bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonspecific Cell‐Mediated Immunity in Patients with Epidermodysplasia Verruciformis
Authors: de Oliveira Walmar Roncalli Pereira , Carrasco Solange , Neto Cyro Festa , Rady Peter , Tyring Stephen K. 
Published: July 2014

AbstractEpidermodysplasia verruciformis (EV) is a rare disease that usually begins in childhood and is characterized by a generalized infection by human papilloma virus (HPV), frequent associations with cutaneous carcinomas, and abnormalities of cell‐mediated immunity (CMI). We studied nonspecific CMI in 13 patients with EV by bacterial skin tests, allergic reactions to dinitrochlorobenzene (DNCB), measurement of responses to phytohemagglutinin (PHA), and quantification of T lymphocytes and T lymphocytes subsets in peripheral blood. Impairment of CMI was manifested by the cutaneous anergy to a variety of common skin antigens and, by the reduction of the lymphocyte transformation to PHA. There were no correlation between the severity of cases and abnormalities of CMI in our patients, however; the impairment of CMI was lower in cases of short duration, suggesting that the impairment of CMI in EV might reflect a long period of disease.
Epidermolysis Bullosa Acquisita in Childhood
Authors: Trigo‐Guzmán Fanny X. , Conti Adriana , Aoki Valéria , Maruta Celina W. , Santi Cláudia G. , Silva Claudia M. Resende , Gontijo Bernardo , Woodley David T. , Rivitti Evandro A. 
Published: July 2014

AbstractEpidermolysis bullosa acquisita (EBA) is a subepidermal autoimmune blistering disease that is rarely reported in childhood. We describe a nine‐month‐old mulatto boy presenting with multiple, annular, widespread, tense blisters and oral lesions. The diagnosis of EBA was confirmed by histopathology, immunofluorescence, and immunoblotting analysis. The patient was successfully treated with systemic steroids (prednisone) and dapsone. After 20 months of initial treatment, clinical remission was observed, and dapsone remains as the current treatment. This case report emphasizes the rarity of EBA in childhood and the difficulties in reaching the final diagnosis.
Circulating CD14+ CD16+ Monocytes Are Expanded in Sarcoidosis Patients
Authors: Okamoto Hiroyuki , Mizuno Kana , Horio Takeshi 
Published: July 2014

AbstractSarcoidosis is a systemic disease of unknown etiology characterized by noncaseating granulomas, consisting mainly of epithelioid cells and multinucleated giant cells derived from monocyte‐macrophage lineage cells. Monocytes fall into subpopulations comprising CD14++ CD16−, and CD14+ CD16+ cells, and expansion of the later monocytes has been reported under some pathological conditions. In this study, we examined the immunophenotype of blood monocytes in patients with sarcoidosis using two‐color immunofluorescence flow cytometry. In healthy controls CD14+ CD16+ monocytes account for 5.8 ± 2.8% of monocytes. The percentage of CD14+ CD16+ monocytes was significantly higher (p <0.02) in the sarcoidosis patients (11.8 ± 4.9%) compared with those in healthy control subjects. The serum ACE levels were significantly correlated with the percentage of CD14+ CD16+ monocytes (p <0.05). In contrast, the percentage was not correlated with purinergic receptor expression of monocytes as estimated by LDH release from BzATP‐stimulated monocytes. These findings suggest that CD14+ CD16+ monocytes represent a sensitive marker for the disease activity of sarcoidosis.
Basal Cell Carcinoma with Sarcomatoid Features (Sarcomatoid Carcinoma): Report of a Case and Review of the Literature
Authors: Gómez‐Espejo Carmen , Herrera‐Sabal Alberto , Ríos‐Martín Juan José , Camacho‐Martínez Francisco 
Published: July 2014

AbstractWe report a new case of sarcomatoid carcinoma, which showed cellular features of basal cell carcinoma and malignant fibrous myxoid histiocytoma. For this new case and rare neoplasm, we propose the designation of sarcomatoid basal cell carcinoma, as both components were intimately intermingled, the spindle cells seemed to arise from epithelial cells, and both tumoral components showed the same immunohistochemistry expression, cytokeratin and P53 protein, suggesting a monoclonal origin. The epithelial component, a basal cell carcinoma, may have been the first component in the carcinogenesis process.
Serum Levels of IL‐4, IL‐10, IL‐12, IL‐13 and IFN‐Gamma in Behçet's Disease
Authors: Aridogan Buket Cicioglu , Yildirim Mehmet , Baysal Vahide , Inaloz H. Serhat , Baz Kiymet , Kaya Selcuk 
Published: July 2014

