bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermal expansion behaviour of orthopyroxenes: the role of the Fe-Mn substitution
Authors: Scandolo L. , Mazzucchelli M. L. , Alvaro M. , Nestola F. , Pandolfo F. , Domeneghetti M. C. 
Published: May 2015

AbstractTwo Pbca orthopyroxene samples, donpeacorite (DP N.1) and enstatite (B22 N.60) with chemical formulae Mn0.54Ca0.03Mg1.43Si2O6(XMn= 0.27) and Fe0.54Ca0.03Mg1.43Si2O6(XFe= 0.27), respectively, were investigated by single-crystal X-ray diffraction at high-temperature conditions.The nearly identical XFeand XMnmake the two samples the perfect candidates to investigate the effect of the compositional change at theM2 site (i.e. Fe-Mn substitution) on the thermal expansion behaviour of orthopyroxenes.Therefore, the unit-cell parameter thermal expansion behaviour of both samples has been investigated in the temperature range between roomTand 1073 K. No evidence for phase transitions was found over that range. The two samples have been previously disordered with anex situannealing at ∼1273 K.The unit-cell parameters and volume thermal expansion data, collected on the disordered samples, have been fitted to a Fei Equation of State (EoS) and the following coefficients obtained: V0= 853.35(4) Å3, αV,303K= 2.31(24) × 10–5K–1and V0= 845.40(6) Å3, αV,303K= 2.51(25) × 10–5K–1for DP N.1 and B22 N.60, respectively.While there is no difference in the volume thermal expansion coefficient as a function of composition and the expansion along thebdirection is nearly identical for both samples, slight differences have been found alongaandclattice directions. The thermal expansion along theadirection is counterbalanced by that alongcbeing responsible for the changes in lattice expansion scheme from αb> αc> αaat room T, to αc> αb> αaat high T. Therefore, as a result of the different behaviour alongaandc, the unit-cell volume thermal expansion for both samples is identical within estimated standard deviations. The negligible effect of the Fe-Mn substitution on the bulk thermal expansion can be applied when dealing with geothermobarometry based on the elastic host-inclusion approach (e.g. Nestolaet al., 2011; Howellet al., 2010; Angelet al., 2014a, b, 2015). In fact, though the compressibility effect is still not known, the nearly identical thermal expansion coefficients will not affect the entrapment pressure (Pe).
From ancient pigments to modern optoelectronic applications of arsenic sulfides: bonazziite, the natural analogue of β-As4S4from Khaidarkan deposit, Kyrgyzstan
Authors: Bindi Luca , Pratesi Giovanni , Muniz-Miranda Maurizio , Zoppi Matteo , Chelazzi Laura , Lepore Giovanni O. , Menchetti Silvio 
Published: May 2015

AbstractBonazziite is a new mineral from Khaidarkan deposit, Kyrgyzstan and represents the natural analogue of the β-form of the well known As4S4compound. It occurs as rare crystals up to 100 μm across associated with realgar, sulfur, wakabayashilite, alacránite, non-stoichiometric As4S4+xsulfides and stibnite in a calcite matrix. In thick section, bonazziite is opaque with a resinous lustre and a dark-orange streak. It is brittle; the Vickers hardness (VHN15) is 70 kg/mm2(range: 60–76) (Mohs hardness of ∼2½). In plane-polarized incident light, bonazziite is strongly bireflectant and pleochroic from orange to light red. The mineral shows orange to red internal reflections. Between crossed polars, the mineral is strongly anisotropic with greyish to light-blue rotation tints. Reflectance percentages in air for Rminand Rmaxare 19.9, 22.2 (471.1 nm), 19.1, 21.3 (548.3 nm), 18.8, 19.7 (586.6 nm) and 17.8, 18.9 (652.3 nm), respectively. Bonazziite is monoclinic, space group C2/c, witha= 9.956(1),b= 9.308(1),c= 8.869(1) Å, β = 102.55(2)° andV= 802.3(2) Å3,Z= 4. The crystal structure [R1= 0.0263 for 735 reflections with Fo> 4σ(Fo)] is based on the As4S4cage-like molecule, in which each As atom links one As and two S atoms. The As4S4 molecule is identical to that found in the structure of realgar. The six strongest powder diffraction lines [din Å(I/I0) (hkl)] are: 5.74 (100) (1̄11); 4.10 (60) (021); 3.92 (50) (1̄12); 3.12 (60) (022, 310); 2.95 (50) (221, 202); 2.86 (80) (2̄22, 1̄31). a mean of six electron microprobe analyses gave the formula As3.95S4.05, on the basis of eight atoms. The new mineral has been approved by the International Mineralogical Association Commission on New Minerals, Nomenclature and Classification (IMA No. 2013-141) and named for Paola Bonazzi, in recognition of her seminal contributions to the study of arsenic sulfides and their alteration induced by exposure to light.
New arsenate minerals from the Arsenatnaya fumarole, Tolbachik volcano, Kamchatka, Russia. III. Popovite, Cu5O2(AsO4)2
Authors: Pekov Igor V. , Zubkova Natalia V. , Yapaskurt Vasiliy O. , Belakovskiy Dmitry I. , Vigasina Marina F. , Sidorov Evgeny G. , Pushcharovsky Dmitry Yu. 
Published: May 2015

