bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cretaceous magnetostratigraphy of the southern Simao Basin, SE Tibetan Plateau, and its paleogeographic implications
Authors: Zhang Dawen , Yan Maodu , Fang Xiaomin , Zhang Weilin , Shen Miaomiao , Song Chunhui 
Published: August 2024

Abstract
Precise stratigraphic chronology is the basis of many studies (e.g., tectonic, paleoclimate, and mineralization) in geoscience. Here, we carried out a detailed youngest detrital zircon U-Pb age-constrained magnetostratigraphic study on the middle-lower parts of a 2309-m-thick Upper Jurassic–Lower Cretaceous sequence from west Jiangcheng in the southern Simao Basin, southeastern Tibetan Plateau. A total of 2262 paleomagnetic samples were collected for magnetostratigraphy, and five siltstone/sandstone samples were collected for detrital zircon U-Pb analyses. Progressive thermal and alternating field demagnetizations isolated 1575 well-defined interpreted primary characteristic remanent magnetization directions, which yielded 25 normal polarity (N7–N31) and 25 reverse polarity (R8–R32) magnetozones. The interpreted maximum depositional ages calculated using the youngest detrital zircon U-Pb dates are 159.0 Ma, 154.0 Ma, 161.0 Ma, 149.3 Ma, and 139.5 Ma for the stratigraphic horizons at 2303 m, 1986 m, 1600 m, 1350 m, and 1110 m, respectively, in the section. Together with the previous magnetostratigraphic results of the upper part of the section, the observed polarity zones are best correlated with chrons C34n–M17r of the geomagnetic polarity timescale (GPTS2012), yielding magnetostratigraphic age estimates of ca. 143.5 Ma to ca. 65.0 Ma for the entire stratigraphic sequence. Paleogeographic analysis shows that the Simao Basin was in a low-latitude offshore environment during the Late Jurassic–earliest Cretaceous (before 142.3 Ma), a dominant fluvial environment during the early–middle Early Cretaceous (142.3–111.5 Ma), with widespread desertification at the end of this period, a saline lake sedimentary environment during the late Early Cretaceous–early Late Cretaceous (111.5–88.7 Ma), and a fluvial environment during the late Late Cretaceous (88.7–65.0 Ma). The changes in depositional environment are consistent with regional/global tectonic and paleoclimate changes, such as the dismission of Pangea, the termination of the megamonsoon, and the closure of the Meso-Tethys Ocean.
Reported community engagement in health equity research published in high-impact medical journals: a scoping review
Authors: Medeiros Priscilla , Shetty Janavi , Lamaj Luiza , Cunningham Jessie , Wanigaratne Susitha , Guttmann Astrid , Cohen Eyal 
Published: August 2024

ObjectiveTo assess reported community engagement in the design and conduct of health equity-focused articles published in high-impact journals.DesignScoping review follows guidance from the Joanna Briggs Institute and Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist.Data sourcesWe selected the three highest-ranked journals from the ‘Medicine—General and Internal’ category including the Journal of the American Medical Association (JAMA), The Lancet and The New England Journal of Medicine (NEJM) along with all journals under their family of subspecialty journals (JAMA Network, The Lancet Group and the NEJM Group). Ovid MEDLINE was searched between 1 January 2021 to 22 September 2022.Eligibility criteriaWe included health equity-focused articles and assessed for the reporting of community engagement at each stage of the research process.Data extraction and synthesisTwo independent reviewers extracted data from articles that met the inclusionary criteria. Inter-rater reliability was assessed using Cohen’s kappa to measure the agreement between two independent reviewers. Disagreements were adjudicated by a third independent reviewer.Results7616 articles were screened, 626 (8.2%) met our inclusion criteria: 457 (3.8%) were published by the JAMA Network; 167 (2.4%) by The Lancet Group; and 2 (0.2%) by the NEJM group. Most articles were from USA (68.4%) and focused on adult populations (57.7%). The majority of the articles focused on the topic of race/ethnicity (n=176, 28.1%), socioeconomic status (n=114, 18.2%) or multiple equity topics (n=111, 17.7%). The use of community engagement approaches was reported in 97 (15.5%) articles, of which 13 articles (13.4%) reported engagement at all stages. The most common form of reported engagement was in the acknowledgement or additional contribution section (n=86, 88.7%).ConclusionsCommunity engagement is infrequently reported in health equity-focused research published in high-impact medical journals.
External validation of serum biomarkers predicting short-term and mid/long-term relapse in patients with Crohn’s disease stopping infliximab
Authors: Pierre Nicolas , Huynh-Thu Vân Anh , Baiwir Dominique , Mazzucchelli Gabriel , Fléron Maximilien , Trzpiot Lisette , Eppe Gauthier , De Pauw Edwin , Laharie David , Satsangi Jack , Bossuyt Peter , Vuitton Lucine , Vieujean Sophie , Colombel Jean-Frédéric , Meuwis Marie-Alice , Louis Edouard 
Published: August 2024

