bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated plasma protein carbonylation increases the risk of ischemic cerebrovascular events in patients with atrial fibrillation: association with a prothrombotic state
Authors: Nowak Karol , Zabczyk Michal , Natorska Joanna , Zalewski Jaroslaw , Undas Anetta 
Published: July 2024

Abstract
Introduction
Plasma protein carbonylation that reflects oxidative stress has been demonstrated to be associated with the prothrombotic fibrin clot phenotype. However, the role of protein carbonyls (PC) in predicting ischemic stroke in atrial fibrillation (AF) is largely unknown. This study aimed to investigate whether PC increase the risk of stroke in anticoagulated AF patients during follow-up.

Methods
In 243 AF patients on anticoagulation (median age 69 years; median CHA2DS2-VASc of 4), we measured plasma PC using the assay by Becatti, along with plasma clot permeability (Ks), clot lysis time (CLT), thrombin generation, and fibrinolytic proteins, including plasminogen activator inhibitor type 1 (PAI-1) and thrombin activatable fibrinolysis inhibitor (TAFI). Ischemic stroke, major bleeding, and mortality were recorded during a median follow-up of 53 months.

Results
Plasma PC levels (median, 3.16 [2.54–3.99] nM/mg protein) at baseline showed positive associations with age (P < 0.001), CHA2DS2-VASc (P = 0.003), and N-terminal B-type natriuretic peptide (P = 0.001), but not with type of AF or comorbidities except for heart failure (P = 0.007). PC levels were correlated with CLT (r = 0.342, P < 0.001), endogenous thrombin potential (r = 0.217, P = 0.001) and weakly with Ks (r = -0.145, P = 0.024), but not with fibrinogen, PAI-1, or TAFI levels. Stroke was recorded in 20 patients (1.9%/year), who had at baseline 36% higher PC levels (P < 0.001). Elevated PC (P = 0.003) at baseline were independently associated with stroke risk.

Conclusion
Our findings suggest that in patients with AF enhanced protein carbonylation is associated with increased “residual” risk of stroke despite anticoagulation, which is at least in part due to unfavorably altered fibrin clot phenotype.

Graphical Abstract
Exopolysaccharides from Limosilactobacillus reuteri: their influence on in vitro activation of porcine monocyte-derived dendritic cells - brief report
Authors: Kiššová Zuzana , Schusterová Petra , Mudroňová Dagmar , Novotný Jaroslav , Tkáčiková Ľudmila 
Published: July 2024

AbstractThe aim of this study was to evaluate the immunomodulatory potential of two α-D-glucans from Limosilactobacillus reuteri L26 Biocenol™ (EPS-L26) and L. reuteri DSM17938 (EPS-DSM17938), with respect to their influence on in vitro activation of porcine dendritic cells (DCs). We used immature DCs differentiated from porcine blood monocytes under in vitro conditions. Based on the surface expression of MHC II and costimulatory CD80/86 molecules, we showed that both used EPSs favour the maturation of monocyte-derived DCs (MoDCs) similarly to the commonly used stimulant tumour necrosis factor α (TNF-α). In contrast to TNF-α stimulation, MoDCs treated with both used EPSs significantly up-regulated the mRNA levels not only for interleukin (IL)-10 (P < 0.0001 for EPS-DSM17938; P = 0.0037 for EPS-L26), but also for IL-12 (P = 0.0176 for EPS-DSM17938; P = 0.0019 for EPS-L26). These cytokines are known to regulate T-cell kinetics and play a key role in maintaining immune homeostasis. Interestingly, only relatively linear α-D-glucan (EPS-DSM17938) significantly increased gene expression of the major pro-inflammatory cytokine IL-1β (P = 0.0011) and the “SOS” cytokine IL-6 (P = 0.0127). However, it is important to highlight the need for further studies aimed at cytokine kinetics in DCs, as well as a co-culture study with allogenic T-lymphocytes.
A Systematic Review and Characterization of the Major and Most Studied Urban Soil Threats in the European Union
Authors: Binner Hannah , Wojda Piotr , Yunta Felipe , Breure Timo , Schievano Andrea , Massaro Emanuele , Jones Arwyn , Newell Jennifer , Paradelo Remigio , Popescu Boajă Iustina , Baltrėnaitė-Gedienė Edita , Tuttolomondo Teresa , Iacuzzi Nicolò , Bondi Giulia , Zupanc Vesna , Mamy Laure , Pacini Lorenza , De Feudis Mauro , Cardelli Valeria , Kicińska Alicja , Stock Michael J. , Liu Hongdou , Demiraj Erdona , Schillaci Calogero 
Published: July 2024

