bluuebunny/crossref_metadata_2025_split huggingface dataset:
An increasing incidence of type 1 diabetes mellitus in Romanian children aged 0 to 17 years
Authors: Serban Viorel , Brink Stuart , Timar Bogdan , Sima Alexandra , Vlad Mihaela , Timar Romulus , Vlad Adrian 
Published: January 2015

AbstractThe epidemiology of type 1 diabetes mellitus may provide insights into the pathogenesis of the disease.The aim of this work was to characterize the trend of the incidence of type 1 diabetes mellitus in Romanian children aged from 0 to 17 years over a 10-year interval.Data regarding new cases were obtained from two sources: (1) The Romanian Childhood Diabetes Registry and (2) Records of the Medical Center “Cristian Serban”, Buzias. The demographic data were retrieved from the National Institute for Statistics. The incidence was calculated for the age groups 0–4, 5–9, 10–14, and 15–17 years.A total of 3196 new cases, aged below 18 years, were found by both the sources. There were significant differences between the groups (p=0.012), the mean incidence being highest in the age group 10–14 years (9.6/100,000/year, 95% CI 9–10.1) and lowest in children aged from 0 to 4 years (4.8/100,000/year, 95% CI 4.4–5.3). Boys were slightly more frequently affected than girls (p=0.038). The age and gender adjusted incidence of type 1 diabetes mellitus increased significantly (p<0.001) from 6.2/100,000/year (95% CI 5.5–6.9) in 2002 to 9.3/100,000/year (95% CI 8.4–10.3) in 2011. The raise in incidence was noticed in all age groups except for 15–17 years.Romania is a country with an intermediate incidence of type 1 diabetes mellitus in children, which is slightly higher in boys than in girls. The incidence of type 1 diabetes mellitus increased continuously during the 10-year survey, with the exception of the oldest teens.
Testing genotypes-phenotype relationships using permutation tests on association rules
Authors: Shaikh Mateen , Beyene Joseph 
Published: January 2015

AbstractAssociation rule mining is a knowledge discovery technique which informs researchers about relationships between variables in data. These relationships can be focused to a specific set of response variables. We propose an augmented version of this method to discover groups of genotypes which relate to specific outcomes. We derive the methodology to find these candidate groups of genotypes and illustrate how the method works on data regarding neuroinvasive complications of West Nile virus and through simulation.
Relationship Between Pore Structure and Sorption-Induced Deformation in Hierarchical Silica-Based Monoliths
Authors: Balzer Christian , Morak Roland , Erko Maxim , Triantafillidis Christos , Hüsing Nicola , Reichenauer Gudrun , Paris Oskar 
Published: January 2015

Abstract
Experimental results on sorption-induced deformation during n-pentane
desorption were obtained by in-situ dilatometry and in-situ small
angle X-ray scattering (SAXS). The sample investigated was
a silica-based monolith with hierarchical pore structure comprising
a macroporous network of struts, each strut containing well-defined
cylindrical mesopores ordered on a 2D hexagonal lattice. In-situ
dilatometry and in-situ SAXS measurements revealed strain isotherms of
similar shape, which are qualitatively in good agreement with recent
theoretical predictions. From the relative pressure range of the
liquid filled mesopores a pore load modulus of 1.5 GPa is
determined. The relative pressure region of mono- and multilayer
formation, however, reveals differences between the two independent
methods. In particular, the net strain at saturation pressure is
considerably larger for in-situ dilatometry. We attribute this
observation to the different sensitivity of the two methods to
anisotropic deformation in the hierarchical solid framework. While
in-situ SAXS measures the mesopore lattice strain and is therefore
exclusively sensitive to radial deformation of the struts, dilatometry
measures the linear deformation of the isotropic macroscopic sample,
being sensitive to the volumetric strain of the whole network.
Prevalence of silent vertebral fractures detected by vertebral fracture assessment in young Portuguese men with hyperthyroidism
Authors: Barbosa Ana Paula , Rui Mascarenhas Mário , Silva Carlos Francisco , Távora Isabel , Bicho Manuel , do Carmo Isabel , de Oliveira António Gouveia 
Published: January 2015

