bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drillstring Mechanics Model for Surveillance, Root Cause Analysis, and Mitigation of Torsional and Axial Vibrations
Authors: Ertas Deniz , Bailey Jeffrey R. , Wang Lei , Pastusek Paul E. 
Published: January 2013

Abstract
Vibrations have been identified as one of the most frequent and persistent performance limiters by limiting weight-on-bit, rate of penetration, or borehole quality even when they may be low enough not to cause damage to downhole tools and equipment.
A general purpose drillstring mechanics model has been developed to analyze axial and torsional vibrations in the frequency domain and provide vibration indices indicative of dysfunction in these modes. The model utilizes transfer matrices to solve for harmonic perturbations around a baseline solution obtained from a torque-and-drag type analysis, and accounts for effects of well path, tool joints, viscous damping due to the drilling fluid, surface boundary conditions, bit characteristics, and special vibration mitigation tools. The model supports workflows for real-time vibration surveillance as well as post-drill root cause analysis and well redesign. For example, real-time stick/slip severity monitoring is enabled using 1-second surface measurements. As a well redesign tool, a large number of design alternatives can be quickly evaluated to mitigate vibrations.
Case studies utilizing high-frequency surface/downhole drilling mechanics data validated the model and identified three types of torsional dysfunctions with distinct signatures and mitigators: Unstable Stick/Slip, an instability associated mostly with the lowest-frequency torsional resonance of the drillstring; Bit/Bottomhole Assembly (BHA) Stall, intermittent, sudden mechanical jamming at the bottom of the drillstring; and Synchronous Torsional Oscillation, the amplification of periodic excitations at torsional resonances of the drillstring. In one case study, the stick/slip surveillance tool was superior to realtime downhole measurements in lag time, bandwidth, and accuracy. In another case, the root cause of prevalent Unstable Stick/Slip was identified as velocity-weakening aggressiveness of the bit. Among redesign options using a topdrive controller tuned to damp out the lowest-frequency torsional resonance was deemed most effective. One such controller was evaluated in the field and was very effective at mitigating stick/slip in subsequent wells.
Microstructures and electrode performances of Mg50Ni(50-X)Pdx alloys
Authors: Santos Sydney , Castro José , Ticianelli Edson 
Published: January 2013

Abstract
Magnesium and several of its alloys can absorb large amounts of hydrogen. This feature is desirable for several technological applications such as solid state hydrogen storage tanks and anodes of nickel-metal hydride (Ni-MH) batteries. For the latter, Mg-Ni alloys are considered very promising due to their high discharge capacities. Conversely, the low stability of Mg-Ni alloys in alkaline electrolytes have hindered their practical use. In the present manuscript, the effects of palladium black addition on the structure and electrochemical properties of the Mg50Ni50 (in at.%) alloy were investigated. The studied ternary alloys have general composition of Mg50Ni(50-x)Pdx, with 0 ≤ x ≤ 5 (in at.%). These alloys were synthesized by mechanical alloying from pure elements. The alloy powders were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray absorption spectroscopy (XAS) while their electrode performances were evaluated by galvanostatic cycles of charge and discharge. The investigated alloys have multi-phase structures composed of amorphous and nanocrystalline phases, with nano-grain sizes of nearly 5 nm. Concerning the electrode performance, the best results were attained by the Mg50Ni47.5Pd2.5 alloy, which kept a high discharge capacity and improved the cycling stability.
Synthesis, reactions and antineoplastic activity of 3-(2-oxo-2H-chromen-3-yl)-2-oxo-2H,5H-pyrano[3,2-c]chromene derivatives
Authors: Gašparová Renata , Koiš Pavol , Lácová Margita , Kováčová Silvia , Boháč Andrej 
Published: January 2013

Abstract
The key 3-(2-oxo-2H-chromen-3-yl)-2-oxo-2H,5H-pyrano[3,2-c]chromen-5-yl acetates 3 were synthesized in high yields by cyclocondensation of 4-oxo-4H-chromen-3-carbaldehydes 1 with coumarin-3-acetic acids 2 under mild conditions. The reaction pathway involves aldol condensation and subsequent intramolecular lactonization to afford 2-oxo-2H,5H-pyrano[3,2-c]chromene skeleton 3. Further treatment of acetates 3 with alcohols, water or nitrogen containing compounds led to 5-alkoxy-, 5-hydroxy- or 5-acylamino-2H,5H-pyrano[3,2-c]chromen-2-ones 4-6 via nucleophilic substitution of acetyloxy group at C-5. Acetates and hydroxyl derivatives 3 and 5 undergo facile rearrangement in an acid medium yielding 5-hydroxypyrano[2,3-b]chromen-2(10aH)-ones 7.

