bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: I2‐Catalyzed Oxidative Cross‐Coupling of Methyl Ketones and Benzamidines Hydrochloride: A Facile Access to α‐Ketoimides.
Authors: Wu Xia , Gao Qinghe , Liu Shan , Wu Anxin 
Published: November 2014

AbstractThis iodine catalyzed oxidative amidation is advantageous with regards to operational simplicity, metal‐ and peroxide‐free conditions, and high yields.
ChemInform Abstract: Copper‐Catalyzed Esterification of Alkylbenzenes with Cyclic Ethers and Cycloalkanes via C(sp3)—H Activation Following Cross‐Dehydrogenative Coupling.
Authors: Rout Saroj Kumar , Guin Srimanta , Ali Wajid , Gogoi Anupal , Patel Bhisma K. 
Published: November 2014

AbstractThe synthesis of α‐acyloxy ethers from simple solvents as reactants is reported.
ChemInform Abstract: Broensted Acid Mediated Nitrogenation of Propargylic Alcohols: An Efficient Approach to Alkenyl Nitriles.
Authors: Huang Xiaoqiang , Jiao Ning 
Published: November 2014

AbstractA new approach to alkenyl nitriles under mild and metal‐free conditions via the direct incorporation of a nitrogen atom into propargylic alcohols is described.
ChemInform Abstract: Enantioselective Transformation of Allyl Carbonates into Branched Allyl Carbamates by Using Amines and Recycling CO2 under Iridium Catalysis.
Authors: Zheng Sheng‐Cai , Zhang Min , Zhao Xiao‐Ming 
Published: November 2014

AbstractA domino reaction of allyl carbonates and amines is developed to yield enantioenriched branched allyl carbonates.
ChemInform Abstract: Aromatics to Bis‐triquinane: A Tandem Oxidative Dearomatization of Bis‐Phenol, Cycloaddition, Photorearrangement and a Rapid Entry into Carbocyclic Framework of Xeromphalinone E.
Authors: Singh Deepak , Chaudhari Umesh V. , Deota Pradeep T. 
Published: November 2014

AbstractThis describes attempts to synthesize compound (I), which is structurally related to Xeromphalinone E.
ChemInform Abstract: Stereocontrolled Construction of Six Vicinal Stereogenic Centers on Spiropyrazolones via Organocascade Michael/Michael/1,2‐Addition Reactions.
Authors: Chauhan Pankaj , Mahajan Suruchi , Loh Charles C. J. , Raabe Gerhard , Enders Dieter 
Published: November 2014

AbstractA one‐pot protocol for the synthesis of spiropyrazolones via sequential reaction of β‐dicarbonyl compounds, nitroalkenes, and pyrazolones catalyzed by a cinchona derived aminosquaramide and DBU is developed.
ChemInform Abstract: Access to β‐Lactams by Enantioselective Palladium(0)‐Catalyzed C(sp3)—H Alkylation.
Authors: Pedroni Julia , Boghi Michele , Saget Tanguy , Cramer Nicolai 
Published: November 2014

AbstractThis method exhibits a palladium‐catalyzed C—H functionalization for the challenging asymmetric formation of saturated C(sp3)—C(sp3) bonds via a strain‐building reductive elimination resulting in the formation of the four‐membered ring of β‐lactams.
ChemInform Abstract: “One‐Pot” Access to Dihydrofurans via Tandem Oxidative Difunctionalization and Ring Contraction of Aminopyrans.
Authors: Mandha Santhosh Reddy , Alla Manjula , Nanubolu Jagadeesh Babu 
Published: November 2014

AbstractThe sequential addition of NCS and a base to 2‐amino‐4H‐pyran derivatives (I) and (IV) in alcohol medium affords dihydrofurans (III) and (V), resp., in good yields.
ChemInform Abstract: Palladium‐Catalyzed Tandem Intramolecular Oxy/Amino‐Palladation/Isocyanide Insertion: Synthesis of α‐Benzofuranyl/Indolylacetamides.
Authors: Thirupathi Nuligonda , Hari Babu Madala , Dwivedi Vikas , Kant Ruchir , Sridhar Reddy Maddi 
Published: November 2014

