bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association between Hearing Loss and Periodontitis: Insights from the NHANES Database
Authors: Zou Zhijiang , Chen Kehan , Mei Ruoyu , Lou Yuhang , Liu Zhongzheng , Xu Bing , Song Jukun , He Wei 
Published: July 2024

Abstract

Background
Despite the prevalence of periodontitis and hearing impairment, research exploring their association is limited. This study aims to examine the potential relationship between periodontitis and hearing loss, using data from The National Health and Nutrition Examination Survey (NHANES) 2009–2012.
Methods
Data from the National Health and Nutrition Examination Survey (NHANES) for the years 2009–2012 were analyzed, focusing on participants who underwent both periodontal examinations and audiometric testing. The study included 1,642 participants after excluding those with incomplete data. Periodontitis was dichotomized as a binary variable of presence or absence. HL was both a categorical variable after grouping and an ungrouped continuous variable. Data were analyzed by multifactor logistic regression and subgroup analysis using EmpowerStats 3.0 software, and restricted cubic curves were plotted using R 4.3.2.
Results
The results showed that the prevalence of periodontitis was 60.97% and the hearing impaired population comprised 12.48% of the study population. There was a significant correlation between the severity of hearing loss and the presence of moderate to severe periodontitis. Participants with hearing loss greater than 40 dB showed a markedly higher likelihood of having periodontitis compared to those with normal hearing, even after adjusting for potential confounders such as age, smoking, diabetes, and socioeconomic status.
Conclusions
The findings suggest a notable association between hearing impairment and the risk of periodontitis. The study highlights the importance of considering oral health in patients with hearing loss and suggests further investigation into the shared inflammatory pathways that may contribute to both conditions.
Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease
Authors: Debette Stephanie , Caro Ilana , Western Daniel , Namba Shinichi , Sun Na , Kawaguchi Shuji , He Yunye , Fujita Masashi , Roshchupkin Gennady , D'Aoust Tim , Duperron Marie-Gabrielle , Sargurupremraj Murali , Tsuchida Ami , Koido Masaru , Ahmadi Marziehsadat , Yang Chengran , Timsina Jigyasha , Ibanez Laura , Matsuda Koichi , Suzuki Yutaka , Oda Yoshiya , Kanai Akinori , Jandaghi Pouria , Munter Hans Markus , Auld Dan , Astafeva Iana , Puerta Raquel , Rotter Jerome , Psaty Bruce , Bis Joshua , Longstreth Will , Couffinhal Thierry , Garcia-Gonzalez Pablo , Pytel Vanesa , Marquié Marta , Cano Amanda , Boada Mercè , Joliot Marc , Lathrop Mark , Grand Quentin Le , Launer Lenore , Wardlaw Joanna , Heiman Myriam , Ruiz Agustin , Matthews Paul , Seshadri Sudha , Fornage Myriam , Adams Hieab , Mishra Aniket , Trégouët David-Alexandre , Okada Yukinori , Kellis Manolis , De Jager Philip , Tzourio Christophe , Kamatani Yoichiro , Matsuda Fumihiko , Cruchaga Carlos 
Published: July 2024

Abstract

Cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia with no specific mechanism-based treatment. We used Mendelian randomization to combine a unique cerebrospinal fluid (CSF) and plasma pQTL resource with the latest European-ancestry GWAS of MRI-markers of cSVD (white matter hyperintensities, perivascular spaces). We describe a new biological fingerprint of 49 protein-cSVD associations, predominantly in the CSF. We implemented a multipronged follow-up, across fluids, platforms, and ancestries (Europeans and East-Asian), including testing associations of direct plasma protein measurements with MRI-cSVD. We highlight 16 proteins robustly associated in both CSF and plasma, with 24/4 proteins identified in CSF/plasma only. cSVD-proteins were enriched in extracellular matrix and immune response pathways, and in genes enriched in microglia and specific microglial states (integration with single-nucleus RNA sequencing). Immune-related proteins were associated with MRI-cSVD already at age twenty. Half of cSVD-proteins were associated with stroke, dementia, or both, and seven cSVD-proteins are targets for known drugs (used for other indications in directions compatible with beneficial therapeutic effects. This first cSVD proteogenomic signature opens new avenues for biomarker and therapeutic developments.
WITHDRAWN: Epitope-based Vaccine Design for California Encephalitis Virus(Cev) : a Computational Study Targeting Membrane Glycoproteins
Authors: Surendra Grandhi , Nelluri Kanaka Durga Devi , Male* CH K V L S N Anjana , Kamepalli Sahithi , Sharma Ashish Kumar , Nathiya Deepak , Singh Ravindra Pal , Alaparthi Bhavana , Kommoju Minakshi 
Published: July 2024

