bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progress in Large‐Scale Carbon Capture Deployment: Status, Challenges, and Prospects
Authors: Zentou Hamid , AlZahrani Abdullah A. , Behar Omar , Tayeb Ali M. , Abdelnaby Mahmoud M. 
Published: February 2025

AbstractThe climate math is clear: carbon capture and storage (CCUS) is an essential climate mitigation technology, without which achieving net‐zero emission targets will be virtually impossible. This requires periodic assessment and continuous improvement of the technology from various perspectives. This short review highlights the current state of CCUS deployment, recent achievements, and associated challenges. CCUS project pipeline is at an all‐time high in terms of both the number of facilities and carbon dioxide capture capacity. Currently, 47 operational CCUS projects have an annual CO2 capture capacity of 50.5 Mt CO2/year. The total project pipeline capacity is expected to reach 600 Mt CO2/year. The natural gas sector is the major contributor, accounting for more than 65% of the total carbon capture capacity. While significant progress is made in recent years, particularly in North America and Europe, CCUS deployment faces several significant challenges that are multifaceted, encompassing technical, economic, regulatory, and social dimensions. Policymakers, industry leaders, investors, and the general public are increasingly feeling the urgency to address climate change, accelerating many mitigation efforts, including CCUS deployment, in leading regions globally. However, to meet climate change mitigation targets, global investment in CCUS deployment must grow even faster this decade.
Nitrogen‐Doped Graphene/Cellulose Fibers Double‐Coated Asymmetric Separator for High‐Performance Lithium‐Sulfur Batteries
Authors: Guo Hao‐Nan , Dong Wei‐Xu , Fang Zhi‐Yong , Hu Lei , Chen Jingwei , Chen Li‐Feng 
Published: February 2025

AbstractLithium‐Sulfur (Li─S) batteries have the advantages of low cost and high capacity, but the cathode shuttle effect and the growth of anode lithium dendrites have hindered their development. Among the various modification strategies, separator modification offers a promising approach to address issues on both anodes and cathodes. In this study, a bifunctional asymmetric polypropylene (PP) separator is modified with nitrogen‐doped reduced graphene oxide (N–rGO) on the cathode side and cellulose fibers (CF) on the anode side to address the challenges associated with both electrodes. CF effectively promotes the uniform deposition of lithium metal and significantly inhibits the growth of lithium dendrites. In addition, N–rGO with a porous structure and nitrogen‐doped active sites can not only suppress lithium polysulfide shuttling by physical and chemical adsorption but also catalyze the kinetics of the redox reaction, leading to an increased specific capacity of the battery. The Li─S battery incorporating N–rGO@PP@CF separator exhibits an impressive specific capacity of 1294 mAh g−1 at a current rate of 1 C, with a remarkably low average capacity decay of 0.076% per cycle over 500 cycles. The synergistic effect between CF and N–rGO modification on asymmetric separators provides a promising guideline for developing high‐performance Li─S batteries.
Functional Polarization of Liver Macrophages by Glyco Gold Nanoparticles
Authors: Fernandez Alarcon Jennifer , Perez Schmidt Patricia , Panini Nicolo , Caruso Francesca , Violatto Martina B. , Sukubo Naths Grazia , Martinez‐Serra Alberto , Ekalle‐Soppo Charlotte Blanche , Morelli Annalisa , Moscatiello Giulia Yuri , Grasselli Chiara , Corbelli Alessandro , Fiordaliso Fabio , Kelk Joe , Petrosilli Laura , d'Orazio Giuseppe , Mateu Ferrando Ruth , Verdaguer Ferrer Ariadna , Fornaguera Cristina , Lay Luigi , Fumagalli Stefano , Recchia Sandro , Monopoli Marco P. , Polito Laura , Bigini Paolo , Sitia Giovanni 
Published: February 2025