AbstractThe synthesis of α‐benzofuranylacetamides from phenol derivatives and isocyanides is developed.
ChemInform Abstract: Diels—Alder Reaction of 1,3‐Diarylbenzo[c]furans with Thiophene S,S‐Dioxide/Indenone Derivatives: A Facile Preparation of Substituted Dibenzothiophene S,S‐Dioxides and Fluorenones.
Authors: Nandakumar Meganathan , Karunakaran Jayachandran , Mohanakrishnan Arasambattu K. 
Published: November 2014

AbstractOne pot syntheses of substituted dibenzothiophene S,S‐dioxides and fluorenones are successfully achieved by Diels—Alder reaction of benzo[c]furans with thiophene S,S‐dioxides and indenones, respectively.
ChemInform Abstract: Transition‐Metal‐Free Oxidative Carboazidation of Acrylamides via Cascade C—N and C—C Bond‐Forming Reactions.
Authors: Qiu Jun , Zhang Ronghua 
Published: November 2014

AbstractThe title reaction provides access to azido oxindoles using K2S2O8 as the oxidant and NaN3 as a azide source.
ChemInform Abstract: Organocatalytic Enantioselective Construction of Multi‐Functionalized Spiro Oxindole Dienes.
Authors: Huang Xiao‐Fei , Zhang Ya‐Fei , Qi Zheng‐Hang , Li Nai‐Kai , Geng Zhi‐Cong , Li Kun , Wang Xing‐Wang 
Published: November 2014

AbstractA diastereo‐ and enantioselective domino Michael‐cyclization‐tautomerization reaction of isatylidene malononitriles (I) and (IV) with α,α‐dicyanoalkenes catalyzed by a chinchona alkaloid‐derived bifunctional catalyst is reported.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling Reactions of Potassium N‐Methyltrifluoroborate Isoindolin‐1‐one with Aryl and Heteroaryl Chlorides.
Authors: Nadaf Rashid N. , Seapy Dave G. 
Published: November 2014

AbstractThe title borate (III) undergoes Pd‐catalyzed Suzuki—Miyaura cross‐coupling with aryl and heteroaryl chlorides leading to N‐benzylisoindolin‐1‐ones under mild reaction conditions.
ChemInform Abstract: Rapid and Efficient Synthesis of 3,3‐Di(1H‐indol‐3‐yl)indolin‐2‐ones and 2,2‐Di(1H‐indol‐3‐yl)‐2H‐acenaphthen‐1‐ones Catalyzed by p‐TSA.
Authors: Yu Jiangxia , Shen Tianhua , Lin Yan , Zhou Yongbing , Song Qingbao 
Published: November 2014

AbstractThe title compounds (III) and (V) are obtained by reaction of various isatins or acenaphthenequinone, resp., with indoles under mild reaction conditions.
ChemInform Abstract: Copper‐Mediated Tandem Oxidative C(sp2)—H/C(sp)—H Alkynylation and Annulation of Arenes with Terminal Alkynes.
Authors: Dong Jiaxing , Wang Fei , You Jingsong 
Published: November 2014

AbstractThe title reaction features a wide substrate scope and proceeds with exclusive chemo‐, regio‐, and stereoselectivity to form isoindole derivatives (III) and (V).
ChemInform Abstract: Synthesis of Isatins by I2/TBHP Mediated Oxidation of Indoles.
Authors: Zi You , Cai Zhong‐Jian , Wang Shun‐Yi , Ji Shun‐Jun 
Published: November 2014

AbstractA convenient, simple, and metal‐free protocol for the synthesis of isatins by direct oxidation of commercially available indoles under mild conditions is developed.
ChemInform Abstract: Synthesis and Biological Evaluation of Some 2‐(3,5‐Dimethyl‐1H‐pyrazol‐1‐yl)‐1‐arylethanones: Antibacterial, DNA Photocleavage, and Anticancer Activities.
Authors: Kumar Vinod , Kaur Kamalneet , Karelia Deepkamal N. , Beniwal Vikas , Gupta Girish Kumar , Sharma Arun K. , Gupta Akhilesh Kumar 
Published: November 2014

