bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of myeloperoxidase to treat left ventricular dysfunction in non‐ischaemic cardiomyopathy
Authors: Geissen Simon , Braumann Simon , Adler Joana , Nettersheim Felix Sebastian , Mehrkens Dennis , Hof Alexander , Guthoff Henning , von Stein Philipp , Witkowski Sven , Gerdes Norbert , Tellkamp Frederik , Krüger Marcus , Isermann Lea , Trifunovic Aleksandra , Bunck Alexander C. , Mollenhauer Martin , Winkels Holger , Adam Matti , Klinke Anna , Buch Gregor , ten Cate Vincent , Hellmich Martin , Kelm Malte , Rudolph Volker , Wild Philipp S. , Rosenkranz Stephan , Baldus Stephan 
Published: August 2024

AbstractAimsNon‐ischaemic cardiomyopathy (NICMP), an incurable disease terminating in systolic heart failure (heart failure with reduced ejection fraction [HFrEF]), causes immune activation, however anti‐inflammatory treatment strategies so far have failed to alter the course of this disease. Myeloperoxidase (MPO), the principal enzyme in neutrophils, has cytotoxic, pro‐fibrotic and nitric oxide oxidizing effects. Whether MPO inhibition ameliorates the phenotype in NICMP remains elusive.Methods and resultsPrognostic information from MPO was derived from proteomic data of a large human cardiovascular health cohort (n = 3289). In a murine model of NICMP, we studied the mechanisms of MPO in this disease. In a case series, the MPO inhibitor was also evaluated in NICMP patients. Individuals with increased MPO revealed higher long‐term mortality and worsening of heart failure, with impaired prognosis when MPO increased during follow‐up. MPO infusion attenuated left ventricular ejection fraction (LVEF) in mice with NICMP, whereas genetic ablation or inhibition of MPO decreased systemic vascular resistance (SVR, 9.4 ± 0.7 mmHg*min/ml in NICMP vs. 6.7 ± 0.8 mmHg*min/ml in NICMP/Mpo−/−mice, n = 8, p = 0.006, data expressed as mean ± standard error of the mean) and improved left ventricular function (LVEF 30.3 ± 2.2% in NICMP vs. 40.7 ± 1.1% in NICMP/Mpo−/− mice, n = 16, p < 0.0001). Four patients diagnosed with NICMP and treated with an MPO inhibitor over 12 weeks showed increase in LVEF, decline in natriuretic peptides and improved 6‐min walking distance. MPO inhibitor‐related changes in the proteome of NICMP patients predicted reduced mortality when related to the changes in the proteome of the above referenced cardiovascular health cohort.ConclusionsMyeloperoxidase predicts long‐term outcome in HFrEF and its inhibition elicits systemic anti‐inflammatory and vasodilating effects which translate into improved left ventricular function. MPO inhibition deserves further evaluation as a novel, complementary treatment strategy for HFrEF.
Synthesis of Double Benzimidazole‐Fused Quinazolines and Pyrimidines Catalyzed by Recyclable Magnetic Cu‐MOF‐74
Authors: Lee Seong Weon , Dao Pham Duy Quang , Cho Chan Sik 
Published: August 2024

Abstract2‐(2‐Bromoaryl)‐ and 2‐(2‐bromovinyl)benzimidazoles are combined and cyclized with benzimidazoles using a catalytic amount of magnetic Cu‐MOF‐74 (Fe3O4@SiO2@Cu‐MOF‐74) and a base under O2 atmosphere, yielding the corresponding double benzimidazole‐fused quinazolines and pyrimidines. The catalyst can be recovered using a magnetic bar and reused multiple times without significant loss of catalytic activity. The reaction mechanism likely involves the initial formation of a C−N coupled intermediate through nucleophilic aromatic substitution, followed by oxidative cyclization.
Nursing of forearm hematoma after transradial coronary intervention
Authors: Zhi Guangshuo , Lei Mengjie , Qian Shuang , Zhang Chunyan , Li Yachao , Zhao Zhigang , Xue Zengming 
Published: August 2024

