bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety culture in a pharmacy setting using a pharmacy survey on patient safety culture: a cross-sectional study in China
Authors: Jia P L , Zhang L H , Zhang M M , Zhang L L , Zhang C , Qin S F , Li X L , Liu K X 
Published: July 2014

ObjectiveTo explore the attitudes and perceptions of patient safety culture for pharmacy workers in China by using a Pharmacy Survey on Patient Safety Culture (PSOPSC), and to assess the psychometric properties of the translated Chinese language version of the PSOPSC.DesignCross-sectional study.ParticipantsData were obtained from 20 hospital pharmacies in the southwest part of China.MethodsWe performed χ2test to explore the differences on pharmacy staff in different hospital and qualification levels and countries towards patient safety culture. We also computed descriptive statistics, internal consistency coefficients and intersubscale correlation analysis, and then conducted an exploratory factor analysis. A test–retest was performed to assess reproducibility of the items.ResultsA total of 630 questionnaires were distributed of which 527 were responded to validly (response rate 84%). The positive response rate for each item ranged from 37% to 90%. The positive response rate on three dimensions (‘Teamwork’, ‘Staff Training and Skills’ and ‘Staffing, Work Pressure and Pace’) was higher than that of Agency for Healthcare Research and Quality (AHRQ) data (p<0.05). There was a statistical difference in the perception of patient safety culture at different hospital and qualification levels. The internal consistency of the total survey was comparatively satisfied (Cronbach's α=0.89).ConclusionsThe results demonstrated that among the pharmacy staffs surveyed in China, there was a positive attitude towards patient safety culture in their organisations. Identifying perspectives of patient safety culture from pharmacists in different hospital and qualification levels are important, since this can help support decisions about action to improve safety culture in pharmacy settings. The Chinese translation of the PSOPSC questionnaire (V.2012) applied in our study is acceptable.
The uncertainty cascade in model fusion
Authors: Beven Keith , Lamb Rob 
Published: July 2014

Abstract
There are increasing demands in assessing the impacts of change on environmental systems to couple different model components together in a cascade, the outputs from one component providing the inputs to another with or without feedbacks in the coupling. Each model component will necessarily involve some uncertainty in its specification and simulations that can be conditioned using some observational data. Taking account of this uncertainty should result in more robust decision making and may change the nature of the decision made. The difficulty in environmental decision making is in making proper estimates of uncertainties when so many of the sources of uncertainty result from lack of knowledge (epistemic uncertainties) rather than uncertainty that can be treated as random variability (aleatory uncertainty). This is particularly the case for problems that involve cascades of model components. Examples are the use of UKCP09 climate scenarios in impact studies, flood risk assessment involving models of runoff generation and their impact on hydraulic models of flood plains, and integrated catchment management involving upstream to downstream surface and subsurface routing of water quality variables. The uncertainties are such that, even for relatively simple problems, they can result in wide ranges of potential outputs. This poses the questions that will be considered in this paper: how to take account of knowledge uncertainties in cascades of model components; and how to constrain the potential uncertainties for use in making decisions. In particular we highlight the difficulties of defining statistical likelihood functions that properly reflect the non-stationary uncertainty characteristics expected of epistemic sources of uncertainty.
Intra-Masking Dual-Rail Memory on LUT Implementation for SCA-Resistant AES on FPGA
Authors: Hoang Anh-Tuan , Fujino Takeshi 
Published: July 2014

