bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dapagliflozin in heart failure and type 2 diabetes: Efficacy, cardiac and renal effects, safety
Authors: Yu Pei-Ling , Yu You , Li Shuang , Mu Bai-Chen , Nan Ming-Hua , Pang Min 
Published: July 2024

BACKGROUND
Heart failure (HF), especially HF with reduced ejection fraction (HFrEF), presents complex challenges, particularly in the aging population where it often coexists with type 2 diabetes mellitus (T2DM).
AIM
To analyze the effect of dapagliflozin treatment on cardiac, renal function, and safety in patients with HFrEF combined with T2DM.
METHODS
Patients with T2DM complicated with HFrEF who underwent treatment in our hospital from February 2018 to March 2023 were retrospectively analyzed as the subjects of this study. The propensity score matching method was used, and a total of 102 eligible samples were scaled. The clinical efficacy of the two groups was evaluated at the end of the treatment, comparing the results of blood glucose, insulin, cardiac function, markers of myocardial injury, renal function indexes, and 6-min walk test (6MWT) before and after the treatment. We compared the occurrence of adverse effects on the treatment process of the two groups of patients. The incidence of adverse outcomes in patients within six months of treatment was counted.
RESULTS
The overall clinical efficacy rate of patients in the study group was significantly higher than that of patients in the control group (P = 0.013). After treatment, the pancreatic beta-cell function index, left ventricular ejection fraction, and glomerular filtration rate of patients in the study group were significantly higher than control group (P < 0.001), while their fasting plasma glucose, 2-h postprandial glucose, glycosylated hemoglobin, insulin resistance index, left ventricular end-systolic diameter, left ventricular end-diastolic diameter, cardiac troponin I, creatine kinase-MB, N-terminal pro b-type natriuretic peptide, serum creatinine, and blood urea nitrogen were significantly lower than those of the control group. After treatment, patients in the study group had a significantly higher 6MWT than those in the control group (P < 0.001). Hypoglycemic reaction (P = 0.647), urinary tract infection (P = 0.558), gastrointestinal adverse effect (P = 0.307), respiratory disturbance (P = 0.558), and angioedema (P = 0.647) were not statistically different. There was no significant difference between the incidence of adverse outcomes between the two groups (P = 0.250).
CONCLUSION
Dapagliflozin significantly enhances clinical efficacy, cardiac and renal function, and ambulatory capacity in patients with HFrEF and T2DM without an increased risk of adverse effects or outcomes.
Functional lumen imaging probe use in a high-volume practice: Practical and technical implications
Authors: Jiang Yan , Vazquez-Reyes Raul , Kamal Afrin , Zikos Thomas , Triadafilopoulos George , Clarke John O 
Published: July 2024

BACKGROUND
The functional lumen imaging probe (FLIP) is a Food and Drug Administration approved tool to aid the diagnosis and management of esophageal disorders. However, widespread adoption of FLIP remains limited and its utility in high-volume practices remains unclear.
AIM
To analyze large sample data on clinical use of FLIP and provide insight on several technical aspects when performing FLIP.
METHODS
We conducted a retrospective comparative and descriptive analysis of FLIP procedures performed by a single provider at an academic medical center. There was a total of 398 FLIP procedures identified. Patient medical records were reviewed and data regarding demographics and procedural details were collected. Statistical tests, including chi-squared, t -test, and multivariable logistic and linear regression, were performed.
RESULTS
There was an increase in FLIP cases with each successive time period of 13 months (n = 68, 146, 184, respectively) with notable rises specifically for indications of dysphagia and gastroesophageal reflux disease. There was a shift toward use of the longer FLIP balloon catheter for diagnostic purposes (overall 70.4% vs 29.6%, P < 0.01). Many cases (42.8%) were performed in conjunction with other diagnostics/interventions, such as dilation and wireless pH probe placement. Procedures were nearly equally performed with anesthesia vs moderate sedation (51.4% anesthesia), with no major complications. Patients who had anesthesia were less likely to have recurrent antegrade contractions [odds ratio (OR) = 0.4, 95%CI: 0.3-0.8] and were also more likely to have absent contractility (OR = 2.4, 95%CI: 1.3-4.4).
CONCLUSION
FLIP cases have increased in our practice with expanding indications for its use. Given limited normative data, providers should be aware of several potential technical issues, including the possible impact of sedation choice when assessing esophageal motility patterns.
Endoscopic pancreatogastric anastomosis in the treatment of symptoms associated with inflammatory diseases of the pancreas
Authors: Jagielski Mateusz , Bella Eryk , Jackowski Marek 
Published: July 2024

