bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Pain is not typically taken into consideration due to him being nonverbal”- emergency department experiences among persons with disabilities: a mixed methods study in Kingston, Ontario
Authors: Haque Minha , Gaspari Sierra , Bobbette Nicole , Walker Melanie , Bartels Susan A. 
Published: July 2024

BackgroundPersons with disabilities (PWD) are more likely to visit the emergency department (ED) and often have complex health needs when accessing care in the ED. Yet there is limited understanding of ED care experiences among PWD, especially in a Canadian context. The aim of this study was to examine the ED care experiences of PWD in contrast to a comparison group in Kingston, Ontario to better understand their health care needs.MethodsA mixed-methods study with a community-based participatory approach examining participants’ past ED care experiences (within 24 months) was conducted in Kingston, ON. Quantitative data from those with disabilities and those from the comparison group were compared using chi squared tests to identify differences between groups. An inductive and deductive thematic analysis approach was used to identify themes in the shared qualitative data. Convergence of findings across quantitative and qualitative data was undertaken.ResultsA total of 175 participants identified as having a disability. In contrast with the comparison group (N = 949), PWD were more likely to report being given too little attention to their needs (p &lt; 0.001), that it was more important to be treated with kindness/respect than to receive the best possible medical care (p &lt; 0.001), to report feelings of disrespect and/or judgement (p &lt; 0.001), and that better understanding of personal identity/situation/culture and better communication would improve ED care. Qualitative analysis highlighted the following themes: poor communication between PWD and health care providers (HCP), compassionate medical care received, perceived HCP negative attitudes/beliefs related to having a disability and substance misuse, and perceived HCP lack of knowledge/skill to treat the unique health needs of PWD.ConclusionFindings highlight the need to improve ED care for PWD. Future quality improvement initiatives should focus on incorporating a deeper understanding of disability into medical education and emergency medicine (EM) residency education, designing curricula that emphasize cultural humility, and implementing community-based placements providing opportunities for health professionals to work with and learn from PWD.
IL-26 Increases Sensing of Borrelia burgdorferi DNA by Human Toll-like Receptor 9
Authors: Taylor Andre , Griffin Chin , Arrington Kedzie , Barragan Jose , Cervantes Jorge 
Published: July 2024

Background: IL-26 has demonstrated antimicrobial properties, as well as in the degradation of DNA from the Lyme disease spirochete Borrelia burgdorferi (Bb). Additionally, IL-26 can promote macrophage activation and enhance Bb phagocytotic activity. It is unclear if cell-mediated immune responses are modulated through TLR9 signaling when exposed to IL-26 Bb DNA complexes in post-treatment Lyme disease syndrome (PTLDS). Objective: We here aim to explore the effect of IL-26 in human Toll-like receptor (TLR)-9’s activation upon the recognition of Bb DNA. Methods: We utilized a single-receptor cell system, HEK-Dual™ hTLR9 cells, which harbors two reporter plasmids for the NF-κB and IL-8 signaling pathways. Bb DNA was exposed to increasing concentrations of IL-26 in monomeric or dimeric form and then used to stimulate the cells for 4 h. The TLR-9 ligand CpG was used as a control. Results: We observed that NF-κB and IL-8 activation was maximal when the cells were stimulated with Bb DNA that had been treated with 5 µM of IL-26 monomer and 1 µM of IL-26 dimer. The same was observed for IL-8 activation upon CpG stimulation. We observed, however, a decrease in NF-κB activation when treated with either form of IL-26. An NF-κB activation increase did not occur with IL-26-treated TLR9 ligand CpG. Conclusions: Our study shows an enhancement in NF-κB and IL-8 activation upon the recognition of IL-26-treated Bb DNA by TLR9, which suggests an increase in sensing by the TLR9 of Bb DNA when it is in the form of an IL-26-Bb DNA complex. These findings will prompt further studies on the interaction between IL-26 and Bb DNA.
Nematicidal Activity of Volatiles against the Rice Root-Knot Nematode and Environmental Safety in Comparison to Traditional Nematicides
Authors: Faria Jorge M. S. , Rusinque Leidy , Inácio Maria L. 
Published: July 2024

