bluuebunny/crossref_metadata_2025_split huggingface dataset:
B-Cell Maturation Antigen/CD19 Dual-Targeting Immunotherapy in Newly Diagnosed Multiple Myeloma
Authors: Qiang Wanting , Lu Jing , Jia Yanchun , Liu Jia , Liu Jin , He Haiyan , Wang Xiaoxiang , Fan Xiaoqiang , Jin Lina , Ruan Qianqi , Zhang Qi , Shen Lianjun , Weng Lihong , Cao Wei , Li Wenling , Du Juan 
Published: July 2024

ImportancePatients with high-risk newly diagnosed multiple myeloma (NDMM) often have poor outcomes with standard treatments, necessitating novel effective frontline therapies to enhance clinical outcomes. GC012F, a B-cell maturation antigen/CD19 dual-targeting chimeric antigen receptor (CAR) T-cell therapy, has been developed on the novel FasTCAR platform. Notably, its use as a frontline therapy for patients with high-risk NDMM who are eligible for transplant has not been thoroughly explored.ObjectiveTo examine the safety, pharmacokinetics, and patient health and survival outcomes associated with GC012F in individuals with NDMM.Design, Setting, and ParticipantsPatients were enrolled in this single-arm, open-label phase 1 cohort study between June 28, 2021, and June 1, 2023 (the data cutoff date). All patients included in this study were treated at a single center, Shanghai Changzheng Hospital. The patients in the efficacy evaluation were followed up for a minimum period of 3 months.InterventionPatients underwent 2 cycles of induction therapy, followed by GC012F infusion (at 1 × 105 cells/kg, 2 × 105 cells/kg, or 3 × 105 cells/kg).Main Outcomes and MeasuresThe primary goals were to assess the safety, efficacy, and pharmacokinetics of GC012F at various dose levels.ResultsOf 22 patients receiving GC012F treatment, 6 experienced mild to moderate cytokine release syndrome (grade 1-2) and none experienced neurotoxic effects. Nineteen patients were included in the efficacy evaluation, and all 19 patients showed stringent complete responses and achieved minimal residual disease negativity. The treatment’s effectiveness was consistent across different dose levels. GC012F demonstrated a rapid response, with a median time to first stringent complete response of 84 days (range, 26-267 days) and achieving minimal residual disease negativity within 28 days (range, 23-135 days). The CAR T-cell expansion was robust, with a median peak copy number of 60 652 copies/μg genomic DNA (range, 8754-331 159 copies/μg genomic DNA), and the median time to median peak copy number was 10 days (range, 9-14 days).Conclusions and RelevanceThe findings of this single-arm, open-label phase 1 cohort study suggest that GC012F may be a safe treatment associated with positive health and survival outcomes for patients with high-risk NDMM eligible for transplant. Owing to the small sample size, further studies with larger cohorts and longer follow-up durations are needed.
Guttae Morphology After Cultured Corneal Endothelial Cell Transplant in Fuchs Endothelial Corneal Dystrophy
Authors: Tomioka Yasufumi , Ueno Morio , Yamamoto Akihisa , Numa Kohsaku , Tanaka Hiroshi , Kitazawa Koji , Toda Munetoyo , Koizumi Noriko , Tanaka Motomu , Hamuro Junji , Sotozono Chie , Kinoshita Shigeru 
Published: July 2024

