bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magneto‐Acoustic Field‐Induced Unstable Interface of Magnetic Microswarm
Authors: Zhuang Rencheng , Zhou Dekai , Liu Junmin , Chang Xiaocong , Zhang Guangyu , Li Longqiu 
Published: July 2024

AbstractResearch on the interfacial instability of two‐phase systems can help in gaining a better understanding of various hydrodynamic instabilities in nature. However, owing to the nonlinear and complex spatiotemporal dynamics of the unstable interface, the instability is challenging to control and suppress. This paper presents a novel interfacial instability of the magnetic microswarm induced by the competition between the destabilizing effect of magnetic field and the stabilizing effect of acoustic field. The physics underlying this novel phenomenon is discussed by analyzing the contributions of the external fields. Unlike previous studies, this study demonstrates that the instability is independent of the interfacial force or diffusion effect and can persist without dissipation over time. The manipulation of the unstable interface is further achieved by adjusting the configuration of the magneto‐acoustic system. This approach can be used in thermal encoding metamaterials and has great potential applications in systems where the instability is detrimental.
PP2Ac Regulates Autophagy via Mediating mTORC1 and ULK1 During Osteoclastogenesis in the Subchondral Bone of Osteoarthritis
Authors: Zhang Haifeng , Ge Gaoran , Zhang Wei , Sun Houyi , Liang Xiaolong , Xia Yu , Du Jiacheng , Wu Zerui , Bai Jiaxiang , Yang Huilin , Yang Xing , Zhou Jun , Xu Yaozeng , Geng Dechun 
Published: July 2024

AbstractThe molecular mechanism underlying abnormal osteoclastogenesis triggering subchondral bone remodeling in osteoarthritis (OA) is still unclear. Here, single‐cell and bulk transcriptomics sequencing analyses are performed on GEO datasets to identify key molecules and validate them using knee joint tissues from OA patients and rat OA models. It is found that the catalytic subunit of protein phosphatase 2A (PP2Ac) is highly expressed during osteoclastogenesis in the early stage of OA and is correlated with autophagy. Knockdown or inhibition of PP2Ac weakened autophagy during osteoclastogenesis. Furthermore, the ULK1 expression of the downstream genes is significantly increased when PP2Ac is knocked down. PP2Ac‐mediated autophagy is dependent on ULK1 phosphorylation activity during osteoclastogenesis, which is associated with enhanced dephosphorylation of ULK1 Ser637 residue regulating at the post‐translational level. Additionally, mTORC1 inhibition facilitated the expression level of PP2Ac during osteoclastogenesis. In animal OA models, decreasing the expression of PP2Ac ameliorated early OA progression. The findings suggest that PP2Ac is also a promising therapeutic target in early OA.
Microbial Tryptophan Metabolites Ameliorate Ovariectomy‐Induced Bone Loss by Repairing Intestinal AhR‐Mediated Gut‐Bone Signaling Pathway
Authors: Chen Chuan , Cao Zheng , Lei Hehua , Zhang Cui , Wu Mengjing , Huang Shaohua , Li Xinzhi , Xie Denghui , Liu Maili , Zhang Limin , Chen Gang 
Published: July 2024

AbstractMicrobial tryptophan (Trp) metabolites acting as aryl hydrocarbon receptor (AhR) ligands are shown to effectively improve metabolic diseases via regulating microbial community. However, the underlying mechanisms by which Trp metabolites ameliorate bone loss via gut‐bone crosstalk are largely unknown. In this study, supplementation with Trp metabolites, indole acetic acid (IAA), and indole‐3‐propionic acid (IPA), markedly ameliorate bone loss by repairing intestinal barrier integrity in ovariectomy (OVX)‐induced postmenopausal osteoporosis mice in an AhR‐dependent manner. Mechanistically, intestinal AhR activation by Trp metabolites, especially IAA, effectively repairs intestinal barrier function by stimulating Wnt/β‐catenin signaling pathway. Consequently, enhanced M2 macrophage by supplementation with IAA and IPA secrete large amount of IL‐10 that expands from intestinal lamina propria to bone marrow, thereby simultaneously promoting osteoblastogenesis and inhibiting osteoclastogenesis in vivo and in vitro. Interestingly, supplementation with Trp metabolites exhibit negligible ameliorative effects on both gut homeostasis and bone loss of OVX mice with intestinal AhR knockout (VillinCreAhrfl/fl). These findings suggest that microbial Trp metabolites may be potential therapeutic candidates against osteoporosis via regulating AhR‐mediated gut‐bone axis.
Performance Enhancement of Tricalcium Phosphate Film for Bioelectronics with Bio‐Friendly Supercritical Fluids Desorption Technology
Authors: Peng Zehui , Wang Mingqiang , Li Lei , Duan Xinqing , Liu Huangbai , Wang Mingge , Wang Jie , Chang Chang‐Kuan 
Published: July 2024

