bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plantwise knowledge bank: delivering plant health information to developing country users
Authors: LEACH Margo C. , HOBBS Shaun L.A. 
Published: June 2013

ABSTRACTThe Plantwise knowledge bank is an open access, online resource that provides information to users involved in plant health systems in the developing world. The challenge was to deliver dependable information that could serve users with widely differing needs and understanding and to get actionable knowledge to subsistence farmers in particular. This was met by bringing together resources across CABI, particularly by supplementing core publishing capabilities with the knowledge, skills and understanding of the internationally based scientific staff and their network of collaborators. An iterative development process, with scoping, wireframes and prototype delivery, was undertaken with constant feedback from global users. Content needed to be repurposed from CABI's own databases, brought in from international partners and freshly created, and then delivered to each user in a structure that was easy to navigate and had easy‐to‐use tools to add value. The product has been widely well received and ongoing development will be guided by lessons learned and new requirements as the Plantwise programme expands.
Using Genome Query Language to uncover genetic variation
Authors: Kozanitis Christos , Heiberg Andrew , Varghese George , Bafna Vineet 
Published: June 2013

Abstract
Motivation: With high-throughput DNA sequencing costs dropping &lt;$1000 for human genomes, data storage, retrieval and analysis are the major bottlenecks in biological studies. To address the large-data challenges, we advocate a clean separation between the evidence collection and the inference in variant calling. We define and implement a Genome Query Language (GQL) that allows for the rapid collection of evidence needed for calling variants.
Results: We provide a number of cases to showcase the use of GQL for complex evidence collection, such as the evidence for large structural variations. Specifically, typical GQL queries can be written in 5–10 lines of high-level code and search large datasets (100 GB) in minutes. We also demonstrate its complementarity with other variant calling tools. Popular variant calling tools can achieve one order of magnitude speed-up by using GQL to retrieve evidence. Finally, we show how GQL can be used to query and compare multiple datasets. By separating the evidence and inference for variant calling, it frees all variant detection tools from the data intensive evidence collection and focuses on statistical inference.
Availability: GQL can be downloaded from http://cseweb.ucsd.edu/~ckozanit/gql.
Contact: ckozanit@ucsd.edu or vbafna@cs.ucsd.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Epigenetic Regulation of Spinal CXCR2 Signaling in Incisional Hypersensitivity in Mice
Authors: Sun Yuan , Sahbaie Peyman , Liang De-Yong , Li Wen-Wu , Li Xiang-Qi , Shi Xiao-You , Clark J. David 
Published: June 2013

Abstract

Background:
The regulation of gene expression in nociceptive pathways contributes to the induction and maintenance of pain sensitization. Histone acetylation is a key epigenetic mechanism controlling chromatin structure and gene expression. Chemokine CC motif receptor 2 (CXCR2) is a proinflammatory receptor implicated in neuropathic and inflammatory pain and is known to be regulated by histone acetylation in some settings. The authors sought to investigate the role of histone acetylation on spinal CXCR2 signaling after incision.

Methods:
Groups of 5–8 mice underwent hind paw incision. Suberoylanilide hydroxamic acid and anacardic acid were used to inhibit histone deacetylase and histone acetyltransferase, respectively. Behavioral measures of thermal and mechanical sensitization as well as hyperalgesic priming were used. Both message RNA quantification and chromatin immunoprecipitation analysis were used to study the regulation of CXCR2 and ligand expression. Finally, the selective CXCR2 antagonist SB225002 was administered intrathecally to reveal the function of spinal CXCR2 receptors after hind paw incision.

Results:
Suberoylanilide hydroxamic acid significantly exacerbated mechanical sensitization after incision. Conversely, anacardic acid reduced incisional sensitization and also attenuated incision-induced hyperalgesic priming. Overall, acetylated histone H3 at lysine 9 was increased in spinal cord tissues after incision, and enhanced association of acetylated histone H3 at lysine 9 with the promoter regions of CXCR2 and keratinocyte-derived chemokine (CXCL1) was observed as well. Blocking CXCR2 reversed mechanical hypersensitivity after hind paw incision.

