bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Implementation of Barrier Device Glass Plug Technology for Enhancement of Well Barriers Assurance Process
Authors: Tleulin Artur , Alromaithi Khaled Butti Suhail Manea , Hussain Mohamed Qassem , Marzouqi Muna Al , Iglesias Danilo 
Published: August 2024

Abstract
This technical paper presents valuable insights and recommendations related to Barrier Devices, commonly known as Glass Plugs, which have been extensively utilized by the largest UAE Oil and Gas Operator to enhance well integrity assurance.
In 2019, the Operator revised its internal Company procedures for verifying completion barriers during well construction. These revisions aligned the practices with international industry standards. As part of this enhancement, the use of Barrier Devices (specifically Glass Plugs) became mandatory during the installation of upper completions in wells capable of establishing natural flow. The decision to adopt Barrier Devices was driven by the need to address challenges associated with conventional slickline operations, including stuck plugs and limitations in depth accessibility due to high inclination angles.
From the beginning of 2023 Operator successfully completed over 400 wells, utilizing Barrier Devices for setting production packers and conducting inflow tests on downhole safety valves. Notably, the Operator emerged as a major global consumer of Barrier Devices, not just within the Middle East.
Access to Barrier Device technologies from various vendors allowed the Operator to accumulate extensive experience with different types of Barrier Devices—ranging from mechanically removed to remotely activated options, each with varying metallurgies and sizes. These Barrier Devices were effectively integrated into Upper (Cased Hole) Completions, serving as an alternative to traditional slickline plugs.
The extensive use of Barrier Devices led the Operator to compile a comprehensive database of lessons learned and practical recommendations. This knowledge is invaluable for future deployments of this novel technology. Additionally, close collaboration with Barrier Device vendors facilitated operational efficiency improvements, enhanced equipment reliability, and ensured alignment with the Operator's Drilling Plan, meeting HSE and well integrity requirements.
Despite a long term existence of glass plug technology on the market, comprehensive details on the selection and efficient usage of these completion tools remain scarce. By sharing insights into technology principles and best practices based on end-user experiences, this paper should benefit other industry professionals.
Mechanical Behavior and Comprehensive Optimization Design of Drill String with Drag Reduction Oscillators in Horizontal Drilling
Authors: Shi Xiaolei , Huang Wenjun , Huang Jincheng , Gao Deli , Ren Qianying 
Published: August 2024

Abstract
The efficiency and safety of drilling operations have increasingly been limited by the friction and torque of the drill string in horizontal wells. Drag reduction oscillators have shown in practice to efficiently lower the drill string's friction force, accelerate rate of penetration, and raise the extension limit. Nonetheless, there is still more to explore on the drill string with drag reduction oscillators’ mechanical behavior and thorough optimization design.
The primary objectives of this paper are stick-slip suppression efficiency and drag reduction efficiency. Taking into account the strong nonlinearity of the friction force and introduction of definite conditions, the model of drill string with drag reduction oscillators is established. Taking into account the torque loss and rotary speed control, the stick-slip vibration model with oscillators is also established. By using an orthogonal test design, the key determinants influencing the stick-slip suppression efficiency and drag reduction efficiency were identified, along with the propagation distance model and the optimal installation location model. Furthermore, the optimal drag reduction parameters and stick-slip suppression parameters are recommended, taking into account drill string buckling, fatigue failure, and hydraulic loss. All the above approaches were utilized in China Jimsar oilfield.
The results demonstrate that the oscillator can efficiently decrease friction force while improving the WOB. The proximity of the oscillator to the drill bit directly correlates with the efficiency of drag reduction. The efficiency of drag reduction is mostly affected by the number of oscillators and the corresponding amplitude, while stick-slip suppression performance is primarily influenced by the rotational speed and WOB. Increasing the rotational speed has greater impact on preventing stick-slip than decreasing the WOB. In this case, it is advisable to install three oscillators with an amplitude of 40 kN, which increases the efficiency of drag reduction by 37.5%. When the optimum rotation speed is 162 r/min and the WOB is 171 kN, the efficiency of the stick-slip suppression is improved by 12.1 %. This study has significant implications for the risk control in horizontal drilling operations and the optimal design of oscillators.
Engineering Design Solutions of Drilling Fluid and Cement Slurry for a Challenging Deep HPHT Carbonate Appraisal Well in Malaysia
Authors: Ong G. S. H. , Chan L. , Ho A. , Udin R. , Kunjirama M. , Nilpetploy V. , Thanasarnpisut V. , Duong A. , Azwar C. 
Published: August 2024

