bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective nutrition-inflammation markers for predicting early stoma-related complications in patients with colorectal cancer undergoing enterostomy
Authors: Yuan Jie , Jiang Fan , Fu Xiaochao , Hou Yun , Hu Yali , Yang Qishun , Liu Liyang , Wang Yufu , Sheng Wangwang , Cao Fuao , He Jinghu , Chen Guanglei , Peng Cheng , Jiang Wei 
Published: August 2024

BackgroundEnterostomy is important for radical resection of colorectal cancer (CRC). Nevertheless, the notable occurrence of complications linked to enterostomy results in a reduction in patients’ quality of life and impedes adjuvant therapy. This study sought to forecast early stoma-related complications (ESRCs) by leveraging easily accessible nutrition-inflammation markers in CRC patients.MethodsThis study involved 470 individuals with colorectal cancer who underwent intestinal ostomy at Changhai Hospital Affiliated with Naval Medical University as the internal cohort. Between January 2016 and December 2018, the patients were enrolled and randomly allocated into a primary training group and a secondary validation group, with a ratio of 2:1 being upheld. The research encompassed collecting data on each patient’s clinical and pathological status, along with preoperative laboratory results. Independent risk factors were identified through Lasso regression and multivariate analysis, leading to the development of clinical models represented by a nomogram. The model’s utility was assessed using decision curve analysis, calibration curve, and ROC curve. The final model was validated using an external validation set of 179 individuals from January 2015 to December 2021.ResultsAmong the internal cohort, stoma complications were observed in 93 cases. Multivariate regression analysis confirmed that age, stoma site, and elevated markers (Mon, NAR, and GLR) in conjunction with diminished markers (GLB and LMR) independently contributed to an increased risk of ESRCs. The clinical model was established based on these seven factors. The training, internal, and external validation groups exhibited ROC curve areas of 0.839, 0.812, and 0.793, respectively. The calibration curve showed good concordance among the forecasted model with real incidence of ostomy complications. The model displayed outstanding predictive capability and is deemed applicable in clinical settings, as evidenced by Decision Curve Analysis.ConclusionThis study identified nutrition-inflammation markers (GLB, NAR, and GLR) in combination with demographic data as crucial predictors for forecasting ESRCs in colorectal cancer patients. A novel prognostic model was formulated and validated utilizing these markers.
Naringin attenuates inflammatory injury to the bovine endometrium by regulating the endoplasmic reticulum stress–PI3K/AKT–autophagy axis
Authors: Lu Zihao , Peng Qingyang , Hu Ruiting , Wang Yan , Fan Kewei , Zhang Tao 
Published: August 2024

Background: Endometritis seriously affects maternal reproductive health and fertility. Natural compounds have the characteristics of high efficiency and low residue in disease treatment. We aimed to discover and reveal the pharmacological effects of naringin, which is widely present in food and plants, on endometritis.Methods: Based on network pharmacology, the potential targets and pathways of naringin’s actions on endometritis were predicted. Animal in vivo experiments were conducted to examine the inflammatory response of lipopolysaccharides (LPSs) in uterine tissue and the therapeutic effect of naringin. An in vitro primary bovine endometrial epithelial cell inflammation and drug treatment model was constructed. The production of reactive oxygen species (ROS) was measured using DCFH-DA, and the effect of naringin on LPS-induced endometritis was evaluated using HE staining, real-time quantitative PCR, Western blot, and immunofluorescence staining methods.Results: Naringin alleviated LPS-induced inflammatory injury and oxidative stress in the endometrium of mice and bovine endometrial epithelial cells (bEECs). Furthermore, in vitro studies were carried out to reveal the potential anti-inflammatory mechanisms of naringin based on network pharmacology. We found that naringin significantly inhibited LPS-stimulated endoplasmic reticulum stress (ERS)-related gene and protein expression, thus reducing the unfolded protein response (UPR). Furthermore, treatment of naringin attenuated the autophagic flux induced by ERS. In a further study, we observed that PI3K/AKT pathway inhibitors or ERS inducers partially reverse naringin’s inhibition of autophagy and cell apoptosis.Conclusion: It is demonstrated that naringin suppresses autophagy by directly inhibiting the ERS-PI3K/AKT axis and exerting anti-inflammatory and antioxidant effects in endometritis. These findings provide novel insights into the pathogenesis of endometritis, highlighting potential therapeutic targets of traditional herbs and compounds.
Gan-jiang-ling-zhu decoction improves steatohepatitis by regulating gut microbiota-mediated 12-tridecenoic acid inhibition
Authors: Xu Ruohui , Wu Jiaxuan , Pan Jiashu , Zhang Shengan , Yang Yunuo , Zhang Li , Zhou Wenjun , Wu Na , Hu Dan , Ji Guang , Dang Yanqi 
Published: August 2024

