bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of C-Reactive Protein, An Inflammatory Biomarker in The Development of Atherosclerosis and Its Treatment
Authors: Prasad Kailash 
Published: July 2024

AbstractThis article deals with the role of c-reactive protein (CRP) in the development of atherosclerosis and its treatment. CRP has a predictive value in ischemic heart disease, restenosis, coronary artery disease, aortic atherosclerosis, and cerebrovascular disease. This article deals with the synthesis and mechanism of CRP-induced atherosclerosis and its treatment. CRP increases the formation of numerous atherogenic biomolecules such as reactive oxygen species (ROS), cytokines (interleukin [IL]-1β and IL-6), cell adhesion molecules (intercellular adhesion molecule-1, vascular cell adhesion molecule-1, monocyte chemoattractant protein-1, activated complement C5, monocyte colony-stimulating factor, and numerous growth factors [insulin-like growth factor, platelet-derived growth factor, and transforming growth factor-β]). ROS mildly oxidizes low-density lipoprotein (LDL)-cholesterol to form minimally modified LDL which is further oxidized to form oxidized LDL. The above atherogenic biomolecules are involved in the development of atherosclerosis and has been described in detail in the text. This paper also deals with the treatment modalities for CRP-induced atherosclerosis which includes lipid-lowering drugs, antihypertensive drugs, antioxidants, aspirin, antidiabetic drugs, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, regular physical activity, weight reduction, and stoppage of cigarette smoking. In conclusion, CRP induces atherosclerosis through increases in atherogenic biomolecules and the treatment modalities would prevent, regress, and slow the progression of CRP-induced atherosclerosis.
Histopathological Study of Gastric Adenocarcinoma with Special Reference to Expression of HER2/neu and Ki-67 Assessed by Immunohistochemistry
Authors: Nisar Saiqa , Naskar Sukla , Biswas Saumitra 
Published: July 2024

Abstract
Introduction Gastric cancer has become the third leading cause of cancer deaths globally. It accounts for 5.7% of cancer around the world, with a rate of mortality around 8.2%. Evaluation of human epidermal growth factor receptor 2 (HER2)/neu overexpression for targeted therapies is presently the mainstay of treatment in gastric cancer. High Ki-67 index expression in gastric cancer is an indicator of poor prognosis.
Objectives To study the prevalence of HER2/neu expression and Ki-67 index in various types, sites, grade, and stage of gastric adenocarcinoma and to determine the correlation between HER2/neu expression and Ki-67 index.
Materials and Methods This is a prospective study in a tertiary care hospital, Kolkata from January 2019 to June 2020. Gastrectomy and endoscopic biopsy of gastric adenocarcinoma were studied for histopathology and immunohistochemistry (HER2/neu and Ki-67 index). Statistical analysis used: SPSS (version 21.0, IBM, Chicago, Illinois, United States) for windows software.
Results Among 54 cases, most of them were intestinal type, antral, moderately differentiated, stage III cases. HER2 expression and high Ki-67 index were observed in 28.0 and 40.75% cases, respectively. Statistically significant correlation was found in both HER2 expression and high Ki-67 index with location of the tumor and pathological nodal (pN) stage. A positive correlation was found between HER2/neu score and Ki-67 index (p = 0.007) (correlation coefficient = 0.4).
Conclusion A positive correlation was found between HER2/neu positivity and high Ki-67 index, both were associated with higher pathological tumor stage and pN stage. So, advanced cases may be considered for targeted therapy using trastuzumab.
Parameters identification and contact interaction control of redundant robot based on dynamic model
Authors: Li Yu , Bian Hao , Wang Liang 
Published: July 2024

Abstract
Human-redundant robot contact interaction control based on joint current is conducted. This is a sensorless control method. The key issues involved are dynamic parameters identification and interaction control strategy of robot. Firstly, kinematics model and linear dynamic model of robot are established and dynamic parameter matrix to be identified is obtained. Pattern search method is adopted to optimize motion trajectory of robot. Dynamic parameters is obtained by using least square method. The results indicate that the calculated current has a consistent trend with actual measured value, and the current error is small. In order to achieve independent control in null space, motion decoupling model of robot is established, and impedance control is applied to null space. When the force is applied to robot, based on impedance control and joint current changes, robot can move along the force direction, so the motion in null space can be controlled. Aiming at null space contact control during end force control task, comprehensive interaction control based on force sensor and joint current is conducted. The results show that robot can also move in compliance with human hand and achieve compliant interaction of null space when force is applied to the joint space.
Predictive modeling and optimization of Rockwell hardness of additively manufactured PEEK using RSM, ANFIS and RNN integrated with PSO
Authors: Borah Jyotisman , Chandrasekaran M 
Published: July 2024