AbstractWell construction in deep high-pressure, high-temperature (HPHT) carbonate wells typically impose the most restrictive restraints and essential requirements for drilling fluid and cementing design and application. This type of well presents specific challenges and difficult technical concerns that must be addressed not only in the drilling phase of the well but also on the long term well integrity. Drilling exploration or an appraisal well accentuates these challenges as formation details may not be fully understood.A recent appraisal well located in offshore Malaysia, presents many challenges especially on the drilling and cementing into its carbonate formation. Among the challenges of completing this HPHT well are high CO2 and H2S exposure, tight equivalent circulating density (ECD) concerns during drilling and cementing, losses from weak interbedded sands and severe losses concerns across its carbonate sections (Karst formation). In the HPHT section of this well, HPHT non-aqueous fluid (NAF) system was designed to meet the criteria for drilling and well test. Also, specially designed self-healing, high temperature flexible and expandable cement was engineered due to concerns of formation subsidence. This set cement design provides flexible properties to cater stress induced by formation movements, coupled with self-healing properties ensuring long term well integrity with its self-repair capabilities. A comprehensive and collaborative approach between drilling fluid and cementing design was among the pivotal factor ensuring the successful well construction of this appraisal well.This paper presents the complete engineering process from coherent well construction planning, drilling fluids and cement slurries design, rigorous laboratory validation, drilling and cementing hydraulic modeling, preventive and collective loss circulation control to successful well drilling execution. It also summarizes the lessons learnt from the operation and recommendations to drill and construct future wells under HPHT environment in this field.
Coiled Tubing Downlines Corrosion and Preservation Experience from Extended Riserless Light Well Intervention Campaigns
Authors: Mammadli R. , Charles E. , Duenas J. , Ramnath L. , Adilov R. , Law M. , Elliott K. J. , Smith R. W. 
Published: August 2024

Abstract
Riserless Light Well Intervention (RLWI) is becoming a more prevalent means to complete needed intervention scopes in deepwater subsea well environments. This is enabled by application of coiled tubing (CT) as downline in a marine environment to facilitate fluid pumping operations versus conveyance through a riser-based system. However, this technique introduces additional factors that affect CT corrosion and service life.
In collaboration with CT supplier Halliburton, bp decided to implement a conservative 6-month CT replacement schedule. The objective of this study was to inspect CT recovered from recent campaigns to evaluate if the 6-month frequency of replacement was fit for purpose.
A coiled tubing (CT) downline inspection was performed on strings recovered from RLWI operations in deepwater Gulf of Mexico (GoM). The CT was sent to the manufacturer for both visual and Electromagnetic Inspection (EMI) analysis to understand the life degradation due to corrosion from exposure to the marine environment. The entire length of coiled tubing was run through the EMI inspection sensor to measure wall thickness and determine the pitting severity.
The visual inspection indicated severe external pitting and corrosion at various sections of CT. Therefore, the pipe was taken out of service and sent for inspection. The initial assessment suggested the marine environment was primarily responsible for the degraded condition. Based on the results and comparison with other CT downline applications from RLWI operations in North Sea and West Africa, the CT replacement and inspection frequency was reevaluated for deepwater GoM. Additionally, improvement opportunities for CT preservation were considered.
CT life degradation during unconventional and consistent use in open water is not widely understood in the industry. As of now, guidelines are not available for application as downline in RLWI operations. The results help to improve understanding, pursue improvement opportunities, and investigate currently conservative approaches while ensuring CT integrity and prevention of RLWI operational failures.
The Efficacy of Rapamycin in Spinal Cord Injury: A Systematic Review and Meta-Analysis of preclinical studies
Authors: Zarei Hamed , Azimi Amir , Ramawad Hamzah Adel , Hajisoltani Razieh , Yousefifard Mahmoud 
Published: August 2024

