bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydroxyapatite Hierarchically Nanostructured Porous Hollow Microspheres: Rapid, Sustainable Microwave‐Hydrothermal Synthesis by Using Creatine Phosphate as an Organic Phosphorus Source and Application in Drug Delivery and Protein Adsorption
Authors: Qi Chao , Zhu Ying‐Jie , Lu Bing‐Qiang , Zhao Xin‐Yu , Zhao Jing , Chen Feng , Wu Jin 
Published: March 2013

AbstractHierarchically nanostructured porous hollow microspheres of hydroxyapatite (HAP) are a promising biomaterial, owing to their excellent biocompatibility and porous hollow structure. Traditionally, synthetic hydroxyapatite is prepared by using an inorganic phosphorus source. Herein, we report a new strategy for the rapid, sustainable synthesis of HAP hierarchically nanostructured porous hollow microspheres by using creatine phosphate disodium salt as an organic phosphorus source in aqueous solution through a microwave‐assisted hydrothermal method. The as‐obtained products are characterized by powder X‐ray diffraction (XRD), Fourier‐transform IR (FTIR) spectroscopy, SEM, TEM, Brunauer–Emmett–Teller (BET) nitrogen sorptometry, dynamic light scattering (DLS), and thermogravimetric analysis (TGA). SEM and TEM micrographs show that HAP hierarchically nanostructured porous hollow microspheres consist of HAP nanosheets or nanorods as the building blocks and DLS measurements show that the diameters of HAP hollow microspheres are within the range 0.8–1.5 μm. The specific surface area and average pore size of the HAP porous hollow microspheres are 87.3 m2g−1 and 20.6 nm, respectively. The important role of creatine phosphate disodium salt and the influence of the experimental conditions on the products were systematically investigated. This method is facile, rapid, surfactant‐free and environmentally friendly. The as‐prepared HAP porous hollow microspheres show a relatively high drug‐loading capacity and protein‐adsorption ability, as well as sustained drug and protein release, by using ibuprofen as a model drug and hemoglobin (Hb) as a model protein, respectively. These experiments indicate that the as‐prepared HAP porous hollow microspheres are promising for applications in biomedical fields, such as drug delivery and protein adsorption.
Controlled Synthesis of Thorium and Uranium Oxide Nanocrystals
Authors: Hudry Damien , Apostolidis Christos , Walter Olaf , Gouder Thomas , Courtois Eglantine , Kübel Christian , Meyer Daniel 
Published: March 2013

AbstractVery little is known about the size and shape effects on the properties of actinide compounds. As a consequence, the controlled synthesis of well‐defined actinide‐based nanocrystals constitutes a fundamental step before studying their corresponding properties. In this paper, we report on the non‐aqueous surfactant‐assisted synthesis of thorium and uranium oxide nanocrystals. The final characteristics of thorium and uranium oxide nanocrystals can be easily tuned by controlling a few experimental parameters such as the nature of the actinide precursor and the composition of the organic system (e.g., the chemical nature of the surfactants and their relative concentrations). Additionally, the influence of these parameters on the outcome of the synthesis is highly dependent on the nature of the actinide element (thorium versus uranium). By using optimised experimental conditions, monodisperse isotropic uranium oxide nanocrystals with different sizes (4.5 and 10.7 nm) as well as branched nanocrystals (overall size ca. 5 nm), nanodots (ca. 4 nm) and nanorods (with ultra‐small diameters of 1 nm) of thorium oxide were synthesised.
Tuning the Surface Structure of Nitrogen‐Doped TiO2 Nanofibres—An Effective Method to Enhance Photocatalytic Activities of Visible‐Light‐Driven Green Synthesis and Degradation
Authors: Zheng Zhanfeng , Zhao Jian , Yuan Yong , Liu Hongwei , Yang Dongjiang , Sarina Sarina , Zhang Hongjie , Waclawika Eric R. , Zhu Huaiyong 
Published: March 2013

