bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and retention rate of rufinamide in 300 patients: A single pediatric epilepsy center experience
Authors: Thome‐Souza Sigride , Kadish Navah E. , Ramgopal Sriram , Sánchez Fernández Iván , Bergin Ann M. , Bolton Jeffrey , Harini Chellamani , Libenson Mark , Olson Heather , Peters Jurriaan , Poduri Annapurna , Rotenberg Alexander , Takeoka Masanori , Kothare Sanjeev V. , Kapur Kush , Bourgeois Blaise F. D. , Loddenkemper Tobias 
Published: July 2014

SummaryObjectiveReports of studies evaluating rufinamide as an add‐on therapy in children and adolescents with refractory epilepsy are restricted to a few publications. Prospective multicenter studies including children and adults have yielded important information about several types of epilepsies and syndromes. We evaluated the use of rufinamide in a single pediatric center with a large cohort and long‐term follow‐up period.MethodsWe retrospectively included patients taking rufinamide from November 2008 to March 2013. Response was defined by a seizure reduction of ≥50% compared to baseline.ResultsThree hundred patients with a median age of 9.1 years (range 0.4–29.6 years) were reviewed. Median follow‐up was 9 months (range 1–37 months). Epilepsy etiology was classified as genetic (23.7%), structural/metabolic (41%), and unknown cause (35.3%). Overall, rufinamide treatment led to a median seizure frequency reduction of 59.2% from responders to baseline. Seizure reduction was greater in patients with genetic etiology compared to structural/metabolic (66.2% vs. 45.5% responders, p = 0.005). Rufinamide was discontinued in 110 (36.7%) of 300 patients: 63 (21%) due to unsatisfactory response, 47 (15.7%) due to side effects, and in 18 (6%) of those due to both. Most common adverse effects were sleepiness, vomiting, mood changes, nausea, and loss of appetite. Median time to loss of efficacy was 11.6 months (range 3–28 months).SignificanceRufinamide provides satisfactory seizure reduction as an adjunctive treatment in refractory epilepsy. Results need to be interpreted in the setting of data acquisition, including inherent biases of retrospective studies. Patients with a known genetic etiology may have better responses than patients with structural/metabolic etiology.A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.
Coexistence effect of UVA absorbers to increase their solubility and stability of supersaturation
Authors: Endo M. , Mukawa T. , Sato N. , Maezawa D. , Ohtsu Y. , Kuroda A. , Wakabayashi M. , Asakura K. 
Published: July 2014

SynopsisObjectiveSunscreens containing UVA absorbers in high concentrations are expected to be developed, since recent studies have suggested the possibility of involvement of UVA ray in skin cancer and early skin aging. Solubility and stability of supersaturation of UVA absorbers in UVB absorber were determined in the absence and the presence of cosmetic oil. Coexistence effect of UVA absorbers was analyzed to dissolve them in high concentrations.MethodsTwo UVA absorbers, diethylamino hydroxybenzoyl hexyl benzoate (DHHB) and butyl methoxydibenzoylmethane (BMDM), a UVB absorber, 2‐ethylhexyl methoxycinnamate (EHMC), and a cosmetic oil, 2‐ethylhexyl ester of oligomer of hydroxystearic acid (EH‐O‐HSA), were used. Their solutions were prepared at 80°C and cooled to 5°C. The solid DHHB and/or BMDM were added to it, and the time evolution of concentrations of the UVA absorbers in the solution phase was monitored.ResultsAt the saturation in the absence of EH‐O‐HSA at 5°C, weight ratio of DHHB and BMDM to EHMC was 0.39/1.00 and 0.22/1.00, respectively. Addition of EH‐O‐HSA slightly changed the solubility of DHHB and BMDM. When the weight ratio of EH‐O‐HSA to EHMC was 0.20/1.00, weight ratio of DHHB and BMDM to EHMC was 0.35/1.00 and 0.25/1.00, respectively at the saturation at 5°C. In the presence of EH‐O‐HSA, a strong coexistence effect of DHHB and BMDM was found on their solubility. A thermodynamically stable saturated solution at 5°C having the composition that DHHB: BMDM: EHMC: EH‐O‐HSA = 0.47: 0.46: 1.00: 0.20 was obtained by the simultaneous addition of solid DHHB and BMDM into the initial solution.ConclusionThe solution type composite having the highest concentrations of DHHB and BMDM prepared in this study exhibited critical wavelength at 368 nm that was just below the border for sunscreens being qualified as ‘Broad Spectrum’ protection under the new rule launched by US FDA.
From experimental design to functional gene networks: DNA microarray contribution to skin ageing research
Authors: Benech P. D. , Patatian A. 
Published: July 2014

