bluuebunny/crossref_metadata_2025_split huggingface dataset:
Habitual Coffee, Tea, and Caffeine Consumption, Circulating Metabolites, and the Risk of Cardiometabolic Multimorbidity
Authors: Lu Xujia , Zhu Xiaohong , Li Guochen , Wu Luying , Shao Liping , Fan Yulong , Pan Chen-Wei , Wu Ying , Borné Yan , Ke Chaofu 
Published: August 2024

AbstractContextCardiometabolic multimorbidity (CM) is an increasing public health concern. Previous observational studies have suggested inverse associations between coffee, tea, and caffeine intake and risks of individual cardiometabolic diseases; however, their associations with CM and related biological markers are unknown.MethodsThis prospective study involved 172 315 (for caffeine analysis) and 188 091 (tea and coffee analysis) participants free of any cardiometabolic diseases at baseline from the UK Biobank; 168 metabolites were measured among 88 204 and 96 393 participants. CM was defined as the coexistence of at least 2 of the following conditions: type 2 diabetes, coronary heart disease, and stroke.ResultsNonlinear inverse associations of coffee, tea, and caffeine intake with the risk of new-onset CM were observed. Compared with nonconsumers or consumers of less than 100 mg caffeine per day, consumers of moderate amount of coffee (3 drinks/d) or caffeine (200-300 mg/d) had the lowest risk for new-onset CM, with respective hazard ratios (95% CIs) of 0.519 (0.417-0.647) and 0.593 (0.499-0.704). Multistate models revealed that moderate coffee or caffeine intake was inversely associated with risks of almost all developmental stages of CM, including transitions from a disease-free state to single cardiometabolic diseases and subsequently to CM. A total of 80 to 97 metabolites, such as lipid components within very low-density lipoprotein, histidine, and glycoprotein acetyls, were identified to be associated with both coffee, tea, or caffeine intake and incident CM.ConclusionHabitual coffee or caffeine intake, especially at a moderate level, was associated with a lower risk of new-onset CM and could play important roles in almost all transition phases of CM development. Future studies are warranted to validate the implicated metabolic biomarkers underlying the relation between coffee, tea, and caffeine intake and CM.
Neonatal Severe Hyperparathyroidism Causing Life-Threatening Hypercalcemia Treated With Medical and Surgical Management
Authors: Rosettenstein Kerri , Parasyn Andrew , Neville Kristen , Hameed Shihab 
Published: August 2024

Abstract
A 3-day-old male presented to a peripheral remote hospital in New South Wales, Australia, with tachypnea. He was found to have hypercalcemia, with ionized calcium &gt;2.5 mmol/L (&gt;10 mg/dL) (0.97-1.5 mmol/L or 1.14-1.3 mg/dL) and serum calcium of 3.85 mmol/L (15.43 mg/dL) (2.2-2.8 mmol/L or 8.5-10.5 mg/dL). Peak serum calcium was 5.4 mmol/L (21.64 mg/dL). He was transferred to a tertiary pediatric intensive care unit. Medical management (including hyperhydration, diuretics, corticosteroids, bisphosphonates, cinacalcet, and calcitonin) failed to maintain normocalcemia; therefore, total parathyroidectomy was performed on day 16 of life. Hungry bones syndrome developed postoperatively, requiring high doses of calcium, calcitriol, and phosphate supplementation. Genetic testing identified compound heterozygosity for 2 likely pathogenic variants in the calcium-sensing receptor gene. He is now 3 years old and is growing and developing without any concerns. This case highlights the importance of aggressive initial management in addressing severe hypercalcemia through perioperative management principles as well as the prolonged nature of hungry bones syndrome.
Rapid Resolution of Recalcitrant Headache With Pasireotide in an Adult Patient With Acromegaly
Authors: Dabbous Zeinab , Rohani Zaina , Abdalrubb Abeer Kaled , Alkailani Yaman , Pivonello Rosario , Elhadd Tarik 
Published: August 2024

