bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary pulmonary rhabdomyosarcoma in children: Report of three cases with review of literature
Authors: Lokesh Kadabur Nagendrappa , Premalata Chennagiri S. , Kumari B.S. Aruna , Appaji L 
Published: June 2013

AbstractPrimary pulmonary rhabdomyosarcoma in children is rare. Three children aged three, nine and three years were evaluated for abnormal shadows on radiological examination with pneumothorax in two cases. Resection and histopathological examination revealed embryonal rhabdomyosarcoma in all and cystic malformation in first case. All the three children were treated with surgery and first two received adjuvant chemotherapy. The disease free duration was 160 months, 19 months and seven months respectively. The literature on primary pulmonary rhabdomyosarcoma in children was reviewed.
A Novel Combinatorial Therapy With Pulp Stem Cells and Granulocyte Colony-Stimulating Factor for Total Pulp Regeneration
Authors: Iohara Koichiro , Murakami Masashi , Takeuchi Norio , Osako Yohei , Ito Masataka , Ishizaka Ryo , Utunomiya Shinji , Nakamura Hiroshi , Matsushita Kenji , Nakashima Misako 
Published: June 2013

AbstractTreatment of deep caries with pulpitis is a major challenge in dentistry. Stem cell therapy represents a potential strategy to regenerate the dentin-pulp complex, enabling conservation and restoration of teeth. The objective of this study was to assess the efficacy and safety of pulp stem cell transplantation as a prelude for the impending clinical trials. Clinical-grade pulp stem cells were isolated and expanded according to good manufacturing practice conditions. The absence of contamination, abnormalities/aberrations in karyotype, and tumor formation after transplantation in an immunodeficient mouse ensured excellent quality control. After autologous transplantation of pulp stem cells with granulocyte-colony stimulating factor (G-CSF) in a dog pulpectomized tooth, regenerated pulp tissue including vasculature and innervation completely filled in the root canal, and regenerated dentin was formed in the coronal part and prevented microleakage up to day 180. Transplantation of pulp stem cells with G-CSF yielded a significantly larger amount of regenerated dentin-pulp complex compared with transplantation of G-CSF or stem cells alone. Also noteworthy was the reduction in the number of inflammatory cells and apoptotic cells and the significant increase in neurite outgrowth compared with results without G-CSF. The transplanted stem cells expressed angiogenic/neurotrophic factors. It is significant that G-CSF together with conditioned medium of pulp stem cells stimulated cell migration and neurite outgrowth, prevented cell death, and promoted immunosuppression in vitro. Furthermore, there was no evidence of toxicity or adverse events. In conclusion, the combinatorial trophic effects of pulp stem cells and G-CSF are of immediate utility for pulp/dentin regeneration, demonstrating the prerequisites of safety and efficacy critical for clinical applications.
Concise Review: Endothelial Stem and Progenitor Cells and Their Habitats
Authors: Goligorsky Michael S. , Salven Petri 
Published: June 2013

Abstract
Recent studies on the stem cell origins of regenerating tissues have provided solid evidence in support of the role of the resident cells, rather than bone marrow-derived or transplanted stem cells, in restoring tissue architecture after an injury. This is also true for endothelial stem and progenitor cells: local pools exist in the vascular wall, and those cells are the primary drivers of vascular regeneration. This paradigm shift offers an opportunity to rethink and refine our understanding of the multiple therapeutic effects of transplanted endothelial progenitor cells, focusing on their secretome, sheddome, intercellular communicational routes, and other potential ways to rejuvenate and replenish the pool of resident cells. The dynamics of vascular wall resident cells, at least in the adipose tissue, may shed light on the origins of other cells present in the vascular wall—pericytes and mesenchymal stem cells. The fate of these cells in aging and disease awaits elucidation.
Aliança estratégica: papel dos estrategistas e das propriedades estruturas do campo organizacional
Authors: Walter Silvana Anita 
Published: June 2013

