bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of an Association Rule Mining-Based Method to Infer Associations Between Medications and Problems
Authors: McCoy A. , Henkin S. , Flaherty M. , Sittig D. , Wright A. 
Published: March 2013

SummaryBackground: In a prior study, we developed methods for automatically identifying associations between medications and problems using association rule mining on a large clinical data warehouse and validated these methods at a single site which used a self-developed electronic health record. Objective: To demonstrate the generalizability of these methods by validating them at an external site.Methods: We received data on medications and problems for 263,597 patients from the University of Texas Health Science Center at Houston Faculty Practice, an ambulatory practice that uses the Allscripts Enterprise commercial electronic health record product. We then conducted association rule mining to identify associated pairs of medications and problems and characterized these associations with five measures of interestingness: support, confidence, chi-square, interest and conviction and compared the top-ranked pairs to a gold standard.Results: 25,088 medication-problem pairs were identified that exceeded our confidence and support thresholds. An analysis of the top 500 pairs according to each measure of interestingness showed a high degree of accuracy for highly-ranked pairs.Conclusion: The same technique was successfully employed at the University of Texas and accuracy was comparable to our previous results. Top associations included many medications that are highly specific for a particular problem as well as a large number of common, accurate medication-problem pairs that reflect practice patterns.Citation: Wright A, McCoy A, Henkin S, Flaherty M, Sittig D. Validation of an association rule mining-based method to infer associations between medications and problems. ppl Clin Inf 2013; 4: 100–109http://dx.doi.org/10.4338/ACI-2012-12-RA-0051
Erchempert, a Reluctant Fustigator of His People: History and Ethnic Pride in Southern Italy at the End of the Ninth Century
Authors: Berto Luigi Andrea 
Published: March 2013

ABSTRACT
At the end of the ninth century, the Cassinese monk Erchempert composed a chronicle (ca. 774–889) blaming the southern Italian Lombard leaders for recent Lombard defeats. Erchempert hoped that future generations might learn from their forebears' folly. This article analyzes the reasons why, in the wake of his monastery's destruction by Muslim raiders, Erchempert did not express a generalized criticism toward all the elites of his homeland. The article also demonstrates that Erchempert's attachment to his people and his pride in being Lombard sometimes led him to stray from his intended narrative of Lombard failures and catastrophes.
Ethnic Identification, Food, and Depression: Louise DeSalvo's Memoirs and the Female Italian American Experience
Authors: Patrona Theodora 
Published: March 2013

ABSTRACT
This article discusses Louise DeSalvo's memoirs, Vertigo and Crazy in the Kitchen, examining DeSalvo's self-definition through ethnic cuisine. Specifically, this article explores the interrelationships among ethnic identification, culinary practice, and female self-representation within the context of DeSalvo's turbulent Italian American family. By shedding light on her painful experiences, DeSalvo projects a powerful ethnic female figure, one who is ultimately strengthened by the difficulties and challenges she has endured.
Children, education and migration: Win-win policy responses for codevelopment
Authors: Cortina Jeronimo 
Published: March 2013

AbstractAmong the many challenges that the world faces today, one is of particular relevance to
international migration and development. The world faces significant demographic changes
affecting the future developmental prospects of both developed and less developed countries.
More developed countries are simultaneously facing low fertility rates and ageing populations,
while less developed countries, in contrast, are experiencing higher birth rates and a significant
“youth bulge.”The fiscal, social, economic and political implications of these imbalances are obvious for
both developed and less developed countries, while the policy interventions to attenuate these
impacts, however, are not so obvious. More developed countries, for instance could increase
productivity levels, significantly increase the age of retirement and eligibility for benefits and
could potentially use other tax revenues to fund benefits. For less developed countries the policy
choices are basically reduced to interventions seeking to increase the rate of economic growth
in order to incorporate younger generations into the labour market and to expand the state’s
capacities to provide basic social services such as health and education.
One of the single most accommodative policies that could potentially address these
challenges is international migration. On average, migrants tend to be young people seeking
for the most part better economic prospects to support their families. Migrants moving from
countries with high unemployment rates, and dire prospects to better their lives, to countries
with an increasing ageing population and low fertility rates could not only balance out these
demographic imbalances but also improve the developmental prospects of both developed and
less developed countries.
Strengthening respect for family life and family unity in migration policy-making
Authors: Bingham John K. 
Published: March 2013

