bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum Sodium Status in Children with Simple and Complex Febrile Seizure: A Comparative Hospital Based Study
Authors: Shil Sunanda , Datta Mitra , Barua Dazy , Jahan Rifat , Shil Prashanta Kumar , Das Aparup Kanti , Chakraborty Rivu Raj 
Published: August 2024

Background: Fever is the most common cause of convulsions, in infancy and childhood. Complex febrile seizures are associated with an increased risk of subsequent epilepsy. The present study aimed to evaluate the role of serum sodium levels and associated factors in children with simple and complex febrile seizures admitted to a tertiary level hospital in Bangladesh.
Materials and methods: Children aged between 6 months to 60 months with febrile seizures, admitted to the Paediatric ward of Chittagong Medical College Hospital, Chattogram, were recruited in the study. Serum sodium level at admission were estimated and patients were categorized into two group: simple and complex febrile seizure. Data were analyzed by comparing different variables between two groups.
Results: A total of 60 children were enrolled in the study in which 36 were diagnosed with simple febrile seizures and 24 of them with complex febrile seizures. The mean age was 22.3 months and there was male preponderance with a male to female ratio of 2.3:1. The mean serum sodium level was 136.9±6.5 mmol/l and 18 (30%) patients had hyponatremia. Serum sodium levels were significantly lower in children with complex febrile seizure (134.0±6.1 and 138.9 ± 6.0, p=0.003) than the children with simple seizure. The optimal cutoff value of serum sodium level was 134 mmol/L with an area under the receiver operating characteristic curve of 0.723 (95% CI: 0.590-0.856), with sensitivity of 80.0% and specificity of 50.0%.
Conclusions: Our study suggested that serum sodium levels were significantly lower in children with complex febrile seizures. However, because of its lower specificity value, further studies are needed to confirm the utility of serum sodium level in childhood febrile seizure.
IAHS Medical Journal Volume 6(1) June 2023; 34-38
OPTIMASI MORINGA GUM DAN POLIVINIL ALKOHOL DALAM SEDIAAN MUCOADHESIVE BUCCAL FILM DILTIAZEM HIDROKLORIDA
Authors: Nani Sukmawati  , Lusia Oktora Ruma Kumala Sari  , Eka Deddy Irawan  
Published: August 2024

Abstract. Diltiazem Hydrochloride (HCl) is commonly used in hypertension therapy for its beneficial effects, such as reducing blood vessel pressure resistance and relaxing the heart muscles. In an in-vivo study, Diltiazem HCl is known to be decrease by 60% of its bioavailability due to first-pass metabolism. Thus, it is necessary to develop a new administration route, some of which is buccal drug delivery route in mucoadhesive buccal film. Moringa gum is a polyuronide polymer with a hydroxyl group in its side chains, giving the potential use as a mucoadhesive polymer. However, it has poor folding endurance and its release kinetics study has not been investigated. Polyvinyl alcohol (PVA) is a water-soluble polymer with hydroxyl side chain. PVA is known for its high tensile strength and flexibility, though it can be affected by humidity. The aim of this research is to determine the right amount of moringa gum and PVA to obtain a film with good physical characteristics and mucoadhesive residence time. In this study, the optimization of moringa gum and PVA was carried out using factorial design. Mucoadhesive buccal film was prepared by solvent casting method, the films were later evaluated and the obtained responses were analyzed by Software Design Expert 11.0.0. The optimization result shows the film containing the amount of moringa gum 2% and PVA 5% can produce the optimum formula. The mucoadhesive buccal film formula has surface pH of 6.083, mucoadhesive residence time of 445.055 min, swelling index of 4.067, and 87.9913% drug release in in-vitro drug release study after 420 min following the Higuchi model release kinetics. Therefore, it can be concluded that the obtained optimum formula of mucoadhesive buccal film can be used in the preparation of mucoadhesive buccal film Diltiazem HCl..
Kata Kunci:
Hypertension; Diltiazem HCl; Mucoadhesive buccal film; Moringa gum; PVA.
Pengendalian Tindakan Phubbing Anak: Studi Analisis Peran Orang Tua Dalam Pola Asuh Anak Sekolah Dasar
Authors: Hidayat Wahyu 
Published: August 2024