BACKGROUND
The outflow of pancreatic juice into the duodenum is often impaired in pancreatic inflammatory diseases. The basis of interventional treatment in these cases is anatomical transpapillary access of the main pancreatic duct during endoscopic retrograde cholangiopancreatography (ERCP), which ensures the physiological outflow of pancreatic juice into the lumen of the digestive tract. However, in some patients, anatomical changes prevent transpapillary drainage of the main pancreatic duct. Surgery is the treatment of choice in such cases.
AIM
To evaluate the effectiveness and safety of endoscopic pancreaticogastrostomy under endoscopic ultrasound (EUS) guidance.
METHODS
Retrospective analysis of treatment outcomes of all patients with acute or chronic pancreatitis who underwent endoscopic pancreatogastric anastomosis under EUS guidance in 2018-2023 at the Department of General, Gastroenterological and Oncological Surgery, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland.
RESULTS
In 9 patients [7 men, 2 women; mean age 53.45 (36-66) years], endoscopic pancreatogastric anastomosis under EUS guidance was performed because of the lack of transpapillary access during ERCP. Narrowing of the main pancreatic duct at the head of the pancreas was observed in 4/9 patients (44.44%). Pancreatic fragmentation (disconnected pancreatic duct syndrome) was diagnosed in 3/9 patients (33.33%). In 2/9 patients (22.22%), narrowing of the pancreatoenteric anastomosis was observed after pancreaticoduodenectomy. Technical success of endoscopic pancreaticogastrostomy was observed in 8/9 patients (88.89%). Endotherapeutic complications were observed in 2/9 patients (22.22%). Clinical success was achieved in 8/9 patients (88.89%). The mean follow-up period was 451 (42-988) d. Long-term success of endoscopic pancreatogastric anastomosis was achieved in 7/9 patients (77.78%).
CONCLUSION
Endoscopic pancreaticogastrostomy under EUS guidance is an effective and safe treatment method, especially in the absence of transpapillary access to the main pancreatic duct.
Optimalisasi Kelincahan melalui Penerapan Olahraga Tradisional Menjala Ikan
Authors: Nuhad Hanin  , Anna Noordia  
Published: July 2024

Perkembangan motorik kasar sangatlah penting bagi anak guna mendukung perkembangan tubuh yang sehat, kuat, dan dapat melakukan apa saja. Kelincahan adalah aspek yang sangat penting untuk ditingkatkan. Salah satu permainan olahraga tradisional yang didalamnya mengutamakan kelincahan adalah permainan menjala ikan. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh olahraga tradisional permainan menjala ikan terhadap kelincahan siswa putra kelas 5 sekolah dasar. Metode yang peneliti gunakan adalah deskriptif secara kuantitatif menggunakan pendekatan kuasi eksperimen dengan design penelitian pretest-posttest control group design. Penelitian ini melibatkan 18 siswa kelas 5 putra. Metode pengambilan sampel menerapkan total sampling. Sampel untuk penelitian ini yaitu siswa laki-laki sd kelas 5 . Dengan menggunakan teknik pengumpulan data tes illinois agility. Hasil dari penelitian menunjukkan bahwa permainan olahraga tradisional menjala ikan berpengaruh dalam meningkatkan kelincahan siswa putra kelas 5 sekolah dasar di SDN Tanjungharjo 1 Kecamatan Kapas Kabupaten Bojonegoro.
Analisis Stress Level Terhadap Resiko Cedera Olahraga pada Mahasiswa Atlet
Authors: Muhamad Hilal Luthfi  , Herman Subarjah  , Ahmad Hamidi  
Published: July 2024

