bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating urban development and ecological sustainability: a study on land surface temperature and urban heat island effect in a Karst River Basin
Authors: Wu Yangyang , Wu Haobiao , Li Siliang , Wu Liqing , Guo Chunzi , Zhang Zhonghua , Fan Ruixue , Yang Xiaodong , Zhou Guanghong , Yang Jinli , Yuan Panli , Luo Guangjie 
Published: August 2024

The Chishui River Basin, a vital waterway in Southwest China, has experienced rapid urbanization, leading to significant ecological and environmental changes, among which the urban heat island (UHI) effect is particularly pronounced. The UHI effect not only affects the quality of life for residents but also influences urban energy consumption and climate change, underscoring the need for in-depth study of its spatial distribution and contributing factors. The unique karst topography of the region further complicates UHI research, necessitating an investigation that can inform urban planning and sustainable development strategies. This study leveraged Landsat 8 TIRS satellite remote sensing imagery to examine the land surface temperature (LST) and UHI effect in the Chishui River Basin during the summers of 2016 and 2021. Employing the Mono-window Algorithm (MWA), the research quantitatively inverted the LST and analyzed its spatial distribution and the spatiotemporal characteristics of the surface urban heat island (SUHI) effect. The findings indicated a notable increase in average summer temperatures between the 2 years, with a 1.67°C rise from 2016 to 2021. Despite this increase, there was an observed reduction in the extent of SUHI areas, suggesting potential mitigation efforts. Additionally, the study revealed that karst regions were more susceptible to forming “abnormal” heat islands due to their distinct geomorphological features. The implications of this research are critical for urban development planning and the pursuit of sustainable urbanization in the Chishui River Basin. By understanding the thermal dynamics and their relationship with urbanization and karst landscapes, policymakers and urban planners can devise strategies to minimize the adverse effects of SUHI while promoting ecological balance and environmental health. Future research should extend the temporal analysis, employ higher resolution data, compare findings with other regions, and provide a detailed examination of mitigation efforts to enhance the robustness and applicability of the conclusions, provide stronger scientific evidence for the ecological sustainability of the Chishui River Basin.
Associations between SII, SIRI, and cardiovascular disease in obese individuals: a nationwide cross-sectional analysis
Authors: Liu Zhou , Zheng Longxuan 
Published: August 2024

BackgroundSystemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are comprehensive markers of inflammatory status. However, the correlation between SII and SIRI and the prevalence of cardiovascular disease (CVD) in populations with obesity remains unknown.MethodsThis is a cross-sectional study with data obtained from the National Health and Nutrition Examination Survey from 1999 to 2018. SII and SIRI were calculated using the following equations: SII = (platelet count × neutrophil count)/lymphocyte count. SIRI = (neutrophil count × monocyte count)/lymphocyte count. Spearman’s rank correlation coefficient was used to assess the relationship between SII and SIRI and baseline variables. Logistic regression models and generalized additive model (GAM) with a spline smoothing function were used to evaluate the association between SIRI and CVD prevalence. Nomogram and receiver operating characteristic curve (ROC) analysis were used to assess the value of the risk prediction model.ResultsA total of 17,261 participants with obesity and SII and SIRI publicly available data were used for this study. Multivariate logistic regression analysis revealed that SIRI, rather than SII, was an independent risk factor for CVD prevalence. For every standard deviation increase in SIRI, there was a 13%, 15%, and 28% increase in the odds ratios of CVD prevalence (OR = 1.13, 95% CI: 1.04–1.22, P = 0.01), coronary heart disease (OR = 1.15, 95% CI: 1.05–1.26, P = 0.002), and congestive heart failure (OR = 1.28, 95% CI: 1.16–1.41, P &lt; 0.001). ROC results demonstrated that SIRI had a certain accuracy in predicting CVD prevalence (AUC = 0.604), especially when combined with other variables used in the nomogram (AUC = 0.828). The smooth curve fitting regression analysis demonstrated a significant linear association between the risk of SIRI and the odds ratio of CVD prevalence (P for nonlinear = 0.275).ConclusionsSIRI is a relatively stable indicator of inflammation and is independently associated with the prevalence of CVD. It may serve as a novel inflammatory indicator to estimate CVD prevalence in populations with obesity.
Developing mindsets for equity-focused continuous improvement: tracing shifts in an Ed.D. program using critical improvement science
Authors: Zumpe Elizabeth , Uy Phitsamay S. , Hakouz Abeer , Szczesiul Stacy Agee 
Published: August 2024

