bluuebunny/crossref_metadata_2025_split huggingface dataset:
What influences withdrawal because of rejection of telehealth – the whole systems demonstrator evaluation
Authors: Rixon Lorna , P. Hirani Shashivadan , Cartwright Martin , Beynon Michelle , Selva Abi , Sanders Caroline , P. Newman Stanton 
Published: November 2013

Purpose
– The widespread deployment of telehealth (TH) has been conducted in the absence of any clear understanding of how acceptable these devices are to patients. One potential limitation of the widespread deployment of TH is that patients may refuse. Moreover an understanding of the reasons for refusing to use TH devices will provide an understanding of the barriers.

Design/methodology/approach
– This investigation from the Whole Systems Demonstrator (WSD) programme, a pragmatic cluster randomised controlled trial into the effectiveness of TH, examined reasons for patients in the intervention cohort of the trial refusing TH, and the potential barriers to its deployment.

Findings
– Active rejection of the TH intervention was the most frequent reason for withdrawal. After examination of trial-related, health, socio-demographic, cognitive, emotional and behavioural factors, patients diagnosed with diabetes, as opposed to heart failure or chronic obstructive pulmonary disease, and patients’ beliefs about the acceptability of the intervention predicted whether or not they withdrew from the trial because of the intervention.

Originality/value
– Beliefs that the TH intervention resulted in increased accessibility to care, satisfaction with equipment and fewer concerns about the privacy, safety and discomfort associated with using TH equipment predicted continued participation in the WSD trial. Findings suggest that potentially modifiable beliefs about TH predict those more likely to reject the intervention. These findings have important implications for understanding individual differences in the acceptance of TH and subsequent success in mainstreaming TH in healthcare services.
Digital reablement – a personalised service to reduce admissions and readmissions to hospitals and nursing homes
Authors: Doughty Kevin , Mulvihill Patrick 
Published: November 2013

Purpose
– The purpose of this paper is to consider the importance of digital healthcare through telecare and portable assistive devices in supporting the reengineering of healthcare to deal with the needs of an older and more vulnerable population wishing to remain in their own homes.

Design/methodology/approach
– It supports the importance of the assessment process to identify hazards associated with independent living, and the possible consequences of accidents. By measuring and prioritising the risks, appropriate management strategies may be introduced to provide a safer home environment.

Findings
– A process for assessing and managing these risks has been developed. This can be applied to a wide range of different cases and yields solutions that can support independence.

Research limitations/implications
– The developed digital reablement process can be used to provide vulnerable people with a robust form of risk management.

Practical implications
– If telecare services follow the process described in this paper then they will improve the outcomes for their users.

Originality/value
– The process described in this paper is the first attempt to produce a robust assessment process for introducing telecare services in a reablement context.
Can smartphones support inclusion for autism in mainstream?
Authors: Mintz Joseph 
Published: November 2013

Purpose
– The “Helping Autism Diagnosed Navigate and Develop Socially” (HANDS) project developed a suite of mobile apps for smartphones, which support children with Autism spectrum disorders (ASD) with social and life skills functioning – areas of ability which tend to be impaired in this population. The apps were field tested in four special schools. The purpose of this paper is to report on an exploratory investigation of the potential use of this and similar technology to support the inclusion of children with ASD in mainstream secondary schools.

Design/methodology/approach
– A series of technology familiarization sessions and follow up focus groups were held with children with ASD, teachers, teaching assistants and parents at three mainstream secondary schools. A thematic analysis of the focus group transcripts was undertaken.

Findings
– The analysis indicated common themes across schools relating to challenges and opportunities in the use of smartphones to develop social and life skills. Wider debates in the available literature and the general media about national and local school policy on the use of smartphones in the classroom were reflected in the themes identified. Conclusions are drawn about the potential use of smartphones to promote inclusion of children with ASD, and recommendations are made in regards of national and local policy on the use of mobile technology in schools.

