bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examples of lake disappearance as an effect of reclamation works in Poland
Authors: Choiński Adam , Ptak Mariusz , Strzelczak Agnieszka 
Published: March 2013

AbstractGlacial lakes undergo evolution with their disappearance as the last stage of it. Natural processes which determine the rate of lake shrinking occur rather slowly but they have been increasing their speed with the stronger human interference in the environment. The most drastic effect of anthropogenic pressure exerted on lake ecosystems is their complete disappearance caused by reclamation works. One can state that this process is a change of rapid character (a lake can disappear within a few years or several decades, in extreme cases even within one year). Drainage works are particularly unfavourable in areas with a shortage of water supplies, where rapid lake shallowing reduces water retention even more. A considerable part of Poland suffers from water supply deficiency. Therefore, draining of lakes should be considered as an adverse operation. This study discusses the examples of eleven lakes located in Poland and subjected to reclamation works. Analyses of those cases lead us to the conclusion that drainage aiming to broaden agricultural areas has not always been proper.
Dammed lakes – Present state of knowledge and research requirements
Authors: Marszelewski Włodzimierz , Kornaś Marika 
Published: March 2013

AbstractThe paper presents the current state of knowledge on dammed lakes in Poland and identifies the crucial research necessities in this area. The analysis of documents concerning dammed lakes and information obtained from institutions responsible for water management in Poland were the basis for a preliminary qualitative and quantitative assessment of dammed lakes located in north-west Poland. This allowed the identification of the necessary directions to be taken in the study of dammed lakes. In many cases, the indicated directions are innovative and have high potential for application.
Risk factors for gliomas. An extensive review
Authors: Florian I.S. , Ungureanu G. , Berce C. 
Published: March 2013

Abstract
Primary brain tumors consist are a heterogenic group of malignancies. Gliomas represent subtypes which include all tumors arising from glial cells. The risk factors for gliomas are until today unclear. The aim of this study was to summarize all possible connections between suspected risk factors and glial brain tumors.
First experience in intracranial aneurysm occlusion by balloon assisted coiling technique
Authors: Chiriac A. , Iliescu B. , Dobrin N. , Poeata I. 
Published: March 2013

Abstract
Particular anatomical situation like wideneck aneurysms or a large neck/fundus ratio, located on an arterial bifurcation or a small artery, are still a challenge for endovascular coil occlusion. These are due to the risk of coil migration or coil protrusion into the parent vessels. In our study we describe the balloon assisted coiling technique regarding the efficacy and safety of its practice and the problems that could appear.
Strain-rate estimates for crevasse formation at an alpine ice divide: Mount Hunter, Alaska
Authors: Campbell Seth , Roy Samuel , Kreutz Karl , Arcone Steven A. , Osterberg Erich C. , Koons Peter 
Published: March 2013

AbstractCrevasse initiation is linked to strain rates that range over three orders of magnitude (0.001 and 0.163 a-1) as a result of the temperature-dependent nonlinear rheological properties of ice and from water and debris inclusions. Here we discuss a small cold glacier that contains buried crevasses at and near an ice divide. Surface-conformable stratigraphy, the glacier’s small size, and cold temperatures argue for limited rheological variability at this site. Surface ice-flow velocities of (1.2-15.5) ± 0.472 m a- 1 imply classic saddle flow surrounding the ice divide. Numerical models that incorporate field-observed boundary conditions suggest extensional strain rates of 0.003-0.015 a- 1 , which fall within the published estimates required for crevasse initiation. The occurrence of one crevasse beginning at 50 m depth that appears to penetrate close to the bed suggests that it formed at depth. Field data and numerical models indicate that a higher interior stress at this crevasse location may be associated with steep convex bed topography; however, the dynamics that caused its formation are not entirely clear.
Être parent avec et sans l'autre. Les exigences paradoxales de notre société contemporaine
Authors: Janssen Christophe 
Published: March 2013

