bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating Service Encounters: The Effects of Employee Responses on Service Failure and Recovery
Authors: Tan Tiffany Adelaine G. 
Published: October 2012

Service failure could still happen in spite of management efforts to prevent it. Earlier studies have shown that a service failure can still end up satisfying customers through the efforts of the frontline employees. This empirical study investigates how the performance of the frontline employees affects customer satisfaction after a service recovery, specifically, customer’s propensity to recommend the service firm. The primary purpose of the study is to determine whether the same dimensions that affect perceived service quality (namely, reliability, assurance, responsiveness, empathy and tangibility) of a service performance also applies to service recovery performance evaluation. Using confirmatory factor analysis on the items of SERVPERF, results showed that a customer who was satisfied with the service employee’s performance on the recovery process will most probably recommend the service firm to others even after a service failure. The results also indicate that while the service quality items are all significantly different from zero, only the reliability and assurance dimensions meaningfully affect the customer’s satisfaction during the recovery process. It seems that, for this study, not all of the dimensions in the SERVPERF survey that affect perceived service quality of a service performance also apply to service recovery evaluation. Keywords - service failure, service recovery, frontline employees, assurance, Philippines
Biomarkers of Cellular Senescence and Aging: Current State‐of‐the‐Art, Challenges and Future Perspectives
Authors: Muthamil Subramanian , Kim Hyun‐Yong , Jang Hyun‐Jun , Lyu Ji‐Hyo , Shin Ung Cheol , Go Younghoon , Park Seong‐Hoon , Lee Hee Gu , Park Jun Hong 
Published: June 2024

AbstractPopulation aging has increased the global prevalence of aging‐related diseases, including cancer, sarcopenia, neurological disease, arthritis, and heart disease. Understanding aging, a fundamental biological process, has led to breakthroughs in several fields. Cellular senescence, evinced by flattened cell bodies, vacuole formation, and cytoplasmic granules, ubiquitously plays crucial roles in tissue remodeling, embryogenesis, and wound repair as well as in cancer therapy and aging. The lack of universal biomarkers for detecting and quantifying senescent cells, in vitro and in vivo, constitutes a major limitation. The applications and limitations of major senescence biomarkers, including senescence‐associated β‐galactosidase staining, telomere shortening, cell‐cycle arrest, DNA methylation, and senescence‐associated secreted phenotypes are discussed. Furthermore, explore senotherapeutic approaches for aging‐associated diseases and cancer. In addition to the conventional biomarkers, this review highlighted the in vitro, in vivo, and disease models used for aging studies. Further, technologies from the current decade including multi‐omics and computational methods used in the fields of senescence and aging are also discussed in this review. Understanding aging‐associated biological processes by using cellular senescence biomarkers can enable therapeutic innovation and interventions to improve the quality of life of older adults.
Fluoride Substitution: Quantifying Surface Hydroxyls of Metal Oxides with Fluoride Ions
Authors: Lau Kinran , Zerebecki Swen , Pielsticker Lukas , Hetaba Walid , Dhaka Kapil , Exner Kai S. , Reichenberger Sven , Barcikowski Stephan 
Published: June 2024

AbstractSurface hydroxyls (OH) are crucial for heterogeneous catalysis in water. However, they are commonly characterized at solid–gas interfaces (e.g., FTIR, XPS, TGA), which may not represent the surface in aqueous environments. Here, the surface OH of five catalytically relevant oxides (Al2O3, ZrO2, TiO2, Fe2O3, Co3O4) are quantified by substituting them with F− ions at pH 3–10, where the surface fluoride (F) density is evaluated by XPS using the geometry factor for spherical particles. These results show that the surface F density peaks at around pH 4 across all oxides, but decreases at more basic pH due to increased OH− competition. Generally, oxides more abundant in surface OH can also accommodate more surface F, establishing F− ions as effective probes. While terminal F are likely the preferential substitution product, bridging F also appear to form at lower pH levels. Furthermore, fluoride substitution is applied to a series of Co3O4 gradually enriched with defects using pulsed laser defect engineering in liquid (PUDEL). This approach reveals a linear correlation between laser processing and surface OH density, which aligns with a previously observed improvement in OER activity, and is supported by additional DFT calculations here. This work will stimulate further studies adopting fluoride substitution to better understand the relationship between surface chemistry and catalytic processes in aqueous environments.
A Cryopreservation Strategy for Myoblast Storage in Paper‐Based Scaffolds for Inter‐Laboratory Studies of Skeletal Muscle Health
Authors: Rjaibi Saifedine T. , Jacques Erik , Ni Jiaru , Xu Bin , Kouthouridis Sonya , Sitolle Julie , Lad Heta , Gulati Nitya , Li Nancy T. , Ahn Henry , Ginsberg Howard J. , Zhang Boyang , Grand Fabien Le , Gilbert Penney M. , McGuigan Alison P. 
Published: June 2024

