bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phytomelatonin: From Intracellular Signaling to Global Horticulture Market
Authors: Aghdam Morteza Soleimani , Arnao Marino B. 
Published: July 2024

ABSTRACTMelatonin (N‐acetyl‐5‐methoxytryptamine), a well‐known mammalian hormone, has been having a great relevance in the Plant World in recent years. Many of its physiological actions in plants are leading to possible features of agronomic interest, especially those related to improvements in tolerance to stressors and in the postharvest life of fruits and vegetables. Thus, through the exogenous application of melatonin or by modifying the endogenous biosynthesis of phytomelatonin, some change can be made in the functional levels of melatonin in tissues and their responses. Also, acting in the respective phytomelatonin biosynthesis enzymes, regulating the expression of tryptophan decarboxylase (TDC), tryptamine 5‐hydroxylase (T5H), serotonin N‐acetyltransferase (SNAT), N‐acetylserotonin O‐methyltransferase (ASMT), and caffeic acid O‐methyltransferase (COMT), and recently the possible action of deacetylases on some intermediates offers promising opportunities for improving fruits and vegetables in postharvest and its marketability. Other regulators/effectors such as different transcription factors, protein kinases, phosphatases, miRNAs, protein–protein interactions, and some gasotransmitters such as nitric oxide or hydrogen sulfide were also considered in an exhaustive vision. Other interesting aspects such as the role of phytomelatonin in autophagic responses, the posttranslational reprogramming by protein‐phosphorylation, ubiquitylation, SUMOylation, PARylation, persulfidation, and nitrosylation described in the phytomelatonin‐mediated responses were also discussed, including the relationship of phytomelatonin and several plant hormones, for chilling injury and fungal decay alleviating. The current data about the phytomelatonin receptor in plants (CAND2/PMTR1), the effect of UV‐B light and cold storage on the postharvest damage are presented and discussed. All this on the focus of a possible new action in the preservation of the quality of fruits and vegetables.
Stories of struggle and resilience: Examining the experiences of two Spanish teachers through history in person
Authors: Davin Kristin J. , Donato Richard 
Published: July 2024

AbstractThe purpose of this study was to examine the career trajectories of two teachers in the United States and their decision to leave teaching Spanish. Data for the study emerged from the teachers’ narratives about their school‐based experiences and the consequences of those experiences on their decisions to reorient their work in the educational community. We adopted the theoretical framework of history in person to analyze the interactions between the teachers’ own personal histories with the histories of the institutions in which they taught. Data collection began during the two teachers’ student‐teaching semester and continued for 5 years after their initial induction into the language teaching profession and included interviews and email communications. The context was North Carolina, a state experiencing a severe teacher shortage and conflicts regarding teacher compensation. Findings highlight the challenges these teachers faced and how their interactions with historically institutionalized struggles were consequential to their professional futures. Implications for research, policy, and teacher preparation are discussed.
Amphicarpic development in Cardamine chenopodiifolia
Authors: Emonet Aurélia , Pérez‐Antón Miguel , Neumann Ulla , Dunemann Sonja , Huettel Bruno , Koller Robert , Hay Angela 
Published: July 2024

Summary

Amphicarpy is an unusual trait where two fruit types develop on the same plant: one above and the other belowground. This trait is not found in conventional model species. Therefore, its development and molecular genetics remain under‐studied. Here, we establish the allooctoploid Cardamine chenopodiifolia as an emerging experimental system to study amphicarpy.

We characterized C. chenopodiifolia development, focusing on differences in morphology and cell wall histochemistry between above‐ and belowground fruit. We generated a reference transcriptome with PacBio full‐length transcript sequencing and analysed differential gene expression between above‐ and belowground fruit valves.

Cardamine chenopodiifolia has two contrasting modes of seed dispersal. The main shoot fails to bolt and initiates floral primordia that grow underground where they self‐pollinate and set seed. By contrast, axillary shoots bolt and develop exploding seed pods aboveground. Morphological differences between aerial explosive fruit and subterranean nonexplosive fruit were reflected in a large number of differentially regulated genes involved in photosynthesis, secondary cell wall formation and defence responses.

