bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychological Disturbances in Indian Children with Atopic Eczema
Authors: Sarkar Rashmi , Raj Lok , Kaur Harprit , Basu Srikanta , Kanwar Amrinder Jit , Jain Rakesh Kumar 
Published: July 2014

AbstractAlthough the link between atopic dermatitis (AD) and emotional disturbance is well known, there have been only a few studies assessing the extent of these disturbances in affected children and the problems experienced by their parents. Furthermore, these studies are mostly from western countries, where atopic dermatitis is seen in a more severe form than in India. The purpose of this study was to determine whether there is an excess of psychological disorders in Indian children with AD as compared to healthy controls and whether their mothers showed higher levels of emotional or mental distress than a comparison group. Twenty‐two children, aged 3–9 years, with atopic dermatitis, twenty age and sex matched controls, and their mothers were selected for the study. The personalities of the mothers were assessed from a standard and valid questionnaire, the Hindi adaptation of Personality Trait Inventory, which explored nine areas of the maternal personality and mental distress as well as negative traits of some of these. The two groups were compared using the Chi‐square test. To assess the psychopathology of the children, the mothers were made to answer parts of a valid, well‐developed questionnaire, the Childhood Psychopathology Measurement Schedule, which enabled the assessment of the following factors: low intelligence with behaviour disorders, conduct disorders, anxiety, and depression. The means of each factor in both the groups were compared using the Students' t‐test. Out of all the maternal personality traits, an increased number of mothers of affected children, 13 (59%) were found to be submissive as compared to the mothers of the controls i.e. 2 (10%), which was statistically significant (p<0.01). The children with AD had a higher frequency of low intelligence with behaviour disorders (5.9 ± 2.9) as compared to controls and also of conduct disorders (2.1 ± 1.4), which were both statistically significant (p<0.01). The results of this pilot study, although small in number, suggest that increased psychological disorders are observed in Indian children with AD as compared to controls, despite the fact that the disease is of a milder variety in this country as compared to its western counterparts. More mothers of children with AD were submissive, which could contribute to the psychological disorders and maintenance of eczema in the children. We suggest that children with AD may benefit if such psychological dimensions are considered as a part of their treatment.
Neutrophilic Dermatosis of the Dorsal Hand
Authors: Bilu Donna , Kouba David J. , Mamelak Adam J. , Kazin Rebecca A. , Nousari Carlos H. 
Published: July 2014

AbstractNeutrophilic dermatosis of the dorsal hands (NDDH) was originally described as pustular vasculitis (PV) of the hands. Recent debate focuses on categorizing this disorder in the family of neutrophilic dermatoses (ND), as opposed to a primary vasculitis. We present a case of NDDH with clinical and histologic features consistent with ND, and discuss the major concerns for this disease's reclassification.
Punctate Palmoplantar Keratoderma with Pigmentary Lesions on the Dorsa of Feet and Ankles: Successful Treatment with a Combination of Low‐Dose Oral Etretinate and Topical Calcipotriol
Authors: Horikoshi Mariko , Kuroda Kei , Tajima Shingo 
Published: July 2014

AbstractWe describe a patient with typical keratotic lesions of punctate palmoplantar keratoderma on the hands and feet and unique pigmentary lesions on the dorsa of the feet and ankles. A combination of low‐dose oral etretinate (10 mg/day) and calcipotriol ointment 0.005% resulted in a complete regression, whereas pigmentary lesions on the dorsa of the feet and ankles did not change during the treatment.
Topical Imiquimod 5% Cream in External Anogenital Warts: A Randomized, Double‐Blind, Placebo‐Controlled Study
Authors: Arican Ozer , Guneri Funda , Bilgic Kaan , Karaoglu Aynur 
Published: July 2014

