bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiological Analysis of Prognosis of 496 Japanese Patients with Progressive Systemic Sclerosis (SSc)
Authors: Nishioka Kiyoshi , Katayama Ichiro , Kondo Hirobumi , Shinkai Hiroshi , Ueki Hiroaki , Tamaki Kunihiko , Takehara Kazuhiko , Tajima Shingo , Maeda Manabu , Hayashi Seiji , Kodama Hajime , Miyachi Yoshiki , Mizutani Hitoshi , Fujisaku Atsushi , Sasaki Tetsuo , Shimizu Masatoshi , Kaburagi Junichi ,   Scleroderma Research Committee Japan
Published: April 2015

AbstractFor the first time, we performed an epidemiological study of SSc in Japan to study the factors influencing prognosis, survival rate and cause of death of Japanese SSc patients and to compare our data with those from foreign countries.Prognosis of 496 Japanese patients with progressive systemic sclerosis (SSc) was analyzed based on clinical data described in case cards provided by the members of the Scleroderma Research Committee of the Japanese Ministry of Health and Welfare. The essential observation period was from 5 to 20 years, at ending in 1994.Ninety patients died (males 11, females 79). The age of onset of the deceased patients was significantly higher than that of surviving patients (deceased. 45.6 yrs, surviving 41.3 yrs). Statistically significant factors for a poor prognosis were as follows: Barnett type III > type II > type I, positive for anti‐Scl‐70 antibody, negative for anti‐centromere antibody. The survival rate at 5 years after the onset of the disease was 0.937, followed by 0.82 at 10 years, 0.567 at 20 years and 0.40 at 30 years after the onset. Sex was not a predictor for prognosis, although male patients died at an earlier stage of the disease. The most common causes of death were heart failure, pulmonary insufficiency, lung fibrosis, and renal failure. Twenty‐four patients had cancer of which 13 were lung cancers.The current status of the survival rate and prognostic factors of 496 Japanese SSc patients is summarized. In future, more well‐controlled studies using the same criteria should be performed for the better understanding and management of SSc.
Pemphigoid and Pemphigus Foliaceus Successfully Treated with Topical Corticosteroids
Authors: Muramatsu Tsutomu , Iida Takashi , Shirai Toshihiko 
Published: April 2015

AbstractSix patients with pemphigoid and three patients with pemphigus foliaceus were successfully treated with topical corticosteroids. This was especially effective in cases of pretibial localized pemphigoid and in mild cases of bullous pemphigoid and pemphigus foliaceus with negative or low‐titer circulating autoantibodies.
Bony Anomalies in a Patient with Reticulate Acropigmentation of Kitamura
Authors: El‐Hoshy Khaled , Hashimoto Ken 
Published: April 2015

AbstractReticulate acropigmentation of Kitamura [RAPK] is a rare pigmentary genodermatosis. This is a case report of a 23‐year‐old Saudi female who started manifesting the disorder in the 2nd decade. The patient had bony abnormalities in the form of absence of terminal phalanges of the 2nd, 3rd and 4th toes. These bone anomalies are extremely rare, and the association has never been described before in the literature.
Identification of mRNA‐Rich Keratinocytes in the Basal/Suprabasal Layers of Psoriatic Skin
Authors: Yokota Koichi , Matsue Hiroyuki , Shibaki Akihiko , Kawashima Toshimitsu , Kobayashi Hitoshi , Ohkawara Akira 
Published: April 2015

AbstractIn this study, we examined the relative amounts of mRNA expressed in normal versus psoriatic epidermis, using in situ hybridization with a biotinylated oligonucleotide poly d(T) probe. The hybridization image was analyzed by Laser Scanning Confocal Microscopy (LSCM). In normal human skin, hybridization signals were detected homogeneously throughout the epidermis, mostly in nucleus. These signals disappeared following RNase T2 or RNase A treatment, indicating that the target for this probe is RNA; by implication, mRNA. In psoriatic lesions, the overall signal intensity was significantly elevated, especially in the basal/suprabasal layers. Moreover, those signals were most prominent in the cytoplasm, not in the nucleus. In contrast, the signals of uninvolved epidermis adjacent to the psoriatic lesions were indistinguishable from those of normal skin in both signal intensity and hybridization profile. Our data are consistent with the notion that one of the characteristic features of psoriasis is an elevated (or uncontrolled) synthesis of mRNA and proteins.
Necrotizing Fasciitis Due to Group A Streptococci: A Clinicopathological Study of Six Patients
Authors: Misago Noriyuki , Narisawa Yutaka , Ryu Seiji , Gotoh Yumiko , Tanaka Tatsurou , Yokoyama Maiko , Kohda Hiromu 
Published: April 2015

