bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rare primary squamous cell carcinoma of the intrahepatic bile duct: A case report and review of literature
Authors: Ma Qing-Jun , Wang Fu-Hai , Yang Ning-Ning , Wei Hong-Long , Liu Feng 
Published: July 2024

BACKGROUND
Cholangiocarcinoma is the most common malignancy of the biliary tree and has a poor prognosis. Adenocarcinoma is the most common pathological type of cholangiocarcinomas, but rare squamous, adenosquamous, and mucinous variants have been reported without adequate clinical data.
CASE SUMMARY
This report describes a rare case of primary squamous cell carcinoma (SCC) of the intrahepatic bile duct. The patient was admitted with a tumor in the hepatic caudate lobe with no obvious clinical symptoms. Examination revealed hepatitis B surface antigen positivity, a slight increase in alfa-fetoprotein to 16.34 ng/mL, and an irregular slightly heterogeneous enhancing lesion in the hepatic caudate lobe, which was initially thought to be hepatocellular carcinoma. Laparoscopic resection was performed, and the final pathology suggested a rare primary SCC of the intrahepatic bile duct. Immunohistochemistry indicated positivity for villin, partial positivity for p63, and negativity for hepatocyte, CK7, CK8, CK19, and CK20. The Ki-67 index was approximately 60%. The patient received six cycles of Tegio chemotherapy. A new lesion was detected in the liver after 15 months. The surgery was performed, and the patient was followed-up at a local hospital. To date, no new lesions have been observed.
CONCLUSION
Surgery is the first choice for resectable lesions, and combined chemotherapy based on pathology is essential for increasing overall survival.
Concomitant epidermal growth factor receptor mutation/c-ros oncogene 1 rearrangement in non-small cell lung cancer: A case report
Authors: Peng Gui-Qin , Song Hai-Chi , Chen Wan-Yi 
Published: July 2024

BACKGROUND
Epidermal growth factor receptor (EGFR ) mutation and c-ros oncogene 1 (ROS1 ) rearrangement are key genetic alterations and predictive tumor markers for non-small cell lung cancer (NSCLC) and are typically considered to be mutually exclusive. EGFR/ROS1 co-mutation is a rare event, and the standard treatment approach for such cases is still equivocal.
CASE SUMMARY
Herein, we report the case of a 64-year-old woman diagnosed with lung adenocarcinoma, with concomitant EGFR L858R mutation and ROS1 rearrangement. The patient received two cycles of chemotherapy after surgery, but the disease progressed. Following 1-month treatment with gefitinib, the disease progressed again. However, after switching to crizotinib, the lesion became stable. Currently, crizotinib has been administered for over 53 months with a remarkable treatment effect.
CONCLUSION
The efficacy of EGFR tyrosine kinase inhibitors and crizotinib was vastly different in this NSCLC patient with EGFR /ROS1 co-mutation. This report will aid future treatment of such patients.
Penerapan Media Video Interaktif pada Pembelajaran Matematika untuk Meningkatkan Hasil Belajar Siswa Materi Pecahan Kelas V SD
Authors: Octaviani Emy Masfufah , Humairah Humairah , Khasanah Linaria Arofatul Ilmi Uswatun 
Published: July 2024