AbstractBackgroundComplications such as forearm hematoma after coronary intervention through the radial artery are a common complication.Material and methodsBy observing, describing, and analyzing the pictures taken during clinical diagnosis and consultation, we summarize the prevention, treatment, and nursing of forearm hematoma after percutaneous coronary intervention, to provide reference for the nursing of patients with forearm hematoma.ResultsWe have innovatively summarized the risk classification of forearm hematoma and the three key time points for preventing hematoma.ConclusionComplications such as forearm hematoma after coronary intervention through the radial artery are a common complication. We have innovatively summarized the risk classification of forearm hematoma and the three key time points for preventing hematoma, providing reference for the prevention and management of forearm hematoma in clinical practice. For patients undergoing transradial coronary intervention, the three key time points for preventing hematoma and symptomatic management based the risk classification of forearm hematoma are crucial.
Clinical characteristics, outcomes and persistent symptoms of pregnant women with COVID‐19: A retrospective cohort study
Authors: Ghizzoni Ana Paula Orlandi , Santos André Kulzer , de Braga Raimunda Sinthia Lima , Duz João Vitor Vigne , Bouvier Vitoria Dall’agnol , de Souza Marina Scheffer , Silva Denise Rossato 
Published: August 2024

AbstractObjectiveThe aim of this study was to evaluate the clinical characteristics and outcomes of pregnant women with COVID‐19 and to compare with pregnant women without COVID‐19. In addition, in the subgroup of patients who were symptomatic at the time of diagnosis, the persistence of symptoms was assessed.MethodsThis was a retrospective cohort study. All pregnant women aged ≥18 years, admitted to the maternity ward from March 2020 to September 2023 were included in the study. All patients admitted were routinely screened for SARS‐CoV‐2. Clinical characteristics and outcomes were registered.ResultsDuring the study period, 880 patients met the inclusion and were included in the analysis: 385 were COVID‐19 positive and 495 were COVID‐19 negative. In a multivariate analysis of the outcomes associated with COVID‐19 among pregnant women, hospitalization and the Apgar score at 5 min were independently associated with COVID‐19. Cesarean delivery, preterm birth, Apgar scores at 1 and 5 min <7, and maternal death were more frequent in pregnant women with COVID‐19 admitted to ICU than in those not admitted to ICU. Approximately 30% of patients had persistence of symptoms, for at least 6 months in almost 60%.ConclusionThe findings of the present study suggest that COVID‐19 was associated with increased morbidity and mortality among pregnant women. In addition, pregnant women with SARS‐CoV‐2 infection were at significantly higher risk of adverse perinatal outcomes, especially preterm birth.
GLAN: Global Local Attention Network for Thoracic Disease Classification to Enhance Heart Failure Diagnosis
Authors: Li Dengao , Mu Yujia , Zhao Jumin , Shi Changcheng , Wang Fei 
Published: August 2024

ABSTRACTChest x‐ray (CXR) is an effective method for diagnosing heart failure, and identifying important features such as cardiomegaly, effusion, and edema on patient chest x‐rays is significant for aiding the treatment of heart failure. However, manually identifying a vast amount of CXR data places a huge burden on physicians. Deep learning's progression has led to the utilization of this technology in numerous research aimed at tackling these particular challenges. However, many of these studies utilize global learning methods, where the contribution of each pixel to the classification is considered equal, or they overly focus on small areas of the lesion while neglecting the global context. In response to these issues, we propose the Global Local Attention Network (GLAN), which incorporates an improved attention module on a branched structure. This enables the network to capture small lesion areas while also considering both local and global features. We evaluated the effectiveness of the proposed model by testing it on multiple public datasets and real‐world datasets. Compared to the state‐of‐the‐art methods, our network structure demonstrated greater accuracy and effectiveness in the identification of three key features: cardiomegaly, effusion, and edema. This provides more targeted support for diagnosing and treating heart failure.
Zur Gliederung der Subsektion Oenothera (Sektion Oenothera, Oenothera L., Onagraceae)
Authors: Rostański Krzysztof 
Published: August 2024

