bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aldehyde dehydrogenase 2 family member repression promotes colorectal cancer progression by JNK/p38 MAPK pathways-mediated apoptosis and DNA damage
Authors: Yu Miao , Chen Qian , Lu Yi-Ping 
Published: July 2024

BACKGROUND
Aldehyde (ALDH2) dysfunction has been verified to contribute to human cancers.
AIM
To investigate the molecular mechanism and biological function of ALDH2 in colorectal cancer (CRC) progression.
METHODS
Human CRC cells with high expression of ALDH2 were screened. After shRNA ALDH2 (sh-ALDH2) transfection, phenotypes [proliferation, apoptosis, acetaldehyde (ACE) accumulation, DNA damage] of CRC cells were verified using cell counting kit-8, flow cytometry, ACE assay, and comet assays. Western blotting was used for evaluation of the apoptosis proteins (Bax and Bcl-2) and JNK/p38 MAPK pathway-associated proteins. We subjected CVT-10216 (a selective ALDH2 inhibitor) to nude mice for establishment of SK-CO-1 mouse xenograft model and observed the occurrence of CRC.
RESULTS
The inhibition of ALDH2 could promote the malignant structures of CRC cells, including apoptosis, ACE level, and DNA damage, and cell proliferation was decreased in the sh-ALDH2 group, whereas ALDH2 agonist Alda-1 reversed features. ALDH2 repression can cause ACE accumulation, whereas ACE enhanced CRC cell features related to increased DNA damage. Additionally, ALDH2 repression led to JNK/P38 MAPK activation, and apoptosis, ACE accumulation, and DNA damage were inhibited after p38 MAPK inhibitor SB203580 and JNK inhibitor SP600125 addition. ACE accumulation and raised DNA damage were recognized in CVT-10216 treated-mouse tumor tissues in vivo .
CONCLUSION
The repression of ALDH2 led to ACE accumulation, inducing cell apoptosis and DNA damage by the JNK/p38 MAPK signaling pathway activation in CRC.
Tramadol induces alterations in the cognitive function and histoarchitectural features of the hippocampal formation in adult Wistar rats.
Authors: Ekpo U.U. , Umana U.E. , Sadeeq A.A. , Gbenga O.P. , Onimisi B.O. , Raji K.B. , Suleiman S. , Isaiah I.B. 
Published: July 2024

BACKGROUND AND AIM: Tramadol abuse has a substantial risk of altering the histoarchitecture and causing cognitive decline. Therefore, this study investigated the effects of tramadol on cognitive function and histopathological changes in the structures of the hippocampal formation.
METHODOLOGY: Twelve apparently healthy Wistar rats (120-150g) were used for this study. They were divided into two groups with six (n=6) rats in each group. The control group was given 2ml/kg of distilled water while 50 mg/kg of tramadol was given to group 2 orally for 21 days. The Morris Water Maze (MWM) was utilized to assess spatial learning and memory over the last six days of the experiment. The rats were euthanized and brains harvested, fixed in 10% formol saline, and processed routinely using haematoxylin & eosin (H&E) for general histoarchitecture.
RESULTS: The result of MWM showed a prolonged time taken and longer distance covered to locate the escape platform in the acquisition phase while the probe test showed less time spent in the target quadrant in which the platform was previously located in the tramadol-treated group. Histologically, there were several neuronal degenerative changes presenting as pyknotic nuclei, dark neurons, vacuolations, congested blood vessels, karyorrhexis, necrotic cells, and infiltration of cells in the various layers of the structures of the hippocampal formation.
CONCLUSION: Findings from this study revealed changes in spatial learning and memory, and hippocampal formation histopathology.
Peranan Komunikasi Interpersonal dan Religiusitas Remaja dalam Menghadapi Proseb Perceraian OrangTua
Authors: Imawati Rochimah 
Published: July 2024

