bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of embryologist sufficiency and associated regional disparities in Japanese assisted reproduction facilities using nationwide survey data (IZANAMI project)
Authors: Shirasawa Hiromitsu , Yamada Mitsutoshi , Jwa Seung Chik , Kuroda Keiji , Harada Miyuki , Osuga Yutaka 
Published: July 2024

AbstractAimsThis study aims to comprehensively examine the employment and practices of embryologists in Japan's assisted reproductive technology (ART) laboratories, focusing on the impact of various factors such as ART cycle numbers, add‐ons, and regional differences. Additionally, it seeks to assess the extent to which Japanese ART facilities meet international minimum standards set by the American Society for Reproductive Medicine (ASRM).MethodsA survey was conducted from December 2021 to February 2022 among 621 ART facilities in Japan. The study categorized facilities into five ART cycle groups and compared the number of embryologists across these groups. It also examined the correlation between the number of embryologists, ART cycles, add‐ons, and regional differences. Data were analyzed using linear regression and multiple linear regression analyses.ResultsThe study's findings revealed a significant correlation between the total number of embryologists at each facility and the ART cycles. Notably, there were significant differences in the number of embryologists across all ART cycle categories. Of the 435 facilities, only 44.6% met the ASRM minimum embryologist staffing requirement. The regression analysis further highlighted the significance of ART cycles and preimplantation genetic testing for aneuploidies as factors. Moreover, the number of embryologists stationed at urban facilities was significantly higher than at nonurban facilities, indicating a potential regional disparity.ConclusionIn Japan, it was first found that more than 50% of ART facilities do not have sufficient embryologists in place relative to the number of ART cycles. Furthermore, the add‐ons and regional differences affect the placement of embryologists.
Place‐based tax incentives and minority employment: Evidence from the New Market Tax Credit Program
Authors: Rupasingha Anil , Marré Alexander , Feliciano Josemari 
Published: July 2024

AbstractIn this paper, we study the impact of the New Market Tax Credit (NMTC) program in the United States on overall jobs and jobs held by minority and rural populations within the 2010–2019 period using a dynamic event‐study analysis. We also investigate if the jobs that can be attributed to the program stayed in program recipient neighborhoods or whether those jobs were occupied by non‐residents. The results show that there is clear evidence that the program increased overall workplace jobs and workplace jobs held by White and minority populations in the program recipient tracts. We also see that a larger share of workplace jobs due to the program went to minorities compared to the job shares held by various racial and ethnic groups at the beginning of the investment period. The results further show that even though the NMTC program increased the number of jobs available in a program recipient tract, the individuals who live outside that tract are holding many of the jobs created. The results also suggest that the program had a negative impact on jobs held by residents in nonmetropolitan tracts.
Burnout, Engagement, and Resilience During the COVID‐19 Lockdown: Keys to a Model for Teachers' Self‐Efficacy
Authors: Rodríguez‐Hidalgo Antonio J. , Ruiz‐Córdoba Esther , Ortega‐Ruiz Rosario , Armada‐Crespo José M. , Hurtado‐Mellado Almudena , Dios Irene 
Published: July 2024

ABSTRACTBACKGROUNDSocial isolation measures by the COVID‐19 pandemic have impacted teaching work. In an “Emergency Remote Teaching” (ERT) context, it is relevant to investigate the factors that affect teachers' self‐efficacy.METHODSA total of 289 teachers from schools in southern Spain have participated in this study. They have been asked about their levels of burnout, engagement, and resilience. Comparisons were made by groups in accordance with sex, type of center they belonged to, school social context, and educational level in which the teacher taught. Using a Structural Equations Model, the multivariate relationships between the variables related to burnout, engagement, and resilience were described.RESULTSDuring the ERT, teachers' self‐efficacy was influenced by the 3 factors: burnout—exhaustion and cynicism—engagement, and resilience. During the ERT, the teachers in semi‐private and private centers showed greater self‐efficacy. In turn, the teachers in childhood and primary education showed a significantly higher level of work engagement than the teachers in compulsory and post‐compulsory secondary education.CONCLUSIONSThe results in relation to ERT are discussed in the context of the exceptionality and universal globality of the pandemic phenomenon and the complex self‐perception of the social value of the teaching function.
Fighting Racism Denial; Becoming a Mother‐Scholar‐Activist
Authors: Bonam Courtney M. 
Published: July 2024

