Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO)
Authors: Schmitz Kathryn H , Brown Justin C , Irwin Melinda L , Robien Kim , Scott Jessica M , Berger Nathan A , Caan Bette , Cercek Andrea , Crane Tracy E , Evans Scott R , Ligibel Jennifer A , Meyerhardt Jeffrey A , Agurs-Collins Tanya , Basen-Engquist Karen , Bea Jennifer W , Cai Sheng F , Cartmel Brenda , Chinchilli Vernon M , Demark-Wahnefried Wendy , Dieli-Conwright Christina M , DiPietro Loretta , Doerksen Shawna E , Edelstein Sharon L , Elena Joanne , Evans William , Ferrucci Leah M , Foldi Julia , Freylersythe Sarah , Furberg Helena , Jones Lee W , Levine Ross , Moskowitz Chaya S , Owusu Cynthia , Penedo Frank , Rabin Borsika A , Ratner Elena , Rosenzweig Margaret , Salz Talya , Sanft Tara , Schlumbrecht Matthew , Spielmann Guillaume , Thomson Cynthia A , Tjaden Ashley H , Weiser Martin R , Yang Shengping , Yu Anthony F , Perna Frank M ,   for the ENICTO Consortium, Caan Bette , Anderson Sydney , Bahia Harmenjit , Castillo Adrienne , Feliciano Elizabeth , Johnson Kristina , Ross Michelle , Weltzein Erin , Brown Justin C , Albarado Baylea , Compton Stephanie , Green Tamara , Nash Ryan , Nauta Phillip , Welch Meredith , Yang Shengping , Meyerhardt Jeffrey A , Dieli-Conwright Christina M , Nguyen Danny , Pena Amalia Perez , Spielmann Guillaume , Kim Youyoung , Evans William J , Bea Jennifer W , Blew Robert M , Crane Tracy E , Bhatti Atif , Clavon Reanna , Erlandsen Stefan Spee , Freylersythe Sarah , Hollander Kenna , Lopez-Pentecost Melissa , Penedo Frank J , Rolle LaShae , Rossi Paola , Schlumbrecht Matthew , Wheeler Madalyn , Irwin Melinda L , Cao Anlan , Cartmel Brenda , Ferrucci Leah M , Gottlieb Linda , Harrigan Maura , Li Fang-Yong , McGowan Courtney , Puklin Leah , Ratner Elena , Sanft Tara , Zupa Michelle , Berger Nathan A , Cerne Stephen , Mills Carissa , Conochan Sandy , Hundal Jasmin , Owusu Cynthia , Ligibel Jennifer A , Campbell Nancy , DiGuglielmo Kaedryn , Kemp Wendy , Maples-Campbell Christopher , Nguyen Truong , Oppenheim Jay , Tanasijevic Anna , Thomson Cynthia , Yung Angela , Basen-Engquist Karen , Loomba Preena , Chinchilli Vernon M , Schmitz Kathryn H , Binder Jenna , Doerksen Shawna E , Foldi Julia , Garrett Sara , Scalise Raymond , Sobolewski Michele , White Lacey , Scott Jessica M , Cercek Andrea , Cai Sheng F , Cao Stephanie , Furberg Helena , Harrison Jenna , Jones Lee W , Lee Catherine , Levine Ross , Michalski Meghan , Moskowitz Chaya S , Novo Robert , Rabazzi Julia , Stoeckel Kurtis , Salz Talya , Weiser Martin R , Yu Anthony F , Demark-Wahnefried Wendy , Robien Kim , Evans Scott R , DiPietro Loretta , Duong Bao , Edelstein Sharon L , Helmchen Lorens , Le Daisy , McCleary Caitlin , Tjaden Ashley H , Wopat Heather , Rabin Borsika A , Perna Frank M , Agurs-Collins Tanya , Czajkowski Susan M , Elena Joanne , Nebeling Linda C , Norton Wynne E 
Published: August 2024

Abstract
Chemotherapy treatment-related side effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity. The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium to address this knowledge gap. This article describes the mechanisms hypothesized to underpin intervention effects on clinically relevant treatment outcomes, briefly outlines each project’s distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the integrated common data elements used to pursue research questions collectively. In addition, the article includes a description of consortium-wide activities and broader research community opportunities for collaborative research. Findings from the ENICTO Consortium have the potential to accelerate a paradigm shift in oncology care such that patients with cancer could receive exercise and nutrition programming as the standard of care in tandem with chemotherapy to improve relative dose intensity for a curative outcome.