bluuebunny/crossref_metadata_2025_split huggingface dataset:
A chemically amplified molecular glass resist with an ionic photoacid generator and a single protection group
Authors: Kasai Tatsuaki , Higashihara Tomoya , Ueda Mitsuru 
Published: August 2013

ABSTRACTA molecular glass resist with an ionic photoacid generator and a single protection group (MR‐1) has been developed. MR‐1 exhibited good thermal properties, such as a 5% weight loss temperature (Td5%) of 167°C and a glass transition temperature (Tg) of 80°C. MR‐1 showed the good sensitivity of 80 μC/cm2 and high contrast of 4.9 with e‐beam exposure (50 keV). A relatively high resolution of 50 nm and low Line‐Edge‐Roughness of 3.8 nm were obtained by e‐beam exposure (100 keV). © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39769.
Oligonucleotides‐decorated‐poly(N‐vinyl pyrrolidone) nanogels for gene delivery
Authors: Dispenza Clelia , Adamo Giorgia , Sabatino Maria Antonietta , Grimaldi Natascia , Bulone Donatella , Bondì Maria Luisa , Rigogliuso Salvatrice , Ghersi Giulio 
Published: August 2013

ABSTRACTPulsed electron‐beam irradiation of a semi‐dilute poly(N‐vinyl pyrrolidone) (PVP) aqueous solution in the presence of acrylic acid has led to a carboxyl functionalized nanogel system. Nanoparticles hydrodynamic size and surface charge density, in water and as a function of pH, were investigated by dynamic light scattering and laser doppler velocimetry, respectively. Nanogels (NGs) were proved not to be cytotoxic at the cellular level. Indeed, they rapidly bypass the cellular membrane to accumulate in specific cell portions of the cytoplasm, in the perinuclear area. The availability of pendant carboxyl groups on the crosslinked PVP NGs core prompted us to attempt their decoration with a single strand oligonucleotide, which holds a terminal amino group. The recognition ability of the attached single helix of its complementary strand was investigated. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2014,131, 39774.
Prevalence and trends of selected congenital malformations in New York state, 1983 to 2007
Authors: Kim Keewan , Wang Ying , Kirby Russell S. , Druschel Charlotte M. 
Published: August 2013

BACKGROUNDMajor birth defects result in high infant mortality and morbidity. It is important to evaluate the burden of birth defects and trends for future intervention and public health improvement. Using the New York State (NYS) Congenital Malformations Registry data, we examined the prevalence and trends of birth defects among children in NYS during 25 years of surveillance.METHODSChildren who had any of the 21 selected birth defects and were born to NYS residents between 1983 and 2007 were selected. The prevalence of each defect was characterized by demographic and birth factors, and the prevalence ratio was calculated. Live births of NYS residents for the same birth year period were used as the denominators for calculating the prevalence. The prevalence trends of birth defects were analyzed by maternal age and race/ethnicity.RESULTSCompared with non‐Hispanic whites, we detected 33%, 21%, and 37% higher prevalence of encephalocele, lower limb deficiencies and omphalocele among non‐Hispanic blacks, respectively, and 22% higher prevalence of gastroschisis among Hispanics. Increasing trends of gastroschisis and Down syndrome among non‐Hispanic blacks and decreasing trends of spina bifida and limb deficiencies were observed in NYS.CONCLUSIONThe findings from this study suggest the existence of racial disparities among children with selected birth defects in NYS. The increasing trends of gastroschisis and Down syndrome observed in NYS are consistent with nationwide trends. Birth Defects Research (Part A) 97:619–627, 2013. © 2013 Wiley Periodicals, Inc.
Folic acid fortification and the birth prevalence of congenital heart defect cases in Alberta, Canada
Authors: Bedard Tanya , Lowry R. Brian , Sibbald Barbara , Harder Joyce R. , Trevenen Cynthia , Horobec Vera , Dyck John D. 
Published: August 2013

