bluuebunny/crossref_metadata_2025_split huggingface dataset:
Id Proteins Contribute to Tumor Development and Metastatic Colonization in a Model of Bladder Carcinogenesis
Authors: Garcia-Cao Marta , Al-Ahmadie Hikmat A. , Chin Yvette , Bochner Bernard H. , Benezra Robert 
Published: October 2015

Background: Bladder cancer is one of the most common malignant genitourinary diseases worldwide. Despite advances in surgical technique, medical oncology and radiation therapy, cure of invasive tumors remains elusive for patients with late stage disease. Therefore, new therapeutic strategies are needed to improve the response rates with regard to recurrence, invasion and metastasis. Objective: Inhibitor of DNA binding (Id) proteins have been proposed as therapeutic targets due to the key regulatory role they exert in multiple steps of cancer. We aimed to explore the role of Id proteins in bladder cancer development and the pattern of expression of Id proteins in bladder carcinomas. Methods: We used a well-established chemically induced model of bladder carcinogenesis. Wild type and Id-deficient mice were given N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in the drinking water and urinary bladder lesions were analyzed histopathologically and stained for Id1. We assessed the effects of Id1 inactivation in cultured bladder cancer cells and in a model of metastatic lung colonization. We also performed Id1 staining of human urothelial carcinoma samples and matched lymph node metastases. Results: Id1 protein was overexpressed in the BBN-induced model of bladder cancer. Id1 deficiency resulted in the development of urinary bladder tumors with areas of extensive hemorrhage and decreased invasiveness when compared to wild type mice. Id1 inactivation led to decreased cell growth in vitro and lung colonization in vivo of human bladder cancer cells. Immunohistochemistry performed on human urothelial carcinoma samples showed Id1 positive staining in both primary tumors and lymph node metastases. Conclusions: In summary, our studies reveal the physiological relevance of Id1 in bladder cancer progression and suggest that targeting Id1 may be important in the development of novel therapies for the treatment of bladder cancer.
Treatment Decision Making in Patients with Bladder Cancer
Authors: Berry Donna L. , Nayak Manan , Halpenny Barbara , Harrington Shannon , Loughlin Kevin R. , Chang Peter , Rosenberg Jonathan E. , Kibel Adam S. 
Published: October 2015

Background: Each stage of bladder cancer involves varying treatment issues and concerns that are discussed between patients and providers during the pre-treatment consultation. There is no documentation of how patients engage in decision making. Objective: To describe aspects of treatment decision making perceived by patients with bladder cancer using qualitative analysis of data from individual interviews. Methods: Patients with any stage bladder cancer were recruited from urology and medical oncology services at a comprehensive cancer center. A qualitative approach to data collection and analysis was applied. Individual, semi-structured interviews were conducted, recorded and transcribed. Coding of the transcripts was conducted by research team members, discussed for consensus and major themes derived. Results: 45 men and 15 women, the majority college educated, were recruited. Where to receive care, including from whom, was the initial and major decision. Challenges of decisions regarding urinary reconstruction were dominant. Personal characteristics, including age and being active, were considered. Participants with early stage tumors ( n = 28) typically perceived only one treatment option and followed the physician’s recommendation. The 18 participants with stage II-III were aware of multiple options. In 14 stage IV participants, balancing quality of life and outcomes between treatments was common to the decision process. Conclusions: For this educated sample with bladder cancer, recruited at a comprehensive cancer center, the major decision was to seek treatment at a location with the highest level of physician expertise. Personal preferences informed decisions surrounding bladder reconstruction. Further research will be conducted in a diverse sample of patients making decisions in a non-urban, community setting.
Femmes en temps de guerre. Pétrifications et réserve figurative de l’hystérie.
Authors: Abdelouahed Houria 
Published: October 2015

