bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical analysis of cyanoacrylate in intestinal and colorectal anastomosis
Authors: Wu Zhouqiao , Boersema Geesien S. A. , Vakalopoulos Konstantinos A. , Daams Freek , Sparreboom Cloe L. , Kleinrensink Gert‐Jan , Jeekel Johannes , Lange Johan F. 
Published: October 2013

AbstractBackgroundAlthough cyanoacrylate glue (CA) has been widely used in various kinds of medical applications, its application in gastrointestinal anastomosis remains limited, and outcomes of experimental studies have not been satisfactory. This systematic review summarizes research regarding CA application in intestinal and colorectal anastomosis, and correlates methodological aspects to experimental outcomes.MethodsA systematic literature search was performed using Medline, Embase, Cochrane, and Web‐of‐Science libraries. Articles were selected if CA was applied to intestinal or colorectal anastomoses. Included articles were categorized according to CA molecular structure; the method details in each study were extracted and analyzed.ResultsTwenty‐two articles were included. More than half of the inclusions reported positive outcomes (seven articles) or neutral outcomes (eight articles). Analysis of the methods revealed that methodological details such as CA dosage, time of polymerization were not consistently reported. Porcine studies, inverted anastomosis, and n‐butyl‐cyanoacrylate studies showed more positive outcomes; everted anastomosis, and oversized sutures might negatively influence the outcomes.ConclusionsOwing to the positive outcome from the porcine studies, application of CA in gastrointestinal (GI) anastomosis still seems promising. To achieve a better consistency, more methodological details need to be provided in future studies. Optimizing the dosage of CA, choice of animal model, inverted anastomosis construction, and other method details may improve intestinal and colorectal anastomoses with CA application in future studies. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 102B: 635–642, 2014.
Screening study on hemolysis suppression effect of an alternative plasticizer for the development of a novel blood container made of polyvinyl chloride
Authors: Haishima Yuji , Kawakami Tsuyoshi , Hasegawa Chie , Tanoue Akito , Yuba Toshiyasu , Isama Kazuo , Matsuoka Atsuko , Niimi Shingo 
Published: October 2013

AbstractThe aim of this study is to identify a plasticizer that is effective in the suppression of the autohemolysis of the stored blood and can be used to replace di(2‐ethylhexyl) phthalate (DEHP) in blood containers. The results of hemolysis test using mannitol‐adenine‐phosphate/red cell concentrates (MAP/RCC) spiked with plasticizers included phthalate, phthalate‐like, trimeliate, citrate, and adipate derivatives revealed that di‐isononyl‐cyclohexane‐1,2‐dicarboxylate (Hexamoll® DINCH), di(2‐ethylhexyl)‐1,2,3,6‐tetrahydro‐phthalate (DOTP), and diisodecyl phthalate (DIDP) exhibited a hemolysis suppression effect almost equal to that of DEHP, but not other plasticizers. This finding suggested that the presence of 2 carboxy‐ester groups at the ortho position on a 6‐membered ring of carbon atoms may be required to exhibit such an effect. The hemolytic ratios of MAP/RCC‐soaked polyvinyl chloride (PVC) sheets containing DEHP or different amounts of DINCH or DOTP were reduced to 10.9%, 9.2–12.4%, and 5.2–7.8%, respectively (MAP/RCC alone, 28.2%) after 10 weeks of incubation. The amount of plasticizer eluted from the PVC sheet was 53.1, 26.1–36.5, and 78.4–150 µg/mL for DEHP, DINCH, and DOTP, respectively. PVC sheets spiked with DIDP did not suppress the hemolysis induced by MAP/RCC because of low leachability (4.8–6.0 µg/mL). These results suggested that a specific structure of the plasticizer and the concentrations of least more than ∼10 µg/mL were required to suppress hemolysis due to MAP/RCC. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 102B: 721–728, 2014.
Reassessment of tigecycline bone concentrations in volunteers undergoing elective orthopedic procedures
Authors: Bhattacharya Indranil , Gotfried Mark H. , Ji Allena J. , Saunders James P. , Gourley Ian , Diehl Annette , Korth‐Bradley Joan M. 
Published: October 2013

