bluuebunny/crossref_metadata_2025_split huggingface dataset:
A General Copper‐Box System for the Asymmetric Arylative Functionalization of Benzylic, Propargylic or Allenylic Radicals
Authors: Wang Peng‐Zi , Zhang Zhihan , Jiang Min , Chen Jia‐Rong , Xiao Wen‐Jing 
Published: July 2024

AbstractRadical‐involved arylative cross‐coupling reactions have recently emerged as an attractive strategy to access valuable aryl‐substituted motifs. However, there still exist several challenges such as limited scope of radical precursors/acceptors, and lack of general asymmetric catalytic systems, especially regarding the multicomponent variants. Herein, we reported a general copper‐Box system for asymmetric three‐component arylative radical cross‐coupling of vinylarenes and 1,3‐enynes, with oxime carbonates and aryl boronic acids. The reactions proceed under practical conditions in the absence or presence of visible‐light irradiation, affording chiral 1,1‐diarylalkanes, benzylic alkynes and allenes with good enantioselectivities. Mechanistic studies imply that the copper/Box complexes play a dual role in both radical generation and ensuing asymmetric cross‐coupling. In the cases of 1,3‐enynes, visible‐light irradiation could improve the activity of copper/Box complex toward the initial radical generation, enabling better efficiency match between radical formation and cross‐coupling.
Redox‐Triggered Debonding of Mussel‐Inspired Pressure Sensitive Adhesives: Improving Efficiency Through Functional Design
Authors: Neubert Tilmann J. , Walter Keven , Schröter Carolin , Guglielmotti Victoria , Hinrichs Karsten , Reinicke Stefan , Taden Andreas , Balasubramanian Kannan , Börner Hans G. 
Published: July 2024

AbstractDebondable pressure‐sensitive adhesives (PSAs) promise access to recyclability in microelectronics in the transition toward a circular economy. Two PSAs were synthesized from a tetravalent thiol star‐polyester forming thiol‐catechol‐connectivities (TCC) with either the biorelated DiDopa‐bisquinone (BY*Q) or the fossil‐based bisquinone A (BQA). The PSAs enable debonding by oxidation of TCC‐catechols to quinones. The extent of debonding efficiency depends on the interaction modes, which are determined by the chemical structure differences of both TCC‐motifs. BY*Q‐TCC‐PSA debonds with exceptional loss of 99 % of its approx. 2 MPa shear strength in glass‐on‐glass junctions. For BQA‐TCC‐PSA, a debonding efficiency of only approx. 60 % was found, irrespective of its initial shear strength, which could be tuned up to approx. 7 MPa. The efficiency of debonding for BY*Q‐TCC‐PSA after TCC‐oxidation is linked to the loss of synergistic interactions without strongly affecting the bulk glue properties, outperforming the purely catechol‐based BQA‐analogue.
Firm commitments on climate change: Effects of science‐based targets on financial outcomes during the COVID‐19 crisis
Authors: Ben‐Amar Walid , Comyns Breeda , Martinez Isabelle 
Published: July 2024

AbstractCorporate social responsibility (CSR) can offer a protective buffer helping firms avoid the worst economic effects in times of crisis. We extend the extant literature by considering whether firm substantive climate commitments are effective at protecting the firm from financial losses during the COVID‐19 pandemic. We assess firm financial outcomes through (1) crash and post‐crash stock performance and (2) the severity of loss in the COVID‐19 stock market crash period. We identify substantive climate commitments as those carbon emission targets aligned with the Science Based Targets initiative (SBTi), which links firm's carbon targets to commitments made under the Paris Agreement. Using a sample of 336 US‐based companies, our findings show that science‐based targets are positively related to crash‐period returns and negatively related to severity of loss. Among firms with science‐based targets, only those externally verified and approved by the SBTi are influential in buffering financial losses during a crisis.
Towards sustainability in the services industry: Does green top management support stimulate an organization's green operational performance? A moderated mediation model
Authors: Bourini Islam , Khassawneh Osama , Mohammad Tamara 
Published: July 2024