The rice root-knot nematode (RRKN), Meloidogyne graminicola Golden and Birchfield 1965, is a dangerous crop pest that affects rice production on a global scale. The largest rice-producing countries struggle with the impacts of RRKN infestation, namely, underdeveloped plants and a reduction in rice grain that can reach up to 70% of crop yield. In addition, the shift to strategies of sustainable pest management is leading to a withdrawal of some of the most effective pesticides, given the dangers they pose to the environment and human health. Volatile metabolites produced by plants can offer safer alternatives. The present study characterized the nematicidal activity of volatile phytochemicals against the RRKN and compared the most active with commercial nematicides concerning their safety to the environment and human health. Rice plants were used to grow large numbers of RRKNs for direct-contact bioassays. Mortality induced by the volatiles was followed for four days on RRKN second-stage juveniles. Of the 18 volatiles tested, carvacrol, eugenol, geraniol, and methyl salicylate showed the highest mortalities (100%) and were compared to traditional nematicides using (eco)toxicological parameters reported on freely available databases. While methyl salicylate had a faster activity, carvacrol had more lasting effects. When compared to synthetic nematicides, these volatile phytochemicals were reported to have higher thresholds of toxicity and beneficial ecotoxicological parameters. Ultimately, finding safer alternatives to traditional pesticides can lower the use of damaging chemicals in farming and leverage the transition to agricultural practices with a lower impact on biodiversity.
Hyperkalemia Burden and Treatment Pathways in Patients with CKD: Findings From the DISCOVER CKD Retrospective Cohort
Authors: Fishbane Steven , Carrero Juan-Jesus , Kumar Supriya , Kanda Eiichiro , Hedman Katarina , Ofori-Asenso Richard , Kashihara Naoki , Kosiborod Mikhail N. , Lainscak Mitja , Pollock Carol , Stenvinkel Peter , Wheeler David C. , Pecoits-Filho Roberto 
Published: July 2024

Key Points

Hyperkalemia (HK) is associated with increased comorbidity burden in patients with CKD.Reducing serum potassium levels after HK episodes helps continuation of renin-angiotensin-aldosterone system inhibitor treatment.In Japan, HK treatment pathways are more heterogeneous and potassium binders are more commonly prescribed compared with the United Kingdom.

Background
This analysis used retrospective data from the DISCOVER CKD observational study (NCT04034992) to describe the burden of and treatment pathways for hyperkalemia (HK) in patients with CKD.

Methods
Data were extracted from the following databases: UK Clinical Practice Research Datalink (2008–2019) and Japan Medical Data Vision (2008–2017). Patients with CKD (two eGFR measures <75 ml/min per 1.73 m2 recorded ≥90 days apart) and HK (at least two serum potassium [sK+] measures >5.0 mmol/L) were compared with patients without HK (sK+ <5.0 mmol/L); HK index event was the second sK+ measurement. Outcomes included baseline characteristics and treatment pathways for key medications (renin-angiotensin-aldosterone system inhibitors [RAASi], diuretics and potassium [K+] binders).

Results
In the UK Clinical Practice Research Datalink, 37,713 patients with HK and 142,703 patients without HK were included for analysis (HK prevalence 20.9%). In the Japan Medical Data Vision, 5924 patients with HK and 74,272 patients without HK were included for analysis (HK prevalence 7.4%). In both databases, median eGFR was lower and comorbidities such as hypertension, heart failure, type 2 diabetes, and AKI were more prevalent among patients with versus without HK, and most patients were taking RAASi at the time of HK index. Treatment pathways were more heterogeneous in Japan; <0.2% of patients with CKD and HK in the United Kingdom initiated K+ binders within 3 months of HK index versus 18.7% in Japan. The proportions of patients with CKD and HK who stopped treatment with diuretics, K+ binders, and RAASi during follow-up were 48.7%, 76.5%, and 50.6%, respectively, in the United Kingdom, and 22.9%, 53.6%, and 29.2%, respectively, in Japan.

