bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blast Exposure Associations With Hearing Loss and Self‐Reported Hearing Difficulty
Authors: McIntire Aaron , Miller Tanner , Thapa Samrita , Joseph Antony , Carlson Kathleen F. , Reavis Kelly M. , Hughes Charlotte K. 
Published: July 2024

AbstractObjectiveExamine associations between military blast exposures on hearing loss and self‐reported hearing difficulties among Active‐Duty Service Members (ADSM) and Veterans from the Noise Outcomes in Servicemembers Epidemiology (NOISE) study.Study DesignCross‐sectional.SettingMulti‐institutional tertiary referral centers.MethodsBlast exposure was assessed with a comprehensive blast questionnaire. Outcome measures included pure‐tone hearing thresholds; Speech Recognition in Noise Test; Hearing Handicap Inventory for Adults (HHIA); and Speech, Spatial and Qualities of Hearing Scale (SSQ)‐12.ResultsTwenty‐one percent (102/494) of ADSM and 36.8% (196/533) of Veterans self‐reported blast exposure. Compared to ADSM without blast exposure, blast‐exposed ADSM had increased odds of high frequency (3‐8 kHz) and extended‐high frequency (9‐16 kHz) hearing loss (odds ratio [OR] = 2.5, CI: 1.3, 4.7; OR = 3.7, CI: 1.9, 7.0, respectively). ADSM and Veterans with blast exposure were more likely than their nonblast exposed counterparts to report hearing difficulty on the HHIA (OR = 1.9, CI: 1.1, 3.3; OR = 2.1, CI: 1.4, 3.2, respectively). Those with self‐reported blast exposure also had lower SSQ‐12 scores (ADSM mean difference = −0.6, CI: −1.0, −0.1; Veteran mean difference: −0.9, CI: −1.3, −0.5).ConclusionResults suggest that blast exposure is a prevalent source of hearing injury in the military. We found that among ADSM, blast exposure was associated with hearing loss, predominately in the higher frequencies. Blast exposure was associated with poorer self‐perceived hearing ability in ADSM and Veterans.IRB#FWH20180143H Joint Base San Antonio (JBSA) Military Healthcare System; #3159/9495 Joint VA Portland Health Care System (VAPORHCS) Oregon Health and Science University (OHSU).
Improving interface performance between the fibers and rubber using metal cations synergistic polydopamine to modify carbon fibers
Authors: Zhao Meng , Chen Haiming , Zhang Lin , Dong Juyuan , Han Linfeng , Wang Haitong , Yang Weimin , Lin Guangyi 
Published: July 2024

AbstractCF‐PDA‐M hybrid fillers are prepared by three metal cations (M) assisting polydopamine (PDA) through Fe3+, Ni2+, and Al3+. The metal cations promote the polymerization of PDA on the fiber surface, shorten the modification time of the fibers, and ensure that the short‐cut carbon fibers (CF) do not agglomerate during water bath stirring while keeping the structure of the CF undamaged, which is a green and efficient method. After PDA modification, the roughness and surface activity of the fiber surface increase. Finally, CF‐PDA‐M is used as a filler and added to neoprene latex and natural latex, which are prepared into composites by wet blending, and the CF are characterized by different techniques. The results show that the hydroxyl and amino groups on the surface of CF‐PDA‐M increase the cross‐linking density of the composites, establish a good stress cross‐linking network, shorten the vulcanization time, effectively prevent the agglomeration phenomenon of the CF in the rubber, and improve the dispersion of the CF in the composite. After modification, the tensile strength and 300% constant tensile strength of CF‐PDA‐M increase by more than 10% and 30%, respectively, over CF composites, and the rolling resistance is reduced. This study provides a new and effective strategy for CF surface functionalization, which improves the processing efficiency and mechanical properties of rubber products and has a broad application prospect in the rubber industry.
A comparative study on the anti‐bacterial properties of three types of silver nano packaging based on (PLA, TiO2, PE) on Husinae Acipenseridae (Huso huso)
Authors: Salimi Fatemeh , Ahari Hamed , Anvar Seyed AmirAli , Motallebi Moghanjoghi Abbasali 
Published: July 2024

