bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors associated with radiographic progression and neurologic decline in patients with isolated traumatic subarachnoid hemorrhage
Authors: Ravipati Kaushik , Khan Inamullah , Chen Wesley , Nunna Ravi , Voshage Aaron , Karuparti Sasidhar , Ziu Ismail , Ortiz Michael 
Published: August 2024

Abstract
Background
Complicated mild traumatic brain injury (cmTBI) is a common neurosurgical disorder that consumes a significant amount of healthcare resources without a clearly established benefit. Best practices for the management of cmTBI regarding triage, hospital admission, and the necessity for repeat imaging are controversial. Our objective is to describe the rate of radiographic progression and neurologic decline for isolated traumatic subarachnoid hemorrhage (itSAH) patients admitted to the hospital. We hypothesized that only a minority of itSAH patients suffer radiographic progression and that radiographic progression is not necessarily associated with neurologic decline.

Methods
Database queries and direct patient chart reviews were used to gather patient data. T-tests and Fisher’s exact tests were performed.

Results
A total of 340 patients with cmTBI associated with itSAH were included for analysis. The radiographic progression rate was 5.6%. There was no statistically significant association between age, gender, GCS at presentation, anticoagulation status, and risk of radiographic progression. However, subgroup analysis on anticoagulated patients did show those on warfarin had a statistically significant risk of radiographic progression (p = 0.003). No patient developed neurologic decline, irrespective of whether they developed radiographic progression.

Conclusion
Secondary triaging, hospital admission, ICU stay, and repeat HCT might not be necessary for awake, GCS 13–15 patients with itSAH without any other significant injuries. In the case of anticoagulant use, but not necessarily antiplatelet use, the medication should be reversed, and admission should be considered.
Association between statin intensity and femoropopliteal stent primary patency in peripheral arterial disease
Authors: Seyferth Elisabeth R. , Song Helen , Vance Ansar Z. , Clark Timothy W. I. 
Published: August 2024

Abstract
Background
Statins are widely used in coronary and peripheral arterial disease, but their impact on patency of stents placed for peripheral arterial disease is not well-studied. The purpose of this study was to evaluate femoropopliteal stent primary patency according to statin intensity at the time of stent placement and compare this effect to other covariates that may influence stent patency.

Materials and methods
A retrospective review identified 278 discrete femoropopliteal stent constructs placed in 216 patients over a 10-year period; Rutherford categories were 2 (3.6%), 3 (12.9%), 4 (21.2%), 5 (49.6%), and 6 (12.6%). Stent locations were common femoral (1.8%), common femoral/superficial femoral (0.7%), superficial femoral (50.7%), superficial femoral/popliteal (32.7%) and popliteal (14.0%) arteries; 63.3% of stents were paclitaxel-eluting. Primary patency of each stent construct was determined with duplex ultrasound, angiography, or computed tomographic angiography. Greater than 50% restenosis or stent occlusion was considered loss of patency. Cox proportional hazard and Kaplan–Meier modeling were used to assess the effect of statin use and additional covariates on stent patency.

Results
Patients on any statin at the time of stent placement were half as likely to undergo loss of primary unassisted patency as patients on no statin therapy (hazard ratio, 0.53; 95% confidence interval, 0.19–0.87; P = .004). Moderate/high intensity statin therapy conferred 17 additional months of median stent patency compared to the no statin group. Antiplatelet therapy, anticoagulant therapy, drug-eluting stents (versus bare metal or covered stents), and Rutherford class were not predictive of stent patency (P = 0.52, 0.85, 0.58, and 0.82, respectively).

Conclusion
Use of statin therapy at the time of femoropopliteal stent placement was the most predictive examined variable influencing primary unassisted patency.
Efficient post-quantum secure deterministic wallet scheme
Authors: Hu Mingxing , Liu Zhen , Zhou Yunhong 
Published: August 2024

AbstractSince the advent of Bitcoin, cryptocurrencies have gained substantial popularity, and crypto wallets have evolved into the predominant tool for safeguarding and managing cryptographic keys to access cryptocurrency funds. Deterministic wallets are proposed as an advanced wallet mechanism to provide benefits such as low-maintenance, easy backup and recovery, and support for functionalities required by cryptocurrencies. Alkeilani Alkadri et al. (ACM CCS’20) presented the first post-quantum secure deterministic wallet scheme, but it exhibits a gap to bridge before achieving practical applicability, as reflected in both their concrete parameters size and computational efficiency. In this paper, we propose an efficient post-quantum secure deterministic wallet scheme. In particular, we present a new construction method for deterministic wallets, prove the security in the quantum random oracle model, and provide an efficient instantiation. The comparison result, with the work of Alkeilani Alkadri et al. (ACM CCS’20), shows our work has a comprehensive improvement on efficiency, e.g., the pk size is $$\approx 40.7$$