AbstractUsing autoethnography and a Critical Race Theory framework, I recount how I experienced racism denial in my son's school district during 2019–2020 (his kindergarten year). To build this counternarrative, I analyzed multiple data sources (e.g., field notes, personal journal entries, public documents) and, across three chapters, describe my interactions with key school district gatekeepers while advocating for racial equity‐oriented school policies. These policies included: a school desegregation program (Chapter 1), a plan to incorporate critical race education into one school's curriculum (Chapter 2), and a district‐level endorsement of critical race and ethnic studies K‐12 curriculum in California schools (Chapter 3). In responding to this advocacy, the district professed surface‐level support for racial equity, but I saw this form of support as racism denial merely masquerading as support for racial equity. I explain why I interpreted the district's responses in this way, and how I experienced these responses from my perspective as a mixed Black mother, scholar, and activist. I end by reflecting on how these experiences forced me to integrate my mother‐scholar‐activist identities in uncomfortable and productive ways, and with recommendations for how psychological researchers and K‐12 schools can support racial equity.
Cytokine responses of CD4+ T cells and NKT cells to periodontitis‐associated bacteria in individuals with or without periodontitis
Authors: Danielsen Anne Katrine , Massarenti Laura , Minculescu Lia , Jensen Peter Østrup , Hansen Peter Riis , Holmstrup Palle , Damgaard Christian , Nielsen Claus Henrik 
Published: July 2024

AbstractAimPeriodontitis is an inflammatory disease driven by opportunistic bacteria including Porphyromonas gingivalis and Fusobacterium nucleatum, where T‐cell and NKT‐cell responses to these bacteria in patients with periodontitis grade B or C are not fully elucidated. The objective is to determine if exaggerated proinflammatory Th‐cell responses to periodontitis‐associated bacteria, but not commensal bacteria, is a characteristic of increased periodontitis grade.MethodsMononuclear cells from patients with periodontitis grade C (n = 26) or grade B (n = 33) and healthy controls (HCs; n = 26) were stimulated with P. gingivalis, F. nucleatum or the commensal bacteria, Staphylococcus epidermidis and Cutibacterium acnes. Cytokine production by different T‐cell populations and FOXP3‐expression by regulatory T cells were assessed by flow cytometry.ResultsCompared to HCs, grade C patients had decreased frequencies of interleukin (IL)‐10‐producing CD4+ T cells before stimulation (p = .02) and increased frequencies of IFN‐y‐producing CD4+ T cells after stimulation with P. gingivalis (p = .0019). Grade B patients had decreased frequencies of FOXP3+ CD4+ T cells before (p = .030) before and after stimulation with anti‐CD2/anti‐CD3/anti‐CD28‐loaded beads (p = .047), P. gingivalis (p = .013) and S. epidermidis (p = .018). Clinical attachment loss correlated with the frequencies of IFN‐y‐producing Th1 cells in P. gingivalis‐ and F. nucleatum‐stimulated cultures in grade B patients (p = .023 and p = .048, respectively) and with the frequencies of Th17 cells in P. gingivalis‐stimulated cultures (p = .0062) in grade C patients. Patients with periodontitis grade C or grade B showed lower frequencies of IL‐10‐producing NKT cells than HCs in unstimulated cultures (p = .0043 and p = .027 respectively).ConclusionsBoth periodontitis groups showed decreased frequencies of immunoregulatory T‐cell and NKT cell subsets at baseline. Clinical attachment loss correlated with P. gingivalis‐induced Th17‐responses in grade C patients and with Th1‐responses in grade B patients when cells were stimulated with P. gingivalis, supporting that dysregulated pro‐inflammatory T‐cell responses to periodontitis‐associated bacteria contribute to the pathogenesis of periodontitis.
Native vs. ribosome‐crosslinked collagen membranes for periodontal regeneration: A randomized clinical trial
Authors: Wang Yiwei , Xia Yiru , Qian Jielei , Xie Yufeng , Shu Rong , Lin Zhikai 
Published: July 2024

