bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calcium Phosphate Hybrid Nanoparticles: Self‐Assembly Formation, Characterization, and Application as an Anticancer Drug Nanocarrier
Authors: Zhao Xin‐Yu , Zhu Ying‐Jie , Chen Feng , Lu Bing‐Qiang , Qi Chao , Zhao Jing , Wu Jin 
Published: April 2013

AbstractCalcium phosphate hybrid nanoparticles (CaP‐HNPs) have been synthesized in aqueous solution through self‐assembly by using two oppositely charged polyelectrolytes (poly(diallyldimethylammonium chloride) (PDADMAC) and poly(acrylate sodium) (PAS)) as dual templates. First, the PAS/Ca2+ and PDADMAC/PO43− complexes form through electrostatic interactions and then two complexes self‐assemble into CaP‐HNPs after mixing them together. The as‐prepared CaP‐HNPs exhibit a spherical morphology with a narrow size distribution, good dispersibility, and high colloidal stability in water. The CaP‐HNPs are explored as a nanocarrier for the anticancer drug docetaxel (Dtxl). The CaP‐HNPs show excellent biocompatibility, high drug‐loading capacity, pH‐sensitive drug‐release behavior, and high anticancer effect after being loaded with Dtxl. Therefore, the as‐prepared CaP‐HNPs are promising drug nanocarriers for cancer therapy.
Electronic Structure of Monodithiolated IronOxotungsten Heterometallic Complexes: Integer‐Spin FeW Assembly
Authors: Bose Moumita , Moula Golam , Sarkar Sabyasachi 
Published: April 2013

AbstractFeW heterometallic complexes, in which an FeX2 (X=Cl, SPh) moiety is attached to monodithiolene oxotungsten through a sulfide bridge, that is, [Ph4P]2[Cl2Fe(S)2WOS2] (1), [Ph4P]2[Cl2Fe(S)2WOS2(DMED)] (2, DMED=dimethylethylenedicarboxylate), [Ph4P]2[Cl2Fe(S)2WO(tdt)] (3, tdt=toluenedithiolate), [Ph4P]2[(SPh)2Fe(S)2WO(tdt)] (4), and [Ph4P]2[Cl2Fe(S)2WO(edt)] (5, edt=ethanedithiolate), are reported. Mössbauer and EPR spectroscopy, magnetism, electrochemistry, and electronic structural analysis based on DFT and TD‐DFT calculations show the transfer of electron from the iron center to the tungsten center, thus resulting in a ferromagnetically coupled FeIIIWV unit, along with antiferromagnetic intermolecular interactions, from the starting FeII and WVI compounds. A net spin of a S=3 ground state, which arises from ferromagnetically coupled FeIII and WV atoms, displays a rare X‐band EPR in normal mode at g≈7 in the solid state.
Parametric Jordan Form Assignment Revisited
Authors: Schlegel Miloš , Königsmarková Jana 
Published: April 2013

AbstractThe Jordan form assignment problem (complete and partial) for linear multivariable control system is formulated and completely solved by the unified Sylvester matrix equation approach. A new explicit parametrization of all state feedbacks assigning an admissible Jordan form through the minimum number of parameters is provided. The main advantage of this parametrization, unlike previous ones, is that it is explicit; thus, it can be used, not only for numeric, but also symbolic computations. This fact is demonstrated on the problem of parametrization of all output feedbacks assigning an admissible Jordan form, where Gröbner basis method is applied. Developed algorithms for Jordan form assignment by state and output feedback are implemented in the freely available Maple package.
In vitro/in vivo comparison of cefuroxime release from poly(ε‐caprolactone)–calcium sulfate implants for osteomyelitis treatment
Authors: Yaprakci Volkan , Erdemli Ozge , Kayabolen Alisan , Tezcaner Aysen , Bozkurt Fatih , Keskin Dilek 
Published: April 2013

