bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tunable 200 GHz lens‐coupled annular‐slot antennas using Schottky varactor diodes for all‐electronic reconfigurable terahertz circuits
Authors: Jiang Z. , Rahman S. M. , Fay P. , Hesler J. L. , Liu L. 
Published: November 2013

A tunable lens‐coupled annular‐slot antenna using a Schottky varactor diode has been designed, fabricated and characterised at 140 to 220 GHz. Simulation results show that the resonant frequency of the annular‐slot antenna can be effectively tuned by varying the capacitance of the imbedded varactor diode, with an average tunability of ∼2.5 GHz/fF. Prototype demonstration using a varactor with zero‐bias capacitance of 3.8 fF has shown a frequency tuning range from 197 to 202.7 GHz by varying the diode DC bias voltage from 1 to −5 V (corresponding to a diode capacitance change from 4.97 to 2.4 fF). The measured tunability is 2.22 GHz/fF, which agrees well with simulation. Projections indicate tuning ranges of ∼50 GHz in the G‐band should be possible using varactor diodes with ∼20 fF zero‐bias capacitance.
Power‐gating technique for network‐on‐chip buffers
Authors: Casu M.R. , Yadav M.K. , Zamboni M. 
Published: November 2013

A new approach to reducing leakage power in network‐on‐chip buffers is presented. The non‐uniformity of buffer utilisation is leveraged across the network and power‐gating is applied to scarcely utilised buffers. Instead of turning‐off the buffers completely, a buffer portion is kept turned‐on. This design choice has a significant performance benefit because the buffer is always able to receive network packets. Design aspects and trade‐offs in a 45 nm CMOS technology are discussed and results obtained over video application benchmarks are presented. It is shown that it is possible to reduce buffer leakage by 40% without performance penalty.
Comparative modelling of differential through‐silicon vias up to 40 GHz
Authors: Lu Kuan‐Chung , Horng Tzyy‐Sheng 
Published: November 2013

The three‐dimensional integrated circuit has attracted considerable attention because of the evolving functions of today's integrated circuit products and a continuing demand for reduced power consumption and miniature chip size. Through‐silicon vias (TSVs) provide a vertical interconnection between stacked dies; they are much shorter and have a denser connectivity than the hybrid horizontal and bondwire interconnects in conventional use. Differential interconnects are more commonly used in high‐speed digital circuits rather than single‐ended ones because of their higher immunity to common‐mode noise. Accordingly, presented is a scalable physical model for differential TSVs. Mixed‐mode S‐parameters were generated using the established model and the electrical performance of a GSSG‐type differential TSV was compared with that of a GSGSG‐type differential TSV. Furthermore, four‐port S‐parameters were measured up to 40 GHz to validate the modelled results.
Interaction of ganglioside GD3 with an EGF receptor sustains the self-renewal ability of mouse neural stem cells in vitro
Authors: Wang Jing , Yu Robert K. 
Published: November 2013

Significance
Gangliosides are abundantly expressed in the nervous system and are known to play important roles in neurodevelopment. We previously demonstrated that GD3 is a predominant ganglioside species (>80% of the total gangliosides) in mouse neural stem cells (NSCs). To investigate its biological function, we found that GD3 is colocalized and interacts with the mitogen receptor EGFR in the microdomain structure of the plasma membrane. Such an interaction preserves the EGFR via an endosomal-plasma membrane recycling pathway after endocytosis of EGF and facilitates the EGF-mediated signaling responsible for regulating NSC cell-fate determination. This is an example of how a specific ganglioside can mediate the reuse of a mitogen receptor for promoting efficient cellular proliferation.
Computational evaluation of cellular metabolic costs successfully predicts genes whose expression is deleterious
Authors: Wagner Allon , Zarecki Raphy , Reshef Leah , Gochev Camelia , Sorek Rotem , Gophna Uri , Ruppin Eytan 
Published: November 2013

