bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antidepressant, antipsychotic and psychological interventions in subjects at high clinical risk for psychosis: OASIS 6-year naturalistic study
Authors: Fusar-Poli P. , Frascarelli M. , Valmaggia L. , Byrne M. , Stahl D. , Rocchetti M. , Codjoe L. , Weinberg L. , Tognin S. , Xenaki L. , McGuire P. 
Published: October 2014

Background.Recent randomized controlled trials suggest some efficacy for focused interventions in subjects at high risk (HR) for psychosis. However, treating HR subjects within the real-world setting of prodromal services is hindered by several practical problems that can significantly make an impact on the effect of focused interventions.Method.All subjects referred to Outreach and Support in South London (OASIS) and diagnosed with a HR state in the period 2001–2012 were included (n = 258). Exposure to focused interventions was correlated with sociodemographic and clinical characteristics at baseline. Their association with longitudinal clinical and functional outcomes was addressed at follow-up.Results.In a mean follow-up time of 6 years (s.d. = 2.5 years) a transition risk of 18% was observed. Of the sample, 33% were treated with cognitive behavioural therapy (CBT) only; 17% of subjects received antipsychotics (APs) in addition to CBT sessions. Another 17% of subjects were prescribed with antidepressants (ADs) in addition to CBT. Of the sample, 20% were exposed to a combination of interventions. Focused interventions had a significant relationship with transition to psychosis. The CBT + AD intervention was associated with a reduced risk of transition to psychosis, as compared with the CBT + AP intervention (hazards ratio = 0.129, 95% confidence interval 0.030–0.565, p = 0.007).Conclusions.There were differential associations with transition outcome for AD v. AP interventions in addition to CBT in HR subjects. These effects were not secondary to baseline differences in symptom severity.
Real Presence in the Eucharist and time-travel
Authors: PICKUP MARTIN 
Published: October 2014

AbstractThis article aims to bring some work in contemporary analytic metaphysics to discussions of the Real Presence of Christ in the Eucharist. I will show that some unusual claims of the Real Presence doctrine exactly parallel what would be happening in the world if objects were to time-travel in certain ways. Such time-travel would make ordinary objects multiply located, and in the relevantly analogous respects. If it is conceptually coherent that objects behave in this way, we have a model for the behaviour of the Eucharist which shows the doctrine to be coherent, at least with respect to the issues discussed.
Low and high repetition frequency femtosecond lasers processing of tungsten-based thin film
Authors: Gaković B. , Petrović S. , Krmpot A. , Pantelić D. , Jelenković B. , Stratakis E. , Fotakis C. 
Published: October 2014

AbstractIn this work we reported low and high repetition frequency femtosecond laser-induced modifications of tungsten-based thin film. The tungsten-titanium (WTi) thin film, thickness of 190 nm, was deposited by sputtering on single crystal Si (100) wafer. Irradiations were performed in air by linearly polarized and focused femtosecond laser beams with following parameters: (1) pulse duration 160 fs, wavelength 800 nm, laser repetition frequency (LRF) 75 MHz — high LRF, and (2) duration 40 fs, wavelength 800 nm, LRF of 1 kHz — low LRF. The results of femtosecond lasers processing of the WTi thin film revealed laser induced periodical surface structures (LIPSS) in the case of low LRF regime. LIPSSs were formed with different periodicity and different orientation to the laser polarization at the surface: micro-scale LIPSSs with orientation perpendicular to the laser polarization and nano-scale LIPSSs parallel and perpendicular to the laser polarization. After processing of the WTi/Si system in high LRF regime ablation and nano-particles formation were registered.
Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease
Authors: Gilsbach Ralf , Preissl Sebastian , Grüning Björn A. , Schnick Tilman , Burger Lukas , Benes Vladimir , Würch Andreas , Bönisch Ulrike , Günther Stefan , Backofen Rolf , Fleischmann Bernd K. , Schübeler Dirk , Hein Lutz 
Published: October 2014

AbstractThe heart is a highly specialized organ with essential function for the organism throughout life. The significance of DNA methylation in shaping the phenotype of the heart remains only partially known. Here we generate and analyse DNA methylomes from highly purified cardiomyocytes of neonatal, adult healthy and adult failing hearts. We identify large genomic regions that are differentially methylated during cardiomyocyte development and maturation. Demethylation of cardiomyocyte gene bodies correlates strongly with increased gene expression. Silencing of demethylated genes is characterized by the polycomb mark H3K27me3 or by DNA methylation. De novo methylation by DNA methyltransferases 3A/B causes repression of fetal cardiac genes, including essential components of the cardiac sarcomere. Failing cardiomyocytes partially resemble neonatal methylation patterns. This study establishes DNA methylation as a highly dynamic process during postnatal growth of cardiomyocytes and their adaptation to pathological stress in a process tightly linked to gene regulation and activity.
A comprehensive database of the geographic spread of past human Ebola outbreaks
Authors: Mylne Adrian , Brady Oliver J. , Huang Zhi , Pigott David M. , Golding Nick , Kraemer Moritz U.G. , Hay Simon I. 
Published: October 2014