Abstract
Acromegaly is a chronic hormonal disorder caused by excessive GH secretion. In addition to physiological symptoms, it is often accompanied by debilitating headaches. Although effective treatment options exist, achieving complete symptom control and disease management can still be challenging. This case report chronicles the clinical journey of a 38-year-old male diagnosed with acromegaly in 2013. Despite prior interventions, including surgery and treatment with first-generation somatostatin analogues, severe frequent headaches persisted. Following a switch to pasireotide, the patient reported rapid and complete resolution of headaches and normalization of IGF-1 levels within a month of the treatment switch. This report underscores the challenges in acromegaly management and confirms the potential utility of pasireotide for patients suffering from treatment-resistant headache.
Pandemic Times and Health Care Exclusion: Attitudes toward Health Care Exclusion of Undocumented Immigrants
Authors: Nunez Cesar Vargas 
Published: August 2024

Abstract
Context: Most of the 11 million undocumented immigrants living in the United States are excluded from government health care programs. Yet, health care inequities pose significant dangers to all members of society during a pandemic. This project explores to what extent undocumented immigrants, in the context of a pandemic, can be seen as deserving of access to government health care programs.
Methods: The project's first survey experiment explores whether work ethic can affect perceptions of undocumented immigrants as deserving of government health care programs. The second survey experiment tests to what extent appeals to fairness and self-interest, during a pandemic, shape health care deservingness attitudes.
Findings: The results show that respondents view undocumented immigrants as less deserving of health care than citizens, even when undocumented immigrants have a solid work history. The second survey experiment, however, shows that appeals to fairness and self-interest trigger substantial increases in support for undocumented immigrants among both Republicans and Democrats.
Conclusions: The results suggest that while undocumented immigrants are seen as less deserving of access, appeals to fairness and self-interest can trigger increased support.
Mitochondrial dynamics regulate cell morphology in the developing cochlea
Authors: O'Sullivan James D. B. , Terry Stephen , Scott Claire A. , Bullen Anwen , Jagger Daniel J. , Mann Zoë F. 
Published: August 2024

ABSTRACT
In multicellular tissues, the size and shape of cells are intricately linked with their physiological functions. In the vertebrate auditory organ, the neurosensory epithelium develops as a mosaic of sensory hair cells (HCs), and their glial-like supporting cells, which have distinct morphologies and functional properties at different frequency positions along its tonotopic long axis. In the chick cochlea, the basilar papilla (BP), proximal (high-frequency) HCs, are larger than their distal (low-frequency) counterparts, a morphological feature essential for sound perception. Mitochondrial dynamics, which constitute the equilibrium between fusion and fission, regulate differentiation and functional refinement across a variety of cell types. We investigate this as a potential mechanism for regulating the shape of developing HCs. Using live imaging in intact BP explants, we identify distinct remodelling of mitochondrial networks in proximal compared with distal HCs. Manipulating mitochondrial dynamics in developing HCs alters their normal morphology along the proximal-distal (tonotopic) axis. Inhibition of the mitochondrial fusion machinery decreased proximal HC surface area, whereas promotion of fusion increased the distal HC surface area. We identify mitochondrial dynamics as a key regulator of HC morphology in developing inner ear epithelia.
Nucleocytoplasmic transport senses mechanical forces independently of cell density in cell monolayers
Authors: Granero-Moya Ignasi , Venturini Valeria , Belthier Guillaume , Groenen Bart , Molina-Jordán Marc , González-Martín Miguel , Trepat Xavier , van Rheenen Jacco , Andreu Ion , Roca-Cusachs Pere 
Published: August 2024

