bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Delayed Parathyroidectomy on Risk of Future Cardiovascular and Nephrolithiasis Interventions in Adults with Primary Hyperparathyroidism [Original Study]
Authors: Ramonell Kimberly M. , Liou Rachel , Zheng Xinyan , Song Zhixing , Lee James A. , Sedrakyan Art , Chen Herbert 
Published: August 2024

Objective:
To determine whether the timing of parathyroid surgery impacts the risk of renal stone retreatment and cardiovascular interventions.

Summary Background Data:
Long-term, untreated primary hyperparathyroidism is associated with significant morbidity including nephrolithiasis and cardiovascular disease.

Methods:
We conducted a Population-based Cohort study of New York and California state-wide data from 2000-2020. Adult patients who underwent renal stone treatment and subsequently diagnosed with primary hyperparathyroidism (pHPT) and underwent parathyroidectomy (PTX) were included. Patients were excluded if PTX was prior to index stone procedure, they underwent second stone treatment within 6 months, with stage V CKD, with secondary or tertiary hyperparathyroidism, with prior kidney transplant or hemodialysis, or with prior cancer diagnosis. Rate of renal stone retreatment and cardiovascular interventions after PTX in pHPT patients with nephrolithiasis who underwent parathyroid surgery at ≤ 2 years and >2 years after index stone procedure was measured.

Results:
We identified 2,093 patients who underwent first-time stone treatment and subsequent PTX. The median time to PTX was 560 days (IQR 187-1477) and follow-up was 7.4 years (IQR 4.5-13.1). Delaying PTX for more than 2 years increased the risk of renal stone retreatment by 59% (HR 1.59; P<0.001), increased the risk of experiencing coronary disease or associated interventions by 118% (HR=2.18; P=0.01), and increased the risk of experiencing an overall cardiovascular event by 52% (HR 1.52; P<0.01).

Conclusions and Relevance:
In symptomatic pHPT, delaying PTX significantly increases the risk of requiring future stone retreatment and cardiac/vascular surgical interventions. This highlights the importance of early surgical referral and multidisciplinary approaches to optimize outcomes and resource utilization in pHPT.
Promoting sleep and rest in hospitalized children: a best practice implementation project
Authors: Lechosa-Muñiz Carolina , Ruiz-Azcona Laura , Pérez Belmonte Elena , Gallego-Jiménez Marina , Cabero-Pérez María Jesús 
Published: August 2024

ABSTRACTObjective:The objective of this project was to implement scientific evidence to promote sleep and rest in pediatric patients during hospitalization.Introduction:Hospitals are not conducive to quality sleep, as external factors such as light, noise, and interruptions from health care staff can disturb patients. Being hospitalized has a detrimental impact on children's sleep because it reduces how much sleep they get and the quality of that sleep. It has been reported that up to 20% to 30% of hospitalized children experience sleep problems.Methods:This project was conducted at the Marqués de Valdecilla University Hospital in Cantabria, northern Spain. The project used the JBI Evidence Implementation Framework, which is grounded in an audit, feedback, and re-audit process, together with a structured approach to identifying and managing barriers to change. The study subjects were 100 children aged 2 to 16 years, who were admitted to the hospital's pediatric unit from November to December 2021, and 27 multi-disciplinary health care staff.Results:Implementing the evidence-based strategies improved our care practices, with the follow-up audit results showing a marked improvement in compliance. Thus, training health care staff on pediatric sleep increased from 4% to 80%; using a multi-faceted approach to sleep promotion increased from 21% to 87%; and promoting relaxation techniques to promote sleep increased from 0% to 80%.Conclusions:The project met its objectives. Areas for improving children's sleep and rest during hospitalization were identified. To avoid resistance to change, it was necessary to involve the entire team and maintain training. We recommend follow-up audits once a year, to ensure the sustainability of the project.Spanish abstract:http://links.lww.com/IJEBH/A252
ChatGPT as a bioinformatic partner
Authors: Mondillo Gianluca , Perrotta Alessandra , Colosimo Simone , Frattolillo Vittoria 
Published: August 2024

