bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Catalytic Asymmetric Dearomatizing Redox Cross Coupling of Ketones with Aryl Hydrazines Giving 1,4‐Diketones.
Authors: Huang Shenlin , Koetzner Lisa , De Chandra Kanta , List Benjamin 
Published: August 2015

Abstract1,4‐Diketones bearing an all‐carbon quarternary stereocenter are synthesized via asymmetric dearomatizing redox cross‐coupling reaction between aryl hydrazines and cyclic ketones in the presence of a SPINOL‐derived phosphoric acid as chiral catalyst.
ChemInform Abstract: Efficient Sonogashira and Suzuki—Miyaura Coupling Reaction Catalyzed by Pd‐Nanoparticles.
Authors: Balsane Kishor E. , Shendage Suresh S. , Nagarkar Jayashree M. 
Published: August 2015

AbstractPd nanoparticles, electrochemically deposited on Nafion‐graphene, show excellent catalytic activity in the title C—C cross‐coupling reactions.
ChemInform Abstract: A One‐Pot O‐Sulfinative Passerini/Oxidation Reaction: Synthesis of α‐(Sulfonyloxy)amide Derivatives.
Authors: Soeta Takahiro , Matsuzaki Syunsuke , Ukaji Yutaka 
Published: August 2015

AbstractCinnamyl and aryl aldehydes as well as aryl isocyanides [except (VI)] do not react or give low yields only.
ChemInform Abstract: General Preparation of 1‐Substituted (E)‐1,3‐Dienes under Mild Conditions.
Authors: Soengas Raquel G. , Rodriguez‐Solla Humberto , Diaz‐Pardo Ainhoa , Acurcio Rita , Concellon Carmen , del Amo Vicente , Silva Artur M. S. 
Published: August 2015

AbstractThis straightforward protocol is based on a reductive, metal‐mediated β‐elimination reaction of chloroallylacetates affording 1‐substituted 1,3‐dienes stereoselectively with high yields.
ChemInform Abstract: Silver‐Catalyzed Ring‐Opening Strategy for the Synthesis of β‐ and γ‐Fluorinated Ketones.
Authors: Zhao Huijun , Fan Xuefeng , Yu Jiajia , Zhu Chen 
Published: August 2015

AbstractStarting from tertiary cyclopropanol and cyclobutanol precursors, a variety of β‐ and γ‐fluorinated ketones are efficiently synthesized via silver‐catalyzed ring opening reactions.
ChemInform Abstract: Palladium Catalyzed Vinyltrifluoromethylation of Aryl Halides Through Decarboxylative Cross‐Coupling with 2‐(Trifluoromethyl)acrylic Acid.
Authors: Kathiravan Subban , Nicholls Ian A. 
Published: August 2015

AbstractA stereoselective synthesis of β‐(trifluoromethyl)styrenes from aryl bromides is presented.
ChemInform Abstract: Facile and Diverse Microwave‐Assisted Synthesis of Secondary Propargylamines in Water Using CuCl/CuCl2.
Authors: Trang Tran Thi Thu , Ermolat'ev Denis S. , Van der Eycken Erik V. 
Published: August 2015

AbstractThe novel protocol provides a wide range of secondary propargylamines equipped with diverse substituents in generally high yields.
ChemInform Abstract: 1,4‐Hydroiodination of Dienyl Alcohols with TMSI to Form Homoallylic Alcohols Containing a Multisubstituted Z‐Alkene and Application to Prins Cyclization.
Authors: Xu Yongjin , Yin Zhiping , Lin Xinglong , Gan Zubao , He Yanyang , Gao Lu , Song Zhenlei 
Published: August 2015

AbstractA new regioselective 1,4‐hydroiodination of dienyl alcohols is developed using trimethylsilyl iodide as Lewis acid and iodide source.
ChemInform Abstract: Synthesis of New Sulfonyloximes and Their Use in Free‐Radical Olefin Carbo‐Oximation.
Authors: Ovadia Benjamin , Robert Frederic , Landais Yannick 
Published: August 2015