BACKGROUNDCongenital heart defects (CHDs) are the most common type of congenital anomaly. The precise etiology is unknown and the development of successful primary prevention strategies is challenging. Folic acid may have a protective role; however published results have been inconsistent. This study examines the impact of mandatory folic acid fortification (FAF) on the prevalence of CHDs.METHODSCHD cases were ascertained using the Alberta Congenital Anomalies Surveillance System, Pediatric Cardiology Clinics, Pathology, and hospital records. The birth prevalence and odds ratios (OR) of isolated CHD cases (i.e., without noncardiac anomalies) were calculated comparing pre‐FAF (1995–1997) with post‐FAF (1999–2002).RESULTSThe prevalence of isolated CHD cases remained relatively unchanged when pre‐FAF (9.34, 95% confidence interval [CI] 8.79–9.92) was compared with post‐FAF (9.41, 95% CI, 8.93–9.91). Left ventricular outflow tract obstruction (LVOTO) decreased post‐FAF (OR, 0.76; 95% CI, 0.61–0.94). Coarctation of the aorta contributed to this decline (OR, 0.55; 95% CI, 0.32–0.92). Atrial septal defect (ASD) (OR, 1.42; 95% CI, 1.13–1.80) and ASD with ventricular septal defect (OR, 1.52; 95% CI, 1.10–2.10) increased post‐FAF. The remaining types of CHDs were unchanged.CONCLUSIONFAF alone does not have an impact on the prevalence of CHDs as a group and the majority of selected types of CHDs in Alberta. The decrease in LVOTO, particularly coarctation of the aorta, may be due to FAF or other environmental factors. The increase in ASD and ASD with ventricular septal defect may reflect an increase in diagnosis and ascertainment. Birth Defects Research (Part A) 97:564‐570, 2013. © 2013 Wiley Periodicals, Inc.
Exon sequencing of PAX3 and T (brachyury) in cases with spina bifida
Authors: Agopian A.J. , Bhalla Angela D. , Boerwinkle Eric , Finnell Richard H. , Grove Megan L. , Hixson James E. , Shimmin Lawrence C. , Sewda Anshuman , Stuart Colin , Zhong Yu , Zhu Huiping , Mitchell Laura E. 
Published: August 2013

BACKGROUNDBased on studies in animals and humans, PAX3 and T (brachyury) are candidate genes for spina bifida. However, neither gene has been definitively identified as a risk factor for this condition.METHODSSanger sequencing was used to identify variants in all PAX3 and T exons and promoter regions in 114 spina bifida cases. For known variants, allele frequencies in cases were compared with those from public databases using unadjusted odds ratios. Novel variants were genotyped in parents and assessed for predicted functional impact.RESULTSWe identified common variants in PAX3 (n = 2) and T (n = 3) for which the allele frequencies in cases were significantly different from those reported in at least one public database. We also identified novel variants in both PAX3 (n = 11) and T (n = 1) in spina bifida cases. Several of the novel PAX3 variants are predicted to be highly conserved and/or impact gene function or expression.CONCLUSIONThese studies provide some evidence that common variants of PAX3 and T are associated with spina bifida. Rare and novel variants in these genes were also identified in affected individuals. However, additional studies will be required to determine whether these variants influence the risk of spina bifida. Birth Defects Research (Part A) 97:597–601, 2013. © 2013 Wiley Periodicals, Inc.
Reduction of product‐related species during the fermentation and purification of a recombinant IL‐1 receptor antagonist at the laboratory and pilot scale
Authors: Schirmer Emily B. , Golden Kathryn , Xu Jin , Milling Jesse , Murillo Alec , Lowden Patricia , Mulagapati SriHariRaju , Hou Jinzhao , Kovalchin Joseph T. , Masci Allyson , Collins Kathryn , Zarbis‐Papastoitsis Gregory 
Published: August 2013