AbstractA novel, mild, green, fast, and highly regioselective one‐pot protocol to prepare title compounds (III) is developed.
ChemInform Abstract: When Aryldiazonium Salts Meet Vinyl Diazoacetates: A Cobalt‐Catalyzed Regiospecific Synthesis of N‐Arylpyrazoles.
Authors: Guo Haiheng , Zhang Daming , Zhu Chenghao , Li Jian , Xu Guangyang , Sun Jiangtao 
Published: November 2014

AbstractThe cobalt‐catalyzed coupling reaction of vinyl diazoacetates and aryl diazonium salts affords arylpyrazoles.
ChemInform Abstract: Regioselective Cycloaddition of Trifluorodiazoethane with Electron‐Deficient Allenic Esters and Ketones: Access to CF3‐Substituted Pyrazolines and Pyrazoles.
Authors: Zhang Fa‐Guang , Wei Yi , Yi Yu‐Ping , Nie Jing , Ma Jun‐An 
Published: November 2014

AbstractA highly regioselective cycloaddition procedure of electron‐deficient allenes with trifluorodiazoethane is developed.
ChemInform Abstract: Design and Optimization of Ecofriendly One‐Pot Synthesis of 2,4,5‐Triaryl‐1H‐imidazoles by Three‐Component Condensation Using Response Surface Methodology.
Authors: Kumar T. Durai Ananda , Yamini N. , Subrahmanyam C. V. S. , Satyanarayana K. 
Published: November 2014

AbstractAn extensive statistical method is used to optimize the reaction parameters (e.g. catalyst and catalyst concentration, solvent and solvent volume) for the synthesis of 2,4,5‐triaryl‐1H‐imidazoles (III).
ChemInform Abstract: Rhodium‐Catalyzed Regio‐ and Stereoselective Oxyamination of Dienes via Tandem Aziridination/Ring‐Opening of Dienyl Carbamates.
Authors: Guasch Joan , Diaz Yolanda , Matheu M. Isabel , Castillon Sergio 
Published: November 2014

AbstractOpposite regioselectivity is observed depending on the whether Rh2(OAc)4 or bulky Rh2(OPiv)4 is used as a catalyst.
ChemInform Abstract: Synthesis of 2‐C‐Substituted Benzothiazoles via a Copper‐Promoted Domino Condensation/S‐Arylation/Heterocyclization Process.
Authors: Xiang Haoyue , Qi Jin , He Qian , Jiang Min , Yang Chunhao , Deng Lianfu 
Published: November 2014

AbstractThe reaction yields are severely affected by the substituents of (I).
ChemInform Abstract: The Use of a Mitsunobu Reagent for the Formation of Heterocycles: A Simple Method for the Preparation of 3‐Alkyl‐5‐aryl‐1,3,4‐oxadiazol‐2(3H)‐ones from Carboxylic Acids.
Authors: Sugimoto Osamu , Arakaki Tomoyo , Kamio Hiroka , Tanji Ken‐ichi 
Published: November 2014

AbstractThe reaction proceeds smoothly when Mitsunobu reagents with smaller alkyl groups are used.
ChemInform Abstract: Direct Arylation of Pyridines Without the Use of a Transition Metal Catalyst.
Authors: Li Yahui , Liu Wei , Kuang Chunxiang 
Published: November 2014

AbstractThe direct arylation of electron‐deficient heterocycles, such as (I), (V), (VIII), and (X) with arylhydrazine hydrochlorides (II) without any catalyst and co‐oxidant is described.
ChemInform Abstract: Ruthenium‐Catalyzed Cyclization of Ketoxime Acetates with DMF for Synthesis of Symmetrical Pyridines.
Authors: Zhao Mi‐Na , Hui Rong‐Rong , Ren Zhi‐Hui , Wang Yao‐Yu , Guan Zheng‐Hui 
Published: November 2014