In current countermeasure design trends against differential power analysis (DPA), security at gate level is required in addition to the security algorithm. Several dual-rail pre-charge logics (DPL) have been proposed to achieve this goal. Designs using ASIC can attain this goal owing to its backend design restrictions on placement and routing. However, implementing these designs on field programmable gate arrays (FPGA) without information leakage is still a problem because of the difficulty involved in the restrictions on placement and routing on FPGA.
This article describes our novel masked dual-rail pre-charged memory approach, called “intra-masking dual-rail memory (IMDRM) on LUT”, and its implementation on FPGA for Side-Channel Attack-resistant (SCA-resistant) AES. In the proposed design, all unsafe nodes, such as unmasking and masking, and parts of dual-rail memory with unsafe buses (buses that are not masked) are packed into a single LUT. This makes them balanced and independent of the placement and routing tools. Inputs and outputs of all LUTs are masked, and so can be considered safe signals. Several LUTs can be combined to create a safe SBox. The design is independent of the cryptographic algorithm, and hence, it can be applied to available cryptographic standards such as DES or AES as well as future standards. It requires no special placement or route constraints in its implementation. A correlation power analysis (CPA) attack on 1,000,000 traces of AES implementation on FPGA showed that the secret information is well protected against first-order side-channel attacks. Even though the number of LUTs used for memory in this implementation is seven times greater than that of the conventional unprotected single-rail memory table-lookup AES and three times greater than the implementation based on a composite field, it requires a smaller number of LUTs than all other advanced SCA-resistant implementations such as the wave dynamic differential logic, masked dual-rail pre-charge logic, and threshold.
Modeling biology with solver-aided programming languages
Authors: Bodik Rastislav 
Published: July 2014

A good model of a biological cell exposes secrets of the cell's signaling mechanisms, explaining diseases and facilitating drug discovery. Modeling cells is fundamentally a programming problem - it's programming because the model is a concurrent program that simulates the cell, and it's a problem because it is hard to write a program that reproduces all experimental observations of the cell faithfully.
In this talk, I will introduce solver-aided programming languages and show how they ease modeling biology as well as make programming accessible to non-programmers. Solver-aided languages come with constructs that delegate part of the programming problem to a constraint solver, which can be guided to synthesize parts of the program, localize its bugs, or act as a clairvoyant oracle.
I will describe our work on synthesis of stem cell models in c. elegans and then show how our framework called Rosette can rapidly implement a solver aided language in several domains, from programming by demonstration to spatial parallel programming.
Antiproliferative Mechanism of Action of the Novel Taxane Cabazitaxel as Compared with the Parent Compound Docetaxel in MCF7 Breast Cancer Cells
Authors: Azarenko Olga , Smiyun Gregoriy , Mah Jeffrey , Wilson Leslie , Jordan Mary Ann 
Published: July 2014

Abstract
Cabazitaxel, a novel chemotherapeutic taxane, is effective against docetaxel-resistant cells and tumors. It is approved for treatment of metastatic hormone-refractory prostate cancer in patients pretreated with docetaxel. Objective responses have been observed in many other cancers, including pretreated metastatic breast cancer. Cabazitaxel and docetaxel share a high degree of structural similarity. The basis for cabazitaxel's efficacy is unclear, and its mechanism has not been described. We compared the effects of cabazitaxel and docetaxel on MCF7 human breast cancer cells expressing fluorescent tubulin. Both drugs inhibited cell proliferation (IC50s, cabazitaxel, 0.4 ± 0.1 nmol/L, docetaxel, 2.5 ± 0.5 nmol/L) and arrested cells in metaphase by inducing mitotic spindle abnormalities. Drug concentrations required for half-maximal mitotic arrest at 24 hours were similar (1.9 nmol/L cabazitaxel and 2.2 nmol/L docetaxel). Cabazitaxel suppressed microtubule dynamic instability significantly more potently than docetaxel. In particular, cabazitaxel (2 nmol/L) suppressed the microtubule shortening rate by 59% (compared with 49% for 2 nmol/L docetaxel), the growing rate by 33% (vs. 19%), and overall dynamicity by 83% (vs. 64%). Cabazitaxel was taken up into cells significantly faster than docetaxel, attaining an intracellular concentration of 25 μmol/L within 1 hour, compared with 10 hours for docetaxel. Importantly, after washing, the intracellular cabazitaxel concentration remained high, whereas the docetaxel concentration was significantly reduced. The data indicate that the potency of cabazitaxel in docetaxel-resistant tumors is due to stronger suppression of microtubule dynamics, faster drug uptake, and better intracellular retention than occurs with docetaxel. Mol Cancer Ther; 13(8); 2092–103. ©2014 AACR.
Aspirin Use and Risk of Atrial Fibrillation in the Physicians' Health Study
Authors: Ofman Peter , Petrone Andrew B. , Peralta Adelqui , Hoffmeister Peter , Albert Christine M. , Djousse Luc , Gaziano J. Michael , Rahilly‐Tierney Catherine R. 
Published: July 2014

Background

Inflammatory processes have been associated with an increased risk of atrial fibrillation (
AF)
, potentially allowing for preventive therapy by anti‐inflammatory agents such as aspirin. However, the effect of chronic aspirin on the incidence of
AF
has not been evaluated in a prospective cohort followed for an extended period.