ObjectiveIn patients with Crohn’s disease (CD) on combination therapy (infliximab and immunosuppressant) and stopping infliximab (cohort from the study of infliximab diSconTinuation in CrOhn’s disease patients in stable Remission on combined therapy with Immunosuppressors (STORI)), the risk of short-term (≤6 months) and mid/long-term relapse (>6 months) was associated with distinct blood protein profiles. Our aim was to test the external validity of this finding in the SPARE cohort (A proSpective Randomized Controlled Trial comParing infliximAb-antimetabolites Combination Therapy to Anti-metabolites monotheRapy and Infliximab monothErapy in Crohn's Disease Patients in Sustained Steroid-free Remission on Combination Therapy).DesignIn SPARE, patients with CD in sustained steroid-free clinical remission and on combination therapy were randomly allocated to three arms: continuing combination therapy, stopping infliximab or stopping immunosuppressant. In the baseline serum of the STORI and SPARE (arm stopping infliximab) cohorts, we studied 202 immune-related proteins. The proteins associated with time to relapse (univariable Cox model) were compared between STORI and SPARE. The discriminative ability of biomarkers (individually and combined in pairs) was evaluated by the c-statistic (concordance analysis) which was compared with C-reactive protein (CRP), faecal calprotectin and a previously validated model (CEASE).ResultsIn STORI and SPARE, distinct blood protein profiles were associated with the risk of short-term (eg, high level: CRP, haptoglobin, interleukin-6, C-type lectin domain family 4 member C) and mid/long-term relapse (eg, low level: Fms-related tyrosine kinase 3 ligand, kallistatin, fibroblast growth factor 2). At external validation, the top 10 biomarker pairs showed a higher c-statistic than the CEASE model, CRP and faecal calprotectin in predicting short-term (0.76–0.80 vs 0.74 vs 0.71 vs 0.69, respectively) and mid/long-term relapse (0.66–0.68 vs 0.61 vs 0.52 vs 0.59, respectively).ConclusionIn patients with CD stopping infliximab, we confirm that the risk of short-term and mid/long-term relapse is associated with distinct blood protein profiles showing the potential to guide infliximab withdrawal.Trial registration numberNCT00571337andNCT02177071.
Dual‐Task Performance in Individuals With Chronic Obstructive Pulmonary Disease: A Systematic Review With Meta‐Analysis
Authors: Pasten Joselyn González , Aguayo Jennifer Campos , Aburto Javiera , Araya-Quintanilla Felipe , Álvarez-Bustos Alejandro , Valenzuela-Fuenzalida Juan José , Camp Pat G. , Sepúlveda-Loyola Walter 
Published: August 2024

Background: Chronic obstructive pulmonary disease (COPD) is characterized by important extrapulmonary alterations that could affect the performance in dual task (DT) (motor and cognitive tasks executed simultaneously), which is defined as DT interference (DTI).Objective: To compare the performance of DT between individuals with COPD and healthy control subjects (HCSs).Methods: The literature search was conducted in seven databases (Medline, Scopus, Web of Science, PEDro, SciELO, LILACS, and Google Scholar) up to December 2023, including studies published in English, Spanish, or Portuguese. Studies with individuals diagnosed with COPD older than 60 years, who were evaluated with any DT assessment, and compared with HCS were included. The quality of the studies was evaluated using the risk of bias in nonrandomized studies of interventions (ROBINS‐I). The meta‐analysis was performed with JAMOVI software 5.4. The study protocol was registered on PROSPERO (CRD42023435212).Results: From a total of 128 articles, 5 observational studies were selected in this review, involving 252 individuals aged between 60 and 80 years, from France, Italy, Canada, Turkey, and Belgium. Notable DTI was observed in individuals with COPD compared to HCS (standard mean difference [SMD] = 0.91; 95% confidence interval (CI) 0.06–1.75, p = 0.04). Individuals with COPD had impaired gait speed, balance control, muscle strength, and cognitive interference during DT compared to HCS. DT assessment protocols included different combination of motor and cognitive tasks, using functional test, gait analysis, and muscle strength paired with countdown and verbal fluency tasks. Studies presented low (n = 2), moderate (n = 1), and serious (n = 2) overall risk of bias.Conclusion: Older adults diagnosed with COPD exhibited a significant DTI compared to HCSs, which is characterized by poorer physical and cognitive performance during DT execution. These findings highlight the importance of incorporating DT assessments into clinical practice for individuals with COPD.
The Complex Regulation of Cytokinesis upon Abscission Checkpoint Activation
Authors: Gibieža Paulius , Petrikaitė Vilma 
Published: August 2024

