bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of macular vessel density among patients with glaucoma, ocular hypertension, and normal participants
Authors: Elsayed Wesam S. , Nassar Moustafa K. , Ibrahim Asmaa M.A. , El-Aziz Mohammed S.A. 
Published: July 2024

Purpose
To assess macular vessel density (VD) in open-angle glaucoma (OAG), normal tension glaucoma (NTG), ocular hypertension (OHT), and normal participants by using optical coherence tomography angiography (OCTA).

Setting and design
This observational case–control study was conducted at Menoufia University, Faculty of Medicine, Department of Ophthalmology.

Patients and methods
Patients who received OCTA were already diagnosed with glaucoma and were divided into four groups: OAG group, NTG group, OHT group, and normal participants’ group. The ophthalmic parameters, which include best-corrected visual acuity, intraocular pressure, visual field mean deviation, retinal nerve fiber layer thickness, and ganglion cell complex thickness, were recorded. About the macula, the superficial VD, deep VD, and foveal avascular zone (FAZ) were evaluated via OCTA and analyzed by utilizing the default VD analysis program in the same OCTA.

Results
This study was conducted on 152 eyes, 38 eyes with OAG, 38 eyes with NTG, 38 eyes with OHT, and 38 normal participant eyes. Significant decrease in retinal nerve fiber layer thickness and ganglion cell complex thickness were noticed in OAG and normal tension groups cases. The OAG and NTG groups revealed a reduction in superficial VD and a reduction in deep VD compared to the OHT and the controls. No difference in the FAZ was noticed among all the studied groups.

Conclusion
Impaired macular circulation was demonstrated in the OAG and NTG patients compared to OHT patients and normal participants. No difference in FAZ among the glaucoma cases and normal individuals.
Comparison Study of the Inflammatory Biomarkers and Cytokine Levels in COVID-19 Patients
Authors: Mahdi Dheyaa Saleh , Al-Shawk Refif Sabih , Hamid Zainab A. , Abed Suha Maher 
Published: July 2024

Abstract

Background:
ACOVID-19, caused by the novel coronavirus SARS-CoV-2, presents with varying severity, from mild symptoms to severe disease, including ARDS and multi-organ failure. Identifying early biochemical markers to predict the severity of COVID-19 is crucial for improving patient outcomes.

Aims and Objectives:
The study aimed to identify distinct patient groups with COVID-19 and healthy controls using cluster analysis of multiple biomarkers. Specifically, it sought to determine if early detected levels of ferritin, D-dimer, and C-reactive protein (CRP) are associated with the severity of COVID-19.

Materials and Methods:
Biochemical profiles of sixty patients with SARS-CoV-2 RNA-positive testing and thirty healthy controls were collected and analyzed. Two-dimensional automated hierarchy clustering was performed on all biomarkers. The study focused on alterations in the biochemistry markers ferritin, D-dimer, and CRP. Additionally, levels of inflammatory cytokines, particularly interleukin-6 and tumor necrosis factor-alpha, were measured.

Results:
Ferritin, D-dimer, and CRP levels were significantly higher in COVID-19 patients compared to the control group. Early detected levels of these biomarkers were associated with a higher incidence of severe COVID-19. Elevated levels of inflammatory cytokines, especially interleukin-6 and tumor necrosis factor-alpha, were also observed in COVID-19 patients, indicating the presence of a cytokine storm, which is a major cause of organ dysfunction and mortality in severe cases.

Conclusion:
Our findings suggest that elevated levels of ferritin, D-dimer, and CRP are indicative of severe COVID-19. Early detection of these biomarkers can help predict the severity of the infection and guide clinical management. The study also underscores the significant role of inflammatory cytokines in the pathogenesis of COVID-19, contributing to the understanding of the cytokine storm that leads to severe disease outcomes.
Exploring Drug Repurposing Through Artificial Intelligence: A Novel Approach to Treating Herpes Zoster Infection
Authors: Daungsupawong Hinpetch , Wiwanitkit Viroj 
Published: July 2024

Abstract

Background:
This study evaluates the potential of ChatGPT, an artificial intelligence (AI) language model, to assist health-care professionals in selecting appropriate medications for the management of herpes zoster. Agroup of experts specializing in dermatology and infectious diseases assess the recommendations provided by ChatGPT for ten hypothetical clinical scenarios involving herpes zoster.

