bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intramyocardial transplantation of cardiac mesenchymal stem cells reduces myocarditis in a model of chronic Chagas disease cardiomyopathy
Authors: Silva Daniela Nascimento , de Freitas Souza Bruno Solano , Azevedo Carine Machado , Vasconcelos Juliana Fraga , Carvalho Rejane Hughes , Soares Milena Botelho Pereira , dos Santos Ricardo Ribeiro 
Published: July 2014

Abstract
Introduction
New therapeutic options are necessary for patients with chronic Chagas disease, a leading cause of heart failure in Latin American countries. Stem cell therapy focused on improving cardiac function is a promising approach for treating heart disease. Here, we evaluated the therapeutic effects of cardiac mesenchymal stem cells (CMSCs) in a mouse model of chronic Chagas disease.

Methods
CMSCs were isolated from green fluorescent protein (GFP) transgenic C57BL/6 mouse hearts and tested for adipogenic, osteogenic, chondrogenic, endothelial, and cardiogenic differentiation potentials evaluated by histochemical and immunofluorescence techniques. A lymphoproliferation assay was performed to evaluate the immunomodulatory activity of CMSCs. To investigate the therapeutic potential of CMSCs, C57BL/6 mice chronically infected with Trypanosoma cruzi were treated with 106 CMSCs or saline (control) by echocardiography-guided injection into the left ventricle wall. All animals were submitted to cardiac histopathological and immunofluorescence analysis in heart sections from chagasic mice. Analysis by quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was performed in the heart to evaluate the expression of cytokines involved in the inflammatory response.

Results
CMSCs demonstrated adipogenic, osteogenic, and chondrogenic differentiation potentials. Moreover, these cells expressed endothelial cell and cardiomyocyte features upon defined stimulation culture conditions and displayed immunosuppressive activity in vitro. After intramyocardial injection, GFP+ CMSCs were observed in heart sections of chagasic mice one week later; however, no observed GFP+ cells co-expressed troponin T or connexin-43. Histopathological analysis revealed that CMSC-treated mice had a significantly decreased number of inflammatory cells, but no reduction in fibrotic area, two months after treatment. Analysis by qRT-PCR demonstrated that cell therapy significantly decreased tumor necrosis factor-alpha expression and increased transforming growth factor-beta in heart samples.

Conclusions
We conclude that the CMSCs exert a protective effect in chronic chagasic cardiomyopathy primarily through immunomodulation.
Corporate Transparency and the Impact of Investor Sentiment on Stock Prices
Authors: Firth Michael , Wang Kailong (Philip) , Wong Sonia ML 
Published: July 2014

Using China's stock market as the testing venue, this study examines how corporate transparency helps explain the sensitivity of stock prices to general investor sentiment. We find that firms with low corporate transparency, measured by a battery of proxies including state ownership, the prevalence of related party transactions, accrual-based earnings management, audit opinions, and the quality of audit firms, are more affected by investor sentiment than are firms with high corporate transparency. Overall, our findings highlight the importance of corporate transparency in mitigating the effects of investor sentiment on stock prices. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2014.1911 . This paper was accepted by Brad Barber, finance.
Microsatellite Instability Detection by Next Generation Sequencing
Authors: Salipante Stephen J , Scroggins Sheena M , Hampel Heather L , Turner Emily H , Pritchard Colin C 
Published: July 2014

Abstract

BACKGROUND
Microsatellite instability (MSI) is a useful phenotype in cancer diagnosis and prognosis. Nevertheless, methods to detect MSI status from next generation DNA sequencing (NGS) data are underdeveloped.

METHODS
We developed an approach to detect the MSI phenotype using NGS (mSINGS). The method was used to evaluate mononucleotide microsatellite loci that were incidentally sequenced after targeted gene enrichment and could be applied to gene or exome capture panels designed for other purposes. For each microsatellite locus, the number of differently sized repeats in experimental samples were quantified and compared to a population of normal controls. Loci were considered unstable if the experimental number of repeats was statistically greater than in the control population. MSI status was determined by the fraction of unstable microsatellite loci.

