bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deaf Victims’ Experiences With Intimate Partner Violence: The Need for Integration and Innovation
Authors: Mastrocinque Jeanna M. , Thew Denise , Cerulli Catherine , Raimondi Christina , Pollard Robert Q , Chin Nancy P. 
Published: September 2015

While in recent years, intimate partner violence (IPV) has attracted considerable research attention, the experiences of IPV affecting the Deaf community have been understudied. As a linguistic and cultural minority, Deaf victims of IPV encounter significant barriers in accessing information and services designed to address the medical and legal consequences of victimization. The number of Deaf Americans who communicate via American Sign Language (ASL) may well exceed a half-million, yet little is known about Deaf IPV victims’ experiences and the characteristics of persons who perpetrate IPV with ASL users. This study addressed both topics. The current study is based on interviews in ASL with 14 Deaf IPV victims (participants). We explored: the types of abuse participants experienced; characteristics of victims and perpetrators; participants’ help-seeking behaviors; and the availability, use, and helpfulness of various resources. These findings were compared to what is known about IPV in the hearing community. Our findings include that lack of information regarding IPV and lack of access to specialized IPV services were pervasive problems affecting Deaf victims. For some victims, the close-knit nature of the Deaf community was a barrier for discussing IPV and accessing information and support. It was common for Deaf victims to receive services or information about IPV from providers who were not IPV specialists. Communication abuse was prevalent in our study. The nature of communication abuse is unique for Deaf victims compared to hearing victims.
Somatic musculature in trematode hermaphroditic generation
Authors: Krupenko Darya Y. , Dobrovolskij Andrej A. 
Published: September 2015

Abstract
Background
The somatic musculature in trematode hermaphroditic generation (cercariae, metacercariae and adult) is presumed to comprise uniform layers of circular, longitudinal and diagonal muscle fibers of the body wall, and internal dorsoventral muscle fibers. Meanwhile, specific data are few, and there has been no analysis taking the trunk axial differentiation and regionalization into account. Yet presence of the ventral sucker (= acetabulum) morphologically divides the digenean trunk into two regions: preacetabular and postacetabular. The functional differentiation of these two regions is already evident in the nervous system organization, and the goal of our research was to investigate the somatic musculature from the same point of view.

Results
Somatic musculature of ten trematode species was studied with use of fluorescent-labelled phalloidin and confocal microscopy. The body wall of examined species included three main muscle layers (of circular, longitudinal and diagonal fibers), and most of the species had them distinctly better developed in the preacetabuler region. In majority of the species several (up to seven) additional groups of muscle fibers were found within the body wall. Among them the anterioradial, posterioradial, anteriolateral muscle fibers, and U-shaped muscle sets were most abundant. These groups were located on the ventral surface, and associated with the ventral sucker. The additional internal musculature was quite diverse as well, and included up to twelve separate groups of muscle fibers or bundles in one species. The most dense additional bundles were found in the preacetabular region and were connected with the suckers.

Conclusions
Previously unknown additional somatic musculature probably provides the diverse movements of the preacetabular region, ventral sucker, and oral sucker (or anterior organ). Several additional muscle groups of the body wall (anterioradial, posterioradial, anteriolateral fibers and U-shaped sets) are proposed to be included into the musculature ground pattern of trematode hermaphroditic generation. This pattern is thought to be determined by the primary trunk morphofunctional differentiation into the preacetabular and the postacetabular regions.
Medicinal plants used to treat the most frequent diseases encountered in Ambalabe rural community, Eastern Madagascar
Authors: Rakotoarivelo Nivo H. , Rakotoarivony Fortunat , Ramarosandratana Aro Vonjy , Jeannoda Vololoniaina H. , Kuhlman Alyse R. , Randrianasolo Armand , Bussmann Rainer W. 
Published: September 2015

Abstract
Background
Traditional medicine remains the only health care available in many rural areas in Madagascar like the rural community of Ambalabe, located in a very remote area in the eastern part of the country. With limited access to modern medicine, the local population uses medicinal plants to treat most diseases. In this study, we aimed to inventory medicinal plants used by local people and how those relate to the treatment of the most frequent diseases encountered in Ambalabe.

