bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic bullous disease of childhood – A case report / Hronična bulozna bolest Kod Dece – Prikaz Slučaja
Authors: Gocev Đorđi , Damevska Katerina , Nikolovska Suzana , Pavlova Ljubica , Petrova Nada 
Published: February 2013

Abstract
Linear IgA bullous dermatosis is a chronic, acquired, autoimmune subepidermal vesiculobullous disease. Both children and adults are affected. It is characterized by direct immunofluorescence findings of linear immunoglobulins class A (IgA) deposits along the dermal-epidermal junction (basement membrane zone). In children, the disease is commonly referred to as chronic bullous disease of childhood and it mostly affects children between 2 and 5 years. The onset of the disease is acute; the first episode is the most severe, while recurrences tend to wax and wane in severity and last till puberty or even longer. Diaminodiphenylsulfone is the treatment of choice, although systemic corticosteroids are reported to be very effective as well. We report a 3-year-old boy with a vesiculobullous eruption which developed one week following administration of cephalexin for upper respiratory infection. He was referred to our Clinic from other health institutions as treatment failure for suspected strophulus or impetigo bullosus. On admission, the patient had fever and numerous vesiculobullous and erosive lesions distributed on the face and trunk. After immunohistological verification, the treatment with prednisone 25 mg/d was introduced, due to rapid progression of the disease and the fact that diaminodiphenylsulfone was not available. Improvement occurred after 2 weeks, so the dose was carefully tapered, taking into account the possibility of adrenal suppression. The medication was completely excluded within the next three months. No serious side effects were observed, except transitory hirsutism. The patient has had no relapses over the last 20 months of clinical follow-up.
Basal Cell Carcinoma: A Frequent Challenge / Bazocelularni karcinom: čest izazov
Authors: Roš Tatjana , Gajić Branislava , Ivkov-Simić Milana , Gajinov Zorica 
Published: February 2013

Abstract
Basal cell carcinoma is a slow-growing, malignant epidermal tumor predominantly affecting sun exposed areas in Caucasians, accounting for up to 80% of all diagnosed skin cancers, with a rising incidence. Chronic UV radiation, in association with constitutional factors, plays the main role in its etiology. Inappropriate activation of the hedgehog signaling pathway seems to be a key pathogenesis mechanism. Basal cell carcinoma metastases are extremely rare, but it is a locally invasive tumor that can cause significant destruction of the surrounding tissues, with their functional and esthetic impairment. There are four main clinical types of basal cell carcinoma, although clinical classification is of poor prognostic significance. Preselection of suspicious lesions and treatment planning include noninvasive diagnostic techniques: dermoscopy, confocal microscopy and ultrasoud imaging, yet histopathology remains the “gold standard” of basal cell carcinoma diagnosis. In terms of the histological growth pattern, which is essential for the prognosis, basal cell carcinoma may be divided into circumscribed or diffuse types. Surgical excision is considered to be a first line treatment option, but there are numerous less invasive treatment modalities for low-risk basal cell carcinoma. Prevention strategies are focused on behavioral modifications, regular follow up and use of chemopreventive agents in high-risk patients.
Cutaneous Adverse Drug Reactions / Dematološka neželjena dejstva lekova
Authors: Kandolf-Sekulović Lidija , Radević Tatjana 
Published: February 2013