AbstractThe new mineral popovite, Cu5O2(AsO4)2, was found in the sublimates of the Arsenatnaya fumarole at the Second scoria cone of the Northern Breakthrough of the Great Tolbachik Fissure Eruption, Tolbachik volcano, Kamchatka, Russia. It is associated with ericlaxmanite, kozyrevskite, urusovite, lammerite, lammerite-β, johillerite, bradaczekite, tenorite, hematite, aphthitalite, anhydrite, langbeinite, calciolangbeinite, As-bearing orthoclase, etc. Popovite occurs as prismatic or tabular crystals and as grains up to 0.2 mm in size forming clusters up to 1.5 mm in size and as crusts on basalt scoria or on aphthitalite incrustations. Popovite is transparent with a vitreous to greasy lustre. Its colour is olive green to dark olive-green, but fine-grained varieties are light yellow-green. The mineral is brittle, with Mohs' hardness ∼3½. Cleavage was not observed and the fracture is uneven.Dcalcis 5.30 g cm–3. Popovite is optically biaxial (+), α = 1.84(1), β ≈ 1.86, γ = 1.96(1), 2Vmeas= 50(20)°. The Raman spectrum is given. Chemical data (wt.%, electron-microprobe) are CuO 63.28, ZnO 0.56, V2O50.12, As2O535.80, SO30.27, total 100.03. The empirical formula, based on 10 O a.p.f.u., is (Cu4.99Zn0.04)Σ5.03(As1.95S0.02V0.01)Σ1.98O10. Popovite is triclinic, P1̄,a= 5.1450(3),b= 6.2557(3),c= 6.2766(4) Å, α = 100.064(5), β = 96.351(5), γ = 95.100(5)°,V= 196.47(1) Å3andZ= 1. The strongest reflections in the powder X-ray diffraction pattern [d, Å(I)(hkl)] are 3.715(36)(110, 101), 3.465(43)(11̄1), 2.968(90)(01̄2), 2.927(100)(111), 2.782(31)(1̄02), 2.768(67)(1̄20), 2.513(55)(1̄2̄1) and 2.462(67)(2̄01). Popovite has a novel structure type. Its crystal structure, solved from single-crystal X-ray diffraction data (R = 0.0459), is based on (010) layers forming an interrupted framework. The layer consists of Cu(1)O6octahedra with very strong Jahn-Teller distortion and Cu(2)O5and Cu(3)O5polyhedra. The linkage between the layers is reinforced by isolated AsO4tetrahedra. Popovite is named in honour of the Russian mineralogists Vladimir Anatol'evich Popov (b. 1941) and Valentina Ivanovna Popova (b. 1941), a husband and wife research team working in the Institute of Mineralogy of the Urals Branch of the Russian Academy of Sciences, Miass, Russia.
Brain tumor is a sequence-specific RNA-binding protein that directs maternal mRNA clearance during the Drosophila maternal-to-zygotic transition
Authors: Laver John D , Li Xiao , Ray Debashish , Cook Kate B , Hahn Noah A , Nabeel-Shah Syed , Kekis Mariana , Luo Hua , Marsolais Alexander J , Fung Karen YY , Hughes Timothy R , Westwood J Timothy , Sidhu Sachdev S , Morris Quaid , Lipshitz Howard D , Smibert Craig A 
Published: May 2015

Abstract
Background
Brain tumor (BRAT) is a Drosophila member of the TRIM-NHL protein family. This family is conserved among metazoans and its members function as post-transcriptional regulators. BRAT was thought to be recruited to mRNAs indirectly through interaction with the RNA-binding protein Pumilio (PUM). However, it has recently been demonstrated that BRAT directly binds to RNA. The precise sequence recognized by BRAT, the extent of BRAT-mediated regulation, and the exact roles of PUM and BRAT in post-transcriptional regulation are unknown.