AbstractThrough a parallel approach of tracking product quality through fermentation and purification development, a robust process was designed to reduce the levels of product‐related species. Three biochemically similar product‐related species were identified as byproducts of host‐cell enzymatic activity. To modulate intracellular proteolytic activity, key fermentation parameters (temperature, pH, trace metals, EDTA levels, and carbon source) were evaluated through bioreactor optimization, while balancing negative effects on growth, productivity, and oxygen demand. The purification process was based on three non‐affinity steps and resolved product‐related species by exploiting small charge differences. Using statistical design of experiments for elution conditions, a high‐resolution cation exchange capture column was optimized for resolution and recovery. Further reduction of product‐related species was achieved by evaluating a matrix of conditions for a ceramic hydroxyapatite column. The optimized fermentation process was transferred from the 2‐L laboratory scale to the 100‐L pilot scale and the purification process was scaled accordingly to process the fermentation harvest. The laboratory‐ and pilot‐scale processes resulted in similar process recoveries of 60 and 65%, respectively, and in a product that was of equal quality and purity to that of small‐scale development preparations. The parallel approach for up‐ and downstream development was paramount in achieving a robust and scalable clinical process.
Distinction between hand dominance and hand preference in primates: a behavioral investigation of manual dexterity in nonhuman primates (macaques) and human subjects
Authors: Chatagny Pauline , Badoud Simon , Kaeser Mélanie , Gindrat Anne‐Dominique , Savidan Julie , Fregosi Michela , Moret Véronique , Roulin Christine , Schmidlin Eric , Rouiller Eric M. 
Published: August 2013

AbstractBackgroundThe present study aimed to determine and confront hand preference (hand chosen in priority to perform a manual dexterity task) and hand dominance (hand with best motor performance) in eight macaques (Macaca fascicularis) and in 20 human subjects (10 left‐handers and 10 right‐handers).MethodsFour manual dexterity tests have been executed by the monkeys, over several weeks during learning and stable performance phases (in controlled body position): the modified Brinkman board, the reach and grasp drawer, the tube and the bimanual board tasks. Three behavioral tests, adapted versions from the monkeys tasks (modified Brinkman board, tube and bimanual board tasks), as well as a handedness questionnaire, have been conducted in human subjects.ResultsIn monkeys, there was a large disparity across individuals and motor tasks. For hand dominance, two monkeys were rather right lateralized, three monkeys rather left lateralized, whereas in three monkeys, the different parameters measured were not consistent. For hand preference, none of the eight monkeys exhibited a homogeneous lateralization across the four motor tasks. Macaca fascicularis do not exhibit a clear hand preference. Furthermore, hand preference often changed with task repetition, both during training and plateau phases. For human subjects, the hand preference mostly followed the self‐assessment of lateralization by the subjects and the questionnaire (in the latter, right‐handers were more lateralized than left‐handers), except a few discrepancies based on the tube task. There was no hand dominance in seven right‐handers (the other three performed better with the right hand) and in four left‐handers. Five left‐handers showed left‐hand dominance, whereas surprisingly, one left‐hander performed better with the right hand. In the modified Brinkman board task, females performed better than males, right‐handers better than left‐handers.ConclusionsThe present study argues for a distinction between hand preference and hand dominance, especially in macaque monkeys.
A Study of Transition‐Metal Organometallic Complexes Combining 35Cl Solid‐State NMR Spectroscopy and 35Cl NQR Spectroscopy and First‐Principles DFT Calculations
Authors: Johnston Karen E. , O'Keefe Christopher A. , Gauvin Régis M. , Trébosc Julien , Delevoye Laurent , Amoureux Jean‐Paul , Popoff Nicolas , Taoufik Mostafa , Oudatchin Konstantin , Schurko Robert W. 
Published: August 2013

AbstractA series of transition‐metal organometallic complexes with commonly occurring metalchlorine bonding motifs were characterized using 35Cl solid‐state NMR (SSNMR) spectroscopy, 35Cl nuclear quadrupole resonance (NQR) spectroscopy, and first‐principles density functional theory (DFT) calculations of NMR interaction tensors. Static 35Cl ultra‐wideline NMR spectra were acquired in a piecewise manner at standard (9.4 T) and high (21.1 T) magnetic field strengths using the WURST‐QCPMG pulse sequence. The 35Cl electric field gradient (EFG) and chemical shielding (CS) tensor parameters were readily extracted from analytical simulations of the spectra; in particular, the quadrupolar parameters are shown to be very sensitive to structural differences, and can easily differentiate between chlorine atoms in bridging and terminal bonding environments. 35Cl NQR spectra were acquired for many of the complexes, which aided in resolving structurally similar, yet crystallographically distinct and magnetically inequivalent chlorine sites, and with the interpretation and assignment of 35Cl SSNMR spectra. 35Cl EFG tensors obtained from first‐principles DFT calculations are consistently in good agreement with experiment, highlighting the importance of using a combined approach of theoretical and experimental methods for structural characterization. Finally, a preliminary example of a 35Cl SSNMR spectrum of a transition‐metal species (TiCl4) diluted and supported on non‐porous silica is presented. The combination of 35Cl SSNMR and 35Cl NQR spectroscopy and DFT calculations is shown to be a promising and simple methodology for the characterization of all manner of chlorine‐containing transition‐metal complexes, in pure, impure bulk and supported forms.
Ultrasound Stimulated Nucleation and Growth of a Dye Assembly into Extended Gel Nanostructures
Authors: Malicka Joanna M. , Sandeep Anjamkudy , Monti Filippo , Bandini Elisa , Gazzano Massimo , Ranjith Choorikkat , Praveen Vakayil K. , Ajayaghosh Ayyappanpillai , Armaroli Nicola 
Published: August 2013

