bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRAIL and Noxa Are Selectively Upregulated in Prostate Cancer Cells Downstream of the RIG-I/MAVS Signaling Pathway by Nonreplicating Sendai Virus Particles
Authors: Matsushima-Miyagi Taeko , Hatano Koji , Nomura Motonari , Li-Wen Liu , Nishikawa Tomoyuki , Saga Kotaro , Shimbo Takashi , Kaneda Yasufumi 
Published: September 2012

Abstract
Purpose: The treatment of cancer with oncolytic viruses primarily depends on the selective viral replication in cancer cells. However, a replication-incompetent hemagglutinating virus of Japan (HVJ; Sendai virus) envelope (HVJ-E) suppresses the growth of human cancer cells as effectively as replication-competent live HVJ without producing toxic effects in nonmalignant cells. Here, we analyze the molecular mechanism of the oncolytic activity of HVJ-E.
Experimental Design: The molecules responsible for HVJ-E–induced cancer cell death were elucidated in prostate cancer cell lines, and the effect of HVJ-E on orthotopic prostate cancers was evaluated in nonobese diabetic-severe combined immunodeficient (NOD-SCID) mice.
Results: The liposome-mediated transfer of viral RNA genome fragments from HVJ-E suppressed the viability of prostate cancer cells but not the viability of the noncancerous prostate epithelium. Knockdown experiments using siRNAs showed that the cancer cell–selective killing induced by HVJ-E was mediated by retinoic acid–inducible gene I (RIG-I) and mitochondrial antiviral signaling protein (MAVS). Downstream of the RIG-I/MAVS pathway, both TNF-related apoptosis-inducing ligand (TRAIL) and Noxa were upregulated by HVJ-E in the castration-resistant prostate cancer cell line PC3 but not in the noncancerous prostate epithelial cell line PNT2. TRAIL siRNA but not Noxa siRNA significantly inhibited HVJ-E–induced cell death in PC3 cells. However, Noxa siRNA effectively suppressed HVJ-E–induced cell death in DU145 cells, another castration-resistant prostate cancer cell line, in which Noxa but not TRAIL was upregulated by HVJ-E. Furthermore, the orthotopic prostate cancers were dramatically eradicated in immunodeficient mice injected with HVJ-E.
Conclusion: The RIG-I/MAVS signaling pathway represents an attractive target for cancer therapy. Clin Cancer Res; 18(22); 6271–83. ©2012 AACR.
Rossby Wave Breaking and Transport between the Tropics and Extratropics above the Subtropical Jet
Authors: Homeyer Cameron R. , Bowman Kenneth P. 
Published: September 2012

AbstractRossby wave breaking is an important mechanism for the two-way exchange of air between the tropical upper troposphere and lower stratosphere and the extratropical lower stratosphere. The authors present a 30-yr climatology (1981–2010) of anticyclonically and cyclonically sheared wave-breaking events along the boundary of the tropics in the 350–500-K potential temperature range from ECMWF Interim Re-Analysis (ERA-Interim). Lagrangian transport analyses show net equatorward transport from wave breaking near 380 K and poleward transport at altitudes below and above the 370–390-K layer. The finding of poleward transport at lower levels is in disagreement with previous studies and is shown to largely depend on the choice of tropical boundary. In addition, three distinct modes of transport for anticyclonic wave-breaking events are found near the tropical tropopause (380 K): poleward, equatorward, and symmetric. Transport associated with cyclonic wave-breaking events, however, is predominantly poleward. The three transport modes for anticyclonic wave breaking are associated with specific characteristics of the geometry of the mean flow. In particular, composite averages show that poleward transport is associated with a “split” subtropical jet where the jet on the upstream side of the breaking wave extends eastward and lies poleward and at lower altitudes of the subtropical jet on the downstream side, producing a substantial longitudinal overlap between the two jets. Equatorward transport is not associated with a split subtropical jet and is found immediately downstream of stationary anticyclones in the tropics, often associated with monsoon circulations. It is further shown that, in general, the transport direction of breaking waves is determined primarily by the relative positions of the jets.
Measurement of Atmospheric Aspect Sensitivity Using Coherent Radar Imaging after Mitigation of Radar Beam Weighting Effect
Authors: Chen Jenn-Shyong , Furumoto Jun-ichi 
Published: September 2012