AbstractAdverse drug reactions may be defined as undesirable clinical manifestations resulting from administration of a particular drug; this includes reactions due to overdose, predictable side effects, and unanticipated adverse manifestations. Adverse drug effects on the skin are among the most frequent reactions and, according to a study, account for approximately 14% of all adverse drug reactions. However, the incidence of cutaneous adverse effects in general population is unknown. Systemic drug administration results in various cutaneous adverse reactions, and medications used in the treatment of skin diseases themselves have their own adverse effects. Adverse drug reactions include a wide range of effects, from harmless exanthema of short duration, urticaria to systemic cutaneous reactions such as drug rash with eosinophilia and systemic symptoms (DRESS) or toxic epidermal necrolysis. Exanthematous eruptions and urticaria are the two most common forms of cutaneous drug reactions. Less common include fixed eruptions, lichenoid, pustular, bullous and vasculitis reactions. The most severe cutaneous and mucosal adverse drug reactions are epidermal necrolysis, which is usually drug-induced, DRESS syndrome, and acute generalized exanthematous pustulosis. Therefore, the diagnostic of adverse drug reactions requires a detailed history of drug intake and development of skin disorders, excellent knowledge of clinical presentations for a wide range of drug-induced skin reactions as well as of the very medications being taken by patients. In addition to details on drug intake, it is necessary to learn about taking herbal and alternative preparations, which may also cause adverse reactions. A drug started within 6 weeks of the development of disorders is considered the most common cause of adverse reaction, as well as drugs taken periodically but regularly. Once a reaction has occurred, it is important to prevent future similar reactions with the same drug or a cross-reacting medication. Early withdrawal of all potentially responsible drugs is essential, particularly in case of severe drug reactions.
The first observation of the Levant sparrowhawk Accipiter brevipes (Severtzov, 1850) in Slovakia
Authors: Danko Štefan , Hrtan Ervín 
Published: February 2013

Abstract
On May 1 5, 201 2 an individual of Levant sparrowhawk Accipiter brevipes was observed at the southern edge of Trebišov town in eastern Slovakia, situated in the Východoslovenská rovina Lowlands. The sighting was documented with photographs. This is the first recorded occurrence of this species in terms of the bird fauna of Slovakia. The present article describes in detail its distribution and breeding in eastern Hungary and western Romania, based on an isolated population in the Pannonian Basin at the north-western edge of its breeding range. The occurrence of the Levant sparrowhawk beyond the boundaries of its breeding range and outside the Pannonian Basin consists mostly of rare movements by young individuals (northern Moravia, central and northern Poland) far north of its breeding range. An adult male was observed in south-eastern Poland in the pre-breeding period, and in Slovakia an adult female was observed in the breeding period.
Non-linear optimization of high-pressure gas networks with respect to hydrate control / Nieliniowa optymalizacja sieci gazowej wysokiego ciśnienia z uwzględnieniem zapobieganiu hydratów
Authors: Osiadacz Andrzej J. , Uilhoorn Ferdinand E. , Chaczykowski Maciej 
Published: February 2013

Abstract
In this paper, gas pipeline optimization includes constraints resulting from hydrate prevention. The key is to seek for the optimal settings of both: the compressor units and hydrate combating method at minimum fuel consumption subject to security of supply and hydrate prevention. A case study is conducted on the Polish section of the Yamal pipeline and an arbitrarily selected partial onshore and offshore pipeline. Three different configurations are investigated: (i) cooling the compressed gas, (ii) no cooling and (iii) line heating immediately after the compressor station. For each configuration, the fuel consumption of the compressors is minimized and in order to prevent hydrate formation, the outlet temperature of the line heater, allowable water vapour in the gas and methanol concentration are calculated for each pipe section. The hydrate model is based on the statistical mechanical approach of Van der Waals and Platteeuw and applicable for systems that contain water (free or dissolved in gas), methanol and mixed gases both hydrate and non-hydrate formers.
Focal Mechanisms of Mine-Induced Seismic Events an Explanation of Geomechanical Processes in the Area of Longwall 6, Seam 510 In Hard Coal Mine “Bobrek-Centrum” / Mechanizm Ognisk Indukowanych Wstrząsów Górniczych Wyjaśnieniem Procesów Geomechanicznych W Rejonie Ściany 6, Pokład 510 W Kopalni „Bobrek-Centrum”
Authors: Stec Krystyna 
Published: February 2013

