bluuebunny/crossref_metadata_2025_split huggingface dataset:
EGFR, KRAS, BRAF, and HER‐2 molecular status in brain metastases from 77 NSCLC patients
Authors: Villalva Claire , Duranton‐Tanneur Valérie , Guilloteau Karline , Burel‐Vandenbos Fanny , Wager Michel , Doyen Jérôme , Levillain Pierre Marie , Fontaine Denys , Blons Hélène , Pedeutour Florence , Karayan‐Tapon Lucie 
Published: June 2013

AbstractThe aim of this study was to determine the frequency of EGFR, KRAS, BRAF, and HER‐2 mutations in brain metastases from non‐small cell lung carcinomas (BM‐NSCLC). A total of 77 samples of BM‐NSCLC were included and 19 samples of BM from breast, kidney, and colorectal tumors were also studied as controls. These samples were collected from patients followed between 2008 and 2011 at Poitiers and Nice University Hospitals in France. The frequencies of EGFR, KRAS, BRAF, and HER‐2 mutations in BM‐NSCLC were 2.6, 38.5, 0, and 0% respectively. The incidence of KRAS mutation was significantly higher in female and younger patients (P < 0.05). No mutations of the four genes were found in BM from breast or kidney. However, among six BM from colorectal tumors, we identified KRAS mutations in three cases and BRAF mutations in two other cases. This study is the largest analysis on genetic alterations in BM‐NSCLC performed to date. Our results suggest a low frequency of EGFR mutations in BM‐NSCLC whereas KRAS mutations are as frequent in BM‐NSCLC as in primitive NSCLC. These results raise the question of the variability of the brain metastatic potential of NSCLC cells in relation to the mutation pattern.
The current state of medical simulation in interventional cardiology: A clinical document from the Society for Cardiovascular Angiography and Intervention's (SCAI) Simulation Committee
Authors: Green Sandy M. , Klein Andrew J. , Pancholy Samir , Rao Sunil V. , Steinberg Daniel , Lipner Rebecca , Marshall Jeffery , Messenger John C. 
Published: June 2013

ObjectivesTo assess the current use and application of simulators in interventional cardiology.BackgroundDespite a paucity of data on the efficacy of simulation in medicine, cardiovascular simulation training is now a mandated part of cardiovascular fellowship training. Additionally, simulators have been endorsed by the Food and Drug Administration as a way to teach physicians new and novel procedures. We sought to establish the current use of simulators in cardiovascular medicine.MethodsA systematic review was done of available training programs, and currently existing data regarding simulation training. A panel of experts was convened to review this data and provide recommendations as how simulation should be used in the field of interventional cardiology.ResultsThis document provides a comprehensive review of the current state of simulation and how we as a society must formulate well validated studies to more closely examine and explore how this technology can be further studied and validated.ConclusionsSimulation will likely take on a larger role in cardiovascular training and maintenance of certification, but at the current time lacks a large body of evidence for its use. © 2013 Wiley Periodicals, Inc.
Dual Effect of Low‐Dosage Poly(Ethylene Oxides) on Methane Hydrate Formation
Authors: Sina M. , Nazari K. , Mohammad‐Taheri M. , Moradi M. R. 
Published: June 2013

AbstractTime‐dependent isochoric formation of methane hydrate was investigated in the presence of low‐dose poly(ethylene oxides) (PEOs). The effect of different molecular weights of PEO on methane hydrate nucleation time and storage capacity was studied and compared. Kinetic measurements revealed a dual effect of PEO, including inhibition and stabilization effects, on methane hydrate formation. The nature and type of the effect arises from the difference in molecular weights and concentration ranges of PEOs. These parameters directly affect the nucleation time and storage capacity of methane hydrate. Generally, in comparison with pure water, PEO improved the storage capacity of methane hydrate. PEO (1000 kD) at a concentration of 0.5 wt % exhibits a significant kinetic inhibitory performance. However, it was an efficient low‐dosage hydrate stabilizer at a concentration of 0.25 wt %, along with producing gas‐rich methane hydrate suitable for gas fuel storage and transportation.
Electrolyte Convection in Flooded Lead‐Acid Batteries – Testing of Passive Mixing Elements in the Vehicle
Authors: Ebner Ellen , Metge Ingo , Keil Sabrina Nadine , Börger Alexander 
Published: June 2013