Stres menjadi hal umum bagi mahasiswa atlet, karena mahasiswa memiliki ketidakstabilan yang cukup rentan terhadap stres berlebih dan kecemasan. Permasalahan pada penelitian ini yaitu bagaimana tingkatan stres berdampak pada resiko cedera berulang, karena cedera olahraga dapat menjadi hal yang serius dan berdampak negatif bagi atlet. Untuk mengetahui bagaimana kedua variabel berhubungan satu sama lain, teknik korelasional kuantitatif digunakan. Sampel terdiri dari 22 mahasiswa atlet Universitas Pendidikan Indonesia, yang dipilih berdasarkan populasi dan kriteria khusus. Untuk memecahkan masalah kuesioner digunakan dalam penelitian ini. Perceived Stress Scale (PSS) digunakan agar mengetahui tingkatan stres pada mahasiswa atlet, kuesioner ini memiliki nilai Alpha Cronbach 0,801 yang berarti memiliki nilai realibilitas yang tinggi. Sedangkan Re-Injury Anxiety Inventory (RIAI) memiliki nilai Alpha Cronbach 0,959 yang berarti memiliki nilai realibilitas yang sempurna. Data diolah menggunakan SPSS versi 25 dengan Uji Regresi untuk mengetahui pengaruh antara dua variabel tersebut. Hasil dari penelitian ini menunjukkan bahwa tingkatan stres memiliki pengaruh terhadap resiko cedera berulang pada mahasiswa atlet. Dapat dibuktikan dengan nilai signifikansi 0,003 yang berarti jika nilai Sig < 0,05 maka data yang dianalisis memiliki pengaruh.
Digitalization of education as a cultural value
Authors: Udzhukhu I. A. , Tuguz F. A. , Dvoynikova E. S. 
Published: July 2024

Education is an indicator of global transformations taking place in the world and a source of social progress. The relevance of the research is due to the emerging scientific contradiction, which requires resolution, between the active process of digitalization of all spheres of human life and the potential capabilities of the educational institution to effectively implement digital services in the educational process. The problem of the research is to find an answer to the question: what are the main vectors of digitalization of education in modern conditions as a cultural value? The goal of the research is to reveal key directions of digitalization of education as basic guidelines for its quality in modern conditions. The research methods used are analysis, deduction, generalization, survey.The Research results: the dominant directions of the digitalization process of modern education have been revealed and the key trends in the digital transformation of education have been identified; the range of ICT within the framework of academic disciplines in universities in physical education and sports has been argued; factors that impede the spread of digital educational technologies have been systematized.Key conclusions: the dominant directions of the process of digitalization of education are introduction of digital programs for monitoring student progress, transfer of information, development of online learning, systems for universal student identification, design of digital models of educational institutions. ICT used in physical education and sports classes are an interactive whiteboard, a multimedia projector, electronic textbooks, preparation and demonstration of videos of the training process, etc. Factors hindering the spread of digital educational technologies are the demand for the development of special teaching materials for methodological support of the use of digital resources in the educational process; teachers’ conservatism towards digital innovations, etc.
Interaction of the population with authorities using digital technologies: sociological analysis
Authors: Kirzhinova S. A. , Nakhusheva M. S. , Tuguz Z. Y. 
Published: July 2024

In the modern world new formats of civil participation for the population are emerging, associated with the use of innovative technologies. The problem of introducing and developing digital services into the public administration system at all levels of government is urgent. Experts argue that digitalization will ensure an increase in the level of efficiency in the provision of public services to the population. The problematic field of research is the level of involvement of the population in interaction with government structures in the digital space. Mastering the information environment requires certain competencies that are not developed immediately. The speed of mastering such competencies depends on many factors, including the understanding of the need for their constant use. The goal of the research is to determine the attitude of the regional population towards digital technologies used for interaction between citizens and government agencies.Today, comprehensive sociological research on this topic is required. When working on a scientific article, methods of sociocultural analysis, document analysis, and empirical collection of primary information in the form of a survey were used. The main conclusion is that for the effective development of digital interaction between the population and the authorities, it is necessary not only to introduce, but also to increase the level of trust of citizens in the digital resources of the state.
On some aspects of studying the topic «Russia: trials and heroes» within the framework of the discipline «Fundamentals of Russian Statehood»
Authors: Volkov V. V. , Mаryeva M. V. 
Published: July 2024