Aims and Objectives:
The main objective is to determine the extent to which ChatGPT can contribute to informed decision-making when it comes to repurposing drugs for the treatment of this condition.

Materials and Methods:
The accuracy and relevance of ChatGPT’s suggestions are evaluated by comparing them to current medical research and literature.

Results:
The findings indicate that ChatGPT consistently offers valuable recommendations for potential drug repurposing in the management of herpes zoster, aligning with scientific evidence and published literature. While there may be limitations in terms of therapeutic options and the inability to customize treatment plans, health-care professionals find ChatGPT’s guidance beneficial in identifying potential repurposed drugs. However, it is important to address these limitations, such as the need for more clinical data and the ability to customize treatment plans. Further research is necessary to enhance ChatGPT’s effectiveness in managing herpes zoster.

Conclusion:
Future studies should focus on refining the model’s capabilities, incorporating comprehensive clinical data, and enabling customization of treatment plans to make ChatGPT a valuable resource for health-care professionals dealing with herpes zoster.
Síndrome Charge e cardiopatias congênitas: revisão sistemática da literatura
Authors: Rezende Thrícia Christina Garcia Diniz , Christovam Éttore Rosanova , Paula Mariliane Nascimento de , Silva Isabela Teixeira dos Santos 
Published: July 2024

Introdução: As cardiopatias congênitas são frequente causa de malformações presentes no nascimento e que podem gerar uma alta taxa de mortalidade no primeiro ano de vida, hospitalizações. Tem-se como exemplo a Síndrome de Charge, que é uma anomalia genética rara, com prevalência de 1 para 15.000 nascidos vivos. As principais alterações são problemas cardíacos, atresia de canas, restrição de crescimento e desenvolvimento, colomba de íris, anomalias genitais e alterações na orelha. Diante do diagnóstico, é necessário que os pacientes recebam cuidados multidisciplinares. Objetivo: O presente artigo tem por objetivo uma revisão sistemática de literatura a respeito do conhecimento sobre a síndrome e as cardiopatias congênitas. Materiais/sujeitos e métodos: Foram consultados artigos científicos e artigos de revisão publicados e referenciados na PubMed entre janeiro de 2005 e novembro de 2017. A pesquisa dos artigos foi realizada com o filtro de “Charge Syndrome and Congenital Heart Defects”. Resultados e discussão: Considerações finais: O suporte e acompanhamento contínuo de uma equipe multidisciplinar é essencial, promovendo o acesso a terapias e cuidados singulares que auxiliarão na manutenção da inclusão e da qualidade de vida dos portadores dessa alteração e de familiares envolvidos.
Mídias sociais na insuficiência cardíaca: uma revisão sistemática
Authors: Vieira Luisa Raquel Saldanha Alves Bastos , Ruivo Laís Grabner , Lopes Matheus de Freitas , Queiróz Júlia Leitão , Soares Bernardo Mussi 
Published: July 2024

