bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obtaining a mouse model of streptozotocininduced type 1 diabetes mellitus
Authors: Skaletskaya G. N. , Skaletskiy N. N. , Bubentsova G. N. , Kirsanova L. A. , Basok Yu. B. , Sevastianov V. I. 
Published: July 2024

Objective: to obtain a stable mouse model of type 1 diabetes mellitus (T1DM) using streptozotocin (STZ), which has a toxic effect on pancreatic beta cells.Materials and methods. Experiments were performed on 30 white non-diabetic male mice of the SHK colony, which were injected intraperitoneally with STZ at a dose of 200 mg/ kg by two methods: 15 animals (group 1) once and 15 animals (group 2) intermittently – 5 consecutive days at 40 mg/kg per day.Results. In group 1, one mouse died after 2 days due to hypoglycemic coma, 4 mice developed hyperosmolar hyperglycemia (>33.3 mmol/l), 3 mice had spontaneous remission of diabetes, and 7 mice had stabilized hyperglycemia at levels close to 20 mmol/l. In group 2, only one mouse showed spontaneous remission of diabetes, while the remaining 14 animals showed stable diabetes with average hyperglycemia levels moderately above 20 mmol/L until the end of the 4-week follow-up. A histological study of the pancreas of these animals confirmed the destructive effect of STZ on islets in the form of mass death of insulin-producing β-cells.Conclusion. Split-dose intraperitoneal injection of STZ provides a stable experimental T1DM in 93% of laboratory mice.
Hypothermic oxygenated perfusion in liver transplantation from expanded criteria donors
Authors: Shabunin A. V. , Loran O. B. , Pushkar D. Yu. , Veliev E. I. , Minina M. G. , Drozdov P. A. , Astapovich S. A. , Lidzhieva E. A. 
Published: July 2024

Objective: to improve the outcomes of liver transplantation (LTx) from expanded criteria donors (ECDs) through hypothermic oxygenated machine perfusion (HOPE).Material and methods. The study included 63 cases of LTx from suboptimal brain-dead donors. Group I (control) consisted of 34 persons in which liver transplant was preserved only by static cold storage (SCS), while group II (main) comprised 29 cases where ex situ HOPE was used after static preservation. We evaluated the efficacy and safety of the latter in a comparative clinical study and by studying ultrastructural changes in the liver using electron microscopy.Results. No statistically significant differences between the groups in terms of baseline characteristics of donors, recipients and several perioperative parameters (p > 0.05) were obtained. Peak aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in the first week after transplantation were 1,052 (IQR: 712–1,842) U/L and 1,213 (IQR: 613–2,032) U/L in the HOPE group, and 1,943 (IQR: 1,294–5,214) U/L and 2,318 (IQR: 1,032–6,219) U/L in the SCS group (control). The levels were statistically significantly lower (p = 0.002 and p < 0.001, respectively). Median comprehensive complication index (CCI) in the main and control groups was 0 (IQR: 0–22.6) and 27.6 (IQR: 0–100) respectively. The differences were statistically significant (p = 0.001). Similarly, statistically significant differences were noted in terms of recipient time in the intensive care unit (ICU) and overall length of hospital stay (p = 0.042 and p = 0.028) – they were less in the HOPE group. Electron microscopy evaluation of the morphology of liver grafts revealed that hepatocytes sustained less injury during HOPE.Conclusion. Ex situ HOPE is a safe and effective way of preserving liver transplants. Its use in LTx from expanded criteria donors can lessen the severity of ischemia-reperfusion injury (IRI) in the organ and enable additional assessment of the suitability of an organ for transplantation.
Pregnancy after kidney transplantation: clinical features, complications and outcomes
Authors: Prokopenko E. I. , Nikolskaya I. G. , Vatazin A. V. , Burumkulova F. F. , Gubina D. V. 
Published: July 2024

