bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attitudes and gaps in knowledge of the diagnosis, treatment, and psychopathology of eating disorders among different health professionals
Authors: Monteleone Alessio Maria , Carfagno Marco , Barone Eugenia , Cascino Giammarco , Pitocco Armando , Brandi Carlotta , Landolfi Lorenzo , Toni Claudia , Sampogna Gaia , Fiorillo Andrea 
Published: June 2024

Abstract
Background
Health professionals from different specialties in medical and psychological areas play an important role in diagnosis and treatment of eating disorders (EDs). This study aimed to identify gaps in knowledge about the diagnosis, etiology, and management of EDs and to assess health professionals’ attitudes towards these illnesses.

Methods
A new questionnaire was developed and validated. Residents and consultants working in disciplines involved in the management of EDs (namely, internal medicine, general practitioners, psychiatric area, psychological area, and surgical area) completed the questionnaire. Knowledge and attitudes were compared among the study groups through one-way ANCOVA and chi-square tests.

Results
The final version of the questionnaire consisted of 54 items assessing the following areas: stigma, treatment, physical complications, diagnosis, and aetiopathogenesis of EDs. For all health professionals the area of most deficiency was the aetiopathogenesis, while the best one was the management of physical complications. All medical professionals showed less knowledge than psychiatrists in terms of etiology, diagnosis, and treatment of EDs. A lack of knowledge about evidence-based psychotherapies, general psychopathology, and family members’ role in the management of EDs emerged among all health professionals. Stigma was found among non-mental health professionals who considered these patients to be different from others and responsible for their abnormal eating behaviors.

Conclusions
Clarifying the health professionals’ specific gaps occurring in the knowledge of EDs and in the attitudes towards these individuals may inform educational programs to improve early detection and management of EDs.
Community buprenorphine continuation post-release following extended release vs. sublingual buprenorphine during incarceration: a pilot project in Maine
Authors: O’Connor Alane B. , Gelsinger Catherine , Donovan Sadie M. , Marshall Jessica , Ahrens Katherine A. 
Published: June 2024

Abstract
Background
The aim of our study was to evaluate the post-release outcomes of incarcerated individuals with opioid use disorder (OUD) treated with extended-release buprenorphine (XRB) in a rural county jail. Administrative data were collected from a pilot program within a jail in Maine that introduced XRB treatment in 2022 and a comparable jail utilizing sublingual buprenorphine (SLB) during the same period to compare post-release outcomes. Log-binomial regression models were used to estimate the risk ratio (RR) and 95% confidence interval (CI) for jail use of XRB vs. SLB on post-release community buprenorphine continuation.

Results
From September 2022 to September 2023, 70 individuals who received XRB were released from the pilot jail and 130 individuals who received SLB were released from the comparison jail. After adjusting for age, sex, and buprenorphine use at entry to jail, individuals released from the pilot jail were almost 3 times (adjusted RR = 2.67, 95% CI 1.84, 3.88) as likely to continue community buprenorphine treatment post-release relative to the comparison jail. In addition, utilization of XRB allowed for expanded access to OUD treatment, was well tolerated, and reduced medication diversion.

Conclusions
In this pilot program in Maine, XRB treatment during incarceration was associated with higher post-release community buprenorphine continuation when compared to individuals treated with SLB. These findings provide strong evidence for the superiority of XRB vs. SLB for the treatment of OUD in jail settings.
Discovery of Loureirin analogues with colorectal cancer suppressive activity via regulating cell cycle and Fas death receptor
Authors: Li Peng , Tian Xiangjuan , Zhang Die , Ou Huiping , Huang Qiufeng , Jin Wenbin , Liu Ran 
Published: June 2024