ZusammenfassungAuf Grund der in den letzten Jahren publizierten Arbeiten zur Taxonomie und geographischen Verbreitung der Oenotheren, sowohl vom Autor selbst als auch von anderen Bearbeitern, und nach kritischer Revision der Herbarbelege von Oenothera aus verschiedenen Herbarien Europas sowie unter Berücksichtigung der neuesten Anordnung der Oenothera‐Arten und Synonyme innerhalb der Subsektion Euoenothera (Raven, Dietrich & Stubbe 1979) ist eine neue Gliederung der Subsektion Oenothera vorgeschlagen worden.Die folgenden Series sind neu besehrieben worden: Linderia (mit 7 Arten), Devriesia (18 Arton und 5 Bastarde), Oenothera (37 Arten und 15 Bastarde), Stubbia (2 Arten) und Ruggleaia (21 Arten und 3 Bastarde).Nach der Revision der Oenothera‐Belege konnte die genaue Synonymik der 10 in Europa beschriebenen Arten festgestellt werden: Oenothera renneri H. Scholz = Oe. canovirens Steele; Oe. hungarica Borbás = Oe. salicifolia Desf. ex G. Don, non Oe. villosa Thuhberg; Oe. nissensis Rostański = Oe. victorini Gates; Oe. lipsiensusu Rostański et Gutte = Oe. deflexa Gates; Oe. turoviensis Rostański = Oe. royfraseri Gates; Oe. chicaginensis De Vries ex Renner = Oe. pyenocarpa Atkinson et Bartlett; Oe. cambrica Rostański = Oe. novae‐scotiae Gates; Oc. erateinensis Linder et Jean = Oe. perangusta Gates = Oe. strigosa (Rydb.) Mackenzie et Bush sensu Rydberg, non auct.; Oe. silesiaca Renner = Oe. subterminalis Gates; Oe. rubicuspis Renner ex Rostański = Oe. angustissima Gates; ebenso von der amerikanischen Oe. atrovirens Shull et Bartlett apud auct. europ. = Oe. cruciata Nuttal ex G. Bon.
Untersuchungen zum Wasserhaushalt in der Halbwüstenvegetation des Gobi‐Altai (MVR)1)
Authors: Helmecke K. , Bumžaa D. 
Published: August 2024

ZusammenfassungAm Südufer des Orog‐nuur wurden im Zusammenhang mit geobotanischen und mikroklimatischen Arbeiten auch Untersuchungen zum Wasserhaushalt der Halbwüstenvegetation durchgeführt. Dabei erfolgte die Bestimmung der Bodenfeuchtigkeit, der Saugspannung und des potentiellen osmotischen Druckes (π*) der Pflanzen. Am Beispiel der südlichen Beifläche des Orog‐nuur konnte die gute Anwendbarkeit der Bestimmung von π* zur Beurteilung des Wasserhaushaltes am Standort aufgezeigt werden.
Evaluating the Feasibility of Short Dental Implants as Alternatives to Long Dental Implants in Mandibular Bone: A Finite Element Study
Authors: Deshmukh Prathamesh , Dhatrak Pankaj 
Published: August 2024

ABSTRACTThis study uses finite element analysis to investigate the potential application of shorter dental implants as a substitute for longer implants in the lower jaw (mandible). FEA allows the evaluation of the stress patterns around the implant‐bone interface, a critical factor for successful osseointegration. Ten models were generated, encompassing five long (L1‐L5) and five short implant models (S1‐S5) with variations in diameter and length. Hypermesh software was utilized to meticulously prepare the FEA models, ensuring accurate mesh generation. The FEA simulations were conducted under four distinct loading scenarios (100 N occlusal load, 40 N lateral load, 100 N oblique at 30°, and 100 N oblique at 45°) to realistically mimic the forces exerted during biting, using an ABAQUS CAE solver. The results revealed that the von Mises stress generated within the short implant models was demonstrably lower compared to their long implants. Additionally, a significant drop in stress was observed with increasing the diameter of the short implants, to a certain diameter range. These findings suggest the potential for successful substitution of long implant model L4 with short implant model S4 due to the demonstrably lower stress values achieved. Furthermore, the data indicates the possibility of utilizing short implant models S3 and S5 as alternatives to long implant models L3 and L5, respectively. These observations hold significant promise for evaluating the feasibility of replacing long implants with shorter variants, potentially leading to a reduction in implant‐related failures.
Ab initio electronic absorption spectra of para‐nitroaniline in different solvents: Intramolecular charge transfer effects
Authors: Máximo‐Canadas Matheus , Modesto‐Costa Lucas , Borges Itamar 
Published: August 2024

