bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer immunotherapy and its facilitation by nanomedicine
Authors: Sui Chao , Wu Heqing , Li Xinxin , Wang Yuhang , Wei Jiaqi , Yu Jianhua , Wu Xiaojin 
Published: August 2024

AbstractCancer immunotherapy has sparked a wave of cancer research, driven by recent successful proof-of-concept clinical trials. However, barriers are emerging during its rapid development, including broad adverse effects, a lack of reliable biomarkers, tumor relapses, and drug resistance. Integration of nanomedicine may ameliorate current cancer immunotherapy. Ultra-large surface-to-volume ratio, extremely small size, and easy modification surface of nanoparticles enable them to selectively detect cells and kill cancer cells in vivo. Exciting synergistic applications of the two approaches have emerged in treating various cancers at the intersection of cancer immunotherapy and cancer nanomedicine, indicating the potential that the combination of these two therapeutic modalities can lead to new paradigms in the treatment of cancer. This review discusses the status of current immunotherapy and explores the possible opportunities that the nanomedicine platform can make cancer immunotherapy more powerful and precise by synergizing the two approaches.
Boundary determination for hybrid imaging from a single measurement
Authors: Brander Tommi , Ringholm Torbjørn 
Published: August 2024

Abstract
We recover the conductivity σ at the boundary of a domain from a combination of Dirichlet and Neumann boundary data and generalized power/current density data at the boundary, from a single quite arbitrary set of data, in AET or CDII.
The argument is elementary, algebraic and local.
More generally, we consider the variable exponent

p
⁢

(
⋅
)

{p(\,\cdot\,)}

-Laplacian as a forward model with the interior density data

σ
⁢

|

∇
⁡
u

|

q

{\sigma|\nabla u|^{q}}

, and find out that single measurement specifies the boundary conductivity when

p
-
q

≥
1

{p-q\geq 1}

, and otherwise the measurement specifies two alternatives.
We present heuristics for selecting between these alternatives.
Both p and q may depend on the spatial variable x, but they are assumed to be a priori known.
We illustrate the practical situations with numerical examples with the code available.
The inverse problem of heat conduction in the case of non-uniqueness: A functional identification approach
Authors: Borukhov Valentin Terentievich , Zayats Galina M. 
Published: August 2024

Abstract
A problem of identification of the set of a thermal-conductivity coefficients for the nonlinear heat equation in the case of non-uniqueness is considered. Classes of inverse heat conduction problems (IHCP) with a non-unique solution are defined. Explicit descriptions of sets of thermal-conductivity coefficients for these classes are obtained. For solving the identification problem the functional identification approach is used. Unlike traditional methods, the proposed algorithm does not utilize approximations of the coefficient with a finite system of basis functions. The results of computational experiments are presented. It is shown that the functional identification approach makes it possible to numerically identify the non-uniqueness of the solution of the inverse problem of heat conduction.
A modified iteratively regularized Landweber iteration method: Hölder stability and convergence rates
Authors: Mittal Gaurav , Giri Ankik Kumar 
Published: August 2024

Abstract
In this paper, we formulate the modified iteratively regularized Landweber iteration method in Banach spaces to solve the inverse problems for which the forward operator may be smooth or non-smooth. We study the convergence analysis of the modified method for both the perturbed as well as unperturbed data by utilizing the Hölder stability estimates. In the presence of perturbed data, we terminate the method via a discrepancy principle and show that it is in fact a convergence regularization method that terminates within a few iterations. In the presence of unperturbed data, we show that the iterates converge to the exact solution. Additionally, we deduce the convergence rates in the presence of perturbed as well as unperturbed data. Finally, we discuss two inverse problems on which the method is applicable.
Nonlinear system identification via sparse Bayesian regression based on collaborative neurodynamic optimization
Authors: Okunev Alexey , Burnaev Evgeny 
Published: August 2024

Abstract
Sparse identification of nonlinear dynamics is a popular approach to system identification. In this approach system identification is reformulated as a sparse regression problem, and the use of a good sparse regression method is crucial. Sparse Bayesian learning based on collaborative neurodynamic optimization is a recent method that consistently produces high-quality solutions. In this article, we extensively assess how this method performs for ordinary differential equation identification. We find that it works very well compared with sparse regression algorithms currently used for this task in terms of the tradeoff between the approximation accuracy and the complexity of the identified system. We also propose a way to substantially reduce the computational complexity of this algorithm compared with its original implementation, thus making it even more practical.
Experimental analysis of failure modes depending on different loading conditions applied on cylindrical polyamide 66 gears
Authors: Hriberšek Matija , Kulovec Simon 
Published: August 2024

