bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ground‐penetrating radar investigation inside a karstified limestone reservoir
Authors: Sénéchal Guy , Rousset Dominique , Gaffet Stéphane 
Published: May 2013

In this paper, we present ground‐penetrating radar (GPR) investigations performed along a 3.7 km long tunnel located inside a lower Cretaceous limestone massif of south‐eastern France. This fractured massif is mainly characterized by water circulation and karstic structures. This kind of geological formation contains a large part of the fresh underground water resources of the world and is also considered as an analogue of Middle East oil reservoirs. Since tunnel walls are covered by thick reinforced concrete, direct geological observations are impossible.After some preliminary tests, the entire tunnel was investigated using 250 MHz shielded antennas. Data are generally of very good quality, with reflection time up to 400 ns (down to 18 m under the tunnel floor with a velocity of 9 cm/ns). We correlate the GPR signal along the tunnel with surface geological observations: the upper part of the investigated formation (Bedoulian) displays prominent stratigraphic reflectors while the lower part (Barremian) does not. Numerous diffractions are observed in both formations and can be related to karstic features.These investigations allow to better constrain the geological context along the tunnel, necessary for future hydrogeological studies. We conclude that this tunnel offers a unique opportunity of performing GPR measurements within a karstified limestone massif.
T Cell Costimulation with Anti-CD137 Monoclonal Antibodies Is Mediated by K63–Polyubiquitin-Dependent Signals from Endosomes
Authors: Martinez-Forero Ivan , Azpilikueta Arantza , Bolaños-Mateo Elixabet , Nistal-Villan Estanislao , Palazon Asis , Teijeira Alvaro , Perez-Chacon Gema , Morales-Kastresana Aizea , Murillo Oihana , Jure-Kunkel Maria , Zapata Juan M. , Melero Ignacio 
Published: May 2013

Abstract
Agonist anti-CD137 (4-1BB) mAbs enhance CD8-mediated antitumor immunity. Agonist anti-human CD137 mAbs binding to four distinct epitopes on the CD137 glycoprotein costimulated T cell activation irrespective of the engaged epitope or its interference with CD137L binding. CD137 perturbation with all these agonist mAbs resulted in Ag and Ab internalization toward an endosomal vesicular compartment. Internalization was observed in activated T lymphocytes from humans and mice, not only in culture but also in Ab-injected living animals. These in vivo experiments were carried out upon systemic i.v. injections with anti-CD137 mAbs and showed CD137 internalization in tumor-infiltrating lymphocytes and in activated human T cells transferred to immunodeficient mice. Efficient CD137 internalization required K63 polyubiquitination and endocytosed CD137-containing vesicles recruited TNFR-associated factor (TRAF) 2 and were decorated with K63 polyubiquitins. CD137 stimulation activates NF-κB through a K63-linked polyubiquitination-dependent route, and CD137-associated TRAF2 becomes K63 polyubiquitinated. Consistent with a role for TRAF2 in CD137 signaling, transgenic mice functionally deficient in TRAF2 showed delayed immunotherapeutic activity of anti-CD137 mAbs. As a whole, these findings advance our knowledge of the mechanisms of action of anti-CD137 immunostimulatory mAbs such as those currently undergoing clinical trials in cancer patients.
Identification of TMEM131L as a Novel Regulator of Thymocyte Proliferation in Humans
Authors: Maharzi Nesrine , Parietti Véronique , Nelson Elisabeth , Denti Simona , Robledo-Sarmiento Macarena , Setterblad Niclas , Parcelier Aude , Pla Marika , Sigaux François , Gluckman Jean Claude , Canque Bruno 
Published: May 2013

