bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photogrammetry and 3D Imaging System for Subsea Systems Inspection - Mooring Inspection on P-51
Authors: Heitich Leila Valladares , Batista Da Silva João Luis , Gomes dos Santos Christian Ramalho , dos Anjos Christiano Marino Lucas , de Souza Queiroz Wesley 
Published: August 2024

Abstract
Petrobras foresees a scenario, in 2025, of extensive utilization of FPSOs in production activities in the Brazilian pre-salt. Besides future installations, Petrobras has an extensive mature oil and gas production fleet, some of which will be decommissioning in the following years. Mooring line inspection quality and reliability are of utmost importance in assessing mooring systems integrity, supporting decision making and risk management during design life (e.g., anticipating line breakage, avoiding loss of position and disruptions in production). In more mature systems, accurate information can improve in the planning about parallel decommissioning projects. In this way more accurate and reliable inspection methods using 3D laser imaging and photogrammetry are being sought, enabling remote Diverless applications and creating highly accurate 3D models. In addition to improving result reliability, this technological innovation also makes it possible to evolve towards solutions with Digital Twins and artificial intelligence, further developing the integrity assessment of mooring systems. At the end of 2022, a pilot test with one of these technologies was conducted on one of mooring lines. This article aims to reveal the results and discusses next steps, bringing potential benefits as man-hours risk exposure reduction and result reliability.
Digital Twin for Offshore Windfarm Jacket Lifting Frame
Authors: Mali Vijaykumar 
Published: August 2024

Abstract
Wind turbine capacity is increasing every year with new innovations and so does the size of wind turbine jacket foundations. This paper presents the development of a Structural digital twin solution for a physical asset, namely the ‘lifting frame arrangement’ that is designed for up-righting wind farm jackets from a horizontally built condition to a vertical condition in a construction yard. The lifting frame arrangement is a crane-type structure with a fixed foundation, a fixed boom structure, and strand jacks mounted at the tip of the booms. The lifting frame is designed, fabricated, installed, operated, and maintained with strategic objectives to reduce the cost, schedule, and project risks.
The operational safety and structural integrity of the lifting frame system during the up-righting of jackets, were assured through several detailed design substantiation processes, which included certification by DNV. If we consider capital expenditure (CAPEX) cost as USD X Millions, then operating expenditure (OPEX) cost is about 0.05X Millions USD. OPEX cost of the lifting infrastructure increases at incremental rate year on year once the asset approaches its design life. Structural digital twin of the lifting frame has minimized OPEX costs by 50% while assuring the structural integrity of the complete system by near real time monitoring of asset health. This structural digital twin solution may also enable the enhancement in the capacity of the lifting frame, by revisiting the design safety factors based on the operational history and measured stresses and reactions, ensuring that the lifting frame becomes suitable for upending heavier jackets than designed.
This paper illustrates the stepwise details followed to develop the digital twin solution; the sensors used for monitoring operations as well as the status of the structural health of the lifting frame during operation. The reduced basis finite element analysis (RB-FEA-[2]) was followed using Akselos’ software for near real time integration of sensor data with analysis model.
Engagement of Peer Educators from India’s National Adolescent Health Programme for the COVID-19 response activities: Qualitative findings from i-Saathiya study
Authors: Bassi Shalini , Bahl Deepika , Maity Heeya , Dringus Stefanie , Rizvi Zoya Ali , Kumar Deepak , Raina Agrima , Arora Monika 
Published: August 2024

