bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting the Optimal Basal Insulin Infusion Pattern in Children and Adolescents on Insulin Pumps
Authors: Holterhus Paul-Martin , Bokelmann Jessica , Riepe Felix , Heidtmann Bettina , Wagner Verena , Rami-Merhar Birgit , Kapellen Thomas , Raile Klemens , Quester Wulf , Holl Reinhard W. ,   the German/Austrian DPV-Initiative and the German Pediatric CSII Working Group
Published: February 2013

OBJECTIVE
We aimed at developing and cross-validating a mathematical prediction model for an optimal basal insulin infusion pattern for children with type 1 diabetes on continuous subcutaneous insulin infusion therapy (CSII).

RESEARCH DESIGN AND METHODS
We used the German/Austrian DPV-Wiss database for quality control and scientific surveys in pediatric diabetology and retrieved all CSII patients &lt;20 years of age (November 2009). A total of 1,248 individuals from our previous study were excluded (dataset 1), resulting in 6,063 CSII patients (dataset 2) (mean age 10.6 ± 4.3 years). Only the most recent basal insulin infusion rates (BRs) were considered. BR patterns were identified and corresponding patients sorted by unsupervised clustering. Logistic regression analysis was applied to calculate the probabilities for each BR pattern. Equations were based on both independent datasets separately, and probabilities for BR patterns were cross-validated using typical test patients.

RESULTS
Of the 6,063 children, 5,903 clustered in one of four major circadian BR patterns, confirming our previous study. The oldest age-group (mean age 12.8 years) was represented by 2,490 patients (42.18%) with a biphasic dawn-dusk pattern (BC). A broad single insulin maximum at 9–10 p.m. (F) was unveiled by 853 patients (14.45%) (mean age 6.3 years). Logistic regression analysis revealed that age, to a lesser extent duration of diabetes, and partly sex predicted BR patterns. Cross-validation revealed almost identical probabilities for BR patterns BC and F in the two datasets but some variation in the remaining two BR patterns.

CONCLUSIONS
Reconfirmation of four key BR patterns in two very large independent cohorts supports that these patterns are realistic approximations of the circadian distribution of insulin needs in children with type 1 diabetes. Prediction of an optimal pattern a priori can improve initiation and clinical follow-up of CSII in children and adolescents. In addition, these BR patterns represent valuable information for insulin-infusion algorithms in closed-loop CSII.
Stability of Finite-difference Schemes for Semilinear Multidimensional Parabolic Equations
Authors: Jovanovic Bosko , Lapinska-Chrzczonowicz Magdalena , Matus Aleh , Matus Piotr 
Published: February 2013

Abstract Abstract — We have studied the stability of finite-difference schemes approximating
initial-boundary value problem (IBVP) for multidimensional parabolic equations with
a nonlinear source of a power type. We have obtained simple sufficient input data
conditions, in which the solutions of differential and difference problems are globally
bounded for all t. It is shown that if these conditions are not satisfied, then
the solution can blow-up (go to infinity) in finite time. The lower bound of the blow-up
time has been determined. The stability of the difference solution has been proven. In
all cases, we used the method of energy inequalities based on the application of the
Chaplygin comparison theorem for nonlinear ODEs, Bihari-type inequalities and their
discrete analogs.
Efficient Halley-like Methods for the Inclusion of Multiple Zeros of Polynomials
Authors: Petković Miodrag S. , Milošević Mimica R. 
Published: February 2013

AbstractStarting from suitable zero-relation, we derive higher-order iterative methods
for the simultaneous inclusion of polynomial multiple zeros in circular complex
interval arithmetic. The convergence rate is increased using a family of two-point
methods of the fourth order for solving nonlinear equations as a predictor. The methods
are more efficient compared to existing inclusion methods for multiple zeros, based
on fixed point relations. Using the concept of the R-order of convergence of mutually
dependent sequences, we present the convergence analysis of the total-step and the
single-step methods. The proposed self-validated methods possess a great computational
efficiency since the acceleration of the convergence rate from four to seven is
achieved only by a few additional calculations. To demonstrate convergence behavior
of the presented methods, two numerical examples are given.
Norms of Discrete Trace Functions of (Ω) and (Ω)
Authors: Xu Jinchao , Zhang Shuo 
Published: February 2013

