bluuebunny/crossref_metadata_2025_split huggingface dataset:
Revitalizing Dead Zinc with Ferrocene/Ferrocenium Redox Chemistry for Deep‐Cycle Zinc Metal Batteries
Authors: Qian Xiaohu , Chen Tao , Wang Yinan , Zhang Qianjin , Li Wenqi , Fu Jiajun 
Published: August 2024

AbstractAqueous zinc (Zn) batteries are highly desirable for sustainable and large‐scale electrochemical energy storage technologies. However, the ceaseless dendrite growth and the derived dead Zn are principally responsible for the capacity decay and insufficient lifespan. Here, we propose a dissolved oxygen‐initiated revitalization strategy to reactivate dead Zn via ferrocene redox chemistry, which can be realized by incorporating a trace amount of poly(ethylene glycol) as a solubilizer to improve the solubility of water‐insoluble ferrocene derivatives. Ferrocene scaffold can be spontaneously oxidized to ferricenium cations by dissolved oxygen, which eradicates the dissolved oxygen‐involved Zn corrosion and insulating by‐product generation. Subsequently, the generated ferricenium cations as the scavenger can rejuvenate electrically isolated dead Zn into electroactive Zn2+ ions to compensate the zinc loss. Through this design, the symmetric cell exhibited improved cycle life of 3700 h at 10 mA cm−2, and 220 h under a high depth of discharge of 80 %. Importantly, the Zn||NaV3O8 ⋅ 1.5H2O full cells demonstrated the impressive cycling stability over 1500 cycles at a low N/P ratio of 3.0. This work presents an innovative solution for the revitalization of dead Zn to extend the lifespan of deep‐cycling metal batteries.
C1‐4 Alkylation of Aryl Bromides with Light Alkanes enabled by Metallaphotocatalysis in Flow
Authors: Pulcinella Antonio , Chandra Tiwari Prakash , Luridiana Alberto , Yamazaki Ken , Mazzarella Daniele , Sadhoe Akshay K. , Alfano Antonella Ilenia , Tiekink Eveline H. , Hamlin Trevor A. , Noël Timothy 
Published: August 2024

AbstractThe homologous series of gaseous C1‐4 alkanes represents one of the most abundant sources of short alkyl fragments. However, their application in synthetic organic chemistry is exceedingly rare due to the challenging C−H bond cleavage, which typically demands high temperatures and pressures, thereby limiting their utility in the construction of complex organic molecules. In particular, the formation of C(sp2)−C(sp3) bonds is crucial for constructing biologically active molecules, including pharmaceuticals and agrochemicals. In this study, we present the previously elusive coupling between gaseous alkanes and (hetero)aryl bromides, achieved through a combination of Hydrogen Atom Transfer (HAT) photocatalysis and nickel‐catalyzed cross coupling at room temperature. Utilizing flow technology allowed us to conduct this novel coupling reaction with reduced reaction times and in a scalable fashion, rendering it practical for widespread adoption in both academia and industry. Density Functional Theory (DFT) calculations unveiled that the oxidative addition constitutes the rate‐determining step, with the activation energy barrier increasing with smaller alkyl radicals. Furthermore, radical isomerization observed in propane and butane analogues could be attributed to the electronic properties of the bromoarene coupling partner, highlighting the crucial role of oxidative addition in the observed selectivity of this transformation.
The “virtual” child: The unconscious functions of child sexual exploitation material
Authors: Brown Julie , O' Neill Ray 
Published: August 2024

AbstractThe narratives of individuals using child sexual exploitation material (CSEM) highlight the individual and unconscious functions of this type of sexual offense. Fluid cycles of projection into and identification with the children in the imagery were evident, as were marked differences in the intensity and exclusivity of pedophilic sexual preference. Anger was a common trigger, but conscious awareness of any associated hostilities toward the child in the imagery was vigorously defended against. The Internet, the now dominant context of child sexual abuse, offers a distinct type of environment, on the porous boundary between the internal and the external, that seems to encourage regression to early, varied paraphilic sexuality and part‐object relations. Interactions in online forums facilitated the projection of pedophilic interests and sadistic impulses into other users. Broad empirical findings on the characteristics of those who use CSEM, coupled with this study and clinical experience, suggest that many who engage in this activity have an essentially neurotic structure.
Audiovisual integration and sensory dominance effects in older adults with subjective cognitive decline: Enhanced redundant effects and stronger fusion illusion susceptibility
Authors: Li Shengnan , Yang Weiping , Li Yueying , Li Ruizhi , Zhang Zhilin , Takahashi Satoshi , Ejima Yoshimichi , Wu Jinglong , Zhou Mengni , Yang Jiajia 
Published: August 2024