AbstractEbola is a zoonotic filovirus that has the potential to cause outbreaks of variable magnitude in human populations. This database collates our existing knowledge of all known human outbreaks of Ebola for the first time by extracting details of their suspected zoonotic origin and subsequent human-to-human spread from a range of published and non-published sources. In total, 22 unique Ebola outbreaks were identified, composed of 117 unique geographic transmission clusters. Details of the index case and geographic spread of secondary and imported cases were recorded as well as summaries of patient numbers and case fatality rates. A brief text summary describing suspected routes and means of spread for each outbreak was also included. While we cannot yet include the ongoing Guinea and DRC outbreaks until they are over, these data and compiled maps can be used to gain an improved understanding of the initial spread of past Ebola outbreaks and help evaluate surveillance and control guidelines for limiting the spread of future epidemics.
The Biobanking Analysis Resource Catalogue (BARCdb): a new research tool for the analysis of biobank samples
Authors: Galli Joakim , Oelrich Johan , Taussig Michael J. , Andreasson Ulrika , Ortega-Paino Eva , Landegren Ulf 
Published: October 2014

Abstract
We report the development of a new database of technology services and products for analysis of biobank samples in biomedical research. BARCdb, the Biobanking Analysis Resource Catalogue, is a freely available web resource, listing expertise and molecular resource capabilities of research centres and biotechnology companies. The database is designed for researchers who require information on how to make best use of valuable biospecimens from biobanks and other sample collections, focusing on the choice of analytical techniques and the demands they make on the type of samples, pre-analytical sample preparation and amounts needed. BARCdb has been developed as part of the Swedish biobanking infrastructure (BBMRI.se), but now welcomes submissions from service providers throughout Europe. BARCdb can help match resource providers with potential users, stimulating transnational collaborations and ensuring compatibility of results from different labs. It can promote a more optimal use of European resources in general, both with respect to standard and more experimental technologies, as well as for valuable biobank samples. This article describes how information on service and reagent providers of relevant technologies is made available on BARCdb, and how this resource may contribute to strengthening biomedical research in academia and in the biotechnology and pharmaceutical industries.
Natural Variation in Sensitivity to a Loss of Chloroplast Translation in Arabidopsis
Authors: Parker Nicole , Wang Yixing , Meinke David 
Published: October 2014

Abstract
Mutations that eliminate chloroplast translation in Arabidopsis (Arabidopsis thaliana) result in embryo lethality. The stage of embryo arrest, however, can be influenced by genetic background. To identify genes responsible for improved growth in the absence of chloroplast translation, we examined seedling responses of different Arabidopsis accessions on spectinomycin, an inhibitor of chloroplast translation, and crossed the most tolerant accessions with embryo-defective mutants disrupted in chloroplast ribosomal proteins generated in a sensitive background. The results indicate that tolerance is mediated by ACC2, a duplicated nuclear gene that targets homomeric acetyl-coenzyme A carboxylase to plastids, where the multidomain protein can participate in fatty acid biosynthesis. In the presence of functional ACC2, tolerance is enhanced by a second locus that maps to chromosome 5 and heightened by additional genetic modifiers present in the most tolerant accessions. Notably, some of the most sensitive accessions contain nonsense mutations in ACC2, including the “Nossen” line used to generate several of the mutants studied here. Functional ACC2 protein is therefore not required for survival in natural environments, where heteromeric acetyl-coenzyme A carboxylase encoded in part by the chloroplast genome can function instead. This work highlights an interesting example of a tandem gene duplication in Arabidopsis, helps to explain the range of embryo phenotypes found in Arabidopsis mutants disrupted in essential chloroplast functions, addresses the nature of essential proteins encoded by the chloroplast genome, and underscores the value of using natural variation to study the relationship between chloroplast translation, plant metabolism, protein import, and plant development.
Consumers’ evolving definition and expectations for local foods
Authors: Lang Mark , Stanton John , Qu Yingdao 
Published: October 2014

Purpose
– Although locally sourced and produced foods are a growing trend in food marketing, they are not yet clearly understood nor consistently defined. There is no lack of definitions currently offered, however, based on expanding, evolving, and sometimes conflicting, dimensions. The purpose of this paper is to investigate various emerging definitional elements of local foods to determine which elements may be as important to food shoppers today as the prevailing food miles definition.

Design/methodology/approach
– A shopper survey is fielded and repeated measures ANOVA conducted to measure the relative importance of various definitional elements, assess where shoppers expect to acquire local foods, the price premium they are willing to pay, and differences that may exist across customer groups.

