bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leukoreduced whole blood–derived platelets treated with antimicrobial peptides maintain in vitro properties during storage
Authors: Bosch‐Marcé Marta , Seetharaman Shalini , Kurtz James , Mohan Ketha V.K. , Wagner Stephen J. , Atreya Chintamani D. 
Published: January 2014

BackgroundBacterial sepsis is still a complication in patients transfused with stored platelets (PLTs). We have recently demonstrated that selected antimicrobial peptides (AMPs) have bactericidal activity in bacteria‐spiked PLTs. In a subsequent preclinical study, we have also shown that these AMPs do not elicit antibody response in rabbits and treatment of PLTs before transfusion does not affect their in vivo recovery and survival in severe combined immunodeficient mice. Here we have selected two such AMPs, Arg‐Trp (RW) repeats of tri‐ and tetra‐peptides (RW3 and RW4) in combination (i.e., cocktail), and evaluated their effect on the in vitro properties of PLTs.Study Design and MethodsLeukoreduced ABO‐ and D‐identical whole blood–derived PLT concentrates were pooled and divided into two 60‐mL aliquots in CLX storage bags. On Day 0, one bag received a peptide cocktail of RW3 plus RW4 at 0.01 mmol/L final concentration (test) and the other bag received only phosphate‐buffered saline (PBS), the AMP solvent (control). The treated PLTs were stored for 7 days at 20 to 24°C. Samples were collected on Days 1, 5, and 7 to evaluate the in vitro properties of PLTs with standard assays.ResultsIn vitro properties of the RW3 plus RW4 cocktail–treated PLTs were similar to those incubated with PBS only. There were no significant differences between the control and test PLTs during the 7‐day storage.ConclusionLeukoreduced whole blood–derived PLTs treated with a mixture of RW3 and RW4 peptides maintain their in vitro properties during 7 days of storage.
Persistent neurogenic bladder dysfunction due to infantile botulism
Authors: Breinbjerg Anders , Rittig Søren , Kamperis Konstantinos 
Published: January 2014

We present a child, 5 months of age, diagnosed with infantile botulism, showing the signs of neurogenic bladder dysfunction. The patient presented with progressive muscle weakness, hypotonia, suckling and swallowing problems and absent peripheral reflexes at clinical examination. Botulinum neurotoxin type A was detected in her serum, confirming the diagnosis. Starting at day 6, the girl presented with a urinary retention initially necessitating free bladder drainage and subsequently intermittent catheterisation. After 6 weeks in intensive care, the patient recovered but the bladder underactivity persisted. Four months following recovery, a urodynamic evaluation was performed, showing a near normal detrusor activity and normal bladder emptying, and the catheterisation was ceased. At 6 months, the girl was diagnosed with a urinary tract infection and bladder emptying problems, which persisted, and clean intermittent catheterisation was started. The final urodynamic evaluation, a year and a half after her initial presentation, revealed a normal detrusor activity and an adequate bladder emptying.
The Changing Public Image of Smoking in the United States: 1964–2014
Authors: Cummings K. Michael , Proctor Robert N. 
Published: January 2014

Abstract
Tobacco use behaviors in the U.S. have changed significantly over the past century. After a steep increase in cigarette use rates over the first half of the 20th century, adult smoking prevalence rates started declining from their peak reached in 1964. Improved understanding of the health risks of smoking has been aided by the U.S. Surgeon General's Reports, issued on a nearly annual basis starting in 1964. Among the many forces driving down smoking prevalence were the recognition of tobacco use as an addiction and cause of cancer, along with concerns about the ill effects of breathing secondhand smoke. These factors contributed to the declining social acceptance of smoking, especially with the advent of legal restrictions on smoking in public spaces, mass media counter-marketing campaigns, and higher taxes on cigarettes. This article reviews some of the forces that have helped change the public image of smoking, focusing on the 50 years since the 1964 Surgeon General's Report on smoking and health. Cancer Epidemiol Biomarkers Prev; 23(1); 32–36. ©2014 AACR.
Using Climate Divisions to Analyze Variations and Trends in Alaska Temperature and Precipitation
Authors: Bieniek Peter A. , Walsh John E. , Thoman Richard L. , Bhatt Uma S. 
Published: January 2014

