bluuebunny/crossref_metadata_2025_split huggingface dataset:
The New Space Ecosystem: Insights from the Architecture of Digital Platforms
Authors: Abed Alghani Khaled , Kohtamäki Marko , Kuusniemi Heidi 
Published: August 2024

AbstractOriginally confined to the governmental sector, the space ecosystem has recently undergone a transformative shift with the private sector’s penetration redefining the established dynamics. Concurrently, the advent of digitalization and the influence of the capitalist mindset have contributed to a further reshaping of the space ecosystem. This convergence of forces signaled the dawn of the “New Space” era, prompting architectural modifications across the entire ecosystem. However, a comprehensive understanding of the architecture of the New Space Ecosystem remains elusive. Therefore, our primary objective is to conduct a systematic review to unveil and elucidate the architectural intricacies of the New Space Ecosystem. In our investigation, we have identified remarkable parallels between the architecture of the digital platform ecosystem and that of the New Space. Consequently, we posit that leveraging the existing literature on digital platform ecosystems may serve as a valuable bedrock for unraveling the complexities inherent in the New Space Ecosystem. Accordingly, our study makes three substantial contributions: (1) identifying the key dynamics that have shaped the architecture of the New Space Ecosystem, (2) delineating the distinct layers composing the New Space Ecosystem, and (3) proposing a prospective research agenda derived from the parallels drawn with the digital platform ecosystem.
Exploring Emerging Business Model Value Chains in New Space
Authors: Baber William W. , Ojala Arto 
Published: August 2024

AbstractOver the past twenty years, business activities related to opportunities provided by New Space have undergone constant change. These changes challenge existing business models and value chains. In this work, we discuss these changes based on the literature, expert interviews, and case examples from the industry. We demonstrate eight different value chains in New Space business. These include conventional value chains as well novel ones, all in the context of space business. The value chains investigated are at different levels of abstraction and include data, hardware, intellectual property, prestige, mission planning, tourism, and space services. The eighth value chain is an aggregated overview of the whole of New Space business. Furthermore, we discuss business opportunities within these value chains and provide insights into totally new business model value chains that are emerging in New Space. Lastly, we consider feedback loops in the value chains of New Space that should be understood by academic researchers and business managers.
Effects of chronic insecticide exposure on neuronal network development in vitro in rat cortical cultures
Authors: van Melis Lennart V. J. , Peerdeman Anneloes M. , González Celia Arenas , van Kleef Regina G. D. M. , Wopken J. Pepijn , Westerink Remco H. S. 
Published: August 2024

AbstractDevelopmental exposure to carbamates, organophosphates, and pyrethroids has been associated with impaired neurodevelopmental outcomes. Sex-specific differences following chronic insecticide exposure are rather common in vivo. Therefore, we assessed the chronic effects of in vitro exposure to different carbamates (carbaryl, methomyl and aldicarb), organophosphates [chlorpyrifos (CPF), chlorpyrifos-oxon (CPO), and 3,5,6,trichloropyridinol (TCP)], and pyrethroids [permethrin, alpha-cypermethrin and 3-phenoxy benzoic acid (3-PBA)] on neuronal network development in sex-separated rat primary cortical cultures using micro-electrode array (MEA) recordings. Our results indicate that exposure for 1 week to carbaryl inhibited neurodevelopment in male cultures, while a hyperexcitation was observed in female cultures. Methomyl and aldicarb evoked a hyperexcitation after 2 weeks of exposure, which was more pronounced in female cultures. In contrast to acute MEA results, exposure to ≥ 10 µM CPF caused hyperexcitation in both sexes after 10 days. Interestingly, exposure to 10 µM CPO induced a clear hyperexcitation after 10 days of exposure in male but not female cultures. Exposure to 100 µM CPO strongly inhibited neuronal development. Exposure to the type I pyrethroid permethrin resulted in a hyperexcitation at 10 µM and a decrease in neuronal development at 100 µM. In comparison, exposure to ≥ 10 µM of the type II pyrethroid alpha-cypermethrin decreased neuronal development. In female but not in male cultures, exposure to 1 and 10 µM permethrin changed (network) burst patterns, with female cultures having shorter (network) bursts with fewer spikes per (network) burst. Together, these results show that MEA recordings are suitable for measuring sex-specific developmental neurotoxicity in vitro. Additionally, pyrethroid exposure induced effects on neuronal network development at human-relevant concentrations. Finally, chronic exposure has different effects on neuronal functioning compared to acute exposure, highlighting the value of both exposure paradigms.
Nucleophagy in Aspergillus oryzae is Mediated by Autophagosome Formation and Vacuole-Mediated Degradation
Authors: Hashimoto Mau , Kimura Satoshi , Arioka Manabu 
Published: August 2024