Abstract3D tissue‐engineered models are poised to facilitate understanding of skeletal muscle pathophysiology and identify novel therapeutic agents to improve muscle health. Adopting these culture models within the broader biology community is a challenge as many models involve complex methodologies and significant investments of time and resources to optimize manufacturing protocols. To alleviate this barrier, a protocol with commercially available reagents is developed to cryopreserve myoblasts in a 96‐well compatible format that allows tissues to be transferred to users without expertise in 2D or 3D skeletal muscle cell culture. This report validates that myoblasts encapsulated in a hydrogel and cryopreserved in paper‐based scaffolds maintain cell viability, differentiation, and function via acetylcholine‐induced transient calcium responses. Furthermore, successful shipping of myoblasts cryopreserved in paper‐based scaffolds to intra‐provincial and international collaborators is demonstrated who successfully thaw, culture, and use the 3D muscle tissues. Finally, the application of this method is confirmed for studying muscle endogenous repair by seeding freshly isolated skeletal muscle stem cells to cryopreserved then differentiated and injured tissues, demonstrating expected responses to a known stimulator of muscle stem cell self‐renewal, p38α/β MAPKi. Altogether, the 3D myoblast cryopreservation protocol offers broadened access of a complex skeletal muscle tissue model to the research community.
Recrystallization Strategy for Efficient Preparation of Metal Halide Single Crystals with High‐Quality
Authors: Yun Xiangyan , Zhou Bo , Hu Hanlin , Zhong Haizhe , Xu Denghui , Li Henan , Shi Yumeng 
Published: June 2024

AbstractLarge size high‐quality perovskite single‐crystals are highly desirable for investigating their fundamental materials properties and realizing state of the art electronic/optoelectronic device performance. Herein, a novel single‐crystal growth method is reported by recrystallization of perovskites in oversaturated solutions. Perovskite single crystals including both organic–inorganic hybrid metal halides and their all‐inorganic counterparts can be obtained in large amounts by this method. All of the synthesized perovskite single crystals exhibit large crystal sizes (centimeter level) and exceptional light emission properties. Meanwhile, the single‐crystal growth can be well controlled and the solvent can be reused for cycles of single‐crystal growth, which sheds light on the preparation of perovskite materials in a way of green chemistry. In addition, thermodynamic growth principles for the single‐crystal growth are proposed, providing a universal approval for metal halide single‐crystal synthesis.
Alzheimer's disease biomarker burden in primary motor cortices is associated with poorer dexterity performance
Authors: Gupta Lily , Ma Yue , Kohli Akshay , Yang Kao Lee , Oh Jennifer M. , Betthauser Tobey J. , Chin Nathaniel A. , Okonkwo Ozioma C. , Pasquesi Mary‐Elizabeth , Nair Veena , Prabhakaran Vivek , Li Shi‐Jiang , Bendlin Barbara 
Published: June 2024

AbstractINTRODUCTIONMotor function has correlated with longevity and functionality; however, there is limited research on those with Alzheimer's disease (AD). We studied the association between motor functionality and AD pathology in primary motor and medial temporal cortices.METHODSA total of 206 participants with a clinical diagnosis of cognitively healthy, AD, or mild cognitive impairment (MCI) underwent imaging and motor assessment. Linear regressions and analyses of variance were applied to test the prediction from AD imaging biomarkers to motor performance and the diagnosis group differences in motor performance.RESULTSIncreased neurodegeneration was associated with worsening dexterity and lower walking speed, and increased amyloid and tau were associated with worsening dexterity. AD and MCI participants had lower motor performance than the cognitively healthy participants.DISCUSSIONIncreased AD pathology is associated with worsening dexterity performance. The decline in dexterity in those with AD pathology may offer an opportunity for non‐pharmacological therapy intervention.Highlights
Noted worsening dexterity performance was associated with greater Alzheimer's disease (AD) pathology (tau, amyloid beta, and neurodegeneration) in primary motor cortices.
Similarly, increased neurodegeneration and tau pathology in parahippocampal, hippocampal, and entorhinal cortices is associated with worsening dexterity performance.
Motor performance declined in those with clinical and preclinical AD among an array of motor assessments.
Neighborhood racial income inequality and cognitive health
Authors: Zahodne Laura B. , Sol Ketlyne , Scambray Kiana , Lee Ji Hyun , Palms Jordan D. , Morris Emily P. , Taylor Lauren , Ku Vivian , Lesniak Mary , Melendez Robert , Elliott Michael R. , Clarke Philippa J. 
Published: June 2024