Introdução: A insuficiência cardíaca é considerada uma condição crônica e progressiva, que acomete mais de 26 milhões de pessoas no mundo. As mídias sociais podem ser usadas como ferramentas para compartilhamento de informação, inclusive entre profissionais da saúde especializados e pacientes portadores de insuficiência cardíaca. Objetivo: O presente artigo possui como objetivo acessar o conteúdo produzido em mídias sociais a respeito dessa patologia e determinar a associação entre o uso das plataformas e o acometimento cardiovascular. Materiais/sujeitos e métodos: Para a realização desse estudo foi realizada revisão sistemática com pesquisa em bases de dados como PubMed, Embase SciELO e Medline utilizando os termos "cardiologia", "mídias sociais" e "insuficiência cardíaca". Também foram feitas pesquisas em mídias sociais como o Twitter com hashtags relacionadas ao assunto. Resultados e Discussão: A maior parte das plataformas concentra-se na capacitação profissional e, em menor parte, na informação dos pacientes. Quando um conteúdo é produzido por um paciente, esse normalmente é direcionado a outro paciente, o que torna a informação unidirecional. Considerações Finais: O uso das mídias sociais pode participar da instrução profissional e conscientização do paciente, podendo diminuir o risco de insuficiência cardíaca, especialmente em mulheres. Pacientes considerados isolados devem buscar maior envolvimento em mídias sociais para melhor qualidade de vida.
Envenenamento por picada de cobra e coração: revisão sistemática
Authors: Ramos Larissa Feitosa de Albuquerque Lima , Baldini João Carlos Cardoso , Caldas Luísa Wagner Borges , Gonçalves Ana Luiza Lima 
Published: July 2024

Introdução: Os acidentes ofídicos, considerados um importante problema de saúde pública, ocorrem especialmente em áreas rurais e países em desenvolvimento. Trata-se de uma doença tropical negligenciada, com elevadas taxas de morbidade e mortalidade, mesmo diante da existência de subnotificação no Sistema de Informação de Agravos de Notificação. As repercussões clínicas e prognósticas dependem do local anatômico da picada, grau de inoculação do veneno, propriedades específicas, toxicocinética, da composição e potência, tempo entre o acidente e o tratamento, apresentando diferentes efeitos locais e sistêmicos. No que tange à cardiotoxicidade e suas repercussões no sistema cardiovascular, poucos são os estudos encontrados. Objetivo: O presente artigo objetiva, portanto, apresentar uma revisão da literatura científica sobre os acidentes ofídicos e seus efeitos no coração, utilizando a metodologia qualitativa. Materiais/sujeitos e métodos: Foram analisados revistas acadêmicas e artigos científicos e de revisão, publicados em bases de dados Medline/PubMED, SciELO e outros, no período entre 2011 e novembro de 2023, além do Manual de diagnóstico e tratamento de acidentes por animais peçonhentos do Ministério da Saúde, de 2001. Resultados e discussão: Os efeitos cardiotóxicos dos venenos de cobra são diversos e complexos, exigindo um conhecimento profundo para melhorar os tratamentos disponíveis. O reconhecimento precoce e o manejo adequado dos pacientes exigem uma abordagem individualizada e multidisciplinar, levando em consideração os riscos e benefícios de cada opção terapêutica. Assim, inobstante a eficácia da terapia antiveneno, é fundamental observar, na literatura científica, a abordagem das limitações no manejo clínico dos pacientes vítimas de acidentes ofídicos, considerando, também, a composição e a toxicocinética nos diferentes tecidos e órgãos. Considerações finais: Assim, embora seja raro, é importante estarmos atentos à possibilidade de um acidente ofídico desencadear um evento coronário. A administração precoce do soro antiofídico e a monitoração cuidadosa das alterações na coagulação são fundamentais para o tratamento adequado dos pacientes.
Kapasitas Kelembagaan Universitas Negeri Padang Dalam Mengakomodasi Pendidikan Inklusif Kepada Penyandang Disabilitas
Authors: Deprianto Deprianto , Sasmita Siska 
Published: July 2024