≈
40.7

times shorter, sk is $$\approx 9.2$$

≈
9.2

times shorter, and the signing time is $$\approx 3.1$$

≈
3.1

times faster.
Is there an increased revision rate due to early tibial component loosening with a modern total knee arthroplasty design? A retrospective analysis from a large volume arthroplasty centre
Authors: van Duren Bernard H. , France Jonathan , Berber Reshid , Matar Hosam E. , James Peter J. , Bloch Benjamin V. 
Published: August 2024

Abstract
Background
The Attune TKR was introduced in 2011 as a successor to its predicate design The PFC Sigma. However, following reports of early failures, there are ongoing concerns related to increased loosening rates. Given the concerns, this study aimed to compare revision rates of the Attune implant to an established predicate, and other implant designs used in a high-volume arthroplasty center.

Methods
We identified 10,202 patients who underwent primary cemented TKR at our institution with a minimum of 1 year follow-up, involving 2406 Attune TKR (557 S +), 4642 PFC TKR, 3154 other designs. Primary outcomes were revision for all-causes, aseptic loosening of any component, and aseptic tibial loosening. Kaplan–Meier survival and Cox regression models were used to compare groups. Matched cohorts were selected for radiographic analysis.

Results
308 knees were revised. The Attune cohort had the lowest risk of revision, with a rate of 2.98 per 1000 implant-years while the PFC and All Other Implant groups had a rate of 3.15 and 4.4 respectively. Aseptic loosing was the most common cause for revision, with 76% (65/88) involving the tibia. Survival analysis showed no significant differences between the Attune and other cohorts. Radiolucent lines were detected in 7.1% of the Attune S + group, 6.8% of the standard Attune group, and 6.3% of the PFC group, with no significant differences found between them.

Conclusion
This study represents the largest non-registry review of the Attune TKR in comparison to a predicate and other designs. There was no significant increased revision rate for all-cause revision or aseptic loosening, or peri-implant radiolucencies. It appears that increased loosening may not be as concerning as originally thought.

Level of Evidence
Level III.
Attitude and help-seeking behavior towards suicide among medical students in Jammu and Kashmir
Authors: Raj Rajnish , Wani Zaid Ahmad , Nazir Deeba , Haq Inaamul , Rehman Andleeba , Jasrotia Tanmay , Kumar Kulbushan , Meer Rameez Ahmad , Bhat Maajid Shafi 
Published: August 2024

Abstract
Introduction
The ongoing training process and medical curriculum of the medical profession are crucial for equipping them with necessary knowledge and skills, but it can also be challenging to balance the demands of a busy learning schedule, making this period stressful. This study has been aimed to determining the attitude towards suicide and their help-seeking behavior among medical undergraduates in the union territory of Jammu and Kashmir (J&K).

Methodology
Across medical colleges of the J&K region, an online survey was conducted among 275 medical undergraduates using Attitude Towards Suicide Scale-20 and General Help-Seeking Behavior Questionnaire. An independent sample t-test and one-way ANOVA were carried out for statistical analysis in SPSS 25.0.

Result
The mean age of the participants was 22.05 years, including 116 male and 159 female students. Psychiatry posting was attended by 31.3% (N = 86) students. Students showed greater acceptability over suicide is preventable, and it is a cry for help. For personal and emotional problems, subjects preferred seeking help from informal sources, while for suicidal ideations, they exhibited inclination towards formal sources.

Conclusion
Findings of the result should be utilized in preventing negative mental health consequences and in planning assistance to them. Medical students within the institution should receive counselling services from the psychiatry department in a non-stigmatizing manner.
A chalcone derivative SBD-2 exerts anticancer effects in human colorectal cancer cells
Authors: Zheng Bowen , Lin Wanjun , Zhang Na , Huang Xiaoming , Du Jingjing , Shen Yunfu , Chen Junhe , Lin Qianyu , Yang Zhuya , Ma Wenzhe 
Published: August 2024

Abstract
Background
In this study, the potential anticancer activity and mechanism of action of SBD-2, a chalcone isolated from Shuteria involucrata, was investigated in colorectal cancer (CRC) cells.

