bluuebunny/crossref_metadata_2025_split huggingface dataset:
La théomania comique de Valère Novarina
Authors: Ramat Christine 
Published: February 2015

L’œuvre de Novarina est étrangement spirituelle. Elle exacerbe une dimension théologique, érige la parole au rang d’un mystère incompréhensible, mais dans un singulier mélange de mystique et d’idiotie, de parodie biblique aussi bien que médiatique. Comment interpréter cette théomania bouffonne ? Novarina est-il le prophète d’un christianisme comique ou l’apôtre facétieux d’une a-théologie iconoclaste ? Il s’agira d’explorer ici les voies dramaturgiques d’une spiritualité comique.
Le rituel de la (s)cène dans quelques pièces de Valère Novarina
Authors: Allen Leigh 
Published: February 2015

À partir de trois scènes de cènes dans trois pièces rapprochées de Valère Novarina, cet article s’interroge sur le rapport que Novarina établit entre la Cène de la Bible et la scène du théâtre. Dans ses allusions à la Cène biblique, Novarina substitue au Christ la parole comme source de vie. Les acteurs s’animent en « mangeant » les mots et ce repas vient représenter l’acte de théâtre lui-même. Comme dans la Bible, la cène devient chez Novarina une partie intégrée d’une histoire plus grande, une histoire du pouvoir transformatif et créatif de la parole humaine.
La mise en scène de l'état de grâce dans le théâtre de Valère Novarina
Authors: Garcin-Marrou Flore 
Published: February 2015

N’y a-t-il pas un paradoxe à associer l’état de grâce et l’idée d’une mise en scène ? L’état de grâce n’arrive sans aucune sollicitation de celui qui la reçoit. Néanmoins, l’acteur sur scène peut s’y disposer. Grand lecteur des mystiques, Valère Novarina propose une dramatisation de l’état de grâce singulière, questionnant à la fois la théologie, l’événement théâtral et le jeu de l’acteur.
Artovarina : un théâtre résurrectionnel
Authors: Grossman Évelyne 
Published: February 2015

La rencontre Novarina/Artaud eut lieu plus d’une fois. On ne racontera pas ici une histoire de famille, d’influence ou de filiation, mais une commune inquiétude – une interrogation partagée de l’inhumanité de la langue. Du coup de dés mallarméen aux anthropoglyphes-hiéroglyphes levés sur la page, se décèle une commune traversée de l’inhumain : Artovarina , corps-théâtre toujours en voie de surrection.
De l'intérêt de la régression multiniveau en politique comparée
Authors: Bol Damien 
Published: February 2015

La régression est la technique d’analyse de données la plus répandue en science politique. Elle permet de mesurer l’effet net d’une variable explicative sur une variable expliquée en contrôlant l’effet perturbateur d’autres variables. Une de ses sous-techniques dite ‘régression multi-niveau’ est destinée à l’analyse de bases de données regroupant des informations issues de différents pays, comme par exemple les réponses à des sondages réalisés sur différents échantillons de populations européennes ou les résultats de plusieurs élections de par le globe. La régression multi-niveau est toutefois sous-exploitée dans la politique comparée francophone. La plupart des analyses quantitatives publiées dans les meilleures revues de la discipline se bornent en effet à réaliser les mêmes régressions en parallèle dans différents pays et à comparer leurs résultats. Cet article présente deux types spécifiques de régression multi-niveau : la régression à effets fixes et la régression à effets aléatoires. Celles-ci permettent de rencontrer deux objectifs fondamentaux de la politique comparée, à savoir la quête de l’universalité et le refus des explications culturalistes.
La naturalisation de l'appropriation privative
Authors: Guibet Lafaye Caroline 
Published: February 2015

