bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Domino Reaction of 2,2‐Dihydroxyindene‐1,3‐dione with Aromatic Amines: Efficient Synthesis of Isochromeno[4,3‐b]indol‐5(11H)‐one Derivatives.
Authors: Meng Xiao‐Yan , Sun Mu‐Yan , Zhao Fu‐Jie , Dang Yi‐Jing , Jiang Bo , Tu Shu‐Jiang 
Published: April 2015

AbstractThe reaction proceeds with excellent regioselectivity.
ChemInform Abstract: Copper‐Catalyzed Regioselective Cross‐Dehydrogenative Coupling of Coumarins with Benzylic Csp3‐H Bonds.
Authors: Zhou Shi‐Liu , Guo Li‐Na , Duan Xin‐Hua 
Published: April 2015

AbstractOptimized conditions allow the synthesis of 3‐benzylcoumarins in moderate to good yields.
ChemInform Abstract: Synthesis of Aminonaphthopyranones and Aminonaphthochromenones by Blaise‐Reaction‐Initiated Cascade Procedures.
Authors: He Yan , Zhang Xinying , Fan Xuesen 
Published: April 2015

AbstractA convenient one‐pot protocol allows the preparation of the title species via a tandem reaction of benzonitrile derivatives with a Reformatsky reagent generated in situ from Zn and ethyl bromoacetate.
ChemInform Abstract: Chroman‐4‐ones via Microwave‐Promoted Domino Claisen Rearrangement—Oxa‐Michael Addition: Synthesis of Tabchromones A and B.
Authors: Schmidt Bernd , Riemer Martin , Schilde Uwe 
Published: April 2015

AbstractCompound (VI) can be easily transformed into tabchromone A (VII) and B (VIII).
ChemInform Abstract: Synthesis of 1‐Aminoisoquinolines via the Coinage Metal Cocatalyzed Reaction of 2‐Alkynylbenzaldoximes with Isocyanoacetates.
Authors: Wang Tao , Li Rou , Yu Danhong , Gu Chenghao , Xiong Fei , Chen Zhiyuan 
Published: April 2015

AbstractThe reaction generally succeeds for substrates with aryl and alkyl substituted alkynyl moieties, but fails in case of terminal, tert‐butyl, or trimethylsilyl substituted alkynyl groups.
ChemInform Abstract: Facile Preparation of 1,2‐Dihydroisoquinolines from N‐Benzylsulfonamides and Bromoacetylenes.
Authors: Urabe Hirokazu , Yamagishi Masahito , Ishii Azusa , Hata Takeshi 
Published: April 2015

AbstractOptimum reaction conditions are examined for the synthesis of the title compounds from N‐benzylsulfonamides (I) and bromoacetylenes (II).
ChemInform Abstract: Efficient Merging of Copper and Photoredox Catalysis for the Asymmetric Cross‐Dehydrogenative‐Coupling of Alkynes and Tetrahydroisoquinolines.
Authors: Perepichka Inna , Kundu Soumen , Hearne Zoe , Li Chao‐Jun 
Published: April 2015

AbstractThe report constitutes the first example for a highly efficient asymmetric cross‐dehydrogenative coupling in between tertiary amines, namely tetrahydroisoquinolines, and terminal alkynes.
ChemInform Abstract: Enantioselective Epoxidation of Dihydroquinolines by Using Iminium Salt Organocatalysts.
Authors: Bulman Page Philip C. , Day David P. , Chan Yohan 
Published: April 2015

AbstractThe epoxidation of dihydroquinolines (I) in the presence of optically active iminium salt catalyst gives epoxides with low to moderate enantioselectivities.
ChemInform Abstract: Iron‐Catalyzed C—H Bond Functionalization for the Exclusive Synthesis of Pyrido[1,2‐a]indoles or Triarylmethanols.
Authors: Karthikeyan Iyyanar , Sekar Govindasamy 
Published: April 2015

