bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility Platform for Stroke Studies
Authors: Minnerup Jens , Trinczek Benjamin , Storck Michael , Hohenberger Maria , Wilpsbäumer Simon , Abdul-Rahim Azmil H. , Liesirova Kai Timo , Broeg-Morvay Anne , Meisterernst Julia , Lees Kennedy R. , Mattle Heinrich P. , Wersching Heike , Dziewas Rainer , Schäbitz Wolf-Rüdiger , Schilling Matthias 
Published: November 2014

Background and Purpose—
Eligibility criteria are a key factor for the feasibility and validity of clinical trials. We aimed to develop an online tool to assess the potential effect of inclusion and exclusion criteria on the proportion of patients eligible for an acute stroke trial.

Methods—
We identified relevant inclusion and exclusion criteria of acute stroke trials. Based on these criteria and using a cohort of 1537 consecutive patients with acute ischemic stroke from 3 stroke centers, we developed a web portal feasibility platform for stroke studies (FePASS) to estimate proportions of eligible patients for acute stroke trials. We applied the FePASS resource to calculate the proportion of patients eligible for 4 recent stroke studies.

Results—

Sixty-one eligibility criteria were derived from 30 trials on acute ischemic stroke. FePASS, publicly available at
http://fepass.uni-muenster.de
, displays the proportion of patients in percent to assess the effect of varying values of relevant eligibility criteria, for example, age, symptom onset time, National Institutes of Health Stroke Scale, and prestroke modified Rankin Scale, on this proportion. The proportion of eligible patients for 4 recent stroke studies ranged from 2.1% to 11.3%. Slight variations of the inclusion criteria could substantially increase the proportion of eligible patients.

Conclusions—
FePASS is an open access online resource to assess the effect of inclusion and exclusion criteria on the proportion of eligible patients for a stroke trial. FePASS can help to design stroke studies, optimize eligibility criteria, and to estimate the potential recruitment rate.
Patient Perspectives on Peer Mentoring
Authors: Lu Yang , Pyatak Elizabeth A. , Peters Anne L. , Wood Jamie R. , Kipke Michele , Cohen Marisa , Sequeira Paola A. 
Published: November 2014

Purpose The purpose of the study was to identify attitudes and topics relevant to peer mentoring as an adherence-promoting intervention for adolescents and young adults (YAs) with type 1 diabetes (T1D). Methods Self-administered survey data were collected in 2 diabetes clinics from a convenience sample of adolescents as prospective mentees (ages 13-18) and YAs as prospective mentors (ages 19-25) with T1D. Survey topics included demographics, disease history, glycemic control, adherence, depression, barriers to disease management, social support, and interest in peer mentoring. Descriptive statistical analyses, thematic coding, and stepwise multivariate logistic regression were performed. Results A majority of the 54 adolescents and 46 YAs expressed interest in a peer mentoring program. Having supportive friends and living in a large household positively predicted adolescent interest in having a peer mentor. Approximately one-third of all participants experienced social barriers to diabetes management. For adolescents, barriers included inflexible schedules, unfamiliar foods, and the embarrassment of checking blood glucose in front of others. Young adults reported barriers in tracking food consumption and remembering to check blood glucose. Various diabetes management skills were in high demand by adolescents, who especially desired to learn about managing T1D on their own and in college. Participants were open to multiple communication modes, including in-person meetings, phone, text messaging, and social media. Conclusions Many adolescents and young adults with T1D are interested in peer mentoring as a way to facilitate learning and sharing essential diabetes management skills and experiences.
The effects of aquatic therapy on mobility of individuals with neurological diseases: a systematic review
Authors: Marinho-Buzelli Andresa R , Bonnyman Alison M , Verrier Mary C 
Published: November 2014

