bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bottom-Up Liquid Chromatography–Tandem Mass Spectrometry Method for Therapeutic Drug Monitoring of Infliximab: Method Development, Comparison With 2 Enzyme-Linked Immunosorbent Assay Methods, and Evaluation of Anti-Drug Antibody Interference
Authors: Kim Sang-Mi , Oh Hyeonju , Hong Sung Noh , Kim Mi Jin , Choe Yon Ho , Lee Soo-Youn 
Published: July 2024

Context.—
Therapeutic drug monitoring is recommended to optimize infliximab use and improve outcome in chronic inflammatory disorders.

Objective.—
To describe a simple and affordable liquid chromatography–tandem mass spectrometry (LC-MS/MS) method to measure inﬂiximab in serum.

Design.—
Infliximab was measured using winged stable isotope–labeled peptides as internal standards. Linearity, lower limit of measuring interval, limit of detection, precision, accuracy, carryover, and ion suppression were evaluated. Method comparison against 2 enzyme-linked immunosorbent assay (ELISA) methods (Remsima Monitor and IDKmonitor Infliximab) and anti-drug antibody (ADA) interference were evaluated using clinical specimens from inflammatory bowel disease patients (N = 237).

Results.—
Analytical run time and sample preparation time were 5 minutes per sample and 3 hours per batch, respectively. Analytical measurement interval and limit of detection were 0.50 to 50.0 μg/mL (R2 = 0.998) and 0.25 μg/mL, respectively. The intraday and interday imprecision percentage coefficients of variation were less than 6.1%. Accuracy was 94.2% to 98.7%. No significant ion suppression or carryover was observed. Infliximab concentrations measured by LC-MS/MS showed good agreement with those measured by Remsima Monitor (mean percentage difference, 5.7%; 95% CI, −1.2% to 12.6%) but were markedly lower than those measured by IDKmonitor (−32.6%; −35.8% to −29.4%), demonstrating significant bias between ELISAs. Although a good agreement between LC-MS/MS and ELISA was observed for ADA-negative samples (−3.5%; −12.8% to 5.9%), a significant bias was observed for ADA-positive samples (13.6%; 1.7% to 25.6%).

Conclusions.—
This simple, fast, and affordable LC-MS/MS method for inﬂiximab quantitation could improve standardization of infliximab quantitation and optimization of infliximab use in patients with high-titer ADA.
The Image of Mafraq in the Geographers' and Travelers' Books and the Books of the Stations of Pilgrimage. (Since the Umayyad Era till the End of the Ottoman Era)
Authors: Al-Rawadieh Al-Mahdi 
Published: July 2024

The cities and places located on the route of the pilgrims of the Levant were taken care of by Arab and Muslim geographers and travelers, their blogs included a description of their geographical nature and general conditions in terms of water resources and the availability of food, the fodder necessary to feed the animals, and the state of the roads that penetrate or pass next to it in terms of security and difficulty of passage and other things that the traveler should beware of such as thieves and bandits. The books of the pilgrimage also included brief statements aimed at serving the pilgrim and informing him of the route of the road and the conditions of the places located on it.
Mafraq (its ancient name: Al-Faddain) occupied an important place before Islam by being located on the ancient Sultanic road (Trajan's road). Its flat terrain contributed to making it a corridor preferred by travelers away from the desert routes to the East, and The Straits of the Ajloun mountains to the West.
This paper aims to trace the descriptions of Arab geographers and travelers about Mafraq (Al-Faddain) and note its presence in their writings and in the works of the pilgrimage stations, and to indicate their impressions of it and its geographical location.
Lover’s Joy for Being Named with a Self–Associated Authored by the chief justice Jamal al-Din Abi Al-Mahasin Muhammad Bin Ali Bin Abi Bakr al-Qurashi Al-abdiri Al-Shibi Al-Makki Al-Shafi'i, who died in (837 AH/1433 AD) (Investigation and Study)
Authors: Almhirat Raed , Alkhrisha Rad 
Published: July 2024