Lorsque la philosophie a voulu penser la propriété et son origine, elle a fait de la nature le cadre approprié pour l’appréhender, y compris à des époques où la propriété, aussi bien privée que commune, était déjà régulée par un système de juridictions préexistant. La propriété et la question de sa légitimité ont alors été interrogées aux confins de l’articulation entre l’ordre du fait (s’incarnant notamment dans l’appropriation) et celui du droit . Néanmoins la mise au premier plan d’une nécessité naturelle ainsi que l’inscription de l’appropriation dans un registre naturaliste ont pour vocation de soustraire la propriété à la problématique de la justice distributive. L’approche naturaliste de l’appropriation privative implique en outre un usage pragmatique de la norme juridique, renversant par là la « loi de Hume », alors même que cette norme pourrait être tout aussi légitimement mobilisée pour instaurer un devoir-être plutôt que pour instituer juridiquement un état de fait. Classification JEL : B12, P14.
Espace d’assistance, espace de pouvoir : les dispositifs d’accueil et d’hébergements dans quelques monastères bénédictins en Normandie aux XIIe et XIIIe siècles
Authors: Gardeux Mathilde 
Published: February 2015

En 2012, une étude du bâti sur l’aile ouest du cloître de l’abbaye de Jumièges (xiie siècle, Seine-Maritime) fut menée dans le cadre d’une thèse sur les structures d’accueil dans les abbayes bénédictines au Moyen Âge. Si ces investigations ont permis d’élaborer une nouvelle hypothèse sur la fonction de cet édifice, elles ont également soulevé de nombreux questionnements sur l’organisation de l’accueil à l’intérieur de l’abbaye. Ainsi, Jumièges fut le point de départ d’une analyse s’étendant à toute la Normandie ducale, en commençant par deux établissements en particulier : l’abbaye Saint-Georges de Boscherville, situé à 17 km de Jumièges, et le Mont-Saint-Michel. Les investigations ont porté sur l’organisation de l’accueil des pauvres comme des hôtes de marque, en joignant l’analyse des sources écrites et des vestiges archéologiques, afin de dessiner une première vue d’ensemble de la topographie de l’accueil et de la place occupée par les laïcs, nobles ou pauvres, à l’intérieur de ces établissements.
Les « Hôtelleries Saint-Hugues » de l’abbaye de Cluny
Authors: Aumard Sylvain , Gaillard Charlotte , Piotrowski Sandra 
Published: February 2015

Les « Hôtelleries Saint-Hugues » furent édifiées durant la grande campagne de construction de Cluny III entreprise par Hugues de Semur (1049-1109). Situé à proximité de la porte d’entrée de l’ancienne abbaye, ce bâtiment s’ouvrait sur une grande cour intérieure qui donnait accès au cloître monastique, bordée au nord par l’avant-nef et au sud par l’aumônerie. Ce bâtiment n’avait finalement fait l’objet que de peu d’investigations jusqu’alors, hormis la solide reconstitution proposée par Kenneth John Connant lors de son travail sur l’abbaye. En 2012, le projet de restauration des élévations orientales et méridionales de l’édifice a ainsi permis de réaliser une étude archéologique sur le bâti concerné, fortement remanié au xixe siècle, accompagné d’une analyse fine de la charpente, appuyée de datations par dendrochronologie. L’étude, confrontée aux résultats issus de divers sondages effectués à l’avant et à l’arrière des bâtiments dans les années 1990, ainsi qu’aux sources graphiques et archivistiques, conduisent à proposer une restitution de l’édifice primitif, remarquable tant par l’ampleur de ses dimensions que par le soin apporté à sa construction.
Immunodeficiency and Autoimmune Enterocolopathy Linked to NFAT5 Haploinsufficiency
Authors: Boland Brigid S. , Widjaja Christella E. , Banno Asoka , Zhang Bing , Kim Stephanie H. , Stoven Samantha , Peterson Michael R. , Jones Marilyn C. , Su H. Irene , Crowe Sheila E. , Bui Jack D. , Ho Samuel B. , Okugawa Yoshinaga , Goel Ajay , Marietta Eric V. , Khosroheidari Mahdieh , Jepsen Kristen , Aramburu Jose , López-Rodríguez Cristina , Sandborn William J. , Murray Joseph A. , Harismendy Olivier , Chang John T. 
Published: February 2015

