bluuebunny/crossref_metadata_2025_split huggingface dataset:
Radiographic Identification of the Anterior and Posterior Root Attachments of the Medial and Lateral Menisci
Authors: James Evan W. , LaPrade Christopher M. , Ellman Michael B. , Wijdicks Coen A. , Engebretsen Lars , LaPrade Robert F. 
Published: August 2014

Background: Anatomic root placement is necessary to restore native meniscal function during meniscal root repair. Radiographic guidelines for anatomic root placement are essential to improve the accuracy and consistency of anatomic root repair and to optimize outcomes after surgery. Purpose: To define quantitative radiographic guidelines for identification of the anterior and posterior root attachments of the medial and lateral menisci on anteroposterior (AP) and lateral radiographic views. Study Design: Descriptive laboratory study. Methods: The anterior and posterior roots of the medial and lateral menisci were identified in 12 human cadaveric specimens (average age, 51.3 years; age range, 39-65 years) and labeled using 2-mm radiopaque spheres. True AP and lateral radiographs were obtained, and 2 raters independently measured blinded radiographs in relation to pertinent landmarks and radiographic reference lines. Results: On AP radiographs, the anteromedial and posteromedial roots were, on average, 31.9 ± 5.0 mm and 36.3 ± 3.5 mm lateral to the edge of the medial tibial plateau, respectively. The anterolateral and posterolateral roots were, on average, 37.9 ± 5.2 mm and 39.3 ± 3.8 mm medial to the edge of the lateral tibial plateau, respectively. On lateral radiographs, the anteromedial and anterolateral roots were, on average, 4.8 ± 3.7 mm and 20.5 ± 4.3 mm posterior to the anterior margin of the tibial plateau, respectively. The posteromedial and posterolateral roots were, on average, 18.0 ± 2.8 mm and 19.8 ± 3.5 mm anterior to the posterior margin of the tibial plateau, respectively. The intrarater and interrater intraclass correlation coefficients (ICCs) were >0.958, demonstrating excellent reliability. Conclusion: The meniscal root attachment sites were quantitatively and reproducibly defined with respect to anatomic landmarks and superimposed radiographic reference lines. The high ICCs indicate that the measured radiographic relationships are a consistent means for evaluating meniscal root positions. Clinical Relevance: This study demonstrated consistent and reproducible radiographic guidelines for the location of the meniscal roots. These measurements may be used to assess root positions on intraoperative fluoroscopy and postoperative radiographs.
The nursing discipline and self-realization
Authors: Kristoffersen Margareth , Friberg Febe 
Published: August 2014

Background: It is obvious from literature within the nursing discipline that nursing is related to moral or moral–philosophical related ideas which are other-oriented. The socio-cultural process of change in modern society implies that more self-oriented ideas have been found to be significant. Aim: The overall aim of this article is to highlight self-oriented moral or moral–philosophical related ideas as an important part of the nursing discipline. This is achieved by (a) exploring self-realization as a significant self-oriented moral or moral–philosophical related idea based on a philosophical anthropological perspective, (b) demonstrating how moral or moral–philosophical related ideas are expressed by nurses, (c) discussing the relevance of self-realization for the nursing discipline, and (d) pointing out possible consequences for the future development of the discipline of nursing. Research design: This theoretical study draws empirical examples from interviews. Participants and research context: Data consisted of interviews with 13 nurses with varying work experience within the primary and secondary somatic and psychiatric health service, from inside as well as outside institutions. Ethical considerations: The empirical study was approved by the Norwegian Social Science Data Services. Information was given and consent was obtained from the study participants. Findings: Findings are presented in two themes: (a) other-oriented ideas and (b) self-oriented ideas. More concretely, the findings show that nurses hope to make life as good as possible for the patient and they have a wish to improve themselves as human beings, to become better persons. Discussion: The relevance of self-realization for the nursing discipline is discussed along two lines, first, by connecting nurses’ self-understanding to a horizon of identity and second, by considering what self-realization could offer. Conclusion: It is of ultimate concern for the nursing discipline to highlight self-realization connected to the positive view of freedom understood as an exercise-concept. Further identifying and articulating the contribution of self-realization to nurses and nursing practice is of particular importance.
Feline cutaneous lymphocytosis: case report and summary of the literature
Authors: Pariser Marlene S , Gram Dunbar W 
Published: August 2014

