bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review of Spinal Muscular Atrophy (SMA) for Prenatal and Pediatric Genetic Counselors
Authors: Carré Amanda , Empey Candice 
Published: August 2015

AbstractSpinal muscular atrophy (SMA) is an autosomal recessive neuromuscular condition with degeneration of the anterior horn cells in the spinal column. Five SMA subtypes exist with classification dependent upon the motor milestones achieved. Study of the SMN1 (survival motor neuron) and SMN2 genes as well as the concepts of the “2 + 0” carriers, gene conversion, de novo mutations and intragenic mutations allow for a better understanding of SMA. Detailing the carrier and diagnostic testing options further deepens the genetic counselor's knowledge of SMA. A review of care guidelines and research options is included as this information gives a patient a well‐rounded view of SMA. Although SMA is most commonly associated with the SMN1 gene, a number of spinal muscular atrophies not caused by genetic changes in this gene may be included as differential diagnoses until confirmatory testing can be completed. SMA is a complex condition requiring a detailed knowledge on the genetic counselor's part in order to explain the disorder to the patient with clarity thus facilitating increased communication and decision making guidance with the patient.
An evaluation of the Gifu Model in a trial for a new regional oncofertility network in Japan, focusing on its necessity and effects
Authors: Furui Tatsuro , Takenaka Motoki , Makino Hiroshi , Terazawa Keiko , Yamamoto Akio , Morishige Ken‐ichiro 
Published: August 2015

AbstractPurposeWe evaluated our 2‐year experience of the regional oncofertility network in Gifu Prefecture (GPOFS) in order to establish a more sophisticated regional oncofertility networking model in Japan.MethodsQuestionnaires were distributed twice in January 2013 to 57 departments in 35 hospitals that provide cancer treatment in Gifu Prefecture, before the establishment of the regional oncofertility network. The number and type of disease of the referred adolescent and young adult (AYA) cancer patients who visited the oncofertility clinic in Gifu University Hospital via the GPOFS were analyzed.ResultsThe majority of regional oncologists are aware of the need to provide information about oncofertility to their patients, but they cannot provide sufficient information due to their lack of knowledge about reproductive medicine. Eighty‐one AYA patients were referred to our clinic for oncofertility counseling in the first 2 years after the establishment of the GPOFS.ConclusionsThe GPOFS as the first regional oncofertility network in Japan has just started and may be working to help both AYA cancer patients and their oncologists. The nationwide establishment of the regional oncofertility network model could help both AYA cancer patients and oncologists.
Social Security, Personhood, and the State
Authors: VON BENDA-BECKMANN Keebet 
Published: August 2015

AbstractThis paper looks at the relationship between personhood and the state by taking a relational perspective both on the concept of personhood and on that of the state, and with a focus on social security. It presents a broad concept of social security. Based on research in the Moluccas of East Indonesia, and among Moluccan migrants in the Netherlands, it is explained how social security shapes personhood in situations in which the state is only a minor contributor, and people depend on mechanisms other than support and care from the state. Finally, it will be explored how long-distance relations of social security are maintained and how the position that respective actors have within these relationships affects notions not only of appropriate care, but also of personhood.
A comparative assessment of the fatty acid profiles and antioxidant status of supermarket eggs
Authors: Gaffney Mark , O'Rourke Rachel , Taylor-Pickard Jules , Murphy Richard 
Published: August 2015

SummaryNutrient deposition in eggs is largely dictated by the dietary composition of laying hen feed, particularly in terms of specific fatty acids and antioxidants. In the present study, the nutritional quality of a range of commercially available egg varieties, marketed as omega-3 enriched; corn-fed; free range and standard caged, were assessed by determining fatty acid profiles and antioxidant status. Across each egg variety, significant differences were observed in key fatty acids such as palmitic, oleic, linoleic, alpha-linolenic and docosahexaenoic acid (DHA) (P ≤ 0.05). Egg yolks enriched with a stated dietary source of omega-3 fatty acid DHA were shown to have significantly improved levels of DHA (P ≤ 0.05), approximately 4.5-fold higher than standard caged eggs. Compared with free range, corn fed and caged, eggs from diets enriched with a source of omega-3 were shown to have considerably altered omega-6: omega-3 ratios, amounting to 1.5–2.1 fold reductions. Yolk antioxidant activity was improved for omega-3 enriched eggs, particularly in hexane fractionated samples. The inclusion of omega-3 fatty acids to the diet resulted in eggs with improved DHA contents and antioxidant status, highlighting the importance of poultry diet composition for egg nutritional quality.
Thermal Stress and Failure Location Analysis for Through Silicon via in 3D Integration
Authors: Tsai H.-Y. , Kuo C.-W. 
Published: August 2015

