bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preliminary feasibility study of a cognitive stimulation therapy programme for older adults with an intellectual disability
Authors: MacHale Rosemary , NíNeill Emma , Wyer Cathy , Corley Emma , McGuire Brian E. 
Published: August 2024

AbstractBackgroundDespite the increased risk for people with an intellectual disability developing dementia, post‐diagnostic psychosocial supports such as cognitive stimulation therapy (CST) are not routinely offered and there is limited research examining this intervention with people with intellectual disabilities. The aim of this study was to explore the feasibility of CST for older adults with intellectual disability to support active ageing.MethodsFive client participants attended a 14‐session CST group and four staff attended a focus group. Reflexive thematic analysis was used to investigate the client and staff narratives.ResultsThree key themes were generated: (1) Brain Health, (2) Connecting with others, and (3) Barriers and Enablers.ConclusionFindings indicated the suitability of CST as a way of supporting active ageing for older adults with intellectual disability. This study adds to the growing knowledge about service provision for older adults and their changing needs as they age and identifies clinical implications such as staff training to support intervention adherence.
Triple digital guides for implant‐supported restorations with alveoloplasty procedure in the esthetic zone
Authors: Zhang Xiaohan , Tang Chenxi , Yu Zhongyu , Peng Lin 
Published: August 2024

AbstractObjectiveThe principal aim of this report is to address the challenge of integrating prosthetic crowns with natural dentition in the esthetic zone. It highlights the utilization of a prosthetically driven treatment plan, designed to ensure predictable esthetic outcomes.Clinical ConsiderationsThis report details a technique that utilizes three digital guides, all derived from a 3‐dimensional digital smile design. The integration of a restoration guide, an implant drilling guide, and an alveoloplasty guide is described. These tools collectively facilitate the precise execution of both surgical and prosthetic procedures, enhancing treatment accuracy and esthetic integration.ConclusionsThis technique considers the esthetic prosthetic crowns, implant positions, and alveoloplasty collectively. It enhances the predictability of esthetic outcomes in oral implantology and potentially provides an integrated prosthetically driven workflow in cosmetic dental treatments.Clinical SignificanceThe application of multiple digital guides derived from the same prosthetically driven treatment significantly enhances the predictability of esthetic outcomes in oral implantology.
Associations between hearing loss, peripheral neuropathy, balance, and survival in older primary care patients
Authors: Mold James W. , Lawler Frank H. , Liao Xiaolan , Bard David E. 
Published: August 2024

AbstractBackgroundBoth age‐associated hearing loss (AAHL) and peripheral neuropathy (PN) are common in older patients, and both are associated with impaired balance, falls, and premature mortality. The objectives of this study were to document the prevalence and severity of AAHL in older primary care patients, and to explore associations between AAHL, PN, balance, falls, and mortality.MethodsWe analyzed information obtained in 1999 from 793 primary care patients recruited from practices participating in the Oklahoma Longitudinal Assessment of the Health Outcomes of Mature Adults (OKLAHOMA) Studies. Available data included demographic and health information, history of falls and hospitalizations, audiometry, balance testing, examination of the peripheral nerves, 50 foot timed gait, and dates of death up to 22 calendar years and 8106 person‐years of follow‐up. Proportionate hazards (PH) and structural equation modeling (SEM) were used to examine associations between AAHL, PN, balance, gait time, and mortality.Results501 of the 793 participants (63%) had AAHL. Another 156 (20%) had low frequency and 32 (4%) had unilateral deficits. Those with moderate or severe AAHL and the 255 (32%) with PN had impaired balance (p < 0.0001), increased gait time (p = 0.0001), and reduced survival time (p < 0.0001). In the PH model, both AAHL and PN were associated with earlier mortality (H.Rs. [95% C.I.]: 1.36 [1.13–1.64] and 1.32 [1.10–1.59] respectively). The combination of moderate or severe AAHL and PN, present in 24% of participants, predicted earlier mortality than predicted by either deficit alone (O.R. [95% C.I.I] 1.55 [1.25–1.92]). In the SEM models, the impacts of both moderate or severe AAHL and PN on survival were mediated, in part, through loss of balance.ConclusionsHearing loss and PN, both common in older patients, appear to be independently and additively associated with premature mortality. Those associations may be mediated in part by impaired balance. The Mechanisms are likely multiple and complex.
Intergenerational associations of maternal depression with daughters' family formation
Authors: Banchoff Emma M. , Axinn William G. , Ghimire Dirgha J. , Scott Kate M. 
Published: August 2024