AbstractA squaraine dye functionalized with a bulky trialkoxy phenyl moiety through a flexible diamide linkage (GA‐SQ) capable of undergoing self‐assembly has been synthesized and fully characterized. Rapid cooling of a hot solution of GA‐SQ to 0 °C results in self‐assembled precipitates consisting of two types of nanostructures, rings and ill‐defined short fibers. The application of ultrasound modifies the conditions for the supersaturation‐mediated nucleation, generating only one kind of nuclei and prompting the formation of crystalline fibrous structures, inducing gelation of solvent molecules. The unique self‐assembling behavior of GA‐SQ under ultrasound stimulus has been investigated in detail by using absorption, emission, FT‐IR, XRD, SEM, AFM and TEM techniques. These studies reveal a nucleation growth mechanism of the self‐assembled material, an aspect rarely scrutinized in the area of sonication‐induced gelation. Furthermore, in order to probe the effects of nanoscale substrates on the sonication‐induced self‐assembly, a minuscule amount of single‐walled carbon nanotubes was added, which leads to acceleration of the self‐assembly through a heterogeneous nucleation process that ultimately affords a supramolecular gel with nanotape‐like morphology. This study demonstrates that self‐assembly of functional dyes can be judiciously manipulated by an external stimulus and can be further controlled by the addition of carbon nanotubes.
ChemInform Abstract: Homologous Series of Rare‐Earth Zinc Arsenides REZn2‐xAs2·n(REAs) (RE: La—Nd, Sm; n = 3, 4, 5, 6).
Authors: Lin Xinsong , Mar Arthur 
Published: August 2013

AbstractThe title compounds and quaternary derivatives in which Mn partially substitutes for Zn are prepared from stoichiometric mixtures of the elements (silica tubes, 500 °C for 2 d and 750 °C for 7 d).
ChemInform Abstract: Synthesis and Visible‐Light Photochromism of a New Composite Based on Polymolybdate Enclosed in Magadiite.
Authors: Chen Yufeng , Yu Gensheng , Li Fei 
Published: August 2013

AbstractA composite of composition H2.0Si13.9O28.8/ [(NBu4)1.8H2.2· (Mo8O26)]0.2·2.7H2O is synthesized by an exfoliation/self‐assembly process by dissolving sodium molybdate in a colloidal suspension of protonated magadiite in aqueous (Bu4N)OH solution.
ChemInform Abstract: Phase Formation in the Li2MoO4—Rb2MoO4 —Fe2(MoO4)3 System and Crystal Structure of a Novel Triple Molybdate LiRb2Fe(MoO4)3.
Authors: Khal'baeva Klara M. , Solodovnikov Sergey F. , Khaikina Elena G. , Kadyrova Yuliya M. , Solodovnikova Zoya A. , Basovich Olga M. 
Published: August 2013

AbstractX‐ray investigation of solid state interaction of the components in the Li2MoO4—Rb2MoO4 —Fe2(MoO4)3 system is carried out, and a subsolidus phase diagram of the system is constructed.
ChemInform Abstract: Hydrothermal Synthesis and Structural Analysis of New Mixed Oxyanion Borates: Ba11B26O44(PO4)2 (OH)6, Li9BaB15O27(CO3) and Ba3Si2B6O16.
Authors: Heyward Carla , McMillen Colin D. , Kolis Joseph 
Published: August 2013