Conclusions:
Histone modification is an important epigenetic mechanism regulating incision-induced nociceptive sensitization. The spinal CXCR2 signaling pathway is one epigenetically regulated pathway controlling early and latent sensitization after incision.
Does Goal-directed Fluid Therapy Affect Postoperative Orthostatic Intolerance?
Authors: Bundgaard-Nielsen Morten , Jans Øivind , Müller Rasmus G. , Korshin André , Ruhnau Birgitte , Bie Peter , Secher Niels H. , Kehlet Henrik 
Published: June 2013

Abstract

Background:
Early mobilization is important for postoperative recovery but is limited by orthostatic intolerance (OI) with a prevalence of 50% 6 h after major surgery. The pathophysiology of postoperative OI is assumed to include hypovolemia besides dysregulation of vasomotor tone. Stroke volume–guided fluid therapy, so-called goal-directed therapy (GDT), corrects functional hypovolemia, and the authors hypothesized that GDT reduces the prevalence of OI after major surgery and assessed this in a prospective, double-blinded trial.

Methods:
Forty-two patients scheduled for open radical prostatectomy were randomized into standard fluid therapy (control group) or GDT groups. Both groups received a fixed-volume crystalloid regimen supplemented with 1:1 replacement of blood loss with colloid, and in addition, the GDT group received colloid to obtain a maximal stroke volume (esophageal Doppler). The primary outcome was the prevalence of OI assessed with a standardized mobilization protocol before and 6 h after surgery. Hemodynamic and hormonal orthostatic responses were evaluated.

Results:
Twelve (57%) versus 15 (71%) patients in the control and GDT groups (P = 0.33), respectively, demonstrated OI after surgery, group difference 14% (CI, −18 to 45%). Patients in the GDT group received more colloid during surgery (1,758 vs. 1,057 ml; P = 0.001) and reached a higher stroke volume (102 vs. 89 ml; P = 0.04). OI patients had an increased length of hospital stay (3 vs. 2 days; P = 0.02) and impaired hemodynamic and norepinephrine responses on mobilization.

Conclusion:
GDT did not reduce the prevalence of OI, and patients with OI demonstrated impaired cardiovascular and hormonal responses to mobilization.
Endoscopic Retrograde Cholangiopancreatography in the Pediatric Population Is Safe and Efficacious
Authors: Enestvedt Brintha K. , Tofani Christina , Lee Dale Y. , Abraham Maíre , Shah Pari , Chandrasekhara Vinay , Ginsberg Gregory G. , Long William , Ahmad Nuzhat , Jaffe David L. , Mamula Petar , Kochman Michael L. 
Published: June 2013

ABSTRACTBackground:Endoscopic retrograde cholangiopancreatography (ERCP) is increasingly being used in the evaluation and management of biliary and pancreatic disorders in children. The aim of this study was to review the pediatric ERCP experience of a large academic referral center affiliated with a tertiary care children's hospital.Methods:This is a retrospective review of medical records, endoscopic and operative reports, and radiography of those patients ages 0 to 21 years who underwent ERCP for any indication between 1993 and 2011 at a tertiary referral center affiliated with a large urban pediatric hospital. ERCP technical success was defined as cannulation of the desired duct. Serious adverse events included bleeding, perforation, pancreatitis, or death.Results:Four hundred twenty‐nine ERCPs were performed on 296 patients. The mean age was 14.9 ± 4.8 years (3 months–21 years); 51.1% were boys. Patients with a history of previous liver transplant comprised 13.1% (56) of all ERCPs. Abnormal liver chemistries or suspected choledocholithiasis accounted for half of the indications. A therapeutic intervention was performed in 64.1%. Technical success was achieved in 95.2% of ERCPs. Serious adverse events occurred in 7.7%.Conclusions:Pediatric ERCP is highly efficacious in the pediatric population, with the rates of technical success and use of therapeutic interventions mirroring those in adults. There is a low overall rate of serious adverse events. The overall efficacy and safety support the performance of pediatric ERCP by experienced endoscopists at high‐volume centers.
Tribological behaviors of novel crown‐type phosphate ionic liquids as lubricants for steel/aluminum contacts
Authors: Jiang Dong , Hu Litian , Feng Dapeng 
Published: June 2013