AbstractThe synthesis of tetrasubstituted symmetrical pyridines by a novel ruthenium‐catalyzed cyclization of ketoxime carboxylates with DMF is described.
ChemInform Abstract: Asymmetric Synthesis of Tetrahydroquinolines Through Supramolecular Organocatalysis.
Authors: Ramachary Dhevalapally B. , Shruthi Kodambahalli S. 
Published: November 2014

AbstractMedicinally important title compounds (IV) are prepared via enantioselective Michael addition of acetone to azido‐nitrovinyl‐benzenes (I), followed by reductive amination.
ChemInform Abstract: Recyclable Nano Copper Oxide Catalyzed Synthesis of Quinoline‐2,3‐dicarboxylates under Ligand Free Conditions.
Authors: Venkanna Avudoddi , Swapna Kokkirala , Rao Pallapothula Venkateswar 
Published: November 2014

Abstract16 Title compounds are prepared using CuO nanoparticles as catalyst.
ChemInform Abstract: L‐Proline Catalyzed Multicomponent Reactions: Facile Access to 2H‐Benzo[g]pyrazolo[3,4‐b]quinoline‐5,10(4H,11H)‐dione Derivatives.
Authors: Karamthulla Shaik , Pal Suman , Parvin Tasneem , Choudhury Lokman H. 
Published: November 2014

Abstract16 Title compounds of type (IV) are prepared using L‐proline as catalyst.
ChemInform Abstract: An Efficient Domino Knoevenagel/Hetero‐Diels—Alder Route to Some Novel Thiochromenoquinoline‐Fused Polyheterocycles
Authors: Parmar Narsidas J. , Labana Balvantsingh M. , Barad Hitesh A. , Kant Rajni , Gupta Vivek K. 
Published: November 2014

Abstractunder solvent‐free reaction conditions
ChemInform Abstract: N‐Chlorosuccinimide‐Promoted Regioselective Sulfenylation of Imidazoheterocycles at Room Temperature.
Authors: Ravi Chitrakar , Chandra Mohan Darapaneni , Adimurthy Subbarayappa 
Published: November 2014

AbstractThe novel protocol allows the regioselective sulfenylation of a wide variety of imidazoheterocycles under mild and metal‐free reaction conditions.
ChemInform Abstract: Efficient Access to 2,3‐Diarylimidazo[1,2‐a]pyridines via a One‐Pot, Ligand‐Free, Palladium‐Catalyzed Three‐Component Reaction under Microwave Irradiation.
Authors: Wang Yuanxiang , Frett Brendan , Li Hong‐yu 
Published: November 2014

AbstractA convenient process to construct 2,3‐diarylimidazo[1,2‐a]pyridines through a Pd‐catalyzed three‐component reaction of 2‐aminopyridine, 2‐bromoacetophenones, and reactive aryl bromides is developed.
ChemInform Abstract: Gold‐Catalyzed Cascade Cyclization of (Azido)ynamides: An Efficient Strategy for the Construction of Indoloquinolines.
Authors: Tokimizu Yusuke , Oishi Shinya , Fujii Nobutaka , Ohno Hiroaki 
Published: November 2014

AbstractA novel method for the synthesis of indoloquinoline compounds via the gold‐catalyzed cascade cyclization of (azido)ynamides is described.
ChemInform Abstract: Rh(III)‐Catalyzed Cascade Oxidative Olefination/Cyclization of Picolinamides and Alkenes via C—H Activation.
Authors: Cai Shangjun , Chen Chao , Shao Peng , Xi Chanjuan 
Published: November 2014

AbstractRh(III)‐catalyzed intermolecular oxidative alkenylation/cyclization of picolinamides and alkenes with high regio‐ and stereoselectivity to produce pyrido pyrrolone derivatives in good to excellent yields.
ChemInform Abstract: Direct Synthesis of 5‐ and 6‐Substituted 2‐Aminopyrimidines as Potential Non‐natural Nucleobase Analogues.
Authors: Radhakrishnan K. , Sharma Namita , Kundu Lal Mohan 
Published: November 2014