AbstractIntroductionSubjective cognitive decline (SCD) refers to individuals’ perceived decline in memory and/or other cognitive abilities relative to their previous level of performance. Sensory decline is one of the main manifestations of decline in older adults with SCD. The efficient integration of visual and auditory information, known as audiovisual integration, is a crucial perceptual process. This study aims to evaluate audiovisual integration in older adults with SCD.MethodsWe adopted the audiovisual detection task, the Colavita task, and the Sound‐Induced Flash Illusion (SIFI) task to evaluate the audiovisual integration by examining both redundant and illusory effects. Older adults diagnosed with SCD (N = 50, mean age = 67.8 years) and a control group of non‐SCD older adults (N = 51, mean age = 66.5 years) were recruited. All participants took part in the three aforementioned experiments.ResultsThe outcomes showed that a redundant effect occurred in both SCD and non‐SCD older adults, with SCD older adults gaining more benefits in audiovisual detection task. Moreover, an equivalent amount of the visual dominance effect was observed among both SCD and non‐SCD older adults in Colavita task. In addition, older adults with SCD perceived an equal fission illusion but a bigger fusion illusion compared with non‐SCD older adults in SIFI task.ConclusionsOverall, older adults with SCD exhibit increased audiovisual redundant effects and stronger fusion illusion susceptibility compared to non‐SCD older adults. Besides, visual dominance was observed in both groups via the Colavita task, with no significant difference between non‐SCD and SCD older adults. These findings implied that audiovisual integration might offer a potential way for the identification of SCD.
Assessment of swallowing performance in patients with neurodegenerative disease: A hierarchical cluster analysis
Authors: Tosun Samet , Karali Fenise Selin , Kacar Kutukcu Dilber , Cinar Nilgün , Kendirli Sude , Sen Aksut Meltem , Albayrak Ilayda , Celik Yusuf 
Published: August 2024

AbstractBackgroundSwallowing is a complex process that alters with age and neurological diseases; swallowing disorders can be a consequence of both of them. As an advanced multivariate statistical method, hierarchical cluster analysis (HCA) was utilized to make the dendrograms, which was used to find the relationship between the variables. The purpose of this study is to ascertain the type of clustering exhibited by the variables using HCA and to evaluate the approach to major neurodegenerative diseases (MND) with swallowing disorders based on the results obtained.MethodsData were collected from a total of 173 patients from various neurological diagnoses, such as dementia, Parkinson's disease, stroke and polyneuropathy, aging between 42 and 104 (mean of age 72.85) by using the Montreal Cognitive Assessment, the Edinburgh Feeding Evaluation Scale (EdFED), the Eating Assessment Tool (EAT‐10), and the Modified Mann Swallowing Ability test. From the collected data, dendrograms were formed by using HCA with Ward linkage method.ResultsBased on cluster analysis results, clusters demonstrate statistical significance. They center around EdFED, EAT‐10, and age in each MND. In healthy individuals, variables are not clustered as in the patient group. This study holds importance as it can give clinicians a different perspective on determining and managing the elderly population's swallowing problems.ConclusionsThe HCA method explicitly proposes which variables should be examined concurrently in the clinic for MND. This research is one of the pioneering studies conducted by using the HCA method.
Similar usage of T‐cell receptor β‐chain between tumor and adjacent normal tissue in hepatocellular carcinoma
Authors: Yang Jie‐Zuan , Xu Shao‐Yan , Xiao Dang‐Sheng , Li Jin‐You , Jin Xiu‐Yuan , Yan Dong 
Published: August 2024

