bluuebunny/crossref_metadata_2025_split huggingface dataset:
Poétique du dialogue non dialogique dans les romans de Georges Darien et Octave Mirbeau
Authors: Le Sayec Loïc 
Published: July 2024

Écrivains libertaires, Georges Darien et Octave Mirbeau se distinguent par l’importance du volume des dialogues dans leurs romans. Cet article voudrait montrer que les dialogues jouent un rôle fondamental dans la dimension critique et polémique de leurs œuvres. Il s’agira pour ce faire d’étudier comment les auteurs réinvestissent un héritage romanesque varié à des fins polémiques. L’étude de ces structures romanesques conduira à analyser la manière dont les auteurs cherchent à exacerber le potentiel critique des dialogues en détournant des formes canoniques d’échanges verbaux entre personnages tout en ayant recours à des procédés d’exagération pouvant s’apparenter à la caricature. On interrogera enfin la tension au cœur du projet des auteurs qui emploient ces dialogues non dialogiques tout en refusant d’écrire des fictions autoritaires.
Éducation dans et par la nature et écoformation, évolution des pratiques et des conceptions éducatives des acteurs
Authors: Martin Émilie 
Published: July 2024

Cet article présente les principaux constats d’une recherche qui interroge les enjeux sous-jacents aux formes d’éducation par la nature et dans la nature, en s’intéressant aux pratiques pédagogiques mises en place et aux motivations d’enseignants et d’éducateurs à l’environnement. À partir d’une règle de vie collective - « je fais attention à moi, aux autres et à la nature » - rencontrée dans différents dispositifs éducatifs (classe dehors, forest school, école alternative en nature), cette recherche interroge les pratiques d’éducation par la nature et dans la nature au prisme des principaux éléments de réflexion apportés par la notion d’écoformation. L’évolution des conceptions de l’éducation et des postures pédagogiques des acteurs est ici questionnée en portant un regard sur la place laissée aux enfants et celle accordée au milieu dans les apprentissages, et sur les formes éducatives étudiées.
Safety and Efficacy of Injection Tenecteplase in 4.5 to 24 Hours Imaging Eligible Window Patients with Acute Ischemic Stroke (EAST-AIS) - Study Protocol
Authors: Pandit Awadh Kishor , Jatwani Arti , Tangri Poorvi , Srivastava Madakasira Vasantha Padma , Bhatia Rohit , Kale Shashank Sharad , Gaikwad Shailesh , Srivastava Achal Kumar , Garg Ajay , Joseph Leve Sebastian , Vibha Deepti , Vishnu Venugopalan Y. , Singh Rajesh Kumar , Radhakrishnan Divya M. , Das Animesh , Agarwal Ayush 
Published: July 2024

Abstract

Background and Aims:
Tenecteplase is used as the standard of care treatment for thrombolysis in acute ischemic stroke (AIS) patients within 4.5 h of symptom onset. Documented reports were less certain to claim the benefits of it in an extended window period. EAST-AIS (CTRI/2022/03/040718) trial is designed to determine the success rate of thrombolysis in an extended window period for good clinical outcomes.

Study Design:
It is a randomized, placebo-controlled trial of tenecteplase administered within 4.5–24 h of stroke onset (with or without large vessel occlusion) based on evidence of salvageable tissue through baseline computed tomography perfusion (CTP) or magnetic resonance imaging (MRI) scan. Criteria of patient inclusion are as follows: patients of both genders (male and female), age >18 years, pre-stroke modified Ranking Scale (mRS) <2, baseline NIHSS >5, CTP showing penumbra–ischemic core ratio >1.8, absolute difference in volume >10 ml, and ischemic core volume <70 ml. The sample size for the study is 100 patients: 50 in the tenecteplase arm (0.25 mg/kg body weight; maximum- 25 mg) and 50 in the placebo arm (controls).

Study Outcomes:
The study’s primary objective is safety endpoints along with the efficacy of tenecteplase assessed using the mRS score at 90 days of stroke onset.

