bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Practitioners’ Guide to Gravity Models of International Migration
Authors: Beine Michel , Bertoli Simone , Fernández‐Huertas Moraga Jesús 
Published: March 2015

AbstractThe use of bilateral data for the analysis of international migration is at the same time a blessing and a curse. It is a blessing because the dyadic dimension of the data allows researchers to address a number of previously unanswered questions, but it is also a curse for the various analytical challenges it gives rise to. This paper presents the theoretical foundations of the estimation of gravity models of international migration, and the main difficulties that have to be tackled in the econometric analysis, such as the nature of migration data, how to account for multilateral resistance to migration or endogeneity. We also review some empirical evidence that has considered these issues.
Migration Policy, African Population Growth and Global Inequality
Authors: Mountford Andrew , Rapoport Hillel 
Published: March 2015

AbstractAccording to recent UN projections, more than 50 per cent of the growth in world population over the next half century will be due to population growth in Africa. Given this, any policy that influences African demography will have a significant impact on the world distribution of income. In this study, we discuss the potential for migration policies to affect fertility and education decisions, and hence, population growth in Africa. We present the results from different scenarios for more or less restrictive/selective migration policies and derive their implications for the evolution of world inequality.
Achromatopsia in three sibling Labrador Retrievers in the UK
Authors: Dixon Christopher J. 
Published: March 2015

AbstractAchromatopsia was identified in three Labrador Retriever littermates. The dogs demonstrated day blindness, negotiating obstacles under low‐light conditions, but apparently blind when outdoors. One of the dogs presented with immature bilateral diffuse posterior cortical cataracts and clinical signs of day blindness became apparent following cataract extraction surgery. Electroretinography demonstrated an absence of a cone photoreceptor response to a bright stimulus and a flicker response of 30 Hz in all three dogs. No fundic lesions have been apparent ophthalmoscopically in any of the dogs as the initial presentation of each case. No abnormalities were detected with DNA screening for known mutations of the CNGB3 gene in any of the dogs.
Passive reporting greatly underestimates the rate of transfusion‐associated circulatory overload after platelet transfusion
Authors: Raval J. S. , Mazepa M. A. , Russell S. L. , Immel C. C. , Whinna H. C. , Park Y. A. 
Published: March 2015

BackgroundTransfusion‐associated circulatory overload (TACO) is the second leading cause of reported transfusion‐related fatalities in the United States. While its occurrence has been previously investigated after red cell and plasma transfusion, no data are available regarding its association with platelet transfusion. Our goal was to determine the rate of platelet‐associated TACO at our university medical centre.Study Design and MethodsThis study had retrospective and prospective analyses. The 13‐year retrospective analysis served to determine the historical rate of platelet‐associated TACO by passive reporting. The 30‐day prospective analysis included active surveillance of all non‐emergently issued and non‐operative platelet recipients ≥16 years old with no transfusions in the previous 6 h determined by analysis of blood bank product issue records. Data collected included demographics, vital signs pre‐ and posttransfusion, fluid balances, supplemental oxygen use, reports of dyspnoea, and infusion rates. For the prospective analysis, all variables were collected within 24 h of transfusion from the medical record and, when necessary, interviews with care providers and/or patients.ResultsIn the retrospective analysis, 366 reactions were reported, of which 6 (1·6%) were TACO. The historical rate of TACO was 1:5997 transfused platelet units. During the prospective analysis, 225 eligible patients received a total of 334 units of platelets. The average platelet transfusion volume was 261 ± 26 ml, and the average infusion rate was 391 ± 198 ml/h. Two unreported TACO reactions were discovered and characterized by new‐onset hypertension, crackles on lung auscultation, dyspnoea, hypoxia and supplemental oxygen requirements which resolved completely with diuresis. The rate of TACO during this prospective analysis was 1:167 transfused platelet units.ConclusionPlatelet‐associated TACO is greatly underestimated by passive reporting in the adult patient population.
The effects of an overnight holding of whole blood at room temperature on haemoglobin modification and in vitro markers of red blood cell aging
Authors: Eckstein M. , Zimmermann R. , Roth T. , Hauck‐Dlimi B. , Strasser E. F. , Xiang W. 
Published: March 2015

