bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of antibacterial susceptibility profile in pregnant women with asymptomatic bacteriuria in Kadapa
Authors: Kamparj Sadgunothama Goud , Hajira Hakeem Sayeda Bee Bee , Imrana Hassan Shaikh 
Published: August 2024

: The bacterial urinary tract infection in pregnancy may be symptomatic (cystitis, pyelonephritis) or asymptomatic (bacteriuria without symptoms). Empirical antimicrobial therapy may be affected by resistance of uropathogens due to the irrational use of antibiotics. This prevalence of resistance is rising and varies across the globe due to different treatment recommendations which may be determined by taking into account frequently occurring infections, susceptibility patterns, evidence, physician acceptance, antimicrobial stewardship norms, availability of formularies, and antimicrobial prices. So the current research was carried out. : A cross-sectional study was conducted among pregnant women with UTI attending antenatal care (ANC) by excluding pregnant women who had taken antibiotics within the two weeks prior to their ANC follow-up and symptomatic UTI pregnant women. The antibiotic sensitivity of the uropathogens and their identification were evaluated by conventional culture, microbiological techniques and sensitivity tests. The results were analysed by SPSS software for descriptive statistics. : 377 pregnant women with UTI participated in the present study. The results demonstrated that most of the participants who lived in urban areas (64%) were affected. The results also suggest that 42% of participants who had secondary education as the highest level of education, 45% of participants belonged to an upper middle-class family and, 40% of working professionals in the study were affected. Out of 103 isolates, 79 isolates were gram negative & 24 were Gram positive. Out of seventy-nine gram negative isolates, the major contribution was by (36), . (26). Among 24 gram positive isolates, the major contribution was by Coagulase Negative Staphylococci (CONS) (12). The uropathogens were shown diverse antibiotic sensitivity for the study test drugs. : This study concludes that the antibacterial susceptibility and resistance of uropathogens may vary in different geographical areas based on antibiotic usage and circumstances. This study also demonstrated the imperative prerequisite of periodic assessments.
Serratiopeptidase with diclofenac sodium for the management of post-operative pain and inflammation in a day care obstetric and gynaecological surgeries
Authors: Kumar Abhijeet , Bapat Kawita , Katke Prashant , Kulkarni Ketan , Suryawanshi Sachin 
Published: August 2024

Management of acute post-operative pain and swelling after the obstetric and gynaecological (OBG) surgeries is crucial part of patient care. Reduction or complete elimination of post-operative pain & swelling, without excessive sedation is the most preferred treatment strategy helping patient’s recovery in terms of rapid mobilization and return to independence. Serratiopeptidase a proteolytic enzyme used for its anti-inflammatory properties. Diclofenac Sodium is commonly used to treat the pain and swelling. This study aimed to evaluate the effectiveness and tolerability of the fixed dose combination (FDC) of Serratiopeptidase (10 mg) with Diclofenac Sodium (50 mg) gastro-resistant tablets in day care OBG surgery. This was a single centre, retrospective, observational data collection in real-life scenario. Data of adult women who had undergone day care OBG surgery and received a FDC of Serratiopeptidase (10 mg) with Diclofenac Sodium (50 mg) gastro-resistant tablets TID for period of 24 hours was retrieved and analysed. VAS (Visual Analogue Scale) data on post-operative pain at rest and pain on movement as well as post-operative swelling were analyzed in conjunction with monitoring for adverse events. Among 61 patient’s data included in the study, 40 (65.57%) had undergone Minimally Invasive Vaginal Hysterectomy (MIVH), 4 (6.56%) had MIVH with Bilateral Salpingo-oophorectomy, and 17 (27.87%) had other OBG surgeries. The average VAS scores for pain at rest (VAS), pain on movement (VAS) and swelling were significantly reduced compared to baseline at all-time points (p&#62;0.001). Clinical global impression of efficacy and safety for 95% physician’s and 93.3% patients was good to very good. FDC was found to be well tolerated without any serious adverse reaction. The results of this clinical study confirms the effectiveness and tolerability of FDC of Serratiopeptidase and Diclofenac sodium in day care OBG surgeries in the early post-operative period.
Epidemiological, clinical and psychological aspects of victims of female child sexual abuse in the gynaecology and obstetrics department of tertiary hospital, Karnataka
Authors: Karelal Saraswathi , Puneetha V S  , Raju S Ashwini , Huchchannavar Raghavendra R 
Published: August 2024

