bluuebunny/crossref_metadata_2025_split huggingface dataset:
History of depression but not current depression is associated with signs of atherosclerosis: data from the Gutenberg Health Study
Authors: Beutel M. E. , Wiltink J. , Kirschner Y. , Sinning C. , Espinola-Klein C. , Wild P. S. , Münzel T. , Blettner M. , Zwiener I. , Lackner K. , Michal M. 
Published: July 2013

ObjectivesTo test the vascular depression hypothesis in the general population, we analyzed the association between current depression, medical history of depression, cognitive and somatic depressive symptom dimensions and measures of atherosclerosis [intima–media thickness (IMT) and carotid plaques].MethodWe included a representative sample of 5000 participants from the Gutenberg Health Study (GHS). Depression was assessed by the nine-item Patient Health Questionnaire (PHQ-9), and IMT and carotid plaques were measured at both common carotid arteries using an edge detection system. Regression analyses were performed separately for participants with and without cardiovascular disease, adjusting for medical history, cardiovascular risk factors and psychotropic medication.ResultsContrary to hypotheses, we found no increased IMT for somatic symptoms of depression; the same was true for depression and cognitive symptoms in the fully adjusted model. Only a moderate relationship between medical history of depression and the presence of atherosclerotic plaques was maintained after correction.ConclusionsThe relationship between depression and atherosclerosis may be more complex than previously assumed. Although the vascular depression hypothesis was not supported, our results support the hypothesis that lasting depression leads to arteriosclerosis.
A Forced Hand: Natives, Africans, and the Population of Brazil, 1545-1850
Authors: Bucciferro Justin R. 
Published: July 2013

ABSTRACTThe settlement and expansion of the Portuguese colonies in South America were made possible by slave labour; however, the historical size of enslaved Native and African groups is largely unknown. This investigation compiles extant statistics on the population of «Brazil» by race and state for the pre-census period from 1545 to 1850, complementing them with headcount estimates based on sugar, gold, and coffee production; pre-contact indigenous populations; and trans-Atlantic slave voyages. The resulting panel of demographic data illustrates national and regional racial transitions encompassing the colonial era. Brazil's population was of Native descent but became predominantly African in the 18th century; people of European ancestry remained a minority for another 200 years.
The interaction of gesture, intonation, and eye-gaze in proto-imperatives
Authors: CAMERON-FAULKNER THEA 
Published: July 2013

ABSTRACTIn the present study we investigate the production of gesture, intonation, and eye-gaze within the proto-imperative behaviour of one English child aged 1;0 to 1;7. The study is based on the qualitative and quantitative analysis of the three behaviours. The results indicate a shift from reaching gestures to points, and from rising terminal pitch contours to non-rising contours. The analysis also highlights changes in eye-gaze to the co-participant over time. In addition we identify a significant relationship between pitch contour and gesture type within the sample, with points being more closely associated with non-rise intonation than reaching gestures. We suggest that the changes in proto-imperative behaviour signal a shift in the underlying representation of the function from a request for help to a demand for a particular object, and that this development paves the way for the subsequent conventional linguistic expression of the imperative function.
Congenital toxoplasmosis in the state of Minas Gerais, Brazil: a neglected infectious disease?
Authors: CARELLOS E. V. M. , CAIAFFA W. T. , ANDRADE G. M. Q. , ABREU M. N. S. , JANUÁRIO J. N. 
Published: July 2013

SUMMARYThis study aimed to investigate the distribution of congenital toxoplasmosis in the state of Minas Gerais, Southeastern Brazil and describe the demographic and socioeconomic profile of the municipalities associated with the disease. An ecological study was conducted using socioeconomic indicators of a database (MGSSRI) created by Fundação João Pinheiro (a government technical support agency of Minas Gerais), in order to show the development of the municipalities in the state. The prevalence of toxoplasmosis was the outcome and the items of the MGSSRI were the explanatory variables. Of 146 307 newborns screened (November 2006 to May 2007), 190 had congenital toxoplasmosis, yielding a prevalence of 1·3/1000, ranging from 0 to 76·9/1000 in the municipalities. The multivariate model indicated a higher occurrence of toxoplasmosis in municipalities with smaller populations and worse indexes of tax performance. Congenital toxoplasmosis appears to be a neglected disease in the state of Minas Gerais, given the high prevalence found and its concentration in municipalities with worse socioeconomic indexes.
Identifying the high-risk areas and associated meteorological factors of dengue transmission in Guangdong Province, China from 2005 to 2011
Authors: FAN J. , LIN H. , WANG C. , BAI L. , YANG S. , CHU C. , YANG W. , LIU Q. 
Published: July 2013