The present study deals with the investigation and study of the book “Lover’s Joy for Being Named with a Self–Associate”, by the chief justice Jamal al-Din Abu Al-Mahasin Muhammad Bin Ali Bin Abi Bakr al-Qurashi Al-abdiri Al-Shibi Al-Makki Al-Shafi'i, who died in (837 AH/1433 AD). The book is delicate in its size, rare in its field, The author distinguished it by getting it translated by more than twenty famous figures who had nicknames related to their bodies either for a congenital defect in one of them, or for a congenital advantage that distinguished them from others, it is as well a second-to-none analog in our Arab heritage.
The nature of the research required it to come in two sections, first: the study; it came in two chapters, where in the first one the author was highlighted, and in the second we studied the book. The second section is the verified text, followed by a list of sources and references to which we have returned.
Memahami Tantangan dan Solusi Quarter-Life Crisis dalam Perspektif Psikologi Sosial
Authors: Ardayu Fadila Hamzah  , Abu Bakar Fahmi  , Muhammad Abdul Halim Sani  
Published: July 2024

This research aims to understand the challenges and solutions faced by young adults experiencing a quarter-life crisis (QLC) from a social psychology perspective. The method used is a case study involving individuals aged 20-30 years. The results show that QLC is a period of significant crisis, characterized by uncertainty and anxiety regarding career, interpersonal relationships, and self-identity. The main causal factors include social pressure, comparison of oneself with others, and family and environmental expectations. The psychological impacts that arise include feelings of being trapped, anxiety, and depression, which affect an individual's mental and emotional well-being. This research identified four main stages in QLC: feelings of being trapped, the urge to change the situation, efforts to rebuild life, and finally achieving control and life satisfaction. Effective solutions to overcome QLC include psychological interventions such as solution-focused therapy, limiting social media use, and developing a strong social support network. Better self-understanding and focusing on concrete actions are also important strategies in dealing with uncertainty and anxiety during this period. This research provides important insights for psychology practitioners and individuals facing QLC, and emphasizes the need for interventions tailored to each individual's specific needs. With the right support, individuals can manage QLC more effectively and achieve a more stable and fulfilling life.
Exploring attributes impeding students’ classroom oral interactions and participation in EFL classes: Kotebe University of Education in Focus
Authors: Motuma Fisseha ,   Kotebe University of Education, Addis Ababa, Ethiopia
Published: July 2024

This study explores the attributes impeding students’ classroom oral interaction and participation in EFL classes. Descriptive survey research design was employed to carry out the study. The research included fifty (50) students out of 148 target population, which is 33.8%. It also involved twelve English language instructors out of 34 members using a convenient sampling technique. As the student population was grouped into sections, stratified and random systematic sampling techniques were employed to determine the specific representative samples. Data were collected using a questionnaire, semi-structured interview, and rating scale. The collected data were analyzed using mixed research methods (qualitative and quantitative approaches). The result reveals that eleven classroom oral interaction and participation-impeding attributes are found to be rated by more than 50% of the respondents. Most of the identified attributes are allied to teachers’ and students’ personal perceptions, lesson delivery styles, learning topics, fear of criticism, external pressures, classroom social impacts, lack of prior experience, and overuse of mother tongue as a way out of English speaking stress. It was concluded that most impeding classroom attributes were found to be rooted in psychological, social, pedagogical, linguistic, and communicative competencies.
تأثير الرش بمستخلص الطحالب البحرية والارجنين والبراسينولايد في المحتوى الكيميائي لنباتات الشليك صنف Albion
Authors: الدليمي أحمد , العلياوي زياد 
Published: July 2024

