bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Unraveling the Diagnostic Dilemma: Unusual Presentation of Huntington’s Disease with Predominant Psychiatric Symptoms and Late-Onset Motor Manifestations”
Authors: Ibrahim M. I. M. M. N. , Iderapalli M. 
Published: August 2024

IntroductionHuntington’s Disease is a neurodegenerative disease inherited in an autosomal dominant fashion.The underlying genetic defect is unstable CAG trinucleotide repeat expansion with a repeat length longer than 36 resulting in pathological aggregation of abnormal protein causing cell death.The clinical symptoms encompass 3 main domains-motor,cognitive and psychiatric.The psychiatric symptoms often in atypical form appear decades before other symptoms causing significant impact on patient’s functioning and quality of life.Here, we discuss an unusual presentation of Huntington’s Disease causing diagnostic dilemma.ObjectivesCase report discussing the unusual presentation of Huntington’s Disease.MethodsCase: Mr X is a 61 year old Caucasian male.He had an uneventful birth and early childhood attaining milestones appropriately. He experienced childhood adversity in the form of sexual abuse between ages 2-14 years. His mental health difficulties started following sexual abuse when he attempted to end his life by hanging and overdosing at age 15. He got married twice, both of which broke down. There is a history of significant alcohol abuse between ages 40-50. Following this, he had a myocardial infarction and a stroke requiring stenting.He presented to Psychiatric Outpatient Services in 2011 with auditory hallucinations, social anxiety with panic attacks, OCD type rituals, claustrophobia and feeling hot all the time. He was started on an antipsychotic medication for psychosis ,but clinically deteriorated. He started having anger outbursts, marching on the spot ,and head banging. He was diagnosed with Huntington’s Chorea in 2021 after he had developed chorea. He currently has low mood and is head banging for hours.ResultsPsychiatric symptoms in HD can span a variety of domains but most common are symptoms of frontal lobe dysfunction-disinhibition, poor attention, irritability, impulsivity and personality change. Apathy, emotional blandness and social withdrawal are also prominent features.Mr X had strong family history of Paranoid Schizophrenia (aunt and cousin).There was no family history of HD. His mental health problems started early in life with DSH, Depression and Harmful use of Alcohol. He presented predominantly with psychotic symptoms like auditory hallucinations, social anxiety, paranoia. Motor symptoms started late which he incorporated into voluntary movements like head banging which made it difficult to differentiate from deliberate self harm.ConclusionsPsychiatric symptoms constitute the core of HD. Studies have shown that though depression and personality change are typical of HD, there are number of other psychiatric symptoms that can impair quality of life. Early diagnosis and treatment of these symptoms will help patients and families to cope better with severe symptoms of this progressive disease.Disclosure of InterestNone Declared
Control of fate specification within the dorsal head of Drosophila melanogaster
Authors: Teeters Gary , Weasner Bonnie M. , Ordway Alison J. , Weasner Brandon P. , Kumar Justin P. 
Published: August 2024

ABSTRACT
During development, unique combinations of transcription factors and signaling pathways carve the nascent eye-antennal disc of the fruit fly Drosophila melanogaster into several territories that will eventually develop into the compound eye, ocelli, head epidermis, bristles, antenna and maxillary palpus of the adult head. Juxtaposed patterns of Hedgehog (Hh) and Decapentaplegic (Dpp) initiate compound eye development, while reciprocal domains of Dpp and Wingless (Wg) induce formation of the antennal and maxillary palp fields. Hh and Wg signaling, but not Dpp, contribute to the patterning of the dorsal head vertex. Here, we show that combinatorial reductions of the Pax6 transcription factor Twin of Eyeless and either the Wg pathway or the Mirror (Mirr) transcription factor trigger a transformation of the ocelli into a compound eye and the neighboring head epidermis into an antenna. These changes in fate are accompanied by the ectopic expression of Dpp, which might be expected to trigger these changes in fate. However, the transformation of the field cannot be replicated by increasing Dpp levels alone despite the recreation of adjacent Hh-Dpp and Wg-Dpp domains. As such, the emergence of these ectopic organs occurs through a unique regulatory path.
Reduced connexin-43 expression, slow conduction and repolarisation dispersion in a model of hypertrophic cardiomyopathy
Authors: Lim Seakcheng , Mangala Melissa M. , Holliday Mira , Cserne Szappanos Henrietta , Barratt-Ross Samantha , Li Serena , Thorpe Jordan , Liang Whitney , Ranpura Ginell N. , Vandenberg Jamie I. , Semsarian Christopher , Hill Adam P. , Hool Livia C. 
Published: August 2024

