bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current evidence supporting associations of DNA methylation measurements with survivorship burdens in cancer survivors: A scoping review
Authors: Sayer Michael , Ng Ding Quan , Chan Raymond , Kober Kord , Chan Alexandre 
Published: July 2024

AbstractIntroductionIdentifying reliable biomarkers that reflect cancer survivorship symptoms remains a challenge for researchers. DNA methylation (DNAm) measurements reflecting epigenetic changes caused by anti‐cancer therapy may provide needed insights. Given lack of consensus describing utilization of DNAm data to predict survivorship issues, a review evaluating the current landscape is warranted.ObjectiveProvide an overview of current studies examining associations of DNAm with survivorship burdens in cancer survivors.MethodsA literature review was conducted including studies if they focused on cohorts of cancer survivors, utilized peripheral blood cell DNAm data, and evaluated the associations of DNAm and survivorship issues.ResultsA total of 22 studies were identified, with majority focused on breast (n = 7) or childhood cancer (n = 9) survivors, and half studies included less than 100 patients (n = 11). Survivorship issues evaluated included those related to neurocognition (n = 5), psychiatric health (n = 3), general wellness (n = 9), chronic conditions (n = 5), and treatment specific toxicities (n = 4). Studies evaluated epigenetic age metrics (n = 10) and DNAm levels at individual CpG sites or regions (n = 12) for their associations with survivorship issues in cancer survivors along with relevant confounding factors. Significant associations of measured DNAm in the peripheral blood samples of cancer survivors and survivorship issues were identified.Discussion/ConclusionStudies utilizing epigenetic age metrics and differential methylation analysis demonstrated significant associations of DNAm measurements with survivorship burdens. Associations were observed encompassing diverse survivorship outcomes and timeframes relative to anti‐cancer therapy initiation. These findings underscore the potential of these measurements as useful biomarkers in survivorship care and research.
Klebsiella pneumoniae‐infected hemorrhagic ulcerative infantile hemangioma: A rare complication
Authors: Abtahi‐Naeini Bahareh , Pourmahdi‐Boroujeni Mahsa , Alipour Narjes , Sattari Hossein , Pourmoghaddas Zahra 
Published: July 2024

Key Clinical MessageInfections in infantile hemangiomas (IHs) are generally limited, and only few cases have been reported. The rapid expansion of an ulcerated IH should raise concern for possible complications to monitor and provide immediate therapeutic interventions. This case highlights the importance of prompt treatment in large segmental IHs to prevent ulceration and related complications, including bleeding and superinfection.AbstractIH is a benign tumor proliferating during early infancy. While many IHs spontaneously resolve, complications like ulceration, bleeding, and potential damage to vital organs can occur, leading to pain, infection, and scarring. A 6‐month‐old girl with a previously treated IH on her left leg developed a Klebsiella‐infected ulcer at the site. The ulcer resulted from non‐standard treatments used before admission. Upon hospitalization, she was initially treated with cefepime and propranolol, but a week later, the wound culture revealed Klebsiella pneumoniae, prompting a switch to piperacillin/tazobactam. After successfully managing the infection and bleeding, the child was discharged in good condition with orders to continue treatment with propranolol for at least a year. This case highlights the potential of IHs to become infected even with uncommon germs such as Klebsiella and the importance of receiving appropriate medical care to prevent further complications.
Expanding the Role of Chiral Drugs and Chiral Nanomaterials as a Potential Therapeutic Tool
Authors: Satapathy Sourabh , Kumar Shivam , Kurmi Balak Das , Gupta Ghanshyam Das , Patel Preeti 
Published: July 2024

ABSTRACTChirality, the property of molecules having mirror‐image forms, plays a crucial role in pharmaceutical and biomedical research. This review highlights its growing importance, emphasizing how chiral drugs and nanomaterials impact drug effectiveness, safety, and diagnostics. Chiral molecules serve as precise diagnostic tools, aiding in accurate disease detection through unique biomolecule interactions. The article extensively covers chiral drug applications in treating cardiovascular diseases, CNS disorders, local anesthesia, anti‐inflammatories, antimicrobials, and anticancer drugs. Additionally, it explores the emerging field of chiral nanomaterials, highlighting their suitability for biomedical applications in diagnostics and therapeutics, enhancing medical treatments.
Auswirkungen der Energiewende auf die Stromnetze
Authors: Siebels Carsten 
Published: July 2024