SynopsisThere is no doubt that the DNA microarray‐based technology contributed to increase our knowledge of a wide range of processes. However, integrating genes into functional networks, rather than terms describing generic characteristics, remains an important challenge. The highly context‐dependent function of a given gene and feedback mechanisms complexify greatly the interpretation of the data. Moreover, it is difficult to determine whether changes in gene expression are the result or the cause of pathologies or physiological events. In both cases, the difficulty relies on the involvement of processes that, at an early stage, can be protective and later on, deleterious because of their runaway. Each individual cell has its own transcription profile that determines its behaviour and its relationships with its neighbours. This is particularly true when a mechanism such as cell cycle is concerned. Another issue concerns the analyses from samples of different donors. Whereas the statistical tools lead to determine common features among groups, they tend to smooth the overall data and consequently, the selected values represent the ‘tip of the iceberg’. There is a significant overlap in the set of genes identified in the different studies on skin ageing processes described in the present review. The reason of this overlap is because most of these genes belong to the basic machinery controlling cell growth and arrest. To get a more full picture of these processes, a hard work has still to be done to determine the precise mechanisms conferring the cell type specificity of ageing. Integrative biology applied to the huge amount of existing microarray data should fulfil gaps, through the characterization of additional actors accounting for the activation of specific signalling pathways at crossing points. Furthermore, computational tools have to be developed taking into account that expression values among similar groups may not vary ‘by chance’ but may reflect, along with other subtle changes, specific features of one given donor. Through a better stratification, these tools will allow to recover genes from the ‘bottom of the iceberg’. Identifying these genes should contribute to understand how skin ages among individuals, thus paving the way for personalized skin care.
Orthodontic treatment for a patient with hereditary angiodema: a case report
Authors: Waldon Kate , Barber Sophy Kathleen , Spencer Richard James 
Published: July 2014

BackgroundHereditary angiodema (HAE), also known as C1 esterase inhibitor deficiency, causes sufferers to experience episodic subcutaneous and submucosal oedema. These episodes can be triggered by dental treatment and manifest as life‐threatening oedematous swelling in the head and neck region.Case ReportThis case report reviews an adolescent with hereditary angiodema whose malocclusion required orthodontic intervention. Due to her complex and unpredictable reaction to dental treatment, various options were explored before determining the appropriate care pathway for this patient. Trial placement of a sectional fixed appliance tested the tissue reaction prior to comprehensive treatment including extractions and fixed orthodontic appliances.ConclusionThis report demonstrates successful interdisciplinary management facilitating orthodontic care in a patient with HAE.
Direct long‐distance dispersal shapes a New World amphitropical disjunction in the dispersal‐limited dung moss Tetraplodon (Bryopsida: Splachnaceae)
Authors: Lewis Lily R. , Rozzi Ricardo , Goffinet Bernard 
Published: July 2014

AbstractAimMany intercontinental disjunctions, especially among spore‐producing plants, are shaped by long‐distance dispersal (LDD) via wind currents. Amphitropical disjunctions are most commonly explained through LDD, but other vectors and dispersal scenarios must also be considered. To interpret the New World amphitropical disjunction in the dung‐moss genus Tetraplodon, we compared stepwise migration along the Andes, direct LDD and ancient vicariance.LocationGlobal, specifically high‐latitude and high‐elevation localities, with a focus on the New World.MethodsPhylogenetic relationships were inferred from four loci sampled from 124 populations representing the global range of Tetraplodon, and analysed using maximum‐likelihood and Bayesian optimality criteria, with divergence dates estimated in beast.ResultsThe monophyletic T. mnioides complex diversified between the early Miocene and early‐to‐mid Pliocene into three well‐supported clades, each with a unique geographical distribution: Laurasian, primarily high‐elevation tropical, and amphitropical. Populations from southernmost South American were reconstructed as a monophyletic lineage that diverged from high‐latitude Northern Hemisphere populations around 8.63 Ma [95% highest posterior density (HPD) 3.07–10.11 Ma].Main conclusionsDirect LDD has resulted in the American amphitropical disjunction in Tetraplodon. A lack of modern or historical wind connectivity between polar regions and the poor resistance of Tetraplodon spores to the conditions associated with wind‐dispersal suggest that bird‐mediated LDD provides the best explanation for the establishment of amphitropicality.
Positive Response to Cardiac Resynchronization Therapy Reduces Arrhythmic Events After Elective Generator Change in Patients with Primary Prevention CRT‐D
Authors: SEBAG FREDERIC A. , LELLOUCHE NICOLAS , CHEN ZHONG , TRITAR AMINE , O'NEILL MARK D. , GILL JASWINDER , WRIGHT MATTHEW , LECLERCQ CHRISTOPHE , RINALDI CHRISTOPHER A. 
Published: July 2014

