bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Isolated Dorsal Dislocation of the Lateral Cuneiform
Authors: Sargiotis Nikolaos V. , Korres Nektarios , Anagnostakos Konstantinos D. , Tsifetakis Stavros , Baltopoulos Panagiotis 
Published: February 2015

We present a case of an isolated dorsal dislocation of the lateral cuneiform bone. This particular injury is extremely rare and quite often escapes the initial assessment of the medical examiner. Timely and accurate diagnosis of the injury is very important as the treatment is usually surgical. Level of Evidence: Therapeutic, Level IV: Case Report
Tibialis Spastic Varus Foot With Calcaneonavicular Coalition
Authors: Kurashige Toshinori , Suzuki Seiichi 
Published: February 2015

Peroneal spastic flat foot is a well-known condition usually occurring with tarsal coalition. Conversely, tibialis spastic varus foot is a rare condition, which can be difficult to diagnose. Moreover, tibialis spastic varus foot with calcaneonavicular coalition is extremely rare, with only a few published case reports. Resection of the calcaneonavicular bar is performed in the majority of patients. We report a case of tibialis spastic varus foot with calcaneonavicular coalition in an 11-year-old boy with intellectual disability. His family noticed his right varus foot deformity 1.5 years earlier. There was no obvious history of trauma. The deformity gradually worsened with running. Because conservative treatment failed, resection of the coalition was performed that facilitated a good outcome. In this article, we report our experience of tibialis spastic varus foot with calcaneonavicular coalition and review the English literature of this condition. Level of Evidence: Therapeutic, Level IV: Case report
Role of Regional Anesthesia in Foot and Ankle Surgery
Authors: Vadivelu Nalini , Kai Alice M. , Maslin Benjamin , Kodumudi Vijay , Antony Sible , Blume Peter 
Published: February 2015

Regional anesthesia has increasingly expanded its role in the perioperative care of patients undergoing foot and ankle surgery. In addition to avoiding side effects associated with both general anesthesia and neuraxial anesthetic techniques, especially those related to cardiovascular and pulmonary systems, regional nerve blocks have been shown to improve postoperative pain and reduce hospital stay and associated expenses. The techniques utilized to achieve analgesia of the foot and ankle are diverse, multifaceted, and often incorporate ultrasound guidance. Given the aging of patient populations, and especially the growing incidence of cardiovascular-, pulmonary-, and obesity-related morbidity, the use of regional blocks is likely to expand in these surgical procedures. This review highlights some of the most current developments in the expanding role of regional anesthesia in foot and ankle surgery. Levels of Evidence: Therapeutic, Level II
Leveraging HIV Programming to Enhance Access to Noncommunicable Disease Care in Southern Botswana
Authors: Reid Michael J. A. , Haas Michelle K. , Sedigeng Pinkie , Ramogola-Masire Doreen , Friedman Harvey M. , Ho-Foster Ari 
Published: February 2015

Objective: The objective of this study was to assess whether HIV programming in southern Botswana could be leveraged to provide care for patients with noncommunicable diseases (NCDs). Methods: A retrospective analysis was performed to determine the spectrum and complexity of NCDs seen by HIV-focused outreach programming delivered between July 2011 and December 2013, to 9 facilities in southern Botswana. The association of HIV status and specific International Classification of Disease codes was examined using bivariate analysis. Results: Outreach HIV physicians recorded 926 outpatient consults involving 835 patients during the studied period. While 25% (n = 209) of patients seen were HIV infected, most patients were either HIV negative (49%, n = 410) or had an unknown HIV status (26%, n = 216). Noncommunicable disease referrals were as common at primary- and district-level facilities (90% [n = 459] versus 93% [n = 301]; P = .22). Conclusion: This study demonstrates how HIV programming in Botswana can be leveraged to improve access to specialist medical services for patients with NCDs.
Implementation of National HIV Screening Recommendations in the Indian Health Service
Authors: Reilley Brigg , Leston Jessica , Tulloch Scott , Neel Lisa , Galope Megan , Taylor Melanie 
Published: February 2015

