bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successional development of shrub-woody vegetation on natural river banks along certain watercourses in the Julian Alps and their foothills (western Slovenia and northeastern Italy)
Authors: Dakskobler Igor 
Published: July 2024

Abstract
We conducted a phytosociological survey of pioneer shrub and shrub-wood (brushwood) communities on river banks at the contact of gravel bars and rockfall, slope debris or colluvium in the spring area of the Nadiža River, in the gorge of the Soča River between Srpenica and Kobarid (Log Čezsoški and Magozd), in the Tolminka valley, and in certain other locations in the hills of western Slovenia. We identified a successional sequence of two grey willow and hop hornbeam communities, which we classify into the associations Salicetum eleagno-appendiculatae (Salicion eleagno-daphnoidis) and Peucedano verticillari-Ostryetum carpinifoliae (Fraxino orni-Ostryion). Both are indicators of natural river banks that have not been artificially stabilized. We expanded the knowledge of hop hornbeam communities in the pre-Alpine–northern-Dinaric part of Slovenia with a description of a new association Scopolio carniolicae-Ostryetum carpinifoliae. Its sites are characterised by slightly moist soil, and its stands by a higher proportion of species of the alliance Tilio-Acerion.
Differential expression of serum CXCL9 and CXCL10 levels in vitiligo patients and their correlation with disease severity and stability: A cross-sectional study
Authors: Aulakh Shayna , Goel Seema , Kaur Loveleen , Gulati Samridhi , Kaur Maninder , Chopra Dimple , Sarangal Rishu , Batra Jayati 
Published: July 2024

Background
Vitiligo is an acquired disorder of pigmentation with an elusive pathogenesis, though various theories have been proposed. The presence of peri-lesional autoreactive CD8+ T cell infiltrate suggests the involvement of abnormal immune responses and autoimmunity in vitiligo. Recent studies have identified the IFN-γ-CXCL9/CXCL-10 axis as a key component of the autoimmune response that perpetuates disease activity in vitiligo.

Objectives
The primary objective was to estimate serum CXCL9 and CXCL10 levels in vitiligo patients compared to age- and sex-matched controls. Additionally, the study aimed to find correlations between CXCL9 and CXCL10 levels and disease severity and stability. Secondary objectives included comparing levels in segmental/nonsegmental vitiligo and stable/progressive vitiligo and assessing the impact of age and gender.

Methods
A hospital-based cross-sectional study included 60 vitiligo patients and 30 age- and sex-matched controls. Serum levels of CXCL9 and CXCL10 were assessed using Enzyme-linked immunosorbent assay (ELISA). Cases were clinically evaluated for the type of vitiligo (segmental or non-segmental), disease severity (VASI score), and disease stability (VIDA score). Statistical analysis included t-tests, chi-square tests, and correlation coefficients. P value less than 0.5 was taken as significant.

Results
Serum CXCL9 and CXCL10, both, were significantly raised in vitiligo patients as compared to controls (p-value = 0.001* & 0.001* respectively) and correlated positively with both VASI score (p-value = 0.001* & 0.001* respectively) and with VIDA score (p-value = 0.032* & 0.001* respectively). Serum CXCL10 showed significant elevation in progressive vitiligo, and CXCL9 exhibited a non-significant trend. No significant difference was observed between segmental and non-segmental vitiligo. Both chemokines positively correlated with disease severity and stability, while age and gender did not significantly impact chemokine levels.

Limitations
Small sample size of control population. The voluntary sampling technique led to an unequal number of patients in progressive and stable vitiligo groups, as well as in segmental and non-segmental groups. The current study did not include blister fluid analysis and the effect of therapy on the chemokine levels.