Este estudo emprega a abordagem de estratégia como prática – para analisar a atuação de diferentes estrategistas na prática de aliança estratégica - aliada à teoria da estruturação - para verificar se as propriedades estruturais (regras e recursos) do campo organizacional guiam a adoção da aliança estratégica. Realizou-se o estudo de caso da Sooro Concentrado Indústria de Produtos Lácteos Ltda. com uma abordagem qualitativa de caráter descritivo----interpretativa. A perspectiva temporal é transversal com avaliação longitudinal de 2002 a 2011. Para a coleta de dados, empregaram-se entrevistas com questões abertas, observação não participante e análise documental. Para análise dos dados, utilizou-se a análise de conteúdo. Em relação aos estrategistas, notou-se que tanto os internos – como os sócios fundadores –, quanto os externos – como a parceira – atuam na aliança estratégica. Notou-se, também, que as ações dessa prática estratégica são orientadas por propriedades estruturais do campo organizacional, como os recursos de capital humano e de imagem e reputação positivos, assim como a regra de aliada da parceira. Conclui-se que a adoção da prática de aliança estratégica envolveu aspectos de diferentes âmbitos: organização e campo organizacional. Nota-se que a abordagem de estratégia como prática e a teoria da estruturação podem ser integradas como forma de analisar alianças estratégicas.
Competência estratégica em uma organização do setor metal- mecânico
Authors: Mioranza Gustavo , Ganzer Paula Patrícia , Muraro Renata , Olea Pelayo Munhoz , Dorion Eric 
Published: June 2013

O processo de estudo de competências é utilizado em áreas do conhecimento para analisar os resultados das organizações, de modo geral e de qualquer natureza, com vista a perceber e interpretar a realidade. A pesquisa teve por objetivo identificar como a gestão de competências pode contribuir para o desempenho organizacional. Quanto à natureza da pesquisa, classifica-se em qualitativa aplicada, a partir da revisão da literatura baseada em referências teóricas; a estratégia de abordagem utilizada foi o estudo de caso em uma indústria do setor metal-mecânico, classificando a pesquisa como exploratória a partir de entrevistas em profundidade. A coleta de dados aconteceu por meio de entrevistas individuais em profundidade, adotando-se uma abordagem estruturada, com a aplicação de um roteiro básico de questões, desenvolvido a partir da literatura (JAVIDAN, 1998), aplicado aos colaboradores da empresa pesquisada. A análise dos dados ocorreu por meio de análise de conteúdo das entrevistas, observando-se a frequência de termos mais citados pelos entrevistados. A pesquisa assinala a importância das competências em entender e interpretar a vida profissional de cada indivíduo e o local em que esse indivíduo está inserido. Em um comparativo das abordagens de competência, identificou-se a contribuição das experiências passadas, das interações sociais, dos símbolos e significados dos momentos de dificuldade nas alterações ou consolidações das competências e sua gestão. Concluiu-se que haverá interferência no desempenho organizacional, a partir de seus elementos cognitivos, fatores emocionais, simbólicos e funcionais e da forma como os indivíduos interagem e aprendem entre si, da forma como suas competências se encontram configuradas. As competências envolvem o que cada indivíduo realiza, pois implicam no cumprimento dos seus compromissos profissionais.
Photocatalytic Reduction of CO2 on TiO2 and Other Semiconductors
Authors: Habisreutinger Severin N. , Schmidt‐Mende Lukas , Stolarczyk Jacek K. 
Published: June 2013

AbstractRising atmospheric levels of carbon dioxide and the depletion of fossil fuel reserves raise serious concerns about the ensuing effects on the global climate and future energy supply. Utilizing the abundant solar energy to convert CO2 into fuels such as methane or methanol could address both problems simultaneously as well as provide a convenient means of energy storage. In this Review, current approaches for the heterogeneous photocatalytic reduction of CO2 on TiO2 and other metal oxide, oxynitride, sulfide, and phosphide semiconductors are presented. Research in this field is focused primarily on the development of novel nanostructured photocatalytic materials and on the investigation of the mechanism of the process, from light absorption through charge separation and transport to CO2 reduction pathways. The measures used to quantify the efficiency of the process are also discussed in detail.
Characterization and modeling of diglycidyl ether of bisphenol‐a epoxy cured with aliphatic liquid amines
Authors: Guest Nicola T. , Tilbrook David A. , Ogin Stephen L. , Smith Paul A. 
Published: June 2013

ABSTRACTThe characterization by DMA and compressive stress‐strain behavior of an epoxy resin cured with a number of liquid amines is studied in this work along with predictions of the associated properties using Group Interaction Modeling (GIM). A number of different methods are used to assign two of the input parameters for GIM, and the effect on the predictions is investigated. Excellent predictions are made for the glass transition temperature, along with good predictions for the beta transition temperature and modulus for the majority of resins tested. Predictions for the compressive yield stress and strain are less accurate, due to a number of factors, but still show reasonable correlation with the experimental data. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3130–3141, 2013
The effect of partial replacement of carbon black by carbon nanotubes on the properties of natural rubber/butadiene rubber compound
Authors: Poikelispää Minna , Das Amit , Dierkes Wilma , Vuorinen Jyrki 
Published: June 2013