AbstractObjectiveThis work investigates the potential associations between maternal major depressive disorder (MDD) and daughters' family formation behaviors, specifically the timing of marriage and first birth.BackgroundFamily and life course research has established the importance of intergenerational ties and linked lives for children's health, education, social life, and transition to adulthood more broadly. However, mothers' MDD has remained a relatively understudied factor shaping young people's family formation behaviors.MethodThe analyses used a sample of 1127 linked mother–father–daughter triads from the Chitwan Valley Family Study (CVFS) in Nepal. Discrete‐time event‐history models at the month level were run to assess whether daughters' differential exposure to maternal MDD was prospectively associated with entry into marital unions and parenthood.ResultsAlthough there was no relationship between maternal lifetime MDD and daughters' family formation, results showed that being first exposed to maternal MDD during childhood, specifically between the ages of 0 and 10, increased the monthly odds of transitioning to parenthood by more than 80%. Additional findings showed that an increased pace of getting married was a primary determinant of accelerated childbearing.ConclusionDaughters' exposure to mothers' depression was associated with daughters' family formation transitions. The timing of exposure, however, was a particularly important driver of that association. We argue that the study of parents' mental ill‐health provides untapped opportunity for future intergenerational research.
Computed tomographic re‐evaluation of skeletally immature French bulldogs previously diagnosed with humeral intracondylar fissure: 12 cases (2018‐2022)
Authors: Hutchings V. C. , Rutherford S. 
Published: August 2024

ObjectivesThe objective of this study was to present the follow‐up findings obtained through computed tomography in skeletally immature French bulldogs previously diagnosed with humeral intracondylar fissures.Materials and MethodsMedical records from a surgical referral centre between January 2018 and September 2022 were evaluated for all dogs with a humeral condylar fracture where preoperative CT of both humeri was performed. French bulldogs between the age of 12 weeks and 12 months were identified and evaluated for the presence of contralateral humeral intracondylar fissure. The dogs with follow‐up CT were evaluated for humeral intracondylar fissure resolution.ResultsA total of 137 humeral condylar fractures were operated on within the study period, 58 of which were in French bulldogs. Twenty‐seven French bulldogs had a contralateral humeral intracondylar fissure with 12 dogs matching the inclusion criteria. Follow‐up CT demonstrated resolution of the humeral intracondylar fissure in 11 (91.7%) of 12 cases.Clinical SignificanceContralateral humeral intracondylar fissures are common in skeletally immature French bulldogs sustaining humeral condylar fractures and the majority of these fissures tend to fuse within the follow‐up period. Due to the potential for breed variation in ossification of the humeral condyle, follow‐up CT may be warranted in skeletally immature French bulldogs before considering prophylactic transcondylar screw placement.
Plasma concentration of thrombopoietin in dogs with immune thrombocytopenia
Authors: Brooks Marjory B. , Brooks James C. , Catalfamo Jim , Zhu Yao , Goggs Robert , Babasyan Susanna , Wagner Bettina , LeVine Dana N. 
Published: August 2024