AbstractThere is an urgent need by the European Union to establish baseline levels for many widespread pollutants and to set out specific levels for these under the Zero pollution action plan. To date, few systematic reviews, superseded by bibliometric analyses, have explored this issue. Even less research has been carried out to compare the efficacy of these two data extraction approaches. This study aims to address these two issues by i) constructing an inventory of the available information on urban soils, highlighting evidence gaps and measuring compliance with the Zero pollution action plan, and by ii) comparing the methods and results of these two data extraction approaches. Through Scopus and Web of Science databases, peer-reviewed articles using the terms urban soil in combination with specific urban soil threats and/or challenges were included. Notably, both approaches retrieved a similar number of initial articles overall, while the bibliometric analysis removed fewer duplicates and excluded fewer articles overall, leaving the total number of articles included in each approach as: 603 articles in the systematic review and 2372 articles in the bibliometric analysis. Nevertheless, both approaches identified the two main urban soil threats and/or challenges to be linked to soil organic carbon and/or heavy metals. This study gives timely input into the Zero pollution action plan and makes recommendations to stakeholders within the urban context.
The performance of metabolomics-based prediction scores for mortality in older patients with solid tumors
Authors: van Holstein Yara , Mooijaart Simon P. , van Oevelen Mathijs , van Deudekom Floor J. , Vojinovic Dina , Bizzarri Daniele , van den Akker Erik B. , Noordam Raymond , Deelen Joris , van Heemst Diana , de Glas Nienke A. , Holterhues Cynthia , Labots Geert , van den Bos Frederiek , Beekman Marian , Slagboom P. Eline , van Munster Barbara C. , Portielje Johanneke E. A. , Trompet Stella 
Published: July 2024

AbstractPrognostic information is needed to balance benefits and risks of cancer treatment in older patients. Metabolomics-based scores were previously developed to predict 5- and 10-year mortality (MetaboHealth) and biological age (MetaboAge). This study aims to investigate the association of MetaboHealth and MetaboAge with 1-year mortality in older patients with solid tumors, and to study their predictive value for mortality in addition to established clinical predictors. This prospective cohort study included patients aged ≥ 70 years with a solid malignant tumor, who underwent blood sampling and a geriatric assessment before treatment initiation. The outcome was all-cause 1-year mortality. Of the 192 patients, the median age was 77 years. With each SD increase of MetaboHealth, patients had a 2.32 times increased risk of mortality (HR 2.32, 95% CI 1.59–3.39). With each year increase in MetaboAge, there was a 4% increased risk of mortality (HR 1.04, 1.01–1.07). MetaboHealth and MetaboAge showed an AUC of 0.66 (0.56–0.75) and 0.60 (0.51–0.68) for mortality prediction accuracy, respectively. The AUC of a predictive model containing age, primary tumor site, distant metastasis, comorbidity, and malnutrition was 0.76 (0.68–0.83). Addition of MetaboHealth increased AUC to 0.80 (0.74–0.87) (p = 0.09) and AUC did not change with MetaboAge (0.76 (0.69–0.83) (p = 0.89)). Higher MetaboHealth and MetaboAge scores were associated with 1-year mortality. The addition of MetaboHealth to established clinical predictors only marginally improved mortality prediction in this cohort with various types of tumors. MetaboHealth may potentially improve identification of older patients vulnerable for adverse events, but numbers were too small for definitive conclusions. The TENT study is retrospectively registered at the Netherlands Trial Register (NTR), trial number NL8107. Date of registration: 22–10-2019.
Coffee consumption and cardiometabolic health: a comprehensive review of the evidence
Authors: Ungvari Zoltan , Kunutsor Setor K. 
Published: July 2024