Conclusions
HK was associated with increased comorbidity burden in patients with CKD. Variations in treatment pathways between the United Kingdom and Japan reflect the previous lack of a standardized approach to HK management in CKD.
Major Changes in the Socio-Labor Space of the Republic of Tyva
Authors: Самба А.Д. 
Published: July 2024

В статье анализируется социально-трудовое пространство Республики Тыва, которое претерпевает существенные изменения в отраслевой и профессионально-квалификационной структуре занятого населения. На основе анализа статистических данных и публикаций специалистов по данной теме автор показал, что несмотря на в целом положительные сдвиги в струтуре предложения труда, структура спроса на него остается довольно традиционной. Основными сдерживающими факторами, по мнению автора, являются социокультурные и экономико-географические особенности развития региона. В то же время очевидной является несогласованность приоритетных направлений развития и, как следствие, взаимодействия институтов, отвечающих за это.
The article analyzes the social and labor space of the Republic of Tyva, which is undergoing significant changes in the sectoral and professional-qualification structure of the employed population. On the basis of the analysis of statistics and publications of the experts, the author shows that despite the generally positive changes in the structure of labor supply, the structure of demand for it remains quite traditional. According to the authors opinion, the main restraining factors are socio-cultural and economic-geographical features of the regional development. At the same time, it is obvious that there is a lack of coordination of priority directions of development and, as a consequence, ineffective interaction of the institutions responsible for this.
Electoral Campaigns of Autumn 2019 and Political Parties: Problems of Effective Participation
Authors: Дорожкин Ю.Н. , Евдокимов Н.А. 
Published: July 2024

Статья посвящена проблемам эффективного участия политических партий в электоральных кампаниях. Подчеркивается малозаметный вклад региональных отделений партий в выборы глав регионов и представительных органов субъектов Российской Федерации в 2019 году. Выявляются причины слабой электоральной активности политических партий, а также условия повышения их роли в модернизации политической системы и усиления активности в электоральных процессах.
The article is devoted to the problems of effective participation of political parties in electoral campaigns. The subtle contribution of the regional branches of the parties to the elections of the heads of regions and representative bodies of the constituent entities of the Russian Federation in 2019 is emphasized. The reasons for the weak electoral activity of political parties are identified, as well as the conditions for increasing their role in the modernization of the political system and increased activity in electoral processes.
Managing Project Communications
Authors: Магомедбеков Г.У. , Абдуллаева Д.А. 
Published: July 2024

В статье раскрывается значимость управления проектными коммуникациями, рассматриваются преимущества эффективного управления коммуникациями для организации. Анализируются различные методы, а также программное обеспечение, способствующие эффективной передаче информации.
The article reveals the importance of managing project communications, the benefits of effective communications management for an organization are considered. Various methods, as well as software, that contribute to the effective transmission of information are analyzed.
Search for Alternative Social Policy Options: the Idea of ​​Universal Basic Income
Authors: Ибрагимова З.Ф. 
Published: July 2024

Статья посвящена теоретическим вопросам развития социальной концепции универсального базового дохода населения. Уделено особое внимание генезису и эффектам внедрения этого механизма. Рассмотрен зарубежный опыт реализации пилотных программ ввода универсального базового дохода. Определены преимущества, недостатки и условия реализации этой социальной концепции.
The article is devoted to theoretical issues of development of the social concept of universal basic income of the population. Special attention is paid to the genesis and effects of implementing this mechanism. The foreign experience of implementing pilot programs for the introduction of universal basic income is considered. The advantages, disadvantages and conditions for the implementation of this social concept are defined.
Strategic Directions for Improving the Quality of Life of Older People
Authors: Кандаурова И.Р. 
Published: July 2024

В статье раскрываются ключевые направления решения задачи по повышению качества жизни населения старшего поколения в России на долгосрочную перспективу. На основе изучения стратегий социально-экономического развития 14 регионов Приволжского федерального округа выявлены общие черты (схожие направления), а также отличительные региональные особенности в обеспечении активного долголетия данной группы населения.
The article reveals the key areas for solving the problem of improving the quality of life of the population of the older generation in Russia for the long term. Based on the study of socio-economic development strategies of 14 regions of the Volga Federal District, common features (similar directions), as well as distinctive regional features in ensuring the active longevity of this population group, are revealed.
Development of the Hotel Business in the Region under the Influence of the Seasonality Factor
Authors: Вишневская Н.Г. , Хамадеева З.А. , Борнеман Е.П. 
Published: July 2024

