bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Cu‐MOF‐decorated ammonium polyphosphate for epoxy resins with reduced smoke release and enhanced char layer
Authors: Chai Juan , Hou Yaxin , Zhang Yanhui , Xia Yan , Ran Shiya , Wang Shengyan , Chen Nianfu , Guo Zhenghong , Li Juan , Fang Zhengping 
Published: June 2024

AbstractInspired by the significant catalytic charring effect of metal–organic frameworks (MOFs), Cu‐MOF decorated ammonium polyphosphate (APP@Cu‐MOF) was prepared by coupling agents to improve the fire safety of epoxy resin (EP). After adding 9 wt% APP@Cu‐MOF, the fire performance of EP is significantly improved with limiting oxide index (LOI) value of 29.4 and UL‐94 V‐0 rating. The peak heat release rate (PHRR), total smoke production (TSP), CO production, and CO2 production of EP composite samples decreased by 34.6%, 54.7%, 24.6% and 30.0%, respectively. It is proposed that the synergistic effect among Cu‐MOF and APP promoted the char formation of EP. The dense carbon layers formed a barrier that prevented the transfer of heat and inhibited the release of toxic gases, thus acting as a flame retardant. This work provides a new strategy to develop a high‐efficient MOF‐decorated flame retardant with smoke inhibition, toxicity reduction, and catalytic carbonization effect.
Preparation and characterization of high‐solid carboxylate/sulfonate waterborne polyurethane and its application in novel water‐based superfine fiber synthetic material
Authors: Qiao Pengfei , Zhang Feifei , Lu Aide , Liu Jie , Jin Liqiang , Wang Yulu 
Published: June 2024

AbstractWith isophorone diisocyanate and polytetrahydrofuran as basic raw materials, dimethylolpropionic acid and 2,3‐dihydroxypropanesulfonic acid triethylamine salt (DHPSTEA) as chain extension agents, trimethylolpropane as crosslinking agent, N, N‐dimethylethanolamine as neutralizer, the high‐solid carboxylate/sulfonate waterborne polyurethane (SC‐HWPU) was synthesized. The effect of COO−/SO3− molar ratio on the properties of SC‐HWPU was studied. Fourier transform infrared and x‐ray photoelectron spectroscopy results demonstrated that the SC‐HWPU molecular chain contained carboxylate and sulfonate groups. The results of thermogravimetric analysis, dynamic mechanical analysis, and mechanical properties of SC‐HWPU film indicated that higher DHPSTEA content was favorable for the thermostability and mechanical properties when the total dosage of hydrophilic groups was invariable. When the mole ratio of COO−/SO3− is 8:2, the solid content of the prepared SC‐HWPU3 emulsion can reach to 51.6%, which has excellent storage stability and alkali resistance stability. Subsequently, the application of SC‐HWPU emulsion on the fixed‐island type polyamide/polyethylene terephthalate copolymer superfine fiber non‐woven fabric single‐coating process was analyzed, and the water‐base superfine fiber non‐woven fabric was prepared. Scanning electron microscopy showed that there was still a large amount of SC‐HWPU filled in the superfine fiber gap after alkali‐decrement, indicating that SC‐HWPU has excellent alkali resistance.
Regulation of hsa_circ_0112136 by m6A demethylase FTO can enhance the malignancy of gastric cancer via the regulation of the PI3K/AKT/mTOR pathway
Authors: Liu Jia , Fang Xiangming 
Published: June 2024

