bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spatially Resolved Quantification of Gadolinium(III)‐Based Magnetic Resonance Agents in Tissue by MALDI Imaging Mass Spectrometry after In Vivo MRI
Authors: Aichler Michaela , Huber Katharina , Schilling Franz , Lohöfer Fabian , Kosanke Katja , Meier Reinhard , Rummeny Ernst J. , Walch Axel , Wildgruber Moritz 
Published: February 2015

AbstractGadolinium(III)‐based contrast agents improve the sensitivity and specificity of magnetic resonance imaging (MRI), especially when targeted contrast agents are applied. Because of nonlinear correlation between the contrast agent concentration in tissue and the MRI signal obtained in vivo, quantification of certain biological or pathophysiological processes by MRI remains a challenge. Up to now, no technology has been able to provide a spatially resolved quantification of MRI agents directly within the tissue, which would allow a more precise verification of in vivo imaging results. MALDI imaging mass spectrometry for spatially resolved in situ quantification of gadolinium(III) agents, in correlation to in vivo MRI, were evaluated. Enhanced kinetics of Gadofluorine M were determined dynamically over time in a mouse model of myocardial infarction. MALDI imaging was able to corroborate the in vivo imaging MRI signals and enabled in situ quantification of the gadolinium probe with high spatial resolution.
Radical CH Arylation of the BODIPY Core with Aryldiazonium Salts: Synthesis of Highly Fluorescent Red‐Shifted Dyes
Authors: Verbelen Bram , Boodts Stijn , Hofkens Johan , Boens Noël , Dehaen Wim 
Published: February 2015

AbstractWe describe herein the first radical CH arylation of BODIPY dyes. This novel, general, one‐step synthetic procedure uses ferrocene to generate aryl radical species from aryldiazonium salts and allows the straightforward synthesis of brightly fluorescent (Φ>0.85) 3,5‐diarylated and 3‐monoarylated boron dipyrrins in up to 86 % yield for a broad range of aryl substituents. In this way, new and complex dyes with red‐shifted spectra can be easily prepared.
Photoswitching the Cytotoxic Properties of Platinum(II) Compounds
Authors: Presa Andreu , Brissos Rosa F. , Caballero Ana Belén , Borilovic Ivana , Korrodi‐Gregório Luís , Pérez‐Tomás Ricardo , Roubeau Olivier , Gamez Patrick 
Published: February 2015

AbstractThe photoactivation of potential anticancer metal complexes is a hot topic of current research as it may lead to the development of more selective drugs. Photoactivated chemotherapy (PACT) with coordination compounds is usually based on a (photo)chemical reaction taking place at the metal center. Herein, a new strategy is exploited that consists of “photomodifying” a ligand coordinated to metal ions. Platinum(II) complexes from photoswitchable 1,2‐dithienylethene‐containing ligands have been prepared, which exhibit two interconvertible photoisomeric forms that present distinct DNA‐interacting properties and cytotoxic behaviors.
Effect of aliphatic diacyl adipic dihydrazides on the crystallization of poly(lactic acid)
Authors: Qi Zhongfei , Yang Yong , Xiong Zhu , Deng Jun , Zhang Ruoyu , Zhu Jin 
Published: February 2015

ABSTRACTA series of aliphatic diacyl adipic dihydrazides (ADHs) with different alkyl moieties were synthesized by the reaction between adipic dihydrazide and acyl chloride. Then these ADHs were solution blended with PLA respectively and were evaluated as nucleating agents. Through the investigation of nonisothermal and isothermal crystallization, it was found that both the crystallization rate and the crystallinity of PLA could be enhanced by adding only 1 wt % of ADHs. Especially for ADH‐Oc (ADH‐Octyl), the crystallization rate of PLA increased about 4 times at 105°C. Optical morphology showed that and the size of PLA spherulites decreased and the nucleation density increased with the existence of ADH‐Oc. Meanwhile, the crystal structure of PLA were not discerniblly affected after the addition of ADHs as found by wide‐angle X‐ray diffraction. Thus, this study suggested these ADHs compounds are simple and potential nucleating agents to enhance crystallization ability of PLA. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42028.
Influence of Intracellular Zinc on Cultures of Rat Cardiac Neural Crest Cells
Authors: Yang Hsunhui , Keen Carl L. , Lanoue Louise 
Published: February 2015