RESULTS
We examined data from 324 samples generated using targeted gene capture assays of 3 different sizes, ranging from a 0.85-Mb to a 44-Mb exome design and incorporating from 15 to 2957 microsatellite markers. When we compared mSING results to MSI-PCR as a gold standard for 108 cases, we found the approach to be both diagnostically sensitive (range of 96.4% to 100% across 3 panels) and specific (range of 97.2% to 100%) for determining MSI status. The fraction of unstable microsatellite markers calculated from sequencing data correlated with the number of unstable loci detected by conventional MSI-PCR testing.

CONCLUSIONS
NGS data can enable highly accurate detection of MSI, even from limited capture designs. This novel approach offers several advantages over existing PCR-based methods.
Unstable grounds: Investigating ulterior spaces for practising
Authors: Robbins Felix 
Published: July 2014

Abstract
This article investigates alternative ways of working. It is a reflection on the contradictions of architectural practice and the opportunities for design that acknowledges these contradictions productively. The article continues an investigation into the construction of an architectural project – the contradictory requirements for the ‘construction’ of architecture and the opportunities in dissolving these requirements by design. It develops as an enquiry into the possibilities of actively acknowledging the contradictions and ambiguities of the discipline as a means to go on, as well as design that operates within the slippages, translations and movements between the ‘construction of a project’ to tentatively speculate on alternative and temporary locations and spaces of practice. It elaborates on ongoing design work of a ‘dwelling’ and the explicit processes, choices and techniques that move between the construction of narrative, site, material and space/time. The article argues that the discipline of architecture is unavoidably ungrounded – with the relevance and approach to practising lying exposed within the wider context of cultural production and a ‘deluge’ of multiple and relative shifting landscapes of ‘project’. It argues, however, that this does not justify merely reconstructing the grounds of the discipline in other terms – whether that be nostalgic, technological or superficial. Instead, it argues that other spaces for practising must be inhabited – spaces that make use of the ‘deluge’ and the ambiguities of practice and suggest alternative approaches to understanding and creating a sufficiency and productivity of making architecture.
Fabricating a New Image: Imperial Tents in the Late Ottoman Period
Authors: Dimmig Ashley 
Published: July 2014

Abstract
During the first centuries of Ottoman rule, sultans were constantly on the move and thus required transportable lodging in the form of the tent. As the nomadic dynasty grew into an empire, Ottoman tents quickly evolved into complex constructions that scholars often describe as ‘mobile palaces’. These extravagant tents continued to be used until the end of the Empire, and throughout the centuries, evolved stylistically in tandem with other imperial art forms such as permanent architecture and painting. In the eighteenth and nineteenth centuries, tentmakers had a fantastically rich and varied repertoire of visual elements at their disposal, some of which were adapted from international artistic milieus, and still others that developed domestically. In the sprawling landscape of late Ottoman Istanbul, tents functioned as transitional spaces between indoors and outdoors, like mobile pleasure pavilions, through which members of the court could enjoy the sensory pleasures of nature. Moreover, tents of all shapes and sizes functioned as interim palatial architecture and lavish silken stage settings for imperial ceremonies, which in the last centuries of Ottoman rule were employed to propagate the sultan’s power through his visibility.
Relocating to Hawai‘i: Dwelling with Islamic art at Doris Duke’s Shangri La
Authors: Bush Olga 
Published: July 2014

Abstract
This article explores Doris Duke’s (1912–93) practices as the ‘creative persona’ in building Shangri La, both her home in Hawai‘i and the fifth largest collection of Islamic art in America. Discussion begins with historical contextualization. A brief review of elite collecting in the 1930s extends the timeline of American orientalism to Duke’s project at Shangri La. Enabled by the emergence of interior design as a field for women’s creativity, her practices as the first major western female collector of Islamic art are considered against American orientalism’s gendered slant. Thereafter, the discussion turns to theoretical concerns. First, Duke’s deliberately hybrid spaces, mixing Islamic art from various regions and also combining historical objects with replicas, is studied as the creation of an Islamicate dwelling place, which, contrary to the colonial bases of orientalism, recognized the contemporaneity of the Islamic world. Duke’s practices of replication and recollection suggest relocation as the conceptual mode in which mobile objects create a sense of the transitory that supplants static architecture. Finally, the concept of relocation enables an examination of Duke’s major innovation. She moves Islamic tentage indoors to express her understanding of transitional space in Islamic architecture relocated to its setting in Hawai‘i.
Exhibition Reviews
Authors: Becker Lutz , Quraishi Fatima , Skurvida Sandra , Valor Magdalena 
Published: July 2014

