bluuebunny/crossref_metadata_2025_split huggingface dataset:
The biological effects of higher and lower positive end-expiratory pressure in pulmonary and extrapulmonary acute lung injury with intra-abdominal hypertension
Authors: Santos Cíntia Lourenco , Moraes Lillian , Santos Raquel Souza , dos Santos Samary Cynthia , Silva Johnatas Dutra , Morales Marcelo Marcos , Capelozzi Vera Lucia , de Abreu Marcelo Gama , Schanaider Alberto , Silva Pedro Leme , Garcia CristianeSousaNascimento Baez , Pelosi Paolo , Rocco PatriciaRieken Macedo 
Published: June 2014

Abstract
Introduction
Mechanical ventilation with high positive end-expiratory pressure (PEEP) has been used in patients with acute respiratory distress syndrome (ARDS) and intra-abdominal hypertension (IAH), but the role of PEEP in minimizing lung injury remains controversial. We hypothesized that in the presence of acute lung injury (ALI) with IAH: 1) higher PEEP levels improve pulmonary morphofunction and minimize lung injury; and 2) the biological effects of higher PEEP are more effective in extrapulmonary (exp) than pulmonary (p) ALI.

Methods
In 48 adult male Wistar rats, ALIp and ALIexp were induced by Escherichia coli lipopolysaccharide intratracheally and intraperitoneally, respectively. After 24 hours, animals were anesthetized and mechanically ventilated (tidal volume of 6 mL/kg). IAH (15 mmHg) was induced and rats randomly assigned to PEEP of 5 (PEEP5), 7 (PEEP7) or 10 (PEEP10) cmH2O for 1 hour.

Results
In both ALIp and ALIexp, higher PEEP levels improved oxygenation. PEEP10 increased alveolar hyperinflation and epithelial cell damage compared to PEEP5, independent of ALI etiology. In ALIp, PEEP7 and PEEP10 increased lung elastance compared to PEEP5 (4.3 ± 0.7 and 4.3 ± 0.9 versus 3.1 ± 0.3 cmH2O/mL, respectively, P <0.01), without changes in alveolar collapse, interleukin-6, caspase-3, type III procollagen, receptor for advanced glycation end-products, and vascular cell adhesion molecule-1 expressions. Moreover, PEEP10 increased diaphragmatic injury compared to PEEP5. In ALIexp, PEEP7 decreased lung elastance and alveolar collapse compared to PEEP5 (2.3 ± 0.5 versus 3.6 ± 0.7 cmH2O/mL, P <0.02, and 27.2 (24.7 to 36.8) versus 44.2 (39.7 to 56.9)%, P <0.05, respectively), while PEEP7 and PEEP10 increased interleukin-6 and type III procollagen expressions, as well as type II epithelial cell damage compared to PEEP5.

Conclusions
In the current models of ALI with IAH, in contrast to our primary hypothesis, higher PEEP is more effective in ALIp than ALIexp as demonstrated by the activation of biological markers. Therefore, higher PEEP should be used cautiously in the presence of IAH and ALI, mainly in ALIexp.
Continuous glucose control in the ICU: report of a 2013 round table meeting
Authors: Wernerman Jan , Desaive Thomas , Finfer Simon , Foubert Luc , Furnary Anthony , Holzinger Ulrike , Hovorka Roman , Joseph Jeffrey , Kosiborod Mikhail , Krinsley James , Mesotten Dieter , Nasraway Stanley , Rooyackers Olav , Schultz Marcus J , Van Herpe Tom , Vigersky Robert A , Preiser Jean-Charles 
Published: June 2014