Abstract
The link between autoimmune diseases and primary immunodeficiency syndromes has been increasingly appreciated. Immunologic evaluation of a young man with autoimmune enterocolopathy and unexplained infections revealed evidence of immunodeficiency, including IgG subclass deficiency, impaired Ag-induced lymphocyte proliferation, reduced cytokine production by CD8+ T lymphocytes, and decreased numbers of NK cells. Genetic evaluation identified haploinsufficiency of NFAT5, a transcription factor regulating immune cell function and cellular adaptation to hyperosmotic stress, as a possible cause of this syndrome. Inhibition or deletion of NFAT5 in normal human and murine cells recapitulated several of the immune deficits identified in the patient. These results provide evidence of a primary immunodeficiency disorder associated with organ-specific autoimmunity linked to NFAT5 deficiency.
Real-Time Tissue Elastography in Gynecology and Obstetrics
Authors: Ryo Eiji 
Published: February 2015

ABSTRACTReports on the use of elastography in gynecology and obstetrics remain scare, and most have used static sonoelastography. In gynecology, most studies are related to the field of oncology. In obstetrics, the primary research object has been to estimate cervical stiffness during pregnancy. The accuracy and reliability of the quantitative evaluation of cervical stiffness using elastography has not yet been established due to the lack of comparative reference materials. More studies are needed to determine the utility of the technique in these fields.How to cite this articleRyo E. Real-Time Tissue Elastography in Gynecology and Obstetrics. Donald School J Ultrasound Obstet Gynecol 2014;8(4):428-436.
HDlive Image of Fetal Endocardial Cushion Defect
Authors: Mashima Masato , Kawanishi Kunihiro 
Published: February 2015

ABSTRACT
We present our first experience of constructing an image of a fetal endocardial cushion defect (ECD) employing HDlive at 21 weeks and 3 days of gestation. Conventional two-dimensional (2D) echocardiography showed an atrioventricular septal defect, bilateral ventricular hypertrophy and massive pericardial effusion. Two-dimensional color Doppler ultrasound revealed atrioventricular valve regurgitation in systole. HDlive clearly demonstrated a glossy atrial septal defect, common atrioventricular valve and bilateral ventricular hypertrophy. Moreover, free, floating leaflets of the common atrioventricular valve not attached to the interventricular septum were suspected using HDlive. These findings suggested complete ECD with congestive heart failure. HDlive provided us with a new, realistic, and arguably much improved view of the complexities and interrelationships of intracardiac structures in a case of fetal ECD. HDlive may assist in the evaluation of fetal EDC, and offer potential advantages relative to conventional 2D fetal echocardiography.

How to cite this article
AboEllail MAM, Hanaoka U, Mashima M, Kawanishi K, Hata T. HDlive Image of Fetal Endocardial Cushion Defect. Donald School J Ultrasound Obstet Gynecol 2014;8(4):437-439.
Term Pregnancy following Myomectomy for Leiomyomatosis
Authors: Achar Suganya , Ramarajan Arulmozhi 
Published: February 2015

ABSTRACTUterine fibroids are common during reproductive age. These are found in up to 77% of women. They may be asymptomatic or may present with pain, menorrhagia, infertility or recurrent pregnancy loss. Symptomatic fibroids often mandate surgical management. These situations pose a challenge when encountered in women undergoing fertility treatment. Achieving a pregnancy following myomectomy depends on the size, number and proximity to the endometrium of the fibroids.Here is the case of a 28-year-old lady, with multiple fibroids, who presented with severe dysmenorrhea and menorrhagia for many years and inability to conceive in 3 years after marriage. She underwent extensive myomectomy. The entire endometrial surface was studded with seedling fibroids, which were scooped out along with much of the endometrium. A diagnosis of uterine leiomyomatosis was made. Three months after surgery, an ultrasound scan of the pelvis showed a bulky uterus of normal contour, endometrial thickness of 7 mm, and multiple tiny fibroids. One year later, she presented with a viable pregnancy of 7 to 8 weeks. She delivered a healthy baby at term.How to cite this articleAchar S, Ramarajan A. Term Pregnancy following Myomectomy for Leiomyomatosis. Int J Infertil Fetal Med 2014;5(3):107-109.
Political Practice The Nexus Between Realisms and Just War Thinking
Authors: KELSAY JOHN 
Published: February 2015