Abstract
Cytokinetic abscission is a crucial process that guides the separation of daughter cells at the end of each cell division. This process involves the cleavage of the intercellular bridge, which connects the newly formed daughter cells. Over the years, researchers have identified several cellular contributors and intracellular processes that influence the spatial and temporal distribution of the cytoskeleton during cytokinetic abscission. This review presents the most important scientific discoveries that allow activation of the abscission checkpoint, ensuring a smooth and successful separation of a single cell into two cells during cell division. Here, we describe different factors, such as abscission checkpoint, ICB tension, nuclear pore defects, DNA replication stress, chromosomal stability, and midbody proteins, which play a role in the regulation and correct timing of cytokinetic abscission. Furthermore, we explore the downsides associated with the dysregulation of abscission, including its negative impact on cells and the potential to induce tumor formation in humans. Finally, we propose a novel factor for improving cancer therapy and give future perspectives in this research field.
Abstract 2027: Validation of a Bleeding Risk Score for Acute Coronary Syndromes
Authors: Correia Luis C , Rocha Mário S , Teixeira Marcelo , Cerqueira Thais , Vasconcelos Ana , Merelles Saulo , Reis Tiago , Esteves J. Péricles 
Published: August 2024

Background: a number of prospective registries have identified independent predictors of bleeding during hospitalization for acute coronary syndromes (ACS). However, no score is validated to estimate individual risk of bleeding in ACS.

Objectives and Methods: in order to create and validate a score for estimating risk of bleeding at admission of patients with ACS, independent predictors of bleeding reported in the GRACE registry (

Circulation

2007
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) were utilized according to the following rule: the presence of variables with odds ratio (OR) ≥ 2.5 in the GRACE registry added 3 points to the score, OR = 1.5–2.4 added 2 points and those with OR < 1.5 added 1 point. Only information available at admission were considered: previous history of bleeding (3 points), creatinine clearance < 30 ml/min (2 points), clearance = 30 – 60 ml/min (1 point), female gender (2 points), each 10 years of aging after 30 years old (1 point), ST-segment depression (1 point), peripheral artery disease (1 point), smoking (1 point). In order to validate the score, a sample of 383 consecutive individuals (66±12 yo, 58% males) admitted with ACS between 1999 and 2007 was studied. Inclusion criteria were defined as chest discomfort with at least one of the following: ST-segment elevation, ST-segment depression, T wave inversion, positive troponin or previous coronary artery disease. Major bleeding was defined as hematocrit fall ≥ 10%, blood transfusion of at least 2 units, intracerebral bleeding or fatal bleeding.

Results: incidence of major bleeding was 3.1%. The bleeding score statistically predicted major bleeding (C-statistics=0.66; 95%IC = 0.52– 0.80). Patients in the first two quartiles of score distribution (1– 4 points) experienced the lowest risk of bleeding (1.6%), those in the third quartile (6 points) had intermediate risk (2.7%) and individuals in the fourth quartile (7–10 points) had the highest risk observed (6%, P=0.089). When sample population was dichotomized according to the best cut-off point in risk discrimination, those with a score ≥ 7 had 6% risk of bleeding, compared to individuals with a score < 7 (1.9%, P=0.03).
Conclusion: the tested score discriminates bleeding risk and is a potentially useful tool in clinical decision during acute coronary syndromes.
Research Letter: Dispensing of psychotropic medications in Australia between 2013 and 2022
Authors: Almeida Osvaldo P , Etherton-Beer Christopher , Sanfilippo Frank , Preen David B , Page Amy 
Published: August 2024

