bluuebunny/crossref_metadata_2025_split huggingface dataset:
IFNγ modulates human immunoglobulin receptor expression in lipoaspirate-derived mesenchymal stem cells
Authors: Laksmitawati Dian R. , Pawitan Jeanne A. , Sadikin Mohamad , Sardjono Caroline T. , Utomo Ahmad R. 
Published: October 2014

Background: Mesenchymal stem cell (MSC) has been reported to have immunomodulator capacity against autoimmune diseases and to prevent allogenic tissue rejection. Many studies revealed that MSC’s inhibit T cell proliferation and induce immunosuppressive condition through the production of prostaglandins, and interleukin-10. In addition, MSC was reported to reduce circulating autoantibody in autoimmune patients following MSC transfusion. So far, there has been no report stating the presence of Fc receptors (receptors for immunoglobulin) on MSCs. The aim of this study was to reveal the expression of FcγRs in lipoaspirate-derived MSCs by measuring transcription of FcγR mRNA and whether the expression can be modulated.Methods: Lipoaspirate-derived MSCs were cultured in suitable medium and confirmed to be MSCs according to the criteria published by International Society for Cellular Therapy. Total mRNA of MSCs was isolated, and detection of human FcγRI, FcγRIIA and FcγRIIB mRNA was performed. Further, modulation of the expression was tested using heat aggregated gamma globulin (HAGG) and interferon (IFN)γ.Results: FcγRs mRNA was detected in the first passage of MSCs. However, the expression was no longer present after more than 4 passages. Further, increased level of FcγRI and FcγRIIA mRNA expression was detected with the addition of IFNγ in the culture. This preliminary finding opens a new insight for the understanding of interaction between MSCs and immunoglobulin G through FcγRs.Conclusion: Lipoaspirate-derived MSCs express FcγRs, and the expression is modulated by IFNγ.
Excavating evidence from experience
Authors: Byrne Libby 
Published: October 2014

Abstract
This article addresses the challenge of excavating the evidence from our lived experience with arts and health, describing the impact of direct personal experience with art making on health, and of an inter-subjective aesthetic experience. This material, derived from a studio practice of painting that explored the experience of multiple sclerosis (MS), was presented as a case story at the Evidence in a Different Form Conference in 2013, and the kinds of evidence noted by the group are reported.
Producing the evidence we need and validating the evidence we have
Authors: Robinson Priscilla , Daly Jeanne 
Published: October 2014

Abstract
If health policy-makers are to fund arts/health programmes, they need evidence that there is a benefit. For some, the best research evidence is to be derived from blinded clinical trials that have been synthesized into a systematic review. Clearly, however, there are questions which cannot be answered with clinical trials. In this article we discuss how high-quality evidence can be derived from many kinds of research. Clinical trials are useful in some settings but we need to know about the full range of research methods in the emerging field of arts and public health. Researchers can use their own specialist knowledge and forge research collaborations to strengthen the use of arts-based methods for evidence for health improvement at a population level.
The Internet as Teacher
Authors: Thorgersen Ketil , Zandén Olle 
Published: October 2014

Abstract
Social media has led to new opportunities for learning music. In less formalized settings, a whole new arena for learning music has developed. The aim of this article is to investigate student teachers’ experiences of learning to play an instrument with the Internet as a teacher. The investigation was done as an action research study where twelve beginning teacher-training students were given the task to use the Internet to learn how to play an instrument. The students were organized in peer groups to help each other. Documentation of the progress happened through logbooks. The project lasted for half a year in 2011 and had a triple intention: to provide the students with experience about learning how to play by help of the Internet, for the students to learn to play a second instrument, and to investigate if and how learning practices for learning an instrument aided by the Internet could be useful in music teacher training.
An Ostrowski type inequality for derivatives of q-th power of s-convex functions via fractional integrals
Authors: Özdemir Muhamet Emin , Yildiz Çetin 
Published: October 2014

Abstract
In this paper, we establish several new inequalities for s-convex mappings
that are connected with the Riemann–Liouville fractional integrals. Our
results have some relationships with an Ostrowski type integral inequality in
the literature.
Lewisian Time Travel in a Relativistic Setting
Authors: Daniels Paul R. 
Published: October 2014