AbstractIntramolecular charge transfer (ICT) effects of para‐nitroaniline (pNA) in eight solvents (cyclohexane, toluene, acetic acid, dichloroethane, acetone, acetonitrile, dimethylsulfoxide, and water) are investigated extensively. The second‐order algebraic diagrammatic construction, ADC(2), ab initio wave function is employed with the COSMO implicit and discrete multiscale solvation methods. We found a decreasing amine group torsion angle with increased solvent polarity and a linear correlation between the polarity and ADC(2) transition energies. The first absorption band involves π → π* transitions with ICT from the amine and the benzene ring to the nitro group, increased by 4%–11% for different solvation models of water compared to the vacuum. A second band of pNA is characterized for the first time. This band is primarily a local excitation on the nitro group, including some ICT from the amine group to the benzene ring that decreases with the solvent polarity. For cyclohexane, the COSMO implicit solvent model shows the best agreement with the experiment, while the explicit model has the best agreement for water.
Preliminary Research of Radiolabeled Atezolizumab for the Noninvasive Evaluation of TNBC PD‐L1 Expression In Vivo
Authors: He Shuhua , Jia Lina , Zheng Xiaobei , Wang Yang , Liu Yuxia , Zhang Lan 
Published: August 2024

ABSTRACTProgrammed death‐ligand 1 (PD‐L1) expression is related to the efficacy and prognosis in triple‐negative breast cancer. This study employed an indirect labeling method to synthesize [125I]PI‐Atezolizumab. The in vitro stability of [125I]PI‐Atezolizumab was assessed through incubation in phosphate buffered saline and fetal bovine serum, revealing sustained stability. Specific binding of [125I]PI‐Atezolizumab to MDA‐MB‐231 cells expressing humanized PD‐L1 was assessed through in vitro incubation, yielding a Kd value comparable to that of Atezolizumab. This suggests that the labeling process did not compromise the affinity of the Atezolizumab to PD‐L1. Subsequently, pharmacokinetic studies were conducted in normal mice and biodistribution experiments in tumor‐bearing mice. A comparison of the biodistribution results between [125I]PI‐Atezolizumab and 125I‐labeled Atezolizumab indicated better in vivo stability for the former. Single photon emission computed tomography (SPECT)/CT imaging further confirmed the targeted specificity of [125I]PI‐Atezolizumab for PD‐L1 in MDA‐MB‐231 xenografts, which were validated by immunohistochemistry staining. This research underscores the utility of [125I]PI‐Atezolizumab, prepared via indirect labeling, for monitoring PD‐L1 in triple‐negative breast cancer models.
Simultaneous Increase of Mean Susceptibility and Mean Kurtosis in the Substantia Nigra as an MRI Neuroimaging Biomarker for Early‐Stage Parkinson's Disease: A Systematic Review and Meta‐Analysis
Authors: Mohammadi Sana , Ghaderi Sadegh , Mohammadi Hossein , Fatehi Farzad 
Published: August 2024

BackgroundParkinson's disease (PD) is the second most common neurodegenerative disorder. Early detection is crucial for treatment and slowing disease progression.HypothesisSimultaneous alterations in mean susceptibility (MS) from quantitative susceptibility mapping (QSM) and mean kurtosis (MK) from diffusion kurtosis imaging (DKI) can serve as reliable neuroimaging biomarkers for early‐stage PD (ESPD) in the basal ganglia nuclei, including the substantia nigra (SN), putamen (PUT), globus pallidus (GP), and caudate nucleus (CN).Study TypeSystematic review and meta‐analysis.PopulationOne hundred eleven patients diagnosed with ESPD and 81 healthy controls (HCs) were included from four studies that utilized both QSM and DKI in both subject groups.Field Strength/SequenceThree‐dimensional multi‐echo gradient echo sequence for QSM and spin echo planar imaging sequence for DKI at 3 Tesla.AssessmentA systematic review and meta‐analysis using PRISMA guidelines searched PubMed, Web of Science, and Scopus.Statistical TestsRandom‐effects model, standardized mean difference (SMD) to compare MS and MK between ESPD patients and HCs, I2 statistic for heterogeneity, Newcastle‐Ottawa Scale (NOS) for risk of bias, and Egger's test for publication bias. A P‐value <0.05 was considered significant.ResultsMS values were significantly higher in SN (SMD 0.72, 95% CI 0.31 to 1.12), PUT (SMD 0.68, 95% CI 0.29 to 1.07), and GP (SMD 0.53, 95% CI 0.19 to 0.87) in ESPD patients compared to HCs. CN did not show a significant difference in MS values (P = 0.15). MK values were significantly higher only in SN (SMD = 0.72, 95% CI 0.16 to 1.27). MK values were not significantly different in PUT (P = 1.00), GP (P = 0.97), and CN (P = 0.59). Studies had high quality (NOS 7‐8) and no publication bias (P = 0.967).Data ConclusionSimultaneous use of MS and MK may be useful as an early neuroimaging biomarker for ESPD detection and its differentiation from HCs, with significant differences observed in the SN.Evidence Level2Technical EfficacyStage 2
Despite the haters: The immense promise and progress of diversity, equity, and inclusion initiatives
Authors: Nittrouer Christine L. , Arena David , Silver Elisabeth R. , Avery Derek R. , Hebl Mikki R. 
Published: August 2024