AbstractThe recent worldwide appearance of invasive group A streptococcal infections has again called attention to streptococcal necrotizing fasciitis. However, in contrast to polymicrobial necrotizing fasciitis, the streptococcal form has not been thoroughly studied clinically. The objective of the study was to elucidate the characteristic features of recent cases of necrotizing fasciitis due exclusively to pure group A streptococci. We encountered six patients with these criteria at a single hospital in Japan during the last 12 years. A clinicopathological analysis was performed in these six patients. In three patients, the clinical signs and the laboratory findings were characteristic of systemic toxicity. In this group, the clinical presentation was a pale or blue‐gray lesion associated with severe intravascular coagulation histologically involving the vessels in the lesion. In the three patients without signs of systemic toxicity, a swollen, erythematous skin lesion persisted for as long as one week; histologically, the intravascular coagulation within these lesions was mild. In clinicopathological terms, the entity in these six patients could be clearly classified as either fulminant or subacute. In the fulminant type, immediate surgical debridement of necrotic fascia is required; in the subacute type, incision and drainage alone are sufficient.
Solitary Piloleiomyoma with an Unusual Clinical Appearance
Authors: Izumi Tatsuya , Kai Misaki , Shimizu Hiroshi , Tajima Shingo 
Published: April 2015

AbstractWe present a 66‐year‐old man with a solitary piloleiomyoma on the forehead. The lesion had unusual clinical features; it was a crusted and dome‐shaped nodule, which exhibited rapid growth. Histology revealed the typical features of piloleiomyoma. The unusual clinical features may have been due to its unique location, in which the downward growth of the tumor was prevented by the underlying frontal bone.
Evaluation of Sialyl Lewisx Antigen in the Skin and the Sera of Patients with Psoriasis Vulgaris
Authors: Ohta Keiji , Furukawa Fukumi , Fujita Mayumi , Kashihara‐Sawami Mari , Horiguchi Yuji , Ueda Masamichi , Kurokawa Shigeko , Takigawa Masahiro , Imamura Sadao 
Published: April 2015

AbstractThe roles of sialyl‐Lewisx antigen were evaluated in the pathogenesis of psoriasis. Sialyl‐Lewisxexpression was investigated immunohistochemically in the epidermis of normal human skin and erythematous lesional skin of psoriasis vulgaris by avidin‐biotin‐peroxidase complex procedures. A few sialyl‐Lewisx positive dendritic cells were detected in the epidermis of normal human skin. In 7 out of 9 cases of psoriasis vulgaris, the number of sialyl‐Lewisx‐positive epidermal dendritic cells increased in the erythematous lesion over the adjacent normal skin; there were no marked changes in the numbers of CD1a‐positive cells in the epidermis between the two skin types. In the double immunofluorescence studies, more than half of the sialyl‐Lewisx‐positive epidermal cells in psoriatic erythema were stained with a monoclonal Lag antibody that specifically reacts with Birbeck granules and related structures of human Langerhans cells. Furthermore, we determined the changes in serum levels of sialyl‐Lewisx antigens in patients with psoriasis. Although levels in the sera were not significantly elevated over those of controls, the increases correlated with the degree of disease activity. These findings suggest that sialyl‐Lewisx antigen is possibly involved in the development of psoriasis.
A Case of Pemphigus Vulgaris with Esophageal Involvement
Authors: Amichai Boaz , Grunwald Marcelo H. , Gasper Naava , Finkelstein Eve , Halevy Sima 
Published: April 2015

AbstractEsophageal involvement in pemphigus vulgaris is rare, found more in women than in men, and can be the only manifestation of pemphigus. Esophageal involvement had been reported only among patients with pemphigus vulgaris and not in patients with other forms of pemphigus. We describe a case of pemphigus vulgaris in which the esophagus was severely involved with only few oral lesions and no involvement of the skin or oropharynx.
Bowen's Disease: Statistical Study of a 10 Year Period
Authors: Kovács Anikó , Yonemoto Kohzoh , Katsuoka Kensei , Nishiyama Shigeo , Harhai Imre 
Published: April 2015

