bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Ynamides to Highly Substituted Benzo[b]furans: Gold(I)‐Catalyzed 5‐endo‐dig‐Cyclization/Rearrangement of Alkylic Oxonium Intermediates
Authors: Blanco Jaimes Maria Camila , Weingand Vanessa , Rominger Frank , Hashmi A. Stephen K. 
Published: August 2013

AbstractA series of arylynamides with alkyloxy groups at the ortho position of the aryl group was prepared through a short alkylation/cross‐coupling/amidation sequence. The gold‐catalyzed conversion of these substrates combined both CO and CC formation steps, thus providing benzofurans with amine functionalities at the 2‐position and alkyl groups at the 3‐position. Cross‐over experiments showed that the alkyl‐migration step was an intermolecular process. X‐ray crystal‐structure analysis of two of the products supported our structural assignment. In some cases, the corresponding benzofurans without the alkyl group at the 3‐position were obtained as side‐products, which were formed through a competing protodeauration process.
Catalytic Functionalization of Oleyalcohol in Thermomorphic Solvent Systems for Synthesis of Potential Biotensides and Biomonomeres
Authors: Vorholt Andreas , Neubert Peter , Behr Arno 
Published: August 2013

AbstractEs werden zwei Funktionalisierungen des Oleylalkohols vorgestellt, die interessante Produkte für Anwendungen als Tenside und Biopolymere zugänglich machen. Die Tandemreaktion Hydroaminomethylierung konnte für das Amin Diethylamin mit hohen Ausbeuten optimiert werden. Die Hydroesterifizierung zeigt hohe Ausbeuten für verzweigte Hydroxyester. Es wird außerdem eine Trennung von Produkten und Katalysatoren in einem thermomorphen Lösungsmittelsystem gezeigt. Aufgrund der mittelpolaren Produkte zeigen sich aber hohe Leachingwerte in den Produktphasen.
Improving the quality of bone marrow assessment
Authors: Odejide Oreofe O. , Cronin Angel M. , DeAngelo Daniel J. , Bernazzoli Zachary A. , Jacobson Joseph O. , Rodig Scott J. , LaCasce Ann S. , Mazeika Teresa J. , Earles Kristofer D. , Abel Gregory A. 
Published: August 2013

BACKGROUNDSuccessful bone marrow assessment is essential to the diagnosis and staging of hematologic malignancies. The objective of this study was to determine whether specific operator techniques and/or use of a specimen preparation checklist could impact the quality of bone marrow assessment by reducing the frequency of nonspicular aspirates, small cores, and nondiagnostic samples.METHODSAll bone marrow biopsies performed at the Dana‐Farber Cancer Institute from April, 2012 to September, 2012 were eligible for inclusion. Six operator techniques were linked with specimen quality in a preintervention cohort. Next, a specimen preparation checklist was implemented, and outcomes were compared from the preintervention and postintervention cohorts.RESULTSIn total, 830 procedures performed by 41 operators were prospectively observed and analyzed. In the preintervention cohort (n = 413), no operator technique was associated with specimen quality in multivariable models accounting for patient characteristics and operator. Compared with the preintervention cohort, in multivariable analyses, the postintervention cohort (n = 417) had decreased odds of nondiagnostic specimens (odds ratio, 0.49; 95% confidence interval, 0.28‐0.87; P = .01) and core lengths ≤1 cm (odds ratio, 0.67; 95% confidence interval, 0.50‐0.90; P = .009), but there was no significant difference in spicularity.CONCLUSIONSVariation in the operator techniques studied did not have an impact on specimen quality, but implementation of a specimen preparation checklist significantly improved core length and frequency of diagnostic samples. Cancer 2013;119:3472–3478.. © 2013 American Cancer Society.
Epsilon aminocaproic acid prevents bleeding in severely thrombocytopenic patients with hematological malignancies
Authors: Antun Ana G. , Gleason Shannon , Arellano Martha , Langston Amelia A. , McLemore Morgan L. , Gaddh Manila , el Rassi Fuad , Bernal‐Mizrachi Leon , Galipeau Jacques , Heffner Leonard T. , Winton Elliott F. , Khoury Hanna J. 
Published: August 2013

