bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Cold vs Temperate Conditions on Physical Performance During Extended Mountain Warfare Training at Moderate Altitude
Authors: Zifchock Rebecca , Silder Amy , Murphy Robert , Duong Tony , Sessoms Pinata , Jones Douglas 
Published: June 2024

ABSTRACT

Introduction
The purpose of this study was to investigate the effect of environmental conditions on body composition, upper body power, and lower body power throughout a ∼4-week military mountain training exercise. We hypothesized that countermovement jump and ballistic push-up performance would decrease as a result of extended mountain field training and that winter (cold) conditions would result in greater decrements compared to fall (temperate) conditions. We also expected to observe a strong positive correlation between changes in performance and changes in skeletal muscle mass. Finally, we expected acute changes in performance upon altitude exposure.

Materials and Methods
A total of 111 U.S. Infantry Marines (110 M; 1 F) provided written informed consent to participate in this study according to a protocol approved by the Naval Health Research Center. There were 54 participants in the fall cohort and 57 in the winter cohort. Maximum effort countermovement jump and ballistic push-up performance were assessed at different timepoints: (1) baseline at the sea level, (2) before training at ∼2100 m, (3) midpoint of training at ∼2100 m, (4) end of training at ∼2100 m, and (5) after 3 to 4 weeks of recovery at the sea level. The fall cohort trained at moderate temperatures (average day/night, 20°C/3°C), whereas the winter cohort trained under snowy winter conditions (7°C/−14°C).

Results
The results suggested that seasonal conditions did not significantly affect changes in body composition or physical performance. Furthermore, no acute effects of altitude on physical performance were detected. Training exercise did, however, cause performance decrements in countermovement jump height, countermovement jump peak power, and ballistic push-up height. Repeated measure correlation analyses suggested that there was a weak positive correlation between the decrease in skeletal muscle mass and the decrease in countermovement jump peak power throughout the training.

Conclusions
The results of our study suggest that explosive movements are negatively affected by extended military training, seemingly independent of environmental training conditions or temperature. Planning and execution of military training should account for the likelihood that warfighter physical power will decline and may not return to pretraining levels within the month following the training event. It may also be advised to consider targeted exercises to aid in recovery of muscular strength and power. Future work should consider additional factors that likely influenced the decrease in physical performance that occurs during extended military training, such as nutrition, sleep, and psychological and cognitive stresses.
A Clinical Case of Timely Diagnosis and Successful Treatment of Budd-Chiari Syndrome With Fulminant Cytolysis in the Setting of a First-time Diagnosed Myeloproliferative Disease
Authors: Husieva Svitlana A , Osyodlo Galyna V , Husiev Andrii V , Savichan Kyrylo V 
Published: June 2024

ABSTRACT
The article presents a clinical case of peculiarities of clinical manifestations, diagnostic and therapeutic approaches of undiagnosed chronic myeloproliferative disease, on the background of which Budd-Chiari syndrome (BCS) developed. The results of clinical course, examination, and treatment of a patient with BCS as a manifestation of the hidden course of primary myelofibrosis with the presence of somatic mutation (V617F) in Janus-tyrosine kinase-2 (JAK2) gene in myeloid cells are presented. Standard clinical and laboratory examinations, and cytomorphologic and histologic examination of bone marrow were used. The diagnosis of BCS was confirmed by ultrasound (US) Doppler examination of the portal system vessels. Symptomatic therapy resulted in insignificant positive results. The analysis of this clinical case showed that the development of BCS was due to a chronic myeloproliferative disease that was not diagnosed before the development of thrombosis. Hepatic vein thrombosis was accompanied by the development of fulminant cytolytic syndrome. Along with symptomatic therapy, patient K., female, 32 years old, underwent transjugular intrahepatic portosystemic shunting 1 month after the first symptoms of BCS appeared, which contributed to a significant clinical effect. Seven years after the installation of 4 transjugular intrahepatic portosystemic shunts, the patient’s condition remains satisfactory. The uniqueness of this clinical case lies in the presence of 2 serious diseases at the same time: myeloproliferative pathology (primary myelofibrosis) JAK2-positive variant and BCS. Timely diagnosis of both hematological diseases and their complication in the form of hepatic vein thrombosis with fulminant cytolytic syndrome allowed timely prescription of adequate treatment with a good clinical response.
Candida glabrata (Nakaseomyces glabrata): A systematic review of clinical and microbiological data from 2011 to 2021 to inform the World Health Organization Fungal Priority Pathogens List
Authors: Beardsley Justin , Kim Hannah Yejin , Dao Aiken , Kidd Sarah , Alastruey-Izquierdo Ana , Sorrell Tania C , Tacconelli Evelina , Chakrabarti Arunaloke , Harrison Thomas S , Bongomin Felix , Gigante Valeria , Galas Marcelo , Siswanto Siswanto , Dagne Daniel Argaw , Roitberg Felipe , Sati Hatim , Morrissey C Orla , Alffenaar Jan-Willem 
Published: June 2024

