bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of ethylene‐octene copolymer and ethylene‐propylene copolymer on crystallization, morphology, and foaming properties of ethylene‐vinyl acetate copolymer
Authors: Wang Yuanxia , Hao Qi , Zou Cun‐Ying , Bai Nan , Su Qun‐Feng , Zhang Chen‐Guang , Wan Yu‐Jiang , Shen Jia‐Qi , Song Li‐Xin , Li Xian‐Liang , Liu Li‐Zhi 
Published: August 2024

AbstractEthylene‐octene copolymer (EOC, three EOCs with different octene content used in this study) and propene‐ethylene copolymer (EPC, three EPCs with different ethylene content used in this study) can have effects on the crystallization dynamics, crystal structure, and foaming properties of ethylene‐vinyl acetate copolymer (EVA). For unfoamed EVA/EOC and unfoamed EVA/EPC blends, both EVA/EOC and EVA/EPC blends show phase separation structure. The foam cells in EVA/EOC blends have better uniformity compared to those in EVA/EPC blends, which result from the better compatibility of EVA and EOC than EVA and EPC obtained from the morphology analysis. For the blends with different crystallization ability of EOC or EPC, the blends with lower crystallinity has more uniform cell distribution than blends with higher crystallinity, due to the crystallization zone cause heterogeneous crosslinking and foaming of the blend. Both EOC and EPC can impart higher elasticity to EVA foamed materials. EOC was found to be more suitable for blending with EVA for foamed materials, offering the potential to obtain EVA/EOC foamed materials with excellent performance.Highlights
Ethylene‐octene copolymer with higher octene content has better effect on foaming property of ethylene‐vinyl acetate copolymer than ethylene‐propylene copolymer.
Ethylene‐propylene copolymer can decrease the foaming temperature of ethylene‐vinyl acetate copolymer.
A mechanism of foaming for ethylene‐vinyl acetate copolymer/semi‐crystallized polymer blends is proposed.
Achieved in‐depth understanding of structure–property relationship about ethylene‐vinyl Acetate copolymer/polyolefin elastomer foamed material.
Simulated herbicide mixtures delay both specialist monogenic and generalist polygenic resistance evolution in weeds
Authors: Renton Michael , Willse Alan , Aradhya Chandrashekar , Tyre Andrew , Head Graham 
Published: August 2024

AbstractBACKGROUNDEvolution of herbicide‐resistant weed populations is a major challenge to world food production. Using different herbicides in rotation and/or using different herbicides together as mixtures are strategies that may delay the selection of resistance. This study used simulation modelling to investigate whether mixtures and rotations can delay the selection of both generalist polygenic and specialist monogenic herbicide resistance, and whether these strategies are more likely to lead to the selection of generalist resistance in weed types with varying biological characteristics.RESULTSOur simulations suggest that well‐designed effective herbicide mixtures should delay evolution of both polygenic and monogenic resistance better than rotations and single herbicides across all weed types. Both mixture and rotation strategies increased the likelihood of polygenic resistance compared to single‐herbicide use, and the likelihood of polygenic resistance increased as the fecundity and competitiveness of the weed increased. Whether monogenic or polygenic resistance occurred in each case depended most on the relative initial allele frequencies. We did not find that herbicide mixtures were more likely than rotations to lead to the selection of generalist polygenic resistance. The simulated efficacy of mixtures over rotations decreased if components were used at reduced rates or when individual components had already been used solo.CONCLUSIONHerbicide rotations and particularly well‐designed mixtures should delay evolution of both polygenic and monogenic resistance, especially if used as part of an effective integrated weed management programme. However, herbicide mixtures and rotations may also increase the risk that resistance will be generalist polygenic rather than specialist monogenic. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Control efficacy and joint toxicity of broflanilide mixed with commercial insecticides to an underground pest, the black cutworm in highland barley
Authors: Wang Yingnan , Zhan Enling , Lu Hui , Chen Yiqu , Duan Fenglei , Wang Ying , Tang Tao , Zhao Chunqing 
Published: August 2024