AbstractWe previously reported autophagy-mediated degradation of nuclei, nucleophagy, in the filamentous fungus Aspergillus oryzae. In this study, we examined whether nuclei are degraded as a whole. We generated A. oryzae mutants deleted for orthologs of Saccharomyces cerevisiae YPT7 and ATG15 which are required, respectively, for autophagosome-vacuole fusion and vacuolar degradation of autophagic bodies. Degradation of histone H2B-EGFP under starvation conditions was greatly decreased in the ΔAoypt7 and ΔAoatg15 mutants. Fluorescence and electron microscopic observations showed that autophagosomes and autophagic bodies surrounding the entire nuclei were accumulated in the cytoplasm of ΔAoypt7 and the vacuole of ΔAoatg15, respectively. These results indicate that nuclei are engulfed in the autophagosomes as a whole and transported/released into the vacuolar lumen where they are degraded.
Differential effect of surgical technique on intravesical recurrence after radical nephroureterectomy in patients with upper tract urothelial cancer: a systematic review and Meta-analysis
Authors: Tsuboi Ichiro , Matsukawa Akihiro , Kardoust Parizi Mehdi , Klemm Jakob , Schulz Robert J , Cadenar Anna , Mancon Stefano , Chiujdea Sever , Fazekas Tamás , Miszczyk Marcin , Laukhtina Ekaterina , Kawada Tatsushi , Katayama Satoshi , Iwata Takehiro , Bekku Kensuke , Wada Koichiro , Gontero Paolo , Rouprêt Morgan , Teoh Jeremy , Singla Nirmish , Araki Motoo , Shariat Shahrokh F. 
Published: August 2024

Abstract
Context
Radical nephroureterectomy (RNU) with bladder cuff resection is the standard treatment in patients with high-risk upper tract urothelial cancer (UTUC). However, it is unclear which specific surgical technique may lead to improve oncological outcomes in term of intravesical recurrence (IVR) in patients with UTUC.

Objective
To evaluate the efficacy of surgical techniques and approaches of RNU in reducing IVR in UTUC patients.

Evidence Acquisition
Three databases were queried in January 2024 for studies analyzing UTUC patients who underwent RNU. The primary outcome of interest was the rate of IVR among various types of surgical techniques and approaches of RNU.

Evidence Synthesis
Thirty-one studies, comprising 1 randomized controlled trial and 1 prospective study, were included for a systematic review and meta-analysis. The rate of IVR was significantly lower in RNU patients who had an early ligation (EL) of the ureter compared to those who did not (HR: 0.64, 95% CI: 0.44–0.94, p = 0.02). Laparoscopic RNU significantly increased the IVR compared to open RNU (HR: 1.28, 95% CI: 1.06–1.54, p < 0.001). Intravesical bladder cuff removal significantly reduced the IVR compared to both extravesical and transurethral bladder cuff removal (HR: 0.65, 95% CI: 0.51–0.83, p = 0.02 and HR: 1.64, 95% CI: 1.15–2.34, p = 0.006, respectively).

Conclusions
EL of the affected upper tract system, ureteral management, open RNU, and intravesical bladder cuff removal seem to yield the lowest IVR rate in patients with UTUC. Well-designed prospective studies are needed to conclusively elucidate the optimal surgical technique in the setting of single post-operative intravesical chemotherapy.
Genotypic spectrum of ABCA4-associated retinal degenerations in 211 unrelated Mexican patients: identification of 22 novel disease-causing variants
Authors: Chacon-Camacho Oscar F. , Xilotl-de Jesús Nancy , Calderón-Martínez Ernesto , Ordoñez-Labastida Vianey , Neria-Gonzalez M. Isabel , Villafuerte-de la Cruz Rocío , Martinez-Rojas Augusto , Zenteno Juan Carlos 
Published: August 2024

