bluuebunny/crossref_metadata_2025_split huggingface dataset:
Review, Historical Context, and Clarifications of the NINDS rt-PA Stroke Trials Exclusion Criteria
Authors: Levine Steven R. , Khatri Pooja , Broderick Joseph P. , Grotta James C. , Kasner Scott E. , Kim Doojin , Meyer Brett C. , Panagos Peter , Romano Jose , Scott Phillip 
Published: July 2013

Background and Purpose—
Since Food and Drug Administration approval of intravenous tissue-type plasminogen activator (tPA) for treatment of acute ischemic stroke in 1996, it has become clear that several criteria used for exclusion from therapy were not based on actual data or operationally defined for use in clinical practice. All eligibility criteria from the National Institute of Neurological Disorders and Stroke (NINDS) recombinant tPA Stroke Study were adopted within the alteplase package insert as contraindications/warnings. Many clinicians have expressed the need for clarification and better definition of these treatment criteria.

Methods—
A group of investigators who also practice as stroke physicians convened a collaborative endeavor to work toward developing more clinically meaningful and consensus-driven exclusion criteria for intravenous tPA. The first of these exclusion criteria chosen was rapidly improving stroke symptoms (RISS). We reviewed and clarified the historical context and intention with the original investigators, held e-mail discussions, convened an in-person RISS Summit, and obtained the understanding of experienced stroke physicians broadly.

Results—
Historically, the intent of this exclusion criterion within the NINDS recombinant tPA Stroke Trial was to avoid treatment of transient ischemic attacks—who would have recovered completely without treatment. There was unanimous consensus that, in the absence of other contraindications, patients who experience improvement of any degree, but have a persisting neurological deficit that is potentially disabling, should be treated with intravenous tPA. This statement is supported from the methods established for the original NINDS trial, on the basis of detailed discussions and interviews with the former NINDS trialists. It was agreed that improvement should only be monitored for the extent of time needed to prepare and administer the intravenous tPA bolus/infusion. An explicit operational definition of RISS was developed by consensus to guide future decision making in acute stroke. There was unanimous agreement that all neurological deficits present at the time of the treatment decision should be considered in the context of individual risk and benefit, as well as the patient’s baseline functional status.

Conclusions—
A structured framework and quantitative approach toward defining RISS emerged through expert opinion and consensus. The term, RISS, should be reserved for those who improve to a mild deficit, specifically one which is perceived to be nondisabling. This is recommended to guide decision making on intravenous tPA eligibility going forward, including the design of future studies. An additional study of patients with rapid improvement to nonmild deficits is not justified because these patients should be treated.
Analytical Philosophy and the Philosophy of Intellectual History: A Critical Comparison and Interpretation
Authors: Skodo Admir 
Published: July 2013

Abstract
This article argues that the relationship between analytical philosophy and the philosophy of intellectual history is conceptually uneasy and even antagonistic once the general philosophical viewpoints, and some particular topics, of the two perspectives are drawn out and compared. The article critically compares the philosophies of Quentin Skinner and Mark Bevir with the philosophies of Ludwig Wittgenstein, J.L. Austin, W.V.O. Quine and Donald Davidson. Section I compares the way in which these two perspectives view the task of philosophy. Section II points to a critical difficulty in Bevir and Skinner’s use of analytical philosophy in their discussions on objectivity. In section III, another such critical juncture is identified in the topic of explanation. Finally, section IV suggests an interpretation for the character of the comparison.
Semantics of Historical Representation in Terms of Aspects
Authors: Zeleňák Eugen 
Published: July 2013

Abstract
In his latest book, Frank Ankersmit proposes an original theory of historical representation. In this review I focus on what I take to be his most important semantic points with respect to representation, meaning, truth, and reference. First, I provide a short summary of the book. Second, I explore his semantics in terms of aspects and compare it with a different account inspired by the Fregean notion of mode of presentation. As my examination shows, Ankersmit’s analysis faces the problem of “loosing indirectness” and, moreover, there seems to exist an alternative and plausible view that does not suffer from this problem. Finally, I conclude with a couple of comments on the Copernican Revolution advocated in the book.
Two Contrasting Severe Seasonal Extremes in Tropical South America in 2012: Flood in Amazonia and Drought in Northeast Brazil
Authors: Marengo Jose A. , Alves Lincoln M. , Soares Wagner R. , Rodriguez Daniel A. , Camargo Helio , Riveros Marco Paredes , Pabló Amelia Diaz 
Published: July 2013