AbstractThis paper discusses the constructive and computational presentations of several non-local norms of discrete trace functions
of H¹(Ω) and H²(Ω) defined on the boundary or interface of an unstructured grid. We transform the nonlocal norms
of trace functions to local norms of certain functions defined on the whole domain by constructing isomorphic extension operators.
A unified approach is used to explore several typical examples. Additionally, we also discuss exactly invertible Poincaré–Steklov
operators and their discretization.
Domain Decomposition Preconditioning for Problems with Highly Varying Coefficients
Authors: Matsokin Aleksandr , Nepomnyaschikh Sergei 
Published: February 2013

AbstractIn this paper we construct efficient domain decomposition methods for solving
scalar second-order elliptic boundary problems in bounded two-dimensional domains
with small holes, and present some results of numerical experiments, confirming the efficiency
and robustness of the proposed
domain decomposition methods.
An overview of some recent developments on the Invariant Subspace Problem
Authors: Chalendar Isabelle , Partington Jonathan R. 
Published: February 2013

An overview of some recent developments on the Invariant Subspace Problem
This paper presents an account of some recent approaches to the Invariant Subspace Problem. It contains a brief historical account of the problem, and some more detailed discussions of specific topics, namely, universal operators, the Bishop operators, and Read’s Banach space counter-example involving a finitely strictly singular operator.
Aiming point trajectory as an assessment parameter of shooting performance
Authors: Zanevskyy Ihor , Korostylova Yuliya , Mykhaylov Volodymyr 
Published: February 2013

PurposeThe purpose of this study was to elaborate on the scientific methodology for providing an assessment of air-pistol shooters’ aiming stability by (i) substantiating the parameters of aiming stability, (ii) specifying the quantitative evaluation methods in using an optoelectronic target, (iii) evaluating the reliability of tests determining aiming stability, and (iv) developing a methodology for creating individual and group parameters of aiming stability.MethodsThe aiming trajectories of 95 airpistol shooters, each of whom fired 60 shots using a SCATT optoelectronic simulator, were calculated to develop individual and group aiming stability parameters. Research methods included an optoelectronic registration of movement, research on top air-pistol shooters’ sports results, mathematical modelling, variation statistics, cluster analysis, two-way ANOVA with data correlation and reliability theory tests.ResultsIt was found that an average aiming point trajectory on the SCATT optoelectronic target measured one second before a shot could be accepted as an assessment parameter of aiming stability, as it is one of the basic parameters of technical preparation and its position is not influenced by the ballistic characteristics of the pistol and pellets (ŋ = 0.944).ConclusionsThe parameters of aiming stability in air-pistol shooting were developed using a modification of the clustering method. This allows for the identification of weak points in the structure and organization of shooters’ training and for adjustment of the training process.
Advisability on the shift from standard front crawl swimming technique to the “kayaking” and “loping” variants
Authors: Zatoń Krystyna , Szczepan Stefan , Kazimirów Robert , Rejman Marek 
Published: February 2013

PurposeThe aim of this study was to analyze selected kinematics parameters of standard front crawl swimming technique and its variants, the “kayaking” and “loping”, in order to estimate the differences that can determine swimming effectiveness and efficiency.MethodsEighteen swimmers, divided equally into three groups, took part in the research. The first group was composed of individuals who favored the standard technique, the second group used the “kayaking” variant and the third one swam in the “loping” variant. All swimmers were instructed to swim the 50 m freestyle with their technique of choice at maximum velocity. Analysis of kinematic parameters (time, average swimming velocity), swimming cycle parameters (stroke length, stroke rate), and the swimming efficiency coefficient (stroke index) was calculated using SIMI’s 2D Reality Motion Systems software.ResultsThe Kruskal-Wallis test and Mann-Whitney U test found statistically significant differences in the studied parameters between the standard technique (S) and the “kayaking” (K) and “loping” (L) variants in the time to swim 25 m (x̅<sub>S</sub> = 15.472 s, x̅<sub>K</sub> = 13.540 s, x̅<sub>L</sub> = 14.108 s), and between (S) and (K) in the 15 m swim time (x̅<sub>St</sub> = 9.598 s, x̅<sub>Kt</sub> = 8.593 s) and average swimming velocity (x̅<sub>Sv</sub> = 1.562 m/s, x̅<sub>Kv</sub> = 1.757 m/s).ConclusionsAnalysis of the differences in the kinematic parameters that define front crawl swimming technique finds justification in the need to modify the standard technique of the propulsive movement used in swimming towards those that employ the “kayaking” and “loping” variants as they are more effective in affecting swimming velocity.
Effect of thimerosal, methylmercury, and mercuric chloride in Jurkat T Cell Line
Authors: Guzzi Gianpaolo , Pigatto Paolo D. , Spadari Francesco , La Porta Caterina A.M. 
Published: February 2013