Tools established in C. chenopodiifolia, such as a reference transcriptome, draft genome assembly and stable plant transformation, pave the way to study amphicarpy and trait evolution via allopolyploidy.
Efficacy and Safety of Fruquintinib‐Based Treatment in Patients with Refractory Bone and Soft Tissue Sarcoma after Developing Resistance to Several TKIs: A Multicenter Retrospective Study
Authors: Yang Chenchen , Li Binghao , Dong Sen , Xu Jie , Sun Xin , Liang Xin , Liu Kuisheng , Sun Kunkun , Yang Yi , Ji Tao , Ye Zhaoming , Xie Lu , Tang Xiaodong 
Published: July 2024

ObjectiveMultitargeted tyrosine kinase inhibitors (TKIs) have been approved as second‐line therapy in refractory sarcoma, prolonging progression‐free survival (PFS) but with short‐lived duration of disease control. Fruquintinib is a TKI that specifically inhibits vascular endothelial growth factor receptor‐1,2,3 with no metabolism by liver enzymes. In this retrospective study, we assessed the efficacy and safety of fruquintinib‐based treatment in patients with refractory sarcoma after developing several lines of TKI resistance.MethodsWe retrospectively analyzed the clinical data of patients with refractory sarcoma after they had developed several lines of resistance to TKIs and who received fruquintinib‐based treatment from November 2021 to August 2023. The primary endpoint was the progression‐free survival rate at 4 months (4m‐PFSR). Secondary endpoints were the median PFS, overall survival (OS), objective response rate, disease control rate, and adverse effects (AEs). PFS and OS were estimated using the Kaplan–Meier method. A log‐rank test was used to compare survival curves between different clinical and pathological factors. Cox proportional hazards analysis was performed to identify PFS‐related prognostic factors.ResultsWe included 124 patients: 56 (45.2%) with osteosarcoma, 28 (22.6%) with Ewing sarcoma, seven (5.6%) with chondrosarcoma, and 33 (26.6%) with soft tissue sarcomas (STS). Only 18 (14.5%) patients received monotherapy with fruquintinib. With a median follow‐up time of 6.8 (interquartile range [IQR], 4.6–9.4) months, 22 (17.7%) patients had partial response and 78 (62.9%) had stable disease. The 4m‐PFSR was 58.4% (95% confidence interval [CI], 49.6%–67.1%). The median PFS and OS were 4.4 (95% CI, 3.9–5.0) months and 11.4 (95% CI, 10.3–12.5) months. In multivariate analysis, a high hazard ratio for progression was associated with target lesions located outside the lung and bone with 1.79 (95% CI, 1.10–2.93; p = 0.020). Eighty‐eight AEs were recorded in 47 (37.9%) patients; the most common were pneumothorax (18/124, 14.5%), diarrhea (8/124, 6.5%), oral mucositis (7/124, 5.6%), and thrombocytopenia (7/124, 5.6%).ConclusionsFruquintinib may be a potential option for patients with refractory sarcoma after developing several lines of TKI resistance, with a satisfactory efficacy and safety profile in combination therapy. However, the degree of contribution of fruquintinib to results is unclear when combined with other effective substances. Additional prospective trials of fruquintinib should be conducted, especially involving different pathological types and combination regimens.
Conventional suspension delivery versus tattooing pen‐assisted suspension delivery in non‐cultured epidermal cell suspension procedure for vitiligo: A randomized controlled trial
Authors: Meena Akshay , Vinay Keshavamurthy , Kumaran Muthu Sendhil , Kumar Sheetanshu , Bishnoi Anuradha , Parsad Davinder 
Published: July 2024

AbstractNon‐cultured epidermal suspension (NCES) is one of the most widely used surgical therapy for stable vitiligo patients in which recipient size preparation plays an important role in the outcome of NCES. The primary objective is to evaluate and compare the efficacy and safety of conventional suspension delivery after manual dermabrasion (CSMD) versus tattooing pen‐assisted suspension delivery (TPSD) in NCES. Paired vitiligo units (VU) in 36 patients, matched with respect to size and location were divided into two groups. The VU in Group 1 underwent suspension delivery by CSMD while the VU in Group 2 underwent same by TPSD. All the VU were followed up at regular intervals until 24 weeks. At the end of 24 weeks, 31 VU (86.1%) in Group 1 achieved >75% repigmentation which was significantly higher (p = .02, chi‐square test) as compared to 22 VU (61.1%) in Group 2. The color matching in both the groups VU was also comparable (p = .84, chi‐square test). The patient global assessment (PGA) was significantly higher in Group 1 VU as compared to Group 2. Treatment response in terms of repigmentation and PGA was significantly better in VU treated with CSMD as compared to TPSD. Recipient site complications were seen more commonly in Group 1 VU as compared to Group 2. Perilesional halo at the recipient site was seen in none of the VU in Group 2 which was significantly lower than 6 VU in Group 1 than (p = .02, chi‐square test). Better results may be possible with technical improvisations in tattooing pen needle diameter and depth of penetration.
Modulation of gene expression in skin wound healing by photobiomodulation therapy: A systematic review in vivo studies
Authors: Pilar Emily Ferreira Salles , Brochado Fernanda Thomé , Schmidt Tuany Rafaeli , Leite Amanda Costa , Deluca Alexia Antunes , Mármora Belkiss Câmara , Siebert Marina , Wagner Vivian Petersen , Martins Manoela Domingues 
Published: July 2024