Abstract
Engineering plastics are increasingly used for gearing systems, such as in the automotive sector, e-mobility sector, and household appliances. The basic task of the gearing system is to efficiently transfer power from the source to the application user. The use of engineering plastics for gearing applications is conditioned by the lack of tribological characteristics of material pairs which influence on fatigue and wear behaviour of the whole gearing system. The paper presents testing of the steel/Polyamide 66-gear by determining fatigue life in an infinite area, considering high precision optical measurements in the range of micro-meter accuracy of abrasion flank wear together with surface temperature in contact, providing an important database for engineers about material suitability for appropriate mechanical systems. Observing the results, gear flank wear of PA66 HT is directly proportional to the meshing temperature and torque. Thermal melting is a characteristic failure mode of the polymer gears which are exposed to higher load levels. In the middle torques, the dominant failure mode is flank fracture known as pitch point fracture. The greater impact of the gear wear mechanism occurs at lower torques where initial crack propagation starts at the pitch point and ends in the tooth root area.
Reshaping the library landscape: Exploring the integration of artificial intelligence in libraries
Authors: Kumar Pankaj , Jyoti  
Published: August 2024

It's evident that the integration of Artificial Intelligence (AI) in libraries is reshaping traditional library services, offering new possibilities to enhance user experiences and streamline operations. Artificial Intelligence integration is emerging as a revolutionary trend in libraries, changing traditional library services and functions as they adapt to the evolving digital world. In order to better understand how AI technologies could enhance user experiences, expedite operations, and transform information management, this study examines the implications, problems, and opportunities related to their integration in libraries. Using artificially intelligent algorithms, natural language processing, and other forms of innovative technologies to automate procedures, enhance decision-making, and offer customized assistance is the process of integrating artificial intelligence (AI) into libraries. Also, this paper includes some key points, as virtual assistants can help users navigate through the vast resources available in libraries, making it easier for them to find relevant information. AI applications, such as intelligent cataloging systems, can automate the organization and categorization of resources, saving time for library staff. Decision-making processes within the library, such as resource allocation and collection development, can be enhanced through AI-driven insights. The integration of AI in libraries brings both opportunities and challenges. Opportunities include improved efficiency, enhanced user services, and better decision-making. Additionally, addressing implications and challenges helps in fostering a balanced approach to AI integration Challenges may include issues related to privacy, ethical considerations, and the need for staff training to adapt to new technologies. The examination of case studies and illustrations adds practical insights to the theoretical understanding of how AI can be effectively utilized in library settings.
Promoting reading habits among the users by the libraries: An overview
Authors: Lokeshappa H  
Published: August 2024

: Information is generated in various ways, recorded in a variety of forms, and made available for users. Information sources are in various forms, viz. books, journals, periodicals, newsletters, databases, reports, directories, dictionaries, encyclopedias, yearbooks, theses, dissertations, monographs, patents, etc., The information centers deserve to provide the required information to the users without any charges and without any discrimination, whether it is printed or in any digital format.: To know the concept of reading, analyze the type of information sources available in the libraries, know the status of reading habits, identify the causes for poor reading habits, find the role importance or the role of librarians in the promotion of reading habits, and also find the remedies for good reading atmosphere among the users. : Review of literature or the literature search method used for the paper.: Promote the marketing of library services, have positive contact with users, new/rare books exhibitions, services through social media, best user award, etc.: The different issues towards promoting reading culture among the users and found that there is essential need to develop reading culture in the society. In order to continue the reading habits and make the society well literate in every area of subjects and use reading for everyone’s life.
Unraveling the digital landscape: A study of web impact factor and link analysis of state law universities of India
Authors: Manhas Rajeev , Kaur Shinderpal 
Published: August 2024

