bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chrystus – Król Miłosierdzia
Authors: Szczurek Jan D. 
Published: October 2015

Apostolska Grupa Miłosierdzia Bożego popularyzuje kult Chrystusa – Króla Miłosierdzia. Tytuł „Król Miłosierdzia” występuje w Dzienniczku św. Siostry Faustyny Kowalskiej (Dz. 83; 1146; por. 378). Artykuł poświęcony jest poszukiwaniu odpowiedzi na pytanie o stosunek kultu miłosierdzia Bożego do kultu Króla Miłosierdzia. Odpowiedź streszcza się w zdaniu: kult miłosierdzia Bożego jest trynitarny, kult Króla Miłosierdzia jest chrystologiczny i podkreśla godność królewską Chrystusa, a tym samym także Jego człowieczeństwo.
PORTAL AND ARTERIAL FLUSHING WITH HTK AND TACROLIMUS CAN ATTENUATE THE INCIDENCE OF EARLY LIVER ALLOGRAFT DYSFUNCTION
Authors: Shcherba A. E. , Korotkov S. V. , Efimov D. Yu. , Minou A. F. , Lebedz O. A. , Karytka A. A. , Dzyadzko A. M. , Rummo O. O. 
Published: October 2015

It was shown that Tacrolimus (Tac) can suppress infl ammation and immune response involved in liver ischemia-reperfusion injury (IRI) (Kristo I., Transpl Int., 2011). Aim. We hypothesize that back-table arterial and portal liver perfusion with Tac can infl uence the incidence and severity of early allograft dysfunction (EAD). A prospective randomized study was conducted (ClinicalTrials.gov Identifi er: NCT01887171).Materials and methods.Criteria of the inclusion: First liver transplantation from DBD donor with sequential portal-arterial reperfusion. At back-table portal vein and hepatic artery were perfused each by 500 ml of HTK solution containing 20 ng/ml Tac during 10–15 min followed by portal fl ushing with 200 ml 5% solution of Albumin containing 20 ng/ml Tac and by resting of liver in effl uent. No Tac was added in the control group. Primary Outcome: EAD (Olthoff KM, et al. Liver Transpl. 2010) and severe EAD (P.R.Salvalaggio, et al. Transpl. Proceedings, 2012).Results.No difference was found between groups (main vs. control) in terms of MELD (16 vs. 16), steatosis (10 vs. 10%), ballooning (45 vs. 40%) of liver grafts, recipient age (50 vs. 50 y.o.), warm ischemia time (50 vs.50 min) and total ischemia time (482.5 vs. 485.0 min). Median donor age was higher in the main group (44.5 vs. 39.0 y.o.). The overall rate of EAD was 27.9%. EAD rate was signifi cantly lower in the main group (6/43 vs. 18/43; p = 0.003). The rate of moderate-to-severe EAD was lower in the main group (1/43 vs. 10/43; p = 0.009). The median levels of AST and ALT in 24 h after reperfusion were signifi cantly lower in the intervention group (1004 vs. 1596; p = 0.03 and 449 vs. 759; p = 0.057).Conclusion.Portal and arterial back-table liver perfusion with HTK solution with Tacrolimus may contribute to lower EAD incidence and severity.
IN VITRO INVESTIGATION OF THE TRANSPLANTATION PROSPECTS OF MULTICELLULAR SPHEROID MICROAGGREGATES OF DONOR RETINAL PIGMENT EPITHELIUM
Authors: Borzenok S. A. , Popov I. A. , Saburina I. N. , Arbukhanova P. M. 
Published: October 2015