Abstract
I argue that David Lewis’s philosophically dominant conception of time travel cannot straightforwardly handle what we might call cases of relativistic time travel – that is, the sort of time travel which could only plausibly occur in a relativistic setting. I evaluate whether or not the Lewisian account can be successfully adapted such that it would able to analyse potential cases of relativistic time travel satisfactorily while still being employable in the analysis of those cases that make no mention of physics or the structure of spacetime. This is primarily an analytical and explanatory exercise, rather than a polemical one.
Must Naturalism Lead to a Deflationary Meta-Ontology?
Authors: Haug Matthew 
Published: October 2014

AbstractHuw Price has argued that naturalistic philosophy inevitably leads to a deflationary approach to ontological questions. In this paper, I rebut these arguments. A more substantive, less language-focused approach to metaphysics remains open to naturalists. However, rebutting one of Price’s main arguments requires rejecting Quine’s criterion of ontological commitment. So, even though Price’s argument is unsound, it reveals that naturalists cannot rest content with broadly Quinean, “mainstream metaphysics,” which, I suggest, naturalists also have independent reasons to reject.
Combined deletion of Pten and p53 in mammary epithelium accelerates triple‐negative breast cancer with dependency on eEF2K
Authors: Liu Jeff C , Voisin Veronique , Wang Sharon , Wang Dong‐Yu , Jones Robert A , Datti Alessandro , Uehling David , Al‐awar Rima , Egan Sean E , Bader Gary D , Tsao Ming , Mak Tak W , Zacksenhaus Eldad 
Published: October 2014

AbstractThe tumor suppressors Pten and p53 are frequently lost in breast cancer, yet the consequences of their combined inactivation are poorly understood. Here, we show that mammary‐specific deletion of Pten via WAP‐Cre, which targets alveolar progenitors, induced tumors with shortened latency compared to those induced by MMTV‐Cre, which targets basal/luminal progenitors. Combined Pten‐p53 mutations accelerated formation of claudin‐low, triple‐negative‐like breast cancer (TNBC) that exhibited hyper‐activated AKT signaling and more mesenchymal features relative to Pten or p53 single‐mutant tumors. Twenty‐four genes that were significantly and differentially expressed between WAP‐Cre:Pten/p53 and MMTV‐Cre:Pten/p53 tumors predicted poor survival for claudin‐low patients. Kinome screens identified eukaryotic elongation factor‐2 kinase (eEF2K) inhibitors as more potent than PI3K/AKT/mTOR inhibitors on both mouse and human Pten/p53‐deficient TNBC cells. Sensitivity to eEF2K inhibition correlated with AKT pathway activity. eEF2K monotherapy suppressed growth of Pten/p53‐deficient TNBC xenografts in vivo and cooperated with doxorubicin to efficiently kill tumor cells in vitro. Our results identify a prognostic signature for claudin‐low patients and provide a rationale for using eEF2K inhibitors for treatment of TNBC with elevated AKT signaling.
Out-of-Hospital Medication Errors Among Young Children in the United States, 2002–2012
Authors: Smith Maxwell D. , Spiller Henry A. , Casavant Marcel J. , Chounthirath Thiphalak , Brophy Todd J. , Xiang Huiyun 
Published: October 2014

OBJECTIVE:
To investigate out-of-hospital medication errors among young children in the United States.

METHODS:
Using data from the National Poison Database System, a retrospective analysis of out-of-hospital medication errors among children &lt;6 years old from 2002 through 2012 was conducted.

RESULTS:
During 2002–2012, 696 937 children &lt;6 years experienced out-of-hospital medication errors, averaging 63 358 episodes per year, or 1 child every 8 minutes. The average annual rate of medication errors was 26.42 per 10 000 population. Cough and cold medication errors decreased significantly, whereas the number (42.9% increase) and rate (37.2% increase) of all other medication errors rose significantly during the 11-year study period. The number and rate of medication error events decreased with increasing child age, with children &lt;1 year accounting for 25.2% of episodes. Analgesics (25.2%) were most commonly involved in medication errors, followed by cough and cold preparations (24.6%). Ingestion accounted for 96.2% of events, and 27.0% of medication errors were attributed to inadvertently taking or being given medication twice. Most (93.5%) cases were managed outside of a health care facility; 4.4% were treated and released from a health care facility; 0.4% were admitted to a non–critical care unit; 0.3% were admitted to a critical care unit; and 25 children died.

