bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Adamantinoid Basal Cell Epithelioma
Authors: Mohri Shinobu , Andoh Shin'ichiro , Matsushitay Kazuhiko , Konishi Yoshiro 
Published: April 2015

AbstractA 56‐year‐old woman visited the clinic of dermatology, Yokohama Sakae Kyosai Hospital in May of 1992 with a 5‐year history of a blue‐gray lesion on her left cheek which had enlarged asymptomatically. The tumor was excised with Z plasty closure.Histopathologically, a loosely encapsulated tumor was situated in the upper to deep dermis. At the periphery of the tumor, there were typical solid basal cell epithelioma (BCE) nests, but within the majority of lobules, intercellular spaces were widened and cells were connected by stellate appendages. Mucoid material filled the spaces and the cells at the periphery palisaded. Histochemical study revealed that the mucoid substance contained hyaluronic acid.An immunohistochemical study was performed using peroxidase antiperoxidase (PAP) method. The antibodies used were anti‐epithelial membrane antigen (EMA), anti‐carcinoembryonic antigen (CEA), anti‐S‐100 protein, anti‐neurofilament, anti‐vimentin, anti‐desmin, anti‐BRST‐1, and anti‐BRST‐2. The tumor cells and stroma expressed none of these antigens. The tumor was diagnosed as an adamantinoid BCE.
Cryosurgery and Topical Fluorouracil: A Treatment Method for Widespread Basal Cell Epithelioma in Basal Cell Nevus Syndrome
Authors: Tsuji Takuo , Otake Naoki , Nishimura Masahiro 
Published: April 2015

AbstractA 58‐year‐old man with basal cell nevus syndrome had variously sized basal cell epitheliomas (BCEs), mostly of the superficial type, on his chest, back, and lumbar areas.BCEs on the lumbar area were treated with 5‐fluorouracil (5‐FU) cream which was applied daily under occlusive dressings (ODT). Complete erosion occurred in the center, but not at the periphery of the lesions. In the latter regions, BCE remained. Then cryosurgery (cryo) followed by topical 5‐FU (cryo + 5‐FU) was tried to treat the peripheral, non‐eroded lesions; this caused complete erosions. Biopsy specimens obtained 6 months after epithelization did not show any evidence of recurrence.We also tried either cryo alone or cryo + 5‐FU on the chest lesions, and either 5‐FU alone or cryo + 5‐FU on the abdominal lesions. Cryo alone or 5‐FU alone could not clear BCE, but cryo + 5‐FU could.These results suggest that the cryo + 5‐FU was the most effective of these therapies.
Active Specific Immunotherapy of Malignant Melanoma with Anti‐idiotypic Monoclonal Antibodies
Authors: Ferrone Soldano , Kageshita Toshiro , Hirai Shunji 
Published: April 2015

AbstractIn this study, we have utilized the human high molecular weight‐melanoma associated antigen (HMW‐MAA) as a target for active specific immunotherapy with mouse anti‐idiotypic (anti‐id) monoclonal antibodies (mAb) in patients with malignant melanoma. After having summarized the characteristics of HMW‐MAA which account for its selection as a target for immunotherapy, we describe the development and characterization of mouse anti‐id mAb MK2‐23 which bears the internal image of HMW‐MAA. Furthermore, we describe the results of the first clinical trial performed with mouse anti‐id mAb MK2‐23 in patients with malignant melanoma.
Acquired Dermal Melanocytosis of the Hand: A New Clinical Type of Dermal Melanocytosis
Authors: Fukuda Michio , Kitajima Jun‐ichi , Fushida Hiroyo , Hamada Toshio 
Published: April 2015