Conclusion
The expression of chemokines CXCL9 and CXCL10 is markedly increased and correlates positively with disease severity and instability, underscoring their mechanistic role in vitiligo pathogenesis. The values were also higher in the progressive group than in the stable group, inferring their conceivable potential as serum biomarkers.
*represents statistically significant results
Sistem Perpustakaan Menggunakan QR Code Berbasis Web Dengan Framework Codeigniter
Authors: Adhiwibowo Whisnumurti , Mahmud Ghozali 
Published: July 2024

<p>Perpustakaan SD Negeri Muktiharjo Lor merupakan lembaga pendidikan yang memiliki kumpulan bahan pustaka yang lengkap. Dari koleksi buku pelajaran maupun kumpulan buku-buku umum di sediakan kepada para pengunjung perpustakaan. Dalam proses kerjanya yaitu proses simpan pinjam bahan pustaka masih dilakukan secara manual tanpa memanfaatkan sebuah sistem informasi guna meningkatkan kinerja layanan para pustakawan atau pengelola. Kondisi tersebut menjadi dasar dalam merancang bangun sistem perpustakaan menggunakan <em>QR Code</em> Berbasis Web dengan <em>Framework</em> <em>Codeigniter</em>. Metode <em>Waterfall</em> digunakan dalam membuat pengembangan sistem, <em>codeignite</em>r digunakan dalam pembuatan <em>framework</em>, dan MySQL digunakan untuk menyimpanan database. Sistem yang dibangun di SD Negeri Muktiharjo Lor mampu dalam meningkatkan kinerja layanan perpustakaan baik dalam keefesien, keefektifan dan dapat mengurangi kesalahan-kesalahan dalam mengolah bahan pustaka karena menggunakan <em>QR Code.</em></p><p><em><em>The SD Negeri Muktiharjo Lor library is an educational institution that has a complete collection of library materials. From the collection of textbooks and a collection of general books provided to library visitors. In the work process, the process of saving and borrowing library materials is still done manually without using an information system to improve the service performance of librarians or managers. This condition is the basis for designing a library system using a Web-based QR Code with Codeigniter Framework. The Waterfall method is used in making system development, Codeigniter is used in making the framework, and MySQL is used for storing databases. The system built at SD Negeri Muktiharjo Lor can improve the performance of library services both in efficiency, effectiveness and can reduce errors in processing library materials because it uses QR Code.</em></em></p><p class="BasicParagraph"><em>Keywords: </em><em><em><em>QR Code; Muktiharjo Lor Elementary School; Library</em></em></em></p>
PENGARUH PERSEPSI HARGA DAN KUALITAS PELAYANAN PADA KEPUASAN PELANGGAN DENGAN CITRA MEREK SEBAGAI VARIABEL INTERVENING
Authors: Darojah Rofiatu , Widjajanti Kesi , Kuswardani DC 
Published: July 2024

<p>Penelitian ini dilakukan di Agen Resmi Bus Patas AC/Executive PO. Ramayan, Semarang. Tujuan Penelitian ini adalah untuk mengetahui pengaruh persepsi harga, kualitas layanan terhadap kepuasan pelanggan dengan citra merek sebagai variabel intervening. Populasi dan sampel penelitian ini adalah penumpang Bus Patas AC/Executive PO. Ramayana. Jumlah responden sebagai sampel dalam penelitian ini sebanyak 100 responden. Analisis data berupa uji validitas, uji reliabilitas, uji normalitas, uji heterokedatisitas, uji multikorelas, uji linearitas, analisis regresi berganda, uji koefisien determinan, uji F, dan uji t. Hasil penelitian ini menunjukkan bahwa persepsi harga berpengaruh signifikan terhadap kepuasan pelanggan. Kualitas layanan berpengaruh signifikan terhadap kepuasan pelanggan. Variabel citra merek signifikan memediasi pengaruh variabel persepsi harga (X1) terhadap varaibel kepuasan pelanggan (Y2).</p><p> </p><p><em>This research was conducted at the Patas AC/Executive PO Bus Authorized Agent. Ramayan, Semarang. The purpose of this study was to determine the effect of price perception, service quality on customer satisfaction with brand image as an intervening variable. The population and sample of this study were Patas AC/Executive PO Bus passengers. Ramayana. The number of respondents as a sample in this study were 100 respondents. Data analysis in the form of validity test, reliability test, normality test, heteroscedasticity test, multicorrelation test, linearity test, multiple regression analysis, determinant coefficient test, F test, and t test. The results of this study indicate that price perception has a significant effect on customer satisfaction. Service quality has a significant effect on customer satisfaction. The brand image variable significantly mediates the effect of the price perception variable (X1) on the customer satisfaction variable (Y2)</em></p>
Concomitant Ozaki procedure and septal myectomy in patients with severe aortic stenosis
Authors: Kobzev E. E. , Karpov I. A. , Rosseikin E. V. 
Published: July 2024