Abstract
‘The House is Black’, Rose Issa Projects, London, United Kingdom, October 14–November 14, 2013
‘Interwoven Globe: The Worldwide Textile Trade, 1500–1800’, Metropolitan Museum of Art, September 16, 2013–5 January 2014
‘Iran Modern’, Asia Society, New York City, September 6, 2013–January 5, 2014
‘Nur: Light in Art and Science From the Islamic World’, Focus-Abengoa Foundation, Seville, Spain, October 2013–March 2014
‘Conservative nativist’ Chinese art in Hong Kong and Mainland China
Authors: Vigneron Frank 
Published: July 2014

Abstract
In the discourse on ‘nativism’ and ‘cultural conservatism’, now dominant in Mainland China, the position of ‘traditional’ art, and especially painting made with Chinese ink, has been promoted by official institutions like the China Artists Association, thus emphasizing the support of the state. The discourse accompanying the appreciation and creation of Ink art in Mainland China has thus been stated with an often extremely nationalistic attitude. When Ink art belongs to art practices seen as ‘contemporary’ and therefore not ‘traditional’ in Mainland China, it is generally ignored by official, state-sponsored institutions. Both ‘traditional’ and ‘contemporary’ Ink art practices also coexist in Hong Kong, but even the traditional is generally defended without recourse to the kind of excessive cultural nationalism prevalent in the Mainland (even though there is always the possibility for Hong Kong nativist conservatives to exhibit in China, where they can rely on the official promotion of their art). Hong Kong public and private art institutions have also defended Ink art, thus redefining its function and boundaries. The role of M+ and the museums of the Leisure and Cultural Services Department have been instrumental in the promotion and expansion of the field of Ink art.
Explorations of genealogy in experimental art in China
Authors: Moner Laia Manonelles 
Published: July 2014

Abstract
This article aims to show how different artists propose an approach to their own family tree and, at the same time, examine new family relationships currently being established in China. These creators explore various issues such as maternity, paternity, and agreements and disagreements between grandparents, parents and children. Other realities that are reflected in their works are the processes of adoption, and how the one-child policy – that began in the 1970s – has affected and currently affects families and Chinese society.
Artists such as Song Dong, He Chengyao, Xing Danwen, Lin Tianmiao, Ma Qiusha, He Chongyue and O Zhang and Shen Yuan deal with their own genealogy in their artworks, linking the individual and the collective, the personal and the social. Their art becomes a tool to focus on different problems that remain in the domestic and intimate sphere. Here, the transition from private to public becomes a political act. The objective is to question, to create spaces for debate and reflection.
Between film and TV: Cursilería and the return of politics in 1970s’ Spain
Authors: Medina Alberto 
Published: July 2014

Abstract
Only recently have some critics started challenging the image of an elitist New Spanish Cinema in the 1960s and 1970s, disconnected from the general public and in indirect complicity with Francoist strategies of international self-promotion. Within that trend, the fact that the most important names of the New Spanish Cinema were simultaneously working as publicists, scriptwriters or TV directors allows us to map a more complex reality. Fascinated with a new medium full of unknown possibilities, those directors assimilated new techniques and the possibilities of dealing with a different and much bigger audience. The TV experience was not only the point of departure for a renewed aesthetic, but also for a more complex positioning of film as a political tool that was conceived then not in radical opposition to Francoist mass media but as strategically linked to them. This analysis of a paradigmatic film of the period in dialogue with TV aesthetics, Martín Patino’s Canciones para después de una Guerra/Songs for After a War (1976), opens the possibility of a re-contextualization of TV ‘cursilería’ and its transformation into modern kitsch as an innovative aesthetic and, simultaneously, an oppositional discourse.
Times of transition in Hispanic cinemas
Authors: Palacio Manuel , Labayen Miguel Fernández 
Published: July 2014

