bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Sequential One‐Pot Synthesis of Benzoxazoles from Aryl Bromides: Successive Palladium‐ and Copper‐Catalyzed Reactions.
Authors: Wu Xiao‐Feng , Neumann Helfried , Neumann Stephan , Beller Matthias 
Published: September 2013

AbstractThe Pd‐catalyzed aminocarbonylation of aryl bromides causes formation of intermediate amides.
ChemInform Abstract: Capture of 3‐Amino‐4‐oxycyanofurazan and Characterization of Isoxazole Product.
Authors: Luo Yifen , Wang Bozhou , Zhang Guofang , Zhou Yanshui , Lian Peng 
Published: September 2013

AbstractNitrile oxide (II) is assumed to be the reactive intermediate in the formation of (III) by dimerization or in the reaction with alkynes (IV) to give (V).
ChemInform Abstract: A Facile Synthesis of (5‐Hydroxy‐4‐oxo‐4H‐pyran‐2‐yl)methyl Carboxylates and Their Antiviral Activity Against Hepatitis C Virus.
Authors: Shimo Tetsuro , Taketsugu Yuki , Goto Takuya , Toyama Masaaki , Yoshimura Kohji , Baba Masanori 
Published: September 2013

AbstractTwelve oxopyranyl‐based compounds like (I) are synthesized in three steps from kojic acid in relatively good yields and investigated for their cytotoxicity and anti‐HCV activity in subgenomic HCV replicon cells.
ChemInform Abstract: A New Application of Mohr′s Salt as a Cheap and Powerful Catalyst for Synthesis of Novel Pyranocoumarins
Authors: Karami Bahador , Khodabakhshi Saeed , Eskandari Khalil 
Published: September 2013

Abstractvia three‐component reaction of 4‐hydroxycoumarin, aromatic aldehydes, and malononitriles
ChemInform Abstract: An Environmentally Benign Synthesis of Octahydro‐2H‐chromen‐4‐ols via Modified Montmorillonite K10 Catalyzed Prins Cyclization Reaction.
Authors: Baishya Gakul , Sarmah Barnali , Hazarika Nabajyoti 
Published: September 2013

AbstractMontmorillonite K10 treated with HCl is employed as reusable solid acid for the reaction of (‐)‐isopulegol (I) with aldehydes and cyclohexanone.
ChemInform Abstract: Synthesis, Characterization, and Herbicidal Activities of New 1,3,4‐Oxadiazoles, 1,3,4‐Thiadiazoles, and 1,2,4‐Triazoles Derivatives Bearing (R)‐5‐Chloro‐3‐fluoro‐2‐phenoxypyridine.
Authors: Kalhor Mehdi , Dadras Akbar 
Published: September 2013

AbstractAmong a variety of the title heterocycles, compounds (VII) and (XVIII) show potent herbicidal activity against gramineous weeds.
ChemInform Abstract: A Novel, Two‐Step Synthesis of 4‐Pyridone‐3‐carboxamides from 2‐Cyano‐4‐pyrones.
Authors: Obydennov Dmitrii L. , Sidorova Ekaterina S. , Usachev Boris I. , Sosnovskikh Vyacheslav Ya. 
Published: September 2013

AbstractThe approach to the biologically important pyridones includes formation of 5‐amino‐3‐oxopent‐4‐enamide intermediates.
ChemInform Abstract: Glycerol/Hypophosphorous Acid: An Efficient System Solvent‐Reducing Agent for the synthesis of 2‐Organylselanyl Pyridines.
Authors: Thurow Samuel , Webber Rodrigo , Perin Gelson , Lenardao Eder J. , Alves Diego 
Published: September 2013

AbstractThe reagent system is employed for the in situ generation of organylselenols which react further with 2‐chloropyridines.
ChemInform Abstract: An Efficient Coupling of N‐Tosylhydrazones with 2‐Halopyridines: Synthesis of 2‐α‐Styrylpyridines Endowed with Antitumor Activity.
Authors: Lawson Marie , Hamze Abdallah , Peyrat Jean‐Francois , Bignon Jerome , Dubois Joelle , Brion Jean‐Daniel , Alami Mouad 
Published: September 2013

