bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Deuterium Oxide on the Oxidative Stability and Change of Headspace Volatiles of Corn Oil
Authors: Kim JiYoung , Kim Mi‐Ja , Lee JaeHwan 
Published: December 2013

AbstractEffects of deuterium oxide and deuterium oxide‐free water on the oxidative stability and formation of headspace volatiles were determined for corn oils to evaluate the role of moisture as an active influential factors during lipid oxidation. Mixtures of corn oil and water with different ratios of deuterium oxide were prepared, and the mixtures were stored at 60 °C for 2 days. Headspace oxygen contents, conjugated dienoic acid (CDA) values, and p‐anisidine values (p‐AV) were analyzed as a measure of oxidative stability, and headspace volatiles were analyzed by solid phase microextraction and a gas chromatography mass selective detector to determine the involvement of deuterium in volatiles. Deuterium oxide accelerated the rate of lipid oxidation in corn oil compared to oils with deuterium‐free water based on the results of headspace oxygen content, CDA, p‐AV, and total volatile content. Fragmented mass to charge ratios (m/z) of 73.1/72.1 for d1‐pentane/pentane and 57.0/56.0 for d1‐2‐propenal/2‐propenal from samples containing deuterium oxide were significantly higher than those from deuterium oxide‐free water, implying that moisture participated to form volatiles in corn oil oxidation under air‐tight condition. Deuterium oxide appeared to accelerate the rate of lipid oxidation in corn oils and participated to form volatiles from oils during oxidation.
High trans,trans Conjugated Linoleic Acid‐Rich Triacylglyceride Production by Photo‐Irradiation
Authors: Shah Utkarsh , Proctor Andrew , Yettella Ramesh R. 
Published: December 2013

AbstractRecent studies have shown that a 20 % trans,trans conjugated linoleic acid (CLA)‐rich soy oil significantly reduces heart disease and diabetes risk factors in obese rats. Furthermore, trans,trans‐CLA has been reported to have superior anti‐carcinogenic activity than other CLA isomers. Therefore, a more concentrated source of trans,trans‐CLA oil would be highly desirable. The objectives of this study were to (1) determine the yield of trans,trans‐CLA isomers resulting from photo‐irradiation of Tonalin® (BASF Global, Florham Park, NJ, USA) and identify trans,trans‐CLA positional isomers; and (2) derive a mathematical model of kinetics of trans,trans‐CLA TAG formation from Tonalin®. Fifty‐five percent trans,trans‐CLA rich oil was obtained in about 140 min when Tonalin® was photo‐isomerized with 0.35 % iodine, which is almost three times more than is possible with photo‐isomerized soy oil. Photo‐isomerization of Tonalin® requires about 2 h, compared to 12 h for photo‐isomerization of soy oil. This reaction is a first‐order reversible reaction with the forward rate constant (kf) = 13.17 × 10−3min−1 and backward rate constant (kb) = 5.334 × 10−3min−1. The major isomers identified were trans‐9,trans‐11‐ and trans‐10,trans‐12‐CLA.
Associations between brain morphology and outcome in schizophrenia in a general population sample
Authors: Jääskeläinen E. , Juola P. , Kurtti J. , Haapea M. , Kyllönen M. , Miettunen J. , Tanskanen P. , Murray G.K. , Huhtaniska S. , Barnes A. , Veijola J. , Isohanni M. 
Published: December 2013

AbstractObjectiveTo analyse associations between brain morphology and longitudinal and cross-sectional measures of outcomes in schizophrenia in a general population sample.MethodsThe sample was the Northern Finland 1966 Birth Cohort. In 1999–2001, structural brain MRI and measures of clinical and functional outcomes were analysed for 54 individuals with schizophrenia around the age of 34. Sex, total grey matter, duration of illness and the use of antipsychotic medication were used as covariates.ResultsAfter controlling for multiple covariates, increased density of the left limbic area was associated with less hospitalisations and increased total white matter volume with being in remission. Higher density of left frontal grey matter was associated with not being on a disability pension and higher density of the left frontal lobe and left limbic area were related to better functioning. Higher density of the left limbic area was associated with better longitudinal course of illness.ConclusionsThis study, based on unselected general population data, long follow-up and an extensive database, confirms findings of previous studies, that morphological abnormalities in several brain structures are associated with outcome. The difference in brain morphology in patients with good and poor outcomes may reflect separable aetiologies and developmental trajectories in schizophrenia.
Maternal serum AGEs levels in pregnancies associated with neural tube defects
Authors: Li Rulin , Yang Peiyao , Chen Xuyang , Wang Li 
Published: December 2013