AbstractThis review provides a comprehensive synthesis of longitudinal observational and interventional studies on the cardiometabolic effects of coffee consumption. It explores biological mechanisms, and clinical and policy implications, and highlights gaps in the evidence while suggesting future research directions. It also reviews evidence on the causal relationships between coffee consumption and cardiometabolic outcomes from Mendelian randomization (MR) studies. Findings indicate that while coffee may cause short-term increases in blood pressure, it does not contribute to long-term hypertension risk. There is limited evidence indicating that coffee intake might reduce the risk of metabolic syndrome and non-alcoholic fatty liver disease. Furthermore, coffee consumption is consistently linked with reduced risks of type 2 diabetes (T2D) and chronic kidney disease (CKD), showing dose-response relationships. The relationship between coffee and cardiovascular disease is complex, showing potential stroke prevention benefits but ambiguous effects on coronary heart disease. Moderate coffee consumption, typically ranging from 1 to 5 cups per day, is linked to a reduced risk of heart failure, while its impact on atrial fibrillation remains inconclusive. Furthermore, coffee consumption is associated with a lower risk of all-cause mortality, following a U-shaped pattern, with the largest risk reduction observed at moderate consumption levels. Except for T2D and CKD, MR studies do not robustly support a causal link between coffee consumption and adverse cardiometabolic outcomes. The potential beneficial effects of coffee on cardiometabolic health are consistent across age, sex, geographical regions, and coffee subtypes and are multi-dimensional, involving antioxidative, anti-inflammatory, lipid-modulating, insulin-sensitizing, and thermogenic effects. Based on its beneficial effects on cardiometabolic health and fundamental biological processes involved in aging, moderate coffee consumption has the potential to contribute to extending the healthspan and increasing longevity. The findings underscore the need for future research to understand the underlying mechanisms and refine health recommendations regarding coffee consumption.
Selfredepth
Authors: Duarte Alexandre , Fernandes Francisco , Pereira João M. , Moreira Catarina , Nascimento Jacinto C. , Jorge Joaquim 
Published: July 2024

AbstractDepth maps produced by consumer-grade sensors suffer from inaccurate measurements and missing data from either system or scene-specific sources. Data-driven denoising algorithms can mitigate such problems; however, they require vast amounts of ground truth depth data. Recent research has tackled this limitation using self-supervised learning techniques, but it requires multiple RGB-D sensors. Moreover, most existing approaches focus on denoising single isolated depth maps or specific subjects of interest highlighting a need for methods that can effectively denoise depth maps in real-time dynamic environments. This paper extends state-of-the-art approaches for depth-denoising commodity depth devices, proposing SelfReDepth, a self-supervised deep learning technique for depth restoration, via denoising and hole-filling by inpainting of full-depth maps captured with RGB-D sensors. The algorithm targets depth data in video streams, utilizing multiple sequential depth frames coupled with color data to achieve high-quality depth videos with temporal coherence. Finally, SelfReDepth is designed to be compatible with various RGB-D sensors and usable in real-time scenarios as a pre-processing step before applying other depth-dependent algorithms. Our results demonstrate our approach’s real-time performance on real-world datasets shows that it outperforms state-of-the-art methods in denoising and restoration performance at over 30 fps on Commercial Depth Cameras, with potential benefits for augmented and mixed-reality applications.
State-of-the-Art Review on Determining One-Dimensional Consolidation Parameters Based on Compression and Distribution of Pore Water Pressure: Coefficient of Consolidation (cv), End of Primary (EOP) Consolidation
Authors: Olek Bartłomiej Szczepan 
Published: July 2024

Abstract
Predicting the time rate of consolidation is one of the major aspects of structure design, founded on compressible fine-grained soil. The time to achieve the required advancement of the consolidation process is proportional to the coefficient of consolidation (c

v
). In practical applications, the settlement rate is directly related to the excess pore water pressure dissipation rate. A plethora of interpretation methods have been proposed for determining consolidation parameters from laboratory one-dimensional consolidation test in the past decades. This state-of-the-art review presents a comprehensive literature study of available approaches for establishing both coefficient of consolidation and end of primary (EOP) consolidation using compression and pore water pressure laboratory data. The classification of the methods has been made to set in order interpretation approaches for future selection and comparisons. The first part of the paper describes approaches based on graphical curve-fitting. This part includes five approaches: square root of time fitting approach, Semi-logarithmic fitting approach, Differential methods, Hyperbolic approach, and approach based on excess pore water pressure dissipation. In addition, a method comparison study has been performed to evaluate the degree of agreement between selected methods statistically. For this purpose, simple regression and Bland & Altman differences analysis have been used. The second part refers to the computational-based approach, covering a wide range of methods centred on full-matching treated by least-squares, correlational equations linking c

v
with index properties and soft computing approaches. A thorough insight into recently published literature on machine learning and physics-informed deep learning incorporated to derive the representative value of c

v
has also been compiled.
Comparison of coronary CT angiography and invasive coronary angiography results
Authors: Tekinhatun Muhammed , Akbudak İbrahim , Özbek Mehmet , Turmak Mehmet 
Published: July 2024

