bluuebunny/crossref_metadata_2025_split huggingface dataset:
Albumin Levels before Therapy and Clinicopathological Parameters of Lung Cancer Patients
Authors: Erna Kusumawardhani  , Nor Fiayanti Hadiani  
Published: February 2025

Highlights

A notable finding was the significant relationship between albumin levels and ECOG scores, emphasizing the potential of albumin as an indicator of functional status in lung cancer patients.
The research provided a comprehensive analysis of the correlation between albumin levels and various clinicopathological conditions.

Background: Serum albumin levels provide an objective measure of malnutrition. Albumin plays crucial roles in maintaining intravascular oncotic pressure, facilitating substance transport, and acting as a free radical scavenger. The progression of tumors, including lung cancer, is closely associated with malnutrition and cancer-related inflammation, which suppress albumin synthesis. Therefore, albumin can serve as a biomarker for assessing lung cancer progression. Low albumin levels are linked to poor prognosis. Objective: The aim of this study was to examine the relationship between albumin levels and lung cancer. Material and Method: This study included 130 lung cancer patients who underwent albumin testing. A cross-sectional study was conducted using medical records of patients diagnosed with lung cancer from January 2023 to December 2023. Data were collected on various factors, including age, gender, smoking status, cancer history, clinical symptoms, histopathological type, cancer stage, EGFR mutation status, ECOG score, clinical pleural effusion, Visual Analog Scale (VAS), and Body Mass Index (BMI). Result: The study sample was predominantly male (71.5%), aged over 50 years (76.9%), and active smokers (34.6%). Common symptoms included cough (83.8%) and shortness of breath (72.3%), with pleural effusion present in 53.8%. The majority had a moderate VAS score (46.9%) and were classified as underweight based on BMI (54.6%). Most patients were at stage IVA (63.0%), had an ECOG score of 1 (43.8%), and were diagnosed with adenocarcinoma (73.8%). A significant relationship was found between ECOG scores and albumin levels, with 70.6% of hypoalbuminemic samples having an ECOG score of 3 (p < 0.005). Conclusion: A significant relationship was observed between albumin levels and ECOG scores in lung cancer patients.
Analisis Penentuan Harga Pokok Produksi Pada Usaha Kebab Yasmin Kota Banjarmasin
Authors: Amelia Amelia , Budiwati Nina , Ferrianta Yudi 
Published: February 2025

Persaingan yang ketat pada dunia usaha menuntut perusahaan maupun UMKM untuk meningkatkan efisiensi dalam menghitung biaya produksi karena harga pokok produksi merupakan dasar bagi perusahaan untuk menentukan harga jual produknya degan tepat agar menghasilkan keuntungan yang optimal. Penelitian ini bertujuan untuk menganalisis biaya produksi dan bagaimana cara penentuan harga pokok produksi, menganalisis penerimaan dan keuntungan, serta mengidentifikasi permasalahan dan memberikan solusi pada usaha usaha Kebab Yasmin Kota Banjarbaru. Metode penelitian yang digunakan adalah metode studi kasus yaitu produsen Kebab Yasmin. Analisis data menggunakan metode garis lurus dan metode full costing yang memperhitungkan semua unsur biaya produksi seperti biaya bahan baku, biaya tenaga kerja dan biaya overhead pabrik. Hasil penelitian menunjukkan biaya produksi pada usaha Kebab Yasmin selama bulan Agustus 2024 sebesar Rp 27.502.066 dan harga pokok produksi sebesar Rp 55.181.517, penerimaan pada usaha Kebab Yasmin selama bulan Agustus 2024 sebesar Rp 55.828.000 dan keuntungan yang diperoleh sebesar Rp 24.325.934 dan permasalahan pada usaha Kebab Yasmin meliputi permasalahan dari segi bahan baku, tenaga kerja, marketing pemasaran maupun pengelompokkan biaya.
Analisis Pemasaran Pepaya di Desa Sambangan Kecamatan Bati-Bati Kabupaten Tanah Laut Kalimantan Selatan
Authors: Rajagukguk Rospanen , Anjardiani Luki , Azis Yusuf 
Published: February 2025