À partir de deux vignettes a priori sans rapport, l’auteur se propose de réfléchir aux effets des transformations sociales sur le rapport que les individus entretiennent avec la parentalité. Revendication d’autonomie, création et utilisation d’un réseau « coparental » autour de l’enfant ; il sera question de mesurer l’intérêt dans un cadre clinique de porter attention aux modalités de rencontre, ou de non-rencontre, entre la créativité des parents et leur environnement. L’auteur en arrivera à paraphraser D.W. Winnicott en proclamant qu’« un parent, ça n’existe pas ! ».
Signaling through Purinergic Receptors for ATP Induces Human Cutaneous Innate and Adaptive Th17 Responses: Implications in the Pathogenesis of Psoriasis
Authors: Killeen Meaghan E. , Ferris Laura , Kupetsky Erine A. , Falo Louis , Mathers Alicia R. 
Published: March 2013

AbstractHuman cutaneous dendritic cells (DCs) have the ability to prime and bias Th17 lymphocytes. However, the factors that stimulate cutaneous DCs to induce Th17 responses are not well known. Alarmins, such as ATP, likely play a pivotal role in the induction and maintenance of cutaneous immune responses by stimulating DC maturation, chemotaxis, and secretion of IL-1β and IL-6, Th17-biasing cytokines. In this study, using a well-established human skin model, we have demonstrated that signaling purinergic receptors, predominantly the P2X7 receptor (P2X7R), via an ATP analog initiate innate proinflammatory inflammation, DC17 differentiation, and the subsequent induction of Th17-biased immunity. Moreover, our results suggest a potential role for P2X7R signaling in the initiation of psoriasis pathogenesis, a Th17-dependent autoimmune disease. In support of this, we observed the increased presence of P2X7R in nonlesional and lesional psoriatic skin compared with normal healthy tissues. Interestingly, there was also a P2X7R variant that was highly expressed in lesional psoriatic skin compared with nonlesional psoriatic and normal healthy skin. Furthermore, we demonstrated that psoriatic responses could be initiated via P2X7R signaling in nonlesional skin following treatment with a P2X7R agonist. Mechanistic studies revealed a P2X7R-dependent mir-21 angiogenesis pathway that leads to the expression of vascular endothelial growth factor and IL-6 and that may be involved in the development of psoriatic lesions. In conclusion, we have established that purinergic signaling in the skin induces innate inflammation, leading to the differentiation of human Th17 responses, which have implications in the pathogenesis and potential treatment of psoriasis.
Antigen-Reactive T Cell Enrichment for Direct, High-Resolution Analysis of the Human Naive and Memory Th Cell Repertoire
Authors: Bacher Petra , Schink Christian , Teutschbein Janka , Kniemeyer Olaf , Assenmacher Mario , Brakhage Axel A. , Scheffold Alexander 
Published: March 2013

Abstract
Ag-specific CD4+ T cells orchestrating adaptive immune responses are crucial for the development of protective immunity, but also mediate immunopathologies. To date, technical limitations often prevented their direct analysis. In this study, we report a sensitive flow cytometric assay based on magnetic pre-enrichment of CD154+ T cells to visualize rare Ag-reactive naive and memory Th cells directly from human peripheral blood. The detection limit of ∼1 cell within 105–106 permitted the direct enumeration and characterization of auto-, tumor-, or neo-Ag–reactive T cells within the naive and even memory CD4+ T cell repertoire of healthy donors. Furthermore, the analysis of high target cell numbers after pre-enrichment of rare Ag-specific T cells from large blood samples dramatically improved the identification of small subpopulations. As exemplified in this work, the dissection of the Ag-specific memory responses into small cytokine-producing subsets revealed great heterogeneity between pathogens, but also pathogen-related microsignatures refining Th cell subset classification. The possibility to directly analyze CD4+ T cells reactive against basically any Ag of interest at high resolution within the naive and memory repertoire will open up new avenues to investigate CD4+ T cell–mediated immune reactions and their use for clinical diagnostics.
Monocyte ADAM17 Promotes Diapedesis during Transendothelial Migration: Identification of Steps and Substrates Targeted by Metalloproteinases
Authors: Tsubota Yoshiaki , Frey Jeremy M. , Tai Phillip W. L. , Welikson Robert E. , Raines Elaine W. 
Published: March 2013

