bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delineating the Role of Multiple Intraarticular Corticosteroid Injections in the Management of Juvenile Idiopathic Arthritis in the Biologic Era
Authors: Papadopoulou Charalampia , Kostik Mikhail , Gonzalez‐Fernandez Maria Isabel , Bohm Marek , Nieto‐Gonzalez Juan Carlos , Pistorio Angela , Lanni Stefano , Consolaro Alessandro , Martini Alberto , Ravelli Angelo 
Published: January 2013

ObjectiveTo investigate the outcome and predicting factors of multiple intraarticular corticosteroid (IAC) injections in children with juvenile idiopathic arthritis (JIA).MethodsThe clinical charts of patients who received their first IAC injection in ≥3 joints between January 2002 and December 2011 were reviewed. The corticosteroid used was triamcinolone hexacetonide for large joints and methylprednisolone acetate for small or difficult to access joints. In each patient, the followup period after IAC injection was censored in case of synovitis flare or at the last visit with continued remission. Predictors included sex, age at disease onset, JIA category, antinuclear antibody (ANA) status, age and disease duration, disease course, general anesthesia, number and type of injected joints, acute‐phase reactants, and concomitant systemic medications.ResultsA total of 220 patients who had 1,096 joints injected were included. Following IAC therapy, 66.4% of patients had synovitis flare after a median of 0.5 years, whereas 33.6% of patients had sustained remission after a median of 0.9 years. The cumulative probability of survival without synovitis flare was 50.0%, 31.5%, and 19.5% at 1, 2, and 3 years, respectively. On Cox regression analysis, positive C‐reactive protein value, negative ANA, lack of concomitant methotrexate administration, and a polyarticular (versus an oligoarticular) disease course were the strongest predictors for synovitis flare.ConclusionMultiple IAC injection therapy induced sustained remission of joint synovitis in a substantial proportion of patients. A controlled trial comparing multiple IAC injection therapy and methotrexate versus methotrexate and a tumor necrosis factor antagonist is worthy of consideration.
Systematic Review of Validation Studies of the Use of Administrative Data to Identify Serious Infections
Authors: Barber Claire , Lacaille Diane , Fortin Paul R. 
Published: January 2013

ObjectiveTo conduct a systematic review of the literature on the validation of algorithms identifying infections in administrative data for future use in populations with rheumatic diseases.MethodsMedline and EMBase were searched using the themes “administrative data” and “infection” between 1950 and October 2012. Inclusion criteria consisted of validation studies of administrative data identifying infections in adult populations. Article quality was assessed using a validated tool.ResultsA total of 5,941 articles were identified, 90 articles underwent detailed review, and 24 studies were included. The majority (17 of 24) examined bacterial infections and 9 examined opportunistic infections. Eighteen studies were from the US and all but 4 studies used International Classification of Diseases, Ninth Revision codes. Rheumatoid arthritis patients were studied in 6 of 24 articles. The studies on bacterial infections in general reported highly variable sensitivity and positive predictive value (PPV) for the diagnosis of infections using administrative data (sensitivity range 4.4–100%, PPV range 21.7–100%). Algorithms to identify opportunistic infections similarly had a highly variable sensitivity (range 20–100%) and PPV (range 1.3–100%). Thirteen studies compared the diagnostic accuracy of different algorithms, which revealed that strategies including a comprehensive algorithm using a greater number of diagnostic codes or codes in any position had the highest sensitivity for the diagnosis of infection. Algorithms that incorporated microbiologic or pharmacy data in combination with diagnostic codes had improved PPV for identification of tuberculosis.ConclusionAlgorithms for identifying infections using administrative data should be selected based on the purpose of the study, with careful consideration as to whether a high sensitivity or PPV is required.
Functional Free‐Standing Graphene Honeycomb Films
Authors: Yin Shengyan , Goldovsky Yulia , Herzberg Moshe , Liu Lei , Sun Hang , Zhang Yanyan , Meng Fanben , Cao Xuebo , Sun Darren D. , Chen Hongyu , Kushmaro Ariel , Chen Xiaodong 
Published: January 2013

