bluuebunny/crossref_metadata_2025_split huggingface dataset:
Osteomielitis crónica no bacteriana
Authors: González Diego , Cameto Juan , Méndez Cecilia , Pacheco Cristina , Sandin Daniela , De Izaguirre María , Bódega Laura 
Published: August 2024

Introducción: la osteomielitis crónica no bacteriana (CNO) es una enfermedad autoinflamatoria ósea y se manifiesta con un amplio espectro clínico, presentándose con afectación monofocal o multifocal. Dado que no es siempre multifocal o recurrente, o ambas, fue propuesto que CNO se utilice como un término que comprenda a todas las presentaciones y la osteomielitis multifocal crónica recurrente (CRMO) se utilice para formas recurrentes y multifocales.
Objetivo: presentar un caso clínico inédito, de baja prevalencia a nivel mundial, en una adolescente portadora de una enfermedad autoinflamatoria ósea que planteó desafíos diagnósticos y terapéuticos.
Descripción: adolescente, mujer, 11 años, previamente sana que se presentó con dorso-lumbalgia invalidante de un mes de evolución, sin otra sintomatología asociada. Tras varias consultas en emergencia, ingresa a planta de internación pediátrica del Hospital Central de las Fuerzas Armadas (HCFFAA) en octubre de 2021. Resonancia nuclear magnética (RNM) de columna evidencia foco de edema óseo en cuerpo de T11, hemograma normal; VES 48 mm/h, ANA, anti-DNA, FR y HLA B27 negativos.
Resultados: luego de descartar procesos infecciosos, oncohematológicos y una vez obtenido el resultado de una biopsia por punción ósea que evidenciaba elementos inflamatorios, se llegó al diagnóstico de CNO en el mes de febrero de 2022, tiempo récord comparando este caso con la literatura internacional. El diagnóstico de esta entidad clínica promedio a nivel mundial es de 12 meses.
Hábitos alimentarios y caries de la primera infancia en una población uruguaya
Authors: Giacosa Marianella , Souza Evelyn , Tourn Melisa , Liberman Judith , García Graciela , Fabruccini Anunzziatta , Álvarez Licet 
Published: August 2024

Objetivo: conocer la relación entre el perfil de consumo de alimentos (frecuencia y tipo) con la prevalencia, extensión y distribución de las lesiones de caries en niños de 18-35 meses de la ciudad de Montevideo, Uruguay.
Material y método: se realizó un estudio transversal con una muestra no probabilística de 50 niños, de ambos sexos. Los padres respondieron a un cuestionario sobre datos sociodemográficos, hábitos alimenticios e higiene bucal. Dos examinadoras calibradas registraron las lesiones de caries de acuerdo al criterio ICDAS-epi, índice de placa visible e índice PUFA. Se realizaron análisis descriptivos para caries dental y dieta (tipo de alimento, incorporación y frecuencia).
Resultados: los niños examinados presentaban una edad promedio de 26,6±5,9 meses. La prevalencia de caries fue de 34%, con una extensión de 2,3 y 4,3 para ceo-d y ceo-s, respectivamente. Mayoritariamente se observaron lesiones severas, no tratadas, en el sector anterosuperior y posteroinferior. El índice PUFA fue de 8%. El 30% consumía leche materna, 54% leche con azúcar y el 100% consumía diariamente bebidas azucaradas no lácteas y alimentos azucarados antes de los 11 meses de vida. Los niños que consumían bebidas azucaradas (no lácteas) en biberón presentaron mayor extensión y severidad de las lesiones de caries (ceo-d modificado = 3,5 y ceo-s modificado = 7,8).
Conclusiones: el conocimiento de los patrones de alimentación en la primera infancia necesitan ser profundizados. La población estudiada mostró la temprana incorporación de azúcar a la dieta, alertando sobre la presencia de un factor de riesgo común a diversas enfermedades no transmisibles (caries, diabetes, obesidad, enfermedades cardiovasculares).
GOLPUT SEBAGAI BENTUK KURANGNYA PARTISIPASI MASYARAKAT DALAM BERPOLITIK STUDI DI DESA PRINGGABAYA
Authors: Septayana Ina , Mustari Mohamad 
Published: August 2024