AbstractAdvanced glycation end products (AGEs) plays an important role in diabetic embryopathy. AGE‐mediated DNA damage could be a significant factor in the teratogenicity. The aim of the present study was to evaluate the association between the AGEs level and neural tube defects (NTDs) occurrence risk. Forty‐eight mothers with NTD‐affected pregnancies and 50 normal mothers were selected in this study. Blood were collected from the mothers and were assayed for serum AGEs, malondiadehyde (MDA) and hemoglobin A1c (HbA1c). Data were analyzed by logistic regression method. The study indicated that there were significant but modest lower prevalence for cases mothers on age, BMI and glucose levels compared with controls. NTD‐affected mothers were significantly more likely to have higher AGEs levels (5.6 ± 0.48 AU vs. 4.6 ± 0.68 AUρ< 0.01) than controls. The AGEs levels were not correlated with MDA and HbA1c in NTDs mothers (r2= 0.0006p= 0.8691 andr2= 0.001p= 0.8172, respectively). The conclusion is that AGEs might be associated with NTDs occurrence.
Prevalence and complications of gallstone disease among pregnant women in a Nigerian hospital
Authors: Ibitoye Bolanle O. , Adisa Adewale O. , Makinde Olufemiwa N. , Ijarotimi Adebimpe O. 
Published: December 2013

AbstractObjectiveTo determine the prevalence of gallstone disease and its complications among pregnant women in a semi‐urban Nigerian setting.MethodsConsecutive consenting pregnant women presenting at the prenatal clinic of a Nigerian tertiary hospital were recruited over an 18‐month period. During routine obstetric ultrasound, the presence of gallstones and/or associated sequelae was investigated. Patients’ sociodemographic data and hemoglobin genotype were documented.ResultsOverall, 1283 pregnant women (14–43 years of age) were included in the study. Thirty‐seven (2.9%) had sonographic evidence of gallstones, 26 (2%) had biliary sludge, and 2 (0.2%) had gallbladder polyps. Twenty‐one (56.8%) of the 37 women with gallstones were 30 years of age or younger. Only 1 (1.2%) of 85 selected women in the first trimester of pregnancy with no gallstones who were followed throughout pregnancy developed gallstones in the third trimester. Overall, 3 (0.2%) women had clinical and radiologic evidence of acute calculous cholecystitis, 2 of whom underwent laparoscopic cholecystectomy after delivery.ConclusionThe present study demonstrated a low prevalence of gallstone disease and its acute complications among pregnant Nigerian women in a semi‐urban setting.
Evaluation of sucralfate enema in experimental diversion colitis
Authors: Pereira José Aires , Rodrigues Murilo Rocha , Sato Daniela Tiemi , Júnior Paulo Pedroso Silveira , Dias Alice Moreira , Silva Camila Gonçalves da , Martinez Carlos Augusto Real 
Published: December 2013

AbstractDiversion colitis (DC) is an inflammatory disease that develops in segments with fecal diversion. Sucralfate (SCF) complex, which consists of sucrose octasulfate and polyaluminum hydroxide, has been demonstrated to be effective in the treatment of different forms of colitis. However, until now, the effects of SCF have not been evaluated in DC.
Objective to evaluate whether the use of enemas containing SFC improves histological findings in experimental DC.
Methods Thirty-six rats underwent right colon bypass procedure through the creation of a proximal colostomy and a distal mucous fistula. The animals were divided into two groups according to the euthanization procedure to be performed two to four weeks after surgery. Each experimental group was divided into three subgroups of six animals, which were submitted to daily application of enemas containing saline solution 0.9% or SCF at concentrations of 1.0 g/kg/day or 2.0 g/kg/day, respectively. The diagnosis of DC in segments with fecal diversion was established by histopathological study considering the following
variables epithelial loss, formation of crypt abscesses, the population of goblet cells, inflammatory infiltrate and presence of fibrosis. For statistical analysis, the nonparametric Mann-Whitney and Kruskal-Wallis tests were used, with a significance level of 5% (p <0.05).
Results It was observed that the daily application of SCF enemas decreased epithelial loss, formation of colon crypt abscesses, inflammatory infiltrate and tissue fibrosis (p <0.05), unrelated to time of intervention. The intervention with SCF preserves the goblet cell population. The effects of the substance on the preservation of colonic epithelium; the decrease in the inflammatory process and subsequent abscess formation in the colon crypts are associated with the concentration used, whereas tissue fibrosis decrease is associated with the concentration and time of intervention.
Conclusion Preventive application of SCF enemas reduces the inflammatory process in the colon with fecal diversion
Implementation of a Colorectal Laparoscopic Surgical Program short-term Outcomes and Conversion rates
Authors: Alves Adriana Cherem , Queiroz Fábio Lopes de , Oliveira Teon Augusto Noronha de , França-Neto Paulo Rocha , Lamounier Paulo César de Carvalho , Lacerda-Filho Antônio 
Published: December 2013

