bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustainable construction: the use of cork material in the building industry
Authors: Yadav Madhura , Singhal Ishika 
Published: August 2024

AbstractIn the ongoing quest for sustainable construction practices, the exploration of innovative materials is paramount, and cork has emerged as a remarkable eco-friendly building material with vast untapped potential. Cork, harvested from the bark of cork oak trees without harming them, possesses a unique combination of qualities that make it an ideal candidate for environmentally conscious construction. Cork is exceptionally renewable and biodegradable. What makes cork even more promising is its compatibility with various existing construction materials, including cement, plastic, and plywood. By integrating cork with these materials, we can improve their structural integrity, thermal performance, and acoustic insulation, while reducing their environmental impact. By harnessing the potential of cork and seamlessly merging its exceptional performance with a planet-conscious approach, the construction industry can significantly reduce its ecological footprint. Cork emerges as a compelling contender in shaping a greener, more resilient construction landscape, offering a sustainable alternative that aligns with our growing commitment to environmentally responsible building practices. This eco-friendly material not only benefits the environment but also enhances the overall quality and sustainability of our built environment.
Feasibility study on conversion of biowaste of lemon peel into carbon electrode for supercapacitor using ZnCl2 as an activating agent
Authors: Michael M. S. , Surya K. 
Published: August 2024

AbstractHere, we describe the analysis of the capacitive performance of activated carbon materials derived from the biowaste of lemon. Lemon peel discarded by restaurants after juice extraction is carbonized at 400 0C followed by chemical activation using ZnCl2. The porosity of carbon materials is tailored by varying activation conditions, such as the mass ratio of carbonized lemon peel and ZnCl2, duration of heating, and temperature. The Brunauer–Emmett– Teller (BET) surface area and pore volume of carbon materials prepared at different activating conditions range from 1380 to 2120 m2g−1 and 0.38 to 0.69 cm3 g−1 respectively. The derived carbon materials are amorphous indicated by the broad peaks in the XRD pattern as well as disordered structure of the carbon materials is revealed by the Raman spectroscopic analysis. The systematic analysis of capacitive performance of activated carbons by employing electrochemical techniques like Cyclic Voltammetry (CV), Galvanostatic charge/Discharge (GCD) cycles, and electrochemical impedance spectroscopy (EIS) in acidic (H2SO4) and alkaline (KOH) media indicates that optimum condition for activation of lemon peel is 600 °C for 60 min with 1:1 mass ratio of carbonized lemon peel and ZnCl2. The superior performance of (ALP-600) is attributed to its high surface area and well-connected hierarchical porous structure. The tiny hump at ~ 0.2 V in CV might be due to the pseudocapacitive nature of oxygen functional groups indicated by FTIR. ALP-600 exhibits the highest specific capacitance of 180 Fg−1 and retains 99.7% of its initial capacitance after 5000 cycles in the acidic electrolyte. The maximum capacitance achieved with ALP-600 symmetric cell in CR2032 coin cell configuration is 0.90F.
An accurate identification and spatial characterization method for the development degree of preferential flow paths in water-flooded reservoir
Authors: Fu Hongtao , Song Kaoping , Ma Zilin , Zhao Yu , Liang Lihao , Guo Hu 
Published: August 2024

AbstractWater flooding is one of the most important methods for oil field development, It accounts for more then 70% of China's crude oil production. However, in the progress of water flooding, preferential flow paths often formed between oil and water wells, which seriously restricts production rate. How to effectively identify the preferential flow paths has become the key to improving the effect of water flooding. In this paper, to solve the problem of difficult identification of preferential flow paths in reservoirs, through the change of core seepage law with high pore volume water flooding experiment, parameters such as multiple of water flux, change value of permeability, and water saturation were selected for analysis. The weight coefficient for each parameter was determined by the variation coefficient method of objective weight. Subsequently, a comprehensive reservoir identification index was obtained by weighting each parameter, which was used to describe the development degree of the preferential flow paths. Finally, quantitative criteria of preferential flow paths were given. The spatial characterization of preferential flow paths was realized by post processing of the Eclipse software. The new method for identifying preferential flow paths fully considers the changes in physical properties and fluid mobility of water-flooded reservoirs. The results of the new applied to a typical water-flooded reservoir in the Bohai Bay Basin show that the preferential flow paths calculated by the new method were highly consistent with the judgment results of tracers. It can accurately and quickly identify the preferential flow paths. This study provides a scientific basis for adjusting measures of water-flooded reservoirs to further enhance oil recovery. Moreover, the new method holds broader prospects for application in the field of porous media transport.
Shared Micro-mobility Market Disturbances: the Polish Bike Sharing Market in Light of Z-score Analysis
Authors: Bieliński Tomasz , Ważna Agnieszka B. , Antonowicz Paweł 
Published: August 2024