Penelitian ini dilatarbelakangi oleh kesulitan yang dihadapi oleh mahasiswa penyandang disabilitas dalam mengakses layanan akademik dan layanan kemahasiswaan di Universitas Negeri Padang. Penelitian ini bertujuan untuk mengetahui kapasitas kelembagaan Universitas Negeri Padang dalam mengakomodasi pendidikan inklusif kepada penyandang disabilitas. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Teknik pengumpulan data yang digunakan adalah wawancara, studi dokumentasi dan observasi. Informan dalam penelitian ini meliputi Sekretaris UNP, Lembaga Pengembangan Pendidikan Pelaksana Tugas Strategis UNP, Pusat Layanan Disabilitas UNP, Pejabat Pengelola Informasi dan Dokumentasi UNP, Direktur Umum Biro Akademik UNP, Biro Perencanaan dan Kerjasama UNP, Biro Kemahasiswaan dan sejumlah mahasiswa penyandang disabilitas. Data dianalisis menggunakan Teori Kapasitas Kelembagaan dari Lewis dan Cowens (1985) dengan enam dimensi kapasitas kelembagaan yaitu: 1) kondisi informasi, 2) kondisi komunikasi, 3) kondisi simetri, 4) kondisi penegakan dan pencegahan, 5) kondisi pemantauan 6) pengaruh kumulatif dari kondisi. Hasil penelitian menunjukkan tidak terpenuhinya kapasitas kelembagaan UNP dalam memberikan layanan akademik dan layanan kemahasiswaan bagi mahasiswa penyandang disabilitas. Namun, UNP tengah mengupayakan perbaikan layanan akademik dan kemahasiswaan untuk mengakomodasi kesetaraan dalam bidang pendidikan.
EVENTOS INFECCIOSOS EN PACIENTES CON TRATAMIENTO EN HEMODIÁLISIS ASOCIADOS AL AUTOCUIDADO SEGÚN LA TEORÍA DE DOROTHEA OREM. UNA REVISIÓN SISTEMÁTICA
Authors: Álvarez Reyes Angie Lizeth , Mireya Coromoto Alejo De Mujica , López Damián Franklin Javier , Quille Patín Elvia Aexandra 
Published: July 2024

La enfermedad renal crónica (ERC) se considera una afección que altera el funcionamiento correcto de los riñones y para ello se intervienen tratamientos como la hemodiálisis para mejorar la azotemia, anomalía de líquidos, electrolitos y acido-bases, característicos del síndrome urémico. La presente investigación tiene como objetivo analizar los eventos infecciosos más comunes en pacientes con tratamiento en hemodiálisis asociados al autocuidado, según la teoría de Dorothea Orem. La metodología se llevó a través de una revisión sistemática bajo el método PRISMA que se sustenta en 30 estudios científicos obtenidos de Scopus, Scielo, PubMed y Google Books, mismas que presentan información validada y actualizada de los últimos 5 años. Se presenta información de pacientes que implementaron un programa de intervención para reducir las principales infecciones de catéter a causa de agentes patógenos como el Staphylococcus y E. Coli en los accesos vasculares (40,01 %). También se destaca la eficacia de las intervenciones del autocuidado, basadas en la teoría de Orem en la que involucra el control del consumo de alimentos y líquidos, cuidados de la piel con la higiene personal, el tiempo de descanso con la calidad de sueño y la comunicación con la relación interpersonal, esto con la finalidad de mejoras sustanciales en la calidad de vida de pacientes. En conclusión, este estudio subraya la necesidad de enfoques de atención más personalizados y efectivos para abordar los desafíos específicos que enfrentan los pacientes con insuficiencia renal crónica durante la hemodiálisis.
Mengatasi Tantangan Gizi: Peran Kunci Masyarakat dalam Pencegahan Stunting
Authors: Solikhah  , Nindy Vigita 
Published: July 2024

Kegiatan pengabdian kepada masyarakat (PkM) dilakukan untuk meningkatkan kesadaran masyarakat tentang pentingnya memerangi stunting. Metode pelaksanaan menggunakan penyuluhan terkait Mengatasi Tantangan Gizi melalui Peran Kunci Masyarakat dalam Pencegahan Stunting. Penyuluhan dilakukan pada tanggal 6 Februari 2024. Kegiatan dihadiri 15 orang di Dusun Nglinggo Timur, Pagerharjo, Kecematan Samigaluh, Kabupaten Kulon Progo DIY, yang dilaksanakan di rumah kepala dusun. Tim PkM terdiri satu ketua PkM dan dibantu oleh 9 mahasiswa Kuliah Kerja Nyata Reguler 119 dari unit ditempatkan di Nglinggo Timur, Pagerharjo Kecamatan Samigaluh, Kabupaten Kulon Progo DIY. Kegiatan PkM ini berjalan lancar, dan masyarakat terlibat aktif dalam penyuluhan, seperti yang ditunjukkan oleh diskusi interaktif peserta. Hasil pre-test dan post-test menunjukkan bahwa masyarakat lebih tahu dan tahu bagaimana mencegah stunting dan bahwa mereka semakin peduli dengan pengelolaan bahan pangan. Kedepan, edukasi terus dilakukan secara kontinyu untuk emnurunkan angka stunting.
Sosialisasi GERCEP Stunting (Gerak Cegah dan Penanganan Stunting)
Authors: Prasetyo Aries , Indraswati Denok , Handoyo  , Sujangi  
Published: July 2024

