bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Shelfbreak to Shoreline: Coastal Sea Level and Local Ocean Dynamics in the Northwest Atlantic
Authors: Camargo C. M. L. , Piecuch C. G. , Raubenheimer B. 
Published: July 2024

AbstractSea‐level change threatens the U.S. East Coast. Thus, it is important to understand the underlying causes, including ocean dynamics. Most past studies emphasized links between coastal sea level and local atmospheric variability or large‐scale circulation and climate, but possible relationships with local ocean currents over the shelf and slope remain largely unexplored. Here we use 7 years of in situ velocity and sea‐level data to quantify the relationship between northeastern U.S. coastal sea level and variable Shelfbreak Jet transport south of Nantucket Island. At timescales of 1–15 days, southern New England coastal sea level and transport vary in anti‐phase, with magnitude‐squared coherences of ∼0.5 and admittance amplitudes of ∼0.3 m Sv−1. These results are consistent with a dominant geostrophic balance between along‐shelf transport and coastal sea level, corroborating a hypothesis made decades ago that was not tested due to the lack of transport data.
Energy Conservation in the Cooling and Contracting Upper Mesosphere and Lower Thermosphere
Authors: Mlynczak Martin G. , Hunt Linda A. , Garcia Rolando , Lopez‐Puertas Manuel , Mertens Christopher J. , Nowak Nabil , Marshall B. Thomas 
Published: July 2024

AbstractTime series of radiative cooling of the upper mesosphere and lower thermosphere (UMLT) by carbon dioxide (CO2) are examined for evidence of trends over 20 years. Radiative cooling rates in K day−1 provided by the SABER instrument are converted to time series of infrared power radiated from three distinct layers between 0.1 hPa and 0.0001 hPa (65–105 km). Linear regression against time and a predictor for solar variability provides estimates of the trend in exiting longwave radiation (ELR) from these layers. Trends in ELR are not significantly different from zero at 95% or 99% confidence in each layer. These results demonstrate energy conservation in the UMLT on decadal time scales and show that the UMLT continues to radiate the same amount of energy it receives despite cooling and contracting over two decades. These results are enabled by the long‐term stability of the SABER instrument calibration.
Observed Increase in Tropical Cyclone‐Induced Sea Surface Cooling Near the U.S. Southeast Coast
Authors: John Effy B. , Balaguru Karthik , Leung L. Ruby , Hagos Samson M. , Hetland Robert D. 
Published: July 2024

AbstractTropical cyclones (TCs) induce substantial upper‐ocean mixing and upwelling, leading to sea surface cooling. In this study, we explore changes in TC‐induced cold wakes along the United States (U.S.) Southeast and Gulf Coasts during 1982–2020. Our study shows a significant increase in TC‐induced sea surface temperature (SST) cooling of about 0.20°C near the U.S. Southeast Coast over this period. However, for the U.S. Gulf Coast, trends in TC‐induced SST cooling are insignificant. Analysis of the large‐scale oceanic environments indicate that the increasing TC‐induced cold wakes near the Southeast coast have been predominantly caused by the cooling of subsurface waters in that region. This upper‐ocean change is attributed to the enhancement of surface pressure gradient across land‐sea boundary and the associated increase in alongshore winds over there. Further analysis with climate models reveals the important role of anthropogenic forcings in driving these changes in the atmospheric circulation response along the U.S. Southeast Coast.
Cloud Susceptibility to Aerosols: Comparing Cloud‐Appearance Versus Cloud‐Controlling Factors Regimes
Authors: Liu Jihu , Zhu Yannian , Wang Minghuai , Rosenfeld Daniel , Cao Yang , Yuan Tianle 
Published: July 2024