AbstractThe advanced Large Language Model ChatGPT4o, developed by OpenAI, can be used in the field of bioinformatics to analyze and understand cross-reactive allergic reactions. This study explores the use of ChatGPT4o to support research on allergens, particularly in the cross-reactivity syndrome between cat and pork. Using a hypothetical clinical case of a child with a confirmed allergy to Fel d 2 (cat albumin) and Sus s 1 (pork albumin), the model guided data collection, protein sequence analysis, and three-dimensional structure visualization. Through the use of bioinformatics tools like SDAP 2.0 and BepiPRED, the epitope regions of the allergenic proteins were predicted, confirming their accessibility to immunoglobulin E (IgE) and probability of cross-reactivity. The results show that regions with high epitope probability exhibit high surface accessibility and predominantly coil and helical structures. The construction of a phylogenetic tree further supported the evolutionary relationships among the studied allergens. ChatGPT4o has demonstrated its usefulness in guiding non-specialist researchers through complex bioinformatics processes, making advanced science accessible and improving analytical and innovation capabilities.
Epithelial-mesenchymal boundary guides cell shapes and axis elongation in embryonic explants
Authors: Barrett Katia , Anand Shalabh , Thome Virginie , Lenne Pierre-François , Merkel Matthias 
Published: August 2024

AbstractThe spatial arrangement of tissues during development establishes regions of tissue-tissue interactions. While such interactions are prominent during gastrulation and organogenesis, how they guide morphogenesis remains unclear. Here, using Xenopus animal cap explants, we show that the coupling between epithelial and mesenchymal tissues is instrumental in robust axis elongation. We find that mesenchymal and epithelial tissues drive elongation hierarchically - the epithelium can elongate independently, while the mesenchyme requires the initial presence of the epithelium. The epithelial-mesenchymal boundary defines the direction of cell shape alignment and the axis of tissue elongation. Prior to explant elongation, epithelial cells align and elongate, a process that propagates into the underlying mesenchyme. These findings reveal how tissue boundaries can organize coherent axis elongation without external patterning cues, providing insights into the self-organization principles that guide embryonic morphogenesis.
Exact quantization conditions and full transseries structures for
PT
symmetric anharmonic oscillators
Authors: Kamata Syo 
Published: August 2024

We study exact Wentzel–Kramers–Brillouin analysis (EWKB) for a PT symmetric quantum mechanics (QM) defined by the potential VPT(x)=ω2x2+gx2K(ix)ϵ with ω∈R≥0, g∈R>0 and K,ϵ∈N to clarify its perturbative/nonperturbative structure. In our analysis, we mainly consider the massless cases, i.e., ω=0, and derive the exact quantization conditions (QCs) for arbitrary (K,ϵ) including all perturbative/nonperturbative corrections. From the exact QCs, we clarify full transseries structure of the energy spectra with respect to the inverse energy level expansion, and then formulate the Gutzwiller trace formula, the spectral summation form, and the Euclidean path integral. For the massive cases, i.e., ω>0, we show the fact that, by requiring the existence of the solution of the exact QCs, the path of analytic continuation in EWKB is uniquely determined for a given N=2K+ϵ, and in consequence the exact QCs, the energy spectra, and the three formulas are all perturbative. Similarities to Hermitian QMs and resurgence are also discussed as additional remarks.

