bluuebunny/crossref_metadata_2025_split huggingface dataset:
P-488 EFFECTS OF INTERNAL FACEPIECE PRESSURE SETTINGS TRIGGERING THE FAN OPERATION OF POWERED AIR PURIFYING RESPIRATORS (PART 2)—EFFECTS ON SUBJECTIVE SYMPTOMS
Authors: Tahara Sayaka , Kitamura Hiroko , Motokawa Yukako , Hayashi Hiroyuki , Hanaoka Saki , Noghchi Makoto , Horie Seichi , Kawanami Syoko 
Published: July 2024

Abstract

Introduction
Our previous study found that humidity within a facepiece affects the feeling of stuffiness when respiratory protective equipment is worn. It was suggested that using powered air-purifying respirators (PAPRs), which provide air within the facepiece, alleviates this stuffiness. The present study investigates the relationship between the pressure settings triggering the operation of PAPRs and subjective symptoms.

Methods
The study involved 12 healthy, non-smoking men. We prepared three types of PAPR (i.e, PAPR-A: a respirator with a pressure setting higher than that commercially adopted, PAPR-B: a respirator having a commercial setting, and PAPR-C: a respirator having no operational fan). To mitigate order effects and exercise-induced fatigue, participants were randomly assigned to six groups. Subjective symptoms during exercise were measured using the visual analogue scale (VAS). The study was approved by the Ethics Committee of UOEH.

Results
The mean VAS values for intra-facepiece stuffiness were 4.67 (PAPR-A), 4.75 (PAPR-B), and 6.58 (PAPR-C). Significant differences were observed in the feeling of stuffiness within the facepiece between PAPR-A and PAPR-C and between PAPR-B and PAPR-C but not between PAPR-A and PAPR-B. Similar results were obtained for other subjective symptoms, namely difficulty in breathing, hotness within the facepiece, and discomfort.

Discussion
Considering our other finding that the intra-facepiece carbon dioxide concentration improved with enhanced ventilation, the observed improvements in subjective symptoms are also attributed to this enhancement. The improvement in subjective symptoms is thought to contribute to workers’ willingness to wear appropriate protective equipment.

Conclusion
Increasing the internal facepiece pressure setting of the PAPR improved subjective symptoms.
P-490 BLOOD MONOCYTE SUBPOPULATIONS AND CYTOKINES AS PREDICTORS OF OCCUPATIONAL CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITHIN THE NEXT THREE YEARS IN WORKERS EXPOSED TO AEROSOLS CONTAINING NANOPARTICLES
Authors: Shpagina Lyubov , Zenkova Marina , Shpagin lya , Logashenko Evgeniya , Nikolaev Anatoliy Saprykin , Kotova Olga , Nikolaev Alfiya Tsygankova , Kamneva Natalya , Anikina Ekaterina , Likhenko-Logvinenko Kristina 
Published: July 2024

Abstract

Introduction
There is unmet need in novel predictors of occupational chronic obstructive pulmonary disease (COPD) for risk management improvement. The aim of the study was to investigate the inflammatory factors associated with exposure of nanoparticles – the less investigated industrial aerosols’ component, and reveal potential risk markers.

Methods
It was a prospective observational study. Nanoparticles at workplaces air in a machine manufacturing facility were investigated by scanning electron microscopy and inductively coupled plasma atomic emission spectrometry. Participants were 250 employees (97,2% males, 2,8% females aged 51 (46-55) years, healthy at the time of inclusion) worked at the investigated workplaces. Monocyte subpopulations was measured by flow cytometry, serum cytokines by ELISA. Spirography was done every 6 months for 36 months. COPD was diagnosed by GOLD criteria. Relationships were measured by Cox proportional hazard and linear regression.

Results
Silica nanoparticles were predominant, their mass concentration was 0.035 (0.028-0.042) µg/mL. It was 31 (12.8%) COPD cases during follow up. In multivariate analysis (OR, 95% CI) CD14DimCD16+ monocytes (2.45, 1.003–6.001), fibroblast growth factor-2 (FGF-2) (9.61, 2.081–44.399), soluble vascular cellular adhesion molecule-1 (sVCAM-1) (1.49, 1.243–1.939), amino-terminal propeptide of type-III procollagen (PIIINP) (1.3, 1.070–1.570), matrix metalloproteinase-9 (MMP-9) (1.23, 1.023–1.470) were associated with COPD development. All these molecules were associated with silica nanoparticles mass concentration (p&lt;0.010).

Discussion
Perspective COPD predictors were established. Further validation is needed to develop the prognostic scale.