AbstractBACKGROUNDThe highland barley, Hordeum vulgare L., is a staple food crop with superior nutritional functions in Xizang, China. It is often damaged by the black cutworm, Agrotis ipsilon (Hufnagel), which is an underground pest and difficult to effectively manage. To introduce a novel insecticide with unique mode of action, broflanilide (BFL) and its binary mixtures with chlorantraniliprole (CAP), fluxametamide, β‐cypermethrin or imidacloprid were screened out as seed treatment to control black cutworm in highland barley in the present study.RESULTSIn the laboratory bioassays, BFL had outstanding insecticidal activity to black cutworm with a median lethal dose (LD50) of 0.07 mg kg−1. The mixture of BFL × CAP at the concentration ratio of 7:40 exhibited the highest synergistic effect with a co‐toxicity coefficient of 280.48. In the greenhouse pot experiments, BFL and BFL × CAP seed treatments at 8 g a.i. kg−1 seed could effectively control black cutworm, with a low percentage of injured seedlings <20% and high control efficacies of 93.33–100% during a period of 3–12 days after seed emergence. Moreover, BFL and BFL × CAP seed treatments could promote the seed germination and seedling growth of highland barley at the tested temperatures of 15, 20 and 25 °C.CONCLUSIONOur results indicated that BFL and BFL × CAP were effective and promising insecticides as seed treatment to control black cutworm in highland barley. © 2024 Society of Chemical Industry.
Protective Effects of Syringic Acid Against Oxidative Damage, Apoptosis, Autophagy, Inflammation, Testicular Histopathologic Disorders, and Impaired Sperm Quality in the Testicular Tissue of Rats Induced by Mercuric Chloride
Authors: Akarsu Serkan Ali , Gür Cihan , Küçükler Sefa , Akaras Nurhan , İleritürk Mustafa , Kandemir Fatih Mehmet 
Published: August 2024

ABSTRACTMercury (Hg) is one of the most toxic heavy metals that damage testicular tissue. Mercury chloride (HgCl2) is one of the most toxic forms of mercury that can easily cross biological membranes. Syringic acid (SA) is a natural flavonoid found in many vegetables and fruits. In this study, the effects of SA against HgCl2‐induced testicular damage in rats were determined by biochemical, histopathological, and spermatological analyses. For this study, a total of 35 Spraque Dawley rats were used. Rats were divided into five groups as control, HgCl2, SA 50, HgCl2 + SA 25, and HgCl2 + SA 50. HgCl2 was administered intraperitoneal (IP) at a dose of 1.23 mg/kg/bw, while SA was administered by oral gavage at doses of 25 and 50 mg/kg/bw. The rats were then sacrificed, and testicular tissues were removed. HgCl2 caused an increase in MDA level and a decrease in SOD, CAT, and GPx activity and GSH level in the testicular tissue of rats. HgCl2 is involved in the increase of eIF2‐α, PERK, ATF‐4, ATF‐6, CHOP, NF‐κB, TNF‐α, IL‐1β, Apaf‐1, Bax, and Caspase‐3 mRNA expression. HgCl2 caused a decrease in sperm motility, an increase in the rate of abnormal sperm and sperm DNA fragmentation in rats. However, SA oral administration dose‐dependently inhibited endoplasmic reticulum stress, oxidative stress, inflammation, and apoptosis and preserved epididymal sperm quality and testicular histoarchitectures. In conclusion, SA had protective effects against HgCl2‐induced testicular oxidative damage, inflammation, endoplasmic reticulum stress, and apoptosis.
The genus Aglaia: Diversity in chemical structure and biological activity
Authors: Bang Ngo Anh , Tai Bui Huu , Yen Pham Hai , Kiem Phan Van 
Published: August 2024

AbstractThe Meliaceae family has been investigated comprehensively because of their structurally multifarious, and biologically active components. The genus Aglaia has the highest amount in this family, including around 150 species. These species are widespread throughout tropical regions, particularly in Southeast Asia and Australia. They have been used in traditional medicine for treating various diseases. This article summarizes 370 metabolites, which have been isolated from several parts such as the bark, roots, seeds, and leaves of Aglaia species in over fifty years from the first investigation in 1965 to 2024, originating from the flavagline, triterpenoid, sesquiterpenoid, steroid, alkaloid, and limonoid, while flavagline is the largest group. The components isolated from the genus Aglaia are analyzed for potential biological activities, like cytotoxicity, anti‐inflammatory, insecticidal, antiviral, antituberculosis, and antifungal effects. In addition, the flavagline was reported to show a high potential for cytotoxic and insecticidal activities and was confirmed to be used as the chemical marker for this species. Therefore, these reports indicate that Aglaia species may hold potential as a valuable source for producing biologically active compounds.
A hybrid approach to improvement of watershed water quality modeling by coupling process–based and deep learning models
Authors: Jeong Dae Seong , Jeong Heewon , Kim Jin Hwi , Kim Joon Ha , Park Yongeun 
Published: August 2024