AbstractThe goal of the this study was to re‐evaluate tigecycline bone concentrations in subjects undergoing elective orthopedic surgery, using multiple doses and a more robust bone assay than was used in a previous study. Each subject received three intravenous doses of tigecycline (one 100‐mg infusion followed by two 50‐mg infusions, each administered over 30 minutes). A single bone sample was collected from each subject at one of the following times: 1, 2, 4, 6, 8, or 12 hours after the third dose. Four blood samples were collected from each subject: before the first dose, before and after the third dose, and within 15 minutes of the collection time of the bone sample. Noncompartmental pharmacokinetic analysis serum and bone area under the curve for the given dose interval (AUCτ) values were 2,402 ng h/mL and 11,465 ng h/g, and maximum concentration (Cmax) values were 974 ng/mL and 2,262 ng/g, respectively. The bone to serum ratio calculated using the AUCτ values was 4.77, confirming tigecycline penetration into bone.
Short‐ and long‐term results of lateral pancreaticojejunostomy for chronic pancreatitis: a retrospective Japanese single‐center study
Authors: Sudo Takeshi , Murakami Yoshiaki , Uemura Kenichiro , Hashimoto Yasushi , Kondo Naru , Nakagawa Naoya , Sueda Taijiro 
Published: October 2013

AbstractBackgroundThe study aim was to determine the short‐ and long‐term results of lateral pancreaticojejunostomy for chronic pancreatitis at a single center in Japan.MethodsThe records of 64 consecutive patients were retrospectively reviewed. All patients underwent surgery at Hiroshima University Hospital between December 1996 and April 2013. Long‐term follow‐up was performed in 58 patients (91%) for a median period of 34 months.ResultsThe 53 men (83%) and 11 women (17%) had a mean age of 55 years. The etiology of pancreatitis was chronic alcohol abuse in 44 patients (69%). The major indication for surgery was acute pancreatitis exacerbation (80%). There was no postoperative mortality. Postoperative morbidity occurred in 21 patients (33%), with severe complications requiring non‐surgical intervention in four (6%). The percentage of pain‐free patients after surgery was 91%, and further acute exacerbation was prevented in 95%. Four patients (7%) required subsequent surgery for pancreatitis‐related complications. Of the patients that completed follow‐up, 33 (57%) had diabetes mellitus, including 11 patients (19%) with new‐onset diabetes; 30 patients (56%) developed pancreatic exocrine insufficiency.ConclusionsFull‐length lateral pancreaticojejunostomy is safe, feasible, and effective for managing chronic pancreatitis. The technique prevents further exacerbations and maintains appropriate pancreatic endocrine and exocrine function.
Distribution of human papillomavirus genotypes, assessment of HPV 16 and 18 viral load and anal related lesions in HIV positive patients: A cross‐sectional analysis
Authors: Tamalet Catherine , Obry‐Roguet Veronique , Ressiot Emmanuelle , Bregigeon Sylvie , Del Grande Jean , Poizot‐Martin Isabelle 
Published: October 2013

AbstractNatural history of anal intraepithelial neoplasia and anal cancer is not fully understood. Factors associated with cytological abnormalities and predictors of progression to high‐grade anal intraepithelial neoplasia still deserve investigation. The aim of this cross‐sectional study was to assess the prevalence of HPV types, the relationship between HPV genotypes, HPV 16/18 viral load and cytological abnormalities in male and female HIV‐infected patients. One hundred and twenty‐two (72.6%) patients were infected with HPV, 75 (61%) had multiple HPV infection, and 94 (77%) had high‐risk HPV infection. The most frequently identified HPV types were HPV 16 (64%), HPV 6 (39%), HPV 18 (31%), HPV 53 (14.7%), HPV 33 (10.6%), HPV 11 (8.2%), HPV 70 (5.7%), and HPV 61 (4.9%). The HPV types which were most frequently found in combination were HPV 6 + 16 (9.8%), 6 + 16 + 18 (8.2%), 16 + 18 (6.6%), 6 + 18 (4.9%), 16 + 33 (3.3%), 16 + 53 (3.3%). Median HPV16 and 18 viral loads were 6.1 log10 copies/106 cells [IQR 5.0–7.3] and 6.1 log10 copies/106 cells [IQR 5.7–6.0], respectively. Male gender (P = 0.03, OR: 1.2 [1.0–1.4]) and homo/bisexual transmission routes (P = 0.044, OR: 1.4 [1.0–1.9]) were associated with HPV 16 infection. An HPV 16 viral load cut‐off ≥5.3 log10 copies/106 cells and a CD4+ cell count ≤200/µl were independent factors associated with abnormal cytology. In the absence of national consensus guidelines, a strict regular follow‐up at shorter intervals is recommended for HIV‐infected patients with abnormal cytology, especially low grade squamous intraepithelial lesions, an HPV 16 viral load ≥5.3 log/106 cells and a CD4+ cell count ≤200/µl. J. Med. Virol. 86:419–425, 2014. © 2013 Wiley Periodicals, Inc.
A non‐conforming multi‐element DGTD method for the simulation of human exposure to electromagnetic waves
Authors: Durochat Clément , Lanteri Stéphane , Léger Raphaël 
Published: October 2013