Pregnancy after kidney transplantation (KT) has become more common, but the risk of complications and adverse obstetric outcomes in this group of women remains high.Objective: to study pregnancy complications and outcomes in kidney recipients and renal graft (RG) survival after childbirth.Material and methods. The study included 22 pregnancies in 20 women with RG (transplants performed in 2006–2020). The comparison group consisted of 20 healthy women who had 20 pregnancies. Frequency and nature of pregnancy complications, neonatal health indicators, and pregnancy outcomes were evaluated. Graft survival was compared in the main group and in a group of 102 women after KT who did not have pregnancies.Results. Compared with healthy women, RG recipients had a higher rate of preeclampsia (25% and 0%, p = 0.047), fetal growth restriction (30% and 0%, p = 0.020), gestational diabetes (40% and 5%, p = 0.020), asymptomatic bacteriuria (35% and 5%, p = 0.044), preterm birth (60% and 0%, p < 0.001), and cesarean section (70% and 10%, p < 0.001). Median gestational age and birth weight were significantly lower in women with RG: 36.0 [33.9; 37.4] vs. 38.9 [38.9; 39.6] weeks, p < 0.001, and 2405 [2023; 2958] vs. 3355 [3200; 3690] g, p < 0.001, respectively. The rate of favorable pregnancy outcomes after KT was 81.8%, or 90% when early pregnancy loss is excluded. Two children were found to have genetic diseases passed from the mother. Graft survival did not differ between RG recipients with and without pregnancy, p = 0.272.Conclusions. Pregnancy outcomes in patients with RG are generally favorable, pregnancy and childbirth do not affect graft survival. When planning pregnancy after KT, it is necessary to consider the risk of complications and the possibility of transmitting genetic disorders to offspring.
Hyperparathyroidism in kidney transplant candidates and postoperative parathyroid gland function in recipients
Authors: Vetchinnikova O. N. 
Published: July 2024

Objective: to evaluate the effects of secondary hyperparathyroidism (HPT) in kidney transplantation (KT) candidates on recipients’ parathyroid gland function in the first postoperative year.Materials and methods. The retrospective cohort study included 210 patients (103 women, 107 men, age 45 ± 9 years) with stage 5 chronic kidney disease (stage 5 CKD, including dialysis-dependent patients), who had undergone cadaveric KT. Biochemical screening before kidney transplantation and in the postoperative period at 3 and 12 months determined serum levels of parathyroid hormone (PTH), calcium, phosphorus, alkaline phosphatase activity, albumin and creatinine using standard methods. PTH levels of 130–595 pg/mL and ≤130 pg/mL were taken as the target level in the pre- and post-transplant periods, respectively.Results. Fifty-six KT candidates (group 1) had HPT and 154 (group 2) had the target PTH levels. PTH level was 897 (722; 1136) and 301 (229; 411) pg/mL, respectively, p < 0.001. PTH decreased in all recipients at 3 months after KT: by 595 (420; 812) in group 1 and 148 (77; 230) pg/ mL in group 2, p < 0.001, to 254 (180; 455) and 150 (118; 212) pg/mL, respectively, p < 0.001; the target level was detected in 10.7% and 42.2% of recipients, respectively, p < 0.001. At 12 months, blood PTH was 171 (94; 239) pg/mL in group 1 and 112 (90; 135) pg/mL in group 2, p = 0.004; target level was found in 48.2% and 73.4% of recipients, respectively, p < 0.001. Kidney graft function was identical in both recipient groups: acute tubular necrosis in 41.1% and 54.5%; at 3 months, median glomerular filtration rates (GFR) of 60 and 65 mL/min (n.d.); at 12 months, 56 and 54 mL/min (n.d.). Post-transplant PTH levels correlated directly with preoperative levels in both groups and inversely with renal graft function in group 2 recipients.Conclusion. HPT in kidney transplant candidates is a major, graft function-independent predictor of excess PTH secretion in recipients, increasing the risk of persistent HPT 1.9-fold, one year after KT.
Correlation between Job Demands, Work Meaningfulness, Job Stress, and Turnover Intention: Empirical Study in Public Sector Organizations
Authors: Yulabi Ruchan , Anggara Widi Galih , Istiqomah Iis 
Published: July 2024

This study aimed to test the relationship between job demand, work meaningfulness, and turnover intention with job stress as a mediating variable. A population of 1310 officers from a government unit were asked to complete questionnaires (which consisted of 32 questions adapted from previous research) employing a cross-sectional study approach. The final sample consisted of 383 responses, and regression analysis with Macro PROCESS was used to test the hypotheses. The findings indicate that job stress was positively correlated with job demands, but negatively correlated with work meaningfulness. Further, this study found that job stress positively correlated with turnover intention and was a mediating variable in the relationship between job demand, work meaningfulness, and turnover intention. This study implies that to lower turnover intention, organizations may decrease job demand and stress levels and improve work meaningfulness.
The Relationship Between Financial Wellness and Job Performance in Employees of PDAM Tugu Tirta in Malang City
Authors: Mustafa Mifta Ihza Zahwa , Chusniyah Tutut , Bimantoro Demanda 
Published: July 2024

