bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact on short-term glycaemic control of initiating diabetes care versus leaving diabetes untreated among individuals with newly screening-detected diabetes in Japan
Authors: Heianza Yoriko , Suzuki Akiko , Fujihara Kazuya , Tanaka Shiro , Kodama Satoru , Hanyu Osamu , Sone Hirohito 
Published: September 2014

BackgroundThe impact of early initiation of diabetes care soon after the identification of hyperglycaemia rather than leaving diabetes untreated on changes in glycaemic control has not been fully clarified. We aimed to quantify the effect of initiating and continuing diabetes care compared with not starting management of diabetes on short-term changes in glycaemic control among the Japanese with newly screening-detected diabetes.MethodsWe retrospectively reviewed data from a nationwide claims database to assess histories of physician-diagnosed diabetes or hyperglycaemia, as well as the use of antidiabetic agents, blood testing for hyperglycaemia or dietary advice among individuals without a history of diabetes care. Changes in glycated haemoglobin (HbA1c) concentrations were evaluated using baseline data and data from a health examination during the following year.ResultsAmong 1393 individuals with newly screening-detected diabetes, 62% (n=864) did not initiate diabetes management during the follow-up period; 49.2% (n=425) of the untreated group had poor glycaemic control (HbA1c ≥7%) at the baseline examination. Only 38% (n=529) began diabetes management in medical settings. Individuals who remained untreated had a 1.87 (95% CI 1.38 to 2.52) or 1.63 (1.10 to 2.41) times higher risk of absolute increases in HbA1c ≥0.5% or ≥1%, respectively, compared with the treated patients, a difference that was significant. Making more frequent clinic visits especially after the first visit was dose-dependently associated with improved HbA1c levels compared with no diabetes management.ConclusionsIn comparison with a lack of management of diabetes, immediately initiating and continuing diabetes care after identification of hyperglycaemia in a screening setting would contribute to clinically meaningful, improved glycaemic control in the Japanese.
Minimally invasive evacuation of parenchymal and ventricular hemorrhage using the Apollo system with simultaneous neuronavigation, neuroendoscopy and active monitoring with cone beam CT
Authors: Fiorella David , Gutman Fredrick , Woo Henry , Arthur Adam , Aranguren Ricardo , Davis Raphael 
Published: September 2014

IntroductionThe Apollo system is a low profile irrigation–aspiration system which can be used for the evacuation of intracranial hemorrhage. We demonstrate the feasibility of using Apollo to evacuate intracranial hemorrhage in a series of three patients with combined neuronavigation, neuroendoscopy, and cone beam CT (CB-CT).MethodsAccess to the hematoma was planned using neuronavigation software. Parietal (n=2) or frontal (1) burr holes were created and a 19 F endoscopic sheath was placed under neuronavigation guidance into the distal aspect of the hematoma along its longest accessible axis. The 2.6 mm Apollo wand was then directed through the working channel of a neuroendoscope and used to aspirate the blood products under direct visualization, working from distal to proximal. After a pass through the hematoma, the sheath, neuroendoscope, and Apollo system were removed. CB-CT was then used to evaluate for residual hematoma. When required, the CB-CT data could then be directly uploaded into the neuronavigation system and a new trajectory planned to approach the residual hematoma.ResultsThree patients with parenchymal (n=2) and mixed parenchymal–intraventricular (n=1) hematomas underwent minimally invasive evacuation with the Apollo system. The isolated parenchymal hematomas measured 93.4 and 15.6 mL and were reduced to 11.2 (two passes) and 0.9 mL (single pass), respectively. The entire parenchymal component of the mixed hemorrhage was evacuated, as was the intraventricular component within the right frontal horn (single pass). No complications were experienced. All patients showed clinical improvement after the procedure. The average presenting National Institutes of Health Stroke Scale was 19.0, which had improved to 5.7 within an average of 4.7 days after the procedure.ConclusionsThe Apollo system can be used within the neuroangiography suite for the minimally invasive evacuation of intracranial hemorrhage using simultaneous neuronavigation for planning and intraprocedural guidance, direct visualization with neuroendoscopy, and real time monitoring of progress with CB-CT.
Colmenar Limestone, Madrid, Spain: considerations for its nomination as a Global Heritage Stone Resource due to its long term durability
Authors: Fort R. , Varas-Muriel M. J. , Alvarez de Buergo M. , Perez-Monserrat E. M. 
Published: September 2014