Conclusion:
The result obtained from EAST-AIS will determine the safety and efficacy of tenecteplase injection administered 4.5–24 h following the symptom onset for AIS patients within the territory of Internal Carotid Artery (ICA), Middle Cerebral Artery (MCA), or Anterior Cerebral Artery (ACA) occlusion.
A Gender-based Study on the Morphometry of Cotyloid Cavity of the Coxal Bone in South Indian Population
Authors: Soman Meril Ann , Bhat Shivarama , Nallathamby Rani 
Published: July 2024

Abstract

Background and Aim:
The cotyloid cavity (acetabulum) is a cup-shaped hollow on the lateral aspect of the coxal bone. The head of the femur articulates with cotyloid cavity to form the hip joint. The cotyloid cavity varies in size, shape, and depth among individuals. Any deviation from the normal range of parameters of the acetabulum may result in arthrosis-related pathologies.

Materials and Methods:
The present study was conducted on 200 dry human hip bones. The bones were collected from the department of anatomy of a medical college in Mangalore. The following morphometrical parameters of the cotyloid cavity were measured: (a) transverse diameter of acetabulum, (b) acetabular height, (c) acetabular depth, (d) acetabular volume, (e) distance from the pubic tubercle to the anterior rim of the acetabulum, and (f) ratio between distance from the pubic tubercle to the anterior rim of the acetabulum and acetabular height. Range, mean, standard deviation, and standard error of mean were determined for each parameter. P value was also calculated. Gender-wise comparison of the results was done.

Results:
The independent t-test was done, and the P value was calculated for each parameter. All the parameters showed significant differences between the male and female hip bones.

Conclusion:
In this modern era, total and partial hip replacement surgeries are very commonly performed. Therefore, knowledge regarding the various morphometrical parameters of the cotyloid cavity may be of great help in the preoperative planning period. It would also be of great help in the fields of forensic anthropology, osteology, and anatomy.
Jeavons syndrome mimicking head nodding tic- A case report
Authors: Sheetal S. , Gladson Nikhil , John Rakesh , Kurup Yamuna P. 
Published: July 2024

Abstract
Jeavons syndrome is an uncommon generalized epilepsy syndrome characterized by a triad of eyelid myoclonia with or without absences, as indicated by epileptiform discharges on electroencephalography (EEG) precipitated by eye closure and photosensitivity. Eyelid myoclonia is an ictal phenomenon manifested as repeated fluttering or trembling of the eyelids or eyelid blinking, often precipitated by eye closure and light exposure. It has often been mistaken for eye-blinking tics. Myoclonic jerks involving the head, resembling a head shaking movement, may be observed in Jeavons syndrome, which may be misdiagnosed as a head nodding tic. Many case reports of this syndrome have incorrectly diagnosed eye blinking tics; however, misdiagnosis as head nodding tics is rarely reported. We report the case of a 10-year-old girl, referred to us for evaluation of head nodding tics, who was observed to have eyelid myoclonia and upward gaze deviation during photic stimulation. The patient’s EEG showed bursts of polyspike and wave discharges. She was diagnosed with Jeavons syndrome and was initiated on anti-epileptic agents.
Gedunin attenuates streptozotocin-induced diabetic hepatopathy in rats
Authors: Mazumdar Suchismita , Marar Thankamani M , Patki Jyoti M 
Published: July 2024

Objective:
To examine the hepatoprotective effects of gedunin in streptozotocin (STZ)-induced diabetic rats.

Methods:
Rats were divided into 4 groups: control, STZ, gedunin, and STZ+gedunin. Biochemical parameters for liver function and liver histology were studied. The molecular interaction of gedunin with the liver glucose transporters GLUT2 and SGLT1 was examined using AutoDock Vina.

Results:
Gedunin attenuated STZ-induced increase in the levels of aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase and gamma-glutamyl transferase in the serum and liver tissue, reduced lipid peroxidation, and enhanced antioxidant activity. Histopathological studies showed considerable restoration of liver architecture in gedunin-treated diabetic rats. In silico studies revealed stable binding of gedunin with GLUT2 and SGLT1.

Conclusions:
Gedunin exerts hepatoprotective effects in STZ-induced diabetic rats by reducing liver enzymatic activities and oxidative stress. Further studies are warranted to verify the mechanism of its hepatoprotective action.
C-phycocyanin shows neuroprotective effect against rotenone-induced Parkinson’s disease in mice
Authors: Rathod Hritik , Soni Ritu M. , Shah Jigna S. 
Published: July 2024

Objective:
To investigate the neuroprotective effect of C-phycocyanin in a mouse model of rotenone-induced Parkinson’s disease.