Tujuan penelitian ini adalah untuk mengetahui pola interaksi sosial masyarakat di era digital di desa pringgabaya. Pendekatan yang digunakan adalah pendekatan kualitatif dengan jenis studi kasus. Sumber data adalah masyarakat di desa pringgabaya. Teknik pengumpulan data berupa teknik observasi. Hasil penelitian (1) bentuk interaksi sosial masyarakat diera digital di Desa Pringgabaya yaitu menggunakan media sosial (2) dampak positif dan dampak negatif berkomunikasi secara tidak langsung. Adapun dampak negatifnya yaitu; timbulnya rasa saling tidak menyukai atau persaingan antar masyarakat, menimbulkan banyak konflik. Dampak positifnya yaitu; menghemat waktu, jangkaun komunikasi lebih luas, dan mempercepat penyebaran informasi (3) dampak positif dan dampak negatif berkomunikasi secara langsung, adapun dampak negatifnya; kurang update dalam informasi atau kejadian terkini, tidak dapat melakukan komunikasi secara luas, tidak menghemat waktu dan tempat. Dampak positifnya; menumbuhkan rasa kebersamaan, dapat memberikan respon atau tanggapan secara langsung, lebih fokus mendengarkan informasi atau cerita dari masyarakat lainnya, tidak menimbulkan banyak drama atau kesalah fahaman, informasi atau cerita pribadi lebih aman, dan mempererat hubungan antara masyarakat yang satu dengan yang lainnya (4) upaya masyarakat untuk menjaga kekompakan dan keharmonisan antar sesama masyarakat yaitu dengan membuat visi misi desa , mengadakan kegiatan bersama, mengadak pertemuan, memperbanyak komunikasi, dan saling sapa menyapa saat bertemu.
UPAYA PENINGKATAN HASIL BELAJAR PESERTA DIDIK DENGAN ASSESSMENT QUIZZIZ PAPER MODE DI SMP NEGERI 38 PALEMBANG
Authors: Restaviana Imanda , Alfiandra  
Published: August 2024

Penelitian ini bertujuan untuk mendeskripsikan penerapan quizziz paper mode yang dapat meningkatkan hasil belajar peserta didik pada mata pelajaran PPKn kelas VII,4 di SMP Negeri 38 Palembang. Penelitian ini menggunakan metode Penelitian Tindakan Kelas, didalam metode PTK ada 4 tahap yang harus dilakukan peneliti yakni; 1) Perencanaan; 2) Tindakan; 3) Pengamatan; dan 4) Refleksi. Kegiatan dilakukan selama 3 siklus yaitu; 1) Pra siklus; 2) Siklus 1; dan 3) Siklus 2. Instrumen yang digunakan untuk mengetahui hasil belajar peserta didik yaitu menggunakan tes pilihan ganda. Soal yang dibuat berdasarkan pembelajaran yang telah dilakukan atau tindakan yang sudah dirancang pada tahap perencanaan. Pada pra siklus didapatkan hasil rata-rata nilai hanya 57,2, dan peserta didik yang mencapai KKM hanya 13 peserta didik serta persentasenya 36%. Selanjutnya pada siklus I dan II terus mengalami peningkatan mulai dari rata-rata nilai menjadi 66,9 dan 89,7 dan persentasenya mencapai 61% dan 83%. Peserta didik yang mencapai KKM sebanyak 30 orang. Berdasarkan hasil dari penelitian maka kesimpulannya yakni penggunaan quizziz mode paper dapat meningkatkan hasil belajar peserta didik pada mata pelajaran PPKn.
The Role of Inflammation and Psycho-Behavioral Factors as Mediators Between Acculturation and Time to Incident Dementia Among Older Mexican Americans
Authors: Nianogo Roch A. , Hays Ron D. , Gong Yufan , Yu Yu , Ritz Beate , Duru O. Kenrik 
Published: August 2024