Aim. To study in experiment the criteria for transplantability of multicellular spheroid microaggregates of retinal pigment epithelium (RPE), prepared by the method of 3D cell culture. Materials and Methods. 11 donor eyes (6 of adrenaline index «A», 5 of index «B») were used as a source of RPE cell cultures (group «A» – 6 cultures, group «B» – 5 cultures), of which over 2000 RPE spheroids were obtained by the method of three-dimensional cell culture. 1760 spheroids of them were selected for transplantability investigation (960 – group «A», 800 – group «B»). Among the selected spheroids were equal numbers of spheroids of different morphology («smooth» and «rough») and of the initial cell seeding number (500, 1000, 5000, 25 000, 125 000 cells per hanging drop). We were taking out 12 spheroids of group «A» and 10 spheroids of group «B» of the 3D culture in terms of 7, 14, 21, 28 days of 3D culture to assess their viability. We were transferring the same number of spheroids in the same terms from 3D to 2D culture conditions to assess their adhesive properties. Viability of cells within spheroids was determined using the Trypan blue exclusion. The presence or absence of adhesion was determined by microscopic observation.Results. «Smooth» spheroids of 7 and 14 days of pretransplantation cultivation and derived from hanging drops containing 500 and 1000 cells showed the highest transplantability (cell viability varied from 0.83 ± 0.38 to 0.94 ± 0.24, a 100% adhesion). «Rough» spheroids were untransplantable in all variants, despite their partial preservation of viability (in comparison to “smooth” ones p < 0.05). 21 and 28 days of pretransplantation culturing and high cell seeding numbers signifi cantly lowered transplantability of obtained spheroids (p > 0.05 for low cell numbers, p < 0.05 for the high ones). Differences in adrenaline indexes A and B of donor eyes which were the primary sources of cellular material had no effect (p > 0.05) on resulting spheroids transplantability.Conclusion. Among RPE spheroids obtained by our method the spheroids cultivated in a 3D environment for 7 to 14 days prior to transplantation and derived from hanging drops containing 500 and 1000 RPE cells showed the highest transplantability.
TREATMENT OF HEPATITIS C WITHOUT INTERFERON IN PATIENTS UNDERGOING LIVER TRANSPLANTATION
Authors: Khubutia M. Sh. , Syutkin V. E. 
Published: October 2015

This review contains analysis of current approaches to HCV treatment in liver transplant recipients. The authors explore key limitations associated with the usage of available treatment options and benefi ts related to the implementation of IFN-free regimens. The review summarizes results of published up-to-date studies on the usage of direct antiviral agents after liver transplantation.
A Prospective Multicenter Study Evaluating Secondary Adrenal Suppression After Antiemetic Dexamethasone Therapy in Cancer Patients Receiving Chemotherapy: A Korean South West Oncology Group Study
Authors: Han Hye Sook , Park Ji Chan , Park Suk Young , Lee Kyu Taek , Bae Sang Byung , Kim Han Jo , Kim Samyoung , Yun Hwan Jung , Bae Woo Kyun , Shim Hyun-Jeong , Hwang Jun-Eul , Cho Sang-Hee , Park Moo-Rim , Shim Hyeok , Kwon Jihyun , Choi Moon Ki , Kim Seung Taik , Lee Ki Hyeong 
Published: October 2015

Abstract

Background.
In a previous pilot study, adrenal suppression was found to be common after antiemetic dexamethasone therapy in cancer patients. The objective of this large prospective multicenter study was to confirm the incidence and factors associated with secondary adrenal suppression related to antiemetic dexamethasone therapy in cancer patients receiving chemotherapy.

Methods.
Chemotherapy-naïve patients who were scheduled to receive at least three cycles of highly or moderately emetogenic chemotherapy with dexamethasone as an antiemetic were enrolled. Patients with a suppressed adrenal response before chemotherapy or those administered corticosteroids within 6 months of enrollment in the study were excluded.

Results.
Between October 2010 and August 2014, 481 patients receiving chemotherapy underwent the rapid adrenocorticotropic hormone (ACTH) stimulation test to assess eligibility; 350 of these patients were included in the final analysis. Fifty-six patients (16.0%) showed a suppressed adrenal response in the rapid ACTH stimulation test at 3 or 6 months after the start of the first chemotherapy. The incidence of adrenal suppression was affected by age, performance status, stage, and use of megestrol acetate in univariate analysis. Multivariate analysis revealed that secondary adrenal suppression associated with antiemetic dexamethasone therapy was significantly associated with megestrol acetate treatment (odds ratio: 3.06; 95% confidence interval: 1.60 to 5.86; p &lt; .001).

Conclusion.
This large prospective study indicates that approximately 15% of cancer patients receiving chemotherapy with a normal adrenal response show suppressed adrenal responses after antiemetic dexamethasone therapy. This result was particularly significant for patients cotreated with megestrol acetate.
Avaliação em larga escala em municípios brasileiros: o que dizem os números?
Authors: Bauer Adriana , Pimenta Claudia Oliveira , Neto João Luiz Horta , Sousa Sandra Zákia Lian 
Published: October 2015

