bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aberrant STAT3 signaling in pancreatic cancer requires the lncRNA NEAT1 regulated by the metalloprotease-disintegrin ADAM8 via miR-181a-5p
Authors: Gao Yutong , Zandieh Kimia , Zhao Kai , Khizanishvili Natalia , DiFazio Pietro , Yu Xiangdi , Schulte Leon , Aillaud Michelle , Chung Ho-Ryun , Ball Zachary , Meixner Marion , Bauer Uta-Maria , Bartsch Detlef Klaus , Buchholz Malte , Lauth Matthias , Nimsky Christopher , Cook Lena , Bartsch Jörg W. 
Published: July 2024

Abstract

Purpose
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. Several studies demonstrate that ADAM8 and STAT3 are critical for PDAC progression and potential therapeutic targets.
Methods
TGCA, microarray, and immunohistochemistry data from a PDAC cohort were used for clinical analyses. Panc89 cells with ADAM8 knockout, re-expression of ADAM8 mutants, and Panc1 cells overexpressing ADAM8 were generated. Gene expression analyses of ADAM8, STAT3, long non-coding (lnc) RNA NEAT1, miR-181a-5p and ICAM1 were performed by quantitative PCR. Subcellular fractionation quantified NEAT1 expression in cytoplasm and nucleus of PDAC cell lines. Cell proliferation, scratch, and invasion assays were performed to detect growth rate, migration and invasion capabilities of cells. Gain and loss of function experiments were carried out to investigate the biological effects of lncRNA NEAT1 and miR-181a-5p on PDAC cells and downstream genes. Dualluciferase reporter gene assay determined interaction and binding sites of miR-181a-5p in lncRNA NEAT1. Pull down assays, RNA binding protein immunoprecipitation (RIP), and ubiquitination assays explored the molecular interaction between lncRNA NEAT1 and STAT3.
Results
High ADAM8 expression causes aberrant STAT3 signaling and activation of downstream genes in PDAC cells and is positively correlated with NEAT1 expression. NEAT1 binding to STAT3 was confirmed and prevents STAT3 degradation in the proteasome as increased degradation of STAT3 was observed in ADAM8 knockout cells and cells treated with bortezomib. Furthermore, miRNA-181a-5p whose expression is controlled by ADAM8, regulates NEAT1 expression by direct binding to the NEAT1 promoter.
Conclusion
ADAM8 regulates intracellular STAT3 levels via miR-181a-5p and NEAT1 in pancreatic cancer.
Double edge notched tensile testing of PET/ PA blends
Authors: SCHON CLAUDIO , Silva Carlos Fernandes da , Ferreira Nicolas Willy , Santos Alessandra Fernandes 
Published: July 2024

Abstract

Polyethilene Terephtalate, PET, is a versatile thermoplastic commodity widely used in the food and pharmaceutic industries to produce packaging containers. In spite of the recognized advantages, room for improvement, especially in the barrier properties against oxygen transport, require further development. Blending with other polymers is a standard way to modify properties of a base resin, and, in this sense, blending PET with Polyamide, PA, has this potential. Blending of dissimilar polymers however, always raise questions about compatibility and optimal content of the added resin concerning mechanical properties. The present work reports preliminary results of prospecting films of PET and PA, using two PA resins, standard PA 6.6 and PA 6T6I (PA modified with a terephtalate group) in four different contents (2.5, 5, 10 and 20 weight \%) in the form of Double Edge Notched Tensile (DENT) samples. Results show that resin PA 6T6I is more compatible with PET, as expected, but the strength is only slightly affected in the added range of both resins.
Assessing health related quality of life of patients on maintenance hemodialysis in north-western Morocco
Authors: Mourchid Rania , Yassine Amal , Cherrah Yahia , Serragui Samira 
Published: July 2024