ABSTRACT
Mercury is a ubiquitous environmental toxicant that causes a wide range of adverse health effects in humans. Three forms of mercury exist: elemental, inorganic and organic. Each of them has its own profile of toxicity. The aim of the present study was to determine the effect of thimerosal, a topical antiseptic and preservative in vaccines routinely given to children, methyl mercury, and mercuric chloride on cellular viability measured by MTT in Jurkat T cells, a human T leukemia cell line. The treatment of Jurkat T cells with thimerosal caused a significant decrease in cellular viability at 1 μM (25%, p<0.05; IC50: 10 μM). Methyl mercury exhibited a significant decrease in cellular viability at 50 μM (33%, p<0.01; IC50: 65 μM). Mercuric chloride (HgCl2) did not show any significant change in cellular survival. Our findings showed that contrary to thimerosal and methyl mercury, mercuric chloride did not modify Jurkat T cell viability.
Sedimentology and diagenesis as ‘hydrocarbon exploration tools’ in the Late Permian Zechstein-2 Carbonate Member (NE Netherlands)
Authors: Reijers T.J.A. 
Published: February 2013

Abstract
Hydrocarbon exploration in The Netherlands has a chequered history from serendipitous oil shows via chance oil/ gas discoveries to finding the largest continental European oil field in 1943, followed by finding the largest gas field in the world in 1959. The present contribution traces the development of moderate to good porosity/permeability trends in depositional facies of Zechstein Stassfurt carbonates in a ‘gas play’ intermediate in significance between the above two plays but all in the northern part of The Netherlands. Various depositional facies in the Stassfurt carbonates were turned into ‘carbonate fabric units’ by diagenetic processes creating or occluding the porosity/permeability. This formed moderate to good gas reservoirs in barrier-shoal, open-marine shelf and proximal-slope carbonates in the subsurface of the province of Drenthe in the NE Netherlands. The diagenetic models forming these carbonate fabric units are linked to the variety of facies in a depositional model which shows explain and predicts the reservoir trends. Such depositional/diagenetic facies are ‘translated’ into characteristic petrophysical values recognisable on wire line logs in uncored wells, and in characteristic seismic expressions that show these trends in undrilled areas. This approach has been proven to be effective in delineating porosity trends, visualised by 3-D seismic in the Collendoornerveen field, and thus provides a new exploration ‘tool’ in hydrocarbon exploration .
Slide origin of breccia lenses in the Cambrian of the North China Platform: new insight into mass transport in an epeiric sea
Authors: van Loon A.J. (Tom) , Han Zuozhen , Han Yu 
Published: February 2013

Abstract
An oolite in the Furongian (Late Cambrian) Chaomidian Formation in Shandong Province, China, which was deposited on the North China Platform in an epeiric sea, contains several limestone breccia lenses of various dimensions (centimetres to decimetres thick and decimetres to more than 10 metres in length) in an E-trending section. The oolite, which is approximately 40 cm thick, was originally thicker, as indicated by a planar truncation surface that formed by wave abrasion. The breccia lenses in this oolite are generally mound-shaped with a flat base and a convex top. The western margin of the lenses is commonly rounded whereas the eastern margin commonly has a tail (consisting of a rapidly eastwards thinning breccia horizon that gradually ends in a horizon of isolated clasts). Some of the breccia lenses are underlain by a shear zone.
The formation of the breccia lenses cannot be easily explained by normal depositional or deformational processes. It is concluded that the lenses represent fragments of a partly consolidated layer, consisting of both rounded and angular platy clasts, which slid down over a very gently inclined sedimentary surface which acted – possibly together with a water film – as a lubricant layer. During transport, the layer broke up into several discrete bodies that formed small ‘highs’ at the sedimentary surface of the shallow epeiric sea. Subsequently, waves partially eroded the lenses, mostly at their margins, producing their mound-shaped form.
Sliding of blocks is known from a wide variety of environments in the sedimentary record; however, this is the first description of the sliding of blocks in an epeiric sea. This indicates that such a low-relief submarine carbonate setting is, like its siliciclastic counterparts, susceptible to this process.
Antioxidant and Antiradical Properties of Esculin, and its Effect in A Model of Epirubicin-Induced Bone Marrow Toxicity
Authors: Biljali Sefedin , Hadjimitova Vera A. , Topashka-Ancheva Margarita N. , Momekova Denitsa B. , Traykov Trayko T. , Karaivanova Margarita H. 
Published: February 2013

