bluuebunny/crossref_metadata_2025_split huggingface dataset:
tradução da oralidade de O Quinze para a língua francesa
Authors: Alves Maria Carolina de Brito 
Published: July 2024

Rachel de Queiroz publicou seu primeiro romance, "O Quinze", em 1930 e com ele alcançou notoriedade e visibilidade nacional. Sua linguagem simples e coloquial, repleta de marcas de oralidade, foi um ponto muito elogiado justamente por esboçar o falar do nordestino, do sertanejo, de forma natural e espontânea. Em 1986, "O Quinze" teve sua primeira versão publicada para a língua francesa, intitulada "L’année de la grande sécheresse" (tradução de Didier Voïta e Jane Lessa), e mais tarde, em 2014, uma nova tradução surge com o título "La terre de la grande soif" (tradução de Paula Anacaona). Sabendo que traduzir é acima de tudo uma tarefa desafiadora, esse artigo faz uma análise de como as marcas de oralidade, moldadas por Queiroz, foram transpostas para a língua francesa. Verificaremos se essas marcas, presentes no texto fonte foram respeitadas e de que forma as traduções mantiveram esse traço na língua de chegada. O embasamento teórico dessa pesquisa é feito através dos estudos de Paulo Henriques Britto (2016) sobre tradução literária, além de outros estudiosos.
Micro‐Chemical Plants
Authors: Serra Christophe A. , Parida Dambarudhar , Bally Florence , Garg Dhiraj K. , Hoarau Yannick , Hessel Volker 
Published: September 2013

Abstract
In this article, different microchemical plants for the synthesis of polymers and copolymers composed of microdevices are described and commented. Owing to their unique characteristics, microdevices allow rapid heat removal and mixing. This significantly improves the control over the polymerization by reducing or eliminating mass transfer limitations and hot spot formation. As a consequence, macromolecules with better controlled characteristics (eg, specific molecular weights and narrower molecular weight distributions), compositions, and architectures are obtained. Most common microdevices include microchannel‐based and microtubular reactors used for heat‐sensitive reactions.
Micromixers are also an important class of microdevices from which polymerization processes sensitive to reactant mixing can benefit. The typical few milliseconds mixing achieved in these micromixers, facilitating a fast and efficient temperature control, together with the easy operation at high temperatures (and pressures) allow for new operating process windows (eg, high temperatures combined with short reaction times, higher reactant concentrations) and selective reaction pathways. Thus microdevices can produce higher yields and selectivity than batch technologies. Therefore, these microdevices are the element of choice in the intensification of polymerization processes with the hope to be implemented for chemical production after scaling‐out. In addition, microdevices are also useful tools for high throughput experiments to generate a number of (co)polymers and to rapidly assess the influence of different process parameters.
Atherosclerotic Cardiovascular Disease in Hospitalized Patients With Systemic Sclerosis: Higher Mortality Than Patients With Lupus and Rheumatoid Arthritis
Authors: Dave Amish J. , Fiorentino David , Lingala Bharathi , Krishnan Eswar , Chung Lorinda 
Published: September 2013

ObjectiveSystemic sclerosis (SSc; scleroderma) patients have an increased risk for atherosclerotic cardiovascular disease (ASCVD), possibly mediated through inflammatory and fibrotic mechanisms affecting the macrovasculature and microvasculature. We utilized the US Nationwide Inpatient Sample to assess the frequency of and mortality risk associated with ASCVD among hospitalized SSc patients.MethodsWe examined the frequency and mortality associated with primary diagnoses and procedures related to ASCVD among adult SSc patients using data from 1993 to 2007. Using multivariate logistic regression (controlling for age, sex, nonelective admission, and modified Charlson Comorbidity Index), we compared the odds of death among hospitalized SSc patients with ASCVD to those with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA), as well as to a control group that excluded patients with connective tissue diseases.ResultsA total of 308,452 hospitalizations of SSc patients were included, of which 5.4% were associated with a primary ASCVD diagnosis or procedure. ASCVD‐related SSc hospitalizations were more likely to result in death compared with non‐ASCVD SSc hospitalizations (odds ratio [OR] 1.3, 95% confidence interval [95% CI] 1.1–1.4). Multivariate analyses showed that ASCVD‐related SSc hospitalizations were more likely to result in death than similar hospitalizations of SLE (OR 1.5, 95% CI 1.2–1.8), RA (OR 2.3, 95% CI 1.9–2.8), and control patients (OR 1.4, 95% CI 1.2–1.8) with ASCVD.ConclusionsSSc patients with ASCVD have higher in‐hospital mortality than comparable groups of SLE and RA patients with ASCVD. Further research to elucidate the specific mechanisms underlying ASCVD in SSc is necessary.
Pilot Study of Reproductive Health Counseling in a Pediatric Rheumatology Clinic
Authors: Ronis Tova , Frankovich Jennifer , Yen Sophia , Sandborg Christy , Chira Peter 
Published: September 2013