AbstractINTRODUCTIONNeighborhood socioeconomic status (SES) has been linked to dementia, but the distribution of SES within a neighborhood may also matter.METHODSData from 460 (47% Black, 46% White) older adults from the Michigan Cognitive Aging Project were linked to census tract–level data from the National Neighborhood Data Archive (NaNDA). Neighborhood SES included two composites reflecting disadvantage and affluence. Neighborhood racial income inequality was the ratio of median incomes for White versus Black residents. Generalized estimating equations examined associations between neighborhood factors and cognitive domains.RESULTSNeighborhood racial income inequality was uniquely associated with worse cognitive health, and these associations did not differ by participant race. Neighborhood disadvantage was only associated with worse cognitive health among Black participants.DISCUSSIONBoth the level and racial distribution of SES within a neighborhood may be relevant for dementia risk. Racial differences in the level and impact of neighborhood SES contribute to dementia inequalities.Highlights
Black participants lived in neighborhoods with lower socioeconomic status (SES) than White participants, on average.
Neighborhood SES and racial income inequality were associated with worse cognition.
Effects of neighborhood racial income inequality did not differ across racial groups.
Effects of neighborhood SES were only evident among Black participants.
The ketamine metabolite (2R,6R)‐hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease
Authors: Ribeiro Felipe C. , Cozachenco Danielle , Argyrousi Elentina K. , Staniszewski Agnieszka , Wiebe Shane , Calixtro Joao D. , Soares‐Neto Rubens , Al‐Chami Aycheh , Sayegh Fatema El , Bermudez Sara , Arsenault Emily , Cossenza Marcelo , Lacaille Jean‐Claude , Nader Karim , Sun Hongyu , De Felice Fernanda G. , Lourenco Mychael V. , Arancio Ottavio , Aguilar‐Valles Argel , Sonenberg Nahum , Ferreira Sergio T. 
Published: June 2024

AbstractINTRODUCTIONImpaired brain protein synthesis, synaptic plasticity, and memory are major hallmarks of Alzheimer's disease (AD). The ketamine metabolite (2R,6R)‐hydroxynorketamine (HNK) has been shown to modulate protein synthesis, but its effects on memory in AD models remain elusive.METHODSWe investigated the effects of HNK on hippocampal protein synthesis, long‐term potentiation (LTP), and memory in AD mouse models.RESULTSHNK activated extracellular signal‐regulated kinase 1/2 (ERK1/2), mechanistic target of rapamycin (mTOR), and p70S6 kinase 1 (S6K1)/ribosomal protein S6 signaling pathways. Treatment with HNK rescued hippocampal LTP and memory deficits in amyloid‐β oligomers (AβO)‐infused mice in an ERK1/2‐dependent manner. Treatment with HNK further corrected aberrant transcription, LTP and memory in aged APP/PS1 mice.DISCUSSIONOur findings demonstrate that HNK induces signaling and transcriptional responses that correct synaptic and memory deficits in AD mice. These results raise the prospect that HNK could serve as a therapeutic approach in AD.Highlights
The ketamine metabolite HNK activates hippocampal ERK/mTOR/S6 signaling pathways.
HNK corrects hippocampal synaptic and memory defects in two mouse models of AD.
Rescue of synaptic and memory impairments by HNK depends on ERK signaling.
HNK corrects aberrant transcriptional signatures in APP/PS1 mice.
Comparative morphological, thermal, and mechanical characteristics of doped bentonite and dolomite natural clay fillers into high‐density polyethylene
Authors: Mahmoud Mohamed E. , Khalifa Mohammed A. , Youssef Mahues R. , El‐Sharkawy Rehab M. 
Published: June 2024

