bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinically significant changes in anal sphincter hiatal area in patients with gestational diabetes mellitus and pelvic organ prolapse
Authors: Wang Qing-Hong , Liu Li-Hua , Ying Hua , Chen Ming-Xu , Zhou Chang-Jiang , Li Hui 
Published: July 2024

BACKGROUND
The prevalence of pelvic organ prolapse (POP) increases with age and parity. Specifically, the prevalence of POP among women aged 20 to 39 is 9.7%, while it rises to 49% among women over 80 years old. Additionally, as the number of deliveries increases, the prevalence of POP also rises accordingly, with a rate of 12.8% for women with one delivery history, 18.7% for those with two deliveries, and 24.6% for women with three or more deliveries. It causes immense suffering for pregnant women.
AIM
To evaluate the relationship between the levator ani muscle’s hiatus (LH) area and POP in patients with gestational diabetes mellitus (GDM) using perineal ultra-sound.
METHODS
The study cohort comprised 104 patients aged 29.8 ± 3.7 years who sought medical care at our institution between January 2021 and June 2023. All were singleton pregnancies consisting of 75 primiparas and 29 multiparas, with an average parity of 1.7 ± 0.5. According to the POP diagnostic criteria, the 104 subjects were divided into two groups with 52 members each: POP group (patients with GDM combined with POP) and non-POP group (patients with GDM without POP). Perineal ultrasound was used to measure differences in the anteroposterior diameter, transverse diameter, and LH area. Receiver operating characteristic curves were drawn to determine the optimal cutoff values for the LH anteroposterior diameter, transverse diameter, and area for diagnosing POP.
RESULTS
Statistically significant increase in the LH area, anteroposterior diameter, and lateral diameter were observed in the POP group compared with the non-POP group (P < 0.05). Both groups exhibited markedly elevated incidence rates of macrosomia and stress urinary incontinence. For the POP group, the area under the curve (AUC) for the LH area was 0.906 with a 95% confidence interval (CI): 0.824-0.988. The optimal cutoff was 13.54cm², demonstrating a sensitivity of 83.2% and a specificity of 64.4%. The AUC for the anteroposterior diameter reached 0.836 with a 95%CI: 0.729-0.943. The optimal cutoff was 5.53 cm with a sensitivity of 64.2% and a specificity of 73.4%. For the lateral diameter, its AUC was 0.568 with a 95%CI: 0.407-0.729. The optimal cutoff was 4.67 cm, displaying a sensitivity of 65.9% and a specificity of 69.3%. Logistic regression analysis unveiled that age, body weight, number of childbirths, total number of pregnancies, and gestational weight gain constituted the independent risk factors for the cooccurrence of GDM and POP.
CONCLUSION
Three-dimensional perineal ultrasonography of LH size and shape changes can effectively diagnose POP. Age, weight, number of births, number of pregnancies, and weight gain during pregnancy are independent risk factors affecting the cooccurrence of GDM and POP. GDM can increase the LH area in patients, and an enlarged LH leads to an increased incidence of POP.
Mitigating diabetes-related complications: Empowering metformin with cholecalciferol and taurine supplementation in type 2 diabetic rats
Authors: Attia Mai S , Ayman Fadwa , Attia Mohamed S , Yahya Galal , Zahra Mansour H , Khalil Magdi Mohamed Ibrahim , Diab Abdel Aziz A 
Published: July 2024

