bluuebunny/crossref_metadata_2025_split huggingface dataset:
Into the blue: the importance of murine lacZ gene expression profiling in understanding and treating human disease
Authors: Armit Chris 
Published: October 2015

ABSTRACT
The International Mouse Phenotyping Consortium (IMPC) is a major international effort to explore the effects of knocking out 20,000 genes in the mouse. A new study by White and colleagues, published in the current issue of Disease Models & Mechanisms, demonstrates the usefulness of lacZ in situ reporter expression patterns in extending our understanding of genotype-phenotype relationships as part of the IMPC high-throughput screen. In situ gene expression profiling is invaluable for evaluating compartment-specific gene expression patterns, and these enrich our understanding of the role of genes in a great number of biological processes in multiple organ systems. Furthermore, the complexity of gene expression patterns informs our understanding of how genes influence lethality. This Editorial aims to highlight ways in which the lacZ expression profiles can impact on biomedical research by uncovering as-yet-unknown genotype-phenotype relationships, and through predicting the role of genes in health and disease.
Rhodoscirpus (Cyperaceae: Scirpeae), a new South American sedge genus supported by molecular, morphological, anatomical and embryological data
Authors: Léveillé-Bourret Étienne , Donadío Sabina , Gilmour Claire N. , Starr Julian R. 
Published: October 2015

AbstractIn its broadest sense, Scirpus consists of a heterogeneous assemblage of up to 250 species, but modern circumscriptions suggest that only 40–50 species are part of the genus. Despite a narrower definition of the genus, atypical species continue to be segregated from Scirpus with a common pattern being the removal of Southern Hemisphere taxa to other genera and tribes. In South America, the morphology of remaining Scirpus species also suggests that they are not closely related to Scirpus s.str., but most of these taxa are only known from their types, making a detailed analysis of their generic affinities difficult. One notable exception is Scirpus asper, a species that is relatively common in the mountains and adjacent lowlands of Peru south to Argentina. Although this species possesses features used in the circumscription of Scirpus, such as cauline leaves, flat leaf blades and anthelate inflorescences, it is known to differ from Scirpus s.str. by its Schoenus‐type embryo, and most of its presumed allies are now placed in different genera (e.g., Scirpus analecti ≡ Cypringlea analecta; Scirpus giganteus ≡ Androtrichum giganteum). In this study, we use DNA sequence data from the plastid (matK, ndhF) and nuclear (ETS‐1f) genomes to demonstrate that Scirpus asper is not closely related to Scirpus s.str., but sister to Phylloscirpus within the predominantly South American Zameioscirpus clade (Amphiscirpus, Phylloscirpus, Zameioscirpus). When combined with morphological, anatomical and embryological data, results indicate that S. asper is best treated as the sole species of a new monotypic genus, Rhodoscirpus. The implications of these results on the taxonomy of tribe Scirpeae are discussed.
EDUCATION AS A FACTOR OF OPTIMIZATION OF STATE YOUTH POLICY IN THE RUSSIAN FEDERATION
Authors: Бакалдина  , Bakaldina Elena , Елисеев  , Eliseev Anatoliy 
Published: October 2015

The article proposes an understanding of the system of education as a factor of optimization of state youth policy in the Russian Federation. Youth education determines the necessity of forming permanent growth of knowledge of fundamental nature on every level of basic education. The introduction of federal state educational standards is understood as a new impetus to the development of state youth policy.
The article discusses three levels of training for young people in the transition to the Bologna system: special, socio-professional and professional individual.
Have Racial and Ethnic Disparities in the Quality of Health Care Relationships Changed for Children With Developmental Disabilities and ASD?
Authors: Magaña Sandra , Parish Susan L. , Son Esther 
Published: October 2015

Abstract
The aim of this study was to determine if racial and ethnic disparities in the quality of provider interaction have changed between 2006 and 2010 for children with developmental disabilities and autism spectrum disorders (ASD). Data from the 2005/2006 and 2009/2010 National Survey of Children With Special Health Care Needs were analyzed. Results show that racial and ethnic disparities in the quality of provider interactions were substantial in both 2005/2006 and 2009/2010. Black and Latino parents were significantly less likely than White parents to report that their provider spent enough time with their child and was sensitive to the family's values. Racial and ethnic disparities in health care quality were found to be unchanged over time. Research and policy implications are discussed.
Testing Math or Testing Language? The Construct Validity of the KeyMath-Revised for Children With Intellectual Disability and Language Difficulties
Authors: Rhodes Katherine T. , Branum-Martin Lee , Morris Robin D. , Romski MaryAnn , Sevcik Rose A. 
Published: October 2015

