bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jeremian Scriptures in Exile
Authors: Goff Matthew 
Published: July 2024

Abstract
This chapter focuses on the book of Baruch and the Letter of Jeremiah. While very different texts, the history of the two books is intertwined; the Letter of Jeremiah has often been treated as the final chapter of Baruch. The figures of Baruch and Jeremiah are also related. In the Hebrew Bible, Baruch is the scribe of the prophet Jeremiah. The book of Baruch offers a plaintive account of the exiles in Babylon confessing their sins and renewing their commitment to follow the Torah. The book imagines a restored relationship between God and Israel by recounting the exiles returning to Jerusalem. The Letter of Jeremiah is presented as a letter written by Jeremiah to the exiles. Its overarching message is that the gods of the Babylonians are nothing but idols.
Judaism Offers the Best Path to Reason
Authors: Goff Matthew 
Published: July 2024

Abstract
This chapter offers an overview of 4 Maccabees which was considered a scriptural text by early Christians but is not in the canon of any faith community today. The composition seeks to demonstrate the supremacy of reason over the emotions and that Jewish tradition offers the best way to cultivate reason. The composition does so with an extensive retelling of the gruesome story of the death and torture of Eleazar, a mother, and her seven sons, found in 2 Maccabees 6–7. 4 Maccabees draws extensively on Greek philosophy, in particular the Stoic tradition, to present enduring torture and accepting death as the pinnacle of reason.
AUDIT C compared to PEth in middle-aged volunteers
Authors: Fredriksson Marie , Werner Mårten 
Published: July 2024

Abstract

Aims
To compare Alcohol Use Disorders Identification Test (AUDIT C) to phosphatidylethanol (PEth) in middle-aged randomly selected volunteers. Apply previously suggested lower cut-offs for PEth using moderate alcohol intake according to AUDIT C as a reference.

Methods
Within the Swedish CardioPulmonary BioImage Study, 2255 middle-aged (50–64 years of age) volunteers in northern Sweden participated in comparing AUDIT C to PEth 16:0/18:1.

Results
There was a moderate correlation between PEth 16:0/18:1 and AUDIT C (r = 0.66). None of the participants with the AUDIT C-score 0 had a measurable PEth. Of moderate alcohol consumers, according to AUDIT C (AUDIT C 1–3 women, 1–4 men), 96% had a PEth below 0.3 μmol/L, 91% had a PEth below 0.16 μmol/L, and 84% had a PEth below 0.11 μmol/L. With PEth equivalent to excessive alcohol consumption (≥0.3 μmol/L), 26% had an AUDIT C-score below excessive alcohol consumption (&lt;4 for women and &lt;5 for men). Thirty percent of patients with a PEth ≥0.16 μmol/L had an AUDIT C-score below excessive alcohol consumption, and 37% had a PEth ≥0.11 μmol/L. We found no significant correlation between BMI and PEth or AUDIT C.

Conclusions
There is a significant correlation between AUDIT C and PEth. Using AUDIT C alone, 26% of high-consumers, according to PEth, are not found in our cohort, but an AUDIT C-score of 0 will exclude high consumption, according to PEth. Our findings support the current cut-off for PEth of 0.3 μmol/L, but a lower cut-off seems reasonable.
2023 ESBRA Nordmann Award Lecture: Involvement of the gut microbiome-brain axis in alcohol use disorder
Authors: Leclercq Sophie 
Published: July 2024

Abstract
The human intestine is colonized by a variety of microorganisms that influence the immune system, the metabolic response, and the nervous system, with consequences for brain function and behavior. Unbalance in this microbial ecosystem has been shown to be associated with psychiatric disorders, and altered gut microbiome composition related to bacteria, viruses, and fungi has been well established in patients with alcohol use disorder. This review describes the gut microbiome–brain communication pathways, including the ones related to the vagus nerve, the inflammatory cytokines, and the gut-derived metabolites. Finally, the potential benefits of microbiota-based therapies for the management of alcohol use disorder, such as probiotics, prebiotics, and fecal microbiota transplantation, are also discussed.
Evaluation of the Impact of Physical Therapy on Patients With Macromastia Seeking Breast Reduction Surgery
Authors: McCranie Alec , Lee Anna D , Cyrus Chanise , Desjardins Haley , Winocour Julian , Mathes David , Kaoutzanis Christodoulos 
Published: July 2024

Abstract

Background
Macromastia significantly impairs females’ quality of life, with treatments such as physical therapy (PT) often providing only temporary relief. Insurance routinely denies breast reduction surgery, despite little relief after conservative treatments. Research on the efficacy of PT for macromastia is limited.