Abstract
Purpose: although laparoscopic surgery for the treatment of colorectal diseases represents a major advance, it is currently performed in less than a third of patients undergoing colectomies. The aim of this study is to analyze the initial results of laparoscopic-assisted colorectal surgeries (LACS) performed in a department of Coloproctology in a tertiary hospital, as well as to study the impact of age, gender and body mass index (BMI) and use of ultrasonic scissors or vessel sealing devices in relation to conversion rate.
Methods: this is a prospective observational study with 215 patients who underwent LACS between January 2006 and June 2010 in the Department of Coloproctology at Felicio Rocho Hospital, Belo Horizonte. The data obtained from a specific electronic database included demographics, diagnosis, use of ultrasonic scissors or vessel sealing devices, reason for conversion, duration of hospitalization, lymph node harvest in cancer specimens, complications, and deaths.
Results: the laparoscopic-assisted approach corresponded to 36.4% of all colorectal surgeries performed during the study period. Most patients were female (74%), with a mean age of 53.2 years. Ultrasonic scissors or vessel sealing devices were used in 32% of LACS. Specimen extraction and anastomosis were performed through an auxiliary incision in most cases.The overall conversion rate was 12%, with a decrease of 47% after the first year. We did not observe any association between conversion rate and age, gender, BMI, and the use of ultrasonic scissors and vessel sealing devices. The average hospital stay was of 7.7 days and the overall rate of complications was 20%, including 10 anastomotic leaks (4.65%). The rate of postoperative mortality was 1.86%.
Conclusions: despite the difficulties related to the learning curve and unavailability of ultrasonic scissors or vessel sealing devices in most cases, the implementation of LACS in our department can be considered successful in relation to short-term results and conversion rates.
Quality of Life Analysis in Ostomized Colorectal Cancer Patients
Authors: Kimura Cristilene Akiko , Kamada Ivone , Guilhem Dirce , Monteiro Pedro Sadi 
Published: December 2013

AbstractIntroduction the oncological patient submitted to ostomy faces multiple losses which affect their quality of life.Objective: assess quality of life in ostomized patients due to colorectal cancer, regarding the physical, psychological, social and environmental relationships, treated at the Ostomy Program of the Health Department of Distrito Federal, Brazil.Methods: epidemiological-based, analytical, cross-sectional and descriptive study. The sample consisted of 54 patients enrolled in the Ostomy Program of the Health Department of Distrito Federal - Brazil. The WHOQOL-BREF questionnaire was used to evaluate quality of life. Data was analyzed by Microsoft ® Office Excel 2010 and SPSS 20.0.Results: the Physical, Social and Environmental aspects were correlated to the mean score, resulting in statistical significance (p<0.0001). The item “Positive feelings” in the Psychological Domain was the only one that did not achieve statistical significance.Conclusion: the results demonstrate that the care of cancer patients with ostomies should focus on the technical-scientific, political and socio-educational actions, to allow a multidisciplinary team to recognize health as a right for all, working to guarantee the health care process.
Neoadjuvant Therapy and Surgery in Rectal Adenocarcinoma: Analysis of Patients with Complete Tumor Remission
Authors: de Andrade V.A. , Leal R.F. , Fagundes J.J. , Rodrigues Coy C.S. , de Lourdes Setsuko Ayrizono M. 
Published: December 2013