Conclusion
Percent of non-classical monocytes, serum levels of FGF-2, sVCAM-1, PIIINP and MMP-9 are perspective predictors of COPD within the next three years in workers exposed to aerosols, containing silica nanoparticles.
P-496 CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND OCCUPATIONAL EXPOSURES: THE CASE OF MOROCCO
Authors: Wachami Nadia Al , Louerdi Mohamed , Iderdar Younes , Boumendil Karima , Bouchachi Fatima-Zahra , Arraji Maryem , Chahboune Mohamed 
Published: July 2024

Abstract

Introduction
Occupational exposures are an important cause of chronic obstructive pulmonary disease (COPD). This work aims to analyze the epidemiological evidence on the association between occupational exposures, the development and aggravation of COPD, with a particular focus on Morocco.

Methods
Scientific databases were searched for studies reporting data on COPD and workplace exposures.

Results
Data from the published literature show that occupational exposures play an important role in the development of COPD. Positive correlations have been established between occupational exposures and the prevalence and incidence of COPD. In addition, occupational exposures have a negative impact on COPD patients, resulting in increased frequency of respiratory symptoms and exacerbations, reduced spirometric parameters and impaired quality of life. In Morocco, the link between occupational exposure and COPD has not been sufficiently studied.

Discussion
A limited number of studies have suggested that construction workers and former miners are at high risk of developing COPD. No studies investigating the effect of occupational exposure to dusts, vapors, gasses and fumes on the health status of COPD patients in Morocco were found.

Conclusion
Occupational exposure is a potential risk factor in the development and aggravation of COPD. In Morocco, this link has not been sufficiently studied. Consequently, it is time for more in-depth studies aimed at identifying at-risk occupations, assessing the exposure-response relationship, and determining the exposure limits that should be retained to guide COPD prevention and management strategies nationwide.
P-499 ACCELERATED SILICOSIS IN A STONEMASON – HOW MANY CASES DO WE NEED TO LEARN THE LESSON?
Authors: Handra Claudia- Mariana 
Published: July 2024

Abstract
Stonemasons are at high risk of silicosis: they generally work on a contract basis, in small enterprises, with minimal protective measures and due to frequent changes in employers might skip the continuity of an occupational medicine surveillance.
We present a case of a 32 years old men, who was heavily exposed to natural stones (including granite) as stonemason for 9 years and was never refered to a specialized clinic of occupational medicine for the mandatory annual checkup. He start working since he was 16 years old in a small workshop. The main activities were cutting, griding and polishing natural stones without protective equipment and no aspiration system.
In 2016 he was admitted in a pulmonology clinic for dispnea, mialgia and arthralgia.. This diagnosis of tuberculosis was ruled out after several negative sputum results. Lung and mediastinium ganglia biopsies were performed and confirmed the presence of the silicotic nodules and extensive fibrosis.
He was treated with systemic corticoid for cough and dyspneea exacerbation, but the clinical status progressively deteriorate. In 2022, he had a spontaneous pneumothorax. In June 2023, due to the severe mixed ventilatory disfunction (FVC=26%, FEF1 =16% and FEF1/CV = 50.4%, TLC = 37%), DLCO=5.77 mmHg (16%) he was proposed for the pulmonary transplant.
This case highlights the need for prevention in small enterprises and the desastrous consequences of ignoring the exposure. This message has to pass to employees and employers, authorities and all the ones involved in occupational risk management in order to stop cases like this one to happen.
O-334 MEASURING FRENCH FARMERS’ EXPOSURE TO FUNGICIDES DURING THE SOWING OF COATED SEEDS OF CORN AND STRAW CEREALS (WHEAT AND BARLEY)
Authors: Le Goff Jérémie , Lecluse Yannick , Pompili Juliette , Dupont Marie-Pierre , Hellec-Magny Pascale , Jarriges Jean , Bouchart Valérie , Lanson Justine , Boulanger Mathilde , Baldi Isabelle , Lebailly Pierre 
Published: July 2024

Abstract

Introduction
Occupational use of pesticides is responsible for health effects and improvement of prevention needs to better define exposing tasks and associated exposure levels. In agriculture, exposure during the handling of pesticide-coated seeds is unknown.

Methods
35 volunteer farmers were monitored during the sowing of coated cereals. Fludioxonil and prothioconazole fungicides were quantified by HPLC MS/MS in patches representing 11 body zones, placed under and over the clothing, in order to estimate potential and actual dermal exposure. XAD-2 filter was added for the respiratory route.