Objective: The objective of this study was to determine the proportion of Australians dispensed psychotropic medications between 2013 and 2022 according to their age. Methods: Services Australia provided a de-identified 10% random Pharmaceutical Benefits Scheme sample that allowed us to determine, for each year, the proportion of Australians dispensed at least one script for antipsychotics, antidepressants, anxiolytics, or hypnotics. The classification of medications followed Anatomical Therapeutic Chemical coding. Participants were stratified into 10-year age groups from 0–9 to ⩾90 years, and sex was coded as male/female. We retrieved population numbers from the Australian Bureau of Statistics. Results: The number of records per year ranged from 1,540,520 to 1,746,402, and 54.10% were for females. A greater proportion of older adults, particularly those aged ⩾70 years, were dispensed antipsychotics, antidepressants, anxiolytics and hypnotics than any other age group. The proportion of people who dispensed antipsychotics, anxiolytics and hypnotics declined between 2013 and 2022 but increased for antidepressants, most markedly for adolescents and young adults. Females were more frequently dispensed antidepressants, anxiolytics and hypnotics than males, but males were more frequently dispensed antipsychotics than females, albeit not in later life. Conclusion: Older age groups and females are the most frequent recipients of psychotropic medications dispensed in Australia.
Investor Protection Paradigm in India: Mounting Criticality of Digitalisation
Authors: Mohapatra C S , Ghosh Depannita 
Published: August 2024

With the advent of digitalisation and expansion of the retail market in recent years, India has experienced a significant shift in its financial landscape, necessitating an increased emphasis on investor education and protection. This article delves into the intricate relationship between investor education and investor protection, emphasising the pivotal role of the government, regulators and financial institutions in framing protective measures for investors. With the rise of digitalisation, particularly fintech, the financial services sector has witnessed transformative changes, influencing access to investment opportunities. This exploratory article reviews the existing architecture for investor protection and stresses the need for a dynamic and well-coordinated approach, robust complaint resolution mechanism, and comprehensive research to enhance investor protection in this evolving financial ecosystem. It discusses notable initiatives, including the National Strategy on Financial Education and its 5C strategy, suggesting an additional ‘6th C’, that is, a class-oriented approach to serve as a key driver in creating a financially aware and empowered India. The strengthening of the regulatory framework with adequate cybersecurity measures, launch of an online portal for claim settlement and the establishment of a Centralised Grievance Redressal system are highlighted as crucial steps in building a comprehensive investor protection framework. The authors also highlight that investor protection is a two-way approach involving the government and regulatory bodies on the one hand and investors on the other, with both sides being equally accountable, alert and watchful in the digital era. JEL Codes: D02, D14, D18, G18, G21, G22, G23, G28
Physical activity levels in patients with chronic venous insufficiency
Authors: Domingues Wagner Jorge Ribeiro , Germano-Soares Antonio Henrique , Cucato Gabriel Grizzo , de Souza Lenon Corrêa , Brandão Emely Kércia Santiago de Souza , Souza Emmina Lima da Cruz de , da Silva e Silva Thiago Renan , Arêas Guilherme Peixoto Tinoco , Costa Cleinaldo , Campelo Priscilla Ribeiro dos Santos , dos Santos Neivaldo José Nazaré , Silva Gustavo Oliveira da , Simões Caroline Ferraz 
Published: August 2024

Background Increasing the levels of physical activity (PA) is widely recommended for people with chronic venous insufficiency (CVI). However, studies investigating the patterns of PA and adherence to PA guidelines using objective measures are lacking. Objective The primary aim was to examine the patterns of PA and adherence to PA guidelines among patients with CVI. A secondary aim was to identify whether adherence to PA recommendations differed according to patients’ sociodemographic and clinical characteristics. Methods This cross-sectional study included 96 patients with CVI with Clinical-Etiology-Anatomy-Pathology (CEAP) C3 to C6 (69.1% women 59 ± 11 years; 51.5% C5-C6 on CEAP classification). Objective time spent in PA was measured by a triaxial accelerometer. To examine adherence to PA guidelines, patients were grouped as meeting (or) the recommendations if they had at least 150 min/week of moderate to vigorous PA. Sociodemographic and clinic characteristics were obtained by self-report. Binary logistic regression was employed to examine whether sociodemographic and clinical characteristics were associated with adherence to PA guidelines. T-tests were employed to compare PA levels at different intensities according to patients’ age. Results Patients spent an average of 311.4 ± 91.5 min/week, 42.1 ± 28.0 min/week, and 19.8 ± 17.8 min/week in low-light PA, high-light PA, and moderate-to-vigorous PA, respectively. The proportion of patients meeting PA recommendations was 36.2%, and older patients had lower odds (OR = 0.94; 95%CI: 0.89 to 0.99). Additional analysis reinforced that by showing lower time in high-light PA (51.2 ± 30.0 min/day vs. 31.9 ± 21.8 min/day; p = .001) and moderate-to-vigorous PA (24.3 ± 15.8 min/day vs. 14.8 ± 18.8 min/day; p = .012) among older patients than their peers younger. Conclusion Our findings showed that 36,2% of CVI patients met PA recommendations, with lower odds found among older patients. Public health interventions to enhance PA engagement among CVI patients should prioritize those who are older.
Burnout and occupational stress of home care rehabilitation professionals transitioning out of the COVID-19 pandemic in Ontario, Canada
Authors: Nowrouzi-Kia Behdin , King Emily , Edwards Brydne , Nizzer Sonia , Yazdani Amin , Gohar Basem , Bani-Fatemi Ali , Howe Aaron , Fayyaz Yusra , Alam Bushra , Khan Raabia , Chattu Vijay Kumar 
Published: August 2024