Methods:
C-phycocyanin (50 mg/kg, i.p., daily) was administered to rotenone (30 mg/kg, p.o., daily) treated mice for 28 days. Behavioral studies (Y-maze, rotarod, round beam walk, and wire-hang tests) were carried out to assess neurobehavioral deficits. Glutathione and malondialdehyde were determined in both serum and striatal tissue. Molecular proteins (AKT, AMPK, NF-κB, BDNF, and alpha-synuclein) in the striatum were estimated using ELISA. Histopathological analyses (hematoxylin and eosin stainning as well as Nissl staining) were carried out to assess structural abnormalities in the striatum.

Results:
C-phycocyanin significantly increased BDNF levels and decreased alpha-synuclein levels. It also slightly upregulated AMPK and AKT levels without significant difference compared with the rotenone group. Additionally, rotenone-induced elevated oxidative stress and structural abnormalities in the striatum were markedly mitigated by C-phycocyanin.

Conclusions:
C-phycocyanin might have potential neuroprotective effects against Parkinson’s disease. Further studies are warranted to verify its efficacy and to understand the molecular mechanisms behind the neuroprotective effects of C-phycocyanin in Parkinson’s disease.
Participatory Security as Form of Control: Kaziranga National Park, India
Authors: Fanari Eleonora 
Published: July 2024

Abstract
‘More security, more conservation’ is the mantra utilised by the Indian forest service to ensure the protection of flora and fauna. Aligned with international agreements aiming at securing wildlife and preserving forests, the Union and the State governments of India have adopted a series of green measures to ensure both the securitisation and participation of local communities in conservation efforts. This research article illustrates how participatory forms of conservation are employed to complement the securitisation of conservation, serving as a means to indirectly control people’s lives and create new environmental subjects. It does so through a case study of Kaziranga National Park, a biodiversity conservation hotspot in the northeastern state of Assam, renowned for the successful conservation of the Greater One-horned Rhino Rhinoceros unicornis. This ‘success’ emerges amidst critiques of its violent and militarised anti-poaching conservation measures and the efforts deployed to protect the rhino ‘at any cost’. The research article analyses the participatory protection mechanisms supported by state and non-state agencies to ensure the conservation of Kaziranga, primarily carried out through the revitalisation of two bodies: the eco-development committee and the voluntary defence organisation. The results demonstrate how soft forms of violence complement hard forms, thereby supporting a broader process of structural violence and national building in Assam. It shows how participatory mechanisms are used as ‘counterinsurgency practices.’

Abstract in Hindi: rb.gy/rhcrzz
Psychological Health and Coronavirus Disease 2019-related Knowledge, Attitude, and Behavioral Practices among Industrial Workers: A Cross-sectional Study
Authors: Mohammadiyan Mahdi , Kangarlou Marzieh Belji , Chamani Abbasali , Mohammadi Saeed 
Published: July 2024

Abstract

Aim:
The spread of the coronavirus disease 2019 (COVID-19) pandemic has imposed a high threat on the health of industrial workers as the most crucial source of the workforce in maintaining business and the community economy. The present study was conducted toevaluate the levels of psychological health and knowledge, attitude, and behavioral practice (KAP) relating to COVID-19 and to investigatethe individual and occupational risk factors associated with them.

Materials and Methods:
A cross-sectional study was conducted among 603 randomly selected workers from Tehran industrial city, Iran. Data collected through an online self-reporting questionnaire consisted of demographic variables, Depression, Anxiety, and Stress Scale (DASS-21), and items about KAP. Kruskal–Wallis, Mann–Whitney U-tests, and regression model analyses were performed to determine the factors associated with DASS-21 and KAP scales.

Results:
In this study, a prevalence of moderate to extremely severe symptoms was 30.2% for depression, 35.7% for anxiety, and 15.6% for stress. 89.9%, 95.3%, and 66% of the workers had moderate knowledge, attitude, and good behavioral practice, respectively. Home appliance industry (adjusted odds ratio [aOR] = 0.84, P = 0.002), work experience over 16–20 years old (aOR = 0.38, P = 0.031), and having an associate’s degree (aOR = 0.82, P = 0.02) were positively associated with worker’s attitude, depression, and knowledge, respectively.

