bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A Pd‐Catalyzed One‐Pot Dehydrogenative Aromatization and ortho‐Functionalization Sequence of N‐Acetyl Enamides.
Authors: Kim Jinhee , Moon Youngtaek , Lee Suhyun , Hong Sungwoo 
Published: July 2014

AbstractThe alkenylation of (XIII) to (XIV) is accompanied by the formation of 8‐13% of di‐olefinated products.
ChemInform Abstract: The N‐Alkylation of Sulfonamides with Alcohols in Water Catalyzed by the Water‐Soluble Iridium Complex {Cp*Ir[6,6′‐(OH)2bpy](H2O)}[OTf]2.
Authors: Qu Panpan , Sun Chunlou , Ma Juan , Li Feng 
Published: July 2014

AbstractThe presence of the two hydroxy groups in the bipyridine ligand are crucial for the catalytic activity.
ChemInform Abstract: Changing the Reaction Pathway by NHC/Broensted Base Cooperative Catalysis: Highly Stereoselective Synthesis of Multifunctional Benzo[a]fluoren‐11‐ones from the Dimerization of 2‐(Aroylvinyl)arylaldehydes.
Authors: Tong Yuan‐feng , Mao Jian‐hui , Wu Song , Zhao Yuan , Cheng Ying 
Published: July 2014

AbstractThe unprecedented title synthesis requires both the triazole catalyst and 4‐methoxyphenolate as a co‐catalyst and proceeds via a benzoin‐Michael‐Michael cascade reaction sequence.
ChemInform Abstract: Practical Iron‐Catalyzed Hydrogen Peroxide Epoxidation of Aromatic Olefins Using a Combination of Two Kinds of Simple Picolinate Ligands under Halide‐Free Reaction Conditions.
Authors: Chishiro Takefumi , Kon Yoshihiro , Nakashima Takuya , Goto Midori , Sato Kazuhiko 
Published: July 2014

AbstractFe‐catalyzed oxidation of styrenes to epoxides by H2O2 is achieved in good yields and realized on a 100‐g scale.
ChemInform Abstract: Regio‐ and Enantioselective Synthesis of N‐Allylindoles by Iridium‐Catalyzed Allylic Amination/Transition‐Metal‐Catalyzed Cyclization Reactions.
Authors: Ye Ke‐Yin , Dai Li‐Xin , You Shu‐Li 
Published: July 2014

AbstractThe title reaction is realized through an iridium‐catalyzed asymmetric allylic amination reaction with various alkynylanilines and subsequent cyclization.
ChemInform Abstract: Catalytic Enantioselective Intramolecular Cyclization of N‐Aryl Diazoamides Using a Titanium—BINOLate Complex.
Authors: Hashimoto Takuya , Yamamoto Kumiko , Maruoka Keiji 
Published: July 2014

AbstractAddition of an external proton source such as 4‐bromo‐2,6‐di‐tert‐butylphenol allows a lowered catalyst loading, while slightly decreasing the yield and enantiomeric excess as well as prolonging the reaction time.
ChemInform Abstract: 2‐Trifluoromethylated Indoles via Radical Trifluoromethylation of Isonitriles.
Authors: Zhang Bo , Studer Armido 
Published: July 2014

AbstractTitle compounds are readily synthesized by the trifluoromethylation of isonitriles employing the Togni reagent (II) as a CF3 radical precursor.
ChemInform Abstract: A Solvent‐Free Protocol for the Synthesis of 3‐Formyl‐2H‐chromenes via Domino Oxa Michael/Aldol Reaction.
Authors: Lanari Daniela , Rosati Ornelio , Curini Massimo 
Published: July 2014

AbstractSubstrates with electron‐withdrawing groups give the undesired hemiacetal (V) as major product.
ChemInform Abstract: Copper‐Catalyzed Aerobic Oxidative Annulation and Carbon—Carbon Bond Cleavage of Arylacetamides: Domino Synthesis of Fused Quinazolinones.
Authors: Sun Jie , Tan Qitao , Yang Wusong , Liu Bingxin , Xu Bin 
Published: July 2014

