bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk and outcome of non‐Hodgkin lymphoma among classical Hodgkin lymphoma survivors
Authors: Xavier Ana C. , Armeson Kent E. , Hill Elizabeth G. , Costa Luciano J. 
Published: June 2013

BACKGROUNDSurvivors of classical Hodgkin lymphoma (cHL) are at an increased risk of developing secondary non‐Hodgkin lymphomas (sNHLs). To the authors' knowledge, the outcome of patients with sNHL compared with their de novo counterparts (dnNHL) is unknown.METHODSData from 26,826 cases of HL from the Surveillance, Epidemiology, and End Results (SEER) program that were diagnosed between 1992 and 2009 were used to obtain the risk of further development of different subtypes of sNHL. The survival of patients with sNHL was compared with that of matched patients with dnNHL.RESULTSThe estimated cumulative incidence of sNHL was 2.50% (95% confidence interval [95% CI], 2.10‐2.89) at 15 years from the diagnosis of cHL. The standardized incidence ratio was 10.5 (95% CI, 8.9‐12.4) for aggressive B‐cell NHL, 4.0 (95% CI, 3.1‐5.1) for indolent B‐cell NHL, and 14.6 (95% CI, 10.3‐20.1) for T‐cell NHL. Patients with indolent B‐cell sNHL had a worse overall survival compared with their dnNHL counterparts (hazards ratio [HR] of death, 2.7; 95% CI, 1.3‐5.7). Survival was not significantly different between patients with sNHL and those with dnNHL with regard to aggressive B‐cell NHL (HR, 1.3; 95% CI, 0.6‐2.7) or T‐cell NHL (HR, 0.8; 95% CI, 0.3‐1.8).CONCLUSIONSThe risk of developing sNHL after cHL is substantial. Although patients with indolent B‐cell sNHL have inferior survival, patients with aggressive B‐cell sNHL and T‐cell sNHL have survival comparable to that of their de novo counterparts. Cancer 2013;119:3385–92. © 2013 American Cancer Society.
A phase 2 trial of intravenous and intraperitoneal paclitaxel combined with S‐1 for treatment of gastric cancer with macroscopic peritoneal metastasis
Authors: Yamaguchi Hironori , Kitayama Joji , Ishigami Hironori , Emoto Shigenobu , Yamashita Hiroharu , Watanabe Toshiaki 
Published: June 2013

BACKGROUNDThe prognosis of patients with gastric cancer with peritoneal metastasis is extremely poor. This phase 2 study evaluated the benefits and tolerability of weekly intravenous and intraperitoneal paclitaxel (PTX) treatment combined with oral S‐1 in patients with gastric cancer who had macroscopic peritoneal metastasis.METHODSPatients with gastric cancer who had primary tumors with macroscopic peritoneal metastasis were enrolled. PTX was administered intravenously at 50 mg/m2 and intraperitoneally at 20 mg/m2 on days 1 and 8, respectively. S‐1 was administered at 80 mg/m2 per day for 14 consecutive days, followed by 7 days of rest. The primary endpoint was the 1‐year overall survival (OS) rate. The secondary endpoints were the response rate, efficacy against malignant ascites, and safety.RESULTSThirty‐five patients were enrolled. The median number of treatment courses was 11 (range, 2‐35). The 1‐year OS rate was 77.1% (95% confidence interval, 60.5‐88.1). The overall response rate was 71% in 7 patients with target lesions. Malignant ascites disappeared or decreased in 15 of 22 (68%) patients. The frequent grade 3/4 toxic effects were neutropenia (34%), leukopenia (23%), and anemia (9%).CONCLUSIONSCombination chemotherapy consisting of intravenous and intraperitoneal PTX with S‐1 is well‐tolerated and effective in patients with gastric cancer who have macroscopic peritoneal metastasis. Cancer 2013;119:3354–8. © 2013 American Cancer Society.
Hollow α‐MnS Spheres and Their Hybrids with Reduced Graphene Oxide: Synthesis, Microwave Absorption, and Lithium Storage Properties
Authors: Chen Dezhi , Quan Hongying , Wang Guang‐Sheng , Guo Lin 
Published: June 2013

