bluuebunny/crossref_metadata_2025_split huggingface dataset:
c‐Met inhibition in a HOXA9/Meis1 model of CN‐AML
Authors: Mulgrew Nuala M. , Kettyle Laura M.J. , Ramsey Joanne M. , Cull Susan , Smyth Laura J. , Mervyn Danielle M. , Bijl Janet J. , Thompson Alexander 
Published: December 2013

ABSTRACTBackground: Hematopoiesis is a paradigm for developmental processes, hierarchically organized, with stem cells at its origin. Hematopoietic stem cells (HSCs) replenish progenitor and precursor cells of multiple lineages, which normally differentiate into short‐lived mature circulating cells. Hematopoiesis has provided insight into the molecular basis of tissue homeostasis and malignancy. Malignant hematopoiesis, in particular acute myeloid leukemia (AML), results from impaired development or differentiation of HSCs and progenitors. Co‐overexpression of HOX and TALE genes, particularly the HOXA cluster and MEIS1, is associated with AML. Clinically relevant models of AML are required to advance drug development for an aging patient cohort. Results: Molecular analysis identified altered gene, microRNA, and protein expression in HOXA9/Meis1 leukemic bone marrow compared to normal controls. A candidate drug screen identified the c‐Met inhibitor SU11274 for further analysis. Altered cell cycle status, apoptosis, differentiation, and impaired colony formation were shown for SU11274 in AML cell lines and primary leukemic bone marrow. Conclusions: The clonal HOXA9/Meis1 AML model is amenable to drug screening analysis. The data presented indicate that human AML cells respond in a similar manner to the HOXA9/Meis1 cells, indicating pre‐clinical relevance of the mouse model. Developmental Dynamics 243:172–181, 2014. © 2013 Wiley Periodicals, Inc.
Spin Frustration in Triangular Cu3II Complexes with 6‐Methyl‐2‐pyridyloxime as Ligand – Synthesis, Structural, and Magnetic Characterization
Authors: Escuer Albert , Vlahopoulou Gina , Lloret Francesc , Mautner Franz A. 
Published: December 2013

AbstractIn the present work, new examples of μ3‐OH/oximato Cu3 triangles have been obtained by treatment of different copper salts with 6‐methyl‐2‐pyridylaldoxime [6‐MepyC(H)NOH, 6‐mepaoH]. Depending on the anion, the compounds [Cu3(OH)(6‐mepao)3(O2CPh)2] (1), [Cu6(OH)2(6‐mepao)6(NO3)3](NO3)·H2O (2·H2O) and [Cu6(OH)2(6‐mepao)6(ClO4)3](ClO4) (3) formed and were characterized. Complex 1 is an isolated triangle, whereas 2 and 3 are hexanuclear compounds with two triangular subunits linked by anionic bridges. Susceptibility measurements show very strong antiferromagnetic interactions and the presence of antisymmetric exchange at low temperature. The magnetic properties of these frustrated triangles have been analyzed in terms of susceptibility, magnetization and electron paramagnetic resonance (EPR) experiments.
Structural Evidence for Lewis Acid Triggered Nitrosyl Bending in Rhenium(–I) Chloro Catalysts for Alkene Hydrogenation Reactions
Authors: Jiang Yanfeng , Huang Wenjing , Schmalle Helmut W. , Blacque Olivier , Fox Thomas , Berke Heinz 
Published: December 2013

AbstractThe “catalytic nitrosyl effect” operating in reversible nitrosyl bending governs the performance of NO‐functionalized chlororhenium derivatives as catalysts in 1‐hexene hydrogenation reactions. Structural support for a Lewis acid (LA) induced bending at the NNO atom was provided by terminal attachment of a Lewis acid to one of the nitrosyl ligands in the [ReCl(PR3)2(NO)2] complexes (2: R = iPr a, R = Cy b) to give the products [ReCl(PR3)2(NO)(NO‐LA)][Z] {3: LA = B(C6F5)3; 4: LA = Et+; Z = [B(C6F5)4]–; 5a: LA = SiEt3+, Z = [HB(C6F5)3]–; R = iPr a, Cy b}. X‐ray diffraction studies revealed a moderately bent nitrosyl ligand in the nonderivatized complex 2a [159.3(5)°] and fully bent NO‐LA groups in 3a [131.4(3)°] and 4b [132.7(3)°]. The catalytic activities of the chloro dinitrosyl complexes in the hydrogenation of prototypical 1‐hexene were investigated. The NO‐LA bent complexes 3b and 4b furnished excellent TONs of up to 1.0 × 104 and high TOFs of up to 5.4 × 104 h–1 when the Lewis acids were present as co‐catalysts.
Lithium Salts of 2,4,6‐Triaryl‐λ4‐phosphinine Anions – A Comparison Study
Authors: Bruce Marlene , Meissner Gisa , Weber Manuela , Wiecko Jelena , Müller Christian 
Published: December 2013