AbstractTwo simultaneous extreme events affected tropical South America to the east of the Andes during the austral summer and fall of 2012: a severe drought in Northeast Brazil and intense rainfall and floods in Amazonia, both considered records for the last 50 years. Changes in atmospheric circulation and rainfall were consistent with the notion of an active role of colder-than-normal surface waters in the equatorial Pacific, with above-normal upward motion and rainfall in western Amazonia and increased subsidence over Northeast Brazil. Atmospheric circulation and soil moisture anomalies in the region contributed to an intensified transport of Atlantic moisture into the western part of Amazonia then turning southward to the southern Amazonia region, where the Chaco low was intensified. This was favored by the intensification of subtropical high pressure over the region, associated with an anomalously intense and northward-displaced Atlantic high over a relatively colder subtropical South Atlantic Ocean. This pattern observed in 2012 was not found during other wet years in Amazonia such as 1989, 1999, and 2009. This suggests La Niña as the main cause of the abundant rainfall in western Amazonia from October to December, with wet conditions starting earlier and remaining until March 2012, mostly in northwestern Amazonia. The anomalously high river levels during the following May–July were a consequence of this early and abundant rainy season during the previous summer. In Northeast Brazil, dry conditions started to appear in December 2011 in the northern sector and then extended to the entire region by the peak of the rainy season of February–May 2012.
An Artificial Neural Network Model to Reduce False Alarms in Satellite Precipitation Products Using MODIS and CloudSat Observations
Authors: Nasrollahi Nasrin , Hsu Kuolin , Sorooshian Soroosh 
Published: July 2013

AbstractThe Moderate Resolution Imaging Spectroradiometer (MODIS) instrument aboard the NASA Earth Observing System (EOS) Aqua and Terra platform with 36 spectral bands provides valuable information about cloud microphysical characteristics and therefore precipitation retrievals. Additionally, CloudSat, selected as a NASA Earth Sciences Systems Pathfinder satellite mission, is equipped with a 94-GHz radar that can detect the occurrence of surface rainfall. The CloudSat radar flies in formation with Aqua with only an average of 60 s delay. The availability of surface rain presence based on CloudSat together with the multispectral capabilities of MODIS makes it possible to create a training dataset to distinguish false rain areas based on their radiances in satellite precipitation products [e.g., Precipitation Estimation from Remotely Sensed Information Using Artificial Neural Networks (PERSIANN)]. The brightness temperatures of six MODIS water vapor and infrared channels are used in this study along with surface rain information from CloudSat to train an artificial neural network model for no-rain recognition. The results suggest a significant improvement in detecting nonprecipitating regions and reducing false identification of precipitation. Also, the results of the case studies of precipitation events during the summer and winter of 2007 over the United States show an accuracy of 77% no-rain identification and 93% detection accuracy, respectively.
Urbanization and Climate Change: An Examination of Nonstationarities in Urban Flooding
Authors: Yang Long , Smith James A. , Wright Daniel B. , Baeck Mary Lynn , Villarini Gabriele , Tian Fuqiang , Hu Heping 
Published: July 2013

