bluuebunny/crossref_metadata_2025_split huggingface dataset:
How safe is Celecoxib for Asian–Indian patients with rheumatic diseases?
Authors: Danda Debashish , Iliyas Mohamed M. , Chandy Sujith J. , Chandra Cheemalapati , Mathew Ashish J. 
Published: January 2013

AbstractBackgroundCyclo‐oxygenase (COX)‐2 inhibitors have been the target of severe criticism, more so following the withdrawal of Rofecoxib. Post‐marketing surveillance of Celecoxib in Asian Indians, who are predisposed to premature athero‐thrombotic events, has not been studied.AimsTo study the adverse effects of Celecoxib and compare them with those of other non‐steroidal anti‐inflammatory drugs (NSAIDs) in an Asian Indian cohort.Materials and methodsThis is a retrospective chart review with convenience sampling of patients on NSAIDs (at least five tablets a week, for at least 3 months prior to the study), attending the Rheumatology clinic of a tertiary care institution in south India between June 2004 and November 2004. Those with pre‐existing heart disease, hypertension, thrombo‐embolic disease, peptic ulcer and patients on corticosteroids were excluded. All the recorded adverse events were noted and compared between the Celecoxib and non‐selective NSAID users. Univariate analysis using Chi‐square test was performed.ResultsOf the 1387 patients included, 915 were on Celecoxib. In the NSAID group, 204 had used multiple NSAIDs in sequence. Of the Celecoxib users, 164 had switched over to an NSAID during the study period. New onset of hypertension was significantly higher in the Celecoxib users as compared to non‐selective NSAID users (3.06% vs. 1.27%, P = 0.04). However, those who had switched over to NSAIDs did not show this trend. NSAID users, on the other hand, had significant gastrointestinal (GI) toxicity (2.54% vs. 0.327%, P = 0.001). A significant number of Celecoxib users who switched over to NSAIDs also developed GI toxicity (6.1% vs. 1.21%, P = 0.018) over a shorter time span, as compared to the continuous NSAID users. Multiple NSAID users had higher adverse events (6.37% vs. 2.23%, P = 0.023) as compared to single NSAID users.ConclusionCelecoxib significantly increased the incidence of new onset hypertension in this cohort of Indian patients with rheumatic diseases. No thromboembolic events were documented.
Bleeding complications after central line insertions: relevance of pre‐procedure coagulation tests and institutional transfusion policy
Authors: KANDER T. , FRIGYESI A. , KJELDSEN‐KRAGH J. , KARLSSON H. , ROLANDER F. , SCHÖTT U. 
Published: January 2013

BackgroundThe aim of this study was to map pre‐procedural variables for insertion of a central venous catheter, prophylactic blood component use and to investigate whether any independent variable could be identified as an independent risk factor for associated bleeding complications in patients outside the intensive care unit.MethodsIn this retrospective study, we investigated 1737 consecutive insertions of central venous catheters in 1444 patients in a large university hospital during 2009–2010. Pre‐procedural coagulation status, blood component use, type of catheter, insertion site and complications during insertion were recorded and compared with bleeding complications documented on electronic charts.ResultsNo serious bleeding complications were recorded in connection with the insertion of central venous catheters. Sixteen of 1769 (0.9%) insertions caused grade 2 bleeding, defined as bleeding requiring prolonged compression at the insertion site. Insertion of a large bore central dialysis catheter was found to be an independent risk factor for bleeding complications. Neither conventional coagulation tests nor accidental arterial puncture or the number of needle passes could predict bleeding complications in this study.ConclusionThis retrospective study, in non‐ICU patients, shows that serious bleeding complications in association with central line insertions are uncommon and that insertion of a large bore catheter is likely to be an independent risk factor for mild‐bleeding complications in this population.
Investigating the performance of different estimation techniques for crop yield data analysis in crop insurance applications
Authors: Finger Robert 
Published: January 2013

