bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of Co-Morbid Mental Illness on the Diagnosis and Management of Patients Hospitalized for Medical Conditions in a General Hospital
Authors: Briskman I. , Bar G. , Boaz M. , Shargorodsky M. 
Published: September 2012

Aims: Comorbidities including hyperglycemia, diabetes, and hypertension are frequently observed in psychiatric patients. Nevertheless, this population has higher rates of morbidity and mortality from medical illnesses compared to non-psychiatric patients. The present study evaluated the diagnosis and management of general medical hospitalized patients with and without mental illness. Methods: The study group consisted of 200 hospitalized subjects including 100 subjects who met the DSM-IV criteria for schizophrenia or bipolar disorder and 100 age-matched controls. All patients were evaluated for a comorbid condition, concomitant medication, biochemical parameters. Comorbid conditions were defined using the National Cholesterol Education Program risk factors categories: diabetes (fasting plasma glucose level ⩾ 126 mg/dl and/or pharmacological treatment); hypertension (systolic blood pressure ⩾ 140 mm Hg and/or diastolic BP ⩾ 90 mm Hg and/or pharmacological treatment); dyslipidemia (hypertriglyceridemia (⩾ 150 mg/dl); and/or pharmacological treatment and/or low HDL cholesterol level (< 40 mg/dl in men and < 50 mg/dl in women). Results: The two groups were similar in terms of age, sex, mean blood pressure, glucose, and lipids. Patients with a history of psychiatric illness were less frequently diagnosed with medical conditions such as hypertension, dyslipidemia, and diabetes compared to the non-psychiatric population, though according NCEP criteria, these conditions did not significantly differ between the two groups. Significantly fewer psychiatric than non-psychiatric patients received aspirin, statins, anti-hypertensive and anti-diabetic medications. Although more obesity was diagnosed in psychiatric patients, significantly fewer diet consults were performed during hospitalization. While significantly more smokers and more pulmonary hospitalizations were observed in the psychiatric group, fewer subjects in this group received instruction for smoking cessation compared to the non-psychiatric population. Conclusions: Comorbid medical conditions such as diabetes, hypertension, dyslipidemia, and obesity are under-diagnosed and under-treated in hospitalized psychiatric patients compared with the non-psychiatric population. Patients with mental illness have significantly less preventive intervention during hospitalization.
Comparison of Multiple Carrier Disposition PWM Techniques Applied for Multi-Level Shunt Active Filter
Authors: Kathalingam Sebasthi , Karantharaj Porkumaran 
Published: September 2012

Comparison of Multiple Carrier Disposition PWM Techniques Applied for Multi-Level Shunt Active FilterThis work presents the simulation of a shunt active filter using seven-level cascaded inverter. The ultimate objective is to bring out the influence of multiple carrier level shifted PWM techniques on the performance of a shunt active filter. Classical disposition PWM techniques such as PD, POD and APOD have been used to generate the gating signals for the inverter active switches. A comparison is presented to substantiate the effect of these techniques in filtering. The comparison is made from the perspective of reduction in THD of source currents after filtering. For compensation current extraction synchronous detection method has been used. The harmonic reduction is achieved in source currents as well as source voltages.
One Way of Output Voltage Hold Circuit Improvement at Low Resistance Comparator
Authors: Radetić Radijle , Milivojević Dragan , Pavlov Marijana , Brodić Darko 
Published: September 2012

One Way of Output Voltage Hold Circuit Improvement at Low Resistance Comparator
The article presents a way of improvement the important performances of an electronic low resistance comparator. The practical usage of a realized instrument prototype shows some disadvantages: the time until the result appears at the display is to long (the stationary state establishing sequence should be shorter) because of the negative influence of parasitic voltages. Modification of output voltage hold circuit gives quite convenient instrument response time. The parasitic voltage disturbance is decreased to acceptable value, even though the comparator is modified for multirange measurement. The paper describes some details of a solution and its conformation in practical usage.
Spermine Oxidation Products Induce Mitochondrial Alterations on Tumor Cells
Authors: Agostinelli Enzo 
Published: September 2012