AbstractBackgroundImmune thrombocytopenia (ITP) is a common cause of severe thrombocytopenia in dogs. The pathogenesis of nonassociative, primary ITP (pITP) appears complex, with ill‐defined thrombopoietic response.ObjectivesDevelop an immunoassay to measure plasma canine thrombopoietin (TPO) concentration and characterize TPO concentrations in dogs with pITP.AnimalsForty‐one healthy dogs, 8 dogs in an induced ITP model (3 control, 5 ITP), and 58 pITP dogs.MethodsRecombinant canine TPO (rcTPO) was purchased and its identity confirmed by mass spectrometry. Monoclonal antibodies were raised to rcTPO and used to configure a sandwich ELISA using streptavidin‐biotin detection. Assay performance, coefficients of variability, and healthy dog plasma TPO reference interval (RI) were determined, followed by assay of ITP samples.ResultsAssay dynamic range was 15 pg/mL (lower limit of detection) to 1000 pg/mL TPO, with limit of quantitation of 62 pg/mL. Plasma TPO RI was 0 to 158 pg/mL, with plasma TPO <62 pg/mL for 35/41 healthy dogs. All dogs with induced ITP developed marked increases in plasma TPO concentration. Peak values ranged from 515 to >6000 pg/mL. In contrast, only 2/58 pITP dogs had TPO values above RI.Conclusions and Clinical ImportancePlasma TPO concentration is paradoxically low at diagnosis for most dogs with pITP. This finding suggests that ineffective thrombopoiesis contributes to thrombocytopenia in pITP dogs and supports evaluating TPO receptor agonist treatment as used for pITP in humans. The TPO assay provides a new tool to study thrombopoiesis in pITP and other thrombocytopenic syndromes in dogs.
Elderly patients with dysphagia in the intensive care unit: Association between malnutrition and delirium
Authors: Liang Xin , Li Xinya , Cheng Hongtao , Wei Fangxin , Li Tanjian , Li Yaqing , Huang YuTing , Lyu Jun , Wang Yu 
Published: August 2024

AbstractBackgroundDysphagia, as a geriatric syndrome, is prevalent in the intensive care unit (ICU). Malnutrition resulting from swallowing disorders is likely to correlate with adverse ICU outcomes, including delirium, thereby escalating the costs of care and hospitalization. However, malnutrition has not received the attention it deserves in ICU clinical nursing practice. As two preventable and correctable conditions—malnutrition and delirium—the advantages of early identification and intervention are substantial. Exploring the relationship between malnutrition and delirium, starting from the high‐risk group of elderly patients with swallowing difficulties in the ICU, will aid us in managing patients promptly and effectively.AimTo investigate the relationship between malnutrition and the incidence of delirium in elderly patients with dysphagia in the ICU.Study DesignThis is a retrospective study. Data for this study were obtained from the Medical Information Mart for Intensive Care‐IV. All 2273 patients included were dysphagia older patients over 65 years of age admitted to the ICU, and logistic regression was used to explore the relationship between malnutrition and delirium. We also used propensity score matching (PSM) for sensitivity analysis.ResultsAmong the included patients with swallowing difficulties, 13% individuals (297/2273) exhibited malnutrition, with a delirium incidence rate of 55.9% (166/297). In the non‐malnutrition group (1976/2273), the delirium incidence rate is 35.6% (704/1976). After adjusting for 31 covariates, multifactorial logistic regression showed that malnutrition was significantly positively associated with the incidence of delirium in elderly dysphagic patients in the ICU (adjusted odds ratio (OR) = 1.96, 95% confidence interval (CI) = 1.47–2.62). The results remained stable after analysis by PSM.ConclusionMalnutrition was significantly positively associated with the incidence of delirium in elderly dysphagic patients in the ICU. Malnutrition should be given adequate attention in the ICU.Relevance to Clinical PracticeICU nurses should pay particular attention to malnutrition, especially among the high‐prevalence group of patients with dysphagia. Early identification and nutritional intervention for these patients may help reduce the costs of care and health care expenditures.
The eukaryotic translation initiation factor eIF4E regulates flowering and circadian rhythm in Arabidopsis
Authors: Zhang Jing , Jin Huanhuan , Chen Yadi , Jiang Yonghong , Gu Lianfeng , Lin Guifang , Lin Chentao , Wang Qin 
Published: August 2024

SUMMARYTranslation initiation is a critical, rate‐limiting step in protein synthesis. The eukaryotic translation initiation factor 4E (eIF4E) plays an essential role in this process. However, the mechanisms by which eIF4E‐dependent translation initiation regulates plant growth and development remain not fully understood. In this study, we found that Arabidopsis eIF4E proteins are distributed in both the nucleus and cytoplasm, with only the cytoplasmic eIF4E being involved in the control of photoperiodic flowering. Genome‐wide translation profiling using Ribo‐tag sequencing reveals that eIF4E may regulate plant flowering by maintaining the homeostatic translation of components in the photoperiodic flowering pathway. eIF4E not only regulates the translation of flowering genes such as FLOWERING LOCUS T (FT) and FLOWERING LOCUS D (FLD) but also influences the translation of circadian genes like CIRCADIAN CLOCK ASSOCIATED 1 (CCA1) and PSEUDO‐RESPONSE REGULATOR 9 (PRR9). Consistently, our results show that the eIF4E modulates the rhythmic oscillation of the circadian clock. Together, our study provides mechanistic insights into how the protein translation regulates multiple developmental processes in Arabidopsis, including the circadian clock and photoperiodic flowering.
Special cubic zeros and the dual variety
Authors: Wang Victor Y. 
Published: August 2024