AbstractThrough silicon via (TSV) is the critical structure for three dimensional (3D) integration, which provides vertical interconnection between stacking dies. In TSV structure, large coefficient differences of thermal expansion exist between silicon substrate, dielectric material, and filled metal. Due to the large thermal mismatch, the high thermal stress occurring at the interface of different materials would result in delamination. Therefore, thermal-mechanical reliability is a key issue for 3D integration. In this study, we investigated the thermal-mechanical stress distribution of TSV under the condition of the accelerated thermal cycling loading by finite element analysis based on a 3D model of TSV structure. Due to the thermal expansion, that the TSV structure squeezed the surface area between TSVs at a high temperature resulted in compressive stresses at the surface area between TSVs. Therefore, a proper distance between the stress-sensitive device and the TSV should be kept. The stress analysis shows that the maximum thermal stress occurs in the outside region of TSV interface and in the annular region of TSV at a high temperature and at a low temperature, respectively. This study helps to obtain a clear thermal stress distribution of TSV and possible failure regions can be determined.
Clan Governance and State Stability: The Relationship between Female Subordination and Political Order
Authors: HUDSON VALERIE M. , BOWEN DONNA LEE , NIELSEN PERPETUA LYNNE 
Published: August 2015

We propose that the relative influence of clans is an important explanatory factor producing significant variation in state stability and security across societies. We explore the micro-level processes that link clan predominance with dysfunctional syndromes of state behavior. Clans typically privilege agnatic descent from the patriline and are characterized by extreme subordination of women effected through marriage practices. Particular types of marriage practices give rise to particular types of political orders and may be fiercely guarded for just this reason. We construct and validate a Clan Governance Index to investigate which variables related to women's subordination to the patriline in marriage are useful to include in such an index. We then show that clan governance is a useful predictor of indicators of state stability and security, and we probe the value added by its inclusion with other conventional explanatory variables often linked to state stability and security.“I against my brothers; my brothers and I against my cousins; my cousins, my brothers, and I against the world” (Bedouin saying)“At the heart of tribes, to varying levels, is a severe patriarchy” (Jacobson 2013, 58).
The Performativity of Networks
Authors: Healy Kieran 
Published: August 2015

AbstractThe “performativity thesis” is the claim that parts of contemporary economics and finance, when carried out into the world by professionals and popularizers, reformat and reorganize the phenomena they purport to describe, in ways that bring the world into line with theory. Practical technologies, calculative devices and portable algorithms give actors tools to implement particular models of action. I argue that social network analysis is performative in the same sense as the cases studied in this literature. Social network analysis and finance theory are similar in key aspects of their development and effects. For the case of economics, evidence for weaker versions of the performativity thesis is quite good, and the strong formulation is circumstantially supported. Network theory easily meets the evidential threshold for the weaker versions. I offer empirical examples that support the strong (or “Barnesian”) formulation. Whether these parallels are a mark in favor of the thesis or a strike against it is an open question. I argue that the social network technologies and models now being “performed” build out systems of generalized reciprocity, connectivity, and commons-based production. This is in contrast both to an earlier network imagery that emphasized self-interest and entrepreneurial exploitation of structural opportunities, and to the model of action typically considered to be performed by economic technologies.
Seroprevalence Survey of Varicella, Measles, Rubella, and Hepatitis A and B Viruses in a Multinational Healthcare Workforce in Saudi Arabia
Authors: Almuneef M. A. , Memish Z. A. , Balkhy H. H. , Otaibi B. , Helmi M. 
Published: August 2015