AbstractUrban transportation has changed dramatically in the recent years through the large scale implementation of shared micro-mobility services, especially bike sharing systems (BSS) and electric scooter sharing (ESS). The COVID-19 pandemic brought further changes and uncertainty to this turbulent business environment. In 2020, the major BSS operator in Poland filed for bankruptcy claiming that its problems arise from the COVID-19 pandemic. Market reports and media speculated that BSS business, despite being publicly financed, and considered to be a of part of public transportation system, could be unsustainable in face of the competition from ESS. We used Z‑score analysis to investigate if bike sharing systems operators’ problems began before or during the COVID-19 pandemic and large scale development of ESS. Our study focuses on the Nextbike company, which held a dominant stake in the Polish BSS market. It also covers two other major Polish operators and includes a German operator for comparative analysis. To complement the quantitative findings from z‑score analysis, we have also interviewed representatives of major stakeholders, which deepened our understanding of BSS problems. The results of our research indicate that although the market was affected by the COVID-19 pandemic and growing scooter-sharing competition, the problems of the largest BSS operator were specific to this company, and the entire market was not under the risk of failure.
A user guide of CART and random forests with applications in FinTech and InsurTech
Authors: Chen Yongzhao , Cheung Ka Chun , Sun Ross Zhengyao , Yam Sheung Chi Phillip 
Published: August 2024

AbstractIn the realm of financial data analytics, machine learning techniques, particularly classification and regression trees (CARTs) and random forests, have shown remarkable efficiency. This article serves as a user guide for these methods, with an emphasis on their applicability and effectiveness in analyzing datasets in FinTech and InsurTech. In particular, we present several numerical examples and empirical studies, and demonstrate their superiority in handling data with a variety of input features, offering insights into their potential applications in the industries.
Widespread service fragmentation for patients and families with tuberous sclerosis complex (TSC) in the Republic of Ireland
Authors: Vasseghi M. , Behan C. , Connolly A. , Cunningham D. , Dempsey E. , Flynn C. , Galvin M. , Griffin G. , Moloney P. , Murphy M. , Owen Y. , O’Malley S. , O’Rourke G. , O’Sullivan O. , Doherty C. P. 
Published: August 2024

Abstract
Background
Tuberous sclerosis complex (TSC) is a rare approximate 1:6000 birth incidence, a genetic disease with a wide variability of physical and neuropsychiatric symptoms. Patients require lifelong care from multiple healthcare specialities, for which International and United Kingdom (UK) TSC consensus recommendations exist. Personalised care delivered by a centralised coordinated team of TSC experts is recommended. There is no such service for the estimated 600 TSC patients in the Republic of Ireland (ROI) and there is a paucity of information regarding the healthcare of this group.

Purpose
Evaluate the baseline care of patients with TSC attending epilepsy services in the Republic of Ireland (ROI) against UK TSC consensus recommendations.

Methods
Patients with a diagnosis of TSC attending 12 adult and paediatric epilepsy centres in the ROI were identified. Clinical audits measured the baseline care of a subset of these patients against UK, TSC clinical recommendations. Data was anonymised and analysed at Trinity College Dublin.

Results
One hundred thirty-five TSC patients attending twelve epilepsy centres were identified. Adults (n = 67) paediatric (n = 68). The care of 83 patients was audited (n = 63 ≥ 18 years) and (n = 20 < 18 years). Many baseline tests were completed, however, they required intra or interhospital referral. Care appears fragmented and there was no evidence of formal disease surveillance plans.