AbstractBifunctional sulfonyl oximes are prepared and utilized in tin‐mediated radical addition reactions with alkenes to yield functionalized oxime ethers.
ChemInform Abstract: Organocatalytic Enantioselective α‐Hydroxymethylation of Aldehydes: Mechanistic Aspects and Optimization.
Authors: Boeckman Robert K. Jr. , Biegasiewicz Kyle F. , Tusch Douglas J. , Miller John R. 
Published: August 2015

AbstractThe reaction proceeds via the 1,3‐dioxane‐4‐ol intermediates (III) that can be trapped by Pinnick oxidation as α‐hydroxymethylalkanoic acids or by Wittig reaction with (IX) as 2‐methyl‐4‐hydroxymethyl‐alk‐2‐enoic acid esters.
ChemInform Abstract: Acyl Azolium Fluorides for Room Temperature Nucleophilic Aromatic Fluorination of Chloro‐ and Nitroarenes.
Authors: Ryan Sarah J. , Schimler Sydonie D. , Bland Douglas C. , Sanford Melanie S. 
Published: August 2015

AbstractSNAr fluorination of chloro‐ and nitro arenes is accomplished using acyl azolium fluorides, generated from acyl fluorides and an N‐heterocyclic carbene.
ChemInform Abstract: C—N Cross‐Coupling Reaction Catalyzed by Reusable CuCr2O4 Nanoparticles under Ligand‐Free Conditions: A Highly Efficient Synthesis of Triarylamines.
Authors: Safaei‐Ghomi Javad , Akbarzadeh Zeinab , Khojastehbakht‐Koopaei Bahareh 
Published: August 2015

AbstractThe efficient procedure provides the products with high yields.
ChemInform Abstract: One‐Pot Synthesis of 3‐Hydroxyanthranilate Derivatives Using Furans, Bromoalkyne, and Secondary Amines.
Authors: Shinohara Hiroyuki , Sonoda Motohiro , Hayagane Naoya , Kita Shota , Okushima Shunsuke , Tanimori Shinji , Ogawa Akiya 
Published: August 2015

AbstractThe synthesis of 3‐hydroxyanthranilate derivatives is achieved through Diels—Alder reaction of furans with alkyne (II), followed by conjugate addition of amine, dehydrobromination, and a ring‐opening aromatization reaction.
ChemInform Abstract: Fe(TAML)Li/tert‐Butyl Hydroperoxide as a New Combination for Benzylic C—H Oxidation.
Authors: Napoly Francois , Kieffer Raphaelle , Jean‐Gerard Ludivine , Goux‐Henry Catherine , Draye Micheline , Andrioletti Bruno 
Published: August 2015

AbstractA new mild and environmental friendly benzylic oxidation with good to excellent yields is presented.
ChemInform Abstract: Air Oxidative Radical Hydroxysulfurization of Styrenes Leading to β‐Hydroxysulfides.
Authors: Zhou Shao‐Fang , Pan Xiangqiang , Zhou Zhi‐Hao , Shoberu Adedamola , Zou Jian‐Ping 
Published: August 2015

AbstractAside the shown failed reactions, the following substrates also do not react: allylbenzene and 4‐phenylbut‐1‐ene as well as 2‐sulfanylfuran and ‐pyridine.
ChemInform Abstract: N‐Heterocyclic Carbene—Palladium(II)‐1‐methylimidazole Complex‐Catalyzed Suzuki—Miyaura Coupling of Benzyl Sulfonates with Arylboronic Acids.
Authors: Wang Xiao‐Xia , Xu Bin‐Bin , Song Wen‐Ting , Sun Kai‐Xin , Lu Jian‐Mei 
Published: August 2015