Abstract

Objectives
Assess the health-related quality of life (HRQoL) with the aid of EQ-5D-5L dimensions, EQ visual analog scale (VAS) scores in patients receiving hemodialysis treatment in five dialysis centers.
Methods
Multicenter cross sectional observational study was conducted in four different dialysis centers in two Moroccan cities in the north-west region. Validated questionnaires were utilized to collect data on HRQoL using EQ-5D-5L. Binary logistic regression test analysis was conducted to identify the variables which are independently associated with HRQoL among ESRD patients. A 95% confidence interval (p≤0.05) was used to indicate the statistical significance of our results.
Results
The study included a sample of 122 patients undergoing hemodialysis treatment. The median age of study participants was 65.0 (IQR [54.75; 69.0]) years. The mean utility score of EQ-5D-5L was 0.70 (± 0.27) The median EQ-5D-5L utility score and EQ-VAS score was 0.81(IQR [0.52; 0.91]), 70.0 (IQR [60; 79.25]) respectively. Participants reported extreme problems mostly in the mobility domain (9%). In the binary logistic regression analysis, the dimensions of self care and usual activities were positively influenced by the public dialysis sector, one variable which was an increased number of comorbidities negatively impacted the dimension of pain/discomfort, it was found that both the dimensions of mobility and anxiety/depression were not impacted by any variable.
Conclusion
The study emphasizes how patients under dialysis have a relatively good HRQoL. We found a few predictor variables impact HRQol and its dimensions which were the dialysis sector and an elevated number of comorbidities.
Ensemblex: an accuracy-weighted ensemble genetic demultiplexing framework for population-scale scRNAseq sample pooling
Authors: Fiorini Michael R. , Amiri Saeid , Dilliott Allison A. , Ohki Cristine M. Yde , Smigielski Lukasz , Walitza Susanne , Fon Edward A. , Grünblatt Edna , Thomas Rhalena A. , Farhan Sali M.K. 
Published: July 2024

Abstract

Multiplexing samples from distinct individuals prior to sequencing is a promising step toward achieving population-scale single-cell RNA sequencing by reducing the restrictive costs of the technology. Individual genetic demultiplexing tools resolve the donor-of-origin identity of pooled cells using natural genetic variation but present diminished accuracy on highly multiplexed experiments, impeding the analytic potential of the dataset. In response, we introduce Ensemblex: an accuracy-weighted, ensemble genetic demultiplexing framework that integrates four distinct algorithms to identify the most probable subject labels. Using computationally and experimentally pooled samples, we demonstrate Ensemblex’s superior accuracy and illustrate the implications of robust demultiplexing on biological analyses.
Exploring the Analgesic Potential of Cytidine, Uridine, and Gabapentin either alone or in combination: Insights from Formalin-Induced Pain and Diabetic Neuropathy Models
Authors: Qnais Esam , Barakat Muna , Athamneh Rabaa Y. , Al-Najjar Mohammad A. A , Alzaghari Lujain F. , Chellappan Dinesh Kumar , Alqudah Abdelrahim 
Published: July 2024

Abstract

Diabetic neuropathic pain is a usual consequence of diabetes. In this study, the formalin-induced pain and the diabetic neuropathy models were used in mice to investigate if the cytidine, uridine, and gabapentin treatments either alone or in combination can reduce nephropathic pain or not. To achieve our goals, cytidine, uridine, and gabapentin, either alone or in combination were orally administered to mice at a dose of 100 mg/kg. The formalin test was used to examine pain-related behaviors throughout both the primary and secondary phases. Further, the potential pain-relieving efficacy of these therapies was assessed in a diabetic neuropathy model produced by streptozotocin injection. Oral administration of the combination (cytidine + uridine + gabapentin) reduces formalin-induced pain-associated behavior in the first and second phases more than in each treatment alone. In the diabetic neuropathy model, administering the cytidine + uridine + gabapentin combination significantly reversed the pain threshold detected. The combination of cytidine, uridine, and gabapentin decreased as well as the elevated spinal p-CREB levels caused by formalin, which was reversed by pre-treatment with naloxone, yohimbine, and methysergide. This study reveals that the cytidine, uridine, and gabapentin combination have strong synergistic pain-relieving properties in both formalin-induced pain and diabetic neuropathy models more than each treatment alone.
Detection, Classification, Planning and Design of Relics landscape sketch based on Remote Sensing——Lingjiatan National Archaeological Site Park as an example
Authors: Zhu Tiejun , Li Yuan , Huang Xiaoge 
Published: July 2024