BACKGROUND
Type 2 diabetes is one of the most prevalent chronic diseases worldwide, significantly impacting patients' quality of life. Current treatment options like metformin (MET) effectively counteract hyperglycemia but fail to alleviate diabetes-associated complications such as retinopathy, neuropathy, nephropathy, hepatopathy, and cardiovascular diseases.
AIM
To propose the supplementation of cholecalciferol (CHO) and taurine (TAU) to enhance MET efficacy in controlling diabetes while minimizing the risk of associated complications.
METHODS
The study involved sixty rats, including ten non-diabetic control rats and fifty experimental rats with type 2 diabetes induced by streptozotocin. The experimental rats were further subdivided into positive control and treatment subgroups. The four treatment groups were randomly allocated to a single MET treatment or MET combined with supplements either CHO, TAU, or both.
RESULTS
Diabetic rats exhibited elevated levels of glucose, insulin, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), glycated hemoglobin%, lipid markers, aspartate aminotransferase, and malondialdehyde, along with reduced levels of antioxidant enzymes (catalase and superoxide dismutase). The administration of CHO and TAU supplements alongside MET in diabetic rats led to a noticeable recovery of islet mass. The antioxidative, anti-inflammatory, and anti-apoptotic properties of the proposed combination therapy significantly ameliorated the aforementioned abnormalities.
CONCLUSION
The supplementation of CHO and TAU with MET showed the potential to significantly improve metabolic parameters and protect against diabetic complications through its antioxidative, anti-inflammatory, and anti-apoptotic effects.
A Clinical Audit of Post-Operative Outcomes of Laparoscopic Nissen’s Fundoplication in a Single Center in Sub-Saharan Africa
Authors: Munguti Cecilia Muvenyi , Ndung'u Bernard 
Published: July 2024

Introduction: Gastroesophageal reflux disease (GERD) is a common benign condition with a population prevalence of 18–28%. Laparoscopic antireflux surgery is increasingly being offered to patients with GERD in our setting; however, the outcomes remain unknown.
Methodology: A retrospective clinical audit of patients who underwent laparoscopic Nissen’s fundoplication in a single center. Data were summarized as mean (±SD) and median (interquartile range [IQR]); associations were analyzed with Chi square or Fischer’s exact test. A Modified Visick scoring system was used to assess the severity of symptoms after surgery. Regression models were used to analyze the factors associated with recurrence. Kaplan–Meier plots were plotted, and cox regression models, hazard ratio, and their confidence intervals were calculated.
Results: A total of 127 patients were identified, with 6 having had previous laparoscopic Nissen’s fundoplication. Post-operative modified Visick scores at 2 weeks and 3 months were 1.04 (±0.05) and 1.03 (±0.04), respectively, for both typical and atypical symptoms. The recurrence rate was 12.6%, with 87.4% 5-year recurrence-free survival.
Conclusion: Laparoscopic Nissen’s fundoplication provides good control of both typical and atypical GERD symptoms with a low recurrence rate and a 5- year recurrence-free survival that is comparable to universal rates.
Variations in the Branching of the Coronary Artery among Black African Population: A cadaveric study in western Kenya
Authors: Olgah Otieno Anyango , Domnic Marera Oduor , Gideon Ngwâ€™ena Magak 
Published: July 2024

Introduction: The right and the left coronary arteries are the principal branches of the coronary artery. These blood vessels are responsible for the overall blood supply to the muscles of the heart. Variations are anomalies in the branching pattern of the coronary arteries which can affect the amount of blood reaching the myocardium. This can lead to technical problems during procedures like cardiac catheterization causing misdiagnosis resulting in complications during diagnostic intervention in surgical procedures of the heart. This study sought to determine these variations among the black African population in Western Kenya by assessing the variations in the branching pattern of the coronary arteries.
Materials And Methods: A cross-sectional study design was used in the Maseno University, Uzima University and Masinde Muliro University Human anatomy laboratories which were selected through purposive sampling. Branches of the coronary artery was the dependent variable while gender was the independent variable. Seventy-two (72) sample size was calculated using Cochran's formula. Data sheets were used to capture the variables while descriptive statistics was used to calculate the frequency and percentage of variation in the branching of the coronary arteries. Pearson’s correlation test was used to analyze the relationship between the variables and variations with a P=≤ 0.05 considered as significant. Ethical approval was put into consideration and a license number: NACOSTI /P/22/21905 was issued.
Results: The posterior descending artery had the most variations on the left coronary at 20.8% artery while on the right the sinoatrial nodal artery varied most with 2.8% originating from the right aortic cusps while the remaining originating from the posterior descending artery.
Conclusions And Recommendations: Variations were most on the left coronary artery which could jeopardize surgeries leading to misdiagnosis and fatalities. Increased awareness among the population with early routine imaging is key in managing variations is needed.
MAMA Decoction, Nigerian Herbal Antimalarial Preparation, Alters the Disposition of Amodiaquine in Healthy Humans
Authors: Adepiti A.O. , Adehin A. , Ogunlade O. , Asafa M.A. , Adeagbo B.A. , Bolaji O.O. , Elujoba A.A. 
Published: July 2024