Conclusion:
The findings indicated a considerable proportion of psychological health problems, particularly depression, anxiety, and stress among workers across industries. Occupational health services should provide interventions to improve knowledge, particularly in disease transmission, increase awareness, and emphasize appropriate preventive measures to reduce workplace chronic stressors and improve psychological health.
Determinants of multimorbidity among elderly population in maharashtra, India: Logistic regression analysis
Authors: Santhosh Reshma , Kakade Satish V. , Durgawale PM 
Published: July 2024

BACKGROUND:
Population aging is an emerging global trend. Because of decreasing fertility rates and improved healthcare, the lifespan of elderly population increased. Consequently, proportion of elderly population is increasing at an alarming rate. This is accompanied by an increased recognition of the occurrence of multimorbidity and associated mortality risks. So, the purpose of this study was to determine the prevalence and predictors of multimorbidity among elderly population in Maharashtra with its variation among socio-demographic spectrum, functional health and health behaviors.

MATERIALS AND METHODS:
Sample of elderly population aged > 60 years were selected to examine multimorbidity and its associated risk factors. Statistical methods such as Chi-square test were used to show the association between multimorbidity and other covariates. Binary logistic regression analysis was used to understand the effects of predictor variables on multimorbidity. Receiver Operating Characteristic (ROC) Curve Analysis was carried out to improve the performance of the classification model by using a modified cut-off probability value. Z scores were calculated to compare model performance in training data and test data.

RESULTS:
The prevalence of multimorbidity in Maharashtra in training data and test data was found to be 32.8% and 32.9%. Residence, living arrangement, MPCE Quintile, marital status, work status, education, tobacco consumption, physical activity, Instrumental Activities of Daily Living (IADL), Activities of Daily Living (ADL) and self-rated health of elderly population were important determinants that exert a significant adverse effect on multimorbidity.

CONCLUSION:
Prediction percentages indicate that appropriate actions should be undertaken to ensure good quality of life for all the elderly in Maharashtra.
Endoscopic transcanal facial nerve decompression in traumatic facial nerve palsy: A case series
Authors: Bandyopadhyay Arjyama , Rout Khageswar 
Published: July 2024

Abstract
Temporal bone fractures contribute to 7%–10% of patients suffering from facial nerve (FN) palsy.Traumatic facial paralysis is the most common cause of lower motor neuron facial paralysis, accounting for about 17% of its incidence. Temporal bone fractures contribute to 7%–10% of patients suffering from facial nerve (FN) palsy. The proximal tympanic segment of FN is most commonly affected in such cases. The classical microscopic surgeries for pathologies involving the FN, such as transmastoid approach, middle cranial fossa approach, and translabyrinthine approach, are associated with several disadvantages. The endoscopic transcanal approach is a minimally invasive surgery that can be used mostly for a lesion limited to the tympanic segment of the FN. It provides sufficient exposure for nerve decompression as compared to other approaches. Clear endoscopic vision of the tympanic cavity is also achieved, which is beneficial to ossicular chain reconstruction. Moreover, it causes minimal surgical trauma. Operating time and postoperative hospital stay are also reduced. This technique is cosmetically more acceptable to the patient. In this article, we report three cases of posttraumatic FN palsy where we performed endoscopic transcanal nerve decompression. It resulted in dramatic improvement of the facial palsy from House–Brackmann Grade IV or Grade V to Grade II immediately following surgery. The outcome of FN decompression through this approach was found to be comparable to conventional approach.
Role of traditional Chinese medicine-based acupuncture in the resolution of ovarian torsion
Authors: Shubha R. , Silwal Karishma , Nair Pradeep M. K. 
Published: July 2024

Abstract
Ovarian torsion (OT) is a gynecological emergency that affects females of childbearing age and usually requires surgical management. Here, we present a 30-year-old female who presented with an ultrasonographically confirmed OT along with an ovarian cyst and severe pain in the lower abdomen. She was treated at a private acupuncture clinic as an outpatient. She underwent one acupuncture session per week for 11 weeks. St 40, Sp6, Sp9, Lv3, Li4, CV4, St 29, K6, Lu7, Sp4, and Pc6 were selected and punctured based on traditional Chinese medicine diagnosis. The patient reported mild relief from pain immediately after the first session. A complete relief of pain was reported by the patient by the end of the third session. A follow-up ultrasound revealed no significant ovarian abnormality. This report indicates the possibility of using acupuncture in emergency conditions like OT.
A rare case of chronic headache
Authors: Miriyala Srinivas , Challagulla Madhubabu , Agarwal Pooja , Mohanty Lalatendu , Rao Bangam Rajendra Prasad 
Published: July 2024