AbstractNitrogen‐doped TiO2 nanofibres of anatase and TiO2(B) phases were synthesised by a reaction between titanate nanofibres of a layered structure and gaseous NH3 at 400–700 °C, following a different mechanism than that for the direct nitrogen doping from TiO2. The surface of the N‐doped TiO2 nanofibres can be tuned by facial calcination in air to remove the surface‐bonded N species, whereas the core remains N doped. N‐Doped TiO2 nanofibres, only after calcination in air, became effective photocatalysts for the decomposition of sulforhodamine B under visible‐light irradiation. The surface‐oxidised surface layer was proven to be very effective for organic molecule adsorption, and the activation of oxygen molecules, whereas the remaining N‐doped interior of the fibres strongly absorbed visible light, resulting in the generation of electrons and holes. The N‐doped nanofibres were also used as supports of gold nanoparticle (Au NP) photocatalysts for visible‐light‐driven hydroamination of phenylacetylene with aniline. Phenylacetylene was activated on the N‐doped surface of the nanofibres and aniline on the Au NPs. The Au NPs adsorbed on N‐doped TiO2(B) nanofibres exhibited much better conversion (80 % of phenylacetylene) than when adsorbed on undoped fibres (46 %) at 40 °C and 95 % of the product is the desired imine. The surface N species can prevent the adsorption of O2 that is unfavourable for the hydroamination reaction, and thus, improve the photocatalytic activity. Removal of the surface N species resulted in a sharp decrease of the photocatalytic activity. These photocatalysts are feasible for practical applications, because they can be easily dispersed into solution and separated from a liquid by filtration, sedimentation or centrifugation due to their fibril morphology.
ChemInform Abstract: Stabilized Gold Clusters by Heterostructured Transition‐Metal Oxide—Mesoporous Silica Supports for Enhanced Catalytic Activities for CO Oxidation.
Authors: Ma Guicen , Binder Andrew , Chi Miaofang , Liu Chao , Jin Rongchao , Jiang De‐en , Fan Jie , Dai Sheng 
Published: March 2013

AbstractGold clusters, Au25 and Au144, after removal of their protecting thiolate ligands by thermal treatment are stabilized by heterostructured mesoporous CuO—mSiO2 and Co3O4—mSiO2 supports.
ChemInform Abstract: Kinetic Resolution of Propargylamines via a Highly Enantioselective Non‐enzymatic N‐Acylation Process.
Authors: Kolleth Amandine , Christoph Sarah , Arseniyadis Stellios , Cossy Janine 
Published: March 2013

AbstractA variety of acetamides (III) is obtained by a highly enantioselective acetyl transfer from acylating agent (II) to amines (I).
ChemInform Abstract: One‐Point Binding Ligands for Asymmetric Gold Catalysis: Phosphoramidites with a TADDOL‐Related but Acyclic Backbone.
Authors: Teller Henrik , Corbert Matthieu , Mantilli Luca , Gopakumar Gopinadhanpillai , Goddard Richard , Thiel Walter , Fuerstner Alois 
Published: March 2013

AbstractLigands of type (I) and (II) are developed as excellent components for gold catalysis.
ChemInform Abstract: Pd‐Catalyzed Borylative Cyclization of 1,7‐Enynes.
Authors: Pardo‐Rodriguez Virtudes , Bunuel Elena , Collado‐Sanz Daniel , Cardenas Diego J. 
Published: March 2013

AbstractThe cyclization of enynes (I) with dipinacolyl hypodiborate (II) leads to desired cyclic boronate derivatives (III), which can be oxidized to alcohols, e.g. compound (IV).
ChemInform Abstract: Unconventional Titania Photocatalysis: Direct Deployment of Carboxylic Acids in Alkylations and Annulations.
Authors: Manley David W. , McBurney Roy T. , Miller Philip , Howe Russell F. , Rhydderch Shona , Walton John C. 
Published: March 2013

AbstractPhotodimerization of carboxylic acids and alkylations of alkenes with carboxylic acids are promoted by TiO2 or platinized TiO2.
ChemInform Abstract: Asymmetric Direct α‐Hydroxylation of β‐Oxo Esters Catalyzed by Chiral Quaternary Ammonium Salts Derived from Cinchona Alkaloids.
Authors: Yao Hongjie , Lian Mingming , Li Zhi , Wang Yakun , Meng Qingwei 
Published: March 2013

