bluuebunny/crossref_metadata_2025_split huggingface dataset:
GEOMETRICAL AND GRAPHICS TRAINING IN COMPETENCE-BASED MODEL OF ENGINEERING HIGHER EDUCATION
Authors: ������  , Sosnin Nikolay 
Published: November 2013

The issues associated with the geometrical and graphics training contents
for the competence-based model of engineering higher education are discusses. Inconsistencies
in the process of curricula projecting arising as a result of transfer from
the traditional discipline-based to the innovative competence-based education model
are analyzed. It is concluded that the old education model does not fit with the new
educational goals to bring up students with a set of needed competences. Principles
and rules for designing the educational content structure suitable for a competencebased
model are outlined. It is proposed to develop the design and engineering competences
based on geometrical modeling on the basis of sequential-staged structure.
That methodology should be preferred, instructs the author, which allows to lift the
building-of-projecting-competences activities at the over-disciplinary and highly integrative
level.
Porous metal augments
Authors: Abolghasemian M. , Tangsataporn S. , Sternheim A. , Backstein D. J. , Safir O. A. , Gross A. E. 
Published: November 2013

The conventional method for reconstructing acetabular bone loss at revision surgery includes using structural bone allograft. The disadvantages of this technique promoted the advent of metallic but biocompatible porous implants to fill bone defects enhancing initial and long-term stability of the acetabular component. This paper presents the indications, surgical technique and the outcome of using porous metal acetabular augments for reconstructing acetabular defects. Cite this article: Bone Joint J 2013;95-B, Supple A:103–8.
Managing femoral bone loss in revision total hip replacement
Authors: Cross M. B. , Paprosky W. G. 
Published: November 2013

If a surgeon is faced with altered lesser trochanter anatomy when revising the femoral component in revision total hip replacement, a peri-prosthetic fracture, or Paprosky type IIIb or type IV femoral bone loss, a modular tapered stem offers the advantages of accurately controlling femoral version and length. The splines of the taper allow rotational control, and improve the fit in femoral canals with diaphyseal bone loss. In general, two centimetres of diaphyseal contact is all that is needed to gain stability with modular tapered stems. By allowing the proximal body trial to rotate on a well-fixed distal segment during trial reduction, appropriate anteversion can be obtained in order to improve intra-operative stability, and decrease the dislocation risk. However, modular stems should not be used for all femoral revisions, as implant fracture and corrosion at modular junctions can still occur. Cite this article: Bone Joint J 2013;95-B, Supple A:95–7.
Cemented femoral fixation
Authors: Murray D. W. 
Published: November 2013

There is a North Atlantic divide, with cementless femoral stems being used more frequently in the USA and cemented stems being used more frequently in many countries in Europe. This is primarily because different cemented stems have been used on different sides of the Atlantic and the results of the cemented stems in the US have often been poor, whereas the results of the stems used in Europe have been good. In the National registers in Europe, cemented stems have tended to achieve better results than cementless. Cite this article: Bone Joint J 2013;95-B, Supple A:51–2.
Patellofemoral replacement
Authors: Hofmann A. A. , Shaeffer J. F. , McCandless J. B. , Magee T. H. 
Published: November 2013

Isolated patellofemoral arthritis is a common condition and there are varying opinions on the most effective treatments. Non-operative and operative treatments have failed to demonstrate effective long-term treatment for those in an advanced stage of the condition. Newer designs and increased technology in patellofemoral replacement (PFR) have produced more consistent outcomes. This has led to a renewed enthusiasm for this procedure. Newer PFR prostheses have addressed the patellar maltracking issues plaguing some of the older designs. Short-term results with contemporary prostheses and new technology are described here.Cite this article: Bone Joint J 2013;95-B, Supple A:124–8.
Using Twitter to integrate practice and learning in journalism education: Could social media help to meet the twin challenge of both dimensions?
Authors: Hewett Jonathan 
Published: November 2013

