bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic compact data structure for temporal reachability with unsorted contact insertions
Authors: Fernando Afra Brito Luiz , Keese Albertini Marcelo , Augusto Nassif Travençolo Bruno , Navarro Gonzalo 
Published: July 2024

Abstract
Temporal graphs represent interactions between entities over time. Deciding whether entities can reach each other through temporal paths is useful for various applications such as in communication networks and epidemiology. Previous works have studied the scenario in which addition of new interactions can happen at any point in time. A known strategy maintains, incrementally, a Timed Transitive Closure using a dynamic data structure composed of $O(n^{2})$ binary search trees containing non-nested time intervals. However, space usage for storing these trees grows rapidly as more interactions are inserted. In this paper, we introduce a compact data structure that represents each tree as two dynamic bit-vectors. Furthermore, we present two variants of this data structure: one representing bits in dynamic bit-vectors explicitly and the other representing only the active bits by encoding their consecutive distances. In our experiments, we observed that our data structure improves space usage while having similar time performance for incremental updates when comparing with the previous strategy. The first variant of our data structure gives the best space improvement when constructing Time Transitive Closures for temporally dense temporal graphs, and the second variant uses less space for temporally sparse temporal graphs.
Giant Morgagni hernia and aorto-pulmonary collaterals in a Loeys–Dietz patient undergoing surgery for aortic root aneurysm and mitral valve prolapse
Authors: Lo Presti Federica , Palmiero Giuseppe , Limongelli Giuseppe , Della Corte Alessandro 
Published: July 2024

Abstract
The case of a Loeys–Dietz syndrome patient undergoing mitral valve repair and composite aortic root and valve replacement is here described: preoperative CT scan unravelled a previously misdiagnosed Morgagni hernia (anterior diaphragmatic), containing omentum only, compressing the right ventricle. Intraoperatively, an abnormal oxygenated blood backflow into the left ventricle was observed, postoperatively found to be caused by major aorto-pulmonary collateral arteries. This is the 1st case of Morgagni hernia and systemic-pulmonary shunt ever reported associated with Loeys–Dietz syndrome. These congenital features may be important in both phenotyping and surgical management.
Circle Homeomorphisms with Square Summable Diamond Shears
Authors: Šarić Dragomir , Wang Yilin , Wolfram Catherine 
Published: July 2024

Abstract
We introduce and study the space of homeomorphisms of the circle (up to Möbius transformations), which are in $\ell ^{2}$ with respect to modular coordinates called diamond shears along the edges of the Farey tessellation. Diamond shears are related combinatorially to shear coordinates and are also closely related to the $\log \Lambda $-lengths of decorated Teichmüller space introduced by Penner. We obtain sharp results comparing this new class to the Weil–Petersson class and Hölder classes of circle homeomorphisms. We also express the Weil–Petersson metric tensor and symplectic form in terms of infinitesimal shears and diamond shears.
Acute ST-elevation myocardial infarction (STEMI) in a young man with unknown multiple and mixed Valvular heart diseases: case report
Authors: Lahmouz Youssef , Nana Frederick , Faid Soumia , Britel Driss , Loudiyi Nadia , Faliouni Hicham , Mouine Najat , Lakhal Zouhair , Benyass Aatif 
Published: July 2024

Abstract
Although the incidence of systemic thromboembolism in valvular heart disease has been reported to be as high as 10% to 35%, embolization to the coronary arteries is uncommon. We present a case of a patient with acute myocardial infarction caused by coronary thromboemboli associated with combined valvular heart disease and atrial fibrillation. The thromboemboli were documented in the left descending artery. Coronary interventions including thromboaspiration and percutaneous coronary balloon angioplasty were attempted.
High prevalence of short telomeres in idiopathic porto-sinusoidal vascular disorder
Authors: Coukos Alexander , Saglietti Chiara , Sempoux Christine , Haubitz Monika , Greuter Thomas , Mittaz-Crettol Laureane , Maurer Fabienne , Mdawar-Bailly Elise , Moradpour Darius , Alberio Lorenzo , Good Jean-Marc , Baerlocher Gabriela M. , Fraga Montserrat 
Published: July 2024

Background:
Telomeres prevent damage to coding DNA as end-nucleotides are lost during mitosis. Mutations in telomere maintenance genes cause excessive telomere shortening, a condition known as short telomere syndrome (STS). One hepatic manifestation documented in STS is porto-sinusoidal vascular disorder (PSVD).