Introduction:Gan–jiang–ling–zhu (GJLZ) decoction is a classical traditional Chinese medicine prescription. Through invigorating yang, activating qi and dissipating dampness, GJLZ decoction is widely applied for the treatment of chronic digestive disease, including nonalcoholic fatty liver disease. However, efficacy and mechanism of GJLZ decoction behind nonalcoholic steatohepatitis (NASH) treatment remains unelucidated.Methods: NASH was induced in mice, followed by treatment with GJLZ decoction. Various methods including hematoxylin-eosin, oil red O staining, and triglyceride analysis were employed to evaluate the treatment effects of GJLZ decoction on NASH. Gut microbiota, metabolomics, cell viability assays, immunofluorescence and Western blotting were performed to unveil the mechanism behind GJLZ decoction.Results: GJLZ decoction treatment significantly improved hepatic steatosis in mice with NASH. It led to remodeling of gut flora and metabolite structures, including the 12-tridecenoic acid level. 12-Tridecenoic acid aggravated hepatic steatosis by promoting acetyl-coenzyme A carboxylase alpha (ACC) expression and inhibiting carnitine palmitoyltransferase 1A (CPT1A) expression. GJLZ decoction treatment reduced the 12-tridecenoic acid level, inhibited ACC activity and promoted CPT1A expression.Conclusion: Our results demonstrated that 12-tridecenoic acid aggravated hepatic steatosis by affecting the ACC–CPT1A axis and GJLZ decoction treatment effectively reduced the 12-tridecenoic acid level and improved steatosis.
Opposing objective and subjective wellbeing outcomes within an environmentally vulnerable delta: a case study of Volta Delta, Ghana
Authors: Cannings Laurence , Hutton Craig W. , Sorichetta Alessandro , Nilsen Kristine 
Published: August 2024

IntroductionDespite a growing interest in the measurement and conceptualization of wellbeing, the integration within sustainability research, and the understanding of how different wellbeing outcomes relate, is limited. Many studies focus on singular, often objectively measured, outcomes, without acknowledging the breadth of available measures. This approach can result in crucial subjective information, which can be explored to understand actors’ behaviors and responses, being omitted from research and policy. This study explores objective and subjective wellbeing outcomes, and how they relate, within an environmentally vulnerable context. Wellbeing and environmental services are intrinsically interlinked, therefore, appropriate policy solutions are required to address human needs and pressures on supporting ecosystems.MethodsThis paper uses binary logistic regression modelling, and qualitative participatory rural appraisal methods, to understand the environmental conditions, including climatic hazards and landscape characteristics, associated with households experiencing different objective/subjective wellbeing outcomes within Volta Delta, Ghana.ResultsThe mixed method approach highlights a differing relationship between inland agricultural areas impacted by drought and erosion, and coastal/riverine, peri-urban landscapes exposed to flooding and salinization. Agricultural areas associate with “poor but happy” outcomes, whereas peri-urban landscapes associate with being “non-poor but unhappy.” Drawing on existing literature, and both quantitative and qualitative results, these varying outcomes are hypothesized to be driven by differences in livelihood vulnerability, relative comparisons to others, responses to climatic hazards, and individualistic/collective wellbeing conceptualizations.DiscussionOur study concludes that environmental conditions influence objective and subjective wellbeing through different mechanisms. Sustainable development research should incorporate both objective and subjective measures when implementing and monitoring policy to more comprehensibly capture, and improve, wellbeing in environmentally vulnerable locations.
Meta-analysis of structural and functional brain abnormalities in early-onset schizophrenia
Authors: Wang Lu , Liu Ruishan , Liao Juan , Xiong Xin , Xia Linfeng , Wang Weiwei , Liu Junqi , Zhao Fulin , Zhuo Lihua , Li Hongwei 
Published: August 2024