AbstractThe complete treatment of anogenital warts has not been obtained with any combination of methods; therefore, new methods are still under investigation. In this study the activity and side effects of imiquimod 5% cream were investigated. The study group consisted of 23 male and 11 female volunteers and the control group of 9 male and 2 female volunteers. Patients applied the cream three times a week, every other day in the evenings for a period of 12 weeks. After the treatment, patients were regularly monitored for six months for recurrences. At the end of the study, 23 (69.7%) patients (all of females and 54.5% of males) in the study group displayed a complete clearance, 9 patients displayed 50–90% clearance and 1 patient displayed less than 50% clearance. In the control group, only 1 patient displayed a complete clearance, 1 patient displayed 50–90% clearance, and the other 8 patients showed no alteration in the lesions. These results were statistically significantly different (p<0.01). In 15 patients in the study group, no side effects were reported; the most frequently seen side effects were erythema and erosion. In six patients that were observed for a period of six months, recurrences occurred. Imiquimod 5% cream is a topically applied medicament that should be considered as an effective and reliable medical option in the treatment of anogenital warts.
Lack of Response to Isotretinoin in Annular Elastolytic Giant Cell Granuloma
Authors: Basak Pinar Y. , Icke Ilkay , Akkaya Vahide B. , Basak Kayhan 
Published: July 2014

AbstractAnnular elastolytic giant cell granuloma is a rare disease characterized by annular configurated lesions with typical histopathologic findings. We report a case of annular elastolytic giant cell granuloma in a 50‐year‐old male patient. Treatment modalities for this disease are limited and mostly unsatisfactory, although isotretinoin was found to be effective in a single case. However, systemic isotretinoin treatment of 12 weeks' duration was of no benefit in the presented case.
Eosinophilic Pustular Folliculitis (Ofuji's Disease) in a Patient with Silicone Tissue Augmentation
Authors: Wong Tak‐Wah , Tsai Ya‐Ming , Lee J. Yu‐Yun , Hsu Shih‐Tsung , Sheu Hamm‐Ming 
Published: July 2014

AbstractEosinophilic pustular folliculitis (EPF) (Ofuji's disease) is a rare dermatosis of unknown etiology. We describe a 45‐year‐old Chinese woman who developed EPF on her face seven years after having nose and chin augmentation with subcutaneous silicone injections.
Acquired Reactive Perforating Collagenosis in a Patient with Lung Fibrosis
Authors: Tsuboi Hiromi , Mukuno Akira , Sato Naoya , Katsuoka Kensei , Yanase Nobuo 
Published: July 2014

AbstractReactive perforating collagenosis (RPC) is a rare disorder characterized by the transepidermal elimination of altered collagen. The inherited form of RPC begins in early childhood, but acquired reactive perforating collagenosis (ARPC) begins in adult life. ARPC is associated with diabetes mellitus, renal disease, and malignancy. ARPC with lung fibrosis has not previously been reported in the literature, and the relationship between ARPC and lung fibrosis has not been studied. The etiological relationship between the two disorders appears to be uncertain. Although their association in this case could be due to chance, it may be due to the transforming growth factor β abnormalities seen in both diseases. In this report, we describe a case of ARPC with lung fibrosis and propose an etiological association between the two diseases.
Asymmetrical Nonscalp Aplasia Cutis Congenita: A Case Report
Authors: Atik Bekir , Tan Onder , Bayram Irfan , Tuncer Oguz , Kirimi Ercan 
Published: July 2014

AbstractAplasia cutis congenita or congenital absence of the skin is a rare and serious congenital disease; its etiopathogenesis remains unclear. In this condition, localized or widespread areas of skin are absent at birth. A newborn suffering from an unusual aplasia cutis congenita located asymmetrically on the nonscalp, without blistering, was presented. This patient was completely healed with conservative treatment.
Malassezia Folliculitis on the Scalp of a 12‐Year‐Old Healthy Child
Authors: Aytimur Derya , Sengöz Vildan 
Published: July 2014

AbstractMalassezia folliculitis is a condition chracterized by itchy follicular papules and pustules with erythema. Malassezia yeasts are the pathogens in this condition. It is mainly located on the back, shoulders, and chest. Presented here is a 12‐year‐old boy with malassezia folliculitis on the scalp. The case was found to be worthy of presentation because it rarely occurs in childhood and is rarely located on the scalp.
Subcutaneous Solitary Fibrous Tumor
Authors: Yoshida Yuichi , Kubota Yumiko , Yamaguchi Takahiro , Iwasaki Hiroshi , Nakayama Juichiro 
Published: July 2014

