bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standardization of Phomopsis sp. extract and prediction of anti breast cancer activity from the main compound through molecular docking
Authors: Husnawati H , Kusmardi K , Andrianto D , Julistiono H , Mulyadi M , Setianingrum N , Artika I M , Hasan A E Z 
Published: July 2024

Abstract
Endophytic fungi isolated from Indonesian soursop (Annona muricata) leaves, which have the potential to treat breast cancer, have been successfully isolated since 2016. Identification based on the Internal Transcribed Spacer (ITS) gene revealed that fungi close to Phomopsis sp. The fungi were stored, subcultured, and extracted with ethyl acetate for in vitro and in vivo studies. To be registered as a medicinal ingredient and meet the requirements of the Indonesian Food and Drug Supervisory Agency (BPOM, Badan Pengawas Obat dan Makanan), it is necessary to ensure the standardization, safety, and quality of the Phomopsis extract. The results showed that the Phomopsis extract met the BPOM requirements for organoleptic, water, and solvent content, microbial and heavy metal contamination, total aflatoxin, and metabolite content. Analysis of the Phomopsis extract content also showed that the compounds in the two production batches were stable, with the highest relative abundance of 7-hydroxycoumarin. In silico studies with molecular docking show that the affinity energy of 7-hydroxycoumarin docking with the estrogen receptor alpha (ERα) and thymidine kinase 1 (TK1) has a lower negativity value than the comparison ligand (-6.7 and -6.8 kcal/mol).
On quantum states for angular position and angular momentum of light
Authors: Skagerstam Bo-Sture K , Rekdal Per K 
Published: July 2024

Abstract
In the present paper we construct a properly defined quantum state

ψ
(
θ
)

expressed in terms of elliptic Jacobi theta functions for the self-adjoint observables angular position θ and the corresponding angular momentum operator

L
=
−
i

d

/

d

θ

in units of

ℏ
=
1

. The quantum uncertainties Δθ and ΔL for the state are well-defined and are shown to give a lower value of the uncertainty product

Δ
θ
Δ
L

in contrast to the so called minimal uncertainty states as discussed in Franke-Arnold et al (2004 New J. Phys.
6 103-1-8). The mean value

⟨
L
⟩

of the state

ψ
(
θ
)

is not required to be an integer. In the case of any half-integer mean value

⟨
L
⟩

the state constructed exhibits a remarkable critical behavior with upper and lower bounds

Δ
θ
=

π
2

/

3
−
2

and

Δ
L
=
1

/

2

.
Configurable lateral optical forces from twisted mixed-dimensional MoO3 homostructures
Authors: Yan Qizhi , Chen Runkun , Li Peining , Zhang Xinliang 
Published: July 2024

Abstract
In recent years, the concept of hyperbolic phonon polaritons (HPPs) has revolutionized the field of nanophotonic, enabling unprecedented control over light-matter interactions at the nanoscale. Here, we theoretically propose and study the lateral optical forces in twisted mixed-dimensional MoO3 homostructures. Assisted with the low-symmetry HPPs, we realize a lateral optical force exerted on the Au nanoparticles near the surface of mixed-dimensional MoO3 homostructures with a linear polarized incident light. By controlling the polarization state, incident angle of light and the twisted angle of MoO3, the amplitude and direction of the lateral optical forces can be tailored in the mid-infrared range. Our findings provide a new platform for engineering lateral optical forces to manipulate diverse objects in a flexible and efficient manner.
Hope and the Virtue of Creative Resolve
Authors: Hassoun Nicole 
Published: July 2024

Abstract
Vast swaths of humanity live in desperate poverty. Many suffer from oppression, terrible violence, and disease. Moreover, everyone remains incredibly vulnerable to natural and anthropogenic threats like climate change and pandemics. So, some may deny we should try to help people live minimally well because doing so seems hopeless. Others may worry that, in trying to help others, we will risk our own ability to live well enough. How we should respond to such apparent tragedy? This chapter argues that by cultivating a new virtue that I call creative resolve we can help many people live at least minimally good lives. This virtue requires us to try hard to come up with new ways of helping people live good (enough) lives. Although creative resolve does not appear on canonical lists of the virtues, it can help us overcome apparent tragedy and ensure that people everywhere flourish.
Jack Lindsay, Socialist Humanism, and the Communist Historical Novel
Authors: Connor John T 
Published: July 2024

