bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heterogeneity in Asthma Care in a Statewide Collaborative: the Ohio Pediatric Asthma Repository
Authors: Biagini Myers Jocelyn M. , Simmons Jeffrey M. , Kercsmar Carolyn M. , Martin Lisa J. , Pilipenko Valentina V. , Austin Stephen R. , Lindsey Mark A. , Amalfitano Katharine M. , Guilbert Theresa W. , McCoy Karen S. , Forbis Shalini G. , McBride John T. , Ross Kristie R. , Vauthy Pierre A. , Khurana Hershey Gurjit K. 
Published: January 2015

BACKGROUND AND OBJECTIVE:
Asthma heterogeneity causes difficulty in studying and treating the disease. We built a comprehensive statewide repository linking questionnaire and medical record data with health outcomes to characterize the variability of clinical practices at Ohio children’s hospitals for the treatment of hospitalized asthma.

METHODS:
Children hospitalized at 6 participating Ohio children’s hospitals for asthma exacerbation or reactive airway disease aged 2 to 17 were eligible. Medical, social, and environmental histories and past asthma admissions were collected from questionnaires and the medical record.

RESULTS:
From December 2012 to September 2013, 1012 children were enrolled. There were significant differences in the population served, emergency department and inpatient practices, intensive care unit usage, discharge criteria, and length of stay across the sites (all P &lt; .0001, total n = 1012). Public insurance was highest in Cleveland and Cincinnati (72 and 65%). In the emergency department, Cincinnati and Akron had the highest intravenous magnesium sulfate use (37% and 33%); Columbus administered the most intramuscular epinephrine (15%). Cleveland and Columbus had the highest intensive care unit admittance (44% and 41%) and proportion of long-stay patients (95% and 85%). Moderate/severe asthma severity classification was associated with discharge prescription for inhaled corticosteroids (odds ratio = 2.7; 95% confidence interval: 1.6–4.5; P = .004) but not stay length.

CONCLUSIONS:
These data highlight the need for standardization of treatment practices for inpatient asthma care. There is considerable opportunity for personalized care plans that incorporate a patient’s asthma impairment, risk, and treatment response history into hospital practices for asthma exacerbation treatment. The Ohio Pediatric Asthma Repository is a unique statewide resource in which to conduct observational, comparative effectiveness, and ultimately intervention studies for pediatric asthma.
A „Pasteiner-tanszék” vége az 1917–1918-as tanszéki pályázat története és iratai
Authors: Gosztonyi Ferenc 
Published: January 2015

Gyula Pasteiner (1846–1924), professor of art history at Budapest University retired in 1916. The minister of religion and public education issued an advertisement of the vacancy calling for applications (deadline: 15 August 1917). Six persons replied to the call until the deadline: László Éber, Tibor Gerevich, Antal Hekler, Béla Lázár, Simon Meller and Zoltán Felvinczi Takács. In the paper I present the history of the vacancy on the basis of documents preserved at the Archive of Eötvös Loránd University. The university committee in charge of the appointment of the new professor asked Pasteiner to make a preliminary evaluation of the applications. In his lengthy review presented on 10 May 1918 (Appendix I “Pasteiner’s report on the applications”) he did not find any of the applicants fit for the chair. Pasteiner’s negative view was rooted partly in the antagonism between university and museum practice also deepened by him. All the applicants were namely specialists in museology or historic monument protection. As Pasteiner put it, “The Germans have long realized the difference between the two disciplines and translated this recognition into practice. Not even in exceptional cases do practitioners of museum science lay claim to a department chair, and conversely, a university department lecturer would not give up his job for museum activity.”
The committee of the faculty of humanities did not accept Pasteiner’s opinion, and supported the classical archeologist Antal Hekler’s or Hekler’s and art historian and curator of the Museum of Fine Arts Simon Meller’s candidacy “aequo loco”. When the post was announced, Hekler, a one-time pupil of Adolf Furtwängler was privatdocent of archeology at Budapest University, curator of the Museum of Fine Arts and director of the Hungarian Scientific Institute in Constantinople among other engagements. Meller’s best-known publication was the study Die Reiterdarstellungen Leonardos und die Budapester Bronzestatuette (Jahrbuch der Königlich Preussischen Kunstsammlungen, 1916). In support of Meller some European colleagues also put pen to paper, such as Wilhelm von Bode, Adolf Goldschmidt and Max Dvořak. Eventually Hekler was appointed to the post, presumably upon political pressure. Pasteiner submitted a protest to the minister (Appendix II: “Pasteiner’s dissenting opinion”). Meller’s supporters also protested, without success.
The legendary dual institutional structure of art historical education at Budapest University began with the appointment of Hekler in October 1918. The second professor, his rival Tibor Gerevich, was not appointed before 1924.
II. Ferdinánd Habsburg főherceg (1529–1595) portréja az esztergomi Keresztény Múzeumban
Authors: Katona Ágnes 
Published: January 2015

