bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chromium Speciation in Environmental Samples by Solid-Phase Extraction Using Lewatit Ionac SR-7 Resin and Flame Atomic Absorption Spectrometry
Authors: Saçmaci Şerife , Kartal Şenol , Kumsuz Sevim 
Published: November 2014

Abstract
A new method for the speciation, preconcentration, and separation of Cr(III) and Cr(VI) species in different matrixes was developed using SPE combined with flame atomic absorption spectrometry. The procedure is based on the exchange of Cr(VI) ions as CrO42– with Cl– ions on Lewatit Ionac SR-7 ion-exchange resin. After the oxidation of Cr(III) to CrO42– ions by concentrated H2O2 in basic medium, the procedure was applied to the determination of total Cr. Cr(III) was calculated as the difference between the total Cr and Cr(VI) contents. The influence of the analytical parameters including the pH of the solution, amount of resin, eluent type, sample volume, and flow rates of the sample and eluent solutions were investigated. No considerable interferences were observed from other anions and cations investigated in the Cr speciation. The preconcentration factor was found to be 500. The LOD for Cr(VI), corresponding to three times the SD of the blank, was 0.003 μg/L. The sorption capacity and binding equilibrium constant were calculated as 17.2 mg/g and 2.54 L/mg, respectively. The accuracy of the method was verified by analyzing certified reference materials. The proposed method was applied to the speciation of Cr species in real samples with satisfactory results.
Electrochemical Determination of Catechin, Protocatechuic Acid, and L-Lactic Acid Based on Voltammetric Response of Ferroceneboronic Acid
Authors: Shi Wenxiu , Wang Junxia , Zhu Lei , Cai Meizhi , Du Xiaoyan 
Published: November 2014

Abstract
An electrochemical technique for the determination of catechin, protocatechuic acid, and L-lactic acid has been developed using ferroceneboronic acid (FBA) as an electrochemical probe. The principle is based on the changes in voltammograms of FBA associated with selective binding of the analytes to FBA. A cyclic voltammogram and a differential pulse voltammogram (DPV) of FBA were recorded on a glassy carbon electrode in the presence of the analytes. The oxidation or reduction peak currents of FBA were decreased in the presence of the analytes, depending on their concentrations. The DPV measurements provided useful calibration graphs in the concentration range of 0.5–4.0 × 10–3 M catechin, 0.1–1.2 × 10–5 M protocatechuic acid, and 0.5–40 × 10–5 M L-lactic acid. The proposed method was successfully applied to the analysis of catechin in abdominal pain water medicine.
Structural Elucidation of Potential Impurities in Azilsartan Bulk Drug by HPLC
Authors: Zhou Wentao , Zhou Yuxia , Sun Lili , Zou Qiaogen , Wei Ping , Ouyang Pingkai 
Published: November 2014

Abstract
During the synthesis of Azilsartan (AZS), it was speculated that 15 potential impurities would arise. This study investigated the possible mechanism for the formation of 14 of them, and their structures were characterized and confirmed by IR, NMR, and MS techniques. In addition, an efficient chromatographic method was developed to separate and quantify these impurities, using an Inertsil ODS-3 column (250 × 4.6 mm, 5 μm) in gradient mode with a mixture of acetonitrile and the potassium dihydrogen orthophosphate buffer (10 mM, pH adjusted to 3.0 with phosphoric acid). The HPLC method was validated for specificity, precision, accuracy, and sensitivity. LOQ of impurities were in the range of 1.04–2.20 ng. Correlation coefficient values of linearity were &gt;0.9996 for AZS and its impurities. The mean recoveries of all impurities in AZS were between 93.0 and 109.7%. Thus, the validated HPLC method is suitable for the separation and quantification of all potential impurities in AZS.
Crystal Diagnostics MultiPath System™
Authors: Stumpf Curtis H , Zhao Weidong , Bullard Brian , Ammons Christine , Devlin Karl I , Niehaus Gary D 
Published: November 2014