The purpose of this study is to explain the importance of the role of parents in controlling children's phubbing actions, as well as familiarizing children in using smartphones wisely. This type of research is field research with descriptive approach. The subjects in this study included parents who had early childhood and elementary school with a total of 12 people (5 Male, 7 Female). There are two data collection techniques conducted by researchers, namely (1) observation techniques, (2) interviews. Data testing techniques to verify the validity of data in this study include extension of participation, persistence of observation, and triangulation of methods. The results of the research showed that parents complain about the lack of communication with their children when their children use gadgets and many children do not care about their parents' calls when using gadgets. Solutions to research problems, the role of parents in supervising and accompanying children in the use of gadgets, as follows: 1) parents need to set a time limit when using technology to work or enjoy entertainment, and do not violate it, 2) parents accompany the child when using gadgets, 3) balance smartphone users with other activities, such as playing outdoors, 4) set smartphone rules (length of use and visible content), 5) parents as suri tauladan their children, as well as explaining content that should not be seen and accessed.
Analisis Perceraian Berdasarkan Perspektif Gender Pada Wanita Karir (Studi Kasus Di Kecamatan Pabuaran Kabupaten Serang)
Authors: Robiatussoleha Ratu Aulia , Hapid TA Ahmad , Afrizal Stevany 
Published: August 2024

Perceraian merupakan fenomena yang telah menjadi isu penting dalam masyarakat modern. Peningkatan jumlah perceraian telah menjadi perhatian khusus, terutama dalam konteks wanita karir yang menghadapi tantangan dalam menyeimbangkan peran profesional dan keluarga. Dimana ada beberapa masalah yang terjadi dalam kehidupan pasangan suami istri salah satunya yaitu faktor ekonomi juga dapat mempengaruhi keputusan perceraian pada wanita karir. Pada angka perceraian yang tinggi juga dapat mencerminkan adanya ketidaksetaraan dan diskriminasi gender dalam institusi pernikahan. Meskipun perempuan memiliki kemandirian ekonomi dan karir, mereka masih menghadapi beban ganda dalam mengelola tanggung jawab domestik dan profesional. Kondisi ini dapat memicu konflik dan ketegangan dalam rumah tangga, yang pada akhirnya mendorong perceraian. Penelitian ini akan menggunakan metode kualitatif untuk memperoleh pemahaman yang detail tentang pengalaman perceraian wanita karir dari perspektif gender. Penelitian ini juga menggunakan Teori feminisme liberal menegaskan bahwa perempuan dan laki-laki diciptakan secara setara, memiliki hak yang sama, dan harus memiliki peluang yang sama. Ini juga berlaku dalam dunia kerja, di mana perempuan juga harus diberikan kesempatan agar dapat berkarir sesuai dengan apa yang ia inginkan.
Konsep Diri Fujoshi Penggemar Boys Love Thailand pada Mahasiswi Fakultas Keguruan
Authors: Hidayah Siti Ismi Nurul , Setiawan Rizki , Haryono Haryono 
Published: August 2024

Boys love adalah genre hiburan yang populer di kalangan anak muda, menggambarkan hubungan romantis antara dua laki-laki. Mahasiswi keguruan juga menikmati genre ini. Penelitian ini bertujuan mendeskripsikan konsep diri fujoshi pada mahasiswi keguruan yang menggemari serial boys love Thailand. Penelitian menggunakan metode kualitatif dengan pendekatan studi kasus. Subjek penelitian adalah tujuh mahasiswi fakultas keguruan yang menikmati konten boys love, dipilih dengan teknik purposive sampling. Data dikumpulkan melalui wawancara mendalam, observasi, dan dokumentasi. Analisis dilakukan menggunakan konsep dari buku "Transformation of Intimacy" oleh Anthony Giddens. Hasil penelitian menunjukkan bahwa fujoshi menonton boys love karena tertarik dengan genre yang baru, plot cerita yang menarik, dan ketampanan aktor. Penelitian ini mengungkap bagaimana mereka menyembunyikan minat terhadap serial boys love Thailand sebagai respons terhadap regulasi pemerintah terhadap LGBT dan norma sosial. Fujoshi mengonsumsi tayangan boys love untuk kesenangan pribadi dan fantasi, serta sebagai hiburan di tengah kesibukan perkuliahan. Sebagai mahasiswi fakultas keguruan mereka memahami norma masyarakat, kelak saat menjadi guru akan berkomitmen menjaga profesionalitas dengan memisahkan antara hobi dan pekerjaan.
PERIZINAN EKSPOR SATWA LIAR YANG TIDAK DILINDUNGI UNDANG-UNDANG DENGAN IMPLEMENTASI CITES DI INDONESIA
Authors: Nurfadjri Annisa , Zahidi M. Syaprin 
Published: August 2024