IntroductionTwo rising innovations in educational leadership development—using an equity lens and facilitating continuous improvement (CI)—depend upon leaders developing conducive mindsets for the work. However, little research has examined how educational leaders come to develop equity-focused CI mindsets. This is important given that countervailing habits of thinking are likely to develop within leaders’ typical work environments. This paper traces the extent to which an Ed.D. program centered around a pedagogy of critical improvement science can foster shifts from typical habits of thinking towards equity-focused CI mindsets.MethodsData consisted of 13 assignments and semi-structured interviews of six Ed.D. students participating in two parallel and interconnected courses during their first term. The two courses culminated in a common assessment: a White Paper about their equity-focused problem of practice and how their social identities shaped their understanding and role in addressing the problem. Through coding, analytic memos, and member checking, we traced patterns and shifts in students’ thinking over time around five key domains of learning: problem identification, problem diagnosis, use of evidence, social identity, and equity leadership practices.ResultsWe found emergent mindset shifts for all six participants across all learning domains. Students demonstrated new insights about problem analysis and becoming evidence-informed and user-centered, challenging their initial framing of problems through a systems approach to diagnosing problem. These insights intersected with new understandings of their social identities and practices as equity leaders as they reflected on more oppressed and privileged aspects of their identity and wrestled with new understandings that acting as equity leaders would entail disrupting power dynamics and empowering others for collective learning and action.DiscussionThe results reveal the potential of developing equity-focused CI mindsets through leadership programs that intentionally integrate methods of CI with critical analysis of one’s social identity and leadership practices amid systems of oppression.
Venous thrombolysis prior to mechanical thrombectomy reduces glycocalyx damage in patients with acute ischemic stroke
Authors: Xu Bin , Yin Tengkun , Sun Tanggui , Lv Hang , Zhang Wenyv , Zan Xv , Hao Jiheng , Wang Jiyue , Zhang Liyong 
Published: August 2024

IntroductionThe administration of intravenous thrombolysis (IVT) before mechanical thrombectomy (MT) in the treatment of acute ischemic stroke (AIS) has been a subject of debate, and its potential benefits remain uncertain. This retrospective study aimed to investigate the effect of preoperative IVT on glycocalyx damage in patients with cerebral ischemia-reperfusion injury (IRI).MethodsA cohort of 106 patients with acute large vessel occlusion in the anterior circulation treated with mechanical thrombectomy was enrolled. The levels of the glycocalyx damage marker, syndecan-1, were measured in the peripheral blood of these patients to assess glycocalyx damage during IRI, and clinical outcomes were compared between patients receiving MT alone vs. combined IVT and MT.ResultsThe study results indicate that thrombolytic drugs have a significant impact on syndecan-1 levels in the blood. Compared to patients who underwent direct MT, those who received preoperative IVT had significantly lower levels of syndecan-1 in their blood. Although preoperative IVT did not alter the final clinical outcomes, the levels of syndecan-1 shedding reflect the extent of damage to the endothelial glycocalyx.DiscussionThis suggests that using thrombolytic drugs before mechanical thrombectomy may reduce endothelial glycocalyx damage in patients with ischemia-reperfusion injury. These findings provide indirect clinical evidence supporting the preoperative use of intravenous thrombolysis in such patients.
The impact of donor-specific antibodies’ presence on the outcome post-allogeneic hematopoietic stem cell transplantation: a survey from a single center
Authors: Sica Simona , Metafuni Elisabetta , Frioni Filippo , Limongiello Maria Assunta , Galli Eugenio , Sorà Federica , Bacigalupo Andrea , Poggi Elvira , Feccia Mariano Antonio , Manfreda Annarita , Chiusolo Patrizia , Giammarco Sabrina 
Published: August 2024

