bluuebunny/crossref_metadata_2025_split huggingface dataset:
Change of self-rated physical health predicts mortality in aging individuals: results of a population-based cohort study
Authors: Reinwarth Anna Celine , Wicke Felix S. , Rückert Kamiar K. , Schattenberg Jörn M. , Tüscher Oliver , Wild Philipp S. , Münzel Thomas , König Jochem , Lackner Karl J. , Pfeiffer Norbert , Beutel Manfred E. 
Published: August 2024

Abstract
Background
Self-rated physical health (SRPH) is known as an important predictor of mortality. Previous studies mostly used baseline values of self-rated health to predict long-term mortality. The effect of change in self-rated physical health on mortality during the course of aging has rarely been researched. The present study aimed to determine SRPH over time in women and men of an aging population, assess whether and how change in SRPH affects mortality while adjusting for known determinants of mortality, and test effect modification by sex on the relation between course of SRPH and mortality.

Methods
Data of N = 12,423 respondents of the 5-year follow-up of the Gutenberg Health Study (GHS) with participation at the baseline assessment were analysed. All-cause mortality from 5-year follow-up onwards was defined as the primary outcome. SRPH was assessed by a single item. Cox proportional hazards models with adjustment for age, sex, socio-economic status and physical diseases were fitted to assess the predictive power of baseline score and course of SRPH. Additionally, effect modification by sex was assessed.

Results
During a median follow-up period of 7.3 years (quartiles 6.0-8.5 years), 618 (5%) participants died. Overall, 70.9% of the participants indicated good or very good SRPH at baseline (T1) and follow-up (T2), 6.9% rated their SRPH as not so good at T1 and T2, and 0.6% reported bad SRPH at T1 and T2. An improvement of SRPH was indicated by 9.6% and 12.0% indicated deterioration of their SRPH. Change in SRPH added substantial predictive information to the Cox proportional hazards models, when adjusting for relevant covariates. In men, deterioration and constantly bad SRPH were associated with the strongest increase in risk of mortality by 87%, resp. 228%. While improvements increased mortality risk in men (67%), women with an improved SRPH had a lower risk (57%).

Conclusion
A sizeable subgroup of aging participants reported deterioration of SRPH over five years. The association between change of SRPH and mortality is modified by sex. Deterioration of SRPH predicts mortality over baseline-assessment even when adjusted for relevant covariates. SRPH should be assessed regularly as part of an older individual’s health evaluation. Deterioration, constantly bad and improved SRPH should be taken seriously as unfavorable prognostic indicators, the latter only in men.
Tackling gender disparities in energy research: a diagnostic tool for equality in research centres
Authors: Sánchez-López Sara , Poveda-Bautista Rocío , Corona-Sobrino Carmen , Otero-Hermida Paula , García-Melón Mónica 
Published: August 2024

Abstract
Background
In a case study in Spain, the unequal proportion of men and women in a research organization in the energy sector is severe, and long-established dynamics that might determine differences in access to leadership positions and inequalities in research careers are evident. The gender gap in historically masculinized fields, such as energy engineering reflects more than simply the differences in male and female values and personalities. This study seeks to explore the gender gap in energy research centres and to identify barriers that potentially hinder the research careers of women. It proposes the development of a diagnostic tool, based upon indicators, to monitor and evaluate gender roles and inequalities in the management of research centres for identifying and addressing the dynamics and obstacles that hinder women's progress in the energy sector and their potential contribution to the field. This participatory multicriteria-based tool prioritizes the proposed indicators by their influence and importance in the context of energy research and applies it to the monitoring of a specific Spanish energy research centre.

Results
The results are threefold: (i) the methodology is adaptable to different research centres; (ii) the analysis of indicators’ prioritization could lead to recommendations that should be addressed first; (iii) the diagnostic tool used in this in-depth case study of an energy research centre in Spain allowed results to be achieved in terms of gender dynamics. Two indicators stand out as the most relevant in our analysis: gender diversity in leadership positions and uncomplicated application of work–life balance measures. In this case study, the measurement of the first indicator has drawn unsatisfactory results, and the research of the latter is considered still insufficient. In conclusion, this difference becomes a vicious or negative circle for attracting and retaining more women to the research centre. Despite these results, no gender gap seems to be recognized and thus, no measures are being taken to improve the situation.