AbstractAchieving adequate glucose control in critically ill patients is a complex but important part of optimal patient management. Until relatively recently, intermittent measurements of blood glucose have been the only means of monitoring blood glucose levels. With growing interest in the possible beneficial effects of continuous over intermittent monitoring and the development of several continuous glucose monitoring (CGM) systems, a round table conference was convened to discuss and, where possible, reach consensus on the various aspects related to glucose monitoring and management using these systems. In this report, we discuss the advantages and limitations of the different types of devices available, the potential advantages of continuous over intermittent testing, the relative importance of trend and point accuracy, the standards necessary for reporting results in clinical trials and for recognition by official bodies, and the changes that may be needed in current glucose management protocols as a result of a move towards increased use of CGM. We close with a list of the research priorities in this field, which will be necessary if CGM is to become a routine part of daily practice in the management of critically ill patients.
Biodegradation of high concentrations of halomethanes by a fermentative enrichment culture
Authors: Shan Huifeng , Wang Han , Yu Rong , Jacob Priya , Freedman David L 
Published: June 2014

Abstract
A fermentative enrichment culture (designated DHM-1) that grows on corn syrup was evaluated for its ability to cometabolically biodegrade high concentrations of chloroform (CF), carbon tetrachloride (CT), and trichlorofluoromethane (CFC-11). When provided with corn syrup and vitamin B12 (0.03 mol B12 per mol CF), DHM-1 grew and biodegraded up to 2,000 mg/L of CF in 180 days, with only minor transient accumulation of dichloromethane and chloromethane. CT (15 mg/L) and CFC-11 (25 mg/L) were also biodegraded without significant accumulation of halomethane daughter products. The rate of CF biodegradation followed a Michaelis-Menten-like pattern with respect to the B12 concentration; one-half the maximum rate (66 mg CF/L/d) occurred at 0.005 mol B12 per mol CF. DHM-1 was able to biodegrade 500 mg/L of CF at an inoculum level as low as 10−8 mg protein/L. The highest rate of CF biodegradation occurred at pH 7.7; activity decreased substantially below pH 6.0. DHM-1 biodegraded mixtures of CT, CFC-11, and CF, although CFC-11 inhibited CF biodegradation. Evidence for compete defluorination of CFC-11 was obtained based on a fluoride mass balance. Overall, the results suggest that DHM-1 may be effective for bioaugmentation in source zones contaminated with thousands of milligrams per liter of CF and tens of milligrams per liter of CT and CFC-11.
Activation of the Dopamine Receptor Type-2 (DRD2) Promoter by 9-Cis Retinoic Acid in a Cellular Model of Cushing's Disease Mediates the Inhibition of Cell Proliferation and ACTH Secretion Without a Complete Corticotroph-to-Melanotroph Transdifferentiation
Authors: Occhi Gianluca , Regazzo Daniela , Albiger Nora Maria , Ceccato Filippo , Ferasin Sergio , Scanarini Massimo , Denaro Luca , Cosma Chiara , Plebani Mario , Cassarino Maria Francesca , Mantovani Giovanna , Stalla Günter K. , Pecori Giraldi Francesca , Paez-Pareda Marcelo , Scaroni Carla 
Published: June 2014

AbstractCushing's disease (CD) is a rare condition in which hypercortisolemia is secondary to excessive ACTH release from a pituitary corticotroph adenoma. CD is associated with significant morbidity and mortality, and a safe therapy that effectively targets the pituitary tumor is still lacking. Retinoic acid (RA) and dopamine agonists (DAs) have recently been considered as monotherapy in CD patients, and satisfactory results have been reported, albeit in a limited number of patients. Given the permissive role of RA on the dopamine receptor type-2 (DRD2), the aim of the present study was to see whether a combination of 9-cis RA and the DA bromocriptine (Br) might represent a possible treatment for CD. Here we show that 9-cis RA induces a functional DRD2 in the pituitary corticotroph cell line AtT20, and increases cell sensitivity to Br via a mechanism only partially related to corticotroph-to-melanotroph transdifferentiation. In addition, 9-cis RA and Br act synergistically to modulate cell viability, with favorable implications for clinical use. In nearly 45% of corticotropinoma-derived primary cultures, the combined administration of 9-cis RA and Br lowered the steady-state level of the ACTH precursor proopiomelanocortin (POMC) more efficiently than either of the drugs alone. In conclusion, the effects of a combination of 9-cis RA and Br on ACTH synthesis/secretion and cell viability in AtT20, and on POMC transcriptional activity in human corticotropinomas might represent a suitable starting point for assessing the potential of this treatment regimen for ACTH-secreting pituitary adenomas. This study thus has potentially important implications for novel therapeutic approaches to CD.
The Prostate Cancer TMPRSS2:ERG Fusion Synergizes With the Vitamin D Receptor (VDR) to Induce CYP24A1 Expression-Limiting VDR Signaling
Authors: Kim Jung-Sun , Roberts Justin M. , Bingman William E. , Shao Longjiang , Wang Jianghua , Ittmann Michael M. , Weigel Nancy L. 
Published: June 2014