ABSTRACT
Hypertrophic cardiomyopathy (HCM) is an inherited heart muscle disease that is characterised by left ventricular wall thickening, cardiomyocyte disarray and fibrosis, and is associated with arrhythmias, heart failure and sudden death. However, it is unclear to what extent the electrophysiological disturbances that lead to sudden death occur secondary to structural changes in the myocardium or as a result of HCM cardiomyocyte electrophysiology. In this study, we used an induced pluripotent stem cell model of the R403Q variant in myosin heavy chain 7 (MYH7) to study the electrophysiology of HCM cardiomyocytes in electrically coupled syncytia, revealing significant conduction slowing and increased spatial dispersion of repolarisation – both well-established substrates for arrhythmia. Analysis of rhythmonome protein expression in MYH7 R403Q cardiomyocytes showed reduced expression of connexin-43 (also known as GJA1), sodium channels and inward rectifier potassium channels – a three-way hit that reduces electrotonic coupling and slows cardiac conduction. Our data represent a previously unreported, biophysical basis for arrhythmia in HCM that is intrinsic to cardiomyocyte electrophysiology. Later in the progression of the disease, these proarrhythmic phenotypes may be accentuated by myocyte disarray and fibrosis to contribute to sudden death.
Novel procedure for hepatic venous outflow block after liver resection: A case report
Authors: Higashi Hisanobu , Abe Yuta , Abe Kodai , Nakano Yutaka , Tanaka Masayuki , Hori Shutaro , Hasegawa Yasushi , Yagi Hiroshi , Kitago Minoru , Kitagawa Yuko 
Published: August 2024

BACKGROUND
Postoperative complications like remnant hepatic vein (HV) outflow block and liver torsion can occur after right hepatectomy. Hepatic falciform ligament fixation is typically used to prevent liver torsion. We report a novel procedure to manage outflow block.
CASE SUMMARY
An 80-year-old man developed HV outflow block after remnant right hepatectomy, despite liver fixation and intraoperative HV flow check. He had a history of cholangiocellular carcinoma and had undergone posterior segmentectomy and choledojejunostomy. The falciform ligament fixation was inadequate to maintain liver position. Emergency surgery was performed, using an omental flap and mobilized right side colon with ileocecal region to prevent liver dislocation due to intraabdominal adhesion. His postoperative course was uneventful.
CONCLUSION
This is the first report providing a novel surgical procedure when the falciform ligament is insufficient for remnant liver fixation.
Homemade open-source full-Stokes polarimeter based on division of amplitude
Authors: del Río-Lima A. , Gutiérrez-Valdés A. , Mojica-Casique C. , Ballesteros-Flores F. , Villanueva-Reyes I. A. , Colín-Rodríguez R. , Gardea-Flores C. A. , Poveda-Cuevas F. J. , Seman J. A. 
Published: August 2024

We present an open-source homemade Stokes polarimeter for real-time determination of the state and degree of polarization of a light beam by measuring all four Stokes parameters. Our design uses standard, commercially available optical components, mounted on a 3D printed base. Our user-friendly software allows visualization of the measured polarization state on the Poincaré sphere. We model the polarimeter using realistic Mueller matrices and present a detailed methodology to characterize every optical component and calibrate the instrument. The accuracy of the polarimeter largely depends on the quality of the chosen optical components, which in turn affects its price. Depending on this choice, the instrument can be used for applications ranging from simple didactic purposes to more accurate, research-grade measurements. In our case, we estimate an accuracy better than ±2.2∘ in the determination of the state of polarization and ±6.0% in the degree of polarization. This makes our instrument useful for the correct alignment of polarization-maintaining fibers, as it allows one to quickly and efficiently match the polarization axis of the light to the polarization axes of the fiber. The high sampling rate of 60 k samples/s opens up the possibility to analyze the polarization of rapidly fluctuating signals such as light pulses. Moreover, the flexibility of our design permits to analyze light signals in a broad range of wavelengths, from deep UV to infrared, after opportune change of the optical components, representing an alternative low cost to more expensive commercial instruments.
Mode division multiplexing of an all-fiber three-mode selective coupler
Authors: Su Hang , Zhao Yunhe , Ma Yuehui , Chen Siyu , Jiang Chen , Mou Chengbo , Liu Yunqi 
Published: August 2024

