bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hot But Not Cold Water Immersion Mitigates the Decline in Rate of Force Development Following Exercise-Induced Muscle Damage
Authors: BENOÎT SAUTILLET , NICOLAS BOURDILLON , GRÉGOIRE MILLET P. , FRANÇOIS BILLAUT , ABDELLAH HASSAR , HICHAM MOUFTI , SAÏD AHMAÏDI , GUILLAUME COSTALAT 
Published: July 2024

ABSTRACT

Purpose
In recent years, there has been significant advancement in the guidelines for recovery protocols involving heat or cold water immersion. However, comparison between the effects of hot and cold water immersion on key markers of neuromuscular recovery following exercise-induced muscle damage (EIMD) is lacking.

Methods
Thirty physically active males completed an individualized and tailored EIMD protocol immediately followed by one of the following recovery interventions: cold water immersion (11°C, CWI11), hot water immersion (41°C, HWI41), or warm-bath control (36°C, CON36). Gastrointestinal temperature was tracked throughout HWI41. Knee extensors’ maximal isokinetic strength (peak torque (T
peak)) and explosive strength (late-phase rate of force development (RFD100–200)) were measured before EIMD (pre-), 24 h (post-24 h), and 48 h (post-48 h) post-EIMD. In addition, pressure pain threshold (PPT) was measured to quantify the recovery from muscle soreness. Surface electromyography signals (sEMG) from the vastus lateralis were captured to extract the rates of electromyography rise (REMGR) and the spectral power in the low-frequency band.

Results
At post-48 h, T
peak returned to baseline values following both CWI11 (−8.3% ± 6.8%, P = 0.079) and HWI41 (−1.4% ± 4.1%, P = 1). In contrast, RFD100–200 (−2.3% ± 29.3%, P = 1) and PPT (+5.6% ± 14.6%, P = 1) returned to baseline values at post-48 h only following HWI41. Spectral analysis of the sEMG signal revealed that the low-frequency band was significantly increased following CWI11 (+9.0% ± 0.52%, P = 0.012). REMGR was unchanged regardless of the condition (all P > 0.05).

Conclusions
A single session of HWI41, rather than CWI11, improved the recovery of the late-phase rate of force development following EIMD in physically active males. This suggests that in athletic contexts where a rapid force development is a key performance determinant, hot bath should be preferred over cold bath.
Suitability, usability and safety of fully immersive Virtual Reality applications for motor and cognitive rehabilitation in stroke patients preliminary data.
Authors: Roussou Georgia , Despoti Akylina , Patsaki Irini , Tzoumi Dimitra , Leventakis Nikolaos , Dimitriadi Nefeli , Papathanasiou Argyro , Alexandropoulou Anna , Nanas Serafeim , Karatzanos Eleftherios 
Published: July 2024

Background: The use of immersive Virtual Reality (VR) in stroke rehabilitation appears to be promising for the improvement of motor and cognitive functions.
Methods: The purpose of this pilot study was to investigate the suitability, usability and safety of VR applications that combine motor and cognitive training. Patients suffering from stroke in a subacute phase, and with Mini Mental State Examination (MMSE) ≥18/30, participated in the study. In the context of the REACT project, two IVR applications were designed and created, combining the use of motor and cognitive skills. Full immersion was achieved using the Head Mounted Display (HMD) Oculus Rift S. The intervention lasted for 4 weeks. The Suitability Evaluation Questionnaire (SEQ) was used for measurements. Values are expressed in the median (25th-75th percentile).
Results: Four patients [age: 64.5(61.0-69.5) years, gender:1 female / 3 male] in the 3rd-14th week of rehabilitation were finally included. Overall, the patient's SEQ score was 61(55-63). No adverse effects were reported, only one patient reported mild confusion 5.0(4.8-5.0) in one assessment. No differences were found in the comparison between first and second evaluation [61(58-62) vs 61(48-64), p>0.05].
Conclusions: The primary results of this study show that the equipment is usable, safe, and suitable for use in the rehabilitation of patients with stroke in the early stages of rehabilitation. However, more large-scale studies are needed to investigate the validity and effects of VR applications in the neurorehabilitation of various disorders.
Navigating Platform-Led Affiliate Marketing: Implications for Content Creation and Platform Profitability
Authors: Gu Meilin , Liu Dengpan , Kumar Subodha 
Published: July 2024