In the era of digital landscapes, a variety of web analytics tools can be used to assess the online presence and influence of higher education institutions, particularly universities. Using these tools to rank universities based on the extent of their online visibility. Using web analytics techniques like Google Page Rank (GPR) and Alexa Traffic Rank (ATR), the researchers in this study examined the State Law Universities of India and reported the rankings. The investigators also looked into how the rich files were used accordingly reported the ranking of the Indian State Law Universities. The researchers looked at the web impact factor of 24 State Law Universities in India that were approved by the University Grants Commission in New Delhi. The researchers used GPR, ATR, and Google Search Engine for link analysis and further to demonstrate the impact factor (web) based on the available literature on the topic. National Law University, Delhi is ranked #1 in the world in the Alexa Traffic Ranking according to the study's findings. The National Law School of India University, located in Karnataka, is ranked first for rich files and first in GPR.
Bibliometric analysis of the structure and evolution of research on epigenetics
Authors: Santhakumar R. , Mahalakshmi S. , Kalaiappan V. 
Published: August 2024

Epigenetics, one of the most rapidly intensifying fields of biological research and this field has experienced remarkable research attention in recent years, yet few studies investigated a bibliometric analysis of epigenetics research. In this research, the article analysed the provides a comprehensive overview of literature on epigenetics published between 2012 and 2021. The Web of Science Core Collection Database was used to retrieve all related publications. The search was conducted on September 20th, 2023 and select articles or reviews as the document type which resulted in 9,677 publications. The scientometric tools were applied to collect information on publications years of these papers, most prolific authors, famous journals, most productive countries and organizations, language and subjects. A total of 9,677 publications were retrieved. The publication's output showed a gradual upward trend from 2012 to 2021. The highest number of publications was 1,183 published in 2021. In our study, 117 countries contributed to this area of research in total. The top three countries were the USA, China, and Germany. Proceedings of the National Academy of Sciences of the United States of America was the journal with the highest production. Zhang Y is the most productive author with 65 (0.67%) publications. The 9,677 epigenetics articles were published by 8,145 different authoring organizations. University of Michigan is the institution where the most research related to epigenetics analysis has been developed, with 141 publications. Epigenetics is an emerging area of scientific research. However, most scientific research is conducted in environmental influences and relatively few are on human models. Analysis of the academic communities performing epigenetics research may provide scientific evidence. The method proposed in this research can provide reference for future bibliometric studies. Advancement and development in a particular area of research are illustrated by the ever-growing body of scientific literature. This accumulation of literature describes various developments and innovations that occur over time and contains potentially valuable information that can be evaluated and classified to explain current emerging trends. In this study, we present a scientometric analysis of the retrieved papers published between 2012 and 2021 in the field of Epigenetics. Since 2012, the number of publications related to this field has grown rapidly. The United States and China are at the fore-front of Epigenetics research and the cooperation between these two countries is relatively close. In this research field, most productive institutes and authors come from United States and China, and the high frequency of Biochemistry and Molecular Biology shows that they are hot subjects.
Habitação mínima contemporânea: estudo de caso do apartamento de 10 metros quadrados
Authors: Oliveira Filho Marco Antônio Martins de , Perrone Rafael Antônio Cunha , Silva Julia Rodrigues da 
Published: August 2024

A produção de habitação mínima contemporânea ganha força no mercado imobiliário paulistano a partir do começo do século XXI. A chegada de apartamentos denominados estúdios, com metragens entre 15 a 20 metros quadrados, está presente na grande maioria dos novos edifícios comercializados na contemporaneidade, especialmente aqueles localizados próximos a serviços de mobilidade urbana de massa. No entanto, um produto imobiliário ganhou atenção não só do mercado, mas também dos arquitetos e da sociedade civil. Apartamentos de 10 metros quadrados foram lançados para a comercialização na cidade de São Paulo se enquadrando como os menores apartamentos da América Latina. O objetivo central do trabalho busca entender como foi possível a sua aprovação legal, as condicionantes socioculturais capazes de gerar uma habitação tão reduzida e o desempenho dessa habitação a partir de conceitos qualificadores como uso, ergonomia e conforto. Nesse contexto, o estudo versa sobre a sua importância prática ao tentar estimular o debate sobre os apartamentos mínimos e o impacto dessa arquitetura, dialogando com a sua performance e usabilidade entre morador e obra arquitetônica. O trabalho possui a metodologia exploratória, a partir de busca referencias teóricos, e explicativa, pois identifica as causas dos fenômenos estudados, além de registrar e analisar os rebatimentos disso nos apartamentos mínimos. O estudo tem o intuito de diagnosticar a produção arquitetônica contemporânea e a qualidade de vida em que esses espaços podem oferecer nas novas formas de habitar.
Sustentabilidade e gestão das cidades históricas: Uma proposta a partir das ideias de Dennis Rodwell
Authors: Esteves Ivana Perucci , Souza Renato César Ferreira de 
Published: August 2024