Abstract
Developments in journalism and in education pose multiple challenges for journalism educators at a time of great change in both sectors. They face changing demands and expectations from a range of stakeholders, including students, practitioners and employers. The challenges result partly from new forms of journalism practice – such as the use of social media – and partly from changes in education, such as a recognition of the value of social constructivist approaches, including peer and informal learning. This article suggests that one way forward is to take advantage of the dual dimension of social media – as both a vocationally important part of the curriculum and as a medium with recognized educational potential. Drawing on a study of the use of one key social media platform (Twitter) by postgraduate journalism students, it highlights the scope for such an approach.
Numerical Investigation of Combined Top and Lateral Blowing in a Peirce-Smith Converter
Authors: Chibwe D. K. , Akdogan G. , Taskinen P. 
Published: November 2013

Abstract
Typical current operation of lateral-blown Peirce-Smith converters (PSCs) has the common phenomenon of splashing and slopping due to air injection. The splashing and wave motion in these converters cause metal losses and potential production lost time due to intermittent cleaning of the converter mouth and thus reduced process throughput. Understanding of the effect of combined top and lateral blowing could possibly lead to alternative technology advancement for increased process efficiency. In this study, computational fluid dynamics (CFD) simulations of conventional common practice (lateral blowing) and combined (top and lateral blowing) in a PSC were carried out, and results of flow variables (bath velocity, turbulence kinetic energy, etc.) were compared. The two-dimensional (2-D) and three-dimensional (3-D) simulations of the three-phase system (air–matte–slag) were executed utilizing a commercial CFD numerical software code, ANSYS FLUENT 14.0. These simulations were performed employing the volume of fluid and realizable turbulence models to account for multiphase and turbulent nature of the flow, respectively. Upon completion of the simulations, the results of the models were analysed and compared by means of density contour plots, velocity vector plots, turbulent kinetic energy vector plots, average turbulent kinetic energy, turbulent intensity contour plots and average matte bulk velocity. It was found that both blowing configuration and slag layer thickness have significant effects on mixing propagation, wave formation and splashing in the PSC as the results showed wave formation and splashing significantly being reduced by employing combined top- and lateral-blowing configurations.
Words for traditional Eurasian grain legumes in Uralic languages
Authors: Mikić Aleksandar , Stoddard Frederick L. 
Published: November 2013

Abstract
In the Fertile Crescent, grain legumes such as peas, lentils and faba beans were domesticated at about the same time as wheat and barley. In most branches of the Uralic language family, the words for pea have common roots, with the exception of the borrowings in the Finnic and Para-Finnic groups from Baltic and in Hungarian from Turkic. These results suggest that the pea may be an ancient crop among the Uralic peoples, with those who migrated losing the original Uralic word for it and borrowing it later from the non-Uralic peoples. Alternatively, the pea may have arrived after the Hungarian and Finnic peoples had migrated from the Uralic homeland. Moreover, words for lentil are clearly borrowed from neighbouring cultures, while words for faba bean are either derived from those for pea or borrowed from other cultures, demonstrating they were not among the first crops to be used by any of the Uralic peoples.
Separation of bi-harmonic differential operators on Riemannian
manifolds
Authors: Atia Hany A. , Alsaedi Ramzi S. , Ramady Ahmed 
Published: November 2013

Abstract.
Consider the bi-harmonic differential expression of the form

A
=
▵
▵
+
q

${A=\triangle \triangle +q}$

on a complete Riemannian manifold (M,g) with metric

g
,

${g,}$

where

▵

${\triangle }$

is the Laplacian on M and

q
≥
0

${q\ge 0}$

is a locally square
integrable function on M.
In the terminology of Everitt and Giertz, the differential expression A is
said to be separated in

L
2

(
M
)

${L^{2}( M) }$

if for all

u
∈

L
2

(
M
)

${u\in L^{2}( M) }$

such that

A
u
∈

L
2

(
M
)

${Au\in L^{2}( M) }$

, we have

q
u
∈

L
2

(
M
)

${
qu\in L^{2}( M)}$

. In this paper we give sufficient conditions
for A to be separated in

L
2

(
M
)