Objective. The presence of marked asymmetric septal hypertrophy in patients with aortic stenosis may lead to dynamic obstruction of the left ventricular outflow tract in addition to fixed obstruction at the level of the aortic valve. The persistence of an increased subvalvular gradient may worsen both early and long-term results. At the same time, surgical tactics in combination of two pathologies is currently undefined.Aim: To analyze the early and mid-term results of concomitant Ozaki procedure and septal myectomy.Patients and Methods. This case series included 13 patients with severe aortic stenosis and asymmetric septal hypertrophy who underwent aortic valve reconstruction according to the Ozaki technique and septal myectomy according to Morrow. The mean age was 68 years [from 50 to 79]. In 12 of 13 patients, the aortic valve annulus was less than 21 mm. Early and mid-term (29.5 months) clinical results, complications specific for septal myectomy, hemodynamic parameters at the aortic valve and left ventricular outflow tract were evaluated.Results. 1 patient died at the hospitalization stage. There were no cases of repeated aortic clamping for aortic valve prosthesis, additional resection of interventricular septum, acute defect of interventricular septum. One patient required permanent pacing due to complete transverse heart block. There were no lethal outcomes during the follow-up. Good hemodynamic results were achieved in all patients: mean aortic valve area 2.2 cm2 (from 1.4 to 3.0 cm2 ); mean transvalvular gradient 11 mmHg (from 6 to 15 mmHg); basal interventricular septum thickness 11.2 mm, left ventricular outflow tract gradient 3.9 mmHg.Conclusion. In our case series of 13 patients with aortic stenosis and subvalvular left ventricular outflow tract obstruction, Ozaki procedure and septal myectomy resulted in good early and mid-term clinical and hemodynamic outcomes. Septal myectomy is a safe procedure without increasing the risk of complications. However, large prospective randomized comparative studies are needed to provide reliable evidence of the benefit of combined intervention and to develop optimal recommendations.
Tendencies and features of cerebral stroke mortality according to the data of Tomsk Regional Vascular Center
Authors: Alifirova V. M. , Boykov V. A. , Plotnikov D. M. , Naydenova N. E. , Nagaitsev A. V. , Protasova L. M. , Stasyuk N. A. , Amonotidi A. V. , Shirykalov G. M. , Dmitrieva Y. S. 
Published: July 2024

Introduction. In Tomsk Region specialized medical care for the patients with acute cerebrovascular disorders has been provided and coordinated since 2012 by the Regional Vascular Center of Tomsk Regional Clinical Hospital where more than three-quarters of all stroke patients in the region are admitted annually.Aim: To study the dynamics of mortality rates in different nosological forms of stroke, gender and age characteristics of the patients who died from stroke, the example of the work of the Regional Vascular Center of Tomsk Regional Clinical Hospital being used, and to determine the directions for further improvement of medical care organization.Materials and Methods. At the first stage, the assessment of the dynamics of mortality rates from different nosological forms of stroke in Tomsk Regional Clinical Hospital according to the Federal Statistical Observation Form No. 14 from 2018 to 2022 was performed. At the second stage of the study, based on data from registration form No. 066/u of the Regional Vascular Center, the structure of gender and age of the patients who died from stroke was analyzed, the average age of death of the patients with stroke, their gender and age characteristics, taking into account the form of stroke, were determined.Results. Mortality rates from stroke in Tomsk Regional Clinical Hospital were relatively stable and quite high – 23.6–24.8%; the greatest fluctuations in mortality rates (36.0–59.6%) and (46.7–56.9%) were observed in hemorrhagic forms. The average age of death from stroke in men at the Regional Vascular Center was 12 years lower than in women – 67.0 (59.0–76.0) years. Distinct gender differences were revealed among deceased patients with a significant predominance of men – 73.0 and 68.6% in the age groups 18–44 years and 45–59 years.Conclusion. Directions for further improvement of medical care organization have been identified: opening an additional vascular center, developing mechanisms for timely re-evacuation of patients, optimizing the system for managing stroke risk factors.
Mid-term hemodynamic results of bioprosthetics of the aortic valve with a prosthesis with a unique “easy change” system
Authors: Ergashev Sh. S. , Petlin K. A. , Alyamkin V. E. , Chernykh Y. N. , Kozlov B. N. 
Published: July 2024