Abstract
Colmenar Limestone is one of the traditional materials most commonly used in monuments in Madrid, Spain. The petrophysical properties of this stone determine its high resistance to decay. Its low water absorption and pore size distribution favour good hydraulic behaviour, which is likewise furthered by its high ultrasound velocity and low anisotropy. The durability findings pursuant to the 280 freeze–thaw, 42 thermal shock, 30 salt crystallization and 120 salt mist cycles conducted confirmed the stone's resistance to decay in these simulated aggressive environments. The mass loss recorded in the samples and the variation in petrophysical parameters were generally very low after all except the salt crystallization trials, which induced loss of cohesion on the stone surface, increased roughness and the formation of concentric microcracks, sub-parallel to the more exposed surface, that also affected the arris and vertices of the specimens tested.
Stress Response Protein Cirp Links Inflammation and Tumorigenesis in Colitis-Associated Cancer
Authors: Sakurai Toshiharu , Kashida Hiroshi , Watanabe Tomohiro , Hagiwara Satoru , Mizushima Tsunekazu , Iijima Hideki , Nishida Naoshi , Higashitsuji Hiroaki , Fujita Jun , Kudo Masatoshi 
Published: September 2014

AbstractColitis-associated cancer (CAC) is caused by chronic intestinal inflammation and is reported to be associated with refractory inflammatory bowel disease (IBD). Defective apoptosis of inflammatory cell populations seems to be a relevant pathogenetic mechanism in refractory IBD. We assessed the involvement of stress response protein cold-inducible RNA-binding protein (Cirp) in the development of intestinal inflammation and CAC. In the colonic mucosa of patients with ulcerative colitis, expression of Cirp correlated significantly with the expression of TNFα, IL23/IL17, antiapoptotic proteins Bcl-2 and Bcl-xL, and stem cell markers such as Sox2, Bmi1, and Lgr5. The expression of Cirp and Sox2 was enhanced in the colonic mucosae of refractory ulcerative colitis, suggesting that Cirp expression might be related to increased cancer risk. In human CAC specimens, inflammatory cells expressed Cirp protein. Cirp−/− mice given dextran sodium sulfate exhibited decreased susceptibility to colonic inflammation through decreased expression of TNFα, IL23, Bcl-2, and Bcl-xL in colonic lamina propria cells compared with similarly treated wild-type (WT) mice. In the murine CAC model, Cirp deficiency decreased the expression of TNFα, IL23/IL17, Bcl-2, Bcl-xL, and Sox2 and the number of Dclk1+ cells, leading to attenuated tumorigenic potential. Transplantation of Cirp−/− bone marrow into WT mice reduced tumorigenesis, indicating the importance of Cirp in hematopoietic cells. Cirp promotes the development of intestinal inflammation and colorectal tumors through regulating apoptosis and production of TNFα and IL23 in inflammatory cells. Cancer Res; 74(21); 6119–28. ©2014 AACR.
The Genomic Landscape of Pediatric Ewing Sarcoma
Authors: Crompton Brian D. , Stewart Chip , Taylor-Weiner Amaro , Alexe Gabriela , Kurek Kyle C. , Calicchio Monica L. , Kiezun Adam , Carter Scott L. , Shukla Sachet A. , Mehta Swapnil S. , Thorner Aaron R. , de Torres Carmen , Lavarino Cinzia , Suñol Mariona , McKenna Aaron , Sivachenko Andrey , Cibulskis Kristian , Lawrence Michael S. , Stojanov Petar , Rosenberg Mara , Ambrogio Lauren , Auclair Daniel , Seepo Sara , Blumenstiel Brendan , DeFelice Matthew , Imaz-Rosshandler Ivan , Schwarz-Cruz y Celis Angela , Rivera Miguel N. , Rodriguez-Galindo Carlos , Fleming Mark D. , Golub Todd R. , Getz Gad , Mora Jaume , Stegmaier Kimberly 
Published: September 2014