Results
Genome-wide identification of transcripts associated with BRAT or with PUM in Drosophila embryos shows that they bind largely non-overlapping sets of mRNAs. BRAT binds mRNAs that encode proteins associated with a variety of functions, many of which are distinct from those implemented by PUM-associated transcripts. Computational analysis of in vitro and in vivo data identified a novel RNA motif recognized by BRAT that confers BRAT-mediated regulation in tissue culture cells. The regulatory status of BRAT-associated mRNAs suggests a prominent role for BRAT in post-transcriptional regulation, including a previously unidentified role in transcript degradation. Transcriptomic analysis of embryos lacking functional BRAT reveals an important role in mediating the decay of hundreds of maternal mRNAs during the maternal-to-zygotic transition.

Conclusions
Our results represent the first genome-wide analysis of the mRNAs associated with a TRIM-NHL protein and the first identification of an RNA motif bound by this protein family. BRAT is a prominent post-transcriptional regulator in the early embryo through mechanisms that are largely independent of PUM.
Comparative effectiveness of urate lowering with febuxostat versus allopurinol in gout: analyses from large U.S. managed care cohort
Authors: Singh Jasvinder A , Akhras Kasem S , Shiozawa Aki 
Published: May 2015

Abstract
Introduction
To assess the comparative effectiveness of febuxostat and allopurinol in reducing serum urate (sUA) levels in a real-world U.S. managed care setting.

Methods
This retrospective study utilized 2009 to 2012 medical and pharmacy claims and laboratory data from a large U.S. commercial and Medicare Advantage health plan. Study patients had at least one medical claim with a diagnosis of gout, at least one filled prescription for febuxostat or allopurinol and at least one sUA measurement post-index prescription. Reduction in sUA was examined using propensity score-matched cohorts, matched on patient demographics (gender, age), baseline sUA, comorbidities, geographic region and insurance type.

Results
The study sample included 2,015 patients taking febuxostat and 14,025 taking allopurinol. At baseline, febuxostat users had a higher Quan-Charlson comorbidity score (0.78 vs. 0.53; P <0.001), but similar age and gender distribution. Mean (standard deviation (SD)) sUA level following propensity score matching among treatment-naïve febuxostat vs. allopurinol users (n = 873 each) were: pre-index sUA, 8.86 (SD, 1.79) vs. 8.72 (SD, 1.63; P = 0.20); and post-index sUA, 6.53 (SD, 2.01) vs. 6.71 (SD, 1.70; P = 0.04), respectively. A higher proportion of febuxostat users attained sUA goals of <6.0 mg/dl (56.9% vs. 44.8%; P <0.001) and <5.0 mg/dl (35.5% vs. 19.2%; P <0.001), respectively. Time to achieve sUA goals of <6.0 mg/dl (346 vs. 397 days; P <0.001) and <5.0 mg/dl was shorter in febuxostat vs. allopurinol users (431 vs. 478 days; P <0.001), respectively. Similar observations were made for overall propensity score-matched cohorts that included both treatment-naïve and current users (n = 1,932 each).

Conclusions
Febuxostat was more effective than allopurinol at the currently used doses (40 mg/day for febuxostat in 83% users and 300 mg/day or lower for allopurinol in 97% users) in lowering sUA in gout patients as demonstrated by post-index mean sUA level, the likelihood of and the time to achieving sUA goals.
Activating enhancer binding protein 2 epsilon (AP-2ε)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development
Authors: Niebler Stephan , Schubert Thomas , Hunziker Ernst B , Bosserhoff Anja K 
Published: May 2015

Abstract
Introduction
The transcription factor activating enhancer binding protein 2 epsilon (AP-2ε) was recently shown to be expressed during chondrogenesis as well as in articular chondrocytes of humans and mice. Furthermore, expression of AP-2ε was found to be upregulated in affected cartilage of patients with osteoarthritis (OA). Despite these findings, adult mice deficient for AP-2ε (Tfap2e−/−) do not exhibit an obviously abnormal cartilaginous phenotype. We therefore analyzed embryogenesis of Tfap2e−/− mice to elucidate potential transient abnormalities that provide information on the influence of AP-2ε on skeletal development. In a second part, we aimed to define potential influences of AP-2ε on articular cartilage function and gene expression, as well as on OA progression, in adult mice.

