bluuebunny/crossref_metadata_2025_split huggingface dataset:
Monitoring Solid Oxide CO2 Capture Sorbents in Action
Authors: Keturakis Christopher J. , Ni Fan , Spicer Michelle , Beaver Michael G. , Caram Hugo S. , Wachs Israel E. 
Published: October 2014

AbstractThe separation, capture, and storage of CO2, the major greenhouse gas, from industrial gas streams has received considerable attention in recent years because of concerns about environmental effects of increasing CO2 concentration in the atmosphere. An emerging area of research utilizes reversible CO2 sorbents to increase conversion and rate of forward reactions for equilibrium‐controlled reactions (sorption‐enhanced reactions). Little fundamental information, however, is known about the nature of the sorbent surface sites, sorbent surface–CO2 complexes, and the CO2 adsorption/desorption mechanisms. The present study directly spectroscopically monitors Na2O/Al2O3 sorbent–CO2 surface complexes during adsorption/desorption with simultaneous analysis of desorbed CO2 gas, allowing establishment of molecular level structure–sorption relationships between individual surface carbonate complexes and the CO2 working capacity of sorbents at different temperatures.
Akhirin regulates the proliferation and differentiation of neural stem cells in intact and injured mouse spinal cord
Authors: Abdulhaleem M Felemban Athary , Song Xiaohong , Kawano Rie , Uezono Naohiro , Ito Ayako , Ahmed Giasuddin , Hossain Mahmud , Nakashima Kinichi , Tanaka Hideaki , Ohta Kunimasa 
Published: October 2014

ABSTRACTAlthough the central nervous system is considered a comparatively static tissue with limited cell turnover, cells with stem cell properties have been isolated from most neural tissues. The spinal cord ependymal cells show neural stem cell potential in vitro and in vivo in injured spinal cord. However, very little is known regarding the ependymal niche in the mouse spinal cord. We previously reported that a secreted factor, chick Akhirin, is expressed in the ciliary marginal zone of the eye, where it works as a heterophilic cell‐adhesion molecule. Here, we describe a new crucial function for mouse Akhirin (M‐AKH) in regulating the proliferation and differentiation of progenitors in the mouse spinal cord. During embryonic spinal cord development, M‐AKH is transiently expressed in the central canal ependymal cells, which possess latent neural stem cell properties. Targeted inactivation of the AKH gene in mice causes a reduction in the size of the spinal cord and decreases BrdU incorporation in the spinal cord. Remarkably, the expression patterns of ependymal niche molecules in AKH knockout (AKH−/−) mice are different from those of AKH+/+, both in vitro and in vivo. Furthermore, we provide evidence that AKH expression in the central canal is rapidly upregulated in the injured spinal cord. Taken together, these results indicate that M‐AKH plays a crucial role in mouse spinal cord formation by regulating the ependymal niche in the central canal. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 75: 494–504, 2015
Enzyme‐Catalyzed Kinetic Resolution of 2,2,2‐Trifluoro‐1‐(heteroaryl)ethanols: Experimental and Docking Studies
Authors: Kucher Olexandr V. , Kolodiazhnaya Anastasiya O. , Smolii Oleg B. , Prisuazhnyk Dmytro V. , Tolmacheva Katerina A. , Zaporozhets Olga A. , Moroz Yurii S. , Mykhailiuk Pavel K. , Tolmachev Andrey A. 
Published: October 2014

AbstractA convenient approach towards enantiopure (R) and (S) isomers of 2,2,2‐trifluoro‐1‐(heteroaryl)ethanols was developed. The enzyme‐catalyzed kinetic resolution of the corresponding racemic mixtures was achieved by using a two‐step protocol that involved an acylation and a hydrolysis step in the presence of Burkholderia cepacia and CAL‐B lipase (Candida antarctica lipase B), respectively. Fourteen compounds were resolved on a multigram scale by using this approach. The observed enantioselectivities correlated well with the results of molecular docking experiments.
DNA Recognition with Polycyclic‐Aromatic‐Hydrocarbon‐Presenting Calixarene Conjugates
Authors: Rescifina Antonio , Zagni Chiara , Mineo Placido G. , Giofrè Salvatore V. , Chiacchio Ugo , Tommasone Stefano , Talotta Carmen , Gaeta Carmine , Neri Placido 
Published: October 2014