Se saisissant du cas d’une femme irakienne victime de viol, l’auteure explique les raisons de son désaccord avec une application de l’histoire d’Amphitryon (où le jeu du désir et du plaisir va de pair avec le leurre) sur la violence qu’impose le violeur à la psyché et au corps de sa victime. Le terme arabe qui désigne le viol (ightisâb) signifie littéralement la néantisation de la psyché. Ce dernier, sorte de matricide déplacé, engendre une éradication subjective, des expériences agonistiques, souffrances narcissiques, psychoses post-traumatiques… À la lumière de cette clinique, l’auteure révise la notion de traumatisme telle qu’elle figure dans les théorisations de René Roussillon, et rappelle que la plupart des travaux psychanalytiques envisagent le crime du point de vue du criminel : fascination pour le criminel, l’échec du narcissisme, le lien avec le perceptif, la sensori-motricité, la cruauté de mort… Face à un vécu de sidération, l’analyste fait appel, dans l’après-coup, à la réserve des ressources imaginatives et figuratives de l’hystérie pour pouvoir associer et psychiser. Les ressources de l’hystérie sont nécessaires dans cette clinique de l’extrême.
Mal de mère : la « vraie » femme
Authors: Kessaci Lyasmine 
Published: October 2015

La maternité est-elle le parachèvement logique et l’aboutissement nécessaire de la féminité ? Si l’on considère que le désir d’enfant se substitue au désir du phallus, au « Penisneid », et que le désir d’être mère tente de répondre à ce qui s’est joué dans le rapport (ravageant) de la femme à sa propre mère, il semble effectivement difficile de penser la féminité sans la maternité. Mais que l’on considère aussi que l’advenue d’un enfant dans le réel ne corresponde pas forcément à la réponse que ces désirs appelaient, et que les situations pathologiques démontrant toute l’ambivalence des mères vis-à-vis de leurs enfants sont loin d’être rares (certaines pouvant même s’avérer extrêmes), et l’on admettra alors que c’est plutôt sur le mode de l’opposition radicale que féminité et maternité s’articulent parfois. Ce que le mythe de Médée – la « vraie femme », selon Lacan – laissait déjà entendre : en tuant ses enfants, c’était aussi la mère en elle qu’elle tuait, pour ne plus laisser place qu’à la seule femme.
La mélancolie féminine aux origines de la maternité
Authors: Brun Danièle 
Published: October 2015

C’est la lecture d’une lettre que Freud écrivit à Stefan Zweig en 1932 qui me mena à découvrir une autre façon d’être mère que j’appelle : Mère majuscule. Il s’agit d’une production de l’inconscient qui trouve sa source dans les relations précoces de la petite fille avec sa mère. Cela se traduit dans la vie quotidienne par un état mélancoliforme que fait surgir la prise de conscience d’un écart entre la représentation de l’enfant de chair, l’enfant réel et celle de l’enfant fantasmé depuis la prime enfance. Une intrication anatomo-psychique caractéristique de la féminité, telle qu’abordée par Freud dans les années 1930.
Le genre serait une névrose
Authors: Lesourd Serge 
Published: October 2015

Comme le montrent les mythes fondateurs de Dionysos et de la Vierge, ce qui constitue le sujet, c’est la séparation entre jouissance maternelle et jouissance de la femme. Cette séparation radicale doit être soutenue par le lien social, ce qu’avait fait pendant des siècles la fiction paternelle avec ses avatars phallocratiques de la « domination masculine » et la production des névroses classiques. Les théories des genres semblent venir remplacer ces constructions dans un monde où règne la loi des Maîtres invisibles et du discours du Capitaliste, faisant du genre une forme actuelle des névroses.
L’abolition du passé et le tabou du féminin. Une lecture de Sa Majesté des mouches de William Golding
Authors: Cohen-Salmon Julie 
Published: October 2015

Sa Majesté des mouches de William Golding est un roman qui met en scène la montée d’une violence sacrificielle chez un groupe d’enfants âgés de 6 à 12 ans, échoués sur une île sauvage. Par la nécessité de s’adapter à leur nouvel environnement extérieur, certaines ressources psychiques sont mobilisées. Les enfants survivants vont se détacher de leur vie d’avant le naufrage, se mettant à distance de leurs souvenirs. À côté de cet éloignement nous soulignons l’absence de filles dans le récit. En quoi l’abolition du passé et ce qui se révèle être un tabou du féminin seraient au fondement d’une violence sacrificielle ?
Le lien mère-enfant à l’épreuve des violences conjugales
Authors: Metz Claire , Thévenot Anne 
Published: October 2015