Originality/value
– There is little literature on the use of smartphones with children with ASD to support inclusion in mainstream. As such, this initial exploratory report will be of interest to policy makers, school managers and researchers.
Corporate real estate mirrors brand: a conceptual framework and practical applications
Authors: Khanna Chesta , J. M. van der Voordt Theo , W. Koppels Philip 
Published: November 2013

Purpose
– The purpose of this paper is to show how international companies (can) use real estate as a means to reinforce corporate identity and to express brand values in order to evoke a positive image in today's competitive world.

Design/methodology/approach
– A review of literature, seven case studies including analysis of company documents and in-depth interviews with marketing experts and real estate advisors, and a cross-case analysis showing the translation of brand core values in real estate strategies of these multinationals.

Findings
– The findings show that brand values are incorporated in the location strategy, building strategy, workplace strategy and at portfolio management level by all companies, but in different ways and with different focus points. Most commonly used brand values are “Green” values, i.e. sustainability, reliability, transparency, innovation and people oriented. Branding policies take into account both internal stakeholders such as the employees and external stakeholders such as customers and investors.

Research limitations/implications
– The number of interviews is rather small and limited to Dutch staff members of multinationals. Reliability of the findings was enforced by triangulation through connecting the interview findings to literature and strategic documents. Additional empirical research is needed to further explore which strategic choices can be made and in particular what are the actual costs and benefits of “branding by real estate”.

Practical implications
– The different ways to translate corporate brand values in real estate and the conceptual framework that has been developed to describe the step-by-step approach – from defining a vision to translating corporate culture and corporate identity into a well-considered real estate strategy – can be used by policy makers and real estate managers in real estate decision-making on strategic, tactical and operational level.

Originality/value
– The paper links findings from corporate real estate management with insights from marketing theory and adding value by real estate.
Creating business value with open space flexible offices
Authors: De Paoli Donatella , Arge Kirsten , Hunnes Blakstad Siri 
Published: November 2013

Purpose
– The purpose of this paper is to examine what organisational and management practices used in connection with open space flexible offices create business value. It seeks to identify what consequences this may have for successful real estate practices.

Design/methodology/approach
– This paper utilises an inductive case study approach. The international telecom company Telenor has implemented open space flexible offices from top to bottom amongst their 35,000 employees. The case description and analysis is based on secondary data, user evaluations and 20 interviews with middle- and top-level managers across levels and functional departments.

Findings
– The case of Telenor reveals that leadership and organizing issues are important, together with work modes and communication technology, for a productive use of work place design. The paper highlights specifically how the open, transparent, flexible office solution creates business value when used with centralised and standardised organisational management systems and a participative, informal leadership culture.

Research limitations/implications
– The study is based on one case, so the findings need to be tested across a representative sample of companies.

Practical implications
– Managers need to take both organisational and management issues into consideration when implementing new office space design. This challenges also the existing real estate strategies to include the organisational and management issues in their planning.

Originality/value
– The originality and value of the paper lies in the analysis and findings of the Telenor case introducing organizational and management perspectives to real estate issues.
Achieving plausible separability for the resolution of cross-border banks
Authors: Mayes David 
Published: November 2013

Purpose– This paper aims to consider whether it is plausible to resolve troubled systemically important cross-border banks by dividing them so that the component national authorities can resolve the parts in their jurisdiction separately according to their own priorities.Design/methodology/approach– The example of New Zealand is used. This country has chosen just such a route in its Open Bank Resolution (OBR) policy. The difficulties and advantages of this route to resolution are analyzed.Findings– The paper concludes that the New Zealand route is plausible for systemic subsidiaries, providing there is deposit insurance. The minimum cost route is likely to be one where the home authority takes responsibility for the whole group and keeps all systemic operations running. It remains to be seen what the new EU-level proposals could achieve.Research limitations/implications– OBR is as yet fortunately untried although there are some examples from a smaller scheme in Denmark.Practical implications– These findings have important implications for financial regulators round the world but especially in the EU as it seeks to find a similar approach in the Recovery and Resolution Directive.Originality/value– This topic has not been covered by others and will add ideas of practical value to the debate. One of the major problems addressed by the Basel Committee in its approach to supervision and regulation of cross-border banks is to come up with arrangements that allow the network of national authorities to handle problems in a large cross-border bank quickly, efficiently and preferably pre-emptively without recourse simply to a major taxpayer bailout.
Bank business models, capital rules and structural separation policies
Authors: Blundell-Wignall Adrian , Roulet Caroline 
Published: November 2013

Purpose
– The study examines the roles of capital rules, macro variables and bank business models in determining the safety of banks as measured by the “distance-to-default” (DTD) with the purpose of drawing implications for regulation of bank capital and business models.

