bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the optimality of policy choices in the face of biased beliefs, retrospective voting and the down-up problem
Authors: Seixas Carlos , Lourenço Diogo 
Published: June 2024

AbstractPrevious literature has shown that voters’ biased beliefs regarding policy outcomes incentivize the selection of seemingly better, but socially worse, policies. It has also shown that voters’ tendency to gauge an incumbent’s competence by the present state of the economy (retrospective voting) could counteract biased beliefs. In this article, we argue that, when the advantageous consequences of a measure of policy only accrue with considerable lag (the down-up problem), retrospective voting instead amplifies the effects of biased beliefs. Still, we find that it may nevertheless be optimal for an incumbent to select good long-term policies if the incumbent is strongly motivated by the success of the chosen policies. Finally, we investigate the robustness of these conclusions by considering an incumbent bias, limited accountability, and the introduction of incentive and threshold contracts.
Impact of adjuvant chemotherapy on survival after pathological complete response in rectal cancer: a meta-analysis of 31,558 patients
Authors: de Moraes Francisco Cezar Aquino , Kelly Francinny Alves , Souza Maria Eduarda Cavalcanti , Burbano Rommel Mario Rodríguez 
Published: June 2024

Abstract
Background
Locally advanced rectal cancer (LARC) typically involves neoadjuvant chemoradiotherapy (nCRT) followed by surgery (total mesorectal excision, TME). While achieving a complete pathological response (pCR) is a strong indicator of a positive prognosis, the specific benefits of adjuvant chemotherapy after pCR remain unclear. To address this knowledge gap, we conducted a systematic review and meta-analysis to assess the potential advantages of adjuvant therapy in patients who achieve pCR.

Methods
In this study, we searched Medline, Embase, and Web of Science databases for relevant research. We focused on binary outcomes, analyzing them using odds ratios (ORs) with 95% confidence intervals (CIs). To account for potential variability between studies, all endpoints were analyzed with DerSimonian and Laird random-effects models. We assessed heterogeneity using the I2 statistic and employed the R statistical software (version 4.2.3) for all analyses.

Results
Thirty-four studies, comprising 31,558 patients, were included. The outcomes demonstrated a significant difference favoring the AC group in terms of overall survival (OS) (HR 0.75; 95% CI 0.60–0.94; p = 0.015; I2 = 0%), and OS in 5 years (OR 1.65; 95% CI 1.21–2.24; p = 0.001; I2 = 39%). There was no significant difference between the groups for disease-free survival (DFS) (HR 0.94; 95% CI 0.76–1.17; p = 0.61; I2 = 17%), DFS in 5 years (OR 1.19; 95% CI 0.82–1.74; p = 0.36; I2 = 43%), recurrence-free survival (RFS) (HR 1.10; 95% CI 0.87–1.40; p = 0.39; I2 = 0%), and relapse-free survival (OR 1.08; 95% CI 0.78–1.51; p = 0.62; I2 = 0%).

Conclusion
This systematic review and meta-analysis found a significant difference in favor of the ACT group in terms of survival after pCR. Therefore, the administration of this treatment as adjuvant therapy should be encouraged in clinical practice.
Patterns and timing of recovery from facial nerve palsy after nerve-sparing parotid surgery: the role of neuromuscular retraining
Authors: Molinari Giulia , Calvaruso Federico , Barbazza Alice , Vanelli Elena , Nizzoli Federica , Reggiani Elena , Guidotti Monica , Borghi Aurora , Marchioni Daniele , Presutti Livio , Fernandez Ignacio Javier 
Published: June 2024

Abstract
Objectives
Among the complications of parotid surgery, facial palsy is frequent and burdened by high functional and social impact for the patient. There are few data on the efficacy of facial neuromuscular retraining (FNR) in patients with facial palsy after parotid surgery, and no data exist on its impact in timing and extent of recovery.