AbstractSelective iron‐catalyzed C‐H activation of 2‐benzylhydrylpyridine renders possible the formation of pyridoindoles via an intramolecular C‐H amination reaction.
ChemInform Abstract: Rhodium(III)‐Catalyzed One‐Pot Access to Isoquinolines and Heterocycle‐Fused Pyridines in Aqueous Medium Through C—H Cleavage.
Authors: Zhang Jitan , Qian Hongsheng , Liu Zhanxiang , Xiong Chunhua , Zhang Yuhong 
Published: April 2015

AbstractA variety of ketones and internal alkynes are converted into isoquinolines and heterocyclic fused pyridines.
ChemInform Abstract: Direct Arylation of Imidazo[1,5‐a]azines Through Ruthenium and Palladium Catalysis.
Authors: Sustac Roman Daniela , Poiret Valentin , Pelletier Guillaume , Charette Andre B. 
Published: April 2015

AbstractThe imidazo[1,5‐a]azine system is described as directing group for site‐selective Ru‐catalyzed C‐H arylation at the ortho‐position with aryl halides as coupling partners.
ChemInform Abstract: H8‐BINOL Chiral Imidodiphosphoric Acids Catalyzed Enantioselective Synthesis of Dihydroindolo‐/‐pyrrolo[1,2‐a]quinoxalines.
Authors: Fan Yan‐Sen , Jiang Yi‐Jun , An Dong , Sha Di , Antilla Jon C. , Zhang Suoqin 
Published: April 2015

AbstractThe scalable method relies on a Pictet‐Spengler reaction between indolyl anilines and ketones or aldehydes catalyzed by a newly developed H8‐BINOL‐based imidodiphosphoric acid providing the products in high yields and with excellent enantioselectivities.
ChemInform Abstract: Concise Synthesis of Tetrazole‐Ketopiperazines by Two Consecutive Ugi Reactions.
Authors: Zarganes‐Tzitzikas Tryfon , Patil Pravin , Khoury Kareem , Herdtweck Eberhardt , Doemling Alexander 
Published: April 2015

AbstractThe synthesis of a range of diversely substituted tetrazole‐fused ketopiperazines is achieved through Ugi‐tetrazole synthesis with ester substituted isonitriles (III) followed by ester hydrolysis and UGI 4CR reaction.
ChemInform Abstract: Synthesis of 2,7‐Disubstituted 5,10‐Diaryl‐5,10‐dihydrophenazines via Iron‐Catalyzed Intramolecular Ring‐Closing C—H Amination.
Authors: Nakamura Masaharu , Aoki Yuma , Imayoshi Ryuji , Hatakeyama Takuji , Takaya Hikaru 
Published: April 2015

AbstractOptimum reaction conditions are examined for the intramolecular ring closing C—N bond formation affording six 5,10‐diaryl‐5,10‐dihydrophenazines of type (II).They can find potential use as hole‐injection materials in organic electroluminescence devices.
ChemInform Abstract: Stereoselective Synthesis of cis‐2,6‐Disubstituted Morpholines and 1,4‐Oxathianes by Intramolecular Reductive Etherification of 1,5‐Diketones.
Authors: Gharpure Santosh J. , Anuradha Dandela , Prasad Jonnalagadda V. K. , Srinivasa Rao Pidugu 
Published: April 2015

AbstractA triethylsilane/TmsOTf‐mediated reductive etherification is developed to allow the cyclization of diketones of type (I) and (III) to give 2,6‐disubstituted morpholines and 1,4‐oxathianes in excellent trans‐diastereoselectivity.
ChemInform Abstract: Gold(I)‐Catalyzed Synthesis of Cyclic Sulfamidates: Current Scope, Stereochemistry and Competing Ene‐Allene Cycloisomerization.
Authors: Higginbotham Mari C. M. , Kennedy Lorna , Lindsay Anita G. , Troester Andreas , Bebbington Magnus W. P. 
Published: April 2015

AbstractThe first gold‐catalyzed preparation of cyclic sulfamidates, leading to a range of unusually substituted and sterically hindered products under mild conditions is reported.
ChemInform Abstract: A Rare Type of Sesquiterpene and β‐Santalol Derivatives from Santalum album and Their Cytotoxic Activities.
Authors: Matsuo Yukiko , Sakagami Hiroshi , Mimaki Yoshihiro 
Published: April 2015