Penelitian ini bertujuan untuk menganalisis saluran pemasaran, biaya, margin dan keuntungan yang terkait. Penelitian dilakukan di Desa Sambangan, Kecamatan Bati-Bati, Kabupaten Tanah Laut, Kalimantan Selatan, pada periode Agustus hingga Oktober 2024. Lokasi penelitian dipilih secara purposive. Metode pengambilan sampel petani menggunakan rumus slovin yaitu dari total 39 petani diambil 15 orang. Pedagang pengumpul dan pengecer dipilih dengan metode snowball sampling. Hasil penelitian menunjukkan terdapat dua saluran pemasaran yang berbeda. Pada saluran I pemasaran pepaya, total biaya pemasaran yang dikeluarkan oleh pedagang pengecer yaitu Rp1.445,8 per kg dengan margin Rp7.500 per kg dan keuntungan yang diperoleh Rp6.054,2 per kg dan share terbesar yaitu pada tingkat pedagang pengecer sebesar 68%. Pada saluran II total biaya pemasaran yang dikeluarkan oleh pedagang pengumpul adalah Rp682,43 per kg, dengan margin Rp3.033,3 per kg dan keuntungan yang diperoleh sebesar Rp2.350,87 per kg sedangkan pada tingkat pedagang pengecer total biaya pemasaran yang dikeluarkan adalah Rp1.362,09 per kg, dengan margin Rp5.250 per kg dan keuntungan yang diperoleh adalah Rp3.887,91 per kg. Share terbesar yaitu pada tingkat pedagang pengecer sebesar 45%. Permasalahan yang dihadapi oleh petani atau produsen yaitu petani tidak memiliki informasi mengenai harga pasar. Permasalahan yang dihadapi pedagang pengumpul yaitu kualitas pepaya dan kerusakan buah selama proses pengangkutan. Permasalahan yang dihadapi oleh pedagang pengecer adalah banyak pedagang lain yang menjual pepaya dengan harga yang kompetitif.
Presentación
Authors: Montesinos Padilla Carmen 
Published: February 2025

Presentación del número 23 de la Revista Docencia y Derecho. Monográfico coordinado por Carmen Montesinos Padilla, Letrada del Tribunal Constitucional de España y Profesora de Derecho Constitucional, reflejo de la sesión del grupo de innovación docente de la Asociación de Constitucionalistas de España celebrada el pasado 7 de marzo de 2024.
Isolating the Primary Drivers of Fire Risk to Structures in WUI regions in California
Authors: Gollner Michael , Zamanialaei Maryam , Martin Daniel San , Theodori Maria , Purnomo Dwi , Tohidi Ali , Lautenberger Chris , Trouve Arnaud , Qin Yiren 
Published: February 2025

Abstract

The destructive impacts of Wildland-Urban Interface (WUI) fires on people, property and the environment have dramatically increased, especially in California. Critical factors influencing structure protection during wildfires, including home hardening (e.g., vents, siding, roof, eaves, window, construction year), defensible space (vegetation and surrounding features), exposure to flames and embers, and structure separation are well known but their interrelated impacts are not quantified. Here, we find that structure separation and exposure significantly influence the probability of loss, underscoring the role of large conflagrations in driving widespread destruction. Machine learning models combined with previously unavailable exposure data enhance the predictive accuracy of structure loss up to 82%. Home hardening and defensible space, especially closest to the home, are still vital and effective mitigation measures, cutting hypothetical structures losses by 52%. Our results offer data-driven actionable insights for prioritizing mitigation strategies to protect vulnerable communities and structures in the WUI.
Genetically Predicted Calorie Dietary Preference as a Causal Risk Factor for Multiple Cancer Types: Evidence from Mendelian Randomization
Authors: Zhang Kaiyuan , Lou Jiaheng , Huang Jianbo , Ni Xiaochen , Wang Chuhang , Guo Jianing , Fan Wei , Lv Ailin , Zhang Guangji , Jiang Tao 
Published: February 2025