Les enfants témoins de violence conjugale constituent une population à risque encore trop souvent méconnue en France. Pourtant, l’ampleur et la gravité de ces violences nous alertent quant aux conséquences actuelles et futures sur les enfants. Les travaux issus d’Amérique du Nord insistent surtout sur les symptômes visibles des enfants et sur les risques de répétitions transgénérationnelles des violences, sans explorer les mécanismes psychiques en jeu. Or, ces mécanismes peuvent expliquer en partie pourquoi ces violences sont si difficiles à enrayer dans nos sociétés, où nous constatons leur persistance malgré les dispositifs de traitement et de prévention. Nous proposons donc d’élucider quelques enjeux psychiques chez l’enfant témoin et sa mère, qui peuvent expliquer et permettre de mieux prévenir ces phénomènes de répétition. Ainsi, deux illustrations cliniques révèlent la fragilité fondamentale du « Moi-peau » de ces enfants et les difficultés de leurs mères, montrant la nécessité d’accompagner le lien mère-enfant.
Clinique des psychoses infantiles : du transfert dissocié à la direction de cure
Authors: Pouillaude Élie 
Published: October 2015

Centré sur la clinique des psychoses, l’auteur propose de présenter les modalités théorico-cliniques à partir desquelles l’association de santé mentale La Nouvelle Forge organise sa pratique actuelle du traitement des patients dissociés. Il sera question de soutenir le concept de « direction de cure » autour duquel est articulée cette clinique psychanalytique et institutionnelle des enfants et adolescents psychotiques, en réponse aux caractéristiques psychiques et transférentielles de leur fonctionnement psychopathologique. Cette pratique sera étayée par la présentation de la cure du jeune Sylvain.
Sevrage alcoolique et pulsion de mort : clinique du vide
Authors: Delostal Chloé , Sanahuja Maria de la Almudena 
Published: October 2015

Ce présent article a pour objectif de développer les difficultés rencontrées à l’abord de la problématique alcoolique et au sein de la relation avec le patient alcoolo-dépendant en processus de sevrage. À travers le discours alexithymique et apsychognosique, et les contre-attitudes ou contre-transferts du clinicien face au patient, nous constatons que le déni et la pulsion de mort agissent chez l’un comme chez l’autre et viennent entraver la relation thérapeutique, qui devient alors manquée. La vignette clinique nous permettra d’illustrer la prégnance de la pulsion de mort au sein de cette problématique, et les difficultés thérapeutiques à aborder le déni, pathognomonique, dans cette relation. Cet article se propose de confirmer la complexité de la rencontre alcoolique et de ses enjeux thérapeutiques singuliers, impliquant la prise en compte, dans cette rencontre de sevrage, de ce que nous appellerons la « clinique du vide » ou « clinique du négatif ».
Corps handicapé, culture et norme. Penser le handicap en dehors du modèle exclusion/intégration
Authors: Squverer Amos 
Published: October 2015

L’auteur chercher à éclairer l’articulation entre culture et handicap en la comprenant comme structurellement conflictuelle. Cette tension structurelle s’éclaire à partir de l’opérateur freudien du désaide. La situation du handicap, en tant qu’elle renvoie à l’état de désaide, angoisse le social et pointe son impuissance. Cette tension entre culture et handicap s’éclaire également par le nouage serré entre la norme et le corps que le corps handicapé vient troubler. L’auteur cherche à saisir le fondement de ce nouage entre corps et norme et soutient que la pensée normative a comme point d’origine le corps. Enfin, si la culture maintient un rapport oppressant (exclusion) ou normatif (intégration) avec le handicap, depuis quand ce rapport s’est-il cristallisé, et comment peut-on sortir de cette dichotomie ? L’auteur revisite, dans un deuxième temps, les rapports à l’infirmité dans le discours religieux – matrice de ce traitement social du handicap – pour répondre à ces questions.
Wettability Alteration of Heavy-Oil/Bitumen Containing Carbonates Using Solvents, high pH Solutions and Nano/Ionic Liquids
Authors: Cao Nahai , Mohammed M. Almojtaba , Babadagli Tayfun 
Published: October 2015