BackgroundHyperthyroidism is a risk factor for reduced bone mineral density (BMD) and osteoporotic fractures. Vertebral fracture assessment (VFA) by dual-energy X-ray absorptiometry (DXA) is a radiological method of visualization of the spine, which enables patient comfort and reduced radiation exposure.ObjectivesThis study was carried out to evaluate BMD and the prevalence of silent vertebral fractures in young men with hyperthyroidism.DesignWe conducted a cross-sectional study in a group of Portuguese men aged up to 50 years and matched in hyperthyroidism (n=24) and control (n=24) groups.Materials and methodsA group of 48 Portuguese men aged up to 50 years was divided and matched in hyperthyroidism (n=24) and control (n=24) groups. BMD (g/cm2) at L1–L4, hip, radius 33%, and whole body as well as the total body masses (kg) were studied by DXA. VFA was used to detect fractures and those were classified by Genant's semiquantitative method. No patient had previously been treated for hyperthyroidism, osteoporosis, or low bone mass. Adequate statistical tests were used.ResultsThe mean age, height, and total fat mass were similar in both groups (P≥0.05). The total lean body mass and the mean BMD at lumbar spine, hip, and whole body were significantly decreased in the hyperthyroidism group. In this group, there was also a trend for an increased prevalence of reduced BMD/osteoporosis and osteoporotic vertebral fractures.ConclusionsThe results obtained using VFA technology (confirmed by X-ray) suggest that the BMD changes in young men with nontreated hyperthyroidism may lead to the development of osteoporosis and vertebral fractures. This supports the pertinence of using VFA in the routine of osteoporosis assessment to detect silent fractures precociously and consider early treatment.
Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome
Authors: Zhang Yujin , Liu Hongwei , He Jin , Xu Kelei , Bai Huai , Wang Ying , Zhang Feng , Zhang Jinxia , Cheng Li , Fan Ping 
Published: January 2015

ObjectiveTo study the relationship between the lactonase activities and status of paraoxonase 1 (PON1) and its association with the PON1 genetic polymorphisms in women with polycystic ovarian syndrome (PCOS).DesignA case–control study.MethodsA total of 455 PCOS patients and 441 control women were included in this study. The lactonase activities and concentrations of PON1 were assayed using 5-thiobutyl butyrolactone (TBBL) and 7-O-diethylphosphoryl-3-cyano-4-methyl-7-hydroxycoumarin (DEPCyMC) respectively. A normalized lactonase activity (NLA) was estimated based on the ratio of TBBLase:DEPCyMCase activity. The PON1 genotypes, serum malondialdehyde (MDA) levels and total antioxidant capacity were analyzed.ResultsThe lactonase activities and levels of PON1 were higher in PCOS patients than in the control women. However, the NLA did not significantly differ between groups. The −108C→T variation of the PON1 gene showed decreased lactonase activities and levels of PON1 in a genotype-dependent manner (CC>CT>TT); the 192Q→R variation of the PON1 gene showed increased PON1 lactonase activities and NLA; and the 55L→M variation of the PON1 gene showed decreased lactonase activities and levels of PON1 but an increased NLA. A multivariable regression analysis showed that the −108C/T, 192Q/R, and 55L/M variations of the PON1 gene, serum apolipoprotein A1, and MDA levels were significant predictors of PON1 lactonase activity, PON1 level, and NLA.ConclusionsThe serum lactonase activities and concentrations of PON1 are increased in PCOS patients. The increased oxidative stress and the −108C/T, 192Q/R, and 55L/M genetic polymorphisms of PON1 may be associated with these changes.
On inverse topology problem for Laplace operators on graphs
Authors: Ershova Yu.Yu. , Karpenko I.I. , Kiselev A.V. 
Published: January 2015

Laplacian operators on finite compact metric graphs are considered under the assumption that matching conditions at graph vertices are of $\delta$ type. Under one additional assumption, the inverse topology problem is treated. Using the apparatus of boundary triples, we generalize and extend existing results on necessary conditions of isospectrality of two Laplacians defined on different graphs. A result is also given covering the case of Schrodinger operators.
Problem for hyperbolic system of equations having constant coefficients with integral conditions with respect to the time variable
Authors: Kuz A.M. , Ptashnyk B.Yo. 
Published: January 2015

In a domain specified in the form of a Cartesian product of a segment $\left[0,T\right]$ and the space ${\mathbb R}^{p}$, we study a problem with integral conditions with respect to the time variable for hyperbolic system with constant coefficients in a class of almost periodic functions in the space variables. A criterion for the unique solvability of this problem and sufficient conditions for the existence of its solution are established. To solve the problem of small denominators arising in the construction of solutions of the posed problem, we use the metric approach.
Around $P$-small subsets of groups
Authors: Protasov I.V. , Protasova K.D. 
Published: January 2015