Conclusions
The number of TSC patients attending epilepsy services is lower than expected (n = 135). Specialist services and treatments for TSC are available through informal referral pathways. Although UK, TSC consensus baseline recommendations are roughly adhered to, care is fragmented. Increased coordination of care could benefit disease management.
The role of CEUS as problem-solving technique when abdominal CT or MRI are inconclusive
Authors: Blandino Antonino Andrea , Giangrande Davide , Cannella Roberto , Bartolotta Tommaso Vincenzo 
Published: August 2024

Abstract
Purpose
To evaluate the role of CEUS in the characterization of abdominal lesions compared to CT and MRI and whether it could be “problem-solving” when CT and/or MRI are inconclusive or contraindicated.

Methods
A retrospective study was conducted on 39 patients (22 males; mean age: 64 years) with one or more abdominal focal lesions (total: 41; mean diameter: 2.9 cm) who underwent CEUS, had already undergone CT/MRI without a definitive diagnosis or had not undergone them due to contraindications. The frequency, out of the total lesions included, in which CEUS was problem-solving, confirmatory or inconclusive was evaluated.

Results
CEUS proved to be problem-solving for 20/41 (48.8%) lesions, confirmatory for 17/41 (41.5%) lesions and inconclusive for 4/41 (9.7%) lesions. Including problem-solving and confirmatory diagnosis, CEUS correctly identified 24/27 (88.9%) liver lesions, 11/11 (100%) kidney lesions, a gallbladder and a pancreatic lesion, while it did not provide useful information for 4/41 (9.7%) lesions, specifically three liver lesions and a testicular one.

Conclusions
CEUS is a promising technique when CT and/or MRI are inconclusive or contraindicated and to increase the radiologist’s diagnostic confidence.
The role of the adenylate kinase 5 gene in various diseases and cancer
Authors: Siddiqui M. Sarim , Shahi Mehdi H. , Castresana Javier S. 
Published: August 2024

Abstract
Adenylate kinases (AKs) are important enzymes involved in cellular energy metabolism. Among AKs, AK5 (adenylate kinase 5), a cytosolic protein, is emerging as a significant contributor to various diseases and cellular processes. This comprehensive review integrates findings from various research groups on AK5 since its discovery, shedding light on its multifaceted roles in nucleotide metabolism, energy regulation, and cellular differentiation. We investigate its implications in a spectrum of diseases, including autoimmune encephalitis, epilepsy, neurodegenerative disorders such as Alzheimer’s and Parkinson’s, diabetes, lower extremity arterial disease, celiac disease, and various cancers. Notably, AK5’s expression levels and methylation status have been associated with cancer progression and patient outcomes, indicating its potential as a prognostic indicator. Furthermore, AK5 is implicated in regulating cellular processes in breast cancer, gastric cancer, colorectal carcinoma, prostate cancer, and colon adenocarcinoma, suggesting its relevance across different cancer types. However, a limitation lies in the need for more robust clinical validation and a deeper understanding of AK5’s precise mechanisms in disease pathogenesis, despite its association with various pathophysiological conditions. Nonetheless, AK5 holds promise as a therapeutic target, with emerging evidence suggesting its potential in therapy development.
Autonomy Through Allotment: Political Strategies of the Ottawa Tribe in Indian Territory, 1870–1892
Authors: Dry David 
Published: August 2024