ImportanceWhether guttae in Fuchs endothelial corneal dystrophy (FECD) can be removed by polishing without Descemet stripping and whether postoperative maintenance of reduced guttae can be achieved through cultured corneal endothelial cell (CEC) transplant therapy are critical issues to be addressed.ObjectiveTo investigate the decrease of guttae through polishing degenerated CECs and abnormal extracellular matrix (ECM) without Descemet stripping and to observe the behavior of guttae following cultured CEC transplant.Design, Setting, and ParticipantsThis case series prospective observational study was conducted in a hospital outpatient clinic setting. Between December 2013 and January 2019, 22 eyes with corneal endothelial failure caused by FECD received cultured CEC transplant therapy at Kyoto Prefectural University Hospital. Of these, 15 eyes were consistently monitored at the same central corneal area during the preoperative phase, as well as in the early (within 1 year) and late (after 3 years) postoperative phases. The images from these phases were categorized into 3 groups: typical guttae, atypical guttae, and no guttae.ExposuresCultured CEC transplant therapy.Main OutcomesProportion of guttae in the observable area was measured, comparing the early and late postoperative phases for each group.ResultsThe mean age of the patients at the time of surgery was 69 years (range, 49-79 years). All 15 eyes exhibited the presence of confluent guttae preoperatively (100%). Among these, 3 of 15 eyes belonged to male patients. The early postoperative phase of guttae morphologies was classified into 3 groups: 5 eyes with typical guttae, 7 with atypical guttae, and 3 with no guttae. The decrease in the number of these guttae was achieved by surgical procedures. The median percentage of guttae in the typical guttae, atypical guttae, and no guttae groups was 41.8%, 44.4%, and 16.2%, respectively, in the early phase, and 42.2%, 38.2%, and 18.8%, respectively, in the late phase.Conclusions and RelevanceThe findings demonstrate that in some cases of FECD, guttae can be removed by scraping and polishing abnormal ECM and degenerated CECs, while preserving the Descemet membrane. Furthermore, cultured CEC transplant resulted in no increase in guttae for up to 3 years, providing insights into surgically eliminating guttae.
Highly Efficient Blue/Deep‐blue Circularly Polarized Electroluminescence with Small Efficiency Roll‐Offs
Authors: Yan Yan , Cheng Zhuang , Xu Yangze , Su Zihan , Wang Yaxue , He Xin , Zhao Zujin , Liu Futong , Lu Ping 
Published: July 2024

AbstractDeveloping efficient blue/deep‐blue circularly polarized organic light‐emitting diodes (CP‐OLEDs) with small efficiency roll‐off remains a great challenge for wide color gamut and high contrast 3D displays. Here, two pairs of chiral stable enantiomers, (R/S)‐PPI‐OBN‐CN and (R/S)‐PyI‐OBN‐CN, composed of imidazole derivatives phenanthroimidazole (PPI) and pyrenoimidazole (PyI) donors, and chiral group of (R/S)‐octahydro‐binaphthol (OBN‐CN) acceptor are designed. These new blue/deep‐blue molecular architectures exhibit excellent thermal and electrochemical stabilities, hybrid local and charge transfer (HLCT) excited state, and clear CPL characteristics with dissymmetry factors (|gPL|) of 1.57 × 10−3/2.49 × 10−3 in the neat films. Moreover, the CP‐OLEDs based on (R/S)‐PPI‐OBN‐CN and (R/S)‐PyI‐OBN‐CN exhibit the deep‐blue/pure‐blue emission with the CIE coordinates of (0.15, 0.08) and (0.15, 0.14), the maximum external quantum efficiencies (EQEs) of 7.25% and 8.11% and very small efficiency roll‐offs of 17.6% and 1.8% at the luminescence of 1000 cd m−2, respectively. Even when the brightness is increased to 10000 cd m−2, (R/S)‐PyI‐OBN‐CN‐based device could still maintain as high as 6.68%. Obvious circularly polarized electroluminescence (CPEL) activities with the EL dissymmetry factors (gEL) of +1.54 × 10−3/−1.63 × 10−3 and +1.95 × 10−3/−1.72 × 10−3 are also recorded. These are the first highly efficient blue/deep‐blue CP‐OLEDs based on “hot exciton” enantiomers.
Ultrahigh Responsivity and Robust Semiconducting Fiber Enabled by Molecular Soldering‐Governed Defect Engineering for Smart Textile Optoelectronics
Authors: Peng Hongyun , Liu Teng , Zhao Yinghe , Li Liang , Du Peipei , Li Huiqiao , Yan Feng , Zhai Tianyou 
Published: July 2024