AbstractNovel α‐MnS hollow spheres (MHSs) have been fabricated successfully by a one‐pot template‐free solvothermal method. The as‐synthesized α‐MnS spheres have diameters of about 3–5 μm and porous shells of thickness about 0.5 μm composed of numerous nanocrystals. The samples were characterized by X‐ray diffraction, scanning electron microscopy, transmission electron microscopy, and nitrogen adsorption. Time‐dependent morphology evolution suggested that transformation of chemical components and Ostwald ripening play vital roles for these hollow structures with a porous shell. The possible formation mechanism for the fabrication of MHSs is proposed. Meanwhile, MHS–reduced graphene oxide (RGO) hybrids have been prepared in the presence of graphene oxide (GO) by using the same procedure. The amount of GO can affect the morphology of α‐MnS crystals in hybrids. The microwave absorption and lithium storage properties of the pure MHSs and MHS–RGO hybrids were studied in detail. Compared with pristine MHSs, the MHS–RGO hybrids possess remarkably enhanced microwave absorption and lithium storage properties. The enhanced microwave absorbing and electrochemical properties are also explained.
Privacy‐preserving authentication protocols with efficient verification in VANETs
Authors: Zhang Jianhong , Xu Yuwei 
Published: June 2013

SUMMARYAs an important component of intelligent transportation systems, vehicular ad hoc networks can provide safer and more comfortable driving circumstance for the drivers. However, communication security and privacy issues present practical concerns to the deployment of vehicular ad hoc networks. Although recent related studies have already addressed most of these issues, most of them have only considered a posteriori countermeasures or a priori countermeasures to prevent the attacks of an adversary. To the best of our knowledge, up to now, only two privacy‐preserving authentication schemes can provide a posteriori countermeasures and a priori countermeasures. But, the computational cost of verifying a signature is relatively high or security proof of the scheme is loose in the two schemes. In this paper, we propose two novel privacy‐preserving authentication schemes. The first one cannot only provide a posteriori and a priori countermeasures, but also has low computational cost in the verification phase and tight security proof. The second one can achieve batch verification on multiple messages. Comparison with Wu et al.'s scheme and Chen et al's scheme, our scheme shows higher efficiency in terms of the computational cost of verifying signature.Copyright © 2013 John Wiley & Sons, Ltd.
Simplified gateway selection scheme for multihop relay in vehicular ad hoc network
Authors: Alawi Mahmoud A. , Saeed Rashid. A. , Hassan Aisha A. , Alsaqour Raed A. 
Published: June 2013

SUMMARYIntegrating vehicular ad hoc network (VANET) and universal mobile telecommunication system (UMTS) could be a promising architecture for future machine‐to‐machine applications. This integration can help vehicles have steady Internet connection through the UMTS network and in communicating with other vehicles. However, dead spot areas and unsuccessful handoff processes caused by the high speed of vehicles can disrupt the implementation of this kind of architecture. In this paper, a new simplified gateway selection (SGS) scheme for multihop relay in a VANET‐UMTS integration network is proposed. The proposed scheme extends the coverage or/and calming of the frequent handoff process and allows vehicles to continue to be connected to the UMTS infrastructure network. An integrated simulation environment that combines VanetMobiSim and NS2 is used to simulate and evaluate the proposed scheme. The simulation results show that the SGS scheme performed better when it was implemented with ad hoc on a demand distance vector routing and destination‐sequenced distance vector routing protocols. Furthermore, the SGS scheme is compared with other cluster‐based gateway selections used in the previous works. The results show that our SGS scheme outperforms other cluster‐based gateway selections scheme in terms of selection delay, control packet overhead, packet delivery ratio, and overall throughput. Copyright © 2013 John Wiley & Sons, Ltd.
Cryptanalysis and improvement of ‘a robust smart‐card‐based remote user password authentication scheme’
Authors: Kumari Saru , Khan Muhammad Khurram 
Published: June 2013