Abstract
This chapter introduces Jack Lindsay as the major theorist and practitioner of the ‘revolutionary historical novel’ in Britain and another case study of the national turn. One of Britain’s most visible communist writers during the cultural Cold War, Lindsay first made his name through a cluster of initiatives in 1920s Sydney and London to propagate the art and opinions of his father, the Australian artist Norman Lindsay. This version of Australian modernism held national culture and identity in contempt, but as a Popular Front convert to communism and later champion of socialist realism, Lindsay had to revise his position. He became a leading proponent of ‘revolutionary nationhood’, privileging British traditions of democratic struggle and advancing a national-popular aesthetic. But his vision of the socialist horizon as a world without alienation kept faith with his earliest Australian investments, and these informed his contribution to the debates that in the late 1950s launched the British New Left.
Jacobean to Early Stuart
Authors: Verweij Sebastiaan 
Published: July 2024

Abstract
This chapter reviews the potential for impact of a Scottish poetics on early-Stuart English literary culture around the succession of James VI/I (1603). It identifies four sites of convergence: first, a Jacobean poetics shaped by the pre-1603 court cultures of James VI; second, a Scottish Protestant poetry; third, the emergence of newly fashioned identities for poets and writers (the ‘Scoto-Britains’); and fourth, the interchange of books and manuscripts across the border, which also saw some Scottish poets in English printed collections, and the appearance of English and Scottish poetry alongside each other in manuscript verse anthologies. Much traditional criticism of seventeenth-century English poetry ignores what cultural imports the newly crowned king may have brought with him, and so this chapter argues that there was in fact a dynamic relationship between aspects of Scottish and English poetry and poetics.
Poetry, Publishers, and Print
Authors: Depledge Emma 
Published: July 2024

Abstract
This chapter focuses on the three most prominent publishers in seventeenth-century London—Humphrey Moseley, Henry Herringman, and Jacob Tonson—to demonstrate how stationers helped to craft the canon of English poetry through what they published, the material forms in which it circulated, and also through what they chose not to publish. As illustrated through analysis of print editions of John Milton, John Dryden, and Katherine Philips, a book’s format, mis-en-page, typeface, paratexts, price, contents, paper, and the arrangement of poetic texts within it all shape meaning, access, and collection habits in important ways. Further, the chapter argues that texts and authors were not simply selected for publication on the basis of perceived commercial demand but also to correspond to the professional strategies and ambitions of individual publishers. Thus, in helping to canonise specific authors and poems, publishers often sought not simply to make money but also to shape their own reputation and legacy.
Poetic Miscellanies in Manuscript and Print
Authors: O’Callaghan Michelle 
Published: July 2024

Abstract
The term ‘miscellany’ slowly and unevenly came into usage across the seventeenth and eighteenth centuries in its modern sense to refer to a book compiled of literary compositions of various kinds and by multiple authors. Looking across early modern miscellanies, it is noticeable that there was no fixed formula or structure in either manuscript or print. Instead, miscellanies are distinguished by an instructive diversity of practice, whether in relation to organising principles, attribution of authorship, or skill. Manuscript verse miscellanies flourished alongside printed collections in the seventeenth century and were produced at universities, the Inns of Court, and in households, both elite and non-elite. Although the history of miscellany production is not evolutionary, progressing incrementally towards stability as a class of books, looking across the seventeenth century, it is possible to see shifts in how miscellanies are framed, the types of poetry they collect, practices of attribution, and how readerships are imagined.
Rhetoric and Figurative Language: Metaphor
Authors: Read Sophie 
Published: July 2024