Background: The Indian Health Service (IHS), a federal agency, provides direct patient care to an estimated 1.9 million American Indian/Alaska Native patients across a large and decentralized network of health facilities. The IHS sought to implement HIV screening of adults and adolescents per national recommendations. The IHS facilities received technical support such as electronic clinical reminders (ECRs) and sample HIV-testing policies. Purpose: To determine what facility-wide policy and practices were associated with high HIV screening rates. Methods: Survey of clinical directors of 61 federal health facilities on use of ECRs, testing policies/standing orders, and other factors associated with HIV screening. These results were correlated with HIV screening performance results for each facility as derived from the IHS national database. Results: A total of 51 (84%) of 61 facilities were interviewed. In univariate analysis, factors that were correlated with higher rates of HIV screening were having an HIV screening standing order (unadjusted odds ratio [UOR] 8.7, 95% confidence interval [CI] 2.0-37.3), sexually transmitted disease (STD) screening standing order (UOR 5, CI 1.1-21.7), having an HIV ECR in place for a year or longer (UOR 10.2, CI 2.8-37.5), and inclusion of both providers and nurses in offering HIV screening (UOR 4.8, CI 1.4-16.7). In multivariate analysis, ECRs (adjusted odds ratio [AOR] 9.1, 95% CI 1.8-45.1) and STD standing orders (AOR 7.4, 95% CI 1.1-51.0) remained significantly associated with higher HIV screening. Conclusion: Policy and practice interventions such as ECRs and standing order/testing policies and delegation of screening are correlated with high HIV screening, are scalable across health networks, and will be used for improving other infectious disease screening indicators in such as STD and hepatitis C.
BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers
Authors: Couraud Sébastien , Souquet Pierre-Jean , Paris Christophe , Dô Pascal , Doubre Hélène , Pichon Eric , Dixmier Adrien , Monnet Isabelle , Etienne-Mastroianni Bénédicte , Vincent Michel , Trédaniel Jean , Perrichon Marielle , Foucher Pascal , Coudert Bruno , Moro-Sibilot Denis , Dansin Eric , Labonne Stéphanie , Missy Pascale , Morin Franck , Blanché Hélène , Zalcman Gérard 
Published: February 2015

Lung cancer in never-smokers (LCINS) (fewer than 100 cigarettes in lifetime) is considered as a distinct entity and harbours an original molecular profile. However, the epidemiological and molecular features of LCINS in Europe remain poorly understood.All consecutive newly diagnosed LCINS patients were included in this prospective observational study by 75 participating centres during a 14-month period. Each patient completed a detailed questionnaire about risk factor exposure. Biomarker and pathological analyses were also collected. We report the main descriptive overall results with a focus on sex differences.384 patients were included: 65 men and 319 women. 66% had been exposed to passive smoking (significantly higher among women). Definite exposure to main occupational carcinogens was significantly higher in men (35%versus8% in women). A targetable molecular alteration was found in 73% of patients (without any significant sex difference):EGFRin 51%,ALKin 8%,KRASin 6%,HER2in 3%,BRAFin 3%,PI3KCAin less than 1%, and multiple in 2%.We present the largest and most comprehensive LCINS analysis in a European population. Physicians should track occupational exposure in men (35%), and a somatic molecular alteration in both sexes (73%).
PATENT PLUS: a blinded, randomised and extension study of riociguat plus sildenafil in pulmonary arterial hypertension
Authors: Galiè Nazzareno , Müller Katharina , Scalise Andrea-Viviana , Grünig Ekkehard 
Published: February 2015

PATENT PLUS evaluated the safety and efficacy of riociguat in combination with sildenafil in pulmonary arterial hypertension patients.Patients receiving sildenafil (20 mg three times daily) were randomised to placebo or riociguat (up to 2.5 mg three times daily) for 12 weeks. The primary outcome was maximum change in supine systolic blood pressure (SBP) from baseline within 4 h of dosing. Secondary objectives comprised additional blood pressure, heart rate and exploratory efficacy variables, and safety. Patients could enter a long-term extension (LTE), where all patients received riociguat plus sildenafil.There was no difference in maximum change in supine SBP from baseline within 4 h between the riociguat (n=12) (mean±sdbaseline: –20.2±15.3 mmHg; week 12: –20.7±18.0 mmHg) and placebo groups (n=6) (–7.6±3.9 and –20.2±12.9 mmHg, respectively). Changes in standing SBP and supine or standing diastolic blood pressure were also not different. Combination therapy showed no favourable effects on exploratory clinical parameters, including haemodynamics and exercise capacity. In the LTE, there were high rates of discontinuation due to hypotension and three (18%) deaths (not considered study drug-related by the investigator).There were potentially unfavourable safety signals with sildenafil plus riociguat and no evidence of a positive benefit/risk ratio. Concomitant use of riociguat with phosphodiesterase-5 inhibitors is therefore contraindicated.
Interaction effect of psychological distress and asthma control on productivity loss?
Authors: Moullec Grégory , FitzGerald J. Mark , Rousseau Roxanne , Chen Wenjia , Sadatsafavi Mohsen ,   the Economic Burden of Asthma (EBA) study team
Published: February 2015