AbstractSemiconducting fibers (SCFs) are of significant interest to design next‐generation wearable and comfortable optoelectronics that seamlessly integrate with textiles. However, the practical applications of current SCFs are always limited by poor optoelectronic performance and low mechanical robustness caused by uncontrollable multiscale structural defects. Herein, a versatile in situ molecular soldering‐governed defect engineering strategy is proposed to construct ultrahigh responsivity and robust wet‐spun MoS2 SCFs, by using a π‐conjugated dithiolated molecule to simultaneously patch microscale sulfur vacancies within MoS2 nanosheets, diminish mesoscale interlayer voids/wrinkles, promote macroscale orientation, build long‐range photoelectron percolation bridges, and provide n‐doping effect. The derived MoS2 SCFs exhibit over two orders of magnitude higher responsivity (144.3 A W−1) than previously reported fiber photodetectors, 37.3‐fold faster photoresponse speed (52 ms) than pristine counterpart, and remarkable bending robustness (retain 94.2% of the initial photocurrent after 50 000 bending‐flattening cycles). Such superior robustness and photodetection capacity of MoS2 SCFs further enable large‐scale weaving of reliable smart textile optoelectronic systems, such as direction‐identifiable wireless light alarming system, modularized mechano‐optical communication system, and indoor light‐controlled IoT system. This work offers a universal strategy for the scalable production of mechanically robust and high‐performance SCFs, opening up exciting possibilities for large‐scale integration of wearable optoelectronics.
Large Orientation Angle Buried Substrate Enables Efficient Flexible Perovskite Solar Cells and Modules
Authors: Tong Xinyu , Xie Lisha , Li Jun , Pu Zhenwei , Du Songyu , Yang Mengjin , Gao Yanyan , He Mingzhu , Wu Shaohang , Mai Yaohua , Ge Ziyi 
Published: July 2024

AbstractFlexible perovskite solar cells (f‐PSCs) have emerged as potential candidates for specific mechanical applications owing to their high foldability, efficiency, and portability. However, the power conversion efficiency (PCE) of f‐PSC remains limited by the inferior contact between perovskite and flexible buried substrate. Here, an asymmetric π‐extended self‐assembled monolayer (SAM) (4‐(9H‐dibenzo[a,c]carbazol‐9‐yl)butyl)phosphonic acid (A‐4PADCB) is reported as a buried substrate for efficient inverted f‐PSCs. Employing this design strategy, A‐4PADCB exhibits a significant orientation angle away from the surface normal, homogenizing the distribution of contact potentials. This enhancement improves the SAM/perovskite interface quality, controlling the growth of favorable perovskite films with low defect density and slight tensile stress. Integration of A‐4PADCB into small‐area f‐PSCs and large‐area flexible perovskite solar modules with an aperture area of 20.84 cm2 achieves impressive PCEs of up to 25.05% and 20.64% (certified 19.51%), respectively. Moreover, these optimized A‐4PADCB‐based f‐PSCs possess enhanced light, thermal, and mechanical stability. This research paves a promising avenue toward the design of SAM‐buried substrates with a large orientation angle, regulating perovskite growth, and promoting the commercialization of large‐area flexible perovskite photovoltaics.
Immuno‐Nanocomplexes Target Heterogenous Network of Inflammation and Immunity in Myocardial Infarction
Authors: Su Fan , Ye Weifan , Shen Yi , Xie Yujie , Zhang Chong , Zhang Qianyun , Tang Zhengqi , Yu Meihua , Chen Yu , He Bin 
Published: July 2024