Conclusions
Comprehensive data and contextualized monitoring are necessary to effectively study and enhance the presence and participation of women in the energy science sector. This approach, combining quantitative and qualitative techniques, is suitable for any research centre that would like to monitor its gender gap, identify potential sources of inequity and address them.
Construction and optimization of ecological spatial network in typical mining cities of the Yellow River Basin: the case study of Shenmu City, Shaanxi
Authors: Sun Weijie , Yu Qiang , Xu Chenglong , Zhao Jikai , Wang Yu , Miao Yulin 
Published: August 2024

Abstract
Background
In resource-based cities, long-term irrational exploitation of resources has caused severe damage to ecosystem functions, mainly manifested in the significant decline of biodiversity, land degradation, water pollution, and the deterioration of air quality. This has led to a significant decline in the cities' sustainable development capabilities. Establishing and optimizing an ecological spatial network (ESN) can promote the effective transmission of material energy and enhance the ecosystem functions, which holds fundamental importance in ensuring the ecological integrity of the region and promoting sustainable urban development. In this study, by combining the ecological environment with the landscape to determine the ecological sources, we constructed the ESN of Shenmu City, a mining city, based on the minimum cumulative resistance (MCR) model, and conducted a correlation analysis between the topological structure of the ESN and the significance of ecosystem functions. Then, the optimization strategy scheme based on ecosystem functions was proposed. Finally, robustness was used to determine the effect before and after optimization.

Results
The results showed that the high-value ecosystem service areas in Shenmu City were predominantly located in the central and western parts, with the highest value in the southeast. There was a strong correlation between the importance of ecosystem functions and the degree and feature vector of ecological nodes.

Conclusions
The ESN can be optimized effectively by adding stepping stone nodes and new corridors. Through the robustness of the optimized ESN, we found that the optimized network has more robust connectivity and stability and can show better recovery ability after ecological function damage. This research presents an effective method for the construction and optimization of the ESN in the mining area and provides a theoretical basis for realizing the sustainability of the mining economy, regional development, and ecological protection in Shenmu City.
Toxoplasma gondii IgG serointensity and cognitive function in bipolar disorder
Authors: Rensch Paul , Postolache Teodor T. , Dalkner Nina , Stross Tatjana , Constantine Niel , Dagdag Aline , Wadhawan Abhishek , Mohyuddin Farooq , Lowry Christopher A. , Joseph Joshua , Birner Armin , Fellendorf Frederike T. , Finner Alexander , Lenger Melanie , Maget Alexander , Painold Annamaria , Queissner Robert , Schmiedhofer Franziska , Smolle Stefan , Tmava-Berisha Adelina , Reininghaus Eva Z. 
Published: August 2024

Abstract
Background
Alongside affective episodes, cognitive dysfunction is a core symptom of bipolar disorder. The intracellular parasite T. gondii has been positively associated with both, the diagnosis of bipolar disorder and poorer cognitive performance, across diagnostic boundaries. This study aims to investigate the association between T. gondii seropositivity, serointensity, and cognitive function in an euthymic sample of bipolar disorder.

Methods
A total of 76 participants with bipolar disorder in remission were tested for T. gondii-specific IgG and IgM antibodies and for cognitive performance using neuropsychological test battery. Cognitive parameters were categorized into three cognitive domains (attention and processing speed, verbal memory, and executive function). Statistical analysis of associations between continuous indicators of cognitive function as dependent variables in relationship to T. gondii, included multivariate analyses of co-variance for seropositivity, and partial correlations with IgG serointensity in IgG seropositives. All analyses were controlled for age and premorbid IQ.

Results
In seropositives (n = 27), verbal memory showed significant inverse partial correlations with IgG antibody levels (short delay free recall (r=–0.539, p = 0.005), long delay free recall (r=–0.423, p = 0.035), and immediate recall sum trial 1–5 (r=–0.399, p = 0.048)). Cognitive function did not differ between IgG seropositive and seronegative individuals in any of the cognitive domains (F (3,70) = 0.327, p = 0.806, n = 76). IgM positives (n = 7) were too few to be analyzed.