AbstractVarious diarylmethanes are conveniently and efficiently obtained.
ChemInform Abstract: Nickel‐Catalyzed Three‐Component Domino Reactions of Aryl Grignard Reagents, Alkynes, and Aryl Halides Producing Tetrasubstituted Alkenes.
Authors: Xue Fei , Zhao Jin , Hor T. S. Andy , Hayashi Tamio 
Published: August 2015

AbstractA three‐component Ni‐catalyzed coupling reaction of internal alkynes with aryl Grignard reagents and aryl iodides is presented to give fully substituted tetraaryl and triaryl ethenes.
ChemInform Abstract: Facile Synthesis of Spirooxindole‐Pyrazolines and Spirobenzofuranone‐Pyrazolines and Their Fungicidal Activity.
Authors: Yang Changjiang , Li Juanjuan , Zhou Rong , Chen Xiangyu , Gao Yunpeng , He Zhengjie 
Published: August 2015

AbstractA variety of the spirocyclic heterocycles are synthesized in good yields by annulation reactions of corresponding 3‐alkylideneoxindoles or 3‐alkylidenebenzofuranones with Huisgen zwitterions.
ChemInform Abstract: Unique Chemoselective Paal—Knorr Reaction Catalyzed by MgI2 Etherate under Solvent‐Free Conditions.
Authors: Zhang Xingxian , Weng Guodong , Zhang Yongdong , Li Pengcheng 
Published: August 2015

AbstractA simple solvent‐free procedure is elaborated for the synthesis of pyrroles (III) and (V) from amines and diones.
ChemInform Abstract: Manganese Catalyzed C—H Functionalization of Indoles with Alkynes to Synthesize Bis/trisubstituted Indolylalkenes and Carbazoles: The Acid is the Key to Control Selectivity.
Authors: Shi Lijun , Zhong Xiang , She Houde , Lei Ziqiang , Li Fuwei 
Published: August 2015

AbstractC—H alkenylation reactions of indoles with terminal‐ and internal alkynes are presented.
ChemInform Abstract: An NHC‐Catalyzed in situ Activation Strategy to β‐Functionalize Saturated Carboxylic Acid: An Enantioselective Formal [3 + 2] Annulation for Spirocyclic Oxindolo‐γ‐butyrolactones.
Authors: Xie Yuanwei , Yu Chenxia , Li Tuanjie , Tu Shujiang , Yao Changsheng 
Published: August 2015

AbstractIn situ activation of the starting carboxylic acids renders possible a direct functionalization at the unreactive β‐position.
ChemInform Abstract: Divergent Construction of Pyrazoles via Michael Addition of N‐Arylhydrazones to 1,2‐Diaza‐1,3‐dienes.
Authors: Mantenuto Serena , Mantellini Fabio , Favi Gianfranco , Attanasi Orazio A. 
Published: August 2015

AbstractThe NaH‐catalyzed Michael addition of N‐arylhydrazones (II) with 1,2‐diaza‐1,3‐dienes leads to novel β‐azohydrazones (III), which are converted into hydroxyl pyrazoles (IV) by a ring closure reaction in the presence of a stoichiometric amount of NaH.
ChemInform Abstract: Silica Gel Promoted Environment‐Friendly Synthesis of α‐Amino Amidines and Regioselective Transformation of α‐Amino Amidines into Amidino Substituted Indazoles.
Authors: Sagar A. , Babu Venkata Nagarjuna , Sharada Duddu. S. 
Published: August 2015

AbstractThe scalable preparation of α‐amino amidines is based on a three‐component Ugi‐type reaction promoted by silica gel which is recycled and reused in two successive runs with marginal loss of its activity.
ChemInform Abstract: Expedient Synthesis of Benzimidazoles Using Amides.
Authors: Kattimani Pramod P. , Kamble Ravindra R. , Meti Gangadhar Y. 
Published: August 2015