Abstract
Introduction
Coronary artery disease (CAD) is a leading cause of death worldwide. Accurate diagnosis and management are critical. Non-invasive imaging, such as coronary computed tomography angiography (CCTA), is vital for early diagnosis and treatment planning. This study evaluates the accuracy of CAD-Reporting and Data System (CAD-RADS) scoring and the compatibility between CCTA and invasive coronary angiography (ICA) in patients suspected of having CAD.

Materials and methods
From January 1, 2022 to January 15, 2024, 214 patients suspected of CAD underwent both CCTA and ICA. CCTA artifacts led to the exclusion of 32 patients and 128 vessels, leaving 586 vessels for analysis. CAD-RADS scoring categorized coronary stenosis. Diagnostic performance was measured by specificity, sensitivity, accuracy, positive and negative predictive value (NPV). Extracardiac findings were analyzed with a wide field of view (FOV) during CCTA.

Results
A total of 214 patients (67.3% male, median age 56) were examined. Hypertension, smoking, calcium score, and high-risk plaques correlated with CCTA and ICA CAD-RADS scores; calcium score also related to hypertension, smoking, diabetes, and dyslipidemia (p < 0.05). CCTA showed a sensitivity of 80.8% and NPV of 90.3% for detecting stenosis of 70% or more; for 50% stenosis, sensitivity was 93.5% and NPV 92.1%. Agreement between CCTA and ICA was excellent in bypass patients; stenosis detection in stented patients had 85.7% sensitivity and 96.2% NPV.

Conclusion
This study highlights the importance of CAD-RADS and CCTA in CAD diagnosis and treatment planning. CCTA effectively evaluates stents and grafts, emphasizing the benefits of extracardiac findings and a wide FOV.
Post-truth and post-trust: how to re-define trust in the judicial system and the media
Authors: Bayer Judit 
Published: July 2024

AbstractThis article revisits the rational and symbolic elements of assumed and earned trust, and how social and political trust is intertwined with trust in the judiciary and the media, as key control points in a democratic system. As such, they are also primary targets of populist-autocratic movements. The article enumerates how the transformation of the information environment has shattered traditional structures and opened new ways of questioning existing injustices. The result is an information landscape which is not only post-truth but also post-trust. New methods and processes of institutionalising processes of earning trust and structuring distrust have become necessary.
Construction of Gene Expression Profiles of the NAC Transcription Factor Family in Sugar Beet Under Abiotic Stress
Authors: Sun Yaqing , Li Changlun , Li Zhi , Jian Caiyuan , Li Ningning , Zhang Shaoying , Li Guolong 
Published: July 2024

AbstractSugar beet (Beta vulgaris L.) is a major sugar crop in China and an economic crop with regional advantages in the Inner Mongolia Autonomous Region. Currently, abiotic stresses are among the main factors restricting the high-quality development of the sugar beet industry. Recent research has shown that NAC transcription factors play an important role in regulating plant growth and development, as well as in resisting abiotic stress. To determine the specific expression of the NAC transcription factor family in different organs of sugar beet under different abiotic stress conditions, this study systematically analyzed the expression response of 52 members of the NAC transcription factor family in different organs to abiotic stress conditions using reverse transcription polymerase chain reaction technique. The responses of NAC transcription factor genes to different abiotic stresses were identified in sugar beet leaves and roots; 18 and 17 NAC transcription factor genes were found to respond specifically to abiotic stress in sugar beet leaves and roots, respectively. The research results provide a reference basis for using NAC transcription factors to develop stress-resistant germplasm resources in sugar beets.
Energy management system in networked microgrids: an overview
Authors: Rodriguez-Gil Jhojan A. , Mojica-Nava Eduardo , Vargas-Medina Daniel , Arevalo-Castiblanco Miguel F. , Cortes Camilo A. , Rivera Sergio , Cortes-Romero John 
Published: July 2024