نفذت الدراسة في محافظة الانبار وبموقعين الاول المحطة البحثية الاولى التابعة لكلية الزراعة - جامعة الانبار، أما الموقع الثاني قرية الدولاب وذلك لموسم النمو 2022-2023، بهدف البحث في تأثير الرش بكل من مستخلص الطحالب البحرية والحامض الاميني الارجنين ومنظم النمو البراسينولايد في نمو وانتاج نباتات الشليك صنف Albion تحت ظروف البيئة المحمية. وتم استخدام مستخلص الطحالب البحرية بثلاثة مستويات 0، 2، 4 مل لتر-1، أما الحامض الأميني الارجنين فقد تم رشه على النباتات بثلاثة تراكيز 0، 100، 200 ملغم لتر-1، فيما استخدم منظم النمو البراسينولايد بثلاثة تراكيز 0، 0.05، 0.10 ملغم لتر-1. ونفذت تجربة عاملية بثلاثة عوامل وذلك وفقا لتصميم القطاعات العشوائية الكاملة، وقد تكونت التجربة من 27 معاملة بواقع ثلاث قطاعات و5 مكررات لكل وحدة تجريبية. حللت البيانات إحصائياً، وقورنت المتوسطات باستعمال اختبار اقل فرق معنوي (L.S.D.) وعلى مستوى احتمال 0.5% . ولقد أظهر الرش بمستخلص الطحالب البحرية تأثيرا معنويا في كافة الصفات المدروسة، وقد أسهم التركيز (4 مل لتر-1) في تحقيق أفضل النتائج للصفات وبلغت (11.78 و11.13 ملغم غم-1، 13.82 و12.83%، 2.50 و2.40%، 0.184 و0.176%، 1.64 و1.60%) وذلك للصفات (محتوى الأوراق من الكلوروفيل والكربوهيدرات وعناصر N وP وK) للموقعين الأول والثاني وبلغت على التتابع. أما فيما يتعلق بتأثير الرش بالحامض الأميني (الارجنين) على نباتات الشليك صنف (Albion) فقد بلغ مستوى المعنوية ولكافة الصفات المدروسة، وقد حقق التركيز (200 ملغم لتر-1) أفضل النتائج للصفات (محتوى الأوراق من الكربوهيدرات وعناصر N وP وK) وذلك للموقعين الأول والثاني وبلغت (13.91 و12.53%، 2.48 و2.37%، 0.183 و0.176%، 1. 59 و1. 61%) على التتابع، أما صفة محتوى الأوراق من الكلوروفيل فقد ظهرت بأعلى مستوياتها عند التركيز (100 ملغم لتر-1) وبلغ عند كلا الموقعين على التتابع (11.68 و10.69 ملغم غم-1). ومن جهة اخرى فقد أوضحت النتائج ان معاملات الرش بمنظم النمو (Brassinosteroid) أثر معنويا في كافة الصفات المدروسة باستثناء محتوى الأوراق من الكربوهيدرات وللموقعين، وقد أسهم التركيز (0.10 ملغم لتر-1) في تحقيق أفضل النتائج للصفات (محتوى الأوراق من الكلوروفيل وعناصر N وP وK) وبلغت (11.87 و10.71 ملغم غم-1، 2.48 و2.37%، 0.180 و0.172%، 1.56 و1.56%) وذلك عند كلا موقعي الدراسة على التتابع. ومن جهة اخرى حقق التركيز أعلاه أعلى القيم لصفة محتوى الأوراق من الكربوهيدرات عند الموقع الأول وبلغت 13.88%. أما فيما يتعلق بالتداخلات الثنائية والثلاثية بين عوامل الدراسة فقد بلغت مستوى المعنوية وذلك تبعا لنوع الصفة المدروسة.
توظيف استراتيجية SWOM في تدريس الرياضيات واثرها في تحصيل طالبات الصف الاول متوسط
Authors: صالح عمار 
Published: July 2024

