bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving the Carbonation of Steel Slags Through Concurrent Wet Milling
Authors: de Schutter Anthony , Ceyssens Luka , Granata Giuseppe , Van Gerven Tom 
Published: August 2024

AbstractThis work studies mineral carbonation of steel slags with the aim to reduce the amount of slag that is landfilled. Besides permanently storing carbon dioxide (CO2), carbonating the slags can improve their quality for use in beneficial applications and reduces the leaching of harmful heavy metals. In order to intensify the mineral carbonation process, mechanical activation is used to improve both the carbonation kinetics and yield. The milling is performed in a planetary ball mill which allows for high-intensity grinding, resulting in a fast reduction of the particle size and quick amorphization and disturbance of the crystal structure, allowing high reaction rates to be achieved. The effects of the three main processing parameters of a planetary ball mill—bead-to-powder ratio $$R$$
R
, bead size $$D$$
D
and milling speed $$S$$
S
—are investigated. Under optimal conditions, more than 50% of the maximum CO2 uptake is achieved in only 6 min, representing a very significant improvement over regular slurry carbonation. Quantitative XRD allows to identify the reactivity of the different crystalline phases present in the slag under different milling conditions. With the help of a mass balance, the formation of an inert outer layer consisting of silica (SiO2) is confirmed. This explains both the shell diffusion mechanism controlling the carbonation reaction and the total conversion being limited to 50–60%.
Graphical Abstract
Determining Hypercentral Hall Subgroups in Finite Groups
Authors: Sotomayor V. 
Published: August 2024

AbstractLet G be a finite group, and let $$\pi $$
π
be a set of primes. The aim of this paper is to obtain some results concerning how much information about the $$\pi $$
π
-structure of G can be gathered from the knowledge of the sizes of conjugacy classes of its $$\pi $$
π
-elements and of their multiplicities. Among other results, we prove that this multiset of class sizes determines whether G has a hypercentral Hall $$\pi $$
π
-subgroup.
Mechanical performance of liquid cold-poured interlayer adhesives in comparison to PVB, EVA, and ionomers
Authors: Offereins Dominik , Pauli Alexander , Siebert Geralt 
Published: August 2024

AbstractCurrently, liquid cold-poured adhesives are infrequently used as interlayers of laminated or laminated safety glass in structural glass applications, despite their inherent benefits. The potential advantages of these materials are characterized by easy handling, rapid curing devoid of elevated temperature or pressure requirements, and consequently, a comparatively low energy demand. Despite the prolonged availability of certain products in the market, comprehensive scientific inquiry into their mechanical and thermal material characteristics remains limited. In this paper, two specific liquid cold-poured interlayer adhesives are investigated for their mechanical material properties in an extensive test regime. To be able to classify the characteristic values of the adhesives within a correct framework, the materials currently holding the largest market share, including Polyvinyl Butyral (PVB), Ionomers, and Ethylene Vinyl Acetate (EVA), are also subjected to the experimental program. The temperature dependence of the material behavior is explored through Dynamic Mechanical Thermal Analysis (DMTA) experiments. Furthermore, the time-dependent material behavior at large deformations is scrutinized using various methodologies, such as tensile tests at different strain rates, cyclic tests, creep tests, and relaxation tests, all conducted in uniaxial tension mode. The outcomes of all tests led to promising results for one of the adhesives with advantages over those of PVB and EVA.
Challenging dominant education paradigms: posthuman feminist inspirations towards alternate pathways for decolonising the curriculum
Authors: Simmonds Shan 
Published: August 2024