Objectives
In this study, we investigated the efficacy of PT for macromastia and identified patient factors associated with progression to surgery.

Methods
We conducted a retrospective cohort study of patients with macromastia between 2017 and 2021. We collected data on presenting symptoms, attempted conservative treatments, PT duration, and whether surgery was performed. All patients were invited to participate in a survey regarding their symptoms, treatments, and responses to treatments. Symptoms associated with patients progressing to a breast reduction were evaluated with a multiple logistic regression.

Results
Among the 327 patients identified with macromastia, 312 (95.41%) reported back pain and 272 (83.18%) attempted PT. Of the 72 (22.02%) patients who responded to the survey, 152 (46.48%) underwent subsequent surgery. The mean time from initial consultation to surgery was 283 days. Bra strap grooving was associated with progression to surgery (odds ratio = 1.90, CI = 1.02-3.54). Mean patient-reported pain levels decreased after surgery compared to after PT (pre-PT = 7.1, post-PT = 7.1, post-surgery = 3.1, P &lt; .001).

Conclusions
Patients frequently undergo PT before breast reduction surgery despite no significant reduction in pain, whereas those who undergo surgery experience permanent relief and significantly reduced pain. Patients with bra strap grooving are more likely to progress to surgery. The requirement for PT as a prerequisite for surgery by insurance companies should be reevaluated.

Level of Evidence: 3
The functional connectivity between right insula and anterior cingulate cortex underlying the association between future self-continuity and delay discounting
Authors: Zhao Hengyue , Sun Jingjing , Zhang Rong , Jiang Yumeng , Zhang Yuetong , Feng Tingyong , Feng Pan 
Published: July 2024

Abstract
Delay discounting refers to the tendency of individuals to devalue future rewards as the delay in their receipt increases over time. Previous studies have indicated that future self-continuity correlates with delay discounting rates. However, the neural basis underlying the relationship between future self-continuity and delay discounting is not clear. To address this question, we used voxel-based morphometry and resting-state functional connectivity analyses to investigate the neural basis underlying the association between future self-continuity and delay discounting. Behavioral result showed that future self-continuity was positively associated with delay discounting. Voxel-based morphometry analysis result indicated that gray matter volume in the right dorsal anterior insula was positively correlated with future self-continuity. Resting-state functional connectivity analysis found that functional connectivity between the right dorsal anterior insula and anterior cingulate cortex was positively associated with future self-continuity. Mediation analysis showed that the right dorsal anterior insula–right anterior cingulate cortex functional connectivity partially mediated the relationship between future self-continuity and delay discounting. These results suggested that right dorsal anterior insula–right anterior cingulate cortex functional connectivity could be the neural basis underlying the association between future self-continuity and delay discounting. In summary, the study provided novel insights into how future self-continuity affected delay discounting and offers new explanations from a neural perspective.
Aggregation of positively charged poly(methyl methacrylate) latex particles in the presence of trifluoromethanesulfonate anion
Authors: Yamazaki Takashi , Tsuji Toshikazu 
Published: July 2024

Abstract
We investigated the unique aggregation behavior of 3 types of positively charged poly(methyl methacrylate) (PMMA) latex particles in the presence of a trifluoromethanesulfonate (triflate) anion. The particles were prepared based on surfactant-free emulsion polymerization using azo radical initiators. The triflate anion was strongly adsorbed to surfaces of positively charged PMMA latex particles, as confirmed by electrophoresis. Additionally, its presence significantly reduced the critical coagulation concentration of the cationic PMMA latex particles compared with other anions.
Synthesis of Pd–Pt–P amorphous nanoparticles
Authors: Ikeda Kenta , Mukoyoshi Megumi , Kusada Kohei , Yamamoto Tomokazu , Murakami Yasukazu , Kitagawa Hiroshi 
Published: July 2024