AbstractA growing body of research highlights the role that N6‐methyladenosine (m6A) modification and circular RNAs (circRNAs) play in gastric cancer (GC) cases. However, studies elucidating the function and mechanism of the recently discovered circRNA hsa_circ_0112136 in GC are limited. This study aimed to examine the pathophysiology of GC progression due to fat mass and obesity‐associated protein (FTO)‐mediated N6‐methyladenosine (m6A) modification of hsa_circ_0112136. The hsa_circ_0112136 and FTO levels in the GC samples were analyzed using qRT‐PCR. The Transwell invasion assay, wound healing assay, and CCK8 assays were employed to assess alterations in GC cell invasiveness, migration, and viability due to the aberrant regulation of hsa_circ_0112136 and FTO. Phosphorylated PI3K, AKT, and mTOR (the key proteins of the PI3K/AKT/mTOR pathway) were detected via western blotting after hsa_circ_0112136 suppression. A tumor transplantation mouse model was constructed to evaluate the suppression of hsa_circ_0112136's function in vivo. The correlation among hsa_circ_0112136 and FTO was identified using the MeRIP assay.Levels of hsa_circ_0112136 and FTO were evidently elevated in GC samples. Suppression of has_circ_0112136 reduced the viability, migration, and invasive ability of GC cells in vitro, as well as delayed tumor growth in vivo via suppression of the activation of the PI3K/AKT/mTOR pathway. FTO decreased hsa_circ_0112136 m6A levels and enhanced hsa_circ_0112136 expression. Furthermore, FTO upregulation enhanced GC cell invasion, migration, and survival, which was reversed by hsa_circ_0112136 suppression.Our study proposes that hsa_circ_0112136 functions as a tumor promoter, facilitating the malignant progression of GC through m6A modification (suppressed by FTO) and activating the PI3K/AKT/mTOR pathway. This suggests that targeting FTO‐m6A‐hsa_circ_0112136‐PI3K/AKT/mTOR may be a novel approach for GC intervention.
Auswirkungen des Nutzungsverhaltens auf den Energieverbrauch im Mietwohnungsbau
Authors: Lehmann Bettina , Schirmer Matthias 
Published: June 2024

AbstractDiese Studie untersucht anhand von realen Messdaten der Abrechnungsjahre 2019 bis 2023 den Energieverbrauch von 26 gas‐ und fernwärmebeheizten Mietwohngebäuden mit insgesamt 873 Wohneinheiten. Mittels Gegenüberstellung von Energiebedarfs‐ und Energieverbrauchsausweisen wird die Diskrepanz zwischen prognostizierten und gemessenen Endenergieverbräuchen dargestellt, welche das vermutete Potenzial des Nutzungsverhaltens widerspiegelt. Sowohl in unsanierten als auch sanierten Wohngebäuden wird eine teils erhebliche negative Leistungslücke festgestellt. Die Verbrauchskennwerte des Jahres 2022 vergrößern diesen Energy Performance Gap zusätzlich. Mit dieser Analyse soll die Bedeutung einer ganzheitlichen Betrachtung von Bedarfs‐ und Verbrauchskennwerten für zukünftige Planungen und Prognosen hervorgehoben werden.
Grundlagen zur brandschutztechnischen Anwendbarkeit von begrünten Fassaden an mehrgeschossigen Gebäuden
Authors: Engel Thomas , Winter Stefan 
Published: June 2024

AbstractBegrünte Fassaden liegen im Trend. Die Brandausbreitung entlang der Fassade stellt grundsätzlich weltweit eines der kritischsten Brandszenarien dar, und Pflanzen sind zusätzliche brennbare Materialien. Der Einfluss begrünter Fassaden auf die Brandweiterleitung entlang der Fassade ist folglich nicht zu vernachlässigen. Allerdings steht nur wenig Forschung zu diesem Thema zur Verfügung. Dies soll das Forschungsvorhaben FireSafeGreen ändern. Haupteinflussfaktor auf das Brandverhalten von Pflanzen ist der Feuchtigkeitsgehalt. Die Pflanzenart selbst spielt eine untergeordnete Rolle in Bezug auf das Brandverhalten. Eine Kombination aus Holz‐ und begrünter Fassade führt unter Berücksichtigung einiger Randbedingungen nicht zu einer Entzündung der dahinterliegenden Holzfassade. Grundsätzlich sind die angemessene Pflege und Wartung die maßgebenden Faktoren für brandsichere begrünte Fassaden.
Imaging modalities for characterising T1 renal tumours: A systematic review and meta‐analysis of diagnostic accuracy
Authors: Warren Hannah , Fanshawe Jack B. , Mok Valerie , Iyer Priyanka , Chan Vinson Wai‐Shun , Hesketh Richard , Zimmermann Eleanor , Kasivisvanathan Veeru , Emberton Mark , Tran Maxine G. B. , Gurusamy Kurinchi 
Published: June 2024