Job performance is a crucial criterion related to organizational outcomes and success. One of the factors that influence job performance is individual financial wellness. This research examines the relationship between financial wellness and job performance among employees of PDAM Tugu Tirta in Malang City. This research utilized a quantitative, non-experimental correlational method. The sample consisted of 100 employees of PDAM Tugu Tirta in Malang City, selected using an accidental sampling technique. The instruments employed were the Personal Financial Wellness Questionnaire and the Individual Job Performance Questionnaire. The data analysis involved the use of Pearson's product-moment correlation analysis. The analysis results indicate that financial wellness has a significant positive relationship with job performance (rxy equals .662; Sig. equals 0.00).
Cross-Cultural Aspects of Familie Theme in Learning German as a Foreign Language for Grade XI of Senior High School
Authors: Nastiti Hadijah , Rosyidah Rosyidah 
Published: July 2024

This research aims to describe the cross-cultural aspects of the Familie theme in learning German and its implementation in learning German for XI grade of Senior High School. This research method used literature review: German curriculum for high school, syllabus, lesson plans, German language textbooks for A1 level high school, books, research results, and articles related to the use of intercultural learning methods. Then, all research data are grouped in tabular form, summarized and narrated. The results showed that the cross-cultural aspects studied in learning German for XI gradecontained in Familie theme consisted of the sub-themes Familienaktivitäten, Familienstammbaum, Familienalbum, and Familienname. Cross-cultural aspects could be implemented in learning German in XI grade Senior High School with three methods, they are discussion method, the comparing and commenting method, and the Stationenlernen method. Among the three methods, comparing and commenting methods are recommended to be implemented in learning German in XI grade of Senior High School.
Industries culturelles hors des pôles créatifs en temps de pandémie : trois joueurs clés pour assurer la pérennité
Authors: Berube Julie , Pouliot Alexis 
Published: July 2024

Le printemps 2020 a été marqué par une pandémie sans précédent mettant en suspens les activités culturelles à travers le monde, incluant le Québec. Les salles de spectacles, les lieux d’exposition et de création ont dû fermer leurs portes. Face à ce cataclysme qui paralysa les industries culturelles, les artistes, les organismes culturels et les institutions publiques ont dû faire preuve d’inventivité afin d’assurer la pérennité de ces industries. Des fonds publics ont été affectés à ces industries et plusieurs initiatives ont vu le jour principalement dans les pôles créatifs comme Montréal au Québec. L’objectif de cette recherche est de comprendre comment les acteurs locaux des industries culturelles ont réussi à mettre en place des dispositifs permettant d’assurer la pérennité des industries culturelles hors des pôles créatifs. Afin de répondre à cet objectif, nous avons mené des groupes de discussion et des entrevues semi-dirigées avec des artistes, des travailleurs d’organismes culturels et des travailleurs municipaux. Les résultats s’articulent autour de trois thèmes. Premièrement, les problématiques principales touchant les industries culturelles hors des pôles créatifs sont présentées. Dans un deuxième temps, nous identifions les initiatives ayant été mises en place afin de faire face à ces problématiques. Finalement, nous présentons les embûches vécues entre les différents groupes (artistes, organismes culturels, institution municipale) et la manière dont ceux-ci ont pu collaborer afin de favoriser la pérennité des industries culturelles.
Application of Various Nutrition to the Growth and Production of Melon (Cucumis melo L.) Hydroponic DRFT (Dynamic Root Floating Technique)
Authors: Chairudin Chairudin , Fitria Rika , Harahap Evi Julianita 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian nutrisi terhadap pertumbuhan dan produksi tanaman melon secara hidroponik DRFT (Dynamic Root Floating Technique). Rancangan percobaan yang digunakan dalam penelitian ini adalah rancangan acak kelompok (RAK) dengan pola non faktorial dengan 3 perlakuan dengan 3 ulangan. Faktor yang diteliti adalah nutrisi yang terdiri dari 3 taraf yaitu N1 (AB Mix) = 5 mL/l, N2 (Goodplant) = 5 mL/l, dan N3 (Hydro-J) = 5 mL/l. Parameter yang diamati adalah tinggi tanaman (cm), jumlah daun (helai), diameter batang (mm), bobot buah (kg), dan diameter buah (mm). Hasil penelitian menunjukkan bahwa perlakuan N3 (Hydro-J) berbeda nyata terhadap parameter tinggi tanaman dan jumlah daun pada umur 21 hari setelah tanam dan 28 hari setelah tanam dibandingkan dengan N2 (Goodplant), namun tidak berbeda nyata dengan N1 (AB mix).