Abstract15 Isocytosines of type (III) and (V) are prepared under microwave irradiation under solventless conditions.
ChemInform Abstract: General and Rapid Pyrimidine Condensation by Addressing the Rate Limiting Aromatization.
Authors: Fandrick Daniel R. , Reinhardt Delia , Desrosiers Jean‐Nicolas , Sanyal Sanjit , Fandrick Keith R. , Ma Shengli , Grinberg Nelu , Lee Heewon , Song Jinhua J. , Senanayake Chris H. 
Published: November 2014

AbstractThe amidines are used in form of their hydrochlorides.
ChemInform Abstract: Amino Functionalized Mesoporous Silica Decorated with Iron Oxide Nanoparticles as a Magnetically Recoverable Nanoreactor for the Synthesis of a New Series of 2,4‐Diphenylpyrido[4,3‐d]pyrimidines.
Authors: Shadjou Nasrin , Hasanzadeh Mohammad 
Published: November 2014

AbstractThe advantages of the present method are high yields, simplicity, and easy work‐up.
ChemInform Abstract: Access to Cyclobutene‐Fused Azepines Through Au‐Catalyzed Cycloisomerization of Stable Alkyne Tethered Ketene N,N‐Acetals.
Authors: Nayak Sanatan , Ghosh Nayan , Sahoo Akhila K. 
Published: November 2014

AbstractThe synthesis of N‐protected alkyne‐tethered ketene‐N,N‐acetals from N‐protected propargylamines and 3‐bromopropiolates is demonstrated for the first time.
ChemInform Abstract: Regioselective Synthesis of Polycyclic Aza‐Oxa and Aza‐Oxa‐Thia Heteroarenes as Colo‐205 and HepG2 Carcinoma Cells Growth Inhibitors.
Authors: Ram Vishnu Ji , et al. et al. 
Published: November 2014

AbstractAn elegant regioselective synthesis of fused tetra‐ and pentacyclic heteroarenes based on ring transformation reactions of appropriate lactones with hydrazine is given.
ChemInform Abstract: Solvent‐Controlled Lithiation of P=C—N‐Heterocycles: Synthesis of Mono‐ and Bis(trimethylsilyl)‐tert‐butyl‐dihydrobenzazaphospholes — A New Type of Highly Bulky and Basic Phosphine Ligands.
Authors: Ghalib Mohammed , Jones Peter G. , Heinicke Joachim W. 
Published: November 2014

AbstractThe reactions of 1,3‐benzazaphospholes with tBuLi and trimethylchlorosilane are investigated.
ChemInform Abstract: Metal‐Free Azaphosphaannulation of Phosphonamides Through Intramolecular Oxidative C—N Bond Formation.
Authors: Kim Yea Rin , Cho Seungyoon , Lee Phil Ho 
Published: November 2014

AbstractThe synthesis of novel benzazaphosphol‐3‐one 1‐oxides via metal‐free oxidative radical azaphosphaannulation is described.
ChemInform Abstract: α‐Organylchalcogenation of Aldehydes and Ketones with Diorganyl Dichalcogenides Promoted by K3PO4.
Authors: Movassagh Barahman , Yousefi Ali 
Published: November 2014

AbstractVarious aldehydes and ketones react with diorganyl dichalcogenides under mild reaction conditions leading to the corresponding α‐organylseleno and α‐arylthio carbonyl compounds.
ChemInform Abstract: Simple and Convenient Method for the Synthesis of Aryltellurophosphates Catalyzed by Cesium Hydroxide.
Authors: Wang Ling Xiao , Su Liu , Li Jian Hua , Li Ning Bo , Peng Zhi Hong , Li Yuan Yuan , Xu Xin Hua 
Published: November 2014