Abstract
Despite expanded definition of the leukocyte adhesion cascade and mechanisms underlying individual steps, very little is known about regulatory mechanisms controlling sequential shifts between steps. We tested the hypothesis that metalloproteinases provide a mechanism to rapidly transition monocytes between different steps. Our study identifies diapedesis as a step targeted by metalloproteinase activity. Time-lapse video microscopy shows that the presence of a metalloproteinase inhibitor results in a doubling of the time required for human monocytes to complete diapedesis on unactivated or inflamed human endothelium, under both static and physiological-flow conditions. Thus, diapedesis is promoted by metalloproteinase activity. In contrast, neither adhesion of monocytes nor their locomotion over the endothelium is altered by metalloproteinase inhibition. We further demonstrate that metalloproteinase inhibition significantly elevates monocyte cell surface levels of integrins CD11b/CD18 (Mac-1), specifically during transendothelial migration. Interestingly, such alterations are not detected for other endothelial- and monocyte-adhesion molecules that are presumed metalloproteinase substrates. Two major transmembrane metalloproteinases, a disintegrin and metalloproteinase (ADAM)17 and ADAM10, are identified as enzymes that control constitutive cleavage of Mac-1. We further establish that knockdown of monocyte ADAM17, but not endothelial ADAM10 or ADAM17 or monocyte ADAM10, reproduces the diapedesis delay observed with metalloproteinase inhibition. Therefore, we conclude that monocyte ADAM17 facilitates the completion of transendothelial migration by accelerating the rate of diapedesis. We propose that the progression of diapedesis may be regulated by spatial and temporal cleavage of Mac-1, which is triggered upon interaction with endothelium.
Uma ilustre desconhecida: a formação docente para a educação profissional
Authors: Urbanetz Sandra Terezinha 
Published: March 2013

Este artigo discute a produção acadêmica sobre formação de professores para a educação profissional sob a perspectiva da formação de professores em geral, apontando a urgente necessidade do tema, posto que essa modalidade encontra-se como um permanente desafio social. A partir das publicações disponíveis no site da Capes (Coordenação de Aperfeiçoamento de Pessoal de Nível Superior) e da Anped (Associação Nacional de Pós-Graduação e Pesquisa em Educação), faz-se uma discussão sobre as publicações deformação docente. À luz da perspectiva materialista, observa-se a quase inexistência dessa temática em pesquisas e publicações, compreendendo-se que isso se dá a partir da indefinição de políticas de formação para esses docentes.
Labor Force Participation in Adults With Osteoarthritis or Joint Symptoms Typical of Osteoarthritis: Findings From a Canadian Longitudinal Study on Aging
Authors: Badley Elizabeth M. , Zahid Shatabdy , Wilfong Jessica M. , Perruccio Anthony V. 
Published: July 2024

ObjectiveThe purpose of the study is to examine the relationship between osteoarthritis (OA) and joint symptoms typical of OA and labor force participation.MethodsData are from the baseline questionnaire of the Canadian Longitudinal Study on Aging for respondents aged 45 to 74 years at baseline (n = 24,427). Individuals were categorized into one of five mutually exclusive arthritis status groups: diagnosed OA, diagnosed other type of arthritis, two to three symptomatic joint sites and no diagnosed arthritis, one symptomatic joint site and no diagnosed arthritis, and no arthritis and no joint symptoms. Age‐stratified robust log‐Poisson regression analysis was used to examine the association between arthritis status and labor force participation.ResultsOverall, 39% of the analytic sample reported being out of the labor force. Those with OA aged 45 to 54 and 55 to 64 years were significantly more likely to be out of the labor force than those with no arthritis or no joint symptoms, with prevalence ratios (PRs) of 1.34 (95% confidence interval [CI] 1.10–1.65) and 1.13 (95% CI 1.06–1.21), respectively, with similar results for those with two to three joint symptoms and no OA in the 45 to 54 years age group (PR 1.37 [95% CI 1.07–1.76]). There was no difference for those aged 65 to 74 years. Being an informal caregiver increased the likelihood of nonparticipation in the labor force for those aged 55 to 64 years (PR 1.09 [95% CI 1.04–1.15]).ConclusionOur results suggest that an exclusive reliance on an OA diagnosis to understand impact on labor force participation may miss a large segment of the middle‐aged population, which may have undiagnosed OA or be at greater risk of OA because of joint problems.
Exploring the Bidirectional Relationship Between Periodontitis and Rheumatoid Arthritis in a Large Danish Cohort
Authors: Raittio Eero , Nascimento Gustavo G. , Lopez Rodrigo , Baelum Vibeke 
Published: July 2024