Practice- and Policy-Oriented Abstract Recently, some user-generated content (UGC) platforms have introduced shopping features to generate additional commission-based revenue from in-app transactions. These platforms allow creators to produce shoppable content, where promoted products are tagged with affiliate links, and in return, they earn a percentage of the commission the creators receive from merchants This paper aims to investigate the impact of this platform-led affiliate marketing business model on the key stakeholders. Employing a game-theoretic model, our study demonstrates that platform-led affiliate marketing can create a win-win situation for UGC platforms, creators participating in affiliate marketing, and consumers. Furthermore, even creators not participating in affiliate marketing can sometimes benefit indirectly from other creators’ participation. However, we find that platforms may not necessarily benefit from adopting this emerging business model because of potential losses in traffic revenue. These results carry significant managerial implications for platforms regarding whether and how to leverage affiliate marketing. Moreover, our findings suggest that creators may benefit from reducing their production efforts in the face of intensified competition. More importantly, optimal production decisions for creators can vary significantly, depending on specific factors contributing to heightened competition. These findings offer valuable insights that can guide creators in refining their production strategies.
Correlation and predictive value of pathological complete response and ultrasound characteristic parameters in neoadjuvant chemotherapy for breast
Authors: Zheng Lei , Yang Li-Xian , Liu Jing-Yi , Jiang Zhe , Li Xiao-Wei , Pu Peng-Peng 
Published: July 2024

BACKGROUND
Breast cancer ranks as one of the most prevalent malignant tumors among women, significantly endangering their health and lives. While radical surgery has been a pivotal method for halting disease progression, it alone is insufficient for enhancing the quality of life for patients.
AIM
To investigate the correlation between ultrasound characteristic parameters of breast cancer lesions and clinical efficacy in patients undergoing neoadjuvant chemotherapy (NAC).
METHODS
Employing a case-control study design, this research involved 178 breast cancer patients treated with NAC at our hospital from July 2019 to June 2022. According to the Miller-Payne grading system, the pathological response, i.e. efficacy, of the NAC in the initial breast lesion after NAC was evaluated. Of these, 59 patients achieved a pathological complete response (PCR), while 119 did not (non-PCR group). Ultrasound characteristics prior to NAC were compared between these groups, and the association of various factors with NAC efficacy was analyzed using univariate and multivariate approaches.
RESULTS
In the PCR group, the incidence of posterior echo attenuation, lesion diameter ≥ 2.0 cm, and Alder blood flow grade ≥ II were significantly lower compared to the non-PCR group (P < 0.05). The area under the curve values for predicting NAC efficacy using posterior echo attenuation, lesion diameter, and Alder grade were 0.604, 0.603, and 0.583, respectively. Also, rates of pathological stage II, lymph node metastasis, vascular invasion, and positive Ki-67 expression were significantly lower in the PCR group (P < 0.05). Logistic regression analysis identified posterior echo attenuation, lesion diameter ≥ 2.0 cm, Alder blood flow grade ≥ II, pathological stage III, vascular invasion, and positive Ki-67 expression as independent predictors of poor response to NAC in breast cancer patients (P < 0.05).
CONCLUSION
While ultrasound characteristics such as posterior echo attenuation, lesion diameter ≥ 2.0 cm, and Alder blood flow grade ≥ II exhibit limited predictive value for NAC efficacy, they are significantly associated with poor response to NAC in breast cancer patients.
Effects of pulmonary surfactant combined with noninvasive positive pressure ventilation in neonates with respiratory distress syndrome
Authors: Shi Ze-Ning , Zhang Xin , Du Chun-Yuan , Zhao Bing , Liu Shu-Gang 
Published: July 2024