AbstractBa11B26O44(PO4)2 (OH)6 (I) is prepared in low yield by hydrothermal reaction of Ba(OH)2, (NH4)2B10O16, and BaHPO4 in aq.
ChemInform Abstract: β‐K(VO2)2(PO4).
Authors: Yahmed Safa Ezzine , Ayed Meriem , Zid Mohamed Faouzi , Driss Ahmed 
Published: August 2013

AbstractThe title compound, a new form of divanadium phosphate KV2PO8, is prepared by reaction of a 3:3:2 mixture of KNO3, NH4VO3, and NH4H2PO4 (1.
ChemInform Abstract: Hexafluoridotechnetate(IV) Revisited.
Authors: Balasekaran Samundeeswari Mariappan , Molski Matthias , Spandl Johann , Hagenbach Adelheid , Alberto Roger , Abram Ulrich 
Published: August 2013

AbstractNew and improved syntheses for [TcF6]2‐ salts and single crystal structures for (VI) and (VIII) are reported.
ChemInform Abstract: A New Inorganic 2D Network Polyoxometalate Constructed from Wells—Dawson Phosphomolybdate Linked Through Cu(II) Ions.
Authors: Li Lu , Ma Pengtao , Wang Jingping , Niu Jingyang 
Published: August 2013

AbstractDark green crystals of [Cu(H2O)4]3 [P2Mo18O62]·12H2O are synthesized from aqueous solutions containing CuCl2, Na2MoO4, H2O2, H3PO4, and HClO4 (room temperature, 27% yield).
ChemInform Abstract: From a Remarkable Manifestation of Polar Effects in a Radical Fragmentation to the Convergent Synthesis of Highly Functionalized Ketones.
Authors: Debien Laurent , Zard Samir Z. 
Published: August 2013

AbstractUnprotected vinyl carbinols react with the radicals generated from xanthanes involving a rare cleavage of a C—C bond in a non‐strained open chain structure.
ChemInform Abstract: Heterogeneous Transfer Hydrogenation over Mesoporous SBA‐15 Co‐Modified by Anionic Sulfonate and Cationic Ru(III) Complex.
Authors: Chen Sheng‐Jie , You Hong‐Xing , Vo‐Thanh Giang , Liu Ye 
Published: August 2013

AbstractA new immobilized transfer hydrogenation catalyst is developed and characterized.
ChemInform Abstract: Palladium‐Catalyzed Bond Reorganization of 1,3‐Diynes: An Entry to Diverse Functionalized 1,5‐Dien‐3‐ynes.
Authors: Wu Wanqing , Gao Yang , Jiang Huanfeng , Huang Yubing 
Published: August 2013

AbstractThis method can also be used for the introduction of other acyl groups or bromine by replacing Ac2O/HOAc or LiCl with the appropriate reagents.
ChemInform Abstract: A Novel Ireland—Claisen Rearrangement/Diels—Alder Tandem Reaction of Propargylic Acrylates with Acyclic Dienophiles.
Authors: Li Yun‐Xia , Sheng Yi‐Lin , Zhang Bi‐Song 
Published: August 2013

AbstractThe sequence allows the synthesis of cyclic α,β‐unsaturated carboxylic acids with complete regioselectivity.
ChemInform Abstract: N′‐[4‐[(Substituted imino)methyl]benzylidene]‐substituted Benzohydrazides: Synthesis, Antimicrobial, Antiviral, and Anticancer Evaluation, and QSAR Studies.
Authors: Kumar Pradeep , Narasimhan Balasubramanian , Ramasamy Kalavathy , Mani Vasudevan , Mishra Rakesh Kumar , Abdul Majeed Abu Bakar , De Clercq Erik 
Published: August 2013

AbstractExtensive QSAR studies of newly synthesized title compounds reveal that (VIIIa) and (VIIIb) are the most potent antimicrobial agents.
ChemInform Abstract: Enantioselective Additions of (Trifluoromethyl)trimethylsilane to α‐Imino Ketones Derived from Aryl Glyoxals.
Authors: Obijalska Emilia , Mloston Grzegorz , Six Alice 
Published: August 2013