SUMMARYWe examined the spatial distribution pattern and meteorological drivers of dengue fever (DF) in Guangdong Province, China. Annual incidence of DF was calculated for each county between 2005 and 2011 and the geographical distribution pattern of DF was examined using Moran's I statistic and excess risk maps. A time-stratified case-crossover study was used to investigate the short-term relationship between DF and meteorological factors and the Southern Oscillation Index (SOI). High-epidemic DF areas were restricted to the Pearl River Delta region and the Han River Delta region, Moran's I of DF distribution was significant from 2005 to 2006 and from 2009 to 2011. Daily vapour pressure, mean and minimum temperatures were associated with increased DF risk. Maximum temperature and SOI were negatively associated with DF transmission. The risk of DF was non-randomly distributed in the counties in Guangdong Province. Meteorological factors could be important predictors of DF transmission.
Demonstration of the spin solar cell and spin photodiode effect
Authors: Endres B. , Ciorga M. , Schmid M. , Utz M. , Bougeard D. , Weiss D. , Bayreuther G. , Back C.H. 
Published: July 2013

AbstractSpin injection and extraction are at the core of semiconductor spintronics. Electrical injection is one method of choice for the creation of a sizeable spin polarization in a semiconductor, requiring especially tailored tunnel or Schottky barriers. Alternatively, optical orientation can be used to generate spins in semiconductors with significant spin-orbit interaction, if optical selection rules are obeyed, typically by using circularly polarized light at a well-defined wavelength. Here we introduce a novel concept for spin injection/extraction that combines the principle of a solar cell with the creation of spin accumulation. We demonstrate that efficient optical spin injection can be achieved with unpolarized light by illuminating a p-n junction where the p-type region consists of a ferromagnet. The discovered mechanism opens the window for the optical generation of a sizeable spin accumulation also in semiconductors without direct band gap such as Si or Ge.
Severing and end-to-end annealing of neurofilaments in neurons
Authors: Uchida Atsuko , Çolakoğlu Gülsen , Wang Lina , Monsma Paula C. , Brown Anthony 
Published: July 2013

Significance
Neurofilaments, which are the intermediate filaments of neurons, are major components of nerve cells, but their assembly dynamics have not been determined. Here we demonstrate efficient end-to-end annealing of neurofilaments in nerve cells, and we show that there also is a mechanism that severs these polymers. Our efforts thus identify severing of neuronal intermediate filaments in vivo and suggest a mechanism for regulating intermediate filament length involving a dynamic cycle of severing and end-to-end annealing.
Data-based filtering for replicated high-throughput transcriptome sequencing experiments
Authors: Rau Andrea , Gallopin Mélina , Celeux Gilles , Jaffrézic Florence 
Published: July 2013

AbstractMotivation: RNA sequencing is now widely performed to study differential expression among experimental conditions. As tests are performed on a large number of genes, stringent false-discovery rate control is required at the expense of detection power. Ad hoc filtering techniques are regularly used to moderate this correction by removing genes with low signal, with little attention paid to their impact on downstream analyses.Results: We propose a data-driven method based on the Jaccard similarity index to calculate a filtering threshold for replicated RNA sequencing data. In comparisons with alternative data filters regularly used in practice, we demonstrate the effectiveness of our proposed method to correctly filter lowly expressed genes, leading to increased detection power for moderately to highly expressed genes. Interestingly, this data-driven threshold varies among experiments, highlighting the interest of the method proposed here.Availability: The proposed filtering method is implemented in the R package HTSFilter available on Bioconductor.Contact: andrea.rau@jouy.inra.frSupplementary information: Supplementary data are available at Bioinformatics online.
Identification of a New Class of Lipid Droplet-Associated Proteins in Plants
Authors: Horn Patrick J. , James Christopher N. , Gidda Satinder K. , Kilaru Aruna , Dyer John M. , Mullen Robert T. , Ohlrogge John B. , Chapman Kent D. 
Published: July 2013