AbstractThe λ3‐phosphinine derivatives 2,6‐diphenyl‐4‐(p‐tolyl)phosphinine and 2‐(2′‐pyridyl)‐4,6‐diphenylphosphinine were quantitatively converted into the corresponding λ4‐phosphinine anions by reaction with phenyllithium. Systematic hydrolysis experiments with H2O and MeOH show that a subtle interplay between the pKa values of the generated 1,2‐dihydrophosphinine derivatives and the pKb value of the formed bases, LiOH and LiOCH3, respectively, leads either to the kinetic or thermodynamic product. The coordination chemistry of the λ4‐phosphinine anions towards RhI was further investigated, and the anions based on 2,6‐diphenyl‐4‐(p‐tolyl)‐phosphinine and 2‐(2′‐pyridyl)‐4,6‐diphenylphosphinine demonstrate different coordination modes. Whereas the former coordinates in an η5 fashion towards the RhI atom, the latter acts as a bidentate chelating ligand with an η1 coordination to the metal center through the phosphorus lone pair.
Tuning the Photophysical Properties of 2‐Quinolinone‐Based Donor–Acceptor Molecules through N‐ versus O‐Alkylation: Insights from Experimental and Theoretical Investigations
Authors: Paramaguru Ganesan , Solomon Rajadurai Vijay , Jagadeeswari Sivanadanam , Venuvanalingam Ponnambalam , Renganathan Rajalingam 
Published: December 2013

AbstractA series of 2‐quinolinone‐based molecular systems with three different acceptor groups and N/O‐alkylated quinolinone compounds have been synthesised in an attempt to understand their optical properties. All the compounds were characterised by 1H NMR, 13C NMR and mass analysis. Absorption measurements revealed that charge‐transfer transition was observed by introducing electron‐withdrawing acceptor groups. Alkylation of 2‐quinolinone at the O‐position thwarts the charge‐transfer transitions, whereas N‐alkylation retains the charge‐transfer property. The presence of resonance zwitterionic forms in the unalkylated and N‐alkylated quinolinone compounds play an important role in charge‐transfer transition. The effects of solvents on the absorption and emission properties of these compounds were probed through Lippert Mataga and ET(30) correlation. The Stokes shifts of O‐alkylated compounds were larger than those of the unalkylated and N‐alkylated quinolinone compounds. The observed higher quantum yield and Stokes shift for these compounds will make them ideal fluorescent probes. Incorporation of acceptor groups and alkylation in the quinolinone moiety alters their energy levels. Good thermal stability was observed for both unalkylated and alkylated quinolinone compounds. The trends observed in the photophysical and electrochemical properties were supported by theoretical studies. The observed tunable optical properties, which were achieved through simple N‐ vs. O‐alkylation, results in large Stokes shifts and thermal stability, which means that the 2‐quinolinone‐based molecular systems are expected to emerge as potential candidates for photovoltaic and biological applications.
Phenyliodine(III) Diacetate (PIDA) Mediated Synthesis of Aromatic Azo Compounds through Oxidative Dehydrogenative Coupling of Anilines: Scope and Mechanism
Authors: Monir Kamarul , Ghosh Monoranjan , Mishra Subhajit , Majee Adinath , Hajra Alakananda 
Published: December 2013

AbstractAn efficient and environmentally benign method has been developed for the synthesis of symmetrical and unsymmetrical aromatic azo compounds through phenyliodine(III) diacetate (PIDA) mediated oxidative dehydrogenative coupling of anilines in high yields. The scope of the reaction is broad for both homo‐ and cross‐dimerization. A plausible reaction mechanism has been proposed based on a structurally characterized key intermediate, suggesting that ethanol is involved in the reaction pathway. Fast reaction, metal‐free conditions, and functional‐group tolerance are advantages of this method.
Screen‐Display‐Induced Photoresponse Mapping for Large‐Area Photovoltaics
Authors: Gupta Ritu , Kiruthika S. , Rao K. D. M. , Jørgensen M. , Krebs F. C. , Kulkarni G. U. 
Published: December 2013