AbstractAmong the newly synthesized compounds, derivative (IV) exhibits excellent antiproliferative and antimitotic activities comparable to that of the reference compound.
ChemInform Abstract: Efficient Synthesis of 2‐Pyridylenynes and Application in Cobalt‐Catalyzed Benzannulation Reactions.
Authors: Roese Philipp , Puenner Florian , Hilt Gerhard , Harms Klaus 
Published: September 2013

AbstractA one‐pot procedure is developed for the synthesis of the title compounds starting from pyridines bearing an ortho‐bromo or an ortho‐iodo substituent.
ChemInform Abstract: Substituted 4‐Oxo‐1,2,3,4‐tetrahydroquinoline‐3‐carboxylic Esters by a Tandem Imine Addition‐SNAr Reaction.
Authors: Bunce Richard A. , Schammerhorn James E. , Sigle Jessica 
Published: September 2013

AbstractThe title reaction yielding products of type (IV), (VII), or (X) is studied.
ChemInform Abstract: Proline Catalyzed Sequential α‐Aminooxylation or ‐Amination/Reductive Cyclization of o‐Nitrohydrocinnamaldehydes: A High Yield Synthesis of Chiral 3‐Substituted Tetrahydroquinolines.
Authors: Rawat Varun , Kumar B. Senthil , Sudalai Arumugam 
Published: September 2013

AbstractThe title reaction is efficiently used in the synthesis of compound (VIII), a key intermediate for the preparation of (‐)‐sumanirole (IX) and the known bioactive molecule (S)‐903 (XI).
ChemInform Abstract: Synthesis of Some New Heterocycles Derived from Ethyl 7‐Amino‐3‐ (3‐methyl‐5‐oxo‐1‐phenyl‐2‐pyrazolin‐4‐yl)‐5‐aryl‐5H‐thiazolo [3,2‐a]pyrimidine‐6‐carboxylate of Biological Importance.
Authors: Youssef Mohamed Salah K. , Abbady Mohamed S. , Ahmed Ragaa A. , Omar Ahmed A. 
Published: September 2013

AbstractA variety of new heterocycles containing both pyrazolone, thiazole, and fused pyrimidine moieties are synthesized starting from aminocarboxylate (I).
ChemInform Abstract: Synthesis of 2‐Amino 3‐Substituted Quinazolin‐4(3H)‐one Derivatives via Iodine‐Mediated Guanidinylation of Pbf‐Activated Thiourea.
Authors: Li Jizhen , Mi Yuhua , He Jianghua , Luo Xuyang , Fan Erkang 
Published: September 2013

AbstractTitle compounds are prepared using the Pbf‐activated thiourea moiety as guanidinylating reagent in the ring closure reaction step.
ChemInform Abstract: A Simple Access in One Step to Some New Substituted Pyrazolo‐ and [1,2,4]Triazolo‐[1,5‐a]pyrimidines.
Authors: Balti Monaem , Dridi Khaireddine , El Efrit Mohamed Lotfi 
Published: September 2013

AbstractA simple and general method for the preparation of pyrazolopyrimidines (III) and triazolopyrimidines (V) from the corresponding ketene dithioketals (I) and (IV), resp., and β‐cyanohydrazines (II) is presented.
ChemInform Abstract: Synthesis of Valganciclovir Hydrochloride Congeners.
Authors: Babu K. Srihari , Rao M. Raghavendar , Goverdhan G. , Srinivas P. , Reddy P. Pratap , Venkateswarlu G. , Anand R. Vijaya 
Published: September 2013

AbstractSome of the critical impurities (I) of valganciclovir hydrochloride are synthesized.
ChemInform Abstract: Design, Synthesis and Antiviral Activity of 2‐(3‐Amino‐4‐piperazinylphenyl)chromone Derivatives.
Authors: Kim Mi Kyoung , Yoon Hyunyun , Barnard Dale Lynn , Chong Youhoon 
Published: September 2013