Objective: To summarize evidence on the effects of aquatic therapy on mobility in individuals with neurological diseases. Data sources: MEDLINE, EMBASE, PsycInfo, CENTRAL, CINAHL, SPORTDiscus, PEDro, PsycBITE and OT Seeker were searched from inception to 15 September 2014. Hand-searching of reference lists was performed in the selected studies. Review methods: The search included randomized controlled trials and quasi-experimental studies that investigated the use of aquatic therapy and its effect on mobility of adults with neurological diseases. One reviewer screened titles and abstracts of retrieved studies from the search strategy. Two reviewers independently examined the full texts and conducted the study selection, data extraction and quality assessment. A narrative synthesis of data was applied to summarize information from included studies. The Downs and Black Scale was used to assess methodological quality. Results: A total of 116 articles were obtained for full text eligibility. Twenty studies met the specified inclusion criteria: four Randomized Controlled Trials (RCTs), four non-randomized studies and 12 before-and-after tests. Two RCTs (30 patients with stroke in the aquatic therapy groups), three non-randomized studies and three before-and-after studies showed “fair” evidence that aquatic therapy increases dynamic balance in participants with some neurological disorders. One RCT (seven patients with stroke in the aquatic therapy group) and two before-and-after tests (20 patients with multiple sclerosis) demonstrated “fair” evidence on improvement of gait speed after aquatic therapy. Conclusion: Our synthesis showed “fair” evidence supporting the use of aquatic therapy to improve dynamic balance and gait speed in adults with certain neurological conditions.
Promoting palliative care in the community: Production of the primary palliative care toolkit by the European Association of Palliative Care Taskforce in primary palliative care
Authors: Murray Scott A , Firth Adam , Schneider Nils , Van den Eynden Bart , Gomez-Batiste Xavier , Brogaard Trine , Villanueva Tiago , Abela Jurgen , Eychmuller Steffen , Mitchell Geoffrey , Downing Julia , Sallnow Libby , van Rijswijk Erik , Barnard Alan , Lynch Marie , Fogen Frederic , Moine Sébastien 
Published: November 2014

Background: A multidisciplinary European Association of Palliative Care Taskforce was established to scope the extent of and learn what facilitates and hinders the development of palliative care in the community across Europe. Aim: To document the barriers and facilitators for palliative care in the community and to produce a resource toolkit that palliative care specialists, primary care health professionals or policymakers, service developers, educationalists and national groups more generally could use to facilitate the development of palliative care in their own country. Design: (1) A survey instrument was sent to general practitioners with knowledge of palliative care services in the community in a diverse sample of European countries. We also conducted an international systematic review of tools used to identify people for palliative care in the community. (2) A draft toolkit was then constructed suggesting how individual countries might best address these issues, and an online survey was then set up for general practitioners and specialists to make comments. Iterations of the toolkit were then presented at international palliative care and primary care conferences. Results: Being unable to identify appropriate patients for palliative care in the community was a major barrier internationally. The systematic review identified tools that might be used to help address this. Various facilitators such as national strategies were identified. A primary palliative care toolkit has been produced and refined, together with associated guidance. Conclusion: Many barriers and facilitators were identified. The primary palliative care toolkit can help community-based palliative care services to be established nationally.
Clinician Perspectives on Delaying Initiation of Antiretroviral Therapy for Clinically Eligible HIV-Infected Patients
Authors: Beer Linda , Valverde Eduardo E. , Raiford Jerris L. , Weiser John , White Becky L. , Skarbinski Jacek 
Published: November 2014

Objectives: Guidelines for antiretroviral therapy (ART) initiation have evolved, but consistently note that adherence problems should be considered and addressed. Little is known regarding the reasons providers delay ART initiation in clinically eligible patients. Methods: In 2009, we surveyed a probability sample of HIV care providers in 582 outpatient facilities in the United States and Puerto Rico with an open-ended question about nonclinical reasons for delaying ART initiation in otherwise clinically eligible patients. Results: Very few providers (2%) reported never delaying ART. Reasons for delaying ART were concerns about patient adherence (68%), patient acceptance (60%), and structural barriers (33%). Provider and practice characteristics were associated with reasons for delaying ART. Conclusion: Reasons for delaying ART were consistent with clinical guidelines and were both patient level and structural. Providers may benefit from training and access to referrals for ancillary services to enhance their ability to monitor and address these issues with their patients.
An RCOR1 loss–associated gene expression signature identifies a prognostically significant DLBCL subgroup
Authors: Chan Fong Chun , Telenius Adele , Healy Shannon , Ben-Neriah Susana , Mottok Anja , Lim Raymond , Drake Marie , Hu Sandy , Ding Jiarui , Ha Gavin , Scott David W. , Kridel Robert , Bashashati Ali , Rogic Sanja , Johnson Nathalie , Morin Ryan D. , Rimsza Lisa M. , Sehn Laurie , Connors Joseph M. , Marra Marco A. , Gascoyne Randy D. , Shah Sohrab P. , Steidl Christian 
Published: November 2014

