bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of the Content and Quality in Briefs Instrument (CQB-I)
Authors: Elf Marie , Engström Maria Svedbo , Wijk Helle 
Published: February 2015

Objective: The Content and Quality in Briefs Instrument (CQB-I) was designed to develop a valid and reliable audit instrument to examine the content and quality of information in documents (briefs) created in the early stages of designing healthcare environments. Background: The importance of effective briefing has been emphasized in many research studies during the past two decades. However, there is no developed instrument for auditing the content and quality of these documents. Methods: The study had a methodological and developmental design based on an established methodology for instrument development and validation. The development process consisted of three main phases: (1) item generation and scale construction; (2) assessment of face and content validity, and (3) testing of the reliability. To obtain face and content validity, expert panels reviewed the CQB-I. Content validity was assessed using the Content Validity Index (I – CVI = item level, S – CVI = scale level). Reliability was tested by test-retest and inter-rater reliability. Results: CQB-I was found to have good content validity (I − CVI = 0.78–1.0 and S – CVI = 0.98). Inter-rater reliability was acceptable (Spearman's correlation = 0.62) and stability was considered high for both raters (83% and 88%, respectively).
Optimizing the Patient-Centered Environment
Authors: Locatelli Sara M. , Turcios Stephanie , LaVela Sherri L. 
Published: February 2015

Objective: To examine providers’ perspectives on the care environment and patient-centered care (PCC) through the eyes of the veteran patient, using guided tours qualitative methodology. Background: Environmental factors, such as attractiveness and function, have the potential to improve patients’ experiences. Participatory qualitative methods allow researchers to explore the environment and facilitate discussion. Methods: Guided tours were conducted with 25 health care providers/employees at two Veterans Affairs (VA) health care facilities. In guided tours, participants lead the researcher through an environment, commenting on their surroundings, thoughts, and feelings. The researcher walks along with the participant, asking open-ended questions as needed to foster discussion and gain an understanding of the participant’s view. Participants were asked to walk through the facility as though they were a veteran. Tours were audio recorded, with participant permission, and transcribed verbatim by research assistants. Three qualitative researchers were responsible for codebook development and coding transcripts and used data-driven coding approaches. Results: Participants discussed physical appearance of the environment and how that influences perceptions about care. Overall, participants highlighted the need to shed the “institutional” appearance. Differences between VA and non-VA health care facilities were discussed, including availability of private rooms and staff to assist with navigating the facility. They reviewed resources in the facility, such as the information desk to assist patients and families. Finally, they offered suggestions for future improvements, including improvements to waiting areas and quiet areas for patients to relax and “get away” from their rooms. Conclusions: Participants highlighted many small changes to the care environment that could enhance the patient experience. Additionally, they examined the environment from the patient's perspective, to identify elements that enhance, or detract from, the patient's care experience.
A randomized controlled study examining the effect of exercise on inflammatory cytokine levels in post-menopausal women
Authors: Tartibian Bakhtyar , FitzGerald Leah Z , Azadpour Noushin , Maleki Behzad Hajizadeh 
Published: February 2015

Background Elevated plasma levels of inflammatory cytokine are associated with body mass index, percent body fat and increased morbidity. Evidence suggests that higher levels of physical activity result in beneficial anti-inflammatory effects compared to a more sedentary lifestyle. Further, reproductive hormones are associated with inflammaotry cytokines. This study examined the effect of a 16-week low-moderate intensity exercise (EX) programme on reproductive hormones and inflammatory cytokines. Methods Twenty-eight healthy, sedentary post-menopausal women were randomly assigned to EX ( n = 14) or control (Con, n = 14) groups. The EX group completed low-moderate intensity treadmill training 25–30 min/day, up to 55% of HRmax, 3–4 days/week, for 16-weeks. Con maintained current physical activity level. Baseline and week-16 serum samples evaluated interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, C-reactive protein, estradiol, luteinizing hormone and follicular stimulating hormone. Results Post-intervention, the EX group showed a significant decrease in interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, estradiol, follicular stimulating hormone and luteinizing hormone levels compared to baseline values. No significant changes were observed in Con. Significant correlations were observed between IL-1β, IL-6, TNF-α, and reproductive hormones, both before and after the exercise intervention. Conclusion Findings suggest that a low-moderate intensity EX programme decreases cytokines in relation to reproductive hormones in post-menopausal women. These findings support the role of EX in reducing inflammatory markers and improved reproductive hormones in post-menopausal women.
p53 mediates loss of hematopoietic stem cell function and lymphopenia in Mysm1 deficiency
Authors: Belle Jad I. , Langlais David , Petrov Jessica C. , Pardo Mercedes , Jones Russell G. , Gros Philippe , Nijnik Anastasia 
Published: February 2015