Abstract
This chapter concerns the development of attitudes towards rhetoric in the seventeenth century, following its mixed fortunes in the face of ideological challenges from the political upheavals of the civil war and the new science. It sets out the educational and literary background, before turning to metaphor as a central rhetorical trope: there are detailed close readings showing how the figure of metaphor works logistically, and outlining some of the difficulties and anxieties surrounding its operation. The chapter then suggests some reasons for why figurative language and rhetoric more generally might have fallen out of favour in the later seventeenth century; it concludes by suggesting that, although formal rhetorical learning was in decline in this period, figurative language adapted and lived on in post-Restoration poetry.
Allusion
Authors: Green Mandy 
Published: July 2024

Abstract
Seventeenth-century poetry was steeped in allusion to the Bible, the Roman Augustan poets, especially Horace, Virgil, and Ovid, and increasingly to other poets writing in English and other European vernaculars. Such allusiveness proved a rich resource for poets whose readers belonged to a shared poetic tradition; their work could be extended and enriched by a strategy of deliberate allusion, enjoining the reader to uncover the significance of what lies beneath the surface meaning. At the centre of Milton’s Garden of Eden is Eve, glimpsed as both like and unlike Ovid’s Proserpine, but the defining quality of this pastoral paradise is the first couple’s love for one another. On a smaller scale, Marvell distils a different vision of paradisal delight in his solitary pastoral retreat, ‘The Garden’. In the seventeenth century, allusion created vibrant effects in the art of a miniaturist, as in an expansive canvas such as Milton’s epic poem, Paradise Lost.
Sonnet
Authors: Netzley Ryan 
Published: July 2024

Abstract
The sonnet in the seventeenth century becomes a disarticulated, stand-alone entity, in contradistinction to the sonnet sequences that dominate the 1590s. One result of that change is an enhanced obsession with the relationship between a poem and the social world it inhabits. In becoming an individual poem, as opposed to one in a series, the sonnet ceases to be an exercise in serial contemplation and becomes instead a distinct moment or act of deliberation. This chapter examines sonnets by eight authors and explores how this poetic form contributes to the notion of a literature that acts and has real effects in the social world—as opposed to a vision of self-contained, escapist aesthetics. These poems pose important challenges to literature’s pedagogical utility, and an understanding of poetics inherited from Sidney and Horace, as well as more modern accounts of poetry’s performative action.
Epigram
Authors: Coiro Ann Baynes 
Published: July 2024

Abstract
The epigram, an ancient form, is both fundamental to humanist education and shapes new ways of thinking in the seventeenth century. The epigram’s classical models, Martial and the Greek Anthology, arrange epigrams into networks. Martial arranges his epigrams in groups of about a hundred, conveying a self that interacts with and observes contemporary society. The Greek Anthology gathers thousands of strikingly heterogeneous epigrams, and this more expansive model of gathering rivals Martial’s or subsumes it during the seventeenth century. Emblems develop inscriptions into image, motto, and epigram. Visual and concrete, seventeenth-century epigrams abet new scientific thinking. Assembled in networks, they allow new political and philosophical speculation. Concise, witty, and often tightly rhymed, they shape English writing from the sonnet through the prose essay, from metaphysical poetry through the heroic couplet’s dominance. The seventeenth-century epigram is exemplified by eight paired poets: Donne and Jonson; Herbert and Crashaw; Herrick and Cavendish; Marvell and Milton.
Georgic
Authors: Lobis Seth 
Published: July 2024

Abstract
With roots in Hesiod’s Works and Days, Virgil’s Georgics, and the Bible, seventeenth-century English georgic was a diverse, flexible genre. Recognition of the diversity and flexibility of early modern English georgic has served to correct a long-standing literary-historical tendency to regard the genre as if it were buried in barren ground until its eighteenth-century efflorescence. A less rigidly imitative view of seventeenth-century georgic, one neither narrowly fixed on the Virgilian model nor disconnected from it, reveals a richly varied landscape of works markedly different in scope and style: vast and copious, like Michael Drayton’s Poly-Olbion; classically restrained, like Jonson’s estate poems; loco-reflective, like Denham’s Cooper’s Hill; exploratory and extravagant, like Marvell’s ‘Upon Appleton House’; stately and historical, like Dryden’s Annus Mirabilis; and universal and intimate, like Milton’s Paradise Lost.
Ode
Authors: Yoshinaka Takashi 
Published: July 2024