Abstract
The aspect angle, a measurement of the aspect sensitivity of atmospheric refractivity irregularities, was estimated with multiple-receiver coherent radar imaging (CRI) of very high frequency (VHF) atmospheric radar. Two CRI parameters retrieved by Capon’s method were utilized to derive the aspect angle: brightness width from the vertical radar beam and the direction of arrival (DOA) of the echo center from the oblique radar beam. Differing from previous studies with CRI, the radar beam weighting effect on the CRI brightness distribution was considered, and moreover, the radar beamwidth used in study was adaptive to the signal-to-noise ratio (SNR) of data as well as the off-beam direction angle. The study is based on statistical results. It is shown that the brightness width, a representative of the aspect angle, obtained from the modified CRI brightness distribution of the vertical radar beam was generally larger than that without correction, and it was very close to the values derived from the DOA of the 1° oblique radar beam and the power distribution of multiple beam directions. Moreover, the aspect angle derived from the DOA varied with the radar beam direction, which was similar to that obtained from the comparison of echo powers of a radar beam pair; however, the DOA approach yielded a much larger aspect angle in the low-SNR condition. This study recommended a feasibility of improving the measurements of atmospheric parameters with CRI after removing the radar beam weighting effect suitably from the CRI brightness distribution.
A Surface Mooring for Air–Sea Interaction Research in the Gulf Stream. Part II: Analysis of the Observations and Their Accuracies
Authors: Bigorre Sébastien P. , Weller Robert A. , Edson James B. , Ware Jonathan D. 
Published: September 2012

Abstract
A surface mooring was deployed in the Gulf Stream for 15 months to investigate the role of air–sea interaction in mode water formation and other processes. The accuracies of the near-surface meteorological and oceanographic measurements are investigated. In addition, the impacts of these measurement errors on the estimation and study of the air–sea fluxes in the Gulf Stream are discussed. Pre- and postdeployment calibrations together with in situ comparison between shipboard and moored sensors supported the identification of biases due to sensor drifts, sensor electronics, and calibration errors. A postdeployment field study was used to further investigate the performance of the wind sensors. The use of redundant sensor sets not only supported the filling of data gaps but also allowed an examination of the contribution of random errors. Air–sea fluxes were also analyzed and computed from both Coupled Ocean–Atmosphere Response Experiment (COARE) bulk parameterization and using direct covariance measurements. The basic conclusion is that the surface buoy deployed in the Gulf Stream to support air–sea interaction research was successful, providing an improved 15-month record of surface meteorology, upper-ocean variability, and air–sea fluxes with known accuracies. At the same time, the coincident deployment of mean meteorological and turbulent flux sensors proved to be a successful strategy to certify the validity of the bulk formula fluxes over the midrange of wind speeds and to support further work to address the present shortcomings of the bulk formula methods at the low and high wind speeds.
Assimilation of Precipitation-Affected Radiances in a Cloud-Resolving WRF Ensemble Data Assimilation System
Authors: Zhang Sara Q. , Zupanski Milija , Hou Arthur Y. , Lin Xin , Cheung Samson H. 
Published: September 2012

Abstract
Assimilation of remotely sensed precipitation observations into numerical weather prediction models can improve precipitation forecasts and extend prediction capabilities in hydrological applications. This paper presents a new regional ensemble data assimilation system that assimilates precipitation-affected microwave radiances into the Weather Research and Forecasting Model (WRF). To meet the challenges in satellite data assimilation involving cloud and precipitation processes, hydrometeors produced by the cloud-resolving model are included as control variables and ensemble forecasts are used to estimate flow-dependent background error covariance. Two assimilation experiments have been conducted using precipitation-affected radiances from passive microwave sensors: one for a tropical storm after landfall and the other for a heavy rain event in the southeastern United States. The experiments examined the propagation of information in observed radiances via flow-dependent background error auto- and cross covariance, as well as the error statistics of observational radiance. The results show that ensemble assimilation of precipitation-affected radiances improves the quality of precipitation analyses in terms of spatial distribution and intensity in accumulated surface rainfall, as verified by independent ground-based precipitation observations.
Did the Arctic Ice Recover? Demographics of True and False Climate Facts
Authors: Hamilton Lawrence C. 
Published: September 2012