Material and methods
A retrospective study was conducted on patients undergoing FN sparing parotid surgery and suffering from postoperative facial palsy. Among 400 patients undergoing surgery between July 2016 and May 2023, those with the preservation of the FN and onset of facial palsy were selected. Nerve function was evaluated during 2 years follow up using the House-Brackman (H&Bs) and Sunnybrook scales (SBs).

Results
A total of 46 patients undergoing partial or total parotidectomy were included. At discharge 18 patients (39,1%) had IV to VI grade paralysis according to the H&Bs and the mean SBs value was 54. At 2 and 6 months after surgery, the average value of Sunnybrook increased to 76.5 and 95.4 respectively. After 12 months no patients with IV to VI grade paralysis were represent in our cohort. Two years after surgery, only five patients (10.9%) had persistent grade II paralysis according to HBs.

Conclusions
Our study supports the efficacy of FNR in the rehabilitation of facial paralysis after nerve-sparing parotidectomy. The greater functional improvement is achieved within the first 6 months of rehabilitation. A significant improvement is detected still after 18 months, supporting the importance of long rehabilitation for patients without complete recovery after the first year.
Glymphatic function from diffusion-tensor MRI to predict conversion from mild cognitive impairment to dementia in Parkinson’s disease
Authors: Pang Huize , Wang Juzhou , Yu Ziyang , Yu Hongmei , Li Xiaolu , Bu Shuting , Zhao Mengwan , Jiang Yueluan , Liu Yu , Fan Guoguang 
Published: June 2024

Abstract
Background
Although brain glymphatic dysfunction is a contributing factor to the cognitive deficits in Parkinson’s disease (PD), its role in the longitudinal progression of cognitive dysfunction remains unknown.

Objective
To investigate the glymphatic function in PD with mild cognitive impairment (MCI) that progresses to dementia (PDD) and to determine its predictive value in identifying individuals at high risk for developing dementia.

Methods
We included 64 patients with PD meeting criteria for MCI and categorized them as either progressed to PDD (converters) (n = 29) or did not progress to PDD (nonconverters) (n = 35), depending on whether they developed dementia during follow-up. Meanwhile, 35 age- and gender-matched healthy controls (HC) were included. Bilateral diffusion-tensor imaging analysis along the perivascular space (DTI-ALPS) indices and enlarged perivascular spaces (EPVS) volume fraction in bilateral centrum semiovale, basal ganglia (BG), and midbrain were compared among the three groups. Correlations among the DTI-ALPS index and EPVS, as well as cognitive performance were analyzed. Additionally, we investigated the mediation effect of EPVS on DTI-ALPS and cognitive function.

Results
PDD converters had lower cognitive composites scores in the executive domains than did nonconverters (P < 0.001). Besides, PDD converters had a significantly lower DTI-ALPS index in the left hemisphere (P < 0.001) and a larger volume fraction of BG-PVS (P = 0.03) compared to HC and PDD nonconverters. Lower DTI-ALPS index and increased BG-PVS volume fraction were associated with worse performance in the global cognitive performance and executive function. However, there was no significant mediating effect. Receiver operating characteristic analysis revealed that the DTI-ALPS could effectively identify PDD converters with an area under the curve (AUC) of 0.850.

Conclusion
The reduction of glymphatic activity, measured by the DTI-ALPS, could potentially be used as a non-invasive indicator in forecasting high risk of dementia conversion before the onset of dementia in PD patients.
Unravelling relationships between obesity, diabetes, and factors related to somatosensory functioning in knee osteoarthritis patients
Authors: Meert Lotte , Vervullens Sophie , Heusdens Christiaan H. W. , Smeets Rob J. E. M. , Meeus Mira , Mertens Michel G. C. A. M. 
Published: June 2024

Abstract
Objective
This study explores the association between obesity, diabetes, and somatosensory functioning in patients with knee osteoarthritis (OA), aiming to understand how metabolic conditions are related to pain mechanisms in this patient population. We hypothesized that higher body mass index (BMI), fat mass, and glycated hemoglobin levels (HbA1c) are associated with signs of altered somatosensory functioning.