BACKGROUNDDevelopmental zinc (Zn) deficiency increases the incidence of heart anomalies in rat fetuses, in regions and structures derived from the outflow tract. Given that the development of the outflow tract requires the presence of cardiac neural crest cells (cNCC), we speculated that Zn deficiency selectively kills cNCC and could lead to heart malformations.METHODSCardiac NCC were isolated from E10.5 rat embryos and cultured in control media (CTRL), media containing 3 μM of the cell permeable metal chelator N, N, N′, N′‐tetrakis (2‐pyridylmethyl) ethylene diamine (TPEN), or in TPEN‐treated media supplemented with 3 μM Zn (TPEN + Zn). Cardiac NCC were collected after 6, 8, and 24 h of treatment to assess cell viability, proliferation, and apoptosis.RESULTSThe addition of TPEN to the culture media reduced free intracellular Zn pools and cell viability as assessed by low ATP production, compared to cells grown in control or Zn‐supplemented media. There was an accumulation of reactive oxygen species, a release of mitochondrial cytochrome c into the cytoplasm, and an increased cellular expression of active caspase‐3 in TPEN‐treated cNCC compared to cNCC cultured in CTRL or TPEN + Zn media.CONCLUSIONZn deficiency can result in oxidative stress in cNCC, and subsequent decreases in their population and metabolic activity. These data support the concept that Zn deficiency associated developmental heart defects may arise in part as a consequence of altered cNCC metabolism
PMCA4 (ATP2B4) mutation in familial spastic paraplegia causes delay in intracellular calcium extrusion
Authors: Ho Philip Wing‐Lok , Pang Shirley Yin‐Yu , Li Miaoxin , Tse Zero Ho‐Man , Kung Michelle Hiu‐Wai , Sham Pak‐Chung , Ho Shu‐Leong 
Published: February 2015

AbstractBackgroundFamilial spastic paraplegia (FSP) is a heterogeneous group of disorders characterized primarily by progressive lower limb spasticity and weakness. More than 50 disease loci have been described with different modes of inheritance. Recently, we described a novel missense mutation (c.803G>A, p.R268Q) in the plasma membrane calcium ATPase (PMCA4, or ATP2B4) gene in a Chinese family with autosomal dominant FSP. Further to this finding, here we describe the functional effect of this mutation.MethodsAs PMCA4 removes cytosolic calcium, we measured transient changes and the time‐dependent decay of cytosolic calcium level as visualized by using fura‐2 fluorescent dye with confocal microscopy in human SH‐SY5Y neuroblastoma cells overexpressing either wild‐type or R268Q mutant PMCA4.ResultsOverexpressing both wild‐type and R268Q PMCA4 significantly reduced maximum calcium surge after KCl‐induced depolarization as compared with vector control cells. However, cells overexpressing mutant PMCA4 protein demonstrated significantly higher level of calcium surge when compared with wild‐type. Furthermore, the steady‐state cytosolic calcium concentration in these mutant cells remained markedly higher than the wild‐type after SERCA inhibition by thapsigargin.ConclusionOur result showed that p.R268Q mutation in PMCA4 resulted in functional changes in calcium homeostasis in human neuronal cells. This suggests that calcium dysregulation may be associated with the pathogenesis of FSP.
Microbial Transglutaminase and c‐myc‐Tag: A Strong Couple for the Functionalization of Antibody‐Like Protein Scaffolds from Discovery Platforms
Authors: Dennler Patrick , Bailey Laura K. , Spycher Philipp R. , Schibli Roger , Fischer Eliane 
Published: February 2015