AbstractThis study investigates the impact of green strategic alignment (GSA) and top management green support (TMGS) on green operational performance (GOP) within the UAE's Information and Communication Technology (ICT) sector, focusing on the mediating role of proactive environmental strategy (PES) and the moderating effect of green psychological perception (GPP). Employing a quantitative approach through surveys, data were collected from employees at various ICT companies within the UAE who are directly involved in operations that pertain to environmental strategies. This method ensures a comprehensive understanding from those who engage daily with the company's green policies. Using Partial Least Squares Structural Equation Modeling, the research provides empirical evidence on how strategic orientations and management support contribute to environmental sustainability. The findings reveal that both GSA and TMGS positively influence PES, which in turn enhances GOP. Furthermore, GPP significantly strengthens the relationship between PES and GOP, offering deeper insights into the dynamics of strategic management and sustainability in the services industry. This research is pioneering within the region, introducing empirical data on the synergy between management support and PESs, and it highlights the significant enhancement of operational performance through these combined efforts. This not only supports the theoretical frameworks but also provides actionable insights for firms aiming to enhance their green initiatives.
Dual enrollment and multilingual English learners: From equity gaps toward solutions
Authors: Andrews Owen Silverman , Linares Jessenia McCrary , Encarnación Tema , Butler Audra 
Published: July 2024

AbstractMultilingual English learners (MELs) represent 10.4% of P‐12 students and are the fastest‐growing group of students in the United States. Another quickly growing student population are those dual enrolled (DE) in high schools and community colleges. DE increased 7% annually between 2002 and 2011, and increased by 11.5% from fall 2021 to fall 2022 to 1.4 million. However, MELs are less likely to participate in DE. Furthermore, there is scant research on the causes and impacts of this disparity. This lack of participation presents a problem of equity, systemic/strategic enrollment management, and socio‐economic outcomes of education. The authors review gaps, discuss a recent high school‐community college partnership that welcomes MELs into DE, and make recommendations for research, policy, and practice
From the field to the classroom: Exploring instructors’ motivation and the teacher identity in dual credit career and technical education programs
Authors: Davis Kimberly R. , Chen Yu April , Aviles Diana G. 
Published: July 2024

AbstractCompared to other educators, career and technical education (CTE) instructors often possess significant industry knowledge but limited pedagogical skills. Some may define their jobs as role models or trainers for the next generation of professionals, rather than teachers. In this case study, we interviewed 12 CTE dual credit instructors at a CTE center offering CTE dual credit programs to all eligible high school students within an urban public school district located in the southeastern United States. Specifically, this study explored CTE instructors’ educational and professional trajectories, motivations to teach, and identification as teachers. We sought to understand how previous work experiences and other social contexts influenced the teacher identity of CTE dual credit instructors at The Center. Findings about teacher preparation and teacher identity can generate practical recommendations for recruiting and retaining highly competent instructors for CTE dual credit programs.
Benzofuran and Benzo[b]thiophene‐2‐Carboxamide Derivatives as Modulators of Amyloid Beta (Aβ42) Aggregation
Authors: Zhao Yusheng , Singh Kartar , Chowdary Karuturi Rahul , Hefny Ahmed A. , Shakeri Arash , Beazely Mike A. , Rao Praveen P. N. 
Published: July 2024

AbstractA group of N‐phenylbenzofuran‐2‐carboxamide and N‐phenylbenzo[b]thiophene‐2‐carboxamide derivatives were designed and synthesized as a novel class of Aβ42 aggregation modulators. In the thioflavin‐T based fluorescence aggregation kinetics study, compounds 4 a, 4 b, 5 a and 5 b possessing a methoxyphenol pharmacophore were able to demonstrate concentration dependent inhibition of Aβ42 aggregation with maximum inhibition of 54 % observed for compound 4 b. In contrast, incorporation of a 4‐methoxyphenyl ring in compounds 4 d and 5 d led to a significant increase in Aβ42 fibrillogenesis demonstrating their ability to accelerate Aβ42 aggregation. Compound 4 d exhibited 2.7‐fold increase in Aβ42 fibrillogenesis when tested at the maximum concentration of 25 μM. These results were further confirmed by electron microscopy studies which demonstrates the ability of compounds 4 a, 4 b, 4 d, 5 a, 5 b and 5 d to modulate Aβ42 fibrillogenesis. Compounds 5 a and 5 b provided significant neuroprotection to mouse hippocampal neuronal HT22 cells against Aβ42‐induced cytotoxicity. Molecular docking studies suggest that the orientation of the bicyclic aromatic rings (either benzofuran or benzo[b]thiophene) plays a major role in moderating their ability to either inhibit or accelerate Aβ42 aggregation. Our findings support the application of these novel derivatives as pharmacological tools to study the mechanisms of Aβ42 aggregation.
Classification and Summary of Photocatalytic Chemical Reactions Driven by Triplet‐Triplet Annihilation Upconversion
Authors: Yao Wen , Song Xiaojuan , Xue Lin , Liu Shanshan , Tang Linglong , Chen Yanli , Liu Heyuan , Li Xiyou 
Published: July 2024