Abstract

Background
Rapamycin has shown a potential role in functional and neurological recovery after neurodegenerative disease. The current study evaluates the efficacy of Rapamycin in preclinical spinal cord injury (SCI).
Methods
A systematic literature search was conducted in Medline, Embase, Scopus, and Web of Science databases until April 2023. Inclusion criteria were preclinical studies comparing Rapamycin treatment to a control group in animal models of SCI and reporting outcomes including locomotion, apoptosis, autophagy, inflammation, astrogliosis, neuronal counts, and signaling proteins related to the mechanistic target of Rapamycin in Akt/mTOR/p70S6K pathway. Two independent reviewers performed study screening and data extraction. For meta-analyses, a standardized mean difference (SMD) with a 95% confidence interval (CI) was calculated for each experiment and a pooled effect size was reported. The risk of bias and certainty of evidence was assessed using SYRCLE and GRADE tools, respectively.
Results
18 papers were included in the study. Rapamycin significantly decreased apoptosis (TUNEL: SMD − 3.44, 95% CI -5.41 to -1.47; Caspase-3: SMD − 3.85, 95% CI -7.57 to -0.13), inflammation (TNF-α: SMD − 3.26, 95% CI -5.56 to -0.97), astrogliosis (GFAP: SMD − 0.76, 95% CI -1.28 to -0.25), and inhibited Akt/mTOR/p70S6K signaling pathway (SMD − 3.74, 95% CI -6.31 to -1.18). It increased autophagy markers (Beclin-1: SMD 1.42, 95% CI 0.51 to 2.33; LC3-II: SMD 1.09, 95% CI 0.35 to 1.82) and neuronal counts (SMD 1.18, 95% CI 0.44 to 1.91). Locomotion was not significantly influenced by the short-term effects of Rapamycin. However, treatment had significant long-term improvements in locomotion (SMD 0.74–1.54 from 1–6 weeks).
Conclusion
The current study indicates Rapamycin provides neuroprotection, reduces inflammation, enhances autophagy, and improves long-term locomotion in rodent SCI models.
Measurement of Systemic Risk Based on the QRDCCNN Model
Authors: LI JUCHAO , SHENG JILIANG , HUANG YI 
Published: August 2024

Abstract

Measuring and preventing systemic risk have always been core issues in finance. To accurately capture systemic risk, this is the first introduction of the Quantile Regression Dilated Causal Convolution Neural Network (QRDCCNN) model for assessing systemic risk. This model focuses on the causal consistency of financial time series and effectively expands the model's receptive field by increasing the dilation rate layer by layer. The study selects the daily closing prices of the S\&P 500 index and 38 US financial institutions as subjects. The QRDCCNN model is employed to measure the VaR of each financial institution and the CoVaR of the financial system when these institutions are in extreme risk conditions. This paper compares the results of the QRDCCNN model with those from the DCC-GARCH, quantile regression, QRNN, and QRCNN models using the Kupiec test. The research results show that the QRDCCNN model has the highest accuracy, followed by QRNN and QRCNN models, while the DCC-GARCH model has the lowest accuracy.
Umbilical cord-derived mesenchymal stem cells preferentially modulate macrophages to alleviate pulmonary fibrosis
Authors: Li Meng , Li Jun , Wang Ying , Jiang Guancheng , Jiang Hanguo , Li Mengdi , Zhu Ziying , Ren Fangli , Wang Yinyin , Yan Muyang , Chang Zhijie 
Published: August 2024

Abstract

Background
Idiopathic Pulmonary Fibrosis (IPF) is a type of interstitial lung disease characterized by chronic inflammation due to persistent lung damage. Mesenchymal stem cells (MSCs), including those derived from the umbilical cord (UCMSCs) and placenta (PLMSCs), have been utilized in clinical trials for IPF treatment. However, the varying therapeutic effectiveness between these two MSC types remains unclear.
Methods
In this study, we examined the therapeutic differences between UCMSCs and PLMSCs in treating lung damage using a bleomycin-induced pulmonary injury mouse model.
Results
We showed that UCMSCs had a superior therapeutic impact on lung damage compared to PLMSCs. Upon cytokine stimulation, UCMSCs expressed higher levels of inflammation-related genes and more effectively directed macrophage polarization towards the M2 phenotype than PLMSCs, both in vitro and in vivo. Furthermore, UCMSCs showed a preference for expressing CCL2 and CXCL1 compared to PLMSCs. The expression of SPP1, Trem2, and Cebpb in macrophages from mice with the disease treated with UCMSCs was significantly reduced compared to those treated with PLMSCs.
Conclusions
Therefore, UCMSCs demonstrated superior anti-fibrotic abilities in treating lung damage, potentially through inducing a more robust M2 polarization of macrophages than PLMSCs.
Barriers and facilitators to using feedback from clinical quality registries: A systematic scoping review protocol
Authors: Al-Qarni Hussein , Allida Sabine , McDonagh Julee , Ferguson Caleb 
Published: August 2024