AbstractWatershed water quality modeling to predict changing water quality is an essential tool for devising effective management strategies within watersheds. Process‐based models (PBMs) are typically used to simulate water quality modeling. In watershed modeling utilizing PBMs, it is crucial to effectively reflect the actual watershed conditions by appropriately setting the model parameters. However, parameter calibration and validation are time‐consuming processes with inherent uncertainties. Addressing these challenges, this research aims to address various challenges encountered in the calibration and validation processes of PBMs. To achieve this, the development of a hybrid model, combining uncalibrated PBMs with data‐driven models (DDMs) such as deep learning algorithms is proposed. This hybrid model is intended to enhance watershed modeling by integrating the strengths of both PBMs and DDMs. The hybrid model is constructed by coupling an uncalibrated Soil and Water Assessment Tool (SWAT) with a Long Short‐Term Memory (LSTM). SWAT, a representative PBM, is constructed using geographical information and 5‐year observed data from the Yeongsan River Watershed. The output variables of the uncalibrated SWAT, such as streamflow, suspended solids (SS), total nitrogen (TN), and total phosphorus (TP), as well as observed precipitation for the day and previous day, are used as training data for the deep learning model to predict the TP load. For the comparison, the conventional SWAT model is calibrated and validated to predict the TP load. The results revealed that TP load simulated by the hybrid model predicted the observed TP better than that predicted by the calibrated SWAT model. Also, the hybrid model reflects seasonal variations in the TP load, including peak events. Remarkably, when applied to other sub‐basins without specific training, the hybrid model consistently outperformed the calibrated SWAT model. In conclusion, application of the SWAT‐LSTM hybrid model could be a useful tool for decreasing uncertainties in model calibration and improving the overall predictive performance in watershed modeling.Practitioner points
We aimed to enhance process‐based models for watershed water‐quality modeling.
The Soil and Water Assessment Tool‐Long Short‐Term Memory hybrid model's predicted and total phosphorus (TP) matched the observed TP.
It exhibited superior predictive performance when applied to other sub‐basins.
The hybrid model will overcome the constraints of conventional modeling.
It will also enable more effective and efficient modeling.
Effect of an Intrapartum Pelvic Dilator Device on Levator Ani Muscle Avulsion During Primiparous Vaginal Delivery: A Pilot Randomized Controlled Trial
Authors: Hesham Helai , Orejuela Francisco , Rood Kara M. , Turrentine Mark , Casey Brian , Khandelwal Meena , Dajao Rori , Azad Sarah , Rosen Todd , Hoffman Matthew K. , Wang Eileen Y. , Hart Laura , Sheen Jean-Ju , Grisales Tamara , Gibson Kelly S. , Torbenson Vanessa , Williams Shauna F. , Evantash Edward , Dietz Hans P. , Wapner Ronald J. 
Published: August 2024

Abstract
Introduction and Hypothesis
The objective was to evaluate the safety and effectiveness of an intrapartum electromechanical pelvic floor dilator designed to reduce the risk of levator ani muscle (LAM) avulsion during vaginal delivery.

Methods
A multicenter, randomized controlled trial enrolled nulliparous participants planning vaginal delivery. During the first stage of labor, participants were randomized to receive the intravaginal device or standard-of-care labor management. The primary effectiveness endpoint was the presence of full LAM avulsion on transperineal pelvic-floor ultrasound at 3 months. Three urogynecologists performed blinded interpretation of ultrasound images. The primary safety endpoint was adverse events (AEs) through 3 months.

Results
A total of 214 women were randomized to Device (n = 113) or Control (n = 101) arms. Of 113 Device assignees, 82 had a device placed, of whom 68 delivered vaginally. Of 101 Control participants, 85 delivered vaginally. At 3 months, 110 participants, 46 Device subjects who received full device treatment, and 64 Controls underwent ultrasound for the per-protocol analysis. No full LAM avulsions (0.0%) occurred in the Device group versus 7 out of 64 (10.9%) in the Control group (p = 0.040; two-tailed Fisher’s test). A single maternal serious AE (laceration) was device related; no neonate serious AEs were device related.