AbstractChalcones and dihydrochalcones (DHCs) are important bioactive natural products (BNPs) isolated from traditional Chinese medicine. In this study, 13 chalcones were designed with the inspiration of Loureirin, a DHC extracted from Resina Draconis, and synthesized by classical Claisen-Schmidt reactions. Afterwards the reduction reactions were carried out to obtain the corresponding DHCs. Cytotoxicity assay indicated chalcones and DHCs possessed selective cytotoxicity against colorectal cancer (CRC) cells. The preliminary structure-activity relationships (SAR) of these compounds suggested the α, β-unsaturated ketone of the chalcones were crucial for the anticancer activity. Interestingly, compounds 3d and 4c exhibited selective anticancer activity against CRC cell line HCT116 with IC50s of 8.4 and 17.9 μM but not normal cell. Moreover, 4c could also inhibit the migration and invasion of CRC cells. Mechanism investigations showed 4c could induce cell cycle G2/M arrest by regulating cell cycle-associated proteins and could also up-regulate Fas cell surface death receptor. The virtual docking further pointed out that compounds 3d and 4c could nicely bind to the Fas/FADD death domain complex (ID: 3EZQ). Furthermore, silencing of Fas significantly enhanced the proliferation of CRC cells and attenuated the cytotoxicity induced by 4c. These results suggested 4c exerted its anticancer activity possibly regulating cell cycle and Fas death receptor. In summary, this study investigated the anticancer activity and mechanism of Loureirin analogues in CRC, suggesting these compounds may warrant further investigation as promising anticancer drug candidates for the treatment of CRC.
Neuropeptide FF (NPFF)-positive nerve cells of the human cerebral cortex and white matter in controls, selected neurodegenerative diseases, and schizophrenia
Authors: Wiesner Diana , Feldengut Simone , Woelfle Sarah , Boeckers Tobias M. , Ludolph Albert C. , Roselli Francesco , Del Tredici Kelly 
Published: June 2024

AbstractWe quantified and determined for the first time the distribution pattern of the neuropeptide NPFF in the human cerebral cortex and subjacent white matter. To do so, we studied n = 9 cases without neurological disorders and n = 22 cases with neurodegenerative diseases, including sporadic amyotrophic lateral sclerosis (ALS, n = 8), Alzheimer’s disease (AD, n = 8), Pick’s disease (PiD, n = 3), and schizophrenia (n = 3). NPFF-immunopositive cells were located chiefly, but not exclusively, in the superficial white matter and constituted there a subpopulation of white matter interstitial cells (WMIC): Pyramidal-like and multipolar somata predominated in the gyral crowns, whereas bipolar and ovoid somata predominated in the cortex surrounding the sulci. Their sparsely ramified axons were unmyelinated and exhibited NPFF-positive bead-like varicosities. We found significantly fewer NPFF-immunopositive cells in the gray matter of the frontal, cingulate, and superior temporal gyri of both sporadic ALS and late-stage AD patients than in controls, and significantly fewer NPFF-positive cells in the subjacent as well as deep white matter of the frontal gyrus of these patients compared to controls. Notably, the number of NPFF-positive cells was also significantly lower in the hippocampal formation in AD compared to controls. In PiD, NPFF-positive cells were present in significantly lower numbers in the gray and white matter of the cingulate and frontal gyrii in comparison to controls. In schizophrenic patients, lower wNPFF cell counts in the neocortex were significant and global (cingulate, frontal, superior temporal gyrus, medial, and inferior gyri). The precise functions of NPFF-positive cells and their relationship to the superficial corticocortical white matter U-fibers are currently unknown. Here, NPFF immunohistochemistry and expression characterize a previously unrecognized population of cells in the human brain, thereby providing a new entry-point for investigating their physiological and pathophysiological roles.
Advancing architectural heritage: precision decoding of East Asian timber structures from Tang dynasty to traditional Japan
Authors: Gao Chan , Zhao Genfeng , Gao Sen , Du Shuxin , Kim Eunyoung , Shen Tao 
Published: June 2024

Abstract
The convergence of cultural and aesthetic elements in timber structures from China’s Tang Dynasty (618–907 AD) and traditional Japanese architecture provides a rich tapestry of architectural evolution and cross-cultural exchanges. Addressing the challenge of distinguishing and understanding the intricate styles of these structures is significant for both historical comprehension and preservation efforts. This research introduces an innovative approach by integrating the Multi-Head Attention (MHA) mechanism into the YOLOv8 model, enhancing the detection of architectural features with improved precision and recall. Our novel YOLOv8-MHA model not only demonstrates a notable improvement in recognizing intricate architectural details but also significantly advances the state of the art in object detection within complex settings. Quantitative results underscore the model’s effectiveness, achieving a precision of 95.6%, a recall of 85.6%, and a mean Average Precision (mAP@50) of 94% across various Intersection over Union (IoU) thresholds. These metrics highlight the model’s superior capability to accurately identify and classify architectural elements, especially within environments rich with nuanced details, utilizing the enhanced YOLOv8-MHA algorithm. The application of our model extends beyond mere architectural analysis; it offers new insights into the intricate interplay of cultural identity and adaptability inherent in East Asian architectural heritage. The study establishes a solid foundation for the meticulous classification and analysis of architectural styles in timber structures within an expansive cultural and historical context, thereby enriching our understanding and preservation of these traditions.
ArchGPT: harnessing large language models for supporting renovation and conservation of traditional architectural heritage
Authors: Zhang Jiaxin , Xiang Rikui , Kuang Zheyuan , Wang Bowen , Li Yunqin 
Published: June 2024