AbstractAs solar cell modules are becoming larger, it is important to pay attention to defects originating from the fabrication process and degradation during operation in the ambient. In this article, a simple method of using computer screen display as a light source to map the photoresponse of the solar cells, is reported. The method requires only a conventional computer loaded with a software code that enables a light spot of defined size to raster scan across the cell area as the photogenerated voltage is read out by a voltmeter using a USB connection. Screen‐display‐induced photoresponse (SDIP) mapping is an enabling technique to reveal the defective regions in the active layer as well as at the electrode interface, which, in many instances, cannot be deciphered simply by visual examination. Spectral response mapping by using light spots of different colors is also possible.
CHALLENGES IN MECHANISTIC AND EMPIRICAL MODELLING OF STORMWATER: REVIEW AND PERSPECTIVES
Authors: Al‐Amin Shams , Abdul‐Aziz Omar I. 
Published: December 2013

ABSTRACTMuch research has been conducted to quantify stormwater runoff and quality using both mechanistic (i.e. process‐based) and empirical (i.e. data‐driven) techniques. Mechanistic models generally include the mathematical representation of relevant physico‐chemical processes to generate storm runoff quantity and quality. Empirical approaches analyse available data for potential response and predictor variables to trace the interactions of major processes and develop data‐driven explanatory and/or predictive relationships. This paper reviews major, mostly unresolved, challenges with both mechanistic and empirical modelling of stormwater, sheds light on the scientific gaps with conventional practices, and offers important perspectives by taking the highly urbanized Miami River Basin of Florida as an analytical example. Appreciating the varying levels of process complexity in different urban river basins, we discuss the relative applicability of mechanistic and empirical methods for robust predictions of stormwater quantity and quality. Copyright © 2013 John Wiley & Sons, Ltd.
WATER QUALITY TRADING PROGRAMS TOWARDS SOLVING ENVIRONMENTAL POLLUTION PROBLEMS
Authors: Corrales Juliana , Melodie Naja G. , Rivero Rosanna. G. , Miralles‐Wilhelm Fernando , Bhat Mahadev G. 
Published: December 2013

ABSTRACTIncreased regulatory attention in controlling pollutants has encouraged the development of water quality trading programs over the past several decades. These trading programs could provide the mechanisms to cost‐effectively achieve water quality objectives. Encouragement of innovative methodologies for emission prevention and control, and the contributions from non‐regulated pollution sources, are also important factors in the development of successful water quality trading programs. The objectives of this paper are to: assess the advantages of a trading program to reach water quality goals while providing additional benefits to the whole watershed; describe the challenges confronted during the design to implementation phases; and outline the essential elements of a successful program. A meta‐analysis was also conducted using several water quality trading programs to assess main market‐based elements driving the success of trading programs between point and agricultural nonpoint sources. Uncertainty, policy drivers and social embeddedness––the degree to which stakeholders are integrated into program development––seem to be the most influential determinant of program success. Copyright © 2013 John Wiley & Sons, Ltd.
Evaluation of the toxicity of food additive silica nanoparticles on gastrointestinal cells
Authors: Yang Yi‐Xin , Song Zheng‐Mei , Cheng Bin , Xiang Kun , Chen Xin‐Xin , Liu Jia‐Hui , Cao Aoneng , Wang Yanli , Liu Yuanfang , Wang Haifang 
Published: December 2013