AbstractThe synthesis of benzimidazoles starting from substituted phenylen‐1,2‐diamines and N,N‐dimethylformamide, aryl or alkyl amides is performed under conventional heating as well as heating under microwave irradiation with the latter providing higher product yields after shorter reaction times.
ChemInform Abstract: Dithiocarbamate Promoted Practical Synthesis of N‐Aryl‐2‐aminobenzazoles: Synthesis of Novel Aurora‐A Kinase Inhibitor.
Authors: Katari Naresh Kumar , Venkatanarayana M. , Srinivas Kummari 
Published: August 2015

AbstractA variety of 2‐arylaminobenzoxazole and ‐thiazole derivatives are synthesized via reactions of corresponding o‐amino(thio)phenols with dithiocarbamate.
ChemInform Abstract: An Efficient Method for the Synthesis of Substituted 5‐Aminotetrazoles from Selenoureas Using PhI(OAc)2.
Authors: Xie Yuanyuan , Guo Dongyan , Jiang Xiaoying , Pan Haixuan , Wang Wenhui , Jin Tingting , Mi Zhisheng 
Published: August 2015

AbstractA metal‐free and environmentally acceptable synthesis of 5‐aminotetrazoles is presented.
ChemInform Abstract: β‐Cyclodextrin as a Supramolecular Catalyst for the Synthesis of Dihydropyrano[2,3‐c]pyrazole and Spiro[indoline‐3,4′‐pyrano[2,3‐c]pyrazole] in Aqueous Medium.
Authors: Tayade Yogesh A. , Padvi Swapnil A. , Wagh Yogesh B. , Dalal Dipak S. 
Published: August 2015

AbstractThe methodology is advantageous with regards to higher yields of products, short reaction times, and neutral reaction conditions.
ChemInform Abstract: Bromodimethylsulfonium Bromide: An Efficient Catalyst for One‐Pot Synthesis of 4‐Phenacylidene Flavene Derivatives.
Authors: Bhattacharjee Suchandra , Das Deb K. , Khan Abu T. 
Published: August 2015

AbstractA facile protocol is presented for the synthesis of the title species through condensation of salicylaldehydes and acetophenones.
ChemInform Abstract: Visible‐Light Initiated Oxidative Cyclization of Phenyl Propiolates with Sulfinic Acids to Coumarin Derivatives under Metal‐Free Conditions.
Authors: Yang Wenchao , Yang Shuai , Li Pinhua , Wang Lei 
Published: August 2015

AbstractA simple procedure is elaborated for the synthesis of coumarins by an eosin‐catalyzed photooxidative cyclization of aryl 3‐arylpropionates with sulfinic acids.
ChemInform Abstract: Copper‐Catalyzed C—H Alkylation of 8‐Aminoquinolines via 8‐Amide Chelation Assistance.
Authors: Xia Xiao‐Feng , Zhu Su‐Li , Gu Zhen , Wang Haijun 
Published: August 2015

AbstractThe operationally simple method delivers 2‐substituted 8‐aminoquinolines upon application of tertiary alkyl carboxylic acids as the alkylating agent.
ChemInform Abstract: Highly Enantioselective Catalytic Cross‐Dehydrogenative Coupling of N‐Carbamoyl Tetrahydroisoquinolines and Terminal Alkynes.
Authors: Sun Shutao , Li Chengkun , Floreancig Paul E. , Lou Hongxiang , Liu Lei 
Published: August 2015

AbstractThe reaction provides access to 1‐alkinyl substituted 1,2,3,4‐tetrahydroisoquinolines while tolerating a range of functional groups on both, the tetrahydroisoquinoline and the alkyne moiety.
ChemInform Abstract: One‐Pot Synthesis of Highly Substituted N‐Fused Heteroaromatic Bicycles from Azole Aldehydes.
Authors: Outlaw Victor K. , d'Andrea Felipe B. , Townsend Craig A. 
Published: August 2015

