bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transforming Growth Factor‐β Inhibition and Endothelin Receptor Blockade in Rats with Monocrotaline‐Induced Pulmonary Hypertension
Authors: Megalou Aikaterini J. , Glava Chryssoula , Vilaeti Agapi D. , Oikonomidis Dimitrios L. , Baltogiannis Giannis G. , Papalois Apostolos , Vlahos Antonios P. , Kolettis Theofilos M. 
Published: December 2012

Transforming growth factor‐β (TGF‐β) inhibition is an investigational therapy for pulmonary arterial hypertension with promising results in experimental studies. The present work compared this approach with endothelin‐receptor blockade and evaluated the effects of combined administration. Pulmonary arterial hypertension was induced by single monocrotaline injection (60 mg/kg) in 75 Wistar rats and 15 rats served as controls. Intervention groups consisted of treatment with an antibody against TGF‐β‐ligand, bosentan, both or none, initiated four weeks after monocrotaline injection. Right ventricular systolic pressure, pulmonary vascular remodeling, and exercise tolerance were evaluated eight weeks after monocrotaline injection. Either treatment, alone or in combination, lowered mortality. Comparable efficacy was found in the three treatment groups in terms of right ventricular systolic pressure (~45% decrease) and hypertrophy (~30% decrease), as well as exercise capacity. The three treatment groups equally ameliorated pulmonary vascular remodeling, evidenced by decreased vessel‐wall thickness (in vessels 50–200 μm) and a smaller number of pre‐∗∗∗capillary arterioles (< 50 μm) with a muscularized media. Treatment either with an antibody against TGF‐β or with endothelin receptor blockade are equally effective in experimental pulmonary hypertension. Their combination provides no added benefit, indicating common mechanisms of action.
To Study the Utilization Pattern of Nasal Decongestants and their Effects on Heart Rate and Blood Pressure
Authors: Chopra Asmita 
Published: December 2012

ABSTRACT

Background
Nasal decongestants (NDs) are frequently prescribed over the counter (OTC) drugs for cough and cold. These are sympathomimetic drugs, which act through α1 and β1 adrenoceptors to cause vasoconstriction and positive inotropic, chronotropic and dromotropic effect on the heart. This study was conducted to assess the pattern of utilization of the NDs and their effect on heart rate (HR) and blood pressure (BP). Patients were observed for any other adverse drug reactions (ADRs).

Materials and methods
Randomly 100 prescriptions containing NDs were collected from the otorhinolaryngology OPD and were analyzed. All these patients were examined for HR and BP on day 0, 3 and 7 of administration of NDs. Any ADRs were also recorded.

Results
Mean ND used per patient was 1.08/patient. Commonly prescribed NDs were phenylephrine (72.2%), pseudoephedrine (12.9%), phenylpropanolamine (6.5%), xylometazoline (6.5%) and oxymetazoline (1.8%). Eight patients received two NDs orally and/or topically. There was a significant rise in heart rate on day 7 (p < 0.05). However, the rise in BP was insignificant both on days 3 and 7. Frequently observed ADR's included headache, palpitations and dizziness.

Discussion
Some NDs are known to raise the HR and BP. Baseline BP monitoring should be done to avoid any further rise in BP and HR. being an OTC drug there are more chances of adverse effects of these NDs. It is suggested that NDs should be prescription only drugs, till adequate evidence is available regarding their safety.

How to cite this article
Rehan HS, Chopra A, Kumar S. To Study the Utilization Pattern of Nasal Decongestants and their Effects on Heart Rate and Blood Pressure. Clin Rhinol An Int J 2012;5(3):91-94.
Sinonasal Teratocarcinosarcoma: A Rare Clinical Entity managed by Medial Maxillectomy and Adjuvant Chemoradiation
Authors: Gupta Sumit , Naik Sudhir , LNU Nanjundappa , Halkud Rajshekar , LNU Srihariprasad , Sidappa K , Rao Clementina Rama 
Published: December 2012

ABSTRACT

Background/objectives
Sinonasal teratocarcinosarcoma is a rare aggressive malignant tumor arising in the sinonasal tract and a malignant neoplasm of uncertain histogenesis. As the tumor contains various components of teratoma, sarcoma and carcinoma arising from cells of embryonic origin majority of the patients suffer locoregional failure.

