bluuebunny/crossref_metadata_2025_split huggingface dataset:
World Health Organization‐defined eosinophilic disorders: 2014 update on diagnosis, risk stratification, and management
Authors: Gotlib Jason 
Published: February 2014

Disease overview: The eosinophilias encompass a broad range of nonhematologic (secondary or reactive) and hematologic (primary, clonal) disorders with potential for end‐organ damage.Diagnosis: Hypereosinophilia (HE) has generally been defined as a peripheral blood eosinophil count greater than 1,500/mm3 and may be associated with tissue damage. After exclusion of secondary causes of eosinophilia, diagnostic evaluation of primary eosinophilias relies on a combination of morphologic review of the blood and marrow, standard cytogenetics, fluorescent in situ hybridization, flow immunocytometry, and T‐cell clonality assessment to detect histopathologic or clonal evidence for an acute or chronic myeloid or lymphoproliferative disorder.Risk stratification: Disease prognosis relies on identifying the subtype of eosinophilia. After evaluation of secondary causes of eosinophilia, the 2008 World Health Organization establishes a semimolecular classification scheme of disease subtypes including “myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1', chronic eosinophilic leukemia, not otherwise specified” (CEL, NOS), lymphocyte‐variant HE, and idiopathic hypereosinophilic syndrome (HES), which is a diagnosis of exclusion.Risk‐adapted therapy: The goal of therapy is to mitigate eosinophil‐mediated organ damage. For patients with milder forms of eosinophilia (e.g., <1,500/mm3) without symptoms or signs of organ involvement, a watch and wait approach with close‐follow‐up may be undertaken. Identification of rearranged PDGFRA or PDGFRB is critical because of the exquisite responsiveness of these diseases to imatinib. Corticosteroids are first‐line therapy for patients with lymphocyte‐variant HE and HES. Hydroxyurea and interferon‐alpha have demonstrated efficacy as initial treatment and steroid‐refractory cases of HES. In addition to hydroxyurea, second‐line cytotoxic chemotherapy agents and hematopoietic cell transplant have been used for aggressive forms of HES and CEL with outcomes reported for limited number of patients. Although clinical trials have been performed with anti‐IL‐5 (mepolizumab) and anti‐CD52 (alemtuzumab) antibodies, their therapeutic role in primary eosinophilic diseases and HES has yet to be established. Am. J. Hematol. 89:326–337, 2014. © 2014 Wiley Periodicals, Inc.
Static Output Feedback Control for Interval Type‐2 T‐S Fuzzy Systems Based on Fuzzy Lyapunov Functions
Authors: Zhao Tao , Xiao Jian , Han Lu , Qiu Cunyong , Huang Jingchun 
Published: February 2014

AbstractThis study aims to design an interval type‐2 (IT2) fuzzy static output feedback controller to stabilize the IT2 Takagi‐Sugeno (T‐S) fuzzy system. Conservative results may be obtained when a common quadratic Lyapunov function is utilized to investigate the stability of T‐S fuzzy systems. A fuzzy Lyapunov function is employed in this study to analyze the stability of the IT2 fuzzy closed‐loop system formed by the IT2 T‐S fuzzy model and the IT2 fuzzy static output feedback controller. Stability conditions in the form of linear matrix inequalities are derived. Several slack matrices are introduced to further reduce the conservativeness of stability analysis. The membership‐function shape‐dependent analysis approach is also employed to relax the stability results. The numerical examples illustrate the effectiveness of the proposed conditions.
ASIS&T annual meeting pre‐conference activities: The 9th annual social informatics research symposium
Authors: Fichman Pnina , Rosenbaum Howard 
Published: February 2014

AbstractEDITOR'S SUMMARYAt its 9th annual symposium, ASIS&T Special Interest Group/Social Informatics (SIG/SI) explored information boundaries from a social informatics perspective. William Jones' keynote address focused on dissolving boundaries around personal information and practical approaches to managing appropriate access. Contributed papers examined boundaries of big data, the diverse forces shaping information boundaries and technology use in human service and barriers preventing equal information access for native Spanish speakers. Presenters discussed location‐based services' ability to overcome boundaries as convenient or creepy and museums' use of indigenous groups' artifacts as an insensitive boundary violation. Since social informatics spans many interest groups, SIG/SI looks forward to further stimulating cross‐topical research.
ASIS&T annual meeting pre‐conference activities: Information behavior on the move: 2013 ASIS&T SIG/USE research symposium
Authors: Agosto Denise E. , Mon Lorri , Tang Rong 
Published: February 2014