ABSTRACTSilica nanoparticles (NPs) have been widely used in food products as an additive; however, their toxicity and safety to the human body and the environment still remain unclear. As a food additive, silica NPs firstly enter the human gastrointestinal tract along with food, thus their gastrointestinal toxicity deserves thorough study. Herein, we evaluated the toxicity of food additive silica NPs to cells originating from the gastrointestinal tract. Four silica NP samples were introduced to human gastric epithelial cell GES‐1 and colorectal adenocarcinoma cell Caco‐2 to investigate the effect of silica sample, exposure dose and exposure period on the morphology, viability and membrane integrity of cells. The cell uptake, cellular reactive oxygen species (ROS) level, cell cycle and apoptosis were determined to reveal the toxicity mechanism. The results indicate that all four silica NPs are safe for both GES‐1 and Caco‐2 cells after 24‐h exposure at a concentration lower than 100 µg ml–1. At a higher concentration and longer exposure period, silica NPs do not induce the apoptosis/necrosis of cells, but arrest cell cycle and inhibit the cell growth. Notably, silica NPs do not pass through the Caco‐2 cell monolayer after 4‐h contact, indicating the low potential of silica NPs to cross the gastrointestinal tract in vivo. Our findings indicate that silica NPs could be used as a safe food additive, but more investigations, such as long‐term in vivo exposure, are necessary in future studies. Copyright © 2013 John Wiley & Sons, Ltd.
Perioperative only versus extended antimicrobial usage in tympanomastoid surgery: A randomized trial
Authors: Bidkar Vijay G. , Jalisatigi Roshan R. , Naik Ashok S. , Shanbag Raghunath D. , Siddappa Rashmi , Sharma Poorvi V. , Hegde Harihar V. 
Published: December 2013

Objectives/HypothesisAntimicrobial prophylaxis is still a matter of debate in ear surgeries. Previous studies have focused on prophylaxis in middle ear surgery alone without inclusion of mastoidectomy. We therefore investigated efficacy of two regimes of antimicrobial prophylaxis in tympanoplasty with cortical mastoidectomy done for mild middle ear disease in chronic otitis media.Study DesignProspective, randomized, controlled, double‐blind study.MethodsPatients undergoing tympanoplasty with cortical mastoidectomy were included and randomized into two study groups. The group I patients received parenteral perioperative antimicrobials; only group II patients received additional extended oral antimicrobials for 8 days more postoperatively. Primary outcomes evaluated were postaural wound infection and graft success, assessed weekly until 1 month. Adverse events and length of hospital stay were evaluated as secondary outcome.ResultsSeventy‐eight patients were randomized into group I (n = 39) and group II (n = 39). The two groups showed no difference in wound infection rate. The graft success rate in both the group was comparable (94.87% in group I and 97.44% in group II, respectively; P = 1.00). The length of hospital stay was significantly longer (P = 0.00001) in group II (3.05 [0.72], mean [SD]) as compared to group I (2.36 [0.49]). During the first postoperative week, a significantly higher incidence of gastrointestinal disturbances were observed in group II (19 [48.72%] as compared to 1 [2.56%] in group I, P = 0.00001).ConclusionThe present study shows that there is no need of extended antimicrobial prophylaxis for tympanoplasty with cortical mastoidectomy done for mild middle ear disease. An indiscriminate use of antimicrobials may lead to increase incidence of adverse events and prolonged hospital stay.Level of Evidence1b. Laryngoscope, 124:1459–1463, 2014
Glucagon‐like peptide 1‐based therapies and risk of pancreatitis: a self‐controlled case series analysis
Authors: Li Xiaochun , Zhang Zuoyi , Duke Jon 
Published: December 2013

ABSTRACTPurposePrevious studies have suggested a link between glucagon‐like peptide 1 (GLP‐1)‐based therapies and acute pancreatitis, while other studies have found no association. Because differences in diabetes severity may confound this relationship, a self‐controlled case series (SCCS) analysis has been suggested as a means to control for individual‐level confounding.MethodsWe evaluated the relationship between GLP‐1‐based therapies and pancreatitis by SCCS method using a large observational database. We calculated the incidence density ratio of pancreatitis for exposure versus non‐exposure to each drug. To examine the robustness of our findings, we performed sensitivity analyses by varying risk windows, using two pancreatitis definitions and including incident pancreatitis or all occurrences.ResultsFrom dispensing data on 1.2 million patients, we found 7992 sitagliptin‐exposed patients and 3552 exenatide‐exposed patients between 2004 and 2009. Using an ICD9/CPT‐based case definition of pancreatitis, we identified 207 sitagliptin and 82 exenatide cases. Augmenting this definition with laboratory criteria increased our cohort to 245 sitagliptin and 96 exenatide cases. For sitagliptin and exenatide cases, respectively, the mean duration of observation was 5.2 and 5.5 years, and the mean duration of drug exposure was 0.7 and 0.5 years. For all analyses (including different pancreatitis definitions, risk periods, and incident or recurrent events), the incidence density ratios for development of pancreatitis during exposure versus non‐exposure ranged from 0.68 to 1.46, with all having 95% confidence intervals containing 1.ConclusionsWe found no association between the use of GLP‐1‐based therapies and pancreatitis using SCCS analysis in a large observational database. Copyright © 2013 John Wiley & Sons, Ltd.
Inkjet printed PEDOT:PSS/MWCNT nano‐composites with aligned carbon nanotubes and enhanced conductivity
Authors: Alshammari A. S. , Shkunov M. , Silva S. Ravi P. 
Published: December 2013

