bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant chemotherapy may contribute to an increased risk for metabolic syndrome in patients with breast cancer
Authors: Bicakli Derya Hopanci , Varol Umut , Degirmenci Mustafa , Tunali Didem , Cakar Burcu , Durusoy Raika , Karaca Burcak , Ali Sanli Ulus , Uslu Ruchan 
Published: September 2014

Purpose Cytotoxic treatment may cause weight gain and important alterations in the metabolic status of breast cancer (BC) patients. The aim of this study was to investigate the changes in metabolic and anthropometric parameters of patients with BC who received adjuvant chemotherapy. Methods All consecutive women treated with adjuvant TAC (docetaxel 75 mg/m2, doxorubicine 50 mg/m2, cyclophosphamide 500 mg/m2) chemotherapy for node-positive breast carcinoma at our Institution between 2008 and 2010 were included. Results Among 104 patients, 84 of them were stage II and 20 of them were stage III. When we compared the measurements between 1st and 6th adjuvant chemotherapy, we observed statistically significant increases in weight and serum triglyceride levels, and decreases in high density lipoprotein, apolipoprotein A-1, transferrin, albumin and prealbumin levels. An elevation of follicle stimulating hormone, luteinizing hormone together with the decrease of estradiol was detected. Waist-to-hip ratio has also increased significantly. In subgroup analyses, we observed dramatic changes in body mass index in pre-menopausal women whereas no significant change was seen in the post-menopausal group. Conclusions Adjuvant chemotherapy may contribute to an increased risk for metabolic syndrome in patients with BC and these changes are more profound in pre-menopausal patients.
Differential and limited expression of mutant alleles in multiple myeloma
Authors: Rashid Naim U. , Sperling Adam S. , Bolli Niccolo , Wedge David C. , Van Loo Peter , Tai Yu-Tzu , Shammas Masood A. , Fulciniti Mariateresa , Samur Mehmet K. , Richardson Paul G. , Magrangeas Florence , Minvielle Stephane , Futreal P. Andrew , Anderson Kenneth C. , Avet-Loiseau Herve , Campbell Peter J. , Parmigiani Giovanni , Munshi Nikhil C. 
Published: September 2014

Key Points
The majority of mutations are found in genes that have low or no detectable biological expression. Mutated genes often show differential allelic expression in multiple myeloma patient samples.
Predicting virus mutations through statistical relational learning
Authors: Cilia Elisa , Teso Stefano , Ammendola Sergio , Lenaerts Tom , Passerini Andrea 
Published: September 2014

Abstract

Background
Viruses are typically characterized by high mutation rates, which allow them to quickly develop drug-resistant mutations. Mining relevant rules from mutation data can be extremely useful to understand the virus adaptation mechanism and to design drugs that effectively counter potentially resistant mutants.

Results
We propose a simple statistical relational learning approach for mutant prediction where the input consists of mutation data with drug-resistance information, either as sets of mutations conferring resistance to a certain drug, or as sets of mutants with information on their susceptibility to the drug. The algorithm learns a set of relational rules characterizing drug-resistance and uses them to generate a set of potentially resistant mutants. Learning a weighted combination of rules allows to attach generated mutants with a resistance score as predicted by the statistical relational model and select only the highest scoring ones.

Conclusions
Promising results were obtained in generating resistant mutations for both nucleoside and non-nucleoside HIV reverse transcriptase inhibitors. The approach can be generalized quite easily to learning mutants characterized by more complex rules correlating multiple mutations.
Self-assembly behaviors of thermal- and pH- sensitive magnetic nanocarriers for stimuli-triggered release
Authors: Kuo Chih-Yu , Liu Ting-Yu , Hardiansyah Andri , Lee Chia-Fen , Wang Man-Sheng , Chiu Wen-Yen 
Published: September 2014