Conclusions
The pelvic floor dilator device significantly reduced the incidence of complete LAM avulsion in nulliparous individuals undergoing first vaginal childbirth. The dilator demonstrated an acceptable safety profile and was well received by recipients. Use of the intrapartum electromechanical pelvic floor dilator in laboring nulliparous individuals may reduce the rate of LAM avulsion, an injury associated with serious sequelae including pelvic organ prolapse.
Ninth Pharmacologic-Historical Forum, 2024, Munich, Germany: the development of experimental pharmacology in Munich at the Walther Straub Institute
Authors: Eyer Peter 
Published: August 2024

Abstract
In 1887, Hermann Tappeiner (1847–1927) was appointed as professor for medicinal chemistry and pharmacology. He studied the role of intestinal bacteria and contributed to better understanding of digestion. In 1923, Walther Straub (1874–1944) succeeded. He was at the zenith of his scientific career, gained habilitation in Leipzig already in 1900, accepted the direction of the Institute of Pharmacology at Marburg in 1905, of Würzburg in 1906, before he moved to Freiburg in 1907. Straub preferred quantitative studies with various alkaloids, cardiac glycosides, and Senna glycosides on isolated organs. One important legacy is his contribution “Die Digitalisgruppe” in Hefters Handb. Exp. Pharmakol. 1924. Walther Straub was editor of Naunyn–Schmiedeberg’s Archives of Pharmacology and founded the Deutsche Pharmakologische Gesellschaft in 1920. In 1944 when most of the institute was destroyed by air raids, Walther Straub retired and succumbed in Bad Tölz. In 1946, August Wilhelm Forst (1890–1981), a pupil of Straub, was appointed to head the institute ruins. We owe to him the provisional reconstruction of the old building, institution of an Insulin Control Laboratory, and the development of a vibratory cage that allowed the registration of psychomotor activity in rodents. Forst published the first comprehensive review on “Detoxication.” In 1961, Manfred Kiese (1910–1983), a pupil of W. Heubner, came from Tübingen and accompanied the erection of a new building. Kiese made important contributions to the understanding of the biotransformation of foreign compounds and was the first to describe the biological N-oxygenation. His studies on ferrihemoglobin formation resulted in the development of an effective cyanide antidote, 4-dimethylaminophenol. “Methemoglobinemia, a Comprehensive Treatise” is part of his scientific legacy. In 1980, Wolfgang Forth (1932–2009) from Bochum headed the institute and convinced the medical faculty of LMU to rename the building into Walther Straub Institute. His scientific interests were centered on interactions between essential and toxic metals during intestinal absorption. He was co-editor of the German Textbook on Pharmacology and Toxicology founded in 1975, which is presently in its 13th edition. In 2000, Peter Eyer (1942) was commissioned to lead the institute until Thomas Gudermann (1960) was appointed to direct the chair in 2008.
Successful rechallenge with azacytidine and venetoclax after sustained treatment-free remission in a relapsed acute myeloid leukemia patient: a case report
Authors: Tamellini E. , Simio C. , Bernardelli A. , Ferrarini I. , Vatteroni A. , Moioli A. , Macaluso V. , Marchetti E. , Tanasi I. 
Published: August 2024

AbstractCombined therapy with venetoclax and hypomethylating agents has significantly improved the outcome of unfit patients ineligible for intensive chemotherapy. A recently published exploratory analysis of the VIALE-A trial reported that up to 51% of patients achieving remission survived more than 2 years. These data along with those from reallife settings, lead to questioning how long it is appropriate to continue treatment in long-term survivors. Accordingly, recent retrospective studies suggested the feasibility of suspending therapy in selected patients while maintaining prolonged responses. Also, these studies showed that retreatment may induce a second remission in almost a third of patients. We report the case of a patient who received salvage therapy with venetoclax and azacytidine, that was discontinued few cycles after blasts clearance because of severe hematological toxicity. Despite suspension, he maintained a sustained response lasting almost one year and was successfully retreated with the same combination when a second relapse occurred.
Transvaginal morcellation within an enclosed bag in gynecological surgeries: a comprehensive systematic review and analysis of safety, efficacy, and outcomes
Authors: Alomari Omar , Mokresh Muhammed Edib , Muvaffak Emir , Bakir Rahime Nurbanu , Al Shomali Raghad , Akis Serkan , Acar Sami , Api Murat 
Published: August 2024

Abstract
Purpose
This systematic review aims to comprehensively assess the safety and efficacy of transvaginal morcellation within an enclosed bag in gynecological surgeries, with a focus on its benefits, potential risks, and recommendations for its use.