AbstractThe ammonium salt (I) efficiently promotes the enantioselective α‐hydroxylation of indanone‐ and tetralone‐derived β‐oxo esters under mild conditions.
ChemInform Abstract: Characterization of Novel Cs and K Substituted Phosphotungstic Acid Modified MCM‐41 Catalyst and Its Catalytic Activity Towards Acetylation of Aromatic Alcohols.
Authors: Rana Surjyakanta , Mallick Sujata , Rath Dharitri , Parida K. M. 
Published: March 2013

AbstractThe catalysts exhibit excellent activity for the acetylation of phenols and benzyl alcohols.
ChemInform Abstract: Development of an Intramolecular Aryne Ene Reaction and Application to the Formal Synthesis of (.+‐.)‐Crinine.
Authors: Candito David A. , Dobrovolsky Dennis , Lautens Mark 
Published: March 2013

AbstractThe scope of the LDA‐promoted process is studied in detail with a variety of structurally diverse aryne precursors.
ChemInform Abstract: Scope and Mechanistic Analysis of the Enantioselective Synthesis of Allenes by Rhodium‐Catalyzed Tandem Ylide Formation/[2,3]‐Sigmatropic Rearrangement Between Donor/Acceptor Carbenoids and Propargylic Alcohols.
Authors: Li Zhanjie , Boyarskikh Vyacheslav , Hansen Joern H. , Autschbach Jochen , Musaev Djamaladdin G. , Davies Huw L. 
Published: March 2013

AbstractReaction of carbenoids with propargylic alcohols results in tandem oxonium ylide formation/[2,3]‐sigmatropic rearrangement to yield allenes with high enantioselectivity.
ChemInform Abstract: Amination of Aryl Halides by Using an Environmentally Benign, Recyclable Copper Catalyst.
Authors: Huang Manna , Wang Leilei , Zhu Xinhai , Mao Zuxing , Kuang Daizhi , Wan Yiqian 
Published: March 2013

AbstractA novel and environmentally benign homogeneous catalyst system is developed and used for the direct amination of aryl halides with ammonia consisting of naturally occurring sucrose and CuSO4 in an aqueous solution of PEG‐200.
ChemInform Abstract: Readily Available (S)‐Proline‐Derived Organocatalysts for the Lewis Acid‐Mediated Lewis Base‐Catalyzed Stereoselective Aldol Reactions of Activated Thioesters.
Authors: Bonsignore Martina , Benaglia Maurizio , Cozzi Franco , Genoni Andrea , Rossi Sergio , Raimondi Laura 
Published: March 2013

AbstractThe bisphosphine oxide catalyst PPO is optimal as catalyst in aldol reactions of thioesters (I) with aromatic aldehydes.
ChemInform Abstract: Palladium‐Catalyzed Alkyne Insertion/Suzuki Reaction of Alkyl Iodides.
Authors: Monks Brendan M. , Cook Silas P. 
Published: March 2013

AbstractSelective migratory insertion of alkynes avoids β‐hydride elimination and allows the access to regio‐ and stereodefined unsymmetrical, tetrasubstituted olefin units which bear an alicyclic ring system.
ChemInform Abstract: Phosphine‐Catalyzed Rauhut—Carrier Domino Reaction: A Facile Strategy for the Construction of Highly Functionalized Cyclopentene.
Authors: Hu Chongchong , Geng Zhishuai , Ma Jianze , Huang You , Chen Ruyu 
Published: March 2013

AbstractA convenient and efficient method for the synthesis of highly functionalized cyclopentene skeletons with high chemo‐ and diastereoselectivities is reported.
ChemInform Abstract: Access to 2,3‐Disubstituted Benzofurans Through One‐Pot Acid‐Catalyzed Nucleophilic Substitution/TBAF‐Mediated Oxacycloisomerization.
Authors: Reddy Chada Raji , Krishna Gaddam , Kavitha Nerella , Latha Bellamkonda , Shin Dong‐Soo 
Published: March 2013