Twelve prepared compounds were evaluated on their antineoplastic activities on 60 human tumour cell line panels in NCI USA. The obtained biological results confirmed that 3-(2-oxo-2H-chromen-3-yl)-2H,5H-pyrano[3,2-c]chromen-2-one represents a new leading skeleton suitable for further antitumour activity study.
Fullerenes patched by flowers
Authors: Pop Raluca , Medeleanu Mihai , Diudea Mircea , Szefler Beata , Cioslowski Jerzy 
Published: January 2013

Abstract
Stability measures, such as the total energy and the HOMO-LUMO gap, calculated at the Hartree-Fock and DFT levels of theory, and the aromatic character of five circulenes/flowers with a hexagonal core and petals consisting of 5-, 6- and 7-membered rings are investigated. Geometric (HOMA) and magnetic (NICS) criteria are used to estimate the local aromatic character of every ring of the investigated circulenes. The local aromaticity of the coronene and sumanene patches in two tetrahedrally spanned fullerenes were calculated and compared with the HOMA and NICS values of the corresponding isolated circulenes.
Spectrophotometric and voltammetric characterization of a novel selective electroactive chemosensor for Mg2+
Authors: Zor Erhan , Saf Ahmet , Bingol Haluk 
Published: January 2013

Abstract
A novel azocalix[4]arene derivative, 5,11,17,23-tetrakis[(acetophenone)azo]-25,26,27,28-tetrahydroxycalix[4]arene (APC4), containing acetophenone azo groups at the upper rim was synthesized as a chemosensor. Its binding and sensing properties with alkali and alkaline earth metal ions (Li+, Na+, K+, Rb+, Cs+, Mg2+, Ca2+, Sr2+, Ba2+) were investigated by UV-vis spectrophotometric and voltammetric techniques. The stoichiometric ratio and the association constant were determined spectrophotometrically as 1:1 and (1.94±0.31)×105 L mol−1 for the complex between Mg2+ and the chemosensor, respectively. Moreover, it was shown that the interaction between Mg2+ and the APC4 occurred by means of the phenol groups at the lower rim by voltammetric methods. The results of spectrophotometric and voltammetric experiments showed that the chromogenic chemosensor has high selectivity towards Mg2+ among the other used metal ions, especially the interfering Ca2+ ion.
Can Patients with Common Variable Immunodeficiency Have Allergic Rhinitis?
Authors: Agondi Rosana C. , Barros Myrthes T. , Kokron Cristina M. , Cohon Andrea , Oliveira Ana K.B. , Kalil Jorge , Giavina-Bianchi Pedro 
Published: January 2013

Background Rhinosinusitis is highly prevalent in patients with common variable immunodeficiency (CVID), and probably allergic rhinitis (AR) may be masked by a history of repeated respiratory infections. The diagnosis of AR is based on the patient's symptoms and detection of specific immunoglobulin E (IgE) to aeroallergens. This study was designed to identify rhinitis of probable allergic cause in patients with CVID. Methods This study included 72 adult CVID patients. The patients were divided into three groups according to their history: suggestive of AR, nonallergic rhinitis, and without rhinitis. They were tested for total and specific IgE (in vivo and in vitro). Results The patients’ mean age was 38.2 years. A history of chronic rhinitis was observed in 59 (81.9%) of the cases, 31 of which (43%) had a history suggestive of AR. Patients with a history of rhinitis (whether allergic or nonallergic) presented an earlier onset of symptoms and diagnosis of CVID. Total IgE was undetectable in 86.1% of patients. AR was confirmed by detection of specific IgE to aeroallergens in only 5.6% of the patients. Conclusion In CVID patients, chronic rhinitis may be allergic, because many have personal and family histories suggestive of atopy. However, in this study, allergy was confirmed by specific IgE detection in only 5.6% of cases. CVID patients with a history suggestive of AR commonly present negative results on traditional testing, so additional experiments may be necessary. One suggestion for the investigation of AR in CVID patients would be nasal provocation with the most prevalent allergens.
Le coton bio-équitable du Mali : matière à équivoque
Authors: Rubino Roberta 
Published: January 2013

Le commerce équitable est généralement perçu comme une pratique hybride entre le don et le marché, levier de développement pour les pays du Sud. Cet article, à travers une étude de cas réalisée au Mali, interroge chacune des ces interprétations : il questionne la performance d’un commerce qui bien qu’ « équitable » reste enveloppé dans une économie de marché et, en même temps, il interroge les implications liées à la part du don qu’il contient. Ce genre d’analyse vise à mettre en évidence les limites du commerce équitable dues aux implicites politico-culturels dont il est porteur.
Effets directs du développement financier sur la pauvreté : validation empirique sur un panel de pays à bas et moyen revenu
Authors: Boukhatem Jamel , Mokrani Bochra 
Published: January 2013