Results
SBD-2 inhibited the proliferation of Caco-2 cells in a dose-dependent manner. It elicited the cells arrested in the G2/M phase and induced apoptosis. Mechanistically, SBD-2 inhibited Akt phosphorylation, which suppressed the ani-apoptotic protein Bcl-2 and cell cycle regulator Cyclin B1, leading to apoptosis ad cycle arrest, respectively.

Conclusions
The presented chalcone compound SBD-2 from Shuteria involucrata induced apoptosis and cell cycle arrest through inhibiting Akt pathway, highlighting the possibility to develop as a new agent for CRC treatment.
Sleep quality and the cortisol and alpha-amylase awakening responses in adolescents with depressive disorders
Authors: Krempel Rebekka , Jarvers Irina , Ecker Angelika , Schleicher Daniel , Brunner Romuald , Kandsperger Stephanie 
Published: August 2024

Background
Depressive disorders in adolescents affect all aspects of life and impose a very large burden of disease. Sleep is frequently affected by depression and is crucial for facing challenges during development. One of the postulated reasons for depression-induced sleep disruption is dysregulation of the physiological stress system.

Aims
To investigate the links of adolescent depressive disorders with subjective sleep quality, objective sleep quality, and the course of cortisol and alpha-amylase after awakening.

Method
We compared subjective sleep quality (via daily questionnaires) and objective sleep quality (via actigraphy measurement) of 35 adolescents with depressive disorders and 29 healthy controls over 7 consecutive days. In addition, saliva samples were collected on 3 days to examine cortisol and alpha-amylase patterns after awakening.

Results
No significant differences in cortisol or alpha-amylase awakening responses were observed between participants with depressive disorders and healthy controls. We found severe reductions in subjective sleep quality in the depression group (Z = −5.19, P < 0.001, d = 1.80) and a prolonged actigraphy-measured sleep onset latency (Z = −2.42, P = 0.015, d = 0.64) compared with controls. Reductions in subjective sleep quality were partially correlated with objective sleep measures (sleep onset latency: r = −0.270, P = 0.004, sleep efficiency: r = 0.215, P = 0.017).

Conclusions
Sleep onset latency seems to aggravate depressive symptoms and to have an important role in perception of sleep quality. Adolescents with depressive disorders should be supported regarding the establishment of good sleep hygiene and avoiding activities that may impede falling asleep.
Structural Racism and Treatment Delay Among Black and White Patients With Breast Cancer
Authors: Reeder-Hayes Katherine E. , Jackson Bradford E. , Kuo Tzy-Mey , Baggett Chris D. , Yanguela Juan , LeBlanc Matthew R. , Roberson Mya L. , Wheeler Stephanie B. 
Published: August 2024

PURPOSE
Structural racism (SR) is a potential driver of health disparities, but research quantifying its impacts on cancer outcomes has been limited. We aimed to develop a multidimensional county-level SR measure and to examine the association of SR with breast cancer (BC) treatment delays among Black and White patients.

METHODS
The cohort included 32,095 individuals from the North Carolina Central Cancer Registry with stage I to III BC diagnosed between 2004 and 2017 and linked to multipayer insurance claims from the Cancer Information and Population Health Resource. County-level data were drawn from multiple public sources aggregated in the Robert Wood Johnson County Health Rankings database. Racial gaps in eight social determinants across five domains were quantified at the county level and ranked on a 0-100 minimum-maximum scale. Domain scores were averaged to create a SR Composite Index (SRCI) score. We used multilevel logistic regression with random intercepts and multiple cross-level interaction terms to evaluate the association between county-level SRCI and patient-level treatment delays, adjusting for patient-level characteristics and stratified by race.

RESULTS
The SRCI score ranged from 21 to 75 with a median (IQR) of 39.0 (31.8, 45.7). For Black patients, a 10-unit increase in SRCI score was associated with increased odds of delay (Adjusted odds ratios [aOR], 1.25; 95% confidence limits [CL], 1.08 to 1.45). No such association was found for White patients (OR, 1.05; 95% CL, 0.97 to 1.15).