Abstract
Amorphous materials are very attractive materials because of their unique properties, including high corrosion resistance and catalytic activity. Creating such materials on a nanoscale is very effective in maximizing their performance. However, it is difficult to synthesize amorphous nanomaterials by conventional rapid cooling methods, commonly used for bulk amorphous materials. Therefore, there are not as many reports about amorphous nanomaterials as bulk materials. Herein we report the first synthesis of Pd–Pt–P amorphous nanoparticles by a 2-step synthesis method. They were also characterized.
Preliminary Findings From the Dynamics of the Immune Responses to Repeat Influenza Vaccination Exposures (DRIVE I) Study: A Randomized Controlled Trial
Authors: Cowling Benjamin J , Wong Sook-San , Santos Jefferson J S , Touyon Lisa , Ort Jordan T , Ye Naiqing , Kwok Natalie K M , Ho Faith , Cheng Samuel M S , Ip Dennis K M , Peiris Malik , Webby Richard J , Wilson Patrick C , Valkenburg Sophie A , Tsang John S , Leung Nancy H L , Hensley Scott E , Cobey Sarah 
Published: July 2024

Abstract

Background
Studies have reported that repeated annual vaccination may influence influenza vaccination effectiveness in the current season.

Methods
We established a 5-year randomized placebo-controlled trial of repeated influenza vaccination (Flublok; Sanofi Pasteur) in adults 18–45 years of age. In the first 2 years, participants were randomized to receive vaccine or saline placebo as follows: placebo-placebo (P-P), placebo-vaccine (P-V), or vaccine-vaccine (V-V). Serum samples were collected each year just before vaccination and after 30 and 182 days. A subset of serum samples collected at 5 time points from 95 participants were tested for antibodies against vaccine strains.

Results
From 23 October 2020 through 11 March 2021 we enrolled and randomized 447 adults. Among vaccinated individuals, antibody titers increased between days 0 and 30 against each of the vaccine strains, with smaller increases for repeat vaccinees who on average had higher prevaccination titers in year 2. There were statistically significant differences in the proportions of participants achieving ≥4-fold rises in antibody titer for the repeat vaccinees for influenza A(H1N1), B/Victoria, and B/Yamagata, but not for A(H3N2). Among participants who received vaccination in year 2, there were no significant differences between the P-V and V-V groups in geometric mean titers at day 30 or the proportions of participants with antibody titers ≥40 at day 30 for any of the vaccine strains.

Conclusions
In the first 2 years, during which influenza did not circulate, repeat and first-time vaccinees had similar postvaccination geometric mean titers to all 4 vaccine strains, indicative of similar levels of clinical protection.
Clinical Trials Registration. NCT04576377
Validating Combination Throat-Nasal Swab Specimens for Coronavirus Disease 2019 Tests Would Improve Early Detection, Especially for the Most Vulnerable
Authors: Viloria Winnett Alexander , Stenzel Timothy , Ismagilov Rustem F 
Published: July 2024

Abstract
Early detection of severe acute respiratory syndrome coronavirus 2 infection by diagnostic tests can prompt actions to reduce transmission and improve treatment efficacy, especially for vulnerable groups such as immunocompromised individuals. Recent evidence suggests that sampling the throat in addition to the nose improves clinical sensitivity during early infection for both antigen and molecular coronavirus disease 2019 tests. We urge test manufacturers to validate tests for use with throat swab, in combination with nasal swabs.
Long-term outcomes of high bleeding risk patients undergoing percutaneous coronary intervention: a Korean nationwide registry
Authors: Kang Jeehoon , Yun Junpil , Park Kyung Woo , Park Minae , Park Sojeong , Hwang Doyeon , Han Jung-Kyu , Yang Han-Mo , Kang Hyun-Jae , Koo Bon-Kwon , Angiolillo Dominick J , Urban Philip , Kim Hyo-Soo 
Published: July 2024

Abstract

Background and Aims
Patients with high bleeding risk (HBR) undergoing percutaneous coronary intervention (PCI) are at increased risk of not only bleeding, but also ischaemic events. This study aimed to determine the long-term relative risk of ischaemic and bleeding events in HBR patients.

Methods
This study was a nationwide cohort study, based on the Korean National Health Insurance Review and Assessment Service database. Patients diagnosed with stable angina or acute coronary syndrome and those who underwent PCI in Korea between 2009 and 2018 were included in the analysis. According to the Academic Research Consortium HBR criteria, the total population was divided into HBR and non-HBR groups. The co-primary outcomes were major bleeding events and ischaemic (composite of cardiac death, myocardial infarction, and ischaemic stroke) events.