L’objet de cet article consiste à tester empiriquement l’existence des effets directs du développement financier sur la réduction de la pauvreté pour un échantillon de 67 pays à bas et moyen revenu sur la période 1986-2009. Les résultats obtenus montrent qu’indépendamment de la méthode économétrique appliquée, le développement financier contribue directement à la réduction de la pauvreté. En revanche, l’instabilité liée au développement financier pénaliserait les populations pauvres et anéantirait les effets positifs liés au développement financier. Faut-il donc trouver un arbitrage entre le développement financier et l’instabilité financière afin d’assurer une croissance pro-pauvres ?
L'interprétation comme activité de travail : matérialité et signification de l'œuvre
Authors: Hénaut Léonie 
Published: January 2013

Résumé Cet article interroge le lien entre la matérialité d’une œuvre d’art – son aspect, son état matériel – et la signification qu’on lui attribue. En étudiant les interactions ayant lieu entre conservateurs et restaurateurs, à l’occasion de leur restauration, nous montrons comment la matérialité infléchit le processus d’interprétation. D’une part, les acteurs en présence s’appuient sur la matérialité du tableau pour mettre en cohérence les différents dispositifs d’interprétation disponibles et déterminer collectivement le sens dit « original » de l’œuvre, c’est-à-dire celui qui est le plus fidèle à l’intention de l’artiste. D’autre part, par sa présence, le tableau participe activement à la production de son nouveau sens.
Spatial Coupling of JNK Activation to the B Cell Antigen Receptor by Tyrosine-Phosphorylated Ezrin
Authors: Parameswaran Neetha , Enyindah-Asonye Gospel , Bagheri Nayer , Shah Neilay B. , Gupta Neetu 
Published: January 2013

AbstractThe ezrin-radixin-moesin proteins regulate B lymphocyte activation via their effect on BCR diffusion and microclustering. This relies on their ability to dynamically tether the plasma membrane with actin filaments that is in turn facilitated by phosphorylation of the conserved threonine residue in the actin-binding domain. In this study, we describe a novel function of ezrin in regulating JNK activation that is mediated by phosphorylation of a tyrosine (Y353) residue that is unconserved with moesin and radixin. BCR, but not CD40, TLR4, or CXCR5 stimulation, induced phosphorylation of ezrin at Y353 in mouse splenic B cells. Ezrin existed in a preformed complex with Syk in unstimulated B cells and underwent Syk-dependent phosphorylation upon anti-IgM stimulation. Y353-phosphorylated ezrin colocalized with the BCR within minutes of stimulation and cotrafficked with the endocytosed BCRs through the early and late endosomes. The T567 residue of ezrin was rephosphorylated in late endosomes and at the plasma membrane at later times of BCR stimulation. Expression of a nonphosphorylatable Y353F mutant of ezrin specifically impaired JNK activation. BCR crosslinking induced the association of Y353-phosphorylated ezrin with JNK and its kinase MAPKK7, as well as spatial colocalization with phosphorylated JNK in the endosomes. The yellow fluorescent protein–tagged Y353F mutant displayed reduced colocalization with the endocytosed BCR as compared with wild-type ezrin-yellow fluorescent protein. Taken together, our data identify a novel role for ezrin as a spatial adaptor that couples JNK signaling components to the BCR signalosome, thus facilitating JNK activation.
Virus-Encoded TLR Ligands Reveal Divergent Functional Responses of Mononuclear Phagocytes in Pathogenic Simian Immunodeficiency Virus Infection
Authors: Wonderlich Elizabeth R. , Wijewardana Viskam , Liu Xiangdong , Barratt-Boyes Simon M. 
Published: January 2013