Arrhythmic Outcome After CRT‐D Device ReplacementIntroductionCardiac resynchronization therapy (CRT) and implantable cardioverter‐defibrillators (ICD) are effective therapies for heart failure (HF) patients with cardiac dyssynchrony. Patients receiving primary prevention CRT‐defibrillator that positively remodel might no longer qualify for ICD indication due to CRT‐induced left ventricular ejection fraction (LVEF) improvement. We aimed to evaluate the outcome of CRT‐D patients at the time of device replacement (DR).Methods and ResultsPatients undergoing primary prevention CRT‐D DR were prospectively included from November 2007 to March 2011 in 2 centers. CRT response was as defined as ≥1 NYHA class improvement and an increase in LVEF ≥10%. Before DR, all patients underwent echocardiography and device interrogation. Patients without theoretical ongoing ICD indication (TOII) at DR were defined as those with LVEF ≥40% without appropriate ICD therapy (appropriate therapy) during the first ICD service‐life. A total of 107 consecutive patients were enrolled. Sixty‐one patients (57%) were considered CRT responders after the index procedure. At the time of DR (56.4 ± 14.4 months from initial implant), 87% of CRT responders were free of appropriate therapy, compared with 70% of CRT nonresponders (P = 0.02). Thirty‐nine patients (37%) did not meet the criteria for TOII. During follow‐up (mean 26.4 ± 14.4 months after DR), 37 patients (95%) without TOII were free of appropriate therapy versus 49 of 68 patients (72%) with ongoing TOII (P = 0.007). By multivariable analysis, the only independent predictor of appropriate therapy after DR was TOII (hazard ratio = 6.43; P = 0.01).ConclusionAbsence of theoretical ICD indication occurs in more than one‐third of CRT‐D patients undergoing DR. In addition, appropriate therapy rate is relatively low (2.2% per year) in this subgroup of patients.
Pulmonary Vein Isolation with a New Multipolar Irrigated Radiofrequency Ablation Catheter (nMARQ™): Feasibility, Acute and Short‐Term Efficacy, Safety, and Impact on Postablation Silent Cerebral Ischemia
Authors: SCAGLIONE MARCO , CAPONI DOMENICO , ANSELMINO MATTEO , CLEMENTE FRANCESCA DI , BLANDINO ALESSANDRO , FERRARIS FEDERICO , DONNA PAOLO DI , EBRILLE ELISA , HALIMI FRANCK , LECLERCQ JEAN F. , IUNCO COSTANZA , VAUDAGNA CARLOEUGENIO , CESARANI FEDERICO , GAITA FIORENZO 
Published: July 2014

PVI with nMARQ™BackgroundSimultaneous multipolar ablation catheters have been proposed to simplify pulmonary vein isolation (PVI) in paroxysmal atrial fibrillation (AF). Recently, a new multipolar irrigated radiofrequency (RF) ablation catheter (nMARQ™, Biosense Webster Inc., Diamond Bar, CA, USA) combining both 3‐dimensional electroanatomic mapping and multipolar open‐irrigated ablation capability has been developed. Aim of our study was to assess feasibility, acute and short‐term success and safety of PVI by the use of this new technology with particular regard to the incidence of postablation silent cerebral ischemia (SCI).Methods and ResultsTwenty‐five patients (76% males; age 57 ± 13 years) with paroxysmal AF underwent PVI using the nMARQ™ catheter. PVI, confirmed by Lasso catheter mapping, was achieved in 100 out of 102 pulmonary veins (98%) identified, and final PVI was obtained in 24 out of 25 (96%) patients. The overall concordance between Lasso and nMARQ™ signals in demonstrating PVI was 78%. No major procedural complications occurred and no patient suffered SCI, on the basis of cerebral magnetic resonance imaging performed before and after the procedure. Following a 6‐month follow‐up, 17/25 (68%) patients remained free from AF without antiarrhythmic drugs.ConclusionsIn our preliminary experience, PVI with nMARQ™ catheter appears to be feasible and safe, without incidence of SCI. Long‐term clinical efficacy has to be evaluated in further studies.
IgG sera levels against a subset of periodontopathogens and severity of disease in aggressive periodontitis patients: a cross‐sectional study of selected pocket sites
Authors: Saraiva Luciana , Rebeis Estela S. , Martins Eder de S. , Sekiguchi Ricardo T. , Ando‐Suguimoto Ellen S. , Mafra Carlos Eduardo S. , Holzhausen Marinella , Romito Giuseppe A. , Mayer Marcia P. A. 
Published: July 2014