Abstract

California encephalitis is an uncommon viral brain infection that is caused by the California encephalitis virus (CEV).With encephalitis, the majority of patients experience full recovery with a mortality rate of less than 1%. A 20% or higher percentage of patients experience recurring seizures or behavioural issues. There is currently no vaccine or prescribed medication for California encephalitis, an infectious disease that is on the rise. Therefore, the development of a novel vaccination against CEV is imperative. The current study develops a vaccine based on many epitopes using immunoinformatic methods. B and T cell epitopes were predicted using the CEV membrane glycoprotein polyprotein as a target protein. The predicted T- and B-cell epitopes were then examined for conservancy, toxicity, allergenicity, and immunogenicity. HLA alleles were paired with screened epitopes to make sure they interacted to trigger an immune response. The best selected epitopes were used to create the vaccine. Studying the vaccine's physicochemical qualities and other features revealed its immunogenicity, stability, and safety. Afterwards, two Toll-like receptor-8 (TLR-8) was docked with the vaccination, and molecular dynamic simulations were examined. To ensure that the vaccine's codons would express themselves efficiently in a plasmid vector for in silico cloning tests, more codon adaptation of the vaccine sequence was carried out. It is predicted that the vaccine developed for this study will demonstrate its efficacy in controlling and preventing CEV .To make sure it's safe and effective, more in vivo and in vitro research needs to be done.
Early prediction of the microvascular invasion (MVI) occurrence in hepatocellular carcinoma (HCC) by 18 F-FDG PET/CT and laboratory data
Authors: Wang Tianyi , Chen Xue , Huang Huan , Jia Ningyang 
Published: July 2024

Abstract

Background: Hepatocellular carcinoma (HCC) is one of the most deadly malignant tumors in China. Microvascular invasion (MVI) of HCC often indicates poor prognosis and metastasis. 18F-FDG PET-CT is a new imaging method commonly used to screen tumor occurrence and evaluate tumor stage.
Purpose: The study attempted to predict the occurrence of MVI in HCC early through 18F-FDG PET/CT imaging findings and laboratory data.
Patients and methods: A total of 113 patients who accord with the inclusion criteria were divided into two groups based on postoperative pathological: MVI-positive group and MVI-negative group. We retrospectively analyzed the imaging findings and laboratory data of 113 patients. Imaging findings included tumor size, tumor maximum standard uptake value (SUVmaxT), normal liver maximum standard uptake value (SUVmaxL). calculate the ratio of SUVmaxT and SUVmaxL (SUVmaxT/L) and SUVmaxT/L>2 was defined as an active tumor metabolism. The tumor size was indicated by the maximum diameter of the tumor, with a diameter more than 5cm was defined as a mass lesion. laboratory data included alpha-fetoprotein (AFP) value and HBeAg level. AFP>20ug/L was defined as AFP high level. HBeAg>0.03NCU/mL was defined as HB-positive.
Result: SUVmaxT/L (p=0.003), AFP level (P=0.008) and tumor size (P=0.015) were statistically different between the two groups. Active tumor metabolism, mass lesion and AFP high level tend to be MVI positive. The consequences of binary logistic regression analysis verified active tumor metabolism (OR=4.124, 95%CI, 1.566-10.861, p=0.004) and high AFP level (OR=2.702, 95%CI, 1.214-6.021, p=0.015) were independent risk factors for MVI. The sensitivity of the combination of these two independent risk factors to predict HCC with MVI is 56.9% (29/51), the specificity is 83.9% (52/62) and the accuracy is 71.7% (81/113).
Conclusion: active tumor metabolism and high AFP level can predict the occurrence of MVI of HCC.
Placental chorionic plate DNA methylation patterns correlate with DNA methylation at SOCS3 in newborn human peripheral blood cells
Authors: Kashima Kohei , Kawai Tomoko , Ikemura Masako , Kamura Hiromi , Aoto Saki , Sato Taisuke , Motomura Kenichiro , Iriyama Takayuki , Nagamatsu Takeshi , Kondou Utako , Hyodo Hironobu , Okamura Kohji , Takahashi Naoto , Hata Kenichiro 
Published: July 2024