AbstractAddition of silane (II) to α‐imino ketones in the presence of a cinchona‐based catalyst provides O‐silylated β‐imino alcohols.
ChemInform Abstract: Carbon—Carbon Bond Construction Using Boronic Acids and Aryl Methyl Sulfides: Orthogonal Reactivity in Suzuki‐Type Couplings.
Authors: Hooper Joel F. , Young Rowan D. , Pernik Indrek , Weller Andrew S. , Willis Michael C. 
Published: August 2013

AbstractA novel ruthenium catalyzed cross‐coupling reaction between the title substrates, which shows good functional group tolerance, is developed.
ChemInform Abstract: Synthesis of Chiral N‐Sulfonyl and N‐Phosphinoyl α‐Halo Aldimine Precursors.
Authors: Stanton Gretchen R. , Goellue Mehmet , Platoff Rebecca M. , Rich Corinne E. , Carroll Patrick J. , Walsh Patrick J. 
Published: August 2013

AbstractSynthesis of the chiral and racemic N‐sulfonyl‐α‐halo aldimine precursors and N‐phosphinoyl‐α‐chloro aldimine adducts is developed.
ChemInform Abstract: Retention or Inversion in Stereospecific Nickel‐Catalyzed Cross‐Coupling of Benzylic Carbamates with Arylboronic Esters: Control of Absolute Stereochemistry with an Achiral Catalyst.
Authors: Harris Michael R. , Hanna Luke E. , Greene Margaret A. , Moore Curtis E. , Jarvo Elizabeth R. 
Published: August 2013

AbstractA Ni‐catalyzed Suzuki‐Miyaura cross‐coupling reaction for the synthesis of enantioenriched triarylmethanes is developed.
ChemInform Abstract: Nickel‐Catalyzed Cross‐Couplings of Benzylic Pivalates with Arylboroxines: Stereospecific Formation of Diarylalkanes and Triarylmethanes.
Authors: Zhou Qi , Srinivas Harathi D. , Dasgupta Srimoyee , Watson Mary P. 
Published: August 2013

AbstractThe title reaction has broad scope with respect to the arylboroxine and benzylic pivalate, enabling the synthesis of a variety of diarylalkanes and triarylmethanes in good yields and enantioselectivities.
ChemInform Abstract: Palladacycle‐Catalyzed Decarboxylative Coupling of Alkynyl Carboxylic Acids with Aryl Chlorides under Air.
Authors: Li Xiang , Yang Fan , Wu Yangjie 
Published: August 2013

AbstractThis method is suitable for a broad variety of aryl chlorides including electron‐poor, ‐neutral and ‐rich and even sterically hindered substrates.
ChemInform Abstract: Successive C—C Coupling of Dienes to Vicinally Dioxygenated Hydrocarbons: Ruthenium Catalyzed [4 + 2] Cycloaddition Across the Diol, Hydroxycarbonyl, or Dione Oxidation Levels.
Authors: Geary Laina M. , Glasspoole Ben W. , Kim Mary M. , Krische Michael J. 
Published: August 2013

AbstractThe products can be obtained from diols, hydroxyketones [cf.
ChemInform Abstract: Metal‐Mediated Reactions of Aryl Isocyanates with Dimethoxycarbene to Form Isatin Derivatives.
Authors: Rigby James H. , Brouet Stephanie A. 
Published: August 2013

AbstractConditions which involve Cu(II) catalysis are developed to control the reaction of aryl isocyanates or analogous benzoyl azides with dimethoxycarbene for the formation of isatin derivatives.
ChemInform Abstract: Nitrogen‐Containing Lewis Bases Catalyzed Highly Regio‐ and Stereoselective Reactions of Allenyl Acetates with Isatin‐Derived Oximes.
Authors: Yang Yuan‐Liang , Wei Yin , Xu Qin , Shi Min 
Published: August 2013

AbstractThe title reaction shows a distinct dependence on both catalyst and solvent.
ChemInform Abstract: Synthetic Route to Chiral Indolines via Ring‐Opening/C—N Cyclization of Activated 2‐Haloarylaziridines.
Authors: Ghorai Manas K. , Nanaji Y. 
Published: August 2013

AbstractA simple and practical approach for the title synthesis of racemic and non‐racemic 3‐substituted indolines via regio‐ and stereoselective SN2‐type ring‐opening of activated 2‐haloarylaziridines (I) and (V) is reported.