SUMMARYWith the use of smart card in user authentication mechanisms, the concept of two‐factor authentication came into existence. This was a forward move towards more secure and reliable user authentication systems. It elevated the security level by requiring a user to possess something in addition to know something. In 2010, Sood et al. and Song independently examined a smart‐card‐based authentication scheme proposed by Xu et al. They showed that in the scheme of Xu et al., an internal user of the system can turn hostile to impersonate other users of the system. Both of them also proposed schemes to improve the scheme of Xu et al. Recently, Chen et al. identified some security problems in the improved schemes proposed by Sood et al. and Song. To fix these problems, Chen et al. presented another scheme, which they claimed to provide mutual authentication and withstand lost smart card attack. Undoubtedly, in their scheme, a user can also verify the legitimacy of server, but we find that the scheme fails to resist impersonation attacks and privileged insider attack. We also show that the scheme does not provide important features such as user anonymity, confidentiality to air messages, and revocation of lost/stolen smart card. Besides, the scheme defies the very purpose of two‐factor security. Furthermore, an attacker can guess a user's password from his or her lost/stolen smart card. To meet these challenges, we propose a user authentication method with user anonymity. We show through analysis and comparison that the proposed scheme exhibits enhanced efficiency in contrast to related schemes, including the scheme of Chen et al. Copyright © 2013 John Wiley & Sons, Ltd.
Implementing Liquid‐Crystalline Properties in Single‐Stranded Dinuclear Lanthanide Helicates
Authors: Terazzi Emmanuel , Zaïm Amir , Bocquet Bernard , Varin Johan , Guénée Laure , Dutronc Thibault , Lemonnier Jean‐François , Floquet Sébastien , Cadot Emmanuel , Heinrich Benoît , Donnio Bertrand , Piguet Claude 
Published: June 2013

AbstractInvited for the cover of this issue is the group of Emmanuel Terazzi at the University of Geneva, Switzerland. The cover image shows how single‐stranded dinuclear lanthanide helicates (green) survive immersion into a drop of less polar solvent (e.g. CH2Cl2) and their eventual self‐organization into a liquid‐crystalline material.
Iron‐Catalyzed Direct C–H Arylation of Heterocycles and Quinones with Arylboronic Acids
Authors: Deb Arghya , Manna Srimanta , Maji Arun , Dutta Uttam , Maiti Debabrata 
Published: June 2013

AbstractThe arylation of C–H bonds to generate heteroaryl–aryl (Het–Ar) and arylated quinone (Quin–Ar) compounds has received great attention to achieve sustainable goals in synthetic chemistry. Despite significant advances, arylation of a broad range of Het–Ar and Quin–Ar derivatives remains a challenging task. Herein, a variety of heterocycles are arylated by using arylboronic acids in the presence of catalytic amounts of inexpensive Fe(NO3)3. The C‐arylated quinone compounds can be prepared by reacting arylboronic acids with either quinone or hydroquinone. The present method is operationally simple, scalable, does not require prefunctionalization of the heterocycle or quinone, and can tolerate a wide variety of functional groups in the coupling partners. These qualities are expected to render this method attractive for academic and industrial use.
A critical investigation of smoothed particle hydrodynamics applied to problems with free‐surfaces
Authors: Le Touzé D. , Colagrossi A. , Colicchio G. , Greco M. 
Published: June 2013

SUMMARYIn this paper, an in‐depth study of SPH method, in its original weakly compressible version, is achieved on dedicated 2D and 3D free‐surface flow test cases. These rather critical prototype problems shall constitute suitable test cases to get through when building a free‐surface SPH model. The present work aims at investigating various numerical aspects of this method, often little mentioned in literature. In particular, a great care is paid to the dynamic part of the solution, which is critical to the local hydrodynamic load prediction. The role of numerical errors in the development of acoustic frequencies in the pressure signals is discussed, as well as the influence of the choice of the sound velocity. On the shown test problems, it is also evidenced that some numerical tools are crucial to ensure the robustness and accuracy of the standard SPH method. The convergence of our model is heuristically proved on these nonlinear prototype tests, showing at the same time the very satisfactory level of accuracy reached. Through these tests, some other numerical specificities of the SPH method are discussed, such as the self‐redistribution of the particles occurring during the Lagrangian evolution. A higher order model is also proposed, and its advantages and drawbacks are discussed. Copyright © 2013 John Wiley & Sons, Ltd.
Dynamic Implied Correlation Modeling and Forecasting in Structured Finance
Authors: Löhr Sebastian , Mursajew Olga , Rösch Daniel , Scheule Harald 
Published: June 2013

AbstractCorrelations are the main drivers for credit portfolio risk and constitute a major element in pricing credit derivatives such as synthetic single‐tranche collateralized debt obligation swaps. This study suggests a dynamic panel regression approach to model and forecast implied correlations. Random effects are introduced to account for unobservable time‐specific effects on implied tranche correlations. The implied‐correlation forecasts of tranche spreads are compared to forecasts using historical correlations from asset returns. The empirical findings support our proposed dynamic mixed‐effects regression correlation model. © 2013 Wiley Periodicals, Inc. Jrl Fut Mark
Functionalized DNA Nanostructures for Nanomedicine
Authors: Liu Xiaowei , Liu Yan , Yan Hao 
Published: June 2013