AbstractWe report a 22‐year‐old man with acquired dermal melanocytosis on the hand which developed without any history of previous inflammation. He had no history of contact with or oral administration of any drugs or metals which might have caused pigmentation. Histopathologically, spindle‐shaped dermal melanocytes were observed running parallel to the collagen bundles and scattered in all portions of the dermis. The dopa reaction of these cells was positive. Ultrastructurally, dermal melanocytes containing numerous melanosomes (stages II to IV) which were surrounded by the extracellular sheath were observed. Differential diagnosis of other dermal melanocytosis was discussed.
Progressive Systemic Sclerosis Preceded by Malignant Lymphoma
Authors: Yamamoto Toshiyuki , Furuse Yoshiro , Nishioka Kiyoshi 
Published: April 2015

AbstractWe report a patient who suffered from progressive systemic sclerosis (PSS) two years after she showed evidence of malignant lymphoma of the jejunum. Surgical resection of the tumor mass and VEMP regimen were successful; the patient was in remission but died of acute respiratory failure five years later. Although several reports have reported malignant lymphoma associated with PSS, lymphoma antecedent to PSS is rarely seen. Immune abnormalities including a high titer of antinuclear factor and positive anti‐RNP antibodies were suspected to be associated with the development of PSS in our case.
Fibroma of Tendon Sheath with Ulceration
Authors: Chi Hyung‐In , Oda Junji 
Published: April 2015

AbstractWe describe a 44‐year‐old man with fibroma of tendon sheath. The tumor originated in the foot and developed an ulcer during its course. It was totally excised, and the defect was reconstructed by full‐thickness skin graft. The patient has been free of any recurrence during the follow‐up period of one year. Fibroma of tendon sheath rarely occurs in the foot, and, to our best knowledge, this condition with ulceration is the first case reported.
Progressive Alterations of Cytokeratin Expressions in the Process of Chronic Arsenism
Authors: Yu Hsin‐Su , Chiou Kuen‐Shing , Chen Gwo‐Shing , Yang Rei‐Cheng , Chang Shui‐Feng 
Published: April 2015

AbstractRecent studies of an endemic occurrence of chronic arsenism in a limited area on the southwest coast of Taiwan are focusing on its cytokeratin analysis in hopes of tracing the disease's biochemical expression. Specimens were obtained from uninvolved skin and arsenical cancers including Bowen's disease, basal cell carcinoma, and squamous cell carcinoma. In this study, we used two‐dimensional polyacrylamide gel electrophoresis to analyse cytokeratin expression. Progressive alterations in cytokeratin expression were found in various skin lesions. These include an expression of K16 in the uninvolved skin; K16 and K6 in Bowen's disease; and K16, K6 and K17 in squamous cell carcinoma and basal cell carcinoma. In addition, we found that the K1 isoelectric variants shifted to more acidic forms with the complete absence of K1 in basal cell carcinoma. K16 expression in uninvolved skin indicates that it is nevertheless in a hyperproliferative status. K17 was expressed in squamous cell carcinoma and basal cell carcinoma, but not in Bowen's disease. The progressive impairment of phosphorylation of K1 and K2 in the process of chronic arsenism provides us with a suitable model for studying the biological significance of phosphorylation in intermediate filaments during chemical carcinogenesis.
Cutaneous Metastases from Prostatic Cancer
Authors: Azaña J. Manuel , de Misa Ricardo F. , Gomez M. Isabel , del Hoyo Juan F. , Ledo Antonio 
Published: April 2015

AbstractThe skin is involved in metastases from 2–9% of malignant tumors. These usually tend to spread to the skin relatively late in the course of the disease. Skin metastases of prostatic origin are quite uncommon and preferentially localized to the lower abdomen and genital area. We present a case of cutaneous metastasis from prostatic adenocarcinoma that preceded diagnosis of the primary tumor and was located on the neck.
Evaluation of Phenolic Glycolipid‐I (PGL‐I) Antibody as a Multidrug Therapy (MDT) Monitor
Authors: Prakash Kunti , Sehgal Virendra N. , Aggarwal Ravindra 
Published: April 2015