Findings
– The study finds that consumers do consider other definitional elements as important as distance in their definition of local foods and they expect to find them in secondary outlets beyond farmers markets and the produce department. Consumers are willing to pay a price premium and there are differences across light, medium, and heavy users.

Practical implications
– This study provides researchers with an expanded and clearer definition of local foods for future research and practitioners with guidance on what shoppers expect and value today and how to better source, merchandise, and promote local foods.

Originality/value
– By combining definitional elements from across industry, government, and academia and analyzing them together, this study offers a more comprehensive definition of local foods and consumer expectations.
Indie media and digital community collaborations in public libraries
Authors: Pecoskie Jen , L. Hill Heather 
Published: October 2014

Purpose
– This paper aims to examine the current state of collecting with emphasis on small, independent and local digital media for the purpose of exploring librarians’ tools to develop unique collections with these types of cultural products included.

Design/methodology/approach
– This conceptual paper is based on examination of the current state of publishing and digital media, of case profiles of independent digital content providers, of case profiles of public libraries using digital media to expand collections and of collection developers’ tools, including reviewing sources.

Findings
– With regard to expanding collections from small, independent and local digital content providers, user-generated content (UGC) is offered as a tool for collection developers to use alongside other traditional reviewing sources. UGC allows for embedding collective voices into collection development practices to capture digital cultural products from these providers.

Originality/value
– This paper reflects on the current state of digital content creation and publishing, including the limitations and possibilities in place for the future of public library collections from both large publishing companies and smaller media creators. Non-traditional digital media are cultural products produced for consumption and reception; therefore, we consider how these materials fit into contemporary collections, how they are connected to public libraries and subsequently are made available to library users.
Curating print collections in the digital age
Authors: Swanick Sean , Garland Jennifer 
Published: October 2014

Purpose
– Purpose: As collection development in research libraries becomes increasingly homogeneous and “e-preferred”, it is our heritage collections that differentiate us and anchor the physical presence of our institutions. These valuable heritage resources, vital for teaching, researching, and learning are unfortunately too often inaccessible, uncatalogued, and ultimately undiscoverable. This paper focuses on the curation of special collections as a means of exposing hidden collections and discusses practical steps undertaken to highlight unique print materials in the digital age.

Design/methodology/approach
– This case study describes the transformation of a hidden collection into a teaching collection through the exhibition of uncatalogued Islamic manuscripts, their associated digital component and the resulting faculty–librarian collaboration.

Findings
– By sharing print collections through exhibitions with an associated digital component, we are both increasing the visibility of, and improving access to the material.

Originality/value
– This case study outlines a successful approach to exposing hidden collections to support an innovative teaching and learning environment.
Selection biases that emerge when age meets gender
Authors: N. Ruggs Enrica , R. Hebl Michelle , Singletary Walker Sarah , Fa-Kaji Naomi 
Published: October 2014

Purpose– The purpose of this paper is to examine the interactive effects of gender and age on evaluations of job applicants. Given the double jeopardy hypothesis, the authors might anticipate that older women would be denigrated most in hiring evaluations. However, given expectations of normative gender behavior, the authors might anticipate that older men would be penalized most for not already having stable employment. This study aims to examine which hypothesis best describes selection biases based on age and gender.Design/methodology/approach– Stimuli depicting male and female job applicants at the various ages were developed. The stimuli were standardized by collecting facial photos of older White men and women at ages 20, 40, and 60, and morphing these faces onto standardized bodies using Adobe Photoshop. Participants viewed six stimuli, one from each age by gender combination, and made evaluations across job relevant dimensions.Findings– Results showed an interaction between age and gender, such that older male applicants were evaluated more negatively than older female and younger male applicants. These findings support for the violation of gender normative behavior hypothesis.Practical implications– This study has implications for organizational leaders who can use this information to provide training for selection officers concerning biases against older workers and how to avoid them.Originality/value– Original, novel stimuli are used in an experimental design to examine the effects of age in employment in a standardized manner which controls for extraneous variables such as attractiveness across age.
How asymmetrical task dependence and task interdependence interact
Authors: B. de Jong Simon , Matthijs Bal P. 
Published: October 2014

Purpose– The purpose of this paper is to investigate whether research and practice on task design and work teams could benefit from a more nuanced perspective on task (inter)dependencies among team members. Prior research often overlooked that task interdependence captures the average exchange of resources, while asymmetrical task dependence captures the inequalities within an individual's work relationships. To date, no study on work teams has combined the two aspects.Design/methodology/approach– Data were obtained from 262 individuals working in 67 work teams. Multilevel and bootstrapping analyses were used.Findings– Drawing from interdependence theory and power-dependence theory it was argued, and subsequently found, that asymmetrical task dependence interacts with task interdependence, and affects the job satisfaction of individuals and their affective commitment to their team.Practical implications– A key practical implication is that both asymmetrical task dependence and task interdependence should be taken into account when optimizing intra-team task dependencies, for instance when (re-)designing jobs or teams.Originality/value– This study contributes to research on asymmetrical task dependence within work teams, by investigating its interaction with task interdependence, its effects on the affective reactions of workers, and its effects on the individual level of analysis.
SEC administrative law judge bars investment manager for misrepresenting GIPS compliance
Authors: S. Caccese Michael , Y. Charton Douglas , A. Grossetti Pamela 
Published: October 2014