Practical relevance: Feline cutaneous lymphocytosis is a rare disease characterized by proliferation of T and/or B lymphocytes in the dermis. Although some of the clinical and histopathologic findings of this condition can overlap with cutaneous lymphoma, it is important to distinguish these entities since their treatment and clinical outcomes vary greatly. Scope: This report presents a summary of the literature on feline cutaneous lymphocytosis and describes a case of this condition which showed some unique clinical features and was successfully controlled with oral glucocorticoids.
The effects of siRNA-silenced TRPC6 on podocyte autophagy and apoptosis induced by AngII
Authors: Shengyou Yu , Li Yu 
Published: August 2014

Objective: the objective of this article is to evaluate the role of siRNA-silenced TRPC6 on podocyte autophagy and apoptosis induced by AngII. Methods: mouse podocyte cell lines were cultured in vitro. The apoptosis rates of each group were detected using flow cytometry. The expression of LC3-II protein and changes in distribution were detected by confocal laser, and the western blot protocol was employed for detection of protein expression of LC3-II. Results: AngII-injured podocyte had a significant increase in apoptosis, while silencing TRPC6 could decrease the apoptosis induced by AngII. Autophagy remarkably increased after AngII injury. While silencing TRPC6 stabilized the autophagy expression, AngII could activate the autophagy of podocyte. Autophagy-associated protein LC3-II expression increased after AngII injury. The LC3-II mRNA and the protein level could be down regulated by 3-MA. The silencing of TRPC6 could stabilize the autophagy expression. Conclusion: the data suggest that AngII can lead to podocyte injury. Autophagy may have beneficial effects in preventing the progression of proteinuria. This study provides some new clues for further exploring the occurrence of podocyte injury and the development mechanism of proteinuria.
Simultaneous First Metatarsophalangeal Joint Arthrodesis and Sesamoidectomy With a Single Dorsomedial Incision
Authors: Alshouli Mohammed T. , Lin Albert , Kadakia Anish Raj 
Published: August 2014

First metatarsophalangeal (MTP) arthrodesis is a well-accepted procedure for the treatment of end-stage hallux rigidus. Despite the excellent and predictable clinical results, the procedure does not address the metatarso-sesamoid joint complex. There has been one case report of arthritis of the metatarsal sesamoid joint as uncommon cause of post–arthrodesis hallux pain. Additionally, we have noted this complication in our practice as well despite the paucity of reported cases in the published literature. Resection of either the tibial or fibular sesamoid is an acceptable treatment for recalcitrant sesamoid pain; however, resection of both the tibial and fibular sesamoids as would be required for arthritic changes is not encouraged to prevent the risk of a cock-up toe deformity. Arthrodesis of the first MTP joint eliminates the possibility of this complication. Resection of the sesamoids following a first MTP fusion requires a separate incision with additional morbidity and risk to the medial plantar digital nerve. This second surgical intervention is not without morbidity and carries additional cast to the patient, which can be avoided if the pathology is appropriately identified preoperatively. We describe the surgical indications and novel technique for a first MTP arthrodesis and total sesamoid resection through a standard dorsomedial incision. The approach adds minimal surgical time and morbidity and eliminates the source of plantar first MTP pain that is present in a cohort of patients with hallux rigidus. Levels of Evidence: Level IV, Case Series
Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice
Authors: Ortiz-Muñoz Guadalupe , Mallavia Beñat , Bins Adriaan , Headley Mark , Krummel Matthew F. , Looney Mark R. 
Published: August 2014

Key PointsNeutrophil-platelet aggregates are dynamically formed in the lung in response to injury and are regulated by aspirin-triggered lipoxin. The therapeutic effect of aspirin in acute lung injury is in large part mediated by the production of pro-resolving lipid mediators.
On lacunary statistical boundedness
Authors: Bhardwaj Vinod K , Gupta Sandeep , Mohiuddine Syed A , Kılıçman Adem 
Published: August 2014

AbstractA new concept of lacunary statistical boundedness is introduced. It is shown that, for a given lacunary sequenceθ={kr}, a sequence{xk}is lacunary statistical bounded if and only if for ‘almost allkw.r.t.θ’, the valuesxkcoincide with those of a bounded sequence. Apart from studying various algebraic properties and computing the Köthe-Toeplitz duals of the spaceSθ(b)of all lacunary statistical bounded sequences, a decomposition theorem is also established. We characterize thoseθfor whichSθ(b)=S(b). Finally, we give a general description of inclusion between two arbitrary lacunary methods of statistical boundedness.MSC:40C05, 40A05, 46A45.
pH-responsive drug delivery system based on hollow silicon dioxide micropillars coated with polyelectrolyte multilayers
Authors: Alba María , Formentín Pilar , Ferré-Borrull Josep , Pallarès Josep , Marsal Lluís F 
Published: August 2014