Abstract
Capillary imbibition tests are commonly applied to measure wettability alteration potential of chemicals. However, these tests are exhaustive, time-consuming, expensive, and the underlying physics of the alteration process from a surface chemistry point of view is often limited and/or unexplained. Contact angle measurement is a quicker and more feasible screening tool to assess the emerging wettability modifiers. They also provide visual data on the mechanics of the wettability alteration process. This paper focuses on contact angle measurements as a mean to evaluate the wettability alteration on mineral plates and porous rock samples. Imidazolium ionic liquids were tested at different concentrations. To study the effect of pH on the wettability, sodium chloride and sodium borate were used at different concentrations. The composition of divalent ions was varied due to their possible use with low/high salinity water as wettability alteration agent. Unmodified and surface modified silica, zirconium, and alumina nanoparticles were also tested.
Contact angle measurements were performed initially on mica, marble, and calcite plates. Experiments were repeated on polished surfaces of Berea sandstone, Indiana limestone, and -cleaned- Grosmont carbonate cores. Oils (pure and solvent mixed crude oils) with different viscosities and densities were used to test the effect of oil type on the process. The images were obtained by an SLR camera at different temperatures ranging from 25 to 80°C. By testing with different concentrations, the optimum chemicals were found for different mineral plates/porous rock systems. Then, the results were cross-checked with the imbibition tests performed on the same samples to validate the contact angle measurement observations.
Thermal stability tests were also performed in case of their use during or after a thermal method. For the thermal stability tests, contact angle experiments were conducted in a high pressure and high temperature (up to 200°C) cell. It was shown that certain ionic liquids and nanofluids are stable at high temperatures and can be efficiently used at low concentrations.
BC-10 Subsea Production System Integrated Approach
Authors: Delescen K. , Nicholson M. , Olijnik L. , Ortiz W. , Maia A. , Lacourt R. , Nunes H. 
Published: October 2015

The Parque das Conchas (BC-10) project consists of five fields, Ostra, Abalone, Argonauta B-West, Argonauta O-North and Nautilus, located in the Campos Basin area, offshore Espirito Santo, Brazil. The project is situated 75 miles (120 kilometers) southeast of the city of Vitoria, in water depths of 4,921 to 6,562 feet (1,500 to 2,000 meters).
During the development of Phase II and III, Shell adopted an innovative integrated approach for the delivery, testing, installation and commissioning of the Subsea Production System. This approach led to significant gains in operational efficiency and overall helped in the optimization of the rig schedule.
Some of the critical elements for success of the Project were the alignment of hardware delivery with logistics and custom clearance activities, a fit-for-purpose test facility in Vila Velha, a dedicated Multi Purpose Supply Vessel together with its ROV services, and a dedicated multidisciplinary team which leveraged the optimization of the learning curve through the execution of the project.
17 Tubing Head Spools (THS) and 17 Subsea Trees were successfully installed in water depths up to 1850 m. by Multi-Purpose Support Vessel (MPSV) Holiday in 2 separate campaigns that spanned roughly 2 years.
The MPSV with its 150 T Active Heave Compensated (AHC) Crane showed excellent performance in executing its core hardware installation activities, and was then also used on multiple additional Inspection, Maintenance and Repair (IMR) jobs, optimizing the utilization for the specific field development. Most relevant among this peripheral work were: data acquisition from a permanent seabed seismic array, support in a Gas Export line remediation project and repair of a service line jumper.
Additionally, for the 7 trees of Phase III, the vessel ROVs participated in commissioning activities, communicating with the tree control system, to anticipate cycling and opening of the downhole isolation valves, resulting in further savings of rig days. For this purpose a project specific ROV kit was arranged to communicate with the tree control pod, provide fail safe double barriers during the intervention, and inject conditioning fluids inside the shallow section of the well bore.
This paper will detail the integrated approach taken for this field development, the added value unlocked with this approach, and will point out the efficiency gains obtained.
Step-Change Seabed ESP Boosting
Authors: Homstvedt G. , Pessoa R. , Portman L. , Wang S. , Gonzalez J. , Maldaner M. , Margulis J. 
Published: October 2015