Abstract
In this study, we identify transmembrane protein 131–like (TMEM131L) as a novel regulator of thymocyte proliferation and demonstrate that it corresponds to a not as yet reported inhibitor of Wnt signaling. Short hairpin RNA–mediated silencing of TMEM131L in human CD34+ hematopoietic progenitors, which were then grafted in NOD-SCID/IL-2rγnull mice, resulted in both thymocyte hyperproliferation and multiple pre– and post–β-selection intrathymic developmental defects. Consistent with deregulated Wnt signaling, TMEM131L-deficient thymocytes expressed Wnt target genes at abnormally high levels, and they displayed both constitutive phosphorylation of Wnt coreceptor LRP6 and β-catenin intranuclear accumulation. Using T cell factor reporter assays, we found that membrane-associated TMEM131L inhibited canonical Wnt/β-catenin signaling at the LRP6 coreceptor level. Whereas membrane-associated TMEM131L did not affect LRP6 expression under basal conditions, it triggered lysosome-dependent degradation of its active phosphorylated form following Wnt activation. Genetic mapping showed that phosphorylated LRP6 degradation did not depend on TMEM131L cytoplasmic part but rather on a conserved extracellular domain proximal to the membrane. Collectively, these data indicate that, during thymopoiesis, stage-specific surface translocation of TMEM131L may regulate immature single-positive thymocyte proliferation arrest by acting through mixed Wnt-dependent and -independent mechanisms.
The Development of Client-Centredness in Student Occupational Therapists
Authors: Ripat Jacquie , Wener Pamela , Dobinson Kendra 
Published: May 2013

Introduction: While the occupational therapy profession emphasizes the importance of a client-centred approach, the student perspective on development of client-centredness has been absent in the research literature. The purpose of this grounded theory study was to gain an understanding of occupational therapy students' perceptions of the curricular and practice experiences that contributed to their client-centred development. Method: Study participants were recruited from three cohorts (n = 29) of an entry-level Canadian occupational therapy programme: students from two separate years of an occupational therapy programme, and graduates from the programme who were 1 year into practice. Researchers conducted six focus groups using a semi-structured interview guide; focus group transcripts were reviewed to develop a coding scheme. Emergent categories were collapsed to develop overarching themes. Findings: Six developmental themes were constructed: Internalizing client-centredness; Relationship building; Who is the client?; Systems influences; Academic/practice discrepancy; and Power and control. Each theme was of greater or lesser emphasis at different points, and participants revisited and expanded upon themes throughout their academic programme. Conclusion: Academic and placement educators can use the findings of the study to understand how student occupational therapists develop client-centredness. Educators can use this understanding to implement strategies to intentionally foster client-centred development in students at opportune times.
Factors That Influence the Occupational Engagement of Older Adults with Low Vision: A Scoping Review
Authors: McGrath Colleen E , Rudman Debbie Laliberte 
Published: May 2013

Introduction: Prior research has provided occupational therapists with an understanding of the negative impact of low vision on self care, leisure and productivity. In order to guide future low-vision rehabilitation services, an understanding of the factors that influence the occupational engagement of older adults with age-related vision loss (ARVL) is also needed. Method: A scoping review of the literature was conducted in order to identify those factors that have been shown to influence the occupational engagement of older adults with ARVL, and to identify future research needs. Findings: As identified in this scoping review, five types of factors were shown to influence occupational engagement for older adults with ARVL including: demographic variables, emotional components, behavioural components, diagnostic components, and environmental aspects. Conclusion: Although findings pertaining to personal factors can inform practice, few studies explored the influence of environmental factors on occupational engagement. Given that occupation is a result of person-environment transactions, it is important that future research more fully explores environmental influences in order to enable occupational therapists to deliver services that optimize the occupational performance of seniors with ARVL.
BRCA1 and BRCA2 Gene Mutations Screening In Sporadic Breast Cancer Patients In Kazakhstan.
Authors: Akilzhanova Ainur R. , Nyshanbekkyzy Bagdat , Nurkina Zhannur M. , Shtephanov Ivan I. , Makishev Abay K. , Adylkhanov Tasbolat A. , Rakhypbekov Tolebay K. , Ramanculov Erlan M. , Momynaliev Kuvat T. 
Published: May 2013