ZusammenfassungDie Energiewende in Deutschland erfordert in den nächsten zwanzig Jahren neben einer Vielzahl neuer Wind‐ und Solaranlagen die Umstellung der Wärmeversorgung und des Verkehrs auf elektrische Energie. Hinzu kommt ein hoher Strombedarf für Elektrolyseanlagen zur Herstellung von Wasserstoff. Die dafür erforderliche Ausbauplanung des Übertragungsnetzes erfolgt heute ohne Bewertung von Wirtschaftlichkeit und Belastung der Landschaft. Es wird als Alternative zum überdimensioniert geplanten Ausbau des Übertragungsnetzes vorgeschlagen, ein zweites Strommarktgebiet in Deutschland zu schaffen.
Excitatory Projections of Wide Field Collicular Neurons to the Nucleus of the Optic Tract in the Rat
Authors: Tzanou Athanasia , Theodorou Eirini , Mantas Ioannis , Dalezios Yannis 
Published: July 2024

ABSTRACTThe superficial layers of the mammalian superior colliculus (SC) contain neurons that are generally responsive to visual stimuli but can differ considerably in morphology and response properties. To elucidate the structure and function of these neurons, we combined extracellular recording and juxtacellular labeling, detailed anatomical reconstruction, and ultrastructural analysis of the synaptic contacts of labeled neurons, using transmission electron microscopy. Our labeled neurons project to different brainstem nuclei. Of particular importance are neurons that fit the morphological criteria of the wide field (WF) neurons and whose dendrites are horizontally oriented. They display a rather characteristic axonal projection pattern to the nucleus of optic tract (NOT); thus, we call them superior collicular WF projecting to the NOT (SCWFNOT) neurons. We corroborated the morphological characterization of this neuronal type as a distinct neuronal class with the help of unsupervised hierarchical cluster analysis. Our ultrastructural data demonstrate that SCWFNOT neurons establish excitatory connections with their targets in the NOT. Although, in rodents, the literature about the WF neurons has focused on their extensive projection to the lateral posterior nucleus of the thalamus, as a conduit for information to reach the visual association areas of the cortex, our data suggest that this subclass of WF neurons may participate in the optokinetic nystagmus.
Where Do Core Thalamocortical Axons Terminate in Mammalian Neocortex When There Is No Cytoarchitecturally Distinct Layer 4?
Authors: Bhagwandin Adhil , Molnár Zoltán , Bertelsen Mads F. , Karlsson Karl Æ. , Alagaili Abdulaziz N. , Bennett Nigel C. , Hof Patrick R. , Kaswera‐Kyamakya Consolate , Gilissen Emmanuel , Jayakumar Jaikishan , Manger Paul R. 
Published: July 2024

ABSTRACTAlthough the mammalian cerebral cortex is most often described as a hexalaminar structure, there are cortical areas (primary motor cortex) and species (elephants, cetaceans, and hippopotami), where a cytoarchitecturally indistinct, or absent, layer 4 is noted. Thalamocortical projections from the core, or first order, thalamic system terminate primarily in layers 4/inner 3. We explored the termination sites of core thalamocortical projections in cortical areas and in species where there is no cytoarchitecturally distinct layer 4 using the immunolocalization of vesicular glutamate transporter 2, a known marker of core thalamocortical axon terminals, in 31 mammal species spanning the eutherian radiation. Several variations from the canonical cortical column outline of layer 4 and core thalamocortical inputs were noted. In shrews/microchiropterans, layer 4 was present, but many core thalamocortical projections terminated in layer 1 in addition to layers 4 and inner 3. In primate primary visual cortex, the sublaminated layer 4 was associated with a specialized core thalamocortical projection pattern. In primate primary motor cortex, no cytoarchitecturally distinct layer 4 was evident and the core thalamocortical projections terminated throughout layer 3. In the African elephant, cetaceans, and river hippopotamus, no cytoarchitecturally distinct layer 4 was observed and core thalamocortical projections terminated primarily in inner layer 3 and less densely in outer layer 3. These findings are contextualized in terms of cortical processing, perception, and the evolutionary trajectory leading to an indistinct or absent cortical layer 4.
Interplay of national and firm environmental, social, and governance performances: Reshaping multinational enterprises' employer attractiveness across home and host countries
Authors: Kuo Anthony , Chien Donna , Kao Ming‐Sung 
Published: July 2024