BACKGROUNDDespite prophylactic platelet transfusions, bleeding remains a significant problem in thrombocytopenic patients.METHODSThe antifibrinolytic agent epsilon aminocaproic acid (EACA) was administered to 44 chronically (median duration, 273 days) and severely (platelet count, 8 × 109/L; range, 1 × 109/L‐ 19 × 109/L) thrombocytopenic patients with hematological malignancies. Prophylactic EACA at a dose of 1 g twice daily was orally administered for a median duration of 47 days (range, 7 days‐209 days) until the platelet count recovered to > 30; × 109/L. Platelets were only transfused if bleeding occurred.RESULTSWhile receiving EACA, 59% of the patients did not bleed, 25% had 19 episodes of spontaneously resolving minor bleeding that did not require platelet transfusion, and 16% received a median of 4 platelet transfusions (range, 1 transfusion‐8 transfusions) for 1 major traumatic and 9 spontaneous grade 2 to grade 3 bleeding (based on the World Health Organization classification of idiopathic thrombocytopenic purpura). No EACA toxicities were noted, and venous thromboses were not observed.CONCLUSIONSEACA is well tolerated and is associated with a low risk of major bleeding in patients with hematological malignancies who are experiencing chronic severe thrombocytopenia. Cancer 2013;119:3784–3787. © 2013 American Cancer Society.
Ofatumumab‐based chemoimmunotherapy is effective and well tolerated in patients with previously untreated chronic lymphocytic leukemia (CLL)
Authors: Shanafelt Tait , Lanasa Mark C. , Call Timothy G. , Beaven Anne W. , Leis Jose F. , LaPlant Betsy , Bowen Deborah , Conte Michael , Jelinek Diane F. , Hanson Curtis A. , Kay Neil E. , Zent Clive S. 
Published: August 2013

BACKGROUNDAlthough rituximab‐based chemoimmunotherapy (CIT) has substantially improved clinical outcomes in chronic lymphocytic leukemia (CLL), only 40% to 50% of patients achieve a complete remission (CR). There remains interest in identifying new approaches to improve the effectiveness of CIT. Ofatumumab is a fully human anti‐CD20 monoclonal antibody with greater apparent single‐agent activity than rituximab in CLL patients.METHODSPreviously untreated CLL patients in need of therapy received 6 cycles of CIT induction with pentostatin, cyclophosphamide, and ofatumumab (PCO) followed by response assessment.RESULTSOf the 48 patients enrolled, 77% completed PCO induction. Adverse events during induction included grade 3+ hematologic toxicity (27%) and grade 3+ nonhematologic toxicity (23%). Median CD4 count after induction and 6 months later were 186 × 106/L and 272 × 106/L. The overall response rate was 96% (46 of 48 patients), and the CR rate was 46% (22 of 48 patients). Among the 38 patients who underwent minimal residual disease evaluation, 7 (18%) were negative for minimal residual disease. After median follow‐up of 24 months, 10 (21%) patients have progressed and 8 (17%) have required retreatment. The efficacy and toxicity of ofatumumab‐based CIT compare favorably to our historical trials of rituximab‐based CIT using an identical chemotherapy backbone (n = 64). Time to retreatment also appeared longer for ofatumumab‐based CIT (free of retreatment at 24 months: 86% [95% confidence interval = 75‐99] versus 68% [95% confidence interval = 56‐81] for rituximab‐based CIT).CONCLUSIONSOfatumumab‐based CIT is well tolerated in patients with previously untreated CLL. The efficacy of ofatumumab‐based CIT compares favorably to historical trials of rituximab‐based CIT, suggesting randomized trials comparing ofatumumab‐based CIT and rituximab‐based CIT should be considered. Cancer 2013;119:3788–3796. © 2013 American Cancer Society.
Lenalidomide performance in the real world
Authors: Zeidan Amer M. , Gore Steven D. , McNally Diane L. , Baer Maria R. , Hendrick Franklin , Mahmoud Dalia , Davidoff Amy J. 
Published: August 2013