BACKGROUND
Neonatal respiratory distress syndrome (NRDS) is one of the most common diseases in neonatal intensive care units, with an incidence rate of about 7% among infants. Additionally, it is a leading cause of neonatal death in hospitals in China. The main mechanism of the disease is hypoxemia and hypercapnia caused by lack of surfactant
AIM
To explore the effect of pulmonary surfactant (PS) combined with noninvasive positive pressure ventilation on keratin-14 (KRT-14) and endothelin-1 (ET-1) levels in peripheral blood and the effectiveness in treating NRDS.
METHODS
Altogether 137 neonates with respiratory distress syndrome treated in our hospital from April 2019 to July 2021 were included. Of these, 64 control cases were treated with noninvasive positive pressure ventilation and 73 observation cases were treated with PS combined with noninvasive positive pressure ventilation. The expression of KRT-14 and ET-1 in the two groups was compared. The deaths, complications, and PaO2, PaCO2, and PaO2/FiO2 blood gas indexes in the two groups were compared. Receiver operating characteristic curve (ROC) analysis was used to determine the diagnostic value of KRT-14 and ET-1 in the treatment of NRDS.
RESULTS
The observation group had a significantly higher effectiveness rate than the control group. There was no significant difference between the two groups in terms of neonatal mortality and adverse reactions, such as bronchial dysplasia, cyanosis, and shortness of breath. After treatment, the levels of PaO2 and PaO2/FiO2 in both groups were significantly higher than before treatment, while the level of PaCO2 was significantly lower. After treatment, the observation group had significantly higher levels of PaO2 and PaO2/FiO2 than the control group, while PaCO2 was notably lower in the observation group. After treatment, the KRT-14 and ET-1 levels in both groups were significantly decreased compared with the pre-treatment levels. The observation group had a reduction of KRT-14 and ET-1 levels than the control group. ROC curve analysis showed that the area under the curve (AUC) of KRT-14 was 0.791, and the AUC of ET-1 was 0.816.
CONCLUSION
Combining PS with noninvasive positive pressure ventilation significantly improved the effectiveness of NRDS therapy. KRT-14 and ET-1 levels may have potential as therapeutic and diagnostic indicators.
Cushing's syndrome caused by giant Ewing's sarcoma of the kidney: A case report and review of literature
Authors: Dong Guo-Fan , Hou Ya-Kun , Ma Qi , Ma Shuang-Yu , Wang Yu-Jie , Rexiati Mulati , Wang Wen-Guang 
Published: July 2024

BACKGROUND
Primary renal Ewing’s sarcoma (ES) is extremely rare, and only two cases causing Cushing’s syndrome (CS) have been reported to date. We report that the case of an 18-year-old patient is diagnosed primary renal ES with typical CS characterized by purple stripes, weight gain, and hypertension.
CASE SUMMARY
CS was first diagnosed by laboratory testing. A huge tumor was revealed in the kidney following an imaging examination. Moreover, brain and bone metastases were observed. After comprehensive treatment, primarily based on surgery, primary renal ES was pathologically diagnosed with a typical EWSR1-FLI1 genetic mutation through genetic testing. Furthermore, the glucocorticoid level returned to normal. By the ninth postoperative month of follow-up, the patient was recovering well. Cushing-related symptoms had improved, and a satisfactory curative effect was achieved.
CONCLUSION
Primary renal ES, a rare adult malignant tumor, can cause CS and a poor prognosis.
Rare extraintestinal manifestations of ulcerative colitis treated with dual biologic therapy: A case report
Authors: Filipiuk Aleksandra , Gonciarz Maciej 
Published: July 2024

BACKGROUND
Ulcerative colitis (UC) is an idiopathic, chronic inflammatory bowel disease (IBD) most often located in the rectum, but may involve the entire colon. Extra intestinal manifestations (EIMs) occur with varying frequency depending on the affected organ. The most common ones are musculoskeletal EIMs, affecting up to 33%-40% of IBD patients. These include, among others, inflammatory back pain, tendinitis, plantar fasciitis and arthritis. Only a few case reports in literature discuss Achilles tendinitis.
CASE SUMMARY
This report describes a patient with UC and Achilles tendinitis in whom after many unsuccessful attempts of treatment with sulfasalazine, mesalazine, glucocorticosteroids, infliximab and tofacitinib, a complete UC remission and resolution of Achilles tendinitis were achieved with the use of dual biologic therapy (DBT)-ustekinumab and adalimumab (ADA).
CONCLUSION
This case mentions rare EIMs of UC and suggests that DBT may be an alternative for patient with ulcerative colitis and EIMs.
Raman parametric four-wave mixing mechanism of the first-order Stokes generated in CO2 and H2
Authors: Sun Jinglu , Cai Xianglong , Xu Ming , Guo Jingwei 
Published: July 2024