I would like to prove that the picture in the stock of the Esztergom Christian Museum attributed as North Italian painter, end of 16th century, Noble Man in Armor was painted by the unknown Bergamo follower of Francesco Terzi (Bergamo, 1523 – Roma 1591) around 1569.
I certify the attribution and its dating by comparing it with the works of Terzi. Francesco Terzi court painter and graphical artist worked mainly in Austria. The main point of the painting is that – according to my researches – it portrays Ferdinand II, the Habsburg Archduke, famous collector, who himself ordered many works of Terzi. I bring up analogies to this attribution representing Ferdinand II. I describe the opinions of researchers in the question of attributing and dating these works and also take a position in it.
Diferenciales de productividad empresarial según su posición internacional. El caso del sector químico Español
Authors: Pol Miró Albert 
Published: January 2015

En este trabajo se estudia la relación entre la productividad y la posición internacional que ocupan las empresasespañolas y portuguesas del sector químico en el año 2011, con el objetivo de contribuir a la literatura económicaal determinar si las empresas que se internacionalizan, ya sea mediante exportación o inversión, son más productivas que aquellas que no venden en el mercado mundial. En primer lugar se elabora una muestra de corte transversal para posteriormente realizar la estimación de la función de producción. Por último, se concluye que en la muestra utilizada la actividad exportadora es la que tiene un mayor peso en el crecimiento de la productividad.
Gerencia de proyectos en el contexto del periodismo ambiental
Authors: Patiño Flórez Rosa Isabel 
Published: January 2015

El artículo presenta los retos que tiene el periodismo ambiental como dinamizador de los procesos de transformación social, de cambio en las representaciones sociales de la población y en el análisis de los efectos e impactos de la actividad humana sobre el ambiente y el bienestar de la comunidad desde la perspectiva de la ciencia y la tecnologia. A su vez, plantea elementos de reﬂexión sobre el desarrollo de la competencia investigativa en los periodistas, que les permita desarrollar su papel en función de generar capacidades en las personas para la autogestión, la participación y las deciciones sobre la sostenibilidad del planeta. Introduce conceptos relacionados la con gerencia de proyectos y pondera el talento humano, la clave del éxito. Describe cada una de las fases del ciclo de vida del proyecto y en las conclusiones presentala experiencia del convenio ﬁrmado entre la Corporación Autónoma Regional de los Valles del Sinú y del San Jorge - CVS y la Red Colombiana de Formación Ambiental - RCFA, con el propósito de fortalecer la cultura ambiental ciudadana en las comunidadesdel Departamento de Córdoba, a través del convenio. Cualifìcación del Recurso Humano para el Fortalecimiento de los Procesos de Educación no Formal, mediante la puesta en marcha de dos componentes: 1. Obtención de alianzas o acuerdos orientados al mejoramiento y a la sostenibilidad de los espacios públicos en tres áreas estratégicas de Montería; 2. Realización de un diplomado en periodismo ambiental dirigido a comunicadores sociales del departamento de Córdoba.
La crisis del medio ambiente
Authors: Quintero Vélez Juan Carlos , Camacho Delgado Clemencia 
Published: January 2015

Este artículo, introducción al tema del medio ambiente, pretende proporcionar conceptos básicos para analizar y dimensionar el impacto que genera el hombre sobre los sistemas que soportan la vida. Para entender estos problemas, es indispensable partir de un análisis básico de la relación entre el hombre actual, su medio ambiente, sus necesidades y sus actividades. El autor revisa los antecedentes, las causas y las consecuencias de la crisis ambiental internacional, e intenta dar explicación a la problemática nacionalen este campo, y establecer los puntos más críticos en Colombia. Finalmente, con base en los parámetros establecidos por el gobierno, se presenta el concepto de“desarrollo sostenible" como modelo que interrelaciona los procesos económicos, sociales y tecnológicos con el medio ambiente.
Diseño de un sistema de costos para pymes
Authors: Pineda Marín Edilma 
Published: January 2015