Abstract
Pediatric Ewing sarcoma is characterized by the expression of chimeric fusions of EWS and ETS family transcription factors, representing a paradigm for studying cancers driven by transcription factor rearrangements. In this study, we describe the somatic landscape of pediatric Ewing sarcoma. These tumors are among the most genetically normal cancers characterized to date, with only EWS–ETS rearrangements identified in the majority of tumors. STAG2 loss, however, is present in more than 15% of Ewing sarcoma tumors; occurs by point mutation, rearrangement, and likely nongenetic mechanisms; and is associated with disease dissemination. Perhaps the most striking finding is the paucity of mutations in immediately targetable signal transduction pathways, highlighting the need for new therapeutic approaches to target EWS–ETS fusions in this disease.
Significance: We performed next-generation sequencing of Ewing sarcoma, a pediatric cancer involving bone, characterized by expression of EWS–ETS fusions. We found remarkably few mutations. However, we discovered that loss of STAG2 expression occurs in 15% of tumors and is associated with metastatic disease, suggesting a potential genetic vulnerability in Ewing sarcoma. Cancer Discov; 4(11); 1326–41. ©2014 AACR.
This article is highlighted in the In This Issue feature, p. 1243
Organ-specific bleeding patterns of anticoagulant therapy: lessons from clinical trials
Authors: Vanassche Thomas , Hirsh Jack , Ginsberg Jeffrey , Eikelboom John 
Published: September 2014

SummaryAnticoagulants are effective at preventing and treating thrombosis, but can cause bleeding. For decades, vitamin K antagonists (VKAs) have been the only available oral anticoagulants. The development of non-VKA oral anticoagulants (NOACs), which inhibit either factor Xa or thrombin stoichiometrically, has provided alternatives to VKAs for several indications. The results of recent large-scale randomised controlled trials comparing NOACs with VKAs for the prevention of stroke in patients with non-valvular atrial fibrillation (AF) have produced some unexpected results. As a group, NOACs showed similar efficacy as warfarin, but a reduced risk of major bleeding. The reduction in bleeding with NOACs was greatest with intracranial hemorrhage. In contrast, the relative risk of gastro-intestinal bleeding was increased with some NOACs. In this review, we explore the potential mechanisms as well as the implications of these organ-specific bleeding patterns.
ABO blood group and thrombotic vascular disease
Authors: Mannucci Pier Mannuccio , Franchini Massimo 
Published: September 2014

SummaryABO blood group antigens are complex carbohydrate molecules expressed on red blood cells and a variety of tissues. The ABO blood type is implicated in the development of a number of human diseases and there is increasing evidence regarding its involvement in the pathogenesis of cardiovascular disorders, mainly through its effect on von Willebrand factor levels. In this review, after a brief analysis of the potential molecular mechanisms by which the blood group influences haemostasis, we focus on the clinical implications of such interaction. Overall, the literature data document the close relationship between venous thromboembolism (VTE) and non-O blood type, which is associated with an approximately two-fold increased risk of venous thrombosis. A supra-additive effect on VTE risk is observed when an inherited thrombophilic condition is associated with non-O blood group. A weaker association exists between non-O blood type and arterial thrombosis, which needs to be further investigated.
Redefining Expectations of Long-Term Survival After the Fontan Procedure
Authors: d’Udekem Yves , Iyengar Ajay J. , Galati John C. , Forsdick Victoria , Weintraub Robert G. , Wheaton Gavin R. , Bullock Andrew , Justo Robert N. , Grigg Leeanne E. , Sholler Gary F. , Hope Sarah , Radford Dorothy J. , Gentles Thomas L. , Celermajer David S. , Winlaw David S. 
Published: September 2014

Background—
The life expectancy of patients undergoing a Fontan procedure is unknown.

Methods and Results—

Follow-up of all 1006 survivors of the 1089 patients who underwent a Fontan procedure in Australia and New Zealand was obtained from a binational population-based registry including all pediatric and adult cardiac centers. There were 203 atriopulmonary connections (AP; 1975–1995), 271 lateral tunnels (1988–2006), and 532 extracardiac conduits (1997–2010). The proportion with hypoplastic left heart syndrome increased from 1/173 (1%) before 1990 to 80/500 (16%) after 2000. Survival at 10 years was 89% (84%–93%) for AP and 97% (95% confidence interval [CI], 94%–99%) for lateral tunnels and extracardiac conduits. The longest survival estimate was 76% (95% CI, 67%–82%) at 25 years for AP. AP independently predicted worse survival compared with extracardiac conduits (hazard ratio, 6.2;
P
<0.001; 95% CI, 2.4–16.0). Freedom from failure (death, transplantation, takedown, conversion to extracardiac conduits, New York Heart Association III/IV, or protein-losing enteropathy/plastic bronchitis) 20 years after Fontan was 70% (95% CI, 63%–76%). Hypoplastic left heart syndrome was the primary predictor of Fontan failure (hazard ratio, 3.8;
P
<0.001; 95% CI, 2.0–7.1). Ten-year freedom from failure was 79% (95% CI, 61%–89%) for hypoplastic left heart syndrome versus 92% (95% CI, 87%–95%) for other morphologies.