ObjectiveWe investigated the bidirectional relationship between rheumatoid arthritis (RA) and periodontitis and their cross‐sectional association using national administrative health care data.MethodsThe sample included 3,308,903 individuals aged 20 to 79 years who resided in Denmark in 2000 and had remained free of RA and periodontitis in the previous 10 years. RA and periodontitis were defined using diagnosis and treatment codes. Marginal structural survival models were employed to estimate the effects of RA on periodontitis incidence and vice versa from 2000 to 2017. Using a cross‐sectional sample of 2,574,536 individuals from 2017, the association of periodontitis with RA was investigated using regression analyses and probabilistic quantitative bias analyses, simulating RA and periodontitis misclassification and unmeasured confounding of smoking.ResultsBetween 2000 and 2017, 20,348 individuals developed RA and 740,799 developed periodontitis. The estimated hazard ratio (HR) for the effect of periodontitis on incident RA was 1.05 (95% confidence interval [CI] 0.88–1.25), resulting in a restricted mean survival time difference of one day. The HR for the effect of RA on incident periodontitis was 0.84 (95% CI 0.80–0.88), corresponding to a restricted mean survival time difference of 151 days. Cross‐sectionally, the unadjusted prevalence ratio for the association was 1.15 (95% CI 1.11–1.19), whereas the estimate adjusted for measured and simulated confounding was practically null (0.99, 95% simulation interval 0.93–1.04).ConclusionThese findings challenge previously reported bidirectional relationships between periodontitis and RA, pointing to potential residual confounding as an important link and prompting reconsideration of the biologic plausibility and clinical significance of these associations.image
Interplay of Cooper Pairs and Zero‐Energy Quasiparticles in a Gapless Superconductor
Authors: Lee Jhinhwan , Park Hae‐Ryong , Kim Jun Sung , Yeom Han Woong 
Published: July 2024

AbstractThe interplay between Cooper pairs and Bogoliubov‐de Gennes (BdG) quasiparticles is a topic of considerable interest in the quantum properties of solids, but its important ingredient, the sufficient amount of low‐energy quasiparticles to interact with Cooper pairs remains elusive in conventional superconductors. Here a gapless superconductor with coupled paramagnetic atomic layers is used to generate a significant amount of zero‐energy quasiparticles that Anderson‐localize and bifurcate into regions of high and low zero‐energy quasiparticle density of states. The enriched zero‐energy quasiparticles induce puddled superconductivity and Josephson vortices. This discovery not only advances the understanding of the mutual interaction of Cooper pairs and BdG quasiparticles but also opens a new avenue for exploring and controlling exotic quantum phenomena where superconductivity, disorder, and spin degrees of freedom are entangled.
Giant Plasmonic Enhancement of Chiroptical Properties by Anisotropic Gold Nanocrystals Grown In Situ in a Chiral Polymer
Authors: Abraham Shema R. , Joseph Jojo P. , Rajapakse B. Medini , Dutta Avisek , Das Rahul Kumar , Kuzmin Andrey , Baev Alexander , Velarde Luis , Prasad Paras N. , Swihart Mark T. 
Published: July 2024

AbstractPolymer‐based chiral materials with exceptional optical activity can dramatically impact integrated chiral photonics due to the tunability of their optical responses coupled with ease of fabrication. Realizing these applications requires increasing the absorbance dissymmetry factor. Here, in situ, the synthesis of gold nanostars is introduced in a chiral polymer medium to produce chiral polymer‐anisotropic plasmonic nanocrystal nanocomposites. The optimized nanocomposite shows a tenfold enhancement of dissymmetry factor, gabs (up to 0.64) and a corresponding 46‐fold augmented circular dichroism (CD) value upon annealing, relative to the annealed pure chiral polymer film. Moreover, the enhancement relative to the non‐annealed polymer‐gold nanostar nanocomposite is strikingly higher: a 35‐fold increase in gabs and a 4272‐fold increase in CD. Based on computational analysis, it is concluded that the local plasmon field enhancement around the crevices and tips of nanostars is mainly responsible for the observed effect which is further supported by a signal enhancement in Surface Enhanced Raman Scattering (SERS). Thus, this study underscores the significant role of close‐range plasmon interactions in altering the chiroptical response of nanocomposite materials and a practical pathway toward the realization of next‐generation integrated photonics and optoelectronic circuitry with photon spin control.
Wheel‐Running Exercise Alleviates Anxiety‐Like Behavior via Down‐Regulating S‐Nitrosylation of Gephyrin in the Basolateral Amygdala of Male Rats
Authors: Yang Ping‐Fen , Nie Tai‐Lei , Sun Xia‐Nan , Xu Lan‐Xin , Ma Cong , Wang Fang , Long Li‐Hong , Chen Jian‐Guo 
Published: July 2024