AbstractMacrophages are crucial drivers of innate immunity. Reprogramming macrophages to a restorative phenotype in cancer or autoimmune diseases can stop their cancer‐promoting activity or trigger anti‐inflammatory immunity. Glycans have emerged as key components for immunity as they are involved in many pathophysiological disorders. Previous studies have demonstrated that supraphysiological amounts of mannose (Man) or sialic acid (Sia) can inhibit tumor growth and stimulate differentiation of regulatory T cells. Man is known to affect glucose metabolism in glycolysis by competing for the same intracellular transporters and affecting macrophage polarization, whereas Sia alters macrophage differentiation via signaling through Siglec‐1. Herein, this work describes a macrophage targeting platform using gold nanoparticles (GNPs) functionalized with Man and Sia monosaccharides which exhibit high liver tropism. A single dose of glyco‐GNPs can convert macrophages to a restorative phenotype in two completely different immune environments. Man promotes tumor‐associated macrophages toward an antitumorigenic activity in a MC38 liver colorectal cancer model by secretion of TNF‐α, IL ‐1β, and IL ‐6 in the tumor microenvironment. However, in a proinflammatory environment, as observed in a mouse model of autoimmune disease, primary biliary cholangitis, Man impairs the production of TNF‐α, IL‐1β, Arg1, and IL‐6 cytokines. The results probe the dual role of Man in macrophage repolarization in response to the immune system. This study is a proof‐of‐concept that demonstrates that nanomedicine using specific glycans designed to target other immune cells such as myeloid cells, are a promising strategy not only against cancer but also against other pathologies such as autoimmune diseases.
Brightened Optical Transition Hinting to Strong Spin‐Lattice Coupling in a Layered Antiferromagnet
Authors: Multian Volodymyr , Wu Fan , van der Marel Dirk , Ubrig Nicolas , Teyssier Jérémie 
Published: February 2025

AbstractTwo‐dimensional (2D) van der Waals magnets show strong interconnection between their electrical, magnetic, and structural properties. Here, the emergence of a luminescent transition is revealed upon crossing the Néel transition temperature of CrPS4, a layered antiferromagnetic semiconductor. This luminescent transition occurs above the lowest absorption level. The optical transitions are attributed to excited states of the t2g orbitals of the Cr3+ ions, which are influenced by the distortion of the octahedral crystal field. Specifically, the vicinity of the Néel temperature, the distortion switches from an anti‐polar to a polar arrangement, thereby not only promoting an additional luminescent pathway but also significantly strengthening the static dipole moment detected by a marked enhancement in the intensity of the second harmonic generation. These results strongly encourage further investigation into the multiferroic properties and potential coupling mechanisms in CrPS4.
Enhancer RNA Transcriptome‐Wide Association Study Reveals a Distinctive Class of Pan‐Cancer Susceptibility eRNAs
Authors: Chen Wenyan , Wang Zeyang , Wang Yinuo , Lin Jianxiang , Chen Shuxin , Chen Hui , Ma Xuelian , Zou Xudong , Li Xing , Qin Yangmei , Xiong Kewei , Ma Xixian , Liao Qi , Qiao Yunbo , Li Lei 
Published: February 2025

AbstractMany cancer risk variants are located within enhancer regions and lack sufficient molecular interpretation. Here, we constructed the first comprehensive atlas of enhancer RNA (eRNA)‐mediated genetic effects from 28 033 RNA sequencing samples across 11 606 individuals, identifying 21 073 eRNA quantitative trait loci (eRNA‐QTLs) significantly associated with eRNA expression. Mechanistically, eRNA‐QTLs frequently altered binding motifs of transcription factors. In addition, 28.48% of cancer risk variants are strongly colocalized with eRNA‐QTLs. A pan‐cancer eRNA‐based transcriptome‐wide association study is conducted across 23 major cancer types, identifying 626 significant cancer susceptibility eRNAs predicted to modulate cancer risk via eRNA, from which 54.90% of the eRNA target genes are overlooked by traditional gene expression studies, and most are essential for cancer cell proliferation. As proof of principle validation, the enhancer functionality of two newly identified susceptibility eRNAs, CCND1e and SNAPC1e, is confirmed through CRISPR inhibition and shRNA‐mediated knockdown, resulting in a marked decrease in the expression of their respective target genes, consequently suppressing the proliferation of prostate cancer cells. The study underscores the essential role of eRNA in unveiling new cancer susceptibility genes and establishes a strong framework for enhancing our understanding of human cancer etiology.
Ge2Sb2Se4Te‐Based Optical Switch with Ultra‐High Contrast Ratio by Multilayer Fabry–Perot Cavity
Authors: Tang Zhiyang , Li Chensheng , Pan Ruhao , Wang Bo , Liu Yunan , Wang Qianyu , Tan Junhao , Xiang Yuan , Yang Haifang , Li Junjie 
Published: February 2025