Stunting dan masalah kekurangan gizi lainnya masih menjadi masalah kesehatan masyarakat yang diperhatikan secara global. Sebanyak 149,2 juta balita di dunia diperkirakan mengalami stunting. Masih adanya balita yang stunting di Desa Mitra maka perlu dilakukannya peningkatan pengetahuan tentang stunting sebagai pencegahan. Tujuan dalam kegiatan pengabdian masyarakat ini adalah meningkatkan pengetahuan ibu balita tentang Stunting. Metode yang digunakan pre-test dilanjutkan ceramah dan tanya jawab menggunakan power point mengenai pencegahan Stuntung, selanjutnya diakhiri dengan post-test. Hasil dalam kegiatan pengabdian masyarakat ini responden yang memperoleh skor baik pada pre-test sebesar 73,7% meningkat menjadi 97,4% responden pada hasil skor post-test. Sehingga didapatkan simpulan terdapat peningkatan skor responden antara pre-test dan post-test dan warga mitra terutama ibu balita untuk menerapkan pola asuh makan balita yang benar.
Colonialidad y género: Relaciones entre Zama (1956) de Antonio Di Benedetto y Zama (2017) de Lucrecia Martel
Authors: D’Alessandro Natalia 
Published: July 2024

En este artículo pondré en diálogo la novela Zama de Antonio Di Benedetto con su reescritura cinematográfica: Zama de Lucrecia Martel. Como punto de partida, tomo un interrogante de Rita Segato que se relaciona íntimamente con ciertas políticas cinematográficas de la adaptación de Martel y que debate cuáles son las formas en las que el arte contemporáneo –y sus trabajos e intervenciones en torno al género– pueden desarticular la colonialidad del poder. Creo que Zama busca respuestas a estos interrogantes. Para indagar en ello, observaré un cambio fundamental en el pasaje de novela a film: Martel elimina la primera persona, prescinde de Diego de Zama –varón heterosexual– como narrador protagonista. El fuerte “yo” de la novela deviene en el film en un colectivo de voces diverso y amplísimo: voces de mujeres, niños y niñas, indígenas, esclavos y esclavas. ¿Hacia qué conclusiones nos llevan estas políticas cinematográficas?
IMPLEMENTASI PENTAS SENI TARI SEBAGAI WADAH KREATIVITAS DAN KEPERCAYAAN DIRI BAGI ANAK USIA DINI
Authors: JELITA DEA PUTRI , SIREGAR SITI MAHPUDZOH , ANDINI ZYHAN RISTY , LUBIS HILDA ZAHRA 
Published: July 2024