В статье рассмотрены вопросы развития гостиничного бизнеса как ключевой отрасли туристической индустрии. Определена роль гостиничной отрасли в экономике региона и влияние фактора сезонности на ее развитие. Авторы рассматривают виды и первопричины сезонов, дают практические рекомендации по снижению влияния различных сезонов на конечный результат деятельности гостиничного предприятия.
The article deals with the development of the hotel business as a key branch of the tourism industry. The role of the hotel industry in the regional economy and the influence of the seasonality factor on its development are determined. The authors consider the types and root causes of seasons, give practical recommendations to reduce the impact of different seasons on the final result of the hotel business.
Economic Space: Approaches to Research and Architectures
Authors: Гришин К. Е. , Казакова О. Б. , Кузьминых Н. А. , Тимирьянова В. М. 
Published: July 2024

В статье исследуются подходы к определению категорий «экономическое пространство» и «пространственная организация», обосновывается недостаточность оперирования в современных исследованиях только территориальным подходом. Предложены рекомендации по формированию нового подхода в региональных исследованиях, предусматривающие смещение приоритетов рассмотрения экономического пространства с макроуровня на микроуровень. Визуализируется экономическое пространство РФ, представленное как совокупность муниципальных образований, размер экономик которых определяется численностью населения, а их результативность – объемами отгруженной продукции работ и услуг.
The article explores approaches to the definition of the categories of «economic space» and «spatial order». The advantages of avoiding the territorial approach are determined. Recommendations on the formation of a new approach in regional studies are proposed, providing for a shift in the priorities for considering the economic space from the macro level to the micro level. The economic space of the Russian Federation is visualized, in the frame of which municipalities are displayed. The size of the economies of municipal formations is determined by the population, and their effectiveness is determined by the volumes of shipped products of work and services.
Methods of Flexible Practices as a Factor in the Effectiveness of the Organization
Authors: Фалеева Лия Владимировна 
Published: July 2024

В статье анализируются методы гибких практик (спринт, кросс-функциональные команды, Scrum-встречи, Канбан, Timeboxing), дается характеристика каждого метода, анализируются их возможности в реализации корпоративных проектов с целью повышения эффективности деятельности организаций.
The article analyzes the methods of flexible practices (sprint, cross-functional teams, Scrum-meetings, Kanban, Timeboxing), gives a description of each method, analyzes their capabilities in implementing corporate projects in order to increase the efficiency of organizations.
Digital Economy and its Role in the Development of the Labor Market: Trends and Prospects
Authors: Габидуллина Гульнара Рафаэлевна , Лужнева Алиса Михайловна , Феденко Ульяна Алексеевна 
Published: July 2024

В статье рассматривается актуальная проблема влияния цифровой экономики на развитие современ- ного рынка труда, анализируются последствия, получаемые в результате перехода общества к цифро- вой экономике. Рассмотрены различные методологические подходы к исследуемому явлению, сформули- рованы основные выводы.
The article deals with the actual problem of the impact of the digital economy on the development of the modern labor market, analyzes the consequences resulting from the transition of society to the digital economy. Various methodological approaches to the phenomenon under study are considered, and the main conclusions are formulated.
Volatility of Mortality Rates in the Republic of Bashkortostan: Socio-economic Factors
Authors: Франц Марина Валерьевна , Егорова Наталья Николаевна 
Published: July 2024