AbstractOptical switches always desire a high contrast ratio in optical logic circuits and optical communication devices. Although phase change materials are widely applied to design optical switches for their rapid phase change, the high contrast ratio is still hardly achieved for the intrinsic loss of traditional PCMs. Here, the study demonstrates an optical switch with an ultra‐high contrast ratio by introducing the Ge2Sb2Se4Te (GSST) into a multilayer film structure treated as a Fabry–Perot (FP) cavity. The reflectance of the multilayer system can be actively tuned by the phase change of GSST for the FP resonance to achieve an optical switch response. By designing the thicknesses of each layer in the multilayer film, the operating wavelength and the contrast ratio of the switch can be precisely controlled, and an ultra‐high contrast ratio of 2410/735 (simulation/experiment) for the optical switch is constructed in the near‐infrared band. The development of the GSST‐based optical switch paves a new way to realize a high optical contrast ratio and offers a new strategy for high‐performance optical devices.
Identification of a Novel Substrate for eEF2K and the AURKA‐SOX8 as the Related Pathway in TNBC
Authors: Wan Xiaoya , Gong Rong , Zhao Xiaobao , Li Yizhi , Shan Tianjiao , Zhong Changxin , Zhu Rongfeng , Chen Zonglin , Jiang Shilong , He Linhao , Cao Shijun , Tian Sheng , Yang Jinming , Ye Na , Yi Wenjun , Cheng Yan 
Published: February 2025

AbstractEukaryotic elongation factor 2 kinase (eEF2K) has been considered as a putative target for cancer therapy; however, the underlying mechanisms of eEF2K in triple‐negative breast cancer (TNBC) progression remain to be fully elucidated. In this study, it is shown that eEF2K is highly expressed in TNBC and is associated with poor prognosis. In vitro, in vivo, and patient‐derived organoid experiments demonstrate that knockdown of eEF2K significantly impedes progression of TNBC. Proteomic analysis and confirmation experiments reveal that eEF2K positively regulates the mRNA and protein expressions of sex‐determining region Y‐box 8 (SOX8). Mechanistically, eEF2K binds to and phosphorylates aurora kinase A (AURKA) at S391, a newly identified phosphorylation site critical for maintaining AURKA protein stability and kinase activity. Moreover, the compound C1, a molecular glue to degrade eEF2K, is optimized by designing and synthesizing its derivatives using reasonable structure‐based optimization approach. The new compound C4 shows better ability to degrade eEF2K and stronger anti‐cancer activity than C1. These findings not only uncover the pivotal role of the eEF2K/AURKA/SOX8 axis in TNBC progression, but also provide a promising lead compound for developing novel drug for treatment of TNBC.
A Hf(IV)‐Coordinated NIR‐II Fluorescence “Turn‐On” Nanoprobe for Precise Imaging‐Guided Surgery in Breast Cancer
Authors: He Yueyang , Lin Jinyan , Bai Jingwen , Shen Xiao , Lou Kangliang , Zhu Yuanyuan , Qiao Zishan , Chen Weiling , Li Yang , Liu Xiaolong , Zhang Guojun 
Published: February 2025

AbstractBreast‐conserving surgery (BCS) has become the standard care for early‐stage breast cancer. The accurate assessment of tumor margins is urgently required for BCS because positive resection margins often lead to local recurrence. To address this clinical dilemma, a Hf(IV)‐coordinated NIR‐II fluorescence “turn‐on” nanoprobe based on the clinically approved NIR‐II fluorescent dye indocyanine green (ICG) for intraoperative tumor visualization is developed. Notably, the fluorescence of ICG can be efficiently quenched by Hf(IV) and subsequently recovered in vivo, showing a remarkable fluorescence “quenching‐recovery‐amplification” capacity. This nanoprobe can effectively accumulate in tumor sites, accurately identifying submillimeter‐sized primary and residual tumors with high sensitivity. In addition, subcutaneous, muscle‐infiltrating, and orthotopic breast cancer models are built to repeatedly prove that this ultrasensitive nanoprobe is feasible for precise imaging‐guided surgery in breast cancer. Overall, this study constructs an activatable fluorescent nanoprobe for real‐time intraoperative tumor margin visualization, holding promise for complete surgical resection and reduction of local recurrence.
Biomimetic Pyramid Structure Film for Enhancing Building Radiative Cooling
Authors: Pan Qian‐Hao , Wang Mei‐Hua , Huang Zong‐Ying , Qiu Xiao‐Jing , Wang Yu‐Tao , Zhao Fu‐Xing , Zhu Meng‐Han , Guo Xin , Chen Chen , Zhang Si‐Chao , Wang Jin‐Long , He Zhen , Yu Shu‐Hong 
Published: February 2025