Case report
A 35-year-old patient reported with history of left-sided nasal obstruction since 2 months. A polypoid mass was seen in the left nasal cavity and a clinical diagnosis of infected antrochoanal polyp endoscopic sinus surgery was done. Histopathology with immunohistochemistry confirmation yielded the report as teratocarcinosarcoma.

Intervention
Medial maxillectomy with a Moure's incision was done with adjuvant intensity modulated radiotherapy and chemotherapy. Histopathological analysis of the specimen confirmed the earlier pathology.

Conclusion
Sinonasal teratocarcinosarcoma has a proven poor prognosis with locoregional recurrence. The disease free survival rate is nearly 28% and overall survival rate is of 46%. Optimal resection margins are to be defined and multimodality treatment in the form of postoperative radiotherapy and chemotherapy are to be standardized.

How to cite this article
Naik SM, Nanjundappa, Halkud R, Srihariprasad, Sidappa K, Gupta S, Rao CR. Sinonasal Teratocarcinosarcoma: A Rare Clinical Entity managed by Medial Maxillectomy and Adjuvant Chemoradiation. Clin Rhinol An Int J 2012;5(3):118-122.
Nasal Dermoid Sinus Cyst expanding into Frontal Sinus: A Rare Presentation
Authors: Gupta Ashok , LNU Rijuneeta , Budhiraja Grace , Francis Abhilash Alex 
Published: December 2012

ABSTRACT
Nasal dermoid sinus cysts are uncommon congenital anomalies that require interventions only when they present as complications. They frequently present in childhood as midline nasal masses requiring excision. They may present with intracranial as well as intraorbital extensions, making it necessary to subject the patient for proper radiological diagnosis preoperatively. Here, we present a rare case report of 28-year-old male patient who presented at our tertiary health care center with nasal dermoid cyst expanding into the frontal sinus causing proptosis and blurring of vision. The cyst was excised by combined approach, i.e. external nasal dermoid sinus tract excision and endoscopic nasofrontal sinusotomy for complete removal. The embryology, clinical history, diagnosis and surgical management are discussed.

How to cite this article
Gupta R, Gupta A, Budhiraja G, Francis AA. Nasal Dermoid Sinus Cyst expanding into Frontal Sinus: A Rare Presentation. Clin Rhinol An Int J 2012;5(3):123-126.
O balanced scorecard como ferramenta de gestão estratégica em uma universidade federal
Authors: Richartz Fernando , Krüger Letícia Meurer , Borgert Altair , Petri Sergio Murilo 
Published: December 2012

O objetivo deste trabalho é estruturar um Balanced Scorecardpara o Departamento de Ciências Contábeis da Universidade Federal de Santa Catarina, cuja finalidade é alinhar uma área de negócio (CCN) com as estratégias definidas pela corporação (UFSC). Para a elaboração do BSC parte-se das informações contidas no planejamento estratégico do departamento, desenvolvido em 2008, para o período 2009/2020. O mapa estratégico contempla quatro perspectivas, sete subáreas, vinte e seis objetivos, bem como as relações entre eles. A base do mapa são as pessoas, que por meio de processos se relacionam com os clientes e com a sociedade. Posteriormente, com base nos objetivos definidos, elaborou-se o painel balanceado. Nele, cada objetivo possui um indicador de controle, um valor de referência, uma meta (para ser atingida até 2020) e ações ou iniciativas a serem tomadas para atingir os objetivos. No entanto, por serem informações estratégicas, são apresentadas de forma mais detalhada apenas as informações da perspectiva “pessoas”. Os resultados desta perspectiva são: i) Para o indicador % de professores com grupos de estudos registrados no CNPQ tem-se como referência 25% e estima-se como meta o percentual de 50%; ii) para o % de doutores com Pós-Doc concluído ou em desenvolvimento tem-se como referência 20% e meta 50%; iii) em relação ao % de docentes que cursaram ao menos um curso por ano dos oferecidos pelo Profor tem-se, atualmente, 22% e como meta 80%; iv) para o número de programas Universidade/Professor/Empresa utiliza-se a referência de 2 e meta de pelo menos 5; v) por fim, para o % de professores pertencentes ao CFC, CPC, Ibracon, CRCs tem-se 15% e pretende-se atingir 30% até 2020.
Análise da sustentabilidade ambiental de uma instituição de ensino segundo o Sistema Contábil Gerencial Ambiental – Geração 2
Authors: Keunecke Gabriella Rossi , Uhlmann Vivian Osmari , Pfitscher Elisete Dahmer 
Published: December 2012