AbstractWe investigate the performance of the ordinary least squares (OLS)‐, M‐, MM‐, and the Theil–Sen (TS)‐estimator for crop yield data analysis in crop insurance applications using Monte Carlo simulations. More specifically, the performance is assessed with respect to trend estimation, prediction of future yield levels, and the estimation of expected indemnity payments. In agreement with earlier findings, other estimators are found to be superior to OLS in simple regression problems if yield distributions are outlier contaminated and heteroscedastic. While this conclusion is also valid for subsequent applications such as yield prediction and the estimation of expected indemnity payments, the difference between the considered estimators becomes less distinct. For these applications, we find particularly the M‐estimator to be a good compromise between high‐breakdown (very robust) estimators and the very efficient OLS‐estimator. Because no regression technique dominates all others in all applications and scenarios for error term distributions, our results underline that the choice of the estimation technique should be dependent on the purpose of the crop yield data analysis. However, alternative estimators such as M‐, MM‐, and TS‐estimator can reduce (and bound) the risk of unreliable or inefficient crop yield data analysis in crop insurance applications.
Endovascular therapy for penetrating ulcers of the infrarenal aorta
Authors: Georgiadis George S. , Trellopoulos George , Antoniou George A. , Georgakarakos Efstratios I. , Nikolopoulos Evagelos S. , Pelekas Dimitrios , Pitta Xanthi , Lazarides Miltos K. 
Published: January 2013

AbstractBackgroundWe sought to investigate the short‐ and mid‐term results of the endovascular repair of infrarenal abdominal penetrating aortic ulcers (aPAUs).MethodsPatients with infrarenal aPAUs treated by endovascular means between March 2004 and June 2012 were recruited. Pre‐interventional imaging included computed tomography (CT) or CT angiography. Endoprostheses were chosen and deployed according to standard elective endovascular aneurysm repair anatomical requirements. Endpoints included 30‐day survival, in‐hospital mortality, 1‐year PAU‐related mortality, 1‐year all‐cause mortality, freedom from death and freedom from cumulative complication and interventions. Statistically, the Kaplan–Meier method was applied.ResultsNineteen patients (18 men, median age 70 years (interquartile range, IQR = 59–75)) suffering aPAUs (n = 29, infrarenal = 25) were detected. The median co‐morbid severity scoring was 1.0 (IQR = 0.4–1.4). The median follow‐up period was 33 months (IQR = 8–51.5). Furthermore, 94.7% of patients had hypertension. Fourteen patients (73.7%) had symptoms, including four of them admitted with shock from large‐contained PAU rupture. Endoluminal stent grafting was successfully delivered in all patients. In‐hospital mortality was 10.5%. Two patients required secondary interventions (10.5%). The 30‐day survival, 1‐year PAU‐related mortality and 1‐year all‐cause mortality were 94.7%, 89.5% and 89.5%, respectively. Freedom from death and freedom from cumulative complications and interventions was 86.4% and 86.4%, 78.9% and 78.9%, and 67.9% and 71.2% at 12, 24 and 36 months, respectively.ConclusionsUrgent and elective endovascular repair of aPAUs can be achieved with high technical success. The significant co‐morbid status of the treated patients is illustrated in the considerable in‐hospital mortality and underlines the advantage of such treatment over open surgical repair.
The Box–Cox Transformation and Non‐Iterative Estimation Methods for Ordinal Log‐Linear Models
Authors: Beh Eric J. , Farver Thomas B. 
Published: January 2013

SummaryRecently Beh and Farver investigated and evaluated three non‐iterative procedures for estimating the linear‐by‐linear parameter of an ordinal log‐linear model. The study demonstrated that these non‐iterative techniques provide estimates that are, for most types of contingency tables, statistically indistinguishable from estimates from Newton's unidimensional algorithm. Here we show how two of these techniques are related using the Box–Cox transformation. We also show that by using this transformation, accurate non‐iterative estimates are achievable even when a contingency table contains sampling zeros.
Cat admissions toRSPCAshelters in Queensland,Australia: description of cats and risk factors for euthanasia after entry
Authors: Alberthsen C , Rand JS , Bennett PC , Paterson M , Lawrie M , Morton JM 
Published: January 2013