AbstractThis study aimed to investigate the release of cefuroxime axetil (CF) and calcium from poly(ε‐caprolactone) (PCL)–calcium sulfate (CaS) implants (PCL:CaS 2:1–10% CF; PCL:CaS 2:1–20% CF; PCL:CaS 1:1–10% CF) for treating infectious bone diseases. Bioactivity, crystallinity and strength, and release profiles under standard and pressurized release conditions were studied. PCL:CaS 2:1–20% CF had slower release than 10% loading. These groups had no significant change in CF and Ca release in response to pressure. The PCL:CaS 1:1 group had the slowest release despite having higher CaS, probably due to more compaction of discs. In contrast, pressure caused significant differentiation of CF and Ca2+ release. The presence of CaS enhanced mechanical properties and bioactivity of discs. SEM and XPS results showed calcium‐phosphate containing accumulations on surfaces upon SBF incubation. CF‐loaded implants were applied in a rabbit osteomyelitis model. In vivo CF release was enhanced with increased CaS proportions, suggesting that in vivo release conditions are closer to pressurized in vitro conditions. In the control group, there was still some inflammation in the bone and no complete coverage with bone was achieved in the defect site. Discs provided a suitable surface for regeneration of bone. However, bone formation in the PCL:CaS 1:1 disc implanted group was more complete and regular than in the 2:1 group.
The power of altmetrics on a CV
Authors: Piwowar Heather , Priem Jason 
Published: April 2013

AbstractEditor's SummaryAlternative metrics demonstrate the value and influence of scholars' work apart from traditional citation counts and can enhance the impact of a CV. Altmetrics provide additional, supplementary information and can balance misleading metrics tied to particular journals. More timely than traditional metrics, altmetrics quickly reveal the impact of recent work and add authority to different types of scholarly products not captured as articles. Altmetrics can capture social media references that escape traditional metrics and reflect public engagement prompted by scholarly writing. The availability of altmetrics expands publishing opportunities to include new venues and stimulates innovative strategies for evaluating research. When included in a CV altmetrics must be accurate, clear and meaningful.
Incorporation of Pure Fullerene into Organoclays: Towards C60‐Pillared Clay Structures
Authors: Tsoufis Theodoros , Georgakilas Vasileios , Ke Xiaoxing , Van Tendeloo Gustaaf , Rudolf Petra , Gournis Dimitrios 
Published: April 2013

AbstractIn this work, we demonstrate the successful incorporation of pure fullerene from solution into two‐dimensional layered aluminosilicate minerals. Pure fullerenes are insoluble in water and neutral in terms of charge, hence they cannot be introduced into the clay galleries by ion exchange or intercalation from water solution. To overcome this bottleneck, we organically modified the clay with quaternary amines by using well‐established reactions in clay science in order to expand the interlayer space and render the galleries organophilic. During the reaction with the fullerene solution, the organic solvent could enter into the clay galleries, thus transferring along the fullerene molecules. Furthermore, we demonstrate that the surfactant molecules, can be selectively removed by either simple ion‐exchange reaction (e.g., interaction with Al(NO3)3 solution to replace the surfactant molecules with Al3+ ions) or thermal treatment (heating at 350 °C) to obtain novel fullerene‐pillared clay structures exhibiting enhanced surface area. The synthesized hybrid materials were characterized in detail by a combination of experimental techniques including powder X‐ray diffraction, transmission electron microscopy, X‐ray photoemission, and UV/Vis spectroscopy as well as thermal analysis and nitrogen adsorption–desorption measurements. The reported fullerene‐pillared clay structures constitute a new hybrid system with very promising potential for the use in areas such as gas storage and/or gas separation due to their high surface area.
Evolution of Air Breathing: Oxygen Homeostasis and the Transitions from Water to Land and Sky
Authors: Hsia Connie C. W. , Schmitz Anke , Lambertz Markus , Perry Steven F. , Maina John N. 
Published: April 2013

AbstractLife originated in anoxia, but many organisms came to depend upon oxygen for survival, independently evolving diverse respiratory systems for acquiring oxygen from the environment. Ambient oxygen tension (PO2) fluctuated through the ages in correlation with biodiversity and body size, enabling organisms to migrate from water to land and air and sometimes in the opposite direction. Habitat expansion compels the use of different gas exchangers, for example, skin, gills, tracheae, lungs, and their intermediate stages, that may coexist within the same species; coexistence may be temporally disjunct (e.g., larval gills vs. adult lungs) or simultaneous (e.g., skin, gills, and lungs in some salamanders). Disparate systems exhibit similar directions of adaptation: toward larger diffusion interfaces, thinner barriers, finer dynamic regulation, and reduced cost of breathing. Efficient respiratory gas exchange, coupled to downstream convective and diffusive resistances, comprise the “oxygen cascade”—step‐down ofPO2that balances supply against toxicity. Here, we review the origin of oxygen homeostasis, a primal selection factor for all respiratory systems, which in turn function as gatekeepers of the cascade. Within an organism's lifespan, the respiratory apparatus adapts in various ways to upregulate oxygen uptake in hypoxia and restrict uptake in hyperoxia. In an evolutionary context, certain species also become adapted to environmental conditions or habitual organismic demands. We, therefore, survey the comparative anatomy and physiology of respiratory systems from invertebrates to vertebrates, water to air breathers, and terrestrial to aerial inhabitants. Through the evolutionary directions and variety of gas exchangers, their shared features and individual compromises may be appreciated. © 2013 American Physiological Society.Compr Physiol3:849‐915, 2013.
Kupffer Cells in the Liver
Authors: Dixon Laura J. , Barnes Mark , Tang Hui , Pritchard Michele T. , Nagy Laura E. 
Published: April 2013