Este estudo teve como objetivo analisar o grau de sustentabilidade de uma instituição de ensino com base no método SICOGEA (Sistema Contábil Gerencial Ambiental) – Geração 2 e propor medidas para minimizar os danos causados pelo processo de prestação de serviços da instituição de ensino ao meio ambiente e à sociedade. No processo de coleta dos dados, utilizou-se uma lista de verificação composta por 153 questões dispostas em grupos-chave e subgrupos, tendo sido respondida pela contadora da instituição pesquisada. A instituição de ensino apresentou uma sustentabilidade ambiental global de 41%, que é considerada fraca pelo método adotado neste estudo. O grupo-chave Marketing obteve o melhor índice de sustentabilidade ambiental, com 73,66%. Em contrapartida, o grupo-chave Contabilidade e Finanças apresentou o menor índice de sustentabilidade ambiental, com apenas 17,72%, o que ensejou a elaboração do plano resumido de gestão ambiental. Observou-se pouca preocupação e conscientização com as questões sociais e ambientais, não tendo sido observada uma política de qualidade ambiental por parte da instituição. Além disso, não foi constatada na instituição a economia de insumos e/ou matérias-primas, como também não foram percebidos mecanismos de controle da conformidade das atividades com os regulamentos ambientais, tampouco o registro de imobilizados ambientais.
Diagnóstico e alternativas de contenção da evasão no curso de administração em uma universidade pública no sul do brasil
Authors: Mello Simone Portella Teixeira de , Santos Elaine Garcia dos 
Published: December 2012

Este estudo é parte de projeto de pesquisa, desenvolvido em uma universidade pública no sul do Brasil e tem como objetivo revelar os fatores que contribuem para evasão no curso superior de Administração no período de 2009 a 2011. Conforme ampliação das vagas no ensino superior público brasileiro, a evasão também tem aumentado, o que infere um problema a ser tratado com atenção pela gestão da educação superior. O diagnóstico é etapa preliminar às ações futuras para minimizar a evasão das IES. Faz-se revisão teórica sobre o tema, relacionando causas informadas com a literatura. Revelam-se alternativas no âmbito do curso e de políticas institucionais. A pesquisa é de essência qualitativa e utiliza entrevista semi-estruturada com questões abertas e fechadas, desenvolvidas via email e telefone. Os resultados revelam: homens evadem mais que mulheres, a idade predominante está entre 21 e 29 anos. As justificativas predominantes dos evadidos, para a evasão são: carga horária de trabalho excessiva, incompatibilidade de horário entre trabalho e curso e expectativas diferentes com relação ao curso. Controle on line da freqüência do aluno, melhor relação aluno-curso-docente, bolsas de permanência e ações prospectivas como divulgar o perfil do egresso-administrador no ensino médio, podem conter a evasão.
Material didático em educação a distância: fragmentação da docência ou autoria
Authors: Borges Eliane Medeiros , Jesus Diovana Paula de , Fonseca Danilo Oliveira 
Published: December 2012

O artigo apresentado visa traçar uma compreensão acerca da produção de materiais didáticos para cursos de Educação a Distância (EaD). A partir da percepção de que o material didático é parte importante da maioria dos projetos da modalidade, procuramos tomar conhecimento da concepção de educação subjacente a esta produção. Busca-se também investigar modelos que tendem a prevalecer nas práticas contemporâneas de EaD no país. A investigação, ainda em curso, aborda duas possibilidades de construção de material didático para EaD: a primeira, que apregoa uma feitura industrial e segmentada, com ênfase na transmissão de conhecimento e informação; e a segunda possibilidade, supondo uma realização mais artesanal e dinâmica, tendo como base a autoria e autonomia do professor nos materiais apresentados. O estudo se concentrou em dois cursos específicos de EaD da UFJF, pertencentes ao modelo da Universidade Aberta do Brasil (UAB) com o intuito de comparar dois sistemas de curso em pleno funcionamento. Foram aplicados questionários aos professores de ambos os cursos, e entrevistas com os professores do curso que tinha material didático pré-produzido. Os resultados apontam para o esforço de autoria do professor, mesmo quando impelido à utilização de material didático elaborado sem a sua participação.
El proceso de acreditación institucional del PE de pedagogía por EL CEPPE
Authors: Blanco Areli Pérez , Barraza Brenda González 
Published: December 2012