AbstractEDITOR'S SUMMARYThe 13th Annual SIG/USE Research Symposium focused on ways mobile technologies have influenced information needs, seeking and use. In her keynote address, Caroline Haythornthwaite framed movement as changing contributorship, interactions and participation in multiple knowledge communities. A series of Ignite talks on the common theme of mobility followed, with topics ranging from mobile phones as the preferred Internet access device, credibility of mobile applications and online resources and public libraries' use of social media and mobile applications to mobile apps promoting health information literacy and supporting teleworking. Small groups brainstormed on opportunities, challenges and research ideas inspired by the theme. Annual SIG/USE awards recognized scholars for innovative work on topics including refugees' information seeking, factors influencing scholars' data sharing and drawings as visual representations of information. The symposium closed with encouragement to consider how information on the move influences perspectives and research into information behavior.
ASIS&T annual meeting award winners: Research: Computer‐mediated communication
Authors: Herring Susan C. 
Published: February 2014

AbstractEDITOR'S SUMMARYOn receiving the 2013 ASIS&T Research Award, Susan Herring reflected on her early interest in computer‐mediated communication (CMC) in 1991, when the field was novel, limited and barely recognized. The intersection of linguistics and digital technology were intriguing and offered potential for rich discovery. Data sources have grown from the foundational ARPAnet to the World Wide Web and expanded from the exchange of basic textual messages to incorporate all modes of digitally mediated communication across unlimited platforms. The result is a vast amount of computer‐mediated data, but there is still the pressing need for structured methods and theoretical frameworks for effective analysis. Herring applies discourse analysis and other linguistic approaches to CMC analysis, increasingly in combination with a big data perspective to identify communication patterns in large datasets. She is eager to see further research on new analytical methods, cultural influences and the integration of telepresence robots in CMC.
Outcome of TCF3‐PBX1 positive pediatric acute lymphoblastic leukemia patients in Japan: a collaborative study of Japan Association of Childhood Leukemia Study (JACLS) and Children's Cancer and Leukemia Study Group (CCLSG)
Authors: Asai Daisuke , Imamura Toshihiko , Yamashita Yuka , Suenobu So‐ichi , Moriya‐Saito Akiko , Hasegawa Daiichiro , Deguchi Takao , Hashii Yoshiko , Endo Mikiya , Hatakeyama Naoki , Kawasaki Hirohide , Hori Hiroki , Horibe Keizo , Yumura‐Yagi Keiko , Hara Junichi , Watanabe Arata , Kikuta Atsushi , Oda Megumi , Sato Atsushi ,   the Japan Association of Childhood Leukemia Study (JACLS) & Children's Cancer and Leukemia Study Group (CCLSG)
Published: February 2014

AbstractThis study reviewed the clinical characteristics of 112 pediatric B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) patients with TCF3‐PBX1 fusion treated according to the Japan Association of Childhood Leukemia Study (JACLS) ALL02 protocol (n = 82) and Children's Cancer and Leukemia Study Group (CCLSG) ALL 2004 protocol (n = 30). The 3‐year event‐free survival (EFS) and overall survival (OS) rates were 85.4 ± 3.9% and 89.0 ± 3.5% in JACLS cohort, and the 5‐year EFS and OS were 82.8 ± 7.0% and 86.3 ± 6.4% in CCLSG cohort, respectively, which are comparable to those reported in western countries. Conventional prognostic factors such as age at onset, initial white blood cell count, and National Cancer Institute risk have also no impact on OS in both cohorts. Surprisingly, the pattern of relapse in JACLS cohort, 9 of 82 patients, was unique: eight of nine patients relapsed during the maintenance phase and one patient had primary induction failure. However, bone marrow status and assessment of minimal residual disease on days 15 and 33 did not identify those patients. Interestingly, the two patients with IKZF1 deletion eventually relapsed in JACLS cohort, as did one patient in CCLSG cohort. International collaborative study of larger cohort is warranted to clarify the impact of the IKZF1 deletion on the poor outcome of TCF3‐PBX1 positive BCP‐ALL.
The efficacy of “hybrid” percutaneous coronary intervention in chronic total occlusions caused by in‐stent restenosis: Insights from a US multicenter registry
Authors: Christopoulos Georgios , Karmpaliotis Dimitri , Alaswad Khaldoon , Lombardi William L. , Grantham J. Aaron , Rangan Bavana V. , Kotsia Anna P. , Lembo Nicholas , Kandzari David E. , Lee James , Kalynych Anna , Carlson Harold , Garcia Santiago , Banerjee Subhash , Thompson Craig A. , Brilakis Emmanouil S. 
Published: February 2014