The emergence of space division multiplexing technology has enabled large-scale expansion of fiber transmission capacity, and the mode selection coupler (MSC) based on few-mode fibers (FMFs) has been studied as a promising technique for SDM. In this work, we demonstrated an all-fiber three-mode selective coupler formed with a pre-tapered single-mode fiber and two types of FMF by fused biconical taper technology. The simulation results show that efficient mode conversion can be achieved by optimizing the degree of pre-tapered fibers, fiber core distance, and coupling zone length. Both simulated and experimental results show that the FMF in the MSC is capable of selectively exciting LP11, LP21, or LP31 modes. The simulation illustrates that the conversion purity is higher than 50%, and the bandwidth can reach 360 nm, 395 nm, and 180 nm when the two high-order modes are LP11/LP11, LP11/LP21, and LP11/LP31, respectively. Furthermore, the MSC is capable of mode multiplexing without the need of a mode converter and can generate high-quality orbital angular momentum modes. This MSC design is scalable to accommodate a larger number of mode selective couplings, so it can be easily integrated with broadband fiber optical communication systems.
Ultrafast 550-W average-power thin-disk laser oscillator
Authors: Seidel Moritz , Lang Lukas , Phillips Christopher R. , Keller Ursula 
Published: August 2024

SESAM modelocked oscillators are interesting for applications in strong-field physics such as high-harmonic generation and attosecond science at high repetition rates or frequency combs in the ultraviolet. Here we present a SESAM modelocked ultrafast thin-disk laser oscillator providing 550W of average output power with 852fs pulses at 5.5MHz repetition rate. To reach this significant power scaling, a replicating cavity design for modelocked oscillators is utilized. The oscillator delivers 103 MW of peak power with a pulse energy of 100 µJ at a beam quality ofM2<1.2, with a high optical-to-optical efficiency of 35%. The advances in SESAM design and manufacturing that enabled this result are discussed, as well as practical challenges when scaling oscillators to the kW-class. When combined with established pulse compression technologies, this oscillator can enable simpler systems by avoiding the complexity of chirped pulse amplifier chains. Additionally, high power oscillators support a much lower noise floor due to the reduced influence of shot noise, which may provide a route to more sensitive pump-probe measurements.
Robust continuous-variable quantum key distribution in the finite-size regime
Authors: Xu Yuehan , Wang Tao , Liao Xiaojuan , Zhou Yingming , Huang Peng , Zeng Guihua 
Published: August 2024

Quantum key distribution (QKD) has been proven to be theoretically unconditionally secure. However, any theoretical security proof relies on certain assumptions. In QKD, the assumption in the theoretical proof is that the security of the protocol is considered under the asymptotic case where Alice and Bob exchange an infinite number of signals. In the continuous-variable QKD (CV-QKD), the finite-size effect imposes higher requirements on block size and excess noise control. However, the local local oscillator (LLO) CV-QKD system cannot be considered time-invariant under long blocks, especially in cases of environmental disturbances. Thus, we propose an LLO CV-QKD scheme with time-variant parameter estimation and compensation. We first establish an LLO CV-QKD theoretical model under the temporal modes of continuous-mode states. Then, a robust method is used to compensate for arbitrary frequency shift and arbitrary phase drift in CV-QKD systems with longer blocks, which cannot be achieved under traditional time-invariant parameter estimation. Besides, the digital signal processing method predicated on high-speed reference pilots can achieve a time complexity of O(1). In the experiment, the frequency shift is up to 89.05 MHz/s and phase drift is up to 3.036 Mrad/s using a piezoelectric transducer (PZT) to simulate the turbulences in the practical channel. With a signal-to-interference ratio (SIR) of −51.67  dB, we achieve a secret key rate (SKR) of 0.29 Mbits/s with an attenuation of 16 dB or a standard fiber of 80 km. This work paves the way for future long-distance field-test experiments in the finite-size regime.
Heilige Räume in der Hebräischen Bibel
Authors: Bunzel Marlen 
Published: August 2024

Zusammenfassung
Der vorliegende Text setzt bei den Begrifflichkeiten an, die die Hebräische Bibel für heilige Räume bereithält. Er fokussiert sich dabei vor allem auf Texte aus den Büchern Genesis und Exodus, da sich hier zentrale heilige Räume der Hebräischen Bibel finden: der heilige Ort in Ex 3 – und Gen 28, der heilige Berg in Ex 19 – und Gen 22, sowie das mobile Zelt-Heiligtum ab Ex 25, welches im Heiligen Land zu einem festen Heiligtum, dem Tempel wird. Deutlich wird, dass es sich bei den heiligen Räumen der Hebräischen Bibel nicht um statische, begrenzte Räume handelt, sondern um Beziehungsräume, die sich in Relation zu Gott, dem unbegrenzten heiligen Raum (HaMakom), entfalten.
»Gott wohnt auch im Bimsbeton«
Authors: Lieb Stefanie 
Published: August 2024

