bluuebunny/crossref_metadata_2025_split huggingface dataset:
Benefits and barriers to the public health pharmacy: a qualitative exploration of providers’ and commissioners’ perceptions of the Healthy Living Pharmacy framework
Authors: Firth Hannah , Todd Adam , Bambra Clare 
Published: April 2015

Aims: The aims of this study were to explore the barriers to the implementation and progression of the Healthy Living Pharmacy (HLP) framework, from both provider and commissioner perspectives, and to ascertain whether the successes and barriers of the framework perceived by pharmacies are shared with commissioners. Methods: A structured qualitative interview study, using purposive sampling, was undertaken with 11 community pharmacists and 11 Healthy Living Champions (providers) from HLPs in the north of England. Four commissioners of such services were also interviewed. Interviews were analysed using a thematic approach. Results: There were many aspects of the HLP framework that the service ‘providers’ were positive about, namely, workforce development, engagement (particularly with the smoking cessation service) and as a motivation for pharmacy teams. However, there were areas of concern about low awareness among pharmacy users, the time involved in delivery, as well as financial considerations. These were exemplified by the health checks element. Commissioners also expressed concerns about health checks as well as a lack of cohesion between commissioners and service providers and a poor understanding of the broader framework. Conclusion: The HLP framework was perceived as valuable by providers although there were areas of concern. A key barrier to the framework – perceived by both providers and commissioners – was the implementation of health checks. This should be considered in future commissioning.
Does More Public Health Spending Buy Better Health?
Authors: Marton James , Sung Jaesang , Honore Peggy 
Published: April 2015

Background: In this article, we attempt to address a persistent question in the health policy literature: Does more public health spending buy better health? This is a difficult question to answer due to unobserved differences in public health across regions as well as the potential for an endogenous relationship between public health spending and public health outcomes. Methods: We take advantage of the unique way in which public health is funded in Georgia to avoid this endogeneity problem, using a twelve year panel dataset of Georgia county public health expenditures and outcomes in order to address the “unobservables” problem. Results: We find that increases in public health spending lead to increases in mortality by several different causes, including early deaths and heart disease deaths. We also find that increases in such spending leads to increases in morbidity from heart disease. Conclusions: Our results suggest that more public health funding may not always lead to improvements in health outcomes at the county level.
Fbxl10 overexpression in murine hematopoietic stem cells induces leukemia involving metabolic activation and upregulation of Nsg2
Authors: Ueda Takeshi , Nagamachi Akiko , Takubo Keiyo , Yamasaki Norimasa , Matsui Hirotaka , Kanai Akinori , Nakata Yuichiro , Ikeda Kenichiro , Konuma Takaaki , Oda Hideaki , Wolff Linda , Honda Zen-ichiro , Wu Xudong , Helin Kristian , Iwama Atsushi , Suda Toshio , Inaba Toshiya , Honda Hiroaki 
Published: April 2015

Key Points
Fbxl10 is a bona fide oncogene in vivo. Fbxl10 overexpression in HSCs induces mitochondrial metabolic activation and enhanced expression of Nsg2.
Creation of a free, Internet-accessible database: the Multiple Target Ligand Database
Authors: Chen Chao , He Yang , Wu Jianhui , Zhou Jinming 
Published: April 2015

Abstract

Background
Polypharmacology plays an important part in drug discovery, and remains a major challenge in drug development. Identification of the underlying polypharmacology of a drug, as well as development of polypharmacological drugs, have become important issues in the pharmaceutical industry and academia.

Description
Herein, through data mining of the Protein Data Bank (PDB), a free, Internet-accessible database called the Multiple Target Ligand Database (MTLD; www.mtdcadd.com) was constructed. The MTLD contains 1,732 multiple-target ligands (MTLs) which bind to 14,996 binding sites extracted from 12,759 PDB structures. Among MTLs, 222 entries are approved drugs and 1,334 entries are drug-like compounds. The MTLD could be an extremely useful tool in the development of polypharmacological drugs. It also sheds light on the side effects of drugs through anticipation of their multiple functions and similarities in the binding sites of multiple targets. The entire database is free for online searching, browsing, and downloading.