Abstract

Remote sensing is the process of detecting and monitoring the physical characteristics of an area by measuring its reflected and emitted radiation at a distance. It can accurately map the geographical location information of the study area and present the surface mountains, rivers and lakes. The intervention of remote sensing big data into the design of landscape sketch in the park is convenient for the observation of the important location nodes of the ruins park. The landscape sketch is placed as a node marker among them, which can guide the visiting route and make the park planning more reasonable and scientific. First of all, the surface information data obtained by the hyperspectral resolution remote sensing is detailed and comprehensive, which ensures the accuracy of the nodes set for the landscape sketch and provides accurate data for the calculation of the sensitivity of the landscape sketch. Secondly, the geological remote sensing detection can be used to identify the tone and pattern of the geological environment, which provides a reference for the selection of color and material for the Landscape sketch. Remote sensing technology is helpful to solve the classification, planning and other problems of landscape sketch in Lingjiatan Site Park, and provides information reference for landscape sketch design. The effective use of remote sensing technology is helpful to design practical and artistic landscape sketch.
Strobilocercus fasciolaris induced hepatic sarcoma in Wistar Rats
Authors: Kumar Rahul , Sudan Vikrant 
Published: July 2024

Abstract

Background Taenia taeniaeformis infects the small intestine of domestic and wild carnivores. Rodents, the intermediate hosts, ingest the gravid proglottids from the carnivores' feces. The parasite’s oncosphere reaches the liver via portal circulation after penetrating the wall of small intestine.
Purpose The present study reports hepatic sarcoma caused by strobilocercus- the metacestodal stage of Taenia taeniformis in laboratory rats.
Method Twenty-three rats in a colony of 72 male wistar rats died suddenly with clinical signs of weakness, lethargy and mild diarrhea. The carcasses were sent to the department of veterinary pathology for postmortem examination.
Results Grossly, the liver of 18 rats were having multiple, cream to white cysts of variable sizes of Strobilocercus fasciolaris. Histopathologically, the hepatic tissue surrounding the cysts revealed zones of fatty change, inflammation with infiltration of plasma cells, macrophages and eosinophils, presence of granulation tissue, metaplasia and fibrosarcoma. The pathological changes in the stomach and small intestines include hyperplasia of gastric and intestinal glands and their mucosa.
Conclusion The likelihood of altered research results of studies conducted in immune-compromised T. taeniformisinfected rats and its zoonotic implications are discussed herewith.
Sea urchin-like Ni 3 (HITP) 2 as the substrate of molecular imprinted polymer: the voltammetric mechanism for sensitive detection of dopamine
Authors: Zhang Xia , Su Jishan , Sun Lili , Ben Yingying , Sun Yizhan , Wei Yajun , Xu Yuandong 
Published: July 2024

Abstract

As a neurotransmitter, dopamine plays an extremely important role in human body. Tracking the amount of dopamine is essential to keep health. An electrochemical sensor composed of conductive metal-organic framework [Ni3(HITP)2] and molecular imprinted polymers (MIP) is fabricated to detect dopamine. Ni3(HITP)2 promotes electrons transfer due to the structure of in-plane charge delocalization and layered expansion conjugation. The combination of MIP with Ni3(HITP)2 improves the selectivity and conductivity, exhibiting a wide detection range (0.06~200 µM) and a lower detection limit (0.109 µM). The kinetic mechanism on the electrode surface is an adsorption controlled process, with the equal number of electrons and protons participating in oxidation in the electrocatalytic process of catechol converting to o-quinone.
Visible-Light-Promoted Direct Desulfurization of Glycosyl Thiols to Access of C-Glycosides
Authors: Ma Xiaofeng , Xie Demeng , Zeng Wei , Yang Jian 
Published: July 2024

Abstract

C-Glycosides are essential for the study of biological processes and the development of carbohydrates-based drugs. Despite tremendous hurdles, glycochemists have often fantasized of the efficient, highly stereoselective synthesis of C-glycosides with the shortest steps under mild conditions. Herein, we report a desulfurative radical protocol to synthesize C-alkyl glycosides and coumarin C-glycosides under visible-light induced conditions without the need of an extra photocatalyst, in which stable and readily available glycosyl thiols that could be obtained in two or three steps from native sugars are activated in situ by pentafluoropyridine. The benefits of this procedure include high stereoselectivity, broad substrates scope, and easily handle. Mechanistic studies indicated that the in situ produced tetrafluoropyridyl S-glycosides formed key EDA complexes with Hantzsch ester (for C-alkyl glycosides) or Et3N (for coumarin C-glycosides), which upon irradiation of visible light, triggered a cascade of glycosyl radical process to access C-glycosides smoothly.
Achieving Adult Status in Greece
Authors: Galanaki Evangelia , Arnett Jeffrey Jensen , Amanaki Eirini 
Published: July 2024