Abstract
Beliefs about climate change divide the U.S. public along party lines more distinctly than hot social issues. Research finds that better-educated or informed respondents are more likely to align with their parties on climate change. This information–elite polarization resembles a process of biased assimilation first described in psychological experiments. In nonexperimental settings, college graduates could be prone to biased assimilation if they more effectively acquire information that supports their beliefs. Recent national and statewide survey data show response patterns consistent with biased assimilation (and biased guessing) contributing to the correlation observed between climate beliefs and knowledge. The survey knowledge questions involve key, uncontroversial observations such as whether the area of late-summer Arctic sea ice has declined, increased, or declined and then recovered to what it was 30 years ago. Correct answers are predicted by education, and some wrong answers (e.g., more ice) have predictors that suggest lack of knowledge. Other wrong answers (e.g., ice recovered) are predicted by political and belief factors instead. Response patterns suggest causality in both directions: science information affecting climate beliefs, but also beliefs affecting the assimilation of science information.
Documentary Film from the Southern Cone during Exile (1970–1980)
Authors: Campo Javier 
Published: September 2012

Soon after the establishment of the Southern Cone dictatorships many artists and intellectuals, mostly political activists, had to go into exile. The documentary filmmakers among them continued to work in their countries of exile producing testimonies, denunciations, and reflections with their countries of origin as a central focus. An analysis of the most important works of the period called “film from exile,” from 1973 (Augusto Pinochet’s coup against Salvador Allende in Chile) to the democratic transitions taking place in the subcontinent in the mid- and late 1980s, reveals a progression in themes from militancy through reflection on the condition of exile to the defense of human rights. The documentary films from exile recorded the diversity of resources used by the filmmakers to bear witness to the absent, a rich palette that combined staging, archival material, interviews, and reflection to produce the only traces of free cinema during this period. Tan pronto se establecieron las dictaduras en el Cono Sur muchos artistas e intelectuales, la mayor parte activistas políticos, tuvieron que exilarse. Entre ellos, los documentalistas de documentales continuaron su labor en los países de exilio produciendo testimonios, denuncias y reflexiones con sus países de origen como enfoque principal. Un análisis de las obras mas importantes del período llamado “film desde el exilio,” de 1973 (el golpe de Augusto Pinochet en contra de Salvador Allende en Chile) a las transiciones democráticas que tomaron lugar en los fines de la década 1980, revela una progresión en los temas desde la militancia a través de reflexiones sobre las condiciones de exilio hasta la defensa de los derechos humanos. Los documentales del exilio abrevaron en la diversidad de recursos al alcance de los cineastas, una rica paleta que combinó material de archivo, entrevistas, y reflexiones para producir los únicos rasgos del cine libre durante este periodo.
Understanding Cultural Issues in the Diabetes Self-Management Behaviors of Korean Immigrants
Authors: Cha EunSeok , Yang Kyeongra , Lee Jia , Min Jiwon , Kim Kevin H. , Dunbar Sandra B. , Jennings Bonnie Mowinski 
Published: September 2012

Purpose The purpose of this study was to explore potential factors affecting the self-management behaviors of Korean immigrants with type 2 diabetes mellitus (KIT2Ds). Methods A qualitative descriptive design guided this study. Semistructured interviews lasting 45 to 60 minutes were conducted with 20 KIT2Ds in the participants’ preferred language; in all cases, this was Korean. Each interview was audiotaped, transcribed, and analyzed using conventional content analysis. Data analysis was performed in two steps. The data written in Korean were initially analyzed by 3 bilingual researchers. A qualitative researcher then participated in the analysis to refine the findings for presentation to an English-speaking audience while staying true to the data and preserving the nuanced Korean meanings. Results The mean age of the sample was 64. 5 ± 11.6 years (9 men and 11 women). The mean years of staying in the United States and age at diabetes mellitus diagnosis were 23.6 ± 9.7 years and 52.5 ± 12.3 years, respectively. Three major ideas were identified: (1) issues on treatment regimen related to medications and diet, (2) resources that helped or hindered ability to manage diabetes, and (3) the physician-patient relationship. Conclusions Important cultural nuances need to be addressed to better prepare KIT2Ds to manage their diabetes more effectively. A culture-specific program should extend beyond a diabetes self-management education delivered in Korean language. Rather, content and education methods need to consider acculturation effects on diabetes management behaviors.
Families United/Familias Unidas
Authors: Perez Siwik Violet , Kutob Randa M. , Ritenbaugh Cheryl , Aickin Mikel , Gordon Judith S. 
Published: September 2012