PurposeThe purpose of this paper is to synthesize a novel kind of crown‐type phosphate ionic liquids with better tribological properties for steel/Al system. The anions of crown‐type phosphate ionic liquids contain no F element, which are non‐corrosive to metal.Design/methodology/approachTo improve the tribological properties of ionic liquid lubricants for the extremely difficult system of the steel‐against‐aluminum metal couple, novel crown‐type phosphate ionic liquids were prepared. The tribological properties of the crown‐type phosphate ionic liquids were evaluated at different loads and frequencies on an Optical SRV oscillating friction and wear tester. The morphology and chemical compounds of the wear scars were investigated by scanning electron microscope (SEM) and X‐ray photoelectron spectroscopy (XPS).FindingsCompared with conventional ionic liquids, the novel crown‐type phosphate ionic liquids prepared in the present work exhibit a more excellent anti‐wear ability for steel/Al2024 contact at different loads and frequencies. By the morphological analysis with SEM, less debris was observed in the worn surface lubricated with crown‐type phosphate ionic liquids, though more debris was observed when lubricated with LB106 and LP106. By the XPS analysis, boundary lubrication film composed of aluminum (III) oxide, organometallic compounds, and silicon aluminum phosphate were found in the worn surface. Namely, the tribological behaviors of the crown‐type phosphate ionic liquids could be attributed to their stronger adsorption and tribochemical interactions with the Al alloys.Research limitations/implicationsBecause of the higher mean friction coefficients of crown‐type phosphate ionic liquids in the research, researchers are encouraged to modify their structure for better tribological properties.Practical implicationsThe crown‐type phosphate ionic liquid exhibited better anti‐wear performance for steel/aluminum contact than the conventional ionic liquids containing F element. This will expand the application of high strength aluminum alloys.Originality/valueThe phosphate ionic liquid is a non‐corrosive liquid and would not cause metal corrosion. Also, the tribological properties of crown‐type phosphate ionic liquid with steel/aluminum contact are better than that of conventional ionic liquids. By the designing of molecular structure, new phosphate ionic liquids will exhibit excellent tribological properties: lower wear volume and lower friction coefficient.
Tool wear investigation whilst turning BS970‐080A15 carbon steel using TiCN‐Al2O3 CVD coated carbide tooling in gaseous and liquid nitrogen environments
Authors: Stanford M. , Lister P.M. , Kibble K.A. , Morgan C. , Sihra T. 
Published: June 2013

PurposeThe purpose of this work is to investigate the performance of non‐contaminating metal cutting environments and investigate the associated tool chip interface conditions. The work benchmarks flood coolant characteristics and considers gaseous cutting environments as possible alternatives.Design/methodology/approachCutting trials were undertaken for a range of cutting environments. Flood coolant was investigated as was dry cutting, compressed air, room temperature nitrogen and liquid nitrogen environments. A range of cutting variables was measured in order to document the effect of cutting environment.FindingsThe gaseous component of the liquid nitrogen environment limited the adhesion on the tool face to a region along the flank edge of the tool, shifting rake face conditions from seizure to that of sliding. Tighter chip curl, shorter contact lengths, reduced adhesion and lower feed forces are evidence that liquid nitrogen is acting as a “liquid inert barrier” beneath the chip within the tool/chip interface.Research limitations/implicationsOnly one tool work combination has been investigated. More tool work combinations will need to be investigated.Practical implicationsThe work demonstrated that it is possible to use environmentally safe environments during metal cutting operations. This reduces the exposure of the environment and machine tool operatives to compounds which have been shown to have detrimental effects on the environment and human health.Originality/valueThe work has led to presenting a hypothesis that liquid nitrogen acts as a “liquid inert barrier” beneath the chip within the tool/chip interface.
Effect of surface roughness on pure squeeze EHL motion of circular contacts
Authors: Chu Li‐Ming , Hsu Hsiang‐Chen , Lin Jaw‐Ren , Chang Yuh‐Ping 
Published: June 2013