AbstractThe late nineteenth-century policy of allotting tribal lands into individually owned tracts is appropriately interpreted as a destructive federal effort to expropriate Native land and eliminate tribal identities. The Ottawa Tribe in Indian Territory, however, had divergent objectives in supporting allotment. This article argues the Ottawa advocated for allotment and U.S. citizenship to escape intrusive federal control over their lands and resources. Although they embraced policies aimed at eliminating tribal existence, the Ottawa rejected the intentions behind those policies, and instead, they drew on long-established community attributes of mobility and interconnection with outsiders to resituate their nation within American society. By centering Ottawa perspectives, this article disrupts progressive narratives that denote the pursuit of U.S. citizenship as an effort to secure equal inclusion. It underscores U.S. citizenship and allotment as tools of settler colonial domination and demonstrates how the Ottawa subversively deployed U.S. citizenship and private property rights to combat colonial administration and maintain tribal sovereignty. Examining a policy often glossed over as invariably imposed on Native nations, this article underscores the necessity of analyzing Native community dynamics and political strategies to understand the implementation and impact of allotment.
Probable Concretions Observed in the Shenandoah Formation of Jezero Crater, Mars and Comparison With Terrestrial Analogs
Authors: Kalucha H. , Broz A. , Randazzo N. , Aramendia J. , Madariaga J. M. , Garczynski B. , Lanza N. , Mandon L. , Fouchet T. , Catling D. C. , Fairén A. G. , Kivrak L. , Gasda P. J. , Núñez J. I. , Cloutis E. , Hand K. P. , Rice J. W. , Fischer W. W. , Maurice S. , Wiens R. C. 
Published: August 2024

AbstractThe Mars 2020 Perseverance Rover imaged diagenetic textural features in four separate sedimentary units in its exploration of the 25‐m‐thick Shenandoah formation at Jezero Crater, Mars, that we interpreted as probable concretions. These concretions were most abundant in the Hogwallow Flats member of the Shenandoah formation and were restricted to the light‐toned, platy, sulfur‐cemented bedrock at outcrop surfaces, whereas the finely laminated, darker toned, mottled and deformed strata lack concretions. The concretions also had a wide range of morphologies including concentric, oblate, urn, and spheroidal shaped forms that were not clustered, and ranged in size from ∼1 to 16 mm with a median of 2.65 mm. The elemental composition of the concretions compared to the bedrock had greater abundance of magnesium and calcium salts, silicates, and possibly hematite. We compared these Jezero Crater concretions to the geochemistry of concretions from previously published studies and from two new terrestrial analog sites (Gallup Formation, New Mexico and Torrey Pines, California). In addition, we measured organic carbon content of three terrestrial sedimentary analogs of increasing age that contain concretions (Torrey Pines (Pleistocene), Gallup Formation (∼89 Ma), and Moodies Group (∼3.2 Ga)). All measured concretions contained significant concentrations of organic carbon with the maximum organic carbon content (∼2 wt. % Total organic carbon) found in the Moodies Group concretions. Organic carbon abundances in terrestrial concretions was controlled more by the formation mechanism and relative timing of concretion development rather than deposit age. These findings suggested that concretions at Jezero Crater reflect local sites of enhanced biosignature preservation potential.
A wearable, rapidly manufacturable, stability-enhancing microneedle patch for closed-loop diabetes management
Authors: Liu Yiqun , Yang Li , Cui Yue 
Published: August 2024

AbstractThe development of a wearable, easy-to-fabricate, and stable intelligent minisystem is highly desired for the closed-loop management of diabetes. Conventional systems always suffer from large size, high cost, low stability, or complex fabrication. Here, we show for the first time a wearable, rapidly manufacturable, stability-enhancing microneedle patch for diabetes management. The patch consists of a graphene composite ink-printed sensor on hollow microneedles, a polyethylene glycol (PEG)-functionalized electroosmotic micropump integrated with the microneedles, and a printed circuit board for precise and intelligent control of the sensor and pump to detect interstitial glucose and deliver insulin through the hollow channels. Via synthesizing and printing the graphene composite ink, the sensor fabrication process is fast and the sensing electrodes are stable. The PEG functionalization enables the micropump a significantly higher stability in delivering insulin, extending its lifetime from days to weeks. The patch successfully demonstrated excellent blood glucose control in diabetic rats. This work may introduce a new paradigm for building new closed-loop systems and shows great promise for widespread use in patients with diabetes.
Recruitment of Cdc48 to chloroplasts by a UBX-domain protein in chloroplast-associated protein degradation
Authors: Li Na , Jarvis R. Paul 
Published: August 2024