AbstractDNA nanotechnology utilizes synthetic DNA strands as the building material to construct nanoscale devices, and the field has developed rapidly over the past decade. Recently, the use of DNA nanostructures for various applications, particularly biomedical ones, has drawn great interest. This review focuses on the most recent research directed at utilizing functionalized DNA devices for nanomedical applications and presents representative research progress in disease diagnosis, treatment and prevention. In addition, the safety and future clinical applications of DNA nanostructures are discussed.
Enantioselective Gold(I) Catalysis with Chiral Monodentate Ligands
Authors: Cera Gianpiero , Bandini Marco 
Published: June 2013

AbstractEnantioselective gold(I) catalysis is receiving a growing level of credit in the field of asymmetric synthesis. After a pioneering work in the mid‐1980s the area remained almost silent for several years, until densely substituted diphosphine chiral ligands were disclosed as competent chiral units for gold‐catalyzed stereoselective manipulation of unactivated unsaturated hydrocarbons. The chemistry of alkynes, allenes and most recently also alkenes received significant benefits from the latter developments. More recently, ad hoc designed chiral monodentate ligands have risen to prominence in producing robust, highly tunable (electronic and steric) and efficient chiral cationic mononuclear gold species for asymmetric transformations. In this scenario, electron‐deficient phosphorus‐based (i.e., phosphoramidites, phosphites) but also axially chiral electron‐rich carbene ligands deserve particular mention and the corresponding applications will be summarized herein.
GPNMB enhances bone regeneration by promoting angiogenesis and osteogenesis: Potential role for tissue engineering bone
Authors: Hu Xuefeng , Zhang Ping , Xu Zhenjie , Chen Hongdong , Xie Xin 
Published: June 2013

ABSTRACTBone regeneration is a coordinated process involving the connection between blood vessels and bone cells. Glycoprotein non‐metastatic melanoma protein B (GPNMB) is known to be vital in bone formation. However, the effect of GPNMB on bone regeneration and the underlying molecular mechanism are still undefined. Fibroblast growth factor receptor (FGFR)‐mediating signaling is pivotal in bone formation and angiogenesis. Therefore, we assessed GPNMB function as a communicating molecule between osteoblasts and angiogenesis, and the possible correlation with FGFR‐1 signaling. Recombinant GPNMB dose‐dependently increased the differentiation of human bone marrow stromal cells (hBMSCs) into osteoblasts, as well as the mRNA levels of osteoblasts marker alkaline phosphatase (ALP) and osteocalcin (OCN). Furthermore, these increases depended on the activation of FGFR‐1 signaling, as pretreatment with FGFR‐1 siRNA or its inhibitor SU5402 dramatically dampened GPNMB‐induced osteogenesis. Additionally, GPNMB triggered dose‐dependently the proliferation and migration of human umbilical vein endothelial cells (hUVECs), FGFR‐1 phosphorylation, as well as capillary tube and vessels formation in vitro and in vivo. Blocking FGFR‐1 signaling dampened GPNMB‐induced angiogenic activity. Following construction of a rodent cranial defect model, scaffolds delivering GPNMB resulted in an evident increase in blood vessels and new bone formation; however, combined delivery of GPNMB and SU5402 abated these increase in defect sites. Taken together, these results suggest that GPNMB stimulates bone regeneration by inducing osteogenesis and angiogenesis via regulating FGFR‐1 signaling. Consequently, our findings will clarify a new explanation about how GPNMB induces bone repair, and provide a potential target for bone regeneration therapeutics and bone engineering. J. Cell. Biochem. 114: 2729–2737, 2013. © 2013 Wiley Periodicals, Inc.
Transient Insomnia Versus Chronic Insomnia: A Comparison Study of Sleep‐Related Psychological/Behavioral Characteristics
Authors: Yang Chien‐Ming , Lin Shih‐Chun , Cheng Chung‐Ping 
Published: June 2013

