bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient Total Synthesis and Biological Activities of 6‐Deoxyisojacareubin
Authors: Dai Ming , Yuan Xing , Zhu Zhi‐Jun , Shan Lei , Liu Run‐Hui , Sun Qing‐Yan , Zhang Wei‐Dong 
Published: March 2013

Abstract6‐Deoxyisojacareubin was directly synthesized in a six‐step route with an overall yield of about 20%. In this route, the excellent site selectivity of this Claisen rearrangement‐cyclization reaction cascade was achieved by inserting a bulky p‐tosyl group into the free 1‐OH, and in the last step, some efficient demethylation methods were explored. Furthermore, all synthesized intermediates including 6‐deoxyisojacareubin were evaluated for their inhibitory activity against the QGY‐7703 cell line. Of these, compound 1 and 6‐deoxyisojacareubin showed moderate activities with IC50 values of 39.61 and 9.65 µM, respectively, when compared to the positive control 5‐fluorouracil with an IC50 value of 11.24 µM. Further investigation using non‐radioactive detection of protein kinase C (PKC) suggested that these two compounds possessed potency in the inhibition of PKC.
Are all regions of folded proteins that undergo ligand‐dependent order–disorder transitions targets for allosteric peptide mimetics?
Authors: Fenton Aron W. 
Published: March 2013

ABSTRACTAlthough the classical view of how proteins function relied on well folded structures, it is now recognized that the functions of many proteins are dependent on being intrinsically disordered. The primary consideration in this work is the intermediate group of proteins that are overall well folded, but which contain small regions that undergo order–disorder transitions. In particular, the current focus is on those order–disorder transitions that are energetically coupled to ligand binding. As exemplified by the case of human liver pyruvate kinase (hL‐PYK), peptides that mimic the sequence of the order–disorder region can be used as allosteric regulators of the enzyme. On the basis of this example and others reported in the literature, we propose that a similar use of peptides that mimic protein regions that experience ligand‐dependent order–disorder transitions can be a generalized initiation point for the development of allosteric drugs. © 2013 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 100: 553–557, 2013.
Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1‐mediated gene expression in vivo
Authors: Willis Monte S. , Wadosky Kristine M. , Rodríguez Jessica E. , Schisler Jonathan C. , Lockyer Pamela , Hilliard Eleanor G. , Glass David J. , Patterson Cam 
Published: March 2013

AimsMuscle ring finger (MuRF) proteins have been implicated in the transmission of mechanical forces to nuclear cell signaling pathways through their association with the sarcomere. We recently reported that MuRF1, but not MuRF2, regulates pathologic cardiac hypertrophy in vivo. This was surprising given that MuRF1 and MuRF2 interact with each other and many of the same sarcomeric proteins experimentally.Methods and ResultsMice missing all four MuRF1 and MuRF2 alleles [MuRF1/MuRF2 double null (DN)] were born with a massive spontaneous hypertrophic cardiomyopathy and heart failure; mice that were null for one of the genes but heterozygous for the other (i.e. MuRF1−/−//MuRF2+/− or MuRF1+/−//MuRF2−/−) were phenotypically identical to wild‐type mice. Microarray analysis of genes differentially‐expressed between MuRF1/MuRF2 DN, mice missing three of the four alleles and wild‐type mice revealed a significant enrichment of genes regulated by the E2F transcription factor family. More than 85% of the differentially‐expressed genes had E2F promoter regions (E2f:DP; P < 0.001). Western analysis of E2F revealed no differences between MuRF1/MuRF2 DN hearts and wild‐type hearts; however, chromatin immunoprecipitation studies revealed that MuRF1/MuRF2 DN hearts had significantly less binding of E2F1 in the promoter regions of genes previously defined to be regulated by E2F1 (p21, Brip1 and PDK4, P < 0.01).ConclusionsThese studies suggest that MuRF1 and MuRF2 play a redundant role in regulating developmental physiologic hypertrophy, by regulating E2F transcription factors essential for normal cardiac development by supporting E2F localization to the nucleus, but not through a process that degrades the transcription factor. Copyright © 2013 John Wiley & Sons, Ltd.
Post‐Synthetic Monovalent Central‐Metal Exchange, Specific I2 Sensing, and Polymerization of a Catalytic [3×3] Grid of [CuII5CuI4L6]⋅(I)2⋅13 H2O
Authors: Han Yi , Chilton Nicholas F. , Li Ming , Huang Chao , Xu Hong , Hou Hongwei , Moubaraki Boujemaa , Langley Stuart K. , Batten Stuart R. , Fan Yaoting , Murray Keith S. 
Published: March 2013