Abstract
Although it is often assumed that mathematics ability alone predicts mathematics test performance, linguistic demands may also predict achievement. This study examined the role of language in mathematics assessment performance for children with intellectual disability (ID) at less severe levels, on the KeyMath-Revised Inventory (KM-R) with a sample of 264 children, in grades 2–5. Using confirmatory factor analysis, the hypothesis that the KM-R would demonstrate discriminant validity with measures of language abilities in a two-factor model was compared to two plausible alternative models. Results indicated that KM-R did not have discriminant validity with measures of children's language abilities and was a multidimensional test of both mathematics and language abilities for this population of test users. Implications are considered for test development, interpretation, and intervention.
Long Noncoding RNAs in Urine Are Detectable and May Enable Early Detection of Acute T Cell–Mediated Rejection of Renal Allografts
Authors: Lorenzen Johan M , Schauerte Celina , Kölling Malte , Hübner Anika , Knapp Monika , Haller Hermann , Thum Thomas 
Published: October 2015

AbstractBACKGROUNDLong noncoding RNAs (lncRNAs) are novel intracellular noncoding ribonucleotides regulating the genome and proteome. They are detectable in the blood of patients with acute kidney injury. We tested whether lncRNAs are present in urine and may serve as new predictors of outcome in renal transplant patients with acute rejection.METHODSA global lncRNA expression analysis was performed with RNA from urine of patients with acute T cell–mediated renal allograft rejection and control transplant patients. Deregulated lncRNAs were confirmed in kidney biopsies and urine in a validation cohort of 62 patients with acute rejection, 10 of them after successful antirejection therapy, and 31 control transplant patients.RESULTSA global screen revealed several lncRNAs to be deregulated in urine of patients with acute rejection. Three intergenic lncRNAs, LNC-MYH13-3:1, RP11-395P13.3-001, and RP11-354P17.15-001, were most strongly altered. These were validated in the whole cohort of patients. RP11-395P13.3-001 and RP11-354P17.15-001 were upregulated in patients with acute rejection compared with controls. Only levels of RP11-354P17.15-001 normalized in patients with acute rejection after successful antirejection therapy. RP11-354P17.15-001 was associated with higher decline in glomerular filtration rate 1 year after transplantation. In vitro, in tubular epithelial cells, all lncRNAs were enriched by interleukin-6 treatment, but only RP11-395P13.3-001 and RP11-354P17.15-001 increased in cell culture supernatant, indicating that these lncRNAs might be secreted under inflammatory conditions.CONCLUSIONSlncRNAs are strongly altered in urine of patients with acute rejection. Urinary RP11-354P17.15-001 may serve as a novel biomarker of acute kidney rejection, identifying patients with acute rejection and predicting loss of kidney function.
Reference Values and Release Kinetics of B-Type Natriuretic Peptide Signal Peptide in Patients with Acute Myocardial Infarction
Authors: Liebetrau Christoph , Gaede Luise , Dörr Oliver , Blumenstein Johannes , Rosenburg Stefanie , Hoffmann Jedrzej , Troidl Christian , Hamm Christian W , Nef Holger M , Möllmann Helge , Richards A Mark , Pemberton Chris J 
Published: October 2015

Abstract

BACKGROUND
The signal peptide for human B-type natriuretic peptide preprohormone (BNPsp), which is released from cardiomyocytes, is increased in plasma of patients with acute myocardial infarction (AMI); however, its exact release kinetics have not been defined.

METHODS
We measured BNPsp and high-sensitivity cardiac troponin T (hs-cTnT) in a reference group of individuals without structural heart disease (n = 285) and determined the release kinetics of these biomarkers in patients (n = 29) with hypertrophic obstructive cardiomyopathy undergoing transcoronary ablation of septal hypertrophy (TASH), a procedure allowing exact timing of onset of iatrogenic AMI. Blood samples were collected before TASH and at numerous preselected time points after TASH.