Abstract
In the present work, we prepare thermo- and pH-sensitive polymer-based nanoparticles incorporating with magnetic iron oxide as the remote-controlled, stimuli-response nanocarriers. Well-defined, dual functional tri-block copolymer poly[(acrylic acid)-block-(N-isopropylacrylamide)-block-(acrylic acid)], was synthesized via reversible addition-fragmentation chain-transfer (RAFT) polymerization with S,S′-bis(α,α′-dimethyl-α″-acetic acid)trithiocarbonate (CMP) as a chain transfer agent (CTA). With the aid of using 3-aminopropyltriethoxysilane, the surface-modified iron oxides, Fe3O4-NH2, was then attached on the surface of self-assembled tri-block copolymer micelles via 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride/N-hydroxysuccinamide (EDC/NHS) crosslinking method in order to furnish not only the magnetic resources for remote control but also the structure maintenance for spherical morphology of our nanocarriers. The nanocarrier was characterized by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), and ultraviolet–visible (UV/Vis) spectral analysis. Rhodamine 6G (R6G), as the modeling drugs, was encapsulated into the magnetic nanocarriers by a simple swelling method for fluorescence-labeling and controlled release monitoring. Biocompatibility of the nanocarriers was studied via 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, which revealed that neither the pristine nanocarrier nor the R6G-loaded nanocarriers were cytotoxic to the normal fibroblast cells (L-929 cells). The in vitro stimuli-triggered release measurement showed that the intelligent nanocarriers were highly sensitive to the change of pH value and temperature rising by the high-frequency magnetic field (HFMF) treatment, which provided the significant potential to apply this technology to biomedical therapy by stimuli-responsive controlled release.
Cytotoxic compounds from Laurencia pacifica
Authors: Zaleta-Pinet Diana A , Holland Ian P , Muñoz-Ochoa Mauricio , Murillo-Alvarez J Ivan , Sakoff Jennette A , van Altena Ian A , McCluskey Adam 
Published: September 2014

Abstract

Background
The current investigation sought to explore the nature of the secondary metabolites in the algae, Laurencia pacifica.

Results
This report details the first isolation of the sesquiterpenes isoaplysin (1), isolaurenisol (2), debromoisolaurinterol (3), debromoaplysinol (4), laur-11-en-10-ol (5), 10α-hydroxyldebromoepiaplysin (6), and the previously unknown 10-bromo-3,7,11,11-tetramethylspiro[5.5]undeca-1,7-dien-3-ol (7) from the algae, Laurencia pacifica. Isoaplysin (1) and debromoaplysinol (4) showed promising levels of growth inhibition against a panel cancer-derived cell lines of colon (HT29), glioblastoma (U87, SJ-G2), breast (MCF-7), ovarian (A2780), lung (H460), skin (A431), prostate (Du145), neuroblastoma (BE2-C), pancreas (MIA), murine glioblastoma (SMA) origin with average GI50 values of 23 and 14 μM.

Conclusions
Isoaplysin (1) and debromoaplysinol (4) were up to fourfold more potent in cancer-derived cell populations than in non-tumor-derived normal cells (MCF10A). These analogues are promising candidates for anticancer drug development.
miR-142–3p Down-Regulation Contributes to Thyroid Follicular Tumorigenesis by Targeting ASH1L and MLL1
Authors: Colamaio Marianna , Puca Francesca , Ragozzino Elvira , Gemei Marica , Decaussin-Petrucci Myriam , Aiello Concetta , Bastos André Uchimura , Federico Antonella , Chiappetta Gennaro , Del Vecchio Luigi , Torregrossa Liborio , Battista Sabrina , Fusco Alfredo 
Published: September 2014

Abstract

Context:
A previous micro-RNA expression profile of thyroid follicular adenomas identified miR-142 precursor among the miRNAs downregulated in the neoplastic tissues compared to normal thyroid gland.

Objective:
The aim of this work has been to assess the expression of miR-142–3p in a large panel of follicular thyroid adenomas and carcinomas and evaluate its effect on thyroid cell proliferation and target expression.

Design:
The expression of miR-142–3p was analyzed by qRT-PCR in thyroid follicular adenomas and carcinomas, compared to normal thyroids. MiR-142–3p expression was restored in WRO cells and the effects on cell proliferation and target expression were evaluated.

Results:
Here we show that miR-142–3p is downregulated in FTAs, FTCs, and FVPTCs. MiR-142–3p was demonstrated to reduce the proliferation rate of WRO and FTC133 cells, supporting its tumor suppressor role in thyroid cancerogenesis. Moreover, this microRNA was able to downregulate the expression of ASH1L and MLL1, by direct and indirect mechanisms, respectively. Consistently, an inverse correlation between miR-142–3p expression and ASH1L and MLL1 proteins was found in thyroid follicular adenomas and carcinomas. ASH1L and MLL1, which belong to the Trithorax group (TrxG) proteins and are major regulators of Homeobox gene expression, maintain active target gene transcription by histone 3 lysine 4 methylation. Interestingly, we found that FTCs and FTC cell lines express tumor specific, shorter forms of the two proteins. The capability of miR-142–3p to modulate the levels of these tumor-associated forms and to reactivate thyroid-specific Hox gene expression, likely contributes to its tumor suppressive function.