Abstract
We report on the fabrication of polyelectrolyte multilayer-coated hollow silicon dioxide micropillars as pH-responsive drug delivery systems. Silicon dioxide micropillars are based on macroporous silicon formed by electrochemical etching. Due to their hollow core capable of being loaded with chemically active agents, silicon dioxide micropillars provide additional function such as drug delivery system. The polyelectrolyte multilayer was assembled by the layer-by-layer technique based on the alternative deposition of cationic and anionic polyelectrolytes. The polyelectrolyte pair poly(allylamine hydrochloride) and sodium poly(styrene sulfonate) exhibited pH-responsive properties for the loading and release of a positively charged drug doxorubicin. The drug release rate was observed to be higher at pH 5.2 compared to that at pH 7.4. Furthermore, we assessed the effect of the number of polyelectrolyte bilayers on the drug release loading and release rate. Thus, this hybrid composite could be potentially applicable as a pH-controlled system for localized drug release.
Effects of macro- versus nanoporous silicon substrates on human aortic endothelial cell behavior
Authors: Formentín Pilar , Alba María , Catalán Úrsula , Fernández-Castillejo Sara , Pallarès Josep , Solà Rosà , Marsal Lluís F 
Published: August 2014

AbstractHuman aortic endothelial cells play a key role in the pathogenesis of atherosclerosis, which is a common, progressive, and multifactorial disease that is the clinical endpoint of an inflammatory process and endothelial dysfunction. Study and development of new therapies against cardiovascular disease must be tested in vitro cell models, prior to be evaluated in vivo.To this aim, new cell culture platforms are developed that allow cells to grow and respond to their environment in a realistic manner. In this work, the cell adhesion and morphology of endothelial cells are investigated on functionalized porous silicon substrates with two different pore size configurations: macroporous and nanoporous silicon. Herein, we modified the surfaces of porous silicon substrates by aminopropyl triethoxysilane, and we studied how different pore geometries induced different cellular response in the cell morphology and adhesion. The cell growth over the surface of porous silicon becomes an attractive field, especially for medical applications. Surface properties of the biomaterial are associated with cell adhesion and as well as, with proliferation, migration and differentiation.
Prediction of remission after metabolic surgery using a novel scoring system in type 2 diabetes – a retrospective cohort study
Authors: Ugale Surendra , Gupta Neeraj , Modi Kirtikumar D , Kota Sunil K , Satwalekar Vasisht , Naik Vishwas , Swapna Modukuri , Kumar KVS Hari 
Published: August 2014

Abstract
Background
Remission of diabetes is seen in more than 60% of patients after bariatric surgery. There is extensive variability in the remission rates between different surgical procedures. We analyzed our database and aimed to develop an easy scoring system to predict the probability of diabetes remission after two surgical procedures i.e. Ileal Interposition coupled with Sleeve Gastrectomy (IISG) or Diverted Sleeve Gastrectomy (IIDSG).

Methods
In this retrospective study, we analyzed records pertaining to patients who underwent IISG (n = 46) and IIDSG (n = 29). The primary outcome measure was diabetes remission (A1c <6.5% and not requiring hypoglycemic drugs). We identified seven preoperative clinical variables (age, duration of diabetes, body mass index, micro and macrovascular complications, use of insulin and stimulated C-peptide) based on our previous reports to be included in the diabetes remission score (DRS). The DRS score (7 – 14) was compared between the patients with and without remission in both the surgery groups.

Results
Mean DRS in patients who underwent IISG was 9.2 ± 1.4. Twenty one (46%) had a remission in diabetes. DRS was significantly lower in patients with remission than patients without remission (8.1 ± 0.8 versus 10.2 ± 0.9, p < 0.0001). Mean DRS in patients who underwent IIDSG was 10.4 ± 1.3. Twenty one (72%) had a remission in diabetes. DRS was significantly lower in patients with remission than patients without remission (9.7 ± 0.8 versus 12.0 ± 0.5, p < 0.0001). Patients with a DRS ≥ 10 in IISG group and more than 12 in IIDSG group did not get into remission.