AbstractSince phenolic glycolipid‐I (PGL‐I) is an unequivocal marker for Mycobacterium leprae, this antigen has been a good candidate for the serodiagnosis and monitoring of the effectiveness of leprosy chemotherapy. The present study, a continuation of an earlier report, was undertaken to estimate PGL‐I antibody titers in 40 leprosy patients 3 and 6 months after starting MDT. All the leprosy groups showed significant declines in anti PGL‐I reactivity after 6 months. There was a good correlation between bacteriological indices (BI) and anti PGL‐I antibody levels. Thus, PGL‐I based serology may be useful in monitoring the response to multidrug therapy.
Analysis of Lymphocyte Subpopulations in Peripheral Blood in Adult and Juvenile Cases of Dermatomyositis
Authors: Ishida Takeshi , Matsumoto Yoshinari , Ohashi Masaru , Sasaki Ryuichiro 
Published: April 2015

AbstractDermatomyositis, recognized as an autoimmune disorder, occurs not only in adults but also in children. In this study, we evaluated lymphocyte subpopulations in the peripheral blood of 24 adult dermatomyositis and 14 juvenile dermatomyositis patients and in 17 healthy adults and 9 healthy children by flow cytometry using monoclonal antibodies. When compared with healthy adults and adult patients with inactive dermatomyositis, the adult patients with active disease had significantly lower percentages of CD3+ and CD8+ cells and a significantly higher percentage of CD20+ cells. In contrast, juvenile dermatomyositis patients had lymphocyte subpopulations not significantly different from those of healthy children; the activity/inactivity of disease did not make any difference. These results support our hypothesis that adult and juvenile dermatomyositis may be diseases of entirely different scope.
Secretion of IL‐2, IL‐4, and IFN‐γ for Dust Mite Antigens in a Patient with Atopic Dermatitis
Authors: Kubota Yumiko , Koga Tetsuya , Imayama Shuhei , Hori Yoshiaki 
Published: April 2015

AbstractIn a 21‐year‐old female with severe atopic dermatitis, the secretion of interleukin‐2 (IL‐2), interleukin‐4 (IL‐4), and interferon‐γ (IFN‐γ) by her peripheral blood mononuclear cells (PBMC) was measured after incubation with/without antigens extracted from Dermatophagoides pteronyssinus (Dp), to which the patient had developed a positive patch‐test reaction. Incubation with Dp antigen produced marked secretion of IL‐2 and IFN‐γ, but not IL‐4. This may suggest that Dp‐specific T lymphocytes present in the circulating blood cells are capable of producing IL‐2 and IFN‐γ, which may be relevant to the delayed‐type allergic reaction occurring in the skin lesion.
Linear Lichen Planus Mimicking Creeping Eruption
Authors: Taniguchi Yoshiki , Minamikawa Mitsuyoshi , Shimizu Masayuki , Ando Katsuhiko , Yamazaki Satoshi 
Published: April 2015

AbstractA 42‐year‐old woman was referred to our hospital with a linear eruption on her right flank of two months duration. Because she had eaten loach‐fish a month before she noticed the eruption, a creeping eruption due to Gnathostoma spp. was initially suspected, but the histological findings of the biopsy specimens showed typical features of lichen planus. Linear lichen planus is discussed based on the cases accumulated in the literature regarding the distribution of Blaschko lines.
The Lymphocyte Transformation Test with Sulphadiminidum and with Prealbumin‐Sulphadiminidum Complex in Patients with Drug Allergy
Authors: Husz Sándor , Kenderessy Anna Szabó , Kiss Mária , Penke Botond , Dobozy Attila 
Published: April 2015