BackgroundThe COVID-19 pandemic strained India’s healthcare system and health workers unprecedentedly.PurposeThe extent of the contribution by peer educators (PEs) from India’s National Adolescent Health Programme-Rashtriya Kishor Swasthya Karyakram (RKSK) to COVID-19 response activities remains uncertain necessitating an imperative investigation. Within the overarching objective of the ‘i-Saathiya’ study (‘i’ signifies implementation science and Saathiya represents PEs in Madhya Pradesh), a key focus was to understand the role of PEs recruited under RKSK during COVID-19 in two Indian states, namely Madhya Pradesh and Maharashtra. The study states differ in sociodemographic characteristics and peer education implementation models.MethodsIn-depth interviews (IDIs) were conducted with stakeholders (n=110, Maharashtra: 57; Madhya Pradesh: 53) engaged in the implementation of RKSK’s peer education programme at state, district, block and village levels. Focus group discussions (FGDs) (n=16 adolescents, Maharashtra: 8; Madhya Pradesh: 8) were conducted with adolescents, part of the peer group of PEs (n=120 adolescents, Maharashtra: 66; Madhya Pradesh: 54). IDIs and FGDs were audio-recorded, translated, transcribed verbatim and analysed thematically. Adopting inductive and deductive approaches, a data-driven open coding framework was developed for thematic analysis.ResultsThe PE recruited under RKSK took a central role that extended beyond their predefined responsibilities within the RKSK. They provided crucial support to healthcare workers in curbing the spread of COVID-19. Their diverse contributions, including COVID-19 pandemic response support, addressing community and adolescent needs, role in COVID-19 vaccination efforts, navigating access to the health system and facilitating health workers in the implementation of various national health programmes and campaigns during COVID-19.ConclusionThe findings underscore the potential of PEs in bolstering the health system. Despite their unpreparedness for the context (COVID-19), PEs demonstrated tenacity and adaptability, extending their roles beyond their predefined responsibilities. Recognising PEs through awards and incentives, skill courses and additional grades, can enhance their visibility, sustaining impactful work within RKSK and beyond.
Epidemiology and health care of hyperhidrosis in Germany: claims data analysis
Authors: Hagenström Kristina , Müller Katharina , Ohm Frenz , Augustin Matthias 
Published: August 2024

Background and objectivesData on the population-based epidemiology of hyperhidrosis (HH) are scarce. This study investigated the epidemiology and healthcare of HH in Germany.Design and settingClaims data of adult persons insured by a German statutory health insurance (DAK-Gesundheit) between 2016 and 2020 were analysed. Included were persons aged 18 years and older with a diagnosis of HH (confirmed inpatient or outpatient diagnosis in the observation year) who were continuously insured. Following outcomes were measured: prevalence and incidence rates, severity of hyperhidrosis and inpatient and outpatient care by a group of specialists.ResultsIn 2020, 0.70% of insured adults were confirmed to have HH (mean age 59.5 years, SD 18.9, 61.6% female), with 9.24% having a ‘localised’ form, 8.65% a ‘generalised’ form and 84.80% an ‘unspecified’ form. 0.04% of the total population had a severe form. The incidence was 0.35%. Localised HH was more common in younger age groups (18 to <30 years), while older age groups (70 to <80 years) were significantly more likely to suffer from generalised HH. Systemic anticholinergics were used in 4.55%, and botulinum toxin injection therapy in 0.81%. General practitioners were most frequently involved in care. Inpatient stays due to HH were very rare, with 0.14% in 2019 and 0.04% in 2020.ConclusionMultisource data analysis connecting primary and secondary data will be needed for a complete picture of the healthcare and epidemiology of HH.
Gene panel predicts neoadjuvant chemoimmunotherapy response and benefit from immunotherapy in HER2-negative breast cancer
Authors: Lu Xunxi , Gou Zongchao , Chen Hong , Li Li , Chen Fei , Bao Chunjuan , Bu Hong 
Published: August 2024

BackgroundIt is encountering the dilemma of lacking precise biomarkers to predict the response to neoadjuvant chemoimmunotherapy (NACI) and determine whether patients should use immune checkpoint inhibitors (ICIs) in early breast cancer (BC). We aimed to develop a gene signature to predict NACI response for BC patients and identify individuals suitable for adding ICIs.Patients and methodsTwo I-SPY2 cohorts and one West China Hospital cohort of patients treated with NACI were included. Machine learning algorithms were used to identify key genes. Principal component analysis was used to calculate the ImPredict (IP) score. The interaction effects between biomarkers and treatment regimens were examined based on the logistic regression analysis. The relationship between the IP score and immune microenvironment was investigated through immunohistochemistry (IHC) and multiplex IHC.ResultsThe area under the curves of the IP score were 0.935, 0.865, and 0.841 in the discovery cohort, validation cohort 1, and in-house cohort. Marker-treatment interaction tests indicated that the benefits from immunotherapy significantly varied between patients with high and low IP scores (p for interaction <0.001), and patients with high IP scores were more suitable for immunotherapy addition.ConclusionsOur IP model shows favorable performance in predicting NACI response and is an effective tool for identifying BC patients who will benefit from ICIs. It may help clinicians optimize treatment strategies and guide clinical decision-making.
Sex-specific association of cardiovascular drug doses with adverse outcomes in atrial fibrillation
Authors: Moor Jeanne , Kuhne Michael , Moschovitis Giorgio , Kobza Richard , Netzer Seraina , Auricchio Angelo , Beer Juerg H , Bonati Leo , Reichlin Tobias , Conen David , Osswald Stefan , Rodondi Nicolas , Clair Carole , Baumgartner Christine , Aubert Carole Elodie 
Published: August 2024