Abstract

Background
There is evidence that diet and nutrition are modifiable risk factors for several cancers. however, the causal impact of dietary calorie preference on cancer development remains uncertain.
Methods
In this study, data on dietary calorie preference were sourced from a large-scale genome-wide association study (GWAS) database of food liking, while information on 18 cancer types was obtained from Finger R9 database. Two-sample Mendelian randomization (MR) analysis was conducted to assess the causal effects of Calorie Dietary Liking on 18 types of cancers. The inverse variance weighting (IVW) method was the primary analytical approach, with significant correlations further examined using Egger regression, MR-PRESSO, and weighted median methods.
Results
Our analyses revealed that a genetically predicted preference for high-calorie diets significantly raised the risk of non-Hodgkin lymphoma (NHL) (OR = 1.75, P = 0.006), non-small cell lung cancer (NSCLC) (OR = 1.39, P = 0.001), hepatocellular carcinoma (HCC) (OR = 2.06, P = 0.025), and gastric cancer (GC) (OR = 1.47, P = 0.012). Further subgroup analyses confirmed that high-calorie foods, particularly cheese liking, were strongly linked to an elevated HCC risk (OR = 2.43, P = 0.000), while deep-fried food liking were associated with increased NSCLC risk (OR = 1.26, P = 0.005). Low-calorie dietary liking showed causal association with the risk of prostate cancer (PCa) (OR = 0.85, P = 0.013).
Conclusion
This comprehensive MR analysis suggested that genetically predicted high-calorie food liking, as well as its subgroups, may be a risk factor in the development of NHL, NSCLC, HCC, and GC. A low-calorie diet may have a protective effect on the risk of PCa.
Targeted Chemoproteomics Identifies COEAE6G Esterase Driving Insecticide Cross-
Resistance in African Malaria Vector
Authors: Ismail Hanafy , Balaska Sofia , Grigoraki Linda , Lycett Gareth , Weetman David , Oladepo Folasade , Colman Fraser , Vontas John , Paine Mark 
Published: February 2025

Abstract

Pyrethroid insecticide resistance in the primary malaria vector, Anopheles gambiae, poses a
substantial challenge to ongoing control efforts in sub-Saharan Africa, where most malaria cases
and deaths occur. To combat this challenge, newer chemicals, including pirimiphos-methyl (PM)
are being used. To gain insight into how future resistance may develop to these compounds, a
proactive chemical proteomics approach was developed using activity-based protein profiling
(ABPP) in susceptible An. gambiae to identify enzymes interacting with pirimiphos-methyl (PM)
and its toxic metabolite PMO. We discovered 18 serine hydrolases (SHs) as primary targets of
PMO, including the carboxylesterase COEAE6G. Subsequent in vitro and in vivo validation
confirmed that COEAE6G confers resistance to PM, as well as cross-resistance to malathion,
permethrin and bendiocarb. This study underscores the utility of ABPP as a powerful tool for early
detection of potential resistance markers, such as COEAE6G, enabling the development of
effective resistance management strategies.
A Quantitative Approach to Mapping Mitochondrial Specialization and Plasticity
Authors: Picard Martin , Monzel Anna , Devine Jack , Kapri Darshana , Enriquez Jose , Trumpff Caroline 
Published: February 2025

