bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug-induced dyskinesia in Parkinson's disease. Should success in clinical management be a function of improvement of motor repertoire rather than amplitude of dyskinesia?
Authors: Daneault Jean-François , Carignan Benoit , Sadikot Abbas F , Panisset Michel , Duval Christian 
Published: March 2013

Abstract

Background
Dyskinesia, a major complication in the treatment of Parkinson's disease (PD), can require prolonged monitoring and complex medical management.

Discussion
The current paper proposes a new way to view the management of dyskinesia in an integrated fashion. We suggest that dyskinesia be considered as a factor in a signal-to-noise ratio (SNR) equation where the signal is the voluntary movement and the noise is PD symptomatology, including dyskinesia. The goal of clinicians should be to ensure a high SNR in order to maintain or enhance the motor repertoire of patients. To understand why such an approach would be beneficial, we first review mechanisms of dyskinesia, as well as their impact on the quality of life of patients and on the health-care system. Theoretical and practical bases for the SNR approach are then discussed.

Summary
Clinicians should not only consider the level of motor symptomatology when assessing the efficacy of their treatment strategy, but also breadth of the motor repertoire available to patients.
Influence of high-density lipoprotein cholesterol on coronary collateral formation in a population with significant coronary artery disease
Authors: Hsu Po-Chao , Su Ho-Ming , Juo Suh-Hang , Yen Hsueh-Wei , Voon Wen-Chol , Lai Wen-Ter , Sheu Sheng-Hsiung , Lin Tsung-Hsien 
Published: March 2013

Abstract

Background
Coronary collateral circulation plays an important role in protecting myocardium from ischemia and reducing cardiovascular events. Low High-density lipoprotein cholesterol (HDL-C) level is a strong risk factor for coronary artery disease (CAD) and is associated with poor cardiovascular outcome. It was recently reported to be associated with poor coronary collateral development in Turkish population. Hence, we investigated the influence of HDL-C on coronary collateral formation in Chinese population.

Methods
We evaluated 970 consecutive patients undergoing coronary angiography, and 501 patients with significant coronary artery disease (SCAD) were finally analyzed. The collateral scoring system developed by Rentrop was used to classify patient groups as those with poor or good collaterals.

Results
The patients with poor collaterals had fewer diseased vessels (1.97 ± 0.84 vs 2.47 ± 0.68, p < 0.001) and lower diffuse score (2.65 ± 1.63 vs 3.76 ± 1.78, p < 0.001). There was no significant difference in HDL-C and other variables between good and poor collaterals. Multivariate analysis showed only number of diseased vessels (odd ratio 0.411, p < 0.001) was a significant predictor of poor collateral development.

Conclusions
The extent of CAD severity but not HDL-C level was the most powerful predictor of coronary collateral formation in our Chinese population with SCAD.
Monitoring cartilage loss in the hands and wrists in rheumatoid arthritis with magnetic resonance imaging in a multi-center clinical trial: IMPRESS (NCT00425932)
Authors: Peterfy Charles G , Olech Ewa , DiCarlo Julie C , Merrill Joan T , Countryman Peter J , Gaylis Norman B 
Published: March 2013

Abstract
Introduction
Magnetic resonance imaging (MRI) is increasingly being used in clinical trials of rheumatoid arthritis (RA) because of its superiority over x-ray radiography (XR) in detecting and monitoring change in bone erosion, osteitis and synovitis. However, in contrast to XR, the MRI scoring method that was used in most clinical trials did not include cartilage loss. This limitation has been an obstacle to accepting MRI as a potential alternative to XR in clinical trials. Cross-sectional studies have shown MRI to be sensitive for cartilage loss in the hands and wrist; although, longitudinal sensitivity to change has not yet been confirmed. In this study we examined the ability of MRI to monitor change in cartilage loss in patients with RA in a multi-site clinical trial setting.

Methods
Thirty-one active RA patients from a clinical trial (IMPRESS) who were randomized equally into treatment with either rituximab + methotrexate or placebo + methotrexate had MRI of the dominant hand/wrist at baseline, 12 weeks and 24 weeks at 3 clinical sites in the US. Twenty-seven of these patients also had XR of both hands/wrists and both feet at baseline and 24 weeks. One radiologist scored all XR images using the van der Heijde-modified Sharp method blinded to visit order. The same radiologist scored MR images for cartilage loss using a previously validated 9-point scale, and bone erosion using the Outcome Measures in Rheumatology Clinical Trials (OMERACT) RA MRI Score (RAMRIS) blinded to visit order and XR scores. Data from the two treatment arms were pooled for this analysis.