Abstract
Lipid droplets in plants (also known as oil bodies, lipid bodies, or oleosomes) are well characterized in seeds, and oleosins, the major proteins associated with their surface, were shown to be important for stabilizing lipid droplets during seed desiccation and rehydration. However, lipid droplets occur in essentially all plant cell types, many of which may not require oleosin-mediated stabilization. The proteins associated with the surface of nonseed lipid droplets, which are likely to influence the formation, stability, and turnover of this compartment, remain to be elucidated. Here, we have combined lipidomic, proteomic, and transcriptomic studies of avocado (Persea americana) mesocarp to identify two new lipid droplet-associated proteins, which we named LDAP1 and LDAP2. These proteins are highly similar to each other and also to the small rubber particle proteins that accumulate in rubber-producing plants. An Arabidopsis (Arabidopsis thaliana) homolog to LDAP1 and LDAP2, At3g05500, was localized to the surface of lipid droplets after transient expression in tobacco (Nicotiana tabacum) cells that were induced to accumulate triacylglycerols. We propose that small rubber particle protein-like proteins are involved in the general process of binding and perhaps the stabilization of lipid-rich particles in the cytosol of plant cells and that the avocado and Arabidopsis protein members reveal a new aspect of the cellular machinery that is involved in the packaging of triacylglycerols in plant tissues.
Child speech, language and communication need re‐examined in a public health context: a new direction for the speech and language therapy profession
Authors: Law James , Reilly Sheena , Snow Pamela C. 
Published: July 2013

AbstractBackgroundHistorically speech and language therapy services for children have been framed within a rehabilitative framework with explicit assumptions made about providing therapy to individuals. While this is clearly important in many cases, we argue that this model needs revisiting for a number of reasons. First, our understanding of the nature of disability, and therefore communication disabilities, has changed over the past century. Second, there is an increasing understanding of the impact that the social gradient has on early communication difficulties. Finally, understanding how these factors interact with one other and have an impact across the life course remains poorly understood.AimsTo describe the public health paradigm and explore its implications for speech and language therapy with children.Methods & ProceduresWe test the application of public health methodologies to speech and language therapy services by looking at four dimensions of service delivery: (1) the uptake of services and whether those children who need services receive them; (2) the development of universal prevention services in relation to social disadvantage; (3) the risk of over‐interpreting co‐morbidity from clinical samples; and (4) the overlap between communicative competence and mental health.Outcomes & ConclusionsIt is concluded that there is a strong case for speech and language therapy services to be reconceptualized to respond to the needs of the whole population and according to socially determined needs, focusing on primary prevention. This is not to disregard individual need, but to highlight the needs of the population as a whole. Although the socio‐political context is different between countries, we maintain that this is relevant wherever speech and language therapists have a responsibility for covering whole populations. Finally, we recommend that speech and language therapy services be conceptualized within the framework laid down in The Ottawa Charter for Health Promotion.
The roles of extracellularDNAin the structural integrity of extracellular polymeric substance and bacterial biofilm development
Authors: Das Theerthankar , Sehar Shama , Manefield Mike 
Published: July 2013

SummaryBacteria adhere to natural and engineered surfaces and develop into mature biofilms encased in self‐produced extracellular polymeric substances (EPSs).EPSconsists of polysaccharides, proteins, metabolites and extracellularDNA(eDNA). ExtracellularDNArelease by bacteria is mediated by both quorum‐sensing (QS)‐dependent and ‐independent mechanisms. Quorum‐sensing‐independent mechanisms are responsible for basal levels ofeDNArelease, whereasQS‐dependent mechanisms control the production of prophages, phenazines and proteins involved in cell lysis and subsequent release of elevated amounts ofeDNA. ExtracellularDNAbinds with other biopolymers such as polysaccharides, proteins or metabolites like phenazines, thereby providing structural integrity toEPS. ExtracellularDNApromotes attractive acid–base interactions between bacterial cells and between bacteria and surfaces. It therefore plays an essential structural role in stabilising biofilms and protecting bacterial cells from physical and chemical challenges. Accordingly, with current knowledge, it becomes clear that targeting and destroyingeDNAin bacterialEPSis a promising strategy for treatment of bacterial‐associated infections in a medical context and biofilm control on surfaces to prevent biocorrison in an engineering context. In contrast, the addition ofDNAcan be applied to engineering of biofilms for beneficial purposes such as remediation of environmental pollutants and electricity or fuel production in bioelectrochemical systems or bioreactors.
Cost‐effectiveness of CBT, SSRI, and CBT+SSRI in the treatment for panic disorder
Authors: van Apeldoorn F. J. , Stant A. D. , van Hout W. J. P. J. , Mersch P. P. A. , den Boer J. A. 
Published: July 2013