AbstractCu‐catalyzed tandem reactions of phenylacetic acid amides having a 2‐pyridyl or related heteroaryl substituent proceed through aerobic benzylic oxidation, intermolecular cyclization, and decarbonylation to yield a variety of fused quinazolines.
ChemInform Abstract: The Synthesis of Benzo[a]phenazine‐5,6‐dione 7‐Oxides.
Authors: Gornostaev L. M. , Lyashchenko T. A. , Arnold E. V. 
Published: July 2014

AbstractThe title compounds (II), a new type of tetracyclic azine heterocycles incorporating quinoid structures, are conveniently obtained by treatment of naphthoquinones (I) with nitrosylsulfuric acid.
ChemInform Abstract: Short Synthesis of Berkeleyamide D and Determination of the Absolute Configuration by the Vibrational Circular Dichroism Exciton Chirality Method.
Authors: Komori Kenta , Taniguchi Tohru , Mizutani Shoma , Monde Kenji , Kuramochi Kouji , Tsubaki Kazunori 
Published: July 2014

AbstractSynthetic (.+‐.)‐(I) is separated by optical resolution using chiral HPLC to (‐)‐I* and its enantiomer.
ChemInform Abstract: The Directed ortho Metalation‐Cross‐Coupling Fusion: Development and Application in Synthesis: Platinum Group Metals Catalytic Synthetic Strategy for Pharmaceutical, Agrochemical and Other Industrial Products
Authors: Board Johnathan , Cosman Jennifer L. , Rantanen Toni , Singh Suneel P. , Snieckus Victor 
Published: July 2014

AbstractReview: 88 refs.
Enhanced Oxygen Separation through Robust Freeze‐Cast Bilayered Dual‐Phase Membranes
Authors: Gaudillere Cyril , Garcia‐Fayos Julio , Balaguer María , Serra José M. 
Published: July 2014

AbstractDual‐phase oxygen‐permeable asymmetric membranes with enhanced oxygen permeation were prepared by combining freeze‐casting, screen‐printing, and constraint‐sintering techniques. The membranes were evaluated under oxyfuel operating conditions. The prepared membranes are composed of an original ice‐templated La0.6Sr0.4Co0.2Fe0.8O3−δ support with hierarchically oriented porosity and a top fully densified bilayered coating comprising a 10 μm‐thick La0.6Sr0.4Co0.2Fe0.8O3−δ layer and a top protective 8 μm‐thick layer made of an optimized NiFe2O4/Ce0.8Tb0.2O2−δ composite synthesized by the one‐pot Pechini method. Preliminary analysis confirmed the thermochemical compatibility of the three involved phases at high temperature without any additional phase detected. This membrane exhibited a promising oxygen permeation value of 4.8 mL min−1 cm−2 at 1000 °C upon using Ar and air as the sweep and feed gases, respectively. Mimicking oxyfuel operating conditions by switching argon to pure CO2 as a sweep gas at 1000 °C and air as feed enabled an oxygen flux value of 5.6 mL min−1 cm−2 to be reached. Finally, under the same conditions and increasing the oxygen partial pressure to 0.1 MPa in the feed, the oxygen permeation reached 12 mL min−1 cm−2. The influence of CO2 content in the sweep gas was studied and its reversible and positive effect over oxygen permeation at temperatures equal to or above 950 °C was revealed. Finally, the membrane stability over a period of 150 h under CO2‐rich sweep gas showed a low degradation rate of 2.4×10−2 mL min−1 cm−2 per day.
Global DNA methylation as a possible biomarker for diabetic retinopathy
Authors: Maghbooli Zhila , Hossein‐nezhad Arash , Larijani Bagher , Amini Manochehr , Keshtkar Abbasali 
Published: July 2014