BackgroundPrevious studies based on resting-state functional magnetic resonance imaging(rs-fMRI) and voxel-based morphometry (VBM) have demonstrated significant abnormalities in brain structure and resting-state functional brain activity in patients with early-onset schizophrenia (EOS), compared with healthy controls (HCs), and these alterations were closely related to the pathogenesis of EOS. However, previous studies suffer from the limitations of small sample sizes and high heterogeneity of results. Therefore, the present study aimed to effectively integrate previous studies to identify common and specific brain functional and structural abnormalities in patients with EOS.MethodsThe PubMed, Web of Science, Embase, Chinese National Knowledge Infrastructure (CNKI), and WanFang databases were systematically searched to identify publications on abnormalities in resting-state regional functional brain activity and gray matter volume (GMV) in patients with EOS. Then, we utilized the Seed-based d Mapping with Permutation of Subject Images (SDM-PSI) software to conduct a whole-brain voxel meta-analysis of VBM and rs-fMRI studies, respectively, and followed by multimodal overlapping on this basis to comprehensively identify brain structural and functional abnormalities in patients with EOS.ResultsA total of 27 original studies (28 datasets) were included in the present meta-analysis, including 12 studies (13 datasets) related to resting-state functional brain activity (496 EOS patients, 395 HCs) and 15 studies (15 datasets) related to GMV (458 EOS patients, 531 HCs). Overall, in the functional meta-analysis, patients with EOS showed significantly increased resting-state functional brain activity in the left middle frontal gyrus (extending to the triangular part of the left inferior frontal gyrus) and the right caudate nucleus. On the other hand, in the structural meta-analysis, patients with EOS showed significantly decreased GMV in the right superior temporal gyrus (extending to the right rolandic operculum), the right middle temporal gyrus, and the temporal pole (superior temporal gyrus).ConclusionThis meta-analysis revealed that some regions in the EOS exhibited significant structural or functional abnormalities, such as the temporal gyri, prefrontal cortex, and striatum. These findings may help deepen our understanding of the underlying pathophysiological mechanisms of EOS and provide potential biomarkers for the diagnosis or treatment of EOS.
A motivational training program for secondary physical education teachers based on the circumplex model: a study protocol of a randomised controlled trial
Authors: García-Cazorla Javier , Sevil-Serrano Javier , García-González Luis , Abós Ángel 
Published: August 2024