Results
Mean MRI cartilage score increased at 12 and 24 weeks, and reached statistical significance at 24 weeks. XR total Sharp score, XR erosion score and XR joint-space narrowing (JSN) score all increased at 24 weeks, but only XR total Sharp score increased significantly.

Conclusions
To our knowledge, this is the first publication of a study demonstrating MRI's ability to monitor cartilage loss in a multi-site clinical trial. Combined with MRI's established performance in monitoring bone erosions in RA, these findings suggest that MRI may offer a superior alternative to XR in multi-site clinical trials of RA.
Prospective cohort study of the circadian rhythm pattern in allogeneic sibling donors undergoing standard granulocyte colony-stimulating factor mobilization
Authors: Shi Patricia A , Isola Luis M , Gabrilove Janice L , Moshier Erin L , Godbold James H , Miller Lorraine K , Frenette Paul S 
Published: March 2013

Abstract
Introduction
Prior in vivo murine studies suggest circadian oscillations for hematopoietic stem cell release, which are maintained following administration of granulocyte colony-stimulating factor (G-CSF) or plerixafor. Furthermore, retrospective data analysis of healthy donors who underwent G-CSF-induced mobilization demonstrated significantly increased CD34+ cell yields when collected in the afternoon compared with the morning.

Methods
A prospective study was conducted to directly examine the number of peripheral blood CD34+ and CD34+CD38– progenitor/stem cells at baseline and then every 6 hours for 24 hours on days 4 to 5 of G-CSF (10 μg/kg/day in the morning) mobilization in 11 allogeneic donors. Data were analyzed using mixed-model analysis of repeated measures.

Results
Whereas we observed a significant increase in CD34+ cell counts toward the evening, counts were then sustained on the morning of day 5. The correlation between CD34+CD38– cell counts and the less defined CD34+ populations was weak.

Conclusions
Our results suggest that the pharmacodynamic activity and timing of G-CSF may alter endogenous progenitor rhythms. Donor age, medical history, and medications may also impact circadian rhythm. Further studies should examine the circadian rhythm at the peak of G-CSF mobilization and should consider potential confounders such as the time of G-CSF administration and the age of the subjects.
First application of Green’s theorem-derived source and receiver deghosting on deep-water Gulf of Mexico synthetic (SEAM) and field data
Authors: Mayhan James D. , Weglein Arthur B. 
Published: March 2013

Deghosting benefits traditional seismic processing and is a prerequisite to all inverse-scattering-series based processing. The freedom of choosing a convenient reference medium (and associated Green’s function) means Green’s theorem offers a flexible framework for deriving useful algorithms including deghosting. Among advantages over traditional deghosting methods are: (1) no need for Fourier transforms over receivers and sources, and (2) can accommodate a horizontal or non-horizontal measurement surface, the latter of particular interest for ocean bottom and onshore applications. The theory of Green’s theorem-derived deghosting is presented, and its first application on deep-water Gulf of Mexico synthetic (SEAM) and field data is reported. The source and receiver deghosting algorithms work with positive and encouraging results.
Formation of Rectangular Plate-like α-MnOOH and Sheet-like γ-MnOOH by Slow Diffusion of Ammonia Vapor
Authors: Kajiyama Satoshi , Kumagai Hiromu , Nishimura Tatsuya , Kato Takashi 
Published: March 2013

Abstract
The formation of rectangular plate-like α-MnOOH and sheet-like γ-MnOOH crystals has been achieved under ambient conditions. A gradual crystallization of manganese compounds with the diffusion of ammonia vapor inhibits random oxidization of divalent manganese ions and the formation of aggregates of Mn3O4 crystals. The simple method using ammonia vapor is applicable to the development of manganese-based compounds with ordered structures.
Mutation detection in cholestatic patients using microarray resequencing of ATP8B1 and ABCB11
Authors: McKay Kirsten E , Bruce Christopher K , Hartley Jane L , Knisely A S , Baumann Ulrich , Bockisch Sonja-Stephanie , Sturm Ekkehard , Hendriksz Christian J , Kelly Deidre A , Macdonald Fiona , Gissen Paul 
Published: March 2013