AbstractA number of preclinical studies have shown that the activation of the vitamin D receptor (VDR) reduces prostate cancer (PCa) cell and tumor growth. The majority of human PCas express a transmembrane protease serine 2 (TMPRSS2):erythroblast transformation-specific (ETS) fusion gene, but most preclinical studies have been performed in PCa models lacking TMPRSS2:ETS in part due to the limited availability of model systems expressing endogenous TMPRSS2:ETS. The level of the active metabolite of vitamin D, 1α,25-dihydroxyvitamin D3 (1,25D), is controlled in part by VDR-dependent induction of cytochrome P450, family 24, subfamily 1, polypeptide1 (CYP24A1), which metabolizes 1,25D to an inactive form. Because ETS factors can cooperate with VDR to induce rat CYP24A1, we tested whether TMPRSS2:ETS would cause aberrant induction of human CYP24A1 limiting the activity of VDR. In TMPRSS2:ETS positive VCaP cells, depletion of TMPRSS2:ETS substantially reduced 1,25D-mediated CYP24A1 induction. Artificial expression of the type VI+72 TMPRSS2:ETS isoform in LNCaP cells synergized with 1,25D to greatly increase CYP24A1 expression. Thus, one of the early effects of TMPRSS2:ETS in prostate cells is likely a reduction in intracellular 1,25D, which may lead to increased proliferation. Next, we tested the net effect of VDR action in TMPRSS2:ETS containing PCa tumors in vivo. Unlike previous animal studies performed on PCa tumors lacking TMPRSS2:ETS, EB1089 (seocalcitol) (a less calcemic analog of 1,25D) did not inhibit the growth of TMPRSS2:ETS containing VCaP tumors in vivo, suggesting that the presence of TMPRSS2:ETS may limit the growth inhibitory actions of VDR. Our findings suggest that patients with TMPRSS2:ETS negative tumors may be more responsive to VDR-mediated growth inhibition and that TMPRSS2:ETS status should be considered in future clinical trials.
Characterization of Neural Estrogen Signaling and Neurotrophic Changes in the Accelerated Ovarian Failure Mouse Model of Menopause
Authors: Van Kempen Tracey A. , Gorecka Jolanta , Gonzalez Andreina D. , Soeda Fumio , Milner Teresa A. , Waters Elizabeth M. 
Published: June 2014