Perkembangan teknologi mengalami kemajuan yang sangat pesat saat ini. Dengan latar belakang era digital dan globalisasi, pendidikan harus senantiasa beradaptasi dengan perkembangan teknologi. Guru dapat menggunakan sumber daya pendidikan pada kegiatan pembelajaran, akan tetapi banyak guru tidak menindak lanjuti sehingga tetap menerapkan metode ceramah yang mengakibatkan murid cenderung tidak memperhatikan guru pada saat kegiatan belajar. Penelitian ini dilakukan untuk mengamati bagaimana guru dan siswa berinteraksi serta mengetahui peningkatkan hasil belajar pada pendidikan matematika dengan media video interaktif. Siklus I dan II dari penelitian tindakan kelas (PTK) ini terdiri dari perencanaan, pelaksanaan, observasi, dan refleksi. Kesimpulannya adalah bahwa: (1) Guru melihat aktivitas siswa pada siklus I rata-rata 54,16% dan siklus II 88,54%, peningkatan siklus I dan II 34,8%; (2) Siswa melihat aktivitas guru pada siklus I rata-rata 48% dan siklus II 84%, peningkatan siklus I dan II 36%; dan (3) Hasil belajar siswa pada siklus I rata-rata 48% dan siklus II 84%, peningkatan siklus I dan II 36%.
“Can we not do group stuff?”: Student insights on implementing co-creation in online intensive programs
Authors: Newell Samantha J. , Van Antwerpen Natasha 
Published: July 2024

The demand for intensive educational experiences is increasing, necessitating a focus on ensuring quality and providing adequate student support. Increasing opportunities for student collaboration, including teacher/student co-creation of learning materials, has strong potential to increase engagement and support. Given increased interest in co-creation within education and research more broadly, we explored student perspectives on this novel approach within online intensive modes of teaching with a focus on feasibility and implementation. Two focus groups were conducted with students (N = 16), including discussion of their preferences and barriers for implementing co-creation initiatives in an intensive program. Thematic analysis was then conducted, generating five themes. Students see co-creation as beneficial for self-development and connections (Theme 1), but also identify barriers such as its perception as another group assignment (Theme 2). Students believe successful co-creation requires a “type” of student who is intrinsically motivated and career-driven (Theme 3). Concerns exist about co-creation being an additional workload, emphasising the need for clear roles (Theme 4). Students’ views on co-creation vary, with differing opinions on its practicality (Theme 5). The findings suggest that successful implementation of co-creation initiatives requires careful consideration of barriers while addressing student concerns and leveraging their intrinsic motivation. For educators in intensive programs, it is crucial to provide incentives, collaborate on feasible time slots, establish clear objectives and timelines, offer guidance and support, and celebrate student achievements to effectively incorporate co-creation activities. By understanding students’ perceptions and preferences, educators can better support student collaboration, which is crucial for students’ development in intensive programs.
Striking for Victory
Authors: Woolum Janet 
Published: July 2024

Abstract
By the 1940s, the Women's International Bowling Congress (WIBC) was the largest sports membership organization for women in the world. At the advent of World War II, the WIBC implemented a nationwide fundraising campaign to support the war effort resulting in the direct purchase of a bomber, an ambulance, and three air evacuation planes for the US Armed Forces. The WIBC war effort unified, engaged, and connected more than two hundred thousand members to a common cause, while contributing to a significant growth in women's organized bowling nationwide. The effort helped usher in the “modern era” of women's organized bowling. Through it all, the WIBC emerged a more cohesive, stable group of state and local affiliations. The story of how WIBC leadership marshaled resources to contribute to the war effort while continuing their commitment to membership growth in wartime is important for the value it adds to the history of women's sports.
The Sun Rises on Coney Island
Authors: Bigalke Zachary R. 
Published: July 2024

Abstract
Japanese competitive eaters first arrived at the Nathan's Famous Hot Dog Eating Contest held annually on July 4 at Coney Island, New York, in the late 1990s, transforming the event from a local curiosity into a modern sport in the process. From 1997 to 2006, Hirofumi Nakajima, Kazutoyo Arai, Takeru Kobayashi, and other Japanese eaters redefined the quest for records in competitive eating and introduced new training and competition techniques to their American counterparts. By leaning into jingoistic rhetoric to market a series of regional qualifiers and form the International Federation of Competitive Eating, Nathan's organizers used the Japanese as a foreign rival around which to construct and expand the sport's bureaucracy. Japanese intervention at Coney Island catalyzed the popularity of competitive eating and sparked processes of sportification that transformed the Nathan's Hot Dog Eating Contest from a boardwalk sideshow into a global spectacle.
O‘ZBEKISTONNING XALQARO PISA TESTIDAGI NATIJALARI VA UNDAN TA’LIM TIZIMI SAMARADORLIGINI RIVOJLANTIRISHDA FOYDALANISH MASALALARI
Authors: Jumanova Shaxnozaxon , Odilova Maxliyoxon 
Published: July 2024

