bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome Sequence of Luminous Piezophile Photobacterium phosphoreum ANT-2200
Authors: Zhang Sheng-Da , Barbe Valérie , Garel Marc , Zhang Wei-Jia , Chen Haitao , Santini Claire-Lise , Murat Dorothée , Jing Hongmei , Zhao Yuan , Lajus Aurélie , Martini Séverine , Pradel Nathalie , Tamburini Christian , Wu Long-Fei 
Published: April 2014

ABSTRACT

Bacteria of the genus
Photobacterium
thrive worldwide in oceans and show substantially varied lifestyles, including free-living, commensal, pathogenic, symbiotic, and piezophilic. Here, we present the genome sequence of a luminous, piezophilic
Photobacterium phosphoreum
strain, ANT-2200, isolated from a water column at 2,200 m depth in the Mediterranean Sea. It is the first genomic sequence of the
P. phosphoreum
group. An analysis of the sequence provides insight into the adaptation of bacteria to the deep-sea habitat.
Genome Sequence of Fusarium graminearum Isolate CS3005
Authors: Gardiner Donald M. , Stiller Jiri , Kazan Kemal 
Published: April 2014

ABSTRACT

Fusarium graminearum
is one of the most important fungal pathogens of wheat, barley, and maize worldwide. This announcement reports the genome sequence of a highly virulent Australian isolate of this species to supplement the existing genome of the North American
F. graminearum
isolate Ph1.
Draft Genome Sequence of Methicillin-Resistant Staphylococcus aureus CUHK_188 (ST188), a Health Care-Associated Bacteremic Isolate from Hong Kong
Authors: Ip Margaret , Wang Zheng , Lam Wai Yip , Zhou Haokui , Tsui Stephen 
Published: April 2014

ABSTRACT

We report the draft genome sequence of a methicillin-resistant
Staphylococcus aureus
strain designated CUHK_188, isolated from a bacteremic patient undergoing treatment at a university teaching hospital in Hong Kong. This strain belongs to sequence type 188 (ST188), with
spa
type t189 and staphylococcal cassette chromosome
mec
type V.
Complete Genome Sequence of Porcine Coronavirus HKU15 Strain IN2847 from the United States
Authors: Wang Leyi , Zhang Yan , Byrum Beverly 
Published: April 2014

ABSTRACT
Porcine coronavirus HKU15 (PorCoV HKU15) was first detected in pigs with clinical diseases in February 2014 in the United States. Here, we report the complete genome sequence of Indiana strain IN2847, which might be useful for understanding the molecular profile of PorCoV HKU15.
Iteradensovirus from the Monarch Butterfly,
Danaus plexippus plexippus
Authors: Yu Qian , Tijssen Peter 
Published: April 2014

ABSTRACT

The 5,006-nucleotide (nt)-long genome of a new virus from monarch butterfly pupae was cloned and sequenced. It was flanked by inverted terminal repeats (ITRs) of 239 nt with 163-nt hairpins. The monosense genome with three open reading frames is typical of the genus
Iteradensovirus
in the subfamily
Densovirinae
of the family
Parvoviridae
.
Genome Sequence of Bacillus pumilus MTCC B6033
Authors: Villanueva Jacylyn , Switala Jack , Ivancich Anabella , Loewen Peter C. 
Published: April 2014

ABSTRACT

Bacillus pumilus
is a Gram-positive, rod-shaped, aerobic bacterium isolated from the soil.
B. pumilus
strain B6033 was originally selected as a biocatalyst for the stereospecific oxidation of β-lactams. Here, we present a 3.8-Mb assembly of its genome, which is the second fully assembled genome of a
B. pumilus
strain.
Chronic kidney disease as a risk factor for acute community-acquired infections in high-income countries: a systematic review
Authors: McDonald Helen I , Thomas Sara L , Nitsch Dorothea 
Published: April 2014