AbstractAccording to histological records, a total of 74 patients were diagnosed with Bowen's disease (B.d.) between 1 January 1984 and 31 December 1993 at the Department of Dermatology of Kitasato University. There was slight female predominance (36 ♂, 38 ♀), and 73% of the patients were older than 60 years; the mean age was 66.8 years. Fifteen patients had multiple (two‐five) lesions. In 13 patients, other benign skin lesions were also found. Arsenic exposure as etiologic factor could have been present in 2 cases. Only 3 patients had other associated malignant tumors, which does not confirm the paraneoplastic nature of B.d. One‐fifth of the lesions were on sun‐exposed areas (head, neck and hands). Although we excluded invasive carcinomas from our statistical study, we mention the 8 invasive carcinomas developing from B.d. in that period. Histopathological classification of B.d. is uncommon. Classifying our cases by Darier's histopathological classification, 63.3% of them belonged to the lenticular type. The malignant potential of different histopathological types of B.d. needs further investigation.
Intradermal Dermoid Cyst Associated with Occult Spinal Dysraphism
Authors: Misago Noriyuki , Abe Masamitsu , Kohda Hiromu 
Published: April 2015

AbstractA 2‐year‐old boy with congenital lumbosacral skin lesions is described. He presented with associated occult spina bifida and a sagittal cleft of the vertebral body deep in the skin lesions. The skin lesions presented as a combination of a lipoma, telangiectasia, mild hypertrichosis, and a dermoid cyst. Magnetic resonance imaging (MRI) revealed that the lipoma extended to the spina bifida region, but that it did not connect to the dura. MRI also demonstrated no other spinal lesions requiring surgical treatment. The intradermal location of the dermoid cyst observed in our patient was unusual. We discuss the location of dermoid cysts in the lumbosacral region associated with spinal dysraphism.
Anti‐Lipase Activity of Kampo Formulations, Coptidis Rhizoma and Its Alkaloids against Propionibacterium acnes
Authors: Higaki Shuichi , Nakamura Motokazu , Morohashi Masaaki , Hasegawa Yoshinori , Yamagishi Takayoshi 
Published: April 2015

AbstractAnti‐lipase activity of Kampo formulations, Coptidis Rhizoma (CR), and its alkaloids against Propionibacterium. acnes were examined in vitro. The amounts of propionic and butyric acids in the medium were measured as growth and lipase activity of P. acnes, respectively. In tributyrin‐PYG medium with each concentration of Kampo formulation, CR, or the alkaloids added, the production of propionic acid was suppressed remarkably more than that of butyric acid. The suppression of production of these acids by CR was higher than that of the alkaloids. Furthermore, no lipase‐negative colonies were found on the medium to which Kampo formulations were added.From these observations, we concluded that not only Kampo formulations and CR, but also their alkaloids, showed suppression of growth of P. acnes, which reduced anti‐lipase activity. Furthermore, it was suggested that Kampo formulations and Kampo crude drugs with anti‐lipase activity to P. acnes should be synergistic when their ingredients are combined.
Counts of Common and Atypical Melanocytic Nevi in Korean Young Men: Assessment of Their Risks and Correlations with Associated Factors
Authors: Kim Young Gull , Cho Kwang Hyun 
Published: April 2015

AbstractTwo hundred and thirty‐five Korean young men were examined for the count of melanocytic nevi (MN). The mean count of common MN of at least 2 mm diameter was 16.1. Three subjects had more than 50 common MN and another four had clinically atypical MN. We determined skin phototype by interview with questionnaires in the same persons as proposed by Fitzpatrick. All subjects were classified with respect to skin phototype and the number of previous sunburns. The correlations between common MN and the skin phototype or the number of previous sunburns were statistically analyzed. The skin phototype showed the correlation with the number of common MN, which means if skin phototype of any subject belongs to type I, he could to be predicted to have many more common MN than subjects with darker phototypes, like type VI. The correlation between number of previous sunburns and number of common MN was not statistically significant. This study shows persons at moderate risk of cutaneous melanoma (CM) do exist and skin phototype is associated with the prevalence of common MN in Koreans.
Successful Treatment of a Therapy‐Resistant Severely Pruritic Skin Eruption of Malignancy‐Associated Dermatomyositis with High‐Dose Intravenous Immunoglobulin
Authors: Kikuchi‐Numagami Katsuko , Sato Maki , Tagami Hachiro 
Published: April 2015