Abstract
The role of mononuclear phagocytes in the pathogenesis or control of HIV infection is unclear. In this study, we monitored the dynamics and function of dendritic cells (DC) and monocytes/macrophages in rhesus macaques acutely infected with pathogenic SIVmac251 with and without antiretroviral therapy (ART). SIV infection was associated with monocyte mobilization and recruitment of plasmacytoid DC (pDC) and macrophages to lymph nodes, which did not occur with ART treatment. SIVmac251 single-stranded RNA encoded several uridine-rich sequences that were potent TLR7/8 ligands in mononuclear phagocytes of naive animals, stimulating myeloid DC (mDC) and monocytes to produce TNF-α and pDC and macrophages to produce both TNF-α and IFN-α. Following SIV infection, pDC and monocytes/macrophages rapidly became hyporesponsive to stimulation with SIV-encoded TLR ligands and influenza virus, a condition that was reversed by ART. The loss of pDC and macrophage function was associated with a profound but transient block in the capacity of lymph node cells to secrete IFN-α upon stimulation. In contrast to pDC and monocytes/macrophages, mDC increased TNF-α production in response to stimulation following acute infection. Moreover, SIV-infected rhesus macaques with stable infection had increased mDC responsiveness to SIV-encoded TLR ligands and influenza virus at set point, whereas animals that progressed rapidly to AIDS had reduced mDC responsiveness. These findings indicate that SIV encodes immunostimulatory TLR ligands and that pDC, mDC, and monocytes/macrophages respond to these ligands differently as a function of SIV infection. The data also suggest that increased responsiveness of mDC to stimulation following SIV infection may be beneficial to the host.
Subepithelial Vocal Fold Cyst: A Pearl on a String?
Authors: Nerurkar Nupur , Shukla Sunita Chhapola 
Published: January 2013

ABSTRACTObjectiveSubepithelial vocal fold cyst (SEVFC) is an epithelium lined sac within the lamina propria. These cysts are of two histologic types: Mucous retention cyst and epidermoid cyst. Rupture of the cyst during surgical excision and incomplete cyst wall removal with consequent recurrence of the cyst is not an infrequent problem. While performing cold-steel blunt microflap surgery for SEVFC, the first author observed thick fibrotic bands at the 12 and 6 o'clock position in all the cases, giving the appearance of a ‘pearl (cyst) on a string (fibrotic bands)’. In most cases of cyst rupture, it took place during dissection of these bands. The aim of our study was to see if there was any significant difference in rupture and recurrence rate by sharp versus blunt dissection of these fibrotic bands.Study designRetrospective nonrandomized cohort comparison.Materials and methodsFifty-nine subepithelial cysts were operated by microflap technique. The first 26 cysts were taken in alternation for blunt vs sharp dissection of the fibrotic bands. As the results of sharp dissection were better, the subsequent 33 cysts were operated with sharp dissection of the anterior and posterior bands.ResultsSharp dissection of the anterior and posterior bands during microflap dissection reduced the incidence of cyst rupture (p = 0.006) and recurrence (p = 0.007) of cyst formation.ConclusionSEVFC are anchored by thick fibrotic bands at the 12 and 6 o'clock position giving it the appearance of a ‘pearl (cyst) on a string (fibrotic bands)’. Sharp dissection of these bands during microflap dissection reduces the incidence of cyst rupture and recurrence.How to cite this articleNerurkar NK, Shukla SC. Subepithelial Vocal Fold Cyst: A Pearl on a String? Int J Phonosurg and Laryngol 2012;2(2):53-56.
Supraglottic Laryngeal Paraganglioma: A Rare Clinical Entity managed by Lateral Pharyngotomy Approach
Authors: Naik Sudhir M 
Published: January 2013

ABSTRACT

Background/objectives
Laryngeal paragangliomas are benign slow growing tumors with symptoms resembling squamous cell carcinoma. Hoarseness or dysphasia is the commonest presenting symptom and usually it presents as a submucosal mass on laryngoscopy. A total of 90% of these tumors occur in the supraglottic larynx and the rest in the glottis and the subglottic region. Functional activity is seen in a few (2.9%), none are associated with paraneoplastic syndromes.

Setting
Department of Head and Neck Oncosurgery, Kidwai Memorial Institute of Oncology, Bengaluru.

Case report
A 35-year-old male presented to us with hoarseness of voice since 4 months duration. Contrast arteriography demonstrated that the left superior thyroid artery supplied greater than 80% of the blood supply to the laryngeal mass. Superselective embolization was done from the right femoral under local anesthesia and sedation which was uneventful.

Intervention
The tumor was excised from lateral pharyngotomy approach with an elective tracheostomy. Microscopy suggested it to be paraganglioma and immunohistochemistry confirmed it.

Conclusion
Complete surgical resection or partial laryngectomy with meticulous dissection of surrounding tissues and preservation of neurovascular structures give an excellent prognosis as far as oncological clearance is concerned. Malignant paragangliomas of the larynx are rare and a major meta-analysis is necessary to provide a true biological behavior of this tumor.