AbstractWe describe a unique case of subcutaneous solitary fibrous tumor (SFT) in a 56‐year‐old female patient. The patient had been aware of a painless soft mass in her back for ten years. The lesion was surgically excised. Histological examination revealed that the well‐defined mass was composed of a proliferation of spindle‐shaped fibroblastic cells and polygonal cells embedded in a fibrous matrix corresponding to the so‐called “patternless pattern”. A prominent pericytomatous pattern (hemangiopericytoma‐like structures), focal myxoid changes, and thick hyalinized collagen fibers were also observed. Immunohistochemical stainings for CD34 and bcl‐2 were positive in the tumor cells. These features are compatible with SFT. We suggest that SFT should be included in the differential diagnosis of subcutaneous spindle cell tumors.
Langerhans Cell Histiocytosis Involving the Skin of an Elderly Woman: A Satisfactory Remission with Oral Prednisolone Alone
Authors: Imanaka Aiko , Tarutani Masahito , Itoh Haruyasu , Kira Masahiro , Itami Satoshi 
Published: July 2014

AbstractLangerhans cell histiocytosis (LCH) is a disorder characterized by neoplastic proliferation of Langerhans cells that rarely involves the skin in adults. A 74‐year‐old woman presented with a fourteen year history of eosinophilic granuloma and bone involvement caused by LCH. She had received three combination therapy courses of curettage and radiation since 1987 and had remained free of LCH signs for seven years, after which she started to notice brown nodules on her left leg. Biopsy specimens taken from the lesions showed massive proliferations of large histiocytic cells. Immunoperoxidase stainings for CD1a and S‐100 protein were positive. Electron microscopy identified Birbeck granules in the cytoplasm of the atypical Langerhans cells. Treatment with oral prednisolone alone has resulted in the patient remaining in complete remission for 12 months.
Histologic Progression of B16 F10 Metastatic Melanoma in C57BL/6 Mice Over a Six Week Time Period: Distant Metastases before Local Growth
Authors: Eberting Cheryl Lee D. , Shrayer David P. , Butmarc Janet , Falanga Vincent 
Published: July 2014

AbstractB16F10 murine metastatic melanoma in the tails of C57BL/6 mice after subcutaneous injection is a well‐established model. However, the histologic progression from injected cells to established local growth of melanoma has not been studied systematically. We therefore have investigated the histologic changes and growth of B16F10 melanoma at the injection site over a six‐week time period. One million B16F10 melanoma cells were injected subcutaneously into the dorsal aspect of tails of C57/BL6 mice. Mice were sacrificed at zero, 12, 24, 48, 72 and 96 hours, and at one, two, three, four, five and six weeks. Sections were stained with Hematoxylin and Eosin and immunostained with antibodies to S100. Beginning at time zero, melanoma cells were detected between the dermis and the myofascial bundle of the tail. At week four, distant metastases were clinically evident in the inguinal region, though injection site tumors did not become evident until week six. Histological analysis showed melanoma cells at the injecion site at all time periods and no injection site tumor until week six. Indeed, the injection site tumors arose two weeks after distant metastases were clinically apparent. A progression of S100 positivity was also observed. S100 immunostaining was negative in all injection site of B16F10 cells until the cells underwent a morphologic change from small and monomorphic at the injection site, to large, pleomorphic cells at week six in the clinically evident injection site tumors. Inguinal metastases were also S100 positive at week four, though injection site cells were still S100 negative. We conclude that in this particular established model for melanoma, local growth at the injection site may occur after the development of regional metastases. This may prove to be a good model for investigation of local growth of tumor cells and their interaction with metastatic lesions.
Successful Treatment of Pulmonary Metastasis and Local Recurrence of Angiosarcoma with Docetaxel
Authors: Isogai Rieko , Kawada Akira , Aragane Yoshinori , Tezuka Tadashi 
Published: July 2014

AbstractAngiosarcoma of the face and scalp of the elderly frequently recurs locally, metastasizes early despite various treatments, and has a poor prognosis. We describe a patient who had angiosarcoma of the scalp with pulmonary metastasis. Local recurrence occurred after excision and local and arterial administration of IL‐2. A weekly administration method of docetaxel was therefore selected, resulting in complete remission of the pulmonary metastasis and a partial response of the local recurrence. This favorable clinical outcome in our case suggests that docetaxel therapy may be an option for the treatment of angiosarcoma of the scalp with pulmonary metastasis.
Unilateral Nevoid Telangiectasia and Hyperthyroidism: A New Association or Coincidence?
Authors: Kavak Ayse , Kutluay Lale 
Published: July 2014