AbstractCivil society, international organizations and governments have invested much in looking at
issues of feminization of migration (i.e., women migrants), child migrants, migrant workers, etc.
While absolutely proper subjects for urgent attention and change, too much of the discussion
of immigration has become atomized, neglecting the further reality that these men, women and
children are also members of families split across borders. International migration separates
untold millions of families—for years, for decades, some forever.
Pragmatic Aesthetics and the Autistic Artist
Authors: Hunter Kyle , Barnbaum Deborah 
Published: March 2013

AbstractThere are many prominent examples of artists with autism. However, even when confronted with evidence of these accomplished autistic savants, pragmatic aesthetic theories cannot adequately account for the work of these accomplished artists as artists. This article first examines the nature of autism and explores a prominent psychological theory that purports to explain autistic symptoms. This prominent theory, the theory of mind thesis, holds that autistic symptoms are the result of the failure of persons with autism to make certain types of secondorder propositional attitude attributions. Second, the article describes the work of three visual artists with autism. There can be no doubt that these individuals are in fact artists. Third, the article examines pragmatic aesthetic theory and demonstrates why the pragmatic theory fails to adequately account for the accomplishment of autistic artists. The unique psychological deficits that characterize autism present a challenge to pragmatic aesthetic theories in particular. The conclusion is that the pragmatic theory’s inability to accommodate the artist autistic artist is a profound shortcoming. A revision of the pragmatic theory is called for, as is embracing of the development of the special talents of persons with autism.
The Five‐Factor Model of Impulsivity‐Like Traits and Emotional Lability in Aggressive Behavior
Authors: Dvorak Robert D. , Pearson Matthew R. , Kuvaas Nicholas J. 
Published: March 2013

AbstractFactors that increase automatic psychological processes may result in impulsive action and, consequently, aggressive behavior. The current cross‐sectional study examined the association between the five‐factor model of impulsivity‐like traits (negative urgency, positive urgency, premeditation, perseverance, and sensation seeking), emotional lability, and physically aggressive behaviors among college students (n = 481) in a negative binomial hurdle model. In the logistic portion of the model, emotional lability was related to a higher likelihood of engaging in aggressive acts in the past 6 months. The association between emotional lability and the likelihood of aggressive behavior was moderated by two impulsivity‐like traits: negative urgency and positive urgency. Specifically, emotional lability was related to engaging in aggressive acts among those with high negative urgency, and among those with low positive urgency. In the count portion of the model, emotional lability was uniquely related to the number of aggressive acts in the past 6 months. Our results indicate that emotional lability and facets of impulsivity interactively relate to engagement in aggressive behavior, suggesting that these variables be integrated into models of aggression. Aggr. Behav. 39 :222‐228, 2013. © 2013 Wiley Periodicals, Inc.
Anthelminthic activity of the cyclotides (kalata B1 and B2) against schistosome parasites
Authors: Malagón David , Botterill Bonnie , Gray Darren J. , Lovas Erica , Duke Mary , Gray Christian , Kopp Steven R. , Knott Lyn M. , McManus Donald P. , Daly Norelle L. , Mulvenna Jason , Craik David J. , Jones Malcolm K. 
Published: March 2013