Abstract

Background
A clinical quality registry (CQR) is a structured database that systematically collects data to monitor clinical quality and improve healthcare outcomes. The aims of CQRs are: to improve treatment plans, assist in decision-making, increase healthcare value, enhance care quality, and reduce healthcare costs by providing feedback to healthcare providers. Feedback to clinicians is used as a quality improvement tool. It provides data to clinicians about their performance, which may contribute to improvement in healthcare outcomes. To the best of our knowledge, previous research on CQRs has primarily focused on factors affecting their use and their impact on healthcare outcomes. In this study, a systematic scoping review is conducted to understand the barriers to and facilitators of using feedback systems from clinical quality registries in acute healthcare settings.
Methods
For this review, Arksey and O’Malley’s framework for scoping reviews will be applied. The following electronic databases (MEDLINE via Ovid, CINAHL, and Scopus) and grey literature (Google Scholar) will be systematically searched for qualitative and mixed-method studies (only including qualitative findings) published after 2000 in the English language. Two reviewers will independently screen the articles and extract the data which, subsequently, will be mapped against the COM-B model.
Discussion
This review is conducted with the aim of providing valuable insights into the factors that influence the utilisation of feedback from Clinical Quality Registries, which in the context of quality improvement, may have significant implications for clinical research, registry science, health policy, and clinical practice.
Systematic review registration:
This protocol has been registered prospectively with the Open Science Framework (OSF) (https://osf.io/fhm4n/ ).
Selective head-and-neck cooling on biomarker levels and symptom rating following a boxing bout- protocol for an exploratory randomized trial
Authors: Al-Husseini Ali , Tegner Yelverton , Blennow Kaj , Zetterberg Henrik , Marklund Niklas 
Published: August 2024

Abstract

Background
Head impacts are common in contact sports such as boxing and occur at times of elevated core body and brain temperatures induced by the exercise. Following impact, elevated brain temperature may lead to the development of exacerbated brain injury that can be monitored by blood biomarkers. We hypothesized that acute head-and-neck cooling, recently shown to shorten return-to-play in concussed ice hockey players, applied acutely following a boxing bout is associated with an attenuated release of blood biomarkers and improved symptom rating.
Methods
The trial is academically driven and funded by external and hospital research funds. Young, healthy elite boxers ≥ 18 years old are recruited. Prior to, and immediately after a competitive boxing bout over 3x2 or 3x3 minutes, blood samples are drawn. Boxers are randomized to intervention or control management by 1:1 allocation prior to baseline testing. After the initial post-fight blood sample is drawn and symptom rating using the sports concussion assessment tool-5 (SCAT-5) has been collected, the boxers receive either acute selective head-and-neck cooling for 45 min, or routine post-fight management. The number of head impacts are counted in all boxers on match video recordings. In both groups, blood samples are drawn 45 minutes after the initial post-bout blood sample, as well as 3 and 6 days post-fight. At all time points for blood sampling, the number of symptoms (NOS) and symptom severity score (SSS) are assessed using the symptom rating part of the SCAT-5. The primary endpoint is the difference in biomarker levels (GFAP, NF-L, tau, UCH-L1, neuronal-specific enolase) between immediately post-fight and pre-intervention levels, to those obtained at 6 days post-fight. The post-fight SCAT-5 NOS and SSS are secondary endpoints.
Discussion
There is no treatment available for boxing-induced brain injury. Biomarkers are surrogate yet objective marker of brain injury, and the head-and-neck cooling treatment may attenuate the release of brain injury-related biomarkers as well as reduce symptoms induced by head impacts attained during a boxing fight. Potentially, head-and-neck cooling is a treatment option acutely following a boxing bout.
Trials registration
ClinicalTrials.gov, ClinicalTrials.gov Identifier NCT06386484. Registered April 23, 2024.
Dual functional In2O3-PANI-PEDOT Hybrid for Sensing Gallic Acid and Photocatalytic Degradation of Methylene Blue
Authors: Settu Munusamy , Govindhan Gnanamoorthy , Thirugnanam Bavani , Vengidusamy Narayanan 
Published: August 2024