Abstract
Exploitation in a coal mine “Bobrek-Centrum” of the longwall 6 in seam 510 has led to the occurrence of very high seismic activity. From January 2011 to June 2012 took place almost 3500 tremors with the energy of 102-104 J and 95 tremors of energy more than to 105 J. In an attempt to identify the character of that seismicity, calculations of focal mechanism parameters were carried out, and according to them local stress field was determined. Three periods of exploitation of longwall 6 were distinguished which vary in type of focal mechanism. Tremors, which occurred in exploitation periods I and III were characterized by normal slip mechanism, occurred due to domination of vertical principal stresses σ1, horizontal intermediate stresses σ2 and minimal ones σ3. Such stress arrangement characterizes local state of rock mass behaviour as a result of cracking and collapse of sandstone, tremor-generating strata during advancing exploitation. In exploitation period II, of non-shearing mechanism of foci occurred. That was the period of change of longwall run from the NE-SW direction to E-W direction, that is the period of so called “slanting” of exploitation front. It can be presumed that this type of tremor mechanism could have occurred due to a sudden coal bed load by superimposed roof strata, which may have led to extreme load conditions and to a dynamic disintegration of seam part. It was confirmed by geomechanical calculations, which indicated that in the region of rockburst existence on 19.07.2011, layers which were located above and under seam 510 in area of longwall no. 6 were strongly deformed locally causing compression of certain parts of seam.
The Law of Effective Stress for Rocks in Light of Results of Laboratory Experiments / Prawo Naprężeń Efektywnych Dla Skał W Świetle Wyników Badań Laboratoryjnych
Authors: Nowakowski Andrzej 
Published: February 2013

Abstract
This paper presents the results of laboratory tests carried out in order to formulate effective stress law. The law was sought for two different cases: first - when rock was treated as a porous Biot medium (Biot, 1941; Nur & Byerlee, 1971) and second - when the law was formulated according to definition of Robin (1973) developed by Gustkiewicz (1990) and Nowakowski (2007). In the first case coefficents (4) and (5) of the Biot equation (3) were were determined on the basis of compressibility test, in the second one effective pressure equation (9) and effective pressure value (11) were found on the basis of results of so called individual triaxial compression test (see Kovari et al., 1983) according to the methodology given by Nowakowski (2007).
On the basis of Biot coefficients set of values was found that volumetric strain of the pore space described by a coefficient (5) was not dependent on the type of pore fluid and the pore pressure of only, while in case of volumetric strain of total rock described by coefficient (4) both the structure and texture of rock were important.
The individual triaxial compression test results showed that for tested rock an effective pressure equation was a linear function of pore pressure as (15). The so called Rebinder effect (Rehbinder & Lichtman, 1957) might cause, that the α coefficient in equation (15) could assume values greater than one. This happened particularly in the case when the porous fluid was non-inert carbon dioxide.
In case of inert pore fluid like kerosene the test results suggested that the a coefficient in equation (15) decreased while the differential strength limit was increasing. This might be caused by, so called, dillatancy strengthening (see Zoback & Byerlee, 1975).
Another considered important parameter of the equation (15) was the value of the effective press p'. The results showed that the value of this parameter was practically independend on the pore fluid type. This conclusion was contrary to previous research (see, for example, Gustkiewicz et al., 2003 and Gustkiewicz, 1990) so these results should be treated with caution. There are no doubts, however, over p' increasing simultaneously with increase in Rσ1-σ3. Basically, the differential strength limit of the specimen is greater the greater is confining pressure applied to it. Thus, higher Rσ1-σ3 values are accompanied by higher p'.
Selection of the Longwall Face Crew with Respect to Stochastic Character of the Production Process – Part 1 – Procedural Description / Wyznaczanie Obsady Przodka Ścianowego Z Uwzględnieniem Stochastycznego Charakteru Procesu Produkcyjnego. Cz. 1 – Opis Metody
Authors: Snopkowski Ryszard , Sukiennik Marta 
Published: February 2013

Abstract
A proposal of the method aimed at the longwall face crew selection with respect to stochastic character of the production process has been described in this study. Modules, which can be isolated from the production cycle, as well as methods of determination of the probability function density describing duration of individual action realized in production process, have been described in the first part of the study.
Procedure of crew selection of individual modules, including optional crew selection, has been described in next chapters. Statement of action, which should be executed in order to apply the proposed method, including final conclusions, is discussed in the last chapter.
Lichens from two inland localities in west Greenland and their climatic preferences
Authors: Hansen Eric Steen 
Published: February 2013