ObjectiveTo assess perception and behavior after reproductive health counseling among adolescent patients in a tertiary care–based pediatric rheumatology clinic.MethodsAdolescent females seen at a Stanford pediatric rheumatology clinic were prospectively enrolled during routine visits. At the study start, standard clinic procedures were reviewed with providers for the following: 1) the home, education, activities, drugs, sexual activity, and suicide/depression (HEADSS) assessment; 2) reproductive health counseling; and 3) medical record documentation. Patients were enrolled if providers indicated that they performed the HEADSS assessment and reproductive health counseling. At enrollment, patients completed a survey to assess their perceptions of reproductive health counseling. Chart reviews confirmed documented discussions. A followup survey performed 3–5 months after enrollment tracked reproductive health information–seeking behavior.ResultsIn total, 90 females (mean ± SD age 17 ± 2 years) participated. Almost all patients (99%) agreed that reproductive health was discussed; 71% reported that pregnancy risks were discussed, 42% had recent concerns about reproductive health, and 33% reported their provider recommended that they seek further reproductive health care. Eighty‐four patients completed followup phone surveys, with 25% reporting seeking further information on reproductive health concerns, but with only 9.5% actually seeking further care. Only 18% of patients reported having ever asked their rheumatology provider for guidance regarding reproductive health care concerns.ConclusionRoutine reproductive health discussion and counseling are necessary in a rheumatology clinic because, in our experience, a substantial number of adolescents have concerns and actively seek reproductive health information. Despite these discussions, adolescents rarely pursue further reproductive health care. Further work to bridge this gap is needed.
Psychometric Properties of the Foot and Ankle Outcome Score in a Community‐Based Study of Adults With and Without Osteoarthritis
Authors: Golightly Yvonne M. , DeVellis Robert F. , Nelson Amanda E. , Hannan Marian T. , Lohmander L. Stefan , Renner Jordan B. , Jordan Joanne M. 
Published: September 2013

ObjectiveFoot and ankle problems are common in adults, and large observational studies are needed to advance our understanding of the etiology and impact of these conditions. Valid and reliable measures of foot and ankle symptoms and physical function are necessary for this research. This study examined psychometric properties of the Foot and Ankle Outcome Score (FAOS) subscales (pain, other symptoms, activities of daily living [ADL], sport and recreational function [sport/recreation], and foot‐ and ankle‐related quality of life [QOL]) in a large, community‐based sample of African American and white men and women ages ≥50 years.MethodsJohnston County Osteoarthritis Project participants (n = 1,670) completed the 42‐item FAOS (mean age 69 years, 68% women, 31% African American, mean body mass index [BMI] 31.5 kg/m2). Internal consistency, test–retest reliability, convergent validity, and structural validity of each subscale were examined for the sample and for subgroups according to race, sex, age, BMI, presence of knee or hip osteoarthritis, and presence of knee, hip, or low back symptoms.ResultsFor the sample and each subgroup, Cronbach's alpha coefficients ranged from 0.95–0.97 (pain), 0.97–0.98 (ADL), 0.94–0.96 (sport/recreation), 0.89–0.92 (QOL), and 0.72–0.82 (symptoms). Correlation coefficients ranged from 0.24–0.52 for pain and symptoms subscales with foot and ankle symptoms and from 0.30–0.55 for ADL and sport/recreation subscales with the Western Ontario and McMaster Universities Osteoarthritis Index function subscale. Intraclass correlation coefficients for test–retest reliability ranged from 0.63–0.81. Items loaded on a single factor for each subscale except symptoms (2 factors).ConclusionThe FAOS exhibited sufficient reliability and validity in this large cohort study.
Autoantibodies to RuvBL1 and RuvBL2: A Novel Systemic Sclerosis–Related Antibody Associated With Diffuse Cutaneous and Skeletal Muscle Involvement
Authors: Kaji Kenzou , Fertig Noreen , Medsger Thomas A. , Satoh Takashi , Hoshino Kana , Hamaguchi Yasuhito , Hasegawa Minoru , Lucas Mary , Schnure Andrew , Ogawa Fumihide , Sato Shinichi , Takehara Kazuhiko , Fujimoto Manabu , Kuwana Masataka 
Published: September 2013