Keluarga dalam proses perceraian berada dalam kondisi yang membutuhkan penyesuaian dan penerimaan yang cukup berat bagi pasangan, anak-anak, dan anggota keluarga lainnya. Penelitian kualitatif ini dalam pengumpulan data menggunakan wawancara dan observasi mendalam terhadap 5-orang subjek. Kasus perceraian pada penelitian ini terjadi setelah pernikahan berlangsung antara 15–22 tahun, dengan demikian respondennya adalah remaja berusia 17–21 tahun. Hasil penelitan menunjukkan bahwa komunikasi interpersonal antara orangtua (ibu) dengan anaknya dan dimensi religiusitas menjadi faktor yang cukup berperan menghadapi proses perceraian orangtua mereka, dan lebih siap pada kehidupan sebagai keluarga yang terpecah.
INGLIZ VA O‘ZBEK NASRIDA “O‘GAY ONA” OBRAZINING BADIIY TASVIRI
Authors: Nizomova Iroda 
Published: July 2024

Maqolada haqiqiy o‘zbek ayolining tasviri va ingliz adabiyotida tasvirlanadigan ona timsoli haqida izlanish olib borildi. Bugungi rivojlanayotgan davrda xalqimizning har bir sohada aholi savodxonligini oshirish zamonamizning eng muhim talablaridan biridir. Shuningdek, ushbu ilmiy maqolada o‘gay ona obrazining tarixiy va adabiy kontekstdagi rivojlanishi, o‘zbek va ingliz adabiyotida ushbu obrazning qabul qilinishi va evolyutsiyasi tahlil qilinadi; o‘gay ona obrazining o‘quvchilarga qanday tarbiyaviy va ijtimoiy ma’nolarni yetkazishi, uning ma'naviy xususiyatlari va jamiyatdagi o‘rnini ochib beriladi; bu obraz orqali adiblar qanday ijtimoiy muammolarni ko‘tarishi va ularni qanday yechimlarga yo‘naltirishi tahlil qilinadi; o‘gay ona obrazining psixologik xususiyatlari, uning ichki dunyosi, shaxsiy dramasi va ruhiy kechinmalari ko‘rib chiqiladi. Ingliz va o‘zbek nasrida o‘gay ona obrazining badiiy tasviri orqali har ikki millatning oilaviy qadriyatlari, ijtimoiy munosabatlari va tarbiyaviy yondashuvlari o‘ziga xos tarzda namoyon bo‘ladi. Tadqiqot natijalari adabiyotshunoslikka yangi qirralarni kiritib, o‘quvchilarning ushbu mavzuga nisbatan tushunchalarini kengaytirishga xizmat qiladi.
Determin Minat Beli Ulang Mie Gacoan Bekasi dengan Labelisasi Halal Sebagai Variabel Moderasi
Authors: Sarmila Lia , Listian Indriyani Achmad  , Ainulyaqin MH , Sakum  , Sukron Mamun  
Published: July 2024

This study aims to determine the effect of price and service quality service quality on repurchase interest in Gacoan Noodle products with halal labeling as a moderating variable. As a moderating variable. This research method uses SPSS 24 software with a sample of 100 respondents. Taken as many as 100 respondents. The data analysis method used is path analysis. The results showed that the value between price and Halal Labeling has a previous value (1.966) and a moderating value (1.966). Before (1.966) and has a value comparison (-2.978) then it can be concluded that the halal labeling variable is able to moderate the effect of the Price variable on the.Repurchase Interest variable. And the value between Service Quality and Halal Labeling has the previous value (0.513) and has a value comparison (0.426), so it can be concluded that the variable Halal labeling is not able to moderate the influence of the Service Quality variable on the Repurchase Interest variable.
تطبيق طريقة Make a Match لترقية قدرة التلاميذ على مهارة الكلام
Authors: Shelakumalasari  , Asyraf Muzaffar  , Danil  Zulhendra  
Published: July 2024