Significance
Biologists frequently overexpress genes to learn about their cellular functions, and biotechnologists do so to construct novel metabolic pathways that produce valuable chemical compounds. However, gene overexpression often leads to deleterious consequences whose cause is unclear. Here, we present a computational method named Expression-Dependent Gene Effects (EDGE) that can successfully predict the deleterious effects resulting from overexpression of either native or foreign (originating in another species) metabolic genes. EDGE relies on genome-scale metabolic models, an emerging computational paradigm for studying metabolism in silico. Beyond its biotechnological significance, gene overexpression also plays an important role in human disease. We show EDGE’s applicability in the latter case by demonstrating its ability to detect toxic genes whose expression tends to be suppressed in cancer cells.
Changing hydration level in an internal cavity modulates the proton affinity of a key glutamate in cytochromecoxidase
Authors: Goyal Puja , Lu Jianxun , Yang Shuo , Gunner M. R. , Cui Qiang 
Published: November 2013

SignificanceCytochromecoxidase is an important proton pump that utilizes the chemical energy released by oxygen reduction to generate the transmembrane proton concentration gradient. A conserved glutamate residue has been proposed to play a key role in proton pumping, although factors that control the timing and destination of proton transfers by this residue remain poorly understood. By integrating results from multiple computational methodologies, we propose a mechanism in which changes in local hydration and electrostatic interactions regulate the proton affinity of this key residue and, as a result, proton transfer activities. The results highlight the functional significance of local protein motions and hydration state of internal cavities.
Filopodial retraction force is generated by cortical actin dynamics and controlled by reversible tethering at the tip
Authors: Bornschlögl Thomas , Romero Stéphane , Vestergaard Christian L. , Joanny Jean-François , Van Nhieu Guy Tran , Bassereau Patricia 
Published: November 2013

Significance
Cells can sense their environment by using hair-like structures called filopodia that often exert pulling forces upon adhesive tip contact. We show, using optical tweezers and confocal microscopy, that the retraction force is generated by the dynamics of the cortical actin cytoskeleton, constantly pulling on the filopodial base. The weakest point of force transduction is at the tip between the actin shaft and the membrane. This allows tip-bound filopodia to apply controlled forces and to use a “load-and-fail” sensing process.
Strengthening the Influence of Advertised Reference Prices through Information Priming
Authors: Kan Christina , Lichtenstein Donald R. , Grant Susan Jung , Janiszewski Chris 
Published: November 2013

Abstract
The use of advertised reference price promotions, such as “regularly $119.99, sale price $39.99,” is ubiquitous in the marketplace. Thirty years of research supports the conclusion that advertised reference prices (e.g., $119.99) exert an influence on consumers' responses to offer prices (e.g., $39.99) via their assimilative influence on consumers' internal reference prices. The present research provides an enriched account of this assimilation process. Specifically, three studies show that increasing the overlap in information made accessible by the advertised reference price and information made accessible by the offer price increases the influence of the information primed by the advertised reference price on the construction of the internal reference price. Consequently, the offer price is considered more attractive. The identification of this process provides insight into additional variables that moderate the influence of advertised reference prices on downstream deal evaluations. Implications for theory, practice, and public policy are discussed.
PREDDIMER: a web server for prediction of transmembrane helical dimers
Authors: Polyansky Anton A. , Chugunov Anton O. , Volynsky Pavel E. , Krylov Nikolay A. , Nolde Dmitry E. , Efremov Roman G. 
Published: November 2013