AbstractObjectivesInternational guidelines recommend resection of suspected localised renal cell carcinoma (RCC), with surgical series showing benign pathology in 30%. Non‐invasive diagnostic tests to differentiate benign from malignant tumours are an unmet need. Our objective was to determine diagnostic accuracy of imaging modalities for detecting cancer in T1 renal tumours.MethodsA systematic review was performed for reports of diagnostic accuracy of any imaging test compared to a reference standard of histopathology for T1 renal masses, from inception until January 2023. Twenty‐seven publications (including 2277 tumours in 2044 participants) were included in the systematic review, and nine in the meta‐analysis.ResultsForest plots of sensitivity and specificity were produced for CT (seven records, 1118 participants), contrast‐enhanced ultrasound (seven records, 197 participants), [99mTc]Tc‐sestamibi SPECT/CT (five records, 263 participants), MRI (three records, 220 participants), [18F]FDG PET (four records, 43 participants), [68Ga]Ga‐PSMA‐11 PET (one record, 27 participants) and [111In]In‐girentuximab SPECT/CT (one record, eight participants). Meta‐analysis returned summary estimates of sensitivity and specificity for [99mTc]Tc‐sestamibi SPECT/CT of 88.6% (95% CI 82.7%–92.6%) and 77.0% (95% CI 63.0%–86.9%) and for [18F]FDG PET 53.5% (95% CI 1.6%–98.8%) and 62.5% (95% CI 14.0%–94.5%), respectively. A comparison hierarchical summary receiver operating characteristic (HSROC) model did not converge. Meta‐analysis was not performed for other imaging due to different thresholds for test positivity.ConclusionThe optimal imaging strategy for T1 renal masses is not clear. [99mTc]Tc‐sestamibi SPECT/CT is an emerging tool, but further studies are required to inform its role in clinical practice. The field would benefit from standardisation of diagnostic thresholds for CT, MRI and contrast‐enhanced ultrasound to facilitate future meta‐analyses.
An industrial perspective on metabolic responses of Penicillium chrysogenum to periodic dissolved oxygen feast‐famine cycles in a scale‐down system
Authors: Wang Xueting , Yang Qi , Haringa Cees , Wang Zejian , Chu Ju , Zhuang Yingping , Wang Guan 
Published: June 2024

AbstractWhile traveling through different zones in large‐scale bioreactors, microbes are most likely subjected to fluctuating dissolved oxygen (DO) conditions at the timescales of global circulation time. In this study, to mimic industrial‐scale spatial DO gradients, we present a scale‐down setup based on dynamic feast/famine regime (150 s) that leads to repetitive cycles with rapid changes in DO availability in glucose‐limited chemostat cultures of Penicillium chrysogenum. Such DO feast/famine regime induced a stable and repetitive pattern with a reproducible metabolic response in time, and the dynamic response of intracellular metabolites featured specific differences in terms of both coverage and magnitude in comparison to other dynamic conditions, for example, substrate feast/famine cycles. Remarkably, intracellular sugar polyols were considerably increased as the hallmark metabolites along with a dynamic and higher redox state (NADH/NAD+) of the cytosol. Despite the increased availability of NADPH for penicillin production under the oscillatory DO conditions, this positive effect may be counteracted by the decreased ATP supply. Moreover, it is interesting to note that not only the penicillin productivity was reduced under such oscillating DO conditions, but also that of the unrecyclable byproduct ortho‐hydroxyphenyl acetic acid and degeneration of penicillin productivity. Furthermore, dynamic flux profiles showed the most pronounced variations in central carbon metabolism, amino acid (AA) metabolism, energy metabolism and fatty acid metabolism upon the DO oscillation. Taken together, the metabolic responses of P. chrysogenum to DO gradients reported here are important for elucidating metabolic regulation mechanisms, improving bioreactor design and scale‐up procedures as well as for constructing robust cell strains to cope with heterogenous industrial culture conditions.
Construction of a new lifelong education system based on vector analysis algorithms for information age services
Authors: Zhang Yongfang , Ye Hui , Chen Haijun 
Published: June 2024