Conclusion
As a crucial expansion of the PDB, increasing numbers of MTLs will be included in the MTLD. Eventually, it will become an efficient platform to obtain useful information on MTLs and their underlying polypharmacology.
Association of dietary pattern with biochemical blood profiles and bodyweight among adults with Type 2 diabetes mellitus in Tehran, Iran
Authors: Darani Zad Nasrin , Mohd Yusof Rokiah , Esmaili Haleh , Jamaluddin Rosita , Mohseni Fariba 
Published: April 2015

Abstract
Background
This study was conducted to identify dietary patterns and evaluated their association with biochemical blood profiles and body weight among adults with type 2 diabetes mellitus.

Methods
This was a cross sectional study conducted among 400 patients with type 2 diabetes mellitus in Tehran from March to August 2013. Biochemical blood profiles, socio-demographic, lifestyle, anthropometric measurements, and dietary data were obtained. Dietary data from food frequency questionnaire were used to derive dietary patterns. Factor analysis was conducted to ascertain the dietary patterns, and analysis of covariance was fitted to assess the relation between blood profiles, body weight and adherence to dietary patterns.

Results
Three dietary patterns by factor analysis were identified, Vegetable & Poultry, Western and Semi-healthy. After control for potential confounders, body mass index (b = −0/03, p < 0.05) were negatively associated with vegetable and poultry dietary pattern. Conversely, total cholesterol (b = 0.004, p < 0.01) and fasting blood glucose (b = 0.014, p < 0.05) were positively associated with western dietary pattern. A dietary pattern labeled as semi-healthy pattern was found to be positively related to HDL-cholesterol (b = 0.006 p < 0.01). Associations between semi-healthy pattern, LDL-cholesterol (b = −0.120 p < 0.05) and waist circumference (b = −0.020, p < 0.05) were negative.

Conclusion
Adherence to Vegetable & Poultry dietary pattern was favorably related to body weight, semi healthy related to lower LDL and higher HDL cholesterol whereas western related to higher fasting blood glucose and total cholesterol. Further studies are necessary to confirm the benefits of the dietary patterns for diabetes.
Large animal models in experimental knee sports surgery: focus on clinical translation
Authors: Madry Henning , Ochi Mitsuo , Cucchiarini Magali , Pape Dietrich , Seil Romain 
Published: April 2015

Abstract
Large animal models play a crucial role in sports surgery of the knee, as they are critical for the exploration of new experimental strategies and the clinical translation of novel techniques. The purpose of this contribution is to provide critical aspects of relevant animal models in this field, with a focus on paediatric anterior cruciate ligament (ACL) reconstruction, high tibial osteotomy, and articular cartilage repair. Although there is no single large animal model strictly replicating the human knee joint, the sheep stifle joint shares strong similarities. Studies in large animal models of paediatric ACL reconstruction identified specific risk factors associated with the different surgical techniques. The sheep model of high tibial osteotomy is a powerful new tool to advance the understanding of the effect of axial alignment on the lower extremity on specific issues of the knee joint. Large animal models of both focal chondral and osteochondral defects and of osteoarthritis have brought new findings about the mechanisms of cartilage repair and treatment options. The clinical application of a magnetic device for targeted cell delivery serves as a suitable example of how data from such animal models are directly translated into in clinical cartilage repair. As novel insights from studies in these translational models will advance the basic science, close cooperation in this important field of clinical translation will improve current reconstructive surgical options and open novel avenues for regenerative therapies of musculoskeletal disorders.
Autologous Stem-Cell Transplantation Without Hematopoietic Support for the Treatment of Hematologic Malignancies in Jehovah's Witnesses
Authors: Ford Patricia A. , Grant Shakira J. , Mick Rosemarie , Keck Gina 
Published: April 2015