El presente trabajo trata de la experiencia que tuvieron tanto alumnos como personal docente de la acreditación institucional CEPPE en la Facultad de Pedagogía Región Poza Rica Tuxpan, partiremos desde la fundación de la Facultad de Pedagogía, enfatizando y describiendo todo el proceso de acreditación CEPPE.La visión que se tuvo acerca de la Evaluación que se llevó dentro de la Facultad de Pedagogía particularmente con el Proceso de Acreditación, es que la evaluación es la mejor herramienta para conocer la realidad de una Institución, de un Programa Académico. Esta investigación estuvo sustentada por el Paradigma Cualitativo. Nuestra metodología se inclina a la recolección de datos de manera verbal o escrita y comprender las conductas de los actores de estudio tal y como se muestra en la realidad. En esta investigación Cualitativa, pretendemos describir el Proceso de Acreditación en la Facultad de Pedagogía, es decir, saber cómo piensan los sujetos implicados en esta investigación.
Nittsū’s Company History as a Guide to the Early Modern Origins of Japan’s Modern Communications
Authors: Andrews Charles 
Published: December 2012

Historians of the future will no doubt focus on the transformative role of Internet-based communications as they have changed human interaction in the late twentieth and early twenty-first centuries. The introduction of modern postal services in Japan and elsewhere in the nineteenth century produced effects no less profound: citizens were connected to each other and their governments by reliable and relatively speedy delivery of letters, newspapers, and parcels. Japan’s postal system was a great success, but the communications practices of the Japanese prior to the establishment of the post played an important role in that success. Courier services—the so-called hikyakuya—of the early modern period survived and ultimately became today’s Nippon Tsūun (Nittsū), and global logistical corporation. This article surveys the development of early modern Japanese communications, demonstrating the indispensible role that Nittsū’s company history plays in understanding that development.
The Great Kanto Earthquake as Seen in Shashi
Authors: Kadokura Yuriko 
Published: December 2012

Abstract: Since the Meiji period, companies throughout Japan have published shashi, or company histories. Shashi contain not only the company’s history but also numerous descriptions of the contemporary social environment including the effects of disasters and war. Shashi show how various companies, and Japanese society as a whole, dealt with the difficulties they faced, how they chose their path to recovery, and how these actions were recorded to be shared with future generations. Following the Great East Japan Earthquake in March 2011, we added the category “Disaster and Revival as Seen in Shashi” to the blog of the Resource Center for the History of Entrepreneurship. The category allows users to access information from the “Shashi Index Database Project,” which is currently under construction, and introduces shashi articles on “Disaster and Revival,” particularly the Great Kanto Earthquake. 和文抄録： 明治以降日本各地の会社が出版した「社史」の中には、会社の沿革や事業だけではなく、災害や戦災などを含む当時の社会情勢に関する記述が数多く見られる。その内容からはそれぞれの会社や日本の社会が降りかかる困難に対峙してどのように対処したか、復興の道筋をどのようにつけたか、そしてそれをどのように記録し次代に伝えようとしたか、といったことを読みとることができる。 2011年3月11日の東日本大震災に際し実業史研究情報センターでは、センター・ブログに「社史に見る災害と復興」というカテゴリーを新設した。そこでは現在構築中の「社史索引データベースプロジェクト」の蓄積データを検索し、「災害と復興」特に「関東大震災」に関する記事を含む社史について紹介している。
Significance of Chronic Tachycardia in Systemic Lupus Erythematosus
Authors: Utset Tammy O. , Ward Adam B. , Thompson Toi L. , Green Stephanie L. 
Published: December 2012