AbstractClouds can be classified into regimes based on their appearance or meteorological controlling factors. The cloud appearance regimes inherently include adjustments to aerosol effects, such as transitions between closed and open cells. Therefore, calculating cloud susceptibilities to aerosols for each cloud‐appearance regime individually and then aggregating them excludes much of the cloud adjustment component of the susceptibilities. In contrast, aggregating susceptibilities over regimes defined by cloud‐controlling factors includes the full effects of cloud adjustments. Here we compared the susceptibilities of the two kinds of cloud regimes and demonstrated this effect. Overall, increasing cloud droplet number concentration (Nd) consistently correlates to weaker precipitation, higher cloud fraction (CF), and reduced liquid water path, regardless of how the regime is defined. However, their susceptibilities to Nd aggregated over cloud‐appearance regimes are significantly lower than those aggregated over cloud‐controlling factors regimes, with lower‐tropospheric stability (LTS) serving as an example to define cloud‐controlling factors regimes. This underestimation is more pronounced for CF susceptibility, where the susceptibility for cloud appearance regimes is only 1/4 of the susceptibility for cloud controlling regimes. These findings imply that relying solely on cloud‐appearance regimes may underestimate the effective radiative forcing produced by cloud adjustment (ERFaci). Nevertheless, the substantial variability in the magnitude of cloud adjustment across appearance regimes at similar LTS also suggests that a single cloud‐controlling factor is not sufficient to fully separate cloud regimes to quantify cloud adjustment. Therefore, identifying a comprehensive set of cloud‐controlling factors is essential for accurately quantifying cloud adjustments in future studies.
Environmental and neurodevelopmental contributors to youth mental illness
Authors: Whittle Sarah , Zhang Lu , Rakesh Divyangana 
Published: July 2024

AbstractWhile a myriad of factors likely contribute to the development of mental illness in young people, the social environment (including early adverse experiences) in concert with neurodevelopmental alterations is undeniably important. A number of influential theories make predictions about how and why neurodevelopmental alterations may mediate or moderate the effects of the social environment on the emergence of mental illness. Here, we discuss current evidence supporting each of these theories. Although this area of research is rapidly growing, the body of evidence is still relatively limited. However, there exist some consistent findings, including increased striatal reactivity during positive affective processing and larger hippocampal volumes being associated with increased vulnerability or susceptibility to the effects of social environments on internalizing symptoms. Limited longitudinal work has investigated neurodevelopmental mechanisms linking the social environment with mental health. Drawing from human research and insights from animal studies, we propose an integrated mediation-moderation model and outline future research directions to advance the field.
USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway
Authors: Li Shuang , Yang Lina , Ding Xiaoyan , Sun Hongxiao , Dong Xiaolei , Yang Fanghao , Wang Mengjun , Zhang Huhu , Li Ya , Li Bing , Liu Chunyan 
Published: July 2024

AbstractThe regulatory significance of ubiquitin-specific peptidase 32 (USP32) in tumor is significant, nevertheless, the biological roles and regulatory mechanisms of USP32 in non-small cell lung cancer (NSCLC) remain unclear. According to our research, USP32 was strongly expressed in NSCLC cell lines and tissues and was linked to a bad prognosis for NSCLC patients. Interference with USP32 resulted in a significant inhibition of NSCLC cell proliferation, migration potential, and EMT development; on the other hand, USP32 overexpression had the opposite effect. To further elucidate the mechanism of action of USP32 in NSCLC, we screened H1299 cells for interacting proteins and found that USP32 interacts with BAG3 (Bcl2-associated athanogene 3) and deubiquitinates and stabilizes BAG3 in a deubiquitinating activity-dependent manner. Functionally, restoration of BAG3 expression abrogated the antitumor effects of USP32 silencing. Furthermore, USP32 increased the phosphorylation level of the RAF/MEK/ERK signaling pathway in NSCLC cells by stabilizing BAG3. In summary, these findings imply that USP32 is critical to the development of NSCLC and could offer a theoretical framework for the clinical diagnosis and management of NSCLC patients in the future.
Bad habits–good goals? Meta-analysis and translation of the habit construct to alcoholism
Authors: Giannone F. , Ebrahimi C. , Endrass T. , Hansson A. C. , Schlagenhauf F. , Sommer W. H. 
Published: July 2024

AbstractExcessive alcohol consumption remains a global public health crisis, with millions suffering from alcohol use disorder (AUD, or simply “alcoholism”), leading to significantly reduced life expectancy. This review examines the interplay between habitual and goal-directed behaviors and the associated neurobiological changes induced by chronic alcohol exposure. Contrary to a strict habit-goal dichotomy, our meta-analysis of the published animal experiments combined with a review of human studies reveals a nuanced transition between these behavioral control systems, emphasizing the need for refined terminology to capture the probabilistic nature of decision biases in individuals with a history of chronic alcohol exposure. Furthermore, we distinguish habitual responding from compulsivity, viewing them as separate entities with diverse roles throughout the stages of the addiction cycle. By addressing species-specific differences and translational challenges in habit research, we provide insights to enhance future investigations and inform strategies for combatting AUD.
Inclusion of clinical photographs with general dental practitioner electronic referrals of patients with oral mucosal disease to secondary care: a service review
Authors: Webb Leah R. , Simms Melanie L. , Atkin Philip A. 
Published: July 2024