AbstractNew calix[4]arene conjugates that present polycyclic aromatic hydrocarbons (PAHs) at their exo rims have been synthesized by esterification of a cone‐shaped calix[4]arenedicarboxylic acid with trans‐ or cis‐pyrenylisoxazolidinyl alcohols prepared by a 1,3‐dipolar cycloaddition methodology. The in vitro cytotoxic activities of all compounds were evaluated with three different human tumor cell lines, and the most potent one reached an IC50 of 95 nM. The different biological activities of the synthesized compounds were explained by docking and circular dichroism studies, which evidenced their intercalating abilities from the DNA minor groove.
Nickel‐Catalyzed Decarboxylative Arylation of Heteroarenes through sp2 C–H Functionalization
Authors: Yang Ke , Wang Peng , Zhang Cheng , Kadi Adnan A. , Fun Hoong‐Kun , Zhang Yan , Lu Hongjian 
Published: October 2014

AbstractThe direct decarboxylative arylation of hetereoarenes with benzoic acids through a nickel‐catalyzed sp2 C–H functionalization process was developed. This process provides the first examples of decarboxylative cross‐coupling reactions with aromatic acids through nickel catalysis and tolerates a variety of functional groups. Moreover, this method provides efficient access to 2‐aryl‐substituted azoles, an important structural unit in natural products, medicinal compounds, and functional materials.
Electrochemical Characterization of Carbon and Weathering Steels Corrosion Products to Determine the Protective Ability Using Carbon Paste Electrode (CPE)
Authors: Dhaiveegan P. , Elangovan N. , Nishimura T. , Rajendran N. 
Published: October 2014

AbstractThe electrochemistry of the corrosion products formed from carbon and weathering steel during four years of atmospheric exposure were investigated using a carbon paste electrode (CPE) by cyclic and square wave voltammetry. The iron rust products with crystalline nature were identified from their standard formal potential. The corrosion protection ability of the rust layers were determined by polarization and electrochemical impedance spectroscopy studies using CPE. ATR‐FTIR, SEM and XRD studies were employed to identify the composition and morphology of the corrosion products which supports SWV results. Results showed that the weathering steel has higher corrosion resistance than the carbon steel.
Measuring the Electrode Kinetics of Surface Confined Electrode Reactions at a Constant Scan Rate
Authors: Guziejewski Dariusz , Mirceski Valentin , Jadresko Dijana 
Published: October 2014

AbstractThe kinetics of surface confined electrode reactions of alizarin, vitamin B12, and vitamin K2 is measured with square‐wave voltammetry over a wide pH interval, by applying the recent methodology for kinetic analysis at a constant scan rate [V. Mirceski, D. Guziejewski, K. Lisichkov, Electrochim. Acta­ 2013, 114, 667–673]. The reliability and the simplicity of the recent methodology is confirmed. The methodology requires analysis of the peak potential separation of the forward and backward component of the response as a function of the pulse height (SW amplitude), for a given frequency (i.e. constant scan rate) of the potential modulation.
Is Non‐suicidal Self‐injury Related to Impulsivity in Anorexia Nervosa? Results from Self‐report and Performance‐based Tasks
Authors: Claes Laurence , Fagundo Ana B. , Jiménez‐Murcia Susana , Agüera Zaida , Giner‐Bartolome Cristina , Granero Roser , Sánchez Isabel , Riesco Nadine , Menchón Jose Manuel , Tarrega Salomé , Fernandez‐Aranda Fernando 
Published: October 2014