AbstractDespite the proceeds in the management of acute myocardial infarction (AMI), the current therapeutic landscape still suffers from limited success in the clinic. Exaggerated inflammatory immune response and excessive oxidative stress are key pathological features aggravating myocardium damage. Herein, catalytic immunomodulatory nanocomplexes as anti‐AMI therapeutics to resolve reactive oxygen species (ROS)‐proinflammatory neutrophils‐specific‐inflammation is engineered. The nanocomplexes contain lyophilic S100A8/9 inhibitor ABR2575 in the core of nanoemulsions, which effectively disrupts the neutrophils‐S100A8/A9‐inflammation signaling pathway in the AMI microenvironment. Additionally, ROS scavenger ultrasmall CuxO nanoparticles are incorporated into the nanoemulsions via coordinating with SH groups of poly(ethylene glycol) (PEG)‐conjugated lipids, which mimic multiple enzymes, dramatically alleviating the oxidative stress damage to myocardial tissue. This combination strategy significantly suppresses the infiltration of pro‐inflammatory monocytes, macrophages, and neutrophils, as well as the secretion of inflammatory cytokines. Additionally, it potentially triggers cardiac Tert activation, which promotes myocardial function and decreases infarction size in preclinical murine AMI models. This approach offers a new nanomedicine for treating AMI, resulting in a dramatically enhanced therapeutic outcome.
A Scalable and Robust Water Management Strategy for PEMFCs: Operando Electrothermal Mapping and Neutron Imaging Study
Authors: Xu Linlin , Trogadas Panagiotis , Zhou Shangwei , Jiang Shuxian , Wu Yunsong , Rasha Lara , Kockelmann Winfried , Yang Jia Di , Neville Toby , Jervis Rhodri , Brett Dan J. L. , Coppens Marc‐Olivier 
Published: July 2024

AbstractEffective water management is crucial for the optimal operation of low‐temperature polymer electrolyte membrane fuel cells (PEMFCs). Excessive liquid water production can cause flooding in the gas diffusion electrodes and flow channels, limiting mass transfer and reducing PEMFC performance. To tackle this issue, a nature‐inspired chemical engineering (NICE) approach has been adopted that takes cues from the integument structure of desert‐dwelling lizards for passive water transport. By incorporating engraved, capillary microchannels into conventional flow fields, PEMFC performance improves significantly, including a 15% increase in maximum power density for a 25 cm2 cell and 13% for a 100 cm2 cell. Electro‐thermal maps of the lizard‐inspired flow field demonstrate a more uniform spatial distribution of current density and temperature than the conventional design. Neutron radiography provides evidence that capillary microchannels in the lizard‐inspired flow field facilitate the efficient transport and removal of generated liquid water, thereby preventing blockages in the reactant channels. These findings present a universally applicable and highly efficient water management strategy for PEMFCs, with the potential for widespread practical implementation for other electrochemical devices.
Role of STAT3‐FOXO3 Signaling in the Modulation of Neuroplasticity by PD‐L1‐HGF‐Decorated Mesenchymal Stem Cell‐Derived Exosomes in a Murine Stroke Model
Authors: Lin Syuan‐Ling , Chang Yi‐Wen , Lee Wei , Chiang Chih‐Sheng , Liu Shih‐Ping , Lee Hsu‐Tung , Jeng Long‐Bin , Shyu Woei‐Cherng 
Published: July 2024

AbstractThe limited therapeutic strategies available for stroke leave many patients disabled for life. This study assessed the potential of programmed death‐ligand 1 (PD‐L1) and hepatocyte growth factor (HGF)‐engineered mesenchymal stem cell‐derived exosomes (EXO‐PD‐L1‐HGF) in enhancing neurological recovery post‐stroke. EXO‐PD‐L1‐HGF, which efficiently endocytosed into target cells, significantly diminishes the H2O2‐induced neurotoxicity and increased the antiapoptotic proteins in vitro. EXO‐PD‐L1‐HGF attenuates inflammation by inhibiting T‐cell proliferation and increasing the number of CD8+CD122+IL‐10+ regulatory T cells. Intravenous injection of EXO‐PD‐L1‐HGF could target stromal cell‐derived factor‐1α (SDF‐1α+) cells over the peri‐infarcted area of the ischemic brain through CXCR4 upregulation and accumulation in neuroglial cells post‐stroke. EXO‐PD‐L1‐HGF facilitates endogenous nestin+ neural progenitor cell (NPC)‐induced neurogenesis via STAT3‐FOXO3 signaling cascade, which plays a pivotal role in cell survival and neuroprotection, thereby mitigating infarct size and enhancing neurological recovery in a murine stroke model. Moreover, increasing populations of the immune‐regulatory CD19+IL‐10+ and CD8+CD122+IL‐10+ cells, together with reducing populations of proinflammatory cells, created an anti‐inflammatory microenvironment in the ischemic brain. Thus, innovative approaches employing EXO‐PD‐L1‐HGF intervention, which targets SDF‐1α+ expression, modulates the immune system, and enhances the activation of resident nestin+ NPCs, might significantly alter the brain microenvironment and create a niche conducive to inducing neuroplastic regeneration post‐stroke.
Hierarchical Supramolecular Aggregation of Molecular Nanoparticles for Granular Materials with Ultra High‐Speed Impact‐Resistance
Authors: Zhou Xin , Yin Jia‐Fu , Chen Cong , Chi Yanjie , Chen Jiadong , Liu‐Fu Wei , Yang Junsheng , Long Shuchang , Tang Liqun , Yao Xiaohu , Yin Panchao 
Published: July 2024