BACKGROUNDLenalidomide is approved for the treatment of anemia with transfusion dependence (TD) in patients with lower‐risk myelodysplastic syndrome (MDS) with 5q deletion (del5q‐MDS), but its “real‐life” use and effect on transfusion needs are unclear. In the current study, the authors examined its use in the Medicare population.METHODSPatients with MDS who were enrolled in Medicare Parts A, B, and D were identified using International Classification of Diseases 9‐Clinical Modification (ICD‐9) codes from 100% Medicare claims from 2006 through 2008. Patients were followed until the end of the study or death. Claims were used to determine time to initiation of lenalidomide, daily dose, duration, and other MDS therapies. Transfusion status was defined each week based on transfusion use in rolling 8‐week period: TD, required transfusions during 2 weeks, separated by ≥ 3 weeks; transfusion user (TU), 1 transfusion; and transfusion independence (TI), no transfusions.RESULTSA total of 753 of 23,855 patients (3.2%) received lenalidomide, including 31% of 470 patients with del5q‐MDS. At the time of lenalidomide initiation, 33% of patients were TD, 31% were TU, and 36% were TI. The median time to lenalidomide initiation was shorter for patients with del5q‐MDS than for other lower‐risk patients (8 weeks vs 20 weeks; P < .01). The percentage of patients with del5q‐MDS receiving lenalidomide increased over time. Lenalidomide initiation was found to be negatively associated with older age and baseline diabetes, stroke, and renal disease. During the observation period, 44% of TU/TD patients (53% of the patients with del5q‐MDS) achieved reductions in transfusion use; among TD patients receiving ≥ 3 cycles, 77% reduced their transfusion use and 40% achieved TI.CONCLUSIONSTo the authors' knowledge, the current study is the first report of lenalidomide use in a large Medicare‐enrolled population with MDS. Reductions in transfusion rates were overall consistent with data from clinical trials. Response rates were higher when ≥ 3 lenalidomide cycles were received. Cancer 2013;119:3870–3878. © 2013 American Cancer Society.
Clinical characteristics and outcomes with specific BRAF and NRAS mutations in patients with metastatic melanoma
Authors: Bucheit Amanda D. , Syklawer Erica , Jakob John A. , Bassett Roland L. , Curry Jonathan L. , Gershenwald Jeffrey E. , Kim Kevin B. , Hwu Patrick , Lazar Alexander J. , Davies Michael A. 
Published: August 2013

BACKGROUNDHotspot mutations in BRAF and NRAS are the most common somatic events in patients with melanoma. These mutations occur at highly conserved residues, but include several different substitutions. To determine whether specific mutations are clinically important to differentiate, tumor characteristics and clinical outcomes were compared among patients with advanced melanoma with 1) BRAF V600E versus V600K mutations and 2) NRAS exon 1 versus exon 2 mutations.METHODSRetrospective clinical and pathologic data were collected for patients with advanced melanoma with BRAF or NRAS mutations. The demographics, tumor characteristics, and clinical outcomes of the patients were compared to identify significant mutation‐specific associations.RESULTSAmong 302 patients with activating BRAF mutations, 76% had BRAF V600E and 24% had V600K substitutions. Compared with V600E, the presence of a V600K mutation was significantly associated with older age (median, 60.0 years vs 44.7 years; P < .001), male sex (80% vs 59%; P = .001), head/neck primary tumor location (30% vs 15%; P = .0026), shorter interval to stage IV disease (0.98 years vs 2.8 years; P = .015), and a shorter overall survival from the time of diagnosis of stage IV disease (median, 2.44 years vs 1.25 years; hazards ratio, 1.68 [P = .014]). Comparison of 136 patients with NRAS exon 1 (18%) and exon 2 (82%) mutations found an association with primary tumor histology (P = .0096) only.CONCLUSIONSThe presence of different substitutions at BRAF V600 correlates with patient demographics, tumor characteristics, and prognosis. These findings demonstrate the presence of mutation‐specific clinical differences between different BRAF genotypes in patients with melanoma, and support the incorporation of this information in patient evaluation and clinical trial design. Cancer 2013;119:3821–3829. © 2013 American Cancer Society.
Beitrag der Fugenmörtel zur Stabilität von Mauerwerk
Authors: Stürmer Sylvia 
Published: August 2013

AbstractDie Mauer‐/Fugenmörtel gewährleisten im Mauerwerk den Verbund zwischen den Mauersteinen. Die Arten der Mörtel und deren Verteilung im Mauerwerk hängen von den Steinarten, Formaten, Steinbearbeitungsstufen, Verbänden und Mauerwerksgefügen ab. Die Formate der Mauersteine und die Mörtel können je nach Bauwerk (Sakral‐/Profanbauten, Ingenieurbauwerke etc.), Alter und Baustil, Höhe und Lage des Bauteils sowie der regionalen Verfügbarkeit der Materialien stark variieren.Obwohl der Anteil des Mörtels am gesamten Mauerwerk im Verhältnis zu dem des Steins i. d. R. deutlich geringer ist, spielen die Art des neuen Fugenmörtels, dessen technische Eigenschaften und die stoffliche Verträglichkeit mit den Mauersteinen und Bestandsmörteln für die Stabilität und Dauerhaftigkeit des Mauerwerks eine große Rolle.Im folgenden Artikel wird auf die Auswahl von Mörteln für die nachträgliche Verfugung an Bestandsbauten, verschiedene Verarbeitungstechniken und Ausführungsdetails eingegangen.Contribution of joint mortars for stability of masonry construction. Jointing mortars connect the stone of masonry. The kinds of mortar and the joint compounds depend on the type of stones, its dimension, the stone working, the structure of masonry and its bond. The dimensions of stones and the mortar of historic masonry could vary a lot according to the kind of building, its age and architectural style, height and exposition as well as the availability of regional raw materials.The proportion of mortar compared to the proportion of stone within masonry is usually very low, but the compounds, chemical compatibility and technical properties of joints play an important role for the stability and durability of masonry.The paper deals with the choice of mortar for joint restoration at historic masonry, with different techniques and details of application.
Bestandserfassung mit Bauradar – ein zerstörungsfreies Verfahren für die Praxis
Authors: Patitz Gabriele 
Published: August 2013