AbstractAimTo evaluate whether the ribosome‐crosslinked collagen membrane (RCCM) is non‐inferior to the natural collagen membrane (NCM) used in regeneration surgery in terms of clinical attachment level (CAL) gain at 6 months.MethodsEighty patients diagnosed as generalized periodontitis presenting with isolated infrabony defect (≥4 mm deep) were enrolled and randomized to receive regenerative surgery, either with NCM or RCCM, both combined with deproteinized bovine bone mineral (DBBM). CAL, pocket probing depth (PPD), and gingival recession (GR) were recorded at baseline, 3, and 6 months postoperatively. Periapical radiographs were taken at baseline, immediately, and 6 months after surgery. Early wound healing index (EHI) and patients' responses were recorded at 2 weeks postoperatively.ResultsAt 6 months post‐surgery, the mean CAL gain was 3.1 ± 1.5 mm in the NCM group and 2.9 ± 1.5 mm in the RCCM group, while the mean PPD was 4.3 ± 1.1 mm in the NCM group and 4.2 ± 1.0 mm in the RCCM group. Both groups demonstrated a statistically significant improvement from the baseline (p < .01). RCCM was non‐inferior to NCM concerning the primary outcome (CAL gain at 6 months). The GR at 6 months postoperatively was 1.3 ± 1.2 and 1.2 ± 1.1 mm, which showed no difference compared with baseline. At 6 months follow‐up, the radiographic linear bone fill (RLBF) was 6.5 ± 2.8 and 5.5 ± 2.6 mm (p > .05), while the bone fill percentage (BF%) was 102.3 ± 53.5% and 92.3 ± 40.1% (p > .05), in the NCM and RCCM groups, respectively. There was no significant difference in EHI and postoperative responses between two groups.ConclusionRCCM + DBBM resulted in no‐inferior clinical and radiographic outcomes to NCM + DBBM for the treatment of isolated infrabony defect in 6 months.
Liver injury in paraquat poisoning: A retrospective cohort study
Authors: Zhang Yan , Hou Linlin , Yuan Ding , Wu Jingtao , Wang Yibo , Yu Yanwu , Meng Cuicui , Yang Fang , Yan Hongyi , Du Yuqi , Zhu Huanzhou , Walline Joseph H. , Jiang Yong , Gao Yanxia , Li Yi 
Published: July 2024

AbstractBackground and AimsLiver injury is one of the common complications of paraquat (PQ) poisoning, but whether the degree of liver injury is related to patient prognosis is still controversial. This study aimed to investigate whether liver injury was a risk factor for death in PQ‐poisoned patients.MethodsWe conducted a retrospective cohort study of PQ‐poisoned patients from the past 10 years (2011–2020) from a large tertiary academic medical centre in China. PQ‐poisoned patients were divided into a normal liver function group (n = 580) and a liver injury group (n = 60). Propensity score matching (PSM) analysis was then performed.ResultsA total of 640 patients with PQ poisoning were included in this study. To reduce the impact of bias, dose of PQ, urinary PQ concentration and time from poisoning to hospital admission were matched between the two groups. A 3:1 PSM analysis was performed, ultimately including 240 patients. Compared with the normal liver function group, patients in the liver injury group were older, had a higher R value ([ALT/ULN]/[ALP/ULN]) (p < .001) and had a higher mortality rate. Cox regression analysis showed that there was no significant association between alanine aminotransferase, alkaline phosphatase, total bilirubin levels and hazard of death, but age, PQ dose, creatine kinase isoenzyme, creatine kinase, white blood cell count, neutrophil percentage and lymphocyte percentage were associated with mortality in patients with PQ poisoning.ConclusionsThe occurrence of liver injury within 48 h after PQ poisoning was a risk factor for mortality, and such liver injury was likely of a hepatocellular nature. Age, PQ dose, creatine kinase isoenzyme and white blood cell count were positively correlated with mortality, while creatine kinase, percentage of neutrophils and lymphocytes were inversely correlated.
A facilitator's reflection on the democratizing potential of emancipatory practice development
Authors: Peet Jacqueline , Theobald Karen A. , Douglas Clint 
Published: July 2024