Purpose The purpose of this study is to describe the development and implementation of a new diabetes prevention intervention that combines the benefits of family support with the group office model. Intensive lifestyle modification can effectively delay the onset of type 2 diabetes, yet health providers are challenged in translating these results to their patients. The group outpatient visit model can provide a means to address prevention issues in a financially sustainable manner. Methods Materials from the Diabetes Prevention Program and a previously developed group office visit program were combined to create the Families United/Familias Unidas curriculum. The session content utilized a multiculturally tailored approach designed to help participants decrease portion size, decrease carbohydrate intake, increase physical activity, and increase resiliency. Adults aged 18 to 70 were recruited who had any diabetes risk factors but did not have diabetes. Eligible participants enlisted a support person, aged 14 to 70, to join them in the 6-month group office visit intervention. Results Twenty-nine pairs (n = 58) of primary participants plus support persons were recruited. Participants’ average age was 45; 74% were female; 56.9% identified themselves as white and 37.9% as Hispanic/Latino. Over one-third had 4 or more diabetes risk factors. Twelve family group office visits were delivered over 6 months. The attendance rate for those who attended at least one session was 72%. Conclusions Group office visits can provide a new sustainable model for diabetes prevention and are a natural fit for primary care physicians in collaboration with other health care professionals, such as dieticians or diabetes educators.
Magnetic Resonance Imaging After Arthroscopic Microfracture of Capitellar Osteochondritis Dissecans
Authors: Wulf Corey A. , Stone Rebecca M. , Giveans M. Russell , Lervick Gregory N. 
Published: September 2012

Background: Osteochondritis dissecans (OCD) of the capitellum affects young athletes involved in elbow load-bearing activities. Unstable lesions are best managed surgically, although debate remains regarding the optimal method. Arthroscopic treatment allows rapid recovery, but the effect on the articular surface is undetermined. Hypothesis: The clinical outcome after arthroscopic microfracture of stage III/IV capitellum OCD would be successful in terms of return to sport and restoration of function, and there would be some evidence of articular restoration or repair. Study Design: Case series; Level of evidence, 4. Methods: We reviewed records of 10 consecutive adolescent patients (age ≤18 years) with stage III or IV OCD lesions of the capitellum managed with arthroscopic microfracture. The mean age at the time of surgery was 13.9 years (range, 10.8-18.5 years); 7 patients were skeletally immature and 3 were skeletally mature. Pre- and postoperative functional assessment included active range of motion, Mayo Elbow Performance Score (MEPS), and Timmerman/Andrews elbow score. All patients underwent plain radiographic and magnetic resonance imaging (MRI) evaluation at a minimum of 12 months (mean, 27 months; range, 12-49 months) and clinical evaluation at a minimum of 24 months (mean, 42 months; range, 27-54 months) after surgery. Results: The mean range of motion improved in both flexion (135.8°→140.7°, P = .112) and extension (20.4°→–2.2°, P = .005). The mean MEPS (70.5→97, P = .007) and Timmerman/Andrews elbow scores (116.4→193.0, P = .008) improved significantly. magnetic resonance imaging (MRI) evaluation demonstrated an improvement in overall joint congruence and the formation of a reparative articular surface in 8 of 10 (80%) patients. No reoperations or major complications were encountered. Six of 8 patients involved in competitive athletics returned to the same level of participation at an average of 5.1 months. Conclusion: Arthroscopic OCD fragment excision and capitellar microfracture demonstrates good to excellent functional results in short-term follow-up. Follow-up MRI suggests potential for a reparative fibrocartilaginous articular surface. Longer term follow-up is necessary to determine durability of the technique.
Failure With Continuity in Rotator Cuff Repair “Healing”
Authors: McCarron Jesse A. , Derwin Kathleen A. , Bey Michael J. , Polster Joshua M. , Schils Jean P. , Ricchetti Eric T. , Iannotti Joseph P. 
Published: September 2012