Background: A large number of distinct mutations in the BRCA1 and BRCA2 genes have been reported worldwide, but little is known regarding the role of these inherited susceptibility genes in breast cancer risk among Kazakhstan women.Aim: To evaluate the role of BRCA1/2 mutations in Kazakhstan women presenting with sporadic breast cancer.Methods: We investigated the distribution and nature of polymorphisms in BRCA1 and BRCA2 entire coding regions in 156 Kazakhstan sporadic breast cancer cases and 112 age-matched controls using automatic direct sequencing.Results: We identified 22 distinct variants, including 16 missense mutations and 6 polymorphisms in BRCA1/2 genes. In BRCA1, 9 missense mutations and 3 synonymous polymorphisms were observed. In BRCA2, 7 missense mutations and 3 polymorphisms were detected. There was a higher prevalence of observed mutations in Caucasian breast cancer cases compared to Asian cases (p<0.05); higher frequencies of sequence variants were observed in Asian controls. No recurrent or founder mutations were observed in BRCA1/2 genes. There were no statistically significant differences in age at diagnosis, tumor histology, size of tumor, and lymph node involvement between women with breast cancer with or without the BRCA sequence alterations.Conclusions:Considering the majority of breast cancer cases are sporadic, the present study will be helpful in the evaluation of the need for the genetic screening of BRCA1/2 mutations and reliable genetic counseling for Kazakhstan sporadic breast cancer patients. Evaluation of common polymorphisms and mutations and breast cancer risk in families with genetic predisposition to breast cancer is ongoing in another current investigation.
Radiation Induced Decoloration of Reactive Dye in PVA Films for Film Dosimetry
Authors: Shaheen Akhtar  , Taqmeem Hussain  , Aamir Shahzad  , Qamar-ul-Islam  , Muhammad Yousuf Hussain  , Nasim Akhtar  
Published: May 2013

The investigation of film dosimeters made from polyvinyl alcohol (PVA) films dyed with methyl orange (MO) to enable their use in high dose radiation processing applications was studied. The dosimetric change in these films at pre and post irradiation was studied spectrophotometrically. Radiolytic bleaching was observed in PVA aided films exposed with Cs137 γ-source in dose range of 100-200kGy. The effects of pH, dye concentration and film thickness on the radiation response of the film dosimeters were discussed. The stability of MO-PVA films before and after exposure of radiation was also examined at ambient temperature and was found to be higher for long times at pre and post irradiation stages.
Dantin et l’âge de la métacritique
Authors: Lacroix Michel 
Published: May 2013

Avec le foisonnement de recueils d’essais critiques, entre 1928 et 1937, un retournement du commentaire littéraire sur lui-même s’opère, qui entraîne une remise en question de la critique et de ses fondements. L’analyse de cette « métacritique » effectuée dans cet article met en lumière le conflit entre trois logiques distinctes, trois « modèles » de critique et de socialisation : ceux de l’École, des médias et des réseaux. Or, un des acteurs clés de ce tournant critique, du passage vers la contestation des maîtres, fut Louis Dantin. Par sa trajectoire, son rapport aux oeuvres et sa correspondance, ce dernier incarna alors, pour plusieurs de ses pairs, l’idéal d’une amitié critique, exigeante et franche.
Indirect adaptive fuzzy control for input and output constrained nonlinear systems using a barrier Lyapunov function
Authors: Li Yongming , Li Tieshan , Jing Xingjian 
Published: May 2013

SUMMARYIn this paper, a novel indirect adaptive fuzzy controller is proposed for a class of uncertain nonlinear systems with input and output constrains. To address output and input constraints, a barrier Lyapunov function and an auxiliary design system are employed, respectively. The proposed approach is explored by employing fuzzy logic systems to tackle unknown nonlinear functions and combining the adaptive backstepping technique with adaptive fuzzy control design. Especially, the number of the online learning parameters are reduced to 2n in the closed‐loop system. It is proved that the proposed control approach can guarantee that all the signals in the closed‐loop system are bounded, and the input and output constraints are circumvented simultaneously. A numerical example with comparisons is provided to illustrate the effectiveness of the proposed approach. Copyright © 2013 John Wiley & Sons, Ltd.
Two cases of hepatic adenomas in patients with wolf‐hirschhorn syndrome: A new rare complication?
Authors: Prunotto Giulia , Cianci Paola , Cereda Anna , Scatigno Agnese , Fossati Chiara , Maitz Silvia , Biondi Andrea , Selicorni Angelo 
Published: May 2013