Abstract
This special issue of Studies in Spanish & Latin American Cinemas contains selected contributions presented at the international conference ‘In Transition: Historical, Political and Cultural Changes in Cinema and Television’, held in November 2012 at the Universidad Carlos III de Madrid. Both the conference and the articles included in the following pages explore technological connotations of ‘the transitional’ from historically conscious and comparative perspectives in an effort to better understand and appreciate the impact of transnationalism for the field of Hispanic and Latin American studies. While ‘the transnational’ has already been explored by other scholars in film and media studies, the articles to follow add a strong political dimension to the field as they present a variety of case studies of transnational practices in the cinemas of Spain and Latin America. By placing the studies of transnational activities in Spanish and Latin American contexts, we are better able to assess the implications of these different types of transition for the Hispanic world, both from a national and a transnational level.
Reflexiones sobre los medios audiovisuales en las publicaciones clandestinas del PCE y de las comisiones de trabajadores y trabajadoras del cine y la televisión
Authors: Souto Xose Prieto 
Published: July 2014

Abstract
This article explores the theoretical writings on cinema and television that were published in the underground media promoted by the Partido Comunista de España (PCE, Communist Party of Spain) and in a series of bulletins edited by workers’ commissions devoted to the audio-visual sector. This research takes the 1st International Symposium on Film Schools as a starting point and ends in 1977, when the PCE was legalized in Spain.
Don’t miss a bloody thing: [REC] and the Spanish adaptation of found footage horror
Authors: Rowan-Legg Shelagh M. 
Published: July 2014

Abstract
Although found footage as aesthetic expression was common in documentary and avant-garde cinema, it was not until the end of the 1990s that it was adapted for use in the horror film. This sub-genre gave film-makers a new means of cognitive and emotional connection with the spectator. Paco Plaza and Jaume Balagueró’s films [REC] (2007) and [REC] 2 (2009) recycled the format, creating films rooted in the national while at the same time projecting a post-national image of the genre. [REC] turned the found footage film into a commentary on Spanish tabloid television, its vapid journalistic presentation and the public’s appetite for scandal. [REC] 2 adapted the form further, expanding it from a single to several cameras, and expanding the narrative to issues of political and religious ideology. The [REC] films present a directly lived representation through found footage, where the spectator has limited scope of knowledge that goes beyond mere subjectivity to the limits of visualization and knowledge the form depicts. [REC] moves beyond the use of found footage as a tool for horror, and transitions it into a commentary on filmic presentation and spectatorial engagement, re-positioning contemporary Spanish horror film into a post-national context.
Book Reviews
Authors: Camí-Vela María , Davies Ann , Whittaker Tom 
Published: July 2014

Abstract
The cinema of Iciar Bollaín, Isabel Santaolalla (2012) Manchester and New York: Manchester University Press, 272 pp., ISBN 978-0-7190-8058-6 (hbk), £65
Spanish horror film, Antonio Lázaro-Reboll (2012) Edinburgh: Edinburgh University Press, 308 pp., ISBN 978 0 7486 3638 9, (hbk), £65
Alejandro Amenábar, Barry Jordan (2012) Manchester: Manchester University Press, 336 pp., ISBN 978-0-7190-7589-6 (hbk), £65
Looking amid the rubble: New Spanish documentary film and the residues of urban transformation (Joaquim Jordà and José Luis Guerín)
Authors: Moreno-Caballud Luis 
Published: July 2014

Abstract
Spanish documentary film has experienced an extraordinary flourishing during the beginning of the twenty-first century, in parallel with the increasing democratization of audiovisual means of production. In this essay I link this democratization with Spanish documentary’s tendency to become a collective social experiment that emphasizes interactions between film-makers and filmed social actors. In particular, I analyze the case of films dealing with urban transformation, because their capacity of intervening in the processes of social construction of reality is especially significant.
Reconfiguring gender and the representation of the Soldadera in the Mexican revolution film
Authors: Pick Zuzana 
Published: July 2014