Abstract
The Crystal Diagnostics MultiPath System™ provides rapid detection of Escherichia coli O157 in fresh raw ground beef, raw beef trim, and spinach. The Crystal Diagnostics system combines patented Liquid Crystal technology with antibody-coated paramagnetic microspheres to selectively capture and detect E. coli O157 in food matrixes. This is the only liquid crystal-based biosensor commercially available for the detection of pathogens. The Crystal Diagnostics system expeditiously provides the sensitivity and accuracy of the U.S. Department of Agriculture Food Safety Inspection Service (USDA-FSIS) and the U.S. Food and Drug Administration Bacteriological Analytical Manual (FDA-BAM) methods for detecting as low as one CFU of E. coli O157 per 375 g of raw ground beef and raw beef trim, or 200 g of raw spinach. An internal inclusivity validation demonstrated detection of all 50 tested strains of E. coli O157. The internal and independent laboratory tests demonstrate that the method is rapid and sensitive for detecting of E. coli O157 in fresh raw ground beef, beef trim, and spinach.
Electrophoretic Separation of Alginic Sodium Diester and Sodium Hexametaphosphate in Chondroitin Sulfate that Interfere with the Cetylpyridinium Chloride Titration Assay
Authors: Zhang Weiguo , Giancaspro Gabriel , Adams Kristie M , Neal-Kababick James , Hildreth Jana , Li Aishan , Roman Mark C , Betz Joseph M 
Published: November 2014

Abstract
The most commonly used chondroitin sulfate (CS) assay method is cetylpyridinium chloride (CPC) titration. Cellulose acetate membrane electrophoresis (CAME) is the technique used for detection of impurities in the U.S. Pharmacopeia's CS monograph. Because CPC titration is a relatively nonspecific quantitative technique, the apparent amount of CS as determined by CPC titration alone may not reflect the true amount of CS due to possible interference with the CPC assay by impurities that contain CPC titratable functional groups. When CAME is used in conjunction with CPC titration, certain non-CS and adulterants can be visualized and estimated, and a true value for CS can be assigned once the presence of these non-CS impurities has been ruled out. This study examines conjunct application of CPC and CAME in ascertaining CS assay and purity in the presence of certain adulterants. These include propylene glycol alginate sulfate sodium, known in commerce as alginic sodium diester (ASD), and Zero One (Z1), a water-soluble agent newly reported in the CS marketplace and subsequently identified as sodium hexametaphosphate. ASD, Z1, and CS are similar in physical appearance and solubility in water and ethanol. They are also titratable anions and form ionic pairs with CPC, therefore interfering with the CPC titration assay for CS. CAME separates these adulterants from each other and from CS by differences in their electrophoretic mobility. CAME is able to detect these impurities in CS at levels as low as 0.66% by weight. Although it is recommended that a method for detecting impurities (e.g., CAME) be used in combination with relatively nonspecific assay methods such as CPC titration, this is seldom done in practice. Assay results for CS derived from CPC titration may, therefore, be misleading, leaving the CS supply chain vulnerable to adulteration. In this study, the authors investigated ASD and Z1 adulteration of CS and developed an electrophoretic separation of these adulterants in CS and procedures to isolate ASD from CS matrixes containing these adulterants. The authors describe in this paper utilization of an orthogonal approach to establish the identity of Z1 as sodium hexametaphosphate and to confirm the identity of ASD, including ethanol fractionation, FTIR spectroscopy, differential scanning calorimetry, and NMR spectroscopy. The authors suggest that CAME is a cost-effective and easy to use method for detecting certain impurities in CS raw ingredients and recommend that CPC and CAME be used in combination by QC laboratories as a means of effectively deterring the practice of adulterating CS raw materials with the known adulterants ASD and Z1 and/or other non-chondroitin substances that can be separated from CS by CAME and that exhibit CPC titration behavior similar to CS.
The Diagnostic Accuracy of Percutaneous Renal Needle Core Biopsy and Its Potential Impact on the Clinical Management of Renal Cortical Neoplasms
Authors: Gellert Lan L. , Mehra Rohit , Chen Ying-Bei , Gopalan Anuradha , Fine Samson W. , Al-Ahmadie Hikmat , Reuter Victor E. , Tickoo Satish K. 
Published: November 2014

Context
While biopsies are now increasingly being performed for the diagnosis of renal cortical neoplasms, the influence of the rendered pathological diagnoses on the clinical management is only rarely documented.