ObjectiveA lack of information limits understanding of the excess cat problem and development of effective management strategies. This study describes cats entering Royal Society for the Prevention of Cruelty to Animals (RSPCA) Queensland shelters and identifies risk factors for euthanasia.MethodsData for cats entering relevant shelters (July 2006–June 2008) were obtained from the RSPCA's electronic database. Univariable and multivariable logistic regression analyses were conducted to identify risk factors for euthanasia.ResultsOf 33,736 cats admitted, 46% were adult cats (≥3 months) and 54% were kittens (<3 months). The most common reason for admission was stray (54%), followed by owner surrender (44%). Euthanasia was the most common outcome (65%), followed by adoption (30%). The odds of euthanasia were lower for kittens and for cats that were desexed prior to admission. Of the strays, 8% had been desexed. For cats of similar age, sex, desexed and feral status, stray cats were more likely to be adopted than owner‐surrenders.ConclusionsStrategies are needed to reduce numbers of cats admitted and euthanased. Given the high proportion of admissions that were kittens, reducing the incidence of delayed sterilisation of owned cats may be an important strategy for reducing the number of unwanted kittens. Many cats admitted as strays were rehomable, but given the high proportion of admissions that are strays, further research on stray populations is needed. Future studies of cats entering shelters would be enhanced if data collection definitions, categories and methods were standardised.
Mothers, places and risk of hospitalization for childhood asthma: a nationwide study from Sweden
Authors: Li X. , Sundquist J. , Calling S. , Zöller B. , Sundquist K. 
Published: January 2013

SummaryObjectiveThis study examines whether neighbourhood deprivation increases the risk of hospitalization for childhood asthma, after accounting for individual‐level maternal socio‐demographic characteristics.DesignAn open cohort of all singleton children aged 2–11 years was followed between January 1, 1995 and December 31, 2006. Childhood residential addresses were geocoded and classified according to the level of neighbourhood deprivation. Data were analysed by multilevel logistic regression, with individual‐level characteristics (sex, age, maternal marital status, family income, maternal educational attainment, maternal immigration status, maternal urban/rural status, mobility, maternal asthma history and maternal smoking) at the first level and level of neighbourhood deprivation at the second level.ResultsDuring the study period, among a total of 866 860 children, 17 682 (2.0%) were hospitalized with childhood asthma. Age‐adjusted hospital rates for childhood asthma increased with increasing level of neighbourhood deprivation. In the study population, 1.9% and 2.3% of children in the least and most deprived neighbourhoods, respectively, were affected by childhood asthma. Hospital rates of childhood asthma increased with increasing neighbourhood‐level deprivation across all individual‐level maternal socio‐demographic categories, including marital status, educational attainment, urban/rural status, maternal history of asthma and smoking. The odds ratio (OR) for those living in high‐deprivation neighbourhoods vs. those living in low‐deprivation neighbourhoods was 1.23 (95% confidence interval, 1.16–1.30). High neighbourhood deprivation remained significantly associated with childhood asthma risk after adjustment for maternal socio‐demographic characteristics (OR=1.08, p = 0.016).ConclusionsThis study is the largest so far on neighbourhood influences on childhood asthma. Our results suggest that neighbourhood characteristics affect the risk of hospitalization for childhood asthma independent of maternal socio‐demographic characteristics.
Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes
Authors: Simon M C , Bilan S , Nowotny B , Dickhaus T , Burkart V , Schloot N C 
Published: January 2013

Summary
Fatty acids, uric acid and glucose are thought to contribute to subclinical inflammation associated with diabetes mellitus. We tested whether co-incubation of free fatty acids and uric acid or glucose influences the secretion of immune mediators from stimulated human whole blood in vitro. Fresh whole blood samples from 20 healthy subjects, 20 patients with type 1 diabetes and 23 patients with type 2 diabetes were incubated for 24 h with palmitic acid (PAL), linolenic acid (LIN) or eicosapentaenoic acid (EPA) alone or together with elevated concentrations of uric acid or glucose. Concentrations of proinflammatory cytokines interleukin (IL)-1β, IL-2, IL-12(p70), IL-18, IFN-γ, of regulatory cytokines IL-4, IL-10, IL-17 and chemokine CCL2 (MCP-1) were measured by multiplex-bead technology from supernatants. Co-incubation of fatty acids with uric acid resulted in a significant reduction of IL-10, IL-12(p70), IFN-γ and CCL2 (MCP-1) concentrations in supernatants compared to incubation with uric acid alone (P &lt; 0·0001). In contrast, IL-18 was up-regulated upon co-stimulation with fatty acids and uric acid. Similarly, co-incubation of fatty acids with glucose diminished secretion of IL-10, IFN-γ and CCL2 (monocyte chemotactic protein-1), while IL-8 was up-regulated (P &lt; 0·001). Samples from healthy and diabetic subjects did not differ after adjustment for age, sex, body mass index and diabetes type. All three fatty acids similarly influenced whole blood cytokine release in vitro and modulated uric acid or glucose-stimulated cytokine secretion. Although the ω-3-fatty acid EPA showed slightly stronger effects, further studies are required to elaborate the differential effects of PAL, LIN and EPA on disease risk observed previously in epidemiological studies.
Cardiac magnetic resonance imaging in Turner syndrome
Authors: Gutmark‐Little Iris , Backeljauw Philippe F. 
Published: January 2013