AbstractNanoparticles (NPs) in a variety of types are used in food packaging films. Ag NPs and Ag@TiO2 NPs were embedded in polyethylene (PE) and polylactic acid (PLA) based films in an effort to create unique films that would effectively extend the shelf life of beluga sturgeon fish. To achieve this, 22 films were formulated. Two of them were nominated based on an antibacterial evaluation. Pure PE and PLA were selected as control groups. TEM, SEM, FTIR, EDX, AFM, and tensile strength were employed to study the films chemically, physically, and mechanically. The films were used to package beluga sturgeon fish for 6 days, and then humidity, TVN, PV, and colony count were measured. According to the results, Ag@TiO2 NPs had higher antibacterial activity than AgNPs. Films with 3% of Ag@TiO2 NPs showed higher microorganism growth inhibition. The addition of Ag@TiO2 NPs increased the mechanical properties. Both selected films, controlled humidity (<70%), TVN (20 mg/100 g fish), and PV (<6 meq gr O2/kg fat) after 6 days. It was also confirmed that Ag@TiO2 NPs showed notable antibacterial activity after 6 days. The best results belonged to PE + 3% Ag@TiO2 film. To sum up, PE + 3% Ag@TiO2 film can be a good candidate for marine food packaging.Highlights
Ag and Ag@TiO2 nanoparticles were studied on polyethylene and polylactic acid.
This packaging reveals the favorable effect of Ag@TiO2.
This packaging prolongs fish's shelf life under refrigeration.
Ag@TiO2 increased both mechanical strength and barrier properties.
Analysis of three primary prostatic sarcoma cases and literature review
Authors: Wei Yirui , Wang Hao , Xie Dawei , Lu Jun , Liang Xiaolong , He Weifeng , Yang Pushen , Wang Jianwen 
Published: July 2024

AbstractObjectiveThe objective of this study is to evaluate the clinical presentations, diagnostic approaches, and treatment modalities for primary prostate sarcoma postradical prostatectomy, aiming to enhance its diagnosis and management.MethodsWe retrospectively reviewed the clinical records of three male patients diagnosed with primary prostate sarcoma at Beijing Chaoyang Hospital, affiliated with Capital Medical University, from February 2014 to February 2024. All patients underwent transrectal prostate biopsies, which informed the decision to proceed with laparoscopic radical prostatectomies. After surgery, one patient received a combination of epirubicin and ifosfamide as immunotherapy, along with external beam radiotherapy. After comprehensive discussions regarding potential benefits and risks, the remaining two patients decided against undergoing radiotherapy and chemotherapy.ResultsBased on the pathological examination results, two patients were diagnosed with stromal sarcoma and one with spindle cell sarcoma, all classified as high‐grade sarcomas. Immunohistochemical analysis showed that all three cases were positive for VIMENTIN, but other results did not show significant specificity. During the follow‐up period, one patient died within 12 months, and two patients were lost to follow‐up after 6 months. However, there were no evident signs of recurrence observed during the follow‐up period.ConclusionsPrimary prostate sarcoma is extremely rare and typically has a poor prognosis once diagnosed. Early diagnosis should be based on pathological and immunohistochemical testing results, followed by prompt surgical treatment and adjuvant radiotherapy and chemotherapy. Despite these measures, recurrence is common, underscoring the need for a detailed and appropriate treatment plan and systematic therapy for affected patients.
HcGr76 responds to fructose and chlorogenic acid and is involved in regulation of peptide expression in the midgut of Hyphantria cunea larvae
Authors: Sun Jing , Zhang Wenjing , Cui Zhebo , Pan Yifan , Smagghe Guy , Zhang Longwa , Wickham Jacob D. , Sun Jianghua , Mang Dingze 
Published: July 2024

AbstractBACKGROUNDSensing dietary components in the gut is important to ensure an appropriate hormonal response and metabolic regulation after food intake. The fall webworm, Hyphantria cunea, is a major invasive pest in China and has led to significant economic losses and ecosystem disruption. The larvae's broad host range and voracious appetite for leaves make H. cunea a primary cause of serious damage to both forests and crops. To date, however, the gustatory receptors (Grs) of H. cunea and their regulatory function remain largely unknown.RESULTSWe identified the fall webworm gustatory receptor HcGr76 as a fructose and chlorogenic acid receptor using Ca2+ imaging and determination of intracellular Ca2+ concentration by a microplate reader. Moreover, reverse transcription–quantitative polymerase chain reaction (RT–qPCR) analysis revealed that HcGr76 is highly expressed in the anterior and middle midgut. Knockdown of HcGr76 caused a significant reduction in the expression of neuropeptide F 1 (NPF1) and CCHamide‐2, and led to a decrease in carbohydrate and lipid levels in the hemolymph.CONCLUSIONOur studies provide circumstantial evidence that HcGr76 expressed in the midgut is involved in sensing dietary components, and regulates the expression of relevant peptide hormones to alter metabolism in H. cunea larvae, thus providing a promising molecular target for the development of new insect‐specific control products. © 2024 Society of Chemical Industry.
Exploring Stratification Strategies for Population‐ Versus Randomization‐Based Inference
Authors: Novelli Marco , Rosenberger William F. 
Published: July 2024