IntroductionDonor-specific antibodies (DSAs) correspond to anti-HLA antibodies of the recipient that are specifically directed to a mismatched antigen of the donor. In the setting of solid organ transplantation DSAs are associated with rejection. Their role is still debated in allogeneic cell transplantation. International guidelines recommend testing patients for DSA before transplant, and if possible, choosing a donor with negative screening.MethodsWe collected clinical data of 236 recipients of alloSCT, performed at our institution from March 2019 to October 2023, to evaluate their impact on engraftment. Serum from all patients was tested for DSA.Results186 patients (79%) achieved sustained myeloid engraftment within day 30 post alloSCT. Thirty-two out 236 (13%) patients engrafted after day 30 post alloSCT. The median times to neutrophil engraftment and platelet engraftment were respectively 21 days (range 11-121 days) and 19 days (range 10-203 days). Fourteen out 236 patients (6%) experienced PrGF. .Twenty-nine patients (12 %) were DSA-positive. Among 29 patients with DSA positivity, 17 had a haploidentical donor and 12 had a UD donor. DSA positivity directly correlates respectively with neutrophil and platelets engraftment failure at 30 days after alloSCT (p=0.01 and p= 0.0004). Univariate Cox analysis showed that factors, including DSAs positivity, disease type, disease status, donor type, conditioning regimen, patient's age, and CD34+ were correlated with neutrophil and platelet engraftment failure at 30 days after alloSCT. Younger patients with DSA negativity, with acute leukemia, in complete response at the time of transplant, who received a higher dose of CD34+ cells from a sibling donor after a myeloablative conditioning regimen, have a reduced risk of neutrophil and platelet engraftment failure at day +30 post alloSCT.Multivariate analysis confirmed the impact of the presence of DSA only for platelet engraftment, confirming the role of type and status disease, donor type, recipient age, and CD34+ cells infused on engraftment. DSA presence has no impact on TRM, DFS, and OS.DiscussionPrGF has a multifactorial pathogenesis, where DSA is not the only player, but its impact could vary depending on the transplant platform. Thus patient screening may be helpful to choose the best donor and transplant strategy.
The clinical outcome of minor changes in serum creatinine for patients after curative gastrectomy: a prospective study
Authors: Cai Wen-Tao , Zeng Xiu-Ya , Huang Yun-Shi , Chen Wei-Sheng , Chen Xiang-Jian , Xie Xian-Hai 
Published: August 2024

IntroductionPatients with renal insufficiency are more prone to postoperative complications (PCs). Studies have shown that minor changes in serum creatinine (SCr), immediately post-surgery, can aid in assessing patients’ renal function. This study aimed to explore the relationship between the changes in SCr and PCs in patients with gastric cancer (GC).Materials and methodsWe prospectively collected data regarding the SCr of 530 GC patients, within 2 weeks before surgery and within 24 hours after surgery in our hospital (2014–2016). The patients were divided into three groups according to the level of SCr change after surgery: reduced (&lt;10%), normal (10%), and elevated (&gt;10%) creatinine groups. Univariate and multivariate logistic analysis were performed to evaluate its correlation with short-term PCs in the patients. The R language was used to construct a nomogram.Results83, 217, and 230 patients were assigned to the elevated, reduced, and normal SCr groups, respectively. Multivariate analysis showed that the reduced and elevated SCr groups were independently associated with the occurrence of PCs and severe postoperative complications (SPCs), respectively. Additionally, postsurgical SCr change, age, hypoalbuminemia, total gastrectomy, combined resection, and laparoscopy, were independently related to PCs. Combining the above influential factors, the predictive model can distinguish patients with PCs more reliably (c-index is 0.715).ConclusionPost-surgery, reduced SCr is a protective factor for PCs, while elevated serum creatinine is an independent risk factor for SPCs. Our nomogram can identify GC patients with high risks of PCs.
The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity
Authors: Peters Godefridus J. , Kathmann Ietje , Giovannetti Elisa , Smid Kees , Assaraf Yehuda G. , Jansen Gerrit 
Published: August 2024