Little is known about the potential synergistic effect of comorbid psychological distress (PD) and uncontrolled asthma (UA) on productivity loss. We estimated the productivity loss associated with the combination of these two potentially preventable conditions in employed adults with asthma.A population-based random sample of 300 adults with asthma in British Columbia, Canada, was prospectively recruited between Dec 2010 and Aug 2012. PD and productivity loss due to absenteeism and presenteeism was measured using validated instruments, and asthma control was ascertained using 2010 Global Initiative for Asthma management strategy. We used two-part regression models to study the contribution of UA and PD to productivity loss.Compared with reference group (controlled asthma (CA)+noPD), those with UA+noPD had CAD$286 (95%CI $276–297) weekly productivity loss, and those with CA+PD had CAD$465 ($445–485). Those with UA+PD had CAD$449 (437–462) in productivity loss. There was no significant interaction effect of PD with asthma control levels on productivity loss (p=0.22).In patients without PD, uncontrolled asthma was associated with a higher productivity loss than controlled asthma, but this was not the case in patients with PD. This finding can be explained by the fact that the contribution of PD to productivity loss is so large that there is no room for synergy with asthma control. Future studies should assess the impact of interventions that modify PD in patients with asthma.
Improving risk assessment in schizophrenia: epidemiological investigation of criminal history factors
Authors: Witt Katrina , Lichtenstein Paul , Fazel Seena 
Published: February 2015

BackgroundViolence risk assessment in schizophrenia relies heavily on criminal history factors.AimsTo investigate which criminal history factors are most strongly associated with violent crime in schizophrenia.MethodA total of 13 806 individuals (8891 men and 4915 women) with two or more hospital admissions for schizophrenia were followed up for violent convictions. Multivariate hazard ratios for 15 criminal history factors included in different risk assessment tools were calculated. The incremental predictive validity of these factors was estimated using tests of discrimination, calibration and reclassification.ResultsOver a mean follow-up of 12.0 years, 17.3% of men (n=1535) and 5.7% of women (n=281) were convicted of a violent offence. Criminal history factors most strongly associated with subsequent violence for both men and women were a previous conviction for a violent offence; for assault, illegal threats and/or intimidation; and imprisonment. However, only a previous conviction for a violent offence was associated with incremental predictive validity in both genders following adjustment for young age and comorbid substance use disorder.ConclusionsClinical and actuarial approaches to assess violence risk can be improved if included risk factors are tested using multiple measures of performance.
Anxiety disorders and accelerated cellular ageing
Authors: Verhoeven Josine E. , Révész Dóra , van Oppen Patricia , Epel Elissa S. , Wolkowitz Owen M. , Penninx Brenda W. J. H. 
Published: February 2015

BackgroundAnxiety disorders increase the risk of onset of several ageing-related somatic conditions, which might be the consequence of accelerated cellular ageing.AimsTo examine the association between anxiety status and leukocyte telomere length (LTL) as an indicator of cellular ageing.MethodData are from individuals with current (n = 1283) and remitted (n = 459) anxiety disorder, and controls (n = 582) with no psychiatric disorder from the Netherlands Study of Depression and Anxiety. We determined DSM-IV anxiety diagnoses and clinical characteristics by structured psychiatric interviews and self-report questionnaires; LTL was assessed using quantitative polymerase chain reaction and converted into base pairs (bp).ResultsPatients in the current anxiety group (bp = 5431) had significantly shorter LTL compared with the control group (bp = 5506, P = 0.01) and the remitted anxiety group (bp = 5499, P = 0.03) in analyses adjusted for sociodemographics, health and lifestyle. The remitted anxiety group did not differ from the control group (P = 0.84), however, time since remission was positively related with LTL. Furthermore, anxiety severity scores were associated with LTL in the whole sample, in line with a dose–response association.ConclusionsPatients with current – but not remitted – anxiety disorder had shorter telomere length, suggesting a process of accelerated cellular ageing, which in part may be reversible after remission.
Functional morphology of theAlligator mississippiensislarynx with implications for vocal production
Authors: Riede Tobias , Li Zhiheng , Tokuda Isao T. , Farmer Colleen G. 
Published: February 2015