AbstractEmancipatory practice development (ePD) is a practitioner‐led research methodology which enables workplace transformation. Underpinned by the critical paradigm, ePD works through facilitation and workplace learning, with people in their local context on practice issues that are significant to them. Its purpose is to embed safe, person‐centred learning cultures which transform individuals and workplaces. In this article, we critically reflect on a year‐long ePD study in an acute care hospital ward. We explore the challenges of practice change within systems, building collective strength with frontline collaborations and leadership to sustain new learning cultures. Our work advances practice development dialogue through working closely with the underpinning theories. Our critique analyses how ePD can enact and sustain change within a complex system. We argue that ePD works to strengthen safety cultures by challenging antidemocratic practices through communicative action. By opening communicative spaces, ePD enables staff to collectively deliberate and reach consensus. Their raised awareness supports staff to resist ways of working which conspire against safe patient care. Sustainability of practice change is fostered by the co‐operative democracies created within the frontline team and meso level enablement. We conclude that the democratising potential of ePDt generates staff agency at the frontline.
Bacillus suppresses nitrogen efficiency of soybean–rhizobium symbiosis through regulation of nitrogen‐related transcriptional and microbial patterns
Authors: Wang Tianqi , Chen Qianqian , Liang Quan , Zhao Qian , Lu Xing , Tian Jihui , Guan Zidi , Liu Chang , Li Jifu , Zhou Ming , Tian Jiang , Liang Cuiyue 
Published: July 2024

AbstractThe regulation of legume‐rhizobia symbiosis by microorganisms has obtained considerable interest in recent research, particularly in the common rhizobacteria Bacillus. However, few studies have provided detailed explanations regarding the regulatory mechanisms involved. Here, we investigated the effects of Bacillus (Bac.B) on Bradyrhizobium–soybean (Glycine max) symbiosis and elucidated the underlying ecological mechanisms. We found that two Bradyrhizobium strains (i.e. Bra.Q2 and Bra.D) isolated from nodules significantly promoted nitrogen (N) efficiency of soybean via facilitating nodule formation, thereby enhanced plant growth and yield. However, the intrusion of Bac.B caused a reverse shift in the synergistic efficiency of N2 fixation in the soybean–Bradyrhizobium symbiosis. Biofilm formation and naringenin may be importantin suppression of Bra.Q2 growth regulated by Bac.B. In addition, transcriptome and microbiome analyses revealed that Bra.Q2 and Bac.B might interact to regulateN transport and assimilation, thus influence the bacterial composition related to plant N nutrition in nodules. Also, the metabolisms of secondary metabolites and hormones associated with plant–microbe interaction and growth regulation were modulated by Bra.Q2 and Bac.B coinoculation. Collectively, we demonstrate that Bacillus negatively affects Bradyrhizobium–soybean symbiosis and modulate microbial interactions in the nodule. Our findings highlight a novel Bacillus‐based regulation to improve N efficiency and sustainable agricultural development.
A molecular module connects abscisic acid with auxin signals to facilitate seasonal wood formation in Populus
Authors: Guo Xulei , Li Jian , Li Meng , Zhou Bo , Zheng Shuai , Li Laigeng 
Published: July 2024

AbstractPerennial trees have a recurring annual cycle of wood formation in response to environmental fluctuations. However, the precise molecular mechanisms that regulate the seasonal formation of wood remain poorly understood. Our prior study indicates that VCM1 and VCM2 play a vital role in regulating the activity of the vascular cambium by controlling the auxin homoeostasis of the cambium zone in Populus. This study indicates that abscisic acid (ABA) affects the expression of VCM1 and VCM2, which display seasonal fluctuations in relation to photoperiod changes. ABA‐responsive transcription factors AREB4 and AREB13, which are predominantly expressed in stem secondary vascular tissue, bind to VCM1 and VCM2 promoters to induce their expression. Seasonal changes in the photoperiod affect the ABA amount, which is linked to auxin‐regulated cambium activity via the functions of VCM1 and VCM2. Thus, the study reveals that AREB4/AREB13‐VCM1/VCM2‐PIN5b acts as a molecular module connecting ABA and auxin signals to control vascular cambium activity in seasonal wood formation.
Contemporary Concise Review 2023: Advances in lung cancer and interventional pulmonology
Authors: Leong Tracy L. , Steinfort Daniel P. 
Published: July 2024