AbstractThe present study investigates the association between non‐suicidal self‐injury (NSSI) and impulsivity in anorexia nervosa (AN) patients by means of self‐report and behavioural tasks. In total, 60 female AN patients were included in the study, filled out the Barratt Impulsiveness Scale‐11 (BIS‐11) and performed three performance‐based tasks to assess different facets of impulsivity. Overall, 30% of the AN patients engaged in at least one form of NSSI during their lifetime. AN patients with and without NSSI did not significantly differ on the BIS‐11 impulsiveness scale. On the performance‐based measures, few differences emerged between AN patients with and without NSSI. Patients with NSSI showed more perseverations and perseveration errors (p < .05). The associations between self‐report and performance‐based measures were rather low, except for the association between the BIS‐11 and Wisconsin Card Sorting Task perseveration responses and errors (correlations |r| range between .32 and .42). The implications for theory and treatment of AN patients with and without NSSI will be discussed. Copyright © 2014 John Wiley & Sons, Ltd and Eating Disorders Association.
Sea stack formation and the role of abrasion on beach‐mantled headlands
Authors: Limber Patrick W. , Murray A. Brad 
Published: October 2014

AbstractSea stacks are common and striking coastal landforms, but few details are known about how, how quickly, and under what conditions they form. We present numerical and analytical models of sea stack formation due to preferential erosion along a pre‐existing headland to address these basic questions. On sediment‐rich rocky coasts, as sea cliffs erode and retreat, they produce beach sediment that is distributed by alongshore sediment transport and controls future sea cliff retreat rates. Depending on their width, beaches can encourage or discourage sea cliff erosion by acting either as an abrasive tool or a protective cover that dissipates wave energy seaward of the cliff. Along the flanks of rocky headlands where pocket beaches are often curved and narrow due to wave field variability, abrasion can accelerate alongshore‐directed sea cliff erosion. Eventually, abrasion‐induced preferential erosion can cut a channel through a headland, separating it from the mainland to become a sea stack. Under a symmetrical wave climate (i.e. equal influence of waves approaching the coastline from the right and from the left), numerical and analytical model results suggest that sea stack formation time and plan‐view size are proportional to preferential erosion intensity (caused by, for example, abrasion and/or local rock weakness from joints, faults, or fractures) and initial headland aspect ratio, and that sea stack formation is discouraged when the sediment input from sea cliff retreat is too high (i.e. sea cliffs retreat quickly or are sand‐rich). When initial headland aspect ratio is too small, and the headland is ‘rounded’ (much wider in the alongshore direction at its base than at its seaward apex), the headland is less conducive to sea stack formation. On top of these geomorphic and morphologic controls, a highly asymmetrical wave climate decreases sea stack size and discourages stack formation through rock–sediment interactions. Copyright © 2014 John Wiley & Sons, Ltd.
Applications and implications of neurochemical biomarkers in environmental toxicology
Authors: Basu Niladri 
Published: October 2014

Abstract

Thousands of environmental contaminants have neurotoxic properties, but their ecological risk is poorly characterized. Contaminant-associated disruptions to animal behavior and reproduction, both of which are regulated by the nervous system, provide decision makers with compelling evidence of harm, but such apical endpoints are of limited predictive or harm-preventative value. Neurochemical biomarkers, which may be used to indicate subtle changes at the subcellular level, may help overcome these limitations. Neurochemical biomarkers have been used for decades in the human health sciences and are now gaining increased attention in the environmental realm. In the present review, the applications and implications of neurochemical biomarkers to the field of ecotoxicology are discussed. The review provides a brief introduction to neurochemistry, covers neurochemical-based adverse outcome pathways, discusses pertinent strengths and limitations of neurochemical biomarkers, and provides selected examples across invertebrate and vertebrate taxa (worms, bivalves, fish, terrestrial and marine mammals, and birds) to document contaminant-associated neurochemical disruption. With continued research and development, neurochemical biomarkers may increase understanding of the mechanisms that underlie injury to ecological organisms, complement other measures of neurological health, and be integrated into risk assessment practices. Environ Toxicol Chem 2015;34:22–29. © 2014 SETAC
Amyloid imaging with [18F]florbetapir in geriatric depression: early‐onset versus late‐onset
Authors: Tateno Amane , Sakayori Takeshi , Higuchi Makoto , Suhara Tetsuya , Ishihara Keiichi , Kumita Shinichiro , Suzuki Hidenori , Okubo Yoshiro 
Published: October 2014