Purpose Autologous stem-cell transplantation (ASCT) has shown to provide curative benefit in patients with relapsed lymphoma and multiple myeloma (MM), often requiring hematopoietic support until marrow engraftment. Because of Jehovah's Witnesses' (JW) refusal of blood products, treatment challenges arise. This study represents 125 JWs with lymphoma (n = 55), MM (n = 68), or amyloidosis (n = 2), treated with high-dose chemotherapy (HDC) and ASCT without transfusions. Patients and Methods Priming with intravenous iron and erythropoietin occurred to increase hemoglobin (Hb) pretransplantation. Cytokine mobilization of stem-cells was used. Delay to HDC was done to allow Hb and platelets to approach 11 g/dL and 100 × 103/μL, respectively. Patients with MM received a standard dose of melphalan 200 mg/m2, with dose reduction for severe kidney dysfunction. Patients with lymphoma received carmustine 300 mg/m2, cyclophosphamide 1,500 mg/m2 on days 2 through 5 (total 6 g/m2), and etoposide 700 mg/m2 per day on days 2 through 4 (total 2,100 mg/m2). Post-transplantation, a combination of granulocyte colony-stimulating factor, erythropoietin, aminocaproic acid, and phytonadione was administered. Results There were two major and 15 minor bleeding complications, none occurring at platelets less than 5.0 × 103/μL, with six (4.8%) treatment-related mortalities. The median decrease in Hb was 5.0 g/dL, with median Hb nadir of 7.0 g/dL. The median number of days with platelet count less than 10 × 103/μL was 3, with median platelet nadir of 5.0 × 103/μL. Cardiac complications occurred in 40 patients (32%). Conclusion ASCT can safely be performed without transfusion support. A platelet transfusion trigger of ≤ 5 × 103/μL may be appropriate in select patients. Pharmacotherapy and cardiac monitoring are effective in the management of cardiac complications.
Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel
Authors: Wilson Parker C. , Fitzgibbon Wayne R. , Garrett Sara M. , Jaffa Ayad A. , Luttrell Louis M. , Brands Michael W. , El-Shewy Hesham M. 
Published: April 2015

AbstractAngiotensin II (AngII) plays a critical role in the regulation of vascular tone and blood pressure mainly via regulation of Ca2+ mobilization. Several reports have implicated sphingosine kinase 1 (SK1)/sphingosine 1-phosphate (S1P) in the mobilization of intracellular Ca2+ through a yet-undefined mechanism. Here we demonstrate that AngII-induces biphasic calcium entry in vascular smooth muscle cells, consisting of an immediate peak due to inositol tris-phosphate-dependent release of intracellular calcium, followed by a sustained transmembrane Ca2+ influx through store-operated calcium channels (SOCs). Inhibition of SK1 attenuates the second phase of transmembrane Ca2+ influx, suggesting a role for SK1 in AngII-dependent activation of SOC. Intracellular S1P triggers SOC-dependent Ca2+ influx independent of S1P receptors, whereas external application of S1P stimulated S1P receptor-dependent Ca2+ influx that is insensitive to inhibitors of SOCs, suggesting that the SK1/S1P axis regulates store-operated calcium entry via intracellular rather than extracellular actions. Genetic deletion of SK1 significantly inhibits both the acute hypertensive response to AngII in anaesthetized SK1 knockout mice and the sustained hypertensive response to continuous infusion of AngII in conscious animals. Collectively these data implicate SK1 as the missing link that connects the angiotensin AT1A receptor to transmembrane Ca2+ influx and identify SOCs as a potential intracellular target for SK1.
Optical and Cognitive Illusions: The MIT Visualizing Cultures Controversy in Spring 2006
Authors: Elman Benjamin A. 
Published: April 2015