PurposeThe purpose of this paper is to explore the pure squeeze elastohydrodynamic lubrication motion of circular contacts with surface roughness under constant load conditions. The proposed model can reasonably calculate the effects of surface roughness on the transient pressure profiles, film shapes, and normal squeeze velocities during the pure squeeze process.Design/methodology/approachBased on Christensen's stochastic theory, the transient modified Reynolds equation is derived in polar coordinates to consider the effects of surface roughness. The finite difference method and the Gauss‐Seidel iteration method are used to solve the transient modified Reynolds equation, the elasticity deformation equation, load balance equation, and lubricant rheology equations simultaneously.FindingsThe simulation results reveal that the circular type roughness possesses storage oil capacity. Comparatively, the radial type roughness possesses leak oil capacity. Therefore, the film thickness is found with circular type roughness, followed by smooth, and then radial type roughness. In additional, the central dimensionless pressure is found with radial type roughness, followed by smooth, and then circular type roughness.Originality/valueA numerical method for general applications with surface roughness was developed to investigate the pure squeeze action in an isothermal EHL spherical conjunction under constant load conditions, but without asperities contact.
An algorithm to prioritize welding quality deterioration factors
Authors: Chandima Ratnayake R.M. 
Published: June 2013

PurposeThe purpose of this paper is to present and implement an algorithm to prioritize welding quality deterioration factors for improving welding personnel performance. A case study is carried out in a piping components fabrication process which supplies these components to oil and gas production and processing facilities on the Norwegian continental shelf (NCS).Design/methodology/approachThe quality deterioration factors' prioritization is carried out using statistical methods in conjunction with the data recorded in the welding inspection database (WIDB) of the case study company. Data cleaning and rearrangements were performed to reflect final objective. Based on the welding procedure specifications (WPSs) and quality imperfection groups classified in NS‐EN ISO 6520‐1, the analysis is performed to prioritize the welding quality deterioration factors.FindingsBased on the WPSs and quality imperfection groups classified in NS‐EN ISO 6520‐1, it is possible to prioritize the welding quality deterioration factors. These factors are possible to use for improving the performance of welding personnel to assure the quality of welds in steel fabrications.Practical implicationsThe factors prioritized are possible to use for improving the performance of welding personnel to assure the quality and reliability of welds in a steel fabrication.Social implicationsAssuring quality as proposed in the manuscript, the catastrophic failures that are potential in production and process plants can be mitigated. This enhances health, safety and environmental performance of welds in steel fabrications.Originality/valueThe value of this paper is to illustrate an innovative approach to a real life quality problem; it demonstrates how the application of qualitative and quantitative quality instruments in accordance with technical specification can help in increasing and maintaining product compliance and in optimizing the management of resources.
Reversed variance residual life function and its properties in discrete lifetime models
Authors: Khorashadizadeh M. , Rezaei Roknabadi A.H. , Mohtashami Borzadaran G.R. 
Published: June 2013