Objective.To determine the prevalence of the vaccine-preventable diseases caused by varicella, measles, rubella, and hepatitis A and B viruses in a multinational healthcare workforce.Design.Prospective cohort study.Setting.A 750-bed tertiary care center located in Riyadh, Saudi Arabia.Methods.In compliance with hospital policy, newly recruited healthcare workers (HCWs) were enrolled in the study from September 2001 to March 2005. Serum samples were collected from all HCWs during the initial hiring process and tested for IgG antibodies against each of the 5 viral agents. Nonimmune HCWs were subsequently vaccinated at the earliest opportunity.Results.A total of 4,006 newly hired (international and local) employees were included in the study. All underwent serologic testing for IgG antibodies against varicella, measles, rubella, hepatitis A, and hepatitis B viruses. Of the total, 63% were female and 37% were male. Middle Eastern employees comprised 47% of the total, followed by employees from the Far East (35%), the West (10%), and Africa (8%). Forty-two percent were nurses, 27% were in administration, 18% were medical technicians, and 13% were physicians. Among the 4,006 newly hired HCWs, 14% had negative IgG antibody test results for varicella virus, 13% for measles virus, 10% for rubella virus, 33% for hepatitis A virus, and 43% for hepatitis B virus. More women than men were susceptible to hepatitis A (40% vs. 24%;P&lt; .001), whereas more men were susceptible to hepatitis B (55% vs. 35%;P&lt; .001). Varicella susceptibility was more common among HCWs from the Far East (19%), whereas susceptibility to measles, rubella, hepatitis A, and hepatitis B was highest among HCWs from the Middle East. Both relative youth and male sex were associated with lack of antibodies against hepatitis B virus and rubella virus. In contrast, female sex and younger age were associated with lack of antibodies against hepatitis A virus (P&lt; .001).Conclusion.Seroprevalence surveys of vaccine-preventable diseases among HCWs, although labor intensive, are invaluable in caring for a multinational workforce.
Effects of Emotional Facial Expression on Time Perception in Patients with Parkinson’s Disease
Authors: Mioni Giovanna , Meligrana Lucia , Grondin Simon , Perini Francesco , Bartolomei Luigi , Stablum Franca 
Published: August 2015

AbstractPrevious studies have demonstrated that emotional facial expressions alter temporal judgments. Moreover, while some studies conducted with Parkinson's disease (PD) patients suggest dysfunction in the recognition of emotional facial expression, others have shown a dysfunction in time perception. In the present study, we investigate the magnitude of temporal distortions caused by the presentation of emotional facial expressions (anger, shame, and neutral) in PD patients and controls. Twenty-five older adults with PD and 17 healthy older adults took part in the present study. PD patients were divided into two sub-groups, with and without mild cognitive impairment (MCI), based on their neuropsychological performance. Participants were tested with a time bisection task with standard intervals lasting 400 ms and 1600 ms. The effect of facial emotional stimuli on time perception was evident in all participants, yet the effect was greater for PD-MCI patients. Furthermore, PD-MCI patients were more likely to underestimate long and overestimate short temporal intervals than PD-non-MCI patients and controls. Temporal impairment in PD-MCI patients seem to be mainly caused by a memory dysfunction. (JINS, 2016, 22, 890–899)
A steep-slope transistor based on abrupt electronic phase transition
Authors: Shukla Nikhil , Thathachary Arun V. , Agrawal Ashish , Paik Hanjong , Aziz Ahmedullah , Schlom Darrell G. , Gupta Sumeet Kumar , Engel-Herbert Roman , Datta Suman 
Published: August 2015