Abstract
The renovation of traditional architecture contributes to the inheritance of cultural heritage and promotes the development of social civilization. However, executing renovation plans that simultaneously align with the demands of residents, heritage conservation personnel, and architectural experts poses a significant challenge. In this paper, we introduce an Artificial Intelligence (AI) agent, Architectural GPT (ArchGPT), designed for comprehensively and accurately understanding needs and tackling architectural renovation tasks, accelerating and assisting the renovation process. To address users’ requirements, ArchGPT utilizes the reasoning capabilities of large language models (LLMs) for task planning. Operating under the use of tools, task-specific models, and professional architectural guidelines, it resolves issues within the architectural domain through sensible planning, combination, and invocation. Ultimately, ArchGPT achieves satisfactory results in terms of response and overall satisfaction rates for customized tasks related to the conservation and restoration of traditional architecture.
Study and characterization of paper bookbindings from 16 to 18th stored in the Marciana National Library (Venice)
Authors: Paro Elisa , Benvestito Claudia , Pugliese Silvia , Izzo Francesca Caterina , Balliana Eleonora , Zendri Elisabetta 
Published: June 2024

Abstract
Paper bookbindings have been disregarded for centuries by scholars since they were only considered temporary covering materials for manuscripts and books. Recently, there is a willingness to reconsider these bindings and to evaluate their role. Thanks to the collaboration with the Marciana National Library in Venice, which stores an impressive collection of 849 detached bindings, the current research provides a chemical-physical elucidation about the composition and the manufacture of paper bookbindings realized between the 16th and the eighteenth century in the Venetian area. A selection of bookbindings was analysed by the means of complementary methods (thickness measurements, Attenuated Total Reflection—Fourier-Transform Infrared Spectroscopy (ATR-FTIR), Pyrolysis–Gas Chromatography–Mass Spectrometry (Py-GC–MS) and X-Ray Fluorescence (XRF)). Data evidence the presence of cellulose as the main component of paper pulp; hemicellulose and lignin were identified too, probably related to the presence of linen/hemp rags in the paper production. Gelatine was detected muck likely related to paper sizing; among inorganic additives CaCO3 was found in all samples. The presence of waxy material may be due to past undocumented conservation treatments.
Numerical simulation and safety assessment of fires in historic timber structures based on fire load investigation
Authors: Yi Xiaolie , Lu Shizhu , Zhong Yumeng , Zhang Jifa , Guo Yuqing 
Published: June 2024

Abstract
Historic timber structures face substantial fire loads and complex fire risks. Subsequent renovations and utilization may influence their fire safety performance. Therefore, accurately predicting indoor fire development in historic buildings and assessing their fire safety performance is crucial. Numerical fire simulation is currently at the forefront of analyzing and assessing fire risks in historic buildings. However, there is a shortage of globally accessible historic building fire data. This paper proposes a method to determine fire scenarios, peak heat release rates, and development curves of indoor fires in wooden historic buildings through a fire load investigation. Using the Guangzhou ancestral hall as an example, PyroSim fire dynamics simulation software is employed to calculate fire development and assess the available safe evacuation time. The simulation results are subsequently input into the Pathfinder evacuation simulation software to ascertain the required safe evacuation time for indoor occupants. A comparative assessment is conducted to evaluate the fire safety performance before and after the renovation of historic buildings. The research findings indicate that installing closed glass curtain walls in the courtyards of ancestral hall buildings in Guangzhou accelerates the infiltration of smoke during fires, leading to rapid fire spread and long-distance ignition, significantly reducing the time available for safe evacuation. Therefore, when renovating and utilizing the ancestral hall buildings in Guangzhou, the installation of ventilation and smoke extraction systems should be prioritized to slow down fire development. Additionally, controlling the number of indoor occupants is an effective management measure to mitigate fire damage in historic buildings.
Five worlds of social reproduction after the new millennium: placing transitional China in a three-dimensional model of social reproduction
Authors: Xu Yao 
Published: June 2024