Conclusions—
The long-term survival of the Australia and New Zealand Fontan population is excellent. Patients with an AP Fontan experience survival of 76% at 25 years. Technical modifications have further improved survival. Patients with hypoplastic left heart syndrome are at higher risk of failure. Large, comprehensive registries such as this will further improve our understanding of late outcomes after the Fontan procedure.
Prevalence and Long-Term Outcome of Aortic Prosthesis–Patient Mismatch in Patients With Paradoxical Low-Flow Severe Aortic Stenosis
Authors: Mohty Dania , Boulogne Cyrille , Magne Julien , Pibarot Philippe , Echahidi Najmeddine , Cornu Elisabeth , Dumesnil Jean , Laskar Marc , Virot Patrice , Aboyans Victor 
Published: September 2014

Background—
Patients with severe aortic stenosis (AS) and paradoxical low flow (PLF) have worse outcome compared with those with normal flow. Furthermore, prosthesis–patient mismatch (PPM) after aortic valve replacement is a predictor of reduced survival. However, the prevalence and prognostic impact of PPM in patients with PLF-AS are unknown. We aimed to analyze the prevalence and long-term survival of PPM in patients with PLF-AS.

Methods and Results—

Between 2000 and 2010, 677 patients with severe AS, preserved left ventricular ejection fraction, and aortic valve replacement were included (74±8 years; 42% women; aortic valve area, 0.69±0.16 cm
2
). A PLF (indexed stroke volume ≤35 mL/m
2
) was found in 26%, and after aortic valve replacement, 54% of patients had PPM, defined as an indexed effective orifice area ≤0.85 cm
2
/m
2
. The combined presence of PLF and PPM was found in 15%. Compared with patients with noPLF/noPPM, those with PLF/PPM were significantly older, with more comorbidities. They also received smaller and biological bioprosthesis more often (all
P
<0.01). Although early mortality was not significantly different between groups, the 10-year survival rate was significantly reduced in case of PLF/PPM compared with noPLF/noPPM (38±9% versus 70±5%;
P
=0.002), even after multivariable adjustment (hazard ratio, 2.58; 95% confidence interval, 1.5–4.45;
P
=0.0007).

Conclusions—
In this large catheterization-based study, the coexistence of PLF-AS before surgery and PPM after surgery is associated with the poorest outcome.
‘Soft’ Coercive Diplomacy versus Informal Resistance: Attempts at Deporting ‘Illegal Vietnamese’ from Reunifying Germany, 1990-1995
Authors: Maass Matthias 
Published: September 2014

During the period of Germany’s reunification in the early 1990s, disagreement between Germany and Vietnam over the return of Vietnamese individuals to Vietnam escalated into a diplomatic dispute that also spilled over into Vietnam’s negotiations with the European Union over a major eu–Vietnam treaty. In mid-1995, however, the German and Vietnamese governments finally agreed on a repatriation arrangement that allowed Germany to begin deporting about 40,000 Vietnamese who were living in Germany illegally.
This article explores the episode in the wider context of diplomatic dispute resolution. While Germany was demanding full cooperation from Vietnam on the issue of returning Vietnamese nationals, the Vietnamese government initially resisted large-scale repatriation for economic and social reasons. Hanoi attempted to frame the discussion within bilateral negotiations, economic costs and human rights, whereas Bonn argued from the perspective of customary international law and applied increasingly coercive diplomacy. German authorities escalated the disagreement and made economic threats with the aim of changing Hanoi’s behaviour.
In order to frame this approach analytically, this article uses a modified form of coercive diplomacy. The analysis proceeds in three stages: first, the article analyses the origins of the dispute, which had its roots in German reunification; second, it evaluates the legal arguments advanced by each side; and third, it investigates Germany’s ‘soft’ coercive diplomacy and Vietnam’s response. The article concludes with an evaluation of Germany’s approach, benchmarking 1995’s diplomatic outcome against results on the ground, namely the number of returnees to Vietnam.
Intense and Extreme Wind Speeds Observed by Anemometer and Seismic Networks: An Eastern U.S. Case Study
Authors: Pryor S. C. , Conrick R. , Miller C. , Tytell J. , Barthelmie R. J. 
Published: September 2014