AbstractFabricating free‐standing, three‐dimensional (3D) ordered porous graphene structure can service a wide range of functional materials such as environmentally friendly materials for antibacterial medical applications and efficient solar harvesting devices. A scalable solution processable strategy is developed to create such free‐standing hierarchical porous structures composed of functionalized graphene sheets via an “on water spreading” method. The free‐standing film shows a large area uniform honeycomb structure and can be transferred onto any substrate of interest. The graphene‐based free‐standing honeycomb films exhibit superior broad spectrum antibacterial activity as confirmed using green fluorescent protein labeled Pseudomonas aeruginosa PAO1 and Escherichia coli as model pathogens. Functional nanoparticles such as titanium dioxide (TiO2) nanoparticles can be easily introduced into conductive graphene‐based scaffolds by premixing. The formed composite honeycomb film electrode shows a fast, stable, and completely reversible photocurrent response accompanying each switch‐on and switch‐off event. The graphene‐based honeycomb scaffold enhances the light‐harvesting efficiency and improves the photoelectric conversion behavior; the photocurrent of the composite film is about two times as high as that of the pure TiO2 film electrode. Such composite porous films combining remarkably good electrochemical performance of graphene, a large electrode/electrolyte contact area, and excellent stability during the photo‐conversion process hold promise for further applications in water treatment and solar energy conversion.
Effect of Solute‐ and Solvent‐Derived Marangoni Flows on the Shape of Polymer Films Formed from Drying Droplets
Authors: Babatunde Patience Oluwatosin , Hong Wang Jing , Nakaso Koichi , Fukai Jun 
Published: January 2013

SignificanceThe effects of mixed solvents on the shape of films formed on a hydrophilic surface from polymer solute droplets were investigated experimentally. The film shape depended on the two solvents used, and the mixing ratio. It was also found that the flow direction was dominated by solute‐derived rather than solvent‐derived Marangoni flows. Consequently, the changes in the shape of the film could not be explained only by the Marangoni flow direction.
Exploring Occupational and Health Behavioral Causes of Firefighter Obesity: A Qualitative Study
Authors: Dobson Marnie , Choi BongKyoo , Schnall Peter L. , Wigger Erin , Garcia‐Rivas Javier , Israel Leslie , Baker Dean B. 
Published: January 2013

AbstractBackgroundFirefighters, as an occupational group, have one of the highest prevalence rates of obesity. A qualitative study investigated occupational and health behavioral determinants of obesity among firefighters.MethodsFour focus groups were conducted with firefighters of every rank as Phase I of the FORWARD study which was designed to assess health behavioral and occupational characteristics related to obesity in firefighters.ResultsAnalysis revealed five main themes of central importance to firefighters: (1) fire station eating culture; (2) night calls and sleep interruption; (3) supervisor leadership and physical fitness; (4) sedentary work; and (5) age and generational influences.ConclusionThe results showed a strong interrelationship between occupational and health behavioral causes of obesity in firefighters. The relevance of these qualitative findings are discussed along with the implications for future obesity interventions with firefighters. Am. J. Ind. Med. 56:776–790, 2013. © 2013 Wiley Periodicals, Inc.
Anti‐clockwise rotating shift work and health: Would you prefer 3‐shift or 4‐shift operation?
Authors: Mauss Daniel , Litaker David , Jarczok Marc N. , Li Jian , Bosch Jos A. , Fischer Joachim E. 
Published: January 2013

AbstractBackgroundWe explored the association between work schedules involving nightshifts and selected measures of health and whether these associations differed among those working in either 3‐ or 4‐shift cycles.MethodsEmployees at a German industrial company who worked on a fixed daytime schedule or on one involving nightshifts were invited to participate in this cross‐sectional study. Work schedules involving a nightshift were organized into either 3 or 4 shifts rotated anti‐clockwise on a weekly basis. Health characteristics included a range of clinical and physiological measures and self‐reported data on stress and sleep quality. We assessed the independent association of work schedules involving any nightshift and these health characteristics in separate regression analyses, adjusting for age, gender, smoking, and alcohol consumption.ResultsNightshift work (N = 133) in general and 3‐shift‐work (N = 53) in particular was associated with decreased sleep quality (P < 0.001). Compared to those working daytime (N = 632), employees working on a 3‐shift cycle had higher adjusted odds of meeting the definition of metabolic syndrome (OR = 2.56 [1.38, 4.75]). Employees working 4‐shift cycles were somewhat less likely to have metabolic syndrome (OR = 1.22 [0.73, 2.05]) and had higher parasympathetic activity measured by heart rate variability (OR = 2.20 [1.04, 4.63]).ConclusionsOur data suggest important relationships between shift schedule and a selected group of objective and subjective health measures. Additional research that further clarifies potential mechanisms underlying these relationships is needed. Am. J. Ind. Med. 56:599–608, 2013. © 2013 Wiley Periodicals, Inc.
A combined study of genetic association and brain imaging on the DAOA gene in schizophrenia
Authors: Chen Jun , Xu Yong , Zhang Juan , Liu Zhifen , Xu Cheng , Zhang Kerang , Shen Yan , Xu Qi 
Published: January 2013