AbstractAimsTo evaluate the association among serum immunoglobulin G (IgG) responses to Aggregatibacter actinomycetemcomitans (Aa) serotypes a, b and c, Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf) and clinical parameters in Aggressive Periodontitis (AP) subjects. Associations between periodontal pathogens and clinical and immunological parameters were also evaluated.MethodsThirty‐eight subjects diagnosed with generalized AP (GAP) and localized AP (LAP) were included. Ten healthy controls were also evaluated. Clinical parameters were assessed and percentages of subgingival levels of Aa, Pg and Tf (beyond bacterial load), were determined by quantitative real‐time polymerase chain reaction. Serum IgG antibody levels against Aa, Pg and Tf were evaluated by enzyme‐linked immunosorbent assay.ResultsPercentages of Aa, Pg and Tf were significantly higher in AP than in controls. The response to Aa serotype c was higher in LAP subjects than in controls. There were no differences in microbial composition or antibodies responses between GAP and LAP, except for IgG response to Tf. Pg levels were correlated with probing depth (PD), BoP and CAL in GAP but not in LAP subjects. Tf levels correlated with PD and CAL in GAP subjects. In GAP, the infection levels of Aa and Pg correlated with the corresponding IgG levels to Aa serotype c and Pg.ConclusionGiven the evidences that IgG response in AP patients correlated with bacterial infection level in GAP, but not in LAP, and that LAP patients lack a response to Tf, despite harbouring this species, our data suggest a difference in host immune defence between these two forms of aggressive periodontitis.
Autoantibodies against TIF‐1‐γ and CADM‐140 in Spanish patients with clinically amyopathic dermatomyositis (CADM): clinical significance and diagnostic utility
Authors: Cuesta‐Mateos C. , Colom‐Fernández B. , Portero‐Sainz I. , Tejedor R. , García‐García C. , Concha‐Garzón M.J. , De las Heras‐Alonso M.E. , Martínez M.A. , Juarez C. , Muñoz‐Calleja C. 
Published: July 2014

AbstractBackgroundPatients with clinically amyopathic dermatomyositis (CADM) appear to be at risk for developing cancer and interstitial lung diseases, but population data to confirm this hypothesis are limited. Moreover, CADM presents cutaneous and histological findings that may overlap with subacute cutaneous lupus erythematosus (SCLE).ObjectivesTo determine the association between myositis‐specific autoantibodies, myositis‐associated autoantibodies and CADM in Spanish patients. In addition, to study the usefulness of these autoantibodies in the differential diagnosis between CADM and SCLE.MethodsSerum samples were tested for myositis‐specific autoantibodies and myositis‐associated autoantibodies through immunoprecipitation and other standardized methods.ResultsAnti‐CADM‐p140 and anti‐p155 antibodies were the only myositis‐specific autoantibodies found and were associated with interstitial lung diseases and cancer respectively. No myositis‐associated autoantibodies were found in CADM. Moreover, clinical subsets and proportions seemed to differ from Asian cohorts, where anti‐CADM‐p140 is considered a CADM hallmark antibody and a risk factor for the development of interstitial lung disease. Interestingly, anti‐SSA was highly associated with SCLE, whereas no myositis‐specific autoantibodies were found in this entity.Limitations of the studyAssociation between CADM and myositis‐specific autoantibodies and differences between CADM and SCLE were tested on a relatively small cohort of patients.ConclusionThere is an association between cancer‐associated myositis and interstitial lung diseases and their hallmark autoantibodies in our cohort. In addition, the combined determination of myositis‐specific autoantibodies and SSA autoantibodies may help to accurately discriminate SCLE from CADM.
Beyond Energy
Authors: Fichter Klaus , Hintemann Ralph 
Published: July 2014