AbstractTelangiectasia and spider angioma were distributed in a unilateral, dermatomal pattern in a female patient. Physical examination and laboratory studies revealed hyperthyroidism. The possible effects of thyroid hormones on formation of vascular nevi were considered to be noteworthy.
Pruritic Papular Eruption Associated with HIV‐Etiopathogenesis Evaluated by Clinical, Immunohistochemical, and Ultrastructural Analysis
Authors: Ramos Heloisa , Pagliari Carla , Takakura Cleusa Fumica Hirata , Sotto Mirian Nacagami , Duarte Maria Irma Seixas 
Published: July 2014

AbstractPruritic Papular Eruption with Human Immunodeficiency Virus infection (PPE‐HIV) is characterized by symmetrically distributed papules with pruritus in the skin of patients suffering advanced HIV infection. Although known since 1985, the etiology of this symptomatic dermatitis is unclear. We set out to characterize the phenotype of the infiltrating cells and the cytokine profile in the lesions, as an attempt to contribute to determining its etiopathogenesis. Clinical data and histological, immunohistochemical, and ultrastructural features of skin biopsies from 20 HIV patients with PPE were studied. The histopathological aspects, cell immunophenotypes, and cytokine expressions in the lesions where quantified and compared to perilesional skin, and to those in the clinically normal skin of HIV patients without PPE‐HIV (n=11) and those in normal skin samples from HIV negative individuals (n=10). PPE‐HIV occurred mainly in HIV patients with mean CD4+ counts of 124.6 ± 104 lymphocytes/mm3. Furthermore, their eosinophil counts were significantly increased. The skin lesions were characterized by a predominantly perivascular dermal lymphohistiocytic inflammatory infiltrate. Langerhans cells were normally distributed in the epidermis and seen among the cellular components of dermal infiltrates. The density of CD8+ lymphocytes was elevated and the density of CD4+ cells was reduced in dermal infiltrates. Interleukin 5 was the predominant cytokine in the lesions. Electron microscopic analysis didn't disclose HIV or other infectious agents in the lesions. These results refute the hypothesis of an infectious etiology of PPE‐HIV. CD8+ lymphocytes and Langerhans cells seem to have roles in the pathogenesis of PPE‐HIV. The increased frequency of IL5 was associated with abundant eosinophils in the lesions, suggesting a type Th2 response in this dermatitis.
Sporotrichosis in a Husband and Wife
Authors: Umemoto Naoka , Demitsu Toshio , Osawa Masumi , Toda Sunao , Kawasaki Masako , Mochizuki Takashi 
Published: July 2014

AbstractFamilial occurrence of sporotrichosis is rare. We report two patients, a husband and wife, with sporotrichosis. A 67‐year‐old man and a 63‐year‐old woman, who were farmers, had erythematous plaques and nodules on their faces and his forearm. They had noticed their cutaneous lesions during nearly the same period without any traumatic history. Fragments of biopsy specimens from both of them were submitted for mycological cultures and yielded pure cultures of Sporothrix schenckii (S. schenckii). Restriction fragment length polymorphisms in the mitochondrial DNA of the S. schenckii isolated from the biopsy specimens of their lesions were investigated. The isolates were identified as type 5, which is comparatively abundant in the Kanto area in Japan. The husband was treated with potassium iodide and itraconazole. His wife was treated with itraconazole alone. We failed to isolate a causative fungus from the soil. Our case is the second case in the literature of sporotrichosis in a husband and wife during the same period.
Localization of 125I‐labelled α‐r‐atrial natriuretic peptide in rat tissues by whole‐body and microautoradiography
Authors: TJÄLVE H. , WILANDER E. 
Published: July 2014