AbstractAntibody‐like proteins selected from discovery platforms are preferentially functionalized by site‐specific modification as this approach preserves the binding abilities and allows a side‐by‐side comparison of multiple conjugates. Here we present an enzymatic bioconjugation platform that targets the c‐myc‐tag peptide sequence (EQKLISEEDL) as a handle for the site‐specific modification of antibody‐like proteins. Microbial transglutaminase (MTGase) was exploited to form a stable isopeptide bond between the glutamine on the c‐myc‐tag and various primary‐amine‐functionalized substrates. We attached eight different functionalities to a c‐myc‐tagged antibody fragment and used these bioconjugates for downstream applications such as protein multimerization, immobilization on surfaces, fluorescence microscopy, fluorescence‐activated cell sorting, and in vivo nuclear imaging. The results demonstrate the versatility of our conjugation strategy for transforming a c‐myc‐tagged protein into any desired probe.
NAF‐1 antagonizes starvation‐induced autophagy through AMPK signaling pathway in cardiomyocytes
Authors: Du Xiaohong , Xiao Renjie , Xiao Fan , Chen Yong , Hua Fuzhou , Yu Shuchun , Xu Guohai 
Published: February 2015

AbstractNAF‐1 (nutrient‐deprivation autophagy factor‐1), an autophagy‐related gene‐related (ATG) protein, has been implicated in the autophagic pro‐survival response. However, its role in autophagy has not been examined in the cardiomyocytes. In this study, we found that nutritional stress (NS) induced by glucose deprivation strongly induced autophagy in cultured neonatal rat cardiomyocytes, which was associated with NAF‐1 down‐regulation in cardiomyocytes under NS conditions. Furthermore, we demonstrate that ectopic expression of NAF‐1 was sufficient to inhibit autophagy in cardiomyocytes under glucose deprivation conditions. Moreover, results of the co‐immunoprecipitation assay indicate that NAF‐1 antagonized autophagy by promoting the interaction between Beclin1 and Bcl‐2 in NS‐induced cardiomyocytes. Importantly, our results indicate that overexpression of NAF‐1 significantly inhibited AMPK activity and protected cardiomyocytes from NS‐induced cell death. Taken together, these data show that ectopic expression of NAF‐1 antagonizes the degree of autophagy in cardiomyocytes and enhances cell survival during starvation conditions.
Ultrasound‐ and Microwave‐Assisted Preparation of Lead‐Free Palladium Catalysts: Effects on the Kinetics of Diphenylacetylene Semi‐Hydrogenation
Authors: Wu Zhilin , Cherkasov Nikolay , Cravotto Giancarlo , Borretto Emily , Ibhadon Alex O. , Medlock Jonathan , Bonrath Werner 
Published: February 2015

AbstractThe effect of environmentally benign enabling technologies such as ultrasound and microwaves on the preparation of the lead‐free Pd catalyst has been studied. A one‐pot method of the catalyst preparation using ultrasound‐assisted dispersion of palladium acetate in the presence of the surfactant/capping agent and boehmite support produced the catalyst containing Pd nanoparticles and reduced the number of pores larger than 4 nm in the boehmite support. This catalyst demonstrated higher activity and selectivity. The comparison of kinetic parameters for diphenylacetylene hydrogenation showed that the catalyst obtained by using the one‐pot method was seven times as active as a commercial Lindlar catalyst and selectivity towards Z‐stilbene was high. Our work also illustrated that highly selective Pd/boehmite catalysts can be prepared through ultrasound‐assisted dispersion and microwave‐assisted reduction in water under hydrogen pressure without any surfactant.
Self‐Assembly and Gelation of Poly(aryl ether) Dendrons Containing Hydrazide Units: Factors Controlling the Formation of Helical Structures
Authors: Malakar Partha , Prasad Edamana 
Published: February 2015

AbstractSelf‐assembly of AB2 and AB3 type low molecular weight poly(aryl ether) dendrons that contain hydrazide units were used to investigate mechanistic aspects of helical structure formation during self‐assembly. The results suggest that there are three important aspects that control helical structure formation in such systems with acyl hydrazide/hydrazone linkage: i) J‐type aggregation, ii) the hydrogen‐bond donor/acceptor ability of the solvent, and iii) the dielectric constant of the solvent. The monomer units self‐assemble to form dimer structures through hydrogen‐bonding and further assembly of the hydrogen‐bonded dimers leads to macroscopic chirality in the present case. Dimer formation was confirmed by NMR spectroscopy and by mass spectrometry. The self‐assembly in the system was driven by hydrogen‐bonding and π–π stacking interactions. The morphology of the aggregates formed was examined by scanning electron microscopy, and the analysis suggests that aprotic solvent systems facilitate helical fibre formation, whereas introduction of protic solvents results in the formation of flat ribbons. This detailed mechanistic study suggests that the self‐assembly follows a nucleation–elongation model to form helical structures, rather than the isodesmic model.
Highly Selective Hydrothiolation of Unsaturated Organosilicon Compounds Catalyzed by Scandium(III) Triflate
Authors: Kuciński Krzysztof , Pawluć Piotr , Marciniec Bogdan , Hreczycho Grzegorz 
Published: February 2015