Abstract

The attainment of adult status in Greece is a neglected research issue. Sociodemographic changes and the severity and long duration of the Global Recession in this country (2008-2018) are expected to contribute to the delayed entry to adulthood, especially among university students. In this study, conducted in 2015, 814 university students (ages 18-25; M = 19.9) provided information on subjective adult status (per se and with significant others), achievement of adulthood criteria, associations between the two, and several personal and contextual variables. Results showed that two thirds of the sample felt in-between adolescence and adulthood. They felt more adult in work, university, and romantic relationships, and less adult with parents, friends, and siblings. The most achieved criteria were in the areas of Norm Compliance and Independence, whereas Role Transitions had been achieved the least. A variety of achievements, reflected in Independence, Norm Compliance, and Family Capacities criteria, and some concrete transitions were significantly associated with subjective adult status. Gender, age, parents’ educational level, financial constraints, and financial concerns significantly and differentially predicted the achievement of several adulthood markers. Results provide insight into the achievement of adult status within the Greek context in the aftermath of the Global Recession.
The Sustainability of the Factoring Chain in Europe in the Light of the Integration of ESG Factors
Authors: Arnone Massimo , Leogrande Angelo 
Published: July 2024

Abstract

The competitiveness of financed intermediaries cannot be based exclusively on financial sustainability, i.e. the ability to create profit, but it is also necessary to acquire a transversal vision of sustainability focused on the three ESG dimensions. The paper intends to propose a reflection on the main impacts of the integration of ESG factors on business decisionmaking and operational processes in the financial sector. In this context, we try to understand what role FinTech can play in favor of greater sustainability. Furthermore, through an empirical analysis, some determinants relating to social, environmental, and governance issues are identified which influence the volume of financial resources moved in the factoring market at a European level. Machine learning models are also proposed to estimate the volume
JEL CLASSIFICATION: G00, G2, G21
A Proposed Adaptive Navigation Architecture to Improve Safety of Self-Guided Vehicles in Dynamic Manufacturing Environments.
Authors: GRABA Massinissa , Kelouwani Sousso , Zeghmi Lotfi , Allani Bilel , Amamou Ali , Agbossou Kodjo , Mohammadpour Mohammad 
Published: July 2024

Abstract

Industrial Self-Guided Vehicles (SGVs), a type of Autonomous Mobile Robots (AMRs) used for material handling tasks, have recently attracted increased attention. As logistics scenarios grow more complex, effectively using state-of-the-art navigation algorithms becomes more challenging but essential for enhancing industrial operational efficiency. In recent years, several path and motion planning algorithms have been developed for broad autonomous navigation applications. While classical navigation schemes might seem suitable for automating SGV movement, a thorough evaluation reveals potential performance bottlenecks, especially when multiple SGVs navigate in dynamically evolving manufacturing environments. Deploying a fleet of SGVs in a shared environment complicates navigation safety for different occupants. Therefore, this paper proposes an adaptive architecture suitable for heterogeneous types of SGVs, capable of characterizing and modeling navigation safety. An extensive evaluation of the proposed approach for the SGV-System, aimed at modeling navigation conflicts through the configuration space, is conducted. The assessment highlights safety and energy efficiency benchmarks across various scenarios, including avoiding unpredictable obstacles such as pedestrians and forklifts. Additionally, simulation tests with various local motion planners were conducted to test the reliability of the proposed strategy. The results suggest that adding an adaptive component to the navigation framework, alongside suitable motion planners, enhances the motion performance of the entire fleet of autonomous mobile platforms.
A new approach for explicit approximation of the Colebrook–White formula for pipe flows
Authors: Ferreri Giovanni B. 
Published: July 2024