AbstractNew chromone derivative (VII) shows antiviral activity against hepatitis C virus.
ChemInform Abstract: Catalyst‐Free Protocol for the Synthesis of Quinoxalines and Pyrazines in PEG.
Authors: Huang Tie‐Qiang , Qu Wen‐Yan , Ding Jin‐Chang , Liu Miao‐Chang , Wu Hua‐Yue , Chen Jiu‐Xi 
Published: September 2013

AbstractCompared to previously reported methodologies, the present, environmentally benign method features a simple workup, a wide range of substance scope and no need of any catalysts.
ChemInform Abstract: Highly Selective Bis(imino)pyridine Iron‐Catalyzed Alkene Hydroboration.
Authors: Obligacion Jennifer V. , Chirik Paul J. 
Published: September 2013

AbstractBis(imino)pyridine iron dinitrogen complexes are shown to promote the anti‐Markovnikov catalytic hydroboration of terminal, internal, and geminal alkenes with high activity and selectivity.
ChemInform Abstract: Mn(OAc)3‐Mediated Selective Free Radical Phosphonylation of Pyridinones and Pyrimidinones.
Authors: Sun Wan‐Bin , Ji Yun‐Fei , Pan Xiang‐Qiang , Zhou Shao‐Fang , Zou Jian‐Ping , Zhang Wei , Asekun Olayinkataiwo 
Published: September 2013

AbstractPhosporyl radicals are generated from the phosphite by oxidation with manganese(III) acetate.
ChemInform Abstract: Voulkensin C—E, New 11‐Oxocassane‐Type Diterpenoids and a Steroid Glycoside from Caesalpinia volkensii Stem Bark and Their Antiplasmodial Activities.
Authors: Ochieng Charles O. , Manguro Lawrence A. O. , Owuor Philip O. , Akala Hosea 
Published: September 2013

AbstractThree new cassane diterpenes, voulkensin C (Ia), D (Ib), and E (II), and a new steroidal‐stigmasterol glycoside (III) are isolated together with seven known compounds.
ChemInform Abstract: A Straightforward Access to Guaiazulene Derivatives Using Palladium‐Catalyzed sp2 or sp3 C—H Bond Functionalization.
Authors: Zhao Liqin , Bruneau Christian , Doucet Henri 
Published: September 2013

AbstractA novel Pd‐catalyzed arylation of guaiazulenes (I) with aryl bromides (II) is reported.
ChemInform Abstract: Studies on Novel Synthetic Methodologies. Part 184. Synthesis and Biological Activity of a Novel Pentacyclic Heterocycle.
Authors: Das Biswanath , Satyakumar Avula , Ravikanth Bommena , Rao Bommena Vittal , Raju Tuniki Venugopal , Siddhardha Busi , Murty Upadyayula Suryanaryana 
Published: September 2013

AbstractThe intramolecular cycloaddition of O‐allyloxy furanaldoxime (II) derived from D‐glucose to furanopyran‐2‐isoxazoline (III) and its diastereoselective reductive cleavage to the corresponding cis‐1,3‐amino alcohol (V) are the crucial conversions for the synthesis of the title compound (IX).
ChemInform Abstract: Highly Stereoselective Directed Reactions and an Efficient Synthesis of Azafuranoses from a Chiral Aziridine.
Authors: Lee Hogyu , Kim Jun Hee , Lee Won Koo , Cho Jaeheung , Nam Wonwoo , Lee Jaedeok , Ha Hyun‐Joon 
Published: September 2013

AbstractThe natural product (VII) and its C(3)‐epimer are synthesized from commercially available enantiopure aziridine (I) by highly stereoselective transformations in 61% overall yield.
ChemInform Abstract: Cleavage of 4,6‐O‐Benzylidene Acetal Using Sodium Hydrogen Sulfate Monohydrate.
Authors: Michigami Kyosuke , Terauchi Manami , Hayashi Masahiko 
Published: September 2013

AbstractThe deprotection is highly efficient in methanolic solvents with a good tolerance for typical O‐protecting groups.
ChemInform Abstract: Enantioselective Functionalization of Terminal Alkynes by Gold Catalysis
Authors: Mourad Asmaa Kamal , Czekelius Constantin 
Published: September 2013