ABSTRACTThe basic objective of this study is to investigate the mechanical properties of tyre tread compounds by gradual replacement of carbon black by multiwalled carbon nanotubes (MWCNTs) in a natural rubber–butadiene rubber‐based system. A rapid change in the mechanical properties is noticed even at very low concentrations of nanotubes though the total concentration of the filler is kept constant at 25 phr (parts per hundred rubber). The correlation of the bound rubber content with MWCNT loading directly supports the conclusion that MWCNTs increase the occluded rubber fraction. Transmission electron microscopy reveals a good dispersion of the MWCNT up to a certain concentration. In the presence of MWCNT, a prominent negative shift of the glass transition temperature of the compound is found. Thermal degradation behavior, aging, and swelling experiments were also carried out to understand the resulting effect of the incorporation of MWCNT in the rubber matrix. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3153–3160, 2013
Dynamic mechanical thermal analysis of biocomposites based on PLA and PHBV—A comparative study to PP counterparts
Authors: Adam Jaszkiewicz , Korneliusz Bledzki Andrzej , Agnieszka Meljon 
Published: June 2013

ABSTRACTThe primary objective of this study was the investigation of thermo‐mechanical behavior of cellulosic fiber reinforced polylactid (PLA) and poly(3‐hydroxybutyrate‐co‐3‐hydroxyvalerate) (PHBV) biopolymers. Both PLA and PHBV were processed with 30 wt % of cellulosic fibers; moreover, to improve the processability and mechanical performance, PHBV was previously blended with 30% by weight poly(butylene adipate‐co‐butylene terephthalate) (PBAT). Secondary target was the comparison of the obtained results to natural fiber reinforced polypropylene (PP) composites reinforced with exact the same fibers and processed by using identical techniques. For validation the thermo‐mechanical properties, a dynamic mechanical thermal analysis (DMTA) was applied. Storage modulus (E′), loss modulus (E″), and loss factor (tan δ) were determined. The DMTA results indicate decreased polymer chain motion with resulting improvement of stiffness expressed by the storage modulus. Finally, the effectiveness of fiber on the moduli was investigated. The C coefficient differs in dependence on fiber type, use of coupling agent, and the reference temperature in glassy state. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3175–3183, 2013
Phosphatidylinositol‐3,4,5‐trisphosphate: Tool of choice for class I PI 3‐kinases
Authors: Salamon Rachel Schnur , Backer Jonathan M. 
Published: June 2013

Class I PI 3‐kinases signal by producing the signaling lipid phosphatidylinositol(3,4,5) trisphosphate, which in turn acts by recruiting downstream effectors that contain specific lipid‐binding domains. The class I PI 3‐kinases comprise four distinct catalytic subunits linked to one of seven different regulatory subunits. All the class I PI 3‐kinases produce the same signaling lipid, PIP3, and the different isoforms have overlapping expression patterns and are coupled to overlapping sets of upstream activators. Nonetheless, studies in cultured cells and in animals have demonstrated that the different isoforms are coupled to distinct ranges of downstream responses. This review focuses on the mechanisms by which the production of a common product, PIP3, can produce isoform‐specific signaling by PI 3‐kinases.Editor's suggested further reading in BioEssays: Phosphatidylinositol 4,5‐bisphosphate: Targeted production and signaling AbstractHow does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity? Abstract
Catalytic synthesis and antioxidant activity of sulfated polysaccharide from Momordica charantia L.
Authors: Liu Xin , Chen Tong , Hu Yan , Li Kexin , Yan Liushui 
Published: June 2013

ABSTRACTSulfated derivatives of polysaccharide from Momordica charantia L. (MCPS) with different degree of sulfation (DS) were synthesized by chlorosulfonic acid method with ionic liquids as solvent. Fourier transform infrared spectra and 13C nuclear magnetic resonance spectra indicated that C‐6 substitution was predominant in MCPS compared with the C‐2 position. Compared with the native polysaccharide from Momordica charantia L. (MCP), MCPS exhibited more excellent antioxidant activities in vitro, which indicated that sulfated modification could enhance antioxidant activities of MCP. Furthermore, high DS and moderate molecular weight could improve the antioxidant activities of polysaccharide. © 2013 Wiley Periodicals, Inc. Biopolymers 101: 210–215, 2014.
Identification of the absorptive constituents and their metabolites in vivo of Puerariae Lobatae Radix decoction orally administered in WZS‐miniature pigs by HPLC‐ESI‐Q‐TOFMS
Authors: Zhou Qi‐Le , Wang Ying‐Feng , Yang Dong‐Hui , Xu Feng , Zhao Xin , Zhang Lei , Liang Jing , Yang Xiu‐Wei 
Published: June 2013