AbstractEarlier results (the absence or a decreased level of prealbumin [PA] in the serum, a higher proportion of PA‐bearing lymphocytes as antigen‐binding cells, and the presence of PA in the eluate of lymphocytes in patients with drug allergy) permitted the conclusion that, besides its other relevant functions, PA may also behave as a hapten carrier protein.The lymphocyte transformation test (LTT) involving measurement of 3H‐thymidine uptake was therefore carried out with sulphadiminidum (SA) alone, with the PA‐SA complex, and with the albumin‐SA complex in patients with proven (3 cases) or suspected (63 cases) sensitivity to SA.In all 3 cases with proven drug allergy to SA and in 5 of the 63 suspect cases, the LTT was positive in response to both the drug alone and to the PA‐SA complex (The albumin‐SA complex gave positivity in only one case). In 5 of the 63 suspect cases, the LTT was positive only in response to the PA‐SA complex. It is suggested that the sensitivity of the LTT could be increased if the test could be run with a complex of a protein (hapten carrier?) and a drug.
A Case of Goltz Syndrome Presenting as Congenital Incomplete Alopecia
Authors: Terashi Hiroto , Kurata Sotaro , Hashimoto Hiroyuki , Ishii Yoshiteru , Takasaki Shuji , Sonoda Tadashige , Takayasu Susumu , Honda Tomohito 
Published: April 2015

AbstractA 5‐year‐old Japanese girl had had localized, incomplete hair loss on the scalp, minimal distichia, and a small papillomatous eruption on the right upper eyelid since birth. The diagnosis of Goltz syndrome was made by histological findings such as upward extension of the subcutaneous tissue to the papillary dermis and marked diminution in the thickness of the dermis, although typical linear atrophy‐like eruptions and other mesoectodermal dysplasia were absent.
Histopathological and Electron Microscopical Features of Skin Lesions in a Patient with Bartonellosis (Verruga Peruana)
Authors: Bhutto Abdul Manan , Nonaka Shigeo , Hashiguchi Yoshihisa , L Eduardo A. Gomez 
Published: April 2015

AbstractChronic verruga nodules taken from a patient with Bartonellosis (verruga peruana) were studied. Histologically, specimens of all the verruga nodules had features consistent with granulomatous lesions with extensive infiltration of various types of cells along with the proliferation of capillaries. The sections were predominantly infiltrated with neutrophils and endothelial cells; histiocytes, plasma cells, lymphocytes and mast cells were also visible to some extent. The blood vessels were dilated, and many rounded and swollen endothelial cells were located peripherally; a huge number of neutrophils invaded the vessels. Electron microscopically, large number of organisms were seen in different stages of the life cycle in the stroma. Furthermore, organisms were regularly seen either in close contact or existing inside the cytoplasm of neutrophils, suggesting the phagocytic role of these cells. No organism was found inside any endothelial cells or histiocytes.
Facial Erythema and Pigmentation as an Initial Manifestation of Chronic Graft‐versus‐Host Disease
Authors: Tokura Yoshiki , Yagi Hiroaki , Iwasaki Kayoko , Takigawa Masahiro 
Published: April 2015

AbstractTwo bone marrow transplant recipients developed chronic graft‐versus‐host disease, presenting with a mild erythematous, pigmented eruption only on the face three and ten months after transplantation. Histologically, the lesions showed liquefaction degeneration of basal keratinocytes and incontinence of melanin in the upper dermis with a mild infiltrate of T‐lymphocytes. These findings suggest that such a facial eruption occasionally may represent an initial manifestation of chronic GVHD.
Topical Treatment of Resistant Warts with Glutaraldehyde
Authors: Hirose Ryoji , Hori Makoto , Shukuwa Tetsuo , Udono Masako , Yamada Masao , Koide Takashi , Yoshida Hikotaro 
Published: April 2015