Abstract8 New compounds (I)‐(VIII) are isolated from the heartwood of Santalum album together with 4 known compounds.
ChemInform Abstract: A New Bis‐seco‐Abietane Diterpenoid from Hyptis crenata Pohl ex Benth.
Authors: Yun Young Sook , Fukaya Haruhiko , Nakane Takahisa , Takano Akihito , Takahashi Shigeru , Takahashi Yuji , Inoue Hideshi 
Published: April 2015

AbstractThe new bis‐seco‐abietane diterpenoid named hyptisolide A (I) is isolated from the methanolic extracts of the aereal parts of Hyptis crenata Pohl ex Benth.
ChemInform Abstract: Cytotoxic (9βH)‐Pimarane and (9βH)‐17‐Norpimarane Diterpenes from the Tuber of Icacina trichantha.
Authors: Monday Onakpa Michael , Zhao Ming , Goedecke Tanja , Chen Wei‐Lun , Che Chun‐Tao , Santarsiero Bernard D. , Swanson Steven M. , Uzoma Asuzu Isaac 
Published: April 2015

AbstractOne new (9βH)‐pimarane, 17‐hydroxyicacinol (I), is isolated together with two known (9βH)‐pimaranes and two known (9βH)‐17‐norpimaranes.
ChemInform Abstract: Synthesis of Antibacterial 1,3‐Diyne‐Linked Peptoids from an Ugi‐4CR/Glaser Coupling Approach.
Authors: Brauer Martin C. N. , Neves Filho Ricardo A. W. , Westermann Bernhard , Heinke Ramona , Wessjohann Ludger A. 
Published: April 2015

AbstractA library of dimeric peptoids [ct.(VI)] are chemoselectively obtained by Ugi four‐component reaction followed by a copper‐catalyzed alkyne homocoupling (Glaser reaction).
ChemInform Abstract: A New Flavonol Glycoside from the Leaves of Boscia senegalensis.
Authors: Morgan Abubaker M. A. , Kim Jang Hoon , Kim Sang Kyum , Lim Chi‐Hwan , Kim Young Ho 
Published: April 2015

AbstractA new flavonol glycoside, bosenegaloside A, is isolated along with seven known compounds from Boscia senegalensis.
ChemInform Abstract: Palladium(0)‐Catalyzed Synthesis of Cyclic Glucosides.
Authors: Huang Xin , Fu Chunling , Ma Shengming 
Published: April 2015

AbstractO‐Acetyl protected allenyl β‐D‐glucoside reacts with aryl, hetaryl, and alkenyl iodides in a highly regio‐ and stereoselective manner, and the products are deacetylated to ten‐membered cyclic glycosides.
ChemInform Abstract: The Application of Formyl Group Activation of Bromopyrrole Esters to Formal Syntheses of Lycogarubin C, Permethyl Storniamide A and Lamellarin G Trimethyl Ether.
Authors: Gupton John T. , Telang Nakul , Patteson Jon , Lescalleet Kristin , Yeudall Scott , Sobieski John , Harrison Andrew , Curry Will 
Published: April 2015

AbstractThe natural products lycogarubin (I), permethyl storniamide A (II), and lamellarin G trimethyl ether (III) are interesting biological active compounds.
ChemInform Abstract: Sequential Sonagashira and Larock Indole Synthesis Reactions in a General Strategy to Prepare Biologically Active β‐Carboline‐Containing Alkaloids.
Authors: Pan Xiaohong , Bannister Thomas D. 
Published: April 2015

AbstractThe two palladium‐mediated title processes serve as key steps for the synthesis of various β‐carboline‐containing natural products.
ChemInform Abstract: Total Synthesis of Acetylcholinesterase Inhibitor Macakurzin C.
Authors: Lee Dongjoo , Shin Iljin , Ko Eunjae , Lee Kiyoun , Seo Seung‐Yong , Kim Hyoungsu 
Published: April 2015