AbstractRadiative cooling has emerged as a promising technique for reducing energy consumption in building thermal management due to its passive cooling property and no external energy requirement. Despite significant advances, scalable production of artificial photonic radiators with periodic structures, environmental stability, high radiative cooling performance, and economic applicability is still challenging in most state‐of‐the‐art radiative coolers. Rational structure and materials design are essential to promote daytime sunlight reflectance while maintaining a high emissivity within the atmospheric window (8–13 µm). In this work, inspired from the unique hair structure of heat‐resistant organisms, a biomimetic micro‐pyramid shaped structure model is analyzed. By mimicking the intricate design with a silicon template, a radiative cooling film containing specialized micro‐pyramid structure is fabricated by integrating high dielectric constant materials with polymers and receiving PVDF coating. The resulting film boasts a solar reflectance of 97.3% and an exceeding 98% infrared light emission within the atmospheric window. In addition, silicon rubber endows this membrane with strong tensile and rebound properties while surficial hydrophobicity protects the membrane from dust infestation. Considering the manufacturing simplicity and cost‐effectiveness, this method shows great potential for mass production, shedding light on building thermal management.
Excited‐State Structural Dynamics of the Cubane‐Type Metal Cluster [Cu4I4(py)4] Explored by Time‐Resolved X‐Ray Liquidography
Authors: Kim Doyeong , Ki Hosung , Im Donghwan , Lee Yunbeom , Lee Seonggon , Heo Jun , Eom Seunghwan , Choi Eun Hyuk , Ahn Doo‐Sik , Ihee Hyotcherl 
Published: February 2025

AbstractCubane‐type metal clusters respond uniquely to stimuli like light and electric potential, resulting in behaviors such as crystal‐to‐crystal phase transitions. While structural adaptability is known to be linked to these responses, direct experimental evidence for the associated structural changes has been missing. This study addresses this gap by examining the structural dynamics of the copper(I) iodide cubane (Cu4I4(py)4, py = pyridine) upon photoexcitation using time‐resolved X‐ray liquidography. The results reveal: 1) 100 picoseconds (ps) after excitation, two distinct excited states—the cluster‐centered triplet (3CC) state and the (metal+halide)‐to‐ligand charge transfer triplet (3(M/X)LCT) state—are present; 2) the 3(M/X)LCT state decays with an apparent time constant of 1.21 ns, primarily transitioning to the 3CC state, with a small fraction undergoing decay to the ground state (GS); and 3) the 3CC state eventually returns to the GS. The molecular structures, provided for these states serve as benchmarks for theoretical studies. Importantly, the 3CC structure exhibits significant distortion in the Cu4I4 core and reduced symmetry, findings that are unanticipated by previous models. This comprehensive investigation deepens the understanding of the structural transformations occurring upon photoexcitation, with a potential impact on future applications of these compounds as versatile components in photosensitive metal–organic frameworks.
Hydrogen‐Associated Filling‐Controlled Mottronics Within Thermodynamically Metastable Vanadium Dioxide
Authors: Zhou Xuanchi , Jiao Yongjie , Lu Wentian , Guo Jinjian , Yao Xiaohui , Ji Jiahui , Zhou Guowei , Ji Huihui , Yuan Zhe , Xu Xiaohong 
Published: February 2025

AbstractThe discovery of hydrogen‐associated topotactic phase modulations in correlated oxide system has emerged as a promising paradigm to explore exotic electronic states and physical functionality. Here hydrogen‐induced Mott phase transitions are demonstrated for metastable VO2 (B) toward new electron‐itinerant hydrogenated phases via introducing non‐equilibrium condition, delicately delivering a rich spectrum of hydrogen‐associated electronic states. Of particular interest, the highly robust but reversible hydrogenated phase achievable in metastable VO2 (B) significantly benefits protonic device applications, which is in contrast with well‐known VO2 (M1), where the metallic hydrogenated phase readily turns into insulating state with extensive hydrogen doping. Establishing correlated VO2 at metastable status fundamentally surpasses the thermodynamic restrictions to expand the adjustability in their electronic structure, giving rise to new electronic states and a superior resistive switching of 102–105 to the counterparts in widely‐reported VO2 (M1). Utilizing the theoretical calculations and synchrotron radiation analysis, the hydrogen‐associated phase modulation in metastable VO2 (B) is dominantly driven by band‐filling‐controlled orbital reconfiguration, while the concurrent structural evolution unveils a strong ion‐electron‐lattice coupling. The present work provides fundamentally new tuning knob for adjusting the energy landscape of electron‐correlated system, advancing the rational design of unachievable electronic states in hydrogen‐related equilibrium phase diagram.
Nanodot‐Inspired Precise Bacterial Gene Suppression in a Smart Hydrogel Bandage for Underwater Wound Healing
Authors: Zhang Qingsong , Lu Menghan , Ou Richang , Lin Hong , Xuan Guanhua , Wang Xiudan , Xu Xiaofeng , Zhang Weiwei , Wang Guoqing 
Published: February 2025

