bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Prevalence of Hereditary Cancer Syndromes in Adolescents and Young Adults With Colorectal Cancer
Authors: Mork Maureen E. , You Y. Nancy , Ying Jun , Bannon Sarah A. , Lynch Patrick M. , Rodriguez-Bigas Miguel A. , Vilar Eduardo 
Published: July 2015

Purpose Established guidelines recommend evaluation for hereditary cancer syndromes in patients younger than 50 years diagnosed with colorectal cancer (CRC). This group has been well described in the literature; however, patients diagnosed as adolescents and young adults are not well represented in CRC studies. Here, we define the clinical profile, including the extent of hereditary cancer syndromes and family history of cancer, in patients diagnosed with CRC at age 35 or younger. Patients and Methods We reviewed patients who underwent genetic counseling at our institution during 5 years (2009 to 2013). Data were collected regarding demographics, clinicopathologic information, tumor and genetic testing, and family history. Patients with an identified hereditary cancer syndrome were compared with those without a syndrome. Results Of the 193 patients with evaluable data, 35% had an identifiable hereditary cancer syndrome, including 23 with Lynch syndrome, 22 with mutation-negative Lynch syndrome, 16 with familial adenomatous polyposis, two with constitutional mismatch repair deficiency, two with biallelic MUTYH mutations, and one with Li-Fraumeni syndrome. Patients without a hereditary syndrome more frequently presented with metastatic disease, whereas patients with a syndrome were more likely to present at earlier stages and to have a family history of cancer. Nevertheless, a substantial proportion of the hereditary syndromes (19%) were diagnosed in individuals with no family history of the disease. Conclusion We conclude that patients diagnosed with CRC at age 35 years or younger should receive genetic counseling regardless of their family history and phenotype.
Serum Immunoproteomics Combined With Pathological Reassessment of Surgical Specimens Identifies TCP-1ζ Autoantibody as a Potential Biomarker in Thyroid Neoplasia
Authors: Belousov Pavel V. , Bogolyubova Apollinariya V. , Kim Yan S. , Abrosimov Alexander Y. , Kopylov Arthur T. , Tvardovskiy Andrey A. , Lanshchakov Kirill V. , Sazykin Alexei Y. , Dvinskikh Nina Y. , Bobrovskaya Yana I. , Selivanova Lilia S. , Shilov Evgeniy S. , Schwartz Anton M. , Shebzukhov Yuriy V. , Severskaia Natalya V. , Vanushko Vladimir E. , Moshkovskii Sergei A. , Nedospasov Sergei A. , Kuprash Dmitry V. 
Published: July 2015

Context:Current methods of preoperative diagnostics frequently fail to discriminate between benign and malignant thyroid neoplasms. In encapsulated follicular-patterned tumors (EnFPT), this discrimination is challenging even using histopathological analysis. Autoantibody response against tumor-associated antigens is a well-documented phenomenon with prominent diagnostic potential; however, autoantigenicity of thyroid tumors remains poorly explored.Objectives:Objectives were exploration of tumor-associated antigen repertoire of thyroid tumors and identification of candidate autoantibody biomarkers capable of discrimination between benign and malignant thyroid neoplasms.Design, Setting, and Patients:Proteins isolated from FTC-133 cells were subjected to two-dimensional Western blotting using pooled serum samples of patients originally diagnosed with either papillary thyroid carcinoma (PTC) or EnFPT represented by apparently benign follicular thyroid adenomas, as well as healthy individuals. Immunoreactive proteins were identified using liquid chromatography-tandem mass-spectrometry. Pathological reassessment of EnFPT was performed applying nonconservative criteria for capsular invasion and significance of focal PTC nuclear changes (PTC-NCs). Recombinant T-complex protein 1 subunitζ (TCP-1ζ) was used to examine an expanded serum sample set of patients with various thyroid neoplasms (n = 89) for TCP-1ζ autoantibodies. All patients were included in tertiary referral centers.Results:A protein demonstrating a distinct pattern of EnFPT-specific seroreactivity was identified as TCP-1ζ protein. A subsequent search for clinicopathological correlates of TCP-1ζ seroreactivity revealed nonclassical capsular invasion or focal PTC-NC in all TCP-1ζ antibody-positive cases. Further studies in an expanded sample set confirmed the specificity of TCP-1ζ autoantibodies to malignant EnFPT.Conclusions:We identified TCP-1ζ autoantibodies as a potential biomarker for presurgical discrimination between benign and malignant encapsulated follicular-patterned thyroid tumors. Our results suggest the use of nonconservative morphological criteria for diagnosis of malignant EnFPT in biomarker identification studies and provide a peculiar example of uncovering the diagnostic potential of a candidate biomarker using incorporation of pathological reassessment in the pipeline of immunoproteomic research.
Governing Health Care Through Free Choice: Neoliberal Reforms in Denmark and the United States
Authors: Larsen Lars Thorup , Stone Deborah 
Published: July 2015