AbstractOrganic–inorganic composites have attracted great interest, due to their remarkable impact, causing improvements in the mechanical properties of polymers when compared with their pure forms. Hence, this study has been attempted to investigate and compare the various properties of high‐density polyethylene (HDPE), separately doped with two different types of clay minerals using melt‐mixing and compression‐molding techniques. The fourier transform infrared spectroscopy (FT‐IR), x‐ray diffraction (XRD), and scanning electron microscope (SEM) were used to characterize the structural and morphological properties of the resulting composites, while, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were employed to characterize their thermal properties. Morphological investigations indicated homogeneous dispersion of both clay materials in the HDPE matrix. Moreover, an investigation was conducted on the mechanical properties of composites, including elastic modulus, yield stress, tensile strain at break, tensile strain at yield, tensile stress at break, and ultimate tensile strength. According to the mechanical data, adding 6.0 wt% of bentonite or dolomite to HDPE led to an increase in the elastic modulus up to 125% and 116% increments, respectively. An increase in the filler content in the composite from 2.0 to 8.0 wt% resulted in a slight decrease in tensile stress at break, yield stress, tensile strain at break, and tensile strain at yield.
Biodegradable polybutylene adipate terephthalate foams: Investigating sustainability via reprocessing and green solvent
Authors: de Macedo Rooweder Lima Guilherme , Hobbenschot Simon F. H. , Mukherjee Adrivit , Parisi Daniele , Picchioni Francesco , Bose Ranjita K. 
Published: June 2024

AbstractIncorporating reprocessing, recycling, and sustainable processes and materials is essential for a circular economy. Reprocessing and recycling are related since both help minimize wastage and produce a sustainable regenerative economy. However, polymers might undergo degradation depending on the recycling process, reducing their lifespan. In this study, polybutylene adipate terephthalate (PBAT) undergoes repetitive reprocessing under varied temperatures, times, and shear rates to investigate the evolution of mechanical, chemical, and thermal properties. Furthermore, foaming experiments are conducted using supercritical carbon dioxide (scCO2) on reprocessed samples to examine changes in the properties and morphology of the foam. The significance of reprocessing PBAT is divided into environmental, temperature, and processing effects. Environmental conditions impact the results where no oxidation effects are noticed in the 2‐hour test, while 7 days of humidity exposure lead to a tenfold reduction in polymer viscosity. Different processing techniques reduce the molecular weight of PBAT and alter its polydispersity. Specifically, the number average molecular weight (Mn) decreases from an initial 53 to 37 kDa after processes like extrusion or mixing. However, elongation at break and ultimate strength of PBAT remain unchanged after high‐shear extrusion processing. Additionally, PBAT foam morphology evolves over 5 cycles, leading to smaller pores and reducing compressive modulus.
Liquid chromatography–tandem mass spectrometry for determination of fingolimod and its active metabolite fingolimod phosphate in whole blood of patients with multiple sclerosis
Authors: Pesakova Veronika , Brozmanova Hana , Sistik Pavel , Kusnirikova Zuzana , Kacirova Ivana , Grundmann Milan 
Published: June 2024

AbstractFingolimod is an oral drug for the escalation of treatment of relapsing–remitting multiple sclerosis in patients with persistent disease activity on first‐line drugs or in patients with rapidly progressive severe relapsing–remitting multiple sclerosis. An ultra‐high‐performance liquid chromatography–tandem mass spectrometry method for determining the concentrations of fingolimod and its active metabolite fingolimod phosphate in whole blood has been developed and validated. The advantages of this method are the easy, fast and cheap sample preparation using protein precipitation from blood with a mixture of acetonitrile–methanol (40:60, v/v). Chromatographic separation was performed on a ultra‐high performance liquid chromatography BEH C18 1.7 μm (100 × 2.1 mm) column. Two modes of ionization, electrospray ionization and atmospheric pressure chemical ionization, were tested and compared. For validation, the electrospray ionization mode was chosen. As internal standard, isotopically labeled fingolimod‐D4 was used to quantify the analytes. The method was validated according to the rules of the European Medicines Agency. The coefficients of variation for fingolimod were in the range of 1.13–11.88%, and the recovery was 98.80–106.00%. The coefficients of variation for fingolimod phosphate were in the range of 2.73–9.31%, and the recovery was 90.08–107.00%. The method is quite easy and fast and can be used for routine analysis.
Optimizing Air Separation and LNG Cold Utilization: Energy Savings, Exergy Efficiency, and System Reliability
Authors: Shingan Bhalchandra , Pujari Murali , Arya Adarsh Kumar , Singh Varunpratap 
Published: June 2024