Background: MAMA Decoction (MD) is prepared from the leaves of Mangifera indica, Alstonia boonei, Morinda lucida and Azadirachta indica. A co-administration of MD with amodiaquine led to synergism in the clearance of malaria parasites in a previous report. The pharmacokinetic basis for this observation was the subject of another study in mice which found significant MD- induced increase in the exposure and half-life of desethylamodiaquine, the major metabolite of amodiaquine.Objective: This study aimed at evaluating previously identified murine herb-drug interactions in healthy human volunteers.Materials and Methods: Single oral doses of amodiaquine (10 mg/kg) with/without MD (120 mg/kg) were coadministered to 16 healthy subjects in a three-period crossover design. Five millilitres of blood samples were collected employing sparse sampling from 0.25, 0.5, 1, 2, 4, 8, 12, 24 and 48 h postdose, for each study period and analysed for amodiaquine and desethylamodiaquine contents. The effect of MD on amodiaquine disposition across study periods was investigated using a non-linear mixed-effect pharmacokinetic model which estimated population parameters with the stochastic approximation expectation maximization algorithm implemented in Monolix 2020R1.Results: The disposition of amodiaquine and desethylamodiaquine was each described, adequately, by two- and onecompartment structural models respectively, and a first-order oral absorption rate. The co-administration of amodiaquine with MD resulted in about 41% decrease in the apparent volume of distribution of amodiaquine (VAQ/F). Pre-administration of MD prior to amodiaquine led to a 22% decrease in VAQ/F.Conclusion: MAMA decoction appeared to decrease the tissue partitioning of amodiaquine in man. The consequence of this on effective parasite clearance in man is, not yet understood.
<i>In Silico</i> Identification of Canthin-6-one as a Pancreatic Lipase Inhibitory Anti-Obesity Drug Lead from <i>Hibiscus Sabdariffa</i>
Authors: Ajala O.S. , Okechukwu P.U. , Innocent-Ugwu D.O. , Dada O.H. 
Published: July 2024

Background: The therapeutic use of the only Pancreatic Lipase (PL) - inhibiting anti-obesity drug available in clinical practice, orlistat, is bedevilled with unbearable side effects, necessitating the discovery of new and better-tolerated ones. Hibiscus sabdariffa, a folkloric anti- obesity plant is a plausible repertoire from which such agents could be sought.
Objective: The main objective of this work was to evaluate in silico the phytochemicals of Hibiscus sabdariffa for a possible identification of potential leads for PL inhibitory anti-obesity drug discovery.
Methods: Phytoligands from H. sabdariffa were subjected to a series of in silico evaluations including site directed docking, MM/GBSA calculations, SwissADME drug-likeness screening, Protox II-based toxicity evaluations and a 20 ns molecular dynamics (MD) simulation.
Results: MM/GBSA ranking of docked phytoligands and SwissADME evaluations produced three PL inhibitor hits. One of them, canthin-6-one, demonstrated minimal end-organ toxicity with a 1200 mg/kg LD50; its PL complex generated stability-implying root mean square deviation (RMSD), root mean square fluctuation (RMSF), radius of gyration (Rg) and solvent accessible surface area (SASA) plots, after the 20 ns MD simulation.
Conclusion: Hibiscus sabdariffa-based canthin-6-one has demonstrated, in silico, high human PL binding affinity, impressive drug-likeness/toxicity profiles and stability-implying MD simulation parameters. It is therefore, herein, recommended as lead for further in vitro, in vivo and molecular modification studies for possible development into a clinical PL inhibitory anti-obesity drug.
Algunas ideas después de la reforma de “Vos estis lux mundi”
Authors: Bernal José 
Published: July 2024