Methods
A cross-sectional analysis was conducted as part of a larger multicentre prospective cohort study. Data were collected from patients awaiting total knee arthroplasty in Belgium and the Netherlands. Associations between BMI, fat mass, HbA1c, and various pain-related variables were examined employing Pearson and Spearman correlation analyses which were further analyzed with linear regression techniques.

Results
The study included 223 participants. Analysis revealed a significant although weak negative correlation between fat mass and pressure pain thresholds (PPT) at multiple locations, suggesting a link between higher fat mass and increased mechanical hyperalgesia. There were no significant correlations between BMI and pain-related outcomes. HbA1c levels showed very weak positive correlations with pain measures but did not withstand correction for multiple testing.

Conclusion
The findings indicate that fat mass may be closely associated with altered somatosensory functioning in patients with knee OA. However, no significant correlations were found between BMI or HbA1c levels and pain-related outcomes. Future research should focus on longitudinal studies to elucidate the causal relationships and further explore the impact of metabolic factors on pain mechanisms in this patient population.

Key Points• The findings indicate that fat mass may be closely associated with altered somatosensory functioning in patients with knee OA.
Comparing the productive vocabularies of grey parrots (Psittacus erithacus) and young children
Authors: Roubalová Tereza , Jarůšková Lucie , Chládková Kateřina , Lindová Jitka 
Published: June 2024

Abstract
Due to their outstanding ability of vocal imitation, parrots are often kept as pets. Research has shown that they do not just repeat human words. They can use words purposefully to label objects, persons, and animals, and they can even use conversational phrases in appropriate contexts. So far, the structure of pet parrots’ vocabularies and the difference between them and human vocabulary acquisition has been studied only in one individual. This study quantitatively analyses parrot and child vocabularies in a larger sample using a vocabulary coding method suitable for assessing the vocabulary structure in both species. We have explored the composition of word-like sounds produced by 21 grey parrots (Psittacus erithacus) kept as pets in Czech- or Slovak-speaking homes, and compared it to the composition of early productive vocabularies of 21 children acquiring Czech (aged 8–18 months), who were matched to the parrots by vocabulary size. The results show that the ‘vocabularies’ of talking grey parrots and children differ: children use significantly more object labels, activity and situation labels, and emotional expressions, while parrots produce significantly more conversational expressions, greetings, and multiword utterances in general. These differences could reflect a strong link between learning spoken words and understanding the underlying concepts, an ability seemingly unique to human children (and absent in parrots), but also different communicative goals of the two species.
Deep learning model using classification for diabetic retinopathy detection: an overview
Authors: Muthusamy Dharmalingam , Palani Parimala 
Published: June 2024

AbstractEarly detection of diabetic retinopathy is a serious disease for diabetics to minimize their sightlessness risks. The different approaches take a much longer time for a very large training dataset. In classifying to better the accuracy of diabetic retinopathy, a novel technique called MAP Concordance Regressive Camargo’s Index-Based Deep Multilayer Perceptive Learning Classification (MAPCRCI-DMPLC) has been introduced with minimum time consumption. The novel model of MAPCRCI-DMPLC comprises the input layer, hidden layers, and output layer for detecting diabetic retinopathy at an early stage through high accuracy and less moment consumption. The proposed MAPCRCI-DMPLC model collected the retinal fundus images from the dataset as input. After that, we carried out image preprocessing using the MAP-estimated local region filtering-based preprocessing technique in the first hidden layer. In the second hidden layer, Camargo’s index-based ROI extraction is performed to identify the infected region. Then, Concordance Correlative Regression is applied for texture feature extraction. Then the color feature is extracted, beginning the image. The features extracted to the output layer to classify the different levels of DR using the swish activation function through higher accuracy. An investigational assessment using a retinal image dataset on factors such as peak signal-to-noise ratio (PSNR), disease detection accuracy (DDA), false-positive rate (FPR), and disease detection time (DDT), regarding the quantity of retinal fundus images and image dimension. The quantitative and qualitatively analyzed outcome shows a better presentation of our proposed MAPCRCI-DMPLC technique when compared through the five state-of-the-art approaches.
The role of artificial intelligence algorithms in information systems research: a conceptual overview and avenues for research
Authors: Bendig David , Bräunche Antonio 
Published: June 2024