Key Points
Developmental defects and impairment in lymphopoiesis in Mysm1-knockout mice are the result of p53 activation. Loss of hematopoietic stem cell function and bone marrow failure in Mysm1-knockout mice are the result of p53 activation.
Tyrosine kinase inhibitors induce mesenchymal stem cell–mediated resistance in BCR-ABL+ acute lymphoblastic leukemia
Authors: Mallampati Saradhi , Leng Xiaohong , Ma Haiqing , Zeng Jianfang , Li June , Wang Haiying , Lin Kevin , Lu Yue , Yang Yang , Sun Baohua , Gong Yun , Lee Ju-Seog , Konopleva Marina , Andreeff Michael , Arlinghaus Ralph B. , Cai Zhen , Fang Bingliang , Shen Haifa , Han Xin , Hirsch-Ginsberg Cheryl F. , Gao Xiaolian , Paranjape Anurag N. , Mani Sendurai A. , Clise-Dwyer Karen , Sun Xiaoping 
Published: February 2015

Key Points
TKI resistance can be caused by the action of TKIs on MSCs. Inhibition of the IL-7R/Janus kinase pathway diminishes TKI resistance in MSC milieu.
‘Hearts and minds’: association, causation and implication of cognitive impairment in heart failure
Authors: Cannon Jane A , McMurray John JV , Quinn Terry J 
Published: February 2015

AbstractThe clinical syndrome of heart failure is one of the leading causes of hospitalisation and mortality in older adults. An association between cognitive impairment and heart failure is well described but our understanding of the relationship between the two conditions remains limited. In this review we provide a synthesis of available evidence, focussing on epidemiology, the potential pathogenesis, and treatment implications of cognitive decline in heart failure. Most evidence available relates to heart failure with reduced ejection fraction and the syndromes of chronic cognitive decline or dementia. These conditions are only part of a complex heart failure-cognition paradigm. Associations between cognition and heart failure with preserved ejection fraction and between acute delirium and heart failure also seem evident and where data are available we will discuss these syndromes. Many questions remain unanswered regarding heart failure and cognition. Much of the observational evidence on the association is confounded by study design, comorbidity and insensitive cognitive assessment tools. If a causal link exists, there are several potential pathophysiological explanations. Plausible underlying mechanisms relating to cerebral hypoperfusion or occult cerebrovascular disease have been described and it seems likely that these may coexist and exert synergistic effects. Despite the prevalence of the two conditions, when cognitive impairment coexists with heart failure there is no specific guidance on treatment. Institution of evidence-based heart failure therapies that reduce mortality and hospitalisations seems intuitive and there is no signal that these interventions have an adverse effect on cognition. However, cognitive impairment will present a further barrier to the often complex medication self-management that is required in contemporary heart failure treatment.
Angiotensin-(1-7) improves oxygenation, while reducing cellular infiltrate and fibrosis in experimental Acute Respiratory Distress Syndrome
Authors: Zambelli Vanessa , Bellani Giacomo , Borsa Roberto , Pozzi Federico , Grassi Alice , Scanziani Margherita , Castiglioni Vittoria , Masson Serge , Decio Alessandra , Laffey John G , Latini Roberto , Pesenti Antonio 
Published: February 2015

Abstract

Background
The renin-angiotensin system (RAS) plays a role in the pathogenesis of ARDS, Angiotensin II (Ang-II) contributing to the pathogenesis of inflammation and fibrogenesis. Angiotensin-(1-7) (Ang-(1-7)) may antagonize the effects of Ang-II. This study was aimed at evaluating the potential for Ang-(1-7) to reduce injury, inflammation and fibrosis in an experimental model of ARDS in the acute and late phases.