ABSTRACTIn this study, the technique of high‐performance liquid chromatography coupled with electrospray ionization quadrupole time‐of‐flight mass spectrometry (HPLC‐ESI‐Q‐TOFMS) was used to analyze and identify the absorptive constituents and their metabolites in drug‐containing urine of Wuzhishan (WZS)‐miniature pigs administered with Puerariae Lobatae Radix (PLR) decoction. With the accurate mass measurements (<5 ppm) and effective MS2 fragment ions, 96 compounds, including eight original constituents and 88 metabolites, were identified from the drug‐containing urine. Among these, 64 metabolites were new ones and their structures can be categorized into five types: isoflavones, puerols, O‐desmethylangolensins, equols and isoflavanones. In particular, puerol‐type constituents in PLR were first proved to be absorptive in vivo. Meanwhile, the metabolic pathways of PLR in vivo were investigated. On the basis of relative content of the identified compounds, 13 major metabolites accounting for approximately 50% of the contents, as well as their corresponding 12 prototype compounds, were determined as the major original absorptive constituents and metabolites of PLR in vivo. The HPLC‐ESI‐Q‐TOFMS technique proved to be powerful for characterizing the chemical constituents from the complicated traditional Chinese medicine matrices in this research. Copyright © 2013 John Wiley & Sons, Ltd.
Emergency cardiac surgery during transfemoral and transapical transcatheter aortic valve implantation: Incidence, reasons, management, and outcome of 411 patients from a single center
Authors: Griese Daniel P. , Reents Wilko , Kerber Sebastian , Diegeler Anno , Babin‐Ebell Jörg 
Published: June 2013

Objectives and BackgroundTranscatheter aortic valve implantation (TAVI) is increasingly performed in high‐risk patients with severe aortic valve stenosis. Incidence and impact of emergency cardiac surgery (ECS) during TAVI is unclear.Methods and ResultsTwo‐hundred twenty one transapical (TA) and 190 transfemoral (TF) TAVIs were performed at our hospital between 01/2009 and 12/2012. Twenty patients (4.9%) required ECS, more frequently in the TF‐ (n = 11; 5.8%) than in the TA‐group (n = 9; 4.1%; P = 0.017). ECS‐cases were evenly distributed throughout the 4 years. Baseline characteristics of the ECS‐patients were not different from the non‐ECS‐patients. Reasons were acute cardiac failure, coronary obstruction, annular rupture, valve migration, right‐ and left‐ventricular perforation, severe paravalvular leakage, aortic dissection, and mitral valve damage. Surgical intervention consisted of peripheral CPB, switch to TA, thoracotomy and suture of perforated cardiac chambers and conventional aortic valve replacement with concomitant repair of associated cardiovascular injury. Thirty‐day mortality was 35.0%, and 55.0% could be salvaged to hospital discharge. Kaplan–Meier 1‐year survival curves were significantly impaired for patients requiring ECS (TF: P < 0.0001, HR 8.716; TA: P = 0.013, HR 2.813).ConclusionsLife‐threatening complications requiring bail‐out ECS occur in a substantial proportion during TAVI. ECS dramatically affects early and late outcome after TAVI. Under optimal conditions more than half of the ECS‐patients can be salvaged. With the current technology of THV‐systems ECS should be an integral part of the logistic conditions surrounding TAVI and is far from being futile in this patient population. © 2013 Wiley Periodicals, Inc.
Patent foramen ovale closure with the gore septal occluder
Authors: Thomson John D. , Hildick‐Smith David , Clift Paul , Morgan Gareth , Daniels Matthew , Henderson Robert , Spence Mark S. , Mahadevan Vaikom S. , Crossland David , Ormerod Oliver 
Published: June 2013