AbstractThe concise synthesis of macakurzin C in nine steps is presented.
ChemInform Abstract: New Isoprenylated Xanthones from Cudrania tricuspidata.
Authors: Lei Chun , Liu Chang‐Chang , Pi En‐Hao , Hou Ai‐Jun 
Published: April 2015

Abstractisolation and structure elucidation of new isoprenylated xanthones, cudratricusxanthones N (I), O (II), and P (III) along with five known compounds
ChemInform Abstract: Isolation and Biomimetic Synthesis of (.+‐.)‐Calliviminones A and B, Two Novel Diels—Alder Adducts, from Callistemon viminalis.
Authors: Kong Lingyi , et al.  
Published: April 2015

AbstractCompounds (I) and (II) exhibit moderate inhibition on NO production on LPS‐activated RAW 264.0 cells.
ChemInform Abstract: 3‐epi‐Waol A and Waol C: Polyketide‐Derived γ‐Lactones Isolated from the Endophytic Fungus Libertella blepharis F2644.
Authors: Adames Itzel , Ortega Humberto E. , Asai Yumi , Kato Masaki , Nagaoka Kazuya , TenDyke Karen , Shen Young Yongchun , Cubilla‐Rios Luis 
Published: April 2015

Abstract3‐epi‐Waol A (I) exhibits growth inhibition against the parasite Trypanosoma cruzi (IC50=22.71 μM), and against MCF‐7 (IC50=22.46 μM), HCT116 (IC50=6.2 μM), and H460 (IC50=1.0 μM) cancer cell lines.
ChemInform Abstract: Synthesis and Biology of Cyclic Imine Toxins, an Emerging Class of Potent, Globally Distributed Marine Toxins
Authors: Stivala Craig E. , Benoit Evelyne , Araoz Romulo , Servent Denis , Novikov Alexei , Molgo Jordi , Zakarian Armen 
Published: April 2015

AbstractReview: 151 refs.
Malignant risk stratification of thyroid FNA specimens with indeterminate cytology based on molecular testing
Authors: Paskaš Svetlana , Janković Jelena , Živaljević Vladan , Tatić Svetislav , Božić Vesna , Nikolić Aleksandra , Radojković Dragica , Savin Svetlana , Cvejić Dubravka 
Published: April 2015

BACKGROUNDFine‐needle aspiration (FNA) has been employed for many years for examining thyroid nodules, and the cytology of aspirates is the primary determinant for whether thyroidectomy is indicated. Fifteen to thirty percent of thyroid nodules, not being clearly benign or malignant, fall into an indeterminate category. The main goals of molecular diagnostics for thyroid nodules are to prevent unnecessary surgery in patients with benign nodules and to stop patients with malignant nodules from being subjected to repeated operations.METHODSThis study was designed to evaluate the diagnostic utility of 4 markers in thyroid FNA cytology via testing for the BRAF V600E mutation and the expression of microRNA‐221, microRNA‐222, and galectin‐3 protein in FNA samples with indeterminate cytology.RESULTSA predictor model distinguishing benign samples from malignant samples on the basis of the 4 aforementioned markers was formulated. This decision model provided a sensitivity of 73.5%, a specificity of 89.8%, and a diagnostic accuracy of 75.7%. The positive predictive value was 80.6%, and the negative predictive value was 85.5%; this suggested that the prediction had good reliability.CONCLUSIONSOne hundred twenty FNA samples were examined, and 62 nodules were classified as benign with the proposed diagnostic algorithm. This resulted in a reduction of the initial 120 patients to 58 and thus decreased by half the number of persons undergoing surgery. Cancer (Cancer Cytopathol) 2015;123:471–9. © 2015 American Cancer Society.
Fe K‐Edge X‐ray Absorption Fine Structure Determination of γ‐Al2O3‐Supported Iron‐Oxide Species
Authors: Tomita Atsuko , Miki Takeshi , Tango Takeru , Murakami Tatsuro , Nakagawa Hideyuki , Tai Yutaka 
Published: April 2015