BackgroundSome effects of the red blood cell (RBC) storage lesion are well documented whereas others are not. Whether a period of room temperature hold (RTH) during RBC production enhances the RBC storage lesion has remained controversial. In this study, we compared whole blood (WB)‐derived RBCs produced after 24‐h RTH with rapidly cooled (RC) RBCs and tested them for classical metabolic markers and signs of oxidative damage.Study design and methodsSAGM‐RBCs were prepared from mixed and split pairs (n = 12) of WB units. RBCs prepared after a 24‐h period of RTH on day+1 after collection (RTH‐RBCs) were compared with RC‐RBCs. All RBCs were stored at 4°C for 42 days with assay of in vitro variables on days+1, +15, +22, +29 and +42. The study examined standard quality parameters, glutathione, catalase and superoxide dismutase (SOD) activities, and indicative markers of oxidative cell damage including post‐translational haemoglobin modification, malondialdehyde (MDA), and phosphatidylserine expression.ResultsRTH‐RBCs exhibited decreased levels of potassium (1·98 ± 0·26 vs. 5·23 ± 0·65 mmol/l) and of 2,3‐diphosphoglycerate (2,3‐DPG) on day+1 compared with RC‐RBCs. Haemolysis rate on day+42 was higher in RTH‐RBCs than in RC‐RBCs (0·52 ± 0·13 vs. 0·37 ± 0·12%). The phosphatidylserine expression amounted to 0·25 ± 0·20% in RTH‐RBCs and 0·07 ± 0·12% in RC‐RBCs. Haemoglobin modification was not different between both RBC groups. RTH‐RBCs showed slightly higher MDA concentration on days +29 and +42.ConclusionsRC‐RBCs and RTH‐RBCs show only small differences of classical in vitro parameters and no relevant differences in antioxidative metabolism and oxidative haemoglobin modification. These findings do not explain the loss observed in in vivo survival studies with RBCs.
Improving red cell transfusion in the elective surgical setting: an improvement collaborative with evaluation
Authors: Harrison B. T. , Chen J. , Der Vartanian C. , Isbister J. , Tridgell P. , Hughes C. F. 
Published: March 2015

Background & ObjectivesSignificant research conducted in New South Wales (NSW) hospitals’ indicated that about 30% of red cell transfusions in stable adult patients was inappropriate. Of the total Australian government blood product budget in 2009–2010 (i.e. $878·8 million dollars) was spent on fresh blood products and plasma collection. The Clinical Excellence Commission (CEC) launched a systematic intervention called Blood Watch (BW) aiming to reduce inappropriate red cell transfusions in all NSW hospitals. An evaluation of BW was undertaken to measure the effectiveness of the programme and to estimate the associated potential cost‐saving.Materials & MethodsThrough the deterministic linkage of the four population‐based administrative databases, three outcome indicators and four process indicators were developed. The analyses were of five elective surgical groups as they were the focus of the interventions. Three‐level logistic regression and three‐level linear regression were used to explore the time trend of the study process and outcome indicators. Modelling of the possible avoided red cell transfusions was also undertaken using a quadratic regression technique.ResultsOverall, there was a 27·4% reduction of the blood usage after the introduction of the BW programme and the reductions were consistent across five elective surgical groups. Such a reduction was associated with annual cost‐savings of over $8·5 million.ConclusionsThe BW programme which was based on collaborative improvement methods and implemented at scale led to significant reduction of blood usage, consistently across five elective surgical groups and significant cost‐saving.
Comparison of the cryoprotective solutions based on human albumin vs. autologous plasma: its effect on cell recovery, clonogenic potential of peripheral blood hematopoietic progenitor cells and engraftment after autologous transplantation
Authors: Smagur A. , Mitrus I. , Ciomber A. , Panczyniak K. , Fidyk W. , Sadus‐Wojciechowska M. , Holowiecki J. , Giebel S. 
Published: March 2015

Background and ObjectivesCryopreservation of peripheral blood hematopoietic progenitor/stem cells (PBPCs) requires the addition of cryoprotectant such as DMSO, often prediluted using human serum albumin solution (HSAS). The goal of our study was to verify whether the HSAS may be replaced by autologous plasma (AP) without negative impact on PBPCs quality and engraftment. AP usage is less expensive and allows performing cell preparation in a ‘closed system’, and hence to reduce the risk of product contamination.Materials and MethodsPeripheral blood progenitor cells from 18 patients were divided into two aliquots (500 μl) placed in separate vials, each containing 7·5% DMSO prediluted with 5% HSAS or AP. Post‐thaw cell recovery and clonogenic potential was evaluated. During clinical part of the study, the impact of both cryoprotective solution on hematopoietic engraftment was evaluated in two cohorts (n = 26) matched for diagnosis, age and the number of transplanted CD34+ cells.ResultsThe median recovery of nucleated cells and the number of colony‐forming units did not differ between tested cryoprotective mixtures. For AP mixture, neither total protein nor albumin concentration of plasma correlated with cell recovery and clonogenic potential of the PBPCs after cryopreservation. In clinical evaluation, the median time to leucocyte recovery and reconstitution of neutrophils was comparable in both groups: 10 days. We did not observe either significant difference with regard to the time of platelet recovery (median: 15 days for AP vs. 16 for HSAS; P = 0·79).ConclusionsHSA in cryoprotective mixture may be replaced by AP without negative impact on cell recovery, clonogenic potential or engraftment.
Persistent aggregates in apheresis platelet concentrates
Authors: Feys H. B. , Coene J. , Devloo R. , Van Aelst B. , Pottel H. , Vandekerckhove P. , Compernolle V. 
Published: March 2015