Abstract
Some discussions of the efforts of the United States and its allies in Iraq and Afghanistan between 2001 and 2010 used a distinction between wars of choice and wars of necessity. Wise policymakers know the difference; further, they restrict commitment of military and related resources only to the latter, in which fundamental interests are at stake. As well, wise policymakers understand that those engaged in conflicts of necessity cannot avoid the problem of dirty hands, since the means necessary for the defeat of an enemy may involve violations of established norms. For those who make such arguments, the just war idea seems too restrictive to serve as a guide to statecraft. In this, the choice/necessity distinction echoes themes common to realism, whether in its classic or contemporary forms. And yet just war thinkers through the ages sought to provide guidance for political practice. In particular, the criteria of ius ad bellum and ius in bello aim to guide policymakers in answering the question, In the situation before us, is military force an apt means by which to attain our goals? In this article, my goal is to demonstrate that a concern for wisdom in political practice provides a connection between various types of realism and just war thinking, and thus to develop an account in which these approaches are complementary rather than opposed to one another.
The Fiction of Reinhold Niebuhr as a Political Conservative
Authors: RICE DANIEL F. 
Published: February 2015

Abstract
The attempt to represent Reinhold Niebuhr as a conservative was instigated by his friend Will Herberg in 1956. Niebuhr expressly disavowed Herberg's representation, viewing himself as a realist who was willing to draw on varying insights from the realist tradition from Augustine to Edmund Burke as a means of critiquing the weaknesses he saw in America's social liberals with whom he largely identified. This article examines the historic confusion attached to the terms liberalism and conservatism; explores liberalism and conservatism in the American context, including domestic and foreign policy; and concludes with a treatment of recent neoconservative misappropriation of Niebuhr.
Het fenomeen aanwijzing in de zin van de Rijkswet financieel toezicht Curaçao en Sint Maarten
Authors: Kempes Marloes H. 
Published: February 2015

Het fenomeen aanwijzing in de zin van de Rijkswet financieel toezicht Curaçao en Sint Maarten
Op 10 oktober 2010 is het land Nederlandse Antillen ontmanteld en zijn de nieuwe staatkundige verhoudingen in werking getreden. In het kader van deze staatkundige wijzigingen heeft Nederland zich bereid verklaard schulden van de Nederlandse Antillen en de eilandgebieden te saneren, om op die wijze de nieuwe entiteiten bij te staan bij het creëren van een financieel gezonde uitgangspositie. Ter voorkoming van financiële problemen is overeengekomen dat er toezicht zal worden uitgeoefend door een onafhankelijk orgaan, het College financieel toezicht. Sinds 10 oktober 2010 zijn er twee colleges van kracht. Het College financieel toezicht Bonaire, Sint Eustatius en Saba op grond van de Wet financiën openbare lichamen Bonaire, Sint Eustatius en Saba en het College financieel toezicht Curaçao en Sint Maarten op grond van de (consensus-)Rijkswet financieel toezicht Curaçao en Sint Maarten. De beide colleges worden ondersteund door een gemeenschappelijk secretariaat, kantoorhoudende op Curaçao en op Sint Maarten.
Natural compound methyl protodioscin protects against intestinal inflammation through modulation of intestinal immune responses
Authors: Zhang Rongli , Gilbert Shila , Yao Xinsheng , Vallance Jefferson , Steinbrecher Kris , Moriggl Richard , Zhang Dongsheng , Eluri Madhu , Chen Haifeng , Cao Huiqing , Shroyer Noah , Denson Lee , Han Xiaonan 
Published: February 2015