ObjectiveTo identify and characterize a novel systemic sclerosis (SSc)–related autoantibody directed against a complex consisting of RuvBL1 and RuvBL2 (RuvBL1/2) and to assess its clinical correlations.MethodsWe first analyzed 316 consecutive patients with SSc who were evaluated at Kanazawa University Hospital. Controls included 290 patients with other connective tissue diseases, interstitial lung disease alone, or autoimmune hepatitis, and 50 healthy subjects. Autoantibody specificities were analyzed using RNA and protein immunoprecipitation assays. Autoimmune targets were affinity purified using patients' sera and subjected to liquid chromatography mass spectrometry. SSc patients in another institution in Japan and the University of Pittsburgh cohort were also included in analysis for evaluating clinical correlations.ResultsBy protein immunoprecipitation assay, 6 SSc sera (1.9%) reacted with doublets with molecular weights of ∼50 kd. Liquid chromatography mass spectrometry of the partially purified autoantigen and additional immunoblot‐based analyses revealed that this antibody specificity recognized RuvBL1/2. Anti‐RuvBL1/2 antibody was exclusively detected in SSc patients. SSc patients with anti‐RuvBL1/2 in both the Japanese and Pittsburgh cohorts consistently had higher frequencies of SSc in overlap with myositis and diffuse skin thickening than those without anti‐RuvBL1/2. Compared with other autoantibodies related to SSc/myositis overlap (anti–PM‐Scl and anti‐Ku), anti‐RuvBL1/2 was distinctive in terms of its associations with older age at SSc onset, male sex, and a high frequency of diffuse cutaneous involvement.ConclusionAnti‐RuvBL1/2 antibody is a novel SSc‐related autoantibody associated with a unique combination of clinical features, including myositis overlap and diffuse cutaneous involvement.
Strong Association of Health Literacy With Functional Status Among Rheumatoid Arthritis Patients: A Cross‐Sectional Study
Authors: Caplan Liron , Wolfe Frederick , Michaud Kaleb , Quinzanos Itziar , Hirsh Joel M. 
Published: September 2013

ObjectiveStudies linking health literacy to outcomes in rheumatoid arthritis (RA) have been underpowered and have not adequately accounted for confounders. We examined the association of health literacy with functional status in 6,052 subjects participating in a prospective observational study, controlling for numerous important covariates.MethodsUsing linear regression, we analyzed the cross‐sectional association of health literacy, as measured by 2 validated single‐item literacy screening questions (SILS1 and SILS2), and functional status, assessed by the Health Assessment Questionnaire (HAQ) disability index. Subjects reported demographics, comorbidities, social support, educational attainment, visual problems, and memory problems, as well as use of prednisone, disease‐modifying antirheumatic drugs, and biologic agents. Each SILS measure was forced into the final model.ResultsLow health literacy was present in 7.0% and 4.3% of subjects (per SILS1 and SILS2, respectively). When controlling for all covariates, low health literacy was associated with a 0.376‐point greater HAQ score, compared to subjects with adequate health literacy (95% confidence interval 0.306, 0.447; P < 0.001). This relationship persisted, even after modeling educational attainment. Results were similar for the 2 SILS instruments. Low health literacy was also associated with poorer self‐reported adherence to RA medications. Visual and memory problems were associated with worse functional status.ConclusionHealth literacy was more strongly associated with functional status than prednisone use, smoking history, and biologic agent use, and independent of educational attainment. Health literacy may play an important role in understanding functional status in RA patients. Single‐item questions amenable to use in the clinical setting may identify subjects with low health literacy, who are at risk for poor RA outcomes.
Social Economic Costs and Health‐Related Quality of Life in Patients With Systemic Sclerosis in Spain
Authors: López‐Bastida Julio , Linertová Renata , Oliva‐Moreno Juan , Posada‐de‐la‐Paz Manuel , Serrano‐Aguilar Pedro 
Published: September 2013