يهدف البحث الحالي إلى التعرّف على توظيف استراتيجية SWOM في تدريس الرياضيات واثرها في تحصيل طالبات الصف الاول متوسط، وللتأكد من هدف البحث وضع الباحث الفرضية الصفرية الرئيسية التي مفادها لا يوجد فرق ذو دلالة إحصائية عند مستوى الدلالة (0.05) بين متوسط درجات تحصيل طالبات المجموعة التجريبية اللواتي درسنّ وفق استراتيجية SWOM ومتوسط درجات تحصيل طالبات المجموعة الضابطة اللواتي درسنّ وفق الطريقة الاعتيادية في الاختبار التحصيلي .تكونت عينة البحث من (71) طالبة من طالبات الصف الاول المتوسط من ثانوية (الشروق) تم توزيعهن عشوائياً وبواقع (36) طالبة للمجموعة التجريبية التي درست على وفق استراتيجية SWOM و(35) طالبة للمجموعة الضابطة التي درست بالطريقة الاعتيادية، وتمت مكافأتهم في متغيرات (التحصيل الدراسي السابق في مادة الرياضيات السادس الابتدائي، والخبرة السابقة، مستوى الذكاء). وفي ضوء ما توصل اليه البحث من نتائج وضع الباحث عدداً من الاستنتاجات والتوصيات و المقترحات و منها أن فاعلية SWOM في تدريس مادة الرياضيات ورفع مستوى تحصيل الطالبات للمعلومات مقارنة بالطريقة الاعتيادية كما تم اقتراح إجراء دراسة لفاعلية استراتيجية SWOM في تنمية التفكير الهندسي لدى طالبات الصف الاول المتوسط في مادة الرياضيات
Ebeveyn- Çocuk İlişkileri Bağlamında Annelerin Görüşlerinin Belirlenmesi
Authors: Tavukçuoğlu Havva 
Published: July 2024

Bu araştırmanın amacı ebeveyn- çocuk ilişkileri bağlamında annelerin görüşlerinin belirlenmesidir. Nitel yöntemin kullanıldığı çalışmada katılımcılara yarı yapılandırılmış görüşme formu uygulanmıştır. Çalışma grubunu Kuzey Kıbrıs Lefkoşa’da yaşamakta olan 10- 13 yaş aralığında çocuk/çocuklara sahip olan 20 anne oluşturmaktadır. Bu araştırmada annelerin görüşleri yarı yapılandırılmış sorular aracalığıyla toplandığı için, verilerin analizinde bir nitel veri analizi olan, içerik analiz yöntemi benimsenmiştir. Elde edilen verilerin analizi için nitel analiz programı olan MAXQDA 2020 programı kullanılmıştır. annelerin görüşlerine göre çocuğun eğitimi, gelişimi vb. Konulardan daha çok annelerin sorumlu olduğu sonucuna ulaşılmıştır. Annelerin görüşlerine göre iyi çocukluğun anlamına yönelik çocuklarının mutlu olması, huzurlu olması, ebeveynlerce kaliteli zaman geçirilmesi anneler için iyi çocukluk anlamına gelmektedir. Annelerin görüşlerine göre çocukları iyi bir çocukluk geçirmektedirler. Bunun yanı sıra araştırmaya katılan bazı anneler çocuklarının kısmen iyi bir çocukluk geçirdiklerini belirtmiştir. Annelerin çocuklarına yönelik beklentileri iyi iş sahibi olması, saygılı, sevgili ve başarılı olmaıs, mutlu yuvası olması, mutlu olması, anne-baba ile ilgilenmesidir. Annelerin görüşlerine göre çocukları ile iletişimlerinin güçlü olarak açıklandığı ifade edilebilir. Ebeveyn- çocuk ilişkisini güçlendirmek adına yapılabileceklere yönelik kaliteli zaman geçirme anne görüşlerine göre en etkili yöntemdir. Bunun yanı sıra annelerin görüşlerine göre; olumlu iletişim kurmak, güvenli ortam yaratmak ve dinlemek ebeveyn- çocuk ilişkisini güçlendirebilir. Annelerin görüşlerine göre çocukları ile yaşadıkları güçlük sıklıkla iletişimdir. Ebeveyn- çocuk ilişkisinde yaşanan güçlükler için ihtiyaç duyulan desteklereyönelik anne görüşlerinde ebeveynler için eğitim verilmesi ihtiyaç duyulan desteklerde ilk sırada yer almaktadır.
An Examination of Organizational Development at FTIK UIN KH Abdurrahman Wahid Pekalongan From the Viewpoint Of Stakeholders And The Academic Community
Authors: Solehudin Moch. Sugeng , Jaeni Muhamad , Sopiah Sopiah , Khobir Abdul 
Published: July 2024