AbstractIn this study, we emphasize the pivotal role of national environmental, social, and governance (ESG) performance, encompassing both host and home countries, in shaping the implications of firm‐specific ESG performance for the attractiveness of multinational enterprises (MNEs) as preferred employers. Our research puts forth three hypotheses. First, we propose that superior ESG performance by MNEs will exhibit a positive relationship with their perceived appeal as employers. Second, we theorize that higher national ESG performance in the home country will amplify the positive relationship between an MNE's ESG performance and its attractiveness as an employer. Lastly, we posit that superior national ESG performance in the host country will similarly strengthen the positive association between an MNE's ESG performance and its desirability as an employer. The empirical data robustly supports these hypotheses.
A high‐PCE amalgamate charge pump topology with extended input voltage dynamic range for energy harvesting systems
Authors: Yong Jack Kee , Zhou Qi Huan , Ho Tian Siang , Ramiah Harikrishnan 
Published: July 2024

AbstractThis paper presents a novel extended input voltage dynamic range (IVDR) amalgamate charge pump (CP) for energy harvesting systems. The proposed amalgamate CP adaptively switches its charge transfer transistor into switch and diode connection based on the input voltage, effectively enhancing the power conversion efficiency (PCE) over a wide input voltage range. Implemented in 65 nm CMOS technology, the post‐layout results demonstrate a PCE exceeding 40% within the input voltage range of 0.36–0.85 V, under 60 kΩ load. The design achieves an extended IVDR of 0.49 V with a peak PCE of 50.02% observed at an input voltage of 0.45 V. The proposed amalgamate CP design features two distinct charge transfer transistor connections, leveraging the strength of Dickson CP with low reversion loss in high input voltage range and the low conduction loss of cross‐coupled CP (CCCP) in low input voltage range, thereby extending the input voltage operation range of conventional CP.
An innovative method is applied to solve the equivalent resistance between any nodes of a 2 × 4 × n tower‐shaped cascaded resistive network
Authors: Luo Da‐Feng , Luo Feng‐Hua , Luo Li‐Jin 
Published: July 2024

AbstractIn previous methods for solving the equivalent resistance of large‐scale complex resistive networks, abstract Green's functions or complex matrix transformations were often involved, which brought more difficulties to the readers' understanding. For this reason, this study proposed an innovative method based entirely on simple algebraic operations. This method combined the equivalent decomposition method with the improved recursion‐transform (IRT) method. It was divided into three steps: Firstly, by introducing the concept of “negative resistance,” one of the resistors of the network to be solved was equivalently decomposed into the parallel connection of three resistors, so that the whole resistive network was equivalently decomposed into three parts, namely, a left network, a middle network, and a right network. Then, the equivalent resistances of the left network and the right network were calculated using the IRT method, respectively. Finally, the equivalent resistance between any nodes was solved according to the parallel relationship of the equivalent resistances of the left network, the middle network, and the right network. The equivalent resistance between any nodes in the 2 × 4 × n tower‐shaped cascaded resistive network was successfully solved using this method. The calculation showed that because the concept of negative resistance was introduced in this method, the equivalent resistance problem of any nodes in the network was changed into the equivalent resistance problem of the initial nodes of the network, which made the equivalent resistance problem of any nodes simple, convenient, fast and easy to understand.
Phylogenetic and phylogeographic evidence for the colonization success of the diplochorous Astydamia latifolia across the Canary Islands
Authors: Coello Alberto J. , Vargas Pablo , Alameda‐Martín Aitor , Cano Emilio , Arjona Yurena , Fernández‐Mazuecos Mario 
Published: July 2024