O objetivo do presente ensaio é investigar a abordagem de Dennis Rodwell dentro do campo da teoria contemporânea restauro, destacando os pontos aplicáveis nas discussões sobre sustentabilidade e gestão das edificações históricas na atualidade no Brasil. Os debates da conservação do patrimônio histórico se iniciam no século XIX, no período do Renascimento Italiano. Eles evoluíram continuamente até a denominada Teoria Contemporânea do Restauro. Ponto relevante que tem sido discutido dentro desta corrente é a questão da sustentabilidade, que irá permear o presente estudo. A temática sustentabilidade, de um modo geral, tem sido amplamente debatida; o conceito se incorporou às discussões de arquitetura e, agora, também às ações de conservação em centros históricos.
Nesse contexto, Dennis Rodwell, arquiteto inglês, irá propor uma discussão em torno deste conceito em sua obra Conservação e Sustentabilidade em Cidades Históricas. O autor discute o tema da conservação de forma associada à sustentabilidade, apresentando, para tal, uma revisão histórica e uma análise crítica de estudos de caso de planos de intervenção na Europa, segunda metade do século XX. Com isso, ele defenderá a melhoria da qualidade destas propostas a partir da década de 70, quando o componente de sustentabilidade se inserir nestas discussões. Será produzida uma análise da aplicabilidade das ideias do autor em intervenções atuais em centros históricos brasileiros, a partir da proposição de um plano de ação genérico, para nortear intervenções e ações de gestão. Dessa forma, pretende-se abordar os estudos de Rodwell dentro da corrente contemporânea do restauro, entendendo suas potencialidades e fragilidades.
O edifício escolar expandido: análise projetual em Medellin nas escalas KM, M e CM.
Authors: Silva Leonardo Tadeu Kseib Coelho da , Lima Ana Gabriela Godinho 
Published: August 2024

Este estudo propõe uma análise da integração de escolas ao contexto urbano, com foco no Colégio Santo Domingo Savio - Antonio Derka, vencedor da Bienal XXII de 2010 na Colômbia e participante do Prêmio Latino-Americano de Arquitetura Rogério Salmona em 2014, sediado em Medellín, cidade reconhecida pela promoção de inovações urbanas, dentre as quais, nos últimos 20 anos destaca-se a política pública "Colegios de Calidad para Medellín". Essa iniciativa da Prefeitura de Medellín visou promover melhorias urbanas tendo como foco edifícios escolares, no momento em que a cidade era considerada a mais violenta do mundo. A análise baseia-se em uma metodologia organizada em três escalas: Quilômetro, Metro e Centímetro. Busca-se compreender as estratégias projetuais mobilizadas em cada escala. Os resultados apontam a relevância da localização estratégica da escola; as decisões de composição interna dos espaços que promovem articulação entre interior e exterior; e o desenho meticuloso dos ambientes externos e a conexão entre os diversos elementos do programa. O estudo visa contribuir com uma reflexão sobre o modo como as estratégias projetuais em edifícios escolares podem capacitar o edifício escolar a desempenhar um papel de articulação social e territorial capaz de promover a melhoria de qualidade de vida em territórios vulneráveis.
Kemampuan Pemahaman Mufrodat dalam Mata Pelajaran Bahasa Arab Melalui Metode Bernyanyi Siswa Kelas III MI Al-Huda Kesiman Trawas Mojokerto Tahun Ajaran 2022/2023
Authors: Vita Dwi Ariani  , Agus Tri Cahyo  
Published: August 2024