AbstractFrom a predesigned grid, [CuII5CuI4L6]⋅(I)2⋅13 H2O (1), in which LH2 was a pyrazinyl‐triazolyl‐2,6‐substituted pyridine, we successfully synthesized an extended 3D complex, 1∞[{CuII5CuI8L6}{μ‐[CuI3(CN)6]}2⋅2 CH3‐ CN] (2), that displayed unprecedented coexistence of all the five known coordination geometries of copper. Grid 1 displayed monovalent central metal exchange (CME) of CuI for AgI for the first time, as well as the formation of tri‐iodide in the crystalline state. These systems were investigated for their magnetic properties. Remarkably, grid 1 showed much higher catalytic activity than the Ag‐exchanged product for synthesis of a substituted triazole, 1‐benzyl‐4‐phenyl‐1H‐1,2,3‐triazole.
A Continuous‐Flow Process for the Synthesis of Artemisinin
Authors: Kopetzki Daniel , Lévesque François , Seeberger Peter H. 
Published: March 2013

AbstractIsolation of the most effective antimalarial drug, artemisinin, from the plant sweet wormwood, does not yield sufficient quantities to provide the more than 300 million treatments needed each year. The high prices for the drug are a consequence of the unreliable and often insufficient supply of artemisinin. Large quantities of ineffective fake drugs find a market in Africa. Semisynthesis of artemisinin from inactive biological precursors, either dihydroartemisinic acid (DHAA) or artemisinic acid, offers a potentially attractive route to increase artemisinin production. Conversion of the plant waste product, DHAA, into artemisinin requires use of photochemically generated singlet oxygen at large scale. We met this challenge by developing a one‐pot photochemical continuous‐flow process for the semisynthesis of artemisinin from DHAA that yields 65 % product. Careful optimization resulted in a process characterized by short residence times. A method to extract DHAA from the mother liquor accumulated during commercial artemisinin extractions, a material that is currently discarded as waste, is also reported. The synthetic continuous‐flow process described here is an effective means to supplement the limited availability of artemisinin and ensure increased supplies of the drug for those in need.
ChemInform Abstract: Pressure‐Induced Valence and Structural Changes in YbMn2Ge2—Inelastic X‐Ray Spectroscopy and Theoretical Investigations.
Authors: Kumar Ravhi S. , et al. et al. 
Published: March 2013

AbstractPressure induced changes in the electronic structure of the title compound are investigated using high pressure XRD, resonant X‐ray emission spectroscopy, and X‐ray absorption spectroscopy in the partial fluorescence yield mode for pressures from ambient to 40 GPa.
ChemInform Abstract: Synthesis and Properties of Multifunctional Tetragonal Eu:GdPO4 Nanocubes for Optical and Magnetic Resonance Imaging Applications.
Authors: Rodriguez‐Liviano Sonia , Becerro Ana I. , Alcantara David , Grazu Valeria , de la Fuente Jesus M. , Ocana Manuel 
Published: March 2013

AbstractThe title nanocubes are prepared by microwave‐assisted heating of Gd(acac)3, Eu(acac)3, and H3PO4 dissolved in butylene glycol (microwaves, autoclave, 120 °C, 1 h).
ChemInform Abstract: High Magnetic Moments in Manganese‐Doped Silicon Clusters.
Authors: Ngan Vu Thi , Janssens Ewald , Claes Pieterjan , Lyon Jonathan T. , Fielicke Andre , Nguyen Minh Tho , Lievens Peter 
Published: March 2013

AbstractManganese‐doped silicon clusters SinMn+ (n = 6—10, 12—14, 16) are characterized by IR multiple photon dissociation spectroscopy and DFT calculations.
ChemInform Abstract: Gibbs Energies of Formation of the Intermetallic Compounds of U—Sn System.
Authors: Pattanaik Ashit K. , Kandan R. , Nagarajan K. , Rao P. R. Vasudeva 
Published: March 2013