Introduction: The COVID-19 pandemic has significantly impacted the home healthcare industry, with increased rates of burnout and stress among homecare rehabilitation professionals (hcRPs). This study aimed to (1) examine the nature of burnout and occupational stress among homecare rehabilitation professionals at a large home care organization in Ontario, Canada, transitioning out of the pandemic, and (2) assess its impact on work participation and engagement. Methods: We conducted a cross-sectional survey using the National Institute for Occupational Safety and Health Generic Job Stress Questionnaire and Copenhagen Burnout Inventory to examine burnout and job stress. Results: One hundred thirty-nine participants identified that work stress and burnout are more likely to occur when one struggles to cope, experiences unexpected circumstances, and feels a lack of control, which can lead to anger and emotional exhaustion. The adjusted odds ratio for emotional exhaustion was 5.46, indicating that the probability of experiencing work stress among homecare rehabilitation professionals increases as emotional exhaustion increases. Significant associations were found between coping with daily tasks and levels of burnout. Conclusion: Work stress and burnout influence coping, unexpected circumstances in homecare rehabilitation professionals work–life. Furthermore, highlighting the need to provide organizational support and policies that specifically address these issues in the home care sector.
Anxiety-like Characteristics, Forepaw Thermal Sensitivity Changes and Glial Alterations 1 Month After Repetitive Blast Traumatic Brain Injury in Male Rats
Authors: Kallakuri Srinivasu , Sadik Nareen , Davidson Cameron J. , Gheidi Ali , Bosse Kelly E. , Bir Cynthia A. , Conti Alana C. , Perrine Shane A. 
Published: August 2024

Background Many military service members are victims of repetitive blast traumatic brain injuries (rbTBI) and endure diverse altered psychological and behavioural conditions during their lifetime. Some of these conditions include anxiety, post-traumatic stress and pain. Thus, this study attempts to fill the knowledge gap on enduring behavioural and neuroinflammatory marker alterations 1 month after rbTBI. Purpose Although previous rbTBI animal studies have shown behavioural and histopathological changes either a few days (acute) or many months (chronic) after trauma, knowledge related to post-traumatic changes during the intermediate timeframe, i.e. a month after rbTBI is less clear or unavailable. Methods Sprague–Dawley rats (male; n = 12) were assigned to either rbTBI or sham conditions. Animals assigned to the rbTBI group were subjected to 1 blast exposure per day for three consecutive days, while animals in the sham group were exposed to identical experimental conditions sans blast exposure. All animals were tested for anxiety at baseline. 30 days post-injury, animals were tested again for anxiety and paw thermal sensitivity, followed by brain harvest for immunohistochemical analyses. Results Animals exposed to rbTBI showed signs of anxiety-like behaviour on parameters of elevated plus-maze and behavioural signs of pain indicated by reduced thermal withdrawal latency of the forepaw. Histologically, brain sections from animals exposed to rbTBI showed a significantly increased number of microglial/macrophage and astrocytic counts in the medial prefrontal cortex. Conclusion Data from this initial preclinical study support the prevalence of putative anxiety-like behaviour, enhancement in forepaw thermal sensitivity and increase in the number of glial cells even 1 month after rbTBI. These findings have potential implications in the treatment evaluation of blast-exposed military and civilian populations and emphasise the need for devising protective measures for people susceptible to single or repeated exposures. A greater further understanding of rbTBI-related chronic concurrent behavioural and neuropathological sequela is warranted.