Published by the American Physical Society
2024
Sodium chloride induced nitrogen salt with cyclo-
N5
anions at high pressure
Authors: Zhang Bi , Xu Meiling , Xin Yu , Lin Shuyi , Hao Jian , Wang Yanchao , Li Yinwei 
Published: August 2024

The energy landscape of sodium chloride-nitrogen mixtures has been comprehensively explored to examine the ability of the formation of unknown compounds under pressures of up to 100 GPa, using swarm-intelligence structure prediction methodology and first-principles calculations. We identified a thermodynamically stable NaN5ClN5 compound containing two cyclo-N5 species under pressures exceeding 53 GPa, representing milder conditions in comparison to those requisite for pure solid nitrogen. In NaN5ClN5, the high electron affinity of the cyclo-N5 motif allows it to oxidize the chlorine atoms, resulting in the formation of two cyclo-N5 anions. Additionally, the weak covalent interactions between Cl and nearby N atoms plays a key role in stabilization of structure. It has been demonstrated that simple NaN5 salt was a suitable precursor for the synthesis of NaN5ClN5 at high pressure. molecular dynamics simulations demonstrated the recoverability of NaN5ClN5 as a metastable phase at ambient pressure-temperature conditions. Additionally, NaN5ClN5 exhibits a higher energy density of 3.86 kJ/g and a lower mass density of 1.67 g/cm3 in comparison to metal pentazolate salts, highlighting its potential as a high energy-density material.

Published by the American Physical Society
2024
Corporate anticorruption disclosure and earnings management: the moderating role of board gender diversity
Authors: Githaiga Peter Nderitu 
Published: August 2024

PurposeCorruption and manipulation of earnings remain a serious concern all over the globe. In addition, corporate disclosure of anticorruption information is still in its infancy in developing and emerging countries. Studies have also highlighted the importance of female directors in corporate disclosures and mitigating earnings management (EM). Therefore, the purpose of this study is to examine the moderating effect of board gender diversity on the relationship between anticorruption disclosure (ACD) on EM among listed firms in the East Africa Community (EAC) partners states.Design/methodology/approachThe study used an ACD check list developed from recent studies and the Global Reporting Initiative (GRI) 205 on anticorruption reporting standards. The sample comprising of 58 firms listed across EAC partner states stock/securities exchanges over the period between 2013 and 2022. The hypotheses were tested using the fixed effect regression model.FindingsThis study found low disclosure of anticorruption practices among the selected firms. The regression results revealed that ACD and board gender diversity negatively affected EM. In addition, the study found that board gender diversity moderated the relationship between ACD and EM. The study used the system generalized method of moment (GMM) model to address endogeneity concerns.Practical implicationsThe study will help policymakers and accounting standards setters in determining if mandatory ACD can reduce harmful EM practices. Furthermore, the findings can be helpful to corporate governance standards setters in deciding whether to implement gender quotas to enhance the effect of ACD on EM.Originality/valueTo the best of the author’s knowledge, this is the first paper that empirically examines the effect of ACD on EM in EAC. The study further adds to the empirical literature by assessing the moderating effect of board gender diversity, which has not been examined by earlier studies on ACD and EM.
Breaking the bias: perspectives of a WiSTEM2D programme inspiring female undergraduates for a technical future
Authors: Travers Marie , Dwivedi Anushree , Richardson Ita , Crowley Katie , Patten James Vincent 
Published: August 2024

PurposeThis is an account of student experiences with the 2020/2021 Johnson & Johnson (J&J) Women in Science, Technology, Engineering, Mathematics, Manufacturing and Design (WiSTEM2D) intervention programme at the University of Limerick (UL).Design/methodology/approachThe WiSTEM2D programme supports female undergraduate students undertaking science, technology, engineering, mathematics, manufacturing and design (STEM2D) courses, helping them develop and grow in their degrees, research and beyond.FindingsDuring the programme, data were gathered from students in the form of qualitative information, which was used to analyse perceptions of the programme. This analysis revealed that students found the WiSTEM2D programme beneficial to them and that it improved their confidence levels, career knowledge and overall networking abilities.Originality/valueWiSTEM2D is one of several initiatives globally that are attempting to empower and encourage women to be active in STEM.
Benefits or costs? Exploring the international expansion process of the business group
Authors: Wang Shan-Huei 
Published: August 2024