Spermine Oxidation Products Induce Mitochondrial Alterations on Tumor CellsCytotoxic products of polyamines generatedin situby an enzyme-catalyzed reaction may be useful as a new avenue in combating cancer. This study demonstrates that multidrug resistant (MDR) cancer cells (colon adenocarcinoma and melanoma) are significantly more sensitive than the corresponding wild type (WT) ones to hydrogen peroxide and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine. Transmission electron microscopy (TEM) observations showed the major ultrastructural alterations of the mitochondria. These were more pronounced in MDR than in WT cells. After treatment with BSAO/spermine a higher mitochondrial membrane depolarization and an increased mitochondrial activity in drug-resistant cells were observed. The results suggest that enzymatically formed cytotoxic agents activate stress signal transduction pathways, leading to apoptotic cell death, mainly in multidrug resistant cell lines.
The Effects of Biocompatible Compared with Standard Peritoneal Dialysis Solutions on Peritonitis Microbiology, Treatment, and Outcomes: The Balanz Trial
Authors:   The balANZ Trial Writing Committee:, Johnson David W. , Brown Fiona G. , Clarke Margaret , Boudville Neil , Elias Tony J. , Foo Marjorie W.Y. , Jones Bernard , Kulkarni Hemant , Langham Robyn , Ranganathan Dwarakanathan , Schollum John , Suranyi Michael G. , Tan Seng H. , Voss David 
Published: September 2012

Background A multicenter, multi-country randomized controlled trial (the balANZ study) recently reported that peritonitis rates significantly improved with the use of neutral-pH peritoneal dialysis (PD) solutions low in glucose degradation products (“biocompatible”) compared with standard solutions. The present paper reports a secondary outcome analysis of the balANZ trial with respect to peritonitis microbiology, treatment, and outcomes. Methods Adult incident PD patients with residual renal function were randomized to receive either biocompatible or conventional (control) PD solutions for 2 years. Results The safety population analysis for peritonitis included 91 patients in each group. The unadjusted geometric mean peritonitis rates in those groups were 0.30 [95% confidence interval (CI): 0.22 to 0.41] episodes per patient–year for the biocompatible group and 0.49 (95% CI: 0.39 to 0.62) episodes per patient–year for the control group [incidence rate ratio (IRR): 0.61; 95% CI: 0.41 to 0.90; p = 0.01]. When specific causative organisms were examined, the rates of culture-negative, gram-positive, gram-negative, and polymicrobial peritonitis episodes were not significantly different between the biocompatible and control groups, although the biocompatible group did experience a significantly lower rate of non-pseudomonal gram-negative peritonitis (IRR: 0.41; 95% CI: 0.18 to 0.92; p = 0.03). Initial empiric antibiotic regimens were comparable between the groups. Biocompatible fluid use did not significantly reduce the risk of peritonitis-associated hospitalization (adjusted odds ratio: 0.80; 95% CI: 0.48 to 1.34), but did result in a shorter median duration of peritonitis-associated hospitalization (6 days vs 11 days, p = 0.05). Peritonitis severity was more likely to be rated as mild in the biocompatible group (37% vs 10%, p = 0.001). Overall peritonitis-associated technique failures and peritonitis-related deaths were comparable in the two groups. Conclusions Biocompatible PD fluid use was associated with a broad reduction in gram-positive, gram-negative, and culture-negative peritonitis that reached statistical significance for non-pseudomonal gram-negative organisms. Peritonitis hospitalization duration was shorter, and peritonitis severity was more commonly rated as mild in patients receiving biocompatible PD fluids, although other peritonitis outcomes were comparable between the groups.
Transatlantic Online Community of Practice
Authors: Schwartz-Bechet Barbara , Bos-Wierda Roelien , Barendsen Ronald 
Published: September 2012