Abstract
The authors examine the hydroclimatology, hydrometeorology, and hydrology of flooding in the Milwaukee metropolitan region of the upper midwestern United States. The objectives of this study are 1) to assess nonstationarities in flood frequency associated with urban transformation of land surface properties and climate change and 2) to examine how spatial heterogeneity in land surface properties and heavy rainfall climatology interact to determine floods in urbanizing areas. The authors focus on the Menomonee River basin, which drains much of the urban core of Milwaukee, and the adjacent Cedar Creek basin, where agricultural land use dominates. Results are based on analyses of bias-corrected, high-resolution (1-km2 spatial resolution and 15-min time resolution) radar rainfall fields that are developed using the Hydro-NEXRAD system, rainfall observations from a network of 21 rain gauges in the Milwaukee metropolitan region, and discharge observations from 11 U.S. Geological Survey stream gauging stations. Both annual flood peak magnitudes and annual peaks over threshold flood counts have increased for the Menomonee River basin during the past five decades, and these trends are accompanied by a transition of flood events dominated by snowmelt (March–April floods) to a regime in which warm season thunderstorms are the dominant flood-producing agents. The frequency of heavy rainfall events has increased significantly. The spatial distribution of rainfall for flood-producing storms in the Milwaukee study region exhibits striking spatial heterogeneity, with a maximum in the central portion of the Menomonee River basin. Storm event hydrologic response is determined by the interactions of spatial patterns of urbanization and rainfall distribution in the Menomonee River basin.
Improved Passive Microwave Retrievals of Rain Rate over Land and Ocean. Part II: Validation and Intercomparison
Authors: Petty Grant W. , Li Ke 
Published: July 2013

Abstract
A new passive microwave rainfall retrieval algorithm for the Tropical Rainfall Measuring Mission (TRMM) Microwave Imager (TMI) that relies on an a priori database derived from matchups between TMI brightness temperatures and precipitation radar (PR)-derived surface rain rates has been developed. In addition to implementing a fairly conventional Bayesian approach to precipitation estimation, it exploits a dimensional reduction technique designed to increase the effective sample density in the database and also to improve the detectability of precipitation over problem surface types. The details of the algorithm itself are described in a companion paper. In this paper, the algorithm is validated against independent PR–TMI matchups from calendar year 2002. The validation results are benchmarked against results obtained for the same scenes from the current standard (version 7) 2A12 rainfall product for TRMM.
Validation statistics considered include the biases, correlation coefficients, and root-mean-square (RMS) differences for annual precipitation totals on a 1° grid as well as two-threshold Heidke skill scores (HSS) for instantaneous (pixel level) retrievals, determined separately for each of seven surface classes, including ocean, coast, and five other basic land surface types as well as for cold (&lt;275 K) and warm surface skin temperatures.
Overall, the University of Wisconsin (UW) algorithm exhibits markedly reduced RMS error and bias in the annual total rainfall and markedly improved instantaneous skill at delineating light rain rates, especially over land and the coast. To ensure that the improved results were not due to both the training and validation data having been taken from the same calendar year, the validation of the UW algorithm is repeated using 2005 matchup data.
Plasma Gel as a New Augmentation Material for Injection Laryngoplasty in Rabbit Model: Histologic Analysis
Authors: Hong Seok Jin , Lee Sang Hyuk , Jin Sung Min , Lee Seon Uk , Huh Se Hyung , Kim Dong Hoon , Kwon Soon Young , Woo Seung Hoon 
Published: July 2013

ObjectivesCurrently, a variety of materials are available for the treatment of glottal insufficiency. Ideal injection materials should be inexpensive, easily obtainable, nontoxic, and biocompatible. Plasma gel has recently been developed as an injectable, autologous material used in plastic surgery. The aim of this study was to evaluate the histological changes in rabbit vocal folds (VFs) after an injection of plasma gel, compared with collagen (Artecoll) or hyaluronic acid (Reviderm Intra).Study DesignExperimental prospective animal study.SettingAnimal laboratory.Subjects and MethodsBlood samples were collected from 12 New Zealand rabbits. Plasma collected from each rabbit was centrifuged and processed using a gel heating system. All rabbits received a 0.05 ml injection of plasma gel into the right VF, while an equivalent volume of Artecoll or Reviderm Intra was injected into the left VFs of each 6 rabbits randomly. The larynges were collected 2, 4, and 8 weeks after injection, and the tissues were stained for histological analysis.ResultsIn comparison with left VFs injected with Artecoll or Reviderm Intra, there was significantly less inflammatory response and foreign body reaction in the plasma gel injected right VFs (P <. 05). Multinucleated foreign body type giant cells were also more prevalent in the left VFs. There were no quantitative differences in the rates of neovascularization or collagen deposition between groups.ConclusionPlasma gel is a biologically compatible material that may serve as a suitable augmentation material in injection laryngoplasty. Further studies that examine the long‐term effects in a larger number of subjects are needed.
ERCC1 Protein Expression Is Associated with Differential Survival in Oropharyngeal Head and Neck Squamous Cell Carcinoma
Authors: Patel Mihir R. , Zhao Ni , Ang Mei‐Kim , Stadler Michael E. , Fritchie Karen , Weissler Mark C. , Zanation Adam M. , Harris Stephen L. , Funkhouser William K. , Olshan Andrew F. , Shores Carol G. , Hayes D. Neil 
Published: July 2013