ObjectivesTo report procedural outcome and short‐term follow‐up data for the Gore septal occluder (GSO), a new device for closure of patent foramen ovale (PFO).BackgroundTranscatheter closure of PFO is an established treatment modality but no current device provides a perfect solution. The GSO has a number of design features, which make it potentially attractive for closure of defects in the atrial septum.MethodsData from 9 centers in the United Kingdom implanting the GSO device, submitted to an electronic registry for evaluation.ResultsTwo hundred twenty‐nine patients undergoing PFO closure from June 2011 to October 2012 were included. Indications for closure were secondary prevention of paradoxical cerebral emboli (83.4%), migraine (2.1%), platypnoea orthodeoxia (3.9%), and other (10.5%). Median PFO size was 8 mm and 34 and 39%, respectively, had long tunnel anatomy or atrial septal aneurysms. A GSO was successfully implanted in all cases. A single device was used in 98% but in 4 patients the initial device was removed and a second device required. Procedural complications occurred in 3% and later complications (e.g., atrial fibrillation, atrial ectopics, and device thrombus) in 5.7% of cases. All patients have undergone clinical and echocardiographic follow‐up and all devices remain in position. Early bubble studies (median 0 months) with Valsalva maneuver in 67.2% were negative in 89%.ConclusionsThe GSO is an effective occlusion device for closure of PFO of all types. Longer‐term follow‐up particularly to document later closure rates are required. © 2013 Wiley Periodicals, Inc.
Microemulsion‐Assisted Preparation of a Mesoporous Ferrihydrite/SiO2 Composite for the Efficient Removal of Formaldehyde from Air
Authors: Xu Zhihua , Yu Jiaguo , Xiao Wei 
Published: June 2013

AbstractMesoporous ferrihydrite/SiO2 composites were synthesized according to a water‐in‐oil microemulsion method and characterized by X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, thermogravimetry, nitrogen‐adsorption/desorption, and by X‐ray photoelectron spectroscopy. The as‐prepared porous ferrihydrite/SiO2 composites showed an excellent adsorption performance for formaldehyde (HCHO) removal from indoor air at ambient temperature. It was found that the aging time during the synthesis had a significant impact on the pore structure, surface area, and HCHO adsorption of these materials. The ferrihydrite/SiO2 composite that was aged for 3 h in the presence of tetraethyl orthosilicate (TEOS) exhibited a relatively high HCHO adsorption capacity, as well as good recyclability, which was attributed to a relatively large BET surface area, optimal pore size, a suitable Si/Fe atomic ratio, and a synergistic effect between ferrihydrite and SiO2. This work not only demonstrates that porous ferrihydrite/SiO2 composites can act as an efficient adsorbent toward HCHO, but suggests a new route for the rational design of cost‐effective and environmentally benign adsorbents with high performance for indoor air purification.
Formation of a Thymine‐HgII‐Thymine Metal‐Mediated DNA Base Pair: Proposal and Theoretical Calculation of the Reaction Pathway
Authors: Šebera Jakub , Burda Jaroslav , Straka Michal , Ono Akira , Kojima Chojiro , Tanaka Yoshiyuki , Sychrovský Vladimír 
Published: June 2013

AbstractA reaction mechanism that describes the substitution of two imino protons in a thymine:thymine (T:T) mismatched DNA base pair with a HgII ion, which results in the formation of a (T)N3‐HgII‐N3(T) metal‐mediated base pair was proposed and calculated. The mechanism assumes two key steps: The formation of the first HgIIN3(T) bond is triggered by deprotonation of the imino N3 atom in thymine with a hydroxo ligand on the HgII ion. The formation of the second HgIIN3(T) bond proceeds through water‐assisted tautomerization of the remaining, metal‐nonbonded thymine base or through thymine deprotonation with a hydroxo ligand of the HgII ion already coordinated to the thymine base. The thermodynamic parameters ΔGR=−9.5 kcal mol−1, ΔHR=−4.7 kcal mol−1, and ΔSR=16.0 cal mol−1 K−1 calculated with the ONIOM (B3LYP:BP86) method for the reaction agreed well with the isothermal titration calorimetric (ITC) measurements by Torigoe et al. [H. Torigoe, A. Ono, T. Kozasa, Chem. Eur. J. 2010, 16, 13218–13225]. The peculiar positive reaction entropy measured previously was due to both dehydration of the metal and the change in chemical bonding. The mercury reactant in the theoretical model contained one hydroxo ligand in accord with the experimental pKa value of 3.6 known for an aqua ligand of a HgII center. The chemical modification of T:T mismatched to the T‐HgII‐T metal‐mediated base pair was modeled for the middle base pair within a trinucleotide B‐DNA duplex, which ensured complete dehydration of the HgII ion during the reaction.