AbstractKupffer cells are a critical component of the mononuclear phagocytic system and are central to both the hepatic and systemic response to pathogens. Kupffer cells are reemerging as critical mediators of both liver injury and repair. Kupffer cells exhibit a tremendous plasticity; depending on the local metabolic and immune environment, then can express a range of polarized phenotypes, from the proinflammatory M1 phenotype to the alternative/M2 phenotype. Multiple M2 phenotypes can be distinguished, each involved in the resolution of inflammation and wound healing. Here, we have provided an update on recent research that has contributed to the developing delineation of the contribution of Kupffer cells to different types of liver injury, with an emphasis on alcoholic and nonalcoholic liver diseases. These recent advances in our understanding of Kupffer cell function and regulation will likely provide new insights into the potential for therapeutic manipulation of Kupffer cells to promote the resolution of inflammation and enhance wound healing in liver disease. © 2013 American Physiological Society.Compr Physiol3:785‐797, 2013.
Tunable and White‐Light Emission from Single‐Phase Ca2YF4PO4:Eu2+,Mn2+ Phosphors for Application in W‐LEDs
Authors: Geng Dongling , Shang Mengmeng , Zhang Yang , Cheng Ziyong , Lin Jun 
Published: April 2013

AbstractNovel phosphors, Ca2YF4PO4:Eu2+,Mn2+, have been prepared by high‐temperature solid‐state reactions. XRD and XPS techniques were used to investigate the purity and composition of the as‐prepared samples. The Ca2YF4PO4:Eu2+,Mn2+ phosphors exhibit broad excitation spectra ranging from 275–420 nm and the emission spectra show a broad blue emission band centered at 455 nm and a yellow emission band centered at 570 nm, which originate from the Eu2+ and Mn2+ ions, respectively. Energy transfer from the Eu2+ to Mn2+ ions in the Ca2YF4PO4 host matrix was observed and studied by luminescence spectrosccopy as well as the lifetime of the Eu2+ ions. The emission color of the Ca2YF4PO4:Eu2+,Mn2+ samples can be adjusted from blue to yellow under excitation by UV radiation of 375 nm by adjusting the Eu2+ and Mn2+ concentrations, and white‐light emission with chromaticity coordinates (0.327, 0.312) was obtained with the Ca2YF4PO4:0.015Eu2+,0.015Mn2+ sample. In addition, the temperature‐dependent photoluminescence of the as‐prepared phosphors has been investigated in detail. The results revealed that the Ca2YF4PO4 host has good thermal stability. The stable structure of the host and tunable luminescence suggest that Ca2YF4PO4:Eu2+,Mn2+ could be regarded as a good candidate for UV LED‐based white‐light emitting diodes.
Phenolic composition of virgin olive oils in cultivars for narrow hedgerow olive orchards
Authors: El Riachy Milad , Priego‐Capote Feliciano , Rallo Luis , Luque‐de Castro María Dolores , León Lorenzo 
Published: April 2013