O artigo, que se organiza em quatro seções, apresenta resultados de pesquisa que teve por objetivos mapear e caracterizar iniciativas relacionadas às avaliações em larga escala em desenvolvimento nos municípios brasileiros. Inicialmente, expõe-se uma síntese de estudos já produzidos sobre a temática e, em seguida, são explicitados os procedimentos metodológicos do estudo. Na terceira seção, discutem-se resultados obtidos na fase preliminar do survey, que abarcam manifestações obtidas de 4.309 municípios. Por fim, são apontadas conclusões acerca de concepções presentes nas avaliações propostas pelos municípios e dos usos dos resultados que as gestões desses entes federados fazem das diversas avaliações existentes, que evidenciam a consolidação da avaliação em larga escala como instrumento de gestão educacional nas municipalidades.
Molecular Regulators of Metabolism and Cardiometabolic Disease
Authors: Sukmawati Indriyanti Rafi , Wijaya Andi 
Published: October 2015

BACKGROUND: The mechanisms that are responsible for energy management in cells in an organism require a complex network of transcription of factors and cofactors.CONTENT: All living system must maintain a tight equilibrium between energy intake, storage and expenditure for optimal performance. This tight equilibrium must be both robust and flexible to allow for adaptation to every situation such as exercise or rest and famine or feast. Organisms rely on finely tuned and complex signaling network to confront with all possibilities. Metabolic imbalance can cause dysfunction and pertubation of these networks, which if uncorrected will induce disease such as obesity and diabetes mellitus.SUMMARY: During the last decades the understanding of the transcriptional regulation of diverse metabolic pathways has contributed to the elucidation of mechanisms of metabolic control and to a better knowledge of the pathogenesis of metabolic diseases. KEYWORDS: AMPK, SIRT1, PGC-1α, FGF21, mTORC1
The Role of Signal Transducer and Activator of Transcription 3 (STAT3) in Tumor Immunity
Authors: Adhika Oeij Anindita , Shahib M Nurhalim 
Published: October 2015

BACKGROUND: Inflammation is a key component of the tumor microenvironment. Cancer-associated inflammation is marked by the presence of specific inflammatory cells and inflammatory mediators. Moreover, immune cells in the tumor microenvironment not only fail to mount an effective antitumor immune response, but also interact intimately with the tumor cells to actively promote oncogenesis.CONTENT: Their roles in regulating cytokine-dependent inflammation and immunity make the signal transducer and activator of transcription (STAT) proteins critical players in determining whether immune responses in tumor microenvironment promote or inhibit cancer. Recent evidence suggests a crucial role for STAT family proteins, especially STAT3 (signal transducer and activator of transcription 3), which is a point of convergence for numerous oncogenic signaling pathways, in selectively inducing and maintaining a procarcinogenic inflammatory microenvironment, both at the initiation of malignant transformation and during cancer progression. The persistent activation of STAT3 increases tumor cell proliferation, survival, and invasion while supressing antitumor immunity. SUMMARY: STAT3 signaling pathway constitutes a potential preventive and therapeutic target for cancer immunotherapy. KEYWORDS: STAT3, inflammation, tumor microenvironment, cancer immunotherapy
C-Reactive Protein and Matrix Metalloproteinase-9 are Associated with Outcome of Ischemic Stroke
Authors: Surjawan Yenny , As'ad Suryani , Ranakusuma Teguh A S , Wijaya Andi 
Published: October 2015

BACKGROUND: C-Reactive protein (CRP) and matrix metalloproteinase (MMP)-9 are inflammatory mediators that are often associated with the evolution of stroke. In this study, we aimed to find out whether concentration of these biomarkers were associated with the severity of discharge National Institute of Health Stroke Scale (NIHSS) in ischemic stroke patient.METHODS: In prospective stody, we involved 143 ischemic stroke patient who were admitted to hospital not more than 72 hours after the onset and who met the criteria. The concentration of CRP was assessed by High Sensitivity CRP reagent from Siemens and the concentration of MMP-9 was measure with Quantikine Human MMP-9 (total) Immunoassay from R&D. The outcome of stroke was determined by NIHSS score at discharge.RESULTS: There was a significant correlation between the CRP level and the severity of NIHSS at discharge (r = 0.288, p = 0.000). Subjects with intermediate/high level of CRP had a higher probability to have a moderate or even severe NIHSS (OR = 1.7, p = 0.004). Subjects with high MMP level showed a higher probability to have a severe NIHSS. CONCLUSION: The measurement of CRP and MMP-9 at 48-72 hours after stroke onset were associated with the severity of ischemic stroke based on NIHSS score at discharge. KEYWORDS: inflammation, CRP, MMP-9, discharged NIHSS
Isolation of nuclear microsatellites in the African timber tree Lophira alata (Ochnaceae) and cross‐amplification in L. lanceolata
Authors: Piñeiro Rosalía , Staquet Adrien , Hardy Olivier J. 
Published: October 2015