El papa Francisco promulgó la Carta Apostólica en forma motu proprio “Vos estis lux mundi” (=VELM) con la finalidad de prevenir y combatir los delitos de abuso sexual. Desde la entrada en vigor el i de junio de 2019 de VELM han visto la luz varia reformas normativas de bastante calado, que afectaban al contenido del VELM de 2019. Después el Papa francisco promulgó una nueva versión en marzo de 2023. El presente trabajo afronta algunos puntos de VELM que deberían ser reformados o expresados de forma más clara.
Pengaruh Motivasi Belanja Hedonis dan Utilitarian Terhadap Konsumsi Berkelanjutan Tenun Endek Pewarnaan Alam
Authors: Dwinata JS I Putu Wahyu , Julianti Pambudi Yustikarani , Pradnyan Permana Usadi Made , Yuninata Dama 
Published: July 2024

Endek merupakan salah satu tenun tradisional khas Bali yang saat ini sudah mulai berkembang dalam proses produksinya salah satunya tenun endek ramah lingkungan dengan proses pewarnaan alami dan menjadi salah satu pilihan bagi konsumen yang berminat pada konsumsi berkelanjutan. Penelitian ini mengadopsi teori motivasi belanja yaitu motivasi utilitarian dan hedonis dengan tujuan untuk menguji pengaruh motivasi belanja konsumen terhadap niat pembelian produk ramah lingkungan tenun endek pewarnaan alam. Sebanyak 190 responden menjadi sampel dalam penelitian kuantitaif dengan metode purposive sampling. Pengolahan data menggunakan aplikasi Smart-PLS menghasilkan bahwa kenyamanan, ketersediaan informasi, seleksi, dan penawaran yang disesuaikan, berpengaruh positf terhadap motivasi utilitarian. Selain itu tren, sosial, dan pertualangan berpengaruh positif terhadap motuvasi hedonis, namun otoritas dan status tidak memiliki pengaruh yang signifikan pada motivasi hedonis. Penelitian ini juga mengungkapkan bahwa motivasi utilitarian berpengaruh secara positif terhadap minat pembelian hijau, sedangkan motivasi hedonis tidak memiliki pengaruh yang signifikan terhadap minat pembelian hijau.
Analisis Manajemen Kearsipan Dalam Upaya Meningkatkan Pengelolaan Penatausahaan Administrasi Di Dinas Perumahan Dan Kawasan Permukiman Kota Gunungsitoli
Authors: Waruwu Wulan Arini , Mendrofa Martha Surya Dinata , Waruwu Eliyunus , Gea Jeliswan Berkat Iman Jaya 
Published: July 2024

Penelitian ini bertujuan untuk menganalisis manajemen kearsipan dalam upaya meningkatkan pengelolaan penatausahaan administrasi dan mengetahui kendala manajemen kearsipan dalam upaya meningkatkan pengelolaan penatausahaan administrasi di Dinas Perumahan dan Kawasan Permukiman kota Gunungsitoli. Jenis penelitian yang digunakan dalam penelitian ini adalah penelitian deskriptif, dengan pendekatan kualitatif. Metode pengumpulan data yang digunakan antara lain observasi, wawancara, dan dokumentasi. Teknik analisis data yang digunakan dalam penelitian ini adalah reduksi data, penyajian data dan menarik kesimpulan/ verifikasi. Hasil penelitian menunjukkan bahwa pengelolaan arsip pada Dinas Perkim Kota Gunungsitoli belum terlaksana secara optimal, masih banyaknya masalah-masalah yang terjadi dalam proses pengelolaan arsip mulai dari penciptaan hingga pemusnahan arsip, hal tersebut membuat proses dari pengelolaan tersebut belum optimal. Dalam pelaksanaan pengelolaan arsip Dinas Perkim Kota Gunungsitoli menghadapi beberapa hambatan yaitu kurangnya pengetahuan pegawai, kurangnya sarana dan prasarana yang memadai, ketiadaan gedung khusus tempat penyimpanan arsip, belum melaksanakan penyusustan dokumen arsip, tidak ada SOP penyimpanan arsip, serta tantangan penggunaan arsip digital.