RESULTS
The reference median BNPsp concentration was 53.4 pmol/L [interquartile range (IQR) 47.0–61.0; 95th percentile 85.9 pmol/L; 99th percentile 116.3 pmol/L]. Baseline concentrations in patients undergoing TASH were higher than in the reference group [91.9 pmol/L (IQR 62.9–116.4); P &lt; 0.0001]. BNPsp increased significantly, peaking at 15 min after induction of AMI [149.6 pmol/L (109.5–204.9) vs baseline; P = 0.004] and declining slowly thereafter, falling below the preprocedural value after 8 h (P = 0.014). hs-cTnT increased significantly 15 min after induction of AMI [26 ng/L (19–39) vs 18 ng/L (11–29); P = 0.001] and remained high at all later time points.

CONCLUSIONS
BNPsp concentrations increased immediately after AMI induction, providing early evidence of myocardial injury. The release kinetics of BNPsp differed from those of hs-cTnT. These findings provide information that should help in establishing the diagnostic value of BNPsp in the setting of early AMI.
STARD 2015: An Updated List of Essential Items for Reporting Diagnostic Accuracy Studies
Authors: Bossuyt Patrick M , Reitsma Johannes B , Bruns David E , Gatsonis Constantine A , Glasziou Paul P , Irwig Les , Lijmer Jeroen G , Moher David , Rennie Drummond , de Vet Henrica C W , Kressel Herbert Y , Rifai Nader , Golub Robert M , Altman Douglas G , Hooft Lotty , Korevaar Daniël A , Cohen Jérémie F 
Published: October 2015

Abstract
Incomplete reporting has been identified as a major source of avoidable waste in biomedical research. Essential information is often not provided in study reports, impeding the identification, critical appraisal, and replication of studies. To improve the quality of reporting of diagnostic accuracy studies, the Standards for Reporting of Diagnostic Accuracy Studies (STARD) statement was developed. Here we present STARD 2015, an updated list of 30 essential items that should be included in every report of a diagnostic accuracy study. This update incorporates recent evidence about sources of bias and variability in diagnostic accuracy and is intended to facilitate the use of STARD. As such, STARD 2015 may help to improve completeness and transparency in reporting of diagnostic accuracy studies.
Analysis Of Dynamic Replacement Column Construction Process On Neighbouring Engineering Structures
Authors: Łupieżowiec M. , Kanty P. 
Published: October 2015

Abstract
This paper presents the analysis of the influence of works related to the dynamic replacement column formation on the bridge pillar and the highway embankment located nearby. Thanks to DR columns, it is possible to strengthen the soil under road embankment in a very efficient way. However, the construction of such support carries risk to buildings and engineering structures located in the neighbourhood. Therefore modelling and monitoring of the influence of the conducted works should be an indispensable element of each investment in which dynamic replacement method is applied. The presented issue is illustrated by the example of soil strengthening with DR columns constructed under road embankment of DTŚ highway located in Gliwice. During the inspection, the influence of vibrations on the nearby bridge pillar and road embankment was examined. The acceleration values obtained during these tests were used to verify the elaborated numerical model.
Estimation Of Task Completion Times With The Use Of The PERT Method On The Example Of A Real Construction Project
Authors: Plebankiewicz E. , Juszczyk M. , Malara J. 
Published: October 2015

AbstractThe article presents briefly several methods of working time estimation. However, three methods of task duration assessment have been selected to investigate working time in a real construction project using the data collected from observing workers laying terrazzo flooring in staircases. The first estimation has been done by calculating a normal and a triangular function. The next method, which is the focus of greatest attention here, is PERT. The article presents a way to standardize the results and the procedure algorithm allowing determination of the characteristic values for the method. Times to perform every singular component sub-task as well as the whole task have been defined for the collected data with the reliability level of 85%. The completion time of the same works has also been calculated with the use of the KNR. The obtained result is much higher than the actual time needed for execution of the task calculated with the use of the previous method. The authors argue that PERT is the best method of all three, because it takes into account the randomness of the entire task duration and it can be based on the actual execution time known from research.
Enterprise’s Risk Assessment Of Complex Construction Projects
Authors: Konior J. 
Published: October 2015