AbstractNeue Fahrzeugtechnologien mit Mikro‐Hybrid‐Konzepten, die über Start‐Stopp‐Funktion und regeneratives Bremsen verfügen, stellen erhöhte Anforderungen an die Blei‐Säure‐Starterbatterie. Die sich während der Start‐Stopp‐Zyklen im Fahrzeug bei Batterien mit flüssigen Elektrolyten einstellende inhomogene Säuredichteverteilung führt zu einer inhomogenen Stromverteilung. Passive Mischelemente zeigen hohe Wirksamkeit beim Ausgleich von Säuredichteunterschieden innerhalb des Elektrolyten. Zur Beurteilung der Wirksamkeit von Mischelementen im Fahrzeugbetrieb wurden weiterentwickelte Blei‐Säure‐Nassbatterien in Fahrzeugen gealtert. Dabei wurden Innenwiderstandsverläufe und Ladezustandsänderungen verfolgt. Die Untersuchung zeigte, dass sich passive Mischelemente für den Einsatz in Fahrzeugen mit Start‐Stopp‐Funktion eignen.
Wie wird unser Trinkwasser überwacht?
Authors: Sacher Frank 
Published: June 2013

AbstractDie Überwachung unseres Trinkwassers wird immer auch durch neue wissenschaftliche Erkenntnisse und Fortschritte beim verfügbaren analytischen Instrumentarium beeinflusst. Die moderne Trinkwasserüberwachung macht sich diese Entwicklungen zu Nutze, um jederzeit eine hohe Wasserqualität sicherstellen zu können. Trends in modernen Wasserlaboratorien sind eine zunehmende Automatisierung, die Einführung hochwertiger Messgeräte und neuer Analyseverfahren für chemische und biologische Parameter, der Einzug von Effekt‐bezogenen Analyseverfahren (Biotests) sowie von Analysesystemen zur Online‐Überwachung der Trinkwasserqualität und zur frühzeitigen Erkennung von Kontaminationen und Störungen im Aufbereitungsprozess.
Imaging Intracellular Zinc by Using a Glyoxal Bis(4‐methyl‐4‐phenyl‐3‐thiosemicarbazone) Ligand
Authors: Palanimuthu Duraippandi , Shinde Sridevi Vijay , Dayal Disha , Somasundaram Kumaravel , Samuelson Ashoka G. 
Published: June 2013

AbstractThe ligand glyoxal bis(4‐methyl‐4‐phenyl‐3‐thiosemicarbazone) (GTSCH2) is shown to be a selective fluorescence “turn‐on” sensor for zinc ions (Zn2+). This sensor is easy to synthesize, exhibits excellent sensitivity and selectivity towards Zn2+ over other physiologically relevant cations, and has sub‐nanomolar binding affinity. It displays maximum fluorescence response to Zn2+ when the metal/ligand ratio is 1:1 and displays stable fluorescence over a broad pH range. The potential of GTSCH2 to image Zn2+ inside the cell was demonstrated in MCF‐7 cells (human breast cancer cell line) by using flow cytometry and confocal fluorescence microscopy. Cell viability studies reveal that the probe is biocompatible and suitable for cellular applications.
Poor Catch‐up Growth in Late Adolescent Boys with Eating Disorders, Weight Loss and Stunting of Growth
Authors: Swenne Ingemar 
Published: June 2013