Design/methodology/approach
– A panel regression study using pre- and post-crisis data for 108 US and European banks is used to explore the issue empirically. A new technique is also used to back out the amount of capital banks would have needed during the crisis to keep the “DTD” in the very safe zone.

Findings
– The simple leverage ratio has a strong relationship with “DTD”, while the Basel ratio does not. The most important business model features are derivatives and wholesale funding, which have a strong negative relationship with “DTD”. Trading and available-for-sale securities have a positive influence. Calculations show that it is not possible for any reasonable capital rule to compensate for the risks created by business model features encompassing large derivative-based activities. Bank separation policies are essential.

Originality/value
– The micro evidence-based analysis as an approach to bank regulation and business model requirements stands in contrast to the ad hoc way policy has been constructed before and after the crisis. The empirical evidence supports separation based on the balance sheet size of derivatives and a leverage ratio instead of the complex Basel risk-weighted capital approach. The current approaches to structural separation are criticised constructively, and some evidence-based suggestions for improving bank business models to reduce systemic risk are made.
The use of pseudorandom sweeps for vibroseis surveys
Authors: Dean T. 
Published: November 2013

ABSTRACTPseudorandom vibroseis sweeps have long been suggested as an alternative to standard linear sweeps due to their potential for having superior orthogonality, a lower likelihood for infrastructure damage, and increased low‐frequency content. In the past, they were also attractive as they have a better autocorrelation shape, although that is less important today. Their use has been limited but the increasing popularity of simultaneous acquisition techniques has rekindled interest as they offer the ability to reduce interference noise. A wide variety of methods for generating pseudorandom sweeps have been developed over the last 45 years. This paper gives an overview of the motivations for their use before classifying and describing the different sweep types. Finally, the sweeps will be compared in terms of their major attributes including their suitability for simultaneous surveys.
The influence of past experience on wasp choice related to foraging behavior
Authors: Sabrina Moreyra , D'Adamo Paola , Lozada Mariana 
Published: November 2013

AbstractMemory has been little studied in social wasps. Vespula germanica (Fab.) (Hymenoptera: Vespidae) frequently revisits nondepleted food sources, making several trips between the resource and the nest. In this study, we analyzed this relocating behavior in order to evaluate whether this species is capable of remembering an established association after 1 h. To this end, we trained wasps to feed from a certain array. Then it was removed, setting it up again 1 h later, but this time 2 baited feeders were put in place, one at the original feeding site and the other opposite the first. We recorded the proportion of returning foragers, and their choice of feeder, after either 1 or 4 feeding trials. After 1 h, 78% of wasps trained with 4 feeding trials and 65% trained with 1, returned to the experimental area. Furthermore, during the testing phase, wasps trained with 4 feeding trials collected food from the previously learned feeder significantly more frequently than from the nonlearned one (P < 0.05). In contrast, wasps that had been trained only once chose both feeders equally. Thus, memory retrieval could be observed 1 h after wasps had collected food on 4 consecutive occasions, but not after only 1. To our knowledge, this is the first study showing that V. germanica is capable of remembering an association 1 h after the last associative event, demonstrating that 1 h does not impair memory retention if 4 feeding experiences have occurred.
Serum Levels of Intact Parathyroid Hormone Is a Prognostic Indicator of Dialyzed Patients: The Nishinomiya Study
Authors: Hasuike Yukiko , Oue Mai , Hamahata Sayuri , Kimura Tomoko , Fukao Wataru , Mizusaki Kosuke , Kaibe Shoji , Nagasawa Yasuyuki , Kuragano Takahiro , Nakanishi Takeshi 
Published: November 2013