ABSTRACT
AIM: To evaluate the effect of esculin, a plant coumarin glucoside, on free radicals andagainst epirubicin-induced toxicity on bone marrow cells.

MATERIALS AND METHODS: Antioxidant activity was assessed by a luminol-dependent chemiluminescence
method or NBT test in a xanthine-xanthine oxidase system, and two irondependent
lipid peroxidation systems. In vivo experiments were carried out in epirubicintreated
mice, alone or in a combination with esculin. Genotoxicity of the anthracycline
drug was assessed by cytogenetic analysis and an autoradiographic assay.

RESULTS: Esculin inactivated superoxide anion radicals in both systems we used. It exerted
SOD-mimetic effect and reduced the level of superoxide radicals generated in a xanthinexanthine
oxidase system by 30%. Esculin also showed an antioxidant effect in a model of
Fe2+-induced lipid peroxidation. Cytogenetic analysis showed that epirubicin had a marked
infl uence on the structure of metaphase chromosomes of normal bone marrow cells. Inclusion
of esculin in the treatment protocol failed to ameliorate the epirubicin-induced antiproliferative
effects and genotoxicity in bone marrow cells.

CONCLUSION: In this study the ability of the coumarin glucoside esculin to scavenge superoxide
radicals and to decrease Fe-induced lipid peroxidation was documented. However,
despite the registered antioxidant effects the tested compound failed to exert cytoprotection
in models of anthracycline-induced genotoxicity in bone marrow cells. The results of
this study warrant for more precise further evaluation of esculin, employing different test
systems and end-points and a wider range of doses to more precisely appraise its potential
role as a chemoprotective/resque agent.
Kinetics of methane oxidation in selected mineral soils
Authors: Walkiewicz A. , Bulak P. , Brzeziñska M. , Włodarczyk T. , Polakowski C. 
Published: February 2013

Abstract
The kinetic parameters of methane oxidation in three mineral soils were measured under laboratory conditions. Incubationswere preceded by a 24-day preincubationwith 10%vol. of methane. All soils showed potential to the consumption of added methane. None of the soils, however, consumed atmospheric CH4. Methane oxidation followed the Michaelis-Menten kinetics, with relatively low values of parameters for Eutric Cambisol, while high values for Haplic Podzol, and especially for Mollic Gleysol which showed the highest methanotrophic activity and much lower affinity to methane. The high values of parameters for methane oxidation are typical for organic soils and mineral soils from landfill cover. The possibility of the involvement of nitrifying microorganisms, which inhabit the ammonia-fertilized agricultural soils should be verified.
Ice Hockey Goaltender Rehabilitation, Including On-Ice Progression, After Arthroscopic Hip Surgery for Femoroacetabular Impingement
Authors: Pierce Casey M. , LaPrade Robert F. , Wahoff Mike , O'Brien Luke , Philippon Marc J. 
Published: February 2013