Abstract
The purpose of this research is to investigate the correlation between statistical and machine learning techniques and additive manufacturing, with a specific focus on predicting the Rockwell hardness of FDM-printed polyether ether ketone (PEEK) components. These components have a significant impact on various industries, such as aerospace, biomedical, and automobile. The study analyzes the hardness by conducting experimental analysis of four process parameters, including infill density, layer height, printing speed, and infill pattern. The research utilizes Response Surface Methodology (RSM), Adaptive Neuro-Fuzzy Inference System (ANFIS), and Recurrent Neural Network (RNN) to accurately predict the Rockwell hardness of the printed parts, with an average deviation of less than 5% from the experimental value. The study also investigates how hardness varies with FDM process parameters using contour and surface plots. Furthermore, the study utilizes RNN integrated with the Particle Swarm Optimization (PSO) algorithm to optimize Rockwell hardness. This approach achieved a peak Rockwell hardness value of 66.89 RHN under conditions of 80% infill density, 0.1mm layer height, 25 mm sec−1 printing speed, and an octet infill pattern. Microstructural examinations and test results corroborate the findings derived from parametric analysis and optimization efforts.
A secure communication scheme based on generalized modified projective synchronization of a new 4-D fractional-order hyperchaotic system
Authors: Nabil Haneche , Tayeb Hamaizia 
Published: July 2024

Abstract
This paper focuses on the exploration of the chaotic behavior of a new 4-D fractional-order hyperchaotic system with five nonlinearities. The Adomian decomposition method is employed to solve the fractional-order hyperchaotic system. The stability of equilibrium points in this system is analyzed. Through bifurcation diagrams, Lyapunov exponent spectra, chaotic attractors, 0-1 test, C
0 complexity, and spectral entropy, the chaotic dynamics of the proposed system are investigated. Using these tools, we demonstrate the fractional-order system’s sensitivity to variation in both the derivative order and initial conditions. Moreover, a modified generalized projective synchronization is developed to implement chaos synchronization between two coupled fractional-order hyperchaotic systems. Furthermore, this work presents an application of synchronization scheme in secure communication. Numerical simulations were implemented to validate the effectiveness of the proposed secure communication scheme.
Stability of bright solitons in optical system supported by cubic and quintic nonlinearities with

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-symmetric quartic harmonic complex potential
Authors: Jaseera C P , Muhsina K Aysha , Thasneem A R 
Published: July 2024

Abstract
This work analyzed the existence and stability of optical waves in linear and nonlinear media with self-focusing cubic-quintic nonlinearity by way of interactions of nonlinearity, spatial diffraction, and parity-time (

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) symmetric complex potential defined by quartic harmonic real potential and Gaussian imaginary distribution. We demonstrated that the order of nonlinear function, the width and depth of the real potential, and the coefficient of diffraction modify the span of the complex potential parameter onto which

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-symmetry breakdown occurs. The region of stable

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-symmetry in the self-focusing medium improves as the order of the nonlinear function increases, as demonstrated by comparing the soliton solutions with cubic and quintic nonlinearities. We addressed the nonlinear evolution of the stable and unstable

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solitons under propagation. The linear stability of bright solitons is extensively studied and established the conditions for stable soliton for both

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−

symmetric and broken

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−

symmetric regions.
Moderate nitrogen enrichment increases CO2 sink strength in a coastal wetland
Authors: Qu Wendi , Han Guangxuan , Penuelas Josep , Wang Xiaoyue , Xie Baohua 
Published: July 2024

Abstract
Coastal wetlands remarkably influence terrestrial carbon (C) stock by serving as natural reservoirs for ‘blue carbon’. Anthropogenic nitrogen (N) enrichment shapes the dynamics of soil and plant communities, consequently affecting the C balance and ecosystem functions. The impacts of various levels of N enrichment on CO2 sequestration in coastal wetlands, however, remain elusive. Here we conducted a long-term field study of N fertilization in a coastal wetland in the Yellow River Delta, China, to investigate N effects on soil properties, indicators of plant dynamics, and fluxes of ecosystem CO2. The results indicated that moderate N enrichment (5 g N m−2 y−1) stimulated C fluxes with increases in gross primary productivity (+26.4%), ecosystem respiration (+23.3%), and net ecosystem exchange (NEE, +31.5%) relative to the control. High (10 g N m−2 y−1) and extreme (20 g N m−2 y−1) amounts of N enrichment, however, had relatively minor impacts on these CO2 fluxes. Overall, we observed a decrease in soil electrical conductivity (−24.6%) and increases in soil organic C (+25.2%) and microbial biomass C (+369.3%) for N enrichment. N enrichment also altered the composition of plant species, with a higher proportion of a local dominant species (Phragmites australis), and affected root biomass distribution, with more biomass near the soil surface. Structural equation modeling explained 65.2% of the variance of NEE and supported the assumption that N enrichment could alter the dynamics of soil properties and plant conditions and accelerate ecosystem CO2 sequestration. These findings have important implications for forecasting the C cycle with increasing N deposition in coastal wetlands, contributing to the projections of the global C budget.
Sustainability analysis using multi-dimensional scaling approach in Cilember Tourism Village, Bogor Regency
Authors: Ardiansyah I , Iskandar H , Krisnadi A R 
Published: July 2024