Abstract
Recognising the growing global burden of fungal infections, the World Health Organization (WHO) established an advisory group consisting of experts in fungal diseases to develop a Fungal Priority Pathogen List. Pathogens were ranked based on their research and development needs and perceived public health importance using a series of global surveys and pathogen characteristics derived from systematic reviews. This systematic review evaluates the features and global impact of invasive disease caused by Candida glabrata (Nakaseomyces glabrata). PubMed and Web of Science were searched for studies reporting on mortality, morbidity (hospitalization and disability), drug resistance (including isolates from sterile and non-sterile sites, since these reflect the same organisms causing invasive infections), preventability, yearly incidence, diagnostics, treatability, and distribution/emergence in the last 10 years. Candida glabrata (N. glabrata) causes difficult-to-treat invasive infections, particularly in patients with underlying conditions such as immunodeficiency, diabetes, or those who have received broad-spectrum antibiotics or chemotherapy. Beyond standard infection prevention and control measures, no specific preventative measures have been described. We found that infection is associated with high mortality rates and that there is a lack of data on complications and sequelae. Resistance to azoles is common and well described in echinocandins—in both cases, the resistance rates are increasing. Candida glabrata remains mostly susceptible to amphotericin and flucytosine. However, the incidence of the disease is increasing, both at the population level and as a proportion of all invasive yeast infections, and the increases appear related to the use of antifungal agents.
Candida albicans—A systematic review to inform the World Health Organization Fungal Priority Pathogens List
Authors: Parambath Sarika , Dao Aiken , Kim Hannah Yejin , Zawahir Shukry , Alastruey Izquierdo Ana , Tacconelli Evelina , Govender Nelesh , Oladele Rita , Colombo Arnaldo , Sorrell Tania , Ramon-Pardo Pilar , Fusire Terence , Gigante Valeria , Sati Hatim , Morrissey C Orla , Alffenaar Jan-Willem , Beardsley Justin 
Published: June 2024

Abstract
Candida albicans is a common fungal pathogen and amongst the leading causes of invasive candidiasis globally. This systematic review examines the characteristics and global impact of invasive infections caused by C. albicans. We searched on PubMed and Web of Science for studies reporting on criteria such as mortality, morbidity, drug resistance, preventability, yearly incidence, and distribution/emergence during the period from 2016 to 2021. Our findings indicate that C. albicans is the most common Candida species causing invasive disease and that standard infection control measures are the primary means of prevention. However, we found high rates of mortality associated with infections caused by C. albicans. Furthermore, there is a lack of data on complications and sequelae. Resistance to commonly used antifungals remains rare. Although, whilst generally susceptible to azoles, we found some evidence of increasing resistance, particularly in middle-income settings—notably, data from low-income settings were limited. Candida albicans remains susceptible to echinocandins, amphotericin B, and flucytosine. We observed evidence of a decreasing proportion of infections caused by C. albicans relative to other Candida species, although detailed epidemiological studies are needed to confirm this trend. More robust data on attributable mortality, complications, and sequelae are needed to understand the full extent of the impact of invasive C. albicans infections.
North-PHASE: studying periodicity, hot spots, accretion stability, and early evolution in young stars in the Northern hemisphere
Authors: Sicilia-Aguilar A , Kahar R S , Pelayo-Baldárrago M E , Roccatagliata V , Froebrich D , Galindo-Guil F J , Campbell-White J , Kim J S , Mendigutía I , Schlueter L , Teixeira P S , Matsumura S , Fang M , Scholz A , Ábrahám P , Frasca A , Garufi A , Herbert C , Kóspál Á , Manara C F 
Published: June 2024