Conclusion
Preoperative DRS can be a useful tool to select the type of surgical procedure and to predict the postoperative diabetes remission.

Trial registration
NCT00834626.
Mesenchymal stem cells, not conditioned medium, contribute to kidney repair after ischemia-reperfusion injury
Authors: Xing Li , Cui Rui , Peng Lei , Ma Jing , Chen Xiao , Xie Ru-Juan , Li Bing 
Published: August 2014

Abstract
Introduction
Studies have shown that stem cells exert their therapeutic effects on acute kidney injury (AKI) through paracrine/endocrine actions. If the protective effect is mediated in an endocrine manner, the injection of the factors that these cells secrete could be effective, but the effect of conditioned medium (CM) remains controversial.

Methods
In this study, we cultured mesenchymal stem cells (MSCs) and then transplanted them into an ischemia-reperfusion (I/R) injury model. CM was also injected into mice, and the histological changes, level of cell proliferation, loss of peritubular capillaries and anti-inflammatory and anti-apoptotic effects were examined at different time points.

Results
The results showed that MSC infusion improved renal function and histological alterations, leading to significantly reduced mortality. MSC administration also promoted kidney microvasculature repair, attenuated kidney peritubular capillary loss, increased the proliferation of parenchymal cells and decreased CD68-positive macrophage infiltration and apoptotic cells. Although we determined that CM contained proangiogenic factors, including hepatocyte growth factor (HGF), vascular endothelial growth factor-A (VEGF-A) and insulin-like growth factor-1 (IGF-1), no favorable effects were observed during the course of repair.

Conclusions
Our data show that MSC infusion promotes kidney repair in a variety of ways, including enhancement of the repair of peritubular capillaries and tubular epithelial cells and anti-inflammatory and anti-apoptotic effects. MSCs can secrete high levels of proangiogenic growth factors, but CM results in a nonsignificant improvement, indicating that MSCs play a role in kidney repair through paracrine rather than endocrine mechanisms. These results indicate that MSC infusion is a promising therapeutic strategy for promoting kidney repair after injury.
Application of seismic attributes and spectral decomposition for reservoir characterization of a complex fluvial system: Case study of the Carbonera Formation, Llanos foreland basin, Colombia
Authors: Torrado Lucia , Mann Paul , Bhattacharya Janok 
Published: August 2014

Hydrocarbon exploration in the Llanos foreland basin of eastern Colombia has traditionally focused on structural traps. However, in the past decade, the country’s oil demand has generated an increased interest in exploration for stratigraphic traps. We integrated [Formula: see text] of 3D seismic data volumes with eight wells in the Central Llanos area to assess the reservoir potential of the fluvial channel deposits of the Late Eocene–Oligocene Carbonera Formation in the Casanare Province. Distinguishing nonproductive, mud-filled channels from productive sand-filled channels is of economic importance for hydrocarbon exploration because both channel types can exhibit a similar seismic character. Our interpretation of the fluvial sandstone and the reservoir identification was based on 3D seismic attributes, including coherence, curvature, and spectral decomposition, and the analysis of fluvial geomorphology. Analysis of stratal slices through coherence, isofrequency amplitude cubes, and curvature cubes revealed (1) a northeast-trending meandering fluvial system with changes in the rivers’ paleoflow direction from southwest to northeast during the period of the Late Eocene to the Early Miocene, (2) development of prospective sandy point bars, scrolls, and sand bar deposits, and (3) channel ridges and bases accentuated by differential compaction dependent on the channel’s filling material. Based on our attribute analysis, we were able to characterize nonprospective mud-filled channels versus prospective sand-filled channels.
Fast gravity inversion of basement relief
Authors: Silva João B. C. , Santos Darcicléa F. , Gomes Karina P. 
Published: August 2014