AbstractIn the rapidly advancing field of bioelectronics, searching for materials that combine superior insulating properties with biocompatibility is crucial, especially for implantable electronic devices. Traditional insulators in mature CMOS processes, though effective, lack biocompatibility, necessitating the exploration of alternative materials. This study introduces tricalcium phosphate (Ca3(PO4)2), a primary component of human bones, and teeth, as an insulating layer material for the first time. High‐quality, thickness‐controlled Ca3(PO4)2 films are fabricated using magnetron sputtering, and their electrical insulation, stability, and optical transparency have been thoroughly evaluated. To further optimize the insulation performance of Ca3(PO4)2, particularly against residual impurities, and fabrication‐induced defects, a bio‐friendly low‐temperature supercritical fluid desorption (LTSCF‐Desorption) technique is developed, effectively removing impurities, repairing defects, and improving the interface states. After LTSCF‐Desorption treatment, the leakage current of the Ca3(PO4)2 films is reduced by 30%, along with the enhancements of the films' stability and transmittance. Further material analysis clarified the internal mechanisms behind the improvement of the Ca3(PO4)2 films. Overall, this study not only broadens the application scenarios of Ca3(PO4)2 in bioelectronics but also develops a bio‐friendly supercritical desorption technique, providing a new pathway for optimizing the performance of bioelectronic devices and materials.
Harnessing the Potential of (Quasi) Solid‐State Na‐Air/O₂ Batteries: Strategies and Future Directions for Next‐Generation Energy Storage Solutions
Authors: Yahia Mohamed , de Larramendi Idoia Ruiz , Ortiz‐Vitoriano Nagore 
Published: July 2024

AbstractThis perspective points out the potential of solid‐state Na‐air/O2 batteries for powering next‐generation storage devices, highlighting their high energy density, efficiency, and cost‐effectiveness. The challenges faced by Na‐air/O2 batteries, including liquid electrolyte instability, O2/O2− crossover, Na anode passivation, and dendritic growth are addressed. Strategies such as exploring solid‐state electrolytes (SSE), mitigating O2/O2− crossover, protecting the Na anode, and enhancing the solid electrolyte interphase (SEI) are discussed as potential solutions. Future challenges in advancing the technology are reviewed, emphasizing the need for addressing and understanding the fundamental mechanisms of (quasi)solid‐state Na‐air/O2 batteries (i.e., discharge product chemistry, dendritic growth, O2 crossover, the electrolyte properties, the stabilization of battery chemistry and Na+ transport). A roadmap outlining future directions is presented to overcome these challenges, with the goal of fully harnessing the potential of Na‐air/O2 batteries as a viable option for renewable energy and industrial‐scale commercialization.
Anionic Aggregates Induced Interphase Chemistry Regulation toward Wide‐Temperature Silicon‐Based Batteries
Authors: Mao Shulan , Zhang Jiahui , Mao Jiale , Shen Zeyu , Long Ziren , Zhang Shichao , Wu Qian , Cheng Hao , Lu Yingying 
Published: July 2024