Keywords: Nutrisi AB Mix, Goodplant, Hydro-J
The Efektivitas Jet Aerator dalam Pengolahan Limbah Cair Penyamakan Kulit
Authors: Vera Vincentia Veni , Lastriyanto Anang , Anugroho Fajri , Sulianto Adi , Nugroho Wahyunanto Agung 
Published: July 2024

Finished leather, a primary material for making shoes, bags, and wallets, is processed through tanning to remove veins and feathers. Liquid waste contains a high demand for chemical oxygen (COD), chloride, chromium, and sulfide that can affect river water quality if not treated further. This research was conducted at PT X in Malang City, where liquid waste treatment using an aerator is considered less effective. The tool used in this study is a jet aerator to increase the spread of oxygen in the aeration process. The study aimed to assess changes in the characteristics of tanning liquid waste (pH, temperature, total suspended solids/TSS), and COD) and the effectiveness of using jet aerators in aeration methods in tanning liquid waste treatment. Aeration is carried out for three days. The treatment carried out is aerator + 15 L (A15), jet aerator + 15 L (JA15), and jet aerator + 20 L (JA20). The data were analyzed using Factorial Complete Randomized Design followed by the Smallest Significant Difference test. pH and temperature have met quality standards, while TSS and COD have not. The results showed that the jet aerator +15 L (JA15) decreased maximum tanning liquid waste characteristics on day 1. In contrast, aerator +15 L (A15) and jet aerator +20 L (JA20) decreased maximum waste characteristics on day 2. The jet aerator+15 L (JA15) treatment provides the highest effectiveness value compared to other treatments. COD decreased 49.2%, and TSS decreased 49.7%.

Keywords: jet aerator, leather tanning liquid waste
Dinamika dan Daya Saing Sektor Pertanian di Kabupaten Padang Pariaman, Sumatera Barat
Authors: Mahendra Zori , Fitriana Widya , Yuerlita Yuerlita 
Published: July 2024

Regional economic development is closely related to the role of the agricultural sector. In addition to food production, agriculture also contributes to the absorption of labor. During the COVID-19 pandemic, regional economic growth in Indonesia tended to decline, as well as in Padang Pariaman. Padang Pariaman will have a negative growth rate of 10.46% in 2020, the lowest compared to the average GDP growth rate of the other region in West Sumatra. This study aims to determine the dynamics and competitiveness of the agricultural sector compared to the other sectors. The research was conducted in a quantitative and descriptive manner using time series data for the period 2016–2020 from BPS. Data analysis using Klassen typology and shift share analysis. The results showed that the agricultural sector has an average share of 21.37% of the GDP of Padang Pariaman. Based on Klassen's typology analysis, the agriculture sector was included in the potential sector category in 2017–2019 but shifted to the developed sector category in 2020. Despite experiencing slow growth, the results of shift share analysis show that the agricultural sector in Padang Pariaman is still competitive. Increasing the competitiveness of the agricultural sector can be pursued by expanding sector linkages with the other economic sectors and increasing diversification of economics activities in agricultural sector

Keywords: agricultural sector; shift share analysis; tipology klassen
Особливості спортивної журналістики в Україні: історія становлення, проблеми та основні тенденції розвитку
Authors: Локшин П. С. , Грисюк В. П. , Єфімова М. П. 
Published: July 2024