Key Points
Integration of genome-wide copy number and whole transcriptome data identifies key mutational events in the pathogenesis of DLBCL. Genomic deletions in RCOR1 are associated with a specific gene expression signature and with unfavorable clinical outcomes in DLBCL patients.
Risk of venous and arterial thrombotic events in patients diagnosed with superficial vein thrombosis: a nationwide cohort study
Authors: Cannegieter Suzanne C. , Horváth-Puhó Erzsébet , Schmidt Morten , Dekkers Olaf M. , Pedersen Lars , Vandenbroucke Jan P. , Sørensen Henrik T. 
Published: November 2014

Key Points
In the 3 months after isolated SVT, the risk of a deep venous event or pulmonary embolism is 3.4%. This risk remains fivefold increased more than 5 years after the superficial event.
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
Authors: Xu Bowen , On Doan M. , Ma Anqi , Parton Trevor , Konze Kyle D. , Pattenden Samantha G. , Allison David F. , Cai Ling , Rockowitz Shira , Liu Shichong , Liu Ying , Li Fengling , Vedadi Masoud , Frye Stephen V. , Garcia Benjamin A. , Zheng Deyou , Jin Jian , Wang Gang Greg 
Published: November 2014

Key Points
We characterize active vs inactive analog compounds suitable for inhibition of both PRC2-EZH2 and PRC2-EZH1 ex vivo and in vivo. This study is the first to show oral delivery of an EZH2 and EZH1 dual inhibitor as promising therapeutics for MLL-rearranged leukemia.
Functional normalization of 450k methylation array data improves replication in large cancer studies
Authors: Fortin Jean-Philippe , Labbe Aurélie , Lemire Mathieu , Zanke Brent W , Hudson Thomas J , Fertig Elana J , Greenwood Celia MT , Hansen Kasper D 
Published: November 2014

AbstractWe propose an extension to quantile normalization that removes unwanted technical variation using control probes. We adapt our algorithm, functional normalization, to the Illumina 450k methylation array and address the open problem of normalizing methylation data with global epigenetic changes, such as human cancers. Using data sets from The Cancer Genome Atlas and a large case–control study, we show that our algorithm outperforms all existing normalization methods with respect to replication of results between experiments, and yields robust results even in the presence of batch effects. Functional normalization can be applied to any microarray platform, provided suitable control probes are available.
SRST2: Rapid genomic surveillance for public health and hospital microbiology labs
Authors: Inouye Michael , Dashnow Harriet , Raven Lesley-Ann , Schultz Mark B , Pope Bernard J , Tomita Takehiro , Zobel Justin , Holt Kathryn E 
Published: November 2014

AbstractRapid molecular typing of bacterial pathogens is critical for public health epidemiology, surveillance and infection control, yet routine use of whole genome sequencing (WGS) for these purposes poses significant challenges. Here we present SRST2, a read mapping-based tool for fast and accurate detection of genes, alleles and multi-locus sequence types (MLST) from WGS data. Using >900 genomes from common pathogens, we show SRST2 is highly accurate and outperforms assembly-based methods in terms of both gene detection and allele assignment. We include validation of SRST2 within a public health laboratory, and demonstrate its use for microbial genome surveillance in the hospital setting. In the face of rising threats of antimicrobial resistance and emerging virulence among bacterial pathogens, SRST2 represents a powerful tool for rapidly extracting clinically useful information from raw WGS data.Source code is available from http://katholt.github.io/srst2/.
Existence of a nontrivial solution for a "Equation missing" -Laplacian equation with p-critical exponent in "Equation missing"
Authors: Chaves Marcio F , Ercole Grey , Miyagaki Olimpio H 
Published: November 2014

Abstract
In this paper we prove the existence of a nontrivial solution in

D

1
,
p

(

R
N

)
∩

D

1
,
q

(

R
N

)

for the following

(
p
,
q
)

-Laplacian problem:

{

−

Δ
p

u
−

Δ
q

u
=
λ
g
(
x
)

|
u
|

r
−
1

u
+

|
u
|

p
⋆

−
2

u
,

u
(
x
)
≥
0
,

x
∈

R
N

,

where

1
<
q
≤
p
<
r
+
1
<

p
⋆

:
=

N
p

N
−
p

,

p
<
N

,

λ
>
0

is a parameter,

Δ
m

u
:
=
div
(
|
∇
u

|

m
−
2

∇
u
)

is the m-Laplacian operator and

g
∈

L

p
⋆

p
⋆

−
r
−
1

(

R
N

)

is positive in an open set.