ABSTRACTThe risk of reduced sensitivity of the human schistosomes to praziquantel has led to efforts to find new therapies. Here, the cyclotides kalata B1 (kB1), kalata B2 (kB2), MCoCC‐1, and MCoTI‐II, cyclic peptides extracted from plants and shown to be potent against nematodes and insects, were tested for antischistosome activity. In vitro assays showed that high concentrations (500–1000 μg/mL) of either kB1 or kB2 killed Schistosoma japonicum and Schistosoma mansoni adults within 5 min, whereas MCoTI‐II and MCoCC‐1 had no effect. Lethal concentrations to kill 50% of the population for kB2 was 15.5 ± 7.4 μg/mL at 1 h for male S. japonicum (Philippine strain). Males were more susceptible than females. kB2 showed higher antischistosome activity than kB1 and killing time was concentration‐dependent. Mode of action studies revealed that kB1 and 2 lysed the tegument of adult worms. Lysis of myofibrils was not demonstrated, but longitudinal and radial muscle fibers were distorted, an observation consistent with strong coiling of the parasites after drug exposure. A single dose of kB2 administered either orally or intravenously, reduced worm burdens in S. japonicum‐infected mice from 15% to 60%. However, treatment of S. mansoni‐infected mice did not result in reduction in worm burdens. Our studies show that kB2 acts as a promising antischistosomal against Philippine S. japonicum, and it or other cyclotides may be developed further as general anthelminthics. With thousands of cyclotides predicted to occur in plants, and the amenability of these peptides to combinatorial variation, there is potential for their exploitation as wide‐spectrum anthelminthics. © 2013 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 100: 461–470, 2013.
X‐Ray Imaging of SAPO‐34 Molecular Sieves at the Nanoscale: Influence of Steaming on the Methanol‐to‐Hydrocarbons Reaction
Authors: Aramburo Luis R. , Ruiz‐Martínez Javier , Sommer Linn , Arstad Bjørnar , Buitrago‐Sierra Robison , Sepúlveda‐Escribano Antonio , Zandbergen Henny W. , Olsbye Unni , de Groot Frank M. F. , Weckhuysen Bert M. 
Published: March 2013

AbstractThe effect of a severe steaming treatment on the physicochemical properties and catalytic performance of H‐SAPO‐34 molecular sieves during the methanol‐to‐hydrocarbons (MTH) reaction has been investigated with a combination of scanning transmission X‐ray microscopy (STXM), catalytic testing, and bulk characterization techniques, including ammonia temperature programmed desorption and 27Al and 29Si magic angle spinning nuclear magnetic resonance. For this purpose, two samples, namely a calcined and a steamed H‐SAPO‐34 catalyst powder, have been compared. It has been found that calcined H‐SAPO‐34 displays a high selectivity towards light olefins, yet shows a poor stability as compared to a zeolite H‐ZSM‐5 catalyst. Moreover, in situ STXM at the carbon K‐edge during the MTH reaction allows construction of nanoscale chemical maps of the hydrocarbon species formed within the H‐SAPO‐34 aggregates as a function of reaction time and steam post‐treatment. It was found that there is an initial preferential formation of coke precursor species within the core of the H‐SAPO‐34 aggregates. For longer times on stream the formation of the coke precursor species is extended to the outer regions, progressively filling the entire H‐SAPO‐34 catalyst particle. In contrast, the hydrothermally treated H‐SAPO‐34 showed similar reaction selectivity, but decreased activity and catalyst stability with respect to its calcined counterpart. These variations in MTH performance are related to a faster and more homogeneous formation of coke precursor species filling up the entire steamed H‐SAPO‐34 catalyst particle. Finally, the chemical imaging capabilities of the STXM method at the Al and Si K‐edge are illustrated by visualizing the silicon islands at the nanoscale before and after steaming H‐SAPO‐34.
Design and Application of a Hybrid Material Featuring Well‐Defined, Tuneable Grafting Sites for Supported Catalysis.
Authors: Popoff Nicolas , Espinas Jeff , Pelletier Jérémie , Szeto Kai C. , Thivolle‐Cazat Jean , Delevoye Laurent , Gauvin Régis M. , Taoufik Mostafa 
Published: March 2013