AbstractCollective interactions in functional materials can enable novel macroscopic properties like insulator-to-metal transitions. While implementing such materials into field-effect-transistor technology can potentially augment current state-of-the-art devices by providing unique routes to overcome their conventional limits, attempts to harness the insulator-to-metal transition for high-performance transistors have experienced little success. Here, we demonstrate a pathway for harnessing the abrupt resistivity transformation across the insulator-to-metal transition in vanadium dioxide (VO2), to design a hybrid-phase-transition field-effect transistor that exhibits gate controlled steep (‘sub-kT/q’) and reversible switching at room temperature. The transistor design, wherein VO2 is implemented in series with the field-effect transistor’s source rather than into the channel, exploits negative differential resistance induced across the VO2 to create an internal amplifier that facilitates enhanced performance over a conventional field-effect transistor. Our approach enables low-voltage complementary n-type and p-type transistor operation as demonstrated here, and is applicable to other insulator-to-metal transition materials, offering tantalizing possibilities for energy-efficient logic and memory applications.
Coupling of individual quantum emitters to channel plasmons
Authors: Bermúdez-Ureña Esteban , Gonzalez-Ballestero Carlos , Geiselmann Michael , Marty Renaud , Radko Ilya P. , Holmgaard Tobias , Alaverdyan Yury , Moreno Esteban , García-Vidal Francisco J. , Bozhevolnyi Sergey I. , Quidant Romain 
Published: August 2015

AbstractEfficient light-matter interaction lies at the heart of many emerging technologies that seek on-chip integration of solid-state photonic systems. Plasmonic waveguides, which guide the radiation in the form of strongly confined surface plasmon-polariton modes, represent a promising solution to manipulate single photons in coplanar architectures with unprecedented small footprints. Here we demonstrate coupling of the emission from a single quantum emitter to the channel plasmon polaritons supported by a V-groove plasmonic waveguide. Extensive theoretical simulations enable us to determine the position and orientation of the quantum emitter for optimum coupling. Concomitantly with these predictions, we demonstrate experimentally that 42% of a single nitrogen-vacancy centre emission efficiently couples into the supported modes of the V-groove. This work paves the way towards practical realization of efficient and long distance transfer of energy for integrated solid-state quantum systems.
Experimental superposition of orders of quantum gates
Authors: Procopio Lorenzo M. , Moqanaki Amir , Araújo Mateus , Costa Fabio , Alonso Calafell Irati , Dowd Emma G. , Hamel Deny R. , Rozema Lee A. , Brukner Časlav , Walther Philip 
Published: August 2015

AbstractQuantum computers achieve a speed-up by placing quantum bits (qubits) in superpositions of different states. However, it has recently been appreciated that quantum mechanics also allows one to ‘superimpose different operations’. Furthermore, it has been shown that using a qubit to coherently control the gate order allows one to accomplish a task—determining if two gates commute or anti-commute—with fewer gate uses than any known quantum algorithm. Here we experimentally demonstrate this advantage, in a photonic context, using a second qubit to control the order in which two gates are applied to a first qubit. We create the required superposition of gate orders by using additional degrees of freedom of the photons encoding our qubits. The new resource we exploit can be interpreted as a superposition of causal orders, and could allow quantum algorithms to be implemented with an efficiency unlikely to be achieved on a fixed-gate-order quantum computer.
Superhydrophobic-like tunable droplet bouncing on slippery liquid interfaces
Authors: Hao Chonglei , Li Jing , Liu Yuan , Zhou Xiaofeng , Liu Yahua , Liu Rong , Che Lufeng , Zhou Wenzhong , Sun Dong , Li Lawrence , Xu Lei , Wang Zuankai 
Published: August 2015

AbstractDroplet impacting on solid or liquid interfaces is a ubiquitous phenomenon in nature. Although complete rebound of droplets is widely observed on superhydrophobic surfaces, the bouncing of droplets on liquid is usually vulnerable due to easy collapse of entrapped air pocket underneath the impinging droplet. Here, we report a superhydrophobic-like bouncing regime on thin liquid film, characterized by the contact time, the spreading dynamics, and the restitution coefficient independent of underlying liquid film. Through experimental exploration and theoretical analysis, we demonstrate that the manifestation of such a superhydrophobic-like bouncing necessitates an intricate interplay between the Weber number, the thickness and viscosity of liquid film. Such insights allow us to tune the droplet behaviours in a well-controlled fashion. We anticipate that the combination of superhydrophobic-like bouncing with inherent advantages of emerging slippery liquid interfaces will find a wide range of applications.
Calcitonin gene-related peptide pre-administration acts as a novel antidepressant in stressed mice
Authors: Hashikawa-Hobara Narumi , Ogawa Takumi , Sakamoto Yusuke , Matsuo Yumi , Ogawa Mami , Zamami Yoshito , Hashikawa Naoya 
Published: August 2015