Methods
We interviewed participants in order to identify the most frequent diseases in the region and the medicinal plants used to treat them. The local physician was asked about the most frequent diseases, and ethnobotanical surveys to record medicinal plants and their uses, using semi-structured interviews and free listing, were conducted among 193 informants in local villages, of which 54 % were men and 46 % were women, ageing from 16 to 86 years. The local names, the uses of each plant species and the way they are prepared and administered were recorded and accompanied by herbarium specimens for identification. We also interviewed four traditional healers to elicit more details on the preparation and the use of plants.

Results
Our research allowed us to identify six most frequent diseases, namely diarrhea, malaria, stomach-ache, cough, bilharzia and dysentery. Among 209 plant species identified as having medicinal use, 83 species belonging to 49 families and 77 genera were used to treat these diseases. Our analyses highlighted the 11 commonly used species for their treatment, and also 16 species with a high fidelity level (FL ≥ 75 %) for each ailment. Diarrhea is one of the diseases with high number of species recorded.

Conclusions
This study highlighted the closed relationship between people in Ambalabe and plant species, especially when faced with frequent diseases. However, most of the species used were collected in the surroundings of the villages. Few species were from Vohibe forest in which a management system on the use of plant species was already established. Therefore, a sustainable use management should be considered for wild species from which medicinal plants are highly abundant.
Integrated approach to the understanding of the degradation of an urban river: local perceptions, environmental parameters and geoprocessing
Authors: Collier Carolina A. , Almeida Neto Miguel S. de , Aretakis Gabriela MA , Santos Rangel E. , de Oliveira Tiago H. , Mourão José S. , Severi William , El-Deir Ana CA 
Published: September 2015

Abstract
Background
The use of interdisciplinary approaches such as the proposed report provides a broad understanding of the relationship between people and the environment, revealing reliable aspects not previously considered in the study of this relationship. This study compiled evidence on the environmental degradation of an urbanized river over the past few decades, providing a diagnosis of the consequences of this process for the river, its ichthyofauna, and the local human population.

Methods
The study was focused on the Beira Rio community on the Capibaribe River in the municipality of São Lourenço da Mata, Pernambuco, Brazil. Data were collected using geoprocessing and ethnobiological approaches, as well as environmental parameters. This research was conducted with the most experienced long-term residents in the local community, through interviews and participatory methodologies to recovering information about the river environment, its ichthyofauna and its environmental services for the last decades.

Results
According to the GIS analysis, the study area was subject to an accelerated process of urbanization, with the total urban area increasing from 73 565, 98 m2 in 1974 to 383 363, 6 m2 in 2005. The informants perceived the urban growth, especially in the late twentieth century, being this period recognized as the phase of greatest negative changes in the river environment. The perceived decline of fish stocks was indicated by the community as one of the effects of river degradation. According to the interviews, the deterioration of the river affected the ecosystem services and the relationship of the adjacent human community with this ecosystem. The environmental data indicated that the river is suffering eutrophization and has fecal coliform concentrations 160 times higher than the maximum level permitted by Brazilian legislation.

Conclusions
The interdisciplinary approach used in this research allowed the understanding of the degradation process of an urban river and some negative effects through the integration of environmental data, GIS and the local knowledge, revealing the complementarity of obtained data and the effectiveness of implementation of this approach.
Brain metabolism and cerebrospinal fluid biomarkers profile of non-amnestic mild cognitive impairment in comparison to amnestic mild cognitive impairment and normal older subjects
Authors: Coutinho Artur M N , Porto Fábio H G , Duran Fabio L S , Prando Silvana , Ono Carla R , Feitosa Esther A A F , Spíndola Lívia , de Oliveira Maira O. , do Vale Patrícia H F , Gomes Helio R. , Nitrini Ricardo , Brucki Sonia M D , Buchpiguel Carlos A. 
Published: September 2015

Abstract
Introduction
Mild cognitive impairment (MCI) is classically considered a transitional stage between normal aging and dementia. Non-amnestic MCI (naMCI) patients, however, typically demonstrate cognitive deficits other than memory decline. Furthermore, as a group, naMCI have a lower rate of an eventual dementia diagnosis as compared to amnestic subtypes of MCI (aMCI). Unfortunately, studies investigating biomarker profiles of naMCI are scarce. The study objective was to investigate the regional brain glucose metabolism (rBGM) with [18F]FDG-PET and cerebrospinal fluid (CSF) biomarkers in subjects with naMCI as compared to a control group (CG) and aMCI subjects.