How to cite this article
Naik SM. Supraglottic Laryngeal Paraganglioma: A Rare Clinical Entity managed by Lateral Pharyngotomy Approach. Int J Phonosurg Laryngol 2012;2(2): 69-73.
Near Total Laryngectomy and Laryngopharyngectomy
Authors: Varghese Bipin Thomas 
Published: January 2013

ABSTRACT
Author describes the technical modifications in near total laryngectomy (NTL) that helps in reducing wound-related morbidity especially in a salvage setting. The improvization described ensures optimal preservation of normal structures thereby enhancing the functional results of NTL.

How to cite this article
Varghese BT. Near Total Laryngectomy and Laryngopharyngectomy. Int J Phonosurg Laryngol 2012;2(2):77-78.
Lipomas of Larynx: The Rare Entities
Authors: Megalamani Somanath B , Gadag Ravindra , Raza A , Satish A 
Published: January 2013

ABSTRACT
Lipoma is the commonest soft tissue tumor arising anywhere in the body, but its occurrence in the larynx is relatively rare. We present a rarest case of lipoma with cartilaginous metaplasia arising from the larynx just above the anterior commissure. The second case report is about a large spindle cell lipoma of larynx presented with stridor.

How to cite this article
Megalamani SB, Gadag R, Raza A, Satish A. Lipomas of Larynx: The Rare Entities. Int J Phonosurg Laryngol 2012;2(2):79-81.
An Unusual cause for Vocal Cord Palsy: Case Record
Authors: Divya GM , Varghese Bipin Thomas , Sebastian Paul 
Published: January 2013

ABSTRACT

Objectives
We report a case of granulomatous lesion infiltrating the recurrent laryngeal nerve to produce vocal cord palsy, the diagnostic dilemma posed by it and its management.

Materials and methods
Clinical documentation of a 52-yearold man who presented with hoarseness of 3 months duration is presented. The clinical examination revealed immobile left vocal cord and a bulky (Lt) ventricular band with a suspicious ulcer on its posterior aspect. A computed tomographic (CT) scan of the neck and chest revealed a 1 × 1 cm nodular lesion in the tracheoesophageal groove.

Conclusion
Causes for vocal cord palsies are wide ranging and predominantly include malignant infiltration of the vagus or the recurrent laryngeal nerve. The anatomical site of involvement can be clinically and radiologically assessed with ease. Vocal cord palsy due to recurrent laryngeal nerve involvement by a granulomatous lesion is an unreported phenomenon and we believe that this is the first case to be reported in literature.

Summary
An unusual case of recurrent laryngeal nerve granuloma is reported with the diagnostic dilemma that it presented. This was successfully managed by surgical excision and postoperative antituberculosis treatment.

How to cite this article
Varghese BT, Sebastian P, Divya GM. An Unusual cause for Vocal Cord Palsy: Case Record. Int J Phonosurg Laryngol 2012;2(2):88-90.
Long Stem Cemented Revision Arthroplasty for Aseptic Loosening in Elderly Patients Produces Good Results, despite Significant Bone Loss
Authors: Harrison Timothy , Jones Henry Wynn , Darrah Clare , Warriner Gary , Tucker J. Keith 
Published: January 2013

We assessed the results of long cemented stems in patients over 65 undergoing a first time revision hip arthroplasty for aseptic loosening. 103 patients were followed up for a minimum of five years after revision surgery; 45% had EndoKlinik C grade preoperative bone loss. At final follow-up 31 patients had died, all but one with the prosthesis in situ. There were 71 revisions alive, one had been revised for a peri-prosthetic fracture. Of the 45 that had radiographs at a minimum of five years, three stems were probably or definitely loose according to the Harris classification. There was 92% patient satisfaction and a mean Oxford Hip Score (OHS) of 25/60 in the 59 patients that had not been revised and had full clinical follow-up. Long-stem cemented revisions for aseptic loosening in elderly patients allow immediate postoperative weight bearing and have good radiological and clinical outcomes.
Asportazione Laparoscopica di Rene Policistico per via Retroperitoneale: Note di Tecnica
Authors: Parma Paolo , Samuelli Alessandro , Dall'Oglio Bruno 
Published: January 2013

Introduction We present our technique of laparoscopic nephrectomy with intact specimen extraction for patient with autosomal dominant polycystic kidney disease (ADPKD). Materials and Methods A 5-port retroperitoneal laparoscopic approach was used to dissect the involved kidney, which was then removed intact through a Gibson modified incision. Results The operative time was 110 minutes. Blood loss accounted for 50 mL. There were no intra or post-operative complications. The hospital stay was 4 days. Conclusions Laparoscopic nephrectomy for ADKD is technically feasible and clinically safe. The advantages of these technique compared to transperitoneal laparoscopy are the quick access to the hilar vessels and the strict extraperitoneal route, which prevent the risk of sepsis.