bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of the relation between depression, frailty, nutrition and quality of life among older adults: findings from a cross‐sectional study in Greece
Authors: Argyriou Chrysoula , Dimitriadou Ioanna , Saridi Maria , Toska Aikaterini , Lavdaniti Maria , Fradelos Evangelos C. 
Published: June 2024

AbstractBackgroundQuality of life (QOL) among older adults is a crucial aspect of geriatric care, particularly in the context of global demographic shifts toward ageing societies. Understanding the determinants of QOL in older adults is essential for developing effective interventions to promote well‐being in this population.MethodsThis cross‐sectional study conducted in Greece aimed to investigate the complex relationship between depression, frailty, nutritional status, and QOL on 90 older adults (aged ≤65). Assessment instruments including the World Health Organization Quality of Life (WHOQoL)‐BREF questionnaire, Geriatric Depression Scale (GDS), Clinical Frailty Scale (CFS), and Mini Nutritional Assessment (MNA) were utilised to evaluate various dimensions of QOL, depressive symptoms, frailty, and nutritional status.ResultsThe study revealed significant negative correlations between depression and frailty with all domains of QOL (P < 0.05), indicating that higher levels of depressive symptoms and frailty were associated with lower QOL across physical, psychological, social, and environmental dimensions. Conversely, positive correlations were found between nutritional status and all QOL domains (P < 0.05), suggesting that better nutritional status was linked to higher QOL. Multivariate logistic regression analysis further demonstrated associations between nutritional status and participant characteristics, with females being more likely to be malnourished (odds ratio (OR) = 6.56, P = 0.013), while better health status (OR = 0.34, P = 0.486) and marital status (OR = 0.02, P = 0.019) were protective against malnutrition.ConclusionThese findings underscore the interconnectedness of depression, frailty, and nutritional status in shaping QOL among individuals. Holistic interventions targeting mental health, physical vulnerability, and nutritional well‐being are essential for promoting overall well‐being and functional outcomes in this population.
Modeling and design of solar + storage‐powered community resilience hubs across California
Authors: Murphy Patrick M. , Kinkhabwala Yunus , Kwoka Bethany , Nunez Yanelli , Dillon Annelise , Amezcua‐Smith Audrey , Krieger Elena 
Published: June 2024

AbstractDistributed clean, reliable energy resources like solar plus battery storage (solar + storage) can reduce harmful emissions while supporting resilience. Solar + storage‐powered resilience hubs provide energy for critical services during disasters while increasing human adaptive capacity year round. We studied where utility rates, local climate, and historical injustice make solar + storage resilience hubs more valuable and more challenging.We modeled the economic and climate impacts of outfitting candidate hub sites across California with solar + storage for everyday operations and identified designs and costs required to withstand a range of outages considering weather impacts on energy needs and availability. We integrated sociodemographic data to prioritize the siting of resilience hubs, to focus potential policy and funding priorities on regions where solar + storage for resilience hubs is hard or expensive, and where populations are most in need.We identified almost 20,000 candidate buildings with more than 8 GW of total rooftop solar potential capable of reducing CO2 emissions by 5 million tons per year while providing energy for community resilience. Hub capacity for one of the most challenging missions—providing emergency shelter during a power outage and smoke event—could have a statewide average lifetime cost of less than $2000 per seat. We identified regional challenges including insufficient rooftop solar capacity in cities, low sunlight in northern coastal California, and high costs driven by utility rate structures in Sacramento and the Imperial Valley. Results show that rates and net metering rules that incentivize solar + storage during everyday operations decrease resilience costs.
Implementation of caring contacts using patient feedback to reduce suicide‐related outcomes following psychiatric hospitalization
Authors: Steinberg Rosalie , Amini Jasmine , Sinyor Mark , Mitchell Rachel H. B. , Schaffer Ayal 
Published: June 2024