AbstractThe high‐speed impact‐resistanct materials are of great significance while their development is hindered by the intrinsic tradeoff between mechanical strength and energy dissipation capability. Herein, the new chemical system of molecular granular material (MGM) is developed for the design of impact‐resistant materials from the supramolecular complexation of sub‐nm molecular clusters (MCs) and hyper‐branched polyelectrolytes. Their hierarchical aggregation provides the origin of the decoupling of mechanical strengths and structural relaxation dynamics. The MCs’ intrinsic fast dynamics afford excellent high‐speed impact‐resistance, up to 5600 s−1 impact in a typical split‐Hopkinson pressure bar test while only tiny boundary cracks can be observed even under 7200 s−1 impact. The high loadings of MCs and their hierarchical aggregates provide high‐density sacrificial bonding for the effective dissipation of the impact energy, enabling the protection of fragile devices from the direct impact of over 200 m s−1 bullet. Moreover, the MGMs can be conveniently processed into protective coatings or films with promising recyclability due to the supramolecular interaction feature. The research not only reveals the unique relaxation dynamics and mechanical properties of MGMs in comparison with polymers and colloids, but also develops new chemical systems for the fabrication of high‐speed impact‐resistant materials.
Amorphous Nanomaterials: Emerging Catalysts for Electrochemical Carbon Dioxide Reduction
Authors: Tan Menglin , Huang Biao , Su Lina , Jiao Xinran , Feng Fukai , Gao Yixuan , Huang Qianli , Huang Zhiqi , Ge Yiyao 
Published: July 2024

AbstractIn the past decades, the rapid depletion of non‐renewable energy sources has caused growing energy crisis and increasing emissions of carbon dioxide (CO2), which aggravates global warming and catastrophic climate change. Electrocatalysis is regarded as an effective method for consuming atmospheric CO2 and simultaneously alleviating the energy problem by converting CO2 into high value‐added chemicals. Amorphous nanomaterials with long‐range disordered structures possess abundant highly unsaturated atomic sites and dangling bonds on their surfaces, thus providing a large number of active sites, and show unique electronic structures compared to their crystalline counterparts due to the distinct atomic arrangements. Therefore, amorphous nanomaterials are recently demonstrated as highly efficient catalysts for diverse electrocatalytic reactions, including electrocatalytic CO2 reduction reaction (CO2RR). Here the rational synthesis and electrocatalytic performance of newly emerging amorphous nanomaterials will be outlined for electrocatalytic CO2RR. Importantly, the intrinsic merits of these amorphous catalysts in CO2RR processes will be summarized and highlighted. Finally, these perspectives on the remaining challenges and some potential future directions in this emerging field will also be provided.
Advances in the Synthesis of 1,3‐Disubstituted Ferrocene Derivatives: From Stoichiometric to Catalytic Methods
Authors: Santamaría Javier , García‐Martínez Patricia , López Luis A. 
Published: July 2024