ObjectiveTo investigate ERCC1 protein expression and its relationship to clinical factors and treatment outcomes in patients with head and neck squamous cell carcinoma (HNSCC).DesignCase series.SettingTertiary care academic center.SubjectsOne hundred and seventy‐six patients diagnosed with HNSCC and treated with intent to cure between 2002 and 2008 were analyzed with respect to clinical data and tumor pathology.Main Outcome MeasuresTissue microarrays were constructed from tumor blocks and immunohistochemical staining for ERCC1 performed. ERCC1 expression status was dichotomized into high and low using the Allred score. Clinical characteristics of patients with high versus low ERCC1 expression were compared. Distributions of overall survival (OS) and progression‐free survival (PFS) were analyzed using the Kaplan‐Meier method.ResultsOf 176 patients, ERCC1 showed baseline nuclear staining in 148 patients (84.1%). Lower staining intensity ERCC1 expression was prominent in parabasal cells in the lower half of the epithelium, while at high staining intensity, ERCC1 expression was present throughout the epithelium. The median H‐score was 50. No significant differences in age, gender, smoking status, tumor site, or stage were seen between the high and low ERCC1 expression groups. Expression of ERCC1 stratified by tumor site correlates with OS. Patients with oropharyngeal HNSCC and high ERCC1 expression (H‐score > 120) were more likely to survive (P <. 01) and remain disease free when compared to non‐oropharyngeal squamous cell carcinoma (SCCa) patients with high ERCC1 expression despite treatment modality and human papillomavirus virus (HPV) status.ConclusionPatients with oropharyngeal SCCa and high ERCC1 expression may have better outcomes despite HPV status.
Congenital heart surgery outcome analysis: Indian experience
Authors: Vasdev Sumit , Chauhan Sandeep , Malik Madhur , Talwar Sachin , Velayoudham Devagourou , Kiran Usha 
Published: July 2013

Background The study aimed to analyze the outcome of congenital heart surgery in a subset of Indian patients, using the Aristotle Basic Complexity score, the Risk Adjustment for Congenital Heart Surgery categories, and the Society of Thoracic Surgeons and European Association for Cardiothoracic Surgery mortality categories. Patients and methods 1312 patients <18 years of age undergoing congenital heart surgery were assigned the 3 scores and studied for outcome indices of difficulty (cardiopulmonary bypass time or duration of surgery >120 min), morbidity (intensive care unit stay >7 days), and mortality. Results The overall mortality was 6.85%, with mean a Aristotle Basic Complexity score, Risk Adjustment for Congenital Heart Surgery category, and Society of Thoracic Surgeons and European Association for Cardiothoracic Surgery mortality category of 7.17 ± 2.04, 2.28 ± 0.78, and 2.24 ± 1.06, respectively. The mortality predictive capacity of the Risk Adjustment for Congenital Heart Surgery category (c = 0.76) was similar to that of the Society of Thoracic Surgeons and European Association for Cardiothoracic Surgery mortality category (c = 0.75); both were better compared to the Aristotle Basic Complexity score (c = 0.66). The Risk Adjustment for Congenital Heart Surgery category and Aristotle Basic Complexity score correlated with morbidity and difficulty outcomes. Conclusion The study shows that the Aristotle Basic Complexity score, the Risk Adjustment for Congenital Heart Surgery category, and the Society of Thoracic Surgeons and European Association for Cardiothoracic Surgery mortality category are tools of case mix stratification to analyze congenital heart surgery outcomes in a subset of the Indian population.
Advantages of upper brachial artery cannulation in aortic surgery
Authors: Yilmazkaya Bayram , Gurkahraman Sami , Yondem Omer Zuhtu , Hijazi Alaa , Algin Ibrahim H , Yesilay Aytekin 
Published: July 2013