Results
Among a total of 325 417 patients who underwent PCI, 66 426 patients (20.4%) had HBR. During the follow-up period, HBR patients had a higher risk for major bleeding events (23.9% vs. 8.9%, P &lt; .001) and ischaemic events (33.8% vs. 14.4%, P &lt; .001). However, the impact of HBR was significant for major bleeding events [hazard ratio (HR) 3.12, 95% confidence interval (CI) 3.04–3.21, P &lt; .001] and for ischaemic events (HR 2.50, 95% CI 2.45–2.56, P &lt; .001). The HBR group was also associated with a greater risk of all-cause mortality (HR 3.73, 95% CI 3.66–3.79, P &lt; .001). The average annual rate of major bleeding events within the first year after PCI was 5.5% for a single major criterion, and 2.9% for a single minor criterion.

Conclusions
Among patients undergoing PCI, those with HBR were at increased long-term risk for both bleeding and ischaemic events, with a greater risk of mortality compared to non-HBR patients.
Variation and Interaction of Distinct Subgenomes Contribute to Growth Diversity in Intergeneric Hybrid Fish
Authors: Ren Li , Luo Mengxue , Cui Jialin , Gao Xin , Zhang Hong , Wu Ping , Wei Zehong , Tai Yakui , Li Mengdan , Luo Kaikun , Liu Shaojun 
Published: July 2024

Abstract
Intergeneric hybridization greatly reshapes regulatory interactions among allelic and non-allelic genes. However, their effects on growth diversity remain poorly understood in animals. In this study, we conducted whole-genome sequencing and RNA sequencing analyses in diverse hybrid varieties resulting from the intergeneric hybridization of goldfish (Carassius auratus red var.) and common carp (Cyprinus carpio). These hybrid individuals were characterized by distinct mitochondrial genomes and copy number variations. Through a weighted gene correlation network analysis, we identified 3693 genes as candidate growth-regulating genes. Among them, the expression of 3672 genes in subgenome R (originating from goldfish) displayed negative correlations with body weight, whereas 20 genes in subgenome C (originating from common carp) exhibited positive correlations. Notably, we observed intriguing expression patterns of solute carrier family 2 member 12 (slc2a12) in subgenome C, showing opposite correlations with body weight that changed with water temperatures, suggesting differential interactions between feeding activity and weight gain in response to seasonal changes for hybrid animals. In 40.30% of alleles, we observed dominant trans-regulatory effects in the regulatory interactions between distinct alleles from subgenomes R and C. Integrating analyses of allele-specific expression and DNA methylation data revealed that DNA methylation on both subgenomes shaped the relative contribution of allelic expression to the growth rate. These findings provide novel insights into the interactions of distinct subgenomes that underlie heterosis in growth traits and contribute to a better understanding of multiple allelic traits in animals.
Mutation of YFT3, an isomerase in the isoprenoid biosynthetic pathway, impairs its catalytic activity and carotenoid accumulation in tomato fruit
Authors: Li Wenzhen , Chen Lulu , Zhao Weihua , Li Yuhang , Chen Ying , Wen Tengjian , Liu Zhengjun , Huang Chao , Zhang Lida , Zhao Lingxia 
Published: July 2024