Abstract

Background
Regulation of placental function is fundamental for fetal development. Various in utero environments, including pregnancy complications, interfere with changes in DNA methylation and influence placental functions and child development following birth. However, data on the association between genome-wide DNA methylation patterns in the placenta and changes in DNA methylation in the postnatal peripheral blood cells of the same individuals remain limited. Herein, we aimed to reveal the association between epigenetic changes in fetal appendages at birth and longitudinal epigenetic changes in the tissues of neonates.
Methods
Using a DNA methylation array, we examined the epigenetics of placental chorionic plates from 136 participants who were born between 22 and 42 weeks of gestation. We then examined DNA methylation levels of 62 pairs of umbilical cord blood and postnatal peripheral blood cells to investigate their association with the epigenetics of chorionic plates in identical newborns.
Results
Unsupervised classification of chorionic plates by the most variable DNA methylation levels between samples revealed contrasting methylation patterns in the genes involved in blood vessel formation. The epigenetic classification of the chorionic plate was significantly associated with intrauterine inflammation, neonatal respiratory diseases, and DNA methylation levels of cg18181703 within the suppressor of the cytokine signaling 3 (SOCS3) gene in neonatal peripheral blood cells. A significant association between DNA methylation levels at cg18181703 in cord blood and the classification were nullified when gestational age at birth was considered as a covariate. Meanwhile, longitudinal methylation levels at cg18181703 were confirmed in the peripheral blood cells of neonates of specific groups classified by chorionic plate epigenetics, independent of gestational age.
Conclusions
DNA methylation patterns in chorionic plates during intrauterine inflammation were associated with DNA methylation levels of cg18181703 in neonates. Methylation of cg1818170 is known to have a causal effect on child height. Our study suggests that changes in chorionic plate function with DNA methylation changes may program infant growth via the DNA methylation levels of cg18181703 in blood cells.
Sex Differences in Mortality among Patients with Lupus Nephritis
Authors: Wang Wang , Xia Xi , Lu Yuewen , Zhang Xinxin , Shi Xiaolei , Jia Xiuzhi , Tang Ruihan , Chen Wei 
Published: July 2024

Abstract

Objective: To evaluate the prognostic importance of sex in lupus nephritis (LN).
Methods: A retrospective cohort of 921 biopsy-confirmed LN patients, diagnosed between 1996 and 2018, was analyzed. Demographics, clinical characteristics, laboratory findings, and renal pathology were assessed. The primary outcome was mortality, and the secondary outcomes included doubling of serum creatinine and end-stage renal disease (ESRD). Sex-associated risks were evaluated using Cox regression models.
Results: Among the 921 patients, 157 (17%) were male and 764 (83%) were female. Male patients exhibited more aggressive features: higher blood pressure, earlier disease onset, and elevated levels of serum creatinine (Scr), uric acid, blood urea nitrogen. Intriguingly, male patients also displayed more severe histopathological alterations, such as more karyorrhexis, cellular crescents/cellular fibrous crescents formations and tubular atrophy, even when overall renal pathology was comparable between sexes. During a median follow-up of 112 months, mortality was registered in 141 patients (15.3%). Mortality rates were conspicuously higher in males (24.2% males versus 13.4% females, P = 0.0029). Secondary outcomes did not show significant sex differences. Cox regression analysis highlighted male, age on renal biopsy, Scr, and Chronicity Index (CI) as independent risk factors for survival in LN patients. Notably, infections emerged as the leading cause of mortality among LN patients, with a significant higher rate in male patients.
Conclusion: In our cohort with LN, there was a higher rate of all-cause mortality and proportion of infection-related death in male. Recognizing and further exploring these sex disparities is crucial for optimized LN patient care.
Systematic Pan-Cancer Analysis Showed that P2RY13 was Associated with Immune Microenvironment and Prognosis
Authors: Li Zaishan , Meng Zhenzhen 
Published: July 2024