SUMMARYThe great majority of numerical calculations of electric energy deposition in human tissues exposed to microwaves are performed using the finite‐difference time‐domain (FDTD) method and voxel‐based geometrical models of the tissues. The straightforward implementation of the method and its computational efficiency are among the main reasons for FDTD being currently the leading method for numerical assessment of human exposure to electromagnetic waves. However, the rather difficult departure from the commonly used Cartesian grid and cell size limitations regarding the discretization of very detailed structures of human tissues are often recognized as the main weaknesses of the FDTD method in this application context. In particular, interfaces between tissues where sharp gradients of the electromagnetic field may occur are hardly modeled rigorously in these studies (this is generally referred as the staircasing effect). We present here an alternative numerical dosimetry methodology that is based on a DGTD method designed to work with non‐conforming cubic‐tetrahedral meshes for more flexibility in the discretization process of complex propagation scenes. For example, in the context of head tissues exposure to mobile phone radiation, the computation domain is divided in two regions: an unstructured tetrahedral mesh‐based heterogeneous model of head tissues and an orthogonal cartesian mesh of the vacuum part of the propagation domain. We present numerical results comparing this approach with strategies based on fully Cartesian and fully tetrahedral meshes of the whole computational domain. Copyright © 2013 John Wiley & Sons, Ltd.
Governing plant development in barley (Hordeum vulgare L.): relation to protein composition and breakdown rates of protein polymers during malting
Authors: Malik Ali H , Holm Lena , Johansson Eva 
Published: October 2013

AbstractBACKGROUNDThis study aimed at investigating opportunities to manipulate development rhythms of barley (Hordeum vulgare L.) and to relate such rhythms to protein concentration, composition and breakdown during malting. The spring malting barley cultivar Tipple was grown in daylight chambers at various sowing dates, nitrogen application timings and temperature levels to govern the development rhythms.RESULTSExtensive options were shown to be available for manipulating the plant development rhythm of spring malting barley. Individually, sowing times, N application timings and temperature levels were negatively correlated with the development time. The combination of early sowing and 100% N application at sowing/low temperature during the grain maturation period (GMP) resulted in a long development time before and after anthesis. The combination of late sowing and 50% N at sowing/high temperature during GMP led to short development time before and after anthesis. The highest protein concentration and lowest percentage of sodium dodecyl sulfate‐unextractable polymeric proteins in total polymeric proteins were found to be associated with short development time. Extensive degradation of proteins during malting was the result of short development time as compared to long development time.CONCLUSIONThe development rhythm of barley affects protein concentration, composition and breakdown and might thus not only influence the end‐use quality of barley but also the next generation of plants. © 2013 Society of Chemical Industry
A systematic review of Gymnema sylvestre in obesity and diabetes management
Authors: Pothuraju Ramesh , Sharma Raj Kumar , Chagalamarri Jayasimha , Jangra Surender , Kumar Kavadi Praveen 
Published: October 2013

AbstractThe prevalence of obesity is associated with many health‐related problems. Currently, more than 300 million people are considered to be obese. According to the World Health Organization (WHO), by 2030, 87 and 439 million people will be affected in India and the world, respectively. Today, herbal medicines are gaining interest in the treatment of obesity and diabetes, because of their minimal side effects. Gymnemic acid – an active component isolated from Gymnema sylvestre – has anti‐obesity and antidiabetic properties, decreases body weight and also inhibits glucose absorption. Several components extracted from Gymnema prevent the accumulation of triglycerides in muscle and liver, and also decrease fatty acid accumulation in the circulation. In this paper, an attempt has been made to review the effects of various extracts from Gymnema sylvestre in the regulation of carbohydrate and lipid metabolism in both animal and clinical studies. © 2013 Society of Chemical Industry
Prognostic role of internal jugular vein preservation in neck dissection for head and neck cancer
Authors: Gallo O. , Santoro R. , Fiorini F.R. , MecCariello G. , Laganà R.M. , Paiar F. , Maio V. 
Published: October 2013