A subset $X$ of a group $G$ is called $P$-small (almost $P$-small) if there exists an injective sequence $(g_{n})_{n\in\omega}$ in $G$ such that the subsets $(g_{n}X)_{n\in\omega}$ are pairwise disjoint ($g_{n}X\cap g_{m}X$ is finite for all distinct $n,m$), and weakly $P$-small if, for every $n\in\omega$, there exist $g_{0}, \ldots ,g_{n}\in G$ such that the subsets $g_{0} X, ..., g_{n} X$ are pairwise disjoint. We generalize these notions and say that $X$ is near $P$-small if, for every $n\in\omega$, there exist $g_{0}, \ldots ,g_{n}\in G$ such that $g_{i}X\cap g_{j}X$ is finite for all distinct $i,j \in\{0,\ldots, n\}$. We study the relationships between near $P$-small subsets and known types of subsets of a group, and the behavior of near $P$-small subsets under the action of the combinatorial derivation and its inverse mapping.
Stability of tripled fixed point iteration procedures for mixed monotone mappings
Authors: Timis I. 
Published: January 2015

Recently, Berinde and Borcut [Berinde, V. and Borcut, M., Tripled fixed point theorems for contractive type mappings in partially ordered metric spaces, Nonlinear Anal. 74 (2011), 4889-4897] introduced the concept of tripled fixed point and by now, there are several researches on this subject, in partially metric spaces and in cone metric spaces. In this paper, we introduce the notion of stability definition of tripled fixed point iteration procedures and establish stability results for mixed monotone mappings which satisfy various contractive conditions. Our results extend and complete some existing results in the literature. An illustrative example is also given.
OPTIMIZATION OF BACTERIOCIN PRODUCTION BY Lactococcus lactis ssp. lactis CN1.10a ORIGIN FROM RUSIPS
Authors: Indriati Ninoek , Kusmarwati Arifah , Hermana Irma 
Published: January 2015

Previous study of bacteriocin production on laboratory scale (100 mL) that used MRS broth medium produced unstable activity of bacteriocin. Therefore, this study aims to determine the optimum growth conditions and media for production of bacteriocin. Bacteria used in this research was a lactic acid bacteria (LAB) Lactococcus lactis ssp. lactis CN1.10a isolated from rusip, a traditional Bangkanese fermented fish product.The bacteria was first cultivated for subsequent use of bacteriocins production on intermediate scale (2L). Followed by the optimization of temperature, pH and medium for the bacteriocin production, determination of cell growth curve, bacteriocin production curve, bacteriocin activity on that scale, and also stability of bacteriocin during storage.The results showed that the optimum temperature and pH for the growth of producer cell were 28°C and pH 6. The greatest activity of bacteriocin was produced on CM medium (1% sucrose, 0,45% peptone, 1% yeast extract, 2,84% KH2PO4, 0,2% NaCl and 0,02% MgSO4.7H20) in addition of sucrose as carbohydrate source. Based on the growth curve performedon CM medium with KH2PO4, the L. Lactis ssp lactis CN1.10a was relatively stable up to 48 hours. Bacteriocin produced by the cell was 8000 AU/mlat24th hour.Bacteriocin was relatively stable when stored at -20°C for 1month with a relative activity of 69,4%.
OPTIMIZATION OF ENZYMATIC HYDROLYSIS OF FISH PROTEIN HYDROLYSATE (FPH) PROCESSING FROM WASTE OF CATFISH FILLET PRODUCTION
Authors: Utomo Bagus Sediadi Bandol , Suryanigrum Theresia Dwi , Harianto Herbert R 
Published: January 2015

An experiment to determine the optimum condition of fish protein hydrolysate (FPH) processing has been conducted to produce FPH with high protein content. The raw material was catfish (Pangasius sp.) waste from catfish fillet production. Fat content, sensory (color, odor and flavor), total number of bacteria (TPC) and E. coli were analyzed as supporting parameters. The experiment was initiated with preliminary experiment to determine the optimum temperature (temp variation: 50oC, 55oC, 60oC, and 65oC) and concentration of commercial papain enzyme (conc variation: 4%, 6%, and 8%) in FPH hydrolysis, while the main experiment was to determine the optimum time of hydrolysis (time variation: 6, 12, 24, 36, and 48 hours), and pH (pH variation: 5 and 7). Results showed that the optimum temperature in preliminary experiment was 60oC and optimum concentration of enzyme was 4%, whereas the main experiment resulted the optimum hydrolysis time of 48 hours and optimum pH of 5. This condition produced FPH with protein content of 1.21% wet weight basis (wb) or 39.03% dry weight basis (db) and fat content of 0.16% wb (5.16% db). The sensory analysis of the end product revealed that from max score of 5, the scores of color, odor and flavor of the FPH were 3.50, 2.17 and 2.29, respectively. The product had TPC of 1.1x 107CFU/g with no E. coli infection.
INITIAL EXPERIENCE WITH ENDOSCOPIC ULTRASOUND-GUIDED FINE NEEDLE ASPIRATION OF RENAL MASSES: indications, applications and limitations
Authors: MOURA Renata Nobre , LOPES Roberto Iglesias , SROUGI Miguel , DALL'OGLIO Marcos Francisco , SAKAI Paulo , ARTIFON Everson L A 
Published: January 2015