AbstractBackgroundWound healing is a multistep process involving coordinated responses of a variety of cell types, cytokines, growth factors, and extracellular matrix (ECM) components leading to the physiological restoration of tissue integrity. Photobiomodulation therapy (PBMT) has been highlighted as an approach to improve the healing process, nonetheless at the molecular level, the effects of PBMT are not entirely understood.AimTo systematically review publications that investigated gene expression after PBMT during in vivo skin repair.MethodsAn electronic search was undertaken in Medline Ovid (Wolters Kluwer), PubMed (National Library of Medicine), Web of Science (Thomson Reuters), Scopus (Elsevier), Embase, and LILACS databases. The search strategy was conducted from the terms: low‐level light therapy, gene expression, and wound healing and their synonyms. The databases were consulted in December 2023 and no publication year limit was used.ResultsEleven studies were included in this review and the expression of 186 genes was evaluated. PBMT modified the expression of several targets genes studied, such as down‐regulation of genes related to extracellular matrix proteases (MMP2andMMP9) and pro‐inflammatory cytokines (IL10andIL6) and up‐regulation ofDNMT3AandBFGF.ConclusionThis review demonstrates that PBMT is capable of regulating gene expression during wound healing. Most evidence showed a positive impact of PBMT in regulating genes linked to inflammatory cytokines improving skin wound healing. Yet, the effects of PBMT in genes involved in other mechanisms still need to be better understood.
Reframing Avant‐Garde Texts as Visual Objects
Authors: Lucento Angelina 
Published: July 2024

AbstractThis review essay assesses six early Soviet avant‐garde texts that recently were republished by the European University Press in St. Petersburg. These volumes include incredibly exact, high‐resolution reprints of seminal avant‐garde texts with historical commentary and analytic essays, which offer new insight into the illustrated books’ contributions to the socialist project. This essay describes those contributions and their implications for our current understanding of the visual function of early Soviet poetry. It aims to open space for a discussion of the particular material visuality of avant‐garde books and other static visual objects within contemporary debates about the meaning of text and image in Soviet visual culture.
Determinants of fiscal rules policy credibility in West African Economic and Monetary Union countries
Authors: Da Dakpoulé , Diarra Mahamadou 
Published: July 2024

AbstractMore than a quarter century after implementing fiscal rules, and despite extensions of the convergence phase, West African Economic and Monetary Union (WAEMU) countries are still unable to comply with the fiscal rules established. In addition, these countries are facing multiple shocks, exerting pressure on public finances. Based on this context, this paper empirically investigates the drivers of fiscal rules policy credibility of seven WAEMU countries over the period 1994–2019. Using two measures of fiscal rules policy credibility and pooled mean group (PMG) econometric estimator of dynamic panel, we find that internal and external macroeconomic variables are the main determinants of fiscal rules policy credibility in WAEMU countries in the long run. The institutional and political variables have mitigated effects. Specifically, we find that debt accumulation, economic activity fluctuation (gross domestic product), fiscal space reduction, and international commodity price fluctuation harm fiscal rules policy credibility, meaning that these variables deviate the fiscal policy from its target value. Our results suggest that WAEMU governments should pay attention to global shocks to reduce their macroeconomic vulnerabilities and better manage their economic resilience. In addition, they should better manage debt by allocating it to productive sectors, or improve the quality of institutions by establishing a genuine democracy that improves decision‐making and reduces deviant behaviour.
Personality profiles and exercise behaviour across adulthood
Authors: Wang Jin‐Kai , Shao Yun‐Ru , Guo Lu , Mao Zhi‐Xiong 
Published: July 2024