Conclusions:
These data demonstrate that miR-142–3p downregulation has a role in thyroid tumorigenesis, by regulating ASH1L and MLL1.
Sulfonylurea Treatment Before Genetic Testing in Neonatal Diabetes: Pros and Cons
Authors: Carmody David , Bell Charles D. , Hwang Jessica L. , Dickens Jazzmyne T. , Sima Daniela I. , Felipe Dania L. , Zimmer Carrie A. , Davis Ajuah O. , Kotlyarevska Kateryna , Naylor Rochelle N. , Philipson Louis H. , Greeley Siri Atma W. 
Published: September 2014

Context:
Diabetes in neonates nearly always has a monogenic etiology. Earlier sulfonylurea therapy can improve glycemic control and potential neurodevelopmental outcomes in children with KCNJ11 or ABCC8 mutations, the most common gene causes.

Objective:
Assess the risks and benefits of initiating sulfonylurea therapy before genetic testing results become available.

Design, Setting, and Patients:
Observational retrospective study of subjects with neonatal diabetes within the University of Chicago Monogenic Diabetes Registry.

Main Outcome Measures:
Response to sulfonylurea (determined by whether insulin could be discontinued) and treatment side effects in those treated empirically.

Results:
A total of 154 subjects were diagnosed with diabetes before 6 months of age. A genetic diagnosis had been determined in 118 (77%), with 73 (47%) having a mutation in KCNJ11 or ABCC8. The median time from clinical diagnosis to genetic diagnosis was 10.4 weeks (range, 1.6 to 58.2 wk). In nine probands, an empiric sulfonylurea trial was initiated within 28 days of diabetes diagnosis. A genetic cause was subsequently found in eight cases, and insulin was discontinued within 14 days of sulfonylurea initiation in all of these cases.

Conclusions:
Sulfonylurea therapy appears to be safe and often successful in neonatal diabetes patients before genetic testing results are available; however, larger numbers of cases must be studied. Given the potential beneficial effect on neurodevelopmental outcome, glycemic control, and the current barriers to expeditious acquisition of genetic testing, an empiric inpatient trial of sulfonylurea can be considered. However, obtaining a genetic diagnosis remains imperative to inform long-term management and prognosis.
Catalytic Organic Reactions on the Surface of Silver(I) Oxide in Water
Authors: Ueno Masaharu , Tanoue Arata , Kobayashi Shū 
Published: September 2014

Abstract
We have developed Ag2O-catalyzed allylation reactions of aldehydes with allylsilanes in water, providing homoallylic alcohols in high yields with high anti-selectivities. It was found that the reactions proceeded not in the water solution but on the surface of Ag2O. We could reduce the amount of the catalyst to less than 0.01 mol %. Moreover, an asymmetric allylation reaction was performed in water with high yield and moderate enantioselectivity by using a chiral phosphine ligand.
Deletion of ENTPD3 does not impair nucleotide hydrolysis in primary somatosensory neurons or spinal cord
Authors: McCoy Eric , Street Sarah , Taylor-Blake Bonnie , Yi Jason , Edwards Martin , Wightman Mark , Zylka Mark 
Published: September 2014