ObjectivesTo examine the success and complication rates in percutaneous coronary intervention (PCI) for chronic total occlusions (CTO) caused by in‐stent restenosis (ISR).BackgroundPCI for in‐stent total occlusive disease has traditionally been associated with low success rates. We sought to examine angiographic and procedural outcomes of patients who underwent CTO PCI due to ISR using the novel “hybrid” algorithm, and compare them with patients with de novo CTOs.MethodsWe examined 521 consecutive patients who underwent CTO PCI at five high‐volume PCI centers in the United States using the “hybrid” approach. Clinical, angiographic, and procedural outcomes were compared between CTOs due to ISR and de novo CTOs.ResultsThe target CTO was due to ISR in 57 of 521 patients (10.9%). Compared to patients with de novo CTOs, those with CTO due to ISR had higher frequency of diabetes (56.1% vs. 39.6%, P = 0.02) and less calcification (5.3% vs. 16.2%, P <0.001), but longer occlusion length [38 (29–55) vs. 30 (20–51), P = 0.04]. Technical success in the ISR and de novo group was 89.4% and 92.5% (P = 0.43), respectively; procedural success was 86.0% and 90.3% (P = 0.31), respectively; and the incidence of major adverse cardiac events was 3.5% and 2.2% (P = 0.63), respectively.ConclusionsUse of the “hybrid” approach to CTO PCI was associated with similarly high procedural success and similarly low major complication rates in patients with de novo and ISR CTOs. © 2014 Wiley Periodicals, Inc.
Sitting Posture Makes a Difference—Embodiment Effects on Depressive Memory Bias
Authors: Michalak Johannes , Mischnat Judith , Teismann Tobias 
Published: February 2014

Basic research has shown that the motoric system (i.e., motor actions or stable postures) can strongly affect emotional processes. The present study sought to investigate the effects of sitting posture on the tendency of depressed individuals to recall a higher proportion of negative self‐referent material. Thirty currently depressed inpatients either sat in a slumped (depressed) or in an upright (non‐depressed) posture while imagining a visual scene of themselves in connection with positive or depression related words presented to them on a computer screen. An incidental recall test of these words was conducted after a distraction task. Results of a mixed ANOVA showed a significant posture x word type interaction, with upright‐sitting patients showing unbiased recall of positive and negative words but slumped patients showing recall biased towards more negative words. The findings indicate that relatively minor changes in the motoric system can affect one of the best‐documented cognitive biases in depression. Practical implications of the findings are discussed. Copyright © 2014 John Wiley & Sons, Ltd.Key Practitioner MessageFeatures of patients' motoric system (i.e., habitual movement patterns or body postures) might be relevant for individual case conceptualization.Training patients to change habitual motoric patterns (e.g., dysfunctional posture or movement patterns) might attenuate negatively biased information processing in depressed patients.Training patients in mindful body awareness might be useful because it fosters an intuitive understanding of the interplay of bodily and emotional processes.
A 5‐Gbps USB3.0 transmitter and receiver linear equalizer
Authors: Terzopoulos Nikolaos , Laoudias Costas , Plessas Fotis , Souliotis George , Koutsomitsos Sotiris , Birbas Michael 
Published: February 2014