Conclusions
This investigation is the first to show an association between T. gondii IgG serointensity and memory function in a well-diagnosed bipolar disorder sample. It adds to the existing literature on associations between latent T. gondii infection and cognition in bipolar disorder, while further research is needed to confirm and expand our findings, eliminate potential sources of bias, and establish cause-effect relationships.
Model for dimensioning borehole heat exchanger applied to mixed-integer-linear-problem (MILP) energy system optimization
Authors: Blanke Tobias , Born Holger , Döring Bernd , Göttsche Joachim , Herrmann Ulf , Frisch Jérôme , van Treeck Christoph 
Published: August 2024

AbstractThis paper introduces three novel approaches to size geothermal energy piles in a MILP, offering fresh perspectives and potential solutions. The research overlooks MILP models that incorporate the sizing of a geothermal borefield. Therefore, this paper presents a new model utilizing a g-function model to regulate the power limits. Geothermal energy is an essential renewable source, particularly for heating and cooling. Complex energy systems, with their diverse sources of heating and cooling and intricate interactions, are crucial for a climate-neutral energy system. This work significantly contributes to the integration of geothermal energy as a vital energy source into the modelling of such complex systems. Borehole heat exchangers help generate heat in low-temperature energy systems. However, optimizing these exchangers using mixed-integer-linear programming (MILP), which only allows for linear equations, is complex. The current research only uses R-C, reservoir, or g-function models for pre-sized borefields. As a result, borehole heat exchangers are often represented by linear factors such as 50 W/m for extraction or injection limits. A breakthrough in the accuracy of borehole heat exchanger sizing has been achieved with the development of a new model, which has been rigorously compared to two simpler models. The geothermal system was configured for three energy systems with varying ground and bore field parameters. The results were then compared with existing geothermal system tools. The new model provides more accurate depth sizing with an error of less than 5 % compared to simpler models with an error higher than 50 %, although it requires more calculation time. The new model can lead to more accurate borefield sizing in MILP applications to optimize energy systems. This new model is especially beneficial for large-scale projects that are highly dependent on borefield size.
Evaluation of anti-aging and antioxidant properties of a new rose variety, Ever-rose
Authors: Han Se Jik , Belousova Polina , Kwon Sangwoo , Jang Jihui , Lee Jun Bae , Kim Hyunjae , You Gayeon , Song Jihyeon , Mok Hyejung , Ha Ho Su , Bae So Jeong , Ha In Jin , Lee Min Young , Kim Kyung Sook 
Published: August 2024

Abstract
Background
Rose flowers contain active ingredients such as flavonoids and volatile oils and are acknowledged to be good natural resources owing to their anti-aging and antioxidant properties. In this study, we develop four new rose varieties (named Ever-rose) that are fragrant, pest resistant, and easy to grow. Subsequently, we evaluate the properties of Ever-rose and its potential for use in anti-aging products.

Methods
The chemical composition of Ever-rose was determined using ultra-high-performance liquid chromatography triple time-of-flight mass spectrometry/mass spectrometry. The antioxidant activity of the Ever-rose extract was evaluated using various assays, including superoxide dismutase activity, 2,2-diphenyl-1-picrylhydrazyl radical-scavenging capacity, and xanthine oxidase activity. The variations in proteolytic matrix metalloproteinase-1 expression, collagen content after ultraviolet (UV) irradiation, and reactive-oxygen-species (ROS) levels after infrared A (IRA) treatment were evaluated. The variations in cell elasticity were assessed via atomic force microscopy.

Results
The petal extracts of Ever-rose (named ER004(P), ER011(P), ER012(P), and ER015(P)) showed good antioxidant activity. They effectively inhibited UV irradiation-induced MMP-1 expression and IRA irradiation-induced increase in mitochondrial ROS levels. Additionally, they inhibited variations in cell shape and elasticity as aging progressed. In particular, ER011(P) demonstrated the best anti-aging and antioxidant effects.