Ectonucleotidases are membrane-bound or secreted proteins that hydrolyze extracellular nucleotides. Recently, we identified three ectonucleotidases that hydrolyze extracellular adenosine 5’-monophosphate (AMP) to adenosine in primary somatosensory neurons. Currently, it is unclear which ectonucleotidases hydrolyze ATP and ADP in these neurons. Ectonucleoside triphosphate diphosphohydrolases (ENTPDs) comprise a class of enzymes that dephosphorylate extracellular ATP and ADP. Here, we found that ENTPD3 (also known as NTPDase3 or CD39L3) was located in nociceptive and non-nociceptive neurons of the dorsal root ganglion (DRG), in the dorsal horn of the spinal cord, and in free nerve endings in the skin. To determine if ENTPD3 contributes directly to ATP and ADP hydrolysis in these tissues, we generated and characterized an Entpd3 knockout mouse. This mouse lacks ENTPD3 protein in all tissues examined, including the DRG, spinal cord, skin, and bladder. However, DRG and spinal cord tissues from Entpd3-/- mice showed no reduction in histochemical staining when ATP, ADP, AMP, or UTP were used as substrates. Additionally, using fast-scan cyclic voltammetry (FSCV), adenosine production was not impaired in the dorsal spinal cord of Entpd3-/- mice when the substrate ADP was applied. Further, Entpd3-/- mice did not differ in nociceptive behaviors when compared to wild-type mice, although Entpd3-/- mice showed a modest reduction in β-alanine-mediated itch. Taken together, our data indicate that deletion of Entpd3 does not impair ATP or ADP hydrolysis in primary somatosensory neurons or in dorsal spinal cord. Moreover, our data suggest there could be multiple ectonucleotidases that act redundantly to hydrolyze nucleotides in these regions of the nervous system.
Do the Flags Related to Immature Granulocytes Reported by the Sysmex XE-5000 Warrant a Microscopic Slide Review?
Authors: Eilertsen Heidi , Hagve Tor-Arne 
Published: September 2014

AbstractObjectives:The Sysmex XE-5000 instruments (Sysmex, Kobe, Japan) count immature granulocytes (IGs) and use the “Imm Gran?” flag to signal unreliable results. This study investigated the usefulness of the “Imm Gran?” flag and the analytical and diagnostic performance of the IG measurements in a side-by-side evaluation.Methods:In total, 408 samples were analyzed on three XE-5000 instruments. The IG count and the “Imm Gran?” flag reports from all three instruments were used for reproducibility studies. The diagnostic performance of the automated IGs and the “Imm Gran?” flag were studied by comparing the XE-5000 results with the results of the manual differential.Results:The reproducibility of the “Imm Gran?” flagging between instruments was poor (қ, 0.75–0.80). The most significant contributor to the report of the “Imm Gran?” flag was bands, and the flag played a minor role in detecting blasts. The interinstrument reproducibility of the IG counts was high (intraclass correlation, 0.99). The IG count reported by XE-5000s was higher than the manual IG count (36%–55%), and the difference and the variability tended to increase with increasing levels of IGs.Conclusions:The “Imm Gran?” flag has a poor analytical quality and gives no substantial information on the presence of blasts in the sample. We therefore suggest reporting the automated IG count without initial microscopic slide review.
Seeing What Others Miss: A Study of Women Entrepreneurs in High-Growth Startups
Authors: Neill Stern , Metcalf Lynn , York Jonathan L. 
Published: September 2014

AbstractA pressing question in entrepreneurial research is where opportunities come from. Prior research indicates that some opportunities stem from known parameters and outcomes; some are discovered through engagement with unknown but knowable factors; and others are unknowable until brought into being through a creative process. This paper explores the second and more prevailing view in entrepreneurial research – that individuals discover business opportunity – and examines how high-growth entrepreneurs perceive opportunity through engagement with the world. Survey results, based on responses from 165 women entrepreneurs in high-growth startups, indicate that individuals with a strong discover mindset act and think in ways that support opportunity perception. Coupled with a belief in her abilities, the entrepreneur is more likely to move from opportunity perception to new venture creation. Results from semi-structured interviews with women from the same population elucidate the survey findings and yield implications for entrepreneurial theory and practice.
Production of functionally graded SiC/Al-Cu-Mg composite by centrifugal casting
Authors: Savaş Ömer , Kayıkcı Ramazan , Fiçici Ferit , Çolak Murat , Deniz Gürhan , Varol Faruk 
Published: September 2014

AbstractThis study is aimed at investigating the production and wear properties of a functionally graded (FG) silicon carbide (SiC)-reinforced composite material, which was produced by stir casting followed by centrifugal casting. SiC powder (5 wt.%) was added into liquid aluminum at 750°C via stir casting, at which temperature a centrifugal force was applied to the mixture to drive the SiC particles toward the outer region of the mold. The results showed that two distinct regions formed in the cast samples after the centrifugation process. The outer region showed approximately 25% SiC particles resulting in almost SiC particle-free area in the internal region of the FG SiC-reinforced composite material. The test results showed that higher hardness and higher wear resistance could be obtained at the SiC-rich periphery of the cast FG composite material.
The changing dynamics of US inflation persistence: a quantile regression approach
Authors: Wolters Maik H. , Tillmann Peter 
Published: September 2014