MSC: 35J92, 47J30.
Magnetic microrobot and its application in a microfluidic system
Authors: Wang Jingyi , Jiao Niandong , Tung Steve , Liu Lianqing 
Published: November 2014

Abstract
This paper researches the design and control method of a microrobot in a microfluidic system by electromagnetic field. The microrobot can move along the microchannel to a required position, and by changing the magnetic torque, the microrobot can also rotate in the microfluidic chip. As an application of the microrobot, it is used as a mobile micromixer to mix two solutions in the microfluidic chip, and the experimental results verify its effectiveness.
Graded behavioral responses and habituation to sound in the common cuttlefish, Sepia officinalis
Authors: Samson Julia E. , Mooney T. Aran , Gussekloo Sander W.S. , Hanlon Roger T. 
Published: November 2014

Abstract
Sound is a widely available and vital cue in aquatic environments yet most bioacoustic research has focused on marine vertebrates, leaving sound detection in invertebrates poorly understood. Cephalopods are an ecologically key taxon that likely use sound and may be impacted by increasing anthropogenic ocean noise, but little is known regarding their behavioral responses or adaptations to sound stimuli. These experiments identify the acoustic range and levels that elicit a wide range of secondary defense behaviors such as inking, jetting, and rapid coloration change. Secondarily, it was found that cuttlefish habituate to certain sound stimuli. The present study examined the behavioral responses of 22 cuttlefish (Sepia officinalis) to pure-tone pips ranging from 80-1000 Hz with sound pressure levels of 85–188 dB re 1 μPa rms and particle accelerations of 0-17.1 m.s-2. Cuttlefish escape responses (inking, jetting) were observed between frequencies of 80-300 Hz and at sound levels above 140 dB re 1 μPa rms and 0.01 m.s-2 (0.74 m.s-2 for inking responses). Body patterning changes and fin movements were observed at all frequencies and sound levels. Response intensity was dependent upon stimulus amplitude and frequency, suggesting that cuttlefish also possess loudness perception with a maximum sensitivity around 150 Hz. Cuttlefish habituated to repeated 200 Hz tone pips, at two sound intensities. Total response inhibition was not reached, however, and a basal response remained present in most animals. The graded responses provide a loudness sensitivity curve and suggest an ecological function for sound-use in cephalopods.
An Investigation on Temperature Distribution and Cooling Rate of ERW Pipes during TIG Welding
Authors: Bhattacharya Tathagata , Bandyopadhyay Asish , Pal Pradip Kumar 
Published: November 2014

AbstractThe present investigation deals with the determination of temperature profile and subsequent rates of cooling at certain points on the external surface along axis of an ERW pipe, during TIG welding. Two samples of different diameters of pipes of ASTM A 106 Gr. B, seamless type are selected for experimentation. The temperatures on the external surface at different locations on each of these seamless pipes (of different diameters) during welding have been measured with the help of digital pyrometers. The temperature variation along the axis of pipe from the weld arc has been presented. Thereafter, through separate analytical methods the temperature distribution across the external surface of the pipe for a given point heat source is theoretically calculated, and the results are compared with the previously found experimental values of temperatures. They are found to be well in agreement. Further, the rates of cooling of a pre-selected point on the pipe surface are experimentally and analytically determined under varying welding conditions and are compared likewise and are found to be in good agreement too.
Assessing metastasis risk after pre‐operative anti‐angiogenic therapy
Authors: Biziato Daniela , De Palma Michele 
Published: November 2014