Objectives
To report our experience with consecutively performed renal biopsies and the potential impact of the diagnosis on subsequent clinical management.

Design
Material from needle biopsies performed consecutively at our institution between 2006 and 2011 was reviewed. The influence of the reported pathology results on the clinical management was determined from patient follow-up medical record review.

Results
In total, 218 percutaneous biopsies for renal masses were performed during this period. Among them, 181 (83%) yielded neoplastic tissue, including 81 clear cell renal cell carcinomas, 29 low-grade oncocytic neoplasms, 7 papillary renal cell carcinomas, 5 clear cell papillary renal cell carcinomas, 5 angiomyolipomas, and 14 urothelial carcinomas. Fourteen additional cases (6%) contained lesional material from clinically known nonneoplastic processes, for a total diagnostic yield of 89%. Twenty-three (11%) were nonrepresentative of lesional tissue. In 10 of these, repeat biopsies or resections established the diagnosis of renal tumors. Biopsy diagnosis was confirmed in 29 of 30 cases (97%) on subsequent nephrectomy. Following the biopsy diagnosis, there were significant differences in the clinical management; overall, 79% of clear cell renal cell carcinomas received therapeutic interventions, and 17% were put on active surveillance. In contrast, 77% of the benign or low-grade lesions were put on active surveillance.

Conclusions
Accurate and specific diagnosis can be rendered on renal core biopsy in most renal tumors, and the biopsy diagnosis can have a definitive role in their clinical management.
Comparison of Anti-Xa and Dilute Russell Viper Venom Time Assays in Quantifying Drug Levels in Patients on Therapeutic Doses of Rivaroxaban
Authors: Gosselin Robert C. , (Adcock) Funk Dorothy M. , Taylor J. Michael , Francart Suzanne J. , Hawes Emily M. , Friedman Kenneth D. , Moll Stephan 
Published: November 2014

Context
Rivaroxaban is a new oral anticoagulant that functions as a direct anti-Xa inhibitor. Although routine monitoring is not required, measurement of plasma concentrations may be necessary in certain clinical situations. Routine coagulation assays, such as the prothrombin time and, to a lesser degree, activated partial thromboplastin time, correlate with drug concentration, but because of reagent variability, these methods are not reliable for determining rivaroxaban anticoagulation.

Objective
To compare different methods and calibrators for measuring rivaroxaban, including the chromogenic anti-Xa assay, which, when calibrated with a rivaroxaban standard, may be more appropriate for determining anticoagulation.

Design
We compared measured rivaroxaban concentrations with the same anti-Xa kit but used different calibrators, with different anti-Xa kits but the same calibrators, with antithrombin-supplemented anti-Xa kit versus nonsupplemented kits, and with 2 methods based on rivaroxaban-calibrated, high-phospholipid, dilute Russell viper venom time. Regression and paired t test statistics were used to determine correlation and significant differences among methods and calibrator sources.

Results
Although there was strong correlation, statistically significant biases existed among methods that report rivaroxaban levels. A single-source calibrator did not alleviate those differences among methods. High-phospholipid Russell viper venom reagents correlated with rivaroxaban concentration but were not better than chromogenic anti-Xa methods.

Conclusions
Rivaroxaban-calibrated, anti-Xa measurements correlate well, but the clinical significance of the variation with rivaroxaban measurements is uncertain. The antithrombin-supplemented, anti-Xa method should be avoided for measuring rivaroxaban.
The Snow-Capped Mountain and the Uranium Mine
Authors: Colwell Chip , Ferguson T. J. 
Published: November 2014