AbstractCalcitonin gene-related peptide (CGRP) is a neuropeptide that has potent vasodilator properties and is involved in various behavioral disorders. The relationship between CGRP and depression-like behavior is unclear. In this study, we used chronically stressed mice to investigate whether CGRP is involved in depression-like behavior. Each mouse was exposed to restraint and water immersion stress for 15 days. After stress exposure, mice were assessed using behavioral tests: open field test, forced swim test and sucrose preference test. Serum corticosterone levels, hippocampal proliferation and mRNA expression of neurotrophins were measured. After stress exposure, mice exhibited depression-like behavior and decreased CGRP mRNA levels in the hippocampus. Although intracerebroventricular CGRP administration (0.5 nmol) did not alter depression-like behavior after 15-day stress exposure, a single CGRP administration into the brain, before the beginning of the 15-day stress exposure, normalized the behavioral dysfunctions and increased nerve growth factor (Ngf) mRNA levels in stressed mice. Furthermore, in the mouse E14 hippocampal cell line, CGRP treatment induced increased expression of Ngf mRNA. The NGF receptor inhibitor K252a inhibited CGRP’s antidepressant-like effects in stressed mice. These results suggest that CGRP expression in the mouse hippocampus is associated with depression-like behavior and changes in Ngf mRNA levels.
A tool for developing an automatic insect identification system based on wing outlines
Authors: Yang He-Ping , Ma Chun-Sen , Wen Hui , Zhan Qing-Bin , Wang Xin-Li 
Published: August 2015

AbstractFor some insect groups, wing outline is an important character for species identification. We have constructed a program as the integral part of an automated system to identify insects based on wing outlines (DAIIS). This program includes two main functions: (1) outline digitization and Elliptic Fourier transformation and (2) classifier model training by pattern recognition of support vector machines and model validation. To demonstrate the utility of this program, a sample of 120 owlflies (Neuroptera: Ascalaphidae) was split into training and validation sets. After training, the sample was sorted into seven species using this tool. In five repeated experiments, the mean accuracy for identification of each species ranged from 90% to 98%. The accuracy increased to 99% when the samples were first divided into two groups based on features of their compound eyes. DAIIS can therefore be a useful tool for developing a system of automated insect identification.
Co-evolution in a landrace meta-population: two closely related pathogens interacting with the same host can lead to different adaptive outcomes
Authors: Rau Domenico , Rodriguez Monica , Leonarda Murgia Maria , Balmas Virgilio , Bitocchi Elena , Bellucci Elisa , Nanni Laura , Attene Giovanna , Papa Roberto 
Published: August 2015

AbstractWe examined the local adaptation patterns in a system comprising several interconnected heterogeneous plant populations from which populations of two phylogenetically closely related pathogens were also sampled. The host isHordeum vulgare(cultivated barley); the pathogens arePyrenophora teresf.teres(net form) andPyrenophora teresf.maculata(spot form), the causal agents of barley net blotch. We integrated two approaches, the comparison between the population structures of the host and the pathogens and a cross-inoculation test. We demonstrated that two closely related pathogens with very similar niche specialisation and life-styles can give rise to different co-evolutionary outcomes on the same host. Indeed, we detected local adaptation for the net form of the pathogen but not for the spot form. We also provided evidence that ana-prioriwell-known resistance quantitative-trait-locus on barley chromosome 6H is involved in the co-evolutionary ‘arms race’ between the plant and the net-form pathogen. Moreover, data suggested latitudinal clines of host resistance and that different ecological conditions can result in differential selective pressures at different sites. Our data are of interest foron-farmconservation of plant genetic resources, as also in establishing efficient breeding programs and strategies for deployment of resistance genes ofP. teres.