La pequeña empresa colombiana, con limitaciones en recursos financieros, tecnológicos y humanos requiere de apoyo administrativo y contable que faciliten gestionar sus propios procesos de crecimiento. Las ofertas de valor que las empresas proponen a los consumidores requieren ser costeadas de manera tal que el valor percibido por estos, permita a las organizaciones la fijación de precios y la toma de decisio- nes en los diferentes ámbitos ya sea financiero, de mercadeo o de producción, entre otros.
Standard Versus Continuous Administration of Capecitabine in Metastatic Breast Cancer (GEICAM/2009-05): A Randomized, Noninferiority Phase II Trial With a Pharmacogenetic Analysis
Authors: Martín Miguel , Martínez Noelia , Ramos Manuel , Calvo Lourdes , Lluch Ana , Zamora Pilar , Muñoz Montserrat , Carrasco Eva , Caballero Rosalía , García-Sáenz José Ángel , Guerra Eva , Caronia Daniela , Casado Antonio , Ruíz-Borrego Manuel , Hernando Blanca , Chacón José Ignacio , De la Torre-Montero Julio César , Jimeno María Ángeles , Heras Lucía , Alonso Rosario , De la Haba Juan , Pita Guillermo , Constenla Manuel , González-Neira Anna 
Published: January 2015

Abstract

Author Summary

Background.
The approved capecitabine regimen as monotherapy in metastatic breast cancer (MBC) is 1,250 mg/m2 twice daily for 2 weeks on and 1 week off (Cint). Dose modifications are often required because of severe hand-foot syndrome (HFS). We tested a continuous regimen with a lower daily dose but a similar cumulative dose in an attempt to reduce the severity of adverse events (AEs) while maintaining efficacy.

Methods.
We randomized 195 patients with HER-2/neu-negative MBC to capecitabine 800 mg/m2 twice daily throughout the 21-day cycle (Ccont) or to Cint to assess noninferiority in the percentage of patients free of progression at 1 year. Secondary endpoints included efficacy and safety. Associations between polymorphisms in capecitabine metabolism-related genes and drug response were assessed.

Results.
The percentage of patients free of progression at 1 year was 27.3% with Cint versus 25.3% with Ccont (difference of −2.0%; 95% confidence interval: −15.5% to 11.5%, exceeding the 15% deemed noninferior). Differences regarding other efficacy variables were also not found. Grade 3–4 HFS was the most frequent AE (41.1% in Cint vs. 42.3% in Ccont). Grade 3–4 neutropenia, thrombocytopenia, diarrhea, and stomatitis were more frequent with Cint. A 5′ untranslated region polymorphism in the carboxylesterase 2 gene was associated with HFS. One polymorphism in cytidine deaminase and two in thymidine phosphorylase were associated with survival.

Conclusion.
Our study was unable to show noninferiority with the continuous capecitabine regimen (Ccont) compared with the approved intermittent regimen (Cint). Further investigation is required to improve HFS. Polymorphisms in several genes might contribute to interindividual differences in response to capecitabine.
Is There a Role for Oral or Intravenous Ascorbate (Vitamin C) in Treating Patients With Cancer? A Systematic Review
Authors: Jacobs Carmel , Hutton Brian , Ng Terry , Shorr Risa , Clemons Mark 
Published: January 2015

Abstract

Background.
Many cancer patients receive supplemental ascorbate (vitamin C) in the belief that it synergizes the anticancer effects of chemotherapy and reduces its toxicity.

Methods.
A systematic review was performed to evaluate the antitumor effects and toxicity of ascorbate treatment. Medline (1946 to March 2014), EMBASE (1947 to March 2014), and the Cochrane central register (1993 to March 2014) were searched for randomized and observational studies.

Results.
Of 696 identified records, 61 full-text articles were screened and 34 were included. In total, 5 randomized controlled trials (RCTs) (n = 322), 12 phase I/II trials (n = 287), 6 observational studies (n = 7,599), and 11 case reports (n = 267) were identified. Because of study heterogeneity, no meta-analyses were performed. No RCTs reported any statistically significant improvements in overall or progression-free survival or reduced toxicity with ascorbate relative to control arm. Evidence for ascorbate's antitumor effects was limited to case reports and observational and uncontrolled studies.