ABSTRACTStratification on important variables is a common practice in clinical trials, since ensuring cosmetic balance on known baseline covariates is often deemed to be a crucial requirement for the credibility of the experimental results. However, the actual benefits of stratification are still debated in the literature. Other authors have shown that it does not improve efficiency in large samples and improves it only negligibly in smaller samples. This paper investigates different subgroup analysis strategies, with a particular focus on the potential benefits in terms of inferential precision of prestratification versus both poststratification and post hoc regression adjustment. For each of these approaches, the pros and cons of population‐based versus randomization‐based inference are discussed. The effects of the presence of a treatment‐by‐covariate interaction and the variability in the patient responses are also taken into account. Our results show that, in general, prestratifying does not provide substantial benefit. On the contrary, it may be deleterious, in particular for randomization‐based procedures in the presence of a chronological bias. Even when there is treatment‐by‐covariate interaction, prestratification may backfire by considerably reducing the inferential precision.
Improved high‐performance liquid chromatography tandem mass spectrometry method for quantification of infliximab in pediatric plasma and its application in therapeutic drug monitoring
Authors: Yu Boran , Jin Siyao , Han Jiaqi , Li Xiaona , Xu Jiamin , Sun Ning , Sun Liang , Wang Xiaoling , Zhao Libo 
Published: July 2024

AbstractRationaleThe application of infliximab (IFX) to immune‐mediated disease is limited by the significant individual variability and associated clinical nonresponse, emphasizing the importance of therapeutic drug monitoring (TDM). Because of the cross‐reactivity, limited linear range, and high costs, the clinical application of the previous reported methods was limited. Here, an improved high‐performance liquid chromatography tandem mass spectrometry (HPLC‐MS/MS) method was developed to address the issues.MethodsThis study developed an improved bioanalytical HPLC‐MS/MS method coupling nanosurface and molecular‐orientation limited proteolysis technology. The commercially available compound P14R was selected as the internal standard. This method was developed with fewer volume of reagents and was thoroughly validated. The validated method was applied to TDM in pediatric inflammatory bowel disease (IBD).ResultsChromatography was performed using a Shim‐pack GISS‐HP C18 metal‐free column (3 μm, 2.1 × 100 mm) with a gradient elution of 0.1% formic acid in water and acetonitrile at 0.4 mL/min. Detection and quantitation were performed using electrospray ionization (ESI) and multiple reaction monitoring in the positive ion mode. The method was validated to demonstrate its selectivity, linearity, accuracy, precision, recovery, matrix effect, and stability. The method exhibited a linear dynamic range of 0.3–100 μg/mL, with intra‐ and inter‐day precision and relative errors below 15%. The recovery and matrix effect were measured as 87.28%–89.72% and 41.98%–67.17%, respectively, which were effectively compensated by the internal standard. A total of 32 samples collected from 24 pediatric patients with IBD were analyzed using the validated method, and only 46.9% achieved the reported targeted trough level.ConclusionThis study developed an improved HPLC‐MS/MS method for the quantitative determination of IFX concentration in human plasma. The accurate, reliable, and cost‐effective method was validated and utilized in the analysis of clinical samples. The results confirmed the importance of TDM on IFX and the clinical application prospects of the improved method.
Development of allergic bronchopulmonary aspergillosis in a patient with nontuberculous mycobacterial‐pulmonary disease successfully treated with dupilumab: A case report and literature review
Authors: Onozato Ryuta , Miyata Jun , Asakura Takanori , Namkoong Ho , Asano Koichiro , Hasegawa Naoki , Fukunaga Koichi 
Published: July 2024