ABSTRACT
Cells sense and respond to mechanical forces through mechanotransduction, which regulates processes in health and disease. In single adhesive cells, mechanotransduction involves the transmission of force from the extracellular matrix to the cell nucleus, where it affects nucleocytoplasmic transport (NCT) and the subsequent nuclear localization of transcriptional regulators, such as YAP (also known as YAP1). However, if and how NCT is mechanosensitive in multicellular systems is unclear. Here, we characterize and use a fluorescent sensor of nucleocytoplasmic transport (Sencyt) and demonstrate that NCT responds to mechanical forces but not cell density in cell monolayers. Using monolayers of both epithelial and mesenchymal phenotype, we show that NCT is altered in response both to osmotic shocks and to the inhibition of cell contractility. Furthermore, NCT correlates with the degree of nuclear deformation measured through nuclear solidity, a shape parameter related to nuclear envelope tension. In contrast, YAP is sensitive to cell density, showing that the YAP response to cell–cell contacts is not via a mere mechanical effect of NCT. Our results demonstrate the generality of the mechanical regulation of NCT.
The Effects of Real-Time Feedback on Effort and Performance: Evidence from a Natural Quasi-Experiment
Authors: Margolin Maximilian , Reimer Marko , Schaupp Daniel 
Published: August 2024

New digital technologies allow companies to provide employees with performance feedback in real time. We investigate the causal effects of such real-time feedback on individual effort and the quality of initial (prefeedback) and final (postfeedback) decisions by exploiting a natural quasi-experiment in the setting of professional soccer refereeing. Our results suggest that real-time feedback has differential effects for experienced compared with inexperienced agents. Specifically, we find some evidence that experienced agents decrease their effort under real-time feedback without harming the quality of their initial decisions. This results in better final decisions because real-time feedback allows agents to correct wrong initial decisions upon feedback. In contrast, inexperienced agents increase their effort, but make worse initial decisions. Upon feedback, they manage to compensate for their increased number of wrong initial decisions, but see no improvement in the quality of final decisions. This paper was accepted by Ranjani Krishnan, accounting. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.02084 .
Cost-sharing and associated factors in the Peruvian private health care system
Authors: Bellido-Boza Luciana , Villarreal-Zegarra David , Pariona-Cárdenas Max , Carrión Roger , Valdivia-Miranda Paul , Melendez-Torres G. J. 
Published: August 2024

Background
The costs associated with healthcare are of critical importance to both decision-makers and users, given the limited resources allocated to the health sector. However, the available scientific evidence on healthcare costs in low- and middle-income countries, such as Peru, is scarce. In the Peruvian context, the health system is fragmented, and the private health insurance and its financing models have received less research attention. We aimed to analyse user cost-sharing and associated factors within the private healthcare system.

Methods
Our study was cross-sectional, using open data from the Electronic Transaction Model of Standardized Billing Data—TEDEF-SUSALUD, between 2021–2022. Our unit of analysis is the user’s medical bills. We considered the total amount of cost-sharing, proportion of total payments as cost-sharing, and cost-sharing as a proportion of minimum salaries. We use a multiple regression model to perform the analyses.

Results
Our study included 5,286,556 health services provided to users of the private health insurance in Peru. We found a significant difference was observed in the cost-sharing for hospitalization-related services, with an average of 419.64 soles per day (95% CI: 413.44 to 425.85). Also, we identified that for hospitalization-related services per day is, on average, 0.41 (95% CI: 0.41 to 0.41) minimum salaries more expensive than outpatient care, although cost-sharing per day of hospitalization represent on average only 14% of the total amount submitted.

Conclusions
Our study provides a detailed overview of cost-sharing in the private healthcare system in Peru and the factors associated with them. Policymakers can use the study’s finding that higher cost-sharing for inpatient hospitalization compared to outpatient care in private insurance can create inequities in access to healthcare to design policies aimed at reducing these costs and promoting a more equitable and accessible healthcare system in Peru.
Experiences of smoking and tobacco use during pregnancy: A qualitative study protocol
Authors: Agràs-Guàrdia Maria , Martínez-Torres Sara , Satué Eva , Granado-Font Ester , Pallejà-Millán Meritxell , Patricio Demetria , Leiva Miriam , Rey-Reñones Cristina , Martín-Luján Francisco 
Published: August 2024