Background: Neonatal cholestasis is a common presentation of childhood liver diseases and can be a feature of various conditions including disorders of bile acid biogenesis and transport, various inborn errors of metabolism and perinatal infections. Some inherited metabolic diseases can be easily screened using biochemical assays, however many can only be accurately diagnosed by DNA sequencing. Fluorescent capillary Sanger sequencing (FS) is the gold standard method used by clinical laboratories for genetic diagnosis of many inherited conditions; however, it does have limitations. Recently microarray resequencing (MR) has been introduced into research and clinical practice as an alternative method for genetic diagnosis of heterogeneous conditions. In this report we compared the accuracy of mutation detection for MR with FS in a group of patients with ‘low-normal’ gamma glutamyl transpeptidase (gGT) cholestasis without known molecular diagnoses.Methods: 29 patient DNA samples were tested for mutations in the ATP8B1 and ABCB11 genes using both FS and MR. Other known causes of “low gGT cholestasis” such as ARC syndrome and bile acid biosynthesis disorders were excluded.Results: Mutations were identified in 13/29 samples. In 3/29 samples FS and MR gave discordant results: MR had a false positive rate of 3.4% and a false negative rate of 7%.Conclusions: The major advantage of MR over FS is that multiple genes can be screened in one experiment, allowing rapid and cost-effective diagnoses. However, we have demonstrated that MR technology is limited in sensitivity. We therefore recommend that MR be used as an initial evaluation, with FS deployed when genetic and clinical or histopathological findings are discordant.
Non-isothermal crystallization kinetics of poly (lactic acid)/graphene nanocomposites
Authors: Chen Yanhua , Yao Xiayin , Gu Qun , Pan Zhijuan 
Published: March 2013

Abstract
Poly(lactic acid) (PLA)/graphene nanocomposites were prepared by solution blending and the dispersibility of graphene in the PLA matrix was examined by transmission electron microscopy (TEM). The non-isothermal crystallization behaviors of pure PLA and PLA/graphene nanocomposites from the melt were investigated by differential scanning calorimetry (DSC). The results showed that the graphene could play a role as a heterogeneous nucleating agent during the non-isothermal crystallizing process of PLA, and accelerate the crystallization rate. The non-isothermal crystallizing data were analyzed with the Avrami, Ozawa and Mo et al. models and the crystallization parameters of the samples were obtained. It is demonstrated that the combination of the Avrami and Ozawa models developed by Mo et al. was successful in describing the non-isothermal crystallization process for pure PLA and its nanocomposite. According to the Kissinger equation, the activation energies were found to be -154.3 and -179.5 kJ/mol for pure PLA and PLA/0.1 wt% graphene nanocomposite, respectively. Furthermore, the spherulite growth behavior was investigated by polarized optical microscopy (POM) and the results also supported the DSC data.
Predictors for long-term outcome and quality of life of patients after cardiac surgery with prolonged intensive care unit stay
Authors: Grothusen Christina , Attmann Tim , Friedrich Christine , Freitag-Wolf Sandra , Haake Nils , Cremer Jochen , Schöttler Jan 
Published: March 2013

Abstract

Objectives
This study investigated factors determining the long-term outcome and quality of life of patients with a prolonged intensive care unit (ICU) stay after cardiac surgery.

Design
A retrospective analysis was performed in 230 patients that had undergone cardiac surgery and suffered from a post-operative ICU stay of 7 or more days at our institution. Among 11 pre-, 13 intra-, and 14 post-operative variables, factors influencing 5-year outcome were identified by logistic regression analysis. Quality of life was determined using the Short Form-36 questionnaire.

Results
In-hospital mortality was 12%. One hundred and eleven of 187 patients (59%) were alive after 5 years. Non-survivors were older (70 vs. 65 years, p=0.005) and had a higher additive EuroSCORE (7 vs. 5, p=0.034). Logistic regression identified pre-operative atrial fibrillation (AF), (28 vs. 10%, p=0.003) as the strongest predictor for a 5-year outcome, followed by myocardial infarction (62 vs. 41%, p=0.005), and prolonged mechanical ventilation (8 vs. 5 days, p=0.036). Survivors did not show an impaired physical component summary SF-36 score (39 vs. 46, p=0.737) or mental component summary score (55 vs. 55, p=0.947) compared to an age-matched German Normative Sample.