AbstractWe compare free choice reforms in Denmark and the United States to understand what ideas and political forces could generate such similar policy reforms in radically different political contexts. We analyze the two cases using our own interpretation of neoliberalism as having “two faces.” The first face seeks to expand private markets and shrink the public sector; the second face seeks to strengthen the public sector's capacity to govern through incentives and competition. First, we show why these two most-different cases offer a useful comparison to understand similar policy tools. Second, we develop our theoretical framework of the two faces of neoliberalism. Third, we examine Denmark's introduction of a free choice of hospitals in 2002, a policy that for the first time allowed some patients to receive care either in a public hospital outside their local area or in a private hospital. Fourth, we examine the introduction of free choice among private managed care plans into the US Medicare program in 1997. We show how policy makers in both countries used neoliberal reform as a mechanism to make their public health care sectors governable. Fifth, on the basis of our analysis, we draw five lessons about neoliberal policy reforms.
The Remarkable Staying Power of “Death Panels”
Authors: Frankford David M. 
Published: July 2015

Abstract
Sarah Palin's phrase “death panels” derailed proposed provisions of the Affordable Care Act (ACA) to pay physicians for end-of-life discussions with patients, a policy designed to make dying more humane, something all Americans desire. Even now, “death panels” has truth-value for approximately half of Americans and is used to paint ACA components as threatening to “pull the plug on Grandma.” How can this be? To some, the death panels claim is simply a lie, an improvised explosive device hurled against any ACA provision. To others, the phrase's power stems from the public's lack of a common vocabulary to discuss end-of-life care. “Death panels,” however, taps into many Americans' fear of government involvement, that government's purchasing end-of-life discussions as commodities necessitates accountability and cost control. Standardization and reduction of humanity follows, something Americans already experience routinely in their health care system. Expert jargon, compelling among experts themselves, doesn't evoke people's images of chats with Marcus Welby. The jargon is unintelligible, off-putting. When that jargon enters the nonjargonized world, it mixes with common fears, extant experience of dehumanization and reduction, and awareness that someone's plug is getting pulled all the time. “Death panels” cannot be dismissed as delusional, but neither can it help fulfill Americans' aspirations for a humane last voyage.
Crisis, convivencia multicultural y «efectos de barrio». El caso de dos barrios de Valencia
Authors: Torres Pérez Francisco , Moncusí Ferré Albert , Esteban Fernando Osvaldo 
Published: July 2015

La inserción urbana de los inmigrantes se desestabiliza y se pone a prueba con la crisis y las políticas aplicadas. Si bien en Valencia se mantiene una convivencia tranquila, la situación de los servicios públicos aumenta la competencia por recursos escasos entre vecinos de diferentes orígenes. Este texto presenta, en el marco de la ciudad de Valencia, un análisis comparativo de dos barrios receptores de inmigrantes que presentan fuertes contrastes. Por un lado, Russafa un barrio céntrico popular y en proceso de gentrification; por otro, Els Orriols, un barrio periférico obrero. Aún con muchos rasgos comunes, la intensidad del recelo hacia el inmigrante varía de un barrio a otro en función de su ambiente social y de su marco socio-urbano.
Atypical hemolytic-uremic syndrome in a patient with adenosine deaminase deficiency
Authors: Pham-Huy Anne , Kim Vy Hong-Diep , Nizalik Elizabeth , Weiler Gabrielle , Vethamuthu Jennifer , Grunebaum Eyal 
Published: July 2015