AbstractLet be a diagonal cubic form over in six variables. From the dual variety in the delta method of Duke–Friedlander–Iwaniec and Heath‐Brown, we unconditionally extract a weighted count of certain special integral zeros of in regions of diameter . Heath‐Brown did the same in four variables, but our analysis differs and captures some novel features. We also put forth an axiomatic framework for more general .
Children and young people’s preferences and needs when using health technology to self-manage a long-term condition: a scoping review
Authors: Court Rosemary Jane , Swallow Veronica , El-Yousfi Sarab , Gray-Burrows Kara , Sotir Fiona , Wheeler Gemma , Kellar Ian , Lee Jia Mang , Mitchell Robyn , Mlynarczyk Wiktoria , Ramavath Arnav , Dimitri Paul , Phillips Bob , Prodgers Lucy , Pownall Madeleine , Kowalczyk Marcin , Branchflower Jacob , Powell Lauren , Bhanbhro Sadiq , Weighall Anna , Martin-Kerry Jacqueline 
Published: August 2024

BackgroundThe use of patient-facing health technologies to manage long-term conditions (LTCs) is increasing; however, children and young people (CYP) may have preferences about health technologies which they interact or engage with, that influence their decision to use these technologies.AimsTo identify CYP’s reported preferences about health technologies to self-manage LTCs.MethodsWe undertook a scoping review, searching MEDLINE, PsycINFO and CINAHL in July 2021. Searches were limited to papers published between January 2015 and July 2021. We included any health technologies used to manage physical and mental LTCs. Qualitative content analysis of study data was undertaken to categorise data into themes and quantitative data were described and visually represented. We engaged CYP with LTCs to support the review design, interpretation of findings and development of recommendations.Results161 journal articles were included, describing preferences of CYP. Most included studies were undertaken in high-income countries. CYP’s main preferences and needs were: design and functionality; privacy and sharing; customisation and personalisation of the technology; and interaction options within the technology.ConclusionsThis review highlights important preferences and needs that CYP may have before using technologies to self-manage their LTC. These should be considered when developing technology for this population. Future research should involve CYP throughout the development of the technologies, from identifying their unmet needs through to final design, development, evaluation and implementation of the intervention.
Posterior reversible encephalopathy syndrome (PRES) in classic Hodgkin’s lymphoma, complicated by anthracycline-induced cardiomyopathy
Authors: Hall Rose , Atmaja Bambang , Sharma Bhupinder , Cunningham David 
Published: August 2024

A woman in her 20s with no medical history was diagnosed with bulky stage II classic Hodgkin’s lymphoma after an 8-week history of shortness of breath, cough and lethargy. A regimen of doxorubicin (Adriamycin), bleomycin, vinblastine and dacarbazine (ABVD) was commenced with six cycles planned. During the first cycle, the patient was profoundly hypertensive. She then suffered two self-terminating tonic-clonic seizures.Examination and investigations diagnosed posterior reversible encephalopathy syndrome (PRES), which resolved completely in 11 days with strict blood pressure control and withholding chemotherapy. Treatment was further complicated by anthracycline-induced cardiomyopathy, requiring a switch in regimen to gemcitabine BVD.The patient made a full recovery from neurology and cardiology perspectives and completed six cycles of chemotherapy, achieving a complete metabolic response by the tumour. We illustrate the case, describe differential diagnoses and management of PRES, its association with chemotherapy and the successful chemotherapy rechallenge.
Adverse events and perceived abandonment: learning from patients’ accounts of medical mishaps
Authors: Schlesinger Mark , Dhingra Isha , Fain Barbara A , Prentice Julia C , Parkash Vinita 
Published: August 2024