Penelitian ini dilatarbelakangi oleh siswa kelas III di MI Al-Huda Kesiman Mojokertomenganggap pembelajaran bahasa Arab itu sangat sulit. Pemahaman mufrodat menjadi salahsatu kunci dalam memahami materi bahasa Arab. Penelitian ini bertujuan untukmendeskripsikan hasil pemahaman mufrodat bahasa Arab melalui metode bernyanyi. Metodeyang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan jenis penelitian studikasus. Teknik pengumpulan data menggunakan teknik observasi, wawancara, dan dokumentasi.Adapun teknik analisisnya menggunakan kondensasi data, penyajian data, dan penarikankesimpulan. Hasil dari penelitian ini yaitu hasil pemahaman mufrodat bahasa Arab siswa kelasIII di MI Al-Huda Mojokerto melalui metode bernyanyi termasuk dalam tingkat pemahamanrendah yang berarti siswa mampu terjemah mulai dari terjemahan dalam arti sebenarnyasemisal, bahasa Arab ke bahasa Indonesia begitu sebaliknya. Hal tersebut dapat dilihat darinilai tes mufrodat. Selain itu, dapat dilihat juga ketika siswa diberi pertanyaan siswa berebutuntuk menjawab pertanyaan. Kesimpulan, melalui metode bernyanyi siswa dapat memahamimufrodat bahasa Arab dengan mudah.
Nilai-nilai Pendidikan Karakter dalam Novel Ayah Mengapa Aku Berbeda dan Relevansinya Dengan Buku Tematik Tema 2 SD/MI
Authors: Risma Faizah Yuniyanti  , Umi Rohmah  
Published: August 2024

Tujuan dari penelitian ini adalah untuk (1) mendeskripsikan nilai-nilai pendidikan karakter yang terkandung dalam novel Ayah Mengapa Aku Berbeda, (2) mendeskripsikan relevansi nilai-nilai pendidikan karakter dalam novel Ayah Mengapa Aku Berbeda pada buku Tematik tema 2 kelas 6 SD/MI. Penelitin ini merupakan penelitian kajian kepustakaan (library research) dengan menggunakan teknik analisis isi (content analysis). Dalam pengumpulan data peneliti menggunakan studi dokumentasi. Adapaun Langkah-langkah peneliti dalam menganalisi data sebagai berikut. (1) merumuskan tujuan analisis (2) pemilihan dan memfokukan pokok permasalahan (3) pengelompokan data sesuai permasalahan (4) penyajian data dalam bentuk diskripsi tentang nilai pendidikan karakter novel Ayah Mengapa Aku Berbeda (5) penganalisisan data kemudian ditarik kesimpulannya. Berdasarkan hasil pada penelitian ini menunjukkan (1) terdapat 7 nilai-nilai pendidikan karakter dalam novel Ayah Mengapa Aku Berbeda yaitu: toleransi, disiplin, kerja keras, menghargai prestasi, gemar membaca, peduli sosial dan tanggung jawab. (2) terdapat 7 nilai-nilai pendidikan karakter yang telah ditemukan peneliti dalam novel Ayah Mengapa Aku Berbeda dan ada relevansinya dengan buku Tematik tema 2 kelas 6 SD/MI.
Evaluation of an Enzymatic Hemoglobin A1C Assay
Authors: Majeed Numan , Kanani Fatima , Zubairi Adnan Mustafa 
Published: August 2024

Background: Different modalities have been designed for estimation of HbA1c, that include ion-exchange High Performance Liquid Chromatography (HPLC), immunoassay, enzymatic assays and capillary electrophoresis. Although based on different principles, these analytical processes have to exhibit robust performance so that an overall comparability of assay values can be ensured which are traceable to the available reference method.
Objectives: Objective of the study was to evaluate HbA1c measurement on Abbott Alinity C system against ion exchange high performance liquid chromatography.
Methods: We performed different experiments to evaluate measurement of HbA1c on Alinity C system by Abbott. These studies included accuracy, precision, linearity, carry over and method comparison in patients without any hemoglobin variants. Evaluation Protocol (EP) evaluator was used for data analysis.
Results: All the experiments passed the minimum passing criteria. All the claims by the vendor were successfully verified with and addition that vendor claims 12-hour stability while our study showed a stability of 18 hours. In precision the coefficient of variance in our experiment showed better results.
Conclusion: Alinity C system can be used reliably and efficiently for the assessment of HbA1c in patients without haemoglobin variants as our study did not include samples with variant hemoglobin.