Purpose
– To explain an administrative law judge (ALJ) decision, along with a censure, fine, and industry disbarment, against an investment adviser for misleading advertising and false claims of compliance with Global Investment Performance Standards (GIPS).

Design/methodology/approach
– Explains the background to GIPS, the investment adviser’s GIPS violations, the significance of the case, and lessons to be learned by investment advisors on compliance with GIPS standards.

Findings
– The decision is particularly significant because the ALJ issued such severe sanctions based solely on false claims of GIPS compliance notwithstanding the fact that all reported performance returns were accurate and no investors relied on or were harmed by the false claims of compliance.

Practical implications
– The Zavanelli case should serve to put firms on notice that persistent noncompliance with the GIPS standards can have serious consequences and that all marketing materials should be subject to effective review and approval policies and procedures prior to distribution or publication to ensure compliance with the GIPS standards.

Originality/value
– Practical guidance from experienced financial services lawyers.
Customer experience from a self-service system perspective
Authors: Åkesson Maria , Edvardsson Bo , Tronvoll Bård 
Published: October 2014

Purpose
– A service system, including self-service technologies (SSTs), should facilitate actors’ value co-creation processes to enhance customer experiences. The purpose of this paper is to analyze how customers’ experiences – both favorable and unfavorable – are formed by identifying the underlying drivers when using SSTs in the context of a self-service-based system. The authors also analyze customers’ journeys, which occur before, during, and after their experience with a self-service-based system with SSTs.

Design/methodology/approach
– An exploratory, inductive study examines customers’ self-service experiences of using an SST. By undertaking 60 customer interviews, an event-based technique identified 200 favorable and unfavorable experienced events, which consist of activities and interactions identified through open coding guided by a theoretical framework. Customers’ experiences form through social norms and rules, referred to here as schemas. The authors sorted the drivers into four main categories of schemas (informational, relational, organizational, and technological) and into three categories: before, during, and after the store visit.

Findings
– The authors identified 13 favorable and unfavorable customer experience drivers that guide value co-creation and explain how the flow of value co-creation helps form customers’ experiences.

Research limitations/implications
– The results are limited to one self-service system context and therefore do not provide statistical generalizability. In addition, the examined company already focusses on customer experiences; other organizations may have different experience drivers.

Practical implications
– The results explain what is important when designing an SST-based service system. Besides, managers can promote the drivers in this research as advantages customers can gain by using self-service.

Originality/value
– This study offers original contributions by: first, classifying and analyzing 13 experience drivers in four categories grounded in customers’ schemas; and second, offering a new conceptualization that focusses on the formation of customers’ experiences during a value co-creation process – that is, the customer's journey – rather than on the outcome experience only.
Exploring key antecedents of purchase intentions within different services
Authors: Ha Hong-Youl , K. Akamavi Raphaël , J. Kitchen Phillip , Janda Swinder 
Published: October 2014

Purpose
– The purpose of this research is to investigate the direct and indirect effects of these determinants on purchase intentions. Competitive environments such as those in retail and banking industries impose increased pressure on managers to enhance customer satisfaction and purchase intentions. Even though satisfaction and purchase intentions are well studied in prior literature, their determinants such as service-oriented employee behavior, advertising campaign familiarity, physical environment and service quality have not been fully investigated together.

Design/methodology/approach
– Data from a survey of 508 customers of Korean up-market retail supermarkets and banks are utilized to empirically evaluate the model.

Findings
– Results indicate that service-oriented employee behavior and the physical environment have no direct effect on purchase intentions. However, these constructs indirectly influence purchase intentions through the mediating role of service quality and customer satisfaction. Service-oriented employee behaviors play a major role in enhancing service quality and customer satisfaction, but do not directly impact purchase intentions. Interestingly, the strongest direct effect on purchase intentions is more likely to come from service quality, rather than satisfaction.

Practical implications
– Findings suggest that for service industries such as retail and banking, it may be strategic to invest more resources aimed at enhancing service-oriented employee behaviors and the physical retail environment compared to advertising campaigns.

Originality/value
– Even though prior research has considered the concepts studied here, this study aims to empirically evaluate a variety of antecedent factors that potentially affect purchase intentions. Relationships are established utilizing data collected in South Korea (an increasingly important consumer market) which adds value to extant knowledge in this area.