Artikel ini merupakan hasil penelitian yang membahas perizinan ekspor satwa liar yang tidak dilindungi Undang-Undang dengan implementasi CITES di Indonesia. CITES merupakan konvensi perdagangan internasional yang mengatur tentang spesies flora dan fauna yang terancam punah. Melimpahnya sumber daya alam hayati dan ekosistem Indonesia telah menimbulkan permasalahan terkait perdagangan satwa secara ilegal yang mengancam kelangsungan hidup satwa liar yang berada pada daftar terancam punah. Penelitian ini akan memberikan pemahaman secara lebih jelas tentang bagaimana sistem perizinan ekspor satwa liar yang tidak dilindungi Undang-Undang dan implementasi CITES di Indonesia. Metode yang digunakan dalam penelitian ini yaitu metode kualitatif deskriptif. Pemerintah Indonesia dalam meminimalisir perdagangan ilegal dan perburuan satwa langka berupaya menetapkan perizinan ekspor satwa liar yang tidak dilindungi Undang-Undang dan termasuk dalam daftar CITES yang diatur melalui Permendag 19 tahun 2021 Jo. 12 Tahun 2022. Dalam mengatur perdagangan satwa liar yang terancam punah pemerintah Indonesia menerapkan sistem perizinan ekspor satwa liar yang tidak dilindungi Undang-Undang melalui implementasi CITES. Implementasi CITES di Indonesia memainkan peran penting dalam mengatur perizinan ekspor satwa liar yang tidak dilindungi undang-undang dengan memastikan bahwa ekspor yang dilakukan diawasi untuk mencegah eksploitasi berlebihan yang dapat mengancam populasi dan ekosistem spesies satwa liar. Hal tersebut dilakukan dengan upaya memonitoring izin resmi ekspor satwa liar yang termasuk dalam Appendix II dengan membatasi dikeluarkannya izin ekspor untuk menjaga spesies satwa liar. Adapun syarat perizinan kegiatan ekspor satwa liar yang tidak dilindungi Undang-Undang yaitu dengan memperhatikan asal usul spesies melalui persetujuan otoritas keilmuan dengan melampirkan bukti SATS-DN yang menunjukan legalitas asal usul spesies.

Kata kunci: CITES; Ekspor; Satwa Liar; Perizinan; PE-TASL
Application of DNA aptamers to block enterotoxigenic Escherichia coli toxicity in a Galleria mellonella larval model
Authors: Barros Maria Margarida , Castro Joana , Araújo Daniela , Oliveira Ricardo , Campos Ana Maria , Silva Sónia , Outor-Monteiro Divanildo , Almeida Carina 
Published: August 2024

Enterotoxigenic Escherichia coli (ETEC) is the major bacterial cause of diarrheal diseases in pigs, particularly at young ages, resulting in significant costs to swine farming. The pathogenicity of ETEC is largely dependent on the presence of fimbriae and the ability to produce toxins. Fimbriae are responsible for their initial adhesion to the intestinal epithelial cells, leading to the onset of infection. In particular, the F4 type (K88) fimbriae are often attributed to neonatal infections and have also been associated with post-weaning diarrheal infections. This disease is traditionally prevented or treated with antibiotics, but their use is being severely restricted due to the emergence of resistant bacteria and their impact on human health. Emerging approaches such as aptamers that target the F4-type fimbriae and block the initial ETEC adhesion are a promising alternative. The aim of this study is to assess the effectiveness of two aptamers, Apt31 and Apt37, in controlling ETEC infection in the G. mellonella in vivo model. Initially, the dissociation constant (KD) of each aptamer against ETEC was established using real-time quantitative PCR methodology. Subsequently, different concentrations of the aptamers were injected into Galleria mellonella to study their toxicity. Afterwards, the anti-ETEC potential of Apt31 and Apt37 was assessed in the larvae model. The determined KD was 81.79 nM (95% CI: 31.21–199.4 nM) and 50.71 nM (95% CI: 26.52–96.15 nM) for the Apt31 and Apt37, respectively, showing no statistical difference. No toxicity was observed in G. mellonella following injection with both aptamers at any concentration. However, the administration of Apt31 together with ETEC-F4+ in G. mellonella resulted in a significant improvement of approximately 30% in both larvae survival and health index compared to ETEC-F4+ alone. These findings suggest that aptamers have promising inhibitory effect against ETEC infections and pave the way for additional in vivo studies.
Development and validation of next-generation sequencing panel for personalized Helicobacter pylori eradication treatment targeting multiple species
Authors: Min Byung-Joo , Seo Myung-Eui , Bae Jung Ho , Kim Ji Won , Kim Ju Han 
Published: August 2024