Abstract
The development of lofty, often celebratory odes in seventeenth-century England draws on two main classical models, Pindar and Horace. After giving a concise definition of the ode, which has musical and athletic origins, and describing related variations of it, this chapter traces the seventeenth century’s investment in this characteristically ambivalent form in light of the desire for psychological stability, the pressures of propaganda, and the rise of scepticism and heterodoxy. Framing the movement of the ode through the century with the idea of doubleness, the chapter also offers individual close readings of Ben Jonson’s Cary-Morison Ode, Andrew Marvell’s ‘Horatian Ode’, Abraham Cowley’s ‘Brutus’ ode, and John Dryden’s song for St Cecilia’s Day: ‘Alexander’s Feast’, which moves from the doubled mode of odes in public contexts towards the type of Romantic odes in which the poet’s private experience and emotion become central.
Cavalier Poetry
Authors: McDowell Nicholas 
Published: July 2024

Abstract
‘The Cavalier poets’ remains the short-hand phrase for those mid-seventeenth-century poets seen as central to the Caroline lyric tradition, in particular, Robert Herrick, Thomas Carew, Sir John Suckling, and Richard Lovelace. ‘Cavalier’ identifies a school of writing largely by allegiance to the royalist cause in the English Civil Wars rather than by a distinguishing literary attribute. Yet none of these four writers ever fought in the Civil Wars, and, apart from Lovelace, they wrote their poetry mostly before the wars even began. This chapter shifts the critical focus towards the recovery of the distinctive literary features of a poetic tradition shaped by a vibrant and learned engagement with European literary culture. While Carew, Suckling, Lovelace, and Herrick remain the central figures in this reconfiguring of the ‘Cavalier mode’, they are regarded from the alternative perspective of a cosmopolitan culture of poetic experimentation encouraged by continental travel and involvement in inventive literary communities, both before and after the outbreak of civil war.
Andrew Marvell
Authors: Loxley James 
Published: July 2024

Abstract
Andrew Marvell is one of the most intriguing poets of the seventeenth century, with his distinctive mix of lyric interiority, acute political sensitivity, and unrestrained satire. This chapter starts from the point of view of one of Marvell’s contemporary readers encountering his poems in print for the first time; it then goes on to explore the varying dimensions of this body of work in lyric, political verse, and satire with an eye both for Marvell’s distinctive contribution to each genre and an eye for the poetic dynamics that operate across it, weaving through its different genres and preoccupations, and challenging its readers in the present as well as the past.
Katherine Philips
Authors: Prescott Sarah 
Published: July 2024

Abstract
The seventeenth-century poet Katherine Philips has predominantly been interpreted as an English poet of royalist sympathies preoccupied with the theme of female friendship in a Platonic coterie context that was reliant on manuscript circulation. This chapter explores these approaches but argues that the poet’s complex biographical and ideological background both expands these accepted interpretations and complicates them in a variety of ways. By looking instead at Philips primarily as an Anglophone Welsh women writer, who also spent a key part of her literary career in Dublin, it is suggested that she shaped her poetic identity within a local bardic as well as an archipelagic context. As such, Philips’ much noted cultivation of poetic friendship and her authorial practices can be seen as directly linked to and thus shaped by the cultural and geographical immediacy of her Welsh and Irish experience.
John Dryden
Authors: Lewis Jayne 
Published: July 2024