ObjectiveA systematic review of the association of predialysis chronic kidney disease (CKD) with the incidence of acute, community-acquired infections.DesignWe searched the MEDLINE, EMBASE and Cochrane databases (inception to 16 January 2014) for studies analysing the association of predialysis kidney disease with the incidence of acute, community-acquired urinary tract infection (UTI), lower respiratory tract or central nervous system infections or sepsis. Studies were required to include at least 30 participants with and without kidney disease.Setting and participantsCommunity-based populations of adults in high-income countries.Outcome measuresAcute, community-acquired UTI, lower respiratory tract or central nervous system infections or sepsis.ResultsWe identified 14 eligible studies. Estimates from two studies lacked 95% CIs and SEs. The remaining 12 studies yielded 17 independent effect estimates. Only three studies included infections managed in the community. Quality assessment revealed that probable misclassification of kidney disease status and poor adjustment for confounding were common. There was evidence from a few large high-quality studies of a graded association between predialysis CKD stage and hospitalisation for infection. One study found an interaction with age, with a declining effect of CKD on infection risk as age increased. There was evidence of between-studies heterogeneity (I2=96.5%, p<0.001) which persisted in subgroup analysis, and thus meta-analysis was not performed.ConclusionsPredialysis kidney disease appears to be associated with increased risk of severe infection. Whether predialysis kidney disease increases the susceptibility to infections and whether age modifies this association remains unclear.
Youth tobacco access: trends and policy implications
Authors: Gendall Philip , Hoek Janet , Marsh Louise , Edwards Richard , Healey Benjamin 
Published: April 2014

ObjectiveWe examined whether the supply routes via which New Zealand adolescents aged 14–15 years accessed tobacco had changed during a period of dynamic policy activity.SettingWe analysed data from seven consecutive years (2006–2012) of the New Zealand Action on Smoking and Health (ASH) Year 10 survey, a nationwide cross-sectional annual survey.ParticipantsAll New Zealand schools teaching Year 10 students are invited to participate in the survey; school-level participation rates have ranged between 44% and 58% and more than 25 000 students have responded to the survey in each year. The results presented draw on the subsample who reported smoking when surveyed (N∼9200). The data were weighted by age, ethnicity and school socioeconomic status (SES) to remove effects of systematic over-response by New Zealand Europeans and under-response by those in lower SES groups from trend analyses.Primary and secondary outcome measuresThe survey measured adolescents’ main reported tobacco supply source.ResultsSmoking prevalence declined significantly (8.1%) over the period examined (linear tend coefficient: −0.74; 95% CI −1.03 to −0.45, significant p<0.01). Friends showed a significant decline in relative importance as a supply source while caregivers and other sources showed a significant increase over the period examined.ConclusionsThe findings show that social supply, particularly via friends, caregivers and others, such as older siblings, is a key tobacco source for adolescents; commercial supply is much less important. The findings raise questions about the additional measures needed to reduce smoking among youth. Endgame policies that make tobacco more difficult to obtain and less appealing and convenient to gift merit further investigation.
Effect of green tea supplementation on blood pressure among overweight and obese adults: a protocol for a systematic review
Authors: Li Guowei , Zhang Yuan , Mbuagbaw Lawrence , Holbrook Anne , Levine Mitchell A H , Thabane Lehana 
Published: April 2014

IntroductionEmerging randomised controlled trials (RCTs) exploring the effect of green tea (GT) supplementation or GT extract (GTE) on blood pressure (BP) among overweight and obese adults yielded inconclusive results. We aim to conduct a systematic review to summarise the evidence of RCTs until now, to clarify the efficacy of GT supplementation or GTE in BP in overweight and obese populations.Methods and analysisThe Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE and ClinicalTrials.gov will be searched to retrieve potential RCTs. Unpublished studies will be identified by searching the abstract books or websites of the three major conference proceedings: the International Society of Hypertension, the Nutrition & Health Conference and the World Congress of Nutrition and Health. A random-effects meta-analysis will be performed to pool the mean difference for the change in BP from baseline (ie, postintervention BP minus baseline BP) between intervention groups and placebo groups of the included studies, presenting the pooled results with 95% CIs. Subgroups analyses will be conducted according to different doses of GT or GTE, trial duration, geographic regions, overweight versus obese participants, and participants with versus without change in body weight after intervention. Sensitivity analysis will be performed by excluding studies classified as having a high risk of bias, applying a fixed-effects model, using the postintervention BP for analyses and excluding trials with non-study cointerventions.Ethics and disseminationThis systematic review will be published in a peer-reviewed journal. It will be disseminated electronically and in print. Summarising the RCT evidence to clarify the efficacy in BP among overweight and obese adults will aid in making the dietary recommendation of GT and improving the clinical management of hypertension.Trial registration numberPROSPERO CRD42014007273.
The frequency of diagnostic errors in outpatient care: estimations from three large observational studies involving US adult populations
Authors: Singh Hardeep , Meyer Ashley N D , Thomas Eric J 
Published: April 2014

BackgroundThe frequency of outpatient diagnostic errors is challenging to determine due to varying error definitions and the need to review data across multiple providers and care settings over time. We estimated the frequency of diagnostic errors in the US adult population by synthesising data from three previous studies of clinic-based populations that used conceptually similar definitions of diagnostic error.MethodsData sources included two previous studies that used electronic triggers, or algorithms, to detect unusual patterns of return visits after an initial primary care visit or lack of follow-up of abnormal clinical findings related to colorectal cancer, both suggestive of diagnostic errors. A third study examined consecutive cases of lung cancer. In all three studies, diagnostic errors were confirmed through chart review and defined as missed opportunities to make a timely or correct diagnosis based on available evidence. We extrapolated the frequency of diagnostic error obtained from our studies to the US adult population, using the primary care study to estimate rates of diagnostic error for acute conditions (and exacerbations of existing conditions) and the two cancer studies to conservatively estimate rates of missed diagnosis of colorectal and lung cancer (as proxies for other serious chronic conditions).ResultsCombining estimates from the three studies yielded a rate of outpatient diagnostic errors of 5.08%, or approximately 12 million US adults every year. Based upon previous work, we estimate that about half of these errors could potentially be harmful.ConclusionsOur population-based estimate suggests that diagnostic errors affect at least 1 in 20 US adults. This foundational evidence should encourage policymakers, healthcare organisations and researchers to start measuring and reducing diagnostic errors.
Adverse drug events and medication errors in Japanese paediatric inpatients: a retrospective cohort study
Authors: Sakuma Mio , Ida Hiroyuki , Nakamura Tsukasa , Ohta Yoshinori , Yamamoto Kaori , Seki Susumu , Hiroi Kayoko , Kikuchi Kiyoshi , Nakayama Kengo , Bates David W , Morimoto Takeshi 
Published: April 2014

ObjectivesKnowledge about the epidemiology of adverse drug events (ADEs) and medication errors in paediatric inpatients is limited outside Western countries. To improve paediatric patient safety worldwide, assessing local epidemiology is essential.DesignThe Japan Adverse Drug Events (JADE) Study was a cohort study.SettingPaediatric inpatients at two tertiary care teaching hospitals in Japan.Main outcome measuresADEs and medication errors identified by onsite review of all medical charts, incident reports and prescription queries by pharmacists. Two independent physicians reviewed all incidents and classified ADEs and medication errors, as well as their severity and preventability.ResultsWe enrolled 1189 admissions which included 12 691 patient-days during the study period, and identified 480 ADEs and 826 medication errors. The incidence of ADEs was 37.8 (95% CI 34.4 to 41.2) per 1000 patient-days and that of medication errors was 65.1 (95% CI 60.6 to 69.5) per 1000 patient-days. Among ADEs, 4%, 23% and 73% were fatal or life-threatening, serious and significant, respectively. Among the 480 ADEs, 36 (8%) were considered to be preventable which accounted for 4% of all medication errors, while 668 (81%) of all medication errors were judged to have the potential to cause harm to patients. The most common error stage for preventable ADEs was monitoring (78%) whereas 95% of potential ADEs occurred at the ordering stage.ConclusionsADEs and medication errors were common in paediatric inpatients in Japan, though the proportion of ADEs that were preventable was low. The ordering and monitoring stages appeared most important for improving safety.
Association of paternal IQ in early adulthood with offspring mortality and hospital admissions for injuries: a cohort study of 503 492 Swedish children
Authors: Jelenkovic Aline , Silventoinen Karri , Tynelius Per , Rasmussen Finn 
Published: April 2014

BackgroundHigher intelligence (IQ) has been related to a lower risk of mortality and hospital admissions for injuries, but little is known about the effect of parental IQ on offspring outcomes. We explored associations of paternal IQ with mortality and hospitalisations for injuries from all external causes in offspring.MethodsA cohort of 503 492 Swedish children under 5 years of age with information on paternal IQ was obtained by record linkage of national registers. HR with 95% CIs were estimated using Cox regression.ResultsThere was some evidence that paternal IQ was inversely associated with total and external-cause mortality in offspring, although the effects were modest and disappeared when controlling for parents’ socioeconomic position (SEP). The only robust gradient was found between paternal IQ and hospital admissions for injuries (HRper 1-SD increase in IQ0.93, 95% CI 0.92 to 0.94; p<0.001), which was slightly attenuated but retained statistical significance after adjustment for SEP (0.95, 95% CI 0.94 to 0.97; p<0.001).ConclusionsChildren to fathers with lower IQ may have an increased risk of injury by external causes. Messages on family safety and injury prevention might be tailored according to parental cognitive abilities.
Sediment provenance studies in hydrocarbon exploration and production: an introduction
Authors: Smyth Helen R. , Morton Andrew , Richardson Nicholas , Scott Robert A. 
Published: April 2014

Abstract
Sediment provenance studies concern the origin, composition, transportation and deposition of detritus, and are therefore an important part of understanding the links between basinal sedimentation, and hinterland tectonics and unroofing. Such studies can add value at many stages of hydrocarbon exploitation, from identifying regional-scale crustal affinities and sediment-dispersal patterns during the earliest stages of exploration to detailed correlation in producing reservoirs and understanding the impact of mineralogy on reservoir diagenesis.
This Special Publication records 20 of the papers given at the conference titled ‘Sediment Provenance Studies in Hydrocarbon Exploration and Production’ organized by the Petroleum Group of the Geological Society of London, and held in London from 5 to 7 December 2011. The observations drawn in this introductory section reflect the volume editors’ experience, presentations at the conference and papers within this volume.
Effects of Fenofibric Acid on Carotid Intima-Media Thickness in Patients With Mixed Dyslipidemia on Atorvastatin Therapy
Authors: Davidson Michael H. , Rosenson Robert S. , Maki Kevin C. , Nicholls Stephen J. , Ballantyne Christie M. , Mazzone Theodore , Carlson Dawn M. , Williams Laura A. , Kelly Maureen T. , Camp Heidi S. , Lele Aditya , Stolzenbach James C. 
Published: April 2014

Objective—
To assess whether adding a fibrate to statin therapy reduces residual cardiovascular risk associated with elevated triglycerides and low high-density lipoprotein cholesterol, The Evaluation of Choline Fenofibrate (ABT-335) on Carotid Intima-Media Thickness (cIMT) in Subjects with Type IIb Dyslipidemia with Residual Risk in Addition to Atorvastatin Therapy (FIRST) trial evaluated the effects of fenofibric acid (FA) treatment on cIMT in patients with mixed dyslipidemia on atorvastatin.

Approach and Results—

This multicenter, double-blind, placebo-controlled study was performed in patients with mixed dyslipidemia (fasting triglycerides, ≥150 mg/dL; high-density lipoprotein cholesterol, ≤45 [men] or 55 mg/dL [women]; low-density lipoprotein cholesterol, ≤100 mg/dL once and averaging ≤105 mg/dL) and a history of coronary heart disease or risk equivalent. Patients on background atorvastatin (continued on starting dose or titrated to 40 mg, if needed) were randomized to FA 135 mg or placebo. The primary end point was rate of change from baseline through week 104 of the mean posterior-wall cIMT, measured by ultrasound. In patients with controlled low-density lipoprotein cholesterol while on atorvastatin background therapy, rate of change in posterior-wall cIMT was similar with FA plus atorvastatin (−0.006 mm/y) versus atorvastatin monotherapy (0.000 mm/y;
P
=0.22). FA plus atorvastatin was favored (
P
<0.05) in 5 of 24 prespecified subgroups: age ≥60 years, history of coronary artery disease, cIMT >0.795 mm, triglycerides 170 to 235 mg/dL, and statin use at entry. Adverse events were consistent with the known safety profiles of both drugs; however, FA plus atorvastatin was associated with a greater incidence of renal-related adverse events compared with atorvastatin monotherapy (6.5% versus 0.9%).

Conclusions—
Compared with atorvastatin monotherapy, FA plus atorvastatin did not further decrease cIMT progression in high-risk patients with mixed dyslipidemia.
Transfer of Patients With ST-Elevation Myocardial Infarction for Primary Percutaneous Coronary Intervention
Authors: Lambert Laurie J. , Brown Kevin A. , Boothroyd Lucy J. , Segal Eli , Maire Sébastien , Kouz Simon , Ross Dave , Harvey Richard , Rinfret Stéphane , Xiao Yongling , Nasmith James , Bogaty Peter 
Published: April 2014

Background—
Interhospital transfer of patients with ST-elevation myocardial infarction (STEMI) for primary percutaneous coronary intervention (PPCI) is associated with longer delays to reperfusion, related in part to turnaround (“door in” to “door out,” or DIDO) time at the initial hospital. As part of a systematic, province-wide evaluation of STEMI care, we examined DIDO times and associations with patient, hospital, and process-of-care factors.

Methods and Results—

We performed medical chart review for STEMI patients transferred for PPCI during a 6-month period (October 1, 2008, through March 31, 2009) and linked these data to ambulance service databases. Two core laboratory cardiologists reviewed presenting ECGs to identify left bundle-branch block and, in the absence of left bundle-branch block, definite STEMI (according to both cardiologists) or an ambiguous reading. Median DIDO time was 51 minutes (25th to 75th percentile: 35–82 minutes); 14.1% of the 988 patients had a timely DIDO interval (≤30 minutes as recommended by guidelines). The data-to-decision delay was the major contributor to DIDO time. Female sex, more comorbidities, longer symptom duration, arrival by means other than ambulance, arrival at a hospital not exclusively transferring for PPCI, arrival at a center with a low STEMI volume, and an ambiguous ECG were independently associated with longer DIDO time. When turnaround was timely, 70% of patients received timely PPCI (door-to-device time ≤90 minutes) versus 14% if turnaround was not timely (
P
<0.0001).

Conclusions—
Benchmark DIDO times for STEMI patients transferred for PPCI were rarely achieved. Interventions aimed at facilitating the transfer decision, particularly in cases of ECGs that are difficult to interpret, are likely to have the best impact on reducing delay to reperfusion.
Function of Natural Internal Mammary–to–Coronary Artery Bypasses and Its Effect on Myocardial Ischemia
Authors: Stoller Michael , de Marchi Stefano F. , Seiler Christian 
Published: April 2014

Background—
The function of naturally existing internal mammary (IMA)–to–coronary artery bypasses and their quantitative effect on myocardial ischemia are unknown.

Methods and Results—

The primary end point of this study was collateral flow index (CFI) obtained during two 1-minute coronary artery balloon occlusions, the first with and the second without simultaneous distal IMA occlusion. The secondary study end point was the quantitatively determined intracoronary ECG ST-segment elevation. CFI is the ratio of simultaneously recorded mean coronary occlusive pressure divided by mean aortic pressure both subtracted by mean central venous pressure. A total of 180 pairs of CFI measurements were performed among 120 patients. With and without IMA occlusion, CFI was 0.110±0.074 and 0.096±0.072, respectively (
P
<0.0001). The difference of CFI obtained in the presence minus CFI obtained in the absence of IMA occlusion was highest and most consistently positive during left IMA with left anterior descending artery occlusion and during right IMA with right coronary artery occlusion (ipsilateral occlusions): 0.033±0.044 and 0.025±0.027, respectively. This CFI difference was absent during right IMA with left anterior descending artery occlusion and during left IMA with right coronary artery occlusion (contralateral occlusions): −0.007±0.034 and 0.001±0.023, respectively (
P
=0.0002 versus ipsilateral occlusions). The respective CFI differences during either IMA with left circumflex artery occlusion were inconsistently positive. Intracoronary ECG ST-segment elevations were significantly reduced during ipsilateral IMA occlusions but not during contralateral or left circumflex artery occlusions.

Conclusion—
There is a functional, ischemia-reducing extracardiac coronary artery supply via ipsilateral but not via contralateral natural IMA bypasses.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCTO1676207.