Conclusion
The newly developed Ever-rose showed excellent antioxidant and anti-aging effects. In particular, ER011(P) demonstrated the best properties owing to its high antioxidant content. Hence, it exhibits significant potential as a functional cosmetic ingredient.

Graphical Abstract
Distribution and trend of explosive cyclones over the Southern Ocean and associated atmospheric and oceanic changes during 1980–2020
Authors: Xu Xiaoqi , Liu Jiping , Huang Gang , Ding Yifan 
Published: August 2024

AbstractIn this study, we investigate the climatology and trend of explosive cyclones (ECs) over the Southern Ocean (50oS–70oS) during 1980–2020 by combining a method that is most suited for identifying and tracking cyclones in the Southern Ocean and a latest climate reanalysis. On average, approximately 50 ECs are generated annually over the Southern Ocean, with a significant increasing trend of 2.3 per decade during the studying period. This increasing trend is dominated by the trend of strong ECs, particularly in autumn. We analyze the dynamical and thermodynamical effects associated with multiple deepened strong ECs in autumn over an identified key region in the southern Pacific Ocean sector (155oW–170oW, 50oS–65oS), where the density of the initiation of ECs shows the largest increasing trend in autumn. The composite analysis reveals the general patterns and duration of the effects on the atmosphere, ocean, and sea ice associated with multiple ECs in the southern Pacific Ocean. The results indicate that the deepened strong ECs are associated with significant changes in meridional winds, downward longwave radiation, and sensible and latent heat fluxes. These changes lead to cold sea surface temperature anomalies in the northeast of the key region, reaching a maximum 5–7 days after the EC deepening, and the increased sea ice cover south of the key region, peaking 4–5 days after the EC deepening.
Investigation on environmental factors contributing to bispecific antibody stability and the reversal of self-associated aggregates
Authors: Ingavat Nattha , Dzulkiflie Nuruljannah , Liew Jia Min , Wang Xinhui , Leong Eunice , Loh Han Ping , Ng Say Kong , Yang Yuansheng , Zhang Wei 
Published: August 2024

AbstractBispecific antibodies (bsAbs) hold promises for enhanced therapeutic potential surpassing that of their parental monoclonal antibodies. However, bsAbs pose great challenges in their manufacturing, and one of the common reasons is their susceptibility to aggregation. Building on previous studies demonstrating the functionality and potential manufacturability of Fab-scFv format bsAb, this investigation delved into the impact of environmental factors—such as pH, buffer types, ionic strength, protein concentrations, and temperatures—on its stability and the reversal of its self-associated aggregates. Mildly acidic, low-salt conditions were found optimal, ensuring bsAb stability for 30 days even at elevated temperature of 40 °C. Furthermore, these conditions facilitated the reversal of its self-associated aggregates to monomers during the initial 7-day incubation period. Our findings underscore the robustness and resilience of Fab-scFv format bsAb, further confirming its potential manufacturability despite its current absence as commercial products.
Graphical Abstract
Ictal-onset localization through effective connectivity analysis based on RNN-GC with intracranial EEG signals in patients with epilepsy
Authors: Wang Xiaojia , Liu Yanchao , Yang Chunfeng 
Published: August 2024

AbstractEpilepsy is one of the most common clinical diseases of the nervous system. The occurrence of epilepsy will bring many serious consequences, and some patients with epilepsy will develop drug-resistant epilepsy. Surgery is an effective means to treat this kind of patients, and lesion localization can provide a basis for surgery. The purpose of this study was to explore the functional types and connectivity evolution patterns of relevant regions of the brain during seizures. We used intracranial EEG signals from patients with epilepsy as the research object, and the method used was GRU-GC. The role of the corresponding area of each channel in the seizure process was determined by the introduction of group analysis. The importance of each area was analysed by introducing the betweenness centrality and PageRank centrality. The experimental results show that the classification method based on effective connectivity has high accuracy, and the role of the different regions of the brain could also change during the seizures. The relevant methods in this study have played an important role in preoperative assessment and revealing the functional evolution patterns of various relevant regions of the brain during seizures.
Low-velocity impact response of hybrid core sandwich panels with spring and strut cores filled with resin, silicone, and foam
Authors: Charkaoui Assil , Hassan Noha M. , Bahroun Zied , Ibrahim Mahmoud 
Published: August 2024