Abstract
Tomato fruit colors are directly associated with their appearance quality and nutritional value. However, tomato fruit color formation is an intricate biological process that remains elusive. In this work we characterized a tomato yellow fruited tomato 3 (yft3, e9292, Solanum lycopersicum) mutant with yellow fruits. By the map-based cloning approach, we identified a transversion mutation (A2117C) in the YFT3 gene encoding a putative isopentenyl diphosphate isomerase (SlIDI1) enzyme, which may function in the isoprenoid biosynthetic pathway by catalyzing conversion between isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). The mutated YFT3 (A2117C) (designated YFT3 allele) and the YFT3 genes did not show expression difference at protein level, and their encoded YFT3 allelic (S126R) and YFT3 proteins were both localized in plastids. However, the transcript levels of eight genes (DXR, DXS, HDR, PSY1, CRTISO, CYCB, CYP97A, and NCED) associated with carotenoid synthesis were upregulated in fruits of both yft3 and YFT3 knockout (YFT3-KO) lines at 35 and 47 days post-anthesis compared with the red-fruit tomato cultivar (M82). In vitro and in vivo biochemical analyses indicated that YFT3 (S126R) possessed much lower enzymatic activities than the YFT3 protein, indicating that the S126R mutation can impair YFT3 activity. Molecular docking analysis showed that the YFT3 allele has higher ability to recruit isopentenyl pyrophosphate (IPP), but abolishes attachment of the Mg2+ cofactor to IPP, suggesting that Ser126 is a critical residue for YTF3 biochemical and physiological functions. As a result, the yft3 mutant tomato line has low carotenoid accumulation and abnormal chromoplast development, which results in yellow ripe fruits. This study provides new insights into molecular mechanisms of tomato fruit color formation and development.
Local and systemic transcriptome and spliceome reprogramming induced by the root-knot nematode Meloidogyne incognita in tomato
Authors: Ozdemir Selin , Piya Sarbottam , Lopes-Caitar Valeria S , Coffey Nicole , Rice J Hollis , Hewezi Tarek 
Published: July 2024

Abstract
Root-knot nematodes (Meloidogyne spp.) are widely spread root parasites that infect thousands of vascular plant species. These highly polyphagous nematodes engage in sophisticated interactions with host plants that results in the formation of knot-like structures known as galls whose ontogeny remains largely unknown. Here, we determined transcriptome changes and alternative splicing variants induced by Megalaima incognita in galls and neighboring root cells at two distinct infective stages. M. incognita induced substantial transcriptome changes in tomato roots both locally in galls and systemically in neighboring cells. A considerable parallel regulation of gene expression in galls and neighboring cells were detected, indicative of effective intercellular communications exemplified by suppression of basal defense responses particularly during the early stage of infection. The transcriptome analysis also revealed that M. incognita exerts a tight control over the cell cycle process as a whole that results in an increase of ploidy levels in the feeding sites and accelerated mitotic activity of the gall cells. Alternative splicing analysis indicated that M. incognita significantly modulates pre-mRNA splicing as a total of 9064 differentially spliced events from 2898 genes were identified where intron retention and exon skipping events were largely suppressed. Furthermore, a number of differentially spliced events were functionally validated using transgenic hairy root system and found to impact gall formation and nematode egg mass production. Together, our data provide unprecedented insights into the transcriptome and spliceome reprogramming induced by M. incognita in tomato with respect to gall ontogeny and nematode parasitism.
A question-answering framework for automated abstract screening using large language models
Authors: Akinseloyin Opeoluwa , Jiang Xiaorui , Palade Vasile 
Published: July 2024

Abstract

Objective
This paper aims to address the challenges in abstract screening within systematic reviews (SR) by leveraging the zero-shot capabilities of large language models (LLMs).

Methods
We employ LLM to prioritize candidate studies by aligning abstracts with the selection criteria outlined in an SR protocol. Abstract screening was transformed into a novel question-answering (QA) framework, treating each selection criterion as a question addressed by LLM. The framework involves breaking down the selection criteria into multiple questions, properly prompting LLM to answer each question, scoring and re-ranking each answer, and combining the responses to make nuanced inclusion or exclusion decisions.

Results and Discussion
Large-scale validation was performed on the benchmark of CLEF eHealth 2019 Task 2: Technology-Assisted Reviews in Empirical Medicine. Focusing on GPT-3.5 as a case study, the proposed QA framework consistently exhibited a clear advantage over traditional information retrieval approaches and bespoke BERT-family models that were fine-tuned for prioritizing candidate studies (ie, from the BERT to PubMedBERT) across 31 datasets of 4 categories of SRs, underscoring their high potential in facilitating abstract screening. The experiments also showcased the viability of using selection criteria as a query for reference prioritization. The experiments also showcased the viability of the framework using different LLMs.

Conclusion
Investigation justified the indispensable value of leveraging selection criteria to improve the performance of automated abstract screening. LLMs demonstrated proficiency in prioritizing candidate studies for abstract screening using the proposed QA framework. Significant performance improvements were obtained by re-ranking answers using the semantic alignment between abstracts and selection criteria. This further highlighted the pertinence of utilizing selection criteria to enhance abstract screening.