Abstract
Bogor Regency is renowned for its beautiful natural destinations and is known to have many Tourism Villages, with one of the most popular locations being Cilember Tourism Village located in the Cisarua district. This study aims to analyze the sustainability of Cilember Tourism Village in developing its tourism activities from economic, social, and ecological dimensions. The research method employed is quantitative descriptive, with data collection conducted through primary and secondary sources. The collected data is then analyzed using Multidimensional Scaling (MDS) with a Rap-Tourism approach, leveraging analysis, and Monte Carlo analysis. The analysis using Multidimensional Scaling with the Rap-Tourism approach, leverage analysis, and Monte Carlo analysis indicates the sustainability index of Cilember Tourism Village across the three dimensions using 21 indicators. The sustainability analysis results in an average score of 64.15 across the three dimensions, falling within the range of 50-74.9, indicating a moderate sustainable outcome.
Tourism village development for sustainable tourism in West Java-Indonesia (hexa helix tourism collaboration perspective)
Authors: Kartika T , Edison E , Maryani E 
Published: July 2024

Abstract
Tourism has a very important contribution to national development. West Java, one of the provinces in Indonesia has extraordinary tourism potential both natural, cultural, historical, and artificial. This study aims to analyze how stakeholders are involved in the Hexa Helix perspective (ABGCMT-Academician, Business, Government, Community, Media, and Tourist) in developing tourism that is sustainable in relation to the growth of tourism villages. This study used a descriptive qualitative method. Data collection techniques include literature studies, observations, and interviews with stakeholders related to tourism. The results of the study show that the Hexa Helix approach which involves six sectors, namely the government, business, academics, community, media, and tourist sectors is very important in the development of sustainable tourism. The resulting strategic recommendations include the need for policies to increase community participation in the management of tourist villages, strengthening the role of each Hexa Helix sector through program integration that supports sustainable tourism village development, and the need for training programs to improve the quality of human resources in the tourism sector, especially in a tourism village.
Developing forest farmer groups as tourism managers (study case: Cisuren forest farmer groups in Tugu Utara Village, Puncak Bogor)
Authors: Saputra F , Kamilah K 
Published: July 2024

Abstract
This paper investigates the innovative concept of harnessing the expertise and stewardship of forest farmer groups to manage tourism in forested areas, study case: Cisuren Forest Farmers Group in Curug Watugede. Through illustrative examples and in-depth analysis, it highlights the transformative impact of this initiative on both local communities and the preservation of forest ecosystems. This paper shows the steps in developing forest farmer group as tourism manager; such as 1) assessment planning, 2) capacity building and training, 3) infrastructure development, 4) marketing and promotion, 5) implementation, 6) monitoring and evaluation. This paper also discovers the challenges un developing forest farmer group as tourism manager; such as; 1) lack of financial resources, 2) limited technical experience, 3) seasonal visitor flow, 4) community resistance, and 5) slow initial growth. For each challenges, the solutions provided are external funding planning, capacity building programs development, diversify attractions, and transparent communications to the communities.
Hazard mapping in Sembalun-Senaru hiking trail, Mount Rinjani National Park
Authors: Jasthin R , Harini E K S , Primasatya R F 
Published: July 2024

Abstract
Visitors primarily prioritise safety and security while selecting a tourist site, such as Mount Rinjani National Park (3726 masl), which is known for its mountaineering activities. It is necessary to do a mapping of the possible hazard due to the fact that the earthquake in August 2018 caused significant changes to the landscape of the hiking trail. The objective of this study is to analyse and evaluate possible dangers and provide suggestions for managing risks on the Sembalun-Senaru hiking trail in Mount Rinjani National Park (MRNP). The data was gathered by field observations, interviews, and a review of relevant literature. The analysis of physical and biological hazard data is associated with the United Nations Environment Programme (UNEP), while the analysis of human activity hazard data is associated with the National Patient Safety Agency (NPSA). The hazards present in the area include seismic events, mass movements, volcanic eruptions, wildfires, gorges, precipitous trails, cold temperatures, fog, wildlife encounters, plant-related dangers, and human activities. The hazards with the highest risk values include steep pathways (physical), tree roots (biological), and jogging (human). Preventing hazards is achieved by enhancing climbers’ and the public’s understanding of risks through outreach, education, and simulations, as well as by enhancing the quality and adding necessary infrastructure. The curative activity is implemented by establishing precise operational standards for managing accidents and transportation.
Green curriculum in vocational studies for responsible tourism
Authors: Utari S K D , Mardiastuti A , Wahyudin D , Sunkar A 
Published: July 2024