PurposeIn reliability studies, interests in discrete failure data came relatively late in comparison to its continuous analogue. Also, discrete failure data arise in several common situations. So, in this paper the authors try to study some reliability concepts such as reversed variance and reversed mean residual life functions based on discrete lifetime random variable.Design/methodology/approachSupposed T be a non‐negative discrete random variable, then based on reversed residual random variable Tk*=(k−T|T≤k), some useful and applicable relations and bounds are achieved.FindingsIn this paper, the authors study the reversed variance residual life in discrete lifetime distributions, the results of which are not similar to the continuous case. Its relationship with reversed mean residual life and reversed residual coefficient of variation are obtained. Also, its monotonicity and the associated ageing classes of distributions are discussed. Some characterization results of the class of increasing reversed variance residual life, which is denoted by IRVR, are presented and the upper bound for reversed variance residual life under some conditions is obtained.Practical implicationsThere are many situations where a continuous time is inappropriate for describing the lifetime of devices and other systems. For example, the lifetime of many devices in industry, such as switches and mechanical tools, depends essentially on the number of times that they are turned on and off or the number of shocks they receive. In such cases, the time to failure is often more appropriately represented by the number of times they are used before they fail, which is a discrete random variable.Originality/valueAll the results based on discrete reversed residual lifetime, such as the relationships among reversed mean, variance and coefficient of variation residual lifetime and also their monotonicity ageing classes, are new.
TQM, strategy, and performance: a firm‐level analysis
Authors: Yunis Manal , Jung Joo , Chen Shouming 
Published: June 2013

PurposeThe purpose is to examine the role of TQM in a strategy‐TQM‐performance model. More specifically, it seeks to investigate whether TQM has a driving role in the formation of strategy or has a mediating effect in the strategy‐performance relationship.Design/methodology/approachA survey was used to collect data. The instrument was assessed for its validity and reliability. Structural equation modelling was employed.FindingsTQM influences strategy formulation process and it is a dynamic resource that contributes to the achievement of a sustainable competitive advantage. In addition, soft TQM has a higher impact than hard TQM on competitive strategy formulation and on performance.Research limitations/implicationsThe model developed and tested can be enriching to the TQM, strategic management, and quality management fields. Future research is recommended to use methods other than self‐report questionnaires and to account for certain behavioral factors that can influence the relationships investigated in the study.Practical implicationsThe findings provide insights to the need to integrate TQM with the various stages of the strategy formulation process, with an emphasis on the soft elements of TQM, including customer satisfaction, management and leadership, and employee relations.Originality/valueDespite the remarkable contributions of existent research, there is a lack of substantive research that examines the relationship between the hard and soft components of TQM on one hand and the two types of competitive strategy – differentiation and cost leadership – on the other. This gap is filled by this study.
The association between earnings management and asset misappropriation
Authors: Song Dan‐Bee , Lee Ho‐Young , Cho Eun‐Jung 
Published: June 2013

PurposeThe purpose of this paper is to examine whether earnings management is related to incidence of fraud and the amount of misappropriated assets. By examining the research question, this study seeks to improve our understanding of using the accrual basis of accounting in identifying the misappropriation of assets.Design/methodology/approachThis study analyzes 173 sample firms that announced asset misappropriation in the period from 2006 to 2010 in Korea. The study utilizes logistic and linear regressions to test the hypothetical relations set up in the study using discretionary accruals as a proxy of the earnings management. Additionally, the authors performed the robustness test using estimated accruals as a supplementary proxy of the earnings management.FindingsThe authors find that misappropriation of assets has a significant positive association with discretionary accruals. Interestingly, this relationship only holds for firms with negative discretionary accruals. The results suggest that the accrual basis of accounting provides a clue towards uncovering management's misappropriation of assets and thus, plays an important role in reducing existing information asymmetry.Practical implicationsThe authors' findings would assist practitioners in detecting asset misappropriation through financial reporting quality and investors and auditors should be more alert to negative discretionary accruals.Originality/valueThere are some studies that examine asset misappropriation. However, most of them are focused on the relation between asset misappropriation and corporate governance. To the best of the authors' knowledge, this is the first study that examines the association between financial reporting quality (i.e. discretionary accruals) and asset misappropriation. The authors' findings provide evidence of the usefulness of accrual basis of accounting in detecting fraud and enhance the understanding of income‐decreasing earnings management.