AbstractGibbs energies of formation of USn3, U3Sn7, USn2, and USn are determined using high temperature molten salt galvanic cells, U(s)//UCl3 in LiCl—KCl (eutectic)//U—Sn alloy.
ChemInform Abstract: Si/Mesoporous Carbon Composite as an Anode Material for Lithium Ion Batteries.
Authors: Shen Xueyang , Mu Daobin , Chen Shi , Xu Bin , Wu Borong , Wu Feng 
Published: March 2013

AbstractSi/mesoporous carbon composite is prepared from a mixture of SiO2 powder, Mg powder, and mesoporous carbon heated in a tube furnace at 650 °C for 6 h under Ar.
ChemInform Abstract: Catalytic Oxidation of Soot over Alkaline Niobates.
Authors: Pecchi G. , Cabrera B. , Buljan A. , Delgado E. J. , Gordon A. L. , Jimenez R. 
Published: March 2013

AbstractMNbO3 powders (M: Li, Na, K, Rb) are synthesized by a citrate method and calcined at 450, 550, 650, and 750 °C.
ChemInform Abstract: Synthesis, Computed Stability, and Crystal Structure of a New Family of Inorganic Compounds: Carbonophosphates.
Authors: Chen Hailong , Hautier Geoffroy , Ceder Gerbrand 
Published: March 2013

AbstractThe carbonophosphates Na3M(PO4)(CO3) (M: Mg, Sr, Mn, Fe, Co, Ni, Cu) are hydrothermally synthesized.
ChemInform Abstract: The Unprecedented Tetrakis‐(disulfato)‐silicate Anion [Si(S2O7)4]4‐, Its Germanium Congener [Ge(S2O7)4]4‐, and the Tris‐(disulfato)‐metallates [M(S2O7)3]2‐ (M: Si, Ge, Ti), Stabilized by Divalent Counter Cations B2+ (B: Sr, Ba, Pb).
Authors: Logemann Christian , Riess Katja , Wickleder Mathias S. 
Published: March 2013

AbstractThe compounds Sr2[M(S2O7)4] (M: Si, Ge), Ba[M(S2O7)3] (M: Si, Ge, Ti), and Pb[M(S2O7)3] (M: Ge, Ti) are prepared by reaction of MCl4 (M: Si, Ge, Ti) and BX (B: Sr, Ba, Pb; X: CO3, SO4) with oleum (sealed glass ampules, 100—250 °C, 12—14 h).
ChemInform Abstract: Amidation of Aldehydes and Alcohols Through α‐Iminonitriles and a Sequential Oxidative Three‐Component Strecker Reaction/Thio‐Michael Addition/Alumina‐Promoted Hydrolysis Process to Access β‐Mercaptoamides from Aldehydes, Amines, and Thiols.
Authors: Gualtierotti Jean‐Baptiste , Schumacher Xavier , Fontaine Patrice , Masson Geraldine , Wang Qian , Zhu Jieping 
Published: March 2013

AbstractMicrowave‐assisted amidation of aldehydes with amines is not applicable to aromatic aldehydes because products decompose under conditions used.
ChemInform Abstract: Silver‐Catalyzed Direct Addition of Terminal Alkynes to Simple Cyclic Ketones in Water.
Authors: Jia Zhenhua , Li Xingshu , Chan Albert S. C. , Li Chao‐Jun 
Published: March 2013

AbstractUnder conditions A), cyclohexane (Ia) and some derivatives (no stereochemistries indicated) can be easily transformed to propargyl alcohol systems.
ChemInform Abstract: Regioselective Cross‐Coupling of Allylboronic Acid Pinacol Ester Derivatives with Aryl Halides via Pd‐PEPPSI‐IPent.
Authors: Farmer Jennifer L. , Hunter Howard N. , Organ Michael G. 
Published: March 2013

AbstractThis highly reliable protocol for selective α‐allylation of aromatic halides relies on the utilization of the sterically bulky catalyst PPI.
ChemInform Abstract: Copper‐ and Phosphine‐Ligand‐Free Palladium‐Catalyzed Direct Allylation of Electron‐Deficient Polyfluoroarenes with Allylic Chlorides.
Authors: Yu Yan‐Bo , Fan Shilu , Zhang Xingang 
Published: March 2013