AbstractThe first use of a Lewis acid catalyst in the addition reaction of both aromatic and aliphatic thiols to unsaturated organosilicon compounds is reported. In catalytic tests, scandium(III) triflate demonstrates high catalytic activity in this process. Under mild conditions (25 °C, room temperature, 1–10 h) a number of thioether‐functionalized organosilicon species are obtained with appreciable selectivity. This study constitutes the first example of allylsilane hydrothiolation that gives the Markovnikov regioisomer as the main product. Ethynylsilanes are also successfully used in the hydrothiolation reaction in the presence of Sc(OTf)3.
Direct CH Amidation of Benzoic Acids to Introduce meta‐ and para‐Amino Groups by Tandem Decarboxylation
Authors: Lee Donggun , Chang Sukbok 
Published: February 2015

AbstractThe Ir‐catalyzed mild CH amidation of benzoic acids with sulfonyl azides was developed to give reactions with high efficiency and functional‐group compatibility. Subsequent protodecarboxylation of ortho‐amidated benzoic acid products afforded meta‐ or para‐substituted (N‐sulfonyl)aniline derivatives, the latter being inaccessible by other CH functionalization approaches. The decarboxylation step was compatible with the amidation conditions, enabling a convenient one‐pot, two‐step process.
An NHC‐Catalyzed In Situ Activation Strategy to β‐Functionalize Saturated Carboxylic Acid: An Enantioselective Formal [3+2] Annulation for Spirocyclic Oxindolo‐γ‐butyrolactones
Authors: Xie Yuanwei , Yu Chenxia , Li Tuanjie , Tu Shujiang , Yao Changsheng 
Published: February 2015

AbstractAn in situ NHC‐catalyzed activation strategy to β‐functionalize saturated carboxylic acid was developed. This asymmetric formal [3+2] annulation could deliver spirocyclic oxindolo‐γ‐butyrolactones from saturated carboxylic acid and isatin in good yields with high to excellent enantioselectivities. The easy availability of the starting materials, direct installation of functional units at unreactive carbon atom and the convergent assembly make this protocol attractive in the field of organic synthesis.
ChemInform Abstract: Structure of β‐AgGaO2; Ternary I—III—VI2 Oxide Semiconductor with a Wurtzite‐Derived Structure.
Authors: Nagatani Hiraku , Suzuki Issei , Kita Masao , Tanaka Masahiko , Katsuya Yoshio , Sakata Osami , Omata Takahisa 
Published: February 2015

Abstractβ‐AgGaO2 is prepared by Na+/Ag+ ion exchange of β‐NaGaO2 precursor in a mixed molten salt of AgNO3 and KNO3 (200 °C, 12 h).
ChemInform Abstract: Studies on the Thermal Stability of BiCuSeO.
Authors: Barreteau Celine , Berardan David , Dragoe Nita 
Published: February 2015

AbstractThermoelectric p‐type Pb‐free polycrystalline BiCuSeO is prepared by a two‐step solid state reaction using stoichiometric amounts of Bi2O3, Bi, Cu, and Se (silica tubes, 700 °C, 1 week) followed by densification via pressurized spark plasma sintering under Ar (675 °C, 10 min, 100 MPa).
ChemInform Abstract: Nuclear and Magnetic Supercells in the Multiferroic Candidate: Pb3TeMn3P2O14.
Authors: Silverstein Harlyn J. , Huq Ashfia , Lee Minseong , Choi Eun Sang , Zhou Haidong , Wiebe Christopher R. 
Published: February 2015

AbstractThe crystal and magnetic structures of the title compound are determined by synchrotron X‐ray and neutron diffraction.
ChemInform Abstract: Synthesis and Performance of Li4Ti5O12 Anode Materials Using the PVP‐Assisted Combustion Method.
Authors: Chang Long‐Jiao , Luo Shao‐Hua , Zhang Hai‐Liang , Qi Xi‐Wei , Wang Zhi‐Yuan , Liu Yan‐Guo , Zhai Yu‐Chun 
Published: February 2015