Premise of the study:Microsatellite markers were isolated in the rainforest tree Lophira alata (Ochnaceae), an important timber tree from Central Africa, and cross‐amplified on its savannah counterpart, L. lanceolata.Methods and Results:From a microsatellite‐enriched library sequenced on a 454 GS FLX platform, 13 primer combinations were identified. Amplification was optimized in two multiplex reactions. The primers amplified di‐ and trinucelotide repeats, with two to seven alleles per locus. Eleven primers also amplified in L. lanceolata.Conclusions:Microsatellite primers developed for the genus Lophira displayed sufficient variation to investigate hybridization between congeneric species in the rainforest–savannah transition.
Characterization of 12 polymorphic SSR markers in Veronica subsect. Pentasepalae (Plantaginaceae) and cross‐amplification in 10 other subgenera
Authors: López‐González Noemí , Mayland‐Quellhorst Eike , Pinto‐Carrasco Daniel , Martínez‐Ortega M. Montserrat 
Published: October 2015

Premise of the study:Microsatellite primers were developed in the perennial herbs of the diploid‐polyploid complex Veronica subsect. Pentasepalae (Plantaginaceae) to investigate the role that hybridization has played in the evolution of the group, which includes several endangered species.Methods and Results:Twelve pairs of primers leading to polymorphic and readable markers were identified and optimized from V. jacquinii and V. orbiculata using a microsatellite‐enriched library method and 454 GS‐FLX technique. The set of primers amplified dinucleotide to pentanucleotide repeats, and the number of alleles per locus ranged from one to six, one to 11, and one to nine for V. orsiniana, V. javalambrensis, and V. rosea, respectively. Transferability analyses were performed in 20 species corresponding to 10 different subgenera.Conclusions:These results indicate the utility of the newly developed microsatellites across Veronica subsect. Pentasepalae, which will help in the study of gene flow patterns and genetic structure.
Influence on Visual Quality of Intraoperative Orientation of Asymmetric Intraocular Lenses
Authors: Bonaque-González Sergio , Ríos Susana , Amigó Alfredo , López-Gil Norberto 
Published: October 2015

PURPOSE:
To evaluate visual quality when changing the intraocular orientation of the Lentis Mplus LS-312MF nonrotational symmetric +3.00 diopters aspheric multifocal intraocular lens ([IOL] Oculentis GmbH, Berlin, Germany) in normal eyes.

METHODS:
An artificial eye was used to measure the in vitro wavefront of the IOL. The corneal topography of 20 healthy patients was obtained. For each eye, a computational analysis simulated the implantation of the IOL. The modulation transfer function (MTF) and an image quality parameter (visually modulated transfer function [VSMTF] metric) were calculated for a 5.0-mm pupil and for three conditions: distance, intermediate, and near vision. The procedure was repeated for each eye after a rotation of the IOL with respect to the cornea from 0° to 360° in 1° steps.

RESULTS:
Statistical analysis showed significant differences in mean VSMTF values between orientations for distance vision. Optimal orientation of the IOL (different for each eye) showed a mean improvement of 58% ± 19% (range: 20% to 121%) in VSMTF values with respect to the worst possible orientation. For these orientations, intermediate and near vision quality were statistically indistinguishable. The MTFs were different between orientations, showing a mean difference of approximately 5 cycles per degree in the maximum spatial frequencies that can be transferred between the best and the worst orientations for distance vision.

CONCLUSIONS:
The results suggest that implantation of this nonrotational symmetric IOL should improve visual outcomes if it is oriented to coincide with a customized meridian. A simple, practical method is proposed to find an approximation to the angle that an Mplus IOL should be inserted.