AbstractBackgroundIn this study, we comprehensively profiled the T‐cell receptor (TCR) repertoire of the tumor and adjacent normal tissue in patients with HBV‐associated hepatocellular carcinoma (HCC) and determined the baseline characteristics and clinical significance of TCR.MethodsHigh‐throughput sequencing was used to determine the profile of complementarity‐determining region 3 (CDR3) of the TCR‐β chain variable (TRBV) in the tumor and normal tissue samples of 14 HCC patients. At the same time, TRBV diversity and differences in expression between tumor and normal tissues were investigated. The cumulative frequency of top 100 CDR3 (CF100), clonality, and Shannon entropy as indices to evaluate diversity,ResultsThe diversity of TRBV CDR3 showed no significant difference between tumor and normal tissues. Of the 58 V gene segments in TRBV, TRBV16 and TRBV7‐6 had a significantly higher frequency in the tumor group than in the normal group (p < 0.05). The frequency of 14 J gene segments showed no significant difference between tumor and normal tissues. In contrast, the frequency of 22 TRBVx/BJx combinations was significantly higher in the tumor than in the normal tissue. In addition, the length and type of TRBV CDR3 were similar in tumor and normal tissues, and a Gaussian distribution was observed in both groups.ConclusionThis study provided a large amount of information about the TCR lineage in HBV‐associated HCC, laying the foundation for further research. In addition, the fact that the immune repertoire (TRBV CDR3) hardly differs between tumor and adjacent normal tissue provides a new clue for exploring the mechanism of the liver as an organ with immune privileges.
Evolving patterns in systemic treatment utilization and survival among older patients with advanced cutaneous melanoma
Authors: Hong Yoon Duk , Enewold Lindsey , Sharon Elad , Warner Jeremy L. , Davidoff Amy J. , Zeruto Chris , Mariotto Angela B. 
Published: August 2024

AbstractIntroductionIn the last decade, melanoma treatment has improved significantly. However, data on population‐level treatment utilization and survival trends among older patients is limited. This study aimed to analyze trends in systemic anticancer therapy (Rx), including the uptake of immune checkpoint inhibitors (ICIs), in conjunction with trends in cause‐specific survival among older patients (66+) diagnosed with advanced melanoma (2008–2019).MethodsWe used the Surveillance, Epidemiology, and End Results (SEER)‐Medicare Condensed Resource to assess any Rx utilization among patients first diagnosed with advanced melanoma in 2008–2010, 2011–2014, and 2015–2019, stratified by stage, and type of first‐line Rx among patients receiving Rx. The SEER dataset was used to evaluate trends in cause‐specific survival by year of diagnosis.ResultsRx utilization (any type) almost doubled, from 28.6% (2008–2010) to 55.4% (2015–2019) for stage 3 melanoma, and from 35.5% to 68.0% for stage 4 melanoma. In 2008–2010, the standard first‐line treatment was cytokines/cytotoxic chemotherapy/other. By 2015–2019, only 5.1% (stage 3) and <3.6% (stage 4) of patients receiving Rx received these agents, as ICIs emerged as the dominant treatment. Both 1‐year and 5‐year cause‐specific survival significantly improved since 2010 for stage 4 and since 2013 for stage 3.ConclusionsThis study shows a significant rise in Rx utilization and a rapid transition from cytokines/cytotoxic chemotherapy to ICIs, reflecting a rapid uptake of highly effective treatment in a previously challenging disease with limited options before 2011. The documented survival improvement aligns with the adoption of these novel treatments, underscoring their significant impact on real‐world patient outcomes.
Measuring accumulation: Constructing a tool for evaluating cumulative harm in children engaged with an intensive family support service
Authors: Bryce India , Collier Simone , Harris Lottie , Higgins Daryl , Toohey Joseph 
Published: August 2024

AbstractThere is a significant body of research that attests to the deleterious impact of an accumulation of adverse childhood experience across the lifespan, which provides a strong rationale for the development of a means for evaluating this accumulation in a high‐risk population. We developed a theory‐driven measure, the Cumulative Experiences Index, and conducted a pilot study to test its utility. The Cumulative Experiences Index derives a cumulative harm score that can be used to inform intervention and prevention strategies, programmes and initiatives across all tiers of public health prevention intervention. The Cumulative Experiences Index was piloted with 50 participants aged 8–17 years old who were actively engaged with an Intensive Family Support service. The study explores whether cases rated as low, medium or high severity on the Cumulative Experiences Index corresponded with severity ratings on the three measures of concurrent validity: the Strengths and Difficulties Questionnaire, Kessler‐10 and Children's Revised Impact of Events Scale. The Index provides a valid and accurate means of reflecting the interconnectedness and complexity of exposure to different forms of harm that accumulates over time. Practitioners and researchers will benefit from using the Cumulative Experiences Index—a new valid and reliable measure of cumulative harm.
The effect of category‐specific temporal frame on temporal reframing of price
Authors: Chung Miri , Sheinin Daniel A. 
Published: August 2024