AbstractSouth Africa’s curriculum, and education system at large, remains humanistic and dominated by Western Eurocentric ways of thinking, doing and being. The ongoing protest action in higher education has made explicit the inequalities that continue to keep epistemic violence, Eurocentrism, and human exceptionalism intact. Central to this protest action has been the need for curriculum inquiry to reinvent itself and go against the pedagogical grain by advocating for a decolonised curriculum. However, the decolonial turn has largely been a structural exercise of abstract and rhetoric intensity fueled by a language of critique that is entrapped in discursive tendencies that inhibit the type of radicalism needed for it to invigorate alternatives that can challenge dominant education paradigms. This article is inspired by posthuman feminist theory that troubles the logic of advanced capitalism, epistemic injustice and dominant education paradigms. Invoked by new materialism, intra-actions of our becoming within and as part of the world are the deep entanglements of ethics, knowing and being that can spur scholarly activism. Four curriculum studies scholar activists shared their narratives of how they are enacting their curriculum to challenge dominant education paradigms. Their lived experiences as material, relational, embodied and embedded incite posthuman tendencies of what it means to teach to transgress. Experimenting with transversal transgressions this article attempts at a non-anthropocentric, feminist inspired perspective for curriculum inquiry to find alternative pathways for decolonising the curriculum so that it can rise to the challenges of our time.
Pastoral grasses and legumes as potential host plants for fall armyworm Spodoptera frugiperda (J.E. Smith) development.
Authors: Adnan Saleh Mohammad , Cattermole Holly , Saligari Kim , Spafford Helen 
Published: August 2024

AbstractThe fall armyworm, Spodopterafrugiperda (J.E. Smith) (Lepidoptera: Noctuidae) is a highly polyphagous, migratory pest native to the tropical and subtropical region of Americas. Grass crops particularly corn have been most heavily impacted since S. frugiperda invaded Australia in 2020. In northern Western Australia, S. frugiperda is primarily a problem in dry season (May to October) crops when there are abundant host plants available in monocultures. During the wet season (November to April) it is not known what host plants may support larval growth and development. Accordingly, this present study undertook a no-choice feeding bioassay to assess larval and pupal development on several grasses and legumes that are present over the wet season in northern Western Australia to evaluate their potential as suitable host plants for S. frugiperda. Maize (control) and sorghum were the most suitable hosts for S. frugiperda development as they supported greater larval and pupal survival, heavier larvae and pupae, and shorter development period. Following maize and sorghum, pastoral grasses, particularly blue grass, and a weedy grass, barnyard grass, had comparable effects on larval and pupal development. Legume pastures (Cavalcade, butterfly pea, and siratro) were unsuitable hosts in this bioassay as very few larvae completed their development to adults. This study demonstrates the potential for rangeland pasture grasses and weedy grasses as wet season host plants for S. frugiperda. They provide the necessary green bridge for S. frugiperda populations to survive. It is recommended that pastoralists monitor their grass forage for S. frugiperda and consider management if significant reductions in biomass are detected.
A study on the improvement of ion conductivity of lithium aluminum titanium phosphate-based solid-state electrolyte by the addition of divalent cations
Authors: Jeong Wonjong , Liu Liyu , Lim Hyung-Sik , Chung Jaeyeop , Chen Kai , Ryu Bong Ki 
Published: August 2024

Abstract
Na like super ionic conductors (NASICON)-structure Li1.3Al0.3Ti1.7(PO4)3 solid electrolyte have attracted attention as high ion conductivity and chemical stability. The M1–M2 voids between the TiO6 octahedra and PO4 tetrahedra in a Li1.3Al0.3Ti1.7(PO4)3-based solid electrolyte is a major path for lithium-ion conduction, and it can be widened to increase lithium-ion conductivity by doping. In this study, divalent ions are doped into the Li1.3Al0.3Ti1.7(PO4)3-based electrolyte and widened ion-conduction path and improved ion conductivity. Making doped Li1.3Al0.3Ti1.7(PO4)3 samples starts with melting, then transformed into glass, pulverized, and then subjected to uniaxial compression molding and sintering, after which they are analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS), and their impedance resistances were measured. The LiTi2(PO4)3 is generated by thermal treatment and crystallized to form an electrolyte whose lattice parameter values depend on the dopant ion and its content, with each divalent ion distorting the lattice and the M1–M2 bottleneck structure differently. Only Mg2+ doping led to a structural change that increases Li-ion conductivity to 1.55 × 10−3 S/cm at 5 mol% of magnesium ion, with the observed threefold increase in conductivity compared to the 4.73 × 10−4 S/cm ion conductivity of LATP ascribable to a widening of the ion-conduction path. Overall, doping an LATP-based solid electrolyte with an appropriate divalent cation is a promising way of improving performance in a manner that has various applications.
Ecosystem restoration and EU Law: an introduction to the symposium
Authors: Chiti Edoardo 
Published: August 2024