AbstractEnergy management systems (EMS) play a crucial role in ensuring efficient and reliable operation of networked microgrids (NMGs), which have gained significant attention as a means to integrate renewable energy resources and enhance grid resilience. This paper provides an overview of energy management systems in NMGs, encompassing various aspects including system architecture, optimization algorithms, control strategies, and integration of distributed energy resources. The paper highlights the challenges and opportunities associated with energy management in NMGs and presents key approaches and technologies adopted in the field. Furthermore, it explores the implications of emerging trends such as data-driven modeling, machine learning, and advanced communication technologies on the design and performance of energy management systems in networked microgrids. Through this comprehensive overview, the paper aims to provide researchers, practitioners, and policymakers with valuable insights into the state-of-the-art developments and future directions in energy management systems for networked microgrids.
Characteristics of adult retroperitoneal lymphangioma: a single center Chinese cohort study of 15 cases
Authors: Liu Jie , Zhong Zhi-Han , Zheng Shu-Sen 
Published: July 2024

Abstract
Background
Lymphangioma is a rare cystic tumor that occurs across different locations. Retroperitoneal lymphangioma accounts for about 1% of all lymphangiomas. In this study, we report the clinicopathological features of retroperitoneal lymphangioma and describe our experience in treating this disease.

Methods
We collected clinical data from all patients who were pathologically diagnosed with retroperitoneal lymphangioma at Zhejiang Provincial People's Hospital, between June 2013 and August 2022.

Results
The 7 and 8 male and female patients analyzed herein had a mean age of 48.6 (SD 14.24) years at diagnosis. The mean duration of follow-up was 4.7 years. Among them, 66.67% were asymptomatic, with the rest manifesting abdominal pain, nausea, low back pain and elevated blood pressure as the main symptoms. Preoperative diagnosis and evaluation of cysts were mainly performed via computed tomography (CT) (n = 10, 66.67%) or magnetic resonance imaging (MRI) (n = 8, 53.33%). All patients were completely resected following surgery. Immunohistochemical analysis, performed on 6 patients, revealed that they were positive for D2-40. A total of 4, 4 and 3 patients were positive for CD31, CD34 and SMA, respectively. Moreover, the study cohort had an average postoperative hospital stay of 6.6 days. Follow up, after the end of the study, revealed no relapse in any of the 15 patients.

Conclusions
Lymphangioma is a benign tumor of the lymphatic system. Although typical imaging features can be accurate for preoperative diagnosis, histological examination is crucial to final confirmation. Complete surgical resection is the best option to limit the risk of recurrence in cases with symptomatic lesions.
Identification of hydrochemical processes of groundwater in Nekor-Ghiss plain (Morocco): using the application of multivariate statistics and Geographic Information Systems (GIS) to map groundwater
Authors: El khalki Soukaina , Ghalit Mohammad , Elbarghmi Rachida , Azzaoui Khalil , Jodeh Shehdeh , Hanbali Ghadir , Lamhamdi Abdellatif 
Published: July 2024

AbstractIn arid and semiarid zones, groundwater is a vital and indispensable natural resource. Indeed, these water resources have become extremely limited due to several factors, including climate change, salinization, and overexploitation. This study covers the hydrochemical characterization of groundwater in the Nekor-Ghiss plain which is located in northern Morocco. To achieve this objective, a set of 79 water samples was analyzed, for various physical and chemical parameters of the samples, including E.C, pH, TDS, HCO3−, SO42−, Ca2+, Mg2+, Na+, K+, PO43−, NO3−, NO2− and NH4+. Several methods were used to interpret the hydrochemical data, namely graphical methods, principal component analysis (PCA), hierarchical ascending classification, and ion exchange indices. A detailed geochemical study of groundwater is described to identify the origin of the chemical composition of groundwater. The results show that the samples studied are characterized by very high mineralization (> 1500 mg/l), with the predominance of Na+, Cl− and SO42− ions. The interpretation of geochemical signatures of groundwater in the Nekor-Ghiss plain shows sulfate-sodium (Na–SO4) and chloride-sodium (Na–Cl) facies. Natural geochemical processes are responsible for water regulation, while human activities exert a limited influence on this control. Marine intrusion, evaporation, and the ion exchange process largely control the chemistry of the aquifer. Using PCA to confirm controlled water chemistry processes revealed three homogeneous groups. The study contributes to a better understanding of the quality and mineralization of groundwater in the Nekor-Ghiss plain, and it will serve as a reference for other plains with similar characteristics.