AbstractWhile there has been no objective biomarker available for both diagnosis and prognosis of schizophrenia, compelling evidence suggests that the glutamatergic system may influence susceptibility to schizophrenia. To test genetic association of the glutamatergic system with schizophrenia and abnormal brain activities in resting‐state patients with schizophrenia, a two‐stage association study was performed in 454 patients and 480 controls, followed by regional homogeneity (ReHo) analysis of resting‐state functional magnetic resonance imaging in 48 first‐episode medication‐free patients and 43 well‐matched controls. The differences in ReHo between genotypes of interest were initially tested by the Student's t‐test and the 2 × 2 (genotypes × disease status) ANOVA was then performed to identify the main effects of genotypes, disease status and their interactions in schizophrenia. The stage‐1 study showed association of the DAOA and PSEN2 genes with schizophrenia in a small sample; the stage‐2 study with an expanded sample confirmed the disease association for 2‐SNP and 3‐SNP haplotypes, and the cis‐phase interactions between rs2391191 and some other SNPs in the DAOA gene. Four clusters with altered ReHo in the bilateral culmen, left putamen and left cuneus were associated with rs2391191. Main effects of rs2391191 genotypes were found in the left putamen. The left cuneus showed a genotype × disease status interaction. In conclusion, the DAOA gene may confer genetic risk of schizophrenia and associate with the altered ReHo in schizophrenia; genotype effect and its interaction with disease status may contribute to the altered ReHo, leading to specific ReHo in schizophrenic brain due to glutamatergic modulation. © 2013 Wiley Periodicals, Inc.
Probing the reinforcing mechanism of graphene and graphene oxide in natural rubber
Authors: Li Fayong , Yan Ning , Zhan Yanhu , Fei Guoxia , Xia Hesheng 
Published: January 2013

AbstractNatural rubber (NR) containing graphene (GE) and graphene oxide (GO) were prepared by latex mixing. The in situ chemically reduction process in the latex was used to realize the conversion of GO to GE. A noticeable enhancement in tensile strength was achieved for both GO and GE filled NR systems, but GE has a better reinforcing effect than GO. The strain‐induced crystallization was evaluated by synchrotron wide‐angle X‐ray diffraction. Increased crystallinity and special strain amplification effects were observed with the addition of GE. The incorporation of GE produces a faster strain‐induced crystallization rate and a higher crystallinity compared to GO. The entanglement‐bound tube model was used to characterize the chain network structure of composites. It was found that the contribution of entanglement to the conformational constraint increases and the network molecular parameters changes with the addition of GE and GO, while GE has a more evident effect than GO. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Performance of flame retardancy silk modified with water‐soluble vinyl phosphoamide
Authors: Guan Jinping , Chen Guoqiang 
Published: January 2013

AbstractIn this article, a water‐soluble flame retardant monomer dimethyl(methacryloyloxyethyl)phosphoramidate (DMMEPN) was synthesized and applied onto silk fabric via graft copolymerization technique initiated with potassium persulfate (KPS). The results of attenuated total reflection infrared spectroscopy (ATR), scanning electron microscope (SEM) and energy dispersive X‐ray spectroscopy (EDS) indicated that DMMEPN was successfully grafted onto silk fiber surface. X‐ray diffraction (XRD) patterns showed that grafting process didn't change the crystalline structure of silk fibers and the reaction mainly occurred at the amorphous region of silk fibers. DMMEPN grafted silk fabric exhibited self‐extinguish property when ignited with a candle like fire with LOI of 32.38% and could pass vertical flammability test with char length of 42 mm. Thermal gravimetric analysis showed that grafted silk fibers had different thermal decomposition mode with control silk fibers and tended to produce more char after combustion. This article also investigated the physical properties like whiteness index, hygroscopicity, and tensile strength of grafted silk fabrics. The results showed that physical properties had some loss but had no negative effect on final uses. Laundering durability test demonstrated treated silk fabrics still showed flame retardancy after enduring 30 hand wash cycles. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Rituximab Therapy for Primary Sjögren's Syndrome: An Open‐Label Clinical Trial and Mechanistic Analysis
Authors: St.Clair E. William , Levesque Marc C. , Prak Eline T. Luning , Vivino Frederick B. , Alappatt Chacko J. , Spychala Meagan E. , Wedgwood Josiah , McNamara James , Moser Sivils Kathy L. , Fisher Lytia , Cohen Philip ,   for the Autoimmunity Centers of Excellence
Published: January 2013