AbstractTriplet‐triplet annihilation upconversion (TTA‐UC) technology could convert low‐energy light into high‐energy light, and it is a very promising one of the upconversion technologies due to its non‐coherent excitation light, low required excitation optical power density and sensitizer/annihilator flexible adjustability. The application of TTA‐UC into photocatalysis could not only broaden the range of solar energy spectrum utilization, but also bring mild reaction conditions and higher product yields via avoiding the side reaction. However, the detailed catalytic mechanism of TTA‐UC is unclear. Therefore, in this review, we summarized and classified TTA‐UC photocatalytic chemical reactions in terms of mechanism.
An incoherent state‐identity approach to African regional disorder
Authors: Alexandre G. Teixeira Victor 
Published: July 2024

AbstractIn contrast to the conventional literature, which suggests that African disorder underlies religious factors, strategic resources, and ethnic conflicts, this paper offers an analytical account of structural patterns in “State identity.” A new concept model of state identity is proposed through a designed framework for the identity‐building process and is justified by social theories and psychoanalysis. This study argues that historical and traumatic social parameters formed an incoherent state identity due to an interruption in the group‐nation state evolutionary process. No existing study articulates the construction of a self‐identity within the state's integrative process, its development (or interruption thereof) in a sub‐categorical identity, and its causal relation to conflicts; hence, the current study fills that gap.
Stroke in sickle cell patients, epidemiology, pathophysiology, systemic and surgical treatment options and prevention strategies
Authors: Shah Siddharth , Alberts Amelia H. , Ngo Tran B. , Lucke‐Wold Brandon 
Published: July 2024

AbstractBackgroundA hereditary haemoglobinopathy known as sickle cell disease (SCD) affects over 100 000 people in the United States severely. Cerebrovascular disease is a prominent consequence of SCD. By the age of 30, 53% of patients have silent cerebral infarcts (SCIs) (a stroke that occurs without any obvious symptoms because it damages a small part of the brain that isn't responsible for any essential functions), and by the age of 40, 3.8% have overt strokes.Main bodyThe multidimensional burden of cerebrovascular illness in SCD is reviewed in detail in this article, which includes both clinical strokes and the frequently asymptomatic SCIs. The intricate pathophysiology of SCD and stroke is explored. With SCD, there are currently very few methods for preventing primary and secondary stroke; the most common ones are hydroxyurea and blood transfusion. Nevertheless, not enough research has been done on the possible contributions of anticoagulation and aspirin to strokes linked to SCD. Promising evidence is also highlighted in the study, suggesting that new drugs intended to treat SCD may be able to alleviate leg ulcers and renal impairment in addition to reducing unusually high transcranial Doppler flow velocity – a crucial component of cerebrovascular events. Given that these novel medications specifically target haemolysis and vaso‐occlusion, the two main causes of strokes in this population, more research is desperately needed to determine whether they are effective in avoiding strokes in people with SCD. The literature review also emphasizes how common healthcare inequities are and how they hinder advancements in SCD research and management in the United States.ConclusionTo successfully address these inequities, the evaluation recommends more funding for both SCD management and research, as well as for patient and clinician education. This multimodal viewpoint highlights the intricate terrain of cerebrovascular problems associated with SCD and the urgent need for all‐encompassing and fair strategies to improve patient outcomes and advance research.
Temporomandibular disorder pain is associated with increased sick leave and reduced health related quality of life
Authors: Vallin S. , Liv P. , Häggman‐Henrikson B. , Visscher C. M. , Lobbezoo F. , Lövgren A. 
Published: July 2024