AbstractPatients with chronic kidney disease on dialysis are at higher risk for cardiovascular disease (CVD), which is the greatest cause of mortality. The target range of serum intact parathyroid hormone (iPTH) for prognosis, 60 to 240 pg/mL, was recommended by the Japanese Society for Dialysis Therapy guidelines. To investigate the impact of this iPTH target on CVD, dialysis patients were enrolled. A total 287 participants were observed. At the start of the study, serum iPTH levels, routine laboratory parameters, and certain factors related to CVD were evaluated. A survival analysis (Kaplan–Meier curve) was used. After 10 years of follow‐up, 19.2% of patients had CVD. The subjects were divided into three groups according to their iPTH level at baseline based on the target range of 60 to 240 pg/mL: Low, Middle, and High groups. CVD was more common in the High and Low groups compared to the Middle group. A lower risk of CVD was evident in the extended dialysis patients with a range of 60 to 240 pg/mL iPTH. Further studies are needed to evaluate the impact of the iPTH level on poor outcome.
The epidemiology of food allergy in Europe: a systematic review and meta‐analysis
Authors: Nwaru B. I. , Hickstein L. , Panesar S. S. , Muraro A. , Werfel T. , Cardona V. , Dubois A. E. J. , Halken S. , Hoffmann‐Sommergruber K. , Poulsen L. K. , Roberts G. , Van Ree R. , Vlieg‐Boerstra B. J. , Sheikh A. ,   the EAACI Food Allergy and Anaphylaxis Guidelines Group
Published: November 2013

AbstractFood allergy (FA) is an important atopic disease although its precise burden is unclear. This systematic review aimed to provide recent, up‐to‐date data on the incidence, prevalence, time trends, and risk and prognostic factors for FA in Europe. We searched four electronic databases, covering studies published from 1 January 2000 to 30 September 2012. Two independent reviewers appraised the studies and qualified the risk of bias using the Critical Appraisal Skills Programme tool. Seventy‐five eligible articles (comprising 56 primary studies) were included in a narrative synthesis, and 30 studies in a random‐effects meta‐analysis. Most of the studies were graded as at moderate risk of bias. The pooled lifetime and point prevalence of self‐reported FA were 17.3% (95% CI: 17.0–17.6) and 5.9% (95% CI: 5.7–6.1), respectively. The point prevalence of sensitization to ≥1 food as assessed by specific IgE was 10.1% (95% CI: 9.4–10.8) and skin prick test 2.7% (95% CI: 2.4–3.0), food challenge positivity 0.9% (95% CI: 0.8–1.1). While the incidence of FA appeared stable over time, there was some evidence that the prevalence may be increasing. There were no consistent risk or prognostic factors for the development or resolution of FA identified, but sex, age, country of residence, familial atopic history, and the presence of other allergic diseases seem to be important. Food allergy is a significant clinical problem in Europe. The evidence base in this area would benefit from additional studies using standardized, rigorous methodology; data are particularly required from Eastern and Southern Europe.
Serum vitamin E concentrations at 1 year and risk of atopy, atopic dermatitis, wheezing, and asthma in childhood: the PASTURE study
Authors: Nwaru B. I. , Virtanen S. M. , Alfthan G. , Karvonen A. M. , Genuneit J. , Lauener R. P. , Dalphin J.‐C. , Hyvärinen A. , Pfefferle P. , Riedler J. , Weber J. , Roduit C. , Kaulek V. , Braun‐Fahrländer C. , von Mutius E. , Pekkanen J. ,   the PASTURE study group
Published: November 2013