Methods
Murine embryonic development was accessed via in situ hybridization, measurement of skeletal parameters and micromass differentiation of mesenchymal cells. To reveal discrepancies in articular cartilage of adult wild-type (WT) and Tfap2e−/− mice, light and electron microscopy, in vitro culture of cartilage explants, and quantification of gene expression via real-time PCR were performed. OA was induced via surgical destabilization of the medial meniscus in both genotypes, and disease progression was monitored on histological and molecular levels.

Results
Only minor differences between WT and embryos deficient for AP-2ε were observed, suggesting that redundancy mechanisms effectively compensate for the loss of AP-2ε during skeletal development. Surprisingly, though, we found matrix metalloproteinase 13 (Mmp13), a major mediator of cartilage destruction, to be significantly upregulated in articular cartilage of adult Tfap2e−/− mice. This finding was further confirmed by increased Mmp13 activity and extracellular matrix degradation in Tfap2e−/− cartilage explants. OA progression was significantly enhanced in the Tfap2e−/− mice, which provided evidence for in vivo relevance. This finding is most likely attributable to the increased basal Mmp13 expression level in Tfap2e−/− articular chondrocytes that results in a significantly higher total Mmp13 expression rate during OA as compared with the WT.

Conclusions
We reveal a novel role of AP-2ε in the regulation of gene expression in articular chondrocytes, as well as in OA development, through modulation of Mmp13 expression and activity.
Some coincidence point results for generalized $(\psi,\varphi)$-weakly contractions in ordered b-metric spaces
Authors: Roshan Jamal R , Parvaneh Vahid , Radenović Stojan , Rajović Miloje 
Published: May 2015

AbstractIn this paper we present some coincidence point results for four mappings satisfying generalized $( \psi,\varphi ) $
(
ψ
,
φ
)
-weakly contractive condition in the framework of ordered b-metric spaces. Our results extend, generalize, unify, enrich, and complement recently results of Nashine and Samet (Nonlinear Anal. 74:2201-2209, 2011) and Shatanawi and Samet (Comput. Math. Appl. 62:3204-3214, 2011). As an application of our results, periodic points of weakly contractive mappings are obtained. Also, an example is given to support our results.
Warthin's tumor of the larynx: A very rare case and systematic review of the literature
Authors: Nisa Lluís , Landis Basile Nicolas , Salmina Cinzia , Ailianou Angeliki , Karamitopoulou Eva , Giger Roland 
Published: May 2015

Background Warthin's tumor or cystadenolymphoma (CAL) is a benign salivary gland tumor occurring almost exclusively in the parotid gland. CALs of other locations are rare. Case presentation We report a laryngeal CAL detected in a positron emission tomography/computed tomography (PET/CT) performed for breast cancer follow-up. The tumor was successfully treated by transoral surgery. Discussion Only 14 cases of laryngeal CAL are reported worldwide. These cases confirmed our experience of an uncomplicated and mostly successful transoral resection. Conclusion CALs of the larynx are very rare. They are characterized by hypermetabolism in PET/CT. The increasing use of PET/CT investigations in cancer patients could give rise to more incidental findings of CALs at unusual locations such as the larynx.
The process of designing interior textile products & the influence of Design for the Environment (DfE)
Authors: Calamari Sage , Hyllegard Karen H 
Published: May 2015

AbstractThis study examined the processes involved in the design of interior textile products, with emphasis upon processes undertaken by designers’ who are committed to a Design for the Environment (DfE) orientation. Handfield et al. (IEEE TEM 48:189–208, 2001) model of product design and development provided a context by which to explore inclusion of environmental performance criteria within the design process. Data were collected through interviews with twelve professional designers of interior textile products. Analyses revealed six themes or stages in the design process for interior textile products: resources and research, consumer need and trend identification, inspiration, creative exploration, product samples, and design completion. DfE-oriented designers and conventional designers did not differ in their narratives regarding design process however, the focus and scope of decision-making within each theme or stage allowed for an additional component to the DfE-oriented design and development process of interior textile products.
The endothelial deprotection hypothesis for lupus pathogenesis: the dual role of C1q as a mediator of clearance and regulator of endothelial permeability
Authors: Prechl József , Czirják László 
Published: May 2015