Background: The mechanisms through which acculturation influences the onset of cognitive impairment and dementia are not well understood, especially among older Hispanics. Objective: To investigate whether inflammation and psycho-behavioral factors mediate the relationship between acculturation and incident dementia among older Mexican Americans. Methods: We analyzed the Sacramento Area Latino Study on Aging (1998–2007, SALSA), a longitudinal study ( N = 1,194) with 10 years of follow-up, and used g-computation for mediation analysis with pooled logistic regression to evaluate whether acculturation (assessed by the Revised Acculturation Rating Scale for Mexican Americans [ARSMA-II]) affected dementia or cognitive impairment but not dementia (CIND) through inflammation (i.e., interleukin 6 [IL-6], tumor necrosis factor- α (TNF- α), high-sensitivity C-reactive protein [hs-CRP]), smoking, alcohol consumption, and depressive symptoms. The potential mediators were assessed at baseline. Results: The 10-year average adjusted risk ratio (aRR) for the effect of high U.S. acculturation and dementia/CIND was 0.66, 95% CI (0.36, 1.30). The indirect effects were: IL-6 (aRR = 0.98, 95% CI (0.88, 1.05)); TNF- α (aRR:0.99, 95% CI (0.93, 1.05)); hs-CRP: (aRR = 1.21, 95% CI (0.84, 1.95)); current smoking: aRR = 0.97, 95% CI (0.84, 1.16); daily/weekly alcohol consumption (aRR = 1.00, 95% CI (0.96, 1.05)); and depressive symptom score (aRR = 1.03, 95% CI (0.95, 1.26)). Hs-CRP yielded a proportion mediated of -26%, suggesting that hs-CRP could suppress the potential effect of high U.S. acculturation. The other factors explored resulted in little to no mediation. Conclusions: The effect of acculturation on time to incident dementia/CIND varied over time. Our study suggests that inflammation could suppress the effect between high U.S. acculturation and dementia risk.
Convergent Multimodal Imaging Abnormalities in the Dorsal Precuneus in Subjective Cognitive Decline
Authors: Li Xuan-Yu , Yuan Li-Xia , Ding Chang-Chang , Guo Teng-Fei , Du Wen-Ying , Jiang Jie-Hui , Jessen Frank , Zang Yu-Feng , Han Ying 
Published: August 2024

Background: A range of imaging modalities have reported Alzheimer’s disease-related abnormalities in individuals experiencing subjective cognitive decline (SCD). However, there has been no consistent local abnormality identified across multiple neuroimaging modalities for SCD. Objective: We aimed to investigate the convergent local alterations in amyloid-β (Aβ) deposition, glucose metabolism, and resting-state functional MRI (RS-fMRI) metrics in SCD. Methods: Fifty SCD patients (66.4±5.7 years old, 19 men [38%]) and 15 normal controls (NC) (66.3±4.4 years old, 5 men [33.3%]) were scanned with both [18F]-florbetapir PET and [18F]-fluorodeoxyglucose PET, as well as simultaneous RS-fMRI from February 2018 to November 2018. Voxel-wise metrics were retrospectively analyzed, including Aβ deposition, glucose metabolism, amplitude of low frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality(DC). Results: The SCD group showed increased Aβ deposition and glucose metabolism ( p < 0.05, corrected), as well as decreased ALFF, ReHo, and DC ( p < 0.05, uncorrected) in the left dorsal precuneus (dPCu). Furthermore, the dPCu illustrated negative resting-state functional connectivity with the default mode network. Regarding global Aβ deposition positivity, the Aβ deposition in the left dPCu showed a gradient change, i.e., Aβ positive SCD > Aβ negative SCD > Aβ negative NC. Additionally, both Aβ positive SCD and Aβ negative SCD showed increased glucose metabolism and decreased RS-fMRI metrics in the dPCu. Conclusions: The dorsal precuneus, an area implicated in early AD, shows convergent neuroimaging alterations in SCD, and might be more related to other cognitive functions (e.g., unfocused attention) than episodic memory.
The Association of Brain Insulin Resistance with Anesthesia/Surgery-Induced Cognitive Deterioration Is Female-Specific in 5XFAD Transgenic Mice
Authors: Zhang Junyao , Zhang Yinglin , Zhang Yingying , Yao Junyan 
Published: August 2024