AbstractThe purpose of this study was to analyze and molecularly describe the largest group of patients with ABCA4-associated retinal degeneration in Latin America. Pathogenic variants in ABCA4, a member of the ATP Binding Cassette (ABC) transporters superfamily, is one of the most common causes of inherited visual deficiency in humans. Retinal phenotypes associated with genetic defects in ABCA4 are collectively known as ABCA4-associated retinal degenerations (ABCA4R), a group of recessively inherited disorders associated with a high allelic heterogeneity. While large groups of Caucasian and Asiatic individuals suffering from ABCA4R have been well characterized, molecular information from certain ethnic groups is limited or unavailable, precluding a more realistic knowledge of ABCA4-related mutational profile worldwide. In this study, we describe the molecular findings of a large group of 211 ABCA4R index cases from Mexico. Genotyping was performed using either next generation sequencing (NGS) of a retinal dystrophy genes panel or exome. ABCA4 targeted mutation testing was applied to a subgroup of subjects in whom founder mutations were suspected. A total of 128 different ABCA4 pathogenic variants were identified, including 22 previously unpublished variants. The most common type of genetic variation was single nucleotide substitutions which occurred in 92.7% (408/440 alleles). According to the predicted protein effect, the most frequent variant type was missense, occurring in 83.5% of disease-causing alleles (368/440). Mutations such as p.Ala1773Val are fully demonstrated as a founder effect in native inhabitants of certain regions of Mexico. This study also gives us certain indications of other founder effects that need to be further studied in the near future. This is the largest molecularly characterized ABCA4R Latin American cohort, and our results supports the value of conducting genetic screening in underrepresented populations for a better knowledge of the mutational profile leading to monogenic diseases.
On the strength of Lagrangian duality in multiobjective integer programming
Authors: Brun Matthew , Perini Tyler , Sinha Saumya , Schaefer Andrew J. 
Published: August 2024

AbstractThis paper investigates the potential of Lagrangian relaxations to generate quality bounds on non-dominated images of multiobjective integer programs (MOIPs). Under some conditions on the relaxed constraints, we show that a set of Lagrangian relaxations can provide bounds that coincide with every bound generated by the convex hull relaxation. We also provide a guarantee of the relative quality of the Lagrangian bound at unsupported solutions. These results imply that, if the relaxed feasible region is bounded, some Lagrangian bounds will be strictly better than some convex hull bounds. We demonstrate that there exist Lagrangian multipliers which are sparse, satisfy a complementary slackness property, and generate tight relaxations at supported solutions. However, if all constraints are dualized, a relaxation can never be tight at an unsupported solution. These results characterize the strength of the Lagrangian dual at efficient solutions of an MOIP.
Retinal vasculitis after intravitreal aflibercept 8 mg for neovascular age-related macular degeneration
Authors: Matsumoto Hidetaka , Hoshino Junki , Numaga Saki , Mimura Kaori , Asatori Yosuke , Akiyama Hideo 
Published: August 2024

Abstract
Purpose
To evaluate short-term outcomes of intravitreal injection of aflibercept 8 mg for neovascular age-related macular degeneration (nAMD).

Study design
Retrospective, interventional case series.

Methods
We retrospectively studied 35 eyes of 34 consecutive patients with nAMD, assessing best-corrected visual acuity (BCVA), foveal thickness (FT), and central choroidal thickness (CCT) before and 4 weeks after the initial intravitreal dose of aflibercept 8 mg. The rate of achieving a dry macula and the incidence of intraocular inflammation (IOI) at week 4 were also determined.

Results
BCVA showed significant improvement, with significant reductions in FT and CCT 4 weeks after the initial injection of aflibercept 8 mg (all P < 0.01), with a dry macula being achieved in 20 eyes (57.1%). However, 3 eyes (8.6%) developed non-infectious IOI associated with retinal vasculitis, an adverse event not reported previously. The IOI in these eyes was relatively mild and treated with a posterior subtenon injection of triamcinolone acetonide with or without betamethasone eye drops, resulting in amelioration of IOI without any visual loss.