AbstractThis short Introduction outlines the purpose and structure of the Symposium on Ecosystem Restoration and EU Law. It opens by highlighting the potential relevance of the ecological move taken by the EU political institutions in the framework of the Green Deal. It then presents the issues addressed in the Symposium and the main overall argument emerging from its four contributions: whilst the EU ecological policy reflects the intention to shift from the traditional understanding of environmental protection as social regulation to a genuinely ecological and holistic vision, the functional rationale of such a move remains, for the moment, elusive and under-specified. Clarifying such rationale is an inescapable but complex task, as it requires a fresh discussion on the relationship between law and ecology, as well as a true understanding of the implications of ecosystem restoration for the evolving features of the EU polity.
Reservoir Operating Rules to Create Effective Fish Migration Passages in a Reservoir
Authors: Yang B. H. , Yin X. A. , Gao Z. J. , Liu H. R. , Xu Z. H. 
Published: August 2024

AbstractLow flow velocity disrupts the potential fish migration passages in a reservoir, and causes reservoirs to become labyrinths for migratory fish. Previous studies showed that fish migration passages in a reservoir can be restored by modifying reservoir operation. However, reservoir operating rules that are specifically designed to support fish migration have not been established, leading to low success for fish migration and high socioeconomic losses. In this research, we established new reservoir operating rules to improve the migration success rate while also reducing socioeconomic losses. Under the new rules, two parameters (reservoir water level and predicted reservoir inflows) were adapted to trigger water releases to open migration passages. The two parameters were optimized by considering hydrological processes, fish migration processes below the dam, the swimming ability of fish, and the socioeconomic benefits provided by the reservoir. We used data from China's Danjiangkou Reservoir to test the effectiveness of the proposed method. We found that the new method can not only improve the migration success rate (from 0.1% to 4.2%), but can also slightly reduce the reservoir's socioeconomic losses (by 3.7%–7.0%). The new method effectively balances the needs of fish migration with the need for socioeconomic development in the areas surrounding dammed rivers.
On the Relationship Between Condensed Water Content and Liquid‐Ice Mixing Homogeneity in Mixed‐Phase Stratiform Clouds
Authors: Deng Yuting , Yang Jing , Yin Yan , Lu Chunsong , Chen Baojun , Dong Xiaobo , Wang Zhien , Zhang Bo , Bao Xinghua , Hou Tuanjie 
Published: August 2024

AbstractAs a key factor influencing the cloud life cycle and radiative properties, liquid‐ice mass partitioning remains a major source of uncertainties in modeling mixed‐phase clouds. One of the unresolved problems is that liquid‐ice mixing is highly inhomogeneous, but it has not been well understood and quantified for parameterization. In this study, the liquid‐ice mixing homogeneity (χ) is quantified using the information‐theoretic entropy based on airborne measurements. It is demonstrated that χ is positively correlated with the condensed water content (CWC). Cloud regions with low χ are consist of liquid and ice clusters. With the increase in χ, the size and frequency of continuous mixed‐phase clusters increase. For a given CWC, χ is lower at relatively warm temperatures as sedimentation of large ice crystals can enhance the inhomogeneity. The strong positive relationship between CWC and χ indicates CWC should be considered when parameterizing the liquid‐ice mixing in models.
Potassium voltage-gated channel subfamily H member 2 (KCNH2) is a promising target for incretin secretagogue therapies
Authors: Yuan Ying-Chao , Wang Hao , Jiang Ze-Ju , Liu Chang , Li Qi , Zhou Si-Rui , Yang Jin-Kui 
Published: August 2024