Abstract

Mitochondria are a diverse family of organelles that specialize to accomplish complimentary functions 1-3. All mitochondria share general features, but not all mitochondria are created equal 4.Here we develop a quantitative pipeline to define the degree of molecular specialization among different mitochondrial phenotypes – or mitotypes. By distilling hundreds of validated mitochondrial genes/proteins into 149 biologically interpretable MitoPathway scores (MitoCarta 3.0 5) the simple mitotyping pipeline allows investigators to quantify and interpret mitochondrial diversity and plasticity from transcriptomics or proteomics data across a variety of natural and experimental contexts. We show that mouse and human multi-organ mitotypes segregate along two main axes of mitochondrial specialization, contrasting anabolic (liver) and catabolic (brain) tissues. In cultured primary human fibroblasts exhibiting robust time-dependent and treatment-induced metabolic plasticity 6-8, we demonstrate how the mitotype of a given cell type recalibrates i) over time in parallel with hallmarks of aging, and ii) in response to genetic, pharmacological, and metabolic perturbations. Investigators can now use MitotypeExplorer.org and the associated code to visualize, quantify and interpret the multivariate space of mitochondrial biology.
Remodeling of extracellular matrix collagen IV by MIG-6/papilin regulates neuronal architecture
Authors: Bénard Claire , Nadour Malika , LEATIS Robert VALETTE REVENO , BIARD Marie , Frébault Noémie , Rivollet Lise , ST-LOUIS Philippe , BLANCHETTE Cassandra R. BLANCHETTE , THACKERAY Andrea , PERRAT Paola , Bevilacqua Carlo , Prevedel Robert , Cappadocia Laurent , Rapti Georgia , Doitsidou Maria 
Published: February 2025

Abstract

Neuronal architecture established embryonically must persist lifelong to ensure normal brain function. However, little is understood about the mechanisms behind the long-term maintenance of neuronal organization. To uncover maintenance mechanisms, we performed a suppressor screen in sax-7/L1CAM mutants, which exhibit progressive disorganization with age. We identified the conserved extracellular matrix protein MIG-6/papilin as a key regulator of neuronal maintenance. Combining incisive molecular genetics, structural predictions, in vivo quantitative imaging, and cutting-edge Brillouin microscopy, we show that MIG-6/papilin remodels extracellular matrix collagen IV, working in concert with the secreted enzymes MIG-17/ADAMTS and PXN-2/peroxidasin. This remodeling impacts tissue biomechanics and ensures neuronal stability, even under increased mechanical stress. Our findings highlight an extracellular mechanism by which MIG-6/papilin supports the integrity of neuronal architecture throughout life. This work provides critical insights into the molecular basis of sustaining neuronal architecture and offers a foundation for understanding age-related and neurodegenerative disorders.
PNIPAM-Based Hydrogel-loaded Dicliptera Chinensis Polysaccharides -treated ADSC- derived exosomes promotes angiogenesis to accelerate healing in skin wound model
Authors: Mo Dongqin , Zhao Lixiang , Zhao Yanfei , Gao Linjing , Huang Yude , Fan Yiyang , Lu Haoyu , Wang Xian , Liu Zhiqing , Wang Yuetong , Li Yuetao , Wang Daiyou 
Published: February 2025

Abstract

Background
Promotion ofangiogenesis is a key aspect in accelerating wound healing. Therefore, exosomal therapy is a promising method for wound healing. Dicliptera Chinensis Polysaccharides (DCPs) have the potential to promote angiogenesis in tissues, and a hydrogel loaded with exosomes is an ideal delivery carrier. This study investigated the mechanism by which Pnipam-based hydrogel-loaded adipose-derived stem cell exosomes(ADSC-Exos) are stimulated by DCP in skin wound healing.
Methods
Exosomes secreted by adipose stem cells (ADSC-exosomes) was collected after stimulation DCP stimulation (DExos). In vitro experiments verified the ability of DExos to promote angiogenesis using the cell scratch technique, angiogenesis assay, RT-qPCR and Western Blotting using human umbilical vein endothelial cells (HUVEC) as a cell model. In vivo, a full skin defect was created on the backs of rats and Pnipam-based hydrogels loaded with DExo were injected into the defect. Wound healing was assessed morphologically and histologically.
Results
DExos promoted the cell migration rate and vasculogenic capacity of HUVECs and increased the cellular expression levels of CD 31, FGF 2, and VEGF-A. DExos-based poly(N-isopropylacrylamide) hydrogels (Pnipam@DExos) enabled the sustained release of DExos from the Pnipam-based hydrogel, which maintained high local concentrations at the wound site, promoting skin wound healing.
Conclusion
Pretreatment of ADSCs with DCPs improves the vasculogenic capacity of exosomes and pnipam@DExos promotes skin wound healing by slowly releasing DExos.
The potential of White Stork Ciconia ciconia nest lining to evaluate the functional diversity of coleopteran fauna – a case study of a novel non-invasive method of bioindicative evaluation across a land-use intensity gradient
Authors: Orłowski Grzegorz , Kitowski Ignacy , Czarnecka Joanna , Grzywaczewski Grzegorz , Ścibior Radosław 
Published: February 2025

