P-382 Clinical case studies of women achieving successful pregnancy outcomes in natural cycle endometrial preparation while continuing breastfeeding: a gap in the existing literature
Authors: Fernandez Sanguino A 
Published: July 2024

Abstract

Study question
Existing research in assisted reproductive technology excludes women who are breastfeeding.The influence of lactation on embryo transfer outcomes remains underexplored.

Summary answer
This collection of clinical cases underscores the viability of natural cycle endometrial preparation for women who wish to continue breastfeeding while pursuing fertility treatments.

What is known already
Endometrial preparation for embryo transfer often involves hormonal regimens and synchronization with the menstrual cycle. However, little attention has been given to women who choose to continue breastfeeding while pursuing fertility treatments. This study presents clinical case reports of women who successfully achieved ongoing pregnancies by utilizing natural cycle endometrial preparation during continued lactation, shedding light on a crucial gap in the current literature regarding embryo transfers in lactating women.

Study design, size, duration
A series of clinical case reports were analyzed, focusing on women who maintained breastfeeding while undergoing natural cycle endometrial preparation for embryo transfer. The cases encompass various age groups and underlying fertility issues. Data collected includes menstrual regularity, hormonal profile, and outcomes of embryo transfers.

Participants/materials, setting, methods
Retrospective review of a group of women of varying ages and fertility backgrounds who opted to continue breastfeeding while pursuing embryotransfer. We performed frozen embryo transferchoosing natural cycle endometrial preparation.
Clinical data were collected from the participants, including menstrual regularity, hormonal assesment, and outcomes of embryo transfers. Patients were monitored to determine the timing of natural ovulation. The women continued breastfeeding throughout their cycle, and embryo transfers were performed according to standard protocols.

Main results and the role of chance
Our preliminary findings indicate that women who continued breastfeeding during natural cycle endometrial preparation achieved successful pregnancies with evolving embryos. These case reports highlight the potential feasibility of this approach in fertility treatments, despite the limited scientific literature examining the impact of breastfeeding on embryo transfer outcomes.

Limitations, reasons for caution
Limited number of clinical cases, which may not fully represent the diversity of patient experiences. Additionally, the absence of a control group makes it challenging to draw definitive conclusions about the sole influence of breastfeeding on the outcomes. Future investigations should involve larger cohorts and controlled studies to provide evidence.

Wider implications of the findings
This collection of clinical cases underscores the viability of natural cycle endometrial preparation for women who wish to continue breastfeeding while pursuing fertility treatments.. These cases advocate for a broader understanding of reproductive options and potential adaptations to existing protocols for lactating women in the field of assisted reproductive technology.

Trial registration number
not aplicable