AbstractTherapy with glutaraldehyde (GA) was used to treat twenty‐five patients with selectively resistant warts. The patients were categorized as having one or more of the following conditions: 1) the location of the warts was either periungual, palmar or plantar, 2) the age of the patient was five years or younger, 3) the number of warts was two or more.ResultsEighteen (72%) out of twenty‐five cases were cured, and the other seven (28%) were not. The individual cure rates of the three conditions above were 80%, 60%, and 68.5% respectively. Pigmentary changes occurred immediately after the initial topical application of glutaraldehyde, and the surface of the verruca hardened. Soon afterwards some debris began to drop off of the verruca tissue little by little, and final healing was completed by less than twelve weeks without disagreeable marks. This therapy was found to be extremely useful, not only because the cure rate was high, but the following advantages were also noted: 1) no pain or pruritis, 2) no evidence of scarring or permanent pigmentary change, 3) good penetration in any location, 4) no need for special instruments or reagents except the solution, and 5) no special technique required (possible home treatment). This therapy is superior to cryotherapy (CT) in that it is useful for warts on any location, regardless of the number of lesions, and it is good for young children, although the cure rates for CT and GA are almost equal.
Childhood Cutaneous Melanoma
Authors: Bartoli Cesare , Bono Aldo , Zurrida Stefano , Clemente Claudio , Prato Ivan Del , Palo Giuseppe De , Cascinelli Natale 
Published: April 2015

AbstractSeventeen consecutive patients no older than 14 years with cutaneous melanoma were observed from 1975 to 1991 at the Istituto Nazionale Tumori, Milan; this series represented 0.8% of all cutaneous melanomas observed at the Institute during this period. Ten were males and seven females. Nine lesions arose on limbs, seven on the trunk, and one on the head and neck area. Reexamination of the clinical records suggests that childhood melanoma may present with unusual characteristics such as unusual appearance of the primary lesion and lack or scarcity of pigmentation. At first observation ten patients had stage I disease nine underwent surgery alone while in one surgery was performed in combination with regional lymph node dissection and chemotherapy. All the stage II patients underwent excision of the primary lesion and lymph node dissection. One of the 2 stage III patients received lymph node dissection only, and the other no treatment. Analysis of this series of 17 cases does not indicate that cutaneous melanoma in children is more aggressive than in adults. It is stressed that, although rare, the physician should be aware that cutaneous melanoma may occur in prepuberty.
Acute Febrile Neutrophilic Dermatosis (Sweet's Syndrome) Associated with Extreme Infiltration of Eosinophils
Authors: Masuda Toshiki , Abe Yoshiko , Arata Jirô , Nagao Yoh 
Published: April 2015

AbstractA remarkable infiltration of eosinophils was observed in skin biopsy specimens in two cases of Sweet's syndrome. One patient was a 29‐year‐old woman, whose clinical and histological features included associated asthma, a prior respiratory tract infection, red plaques, blood eosinophilia, and a dense dermal infiltrate of neutrophils and eosinophils, without evidence of vasculitis. The other patient was a 61‐year‐old man characterized by a fever, red plaques, erythema nodosum‐like lesions, hepatic dysfunction, a dermal infiltrate of neutrophils accompanied by eosinophils, and a subcutaneous prominent infiltrate of eosinophils. Clinical and histological evidence supported the diagnosis of Sweet's syndrome in both of these patients. While the literature describes eosinophil infiltration in this disease, extreme eosinophil infiltration could be misleading in the diagnosis.
Immunohistochemical Distribution of CD44 and Desmoplakin I & II in Hailey‐Hailey's Disease and Darier's Disease
Authors: Harada Masashi , Hashimoto Ken , Fujiwara Keiko 
Published: April 2015

AbstractThe cell‐surface glycoprotein CD44 is found on a wide variety of cells including epidermal cells. It is involved in cell to cell adhesion. Desmoplakin I & II are important components of the attachment plaque of desmosomes. In this study, we compared the distribution patterns of anti‐CD44 and anti‐desmoplakin I & II in Hailey‐Hailey's disease and Darier's disease. In the normal skin, anti‐CD44 stained the entire periphery of epidermal keratinocytes while anti‐desmoplakin I & II produced dotted staining patterns along the periphery of epidermal keratinocytes. In Hailey‐Hailey's disease and Darier's disease, the staining pattern of anti‐CD44 on acantholized keratinocytes did not change, but anti‐desmoplakin I & II lost their peripheral, dotted patterns and stained diffusely in the cytoplasm in most acantholytic cells. These results suggest that, in Hailey‐Hailey's disease and Darier's disease, CD44 may be intact even in acantholytic cells but abnormalities of desmoplakin exist in such cells.
Spectrum of Reticulate Flexural and Acral Pigmentary Disorders in Northern India
Authors: Dhar Sandipan , Kanwar Amrinder J. , Jebraili Roghieh , Dawn Goutam , Das Ashim 
Published: April 2015