AbstractThe presented direct allylation with allylic chlorides is applicable to various electron‐deficient polyfluoroarenes and works even with so‐called ′inert′ polyfluoroarenes like (XIII).
ChemInform Abstract: Organocatalytic, Oxidative, Intermolecular Amination and Hydrazination of Simple Arenes at Ambient Temperature.
Authors: Samanta Rajarshi , Bauer Jonathan O. , Strohmann Carsten , Antonchick Andrey P. 
Published: March 2013

AbstractA new, mild, efficient, and environmentally friendly method renders possible the preparation of anilines and aromatic hydrazines from non‐prefunctionalized arenes.
ChemInform Abstract: Palladium‐Mediated Heck‐Type Reactions of [(Bromodifluoromethyl)sulfonyl]benzene: Synthesis of α‐Alkenyl‐ and α‐Heteroaryl‐Substituted α,α‐Difluoromethyl Phenyl Sulfones.
Authors: Surapanich Nakin , Kuhakarn Chutima , Pohmakotr Manat , Reutrakul Vichai 
Published: March 2013

AbstractFor the first time the palladium‐mediated oxidative addition of the (phenylsulfonyl)difluoromethylene group to olefins is presented.
ChemInform Abstract: Direct Pd‐Catalyzed Cross‐Coupling of Functionalized Organoaluminum Reagents.
Authors: Groll Klaus , Bluemke Tobias D. , Unsinn Andreas , Haas Diana , Knochel Paul 
Published: March 2013

AbstractA broad spectrum of aromatic or benzylic aluminum reagents, generated in situ from different types of substrates is demonstrated to give the expected products.
ChemInform Abstract: Stereospecific Cross‐Coupling of Secondary Organotrifluoroborates: Potassium 1‐(Benzyloxy)alkyltrifluoroborates.
Authors: Molander Gary A. , Wisniewski Steven R. 
Published: March 2013

AbstractA method for the direct installation of a secondary alcohol through a Suzuki—Miyaura reaction (after deprotection) is developed.
ChemInform Abstract: Stereoselective Intramolecular Carbene C—H Insertion Catalyzed by Rhodium(III) Porphyrin Complexes.
Authors: Lo Vanessa Kar‐Yan , Thu Hung‐Yat , Chan Yu‐Man , Lam Tsz‐Lung , Yu Wing‐Yiu , Che Chi‐Ming 
Published: March 2013

AbstractAmong some Rh(III)‐porphyrin complexes tested, (I) is found to be the most efficient catalyst for the intramolecular carbene C—H insertion of α‐diazoacetamides to form β‐ or γ‐lactams with high diastereoselectivity.
ChemInform Abstract: Copper(I)‐Catalyzed Enantioselective Incorporation of Ketones to Cyclic Hemiaminals for the Synthesis of Versatile Alkaloid Precursors.
Authors: Shi Shi‐Liang , Wei Xiao‐Feng , Shimizu Yohei , Kanai Motomu 
Published: March 2013

AbstractThe first general catalytic enantioselective procedure for introducing various ketones to N‐heterocycles with differing ring sizes is developed from stable and easily available cyclic hemiaminals and ketones.
ChemInform Abstract: Highly Diastereoselective 1,3‐Dipolar Cycloaddition via in situ Formed Ketimine Ylides.
Authors: Cheng Yu , Liu Ya‐Nan , Ye Jia , He Long , Kang Tai‐Ran , Liu Quan‐Zhong 
Published: March 2013

AbstractReaction of unsaturated keto esters with glycine derivative (II) is investigated with a view to obtaining the corresponding Michael adducts.
ChemInform Abstract: Direct Conversion of Indoles to 3,3‐Difluoro‐2‐oxindoles via Electrophilic Fluorination.
Authors: Lim Yee Hwee , Ong Qunxiang , Duong Hung A. , Nguyen Tuan Minh , Johannes Charles W. 
Published: March 2013

AbstractThe presence of tert‐butyl hydroperoxide and the final heating with triethylamine are crucial for high yields.
ChemInform Abstract: Desulfurization—Oxygenation of Chiral 1,3‐Thiazolidine‐2‐thiones and 1,3‐Oxazolidine‐2‐thiones Using Propylene Oxide and Microwave Irradiation.
Authors: Minor‐Villar Leticia , Tello‐Aburto Rodolfo , Olivo Horacio F. , Fuentes Aydee , Romero‐Ortega Moises 
Published: March 2013