AbstractKnown in English as Mount Taylor, Dewankwin Kyaba:chu Yalanne (“in the east snow-capped mountain”) in northwestern New Mexico is a sacred landscape to the Zuni people. From an archaeological perspective, the mountain is dotted with hundreds of discrete archaeological sites that record 12,000 years of history. From a Zuni perspective, Mount Taylor is a rich cultural landscape—a tangible record of ancestral migrations, a living being, a pilgrimage site, a referent in religious prayers, a spiritual source of rain, and a collecting place for spring water, animals, minerals, and plants. For Zunis, all of these facets of the mountain combine to create a “total landscape” that is both a source and an instrument of Zuni culture. This article presents a case study of a compliance project to document the potential impacts of a proposed uranium mine at the base of Mount Taylor on Zuni traditional cultural properties. The project demonstrates how archaeologists can benefit from a landscape perspective that builds from the traditional knowledge of descendant communities. The Zuni standpoint further helps shape a CRM practice that is anthropologically informed and consistent with a developing federal mandate to use landscape-scale analysis in heritage management and mitigation practices.
Image Analysis in Quantitative Particle Studies of Archaeological Ceramic Thin Sections
Authors: Reedy Chandra L. , Anderson Jenifer , Reedy Terry J. , Liu Yimeng 
Published: November 2014

AbstractThin-section petrography is a crucial tool for the study of archaeological ceramics, and in recent years, image analysis has emerged as a powerful quantitative enhancement of that tool. Exploratory applications of image analysis to archaeological ceramic thin sections, and related work by sedimentary geologists, have indicated its usefulness to the field. In this paper, we first present the results of experimental work testing the consistency and reproducibility of image analysis. We identify procedures for fast and reliable analysis of thin sections using laboratory-prepared ceramic specimens of simple clay-sand systems. We then show how those procedures can be slightly modified to accommodate more complex archaeological specimens. We conclude with a discussion of the role of image analysis within the overall context of thin-section petrography of ceramic materials, as one among a repertoire of techniques, adding quantitative data and increasing the usefulness of ceramic thin sections for addressing archaeological research questions.
Representation and Structure Conflict in the Digital Age
Authors: Carlson Eric S. 
Published: November 2014

AbstractDigital imaging technologies have enhanced archaeological research and profoundly expanded the scale of the discipline’s potentialities. As illustrators and archaeologists move away from using hand-drawn images (of hand-held, real-life objects) to depict artifacts and other archaeological information, certain capabilities of the traditional illustrative process are lost. One such loss is the ability to present a complete and informed representation of an artifact free of the distortions and visual limitations that single-perspective (i.e., digital or photographic) imagery produces. This is accomplished by the illustrator through the unification of multiple views of the artifact from various perspectives into a single two-dimensional image that communicates to the viewer important attributes of the artifact, free of distortion and remaining true to the measured, analytical conventions of the illustrative process. Liberation from the single-viewpoint perspective was one of the fundamental elements of the Cubist movement. Traditional archaeological illustrators utilize Cubist principles to communicate visually to the viewer a complete, accurate, and undistorted package of information about an artifact. The supplanting of hand-drawn illustrations by digital images in today’s archaeological publications threatens to revert the visual representation of data back to uninformed, surficial “snapshots” of incomplete objects.
Three-Dimensional Alternatives to Lithic Illustration
Authors: Magnani Matthew 
Published: November 2014

AbstractAlthough alternatives have become available, pen and ink drawings of stone tools dominate archaeological publications. Despite the existence of a conventional illustration framework, the work produced by illustrators can be inconsistent and hinges on skill level and time commitment. Discussions going back to the 1880s critically question the use of illustrations for the purpose of scientific publication. Alternatives, such as laser scanning and photogrammetric modeling, are now available for displaying lithics. These alternatives can remove the subjectivity involved in artistic rendering, creating replicable results, regardless of who is collecting the data. In addition to creating more regularized and objective representations, there are a significant number of analytical and other benefits to adopting novel imaging techniques to depict stone tools in publications. A set of three-dimensional (3D) models are presented here to demonstrate the capabilities of laser scanning and, potentially, photogrammetric modeling as replacements for lithic illustration.
Quantitative Measures of Wealth Inequality in Ancient Central Mexican Communities
Authors: Smith Michael E. , Dennehy Timothy , Kamp-Whittaker April , Colon Emily , Harkness Rebecca 
Published: November 2014