Background: Our previous studies indicated that anesthesia/surgery could aggravate cognitive impairment and tau pathology in female 5XFAD transgenic (Tg) mice. However, it is unknown whether there are sex differences in the susceptibility of developing postoperative cognitive dysfunction in 5XFAD Tg mice. Objective: In this study, we aim to determine whether anesthesia/surgery can have different effects on female and male 5XFAD Tg mice, and to explore the underpinning mechanisms. Methods: The mice received abdominal surgery under isoflurane anesthesia. Morris water maze was used to assess the cognitive function. Hippocampal levels of p-tau (AT8), p-IRS1 (Ser612), IRS1, p-GSK3β (Tyr216), and p-GSK3β (Ser9) at postoperative day 1 were evaluated by western blot assays. Results: Anesthesia/surgery exaggerated cognitive impairment and tau pathology in female, but not male 5XFAD Tg mice. The anesthesia/surgery led to elevated hippocampus protein levels of p-IRS1 (Ser612)/IRS1 ratio and p-GSK3β (Tyr216) and reduced hippocampus protein levels of p-GSK3β (Ser9) in female, but not male 5XFAD Tg mice. Conclusions: This study demonstrated that female 5XFAD Tg mice were more susceptible to anesthesia/surgery-induced cognitive deterioration and tau pathology aggravation, potentially due to female-specific brain insulin resistance.
The Add Health Parent Study: A Biosocial Resource for the Study of Multigenerational Racial/Ethnic Disparities in Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias
Authors: Perreira Krista M. , Hotz V. Joseph , Duke Naomi N. , Aiello Allison E. , Belsky Daniel W. , Brown Tyson , Jensen Todd , Harris Kathleen Mullan 
Published: August 2024

Background: Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRD) have increased in prevalence. Objective: This article describes the Add Health Parent Study (AHPS) Phase 2, a study of social, behavioral, and biological factors influencing healthy aging and risk for AD/ADRD, in a national sample of adults aged 58–90. Methods: Sample members are parents of the National Longitudinal Study of Adolescent to Adult Health (Add Health) cohort, initially interviewed in Add Health in midlife (1994-95). AHPS Phase 1 (2015–17) collected longitudinal data on a random subsample of parents and their spouse/partners, who were mostly Non-Hispanic (NH) White. AHPS Phase 2 will collect the same longitudinal socio-behavioral, and health survey data on all remaining NH Black and Hispanic parents (Black and Hispanic Supplement, BHS). Additionally, Phase 2 will collect cognitive and DNA data from AHPS Phase 1 and BHS sample parents and their current spouse/partners. Results: Funded by the National Institute on Aging, recruitment will occur between June 2025 and May 2026, producing an expected total AHPS sample of 5506 parents and their spouse/partners. Conclusions: The AHPS will be the first longitudinal cohort study powered to address multigenerational racial/ethnic disparities in AD/ADRD risk and protective factors across race/ethnic groups and socioeconomic strata.
Characteristics and Transcriptomic Analysis of Cholinergic Neurons Derived from Induced Pluripotent Stem Cells with APP Mutation in Alzheimer’s Disease
Authors: Sun Wenxian , Chen Yufei , Yang Yuting , Wang Pin , Gong Jin , Han Xiaodong , Xu Chang , Luan Heya , Li Shaoqi , Li Ruina , Wen Boye , Lv Sirong , Wei Cuibai 
Published: August 2024