ObjectiveCost‐of‐illness analysis is the main method of providing an overall vision of the economic impact of a disease. Such studies have been used to set priorities for health care policies and inform resource allocation. The aim of this study was to determine the economic burden from a societal perspective and health‐related quality of life (HRQOL) of patients with systemic sclerosis (SSc; scleroderma) in Spain.MethodsWe conducted a cross‐sectional, retrospective study of 147 patients with SSc. Data on demographic characteristics, health resource utilization, informal care, labor productivity losses, and HRQOL were collected from the questionnaires completed by patients or their caregivers. HRQOL was measured with the EuroQol 5‐domain (EQ‐5D) questionnaire.ResultsThe average annual cost for an SSc patient was 荤21,042; the reference year for unit prices was 2011. Direct health care costs amounted to 荤8,235, direct non–health care costs were 荤5,503, and loss of labor productivity was 荤7,303. The largest expenditures were early retirement, informal care, and medication. There are sharp differences in the estimated cost according to the Barthel Index score observed. The mean EQ‐5D score for SSc patients was 0.68 and the mean EQ‐5D visual analog scale score was 64.ConclusionThe main strengths of this study lie in our bottom‐up approach to costing and in the evaluation of SSc patients from a broad perspective (societal costs). This type of analysis is very scarce in international literature for rare diseases in comparison with other illnesses. We conclude that SSc patients incur considerable societal costs and experience substantial deterioration in HRQOL.
Suboptimal Inhibition of Platelet Cyclooxygenase 1 by Aspirin in Systemic Lupus Erythematosus: Association With Metabolic Syndrome
Authors: Kawai Vivian K. , Avalos Ingrid , Oeser Annette , Oates John A. , Milne Ginger L. , Solus Joseph F. , Chung Cecilia P. , Stein C. Michael 
Published: September 2013

ObjectiveLow‐dose aspirin prevents platelet aggregation by suppressing thromboxane A2 (TXA2) synthesis. However, in some individuals TXA2 suppression by aspirin is impaired, indicating suboptimal inhibition of platelet cyclooxygenase 1 (COX‐1) by aspirin. Because patients with systemic lupus erythematosus (SLE) have increased risk of thrombotic events, many receive aspirin; however, the efficacy of aspirin in SLE has not been determined. We examined the hypothesis that aspirin response is impaired in SLE.MethodsWe assessed the effect of aspirin by measuring concentrations of the stable metabolite of TXA2, serum thromboxane B2 (sTXB2), before and after treatment with daily aspirin (81 mg) for 7 days in 34 patients with SLE and 36 control subjects. The inability to suppress sTXB2 synthesis to <10 ng/ml represents suboptimal inhibition of platelet COX‐1 by aspirin.ResultsAspirin almost completely suppressed sTXB2 in control subjects to median 1.5 ng/ml (interquartile range [IQR] 0.8–2.7) but had less effect in patients with SLE (median 3.1 ng/ml [IQR 2.2–5.3]) (P = 0.002). A suboptimal effect of aspirin was present in 15% (5 of 34) of the patients with SLE but not in control subjects (0 of 36) (P = 0.023). Incomplete responders were more likely to have metabolic syndrome (P = 0.048), obesity (P = 0.048), and higher concentrations of C‐reactive protein (CRP) (P = 0.018).ConclusionThe pharmacologic effect of aspirin is suboptimal in 15% of patients with SLE but in none of the control subjects, and the suboptimal response was associated with metabolic syndrome, obesity, and higher CRP concentrations.
Progressive Macromolecular Self‐Assembly: From Biomimetic Chemistry to Bio‐Inspired Materials
Authors: Zhao Yu , Sakai Fuji , Su Lu , Liu Yijiang , Wei Kongchang , Chen Guosong , Jiang Ming 
Published: September 2013

AbstractMacromolecular self‐assembly (MSA) has been an active and fruitful research field since the 1980s, especially in this new century, which is promoted by the remarkable developments in controlled radical polymerization in polymer chemistry, etc. and driven by the demands in bio‐related investigations and applications. In this review, we try to summarize the trends and recent progress in MSA in relation to biomimetic chemistry and bio‐inspired materials. Our paper covers representative achievements in the fabrication of artificial building blocks for life, cell‐inspired biomimetic materials, and macromolecular assemblies mimicking the functions of natural materials and their applications. It is true that the current status of the deliberately designed and obtained nano‐objects based on MSA including a variety of micelles, multicompartment vesicles, and some hybrid and complex nano‐objects is at their very first stage to mimic nature, but significant and encouraging progress has been made in achieving a certain similarity in morphologies or properties to that of natural ones. Such achievements also demonstrate that MSA has played an important and irreplaceable role in the grand and long‐standing research of biomimetic and bio‐inspired materials, the future success of which depends on mutual and persistent efforts in polymer science, material science, supramolecular chemistry, and biology.
Hydrido‐Cobalt Catalyst as a Selective Tool for the Dimerisation of Arylacetylenes: Scope and Theoretical Studies
Authors: Ventre Sandrine , Derat Etienne , Amatore Muriel , Aubert Corinne , Petit Marc 
Published: September 2013