Conclusions
Intravitreal aflibercept 8 mg appears to be effective for improving visual acuity and ameliorating exudative changes in eyes with nAMD. However, special attention should be given to the potential development of IOI associated with retinal vasculitis.
The potential longevity-promoting hypoxic-hypercapnic environment as a measure for radioprotection
Authors: David Elroei , Wolfson Marina , Muradian Khachik K. , Fraifeld Vadim E. 
Published: August 2024

AbstractMany biological mechanisms of aging well converge with radiation’s biological effects. We used scientific insights from the field of aging to establish a novel hypoxic-hypercapnic environment (HHE) concept for radioprotection. According to this concept, HHE which possesses an anti-aging and longevity-promoting potential, should also act as a radiomitigator and radioprotector. As such, it might contribute greatly to the safety and wellbeing of individuals exposed to high levels of radiation, whether in planned events (e.g. astronauts) or in unplanned events (e.g. first responders in nuclear accidents).
Cloning, expression and characterisation of a novel mollusc α-1,2-Fucosyltransferase from Crassostrea gigas (CgFUT2)
Authors: Zemkollari Marilica , Ruprecht Colin , Blaukopf Markus , Grabherr Reingard , Staudacher Erika 
Published: August 2024

AbstractGlycans containing fucose play crucial roles in cell biology, particularly in recognition processes. In humans, fucose found in H-blood group antigens is recognized by various pathogens, thereby influencing host-pathogen interactions. However, in invertebrate biology the specific functions of these modifications and the corresponding glycosyltransferases are not fully elucidated. Therefore, cloning these glycosyltransferases from different model systems will provide valuable insights into this process. Little is known about fucosyltransferases in molluscs. For this study, a sequence of the Pacific oyster, Crassostrea gigas, based on amino acid sequence homologies with rabbit and human α-1,2-fucosyltransferases, was chosen. The recombinant enzyme (350 amino acids) was able to transfer fucose from GDP-fucose to the galactose residue of type II disaccharides, terminal galactoses in complex N-glycan structures and several linear and branched galactans which were tested using a glycan microarray. The α-1,2-linkage formed was confirmed by NMR analysis. The enzyme was active in a broad pH-range, it was relatively stable upon storage conditions and its activity was not dependent on the presence of divalent cations. In this study, we were able to clone, express and characterise a novel α-1,2-fucosyltrasferase from Crassostrea gigas (CgFUT2).
Social and Emotional Modes of Learning Within Digital Ecosystems: Emerging Research Agendas
Authors: Erstad Ola , Černochová Miroslava , Knezek Gerald , Furuta Takahisa , Takami Kyosuke , Liang Changhao 
Published: August 2024

AbstractThis article brings together literature and perspectives that have evolved during the last decade on issues of social and emotional aspects of learning in a digital age. This topic points to some core challenges and worries of contemporary social developments within digitalized societies, and ways of perceiving future developments of how we conceptualize learning and education within and beyond formal schooling to better provide for ways of engaging young learners. The aim is to address some emerging issues on the importance of digital social and emotional skills (D-SEL) relevant for our understanding of learning and education in contemporary and future societies. We use developments in selected countries (Norway, Czech Republic, USA and Japan) as examples to discuss how social and emotional skills have entered educational systems. The findings show that not only knowledge in a cognitive sense is important for human life, but also people’s approach to life and their ability to adapt to changes as digital social and emotional ways of learning.
Short-term deceleration capacity: a novel non-invasive indicator of parasympathetic activity in patients undergoing pulmonary vein isolation
Authors: Zarębski Łukasz , Futyma Piotr 
Published: August 2024

Abstract
Background
Subtypes of atrial fibrillation (AF) can differ, and exact mechanisms in which patients benefit from the pulmonary vein isolation (PVI) remain not fully understood. During PVI, vagal innervation of the heart may also be affected. Thus, non-invasive methods of intraprocedural assessment of such PVI impact are sought.

Methods
From 1-minute ECG recordings performed before and after PVI, we investigated short-term deceleration capacity (ST-DC) and short-term heart rate variability (ST-HRV) to determine their potential as indicators of parasympathetic activity before and after ablation.

Results
In 24 consecutive patients with paroxysmal AF included in the study, there were a significant differences in ST-DC and ST-HRV parameters measured before and after PVI. After 3 months, patients with baseline ST-DC ≥ 7.5 ms were less likely to experience AF recurrence when compared to patients with baseline ST-DC < 7.5 ms (0% vs 31%, p = 0.0496). There were no differences in AF recurrence after 12 months of follow-up (36% vs 38%, p = 0.52).