Electrical Submersible Pump (ESP) systems have been applied successfully for seabed hydrocarbon boosting for years. However, the design of ESPs for in-well applications presents several limitations for its use on the seafloor. The long slender body and limited gas handling capabilities have historically been important factors restricting the wider use of ESPs in subsea applications. In order to overcome the main design challenges, ESPs have been placed in caissons that enable gas/liquid separation and installation of the pump in a vertical position. This arrangement has resulted in high installation and work-over costs, limiting the acceptance in subsea applications. For low gas applications, skid based subsea ESP designs have also recently emerged, but these are large and heavy, which also leads to higher installation and work-over costs.
The Subsea Production Alliance between Baker Hughes and Aker Solutions has developed an innovative new solution to these challenges in the form of an ESP system installed in a flow line jumper. This new solution utilizes the same well proven ESP and increases its gas tolerance by utilizing state-of-the art technology used in subsea separation and boosting applications. Fluid conditioning, gas/liquid mixing and liquid recirculation together with field proven control algorithms form the revolutionary flowline booster system. Installation and retrieval of the jumper-mounted ESPs are as simple as retrieving a standard flowline jumper by using a light installation vessel and field proven tie-in technology. This new system provides for a step-change in operational robustness and cost-benefit for subsea boosting solutions.
This paper presents the concept and highlights the benefits of modularity, ease of installation and replacement, operability and client value. A simulation of the operational performance of the system applied in a brown field application is presented. A commercial comparison between the flowline booster system and a skid based ESP boosting system is also presented.
Coarse-Grained Models for Crude Oils: A Direct Link Between Equations of State and Molecular Simulations
Authors: Müller E. A. , Herdes C. , Totton T. S. 
Published: October 2015

A description of fluid systems with molecular-based algebraic equations of state (EoS) is common practice in the oil industry while direct molecular simulation is a mainstream tool in the physical sciences, but the two approaches are rarely closely coupled. We describe a framework whereby we link molecular simulations to continuum EoS, effectively bridging large size and time scales. The novelty in our approach is that the EoS is employed to develop a force-field model for the intermolecular interactions (i.e., a potential energy function that can be used directly in microscopic/molecular simulations of fluids). This multi-scale model has the advantage that molecular simulations performed using said force field may be employed to explore aspects of the fluid properties that are inaccessible to experiment (owing to limitations resulting from the resolution of the system size, the short timescale, or extremes in the experimental conditions) and/or to theory (e.g., an accurate description of the structural/microstructural or dynamical properties of dense fluids)The procedure is exemplified by describing a coarse grained model for the simulation of a light condensate and a heavier live crude oil. By fitting the SAFT EoS to experimental pure component properties (densities, vapor pressures), one is able to obtain parameters for all the constituents in the mixture including surrogate models for the heavy ends. We employ this SAFT model to predict the phase behavior of synthetic mixtures of crude oils composed of discrete components by means of direct multiphase molecular dynamics.As proof-of-concepts, the dew point of a synthetic seven-component mixture is predicted from molecular dynamics simulations without the need of any fitted parameter and is in excellent agreement with experimental data. Similarly, the largest reported simulation, equivalent to over one million atoms, of a 15-component crude oil mixture including a model resin and asphaltene, is described. The framework presented is completely generic in nature and a discussion on the way it can be adapted for the study of complex mixtures including surfactants, aqueous systems, systems containing precipitants such as asphaltenes or waxes in a relatively straightforward way is given.