AbstractAccelerated ovarian failure (AOF) can be induced in young mice with low doses of 4-vinylcyclohexene diepoxide (VCD), modeling the hormone changes observed across menopause. We assessed markers of synaptic plasticity in the hippocampus, anxiety-like behavior, and spatial learning longitudinally at 4 time points across the AOF model: premenopause, early perimenopause, late perimenopause, and postmenopause (POST). As others have shown, VCD administration decreased ovarian follicle counts and increased acyclicity as the model progressed to POST but with no impact on organ or body weights. The morphology of Iba1 immunoreactive microglia did not differ between vehicle- and VCD-administered mice. Hippocampal postsynaptic density 95 levels were minimally altered across the AOF model but decreased at POST in CA3b 24 hours after exogenous estradiol benzoate (EB). In contrast, hippocampal phosphorylated AKT levels transiently decreased in premenopause but increased at POST after 24 hours of EB in select subregions. Electron microscopy revealed fewer estrogen receptor α containing dendritic spines and terminals in CA1 stratum radiatum at POST. mRNA levels of most brain-derived neurotrophic factor exons (except V and VI) were lower in POST compared with ovariectomized mice. Exon V was sensitive to 24 hours of EB administration in POST-VCD. Anxiety-like behavior was unaffected at any menopause phase. Spatial learning was unaffected in all groups, but POST-VCD mice performed below chance. Our results suggest that the AOF model is suitable for longitudinal studies of neurobiological changes across the menopause transition in mice. Our findings also point to complex interactions between estrogen receptors and pathways involved in synaptic plasticity.
Fiberoptic monitoring of central venous oxygen saturation (PediaSat) in small children undergoing cardiac surgery: continuous is not continuous
Authors: Iodice Francesca G. , Ricci Zaccaria , Haiberger Roberta , Favia Isabella , Cogo Paola 
Published: June 2014

Background: Monitoring of superior vena cava saturation (ScvO2) has become routine in the management of pediatric patients undergoing cardiac surgery. The objective of our study was to evaluate the correlation between continuous ScvO2 by the application of a fiber-optic oximetry catheter (PediaSat) and intermittent ScvO2 by using standard blood gas measurements. These results were compared to those obtained by cerebral near infrared spectroscopy (cNIRS).Setting: Tertiary pediatric cardiac intensive care unit (PCICU).Methods and main results: A retrospective study was conducted in consecutive patients who were monitored with a 4.5 or 5.5 F PediaSat catheter into the right internal jugular vein. An in vivo calibration was performed once the patient was transferred to the PCICU and re-calibration took place every 24 hours thereafter. Each patient had a NIRS placed on the forehead. Saturations were collected every 4 hours until extubation. Ten patients with a median age of 2.2 (0.13-8.5) years and a weight of 12.4 (3.9-24) kg were enrolled. Median sampling time was 32 (19-44) hours: 64 pairs of PediaSat and ScVO2 saturations showed a poor correlation (r=0.62, 95% CI 44-75; p<0.0001) and Bland Altman analysis for repeated measures showed an average difference of 0.34 with a standard deviation of 7,9 and 95% limits of agreement from -15 to 16. Thirty-six pairs of cNIRS and ScVO2 saturations showed a fair correlation (r=0.79, 95% CI 0.60-0.89; p<0.0001) an average difference of -1.4 with a standard deviation of 6 and 95% limits of agreement from -13 to 10. Analysis of median percentage differences between PediaSat and ScvO2 saturation over time revealed that, although not statistically significant, the change in percentage saturation differences was clinically relevant after the 8th hour from calibration (from -100 to +100%).Conclusion: PediaSat catheters showed unreliable performance in our cohort. It should be further investigated whether repeating calibrations every 8 hours may improve the accuracy of this system. CNIRS may provide similar results with a lower invasiveness.
Comparative quality of life of Nigerian caregivers of children with cerebral palsy
Authors: Fatudimu Margaret B , Hamzat Talhatu K , Akinyinka Olusegun O 
Published: June 2014