Methods:
As the etiology of many cases of PSVD remains unknown, this study explored the extent to which short telomeres are present in patients with idiopathic PSVD.

Results:
This monocentric cross-sectional study included patients with histologically defined idiopathic PSVD. Telomere length in 6 peripheral blood leukocyte subpopulations was assessed using fluorescent in situ hybridization and flow cytometry. Variants of telomere-related genes were identified using high-throughput exome sequencing. In total, 22 patients were included, of whom 16 (73%) had short (9/22) or very short (7/22) telomeres according to age-adjusted reference ranges. Fourteen patients (64%) had clinically significant portal hypertension. Shorter telomeres were more frequent in males (p = 0.005) and patients with concomitant interstitial lung disease (p < 0.001), chronic kidney disease (p < 0.001), and erythrocyte macrocytosis (p = 0.007). Portal hypertension (p = 0.021), low serum albumin level (p < 0.001), low platelet count (p = 0.007), and hyperbilirubinemia (p = 0.053) were also associated with shorter telomeres. Variants in known STS-related genes were identified in 4 patients with VSTel and 1 with STel.

Conclusions:
Short and very short telomeres were highly prevalent in patients with idiopathic PSVD, with 31% presenting with variants in telomere-related genes. Telomere biology may play an important role in vascular liver disease development. Clinicians should consider measuring telomeres in any patient presenting with PSVD.
Examining the Factors Affecting Psychological Well-Being in Certified Nurse Aides Working at Long-Term Care Institutions
Authors: CHEN Shiu-Ping , LIAO Hui-Yen , KUO Ju-Chuan , PAI Hsiang-Chu 
Published: July 2024

ABSTRACT

Background
The demand for certified nurse aides (CNAs) in long-term care institutions is gradually increasing. Factors such as well-being that positively influence the work of CNAs have been inadequately explored in the literature.

Purpose
This study was designed to examine the relationships among social support, self-efficacy, demographics, and psychological well-being in CNAs during the recent COVID-19 pandemic and to assess the moderating role of social support on self-efficacy and well-being in this population.

Methods
In this quantitative correlational study, CNAs from 24 legally registered long-term care institutions were recruited as participants. Data were collected using a demographic questionnaire, the General Self-Efficacy Scale, the Social Support Scale, and the Chinese Happiness Inventory. Partial least squares structural equation modeling was used to test the research hypotheses model. The Strengthening the Reporting of Observational Studies in Epidemiology checklist was followed in this cross-sectional study.

Results
A total of 148 CNAs were enrolled as participants. The mean age of the participants was 46.48 years. Social support and having children were identified as being significantly and positively correlated with well-being, and self-efficacy was identified as having no significant impact on well-being. Importantly, social support was found to moderate the relationship between self-efficacy and well-being. Overall, social support and having children were important predictors of well-being, with a combined explanatory power of 41.6% (Q
2 = .28, f
2 = 0.40).

Conclusions/Implications for Practice
Self-efficacy was found to be less predictive of well-being in the presence of higher levels of social support. Being a parent was also identified as an important factor affecting the well-being of CNAs under stress. Managers of long-term care institutions should intervene to improve the CNA's social support. Also, CNAs who do not have children should pay more attention to their well-being.
Development and Validation of the Dementia Caregiver Burden Scale: A Tool for Community-Dwelling Dementia Caregiver
Authors: CHO Mijung , KIM Oksoo 
Published: July 2024

ABSTRACT

Background
The number of patients with dementia increases rapidly in aging populations. Dementia is an irreversible disease that causes a patient to be dependent on others' care and also causes family caregivers to experience difficulties in multiple domains.

Purpose
In this study, a dementia caregiver's burden scale that addresses family caregivers' characteristics and caring environments was developed and validated.

Methods
In-depth interviews with nine caregivers were conducted to identify the attributes of perceived burden and establish preliminary questions. Content validity was confirmed by seven experts using the item content validity index and scale content validity index/average. Construct validity, criterion-related validity, and reliability were verified using data from 205 primary caregivers of patients with dementia.