Abstract
Summary: Here we present PREDDIMER, a web tool for prediction of dimer structure of transmembrane (TM) helices. PREDDIMER allows (i) reconstruction of a number of dimer structures for given sequence(s) of TM protein fragments, (ii) ranking and filtering of predicted structures according to respective values of a scoring function, (iii) visualization of predicted 3D dimer structures and (iv) visualization of surface hydrophobicity of TM helices and their contacting (interface) regions represented as 2D maps.
Results: We implemented online the original PREDDIMER algorithm and benchmarked the server on 11 TM sequences, whose 3D dimer conformations were obtained previously by nuclear magnetic resonance spectroscopy. In the most of tested cases backbone root-mean-square deviations of closest predicted conformations from the experimental reference are below 3 Å. A randomization test displays good anticorrelation (−0.82) between values of the scoring function and statistical significance of the prediction ‘by chance’. Going beyond a single dimer conformation, our web tool predicts an ensemble of possible conformations, which may be useful for explanation of a functioning of bitopic membrane proteins, e.g. receptor tyrosine kinases.
Availability and implementation: PREDDIMER can be accessed for free on the web at http://model.nmr.ru/preddimer/
Contact: newant@gmail.com
Supplementary information: Supplementary data are available at Bioinformatics online.
Allelic heterogeneity contributes to variability in ocular dysgenesis, myopathy and brain malformations caused by Col4a1 and Col4a2 mutations
Authors: Kuo Debbie S. , Labelle-Dumais Cassandre , Mao Mao , Jeanne Marion , Kauffman William B. , Allen Jennifer , Favor Jack , Gould Douglas B. 
Published: November 2013

Abstract
Collagen type IV alpha 1 and 2 (COL4A1 and COL4A2) are present in nearly all basement membranes. COL4A1 and COL4A2 mutations are pleiotropic, affecting multiple organ systems to differing degrees, and both genetic-context and environmental factors influence this variable expressivity. Here, we report important phenotypic and molecular differences in an allelic series of Col4a1 and Col4a2 mutant mice that are on a uniform genetic background. We evaluated three organs commonly affected by COL4A1 and COL4A2 mutations and discovered allelic heterogeneity in the penetrance and severity of ocular dysgenesis, myopathy and brain malformations. Similarly, we show allelic heterogeneity in COL4A1 and COL4A2 biosynthesis. While most mutations that we examined caused increased intracellular and decreased extracellular COL4A1 and COL4A2, we identified three mutations with distinct biosynthetic signatures. Reduced temperature or presence of 4-phenylbutyrate ameliorated biosynthetic defects in primary cell lines derived from mutant mice. Together, our data demonstrate the effects and clinical implications of allelic heterogeneity in Col4a1- and Col4a2-related diseases. Understanding allelic differences will be valuable for increasing prognostic accuracy and for the development of therapeutic interventions that consider the nature of the molecular cause in patients with COL4A1 and COL4A2 mutations.
The significant contribution of minor mergers to the cosmic star formation budget
Authors: Kaviraj Sugata 
Published: November 2013

Abstract
We estimate an empirical lower limit for the fraction of cosmic star formation that is triggered by minor mergers in the local Universe. Splitting the star formation budget by galaxy morphology, we find that early-type galaxies (ETGs) host ∼14 per cent of the budget, while Sb/Sc galaxies host the bulk (∼53 per cent) of the local star formation activity. Recent work indicates that star formation in nearby ETGs is driven by minor mergers, implying that at least ∼14 per cent of local star formation is triggered by this process. A more accurate estimate can be derived by noting that an infalling satellite likely induces a larger starburst in a galaxy of ‘later’ morphological type, both due to higher availability of gas in the accreting galaxy and also because a bigger bulge better stabilizes the disc against star formation. This enables us to use the star formation in ETGs to estimate a lower limit for the fraction of star formation in late-type galaxies (LTGs) that is minor-merger-driven. Using a subsample of ETGs that is mass- and environment-matched to the LTGs (implying a similar infalling satellite population), we estimate this limit to be ∼24 per cent. Thus, a lower limit for the fraction of cosmic star formation that is induced by minor mergers is ∼35 per cent [14 per cent (ETGs) + 0.24 × 86 per cent (LTGs)]. The observed positive correlation between black hole and galaxy mass further implies that a similar fraction of black hole accretion may also be triggered by minor mergers. Detailed studies of minor-merger remnants are therefore essential, to quantify the role of this important process in driving stellar mass and black hole growth in the local Universe.
Effects of Rice Flour Blends on Bread Texture and Staling
Authors: Sasaki Tomoko , Kohyama Kaoru , Miyashita Kanae , Okunishi Tomoya 
Published: November 2013