Child sexual abuse is an alarming reality that although is recognized as a serious violation of human well-being and of the law often goes unreported or overlooked. The present study was planned to identify the clinic-social profile of victims of child sexual abuse, circumstances under which these heinous crimes have occurred and study the psychological status of the victims. A retrospective record-based study from January 1, 2017 to December 31, 2021 conducted in a tertiary care hospital of north Karnataka, India. All the female patients aged less than 18 years admitted during our investigation period who were victims of child sexual abuse were included in the study. All case reports obtained from the medical record division and fulfilling the inclusion criteria were scrutinized by the authors for completeness of data. The data was entered in MS excel master sheet and statistical analysis was performed using SPSS software version 22. A total of 158 victims of female child sexual abuse were documented in our centre. The age of the victims ranged from 1 to 17 years and that of abusers varied from 15 years to 75 years. For most incidents, the offenders were known to the victims. The highest incidence of sexual assault was reported in abusers’ home, followed by victim’s home. Majority of the female children were abused multiple times (45.6%). There is an urgent need for comprehensive prevention programs, awareness campaigns, accessible support services, public awareness campaigns and legal enhancements to address CSA effectively in schools and communities that educate children on recognizing and reporting abuse.
Knowledge, attitudes, awareness and factors associated with the uptake of influenza vaccine among pregnant women in urban Pune
Authors: Shaikh Hanif , Undale Vaishali , Pardeshi Anil , Jadhav Shweta , Jagtap Pratiksha , Aphale Parth , Kawade Anand , Asalkar Mahesh , Agampodi Suneth , Upaganlawar Aman , Upasani Chandrashekhar 
Published: August 2024

: This cross-sectional study was aimed to assess the knowledge, attitudes, awareness, facilitators, and barriers associated with the uptake of influenza vaccination during pregnancy in the urban area of Pune. : The study was conducted with 500 participants: 62 pregnant women and 438 postpartum women (total 524 were approached) attending Obstetrics and Gynaecology outpatient department (OPD) in a tertiary-care municipal hospital in Pune. The study-questionnaire collected data regarding socio-demographics general knowledge about influenza, attitude towards influenza vaccination, vaccine risk awareness, and its potential risk and benefits during pregnancy. The log-binomial regression models were used to examine the factors associated with influenza vaccination. : A good uptake of the vaccine (223/500, 44.6%) was found during current pregnancy of the participant; however, only 2.7% of study-participants vaccinated with influenza vaccine in their previous pregnancies. Also, there was poor awareness among all the participants regarding the safety of the seasonal influenza vaccine during pregnancy (19%, n=95/500). 11.2% (n=31/277) study-participants were found to be against the maternal influenza vaccination. Women receiving the vaccine against influenza were more likely to be previously informed of the recommendations from health-care providers about maternal influenza vaccination with odds ratio of 0.18 (95% CI, 0.04 to 0.8; p&#60;0.00001), received the influenza vaccine in the past OR 8.27 (95% CI, 0.94 to 72.0), Z 1.09, p=0.05 and of having knowledge on influenza and its complications has more impact on influenza vaccination during pregnancy OR 14.4 (95% CI, 5.68 to 36.53), Z 5.6, p&#60;0.0001 respectively.: This study concludes the vital causative factors for non-vaccination were provision of incomplete information or poor awareness about influenza vaccination (68.6%). There was poor knowledge among the pregnant women regarding the safety of maternal influenza vaccines. The recommendation from healthcare professionals is the major facilitators of decision-making by pregnant women for influenza vaccination during pregnancy.
Facing the unimaginable: Case series of hysterotomy at a tertiary care centre
Authors: Madan Shikha , Dahiya Sonia , Anand Smriti , Dahiya Pushpa , Singhal Savita Rani 
Published: August 2024