AbstractAdvancements in the load-bearing capacity of composite panels open doors to high-performance applications. The integration of additive manufacturing allows for the creation of intricate core designs effortlessly. Hybrid cores, combining structural elements with infill materials, play a crucial role in enhancing panel impact resistance while maintaining its low weight. This study compares sandwich panels incorporating spring and octet strut structural elements infused with different materials—silicon, foam, and epoxy resin—evaluating their energy absorption capabilities. Additive manufacturing is employed to produce these panels with structural elements then subsequently filled with infills. The drop tower test is utilized to experimentally assess panel behavior under low-velocity impact. Design of experiments and statistical analysis are used to examine the influence of core height, impact height, core geometry, and filling type on the damaged area and impactor penetration. Results showed that the strut-based structure performed better than other structures in preventing penetration, with a damaged area reduction from 501.45 to 301.58 m2 compared to the spring core. The addition of foam or silicon reduced the impact damage to the front and the back sheets, with silicon infills proving to be the most effective, reducing penetration by reducing penetration by about 60%. The depth of impact was measured, with results indicating that the truss core displayed the smallest specific depth of penetration. A decision tree model predicted that a sandwich panel with a spring core would have a 100% chance of perforation while a filled core showed a significantly reduced penetration risk.
Surgical and irradiated case of early breast cancer in a patient with Ehlers–Danlos syndrome
Authors: Yamazaki Asumi , Tada Hiroshi , Muroyama Yuki , Yamazaki Yuto , Miyashita Minoru , Harada-Shoji Narumi , Hamanaka Yohei , Ebata Akiko , Sato Miku , Motonari Tokiwa , Yanagaki Mika , Kon Tomomi , Sakamoto Aru , Suzuki Takashi , Ishida Takanori 
Published: August 2024

Abstract
Background
Ehlers–Danlos syndrome (EDS) is a rare inherited connective tissue disease characterized by hyperextensibility of the skin and joints and tissue fragility of the skin and blood vessels, Vascular EDS is the most severe form of EDS, with abnormal arterial fragility. There have been no reports of breast cancer occurring in patients with vascular EDS. Here, we report here a very rare case of breast cancer in a patient with vascular EDS.

Case presentation
A 46-year-old woman with vascular EDS underwent partial left mastectomy and sentinel lymph node biopsy for left breast cancer (cStage 0) detected by medical examination. The final pathological diagnosis was invasive ductal carcinoma of the breast (pStage IA) [hormone receptor-positive, HER2 score 2 equivocal (FISH-positive), Ki-67LI 18%, luminal-HER2 type]. BluePrint was submitted as an aid in determining the postoperative treatment strategy, BluePrint Molecular Subtype HER2-type. However, the 10-year breast cancer mortality risk using Predict was low (5%). After consultation with the patient, the decision was made to administer postoperative radiation to the preserved breast along with hormone therapy only. There was no delay in postoperative wound healing, and the patient was free of metastatic recurrence for 9 months after surgery.

Conclusion
We performed surgery, postoperative radiotherapy, and hormonal therapy in a breast cancer patient with vascular EDS without major complications.
‘Firm but fair’? Migrant children’s rights through dramaturgy and nation branding in Norway and the UK
Authors: Prabhat Devyani , Seeberg Marie Louise 
Published: August 2024

AbstractApplying nation branding literature and the work of Erving Goffman on dramaturgy to the situation of asylum-seeking children in Norway and in the UK, this paper develops a comparative framework for understanding why child rights appear to be de-prioritised in the current climate of ‘migration control’. The paper identifies historically grounded differential approaches towards child rights and children in the two countries, which currently appear to merge into a common trajectory of migration control, framed in terms of national security and economic productivity. It explores similar tensions in both countries between the discourses of national migration management on the one hand and children's welfare and rights on the other. It finds that universal rights which should protect the welfare of all children are limited and fragmented by ideas of nationalism and foreignness. Despite a more robust legal framework for child rights, Norway is on a similar pathway as the UK; a worrying indictment of how nations fulfil their obligations towards children.