bluuebunny/crossref_metadata_2025_split huggingface dataset:
The history of interferon-stimulated genes in pregnant cattle, sheep, and pigs
Authors: Johnson Gregory A , Bazer Fuller W , Burghardt Robert C , Seo Heewon , Wu Guoyao , Cain Joe W , Pohler Ky G 
Published: July 2024

In Brief
The trophectoderm of the elongating conceptuses of cattle, sheep, and pigs secrete high amounts of interferons that increase or induce the expression of interferon-stimulated genes (ISGs) in the endometrium. Research concerning ISGs, performed from 1995 through 2023, is reviewed in this manuscript.

Abstract
Expression of the classical interferon (IFN) stimulated genes (ISGs) increases in the endometrial stroma and glandular epithelium (GE) through activation of signal transducer and activator of transcription (STAT) signaling in response to the secretion of IFN tau (IFNT) and IFN gamma (IFNG) by the conceptuses of ruminants, including cattle and sheep, and pigs, respectively. The first of the classical ISGs to be characterized was ISG15 in cattle. Classical ISGs are not expressed by the endometrial luminal epithelium (LE) due to the expression of interferon regulatory factor 2 (IRF2) in the LE that prevents the expression of ISGs in the LE. Classical ISG expression in the endometrium serves as a reliable indicator of conceptus health and elongation in cattle. There are also nonclassical ISGs that are upregulated in endometrial LE in response to progesterone (P4) that are further stimulated by IFNT in sheep, the intracellular signaling pathway responsible for IFN effects on expression is unknown. ISGs are also upregulated in extrauterine tissues including CL and peripheral blood mononuclear cells (PBMCs). The expression of ISGs by the PBMCs of cattle serves as an early prognosticator of pregnancy. The physiological roles of ISGs remain obscure, but evidence suggests that they are at least in part involved in modifying the immune system to support endometrial remodeling necessary for the successful implantation of the conceptus. Our understanding of these ISGs is primarily the result of work from the laboratories of Drs Fuller Bazer, Thomas (Tod) Hansen, Gregory Johnson, Hakhyun Ka, Patrick Lonergan, Troy Ott, and Thomas Spencer.
Los nuevos sujetos educativos para las transiciones a la paz
Authors: Moya Urueña Daniel 
Published: July 2024

Reconociendo las limitantes al hablar de “transición” para describir lo que acontece en Colombia en el marco del conflicto armado—uno de los más longevos y sangrientos del mundo moderno—, no por ello se desconoce la coyuntura en la que la sociedad colombiana se encuentra: un pasado y presente de graves y sistemáticas violaciones a los derechos humanos y al derecho internacional humanitario (DIH) por parte de los grupos armados legales e ilegales, lo que impone la necesidad de la reflexión y debate colectivo para comprender el camino hacia adelante. La educación, por supuesto, no queda exenta de esta responsabilidad histórica y se convierte, más bien, en escenario de nuevos sujetos y procesos educativos para facilitar la compleja y difícil transición a la paz.
En este artículo se exponen algunas bases ético-políticas de la construcción de paz, pensadas desde el ejercicio docente universitario. Se refiere a la educación frente a los retos que esta puede asumir en las transiciones a la paz. Luego, se mencionan algunas experiencias significativas que se han liderado desde la Universidad Santo Tomás (USTA), seccional Tunja, en pedagogía e investigación para la paz, incluyendo la cátedra de paz en alianza con los mecanismos de justicia transicional. Se concluye con reflexiones sobre los nuevos sujetos educativos que emergen en las transiciones a la paz.
MACHINE LEARNING METHODS FOR COMPENSATING SIGNAL DISTORTIONS IN FIBER-OPTIC COMMUNICATION LINES
Authors: СИДЕЛЬНИКОВ О.С. , РЕДЮК А.А. , ФЕДОРУК М.П. 
Published: July 2024