AbstractThe purpose of this article is to present the preparation of Project Risk Assessment Methodology and its mitigation in complex construction projects. The main text provides a summary of the approach, the method used and the findings. The conclusions have been drawn that the proper tools for quantifying risks have to be based on the criteria specific for mathematical statistic and probability or at least fuzziness. Function, which makes possible to categorize any risks into one of the five categories, is a combination of probability and the impact on one of the items: people and their safety or budget, cost, schedule and planning or quality and performance. An attempt was made to express numerically the relationship between risks impacts and their level of likelihood. Also, a method of associating the influence of projects risks impacts on the extent of the likelihood of project risk occurrence which makes possible to determine the direction and the strength of this relationship was presented.
Random And Fuzzy Measure Of Unpredictable Construction Works
Authors: Konior J. 
Published: October 2015

Abstract
Supplementing well recognised practical models of project and construction management, based on probabilistic and fuzzy events may make possible to transfer the weight of the change and extra orders assessment from the qualitative form to a quantitative one. This assessment, however, is naturally burdened with an immeasurable, subjective aspect. Elaboration of probability of occurrence in a construction project unforeseen building works requires application (in addition to the non-measureable, qualitative criteria) of measurable (quantitative) criteria which still appear during construction project implementation. In reimbursable engineering contracts, a random event described as an extra, supplementary building work has a random character and occurs with a specific likelihood. In lump sum contracts, on the other hand, such a random event has a fuzzy character and its occurrence is defined in a linear manner by the function of affiliation to the set of fuzzy events being identical with unforeseen events. The strive for quantitative presentation of criteria regarded by nature as qualitative and the intention to determine relations between them led to the application of the fuzzy sets theory to this issue. Their properties enable description of the unforeseen works of construction projects in an unambiguous, quantitative way.
Isolation and recrystallization of epicuticular
waxes from Sorbus and Cotoneaster leaves
Authors: Ganeva Tsveta , Stefanova Miroslava , Koleva Dimitrina , Ruiz Segundo Ríos 
Published: October 2015

Abstract
Wax morphology and chemical composition
are widely accepted to be important for the protective
properties of the leaf’s surface and also valuable
characteristics in plant systematics. The leaves of Sorbus
domestica L. and Cotoneaster granatensis Boiss., species
of two large genera with intricate taxonomy referred
to subtribe Pyrinae, Rosaceae (formerly subfamily
Maloideae), were studied by scanning electron microscope
(SEM) and performing different methods of wax isolation.
The aim of the study was to acquire a suitable, cost and
time effective method for wax removal. Chloroform and
methanol extractions and freeze-embedding method
for direct isolation of the wax crystals were applied.
Immersing the leaves for 3 minutes in chloroform was
sufficient to extract the waxes whereas the efficiency of
the methanol solvent was lower. Wax layers with wellpreserved
structures of the crystals from both upper and
lower epidermis were successfully transferred to artificial
surfaces. The recrystallization experiment demonstrated
that waxes from chloroform extracts could recrystallize
in in vitro conditions on artificial surfaces. The crystals
showed same micromorphology as on the intact leaves.
Results of this study could be applied in further analytical
researches of the waxes of S. domestica and C. granatensis
or other species of the subtribe Pyrinae.
Application of PCR – RFLP markers for identification of genetically delimited groups of the Calypogeia fissa complex (Jungermanniopsida, Calypogeiaceae)
Authors: Buczkowska Katarzyna 
Published: October 2015

Abstract
Currently, two subspecies are formally recognized within Calypogeia fissa: C. fissa subsp. fissa occurring in Europe and C. fissa subsp. neogea known from North America. Genetic studies have revealed a complex structure of this species. Within the European part of distribution, three genetically distinct groups PS, PB and G are distinguished. The combination of the SCAR marker Cal04 and PCR-RFLP markers with three restriction enzymes (SmaI, TaqI and TspGWI) allowed the recognition of all groups within the C. fissa complex. The TaqI enzyme recognizing the restriction sites in the PCR product of SCAR marker Ca104 turned out to be the best marker
Screening of presumptive urinary tract infections by the automated urine sediment analyser sediMAX
Authors: Tessari Andrea , Osti Nicoletta , Scarin Marino 
Published: October 2015