Global citizenship and an international orientation are high on the agenda in higher education both in Europe and in the USA. The realization of ambitions in this sphere is often problematic since student and staff exchange is a costly and time consuming affair. In this paper we will explore to what extent the use of technology may facilitate this process and what the added value is. To that end we will demonstrate how a university in the Netherlands and a university in the United States began a partnership in the area of teacher education. Through the use of technology, faculty and student teachers in the Netherlands and the USA socialize and collaborate on the secure educational platform Myschoolsnetwork.com. We will focus on the relationship between the social and the professional, the formal and the informal. We will demonstrate how parts of the US and NL curricula were synchronized and how students on both sides of the Atlantic uploaded lesson plans, webquests and classroom dilemmas .
We will discuss why and how we began our partnership and provide detailed instructions on how to achieve success in the development in a transatlantic partnership. and explore what factors determine success or failure. In the conclusion plans for the future will be described.
Topical Cyclosporine for Severe Dry Eye Disease in Liver-Transplanted Portuguese Patients with Familial Amyloidotic Polyneuropathy (ATTRV30M)
Authors: Beirão João M. , Matos Maria E. , Beirão Idalina B. , Costa Paulo P. , Torres Paulo A. 
Published: September 2012

Purpose. Evaluation of the use of topical cyclosporine eyedrops in the treatment of severe dry eye disease in liver transplanted patients with familial amyloidotic polyneuropathy (FAP) unresponsive to therapy with artificial tears and lacrimal plugs. Methods. A prospective clinical study of 5 patients (10 eyes) admitted to the Ophthalmology Department of the Centro Hospitalar do Porto with severe dry eye disease refractory to artificial tears and lacrimal plug treatments. Evaluation of the patients included best-corrected visual acuity, corneal punctuate fluorescein staining, tear break-up time, Schirmer test without anesthesia, and Ocular Surface Disease Index. Patients were observed at time 0, and at 3, 7, and 11 months. Results. Treatment with topical cyclosporine improved all studied parameters from baseline, and in all the patients (p<0.001). The safety profile was excellent, without topical or systemic adverse events. Conclusions. Topical cyclosporine was beneficial in the treatment of severe dry eye disease in liver transplanted patients with FAP.
TB DOTS-CHE KAP Baseline Survey in the Province of Antique
Authors: Mallorca Rezyl R. 
Published: September 2012

This paper is part of the overall baseline study assessing the knowledge, attitudes and care-seeking practices on Tuberculosis of the residents in the provinces of Antique, Cebu, Ilo-Ilo, Lanaodel Norte, Misamis Occidental and in the cities of Mandaluyong, Kidapawan and Surigao commissioned by Holistic Community Development and Initiatives, Inc. This is a descriptive research which used stratified random sampling in choosing the respondents per community with the aid of a map, totaling 2,435 residents. Since most of the covered community had no house maps, identifying respondents was also conducted with interviews using structured and centralized questionnaire prepared by the Philippine Business for Social Progress. Findings revealed that almost all residents heard about tuberculosis, knew that it is serious and contagious. However, results showed that despite respondents’ awareness on existence of tuberculosis, they lacked knowledge about its nature, cause, symptoms, preventions and treatment. Researchers also found out that attitudes of residents toward tuberculosis are positive though many feared mingling with TB infected individuals for possible contamination. With these, respondents need to be educated regarding tuberculosis’ prevention and treatment. Aggressive health education, enhanced programs for information dissemination and further assessment on TB DOTS program’s effectiveness are the ones recommended. Keywords - care seeking practices, tuberculosis, TB DOTS program
A Development of Knowledge Database Management System of Sufficiency Economy for Basic Education Principal
Authors: Nak Ai Nikom 
Published: September 2012

Knowledge database management system of sufficiency economy for basic education principal has been developed by Moodle, the open source of learning management system (LMS) and developed seventh step of the research cycles. Step 1: The need assessment for analyses element of sufficiency economy database for basic education and concentrate to school administration. Step 2 : The Product Design , the Researcher developed core of Database System by Moodle and consisted of; Assignment Module, Chat Module , Choice Module, Forum Module, Journal Module, Quiz Module, Resource Module, Survey Module, Workshop Module, Lesson Module, Glossary Module, WiKi Module and SCORM Module . Step 3 : Product Development , We used Moodle Version 9 to Designed login Menu and Registered Domain Name to Hosting , powered by LAMP, Integrated Application used of Linux , Apache server , MySql and PHP. Step 4: Preliminary Field Test and Initial Product Revision, the researchers to monitor and improve the quality of early found that the stability is satisfactory and reasonable speed. Step 5: Main Field Test and Step 6: Final Product Revision, Check the system with the primary goal found that the first web page (Homepage) modules will be even complete set. Step 7: Publishing database, Main target groups covered test system. Interesting name that is friendly and clearly defined in line with research. Result of the development of knowledge management issues under the principle of modesty, the validity Principle of immunity as well, Conditions of knowledge and integrity, applied to management of basic education for school administrators. Keyword - Knowledge Database Management System, Sufficiency Economy, Education Principal.
Correlation Between Subjective Well Being and Self-Esteem Levels of College Nursing Students
Authors: Avci Dilek , Yilmaz Figen Alp , Koç Ayşegül 
Published: September 2012