AbstractObjectiveThe study aims to investigate the catch‐up growth of boys presenting with an eating disorder (ED) and a stunting of growth.MethodWeight gain and growth of 46 boys with ED were followed up for 1–3 years.ResultsA total of 13 boys who had not started their pubertal growth spurt at presentation started catch‐up growth immediately following nutritional rehabilitation and weight gain. After 3 years, they had returned to their premorbid growth curve. Thirty‐three boys who had started their pubertal growth spurt prior to presentation never caught up in height but continued to catch down despite weight gain. After 3 years, they had lost 0.64 ± 0.55 height standard deviation scores corresponding to approximately 4.5 cm of potential height.ConclusionsIn prepubertal boys with EDs, catch‐up growth is possible. Pubertal boys are at a disadvantage in that catch‐up growth may not occur despite weight gain. Copyright © 2013 John Wiley & Sons, Ltd and Eating Disorders Association.
A laboratory and in situ postexposure feeding assay with a freshwater snail
Authors: Correia Vânia , Ribeiro Rui , Moreira-Santos Matilde 
Published: June 2013

Abstract

Contaminant-driven feeding inhibition has direct and immediate consequences at higher levels of biological organization, by depressing the population consumption and thus hampering ecosystem functioning (e.g., grazing, organic matter decomposition). The present study aimed at developing a short-term laboratory and in situ assay based on the postexposure feeding of the freshwater snail Theodoxus fluviatilis. A method to precisely quantify feeding rates was first developed, consisting of a 3-h feeding period, in darkness, on 150 defrosted nauplii of the brine shrimp Artemia franciscana. Postexposure feeding after a 48-h exposure to cadmium was approximately as sensitive as survival, with the median effective concentration (EC50) and median lethal concentration (LC50) being 85 µg/L and 102 µg/L, respectively, and the 20% effective concentration (EC20) and 20% lethal concentration (LC20) being 41 µg/L and 77 µg/L, respectively. Together, both effects at the LC20 reduced population consumption by 56%. In situ experiments at reference sites covering broad ranges of current velocity, hardness, conductivity, sediment organic matter content, and sediment particle size distribution revealed the influence of these abiotic conditions on postexposure feeding, in the absence of contamination, to be negligible. The effectiveness of the in situ assay was evaluated at 5 sites contaminated with acid mine drainage. Surviving organisms at the single partially lethal site (37% mortality) presented a 54% feeding inhibition relative to the reference, whereas the population consumption would be inhibited by 71%, confirming the integration of survival and feeding to be pertinent for estimating contaminant effects at higher levels of biological organization. Environ Toxicol Chem 2013;32:2144–2152. © 2013 SETAC
Phototoxicity of TiO2 nanoparticles to zebrafish (Danio rerio) is dependent on life stage
Authors: Ma Hongbo , Diamond Stephen A. 
Published: June 2013

Abstract

Zebrafish embryos have been used increasingly to evaluate nanomaterial toxicity. The present study compared phototoxicity of TiO2 nanoparticles with zebrafish at 4 life stages (embryos, yolk-sac larvae, free-swimming larvae, and juvenile) under simulated sunlight using the 96-h standard toxicity assay. Yolk-sac larvae were found to be the most sensitive to TiO2 phototoxicity, suggesting that the widely used zebrafish embryo test may not fully or accurately predict hazard and risk of these nanoparticles to small fish. Environ Toxicol Chem 2013;32:2139–2143. © 2013 SETAC
Coseismic offsets due to the 11 April 2012 Indian Ocean earthquakes (Mw 8.6 and 8.2) derived from GPS measurements
Authors: Yadav Rajeev Kumar , Kundu Bhaskar , Gahalaut Kalpna , Catherine Joshi , Gahalaut Vineet K. , Ambikapthy A. , Naidu M. S. 
Published: June 2013