Zusammenfassung
Der Einsatz von Sichtbeton als gestalterischem Material für den Bau von Kirchen in den 1950er bis 70er Jahren galt damals und gilt bis heute oftmals als problematisch, da häufig mit dem Material und seiner »profanen« Wirkung keine »sakrale« Atmosphäre verbunden werden kann. Im Beitrag wird untersucht, wie das Alltagsmaterial Beton zu einem Symbolträger und Raumgestalter im Kirchenbau werden konnte und welche Rechtfertigungsstrategien hier von Seiten der Architekturgestaltenden zum Tragen kamen.
In Bewegung
Authors: Schulz Ansgar , Schulz Benedikt 
Published: August 2024

Zusammenfassung
Die Kirche St. Rochus in Düsseldorf ist in den 1950er Jahren als Ersatz eines kriegszerstörten Kirchenschiffes errichtet worden. Ihre radikale Architektur bietet Raum, in dem Menschen eine höhere Wirklichkeit erfahren können. Doch um heiliger Raum sein zu können, müssen heilige Handlungen gut in ihm vollziehbar sein. Die Umgestaltung des Kirchenraumes hat zum Ziel, Raum und Liturgie aufeinander abzustimmen, miteinander verschmelzen zu lassen.
Heiligende Räume
Authors: Menzel Kerstin 
Published: August 2024

Zusammenfassung
Der Beitrag fragt danach, inwiefern sich der in der baulichen Form enthaltene sakrale Charakter von Kirchenräumen in säkularen Neunutzungen und deren Praktiken niederschlägt. Dafür werden zunächst unterschiedliche Weisen beschrieben, in denen eine neue Nutzung sich auf die sakralen Raumdimensionen beziehen kann. Anhand eines Fallbeispiels wird dann gezeigt, wie sich der Kirchenraum überraschend und beharrlich in eine sportlich-soziale Nutzung einspielt.
Shared Space
Authors: Nützel Gerdi 
Published: August 2024

Zusammenfassung
Die Umnutzung von Sakralräumen durch Religionsgemeinschaften anderer kultureller, konfessioneller und religiöser Prägung eröffnet neue Chancen für die interreligiöse Konvivenz. Das Raumkonzept Shared Space gibt inspirierende Anregungen für die innen- und außenarchitektonischen Raumtransformationen, aber auch für Perspektiven, die durch Umnutzungen für gesellschaftliche, interreligiös-theologische und spirituelle Kooperationsräume entstehen können.
»Heiliges Russland« und »Russische Welt«
Authors: Flogaus Reinhard 
Published: August 2024

Zusammenfassung
Schon zu Beginn seiner Amtszeit hat der russische Patriarch Kirill das seit 2001 von Wladimir Putin propagierte Narrativ einer »Russischen Welt«, das heißt eines durch Sprache, Kultur, traditionelle Werte und orthodoxen Glauben geeinten Volkes, aufgegriffen und es mit der Idee der »Heiligen Rus’« und ihrer eschatologischen Mission verbunden. Zahlreiche Motive dieser im 16. Jahrhundert entstandenen Vorstellung eines heiligen Landes und eines auserwählten Volkes, das von einem orthodoxen Herrscher regiert wird und das mit göttlichem Beistand gegen Unglauben und die Laster kämpft, kehren in den gegenwärtigen Predigten und Ansprachen des Patriarchen wieder. Doch Kirills theologische Rechtfertigung des Ukrainekrieges als eines Kampfes für die Einheit der »Heiligen Rus’« und gegen die Pseudowerte des Westens hat seiner Kirche schweren Schaden zugefügt und dazu geführt, dass sich die Ukrainische und die Lettische Orthodoxe Kirche vom Moskauer Patriarchat getrennt haben und andere Teile der ROK sich klar von ihrem Kirchenoberhaupt distanzieren.
Numerical study on surface treatment of vibration-impact composite electric spark based on ABAQUS
Authors: Feng Hongfeng , Lu Yongxin , Wen Pengjun , Zhou Yuwei , Li Wenya 
Published: August 2024