AbstractBy extending the record of Alaskan divisional temperature and precipitation back in time, regional variations and trends of temperature and precipitation over 1920–2012 are documented. The use of the divisional framework highlights the greater spatial coherence of temperature variations relative to precipitation variations.The divisional time series of temperature are characterized by large interannual variability superimposed upon low-frequency variability, as well as by an underlying trend. Low-frequency variability corresponding to the Pacific decadal oscillation (PDO) includes Alaska’s generally warm period of the 1920s and 1930s, a cold period from the late 1940s through the mid-1970s, a warm period from the late 1970s through the early 2000s, and a cooler period in the most recent decade. An exception to the cooling of the past decade is the North Slope climate division, which has continued to warm. There has been a gradual upward trend of Alaskan temperatures relative to the PDO since 1920, resulting in a statewide average warming of about 1°C.In contrast to temperature, variations of precipitation are less consistent across climate divisions and have much less multidecadal character. Thirty-year trends of both variables are highly sensitive to the choice of the subperiod within the overall 93-yr period. The trends also vary seasonally, with winter and spring contributing the most to the annual trends.
The Interpretation and Use of Biases in Decadal Climate Predictions
Authors: Hawkins Ed , Dong Buwen , Robson Jon , Sutton Rowan , Smith Doug 
Published: January 2014

Abstract
Decadal climate predictions exhibit large biases, which are often subtracted and forgotten. However, understanding the causes of bias is essential to guide efforts to improve prediction systems, and may offer additional benefits. Here the origins of biases in decadal predictions are investigated, including whether analysis of these biases might provide useful information. The focus is especially on the lead-time-dependent bias tendency. A “toy” model of a prediction system is initially developed and used to show that there are several distinct contributions to bias tendency. Contributions from sampling of internal variability and a start-time-dependent forcing bias can be estimated and removed to obtain a much improved estimate of the true bias tendency, which can provide information about errors in the underlying model and/or errors in the specification of forcings. It is argued that the true bias tendency, not the total bias tendency, should be used to adjust decadal forecasts.
The methods developed are applied to decadal hindcasts of global mean temperature made using the Hadley Centre Coupled Model, version 3 (HadCM3), climate model, and it is found that this model exhibits a small positive bias tendency in the ensemble mean. When considering different model versions, it is shown that the true bias tendency is very highly correlated with both the transient climate response (TCR) and non–greenhouse gas forcing trends, and can therefore be used to obtain observationally constrained estimates of these relevant physical quantities.
Quantifying Wind Turbine Wake Characteristics from Scanning Remote Sensor Data
Authors: Aitken Matthew L. , Banta Robert M. , Pichugina Yelena L. , Lundquist Julie K. 
Published: January 2014

Abstract
Because of the dense arrays at most wind farms, the region of disturbed flow downstream of an individual turbine leads to reduced power production and increased structural loading for its leeward counterparts. Currently, wind farm wake modeling, and hence turbine layout optimization, suffers from an unacceptable degree of uncertainty, largely because of a lack of adequate experimental data for model validation. Accordingly, nearly 100 h of wake measurements were collected with long-range Doppler lidar at the National Wind Technology Center at the National Renewable Energy Laboratory in the Turbine Wake and Inflow Characterization Study (TWICS). This study presents quantitative procedures for determining critical parameters from this extensive dataset—such as the velocity deficit, the size of the wake boundary, and the location of the wake centerline—and categorizes the results by ambient wind speed, turbulence, and atmospheric stability. Despite specific reference to lidar, the methodology is general and could be applied to extract wake characteristics from other remote sensor datasets, as well as computational simulation output.
The observations indicate an initial velocity deficit of 50%−60% immediately behind the turbine, which gradually declines to 15%−25% at a downwind distance x of 6.5 rotor diameters (D). The wake expands with downstream distance, albeit less so in the vertical direction due to the presence of the ground: initially the same size as the rotor, the extent of the wake grows to 2.7D (1.2D) in the horizontal (vertical) at x = 6.5D. Moreover, the vertical location of the wake center shifts upward with downstream distance because of the tilt of the rotor.
Acute kidney injury due to anti-tuberculosis drugs: a five-year experience in an aging population
Authors: Chang Chia-Hao , Chen Yen-Fu , Wu Vin-Cent , Shu Chin-Chung , Lee Chih-Hsin , Wang Jann-Yuan , Lee Li-Na , Yu Chong-Jen 
Published: January 2014

Abstract

Background
Patients on anti-tuberculosis treatment may develop acute kidney injury (AKI), but little is known about the renal outcome and prognostic factors, especially in an aging population. This study aimed to calculate the incidence of AKI due to anti-TB drugs and analyze the outcomes and predictors of renal recovery.