BackgroundAggregates often appear during apheresis. Sometimes, these persist throughout storage, causing product wastage. This study assessed product quality of apheresis concentrates containing persistent aggregates (PA) and aimed to identify the factors that contribute to their formation.MethodsDonation (n = 180) and platelet indices (n ≥ 10) from apheresis concentrates with PA were compared with aggregate‐free products.ResultsThe proportion of donors with at least one previous PA donation was twofold higher in the PA group (P < 0·0001) indicating a donor dependence. Significantly higher donor whole blood platelet counts (286 ± 50 vs. 266 ± 49 × 103/μl, P < 0·0001) and higher apheresis yields (6·0 ± 1·6 vs. 5·4 ± 1·5 × 1011, P < 0·0001) were noted in the PA group. Haematocrit was also slightly higher, but age, gender and body mass were similar. The pH of PA products on day six postdonation was significantly lower (P < 0·001), in line with higher lactic acid concentrations. Flow cytometry showed no differences in GPIbα levels or phosphatidylserine exposure. However, there was slightly more integrin activation as well as increased degranulation measured by P‐selectin expression. Cytokine concentrations were also significantly higher in PA concentrates. Aggregation was normal in response to SFLLRN peptide and collagen stimulation, but agglutination at low‐dose ristocetin was significantly higher (P = 0.01) in PA products. Finally, PA were disintegrated by plasmin‐mediated thrombolysis but not by integrin αIIbβ3 inhibition.ConclusionProducts with PA have acceptable quality parameters, but additional functional studies are warranted. Furthermore, PA are more likely to recur in certain donors who have higher platelet counts.
Draft Genome Sequence of a Taxonomically Unique Acinetobacter Clinical Strain with Proteolytic and Hemolytic Activities
Authors: Traglia German Matías , Almuzara Marisa , Barberis Claudia , Montaña Sabrina , Schramm Sareda T. J. , Enriquez Brandi , Mussi María Alejandra , Vay Carlos , Iriarte Andres , Ramírez María Soledad 
Published: March 2015

ABSTRACT

Acinetobacter sp. strain A47, which has been recovered from several soft tissue samples from a patient undergoing reconstructive surgery due to a traumatic amputation, was categorized as a taxonomically unique bacterial strain. The molecular analysis based on three housekeeping protein-coding genes (16S rRNA,
rpoB
, and
gyrB
) showed that strain A47 does not belong to any of the hitherto known taxa and may represent a previously undescribed Acinetobacter species.
Genome Sequence of Clostridium acetobutylicum GXAS18-1, a Novel Biobutanol Production Strain
Authors: Mo Xinchun , Pei Jianxin , Guo Yuan , Lin Lihua , Peng Lixin , Kou Chan , Fan Danmin , Pang Hao 
Published: March 2015

ABSTRACT

Clostridium acetobutylicum
is an organism involved in the production of acetone and butanol by traditional acetone-butanol-ethanol fermentation (ABE). We report the draft genome sequence of
C. acetobutylicum
strain GXAS18-1, which can produce ABE directly from cassava flour
.
Genome Sequence of Pseudomonas azelaica Strain Aramco J
Authors: El-Said Mohamed Magdy , García José L. , Martínez Igor , del Cerro Carlos , Nogales Juan , Díaz Eduardo 
Published: March 2015