AbstractObjectiveTo study the safety and clinical efficacy of rituximab therapy for primary Sjögren's syndrome, as well as to investigate its mechanisms.MethodsPatients with primary Sjögren's syndrome were enrolled in an open‐label trial, were given rituximab (1 gm) infusions on days 1 and 15, and were monitored through week 52. The primary end point was safety, with secondary end points evaluating clinical and biologic efficacy. Blood was obtained for enumeration of lymphocyte subsets, measurement of serum autoantibody and BAFF levels, and analysis of gene expression.ResultsTwelve female patients with primary Sjögren's syndrome were administered rituximab. They had a median age of 51 years (range 34–69 years) and a median disease duration of 8.0 years (range 2–18 years). We observed no unexpected toxicities from the rituximab therapy. Modest improvements were observed at week 26 in patient‐reported symptoms of fatigue and oral dryness, with no significant improvement in the objective measures of lacrimal and salivary gland function. The recovery of blood B cells following the nadir from rituximab therapy was characterized by a predominance of transitional B cells and a lack of memory B cells. While blood B cell depletion was associated with an increase in serum BAFF levels, no significant changes were observed in the levels of serum anti‐Ro/SSA, anti‐La/SSB, and anti–type 3 muscarinic acetylcholine receptor autoantibodies or in the blood interferon signature.ConclusionIn patients with primary Sjögren's syndrome, a single treatment course of rituximab was not associated with any unexpected toxicities and led to only modest clinical benefits despite effective depletion of blood B cells.
Deletion Variants of RABGAP1L, 10q21.3, and C4 Are Associated With the Risk of Systemic Lupus Erythematosus in Korean Women
Authors: Kim Ji‐Hong , Jung Seung‐Huyn , Bae Joon Seol , Lee Hye‐Soon , Yim Seon‐Hee , Park So‐Yeon , Bang So‐Young , Hu Hae‐Jin , Shin Hyoung Doo , Bae Sang‐Cheol , Chung Yeun‐Jun 
Published: January 2013

AbstractObjectiveSeveral copy number variations (CNVs) have been found to be associated with systemic lupus erythematosus (SLE) through the target gene approach. However, genome‐wide features of CNVs and their role in the risk of SLE remain unknown. The aim of this study was to identify SLE‐associated CNVs in Korean women.MethodsGenome‐wide assessments of CNVs were performed in 382 SLE patients and 191 control subjects, using an Illumina HumanHap610 BeadChip genotyping platform. SLE‐associated CNV regions that were identified by genome‐wide association study (GWAS) were replicated in quantitative polymerase chain reaction (PCR) and deletion‐typing PCR analyses in an independent sample set comprising 564 SLE patients and 511 control subjects.ResultsOf 144 common CNV regions, 3 deletion‐type CNV regions in 1q25.1, 8q23.3, and 10q21.3 were found to be significantly associated with SLE by GWAS analysis. In the independent replication, the CNV regions in 1q25.1 (RABGAP1L) and 10q21.3 were successfully replicated (odds ratio [OR] 1.30, P = 0.038 and OR 1.90, P = 3.6 × 10−5, respectively), and the associations were confirmed again by deletion‐typing PCR. The CNV region in the C4 gene, which showed a potential association in the discovery stage, was included in the replication analysis and was found to be significantly associated with the risk of SLE (OR 1.88, P = 0.01). Through deletion‐typing PCR, the exact sizes and breakpoint sequences of the deletions were defined. Individuals with the deletions in all 3 loci (RABGAP1L, 10q21.3, and C4) had a much higher risk of SLE than did those without any deletions in the 3 loci (OR 5.52, P = 3.9 × 10−4).ConclusionThese CNV regions can be useful to identify the pathogenic mechanisms of SLE, and might be used to more accurately predict the risk of SLE by taking into consideration their synergistic effects on disease susceptibility.
Acid‐Sensing Ion Channel 3 Deficiency Increases Inflammation but Decreases Pain Behavior in Murine Arthritis
Authors: Sluka Kathleen A. , Rasmussen Lynn A. , Edgar Meghan M. , O'Donnell James M. , Walder Roxanne Y. , Kolker Sandra J. , Boyle David L. , Firestein Gary S. 
Published: January 2013