AbstractConductive patterns of poly(3,4‐ethylenedioxythiophene) poly(styrenesulfonate) (PEDOT:PSS)/multi‐walled carbon nanotube (MWCNT) composites were deposited on glass substrates using a drop on demand (DOD) inkjet printer, with the concentration of CNT varied from 0.01 wt% to 0.05 wt%. We show that by increasing the concentration of the nanotubes in the ink, percolated networks of well distributed carbon nanotubes in the printed samples can be achieved. Moreover, the orientation of the nanotubes in the printed sample can be controlled using a novel simple approach. The impact of the nanotube alignment on the conduction properties of inkjet printed nano‐hybrid materials is studied and shown in this Letter. Samples with aligned nanotubes show a 53% enhanced conductivity in comparison with the randomly oriented nanotubes. The results show that the electrical performance of the nano‐composite can be improved further by controlling the dispersion and orientation of the nano‐filler in the printed samples.magnified imageCarbon nanotubes orientation control in the printed PEDOT:PSS/MWCNT nano‐composite samples.(© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Design of an adaptive terminal sliding‐function controller for nonlinear multivariable systems
Authors: Huang Yun‐Cheng , Li Tzuu‐Hseng S. 
Published: December 2013

SummaryThis paper presents an adaptive terminal sliding‐function controller approach for controlling a class of nonlinear multivariable systems with uncertainty. An appropriate terminal sliding function (TSF) is designed and then applied to the control law. Based on the Lyapunov stability theory, the adaptive terminal sliding‐function controller for nonlinear multivariable systems guarantees that the TSF is asymptotically convergent. Different from classical terminal sliding mode control, which uses a discontinuous switching control law, the TSF control uses a continuous TSF and thus avoids the chattering problem. The simulation results demonstrate that the proposed method achieves satisfactory stability. Copyright © 2013 John Wiley & Sons, Ltd.
Performance of SEM scintillation detector evaluated by modulation transfer function and detective quantum efficiency function
Authors: Bok Jan , Schauer Petr 
Published: December 2013

SummaryIn the paper, the SEM detector is evaluated by the modulation transfer function (MTF) which expresses the detector's influence on the SEM image contrast. This is a novel approach, since the MTF was used previously to describe only the area imaging detectors, or whole imaging systems. The measurement technique and calculation of the MTF for the SEM detector are presented. In addition, the measurement and calculation of the detective quantum efficiency (DQE) as a function of the spatial frequency for the SEM detector are described. In this technique, the time modulated e‐beam is used in order to create well‐defined input signal for the detector. The MTF and DQE measurements are demonstrated on the Everhart–Thornley scintillation detector. This detector was alternated using the YAG:Ce, YAP:Ce, and CRY18 single‐crystal scintillators. The presented MTF and DQE characteristics show good imaging properties of the detectors with the YAP:Ce or CRY18 scintillator, especially for a specific type of the e‐beam scan. The results demonstrate the great benefit of the description of SEM detectors using the MTF and DQE. In addition, point‐by‐point and continual‐sweep e‐beam scans in SEM were discussed and their influence on the image quality was revealed using the MTF. SCANNING 36:384–393, 2014. © 2013 Wiley Periodicals, Inc.
Module Assembly for Designing Multivalent Mid‐Sized Inhibitors of Protein‐Protein Interactions
Authors: Ohkanda Junko 
Published: December 2013

AbstractDeveloping clinically relevant synthetic agents that are capable of disrupting protein‐protein interactions (PPIs) is now a major goal of scientific research. In an effort to explore new methodologies that are applicable to the design of synthetic PPI inhibitors, we examined a strategy based on the assembly of small module compounds to create multivalent mid‐sized agents. This personal account describes three particular approaches based on module assembly: metal‐chelating‐based ligand assembly, covalent chemical ligation templated by a targeted protein, and bivalent inhibitor design for simultaneous targeting of the active pocket and protein surface. These strategies were shown to be useful for synthesizing minimally sized synthetic agents for targeting PPIs and may enable development of agents that are applicable to inhibition of intracellular PPIs.