AbstractThe 11 April 2012 earthquake (Mw 8.6) in the Indian Ocean, about 100 km west off the Sumatra subduction zone, is the largest intraplate strike‐slip earthquake in the known history. Two hours later, it triggered another great earthquake of Mw 8.2 in its vicinity. The earthquakes reflect the internal deformation of the diffused plate boundary between India and Australia caused by the differential plate motion between them. The slip occurred on conjugate planes, and the presence of some of them has been reported from the swath bathymetry and satellite magnetic anomalies. We estimate coseismic offsets due to these earthquakes at continuous GPS sites in the Andaman‐Nicobar region and at other International GNSS Service (IGS) sites around the earthquakes source region. The sites on the Andaman Islands, which are about 900–1200 km to the north of the earthquake epicenters, experienced predominantly southward coseismic offset of up to 3 cm. The nearest site, Campbell Bay, on Great Nicobar Island, about 500 km to the north of the earthquake, documented an ESE offset of about 4 cm. The coseismic offsets are consistent with the finite‐fault slip models derived from back projection of the seismic waves recorded by the global networks.
High‐precision location and yield of North Korea's 2013 nuclear test
Authors: Zhang Miao , Wen Lianxing 
Published: June 2013

AbstractUsing North Korea's 2009 nuclear test as reference and satellite imagery, we show that the location and yield of North Korea's 2013 nuclear test can be quickly and accurately determined based on seismic data. North Korea's 2013 nuclear test site is pinpointed by deriving relative location of North Korea's 2009 and 2013 nuclear tests and using the previously determined location of the 2009 nuclear test, while its yield is estimated based on the relative amplitude ratios of the Lg waves recorded for both events, the previously determined Lg‐magnitude of 2009 nuclear test and burial depth inferred from satellite imagery. North Korea's 2013 test site is determined to be located at (41°17′26.88″N, 129°4′34.68″E), about 345 m south and 453 m west of its 2009 nuclear test site, with a geographic precision of 94 m. Its yield is estimated to be 12.2 ± 3.8 kt.
Presence of human papillomaviruses and p16 expression in hypopharyngeal cancer
Authors: Wendt Malin , Romanitan Mircea , Näsman Anders , Dalianis Tina , Hammarstedt Lalle , Marklund Linda , Ramqvist Torbjörn , Munck–Wikland Eva 
Published: June 2013

AbstractBackgroundPatients with hypopharyngeal cancer have a 5‐year survival of only 15% to 30%. Human papillomavirus (HPV) is a risk factor and a favorable prognostic factor for oropharyngeal carcinoma and p16 has been suggested as a surrogate marker for HPV‐induced cancer. However, few studies have been performed on HPV and p16 in hypopharyngeal cancer.MethodsOne hundred nine pretreatment hypopharyngeal cancer biopsies were analyzed for presence of HPV and p16 overexpression, and the results were correlated to patient survival.ResultsOf 109 tumors, 7 were HPV‐positive (4 HPV16) and 18 overexpressed p16. There was some correlation between survival and HPV status, but not with regard to p16 expression. Notably, all patients with HPV16‐positive tumors, also overexpressing p16, lived tumor free for more than 3 years.ConclusionOur results indicate that HPV‐induced hypopharyngeal cancer is rare and that p16 is not a suitable biomarker for presence of HPV in this tumor type. © 2013 Wiley Periodicals, Inc. Head Neck 36: 107–112, 2014
Primary orbital eosinophilic angiocentric fibrosis with intranasal extension
Authors: Karligkiotis Apostolos , Volpi Luca , Ferreli Fabio , Cerati Michele , Kagkelari Effrosyni , Meloni Francesco , Castelnuovo Paolo 
Published: June 2013

AbstractBackgroundEosinophilic angiocentric fibrosis is a chronic, idiopathic disorder that usually involves the upper respiratory tract and features progressive submucosal perivascular fibrosis of unknown etiology. To our knowledge, only 5 cases of eosinophilic angiocentric fibrosis with primary orbital involvement have been reported.Methods and ResultsWe report the case of a 46‐year‐old man with right proptosis and lateral globe displacement caused by a primary eosinophilic angiocentric fibrosis extending from the orbit into the anterior ethmoid. The nasal extension of the lesion helped in establishing the correct diagnosis.ConclusionPhysicians involved in the treatment of orbital pathologies should be familiar with this entity, because it may manifest as an intraorbital mass growing primarily or secondly into the orbit. The clinical manifestations of eosinophilic angiocentric fibrosis with orbital involvement often mimic other more common ophthalmological diseases. Biopsies are necessary for diagnosis and treatment planning, although cures are usually of palliative effect. © 2013 Wiley Periodicals, Inc. Head Neck 36: E8–E11, 2014
Pretreatment circulating monocyte count associated with poor prognosis in patients with oral cavity cancer
Authors: Tsai Yu‐Duan , Wang Chao‐Ping , Chen Chih‐Yu , Lin Li‐Wen , Hwang Tzer‐Zen , Lu Li‐Fen , Hsu Hsia‐Fen , Chung Fu‐Mei , Lee Yau‐Jiunn , Houng Jer‐Yiing 
Published: June 2013