AbstractBackgroundWe evaluated whether global levels of DNA methylation status were associated with retinopathy as well as providing a predictive role of DNA methylation in developing retinopathy in a case–control study of 168 patients with type 2 diabetes.MethodsThe 5‐methylcytosine content was assessed by reversed‐phase high‐pressure liquid chromatography of peripheral blood leukocytes to determine an individual's global DNA methylation status in the two groups, either with or without retinopathy.ResultsThe global DNA methylation levels were significantly higher in diabetic retinopathy patients compared with those in non‐retinopathy patients (4.90 ± 0.12 vs. 4.22 ± 0.13, respectively; p = 0.001). There was a significant increasing trend in global DNA methylation levels in terms of progressing retinopathy (without retinopathy, 4.22 ± 0.13; non‐proliferative diabetic retinopathy, 4.62 ± 0.17; proliferative diabetic retinopathy, 5.07 ± 0.21) (p = 0.006). Additionally, global DNA methylation independent of retinopathy risk factors, which include dyslipidaemia, hypertension, hyperglycaemia and duration of diabetes, was a predictive factor for retinopathy (OR = 1.53, p = 0.015).ConclusionsGlobal DNA methylation is modulated during or possibly before the primary stage of diabetes. This observation verifies the metabolic memory effect of hyperglycaemia in early stage of an aetiological process that leads to type 2 diabetes and its associated complications. Copyright © 2014 John Wiley & Sons, Ltd.
A standardized method for quantifying unidirectional genetic introgression
Authors: Karlsson Sten , Diserud Ola H. , Moen Thomas , Hindar Kjetil 
Published: July 2014

AbstractGenetic introgression of domesticated to wild conspecifics is of great concern to the genetic integrity and viability of the wild populations. Therefore, we need tools that can be used for monitoring unidirectional gene flow from domesticated to wild populations. A challenge to quantitation of unidirectional gene flow is that both the donor and the recipient population may be genetically substructured and that the subpopulations are subjected to genetic drift and may exchange migrants between one another. We develop a standardized method for quantifying and monitoring domesticated to wild gene flow and demonstrate its usefulness to farm and wild Atlantic salmon as a model species. The challenge of having several wild and farm populations was circumvented by in silico generating one analytical center point for farm and wild salmon, respectively. Distributions for the probability that an individual is wild were generated from individual‐based analyses of observed wild and farm genotypes using STRUCTURE. We show that estimates of proportions of the genome being of domesticated origin in a particular wild population can be obtained without having a historical reference sample for the same population. The main advantages of the method presented are the standardized way in which genetic processes within and between populations are taken into account, and the individual‐based analyses giving estimates for each individual independent of other individuals. The method makes use of established software, and as long as genetic markers showing generic genetic differences between domesticated and wild populations are available, it can be applied to all species with unidirectional gene flow. Results from our method are easy to interpret and understand, and will serve as a powerful tool for management, especially because there is no need for a specific historical wild reference sample.
Line Loss Minimization Control in a Loop Distribution System Using Circulating Current Compensation and Reactive Current Suppression by a Unified Power Flow Controller
Authors: Yamada Kazuhei , Takeshita Takaharu , Kunii Yasuyuki , Ueda Fukashi 
Published: July 2014

SUMMARYThis paper describes line loss minimization control using the shunt and series converters of a UPFC (unified power flow controller) in a loop distribution system. The line losses in a loop distribution system are caused by the circulating current flowing in the loop and the mesh currents flowing to the loads. The authors have previously proposed a compensation method for circulating current using a series converter. In this paper, the authors propose a suppression method for reactive currents using a shunt converter. In the prototype model of a loop distribution system, a theoretical loss reduction ratio of 92% without line loss caused by active currents is obtained. Similar line loss reduction characteristics are obtained in experiments using the prototype distribution system.
Double‐Switch Series‐Resonant Cell‐Voltage Equalizer Using a Voltage Multiplier for Series‐Connected Energy Storage Cells
Authors: Uno Masatoshi , Kukita Akio 
Published: July 2014