BackgroundL-Leucovorin (l-LV; 5-formyltetrahydrofolate, folinic acid) is a precursor for 5,10-methylenetetrahydrofolate (5,10-CH2-THF), which is important for the potentiation of the antitumor activity of 5-fluorouracil (5FU). LV is also used to rescue antifolate toxicity. LV is commonly administered as a racemic mixture of its l-LV and d-LV stereoisomers. We compared dl-LV with l-LV and investigated whether d-LV would interfere with the activity of l-LV.MethodsUsing radioactive substrates, we characterized the transport properties of l-LV and d-LV, and compared the efficacy of l-LV with d-LV to potentiate 5FU-mediated thymidylate synthase (TS) inhibition. Using proliferation assays, we investigated their potential to protect cancer cells from cytotoxicity of the antifolates methotrexate, pemetrexed (Alimta), raltitrexed (Tomudex) and pralatrexate (Folotyn).Resultsl-LV displayed an 8-fold and 3.5-fold higher substrate affinity than d-LV for the reduced folate carrier (RFC/SLC19A1) and proton coupled folate transporter (PCFT/SLC46A1), respectively. In selected colon cancer cell lines, the greatest enhanced efficacy of 5FU was observed for l-LV (2-fold) followed by the racemic mixture, whereas d-LV was ineffective. The cytotoxicity of antifolates in lymphoma and various solid tumor cell lines could be protected very efficiently by l-LV but not by d-LV. This protective effect of l-LV was dependent on cellular RFC expression as corroborated in RFC/PCFT-knockout and RFC/PCFT-transfected cells. Assessment of TS activity in situ showed that TS inhibition by 5FU could be enhanced by l-LV and dl-LV and only partially by d-LV. However, protection from inhibition by various antifolates was solely achieved by l-LV and dl-LV.ConclusionIn general l-LV acts similar to the dl-LV formulations, however disparate effects were observed when d-LV and l-LV were used in combination, conceivably by d-LV affecting (anti)folate transport and intracellular metabolism.
Patients with acute intracerebral hemorrhage and severe symptoms are highly sensitive to prehospital delay. A subgroup analysis from the RESIST and TRIAGE-STROKE trials
Authors: Behrndtz Anne , Simonsen Claus Z. , Valentin Jan B. , Andersen Grethe , Blauenfeldt Rolf A. 
Published: August 2024

BackgroundPatients with a positive prehospital stroke severity score and underlying intracerebral hemorrhage (ICH) may be harmed by longer onset-to-admission time. We aimed to investigate the interaction between ICH severity and time from onset to admission on functional outcome.MethodsThis is an individual patient data analysis with data from two randomized prehospital stroke trials using the same prehospital stroke scale. Patients were stratified according to the presence of a positive stroke severity score. They were grouped into early arrivers (admitted ≤ 90 min from onset) and late arrivers (admitted ≥90 min after onset). The primary outcome was a shift toward a better functional outcome on the modified Rankin Scale (mRS).ResultsA total of 212 patients had ICH. A positive stroke severity score was seen in 123 of these patients. Patients with ICH and a positive prehospital stroke severity score had a significantly worse outcome if they arrived 90 min or later at the hospital (adjusted odds ratio [aOR]: 2.02, 95% CI [1.01, 4.12]). This difference was not observed in patients without a positive severity score (aOR: 0.50, 95% CI [0.22, 1.14]). Patients with a positive score also had an increased risk of death or severe dependency (mRS of 5–6) of 9.1 percentage points (95% CI [−1.6%, 19.8%]) per hour if they were diagnosed with ICH.ConclusionLonger onset-to-admission time was harmful for patients with ICH and a positive prehospital stroke severity score.
Hubungan Kekerabatan Kakatua (Psittaciformes) Berdasarkan Gen Cytochrome C Oxidase Subunit I (COI) secara In-silico
Authors: Pharmawati Made , Rosiana I Wayan 
Published: August 2024