Hysterotomy is a surgical procedure involving a planned incision in the uterus. Although it is not commonly used for abortions, its incidence has increased due to higher rates of caesarean sections and placenta accreta spectrum.We report three such cases, first of a retained head of decapitated fetus; second of a patient with previous three caesarean section; and third of a patient with placenta previa. This surgical technique is rarely used for abortions, but if it has to be done it is associated with a high rate of morbidity. With the increase in the incidence of previous uterine scars, the rate of placenta accreta spectrum has increased. Hysterotomy may be required in these cases.
A case report on tuberculosis in pregnancy revealing the need for an effective multidisciplinary approach and the importance of tailored therapy
Authors: Gandavaram Nishitha , Rajalekshmi M  
Published: August 2024

Tuberculosis (TB) during pregnancy, especially with central nervous system (CNS) involvement, poses significant risks to maternal and fetal health. This case report explores the diagnostic and therapeutic challenges of managing new-onset seizures in a pregnant patient with CNS-TB.A 23-year-old primigravida presented at 36 weeks gestation with new-onset seizures. The diagnostic workup, complicated by the pregnancy, revealed a left frontal tuberculoma. The patient was started on a standard antitubercular therapy (ATT) regimen of 2HRZE followed by 4HR, taking into account the drugs’ teratogenic potential and fetal safety. Despite the development of mild atonic postpartum hemorrhage (PPH), the patient gave birth to a preterm but viable infant with satisfactory APGAR scores.The interdisciplinary team provided comprehensive care, including seizure management with Levetiracetam and postpartum follow-up for both mother and child. The patient showed neurological improvement and, alongside the newborn, had a favorable outcome. This case underlines the importance of a tailored, multidisciplinary approach to managing TB in pregnancy. It also emphasizes the need for vigilant monitoring and treatment adherence to navigate the complexities of TB with CNS involvement and concurrent pregnancy.Enhanced prenatal screening for TB, interdisciplinary protocols, research on TB medications during pregnancy, and long-term follow-up studies are recommended to improve outcomes for similar future cases.
Higher education reputation management through increasing the role of public relations
Authors: Anggarina Paula Tjatoerwidya , Irawan Agustinus Purna , Dewi Fransisca Iriani Roesmala 
Published: August 2024

A university's reputation is an important factor in winning the competition and ensuring sustainability. The reputation built by a university must be about its vision and mission. Reputation needs to be managed professionally by an organization namely quality public relations as the spearhead in delivering and communicating information to all university stakeholders. This research aims to formulate how to manage the reputation of higher education by increasing the role of public relations. The research method used is a descriptive analysis method that combines surveys through questionnaires and in-depth interviews with stakeholders as the main informants. It can be concluded that public relations play an important role in managing higher education reputation based on the results of the research. The built reputation must be based on the values adopted because they become the guideline and direction of the college's development goals. A university's reputation is influenced by accreditation, quality of graduates, human resources, leadership, college rankings, facilities, curriculum, services, community service and innovation, publications and collaborations. Negative factors such as violence, bullying, plagiarism and diploma forgery have the potential to reduce reputation. In reputation management, public relation has a role as a liaison to stakeholders in conveying information about the reputation of higher education. Public relations must manage negative factors that can reduce reputation. The results of this study will be a reference for further research.
Understanding the mediating role of job satisfaction on the effect of organizational communication and organizational justice on intention to leave in banking sector
Authors: Santoso Lukman Arief Budi , Noermijati  
Published: August 2024

This study aims to investigate the impact of Organizational Communication and Organizational Justice on Intention to Leave, and to identify the mediation of Job Satisfaction in the said relationship.This study is a quantitative study and a questionnaire was distributed to Bank X Area Surabaya employees with a total of 203 respondents. The data analysis technique used the SEM-PLS analysis tool with the help of SmartPLS 4.0 software. The results of this study show that organizational communication has a negative and significant effect on intention to leave, organizational justice has a negative and insignificant effect on intention to leave, organizational communication has a positive and significant effect on job satisfaction, organizational justice has a positive and significant effect on job satisfaction, job satisfaction has a negative and significant effect on intention to leave and finally job satisfaction mediates the effect of organizational communication and organizational justice on intention to leave. This study provides valuable insight in the context of employee resistance and organizational conditions at a state-owned bank.