Without the axial component, an annular spatial profile of the first-order Stokes (S1) was observed during the SRS process in low-energy pumped CO2 gas, which is supposed to be generated by a parametric four-wave mixing process (PFWM), i.e., 2

ω

P

=

ω

AS
1 +

ω

S
1. In order to verify such a mechanism, similar experiments were conducted in H2, and the annular S1 intensity distribution was also noticed. Furthermore, simulations of S1 radial intensity distributions were carried out based on the proposed PFWM phase matching geometry. The PFWM has been verified to be a process that directly annihilates two pump photons and simultaneously produces one AS1 photon and one S1 photon.
Case detection delay in leprosy: Testing tool reliability and measurement consistency in Ethiopia, Mozambique, and Tanzania
Authors: Mamo Ephrem , van Wijk Robin , Schoenmakers Anne , Bobosha Kidist , Legesse Mengistu , Hambridge Thomas , Debelo Kitesa , Daba Fufa , Mwageni Nelly , Marega Abdoulaye , Letta Taye , Eman Ahmed Mohammed , Fumane Banú , Rassolo Helder , Njako Blasdus Franz , E. Mshana Stephen , Richardus Jan Hendrik , Kasang Christa , Mieras Liesbeth 
Published: July 2024

Background
Case detection delay (CDD) in leprosy is defined as the period between the onset of the first signs and symptoms and the time of diagnosis. A tool, consisting of a questionnaire and a detailed guide for researchers, which includes photos of typical skin signs and notes on establishing the timing of events, was developed to determine this period of delay in months in recently diagnosed leprosy patients. The aims of the study were to determine the reliability and consistency of this CDD assessment tool.

Methods
This study was conducted in Ethiopia, Mozambique and Tanzania. Two types of consistency were considered: over time (test-retest reliability) and across different researchers (interrater reliability). A CDD questionnaire was administered to 167 leprosy patients who were diagnosed within 6 months prior to their inclusion. One month later, the same or another researcher re-administered the CDD questionnaire to the same patients. Both test-retest and interrater reliability were assessed using the intraclass correlation coefficient (ICC), where a value greater than or equal to 0.7 is considered acceptable.

Results
In this study, 10 participants (6.0%) were under 15 years of age, and 56 (33.5%) were women. In the test-retest assessment, the mean CDD from the first and second interviews was 23.7 months (95% CI 14.4–34.8) and 24.0 months (95% CI 14.8–33.2), respectively. The ICC for test-retest reliability was 0.99 (95% CI 0.994–0.997). For the interrater reliability assessment, the first and second interviews revealed a mean CDD of 24.7 months (95% CI 18.2–31.1) and 24.6 months (95% CI 18.7–30.5), respectively, with an ICC of 0.90 (95% CI 0.85–0.94). A standard error of measurement of 0.46 months was found in the test-retest and 1.03 months in the interrater measurement. Most answers given by participants during the first and second interviews were matching (≥86%). Most non-matching answers were in the 0–2 month delay category (≥46%).

Conclusion
The tool, including a questionnaire to determine the CDD of newly diagnosed leprosy patients, was validated in three African countries. The test-retest and interrater measurements demonstrated that the instrument is reliable and measures consistently. The tool can be used in routine leprosy programmes as well as in research settings.

Trial registration
This trial is registered with The Netherlands Trial Register (NTR), now available via International Clinical Trial Registry Platform (ICTRP) with registration number NL7294 (NTR7503), as well as with The Pan African Clinical Trials Registry (PACTR) with registration number PACTR202303742093429.
Vagal predominance correlates with mood state changes of winter-over expeditioners during prolonged Antarctic residence
Authors: Liu Shiying , Wang Jianan , Chen Shaoling , Chai Jiamin , Wen Jigang , Tian Xuan , Chen Nan , Xu Chengli 
Published: July 2024

Objective
Winter-over expeditioners in Antarctica are challenged by various environmental and psycho-social stress factors, which may induce psychophysiological changes. The autonomic nervous system (ANS) plays a crucial role in the adaptation process under stress. However, the relationship between ANS activity and the mood states of expeditioners remains largely unexplored. This study aims to uncover the pattern of ANS adjustment under extreme Antarctic environments and provide new insights into the correlations between ANS activity and mood state changes, which may provide scientific data for medical interventions.