Conclusions
Pre-operative AF proved to be the most important factor determining the 5-year outcome of patients with a prolonged ICU stay after cardiac surgery. Neither physical nor mental health appeared to be impaired in these patients.
Contrast-enhanced ultrasound (CEUS) and CEUS-guided biopsy in the diagnosis of lung abscess in a patient with achalasia: Case report
Authors: Di Vece Francesca , Tombesi Paola , Ermili Francesca , Sartori Sergio 
Published: March 2013

Abstract
Primary achalasia is a rare disorder of unknown aetiology characterized by dysfunction of esophageal motility secondary to degeneration of esophageal neurons. Some diseases, in particular neoplastic diseases, can cause symptoms similar to achalasia, and this condition is called pseudoachalasia. Pseudoachalasia can be indistinguishable from primary achalasia, and many investigations are often necessary to detect or exclude an underlying neoplasia. We report a case in which thoracic contrast-enhanced ultrasound (CEUS) and percutaneous CEUS-guided lung biopsy played a central role in differentiating aspiration pneumonia secondary to achalasia and complicated by lung abscess from pseudoachalasia secondary to lung carcinoma, after computed tomography (CT) yielded inconclusive findings. US contrast agent SonoVue® has an exclusively intravascular distribution, and its ability to discriminate between contrast vascular signal and tissue signal is greater than that of CT, making CEUS superior to CT in distinguishing perfused, viable tissues from avascular necrotic tissues. Although its use in pleuropulmonary pathology is still off-label, CEUS can play a useful role in characterizing peripheral pulmonary masses in selected cases.
Hyperhomocysteinemia in a young woman presenting with acute myocardial infarction: Case report
Authors: Gokay Seher , Çiçek Davran , Müderrisoğlu Haldun 
Published: March 2013

Abstract
Homocysteine (Hcy), a sulfur-containing amino acid that is formed by demethylation of dietary methionine to cystein. Elevated homocysteine level is known to be associated with coronary artery disease. We present a case of acute myocardial infarction in a 25-year-old woman, associated with hyperhomocysteinaemia. Her other risk factors for coronary artery disease were smoking, a moderately high LDL level, and a family history of sudden cardiac death. This case illustrates the need to include plasma homocysteine measurement in the setting of acute coronary syndromes in women with premature atherosclerosis, even in the presence of traditional risk factors for coronary artery disease.
Evaluation Of The Capacity Of Granulation In Surgical Wounds with Condensed Tannins in Matrices Tio2.
Authors: Rodrìguez José Albino M. , López José Rutilio M. , Gutiérrez Genaro C. , Coronel Marco-Antonio G , Mora Enrique S. , Rodríguez Lilián-Aurora M , Rodríguez Fernando M. 
Published: March 2013

ABSTRACT.The nanoencapsulation in biocompatible inorganic materials with human cell activity is a leading technology to control the process of releasing the drug in the right place. At present, the sol-gel process has emerged as a promising platform for the immobilization, stabilization and encapsulation of biological molecules such as enzymes, antibodies, microorganisms, and a variety of drugs. The matrices obtained are chemically inert, hydrophilic and easy synthesis. They have high mechanical strength, thermal stability in wide temperature ranges and absorb organic solvents so insignificant compared with other organic polymers. They are resistant to microbial attack and exhibit high biocompatibility with the body, as provided for implantation in situ in the treatment of various diseases. An additional advantage is that it provides viability encapsulated molecules, since these matrices act as reservoirs of water thus helping to maintain the biological activity of enzymes, antibodies, cells, and drugs for the moisture level required for the molecule. We used the action of the active ingredients of tepezcohuite (condensed tannins) to assess the capacity aseptic surgical wound healing than 1 cm in diameter in New Zealand white rabbits. Experimentally and statistically demonstrating the effectiveness of healing nanoreservoirs Tan/TiO2-150 the weight of tannins by 60% compared to condensed tannins as such, TiO2and isotonic saline.
Cyclotriveratrylene Dendrimers
Authors: Sanchez-Montes Karla E. , Klimova Tatiana , Martínez-Klimov Mark E. , Martínez-García Marcos. 
Published: March 2013

ABSTRACTDendrons with dodecyl ended groups joined benzyloxy moieties were attached to a cyclotriveratrylene core. The dendrimers were used in Diederich cyclopropanation reaction with the fullerene C60. The structure of the synthesized dendrimers was confirmed by 1H- and 13C-NMR, MALDI-TOF mass spectrometry and elemental analysis.
The Effect of Anodization Time on the Properties of TiO2 Nanotube Humidity Sensors
Authors: Raman Reshmi , Jaramillo Oscar A. , Rincón Marina E. 
Published: March 2013