Conclusion.
There is no high-quality evidence to suggest that ascorbate supplementation in cancer patients either enhances the antitumor effects of chemotherapy or reduces its toxicity. Given the high financial and time costs to patients of this treatment, high-quality placebo-controlled trials are needed.
Translating a Fall Prevention Intervention Into Practice: A Randomized Community Trial
Authors: Guse Clare E. , Peterson Donna J. , Christiansen Ann L. , Mahoney Jane , Laud Purushottam , Layde Peter M. 
Published: January 2015

Objectives. We examined whether community translation of an effective evidence-based fall prevention program via standard monetary support can produce a community-wide reduction in fall injuries in older adults and evaluated whether an enhanced version with added technical support and capacity building amplified the fall reduction effect. Methods. We completed a randomized controlled community trial among adults aged 65 and older in (1) 10 control communities receiving no special resources or guidance on fall prevention, (2) 5 standard support communities receiving modest funding to implement Stepping On, and (3) 5 enhanced support communities receiving funding and technical support. The primary outcome was hospital inpatient and emergency department discharges for falls, examined with Poisson regression. Results. Compared with control communities, standard and enhanced support communities showed significantly higher community-wide reductions (9% and 8%, respectively) in fall injuries from baseline (2007–2008) to follow-up (2010–2011). No significant difference was found between enhanced and standard support communities. Conclusions. Population-based fall prevention interventions can be effective when implemented in community settings. More research is needed to identify the barriers and facilitators that influence the successful adoption and implementation of fall prevention interventions into broad community practice.
Too Little, Too Late: Ineffective Regulation of Dietary Supplements in the United States
Authors: Starr Ranjani R. 
Published: January 2015

Millions of people in the United States consume dietary supplements hoping to maintain or improve their health; however, extensive research has failed to demonstrate the efficacy of numerous supplements in disease prevention. In addition, concerns about the safety of routine and high-dose supplementation have been raised. The Food and Drug Administration regulates dietary supplement quality, safety, and labeling, and the Federal Trade Commission monitors advertisements and marketing; still, vast enforcement challenges remain, and optimal governmental oversight has not been achieved. If the composition and quality of ingredients cannot be reliably ensured, the validity of research on dietary supplements is questionable. Moreover, the health of the US public is put at risk.
A Comprehensive Approach to Address the Prescription Opioid Epidemic in Washington State: Milestones and Lessons Learned
Authors: Franklin Gary , Sabel Jennifer , Jones Christopher M. , Mai Jaymie , Baumgartner Chris , Banta-Green Caleb J. , Neven Darin , Tauben David J. 
Published: January 2015

An epidemic of morbidity and mortality has swept across the United States related to the use of prescription opioids for chronic noncancer pain. More than 100 000 people have died from unintentional overdose, making this one of the worst manmade epidemics in history. Much of health care delivery in the United States is regulated at the state level; therefore, both the cause and much of the cure for the opioid epidemic will come from state action. We detail the strong collaborations across executive health care agencies, and between those public agencies and practicing leaders in the pain field that have led to a substantial reversal of the epidemic in Washington State.
Self-Help for Weight Loss in Overweight and Obese Adults: Systematic Review and Meta-Analysis
Authors: Hartmann-Boyce Jamie , Jebb Susan A. , Fletcher Ben R. , Aveyard Paul 
Published: January 2015

We conducted a systematic review and meta-analysis investigating the components and effectiveness of self-help weight-loss interventions and their applicability to less-advantaged populations. We searched (November 2013) for randomized controlled trials comparing self-help interventions with each other or with minimal controls in overweight and obese adults, with 6 months or longer follow-up. We calculated mean difference between intervention and control for 6- and 12-month weight change. Twenty-three studies met the inclusion criteria (9632 participants; 39 intervention arms). Intervention participants lost significantly more weight than controls at 6 months (mean difference −1.85 kg; 95% confidence interval [CI] = −2.86, −0.83; 7 studies). No significant effect was detected at 12 months but results were sensitive to the inclusion of 1 study at high risk of bias. Interactive programs appeared more effective than standard ones at 6 months (mean difference −0.94 kg; 95% CI = −1.50, −0.38). Evidence is insufficient to reach conclusions on effectiveness in socioeconomically disadvantaged people, but suggests self-help interventions may be less effective in this group.
Primary failure rate for 1680 extra-alveolar mandibular buccal shelf mini-screws placed in movable mucosa or attached gingiva
Authors: Chang Chris , Liu Sean S.Y. , Roberts W. Eugene 
Published: January 2015

ABSTRACT

Objective:
To compare the initial failure rate (≤4 months) for extra-alveolar mandibular buccal shelf (MBS) miniscrews placed in movable mucosa (MM) or attached gingiva (AG).