The “rise of China” narrative in the twenty-first century is replacing the long-standing “rise of Japan” story line of the twentieth century. This article examines the role of wars in redirecting public opinion and, in particular, the effect of the 1894–95 war in refracting Qing Dynasty (1644–1911) reforms since the 1860s into “failures” and contemporary Meiji (1868–1912) reforms into “successes.” To grasp this dramatic reversal, we need new interpretations of the 1894–95 Sino-Japanese War that will unravel the Japanese and global propaganda that engulfed the world press in this “Social Darwinian” era of scrambling empires out of which the “rise of Japan” and the “fall of China” narratives emerged.
Challenging this standard narrative, the article uses Meiji woodblock prints of the war to demonstrate how “optical illusions” were constructed to support a Japanese master-narrative of Qing “backwardness,” which influenced not only Europeans and US citizens but also modern Chinese reformers and revolutionaries in their efforts to fashion a “new” China that would one day catch up with and surpass Japan. This 1895 reversal of narratives lies in the background of the 2006 MIT controversy, namely, the current “great reversal” occurring between Japan and China. The MIT controversy thus serves as an indicator of a sea change in the global perceptions of China and Japan in the present day. The current reversal that sparked the MIT controversy must be understood in light of a new historical context that has challenged a perennial Japan-centered perspective since 1895, namely, that the Japanese are the dominant power, culture, and people in East Asia.
The rise of a China-centered narrative since the late 1990s has superseded the assumed preeminence of Japan in Asia, a preeminence that began in the aftermath of what the Japanese misrepresented as the so-called “First” Sino-Japanese War. Japanese accounts since 1895 have conveniently repressed Toyotomi Hideyoshi's 1592 invasion of Korea, for example, which touched off the actual first Sino-Japanese War and led to the unilateral withdrawal of Japan's troops from the Korean peninsula. Hideyoshi's defeat was displaced as a false start in Sino-Japanese relations after 1895.
Resonance Raman Spectroscopy with Chemical State Selectivity on Histidine and Acetamide Using Synchrotron Radiation
Authors: Saito Makina , D’Amico Francesco , Camisasca Gaia , Bencivenga Filippo , Cucini Riccardo , Gessini Alessandro , Principi Emiliano , Ogura Takashi , Masciovecchio Claudio 
Published: April 2015

Abstract
We report on ultraviolet resonance Raman scattering experiments carried out on two model substances: histidine and acetamide using a UV synchrotron radiation source. In the case of aqueous histidine solution each protonated state of histidine tautomers was selectively excited by tuning the incident wavelength and the vibrational state of each protonated state was studied. We also demonstrated that the local pH condition of histidine can be identified directly from the spectra above pH 9. In the case of acetamide, the resonance Raman bands of acetamide with a stronger hydrogen bond at the NH2 site and weaker hydrogen bond at the C=O site were selectively observed. These findings will extend the selectivity and sensitivity of RR spectroscopy that is helpful to understanding protein functionality.
Use of Modified Self-Frictional Laguerre Power Series for Study of Atomic Nuclear Attraction Integrals of Noninteger Slater-Type Orbitals and Coulomb–Yukawa-Like Potentials
Authors: Guseinov I I 
Published: April 2015

Abstract
Using complete orthonormal L(α*)-modified self-frictional Laguerre polynomials (L(α*)-MSFLPs) in standard convention introduced by the author, the expressions for transformation of χ-noninteger Slater type orbitals (χ-NISTOs) and V-noninteger Coulomb–Yukawa-like potentials (V-NICYPs) to the MSF Laguerre power series are suggested, where α* are the integer (α* = α, −∞ &lt; α ≤ 2) or noninteger (α* ≠ α, −∞ &lt; α* &lt; 3) SF quantum numbers. By the use of these power series, the atomic nuclear attraction integrals of χ-NISTOs and V-NICYPs are evaluated. The convergence and accuracy of obtained MSF Laguerre power series are tested by calculating concrete cases.
The influence of light and water mass on bacterial population dynamics in the Amundsen Sea Polynya
Authors: Richert Inga , Dinasquet Julie , Logares Ramiro , Riemann Lasse , Yager Patricia L. , Wendeberg Annelie , Bertilsson Stefan 
Published: April 2015

Abstract
Despite being perpetually cold, seasonally ice-covered and dark, the coastal Southern Ocean is highly productive and harbors a diverse microbiota. During the austral summer, ice-free coastal patches (or polynyas) form, exposing pelagic organisms to sunlight, triggering intense phytoplankton blooms. This strong seasonality is likely to influence bacterioplankton community composition (BCC). For the most part, we do not fully understand the environmental drivers controlling high-latitude BCC and the biogeochemical cycles they mediate. In this study, the Amundsen Sea Polynya was used as a model system to investigate important environmental factors that shape the coastal Southern Ocean microbiota. Population dynamics in terms of occurrence and activity of abundant taxa was studied in both environmental samples and microcosm experiments by using 454 pyrosequencing of 16S rRNA genes. We found that the BCC in the photic epipelagic zone had low richness, with dominant bacterial populations being related to taxa known to benefit from high organic carbon and nutrient loads (copiotrophs). In contrast, the BCC in deeper mesopelagic water masses had higher richness, featuring taxa known to benefit from low organic carbon and nutrient loads (oligotrophs). Incubation experiments indicated that direct impacts of light and competition for organic nutrients are two important factors shaping BCC in the Amundsen Sea Polynya.
Producing a meaningful difference: The significance of small creative acts in composing within online participatory remix practices
Authors: Michielse Maarten , Partti Heidi 
Published: April 2015