AbstractPhysical exercise has beneficial effect on anxiety disorders, but the underlying molecular mechanism remains largely unknown. Here, it is demonstrated that physical exercise can downregulate the S‐nitrosylation of gephyrin (SNO‐gephyrin) in the basolateral amygdala (BLA) to exert anxiolytic effects. It is found that the level of SNO‐gephyrin is significantly increased in the BLA of high‐anxiety rats and a downregulation of SNO‐gephyrin at cysteines 212 and 284 produced anxiolytic effect. Mechanistically, inhibition of SNO‐gephyrin by either Cys212 or Cys284 mutations increased the surface expression of GABAAR γ2 and the subsequent GABAergic neurotransmission, exerting anxiolytic effect in male rats. On the other side, overexpression of neuronal nitric oxide synthase in the BLA abolished the anxiolytic‐like effects of physical exercise. This study reveals a key role of downregulating SNO‐gephyrin in the anxiolytic effects of physical exercise, providing a new explanation for protein post‐translational modifications in the brain after exercise.
Volumetric Additive Manufacturing of Dicyclopentadiene by Solid‐State Photopolymerization
Authors: Hausladen Matthew M. , Baca Esteban , Nogales Kyle A. , Appelhans Leah N. , Kaehr Bryan , Hamel Craig M. , Leguizamon Samuel C. 
Published: July 2024

AbstractPolymerization in the solid state is generally infeasible due to restrictions on mobility. However, in this work, the solid‐state photopolymerization of crystalline dicyclopentadiene is demonstrated via photoinitiated ring‐opening metathesis polymerization. The source of mobility in the solid state is attributed to the plastic crystal nature of dicyclopentadiene, which yields local short‐range mobility due to orientational degrees of freedom. Polymerization in the solid state enables photopatterning, volumetric additive manufacturing of free‐standing structures, and fabrication with embedded components. Solid‐state photopolymerization of dicyclopentadiene offers a new paradigm for advanced and freeform fabrication of high‐performance thermosets.
S‐Block Metal Mg‐Mediated Co─N─C as Efficient Oxygen Electrocatalyst for Durable and Temperature‐Adapted Zn–Air Batteries
Authors: Wang Henan , Niu Xinxin , Liu Wenxian , Yin Ruilian , Dai Jiale , Guo Wei , Kong Chao , Ma Lu , Ding Xia , Wu Fangfang , Shi Wenhui , Deng Tianqi , Cao Xiehong 
Published: July 2024

AbstractIn the quest to enhance Zn–air batteries (ZABs) for operating across a wide spectrum of temperatures, synthesizing robust oxygen electrocatalysts is paramount. Conventional strategies focusing on orbital hybridization of d–d and p‐d aim to moderate the excessive interaction between the d‐band of the transition metal active site and oxygen intermediate, yet often yield suboptimal performance. Herein, an innovative s‐block metal modulation is reported to refine the electronic structure and catalytic behavior of Co─NC catalysts. Employing density functional theory (DFT) calculations, it is revealed that incorporating Mg markedly depresses the d‐band center of Co sites, thereby fine‐tuning the adsorption energy of the oxygen reduction reaction (ORR) intermediate. Consequently, the Mg‐modified Co─NC catalyst (MgCo─NC) unveils remarkable intrinsic ORR activity with a significantly reduced activation energy (Ea) of 10.0 kJ mol−1, outstripping the performance of both Co─NC (17.6 kJ mol−1), benchmark Pt/C (15.9 kJ mol−1), and many recent reports. Moreover, ZABs outfitted with the finely tuned Mg0.1Co0.9─NC realize a formidable power density of 157.0 mW cm−2, paired with an extremely long cycle life of 1700 h, and an exceptionally minimal voltage gap decay rate of 0.006 mV h−1. Further, the Mg0.1Co0.9─NC‐based flexible ZAB presents a mere 2% specific capacity degradation when the temperature fluctuates from 25 to −20 °C, underscoring its robustness and suitability for practical deployment in diverse environmental conditions.