Ushbu maqola O‘zbekistonning xalqaro PISA testidagi natijalarini o‘rganishga qaratilgan, unda yoritilgan muammolarni tahlil qiladi va yanada mustahkam va global miqyosda raqobatbardosh ta’lim tizmini yaratish uchun ko‘plab natijalardan foydalanish strategiyalarini taklif qiladi. O‘zbekiston bo‘yicha PISA ko‘rsatkichlari e’tibor talab qiladigan bir qancha muhim masalalarga oydinlik kiritadi. O‘zbekistonning PISA maydonidagi debyuti uning ta’lim natijalari va OECD mamlakatlari natijalari o‘rtasidagi sezilarli tafovutni ko‘rsatdi. Shuningdek O‘zbekiston 2022-yilda ilk bora PISA testida ishtirok etdi. Bu natijalardan foydalanib O‘zbekiston Ta’lim tizimidagi o‘zining kamchiliklarini o‘rganishi va boshqa yuqori natijalarni egallagan davlatlar tajribalaridan foydalanishi mumkin. Maqolani yozish davomida PISA testining OECD mamlakatlari o‘rtacha ko‘rsatkichlari va O‘zbekiston natijalari o‘zaro taqqoslangan. Bu orqali natijalar qismida jadvallar va grafiklar orqali batafsil tanishishingiz mumkin. Maqolaning so‘nggi qismida esa O‘zbekistoning ta’lim tizimi va yuqoridagi natijalardan foydalanib kelgusidagi PISA testlarida yaxshi natijalarga erishish uchun xulosalar berilgan.
AGRICULTURA REGENERATIVA COM BASE NA TIPOLOGIA DE ARGILA DO SOLO
Authors: Sant’Ana Amanda Luca , Siqueira Diego Silva , Silva Aparecida Leonir da 
Published: July 2024

O sucesso da produção de soja requer a adoção de manejos que sejam sustentáveis economicamente e ambientalmente, aliados a técnicas que permitam identificação de áreas com diferentes potenciais agrícolas promovendo uma maior eficiência do manejo do solo. Desta forma, práticas de agricultura regenerativa têm se destacado por sua capacidade de mitigar efeitos dos gases estufa, além de promover ganhos em produtividade. Assim, o objetivo deste estudo, foi criar indicadores para a agricultura regenerativa criando zonas de manejo com base no diagnóstico da tipologia de argila dos solos através da técnica de susceptibilidade magnética (SM). O trabalho foi realizado no município de Patrocínio Paulista - SP. A área de estudo de aproximadamente 140 hectares é cultivada com soja na safra principal e desde 2019 tem adotado práticas de agricultura regenerativa. Para realização do trabalho foram fornecidos dados legados da área e novas amostras foram coletadas em 11 pontos, para avaliação da tipologia de argila do solo via SM. Os resultados das análises foram eficientes na identificação de ambientes mais favoráveis à retenção de MO, formação de novos minerais pedogenéticos e na identificação de áreas mais responsivas aos manejos utilizados. Os maiores índices de produção e retenção de carbono por meio do acréscimo de MO ao solo, foram observados nos locais com valor de SM elevado.Isto sugere que a criação de zonas de manejo específico com base na tipologia de argila, promoveram a identificação de áreas com diferentes potenciais de resposta para armazenamento de carbono no solo e agricultura regenerativa.
PENGARUH JALAN PAGI TERHADAP PERUBAHAN TEKANAN DARAH PADA LANSIA DENGAN HIPERTENSI DI PANTI SOSIAL TRESNA WERDA SABAI NAN ALUIH SICINCIN
Authors: Yupita Rina , Khairul Andre  , Siti Salmah  
Published: July 2024