AbstractStarting from pyrrole‐ and imidazolecarboxaldehydes, Wittig olefination or alkylation with fumaronitrile and sequential cycloaromatization leads to indolizines and imidazopyridines, respectively.
ChemInform Abstract: Au‐Catalyzed Ring‐Opening Reactions of 2‐(1‐Alkynyl‐cyclopropyl)pyridines with Nucleophiles.
Authors: Liu Ren‐Rong , Ye Shi‐Chun , Lu Chuan‐Jun , Xiang Bin , Gao Jianrong , Jia Yi‐Xia 
Published: August 2015

AbstractStructurally diverse indolizines are efficiently obtained under mild reaction conditions by gold‐catalyzed cycloisomerization of 2‐(1‐alkynylcyclopropyl)pyridines in the presence of a series of N‐, C‐, and O‐ based nucleophiles.
ChemInform Abstract: A Rapid Route for the Preparation of Pyrimido[5,4‐d]‐ and Pyrido[3,2‐d]oxazoles.
Authors: Lemaire Lucas , Leleu‐Chavain Natascha , Tourteau Aurelien , Abdul‐Sada Alaa , Spencer John , Millet Regis 
Published: August 2015

AbstractThe substrate (I) is found to be a very efficient building block for the construction of the title heterocycles.
ChemInform Abstract: A Simple Approach for the Syntheses of Rutaecarpine and Its Analogues.
Authors: Liang Li‐Na , An Rui , Huang Tao , Xu Mei , Hao Xiao‐Jiang , Pan Wei‐Dong , Liu Sheng 
Published: August 2015

AbstractThe novel three step route to rutaecarpine (VIa) and its analogues involves the cyclization of compound (V) as key step.
ChemInform Abstract: Palladium‐Catalyzed Csp2—H Carbonylation of Aromatic Oximes: Selective Access to Benzo[d][1,2]oxazin‐1‐ones and 3‐Methyleneisoindolin‐1‐ones.
Authors: Xu Yanli , Hu Weigao , Tang Xiaodong , Zhao Jinwu , Wu Wanqing , Jiang Huanfeng 
Published: August 2015

AbstractThe N—OH group acts either as a directing and/or an internal oxidant depending on the applied conditions.
ChemInform Abstract: Transfer of Chirality in the Rhodium‐Catalyzed Intramolecular Formal Hetero‐[5 + 2] Cycloaddition of Vinyl Aziridines and Alkynes: Stereoselective Synthesis of Fused Azepine Derivatives.
Authors: Feng Jian‐Jun , Lin Tao‐Yan , Wu Hai‐Hong , Zhang Junliang 
Published: August 2015

AbstractIt is demonstrated, that the stereochemical information of vinyl‐alkyne substrates containing a chiral aziridine substituent can be transferred to fused dihydroazepine derivatives by a Rh‐catalyzed formal [5 + 2] cyclization.
ChemInform Abstract: Synthesis of Vinyl Boronates from Aldehydes by a Practical Boron—Wittig Reaction.
Authors: Coombs John R. , Zhang Liang , Morken James P. 
Published: August 2015

AbstractA scalable, transition‐metal free Wittig reaction starting from geminally substituted and unsubstituted bis(boronates) and a diverse range of alkyl, alkenyl, and alkynyl aldehydes to 1,2‐ and 1,2‐disubstitued as well as trisubstituted vinyl boronates is elaborated.
ChemInform Abstract: A Quaternary Ammonium Salt [H‐dabco][AcO]: As a Recyclable and Highly Efficient Catalyst for the One‐Pot Synthesis of β‐Phosphonomalonates.
Authors: Yu Ya‐Qin , Xu Da‐Zhen 
Published: August 2015

AbstractThe scalable, operationally simple one‐pot multicomponent procedure provides the products with high to excellent yields.
ChemInform Abstract: An Approach to Asymmetric Synthesis of β‐Aryl Alanines by Pd(0)‐Catalyzed Cross‐Coupling and Cyanate‐to‐Isocyanate Rearrangement.
Authors: Szczesniak Piotr , Stecko Sebastian 
Published: August 2015