AbstractReview: recent progress in the application of gold complexes with optically active ligands or counteranions for activation of alkynes towards nucleophiles, including the recently reported desymmetrization of terminal diynes; 70 refs.
ChemInform Abstract: A Review of Enzymes and Microbes for Lignocellulosic Biorefinery and the Possibility of Their Application to Consolidated Bioprocessing Technology
Authors: Hasunuma Tomohisa , Okazaki Fumiyoshi , Okai Naoko , Hara Kiyotaka Y. , Ishii Jun , Kondo Akihiko 
Published: September 2013

AbstractReview: 74 refs.
Usage of Ultrasound and Classification Methods for Continuous Detection of Dairy Fouling
Authors: Wallhäußer Eva , Sprunk Matthias , Sayed Ahmed , Nöbel Stefan , Hussein Mohamed A. , Hinrichs Jörg , Becker Thomas 
Published: September 2013

AbstractFouling ist ein schwerwiegendes Problem in der Lebensmittel‐ und insbesondere der Milchindustrie, da es zu einer verminderten Produktqualität und erhöhten Kosten führt. Es wird eine Methode vorgestellt, mit der Milchfouling über eine Kombination von Ultraschallmessungen und Mustererkennungsmethoden verfolgt und der Reinigungsfortschritt beobachtet werden kann. In einem planaren Wärmetauscher wurde Fouling reproduzierbar erstellt und mit einem Cleaning‐in‐Place‐Zyklus abgereinigt. Dabei wurden ultraschallbasierte Messungen durchgeführt, um den Reinigungsfortschritt zu bestimmen. Das System soll so die Reinigung eines verschmutzten Wärmetauschers online verfolgen und den Zustand „sauber”︁ anzeigen.
Metal‐Functionalized Silicene for Efficient Hydrogen Storage
Authors: Hussain Tanveer , Chakraborty Sudip , Ahuja Rajeev 
Published: September 2013

AbstractFirst‐principles calculations based on density functional theory are used to investigate the electronic structure along with the stability, bonding mechanism, band gap, and charge transfer of metal‐functionalized silicene to envisage its hydrogen‐storage capacity. Various metal atoms including Li, Na, K, Be, Mg, and Ca are doped into the most stable configuration of silicene. The corresponding binding energies and charge‐transfer mechanisms are discussed from the perspective of hydrogen‐storage compatibility. The Li and Na metal dopants are found to be ideally suitable, not only for strong metal‐to‐substrate binding and uniform distribution over the substrate, but also for the high‐capacity storage of hydrogen. The stabilities of both Li‐ and Na‐functionalized silicene are also confirmed through molecular dynamics simulations. It is found that both of the alkali metals, Li+and Na+, can adsorb five hydrogen molecules, attaining reasonably high storage capacities of 7.75 and 6.9 wt %, respectively, with average adsorption energies within the range suitable for practical hydrogen‐storage applications.
Scarcity of Rare Earth Elements
Authors: de Boer M. A. , Lammertsma K. 
Published: September 2013

AbstractRare earth elements (REEs) are important for green and a large variety of high‐tech technologies and are, therefore, in high demand. As a result, supply with REEs is likely to be disrupted (the degree of depends on the REE) in the near future. The 17 REEs are divided into heavy and light REEs. Other critical elements besides REEs, identified by the European Commission, are also becoming less easily available. Although there is no deficiency in the earth’s crust of rare earth oxides, the economic accessibility is limited. The increased demand for REEs, the decreasing export from China, and geopolitical concerns on availability contributed to the (re)opening of mines in Australia and the USA and other mines are slow to follow. As a result, short supply of particularly terbium, dysprosium, praseodymium, and neodymium is expected to be problematic for at least the short term, also because they cannot be substituted. Recycling REEs from electronic waste would be a solution, but so far there are hardly any established REE recycling methods. Decreasing the dependency on REEs, for example, by identifying possible replacements or increasing their efficient use, represents another possibility.
Chemo‐ and Regioselective Homogeneous Rhodium‐Catalyzed Hydroamidomethylation of Terminal Alkenes to N‐Alkylamides
Authors: Raoufmoghaddam Saeed , Drent Eite , Bouwman Elisabeth 
Published: September 2013