Background The best method of cerebral protection during aortic arch surgery remains controversial. However, antegrade cerebral perfusion seems to be the most favorable because of better neurological outcomes. Although there have been many studies on antegrade cerebral perfusion via upper brachial cannulation, there is a lack of studies focusing particularly on local complications, with objective findings. The aim of this study was to investigate the local neurological and vascular complications following upper brachial cannulation. Methods and results This study included 44 patients who underwent procedures on the ascending aorta, aortic arch, or descending aorta with upper brachial artery cannulation for cardiopulmonary bypass at OSM Ortadogu Hospital and Cankaya Hospital between January 2009 and April 2012. The mean age of the 32 (72.7%) men and 12 (27.3%) women was 55.2 ± 12.3 years. Doppler analysis of the upper brachial artery was performed in 26 (59%) patients. Mean follow-up time for Doppler analysis was 5.7 ± 2 months. The mean antegrade cerebral perfusion time was 35 ± 16.1 min. The mean degree of hypothermia was 25.1 ℃ ± 2.0 ℃. Hospital death occurred in 4 (9.1%) patients, and 2 (4.5%) suffered local neurologic complications. Electromyelography analysis was carried out in the 2 patients who suffered local neurologic symptoms. Conclusions Brachial artery cannulation is technically simple and less time consuming, thus suitable even for emergency cases. With an acceptable risk of local complications, we recommend routine use of upper brachial cannulation for antegrade cerebral perfusion.
Expression and clinical significance of connective tissue growth factor in thyroid carcinomas
Authors: Wang Guimin , Zhang Wei , Meng Wei , Liu Jia , Wang Peisong , Lin Shan , Xu Liyan , Li Enmin , Chen Guang 
Published: July 2013

Objectives To examine expression of the connective tissue growth factor ( CTGF) gene in human thyroid cancer and establish whether a correlation exists between the presence of CTGF protein and clinicopathological parameters of the disease. Methods CTGF protein expression was investigated retrospectively by immunohistochemical analysis of CTGF protein levels in thyroid tumour tissue. Associations between immunohistochemical score and several clinicopathological parameters were examined. Results In total, 131 thyroid tissue specimens were included. High levels of CTGF protein were observed in papillary thyroid carcinoma tissue; benign thyroid tumour tissue scored negatively for CTGF protein. In papillary thyroid carcinoma, there was a significant relationship between high CTGF protein levels and Union for International Cancer Control disease stage III–IV, and presence of lymph node metastasis. In papillary thyroid carcinomas, CTGF protein levels were not significantly associated with sex or age. Conclusions These findings suggest that the CTGF protein level is increased in papillary thyroid carcinoma cells compared with benign thyroid tumours. CTGF expression might play a role in the development of malignant tumours in the thyroid.
Angiotensin-converting enzyme insertion/deletion gene polymorphism and risk of intracranial aneurysm in a Chinese population
Authors: Liu Yi , Li Peng , Hu Xiao , Hu Yu , Sun Hao-Gen , Ma Wei-Chao , Qiao Fei , He Min , You Chao 
Published: July 2013

Objective The relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphisms and intracranial aneurysm (IA) has been studied in Caucasian and Japanese populations. The present study aimed to investigate this association in a Chinese population. Methods Patients with confirmed IA and age- and sex-matched control subjects without evidence of IA were enrolled. ACE I/D gene polymorphisms were analysed using polymerase chain reaction–restriction fragment length polymorphism. Results A total of 220 patients with IA and 220 matched controls were enrolled. In the IA group, 64, 106 and 50 patients were of the II, ID and DD genotypes, respectively, compared with 44, 99 and 77 subjects in the control group. The ACE DD genotype and D allele frequencies were significantly lower in the IA group compared with the control group. There were no statistically significant differences in the site, shape, size and Fisher Grade of aneurysms between genotypes in patients with IA. Conclusion The ACE DD genotype may be a protective factor for IA in a Chinese population.