AbstractIntroduction This service evaluation reviewed how the inclusion of photographs in dentist referrals to an oral medicine specialist service can improve the service for triage, prioritisation and diagnosis.Materials and methods Data were prospectively collected from e-referrals over a four-month period. Any change in appointment prioritisation resulting from review of photographs at the vetting stage was recorded.Results Only 29.5% (82 of 367) of referrals included a photograph. Of these, 5% were ‘rejected with advice' since the photograph indicated the patient did not require a secondary care appointment. Additionally, 14% of all referrals were upgraded in urgency, five of which were due to concerns of malignancy, and three of five were upgraded solely based on the photographs as they showed features of possible malignancy, where the written element of the referral did not describe nor raise such concerns.Discussion and conclusions Including a photograph with a referral can often make up for inaccurate or insufficient written content, allowing appropriate and safe prioritisation, especially where the referrer has failed to recognise possible malignancy. Photographs can also prevent unnecessary referral upgrades, ensure an appointment is necessary and can be invaluable as a baseline comparator.
Human papillomavirus-associated head and neck squamous cell carcinoma cells lose viability during triggered myocyte lineage differentiation
Authors: Gendreizig Sarah , Martínez-Ruiz Laura , López-Rodríguez Alba , Pabla Harkiren , Hose Leonie , Brasch Frank , Busche Tobias , Escames Germaine , Sudhoff Holger , Scholtz Lars Uwe , Todt Ingo , Oppel Felix 
Published: July 2024

AbstractHead and neck squamous cell carcinoma (HNSCC) is a highly malignant disease, and death rates have remained at approximately 50% for decades. New tumor-targeting strategies are desperately needed, and a previous report indicated the triggered differentiation of HPV-negative HNSCC cells to confer therapeutic benefits. Using patient-derived tumor cells, we created a similar HNSCC differentiation model of HPV+ tumor cells from two patients. We observed a loss of malignant characteristics in differentiating cell culture conditions, including irregularly enlarged cell morphology, cell cycle arrest with downregulation of Ki67, and reduced cell viability. RNA-Seq showed myocyte-like differentiation with upregulation of markers of myofibril assembly. Immunofluorescence staining of differentiated and undifferentiated primary HPV+ HNSCC cells confirmed an upregulation of these markers and the formation of parallel actin fibers reminiscent of myoblast-lineage cells. Moreover, immunofluorescence of HPV+ tumor tissue revealed areas of cells co-expressing the identified markers of myofibril assembly, HPV surrogate marker p16, and stress-associated basal keratinocyte marker KRT17, indicating that the observed myocyte-like in vitro differentiation occurs in human tissue. We are the first to report that carcinoma cells can undergo a triggered myocyte-like differentiation, and our study suggests that the targeted differentiation of HPV+ HNSCCs might be therapeutically valuable.
Pseudoirreversible inhibition elicits persistent efficacy of a sphingosine 1-phosphate receptor 1 antagonist
Authors: Maruyama Yuya , Ohsawa Yusuke , Suzuki Takayuki , Yamauchi Yuko , Ohno Kohsuke , Inoue Hitoshi , Yamamoto Akitoshi , Hayashi Morimichi , Okuhara Yuji , Muramatsu Wataru , Namiki Kano , Hagiwara Naho , Miyauchi Maki , Miyao Takahisa , Ishikawa Tatsuya , Horie Kenta , Hayama Mio , Akiyama Nobuko , Hirokawa Takatsugu , Akiyama Taishin 
Published: July 2024