AbstractA simple hydrido‐cobalt complex efficiently catalyses the highly regio‐ and stereoselective dimerisation of various terminal arylacetylenes under mild conditions. The corresponding (E)‐1,4‐enynes are obtained as sole isomers with good to excellent yields. DFT calculations revealed that the reaction proceeds via a CH activation/hydrocobaltation pathway.magnified image
Cross validation of ROC generated thresholds for field assessed aerobic fitness related to weight status and cardiovascular disease risk in portuguese young people
Authors: Duncan Michael J. , Vale Susana , Santos Maria Paula , Ribeiro José Carlos , Mota Jorge 
Published: September 2013

ObjectivesTo examine the efficacy of aerobic fitness thresholds in predicting weight status and cardiovascular disease risk (CVD) in young people.MethodsA cross‐sectional school‐based study was conducted on 414 Portuguese young people (235 girls and 179 boys) aged 10–16 years (Mean age ± SD = 13.6 ± 1. 8 years). Height and mass were assessed to determine body mass index (BMI). The 20m multistage shuttle‐fitness test (MSFT) was used as an estimate of aerobic fitness. Capillary blood sampling was used to determine: total cholesterol, triglycerides, high‐, and low‐density lipoprotein. These were combined with measures of systolic blood pressure as z‐scores and summed to create a CVD risk score.ResultsAnalysis of covariance, controlling for sexual maturation, indicated a significant main effect for BMI as a result of fitness category (P = 0.0001). When applied to CVD risk data, there was no difference between “fit” and “unfit” grioups (P = 0.136). Subsequent receiver operating curve (ROC) analysis indicated signifciant diagnostic accuracy of 20mMSFT performance for boys and girls (both P = 0.0001) with subsequent cut‐offs of estimated VO2 peak of 49.5 ml kg−1 min−1 for girls and 47.7 ml kg−1 min−1 for boys. When applied to BMI and CVD risk data, there was a significant main effect as a result of fitness category for BMI (P = 0.0001) and CVD risk score (P = 0.0001).ConclusionsRecently established cut‐points proposed by Boddy et al. (Boddy et al. [2012]: PLoS One 7(9): e45755) show validity in distinguishing between weight status but not CVD risk in Portuguese young people. Alternative ROC generated cut points significantly predicted BMI and CVD risk in this sample. Am. J. Hum. Biol. 25:751–755, 2013. © 2013 Wiley Periodicals, Inc.
Adipose tissue: Another target organ for lead accumulation? A study on sardinian children (Italy)
Authors: Vallascas Elisabetta , De Micco Alessandro , Deiana Fabrizio , Banni Sebastiano , Sanna Emanuele 
Published: September 2013

ObjectivesThis study analyzes the relationship between lead levels and adipose tissue in Sardinian children. As an environmental pollutant, lead occurs in two different chemical forms: inorganic and organic lead; organic lead is present in the environment mainly as lead‐alkyls (tetramethyl and tetraethyl lead). The lead‐alkyls are characterized by their liposolubility; because of this characteristic, the behavior of organic Pb in the organism is similar to that of persistent organic pollutants (POPs). In fact, the high liposolubility of POPs, synthetic chemical substances highly resistant to biodegradation in both the environment and the human body, gives them a preferential tendency to accumulate in adipose tissue.MethodsThe study sample consisted of 759 children between 11 and 15 years resident in various municipalities of Sardinia. Hair lead levels (PbH) were used as the biomarker of exposure, while several anthropometric indexes were adopted to evaluate the adipose tissue: weight, body mass index, waist circumference, waist to hip circumference ratio, and sum of skinfolds (Σskf).ResultsThe results of the multivariate ridge regression analysis, controlling for sex and age, show a significant positive relationship between logPbH and logΣskf but not the other adiposity indicators.ConclusionsThis results suggests that organic lead tends to accumulate in adipose tissue, although it would be appropriate to measure lead levels in the adipose tissue itself in order to verify the results. Hence this tissue could be considered a possible new biological matrix for the evaluation of environmental lead exposure. Am. J. Hum. Biol. 25:789–794, 2013. © 2013 Wiley Periodicals, Inc.