This study is descriptive qualitative research. From the academic community's and stakeholders' viewpoint, this study identifies the critical areas for developing the Faculty of Tarbiyah and Teacher Training Sciences of K.H. Abdurrahman Wahid State Islamic University Pekalongan. To determine the answers to the issues with organizational development facing the Faculty of Tarbiyah and Teacher Training Sciences at K.H. Abdurrahman Wahid State Islamic University Pekalongan, as seen from the viewpoint of the academic community and stakeholders. In this study, documentation, interviews, and observation are the methods used for gathering data. The academic community and stakeholders of K.H. Abdurrahman Wahid State Islamic University Pekalongan's Faculty of Tarbiyah and Keguruan Sciences are the subjects of this study. The study's findings show that organizational growth inextricably linked to the three pillars of higher education is among the top priorities for FTIK UIN KH Abdurrahman Wahid Pekalongan from the viewpoints of stakeholders and the academic community. In education and learning, research, publications, services, and supporting fields, organizational development refers to the development of research, publications, services, education and learning, and related sectors.
Clima organizacional y desempeño docente: un análisis correlacional
Authors: Cedeño Cabrera Diana Emperatriz , Zapata Barros Ángel Enrique , Delgado Mendoza Lianet , Cano de la Cruz Yullio 
Published: July 2024

El propósito del presente artículo fue analizar la influencia del clima organizacional en el desempeño de los docentes en la Unidad Educativa Particular Latino en el periodo 20018-1019. La investigación fue de tipo correlacional – transversal, la cual permitió establecer la influencia entre los dos aspectos indagados en un determinado momento. De una población de 45 docentes se seleccionó una muestra de 36 docentes a los cuales se les aplicó una encuesta como instrumento ad hoc elaborado por los autores para la presente investigación y validado por consulta a especialistas. Para determinar el desempeño docente se utilizó el análisis de los productos de la actividad pedagógica. Los resultados obtenidos mostraron que el clima organizacional en la Unidad Educativa es muy bueno, al correlacionarlo con el desempeño docente mediante la prueba estadística del Chi cuadrado, con dos grados de libertad y una probabilidad de cometer un error tipo I de 0,10 se obtuvo un valor de = 4,61, por lo que se concluye que si existe relación entre el clima organizacional y el desempeño docente.
Pregnancy outcomes in Grand multiparous women: Does parity matter? A comparative study
Authors: Yimer Nigus Bililign , Tenaw Zelalem , Gedefaw Abel 
Published: July 2024

Background: Grand multiparity is still a common condition in developing countries. Although older literature showed the effect of grand multiparity on adverse pregnancy, recent reports fail to show clear evidence on the contribution of grand multiparity to adverse outcomes.
Objective: This study aimed to compare maternal and perinatal outcomes in grand multiparous and low multiparous women in Southern Ethiopia.
Methods: Comparative cross-sectional study design was employed from February to June 2018. Four hundred sixty-one (461) mothers were included in the study. Data were collected using structured interviewer-administered questionnaire and extracting from patient charts. Data were analyzed using STATA version 14. Descriptive and logistic regression analyses were computed. Statistically significant variables were declared at P-value less than 0.05.
Results: Of the study participants, 39% (95% CI: 34.6%-43.5%) and nearly one-fourth (24.9%) (95% CI: 21.1%-29.1%) of them had at least one adverse maternal and perinatal outcome, respectively. Anemia and cesarean delivery were the most frequently encountered maternal outcomes in grand and low multiparous women, respectively. Stillbirth was reported higher in grand multiparas. When adjusted for other socio-demographic and obstetric variables, parity did not show a statistically significant difference in both maternal and perinatal outcomes.
Conclusion and recommendations: Parity did not show a statistically significant difference in both adverse maternal and perinatal outcomes. Many adverse pregnancy outcomes reported higher in grand multiparous women. Comprehensive obstetric care and special attention to grand multiparas may decrease obstetric complications. Further longitudinal researches are needed to better elucidate this finding.
Keywords: Maternal outcome, Perinatal outcome, Parity, Ethiopia.
SCHOOL LEVEL MENSTRUAL HYGIENE MANAGEMENT IN OROMIA REGION OF ETHIOPIA
Authors: Kaba Mirgissa , Adugna Zelalem 
Published: July 2024