Results
Exploratory factor analysis revealed that five factors, including physical health deterioration, responsibility and role of caregiver, emotional distress, medical expense concerns, and family conflict, and 24 items explained 68.6% of the total variance. The calculated Cronbach's α for the overall scale was .96.

Conclusions
The scale developed in this study may be used to measure the burden perceived by family caregivers of patients with dementia in the physical, emotional, social, financial, and situational domains. Also, the scale may be used to guide the development of tailored interventions that take into consideration different family caregiver and caring situation-related characteristics.
DNA methylation urine test in the diagnosis of upper tract urothelial carcinoma: a systematic review and meta-analysis
Authors: Ye Jianjun , Wang Xiaoli , Liao Xinyang , Chen Ye , Chen Zeyu , Wang Qihao , Ai Jianzhong , Wei Qiang , Bao Yige 
Published: July 2024

Objective:
The DNA methylation urine test, a noninvasive early detection method for upper tract urothelial carcinoma (UTUC), is currently in full swing. This study aimed to systematically assess its diagnostic performance on UTUC.

Materials and methods:
PubMed, Scopus, Embase, and Cochrane were our main databases when searching articles published from January 2000 to December 2023. Sensitivity and specificity were study primary endpoints. I
2 was used to evaluated heterogeneity, meanwhile subgroup and meta-regression analyses were adopted to investigated the source of heterogeneity. Sensitivity analysis was performed to evaluate the result robustness, while Deeks’ funnel plot asymmetry test was for the publication bias.

Results:
Nine studies with 1326 patients were included. The pooled sensitivity was 0.89 (95% CI: 0.83–0.93) and specificity were 0.91 (95% CI: 0.83–0.96). The area under the receiver operating characteristic curve was 0.96 (95% CI: 0.93–0.97). Substantial heterogeneity was found during the data synthesis, whereas the pooled results remained robust in the sensitivity analysis. None of the potential covariates—urine sample collection method, population, country, methylation test method, or tumor grade—could account for the heterogeneity.

Conclusion:
DNA methylation urine test is a promising method with high efficiency for UTUC early detection. Nevertheless, owing to the significant heterogeneity, more well-organized studies are warranted to further explore its diagnostic efficiency and application context.
Rare occurrence of sagittal sinus thrombosis and haemorrhagic infarction with dengue fever: jumping from traditional symptoms to lethal neurological consequences
Authors: Abbasher Hussien Mohamed Ahmed Khabab , Abbasher AlHussein , Siddig Amira , Abbasher Mohammed , Abbasher Abubaker Alsedig , Abdelhaleem Omar Ahmed Ali , Shihab Hamednalla Abdelgader Zinab , Hassan Salih Elhaj Esraa , Ahsan Areeba , Mustafa Ahmed Ghassan E. , Hussien Abbasher 
Published: July 2024

Introduction and importance:
Dengue virus (DENV) is an RNA virus transmitted by Aides mosquito causing dengue fever. There is growing recognition of neurological symptoms associated with DENV infection, some of which might be lethal if left untreated. Case reports describing sagittal sinus thrombosis, as a serious neurologic consequence of dengue infection, are rare. It is still unknown how often sagittal sinus thrombosis occurs and what variables increase the risk in dengue patients.

Case presentation:
Herein the authors presented an elderly Sudanese patient diagnosed with dengue fever. He was admitted, then 2 days after admission, the condition was complicated by atrial fibrillation, sagittal sinus thrombosis complicated by massive left temporal lobe infarction with haemorrhagic transformation and recurrent episodes of status epilepticus. After receiving the necessary care, his condition remained the same and no progress or deterioration was seen.

Clinical discussion:
Sagittal sinus thrombosis can happen due to several underlying causes. DENV can very rarely lead to such condition. The authors’ patient developed this condition, which was later complicated by ischaemic stroke with haemorrhagic transformation and status epilepticus. In addition to a familial history of DVT and a history of myocardial infarction, our patient also acquired cardiac mural thrombus and DVT throughout his illness, which increased the suspicion of a protein C, protein S, or antithrombin 3 deficiency.