SummaryIn the current paper, we discuss the positive impact of diversity, equity, and inclusion (DEI) initiatives in our workplaces, including the historical movements that led to their inception as well as the reactions that have resulted in forms of resistance and backlash. Although there may be risks inherent in engaging in social justice work within organizations, we summarize the large body of empirical work documenting the immense benefits of choosing to do so. We argue that the promise of DEI initiatives is evidenced in the research‐based findings demonstrating the effectiveness of those initiatives that have emerged over time (e.g., including both representation and inclusion focused initiatives). The progress made by several DEI initiatives that are still being fully explored is discussed, and we maintain their effectiveness within certain contexts provided the use of current empirical evidence. We conclude by suggesting the evolving science behind DEI initiatives is exactly what we would expect when responsibly employing the scientific method and, that by reviewing the data, it is clear that the long‐term benefits provided by DEI initiatives far outweigh any short‐term risks.
Combinations of approach and avoidance crafting matter: Linking job crafting profiles with proactive personality, autonomy, work engagement, and performance
Authors: Zhang Fangfang , Tims Maria , Parker Sharon K. 
Published: August 2024

SummaryTraditional variable‐centered job crafting research typically examines individual job crafting behaviors in isolation. This study builds upon existing person‐centered job crafting research, aiming to further validate job crafting profiles based on the job demands‐resources model. By testing profile similarity across different samples and time points, we identify three consistent job crafting profiles: proactive crafters, characterized by a high use of approach crafting and a moderate use of avoidance crafting; active crafters, who exhibit an average level of all job crafting strategies; and reactive crafters, marked by a low use of approach crafting strategies but a relatively high use of avoidance crafting. As theorized, the proactive crafters profile emerged as the most desirable, displaying the highest levels of self‐reported work engagement, task performance, and organizational citizenship behavior. This finding underscores that avoidance crafting becomes less detrimental when used alongside approach crafting. Moreover, our study reveals that proactive personality and job autonomy significantly increase the likelihood of employees being proactive crafters, offering empirical support for the notion that avoidance crafting can be an integral part of a proactive goal when combined with approach crafting.
Are human activities or climate changes the main causes of soil erosion in the South African drylands?: A palaeo‐perspective from three sites in the interior
Authors: Lyons Richard , Tooth Stephen , Duller Geoff A. T. , McCarthy Terence 
Published: August 2024

ABSTRACTSoil erosion across South Africa's drylands occurs widely in the form of gullies and badlands (locally termed dongas) that have developed in colluvium and in valley fills along incised rivers. This erosion has commonly been attributed to land mismanagement, particularly since European settlement, but natural factors such as soil properties, local base level fall and climate change have also been invoked. To disentangle human and natural factors, we use optically stimulated luminescence (OSL) dating, supported by documentary and archaeological evidence, to constrain the timing and causes of donga formation at three widely spaced sites across interior South Africa. At all three sites, the exposed stratigraphy indicates that hillslopes and floodplains underwent net sediment accumulation during most of the late Quaternary, and that present‐day deep erosion is of a magnitude unprecedented probably within at least the past 100 ka. OSL ages indicate that the onset of erosion at each site significantly pre‐dates European incursion and instead was broadly coincident with abrupt climatic changes that occurred during the Medieval Climatic Anomaly (MCA, ~ad 900–1300) and Little Ice Age (LIA, ~
ad 1300–1800). Based on correlation with palaeoclimate proxy records, we propose that erosion was triggered by abrupt hydroclimatic oscillations during the MCA, and continued during the LIA in response to climate‐driven, large floods. At these sites, soil type and local base level falls exert secondary controls on the specific locations, processes, rates and depths of erosion. In other areas of South Africa, clear links between land mismanagement and soil erosion have been demonstrated, but for sites where detailed investigations have yet to be undertaken, these findings challenge an often default assumption that soil erosion is necessarily attributable to human factors. Our findings have significant implications for soil erosion control strategies and assessment of South African dryland landscape response to future climate changes.