AbstractSphingosine 1-phosphate receptor 1 (S1PR1), a G protein-coupled receptor, is required for lymphocyte trafficking, and is a promising therapeutic target in inflammatory diseases. Here, we synthesize a competitive S1PR1 antagonist, KSI-6666, that effectively suppresses pathogenic inflammation. Metadynamics simulations suggest that the interaction of KSI-6666 with a methionine residue Met124 in the ligand-binding pocket of S1PR1 may inhibit the dissociation of KSI-6666 from S1PR1. Consistently, in vitro functional and mutational analyses reveal that KSI-6666 causes pseudoirreversible inhibition of S1PR1, dependent on the Met124 of the protein and substituents on the distal benzene ring of KSI-6666. Moreover, in vivo study suggests that this pseudoirreversible inhibition is responsible for the persistent activity of KSI-6666.
Combined inhibition of KRASG12C and mTORC1 kinase is synergistic in non-small cell lung cancer
Authors: Kitai Hidenori , Choi Philip H. , Yang Yu C. , Boyer Jacob A. , Whaley Adele , Pancholi Priya , Thant Claire , Reiter Jason , Chen Kevin , Markov Vladimir , Taniguchi Hirokazu , Yamaguchi Rui , Ebi Hiromichi , Evans James , Jiang Jingjing , Lee Bianca , Wildes David , de Stanchina Elisa , Smith Jacqueline A. M. , Singh Mallika , Rosen Neal 
Published: July 2024

AbstractCurrent KRASG12C (OFF) inhibitors that target inactive GDP-bound KRASG12C cause responses in less than half of patients and these responses are not durable. A class of RASG12C (ON) inhibitors that targets active GTP-bound KRASG12C blocks ERK signaling more potently than the inactive-state inhibitors. Sensitivity to either class of agents is strongly correlated with inhibition of mTORC1 activity. We have previously shown that PI3K/mTOR and ERK-signaling pathways converge on key cellular processes and that inhibition of both pathways is required for inhibition of these processes and for significant antitumor activity. We find here that the combination of a KRASG12C inhibitor with a selective mTORC1 kinase inhibitor causes synergistic inhibition of Cyclin D1 expression and cap-dependent translation. Moreover, BIM upregulation by KRASG12C inhibition and inhibition of MCL-1 expression by the mTORC1 inhibitor are both required to induce significant cell death. In vivo, this combination causes deep, durable tumor regressions and is well tolerated. This study suggests that the ERK and PI3K/mTOR pathways each mitigate the effects of inhibition of the other and that combinatorial inhibition is a potential strategy for treating KRASG12C-dependent lung cancer.
Water training initiates spatially regulated microstructures with competitive mechanics in hydroadaptive polymers
Authors: Chen Wenbo , Huang Caoxing , Biehl Philip , Zhang Kai 
Published: July 2024

AbstractThe strategy using water as a medium for dynamic modulation of competitive plasticity and viscoelasticity provides a unique perspective to attain adaptive materials. We reveal sustainable polymers, herein cellulose phenoxyacetate as a typical example, with unusual water-responsive dual-mechanic functionalities addressed via a chronological water training strategy. The temporal significance of such water-responsive mechanical behaviors becomes apparent considering that a mere 3-minute exposure or a prolonged 3-hour exposure to water induced different types of mechano-responsiveness. This endows the materials with multiple recoverable shape-changes during water and air training, and consequently even underlines the switchability between the pre-loaded stable water shapes (> 20 months) and the sequentially fixed air shapes. Our discovery exploits the competitive mechanics initiated by water training, enabling polymers with spatially regulated microstructures via their inherently distinct mechanical properties. Insights into the molecular changes represents a considerable fundamental innovation, can be broadly applicable to a diverse array of hydroadaptive polymers.
Radiative cooling assisted self-sustaining and highly efficient moisture energy harvesting
Authors: Guo Chenyue , Tang Huajie , Wang Pengfei , Xu Qihao , Pan Haodan , Zhao Xinyu , Fan Fan , Li Tingxian , Zhao Dongliang 
Published: July 2024

AbstractHarvesting electricity from ubiquitous water vapor represents a promising route to alleviate the energy crisis. However, existing studies rarely comprehensively consider the impact of natural environmental fluctuations on electrical output. Here, we demonstrate a bilayer polymer enabling self-sustaining and highly efficient moisture-electric generation from the hydrological cycle by establishing a stable internal directed water/ion flow through thermal exchange with the ambient environment. Specifically, the radiative cooling effect of the hydrophobic top layer prevents the excessive daytime evaporation from solar absorption while accelerating nighttime moisture sorption. The introduction of LiCl into the bottom hygroscopic ionic hydrogel enhances moisture sorption capacity and facilitates ion transport, thus ensuring efficient energy conversion. A single device unit (1 cm2) can continuously generate a voltage of ~0.88 V and a current of ~306 μA, delivering a maximum power density of ~51 μW cm−2 at 25 °C and 70% relative humidity (RH). The device has been demonstrated to operate steadily outdoors for continuous 6 days.
Electron iso-density surfaces provide a thermodynamically consistent representation of atomic and molecular surfaces
Authors: Alibakhshi Amin , Schäfer Lars V. 
Published: July 2024