Background: Ten to seventy percent of rotator cuff repairs form a recurrent defect after surgery. The relationship between retraction of the repaired tendon and formation of a recurrent defect is not well defined. Purpose/Hypotheses: To measure the prevalence, timing, and magnitude of tendon retraction after rotator cuff repair and correlate these outcomes with formation of a full-thickness recurrent tendon defect on magnetic resonance imaging, as well as clinical outcomes. We hypothesized that (1) tendon retraction is a common phenomenon, although not always associated with a recurrent defect; (2) formation of a recurrent tendon defect correlates with the timing of tendon retraction; and (3) clinical outcome correlates with the magnitude of tendon retraction at 52 weeks and the formation of a recurrent tendon defect. Study Design: Case series; Level of evidence, 4. Methods: Fourteen patients underwent arthroscopic rotator cuff repair. Tantalum markers placed within the repaired tendons were used to assess tendon retraction by computed tomography scan at 6, 12, 26, and 52 weeks after operation. Magnetic resonance imaging was performed to assess for recurrent tendon defects. Shoulder function was evaluated using the Penn score, visual analog scale (VAS) score for pain, and isometric scapular-plane abduction strength. Results: All rotator cuff repairs retracted away from their position of initial fixation during the first year after surgery (mean [standard deviation], 16.1 [5.3] mm; range, 5.7-23.2 mm), yet only 30% of patients formed a recurrent defect. Patients who formed a recurrent defect tended to have more tendon retraction during the first 6 weeks after surgery (9.7 [6.0] mm) than those who did not form a defect (4.1 [2.2] mm) ( P = .08), but the total magnitude of tendon retraction was not significantly different between patient groups at 52 weeks. There was no significant correlation between the magnitude of tendon retraction and the Penn score ( r = 0.01, P = .97) or normalized scapular abduction strength ( r = −0.21, P = .58). However, patients who formed a recurrent defect tended to have lower Penn scores at 52 weeks ( P = .1). Conclusion: Early tendon retraction, but not the total magnitude, correlates with formation of a recurrent tendon defect and worse clinical outcomes. “Failure with continuity” (tendon retraction without a recurrent defect) appears to be a common phenomenon after rotator cuff repair. These data suggest that repairs should be protected in the early postoperative period and repair strategies should endeavor to mechanically and biologically augment the repair during this critical early period.
The diuretic effect of urea analog dimethylthiourea in female Wistar rats
Authors: Cil O , Ertunc M , Onur R 
Published: September 2012

Urea plays an important role in the urinary concentrating mechanism in the kidney by contributing greatly in the generation of hyperosmolar medulla due to the presence of urea transporters, which mediate facilitated transport of urea. In this study, we investigated the possible diuretic effect of urea analog and urea transporter inhibitor, dimethylthiourea (DMTU), in rats. Female Wistar rats were divided into two groups, group 1 (control group, n = 7) rats were injected with saline intraperitoneally (i.p.), while group 2 (DMTU group, n = 7) rats were injected with 500 mg/kg DMTU (i.p.) and an additional dose of 125 mg/kg DMTU after 8 h. DMTU administration induced an approximately three times increase in daily urine volume ( p < 0.001) and decreased urine osmolality to approximately 35% of controls ( p < 0.0001). DMTU also increased free water clearance ( p < 0.0001) without a significant change in osmolar clearance. DMTU treatment caused an increase in urea clearance ( p < 0.05) and fractional excretion of urea ( p < 0.05) with a decrease in serum urea concentration ( p < 0.001). DMTU had no effect on creatinine clearance or serum electrolytes, creatinine levels and osmolality. With these findings, we report for the first time that DMTU has a prominent diuretic effect with increased urea excretion, which may be explained by the inhibitory effect of the drug on urea transporters. Our findings suggest that DMTU may be used as a diuretic agent and also could be used as a lead compound for the development of novel diuretics.