Based on the first observation made by researcher, many student of the 5 “A” class students at MIN 20 Aceh Besar, did not dare to speak Arabic in front of their teachers and friends because they were afraid of making mistakes when speaking. And in the Classroom, students are not enthusiastic about learning, because the teacher does not use various methods in learning Arabic, especially in learning speaking skills. To overcome this problem, researchers want to apply the Make a Match method to improve students’ speaking skills. This research aims to determine the effectiveness of applying the Make a Match method to improve students’ abilities in speaking skills and to determine the activities of theachers and student during the speaking skills learning process. The methodology of this research is an experimental approach with preliminary design. The researchers uses the (One Group Pre-test and Post-test Design). Researchers The researcher performs pre-test, post-test, and direct observation as a method of collecting data. The Result of this research is: (1) the application of the Make a Match method is effective in improving students’ ability to speak in MIN 20 Aceh Besar. It appears from the result of the T-Test at which shows a significance level (2-tailed) sig. 0,000, which is less than the result of the significance level of 0,005. This indicates that the alternative hypothesis (Ha) is accepted and the null hypothesis (Ho) is rejected. The teacher activities in applying the Make a Match method in teaching the speaking skill is very good. The Results of observing teacher activities were 92,5% with a very good grades. And the results of observing student activities were 90% with very good scores.
دور المدرسين لدوافع رغبة الطلبة في تعليم اللغة العربية
Authors: Banta Ali  
Published: July 2024

Teacher is one of human components in teaching and learning process that plays critical role in creating quality human resource for the development sector. In another definition, teacher is a person who teaches and performs studies focusing on applied activities by experimenting an idea into practice or real situations in a micro scale in which the activities are expected to develop and improve the quality of teaching and learning process within educational sector and to perform advancement in social sector. From another perspective, a teacher as the main principle in educational sector can predict a successful education for the future generations because the development and the prosperity of a nation is fostered through higher education.
Comparative evaluation of efficacy of Kulattha Gutika with Atorvastatin in the management of Dyslipidemia (Medoroga) - RCT
Authors: Nandal Praveen , Misar Wajpeyi Sadhana , Yadav Pankaj , Balpande Khushhali 
Published: July 2024

Introduction: Dyslipidemia is the disorder of lipoprotein metabolism manifested by an elevation of the total cholesterol, the low-density lipoprotein (LDL) cholesterol, the triglyceride concentrations, and a decrease in the high-density lipoprotein (HDL) cholesterol concentration in the blood. Today’s unhealthy food habits and sedentary lifestyle are the main causative factors for Dyslipidemia. It is not defined in Ayurveda, it can be related to a number of conditions, including "Medoroga, Rasa Raktagata Snehavruddhi Shonitabhishyandana, and Dhamanipratichaya" based on similarities in etiology, pathogenesis, and manifestations. Aim: Comparative evaluation of Efficacy of Kulattha Gutika and Atorvastatin in the Management of Dyslipidemia (Medoroga). Material and Methods: Study comprises total 60 patients of Dyslipidemia randomly divided into two equal groups. Group A (Experimental group) was treated with 1gm Kulattha Gutika thrice a day before meals with warm water and Group B (Control group) was treated with 10 mg Atorvastatin at night before sleep with water for 45 days. Patients were assessed for Objective parameters like Lipid profile (S. TCH, TG, LDL, HDL, VLDL) and BMI was done on 0 and 45th day. Result: Statistically significant improvement was observed in objective parameters like TCH, HDL, LDL, VLDL, and TG in both groups. But in BMI Statistically significant improvement was observed in group A, treated with Kulattha Gutika. Conclusion: Kulattha Gutika is as efficacious as Atorvastatin in managing Dyslipidemia (Medoroga) and is an economical alternative without adverse effects.
Development and validation of a tool to assess Rukshatha in healthy individual
Authors: C Ragesh , KB Sudhikumar 
Published: July 2024