Anti‐angiogenic drugs are approved for the treatment of several cancer types, generally in the inoperable locally advanced or metastatic setting and in combination with other anti‐cancer agents. Recent clinical studies also suggest that anti‐angiogenic drugs can be useful in the pre‐operative (neoadjuvant) setting, by facilitating the shrinkage of the primary tumour and its surgical resection. However, the effects of neoadjuvant anti‐angiogenic therapy on the ability of tumours to form distant metastases are unclear. In this issue of EMBO Molecular Medicine, Ebos et al () present carefully performed pre‐clinical studies in mice that analyse the effects of pre‐operative anti‐angiogenic therapy on tumour metastasis and survival.
Acute Compartment Syndrome in the Forearm with Extensor and Flexor Tendon Ruptures
Authors: Suzuki Taku , Takeda Kazuki , Iwamoto Takuji , Sato Kazuki , Nakamura Toshiyasu , Yoshida Hirobumi 
Published: November 2014

Case:
While working in a factory, a thirty-five-year-old man injured his right forearm and was then diagnosed with acute compartment syndrome. Ruptures of the flexor and extensor tendons were revealed via single volar and dorsal incisions. End-to-side transfer with use of the remaining extensor tendons was performed; the end of the extensor indicis proprius tendon was sutured to the side of the extensor digitorum communis tendon of the middle finger, and the extensor pollicis longus tendon was sutured to the extensor pollicis brevis tendon.

Conclusion:
In cases of high-energy injuries, associated tendon rupture should be considered.
Comparative study of the fungicide Benomyl toxicity on some plant growth promoting bacteria and some fungi in pure cultures
Authors: Elslahi Randa H. , Osman Awad G. , Sherif Ashraf M. , Elhussein Adil A. 
Published: November 2014

Abstract
Six laboratory experiments were carried out to investigate the effect of the fungicide Benomyl on pure cultures of some plant growth promoting bacteria (PGPB) and some fungi. The highest LD50 was recorded for Bacillus circulans and proved to be the most resistant to the fungicide, followed by Azospirillum braziliense, while Penicillium sp. was the most affected microorganism. LD50 values for the affected microorganisms were in 21-240 orders of magnitude lower in comparison with the LD50 value for Azospirillum braziliense. The results indicate a strong selectivity for Benomyl against Rhizobium meliloti and Penicillium sp. when compared to other microorganisms tested. The highest safety coefficient was recorded for Bacillus circulans followed by Azospirillum braziliense, while Rhizobium meliloti, showed the lowest safety coefficient value compared to other bacteria. The lowest toxicity index was recorded for Bacillus circulans and Azospirillum braziliense. The slope of the curves for Bacillus sp. and Rhizobium meliloti was steeper than that of the other curves, suggesting that even a slight increase of the dose of the fungicide can cause a very strong negative effect. In conclusion, Benomyl could be applied without restriction when using inocula based on growth promoting bacteria such as symbiotic nitrogen fixers (Rhizobium meliloti), non-symbiotic nitrogen fixers (Azospirillum braziliense) or potassium solibilizers (Bacillus circulans), given that the fungicide is applied within the range of the recommended field dose.
Exposure-dependent variation in cryolite induced lethality in the nontarget insect, Drosophila melanogaster
Authors: Podder Sayanti , Roy Sumedha 
Published: November 2014

Abstract
The starting point of toxicity testing of any chemical in an organism is the determination of its Lethal Concentration 50 (LC50). In the present study, LC50 of a fluorinated insecticide cryolite is determined in a non-target insect model, Drosophila melanogaster. Interestingly, the result shows that acute LC50 of cryolite was much greater in comparison to the chronic one in case of Drosophila larvae. Larvae which were exposed to 65,000 to 70,000 μg/ml cryolite through food showed 50% mortality after 18 hours of acute exposure, whereas only 150 to 160 μg/ml cryolite was sufficient to cause 50% mortality in case of chronic exposure. Thus cryolite in a small amount when applied once cannot produce noticeable changes in Drosophila, whereas the same amount when used continuously can be fatal. The non-feeding pupal stage was also seen to be affected by chemical treatment. This suggests that the test chemical affects the developmental fate and results in failure of adult emergence. Absence of chemical-induced mortality in adults assumes that the toxicity of cryolite might be restricted to the preimaginal stages of the organism. Reduction in body size of larvae after ingestion of cryolite (with food) in acute treatment schedule is another interesting finding of this study. Some individuals consuming cryolite containing food cannot survive whereas the few survivors manifest a significant growth retardation which might be due to a tendency of refusal in feeding. Hence the present findings provide a scope of assessment of risk of other similar non-target groups