CONCLUSION
Area-level SR measured by a composite index is associated with higher odds of BC treatment delays among Black, but not White patients. Increasing county-level SR is associated with increasing Black-White disparities in treatment delay. Further research is needed to refine the measurement of SR and to examine its association with other cancer care disparities.
Abdominal Obesity–Metabolic Syndrome 3 Misclassified as Type 1 Diabetes Mellitus
Authors: Radi Suhaib , Bashamakh Lujain , Mandourah Hayfa , Alsharif Sarah 
Published: August 2024

Abstract
Age is no longer the most important differentiating feature between type 1 and type 2 diabetes, as obesity and metabolic syndrome are on the rise in the pediatric population. Here we present a case of a 30-year-old male individual initially diagnosed with uncontrolled type 1 diabetes mellitus (T1DM) since the age of 15, and treatment with high insulin doses has been unsuccessful. He was later identified as having abdominal obesity–metabolic syndrome 3 (AOMS3) based on strong family history and the presence of insulin resistance features. AOMS3 is characterized by early-onset coronary artery disease, central obesity, hypertension, and diabetes. Early detection of this condition is crucial to implement timely interventions and preventing the onset of complications.
Ectopic Cushing Syndrome Secondary to Diffuse Idiopathic Neuroendocrine Cell Hyperplasia—A Report of 2 Cases
Authors: Lopez Fanas Raul , Goettemoeller Travis , Cedeno Keerthi , Manavalan Anjali D 
Published: August 2024

Abstract
Ectopic ACTH secretion (EAS) accounts for 10% to 20% of all Cushing syndrome cases. Diffuse intrapulmonary neuroendocrine cell hyperplasia (DIPNECH), a poorly understood lung disease, is characterized by abnormal proliferation of neuroendocrine cells in the bronchial mucosa. It is thought to be a precursor of pulmonary carcinoid and has been associated with EAS in a handful of cases. We present 2 patients with clinical, radiological, and pathological features of DIPNECH who presented with florid Cushing syndrome secondary to EAS evidenced by rapid onset of symptoms, elevated plasma ACTH, and cortisol levels, and failed high-dose dexamethasone suppression testing. Treatment of hypercortisolism included excision of the involved lung and medical therapy with steroidogenesis inhibitors. Despite the aggressive initial management, hypercortisolism persisted. This case series highlights the importance of considering DIPNECH as a cause for Cushing syndrome in the appropriate clinical scenario and underscores the likelihood that surgery may not be curative because of the diffuse nature of this disease. Given the high mortality associated with EAS, prompt medical therapy, appropriate prophylaxis, and bilateral adrenalectomy can be lifesaving measures when initial surgery fails.
Loss of ATRX Protein Expression in an Aggressive Null Cell Pituitary Tumor
Authors: Lamback Elisa , Miranda Renan Lyra , Ventura Nina , Chimelli Leila , Gadelha Mônica R 
Published: August 2024

Abstract
Somatic alpha thalassemia/mental retardation syndrome X-linked (ATRX) pathogenic variants have been shown to predict a malignant phenotype in neuroendocrine tumors. They were recently identified in aggressive pituitary tumors and carcinomas, mainly of corticotrophic origin. To our knowledge, these tumors are rare in a general cohort of pituitary tumors, with no cases described in null cell tumors. These variants can lead to loss of protein expression as revealed by immunohistochemistry. We describe a case of an aggressive null cell pituitary tumor with loss of ATRX expression. The patient underwent two transsphenoidal surgeries and radiotherapy and exhibited tumor growth despite conventional therapy. Analysis of the tumor samples revealed loss of ATRX expression in both surgical specimens, suggesting that ATRX may be a useful biomarker for the early identification of aggressive pituitary tumors.
A Collective Fantasia of the Financial Age in Early 1990s China: Erotic-Speculative Sensation, Neoliberal Labor Heroine, and Presentist Worldly Wisdom
Authors: Zhang Yu 
Published: August 2024