Cockatoos are member of the order Psittaciformes. Indonesia have eight endemic species of Cockatoos including : Black Palm Cockatoo (Probosciger aterrimus), Moluccan Cockatoo (Cacatua moluccensis), Tanimbar Cockatoo (Cacatua goffiniana), White Crested Cockatoo (Cacatua alba), Galerita or Triton Cockatoo (Cacatua galerita), Little Corella Cockatoo (Cacatua sanguinea ), Lesser Cockatoo (Cacatua sulphurea) and Citroon Cockatoo (Cacatua sulphurea citrinocristata). Genetic studies are currently considered an appropriate method for studying species relationships. This research aimed to determine the relationship of endemic Indonesian Cockatoos genus Cacatoa using COI gene in silico. The COI gene sequence for each individual cockatoo was accessed through National Center for Biotechnology (NCBI) data, sequence alignment and phylogenetic tree reconstruction using software mega version 11. The results of the phylogenetic tree reconstruction showed that the Indonesian endemic cockatoogenus Cacatoa were grouped into three clusters. The three clusters were the cluster of C. galerita and C. sulphurea, the cluster of C. goffiniana and C. sanguinea, and the cluster of C. alba and C. moluccensis.
FORMATION OF NATURAL PHYTOCENOSES ON THE ABANDONED PIT OF BRICK CLAY AS THE INITIAL STAGE OF FURTHER FOREST
Authors: Осипенко Регина Александровна , Осипенко Алексей Евгеньевич , Зарипов Юрий Валерьевич , Залесов Сергей Вениаминович 
Published: August 2024

Проанализировано формирование первичных сукцессий на различных элементах (дно, склоны, прилегающие территории) выработанного карьера кирпичной глины на месторождении Красноармейское II. Указанное месторождение расположено на территории округа пристепных сосново-березовых лесов Зауральской равнинной провинции Западно-Сибирской равнинной лесорастительной области.На каждом элементе карьера, спустя 3 года после завершения добычи глины закладывались трансекты, на которых располагались через равные расстояния учетные площадки размером 0,5 × 0,5 м в количестве не менее 20. На учетных площадках устанавливалось флористическое разнообразие, проективное покрытие и надземная фитомасса видов в абсолютно сухом состоянии.Исследованиями установлено, что на выработанном карьере произрастает 66 видов сосудистых растений из 22 семейств. При этом 43 вида приурочены к дну карьера, 29 видов - к склонам и 48 видов произрастают на прилегающей территории (контроль). Надземная фитомасса в абсолютно сухом состоянии на дне карьера составляет 987,6 кг/га, при аналогичном показателей на склонах и контроле 850,6 и 1430,8 кг/га. Проективное покрытие на дне, склонах и контроле составляет 56,8; 39,1 и 87,0% соответственно.Формирование первичных сукцессий на дне и склонах карьера происходит преимущественно за счет синантропных и луговых видов. Доминирующим семейством по количеству видов является Asteraceae. Между элементами карьера зафиксировано малое соответствие видов.
The paper deals with the primary successions formation of various elements (bottom, slopes, adjacent territories) of abandoned pit of brick clay of Krasnoarmeiskoye II deposit. The deposit is located on the territory of pre-steppe pine-birch forests of Zauralsk plain province (West-Siberian plain forest growing region).On each pitselement 3 years later after clay output stopping laid transects were laid on which throngheqial distances sampling quadrates of 0.5 × 0.5 m size numbering no less than 20 were located. On the sampling quadrates floristic diversity, projective covering and species elevatedbiomass in absolutely dry condition were established.It was established by studies that 66 species of vascular plants of 22 families are growing on the worked out quarry. 43 species are attached to the quarry bottom, 29 to the slopes and 48 species are growing on adjacent territories. The elevated biomass in absolutely dry condition on the quarry bottom constitutes 987.6 kg/ha in indicators analogues condition on slopes and in control - 850.6 and 1430.8 kg/ha. Projective covering on the bottom, slopes and control constitute 56.8; 39.1 and 87.0% correspondently.Primary successions formation at the bottom and slopes of the quarry takes place at the expense of synanthropic and meadow species. Asteraceae is the dominating family as concerns the number of species between the quarry elements there are fixed only slight correspondence of species.