AbstractSilicon nanoparticles (SiNPs) show great promise as high‐capacity anodes owing to their ability to mitigate mechanical failure. However, the substantial surface area of SiNPs triggers interfacial side reactions and solid electrolyte interphase (SEI) permeation during volume fluctuations. The slow kinetics at low temperatures and the degradation of SEI at high temperatures further hinder the practical application of SiNPs in real‐world environments. Here, these challenges are addressed by manipulating the solvation structure through molecular space hindrance. The electrolyte enables anions to aggregate in the outer Helmholtz layer under an electric field, leading to rapid desolvation capabilities and the formation of anion‐derived SEI. The resulting double‐layer SEI, where inorganic nano‐clusters are uniformly dispersed in the amorphous structure, completely encapsulates the particles in the first cycle. The ultra‐high modulus of this structure can withstand stress accumulation, preventing electrolyte penetration during repeated expansion and contraction. As a result, SiNPs‐based batteries demonstrate exceptional electrochemical performance across a wide temperature range from −20 to 60 °C. Moreover, the assembled 80 mAh SiNPs/LiFePO4 pouch cells maintain a cycling retention of 85.6% after 150 cycles, marking a significant step forward in the practical application of silicon‐based batteries.
Mechanism and Origins of Nucleophile‐Controlled Regioselectivity of Palladium‐Catalyzed Allylic C−H Amination of 1,4‐Dienes: A Computational Study
Authors: Zhang Mengyao , Wang Shiyu , Wu Hongli , Huang Genping 
Published: July 2024

AbstractDensity functional theory calculations have been conducted to investigate the palladium‐catalyzed allylic C−H amination of 1,4‐dienes with commonly available amines. The computations indicate that the reaction begins with the allylic C−H bond cleavage through the concerted proton and two‐electron transfer process to forge the η3‐allyl Pd(II) species. The ensuing C−N bond formation was found to be highly dependent on the basicity of the nucleophile, enabling the regioselectivity switch upon change of the nucleophile. With the weakly basic aromatic amine, the reaction occurs through the hydrogen‐bonding enabled inner‐sphere nucleophilic attack pathway. The distance between the reacting carbon atom and the terminal carbon atom is responsible for the Z/E‐selectivity. The regioselectivity is primarily due to steric repulsion between the allyl group and the ligand. On the other hand, the outer‐sphere nucleophilic attack pathway is favored for the reaction with the more basic aliphatic cyclic amine. The change of the coordinating mode of the allylic moiety was found to play a crucial role in determining the regioselectivity.
Flexible, transparent, and durable slippery liquid‐infused porous surface achieved by void‐centered PVDF‐co‐HFP membrane for self‐cleaning antifog coating
Authors: Tran Gia Huy , Nguyen Quang Binh , Bui Nu Ngoc Diem , Nguyen Van Hiep , Dinh Duc Anh , Van Le Thang , Hung Nguyen Dinh , La Thi Thai Ha , Bui Van‐Tien 
Published: July 2024

AbstractBioinspired smart surfaces, such as slippery liquid‐infused porous surfaces (SLIPS), have garnered significant attention due to their efficacy in self‐cleaning, antifouling, and antibacterial applications. Despite their advantages, SLIPS exhibit limitations such as compromised transparency, insufficient stability, and limited slippery performance, which have hindered their widespread practical use. To address these challenges, this article proposes a rational design utilizing a void‐centered poly(vinylidene fluoride‐co‐hexafluoropropylene) (PVDF) membrane for slippery liquid‐infused porous surfaces with exceptional flexibility, transparency, durability, and superior slippery performance. These advancements promise to enhance high‐performance, self‐cleaning, and antifogging coatings. The membranes, featuring large‐area, thickness‐customizable void‐centered PVDF, are fabricated through a two‐step process involving phase separation and selective etching. The utilization of PVDF polymer, which has a refractive index similar to that of silicon‐based lubricant oil, enhances transparency, while macrovoids positioned at the membrane's center, acting as oil reservoirs, improve the stability and performance of the SLIPS surfaces. Experimental findings demonstrate remarkable transparency of up to 93% in the visible light range and a lubricant oil uptake of 2.32 at a porosity of 70%. Moreover, the developed SLIPS exhibit outstanding durability, maintaining slippery performance with sliding angles of <10° following exposure to either 400 consecutive droplets or aging for up to 40 days. This study significantly contributes to the development of future SLIPS, particularly for applications such as antifogging coatings on vehicle glass and solar panels, and self‐cleaning surfaces.
Rifaximin and alternative agents in the management of irritable bowel syndrome: A comprehensive review
Authors: Deljavan Ghodrati Aylin , Comoglu Tansel 
Published: July 2024