Methods
We conducted a comprehensive search of Epistemonikos, Web of Science, Medline (PubMed), Scopus, and Cochrane databases for studies on transvaginal contained morcellation in adult patients undergoing gynecological surgeries. The review included 22 studies that met the inclusion criteria, encompassing diverse surgical procedures, patient profiles, and outcomes. These studies were thoroughly reviewed and analyzed to assess the safety and efficacy of the morcellation technique.

Results
Key findings from the selected studies indicate that transvaginal morcellation within an enclosed bag offers several advantages in gynecological surgeries, including reduced invasiveness, shorter operative times, and minimal blood loss when compared to conventional methods. The risk of tumor recurrence or dissemination appears to be low when appropriate precautions are taken, emphasizing the technique’s safety, especially when performed by experienced surgical teams. While some studies reported complications, these were generally not directly associated with the morcellation technique.

Conclusion
Transvaginal morcellation within an enclosed bag demonstrates potential as a safe and effective option for gynecological surgeries. The technique offers the benefits of minimally invasive procedures, including reduced bleeding, shorter recovery times, and improved cosmetic outcomes. This review also highlights the need for standardization in study methodologies and reporting, as the heterogeneity in outcomes across the selected studies poses challenges in drawing definitive conclusions.
Action inhibition in a sport-specific paradigm: examining the limits of action control in basketball
Authors: Wickemeyer Carolin , Güldenpenning Iris , Weigelt Matthias 
Published: August 2024

AbstractTo investigate the point where inappropriate defensive movements can no longer be inhibited and to validate suitable stimulus material for constructing a basketball-specific anticipation-response-inhibition task, two experiments were conducted. In Experiment 1, participants without basketball expertise (N = 25) watched a video of a basketball jump shot and were asked to release the space bar at the point when the ball leaves the player's fingertips (go-trials). In 25% of all trials, the video was stopped prematurely and participants should withhold their finger-lift response (stop-trials). A staircase-tracking algorithm was used to adjust the point-in-time when the jump shot was stopped in a way that participants’ inhibition rate was at 50% (reflecting the so called “point-of-no-return”, PNR). In Experiment 2, the stimulus material was adapted so that stop-trials simulated a pump fake. The PNR in Experiment 1 was located 187 ms and in Experiment 2 177 ms before the point of ball release. Precision performance benefit from practice across blocks and participants delayed their responses after stop-trials in a subsequent go-trial, which reflects strategic post-stop-trial adjustments. Based on the comparable results of previous studies, the given stimulus material is suitable for investigating response inhibition skills in dynamic sport-specific environments.
A case of high-grade non-intestinal paranasal sinus adenocarcinoma primary in the maxillary sinus: targeted therapy after postoperative immunocombination with chemotherapy
Authors: Yang Lu , Lu Lu , Ma Ji , Xu Zaihua , Li Na 
Published: August 2024

Abstract
Background
High-grade non-intestinal-type sinonasal adenocarcinoma (non-ITAC) is a rare and aggressive form of adenocarcinoma with poor prognosis. The current standard treatment approach involves surgery combined with radiation therapy. However, there is a need for exploring additional treatment modalities to improve patient outcomes.

Case presentation
We present a case of a 65-year-old male patient who presented with pain in the right maxillary sinus and was diagnosed with high-grade non-ITAC following surgery. Postoperative pathology revealed tumor invasion into bone tissue and vascular invasion, necessitating further treatment. The patient underwent radiation therapy, followed by immunotherapy with carilizumab combined with chemotherapy. During the maintenance immunotherapy period, tumor progression was observed, and genetic testing identified EGFR and TP53 mutations. Consequently, the patient was treated with gefitinib, a targeted therapy drug. Notably, the patient’s lung metastases showed a gradual reduction in size, indicating a favorable treatment response. The patient is currently undergoing oral treatment with gefitinib.

Conclusions
This case report highlights the potential benefit of combining immunotherapy and targeted therapy in the treatment of high-grade non-ITAC. Despite the rarity of this cancer type, this approach may offer an alternative treatment strategy for patients with this aggressive disease. We hope that this case can contribute to a deeper understanding of high-grade non-ITAC and promote the application of immunotherapy and targeted therapy in improving survival rates for patients with this condition.