The study describes the relationship between subjective well-being and self-esteem levels of candidate nurses studying at the University of Balikesir and University of Bozok Colleges of Nursing. A total of 338 students enrolled at University of Balikesir, Bandirma College of Nursing and University of Bozok, College of Nursing formed the research sample tested under this study. Data were obtained by employing the “Personal Data Inquiry Form”, “Coopersmith Self- Esteem Inventory” and “Subjective Well-being Scale”. For the statistical evaluation of data, frequency distribution, t test, one-way analysis of variance and correlation coefficient were used. Of the participants 76.9% female and 23.1% male and the average age was 20.45 years. Most described their levels of income as average (80.2%) and family household relations as being at good levels (78.1%). The study revealed the presence of a positive significant relationship between subjective well-being and self-esteem levels of students. Furthermore, a significant relation was observed also between the subjective well-being and selfesteem levels of students by their perceived income levels and family relations. While a significant difference was observed between the subjective well-being and self-esteem scores by gender, no difference was found to exist between subjective well-being scores. At the end of the study, a significant relationship was found to exist between subjective well-being and self-esteem levels of nursing students. Keywords - Subjective well-being, self-esteem, nursing, university student
Adaptive tracking control for dynamic nonholonomic mobile robots with uncalibrated visual parameters
Authors: Yang Fang , Wang Chaoli , Jing Guangzhu 
Published: September 2012

SUMMARYThe trajectory tracking control problem of uncertain dynamic nonholonomic mobile robots is addressed in this paper. A novel uncertain camera‐object visual servoing kinematic tracking error model is proposed firstly. And then, on the basis of this model, a new adaptive torque tracking controller is presented in the presence of parametric uncertainties associated with the camera system and mechanical dynamic system. The controller synthesis is based on Lyapunov's direct method and backstepping technique. Simulation results are provided to illustrate the performance of the control law. Copyright © 2012 John Wiley & Sons, Ltd.
Carbon Nanotube Fiber Based Stretchable Conductor
Authors: Zu Mei , Li Qingwen , Wang Guojian , Byun Joon‐Hyung , Chou Tsu‐Wei 
Published: September 2012

AbstractCarbon nanotube (CNT) based continuous fiber, a CNT assembly that could potentially retain the superb properties of individual CNTs on a macroscopic scale, belongs to a fascinating new class of electronic materials with potential applications in electronics, sensing, and conducting wires. Here, the fabrication of CNT fiber based stretchable conductors by a simple prestraining‐then‐buckling approach is reported. To enhance the interfacial bonding between the fibers and the poly(dimethylsiloxane) (PDMS) substrate and thus facilitate the buckling formation, CNT fibers are first coated with a thin layer of liquid PDMS before being transferred to the prestrained substrate. The CNT fibers are deformed into massive buckles, resulting from the compressive force generated upon releasing the fiber/substrate assembly from prestrain. This buckling shape is quite different from the sinusoidal shape observed previously in otherwise analogous systems. Similar experiments performed on carbon fiber/PDMS composite film, on the other hand, result in extensive fiber fracture due to the higher fiber flexural modulus. Furthermore, the CNT fiber/PDMS composite film shows very little variation in resistance (≈1%) under multiple stretching‐and‐releasing cycles up to a prestrain level of 40%, indicating the outstanding stability and repeatability in performance as stretchable conductors.
Increased sphingoid base‐1‐phosphates and failure of neural tube closure after exposure to fumonisin or FTY720
Authors: Gelineau‐van Waes Janee , Rainey Mark A. , Maddox Joyce R. , Voss Kenneth A. , Sachs Andrew J. , Gardner Nicole M. , Wilberding Justin D. , Riley Ronald T. 
Published: September 2012