Materials and Methods:
A total of 1680 consecutive stainless steel (SS) 2 × 12-mm MBS miniscrews were placed in 840 patients (405 males and 435 females; mean age, 16 ± 5 years). All screws were placed lateral to the alveolar process and buccal to the lower first and second molar roots. The screw heads were at least 5 mm superior to the soft tissue. Loads from 8 oz–14 oz (227 g–397 g, 231–405 cN) were used to retract the mandibular buccal segments for at least 4 months.

Results:
Overall, 121 miniscrews out of 1680 (7.2%) failed: 7.31% were in MM and 6.85% were in AG (statistically insignificant difference). Failures were unilateral in 89 patients and bilateral in 16. Left side (9.29%) failures was significantly greater (P &lt; .001) compared with those on the right (5.12%). Average age for failure patients was 14 ± 3 years.

Conclusion:
MBS miniscrews were highly successful (approximately 93%), but there was no significant difference between placement in MM or AG. Failures were more common on the patient's left side and in younger adolescent patients. Having 16 patients with bilateral failures suggests that a small fraction of patients (1.9%) are predisposed to failure with this method.
Pharmacokinetics, Safety and Efficacy of Ritonavir-Boosted Atazanavir (300/100 mg Once Daily) in HIV-1-Infected Pregnant Women
Authors: Lê Minh P , Mandelbrot Laurent , Descamps Diane , Soulié Cathia , Ichou Houria , Bourgeois-Moine Agnès , Damond Florence , Lariven Sylvie , Valantin Marc-Antoine , Landman Roland , Faucher Philippe , Tubiana Roland , Duro Dominique , Meier Françoise , Legac Sylvie , Bourse Patricia , Mortier Emmanuel , Dommergues Marc , Calvez Vincent , Matheron Sophie , Peytavin Gilles 
Published: January 2015

Background Atazanavir/ritonavir (ATV/r) is a boosted protease inhibitor recommended to minimize the risk of mother-to-child HIV-1 transmission (MTCT). We aimed to assess the pharmacokinetics, safety and efficacy of ATV/r in HIV-1-infected pregnant women and their neonates. Methods A multicentre, cross-sectional, non-interventional cohort of HIV-1-infected pregnant women receiving ATV/r (300/100 mg once daily) who delivered in three Paris hospitals from 2006 to 2013 was designed. We determined antiretroviral trough plasma concentrations using liquid chromatography–mass spectrometry at each of the three trimesters, delivery and post-partum. ATV concentrations at 24 h (C24h) were interpreted by the 150–850 ng/ml efficacy–tolerance thresholds. Safety data and newborn HIV status were recorded. A mother's virological failure was defined as two successive measurements of plasma HIV-1 RNA>50 copies/ml within the 2 months before delivery. Results 103 pregnant women were included, mostly from sub-Saharan Africa (88%). ATV C24h at each of the three trimesters and delivery remained similar to post-partum values. No dose adjustment was needed during pregnancy. The median plasma ratio of fetal/ maternal ATV level was 0.19 ( n=28). Only three patients showed two successive detectable viral loads but <400 copies/ml. Among 82 available newborn data, 16 were born preterm. Three in utero deaths occurred. Tolerance was good with one case of maternal grade 3 hyperbilirubinaemia, no cases in neonates at delivery and no clinically relevant adverse event. No case of MTCT was reported. Conclusions In this population, an ATV/r-containing anti-retroviral regimen demonstrated good pharmacokinetics, virological efficacy and safety. No significant impact of pregnancy on ATV C24h was found. No dose adjustment was required.
Ce que ça cache
Authors: Laurens Camille 
Published: January 2015

Avec la traversée de chacune de ses publications, Camille Laurens évoque les étapes de son parcours d’écrivain impliqué dans un travail personnel avec la psychanalyse, en tentant de décrire « comment l’exercice de la littérature est totalement imbriqué pour [elle] avec la pratique de la psychanalyse – pratique comme analysante, pratique comme lectrice de textes de psychanalyse ».
René Char – Maurice Blanchot : la métaphore et le fragment...
Authors: Henri-Ménassé Catherine 
Published: January 2015

À partir des œuvres fragmentaires de René Char et de Maurice Blanchot, se pose la question de la dynamique du rapport entre le fragment et la métaphore. Si le fragment est une modalité d’écriture rompant la linéarité de la pensée et a pour effet de mettre le lecteur au cœur de l’œuvre, il est aussi un facteur d’immobilisation du flux idéique. Le système métaphorique joue-t-il alors comme une ligne mélodique soutenant, sur un mode hallucinatoire, l’émergence de la pensée propre du lecteur ?