Methods
Ninety-five patients were included in three different groups: naMCI (N = 32), aMCI (N = 33) and CG (N = 30). Patients underwent brain MRI and [18F]FDG-PET. A subsample (naMCI = 26, aMCI = 28) also had an assessment of amyloid-β, tau, and phosphorylated tau levels in the CSF.

Results
Both MCI groups had lower rBGM in relation to the CG in the precuneus. Subjects with naMCI showed decreased right prefrontal metabolism as well as higher levels of CSF amyloid-β relative to aMCI subjects.

Conclusion
While amnestic MCI subjects showed a biomarker profile classically related to MCI due to Alzheimer’s disease, naMCI patients illustrated a decrease in both prefrontal hypometabolism and higher CSF amyloid-β levels relative to the aMCI group. These biomarker findings indicate that naMCI is probably a heterogeneous group with similar precuneus hypometabolism compared to aMCI, but additional frontal hypometabolism and less amyloid-β deposition in the brain. Clinical follow-up and reappraisal of biomarkers of the naMCI group is needed to determine the outcome and probable etiological diagnosis.
Cyclic admissible contraction and applications to functional equations in dynamic programming
Authors: Isik Huseyin , Samet Bessem , Vetro Calogero 
Published: September 2015

AbstractIn this paper, we introduce the notion of T-cyclic $( \alpha ,\beta ) $
(
α
,
β
)
-contraction and give some common fixed point results for this type of contractions. The presented theorems extend, generalize, and improve many existing results in the literature. Several examples and applications to functional equations arising in dynamic programming are also given in order to illustrate the effectiveness of the obtained results.
Indeterminacy in process type classification
Authors: Gwilliams Laura , Fontaine Lise 
Published: September 2015

AbstractClausal analysis within Systemic Functional Linguistics (SFL) is generally based upon a classification of the clause into one of six process types. Although this allocation is often portrayed as clear-cut, in practice process distinction can be unclear, and a single verb may meet the coding criteria of a number of categories. The aim of this paper is to examine the nature of indeterminacy within a transitive SFL analysis, by surveying experienced SFL users for their classification of 20 clauses. Our main findings are threefold: 1) inconsistency of analysis was very prevalent - we find only one of the critical clauses to be unanimously categorised for process type; 2) the main area of disagreement between analysts was the selection of Material vs. Verbal processes; 3) clauses with low consistency ratings appeared to include performative main verbs. These findings are discussed in the light of the semantic properties of performativity, which may contribute to the difficulty in process type identification; further, possible alleviations to these issues are discussed in order to allow for a full consideration of both the syntactic and semantic realisation of the clause, in situations where these streams of information may diverge.
Lobular Carcinoma in Situ: A 29-Year Longitudinal Experience Evaluating Clinicopathologic Features and Breast Cancer Risk
Authors: King Tari A. , Pilewskie Melissa , Muhsen Shirin , Patil Sujata , Mautner Starr K. , Park Anna , Oskar Sabine , Guerini-Rocco Elena , Boafo Camilla , Gooch Jessica C. , De Brot Marina , Reis-Filho Jorge S. , Morrogh Mary , Andrade Victor P. , Sakr Rita A. , Morrow Monica 
Published: September 2015

Purpose The increased breast cancer risk conferred by a diagnosis of lobular carcinoma in situ (LCIS) is poorly understood. Here, we review our 29-year longitudinal experience with LCIS to evaluate factors associated with breast cancer risk. Patients and Methods Patients participating in surveillance after an LCIS diagnosis are observed in a prospectively maintained database. Comparisons were made among women choosing surveillance, with or without chemoprevention, and those undergoing bilateral prophylactic mastectomies between 1980 and 2009. Results One thousand sixty patients with LCIS without concurrent breast cancer were identified. Median age at LCIS diagnosis was 50 years (range, 27 to 83 years). Fifty-six patients (5%) underwent bilateral prophylactic mastectomy; 1,004 chose surveillance with (n = 173) or without (n = 831) chemoprevention. At a median follow-up of 81 months (range, 6 to 368 months), 150 patients developed 168 breast cancers (63% ipsilateral, 25% contralateral, 12% bilateral), with no dominant histology (ductal carcinoma in situ, 35%; infiltrating ductal carcinoma, 29%; infiltrating lobular carcinoma, 27%; other, 9%). Breast cancer incidence was significantly reduced in women taking chemoprevention (10-year cumulative risk: 7% with chemoprevention; 21% with no chemoprevention; P < .001). In multivariable analysis, chemoprevention was the only clinical factor associated with breast cancer risk (hazard ratio, 0.27; 95% CI, 0.15 to 0.50). In a subgroup nested case-control analysis, volume of disease, which was defined as the ratio of slides with LCIS to total number of slides reviewed, was also associated with breast cancer development (P = .008). Conclusion We observed a 2% annual incidence of breast cancer among women with LCIS. Common clinical factors used for risk prediction, including age and family history, were not associated with breast cancer risk. The lower breast cancer incidence in women opting for chemoprevention highlights the potential for risk reduction in this population.
Comparison of the Genomic Landscape Between Primary Breast Cancer in African American Versus White Women and the Association of Racial Differences With Tumor Recurrence
Authors: Keenan Tanya , Moy Beverly , Mroz Edmund A. , Ross Kenneth , Niemierko Andrzej , Rocco James W. , Isakoff Steven , Ellisen Leif W. , Bardia Aditya 
Published: September 2015