The article considers the issue of teaching the new course «Fundamentals of Russian Statehood», which has been introduced everywhere into the programs of universities in the country only since 2023, which determines its relevance. The authors are trying to solve the problem: how to awaken a sense of patriotism in young people, convey to them the values of Russian civilization and do this in a way that does not cause rejection or resistance?The goal of the research is to find a theoretical and methodological basis for sensitive, but at the same time effective teaching of the discipline «Fundamentals of Russian Statehood» and to demonstrate the chosen pedagogical strategy using the example of studying the topic «Russia: Trials and Heroes».The authors of the article, using methods of semantic and structural analysis, have formed an ideological framework and set the logic for selecting material, which allows them to provide the necessary information within the chosen topic in a targeted and orderly manner.The result of the research was methodological recommendations and materials for studying the topic «Russia: trials and heroes». In order to avoid a moralizing tone and excessive pathos, it has been proposed to adhere to such pedagogical principles and techniques as focusing on dialogue, relying on previously formed knowledge and ideas, searching for connections between this topic and modernity and professional interests that are relevant for certain groups of students.The Conclusions. The article has a clear practical focus. It presents methodological developments, including, among other things, a logically structured plan and specific tasks on the topic «Russia: trials and heroes».
Potentials of integrating generative artificial intelligence technologies into formative assessment processes in higher education
Authors: Paskova A. A. 
Published: July 2024

The use of generative artificial intelligence technologies in education has the potential to revolutionize learning and educational assessment by personalizing the learning experience, providing immediate feedback, and improving the overall learning experience.The relevance of the research is due to the spread of artificial intelligence technologies and the lack of practices for formative assessment of educational achievements in higher education.The problem statement: existing domestic e-learning systems have limited functionality, which makes them difficult to use in the process of formative testing.The goal of the research is to study the possibility and effectiveness of using generative artificial intelligence technologies in formative assessment in higher education.The objectives of the research are to consider the theoretical foundations of using generative artificial intelligence tools in assessing knowledge, skills and abilities, and to analyze our own experience of using large language models in formative testing at a university.The methodological basis of the research is analysis of Internet resources and literary sources, methods of mathematical statistics, and synthesis.The research results: the possibilities of using and the effectiveness of generative artificial intelligence technologies in formative testing of university students have been studied, our own experience of using large language models in formative testing have been analyzed, the main limitations of introducing these technologies into the educational process have been identified, recommendations have been given for organizing formative testing using large language models.Key conclusions: Large language models can be integrated into the learning process to assess formative and summative tests, which will significantly reduce the workload of teachers, provide more objective results and, ultimately, increase the effectiveness of the learning process.
The relationship between childhood psychological abuse and social media addiction among college students: the mediating role of fear of missing out and the moderating role of left-behind experience
Authors: Wei Peng-cheng , Yu Hai-qin 
Published: July 2024

IntroductionMobile social media is a new type of online media that is participatory, open, and communicative, among other characteristics. Due to the increasing popularity of social media, this technology has become an indispensable part of people’s social lives. This study aims to examine the relationship between childhood psychological maltreatment and social media addiction among university students as well as the mediating role of fear of missing out and the moderating effect of left-behind experience in this context.Material and methodsA voluntary anonymous online survey of 1694 university students was conducted using the Childhood Psychological Maltreatment Scale, the Fear of Missing Out Scale, and the Social Media Addiction Scale.ResultsFirst, significant positive correlations were observed between childhood psychological maltreatment and both fear of missing out and social media addiction among university students. Fear of missing out partially mediated the relationship between childhood psychological maltreatment and social media addiction. Second, left-behind experience was found to moderate the direct path from childhood psychological maltreatment to social media addiction as well as the first half of the mediating effect of missed anxiety.ConclusionsChildhood psychological maltreatment can predict social media addiction among university students not only directly but also indirectly through the mediating role of missed anxiety. The direct effect of childhood psychological maltreatment on social media addiction is moderated by left-behind experience. The first half of the mediating role of missed anxiety is also moderated by left-behind experience.
Combretastatin A4 phosphate encapsulated in hyaluronic acid nanoparticles is highly cytotoxic to oral squamous cell carcinoma
Authors: Sun Chuanxi , Zhou Ziqi , Liu Fangqiang , Li Hong , Liu Zhe 
Published: July 2024