AbstractMalignancy‐associated dermatomyositis developing in a middle‐aged Japanese female was successfully treated by removal of her gastric cancer. However, five years later, concomitant with catching a cold, her severely pruritic skin lesions recurred on exposed areas. Six years after the start of corticosteroid therapy for her annoying skin lesion, we started to treat her with high‐dose intravenous immunoglobulin (IVIG) infusion therapy because of the difficulty of reducing the dosage of oral prednisone, that had secondarily induced adverse effects. After five courses of the therapy, her recalcitrant, pruritic, erythematous skin lesions improved dramatically, enabling a satisfactory reduction in the dosage of oral prednisone. There were no significant adverse side effects with IVIG.
In vitro Interleukin‐5 (IL‐5) Production by Peripheral Blood Mononuclear Cells from Patients with Drug Hypersensitivity
Authors: Mikami Chikage , Ochiai Kenichi , Kagami Masaru , Tomioka Hisao , Tanabe Emiko 
Published: April 2015

AbstractIt has been shown that CD4+ lymphocytes and eosinophils pathologically infiltrate the dermis in skin eruptions due to hypersensitivity to the administration of certain drugs associated with peripheral eosinophilia. However, the mechanisms involved in drug related skin eruptions with eosinophilia are largely unknown. There are several methods of diagnosing drug hypersensitivity, but no single in vitro method is available for the detection of the sensitizing drug.In order to elicit the mechanism of drug related skin eruption with eosinophilia and to establish effective methods for diagnosing drug hypersensitivity, we studied in vitro IL‐5 production by peripheral mononuclear cells (PBMC) from patients with drug related skin eruptions (n=8). Significant increase in IL‐5 from exposure to drug alone (n=3) and drug with PHA (n=3) were noted, whereas PBMC from normal subjects (n=7) exhibited no such stimulation. Six of the eight cases showed a significant decrease in the number of peripheral blood eosinophils when the skin eruptions healed compared with those at the onset. Histopathological features revealed mild to moderate infiltration of eosinophils. Immunohistopathologically, infiltration of CD4+ and CD8+ lymphocytes and CD4+ cells were predominant within the dermis of drug related skin eruption sites in all cases. This study suggested that the IL‐5 production of sensitized mononuclear cells might be a critical mediator in drug hypersensitivity with eosinophilia and an important diagnostic marker.
Distribution of Lectin UEA‐I in Trichilemmal Carcinoma, Squamous Cell Carcinoma, and Other Epithelial Tumors of the Skin
Authors: Ko Toshiko , Muramatsu Tsutomu , Shirai Toshihiko 
Published: April 2015

AbstractTrichilemmal carcinoma (TLC) is a cutaneous appendage tumor. In some cases, the histological distinction between TLC and squamous cell carcinoma (SCC) is difficult with hematoxylin & eosin staining. In the present study, in order to establish a simple and reliable method for distinguishing between TLC and SCC, we examined the lectin Ulex europaeus agglutinin‐I (UEA‐I)‐binding patterns of TLC (4 cases), SCC (10 cases), malignant proliferating trichilemmal cyst (MPTC) (3 cases), Bowen's disease (4 cases), Bowen's carcinoma (4 cases), actinic keratosis (4 cases), basal cell carcinoma (8 cases), and eccrine porocarcinoma (1 case). In normal skin samples, UEA‐I was strongly positive in the outer root sheath cells of the hair follicle and weakly positive in the granular layers of the epidermis. UEA‐I stained the tumor cells of TLC clearly and some MPTC and Bowen's disease cells weakly. This result indicates that histochemical staining with UEA‐I is a simple and useful method for distinguishing between TLC and SCC of the skin.
Comparison of the Effects of Intralesional Interferon Alfa‐2a, 2b and the Combination of 2a and 2b in the Treatment of Basal Cell Carcinoma
Authors: Alpsoy Erkan , Yilmaz Ertan , Başaran Erdal , Yazar Şahin 
Published: April 2015

AbstractInterferons (IFN), especially alfa‐2a and 2b, are potent inhibitors of normal and malignant cell growth and effective choices in the treatment of basal cell carcinoma (BCC).The aim of the study was to evaluate the effectiveness of the IFN alfa‐2a and 2b, and whether this effect may be increased by their combination.A total of 45 patients with histopathologically confirmed BCC were divided into three groups, equally. Groups 1, 2 and 3 were treated with intralesional IFN alfa‐2a, 2b, and the combination of 2a and 2b, respectively. Lesions were injected three times weekly in Groups 1 and 2 (total ten injections). IFN alfa‐2a and 2b were injected alternately in Group 3 (5 IFN alfa‐2a and 5 IFN alfa‐2b). Eight weeks after completion of therapy, cytologic specimens were taken, and all cases were evaluated clinically and cytologically.Ten (66.6%) patients had a complete response (CR) and 5 (33.3%) had a partial response (PR) in Group 1. Patients in Group 2 showed 10 (66.6%) CR, 4 (26.6%) PR, and 1 (6.6%) non response. In Group 3, 11 (73.3%) patients had CR and 4 (26.6%) had PR. Follow‐up periods ranged from 6–24 months, and no recurrences have been observed.These results suggest that IFN alfa‐2a, 2b, and the combination of 2a and 2b appear to be effective choices for the treatment of BCC; the effectiveness is not increased by their combination.
Accordion‐like Structure of Terminal Hair Follicles of the Human Scalp
Authors: Narisawa Yutaka , Hashimoto Ken , Kohda Hiromu 
Published: April 2015