Kata kunci: Manajemen Kearsipan, Pengelolaan Penatausahaan Administrasi.
Penerapan Sistem Informasi Akuntansi Penjualan Pada CV Kirana Cahaya Sejahtera
Authors: Telaumbanua Rahmaddin , Kakisina Sophia Molinda , Zebua Fakta Solala , Zebua Dedi Irawan 
Published: July 2024

Abstrak: Tujuan penelitian ini adalah merancang Sistem Informasi Akuntansi (SIA) Penjualan pada Entitas Mikro Kecil dan Menengah khususnya pada CV Kirana Cahaya Sejahtera yang bergerak pada bidang perdagangan eceran barang dan obat farmasi untuk manusia di apotek. Perancangan Sistem Informasi Akuntansi Penjualan untuk CV Kirana Cahaya Sejahtera dilaksanakan menggunakan metode (1) Perancangan struktur organisasi yang bisa membagi peran tugas beserta kewenangan dengan jelas, (2) Perancangan Aliran Sistem Informasi (ASI) baru, (3) Perancangan Prosedur sistem akuntansi penjualan, (4) Perancangan Data Flow Diagram, (5) Perancangan Flowchart, (6) Perancangan formulir. Penelitian ini memanfaatkan data kualitatif dengan pendekatan deskriptif dalam menganalisis sistem informasi akuntansi penjualan di CV Kirana Cahaya Sejahtera. Melalui pembuatan sistem informasi yang direncanakan oleh peneliti, diharapkan dapat membantu kinerja perusahaan untuk meningkatkan efisiensi dalam manajemen penjualan obat-obatan dan pengiriman laporan menjadi lebih optimal.

Kata kunci: Sistem Informasi Akuntansi, Flowchart, Prosedur
Penerapan E-Marketing Dan Keunggulan Kompetitif Dalam Meningkatkan Penjualan Produk Pada CV. Bintang Keramik Kota Gunungsitoli
Authors: Bate'e Setiaman , Zalukhu Yuterlin , Laia Otanius , Mendrofa Yupiter 
Published: July 2024

Penelitian ini merupakan penelitian kualitatif deskriptif, yang bertujuan untuk mengetahui bagaimana penerapan e-marketing dan Keunggulan kompetitif yang dilakukan pada CV. Bintang Keramik Kota Gunungsitoli. Adapun data dan informasi yang disampaikan pada penelitian ini didapatkan dari hasil wawancara yang dilakukan oleh peneliti kepada informan. Berdasarkan hasil penelitian yang dilakukan oleh peneliti di CV. Bintang Keramik dapat diketahui bahwa penerapan e-marketing yang dilakukan belum dilaksanakan secara maksimal, hal ini dapat diketahui melalui sarana pemasaran yang digunakan masih sangat terbatas dan tidak dilakukan secara efektif. Selanjutnya upaya dalam meningkatkan keunggulan kompetitif yang dilakukan juga masih belum cukup efesien dimana upaya yang dilakukan belum mampu untuk mendominasi persaingan pasar.

Kata Kunci: Penerapan E-Marketing & Keunggulan Kompetitif dalam Meningkatkan Penjualan
Analisis Prosedur Penghapusan Aset Tetap Pada Dinas Koperasi UKM dan Perdagangan Kabupaten Badung
Authors: Junitasari Putu Diah Krisna , Sari Desak Made Indah Paramitha , Dewi Ni Dewa Ayu Ketut Purnama 
Published: July 2024