Abstract
Cerebral venous thrombosis (CVT) is a relatively uncommon and rare condition worldwide, affecting approximately 1 in 100,000 individuals annually and comprising about 0.5% of all strokes. It is more prevalent in women of childbearing age due to hypercoagulable states. We present a case report of a 19 years old female exhibiting symptoms, including headache, occasionally associated vomiting, blurring of vision and one generalised seizure. On general examination and neurological, there were no significant abnormality found, Fundoscopy revealed blurred disc margins and the presence of papilledema. An emergency non-contrast computed tomography (NCCT) scan of the brain showed normal findings. Subsequently, a magnetic resonance imaging (MRI) scan of the brain indicated partial loss of flow void in the posterior part of the superior sagittal sinus and straight sinus, along with the formation of collateral channels, suggestive of possible subacute dural sinus thrombosis. Additionally, a contrast-enhanced MRI (CEMRI) scan with MR venogram showed filling defects in the posterior part of the superior sagittal sinus and straight sinus, with non-visualization of the left transverse sinus, indicative of subacute to chronic dural venous thrombosis, Beta 2 glycoprotein IgM and Cardiolipin IgM were positive and titres were high. This case with history of headache for 4 years underscores the need for early diagnosis, which could have alleviated suffering and further prevent grave consequences, with an insight to such problems and accessibility to high end imaging diagnosis tools for early recognition and management.
Ocular hypertension in a child of acute lymphoblastic leukemia
Authors: Sen Saswati , Das Matuli , Parida Shrutakirty 
Published: July 2024

Abstract
To highlight the case of ocular hypertension in a 9-year-old male who came with fever and swelling in the left eye (LE) for 3 days. He was a known case of acute lymphoblastic leukemia (ALL) on treatment with oral steroids. His best-corrected vision was 6/6 in both eyes (BES). The anterior segment was normal in BES except for mild periorbital edema in the right eye (RE). On applanation tonometry (AT), intraocular pressure (IOP) was 42 mmHg in RE and 36 mmHg in LE. Gonioscopy showed open angles in BEs. Fundoscopy and optical coherence tomogram–retinal nerve fiber layer were normal in BES. He was diagnosed with steroid-induced ocular hypertension in BES and was started on both topical and oral antiglaucoma medications (AGMs). IOP was normal after 2 weeks of treatment. He came after a month of discontinuation of AGMs against medical advice but was still on oral steroids. He was asymptomatic, but his IOP was 28 mmHg in RE and 26 mmHg in LE. Parents were counseled about the disease and need to restart AGMs. Regular follow-up was also emphasized.
Histomolecular subtyping of periampullary adenocarcinoma and its correlation with pathological prognostic factors
Authors: Goyal Namisha , Pradhan Prita , Giri Ranjana , Sahoo Subrat Kumar 
Published: July 2024

Abstract

Introduction:
Periampullary adenocarcinoma (PAC) is a less frequent tumor accounting for approximately 0.5%–2% of all gastrointestinal malignancies. Histologically, PAC subtyped into intestinal and pancreaticobiliary adenocarcinoma which is further confirmed by immunohistochemistry (IHC). Subtyping of PAC has emerged as an important prognostic factor with potential therapeutic implications.

Aim:
The aim of the study was to assess morphology and IHC expression of CK7, CK20, and CDX2 to subtype PAC and correlate the subtype predicted on histomorphology with the immunohistochemical expression.

Materials and Methods:
This was a cross-sectional study done from January 2018 to July 2023. A total of 28 pancreaticoduodenectomy specimens were assessed and further classified into intestinal and pancreaticobiliary subtypes after correlating both histological and immunohistochemical features. Statistical analysis was performed using the standard statistical software. P <0.05 was considered statistically significant.

Results:
Histomorphology and IHC (CK7, CK20, and CDX2) expression was studied in 28 cases having an age range from 41 to 74 years including 18 males. Based on histomorphological findings, they are categorized into intestinal (n = 15) and pancreaticobiliary (n = 13) subtypes. The use of only morphology showed a sensitivity, specificity, and diagnostic accuracy of 63.6%, 52.9%, and 53.16%, respectively, for the intestinal subtype and 50%, 57%, and 57%, respectively, for the pancreaticobiliary subtype. With the use of combined histomorphology and IHC the sensitivity, specificity, and diagnostic accuracy was >90% with a significant reduction in false-positive diagnosis.

Conclusion:
The correlation of histomorphology and IHC findings can aid in better subtyping of PAC.