AbstractBackgroundProspective studies investigating the role of serum vitamin E concentrations during early life in the development of childhood allergies and asthma are limited.ObjectiveTo study the associations between serum vitamin E concentrations at first year of life and longitudinal development of atopy, atopic dermatitis, wheeze, and asthma up to 6 years of age.MethodsThe setting was the PASTURE study, a multicenter prospective birth cohort study in five European rural settings. Children of 1133 mothers recruited during pregnancy were followed from birth with measurement of serum vitamin E levels at year 1 and repeated assessments of serum immunoglobulin E antibodies (year 1, 4.5, 6), atopic dermatitis, wheezing symptoms, and asthma (year 1, 1.5, 2, 3, 4, 5, 6).ResultsAt 6 years of age, 66% and 82% of the original 1133 subjects underwent blood test for IgE and answered the questionnaire, respectively. We did not observe any statistically significant associations between serum vitamin E concentrations at year 1 and the endpoints, but borderline inverse associations between alpha tocopherol and wheezing without cold (OR 0.45, 95% CI 0.19–1.09) and any wheezing symptom (OR 0.52, 95% CI 0.27–1.02).ConclusionsSerum vitamin E concentrations at year 1 were not associated with allergies or asthma by 6 years of age. While further prospective studies with repeated assessments of vitamin E during early life may clarify its putative role in the development of the diseases, it is also possible that the antioxidant hypothesis in the development of allergies and asthma does not hold.
A Receptor‐Based Bioadsorbent to Target Advanced Glycation End Products in Chronic Kidney Disease
Authors: Zhang Yangrong , Lapidos Karen A. , Gal‐Moscovici Anca , Sprague Stuart M. , Ameer Guillermo A. 
Published: November 2013

AbstractThe accumulation of advanced glycation end products (AGEs) has been reported to be a major contributor to chronic systemic inflammation. AGEs are not efficiently removed by hemodialysis or the kidney of a chronic kidney disease (CKD) patient. The goal of this study was to develop a receptor for AGEs (RAGE)‐based bioadsorbent device that was capable of removing endogenous AGEs from human blood. The extracellular domain of RAGE was immobilized onto agarose beads to generate the bioadsorbent. The efficacy of AGE removal from saline, serum, and whole blood; biological effects of AGE reduction; and hemocompatibility and stability of the bioadsorbent were investigated. The bioadsorbent bound AGE‐modified bovine serum albumin (AGE‐BSA) with a binding capacity of 0.73 ± 0.07 mg AGE‐BSA/mL bioadsorbent. The bioadsorbent significantly reduced the concentration of total AGEs in serum isolated from end‐stage kidney disease patients by 57%. AGE removal resulted in a significant reduction of vascular cell adhesion molecule‐1 expression in human endothelial cells and abolishment of osteoclast formation in osteoclast progenitor cells. A hollow fiber device loaded with bioadsorbent‐reduced endogenous AGEs from recirculated blood to 36% of baseline levels with no significant changes in total protein or albumin concentration. The bioadsorbent maintained AGE‐specific binding capacity after freeze‐drying and storage for 1 year. This approach provides the foundation for further development of soluble RAGE‐based extracorporeal therapies to selectively deplete serum AGEs from human blood and decrease inflammation in patients with diabetes and/or CKD.
Basic characterization of avian NK‐lysin (NKL) from the Japanese quail, Coturnix japonica
Authors: Ishige Taichiro , Hara Hiromi , Hirano Takashi , Kono Tomohiro , Hanzawa Kei 
Published: November 2013

AbstractWe identified an antimicrobial cationic peptide that was expressed in the natural killer cells and cytotoxic T‐lymphocytes of Japanese quail. The gene, designated CjNKL, was located downstream of AEBP1L and POLD2 in a region syntenic with the chicken genome. CjNKL comprised four exons, as does chicken GgNKL. The coding sequence in CjNKL was 411 bp long and exon 3 of CjNKL lacked 9 bp when compared to chicken GgNKL, but CjNKL and GgNKL were 81% identical at the nucleic acid level. The saposin like type‐B domain of CjNKL contained the six essential cysteines, one proline, 15 cationic amino acids residues, and an antibacterial region that are characteristic of NKL proteins. The 5' flanking region of CjNKL contained positive regulatory elements, an activator protein‐1 binding site and two nuclear factor (NF)‐κB binding sites, and a negative regulatory element, CAAT/enhancer binding protein β (C/EBPβ) binding site. However, the number of NF‐κB sites and C/EBPβ sites within CjNKL are fewer than the number within GgNKL. Additionally, we confirmed that CjNKL was transcribed in at least 18 tissues, including immune and digestive tissues. These data indicated that transcriptional activation of CjNKL differed slightly from those of GgNKL.