In most self-determination theory (SDT) research, improving (de)motivating teaching styles provides numerous benefits for students and teachers, although there is less evidence of the latter. Although the recent circumplex model provides a fine-grained picture of the different (de)motivating teaching styles (i.e., autonomy support, structure, control, and chaos) that physical education (PE) teachers can use in their lessons, no previous motivational training programs have been based on this model. Moreover, all SDT-training programs have been implemented through different group sessions, but individual sessions have not been delivered. This study outlines the protocol of a motivational training program, derived from the circumplex model, designed to enhance motivating teaching styles (and prevent or decrease demotivating teaching styles) among PE teachers. Consequently, this program seeks to improve motivational variables and influence (mal)adaptive outcomes in both teachers and students. A randomised controlled trial design with a mixed-method approach. At least 16 secondary PE teachers will be assigned to either an experimental group or a control group, together with some of their students. The training program comprises four face-to-face group sessions and two follow-up sessions (one individual and one group session). PE teachers will learn how to support autonomy and provide structure, as well as to be less controlling and chaotic towards students. Over approximately five months, teachers will implement these motivational strategies during their PE classes. Different (de)motivating teaching styles, motivational variables, and (mal)adaptive outcomes will be assessed in both PE teachers and their students at three distinct points: before the training program (T1), during the intervention (T2), and at the end of the intervention (T3). Additionally, two discussion groups involving all experimental PE teachers will be held (one following the training program and another at the end of the intervention). The results from this study could be useful for developing motivational training programs for in-service PE teachers.Clinical trial registration: ClinicalTrials.gov, identifier [NTC06479369].
Type III Secretion Effectors of Xanthomonas oryzae pv. oryzicola: The Arsenal to Attack Equivalent Rice Defense for Invasion
Authors: Tan Nawei , Huang Yechao , Miao Weiguo , Zhang Qingxia , Wu Tao 
Published: August 2024

Rice–Xanthomonas oryzae pv. oryzicola (Xoc) is one of the commonly used rice models of host–pathogen interactions. Xoc causes bacterial leaf streak (BLS) and has quarantine status. As a Gram-negative pathogen, Xoc usually employs type III secretion effectors (T3SEs), including transcription activator-like effectors (TALEs) and non-TALEs, to interfere with the innate immunity of rice. However, few major resistance genes corresponding to Xoc are found in rice cultivations; only Rxo1-AvrRxo1 and Xo1-TALEs interactions have been discovered in rice–Xoc. In this review, we focus on the role of the T3S system (T3SS) in Xoc virulence and consider the reported non-TALEs, including AvrRxo1, AvrBs2, XopN, XopC2, XopAP, and XopAK, as well as TALEs including Tal2g/Tal5d, Tal2h, Tal2a, Tal7, Tal10a, TalI, Tal2b, and Tal2c. Interestingly, AvrRxo1, XopC2, and XopAP disturb stomatal opening to promote infection through targeting diverse signaling pathways in rice. Otherwise, Tal2b and Tal2c, respectively, activate two rice salicylic acid (SA) hydroxylation genes to redundantly suppress the SA-mediated basal defense, and TalI, which has unknown targets, suppresses the SA signaling pathway in rice. In addition, other Xoc virulence factors are discussed. In conclusion, several T3SEs from Xoc interfere with similar defense pathways in rice to achieve invasion, providing an outlook for the control of this disease through manipulating the conserved pathways.
KAJIAN PENGGUNAAN MEJA DAN KURSI ADJUSTABLE SMK NEGERI 3 MEDAN
Authors: Bayu Bayu Herman Syah , Zaharuddin  , Utama Denny Walady 
Published: August 2024

The success of children in learning is strongly influenced by several factors such as the teacher, tools or facilities, facilities and infrastructure, the surrounding environment. One of the educational facilities and infrastructure that supports learning that is not given enough attention is the study desks and chairs for students in class. Tables and chairs are one of the most closely related factors in improving the quality of learning. If the tables and chairs are not ergonomic, during the learning process students will easily feel tired and not focus when learning takes place.This study aims to determine the factors that influence musculoskeletal complaints in students and find out whether adjustable tables and chairs can reduce these complaints. Completion in this study using anthropometric methods.The conclusion of this study is that there are several factors that cause musculoskeletal disorders, namely non-ergonomic seating, high chairs, high tables, inappropriate sitting positions, and sitting too bent. Where the results of the study stated that each table and chair size must be in accordance with its users, so that it can be used comfortably.