Background:Information on how caring for children with cerebral palsy (CP) affects Nigerian caregivers' quality of life (QoL) is scarce. The QoL of Nigerian caregivers for children with cerebral palsy (CGCP) was compared with that of their age-matched counterparts with similar socioeconomic backgrounds who were caring for normally developing children, who made up the control group (CG). Motor function of the children with CP was also correlated with the QoL of their caregivers.Methods:Participants in this longitudinal study were 312 people comprising 107 CCP, 107 CGCP and 98 CG. The QoL was assessed at baseline and at the second, fifth and eighth month using the 26–item World Health Organization Quality of Life-Bref (WHOQoL-Bref) questionnaire. Motor function performance of the children with CP was assessed at the same intervals using the Gross Motor Function Measure (GMFM).Findings:Most of the CGCP and CG (82.3% and 93.8% respectively) were mothers of the children. At every point of assessment, the CGCP recorded significantly lower WHOQoL-Bref scores. Significant improvement in the GMFM score of the children with CP was observed during the study. The WHOQoL-Bref scores in CGCP correlated significantly with the GMFM scores of children with CP (P<0.05) at the fifth and eighth month.Conclusion:People caring for children with CP have a lower quality of life than their counterparts caring for normally developing children.
Exploring the health benefits of singing for young people with cystic fibrosis
Authors: Irons J Yoon , Kuipers Kathy , Petocz Peter 
Published: June 2014

Background: Recent evidence suggests that singing may improve health and wellbeing. The health benefits of singing for young people with cystic fibrosis (CF) have not been explored. This study aims to understand the impact of a singing intervention on hospitalised young people with CF. Method: Participants (n=20) completed a self-report satisfaction checklist following eight individual singing sessions during hospitalisation. participants' checklist responses were qualitatively analysed using the International Classification of Functioning, Disability and Health for Children and Youth (ICF-CY). Findings: The study has found that singing has a positive impact on health, particularly with respect to the Body Functions and Activities and Participation components of the ICF-CY. In addition, participants reported a high degree of enjoyment and satisfaction with the singing programme. Conclusions: The findings support the hypothesis that singing can improve physical and psychological aspects of health. The ICF-CY provides a useful framework to gain a better understanding of the singing experience and its perceived health benefits for young people with CF.
Collaborative local governance for arts in health: Learning from an arts programme for hospital-based stroke patients
Authors: Baumann Matt , Peck Simon , Collins Carrie , Johnson Jeannine , Riches Colin , Eades Guy 
Published: June 2014

Abstract
The issue of training, supervision of artists and governance of arts and health practice is a major area requiring resolution for the development of arts-in-health practice. Moss and O’Neill posit that arts and health practice should be regulated and professionalized, whilst Mike White argues that arts practice should be the collective responsibility of local agencies and individuals working together to establish arts and health programmes. There has been limited discussion and debate within and between leading arts and health organizations. This article contributes to and raises the profile of this issue, by describing the development of a substantive arts programme for stroke patients, focusing on how artists were sensitized, prepared and supported to work with stroke patients in the specific setting of an arts programme for hospital-based stroke patients. It suggests that professional artists can be supported locally to deliver valued arts programmes. The article also outlines how the materials developed for the programme could be used in a number of ways to help support the development of flexible, local, professional arts practice in health contexts in other areas.
Reviews
Authors: Landis Heidi , Peacock Karen , Young Jessica , Rae Kym M. 
Published: June 2014

Abstract
Dramatherapy with Myth and Fairytale: The Golden Stories of Sesame, Jenny Pearson, Mary Smail and Pat Watts (2013) London: Jessica Kingsley Publishers, 256 pp., ISBN: 9781849050302, p/bk, £22.99/$36.95
Museums, Health, and Well-Being, Helen Chatterjee and Guy Noble (2013) England: Ashgate Publishing Limited, 146 pp., ISBN: 9781409425816, h/bk, £45.00
Soul and Spirit in Dance Movement Psychotherapy: A Transpersonal Approach, Jill Hayes (2013) London: Jessica Kingsley Publishers, 224 pp., ISBN: 9781849053082, p/bk, US $24.75, eISBN: 9780857006493, e-book, US $19.49
Breathing Deeply: Culture of Health and Well-being Conference, Bristol, 24–27 June 2013
‘Sound of Well-being’ revisited – Choir singing and well-being among Norwegian municipal employees
Authors: Vaag Jonas , Saksvik Per Øystein , Milch Vibeke , Theorell Töres , Bjerkeset Ottar 
Published: June 2014