AbstractThe structure of FeOx species supported on γ‐Al2O3 was investigated by using Fe K‐edge X‐ray absorption fine structure (XAFS) and X‐ray diffraction (XRD) measurements. The samples were prepared through the impregnation of iron nitrate on Al2O3 and co‐gelation of aluminum and iron sulfates. The dependence of the XRD patterns on Fe loading revealed the formation of α‐Fe2O3 particles at an Fe loading of above 10 wt %, whereas the formation of iron‐oxide crystals was not observed at Fe loadings of less than 9.0 wt %. The Fe K‐edge XAFS was characterized by a clear pre‐edge peak, which indicated that the FeO coordination structure deviates from central symmetry and that the degree of FeOFe bond formation is significantly lower than that in bulk samples at low Fe loading (<9.0 wt %). Fe K‐edge extended XAFS oscillations of the samples with low Fe loadings were explained by assuming an isolated iron‐oxide monomer on the γ‐Al2O3 surface.
Redefining Outcome Measurement: A Model for Brief Psychotherapy
Authors: McGuinty Everett , Nelson John , Carlson Alain , Crowther Eric , Bednar Dina , Foroughe Mirisse 
Published: April 2015

SummaryContextThe zeitgeist for short‐term psychotherapy efficacy has fundamentally shifted away from evidence‐based practices to include evidence‐informed practices, resulting in an equally important paradigm shift in outcome measurement designed to reflect change in this short‐term modality.ObjectiveThe present article delineates a short‐term psychotherapy structure which defines four fundamental stages that all brief therapies may have in common, and are represented through Cognitive Behavioral Therapy, Solution‐Focused Brief Therapy, Narrative Therapy, and Emotion‐Focused Therapy.MethodThese four theoretical approaches were analyzed via a selected literature review through comparing and contrasting specific and common tasks as they relate to the process of psychotherapy and change. Once commonalities were identified within session, they were categorized or grouped into themes or general stages of change within the parameters of a four to six session model of short‐term therapy. Commonalities in therapeutic stages of change may more accurately and uniformly measure outcome in short‐term work, unlike the symptom‐specific psychometric instruments of longer‐term psychotherapy.ResultsA systematic framework for evaluating the client and clinician adherence to 20 specific tasks for these four short‐term therapies is presented through the newly proposed, Brief Task Acquisition Scale (BTAS). It is further proposed that the client–clinicians' adherence to these tasks will track and ultimately increase treatment integrity.ConclusionThus, when the client–clinician relationship tracks and evaluates the three pillars of (1) stage/process change, (2) task acquisition, and (3) treatment integrity, the culmination of these efforts presents a new way of more sensitively measuring outcome in short‐term psychotherapy. Data collection is suggested as a first step to empirically evaluate the testable hypotheses suggested within this current model. Copyright © 2015 John Wiley & Sons, Ltd.Key Practitioner Message

The clinician practitioner will note that the proposed Brief Services model removes the subjectivity of client satisfaction as a reliable outcome measure, and relies upon client and therapist adherence to specific tasks and stages of change within and across short‐term psychotherapy.
The clinical significance of the BTAS for the practitioner is three fold. The psychometric instrument (1) tracks stage or process change, (2) guides task acquisition, and (3) incorporates greater treatment integrity unlike other outcome measures.
The BTAS present a new way of conceptualizing change in short‐term psychotherapy regardless of modality or presenting issue, making it a more flexible and usable instrument for the clinician.
The BTAS may measure outcome more sensitively and accurately, thus offering the client, therapist and client‐therapist more information regarding change at each stage and at the end of short‐term psychotherapy.
Who's Pulling the Fracking Strings? Power, collaboration and Colorado fracking policy
Authors: Cook Jeffrey J. 
Published: April 2015