125I‐labelled α rat atrial natriuretic peptide (28 amino acids: Ser 99–Tyr 126) ([125I]α‐rANP) was given i.v. to Sprague—Dawley rats and the distribution of radioactivity in the tissues was examined by whole‐body and microautoradiography at intervals from 2 min to 4 h after the administration. Inhibition of uptake of the [125I]α‐rANP by simultaneous injection of an excess of non‐labelled α‐rANP was taken as an indication that highly labelled structures in rats injected with [125I]α‐rANP alone are due to an abundance of specific receptors for the peptide. In the rats given only the [125I]α‐rANP a rapid and high radioactivity occurred in the renal glomeruli, the endocardium of the heart ventricles, the endothelium of the processus ciliares of the eyes, the portal vessels and a few larger vessels of the liver, the subcapsular vessels of the adrenal glands and the parenchyma of the lungs. Other tissues showing a distinct, but less prominent, radioactivity were the endocardium of the heart atria, the walls of the great afferent and efferent vessels in the thoracic cavity, the choroid plexuses of the brain ventricles, the pia mater, brown fat, the muscularis layer of the stomach and the intestines, the lamina propria of the villi in the small intestine and the walls of a few small blood vessels in the kidney medulla. The specific labelling was highest at 2 min after injection and then diminished at later intervals.Several of the labelled structures are localized in tissues involved in the regulation of blood pressure, and fluid and electrolyte homeostasis, processes in which the atrial peptides are considered to play a role. It is suggested that high concentrations of receptors are present at the sites at which the [125I]α‐rANP was strongly localized and that biological effects of the atrial peptides are exerted via these structures.
Renal sympathetic nerve activity during morphine abstinence in sino‐aortic baroreceptor‐denervated rats
Authors: DELLE M. , RICKSTEN S.‐E. , THORÉN P. 
Published: July 2014

This study was undertaken to investigate the influence of the arterial baroreceptors on the response of renal sympathetic nerve activity (rSNA) during naloxone‐precipitated morphine abstinence in rats. In chronically baroreceptor‐denervated, morphine‐dependent rats, rSNA, mean arterial pressure (MAP) and heart rate (HR) were studied before and after repeated i.v. bolus doses of naloxone (0.005–5 mg kg−1), during chloralose anaesthesia or in the conscious state.In the anaesthetized animals, naloxone doses of 0.05–5 mg kg−1 caused a pronounced inhibition of rSNA, reaching a level 61 % below pre‐naloxone activity. This was accompanied by increases in MAP and HR. In the conscious rats, the lower doses of naloxone elicited an initial state of increased somatomotor activity. This was paralleled by slight increases in rSNA and MAP. After 4–5 min, the behavioural excitation faded and was replaced by lethargy. The rats exhibited still signs of withdrawal in the form of piloerection, chromodacryorrhoea and defaecations. Concomitantly, rSNA returned towards the pre‐naloxone level, while MAP showed a sustained increase. The higher naloxone doses exacerbated the hypertension without any further changes in rSNA or in behaviour.We conclude that the influence of the baroreceptors is of minor significance for the inhibition of rSNA during naloxone‐precipitated abstinence in anaesthetized rats. In conscious, intact rats, however, the baroreceptors seem to contribute to rSNA inhibition since no significance decrease of rSNA occurred in baroreceptor‐denervated rats in the present study. This is in contrast to our previous finding of a marked inhibition of rSNA in rats with intact baroreceptors.
Challenges and Opportunities for Collecting and Sharing Data on Water Governance Institutions
Authors: Gallaher Samuel , Heikkila Tanya 
Published: July 2014

AbstractThis article explores the usability and availability of data needed for investigating the interplay between institutional arrangements (i.e. rules, regulations, policy, compacts, laws) and water resource outcomes. It examines a sample of 33 water governance and water research organizations’ websites for publicly available datasets containing linked information on institutions and water resource conditions or outcomes. While scholars and decision‐makers alike have identified institutional arrangements as an important aspect of improving water governance, their calls for enhancing publicly available institutional data remain unanswered. Within our sample of websites, few datasets link institutions and water resource conditions or outcomes and those that do limit the institutional data to jurisdictional boundaries. More in‐depth and diverse institutional data are required to understand which governance tools and structures do and do not work in varying contexts. This will require funding of strategically located, place‐based data collection efforts, more transparent and replicable data collection instruments, and coding and storage of institutional data for enhanced data integration.