ObjectiveThe objective of this study was to assess the cost‐effectiveness of three empirically supported treatments for panic disorder with or without agoraphobia: cognitive behavioral therapy (CBT), pharmacotherapy using a selective serotonin reuptake inhibitor (SSRI), or the combination of both (CBT+SSRI).MethodCost‐effectiveness was examined based on the data from a multicenter randomized controlled trial. The Hamilton Anxiety Rating Scale was selected as a primary health outcome measure. Data on costs from a societal perspective (i.e., direct medical, direct non‐medical, and indirect non‐medical costs) were collected in the study sample (N = 150) throughout a 24‐month period in which patients received active treatment during the first twelve months and were seen twice for follow‐up in the next twelve months.ResultsTotal costs were largely influenced by costs of the interventions and productivity losses. The mean total societal costs were lower for CBT as compared to SSRI and CBT+SSRI. Costs of medication use were substantial for both SSRI and CBT+SSRI. When examining the balance between costs and health outcomes, both CBT and CBT+SSRI led to more positive outcomes than SSRI.ConclusionCognitive behavioral therapy is associated with the lowest societal costs. Cognitive behavioral therapy and CBT+SSRI are more cost‐effective treatments for panic disorder with or without agoraphobia as compared to SSRI only.
Establishing a Method for In Vitro Investigation of Mechanical Parameters Causing Acquired von Willebrand Syndrome in Ventricular Assist Devices
Authors: Egger Christina , Maas Judith , Hufen Tristan , Schmitz‐Rode Thomas , Steinseifer Ulrich 
Published: July 2013

AbstractAcquired von Willebrand Syndrome (AvWS) is known as a frequent bleeding complication in patients on ventricular assist device (VAD) support. Clinicians demand that the requirements for VADs with regard to hemocompatibility should also include low susceptibility for AvWS. Clinical AvWS diagnosis is known to be a complex, high‐price, and time‐consuming analysis. This article investigates an easy‐to‐handle, time‐efficient, and inexpensive method for comparative AvWS investigations in vitro. Von Willebrand Factor activity level (vWF : Ac) and von Willebrand Factor antigen level (vWF : Ag) were chosen from the complete set of clinically established parameters. Blood plasma (human and porcine) was exposed to an inhomogeneous shear field in a shear‐inducing test set up for up to 4 h. Plasma samples were drawn after different load periods and analyzed for vWF : Ac and vWF : Ag. vWF multimer analysis of selected samples were used as reference for determination of high molecular weight multimer (HMWM) loss. AvWS was detected after 20 min of shear load via vWF : Ac/vWF : Ag ratio and multimer analysis. A good correlation between the vWF : Ac/vWF : Ag ratio and HMWM loss (multimer analysis) was found for human plasma. AvWS characteristics of human and porcine plasma for analyzed samples were comparable. A correlation between vWF : Ac/vWF : Ag ratio and HMWM in porcine plasma could not be found. Results gained in this study indicate that vWF : Ac/vWF : Ag ratio is sensitive enough for comparative AvWS investigations in vitro with human blood. The applicability of the method suggested in this article for AvWS characterization in porcine blood needs to be investigated in further studies. The selection of analysis kits promises a less cost‐ and labor‐intensive, time‐consuming, and complex method for comparative AvWS investigations in vitro compared with AvWS diagnosis in patients.
Variable Pay, Industrial Relations and Foreign Ownership: Evidence from Germany
Authors: Heywood John S. , Jirjahn Uwe 
Published: July 2013