В статье затронуты актуальные проблемы в области волоконно-оптической передачи данных, связанные с постоянным ростом спроса на пропускную способность систем связи и их нелинейным откликом. Представлены основные методы машинного обучения, используемые для компенсации нелинейных искажений сигнала в когерентных линиях связи большой протяжённости, включая нейронные сети различной архитектуры. В работе подчёркнута перспективность решений на основе методов машинного обучения для увеличения производительности оптоволоконных систем связи, благодаря их способности получать эффективные и адаптивные схемы восстановления сигнала с низкой вычислительной сложностью.
The article addresses current issues in the field of fiber-optic data transmission, related to the constant increase in demand for communication system bandwidth and nonlinear response. The main machine learning methods used to compensate for nonlinear signal distortions in long-haul coherent communication lines are presented, including neural networks of various architectures. The paper emphasizes the promising nature of machine learning-based solutions to enhance the performance of optical fiber communication systems, thanks to their ability to derive effective and adaptive signal recovery schemes with low computational complexity.
Efeitos da violência doméstica contra a mulher e a incidência de transtorno depressivo
Authors: Rayol Campana Pires Fernanda , Teixeira Evandro Camargos 
Published: July 2024

O objetivo deste estudo foi estabelecer a relação entre o diagnóstico de depressão em mulheres vítimas de violência doméstica por meio da revisão sistemática de literatura e da metanálise. Foram realizadas buscas nas bases de dados Web of Science, PubMed e Scopus usando as seguintes palavras-chave: (“domestic violence” OR “intimate partner violence”) AND (depression). É importante salientar que a metodologia segue o modelo PRISMA e utilizou o Software StArt para o tratamento dos dados encontrados. Obteve-se uma amostra de 10 artigos internacionais em que foram discutidos os resultados obtidos pelos autores. Posteriormente, esses estudos foram sintetizados estatisticamente de modo a aumentar a precisão das informações. Os resultados mostraram que mulheres que sofrem violência doméstica estão mais sujeitas a desenvolver depressão em comparação com aquelas que não sofrem com a violência. Dessa forma, conclui-se que existem diversos fatores sociodemográficos e econômicos que contribuem para o agravamento da saúde mental e o diagnóstico de depressão.
Las terapias cognitivas: mitos y aspectos controvertidos
Authors: Ferrer Botero Alberto 
Published: July 2024

El artículo se centra sobre cuatro mitos y aspectos controvertidos de la Terapia Cognitiva. En el primero de ellos se cuestiona las concepciones que sostienen que las Terapias Cognitivas son solo una técnica de reestructuración cognitiva, que pertenece a la terapia o a la modificación de la conducta, y que por lo tanto no tienen un modelo teórico ni una metodología propia. En el segundo, que la causa del comportamiento y de las emociones es el pensamiento. En el tercero, se concluye que no es cierto que el terapeuta cognitivo irrespete al paciente porque le impone sus criterios. En el cuarto, se muestra que no es cierto que las Terapias Cognitivas se olviden de los aspectos no racionales del ser humano, y que pretendan volverlo un procesador frío y lógico de la información.
Effects of an Chinese Herbal Compound Prescription on Simulated Transport Stress in Mice
Authors: Jiang Xiao-Fei , Pan Wan-Ying , Teng Shu-Xue , Cao Jian-Feng 
Published: July 2024

Background: In order to alleviate the transport stress reaction of animals, three kinds of chinese herbs with sedative and tranquilizing properties were extracted with ethanol and proportionally composed into a chinese herbal compound prescription. In addition, isorhynchophylline in leaves of Uncaria rhynchophylla was isolated and purified for use. Methods: The enzyme-linked Immunosorbent assay (ELISA) was used to measure the changes in serum stress indicators and hormone levels, three classification blood cell counter and automatic biochemistry analyser was used to measure blood indicators and other biochemical indicators of each group mice before and after transport stress. Result: The results showed that the blood physiological indexes such as blood glucose (GLU) level, biochemical indexes such as lactate dehydrogenase (LDH) and hormone levels such as adrocorticotropic hormone (ACTH) and other stress indexes were significantly higher in mice after transport than before. The compound agents and isorhynchophylline played a role in regulating the stress indices of mice after the simulating transport processs and have the effect of significantly alleviating the transport stress response in mice, with a view to provide reference for alleviating the adverse effects of transport stress on the animal husbandry industry.
Gender Disparity in Authorship Among Orthopaedic Surgery Residents
Authors: Cho Elizabeth , McCarthy Mary V. , Hodkiewicz Victoria , Rumps Mia V. , Mulcahey Mary K. 
Published: July 2024

Background:
Gender disparity remains pervasive in orthopaedic surgery, which affects the research pursuits of orthopaedic surgeons. The purpose of this study was to characterize gender-related authorship trends of orthopaedic surgery residents, including evaluation of gender-concordant publication rates.