AbstractA mild, efficient and metal‐free synthesis of benzofurans.
ChemInform Abstract: β‐Lactam‐Synthon‐Interceded Diastereoselective Synthesis of Functionally Enriched Thioxo‐imidazolidines, Imidazolidin‐2‐ones, Piperazine‐5,6‐diones and 4,5‐Dihydroimidazoles.
Authors: Mehra Vishu , Singh Pardeep , Kumar Vipan 
Published: March 2013

AbstractStarting from β‐lactam azides (I) or analogous amino derivatives (VI), convenient protocols are developed for the synthesis of the title compounds via (diastereomeric) aminocarboxylic acid esters.
ChemInform Abstract: Preparation and Rearrangement of N‐Vinyl Nitrones: Synthesis of Spiroisoxazolines and Fluorene‐Tethered Isoxazoles.
Authors: Mo Dong‐Liang , Wink Donald A. , Anderson Laura L. 
Published: March 2013

AbstractThe thermal rearrangement of fluorenone N‐vinyl nitrones (IIIc)‐(IIIf) gives rise to spiroisoxazolines such as (VIII) and (IX).
ChemInform Abstract: Recyclable Clay‐Supported Cu(II)‐Catalyzed Tandem One‐Pot Synthesis of 1‐Aryl‐1,2,3‐triazoles.
Authors: Mohammed Shabber , Padala Anil K. , Dar Bashir A. , Singh Baldev , Sreedhar B. , Vishwakarma Ram A. , Bharate Sandip B. 
Published: March 2013

AbstractCuO nanoparticles, supported on montmorillonite K10, are found to catalyze the azidation of arylboronic acids as well as the 1,3‐dipolar cycloaddition of the resulting organic azides to terminal alkynes.
ChemInform Abstract: Regioselective Synthesis of 2‐(2‐Hydroxyaryl)pyridines from the Reactions of Benzynes with Pyridine N‐Oxides.
Authors: Shaibu Balagopal S. , Kawade Rahul Kisan , Liu Rai‐Shung 
Published: March 2013

AbstractThe title reaction affords the desired products of type (III), (VIII) and (X) with complete regioselectivity.
ChemInform Abstract: A New Flow Methodology for the Expedient Synthesis of Drug‐Like 3‐Aminoindolizines.
Authors: Lange Paul P. , Bogdan Andrew R. , James Keith 
Published: March 2013

AbstractThe present flow‐based synthesis of diversely functionalized indolizines and their aza‐analogues is achieved via a tandem Sonogashira— cycloisomerization sequence.
ChemInform Abstract: Ring‐Closing Metathesis/Isomerization/Pictet—Spengler Cascade via Ruthenium/Chiral Phosphoric Acid Sequential Catalysis.
Authors: Cai Quan , Liang Xiao‐Wei , Wang Shou‐Guo , Zhang Jun‐Wei , Zhang Xiao , You Shu‐Li 
Published: March 2013

AbstractThe method affords various optically active tetrahydro‐β‐carboline derivatives, which are of interest as heterocyclic scaffolds for natural products and pharmaceuticals.
ChemInform Abstract: Rh‐Catalyzed Borylation of N‐Adjacent C(sp3)—H Bonds with a Silica‐Supported Triarylphosphine Ligand.
Authors: Kawamorita Soichiro , Miyazaki Tatsuya , Iwai Tomohiro , Ohmiya Hirohisa , Sawamura Masaya 
Published: March 2013

AbstractDirect borylation of amides, ureas, and 2‐aminopyridine derivatives at the position adjacent to the N‐atom results in formation of α‐aminoalkylboronates.
ChemInform Abstract: Copper(I)‐Catalyzed Formal Carboboration of Alkynes: Synthesis of Tri‐ and Tetrasubstituted Vinylboronates.
Authors: Alfaro Ricardo , Parra Alejandro , Aleman Jose , Garcia Ruano Jose Luis , Tortosa Mariola 
Published: March 2013