AbstractBackgroundThe purpose of this study was to investigate whether the pretreatment total and differential leukocyte counts can predict the prognosis of patients with oral cavity cancer.MethodsIn a retrospective analysis of patients treated between 2004 and 2011, medical records of 202 patients with oral cavity cancer were evaluated.ResultsPatients with oral cavity cancer, the peripheral total white blood cell (WBC) count, monocyte, and neutrophil counts and neutrophil lymphocyte ratio increased with the advancement of clinical stage. In contrast, the lymphocyte count decreased. Further, total WBC, monocyte, and neutrophil counts were increased in those with pathologic stage T4 and poor tumor differentiation, and the monocyte count was also increased in those with lymph node metastasis. Moreover, the pretreatment circulating monocyte count was an independent prognostic factor for cancer‐specific survival.ConclusionA higher pretreatment circulating monocyte count can be considered as a useful prognostic marker in patients with oral cavity cancer. © 2014 Wiley Periodicals, Inc. Head Neck 36: 947–953, 2014
Estimation of submarine groundwater discharge in the Il‐Gwang watershed using water budget analysis and 222Rn mass balance
Authors: Gwak Yong‐Seok , Kim Sang‐Hyun , Lee Yong‐Woo , Khim Boo‐Keun , Hamm Se‐Yeong , Kim Sung‐Wok 
Published: June 2013

AbstractSubmarine groundwater discharges (SGD) were investigated in a marine watershed in south‐eastern Korea using water budget analysis and a 222Rn mass balance model. Multi‐layered TOPMODEL added hydrological assumption was used to estimate groundwater components in the water budget analysis. Field observations of soil moisture, rainfall, runoff and groundwater fluctuations were used for calibration and validation of the hydrologic model. Based on observed hydrological data and terrain analyses, parameters for the hydrologic model were delineated and used to describe several hydrologic responses in the watershed. SGD estimations by 222Rn mass balance method were also performed at Il‐Gwang bay in July, 2010, and May, June, July and Nov. 2011. The estimated groundwater through hydrologic modeling and water balance analysis was 1.3x106 m3/year, which rapidly increased during typhoon season due to heavy rainfall and permeable geologic structure. The estimated groundwater was approximately 3.7–27.1% of SGD as evaluated by 222Rn mass balance method ranges 3.44 and 17.45 m3m−2year−1. Even though SGD is predominantly influenced by tide fluctuation, the head gradient (difference) from hydrologic processes associated with heavy rainfalls can also have extra significant influences. Comprehensive understanding of SGD evaluation can be improved through a simultaneous application of both these approaches. Copyright © 2013 John Wiley & Sons, Ltd.
Energization of O+ ions in the Earth's inner magnetosphere and the effects on ring current buildup: A review of previous observations and possible mechanisms
Authors: Keika Kunihiro , Kistler Lynn M. , Brandt Pontus C. 
Published: June 2013