AbstractSince the late 2000s, China has accelerated reconstruction of the welfare state against the backdrop of the second transition. Following a typological approach, this study proposes an analytical framework for assessing varieties of social reproduction before delving into a comparative look at China’s national institutional framework, in which China is regarded as a transitional economy and a late bloomer. As represented in three dimensions, countries have production regimes that diverge in the degree of coordination, welfare regimes that differ in the degree of decommodification, and labor reproduction regimes that vary in the degree of depatriarchalization. We investigate the convergence and divergence of advanced economies, transitional economies, and the emerging economies of East Asian countries. Hierarchical cluster analysis and a three-dimensional map illustrate the varieties of regimes at the intersections of production, welfare, and reproduction. With the help of institutional complementarities, five worlds of social reproduction are distinguished: the late blooming, the liberal, the catch-up/transitional, the conservative, and the social democratic. China’s production regime converges with that of continental Europe and Post-Socialist societies based on institutional arrangements of nonmarket coordination; however, limited income maintenance and redistribution policies, the absence of family-friendly policies, and the regendering of the division of labor make China’s institutional mix appear more compatible with East Asian societies than Western ones. The institutional complementarities between the welfare and labor reproduction regimes reveal a social reproduction scenario that is less than purely late blooming.
Connecting the dots: analysing the relationship between AHI and ODI in obstructive sleep apnea
Authors: Sharma Priya , Thakur Somesh , Rai Deependra Kumar , Karmakar Saurabh , H Ameet 
Published: June 2024

Abstract
Background
In the lab type-1 Polysomnography (PSG) is the gold standard for the diagnosis of Obstructive sleep apnea (OSA). But in view, the increasing prevalence, highly expensive, and the presence of a pandemic state make it sometimes impractical to perform PSG in all patients suspected of OSA. The objective of our study was to compare the correlation between the gold standard Autoscored Apnea Hypopnea Index (AHI) and Oxygen desaturation index (ODI) based classification of the severity of OSA.

Methodology
It was a single-centered hospital-based cross-sectional study in which a total of 176 Subjects suspected of OSA were recruited and underwent overnight 7 channels of in-lab polysomnography at AIIMS Patna. Demographic details, comorbidities, and lab data were collected for all enrolled patients. BMI, STOP-BANG score, and Epworth sleepiness score (ESS) were also calculated for all subjects. They were categorized into mild, moderate, and severe OSA based on AHI and ODI values of 5–14.9, 15–29.9, and ≥ 30 events per hour, respectively.
Recordings of polysomnography (PSG) were presented with descriptive statistics. Data is presented as the “mean ± standard deviations” for continuous variables and percentage frequencies for categorical variables. The Chi-square test was used to compare the discrete variables. Statistical significance was set at an alpha level of 0.05 with P < 0.05, with a two-tailed probability. Spearman's rank correlation analysis was used to test the strength and direction of the association between OSA severity (using AHI classification) and the Oxygen Desaturation Index.

Results
The Mean (SD) age of patients enrolled in our study was 47.42(12.60) years with 57.95% males. Among comorbidities, 31.8% (n = 56) were known cases or incidentally diagnosed with Diabetes Mellitus Type 2, 43.18% (n = 76) were hypertensive and 31.8% (n = 56) had hypothyroidism. The mean HbA1c level among Diabetic patients was 6.05 (1.27) and the mean TSH level among Hypothyroidism patients was 12.24 (27.34). There was a positive correlation between AHI and ODI in our study (Pearson’s correlation coefficient = 0.897).