PurposeDrawing on the time compression diseconomies perspective and business network theory, this study examines how the international expansion of a business group’s pace, scope and rhythm affects its performance.Design/methodology/approachPanel data (1999–2013) from the top 100 Taiwanese business groups investing in globalization were collected.FindingsThe results show that international pace and rhythm have an inverse U-shaped relationship with business group performance, while the relationship between international scope and business group performance is U-shaped. This study highlights that international expansion is multidimensional and nonlinear and that the factors that shape nonlinear relationships between international processes and performance are different. Furthermore, family group involvement positively moderates the link between international scope and performance and negatively affects the relationship between international pace and performance. However, no significant effect is observed between rhythm and performance. High family business group involvement mitigates the impact of outsiders’ liability and managerial costs; moreover, it enhances the positive effects of location-specific advantages and business network resources.Originality/valueThis study combined the time compression diseconomies perspective and business network theory to explain why and how internationalization may not always lead to good performance by examining the effects of different international expansion processes and the interactive effect of family group involvement.
Examining the extended full-range leadership model and leadership effectiveness in remote work contexts: the moderating role of VUCA environments
Authors: Hüttemann Dominik , Härtel Tobias Marc , Müller Julia 
Published: August 2024

PurposeThe COVID-19 pandemic has amplified the importance of effectively leading a remote workforce in volatile, uncertain, complex and ambiguous (VUCA) environments. This study examines the effectiveness of transformational–transactional leadership (Full-Range Leadership Model, FRLM) and its recent extension of instrumental leadership (eFRLM) in remote work contexts.Design/methodology/approachWe surveyed 529 remote working followers, providing perceptions on (1) their leaders’ manifestation of eFRLM dimensions and factors, (2) their leaders’ leadership effectiveness and (3) their organizational environment as VUCA.FindingsResults show that instrumental leadership represents a strongly effective leadership dimension in remote work contexts, explaining unique variance beyond transformational–transactional leadership. Moreover, VUCA environments moderated the association between eFRLM leadership behaviors and leadership effectiveness, with instrumental leadership being particularly effective in more pronounced VUCA environments and transformational–transactional leadership being less effective.Originality/valueOverall, instrumental leadership appears crucial to consider when predicting leadership effectiveness in virtual and uncertain contexts.
Volunteer tourism in farm communities: interrelationships between capital, empowerment and sustainability
Authors: Nien Tran Tuan , Thuong Ho Tran Thuong 
Published: August 2024

Purpose
Only a small number of studies have analysed the sustainability of the socio-cultural impacts of volunteer tourism (VT). Existing research tends to focus on volunteers, the host communities and organisations, while the interconnectedness between theories (of capitals) and concepts (i.e. empowerment and sustainability) have received minimal attention. Sustainability is considered both an effect of empowerment and a means for achieving it. Drawing on the perspectives and theoretical concepts related to multiple forms of capital, this paper aims to take an interpretive stance to examine socio-cultural impacts.

Design/methodology/approach
This research draws on 37 semi-structured interviews conducted with stakeholders on the perceived socio-cultural impacts of VT on two farm communities in Vietnam. A qualitative thematic coding analysis was used to identify themes that explain the perceptions of the stakeholders within the host communities.

Findings
The findings of this study were divided into the nine themes of educational effects, job opportunities, cultural exchanges, relationships, health, awareness of environmental conservation, physical changes, promoting local products and tourism and community resource development. The research provides additional insights into the interconnectedness between different types of capital, empowerment and sustainability of socio-cultural impacts.

Practical implications
VT organisations should provide more opportunities for local residents to become involved in decision-making regarding volunteer activities and to share their voices and concerns about how the VT programmes are set up. The government could provide support services or training and skills to locals after the volunteers leave, which would be significant in developing and maintaining the sustainability of impacts on host communities.