SUMMARYSeries connections of energy storage cells, such as lithium‐ion cells and electric double‐layer capacitors (EDLCs), require cell‐voltage equalizers to ensure years of operation. Conventional equalizers require multiple switches, magnetic components, and/or secondary windings of a multiwinding transformer in proportion to the number of series connections, which usually makes them complex, expensive, bulky, and less extendable with increasing series connections. A double‐switch series‐resonant equalizer using a voltage multiplier is proposed in this paper. The double‐switch operation without a multiwinding transformer achieves simplified circuitry and good modularity at reduced size and cost, compared to conventional equalizers. Operational analyses were separately performed for the following two functional parts of the proposed equalizer: a series‐resonant inverter and a voltage multiplier. The mathematical analyses derived a dc‐equivalent circuit of the proposed equalizer, with which simulation analyses of even an hour's duration can be completed in an instant. Simulation analyses were separately performed for both the original and equivalent circuits. The simulation results of the derived circuit correlated well with those of the original circuit, thus verifying the derived dc‐equivalent circuit. A 5‐W prototype of the proposed equalizer was built for eight cells connected in series and an experimental equalization was performed for series‐connected EDLCs from an initially voltage‐imbalanced condition. The voltage imbalance was gradually eliminated over time, and the standard deviation in the cell voltages decreased to approximately 5 mV at the end of the experiment, thus demonstrating the equalization performance of the proposed equalizer.
Optimal Power Distribution on Decentralized Energy Networks with Battery Degradation Control
Authors: Kato Shinya , Taniguchi Ittetsu , Sakakibara Kazutoshi , Fukui Masahiro 
Published: July 2014

SUMMARYThis paper proposes an optimal power distribution method on a decentralized energy network with battery degradation control. Because battery degradation is unavoidable in battery utilization, we solve the optimal power distribution problem by an MIP formulation to keep the battery degradation to a minimum.
A Multiagent‐Based Microgrid Operation Method
Authors: Nagata Takeshi , Kato Kosuke , Utatani Masahiro , Ueda Yuji , Okamoto Kazuya , Nagata Chihiro 
Published: July 2014

SUMMARYIn this paper, we propose an autonomous microgrid operation using a multiagent approach. The proposed multiagent system consists of seven types of agent: a single microgrid controller agent (MGC), several load agents (LAGs), several gas‐turbine (gas‐engine) agents (GAGs), several photovoltaic generation agents (PVAGs), several wind‐turbine generation agents (WTAGs), several battery agents (BAGs), and a single grid agent (GridAG). In a microgrid, LAGs act as consumers or buyers, GAGs, PVAGs, and WTAGs act as producers or sellers, and BAGs act as prosumers or sellers/buyers. In order to verify the performance of the proposed system, it is applied to a simple model system with different electrical power prices. From the simulation results, it can be seen that the proposed multiagent system can perform microgrid operations efficiently.
Chronic baroreflex activation effects on sympathetic nerve traffic, baroreflex function, and cardiac haemodynamics in heart failure: a proof‐of‐concept study
Authors: Gronda Edoardo , Seravalle Gino , Brambilla Gianmaria , Costantino Giuseppe , Casini Andrea , Alsheraei Ali , Lovett Eric G. , Mancia Giuseppe , Grassi Guido 
Published: July 2014