ABSTRACT
We present the overview and first results from the North-PHASE Legacy Survey, which follows six young clusters for five years, using the 2 deg$^2$ FoV of the JAST80 telescope from the Javalambre Observatory (Spain). North-PHASE investigates stellar variability on time-scales from days to years for thousands of young stars distributed over entire clusters. This allows us to find new YSO, characterize accretion, and study inner disc evolution within the cluster context. Each region (Tr 37, Cep OB3, IC 5070, IC 348, NGC 2264, and NGC 1333) is observed in six filters (SDSS griz, u band, and J0660, which covers H$\alpha$), detecting cluster members as well as field variable stars. Tr 37 is used to prove feasibility and optimize the variability analysis techniques. In Tr 37, variability reveals 50 new YSO, most of them proper motion outliers. North-PHASE independently confirms the youth of astrometric members, efficiently distinguishes accreting and non-accreting stars, reveals the extent of the cluster populations along Tr37/IC 1396 bright rims, and detects variability resulting from rotation, dips, and irregular bursts. The proper motion outliers unveil a more complex star formation history than inferred from Gaia alone, and variability highlights previously hidden proper motion deviations in the surrounding clouds. We also find that non-YSO variables identified by North-PHASE cover a different variability parameter space and include long-period variables, eclipsing binaries, RR Lyr, and $\delta$ Scuti stars. These early results also emphasize the power of variability to complete the picture of star formation where it is missed by astrometry.
Hybrid approach predicts a lower binding energy for benzene on water ice
Authors: Clark Victoria H J , Benoit David M , Van de Sande Marie , Walsh Catherine 
Published: June 2024

ABSTRACT
In this paper, we provide a highly accurate value for the binding energy of benzene to proton-ordered crystalline water ice (XIh), as a model for interstellar ices. We compare our computed value to the latest experimental data available from temperature-programmed desorption experiments and find that our binding energy value agrees well with data obtained from binding to either crystalline or amorphous ice. Importantly, our new value is lower than that used in most astrochemical networks by about nearly half its value. We explore the impact of this revised binding energy value for both an asymptotic giant branch (AGB) outflow and a protoplanetary disc. We find that the lower value of the binding energy predicted here compared with values used in the literature (4050 K versus 7587 K) leads to less depletion of gas-phase benzene in an AGB outflow, and leads to a shift outwards in the benzene snowline in the mid-plane of a protoplanetary disc. Using this new value, the AGB model predicts lower abundances of benzene in the solid phase throughout the outflow. The disc model also predicts a larger reservoir of gas-phase benzene in the inner disc, which is consistent with the recent detections of benzene for the first time in protoplanetary discs with JWST.
An ATP-responsive metal–organic framework against periodontitis via synergistic ion-interference-mediated pyroptosis
Authors: Yang Qijing , Sun Xiaolin , Ding Qihang , Qi Manlin , Liu Chengyu , Li Tingxuan , Shi Fangyu , Wang Lin , Li Chunyan , Kim Jong Seung 
Published: June 2024

ABSTRACT
Periodontitis involves hyperactivated stromal cells that recruit immune cells, exacerbating inflammation. This study presents an ATP-responsive metal–organic framework (Mg/Zn-MOF) designed for periodontitis treatment, utilizing ion interference to modulate immune responses and prevent tissue destruction. Addressing the challenges of synergistic ion effects and targeted delivery faced by traditional immunomodulatory nanomaterials, the Mg/Zn-MOF system is activated by extracellular ATP—a pivotal molecule in periodontitis pathology—ensuring targeted ion release. Magnesium and zinc ions released from the framework synergistically inhibit membrane pore formation by attenuating Gasdermin D (GSDMD) expression and activation. This action curtails pyroptosis, lactate dehydrogenase and IL-1β release, thwarting the onset of inflammatory cascades. Mechanistically, Mg/Zn-MOF intervenes in both the NLRP3/Caspase-1/GSDMD and Caspase-11/GSDMD pathways to mitigate pyroptosis. In vivo assessments confirm its effectiveness in diminishing inflammatory cell infiltration and preserving collagen integrity, thereby safeguarding against periodontal tissue damage and bone loss. This investigation highlights the promise of ion-interference strategies in periodontitis immunotherapy, representing a significant stride in developing targeted therapeutic approaches.
A Tale of Two Ṭarīqas: The Iraqi and Khurasani Shāfiʿī Communities in the Fourth/Tenth and Fifth/Eleventh Centuries
Authors: Sheibani Mariam 
Published: June 2024