Methods and Results

This study was comprised of a prospective cohort of 23 480 male participants of the Physicians' Health Study. Aspirin intake and covariates were estimated using self‐reported questionnaires. Incident
AF
was ascertained through yearly follow‐up questionnaires. Cox's regression, with adjustment for multiple covariates, was used to estimate relative risk of
AF
. Average age at baseline was 65.1±8.9 years. During a mean follow‐up of 10.0 years, 2820 cases of
AF
were reported. Age‐standardized incidence rates were 12.6, 11.1, 12.7, 11.3, 15.8, and 13.8/1000 person‐years for people reporting baseline aspirin intake of 0, <14 days per year, 14 to 30 days per year, 30 to 120 days per year, 121 to 180 days per year, and >180 days per year, respectively. Multivariable adjusted hazard ratios (95% confidence interval) for incident
AF
were 1.00 (reference), 0.88 (0.76 to 1.02), 0.93 (0.76 to 1.14), 0.96 (0.80 to 1.14), 1.07 (0.80 to 1.14), and 1.04 (0.94 to 1.15) across consecutive categories of aspirin intake. Analysis of the data using time‐varying Cox's regression model to update aspirin intake over time showed similar results.

Conclusions

In a large cohort of males followed for a long period, we did not find any association between aspirin use and incident
AF
.
Head and Heart
Authors: Tieleman Teun 
Published: July 2014

In this paper, I examine what exactly is implied by (deutero-)Pauline references to the head as well as the heart in well-known statements from the Graeco-Roman background, i.e. the brain versus heart controversy as it arose and developed among medical scientists and philosophers. Two key passages are given separate treatment: 1Cor 12:12–31a and Col 2:19.
Embodied Inner Human Being
Authors: Weissenrieder Annette , Etzelmüller Gregor 
Published: July 2014

In this paper we take issue with George H. van Kooten’s recent argument that Paul’s concept of inner human being has a background in ancient philosophical treatises as a metaphor of the soul. We argue that its Greco-Roman physiological meaning was decisive in its adoption by Paul and that the split between ancient medicine and philosophy was not essential in antiquity. Ancient medical-philosophical texts did not focus on the core or center of a person but rather sought a deep understanding of his or her inner aspects. These texts sought to understand how it is that we can discover bodily information about this inner person and to what degree the relationship between the inner and outer person can be interpreted. At the same time, however, we are discussing Walter Burkert’s evolutionary understanding of Pauline’s concept of the inner and outer human being. Paul’s definition of the inner human being corresponds to recent anthropological concepts of embodiment insofar as the visible outer human being has an inside which, according to Paul, is not detached from the body, but must be grasped from a physical perspective.
Two new species of Kudinopasternakia Guţu, 1980 (Crustacea: Tanaidacea: Sphyrapodidae) with remarks on setology nomenclature
Authors: DOS SANTOS KÁTIA CHRISTOL 
Published: July 2014

Two new species of sphyrapodid tanaidaceans, Kudinopasternakia falconae n.sp. and Kudinopasternakia serejae n.sp., are described and illustrated from benthic samples taken at 680–790m depth in the Campos Basin, off the coast of south-eastern Brazil. The main characters used for the separation of the species are the number of maxillule palp distal setae, the number and length of spiniform setae on the ventral surface of the carpus and propodus of pereopod 1, the ornamentation of the ventral margin of the unguis of pereopods 4 to 6, and the pleonal epimera. Exopods were also observed on pereopods 4 and 5 of the manca of both new species. Some nomenclatural terms related to setae are discussed. A key to the genus Kudinopasternakia is presented.
Assisted dying – the debate: Videtur… sed contra
Authors: Graham Philip , Hughes Julian C. 
Published: July 2014