Abstract
Through numerical simulation, this study explores the effect of vibration-impact composite electric spark (VIES) surface treatment technology on the temperature and thermal stress fields of 2024-T3 aluminum alloy surfaces. The depth of the molten pool and residual stress are evaluated using orthogonal experiments to score different experimental schemes, resulting in three experimental parameters categorized as good, medium, and poor. The study then examines the temperature and thermal stress fields for these three sets of parameters during the strengthening process. The results indicate that, considering the temperature field, the distance between the heat source and the work piece directly affects the heating efficiency and temperature distribution. An appropriate distance and sufficient dwell time are essential for creating the ideal molten pool thickness. Analysis of the stress field results shows that in the early stage of strengthening, the inertia force of the small spheres is dominant, while in the later stage, the stress field created by the electric current becomes decisively dominant. This indicates that the electric current is the core of the three influencing factors in the orthogonal experiment.
Implant bone screw characteristics of a printed PLA-based material
Authors: Dvorak Karel 
Published: August 2024

Abstract
ASTM F543 specifies the testing characteristics of bone screws. It consists of 4 phases of separate tests, 3 of which are carried out according to a standard procedure using strictly prescribed material. Testing according to this standard is part of the standardization and certification process for bone implants. The PUR 30 PCF material simulates bone for the respective test. The standardized testing results are primarily used to compare the characteristics of the implants tested. At the same time, the information obtained is essential for the verification of real bone screw implantation procedures. In addition to the design of implants and fixation elements, the purpose of using the results of testing using a surrogate material may be, for example, to teach implantation procedures or to train and simulate real implantation procedures, especially in complicated cases. The advantage of using bodies made of poly lactic acid (PLA) material, prepared by additive technology, lies mainly in the possibility of realizing free shapes corresponding to the shapes of natural bone. The present content introduces the problem of defining the structure of test bodies made of additively prepared PLA material and presents the results of comparative testing with PUR 30 PCF material.
Surface plasmon polariton–enhanced upconversion luminescence for biosensing applications
Authors: Le Duc , Kreivi Marjut , Aikio Sanna , Heinilehto Noora , Sipola Teemu , Petäjä Jarno , Guo Tian-Long , Roussey Matthieu , Hiltunen Jussi 
Published: August 2024

Abstract
Upconversion luminescence (UCL) has great potential for highly sensitive biosensing due to its unique wavelength shift properties. The main limitation of UCL is its low quantum efficiency, which is typically compensated using low-noise detectors and high-intensity excitation. In this work, we demonstrate surface plasmon polariton (SPP)-enhanced UCL for biosensing applications. SPPs are excited by using a gold grating. The gold grating is optimized to match the SPP resonance with the absorption wavelength of upconverting nanoparticles (UCNPs). Functionalized UCNPs conjugated with antibodies are immobilized on the surface of the fabricated gold grating. We achieve an UCL enhancement up to 65 times at low excitation power density. This enhancement results from the increase in the absorption cross section of UCNPs caused by the SPP coupling on the grating surface. Computationally, we investigated a slight quenching effect in the emission process with UCNPs near gold surfaces. The experimental observations were in good agreement with the simulation results. The work enables UCL-based assays with reduced excitation intensity that are needed, for example, in scanning-free imaging.
A positive scratch collapse test in anterior cutaneous nerve entrapment syndrome indicates its neuropathic character
Authors: Jacobs Monica L. Y. E. , ten Have Tom , Schaap Lotte , Scheltinga Marc R. M. , Roumen Rudi M. H. 
Published: August 2024

Abstract

Objectives
Chronic abdominal pain is occasionally caused by an abdominal wall entity such as anterior cutaneous nerve entrapment syndrome (ACNES). This syndrome is thought to occur due to intercostal nerve branches (T7–12) that are entrapped in the rectus abdominis muscles. The diagnosis is largely based on subjective clues in patient history and physical examination. A test referred to as the scratch collapse test (SCT) is used as an additional diagnostic tool in peripheral nerve entrapment syndromes such as the carpal tunnel syndrome. The aim of the present study is to investigate whether an SCT was positive in patients with suspected ACNES. If so, this finding may support its hypothesized neuropathic character.

Methods
A prospective, case–control study was performed among patients with ACNES (n = 20) and two control groups without ACNES (acute intra-abdominal pathology n = 20; healthy n = 20), all were consecutively included. ACNES was diagnosed based on previously published criteria. The SCT test was executed at the painful abdominal area in both patient groups and at a corresponding area in healthy controls. Predictive values, sensitivity, and specificity were calculated. Videos of tests were evaluated by blinded observers.

Results
SCT was judged positive in 19 of 20 ACNES patients but not in any of the 40 controls. A 95% sensitivity (confidence interval [CI]: 75–99) and optimal specificity (100%; CI: 83–100) were calculated.

Conclusions
The positive SCT supports the hypothesis that ACNES is an entrapment neuropathy. A positive SCT should be considered a major diagnostic criterion for ACNES.