IntroductionTo investigate the toxicity of combretastatin A4 phosphate (CA4P) hyaluronic acid (HA) gel nanoparticles (HA-CA4P-NPs) in OSCC (oral squamous cell carcinoma).MethodsToxicity was investigated using fluorescence microscopy, MTT as-say, flow cytometry, and OSCC xenograft mouse models.ResultsCompared with CA4P, HA-CA4P-NPs generated nearly 10 times more fluorescence in OSCC cells. Cytotoxicity assays showed that HACA4P-NPs were more toxic to SCC-4 cells but not to HNECs. Remarkable necrosis was induced in SCC-4 cells after exposure to HA-CA4P-NPs, and related proteins were upregulated. Furthermore, HA-CA4P-NPs significantly reduced the tu-mour size.ConclusionsHA-CA4P-NPs improved drug release and delivery, and in-creased cytotoxicity to cancer cells.
Authors: Purwaningsih Esty - , Nurelasari Ela 
Published: July 2024

Abstract: Chronic kidney disease has a significant impact on death rates from disease and continues to increase worldwide. Therefore, this research was carried out with the aim of being able to detect the disease early before it is diagnosed at a more serious stage. The application of the individual SVM method and the PSO-based SVM method was carried out to find out which model gave the best results in detecting chronic kidney disease. The SVM method has advantages in accuracy but has difficulty selecting features for the best input. So PSO Optimization (Particle Swarm Optimization) was chosen to overcome the weaknesses of SVM, because the PSO algorithm has advantages in selecting features and providing attribute weights. The results shown are that the PSO-based SVM method is successful in improving model performance and increasing the weights on attributes. From the evaluation results, the SVM kernel Dot is superior to other kernels, as proven by the SVM method alone, the accuracy was 92.25%, but after optimization using PSO, the accuracy value increased to 99.50% so there was an increase of 7.25%. Conclusion that the PSO optimization algorithm can increase the effectiveness of SVM performance, in order to predict kidney disease.

Keywords: chronic kidney, prediction, svm, optimization, pso
Pengaruh Tekhnik Rebozo Terhadap Penurunan Nyeri Punggung Pada Kehamilan Trimester III di Polindes Batu Kuta Lombok Barat
Authors: Hidayati Nurul , Munawarah Ziadatul , Utami Pramita Putri , Mubayyina Firdaus 
Published: July 2024

Ibu hamil trimester III mengalami masalah yang terjadi berulang kali. Nyeri punggung merupakan salah satu keluhan umum yang dialami oleh ibu hamil pada trimester III, yang dapat mempengaruhi kualitas hidup dan kenyamanan sehari-hari. Di Indonesia 60- 80% sakit punggung dialami diakhir trimester kehamilan. Teknik Rebozo adalah metode perawatan yang diimplementasikan sebagai pereda ketidak nyamanan umum wanita hamil. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh tekhnik rebozo terhadap penurunan nyeri punggung pada kehamilan trimester III. Penelitian ini menggunakan metode Quasi-eksperiment dengan desain penelitian one grup pretest posttest design. Sampel dalam penelitian ini adalah 30 responden. Analisis data penelitian menggunakan univariat dan bivariat Mann-Whitney.Hasil analisis univariat menunjukkan Bahwa distribusi responden sebelum dilakukan tes sesuai dengan skala nyeri sedang yang didominasi Oleh skala 4 yang terdiri Dari sejumlah 18 orang (60%),skala 5 yang terdiri Dari 8 orang(26,67%). Dan skala terendah 6 Untuk 4 Orang (13,33%).Selanjutnya Dilakukan intervensi tekhnik rebozo (post test) yang hasilnya masuk kategori “nyeri ringan”yaitu H.Pada skala 3 sebanyak 3orang (10%),Pada skala 2 sebanyak 14 orang(46,67%) dan pada skala 1 sebanyak 13 orang (43,33%). Uji Statistic Mann-Whitney menunjukkan sig(-2tailed)=0.0020 <;0,05 Sehingga dapat disimpulkan bahwa intervensi tekhnik rebozo berpengaruh sebagai penurun keluhan nyeri punggung pada ibu hamil trimester akhir.