Abstract

P2RY13, a purinergic receptor belonging to the P2Y family of G-protein-coupled receptors, has garnered increasing attention for its potential involvement in cancer biology. This review explores the multifaceted role of P2RY13 in cancer development and progression, aiming to provide a comprehensive understanding of its implications for cancer diagnosis, prognosis, and therapy. Utilizing data mining techniques and bioinformatics analysis on publicly available datasets, we investigated the differential expression of P2RY13 across various cancer types and its correlation with clinical features, survival outcomes, tumor immune microenvironment, and molecular characteristics. Our analysis revealed significant dysregulation of P2RY13 expression in tumors, with distinct associations with malignant features and patient prognosis. Notably, P2RY13 expression was found to correlate with immune-related biomarkers and tumor stemness, highlighting its potential role in modulating tumor immunity and heterogeneity. Furthermore, our study identified correlations between P2RY13 expression and immune cell infiltration, immune checkpoint genes, and other immune regulatory genes, underscoring its importance in tumor immune modulation. Despite the insights gained, further mechanistic studies are warranted to elucidate the precise role of P2RY13 in cancer biology and to explore its therapeutic potential as a target for cancer treatment.
Evaluation of NSPRI Parabolic Shaped Solar Dryer (PSSD) for Drying of Tomatoes Under Semi-arid Climate Zone
Authors: Joel Jude , Alkali Abba Kaka , Ibrahim Bala , Ahmmad Adamu Abubakar , Babba Fatima Jamu , Dayo Oshadumo 
Published: July 2024

Abstract

This study evaluated the performance of a Parabolic Shaped Solar Dryer (PSSD) developed at Nigerian Stored Products Research Institute Kano (NSPRI) and compared it with an Open Sun Drying (OSD) - Ambient. The evaluation was carried out using Tomatoes (Eka). After sorting and washing the fresh tomatoes were sliced into 15 mm thickness and then spread on trays in PSSD and OSD. A thermo-hygrometer was used to record daily temperature and relative humidity. The dried Tomatoes' average drying temperature and relative humidity were 68.2 oC and 50.5% for PSSD, 47.5 oC, and 66.6% for OSD. The average drying rate was 31.6 kg/day for PSSD and 19.7 kg/day for OSD. The result showed that PSSD recorded the highest temperature variation and drying for drying of Tomatoes when compared to OSD. Initial moisture of 89.12% was reduced to a final moisture content of 14.5% for PSSD and 17.8% for OSD after six days of drying. Physiochemical and functional properties of the dehydrated tomato were also carried out. The bacteria count was lower in PSSD (5.8 x 103 Cfu/ml) compared to OSD (7.6 x 103 Cfu/ml). However, no fungal growth was observed in OSD where 4.1 x 103 Cfu/ml was recorded in PSSD.
H2S Signal Enhanced the hydrolysis of Seed Storage Globulins and Freezing Tolerance of Hydrated Brassica ( Brassica oleracea ) seeds
Authors: Han Yingying , Wang Jie , Li Liangbo , Song Danping , Li Weijie , Liu Baolin 
Published: July 2024

Abstract

Moisture content is the key factor that affects the freezing preservation of seeds. Previous studies have indicated that hydrolysis of seed storage globulins can enhance the freezing tolerance of hydrated seeds. Seed globulins are constituted by two subunits connected via disulfide bonds(-S-S-). As a donor for H2S, NaHS can act as a nucleophile to attack the disulfide bond of proteins and promote S-persulfidation. In this study, hydrated brassica (Brassica oleracea) seeds were treated with NaHS (5 mM) to confirm the role of the reduction the disulfide bonds of seed globulins on the freezing tolerance of hydrated seeds. The results indicated that NaHS treatment increased seed viability after slow cooling (NaHS vs. control: 55% vs. 38.3%) (P<0.05). Differential scanning calorimetry confirmed that supercooling occurred in embryos after NaHS treatment. NaHS treatment significantly increased the content of sulfhydryl groups in seed storage globulin, suggesting that NaHS promoted the reduction of disulfide bonds during slow cooling. Two-dimensional electrophoresis showed that NaHS promoted the depolymerization of seed storage globulins and accumulation of small polypeptides under slow cooling treatment. NaHS treatment also enhanced the levels of ascorbate and glutathione, which together make up an important antioxidant defense system against oxidative damage.
A survey of the frequency of polycystic ovary morphology in infertile patients with uterine abnormalities: a cross-sectional study
Authors: Irani Shohreh , Najafi Atiyeh , Vesali Samira , Mashayekhi Mehri , Niknejad Fatemeh , Ahmadi Firoozeh 
Published: July 2024