AbstractObjectiveA significant subset of systemic lupus erythematosus (SLE) patients exhibit chronic tachycardia (CT) of unknown significance. We postulated that CT is a marker of lupus activity and severity.MethodsA cross‐sectional database at the University of Chicago recorded disease activity, damage, disease manifestations, pain, anxiety, and physical function (PF). CT was defined as a heart rate of ≥95 beats per minute in at least 3 out of 4 sequential visits. Demographic, disease‐specific, and self‐reported symptoms were compared between groups with and without tachycardia.ResultsOf the 243 subjects analyzed, 14.8% had CT. On univariate analysis, CT was associated with younger age at the time of enrollment (P = 0.004), number of hospitalizations adjusted for years of SLE (P = 0.001), current prednisone dose (P < 0.0001), history of serositis (P = 0.03), anxiety score (P = 0.004), and poor PF (P = 0.0017). All domains of the Short Form 36 (SF‐36) health survey correlated strongly with CT, but on multivariate regression this correlation appeared to be driven by poor PF. On multivariate regression, the Systemic Lupus Erythematosus Disease Activity Index score (P = 0.03), younger age (P = 0.04), and poor PF by the SF‐36 domain (P = 0.006) were independently correlated with CT, and anxiety trait and hemoglobin both trended closely to significant association (P = 0.08 for both).ConclusionCT is prevalent in SLE and is a clinically relevant physical finding. It implies greater lupus activity and physical frailty. Univariate association with serositis raises the possibility of subclinical serositis or pancarditis. Further study to elucidate the cardiopulmonary status of SLE patients with unexplained CT is planned.
Influence of Family Environment on Long‐Term Psychosocial Functioning of Adolescents With Juvenile Fibromyalgia
Authors: Sil Soumitri , Lynch‐Jordan Anne , Ting Tracy V. , Peugh James , Noll Jennie , Kashikar‐Zuck Susmita 
Published: December 2012

ObjectiveLittle is known about the impact of family environment on the long‐term adjustment of patients with juvenile‐onset fibromyalgia (JFM). Our objective was to evaluate whether family environment in early adolescence predicted later physical functioning and depressive symptoms of adolescents with JFM as they transitioned to early adulthood in the context of a controlled long‐term followup study.MethodsParticipants consisted of 39 youth (mean age 18.7 years) with JFM and 38 healthy matched controls who completed web‐based surveys about their health status (Short Form 36 health survey) and depressive symptoms (Beck Depression Inventory II) ∼4 years after a home‐based, in‐person assessment of child and family functioning. During the initial assessment, parents of the participants (94% mothers) completed the Family Environment Scale and adolescents (mean age 14.8 years) completed self‐report questionnaires about pain (visual analog scale) and depressive symptoms (Children's Depression Inventory).ResultsThe results indicated that family environment during early adolescence significantly predicted greater depressive symptoms in early adulthood for both the JFM group and the healthy controls. In particular, a controlling family environment (use of rules to control the family and allowing little independence) during early adolescence was the driving factor in predicting poorer long‐term emotional functioning for patients with JFM. Family environment did not significantly predict longer‐term physical impairment for either group.ConclusionAdolescents with JFM from controlling family environments are at an increased risk for poorer emotional functioning in early adulthood. Behavioral and family interventions should foster independent coping among adolescents with JFM and greater parenting flexibility to enhance successful long‐term coping.
Association of Leptin Levels With Radiographic Knee Osteoarthritis Among a Cohort of Midlife Women
Authors: Karvonen‐Gutierrez Carrie A. , Harlow Siobán D. , Mancuso Peter , Jacobson Jon , Mendes de Leon Carlos F. , Nan Bin 
Published: December 2012

ObjectiveTo relate serum leptin levels to prevalent and incident radiographic knee osteoarthritis (OA) and to determine if patterns of change in longitudinal serum leptin measures differ by knee OA status over a 10‐year period.MethodsParticipants in the Michigan Study of Women's Health Across the Nation underwent bilateral knee radiographs at baseline and followup visits 2, 4, and 11 for ascertainment of knee OA status (Kellgren/Lawrence score ≥2). Serum leptin measures were available from baseline and followup visits 1 and 3–7.ResultsThe baseline prevalence of knee OA (mean age 46 years) was 18%; the 2‐year incidence of knee OA at followup visits 2 and 4 was 18% and 14%, respectively. Serum leptin levels were associated with prevalent and incident knee OA. A 5 ng/ml increase in serum leptin level was associated with 38% higher odds of prevalent knee OA (odds ratio [OR] 1.38, 95% confidence interval [95% CI] 1.26–1.52) and 31% greater odds of incident knee OA (OR 1.31, 95% CI 1.21–1.41) after adjustment for covariates, including body mass index residuals. Leptin levels increased with time; on average, serum leptin levels increased by 0.38 ng/ml per year (P = 0.0004). Women with incident knee OA during the 10‐year followup period had consistently higher serum leptin levels as compared to women with no knee OA during followup.ConclusionOur findings support a metabolic role of obesity in knee OA. A better understanding of the mechanisms by which increased fat mass is associated with joint damage is needed. Management of cardiometabolic dysfunction, including elevated serum leptin levels, may be beneficial in forestalling the onset or progression of knee OA.