${L^{2}( M)}$

.
Ovarian function after allogeneic hematopoietic stem cell transplantation in childhood and adolescence
Authors: Vatanen A , Wilhelmsson M , Borgström B , Gustafsson B , Taskinen M , Saarinen-Pihkala U M , Winiarski J , Jahnukainen K 
Published: November 2013

ObjectiveThe aim of the study was to evaluate long-term ovarian function after allogeneic hematopoietic stem cell transplantation (HSCT) in childhood and adolescence.Subjects and methodsPredictive factors for ovarian function were evaluated among 92 adult or pubertal female survivors transplanted at Huddinge and Helsinki University Hospital during 1978–2000, at a mean age of 9±4.3 years (range 1–19). At the time of the study a mean±s.d. of 13±5.5 years (range 6–27) had elapsed since the HSCT and the mean age of the participants was 22±6.3 years (range 9–41).ResultsSpontaneous puberty based on breast development occurred in 40 and menarche in 30 of the 70 girls who were prepubertal at transplantation. Six out of 20 girls who received HSCT after initiation of pubertal development recovered their ovarian function. Younger age at HSCT, conditioning without total body irradiation (TBI), and a non-leukemia diagnosis predicted the spontaneous menarche. The incidence of menarche was higher after fractioned vs single fraction TBI (P<0.05), cyclophosphamide (Cy) vs busulfan (Bu)-based conditioning (P<0.05), and among leukemia patients transplanted at first remission vs later remissions (P<0.01) and with no cranial irradiation (cranial radiotherapy, CRT) vs given CRT (14–24 Gy) (P<0.01). The majority of recipients conditioned with only Cy vs TBI (P<0.001) or vs Bu-based regimens (P<0.01) showed preserved ovarian function and required no estrogen replacement at their latest follow-up visit at a mean age of 23±6.3 years (range 15–41). Ten women became pregnant.ConclusionsPatients conditioned with TBI or Bu-based regimes are at high risk of ovarian failure. Intensive anti-leukemia therapy before HSCT including CRT especially among relapsed patients may further decrease the possibility of spontaneous menarche.
Building Healthy Children: Evidence-Based Home Visitation Integrated With Pediatric Medical Homes
Authors: Paradis Heather A. , Sandler Mardy , Manly Jody Todd , Valentine Laurie 
Published: November 2013

BACKGROUND AND OBJECTIVES:
The Building Healthy Children (BHC) collaborative has successfully integrated home visitation into medical care of infants born to young, low-income mothers. Patients receive parenting education, and therapy for parent-child trauma and maternal depression through home visitation. The goals are to avoid child maltreatment, improve parent and child health, and enhance family functioning.

METHODS:
This randomized trial tests combining 3 evidence-based services versus screening and referral to community services only. Patients of 3 primary care practices are screened for eligibility (no previous Child Protective Services indication, maternal age &lt;21 at first delivery, and ≤2 children younger than age 3). Treatment families receive Parents as Teachers, child-parent psychotherapy, and interpersonal psychotherapy as needed. Outreach workers assist with concrete needs, including transportation to medical visits. Participant evaluations and reviews of pediatric medical charts are performed at regular intervals. Electronic medical record communications and BHC social workers ensure full integration with the medical home.

RESULTS:
Of all eligible families approached, 75% (n = 497) enrolled in BHC and 85% remained enrolled by age 3. At baseline, 37% of mothers were victims of child abuse/neglect, 22% showed significant depressive symptoms, and 59% of children were exposed to domestic violence. Preliminary analyses demonstrate avoidance of indicated Child Protective reports and foster placement and high rates of preventive care for enrolled children.

CONCLUSIONS:
BHC offers a unique model of evidence-based home visiting services integrated into primary care. This promising program demonstrates high retention rates and addresses the multidimensional needs of young at-risk families.
Near-Term Prediction of Sudden Cardiac Death in Older Hemodialysis Patients Using Electronic Health Records
Authors: Goldstein Benjamin A. , Chang Tara I. , Mitani Aya A. , Assimes Themistocles L. , Winkelmayer Wolfgang C. 
Published: November 2013

Summary

Background and objectives
Sudden cardiac death is the most common cause of death among individuals undergoing hemodialysis. The epidemiology of sudden cardiac death has been well studied, and efforts are shifting to risk assessment. This study aimed to test whether assessment of acute changes during hemodialysis that are captured in electronic health records improved risk assessment.