AbstractAstydamia latifolia is the only species of the genus Astydamia, which forms an early‐diverging lineage of Apiaceae, subfamily Apioideae. This species is subendemic to the Canary Islands and one of the most representative species of the coastal environments of this archipelago. Astydamia displays diplochory, that is, diaspores with two long‐distance dispersal (LDD) syndromes. In particular, A. latifolia has both anemochorous and thalassochorous fruit traits (corky and winged mericarps). Although we expect this species to have a high dispersal capacity, there is no genetic study addressing it. The divergence time of this species from its sister taxon is also unknown. In this study, we aimed (i) to unveil the phylogenetic relationships and divergence times of A. latifolia; (ii) to reconstruct its phylogeographic structure across the Canary Islands; and (iii) to estimate the number of inter‐island colonization events. To these ends, we first sequenced the internal transcribed spacer (ITS) region for A. latifolia, reconstructed the phylogenetic relationships of Astydamia and Apiaceae relatives and estimated divergence times. Then, two plastid DNA regions (psaI‐aacD and psbK‐trnS) were sequenced for 158 individuals (from 36 Canarian population and one NW African population) to reconstruct a haplotype network. The recently developed method Phylogeographic Analysis of Island Colonization Events (PAICE) was used to estimate the number of inter‐island colonization events. Results show that A. latifolia is a phylogenetically isolated lineage that diverged from the most closely related genus (Molopospermum) in the Eocene–Miocene. It displays a low plastid DNA diversity (only four haplotypes detected), which is accompanied by a high degree of haplotype sharing between islands and highly linear rarefaction curves of colonization obtained in PAICE. These findings suggest a high colonization ability for this species, most likely related to the availability of two LDD syndromes.
Experimental evaluation of genetic variability based on DNA metabarcoding from the aquatic environment: Insights from the Leray COI fragment
Authors: Turanov S. V. , Koltsova M. A. , Rutenko O. A. 
Published: July 2024

AbstractIntraspecific genetic variation is important for the assessment of organisms' resistance to changing environments and anthropogenic pressures. Aquatic DNA metabarcoding provides a non‐invasive method in biodiversity research, including investigations at the within‐species level. Through the analysis of eDNA samples collected from the Peter the Great Gulf of the Japan Sea, in this study, we aimed to evaluate the identification of Amplicon Sequence Variants (ASVs) in marine eDNA among abundant species of the Zostera sp. community: Hexagrammos octogrammus, Pholidapus dybowskii (Teleostei: Perciformes), and Pandalus latirostris (Arthropoda: Decapoda). These species were collected from two distant locations to produce mock communities and gather aquatic eDNA both on the community and individual level. Our approach highlights the efficacy of eDNA metabarcoding in capturing haplotypic diversity and the potential for this methodology to track genetic diversity accurately, contributing to conservation efforts and ecosystem management. Additionally, our results elucidate the impact of nuclear mitochondrial DNA segments (NUMTs) on the reliability of metabarcoding data, indicating the necessity for cautious interpretation of such data in ecological studies. Moreover, we analyzed 83 publicly available COI sequence datasets from common groups of multicellular organisms (Mollusca, Echinodermata, Crustacea, Polychaeta, and Actinopterygii). The results reflect the decrease in population diversity that arises from using the metabarcode compared to the COI barcode.
Ecological drivers of nesting behavior in a subtropical city: An observational study on spotted doves
Authors: Sheng Yao , Lu Mengjie , Bai Junpeng , Xie Xiaobin , Ma Long , Li Wanyou , Zhang Zhen , Ming Fang , Zhang Xueli , Zhang Ziwei , Xu Zhifeng , Han Yuqing , Guan Bicai , Ruan Luzhang 
Published: July 2024