Purpose African American women are more likely to die as a result of breast cancer than white women. The influence of somatic genomic profiles on this racial disparity is unclear. We aimed to compare the racial distribution of tumor genomic characteristics and breast cancer recurrence. Methods We assessed white and African American women with stage I to III breast cancer diagnosed from 1988 to 2013 and primary tumors submitted to The Cancer Genome Atlas from 2010 to 2014. We used Cox proportional hazards models to evaluate the association of race and genetic traits with tumor recurrence. Results We investigated exome sequencing and gene expression data in 663 and 711 white and 105 and 159 African American women, respectively. African Americans had more TP53 mutations (42.9% v 27.6%; P = .003) and fewer PIK3CA mutations (20.0% v 33.9%; P = .008). Intratumor genetic heterogeneity was greater in African American than white tumors overall by 5.1 units (95% CI, 2.4 to 7.7) and within triple-negative tumors by 4.1 units (95% CI, 1.4 to 6.8). African Americans had more basal tumors by the 50-gene set predictor using the predication analysis of microarray method (PAM50; 39.0% v 18.6%; P < .001) and fewer PAM50 luminal A tumors (17.0% v 34.7%; P < .001). Among triple-negative subtypes, African Americans had more basal-like 1 and mesenchymal stem-like tumors. African Americans had a higher risk of tumor recurrence than whites (hazard ratio, 2.22; 95% CI, 1.05 to 4.67). Racial differences in TP53 mutation, PAM50 basal subtype, and triple-negative tumor prevalence but not intratumor genetic heterogeneity influenced the magnitude and significance of the racial disparity in tumor recurrence. Conclusion African Americans had greater intratumor genetic heterogeneity and more basal gene expression tumors, even within triple-negative breast cancer. This pattern suggests more aggressive tumor biology in African Americans than whites, which could contribute to racial disparity in breast cancer outcome.
Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial
Authors: Demetri George D. , von Mehren Margaret , Jones Robin L. , Hensley Martee L. , Schuetze Scott M. , Staddon Arthur , Milhem Mohammed , Elias Anthony , Ganjoo Kristen , Tawbi Hussein , Van Tine Brian A. , Spira Alexander , Dean Andrew , Khokhar Nushmia Z. , Park Youn Choi , Knoblauch Roland E. , Parekh Trilok V. , Maki Robert G. , Patel Shreyaskumar R. 
Published: September 2015

Purpose This multicenter study, to our knowledge, is the first phase III trial to compare trabectedin versus dacarbazine in patients with advanced liposarcoma or leiomyosarcoma after prior therapy with an anthracycline and at least one additional systemic regimen. Patients and Methods Patients were randomly assigned in a 2:1 ratio to receive trabectedin or dacarbazine intravenously every 3 weeks. The primary end point was overall survival (OS), secondary end points were disease control—progression-free survival (PFS), time to progression, objective response rate, and duration of response—as well as safety and patient-reported symptom scoring. Results A total of 518 patients were enrolled and randomly assigned to either trabectedin (n = 345) or dacarbazine (n = 173). In the final analysis of PFS, trabectedin administration resulted in a 45% reduction in the risk of disease progression or death compared with dacarbazine (median PFS for trabectedin v dacarbazine, 4.2 v 1.5 months; hazard ratio, 0.55; P < .001); benefits were observed across all preplanned subgroup analyses. The interim analysis of OS (64% censored) demonstrated a 13% reduction in risk of death in the trabectedin arm compared with dacarbazine (median OS for trabectedin v dacarbazine, 12.4 v 12.9 months; hazard ratio, 0.87; P = .37). The safety profiles were consistent with the well-characterized toxicities of both agents, and the most common grade 3 to 4 adverse effects were myelosuppression and transient elevation of transaminases in the trabectedin arm. Conclusion Trabectedin demonstrates superior disease control versus conventional dacarbazine in patients who have advanced liposarcoma and leiomyosarcoma after they experience failure of prior chemotherapy. Because disease control in advanced sarcomas is a clinically relevant end point, this study supports the activity of trabectedin for patients with these malignancies.
An update of novel identified cytogenetic and molecular biomarkers in the laboratory diagnosis of hematological neoplasia
Authors: Hinrichsen Tanja , Kuehner Stefanie , Subklewe Marion 
Published: September 2015