AbstractIntroductionSuicide risk is substantially elevated following discharge from a psychiatric hospitalization. Caring Contacts (CCs) are brief communications delivered post‐discharge that can help to improve mental health outcomes.MethodThis three‐phase, mixed‐method quality‐improvement study revised an existing CC intervention using iterative patient and community feedback. Inpatients (n = 2) and community members (n = 13) participated in focus groups to improve existing CC messages (phases 1 and 2). We piloted these messages among individuals with a suicide‐related concern following discharge from an inpatient psychiatric hospitalization (n = 27), sending CCs on days 2 and 7 post‐discharge (phase 3). Phase 3 participants completed mental health symptom measures at baseline and day 7, and provided feedback on these messages.ResultsPhase 1 and 2 focus group participants indicated preferences for shorter, more visually appealing messages that featured personalized, recovery‐focused content. Phase 3 participants demonstrated reductions in depressive symptoms at day‐7 post‐discharge (−6.4% mean score on Hopkins‐Symptom‐Checklist, −9.0% mean score on Entrapment‐Scale). Most participants agreed that CC messages helped them feel more connected to the hospital and encouraged help‐seeking behavior post‐discharge.ConclusionThis study supports the use of an iterative process, including patient feedback, to improve CC messages and provides further pilot evidence that CC can have beneficial effects.
Outcome of Pneumocystis pneumonia in transplant and non‐transplant HIV‐negative immunocompromised patients
Authors: Albasata Hanan , Gioia Francesca , Jiang Yidi , Poutanen Susan M. , Hosseini‐Moghaddam Seyed M. 
Published: June 2024

AbstractBackgroundPrevious studies showed HIV‐negative immunocompromised patients are susceptible to Pneumocystis pneumonia (PCP). However, the PCP outcome has not been compared among HIV‐negative immunocompromised patients.MethodsIn this retrospective cohort study at the University Health Network, we included all HIV‐negative immunocompromised patients who fulfilled the European Organization for Research and Treatment of Cancer (EORTC) PCP diagnosis criteria from December 2018 to December 2019. We compared the demographics, comorbidities, course of illness, and PCP outcome (28‐day mortality and composite outcome [i.e., death or intensive care unit (ICU) admission]) between solid organ transplant (SOT) and non‐SOT patients.ResultsOf 160 non‐HIV patients with PCP diagnoses, 118 patients fulfilled EORTC criteria (76 males [64.4%], median [range] age: 65.5 [21–87] years). PCP presentation in SOT recipients (n = 14) was more severe than non‐SOT patients (n = 104): acute presentation (onset <7 days before admission: 11/14 [78.6%] vs. 51/104 [56%], p = .037), shortness of breath (100% vs. 75/104 [74.3%], p = .037), median [range] O2 saturation (88% [75%, 99%] vs. 92%[70%, 99%], p = .040), and supplemental O2 requirement (12/14 [85.7%] vs. 59/104 [56.7%], p = .044). The mortality [4/14, (28.6%) vs. 15/104 (14.4%), p = .176], ICU admission (10/14 [71.4%] vs. 18/104 [17.3%], p < .0001), and mechanical ventilation (8/14 [57.1%] vs. 18/104 [17.3%], p = .0007) in SOT patients was different from non‐SOT patients. In multivariable analysis, SOT recipients were at greater risk of composite outcome than non‐SOT patients (aOR [CI95%]: 12.25 [3.08–48.62], p < .001).ConclusionPCP presentation and outcomes in SOT recipients are more severe than in non‐SOT patients. Further studies are required to explore the biological reasons for this difference.
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Wild grass‐derived alleles represent a genetic architecture for the resilience of modern common wheat to stresses
Authors: Abdelrahman Mostafa , Gorafi Yasir Serag Alnor , Sulieman Saad , Jogaiah Sudisha , Gupta Aarti , Tsujimoto Hisashi , Nguyen Henry T. , Herrera‐Estrella Luis , Tran Lam‐Son Phan 
Published: June 2024