AbstractIntroduction: the standard treatment for locally advanced extra-peritoneal rectal adenocarcinoma, consists of neoadjuvant treatment with radiotherapy and chemotherapy followed by total mesorectal excision.Objective: evaluate, retrospectively, the patients submitted to neoadjuvant therapy and surgery that presents with total remission of the lesion in the anatomopathological examination.Methods: between 2000 and 2010, 212 patients underwent surgery at the Coloproctology Unit at DMAD at FCM–UNICAMP. They were grouped as: rectosigmoidectomy and colorectal anastomosis (n = 54), rectosigmoidectomy with coloanal anastomosis (n = 41), 114 abdominoperineal resection of the rectum (n = 114) and other (n = 3).Results: thirty (14.2%) patients (mean age 57.6 years; 60% males) showed complete remission of the rectal lesion. 4 (13.3%) had compromised lymph nodes and/or lymphatic invasionAt follow-up (mean 51.9 months), 4 (13.3%) presented with local recurrence (one patient) or distant metastases (two patients had liver metastasis, one had liver and lung, and one had bone metastasis). The mean survival was 86.7%.Conclusion: patients with a complete tumor response show ed an increased survival rate, however, the same patients without evidence of residual tumors could develop local recurrence or distant metastases on a later follow-up.
Recurrent Aggressive Angiomyxoma*
Authors: Alencar Suelene Suassuna Silvestre de , Corrêa Romualdo da Silva , Menezes Emanuela Simone Cunha de , Nascimento Antonio Luiz do , Costa Davi Aragão Alves da , Alencar Marcelo José Carlos 
Published: December 2013

Abstract
Introduction: aggressive angiomyxoma is a highly aggressive, rare neoplasm of the mesenchymal tissue with a high recurrence rate. It represents an important differential diagnosis of pelvic tumors in women of reproductive age. This study aims to describe a case of aggressive angiomyxoma.
Case report: woman, 37 years old, complained about a bulge on the right perianal region, and anal itching and burning, bleeding, tenesmus and incontinence. The proctologic examination confirmed the perianal bulge and extrinsic compression of the posterior wall of the rectum. Computed tomography (CT) of the pelvis showed a well-defined pelvic mass extending to the right rectal area. Exploratory laparotomy showed a mass of fibro elastic consistency adjacent to the pelvic organs and closely attached to the distal rectum, and performed a resection of the pelvic tumor afterward. Anatomopathological analysis revealed an aggressive angiomyxoma. Magnetic resonance imaging (MRI) of the pelvis showed signs of recurrence in the pelvic cavity on the right side of the rectum. A surgical procedure was performed to resect the lesion. After an asymptomatic period, the MRI showed solid growths located in the right ischiorectal fossa. A new surgical procedure identified only retention cysts in the pelvis and right ischiorectal fossa, only lysis of adhesions was performed. The patient is currently undergoing follow-up without disease recurrence.
Biological Therapy for Pyoderma Gangrenosum
Authors: Krüger Naw Ally , Marchi Jacqueline Jéssica De , Souza Mardem Machado de 
Published: December 2013

Abstract
Introduction: pyoderma gangrenosum (PG) is a rare and severe neutrophilic dermatosis associated with inflammatory bowel disease (IBD) and other systemic diseases such as rheumatoid arthritis and hematological malignancies. Diagnosis is based on clinical criteria and exclusion of other skin disorders. There is no gold standard for the treatment of PG; traditionally intravenous corticosteroids are used, but recently the use of drugs that inhibit tumor necrosis factor alpha (TNF-alpha) has changed the management of PG, showing great effectiveness.
Case report: female patient, 23 years old, diagnosed with severe nonspecific ulcerative colitis (UC) three years ago, undergoing treatment with oral mesalamine and azathioprine. She developed PG fourteen days after hospital discharge; hospitalization was due to worsening of intestinal disease symptoms. She was successfully treated using biological therapy after unfavorable evolution with corticosteroid therapy.
Conclusion: PG, a rare extraintestinal manifestation of IBD of difficult resolution that has significant impact on patient quality of life. The use of biological therapy for PG has higher efficacy in the treatment of patients decreasing wound healing time and return to daily activities.
Transanal minimally-invasive surgery (TAMIS): Technique and results from an initial experience
Authors: Mendes Carlos Ramon Silveira , Ferreira Luciano Santana de Miranda , Sapucaia Ricardo Aguiar , Lima Meyline Andrade , Araujo Sergio Eduardo Alonso 
Published: December 2013