Synopsis Ice hockey goaltenders, especially those who employ the butterfly technique, are a specialized population of athletes because of the unique physical demands that the position places on their lower extremities, specifically at the hip. It is no surprise that hip injuries are a common occurrence among goalies. A review of the biomechanical literature has demonstrated that stresses on the hip while in flexion and end-range internal rotation, the position goaltenders commonly use, put the hip at risk for injury and are likely a major contributing factor to overuse hip injuries. The stress on a goaltender's hip can potentially be further intensified by the presence of bony deformities, such as cam- or pincer-type femoroacetabular impingement, which can lead to chondrolabral junction and articular cartilage injuries. There have been few published reports of goaltenders' functional outcomes following femoroacetabular impingement surgery, and, to our knowledge, no studies have yet identified the specific challenges presented in the rehabilitation of goaltenders following femoroacetabular impingement surgery. The present clinical commentary describes a 6-phase return-to-skating program developed as part of a rehabilitation protocol to aid hockey goaltenders recovering from surgery. Level of Evidence Therapy, level 5. J Orthop Sports Phys Ther 2013;43(3):129–141. Epub 12 February 2013. doi:10.2519/jospt.2013.4430
The Whakatane Mechanism: Promoting Justice in Protected Areas Emmanuel Freudenthal, in Collaboration with Maurizio Farhan Ferrari, Justin Kenrick and Adrian Mylne
Authors: Freudenthal Emmanuel , Ferrari Maurizio Farhan , Kenrick Justin , Mylne Adrian 
Published: February 2013

Abstract
Since 2003, there has been progress in global policy towards changing conservation from a model that often excluded peoples to a "new paradigm" that respects human rights and recognises that local communities are the cornerstone of healthy ecosystems. Nevertheless, the implementation of these decisions has been very patchy. In order to remedy that, the International Union for Conservation of Nature (IUCN) has established the Whakatane Mechanism, an initiative to assess respect for human rights in protected areas in order to address conflicts between management authorities and indigenous peoples.
How to Manage the Inclusion of E-Learning in Learning Strategy: Insights from a Turkish Banking Institution
Authors: Kok Ayse 
Published: February 2013

The purpose of this research paper is to demonstrate how a banking institution in Turkey is managing the inclusion of e-learning in its learning strategy. The case study demonstrates that the adoption of e-learning is actually influencing bankâ??s learning strategy, and that the simple delivery through technology cannot be sustained as a separate form of training, an appendix to traditional instructor-led activities. To be successful, it has to be seen as a part of a complete learning architecture that includes a variety of tools, approaches, and a coherent learning culture. The analysis shows two emerging phenomena:

â?¢ A different degree of success of the e-learning initiative depending upon its coherence with the organizational culture, and the bankâ??s strategy
â?¢ A changing balance of classroom training and e-learning in relationship to the adoption of the LMS adoption in each department
Stem cell transplant: An experience from eastern India
Authors: Mukhopadhyay A , Gupta P , Basak J , Chakraborty A , Bhattacharyya D , Mukhopadhyay S , Roy U 
Published: February 2013

Abstract
Background: Hematopoietic stem cell transplant using human leukocyte antigen (HLA)-matched sibling or unrelated bone marrow, or related or unrelated cord blood has been performed successfully to treat patients with different types of hematological malignancies, genetic disorders and hereditary immune deficiencies. Since 1983, stem cell transplantation has been carried out in different institutes of India. But, till then, no transplantation was performed in eastern India. Materials and Methods: Our present study is reporting for the first time stem cell transplantation in eastern India. From August 2000 to June 2011 (with a 3-year gap for up-gradation), we have performed a total of 22 transplants. Thirteen patients (M:F:9:4) with indications of aplastic anemia, thalassaemia, acute myeloid leukemia and chronic myeloid leukemia underwent allogenic transplant, whereas autologous transplant was performed for nine patients (M:F:2:1) of multiple myeloma, Hodgkin′s and non-Hodgkin′s lymphoma and neuroblastoma. The median age of the patients was 19.6 years, with a range of 5 years 8 months to 52 years. Fourteen patients received myeloablative conditioning regime whereas eight patients received immunosuppressive and less myeloablative protocol. Sources of stem cells in case of allogenic transplant are bone marrow and related or unrelated umbilical cord blood and in case of autologous transplant, these are peripheral blood stem cells or self-bone marrow. Standard prophylactic medication was followed prior to transplants. Results: A disease-free survival of 68.18% and overall survival of 86.3% were seen at the median follow-up period of 4.6 years. Common post-transplant complications were mucositis, infection, venoocclusive disease, graft versus host disease, hemorrhagic cystitis, etc. Conclusion: The use of cord blood as a source of stem cells has been proved inferior as compared with the bone marrow stem cell source in cases of thalassaemia in our institute and thus is not recommended for thalassaemia. But, it has been proved to be a very useful and effective stem cell source (both related and unrelated cord blood) in cases of aplastic anemia and other immunological disorders.