Abstract
In keeping with the meticulous enterprise of rewriting women’s history in Mexico, rescuing their stories and re-inscribing their identities, undertaken in the last two decades by cultural historians, feminist writers and film scholars, this article proposes a detailed analysis of the soldadera as a protagonist in La negra Angustias (The Black Angustias, Matilde Landeta, Mexico 1949) and La soldadera (The Camp Follower, José Bolaños, Mexico 1966). Whether portrayed as a combative mulatta colonel who takes charge of her destiny or a suffering fair-skinned bride-to-be doomed to drift aimlessly, she is restored to history. Although the directors draw on existing depictions of the archetypal female of Mexican war culture and revolution, their films reveal how the identity and social reality of their characters have been shaped by discrimination and misogyny.
Report on Madrid de Cine-Spanish Film Screenings
Authors: Smith Paul Julian 
Published: July 2014

Abstract
This report covers the eighth edition of Madrid de Cine-Spanish Film Screenings, the major marketplace for Spanish cinema, which took place on 17–19 June 2013. Based on industry sources at the event, it offers a survey of Spanish film over the previous year and identifies five trends in current production: post-apocalyptic films, romantic dramedies, genre movies, auteurist films and titles that are innovative in their distribution and exhibition.
Book Reviews
Authors: Jordan Barry , Smith Paul Julian , Zecchi Barbara , del Mar Azcona María 
Published: July 2014

Abstract
Companion to Spanish Cinema, Jo Labanyi and Tatjana Pavlovic´ (eds) (2013) Oxford: Wiley Blackwell, 638 pp., ISBN 978-14051-9438-9 (hbk), £120
Aesthetics and Politics in the Mexican Film Industry, Misha MacLaird (2013) New York: Palgrave Macmillan, 230 pp., ISBN 978-1137008060 (hbk), $90.
Spanish Spaces: Landscape, Space and Place in Contemporary Spanish Culture, Ann Davies (2012) Liverpool: Liverpool University Press, vii + 190 pp., ISBN 978–184631–822–1 (hbk), $99.95
Cinema on the Periphery: Contemporary Irish and Spanish Film, Conn Holohan (2010) Dublin and Portland: Irish Academic Press, 198 pp., ISBN 978-0716530220 €60 (hbk); €29.95
The Impact of Voter Uncertainty and Alienation on Turnout and Candidate Policy Choice
Authors: Brown Natalya R. 
Published: July 2014

AbstractFormal models of elections typically assume that voters are sure of their ideal points on the policy spectrum. Meanwhile, the empirical evidence suggests that voters are often uncertain about their ideal positions. In addition, alienation appears to play a key role in explaining voter turnout in elections. Using a spatial model that incorporates abstentions and the concepts of alienation and tolerance, I show that a positive correlation between extreme policy preferences and certainty among voters can affect voter turnout and result in the divergence of candidate policy choices.
The acquisition of determiners in child L2 German
Authors: Schönenberger Manuela 
Published: July 2014

Abstract The object of this study is to test Meisel’s (2009) hypothesis that there is a sensitive phase in language acquisition that ends around age 4. Early L2 acquisition may therefore already show differences from L1 acquisition. To test this hypothesis, determiner production in the naturalistic speech of four successive bilingual Turkish-German children recorded during free-play situations was compared to that of monolingual German children discussed in the literature. The successive bilinguals had an age of onset of German between 3 and 4 years and were studied over a period of 20 months. Determiner production was examined because Turkish, as opposed to German, does not have an article system. Determiner omission and incorrect article use were considered. A clear difference emerged in determiner omission, but not in article misuse. After some initial variability in determiner production, determiner omission by the monolingual children was found to gradually fall below 10 per cent, while a plateau effect could be observed in the bilingual children. There was no clear evidence for article misuse in either the L1 or the child L2 data. Our findings about determiner omission suggest that early L2 acquisition differs from L1 acquisition. It is unclear, however, whether the child L2 learners will persist in omitting determiners from obligatory contexts, since data collection was ended while the children were still in the process of acquiring German