BackgroundWe examined patients with mild cognitive impairment (MCI) with a history of geriatric depression (GD) and healthy controls (HC) to evaluate the effect of beta‐amyloid (Aβ) pathology on the pathology of GD by using [18F]florbetapir PET.MethodsThirty‐three elderly patients (76.7 ± 4.2 years) and 22 healthy controls (HC; 72.0 ± 4.5 years, average ± SD) were examined by [18F]florbetapir positron emission tomography (PET) to quantify the standard uptake value ratio (SUVR) as the degree of amyloid accumulation, by MRI to determine the degree of atrophy, by Mini‐Mental State Examination for cognitive functions, and by Geriatric Depression Scale for the severity of depression, and by Clinical Dementia Rating for activity of daily living (ADL). The cut‐off value of 1.08 for SUVR was defined as Aβ‐positive.ResultsOf the patients and HC, 39.4% and 27.3%, respectively, were beta‐amyloid‐positive. The onset age of GD was significantly correlated with SUVR (r = 0.44, p < 0.01). Compared to patients without Aβ (GD‐Aβ), patients with Aβ (GD + Aβ) did not differ in terms of age, cognitive function, severity of depression and ADL, and brain atrophy. GD + Aβ had significantly older average ± SD age at onset of GD (73.6 ± 7.1 versus 58.7 ± 17.8, p < 0.01) and significantly shorter average ± SD time between onset of GD and PET scan day (3.1 ± 5.2 years versus 18.1 ± 18.6 years, p < 0.001) than GD‐Aβ.ConclusionsOur results showed that the rate of Aβ positivity was higher in late‐onset GD and that onset‐age was associated with SUVR, suggesting that the later the onset of GD, the more Aβ pathology affected its onset. Copyright © 2014 John Wiley & Sons, Ltd.
The effects of antidepressant treatment on resting‐state functional brain networks in patients with major depressive disorder
Authors: Wang Li , Xia Mingrui , Li Ke , Zeng Yawei , Su Yunai , Dai Wenji , Zhang Qinge , Jin Zhen , Mitchell Philip B. , Yu Xin , He Yong , Si Tianmei 
Published: October 2014

AbstractAlthough most knowledge regarding antidepressant effects is at the receptor level, the neurophysiological correlates of these neurochemical changes remain poorly understood. Such an understanding could benefit from elucidation of antidepressant effects at the level of neural circuits, which would be crucial in identifying biomarkers for monitoring treatment efficacy of antidepressants. In this study, we recruited 20 first‐episode drug‐naive major depressive disorder (MDD) patients and performed resting‐state functional magnetic resonance imaging (MRI) scans before and after 8 weeks of treatment with a selective serotonin reuptake inhibitor—escitalopram. Twenty healthy controls (HCs) were also scanned twice with an 8‐week interval. Whole‐brain connectivity was analyzed using a graph‐theory approach—functional connectivity strength (FCS). The analysis of covariance of FCS was used to determine treatment‐related changes. We observed significant group‐by‐time interaction on FCS in the bilateral dorsomedial prefrontal cortex and bilateral hippocampi. Post hoc analyses revealed that the FCS values in the bilateral dorsomedial prefrontal cortex were significantly higher in the MDD patients compared to HCs at baseline and were significantly reduced after treatment; conversely, the FCS values in the bilateral hippocampi were significantly lower in the patients at baseline and were significantly increased after treatment. Importantly, FCS reduction in the dorsomedial prefrontal cortex was significantly correlated with symptomatic improvement. Together, these findings provided evidence that this commonly used antidepressant can selectively modulate the intrinsic network connectivity associated with the medial prefrontal‐limbic system, thus significantly adding to our understanding of antidepressant effects at a circuit level and suggesting potential imaging‐based biomarkers for treatment evaluation in MDD. Hum Brain Mapp 36:768–778, 2015. © 2014 Wiley Periodicals, Inc.
Use of inpatient palliative care services in patients with metastatic incurable head and neck cancer
Authors: Mulvey Carolyn L. , Smith Thomas J. , Gourin Christine G. 
Published: October 2014