AbstractLi4Ti5O12 is prepared by a gel‐combustion method using polyvinylpyrrolidone as chelating agent and fuel, TiO2, and Li(OAc) in H2O at pH 3 (100 °C) before igniting the dried gel and subsequent calcination in air (800 °C, 8 h).
ChemInform Abstract: Borate Fluoride and Fluoroborate in Alkali‐Metal Borate Prepared by an Open High‐Temperature Solution Method.
Authors: Wu Hongping , Yu Hongwei , Bian Qiang , Yang Zhihua , Han Shujuan , Pan Shilie 
Published: February 2015

AbstractSingle crystals of the new compounds (V) and (VIII) are prepared by a high temperature solution flux method.
ChemInform Abstract: Synthesis of New Ga7Ge3Te11—One‐Dimensional Phase in Ga—Ge—Te Ternary System: Crystal Structure and Physical Properties.
Authors: Drasar Cestmir , Cisarova Ivana , Kucek Vladimir , Benes Ludvik , Prokleska Jan , Kratochvilova Marie 
Published: February 2015

AbstractPolycrystalline samples of compositions between Ga8Ge2Te11 and Ga6Ge4Te11 are prepared from the elements (evacuated quartz tubes, 1170 K, 2 h) from which single crystals are grown by transport in a small temperature gradient (average 960 K).
ChemInform Abstract: Chiral Room Temperature Ionic Liquids as Enantioselective Promoters for the Asymmetric Aldol Reaction.
Authors: Gonzalez Laura , Escorihuela Jorge , Altava Belen , Burguete M. Isabel , Luis Santiago V. 
Published: February 2015

AbstractChiral ionic liquids (CIL), derived from natural amino acids, are used as reaction media for direct asymmetric aldol reactions catalyzed by L‐proline.
ChemInform Abstract: Enantioselective Copper Catalyzed C—H Insertion Reaction of 2‐Sulfonyl‐2‐diazoacetamides to Form γ‐Lactams.
Authors: Clarke Leslie Ann , Ring Aoife , Ford Alan , Sinha Abhijeet S. , Lawrence Simon E. , Maguire Anita R. 
Published: February 2015

AbstractThe first example of asymmetric Cu‐catalyzed intramolecular C—H insertion reaction of title compounds (I) is described.
ChemInform Abstract: Water‐Promoted Ring‐Opening Reactions of N‐Substituted Saccharins and Phthalimides by Amines.
Authors: Bai Lisha , Zhang Xuan , Ma Ning 
Published: February 2015

AbstractVarious o‐sulfamoyl benzamides and N,N′‐disubstituted phthalamides are prepared under mild reaction conditions using water as the reaction medium.
ChemInform Abstract: Supported Palladium Oxide Nanoparticles in SBA‐15 as a Heterogeneous Catalyst for the Aerobic Oxidation of Alcohols.
Authors: Atashin Hassan , Malakooti Reihaneh 
Published: February 2015

AbstractThe title heterogeneous catalyst allows the efficient conversion of primary and secondary alcohols into the corresponding aldehydes and ketones under oxygen atmosphere.
ChemInform Abstract: Methandiide as a Non‐innocent Ligand in Carbene Complexes: From the Electronic Structure to Bond Activation Reactions and Cooperative Catalysis.
Authors: Becker Julia , Modl Tanja , Gessner Viktoria H. 
Published: February 2015

AbstractThe synthesis of a ruthenium‐carbene complex based on a dilithio methandiide and its application in O—H‐ and H—H‐ bond activation reactions as well as in the catalytic transfer hydrogenation for the reduction of acetophenone is described.
ChemInform Abstract: Efficient Cobalt‐Catalyzed C—N Cross‐Coupling Reaction Between Benzamide and Aryl Iodide in Water.
Authors: Tan Bryan Yong‐Hao , Teo Yong‐Chua 
Published: February 2015

AbstractUnder optimized conditions, a wide variety of N‐arylated benzamides (III) and (V) is obtained in good yields, in general.
ChemInform Abstract: Palladium‐Catalyzed Carbonylations of Aryl Bromides Using Paraformaldehyde: Synthesis of Aldehydes and Esters.
Authors: Natte Kishore , Dumrath Andreas , Neumann Helfried , Beller Matthias 
Published: February 2015