SUMMARYThis review explores the integration of wild grass‐derived alleles into modern bread wheat breeding to tackle the challenges of climate change and increasing food demand. With a focus on synthetic hexaploid wheat, this review highlights the potential of genetic variability in wheat wild relatives, particularly Aegilops tauschii, for improving resilience to multifactorial stresses like drought, heat, and salinity. The evolutionary journey of wheat (Triticum spp.) from diploid to hexaploid species is examined, revealing significant genetic contributions from wild grasses. We also emphasize the importance of understanding incomplete lineage sorting in the genomic evolution of wheat. Grasping this information is crucial as it can guide breeders in selecting the appropriate alleles from the gene pool of wild relatives to incorporate into modern wheat varieties. This approach improves the precision of phylogenetic relationships and increases the overall effectiveness of breeding strategies. This review also addresses the challenges in utilizing the wheat wild genetic resources, such as the linkage drag and cross‐compatibility issues. Finally, we culminate the review with future perspectives, advocating for a combined approach of high‐throughput phenotyping tools and advanced genomic techniques to comprehensively understand the genetic and regulatory architectures of wheat under stress conditions, paving the way for more precise and efficient breeding strategies.
Generating pathways to domestically sourced plasma‐derived medicinal products: Report from a workshop by the International Plasma and Fractionation Association and the Working Party on Global Blood Safety of the International Society of Blood Transfusion
Authors: Farrugia Albert , Perry Robert , Rossi Françoise , von Bonsdorff Leni , Bowie Glynis , Faber Jean‐Claude , Omarjee Jeh‐Han , Epstein Jay , White Jenny 
Published: June 2024

AbstractPlasma‐derived medicinal products (PDMPs) are recognized internationally as essential medicines required to treat various acute and chronic conditions including congenital deficiencies of plasma proteins in haemophilia and primary immune deficiency. Global provision of these medicines is dominated by a small number of commercial companies, influencing the price and availability of the products. Achieving a level of strategic independence from this dominance is now seen as a public health priority in many countries. During the Regional Congress of the International Society for Blood Transfusion (ISBT) in Cape Town, South Africa, in November 2023, around 50 delegates from 24 countries participated in a workshop (WS) organized jointly by the International Plasma and Fractionation Association (IPFA) and the ISBT Working Party on Global Blood Safety on pathways towards provision of PDMPs from domestic plasma independent of commercial purchase in the open market. The WS was structured around three themes, each addressed by a separate group:
Quality/safety requirements for plasma for fractionation (PfF)
Stepwise access for safe plasma proteins
Approaching contract fractionation
A synthesis of conclusions from these groups included the following:
The need to acquire support from government authorities for a national plasma policy, recognizing the difficulties posed by unstable political and bureaucratic environments.
The value of embedding plasma and PDMPs within a patient blood management (PBM) paradigm to promote optimal clinical use of PDMPs.
Training of blood/plasma collection personnel in the relevant principles of Good Manufacturing Practice (GMP), coupled with regulatory oversight of plasma product production in the engaged jurisdictions.
Appreciation that limited access to contract fractionation may necessitate a stepwise approach, which may include small‐scale preparation of versions of essential plasma proteins as an intermediate phase towards the manufacture of industrial‐scale PDMPs from domestic plasma.
A retrospective analysis of postpartum red blood cell transfusions at a tertiary care obstetric centre
Authors: Lasry Ariane , Adant Samuel , Farag Karen , Tidafi Celya , Wareham Cassandra , Malick Mandy , Roy‐Lacroix Marie‐Ève , Morin Pierre‐Aurèle , Sauvé Nadine 
Published: June 2024

AbstractBackground and ObjectivesPostpartum anaemia is a prevalent health problem. We aimed to determine the compliance rate for red blood cell (RBC) transfusion indication among postpartum women in a single tertiary care centre in Quebec, Canada.Materials and MethodsRetrospective cohort study including all women ≥6 h postpartum who received ≥1 RBC transfusion during their delivery hospitalization between January 2005 and February 2022. We determined our centre's compliance rate by indication as compared to current society guidelines, all published after 2015 (Network for the Advancement of Patient Blood Management, Haemostasis and Thrombosis [NATA], Royal College of Obstetricians and Gynaecologists [RCOG], American College of Obstetricians and Gynecologists [ACOG]). We then explored predictors of guideline non‐compliance and described transfusion practices in our centre.ResultsA total of 171 women were included. Our centre's compliance rate was 79.5% (95% confidence interval [CI] 72.7–84.8). Predictors of guideline non‐compliance were maternal medical comorbidity or abnormal placentation, both limited by large CIs (odds ratio [OR] 2.26, CI 1.02–4.94, p = 0.04; OR 4.00, CI 1.31–12.06, p = 0.01, respectively). Postpartum haemorrhage was diagnosed among 68% of the cohort, mostly due to uterine atony (73.3%). Mean baseline and nadir haemoglobin were 111 g/L (±18) and 62 g/L (±7.7), respectively. Multiple unit initial transfusion was found in a majority of patients (63.7%). Iron therapy was administered to 51.5% of women in‐hospital and 81.9% received an oral iron prescription at discharge. There were no differences in primary or secondary outcomes subsequent to relevant guideline publication.ConclusionOur centre's compliance rate for RBC transfusion indication meets current practice guidelines. Areas for improvement include single‐unit initial transfusion protocols and adjuvant iron treatment. Antenatal optimization of haemoglobin and ferritin stores may limit postpartum transfusions.
Sub‐Weyl type range for twisted GL(2)$\mathrm{GL(2)}$ short sums
Authors: Ghosh Aritra , Kummari Mallesham 
Published: June 2024