Abstract
Cancer diagnosis and identification of novel biomarkers are a rapidly changing field and open new doors into personalized medicine. Particularly in the diagnosis of hematological neoplasia, the identification of novel biomarkers has become more important because of biological sub-classification, prognosis and targeted and individualized therapies. Therefore, techniques like blood count, morphology, cytochemistry, histology, immunophenotyping, cytogenetics and molecular genetics are essential and cannot be denied nowadays. In the last years, a broad spectrum of novel molecular biomarkers has been identified in the genetic and molecular characterization of myelodysplastic syndromes. Lots of these novel molecular biomarkers gained entry in the routine diagnostics and provide an excess profit for patients. However, to ensure a cost-effective, targeted and individualized diagnostic testing, application of existing techniques has to be weighed against each other to obtain the best possible combination of targeted diagnostics. This review summarized thus far the diagnostic-relevant morphologic, cytogenetic and molecular biomarkers in the laboratory diagnosis of hematological neoplasia.
Crystal structure of 4-chloro-3'-methoxy-[1,1'-biphenyl]-3-carbaldehyde, C14H11ClO2
Authors: Cao Weiwei , Gan Haifeng , Chen Zhengbang , Guo Kai 
Published: September 2015

Abstract C14H11ClO2, orthorhombic, P212121 (no. 19), a = 4.1210(8) Å, b = 11.363(2) Å, c = 24.982(5) Å, V = 1169.8 Å3, Z = 4, Rgt(F) = 0.0572, wRref(F2) = 0.1287, T = 293 K.
Crystal structure of 5-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methylene)- thiazolidine-2,4-dione, C12H9NO4S
Authors: Liu Yong-De , Yan Lu-Bing , Wang Xin-Yi , Sun Juan 
Published: September 2015

Abstract C12H9NO4S, triclinic, P1̅ (no. 2), a = 3.9201(5) Å, b = 11.836(2) Å, c = 13.105(2) Å, ɑ = 67.415(4)°, β = 83.375(4)°, γ = 82.156(4)°, V = 554.8 Å3, Z = 2, Rgt(F) = 0.0401, wRref(F2) = 0.0999, T = 293 K.
Crystal structure of bis(2-trifluoromethyl-4-nitrophenyl) terephthalate — acetic acid (1:1), C24H14F6N2O10
Authors: Chen Wei , Ji Mian , Yang Shiyong 
Published: September 2015

Abstract C24H14F6N2O10, triclinic, P1̅ (no. 2), a = 9.985(2) Å, b = 11.496(3) Å, c = 12.721(2) Å, ɑ = 107.297(9)°, β = 112.982(9)°, γ = 94.214(14)°, V = 1253.4 Å3, Z = 2, Rgt(F) = 0.0656, wRref(F2) = 0.1427, T = 173 K.
Data cleaning in the process industries
Authors: Xu Shu , Lu Bo , Baldea Michael , Edgar Thomas F. , Wojsznis Willy , Blevins Terrence , Nixon Mark 
Published: September 2015

AbstractIn the past decades, process engineers are facing increasingly more data analytics challenges and having difficulties obtaining valuable information from a wealth of process variable data trends. The raw data of different formats stored in databases are not useful until they are cleaned and transformed. Generally, data cleaning consists of four steps: missing data imputation, outlier detection, noise removal, and time alignment and delay estimation. This paper discusses available data cleaning methods that can be used in data pre-processing and help overcome challenges of “Big Data”.