AbstractWe use a representative sample of German establishments to show that those with foreign ownership are more likely to use performance appraisal, profit‐sharing and employee share ownership than those with domestic ownership. Moreover, we show that works councils are associated with an increased probability of using each of the three practices when under domestic ownership but not when under foreign ownership. These results inform the ongoing debate over institutional duality, the extent to which foreign firms adopt uniform practices independent of local institutions, and the extent to which they adapt and participate in those local institutions.
Disturbance History of a Seasonal Tropical Forest in Western Thailand: A Spatial Dendroecological Analysis
Authors: Middendorp Romaike S. , Vlam Mart , Rebel Karin T. , Baker Patrick J. , Bunyavejchewin Sarayudh , Zuidema Pieter A. 
Published: July 2013

AbstractDisturbances play an important role in forest dynamics across the globe. Researchers have mainly focused on the temporal context of disturbances, but have largely ignored the spatial patterns of tree recruitment they create. Geostatistical tools enable the analysis of spatial patterns and variability in tropical forest disturbance histories. Here, we examine the potential of combining dendroecological analysis and spatial statistics to reconstruct the disturbance history of a seasonal dry evergreen tropical forest plot at the Huai Kha Khaeng Wildlife Sanctuary (HKK), western Thailand. We used tree‐ring‐derived age estimates for 70 individuals of the shade‐intolerant pioneer speciesMelia azederach(Meliaceae) and tree locations across a 316‐ha study plot to identify the timing and spatial extent of past disturbances. Although the age distribution forMeliasuggested that regeneration had been continuous over the past 60 yr, spatial analyses (mark correlation function and kriging) demonstrated the presence of three spatially discrete age cohorts. Two of these cohorts suggested a severe disturbance ~20 yr before present. A third cohort appears to have established ~50 years ago. Using historical records, we conclude that fire disturbance is the most likely disturbance factor affectingHKK. Nevertheless, we do not rule out other disturbance factors. The combined application of tree‐ring analysis and spatial statistics as applied in this study could be readily applied to reconstruct disturbance histories in other tropical regions where tree species with annual growth rings are present.
Does vitamin D3 supplementation improve glucose homeostasis in overweight or obese women? A double‐blind, randomized, placebo‐controlled clinical trial
Authors: Salehpour A. , Shidfar F. , Hosseinpanah F. , Vafa M. , Razaghi M. , Amiri F. 
Published: July 2013

AbstractAimsVitamin D deficiency is considered as a risk factor in cardiometabolic disorders, including cardiovascular diseases, hypertension and Type 2 diabetes mellitus. We have investigated the effect of vitamin D3 supplementation on glucose homeostasis in healthy overweight and obese women.MethodsIn a double‐blind randomized placebo‐controlled clinical trial, 77 healthy overweight or obese women (mean age 38 ± 8 years; BMI 29.9 ± 4.2 kg/m2) were randomly assigned to the vitamin D3 group (25 μg/day as cholecalciferol tablets) or the placebo group. Selected anthropometric indices, glucose, insulin, HbA1c and homeostasis model assessment of insulin resistance at baseline and after 12 weeks were measured. Dietary intakes using 24‐h food recall and food frequency questionnaires were assessed. Physical activity was assessed by the International Physical Activity Questionnaire. Adjusted mean differences were calculated using analysis of covariance. Correlation coefficients were calculated by Pearson's analysis.ResultsMean fasting blood glucose concentrations declined in the vitamin D3 and placebo groups (–0.28 ± 0.4 vs. –0.65 ± 0.4 mmol/l, P < 0.001) and the mean percentage of HbA1c was decreased (–13 ± 18 vs. –19 ± 17 mmol/l, P = 0.06) in both groups, respectively. Mean 25‐hydroxyvitamin D concentrations increased in the vitamin D3 and placebo groups (38.2 ± 32 vs. 4.6 ± 14 nmol/l, P < 0.001), respectively. There was a significant correlation between HbA1c and 25‐hydroxyvitamin D concentrations (r = –0.271; P = 0.018).ConclusionsThe results indicate that the vitamin D3 supplement of 25 μg/day had no beneficial effect on glycaemic indices in healthy overweight or obese women.