Context Tissue sampling of renal masses is traditionally performed via the percutaneous approach or laparoscopicaly. The utility of endoscopic ultrasound to biopsy renal lesions it remains unclear and few cases have been reported. Objectives To evaluate the feasibility and outcome of endoscopic ultrasound fine needle aspiration of renal tumors. Methods Consecutive subjects undergoing attempted endoscopic ultrasound fine needle aspiration of a kidney mass after evaluation with computerized tomography or magnetic resonance. Results Ten procedures were performed in nine male patients (median age 54.7 years) on the right (n = 4) and left kidney (n = 4) and bilaterally (n = 1). Kidney masses (median diameter 55 mm ; range 13-160 mm) were located in the upper pole (n = 3), the lower pole (n = 2) and the mesorenal region (n = 3). In two cases, the mass involved more than one kidney region. Surgical resection confirmed renal cell carcinoma in six patients in whom pre-operative endoscopic ultrasound fine needle aspiration demonstrated renal cell carcinoma. No complications were reported. Conclusions Endoscopic ultrasound fine needle aspiration appears as a safe and feasible procedure with good results and minimal morbidity.
Kinematic Analysis of Cpm Machine Supporting to Rehabilitation Process after Surgical Knee Arthroscopy and Arthroplasty
Authors: Trochimczuk R. , Kuźmierowski T. 
Published: January 2015

Abstract
Existing commercial solutions of the CPM (Continuous Passive Motion) machines are described in the paper. Based on the analysis of existing solutions we present our conceptual solution to support the process of rehabilitation of the knee joint which is necessary after arthroscopic surgery. For a given novel structure we analyze and present proprietary algorithms and the computer application to simulate the operation of our PCM device. In addition, we suggest directions for further research.
Drought Severity and its Effect on Agricultural Production in the Hungarian-Serbian Cross-Border Area
Authors: Fiala Károly , Blanka Viktória , Ladányi Zsuzsanna , Szilassi Péter , Benyhe Balázs , Dolinaj Dragan , Pálfai Imre 
Published: January 2015

Abstract
Several environmental and economic consequences of drought and the accompanying water shortage were observed in the plain area of the Carpathian Basin in the last decades. This area is mostly used for agriculture, thus it is a key problem in the future to maintain food safety in the changing circumstances. Therefore, involvement and identification of areas affected by drought hazard and revealing steps of efficient adaptation are of high importance. In this study influence of drought severity on agricultural production is investigated in the Hungarian-Serbian cross-border area. The tendency in drought severity was analysed by PaDI and MAI drought indices. The effect of drought on agricultural production is evaluated on maize yield data as the most drought sensitive crop in the region. Increasing drought frequency and severity was indicated for the study area for the period of 1961-2012. The spatial assessment of annual PaDI maps revealed the higher exposure of the north and northeastern part of the study area to drought, where drought frequency was also experienced to be the highest. Increased sensitivity was detected based on maize yield loss after the early 1990s and annual yields were in strong connection with d rought severity. In spite of the technological development of agriculture, environmental factors still substantially affect crop yie lds. The observed unfavourable changes in the region mean that water management and spatial planning faces conceptual challenges to prevent and mitigate the damages of drought.
Nonlinear Stability Of Free Thin Films: Thermocapillary And Van-Der-Waals Effects
Authors: Tabakova S. , Radev S. 
Published: January 2015