CONCLUSIONS:
This is the first comprehensive study to evaluate the epidemiologic characteristics of out-of-hospital medication errors among children &lt;6 years of age on a national level. Increased efforts are needed to prevent medication errors, especially those involving non–cough and cold preparations, among young children.
Develop Electricity Projects and Transmission lines in a 'War Footing'
Authors: Thanju Jeewan Prasad 
Published: October 2014

Not available. DOI: http://dx.doi.org/10.3126/hn.v14i0.11243Hydro Nepal JournalJournal of Water, Energy and EnvironmentVol. 14, 2014, JanuaryPage:7-7
Sustainability of Bhutan's Hydropower
Authors: Chhopel Gongsar Karma 
Published: October 2014

Bhutan’s river potential for hydropower has been estimated at ~30,000 MW, the majority of which is concentrated in the Wangchhu, Punatsangchhu, Mangdechhu and Drangmechhu river basins. Hydropower forms the backbone of Bhutan’s socio-economic strength: Ninety nine percentage of its electricity supply comes from hydropower generation and hydropower alone contributes of national revenue. Bhutan has been cast as a model in South Asia for its environmental conservation policy. However, the impacts of climate change are becoming evident in the form of fast-retreating glaciers and erratic precipitation patterns that will prove to be costly for the hydropower sector as the country continues to bank on this renewable natural resource.DOI: http://dx.doi.org/10.3126/hn.v14i0.11272 HYDRO Nepal JournalJournal of Water, Energy and EnvironmentVolume: 14, 2014, JanuaryPage: 73-76
Les mots du sexe et leurs destins
Authors: Schneider Monique 
Published: October 2014

Alors que le terme sexual semble admis comme représentant, dans toutes les langues, de l’adjectif qui se rapporte à la sexualité, le texte du fondateur de la psychanalyse offre d’autres possibilités, parfois déroutantes. Les mots dérivant de racines latines – sexual, sexuell – voisinent avec des termes d’origine germanique, dont le plus fréquent est Geschlecht , qui signifie genre, lignée, sexe. Adjectivé, il devient geschlechtlich, terme abondamment présent dans le texte freudien. Une question principale : comment entendre l’insertion du terme schlecht – apparemment porteur d’un interdit, puisqu’il signifie « mauvais » – dans ce qui désigne le sexuel ? Dans la rencontre clinique avec Élisabeth, la nomination, par Freud, du mouvement amoureux qu’il attribue à la patiente est reçue par elle comme accusation de Schlechtigkeit (vilenie, méchanceté). L’association entre le geschlechtlich (sexuel) et le schlecht (mauvais) est présente dans la formule par laquelle, dans une lettre à Fliess, Freud associe la psychanalyse à schlechte Behandlung (mauvais traitement). À l’inverse, l’absence de suspicion culpabilisante présente dans le terme français « puissance », suspicion qui ferait planer un risque d’érotisme, a pour conséquence de désexualiser ce terme et de le réserver à ce qui concerne le champ social ou financier.
L'intraduisible entre les échos chaleureux et meurtriers d'une même langue
Authors: Altounian Janine 
Published: October 2014

Un voyage au pays meurtrier de ses parents rescapés du génocide arménien de 1915 amène l’auteur à expliquer comment le défi de traduire l’intraduisible a motivé son travail dans les deux champs de son activité de traductrice 1 – de Freud, 2 – de ce qui du silence des survivants aux meurtres de masse se transmet à leurs enfants. Pour recueillir et transmettre ce qui reste d’une culture détruite, il faut donc le traduire, tenter de traduire l’intraduisible. La pulsion à traduire naît d’une nécessité à défier paradoxalement l’impossibilité d’une traduction : soit celle à traduire un plaisir – pris à la langue étrangère ignorée de son lecteur ou procuré par l’amour secret des ascendants vécu naguère dans le mutisme –, soit celle à traduire une perte ou une douleur – la perte de la polysémie des mots lors du passage d’une langue-source à la langue-cible, ou la douleur partagée inconsciemment dans l’enfance avec ceux qui ont survécu à la perte de leur pays et de la foi en la vie.
La perte d'influence de la France sur la scène internationale
Authors: de La Sablière Jean-Marc 
Published: October 2014