AbstractBehçet's disease (BD) is an inflammatory disease of unknown etiology. Although its pathogenesis is not fully understood, recent studies have suggested that immunological abnormalities and neutrophil hyperfunction may be involved in its etiology and pathophysiology. The immune system in BD can be characterized as a divergent cytokine production profile of the mixed Th1/Th2 cell type. In this study, we investigated the levels of interleukin (IL)‐4, IL‐10, IL‐12, IL‐13 and interferon‐γ in the sera of patients with BD, in comparison with recurrent aphthous stomatitis and healthy controls, to determine the Th1/Th2 profile of the disease. The levels of IL‐4, IL‐10 and IL‐13 were found to be high in active BD patients, and IL‐12 and interferon‐γ levels were lower in active BD patients than in inactive BD, recurrent aphthous stomatitis, and control patients.
Three Cases of Malignant Melanoma Arising on Burn Scars
Authors: Kikuchi Hidezumi , Nishida Takaaki , Kurokawa Motoki , Setoyama Mitsuru , Kisanuki Atsushi 
Published: July 2014

AbstractIt is well known that up to 2% of chronic burn scar lesions can transform into malignant tumors. Most of them are squamous cell carcinoma (SCC) and, more occasionally, basal cell carcinoma (BCC). The incidence of malignant melanoma (MM) is extremely low. To the best of our knowledge, there are only 23 such cases reported in the literature. We report here three cases of MM arising on burn scars and analyze the 23 cases reported previously. Case 1: A 74‐year‐old Japanese man sustained a burn injury on about 54% of his whole body surface when he was accidentally bathed in boiling oil at the age of 37 years old. Some small tumors developed on the burn scar on his right lumbar region. A wide excision of the tumor was performed. Case 2: A 51‐year‐old Japanese woman was injured on her right forearm and face by deep burns from a flame when she was 7 months old. She presented with a rapidly growing, painless black nodule on the dark skin lesion on her right forearm. She was treated with a wide excision followed by a full‐thickness skin graft. Intravenous administration of one unit of OK‐432 every week has been continued. Case 3: A 73‐year‐old Japanese woman was burned on her left leg and hand from a flame when she was 6 years old. A nodular lesion appeared within the ulcer two months previously and it was growing rapidly. This lesion was ulcerated on the top of its central area and was slightly reddish without any pigmentation. The patient was treated with a wide excision and a split‐thickness skin graft. The 5‐year survival rate of MM in an old burn scar is 53.6%. It is suggested that the prognosis of burn scar carcinoma is not worse than that of non‐burn scar carcinoma.
The Expression of Melanogenic Proteins in Korean Skin after Ultraviolet Irradiation
Authors: Kim Tae Jin , Cho Moon Keun , Lee Jong Suk , Whang Kyu Uang , Jin So Young , Hoshino Taku 
Published: July 2014

AbstractFor proper melanin production, several specific enzymes such as tyrosinase, tyrosinase‐related protein 1 (TRP‐1) and dopachrome tautomerase are required. Their expressions are increased after exposure to UVB. However, it is not known how long tyrosinase and TRP‐1 activities continue after UV irradiation in vivo. The purpose of this study is to measure the changes in expressions of tyrosinase, TRP1, and MITF after exposure to UV on skin in a Korean population. We established an immunohistochemical staining protocol for specimens which were obtained from UV‐irradiated skin in five healthy Korean males on the 2nd, 5th, 7th, 28th, and 56th days after UV irradiation. Tyrosinase, TRP‐1, and MITF expressions increased until 7 days after UV irradiation and then dropped to the basal constitutive level 4 and 8 weeks later. Interestingly, tyrosinase increased prior to TRP‐1. This study reveals the time‐sequence of melanin‐synthesized enzymes and provides important information for the clinical evaluation of the effectiveness of whitening agents.
Immediate and Delayed Complications of Dexamethasone Cyclophosphamide Pulse (DCP) Therapy
Authors: Jain Rajesh , Kumar Bhushan 
Published: July 2014