ABSTRACT
Hypertension is a state of increased blood pressure beyond the normal limit. The number of people with hypertension continues to increase every year, it is estimated that in 2025 there will be 1.5 billion people affected by hypertension, and it is estimated that every year 9.4 million people die from hypertension and its complications. Increased physical activity in the form of exercise or regular physical exercise can reduce blood pressure to normal levels and reduce the risk of hypertension attack by 50%.This research is a quantitative quasi-experimental study (quasy experiment) pre-post test with control group design that aims to see and compare interventions carried out before and after treatment in the form of a morning walk. This research was conducted from 25 August to 7 September 2019 with 20 respondents. Wilcoxon statistical test results obtained p value <0.05. Statistical test results obtained p-value = 0.003 which means the p-value <0.05, it can be concluded that there is an influence of blood pressure in the elderly who suffer from hypertension between the intervention group and the control group. It is hoped that the leaders of the Tresna Werda Sabai Orphanage Aluih Sicincin need to maintain a routine morning walk in reducing the risk of hypertension.
Keywords: Morning Walk, Hypertension`

ABSTRAK
Hipertensi adalah keadaan peningkatan tekanan darah melebihi batas normal. Jumlah penyandang hipertensi terus meningkat setiap tahunnya, diperkirakan pada tahun 2025 akan ada 1,5 Miliar orang yang terkena hipertensi, dan diperkirakan setiap tahunnya 9,4 juta orang meninggal akibat hipertensi dan komplikasinya. Peningkatan aktifitas fisik berupa olahraga atau latihan jasmani secara teratur dapat menurunkan tekanan darah ke tingkat normal dan menurunkan resiko serangan hipertensi 50%. Penelitian ini merupakan penelitian kuantitatif eksperimen semu (quasy experiment) rancangan pre-post test with control group yang bertujuan untuk melihat dan membandingkan intervensi yang dilakukan sebelum dan sesudah perlakuan berupa jalan pagi. Penelitian ini dilakukan tanggal 25 Agustus sampai 7 September 2019 dengan 20 responden. Hasil uji statisti wilcoxon didapatkan nilainya p<0.05. Hasil uji statistik diperoleh nilai p-value = 0,003 yang artinya nilai p-value <0,05 maka dapat disimpulkan ada pengaruh tekanan darah pada lansia yang menderita hipertensi antara kelompok intervensi dan kelompok kontrol. Diharapkan pimpinan Panti Tresna Werda Sabai Nan Aluih Sicincin perlu mempertahankan kegiatan rutin jalan pagi dalam menurukan resiko terjadinya hipertensi.
Kata Kunci: Jalan Pagi, Hipertensi
Hubungan Ibu, Anak, dan Keluarga dengan Stunting Balita Usia 24-59 Bulan
Authors: Valentine Nindy Irsila Dwi , Prasetyowati Irma , Noveyani Adistha Eka 
Published: July 2024

Pendahuluan: Stunting masih menjadi masalah gizi yang banyak terjadi pada balita. Karakteristik ibu perlu diperhatikan karena berpengaruh terhadap proses pertumbuhan janin. Karakteristik anak juga merupakan faktor risiko stunting, juga karakteristik keluarga karena penyebab dasar stunting juga terletak pada level keluarga. Tujuan penelitian ini adalah menganalisis hubungan antara karakteristik ibu, anak, dan keluarga dengan kejadian stunting pada balita usia 24-59 bulan. Metode: Penelitian analitik yang menggunakan rancangan studi observasional dengan desain penelitian case control. Besar sampel 40 sampel kasus dan 40 sampel kontrol menggunakan teknik simple random sampling. Hasil: Terdapat hubungan antara usia ibu saat hamil, pendidikan ibu, berat badan dan panjang badan lahir anak, status pemberian ASI eksklusif, jumlah anggota keluarga, dan pendapatan keluarga dengan stunting. Tidak terdapat hubungan antara jarak kehamilan dan pekerjaan ibu dengan kejadian stunting. Saran: evaluasi setelah edukasi, melakukan pemantauan dan tindak lanjut terkait pemenuhan nutrisi ibu hamil, menghilangkan kebiasaan atau budaya terkait pencampuran makanan halus untuk anak sebelum 6 bulan, aktif melakukan konseling gizi terkait cara pemenuhan gizi anak dengan menggunakan bahan makanan bergizi yang murah dan sederhana serta konseling terkait pengelolaan dan pendistribusian makanan bergizi yang baik di dalam keluarga yang tergolong keluarga besar.
AUDIO THERAPY BASED ON MINDFULLNESS (AdEMs) AGAINST THE ANXIETY OF ELECTIVE SURGERY PREOPERATION PATIENTS
Authors: Nurul Hidayah , Putri Novita Surya , Syakura Abdan 
Published: July 2024