SummaryA USB3.0 compatible transmitter and the linear equalizer of the corresponding receiver are presented in this paper. The architecture and circuit design techniques used to meet the strict requirements of the overall link design are explored. Output voltage amplitude and de‐emphasis levels are programmable, whereas the output impedance is calibrated to 50Ω. A programmable receiver equalizer is also presented with its main purpose being to compensate for the channel losses; this is employed together with a DC offset compensation scheme. The 6.25‐GHz equalizer provides a 10 dB overall gain equalization and 5.5‐dB peaking at the maximum gain setting. Designed using a mature and well established 65 nm complementary metal oxide semiconductor process, the layout area is 400 µm × 210 µm for the transmitter core, and 140 µm × 70 µm for the equalizer core. The power consumption is 55 and 4 mW, respectively, from a 1.2 V supply at a data rate of 5 Gbps. The target application for such high‐speed blocks is to implement the critical part of the physical layer that defines the signaling technology of SuperSpeed USB3 PHY. However, identical iterations of the circuitry discussed can be used for similar high‐speed applications like the PCI express (PCIe). Copyright © 2014 John Wiley & Sons, Ltd.
A quantitative life history of endangered humpback chub that spawn in theLittleColoradoRiver: variation in movement, growth, and survival
Authors: Yackulic Charles B. , Yard Michael D. , Korman Josh , Van Haverbeke David R. 
Published: February 2014

AbstractWhile the ecology and evolution of partial migratory systems (defined broadly to include skip spawning) have been well studied, we are only beginning to understand how partial migratory populations are responding to ongoing environmental change. Environmental change can lead to differences in the fitness of residents and migrants, which could eventually lead to changes in the frequency of the strategies in the overall population. Here, we address questions concerning the life history of the endangeredGila cypha(humpback chub) in the regulatedColoradoRiver and the unregulated tributary and primary spawning area, theLittleColoradoRiver. We develop eight multistate models for the population based on three movement hypotheses, in which states are defined in terms of fish size classes and river locations. We fit these models to mark–recapture data collected in 2009–2012. We compare survival and growth estimates between theColoradoRiver andLittleColoradoRiver and calculate abundances for all size classes. The best model supports the hypotheses that larger adults spawn more frequently than smaller adults, that there are residents in the spawning grounds, and that juveniles move out of the Little Colorado River in large numbers during the monsoon season (July–September). Monthly survival rates forG. cyphain theColoradoRiver are higher than in theLittleColoradoRiver in all size classes; however, growth is slower. While the hypothetical life histories of life‐long residents in theLittleColoradoRiver and partial migrants spending most of its time in theColoradoRiver are very different, they lead to roughly similar fitness expectations when we used expected number of spawns as a proxy. However, more research is needed because our study period covers a period of years when conditions in theColoradoRiver forG. cyphaare likely to have been better than has been typical over the last few decades.
How do climate and forest changes affect long‐term streamflow dynamics? A case study in the upper reach of Poyang River basin
Authors: Liu Wenfei , Wei Xiaohua , Liu Shirong , Liu Yuanqiu , Fan Houbao , Zhang Mingfang , Yin Jianmin , Zhan Mingjin 
Published: February 2014

AbstractIn forested watersheds, forest changes and climatic variability have been commonly recognized as two major drivers for streamflow variations. Previous research has separated their relative contributions but mainly focused on either deforestation and climate or reforestation and climate, but rarely with single studies on both. This study used the Meijiang watershed (6983·2 km2), situated in the upper reach of the Poyang Lake basin, as an example to quantify how climate and forest changes (both deforestation and reforestation) consecutively affect streamflow dynamics. Two methods, namely modified double‐mass curves and sensitivity‐based approach, were used in this study. Two breakpoints (years 1968 and 1985) with significant annual streamflow changes were detected, and together with the control period, they were then used to define three distinct periods: the control (1957–1967), deforestation (1968–1984) and reforestation (1985–2006) periods. Our results show that in the deforestation period, the average annual streamflow increment attributed to deforestation was 112·78 mm year−1, while the annual streamflow variation attributed to climate variability was −111·39 mm year−1. In the reforestation period, the average annual streamflow decrease caused by reforestation was −51·04 mm year−1, while the annual streamflow variation attributed to climate variability was 52·52 mm year−1. The sensitivity‐based approach also provided similar results. The positive and negative values in the streamflow changes suggest offsetting effects between forest changes and climate variability in both deforestation and reforestation periods. The similar magnitudes of streamflow changes demonstrate that the hydrological effects of forest changes can be as great as those caused by climate change. Copyright © 2014 John Wiley & Sons, Ltd.
Defects in GABA metabolism affect selective autophagy pathways and are alleviated by mTOR inhibition
Authors: Lakhani Ronak , Vogel Kara R , Till Andreas , Liu Jingjing , Burnett Sarah F , Gibson K Michael , Subramani Suresh 
Published: February 2014