Narrow hedgerows system (NHS) is a new concept of olive orchards characterized by minimum labor requirements, continuous mechanical harvesting, early bearing, high yield, and olive oil quality. In this work, the variability of phenolic composition of virgin olive oils (VOOs) was studied in three cultivars (Arbequina, Arbosana, and Sikitita), two planting systems (NHS: 1975 trees/ha and intensive system (IS): 333 trees/ha) and different harvesting dates (1 October and 26 November for the three cultivars; and three additional dates for the new olive Sikitita: 16 and 29 October; and 12 November). Phenolic compounds were extracted from the obtained VOOs by liquid–liquid extraction with 60:40 v/v methanol/water. The resulting hydroalcoholic extract was analyzed by liquid chromatography – diode‐array detector – fluorescence detection (LC‐DAD‐FD) for individual phenols separation–quantification. Significant differences among genotypes were found for some individual phenols at the first harvesting date. At the second harvesting date, significant differences were found between genotypes and between planting systems (p<0.05). According to the obtained results, the new Sikitita should be harvested at the beginning of the ripening period for obtaining VOO with high phenolic content. Finally, a global agronomic and oil compositional evaluation in NHS of the new cultivars bred specifically is needed for this new olive growing system.Practical applications: Narrow hedgerow is a new very high density (>1500 trees/ha) olive planting system associated to overhead vineyard harvesters that is increasingly used as it reduces drastically both labor and time needed to harvest the crop. This study focuses on the comparison of the content of phenolic compounds in olive oils originated from narrow hedgerow system and intensive system. The results can be used to determine the best time for harvesting the new olive Sikitita, recently selected for narrow hedgerow system, in order to obtain an olive oil with high phenolic content.
Stereoselective Synthesis of the C31–C41 Spirolactam Fragment of Sanglifehrin A
Authors: Yadav J. S. , Raghavendra Rao K. V. , Kavita Aala , Mohapatra Debendra K. 
Published: April 2013

AbstractA stereoselective synthesis of the spirolactam fragment (C31–C41) of a highly‐potent immunosuppressant sanglifehrin A is described. The key steps involved in this synthesis are a desymmetrization protocol, Sharpless asymmetric epoxidation, Crimmins syn aldol reaction, Barton–McCombie deoxygenation, and acid‐mediated spirolactamization.
One‐Pot Method for Regioselective Bromin­ation and Sequential Carbon–Carbon Bond‐Forming Reactions of Allylic Alcohol Derivatives
Authors: Kutsumura Noriki , Matsubara Yusuke , Niwa Kentaro , Ito Ai , Saito Takao 
Published: April 2013

AbstractAn efficient one‐pot method for the regioselective bromination of allylic alcohol derivatives (two‐step reaction sequence) followed by Sonogashira, Negishi, or Suzuki–Miyaura coupling reactions in the same reaction vessel (three‐step reaction sequence) has been developed. The key reaction in these one‐pot systems is the regioselective DBU‐promoted trans HBr elimination of vicinal dibromides bearing an adjacent O‐functional group.
A semi‐discrete central scheme for scalar hyperbolic conservation laws with heterogeneous storage coefficient and its application to porous media flow
Authors: Correa M.R. , Borges M.R. 
Published: April 2013

SUMMARYIn this paper, we develop a new Godunov‐type semi‐discrete central scheme for a scalar conservation law on the basis of a generalization of the Kurganov and Tadmor scheme, which allows for spatial variability of the storage coefficient (e.g. porosity in multiphase flow in porous media) approximated by piecewise constant interpolation. We construct a generalized numerical flux at element edges on the basis of a nonstaggered inhomogeneous dual mesh, which reproduces the one postulated by Kurganov and Tadmor under the assumption of homogeneous storage coefficient. Numerical simulations of two‐phase flow in strongly heterogeneous porous media illustrate the performance of the proposed scheme and highlight the important rule of the permeability–porosity correlation on finger growth and breakthrough curves. Copyright © 2013 John Wiley & Sons, Ltd.
Microfractures within the fault damage zone record the history of fault activity
Authors: Mizoguchi Kazuo , Ueta Keiichi 
Published: April 2013

AbstractFor faults without sedimentary covers, there is no robust method to obtain paleoseismic data that is crucial for the prediction of future damaging earthquake events. Sudden failure along faults during earthquakes induces off‐fault damage surrounding such basement faults. We showed that the Quaternary‐active fault has the damage zone characterized by a fracture density that decays exponentially with distance from the fault for both healed and open microfractures. In contrast, Quaternary‐inactive faults contain only healed microfracture damage zone. Cross‐cutting relationships between microfractures and a minimum healing temperature of ~100°C suggest that healed microfractures formed before, and at deeper levels, than did unhealed microfractures. The damage zone defined by open microfractures reflects the recent fault movement during exhumation, associated with erosion and regional uplift, from the maximum depth at which microfractures may remain unhealed. Microfracture analysis can therefore be used to examine the history of basement fault activity.
Bioinformatics Tools for Marker Discovery in Plant Breeding
Authors: Ophir Ron 
Published: April 2013