Aim: To assess the hemodynamic results of using the xenopericardial biological prosthesis “MedEng-BIO” with the “easy change” system in the aortic position in the mid-term period.Material and Methods. In the cardiac surgery department No. 1 of Cardiology Research Institute, Tomsk NRMC, from October 2016 to January 2024, 341 patients (155 women and 186 men) underwent aortic valve replacement surgery using an innovative “MedEng-BIO” bioprosthesis with the “easy change” system. The average age of the patients was 67.6 ± 6.6 years. The study included 190 patients (88 women and 102 men) who underwent aortic valve replacement using the innovative “MedEng-BIO” bioprosthesis with the “easy change” system in the period from January 2017 to January 2022. The average age of the patients was 67.6 ± 6.6 years. The average pressure gradient on the aortic valve before surgery was 48.2 ± 13.5 mmHg. The effective area of the aortic valve opening averaged (EАO) – 0.72 ± 0.2 cm2 . Control echocardiographic studies of left ventricular (LV) function and aortic bioprosthesis after surgery were performed on the 10th–14th day after surgery and 3–5 years after discharge using Vivid 7, GE and IE 33 (Philips) devices.Results. Control echocardiographic studies conducted in the mid-term period allowed us to establish that the hemodynamic characteristics of “MedEng-BIO” aortic prostheses in the aortic position remain satisfactory. The average pressure gradient on the “MedEng-BIO” prostheses of 21 sizes was 22.6 mmHg, 23 with a size of – 15.1 mmHg and 25 with a size of 10.3 mmHg.Conclusion. Based on the data obtained, it can be concluded that xenopericardial “MedEng-BIO” bioprostheses with the “easy change” system correct intracardiac hemodynamics well over a follow-up period of more than 3 years and show no signs of degeneration.
Implementasi Kurikulum Merdeka pada Pembelajaran Bahasa Indonesia Kelas X di SMK Negeri 1 Sedayu
Authors: Rohmah Azizah Nuzulul , Esti Swatika Sari  
Published: July 2024

SMK Negeri 1 Sedayu merupakan salah satu SMK Pusat Keunggulan di Daerah Istimewa Yogyakarta yang mengimplementasikan Kurikulum Merdeka. Tujuan penelitian ini, yaitu mendeskripsikan dan menjelaskan (1) perencanaan, (2) implementasi, serta (3) kendala dan upaya yang dilakukan oleh pendidik mata pelajaran Bahasa Indonesia dalam mengimplementasikan Kurikulum Merdeka pada pembelajaran Bahasa Indonesia kelas X di SMK Negeri 1 Sedayu. Penelitian ini menggunakan pendekatan deskriptif kualitatif. Hasil dari penelitian ini menunjukkan bahwa (1) perencanaan Kurikulum Merdeka telah dilakukan dengan adanya modul ajar yang mengacu pada Capaian Pembelajaran Bahasa Indonesia Fase E, (2) implementasi Kurikulum Merdeka dilihat dari aspek materi, model, media, dan penilaian pembelajaran yang digunakan sudah sesuai dengan perencanaan pembelajaran meskipun terdapat unsur-unsur dalam modul ajar yang terlewat tidak dilaksanakan, (3) terdapat dua kendala yang ditemukan, serta (4) upaya-upaya dilakukan oleh pendidik untuk mengatasinya.
Kata Kunci: implementasi kurikulum, kelas X, Kurikulum Merdeka, pembelajaran Bahasa Indonesia, SMK.
Experience in the production and clinical application of the cell-based medicinal product Easytense® for the repair of cartilage defects of the human knee
Authors: Zoricheva A. S. , Zvonova E. A. , Agapova L. S. , Lykova M. S. , Markova O. A. , Leonov V. S. 
Published: July 2024