AbstractBackgroundTemporomandibular disorders (TMD) are the most common reason for chronic pain in the orofacial area and significantly impact the lives of those affected. The role of lifestyle factors in TMD, however, remains less explored. This cohort study aims to estimate TMD prevalence by addressing potential selection biases and to evaluate the association between TMD and lifestyle factors with a specific focus on sick leave and health related quality of life.MethodsBy linking data on TMD in the general population in Västerbotten, northern Sweden (n = 180,000) to health survey data (n = 120,000), information on sociodemographic factors and quality of life was available for 52,961 individuals (50.6% women) with a mean age of 53 years. We applied inverse probability weighting to adjust for selection bias and Poisson regression to explore associations with TMD.ResultsTMD prevalence was 9.2% during the study period, being higher in women (12.9%) than men (5.4%). Weighting for varying visiting frequencies did not affect TMD prevalence (average difference 0.4% points). Individuals with TMD, especially women, reported more sick leave and use of pain medication, with a significant association between TMD and increased sick leave (prevalence ratio 1.89, 95% CI: 1.78–2.01) among both women and men. In addition, TMD was associated with a lower health related quality of life (p < 0.001).ConclusionThe association of TMD with sick leave highlights the condition's profound impact on the lives of affected individuals. These findings underscore the influence of TMD on work life and the burden of TMD on the societal level.Significance StatementThe findings provide insight into how TMD affect individuals, by incorporating lifestyle factors, social determinants and the impact of sick leave at a population level. By incorporating these areas into the study of TMD, we can deepen our understanding of how TMD affects individuals' lives. This approach may also create opportunities to develop more comprehensive strategies to address TMD, focusing on broader implications beyond the clinical symptoms.
The Achilles’ heel of the truth bias? High personal stakes reduce vulnerability to false information
Authors: Pantazi Myrto , Klein Olivier , Kissine Mikhail 
Published: July 2024

AbstractWhile, by default, people tend to believe communicated content, it is also possible that they become more vigilant when personal stakes increase. A lab (N = 72) and an online (N = 284) experiment show that people make judgements affected by explicitly tagged false information and that they misremember such information as true – a phenomenon dubbed the ‘truth bias’. However, both experiments show that this bias is significantly reduced when personal stakes – instantiated here as a financial incentive – become high. Experiment 2 also shows that personal stakes mitigate the truth bias when they are high at the moment of false information processing, but they cannot reduce belief in false information a posteriori, that is once participants have already processed false information. Experiment 2 also suggests that high stakes reduce belief in false information whether participants’ focus is directed towards making accurate judgements or correctly remembering information truthfulness. We discuss the implications of our findings for models of information validation and interventions against real‐world misinformation.
Prognostic significance of hemorrhage requiring embolization in the setting of previously treated head and neck squamous cell carcinoma: Systematic review and retrospective cohort
Authors: Karadaghy Omar A. , Peterson Andrew M. , Sawaf Tuleen , Renslo Bryan , Miller Brevin , Virgen Celina , Sykes Kevin J. , Doering Michelle M. , Moran Christopher J. , Ullman Henrik , Peterson Jeremy , Pipkorn Patrik , Bur Andrés M. 
Published: July 2024

AbstractBackgroundThe management of acute hemorrhage in patients with previously treated head and neck squamous cell carcinoma (HNSCC) is challenging due to the lack of substantial evidence to guide clinical decision making.MethodsA systematic review and retrospective chart review were performed to identify patients with a history of HNSCC who underwent either primary or adjuvant radiation therapy (RT) and presented with hemorrhagic complications requiring embolization. Patient characteristics, history, presentation, and outcomes were reviewed.ResultsThe systematic review included a total of 182 patients. Heterogeneity existed in outcomes reporting; 1‐year overall survival approached 50%. From the retrospective chart review, 51 patients were included. Median survival time following hemorrhage was 2.2 months (range 1.2–11.4 months). Patients with malignancy at time of hemorrhage were identified as having worse survival.ConclusionsAcute hemorrhage in patients with a history of previously radiated HNSCC portends a high risk of mortality, with patients with active malignancy representing a worse prognostic group.
Recurrence after primary salivary gland carcinoma: Frequency, survival, and risk factors
Authors: Nachtsheim Lisa , Jansen L. , Shabli S. , Arolt C. , Quaas A. , Klussmann J. P. , Mayer M. , Wolber P. 
Published: July 2024