Abstrak: Manajemen aset tetap pada sektor publik bahkan harus benar-benar diperhatikan karena akan menimbulkan banyak kecurigaan masyarakat jika pelaporan terhadap pengelolaan aset tetap pada sebuah sektor publik tidak dapat dipertanggugjawabkan, termasuk dalam hal penghapusan aset tetap.
Latar belakang: Adanya pedoman yang seharusnya sektor pemerintahan menggunakan dan menerapkan aturan tersebut dalam proses penghapusan aset tetap. Namun dalam realisasinya terkadang ada aturan-aturan yang tidak digunakan dan diterapkan.
Metode: Dalam penulisan laporan ini penulis melakukan wawancara secara langsung dengan pihak kepengurusan barang yang ada pada sekretariat Dinas Koperasi, UKM, dan Perdagangan Kabupaten Badung serta beberapa pihak yang terkait untuk menggali informasi
Hasil: Pada Dinas Koperasi, UKM dan Perdagangan Kabupaten Badung barang dapat di golongkan menjadi 2 yaitu barang intrakompatabel dan barang ekstrakompatabel, barang intrakompatabel pada Dinas Koperasi, UKM dan Perdagangan Kabupaten Badung meliputi barang-barang yang masuk pada neraca dan harga satuan barang tersebut melebihi Rp.500.000 ribu, sedangkan barang ekstrakompatabel merupakan barang yang tidak tercantum pada neraca dan harga satuan dari barang tersebut tidak lebih dari Rp.500.000 ribu. Adapun total nilai barang intrakompatabel pada Dinas Koperasi, UKM dan Perdagangan Kabupaten Badung yaitu, Rp. 6.911.938.492 dan barang ekstrakompatabel senilai Rp. 86.625.979.
Kesimpulan: Analisis Prosedur Penghapusan Aset Tetap Pada Dinas Koperasi, UKM, dan Perdagangan Kabupaten Badung dapat disimpulkan bahwa prosedur penghapusan aset tetap pada Dinas Koperasi, UKM dan Perdagangan Kabupaten Badung dilakukan dengan tiga cara yaitu lelang, pemindahtanganan dan pemusnahan. Adapun prosedur yang dilakukan untuk dapat melakukan penghapusan aset tetap pada Dinas Koperasi, UKM dan Perdagangan Kabupaten Badung yaitu membuat usulan penghapusan, pengecekan barang, dan yang terakhir penghapusan sesuai dengan hasil pengecekan barang dilelang, dipindahtangankan atau dimusnahkan.
CREACIÓN DE HERRAMIENTA EN LÍNEA, ÚTIL PARA ABORDAR UN PROBLEMA DE VALORES EN LA FRONTERA DEL TIPO DIRICHLET
Authors: Villarreal G. Ramiro A. 
Published: July 2024

Se programó una herramienta digital para utilizarse en línea y gratuita, a través de la plataforma Geogebra. Dicha herramienta resuelve numéricamente la ecuación de Laplace con valores en la frontera (del tipo Dirichlet) para una malla rectangular de 6×6, en la que 20 valores están en la frontera y 25 valores están en el interior, todos distribuidos de manera uniforme en coordenadas cartesianas. El método numérico utilizado para resolver la ecuación diferencial fue el método de diferencias finitas, en el cual se apreció que, para calcular cada valor del campo escalar “ui,j” dentro de la malla rectangular, se realizó el promedio de los valores adyacente al valor en cuestión, es decir

Por otro lado, para plantear el grado de aproximación entre el modelo analítico “MA” (la ecuación de Laplace) y el modelo numérico “MD” (método de diferencias finitas) se realizó una expansión en serie de Taylor, hasta el quinto término, de un valor arbitrario “u(x,y)” del campo escalar, con lo que dicho planteamiento llega al siguiente resultado

En donde el término “TD” es denominado “término de discrepancia”, ya que el mismo marcó la diferencia cuantitativa entre dichos modelos matemáticos. Su forma analítica obtenida fue la siguiente

El término “h” representó la forma en que había sido seccionado la malla. Adicional a esto, si el campo escalar variaba de manera suave y las condiciones en la frontera eran homogéneas, se podía obtener una solución general para la ecuación diferencial de Laplace. En dicha solución, se generaron constantes que dependían de las condiciones de frontera, con lo que se desveló, para un sistema físico estable en concreto, la dependencia del TD con el cuadrado de h.

Resaltó a la vista, el hecho de que al hacer el término h más pequeño, este término de discrepancia se volvió irrelevante y consecuentemente, ambos modelos, analíticos y numérico, mostraron su aproximación.

Para resolver el sistema lineal de ecuaciones de primer grado, se utilizó la regla de Cramer. Para la creación del algoritmo se utilizó el software Geogebra Clásico, Versión 6.0.801.0, el cual es gratuito. El link para acceder a esta herramienta digital es la dirección web, https://www.geogebra.org/m/rmwrxxsa. El objetivo de la creación de esta herramienta estuvo basado en el estudio de sistemas físicos bajo condiciones de equilibrio o estables, tales como: el flujo térmico estable sobre una lámina conductora, una distribución estática de potencial eléctrico sobre una superficie, una distribución de presión que describe el flujo estable de un fluido, etc.