AbstractAir separation processes are time‐consuming and energy‐intensive. Most of the energy used in air separation unit (ASU) is used for air compression. During the air compression process, some energy is lost, which is converted into waste heat. This wasted energy is used to warm liquefied natural gas (LNG). At some point, LNG ships will dock at an LNG regasification facility. Here, LNG is converted back to gas and supplied to the distribution and transmission systems. During the regasification process, cryogenic LNG has a huge opportunity for cold energy recovery. An innovative air separation process that is integrated with the cold utilization of LNG is presented in this study along with a thorough conceptual design and analysis. The results of this study show that producing high‐purity oxygen and nitrogen, respectively, requires 0.28 kWh kg−1 and 0.06 kWh kg−1 of specific energies. Prior to integration with cold utilization of natural gas, 25 141.6 kW is needed for air compression. However, following integration, 10 554.6 kW of energy is needed, resulting in a 58.01 % energy savings. Exergy destruction as well as efficiency have been calculated for the primary components of the system. Sensitivity analysis is carried out to examine the effects of LNG streams on important parameters. In conclusion, a cryogenic ASU is integrated with an LNG‐direct expansion cycle‐organic Rankine cycle power cycle to supply the necessary power for operation and reduce extraneous power inputs. Overall, this integrated approach increases efficiency, lowers costs, benefits the environment, allows for flexibility and adaptability, and raises system dependability.
Mapping the structure and chemical composition of MAX phase ceramics for their high‐temperature tribological behaviors
Authors: Yu Hong , Xue Lili , Xue Yaqing , Lu Haoting , Liu Yuxin , Wang Long , Du Cheng‐Feng , Liu Weimin 
Published: June 2024

AbstractMAX phase ceramics is a large family of nanolaminate carbides and nitrides, which integrates the advantages of both metals and ceramics, in general, the distinct chemical inertness of ceramics and excellent physical properties like metals. Meanwhile, the rich chemical and structural diversity of the MAXs endows them with broad space for property regulation. Especially, a much higher self‐lubricity, as well as wear resistance, than that of traditional alloys and ceramics, has been observed in MAXs at elevated temperatures in recent decades, which manifests a great application potential and sparks tremendous research interest. Aiming at establishing a correlation among structure, chemical composition, working conditions, and the tribological behaviors of MAXs, this work overviews the recent progress in their high‐temperature (HT) tribological properties, accompanied by advances in synthesis and structure analysis. HT tribological‐specific behaviors, including the stress responses and damage mechanism, oxidation mechanism, and wear mechanism, are discussed. Whereafter, the tribological behaviors along with factors related to the tribological working conditions are discussed. Accordingly, outlooks of MAX phase ceramics for future HT solid lubricants are given based on the optimization of present mechanical properties and processing technologies.
Design of Triphenylamine‐based D‐π‐A Systems for Efficient Ternary WORM Memory Devices
Authors: Gayathri Ramesh , Akshaya Madanan , Imran Predhanekar Mohamed , Nagarajan Samuthira 
Published: June 2024

AbstractThe impact of various substituent moieties on the molecular framework of a conjugated D−A system in resistive switching memory property has been scrutinized through an array of novel D‐π‐A molecules. The synthesized molecules with triphenylamine (TPA) as the electron donor and dicyanovinylindanone (IC) as the electron acceptor demonstrated substantial non‐volatile WORM (Write‐Once Read‐Many) memory behaviour with appreciable ON/OFF current ratios up to 105 and a lowest recorded threshold voltage of −0.80 V. The well‐balanced combination of these potent electron donating and accepting units culminated in exceptional intramolecular charge transfer interactions and minimal band gap values (1.82–2.31 eV) for the molecules, as demonstrated by photophysical and electrochemical investigations. These factors, coupled with the thin‐film morphological studies, corroborated the superior performance of the fabricated devices. A longer retention time of 2000s and an endurance of 100 cycles mark the substantial stability of the memory devices. Moreover, conversion from binary to ternary WORM memory was achieved by the effective tuning of the electronic properties of the D−A systems by various substituent moieties. Molecular simulation studies revealed that the resistive switching phenomenon arises from a synergistic interplay of charge transfer and charge trapping processes within these D−A systems.