AbstractThe scale and intensity of extreme wind events have tremendous relevance to determining the impact on infrastructure and natural and managed ecosystems. Analyses presented herein show the following. 1) Wind speeds in excess of the station-specific 95th percentile are coherent over distances of up to 1000 km over the eastern United States, which implies that the drivers of high wind speeds are manifest at the synoptic scale. 2) Although cold fronts associated with extratropical cyclones are a major cause of high–wind speed events, maximum sustained and gust wind speeds are only weakly dependent on the near-surface horizontal temperature gradient across the front. 3) Gust factors (GF) over the eastern United States have a mean value of 1.57 and conform to a lognormal probability distribution, and the relationship between maximum observed GF and sustained wind speed conforms to a power law with coefficients of 5.91 and −0.499. Even though there is coherence in the occurrence of intense wind speeds at the synoptic scale, the intensity and spatial extent of extreme wind events are not fully characterized even by the dense meteorological networks deployed by the National Weather Service. Seismic data from the USArray, a program within the Earthscope initiative, may be suitable for use in mapping high-wind and gust events, however. It is shown that the seismic channels exhibit well-defined spectral signatures under conditions of high wind, with a variance peak at frequencies of ~0.04 s−1 and an amplitude that appears to scale with the magnitude of observed wind gusts.
Large-Eddy Simulation of a Residual Layer: Low-Level Jet, Convective Rolls, and Kelvin–Helmholtz Instability
Authors: Nakanishi Mikio , Shibuya Ryosuke , Ito Junshi , Niino Hiroshi 
Published: September 2014

Abstract
Diurnal variations of an atmospheric boundary layer from 0900 LST on day 33 to 0600 LST on day 34 of the Wangara experiment are studied using a large-eddy simulation (LES) model that includes longwave radiation and baroclinicity. The present study directs its particular attention to phenomena in a residual layer (RL). As the surface heat flux decreases, an inertial oscillation is initiated and is accompanied by a low-level jet (LLJ) at a height of approximately 200 m. The maximum wind speed of the LLJ exceeds 12 m s−1 at 0300 LST on day 34. After 2100 LST on day 33, the horizontal advection due to the LLJ under a large-scale horizontal gradient of temperature destabilizes the RL and consequently induces horizontal convective rolls, parallel to a vertical wind shear (VWS) vector, between heights of 400 and 1400 m. The VWS in the layer between the bottom of the convective rolls and the gradually growing LLJ maximum is intensified after midnight, and the gradient Richardson number falls below its critical value of 0.25 at a height of 400 m at 0130 LST on day 34. An empirical orthogonal function analysis demonstrates that Kelvin–Helmholtz (KH) vortices appear below the convective rolls and are coupled with them. This study suggests that horizontal convective rolls can occur in an RL because an LLJ often advects warmer air to the lower layer according to a large-scale gradient of temperature and that the rolls may coexist with KH vortices in a stable boundary layer because the LLJ gradually increases a VWS.
Isolating the Role of Surface Evapotranspiration on Moist Convection along the Eastern Flanks of the Tropical Andes Using a Quasi-Idealized Approach*
Authors: Sun Xiaoming , Barros Ana P. 
Published: September 2014

AbstractThe contribution of surface evapotranspiration (ET) to moist convection, cloudiness, and precipitation along the eastern flanks of the tropical Andes (EADS) was investigated using the Weather Research and Forecasting (WRF) Model with nested simulations of selected weather conditions down to 1.2-km grid spacing. To isolate the role of surface ET, numerical experiments were conducted using a quasi-idealized approach whereby, at every time step, the surface sensible heat effects are exactly the same as in the reference simulations, whereas the surface latent heat fluxes are prevented from entering the atmosphere. Energy balance analysis indicates that surface ET influences moist convection primarily through its impact on conditional instability, because it acts as an important source of moist entropy in this region. The energy available for convection decreases by up to approximately 60% when the ET contribution is withdrawn. In contrast, when convective motion is not thermally driven or under conditionally stable conditions, the role of latent heating from the land surface becomes secondary. At the scale of the Andes proper, removal of surface ET weakens upslope flows by increasing static stability of the lower troposphere, as the vertical gradient of water vapor mixing ratio tends to be less negative. Consequently, moisture convergence is reduced over the EADS. In the absence of surface ET, this process operates in concert with damped convective energy, suppressing cloudiness and decreasing daily precipitation by up to around 50% in the simulations presented here.