AbstractRifaximin, a broad‐spectrum antibiotic, boasts a unique chemical composition and pharmacokinetic profile, rendering it highly effective in treating irritable bowel syndrome (IBS). Its minimal systemic absorption confines its impact to the gastrointestinal (GI) tract, where it yields significant therapeutic benefits. This review examines rifaximin's physico‐chemical attributes and its role in managing IBS symptoms. Its molecular structure facilitates intestinal lumen retention postoral administration, minimizing systemic exposure and adverse effects. This targeted action is crucial in addressing the gut microbiota's role in IBS pathophysiology. By modifying microbial populations and their metabolite production, rifaximin mitigates symptoms like bloating, irregular bowel habits, and abdominal pain associated with IBS. It achieves this by reducing pathogenic bacteria and altering bacterial metabolism, enhancing mucosal and immune function. Clinical trials affirm rifaximin's superiority over placebo and conventional therapies in alleviating overall IBS symptoms and addressing small intestine bacterial overgrowth (SIBO). Despite its promising efficacy and sustained symptom relief, further research is essential to optimize long‐term effectiveness and dosing regimens. Rifaximin stands as a vital treatment option for IBS due to its distinctive properties and clinical utility; yet, ongoing investigation is imperative for maximizing its therapeutic benefits.
Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis
Authors: Thomas Bethan L. , Montero‐Melendez Trinidad , Oggero Silvia , Kaneva Magdalena K. , Chambers David , Pinto Andreia L. , Nerviani Alessandra , Lucchesi Davide , Austin‐Williams Shani , Hussain Mohammed T. , Pitzalis Costantino , Allen Benjamin , Malcangio Marzia , Dell'Accio Francesco , Norling Lucy V. , Perretti Mauro 
Published: July 2024

ObjectiveThis study was undertaken to establish the potential therapeutic profile of neutrophil‐derived extracellular vesicles (EVs) in experimental inflammatory arthritis and associate pharmacological activity with specific EV components, focusing on microRNAs.MethodsNeutrophil EVs were administered intra‐articularly through a prophylactic or therapeutic protocol to male C57BL/6 mice undergoing serum‐transfer–induced inflammatory arthritis. Transcriptomic analysis of knees was performed on joints following EV administration, naive and arthritic mice (untreated; n = 4/group) and EV‐treated diseased mice (intra‐articular administration) with contralateral (vehicle‐treated; n = 8/group). Comparison of healthy donor and patients with rheumatoid arthritis (RA) neutrophil EVs was performed.ResultsEVs afforded cartilage protection with an increase in collagen‐II and reduced collagen‐X expression within the joint. To gain mechanistic insights, RNA sequencing of the arthritic joints was conducted. A total of 5,231 genes were differentially expressed (P < 0.05), with 257 unique to EV treatment. EVs affected key regenerative pathways involved in joint development, including Wnt and Notch signaling. This wealth of genomic alteration prompted to identify microRNAs in EVs, 10 of which are associated with RA. As a proof of concept, we focused on miR‐455‐3p, which was detected in both healthy donor and RA EVs. EV addition to chondrocyte cultures elevated miR‐455‐3p and exerted anticatabolic effects upon interleukin‐1β stimulation; these effects were blocked by actinomycin or miR‐455‐3p antagomir.ConclusionNeutrophils from patients with RA yielded EVs with composition, efficacy, and miR‐455‐3p content similar to those of healthy volunteers, suggesting that neutrophil EVs could be developed as an autologous treatment to protect and repair joint tissue of patients affected by inflammatory arthritides.image
The critical role of procurement in the emergence of circular business models: Insights from multiple cases of Vietnamese manufacturers
Authors: Tanveer Umair , Hoang Thinh Gia , Truong Huy Quang , Ishaq Shamaila , Gong Yu (Jack) 
Published: July 2024