ObjectivesSex differences occur in atrial fibrillation (AF), including age at first manifestation, pathophysiology, treatment allocation, complication rates and quality of life. However, optimal doses of cardiovascular pharmacotherapy used in women with AF with or without heart failure (HF) are unclear. We investigated sex-specific associations of beta-blocker and renin–angiotensin system (RAS) inhibitor doses with cardiovascular outcomes in patients with AF or AF with concomitant HF.MethodsWe used data from the prospective Basel Atrial Fibrillation and Swiss Atrial Fibrillation cohorts on patients with AF. The outcome was major adverse cardiovascular events (MACEs), including death, myocardial infarction, stroke, systemic embolisation and HF-related hospitalisation. Predictors of interest were spline (primary analysis) or quartiles (secondary analysis) of beta-blocker or RAS inhibitor dose in per cent of the maximum dose (reference), in interaction with sex. Cox models were adjusted for demographics, comorbidities and comedication.ResultsAmong 3961 patients (28% women), MACEs occurred in 1113 (28%) patients over a 5-year median follow-up. Distributions of RAS inhibitor and beta-blocker doses were similar in women and men. Cox models revealed no association between beta-blocker dose or RAS inhibitor dose and MACE. In a subgroup of patients with AF and HF, the lowest hazard of MACE was observed in women prescribed 100% of the RAS inhibitor dose. However, there was no association between RAS dose quartiles and MACE.ConclusionsIn this study of patients with AF, doses of beta-blockers and RAS inhibitors did not differ by sex and were not associated with MACE overall.
SIMUnet: an open-source tool for simultaneous global fits of EFT Wilson coefficients and PDFs
Authors:   PBSP Collaboration, Costantini Mark N. , Hammou Elie , Kassabov Zahari , Madigan Maeve , Mantani Luca , Morales-Alvarado Manuel , Moore James M. , Ubiali Maria 
Published: August 2024

AbstractWe present the open-source code, designed to fit Standard Model Effective Field Theory (SMEFT) Wilson coefficient alongside Parton Distribution Functions (PDFs) of the proton. can perform SMEFT global fits, as well as simultaneous fits of the PDFs and of an arbitrarily large number of SMEFT degrees of freedom, by including both PDF-dependent and PDF-independent observables. can also be used to determine whether the effects of any New Physics models can be fitted away in a global fit of PDFs. is built upon the open-source code and is released together with documentation, and tutorials. To illustrate the functionalities of the new tool, we present a new global analysis of the SMEFT Wilson coefficients accounting for their interplay with the PDFs. We increment our previous analysis of the LHC Run II top quark data with both (i) the Higgs production and decay rates data from the LHC, and (ii) the precision electroweak and diboson measurements from LEP and the LHC.
Neutrino masses from new seesaw models: low-scale variants and phenomenological implications
Authors: Giarnetti Alessio , Herrero-García Juan , Marciano Simone , Meloni Davide , Vatsyayan Drona 
Published: August 2024

AbstractWith just the Standard Model Higgs doublet, there are only three types of seesaw models that generate light Majorana neutrino masses at tree level after electroweak spontaneous symmetry breaking. However, if there exist additional TeV scalars acquiring vacuum expectation values, coupled with heavier fermionic multiplets, several new seesaw models become possible. These new seesaws are the primary focus of this study and correspond to the tree-level ultraviolet completions of the effective operators studied in a companion publication. We are interested in the genuine cases, in which the standard seesaw contributions are absent. In addition to the tree-level generation of neutrino masses, we also consider the one-loop contributions. Furthermore, we construct low-energy versions that exhibit a very rich phenomenology. Specifically, we scrutinise the generation of dimension-6 operators and explore their implications, including non-unitarity of the leptonic mixing matrix, non-universal $$Z-$$