AbstractArtificial intelligence (AI) has made remarkable progress in the past decade. Despite the plethora of AI research, we lack an accrued overview of the extent to which management research uses AI algorithms. The context, purpose, and type of AI used in previous work remain unknown, though this information is critical to coordinating, extending, and strengthening the use of AI. We address this knowledge gap with a systematic literature review (SLR), focusing on 12 leading information systems (IS) journals and leveraging a customized generative pre-trained transformer (GPT) in our analyses. We propose a conceptual framework comprising eight dimensions to categorize our findings in terms of application areas, methods, and algorithms of applied AI, mitigating the lack of a concise AI taxonomy. Thus, we identify and discuss trends, outline underrepresented algorithms with significant potential, and derive research avenues. We extend the literature with a conceptual overview that may serve as a building block for theory building and further exploration of the evolving AI research domain.
Hypoxia Promotes the Stemness of Mesangiogenic Progenitor Cells and Prevents Osteogenic but not Angiogenic Differentiation
Authors: Burzi Irene Sofia , Parchi Paolo Domenico , Barachini Serena , Pardini Eleonora , Sardo Infirri Gisella , Montali Marina , Petrini Iacopo 
Published: June 2024

AbstractThe stem cell niche in the bone marrow is a hypoxic environment, where the low oxygen tension preserves the pluripotency of stem cells. We have identified mesangiogenic progenitor cells (MPC) exhibiting angiogenic and mesenchymal differentiation capabilities in vitro. The effect of hypoxia on MPC has not been previously explored. In this study, MPCs were isolated from volunteers' bone marrow and cultured under both normoxic and hypoxic conditions (3% O2). MPCs maintained their characteristic morphology and surface marker expression (CD18 + CD31 + CD90-CD73-) under hypoxia. However, hypoxic conditions led to reduced MPC proliferation in primary cultures and hindered their differentiation into mesenchymal stem cells (MSCs) upon exposure to differentiative medium. First passage MSCs derived from MPC appeared unaffected by hypoxia, exhibiting no discernible differences in proliferative potential or cell cycle. However, hypoxia impeded the subsequent osteogenic differentiation of MSCs, as evidenced by decreased hydroxyapatite deposition. Conversely, hypoxia did not impact the angiogenic differentiation potential of MPCs, as demonstrated by spheroid-based assays revealing comparable angiogenic sprouting and tube-like formation capabilities under both hypoxic and normoxic conditions. These findings indicate that hypoxia preserves the stemness phenotype of MPCs, inhibits their differentiation into MSCs, and hampers their osteogenic maturation while leaving their angiogenic potential unaffected. Our study sheds light on the intricate effects of hypoxia on bone marrow-derived MPCs and their differentiation pathways.
Graphical Abstract
Diagnostic value of immune-related biomarker FAM83A in differentiating malignant from benign pleural effusion in lung adenocarcinoma
Authors: Liu Hangfeng , Yao Jia , Liu Yulan , Wu Liping , Tan Zhiwei , Hu Jie , Chen Shigao , Zhang Xiaolin , Cheng Shuanghua 
Published: June 2024

Abstract
Background
Malignant pleural effusion (MPE) is frequently observed in patients with advanced lung adenocarcinoma (LUAD). Pleural fluid cytology is a less invasive procedure compared to pleural biopsy. Therefore, it is crucial to identify novel effective biomarkers for LUAD-associated pleural fluid cytology.

Methods
The RNA sequencing (RNA-Seq) and clinical data of LUAD cases were downloaded from TCGA and OncoSG databases. Differential gene expression analysis, survival analysis and immune cell infiltration analysis were performed on the LUAD datasets. The expression levels of FAM83A, TFF-1, and NapsinA in 94 paired LUAD and adjacent normal tissues, and in the pleural effusion specimens of 40 LUAD and 21 non-neoplastic patients were evaluated by immunohistochemistry.