AbstractA rhodium/xantphos homogeneous catalyst system has been developed for direct chemo‐ and regioselective mono‐N‐alkylation of primary amides with 1‐alkenes and syngas through catalytic hydroamidomethylation with 1‐pentene and acetamide as model substrates. For appropriate catalyst performance, it appears to be essential that catalytic amounts of a strong acid promoter, such as p‐toluenesulfonic acid (HOTs), as well as larger amounts of a weakly acidic protic promoter, particularly hexafluoroisopropyl alcohol (HORF) are applied. Apart from the product N‐1‐hexylacetamide, the isomeric unsaturated intermediates, hexanol and higher mass byproducts, as well as the corresponding isomeric branched products, can be formed. Under optimized conditions, almost full alkene conversion can be achieved with more than 80 % selectivity to the product N‐1‐hexylamide. Interestingly, in the presence of a relatively high concentration of HORF, the same catalyst system shows a remarkably high selectivity for the formation of hexanol from 1‐pentene with syngas, thus presenting a unique example of a selective rhodium‐catalyzed hydroformylation–hydrogenation tandem reaction under mild conditions. Time‐dependent product formation during hydroamidomethylation batch experiments provides evidence for aldehyde and unsaturated intermediates; this clearly indicates the three‐step hydroformylation/condensation/hydrogenation reaction sequence that takes place in hydroamidomethylation. One likely role of the weakly acidic protic promoter, HORF, in combination with the strong acid HOTs, is to establish a dual‐functionality rhodium catalyst system comprised of a neutral rhodium(I) hydroformylation catalyst species and a cationic rhodium(III) complex capable of selectively reducing the imide and/or ene–amide intermediates that are in a dynamic, acid‐catalyzed condensation equilibrium with the aldehyde and amide in a syngas environment.
Fully automated analysis of chemically induced γH2AX foci in human peripheral blood mononuclear cells by indirect immunofluorescence
Authors: Willitzki Annika , Lorenz Sebastian , Hiemann Rico , Guttek Karina , Goihl Alexander , Hartig Roland , Conrad Karsten , Feist Eugen , Sack Ulrich , Schierack Peter , Heiserich Lisa , Eberle Caroline , Peters Vanessa , Roggenbuck Dirk , Reinhold Dirk 
Published: September 2013

AbstractAnalysis of phosphorylated histone protein H2AX (γH2AX) foci is currently the most sensitive method to detect DNA double‐strand breaks (DSB). This protein modification has the potential to become an individual biomarker of cellular stress, especially in the diagnosis and monitoring of neoplastic diseases. To make γH2AX foci analysis available as a routine screening method, different software approaches for automated immunofluorescence pattern evaluation have recently been developed. In this study, we used novel pattern recognition algorithms on the AKLIDES® platform to automatically analyze immunofluorescence images of γH2AX foci and compared the results with visual assessments. Dose‐ and time‐dependent γH2AX foci formation was investigated in human peripheral blood mononuclear cells (PBMCs) treated with the chemotherapeutic drug etoposide (ETP). Moreover, the AKLIDES system was used to analyze the impact of different immunomodulatory reagents on γH2AX foci formation in PBMCs. Apart from γH2AX foci counting the use of novel pattern recognition algorithms allowed the measurement of their fluorescence intensity and size, as well as the analysis of overlapping γH2AX foci. The comparison of automated and manual foci quantification showed overall a good correlation. After ETP exposure, a clear dose‐dependent increase of γH2AX foci formation was evident using the AKLIDES as well as Western blot analysis. Kinetic experiments on PBMCs incubated with 5 μM ETP demonstrated a peak in γH2AX foci formation after 4 to 8 h, while a removal of ETP resulted in a strong reduction of γH2AX foci after 1 to 4 h. In summary, this study demonstrated that the AKLIDES system can be used as an efficient automatic screening tool for γH2AX foci analysis by providing new evaluation features and facilitating the identification of drugs which induce or modulate DNA damage. © 2013 International Society for Advancement of Cytometry
Transgenerational soil‐mediated differences between plants experienced or naïve to a grass invasion
Authors: Deck Anna , Muir Adrianna , Strauss Sharon 
Published: September 2013