AbstractFunctionalized ferrocene derivatives have a wide range of applications across various scientific fields. Although significant progress has been made in synthesizing 1,2‐disubstituted ferrocene derivatives, the preparation of 1,3‐disubstituted ferrocenes remains challenging. Recently, however, several powerful synthetic approaches to 1,3‐disubstituted ferrocenes have been reported. This review aims to present the evolution of these synthetic methods, from initial stoichiometric approaches to the more recent catalytic methodologies.
New quantitative analyses of the Nacholapithecus kerioi proximal ulna confirm morphological affinities with Equatorius and large papionins
Authors: Pina Marta , Nakatsukasa Masato 
Published: July 2024

AbstractObjectivesThe elbow of Nacholapithecus has been extensively described qualitatively, however its ulnar morphology has never been the focus of an in‐depth quantitative analysis before. Hence, our main aim is quantifying the proximal ulnar morphology in Nacholapithecus and exploring whether it is similar to those of Equatorius and Griphopithecus as previously reported.Materials and MethodsWe compared Nacholapithecus proximal ulnar morphology with a sample of extant and extinct anthropoids through principal component analysis and agglomerative hierarchical cluster analysis. Moreover, we calculated the Cophenetic Correlation Coefficient and checked for taxonomical group mean differences through MANOVA and pairwise post‐hoc comparisons, as well as the phylogenetic signal in the variables used.ResultsThe Nacholapithecus ulna displays a moderately long and relatively narrow olecranon, a relatively wide trochlear surface‐radial notch width, and a relatively thin sigmoid notch depth. These features resemble those of large papionins and chimpanzees, and some extinct taxa, mainly Equatorius.DiscussionResults presented here reinforce previous inferences on the functional morphology of the Nacholapithecus elbow, showing adaptations for general quadrupedal behaviors. However, other derived features (e.g., a relatively wide trochlear surface) might be associated with the ape‐like traits described for its distal humerus (e.g., wide trochlear groove), thus displaying a combination of primitive and derived features in the proximal ulna. Finally, affinities with large papionins could suggest the presence of some terrestrial habits in Nacholapithecus. However, the lack of evidence in the rest of the skeleton prevents us from suggesting terrestrial affinities in this taxon in a conclusive manner.
Ontogenetic biomechanics of tufted (Sapajus) and untufted (Cebus) capuchin mandibles
Authors: Polvadore Taylor A. , Yoakum Caitlin B. , Taylor Parker M. , Holmes Megan A. , Laird Myra F. , Chalk‐Wilayto Janine , Kanno Cláudia Misue , de Oliveira José Américo , Terhune Claire E. 
Published: July 2024

AbstractObjectivesCortical bone geometry is commonly used to investigate biomechanical properties of primate mandibles. However, the ontogeny of these properties is less understood. Here we investigate changes in cortical bone cross‐sectional properties throughout capuchin ontogeny and compare captive versus wild, semi‐provisioned groups. Tufted capuchins (Sapajus spp.) are known to consume relatively hard/tough foods, while untufted capuchins (Cebus spp.) exploit less mechanically challenging foods. Previous research indicates dietary differences are present early in development and adult Sapajus mandibles can resist higher bending/shear/torsional loads.Materials and methodsThis study utilized microCT scans of 22 Cebus and 45 Sapajus from early infancy to adulthood from three sample populations: one captive Cebus, one captive Sapajus, and one semi‐provisioned, free‐ranging Sapajus. Mandibular cross‐sectional properties were calculated at the symphysis, P3, and M1. If the tooth had not erupted, its position within the crypt was used. A series of one‐way ANOVAs were performed to assess differences between and within the sample populations.ResultsMandible robusticity increases across ontogeny for all three sample populations. Sapajus were better able to withstand bending and torsional loading even early in ontogeny, but no difference in shear resistance was found. Semi‐provisioned, free‐ranging Sapajus tend to show increased abilities to resist bending and torsional loading but not shear loading compared to captive Sapajus.DiscussionThis study helps advance our understanding of the primate masticatory system development and opens the door for further studies into adaptive plasticity in shaping the masticatory apparatus of capuchins and differences in captive versus free‐ranging sample populations.