Methods
From 2006 to 2010, patients on anti-TB treatment were identified and their medical records reviewed. Acute kidney injury was defined according to the criteria established by the AKI Network, while renal recovery was defined as a return of serum creatinine to baseline. Predictors of renal recovery were identified by Cox regression analysis.

Results
Ninety-nine out of 1394 (7.1%) patients on anti-TB treatment had AKI. Their median age was 68 years and there was male predominance. Sixty (61%) developed AKI within two months of anti-TB treatment, including 11 (11%) with a prior history of rifampin exposure. Thirty (30%) had co-morbid chronic kidney disease or end-stage renal disease. The median time of renal recovery was 39.6 days (range, 1–180 days). Factors predicting renal recovery were the presence of fever, rash, and gastro-intestinal disturbance at the onset of AKI. Sixty-two of the 71 (87%) patients who recovered from AKI had successful re-introduction or continuation of rifampin.

Conclusions
Renal function impairment is not a rare complication during anti-TB treatment in an elderly population. The presence of fever and rash may be associated with renal recovery. Rifampin can still be used in most patients who recover from AKI.
Enhanced cytotoxic effect of radiation and temozolomide in malignant glioma cells: targeting PI3K-AKT-mTOR signaling, HSP90 and histone deacetylases
Authors: Choi Eun Jung , Cho Bong Jun , Lee David J , Hwang Yeo Hyeon , Chun Sun Ha , Kim Hans H , Kim In Ah 
Published: January 2014

Abstract

Background
Despite aggressive treatment with radiation therapy and concurrent adjuvant temozolomide (TMZ), glioblastoma multiform (GBM) still has a dismal prognosis. We aimed to identify strategies to improve the therapeutic outcome of combined radiotherapy and TMZ in GBM by targeting pro-survival signaling from the epidermal growth factor receptor (EGFR).

Methods
Glioma cell lines U251, T98G were used. Colony formation, DNA damage repair, mode of cell death, invasion, migration and vasculogenic mimicry as well as protein expression were determined.

Results
U251 cells showing a low level of methyl guanine transferase (MGMT) were highly responsive to the radiosensitizing effect of TMZ compared to T98G cells having a high level of MGMT. Treatment with a dual inhibitor of Class I PI3K/mTOR, PI103; a HSP90 inhibitor, 17-DMAG; or a HDAC inhibitor, LBH589, further increased the cytotoxic effect of radiation therapy plus TMZ in U251 cells than in T98G cells. However, treatment with a mTOR inhibitor, rapamycin, did not discernibly potentiate the radiosensitizing effect of TMZ in either cell line. The mechanism of enhanced radiosensitizing effects of TMZ was multifactorial, involving impaired DNA damage repair, induction of autophagy or apoptosis, and reversion of EMT (epithelial-mesenchymal transition).

Conclusions
Our results suggest possible strategies for counteracting the pro-survival signaling from EGFR to improve the therapeutic outcome of combined radiotherapy and TMZ for high-grade gliomas.
Social, behavioral, and sleep characteristics associated with depression symptoms among undergraduate students at a women’s college: a cross-sectional depression survey, 2012
Authors: Wilson Katherine T , Bohnert Ashley E , Ambrose Alex , Davis Destiny Y , Jones Dina M , Magee Matthew J 
Published: January 2014

Abstract

Background
The association between student characteristics and depression among students attending women’s colleges (single-sex institutions of higher education that exclude or limit males from admission) is poorly understood. Our objective was to estimate the prevalence of depression and determine behavioral and social characteristics associated with depression among students attending a women’s college.

Methods
We administered a cross-sectional Internet-based survey between April and May 2012 to students (n = 277) enrolled at a private women’s college in the southeastern US. Center for Epidemiologic Studies Depression (CES-D) and Depression Anxiety Stress Scale 21 (DASS-21) instruments measured self-reported depression. Bivariate and multivariable logistic regression methods were used to estimate adjusted associations.