Methods
Fourteen expeditioners at Zhongshan Station participated in this study. The study was conducted during four representative periods: pre-Antarctica, Antarctica-1 (pre-winter), Antarctica-2 (winter), and Antarctica-3 (summer). The heart rate variability (HRV) of the expeditioners was continuously measured for 24 hours to evaluate ANS activity. Plasma levels of catecholamines were tested by ELISA. Mood states were assessed by the Profile of Mood States (POMS) scale.

Results
HRV analysis showed a disturbance of ANS during winter and summer periods. For frequency domain parameters, very low frequency (VLF), low frequency (LF), high frequency (HF), and total power (TP) significantly increased during the second half of the mission. Especially, LF/HF ratio decreased during summer, indicating the predominance of vagal tone. Results of the time domain analysis showed increased heart rate variability during the austral winter and summer. Plasma epinephrine (E) significantly increased during residence in Antarctica. Compared with pre-Antarctica, the vigor, depression, and anger scores of the expeditioners decreased significantly during the austral summer. Notably, the depression score showed a moderate positive correlation with LF/HF, while weak negative correlations with other HRV indicators, including TP, VLF, and LF. Anger score showed a moderate positive correlation with LF/HF and weak negative correlations with the average normal-to-normal (NN) interval, and the root mean square of differences between adjacent RR intervals (RMSSD). Plasma E level weakly correlated with the average NN interval.

Conclusion
Prolonged residence in Antarctica increased the ANS activities and shifted the cardiac autonomic modulation towards vagal predominance. The alteration of HRV correlated with mood states and plasma epinephrine levels.
Association of poverty-income ratio with cardiovascular disease and mortality in cancer survivors in the United States
Authors: Yogeswaran Vidhushei , Kim Youngdeok , Franco R. Lee , Lucas Alexander R. , Sutton Arnethea L. , LaRose Jessica G. , Kenyon Jonathan , D’Agostino Ralph B. , Sheppard Vanessa B. , Reding Kerryn , Hundley W. Gregory , Cheng Richard K. 
Published: July 2024

BackgroundLower income is associated with high incident cardiovascular disease (CVD) and mortality. CVD is an important cause of morbidity and mortality in cancer survivors. However, there is limited research on the association between income, CVD, and mortality in this population.MethodsThis study utilized nationally representative data from the National Health and Nutrition Examination Survey (NHANES), a cross-sectional survey evaluating the health and nutritional status of the US population. Our study included NHANES participants aged ≥20 years from 2003–2014, who self-reported a history of cancer. We evaluated the association between income level, prevalence of CVD, and all-cause mortality. All-cause mortality data was obtained through public use mortality files. Income level was assessed by poverty-income ratio (PIR) that was calculated by dividing family (or individual) income by poverty guideline. We used multivariable-adjusted Cox proportional hazard models through a backward elimination method to evaluate associations between PIR, CVD, and all-cause mortality in cancer survivors.ResultsThis cohort included 2,464 cancer survivors with a mean age of 62 (42% male) years. Compared with individuals with a higher PIR tertiles, those in the lowest PIR tertile had a higher rate of pre-existing CVD and post-acquired CVD. In participants with post-acquired CVD, the lowest PIR tertile had over two-fold increased risk mortality (Hazard Ratio (HR) = 2.17; 95% CI: 1.27–3.71) when compared to the highest PIR tertile. Additionally, we found that PIR was as strong a predictor of mortality in cancer survivors as CVD. In patients with no CVD, the lowest PIR tertile continued to have almost a two-fold increased risk of mortality (HR = 1.72; 95% CI: 1.69–4.35) when compared to a reference of the highest PIR tertile.ConclusionsIn this large national study of cancer survivors, low PIR is associated with a higher prevalence of CVD. Low PIR is also associated with an increased risk of mortality in cancer survivors, showing a comparable impact to that of pre-existing and post-acquired CVD. Urgent public health resources are needed to further study and improve screening and access to care in this high-risk population.