AbstractBauen im Bestand bedeutet immer, die vorhandene Konstruktion und deren Baustoffe zu kennen. Zerstörungsfrei können mit dem Radarverfahren in kurzer Zeit große Flächen systematisch erfasst und beurteilt werden. Die heute vorhandene Technik und die vorliegenden Erfahrungen an zahlreichen Bauwerken ermöglichen deren erfolgreichen Einsatz. Kalibrierende Eingriffe und Öffnungen können auf ein Minimum reduziert und deren Position ganz gezielt ausgewählt werden. Wichtig ist aber der professionelle Einsatz dieser Technik von ausgewiesenen Spezialisten.Inventory with radar – a non‐destructive method for practice. Reconstruction always means to understand thoroughly the existing construction and its building materials. With non‐destructive‐testing for example by radar technique, large areas can be investigated and evaluated in this means. The modern techniques and a long‐term experience ensure successful applications. Destruction by openings and for calibration purposes can be cut down and the most useful position can be determined in advance. One of the most import points is the application of the method by trained specialists.
Ertüchtigung von gemauerten Bogentragwerken unter hohen Lasten
Authors: Bewer Andreas 
Published: August 2013

AbstractFür die Analyse gemauerter Bogentragwerke aus Natursteinen ist ein umfassender Kenntnisstand des Bestandes erforderlich. Das bedarf einer strukturierten Zusammenarbeit aller Fachdisziplinen, die sich mit der Erkundung und Beurteilung von Natursteinbauwerk beschäftigen. Bei der statischen Analyse sind die im 19. Jahrhundert entwickelten grafischen Verfahren hilfreich. Ihre Ergebnisse dienen als Eingangsgröße für elektronisch gestützte Modelle und deren Plausibilitätskontrolle. Aufgrund der potentiellen Kinematik von gemauerten Bogentragwerken kann ihre Traglast nur nichtlinear, also ohne Superposition der Lastfallergebnisse, ermittelt werden. Ist eine Stabilisierung eines gemauerten Bogentragwerks unumgänglich, so sollte ein biegesteifer Überbau in Betracht gezogen werden. Die Verstärkung von Bögen mit einer aufbetonierten Schale sollte vermieden werden.Retrofitting of masonry arch structures under high loads. For the analysis of masonry arch structures made of natural stone, a comprehensive knowledge of the existing structure is required. It needs a structured cooperation between all scientific disciplines that deal with the exploration and evaluation of natural stone buildings. The graphic methods developed in the 19th Century, are helpful. The results will serve as input for electronically supported models and their validation. Because of the potential kinematics of masonry arch structures, the collapse load can only be determined non‐linear, which means without superposition of the load case results. If a stabilisation of a masonry arch structure is inevitable, a more rigid superstructure should be considered. It should be avoided to reinforce the arch structure with a skin of ferroconcrete.
Spatial phenotypic and genetic structure of threespine stickleback (Gasterosteus aculeatus) in a heterogeneous natural system,LakeMývatn,Iceland
Authors: Millet Antoine , Kristjánsson Bjarni K. , Einarsson Árni , Räsänen Katja 
Published: August 2013