AbstractDexamethasone‐cyclophosphamide pulse (DCP) is the prefered mode of therapy in pemphigus in India because it is relatively free from the side effects seen with heavy doses of daily oral steroids. One hundred forty‐six pemphigus patients treated with DCP were observed for side effects of this regimen. One hundred forty mg of dexamethasone was administered IV in 200 ml of 5% dextrose over a period of 60–90 minutes on 3 consecutive days. Five hundred mg of cyclophosphamide was added on first day of the pulse and 50 mg given orally daily in the intervening period. DCP was repeated every 4 weeks and continued for 6 months after subsidence of the disease (no new lesions). Flushing over the face was the most common event recorded during the adiministration in 78 subjects followed by palpitations in 11, hiccups in 9, and numbness of feet in 6. Fourteen patients had polyurea, and 3 developed skin rash. Shivering, shooting pains along thighs, breathlessness, seizure and unilateral limb edema were observed in one patient each. Generalized weakness/malaise was the most troublesome delayed side effect in 81 (55.4%) patients; it lasted for 8–15 days after the pulse. Thirty‐six (24.6%) had inadequate sleep syndrome, 23 (15.7%) had headache, 21 (14.3%) complained of arthralgias, 19 (13%) experienced alteration in taste, and 13 (9%) had diffuse hair loss. 28 females developed menstrual disturbances, and 14 (9.5%) had blurring of vision (glaucoma in 3 and posterior subcapsular cataract in 1). Thirteen of eighteen diabetics had an increase in blood sugar requiring higher doses of insulin. Five NIDDM patients needed insulin. Four (2.7%) developed hypertension. Pulse therapy is not absolutely free from side effects. Hypertension and diabetes occur less frequently as compared to conventional steroid therapy. Generalized weakness, flushing, headache and taste alteration occur exclusively with pulse therapy.
Successful Treatment of Multiple Premalignant and Malignant Lesions in Arsenical Keratosis with a Combination of Acitretin and Intralesional 5‐Fluorouracil
Authors: Khandpur Sujay , Sharma Vinod K. 
Published: July 2014

AbstractA case of arsenical keratosis with multiple lesions of Bowen's disease and squamous cell carcinoma is described. The patient was successfully treated with a combination of acitretin and intralesional 5‐fluorouracil. All the lesions resolved after three months of therapy with no side effects and no recurrence during four months of follow‐up.
Ultraviolet‐B Phototherapy Is Successful in Japanese Patients with Early‐Stage Mycosis Fungoides
Authors: Abe Masatoshi , Ohnishi Kazunori , Kan Chie , Ishikawa Osamu 
Published: July 2014

AbstractUVB phototherapy is widely used for the treatment of psoriasis and atopic dermatitis, however, only limited reports evaluate its usefulness in the treatment of mycosis fungoides. We introduced UVB phototherapy to five patients with early‐stage mycosis fungoides. All of them were classified as stage IB (erythematous stage), and none had obtained a satisfactory response to other therapies. After initial treatment with UVB phototherapy, all the patients obtained significant improvement in their skin lesions leaving pigmentary changes. After this satisfactory response was achieved, the same dose of UVB was administrated as a maintenance therapy with longer intervals between exposures. Histopathological examination of three patients revealed decreased numbers of inflammatory cells in both the epidermis and the dermis after the treatment. Immunohistochemical study showed that CD1a+/HLA‐DR+ dendritic cells were present throughout the lesional epidermis before the treatment. In contrast, after the treatment, the dendritic cells in the epidermis were CD1a+/HLA‐DR−. Although it remains unclear why only the expression of HLA‐DR antigen was eliminated after treatment, we presume that this loss of HLA‐DR antigen expression by epidermal Langerhans cells was, in part, responsible for the improvement of skin lesions. This preliminary study suggests that UVB phototherapy is an effective treatment for patients with early‐stage mycosis fungoides.
The Successful Use of Topical Tacrolimus Treatment for a Chronic Actinic Dermatitis Patient with Complications of Idiopathic Leukopenia
Authors: Ogawa Yasushi , Adachi Ayumi , Tomita Yasushi 
Published: July 2014

AbstractChronic actinic dermatitis (CAD) is a photosensitivity disorder marked by severe eczematous lesions on exposed areas. Although associations with contact dermatitis, atopic dermatitis, and human immunodeficiency virus (HIV) have been suggested, its pathogenesis remains unknown. CAD is often refractory, and systemic administration of cyclosporin A has been the treatment of choice. Recently, topical tacrolimus therapy has been reported to be effective. We report the efficacy of topical tacrolimus treatment in a CAD patient who also had the complication of idiopathic leukopenia. A phototest showed marked suppression of erythema formation in the skin pre‐treated with tacrolimus before UVB radiation but not in the skin treated after the irradiation. Therefore, it is suggested that tacrolimus may prevent UV‐B induced erythema by suppressing a very early phase of the inflammatory process in CAD.
X‐Linked Dominant Inheritance in Palmoplantar Keratoderma with Leukokeratosis: A Study of the Pedigree of Two Cases
Authors: Sharma Prafulla Kumar , Rath Namita , Chauhan Ruchi , Sharma Suresh Kumar , Kar Hemant Kumar 
Published: July 2014