IntroductionThe decreasing Helicobacter pylori eradication rate is primarily attributed to antibiotic resistance, and further exacerbated by uniform drug administration disregarding a host’s metabolic capability. Consequently, applying personalized treatment based on antibiotic resistance-associated variants and the host’s metabolic phenotype can potentially increase the eradication rate.MethodA custom next-generation sequencing panel for personalized H. pylori eradication treatment (NGS-PHET) was designed which targeted the regions for amoxicillin, clarithromycin, metronidazole, tetracycline, and levofloxacin-resistance in H. pylori and human proton-pump inhibitor (PPI) metabolism. The libraries were constructed following customized methods and sequenced simultaneously. The customized framework criteria, grounded in previously reported antibiotic resistance associated variants and the host’s PPI metabolism, was applied to the NGS-PHET results and suggested a personalized treatment for each subject, which was validated through each subject’s actual eradication outcome.ResultsBoth previously reported and novel variants were identified from H. pylori sequencing results. Concurrently, five CYP2C19 homozygous extensive metabolizers and three CYP3A4 intermediate metabolizers were identified. Among the total of 12 subjects, clarithromycin triple therapy was suggested for five subjects, bismuth quadruple therapy was suggested for six subjects, and rifabutin triple therapy was suggested for one subject by following the customized framework criteria. The treatment suggestion for nine of the 12 subjects was consistent with the treatment that each subject achieved eradication with.DiscussionApplying the methodology using the NGS-PHET and customized framework helps to perform eradication treatment quickly and effectively in most patients with antibiotic-resistant H. pylori strains, and is also useful in research to find novel antibiotic-resistance candidates.
Early prediction of the bactericidal and bacteriostatic effect of imipenem and doxycycline using tabletop scanning electron microscopy
Authors: Zmerli Omar , Hodzic Alma , Bellali Sara , Azar Eid , Bou Khalil Jacques 
Published: August 2024

IntroductionOur work aims at establishing a proof-of-concept for a method that allows the early prediction of the bactericidal and bacteriostatic effects of antibiotics on bacteria using scanning electron microscopy (SEM) as compared to traditional culture-based methods.MethodsWe tested these effects using Imipenem (bactericidal) and Doxycycline (bacteriostatic) with several strains of sensitive and resistant Escherichia coli. We developed a SEM-based predictive score based on three main criteria: Bacterial Density, Morphology/Ultrastructure, and Viability. We determined the results for each of these criteria using SEM micrographs taken with the TM4000Plus II-Tabletop-SEM (Hitachi, Japan) following an optimized, rapid, and automated acquisition and analysis protocol. We compared our method with the traditional culture colony counting gold standard method and classic definitions of the two effects. ResultsOur method revealed total agreement with the CFU method and classic definition by visualizing the effect of the antibiotic at 60 minutes and 120 minutes using SEM. DiscussionThis early prediction allows a rapid and early identification of the bactericidal and bacteriostatic effects as compared to culture that would take a minimum of 18 hours. This has several future applications in the development of SEM-automated assays coupled to machine learning models that identify the antibiotic effect and facilitate determination of bacterial susceptibility.
Triangulation of family perspectives on father-adolescent talk about sex and relationships
Authors: Grossman Jennifer M. , DiMarco Audrey J. , Richer Amanda M. 
Published: August 2024