Z
-

boson interactions, and lepton flavor violation. Finally, we provide (Generalised) Scotogenic-like variants that incorporate viable dark matter candidates.
Echoes of Veltman criteria on the next-two-Higgs-doublet model
Authors: Arhrib Abdesslam , Benbrik Rachid , Rahili Larbi , Semlali Souad , Taki Bassim 
Published: August 2024

AbstractWe investigate how the Next-Two-Higgs Doublet Model extension (N2HDM) should look if we are to address the naturalness problem using dimensional regularization. In such a model, new Higgs states are predicted, namely: three CP-even $$h_{1,2,3}$$

h

1
,
2
,
3

, one CP-odd A, and a pair of charged Higgs boson $$H^\pm $$

H
±

. Our calculations of the overall quadratic divergences have been performed with full consistency with the latest data from the Large Hadron Collider (LHC) concerning the observed 125 GeV Higgs boson, alongside precision electroweak data tests and lower mass limits on charged Higgs boson. It is shown that the quadratically divergent quantum corrections $$\delta _i$$

δ
i

(i=1,2,3) for the three CP-even Higgs bosons are controllably small, though hidden fine-tuning might still be required. This reveals a significant impact on the model parameter space, Higgs spectrum mass and notably the singlet-doublet admixture.
The CCR6–CCL20 Axis Promotes Regulatory T-cell Glycolysis and Immunosuppression in Tumors
Authors: Pant Ayush , Jain Aanchal , Chen Yiyun , Patel Kisha , Saleh Laura , Tzeng Stephany , Nitta Ryan T. , Zhao Liang , Wu Caren Yu-Ju , Bederson Maria , Wang William Lee , Bergsneider Brandon Hwa-Lin , Choi John , Medikonda Ravi , Verma Rohit , Cho Kwang Bog , Kim Lily H. , Kim Jennifer E. , Yazigi Eli , Lee Si Yeon , Rajendran Sakthi , Rajappa Prajwal , Mackall Crystal L. , Li Gordon , Tyler Betty , Brem Henry , Pardoll Drew M. , Lim Michael , Jackson Christopher M. 
Published: August 2024

Abstract
Regulatory T cells (Treg) are important players in the tumor microenvironment. However, the mechanisms behind their immunosuppressive effects are poorly understood. We found that CCR6–CCL20 activity in tumor-infiltrating Tregs is associated with greater glycolytic activity and ablation of Ccr6 reduced glycolysis and lactic acid production while increasing compensatory glutamine metabolism. Immunosuppressive activity toward CD8+ T cells was abrogated in Ccr6−/− Tregs due to reduction in activation-induced glycolysis. Furthermore, Ccr6−/− mice exhibited improved survival across multiple tumor models compared to wild-type mice and Treg and CD8+ T-cell depletion abrogated the improvement. In addition, Ccr6 ablation further promoted the efficacy of anti-PD-1 therapy in a preclinical glioma model. Follow-up knockdown of Ccl20 with siRNA also demonstrated improvement in antitumor efficacy. Our results unveil CCR6 as a marker and regulator of Treg-induced immunosuppression and identify approaches to target the metabolic determinants of Treg immunosuppressive activity.
Limitations of 2-dimensional line-scan MRI for directly measuring neural activity
Authors: Wilson Joshua M. , Wu Hua , Kerr Adam B. , Wandell Brian A. , Gardner Justin L. 
Published: August 2024