В статье выполняется факторный анализ волатильности показателя смертности от новообразований в разрезе муниципальных районов и городских округов Республики Башкортостан с применением гео- графически взвешенной регрессии. Географически взвешенная регрессия принадлежит к относительно новому направлению в экономической аналитике – пространственной эконометрике, основанной на учете географической информации об исследуемом объекте и его окружении. В целом наши расчеты доказывают пространственную неоднородность силы влияния факторов на смертность от новообра- зований, что должно учитываться при формировании социально-экономической политики на муници- пальном уровне.
The article deals with factor analysis of the volatility of cancer mortality rate among municipal areas of the Republic of Bashkortostan using a geographically weighted regression model. Geographically weighted regression belongs to a relatively new area in economic analytics – spatial econometrics based on the use of geographic information about an object and its environment. In general, our calculations confirm the spatial heterogeneity of the significance of factors affecting the level of cancer mortality, which must be taken into account while developing social and economic policies at the municipal level.
Actual Problems of Development of Digital Literacy of the Population
Authors: Дулясова Марина Веденеевна , Ханнанова Татьяна Рашитовна , Степанова Разифа Раисовна , Гарифуллина Альбина Фатиховна 
Published: July 2024

В статье рассматриваются актуальные проблемы развития цифровой грамотности населения в Республике Башкортостан. В нашем государстве реализуется программа «Цифровая экономика Российской Федерации», призванная содействовать вхождению России в пятерку государств-мировых лидеров. Одним из направлений развития цифровой экономики является повышение цифровой грамотности населения. Авторы статьи предлагают оригинальные индикаторы цифровой грамотности населения и показывают не только положительные, но и отрицательные последствия повышения уровня цифровой грамотности.
The article deals with actual problems of digital literacy development in the Republic of Bashkortostan. Our country is implementing the program «Digital economy of the Russian Federation», designed to promote Russia's entry into the top five world leaders. One of the directions of development of the digital economy is to increase the digital literacy of the population. The authors of the article offer original indicators of digital literacy of the population and show not only positive, but also negative consequences of increasing its level of digital literacy.
Industrialization Policy: History and Present
Authors: Каюмова Альфира Фарвазовна 
Published: July 2024

В данной статье рассмотрены сущность и актуальные проблемы индустриализации. Особое внимание уделяется соотношению индустриализации, новой индустриализации, деиндустриализации, в историческом аспекте рассматриваются вопросы развития производств пятого и шестого технологических укладов. Выделяются и описываются характерные особенности индустриализации в годы первых пятилеток на примере Башкортостана. На основании анализа обосновывается мысль о том, что опыт проведения форсированной индустриализации 1920–1930-х гг., сыгравшей большую роль в социально-экономическом развитии Республики Башкортостан, был бы полезен и в настоящее время при проведении в стране новой индустриализации.
This article discusses the nature and urgent problems of industrialization. Particular attention is paid to the ratio of industrialization, new industrialization, deindustrialization. In the historical aspect, the issues of development of production of the fifth and sixth technological structures are considered. The characteristic features of industrialization in the years of the first five-year plans are highlighted and described using the example of Bashkortostan. Based on the analysis, the idea is substantiated that the experience of accelerated industrialization of the 1920–1930s, which played a large role in the socio-economic development of the Republic of Bashkortostan, would be useful at the present time when a new industrialization is being carried out in the country.
Oath as a Social Institution Forms of Overcome Opportunistic Behavior
Authors: Габитов И.М. , Мажитова С.К. , Шарафуллина Р.Р. 
Published: July 2024

В данной статье рассматривается понятие оппортунистического поведения как экономической категории с позиции институциональной теории. Оппортунистическое поведение сводится в основном к уклонению от условий сделки для получения собственной выгоды, к преимущественному следованию собственным корыстным интересам часто в ущерб общественным. Авторы рассматривают значение и роль торжественного слова (клятвы, присяги, обещания) как социально-экономического общественного института для решения проблемы оппортунизма. Выявлены закономерные условия возникновения оппортунизма при заключении контракта и клятвы как одного из факторов доверия и преодоления недобросовестного оппортунистического поведения.
The authors consider the meaning and role of the solemn word (oath, oath, promise) as a socio-economic social institution for solving the problem of opportunism. The main conditions for the emergence of opportunism of a contract are revealed and an oath becomes one of the factors of trust and overcoming unfair opportunistic behavior.