Abstract
This article provides a new account of Shāfiʿī legal history in the fourth/tenth and fifth/eleventh centuries: a tale of two ṭarīqas, or interpretive communities, one in Iraq and the other in Khurasan. I show that these two Shāfiʿī communities developed as distinct social and scholarly collectives before gradually converging in Ayyubid Damascus and eventually coalescing around one authoritative school doctrine in the Mamluk period. I reconstruct the networks of Shāfiʿī jurists in the two regions and show how and why the two groups differed in their legal reasoning and their paradigm of the madhhab (legal school). Although all of these jurists shared a transregional affiliation with the Shāfiʿī madhhab that distinguished them from jurists belonging to other legal schools, I argue that these affinities were countered by geographical boundaries and diverging local developments that led to the differentiation of the Iraqi and Khurasani Shāfiʿī communities. These insights not only complicate our understanding of what constitutes the post-formative madhhab as an institution but also demonstrate how broader intellectual and institutional developments, such as the ascendancy of Ashʿarism, the emergence of new centres of scholarship, and the introduction of the madrasa, shaped the internal workings of the madhhab.
The embodiment of the neighborhood socioeconomic environment in the architecture of the immune system
Authors: Noppert Grace A , Clarke Philippa , Stebbins Rebecca C , Duchowny Kate A , Melendez Robert , Rollings Kimberly , Aiello Allison E 
Published: June 2024

Abstract
There is growing recognition of the importance of immune health for understanding the origins of ageing-related disease and decline. Numerous studies have demonstrated consistent associations between the social determinants of health and immunosenescence (i.e. ageing of the immune system). Yet few studies have interrogated the relationship between neighborhood socioeconomic status (nSES) and biologically specific measures of immunosenescence. We used data from the US Health and Retirement Study to measure immunosenescence linked with neighborhood socioeconomic data from the National Neighborhood Data Archive to examine associations between indicators of nSES and immunosenescence. We found associations between both the ratio of terminally differentiated effector memory to naïve (EMRA:Naïve) CD4+ T cells and cytomegalovirus (CMV) immunoglobulin G (IgG) levels and nSES. For the CD4+ EMRA:Naïve ratio, each 1% increase in the neighborhood disadvantage index was associated with a 0.005 standard deviation higher value of the EMRA:Naïve ratio (95% CI: 0.0003, 0.01) indicating that living in a neighborhood that is 10% higher in disadvantage is associated with a 0.05 higher standardized value of the CD4+ EMRA:Naïve ratio. The results were fully attenuated when adjusting for both individual-level SES and race/ethnicity. For CMV IgG antibodies, a 1% increase in neighborhood disadvantage was associated a 0.03 standard deviation higher value of CMV IgG antibodies (β = 0.03; 95% CI: 0.002, 0.03) indicating that living in a neighborhood that is 10% higher in disadvantage is associated with a 0.3 higher standardized value of CMV. This association was attenuated though still statistically significant when controlling for individual-level SES and race/ethnicity. The findings from this study provide compelling initial evidence that large, nonspecific social exposures, such as neighborhood socioeconomic conditions, can become embodied in cellular processes of immune ageing.
Perceived legitimacy of agricultural support schemes: An investigation using factorial survey experiments
Authors: Glenk Klaus , Liebe Ulf , Burns Jay , Thomson Steven 
Published: June 2024