SummaryGirls and women with Turner syndrome (TS) have a highly increased morbidity as the result of cardiovascular disease, both congenital and acquired. Increased clinical use of cardiac magnetic resonance imaging (CMR) in patients with TS over recent years has allowed for characterization of disease not always possible with standard imaging modalities, such as echocardiography (echo). In this review, we discuss the current literature regarding CMR in patients with TS and guidelines for its use.
Two decades of occupational (meth)acrylate patch test results and focus on isobornyl acrylate
Authors: Christoffers Wietske A. , Coenraads Pieter‐Jan , Schuttelaar Marie‐Louise A. 
Published: January 2013

SummaryBackgroundAcrylates constitute an important cause of occupational contact dermatitis. Isobornyl acrylate sensitization has been reported in only 2 cases. We encountered an industrial process operator with occupational contact dermatitis caused by isobornyl acrylate.Objectives(i) To investigate whether it is relevant to add isobornyl acrylate to the (meth)acrylate test series. (ii) To report patients with (meth)acrylate contact allergy at an occupational dermatology clinic.Patients/materials/methodsOur patch test database was screened for positive reactions to (meth)acrylates between 1993 and 2012. A selected group of 14 patients was tested with an isobornyl acrylate dilution series: 0.3%, 0.1%, 0.033%, and 0.01%. Readings were performed on D2, D3, and D7.ResultsOne hundred and fifty‐one patients were tested with our (meth)acrylate series; 24 had positive reactions. Most positive reactions were to 2‐hydroxypropyl acrylate, 2‐hydroxyethyl acrylate, 2‐hydroxypropyl methacrylate, and diethyleneglycol diacrylate. Hypothetical screening with 2‐hydroxypropyl acrylate, ethyleneglycol dimethacrylate, ethoxylated bisphenol A glycol dimethacrylate and trimethylolpropane triacrylate identified 91.7% of the 24 patients. No positive reactions were observed in 14 acrylate‐positive patients tested with the isobornyl acrylate dilution series. The 0.3% isobornyl acrylate concentration induced irritant reactions in 3 patients.ConclusionsWe report a rare case of allergic contact dermatitis caused by isobornyl acrylate. However, this study provides insufficient support for isobornyl acrylate to be added to a (meth)acrylate series.
Undergraduate degree projects in the Swedish dental schools: a documentary analysis
Authors: Franzén C. , Brown G. 
Published: January 2013

AbstractBackgroundUndergraduate degree projects have currently been introduced into courses in the four Swedish dental schools. The rationale for research projects is that they enable students to develop research expertise skills and to show their ability to apply and develop knowledge relevant to professional practice. This paper reports a qualitative analysis of the curriculum documents and handbooks including the criteria used to assess the students' research reports. The aim was to investigate commonalities and differences in the design of degree projects between the four Swedish dental schools and to explore any inconsistencies within the documents.MethodsThe documentary analysis was based on the constant comparison method.ResultsFour overarching themes emerged from the analysis: (i) developing scientific expertise, (ii) developing professional expertise, (iii) following rules and (iv) fostering creativity.ConclusionsThe documents from the four dental schools revealed similar views on the purposes of the projects and provided similar assessment criteria. The students were requested to formulate an odontological problem, apply a relevant scientific method, analyse texts and empirical data, express critical reflections and write a short thesis. The students were free to choose topics. There were differences between the dental schools on the emphasis placed on practical uses of the projects and theoretical background of the projects. Two of the schools insisted on rigid rules of completing and writing the project yet paradoxically emphasised creativity. There were wide variations in the required length of the project report. The report may prove useful to dental schools in other countries who are about to design undergraduate research projects.
The regenerative potential of fibroblasts in a new diabetes‐induced delayed humanised wound healing model
Authors: Martínez‐Santamaría Lucía , Conti Claudio J. , Llames Sara , García Eva , Retamosa Luisa , Holguín Almudena , Illera Nuria , Duarte Blanca , Camblor Lino , Llaneza José M. , Jorcano José L. , Larcher Fernando , Meana Álvaro , Escámez María J. , Del Río Marcela 
Published: January 2013