Abstract
When the notion of “finance” reentered ordinary Chinese people's lives since the “Reform and Opening Up,” how were “finance and economics” (caijing) perceived and felt? This essay focuses on the mainland critics’ reviews of the “finance-themed” novels by the Hong Kong entrepreneur-cum-writer Leung Fung Yee (b. 1949) and discusses how “Leung fever” (1992 – 93) provided a medium for a collective imagination of the financial age. Leung's fiction introduced “sensuous and lively” financial knowledge particularly attractive to a financially uneducated mainland readership who nonetheless desired to engage in adventurous economic activities. This essay is situated in the intersection of finance and literary practice and highlights the ways these critics’ interpretations of Leung's novels helped instruct readers in how to feel, experience, and survive the financial age and legitimize the new economic behaviors in everyday life. This new age was first and foremost experienced as an “erotic-speculative sensation” in which an erotic adventure was experienced similar to the financial behavior of speculation. The mainland critics envisioned the figure of “the neoliberal labor heroine,” one who creatively utilizes the intervals to maximize productive value and who performs “presentist worldly wisdom” to strategically navigate life and achieve optimal outputs and success in a disorienting world.
Surface error effect on reflectivity and focused spot of an EUV tubular mirror machined by ultra-precision diamond turning
Authors: Wu Shan , Wang Jinshi , Cui Huaiyu , Zhao Yongpeng , Fang Fengzhou 
Published: August 2024

Grazing-incidence tubular mirrors, which provide high reflectivity and significant demagnification of the meridian and sagittal plane through a single reflection, are important optical elements in extreme ultraviolet (EUV) focusing systems. Surface errors induced by the manufacturing process have a vital impact on optical performance. In this paper, a tubular focusing mirror is directly fabricated via ultra-precision diamond turning. According to ray tracing and Rayleigh–Rice vector perturbation theory, a surface error model is established based on the measurement data from different spatial frequency ranges. The effects of figure error and roughness on the reflectivity and the focused spot are studied in detail. The results reveal that these surface errors cause a decrease in reflectivity from 88.9% to 83.2%, along with a significant increase in the root mean square spot radius, rising from 63.9 µm to 138.3 µm. This study also provides a method to bridge the machined surface geometry to the optical functionality.
Refraction displacement pulse sequence combination based on a fast steering mirror stabilization system
Authors: Zhang Yu-Xuan , Xu Jian , Gong Ke-Ling , Zhang Lin , Sun Chang-Zhi , Wang Zi-Hao , Lan Ying-Jie , Zhang Xue-Kun , Bo Yong , Peng Qin-Jun 
Published: August 2024

In this paper, a fast steering mirror (FSM) stabilization system is proposed for a refraction displacement pulse sequence beam-combining (PSBC) technique. The FSM system can effectively suppress pointing jitter in the PSBC and achieve high beam-quality laser output. A proof-of-principle experiment on the PSBC with FSM is performed with three ∼100W pulsed beams. The experimental results indicate that a combined output power of 302.5 W is achieved, corresponding to a high combining efficiency of 98.7%. Meanwhile, excellent pointing stability with root mean square pointing jitter = 4.2 µrad is confirmed with a beam quality β of 2.
The effect of low‐intensity suspension training with blood flow restriction onGH,IGF‐1, and their association with physical fitness in young women
Authors: Aram Shiva , Khodaei Kazem , Zolfaghar Didani Mohamadreza 
Published: August 2024

AbstractBlood flow restriction (BFR) has been incorporated in resistance training for over 20 years. We aimed to investigate the impact of low‐intensity suspension training with BFR (LIST+BFR) on GH, IGF‐1, and their association with physical fitness in young women. Thirty‐six active women participated and were randomly assigned to either the high‐intensity suspension training (HIST), LIST+BFR, or control (CON) groups. Training groups exercised three sessions weekly for 8 weeks. The CON only engaged in regular physical activity. Fasting serum hormones and physical fitness were assessed 48 h before and after the training intervention. GH and IGF‐1 levels significantly higher in the LIST+BFR compared to the HIST and CON. These hormones were significantly higher by HIST, compared to CON. LIST+BFR led to significant enhancements in muscular strength and endurance compared to HIST and CON. Additionally, HIST significantly higher than compared to CON. Sprinting and agility time lower in both suspension training groups rather than the CON. No significant between‐groups differences were found in weight. There was a large or moderate correlation between GH and IGF‐1 and muscular strength, endurance, sprint, and agility performance. LIST+BFR could more enhanced GH, IGF‐1, and muscular strength and endurance in females than HIST.
Matrix stretching
Authors: Futorny Vyacheslav , Neklyudov Mikhail , Zhao Kaiming 
Published: August 2024

Abstract
We consider the tensor products of square matrices of different sizes and introduce the stretching maps, which can be viewed as a generalized matricization. Stretching maps conserve algebraic properties of the tensor product, but are not necessarily injective. Dropping the injectivity condition allows us to construct examples of stretching maps with additional symmetry properties. Furthermore, this leads to the averaging of the tensor product and possibly could be used to compress the data.