У контексті оновлених даних розглянуто історію та сучасні тенденції української спортивної журналістики, а також проаналізовано тенденції її розвитку на найближчі роки. Спортивна журналістика має специфічні засоби, технології, форми, жанри та інструменти, а фахівці, які професійно займаються цим напрямом у журналістиці, опановують осяжні масиви тематичної інформації. Істотне значення при цьому має і додаткова профільна освіта, зокрема прослуховування публічних лекцій, майстер-класів, курсів підвищення кваліфікації при університетах та в рамках стажувань в інших організаціях та компаніях. Прийоми створення та технології поширення спортивного контенту є важливою та актуальною темою для детального вивчення.
Феномен чуток в епоху постправди
Authors: Смола Л. Є. 
Published: July 2024

У статті здійснено спробу дослідити феномен чуток у ХХІ ст. Проаналізовано доробок західних науковців, які окреслюють контекст, зміст та особливості чуток у світі постправди. Проаналізовано сучасні дослідження феномену чуток в українській та закордонній науковій думці. Виокремлено особливості інформаційного простору, де виникають чутки.
Здійснено спробу продемонструвати трансформацію феномену чуток та особливості підходів до них із появою інтернету і соціальних медіа. У пра­ці окреслено особливості «постправдового» дискурсу та дискурсу популізму, які необхідно враховувати в дослідженні феномену чуток.
Медіаобраз сім’ї в сучасному українському телевізійному дискурсі
Authors: Супрун В. М. , Супрун Л. В. 
Published: July 2024

Сучасна парадигма інформаційного суспільства накладає свій відбиток на особистісний простір людини, до якого належить територія сімейного життя, моделюючи його медіаобраз відповідно до рейтингової кон’юнктури медіаконтенту. Телевізійний дискурс характеризується доступним інструментом для модуляції суспільної свідомості, тому здатний впливати на ставлення до інституту сім’ї.
Вплив на масову аудиторію телевізійного контенту інспірує своє розуміння медіаобразу сім’ї, що часто не корелюється з традиційним баченням родини в українському суспільстві.
Дослідження було проведеноза допомогою як загальнонаукових методів наукового пошуку – аналізу й синтезу, так і сучасних конкретнонаукових методів соціальних комунікацій, зокрема описового, компаративного, соціально зорієнтованої інтерпретації, елементів концептуального та аксіологічного методологічних підходів.
Development of a Reference Installation for Metrological Support of the Delta Value Measurements of the Ratio of Carbon and Oxygen Isotopes in Exhaled Air
Authors: Chubchenko I. K. , Kolobova A. V. , Larosh A. V. , Afanasyev G. A. 
Published: July 2024

Breath tests in domestic and foreign medicine are recognized as an effective and safe way to identify pathogens in the gastrointestinal tract, in particular the Helicobacter Pylori bacteria. At the end of the 20th century, a urease breath test was introduced into clinical practice to diagnose diseases of the gastrointestinal tract; it was based on the use of urea labeled with a stable isotope 13C ( 13C-urease breath test). The essence was to measure the delta value of the ratio of carbon and oxygen isotopes in exhaled air.Over decades of clinical practice of using this test, a wealth of experience related to the diagnosis of diseases caused, including by the Helicobacter Pylori bacteria has been accumulated. A significant amount of knowledge has also been accumulated in terms of metrological support of the carbon and oxygen isotope delta in exhaled air.The article describes the procedure and results of developing a development of a measurement standard of carbon and oxygen isotope delta in exhaled air, implemented within the R&D a/c No. «Sistema-2020-М» at the D. I. Mendeleyev Institute for Metrology (VNIIM). The authors presented the theoretical study, test methodology, their sequence and results. The article also contains a report on the international comparisons CCQM-P204 “Isotope ratios of CO2 (δ13VPDB and δ18VPDB) in pure CO2” with the application of the measurement standard developed by VNIIM. The metrological characteristics of the measurement standard obtained during the comparisons correspond to the most accurate measurements of the ratio of carbon and oxygen isotopes, which guarantees the recognition of the measurement results at the international level. Considering the high demand for breath tests in medical practice and obvious prospects of this type of diagnostics, further research will be aimed at creating a State Primary Standard for the delta value unit of the ratio of isotopes of carbon, oxygen, hydrogen based on the created measurement standard and the development of certified reference materials of the ratio of isotopes of carbon, oxygen, hydrogen in liquid, solid, and gaseous media, including for the purpose of replacing foreign-made materials.