Design, setting, participants, & measurements
Data were collected from all hemodialysis sessions of patients 66 years and older receiving hemodialysis from a large national dialysis provider between 2004 and 2008. The primary outcome of interest was sudden cardiac death the day of or day after a dialysis session. This study used data from 2004 to 2006 as the training set and data from 2007 to 2008 as the validation set. The machine learning algorithm, Random Forests, was used to derive the prediction model.

Results
In 22 million sessions, 898 people between 2004 and 2006 and 826 people between 2007 and 2008 died on the day of or day after a dialysis session that was serving as a training or test data session, respectively. A reasonably strong predictor was derived using just predialysis information (concordance statistic=0.782), which showed modest but significant improvement after inclusion of postdialysis information (concordance statistic=0.799, P<0.001). However, risk prediction decreased the farther out that it was forecasted (up to 1 year), and postdialytic information became less important.

Conclusion
Subtle changes in the experience of hemodialysis aid in the assessment of sudden cardiac death and are captured by modern electronic health records. The collected data are better for the assessment of near-term risk as opposed to longer-term risk.
Development and Validation of a Prediction Rule Using the Oxford Classification in IgA Nephropathy
Authors: Tanaka Shigeru , Ninomiya Toshiharu , Katafuchi Ritsuko , Masutani Kosuke , Tsuchimoto Akihiro , Noguchi Hideko , Hirakata Hideki , Tsuruya Kazuhiko , Kitazono Takanari 
Published: November 2013

Summary

Background and objectives
The risk assessment for developing ESRD remains limited in patients with IgA nephropathy (IgAN). The aim of this study was to develop and validate a prediction rule for estimating the individual risk of ESRD in patients with IgAN.

Design, setting, participants, & measurements
A total of 698 patients with IgAN diagnosed by renal biopsy at Kyushu University Hospital (derivation cohort) between 1982 and 2010 were retrospectively followed. The Oxford classification was used to evaluate the pathologic lesions. The risk factors for developing ESRD were evaluated using a Cox proportional hazard model with a stepwise backward elimination method. The prediction rule was verified using data from 702 patients diagnosed at Japanese Red Cross Fukuoka Hospital (validation cohort) between 1979 and 2002.

Results
In the derivation cohort, 73 patients developed ESRD during the median 4.7-year follow-up. The final prediction model included proteinuria (hazard ratio [HR], 1.30; 95% confidence interval [95% CI], 1.16 to 1.45, every 1 g/24 hours), estimated GFR (HR, 0.84; 95% CI, 0.74 to 0.96, every 10 ml/min per 1.73 m2), mesangial proliferation (HR, 1.85; 95% CI, 1.10 to 3.11), segmental sclerosis (HR, 3.21; 95% CI, 1.37 to 7.51), and interstitial fibrosis/tubular atrophy (T1: HR, 5.30; 95% CI, 2.63 to 10.7; T2: HR, 20.5; 95% CI, 9.05 to 46.5) as independent risk factors for developing ESRD. To create a prediction rule, the score for each variable was weighted by the regression coefficients calculated using the relevant Cox model. The incidence of ESRD increased linearly with increases in the total risk scores (P for trend <0.001). Furthermore, the prediction rule demonstrated good discrimination (c-statistic=0.89) and calibration (Hosmer-Lemeshow test, P=0.78) in the validation cohort.

Conclusions
This study developed and validated a new prediction rule using clinical measures and the Oxford classification for developing ESRD in patients with IgAN.
Change in Albuminuria and eGFR Following Insulin Sensitization Therapy Versus Insulin Provision Therapy in the BARI 2D Study
Authors: August Phyllis , Hardison Regina M. , Hage Fadi G. , Marroquin Oscar C. , McGill Janet B. , Rosenberg Yves , Steffes Michael , Wall Barry M. , Molitch Mark 
Published: November 2013

Summary

Background and objectives
In the Bypass Angioplasty Revascularization Investigation 2 Diabetes randomized trial, glycemic control with insulin-sensitization therapy was compared with insulin-provision therapy in patients with type 2 diabetes and coronary artery disease. This study examined differences in albumin excretion and renal function in the insulin-sensitization group versus the insulin-provision group over 5 years.