ABSTRACTThe effects of blending rice flour with wheat flour on bread texture and staling were investigated with three rice varieties with different amylose contents. For the texture analysis of bread crumb, the compression test, puncture test, and tensile test were performed. A flour blend containing rice flour suppressed the recovery of the crumb after compression. For the puncture test, blends with rice flour increased the distance to penetrate the crumb. The rupture strain measured with the puncture test decreased with staling of the bread crumb for all samples tested. The fresh bread crumb sample containing waxy rice flour had much greater extensibility in the tensile test than the other samples tested, but it was dramatically decreased after one day of storage. Endothermic enthalpies corresponding to retrograded amylopectin, which is part of the staling process, were also measured. The enthalpy of bread crumb from the blended flour was lower than that of wheat flour bread up to three days but was higher on day 4. A blend of rice flour thus reduced amylopectin retrogradation during early storage, but it was accelerated later. Bread blended with waxy rice flour showed the lowest enthalpy during storage.
Coexpressing Escherichia coli Cyclopropane Synthase with Sterculia foetida Lysophosphatidic Acid Acyltransferase Enhances Cyclopropane Fatty Acid Accumulation
Authors: Yu Xiao-Hong , Prakash Richa Rawat , Sweet Marie , Shanklin John 
Published: November 2013

Abstract
Cyclopropane fatty acids (CPAs) are desirable as renewable chemical feedstocks for the production of paints, plastics, and lubricants. Toward our goal of creating a CPA-accumulating crop, we expressed nine higher plant cyclopropane synthase (CPS) enzymes in the seeds of fad2fae1 Arabidopsis (Arabidopsis thaliana) and observed accumulation of less than 1% CPA. Surprisingly, expression of the Escherichia coli CPS gene resulted in the accumulation of up to 9.1% CPA in the seed. Coexpression of a Sterculia foetida lysophosphatidic acid acyltransferase (SfLPAT) increases CPA accumulation up to 35% in individual T1 seeds. However, seeds with more than 9% CPA exhibit wrinkled seed morphology and reduced size and oil accumulation. Seeds with more than 11% CPA exhibit strongly decreased seed germination and establishment, and no seeds with CPA more than 15% germinated. That previous reports suggest that plant CPS prefers the stereospecific numbering (sn)-1 position whereas E. coli CPS acts on sn-2 of phospholipids prompted us to investigate the preferred positions of CPS on phosphatidylcholine (PC) and triacylglycerol. Unexpectedly, in planta, E. coli CPS acts primarily on the sn-1 position of PC; coexpression of SfLPAT results in the incorporation of CPA at the sn-2 position of lysophosphatidic acid. This enables a cycle that enriches CPA at both sn-1 and sn-2 positions of PC and results in increased accumulation of CPA. These data provide proof of principle that CPA can accumulate to high levels in transgenic seeds and sets the stage for the identification of factors that will facilitate the movement of CPA from PC into triacylglycerol to produce viable seeds with additional CPA accumulation.
An exploratory investigation into the role of a research and development programme on future craft practice
Authors: Valentine Louise , Fillis Ian , Follett Georgina 
Published: November 2013

Purpose
– The purpose of this paper is to assess the effectiveness of a research and development programme on improving craft practice through the provision of mentoring by academic practitioners, studio space and advice on marketing techniques.

Design/methodology/approach
– Following an initial focus group investigation of issues which impinge on contemporary craft practice, recipients of a bursary associated with the research and development programme were assessed with respect to how their craft and marketing competencies have developed.

Findings
– Practitioners can now reflect on their skills, experiment with techniques and consider the effectiveness of their approach and attitude towards marketing.

Research limitations/implications
– The programme only extends to practitioners working with one art and design institution but has implications for those concerned with creative practice elsewhere.

Practical implications
– There is wider potential to reinvigorate artistic and marketing practice across the creative and cultural industries, and the small and medium enterprise community in general.