AbstractThe sequence can be performed under conventional heating and microwave irradiation to produce the target compounds, which are required as chiral auxiliaries or, such as example (IV), additionally as antibiotic agents.
ChemInform Abstract: Copper‐Catalyzed Huisgen and Oxidative Huisgen Coupling Reactions Controlled by Polysiloxane‐Supported Amines (AFPs) for the Divergent Synthesis of Triazoles and Bistriazoles.
Authors: Zheng Zhan‐Jiang , Ye Fei , Zheng Long‐Sheng , Yang Ke‐Fang , Lai Guo‐Qiao , Xu Li‐Wen 
Published: March 2013

AbstractDepending on the ligand used, this method yields either bistriazoles via an oxidative Huisgen coupling reaction or triazoles via a classic Huisgen reaction.
ChemInform Abstract: A Short Asymmetric Synthesis of the Benzopyrano[3,4‐c]pyrrolidine Core via an Organocatalytic Domino Oxa‐Michael/Michael Reaction.
Authors: Wang Chuan , Yang Xuena , Raabe Gerhard , Enders Dieter 
Published: March 2013

AbstractAn asymmetric synthesis of 3,4‐trans‐disubstituted chromans (III) employing nitrovinylphenols (I) and acrolein (II) as precursors is described.
ChemInform Abstract: A Greener Synthesis of 1,8‐Dioxo‐octahydroxanthene Derivatives under Ultrasound.
Authors: Mulakayala Naveen , Kumar G. Pavan , Rambabu D. , Aeluri Madhu , Rao M. V. Basaveswara , Pal Manojit 
Published: March 2013

AbstractCAN is described as efficient catalyst under the optimized conditions which avoid the use of harmful solvents such as the chlorinated ones.
ChemInform Abstract: Highly Regio‐, Diastereo‐ and Enantioselective One‐Pot Gold/Chiral Broensted Acid‐Catalyzed Cascade Synthesis of Bioactive Diversely Substituted Tetrahydroquinolines.
Authors: Liu Xin‐Yuan , Xiao Ya‐Ping , Siu Fung‐Ming , Ni Li‐Chen , Chen Yong , Wang Lin , Che Chi‐Ming 
Published: March 2013

AbstractThis provides access to tetrahydroquinolines possessing one or two stereocenters at different positions as well as highly divergent functional groups.
ChemInform Abstract: Phosphane‐Catalyzed [4 + 2] Annulation of Allenoates with Ketimines: Synthesis of Sultam‐Fused Tetrahydropyridines.
Authors: Chen Xiang‐Yu , Ye Song 
Published: March 2013

AbstractThe synthesis of functionalized tetrahydropyridines in good yield with moderate to excellent regioselectivity via cycloaddition of allenoates and ketimines is described.
ChemInform Abstract: Silver Triflate‐Catalyzed Tandem Reaction of N′‐(2‐Alkynylbenzylidene)hydrazide with Pyridyne.
Authors: Jiang Lingyong , Yu Xingxin , Fang Bing , Wu Jie 
Published: March 2013

AbstractThe reaction of (alkynylbenzylidene)hydrazines (I), bearing either alkyl or phenyl substituents on the triple bond, with pyridine derivative (II) works well to produce the pyridine‐fused pyrazoloisoquinolines in good yields, although the transformations occur not regioselectively.
ChemInform Abstract: Asymmetric Synthesis of Ring‐Fused Tetrahydroquinolines Using Organocatalytic Enantioselective Conjugate Addition and Cross‐Dehydrogenative Coupling.
Authors: Gwon Sung Hyuk , Kim Sung‐Gon 
Published: March 2013

AbstractEnantioenriched ring‐fused tetrahydroquinolines (IV) are synthesized via enantioselective conjugate addition of malonates (II) to 2‐N‐tetrahydroisoquinolinyl‐substituted cinnamaldehyde (I), followed by intramolecular cross‐dehydrogenative coupling.
ChemInform Abstract: Multitargeted Drug Development: Discovery and Profiling of Dihydroxy Substituted 1‐Aza‐9‐oxafluorenes as Lead Compounds Targeting Alzheimer Disease Relevant Kinases.
Authors: Tell Volkmar , Holzer Max , Herrmann Lydia , Mahmoud Kazem Ahmed , Schaechtele Christoph , Totzke Frank , Hilgeroth Andreas 
Published: March 2013