SummaryThis article is based on the first study worldwide to analyze materials present in the equipment of data centers. The study develops a methodology that allows the calculation of the number of data centers of the various size classes and their average equipment with information technology (IT) components and infrastructure elements, such as air‐conditioning systems and power supplies. This enables detailed statements to be made on the materials present in the equipment of approximately 53,000 data centers in Germany. In 2008, the total amount of materials in the equipment of data centers in Germany was 110,300 tonnes (t). IT equipment (servers, storage equipment, and network) accounted for 37,500 t (34%), racks and containments for 30,700 t (28%), cooling and air‐conditioning systems for 12,000 t (11%), and the power infrastructure for 30,000 t (27%). A comprehensive analysis of the type of materials being used yielded the following values: Approximately 58,400 t of iron, 18,600 t of copper, 11,600 t of circuit boards, 11,100 t of plastics, 7,400 t of aluminum, and 6,500 t of miscellaneous materials were present in German data centers. The electronic material contained 1.8 t of gold, 7.5 t of silver, and 0.8 t of palladium. Because it can be assumed that prices for precious metals, and also for bulk metals, will continue to rise, the recovery of raw materials from the IT devices of data centers is an interesting option. Additionally, the development of appropriate product design and recycling strategies for servers and storage units should be implemented.
Securing a Competitive Advantage through Industrial Symbiosis Development
Authors: Park Joo Young , Park Hung‐Suck 
Published: July 2014

SummaryHyosung Yongyeon PlantsPlant I: Operated since 1991Plant II: Operated since 1997Plant III: Built in 2009Organization type: Production facilities of Hyosung, a public companyHeadquarters: Seoul, Republic of KoreaIndustries: ChemicalPlant I: Polypropylene (PP)Plant II: TPA (purified terephthalic acid)Plant III: Optical TAC (cellulose triacetate) filmEmployees: 450Annual production:Plant I: 300,000 tonnes of PPPlant II: 420,000 tonnes of TPAPlant III: 50 million square meters (m2) of liquid crystal display (LCD) TAC film
Exfoliative cytology as a tool for monitoring pre‐malignant and malignant lesions based on combined stains and morphometry techniques
Authors: Gonzalez Segura Ignacio , Secchi Dante , Carrica Andres , Barello Rosario , Arbelo Dario , Burgos Adriana , Brunotto Mabel , Zarate Ana M. 
Published: July 2014

BackgroundPrevention and early diagnosis have the greatest potential for public health and are the most effective method in the long‐term to control oral cancer. The aim was to apply PAP staining together with AgNOR staining and morphometric analysis in oral exfoliative cytology, to determine the sensitivity and specificity of these methods in the detection of malignant changes for the purposes of both initial population monitoring and follow‐up.MethodsAgNOR, Papanicolau, and morphometric tests were conducted in samples of patients with oral cancer, oral potentially malignant disorders and controls (opposite side of lesions). Specificity and sensitivity values for each stain method and the curve under ROC area were estimated.ResultsThe diagnostic variables which allowed greatest accuracy in identifying malignancy relative to the healthy control were cluster (76.92%), satellite (75.64%), and total (90%). The diagnosis was seen to be associated with PAP and total AgNOR, total AgNOR and PAP, total AgNOR and satellites and clusters, and total AgNOR nuclear area/cytoplasmic area ratio.ConclusionsThe total number of AgNOR is a reliable marker for detecting neoplastic cells; this method increases sensitivity and specificity by decreasing the likelihood of false negatives or positives, as the accuracy obtained was 90%. It is also a low‐cost, non‐invasive, simple methodology that can be recommended to help the early detection of oral cancer and monitoring of patients with a first diagnosis of cancer.
INTRA‐DIALYTIC EXERCISE TRAINING: A PRAGMATIC APPROACH
Authors: Greenwood Sharlene A. , Naish Patrick , Clark Rachel , O'Connor Ellen , Pursey Victoria A. , Macdougall Iain C. , Mercer Thomas H. , Koufaki Pelagia 
Published: July 2014

SUMMARYThis continuing education paper outlines the skills and knowledge required to plan, implement and evaluate a pragmatic approach to intra‐dialytic exercise training.Aim: The aim of this continuing education article is to enable the nephrology multi‐disciplinary team (MDT) to plan, implement and evaluate the provision of intra‐dialytic exercise training for patients receiving haemodialysis therapy.LEARNING OUTCOMES: After reading this article the reader should be able to:

Appreciate the level of evidence base for the clinical effectiveness of renal exercise rehabilitation and locate credible sources of research and educational information
Understand and consider the need for appropriate evaluation and assessment outcomes as part of a renal rehabilitation plan
Understand the components of exercise programming and prescription as part of an integrated renal rehabilitation plan
Develop a sustainable longer term exercise and physical activity plan