AbstractTransanal endoscopic microsurgery is a minimally-invasive approach for rectal lesions. Superior exposure and access to the entire rectum result in lesser risk of compromised margins and lower recurrence rates, when compared to conventional transanal excision. The aim of this study was to describe a single institution's initial experience with transanal minimally invasive surgery (TAMIS). This was a prospective review of our database. Eleven procedures from January 2012 to June 2013 were analyzed.Results eleven operations were completed. Five men were evaluated. Mean age was 62.9 (40-86). Mean follow-up was 9.3 (2-17) months. Average tumor size was 3.8 (1.8-8) cm. Mean distance from anal verge was 6.3 (3-12) cm. Mean operating time was 53.73 (28-118) min. Postoperative complication rate was 9.1%. There were no readmissions. Mortality was null. Operative pathology disclosed the presence of adenoma in four patients, invasive adenocarcinoma in two, neuroendocrine carcinoma in three, and no residual lesion in one case. TAMIS is a minimallyinvasive procedure with low postoperative morbidity at the initial experience. TAMIS is a curative procedure for benign lesions and for selected early cancers. It is useful after neoadjuvant therapy for strictly selected cancers, pending the results of multi-institutional trials.
What are the risk factors for readmission in patients with an ileostomy?
Authors: Campos-Lobato Luiz Felipe de , Alves-Ferreira Patricia Cristina , Oliveira Paulo Gonçalves de , Sousa João Batista de , Vogel Jon D. 
Published: December 2013

AbstractPurpose the aim of this study was to identify the risk factors for readmission among patients submitted to colorectal surgery.Methods a single-center colorectal quality-assessment database was queried for patients undergoing colorectal procedures with ileostomy during 2009. the sample was divided into readmitted vs. non-readmitted. readmission was defined as admission within the first 30 days after the index procedure. Groups were compared by pre, intra and postoperative characteristics. A multivariate analysis was performed to identify the risk factors for readmission.Results the query returned 496 patients, [267 (54%) males, median age 48 years (iQr: 34-60)]. Eighty-three (17%) were readmitted; 296 patients (60%), were operated due to inflammatory bowel disease, 89 (18%) for cancer, 16 (3%) for diverticular disease and 95 (19%) for other diagnosis. the three most common procedures were total proctocolectomy with ileal pouch-anal anastomosis (iPAA) in 103 patients (21%), total colectomy with end ileostomy in 117 (24%) and small bowel resections (including enterocutaneous fistula takedown and J-pouch excision) in 149 (30%). the following variables were significantly more common in readmitted patients: current smoking (24% vs. 14%, p = 0.02), postoperative DVt/PE (10% vs. 4%, p = 0.04), wound infection (20% vs. 10% p = 0.01), sepsis (22% vs. 8% p < 0.001) and organ or space surgical site infection (orgSSi) (35% vs. 5%, p < 0.001). Postoperative orgSSi was the only independent factor associated with readmission in a multivariate analysis (p < 0.001).Conclusion colorectal surgeons should be alert for orgSSi when facing an ileostomy patient readmitted after a colorectal procedure.
Enhanced anticancer activity of a combination of docetaxel and Aneustat (OMN54) in a patient‐derived, advanced prostate cancer tissue xenograft model
Authors: Qu Sifeng , Wang Kendric , Xue Hui , Wang Yuwei , Wu Rebecca , Liu Chengfei , Gao Allen C. , Gout Peter W. , Collins Colin C. , Wang Yuzhuo 
Published: December 2013

The current first‐line treatment for advanced metastatic prostate cancer, i.e. docetaxel‐based therapy, is only marginally effective. The aim of the present study was to determine whether such therapy can be improved by combining docetaxel with Aneustat (OMN54), a multivalent botanical drug candidate shown to have anti‐prostate cancer activity in preliminary in vitro experiments, which is currently undergoing a Phase‐I Clinical Trial. Human metastatic, androgen‐independent C4‐2 prostate cancer cells and NOD‐SCID mice bearing PTEN‐deficient, metastatic and PSA‐secreting, patient‐derived subrenal capsule LTL‐313H prostate cancer tissue xenografts were treated with docetaxel and Aneustat, alone and in combination. In vitro, Aneustat markedly inhibited C4‐2 cell replication in a dose‐dependent manner. When Aneustat was combined with docetaxel, the growth inhibitions of the drugs were essentially additive. In vivo, however, the combination of docetaxel and Aneustat enhanced anti‐tumor activity synergistically and very markedly, without inducing major host toxicity. Complete growth inhibition and shrinkage of the xenografts could be obtained with the combined drugs as distinct from the drugs on their own. Analysis of the gene expression of the xenografts using microarray indicated that docetaxel + Aneustat led to expanded anticancer activity, in particular to targeting of cancer hallmarks that were not affected by the single drugs. Our findings, obtained with a highly clinically relevant prostate cancer model, suggest, for the first time, that docetaxel‐based therapy of advanced human prostate cancer may be improved by combining docetaxel with Aneustat.