Abstract
A 2D-line-scan MRI sequence has been reported to directly measure neural responses to stimuli (the “DIANA response”). Attempts to replicate the DIANA response have failed, even with higher field strength and more repetitions. Part of this discrepancy is likely due to a limited understanding of how physiological noise manifests in 2D-line-scan acquisition sequences. Specifically, it is unclear what the consequences are of breaking the assumption that the imaging substrate remains constant between each line acquisition. To answer this question, we collected 2D-line-scan data at 3T from human subjects viewing a blank screen. We found temporal fluctuations in the reconstructed time series that could easily be confused with neural responses to stimuli. These fluctuations were present both in the head and in the surrounding empty volume along the span of the phase-encoding direction from the head. The timing of these fluctuations varied systematically and smoothly along the phase-encoding direction. These artifacts are similar to well-known phase-encoding artifacts in EPI and GRE images, but are exacerbated due to longer acquisition times in the 2D-line-scan sequence (seconds vs. milliseconds). We explain these artifacts with a model that accounts for the acquisition sequence and incorporates time-varying contrast fluctuations and movement in the imaging substrate. Using the model, we quantify the amount of cortical- and scan-averaging one might need to reliably distinguish a DIANA response from noise, and show that navigator echoes might help in reducing phase-encode noise in the 2D-line-scan sequence.
Toward an Understanding of a Misconceived Igbo Deity
Authors: Onah Tobias Chibuike , Uwaegbute Kingsley Ikechukwu , Eze Virginus Uchenna 
Published: August 2024

Abstract
This ethnographic study investigates the misconception among Christians and adherents of African Traditional Religion in their view and understanding of the deity ‘ekwensu’, commonly called Satan in Christian theology. The study area is Nsukka, a culture area in Nigeria. The adherents of the two religions use the words ‘Satan’ and ‘devil’ for ekwensu interchangeably. Many Christians claim that Satan is the sole equivalent of the traditional deity ekwensu in the Igbo cosmology. The aim of the work is to compare the Christian views of ekwensu as Satan, bringing out the origin, attributes, and activities of the two concepts ekwensu and Satan. The findings show significant differences between Satan and ekwensu, that Satan and ekwensu vary in their origin and attributes, and that they have different geographical locations. It is shown that some shrines and forests were dedicated to the ekwensu deity in Nsukka, and that masquerades also honour the festival of ekwensu (afor ekwensu). It is also evident that Christianity had a significant impact on the culture of the Nsukka people, which engendered the misconception of the ekwensu deity. This was partly based on Igbo Christian theolinguistics occasioned by Christian missionary activities in the area.
Aerosol-Induced Changes in Atmospheric and Oceanic Heat Transports in the CESM2 Large Ensemble
Authors: Needham Michael R. , Cox Tyler , Randall David A. 
Published: August 2024

Abstract
The total poleward energy transport (PET) is set by the top of atmosphere radiation flux and is therefore sensitive to any process which can alter those fluxes, particularly in the shortwave. One example is the direct and indirect effects of anthropogenic aerosols, which increase the local reflection of solar radiation back into space. The historic emission of sulfur dioxide, which peaked in the northern midlatitudes during the 1980s, has been proposed as a primary contributor to historic anomalies in cross-equatorial energy transport, as well as related processes such as a shift in the tropical rainband. In this study, we analyze simulations from the Community Earth System Model, version 2 (CESM2), large ensemble and single-forcing projects to better understand the forced response of PET to historical forcings. First, analysis of the single-forcing project reveals that the position of the intertropical convergence zone (ITCZ) responds in a nonlinear manner to greenhouse gas forcing in CESM2. This type of nonlinearity has been found previously in the context of the aerosol-only simulations in the CESM2 single-forcing project but may be the first identification of a similar effect in the greenhouse gas–only simulations. Second, through analysis of the full CESM2 large ensemble simulations, we find that anomalous heat transport occurred in both the atmosphere (through the mean meridional circulation and atmospheric eddies) and the oceans (through the Atlantic and Indo-Pacific sectors) due to a variety of related processes including the Hadley cells, the midlatitude storm tracks, the Atlantic meridional overturning circulation (AMOC), and the Pacific wind-driven subtropical gyre.

Significance Statement
In this study, we investigate how the Earth system changed the transport of energy from the tropics to the poles in response to historic pollution. We analyze a large number of climate model simulations of the recent past (1850 to present) and find that historic emissions of sulfur dioxide caused the model to transport more energy in the form of stronger ocean currents, stronger storms, and stronger prevailing winds. This is because the modeled currents in the Atlantic were too sensitive to historic pollution and transported too much warm water northward.