Methods:
An observational cross-sectional analysis of US orthopaedic surgery residency programs was performed. Information on residency programs and demographics of each cohort was collected. Publication metrics consisting of number of first and non-first author publications and H-indices were manually obtained for PGY-3 to PGY-5 residents attending the 25 programs ranked the highest for research output by Doximity. Gender of each resident and senior author was determined from institutional websites using photos, biographies, and preferred pronouns when available.

Results:
A total of 532 residents, 169 (31.8%) female and 363 (68.2%) male, were included for authorship analysis. Of them, 415 (78%) had at least one first author publication, which did not vary significantly by gender. Female residents had disproportionately fewer first author publications compared with their representation (22% vs. 31.8%, p < 0.00001). Female residents averaged fewer first and non-first author publications compared with male residents (2.8 vs. 4.6, p = 0.0003; 6.4 vs. 10, p = 0.0001 respectively). Despite fewer publications overall, a greater subset of publications by female residents were written in collaboration with a female senior author compared with publications by male residents (p < 0.0001). Male residents had a higher average H-index of 5.4 vs. 3.9 among female residents (p = 0.00007).

Conclusion:
Despite similar rates of first author publication among male and female residents, female residents had fewer publications overall, lower H-indices, and disproportionately fewer first author publications than would be expected given their representation. Findings from this study suggest that gender disparity in orthopaedic surgery extends to differences in research productivity as early as in residency. This may have negative implications on the career advancement of female orthopaedic surgeons. Additional work is needed to identify and understand biases in research productivity and career advancement, to promote more equitable strategies for academic achievement.

Level of Evidence:
IV.
Ubiquitin-Proteasome System in the Different Stages of Dominantly Inherited Alzheimer’s Disease
Authors: McDade Eric , Liu Haiyan , Bui Quoc , Hassenstab Jason , Gordon Brian , Benzinger Tammie , Shen Yuanyuan , Timsina Jigyasha , Wang Lihua , Sung Yun Ju , Karch Celeste , Renton Alan , Daniels Alisha , Morris John , Xiong Chengjie , Ibanez Laura , Perrin Richard , Llibre-Guerra Jorge J , Day Gregory , Supnet-Bell Charlene , Xu Xiong , Berman Sarah , Chhatwal Jasmeer , Ikeuchi Takeshi , Kasuga Kensaku , Niimi Yoshiki , Huey Edward , Schofield Peter , Brooks William , Ryan Natalie , Jucker Mathias , Laske Christoph , Levin Johannes , Vӧglein Jonathan , Roh Jee Hoon , Lopera Francisco , Bateman Randall , Cruchaga Carlos 
Published: July 2024

Abstract

This study explored the role of the ubiquitin-proteasome system (UPS) in dominantly inherited Alzheimer’s disease (DIAD) by examining changes in cerebrospinal fluid (CSF) levels of UPS proteins along with disease progression, AD imaging biomarkers (PiB PET, tau PET), neurodegeneration imaging measures (MRI, FDG PET), and Clinical Dementia Rating® (CDR®). Using the SOMAscan assay, we detected subtle increases in specific ubiquitin enzymes associated with proteostasis in mutation carriers (MCs) up to two decades before the estimated symptom onset. This was followed by more pronounced elevations of UPS-activating enzymes, including E2 and E3 proteins, and ubiquitin-related modifiers. Our findings also demonstrated consistent correlations between UPS proteins and CSF biomarkers such as Aβ42/40 ratio, total tau, various phosphorylated tau species to total tau ratios (ptau181/T181, ptauT205/T205, ptauS202/S202, ptauT217/T217), and MTBR-tau243, alongside Neurofilament light chain (NfL) and the CDR®. Notably, a positive association was observed with imaging markers (PiB PET, tau PET) and a negative correlation with markers of neurodegeneration (FDG PET, MRI), highlighting a significant link between UPS dysregulation and neurodegenerative processes. The correlations suggest that the increase in multiple UPS proteins with rising tau levels and tau-tangle associated markers, indicating a potential role for the UPS in relation to misfolded tau/neurofibrillary tangles (NFTs) and symptom onset. These findings indicate that elevated CSF UPS proteins in DIAD MCs could serve as early indicators of disease progression and suggest a link between UPS dysregulation and amyloid plaque, tau tangles formation, implicating the UPS as a potential therapeutic target in AD pathogenesis.
Hybrid Filtering Techniques and Improved SOM for Next-Generation Film Recommendations
Authors: SHARMA SAURABH , SHARMA SAURABH , SHARMA SAURABH , SHARMA SAURABH 
Published: July 2024