AbstractDerived from enteroendocrine cells (EECs), glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are pivotal incretin hormones crucial for blood glucose regulation. Medications of GLP-1 analogs and GLP-1 receptor activators are extensively used in the treatment of type 2 diabetes (T2D) and obesity. However, there are currently no agents to stimulate endogenous incretin secretion. Here, we find the pivotal role of KCNH2 potassium channels in the regulation of incretin secretion. Co-localization of KCNH2 with incretin-secreting EECs in the intestinal epithelium of rodents highlights its significance. Gut epithelial cell-specific KCNH2 knockout in mice improves glucose tolerance and increases oral glucose-triggered GLP-1 and GIP secretion, particularly GIP. Furthermore, KCNH2-deficient primary intestinal epithelial cells exhibit heightened incretin, especially GIP secretion upon nutrient stimulation. Mechanistically, KCNH2 knockdown in EECs leads to reduced K+ currents, prolonged action potential duration, and elevated intracellular calcium levels. Finally, we found that dofetilide, a KCNH2-specific inhibitor, could promote incretin secretion in enteroendocrine STC-1 cells in vitro and in hyperglycemic mice in vivo. These findings elucidate, for the first time, the mechanism and application of KCNH2 in regulating incretin secretion by EECs. Given the therapeutic promise of GLP-1 and GIP in diabetes and obesity management, this study advances our understanding of incretin regulation, paving the way for potential incretin secretagogue therapies in the treatment of diabetes and obesity.
Crizotinib and its enantiomer suppress ferroptosis by decreasing PE-O-PUFA content
Authors: Cen Si-Yu , Lin Fang , Li Xuan , Hu Yanglin , Liu Jin-Pin , Xue Zian , Gao Yun , Sun Yi-Ping , Zhu Sanyong , Dang Yongjun , Zhao Yahui , Yuan Hai-Xin 
Published: August 2024

AbstractFerroptosis is a specific form of cell death characterized by excessive accumulation of cellular lipid peroxides. Ferroptosis is closely associated with various diseases, inhibition of which may help alleviate multi-organ injury caused by ischemia-reperfusion and enhance the anti-tumor effect by promoting the immunity of T cells. However, clinical approved drugs targeting ferroptosis process remain rare. In this study, we unexpectedly found that (R)-crizotinib, the first-generation ALK inhibitor, has potent inhibitory activity against ferroptosis across various cell lines. Moreover, its chiral molecule (S)-crizotinib, which was considered to share no common targets with (R)-crizotinib, also suppresses ferroptosis with an efficacy similar to that of (R)-crizotinib. We further demonstrated that both crizotinib enantiomers inhibit ferroptosis independently of their known targets, but through a common mechanism involving the targeting of AGPAT3-mediated synthesis of ether-linked polyunsaturated fatty acids (PE-O-PUFA), which are known to promote lipid-ROS generation and ferroptosis. In line with their activity in cell lines, (R)-crizotinib and (S)-crizotinib effectively mitigate renal ischemia-reperfusion injury in mice. Furthermore, the two compounds also inhibit lipid-ROS accumulation in CD8+ T cells in draining lymph nodes of B16-F10 subcutaneous xenograft mice, thereby promoting anti-tumor effects. Collectively, our study firstly reports a common activity shared by (R)-crizotinib and (S)-crizotinib in ferroptosis regulation. As a clinically approved drug, (R)-crizotinib has well-established pharmacokinetics and safety, which makes it a promising candidate for repurposing. Given the current lack of FDA-approved ferroptosis inhibitors, our findings suggest therapeutically repurposing (R)-crizotinib as well as its enantiomer (S)-crizotinib for treating ferroptosis-related diseases.
Genomic sequencing in newborn screening: balancing consent with the right of the asymptomatic at-risk child to be found
Authors: Knoppers Bartha Maria , Bonilha Ana Eliza , Laberge Anne-Marie , Ahmed Arzoo , Newson Ainsley J. 
Published: August 2024