AbstractThis study explores the effects of temporal reframing of price (TRP), a strategy presenting the total cost of a product or service in smaller, segmented amounts (e.g., $1 per day rather than $365 in total), and its potential to intensify consumers' feelings of being misled, thereby negatively impacting their attitudes toward the product. While previous research has underscored the benefits of TRP, such as lowering perceived costs and enhancing perceived benefits through heuristic information processing, the current study, informed by theories of heuristic versus systematic processing and attribution theory, investigates whether TRP leads to increased feelings of manipulation by deviating from conventional category‐specific temporal frames of pricing. Through two experiments, we find that such deviations may prompt consumers to view TRP as manipulative, subsequently heightening feelings of being misled, especially at higher price levels, whereas lower price levels could diminish the scrutiny applied to marketers' intentions. Additionally, this study demonstrates that feelings of being misled mediate the relationship between the presentation of price information and product attitude, highlighting the potential risks of employing TRP strategies. The paper discusses optimal situations for implementing TRP, aiming to navigate its strategic use effectively.
Deciphering the 4′,7‐Dihydroxy‐3′‐Methylflavone from Boerhavia, Agonist/Antagonist Interactions Against 5‐HT2 Receptors using Homology Modeling, Molecular Docking, and Dynamic Simulation Studies
Authors: Salaria Punam , Niharika Desu Gayathri , N. Subrahmanyeswara Rao N. , Ganapati P. Lakshmi , M. Amarendar Reddy 
Published: August 2024

AbstractSeizures, depression, and anxiety are neurological disorders that affected innumerable people worldwide. Recent research has revealed that targeting 5‐hydroxytryptamine 2 (5‐HT2) receptors can help suppress these conditions. An in‐depth literature study has identified that phytocompounds from the Boerhavia genus could reduce seizures. Therefore, homology models of 5‐HT2 receptors were generated and validated using techniques such as the alignment of amino acid sequences and the Ramachandran plot. Later, a comparison of modeled structures was made with a non‐redundant set of PDB structures. The pharmacokinetics, drug‐likeness, blood‐brain barrier (BBB) permeability, and Lipinski's rule of five shed light on 22 phytocompounds, which are the potential candidates for molecular docking among 127 Boerhavia's bioactive. Notably, molecular docking analysis revealed 4′,7‐dihydroxy‐3′‐methylflavone as the most potent lead compound, which has a strong binding affinity to all modeled receptors. Additionally, with a remarkably high docking score of −9.1 kcal/mol, 4′,7‐dihydroxy‐3′‐methylflavone showed promising interactions, particularly with 5‐HT2A receptor, as seen from the RMSD, SASA, Rg, and number of hydrogen bonds during 100 ns molecular dynamic (MD) simulation. Principal component analysis (PCA) and Molecular Mechanics‐Poisson‐Boltzmann Surface Area (MM‐PBSA) further confirmed that 4′,7‐dihydroxy‐3′‐methylflavone is the best novel phytocompound in Boerhavia genus for 5‐HT2 receptor as agonist/antagonist activity against seizures.
Adipose tissue allograft for the management of a pre‐ulcerative plantar lesion in a diabetic neuropathic patient
Authors: Regulski Matthew J. , Saunders Molly C. , McCulloch Sharron E. 
Published: August 2024

Key Clinical MessageThis case describes a minimally invasive implantation of cryopreserved human adipose tissue allograft (CAT) in a diabetic neuropathic patient with a pre‐ulcerative plantar lesion. No re‐ulceration or adverse events have occurred out to 9 months. CAT provides healthcare providers with an option to manage patients at risk for plantar ulcers.
Omental metastases from uveal melanoma—An interesting intraoperative omental pattern appearance
Authors: Stavros Sofoklis , Zikopoulos Athanasios , Potiris Anastasios , Baltogiannis Dimitrios , Skentou Chara , Domali Ekaterini , Drakakis Peter 
Published: August 2024