In Ayurveda Ruksha (Dry) Guna (Property)which is one among Gurvadi Guna(Biological qualities) cause dryness. The property of Ruksha Guna (Dry property) is increaseVata and normalizes Kapha and also decreases body Strength and normal colour of body. The main objective of study is to find out tool for assessing Ruksha guna in healthy individual. Based on theoretical reference, FGD and IDI conducted among experts 35 items are generated in two domains (Physical and Psychological). From this 29 items are selected for final administration on selected sample for validity and reliability assessment. Each item is scored using 4 point Likert scale -no, rarely, often, every time with scoring 0, 1, 2, 3 respectively. Subjective question assessed by interrogation and objective parameter dryness of body parts are also assessed by this scoring method. Total 100 samples are selected for final administration of sample. The tool with 29 items gave a Cronbach’s Alpha 0.745 (n=29) showing high construct validity and internal consistency. After the reliability and validity assessment 1 items deleted from the administered tool in the selected sample. Finally there are 28 items are included in the Ruksha Guna assessment tool.
Role of Ayurveda in Enhancement of Mobility and Muscle Strength of the Elderly – A Review
Authors: Kaushik Jyoti 
Published: July 2024

Introduction: Aging is associated with several diseases, which are mainly due to the depletion of physiological reserves and the weakening of the immune mechanism. People’s quality of life is reduced by many health problems such as pain, fatigue, and mobility impairments. Decreased mobility and decreased muscle strength end up with multiple medications without complete treatment, leading to the deterioration of a person’s physical and mental health. Ayurveda primarily focuses on maintaining general health by preventing the entry of disease-causing substances to keep a person healthy. India is only the second country with the largest elderly population in the world after China. Ayurveda offers a wide range of preventive measures to combat the aging process. It has a focused branch called Rasayana, Panchakarma therapy which mostly treats geriatric problems. Various Panchakarma therapies, such as Abhayanga, Shastika Shali Pinda Sweda, Janu Basti, and Kati Basti aim to improve a person’s mobility and muscle strength. In spite, of this regular Yoga and Pranayama, Lifestyle modifications can help improve muscle strength in old age. Aim: The aim of the study is to find out Ayurvedic principles significant in the enhancement of mobility and muscle strength in old age peoples. Material and Methods: Systematic data from various journals, text books, and published articles are collected. Conclusion: Ayurvedic therapies, such as panchakarma and rasayana chikitsa, and lifestyle modifications, work synergistically to improve physical functions and vitality. Integrating Ayurveda with conventional geriatric care provides a comprehensive strategy to address the multifaceted challenges of aging.
Working Together on Civil-Engineering Structures within the Dutch Flood Protection Programme: challenges and opportunities
Authors: Tromp Ellen , Breedeveld Joost , Apperloo Johan , Kottier Jaap 
Published: July 2024

Abstract. Over 400 civil-engineering structures (e.g. sluices, pumping stations) are listed in the Dutch Flood Protection Programme (DFPP). That is a daunting task for the next 30 years, meaning that every three weeks one structure should be reinforced to meet the statutory standards. In an innovation project, the regional water authorities, Rijkswaterstaat, the Dutch Flood Protection Programme, research institutes and the consultancy agencies joint forces. In the past period, we have identified numerous obstacles, using the critical success factors framework, that hamper the reinforcement of these civil engineering structures. To tackle the barriers, we developed a roadmap that gives more insight in the steps for strengthening these structures. In addition, lessons learned from current strengthening projects on civil engineering structures are used to further optimize the overall programming of these structures within DFPP, and to enhance the knowledge transfer and uptake within the triple helix.
IMPLEMENTASI PROGRAM BANTUAN RUMAH LAYAK HUNI KEPADA MASYARAKAT KURANG MAMPU TAHUN 2019 - 2023 (Studi Di Desa Gunung Sari Kecamatan Bonegunu Kabupaten Buton Utara)
Authors: Sulandari  , Ambo Upe  , Aryuni Salpiana Jabar  
Published: July 2024