INTRODUCTION. The current cell-based cartilage repair methods, such as autologous chondrocyte transplantation, are not sufficiently effective, and the surgery is painful and traumatic. Therefore, there is a need for a more effective cell therapy product with a minimally invasive surgical procedure for its implantation into the patient.AIM. This study aimed to develop a manufacturing technology for the production of an autologous cell-based medicinal product (CBMP) comprising three-dimensional structures (3D-spheroids) based on chondrocytes isolated from the patient’s cartilage tissue, as well as to evaluate its clinical efficacy.MATERIALS AND METHODS. Autologous chondrocytes isolated from the patient’s cartilage biopsy were propagated in monolayer culture to obtain the required number of cells. Subsequently, the chondrocytes were cultivated on plates with a non-adhesive coating to form 3D spheroids. All CBMP production steps were performed under aseptic conditions in cell culture isolators. The authors used phase-contrast microscopy and immunohistochemical staining with specific fluorescence-labelled antibodies to characterise chondrocyte phenotypes at different stages of cultivation. Genetic stability was controlled by karyotyping. The efficacy of Easytense® was evaluated in a clinical trial using specialised functional tests and the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score. The primary efficacy endpoint was a change in the overall score on the Knee Injury and Osteoarthritis Outcome Score (KOOS).RESULTS. A manufacturing technology without using animal sera, growth factors, cytokines, or other additives was developed for the production of the autologous CBMP Easytense®. Karyological data confirmed that the chondrocytes retained genetic stability for 3 passages in monolayer culture. When cultured as 3D spheroids, the chondrocytes produced cartilage extracellular matrix proteins (type II collagen, aggrecan), thus acquiring the ability to repair damaged cartilage. The clinical trial demonstrated a statistically significant improvement in knee cartilage 12 months after the transplantation of 3D spheroids derived from autologous chondrocytes. The mean change in the overall KOOS score was 23.8±15.9.CONCLUSIONS. The clinical trial results indicate that Easytense® is highly effective for cartilage repair. Based on these results, the CBMP has been granted marketing authorisation and introduced into clinical practice in the Russian Federation. Easytense® has the potential to replace endoprosthetics and expensive surgeries abroad.
De la démocratie autoritaire, en France et ailleurs
Authors: Ory Pascal 
Published: July 2024

L’assimilation du démocratique au libéral est une théorie que l’Histoire dément, depuis, au moins, l’Antiquité grecque des « tyrans ». Les Modernes confirment, après cinq siècles d’expérimentation politique : la Souveraineté du « Peuple » a produit un type d’idéologie (populiste) et deux types d’institutions (la démocratie autoritaire et la démocratie totalitaire) qui, aujourd’hui, dominent la majorité des « peuples ».
Fake News and Hate Speech in Nigeria's Development and Security Trajectory: A Qualitative Assessment
Authors: Liadi Olusegun Fariudeen , Lawal Musediq Olufemi , Akinrinde Olawale Olufemi 
Published: July 2024

The proliferation of false news and hate speech in Nigeria is posing a severe barrier to information sharing. The ease with which people now propagate destructive views across numerous social platforms complicates the situation even further. Despite multiple studies on the subject in Nigeria, what drives the spread of false news and hate speech and how it affects the country's security and prosperity remain elusive in the existing literature. This study, therefore, seeks to address that vacuum by delving deeply into the complex dynamics behind these concerns in Nigeria and investigating how they influence the country's security and prosperity. To grasp the entire scale of false news and hate speech, this study conducted extensive research that included reviewing old documents and conducting in-depth interviews with a varied range of people. The findings of this study indicated that young people are more exposed to the negative consequences of false news and hate speech. The pull of social media and its active debates frequently draws children into situations where they are more likely to encounter incorrect and nasty remarks. Recognizing youth as a significant demographic affected by this issue is critical. It implies that the government must take specific action to address the underlying causes and repercussions of false news and hate speech in Nigeria. This study, as a result, emphasizes the critical necessity for proactive actions to defend Nigeria's news and information-sharing procedures and platforms. Policymakers may aid Nigerian society by enacting legislation and protections to prevent the detrimental impact of fake news and hate speech. Ultimately, these initiatives can result in a more educated and inclusive public discussion.