AbstractIn today's rapidly evolving society, the establishment of a learning society is paramount. The lifelong education system (LLES) plays a crucial role in enriching individuals' intellectual and emotional landscapes, fostering continuous growth, and instilling the habit of lifelong learning. However, traditional lifelong education systems often have limitations regarding accessibility, openness, and resource‐sharing, limiting opportunities for lifelong learning and dampening enthusiasm for it. To address these limitations, it is hypothesized that integrating information technology, specifically vector analysis algorithms, into lifelong education systems can revolutionize the learning experience (LE). By leveraging the power of the internet and advanced algorithms, it is expected that a new LLES can offer a superior online learning environment, enriched resources, and intelligent data analysis capabilities, thereby facilitating more effective lifelong learning. The methodology involves the development and implementation of an information age service based on vector analysis algorithms within the lifelong education framework. This study aims to provide learners with enhanced access to high‐quality online learning resources while offering intelligent data analysis to optimize learning pathways. With the continuous development of Internet technology, information technology has been applied to various fields. Information age services (IAS) based on vector analysis algorithms (VAAs) will be combined with LLES. Technology will be utilized to the maximum to provide lifelong learners with a high‐quality online learning environment, online learning resources, and intelligent data analysis to help learners better conduct lifelong learning. Experimental results comparing the new LLES with traditional approaches demonstrated significant improvements. The new system enhanced the matching of teaching materials by 31.8%, offered a wider and more convenient learning path, and provided access to a greater variety of teaching resources. Moreover, learners using the new system exhibited an average learning increase of 7%. The integration of IAS based on VAAs into lifelong education represents a substantial advancement. This innovative approach offers superior teaching resources, educational methods, and learning opportunities, empowering individuals to embrace and sustain lifelong learning journeys more effectively in the digital age.
Research and application of digital electrical substation virtual engineering education system
Authors: Li Bai‐Lin , Ma Yun‐Fan , Zhang Chao , Chu Fan‐Wu , Chen Yu‐Rui , Quan Peng 
Published: June 2024

AbstractThe education and training of electrical substations play an essential role for college students and engineers majoring in electrical engineering. However, to ensure the substation's safety production and equipment operation, it is difficult for personnel from external units to enter the site for learning. To overcome these limitations, this paper proposes a virtual interactive training technology method to author an interactive virtual maintenance education system (VMES) for electrical substations. The system aims to build a visual training and education platform for virtual substations to help learners master the station's equipment, operation, maintenance, evaluation, and other processes. Firstly, the system establishes a component‐level virtual interaction element to encapsulate an electrical substation virtual maintenance model that dynamically responds to user operations. The equipment structure and system environment are visually modeled using engineering modeling software. Secondly, a virtual interactive training system is created with the functions of 3D disassembly training, fault tree reliability evaluation, and AHP‐FCE maintenance assessment. Finally, through four operating systems, we evaluate the compatibility of the VMES, and we recruit learners to evaluate and discuss emerging and common educational models. The practical application results prove that the system can significantly improve students' learning efficiency and interest. Meanwhile, due to the increased number of interactive operations in VMES, participants can proficiently master the composition and working principles of equipment in substations, and cognitive load can be reduced.
Tracing the evolving dynamics and research hotspots in the kidney neoplasm and nephron sparing surgery field from the past to the new era
Authors: Yao Yuntao , Liu Yifan , Yang Tianyue , Lu Bingnan , Yang Xinyue , Zhang Haoyu , Zhao Zihui , Huang Runzhi , Zhou Wang , Pan Xiuwu , Cui Xingang 
Published: June 2024

AbstractBackgroundWith increasing detection of small renal masses and accumulating evidence that nephron sparing surgery (NSS) could achieve oncological equivalence and functional superiority compared with radical nephrectomy (RN), NSS has become first‐line therapy for some patients with localized renal masses.ObjectiveThis study aims to review the publications in the kidney neoplasm and NSS field, exploring the research hotspots.MethodKidney neoplasm and NSS related publications before July 3th 2023 were obtained from the Web of Science Core Collection database. We then used bibliometric analysis to conduct performance analysis, citation analysis and co‐citation network of publications, together with keyword co‐occurrence analysis.ResultsSeven thousand five hundred and sixty‐four documents were finally retrieved, and the annual publications increased exponentially. The most productive authors were “KAOUK JH” and “GILL IS”, while USA, and 12 American affiliations such as CLEVELAND CLINIC FOUNDATION and MAYO CLINIC were far leading in this field. Journal of Urology and European Urology were journals with the highest citations and h‐index.DiscussionThrough literature reviewing plus co‐occurrence and clustering analysis, the therapeutic effects of partial nephrectomy (PN) versus RN on patients with localized renal cell carcinoma, different operative approaches of PN, and conservative NSS methods were deemed as the most focused topics.ConclusionThree aspects were the most important hotspots in this field. Firstly, how to provide the optimal management choices for different patients. Secondly, therapeutic effects of different management options and surgical techniques needed more prospective and randomized studies. Finally, more novel technologies and surgical techniques were required.
Establishment, culture and characterization of gemcitabine hydrochloride‐resistant human non‐small cell lung carcinoma cell line derived cancer stem cells
Authors: Demir Cevizlidere Bahar , Uysal Onur , Avci Huseyin , Gunes Bagis Sibel , Semerci Sevimli Tugba , Dincer Murat , Qomi Ekenel Emilia , Kara Suleyman Gokhan , Soykan Merve Nur , Eker Sariboyaci Ayla 
Published: June 2024