Penelitian ini bertujuan untuk : (1) Untuk menjelaskan implementasi program rumah bantuan dalam memahami rumah layak huni di Desa Gunung Sari Kecamatan Bonegunu Kabupaten Buton Utara. (2) untuk mengetahui perubahan kondisi kebutuhan perumahan pada masyarakat kurang mampu di Desa Gunung Sari Kecamatan Bonogunu Kabupaten Buton Utara. Metode penelitian yang dilakukan adalah penelitian kualitatif. Penelitian ini menggunakan pendekatan kualitatif dengan informan berjumlah sebanyak 13 orang dipilih dengan teknik purposive. Data dalam penelitian ini di peroleh melalui observasi, wawancara dan studi dokumentasi. Data yang di peroleh kemudian di analisis secara kulitatif dengan model interaktif yang terdiri dari reduksi data, penyajian data, dan penerikan kesimpulan. Hasil penelitian menunjukkan bahwa 1) Implementasi program rumah bantuan berdasarkan sumber dananya berdasarkan sumber dana desa. Keteria masyarakat penerima program yaitu kelurga yang tidak mampu, berstatus tempat tinggal menumpang, memiliki KTP dan KK, digunakan oleh Tim Survey Desa, dan di serujui oleh Tim Survey Kecamatan; dan 2) Perubahan kondisi kebutuhan perumahan pada masyarakat kurang mampu di Desa Gunung Sari Kecamatan Bonogunu Kabupaten Buton Utara Selanjutnya Implementasi pada program bantuan rumah tidak layak huni di Desa Gunung Sari berdasarkan hasil penelitian telah mencapai tujuan program yang diharapkan, yaitu tersedianya hunian yang layak bagi masyarakat berumah tidak layak huni, Penilaian kelayakan hunian dengan melihat pada penilaian empat indikator rumah layak huni yang dikemukakan oleh Badan Pusat Statistik tahun 2019 yaitu kecukupan luas tempat tinggal, akses air minum layak, akses sanitasi layak serta penilaian terhadap ketahanan bangunan yang meliputi atap, dinding dan lantai rumah
PRODUCTION OF LITHIUM CARBONATE FROM SPODUMENE CONCENTRATE OF KOLMOZERSKOYE DEPOSIT AND ITS USE IN SYNTHESIS OF SOLID ELECTROLYTE
Authors: Касиков А.Г. , Щелокова Е.А. , Куншина Г.Б. , Бочарова И.В. , Кузнецов И.А. 
Published: July 2024

Представлены результаты по получению карбоната лития из очищенных от Al, Fe, Mg и Ca растворов от сернокислотного выщелачивания b-сподумена Колмозерского месторождения. Исследован процесс синтеза порошков твердых электролитов со структурой NASICON состава Li₁․₃Al₀․₃3Ti₁․₇(PO₄ )₃(LATP) с использованием Li₂СO₃, полученного в результате переработки сподуменового концентрата.
Preparation of lithium carbonate from spodumene concentrate of the Kolmozersky deposit and its use in the synthesis of solid electrolyte. The results on the preparation of lithium carbonate from solutions purified from Al, Fe, Mg and Ca from sulfuric acid leaching of b-spodumene of Kolmozerskoye deposit were presented. The process of synthesis of solid electrolyte powders with NASICON structure of composition Li₁․₃Al₀․₃3Ti₁․₇(PO₄ )₃(LATP) using Li₂СO₃ obtained from spodumene concentrate processing was investigated.
Correlation of Urinary Gamma Glutamyl Transferase to Creatinine Ratio with Albumin Creatinine Ratio in Patients with Type 2 Diabetes Mellitus
Authors: Shazia Hameed  , Khan Mahnoor , Ustrana Shahjahan 
Published: July 2024