[
J Refract Surg.
2015;31(10):651–656.]
Existence of Hilbert Cusp Forms with Non-vanishingL-values
Authors: Sugiyama Shingo , Tsuzuki Masao 
Published: October 2015

AbstractWe develop a derivative version of the relative trace formula on PGL(2) studied in our previous work, and derive an asymptotic formula of an average of central values (derivatives) of automorphicL-functions for Hilbert cusp forms. As an application, we prove the existence of Hilbert cusp forms with non-vanishing central values (derivatives) such that the absolute degrees of their Hecke fields are arbitrarily large.
“That swevene hath Daniel unloke”:
Authors: Harrington Marjorie 
Published: October 2015

Abstract
This article contrasts Chaucer's attitude toward dream visions and the Somniale tradition with English and Latin Somniale works in two of the Harley scribe's manuscripts: London, British Library MSS Harley 2253 and Royal 12.C.xii. It includes an edition of the Royal Somniale Danielis, here edited and translated for the first time. I demonstrate that—in contrast to Chaucer's skepticism—the Harley scribe viewed the Somniale tradition as a valuable source of knowledge worthy of transmission into English. The vast gap between these two figures' approaches to dream interpretation reveals that fourteenth-century attitudes toward texts that bridge the practical/devotional divide were not homogeneous, and that Chaucer's characteristic ambivalence toward and manipulation of dream genres should not be taken as representative.
“Ane Doolie Sessoun” and “Ane Cairfull Dyte”:
Authors: Dunai Amber 
Published: October 2015

Abstract
This article reads the narrator of Robert Henryson's Testament of Cresseid as a central character alongside the titular heroine of the piece. It locates similarities between Cresseid and her narrator in their unlawful sexuality, physical deterioration, and consequential exclusion from the religion of love. However, while Cresseid is shown to undergo a genuine personal transformation by the end of Testament, the narrator's erroneous reading of the story's lesson suggests that he has missed the true moral point, which advocates for the abandonment of worldly pleasures in favor of eternal qualities. Parallels between the spiritually rehabilitative qualities of leprosy and old age indicate that his moral progress may be ongoing, although at the end of the poem he still resembles Cresseid at the stage of complaint rather than repentance.
For Want of a Better Estimate, Let’s Call It the Year 2000: The Twilight Zone and the Aural Conception of a Dystopian Future
Authors: Wissner Reba A. 
Published: October 2015

Abstract
This paper examines the aural conceptions of futuristic dystopias in episodes of The Twilight Zone, focusing on one specific episode, season five’s “Number Twelve Looks Just Like You.” I examine how the music director of CBS conceived of the future, aurally representing these episodes as having an affinity with the premise of Brave New World by reusing its radio score by Bernard Herrmann. As a result, I will explore the use of the radio score in the episode and the ways in which dystopian futures were aurally represented in the series.
Lydia Maria Child: Abolitionism and the New England Spirit
Authors: Duran Jane 
Published: October 2015

Abstract
lydia maria child (1802–1880) was one of the best-known women intellectuals of the nineteenth century on the American scene, and yet her name is not often heard today. Although it might seem gratuitous to attempt to label a thinker—and, in some cases, not only unnecessary, but demeaning—there is ample reason to think that Child can be called a transcendentalist, as well as an early abolitionist and feminist. In any case, the independent and very forward-looking work of this woman thinker of her time, it can be argued, deserves further consideration and is not without philosophical import.
Reply to Joshua Anderson
Authors: Aikin Scott F. , Talisse Robert B. 
Published: October 2015

Abstract
We are pleased to find that our 2005 paper “Why Pragmatists Cannot Be Pluralists” (Talisse and Aikin) continues to draw critical attention. It seems to us that despite the many responses to our paper, its central challenge has not been met. That challenge is for pragmatists to articulate a genuine pluralism that is consistent with their broader commitments. Unfortunately, much of the wrangling over our paper has aimed to capture the word “pluralism” for pragmatist deployment; little has been done to clarify what that term means when pragmatists use it. This is pragmatically unacceptable. Hence there is work to be done, and we are happy to revisit the issues.
Deconstructivist Interaction Design: Interrogating Expression and Form
Authors: Murer Martin , Fuchsberger Verena , Tscheligi Manfred 
Published: October 2015

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>In this paper, we propose </span><span>deconstructivist interaction design </span><span>in order to facilitate the differentiation of an expressional vo- cabulary in interaction design. Based on examples that illus- trate how interaction design critically explores (i.e., decon- structs) its own expressional repertoire, we argue that there are commonalities with deconstructivist phases in related de- sign disciplines to learn from. Therefore, we draw on the role and characteristics of deconstructivism in the history of archi- tecture, graphic design, and fashion. Afterwards, we reflect on how interaction design is already a means of deconstruc- tion (e.g., in critical design). Finally, we discuss the potential of deconstructivism for form-giving practices, resulting in a proposal to extend interaction design’s expressional vocabu- lary of giving form to computational material by substantiat- ing a deconstructivist perspective. </span></p></div></div></div>