ABSTRACT
A novel approach is presented for explicit assessment of the friction factor of the Darcy–Weisbach formula for a pipe turbulent flow, a topic being especially useful in practical applications requiring a large number of pipes has to be calculated a great many times in a short time. In such applications, in fact, an explicit formula shortening computation time, with respect to a trial-and-error solution of the Colebrook–White formula, is very advisable. To this aim, in the paper analytical simplicity is pursued besides accuracy, the latter being kept high enough for practical purposes. Unlike previous studies, the ratio between the actual friction factor and that relating to a fully turbulent flow is analysed as a function of the relative roughness and the relative Reynolds number (i.e., the ratio between the actual Reynolds number and the Reynolds number separating the transition regime from the fully turbulent regime). By processing a dataset obtained by systematically solving the C-W formula over suited ranges of the Reynolds number and the relative roughness, two expressions are obtained: a simpler first-step accuracy expression giving generally acceptable accuracy for most engineering practical purposes; and a second-step accuracy expression allowing adequately high accuracy for all situations.
Preparation of low-cost biochar from discarded tea waste for aqueous phase removal of hexavalent chromium [Cr(VI)]: kinetics, isotherm, and recyclability analysis
Authors: Kannaujiya Deepa , Vishwakarma Devesh , Shikha  
Published: July 2024

ABSTRACT

The paper reports the application of iron–Jatropha leaf extract functionalized biochar derived from discarded tea waste to remove hexavalent chromium from aqueous matrices. The surface of the FeJa@TB was prepared from discarded tea waste and was functionalized by FeSO4, FeCl3, and Jatropha leaf extract. The batch mode adsorption experiments with various experimental conditions such as pH, contact time, initial adsorbate concentration, and temperature, were conducted to evaluate the ability of the adsorbent to remove Cr(VI). Kinetics of the sorption were analyzed by fitting the sorption data on various models namely, pseudo-first-order, pseudo-second-order, and intra-particle diffusion models. The kinetic study concluded that chemisorption was the chief mechanism for the adsorptive removal of Cr(VI) as the sorption followed a pseudo-second-order model. Sorption data fitted better to the Freundlich isotherm model, suggesting multilayer Cr(VI) coverage onto the biochar surface. Thermodynamic parameters ΔG°, ΔH°, and ΔS° were computed to observe the influence of temperature on the process of sorption. The study concluded that the adsorptive removal of Cr(VI) onto biochar was non-spontaneous and exothermic with fewer randomness at the solid–liquid interface. The prepared biochar was recyclable up to six times with insignificant removal efficiency loss.
Fine-tuning inflow prediction models: integrating optimization algorithms and TRMM data for enhanced accuracy
Authors: Ali Enas , Zerouali Bilel , Tariq Aqil , Katipoğlu Okan Mert , Bailek Nadjem , Santos Celso Augusto Guimarães , M. Ghoneim Sherif S. , Towfiqul Islam Abu Reza Md. 
Published: July 2024

ABSTRACT
This research explores machine learning algorithms for reservoir inflow prediction, including long short-term memory (LSTM), random forest (RF), and metaheuristic-optimized models. The impact of feature engineering techniques such as discrete wavelet transform (DWT) and XGBoost feature selection is investigated. LSTM shows promise, with LSTM-XGBoost exhibiting strong generalization from 179.81 m3/s RMSE (root mean square error) in training to 49.42 m3/s in testing. The RF-XGBoost and models incorporating DWT, like LSTM-DWT and RF-DWT, also perform well, underscoring the significance of feature engineering. Comparisons illustrate enhancements with DWT: LSTM and RF reduce training and testing RMSE substantially when using DWT. Metaheuristic models like MLP-ABC and LSSVR-PSO benefit from DWT as well, with the LSSVR-PSO-DWT model demonstrating excellent predictive accuracy, showing 133.97 m3/s RMSE in training and 47.08 m3/s RMSE in testing. This model synergistically combines LSSVR, PSO, and DWT, emerging as the top performers by effectively capturing intricate reservoir inflow patterns.
Entre caminhos e ferrovias no subúrbio paulistano:
Authors: Campos Cristina , Castilho Albuquerque Larissa 
Published: July 2024

No final do século XIX, a cidade de São Paulo era circundada por subúrbio constituído por chácaras com fortes características rurais. Situado em tal área estava o bairro do Tatuapé, que surge em meio às rotas terrestres e ferroviárias que ligavam São Paulo com o Rio de Janeiro. Esse estudo tem como objetivo entender a urbanização paulistana pelo caso do Tatuapé por meio de mapas produzidos ao longo do século XX. Os mapas selecionados permitem observar a evolução da mancha urbana e a metamorfose de uma área com características rurais para outra predominantemente urbana. Essa urbanização levou a consolidação de um adensamento horizontal expressivo, característico da periferia paulistana em sua porção leste.