AbstractIn addition to key roles in embryonic neurogenesis and myelinogenesis, γ‐aminobutyric acid (GABA) serves as the primary inhibitory mammalian neurotransmitter. In yeast, we have identified a new role for GABA that augments activity of the pivotal kinase, Tor1. GABA inhibits the selective autophagy pathways, mitophagy and pexophagy, through Sch9, the homolog of the mammalian kinase, S6K1, leading to oxidative stress, all of which can be mitigated by the Tor1 inhibitor, rapamycin. To confirm these processes in mammals, we examined the succinic semialdehyde dehydrogenase (SSADH)‐deficient mouse model that accumulates supraphysiological GABA in the central nervous system and other tissues. Mutant mice displayed increased mitochondrial numbers in the brain and liver, expected with a defect in mitophagy, and morphologically abnormal mitochondria. Administration of rapamycin to these mice reduced mTOR activity, reduced the elevated mitochondrial numbers, and normalized aberrant antioxidant levels. These results confirm a novel role for GABA in cell signaling and highlight potential pathomechanisms and treatments in various human pathologies, including SSADH deficiency, as well as other diseases characterized by elevated levels of GABA.
Antiosteoporotic effect of orally administered yolk‐derived peptides on bone mass in women
Authors: Abdou Adham M. , Watabe Kazuya , Yamane Tetsuro , Isono Tadayuki , Okamura Yoshitaka , Kawahito Seiji , Takeshima Kazuhito , Masuda Kazuyuki , Kim Mujo 
Published: February 2014

AbstractThe main objective of this study was to verify the effect of oral intake of a yolk‐derived peptide preparation (HYP) obtained by enzymatic hydrolysis of yolk water‐soluble protein on bone markers and bone density in 65 perimenopausal women with an average age of 47.6 ± 5.2 years. Subjects were divided into three groups, and then enrolled in a 6‐month, randomized, double‐blind clinical trial. Bone formation and resorption markers were measured at 0, 3, and 6 months, while bone mineral density (BMD) in the lumbar spines was measured at 0 and 6 months. Although the bone formation marker levels showed the similarity changes among the groups, bone resorption markers in the test HYP group were significantly decreased after 3 and 6 months in comparison to other groups (P < 0.05). After 6 months, BMD in the test HYP group maintained at healthy numerical values whereas BMD values were decreased in other groups. Hence HYP would be an antiosteoporotic agent originated from natural food to maintain bone health, especially for women.
Enhancing safety and shelf life of fresh‐cut mango by application of edible coatings and microencapsulation technique
Authors: Alikhani Majid 
Published: February 2014

AbstractMango pulp is very perishable and so has a short shelf life, which both marketers and consumers would like to be longer. Manually sliced mango was treated by coating opuntia mucilage‐rosemary oil (Mu + RO), 2 g rosemary oil microencapsul (ROM), and 2 g (ROM) plus (Mu + RO); the treated mango pieces were placed in plastic trays, and overwrapped with PVDC film and then stored at 6°C. Changes in the quality parameters and activity of peroxidase (POD) enzyme were evaluated for 9 days of storage period. These treatments retarded loss of ascorbic acid and the drop in sensory acceptability, fewer changes in color, decreasing activity POD enzyme. These also inhibited the decay incidence and slowed microbial growth. The (Mu + RO) treatment was more effective in controlling postharvest quality as compared to the (ROM) treatment, but the data reveal that applying the compound treatment effectively prolongs the quality attributes and extends the storage life of sliced mango fruit.