AbstractThe surface area of atoms and molecules plays a crucial role in shaping many physiochemical properties of materials. Despite its fundamental importance, precisely defining atomic and molecular surfaces has long been a puzzle. Among the available definitions, a straightforward and elegant approach by Bader describes a molecular surface as an iso-density surface beyond which the electron density drops below a certain cut-off. However, so far neither this theory nor a decisive value for the density cut-off have been amenable to experimental verification due to the limitations of conventional experimental methods. In the present study, we employ a state-of-the-art experimental method based on the recently developed concept of thermodynamically effective (TE) surfaces to tackle this longstanding problem. By studying a set of 104 molecules, a close to perfect agreement between quantum chemical evaluations of iso-density surfaces contoured at a cut-off density of 0.0016 a.u. and experimental results obtained via thermodynamic phase change data is demonstrated, with a mean unsigned percentage deviation of 1.6% and a correlation coefficient of 0.995. Accordingly, we suggest the iso-density surface contoured at an electron density value of 0.0016 a.u. as a representation of the surface of atoms and molecules.
Microplastic detection and remediation through efficient interfacial solar evaporation for immaculate water production
Authors: Yu Zhen , Li Yang , Zhang Yaoxin , Xu Ping , Lv Chade , Li Wulong , Maryam Bushra , Liu Xianhua , Tan Swee Ching 
Published: July 2024

AbstractFreshwater scarcity and microplastics (MPs) pollution are two concerning and intertwined global challenges. In this work, we propose a “one stone kills two birds” strategy by employing an interfacial solar evaporation platform (ISEP) combined with a MPs adsorbent. This strategy aims to produce clean water and simultaneously enhance MPs removal. Unlike traditional predecessors, our ISEP generates condensed water free from MPs contamination. Additionally, the photothermally driven interfacial separation process significantly improves the MPs removal performance. We observed a removal ratio increase of up to 5.5 times compared to previously reported MPs adsorbents. Thus, our rationally-designed ISEP holds promising potential to not only mitigate the existing water scarcity issue but also remediate MPs pollution in natural water environments.
IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer
Authors: van Baarle Lies , De Simone Veronica , Schneider Linda , Santhosh Sneha , Abdurahiman Saeed , Biscu Francesca , Schneider Reiner , Zanoletti Lisa , Siqueira de Mello Renata , Verbandt Sara , Hu Zedong , Stakenborg Michelle , Ke Bo-Jun , Stakenborg Nathalie , Salvador Laureano Raquel , García-Reyes Balbina , Henn Jonas , Toma Marieta , Vanmechelen Maxime , Boeckxstaens Guy , De Smet Frederik , Garg Abhishek D. , Ibiza Sales , Tejpar Sabine , Wehner Sven , Matteoli Gianluca 
Published: July 2024

AbstractEnteric glia have been recently recognized as key components of the colonic tumor microenvironment indicating their potential role in colorectal cancer pathogenesis. Although enteric glia modulate immune responses in other intestinal diseases, their interaction with the colorectal cancer immune cell compartment remains unclear. Through a combination of single-cell and bulk RNA-sequencing, both in murine models and patients, here we find that enteric glia acquire an immunomodulatory phenotype by bi-directional communication with tumor-infiltrating monocytes. The latter direct a reactive enteric glial cell phenotypic and functional switch via glial IL-1R signaling. In turn, tumor glia promote monocyte differentiation towards pro-tumorigenic SPP1+ tumor-associated macrophages by IL-6 release. Enteric glia cell abundancy correlates with worse disease outcomes in preclinical models and colorectal cancer patients. Thereby, our study reveals a neuroimmune interaction between enteric glia and tumor-associated macrophages in the colorectal tumor microenvironment, providing insights into colorectal cancer pathogenesis.