AbstractLet
where is a bump function supported on the interval [1,2] and satisfying and ’s are the normalized Fourier coefficients of Hecke eigenform, and is a primitive character of conductor . In this article, we prove a sub‐Weyl type cancellation range
provided that . Note that the above bound is nontrivial if .
Cost and cost-effectiveness of treatments for rheumatic heart disease in low- and middle-income countries: a systematic review protocol
Authors: Thangamma AG Mona , Vidyadharan Bhavya , Daniel Roshan P. , Sirur Andria , Kumar Praveen , Thunga P Girish , Gopal Poojari Pooja , Rashid Muhammed , Mukherjee Nirmalya , Bhattacharya Paramita , John Denny 
Published: June 2024

Objective:
This review will synthesize studies on costs, the impact of these costs, and the cost-effectiveness of treatments for rheumatic heart disease (RHD) in low- and middle-income countries.

Introduction:
RHD incurs high costs owing to its clinical complexity, surgical treatments, and prolonged hospital stays. Thus, the disease has a substantial economic impact on the health system, patients, and their families. No systematic review on economic evidence of treatments for RHD has been published to date.

Inclusion criteria:
This review will consider all cost and cost-effectiveness studies on RHD treatments for children and young adults (5─30 years) residing in low- and middle-income countries.

Methods:
The review will follow the JBI methodology for systematic reviews of economic evaluation evidence. The search strategy will locate published and unpublished studies in English. Systematic searches will be conducted in MEDLINE (PubMed), MEDLINE (Ovid), Embase (Ovid), Scopus, CINAHL (EBSCOhost), National Health Service Economic Evaluation Databases, Pediatric Economic Database Evaluation, and Cost-Effectiveness Analysis Registry. Two independent reviewers will screen titles and abstracts, followed by a full-text review based on the inclusion criteria. Data will be extracted using a modified JBI data extraction form for economic evaluations. JBI’s Dominance Ranking Matrix for economic evaluations will be used to summarize and compare the results of cost and cost-effectiveness studies. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach will be used to assess the certainty of economic evidence for outcomes related to resource use.

Review registration:
PROSPERO CRD42023425850
Transcriptome analysis of CpGV in midguts of type II resistant codling moth larvae and identification of contaminant infections by SNP mapping of RNA-Seq data
Authors: Yang Shili , Amberger Maximilian , Wennmann Jörg T. , Jehle Johannes A. 
Published: June 2024

ABSTRACT

Various isolates of the Cydia pomonella granulovirus (CpGV) are used as insect pest control agents against codling moth (CM,
Cydia pomonella
L.), a predominant pest in apple orchards. Three different types (I–III) of dominantly inherited field resistance of CM larvae to CpGV have been recently identified. In this study, transcription of virus genes in midgut cells of type II-resistant CM larvae infected with different CpGV isolates, i.e., CpGV-M and CpGV-S (both prone to type II resistance) as well as CpGV-E2 (breaking type II resistance) was determined by strand-specific RNA sequencing (RNA-Seq) at an early infection stage (72 h post infection). Based on principal component analysis of read counts and the quantitative distribution of single nucleotide polymorphisms (SNPs) in the RNA-Seq data, a bioinformatics analysis pipeline was developed for an
a posteriori
identification of the infective agents. We report that (i) identification of infective agent is crucial, especially in
in vivo
infection experiments, when activation of covert virus infections is a possibility, (ii) no substantial difference between CpGV-M and CpGV-S transcription was found in type II-resistant CM larvae despite a different resistance mechanism, (iii) the transcription level of CpGV-M and CpGV-S was much lower than that of CpGV-E2, and (iv)
orf59
(
sod
),
orf89
(
pif-6
)
, orf92
(
p18
), and
orf137
(
lef-10
) were identified as significantly downregulated genes in resistance-prone isolates CpGV-M and CpGV-S. For type II resistance of CM larvae, we conclude that CpGV-M and CpGV-S are both able to enter midgut cells, but viral transcription is significantly impaired at an early stage of infection compared to the resistance-breaking isolate CpGV-E2.