Abstract

Polycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. Several studies have shown an association between PCOS and Mullerian anomalies. This study aimed to evaluate the prevalence of polycystic ovary morphology (PCOM) in infertile patients with uterine anomalies (septate and arcuate uterine) who attended the Royan Research Institute in Tehran (Iran) between January 2021 and December 2022. The current cross-sectional study was conducted on a total of 884 infertile women who were referred to our Institute for 3D-hysterosonography. These women were divided into two groups: the first group consisted of 127 infertile women with uterine anomalies, while the second group included 757 infertile women without uterine anomalies. Information about the participants was extracted from their medical records at the Royan Research Institute. This study demonstrated that the frequency of PCOM in patients with uterine anomalies was 40.9% (52 women) and in those without such anomalies, it was 14/7% (111 women) (p = 0.0001). According to the study's findings, the prevalence of polycystic ovary morphology in women who have uterine anomalies is greater than that in women without these anomalies.
Study of the impact of operating parameters and the addition of fat on the physicochemical and texture properties of extruded snacks
Authors: Jacquet Nicolas , Plompteux Armande , Brostaux Yves , Malumba Paul , Danthine Sabine , Blecker Christophe 
Published: July 2024

Abstract

The present study focused on modelling and studying the effect of operating parameters and oil content of extrusion blends on the physicochemical and textural properties of snacks composed mainly of corn flour. A Box-Behnken response surface methodology design with three factors with three modalities was carried out. The effects of barrel temperature, extrusion screw speed and oil quantity added to the blends were investigated. This design made it possible to generate powerful models for several variables, allowing to predict snacks properties according to production conditions and to study in a efficient way the impact of production conditions on snacks properties. Results suggest a dominant effect of oil content which spoils the properties, while temperature and screw speed improve them. Strong correlations between some variables and a concordance of the observations were also highlighted. At the end, established models allowed to produce snacks with satisfactory properties by modulating the extrusion parameters.
Design of Resonant Cavity-Enhanced InAs/GaSb Superlattice LWIR Photodetector
Authors: Gong Ruixin , Zhu Lianqing , Feng Qingsong , Liu Zhiying 
Published: July 2024

Abstract

Type-II superlattices (T2SLs) have recently emerged as a focal point in long-wavelength infrared (LWIR) detection, showcasing remarkable potential across various applications. In this work, we have revealed a theoretical investigation into the band structure and optical properties of 14/7 ML InAs/GaSb SLs, employing density functional theory (DFT). Our findings show that the energy gap of these SLs is determined to be 0.111 eV through energy band structure analysis by the HSE06 method. Moreover, we have designed a resonant cavity-enhanced "Φ" structure for the 14/7 ML InAs/GaSb SLs infrared detector. This innovative design markedly enhances absorption efficiency, increasing it from 16.48% to an impressive 76.35% at the 11.2 µm wavelength. Further analysis includes a detailed examination of the electric field distribution within this structure and a comprehensive examination of the enhanced plasmonic resonator's perfect absorption phenomenon. The results from these analyses underscore the exceptional absorption capabilities of our resonant cavity-enhanced infrared detector, indicating its potential for significant applications in LWIR SLs focal plane.
Specific features of separations in fracture after CTOD tests of low-carbon microalloyed offshore steel S460MLO
Authors: Goli-Oglu Eugene , Palombo Marco , Filatov Andrei 
Published: July 2024

Abstract

Using the results of testing industrial batches of 23 mm steel heavy plates after thermomechanical rolling and subsequent post-weld heat treatment, the patterns of fatigue cracks formation in the fracture specimens during CTOD (Crack Tip Opening Displacement) testing for fracture toughness are investigated. Visual, microstructural, and fractographic studies of the nature of fracture formation and the surface of the secondary separations have been conducted. The probable causes of the manifestation of the potential «pop-in» effect on the load-displacement diagrams of the notch opening displacement are described, as well as its potentially negative impact on the interpretation of test results