ABSTRACTBackground and ObjectivesSparing internal jugular vein (IJV) in neck dissection for head and neck cancer is controversial. We aimed at evaluating the prognostic impact of IJV preservation.MethodsWe examined 206 files of head and neck cancer patients who underwent radical or modified radical neck dissection at the Otolaryngology University of Florence. The site of primary tumor was larynx and hypopharynx in 44.66%, oropharynx in 25.24%, oral cavity in 23.3%, unknown in 4.85%, salivary glands and rhinopharynx in 0.97%. In 60.19% the IJV was resected, in 39.81% preserved. Prognostic impact of IJV preservation was assessed by Kaplan–Meier and multivariate analysis.ResultsNeck recurrence occurred in 25.2%: the IJV was resected in 42.31%, in 57.69% preserved (P = 0.02). At multivariate analysis, neck recurrence resulted significantly associated to extracapsular spread (ECS) (P = 0.009), IJV preservation (P = 0.01), positive margins (P = 0.02). In ECS positive patients, a higher risk of neck recurrence was documented for IJV preservation (P = 0.012). A worse prognosis was observed for patients with IJV spared (P = 0.06).ConclusionsIJV preservation is associated with an increased risk of neck failure and a worse outcome, mainly in patients with ECS of nodes. J. Surg. Oncol. 2013; 108:579–583. © 2013 Wiley Periodicals, Inc.
Peritoneal debulking/intraperitoneal chemotherapy—non‐sarcoma
Authors: Kelly Kaitlyn J. , Nash Garrett M. 
Published: October 2013

AbstractThe combination of cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) is widely practiced for appendiceal, colorectal, gastric, and ovarian cancers with isolated peritoneal metastasis as well as for primary peritoneal cancer. The aim of this report is to explain the rationale and available techniques for CRS and IPC, and to highlight disease‐specific considerations that should be taken into account when evaluating potential candidates for CRS and IPC. J. Surg. Oncol. 2014 109:14–22. © 2013 Wiley Periodicals, Inc.
Risk of biochemical recurrence and positive surgical margins in patients with pT2 prostate cancer undergoing radical prostatectomy
Authors: Røder Martin Andreas , Thomsen Frederik Birkebæk , Berg Kasper Drimer , Christensen Ib Jarle , Brasso Klaus , Vainer Ben , Iversen Peter 
Published: October 2013

AbstractBackground and ObjectiveTo investigate risk factors associated with positive surgical margins (PSM) and biochemical recurrence (BR) in organ confined tumors (pT2) after radical prostatectomy (RP) for localized prostate cancer (PCa).MethodsBetween 1995 and 2011, 1,649 patients underwent RP at our institution. The study includes the 1,133 consecutive patients with pT2 tumors at final histopathology. Logistic regression analysis was used for risk of PSM. Risk of BR, defined as the first PSA ≥ 0.2 ng/ml, was analyzed with Kaplan–Meier and Cox regression analysis.ResultsMedian follow‐up was 3.6 years (range: 0.5–15.5 years). In logistic regression, NS surgery was independently associated with an increased risk of pT2 PSM (OR = 1.68, 95% CI: 1.3–2.0, P = 0.01) relative to non‐NS surgery. NS surgery was not independently associated with BR but the interaction of PSM and NS surgery trended (P = 0.08) to increase the risk of BR compared to PSM and non‐NS surgery.ConclusionSeveral factors influence the risk of pT2 PSMs in radical prostatectomy. In our cohort pT2 PSM is associated with NS surgery and trend to increase risk of BR compared to non‐NS surgery. The optimal selection of candidates for NS surgery is still not clear. J. Surg. Oncol. 2014 109:132–138. © 2013 Wiley Periodicals, Inc.
Subgroups of patients with very large gastrointestinal stromal tumors with distinct prognoses: A multicenter study
Authors: Wada Noriko , Kurokawa Yukinori , Nishida Toshirou , Takahashi Tsuyoshi , Toyokawa Takahiro , Kusanagi Hiroshi , Hirota Seiichi , Tsujinaka Toshimasa , Mori Masaki , Doki Yuichiro 
Published: October 2013