Pendahuluan: Tindakan operasi merupakan tatalaksana yang dilakukan dibawah pengaruh anestesi atau pembiusan dan menjadi faktor penyebab kecemasan pada pasien. Ruang bedah elektif digunakan untuk merawat pasien yang direncanakan mendapatkan terapi pembedahan. Masalah keperawatan yang ditemukan pada pasien di ruang bedah elektif yaitu kecemasan dan nyeri. Waktu tunggu operasi bisa memanjang dikarenakan pasien harus menjalani pemeriksaan dan dalam keadaan stabil. Mindfulness merupakan latihan menyadari kondisi yang dialami tubuh, pikiran, perasaan, situasi saat ini dan berpikir secara sadar untuk membuat perasaan atau situasi yang tenang, meningkatkan kesehatan dan kesejahteraan melalui pemahaman pengalaman antara pikiran, tubuh, dan emosi. Tujuan: Mengetahui pengaruh pemberian audio terapi berbasis mindfullnes theraphy terhadap kecemasan pasien preoperasi di Ruang Bedah Elektif. Metode: Desain pra experiment dengan pendekatan one-group pra-post test design. Populasi seluruh pasien dewasa di ruang Bedah elektif yang menunggu operasi. Sample pasien dewasa di ruang Bedah elektif yang akan menjalani operasi sesuai kriteria inklusi dan eksklusi berjumlah 7 pasien. Menggunakan Accidental sampling, pada Pre-Post Test, Instrumen yang digunakan adalah kuisioner pengukuran ansietas HADS (Hospital Anxiety and Depression Scale) dan NOC (nursing outcome classification). Intervensi AdEMs (Audio terapi berbasis Mindfulness) diberikan selama 1 minggu. Hasil: Ada pengaruh audio terapi berbasis mindfulness (AdEMs) terhadap ansietas pasien pre operasi, nilai p<0,05 dengan nilai signifikansi p=0,014. Pembahasan: Kecemasan ditandai dengan rasa takut, tidak menyenangkan, disertai dengan gejala seperti nyeri kepala, berkeringat, palpitasi dan gelisah. Audio terapi berbasis Mindfullnes mengatasi kecemasan, mengurangi durasi perawatan di rumah sakit, meningkatkan kepuasan, meminimalkan komplikasi pascaoperasi dan meningkatkan kesejahteraan psikologis pasien. Kesimpulan: audio terapi berbasis Mindfulness meningkatkan kemampuan untuk mengasimilasi informasi dan menurunkan tingkat kecemasan dengan penerimaan diri yang baik.
GAMBARAN PENGETAHUAN & SIKAP PERAWAT TENTANG PENGGUNAAN TRIAGE DI IGD RS TIPE B KOTA MALANG
Authors: Indri Wahyuningsih  , Angelita Putri Wafa Pradita  
Published: July 2024