Background: The cholinergic hypothesis is one of the main theories that describe the pathogenesis of Alzheimer’s disease (AD). Cholinergic neurons degenerate early and are severely damaged in AD. Despite extensive research, the causes of cholinergic neuron damage and the underlying molecular changes remain unclear. Objective: This study aimed to explore the characteristics and transcriptomic changes in cholinergic neurons derived from human induced pluripotent stem cells (iPSCs) with APP mutation. Methods: Peripheral blood mononuclear cells from patients with AD and healthy individuals were reprogrammed into iPSCs. The iPSCs were differentiated into cholinergic neurons. Cholinergic neurons were stained, neurotoxically tested, and electrophysiologically and transcriptomically analyzed. Results: The iPSCs-derived cholinergic neurons from a patient with AD carrying a mutation in APP displayed enhanced susceptibility to Aβ1-42-induced neurotoxicity, characterized by severe neurotoxic effects, such as cell body coagulation and neurite fragmentation. Cholinergic neurons exhibited electrophysiological impairments and neuronal death after 21 days of culture in the AD group. Transcriptome analysis disclosed 883 differentially expressed genes (DEGs, 420 upregulated and 463 downregulated) participating in several signaling pathways implicated in AD pathogenesis. To assess the reliability of RNA sequencing, the expression of 16 target DEGs was validated using qPCR. Finally, the expression of the 8 core genes in different cell types of brain was analyzed by the AlzData database. Conclusions: In this study, iPSCs-derived cholinergic neurons from AD patients with APP mutations exhibit characteristics reminiscent of neurodegenerative disease. Transcriptome analysis revealed the corresponding DEGs and pathways, providing potential biomarkers and therapeutic targets for advancing AD research.
Automatic anal sphincter integrity detection from ultrasound images via convolutional neural networks
Authors: Chen Bin , Yi Yinqiao , Zhang Chengxiu , Yan Yulin , Wang Xia , Shui Wen , Zhou Minzhi , Yang Guang , Ying Tao 
Published: August 2024

BACKGROUND: The anal sphincter complex comprises the anal sphincter and the U-shaped deep and superficial puborectalis muscle. As an important supporting structure of the posterior pelvic floor, together with its surrounding tissues and muscles, the anal sphincter complex maintains the normal physiological functions of defecation and continence. OBJECTIVE: The plane required for diagnosing anal sphincter injury and the diagnosis of anal sphincter integrity through pelvic floor ultrasound are highly dependent on sonographers’ experience. We developed a deep learning (DL) tool for the automatic diagnosis of anal sphincter integrity via pelvic floor ultrasound. METHODS: A 2D detection network was trained to detect the bounding box of the anal sphincter. The pelvic floor ultrasound image and its corresponding oval mask were input into a 2D classification network to determine the integrity of the anal sphincter. The average precision (AP) and intersection over union (IoU) were used to evaluate the performance of anal sphincter detection. Receiver operating characteristic (ROC) analysis was used to evaluate the performance of the classification model. RESULTS: The Pearson correlation coefficients ([Formula: see text] values) of the topmost and bottommost layers detected by the CNN and sonographers were 0.932 and 0.978, respectively. The best DL model yielded the highest area under the curve (AUC) of 0.808 (95% CI: 0.698–0.921) in the test cohort. The results from the CNN agreed well with the diagnostic results of experienced sonographers. CONCLUSIONS: We proposed, for the first time, a CNN to obtain the plane required for diagnosing anal sphincter injury on the basis of pelvic floor ultrasound and for preliminarily diagnosing anal sphincter injury.
ANALYSIS OF THE INFLUENCE OF EXTERNAL FACTORS ON THE DEFORMATION OF HIGH-RISE BUILDINGS IN THE PROCESS OF THEIR CONSTRUCTION AND OPERATION
Authors: Demyanenko Roman , Annenkov Andriy , Bondar Svitlana , Kuzmych Oleksandr , Tsykolenko Olena 
Published: August 2024