AbstractPersonality has constituted a significant psychological component predicting physical exercise. Prior research mostly focused on how personality domains are associated with exercise behaviour. Yet, focusing more closely on combinations of personality domains may be valuable in the future. The present cross‐sectional study aimed to bridge this gap by investigating the associations between Big Five personality profiles and exercise behaviour based on a person‐centred approach in adults. Data from the China Family Panel Studies (CFPS) were used (N = 28,304), in which participants reported their Big Five personality and exercise behaviour. Latent profile analyses, grounded in young adulthood, middle adulthood, and later adulthood sub‐samples, identified five personality profiles: moderate, reserved, confident, resilient, and vulnerable. Across three age groups, significant differences between the five personality profiles in relation to exercise behaviour were revealed. Individuals with the resilient or confident profiles generally had longer exercise duration while people with the vulnerable profile tended to exercise less. Our findings give greater insight into the relationship between exercise and personality, suggesting that different combinations of personality traits may determine individuals' exercise behaviour. It opens promising avenues for identification of adults at risk of lacking exercise, and for development of personality‐targeted exercise interventions.
Freedom dreaming from the university‐community nexus: Relational praxis as counterspace
Authors: Sonn Christopher C. , Agung‐Igusti Rama P. , Komba Geskeva , Ruach Ruth Nyarout , Deng Ez Eldin 
Published: July 2024

AbstractIn this article we draw on storytelling and bricolage to reflect on critical accompaniment as relational praxis with cultural workers from the African diaspora inside/outside/in‐between the university‐community nexus in Australia. We write together weaving our voices as we re‐member our journey and our coming together fuelled by our shared desire, to tell our own stories on our terms; to contest virulent racisms and misrecognition of the African diaspora in media, academic, and political discourse; and to create spaces, settings, and narratives for identity, community and belonging. In reflecting on this journey we distil some insights on our efforts to enact just methods, our routes and roots of creating praxis inside/outside and with the university. We suggest that our relationships, forged through critical dialogue and examination of racism in settings that we intentionally create, is central to developing communality. Drawing from the rich history of African and diasporic archives, we also advocate for expanding ecologies of knowledge and practice and modalities for endarkened counter storytelling.
Assessing the efficacy of mesotherapy products: Ultra Exo Booster, and Ultra S Line Plus in hair growth: An ex vivo study
Authors: Zhou Shu Yi , Giang Nguyen Ngan , Kim Hyunjee , Chien Pham Ngoc , Le Linh Thi Thuy , Trinh Thuy‐Tien Thi , Nga Pham Thi , Kwon Han Jin , Ham Jung Ryul , Lee Won Ku , Gu Yeon Ju , Zhang Xin Rui , Jin Yong Xun , Nam Sun Young , Heo Chan Yeong 
Published: July 2024

AbstractIn this study, scalp tissues from Korean adults between 20 and 80 without skin disease were used. Scalp tissues were processed, and hair follicles were isolated and cultured with different treatments (including Bioscalp, Ultra Exo Booster, and Ultra S Line Plus) from Ultra V company. Over 12 days, observations and measurements of hair follicle characteristics were recorded at intervals (Days 0, 3, 6, 9, and 12). The study assessed the impact of these substances on hair follicle growth and morphology. Bioscalp, combined with Ultra Exo Booster and Ultra S Line Plus, showed significant hair elongation in ex vivo. Preservation of hair bulb diameter was observed, indicating potential for sustained hair growth by exosome‐based products. The hair growth cycle analysis suggested a lower transition to the catagen stage in test products from Ultra V compared to non‐treated groups. The research findings indicated that the tested formulations, especially the combination of Bioscalp, Ultra Exo Booster, and Ultra S Line Plus, demonstrated significant effectiveness in promoting hair growth, maintaining the integrity of the hair bulb, and reducing the transition to the catagen stage. The study suggests promising alternative treatments for hair loss, illustrating results that were as good as those of the conventional testing product groups.
Epidemiology of infectious diseases in migrant populations from endemic or high‐endemic countries: A multicentric primary care‐based study in Spain
Authors: Cruz Angeline , Sequeira‐Aymar Ethel , Gonçalves Alessandra Queiroga , Camps‐Vila Laura , Monclús‐González Marta M. , Revuelta‐Muñoz Elisa M. , Busquet‐Solé Núria , Sarriegui‐Domínguez Susana , Casellas Aina , Cuxart‐Graell Alba , Rosa Dalmau Llorca M. , Aguilar‐Martín Carina , Requena‐Méndez Ana 
Published: July 2024