AbstractBackgroundSubstantial health care resources are used on aggressive end‐of‐life care, despite an increasing recognition that palliative care improves quality of life and reduces health care costs. We examined the incidence of palliative care encounters in in‐patients with incurable head and neck cancer and associations with in‐hospital mortality, length of hospitalization, and costs.MethodsData from the Nationwide Inpatient Sample (NIS) for 80,514 head and neck cancer patients with distant metastatic disease in 2001 to 2010 was analyzed using cross‐tabulations and multivariate regressions.ResultsPalliative care encounters occurred in 4029 cases (5%) and were significantly associated with age ≥80 years, female sex, self‐pay payor status, and prior radiation. Palliative care was significantly associated with increased in‐hospital mortality and reduced hospital‐related costs.ConclusionInpatient palliative care consultation in terminal head and neck cancer is associated with reduced hospital‐related costs, but appears to be underutilized and restricted to the elderly, uninsured, and patients with an increased risk of mortality. © 2015 Wiley Periodicals, Inc. Head Neck 38: 355–363, 2016
Biomineralized hydroxyapatite nanoclay composite scaffolds with polycaprolactone for stem cell‐based bone tissue engineering
Authors: Ambre Avinash H. , Katti Dinesh R. , Katti Kalpana S. 
Published: October 2014

AbstractNanoclay modified with unnatural amino acid was used to design a nanoclay‐hydroxyapatite (HAP) hybrid by mineralizing HAP in the nanoclay galleries mimicking biomineralization. This hybrid (in situ HAPclay) was used to fabricate polycaprolactone (PCL)/in situ HAPclay films and scaffolds for bone regeneration. Cell culture assays and imaging were used to study interactions between human mesenchymal stem cells (hMSCs) and PCL/in situ HAPclay composites (films and scaffolds). SEM imaging indicated MSC attachment, formation of mineralized extracellular (ECM) on PCL/in situ HAPclay films, and infiltration of MSCs to the interior of PCL/in situ HAPclay scaffolds. Mineralized ECM was formed by MSCs without use of osteogenic supplements. AFM imaging performed on this in vitro generated mineralized ECM on PCL/in situ HAPclay films revealed presence of components (collagen and mineral) of hierarchical organization reminiscent of natural bone. Cellular events observed during two‐stage seeding experiments on PCL/in situ HAPclay films indicated similarities with events occurring during in vivo bone formation. PCL/in situ HAPclay films showed significantly increased (100–595% increase in elastic moduli) nanomechanical properties and PCL/in situ HAPclay scaffolds showed increased degradation. This work puts forth PCL/in situ HAPclay composites as viable biomaterials for bone tissue engineering. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 2077–2101, 2015.
Analytical techniques used for the characterization and authentification of six ancient religious manuscripts (XVIII–XIX centuries)
Authors: Vornicu Nicoleta , Deselnicu Viorica , Bibire Cristina , Ivanov Daniela , Doroftei Florica 
Published: October 2014

ABSTRACTThis article presents the experimental results of a research on six manuscripts (three of the XVIII century and three of XIX century) belonging collection of old religious books to the Moldovan Metropolitan Church of Romania. Non‐invasive techniques (optical microscopy [OM], scanning electron microscopy/energy dispersive X‐ray system, X‐ray fluorescence analysis, shrinkage temperature, and Fourier transform infrared spectroscopy/attentuated total reflectance) provided information on the degree of degradation and identification of the leather bookbinding type. Moreover, visual assessment and OM revealed the extent of the surface degradation (wane, biological attack, change color, etc.). The degradation extent of the skin bindings was determined on the 12 samples. The insight on the mechanism of degradation was accomplished by analyzing the deterioration of collagen fibers in terms of shrinkage temperature and chemical modifications induced by oxidative and hydrolytic processes. Shrinkage temperature values were lower compared with the literature data for collagen, indicating that the leather bookbinding suffered intrinsic damage. Morphological analysis was accomplished by microscopy and allowed the identification of skin type and provided information about its processing technique. Mineral elements were identified for leather composition and contributed to the information regarding the origin and the extent of degradation of the leather bookbinding, of the studied manuscripts. The analyzed results were useful in determining the state of preservation and were able to provide an increased efficiency of further restoration. The correlation of the obtained data brought new contributions to the knowledge of the leather covers for the book technique in the XVIII and XIX centuries in monastic workshops of Eastern Europe. Microsc. Res. Tech. 78:70–84, 2015. © 2014 Wiley Periodicals, Inc.