AbstractScholars have looked towards collaborative governance as one means to resolve complex environmental issues and this has travelled to the administrative policy realm in the form of negotiated rulemaking or more recently shuttle diplomacy. What is missing from this administrative literature, and that of collaborative governance literature more generally, is a discussion of the role of power in these processes. This paper provides a case study of the Colorado Oil and Gas Conservation Commission's (COGCC) collaborative rule‐making, the Statewide Groundwater Baseline Sampling and Monitoring Rule, to serve as a launch point to evaluate the role of power in state‐level collaborative processes. This research provides original interview data from agency staff and stakeholders to explore the ability of certain groups to exercise the power of agenda control to influence the outcome of the process in the controversial fracking arena. Here, the governor and agency staff were important in defining the problem, but determining the available solutions was more open to privileged stakeholders, namely industry. The interviewees suggested that these dynamics carry over to other COGCC rule‐makings and as such future scholars should evaluate the agenda control strategies of these groups to better understand why collaborative policy‐making, especially in the administrative realm, unfolds as it does. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
Determinants of submaximal exercise capacity in patients at risk for heart failure with preserved ejection fraction—results from the DIAST‐CHF study
Authors: Stahrenberg Raoul , Duvinage André , Mende Meinhard , Gelbrich Götz , auf der Heide Wiebke , Düngen Hans‐Dirk , Binder Lutz , Nolte Kathleen , Herrmann‐Lingen Christoph , Hasenfuß Gerd , Pieske Burkert , Wachter Rolf , Edelmann Frank 
Published: April 2015

AbstractObjectives and BackgroundThe aim of this study was to identify determinants of submaximal exercise capacity as measured by 6 min walking distance in patients at risk for heart failure with preserved ejection fraction (HFpEF).MethodsA cross‐sectional analysis from the prospective cohort programme Prevalence and Clinical Course of Diastolic Dysfunction and Heart Failure (DIAST‐CHF) that included a total of 1937 patients (age, 50–85 years) with >1 risk factor (hypertension, atherosclerotic disease, diabetes mellitus, and obstructive sleep apnoea) was carried out. Besides comprehensive clinical phenotyping, standardized 6 min walk test and state‐of‐the‐art echocardiography were performed, and blood samples for biomarker assessment were obtained. Patients with an ejection fraction <50% or without evaluable exercise test were excluded from this analysis.ResultsOne thousand three hundred eighty‐seven patients fulfilled all criteria for this analysis. In the univariate analysis, 6 min walk distance was inversely related to E/e′ values (P < 0.001). In the multivariate analysis, 6 min walk distance decreased significantly with age, female sex, increasing body mass index, diabetes, chronic obstructive lung disease, and peripheral artery disease. However, the association of 6 min walk distance with resting parameters of diastolic function was significantly attenuated with multivariate regression. In contrast, mid‐regional pro‐adrenomedullin, mid‐regional pro‐atrial natriuretic peptide, and N‐terminal pro‐B‐type natriuretic peptide were independently associated with submaximal exercise capacity when added to the base model (all P < 0.001).ConclusionsClassical risk factors for heart failure and neuroendocrine activation are independently associated with sub‐maximal exercise capacity, while diastolic function parameters obtained at rest were not. This observation substantiates the role of co‐morbidities as relevant contributors to the clinical picture of HFpEF and the limitation of resting indices of diastolic function for diagnosing HFpEF.
Syntheses of Ir4(CO)6(η5‐C5Me4H)2 and Ir7(μ3‐CO)3(CO)12(η5‐C5Me5) from Pentametallic Molybdenum‐Iridium Cluster Precursors
Authors: Fu Junhong , Randles Michael D. , Criddle Alan L. , Moxey Graeme J. , Schwich Torsten , Stranger Robert , Cifuentes Marie P. , Humphrey Mark G. 
Published: April 2015

AbstractReaction of Mo2Ir3(μ‐CO)3(CO)6(η5‐C5H5)2(η5‐C5Me5) with Ir(CO)2(η5‐C5Me4H) afforded the four‐valence‐electron‐deficient butterfly cluster Ir4(CO)6(η5‐C5Me4H)2; its stability has been rationalized with the aid of density functional theory calculations, which suggest that significant additional intracluster bonding alleviates the formal electron deficiency. Reaction of MoIr4(CO)10(η5‐C5H5)(η5‐C5Me5) with [N(PPh3)2][Ir(CO)4] afforded the capped octahedral cluster Ir7(μ3‐CO)3(CO)12(η5‐C5Me5), which possesses three semi‐face‐capping CO ligands. These outcomes demonstrate that heterometallic clusters may serve as a potential source of new homometallic clusters following appropriate M–M′ cleavage.