AbstractTerminal and internal alkynes as well as 1,3‐enynes can be used with success as substrates.
ChemInform Abstract: The Synthesis and Biological Activities of 3‐Acyl‐2,3‐dihydro‐1,3,4‐oxadiazole/3‐Acyl‐1,3,4‐oxadiazoline Derivatives Obtained from Hydrazide‐hydrazones
Authors: Rollas Sevim , Karakus Sevgi 
Published: March 2013

AbstractReview: 98 refs.
Modeling, Simulation and Experimental Verification of the Break‐Up of Liquid Jets and the Drop Formation in the Centrifugal Field
Authors: Gramlich Simon , Piesche Manfred 
Published: March 2013

AbstractVorgestellt wird ein physikalisch‐mathematisches Modell zur Beschreibung des Zerfalls von Flüssigkeitsstrahlen und der Tropfenbildung im Zentrifugalfeld unter Berücksichtigung der umgebenden Gasphase und der Viskosität. Das Modell beruht auf der Methode der kleinen Schwingungen, bei der die Strömung in eine zeitlich gemittelte Grundströmung und eine instationäre Störungsbewegung unterteilt wird. Die resultierenden Tropfengrößen werden mit experimentellen Daten verglichen und zeigen eine gute Übereinstimmung. Als Randbedingung dient dem Modell die experimentell ermittelte Zerfallslänge.
Hydrodynamics and Mass Transfer in a Pellet String Reactor for Gas‐Liquid‐Solid Reactions
Authors: Langsch Robert , Haase Stefan , Lange Rüdiger 
Published: March 2013

AbstractIn dieser Arbeit wurden die Hydrodynamik einer Gas/Flüssig‐Zweiphasenströmung und erzielbare Stofftransportraten in einem Perlschnurreaktor charakterisiert. Die Katalysatorpackung im Reaktor besteht aus runden Kanälen mit einem Kanaldurchmesser von 1,41 mm, in die kugelförmige Katalysatorpartikel mit einem Durchmesser von 0,8 mm integriert sind. Bei gleichzeitig ablaufender Reaktion (Flüssigphasenhydrierung von α‐Methylstyrol) konnten volumetrische Gesamtstoffdurchgangskoeffizienten für Wasserstoff zwischen 0,8 und 5,5 s–1 ermittelt werden. Aufgrund der hohen erzielbaren Stofftransportraten und des einfachen Aufbaus können Perlschnurreaktoren schnell in der Industrie implementiert werden und tragen zur Generierung hocheffizienter Reaktionsapparate bei.
Improving the Methanation Process
Authors: Krier Claudia , Hackel Marius , Hägele Christian , Urtel Heiko , Querner Claudia , Haas Andreas 
Published: March 2013

AbstractThe production of substitute natural gas based on coal or biomass is once again back in focus, initiated by rising natural gas prices and the desire to become independent from natural gas imports. It is necessary to optimize the commercial process, e.g., by using harsher process conditions to reduce the recycle ratio. In line with this the development of new catalytic materials as well as the understanding of the reaction kinetics to control the heat of reaction and predict the lifetime of the catalyst is required.
Life Cycle Cost Analysis for Decision Support in Chemical Process Development
Authors: Sell Ina , Ott Denise , Kralisch Dana 
Published: March 2013

AbstractDie Notwendigkeit umweltfreundlicher Prozesse als entscheidendes Merkmal der Wettbewerbsfähigkeit steht zunehmend im Fokus der chemischen Industrie. Grundlage für Entscheidungsprozesse bei der Entwicklung derartiger Prozesse können Ökobilanzanalysen bieten. Neue Technologien werden sich jedoch nur dann etablieren können, wenn sie auch zu kosteneffizienten Produktionsprozessen führen. Lebenszykluskostenanalysen bieten eine geeignete methodische Grundlage, die kostenseitige Bewertung alternativer Optionen der Prozessentwicklung mit ökologischen Entscheidungskriterien zu koppeln, wobei die Ergebnisse beider Methoden in einem Öko‐Portfolio verknüpft werden können. Die Entwicklung sowohl ökologisch als auch ökonomisch effizienter Prozesse kann somit bereits in der frühen Designphase der chemischen Prozessentwicklung gezielt unterstützt und gesteuert werden.
One‐Pot Conversion of Sugar and Sugar Polyols to n‐Alkanes without CC Dissociation over the Ir‐ReOx/SiO2 Catalyst Combined with H‐ZSM‐5
Authors: Chen Kaiyou , Tamura Masazumi , Yuan Zhenle , Nakagawa Yoshinao , Tomishige Keiichi 
Published: March 2013