AbstractDioscoreaceae, a kind of yam plant, has been recommended for treatment of chronic inflammatory conditions. However, the mechanisms are poorly defined. Methyl protodioscin (MPD) is one of the main bioactive components in Dioscoreaceae. Here, we aim to determine the mechanisms by which MPD ameliorates intestinal inflammation. Surgical intestinal specimens were collected from inflammatory bowel diseases (IBD) patients to perform organ culture. Experimental colitis was induced in mice by dextran sulfate sodium (DSS) or Citrobacter rodentium, and was then treated with MPD. NF‐κB activation, expression of mucosal pro‐inflammatory cytokines, disease severity, and epithelial proliferation/apoptosis were determined. Mouse crypts and Caco‐2 monolayers were cultured to observe the effect of MPD upon intestinal epithelial differentiation and barrier function. We found that MPD increased the percentage of survival from high‐dose DSS‐(4%) treated mice, and accelerated mucosal healing and epithelial proliferation in low‐dose DSS‐(2.5%) treated mice characterized by marked reduction in NF‐κB activation, pro‐inflammatory cytokines expression and bacterial translocation. Consistently, MPD protected colonic mucosa from C. rodentium‐induced colonic inflammation and bacterial colonization. In vitro studies showed that MPD significantly increased crypt formation and restored intestinal barrier dysfunction induced by pro‐inflammatory cytokines. In conclusion, MPD ameliorates the intestinal mucosal inflammation by modulating the intestinal immunity to enhance intestinal barrier differentiation. MPD could be an alternative for treating chronic intestinal inflammatory diseases.
Pharmacological effects of recombinant human tissue kallikrein on bradykinin B2 receptors
Authors: Charest‐Morin Xavier , Raghavan Arvind , Charles Matthew L. , Kolodka Tadeusz , Bouthillier Johanne , Jean Mélissa , Robbins Mark S. , Marceau François 
Published: February 2015

AbstractTissue kallikrein (KLK‐1), a serine protease, initiates the release of bradykinin (BK)‐related peptides from low‐molecular weight kininogen. KLK‐1 and the BK B2 receptor (B2R) mediate beneficial effects on the progression of type 2 diabetes and renal disease, but the precise role of KLK‐1 independent of its kinin‐forming activity remains unclear. We used DM199, a recombinant form of human KLK‐1, along with the isolated human umbilical vein, a robust bioassay of the B2R, to address the previous claims that KLK‐1 directly binds to and activates the human B2R, with possible receptor cleavage. DM199 (1–10 nmol/L) contracted the isolated vein via the B2R, but in a tachyphylactic, kinin‐dependent manner, without desensitization of the tissue to exogenously added BK. In binding experiments with recombinant N‐terminally tagged myc‐B2Rs expressed in HEK 293a cells, DM199 displaced [3H]BK binding from the rabbit myc‐B2R, but not from the human or rat myc‐B2Rs. No evidence of myc‐B2R degradation by immunoblot analysis was apparent following treatment of these 3 myc‐B2R constructs with DM199 (30 min, ≤10 nmol/L). In HEK 293 cells stably expressing rabbit B2R‐GFP, DM199 (11–108 pmol/L) elicited signaling‐dependent endocytosis and reexpression, while a higher concentration (1.1 nmol/L) induced a partially irreversible endocytosis of the construct (microscopy), paralleled by the appearance of free GFP in cells (immunoblotting, indicative of incomplete receptor down‐regulation). The pharmacology of DM199 at relevant concentrations (<10 nmol/L) is essentially based on the activity of locally generated kinins. Binding to and mild down‐regulation of the B2R is possibly a species‐dependent idiosyncratic response to DM199.
Human hepatic metabolism of the anti‐osteoporosis drug eldecalcitol involves sterol C4‐methyl oxidase
Authors: Yasuda Kaori , Iwanaga Yuasa , Ogawa Kazuaki , Mano Hiroki , Ueno Sera , Kimoto Shutaro , Ohta Miho , Kamakura Masaki , Ikushiro Shinichi , Sakaki Toshiyuki 
Published: February 2015