AbstractBackgroundPrimary salivary gland carcinomas (SGC) are rare neoplasms that present therapeutic challenges especially in recurrent tumors. The aim of this study was to investigate the incidence and distribution of tumor recurrence, associated risk factors, and survival.MethodsThis analysis includes data from 318 patients treated for SGC between 1992 and 2020. Survival analysis was performed using the Kaplan–Meier method. Univariate and multivariate analyses were used to identify risk factors associated with recurrence.Results21.7% of the patients developed recurrent disease after a mean of 38.2 months. In multivariate analysis, positive‐resection margins, vascular invasion, and tumor localization in the submandibular gland and small salivary glands were independent factors for recurrence. The 5‐year overall survival was 67%, the 5‐year disease‐free survival was 54%.ConclusionTumor recurrence in SGC occurred in one out of five patients. In highly aggressive entities and patients with risk factors, treatment intensification should be considered.
Deciphering the impact of STAT3 activation mediated by PTPRT promoter hypermethylation as biomarker of response to paclitaxel‐plus‐cetuximab in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
Authors: Cirauqui Beatriz Cirauqui , Peguera Adrià Bernat , Pi‐Sunyer Ariadna Quer , Ferrando‐Díez Angelica , Serrano Jose Luis Ramírez , Viñolas Marta Domenech , García Iris Teruel , García Vanesa Quiroga , Oukadour Imane Chaib , Valencia Andrea González , Vergara Pilar Hernández , de Aguirre Egaña Itziar , Herrero Cristina Queralt , Carbonell Oscar Mesía , Paradís Assumpció López , Esteve Anna , Vila Mireia Margelí , Rosell Rafael , Martínez‐Cardús Anna , Mesía Ricard 
Published: July 2024

AbstractBackgroundSquamous cell carcinoma of the head and neck (SCCHN) is an aggressive disease with poor prognosis. It is known that the activation of STAT3 signaling pathways promotes the development and progression of this neoplasia and it has been described the role of PTPRT as a negative regulator of STAT3. Then, we have evaluated the impact of them as biomarkers of outcome in a series of patients with recurrent and/or metastatic SCCHN treated with weekly paclitaxel‐plus‐cetuximab (ERBITAX) regimen.Patients and methodsBetween 2008 and 2017, 52 patients with recurrent/metastatic SCCHN were treated with ERBITAX at our center, 34 of whom had available tumor samples. Phosphorylated STAT3 (pSTAT3) protein expression was analyzed by immunohistochemistry, STAT3 mRNA expression by qPCR, and PTPRT promoter methylation by methylation‐specific PCR. Molecular results were correlated with response rate (RR), progression‐free survival (PFS), and overall survival (OS).ResultspSTAT3 overexpression was detected in 67% and PTPRT promoter hypermethylation in 41% of tumor samples. PTPRT promoter hypermethylation showed a trend towards an association with lower RR (21% vs. 60%; p = 0.06). A lower RR was also observed in patients with pSTAT3 overexpression (36% vs. 54%) and in those with high STAT3 mRNA levels (43% vs. 64%), but these differences did not reach statistical significance. PTPRT promoter hypermethylation correlated with pSTAT3 overexpression (p = 0.009) but not with STAT3 mRNA overexpression. OS and PFS was shorter in patients with activated STAT3, but the difference did not reach statistical significance.ConclusionsAlthough this was a relatively small retrospective study, it provides preliminary indications of the potential role of the STAT3 pathway on outcome in SCCHN and confirms that PTPRT acts as a negative regulator of STAT3. Our findings warrant investigation in a larger patient cohort to determine if inactivating this pathway through specific targeted treatments could improve outcomes in recurrent/metastatic SCCHN patients.