IMPORTANCE

CpGV is a highly virulent pathogen of codling moth, and it has been developed into one of the most successful commercial baculovirus biocontrol agents for pome fruit production worldwide. The emergence of field resistance in codling moth to commercial CpGV products is a threat toward the sustainable use of CpGV. In recent years, different types of resistance (type I–III) were identified. For type II resistance, very little is known regarding the infection process. By studying the virus gene expression patterns of different CpGV isolates in midguts of type II-resistant codling moth larvae, we found that the type II resistance mechanism is most likely based on intracellular factors rather than a receptor component. By applying SNP mapping of the RNA-Seq data, we further emphasize the importance of identifying the infective agents in
in vivo
experiments when activation of a covert infection cannot be excluded.
Complete genome sequence of multidrug-resistant
Raoultella terrigena
strain RT01-5M1 isolated from farmed salmon in Canada
Authors: Zhang Bei , Tan Tianbi , Smith Derek D. N. , Duceppe Marc-Olivier , Rudra Bashudev , Gupta Radhey S. , Ogunremi Dele 
Published: June 2024

ABSTRACT

The genome sequence of multidrug-resistant
Raoultella terrigena
RT01-5M1 strain isolated from Canadian farmed salmon was determined using Oxford nanopore and Illumina MiSeq sequencers. The assembled chromosome was estimated at 5,699,993 bp in size, with two plasmids, 164,879 bp and 82,046 bp. The chromosome and smaller plasmid contained antimicrobial resistance genes.
The basic leucine zipper domain (bZIP) transcription factor
BbYap1
promotes evasion of host humoral immunity and regulates lipid homeostasis contributing to fungal virulence in
Beauveria bassiana
Authors: Wang Guang , Chen Bin , Zhang Xu , Du Guangzu , Han Guangyu , Liu Jing , Peng Yuejin 
Published: June 2024

ABSTRACT

Basic leucine zipper domain transcription factors (TFs), of which yeast activator protein (Yap) is a significant class, are crucial for the development of sclerotia, the stress response, vegetative growth, and spore adhesion. Nevertheless, nothing is known about how Yap TFs contribute to the pathogenicity of entomopathogenic fungus. In this work,
Beauveria bassiana
was used to identify and knock out the yeast gene
BbYap1
, which is similar to Yap. The
BbYap1
gene deletion has an impact on lipid homeostasis of
B. bassiana
; oleic acid, for example, dropped by 95.69%. The
BbYap1
mutant exhibited much less virulence and vegetative development in comparison to the wild strain, while demonstrating a greater sensitivity to chemical stress. It is noteworthy that the physiological abnormalities brought on by
BbYap1
deletion were largely repaired by the addition of exogenous oleic acid, as seen by the notable increase in insect survival in the blood cavity injection group. Following infection with the
BbYap1
mutant, the host exhibits a considerable down-regulation of the expression of β-1,3-glucan recognition protein, gallerimycin, gloverin, and moricin-like protein genes. Likewise, the introduction of exogenous oleic acid markedly increased the host’s expression of the aforementioned genes. In summary,
BbYap1
regulates cellular enzyme lipid homeostasis and fungal virulence by eluding host humoral defense, which contributes to fungal chemical stress and vegetative development.

IMPORTANCE

Entomopathogenic fungi (EPF) offer an effective and eco-friendly alternative to curb insect populations in biocontrol strategy. When EPF enter the hemolymph of their host, they encounter a variety of stress reactions, such as immunological and oxidative stress. Basic leucine zipper domain transcription factors, of which yeast activator protein (Yap) is a significant class, have diverse biological functions related to metabolism, development, reproduction, conidiation, stress responses, and pathogenicity. This study demonstrates that
BbYap1
of
Beauveria bassiana
regulates cellular enzyme lipid homeostasis and fungal virulence by eluding host humoral defense, which contributes to fungal chemical stress and vegetative development. These findings offer fresh perspectives for comprehending molecular roles of YAP in EPF.