La France a toujours de nombreux atouts. Elle reste une puissance qui compte malgré un affaiblissement de son poids et de son influence liés à la mondialisation et à l’émergence de nouvelles puissances. La crise économique et financière accélère cependant son déclin car la France a du mal à s’adapter. Sa perte de crédibilité récente en Europe est un signe inquiétant. Le déséquilibre du couple franco-allemand affecte sa capacité à bâtir une « Europe puissance ». Or celle-ci est indispensable pour l’avenir de la France et de l’Europe dans le monde. Le redressement est heureusement possible. Il faut aller au-delà des réformes actuellement prévues. Si ce chemin est pris, ce qui suppose que les Français soient rassemblés, la crédibilité de la France et sa capacité d’agir en Europe et à travers l’Europe seront très vite restaurées.
La grande guerre du côté des malgaches quelles perspectives pour des colonisés ?
Authors: Rajaonah Faranirina V. 
Published: October 2014

La grande majorité des 46 000 Malgaches, pour la plupart de modestes paysans, partirent au front sous la contrainte, avec cependant l’espoir de récompense. De fait, certains de ces indigènes revendiquèrent la citoyenneté au lendemain d’un conflit décidé par la France, mère Patrie de colonisés qui ont pu quelquefois avoir le sentiment de lutter plutôt pour leur « Terre des ancêtres » où 30 000 revinrent souvent déçus.
Bordeaux, capitale de la mobilisation industrielle (20 septembre 1914)
Authors: Bonin Hubert 
Published: October 2014

La mise en œuvre « plan Joffre » en été 1914 déçoit et le ministre de la Guerre Millerand en tire la leçon. Une histoire méconnue se situe à Bordeaux en septembre 1914, quand des experts (officiers supérieurs, patrons d’entreprise, ministre) mettent au point une stratégie de mobilisation industrielle qui constitue une rupture. Il faut reconstituer les causes de cette inflexion militaire, préciser les circonstances, déterminer le rôle joué par certains acteurs clés, et apprécier les effets plus ou moins rapides des choix effectués.
Forces françaises de l'Ouest, forces françaises oubliées ?
Authors: Weiss Stéphane 
Published: October 2014

Cet article analyse le paradoxal traitement mémoriel dont font l’objet les Forces françaises de l’Ouest, réunion des volontaires français engagés après septembre 1944 face aux poches allemandes maintenues sur la façade atlantique française : la mémoire collective de ces combattants s’est construite autour d’un sentiment d’oubli, illustré par l’ironique jeu de mots « Forces françaises de l’Ouest = Forces françaises oubliées » attesté dès l’hiver 1944-1945. Dans un premier temps, il est proposé d’étudier les conditions d’émergence de cette expression, entre enjeux militaires et représentations des combattants. Vient ensuite une analyse des conditions de transmission de cette expression jusqu’à nos jours, à travers l’historiographie relative à ces fronts secondaires.
La base de Séno, la France et l'Asie du Sud-Est (1953-1963)
Authors: Le Page Jean-Marc 
Published: October 2014

Séno au Laos est une base aéroterrestre mise en place en 1953 au moment où la guerre du Vietnam s’étend à l’Indochine. Après les accords de Genève de juillet 1954 elle devient le principal centre de renseignement français en Asie et une carte diplomatique majeure dans les mains du général de Gaulle. En 1963, la fermeture de la base française symbolise la fin de la présence militaire française en Asie et une nouvelle orientation de sa politique étrangère.
Ergonomie prospective et âge : proposition de méthodes nouvelles pour la conception d'un système de maintien à domicile
Authors: Moget Caroline , Bonnardel Nathalie , Galy Édith 
Published: October 2014

Cet article s’inscrit dans le cadre d’un projet de conception d’un artefact innovant de maintien à domicile à destination de personnes âgées : le projet MADO. Dans cette perspective, nous décrivons et analysons différentes méthodes qui nous semblent utiles pour ce projet de conception et nous présentons des études antérieures qui fournissent des suggestions intéressantes. Cette analyse a lieu en amont de la spécification des fonctions du futur artefact et relève donc du champ de l’ergonomie prospective. Elle nous permet de proposer une méthodologie adaptée au projet MADO. Nous prévoyons notamment de faire appel à la créativité des futurs utilisateurs pour faire émerger leurs besoins dans le cadre de réunions en petits groupes. Sur la base à la fois des méthodes et études antérieures présentées et de l’analyse des spécificités du projet MADO, nous proposons et discutons des recommandations pour les démarches et les méthodes en ergonomie prospective.
Is fine needle aspiration cytology a useful diagnostic tool for granular cell tumors? A cytohistological review with emphasis on pitfalls
Authors: Koshy Jason , Schnadig Vicki , Nawgiri Ranjana 
Published: October 2014