AbstractA new method for the asymmetric synthesis of β‐arylalanines (X) is developed involving the Pd‐catalyzed cross‐coupling of chiral allyl alcohols (I) with arylboronic acids and the Ichikawa sigmatropic rearrangement of allyl cyanates to isocyanates [→ (VIII)] as key steps.
ChemInform Abstract: Chaetosemins A—E, New Chromones Isolated from an Ascomycete Chaetomium seminudum and Their Biological Activities.
Authors: Li He , Tian Jun‐Mian , Tang Hao‐Yu , Pan Shi‐Yin , Zhang An‐Ling , Gao Jin‐Ming 
Published: August 2015

AbstractChaetosemins A—C (Ia‐c), D (II) and E (III) as well as chaetoquadrin J (Id) are isolated and evaluated towards their antifungal, antioxidant and sEH inhibitory activity.
ChemInform Abstract: Low‐Polydispersity Hyperbranched Polyphenylene Sulfide as a Protectant for Palladium Nanocomposites.
Authors: Meng Yuzhu , Zhang Chongyang , Xu Lan , Kuang Jinzhi , Bi Ruilin 
Published: August 2015

AbstractA new hyperbranched poly(phenylene sulfide) (HPPS) is successfully synthesized by modified polycondensation of an AB2 monomer with a core molecule.
ChemInform Abstract: Complex‐Induced Proximity Effect in Lithiation: Unveiling Recent Potentials in Organic Synthesis of Biologically Relevant Heterocyclic Compounds
Authors: Ajani Olayinka O. , Shomade Michael O. , Edobor‐Osoh Abiola , Ajanaku Christiana O. , Ajani Alice O. 
Published: August 2015

AbstractReview: 101 refs.
Mean‐Field Evolution of Fermionic Mixed States
Authors: Benedikter Niels , Jakšić Vojkan , Porta Marcello , Saffirio Chiara , Schlein Benjamin 
Published: August 2015

AbstractIn this paper we study the dynamics of fermionic mixed states in the mean‐field regime. We consider initial states that are close to quasi‐free states and prove that, under suitable assumptions on the initial data and on the many‐body interaction, the quantum evolution of such initial data is well approximated by a suitable quasi‐free state. In particular, we prove that the evolution of the reduced one‐particle density matrix converges, as the number of particles goes to infinity, to the solution of the time‐dependent Hartree‐Fock equation. Our result holds for all times and gives effective estimates on the rate of convergence of the many‐body dynamics towards the Hartree‐Fock evolution.© 2015 Wiley Periodicals, Inc.
Pharmacokinetics, Safety, and Tolerability of Once‐Daily Intranasal Fluticasone Furoate and Levocabastine Administered Alone or Simultaneously as fluticasone Furoate/Levocabastine Fixed‐Dose Combination
Authors: Allen Ann , Murdoch Robert D. , Bareille Philippe , Burns Olivia , Hughes Stephen , Gupta Ashutosh , Miller Sam R. 
Published: August 2015