Results
FAM83A expression levels were significantly different between the LUAD and normal tissue datasets, and correlated with overall or disease-free survival, and histological grade of the tumors. Furthermore, the in-situ expression of FAM83A was higher in 89/94 LUAD tissues compared to the paired normal tissues. FAM83A expression was significantly correlated with immune cell infiltration, and showed a positive association with macrophage infiltration. In addition, FAM83A staining was positive in 37 LUAD pleural effusion samples, and negative in 20 non-neoplastic pleural effusion samples. The expression pattern of FAM83A in the pleural effusion of LUAD patients was relatively consistent with that of TFF-1 and NapsinA, and even stronger in some specimens that were weakly positive or negative for TTF1/NapsinA.

Conclusions
FAM83A is a promising immune-related biomarker in LUAD biopsy specimens and pleural fluid, and can distinguish between malignant and benign pleural effusion.
Odour and indoor air quality hazards in railway cars: an Australian mixed methods case study
Authors: Chandra Shaneel , Bricknell Lisa , Makiela Sandrine , Bruce Sherie , Naweed Anjum 
Published: June 2024

Abstract
Purpose
This case study aimed to diagnose the cause(s) of a seasonal, and objectionable odour reported by travellers and drivers in the railway cars of Australian passenger trains. The research questions were to: (1) identify whether significant microbial colonisation was present within the air handling system of trains and causing the odours; to (2) identify other potential sources and; (3) remedial options for addressing the issue.

Methods
A mixed-methods, action research design was used adopted. Sections of the heating, ventilation, and air conditioning (HVAC) systems from odour-affected trains were swabbed for bacteria and fungi and examined for evidence of wear, fatigue and damage on-site and off-site. Insulation foam material extracted from the walls of affected trains was also subjected to a chemical assessment following exposure to varying humidity and temperature conditions in a climate simulator. This was accompanied by a qualitative sensory characterisation.

Results
Upon exposure to a variety of simulated temperature and humidity combinations to recreate the odour, volatile chemical compounds released from the insulation foam by water were identified as its likely cause. In addition, a range of potentially serious pathogenic and odour-causing microbes were cultured from the HVAC systems, although it is considered unlikely that bacterial colonies were the odour source.

Conclusion
The research has implications for the sanitising and maintenance policies for HVAC systems on public transport, especially when operating in humid environments. The sanitary imposition, especially in the wake of COVID-19 may be required to ensure the safety of the travelling public and drivers.
Guideline to Asses Geometrical Intolerance of Thin-Walled Blanks After Burnishing Process
Authors: Teimouri Reza 
Published: June 2024

AbstractApplication of lightweight material like aluminum alloy is increasing its importance in various industries due to effective reduction of structure weight and sequential advantages like reduction of greenhouse gas emission and carbon footprint. However, deflection of aluminum thin-walled blank during production by machining is a challenge that merits further studies. Burnishing as a non-metal removal finish-machining process is usually used as a final treatment in the production chain of samples. However, in burnishing of thin-walled structure, machining-induced residual stress causes dimensional and geometrical distortion followed by problems in manufacturing accuracy and mismatch in assembly. Therefore, to minimize the consequence of the abovementioned errors, the source of the distortion should be identified and minimized during machining since usually no further operation is placed in the production chain after burnishing. To effectively tackle this challenge, in the present study an analytical model is developed to find how the burnishing process factors i.e. pass number and static force together with initial blank size impact the distortion of thin-walled 6061-T6 plates. The curvatures which were derived from analytical model were compared to those of burnished samples measured by coordinate measuring machine. It was found from the results that the burnishing pass number because of its impact on work hardening and regeneration of stress together with blank size play crucial role on determining the sample’s distortion. It was obtained that with 2 pass burnishing results in minimizing the distortion of material. Moreover, the blank’s length to width ratio due to its impact on material stiffness in corresponding direction significantly impacts the deformation after unclamping. The results which were derived from analytical model were compatible well with experimental values in term of final distribution of residual stress and maximum height of distorted parts.