Introduction: Instalasi Gawat Darurat (IGD) adalah tempat stasioner pertama yang dapat digunakan pasien atau keluarganya untuk mendapatkan pertolongan pertama yang cepat, akurat, dan menyeluruh untuk semua hal. Proses pengambilan keputusan dimana pasien berisiko kematian, kecacatan, kemunduran klinis dan pasien aman untuk menunggu disebut dengan triage.
Objectives: Mengidentifikasi pengetahuan dan sikap perawat tentang penggunaan triase di IGD.
Methods: Menggunakan pendekatan kuantitatif deskriptif. instrument yang digunakan berupa kuesioner dengan bantuan analisa dari SPSS 25 dengan responden berjumlah 30. Prosedur penelitian menggunakan pembagian kuesioner kepada perawat di IGD untuk menganalisa Gambaran Pengetahuan dan Sikap Perawat tentang Penggunaan Triage di IGD.
Results: Proporsi perawat berjenis kelamin laki-laki sebanyak 19 orang (63,3%) lebih banyak dari pada perempuan. Proporsi perawat paling banyak usia 26-35 tahun sebanyak 26 orang (86,7%) dengan pendidikan terakhir paling banyak s1 sebanyak 26 orang (86,7%) dengan lama kerja paling banyak 5-10 tahun sebanyak 13 orang (43,3%). Proporsi pengetahuan tinggi sebanyak 22 orang (73,3%) dan pravelensi sikap perawat positif sebanyak 27 orang (90%).
Conclusions: Penelitian ini menunjukkan bahwa perawat di IGD memiliki tingkat pengetahuan dan sikap perawat yang tinggi. Dibuktikan dengan lama kerja dan pendidikan terakhir yang mempengaruhi hasil dari tingkat pengetahuan dan sikap perawat tersebut.
ON THE QUESTION OF THE CONCEPT OF MARTIAL LAW
Authors: Туркина Н.Ю. 
Published: July 2024

В статье автор исследует сложный и многоуровневый институт военного положения, сопоставляет нынешнее законодательное закрепление понятия военного положения с научными подходами к его определению. Проводит ретроспективный анализ понятий военного положения, выделяет признаки, присущие военному положению. Анализ проводится через призму конституционных норм и федеральных законов, регулирующих действие особых правовых режимов. Материалы и методы.Основу исследования составили нормы действующего российского законодательства и научные труды в области военного положения и особых правовых режимов. В работе использовались диалектический метод научного познания, который характеризуется универсальностью и служит методологической базой, методы логической дедукции и индукции, позволяющие выводить частные закономерности. Применялись познавательные методы сравнения, анализа, обобщения и описания, обеспечивающие всестороннее и объективное изучение материала. Результаты исследованияпозволили сформировать предложения, направленные на совершенствование законодательства в области военного положения. Было выявлено, что существующее законодательство не в полной мере соответствует современным требованиям и нуждается в актуализации. Выводы и заключения. С целью формирования единого подхода к пониманию военного положения и полного отражения его сущности выделены основные его признаки и предложено авторское определение военного положения.
in the article, the author explores the complex and multilevel institution of martial law, compares the current legislative consolidation of the concept of martial law with scientific approaches to its definition. Conducts a retrospective analysis of the concepts of martial law, identifies the signs inherent in martial law. The analysis is carried out through the prism of constitutional norms and federal laws governing the operation of special legal regimes. Materials and Methods:the research was based on the norms of current Russian legislation and scientific works in the field of martial law and special legal regimes. The research is based on the dialectical method of scientific cognition, which is characterized by universality and serves as a methodological basis. Methods of logical deduction and induction were also used to deduce particular patterns. Cognitive methods of comparison, analysis, generalization and description were also used, providing a comprehensive and objective study of the material. The Results of the Studymade it possible to formulate proposals aimed at improving legislation in the field of martial law. It was revealed that the existing legislation does not fully meet modern requirements and needs to be updated. Findings and Conclusions:in order to form a unified approach to understanding martial law and fully reflect its essence, the main features are highlighted and the author's definition of martial law is proposed.