Systemic lupus erythematosus (SLE) is a heterogeneous multifactorial systemic autoimmune disease affecting several organs. SLE can start relatively early in life and results in impaired quality of life and shortened life expectancy because of a gradual disease progression leading to cardiovascular, renal and neoplastic disease. The basic mechanisms of the pathogenesis of the disease still remain to be clarified. It is clear that complement proteins play a key and complex role in the development of SLE. Complement component C1q has been known to be a fundamental component of lupus development, but most explanations focus on its role in apoptotic debris removal. Importantly, C1q was recently found to play a key role in the maintenance of vascular endothelial integrity.We suggest that apoptotic products, endothelial cells and extracellular matrix components, which display negatively charged moieties, compete for binding to molecules of the innate humoral immune response, like C1q. Genetic or acquired factors leading to an increased load of apoptotic cell debris and decrease or absence of C1q therefore interfere with the regulation of endothelial permeability and integrity. Furthermore, we suggest that lupus is the net result of an imbalance between the two functions of immune clearance and vascular endothelial integrity maintenance, an imbalance triggered and sustained by autoimmunity, which skews C1q consumption by IgG-mediated complement classical pathway activation on autoantigens. In this triangle of innate clearance, autoimmunity and endothelial integrity, C1q plays a central role.Hence, we interpret the pathogenesis of lupus by identifying three key components, namely innate immune clearance, autoimmunity and endothelial integrity and we establish a link between these components based on the protective role that innate clearance molecules play in endothelial renewal. By including the vasoprotective role of C1q in the interpretation of SLE development we attempt to provide novel explanations for the symptoms, organ damage, diagnostic and therapeutic difficulties of the disease.
A Structural Model of Employee Behavioral Dynamics in Enterprise Social Media
Authors: Huang Yan , Singh Param Vir , Ghose Anindya 
Published: May 2015

We develop and estimate a dynamic structural framework to analyze the social-media content creation and consumption behavior of employees within an enterprise. We focus, in particular, on employees’ blogging behavior. The model incorporates two key features that are ubiquitous in blogging forums: users face (1) a trade-off between blog posting and blog reading; and (2) a trade-off between work-related and leisure-related content. We apply the model to a unique data set comprising the complete details of the blog posting and reading behavior of employees over a 15-month period at a Fortune 1000 IT services and consulting firm. Despite getting a higher utility from work-related blogging, employees nevertheless publish a significant number of leisure posts. This is partially because the creation of leisure posts has a significant positive spillover effect on the readership of work posts. Counterfactual experiments demonstrate that leisure-related blogging has positive spillovers for work-related blogging, and hence a policy of abolishing leisure-related content creation can inadvertently have adverse consequences on work-related content creation in an enterprise setting. When organizations restrict leisure blogging, the sharing of online work-related knowledge decreases and this in turn can also reduce employee performance rating. Overall, blogging within enterprises by employees during their work day can have positive long-term benefits for organizations. This paper was accepted by Lorin Hitt, information systems.
Competing for Attention in Social Communication Markets
Authors: Iyer Ganesh , Katona Zsolt 
Published: May 2015

We investigate the incentives for social communication in the new social media technologies. Three features of online social communication are represented in the model. First, new social media platforms allow for increased connectivity; i.e., they enable sending messages to many more receivers, for the same fixed cost, compared to traditional word of mouth. Second, users contribute content because they derive status- or image-based utility from being listened to by their peers. Third, we capture the role of social differentiation, or how social distance between people affects their preferences for messages. In the model, agents endogenously decide whether to be a sender of information and then compete for the attention of receivers. An important point of this paper is that social communication incentives diminish even as the reach or the span of communication increases. As the span of communication increases, competition between senders for receiver attention becomes more intense, resulting in senders competing with greater equilibrium messaging effort. This in turn leads to lower equilibrium payoffs and the entry of fewer senders. This result provides a strategic rationale for the so-called participation inequality phenomenon, which is a characteristic of many social media platforms. We also show that social differentiation may enhance or deter sender entry depending on whether it can be endogenously influenced by senders. Finally, we examine how the underlying network structure (in terms of its density and its degree distribution) affects communication and uncover a nonmonotonic pattern in that increased connectivity first increases and then reduces the entry of senders. This paper was accepted by Pradeep Chintagunta, marketing.