AbstractDue to rapid homogenization in habitat types as a result of urbanization, some urban birds adapt their nesting strategies to changes in local habitat characteristics. Bird nesting decisions might have been mainly linked to resource constraints and ensuring reproductive success. In this study, we examined patterns of nesting behavior by spotted doves (Spilopelia chinensis) in a rapidly urbanizing area of Nanchang, China using ArcGIS 10.8, satellite tracking, camera traps, and field survey. To explore the mechanisms underlying nesting behavior in urban habitats, we assessed the correlations between nest reuse and reproductive success, and between nest reuse and nest predation. From December 2018 to December 2021, a total of 302 breeding nests were surveyed. The results revealed that the nest reuse rate was 38.08% (n = 115). Nests closer to trunk, with lower nest position and higher large‐scale urbanization score tended to have higher reuse rate. In addition, nests with the higher the nest height and percent of canopy cover, and the lower small‐scale urbanization score were more likely to reproduce successfully, and the reused nests also reproduce more successfully. The reproductive success associated with nest reuse was significantly higher than that associated with new nests (χ2 = 8.461, p = .004). High degree of urbanization promoted nest reuse of spotted doves (large‐scale urbanization score, z = 2.094, p = .036), which apparently enhanced their reproductive success (nest reuse, z = 2.737, p = .006). In conclusion, a nest structure with good permeability is the material basis for the nest reuse in spotted dove, while the relatively low risk of predation in urban habitat and the scarcity of nest site resources due to urbanization increase the tendency of birds to reuse old nests, which is associated with their reproductive success and evolutionary fitness.
Dilute concentrations of maritime fuel can modify sediment reworking activity of high‐latitude marine invertebrates
Authors: Williams Thomas J. , Blockley David , Cundy Andrew B. , Godbold Jasmin A. , Howman Rebecca M. , Solan Martin 
Published: July 2024

AbstractMultiple expressions of climate change, in particular warming‐induced reductions in the type, extent and thickness of sea ice, are opening access and providing new viable development opportunities in high‐latitude regions. Coastal margins are facing these challenges, but the vulnerability of species and ecosystems to the effects of fuel contamination associated with increased maritime traffic is largely unknown. Here, we show that low concentrations of the water‐accommodated fraction of marine fuel oil, representative of a dilute fuel oil spill, can alter functionally important aspects of the behaviour of sediment‐dwelling invertebrates. We find that the response to contamination is species specific, but that the range in response among individuals is modified by increasing fuel concentrations. Our study provides evidence that species responses to novel and/or unprecedented levels of anthropogenic activity associated with the opening up of high‐latitude regions can have substantive ecological effects, even when human impacts are at, or below, commonly accepted safe thresholds. These secondary responses are often overlooked in broad‐scale environmental assessments and marine planning yet, critically, they may act as an early warning signal for impending and more pronounced ecological transitions.
Characterizing localized nitrogen sensitivity of tree species and the associated influences of mediating factors
Authors: Coughlin Justin G. , Chang Shih Ying , Craig Kenneth , Scarborough Charles , Driscoll Charles T. , Clark Christopher M. , Pavlovic Nathan R. 
Published: July 2024

AbstractCritical loads (CLs) are frequently used to quantify terrestrial ecosystem impacts from nitrogen (N) deposition using ecological responses such as the growth and mortality of tree species. Typically, CLs are reported as a single value, with uncertainty, for an indicator across a species' entire range. Mediating factors such as climate and soil conditions can influence species' sensitivity to N, but the magnitudes of these effects are rarely calculated explicitly. Here, we quantify the spatial variability and estimation error in N CLs for the growth and survival of 10 different tree species while accounting for key environmental factors that mediate species sensitivity to N (e.g., soil characteristics). We used a bootstrapped machine learning approach to determine the level of N deposition at which a 1% decrease occurs in growth rate or survival probability at forest plot locations across the United States. We found minimal differences (<5 kg N ha−1 year−1) when comparing a single species' CLs across climatic regimes but found considerable variability in species' local N CLs (>8.5 kg N ha−1 year−1) within these regimes. We also evaluated the most important factors for predicting tree growth rates and mortality and found that climate, competition, and air pollution generally have the greatest influence on growth rates and survival probability. Lastly, we developed a new probability of exceedance metric for each species and found high likelihoods of exceedance across large portions (46%) of some species' ranges. Our analysis demonstrates that machine learning approaches provide a unique capability to: (1) quantify mediating factor influences on N sensitivity of trees, (2) estimate the error in local N CL estimates, and (3) generate localized N CLs with probabilities of exceedance for tree species.