Conclusion:
Sagittal sinus thrombosis with haemorrhagic infarction associated with thrombocytopenia is a very rare kind of stroke that occurs in dengue. Dengue as a pathogenic mechanism of ischaemic stroke requires validation with further data.
Ostomy Care Nurses’ Knowledge and Practice Related to Prevention and Management of Parastomal Hernias in Adults
Authors: Smith Clare , Cook Neal 
Published: July 2024

PURPOSE:
The purpose of this study was to describe the knowledge and practices of ostomy care nurses related to the United Kingdom’s Association of Stoma Care Nurses (ASCN) 2016 guidelines for prevention and management of parastomal hernia (PSH) in adults.

DESIGN:
Cross-sectional descriptive study.

SUBJECTS AND SETTING:
The target population was approximately 300 stoma care nurses; 120 useable responses to the survey were received, reflecting a response rate of approximately 40%.

METHODS:
A 31-item questionnaire was developed for the purposes of this study, consisting of multiple choice and short answer questions grouped into 2 sections; demographics, and knowledge and practices. The questionnaire was distributed to members of the ASCN who work with adults via an online survey platform with the aim of reaching as many respondents as possible. The Chi-square test was used to determine relationships between the nominal demographic data and the nominal knowledge and practices data.

RESULTS:
Almost two-thirds of respondents (65%, n = 78) rated their knowledge relating to prevention and management of PSH as good or excellent. Nevertheless, 79.8% (n = 95) indicated they needed additional education to improve their knowledge and practice related to prevention of PSH. Those who rated their knowledge as excellent or good were significantly more likely to be aware of the guidelines compared to those who ranked their knowledge as average or poor.

CONCLUSIONS:
Study findings suggest variability in knowledge among UK stoma care nurses, along with a desire for additional education in this area of care.
Examination of the Odor-Eliminating Effect of a Deodorizing Spray on the Volatile Odorants of Malignant Wounds
Authors: Matsubara Yasumi , Kiyonmiya Mie , Nagayasu Takahiro 
Published: July 2024

PURPOSE:
This study aimed to compare the odor components before and after spraying a deodorizing spray (DS) on volatile odorants in malignant wounds (MWs) in women with breast cancer; a secondary aim was to evaluate the deodorizing effect of the DS.

DESIGN:
This is an observational study.

SUBJECTS AND SETTING:
We investigated 3 patients who had MWs resulting from breast cancer. Participants were recruited from outpatient clinics in the Breast Surgery Department, University Hospital, Kanagawa, Japan.

METHODS:
The target material was exudate-containing dressings collected from MWs. After collection, the odor components (air) were collected into a sampling bag by using a handheld pump. Then, after 5 sprays of a DS, air was collected in the same manner. All odor components were analyzed objectively by gas chromatography-mass spectrometry-olfactometry (GC/MS-O). The concentration in parts per million (ppm) of the main odor components in the air before and after spraying DS was compared, and the residual concentration rate (%) was calculated. Sniffing tests before and after spraying were also conducted to determine the subjective deodorizing effect of DS.

RESULTS:
Of the possible hundreds of volatile odorants, 3 to 11 main components of volatile odorants were detected per subject. After DS spraying, the odorants dimethyl disulfide, dimethyl trisulfide, and benzyl alcohol were reduced according to GC/MS-O. The residual concentration of the following main odor components was also reduced: benzyl alcohol (30%), octanal (56%), p-dichlorobenzene (56%), isovaleric acid (56%), propylene glycol (63%), and nonanal (66%).