AbstractWhile recent literature acknowledges the role of procurement in circular business models (CBM), a comprehensive exploration of its potential contribution remains scarce. This study delves into the under‐explored role of procurement in advancing CBMs within organizations. Employing a multiple case research design focused on four Vietnamese manufacturers, the research unveils procurement's distinctive contributions to CBM implementation. Emphasis is placed on supporting recyclability, reusability, waste reduction, and ethical standards aligned with competitive strategies. The study introduces a circular procurement framework, demonstrating its potential to drive CBM adoption. Theoretical contributions involve applying CE and CBM theories to procurement, identifying its role in CBM organization, uncovering barriers, and linking them to organizational context and financial considerations. In terms of practical implications, the research provides managerial guidance, emphasizing the pivotal link between procurement and CBM success, offering actionable insights for effectively navigating challenges, and fostering a culture of sustainable circularity within manufacturing businesses.
Binary Catalytic Hydrogen/Deuterium Exchange of Free α‐Amino Acids and Derivatives
Authors: Xiao Guorong , Sun Hong , Jiang Gege , Liu Ying , Song Gaohan , Kong Duanyang 
Published: July 2024

AbstractThe increasing demand for deuterium‐labeled amino acids and derivatives has heightened interest in direct hydrogen/deuterium exchange reactions of free amino acids. Existing methods, including biocatalysis and metal catalysis, typically require expensive deuterium sources or excessive use of deuterium reagents and often struggle with site selectivity. In contrast, this binary catalysis system, employing benzaldehyde and Cs2CO3 in the presence of inexpensive D2O with minimal stoichiometric quantities, facilitates efficient hydrogen/deuterium exchange at the α‐position of amino acids without the need for protecting groups in the polar aprotic solvent DMSO. The process is highly compatible with most natural and non‐natural α‐amino acids and derivatives, even those with potentially reactive functionalities. This advancement not only addresses the cost and efficiency concerns of existing methods but also significantly broadens the applicability and precision of deuterium labeling in biochemical research.
Generation of biosurfactants by P. aeruginosa gi |KP163922| on waste engine oil in a free and immobilized cells system
Authors: Jujaru Mohan , Pradhan Kajol , Gaur Shailee , Jain Amit , Kumar Sushil 
Published: July 2024

AbstractThis study investigated biosurfactant production by the bacterial strain of P. aeruginosa gi |KP 163922| for a free and immobilized cells system using waste engine oil (WEO) as a substrate. The polyurethane foam (PUF) cubes (1 cm × 1 cm × 1 cm) were used as carriers for the immobilization. The batch experiments were performed in Erlenmeyer flasks and monitored at every 24‐h interval for both cell systems. The microbial population was counted using the plate count method, and the hydrocarbon degradation percentage was calculated to evaluate the bacterial activity. Surface tension was measured at regular intervals to ensure the presence of biosurfactants. The maximum reduction was 37 and 35 mN/m in a free and immobilized cells system. Immobilization of cells using PUF was found to be efficient in supporting bacterial growth, and after 48 h of incubation, the growth was 2.5 (±0.58) × 1011 CFU/mL. The chemical characterization using Fourier transform infrared (FTIR) spectroscopy confirmed the obtained product as rhamnolipid. Crude biosurfactant yield was found to be maximum in the case of the immobilized system, which was approximately 18 g/L. Scanning electron micrographs (SEM) of the used PUF cubes showed the strong adherence of biofilm to the cube surface and the potential of its reuse in multiple cycles. Gas chromatography–mass spectrometry (GC–MS) analysis confirms that the immobilized strain of P. aeruginosa exhibited superior biodegradation capabilities compared to free cells. Specifically, it was capable of reducing the concentration of polyaromatic hydrocarbons and converting more significant aliphatic compounds into metabolic byproducts such as alkanes, alkenes, cycloalkanes, and carbonyl groups.