Abstract

Collecting arthropod samples is usually very invasive because these organisms die during sampling, and it is hard to obtain a statistically robust sample. The availability of arthropods is critical for the survival of the youngest White Stork Ciconia ciconia nestlings conditioning the productivity of their populations; thus, the species is a strong predator of a variety of epigeic insects. At the time of the dietary shift and progressive drying of climatic conditions due to climate change or/and in dry habitats replacing wetlands, the role of such termophilic taxa as certain Coleoptera is often underestimated. Here, we evaluated the coleopteran component of the diet of the White Stork using the nest lining material, i.e. fragmented remains of regurgitated pellets, and related the community indices of Coleopteran fauna to the landscape structure within a radius of 2.5 km around nests. In eight nests in SE Poland, we found a massive accumulation of beetle remains representing 32 277 individual Coleopteran prey items, from which 17 252 were identified to the family level. Our analysis showed a significant relationship between the landscape structure and beetle communities, as well as the abundance of dominant prey taxa and share of three major functional guilds (herbivores, scavengers, and predators). The three most abundant prey taxa were large bodied epigeic taxa representing three families: carabidae, silphidae, and scarabidae, whose contribution increased with the share of tree cover and decreased with the share of arable land. The contribution of herbivorous and predatory beetles increased with the share of arable land. We have evidenced that the analysis of nest lining material provides a taxonomically informative data on beetle communities and can be a valuable tool in biondicative assessments of Coleopteran biodiversity. Given the widespread nesting of White Stork near landfills (increasing the productivity of their local populations), further studies assessing the role of the Coleopteran component, particularly the contribution of necrophagous or saprophagous beetles, in the diet of early nestlings of this bird species are essential.
Efficient and Scalable Data Pipelines: The Core of Data Processing in Gig Economy Platforms
Authors: Chen Junjie 
Published: February 2025

Abstract

The gig economy is characterized by rapid fluctuations in demand and a diverse array of data generated from various sources. Timely and efficient data processing is critical for platforms operating in this landscape, as they require real-time analytics to inform decision-making and enhance service offerings. In this paper, we introduce a comprehensive framework designed to develop efficient and scalable data pipelines tailored for gig economy platforms. Our framework focuses on systematically managing data processing tasks and offers a modular architecture that integrates multiple data sources seamlessly. It incorporates both stream and batch processing paradigms to optimize data flow and reduce latency. By utilizing microservices architecture, the framework enables independent component deployment, providing greater resilience and adaptability. Testing with extensive benchmarks on real-world datasets demonstrates improvements in processing speeds and resource efficiency in comparison to traditional methods, ultimately empowering gig economy platforms to handle large volumes of data effectively and respond adeptly to changing market dynamics.
Exploring Mosul Food Proverbs: A Cognitive Perspective
Authors: Muhammed Idrees Hasan  
Published: February 2025