Abstract
This chapter addresses John Dryden’s exceptionally wide-ranging poetic oeuvre—encompassing elegy, satire, narrative verse, panegyric, prologue and epilogue, song, fable, ode, historical epic, religious meditation, and translation—under the rubric of poetics in transition. Dryden’s poetry is often seen spatially and positionally, in terms of its ideological stances, and thus in light of tensions and contradictions that these expose. But equally significant are the modes of movement—from line to line, from idea to idea, from genre to genre, from figure to figure, from faith to faith, and even from time to time—that not only negotiated personal passages between seasons of life but shaped anglophone literary culture in rapidly changing times. Attention to Dryden’s (ironically) lifelong preoccupation with death as a locus of transformation and an agent of change shows how his work over the last four decades of the seventeenth century turned English poetry into an activity of collective mourning, cultural reconstitution, and projected futurity.
Bee monitoring by community scientists: comparing a collections-based program with iNaturalist
Authors: Turley Nash E , Kania Sarah E , Petitta Isabella R , Otruba Elizabeth A , Biddinger David J , Butzler Thomas M , Sesler Valerie V , López-Uribe Margarita M 
Published: July 2024

Abstract
Bee monitoring, or widespread efforts to document bee community biodiversity, can involve data collection using lethal (specimen collections) or non-lethal methods (observations, photographs). Additionally, data can be collected by professional scientists or by volunteer participants from the general public. Collection-based methods presumably produce more reliable data with fewer biases against certain taxa, while photography-based approaches, such as data collected from public natural history platforms like iNaturalist, can involve more people and cover a broader geographic area. Few efforts have been made to quantify the pros and cons of these different approaches. We established a community science monitoring program to assess bee biodiversity across the state of Pennsylvania (USA) using specimen collections with nets, blue vane traps, and bowl traps. We recruited 26 participants, mostly Master Gardeners, from across the state to sample bees after receiving extensive training on bee monitoring topics and methods. The specimens they collected were identified to species, stored in museum collections, and the data added to public databases. Then, we compared the results from our collections to research-grade observations from iNaturalist during the same time period (2021 and 2022). At state and county levels, we found collections data documented over twice as much biodiversity and novel baseline natural history data (state and county records) than data from iNaturalist. iNaturalist data showed strong biases toward large-bodied and non-native species. This study demonstrates the value of highly trained community scientists for collections-based research that aims to document patterns of bee biodiversity over space and time.
Implementation and early outcomes with Pathogen Reduced Cryoprecipitated Fibrinogen Complex
Authors: Sethapati V Rakesh , Pham Tho D , Quach Thinh , Nguyen Anhthu , Le Jimmy , Cai Wei , Virk Mrigender Singh 
Published: July 2024

Abstract

Objectives
Cryoprecipitated antihemophilic factor (cryo) has been used for fibrinogen replacement in actively bleeding patients, dysfibrinogenemia, and hypofibrinogenemia. Cryo has a shelf life of 4 to 6 hours after thawing and a long turnaround time in issuing the product, posing a major limitation of its use. Recently, the US Food and Drug Administration approved Pathogen Reduced Cryoprecipitated Fibrinogen Complex (INTERCEPT Fibrinogen Complex [IFC]) for the treatment of bleeding associated with fibrinogen deficiency, which can be stored at room temperature and has a shelf life of 5 days after thawing.

Methods
We identified locations and specific end users with high cryoprecipitate utilization and waste. We partnered with our blood supplier to use IFC in these locations. We analyzed waste and turnaround time before and after implementation.

Results
Operative locations had a waste rate that exceeded nonoperative locations (16.7% vs 3%) and were targeted for IFC implementation. IFC was added to our inventory to replace all cryo orders from adult operating rooms, and waste decreased to 2.2% in these locations. Overall waste of cryoprecipitated products across all locations was reduced from 8.8% to 2.4%. The turnaround time for cryoprecipitated products was reduced by 58% from 30.4 minutes to 14.6 minutes.

Conclusions
There has been a substantial decrease in waste with improved turnaround time after IFC implementation. This has improved blood bank logistics, improved efficiency of patient care, and reduced costly waste.