Methods
Male Sprague Dawley rats underwent an instillation of 0.1 M hydrochloric acid (HCl, 2.5 ml/kg) into the right bronchus. In an acute ARDS study, acid-injured rats were subjected to high stretch mechanical ventilation (18 ml/kg) for 5 h and randomized to receive an intravenous infusion of either vehicle (saline), Ang-(1-7) at low dose(0.27 μg/kg/h) (ALD), or high dose (60 μg/kg/h) (AHD) starting simultaneously with injury or 2 h afterwards. Arterial blood gas analysis and bronchoalveolar lavage (BAL) were performed to assess the injury. For the late ARDS study, after HCl instillation rats were randomized to either vehicle or high dose Ang-(1-7) (300 μg/kg/day) infused by mini osmotic pumps for two weeks, and lung hydroxyproline content measured.

Results
In the acute ARDS study, Ang-(1-7) led to a significant improvement in oxygenation (PaO2/FiO2 : vehicle 359 ± 86; ALD 436 ± 72; AHD 44 442 ± 56; ANOVA p = 0.007) and reduced white blood cells counts (vehicle 4,519 ± 2,234; ALD 2,496 ± 621; AHD 2,744 ± 119/mm3; ANOVA p = 0.004). Only treatment with high dose Ang-(1-7) reduced inflammatory cell numbers in BAL (vehicle 127 ± 34; AHD 96 ± 34/ μl; p = 0.033). Interestingly also delayed administration of Ang-(1-7) was effective in reducing injury. In later ARDS, Ang-(1-7) decreased hydroxyproline content (649 ± 202 and 1,117 ± 297 μg/lung; p < 0.05).

Conclusions
Angiotensin-(1-7), decreased the severity of acute lung injury and inflammation induced by combined acid aspiration and high stretch ventilation. Furthermore, continuous infusion of Ang-(1-7) reduced lung fibrosis 2 weeks following acid aspiration injury. These results call for further research on Ang-(1-7) as possible therapy for ARDS.
Δ9-Tetrahydrocannabinol-mediated epigenetic modifications elicit myeloid-derived suppressor cell activation via STAT3/S100A8
Authors: Sido Jessica Margaret , Yang Xiaoming , Nagarkatti Prakash S , Nagarkatti Mitzi 
Published: February 2015

Abstract
MDSCs are potent immunosuppressive cells that are induced during inflammatory responses, as well as by cancers, to evade the anti-tumor immunity. We recently demonstrated that marijuana cannabinoids are potent inducers of MDSCs. In the current study, we investigated the epigenetic mechanisms through which THC, an exogenous cannabinoid, induces MDSCs and compared such MDSCs with the nai¨ve MDSCs found in BM of BL6 (WT) mice. Administration of THC into WT mice caused increased methylation at the promoter region of DNMT3a and DNMT3b in THC-induced MDSCs, which correlated with reduced expression of DNMT3a and DNMT3b. Furthermore, promoter region methylation was decreased at Arg1 and STAT3 in THC-induced MDSCs, and consequently, such MDSCs expressed higher levels of Arg1 and STAT3. In addition, THC-induced MDSCs secreted elevated levels of S100A8, a calcium-binding protein associated with accumulation of MDSCs in cancer models. Neutralization of S100A8 by use of anti-S100A8 (8H150) in vivo reduced the ability of THC to trigger MDSCs. Interestingly, the elevated S100A8 expression also promoted the suppressive function of MDSCs. Together, the current study demonstrates that THC mediates epigenetic changes to promote MDSC differentiation and function and that S100A8 plays a critical role in this process.
Store-operated calcium signaling in neutrophils
Authors: Clemens Regina A , Lowell Clifford A 
Published: February 2015

Abstract
Calcium signals in neutrophils are initiated by a variety of cell-surface receptors, including formyl peptide and other GPCRs, FcRs, and integrins. The predominant pathway by which calcium enters immune cells is termed SOCE, whereby plasma membrane CRAC channels allow influx of extracellular calcium into the cytoplasm when intracellular ER stores are depleted. The identification of 2 key families of SOCE regulators, STIM calcium “sensors” and ORAI calcium channels, has allowed for genetic manipulation of SOCE pathways and provided valuable insight into the molecular mechanism of calcium signaling in immune cells, including neutrophils. This review focuses on our current knowledge of the molecules involved in neutrophil SOCE and how study of these molecules has further informed our understanding of the role of calcium signaling in neutrophil activation.
Randomized Phase III Trial of Gemcitabine Plus Docetaxel Plus Bevacizumab or Placebo As First-Line Treatment for Metastatic Uterine Leiomyosarcoma: An NRG Oncology/Gynecologic Oncology Group Study
Authors: Hensley Martee L. , Miller Austin , O'Malley David M. , Mannel Robert S. , Behbakht Kian , Bakkum-Gamez Jamie N. , Michael Helen 
Published: February 2015