ABSTRACTIn this paper, the effect of anodization time on the properties of TiO2 nanotube humidity sensors is reported. TiO2 nanotube arrays were grown by anodization of Ti foil using diethylene glycol and ammonium fluoride. Highly ordered TiO2 nanotube arrays were obtained, with the length of tube increasing from 4 to 20 μm as the time of anodization increases, at the expense of nanotube integrity. Humidity sensors based on TiO2 nanotube arrays were fabricated in impedance mode with ITO as top contact. The results revealed that sensor performance does not correlate with anodization time, regardless of enhanced area, showing an optimum morphology at 4h and 10h. The increase resistivity of the sensors upon water exposure, a donor molecule, is explained by the lack of TiO2 stoichiometry and the fluctuations in the concentration of oxygen vacancies.
Adhesive Energy of Zinc Oxide and Graphite, Molecular Dynamics and Atomic Force Microscopy Study
Authors: Galan Ulises , Sodano Henry A. 
Published: March 2013

AbstractMolecular Dynamics (MD) simulations are performed to calculate the interfacial energy between zinc oxide (ZnO) and graphitic carbon for the study of solid–solid adhesion. The MD model consists of a ZnO slab and a single layer of graphitic carbon. The calculation was validated experimentally by atomic force microscopy (AFM) liftoff. A polishing process was applied to create a tip with a flat surface that was subsequently coated with a ZnO film allowing force displacement measurement on Highly Oriented Pyrolitic Graphite to validate the simulations. The MD simulation and AFM lift-off show good agreement with adhesive energies of 0.303 J/m2 and 0.261 ± 0.054 J/m2, respectively.
Conductance Properties of Multilayered Silver-Mean and Period-Doubling Graphene Structures
Authors: Rodríguez-Arellano G. , Juárez-López D. P. , Madrigal-Melchor J. , Martínez-Orozco J. C. , Rodríguez-Vargas I. 
Published: March 2013

ABSTRACTIn this work we alternate breaking-symmetry-substrates (BSS) and non-breaking-symmetry-substrates (NBSS) such as SiC and SiO2,following the Silver-Mean (MSMGS) and Period-Doubling (MPDGS) sequences. We implement the Transfer Matrix technique to calculate the transmittance and the linear-regime conductance as a function of the most relevant parameters of the multilayered graphene structures: energy and angle of incidence, widths of BSS and NBSS regions and the generation of the quasi-regular sequence. We analyze the main difference of the transmission and conductance properties between MSMGS and MPDGS.
Hydrostatic pressure effects onto the electronic structure and differential capacitance profile for a metal/δ-doped-GaAs.
Authors: Puga A. , Martínez-Orozco J. C. 
Published: March 2013

ABSTRACTA metal-semiconductor contact with a n-type δ-doped quantum well of impurities (metal/δ-doped GaAs) was studied numerically to extract electronic properties such as energy levels and the corresponding wave functions of each level as well as the differential capacitance for the structure. In this work we reported these properties as a function of the hydrostatic pressure (p). We used the effective mass approximation for the calculation of the electronic structure and consider the hydrostatic pressure effects on the basic semiconductor parameters as is the effective mass for the conduction electrons and the static dielectric constant, finally we also take into account an experimental expression that dependency of the Schottky barrier height as a function of this external factor, at least for values between 0 and 6 kar. We showed that the linear behavior for C−2, obtained by pervious works, is switched over a parabolic-like curve due to the δ-doped two-dimensional impurities density.
Effect of Ball Milling on Magnetic Properties of Nb Substituted R2Fe16Nb1 (R: Gd and Er) Alloys
Authors: Rai B. K. , Mishra S. R. , Khanra S. , Ghosh K. 
Published: March 2013

AbstractIn this work, we report the effect of high energy ball milling (HEBM) on Nb doped R2Fe16Nb1 (R= Gd, Er) compounds. The focus of the work is to bring enhancement in magnetic properties of R2Fe17 (2:17) compounds with the ball milling. Specifically, we find that the ball milling increases saturation magnetization, coercivity, and Curie temperature. The increase in the magnetization and Curie temperature upon ball milling is related to the lattice expansion and microstrains while the increase in coercivity is related to the grain refinement.