AbstractThe title compounds (III) are obtained by Cs‐catalyzed reactions of dialkyl phosphites with diaryl ditellurides.
ChemInform Abstract: Unified Approach to the Asymmetric Synthesis of Higher Homologues of (3‐Quinolyl)‐alanine.
Authors: Chattopadhyay Shital K. , Kundu Indranil 
Published: November 2014

AbstractThree homologues of the important α‐amino acid (3‐quinolyl)alanine, ((R)‐V) and ((S)‐XI), are synthesized by a new protocol involving Heck‐type arylation of 3‐bromoquinoline as the key step.
ChemInform Abstract: Synthesis and Characterization of Chloralose‐Derived Thiosemicarbazones and Semicarbazones and Investigation of Their Antimicrobial Properties.
Authors: Yetgin Can Emre , Oskay Mustafa , Ay Kadir 
Published: November 2014

AbstractThe synthesized (thio)semicarbazone derivatives such as (III) display moderate antimicrobial and antifungal activities.
ChemInform Abstract: Total Syntheses of Rubiginone A2, C2, and Fujianmycin A.
Authors: Vanga Devendar G. , Kaliappan Krishna P. 
Published: November 2014

AbstractRubiginone A2 (Ia), rubiginone C2 (Ib) and fujianmycin A (Ic) are synthesized enantioselectively starting from ((2R,3R)‐3‐methyloxiran‐2‐yl)methanol in 14, 12 and 16% yield, respectively.
ChemInform Abstract: Divergent Synthesis of Bioactive Resorcinols Isolated from the Fruiting Bodies of Hericium erinaceum: Total Syntheses of Hericenones A, B, and I, Hericenols B—D, and Erinacerins A and B.
Authors: Kobayashi Shoji , Tamanoi Hidetsugu , Hasegawa Yuichi , Segawa Yusuke , Masuyama Araki 
Published: November 2014

AbstractEight bioactive ingredients of the mushroom H.
ChemInform Abstract: Hydrogen Storage Properties of LaMgNi3.6M0.4 (M: Ni, Co, Mn, Cu, Al) Alloys.
Authors: Yang Tai , Zhai Tingting , Yuan Zeming , Bu Wengang , Xu Sheng , Zhang Yanghuan 
Published: November 2014

AbstractLaMgNi3.6M0.4 (M: Ni, Co, Mn, Cu, Al) alloys are prepared by induction melting of the elements.
ChemInform Abstract: Our Recent Progress on the Intramolecular Diels—Alder Reaction Approach in Natural Products Synthesis: Synthetic Studies of the Octahydronaphthalene Substructure of Versipelostatins and the A/B/C‐Tricyclic Substructure of GKK1032s
Authors: Tadano Kin‐Ichi 
Published: November 2014

AbstractReview: [66 refs.
ChemInform Abstract: The Impact of Structural Relaxation on Spin Polarization and Magnetization Reversal of Individual Nanostructures Studied by Spin‐polarized Scanning Tunneling Microscopy
Authors: Sander Dirk , Phark Soo‐Hyon , Corbetta Marco , Fischer Jeison A. , Oka Hirofumi , Kirschner Juergen 
Published: November 2014

AbstractReview: [102 refs.]
Chiral 1,2‐Dialkenyl Diaziridines: Synthesis, Enantioselective Separation, and Nitrogen Inversion Barriers
Authors: Zawatzky Kerstin , Kamuf Matthias , Trapp Oliver 
Published: November 2014