Originality/value
This research creates a model for connecting capital to sustainability and empowerment to study the socio-cultural impacts of VT.
The Effect of the Federal Judicial System on Public Enforcement: Evidence from SEC Enforcement Actions
Authors: JIA YANRONG 
Published: August 2024

ABSTRACTThis study examines whether the efficiency of federal district courts affects the likelihood of SEC enforcement. The results indicate that the SEC is less likely to initiate enforcement actions against firms in less efficient federal district courts. In addition, the study examines the implications of court efficiency for firms’ financial reporting quality (FRQ). The evidence suggests that firms residing in more efficient federal districts have higher FRQ and the effect is stronger in subsamples with weak private enforcement regimes. Additional analysis of the choice of venue suggests that the SEC's decision to file in the District Court for D.C. is not affected by local court efficiency. Collectively, this study highlights the importance of an efficient federal judicial system for public enforcement.
Principles and challenges of whole cell microbial biosensors in the food industry
Authors: Mendoza América Selene Gaona , Acosta María Fernanda Mendoza , Sánchez Julio Armando Massange , Vázquez Luz Edith Casados 
Published: August 2024

AbstractWhole cell microbial biosensors (WCMB) are mostly genetically modified microorganisms used to detect target molecules as indicators of biological and chemical contaminants as well as in the identification of compounds of interest in the food industry. The specificity and sensitivity of these biosensors are achieved through the design of genetic circuits that make use of genetic sequences such as promoters, terminators, genes encoding regulatory proteins or reporter proteins, among others. Despite the advances of WCMBs for their application, significant challenges are faced, such as cell stability, regulatory restrictions, and the need to optimize response times so that they can be a competitive detection tool in the market. This review explores the technological progress, potential and limitations of WCMBs in the food industry, starting by reviewing the operating principles of biosensors. The importance of selecting appropriate chassis cells and the integration of recognition elements and transducers to maximize their effectiveness in the detection of contaminants and compounds of interest in the food industry is highlighted.
Extension of shelf life of tomato (Solanum lycopersicum L.) by using a coating of polyhydroxybutyrate‐carboxymethyl cellulose‐pectin‐thymol conjugate
Authors: Poosarla Venkata Giridhar , Bisoi Suchitra , Siripurapu Aruna , Rathod Baliram Gurunath , Ramadoss Aparna , Kilaparthi Suresh , Shivshetty Nagaveni , Rajagopalan Gobinath 
Published: August 2024

AbstractThis study targets explicitly finding an alternative to petroleum‐based plastic films that burden the environment, which is a high priority. Hence, polymeric films were prepared with carboxymethyl cellulose (CMC) (4%), pectin (2%), and polyhydroxybutyrate (PHB) (0.5%) with different concentrations of thymol (0.3%, 0.9%, 1.8%, 3%, and 5%) and glycerol as a plasticizer by solution casting technique. The prepared films were tested for mechanical, optical, antimicrobial, and antioxidant properties. Film F5 (CMC + P + PHB + 0.9%thymol) showed an excellent tensile strength of 15 MPa, Young's modulus of 395 MPa, antioxidant activity (AA) (92%), rapid soil biodegradation (21 days), and strong antimicrobial activity against bacterial and fungal cultures such as Klebsiella pneumoniae, Staphylococcus aureus, Escherichia coli, Aspergillus niger, and Aspergillus flavus. The thymol content increase in films F6 (1.8%), F7 (3%), and F8 (5%) displayed a decrease in mechanical properties due to thymol's hydrophobicity. For shelf life studies on tomatoes, F2, a film without thymol (poor antimicrobial and antioxidant activities), F5 (film with superior mechanical, optical, antimicrobial, and antioxidant properties), and F7 (film with low mechanical properties) were selected. Film F5 coatings on tomato fruit enhanced the shelf life of up to 15 days by preventing weight loss, preserving firmness, and delaying changes in biochemical constituents like lycopene, phenols, and AA. Based on the mechanical, optical, antimicrobial, antioxidant, and shelf life results, the film F5 is suitable for active food packaging and preservation.Practical ApplicationThe developed active biodegradable composite can be utilized as a coating to extend the shelf life of fruits and vegetables. These coatings are easy to produce and apply, offering a sustainable solution to reduce food waste. On an industrial scale, they can be applied to food products, ensuring longer freshness without any technical challenges.