Background:
Granular cell tumors (GCT) formerly known as Abrikossoff tumor or granular cell myoblastoma, are rare neoplasms encountered in the fine needle aspiration (FNA) service. Named because of their highly granular cytoplasm which is invariably positive for the S-100 antibody, the classic GCT is thought to be of neural origin. The cytomorphological features range from highly cellular to scanty cellular smears with dispersed polygonal tumor cells. The cells have abundant eosinophilic granular cytoplasm, eccentric round to oval vesicular nuclei with small inconspicuous nucleoli. The fragility of the cells can result in many stripped nuclei in a granular background. The differential diagnosis occasionally can range from a benign or reactive process to features that are suspicious for malignancy. Some of the concerning cytologic features include necrosis, mitoses and nuclear pleomorphism.

Methods:
We identified 6 cases of suspected GCT on cytology within the last 10 years and compared them to their final histologic diagnoses.

Results:
Four had histologic correlation of GCT including one case that was suspicious for GCT on cytology and called atypical with features concerning for a malignant neoplasm. Of the other two cases where GCT was suspected, one showed breast tissue with fibrocystic changes, and the other was a Hurthle cell adenoma of the thyroid.

Conclusions:
These results imply that FNA has utility in the diagnosis of GCT, and should be included in the differential diagnoses when cells with abundant granular cytoplasm are seen on cytology. Careful attention to cytologic atypia, signs of reactive changes, use of immunohistochemistry, and clinical correlation are helpful in arriving at a definite diagnosis on FNA cytology.
A Critical Exploration of African Spirituality and Democracy in Africa
Authors: Igboin Benson O. 
Published: October 2014

Abstract
This article investigates the spiritual dimension of African politics, a significant, real, and practical variable that has received little recognition in public discourse about the practice of democracy in Africa. I focus on the role of African spiritual agency and its cosmological implications in the development of African democracy. The article argues that African spirituality is pervasive but not sufficiently strong to meet the challenges of new political realities. Through the use of critical case analysis, the study concludes that African politicians exhibit a dual loyalty, affirming Western political theories in public discourse (in most cases) while adhering to African spiritual rituals and oaths in private. The consequences of this include undermining the dividends of democracy and encouraging the dereliction of the environment.
Temazcal
Authors: Báez de Lacayo Laura 
Published: October 2014

"«…comer no es per se un acto del todo inocente, es decir, desprovisto de las relaciones sociales de los comensales. En este sentido, la colonialidad en todas sus formas (del poder, del saber y del ser) está presente como dispositivo tanto de enunciación como de clasificación alimentaria. Si nuestra historia está signada por una taxonomía de lo social, que en el proceso de conquista/colonia jerarquizó a los grupos humanos por el color de la piel, también es posible develar que se dio una suerte de suplantación gastronómica…»Adolfo Albán Achinte, Universidad de Cauca, Doctor en Estudios Culturales Latinoamericanos de la Universidad Andina Simón Bolívar (Quito).DOI: http://dx.doi.org/10.5377/cultura.v20i62.1469 Cultura de Paz Vol.20 No.62 2014; 20
LA REFLEXION PREVENTIVE DE HABERMAS SUR LA TECHNIQUE GENETIQUE
Authors: Mbulu Henri 
Published: October 2014

O artigo procura reformar a argumentação de Habernas, a respeito do que eledenominou “engenismo liberal”, ou seja, a possibilidade de os pais determinarem intervenções no genoma das células geminais fecundadas. O autor aprofunda a discussão ética sobre as conseqüências eugênicas de tais intervenções apontadas por Habernas e revela a perplexidade do filósofo diante das insuficiências das respostas normativas a essa questão.
POLÍTICA PÚBLICA E A NORMA POLÍTICA
Authors: Derani Cristiane 
Published: October 2014

O artigo inicia com a análise da função política do Estado e suas transformações,para chegar à ação estatal fundada nas políticas públicas. Destaca na construção de tais políticas a questão da democracia e aponta a importância da Constituição para a realização de ações que possam ser adequadas à consecução dos direitos fundamentais.