ABSTRACT
We report here the draft genome sequence of Pseudomonas azelaica strain Aramco J (7.3 Mbp; GC content, 61.9%), one of the few bacteria that can completely mineralize different hydroxybiphenyls, e.g., 2-hydroxybiphenyl, 2,2′-dihydroxybiphenyl, and 3-hydroxybiphenyl. The findings obtained from its genome annotation suggest that this strain becomes a useful biocatalyst for aromatic bioconversions.
Draft Genome Sequence of Exopolysaccharide-Producing Cyanobacterium Aphanocapsa montana BDHKU 210001
Authors: Bhattacharyya Sourav , Chandrababunaidu Mathu Malar , Sen Deeya , Panda Arijit , Ghorai Arpita , Bhan Sushma , Sanghi Neha , Tripathy Sucheta 
Published: March 2015

ABSTRACT
We report for the first time the draft genome sequence of Aphanocapsa montana BDHKU 210001, a halotolerant cyanobacterium isolated from India. This is a marine exopolysaccharide (EPS)-producing cyanobacterium. The genome of this species is assembled into 11.50 million bases, with 296 scaffolds carrying approximately 7,296 protein-coding genes.
Complete Genome Sequences of One Human Respiratory Syncytial Antigenic Group A Virus from China and Its Four Mouse-Adapted Isolates
Authors: Zhang Ke , He Jie , Li Cun , Bose Michael E. , Henrickson Kelly J. , Zhou Jie , Zheng Bo-Jian 
Published: March 2015

ABSTRACT
In this study, one human respiratory syncytial antigenic group A virus (HRSV-A-GZ08-0) and its four BALB/c mouse-adapted isolates were sequenced and elucidated. Nineteen nucleotides were mutated between HRSV-A-GZ08-0 and the four mouse-adapted isolates.
Draft Genome Sequence of Cyanobacterium
Hassallia byssoidea
Strain VB512170, Isolated from Monuments in India
Authors: Singh Deeksha , Chandrababunaidu Mathu Malar , Panda Arijit , Sen Diya , Bhattacharyya Sourav , Adhikary Siba Prasad , Tripathy Sucheta 
Published: March 2015

ABSTRACT
The draft genome assembly of Hassallia byssoidea strain VB512170 with a genome size of ~13 Mb and 10,183 protein-coding genes in 62 scaffolds is reported here for the first time. This is a terrestrial hydrophobic cyanobacterium isolated from monuments in India. We report several copies of luciferase and antibiotic genes in this organism.
Draft Genome Sequence of Filamentous Marine Cyanobacterium Lyngbya confervoides Strain BDU141951
Authors: Chandrababunaidu Mathu Malar , Sen Diya , Tripathy Sucheta 
Published: March 2015

ABSTRACT
Lyngbya confervoides strain BDU141951 is a fast-growing, unicellular, marine, nonheterocystous cyanobacterium forming long unbranched filaments inside sheaths. Here, we report the draft genome assembly of Lyngbya confervoides BDU141951 for the first time. The genome size is 8,799,693 bp and has 6,093 putative protein-coding genes assembled into 298 scaffolds.
Draft Genome Sequence of Aeromonas caviae Strain L12, a Quorum-Sensing Strain Isolated from a Freshwater Lake in Malaysia
Authors: Chan Kok-Gan , Chin Pui-San , Tee Kok Keng , Chang Chien-Yi , Yin Wai-Fong , Sheng Kit-Yeng 
Published: March 2015

ABSTRACT

Here, we present the draft genome sequence of
Aeromonas caviae
strain L12, which shows quorum-sensing activity. The availability of this genome sequence is important to the research of the quorum-sensing regulatory system in this isolate.
Draft Genome Sequence of Streptococcus equinus (Streptococcus bovis) HC5, a Lantibiotic Producer from the Bovine Rumen
Authors: Azevedo Analice C. , Bento Cláudia B. P. , Ruiz Jeronimo C. , Queiroz Marisa V. , Mantovani Hilário C. 
Published: March 2015

ABSTRACT

Streptococcus equi
nus

(
Streptococcus bovis
) HC5 is a bacteriocinogenic lactic acid bacterium with simple growth requirements. The draft genome sequence of

S. equi
nus

HC5 consists of 1,846,241 bp, with a G+C content of 37.04%.
In silico
analysis indicated that

S. equi
nus

HC5 might be useful to control bacteria that are detrimental to livestock animals.
MDSC and TGFβ Are Required for Facilitation of Tumor Growth in the Lungs of Mice Exposed to Carbon Nanotubes
Authors: Shvedova Anna A. , Kisin Elena R. , Yanamala Naveena , Tkach Alexey V. , Gutkin Dmitriy W. , Star Alexander , Shurin Galina V. , Kagan Valerian E. , Shurin Michael R. 
Published: March 2015