Abstract
In the present work the dynamics of a non-isothermal thin viscous film, with fully mobile interfaces, is studied in the case when the inertial, viscous, capillary, van der Waals and thermocapillary forces are important. The film is laterally bounded by a frame, whose temperature is higher than the environmental one. The stability of the static film shapes is examined numerically by a linear and non-linear analysis. The results show that the film rupture is mostly governed by the dynamics, but it could be delayed or enhanced by the thermocapillary convection and the heat transfer with the surrounding environment.
Taxonomic features of fruits and seeds of Nymphaea and Nuphar taxa of the Southern Baltic region
Authors: Latowski Karol , Toma Cezary , Dąbrowska Magdalena , Zviedre Egita 
Published: January 2015

Abstract
Research was carried out on fruits and seeds of Nymphaea and Nuphar taxa collected from Poland, Latvia and Estonia. The aim of the research was to establish diagnostic features which could enable identification of the examined taxa on the basis of the fruit and seed structure and creating a key to identify them. The examined organs were observed through an optic microscope and scanning electron microscope (SEM). New diagnostic features were discovered: spotting of fresh pericarp, the range of the fruit shape coefficient, the colour of the rays in the fruit stigma disc, the thickness of the seed testa, ribs in the seeds, and occurrence of the “puzzle shaped” cells on the surface of the testa. The discovered features were used in the taxonomic characteristics.
Panaeolus subfirmus (Agaricales, Basidiomycota), a species new for Poland
Authors: Halama Marek 
Published: January 2015

Abstract Panaeolus subfirmus P. Karst. is reported for the first time from Poland, and described and illustrated based on Polish specimens. Its ecology, general distribution and taxonomy are also presented. A key for determination all Polish species of Panaeolus (Fr.) Quél. is provided.
The Impact of Climate Change on the Eutrophication of Water Ecosystems in the Southern Part of the Republic of Moldova
Authors: Nedealcov Maria , Drumea Dumitru 
Published: January 2015

Abstract
The accelerating pace of climate change mainly on the adjacent territory of the Danube basin, contribute to the essential eutrophication of water basins within the region. The results indicate that air temperature recorded a double warming compared to territories from the central part of the country. On the background the accelerated warming there is a declining trend and of annual rainfall amounts. These climate changes, especially in recent decades have led to significant increase of water temperature in rivers and lakes. Thus, it constituted in the years 1990-2000 by 0.7 and 1.50C compared to the period 1980-1990, and by 1.0...2,00C accordingly in the years 2000-2013 compared to the previous decade. The significant increase of temperature during the last decade contributed to the intensification of algae growth and together with other factors contributed to the increase by about 20% of the nitrogen content, thus ensuring the ―flowering‖ with 50% of the water bodies’ volume.
Considerations on Recent Freezing Phenomena on Bistriţa and Bistricioara Rivers
Authors: Găman C. 
Published: January 2015

Abstract
It is highly important to have a better knowledge of river systems during the seasons when air temperature drops below freezing point if we consider the difficulties posed to hydrotechnical exploitations and the destruction caused by floods (as a result of ice jam development). The article presents briefly some opinions and hypotheses various researchers have formulated over time on the genesis of ice formations on rivers. Moreover, the article includes several analyses of ice formations developed on the Bistriţa and Bistricioara rivers as wells as hazardous winter phenomena that may cause such ice formations, e.g., ice jams (ice dams). The development of winter-specific phenomena on the two rivers during the winter of 2011 - 2012 is illustrated in pictures, graphs, and maps taken or developed on the basis on data collected in situ during research.
The Effect of Peat and Vermicompost Cavitation Products on the Soil Biological Activity
Authors: Steinberga Vilhelmine , Dubova Laila , Alsina Ina , Gmizo Galina , Malecka Solveiga 
Published: January 2015

Abstract
Commercial products with humic substances have often been recommended for plant growth stimulation and yield improvement. The aim of this study was to clarify the effects of two products, containing cavited peat and vermicompost respectively on the soil biological activity. Vegetation experiments with garden cress and cucumbers were arranged in pots with a peat substratum in the greenhouses of the Latvia University of Agriculture. The plants were treated with the preparations once a month. The first treatment was done at sowing. Dose of 20, 2, 0.2 mL per m2 during each treatment time were used. A control variant was without peat or vermicompost preparation. Field experiments with onions were carried out in the organic farming experimental field of the Latvia State Institute of Cereal Breeding. Plant growth and soil (substratum) biological activity (respiration and enzymatic activity) were tested. Plant growth and response to the different preparations depended on the plant species and its development stage. The effect of preparations decreases during plant development. The impact of peat or vermicompost preparation on soil biological activity depended not only on the concentration of preparation, but was influenced by the soil or growth media type. The decrease of onion yield in field conditions as a result of preparations was observed.