ObjectivesVulnerability to transient insomnia is regarded as a predisposing factor for chronic insomnia. However, most individuals with transient insomnia do not develop chronic insomnia. The current study investigated the differential contributing factors for these two conditions to further the understanding of this phenomenon.MethodChronic insomnia patients and normal sleepers with high and low vulnerability to transient insomnia completed measures of pre‐sleep arousal, dysfunctional sleep beliefs, and sleep‐related safety behaviors.ResultsBoth cognitive and somatic pre‐sleep arousals were identified as significant predictors for transient insomnia. Dysfunctional beliefs regarding worry about insomnia and cognitive arousal were predictors for chronic insomnia. Sleep‐related safety behavior, although correlated with insomnia severity, was not a significant predictor for both conditions.ConclusionsDysfunctional beliefs associated with worry and losing control over sleep are the most critical factors in differentiating chronic insomnia from transient insomnia. These factors should be addressed to help prevent individuals with high sleep vulnerability from developing chronic sleep disturbance.
Role of Meaning in the Prediction of Depressive Symptoms Among Trauma‐Exposed and Nontrauma‐Exposed Emerging Adults
Authors: Woo Candice R. S. , Brown Elissa J. 
Published: June 2013

ObjectivesThis study investigated the role of searching for meaning, finding meaning, trauma exposure, and their interaction in the prediction of depressive symptoms among trauma‐exposed and nontrauma‐exposed emerging adults.MethodEight thousand seven hundred and eighty‐four college students (73% female; mean age of 19.8 years) completed self‐report measures. Hierarchical regression analysis was conducted to evaluate the three‐way interaction in the prediction of depressive symptoms.ResultsSearching for and finding meaning as well as the three‐way interaction significantly contributed to the prediction of depression. Specifically, searching for meaning was associated with increased symptoms, irrespective of meaning levels among nontrauma‐exposed and low frequency trauma‐exposed emerging adults. Among high frequency trauma‐exposed individuals, an increase in the search‐by‐find meaning interaction predicted fewer symptoms.ConclusionsThe findings suggest that searching for and finding meaning are important mechanisms in the prediction of depression among emerging adults facing daily stressors and traumatic events. Clinical implications are discussed.
Pacific SST influence on spring precipitation in Addis Ababa, Ethiopia
Authors: Eden Jonathan M. , Widmann Martin , Evans Gavin R. 
Published: June 2013

ABSTRACTRecent periods of drought in Ethiopia and other parts of East Africa have highlighted the growing importance of producing reliable forecasts of seasonal precipitation. Key in deriving such forecasts is a good understanding of the atmospheric and oceanic drivers of different precipitation regimes. In Ethiopia and other parts of East Africa, interannual variability of precipitation depends on variations in sea surface temperature (SST) and atmospheric circulation on both regional and global scales. Links between summer precipitation in Ethiopia and large‐scale modes of climate variability such as El Niño Southern Oscillation (ENSO) have previously been established but the influence of global SST on spring precipitation has not yet been fully explored. Here, we analyse the links between Pacific SST and precipitation in Addis Ababa, Ethiopia for a century‐long period (1900–2004). A tripole correlation pattern between spring precipitation and SST in the Pacific basin is found. We develop regression‐based models to estimate spring precipitation from Pacific SST with a lead time of two to three months. When subject to cross‐validation, models based on principal component multiple linear regression (PC‐MLR) calibrated on Pacific SST during December show substantial skill in reproducing observed temporal variability in Addis Ababa precipitation during February (r = 0.48) and March (r = 0.40), and the period spanning February to April (r = 0.44). Our findings suggest that the inclusion of Pacific SST in predictive models may benefit drought forecasting across Ethiopia.
Usefulness of the Montreal Cognitive Assessment (MoCA) in Huntington's disease
Authors: Gluhm Shea , Goldstein Jody , Brown Daniel , Van Liew Charles , Gilbert Paul E. , Corey‐Bloom Jody 
Published: June 2013

ABSTRACTBackgroundThe Montreal Cognitive Assessment (MoCA) is a brief screening instrument for dementia that is sensitive to executive dysfunction. This study examined its usefulness for assessing cognitive performance in mild, moderate, and severe Huntington's disease (HD), compared with the use of the Mini–Mental State Examination (MMSE).MethodsWe compared MoCA and MMSE total scores and the number of correct answers in 5 cognitive‐specific domains in 104 manifest HD patients and 100 matched controls.ResultsFor the total HD sample, and for the moderate and severe patients, significant differences between both MoCA and MMSE total scores and almost all cognitive‐specific domains emerged. Even mild HD subjects showed significant differences with regard to total score and several cognitive domains on both instruments.ConclusionsWe conclude that the MoCA, although not necessarily superior to the MMSE, is a useful instrument for assessing cognitive performance over a broad level of functioning in HD. © 2013 International Parkinson and Movement Disorder Society