Abstract
During the last decades, changes have been observed in the frequency of different histologic subtypes of lung cancer, one of the most common causes of morbidity and mortality, with a declining proportion of squamous cell carcinomas and an increasing proportion of adenocarcinomas, particularly in developed countries. This suggests the emergence of new etiologic factors and mechanisms, including those defining the lung microenvironment, promoting tumor growth. Assuming that the lung is the main portal of entry for broadly used nanomaterials and their established proinflammatory propensities, we hypothesized that nanomaterials may contribute to changes facilitating tumor growth. Here, we report that an acute exposure to single-walled carbon nanotubes (SWCNT) induces recruitment and accumulation of lung-associated myeloid-derived suppressor cells (MDSC) and MDSC-derived production of TGFβ, resulting in upregulated tumor burden in the lung. The production of TGFβ by MDSC requires their interaction with both SWCNT and tumor cells. We conclude that pulmonary exposure to SWCNT favors the formation of a niche that supports ingrowth of lung carcinoma in vivo via activation of TGFβ production by SWCNT-attracted and -presensitized MDSC. Cancer Res; 75(8); 1615–23. ©2015 AACR.
The c-Met Tyrosine Kinase Inhibitor JNJ-38877605 Causes Renal Toxicity through Species-Specific Insoluble Metabolite Formation
Authors: Lolkema Martijn P. , Bohets Hilde H. , Arkenau Hendrik-Tobias , Lampo Ann , Barale Erio , de Jonge Maja J.A. , van Doorn Leni , Hellemans Peter , de Bono Johann S. , Eskens Ferry A.L.M. 
Published: March 2015

Abstract
Purpose: The receptor tyrosine kinase c-Met plays an important role in tumorigenesis and is a novel target for anticancer treatment. This phase I, first-in-human trial, explored safety, pharmacokinetics, pharmacodynamics, and initial antitumor activity of JNJ-38877605, a potent and selective c-Met inhibitor.
Experimental Design: We performed a phase I dose-escalation study according to the standard 3+3 design.
Results: Even at subtherapeutic doses, mild though recurrent renal toxicity was observed in virtually all patients. Renal toxicity had not been observed in preclinical studies in rats and dogs. Additional preclinical studies pointed toward the rabbit as a suitable toxicology model, as the formation of the M10 metabolite of JNJ-38877605 specifically occurred in rabbits and humans. Additional toxicology studies in rabbits clearly demonstrated that JNJ-38877605 induced species-specific renal toxicity. Histopathological evaluation in rabbits revealed renal crystal formation with degenerative and inflammatory changes. Identification of the components of these renal crystals revealed M1/3 and M5/6 metabolites. Accordingly, it was found that humans and rabbits showed significantly increased systemic exposure to these metabolites relative to other species. These main culprit insoluble metabolites were generated by aldehyde oxidase activity. Alternative dosing schedules of JNJ-3877605 and concomitant probenecid administration in rabbits failed to prevent renal toxicity at dose levels that could be pharmacologically active.
Conclusions: Combined clinical and correlative preclinical studies suggest that renal toxicity of JNJ-38877605 is caused by the formation of species-specific insoluble metabolites. These observations preclude further clinical development of JNJ-38877605. Clin Cancer Res; 21(10); 2297–304. ©2015 AACR.
A Formação do Laço social na TV e em sites de redes sociais: as hashtags Saramandaia e Donaredonda no processo de conversação em rede
Authors: Bressan Junior Mario Abel , Finger Cristiane Costa 
Published: March 2015

<p>O objetivo desta pesquisa é analisar a configuração do laço social e do processo de conversação em <em>sites</em> de redes sociais, por meio da utilização das #saramandaia e #donaredonda no <em>twitter</em>. Foram analisadas as #saramandaia, postadas nos dias 27 e 28 de setembro de 2013 e #donaredonda, postadas de 05 de novembro a 05 de dezembro de 2013. Pode-se então deduzir que assim como na televisão as <em>hashtags</em> analisadas formam um laço social, por constituírem uma conversão em rede. </p>
Mediações entre o cinema e a dança: Territórios em questão
Authors: Duarte Carolina Natal 
Published: March 2015

<p>Esse texto pretende abordar e evidenciar as múltiplas formas de se pensar o diálogo entre o cinema e a dança, através do corpo e do movimento. Assim, compôs-se um panorama com algumas obras do cinema, que podem ser vistas aliadas à perspectiva da dança e vice-versa, ou diferentes expressões que foram revisitadas e se transformaram em estéticas audiovisuais, compondo espaços de experimentos artísticos-poéticos do cinema- (e da) dança.</p><p> </p>