Design, setting, participants & measurements
In total, 1799 patients with measurements of creatinine and urine albumin/creatinine ratio at baseline and at least two follow-up visits were included. Management of BP, lipids, and lifestyle counseling was uniform. Progression of albuminuria was defined as doubling of baseline albumin/creatinine ratio to at least 100 mg/g or worsening of albumin/creatinine ratio status on two or more visits. Worsening renal function was defined as >25% decline in estimated GFR and annualized decline of >3 ml/min per 1.73 m2 per year.

Results
By 6 months and thereafter, the mean glycated hemoglobin levels were lower in the insulin-sensitization group compared with the insulin-provision group (P<0.002 for each time point; absolute difference=0.4%). Albumin/creatinine ratio increased over time in the insulin-sensitization group (P value for trend<0.001) and was stable in the insulin-provision group. Risk for progression of albumin/creatinine ratio was higher in the insulin-sensitization group compared with the insulin-provision group (odds ratio, 1.59; 95% confidence interval, 1.25 to 2.02; P=0.02). Over 5 years, albumin/creatinine ratio increased from 11.5 (interquartile range=5.0–46.7) to 15.7 mg/g (interquartile range=6.2–55.4) in the insulin-sensitization group (P<0.001) and from 12.1 (interquartile range=5.3–41.3) to 12.4 mg/g (interquartile range=5.8–50.6) in the insulin-provision group (P=0.21). Estimated GFR declined from 75.0±20.6 to 66.3±22.6 ml/min per 1.73 m2 in the insulin-sensitization group (P<0.001) and from 76.1±29.5 to 66.8±22.1 ml/min per 1.73 m2 in the insulin-provision group (P<0.001).

Conclusion
Over 5 years, despite lower glycated hemoglobin levels, the insulin-sensitization treatment group had greater progression of albumin/creatinine ratio compared with the insulin-provision treatment group. Decline in estimated GFR was similar.
Molecular Genetic Markers as a Basis for Personalized Medicine / MOLEKULARNO-GENETIČKI MARKERI KAO OSNOV ZA PERSONALIZOVANU MEDICINU
Authors: Pavlović Sonja , Zukić Branka , Stojiljković Petrović Maja 
Published: November 2013

Summary
Nowadays, genetics and genomics are fully integrated into medical practice. Personalized medicine, also called genome-based medicine, uses the knowledge of the genetic basis of disease to individualize treatment for each patient. A number of genetic variants, molecular genetic markers, are already in use in medical practice for the diagnosis, prognosis and follow-up of diseases (monogenic hereditary disorders, fusion genes and rearrangements in pediatric and adult leukemia) and presymptomatic risk assessment (BRCA 1/2 for breast cancer). Additionally, the application of pharmacogenomics in clinical practice has significantly contributed to the individualization of therapy in accordance with the patient’s genotype and gene expression profile. Genetic testing for several pharmacogenomic markers (TPMT, UGT1A1, CYP2C9, VKORC1) is mandatory or recommended prior to the initiation of therapy. The most important achievement of genome-based medicine is molecular-targeted therapy, tailored to the genetic profile of a disease. Testing for gene variants in cancer (BCR-ABL, PML/RARa, RAS, BCL-2) is part of the recommended evaluation for different cancers, in order to achieve better management of the disease. The ultimate goal of medical science is to develop gene therapy which will fight or prevent a disease by targeting the disease causing genetic defect. Gene therapy technology is rapidly developing, and has already been used with success. Although medicine has always been essentially »personal« to each patient, personalized medicine today uses modern technology and knowledge in the field of molecular genetics and genomics, enabling a level of personalization which leads to significant improvement in health care.