Abstract

Personalized movie recommendations are becoming increasingly important for increasing user satisfaction and engagement in an era where entertainment content is becoming more digitally connected. This work presents a novel approach to facilitate movie selection through the use of Enhanced Self-Organizing Maps (SOM). SOMs, or unsupervised neural network architectures, are helpful in recommendation systems because of their ability to recognize intricate patterns in data. The methodology described in this paper starts with gathering user-movie interaction data, such as user ratings and movie characteristics. This data is normalized before being used to train the model in order to preserve homogeneity. Subtle patterns in data can be effectively identified by the Enhanced SOM due to its adjustable learning rate and neighborhood function. The Enhanced SOM's capacity to identify related users and movies is used to generate personalized movie suggestions. The framework's incorporation of hybrid filtering approaches improves the caliber of recommendations. While content-based filtering uses movie attributes like genres and descriptions, collaborative filtering algorithms take advantage of user-item interactions. These methods yield recommendations that synergistically combine multiple filtering processes. The efficacy of the proposed resolution is meticulously evaluated by contrasting the precision of the recommendations and user contentment with pre-established standards. A thorough evaluation of real-world datasets supports the efficacy of the Enhanced SOM-based movie recommendation technique. To further enhance suggestion quality, the system offers options to modify grid sizes, neighborhood functions, and parameters. When taken as a whole, these features demonstrate how successful the suggested approach is in making personalized movie recommendations. Enhanced SOMs are a reliable model for content platforms that want to enhance user experiences by offering precise movie recommendations along with scalability and flexibility when paired with hybrid filtering techniques.
Heterologous expression of banana MaDREB16 gene in Arabidopsis increases tolerance to dehydration and combined dehydration plus heat stress through stomatal regulation and root elongation
Authors: Chaudhari Rakesh Shashikant , Jangale Bhavesh Liladhar , Krishna Bal , Sane Prafullachandra Vishnu 
Published: July 2024

Abstract

We report here isolation of a dehydration responsive element binding 2 (DREB2) gene (MaDREB16) from Grand Nain (GN) cultivar of Musa acuminata and its involvement in dehydration and heat stress responses in transgenic Arabidopsis plant. Expression analysis of MaDREB16 in root tissues of two banana varieties showed its significant expression under dehydration and combined dehydration plus heat stress. Our findings demonstrate that soil grown transgenic Arabidopsis plants overexpressing MaDREB16 gene display better rate of survival, aerial dry biomass, seed production, relative water content and content of free proline, whereas it has lower ion leakage and malondialdehyde content under the stress conditions studied. Transgenic Arabidopsis plants also showed significant induction of downstream marker genes under dehydration, heat as well as their combination of stresses. Transgenic Arabidopsis displayed reduced stomatal densities and indices even under unstressed conditions suggesting that the transgene modifies the stomatal characteristics and improved regulation of stomatal aperture in dehydration stress as compared to wild-type Arabidopsis. These alterations may be accountable for the observed improved tolerance against individual and combined stress studied.in transgenic as compared to the wild-type. Interestingly the transgenic Arabidopsis showed improved germination rate and root growth under mannitol and combined mannitol plus heat stresses. Altogether, our findings reveal that the MaDREB16 is an important gene of attention to exploit in transgenic breeding to augment tolerance in not only banana against dehydration and its combination with heat stress but also in other crops.
Petrological constraints on magma storage conditions during ongoing post-caldera volcanism at Ioto volcano, Ogasawara, Japan
Authors: Miwa Takahiro , Nagai Masashi , Kozono Tomofumi , Nakada Setsuya , Yasuda Atsushi , Ozawa Taku , Ueda Hideki , Tanada Toshikazu , Fujita Eisuke 
Published: July 2024