AbstractThe complex and dynamic nature of aquatic ecosystems, particularly in marine environments, makes managing wound infections a significant challenge for individuals engaged in underwater activities and for aquatic organisms. Although antibiotics have played a critical role in safeguarding humans and aquatic health, their risk of drug resistance and environmental impact present substantial obstacles to long‐term sustainability. Using fin rot disease in turbot (Scophthalmus maximus) caused by infection of Vibrio anguillarum (V. anguillarum) as a model, a new strategy is presented that employs a carbon dot (CD)‐based antisense oligonucleotide (ASO) delivery system, combined with an adhesive hydrogel, to achieve targeted gene silencing of V. anguillarum for underwater healing. The CDs that cause enhanced cytoplasmic membrane permeability, efficiently deliver ASOs into V. anguillarum without requiring additional equipment or chemical facilitators. The specific design of the ASO sequence enables targeted silencing of empA, achieving efficiency as high as 71.2%. An adhesive hydrogel is applied to boost the local concentration of ASO/CDs at wound sites in seawater, effectively sealing the infected area and preventing fin rot disease in turbot. This study pioneer targeted bacterial gene regulation using CD‐based delivery integrated with a hydrogel bandage, offering practical solutions for managing underwater bacterial diseases.
Ionic Liquid‐Based Electrolyte with Multiple Hydrogen Bonding Network Enabling High‐Voltage Stable Proton Batteries Across Wide Temperature Range
Authors: Dong Xiaoyu , Li Zhiwei , Xu Hai , Wu Zhiyuan , Meng Fanhao , Liu Shuzhi , Dou Hui , Zhang Xiaogang 
Published: February 2025

AbstractProton batteries are strong contender for next‐generation energy storage due to their high safety and rapid response. However, the narrow electrochemical window of acidic aqueous electrolytes limits their energy density and stability. Here, an ionic liquid (IL)‐based electrolyte (EMImOTf‐H3PO4) containing H3PO4 in polar IL solvent 1‐ethyl‐3‐methylimidazolium trifluoromethanesulfonate (EMImOTf) is developed for stable high‐voltage energy storage. H3PO4 serving as a proton source interacts with both EMIm+ and OTf−, forming an intricate hydrogen bonding network that effectively prevents electrolyte decomposition at high voltage. The half‐cell in EMImOTf‐H3PO4 electrolyte and pre‐protonated vanadium hexacyanoferrate (H‐VHCF) cathode demonstrates a 126% improvement in Coulombic efficiency over aqueous electrolytes at a current density of 1 A g−1. The fabricated PTCDA/MXene//EMImOTf‐H3PO4//H‐VHCF full battery achieves an operating voltage of 2 V at room temperature, surpassing currently reported values for proton batteries. After 30 000 cycles at 5 A g−1, the battery retains 86.1% of its initial capacity. It delivers an energy density of 87.5 Wh kg−1 and a power density of 30.6 kW kg−1 at room temperature, and can maintain stable operation across a temperature range of 110 °C (−60 ∼ 50 °C). These findings present new possibilities for proton batteries in all‐weather grid‐scale energy storage applications.
Noise Spectroscopy and Electrical Transport In NbO2 Memristors with Dual Resistive Switching
Authors: Kumar Nitin , Han Jong E. , Beckmann Karsten , Cady Nathaniel , Sambandamurthy G. 
Published: February 2025

AbstractNegative differential resistance (NDR) behavior observed in several transition metal oxides is crucial for developing next‐generation memory devices and neuromorphic computing systems. NbO2‐based memristors exhibit two regions of NDR at room temperature, making them promising candidates for such applications. Despite this potential, the physical mechanisms behind the onset and the ability to engineer these NDR regions remain unclear, hindering further development of these devices for applications. This study employed electrical transport and ultra‐low frequency noise spectroscopy measurements to investigate two distinct NDR phenomena in nanoscale thin films of NbO2. By analyzing the residual current fluctuations as a function of time, spatially inhomogeneous and non‐linear conduction are found near NDR‐1 and a two‐state switching near NDR‐2, leading to an insulator‐to‐metal (IMT) transition. The power spectral density of the residual fluctuations exhibits significantly elevated noise magnitudes around both NDR regions, providing insights into physical mechanisms and device size scaling for electronic applications. A simple theoretical model, based on the dimerization of correlated insulators, offers a comprehensive explanation of observed transport and noise behaviors near NDRs, affirming the presence of non‐linear conduction followed by an IMT connecting macroscopic device response to transport signatures at the atomic level.