AbstractCutaneous diabetic wounds greatly affect the quality of life of patients, causing a substantial economic impact on the healthcare system. The limited clinical success of conventional treatments is mainly attributed to the lack of knowledge of the pathogenic mechanisms related to chronic ulceration. Therefore, management of diabetic ulcers remains a challenging clinical issue. Within this context, reliable animal models that recapitulate situations of impaired wound healing have become essential. In this study, we established a new in vivo humanised model of delayed wound healing in a diabetic context that reproduces the main features of the human disease. Diabetes was induced by multiple low doses of streptozotocin in bioengineered human‐skin‐engrafted immunodeficient mice. The significant delay in wound closure exhibited in diabetic wounds was mainly attributed to alterations in the granulation tissue formation and resolution, involving defects in wound bed maturation, vascularisation, inflammatory response and collagen deposition. In the new model, a cell‐based wound therapy consisting of the application of plasma‐derived fibrin dermal scaffolds containing fibroblasts consistently improved the healing response by triggering granulation tissue maturation and further providing a suitable matrix for migrating keratinocytes during wound re‐epithelialisation. The present preclinical wound healing model was able to shed light on the biological processes responsible for the improvement achieved, and these findings can be extended for designing new therapeutic approaches with clinical relevance.
Abiotic and biotic factors affecting recruitment variability of walleye pollock (Theragra chalcogramma) off thePacific coast ofHokkaido,Japan
Authors: Funamoto Tetsuichiro , Yamamura Orio , Kono Tokihiro , Hamatsu Tomonori , Nishimura Akira 
Published: January 2013

AbstractAbiotic and biotic factors affecting the recruitment variability of the Japanese Pacific stock (JPS) of walleye pollock (Theragra chalcogramma) were examined using a bivariate regression and multivariate combined model. Of the abiotic variables aroundFunkaBay (spawning ground), February sea surface temperature (SST) and wind direction index showed significant bivariate relationships with recruitment. FebruarySSTwas positively related to recruitment, suggesting that warmer water temperature inFebruary favorsJPSrecruitment. On the other hand, the relationship betweenFebruary wind direction index and recruitment predicts highJPSrecruitment under predominant northwest winds in February. For the biotic variables in theDoto area (nursery ground), significant and negative bivariate relationships with recruitment were observed for catch per unit effort ofKamchatka flounder (Atheresthes evermanni),Pacific cod (Gadus macrocephalus), and walleye pollock, implying an important impact of predation by these groundfishes onJPSrecruitment. The overall model incorporating these abiotic and biotic factors successfully reproduced the variability inJPSrecruitment. Temperature and wind conditions around the spawning ground along with predator condition in the nursery ground appear to play a dominant role in the recruitment dynamics ofJPS. Based on these results and prior knowledge, we propose a new hypothesis to explain the processes controllingJPSrecruitment.
Determination of seven preservatives in cosmetic products by micellar electrokinetic chromatography
Authors: Huang Jun‐Qiang , Hu Cho‐Chun , Chiu Tai‐Chia 
Published: January 2013

SynopsisA micellar electrokinetic chromatography method using cetyltrimethylammonium bromide (CTAB) as a cationic surfactant, coupled with UV–Vis detection, was developed for the simultaneous determination of seven preservatives, including methyl‐, ethyl‐, propyl‐ and butyl‐paraben and phenol, phenoxyethanol and resorcinol. The method involved optimizing the pH of the phosphate buffer and concentrations of CTAB, ethanol and 2‐hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD). The preservatives were well separated using optimum conditions and separated within 10 min at a separation voltage of −12.5 kV with the 1.0 mM phosphate buffer (pH 7.0) containing 90 mM CTAB, 25 mM HP‐β‐CD and 10% (v/v) ethanol. Satisfactory recoveries (84.1–103.0%), migration time (RSD < 3.1%) and peak area (RSD < 4.5%) repeatabilities were achieved. Detection limits of the preservatives were between 0.31 and 1.52 μg mL−1 (S/N = 3, n = 5). The optimized method was successfully applied to the simultaneous determination of these preservatives in 10 commercial cosmetic products.