AbstractWe examine both the degree and the structural stability of inflation persistence at different quantiles of the conditional inflation distribution. Previous research focused exclusively on persistence at the conditional mean of the inflation rate. As economic theory provides reasons for inflation persistence to differ across conditional quantiles, this is a potentially severe constraint. Conventional studies of inflation persistence cannot identify changes in persistence at selected quantiles that leave persistence at the mean of the distribution unchanged. Based on post-war US data we indeed find robust evidence for a structural break in persistence at all quantiles of the inflation process in the early 1980s. While prior to the 1980s inflation was not mean reverting, quantile autoregression based unit root tests suggest that since the end of the Volcker disinflation the unit root can be rejected at every quantile of the conditional inflation distribution.
Land Transportation Contractor Management: A Case Study from Egypt
Authors: Soliman Yasser , Diaa Mohamed 
Published: September 2014

Abstract
Land transportation represents one of the highest concerns regarding employee safety in the oil and gas industry. This routine activity has led to many road traffic incidents, frequently caused by third-party drivers. An oilfield services company has introduced processes and tools aimed at reducing risk in all aspects of its land journeys. This paper focuses on the management of land transportation contractors (LTCs) and presents results from the company's operations in Egypt. LTC management is mandatory in order to achieve full compliance with the oilfield service company's HSE directives. This paper examines the four key elements of the company's LTC management: contractor driver training and qualification, contractor vehicle specifications and inspection, demand planning, and contractor performance monitoring.
Contractor driver training and qualification includes pre-hire driver interview and screening, driver training courses, and engaging contractor drivers in HSE campaigns. Penalties are applied for non-compliance and good practice is rewarded. Contractor vehicle specifications and inspection includes vehicle inspection training and tools for the LTC to self-check that its vehicles conform to defined standards. Demand planning minimizes the use of call-out contractors by challenging the necessity of trips and considering alternative dedicated resources. If no alternative is identified, preference is given to a pool of trained call-out drivers, and portable in-vehicle monitoring systems (IVMSs) are used to identify non-compliance. Contractor performance monitoring is achieved through monitoring the history of reported incidents, contractor audits, key performance indicators (KPIs), service quality meetings, applying remedial work plans, and LTC participation in safety meetings.
This paper discusses how the oilfield services company has applied its LTC management processes since starting work with a land transport contractor in Egypt in 2008. In 2012, the company utilized more than 250 of the LTCs vehicles, both leased and on call-out. During a four year period, the LTCs automotive accident rate per mile of catastrophic, major, and serious (CMS) incidents in Egypt has decreased by 100%.
Pre-emptive Integrated Well Control Risk Management
Authors: Cuthbert Andy , Waters John 
Published: September 2014

AbstractAlthough industry regulatory risk management practices relating to well control are generally adhered to, unrealistically optimistic assumptions about the ability to control and contain a catastrophic event are still held by some. This is not necessarily a fault of the risk processes per se, but exposes an industry deficiency when expectations of any given risk assessment lead to a false sense of security, especially when history has shown that when stress-tested some contingency plans have failed to deliver.Historically, in the aftermath of a disaster, lobbying for tighter legislation and regulation has been the reaction; more enlightened operators, in reviewing their overall health safety and environment (HSE) culture realize and understand the need to incorporate a well-constructed Emergency Response Plan (ERP) including a Well Control Contingency Plan (WCCP) in to the pre-execution phase of their well planning and to keep these plans updated throughout the execution of the well.As insurance premiums to underwrite an endeavour become increasingly cost prohibitive the approach towards prevention rather than cure becomes paramount, and more emphasis and energy is placed on constructing a robust and comprehensive risk assessment as part of the overall risk management of a well, regulatory requirements notwithstanding.To this end operators would benefit from leveraging from both within and without the operator's organization the years of practical expertise at hand, to assist in assembling a comprehensive and vigorous risk prevention and mitigation approach. This might include auditing an existing plan or building one from scratch using a qualified body that specializes in the complexities that constitute an emergency response, mitigating insurance underwriting costs and ensuring that contingency planning is established at the earliest opportunity.