AbstractPulmonary manifestations in patients with allergic bronchopulmonary aspergillosis (ABPA) and nontuberculous mycobacterial‐pulmonary disease (NTM‐PD) include bronchiectasis and mucus plugging. A 68‐year‐old woman, treated with antibiotics and inhaled corticosteroids for NTM‐PD and asthma, presented with fever and wheezing. ABPA was diagnosed based on laboratory findings (elevated peripheral blood eosinophil counts and serum total IgE levels and positive Aspergillus‐specific IgE and IgG) and imaging observation of a high‐attenuation mucus plug. Systemic prednisolone was avoided to prevent NTM‐PD progression. Dupilumab, a monoclonal antibody that blocks IL‐4/13, was introduced to improve the clinical findings. Herein, we discuss the pathophysiological mechanisms underlying this rare comorbidity.
Event‐triggered output quantization control for asynchronously switched interval type‐2 fuzzy systems
Authors: Yang Yachun , Li Xiaodi , Liu Xinzhi 
Published: July 2024

AbstractThis article considers exponential stabilization (ES) of switched interval type‐2 (SIT2) fuzzy systems with asynchronous switching control. The SIT2 fuzzy system switches from one mode to another according to transition probabilities (TPs). A general SIT2 fuzzy quantized event‐triggered output controller (QETOC) is designed to save the communication resources. The QETOC employs distinctive membership functions from those of the IT2 fuzzy model and switches with mode‐pendent switching delay, which is more practical than asynchronously switched control techniques with a common switching delay and control schemes without TP. By designing discretized multiple Lyapunov function (DMLF) and using convex combination technique, sufficient conditions formulated by linear matrix inequalities (LMIs) are obtained to ensure that the DMLF does not ‘jump high’ at the moment of switching, and hence the conservatism of obtained results is significantly reduced since no additional dwell time is needed for the stabilization. It is discovered that the SIT2 fuzzy system is not necessary to be unstable on mismatched intervals, and it can be unstable on matched intervals. The advantages of theoretical analysis are verified by numerical simulations, and the classical assumption that each subsystem is unstable on mismatched intervals is conservative for control design.
Impact of technological advancement and greener energy on sustainable agriculture in Asia: Evidence from selected Asian countries
Authors: Sharma Gagan Deep , Shah Muhammad Ibrahim , Chopra Ritika , Rao Amar , Shahzad Umer 
Published: July 2024

AbstractRegardless of major advancements in food production, Asia continues to confront severe food security challenges. Sustainable agriculture presents entirely new prospects by prioritizing the productive worth of human, social, and natural capital—all of which are abundant in Asian nations or can be replenished at a relatively low financial expense. This paper sets out to explore the role of technological innovation, renewable energy use, financial development, globalization, and institutional quality on the environmental sustainability of agriculture, measured by the greenhouse gas emissions from the agricultural sector for top 10 agricultural economies of Asia from 1990 to 2019. To attain the above objective, we employ a variety of econometric models capable of accounting for cross‐sectional dependence, including the CS‐ARDL model and the Dumitrescu‐Hurlin Panel Granger Causality tests. The result indicates that technological innovation as well as the use of renewable energy can reduce the greenhouse gas emissions from the agricultural sector and thus contribute towards enhancing environmental performance of this sector in short and long run. Although globalization result is revealed to be positive, it turns out to be insignificant in both short and long run. Financial development exerts positive and significant effects on agricultural emissions while the institutional quality is found to be increasing the agricultural environmental performance. Finally, we provide policy recommendations based on the results of the study.
Fabrication of Biomimetic Hydrophobic Surfaces Using Phyto‐Polymers and their Bimetallic Au@Ag Nanoparticles
Authors: Krishnan Sundarrajan Sasireka , Pottail Lalitha 
Published: July 2024

AbstractGreen phyto technology is a novel version, and the intersection of nanotechnology with nanobiotechnology gains much attention among global researchers owing to the vast range of industrial, environmental and medical applications. To synthesize bimetallic nano particles of Au@Ag, corresponding metal precursors were added to aqueous fruit latex extract of Artocarpus heterophyllus (AHL) & bark latex extract of Mimusops elengi (MEM) and exposed to sunlight. Hydrophobic surfaces are often designed to mimic low surface energy materials and hierarchical micro/nanostructures. In this study, hydrophobic surfaces on glass substrates were fabricated using a simple immersion process that was rapid, facile, and environmental friendly. Latex extracts, Au@Ag nanoparticles, stearic acid and methyltrichlorosilane were used in the coatings. The shape, heterogeneity, roughness and surface functionality of modified hydrophobic surfaces were investigated by FESEM, 3D profilometer and FT‐IR studies. The contact angle (CA) of modified surfaces was measured by Goniometer. The anti‐corrosive property of modified hydrophobic surfaces was tested. Recent micro/nanotechnological advancements have inspired artificial changes of surface wettability by bio‐mimic surfaces with efficient nanoparticles.
Substituent Effect on Physical Properties of Whitening Lignin
Authors: Shikinaka Kazuhiro , Suzuki Asami , Otsuka Yuichiro 
Published: July 2024