AbstractDue to their high expression profile of multi‐drug resistance genes, cancer stem cells (CSCs) are the main source of drug resistance. The aim of this study was to establish a gemcitabine‐hydrochloride‐resistant (rt) human non‐small cell lung cancer (hNSCLC) cell line and their CSC line to be used as disease models in various cancer studies. In the first phase of study, a gemcitabine hydrochloride‐rt hNSCLC line cells was produced by making them rt through periodic exposure to gemcitabine hydrochloride. This acquired gemcitabine‐hydrochloride‐rt hNSCLC cell line was characterized for resistance. Subsequently, a CSC population with a CD326 + CD133 + CD44+ phenotypes was immunoselectively isolated from gemcitabine hydrochloride‐rt hNSCLCs purified from a single cell by colony forming technology. This rt CSC line was characterized for both resistance and stemness. Rt and non‐rt CSCs were analyzed and compared with each other in terms of immunophenotyping the expression profiles of ALDH1, CD90, ABCG2, CD44 and MDR1, which are CSC specific markers, of demonstrating mitotic capacity with growth curve analysis and of their ability to form tumor spheroids in three different 3D cultures. The results of this study demonstrated for the first time the successful generation of both gemcitabine‐hydrochloride‐rt hNSCLC cells and CSCs derived from gemcitabine‐hydrochloride‐rt hNSCLC cells. It was also shown that isolated and characterized rt CSCs could proliferate and form tumor spheres in vitro using three different 3D in vitro techniques. It was shown that the cell surface markers CD326, CD133 and CD44 can serve as an antibody panel for CSCs.
Synergistic effects of glial cell line‐derived neurotrophic factor and base‐medium on in vitro culture of testicular tissue derived from prepubertal collared peccary
Authors: Silva Andreia Maria da , Pereira Ana Glória , Bezerra Luana Graziele Pereira , Brasil Andreza Vieira , Pereira Alexsandra Fernandes , de Oliveira Moacir Franco , Rodrigues Ana Paula Ribeiro , Ñaupas Lucy Vanessa Sulca , Comizzoli Pierre , Silva Alexandre Rodrigues 
Published: June 2024

AbstractWe evaluated the influence of different media plus various concentrations of Glial cell line‐derived neurotrophic factor (GDNF) during the in vitro culture (IVC) of testicular tissues from prepubertal collared peccary. Testes from 5 individuals were collected, fragmented and cultured for 28 days (34°C and 5% CO2). Culture media were Dulbecco's modified essential medium (DMEM) or stem cell serum free media (StemPro‐34™ SFM), both supplemented with various concentrations of GDNF (0, 10, or 20 ng/mL). Fragments were cultured on the flat surface of 0.75% agarose gel and were evaluated every 7 days for fragment area, histomorphology, cellular viability, and proliferative activity. Data were expressed as mean ± standard error and analyzed by Kruskal–Wallis's and Tukey test. Fragments area decreased over the 28 days‐culture, regardless of the treatment. For morphology, the StemPro‐37 SFM medium plus 10 ng/mL GDNF provided higher scores at all time points in comparison to DMEM using any GDNF concentration (p < .05). After 28 days, similar cellular viability (~70%) was observed in all treatments (p > .05). For proliferating cell nuclear antigen assay, only DMEM plus 10 ng/mL GDNF improved (p < .05) cellular proliferation on Days 14 and 28. Looking at argyrophilic nucleolar organizing regions, after 28 days, there were no differences among treatments regarding cell proliferative capacity for both spermatogonia and Sertoli cells (p > .05). In summary, the DMEM and StemPro‐34 SFM are adequate medium for IVC of prepubertal peccary testicular tissue. Supplementation with GDNF, especially at a 10 ng/mL concentration, appears to be essential for the maintenance of cell survival and proliferation.