Keywords: adjustable tables and chairs, musculoskeletal, anthropometry.
PKM Pelatihan Pembuatan Media Pembelajaran bagi Guru TK/PAUD Bunga Asya Makassar
Authors: Side Syafruddin , Sidjara Sahlan , Pratama Muhammad Isbar , Andi Pandjajangi Andi Muhammad Ridho Sainon , Utari Astri 
Published: August 2024

Kegiatan Program Kemitraan Masyarakat (PKM) dilaksanakan di desa Mallongi-longi Kecamatan Lanrisang Kabupaten Pinrang. Tujuan kegiatan ini adalah untuk: a) mitra dapat membuat dan menggunakan media pembelajaran dari barang bekas berdasarkan hasil dari pembelajaran media canva berbasis teknologi sebagai media bagi guru TK/PAUD Bunga Asya kota Makassar, b) kelompok guru TK/PAUD Bunga Asya tentang media pembelajaran matematika menggunakan canva kemudian menggunakan barang bekas, c) mitra dapat mendemonstrasi pengajaran dengan media pembelajaran matematika dari barang bekas bagi anak didik dalam proses belajar mengajar dikelas. Permasalahan mitra adalah: a) Kurang maksimalnya penggunaan media pembelajaran dari barang bekas sebagai media bagi guru TK/PAUD Bunga Asya di Kecamatan Tamalanrea Kota Makassar, b) Rendahnya pengetahuan guru-guru TK/PAUD Bunga Asya di kecamatan Tamalanrea Kota Makassar tentang media pembelajaran matematika dari barang bekas, c) Rendahnya keterampilan dan kemampuan guru TK/PAUD di kecamatan Tamalanrea Makassar dalam mengajar berbatuan media dari barang bekas sebagai media. Metode yang digunakan adalah pelatihan, diskusi dan penyuluhan secara kolaborasi antara pelaksana dengan mitra. Metode ini dilaksanakan kepada kelompok mitra aktif sebanyak 12 orang dari 12 orang selama 2 hari dan selanjutnya evaluasi dan monitoring dilakukan secara berkala selama 3 bulan. Hasil kegiatan ini adalah: meningkatnya kemampuan dan pengetahuan seluruh anggota mitra aktif tentang media pembelajaran dari barang bekas berdasarkan hasil dari pembelajaran media canva berbasis teknologi sebagai media bagi guru TK/PAUD Bunga Asya kota Makassar.
Evaluasi Program Integrated Farming System Berbasis Jagung Kabupaten Karawang
Authors: Irwansyah Wahyu , Purnomo Sulistyo Sidik , Wulandari Yeni Sari 
Published: August 2024

Program pertanian terpadu merupakan pengembangan sistem usahatani yang memadukan antara kegiatan peternakan dan pertanian secara terintegrasi. Program integrated farming system berbasis jagung di Kabupaten Karawang dibentuk untuk meningkatkan manfaat bagi masyarakat dan lingkungan. Untuk melihat jalannya program dalam mencapai tujuan, diperlukan evaluasi pelaksanaan serta hasilnya.Tujuan penelitian ini adalah untuk mengindentifikasi dan menganalisis pelaksanaan dan hasil program pada masing-masing kelompok tani penerima bantuan di Kabupaten Karawang. Metode penelitian yang digunakan adalah metode kualitatif dan kuantitatif yang disajikan dalam bentuk deskriptif. Narasumber penelitian adalah peserta kelompok tani penerima bantuan program integrated farming system berbasis jagung Kabupaten Karawang. Teknik pengumpulan data dilakukan dengan observasi, wawancara, dan dokumentasi. Teknik analisis data secara kualitatif model Miles and Huberman (1984) flow model, analisis data kuantitaif meliputi perhitungan penerimaan total biaya, dan pendapatan. Hasil penelitian menunjukkan bahwa terdapat kendala yang dihadapi oleh kelompok tani seperti serangan penyakit pada itik, itik tidak berproduksi secara maksimal, serangan hama ulat pada tanaman jagung, keterbatasan anggaran, pelaksanaan penanaman jagung tidak berjalan sepenuhnya, menghambat tercapainya tujuan program hingga program terhenti dan tidak berlanjut. Secara ekonomi program tidak menciptakan peningkatkan pendapatan. Dampak terhadap lingkungan berupa pemanfaatan limbah ternak. Secara sosial dapat memberikan pengalaman baru bagi petani dalam pengelolaan ternak secara intensif.
Penyerapan Tenaga Kerja Pada Sektor Usaha Kecil Dan Menengah
Authors: Putra Romualdus Turu 
Published: August 2024