AbstractHigh (≥95 % C) yields of n‐hexane and n‐pentane were obtained by hydrogenolysis of aqueous sorbitol and xylitol, respectively, at 413–443 K by using the Ir‐ReOx/SiO2 catalyst combined with H‐ZSM‐5 as a cocatalyst and n‐dodecane as a cosolvent. The direct production of n‐hexane from glucose or cellobiose can be achieved by using the same system. The catalyst can be reused simply by the removal of the n‐dodecane phase, which contains the product alkane, and the addition of fresh n‐dodecane and substrate.
A novel fluorescent sensor for measurement of CFTR function by flow cytometry
Authors: Vijftigschild Lodewijk A. W. , van der Ent Cornelis K. , Beekman Jeffrey M. 
Published: March 2013

AbstractMutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause cystic fibrosis. CFTR‐dependent iodide transport measured by fluorescent quenching of ectopically expressed halide‐sensitive yellow fluorescent protein (YFP) is widely being used to study CFTR function by microscopy or plate readers. Since YFP fluorescence in these systems is dependent on YFP expression levels and iodide concentration, differences in sensor expression level between experimental units are normalized at the start of each experiment. To allow accurate measurement of CFTR function by flow cytometry, we reasoned that co‐expression of an iodide insensitive fluorescent protein would allow for normalization of sensor expression levels and more accurate quantification of CFTR function. Our data indicated that dsRed and mKate fluorescence are iodide insensitive, and we determined an optimal format for co‐expression of these fluorescent proteins with halide‐sensitive YFP. We showed using microscopy that ratiometric measurement (YFP/mKate) corrects for differences in sensor expression levels. Ratiometric measurements were essential to accurately measure CFTR function by flow cytometry that we here describe for the first time. Mixing of wild type or mutant CFTR expressing cells indicated that addition of approximately 10% of wild type CFTR expressing cells could be distinguished by ratiometric YFP quenching. Flow cytometric ratiometric YFP quenching also allowed us to study CFTR mutants associated with differential residual function upon ectopic expression. Compared with conventional plate‐bound CFTR function assays, the flow cytometric approach described here can be used to study CFTR function in suspension cells. It may be further adapted to study CFTR function in heterologous cell populations using cell surface markers and selection of cells that display high CFTR function by cell sorting. © 2013 International Society for Advancement of Cytometry
Sex and litter effects on anxiety and DNA methylation levels of stress and neurotrophin genes in adolescent rats
Authors: Kosten Therese A. , Huang Wen , Nielsen David A. 
Published: March 2013

AbstractMaternal care variations associate with DNA methylation of the glucocorticoid receptor gene, Nr3c1, in hippocampus at a nerve‐growth factor‐inducible protein 1 binding site. Epigenetic regulation of brain‐derived neurotrophin factor is affected by early stress. These systems contribute to anxiety and fear. Early stress has sex‐dependent effects perhaps reflecting sex differences in maternal care. Altering litter gender composition affects maternal behavior and DNA methylation levels of another gene in hippocampus and nucleus accumbens (NAc). We now test if DNA methylation levels of Nr3c1, Egr1, and Bdnf differ by litter composition or sex. Rats from mixed‐ or single‐sex litters were tested for anxiety and fear on postnatal day 35. Brain tissues were collected and analyzed using direct sequencing methods. Females showed hypermethylation of Nr3c1 of hippocampal DNA and litter composition modified sex effects on methylation of Egr1 in NAc. Few differences were seen for Bdnf. LGC modified some sex differences in behavior. © 2013 Wiley Periodicals, Inc. © 2013 Wiley Periodicals, Inc. Dev Psychobiol 56: 392–406, 2014.