AbstractWolf–Hirschhorn syndrome (WHS) is a rare microdeletion syndrome associated with a characteristic facial appearance, failure to thrive, psychomotor delays, and various major malformations of internal organs; many medical complications have been described (feeding difficulties, epilepsy, hearing problems). Benign or malignant oncologic problems are not a typical feature of the natural history of these patients. We report on two patients with WHS patients in whom hepatic adenoma (HA) were diagnosed during adolescence. The clinical evolution of liver involvement was different between the two. We discuss the possibility of considering HA as a rare medical problem in the follow‐up of WHS patients. © 2013 Wiley Periodicals, Inc.
“If it helps …” the use of microarray technology in prenatal testing: Patient and partners reflections
Authors: Hillman Sarah C. , Skelton John , Quinlan‐Jones Elizabeth , Wilson Amie , Kilby Mark D. 
Published: May 2013

AbstractThe objective was to gain insight into the experiences of women and their partners diagnosed with a fetal abnormality on prenatal ultrasound examination and receiving genetic testing including microarray. Twenty‐five semi‐structured interviews were performed with women +/− their partners after receiving the results of prenatal genetic testing. Framework analysis was performed to elicit themes and subthemes. Five main themes were recognized; diagnosis, genetic testing, family and support, reflections of the treatment received and emotions. Our results showed that women recall being told about QFPCR for trisomy 13, 18, and 21 but often no further testing. Women expected the conventional karyotype and microarray result would be normal following a normal QFPCR result. There were frequent misconceptions by couples regarding aspects of counseling/testing. Communication of variants of unknown (clinical) significance (VOUS) presents a particularly difficult challenge. Good clear communication by health care professionals is paramount. When counseling women and their partners for fetal chromosomal testing it should be reinforced that although the most common, trisomy 13, 18, and 21 only account for some of the chromosomal changes resulting in abnormal scan findings. Couples should have literature to take home summarizing scan anomalies and reinforcing information about genetic testing. © 2013 Wiley Periodicals, Inc.
Neuroimaging predictors of brain amyloidosis in mild cognitive impairment
Authors: Tosun Duygu , Joshi Sarang , Weiner Michael W. 
Published: May 2013

ObjectiveTo identify a neuroimaging signature predictive of brain amyloidosis as a screening tool to identify individuals with mild cognitive impairment (MCI) that are most likely to have high levels of brain amyloidosis or to be amyloid‐free.MethodsThe prediction model cohort included 62 MCI subjects screened with structural magnetic resonance imaging (MRI) and 11C‐labeled Pittsburgh compound B positron emission tomography (PET). We identified an anatomical shape variation‐based neuroimaging predictor of brain amyloidosis and defined a structural MRI‐based brain amyloidosis score (sMRI‐BAS). Amyloid beta positivity (Aβ+) predictive power of sMRI‐BAS was validated on an independent cohort of 153 MCI patients with cerebrospinal fluid Aβ1–42 biomarker data but no amyloid PET scans. We compared the Aβ+ predictive power of sMRI‐BAS to those of apolipoprotein E (ApoE) genotype and hippocampal volume, the 2 most relevant candidate biomarkers for the prediction of brain amyloidosis.ResultsAnatomical shape variations predictive of brain amyloidosis in MCI embraced a characteristic spatial pattern known for high vulnerability to Alzheimer disease pathology, including the medial temporal lobe, temporal–parietal association cortices, posterior cingulate, precuneus, hippocampus, amygdala, caudate, and fornix/stria terminals. Aβ+ prediction performance of sMRI‐BAS and ApoE genotype jointly was significantly better than the performance of each predictor separately (area under the curve [AUC] = 0.88 vs AUC = 0.70 and AUC = 0.81, respectively) with >90% sensitivity and specificity at 20% false‐positive rate and false‐negative rate thresholds. Performance of hippocampal volume as an independent predictor of brain amyloidosis in MCI was only marginally better than random chance (AUC = 0.56).InterpretationAs one of the first attempts to use an imaging technique that does not require amyloid‐specific radioligands for identification of individuals with brain amyloidosis, our findings could lead to development of multidisciplinary/multimodality brain amyloidosis biomarkers that are reliable, minimally invasive, and widely available. Ann Neurol 2013;74:188–198
Are patterns of cortical hyperexcitability altered in catamenial epilepsy?
Authors: Badawy Radwa A. B. , Vogrin Simon J. , Lai Alan , Cook Mark J. 
Published: May 2013