SummaryShould the law be changed to allow health professionals to assist mentally competent, terminally ill people to end their own lives? In this article Philip Graham (P.G.) puts the arguments in favour of such a change in the law and Julian Hughes (J.H.) opposes these arguments. J.H. then sets out why he believes such a law should not be passed and P.G., in turn, sets out counterarguments. Before concluding comments, both P.G. and J.H. independently make brief closing statements supporting their own positions.LEARNING OBJECTIVESUnderstand the differences between various types of ‘assisted dying’.Appreciate some of the ethical arguments in favour of and against changes in the law on assisted dying in the UK.Understand some of the empirical data involved in arguments about assisted dying.
A comparison of DSM and ICD classifications of mental disorder
Authors: Tyrer Peter 
Published: July 2014

SummaryMost disorders in medicine are classified using the ICD (initiated in Paris in 1900). Mental and behavioural disorders are classified using the DSM (DSM-I was published in the USA in 1952), but it was not until DSM-III in 1980 that it became a major player. Its success was largely influenced by Robert Spitzer, who welded its disparate elements, and Melvyn Shabsin, who facilitated its acceptance. Spitzer pointed out that most diagnostic conditions in psychiatry were poorly defined, showed poor reliability in test-retest situations, and were temporally unstable. The consequence was that the beliefs of the psychiatrist seemed to matter much more than the characteristics of the patient when it came to classification. Since DSM-III there has been a split between those who adhere to DSM because it is a better research classification and those who adhere to ICD because it allows more clinical discretion in making diagnoses. This article discusses the pros and cons of both systems, and the major criticisms that have been levelled against them.LEARNING OBJECTIVESUnderstand the principles and reasoning behind classification in medicine and psychiatry.Be able to describe the recent history of psychiatric classification.Be able to compare DSM and ICD classifications of mental disorder.
Cognitive analytic therapy at 30
Authors: Ryle Anthony , Kellett Stephen , Hepple Jason , Calvert Rachel 
Published: July 2014

SummaryCognitive analytic therapy (CAT) was formalised in 1984 by Anthony Ryle. It facilitated the clinical integration of psychodynamic therapy and personal construct/cognitive psychology. It is a brief, user-friendly relational therapy, applicable to the wide range of psychological problems typically seen in public mental health settings. It has recently been included in national guidelines for the treatment of personality disorder in the National Health Service. CAT provides a coherent model of development and psychopathology, which centrally views the self as both socially formed and embedded. Owing to its core relational grounding, CAT is being increasingly applied to team contexts/systems, enabling a ‘common language’ for team formulation/practice. It is also being successfully delivered as a group therapy. This article describes the development and unique features of the CAT model, analyses the current evidence base and identifies potential future directions for the model.LEARNING OBJECTIVESBe able to describe the core principles of the CAT approach.Appreciate the evidence base for CAT.Understand CAT's place today among talking therapies.
Hangover Square by Patrick Hamilton
Authors: Russ Tom C. 
Published: July 2014

SummaryPatrick Hamilton's (1904–1962) books are filled with gin and jealousy and depict obsessive desire in oppressive circumstances. His early financial success funded his heavy drinking, but also allowed him to write some of the best fiction of the 20th century. Following a depressive illness towards the end of his short life he never wrote again, leaving his final series of novels unfinished, the villain forever escaping justice. Hangover Square, set on the eve of the Second World War, tells the tense story of a man whose ambivalence for the woman he is pursuing (who has no interest in him) is manifested in two psychological states, between which he flips without warning. In one state he yearns for her, yet in the other has only one purpose – to kill her. Hamilton precisely describes a number of mental symptoms while not convincing readers of the implied diagnosis of schizophrenia. However, the similarities with a late-19th century French fuguer are clear and perhaps this condition provides a better frame for the main character's experiences.
Prescription of antipsychotics in people with dementia
Authors: Ballard Clive , Corbett Anne , Howard Robert 
Published: July 2014