During the construction and operation of high-rise buildings, their vertical axis changes its position in space. The greater the height of the structure, the greater the amplitude of oscillations. This causes problems of geodetic construction support and the need to monitor deformations during the operation of high-rise structures. In real conditions, part of the structures will be in the shade and their temperature will be lower than the structures that will be under the influence of solar radiation, the temperature of which will be much higher. Thus, the building will deform as a result of uneven thermal expansion, that is, it will bend. From DBN B.1.3-2:2010 "Geodesic works in construction". Also, during the geodetic provision of the construction and operation of high-rise buildings, changes in the temperature regime of building structures should be taken into account in connection with significant absolute values of changes in the geometric dimensions of the building as a result of thermal expansion, which significantly exceed the accuracy regulated by the regulatory document. The article examines and analyzes the influence of external forces on changes in the geometry of high-rise structures and focuses attention on solving the scientific problem of geodetic support for the construction and operation of modern high-rise structures under dynamic loads.
DESIGN OF ANTI-EROSION HYDRAULIC AND FORESTRY MEASURES TO COMBAT RAVINES
Authors: Kyryliuk Volodymyr , Rozhi Tomas , Dets Tetiana 
Published: August 2024

The article discusses the design of anti-erosion hydraulic and forestry measures to combat ravines in the territory of Kopenkuvate village, Golovanivsky district, Kirovohrad region.
It has been established that climatic conditions (especially the distribution of precipitation, both in terms of the growing season and the intensity of precipitation) in some periods contribute to the acceleration of water erosion, especially gully erosion.
According to hydrological calculations, the volume of runoff from the 10% snowmelt was 6792 m3, and the total solid runoff was 476 m3. An earthen rampart 186 m long and 2.0 m high was designed to capture the runoff.
Reducing erosion intensity to acceptable levels is the main criterion for selecting erosion control measures. In addition to the agrotechnical erosion control measures used, the farm selected and designed their combination with hydrotechnical and forest reclamation measures that meet this condition.
Simultaneously with the installation of the water retention berm, we create a forest strip along the ravine, which is placed on both sides of the ravine along its sides at a distance of 5 meters from them. The strip is 0.526 km long, 12.5 m wide, and has 5 rows. Amount of planting material: common oak - 1.052 thousand pieces; pear - 0.375 thousand pieces; white acacia - 0.375 thousand pieces; common dog rose - 0.750 thousand pieces; sea buckthorn - 1.052 thousand pieces.
To strengthen the bottom of the ravine, we plan to install 15 wicker dams. The bottom of the ravine will be used for continuous forestation. To reforest the ravine bottom with an area of 0.52 hectares, we need 1,733 thousand poplar plants and 0.867 thousand rose hips.
The complex of anti-erosion measures will reduce the intensity of erosion processes and the formation of ravines on agricultural lands.
PENDIDIKAN KARAKTER MELALUI PEMBELAJARAN BAHASA INDONESIA DENGAN MATERI MEMBACA NOVEL SASTRA
Authors: Nugrahani Farida 
Published: August 2024

Penelitian pengembangan ini bertujuan untuk (1) mengembangkan bahan ajar bahasa Indonesia dengan materi membaca novel sastra untuk pendidikan karakter yang valid, praktis, dan efektif melalui uji coba di lapangan. (2) mendeskripsikan nilai karakter yang terdapat dalam bahan ajar tersebut dan keberhasilan implementasinya dalam pembelajaran di sekolah, Penelitian ini dilakukan melalui empat tahap, mengikuti model Plomp (1997), yaitu:(1) pengkajian awal, (2) perancangan, (3) realisasi (konstruksi), dan (4) validasi/revisi. Hasil penelitian menunjukkan bahwa (1) bahan ajar yang dikembangkan bersifat valid, praktis, dan efektif untuk diterapkan di lapangan; (2) Terdapat nilai karakter religius, kejujuran, dan kedisiplinan dalam bahan ajar yang dikembangkan, yang implementasinya dapat dipantau melalui 6 indikator dari 11 rumusan indikator dalam Character Education Patnership (2003). Pada akhirnya, hasil penelitian ini diharapkan dapat memberikan sumbangan terhadap program pendidikan karakter di sekolah, khususnya dalam memberikan alternaif bahan ajar bahasa Indonesia yang praktis, efektif, dan diminati siswa.