“Penyerapan Tenaga Kerja Pada Sektor Usaha Kecil Dan Menengah Di Distrik Sota Kabupaten Merauke’’ Penelitian ini bertujuan untuk mengetahui keseluruhan data Penyerapan Tenaga Kerja (PTK) di Kabupaten Merauke. Adapun sampel dalam penelitian ini adalah data Penyerapan Tenaga Kerja (PTK) Tahun 2009– 2020. Penelitian ini menggunakan teknik analisis data korelasi merupakan bagian dari penerapan statistika yang digunakan untuk mengetahui keeratan atau derajat kekuatan hubungan linier dari suatu variabel dengan variabel lain. Keeratan suatu hubungan ini dinyatakan dengan besaran nilai korelasi (r) yang nilainya berada dalam rentang -1 sampai dengan 1. Jika nilai yang diperoleh semakin dekat ke angka 1 itu berarti hubungan semakin kuat dan arah hubungan tersebut adalah searah, tanda positif menunjukkan arah yang sama atau searah. Hasil Penelitian Distrik Sota merupakan bagian dari salah satu dari 20 Distrik di Kabupaten Merauke, dengan luas wilayah +2.600,54 Km2. Batas Wilayah Distrik Secara Administrasi; Sebelah timur Papua New Guinea, Sebelah barat Distrik Jagebob & Tanah Merah, Sebelah utara Distrik Elikobel, Sebelah selatan Distrik Merauke.
Kata kunci : Jumlah Unit Usaha Ukm, Nilai Investasi Ukm,Upah Minimum
Ukm, Penyerapan Tenaga Kerja (PTK).
Pengaruh Industri Kecil dan Menengah terhadap Pertumbuhan Ekonomi
Authors: Siman Sebestina 
Published: August 2024

Pengaruh Industri Kecil dan Menengah terhadap Pertumbuhan Ekonomi di Kabupaten Merauke. Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh jumlah unit usaha dan tenaga kerja terhadap pertumbuhan ekonomi di Kabupaten Merauke. Variabel yang digunakan adalah jumlah unit usaha dan tenaga kerja terhadap pertumbuhan ekonomi. Metode analisis regresi linear berganda yang diolah dalam aplikasi SPSS Versi 23. Jenis data yang digunakan adalah data kuantitatif selama 10 tahun yaitu dari tahu 2012-2021. Sumber data pada penelitian ini yaitu data sekunder yang diperoleh secara peneliti dari Dinas Perindustrian, dan Perdagangan, Usaha Kecil Menengah dan Koperasi serta Badan Pusat Statistik (BPS) di Kabupaten Merauke. Hasil penelitian ini menunjukkan bahwa secara parsial variabel jumlah unit usaha berpengaruh positif dan signifikan terhadap pertumbuhan ekonomi di Kabupaten Merauke dengan nilai koefisien sebesar 1,849 dan nilai signifikansi 0,000 yang diperoleh lebih kecil dari dari 0,05. Kemudian variabel jumlah tenaga kerja berpengaruh negatif dan signifikan terhadap pertumbuhan ekonomi di Kabupaten Merauke dengan nilai koefisien sebesar -.828 dan nilai signifikansi 0,018 yang diperoleh lebih kecil dari dari 0,05. Sedangkan secara simultan variabel jumlah unit usaha dan tenaga kerja mempunyai pengaruh terhadap pertumbuhan ekonomi di Kabupaten Merauke.
Kata Kunci: Industri Kecil dan Menengah, tenaga kerja, pertumbuhan ekonomi