Keywords: Organizational Communication, Organizational Justice, Job Satisfaction, Intention to Leave
Social media marketing and performance of youth owned SMES in Nairobi County, Kenya
Authors: Teresia Kyalo  
Published: August 2024

Fast technological evolution and intensity of competition oblige companies to constantly seek for new ways to differentiate and offer added value to their customers. With the increasing popularity of social media, companies have started to consider this means as a new way to communicate with their customers and increase their brand reputation. One of the most notable phenomena of new media is how it has increased and created new forms of social interaction.In Kenya, despite the critical role played by the Small and Medium Enterprises (SMEs) in the country, research has shown that 90% business startups fail in their third year and especially those owned by the youths The general purpose of the study was to establish the influence of social media marketing on performance of small and medium businesses in Nairobi’s industrial area. This study adopted a descriptive research design. Official records of AGPO as at December 2023 showed that there are 13,011 youth-owned businesses registered in the county of Nairobi with the Youth Access to Government Procurement Opportunities Program (YAGPO). The study used the 10-30% Mugenda Sampling principle to calculate the sample size of 130 SMEs. The first specific objective was to establish the extent Social Media Platforms Influence the Performance of Small and Medium Enterprises. A Pearson correlation analysis was done to establish the relationship between social media platform on performance of SMEs and the result established a significant positive relationship between social media platform used and the performance of SMEs (r=.811, p value =0.000). The second specific objective was to establish the extent bloggers influence the performance of Small and Medium Enterprises. A Pearson correlation analysis was done to establish the relationship between blogger influence on performance of SMEs and the result established a significant positive relationship between blogger influence and the performance of SMEs (r=.730, p value =0.000). The third objective was to establish the extent social media messaging factors influence the performance of Small and Medium Enterprises. A Pearson correlation analysis was done to establish the relationship between messaging factors on performance of SMEs and the result established a significant positive relationship between social media messaging factors used and the performance of SMEs (r=.359, p value =0.000). The study concluded that use of social media marketing has a positive influence on performance of SMEs and recommended that there is need for SMEs to embrace the use of social media to market their products and that the government should support SMEs by providing affordable internet services.
Efficacy of pharmacological interventions for ADHD: protocol for an updated systematic review and dose-response network meta-analysis
Authors: Nourredine Mikail , JUREK Lucie , SALANTI Georgia , CIPRIANI Andrea , SUBTIL Fabien , EFTHIMIOU Orestis , HAMZA Tasnim , CORTESE Samuele 
Published: August 2024

Abstract

Background
Attention-Deficit/Hyperactivity Disorder (ADHD) affects approximately 5% of children globally, with symptoms often persisting into adulthood. While pharmacological interventions are commonly employed for management, understanding the optimal dosing for efficacy and tolerability remains crucial. This study aims to conduct a dose-response network meta-analysis to estimate the efficacy of pharmacological treatments across different doses, aiming to inform clinical decision-making and improve treatment outcomes.
Methods
This updated systematic review will include randomized controlled trials evaluating ADHD medication efficacy in children, adolescents, and adults. An updated search from a 2018 NMA will be conducted across multiple electronic databases with no language restrictions, using specific eligibility criteria focused on randomized controlled trials. The primary outcome will assess the severity of ADHD core symptoms, while secondary outcomes will consider treatment tolerability. A dose-response Bayesian hierarchical model will be used to estimate dose-response curves for each medication, identifying optimal dosing strategies.
Discussion
With this dose response network metanalysis we aim to better understand the dose-response relationship of pharmacological treatment in ADHD, which could help clinician to the identification of optimal doses.
Systematic review registration: OSF https://doi.org/10.17605/OSF.IO/3MY4A
Possible Linking and Treatment between Parkinson’s Disease and Inflammatory Bowel Disease: A Study of Mendelian Randomization Based on Gut–Brain Axis
Authors: Wang Beiming , Bai Xiaoyin , Yang Yingmai , Yang Hong 
Published: August 2024