Purpose Fixed-dose rate gemcitabine plus docetaxel achieves objective response in 35% of patients with uterine leiomyosarcoma (uLMS). This study aimed to determine whether the addition of bevacizumab to gemcitabine-docetaxel increases progression-free survival (PFS) in uLMS. Patients and Methods In this phase III, double-blind, placebo-controlled trial, patients with chemotherapy-naive, metastatic, unresectable uLMS were randomly assigned to gemcitabine-docetaxel plus bevacizumab or gemcitabine-docetaxel plus placebo. PFS, overall survival (OS), and objective response rates (ORRs) were compared to determine superiority. Target accrual was 130 patients to detect an increase in median PFS from 4 months (gemcitabine-docetaxel plus placebo) to 6.7 months (gemcitabine-docetaxel plus bevacizumab). Treatment effects on PFS and OS were described by hazard ratios (HRs), median times to event, and 95% CIs. Results In all, 107 patients were accrued: gemcitabine-docetaxel plus placebo (n = 54) and gemcitabine-docetaxel plus bevacizumab (n = 53). Accrual was stopped early for futility. No statistically significant differences in grade 3 to 4 toxicities were observed. Median PFS was 6.2 months for gemcitabine-docetaxel plus placebo versus 4.2 months for gemcitabine-docetaxel plus bevacizumab (HR, 1.12; P = .58). Median OS was 26.9 months for gemcitabine-docetaxel plus placebo and 23.3 months for gemcitabine-docetaxel plus bevacizumab (HR, 1.07; P = .81). Objective responses were observed in 17 (31.5%) of 54 patients randomly assigned to gemcitabine-docetaxel plus placebo and 19 (35.8%) of 53 patients randomly assigned to gemcitabine-docetaxel plus bevacizumab. Mean duration of response was 8.6 months for gemcitabine-docetaxel plus placebo versus 8.8 months for gemcitabine-docetaxel plus bevacizumab. Conclusion The addition of bevacizumab to gemcitabine-docetaxel for first-line treatment of metastatic uLMS failed to improve PFS, OS, or ORR. Gemcitabine-docetaxel remains a standard first-line treatment for uLMS.
Features of Educational Process under the Formation of Diagnostic Competences of Masters in Speech Therapy
Authors: ��������  , Logunova Elena , ��������  , Levchenko Irina 
Published: February 2015

The article is devoted to the peculiarities of �Speech Pathology Education� Ph.D. program against the reforms of the education of persons with disabilities.
The work implements competency-based approach to the preparation of students for the Master?s program. Competences of the Master of
psychological-pedagogical diagnostics and one�s activities in the field of integrated studying of persons with disabilities, as well as of teaching and
research activities, are described. To assess the development of diagnostic competence authors developed and submitted tasks of different levels of
complexity, allowing to assess competence at different stages of learning. The article presents an innovative technology of application of a &#34;Portfolio&#34;
didactic method in the formation of diagnostic competence, describes the contents of the �Portfolio� (created by the magistrand), and provides evaluation
criteria for the performance of the proposed technology.
Composing the technology of students� self-monitoring in extracurricular activities under FSES PGE
Authors: �������  , Ivanova Irina 
Published: February 2015