BackgroundAdverse medical events affect 10% of American households annually, inducing a variety of harms and attitudinal changes. The impact of adverse events on perceived abandonment by patients and their care partners has not been methodically assessed.ObjectiveTo identify ways in which providers, patients and families responded to medical mishaps, linking these qualitatively and statistically to reported feelings of abandonment and sequelae induced by perceived abandonment.MethodsMixed-methods analysis of responses to the Massachusetts Medical Errors Recontact survey with participants reporting a medical error within the past 5 years. The survey consisted of forty closed and open-ended questions examining adverse medical events and their consequences. Respondents were asked whether they felt ‘that the doctors abandoned or betrayed you or your family’. Open-ended responses were analysed with a coding schema by two clinician coders.ResultsOf the 253 respondents, 34.5% initially and 20% persistently experienced abandonment. Perceived abandonment could be traced to interactions before (18%), during (34%) and after (45%) the medical mishap. Comprehensive post-incident communication reduced abandonment for patients staying with the provider associated with the mishap. However, 68.4% of patients perceiving abandonment left their original provider; for them, post-error communication did not increase the probability of resolution. Abandonment accounted for half the post-event loss of trust in clinicians.LimitationsSurvey-based data may under-report the impact of perceived errors on vulnerable populations. Moreover, patients may not be cognizant of all forms of adverse events or all sequelae to those events. Our data were drawn from a single state and time period.ConclusionAddressing the deleterious impact of persisting abandonment merits attention in programmes responding to patient safety concerns. Enhancing patient engagement in the aftermath of an adverse medical event has the potential to reinforce therapeutic alliances between patients and their subsequent clinicians.
Optimising antibacterial utilisation in Argentine intensive care units: a quality improvement collaborative
Authors: Jorro-Baron Facundo , Loudet Cecilia Inés , Cornistein Wanda , Suarez-Anzorena Inés , Arias-Lopez Pilar , Balasini Carina , Cabana Laura , Cunto Eleonora , Corral Pablo Rodrigo Jorge , Gibbons Luz , Guglielmino Marina , Izzo Gabriela , Lescano Marianela , Meregalli Claudia , Orlandi Cristina , Perre Fernando , Ratto Maria Elena , Rivet Mariano , Rodriguez Ana Paula , Rodriguez Viviana Monica , Vilca Becerra Jacqueline , Villegas Paula Romina , Vitar Emilse , Roberti Javier , García-Elorrio Ezequiel ,   COST Collaborative Group, Rodriguez Viviana 
Published: August 2024

BackgroundThere is limited evidence from antimicrobial stewardship programmes in less-resourced settings. This study aimed to improve the quality of antibacterial prescriptions by mitigating overuse and promoting the use of narrow-spectrum agents in intensive care units (ICUs) in a middle-income country.MethodsWe established a quality improvement collaborative (QIC) model involving nine Argentine ICUs over 11 months with a 16-week baseline period (BP) and a 32-week implementation period (IP). Our intervention package included audits and feedback on antibacterial use, facility-specific treatment guidelines, antibacterial timeouts, pharmacy-based interventions and education. The intervention was delivered in two learning sessions with three action periods along with coaching support and basic quality improvement training.ResultsWe included 912 patients, 357 in BP and 555 in IP. The latter had higher APACHE II (17 (95% CI: 12 to 21) vs 15 (95% CI: 11 to 20), p=0.036), SOFA scores (6 (95% CI: 4 to 9) vs 5 (95% CI: 3 to 8), p=0.006), renal failure (41.6% vs 33.1%, p=0.009), sepsis (36.1% vs 31.6%, p<0.001) and septic shock (40.0% vs 33.8%, p<0.001). The days of antibacterial therapy (DOT) were similar between the groups (change in the slope from BP to IP 28.1 (95% CI: −17.4 to 73.5), p=0.2405). There were no differences in the antibacterial defined daily dose (DDD) between the groups (change in the slope from BP to IP 43.9, (95% CI: −12.3 to 100.0), p=0.1413).The rate of antibacterial de-escalation based on microbiological culture was higher during the IP (62.0% vs 45.3%, p<0.001).The infection prevention control (IPC) assessment framework was increased in eight ICUs.ConclusionImplementing an antimicrobial stewardship program in ICUs in a middle-income country via a QIC demonstrated success in improving antibacterial de-escalation based on microbiological culture results, but not on DOT or DDD. In addition, eight out of nine ICUs improved their IPC Assessment Framework Score.