AbstractReticulate pigmentary disorders are rare in India. Only 15 cases of reticulate acropigmentation of Kitamura (RAPK) and 9 cases of Dowling‐Degos disease (DDD) have been reported previously. To the best of our knowledge, there has been no earlier report of acropigmentation of Dohi. We herein describe 10 patients with various reticulate pigmentary abnormalitis: 6 with RAPK, 2 with DDD, 1 with RAPK‐DDD overlap, and 1 with acropigmentation of Dohi. Palmar pits and/or breaks in epidermal ridge pattern were absent in 2 of 6 patients with RAPK A 23‐year‐old male patient had RAPK‐DDD overlap. Periorbital pigmentation and pigmentation over the mucosal surface of the prepuce and corona of the glans penis were some unique features observed in this patient. His sister and mother had RAPK and DDD, respectively.We concluded that RAPK and DDD are varying manifestations of a single entity. Their presence in other family members probably depends on the degree of penetrance.
Oral Minocycline Improved Keratosis Follicularis Squamosa (Dohi) and Related Disorder: Bacterial Factors are Possibly Involved in Abberant Keratinization
Authors: Katayama Ichiro , Yokozeki Hiroo , Nishioka Kiyoshi 
Published: April 2015

AbstractThree cases of keratosis follicularis squamosa (Dohi) and one case of papillomatose confluente et reticulee were successfully treated with oral minocycline (50‐100 mg/day). The clinical effect first appeared at 2 weeks after the initiation of therapy and no recurrence was observed for more than 3 months without minocycline. Gram positive cocci were demonstrated inside the hair follicle and horny layers in all 4 case. Minocycline might modulate abberant keratinization through its bactericidal effects in these keratinizing disorders.
A Quantitative Study of Specific Immunoglobulins to Mosquito Salivary Gland Antigen in Hypersensitive and Common Types of Mosquito Bite Reaction
Authors: Ohtaki Noriko , Oka Keiko 
Published: April 2015

AbstractThis study was designed with two purposes: first, to elucidate immunologic mechanisms in different cutaneous reactions, particularly in hypersensitivity to mosquito bites, and, second, to develop a more reliable and safer method of identifying the causative species of mosquito in severe cases.The amounts of IgG, IgG4 and IgE specific to the mosquito salivary gland extract of Aedes albopictus were determined in the sera of 116 volunteers with normal reactions, either immediate or delayed, and 4 patients with severe systemic symptoms caused by mosquito bites. Titers of IgG and IgE in the severe cases were considerably higher than in volunteers with normal reactions, but there were no differences in IgG, titers between the two groups. These results indicate that high titers of IgG and IgE may be involved in development of systemic symptoms in severe cases and verify the possibility of in vitro tests to identify causative species of the mosquito.
Two Cases of Eosinophilic Pustular Folliculitis Treated by Acemetacin
Authors: Nishijima Setsuko , Sugiyama Tohru , Nakagawa Mitsuko , Odaka Tatsuo , Takaishi Kimiko 
Published: April 2015

AbstractThe report deals with two cases of eosinophilic pustular folliculitis in a 45‐year‐old man and a 25‐year‐old woman. After their conditions failed to respond to oral and topical corticosteroids, minocycline, anti‐allergic drugs, aspirin and several types of nonsteroidal anti‐inflammatory drugs, good results were obtained with acemetacin.