Inherited defects in the ubiquitous adenosine deaminase (ADA) enzyme disrupt the function of the immune system as well as many other organs and tissues. Some patients may also suffer from kidney damage. Here we report on an ADA-deficient patient who was treated with ADA replacement therapy from infancy and at 6 years of age developed acute kidney failure, thrombocytopenia, and severe anemia. A kidney biopsy demonstrated mesangiolysis and occlusion of kidney loops by erythrocytes and platelet aggregates, which is consistent with hemolytic-uremic syndrome (HUS). There was no evidence of exposure to Shiga toxins, nor were any complement abnormalities detected. The kidney function improved following hemodialysis. Our report demonstrates the increased susceptibility of ADA-deficient patients to develop HUS and expands the nonimmune abnormalities associated with ADA deficiency. This further emphasizes the vigilance required when caring for such patients. Statement of novelty: Here we provide the first detailed clinical and histological characterization of hemolytic-uremic syndrome developing in an ADA-deficient patient.
Eocene flora and trace fossils from the Hruby Regiel section in the Tatra Mountains (Poland): Taxonomic revision of the Wiktor Kuźniar fossil plant collection
Authors: Worobiec Grzegorz , Jach Renata , Machaniec Elżbieta , Uchman Alfred , Worobiec Elżbieta 
Published: July 2015

AbstractLatest Eocene plant macrofossils and trace fossils collected a century ago by Wiktor Kuźniar are revised and their stratigraphical and palaeoecological meaning is re-considered. They derive from marine limestones and marls cropping out on the northern slope of the Hruby Regiel mountain in the Western Tatra Mountains. Leaves belonging to the families Fagaceae and Lauraceae and fruits of the palm Nypa are recognized. The co-occurrence of the planktonic foraminifer taxa Chiloguembelina cf. gracillima and Globigerinatheca cf. index and fruits of Nypa suggests a latest Eocene age of the fossil flora. The plant assemblage is typical of paratropical or subtropical evergreen forests in a warm and humid subtropical climate, recent counterparts of which occur in southeast Asia. The presence of Nypa is characteristic of mangroves. The good state of preservation of the leaves suggests coastline proximity during sedimentation of the plant-bearing deposits.
The Influence of Study Specialization on the Moral Reasoning in University Students
Authors: Lajčiaková Petra 
Published: July 2015

Abstract
Significant importance has been attributed to moral judgment with regard to the moral and complex personal development of an individual. The study is focused on the moral thinking of university students, being interested in whether or not and to what extent does the university students´ specialization of study affect their moral judgment. A total of 180 students participated in the survey, half of them with technical specialization and the other half with humane disciplines. The Moral Judgment Test was used as a research tool for measuring their moral reasoning. The results showed a significant relation between the students´ moral reasoning and study specialization. Students with humane study specialization showed a much higher level of moral reasoning, referring to an input in the discussion on the method of developing university students´ moral competences.
Gender Differences in Attachment Styles Using Slovak Version of the Experiences in Close Relationships – Revised (ECR-R)
Authors: Rozvadský Gugová Gabriela , Heretik Anton 
Published: July 2015

Abstract
There is a vast amount of literature on similarities and differences of women and men experiencing (close) relationships and using different strategies for coping with daily stress and significant life events. Western folk psychology expects women to be generally more anxious and men to be more avoidant when solving close-relationship conflicts and experiences in long term relationships. We used the Experiences in Close Relationships - Revised (ECR-R) questionnaire that is based on the Attachment-style theory distinguishing four distinct attachment styles - secure, anxious/ambivalent, disoriented/disorganized and avoidant.
Barometer of Inclusive Education – Concept, Methodology and Preliminary Results in Selected European Countries
Authors: Schädler Johannes , Dorrance Carmen 
Published: July 2015

Abstract
This paper presents concept, methodology and preliminary results of a European research project on inclusive education of persons with disabilities. The project pathways to inclusion (p2i) is funded by the EU Commission and coordinated by the European umbrella organization European Association of Service Providers for Persons with Disabilities (EASPD). To get an overview on legal situations, practice and progression related to inclusive education a ‘barometer assessment’ instrument was developed and applied in 10 EU countries. The barometer criteria are deducted from Art. 24 of UN CRPD, the methodology follow the idea of the Open Method of Coordination and is explained as an information based rating. Selected results of the assessment are presented. The barometer instrument has proven as an effective tool for data analysis and assessment.
The Effect of Foreign Language Competences and Student Mobilities on Graduates’ Employability in the European Labour Market
Authors: Kozelová Dagmar , Frančáková Helena , Felixová Irena , Pietriková Miriam 
Published: July 2015