Article has actual scientific issues associated with the detection capabilities of technology monitoring self-identity in the context of quality management
of modern education. The article raises the question of design, implementation and monitoring technology sense of self-development of younger
schoolboys in the development of GEF primary education in extracurricular activities, the methodology and technology tools for its implementation.
The proposed self-monitoring technology students in extracurricular activities under the GEF primary education takes into account the requirements
of the Government of the Russian Federation &#34;On the implementation of the monitoring system of education&#34; and the requirements for the results of
development of the basic educational program of primary education, as reflected in the standards.
In the construction of monitoring technology self-development of students in extracurricular activities is reflected not only the elements of the external,
but internal components of the evaluation of the quality of education, not only standardized procedures (tests, the test work, etc.), but also new methods
of assessment that reflect personal achievement and personal growth of the child.
The article demonstrates in detail the sequence of technological development of self-monitoring technology in children&#180;s extracurricular activities,
spelled out the procedural part of the study. The author suggests a diagnostic toolkit self-development of students for various educational programs;
authoring: route book pupil, which made monitoring data and recommendations are fixed educator and psychologist; student book &#34;I Know thyself&#34;, its
analysis will allow psychologists and educators to make the route of individual self-development of the child. Their use in the practice of the educational
process will produce trending self-identity of the student and to determine effective means to ensure that emphasizes the importance of the results
obtained in relation to each child.
The implementation of self-monitoring technology students in extracurricular activities under the GEF implementing primary education will improve the
quality of students&#180; extracurricular activities, as well as provide the ability to control the process of self-development based on analysis of data obtained
from monitoring.
The developed technology has found its application in the educational space of non-formal education of the city of Kaluga and Kaluga region.
The article may be of interest to elementary school teachers, employees of additional education of children, psychologists, teaching staff of educational
organizations implementing self-monitoring of students.
The Polish Adaptation of the Public Speaking Anxiety Questionnaire
Authors: Chodkiewicz Jan , Miniszewska Joanna 
Published: February 2015

CelCelem przeprowadzonych badań było dokonanie polskiej adaptacji skróconego Kwestionariusza Lęku przez Wystąpieniami Publicznymi GFER Spitznagla i współpracowników.MetodaKwestionariusz GFER jest metodą samooceny składającą się z 16 twierdzeń i przeznaczoną do oceny emocji i reakcji fizjologicznych oraz myśli pojawiających się w sytuacji wystąpienia publicznego. Za pomocą Kwestionariusza GFER zbadano 320 studenów łódzkich uczelni (medycyny, prawa i psychologii). Zastosowano również Inwentarz Stanu i Cechy Lęku Spielbergera, Skalę Lęku i Depresji HADS Zigmunta i Snaitha oraz TCI CloningeraWynikiPolska wersja Kwestionariusza GFER charakteryzuje się dobrymi właściwościami psychometrycznymi - jest narzędziem rzetelnym i trafnym. W wyniku przeprowadzonych analiz uzyskano 9-itemową wersję narzędzia o dwuczynnikowej strukturze - czynnik I to reakcje emocjonalne i fizjologiczne, czynnik II - zamartwianie się. Metoda wykazuje istotne statystycznie związki z poziomem lęku jako stanu i cechy oraz temperamentalnym wymiarem unikania szkodyWnioskiRezultat przeprowadzonych prac nad adaptacją Kwestionariusza GFER Spitznagla i współpracowników przemawia za rekomendowaniem metody do dalszych badań naukowych oraz zastosowania w praktyce terapeutycznej.
Neovascularisation is not an Innocent Bystander in Recurrence after Great Saphenous Vein Surgery
Authors: Corbett CRR , Prakash V 
Published: February 2015

Introduction This study sought to establish the causes of failure of great saphenous vein surgery among patients in whom there was confidence that accurate saphenofemoral ligation had been carried and the great saphenous vein had been stripped at least to knee level. Methods This was an observational study of 100 limbs (66 patients) operated on by a single surgeon 5–22 years previously (mean: 12 years). The index operation was primary in 54 limbs and for recurrence in 46 limbs. Thirty-two patients were studied having been re-referred for recurrence while 34 were recalled for review. All were examined clinically and with duplex ultrasonography, and all completed questionnaires (Aberdeen varicose vein questionnaire [AVVQ] and EQ-5D-3L). In order to measure the extent of visible recurrence, a scoring system similar to that in the venous clinical severity score was used but with a range of 0–8. Results There were visible varicosities in 77 of the 100 limbs. Duplex ultrasonography showed that recurrent saphenofemoral incompetence (SFI) was present in 27% of the limbs. This was judged to result from neovascularisation and was the most common source of reflux. AVVQ scores for the 27 limbs with recurrent SFI (median: 34, interquartile range [IQR]: 20–42) were higher than for the 73 with no recurrent SFI (median: 17, IQR: 11–29), which was a significant difference (Mann–Whitney U test, p<0.01). Analysing clinical scores with chi-squared tests indicated fewer visible varicosities in limbs without recurrent SFI than in those with recurrent SFI (p<0.01). Conclusions Neovascularisation remains poorly understood but it cannot be considered an innocent bystander.