AbstractTerminal hair follicles extracted after ethylenediaminetetraacetic acid treatment preserved the basal cell surface of the outer root sheath well enough to examine the outer surface in detail. Light microscopic observations of whole mount specimens revealed several sawtooth‐like structures of follicular epithelium in the lower portion of terminal hair follicle. Vertical sections of the human scalp also showed several invaginations of the outer root sheath of terminal hair follicles in the lower portion, not in association with the arrector pili muscle. Scanning electron microscopy of the same specimens demonstrated accordion‐like structures below the sebaceous gland in the lower half of anagen terminal hair follicles and surrounding the entire circumference of the follicles. Sawtooth‐like structures were unilaterally observed at the level of the middle or lower portion below the sebaceous gland. With transmission electron microscopy, these structures were seen as undulations of basal cells which preserved hemidesmosomes, although the basal lamina had been peeled off during the extraction procedure. Thus, this accordion‐like structure is a genuine structural variation of some human anagen hair follicles and not an artifact.
Successful Treatment of Scleroderma with PUVA Therapy
Authors: Kanekura Takuro , Fukumaru Seita , Matsushita Shigeto , Terasaki Kenjiro , Mizoguchi Shimako , Kanzaki Tamotsu 
Published: April 2015

AbstractPUVA therapy was carried out on four patients with scleroderma; three of them had cutaneous manifestations of progressive systemic sclerosis and one other exhibited generalized morphea. PUVA therapy was given with daily doses of 0.25 J/cm2 or 0.4 J/cm2 for 3–8 weeks, resulting in total doses between 3.5 J/cm2 and 9.6 J/cm2. All four patients responded well to this treatment; improvements of hand closure, skin sclerosis index, and flexion of fingers or knee joints were obtained. Thus, PUVA appeared to be beneficial for treating scleroderma.
Humoral Hypercalcemia of Malignancy with Elevated Plasma PTHrP, TNFα and IL‐6 in Cutaneous Squamous Cell Carcinoma
Authors: Mori Hiroki , Aoki Kazuhiro , Katayama Ichirou , Nishioka Kiyoshi , Umeda Tadashi 
Published: April 2015

AbstractA case of humoral hypercalcemia of malignancy in cutaneous squamous cell carcinoma is reported. An 82‐year‐old male underwent surgery for cutaneous squamous cell carcinoma (SCC) of the left hand in 1992. He subsequently developed clouding of consciousness with remarkable hypercalcemia, a high parathyroid hormone related protein (PTHrP) level, and elevated plasma cytokine levels [tumor necrosis factor α (TNFα), interleukin‐6 (IL‐6)]. Diagnosis of humoral hypercalcemia of malignancy (HHM) was made on the basis of these findings. He died of renal insufficiency due to this hypercalcemia in spite of several replacement therapies and chemotherapies. The PTHrP might have derived from the SCC and have been responsible for the HHM in conjunction with IL‐6 and TNFα.
Lymphoepithelioma‐like Carcinoma of the Skin
Authors: Takayasu Susumu , Yoshiyama Masako , Kurata Sotaro , Terashi Hiroto 
Published: April 2015

AbstractLymphoepithelioma‐like carcinoma of the skin is a rare tumor with a microscopic resemblance to lymphoepitheliomatous tumors of the nasopharynx. A 62‐year‐old woman exhibited such a tumor on the nose together with regional lymph node metastases. Histologically, irregular islands of atypical epithelial cells unconnected to the overlying epidermis were surrounded by or mixed with numerous lymphocytes in the primary tumor. No squamous or glandular differentiation was present. Metastases to the submandibular lymph nodes appeared as glassy squamous cells that resembled trichilemmal keratinization. Staining of the tumor tissues with S‐100 protein antibody revealed the presence of numerous short dendritic cells in clusters of epidielial cells. Total resection and adjunctive radiotherapy have led to a 6‐year period free of recurrence. This is the second case report of this condition in Japan.