AimsHeart failure (HF) pathophysiology is believed to be mediated by autonomic dysfunction, including chronic sympathoexcitation and diminished baroreflex sensitivity, which correlate with mortality risk. Baroreflex activation therapy (BAT) is a device‐based treatment providing chronic baroreflex activation through electrical stimulation of the carotid sinus. BAT chronically reduces sympathetic activity in resistant hypertension. The purpose of this investigation is to determine BAT effects in clinical HF.Methods and resultsIn a single‐centre, open‐label evaluation, patients with NYHA class III HF, EF <40%, optimized medical therapy, and ineligible for cardiac resynchronization received BAT for 6 months. Efficacy was assessed with serial measurement of muscle sympathetic nerve activity (MSNA) and clinical measures of quality of life and functional capacity. Eleven patients participated in the trial. MSNA was reduced over 6 months from 45.1 ± 7.7 to 31.3 ± 8.3 bursts/min and from 67.6 ± 12.7 to 45.1 ± 11.6 bursts/100 heartbeats, decreases of 31% and 33%, respectively (P < 0.01). Concomitant improvements occurred in baroreflex sensitivity, EF, NYHA class, quality of life and 6 min hall walk (6MHW) distance (P ≤ 0.05 each). On an observational basis, hospitalization and emergency department visits for worsening HF were markedly reduced. One complication, perioperative anaemia requiring transfusion, occurred during the study.ConclusionBAT was safe and provided chronic improvement in MSNA and clinical variables. Based on present understanding of HF pathophysiology, these results suggest that BAT may improve outcome in HF by modulating autonomic balance. Prospective, randomized trials to test the hypothesis are warranted.
Synthesis, Structure, and Photophysical Properties of Blue‐Emitting Zinc(II) Complexes with 3‐Aryl‐Substituted 1‐Pyridylimidazo[1,5‐a]pyridine Ligands
Authors: Ardizzoia G. Attilio , Brenna Stefano , Durini Sara , Therrien Bruno , Veronelli Mattia 
Published: July 2014

AbstractSix zinc(II) complexes of the general formula [Zn(LR)X2] (1: R = Me, X = Cl; 2: R = Me, X = Br; 3: R = Me, X = I; 4: R = OH, X = Cl; 5: R = OH, X = Br; 6: R = OH, X = I), in which LR is 1‐(pyridin‐2‐yl)‐3‐o‐tolylimidazo[1,5‐a]pyridine (LMe) or 2‐[1‐(pyridin‐2‐yl)imidazo[1,5‐a]pyridin‐3‐yl]phenol (LOH), have been prepared and characterized. The X‐ray structural analysis performed on complexes 1, 3, and 4 showed that both LMe and LOH act as N,N‐bidentate ligands and coordinate to the ZnII metal center through the pyridine ring (Npy) and the pyridine‐like nitrogen atom of the imidazo[1,5‐a]pyridine group (Nim). The photophysical properties of these compounds have been investigated, both in solution and in the solid state. The complexes showed intense blue luminescence when excited with UV light (λexc = 366–410 nm) with λmax of emission between 440–460 nm in the solid state. Complexes 1–3 showed moderate‐to‐good absolute photoluminescence quantum yields (PLQYs) in the solid state with a maximum PLQY of 0.40 for 1. These values were slightly lower than the PLQY of free LMe (0.60). On the other hand, the PLQY of LOH increased after coordination to ZnCl2, and a PLQY of 0.29 was recorded for 4. A possible interpretation of this behavior is reported.
Synthesis of Atomically Precise Silver Clusters by Using the Miscibility Principle
Authors: Ghosh Atanu , Pradeep Thalappil 
Published: July 2014

AbstractA new strategy to synthesize a diverse array of organic‐soluble, atomically precise silver clusters has been developed. The technique is based on the miscibility principle of solvents and uses no phase‐transfer agents; various clusters of masses 8.0, 13.4, 22.8, 29.2, and 34.4 kDa were synthesized by changing the reactant composition. We have also synthesized the well‐known Au25(SR)18 cluster by the same method. Among the silver clusters formed, we have studied the new 13.4 kDa species, which has unique steplike features in its UV/Vis spectrum, in detail by mass spectrometry and other analytical techniques. The compound has been assigned as Ag68(SR)34, which is reported for the first time. By time‐dependent studies, we have shown that the synthetic route follows the bottom‐up approach. The material forms microcrystals. We hope that the proposed synthetic strategy will extend the area of atomically precise clusters.
Total Synthesis of Dictyodendrins B and E, and Formal Synthesis of Dictyodendrin C
Authors: Tao Pengyu , Liang Jingjing , Jia Yanxing 
Published: July 2014