Originality/value
– This is a novel programme which challenges experienced practitioners to extend their creative abilities in craft and approaches to marketing.
Happily ever after?
Authors: Münderlein Maria , F. Ybema Jan , Koster Ferry 
Published: November 2013

Purpose
– This paper aims to provide an empirical test of theories proposed in the literature stating that turnover and retirement (two kinds of work withdrawal) involve different employee decisions. It also aims to provide a more general theoretical framework understanding turnover and retirement intentions integrating insights from different theories.

Design/methodology/approach
– Research hypotheses are tested using the Study on Transitions in Employment, Ability and Motivation (STREAM). This dataset includes information from approximately 15,000 respondents in The Netherlands. Respondents between the age of 45 and 64 were the target group in order to model transitions in the labor market for older workers. This dataset provides a unique opportunity to test turnover and retirement intentions.

Findings
– First, the results show that personal characteristics such as income, age or health, add more to the explanation of retirement intentions compared to turnover intentions and that work characteristics provide a better explanation of the turnover intention compared to retirement intention. Second, by focusing more closely on retirement intentions, the results show that organizational motivators can increase older workers' labor market participation.

Research limitations/implications
– First, it is acknowledged that the study investigates intentions rather than actual behavior. Second, given that the data are cross sectional, we cannot make claims about causality. Finally, some of the measures can be improved in future studies.

Originality/value
– This paper aims at integrating different perspectives on two kinds of work withdrawal (turnover and retirement) into one theoretical model.
Price regulation and cost accounting: the case of the Portuguese seaport sector
Authors: Martins António , Jorge Susana , Sá Patrícia 
Published: November 2013

Purpose
– The purpose of this paper is to illustrate how a stakeholder approach based on a case-study research was used to define a method to be applied across the Portuguese seaport administrations (SA) in order to justify the tariffs to be charged for a variety of services provided by these entities.

Design/methodology/approach
– The study involved both the Portuguese maritime transport regulator (IPTM) and the SA in the various stages that led to the proposition of a new method to be applied in cost calculation and reporting. Acting as consultant-researchers, the authors have used a multiplicity of data sources (e.g. regulations, reports and interviews), while involving users and providers of information in the design of the proposed method.

Findings
– The common acceptance of a set of rules regarding minimum levels of harmonisation in computing tariffs based on cost coverage was possible thanks to a strategy that has fostered a collaborative and interactive process engaging consultants and clients. The defined method respects the main principles and good practices of cost accounting, namely those related to cost traceability, classification and controllability. Moreover, it specifies how certain elements (e.g. depreciation, external services and personnel charges) with impact on cost structures of seaports should be measured according to the new financial accounting standards. The technical solution proposed represents a good compromise, while cost accounting systems in Portuguese SA are still under development.

Originality/value
– The paper describes the application of a case-study methodology to the resolution of a problem where requirements of customisation and harmonisation were essential to enhance the quality of the solution, as perceived by both the regulator and SA.
Export market location decision and performance
Authors: He Xinming , Wei Yingqi 
Published: November 2013

Purpose– Drawing on the resource-based view and network theory, the purpose of this paper is to investigate the role of external networks (ENs) and absorptive capacity (AC) in export market location decision of emerging economy firms (EEFs) and the performance implication of this decision.Design/methodology/approach– This study employs structural equation modeling to test three hypotheses: first, ENs influence an EEF manager's propensity to enter culturally/psychically distant markets for exports. Distant markets are more likely to be chosen by managers of firms with abundant ENs. Second, AC moderates this network-market location relationship. Third, superior performance results from the fit between managers’ propensity to enter a market and firms’ levels of ENs and AC.Findings– An analysis of 196 Chinese exporting firms supports the hypotheses.Research limitations/implications– Though the theoretical discussion is general, the empirical context is specific to Chinese export manufacturers. Replicating the study is necessary in different contexts.Practical implications– The study identifies to managers the importance of external (i.e. ENs) and internal resources and capabilities (i.e. AC) and linkages between resources and capabilities, strategy and performance.Originality/value– The study is novel in conceptually addressing the role of ENs and AC in firms’ decision making and performance and in testing hypotheses with robust methodology and data.