Results
90% of measurements were over the limit of quantification (&gt; 0,015 µg) and revealed large interindividual variations. Dermal exposure levels were higher at preparation of the seeder than after sowing in the field. During preparation of corn sowing, wearing gloves decreased exposure, while rolling empty seeds bags on the thighs increased it. For straw cereals, the filling time, emptying or adjustment of the seeder increased dermal exposure too. In the field, strongest exposures concerned operators who regularly got off of the tractor and/or kept the cabin closed. Respiratory route was generally far lower.

Discussion
For the first time, a low but systematic dermal exposure during sowing is highlighted. Measured levels remain below other activities such as pesticide application. However, as sowing is repeated over a season time, cumulative exposures have to be more considered.

Conclusion
Contrary to what is generally accepted, sowing with coated seeds exposes operators to pesticides. First identified determinants would be good levers for prevention.
P-510 GENOTOXICITY OF OCCUPATIONAL PESTICIDE EXPOSURES AMONG AGRICULTURAL WORKERS IN ARAB COUNTRIES
Authors: Sherif Moustafa , Makame Khadija , Östlundh Linda , Paulo Marilia Silva , Nemmar Abderrahim , Ali Bassam , Al-Rifai Rami , Nagy Károly , Ádám Balázs 
Published: July 2024

Abstract

Introduction
Exposure to pesticides in Arab countries poses a significant public health concern, given the extensive agricultural activity and pesticide utilization.

Methods
This systematic review and meta-analysis study aims to assess the genotoxic effects of agricultural pesticide exposure on adult agricultural workers in 19 Middle Eastern countries, identify research gaps, and evaluate methodological constraints. The study protocol, registered as CRD42022314453, conducted a comprehensive database search in PubMed, Scopus, Web of Science, Embase, and Agricola without language restrictions, adhering to PRISMA 2020 guidelines and a structured PECO statement for study selection.

Results
This search identified just five relevant studies within Egypt, Syria, and Jordan. We assessed the Risk of Bias using a comprehensive tool that aligns with WHO/ILO Joint Estimates and incorporates principles from the Navigation Guide RoB tool and RoB-SPEO domains. Furthermore, we conducted a quantitative meta-analysis on homogeneous data. The results of various genotoxicity assays consistently demonstrate a heightened level of DNA damage in individuals exposed to pesticides compared to their non-exposed counterparts. Notably, farmers exposed to pesticides exhibit a significantly increased occurrence of chromosomal translocation (t(14;18)), micronuclei formation, and chromosomal aberrations. It is noteworthy, however, that only two of these studies assessed cytotoxicity indirectly.

Discussion
In addition, the limited availability of detailed exposure data necessitates a cautious interpretation of the findings. This review underscores the imperative for further research on the genotoxicity of occupational pesticide exposure in the Middle East.

Conclusion
By deepening our understanding of the genotoxic effects of pesticide exposure, we can develop more effective strategies to safeguard the health of agricultural workers in Arab countries.
P-512 THE WORKING CONDITIONS OF AGRICULTURAL WORKERS FROM MAGHREB AND SUBSAHARAN AFRICA IN SPAIN. THE AGROMISALUD PROJECT
Authors: Briones-Vozmediano Erica , Rodríguez-Guerrero Luis Alejandro , González-Rodríguez Agustín , Andrés-Cabello Sergio , Jiménez-Lasserrotte Maria del Mar , Mateos Jose Tomás , Ronda-Pérez Elena 
Published: July 2024

Abstract

Introduction
In Spanish agriculture, thousands of foreign workers are hired each year to collect fruits and vegetables. The AGROMISALUD project aims to describe the working conditions of agricultural workers from Magreb and Subsaharan Africa in Spain.

Methods
A multicentre cross-sectional descriptive study was conducted in 4 Spanish regions in 2022. A 43-question questionnaire was designed. Descriptive statistics (frequencies and percentages) were calculated in STATA.13.

Results and discussion
623 agricultural workers (65% men, 34% women) from 21 countries on the African continent were surveyed: 62% North African and 38% sub-Saharan. 40% of the men and 88% of the women were from Morocco. 14% (19%men,5%women) of the sample used chemicals, flammable liquids and gases. 29% (35% men,7%women) had received information or courses on occupational hazards from the company or employer. 46% (60%men,18%women) lifted, carried, or pushed heavy objects of more than 20 kg or more manually at least 10 times a day. 48% (61%men,21%women) did not have the necessary protection such as gloves, masks, helmets, and 54% (50%men, 61%women) did not know their rights and responsibilities about their health and safety at work.