AbstractA full account of the concise total syntheses of dictyodendrins B and E, and the formal synthesis of dictyodendrin C are described. A palladium‐catalysed Larock indole synthesis was used to form the highly substituted indole core, and a palladium‐mediated one‐pot consecutive Buchwald–Hartwig amination/C–H activation reaction was used to construct the key pyrrolo[2,3‐c]carbazole core. Unsuccessful synthetic strategies are also discussed.
A Short‐Step Synthesis of 1,6‐Methano[10]annulene‐3,4‐dicarboximides and Their Benzene‐, Naphthalene‐, and Thiophene‐Annulated Compounds
Authors: Oda Mitsunori , Nakamura Tomomi , Neha Miyako , Miyawaki Daisuke , Ohta Akira , Kuroda Shigeyasu , Miyatake Ryuta 
Published: July 2014

AbstractTriphenylphosphorane reagents 8 react with 1,3,5‐cycloheptatriene‐1,6‐dicarbaldehyde (2) under acidic as well as basic conditions to produce 1,6‐methano[10]annulene‐3,4‐dicarboximides 1 in moderate ‐to‐ good yields. The reagents 8 react with 3,4‐arene‐annulated 1,3,5‐cycloheptatriene‐1,6‐dicarbaldehydes 9, 10, and 11 to afford only the Wittig condensation products under acidic conditions but produce the arene‐annulated annulenedicarboximides under basic conditions. The structures of some of the dicarboximides and the intermediate Wittig condensation products were determined by X‐ray structural analysis. The emission properties of the dicarboximides were also studied.
Persistence of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the androgen 17β-trenbolone
Authors: Baumann Lisa , Knörr Susanne , Keiter Susanne , Nagel Tina , Rehberger Kristina , Volz Sina , Oberrauch Sophia , Schiller Viktoria , Fenske Martina , Holbech Henrik , Segner Helmut , Braunbeck Thomas 
Published: July 2014

Abstract

The aim of the present study was to investigate the effects of the androgenic endocrine disruptor 17β-trenbolone on the sexual development of zebrafish (Danio rerio) with special emphasis on the question of whether adverse outcomes of developmental exposure are reversible or persistent. An exposure scenario including a recovery phase was chosen to assess the potential reversibility of androgenic effects. Zebrafish were exposed to environmentally relevant concentrations of 17β-trenbolone (1 ng/L–30 ng/L) from fertilization until completion of gonad sexual differentiation (60 d posthatch). Thereafter, exposure was either followed by 40 d of recovery in clean water or continued until 100 d posthatch, the age when zebrafish start being able to reproduce. Fish exposed for 100 d to 10 ng/L or 30 ng/L 17β-trenbolone were masculinized at different biological effect levels, as evidenced from a concentration-dependent shift of the sex ratio toward males as well as a significantly increased maturity of testes. Gonad morphological masculinization occurred in parallel with decreased vitellogenin concentrations in both sexes. Changes of brain aromatase (cyp19b) mRNA expression showed no consistent trend with respect to either exposure duration or concentration. Gonad morphological masculinization as well as the decrease of vitellogenin persisted after depuration over 40 d in clean water. This lack of recovery suggests that androgenic effects on sexual development of zebrafish are irreversible. Environ Toxicol Chem 2014;33:2488–2496. © 2014 SETAC
Theoretical Study on Novel Mixed Valence, P‐H Functional P‐Ligands, and Their Tautomerization
Authors: Espinosa Arturo , Abdrakhmanova Liliya , Streubel Rainer 
Published: July 2014

ABSTRACTThe synthesis of a novel mixed valence P‐ligand system (II/I) with a PP bond bearing phosphonite and PH phosphanyl subunits was achieved via the reaction of a Li/Cl phosphinidenoid complex with a phosphite‐substituted ketone. Density functional theory (DFT) calculations provide insight into bonding features of the novel R(H)PP(OR′)2ligand system and its tautomer RP = PH(OR′)2. Wiberg bond index, Mayer bond order, and electron density at bond critical points are reported for both the free and ligated forms, pointing to a high degree of PP double bond character of the free ligand with a significant bond order decrease inend‐on pentacarbonyltungsten complexation.