Abstract
The travel, tourist, and hospitality industries have a large carbon footprint, so high school graduates must learn ethical tourism skills. Tourism’s future expansion, administration, and enjoyment depend on these graduates. Curriculum determines these abilities’ content. Due to its lack of emphasis on environmental preservation and morality, the current curriculum lacks environmental awareness and understanding. The objective of this study is to provide a clear understanding and enlightenment on the significance of incorporating an environmentally friendly curriculum in professional education. This research emphasises a green curriculum by including ecology and environment into education. It hopes to improve students’ understanding, potential, and sense of responsibility for the environment’s long-term survival. The research was conducted in two vocational high schools, which the government has designated as excellence centres. The study used direct observation, semi-structured interviews, questionnaire-based interviews, and a literature review. The study emphasises the significance of incorporating conservation education into vocational high school autonomous curricula to improve pedagogical integration and curriculum innovation. If environmental issues are taught, a generation with great ecological literacy will result.
Solid waste generation in selected Indonesian nature tourism parks and the proposed management strategies
Authors: Yuwono A S , Harnowo H , Batubara E R P , Wijianto A , Joharudin  , Kadyonggo E 
Published: July 2024

Abstract
Natural tourism parks are one place where visitors generate solid waste from their diverse activities. The purpose of this study is to develop an effective solid waste management plan for Indonesian natural tourist attractions. The preparation of the management strategy is based on the identification and classification of waste generation following national standards [SNI 19-3694-1994]; the outcomes take the form of data describing the percentage of most of the solid waste generation and its quantity. The appropriate treatment system alternatives are developed based on the nature and identity of the waste, and the best solution is then chosen by taking resource availability into account. The 20 natural tourism parks that were investigated had acceptable management practices that included processing (separation, transportation, processing, and final treatment) and reduction (generation restriction, recycling, and reuse). The organic portion of solid waste can be turned into commercial compost and protein feed, depending on the type of waste, while the inorganic portion can be transformed into fuel and concrete aggregate. Travelers should follow national waste management standards, which begin with prevention and continue via reduction, reuse, recycling, and other measures. Segregated waste will make the next waste management stage easier in the national park area.
Community readiness in the development of tourism products in Tamansari Village, Bogor Regency
Authors: Hanifah N , Rachmawati E , Hidayati S 
Published: July 2024

Abstract
Tamansari Village has been designated as a tourist village by the Bogor District Government. There are tourism products that the community offers. However, these products have yet to be able to support tourism development in the village because their quality still needs to improve in terms of variety and packaging. In this regard, it is necessary to identify factors that hinder product development in the village, including the community’s readiness to develop good tourism products. The research aims to analyze community readiness in developing tourism products. The research was conducted in Tamansari Village, Bogor Regency, in May-June 2022. Data was collected from 164 respondents through surveys. The research results show that most respondents (57%) want to be involved in developing tourism products, but less than 50% have knowledge (27.5%) and have abilities to develop tourism product development. As an implication, stakeholders need to make empowerment efforts to increase the knowledge and abilities of the Tamansari village community in developing good quality tourism products.
The role of social capital and individual competence on community resilience of the tourism industry against climate change
Authors: Idajati H , Damanik J , Kusworo H A , Rindrasih E 
Published: July 2024

Abstract
Climate change threatens the sustainability of tourism destinations characterized by increase frequency of flooding, coastal erosion, and ecosystem changes that result in infrastructure damage or decreased aesthetics of tourism destinations. This research aims to develop a conceptual model of community resilience to climate change based on two construct variables: social capital and individual competencies needed to strengthen tourism resilience to climate change in Gili Ketapang Island and Cacalan Beach. A quantitative approach was used by administering a questionnaire to 128 randomly selected respondents (tourism industry stakeholders) in coastal destinations in Indonesia. Data were analyzed using SEM-PLS to develop the model. The results showed that social capital and individual competence has a significant effect on the resilience of tourism community towards climate change in coastal tourist destinations. Social capital, including social networks and trust also has a significant effect on individual competence. Individual competence plays a mediating role in the influence of social capital on community resilience. Increased social capital and individual competence will strengthen community resilience. These findings can be applied to develop more appropriate resilience programs for tourism industry communities against climate change in the form of policies, training, and/or socialization to support the sustainability of tourism destinations.