AbstractEco‐evolutionary responses of natural populations to spatial environmental variation strongly depend on the relative strength of environmental differences/natural selection and dispersal/gene flow. In absence of geographic barriers, as often is the case in lake ecosystems, gene flow is expected to constrain adaptive divergence between environments – favoring phenotypic plasticity or high trait variability. However, if divergent natural selection is sufficiently strong, adaptive divergence can occur in face of gene flow. The extent of divergence is most often studied between two contrasting environments, whereas potential for multimodal divergence is little explored. We investigated phenotypic (body size, defensive structures, and feeding morphology) and genetic (microsatellites) structure in threespine stickleback (Gasterosteus aculeatus) across five habitat types and two basins (North and South) within the geologically young and highly heterogeneousLakeMývatn, North EastIceland. We found that (1) North basin stickleback were, on average, larger and had relatively longer spines than South basin stickleback, whereas (2) feeding morphology (gill raker number and gill raker gap width) differed among three of five habitat types, and (3) there was only subtle genetic differentiation across the lake. Overall, our results indicate predator and prey mediated phenotypic divergence across multiple habitats in the lake, in face of gene flow.
High‐Accuracy Extraction of Respiratory Sinus Arrhythmia with Statistical Processing Using Normal Distribution
Authors: Numata Takashi , Ogawa Yutaro , Yoshida Lui , Kotani Kiyoshi , Jimbo Yasuhiko 
Published: August 2013

SUMMARYThe autonomic nervous system is important in maintaining homeostasis by mediating the opposing effects of sympathetic and parasympathetic nervous activity on organs. Although it is known that the amplitude of RSA (respiratory sinus arrhythmia) is an index of parasympathetic nervous activity, it is difficult to estimate that activity in real time in everyday situations. This is in part because of body motion and extrasystole. Further, automatic recognition of the R wave on an electrocardiogram is required for a real‐time analysis of the RSA amplitude, and there is an unresolved problem of false recognition of the R wave. In this paper we propose a method of evaluating the amplitude of RSA accurately by statistical processing with probabilistic models. We then estimate parasympathetic nervous activity during body motion and isometric exercise to examine the validity of the method. As a result, using the proposed method we demonstrate that the amplitude of RSA can be extracted in the presence of false recognition of the R wave. An appropriate threshold for the estimate is 1 or 5% because the waveforms of the RSA amplitude do not follow the abrupt changes of parasympathetic nervous activity induced by isometric exercise with the threshold at 10%. Furthermore, the method using the normal distribution is found to be more appropriate than that of the chi‐square distribution for statistical processing. Therefore, we expect that the proposed method can be used to evaluate parasympathetic nervous activity with high accuracy in everyday situations. © 2013 Wiley Periodicals, Inc. Electron Comm Jpn, 96(9): 23–32, 2013; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.11441
A Supporting System for Cloud Service Integration Based on User Profiles
Authors: Okabe Tatsuya , Matsumoto Keinosuke , Mori Naoki 
Published: August 2013

SUMMARYWhile abundant information can be referenced in the Internet Cloud, it is becoming difficult for users to acquire desired information pertinently. Therefore, it is necessary to support users unfamiliar with IT in order to offer information suitable for the user's preferences. This research proposes a service integration supporting system equipped with a recommendation function based on the user's preferences. The research regards bookmarks in a Web browser and tags given to Web services as information showing the user's preference, and a user profile is created using them. A service integration model is built and the proposed system recommends some appropriate examples of integrated services. Compared with conventional supporting systems, the proposed system requires less work for the creation or execution of service integration. © 2013 Wiley Periodicals, Inc. Electron Comm Jpn, 96(9): 14–22, 2013; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.11444
A Denoising Method for Detecting Reflected Waves from Buried Objects by Ground‐Penetrating Radar
Authors: Kobayashi Makoto , Nakano Kazushi 
Published: August 2013

SUMMARYGround‐penetrating radar is a tool for imaging the subsurface with radar pulses. Since a variety of media including buried objects give different dielectric constants, the positions of the buried objects can be detected on the basis of variations in the reflected return signals. This paper presents a denoising method based on the 2D Gabor wavelet transform method to solve pending problems in extracting the signals reflected from buried objects. The validity of our method is demonstrated by comparing it with the f‐k filtering method. © 2013 Wiley Periodicals, Inc. Electron Comm Jpn, 96(9): 1–13, 2013; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.11517
Small Molecules – Big Influence!
Authors: Hindson Karen J. 
Published: August 2013

AbstractEurJIC presents you with a superb double issue on a huge variety of topics that cluster around the central topic of small‐molecule activation. Guest Editors Karsten Meyer and Connie Lu were excellent hands‐on Guest Editors from the start and have compiled an issue with a mix of authors from the well‐established pioneers of the field as well as young investigators.
EurJIC presents you with a superb double issue on a huge variety of topics that cluster around the central topic of small‐molecule activation. Guest Editors Karsten Meyer and Connie Lu were excellent hands‐on Guest Editors from the start and have compiled an issue with a mix of authors from the well‐established pioneers of the field as well as young investigators.