IntroductionFather-adolescent talk about sex can protect adolescents from sexual risk behaviors. However, few studies explore how family members view fathers' talk with adolescents about sex and relationships. An understanding of how fathers, mothers, and adolescents view fathers' roles in talk with adolescents about sex and relationships can help to guide fathers' talk with adolescents and inform programs to provide targeted support for father-adolescent communication about sex and relationships.MethodsThis study investigates family perceptions of father-adolescent communication about sex and relationships by triangulating data from fathers, mothers, and adolescents using content analysis to conduct between-family analysis and within-family approaches with 15 families (n = 45 individuals) with high school-aged adolescents from across the U.S.ResultsAnalyses showed agreement on the importance of fathers' roles in family talk about sex. The findings showed shared recognition of the importance of fathers' roles in family talk about sex. Between-group analyses showed that fathers, mothers, and adolescents view fathers' roles as emotional supports and open communicators with their adolescents about sex and relationships and as educators and advisors for their adolescent children. Within-family analysis showed that families often agreed that there were gender differences in how fathers talked with their sons and daughters, but family members expressed different views on how adolescents' gender impacts father-adolescent communication about sexual topics.DiscussionThese findings may encourage fathers who are uncertain about the value of their roles in talking with their adolescent children about sex and relationships. They also highlight the importance of examining how fathers' messages to their adolescents about sex and relationships may continue to follow patterns of gender stereotypes. This is the first study to qualitatively triangulate perspectives of fathers, mothers, and adolescents on father-adolescent communication about sex and relationships. Since fathers are often less involved than mothers in parent-adolescent communication about sex and relationships, an understanding of how mothers and adolescents see fathers' roles and messages can help provide a pathway for fathers' engagement which works within a family system.
Effect of vocabulary learning strategies on students’ vocabulary knowledge achievement and motivation: the case of grade 11 high school students
Authors: Ayana Haimanot , Mereba Temesgen , Alemu Adege 
Published: August 2024

IntroductionVocabulary knowledge achievement is crucial for effective language learning. However, there is a gap in vocabulary knowledge achievement, particularly at the Seto High School in Ethiopia. This study addresses this gap by focusing on Grade 11 students and investigating the effect of vocabulary learning strategies on students’ vocabulary knowledge achievement and motivation.MethodsA quasi-experimental design was employed, involving two natural classes of Grade 11 students, with 30 students in the experimental group and 30 in the control group, selected through convenience sampling. A mixed-method research design was also used to gather comprehensive data. The data collected included pretest and posttest assessments of vocabulary knowledge achievement, a vocabulary learning strategies (VLS) questionnaire, and semi structured interviews. The analysis of the data utilized statistical methods such as means, standard deviations, independent t - tests, and correlations to evaluate the effects of vocabulary learning strategies on students’ vocabulary knowledge achievement and motivation.ResultsHigh reliability was observed for both the VLS questionnaire and the tests. Pretest results revealed no significant (p &gt; 0.05) difference in vocabulary knowledge achievement between the experimental and control groups. Posttest results demonstrated a statistically significant (p &lt; 0.05) improvement in vocabulary achievement in the experimental group compared to the control group. Correlation analysis revealed a positive and significant (p &lt; 0.05) association between VLS use and vocabulary knowledge achievement. Survey results and qualitative data showed that students predominantly relied on dictionary-based vocabulary, saying the new word aloud, using the vocabulary section in textbook, and continuing to study words over time vocabulary learning strategies before training, with a noticeable shift toward increased use of guessing, keyword, and semantic mapping strategies after training. These findings underscore the effectiveness of VLS training in enhancing vocabulary knowledge among Grade 11 students. Finally, some recommendations are proposed.ConclusionThe study concluded that training in vocabulary learning strategies had a significant impact on students’ vocabulary knowledge achievement.
Effect of paternal age on clinical outcomes of in vitro fertilization-embryo transfer cycles
Authors: Gao Xinyan , Li Xiao , Wang Fanfan , Cai Wen , Sun Shihu , Lu Shaoming 
Published: August 2024

PurposeThis study aimed to investigate the impact of paternal age &gt; 40 years on clinical pregnancy and perinatal outcomes among patients undergoing in vitro fertilization treatment.MethodsWe selected 75 male patients (aged &gt; 40 years) based on predefined inclusion and exclusion criteria. Propensity score matching was performed in a 1:3 ratio, resulting in a control group (aged ≤ 40 years) of 225 individuals. Various statistical tests, including the Mann-Whitney U test, Chi-square test, Fisher’s exact test, and binary logistic regression, were used to analyze the association between paternal age and clinical outcomes.ResultsWe found no statistically significant differences in semen routine parameters, clinical pregnancy outcomes, and perinatal outcomes between paternal aged &gt; 40 and ≤ 40 years. However, in the subgroup analysis, the live birth rate significantly decreased in those aged ≥ 45 compared to those aged 41–42 and 43–44 years (31.25% vs. 69.23% and 65%, respectively; all p &lt; 0.05). Additionally, the clinical pregnancy rate was significantly lower among those aged ≥ 45 than among those aged 41–42 (43.75% vs. 74.36%; p=0.035).ConclusionPaternal age ≥ 45 years was associated with lower live birth and clinical pregnancy rates.