AbstractA new material based on amorphous silica, and featuring a well‐defined phenolic functionality was prepared in two simple steps by using commercially available, cheap reagents. Silica was first reacted with aluminum isobutyl etherate to yield an aluminum isobutyl site [(≡SiO)2Al(iBu)(Et2O)], which then selectively reacted with a hydroquinone spacer to yield [(≡SiO)2(AlOC6X4OH)(Et2O)] (X=H or F). This support material was then used to tether the organometallic tungstenocarbyne complex [W(≡CtBu)(CH2tBu)3] to yield the surface species [(≡SiO)2(AlOC6X4O‐W(≡CtBu)(CH2tBu)2(Et2O)] (X=H or F). Both H‐ and F‐containing species were fully characterized, and their activities in the self‐metathesis reaction of propene to ethylene and 2‐butenes were found to be two and three times higher, respectively, than the activity of the corresponding tungstenocarbyne complex directly grafted onto silica.
CFD‐assisted Characterization and Optimization of the Structured Mass Transfer Packing QVF DURAPACK®
Authors: Dreiser C. , Gneist G. , Bart H.‐J. 
Published: March 2013

AbstractThe glass packing QVF DURAPACK® was developed to use the advantages of structured mass transfer packings, especially when handling corrosive media. To match up with the latest developments for sheet metal packings, further optimization for liquid‐liquid separation processes was performed for the QVF DURAPACK®. The complex geometry of structured packings and the wall thickness of glass sheets complicate the numerical investigations. The modeling strategy is presented, and the limitations of CFD tools are given. The experimental and numerical results show similar trends as known for perforated metal structures. The extraction efficiency of the packing prototype could also be reproduced with the column design tool LLECMOD.
Two Distinct Thermal Stabilities of DNA and Enzymatic Activities of DNase I in a Multistep Assembly with Carbazole Ligands: Different Binding Characteristics for Duplex and Quadruplex DNA
Authors: Inukai Norie , Kawai Tsuyoshi , Yuasa Junpei 
Published: March 2013

AbstractA partially hydrophobic carbazole ligand ((Im+)2Cz: 2,2′‐(9‐ethyl‐9 H‐carbazole‐3,6‐diyl)bis(ethyne‐2,1‐diyl)bis(1,3‐dimethyl‐1 H‐imidazol‐3‐ium)) adopts two different binding states (binding states I and II) in its interactions with calf‐thymus (ct‐) DNA. Two distinct binding states were identified by biphasic UV/Vis and circular dichroism (CD) spectral changes during the titration of DNA into the carbazole ligand. At low concentrations of ct‐DNA, (Im+)2Cz binds to nearly every part of ct‐DNA (binding state I). By contrast, an increased concentration of ct‐DNA results in a switch in the DNA‐binding state, so that the ligands are bound per five DNA base pairs. Similarly, a monocationic carbazole ligand (Im+Cz: 2‐((6‐bromo‐9‐ethyl‐9 H‐carbazol‐3‐yl)ethynyl)‐1,3‐dimethyl‐1 H‐imidazol‐3‐ium) also shows biphasic UV/Vis spectral changes during the titration of ct‐DNA into Im+Cz, which suggests two different binding states of the Im+Cz ligand with ct‐DNA. The stepwise equilibrium of the ligand–DNA‐complex formation is capable of switching the thermal stability of ct‐DNA, as well as the enzymatic activity of deoxyribonuclease (DNase I). In binding state I, the (Im+)2Cz ligands interact with nearly every base pair in ct‐DNA and stabilize the double‐helix structure, which results in a larger increase in the melting temperature of the ct‐DNA than that observed with binding state II. On the other hand, the (Im+)2Cz ligand significantly reduces the enzymatic activity of DNase I in binding state I, although the enzymatic activity is recovered once the binding state of the ligand–DNA complex is changed to binding state II. The (Im+)2Cz ligand was also employed as a binder for G‐quadruplex DNA. In contrast to the stepwise complex formation between (Im+)2Cz and ct‐DNA, (Im+)2Cz shows a monotonous UV/Vis spectral response during the titration of G‐quadruplex DNA into (Im+)2Cz, which suggests a single binding state for (Im+)2Cz with G‐quadruplex DNA.
Ionic Liquid Assisted Synthesis of Au–Pd Bimetallic Particles with Enhanced Electrocatalytic Activity
Authors: Li Zhonghao , Li Rui , Mu Tiancheng , Luan Yuxia 
Published: March 2013