AbstractThe metabolism of eldecalcitol (ED‐71), a 2β‐hydroxypropoxylated analog of the active form of vitamin D3 was investigated by using in vitro systems. ED‐71 was metabolized to 1α,2β,25‐trihydroxyvitamin D3 (1α,2β,25(OH)3D3) in human small intestine and liver microsomes. To identify the enzymes involved in this metabolism, we examined NADPH‐dependent metabolism by recombinant P450 isoforms belonging to the CYP1, 2, and 3 families, and revealed that CYP3A4 had the activity. However, the CYP3A4 ‐specific inhibitor, ketoconazole, decreased the activity in human liver microsomes by only 36%, suggesting that other enzymes could be involved in ED‐71 metabolism. Because metabolism was dramatically inhibited by cyanide, we assumed that sterol C4‐methyl oxidase like gene product (SC4MOL) might contribute to the metabolism of ED‐71. It is noted that SC4MOL is physiologically essential for cholesterol synthesis. Recombinant human SC4MOL expressed in COS7, Saccharomyces cerevisiae, or Escherichia coli cells converted ED‐71 to 1α,2β,25(OH)3D3. Furthermore, we evaluated the metabolism of ED‐71 by recombinant CYP24A1, which plays an important role in the metabolism of the active form of vitamin D3 (1α,25(OH)2D3) and its analogs. The kcat/Km value for 24‐ or 23‐hydroxylation of ED‐71 was only 3% of that for 1α,25(OH)2D3, indicating that ED‐71 was resistant to CYP24A1‐dependent catabolism. Among the three enzymes catalyzing ED‐71, SC4MOL appears to be most important in the metabolism of ED‐71. To the best of our knowledge, this is the first study showing that SC4MOL can function as a drug‐metabolizing enzyme. The yeast and E. coli expression systems for SC4MOL could be useful for structure‐function analyses of SC4MOL.
A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N–OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products
Authors: Uchiyama Nahoko , Shimokawa Yoshihiko , Kikura-Hanajiri Ruri , Demizu Yosuke , Goda Yukihiro , Hakamatsuka Takashi 
Published: February 2015

Abstract
Six new psychoactive substances were identified together with two other substances (compounds 1–8) in illegal products by our ongoing survey in Japan between January and July 2014. A new synthetic cannabinoid, FDU-NNEI [1-(4-fluorobenzyl)-N-(naphthalen-1-yl)-1H-indole-3-carboxamide, 2], was detected with the newly distributed synthetic cannabinoid FDU-PB-22 (1). Two 2H-indazole isomers of synthetic cannabinoids, AB-CHMINACA 2H-indazole analog (3) and NNEI 2H-indazole analog (4), were newly identified with 1H-indazoles [AB-CHMINACA and NNEI indazole analog (MN-18)]. In addition, 2-methylpropyl N-(naphthalen-1-yl) carbamate (5) and isobutyl 1-pentyl-1H-indazole-3-carboxylate (6) were detected in illegal products. Compound 6 is considered to be a by-product of the preparation of NNEI indazole analog from compound 5 and 1-pentyl-1H-indazole. A phenethylamine derivative, N–OH-EDMA [N-hydroxy-3,4-ethylenedioxy-N-methylamphetamine, 7], and a cathinone derivative, dimethoxy-α-PHP (dimethoxy-α-pyrrolidinohexanophenone, 8), were newly identified in illegal products. Among them, compounds 1 and 8 have been controlled as designated substances (Shitei-Yakubutsu) under the Pharmaceutical Affairs Law in Japan since August and November 2014, respectively.