ABSTRACTSauropsid vocalization is mediated by the syrinx in birds and the larynx in extant reptiles; but whereas avian vocal production has received much attention, the vocal mechanism of basal reptilians is poorly understood. The American alligator (Alligator mississippiensis) displays a large vocal repertoire during mating and in parent–offspring interactions. Although vocal outputs of these behaviors have received some attention, the underlying mechanism of sound production remains speculative. Here, we investigate the laryngeal anatomy of juvenile and adult animals by macroscopic and histological methods. Observations of the cartilaginous framework and associated muscles largely corroborate earlier findings, but one muscle, the cricoarytenoideus, exhibits a heretofore unknown extrinsic insertion that has important implications for effective regulation of vocal fold length and tension. Histological investigation of the larynx revealed a layered vocal fold morphology. The thick lamina propria consists of non-homogenous extracellular matrix containing collagen fibers that are tightly packed below the epithelium but loosely organized deep inside the vocal fold. We found few elastic fibers but comparatively high proportions of hyaluronan. Similar organizational complexity is also seen in mammalian vocal folds and the labia of the avian syrinx: convergent morphologies that suggest analogous mechanisms for sound production. In tensile tests, alligator vocal folds demonstrated a linear stress–strain behavior in the low strain region and nonlinear stress responses at strains larger than 15%, which is similar to mammalian vocal fold tissue. We have integrated morphological and physiological data in a two-mass vocal fold model, providing a systematic description of the possible acoustic space that could be available to an alligator larynx. Mapping actual call production onto possible acoustic space validates the model's predictions.
Circularly Polarized Luminescence of Chiral Binaphthyl with Achiral Terthiophene Fluorophores
Authors: Taniguchi Naoya , Nakabayashi Kazuki , Harada Takunori , Tajima Nobuo , Shizuma Motohiro , Fujiki Michiya , Imai Yoshitane 
Published: February 2015

Abstract
Unlike in the solution state, the first circularly polarized luminescence (CPL) property of the axially chiral binaphthyl fluorophore bearing two fluorescent terthiophene units was successfully observed by chirality transfer from axially chiral binaphthyl to the terthiophenes, followed by amplified CPL signals in the solid state.
Generalized quasi-reversibility method for a backward heat equation with a fractional Laplacian
Authors: Koba Hajime , Matsuoka Hideki 
Published: February 2015

Abstract
This paper considers a backward problem on a heat equation with a fractional Laplacian. It is not easy to solve a backward heat equation directly. This problem is a well-known ill-posed problem. In order to consider a backward heat equation with a fractional Laplacian, we apply the N-th power of the Dirichlet-Laplacian and small parameters to regularize the equation. This method is called a quasi-reversibility method. We use the generalized quasi-reversibility method to change the backward heat system into another system. This paper shows the existence of a strong solution of the modified backward heat system, and derives L
2-estimates of the difference between a solution of the heat equation with the fractional Laplacian and a solution of our system.
Dummy molecularly imprinted mesoporous
silicates for selective adsorption of 2-naphthol
Authors: Luoa Guitao , Li Yunping , Wang An , Lin Qiang , Zhang Guolin , Wang Chun 
Published: February 2015