Conclusion
Migrant agricultural workers in Spain need to receive both the required material to prevent injuries at work and information and/or courses on occupational hazards from the company or employee.
P-513 THE USE OF PESTICIDE IN NON-AGRICULTURAL SETTINGS: CAN WE MEASURE THE IMPACT ON THE ENVIRONMENT, WORKERS AND COMMUNITY HEALTH?
Authors: Tassone Paola , Russo Simone , Gherardi Monica , Vasselli Donatella , Gagliardi Diana 
Published: July 2024

Abstract

Introduction
The use of pesticides plays an important role in agricultural-production. However, pesticides are also used in non-agricultural settings, where they can impact on occupational and community health. This study aims to explore the use of herbicides in non-agricultural settings, starting from the railways sector, by outlining in particular the role of regulatory and technical approach related to a sustainable use of pesticides in the EU.

Materials and methods
The study concerned the analysis of EU-legislation on pesticides (Directive 2009/128/EC) and its implementation in Italy, as well as the analysis of herbicides distributed in Italy along the time and, among these, those specifically authorized for non-agricultural use. For this analysis, we used the ISTAT and the Italian Ministry of Health databases.

Results
The preliminary analysis of herbicides sales trend showed an overall decrease over the last years, probably due to the 2009 regulatory package for the sustainable use of pesticides; nevertheless no specific data on non-agricultural use are extractable. The analysis of chemical classes of herbicides revealed that in Italy those allowed for railways essentially derive from research developed in the agricultural sector, thus potentially implying similar aspects of health and safety for workers, the environment and surrounding communities.

Conclusions
The lack of specific data on non-agricultural herbicides, resulting from their non-exclusive authorization, makes it very difficult to quantify their use. The results show the need to improve the information flow on sales and use it to fill this gap for a complete picture of the potential impact of herbicides on workers and the population.
O-341 THE RELATIONSHIP BETWEEN PRESENTEEISM AND OCCUPATIONAL ACCIDENTS: A PROSPECTIVE COHORT STUDY
Authors: Tsutsumi Kakeru , Nagata Tomohisa , Fukui Yuto , Odagami Kiminori , Adi Nuri Purwito , Mori Koji 
Published: July 2024

Abstract

Introduction
Presenteeism is a condition in which an employee is unable to perform adequately due to physical or mental health problems despite being present at work. Although the previous study has shown that presenteeism is associated with near misses, the limitations are that it is a cross-sectional study and the subjects are limited to first responders. This study aims to investigate the relationship between presenteeism and occupational accidents.

Methods
The study design was a prospective cohort study with a baseline survey in March 2022 and a follow-up survey one year later. The independent variable was presenteeism at baseline using WHO-HPQ, classified into four categories. The outcome was the occurrence of occupational accidents from baseline to follow-up. We examined the relationship between presenteeism and occupational accidents using logistic regression analysis. This study was approved by the Ethics Committee of UOEH.

Results
Among 16,629 workers, presenteeism was “0-50%” (n=5,490); “60-70%” (n=5,235); “80%” (n=3,711); and “90-100%” (n=2,193). The odds ratios of each group were 1.46 (95%CI, 1.21-1.77), 1.13 (0.93-1.37), and 1.13 (0.92-1.39), respectively, compared to “90-100%”.

Discussion
Presenteeism may have reduced concentration and judgment, which in turn increased the risk of occupational accidents. The countermeasure for presenteeism may be effective in reducing the risk of occupational accidents.

Conclusion
Presenteeism was associated with the occurrence of occupational accidents.
O-348 BEHIND THE TIMES? ASSOCIATIONS OF WORKING TIME AUTONOMY WITH PSYCHOSOMATIC COMPLAINTS IN HEALTH CARE PERSONNEL
Authors: Riedel-Heller Steffi G , Pabst Alexander , Luppa Melanie , Jung Franziska U 
Published: July 2024

Abstract

Introduction
Flexibility and autonomy of employees with regard to working hours are currently intensively discussed in many sectors. This study investigates how different aspects of working time autonomy are associated with health outcomes such as psychosomatic complaints in health care personnel.

Method
Based on data of the German BAuA Working Time survey, a sample of n = 1,093 employees working in the health care sector were included. Working time autonomy was assessed with five Likert items, psychosomatic complaints during the last 12 months with a complaint list. A latent class analysis (LCA) was conducted to identify distinct classes of health care workers with patterns of more or less autonomy. The association with psychosomatic complaints was investigated using generalized linear models.