ABSTRACTBackground and ObjectivesAny gastrointestinal stromal tumors (GISTs) larger than 10 cm are classified as “high risk” according to the modified National Institutes of Health consensus criteria. We conducted a multicenter study to identify a subgroup with moderate prognosis even within the “high‐risk” group.MethodsWe retrospectively collected data on 107 patients with tumors ≥10 cm from a multicenter database of GIST patients. Patients with macroscopic residual lesions or tumor rupture were excluded. The relationship between recurrence‐free survival (RFS) and clinicopathological factors was analyzed.ResultsThe median tumor size and mitotic count were 12.5 cm and 8/50 HPF. The RFS rate was 58.5% at 3 years, 52.1% at 5 years. Only mitotic count was an independent prognostic factor of RFS in the multivariate analysis (P = 0.001). The hazard ratio for recurrence in the subgroup with mitotic count >5/50 HPF was 2.91 (95% confidence interval, 1.53 to 5.56). The subgroup with mitotic count ≤5/50 HPF showed significantly better RFS than the mitotic count >5/50 HPF subgroup (P < 0.001).ConclusionsMitotic count is closely associated with outcome in patients with large GISTs. This suggests that the subset of large GISTs with low mitotic counts may be considered as “intermediate‐risk” lesions. J. Surg. Oncol. 2014 109:67–70. © 2013 Wiley Periodicals, Inc.
Round window membrane vibration may increase the effect of intratympanic dexamethasone injection
Authors: Park Soon Hyung , Moon In Seok 
Published: October 2013

Objectives/HypothesisWe investigated whether the round window membrane (RWM) vibration can facilitate dexamethasone perfusion via the RWM in patients with sudden hearing loss.Study DesignProspective study.MethodsWe first performed an in vitro study using a semipermeable membrane. In the subsequent in vivo study, 20 mice were randomized into two groups: an intratympanic dexamethasone injection (ITDI)‐only group, and an ITDI with RWM vibration group. Concentration of dexamethasone was investigated using high performance liquid chromatography. Third, we performed a prospective clinical study. Fifty‐five refractory sudden hearing loss patients were divided into two groups: those who received ITDI only (n = 36) and those who received ITDI with RWM vibration (n = 19). Final hearing assessments were conducted 2 months after salvage treatment.ResultsIn the in vitro study, the concentration of dexamethasone increased with vibration time with the peak concentration observed at 3 minutes of vibration. In the in vivo study, ITDI with RWM vibration resulted in a significantly higher perilymph concentration of dexamethasone (7.68 ± 3.13 µg/ml) than that in the ITDI‐only group (2.66 ± 1.73 µg/ml). In a clinical setting, the overall improvement in hearing was similar between the two groups. However, when we compared the speech discrimination score between the two groups, we found that the relative discrimination gain in the ITDI with RWM vibration group (18.11 ± 23.54%) was higher than that in the ITDI‐only group (7.00 ± 15.54%) (P = 0.042).ConclusionRWM vibration can enhance the effect of intratympanic dexamethasone injection and is a viable treatment option for sudden hearing loss.Levels of EvidenceN/A. Laryngoscope, 124:1444–1451, 2014
trans‐10, cis‐12 conjugated linoleic acid enhances in vitro maturation of porcine oocytes
Authors: Jia Baoyu , Wu Guoquan , Fu Xiangwei , Mo Xianhong , Du Ming , Hou Yunpeng , Zhu Shien 
Published: October 2013

SUMMARYThe aim of this study was to determine the effects of trans‐10, cis‐12 conjugated linoleic acid (t10c12 CLA) supplementation on oocyte maturation and embryo development in pigs. Compared with the control, supplementation of 50 µM t10c12 CLA to in vitro maturation (IVM) medium significantly increased the proportion of oocytes at the metaphase‐II (MII) stage and subsequent parthenogenetic embryo development in terms of cleavage rate, blastocyst formation rate, and cell numbers in blastocysts. The t10c12 CLA‐treated oocytes resumed meiotic maturation and progressed to the MII stage significantly faster than those of control. The expression of phosphorylated mitogen‐activated protein kinase 3/1 (p‐MAPK3/1) and cyclooxygenase‐2 (COX2) in cumulus oocyte complexes (COCs) at 5, 10, and 22 hr of IVM were significantly increased in the t10c12 CLA‐treatment group. The level of p‐MAPK3/1 in t10c12 CLA‐treated MII oocytes was also higher (P < 0.05) than that of control. Moreover, t10c12 CLA supplementation partially overcame the negative effects of U0126 on cumulus expansion and nuclear maturation, and completely recovered COX2 protein levels in the presence of U0126. Treatment of COCs with NS398 also significantly suppressed cumulus expansion and nuclear maturation, which was overcome by t10c12 CLA. Yet, this simulatory effect of t10c12 CLA was blocked in the presence of both U0126 and NS398. The t10c12 CLA treatment significantly reduced reactive oxygen species level and increased glutathione concentrations in MII oocyte. In conclusion, supplementation of t10c12 CLA during porcine oocyte maturation exerts its beneficial effects on nuclear and cytoplasmic maturation, which contributes to enhancing subsequent embryo development. Mol. Reprod. Dev. 81: 20–30, 2014. © 2013 Wiley Periodicals, Inc.