SummaryGerhard et al clarify our understanding of mortality associated with antipsychotic use in people with dementia, by demonstrating a clear dose relationship and highlighting key questions regarding the relative mortality risk of different atypical antipsychotics. The study also suggests that antipsychotics may confer risks of increased mortality in older people without dementia.
Surgery Alone Versus Chemoradiotherapy Followed by Surgery for Stage I and II Esophageal Cancer: Final Analysis of Randomized Controlled Phase III Trial FFCD 9901
Authors: Mariette Christophe , Dahan Laetitia , Mornex Françoise , Maillard Emilie , Thomas Pascal-Alexandre , Meunier Bernard , Boige Valérie , Pezet Denis , Robb William B. , Le Brun-Ly Valérie , Bosset Jean-François , Mabrut Jean-Yves , Triboulet Jean-Pierre , Bedenne Laurent , Seitz Jean-François 
Published: July 2014

Purpose Although often investigated in locally advanced esophageal cancer (EC), the impact of neoadjuvant chemoradiotherapy (NCRT) in early stages is unknown. The aim of this multicenter randomized phase III trial was to assess whether NCRT improves outcomes for patients with stage I or II EC. Methods The primary end point was overall survival. Secondary end points were disease-free survival, postoperative morbidity, in-hospital mortality, R0 resection rate, and prognostic factor identification. From June 2000 to June 2009, 195 patients in 30 centers were randomly assigned to surgery alone (group S; n = 97) or NCRT followed by surgery (group CRT; n = 98). CRT protocol was 45 Gy in 25 fractions over 5 weeks with two courses of concomitant chemotherapy composed of fluorouracil 800 mg/m2 and cisplatin 75 mg/m2. We report the long-term results of the final analysis, after a median follow-up of 93.6 months. Results Pretreatment disease was stage I in 19.0%, IIA in 53.3%, and IIB in 27.7% of patients. For group CRT compared with group S, R0 resection rate was 93.8% versus 92.1% (P = .749), with 3-year overall survival rate of 47.5% versus 53.0% (hazard ratio [HR], 0.99; 95% CI, 0.69 to 1.40; P = .94) and postoperative mortality rate of 11.1% versus 3.4% (P = .049), respectively. Because interim analysis of the primary end point revealed an improbability of demonstrating the superiority of either treatment arm (HR, 1.09; 95% CI, 0.75 to 1.59; P = .66), the trial was stopped for anticipated futility. Conclusion Compared with surgery alone, NCRT with cisplatin plus fluorouracil does not improve R0 resection rate or survival but enhances postoperative mortality in patients with stage I or II EC.
JSim, an open-source modeling system for data analysis
Authors: Butterworth Erik , Jardine Bartholomew E. , Raymond Gary M. , Neal Maxwell L. , Bassingthwaighte James B. 
Published: July 2014

JSim is a simulation system for developing models, designing experiments, and evaluating hypotheses on physiological and pharmacological systems through the testing of model solutions against data. It is designed for interactive, iterative manipulation of the model code, handling of multiple data sets and parameter sets, and for making comparisons among different models running simultaneously or separately. Interactive use is supported by a large collection of graphical user interfaces for model writing and compilation diagnostics, defining input functions, model runs, selection of algorithms solving ordinary and partial differential equations, run-time multidimensional graphics, parameter optimization (8 methods), sensitivity analysis, and Monte Carlo simulation for defining confidence ranges. JSim uses Mathematical Modeling Language (MML) a declarative syntax specifying algebraic and differential equations. Imperative constructs written in other languages (MATLAB, FORTRAN, C++, etc.) are accessed through procedure calls. MML syntax is simple, basically defining the parameters and variables, then writing the equations in a straightforward, easily read and understood mathematical form. This makes JSim good for teaching modeling as well as for model analysis for research. For high throughput applications, JSim can be run as a batch job. JSim can automatically translate models from the repositories for Systems Biology Markup Language (SBML) and CellML models. Stochastic modeling is supported. MML supports assigning physical units to constants and variables and automates checking dimensional balance as the first step in verification testing. Automatic unit scaling follows, e.g. seconds to minutes, if needed. The JSim Project File sets a standard for reproducible modeling analysis: it includes in one file everything for analyzing a set of experiments: the data, the models, the data fitting, and evaluation of parameter confidence ranges. JSim is open source; it and about 400 human readable open source physiological/biophysical models are available athttp://www.physiome.org/jsim/.