Key Clinical MessageUveal melanomas represent approximately 5% of all human melanomas. Omental metastases are often diagnosed as secondary metastatic sites and only a few cases have been described as the first single manifestation of distant metastasis. In this case image, we illustrate the interesting appearance of the metastatic localization of metastatic uveal melanoma.
Metal–Organic Frameworks as a Catalyst and Catalyst Support in Fuel Cells: From Challenges to Catalytic Application
Authors: Letchumanan Iswary , Wani Ajaz Ahmad , Shaari Norazuwana , Beygisangchin Mahnoush , Kamarudin Siti Kartom , Karim Nabila A. 
Published: August 2024

AbstractThe innovation of high‐performance, stable electrocatalysts for clean energy systems faces significant challenges. Metal‐organic frameworks (MOFs), with their porous nature, flexible structures, and homogeneous active site dispersion, have gained interest as unique precursors for carbon‐based catalysts. MOFs' properties significantly enhance catalytic performance in fuel cells. This review highlights recent advancements in MOF design for oxygen electrocatalysis in fuel cells, while also discussing perspectives for future material innovations to improve catalytic activity in this emerging field.
Introduction of Molecular Complexity via the Cross‐Coupling of Lithium 1,4‐Dioxene with Aryl Bromides
Authors: Visser Paco , Feringa Ben L. 
Published: August 2024

AbstractThe synthetic potential of substituted 1,4‐dioxenes is well recognised, although the chemistry of 2‐aryl‐1,4‐dioxenes is relatively unexplored. Their transition metal‐catalysed synthesis has been limited to Stille‐type cross‐coupling chemistry, typically showing long reaction times, or proceeding at high reaction temperatures. Here we present a facile and general methodology for the cross‐coupling of aryl bromides with lithium 1,4‐dioxene, affording a range of 2‐aryl‐1,4‐dioxenes in generally good yields. We highlight the synthetic applicability of this transformation at multigram scale, and demonstrate the versatility of the products by conversion of the dioxene units to various carbonyl‐based functionalities. Additionally, we present a concise two‐step synthesis of an arylated analogue to a known 1,4‐dioxene‐based antifungal agent.
Synthesis of Hetero‐Trimetal Porphyrin Nanobelts
Authors: Xue Songlin , Lv Xiaojuan , Dong Yuting , Zhang Tao , Qiu Fengxian , Pan Jianming , Kuzuhara Daiki , Yamada Hiroko , Aratani Naoki 
Published: August 2024

AbstractThis work reported “trinitarian” porphyrin nanobelts, contained hetero‐trimetal ions. The high‐resolution mass spectrometry and X‐ray crystallography proved PNBNiCuPd consisting of three different bent porphyrin(2.1.2.1) metal complex moieties. The redox properties indicate porphyrin nanobelts demonstrate the multielectron donating and accepting properties, more than nine redox processes.
Potential and Limits of Augmented Reality in Engineering Education and Industry 4.0
Authors: Grodotzki Joshua , Müller Benedikt Tobias , Weck Daniel , Gude Maik , Tekkaya A. Erman 
Published: August 2024

AbstractAs a young class of socio‐technical systems, Augmented Reality (AR), which enriches the real world with virtual information, is becoming increasingly important. It offers a variety of possibilities in the areas of education and training. Here, interactive and immersive learning experiences increase motivation and learning success. AR also enables the specific support of workers in the production environment. When dealing with complex tasks, AR applications help workers to increase efficiency and quality. Based on the developments of the BMBF collaborative project KORESIL, this paper contains an overview of the current application scenarios of AR in teaching and industry. The outlook provides an analysis of this technology's potential and identifies current challenges in hard‐ and software.
Industry 4.0 Ready: Transforming STEM Laboratory Courses – Continuous Distillation as Example
Authors: Götze Katja , Kaiser Doreen , Aubel Ines , Herdegen Volker , Bertau Martin 
Published: August 2024

AbstractLaboratory courses are key to science, technology, engineering, and mathematics (STEM) programs in higher education, but often lack the flexibility for distance learning and inclusiveness for all students. To address these challenges, TU Bergakademie Freiberg introduced remote laboratories not only for international degree programs and the “Disti4Study” application, which provides interactive visualization of industrial thermal separation processes. This paper focuses on the development and didactic challenges associated with the “Continuous Distillation Laboratory”. It illustrates how rethinking the technical and didactic frameworks of traditional laboratories can align with new learning objectives, such as those related to Industry 4.0, including the Internet of Things and data management.