Abstract
Foreign language competences belong to the employers’ essential requirements set for workforce. The enhancement of acquired competences and the acquisition of new ones form a part of higher education. In the paper employability of the graduates of the Faculty of Biotechnology and Food Sciences in the Slovak University of Agriculture in Nitra on the European labour market has been analysed. The graduates completed their study in the years 2007-2011. A questionnaire was used to survey 300 graduates by the 30th June 2011, out of which 103 responded. The Faculty of Biotechnology and Food Sciences prepares professionals in the fields of biotechnology, food technology, applied biology, hygiene and food safety. Input data have been evaluated by the methods of analysis, synthesis and comparison. In relation to the mathematical-statistical methods used, the input data have been classified according to the qualitative and statistical characteristics and evaluated by the association tables and graphs. We have come to the conclusion that foreign language competences are actively used by 43% of the respondents in different sectors of national economy, and the dominant foreign language is English. Within half a year after graduation 74% of respondents who had taken part in student mobilities, and 48% of respondents who did not participate in them, found jobs on the labour market. The time of getting the first job is influenced not only by knowledge, working skills and other competencies but also by current job vacancies.
Technical Education Support in Pre-Primary Education by Interactive Teaching Systems
Authors: Brečka Peter , Bitterová Miriam 
Published: July 2015

Abstract
The paper deals with the possibility of interactive whiteboard (IWB) implementation to the technical education support in the frames of pre-primary education. It also presents some types of IWB, deals with problems associated with this issue and introduces teachers’ competencies needed for the work with them. The final part points out the results of the research realized in this field in the USA and in Slovakia.
Diagnostic and clinical significance of Crohn’s disease-specific pancreatic anti-GP2 and anti-CUZD1 antibodies
Authors: Pavlidis Polychronis , Komorowski Lars , Teegen Bianca , Liaskos Christos , Koutsoumpas Andreas L. , Smyk Daniel S. , Perricone Carlo , Mytilinaiou Maria G. , Stocker Winfried , Forbes Alastair , Bogdanos Dimitrios P. 
Published: July 2015

AbstractPancreatic autoantibodies (PAB) targeting GP2 and CUZD1 are Crohn’s disease (CrD)-markers. The clinical significance of anti-GP2 antibodies has been assessed, but that of anti-CUZD1 remains elusive. The aim of the study was to assess the clinical utility of anti-CUZD1/anti-GP2 by novel cell-based indirect immunofluorescence (IIF) assays in CrD.A total of 212 CrD and 249 UC patients followed up at a London IBD centre were investigated to simultaneously detect PABs, anti-GP2 and anti-CUZD1 by IIF using primate pancreatic tissue, and HEK293 over-expressing CUZD1 or GP2.Overall, 88 (41.5%) CrDs compared to 26 (10.4%) UCs (p<0.001) tested positive for IgA and/or IgG anti-GP2 and/or anti-CUZD1 antibodies, while ASCA were found in 67.5% CrDs versus 19.2% UCs (p<0.0001); ASCA and/or PAB (anti-GP2 or anti-CUZD1) were detected in 76% CrD versus 34% UC patients. IgG anti-GP2 antibodies were less prevalent in L2 phenotype (p=0.002) and more prevalent in patients with stricturing disease (p=0.0418), even when a higher cut-off (≥1000 RU) was used (p=0.0396). Also, anti-GP2 IgG positive CrD patients had younger age of disease onset. IgA and/or IgG ASCA and anti-GP2 IgG antibody positive CrDs had younger onset of disease (p<0.0001), were more likely to have both ileal and colonic disease (p<0.0001) and had more stricturing (p<0.0001) than seronegative patients. Clinical correlates were not found for anti-CUZD1 positivity.PAB testing increases ASCA’s serological sensitivity for CrD. Anti-GP2 detection, in isolation or in combination with ASCA, stratify CrD patients who phenotypically are characterised by a much younger onset of disease, extensive and stricturing behaviour.
Hyperuricemia as risk factor for coronary heart disease incidence and mortality in the general population: a systematic review and meta-analysis
Authors: Braga Federica , Pasqualetti Sara , Ferraro Simona , Panteghini Mauro 
Published: July 2015