AbstractBACKGROUND: Fumonisin B1(FB1) is a mycotoxin produced by a common fungal contaminant of corn. Ingestion of FB1‐contaminated food is associated with increased risk for neural tube defects (NTDs). FB1induces NTDs in inbred LM/Bc mice. FB1inhibits ceramide synthase in de novo sphingolipid biosynthesis, resulting in accumulation of sphinganine and sphinganine‐1‐phosphate (Sa1P). Sa1P functions as a ligand for a family of G protein‐coupled S1P receptors.METHODS:Pregnant SWV and LM/Bc mice were treated with FB1(20 mg/kg/day intraperitoneally on embryonic day (ED) 7.5–8.5) or the known S1P receptor agonist FTY720 (10 mg/kg/day oral gavage on ED 6.5–8.5). LC/MS was used to detect sphingoid base‐1‐phosphates in maternal blood spots, plasma, and embryonic tissue. Strain‐specific SWV and LM/Bc mouse embryonic fibroblasts (MEFs) and serum free mouse embryo (SFME) neural progenitor cells were treated with FB1(40 μM for 24 hr) and LC/MS was used to detect sphingoid base‐1‐phosphates.RESULTS:FTY720 induced NTDs in both the SWV and the LM/Bc strains of mice. Sphinganine‐1‐P (Sa1P) and FTY720‐P were elevated in the blood spots and plasma of mice treated with FB1or FTY720, respectively. FTY720‐P was elevated in ED 9.5 exencephalic embryos. Sa1P was elevated in SFME and MEF cells treated with FB1, and Sa1P was higher in MEFs generated from the FB1‐NTD–susceptible LM/Bc strain.CONCLUSIONS:Elevated sphingoid base‐1‐P after FB1or FTY720 suggest a potential role for these bioactive lipid ligands and activation of S1P receptor signaling pathways in the failure of neural tube closure after FB1or FTY720. Sa1P may represent a biomarker for FB1‐NTD risk assessment. Birth Defects Research (Part A), 2012. © 2012 Wiley Periodicals, Inc.
Epithelial to mesenchymal transition as a portal to stem cell characters embedded in gene networks
Authors: Asli Naisana S. , Harvey Richard P. 
Published: September 2012

AbstractCells can transit between a range of stable epithelial and mesenchymal states and this has allowed the evolution of complex body forms. Epithelial to mesenchymal transition (EMT) and its reverse, mesenchymal to epithelial transition (MET), occur sequentially in development and organogenesis. EMT often accompanies transitions between stem‐like cells and their more differentiated progeny, as occurs at gastrulation, although the relevance of this had not been clarified. New findings from the cancer and cell reprogramming fields suggest that EMT and MET can act as essential portals to stem cell character. Here, we review these findings in the broader context of EMT and MET with emphasis on stem cell biology. Using the heart as an example, we also explore the potential role of EMT/MET in organ regeneration. Understanding EMT and MET at a network level will give us new tools to probe stem cell character and enhance tissue repair.
Synthesis of 3‐Fluoropyrrolidines and 4‐Fluoropyrrolidin‐2‐ones from Allylic Fluorides
Authors: Combettes Lorraine E. , Schuler Marie , Patel Rakesh , Bonillo Baltasar , Odell Barbara , Thompson Amber L. , Claridge Tim D. W. , Gouverneur Véronique 
Published: September 2012

AbstractVarious 3‐fluoropyrrolidines and 4‐fluoropyrrolidin‐2‐ones were prepared by 5‐exo‐trig iodocyclisation from allylic fluorides bearing a pending nitrogen nucleophile. These bench‐stable precursors were made accessible upon electrophilic fluorination of the corresponding allylsilanes. The presence of the allylic fluorine substituent induces syn‐stereocontrol upon iodocyclisation with diastereomeric ratios ranging from 10:1 to > 20:1 for all N‐tosyl‐3‐fluoropent‐4‐en‐1‐amines and amides. The sense and level of stereocontrol is strikingly similar to the corresponding iodocyclisation of structurally related allylic fluorides bearing pending oxygen nucleophiles. These results suggest that the syn selectivity observed upon ring closure involves I2–π complexes with the fluorine positioned inside.