AbstractIn this paper, the substituent effect on physical properties of whitening lignin prepared by solvent‐controlled encapsulation (SCE) was estimated. Firstly, it was revealed that lignin whitening via SCE requires the modification of alkyl isocyanate containing the alkyl chain with more than four carbon atoms. This indicates the importance of the bulkiness of the substituent of isocyanate moiety for the realization of SCE, i. e., lignin whitening. Secondly, the thermal stability of whitened lignin is dramatically improved by the replacement of the mono‐isocyanate moiety with diisocyanate moiety. Thirdly, the whitened lignin modified by m‐xylylene‐diisocyanate exhibited high thermal stability and electrical insulating properties, suggesting its possible application to insulating fillers for poly(ϵ‐caprolactone).
Exploring of Dual Effect of Light And Ultrasound On Effective Singlet Oxgyen Generation of Newly Synthesized Mg(II), Zn(II) And In(III)Cl Phthalocyanines as Sono‐Photochemically
Authors: Kiliçarslan Fatma Aytan , Kocaağa Nagihan , Erdoğmuş Ali 
Published: July 2024

AbstractEvery year, cancer claims the lives of hundreds of thousands of people, despite the fast advancements in science and technology. Numerous scientific investigations are conducted to create therapeutic approaches that do not have the drawbacks of conventional cancer treatment methods. A novel approach to treating cancer is sono‐photodynamic therapy, which has a far higher therapeutic efficacy than photodynamic therapy. For this purpose, peripherally bis 3‐[(4‐tert‐butylbenzyl)oxy substituted metal and metal‐free phthalocyanines were synthesized and characterized. Additionally, the spectral, aggregation and sonophotochemical properties of these phthalocyanines in DMSO were examined. Metallophthalocyanines to generate singlet oxygen was examined photochemically and sonophotochemically. The findings of the sono‐photochemical experiments showed great promise, showing that the synthesized sensitizers were effective at producing reactive oxygen species for successful therapeutic treatments. The development of innovative therapeutic medicines with improved photodynamic and sonodynamic characteristics is aided by this discovery. Using sonophotodynamic therapy to concurrently harness the power of light and sound is a novel and synergistic technique that may enhance the therapeutic efficacy of these complexes. For the investigated al of compounds, The combination of sonochemical and photochemical applications generated better results. Overall, the findings point to SPDT as a potentially effective combination therapy for the treatment of cancer.
Synthesis and Characterization of Nanocellulose/Polyacrylonitrile‐based Carbon Nanofibers: An Approach toward Low Cost and Sustainable Agro Waste based Carbon Nanomaterials
Authors: Suman  , Rani Sonu , Bajaj Bharat 
Published: July 2024

AbstractThe cost of polymer precursors and high energy need in carbonization for the preparation of carbon materials are two limiting factors in the commercialization of carbon‐based materials. In this study, carbon nanofiber films were prepared by adding a very small concentration of polymer polyacrylonitrile in nanocellulose (extracted from agro waste i.e., rice straws) with an overall aim of producing carbon nanomaterials with cost effective, renewable and sustainable carbon source. Polyacrylonitrile (PAN) added nanocellulose solution was drop‐casted to prepare Nanocellulose/Polyacrylonitrile‐based nanofibers film (NC/PAN). It was further stabilized in air atmosphere at 280 °C followed by carbonized in nitrogen atmosphere at 700 °C. It was found that addition of NC/PAN have 18 % lower activation energies than PAN. Results of tunneling electron microscopy showed that polyacrylonitrile/nanocellulose films carbonized at 700 °C temperature exhibited amorphous carbon nanofibers structure similar to bare polyacrylonitrile based carbon film carbonized at higher temperature of 1000 °C‐1200 °C. Furthermore, polyacrylonitrile/nanocellulose based carbon nanofibers have showed high degree of carbonization ((ID)/(IG)=0.87) as compared to bare polyacrylonitrile based carbon nanofibers film ((ID)/(IG)=1.02). This may be attributed to chiral nature of nanocellulose which served as a template to orientation of graphene planes and showed efficient carbonization.