Abstract
Hansen E. S., 2012: Lichens from two inland localities in West Greenland and their climatic preferences [Kerpės iš dviejų vidinių vakarinės Grenlandijos vietovių bei jų klimatinės preferencijos]. - Bot. Lith., 18(1): 19-26. In total, 143 lichen taxa collected from two inland localities in West Greenland are reported and categorized toward their climatic preferences in Greenland. Eighty three lichen taxa were collected in Eqaluit ilorliit in the Ameralik Fjord area in 2000 and 120 lichen taxa were collected in Utaap kuua, east of Sisimiut, in 1998. The two localities share 58 lichen taxa. Almost three fourths of the 143 lichens are more or less equally distributed in continental and oceanic areas in Greenland. About one sixth of the lichens occur most frequently in oceanic areas and more rarely in continental areas, while less than one tenth of the lichens occur frequently in continental areas and more rarely in oceanic areas. The climate of the two localities is low arctic, oceanic. Although they are situated at some distance from the outer coast and close to the continental zone, they are poor in lichens with a mainly continental distribution in Greenland compared to, for example, Kangerlussuaq, which is located in the continental inland region in the southernmost West Greenland.
A Contribution to the Lichen Flora of North East Greenland
Authors: Hansen Eric Steen 
Published: February 2013

Abstract
Hansen E. S., 2012: A contribution to the lichen flora of North East Greenland [Papildomi duomenys apie šiaurės rytų Grenlandijos florą]. - Bot. Lith., 18(2): 109-116.
The paper lists 83 species of lichens from North East Greenland between 75° and 80°N. A little more than half of the species, viz. 45, were recorded for the first time from this region. Fell-field lichens from alkaline and neutral as well as slightly acid ground are presented in the material, which, however, also contains some species of lichens found growing in moist heath localities as well as those with snow patches. The material includes numerous saxicolous lichens from siliceous bird rocks and rocks without visible influence of guano including some alkaline rocks.
Longitudinal volumetric MRI study of pituitary gland following severe traumatic brain injury
Authors: Craciunas Sorin C. , Cirstea Carmen M. , Yeh Hung-Wen , Hutfles Lewis , Lierman Joann , Schmitt Allan , Brooks William M. 
Published: February 2013

AbstractPurpose: Previous studies have suggested that the hypopituitarism following traumatic brain injury (TBI) is more prevalent than traditionally thought. The objective of this study was to characterize longitudinal MRI morphometric changes of pituitary gland in patients with severe TBI.Materials and methods: Fourteen patients who had suffered a severe TBI (Glasgow Coma Score=3 - 8) underwent MRI at three time points: Time 1 (mean=31. 5 days), Time 2 (98. 0) and Time 3 (185. 5). The pituitary gland volume was quantified by manually tracing on T1-weighted magnetic resonance images. Data from TBI patients were compared to 14 age- and sexmatched uninjured controls. The relationships between pituitary volumetric measures and patient demographics, length of respiratory support and coma, and presence of intracranial hemorrhage or skull fractures were also analyzed.Results: Following TBI, the pituitary volumes were significantly greater at all three time points: Time 1: median=665mm3, range=460-830mm3, p=0. 007; Time 2: 694mm3, 467-866mm3, 0. 007; and Time 3: 655mm3, 444- 795mm3, 0. 015, compared with controls (504mm3, 433-591mm3). At Time 1, pituitary volume was increased in 10 out of 14 patients. Of these, early pituitary enlargements persisted up to six months in nine patients. Pituitary enlargements were negatively correlated with GCS, but not with other variables.Conclusion: Following a severe TBI, early pituitary enlargement found in most of our patients persisted in the chronic phases. Our data suggest a potential role of MRI morphometry in early prediction of pituitary dysfunction following head trauma, but further studies including hormonal measurements are necessary for validation.
Kinetic Profiles and Management of Hepatitis B Virus Reactivation in Patients With Immune‐Mediated Inflammatory Diseases
Authors: Droz Nina , Gilardin Laurent , Cacoub Patrice , Berenbaum Francis , Wendling Daniel , Godeau Bertrand , Piette Anne‐Marie , Dernis Emmanuelle , Ebbo Mikael , Fautrel Bruno , Le Guenno Guillaume , Mekinian Arsène , Bernard‐Chabert Brigitte , Costedoat‐Chalumeau Nathalie , Descloux Elodie , Michot Jean‐Marie , Radenne Sylvie , Rigolet Aude , Rivière Sophie , Yvin Jean‐Luc , Thibault Vincent , Thabut Dominique , Pol Stanislas , Guillevin Loïc , Mouthon Luc , Terrier Benjamin 
Published: February 2013