Abstract
Agricultural support payments are a significant position in public budgets, and the legitimacy of such payments is subject to continuing debate. The legitimacy rests on the social acceptance of citizens for support payments to farmers, which is the focus of this study. Social acceptance is investigated using evaluations of farm and farmer descriptions in a factorial survey experiment. The results reveal higher acceptance of payments for farms demonstrating enhanced animal welfare, biodiversity, and a lower carbon footprint. The acceptance of support payments is negatively associated with payment amount, but payments to farmers who are financially struggling are more accepted than payments to profitable farmers; indicating respondent preferences that align with the need justice principle. Study findings can be used to inform priorities for legitimate policies of agricultural support schemes, to identify areas of consensus or disagreement regarding social acceptance of support, and to facilitate effective communication on agricultural support policy.
Imagining the Future: Memory, Simulation, and Beliefs
Authors: Bordalo Pedro , Burro Giovanni , Coffman Katherine , Gennaioli Nicola , Shleifer Andrei 
Published: June 2024

Abstract
How do people form beliefs about novel risks, with which they have little or no experience? Motivated by survey data on beliefs about COVID we collected in 2020, we build a model based on the psychology of selective memory. When a person thinks about an event, different experiences compete for retrieval, and retrieved experiences are used to simulate the event based on how similar they are to it. The model predicts that different experiences interfere with each other in recall and that non-domain-specific experiences can bias beliefs based on their similarity to the assessed event. We test these predictions using data from our COVID survey and from a primed-recall experiment about cyberattack risk. In line with our theory of similarity-based retrieval and simulation, experiences and their measured similarity to the cued event help account for experience effects, priming effects, and the interaction of the two in shaping beliefs.
Stochastic Character Mapping, Bayesian Model Selection, and Biosynthetic Pathways Shed New Light on the Evolution of Habitat Preference in Cyanobacteria
Authors: Bianchini Giorgio , Hagemann Martin , Sánchez-Baracaldo Patricia 
Published: June 2024

Abstract
Cyanobacteria are the only prokaryotes to have evolved oxygenic photosynthesis paving the way for complex life. Studying the evolution and ecological niche of cyanobacteria and their ancestors is crucial for understanding the intricate dynamics of biosphere evolution. These organisms frequently deal with environmental stressors such as salinity and drought, and they employ compatible solutes as a mechanism to cope with these challenges. Compatible solutes are small molecules that help maintain cellular osmotic balance in high-salinity environments, such as marine waters. Their production plays a crucial role in salt tolerance, which, in turn, influences habitat preference. Among the 5 known compatible solutes produced by cyanobacteria (sucrose, trehalose, glucosylglycerol, glucosylglycerate, and glycine betaine), their synthesis varies between individual strains. In this study, we work in a Bayesian stochastic mapping framework, integrating multiple sources of information about compatible solute biosynthesis in order to predict the ancestral habitat preference of Cyanobacteria. Through extensive model selection analyses and statistical tests for correlation, we identify glucosylglycerol and glucosylglycerate as the most significantly correlated with habitat preference, while trehalose exhibits the weakest correlation. Additionally, glucosylglycerol, glucosylglycerate, and glycine betaine show high loss/gain rate ratios, indicating their potential role in adaptability, while sucrose and trehalose are less likely to be lost due to their additional cellular functions. Contrary to previous findings, our analyses predict that the last common ancestor of Cyanobacteria (living at around 3180 Ma) had a 97% probability of a high salinity habitat preference and was likely able to synthesize glucosylglycerol and glucosylglycerate. Nevertheless, cyanobacteria likely colonized low-salinity environments shortly after their origin, with an 89% probability of the first cyanobacterium with low-salinity habitat preference arising prior to the Great Oxygenation Event (2460 Ma). Stochastic mapping analyses provide evidence of cyanobacteria inhabiting early marine habitats, aiding in the interpretation of the geological record. Our age estimate of ~2590 Ma for the divergence of 2 major cyanobacterial clades (Macro- and Microcyanobacteria) suggests that these were likely significant contributors to primary productivity in marine habitats in the lead-up to the Great Oxygenation Event, and thus played a pivotal role in triggering the sudden increase in atmospheric oxygen.