AbstractIssues of social and economic inequality are increasingly becoming areas of study for archaeologists; however, little work has been done on the uniform application of analytical methods. Here we assess the use of the Gini index for determining wealth inequality in eight Prehispanic central Mexican contexts. We analyze house size at the Late Postclassic sites of Capilco (village), Cuexcomate (town), and Yautepec (city), all in the state of Morelos. Agricultural field sizes for two communities described in a Nahuatl-language census immediately after the Spanish conquest are also analyzed. Our final context is the Xolalpan phase apartment compounds at Teotihuacan. Using these case studies we discuss methodological issues concerning the use of Gini indices to infer social inequality with archaeological data. We find that the Gini index, when applied following the proposed methodological standards, serves as a useful tool for the quantification of inequality across multiple archaeological case studies.
The mantle transition zone beneath West Antarctica: Seismic evidence for hydration and thermal upwellings
Authors: Emry E. L. , Nyblade A. A. , Julià J. , Anandakrishnan S. , Aster R. C. , Wiens D. A. , Huerta A. D. , Wilson T. J. 
Published: November 2014

AbstractAlthough prior work suggests that a mantle plume is associated with Cenozoic rifting and volcanism in West Antarctica, the existence of a plume remains conjectural. Here we use P wave receiver functions (PRFs) from the Antarctic POLENET array to estimate mantle transition zone thickness, which is sensitive to temperature perturbations, throughout previously unstudied parts of West Antarctica. We obtain over 8000 high‐quality PRFs using an iterative, time domain deconvolution method filtered with a Gaussian width of 0.5 and 1.0, corresponding to frequencies less than ∼0.24 and ∼0.48 Hz, respectively. Single‐station and common conversion point stacks, migrated to depth using the AK135 velocity model, indicate that mantle transition zone thickness throughout most of West Antarctica does not differ significantly from the global average, except in two locations; one small region exhibits a vertically thinned (210 ± 15 km) transition zone beneath the Ruppert Coast of Marie Byrd Land and another laterally broader region shows slight, vertical thinning (225 ± 25 km) beneath the Bentley Subglacial Trench. We also observe the 520 discontinuity and a prominent negative peak above the mantle transition zone throughout much of West Antarctica. These results suggest that the mantle transition zone may be hotter than average in two places, possibly due to upwelling from the lower mantle, but not broadly across West Antarctica. Furthermore, we propose that the transition zone may be hydrated due to >100 million years of subduction beneath the region during the early Mesozoic.
Electron distribution functions in the electron diffusion region of magnetic reconnection: Physics behind the fine structures
Authors: Bessho N. , Chen L.‐J. , Shuster J. R. , Wang S. 
Published: November 2014

AbstractHighly structured electron distribution functions in the electron diffusion region (EDR) during magnetic reconnection are studied by means of fully kinetic simulations. Four types of structures (striations, arcs, swirls, and rings) in momentum space are analyzed to understand their formation mechanisms. Discrete striations are formed by particles undergoing different numbers of meandering bounces in the EDR and are a result of oscillations in the out‐of‐plane force on meandering electrons. Predictions for the separation between striations and the triangular shape of the distribution are obtained analytically. Arcs and swirls are due to partial remagnetization of accelerated electrons. Near the end of the outflow jet, electron remagnetization gives rise to the ring structure. Understanding the distribution structures is critical to unraveling the kinetic processes occurring in the EDR and will guide the identification of EDRs based on satellite measurements.
Quantifying flow regimes in a Greenland glacial fjord using iceberg drifters
Authors: Sutherland David A. , Roth George E. , Hamilton Gordon S. , Mernild Sebastian H. , Stearns Leigh A. , Straneo Fiammetta 
Published: November 2014

AbstractLarge, deep‐keeled icebergs are ubiquitous in Greenland's outlet glacial fjords. Here we use the movement of these icebergs to quantify flow variability in Sermilik Fjord, southeast Greenland, from the ice mélange through the fjord to the shelf. In the ice mélange, a proglacial mixture of sea ice and icebergs, we find that icebergs consistently track the glacier speed, with slightly faster speeds near terminus and episodic increases due to calving events. In the fjord, icebergs accurately capture synoptic circulation driven by both along‐fjord and along‐shelf winds. Recirculation and in‐/out‐fjord variations occur throughout the fjord more frequently than previously reported, suggesting that across‐fjord velocity gradients cannot be ignored. Once on the shelf, icebergs move southeastward in the East Greenland Coastal Current, providing wintertime observations of this freshwater pathway.