AbstractIn the last decade, intensive research has been invested in marker‐assisted selection (MAS). In parallel, there have been great advances in high‐throughput genomic technology, such as microarrays and next‐generation sequencing. These technologies overcome barriers for crops that do not have genomic information available and shorten the time from genomic darkness to discovery of an overwhelming number of markers. Consequently, MAS has become an available approach for any crop. Herein, the bioinformatics tools for high‐throughput marker discovery using microarrays and high‐throughput sequencing are reviewed and options for using them in MAS are suggested.
Nickel Hydroxide and Intercalated Graphene with Ionic Liquid Nanocomposite‐modified Electrode for Sensing of Glucose
Authors: Wang Lu , Nie Fei , Zheng Jianbin 
Published: April 2013

AbstractA novel non‐enzymatic glucose sensor based on nickel hydroxide and intercalated graphene with ionic liquid (G‐IL) nanocomposite modified glass carbon electrode was fabricated. Scanning electron microscope, Fourier transform infrared spectra and energy dispersive X‐ray spectroscopy of the nanocomposite confirmed the morphology and ingredient of Ni(OH)2 as well as G‐IL. Moreover, experimental results of cyclic voltammetry, electrochemical impedance spectroscopy and chronoamperometry indicated the sensing properties of Ni(OH)2 at Ni(OH)2/G‐IL modified electrode towards the typical electrocatalytic oxidation process of glucose at 0.43 V in 0.10 M NaOH. The current response was linearly related to glucose concentration in a range from 0.5 to 500 μM with a detection limit of 0.2 μM (S/N = 3) and sensitivity of 647.8 μA mM−1 cm−2. The response time of the sensor to glucose was less than 2 s. This work may be expected to develop an excellent electrochemical sensing platform of G‐IL as a catalysis carrier.
Comparison of influenza virus replication fidelity in vitro using selection pressure with monoclonal antibodies
Authors: Wong Karen Ka Yin , Rockman Steve , Ong Chi , Bull Rowena , Stelzer‐Braid Sacha , Rawlinson William 
Published: April 2013

AbstractThe replication fidelity of reassortant A/Fujian/411/02(H3N2)‐like influenza viruses was assessed by in vitro detection of escape mutants developing under selective pressure from monoclonal antibodies. The results showed A/Wyoming/3/03(H3N2) possessed lower fidelity relative to the A/California/7/04(H3N2) and A/Wisconsin/57/05(H3N2) viruses through the emergence of mutant viruses carrying H156Q hemagglutinin mutation which allows antibody escape. Using the neutralization assay to compare the fidelity of reassortant pandemic A/California/7/09(H1N1) viruses, the pandemic virus was shown to possess relative higher fidelity compared to A/Wyoming/3/03. This higher fidelity may contribute to the lack of major antigenic changes in the pandemic virus since the emergence in 2009. J. Med. Virol. 85: 1090–1094, 2013. © 2013 Wiley Periodicals, Inc.
Multiple clusters of A(H1N1)pdm09 virus circulating in severe cases of influenza during the 2010–2011 season: A phylogenetic and molecular analysis of the neuraminidase gene
Authors: Piralla Antonio , Pariani Elena , Campanini Giulia , Rovida Francesca , Ranghiero Alberto , Fiorina Loretta , Amendola Antonella , Zanetti Alessandro , Baldanti Fausto 
Published: April 2013

AbstractThe molecular characterization of circulating influenza A viruses is crucial to detect mutations potentially involved in increased virulence, drug resistance and immune escape. A molecular and phylogenetic analysis of A(H1N1)pdm09 neuraminidase (NA) gene sequences from different patient categories defined according to the severity of influenza infection were analyzed. A total of 126 influenza A(H1N1)pdm09 positive samples from patients with severe infections in comparison with those with moderate and mild infections was performed in Lombardy (Northern Italy, nearly 10 million inhabitants) during the 2010–2011 season. NA sequences included in this study segregated into five distinct clusters. Nineteen amino acid substitutions were detected exclusively in NA sequences of viruses identified in patients with severe or moderate influenza infection. Three of them (F74S, S79P, E287K) were observed in virus strains with the 222G/N hemagglutinin mutation. None of NA sequences under study had mutations related to the resistance to the NA inhibitors. Four out of 126 (3.2%) NA sequences from patients with severe infection lost a N‐linked glycosylation site due to the change from N to K at residue 386. Two additional N‐linked glycosylation sites in the NA stalk region (residues 42 and 44) were found in 12 (9.5%) NA sequences. Sporadic NA mutations were detected in NA viral sequences from critically ill patients, and no variants with reduced sensitivity to NA inhibitors were observed either in treated or untreated patients. J. Med. Virol. 85: 944–952, 2013. © 2013 Wiley Periodicals, Inc.