AbstractIn situ observations and modeling work have confirmed that singly charged oxygen ions, O+, which are of Earth's ionospheric origin, are heated/accelerated up to >100 keV in the magnetosphere. The energetic O+ population makes a significant contribution to the plasma pressure in the Earth's inner magnetosphere during magnetic storms, although under quiet conditions, H+ dominates the plasma pressure. The pressure enhancements, which we term energization, are caused by adiabatic heating through earthward transport of source population in the plasma sheet, local acceleration in the inner magnetosphere and near‐Earth plasma sheet, and enhanced ion supply from the topside ionosphere. The key issues regarding stronger O+ energization than H+ are nonadiabatic local acceleration, responsible for increase in O+ temperature, and more significant O+ supply than H+, responsible for the increase in O+ density. Although several acceleration mechanisms and O+ supply processes have been proposed, it remains an open question what mechanism(s)/process(es) play the dominant role in stronger O+ energization. This review paper summarizes important previous spacecraft observations, introduces the proposed mechanisms/processes that generate O+‐rich energetic plasma population, and outlines possible scenarios of O+ pressure abundance in the Earth's inner magnetosphere.
Enhancement in a brain glioma model: A comparison of half‐dose gadobenate dimeglumine versus full‐dose gadopentetate dimeglumine at 1.5 and 3 T
Authors: Morelli John N. , Gerdes Clint M. , Zhang Wei , Williams Jonathon M. , Saettele Megan R. , Ai Fei 
Published: June 2013

PurposeTo examine dose reduction comparing enhancement with full‐dose gadopentetate dimeglumine (0.1 mmol/kg) to half‐dose gadobenate dimeglumine in a rat brain glioma model.Materials and MethodsIntra‐axial parenchymal brain tumors were implanted in 17 experimental animals. The 13 surviving animals were imaged at 1.5 or 3 T. Either gadopentetate dimeglumine or gadobenate dimeglumine was injected in random order on consecutive days. Tumor signal‐to‐noise ratio (SNR), contrast‐to‐noise ratio (CNR), and contrast enhancement (CE) for each agent were obtained with region of interest analyses and compared. Lesions were confirmed histopathologically.ResultsStatistically significantly lower SNR, CNR, and CE parameters were found at both 1.5 and 3 T with half‐dose gadobenate dimeglumine relative to full‐dose gadopentetate dimeglumine (P < 0.05). SNR on average at 3 T was 70.0 ± 14.4 for gadopentetate dimeglumine and 57.0 0 ± 4.8 for gadobenate dimeglumine (P < 0.02).ConclusionImproved r1 relaxivity with gadobenate dimeglumine does not produce adequate half‐dose contrast‐enhancement relative to full‐dose gadopentetate dimeglumine. J. Magn. Reson. Imaging 2013;38:306–311. © 2012 Wiley Periodicals, Inc.
Use of 99mTc 2‐methoxyisobutyl isonitrile in minimally invasive radioguided surgery in patients with primary hyperparathyroidism: A narrative review of the current literature
Authors: Denmeade Kristie A. , Constable Chris , Reed Warren M. 
Published: June 2013

AbstractThe use of technetium‐99m 2‐methoxyisobutyl isonitrile (99mTc MIBI) for assistance in minimally invasive radioguided surgery (MIRS) is growing in popularity as a safe, effective, and proficient technique used for parathyroidectomy in primary hyperparathyroidism (PHPT) treatment. Previously, the preferred treatment for PHPT was bilateral neck exploration (BNE), a very invasive, costly, and lengthy procedure. However, as a large majority (80–85% of cases of PHPT) are attributed to a single parathyroid adenoma (PA), a simpler more direct technique such as MIRS is a far better option. The following article is an exploration of the current literature concerning varied protocols utilizing 99mTc MIBI for assistance in MIRS for patients undergoing treatment of PHPT. This technique boasts many advantageous outcomes for patients suffering from PHPT. These include a reduction in cost, operating time, and patient recovery; less evidence of post‐surgical hypocalcaemia, less pain, and complications; superior cosmetic results; same‐day discharge; and the possibility of local anaesthesia which is particularly beneficial in elderly patients. Better outcomes for patients with deep or ectopic PAs, reduced intra‐operative complications, and improved cosmetic outcomes for patients who have previously undergone thyroid and/or parathyroid surgery are also advantageous. Of the literature reviewed it was also found that no patients suffered any major surgical complications such as laryngeal nerve palsy or permanent hypoparathyroidism using 99mTc MIBI for assistance in MIRS.