Summary of Key Points
Eligibility criteria for lung cancer screening increasingly need to consider family history of lung cancer, as well as age and smoking status.
Lung cancer screening will reveal a multitude of incidental findings, of variable clinical significance, and with a need for clear pathways of management.
Pulmonary nodule sampling is enhanced by intra‐procedural imaging and cutting‐edge robotic technology.
Systematic thoracic lymph node sampling has implications for treatment efficacy.
Bronchoscopic ablative techniques are feasible for peripheral lung cancers.
Bronchoscopic sampling continues to have a high yield for lung cancer molecular characterization.
Immunotherapy indications have expanded to include early stage and resectable lung cancer.
The gamification of dating online
Authors: Nader Karim 
Published: July 2024

AbstractDating apps such as Tinder are designed to be played like a game. Users play by swiping left and right on others' profiles to indicate whether they are romantically or sexually interested in them. They match with those who reciprocate their interest. The goal of the game is to match with as many people as possible, prioritizing rapid gratification over the pursuit of meaningful connections. Tinder's design elements and monetization strategies incentivize users to prioritize gathering matches, replacing the complexity of actual dating with a series of discrete decisions. Playing the matching game on Tinder makes dating more immediately gratifying, so users have started to play the game as an end in itself. The app becomes a source of entertainment instead of a means to build valuable connections. This also transforms the activity of dating as users spend time building appealing profiles and attempt to manipulate the algorithm to maximize their matching potential. Gamifying our romantic and sexual lives has negative consequences on people's self‐image as their personal worth becomes entwined with their success on the app. Individuals are reduced to mere players in the game, and the algorithm itself disproportionately favors users with conventional preferences. Gamification can be dangerous when the boundary between the game and real life blurs.
Syntactic Variation in Reduced Registers Through the Lens of the Parallel Architecture
Authors: Smirnova Anastasia 
Published: July 2024

AbstractDiversion from the syntactic norm, as manifested in the absence of otherwise expected lexical and syntactic material, has been extensively studied in theoretical syntax. Such modifications are observed in headlines, telegrams, labels, and other specialized contexts, collectively referred to as “reduced” registers. Focusing on search queries, a type of reduced register, I propose that they are generated by a simpler grammar that lacks a full‐fledged syntactic component. The analysis is couched in the Parallel Architecture framework, whose assumption of relative independence of linguistic components—their parallelism—and the rejection of syntactocentrism are essential to explain properties of queries.
Irreducible Complexity of Hox Gene: Path to the Canonical Function of the Hox Cluster
Authors: Kulakova Milana A. , Maslakov Georgy P. , Poliushkevich Liudmila O. 
Published: July 2024

Abstract
The evolution of major taxa is often associated with the emergence of new gene families. In all multicellular animals except sponges and comb jellies, the genomes contain Hox genes, which are crucial regulators of development. The canonical function of Hox genes involves colinear patterning of body parts in bilateral animals. This general function is implemented through complex, precisely coordinated mechanisms, not all of which are evolutionarily conserved and fully understood. We suggest that the emergence of this regulatory complexity was preceded by a stage of cooperation between more ancient morphogenetic programs or their individual elements. Footprints of these programs may be present in modern animals to execute non-canonical Hox functions. Non-canonical functions of Hox genes are involved in maintaining terminal nerve cell specificity, autophagy, oogenesis, pre-gastrulation embryogenesis, vertical signaling, and a number of general biological processes. These functions are realized by the basic properties of homeodomain protein and could have triggered the evolution of ParaHoxozoa and Nephrozoa subsequently. Some of these non-canonical Hox functions are discussed in our review.
Activity of DNA Repair Systems in the Cells of Long-Lived Rodents and Bats
Authors: Popov Aleksei A. , Petruseva Irina O. , Lavrik Olga I. 
Published: July 2024

Abstract
Damages of various origin accumulated in the genomic DNA can lead to the breach of genome stability, and are considered to be one of the main factors involved in cellular senescence. DNA repair systems in mammalian cells ensure effective damage removal and repair of the genome structure, therefore, activity of these systems is expected to be correlated with high maximum lifespan observed in the long-lived mammals. This review discusses current results of the studies focused on determination of the DNA repair system activity and investigation of the properties of its key regulatory proteins in the cells of long-lived rodents and bats. Based on the works discussed in the review, it could be concluded that the long-lived rodents and bats in general demonstrate high efficiency in functioning and regulation of DNA repair systems. Nevertheless, a number of questions around the study of DNA repair in the cells of long-lived rodents and bats remain poorly understood, answers to which could open up new avenues for further research.