Conclusion
Good concordance between AHI and ODI makes nocturnal oximetry a less expensive tool to confidently screen patients with severe OSA. This may be applicable in smaller centers where facilities and expertise for a full night PSG may not be easily available.
Stem cell therapies in stroke rehabilitation: a narrative review of current strategies and future prospects
Authors: Aderinto Nicholas , Olatunji Gbolahan , Kokori Emmanuel , Babalola Adetola Emmanuel , Yusuf Ismaila Ajayi , Apampa Oluwatobiloba Oluwatomisin , Ukoaka Bonaventure Michael , Aboje John Ehi , Adefusi Temiloluwa , Moradeyo Abdulrahmon , Obasanjo Opabode Muntaqim , Ogieuhi Ikponmwosa Jude , Omoworare Oluwatobi , Olatunji Doyin 
Published: June 2024

AbstractThis paper explores the potential of stem cell therapies in revolutionising stroke recovery, addressing the limitations of current treatments and emphasising regenerative medicine as a promising alternative. Stroke, a leading cause of disability and death worldwide, necessitates innovative approaches due to the temporal constraints and regenerative deficiencies in existing therapeutic modalities. The review explores the diverse mechanisms underlying stem cell-mediated recovery, encompassing neuroprotection, neurogenesis, angiogenesis, modulation of inflammatory responses, and induction of host brain plasticity. We searched prominent databases (PubMed, Scopus, Google Scholar, and Web of Science) from inception to January 2024 for studies on “stem cell therapy” or “regenerative medicine” combined with “stroke recovery” or “cerebrovascular accident”. Studies in humans and animals, published in peer-reviewed journals, and investigating the impact of stem cell therapy on stroke recovery were included. We excluded non-English publications and those lacking sufficient outcome data. Evidence from animal studies demonstrates the efficacy of various stem cell types, while human studies, though limited, contribute valuable insights into safety and potential efficacy. Safety considerations, crucial for successful clinical application, emphasise the need for rigorous preclinical and clinical studies, long-term follow-up data, and ethical standards. Challenges in the field, such as study design heterogeneity, optimising stem cell delivery methods, and identifying subpopulations likely to benefit, require concerted efforts to overcome. Standardising methodologies, refining delivery routes, and personalising interventions based on biomarkers are essential. This review positions stem cell therapies as promising for comprehensive neural tissue recovery following stroke.
Extent of lymphadenectomy for surgical management of right-sided colon cancer: Multicenter, open label, randomized, controlled trial.
Authors: Xiao Yi , Lu Junyang , Su Xiangqian , Zheng Minhua , Sun Yueming , Du Xiaohui , Chi Pan , Wang Ziqiang , Zhong Ming , WU Aiwen , Zhu Anlong , Li Fei , Xu Jianmin , Kang Liang , Suo Jian , Deng Haijun , Ye Yingjiang , Ding Ke-Feng , Zhang Zhongtao ,   RELARC Study Group
Published: June 2024

3575 Background: Complete mesocolic excision (CME) is being increasingly used for the treatment of right-sided colon cancer although there is still no strong evidence that CME provides better long-term oncological outcomes than D2 dissection. The controversy is mainly regarding the survival benefit from extended lymph node dissection emphasized by CME. Methods: This randomized, controlled, unblinded, phase 3, superiority trial involved 17 hospitals in China. Totally 1,072 patients diagnosed with stage T2-T4aNanyM0 or TanyN+M0 right-sided colon cancer were enrolled from January 11, 2016, through December 26, 2019. Participants were randomly assigned (1:1 ratio) to undergo either CME (n=536) or D2 dissection (n=536) during laparoscopic right colectomy. The primary outcome was the 3-year disease-free survival (DFS), and the main secondary outcome was the 3-year overall survival (OS). Results: Among 1072 patients, 77 were excluded after randomization. The remaining 995 patients (median age 61years, 59% male) were included in the primary analysis (CME [n=495] vs. D2 dissection [n=500]). The 3-year primary outcome assessment was completed for 97% patients. No significant differences were found between the groups in 3-year DFS (86.1% in CME group vs. 81.9% in D2 group; HR = 0.74; 95% confidence interval [CI]: 0.54-1.02; P = 0.06) or in 3-year OS (94.7% in CME group vs. 92.6% in D2 group; HR = 0.70; 95% CI: 0.43-1.16; P = 0.17). Conclusions: For primary surgical excision of right-sided colon cancer, complete mesocolic excision did not improve disease free survival, compared to standard D2 lymph node dissection. Standard D2 dissection should be the routine procedure for these patients. CME should only be considered in patients with obvious mesocolic lymph node involvement. Trial Registration: ClinicalTrials.gov Identifier: NCT02619942. Clinical trial information: NCT02619942 .