Background: Diabetic Nephropathy is one of the most serious outcomes of Diabetes Mellitus worldwide. As tubular injury precedes albuminuria, tubular enzyme Gamma Glutamyl Transferase (GGT) may serve as a more sensitive diagnostic biomarker for diabetic nephropathy.
Objective: To determine and correlate urinary Gamma Glutamyl Transferase to creatinine ratio with urinary albumin creatinine ratio (uACR) in Type 2 diabetics based on gender.
Methods: A cross-sectional study was undertaken at Shaikh Zayed Hospital from March 2022 to April 2023. A total of 100 male and female participants were included in this study. The study participants included 75 type 2 diabetics and 25 controls. The diabetic group was subdivided into normoalbuminuric and microalbuminuric based on urinary albumin creatinine ratio. All subjects' fasting blood glucose, urinary albumin, urinary creatinine, and urinary GGT levels were measured on the automated chemistry analyzer. The data was analyzed by SPSS version 24. “t-test” was used to compare the variables between different groups. The Pearson correlation test was used to establish the correlation between Gamma Glutamyl Transferase to creatinine ratio and uACR.
Results: Urinary GGT (uGGT) levels were significantly higher in all type 2 diabetics as compared to controls (p <0.001). Both urinary albumin and uACR were raised in male diabetics (p<0.001) and female diabetics (p<0.005) as compared to controls, in male diabetics more increase was observed (p<0.001). A highly significant positive correlation was observed between uGGT:Creatinine ratio and uACR of all normoalbuminuric patients (‘r’ males=0.837 & females=0.919) and microalbuminuric patients (‘r’ males=0.600 & females=0.636) at p<0.001.
Conclusion: Urinary Gamma Glutamyl Transferase to creatinine ratio is positively correlated with urinary albumin creatinine ratio and may serve as a more sensitive biomarker than urinary albumin creatinine ratio in diabetic patients with renal damage.
Functional Visual Outcomes of Wearing Colored Filters in Patients with Dry Age-Related Macular Degeneration
Authors: Syeda Baneen Jannat  , Shaheer Muhammad , Asima Rafique  
Published: July 2024

Background: Age-related macular degeneration (AMD) leads to a permanent decrease in vision, thus affecting the quality of life. Any intervention or modality that enhances the quality of vision and, in turn, quality of life is vital.
Objective: To evaluate the functional benefits of wearing colored filters in patients with dry age-related macular degeneration.
Methods: The study was conducted from March to October 2023 after approval by the Ethical Review Board. Thirty-one patients above 50 years of age diagnosed with dry AMD at Mayo Hospital, Lahore, Pakistan, were selected using a non-probability convenient sampling technique. After informed consent, different color filters were placed in the patient’s glasses according to their compliance. Each eye was tested separately for contrast sensitivity (CS) and best-corrected visual acuity (BCVA) before and two weeks after the filter placement. Contrast sensitivity was assessed using the Lea contrast Flip chart, and BCVA was assessed using the LogMar chart. A paired sample t-test was applied for data analysis. A p value of less than 0.05 was considered as statistically significant.
Results: Best corrected visual acuity in the right and left eye improved significantly from 1.00±0.41 to 0.72±0.25 (p=0.000) and from 0.96±0.43 to 0.72±0.30 (p=0.000), respectively after applying filters. However, changes in contrast sensitivity were not significant in the right eye (p=0.59) and left eye (p=0.39).
Conclusion: Using colored filters significantly improves the best corrected visual acuity, with no contrast sensitivity improvement. This shows that filters selectively impact functional vision in patients with dry age-related macular degeneration.
ORIGINAL SIN DALAM PERSPEKTIF KRISTEN: SUATU KAJIAN TEOLOGIS DAN ETIS
Authors: Bengu Renny Tade 
Published: July 2024

Studi ini mendalami konsep dosa asal dalam perspektif teologis dan etis Kristen, menyajikan analisis yang komprehensif tentang implikasi teologis dan praktisnya. Dengan menyajikan latar belakang historis dan teologis, menyoroti relevansi topik ini dalam konteks Kristen kontemporer. Metodologi penelitian melibatkan pendekatan teologis yang mencakup analisis Alkitab, pemikiran teologis, dan kajian literatur terkait. Dengan mengulas secara mendalam universalitas dosa, refleksi terhadap pandangan yang menolak dosa asal, dan hubungan antara dosa asal dengan kerusakan total manusia serta implikasinya dalam konteks dosa aktual. Studi ini juga menelusuri akibat dosa dan signifikansi salib Kristus dalam penebusan manusia dari dosa. Penelitian ini menyoroti temuan kunci, menawarkan refleksi teologis, dan merangkum implikasi etis dalam kerangka pemahaman Kristen tentang dosa. Dengan menyatukan pendekatan teologis dan etis, penelitian ini memberikan kontribusi penting bagi pemahaman tentang dosa asal dalam teologi Kristen kontemporer.