ObjectiveImmunosuppressive therapy may trigger hepatitis B virus (HBV) reactivation for increased morbidity and mortality. We aimed to describe HBV reactivation in patients receiving treatment for immune‐mediated inflammatory diseases (IMIDs) and to evaluate a predefined algorithm for its prevention.MethodsPhysicians submitted data for patients receiving treatment for IMIDs and exhibiting HBV reactivation, defined as an increase of >1 log10 IU/ml of HBV DNA levels or DNA reappearance. We systematically reviewed cases in the literature.ResultsThe 35 physician‐collected patients had rheumatoid arthritis (n = 14), connective tissue disease (n = 7), vasculitis (n = 5), and other diseases (n = 9). At baseline, 65.7% of patients were positive for hepatitis B surface antigen (HBsAg), 31.4% had a history of HBV infection, and 2.9% had occult HBV infection. Reactivation occurred a median of 35 weeks (range 2–397 weeks) after the start of corticosteroid and/or immunosuppressive therapy. In all, 88.6% of patients were clinically asymptomatic, but 25.7% had severe hepatitis; none had fulminant hepatitis. Management was antiviral therapy for 91.4%, with discontinuation or decrease of immunosuppressive therapy for 45.7%. In pooling these 35 cases and 103 patients from the literature, 73.9% of patients were clinically asymptomatic, 33.3% had severe hepatitis, and 12.3% died and/or had fulminant hepatitis. Reactivation occurred early with rituximab or cyclophosphamide therapy and in HBsAg‐positive/HBV DNA–positive patients. Using the predefined algorithm, 78% of patients with reactivation would have received preemptive antiviral therapy.ConclusionWe provide new insights into HBV reactivation in patients receiving treatment for IMIDs. A predefined algorithm may be effective in reducing the risk of HBV reactivation in this population.
In Vivo Cyclic Compression Causes Cartilage Degeneration and Subchondral Bone Changes in Mouse Tibiae
Authors: Ko Frank C. , Dragomir Cecilia , Plumb Darren A. , Goldring Steven R. , Wright Timothy M. , Goldring Mary B. , van der Meulen Marjolein C. H. 
Published: February 2013

ObjectiveAlterations in the mechanical loading environment in joints may have both beneficial and detrimental effects on articular cartilage and subchondral bone, and may subsequently influence the development of osteoarthritis (OA). Using an in vivo tibial loading model, the aim of this study was to investigate the adaptive responses of cartilage and bone to mechanical loading and to assess the influence of load level and duration.MethodsCyclic compression at peak loads of 4.5N and 9.0N was applied to the left tibial knee joint of adult (26‐week‐old) C57BL/6 male mice for 1, 2, and 6 weeks. Only 9.0N loading was utilized in young (10‐week‐old) mice. Changes in articular cartilage and subchondral bone were analyzed by histology and micro–computed tomography.ResultsMechanical loading promoted cartilage damage in both age groups of mice, and the severity of joint damage increased with longer duration of loading. Metaphyseal bone mass increased with loading in young mice, but not in adult mice, whereas epiphyseal cancellous bone mass decreased with loading in both young and adult mice. In both age groups, articular cartilage thickness decreased, and subchondral cortical bone thickness increased in the posterior tibial plateau. Mice in both age groups developed periarticular osteophytes at the tibial plateau in response to the 9.0N load, but no osteophyte formation occurred in adult mice subjected to 4.5N peak loading.ConclusionThis noninvasive loading model permits dissection of temporal and topographic changes in cartilage and bone and will enable investigation of the efficacy of treatment interventions targeting joint biomechanics or biologic events that promote OA onset and progression.