AbstractKeratoderma of the palms and soles is not of rare occurrence. Its association with leukokeratosis of the mouth is well recognized. We describe two siblings having callosities like keratoderma over the weight bearing areas of soles, pressure areas of palms and palmar creases with leukokeratosis of cheeks. On study of the pedigree of these probands we could trace the trait transmission by a rare X‐linked dominant mechanism.
Glomangiosarcoma of the Hand: A Case Report and Review of the Literature
Authors: Park Jung‐Hun , Oh Seok‐Hun , Yang Moon‐Ho , Kim Nack‐In 
Published: July 2014

AbstractGlomangiosarcomas, or malignant glomus tumors, are very rare, cutaneous, soft tissue tumors. Despite having histologic features of malignancy, these tumors usually do not metastasize. We describe a 74‐year‐old woman with a glomangiosarcoma on her hand and review the literature. The woman presented with a five month history of a painful mass on the right palm. An excisional biopsy of the mass was undertaken. Histologically, the tumor was composed of uniform, round cells and numerous vascular components. The tumor cells were pleomorphic and had large nucleoli. Frequent mitotic figures were identified. Immunohistochemical stains showed strong positivity for vimentin and weak, focal positivity for smooth muscle actin. Ultrastructurally, the tumor cells were characterized by pinocytic vesicles, well formed basal lamina, and scattered junctional complex of the plasma membrane.
Sphingosine May Have Cytotoxic Effects via Apoptosis on the Growth of Keloid Fibroblasts
Authors: Chang Sung‐Eun , Kim Kyoung‐Jin , Ro Kyoung‐Hyun , Lim Young‐Jin , Choi Jee‐Ho , Moon Kee‐Chan , Sung Kyung‐Jeh 
Published: July 2014

AbstractKeloids are often resistant to treatment, causing much suffering to the patient. Our previous work found that ceramide (Cer) inhibits growth of fibroblasts via apoptosis. However, when compared to normal fibroblasts (NFs), which are quiescent, keloid fibroblasts (KFs) rapidly proliferate and are reported to be resistant to apoptosis via Cer. Sphingosine (Sph) is a metabolite product of ceramide that has some different biochemical properties. Thereofore, we investigated the cytotoxic effects of Sph on cultured fibroblasts from keloid lesions and normal skin in order to evaluate the possibility of using Sph in the treatment of keloid. We used the lactic dehydrogenase (LDH) method, MTT method, and propidium iodide (PI) method. Sph had cytotoxic effects via apoptosis on both the KFs and NFs. Our results indicate that Sph may be applicable to the future treatment of keloid.
Brooke‐Spiegler Syndrome Associated with Cylindroma, Trichoepithelioma, Spiradenoma, and Syringoma
Authors: Uede Koji , Yamamoto Yuki , Furukawa Fukumi 
Published: July 2014

AbstractBrooke‐Spiegler syndrome is a rare, autosomally dominant disease characterized by the development of multiple cylindromas, trichoepitheliomas, and occasional spiradenomas. We report herein a case of Brooke‐Spiegler syndrome in a 55‐year‐old woman associated with multiple cylindromas, spiradenomas, trichoepitheliomas, and syringomas that developed on her face. Her 52‐year‐old sister also suffered from multiple trichoepitheliomas. Although there is variable clinical and histological expression in Brooke‐Spiegler syndrome, all of the tumors encountered in our case were related to folliculosebaceous‐apocrine units.
A Case of a Large Dermatofibrosarcoma Protuberans Successfully Treated with Radiofrequency Ablation and Transcatheter Arterial Embolization
Authors: Imai Yasutomo , Habe Koji , Imada Mika , Hakamada Arata , Isoda Ken‐ich , Yamanishi Kiyofumi , Uchida Atsumasa , Mizutani Hitoshi 
Published: July 2014

AbstractWe present a large dermatofibrosarcoma protuberans on a 52 years‐old woman's back that was successfully treated with transcatheter arterial embolization and radiofrequency ablation. The tumor developed on her back at the age of 14. Surgical treatment was not complete, and it relapsed at age 17 and again at age 24. The tumor enlarged to over 20 × 20 × 10 cm and flooded intermittently. The tumor cells with atypical nuclei were CD34 positive and proliferated in a storiform pattern. These findings were compatible with dermatofibrosarcoma protuberans. She was treated with blood transfusion for severe anemia. Two large feeding arteries were embolized, and the bottom of the tumor was treated with radiofrequency ablation. The tumor reduced in volume by more than 50%. It was then surgically removed and reconstructed with a free mesh skin graft. The combination pretreatment enabled radical resections of a large DFSP without severe complications.
Two Cases of Angiosarcoma of the Face
Authors: Kikuchi Hidezumi , Kurokawa Motoki , Setoyama Mitsuru 
Published: July 2014