Abstract
In this paper, we explore key aspects of the complex ethical and legal landscape surrounding consent in the context of incorporating genomic sequencing into existing newborn bloodspot screening programs. In particular, we consider the potential impact of genomic sequencing on the health rights of the child in relation to existing consent practices in newborn screening. We begin with an introduction to newborn screening programs and their population health goals. We then discuss public health ethics as a rationale underpinning newborn screening before turning to consent. We go on to describe seven current research projects on genomic sequencing in newborn screening and then introduce the ‘right of the asymptomatic at-risk child to be found’ as a useful concept to draw on when considering consent to newborn screening. We draw on this novel right to argue for the adoption of “appropriate consent” when it comes to certain uses of genomics in newborn screening. We contend that, for ‘virtual panels’ at least, appropriate consent proportionately balances the ongoing universality of newborn screening for important health conditions with an acknowledgement of the complex outcomes that bringing a complicated diagnostic technology into the screening domain will generate.
Machine learning assisted prediction of organic salt structure properties
Authors: Shapera Ethan P. , Bučar Dejan-Krešimir , Prasankumar Rohit P. , Heil Christoph 
Published: August 2024

AbstractWe demonstrate a machine learning-based approach which predicts the properties of crystal structures following relaxation based on the unrelaxed structure. Use of crystal graph singular values reduces the number of features required to describe a crystal by more than an order of magnitude compared to the full crystal graph representation. We construct machine learning models using the crystal graph singular value representations in order to predict the volume, enthalpy per atom, and metal versus semiconductor/insulator phase of DFT-relaxed organic salt crystals based on randomly generated unrelaxed crystal structures. Initial base models are trained to relate 89,949 randomly generated structures of salts formed by varying ratios of 1,3,5-triazine and HCl with the corresponding volumes, enthalpies per atom, and phase of the DFT-relaxed structures. We further demonstrate that the base model is able to be extended to related chemical systems (isomers, pyridine, thiophene and piperidine) with the inclusion of 2000 to 10,000 crystal structures from the additional system. After training a single model with a large number of data points, extension can be done at significantly lower cost. The constructed machine learning models can be used to rapidly screen large sets of randomly generated organic salt crystal structures and efficiently downselect the structures most likely to be experimentally realizable. The models can be used as a stand-alone crystal structure predictor, but may serve CSP efforts best as a filtering step in more sophisticated workflows.
A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathology
Authors: Gupta Priya , Galimberti Marco , Liu Yue , Beck Sarah , Wingo Aliza , Wingo Thomas , Adhikari Keyrun , Kranzler Henry R. ,   VA Million Veteran Program, Stein Murray B. , Gelernter Joel , Levey Daniel F. 
Published: August 2024

AbstractPersonality is influenced by both genetic and environmental factors and is associated with other psychiatric traits such as anxiety and depression. The ‘big five’ personality traits, which include neuroticism, extraversion, agreeableness, conscientiousness and openness, are a widely accepted and influential framework for understanding and describing human personality. Of the big five personality traits, neuroticism has most often been the focus of genetic studies and is linked to various mental illnesses, including depression, anxiety and schizophrenia. Our knowledge of the genetic architecture of the other four personality traits is more limited. Here, utilizing the Million Veteran Program cohort, we conducted a genome-wide association study in individuals of European and African ancestry. Adding other published data, we performed genome-wide association study meta-analysis for each of the five personality traits with sample sizes ranging from 237,390 to 682,688. We identified 208, 14, 3, 2 and 7 independent genome-wide significant loci associated with neuroticism, extraversion, agreeableness, conscientiousness and openness, respectively. These findings represent 62 novel loci for neuroticism, as well as the first genome-wide significant loci discovered for agreeableness. Gene-based association testing revealed 254 genes showing significant association with at least one of the five personality traits. Transcriptome-wide and proteome-wide analysis identified altered expression of genes and proteins such as CRHR1, SLC12A5, MAPT and STX4. Pathway enrichment and drug perturbation analyses identified complex biology underlying human personality traits. We also studied the inter-relationship of personality traits with 1,437 other traits in a phenome-wide genetic correlation analysis, identifying new associations. Mendelian randomization showed positive bidirectional effects between neuroticism and depression and anxiety, while a negative bidirectional effect was observed for agreeableness and these psychiatric traits. This study improves our comprehensive understanding of the genetic architecture underlying personality traits and their relationship to other complex human traits.