Abstract

In this study, we have investigated the electrocatalytic properties of a nanohybrid composed of In2O3 nanoparticles and a copolymer of PEDOT-PANI. In2O3 nanoparticles, synthesized at 20 and 50 nm sizes, were combined with PANI-PEDOT to form a nanocomposite. The electrocatalytic activity of the nanohybrid was evaluated through catalytic studies using gallic acid (GA) as a model analyte and employing differential pulse voltammetry (DPV). The modified glassy carbon electrode (GCE) exhibited linear responses towards GA in the concentration range of 0.2×10−8 to 1.2×10−9 M, with a sensitivity of 3.102 µA/µM cm−2. The detection limit (DL) and quantification limit (QL) were determined to be 1.108×10-9 and 2.1810×10-9 M µA-1, respectively, indicating the suitability of the nanohybrid for electrochemical sensing applications. Additionally, the nanocomposite demonstrated promising photocatalytic activity, with a maximum efficiency of 98.9% towards methylene blue (MB) degradation within 60 minutes. The interference of reactive hydroxide ions (OHo) formed during the degradation process was observed but did not significantly affect the overall performance. This study highlights the potential of In2O3-PANI-PEDOT nanocomposite for use in electrochemical sensing and photocatalytic applications, with opportunities for further optimization and development of hybrids.
Enhancing Embedding Capacity of Linguistic Steganography Using Arabic Calligraphy
Authors: hamzah Ali A. 
Published: August 2024

Abstract

The limited quantity of redundancy bits in text and the ease with which little alterations may be detected make text a difficult medium for steganography. Linguistic steganography involves hiding data using linguistic characteristics. A language's capability for change increases opportunities to hide information. Many Arabic language elements are currently underutilized in text steganography while being abundant. An assortment of typefaces and forms are used for the Arabic alphabet, for instance in Arabic calligraphy. In this paper, we use the Arabic language's feature extension character (Kashida) with Arabic letter shapes and white space to hide secret bits. This modification uses a linguistic steganography framework that utilizes Arabic calligraphy (AC-STEGA). It tweaks a string-matching algorithm and produces Arabic stego text by a hidden message. In the presented work, a Kashida letter, white space, and multiple shapes of letters based on Arabic font (Naskh) as a case study are employed to hide secret information and increase the capacity of hiding data. The evaluation showed an improvement of 67.3% in capacity compared to 65.4% and 25.4% presented in previous and other similar works. On the security side, the cover represents the secret message itself, so there is no cover used.
YY1 downregulation underlies therapeutic response to molecular targeted agents
Authors: Zhuang Guanglei , Zhou Shichao , Zang Jingyu , Cai Meichun , Ye Kaiyan , Liu Jin , Ma Pengfei , Wu Jie , Dai Chenyang , Lu Haijiao , Zhang Qing , Chu Тianqing , Shen Ying , Tan Li , Zhao Xiaojing , Zhuang Yu , Fu Yujie 
Published: August 2024

Abstract

During targeted treatment, oncogene-addicted tumor cells often evolve from initial drug-sensitive state through a drug-tolerant persister bottleneck towards the ultimate emergence of drug-resistant clones. The molecular basis underlying this therapy-induced evolutionary trajectory is not completely elucidated. Here, we employed a multifaceted approach and implicated a convergent role of transcription factor Yin Yang 1 (YY1) in the course of diverse targeted kinase inhibitors. Specifically, pharmacological perturbation of receptor tyrosine kinase (RTK)/mitogen-activated protein kinase (MAPK) pathway resulted in the downregulation of YY1 transcription, which subsequently resumed upon therapeutic escape. Failure to decrease YY1 subverted cytotoxic effects, whereas eliminating residual YY1 maximized anticancer efficacy and forestalled the emergence of drug resistance. Mechanistically, YY1 was uncovered to dictate cell cycle and autophagic programs. Immunohistochemical analysis on a wide spectrum of clinical specimens revealed that YY1 was ubiquitously expressed across lung adenocarcinomas and exhibited anticipated fluctuation in response to corresponding RTK/MAPK inhibition. These findings advance our understanding of targeted cancer management by highlighting YY1 as a determinant node in the context of genotype-directed agents.