Abstract
Background: Menstruation is a biological occurrence for women of reproductive age. Its management and men’s role however is determined by socio-cultural factors. Yet, there is limited evidence on support and guidance girls obtain from boys on menstrual hygiene and management. This study aims to identify school based menstrual hygiene and management interventions and the role of boys in Oromia region, Ethiopia.
Method: The study was carried out in 2017-18 academic year in eight Oromia Development Association supported public schools where sport for life interventions were running. Schoolboys and girls aged 12-15, parents and school teachers participated in the study. Focus Group Discussion (FGDs) with boys and girls and key informant interviews (KII) with parents were completed. Data so collected were transcribed and translated into English and themes were developed following the objective of the study. Interpretation and presentation of the findings were made substantiated with shared opinions directly quoted.
Findings: The study shows that after two years of school based intervention boys in the study schools and parents recognized menstruation as a natural biological occurrence and a blessing rather than a curse. Common arguments by all participants alike show that ‘We learnt that menstruation is a mark of healthy growth of girls. It should be the absence of it that should be the source of concern’. With dedicated room, sanitary napkin and positive recognition from boys and schoolteachers, management of menstrual hygiene became easier. Boys not only stopped teasing girls but also started contributing money to purchase sanitary napkins. Liaising such school level intervention with parents extended support to girls to home.
Conclusion: Although further study with mixed method may help to document level of changes, school level awareness raising on Sexual Reproductive Health and mobilization of resources for management of menstrual hygiene could improve girl’s academic performance.
Key terms: Menstrual hygiene, adolescents, Sexual Reproductive Health, Oromia, Ethiopia
Traditional Ethiopian Coffee Ceremony in a Rural Ethiopian Hospital to Increase Hospital-Based Delivery Rates: A Randomized Controlled Trial
Authors: Limperg Tobias , Verregghen Maarten , De Ridder Iris , Allsworth Jenifer , Anderson Ted 
Published: July 2024

AbstractWord count: 250

Background
Ethiopia has an estimated maternal mortality ratio of 353 per 100,000 live births. In an effort to improve acceptability of hospital-based deliveries, health facilities have adopted traditional practices in the labor ward. We hypothesized that offering postpartum coffee ceremonies to antenatal care patients would increase the hospital-based delivery rate.

Trial design
Non-blinded randomized controlled trial

Methods
From April to June 2015, pregnant patients presenting for their first antenatal care visit were block-randomized per day to receive a postpartum coffee ceremony, compared to not receiving coffee postpartum. The primary outcome was presentation for delivery at Gambo Hospital.

Results
254 Patients were randomized to the ceremony group and 185 to the no-ceremony group. There was no significant difference in hospital-based delivery rates between the randomized groups (32.1% versus 31.7%; relative risk 1.01; 95% CI, 0.76 to 1.35). Results were likely compromised by patients’ misunderstanding of the randomization process. 12.7% of patients self-reported that the postpartum coffee ceremony served as motivation to deliver in the hospital. Hospital delivery was positively associated with shorter travel time, higher education grade, and previous delivery at a health-facility. It was negatively associated with previous home delivery and a higher number of antenatal care visits.

Conclusions
The likely flawed randomization process undercuts our ability to draw conclusions about the effect of this sociocultural intervention on the observed hospital-based delivery increase. This study exemplifies the difficulty of applying conventional research concepts to sociocultural interventions, especially in a setting of low educational levels, language barriers, and limited research capacity.