AbstractObjectivesWe aimed to evaluate the epidemiology of seven infections (Chagas disease, strongyloidiasis, schistosomiasis, human immunodeficiency virus, hepatitis B and C virus, and active tuberculosis) in migrant populations attended at primary care facilities in Catalonia, Spain.MethodsThis is a cross sectional study conducted from March to December 2018 at eight primary care centres in Catalonia, Spain where health professionals were recommended to systematically screen multiple infections in migrants considering the endemicity of the pathogens in their country of birth. Routine health data were retrospectively extracted from electronic health records of the primary care centres. The proportion of cases among individuals tested for each infection was estimated with its 95% confident interval (CI). Mixed‐effects logistics regression models were conducted to assess any possible association between the exposure variables and the primary outcome.ResultsOut of the 15,780 migrants that attended primary care centres, 2410 individuals were tested for at least one infection. Of the 508 (21.1%) migrants diagnosed with at least one condition, a higher proportion originated from Sub‐Saharan Africa (207, 40.7%), followed by South‐East Europe (117, 23.0%) and Latin‐America (88, 17.3%; p value <0.001). The proportion of migrants diagnosed with Chagas disease was 5/122 (4.1%, 95%CI 0.5–7.7), for strongyloidiasis 56/409 (13.7%, 95%CI 10.3–17.0) and for schistosomiasis 2/101 (2.0%, 95%CI 0.0–4.7) with very few cases tested. The estimated proportion for human immunodeficiency virus was 67/1176 (5.7%, 95%CI 4.4–7.0); 377/1478 (25.5%, 95%CI 23.3–27.7) for hepatitis B virus, with 108/1478 (7.3%, 95%CI 6.0–8.6) of them presenting an active infection, while 31/1433 (2.2%, 95%CI 1.4–2.9) were diagnosed with hepatitis C virus. One case of active tuberculosis was diagnosed after testing 172 migrant patients (0.6%, 95%CI 0.0–1.7).ConclusionsWe estimated a high proportion of the studied infections in migrants from endemic areas. Country‐specific estimations of the burden of infections in migrants are fundamental for the implementation of preventive interventions.
Hoof wall masses removal in 30 standing sedated horses: Surgical technique, postoperative complications and long‐term outcome
Authors: Ross Catherine , White Jonathan M. , Hibner‐Szaltys Maria , Stephenson Richard S. , Withers Jonathan M. , Marcatili Marco 
Published: July 2024

AbstractObjectiveTo describe the surgical technique for removal of hoof wall masses in horses under standing sedation (SS) and local anesthesia (LA), and to report complications and long‐term outcome following surgery.Study designObservational retrospective study.AnimalsClient‐owned horses (n = 30).MethodsHorses undergoing keratoma removal under SS and LA in a single equine hospital between August 2016 and July 2023 were included in the study. Signalment, affected foot, history of lameness and/or foot abscesses, degree of lameness on admission, imaging findings (radiography and magnetic resonance imaging [MRI] when available), location of the mass, surgical technique, remedial farriery, postoperative care, complications and outcome were recorded. Long‐term follow‐up information was obtained by telephone questionnaire.ResultsA total of 30 horses met the inclusion criteria. Duration of lameness ranged from 1 to 289 days (mean 90 days). The degree of lameness varied from absent to grade 4/5 (AAEP) (mean grade 3/5). All horses underwent preoperative radiographic examination and 14/30 underwent MRI. All horses underwent partial hoof wall resection. The surgery was performed safely in all cases. Postoperative complications included marked lameness in the early postoperative period in 3/30 horses and exuberant granulation tissue formation in 2/30 horses. Long‐term (>6 months) follow‐up information was available for 28 horses, and 26/28 horses returned to previous levels of exercise. Recurrence was suspected in 1/30 horses.ConclusionsThe complication rate was lower than previously reported for keratoma removal under general anesthesia (GA).Clinical significanceRemoval of hoof wall masses under SS and LA can be considered as an alternative to removal under GA.