Abstract

Active volcanism occurs at post-caldera volcanoes, which are often characterized by rapid crustal uplift due to the development of resurgent domes. Post-caldera volcanism has been attributed to the behavior of volcanic fluids in a magma storage region beneath the caldera. However, few studies have provided petrological constraints on magma storage during ongoing post-caldera volcanism. In this paper, we describe the petrological characteristics of the eruptive products from the 2022 eruption at Ioto volcano, Ogasawara, Japan, which provide a unique opportunity to examine magma storage conditions. The 2022 Ioto magma is characterized by a trachytic composition and contains ~7 vol.% phenocrysts (plagioclase, clinopyroxene, olivine, and magnetite). The clinopyroxene–liquid geothermometer and plagioclase–liquid hygrometer yield a temperature of 970 ± 30°C and water content of 1.4 ± 1.1 wt.% for the Ioto magma. The water content corresponds to a pressure of 25 ± 22 MPa, implying magma is stored at a depth of 1.2 ± 1.0 km beneath the volcano. This depth is consistent with the funnel-shaped magma body at 1–2 km depth inferred from geophysical data. As such, we conclude that the 2022 eruption was sourced from magma stored at ~1.2 km depth. Intrusion of magma through a cone sheet may have contributed to the block-like uplift of Motoyama, which is part of the ongoing post-caldera volcanism at Ioto volcano.
GIS-Based Multi Factor Analysis for Positioning Water Harvesting Sites Integrated with Managed Aquifer Recharge
Authors: Shaban Amin , Hage Mhamad El , Farhat Nasser 
Published: July 2024

Abstract

Runoff loss to the sea and seawater intrusion into coastal aquifers represent a dual hydrologic phenomenon in many coastal regions. In this respect, an integrated management approach must be adopted to mitigate the impact of this geo-environmental problem, through surface water harvesting and recharging (SWHR) it into the beneath rock formations. However, positioning suitable sites, for surface water harvesting where from this water can be artificially/spontaneously recharged, is often a challenge. This study handles this challenge with innovative multi factor analysis using GIS to identify the optimal sites for SWHR. For this purpose, thematic maps were analysed and systematically integrated with data retrieved from satellite images (e.g., Sentinel-2, SRTM, etc.). The obtained geospatial data represent main factors controlling surface water flow regime, infiltration potential and other relevant environmental factors. Being converted to GIS digital files with various levels of impact on SWHR, these factors were together systematically manipulated; and thus 28 sites were identified and hydrologically characterized. The produced SWHR sites' map serves decision makers to take proper actions for water management in coastal zones whether in the investment of surface water or the mitigation of seawater intrusion.
Characterization of a Pyroptosis-Related lncRNA signature to evaluate immune features and predict prognosis in Lower-grade glioma
Authors: Chen Yi , Liu Qiang , Yu Qing , Sui Rui , Shi Ji , Liang Haiyang , Liu Jia , Zhang Xuanming , Xu Huizhe , Piao Haozhe 
Published: July 2024

Abstract

Lower-grade gliomas (LGGs), primarily affecting younger populations, pose a unique challenge in oncological treatment due to their diverse genetic and molecular profiles. Pyroptosis, a specialized form of programmed cell death different from apoptosis, plays a crucial role in cancer pathogenesis by causing cell lysis and inflammation, thereby affecting tumor behavior. This study focuses on the prognostic importance of pyroptosis-related long non-coding RNAs (lncRNAs) in LGGs, aiming to provide new perspectives for individualized therapy. The research involved bioinformatic and statistical analyses of data from The Cancer Genome Atlas (TCGA) and the Chinese Glioma Genome Atlas (CGGA). It includes the collection of RNA-seq expression data from TCGA and CGGA databases, identification of prognostic pyroptosis-related lncRNAs through Pearson correlation and Cox regression analysis, and construction of a Prognostic LncRNA Pyroptosis Score (PLPS) using LASSO regression. The study also encompasses functional enrichment analysis using GO and GSEA, immune characteristics evaluation using various algorithms, and analysis of the genetic landscape in different PLPS subgroups. The study identified 18 pyroptosis-related lncRNAs with significant prognostic value in LGG patients. From these, a PLPS was developed, based on 8 selected lncRNAs, to predict the overall survival of LGG patients. Patients were classified into low-risk and high-risk groups according to the PLPS, allowing an evaluation of their prognoses and clinical molecular features. The study also investigated the immune infiltration status and genomic variations of these patients. The research demonstrated the potential of the identified lncRNAs as biomarkers for personalized treatment strategies in LGG. The findings revealed a complex interaction between pyroptosis, lncRNAs, and tumor biology in LGGs, highlighting the importance of pyroptosis in tumor progression. This study not only contributes significantly to our understanding of LGG pathogenesis and treatment but also opens new pathways for developing targeted therapies based on individual molecular profiles. The results underscore the potential for more effective, personalized treatment approaches in oncology, particularly in the context of LGG.