AbstractMorphology‐ and composition‐controlled synthesis of Au–Pd bimetallic particles was realized by a facile ionic liquid assisted route at room temperature. The morphologies of the synthesized particles, such as nanoflake‐constructed spheres with a core–shell structure, nanoparticle‐constructed spheres, and nanoparticle‐constructed dendrites, could be well controlled by the present route. The ionic liquid was found to play a key role in the formation of these interesting particles. Moreover, the composition (Au:Pd) of the particles could be modulated by means of the molar ratio of the metal precursors in the feeding solutions. The Au–Pd bimetallic particles exhibit high electrocatalytic activity toward oxidation of ethanol and formic acid. Furthermore, cyclic voltammetric studies on the as‐prepared Au–Pd bimetallic particles revealed good electroactivity for H2O2, which results in an effective amperometric H2O2 sensor.
ChemInform Abstract: Hydrothermal Synthesis and Luminescent Properties of NaLa(MoO4)2:Eu3+,Tb3+ Phosphors.
Authors: Li Guanghuan , Li Linlin , Li Mengmeng , Bao Weiwei , Song Yanhua , Gan Shucai , Zou Haifeng , Xu Xuechun 
Published: March 2013

AbstractNaLa0.96 (MoO4)2:0.02Eu3+,0.02Tb3+ phosphors are hydrothermally prepared from aqueous solutions of La(NO3)3, Eu(NO3)3, Tb(NO3)3, and Na2MoO4.
ChemInform Abstract: Foamlike Porous Spinel MnxCo3‐xO4 Material Derived from Mn3[Co(CN)6]2·nH2O Nanocubes: A Highly Efficient Anode Material for Lithium Batteries.
Authors: Hu Lin , Zhang Ping , Zhong Hao , Zheng Xinrui , Yan Nan , Chen Qianwang 
Published: March 2013

AbstractSpinel MnxCo3‐xO4 porous nanocubes are synthesized for the first time by decomposition of Mn3[Co(CN)6]2·nH2O at 400 °C for 1 h.
ChemInform Abstract: Synthesis and Crystal Structure of Cubic V11Cu9Ga46 — A 512‐Fold Super Structure of a Simple bcc Packing.
Authors: Lux Rainer , Kuntze Verena , Hillebrecht Harald 
Published: March 2013

AbstractSingle crystals of the new title compound are prepared from the elements with a great excess of Ga (evacuated silica tube, 1000 °C, 14 d; controlled cooling).
ChemInform Abstract: Lewis Acid Mediated [3 + 2] Cycloadditions of Donor—Acceptor Cyclopropanes with Heterocumulenes.
Authors: Goldberg Alexander F. G. , O'Connor Nicholas R. , Craig Robert A. II , Stoltz Brian M. 
Published: March 2013

AbstractThe title reaction provides an effective approach to cyclic thioimidates, cyclic amidines, and pyrrolidinones.
ChemInform Abstract: Application of Ruthenium Complexes of Triazole‐Containing Tridentate Ligands to Asymmetric Transfer Hydrogenation of Ketones.
Authors: Johnson Tarn C. , Totty William G. , Wills Martin 
Published: March 2013

AbstractThe catalyst combination efficiently promotes the asymmetric reduction of various acetophenones including ortho‐substituted ones.
ChemInform Abstract: Asymmetric Addition of Alkoxy Ethynyl Anion to Chiral N‐Sulfinyl Imines.
Authors: Verrier Charlie , Carret Sebastien , Poisson Jean‐Francois 
Published: March 2013

AbstractThe addition of boron trifluoride reverses completely the diastereoselectivity [cf.(III) versus (VII)].
ChemInform Abstract: Improved Air‐Stable Solid Aromatic and Heterocyclic Zinc Reagents by Highly Selective Metalations for Negishi Cross‐Couplings.
Authors: Stathakis Christos I. , Bernhardt Sebastian , Quint Valentin , Knochel Paul 
Published: March 2013