Abstract

Background: Mounting evidence suggests that Parkinson’s disease (PD) and inflammatory bowel disease (IBD) are closely associated and becoming global health burdens. However, the causal relationshipsand common pathogeneses between them are uncertain. Furthermore, they are uncurable. Thus, we aimedto identify the causal relationships and novel therapeutic targets shared between them based on their common pathophysiological mechanisms in gut-brain-axis (GBA).
Methods: A meta-analysis on bidirectional Mendelian randomization (MR) utilizing various datasets was performed to estimate their causal relationship. Then, pleiotropicanalysis under the composite null hypothesis(PLACO) with functional mapping combined withannotation of genetic associations (FUMA) analysis were conducted to identify pleiotropic genes. Next, blood, brain and intestine expression quantitative trait locus (eQTL) were taken to perform drug-target MR finding common causal genes in two diseases. Colocalization analysis ensured the eQTLs of corresponding gene colocalized with disease. Enrichment analysis and protein‒proteininteraction (PPI) network were done to explorecommon pathogenesis pathways. Genes passed all analysis were regarded as drug targets.
Results: Our MR meta-analysis revealed thebidirectional causal relationship between diseases, with combined ORs for PD on IBD, CD, UC (1.050 [95% CI: 1.014-1.086], 1.044 [95% CI: 0.995-1.095], 1.063 [95% CI: 1.016-1.120]); for IBD, CD, UC on PD (1.003 [95% CI: 0.973-1.034], 1.035 [95% CI: 1.004-1.067], 1.008 [95% CI: 0.977-1.040]). Overall, 277, 216 and 201 genes were identified as pleiotropic genes between PD and IBD, CD, UC. Total of733 genes were classified as tier 3 (found in only one tissue) druggable targets, 57 as tier 2 (found in two tissues, 51 protein-coding genes) and 9 as tier 3 (found in three tissues). Among 60 protein-coding druggable targets over tier 2, 18 overlapped with pleiotropic genes and enriched in mitochondria, antigen presentation, processing and immune cell regulation pathways. Three druggable genes (LRRK2, RAB29 and HLA-DQA2) passed colocalization analysis. LRRK2 and RAB29 were reported to be pleiotropic genes, and RAB29 and HLA-DQA2were reported for the first time as potential drug targets.
Conclusions:
This study established areliable causal relationship, possible shared drug targets and common pathogenesis pathways of two diseases, which had important implications for intervention and treatment of two diseases simultaneously.
High efficiency sonochemical degradation of bisphenol A: a synergistic dual-frequency ultrasound approach
Authors: Symes Mark , Fletcher Shaun , Yusuf Lukman , Ertekin Zeliha 
Published: August 2024

Abstract

The persistence of bisphenol A in the environment poses significant ecological hazards. Traditional treatment methods often fall short in removing micropollutants such as bisphenol A from wastewater. The use of ultrasound in water treatment has the potential to induce powerful oxidative degradation of micropollutants while dispensing with the need for chemical intervention. Herein, we show a novel approach for the sonochemical degradation of bisphenol A using dual frequency ultrasound. The synergistic effects of using two distinct ultrasonic frequencies (20 kHz, with the addition of either 37 kHz or 80 kHz) were investigated in the context of bisphenol A removal and mineralisation. The method was shown to substantially increase the rate of degradation compared to single frequency treatment, achieving a 94.2% removal of bisphenol A under optimised conditions. The extent of mineralisation of the target pollutant and the absence of the need for chemical additives demonstrates the effectiveness of the method as a green alternative for water treatment.