Performing arts can be a place to increase children's creativity and self-confidence. Dance performances can be a place for children to express themselves through movement and become more confident in front of the general public. Therefore, the aim of this research is that researchers want to analyze in detail the implementation of dance performances as a forum for increasing the creativity and self-confidence of young children. The research subjects of this research were children from groups A and B RA Khusnul Hafzhan, as well as teachers. The method used in this research is a qualitative method with a descriptive qualitative approach. Qualitative analysis, analysis of the data used in this research. Data analysis was carried out by means of data reduction, data presentation, and drawing conclusions. The data collection techniques used are interviews, observation and documentation. The research results show that the implementation of dance performances can be a forum for children to increase their creativity and self-confidence, not only for indoor arts performances, but also for outdoor arts performances or in other words dance competitions for young children.
ABSTRAKPentas seni dapat menjadi wadah untuk meingkatkan kreativitas dan kepercayaan diri anak. Pentas seni tari bisa menjadi tempat bagi anak untuk mengekpresikan diri melalui gerakan dan lebih percaya diri didepan khalayak umum. Maka dari itu, tujuan dari riset ini adalah peneliti ingin menganalisis secara mendetail, implementasi pentas seni tari sebagai wadah untuk meningkatkan kreativitas dan kepercayaan diri anak usia dini. Subjek penelitian dari riset ini adalah anak anak kelompok A dan B RA Khusnul Hafzhan, serta guru. Metode yang digunakan pada riset ini adalah metode kualitatif dengan pendekatan kualitatif deskriptif. Analisis kualitatif, Analisis data yang dipakai di penelitian kali ini. Analisis data dilakukan dengan cara reduksi data, penyajian data, dan penarikan kesimpulan. Teknik pengumpulan data yang digunakan ialah wawancara, observasi dan dokumentasi. Hasil penelitian menunjukkan bahwa implementasi pentas seni tari dapat menjadi wadah bagi anak untuk meningkatkan kreativitas dan kepercayaan dirinya, tidak hanya untuk pentas seni indoor, tetapi juga untuk kegiatan pentas seni outdoor atau dengan kata lain ajang perlombaan seni tari bagi anak usia dini.
Sensitivity analysis of a Martian atmospheric column model with data from the Mars Science Laboratory
Authors: Leino Joonas , Harri Ari-Matti , Paton Mark , Polkko Jouni , Hieta Maria , Savijärvi Hannu 
Published: July 2024

Abstract. An extensive sensitivity analysis was performed for a horizontally homogeneous and hydrostatic 1-D column model at the Mars Science Laboratory (MSL) location. Model experiments were compared with observations from the Curiosity Rover Environmental Monitoring Station humidity (REMS-H) device and ChemCam. Based on our earlier column model investigations, model surface temperature and pressure, dust optical depth (τ), and column precipitable water content (PWC) were the parameters that we investigated with our sensitivity analysis. Our analysis suggests that the most sensitive parameters for the column model temperature profile are τ and surface temperature. The initial value of PWC does not affect the temperature profile of the model, but it is the most important parameter for the humidity profile. The fixed value of τ also seems to have some effect on the humidity profile of the model. Based on our analysis, variations in surface pressure initialization are negligible for the model's temperature and almost negligible for the model's humidity predictions. The model simulations are generally in good agreement with the observations. Our additional model experiments with a different shape of the model's initial humidity profile yielded better results compared to the well-mixed assumption in the predicted water vapor volume mixing ratios at 1.6 m.
On the power and control of a misaligned rotor – beyond the cosine law
Authors: Tamaro Simone , Campagnolo Filippo , Bottasso Carlo L. 
Published: July 2024

Abstract. We present a new model to estimate the performance of a wind turbine operating in misaligned conditions. The model is based on the classic momentum and lifting-line theories, considering a misaligned rotor as a lifting wing of finite span, and accounts for the combined effects of both yaw and uptilt angles. Improving on the classical empirical cosine law in widespread use, the new model reveals the dependency of power not only on the misalignment angle, but also on some rotor design parameters and – crucially – on the way a rotor is governed when it is yawed out of the wind. We show how the model can be readily integrated with arbitrary control laws below, above, and around the rated wind speed. Additionally, the model also shows that a sheared inflow is responsible for the observed lack of symmetry for positive and negative misalignment angles. Notwithstanding its simplicity and insignificant computational cost, the new proposed approach is in excellent agreement with large eddy simulations (LESs) and wind tunnel experiments. Building on the new model, we derive the optimal control strategy for maximizing power on a misaligned rotor. Additionally, we maximize the total power of a cluster of two turbines by wake steering, improving on the solution based on the cosine law.