AbstractUrinary tract infections (UTI) are among the most common bacterial infections and urine samples represent a large proportion of the specimens processed in clinical microbiology laboratories, up to 80% of which, however, yield negative results. Automated microscopy is widely used for urine sediment analysis and has recently been evaluated in a few studies for bacteriological screening of urine samples, achieving high levels of performance.We present a study in which urine samples from both inpatients and outpatients, with either clean-catch or indwelling catheter urine samples, were screened for UTI by urine culture, as the reference method, and the automated urine analyser sediMAX, for the detection of bacteria, leukocytes and yeasts.In total, 3443 urine samples were evaluated. When a single algorithm was adopted for sediMAX to screen the total patient population, 96.4% sensitivity, 75.4% specificity, 57.8% positive predictive value, and 98.4% negative predictive value were found. However, for male outpatients and all patients with indwelling catheter other algorithms were necessary to improve performances. Altogether, with sediMAX false negative rate was 2.4% and false positive rate was 27.6%. In addition, 54% of the investigated samples could have avoided urine culture.After the identification of specific algorithms for different patient subgroups, the automated urine analyser sediMAX can be reliably employed in the screening of UTI.
Soil-atmosphere relationships: The Hungarianperspective
Authors: Ács Ferenc , Rajkai Kálmán , Breuer Hajnalka , Mona Tamás , Horváth Ákos 
Published: October 2015

Abstract
This study discusses scientific contributions analyzingsoil-atmosphere relationships. These studies dealwith both the biogeophysical and biogeochemical aspectsof this relationship, with biogeophysical aspects beingin the majority. All of the studies refer either directly orindirectly to the fundamental importance of soil moisturecontent. Moisture has a basic influence on the spatiotemporalpattern of evapotranspiration, and so 1) oncloud formation and precipitation events by regulatingthe intensity of convection, and 2) on the trace-gas exchangesin the near-surface atmosphere. Hungarian modelingefforts have highlighted that soils in the PannonianBasin have region-specific features. Consequently, shallowand deep convection processes are also, to some extent,region-specific, at least in terms of the diurnal changeof the planetary boundary layer height and the spatial distributionof convective precipitation. The soil-dependentregion-distinctiveness of these two phenomena has beenrecognized; at the same time the strength of the relationshipshas not yet been quantified.
Dynamic viscoelastic properties of Chinese fir (Cunninghamia lanceolata) during moisture desorption processes
Authors: Zhan Tianyi , Jiang Jiali , Peng Hui , Lu Jianxiong 
Published: October 2015

AbstractThe viscoelasticity of Chinese fir (Cunninghamia lanceolata[Lamb.] Hook.) during moisture desorption processes were examined at 30°C and two relative humidity (RH) modes: RHramp-downmode from 85 to 0% RH, and RHisohumemode at 0, 30, and 60% RH, respectively. Dynamic viscoelastic properties were determined in a multi-frequency range of 1, 2, 5, 10, and 20 Hz. In both RH modes, desorption of water resulted in increasing stiffness and decreasing damping. The reduction in moisture content caused an unstable state in the cell wall due to the formation of free volumes in cell wall and rearrangement of hydrogen bonds within the polymer networks. Higher ramping rates resulted in greater destabilization, and the unstable state was more pronounced at a lower frequency. The ratio of storage modulus at 1 and 20 Hz remained unchanged during both RH modes. The ratios of loss modulus and loss factor at 1 and 20 Hz increased during the RHramp-downand decreased during the RHisohumeperiod. The changes of loss modulus or loss factor ratios at two frequencies were suitable for evaluation of the unstable state. The instability was aggravated with reducing RH and slightly recovered at constant RH.
Generalized co-annihilator of BL-algebras
Authors: Meng Biao Long , Xin Xiao Long 
Published: October 2015

Abstract
In BL-algebras we introduce the concept of generalized co-annihilators as a generalization of coannihilator
and the set of the form x-1F where F is a filter, and study basic properties of generalized co-annihilators.
We also introduce the notion of involutory filters relative to a filter F and prove that the set of all involutory
filters relative to a filter with respect to the suit operations is a complete Boolean lattice and BL-algebra. We use
the technology of generalized co-annihilators to give characterizations of prime filters and minimal prime filters,
respectively. In particular, we give a representation of co-annihilators in the quotient algebra of a BL-algebra L via
a filter F by means of generalized co-annihilators relative to F in L: