bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary decompressive craniectomy in patients with large intracerebral hematomas due to aneurysmal subarachnoid hemorrhage
Authors: Wenz Fabian , Ziebart Andreas , Hackenberg Katharina A. M. , Rinkel Gabriel J. E. , Etminan Nima , Abdulazim Amr 
Published: August 2024

Abstract

Background
Decompressive craniectomy (DC) can alleviate increased intracranial pressure in aneurysmal subarachnoid hemorrhage patients with concomitant space-occupying intracerebral hemorrhage, but also carries a high risk for complications. We studied outcomes and complications of DC at time of ruptured aneurysm repair.

Methods
Of 47 patients treated between 2010 and 2020, 30 underwent DC during aneurysm repair and hematoma evacuation and 17 did not. We calculated odds ratios (OR) for delayed cerebral ischemia (DCI), angiographic vasospasm, DCI-related infarction, and unfavorable functional outcome (extended Glasgow Outcome Scale 1–5) at three months. Complication rates after DC and cranioplasty in the aneurysmal subarachnoid hemorrhage patients were compared to those of all 107 patients undergoing DC for malignant cerebral infarction during the same period.

Results
In DC versus no DC patients, proportions were for clinical DCI 37% versus 53% (OR = 0.5;95%CI:0.2–1.8), angiographic vasospasm 37% versus 47% (OR = 0.7;95%CI:0.2–2.2), DCI-related infarctions 17% versus 47% (OR = 0.2;95%CI:0.1–0.7) and unfavorable outcome 80% versus 88% (OR = 0.5;95%CI:0.1–3.0). ORs were similar after adjustment for baseline predictors for outcome. Complications related to DC and cranioplasty occurred in 18 (51%) of subarachnoid hemorrhage patients and 41 (38%) of cerebral infarction patients (OR = 1.7;95%CI:0.8–3.7).

Conclusions
In patients with aneurysmal subarachnoid hemorrhage and concomitant space-occupying intracerebral hemorrhage, early DC was not associated with improved functional outcomes, but with a reduced rate of DCI-related infarctions. This potential benefit has to be weighed against high complication rates of DC in subarachnoid hemorrhage patients.
Expression of microRNA-223 and microRNA-214 in gingival crevicular fluid of smoker and nonsmoker periodontitis patients, an observational diagnostic accuracy study
Authors: AbdelKawy Maha , Tarrad Nayroz Abdel Fattah , Shaker Olfat Gamil , Hassan Sandy 
Published: August 2024

Abstract
Objective
Periodontitis is a multifactorial disease that affects a wide range of populations. However, its pathogenesis remains unclear. miRNAs are now considered potential diagnostic markers for many inflammatory diseases. Thus, the aim of this study was to assess the expression of microRNA-223(miRNA-223) and microRNA-214 (miRNA-214) in gingival crevicular fluid (GCF) of smoker and nonsmoker with periodontitis.

Materials and methods
We conducted a prospective study among 42 participants: 14 healthy controls, 14 nonsmoker periodontitis participants, and 14 smokers with periodontitis. Eligibility criteria for inclusion were consecutive adults, aged 20–60 years, with stage III periodontitis grade B/C and no systemic diseases. All consenting participants had gingival crevicular fluid samples collected after diagnosis to assess miRNA-214 and -223 by quantitative real-time polymerase chain reaction assay.

Results
ROC curve analyses for the non-smoker periodontitis group showed that miR-214 as a predictor in comparison to miR-223 had higher sensitivity [92.86%-64.29%], same specificity [100%], and a significantly higher area under the curve [0.974–0.796] respectively (p = 0.036). As for the smoker periodontitis group, a ROC curve with miR-214 as predictor in comparison to miR-223 had higher sensitivity [100%-71.43%], same specificity [100%], and a non-significantly higher area under the curve [1–0.872], respectively (p = 0.059).

Conclusion
Both miRNA-214 and 223 are reliable potential diagnostic markers for periodontitis, with miRNA-214 being more accurate for smokers with periodontitis.

Clinical relevance
Both miRNA-214 and 223 could be considered for potential chair-side diagnostics, by simply collecting GCF detecting the disease in its first steps and aid in preventing unrepairable damage.
Temporal patterns in adolescent psychiatric treatment and outcomes: a nationwide register-based cohort follow-up
Authors: Bergström Tomi , Valtanen Kari , Miettunen Jouko , Gauffin Tapio , Kurtti Mia 
Published: August 2024

AbstractThe rise in mental health problems among adolescents in high-income countries presents a challenge to service systems. For the development of services, there is a need for better insight into temporal psychiatric treatment-trends and outcomes. This study aims to analyze time-trends in both psychiatric treatment patterns and outcomes, utilizing a national sample of all adolescents receiving psychiatric treatment in Finland from 2003 to 2013. For time-trend-analysis, the sample was divided into two cohorts, using the onset year of 2008 as a cutoff. For each case, information on psychiatric treatment was gathered from registers within a five-year follow-up period from the onset of treatment or to death. The association between the inclusion year and outcome variables was studied via weighted generalized linear models. Adolescents in the latter cohort had a greater proportion (p < 0.001) of mood and anxiety diagnoses, a lower likelihood of hospitalization, a higher average of outpatient visits, and greater usage of psychotropics (excluding benzodiazepines). Those whose treatment began after 2008 were more likely to be alive (baseline characteristic adjusted Odds Ratio (aOR): 0.7, 95%CI: 0.6–0.8) and still in treatment contact (aOR: 1.4, 95%CI: 1.3–1.4) after four years from the onset. There was no difference in the long-term disability ratio. The results indicate favorable developments towards outpatient care in mental health services for adolescents with a significant decrease in mortality. Approaches to further developing cost-effective, personalized mental health services are discussed.
Does kinship with the silverback matter? Intragroup social relationships of immature wild western lowland gorillas after social upheaval
Authors: Tamura Masaya , Akomo-Okoue Etienne François , Mangama-Koumba Lilian Brice , Wilfried Ebang Ella Ghislain , Mindonga-Nguelet Fred Loïc 
Published: August 2024

AbstractIn primates living in one-male groups, the sole resident male is often an important social partner for group immatures. For such groups, however, replacement of the male and subsequent disruptions of their relationships are almost inevitable. Here, we described social relationships of immature wild western lowland gorillas within a habituated group, where two natal and eight immigrant immatures lived with the resident silverback. We recorded 5 m proximities among group members as an indicator of social closeness. We found that natal immatures spent more time within 5 m of the silverback than immigrant ones. The social closeness between the silverback and the younger immigrant immatures sharply increased after 1 year, but these values were still below those of the natal immatures. Regarding the development of independence from the mother, we found no significant difference between natal and immigrant immatures. The socially preferred nonmother mature for natal immatures was the silverback, whereas many immigrant immatures preferred a paternal adult sister who had previously co-resided with them in a previous group. Our results suggest that familiarity may be an important determinant of the social closeness between the silverback and immatures, but 1 year of co-residence might be too short to construct sufficient familiarity. The paternal sister may have played a pivotal role in the assimilation of immigrant immatures into the non-natal group. Nonetheless, it is not negligible that the silverback and immigrant immatures formed day-to-day close proximities. His tolerance toward co-residence with immigrant immatures can be considered a reproductive tactic.
Towards assessing and improving the reliability of ultrashort echo time quantitative magnetization transfer (UTE-qMT) MRI of cortical bone: In silico and ex vivo study
Authors: Shin Soo Hyun , Moazamian Dina , Tang Qingbo , Jerban Saeed , Ma Yajun , Du Jiang , Chang Eric Y. 
Published: August 2024

Abstract
Objective
To assess and improve the reliability of the ultrashort echo time quantitative magnetization transfer (UTE-qMT) modeling of the cortical bone.

Materials and Methods
Simulation-based digital phantoms were created that mimic the UTE-qMT properties of cortical bones. A wide range of SNR from 25 to 200 was simulated by adding different levels of noise to the synthesized MT-weighted images to assess the effect of SNR on UTE-qMT fitting results. Tensor-based denoising algorithm was applied to improve the fitting results. These results from digital phantom studies were validated via ex vivo rat leg bone scans.

Results
The selection of initial points for nonlinear fitting and the number of data points tested for qMT analysis have minimal effect on the fitting result. Magnetization exchange rate measurements are highly dependent on the SNR of raw images, which can be substantially improved with an appropriate denoising algorithm that gives similar fitting results from the raw images with an 8-fold higher SNR.

Discussion
The digital phantom approach enables the assessment of the reliability of bone UTE-qMT fitting by providing the known ground truth. These findings can be utilized for optimizing the data acquisition and analysis pipeline for UTE-qMT imaging of cortical bones.
Modeling properties of chromosome territories using polymer filaments in diverse confinement geometries
Authors: Nahali Negar , Oshaghi Mohammadsaleh , Paulsen Jonas 
Published: August 2024

AbstractInterphase chromosomes reside within distinct nuclear regions known as chromosome territories (CTs). Recent observations from Hi-C analyses, a method mapping chromosomal interactions, have revealed varied decay in contact probabilities among different chromosomes. Our study explores the relationship between this contact decay and the particular shapes of the chromosome territories they occupy. For this, we employed molecular dynamics (MD) simulations to examine how confined polymers, resembling chromosomes, behave within different confinement geometries similar to chromosome territory boundaries. Our simulations unveil so far unreported relationships between contact probabilities and end-to-end distances varying based on different confinement geometries. These findings highlight the crucial impact of chromosome territories on shaping the larger-scale properties of 3D genome organization. They emphasize the intrinsic connection between the shapes of these territories and the contact behaviors exhibited by chromosomes. Understanding these correlations is key to accurately interpret Hi-C and microscopy data, and offers vital insights into the foundational principles governing genomic organization.
Correlates of Tobacco Use Among People with Mental Illness Within Asia: A Scoping Review
Authors: Parul Parul , Joseph Bindu , Datta Sunil , Rahman Muhammad Aziz 
Published: August 2024

AbstractTobacco use among people with mental illness is one of the contributing risk factors for premature morbidity and mortality. Two in three people with mental illness are current smokers with deteriorating physical health and quality of life. This review outlines the prevalence and predictors of tobacco use among people with mental illness in Asia. Twenty-five cross-sectional studies were selected from the exhaustive search of databases. Ten countries emerged based on the number of studies conducted within Asia among people diagnosed with mental illness and tobacco use, namely, India (8), China (7), Pakistan (2), Singapore (2), Sri Lanka (01), Japan (01), Jordan (01), Malaysia (01), Korea (01), and Taiwan (01). The prevalence of tobacco use was in the range of 3.6% to 89.4%, with the measure of precision at 95% confidence. The highest and lowest prevalence was reported in China, followed by India. Being male, separated, lower education, unemployed, lack of family support, a psychotic diagnosis, lack of knowledge, motivation, and a coping mechanism were predictors of tobacco use. This review emphasized the extent and predictors of tobacco use among this vulnerable group that need to be reflected while initiating and implementing cessation strategies by healthcare providers.
Guidelines for using financial incentives in software-engineering experimentation
Authors: Krüger Jacob , Çalıklı Gül , Bershadskyy Dmitri , Otto Siegmar , Zabel Sarah , Heyer Robert 
Published: August 2024

Abstract
Context:
Empirical studies with human participants (e.g., controlled experiments) are established methods in Software Engineering (SE) research to understand developers’ activities or the pros and cons of a technique, tool, or practice. Various guidelines and recommendations on designing and conducting different types of empirical studies in SE exist. However, the use of financial incentives (i.e., paying participants to compensate for their effort and improve the validity of a study) is rarely mentioned

Objective:
In this article, we analyze and discuss the use of financial incentives for human-oriented SE experimentation to derive corresponding guidelines and recommendations for researchers. Specifically, we propose how to extend the current state-of-the-art and provide a better understanding of when and how to incentivize.

Method:
We captured the state-of-the-art in SE by performing a Systematic Literature Review (SLR) involving 105 publications from six conferences and five journals published in 2020 and 2021. Then, we conducted an interdisciplinary analysis based on guidelines from experimental economics and behavioral psychology, two disciplines that research and use financial incentives.

Results:
Our results show that financial incentives are sparsely used in SE experimentation, mostly as completion fees. Especially performance-based and task-related financial incentives (i.e., payoff functions) are not used, even though we identified studies for which the validity may benefit from tailored payoff functions. To tackle this issue, we contribute an overview of how experiments in SE may benefit from financial incentivisation, a guideline for deciding on their use, and 11 recommendations on how to design them.

Conclusions:
We hope that our contributions get incorporated into standards (e.g., the ACM SIGSOFT Empirical Standards), helping researchers understand whether the use of financial incentives is useful for their experiments and how to define a suitable incentivisation strategy.
Identifying Correlates of Demanding and Responsive Features in Helicopter and Overprotective Parenting
Authors: Ryan Katherine M. , Zimmer-Gembeck Melanie J. , Speechley Molly , Stuart Jaimee , Soenens Bart , Zimmermann Grégoire , Van Petegem Stijn 
Published: August 2024

AbstractThe terms helicopter and overprotective parenting (HP, OP) have been used interchangeably, but there could be unexamined differences, including differences in correlations with other aspects of parenting and social-contextual conditions. In this study, we explored the factor structure of two commonly used measures of HP and OP in a sample of 701 Australian parents of adolescents (aged 16 – 19 years) and compared the correlations of the emergent factors with measures of parenting behaviors, mental health, and parenting pressures. Two factors were found that differentiated 13 items that referred to generally controlling and demanding OP behaviors (Demanding OP) from 8 items that referred to parenting under conditions of child difficulty suggesting a response to the child needs (Responsive OP). Before adjustment (i.e., zero-order correlations), but especially after adjusting for scores on the other factor (i.e., partial correlations), Demanding OP was associated with less positive (e.g., autonomy support) and more negative (e.g., control) parenting behaviors, as well as higher scores on parent anxiety, child anxiety and antisocial behavior, parental burnout, social comparison to parents on social media, and job/financial pressures. After adjustment for Demanding OP, Responsive OP aligned with positive parenting and more enjoyment of parenting, but was not associated with burnout or parent anxiety, and had little association with child mental health. Yet, Responsive OP was associated with more pressure to be an ideal parent. Both Demanding and Responsive OP were associated with more overvaluation of the child.
Intraoperative zero-heat-flux thermometry overestimates nasopharyngeal temperature by 0.39 °C: an observational study in patients undergoing congenital heart surgery
Authors: Brandes Ivo F. , Tirilomis Theodor , Nemeth Marcus , Wieditz Johannes , Bräuer Anselm 
Published: August 2024

Abstract
During surgery for congenital heart disease (CHD) temperature management is crucial. Vesical (Tves) and nasopharyngeal (TNPH) temperature are usually measured. Whereas Tves slowly responds to temperature changes, TNPH carries the risk of bleeding. The zero-heat-flux (ZHF) temperature monitoring systems SpotOn™ (TSpotOn), and Tcore™ (Tcore) measure temperature non-invasively. We evaluated accuracy and precision of the non-invasive devices, and of Tves compared to TNPH for estimating temperature. In this prospective observational study in pediatric and adult patients accuracy and precision of TSpotOn, Tcore, and Tves were analyzed using the Bland-Altman method. Proportion of differences (PoD) and Lin´s concordance correlation coefficient (LCC) were calculated. Data of 47 patients resulted in sets of matched measurements: 1073 for TSpotOn vs. TNPH, 874 for Tcore vs. TNPH, and 1102 for Tves vs. TNPH. Accuracy was − 0.39 °C for TSpotOn, -0.09 °C for Tcore, and 0.07 °C for Tves. Precisison was between − 1.12 and 0.35 °C for TSpotOn, -0.88 to 0.71 °C for Tcore, and − 1.90 to 2.05 °C for Tves. PoD ≤ 0.5 °C were 71% for TSpotOn, 71% for Tcore, and 60% for Tves. LCC was 0.9455 for TSpotOn, 0.9510 for Tcore, and 0.9322 for Tves. Temperatures below 25.2 °C (TSpotOn) or 27.1 (Tcore) could not be recorded non-invasively, but only with Tves. Trial registration German Clinical Trials Register, DRKS00010720.
Classification of Practical Floor Moisture Damage Using GPR - Limits and Opportunities
Authors: Klewe Tim , Strangfeld Christoph , Ritzer Tobias , Kruschwitz Sabine 
Published: August 2024

AbstractMachine learning in non-destructive testing (NDT) offers significant potential for efficient daily data analysis and uncovering previously unknown relationships in persistent problems. However, its successful application heavily depends on the availability of a diverse and well-labeled training dataset, which is often lacking, raising questions about the transferability of trained algorithms to new datasets. To examine this issue closely, the authors applied classifiers trained with laboratory Ground Penetrating Radar (GPR) data to categorize on-site moisture damage in layered building floors. The investigations were conducted at five different locations in Germany. For reference, cores were taken at each measurement point and labeled as (i) dry, (ii) with insulation damage, or (iii) with screed damage. Compared to the accuracies of 84 % to 90 % within the laboratory training data (504 B-Scans), the classifiers achieved a lower overall accuracy of 53 % for on-site data (72 B-Scans). This discrepancy is mainly attributable to a significantly higher dynamic of all signal features extracted from on-site measurements compared to laboratory training data. Nevertheless, this study highlights the promising sensitivity of GPR for identifying individual damage cases. In particular the results showing insulation damage, which cannot be detected by any other non-destructive method, revealed characteristic patterns. The accurate interpretation of such results still depends on trained personnel, whereby fully automated approaches would require a larger and diverse on-site data set. Until then, the findings of this work contribute to a more reliable analysis of moisture damage in building floors using GPR and offer practical insights into applying machine learning to non-destructive testing for civil engineering (NDT-CE).
TAM-associated CASQ1 mutants diminish intracellular Ca2+ content and interfere with regulation of SOCE
Authors: Gamberucci Alessandra , Nanni Claudio , Pierantozzi Enrico , Serano Matteo , Protasi Feliciano , Rossi Daniela , Sorrentino Vincenzo 
Published: August 2024

AbstractTubular aggregate myopathy (TAM) is a rare myopathy characterized by muscle weakness and myalgia. Muscle fibers from TAM patients show characteristic accumulation of membrane tubules that contain proteins from the sarcoplasmic reticulum (SR). Gain-of-function mutations in STIM1 and ORAI1, the key proteins participating in the Store-Operated Ca2+ Entry (SOCE) mechanism, were identified in patients with TAM. Recently, the CASQ1 gene was also found to be mutated in patients with TAM. CASQ1 is the main Ca2+ buffer of the SR and a negative regulator of SOCE. Previous characterization of CASQ1 mutants in non-muscle cells revealed that they display altered Ca2+dependent polymerization, reduced Ca2+storage capacity and alteration in SOCE inhibition. We thus aimed to assess how mutations in CASQ1 affect calcium regulation in skeletal muscles, where CASQ1 is naturally expressed. We thus expressed CASQ1 mutants in muscle fibers from Casq1 knockout mice, which provide a valuable model for studying the Ca2+ storage capacity of TAM-associated mutants. Moreover, since Casq1 knockout mice display a constitutively active SOCE, the effect of CASQ1 mutants on SOCE inhibition can be also properly examined in fibers from these mice. Analysis of intracellular Ca2+ confirmed that CASQ1 mutants have impaired ability to store Ca2+and lose their ability to inhibit skeletal muscle SOCE; this is in agreement with the evidence that alterations in Ca2+entry due to mutations in either STIM1, ORAI1 or CASQ1 represents a hallmark of TAM.
How nitrogen deposition hampers common juniper regeneration in heathlands
Authors: Veldhuis Erik R. , Verheyen Kris , Smolders Alfons J. P. , Smit Chris 
Published: August 2024

Abstract
Aims
Common Juniper (Juniper communis) populations in western Europe are rapidly declining due to a lack of regeneration, which has been linked to nitrogen (N) deposition. However, the mechanisms by which N deposition affects juniper are not clear. Nitrogen deposition can lead to N eutrophication and soil acidification, which cause nutrient leaching and metal mobilisation with potential negative impacts on juniper regeneration. We investigated associations among soil element concentration (soil [E]), needle element concentration (needle [E]) and plant performance in terms of height growth and viable seed production.

Methods
We sampled adult females and juveniles across 6 natural heathland areas in the Netherlands and Belgium, and applied linear mixed models for eleven elements to test associations among plant performance, soil [E], and needle [E].

Results
Soil [E] was reflected in needle [E], which subsequently was associated with juniper growth. However, direct associations between soil [E] and growth were absent. Seed viability was positively associated with soil Mg concentration, marginally with Ca and needle Ca and K concentrations, and negatively with soil NO3 and needle N, S and Zn concentrations. Generally seed viability, needle Ca and K concentrations were low. Soil Al/P ratio was a better predictor for needle P than soil P concentration indicating that Al inhibits P uptake.

Conclusion
We conclude that 1) N eutrophication reduces seed viability, but increases growth, 2) nutrient leaching reduces nutrient uptake, seed viability and subsequently growth, and 3) Al mobilisation reduces P uptake and indirectly growth. N deposition amplifies these mechanisms and therefore inhibits regeneration and survival of juniper populations in western Europe.