Abstracttrans‐1,2‐Disubstituted diaziridines form stable enantiomers at ambient conditions because of the two stereogenic pyramidal nitrogen atoms. Functionalized trans‐1,2‐disubstituted diaziridines can be utilized as a chiral switching moiety between two enantiomeric states in more complex molecular structures. However, the synthesis of functionalized diaziridines is quite challenging, because of the limited tolerance of reaction conditions that can be applied. Here we present a strategy to make trans‐1,2‐disubstituted diaziridines accessible as versatile building blocks in C‐C‐bond formations, i.e., the Heck reaction, and therefore introducing aryl substituents. The synthesis of trans‐1,2‐dialkenyl diaziridines with terminal alkenyl substituents and their stereodynamic properties are described. Chirality 27:156–162, 2015. © 2014 Wiley Periodicals, Inc.
The Discovery of a Highly Selective 5,6,7,8‐Tetrahydrobenzo[4,5]thieno[2,3‐d]pyrimidin‐4(3H)‐one SIRT2 Inhibitor that is Neuroprotective in an in vitro Parkinson’s Disease Model
Authors: Di Fruscia Paolo , Zacharioudakis Emmanouil , Liu Chang , Moniot Sébastien , Laohasinnarong Sasiwan , Khongkow Mattaka , Harrison Ian F. , Koltsida Konstantina , Reynolds Christopher R. , Schmidtkunz Karin , Jung Manfred , Chapman Kathryn L. , Steegborn Clemens , Dexter David T. , Sternberg Michael J. E. , Lam Eric W.‐F. , Fuchter Matthew J. 
Published: November 2014

AbstractSirtuins, NAD+‐dependent histone deacetylases (HDACs), have recently emerged as potential therapeutic targets for the treatment of a variety of diseases. The discovery of potent and isoform‐selective inhibitors of this enzyme family should provide chemical tools to help determine the roles of these targets and validate their therapeutic value. Herein, we report the discovery of a novel class of highly selective SIRT2 inhibitors, identified by pharmacophore screening. We report the identification and validation of 3‐((2‐methoxynaphthalen‐1‐yl)methyl)‐7‐((pyridin‐3‐ylmethyl)amino)‐5,6,7,8‐tetrahydrobenzo[4,5]thieno[2,3‐d]pyrimidin‐4(3H)‐one (ICL‐SIRT078), a substrate‐competitive SIRT2 inhibitor with a Ki value of 0.62±0.15 μM and more than 50‐fold selectivity against SIRT1, 3 and 5. Treatment of MCF‐7 breast cancer cells with ICL‐SIRT078 results in hyperacetylation of α‐tubulin, an established SIRT2 biomarker, at doses comparable with the biochemical IC50 data, while suppressing MCF‐7 proliferation at higher concentrations. In concordance with the recent reports that suggest SIRT2 inhibition is a potential strategy for the treatment of Parkinson’s disease, we find that compound ICL‐SIRT078 has a significant neuroprotective effect in a lactacystin‐induced model of Parkinsonian neuronal cell death in the N27 cell line. These results encourage further investigation into the effects of ICL‐SIRT078, or an optimised derivative thereof, as a candidate neuroprotective agent in in vivo models of Parkinson’s disease.
Enhanced Performance of Mixed‐Matrix Membranes through a Graft Copolymer‐Directed Interface and Interaction Tuning Approach
Authors: Chi Won Seok , Kim Sang Jin , Lee Seung‐Joon , Bae Youn‐Sang , Kim Jong Hak 
Published: November 2014

AbstractHerein, a high performance mixed‐matrix membrane (MMM) is reported with simultaneously large improvements in the CO2 permeability by 880 % from 70.2 to 687.7 Barrer (1 Barrer=1×10−10 cm3 cm cm−2 s−1 cmHg−1) and CO2/N2 selectivity by 14.4 % from 30.5 to 34.9. These findings represent one of the most dramatic improvements ever reported for MMMs. These improvements are obtained through an interface and interaction tuning approach based on an amphiphilic grafted copolymer. Poly(vinyl chloride)‐g‐poly(oxyethylene methacrylate) (PVC‐g‐POEM) graft copolymer plays a key role as a soft organic matrix to provide good permeation properties, uniform distribution of zeolite imidazole frameworks‐8 (ZIF‐8), and better interfacial contact with inorganic compounds. In particular, the CO2/C3H8 and CO2/C3H6 selectivities reached 10.5 and 42.7, respectively, for PVC‐g‐POEM/ZIF (40 %) MMMs; this indicates that it could be a promising membrane material for the purification of C3 hydrocarbons.