CONCLUSIONS:
DS was effective against some volatile odorants in MWs, but no clear deodorizing effect was observed. Since there are individual differences in the type and number of odorants in MWs, the use of DS needs to be examined and verified in a larger number of cases.
Dynamin 1-mediated endocytic recycling of glycosylated N-cadherin sustains the plastic mesenchymal state to promote ovarian cancer metastasis
Authors: Cai Yuee , To Sally K. Y. , Guan Zhangyan , Tong Yin , Zhang Jiangwen , Peng Ling , Ip Philip P. C. , Wong Alice S. T. 
Published: July 2024

ABSTRACTEpithelial-to-mesenchymal transition (EMT) is a key process that confers metastatic plasticity to ovarian cancer cells, enabling them to disseminate aggressively throughout the peritoneal cavity and contributing to poor clinical outcomes for patients. However, a pharmacologically exploitable driver of EMT in ovarian cancer has yet to be identified. To address this, we utilized a master regulators algorithm to prioritize EMT regulators from a dataset of over 8,000 patient samples, including multidimensional omics data from more than 20 cancer types in TCGA. Further analysis identified dynamin-1 (DNM1), an endocytic regulator, as a novel master regulator of EMT in ovarian cancer. Clinically, DNM1 overexpression was found to be associated with the mesenchymal subtype and advanced/metastatic stages of ovarian carcinomas. Molecular assays revealed that DNM1 upregulates N-cadherin, a hallmark mesenchymal marker, by promoting its endocytosis and recycling, thereby inducing cell polarization and motility. In addition, integration of ATAC-seq and RNA-seq analyses uncovered the repression of beta-1,3-galactosyltransferase (B3GALT1), a glycosyltransferase, in metastatic cells. B3GALT1-mediated glycosylation hindered the recycling of N-cadherin. Functional studies demonstrated that depletion of DNM1 or pharmacological inhibition of endocytic recycling significantly impaired cell polarity, migration, and also cancer stemness. Importantly,in vivoexperiments showed that the loss of DNM1 significantly suppressed peritoneal metastatic colonization. Interestingly, metastatic cells with elevated DNM1-mediated endocytosis showed increased susceptibility to nanoparticle delivery. Collectively, these results establish the DNM1-N-cadherin axis as an important regulator of EMT-associated ovarian cancer metastasis and suggest its potential as a biomarker for targeted nanodrug therapy.
Artifact-Minimized High-Ratio Image Compression with Preserved Analysis Fidelity
Authors: Duan Bin , Walker Logan A , Xie Bin , Lee Wei Jie , Lin Alexander , Yan Yan , Cai Dawen 
Published: July 2024

ABSTRACTRecent advances in microscopy have pushed imaging data generation to an unprecedented scale. While scientists benefit from higher spatiotemporal resolutions and larger imaging volumes, the increasing data size presents significant storage, visualization, sharing, and analysis challenges. Lossless compression typically reduces the data size by <4 fold, whereas lossy compression trades smaller data size for the loss of a precise reconstruction of the original data. Here, we develop a novel quantization method and an artifact metric for automated compression parameter optimization that preserves information fidelity. We show that, when combined with the AV1 video codec, we achieve tens to ten thousand folds of data compression while introducing negligible visual defects or quantification errors in single-molecule localization and segmentation analyses. We developed an HDF5 filter with FFMPEG library support for convenient community adaptation. For instance, HDF5-enabled ImageJ plugins can now be seamlessly extended to support AV1 compression and visualization to handle terabyte-scale images.
The role ofpolycystic kidney disease-likehomologs in planarian nervous system regeneration and function
Authors: Ross Kelly G. , Zepeda Sarai Alvarez , Auwal Mohammad A. , Garces Audrey K. , Roman Sydney , Zayas Ricardo M. 
Published: July 2024

AbstractPlanarians are an excellent model for investigating molecular mechanisms necessary for regenerating a functional nervous system. Numerous studies have led to the generation of extensive genomic resources, especially whole-animal single-cell RNA-seq resources. These have facilitatedin silicopredictions of neuronal subtypes, many of which have been anatomically mapped by in situ hybridization. However, our knowledge of the function of dozens of neuronal subtypes remains poorly understood. Previous investigations identified thatpolycystic kidney disease (pkd)-likegenes in planarians are strongly expressed in sensory neurons and have roles in mechanosensation. Here, we examine the expression and function of all thepkdgenes found in theSchmidtea mediterraneagenome and map their expression in the asexual and hermaphroditic strains. Using custom behavioral assays, we test the function ofpkdgenes in response to mechanical stimulation and in food detection. Our work provides insight into the physiological function of sensory neuron populations and protocols for creating inexpensive automated setups for acquiring and analyzing mechanosensory stimulation in planarians.