ObjectiveWe used transcranial magnetic stimulation to determine menstrual cycle‐related changes in cortical excitability in women with and without catamenial epilepsy and investigated whether these changes differed between ovulatory and anovulatory cohorts.MethodsHealthy nonepilepsy women and women with generalized and focal epilepsy were investigated during ovulatory (n = 11, 46, and 43, respectively) and anovulatory (n = 9, 42, and 41) cycles. Patients were divided based on seizure pattern into catamenial (C1 = perimenstrual, C2 = periovulatory, C3 = luteal seizure exacerbation), noncatamenial, and seizure free. Cortical excitability was assessed using motor threshold (MT) and paired pulse stimulation at short (2–15 milliseconds) and long (100–300 milliseconds) interstimulus intervals twice, at the (1) late follicular and (2) mid luteal phases of the menstrual cycle.ResultsIn controls, cortical excitability was greatest in the follicular study, where intracortical facilitation was increased (p < 0.05). The opposite was seen in women with epilepsy, where intracortical facilitation was greatest and intracortical inhibition was least in the luteal studies (p < 0.05). There were no differences between the ovulatory and anovulatory groups in any of the cohorts. No changes were observed in MT.InterpretationNonhormonal factors are involved in the cyclicity of cortical excitability across the menstrual cycle. Normal menstrual cycle variations in cortical excitability are altered in a similar pattern in ovulatory and anovulatory women with epilepsy regardless of seizure patterns. The underlying neural changes associated with epilepsy may alter responses to sex hormones. This may be an important underlying mechanism for catamenial seizure clustering. Ann Neurol 2013;74:743–757
Is there a link between open‐angle glaucoma and dementia?
Authors: Helmer Catherine , Malet Florence , Rougier Marie‐Bénédicte , Schweitzer Cédric , Colin Joseph , Delyfer Marie‐Noëlle , Korobelnik Jean‐François , Barberger‐Gateau Pascale , Dartigues Jean‐François , Delcourt Cécile 
Published: May 2013

ObjectivePrevious research has suggested an association between dementia and glaucoma through common risk factors or mechanisms. Our aim was to evaluate the longitudinal relationship between open‐angle glaucoma (OAG) and incident dementia.MethodsThe Three‐City–Bordeaux–Alienor study is a population‐based cohort of 812 participants with a 3‐year follow‐up period. All participants were aged 72 years or older. An eye examination was performed on all subjects. An OAG was determined based on optic nerve damage and visual field loss. Incident dementia was actively screened for and confirmed by a neurologist.ResultsA total of 41 participants developed dementia over the 3‐year follow‐up period. Future incident dementia cases had an increased prevalence of OAG (17.5% vs 4.5% for nondemented participants, p = 0.003). After adjustment for age, gender, education, family history of glaucoma, vascular comorbidities, and apolipoprotein ε4, our results showed that participants with an OAG were four times more likely to develop dementia during the 3‐year follow‐up period (odds ratio = 3.9, 95% confidence interval = 1.5–10.4, p = 0.0054). An increased risk of dementia was also associated with 2 markers of optic nerve degeneration (vertical cup:disk ratio and minimal rim:disk ratio). However, no association was found between a high intraocular pressure and/or the use of intraocular pressure‐lowering medications and incident dementia.InterpretationIf the association between OAG and dementia is confirmed, direct and noninvasive quantification of the amount of retinal ganglion cell axonal loss may be a useful biomarker of cerebral axonal loss in the future. It may also offer new breakthroughs in understanding the underlying pathophysiological mechanisms of both diseases.