Results
Sample Description reveals a mean age of 51.1 year (SD 9.7), 25.3% were female. Psychosomatic health complaints ranged from 0 to 11, with a mean of 4.1 (SD2.9) and stomach discomfort or indigestion, shoulder or neck pain and lower back pain being reported most often. The LCA revealed that three latent classes fitted the data best: 43.9% of health care workers showed a predominantly low, 37.9% medium and 18.1% high degree of working time autonomy. Adjusted for confounding, those with low degrees of autonomy had on average a significantly increased number of psychosomatic complaints, while those with a high degree of autonomy had a reduced number of psychosomatic complaints.

Discussion
The analyses indicate that it is crucial to prospectively consider working time autonomy as an important factor of health and well-being in health care employees.
O-349 IMPACT OF RAMADAN ON SLEEP AND ALERTNESS DISORDERS IN INTENSIVE CARE STAFF AT RABAT UNIVERSITY HOSPITAL
Authors: Laraqui Omar , Manar Nadia , bouri Hicham El , Deschamps Frédéric , Laraqui Hossini Chakib 
Published: July 2024

Abstract

Introduction
The aim of this study was to assess the impact of Ramadan on sleep and alertness in healthcare professionals working in intensive care units.

Method
This cross-sectional epidemiological study involved 152 people (96 on-call and 52-day shift). A self- questionnaire was administered during the third week of Ramadan and the third week after the end of Ramadan. It included socio-demographic and professional data, lifestyle and sleep habits, sleeping and alertness disorders (Epworth scale) and fatigue (Pichot scale).

Results
During Ramadan, changes in dietary and lifestyle habits were reflected in shifted sleep and wake-up schedules. Mean nocturnal sleep duration was 5.9 ± 1.3 h during Ramadan, compared with 7.1 ± 1.5 h after Ramadan. During Ramadan, 46% woke up feeling tired and sleepy, and 53.3% had a headache, compared with 28.3% and 19% respectively after Ramadan. The prevalence of napping increased during Ramadan: 42.1% versus 29.6% after Ramadan. The prevalence of sleep disorders, daytime sleepiness (Epworth &gt; 10) and fatigue (Pichot &gt; 22) was higher during than after Ramadan (79.6%, 86.2% and 44.1% vs. 63.2%, 53.3% and 13.8% respectively).

Discussion
These differences in prevalence were more marked among on-call caregivers than among those working during the day. The prevalence of regular sports increased slightly during Ramadan, while the prevalence of harmful habits remained unchanged, with the exception of alcohol, whose prevalence was zero.

Conclusion
occupational medicine in the hospital sector has an important role to play in raising caregivers’ awareness of the risks associated with bad practices adopted during the month of Ramadan.
P-519 PERCEIVED FATIGUE AND SLEEPINESS AMONG BRAZILIAN AIRLINE PILOTS
Authors: Sampaio Izabela Tissot Antunes , Leandro José , Chiann Chang , Fischer Frida Marina 
Published: July 2024

Abstract

Introduction
Fatigue management rules for civil aviation have changed since 2019 in Brazil. One of the aims of this study was to assess perceived fatigue and sleepiness of Brazilian airline pilots.

Methods
Fifty-one airline pilots participated. They scored perceived fatigue and sleepiness three times a day, during 15 consecutive days, along working days and off-days using Samn-Perelli Scale-SPS and Karolinska Sleepiness Scale-KSS. A total of 3,434 records was analyzed using a binomial mixed effects model with logit link according to duty starting times: night (00h00-06h00), early morning (06h01-07h59), morning (08h00h-12h00), afternoon (12h01-17:59) and evening (18h00-23h59). This study was approved by the Ethics Committee of University of Sao Paulo (36370720.9.0000.5421).

Results
Perceived severe fatigue (scores 6,7 in SPS) was higher during nighttime work when compared to those starting in the morning (three times the odds), afternoon (six times) and evening (four times). Early starts also presented higher odds for severe fatigue than afternoon (five times) and night (three times) periods. Perceived excessive sleepiness (scores 7,8,9 in KSS) followed similar trends, but was also higher in the evening when compared to afternoon (three times the odds), in the morning compared to afternoon (twice the odds) and at night compared to early morning (twice the odds).

Discussion and conclusion
The most perceived disruptive schedules were those that included nighttime and started early in the morning, both for severe fatigue and excessive sleepiness; and those that started during evening hours for excessive sleepiness. Safety barriers to effectively manage those working times are needed.
Acknowledgments: CNPq (423231/2018-9; 306963/2021-3); FAPESP(Itapar); ANAC.