Tobacco use during pregnancy is the main avoidable cause of morbidity and mortality both for pregnant women and their offspring. Between 12 and 22% of pregnant women in industrialized countries smoke during pregnancy, and 13% are unable to stop smoking. Pregnancy is considered an ideal opportunity to intervene and control tobacco use among smokers and their families. However, pregnant women experience barriers to quitting smoking, including social stigma and fear of being judged. Thus, it is necessary to develop interventions for smoking cessation adapted for pregnant women. This paper presents a qualitative study protocol to assess the barriers and facilitators of smoking cessation during pregnancy that female smokers encounter or perceive. It consists of a series of focus groups and individual interviews with female smokers who have been pregnant within the last five years. Participants will be recruited from the Sexual and Reproductive Health Care Services of the Camp de Tarragona. A group of 5–10 women who have been pregnant and tried to quit smoking over the last 5 years will be selected. The data will be collected by means of semistructured interviews. All interviews will be transcribed verbatim, coded and synthesized into categories and main themes. Thematic analysis will be conducted employing an iterative and reflexive approach. The results of this study will offer new perspectives on smoking interventions for pregnant women and enhance our comprehension of the main barriers to and facilitators of smoking cessation during pregnancy. This will contribute to the adaptation of the Tobbstop app, originally designed for the general public, to suit the needs of pregnant women. Consequently, the creation of targeted interventions will positively influence the health outcomes of both pregnant women and newborns.Trial registration:Clinicaltrials.gov ID:NCT05222958. The trial was registered 3 February 2022, athttps://clinicaltrials.gov/ct2/show/NCT05222958.
Numerical solution of general order Emden-Fowler-type Pantograph delay differential equations
Authors: Albalawi Kholoud Saad , Kumar Ashish , Alqahtani Badr Saad , Goswami Pranay 
Published: August 2024

Abstract
The present study introduces the Haar wavelet method, which utilizes collocation points to approximate solutions to the Emden-Fowler Pantograph delay differential equations (PDDEs) of general order. This semi-analytic method requires the transformation of the original differential equation into a system of nonlinear differential equations, which is then solved to determine the Haar coefficients. The method’s application to fourth-, fifth-, and sixth-order PDDEs is discussed, along with an examination of convergence that involves the determination of an upper bound and the formulation of the rate of convergence for the method. Numerical simulations and error tables are presented to demonstrate the effectiveness and precision of this approach. The error tables clearly illustrate that the method’s accuracy improves progressively with increasing resolution.
Cloning operations and graph diameter
Authors: Iordanskiy Mikhail A. 
Published: August 2024

Abstract
The influence of the subgraph cloning operation on the graph diameter is studied. The corresponding potential increase in the diameter is estimated. Conditions under which the subgraph cloning operation causes no change in the graph diameter are formulated. An example of using the cloning operation to construct a family of fat trees is presented. The diameter of such graphs and the complexity of their design are estimated.
Relations between energy complexity measures of Boolean networks and positive sensitivity of Boolean functions
Authors: Mestetskiy Mikhail A. , Shupletsov Mikhail S. 
Published: August 2024

Abstract
We study relationships between lower estimates for the energy complexity E(Σ), the switching complexity S(Σ) of a normalized Boolean network Σ, and the positive sensitivity ps(f) of the Boolean function f implemented by this circuit. The lower estimate

E
(

Σ

)
⩾
⌊

ps
(
f
)
−
1

m

⌋

$\begin{array}{}
\displaystyle
E({\it\Sigma})\geqslant \lfloor\frac{\text{ps}(f)-1}{m}\rfloor
\end{array}$

is proved for a sufficiently wide class of bases consisting of monotone Boolean functions of at most m variables, the negation gate, and the Boolean constants 0 and 1. For the switching complexity of circuits, we construct a counterexample which shows that, for the standard basis of elements of the disjunction, conjunction, and negation, there do not exist a linear (with respect to ps(f)) lower estimate for the switching complexity.
On the maximal size of tree in a random forest
Authors: Pavlov Yuriy L. 
Published: August 2024