AbstractThe first successful application of readily available paraformaldehyde in a CO‐gas‐free synthetic protocol for palladium‐catalyzed carbonylations of aryl halides is reported.
ChemInform Abstract: Development of a Mild and Efficient Protocol for the Protection and O‐Alkylation of Allyl Alcohols.
Authors: Selvakumar Kodirajan , Prasath Lingam Kandapalam Arun , Luxmi Varma Rama Varma 
Published: February 2015

AbstractThe microwave‐assisted protection is found to proceed under clean and pyridine‐free conditions in shorter reaction time compared to the conventional method.
ChemInform Abstract: Palladium‐Catalyzed Cascade C—H Trifluoroethylation of Aryl Iodides and Heck Reaction: Efficient Synthesis of ortho‐Trifluoroethylstyrenes.
Authors: Zhang Hao , Chen Pinhong , Liu Guosheng 
Published: February 2015

AbstractAn efficient approach to the title compounds becomes possible under conditions A).
ChemInform Abstract: Base‐Free Chemoselective Transfer Hydrogenation of Nitroarenes to Anilines with Formic Acid as Hydrogen Source by a Reusable Heterogeneous Pd/ZrP Catalyst.
Authors: Tuteja Jaya , Nishimura Shun , Ebitani Kohki 
Published: February 2015

AbstractThe catalyst is recovered and reused in three additional cycles without loss of its activity.
ChemInform Abstract: Copper‐Catalyzed Three‐Component Azidotrifluoromethylation/Difunctionalization of Alkenes.
Authors: Yang Mingbo , Wang Wenlu , Liu Yin , Feng Lijie , Ju Xuexia 
Published: February 2015

AbstractA novel three‐component strategy for the azidotrifluoromethylation of alkene is developed.
ChemInform Abstract: Catalytic Cleavage of Ether C—O Bonds by Pincer Iridium Complexes.
Authors: Haibach Michael C. , Lease Nicholas , Goldman Alan S. 
Published: February 2015

AbstractOptimized conditions including the pincer complex shown allow the cleavage of substrates (I) and (III) to produce the corresponding phenol components, accompanied by olefins derived from the alkyl substituents R.
ChemInform Abstract: Enantioselective Hydrosilylation of Ketones Catalyzed by a Readily Accessible N‐Heterocyclic Carbene—Ir Complex at Room Temperature.
Authors: Shinohara Kanako , Kawabata Shun , Nakamura Hanako , Manabe Yoshiki , Sakaguchi Satoshi 
Published: February 2015

AbstractNovel types of air‐stable Ir NHC‐complexes containing a hydroxy‐amide functionalized azolium ligand are developed and used as catalyst for the asymmetric hydrosilylation of ketones in the presence of (EtO)2MeSiH under mild reaction conditions.
ChemInform Abstract: Oxidative Cleavage of α‐Sulfonyl Ketones to Carboxylic Acids with Ce(NH4)2(NO3)6.
Authors: Chang Meng‐Yang , Tsai Chung‐Yu 
Published: February 2015

AbstractA facile protocol using CAN and O2 as the co‐oxidant is developed for the oxidative cleavage of C—S and C—C bonds of α‐sulfonyl ketones to yield carboxylic acids.
ChemInform Abstract: Preparation of Highly Substituted (β‐Acylamino)acrylates via Iron‐Catalyzed Alkoxycarbonylation of N‐Vinylacetamides with Carbazates.
Authors: Ding Ran , Zhang Qiu‐Chi , Xu Yun‐He , Loh Teck‐Peng 
Published: February 2015

AbstractThe reaction proceeds with high diastereoselectivity and can be scaled up.
ChemInform Abstract: Combining Rhodium and Photoredox Catalysis for C—H Functionalizations of Arenes: Oxidative Heck Reactions with Visible Light.
Authors: Fabry David C. , Zoller Jochen , Raja Sadiya , Rueping Magnus 
Published: February 2015

AbstractThe title reactions, carried out under dual catalysis, render possible the preparation of various aryl amides with an olefin side chain in ortho position.