AbstractInvasive species may undergo rapid change as they invade. Native species persisting in invaded areas may also experience rapid change over this short timescale relative to native populations in uninvaded areas. We investigated the response of the native Achillea millefolium to soil from Holcus lanatus‐invaded and uninvaded areas, and we sought to determine whether differential responses between A. millefolium from invaded (invader experienced) and uninvaded (invader naïve) areas were mediated by soil community changes. Plants grown from seed from experienced and naïve areas responded differently to invaded and uninvaded soil with respect to germination time, biomass, and height. Overall, experienced plants grew faster and taller than their naïve counterparts. Naïve native plants showed negative feedbacks with their home soil and positive feedbacks with invaded soil; experienced plants were less responsive to soil differences. Our results suggest that native plants naïve to invasion may be more sensitive to soil communities than experienced plants, consistent with recent studies. While differences between naïve and experienced plants are transgenerational, our design cannot differentiate between differences that are genetically based, plastic, or both. Regardless, our results highlight the importance of seed source and population history in restoration, emphasizing the restoration potential of experienced seed sources.
First Total Synthesis of Pinolide
Authors: Yadav Jhillu Singh , Avuluri Srilatha , Kattela Shiva Shankar , Das Saibal 
Published: September 2013

AbstractThe first total synthesis of pinolide, a nonsymmetrical ten‐membered macrocyclic, is described starting from readily available (–)‐tartaric and L‐ascorbic acid. The key synthetic steps include Barbier allylation, Yamaguchi esterification and ring‐closing metathesis (RCM) reactions. The synthetic strategy has been successful for the construction of the ten‐membered core skeleton. A facile and convergent approach enabled the incorporation of all the four stereogenic centers present in the molecule.
The Application of Nafion Metal Catalyst Free Carbon Nanotube Modified Gold Electrode: Voltammetric Zinc Detection in Serum
Authors: Yue Wei , Bange Adam , L. Riehl Bill , M. Johnson Jay , Papautsky Ian , R. Heineman William 
Published: September 2013

AbstractMetal catalyst free carbon nanotube (MCFCNT) whiskers were first used as an electrode modification material on a gold electrode surface for zinc voltammetric measurements. A composite film of Nafion and MCFCNT whiskers was applied to a gold electrode surface to form a mechanically stable sensor. The sensor was then used for zinc detection in both acetate buffer solution and extracted bovine serum solution. A limit of detection of 53 nM was achieved for a 120 s deposition time. The zinc in bovine serum was extracted via a double extraction procedure using dithizone in chloroform as a zinc chelating ligand. The modified electrode was found to be both reliable and sensitive for zinc measurements in both matrices.
A Non‐Enzymatic Hydrogen Peroxide Sensor Based on Ag/MnOOH Nanocomposites
Authors: Bai Wushuang , Zheng Jianbin , Sheng Qinglin 
Published: September 2013

AbstractA novel non‐enzymatic sensor based on Ag/MnOOH nanocomposites was developed for the detection of hydrogen peroxide (H2O2). The H2O2 sensor was fabricated by immobilizing Ag/MnOOH nanocomposites on a glassy carbon electrode (GCE). The morphology and composition of the sensor surface were characterized using scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, transmission electron microscopy and X‐ray diffraction spectroscopy. The electrochemical investigation of the sensor indicates that it possesses an excellent electrocatalytic property for H2O2, and could detect H2O2 in a linear range from 5.0 µM to 12.8 mM with a detection limit of 1.5 µM at a signal‐to‐noise ratio of 3, a response time of 2 s and a sensitivity of 32.57 µA mM−1 cm−2. Additionally, the sensor exhibits good anti‐interference. The good analytical performance, low cost and straightforward preparation method made this novel electrode material promising for the development of effective non‐enzymatic H2O2 sensor.