Abstract
Galton-Watson forests consisting of N rooted trees and n non-root vertices are considered. The distribution of the forest is determined by that of critical branching process with infinite variance and regularly varying tail of the progeny distribution. We prove limit theorem for the maximal size of a tree in a forest as N, n → ∞ in such a way that n/N → ∞. Our conditions are significantly wider than was previously known.
On analysing fragments: the case of No?
Authors: Wallage Phillip , van der Wurff Wim 
Published: August 2024

Abstract
This paper addresses the analysis of sentence fragments, specifically the English negative polar response item no. Two main types of synchronic analysis have been proposed for present-day English – one in which yes and no are syntactically inert particles which substitute for a clause, the other in which they are the initial element of an elided clause. Using diachronic data from 15th- to 17th-century English, we argue that the emergence of a novel other-speaker question pattern involving no demonstrates that speakers of early English analysed interrogative polar no as the initial element of a clause with TP-ellipsis. This novel pattern has received little attention in the literature, yet this grammatical innovation is interesting because its emergence demonstrates how diachronic change can be used as a diagnostic for underlying grammatical structure.
Exploring the anti-lung cancer mechanism of Ganoderma lucidum and its relationship with the level of immune cell infiltration based on network pharmacology and molecular docking
Authors: Luo Yuanyuan , Luo Xuehua , Xue Zhijian , Wu Miao , Chen Qiufang , Jin Ling 
Published: August 2024

Abstract

Objectives

Ganoderma lucidum has anti-tumor effects, but its mechanism of action against lung cancer is not clear. This study aims to use molecular docking and network pharmacology to investigate how G. lucidum inhibits tumor growth in lung cancer and how this relationship relates to the degree of immune cell infiltration.

Methods
By utilizing the TCMSP database, the therapeutic targets and active ingredients of G. lucidum were discovered. Based on the targets found in subsequent rounds of screening, a protein interaction (PPI) network was constructed. Additionally, enrichment analysis was conducted using GO and the KEGG. The molecular docking was conducted with the help of AutoDock Tools and PyMOL. Finally, we investigated the relationships between immune cells and the commonalities between lung cancer and.

Results
The primary targets of G. lucidum’s anti-lung cancer activities, according to network pharmacology studies, are ADRB2, OPRM1, SLC6A4, and JUN. The primary components of the lung cancer fighter Ergosterol are ganoderal B, ganolucidic acid E, and beta-sitosterol. The molecular docking analysis revealed that beta-sitosterol had the highest degree of stability in its docking interaction with JUN. The immune infiltration analysis indicated a potential correlation between the biomarkers associated with G. lucidum treatment for lung cancer and the immune infiltrating cells.

Conclusions

G. lucidum combats lung cancer by targeting multiple components and signaling pathways, facilitating cancer cell apoptosis and interacting with immune responses. This elucidates potential avenues for future research into G. lucidum’s mechanisms in lung cancer therapy.
A ver (si): diacronía de un marcador del discurso en español
Authors: Sánchez Jiménez Santiago U. 
Published: August 2024

Abstract
In this work, the diachronic perspective is used to explain the coexistence in current Spanish of three constructions: a) syntactic structures like a ver (si) + complement, integrated into the sentence framework, b) non-sentence fragments like a ver and c) independent structures, like a ver si + sentence complement. Out-side the sentence framework, both non-sentence fragments and independent sen-tences fulfil pragmatic values (interactive) or discursive values (favoring the construction of discourse). To carry out this diachronic investigation, we start from the syntactic insubordination hypothesis (cf. Evans 2007; Evans/Watanabe 2016), assuming that independence structures are the result of their insubordination from the governing nucleus of the sentence framework. In the first place, according to the documentation provided by the Corpus del Diccionario histórico de la lengua española (CDH), it is verified when the integrated syntactic structures like a ver (si) + complement, which we call experimentation structures, begin to be documented and when they stabilize in the language. The body of documents is subsequently reviewed to verify the first cases of syntactic insubordination and to verify how these syntactic independence processes end up being conventionalized and start to function as procedural marks with pragmatic and discursive value.