Conclusion
PVI leads to significant changes in ST-DC and ST-HRV, and these parameters can serve as indicators of vagal denervation after AF ablation. Patients with more prominent baseline ST-DC are less likely to experience AF recurrence during the post-PVI 3-month blanking period.

Graphical Abstract
Predicted future range expansion of a small carnivore: swift fox in North America
Authors: Nelson Dana L. , Marneweck Courtney J. , McShea William J. , Shamon Hila , Jachowski David S. 
Published: August 2024

Abstract
Context
Small carnivores are declining globally due to a complex suite of threats. Conservation of these species requires an understanding of their distributions and potential responses to future land-use and climate change.

Objectives
We modelled species-environment relationships of swift fox (Vulpes velox), a species of concern across their range. We developed spatial projections of current and future distribution to aid in conservation planning.

Methods
We assembled swift fox occurrence data from managers and community science sources to develop ensemble distribution models. In addition to landscape and climatic predictors, we developed a model of red fox distribution to represent effects of competition. We forecasted spatial predictions into the year 2070 under two climate change scenarios representing high (SSP 5–8.5) and low (SSP 1–2.6) emissions scenarios.

Results
Percent cover by grassland, mean annual precipitation, and minimum temperature of the coldest quarter were the three most important variables for swift fox distribution. Current suitable habitat for swift fox extends across 16 North American states and provinces. Future projections of swift fox distribution suggest an overall increase in area of swift fox suitable habitat under both emissions scenarios of > 56.9%, though patterns of gain and loss vary spatially.

Conclusions
The expansion of suitable habitat in future scenarios reflects swift fox adaptability to multiple land uses in a period following multi-organizational conservation efforts. Our spatial projections can be used in conservation planning and can serve as a case study of a small carnivore species likely to recover under future change scenarios provided that threats are addressed and landscape-scale conservation efforts continue.
Comparison of clinical and radiological characteristics of inflammatory and non-inflammatory Rathke cleft cysts
Authors: Matsushita Shu , Shimono Taro , Maeda Hiroyuki , Tsukamoto Taro , Horiuchi Daisuke , Oura Tatsushi , Ishibashi Kenichi , Takita Hirotaka , Tatekawa Hiroyuki , Atsukawa Natsuko , Goto Takeo , Miki Yukio 
Published: August 2024

Abstract
Purpose
Rathke cleft cysts are commonly encountered sellar lesions, and their inflammation induces symptoms and recurrence. Cyst wall enhancement is related to inflammation; however, its range and frequency have not yet been investigated. This study aimed to investigate the clinical and radiological differences between inflammatory and non-inflammatory Rathke cleft cysts.

Methods
Forty-one patients who underwent cyst decompression surgery for Rathke’s cleft cysts between January 2008 and July 2022 were retrospectively analyzed. Based on the pathological reports, patients were divided into inflammatory and non-inflammatory groups. Clinical assessments, endocrinological evaluations, cyst content analysis, and imaging metrics (mean computed tomographic value, maximum diameter, mean apparent diffusion coefficient [ADC] value, and qualitative features) were analyzed. Receiver operating characteristic curve analysis was performed, to determine ADC cutoff values, for differentiating inflammatory group from non-inflammatory group.

Results
Totally, 21 and 20 cases were categorized into the inflammatory and non-inflammatory groups, respectively. The inflammatory group displayed a higher incidence of central diabetes insipidus (arginine vasopressin deficiency) (p = 0.04), turbid cyst content (p = 0.03), significantly lower mean ADC values (p = 0.04), and more extensive circumferential wall enhancement on magnetic resonance imaging (MRI) (p < 0.001). In the inflammatory group, all cases revealed circumferential wall enhancement, with some exhibiting thick wall enhancement. There were no significant differences in other radiological features. The ADC cutoff value for differentiating the two groups was 1.57 × 10−3 mm2/s, showing a sensitivity of 81.3% and specificity of 66.7%

Conclusion
Inflammatory Rathke cleft cysts tended to show a higher incidence of central diabetes insipidus and turbid cyst content. Radiologically, they exhibited lower mean ADC values and greater circumferential wall enhancement on MRI.