Abstract
A recent cross-sectional study investigating an organizational choir-singing intervention called ‘Sound of Well-being’ (SOW) indicated health and organizational benefits, and a gender-specific pattern of participation and outcomes. In this study we investigate participation and effects in a short version of SOW. A total of 1100 employees of a Norwegian municipality were invited to participate in SOW. At baseline, 472 (42.9 per cent) employees filled in a questionnaire concerning demographics, personality, health, engagement, commitment and psychosocial work environment. A total of 312 (66.1 per cent) of these completed the same survey one to three weeks after SOW was finished. We found that female gender and extroversion were linked to participation in SOW. Women reported significant changes in engagement, self-perceived health and control, while men reported changes in job demands. Overall, participants reported an increase, while non-participants reported decrease on aforementioned variables. In terms of participation and effects of SOW, findings differed between professions, personality types and gender. In order to provide desirable alternatives to a wider group of employees, future interventions should include a variety of both receptive and creative activities.
Visual narratives performing and transforming people living with autoimmune illness: A pilot case study
Authors: Grushka Kathryn , Squance Marline L. , Reeves Glenn E. M. 
Published: June 2014

Abstract
Identity perspectives underpin an arts health intervention research project titled ‘Artmaking, visual narrative and wellbeing’. This article considers the adaptability benefits of working with art-making narratives to support the long-term emotional and physical well-being of people living with chronic autoimmune illness. The article describes the methods and background to the pilot transdisciplinary case study of twelve participants, the intervention, data sources and qualitative strategies that were intersected with quantitative, medical, physical and functionality indicators. It identified that time and memory work, using montage methods in visual narratives, supported a renewed confidence in the participants’ life journey. Notions of pain and time temporarily retreated when strong affective responses emerged from new storied possibilities. These findings demonstrate how visual narrative methods work as a sense-making experience for the collision between past narratives and present specific medical and/or sociocultural contexts. The findings are discussed in the context of their potential contribution to the wider arts and health debate.
James Brooke, Rajah von Sarawak. Vom „Charakter“ und der Konstruktion eines viktorianischen Kolonialhelden
Authors: Stuchtey Benedikt 
Published: June 2014

Zusammenfassung
James Brooke (1803–1868), Sohn eines Beamten der East India Company und Gründer der Dynastie der sogenannten „White Rajahs of Sarawak“, besuchte die Region von Sarawak auf Borneo zum ersten Mal 1838 und war zwei Jahre später daran beteiligt, hier eine Rebellion niederzuschlagen. Als Dank und Belohnung übertrug ihm der Sultan von Brunei die Kontrolle über Sarawak als „Rajah“, und nach Bestätigung durch das britische Parlament wurde diese Position durch Brookes Neffen und Erben, Charles Brooke (1829–1917), verstetigt. James Brooke modernisierte die Verwaltung, führte ein einfacheres Steuersystem ein und bekämpfte das Piratentum. Als eine Kommission auf Singapur einberufen wurde, um Vorwürfe zu prüfen, Brooke habe Einheimische misshandelt, wurde er freigesprochen und in seinem Amt als britischer Generalkonsul bestätigt. Auch die britische Öffentlichkeit, der er sich nur während eines Kurzbesuches nach England 1847 stellte, war ambivalent: zwischen Bewunderung für einen Kolonialhelden einerseits und scharfer Kritik an seiner willkürlichen Kolonialherrschaft jenseits der offiziellen britischen Interessen andererseits. Der „Charakter“, ein viktorianisches Schlüsselwort, stand zur Diskussion, ebenso die Frage, in welchen Kategorien die Expansion zu erfassen sei. So ist Brooke ein gutes Beispiel für die „Hilflosigkeit“ und das „Unvollendete“ des britischen Empires im 19. Jahrhundert.