Abstract
Dummy molecularly imprinted
mesoporous silicates (MIMS-2) were made by
co-condensation of tetraethyl orthosilicate (TEOS)
with precursors of bi-functional mimic of 2-naphthol,
2,7-dihydroxynaphthalene, around triblock copolymer
surfactant Pluronic (P123) micelles. The bi-functional
template was linked to two functional monomers through
thermally cleavable covalent bonds to generate imprint
precursor. This provides the possibility of incorporating
the target into the cross-linked mesoporous silicate matrix
in the non-ionic surfactant templated sol-gel process.
P123 was eluted by ethanol extraction and template
molecules were removed by refluxing the materials in a
mixture of dimethyl sulfoxide (DMSO) and water. MIMS-1
was prepared similarly except that 2-naphthol was used
as template instead of 2,7-dihydroxynaphthalene. Solid
phase extraction studies showed that MIMS-2 exhibited
good retention and selectivity for 2-naphthol among its
structural analogues. The mono-functional molecule
2-naphthol was unable to be incorporated into the silica
matrix of mesoporous material by the identical method,
and the resulting material MIMS-1 exhibits poor selectivity
to the template analogues.
E
1-degeneration of the irregular Hodge filtration
Authors: Esnault Hélène , Sabbah Claude , Yu Jeng-Daw 
Published: February 2015

Abstract
For a regular function f on a smooth complex quasi-projective variety, J.-D. Yu introduced in [35] a filtration (the irregular Hodge filtration) on the de Rham complex with twisted differential

d
+

d
⁢
f

{\mathrm{d}+\mathrm{d}f}

, extending a definition of Deligne in the case of curves. In this article, we show the degeneration at

E
1

{E_{1}}

of the spectral sequence attached to the irregular Hodge filtration, by using the method of [26]. We also make explicit the relation with a complex introduced by M. Kontsevich and give details on his proof of the corresponding

E
1

{E_{1}}

-degeneration, by reduction to characteristic p, when the pole divisor of the function is reduced with normal crossings. In Appendix E, M. Saito gives a different proof of the

E
1

E_{1}

-degeneration.
The mean square of the product of the Riemann zeta-function with Dirichlet polynomials
Authors: Bettin Sandro , Chandee Vorrapan , Radziwiłł Maksym 
Published: February 2015

Abstract
Improving earlier work of Balasubramanian, Conrey and Heath-Brown
[1],
we obtain an asymptotic formula for the mean-square of the
Riemann zeta-function times an arbitrary Dirichlet polynomial of length

T

1
2

+
δ

{T^{\frac{1}{2}+\delta}}

, with

δ
=

0.01515
⁢
…

\delta=0.01515\dots

.
As
an application we obtain an upper bound of the correct order of magnitude
for the third moment of the Riemann zeta-function.
We also refine
previous work of Deshouillers and Iwaniec [8], obtaining asymptotic
estimates in place of bounds.
Using the work of Watt [19], we compute the mean-square of the Riemann
zeta-function times a Dirichlet
polynomial of length going up to

T

3
4

{T^{\frac{3}{4}}}

provided that the Dirichlet
polynomial assumes
a special shape. Finally, we exhibit a conjectural estimate for trilinear
sums of Kloosterman fractions which implies the Lindelöf Hypothesis.
UV-Cured polypropylene mesh-reinforced composite polymer electrolyte membranes
Authors: Çakmakçı Emrah , Uğur Mustafa Hulusi , Güngör Atilla 
Published: February 2015

AbstractIn this study, a polypropylene (PP) mesh was used to prepare proton- and Li+ conducting composite membranes for fuel cells and lithium rechargeable batteries, respectively. For the preparation of Li+ conducting membrane, polypropylene mesh was first immersed in an electrolyte solution, which was composed of LiBF4 and ethylene carbonate. Then the swollen membrane was immersed in an acetone solution of polyethylene glycol diacrylate (PEGDA), polyvinylidenefluoride-co-hexafluoro-propylene and photoinitiator. Finally, PP fabric was taken out from the solution and exposed to UV irradiation. Furthermore, proton conducting membranes were prepared by immersing the PP mesh into a mixture of vinyl phosphonic acid, PEGDA and photoinitiator. Afterwards, samples were cured under UV light. PP-reinforced membranes designed for fuel cell applications exhibited a room temperature conductivity of 3.3×10-3 mS/cm, while UV-cured electrolyte for Li batteries showed ionic conductivities in the range of 1.61×10-3–5.4×10-3 S/cm with respect to temperature. In addition, for lithium-doped composite polymer electrolyte (CPE), the electrochemical stability window was negligible below 4.75 V vs. Li/Li+. It is concluded that lithium-doped CPE has suitable electrochemical stability to allow the use of high-voltage electrode couples.