AbstractPrevious meta-analyses reported no significant or weak association between hyperuricemia (HU) and coronary heart disease (CHD). We updated the literature search, systematically reviewing retrieved papers. The peer-reviewed literature published from 1965 to December 2014 was searched using Medline and Embase. We included prospective cohort studies involving adults (sample size ≥100) with no cardiovascular disease (CVD) and a follow-up of at least 1 year. Studies were excluded if they considered as outcome the CVD incidence/mortality without separately reporting data on CHD, did not adjusted for major confounders and if the 95% confidence interval (CI) for risk ratio (RR) was not available. Relative risk or hazard ratio estimates, with the corresponding CIs, were obtained. For CHD incidence 12 populations were included (457,915 subjects [53.7% males]). For CHD mortality seven populations were included (237,433 subjects [66.3% males]). The overall combined RR were 1.206 (CI 1.066–1.364, p=0.003) for CHD incidence and 1.209 (CI 1.003–1.457, p=0.047) for CHD mortality, respectively. Subgroup analysis showed a marginal (incidence) and not significant (mortality) association between HU and CHD in men, but an increased risk for CHD incidence and mortality in hyperuricemic women (RR 1.446, CI 1.323–1.581, p<0.0001, and RR 1.830, CI 1.066–3.139, p=0.028, respectively). The risk markedly increases for urate concentrations >7.0 mg/dL. HU appears to increase the risk of CHD events in the general population, mainly in adult women. This finding requires, however, further investigation.
Freeze-drying synthesis and characterisation of Na composites of ZnO, TiO2 and ZnTiO3 semiconductor oxides
Authors: Lokesh Budigi , Madhusudhana Rao Nasina , Kaleemulla Shaik , Sivakumar Amaravadi 
Published: July 2015

AbstractThe freeze-drying method of metal oxides synthesis has a number of advantages such as high homogeneity, varying porous structures, morphologies and uniform particle size distribution, etc. Because of these advantages, the binary metal oxides ZnO, TiO
Local Turbulent Energy Dissipation Rate in a Vessel Agitated by a Rushton Turbine
Authors: Šulc Radek , Pešava Vít , Ditl Pavel 
Published: July 2015

Abstract
The scaling of turbulence characteristics such as turbulent fluctuation velocity, turbulent kinetic energy and turbulent energy dissipation rate was investigated in a mechanically agitated vessel 300 mm in inner diameter stirred by a Rushton turbine at high Reynolds numbers in the range 50 000 < Re < 100 000. The hydrodynamics and flow field was measured using 2-D TR PIV. The convective velocity formulas proposed by Antonia et al. (1980) and Van Doorn (1981) were tested. The turbulent energy dissipation rate estimated independently in both radial and axial directions using the one-dimensional approach was not found to be the same in each direction. Using the proposed correction, the values in both directions were found to be close to each other. The relation ε/(N3·D2) ∞ const. was not conclusively confirmed.
A Mathematical Model of Membrane Gas Separation with Energy Transfer by Molecules of Gas Flowing in a Channel to Molecules Penetrating this Channel from the Adjacent Channel
Authors: Szwast Maciej , Szwast Zbigniew 
Published: July 2015

Abstract
The paper presents the mathematical modelling of selected isothermal separation processes of gaseous mixtures, taking place in plants using membranes, in particular nonporous polymer membranes. The modelling concerns membrane modules consisting of two channels - the feeding and the permeate channels. Different shapes of the channels cross-section were taken into account. Consideration was given to co-current and counter-current flows, for feeding and permeate streams, respectively, flowing together with the inert gas receiving permeate. In the proposed mathematical model it was considered that pressure of gas changes along the length of flow channels was the result of both - the drop of pressure connected with flow resistance, and energy transfer by molecules of gas flowing in a given channel to molecules which penetrate this channel from the adjacent channel. The literature on membrane technology takes into account only the drop of pressure connected with flow resistance. Consideration given to energy transfer by molecules of gas flowing in a given channel to molecules which penetrate this channel from the adjacent channel constitute the essential novelty in the current study. The paper also presents results of calculations obtained by means of a computer program which used equations of the derived model. Physicochemical data concerning separation of the CO2/CH4 mixture with He as the sweep gas and data concerning properties of the membrane made of PDMS were assumed for calculations.