AbstractThe translocon at the outer chloroplast membrane (TOC) is the gateway for chloroplast protein import and so is vital for photosynthetic establishment and plant growth. Chloroplast-associated protein degradation (CHLORAD) is a ubiquitin-dependent proteolytic system that regulates TOC. In CHLORAD, cytosolic Cdc48 provides motive force for the retrotranslocation of ubiquitinated TOC proteins to the cytosol but how Cdc48 is recruited is unknown. Here, we identify plant UBX-domain protein PUX10 as a component of the CHLORAD machinery. We show that PUX10 is an integral chloroplast outer membrane protein that projects UBX and ubiquitin-associated domains into the cytosol. It interacts with Cdc48 via its UBX domain, bringing it to the chloroplast surface, and with ubiquitinated TOC proteins via its ubiquitin-associated domain. Genetic analyses in Arabidopsis revealed a requirement for PUX10 during CHLORAD-mediated regulation of TOC function and plant development. Thus, PUX10 coordinates ubiquitination and retrotranslocation activities of CHLORAD to enable efficient TOC turnover.
Causal effect of video gaming on mental well-being in Japan 2020–2022
Authors: Egami Hiroyuki , Rahman Md. Shafiur , Yamamoto Tsuyoshi , Egami Chihiro , Wakabayashi Takahisa 
Published: August 2024

AbstractThe widespread use of video games has raised concerns about their potential negative impact on mental well-being. Nevertheless, the empirical evidence supporting this notion is largely based on correlational studies, warranting further investigation into the causal relationship. Here we identify the causal effect of video gaming on mental well-being in Japan (2020–2022) using game console lotteries as a natural experiment. Employing approaches designed for causal inference on survey data (n = 97,602), we found that game console ownership, along with increased game play, improved mental well-being. The console ownership reduced psychological distress and improved life satisfaction by 0.1–0.6 standard deviations. Furthermore, a causal forest machine learning algorithm revealed divergent impacts between different types of console, with one showing smaller benefits for adolescents and females while the other showed larger benefits for adolescents. These findings highlight the complex impact of digital media on mental well-being and the importance of considering differential screen time effects.
Bioinformatics analysis to disclose shared molecular mechanisms between type-2 diabetes and clear-cell renal-cell carcinoma, and therapeutic indications
Authors: Ahmmed Reaz , Hossen Md. Bayazid , Ajadee Alvira , Mahmud Sabkat , Ali Md. Ahad , Mollah Md. Manir Hossain , Reza Md. Selim , Islam Mohammad Amirul , Mollah Md. Nurul Haque 
Published: August 2024

AbstractType 2 diabetes (T2D) and Clear-cell renal cell carcinoma (ccRCC) are both complicated diseases which incidence rates gradually increasing. Population based studies show that severity of ccRCC might be associated with T2D. However, so far, no researcher yet investigated about the molecular mechanisms of their association. This study explored T2D and ccRCC causing shared key genes (sKGs) from multiple transcriptomics profiles to investigate their common pathogenetic processes and associated drug molecules. We identified 259 shared differentially expressed genes (sDEGs) that can separate both T2D and ccRCC patients from control samples. Local correlation analysis based on the expressions of sDEGs indicated significant association between T2D and ccRCC. Then ten sDEGs (CDC42, SCARB1, GOT2, CXCL8, FN1, IL1B, JUN, TLR2, TLR4, and VIM) were selected as the sKGs through the protein–protein interaction (PPI) network analysis. These sKGs were found significantly associated with different CpG sites of DNA methylation that might be the cause of ccRCC. The sKGs-set enrichment analysis with Gene Ontology (GO) terms and KEGG pathways revealed some crucial shared molecular functions, biological process, cellular components and KEGG pathways that might be associated with development of both T2D and ccRCC. The regulatory network analysis of sKGs identified six post-transcriptional regulators (hsa-mir-93-5p, hsa-mir-203a-3p, hsa-mir-204-5p, hsa-mir-335-5p, hsa-mir-26b-5p, and hsa-mir-1-3p) and five transcriptional regulators (YY1, FOXL1, FOXC1, NR2F1 and GATA2) of sKGs. Finally, sKGs-guided top-ranked three repurposable drug molecules (Digoxin, Imatinib, and Dovitinib) were recommended as the common treatment for both T2D and ccRCC by molecular docking and ADME/T analysis. Therefore, the results of this study may be useful for diagnosis and therapies of ccRCC patients who are also suffering from T2D.