Abstract
Online remix competitions focus strongly on community interaction, creative production and sharing, and can be seen as manifestations of an emergent musical participatory culture within which participants collectively generate and rework cultural content. This article engages in a theoretical exploration of the ways in which participants of online remix contests collectively discuss and exchange different takes on a single song, and how they appraise small similarities and differences in these derivative works. The concept of the small creative act offers a heuristic lens through which to investigate online participatory remix practices. Examples from a recent ethnographic study of the international IndabaMusic.com online remix platform illustrate how online remix contests enable the development of aural discernment through novel forms of access to the field of musical works, encourage growth into expertise through a collective and participatory form of appropriation and provide the means for making meaningful differences through the constant repositioning of oneself relative to others in the remix community. Finally, the article discusses the implications that practices based on the idea of the small creative act have for learning to compose in online remix communities.
Participatory and digital cultures in practice: Perspectives and possibilities in a graduate music course
Authors: Tobias Evan S. 
Published: April 2015

Abstract
Music educators seeking to address contemporary society might look to existing and emerging ways that people engage with music. Participatory culture(s) as discussed primarily in media studies and related fields offers a fruitful context for expanding music education. This study addresses graduate music students’ perspectives on integrating expressions and circulations related to participatory culture in music education settings. Participants described musical expressions such as appropriating or transforming existing music as having creative and learning potential. Participants also expressed how students’ creative expressions in the form of appropriating music could be meaningful and empowering. Participants experienced challenges ranging from difficulty envisioning concrete applications of participatory culture in existing curricular structures such as large ensembles, to unresolved perspectives of related ethical, legal, philosophical and pedagogical issues. Findings suggest that media and musical skills specific to participatory culture along with related understanding and dispositions are important for its realization in music education.
Participation in the School Orchestra and String Teachers Facebook v2 group: An online community of practice
Authors: Palmquist Jane E. , Barnes Gail V. 
Published: April 2015

Abstract
The School Orchestra and String Teachers v2 (SOST v2) Facebook group is a self-directed online community of practice. In this study we describe the posting behaviour of SOST v2 members during the initial eighteen months of its launch on Facebook. Analysis of member-initiated posts (N=1,676) revealed the following:
•	Nearly 22 per cent of SOST v2 members contributed posts.
•	Repertoire (n=276), teaching advice (n=252) and links to articles and websites (n=231) were the most frequently posted topics.
•	SOST v2 members represent Canada, Hong Kong, Morocco, Turkey, the United Kingdom and the United States.
School orchestra and string teachers have formed a viable community of practice on Facebook. Facebook groups provide a means by which music teachers may form a network for informal learning for music teachers and communicate easily with peers across the world. The challenges and potential of social media research are discussed.
Rediscovery and range extension of the black-shouldered opossum Caluromysiops irrupta Sanborn, 1951 (Didelphimorphia, Didelphidae) in Brazil
Authors: Barbosa Júlia Laterza , Custódio Rogério José , Brandão Marcus Vinicius 
Published: April 2015

Abstractis a rare marsupial that inhabits the western part of the Amazon forest. It is an arboreal and nocturnal species, and its real distribution is yet to be investigated. Since its description by Sanborn in 1951, only eight records were reported from Peru, Colombia, and northwestern Brazil. In this work, we provide a new record for Mato Grosso state, Brazil, based on a specimen captured during a faunal rescue of vegetation suppression. This record represents the easternmost limit of the distribution of the black-shouldered opossum and the second known specimen from Brazil, extending its range about 718 km toward an area close to lands under intensive use and high rate of deforestation. The present record is an evidence of the potential of faunal rescues for generating data, which are useful for conservation and management purposes in the Neotropics.