AbstractThe presented pool of new and easy‐to‐handle solid organozinc pivalates exhibit excellent reactivity in Negishi cross‐coupling with a broad selection of electrophiles.
ChemInform Abstract: Tetraflic Acid (1,1,2,2‐Tetrafluoroethanesulfonic Acid, HC2F4SO3H) and Gallium Tetraflate as Effective Catalysts in Organic Synthesis.
Authors: Prakash G. K. Surya , Mathew Thomas , Panja Chiradeep , Kulkarni Aditya , Olah George A. , Harmer Mark A. 
Published: March 2013

AbstractThe acid is used to promote transformations which require high acidity like rearrangement or halogenation.
ChemInform Abstract: A Highly anti‐Selective Asymmetric Henry Reaction Catalyzed by a Chiral Copper Complex: Applications to the Syntheses of (+)‐Spisulosine and a Pyrroloisoquinoline Derivative.
Authors: Xu Kun , Lai Guoyin , Zha Zhenggen , Pan Susu , Chen Huanwen , Wang Zhiyong 
Published: March 2013

AbstractIn course of this study the reaction is also conducted in water for the first time.
ChemInform Abstract: Palladium‐Catalyzed Allylation of 2,2,2‐Trifluoroethyl Phenyl Sulfone, a Potential 2,2,2‐Trifluoroethyl Pronucleophile.
Authors: Zhang Wei , Zhao Yanchuan , Ni Chuanfa , Mathew Thomas , Hu Jinbo 
Published: March 2013

AbstractStructurally diverse allylic carbonates (I) are reacted with sulfone (II) under neutral conditions.
ChemInform Abstract: Morita—Baylis—Hillman Reaction of Chiral Highly Oxygenated Cyclopent‐2‐enones.
Authors: Masusai Chonticha , Soorukram Darunee , Kuhakarn Chutima , Tuchinda Patoomratana , Pakawatchi Chaveng , Reutrakul Vichai , Pohmakotr Manat 
Published: March 2013

AbstractThe treatment of substrates of type (I) with aldehydes provides diastereomeric mixtures of the MBH adducts.
ChemInform Abstract: Copper‐Catalyzed Coupling of 1,2‐Dibromo‐1‐styrenes with Sulfonamides for the Preparation of Ynamides.
Authors: Yang Yuan , Zhang Xiaoyun , Liang Yun 
Published: March 2013

AbstractDehydrobromination of dibromoalkenes generates alkynyl bromides which couple with nitrogen nucleophiles to form ynamides.
ChemInform Abstract: Asymmetric 1,2‐Reduction of Enones with Potassium Borohydride Catalyzed by Chiral N,N′‐Dioxide—Scandium(III) Complexes.
Authors: He Peng , Liu Xiaohua , Zheng Haifeng , Li Wei , Lin Lili , Feng Xiaoming 
Published: March 2013

AbstractLabeling experiments prove the source of the hydrogen atom to be KBH4.
ChemInform Abstract: Cross‐Linked‐Polymer‐Supported N‐{2′‐[(Arylsulfonyl)amino][1,1′‐binaphthalen]‐2‐yl}prolinamide as Organocatalyst for the Direct Aldol Intermolecular Reaction under Solvent‐Free Conditions.
Authors: Banon‐Caballero Abraham , Guillena Gabriela , Najera Carmen 
Published: March 2013

AbstractThe catalyst (I) can be recovered and reused up to 7 times without detrimental effects on diastereo‐ and enantioselectivities.
ChemInform Abstract: Pd/Cu‐Catalyzed Oxidation of Alkynes into 1,2‐Diketones Using DMSO as the Oxidant.
Authors: Gao Ang , Yang Fan , Li Ji , Wu Yangjie 
Published: March 2013

AbstractA new and facile pathway to 1,2‐diketones is developed under ligand‐ and additive‐free conditions.