AbstractAngiosarcoma is a rare vascular malignant tumor most commonly seen on the scalp of elderly people. We report here two cases of angiosarcoma of the face in 74‐ and 75‐year‐old males. It is very unusual to find the development of an angiosarcoma with a rosacea on the face. To the best of our knowledge, only three such cases have been reported.
T Cell Subpopulations and IL‐2R in Vitiligo
Authors: Gunduz Kamer , Ozturk Gunseli , Terzioglu Ender , Sebik Filiz 
Published: July 2014

AbstractImmunological alterations have been implicated in the etiopathogenesis of vitiligo. The aim of this study was to determine peripheral lymphocyte subpopulations and interleukin‐2 receptor (IL‐2R) in patients with vitiligo. Forty‐five vitiligo patients (24 female, 21 male) and 34 healthy controls (11 female, 23 male) were included into the study. Eight (17.8%) of the patients had the segmental type, and 37 (82.2%) had generalized vitiligo. The disease was active in 25 (55.6%) patients; the other 20 (44.4%) patients had static vitiligo. Flow cytometry was used to determine the percentages of total T‐lymphocytes, B‐lymphocytes, helper/inducer T cells, suppressor/cytotoxic T cells, natural killer (NK) cells, activated T cells and interleukin‐2 receptor (IL‐2R) with the use of CD3, CD19, CD4, CD8, CD16, HLA‐DR and CD25 monoclonal antibodies, respectively. The mean value of helper T cells showed a significant difference (p=0.01) between the two groups with the value being 32.5% in patients and 38.1% in control subjects. CD4/CD8 was significantly lower in vitiligo patients (p=0.04). There was also a statistically significant difference in the mean percentage of activated T cells between vitiligo patients and control subjects (4.7 and 8.1, respectively; p=0.001). No statistically significant differences were found when the values were compared between segmental and generalized vitiligo patients, or between active and static cases. In conclusion, T helper/inducer cells, CD4/CD8 ratio and activated (HLA‐DR+) T cells are decreased in vitiligo patients, suggesting a role for changes in cellular immunity.
Morbihan's Disease: Treatment with CO2 Laser Blepharoplasty
Authors: Bechara Falk Georges , Jansen Thomas , Losch Rüdiger , Altmeyer Peter , Hoffmann Klaus 
Published: July 2014

AbstractMorbihan's disease is a rare condition characterized by chronic persistent erythema and edema of the upper half of the face. Therapeutic regimens such as X‐ray irradiation, lymphatic massage, interferon gamma injections, antihistamines, and high‐dose antibiotics are often unsatisfactory. Promising results in some patients have been achieved by a systemic combination therapy of isotretinoin with ketotifen or clofazimine. Excision of redundant edematous tissue may be an alternative. We present a 67‐year‐old Caucasian patient with a two‐year history of right lower and upper eyelid swelling and erythema. Systemic therapies with corticocosteroids and antibiotics were not successful, but CO2 laser blepharoplasty led to good cosmetic results with marked improvement of visual impairment and no recurrence during the six‐month follow‐up period.
A Case of Multifocal Lupus Vulgaris that Preceded Pulmonary Tuberculosis in an Immune Compromised Patient
Authors: Hamada Manabu , Urabe Kazunori , Moroi Yoichi , Koga Tetsuya , Takeishi Masaaki , Fujita Masaki , Nakanishi Yoichi , Furue Masutaka 
Published: July 2014

AbstractWe describe the rare case of a Japanese male with multifocal lupus vulgaris that preceded asymptomatic pulmonary tuberculosis and adult T‐cell leukemia/lymphoma (ATL). He visited our hospital with multiple reddish plaques and erythema of 4–12 months duration. A skin biopsy revealed non‐caseating epithelioid granulomas. Mycobacterium tuberculosis was detected by polymerase chain reaction (PCR)‐hybridization from a skin biopsy specimen and was also isolated from a culture of the skin biopsy sample. The result of chest roentogenography was compatible with pulmonary tuberculosis. In addition, the diagnosis of ATL was based upon the presence of atypical lymphocytes with convoluted nuclei in his peripheral blood and a positive anti‐ATL antibody reaction. Cases of cutaneous tuberculosis presenting with unusual clinical features may be on the increase, accompanying the spread of tuberculosis in immunosuppressed patients, including those with ATL and acquired immunodeficiency syndrome (AIDS).