AbstractPurposeThe purpose of this study was to investigate potential systemic pharmacokinetic interactions between intranasal fluticasone furoate (FF) and levocabastine (LEVO) when delivered simultaneously via a metered atomizing spray pump.MethodsThis was a randomized, open‐label, crossover study. Healthy male and female subjects (n = 30) received once‐daily repeat doses of FF/LEVO (100/200 μg) as a fixed‐dose combination (FDC), FF (110 μg), or LEVO (200 μg) for 7 days. FF and LEVO plasma pharmacokinetics (0–24 hours) were measured on day 7, with safety assessments over the study duration.ResultsSystemic exposure to LEVO was similar when administered as FF/LEVO FDC or LEVO alone. Following FF/LEVO FDC or FF alone, the majority (>99%) of FF concentrations were nonquantifiable, that is, below the lower limit of quantification of 10 pg/mL. All treatments were well tolerated, and adverse event incidence was similar across the treatment groups.ConclusionsThese results suggest that in healthy subjects, for LEVO, there is no pharmacokinetic interaction with FF when delivered as FF/LEVO FDC. As the majority of data were below the assay sensitivity for FF, any potential differences in the bioavailability of FF when delivered alone or as FF/LEVO FDC could not be established. There was no clinically relevant impact on safety/tolerability when FF/LEVO was coadministered.
Relative Bioavailability of a Single Dose of Belimumab Administered Subcutaneously by Prefilled Syringe or Autoinjector in Healthy Subjects
Authors: Struemper Herbert , Murtaugh Thomas , Gilbert Jane , Barton Matthew E. , Fire Joseph , Groark James , Fox Norma Lynn , Roth David , Gordon David 
Published: August 2015

AbstractIntravenous belimumab is approved for the treatment of systemic lupus erythematosus; subcutaneous self‐administration would enable greater patient access. This study assessed relative bioavailability, tolerability, and safety of 1 subcutaneous dose of self‐administered belimumab by healthy subjects using a single‐use autoinjector or prefilled syringe. Subjects (randomized 1:1:1:1) self‐administered belimumab 200 mg subcutaneously (abdomen or thigh) by prefilled syringe or autoinjector. Pharmacokinetics, adverse events (AEs), injection‐site pain, and administration errors were recorded. Of 81 subjects, 5 experienced administration errors and were excluded from pharmacokinetic analyses. Mean serum belimumab concentration profiles were similar for both devices, with a weak trend toward higher concentrations for thigh injection compared with abdominal injections. Maximum observed serum concentration was slightly higher with the autoinjector (27.0 vs 25.3 µg/mL) and area under the concentration–time curve slightly lower (701 vs 735 day · μg/mL), compared with the prefilled syringe. Incidence of AEs was 51% (41 of 81 subjects; headache was most common), with no serious or severe AEs. Median injection‐site pain scores were low (0 after 1 hour). Device handling was reported as acceptable by ≥95% of autoinjector users and ≥90% of prefilled syringe users for each characteristic assessed. These results support the use of either device for belimumab subcutaneous administration.
Selective Liquid‐Phase Hydrogenation of a Nitro Group in Substituted Nitrobenzenes over Au/Al2O3 Catalyst in a Packed‐Bed Flow Reactor
Authors: Nuzhdin Alexey L. , Moroz Boris L. , Bukhtiyarova Galina A. , Reshetnikov Sergey I. , Pyrjaev Pavel A. , Aleksandrov Pavel V. , Bukhtiyarov Valerii I. 
Published: August 2015

AbstractA series of substituted nitrobenzenes with the general formula XC6H4NO2 (X=Cl, CH=CH2, or C(O)CH3) dissolved in toluene were reduced with hydrogen over the 1.9 % Au/Al2O3 catalyst at 60–110 °C and 10–20 bar in a three‐phase packed‐bed reactor operating in up‐flow mode. Under these conditions, hydrogenation of isomeric ClC6H4NO2 gives exclusively chloroanilines. Hydrogenation of 3‐CH2CHC6H4NO2 and 4‐CH3C(O)C6H4NO2 leads to the formation of 3‐CH2CHC6H4NH2 and 4‐CH3C(O)C6H4NH2 with selectivities of up to 93 and 97 % at substrate conversions of 98 and 100 %, respectively. Smooth catalyst deactivation was observed regardless of which substituted nitrobenzene was taken for hydrogenation. According to the results obtained by temperature‐programmed oxidation of the spent catalyst, a carbonaceous deposit formed that might block the catalyst surface. Almost complete regeneration of the supported gold catalyst with retention of its high selectivity to hydrogenation of a nitro group was achieved in a flow of air at temperatures up to 400 °C to eliminate carbonaceous deposits.