AbstractTwo new nanomolar active CDK1, CDK5/p25 and GSK‐3β inhibitors of the 3,6‐dihydroxy‐1‐aza‐9‐oxafluorene type (IV) are discovered.
ChemInform Abstract: Intramolecular Schmidt Reaction of Acyl Chlorides with Alkyl Azides: Rapid Access to Fused Polycyclic Nitrogen‐Containing Heterocycles via a Multistep One‐Pot Transformation.
Authors: Gu Peiming , Kang Xiao‐Yan , Sun Jian , Wang Bao‐Juan , Yi Ming , Li Xue‐Qiang , Xue Ping , Li Rui 
Published: March 2013

AbstractThe three‐step one‐pot reaction proceeds via acyl chlorination followed by a Schmidt reaction of the acyl chloride and concluding electrophilic intramolecular addition of the isocyanate ion to the aromatic ring.
ChemInform Abstract: A New Practical and Highly Efficient Iodination of BODIPY Derivatives with Hypervalent Iodine Reagent.
Authors: Ye Jia‐Hai , Hu Zhengjuan , Wang Yixin , Zhang Whenchao , Zhang Yan 
Published: March 2013

AbstractOptimal conditions are developed for bis‐ and mono‐iodination of substrates (I) in order to get modified structures of the chemically important boron scaffold.
ChemInform Abstract: Template‐Free Fabrication of Bi2O3 and (BiO)2CO3 Nanotubes and Their Application in Water Treatment.
Authors: Qin Fan , Li Guangfang , Wang Runming , Wu Jiliang , Sun Hongzhe , Chen Rong 
Published: March 2013

AbstractBi2O3 and (BiO)2CO3 nanotubes are solvothermally synthesized from Bi(NO3)3 and urea in ethylene glycol (autoclave, 150 °C, 12 h).
Exhaust Gas Aftertreatment in Mobile Systems: Status, Challenges, and Perspectives
Authors: Deutschmann Olaf , Grunwaldt Jan‐Dierk 
Published: March 2013

AbstractEine ganzheitliche Betrachtungsweise von Abgasnachbehandlungssystemen ist derzeit der attraktivste Ansatzpunkt für die weitere Verminderung der Schadstoffemissionen und um auf neue Herausforderungen durch strengere Emissionsgrenzwerte, neue Rohstoffbasis und effektivere Motorkonzepte schneller zu reagieren. Dieser Artikel gibt einen Überblick zu gegenwärtigen Abgasnachbehandlungssystemen. Heutige und zukünftige Herausforderungen und Ansätze zu deren Bewältigung werden diskutiert. Bei den vorgestellten Lösungsansätzen spielen hierarchische Modellierung von DFT‐Berechnungen bis zur CFD‐Simulation des kompletten Abgasstranges, realitätsnahe Abgasprüfstände und Alterungsverfahren sowie On‐board‐Diagnostik ebenso wie die Charakterisierung von Katalysatoren insbesondere unter Reaktionsbedingungen sowie möglichst alle Längenskalen eine wichtige Rolle. In Zukunft werden wissensbasierte roboter‐kontrollierte Präparation und dynamische Modelle, gekoppelt mit Informationen aus dem realen Betrieb, Forschung und Entwicklung maßgeblich unterstützen.
Specific Transport of Target Molecules by Motor Proteins in Microfluidic Channels
Authors: Tarhan Mehmet C. , Yokokawa Ryuji , Morin Fabrice O. , Fujita Hiroyuki 
Published: March 2013

AbstractDirect transport powered by motor proteins can alleviate the challenges presented by miniaturization of microfluidic systems. There have been several recent attempts to build motor‐protein‐driven transport systems based on simple capturing or transport mechanisms. However, to achieve a multifunctional device for practical applications, a more complex sorting/transport system should be realized. Herein, the proof of concept of a sorting device employing selective capture of distinct target molecules and transport of the sorted molecules to different predefined directions is presented. By combining the bottom‐up functionality of biological systems with the top‐down handling capabilities of micro‐electromechanical systems technology, highly selective molecular recognition and motor‐protein‐based transport is integrated in a microfluidic channel network.