AbstractObjectiveThrough its location on nociceptors, acid‐sensing ion channel 3 (ASIC‐3) is activated by decreases in pH and plays a significant role in musculoskeletal pain. We recently showed that decreases in pH activate ASIC‐3 located on fibroblast‐like synoviocytes (FLS), which are key cells in the inflammatory process. The purpose of this study was to test whether ASIC‐3–deficient mice with arthritis have altered inflammation and pain relative to controls.MethodsCollagen antibody–induced arthritis (CAIA) was generated by injection of an anti–type II collagen antibody cocktail. Inflammation and pain parameters in ASIC‐3−/− and ASIC‐3+/+ mice were assessed. Disease severity was assessed by determining clinical arthritis scores, measuring joint diameters, analyzing joint histology, and assessing synovial gene expression by quantitative polymerase chain reaction analysis. Cell death was assessed with a Live/Dead assay of FLS in response to decreases in pH. Pain behaviors in the mice were measured by examining withdrawal thresholds in the joints and paws and by measuring their physical activity levels.ResultsSurprisingly, ASIC‐3−/− mice with CAIA demonstrated significantly increased joint inflammation, joint destruction, and expression of interleukin‐6 (IL‐6), matrix metalloproteinase 3 (MMP‐3), and MMP‐13 in joint tissue as compared to ASIC‐3+/+ mice. ASIC‐3+/+ FLS showed enhanced cell death when exposed to pH 6.0 in the presence of IL‐1β, which was abolished in ASIC‐3−/− FLS. Despite enhanced disease severity, ASIC‐3−/− mice did not develop mechanical hypersensitivity of the paw and showed greater levels of physical activity.ConclusionOur findings are consistent with the hypothesis that ASIC‐3 plays a protective role in the inflammatory arthritides by limiting inflammation through enhanced synoviocyte cell death, which reduces disease severity, and through the production of pain, which reduces joint use.
Wood pellet market and trade: a global perspective
Authors: Goh Chun Sheng , Junginger Martin , Cocchi Maurizio , Marchal Didier , Thrän Daniela , Hennig Christiane , Heinimö Jussi , Nikolaisen Lars , Schouwenberg Peter‐Paul , Bradley Douglas , Hess Richard , Jacobson Jacob , Ovard Leslie , Deutmeyer Michael 
Published: January 2013

AbstractThis perspective provides an overview of wood pellet markets in a number of countries of high significance, together with an inventory of market factors and relevant past or existing policies. In 2010, the estimated global wood pellet production and consumption were close to 14.3 Mt (million metric tonnes) and 13.5 Mt, respectively, while the global installed production capacity had reached over 28 Mt. Two types of pellets are mainly traded (i) for residential heating and (ii) for large‐scale district heating or co‐firing installations. The EU was the primary market, responsible for nearly 61% and 85% of global production and consumption, respectively in 2010. EU markets were divided according to end use: (i) residential and district heating, (ii) power plants driven market, (iii) mixed market, and (iv) export‐driven countries. North America basically serves as an exporter, but also with significant domestic consumption in USA. East Asia is predicted to become the second‐largest consumer after the EU in the near future. The development perspective in Latin America remains unclear. Five factors that determine the market characteristics are: (i) the existence of coal‐based power plants, (ii) the development of heating systems, (iii) feedstock availability, (iv) interactions with wood industry, and (v) logistics factor. Furthermore, intervention policies play a pivotal role in market development. The perspective of wood pellets industry was also analyzed from four major aspects: (i) supply potential, (ii) logistics issues, (iii) sustainability considerations, and (iv) technology development. © 2013 Society of Chemical Industry and John Wiley & Sons, Ltd