Metaphor stands out as one of the most well-known theories that deal with non-literal language. This concept is viewed by Lakoff and Johnson (1980a) as understanding abstract concepts through more tangible objects. This view differs from other theories that consider metaphor as merely as a play of words. This research investigates the utilization of food metaphors in Mosuli Arabic proverbs. Its aim is to shed light on the bases and motives of these metaphors; furthermore, it seeks how abstract ideas are conceptualized and comprehended through the use of terms related to food in Mosuli Arabic proverbs. It hypothesizes that food-related terms are employed to comprehend and interpret a diverse range of abstract concepts. Furthermore, it suggests that the bases of metaphor are culture and experience.
Written and oral data are collected then analysed on two levels: the first level is concerned with getting the correct explanation and discourse scenarios where these proverbs might be used. The second level consists of two sub-levels. Two models are used on the first part to investigate implicit metaphors. The two models are taken from the works of Lakoff and Turner (1989) on "GENERIC IS SPECIFIC" and Lakoff and Johnson (2003) on "Metaphors We Live By." Thus, the two models are used to reveal the metaphorical meaning of food in Mosuli Arabic proverbs. The second part investigates explicit metaphors using the paradigm proposed by Lakoff and Johnson (2003). This research concludes that the conceptual metaphor theory is able to reveal a various number of abstract ideas that are comprehended in reference to more tangible objects. Additionally, the metaphorical conceptualization is motivated by experience and cultural values.
(دەقئاوێزانی کولتوری لە دیوانی(کارێزە مەرجان)ی موحسین ئاوارەدا)
Authors: Ismail Hamadameen Sleman  
Published: February 2025

پوختە
دەقئاوێزانی کولتوری لە دیوانی ( کارێزە مەرجان)ی موحسین ئاوارەدا، توێژینەوەیەکی زانستییە و بەرگی یەکەمی دیوانی (کارێزە مەرجان)ی (موحسین ئاوارە) وەک کەرەستەی ئەو توێژینەوەیە بەکارهاتووە. لە توێژینەوەکەدا پشت بە ڕێبازەکانی (وەسفی - شیکاری) بەستراوە ، ئەم توێژینەوەیە هەوڵێکە بۆ زیاتر شیکردنەوەی پەیوەندی نێوان کولتور و ئەدەب بە گشتی و شیعر بە تایبەتی و وێستگەی بە یەکگەیشتنیان. کولتور بەشێکی گرنگی نەتەوەیە و هۆکاری سەرەکی مانەوە و زیندووهێشتنەوەی نەتەوەکانە.
لەم توێژینەوەیەدا کۆمەڵێک پرسیاری سەرەکی هەبوون بە پێی توانا وەڵاممان داوەتەوە، بۆ نموونە: چەمک و زاراوەی دەقئاوێزان چییە؟ یاسا و جۆرەکانی کامانەن؟ هەروەها چەمک و زاراوەی کولتور چییە و بەشەکانی کامانەن؟ ئایا موحسین ئاوارە لەم دیوانە شیعریەدا تا چ ڕادەیەک توانیویەتی گشت بەشەکانی کولتور دەقئاوێزانی ناو دەقی شیعرەکانی بکات؟ بەدرێژایی توێژینەوەکە هەوڵمانداوە بەشێوەی تیۆری و پراکتیکی وەڵامی ئەم پرسیارانە بدەینەوە.
توێژینەوەکە جگە لە پێشەکی و ئەنجام ولیستی سەرچاوەکان و پوختە لە دوو بەشی سەرەکی پێکهاتووە، بەم شێوەیەی خوارەوە: بەشی یەکەم خۆی لە دوو تەوەرەی سەرەکی دەبینێتەوە : تەوەرەی یەکەم باسی چەمک و زاراوەکانی دەقئاوێزان، پێناسەی دەقئاوێزان، باسی جۆر و یاسا و میکانزمەکانی دەقئاوێزان کراوە. تەوەرەی دووەمیش باسی چەمک و زاراوەی کولتور و پێناسەی کولتور، بەشەکانی کولتور کراوە. بەشی دووەم بەشێوەکی پراکتیکی بەرگی یەکەمی دیوانی (کارێزە مەرجان)ی شاعیر(موحسین ئاوارە)مان وەرگرتووە، بە پێی توانا گشت بەشەکانی کولتورمان باسکردووە.
وشە سەرەکییەکان: (دەقئاوێزان، کولتور، موحسین ئاوارە ، دابونەریت، فۆلکلۆر)