Gravity interpretation of large sedimentary basins requires a large number of observations and of parameters estimations, so the development of very efficient gravity inversion methods applicable to such environments is of utmost importance. We found that the highly efficient Bott’s method can be cast in the framework of Gauss-Newton’s method for minimizing nonlinear functions. Also, we extended Bott’s method to (1) be applicable to sedimentary basins with density contrast between the sediments and the basement decreasing with depth according to different laws, (2) optimize the modulus of the parameter correction vector, (3) stabilize the solution by imposing that it be smooth, and (4) quit the iteration according to an objective and effective criterion. To keep up the efficiency of Bott’s method, stable solutions were obtained by applying a moving average to the usually unstable solution obtained at the last iteration. Solutions as efficacious as those obtained by the usual nonlinear method were produced by the present extension at a much smaller computation time. Nonlinear methods, with different implementations for solving a linear system of equations, required between one and two orders of magnitude more time to produce similar solutions using between 2000 and 3000 parameters and observations, for example.
LPXRFa, the Piscine Ortholog of GnIH, and LPXRF Receptor Positively Regulate Gonadotropin Secretion in Tilapia (Oreochromis niloticus)
Authors: Biran Jakob , Golan Matan , Mizrahi Naama , Ogawa Satoshi , Parhar Ishwar S. , Levavi-Sivan Berta 
Published: August 2014

Abstract
LPXRFamide (LPXRFa) peptides have been characterized for their ability to inhibit gonadotropin (GTH) release in birds and stimulate growth hormone (GH) release in frogs. However, their involvement in regulating the reproductive hypothalamo-pituitary-gonadal axis in mammals and fish is inconclusive. To study the role of LPXRFa peptides in the regulation of GTH secretion, we cloned tilapia LPXRFa and LPXRF receptor (LPXRF-R). Processing of the tilapia preproLPXRFa liberated three mature LPXRFa peptides that varied in size and post-translational modifications. Phylogenetic analysis of LPXRFa and the closely related RFamide peptide PQRFa showed clear clustering of each peptide sequence with its orthologs from various vertebrates. Signal-transduction analysis of the tilapia LPXRF-R in COS-7 cells showed clear stimulation of CRE-dependent luciferase activity, whereas the human NPFFR1 showed suppression of forskolin-induced CRE-dependent activity in this system. Administration of the tilapia pyroglutaminated LPXRFa-2 peptide to primary cell culture of tilapia pituitaries, or to reproductive female tilapia by ip injection, positively regulated both LH and FSH release in vivo and in vitro. Using double-labeled fluorescent in-situ hybridization and immunofluorescence, βLH cells were found to co-express both tilapia lpxrf and tilapia lpxrf-r mRNA, whereas some of the βFSH cells coexpressed only lpxrf-r mRNA. No coexpression of tilapia lpxrf-r was identified in GH-positive cells. These findings suggest that the LPXRFa system is a potent positive regulator of the reproductive neuroendocrine axis of tilapia.
Changes in RFamide-Related Peptide-1 (RFRP-1)-Immunoreactivity During Postnatal Development and the Estrous Cycle
Authors: Jørgensen Sara R. , Andersen Mille D. , Overgaard Agnete , Mikkelsen Jens D. 
Published: August 2014

Abstract
GnRH is a key player in the hypothalamic control of gonadotropin secretion from the anterior pituitary gland. It has been shown that the mammalian counterpart of the avian gonadotropin inhibitory hormone named RFamide-related peptide (RFRP) is expressed in hypothalamic neurons that innervate and inhibit GnRH neurons. The RFRP precursor is processed into 2 mature peptides, RFRP-1 and RFRP-3. These are characterized by a conserved C-terminal motif RF-NH2 but display highly different N termini. Even though the 2 peptides are equally potent in vitro, little is known about their relative distribution and their distinct roles in vivo. In this study, we raised an antiserum selective for RFRP-1 and defined the distribution of RFRP-1-immunoreactive (ir) neurons in the rat brain. Next, we analyzed the level of RFRP-1-ir during postnatal development in males and females and investigated changes in RFRP-1-ir during the estrous cycle. RFRP-1-ir neurons were distributed along the third ventricle from the caudal part of the medial anterior hypothalamus throughout the medial tuberal hypothalamus and were localized in, but mostly in between, the dorsomedial hypothalamic, ventromedial hypothalamic, and arcuate nuclei. The number of RFRP-1-ir neurons and the density of cellular immunoreactivity were unchanged from juvenile to adulthood in male rats during the postnatal development. However, both parameters were significantly increased in female rats from peripuberty to adulthood, demonstrating prominent gender difference in the developmental control of RFRP-1 expression. The percentage of c-Fos-positive RFRP-1-ir neurons was significantly higher in diestrus as compared with proestrus and estrus. In conclusion, we found that adult females, as compared with males, have significantly more RFRP-1-ir per cell, and these cells are regulated during the estrous cycle.