Results
Prevalence of depression measured by CES-D and DASS-21 instruments was 26.3% (95% confidence interval [CI] 20.8-32.3%) and 26.0% (95% CI 20.4-32.3%), respectively. After adjusting for confounders, absence of strong social support (prevalence odds ratio [OR] = 4.3, 95% CI 1.4-13.7), history of mental health disorder (OR = 4.8 95% CI 1.9-12.4), and poor sleep hygiene (OR = 2.8, 95% CI 1.3-5.8) were associated with depression.

Conclusions
This cross-sectional survey identified absence of strong social support, history of mental health disorder, and poor sleep hygiene as potential predictors of depression among students attending a women’s college. Further investigation of these factors may inform depression interventions for students attending women’s colleges and other undergraduate student populations.
Preconditioning somatothermal stimulation on Qimen (LR14) reduces hepatic ischemia/reperfusion injury in rats
Authors: Hsieh Cheng-Chu , Hsieh Shu-Chen , Chiu Jen-Hwey , Wu Ying-Ling 
Published: January 2014

AbstractBackgroundIn human beings or animals, ischemia/reperfusion (I/R) injury of the liver may occur in many clinical conditions, such as circulating shock, liver transplantation and surgery and several other pathological conditions. I/R injury has a complex pathophysiology resulting from a number of contributing factors. Therefore, it is difficult to achieve effective treatment or protection by individually targeting the mediators. This study aimed at studying the effects of local somatothermal stimulation preconditioning on the right Qimen (LR14) on hepatic I/R injury in rats.MethodsEighteen male Sprague-Dawley rats were randomly divided into three groups. The rats were preconditioned with thermal tolerance study, which included one dose of local somatothermal stimulation (LSTS) on right Qimen (LR14) at an interval of 12 h, followed by hepatic ischemia for 60 min and then reperfusion for 60 min. Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) have been used to assess the liver functions, and liver tissues were taken for the measurements such as malondialdehyde (MDA), glutathione (GSH), catalase (CAT), superoxidase dismutase (SOD), and myeloperoxidase (MPO).ResultsThe results show that the plasma ALT and AST activities were higher in the I/R group than in the control group. In addition, the plasma ALT and AST activities decreased in the groups that received LSTS. The hepatic SOD levels reduced significantly by I/R injury. Moreover, the hepatic MPO activity significantly increased by I/R injury while it decreased in the groups given LSTS.ConclusionsOur findings show that LSTS provides a protective effects on the liver from the I/R injury. Therefore, LSTS might offer an easy and inexpensive intervention for patients who have suffered from I/R of the liver especially in the process of hepatotomy and hepatic transplantation.
Structural and optical characterizations of InPBi thin films grown by molecular beam epitaxy
Authors: Gu Yi , Wang Kai , Zhou Haifei , Li Yaoyao , Cao Chunfang , Zhang Liyao , Zhang Yonggang , Gong Qian , Wang Shumin 
Published: January 2014

Abstract
InPBi thin films have been grown on InP by gas source molecular beam epitaxy. A maximum Bi composition of 2.4% is determined by Rutherford backscattering spectrometry. X-ray diffraction measurements show good structural quality for Bi composition up to 1.4% and a partially relaxed structure for higher Bi contents. The bandgap was measured by optical absorption, and the bandgap reduction caused by the Bi incorporation was estimated to be about 56 meV/Bi%. Strong and broad photoluminescence signals were observed at room temperature for samples with x
Bi < 2.4%. The PL peak position varies from 1.4 to 1.9 μm, far below the measured InPBi bandgap.
Graphene’s cousin: the present and future of graphane
Authors: Zhou Chao , Chen Sihao , Lou Jianzhong , Wang Jihu , Yang Qiujie , Liu Chuanrong , Huang Dapeng , Zhu Tonghe 
Published: January 2014

AbstractThe so-called graphane is a fully hydrogenated form of graphene. Because it is fully hydrogenated, graphane is expected to have a wide bandgap and is theoretically an electrical insulator. The transition from graphene to graphane is that of an electrical conductor, to a semiconductor, and ultimately to an electrical insulator. This unique characteristic of graphane has recently gained both academic and industrial interest. Towards the end of developing novel applications of this important class of nanoscale material, computational modeling work has been carried out by a number of theoreticians to predict the structures and electronic properties of graphane. At the same time, experimental evidence has emerged to support the proposed structure of graphane. This review article covers the important aspects of graphane including its theoretically predicted structures, properties, fabrication methods, as well as its potential applications.
Hypersensitivity to oxaliplatin: clinical features and risk factors
Authors: Parel Marie , Ranchon Florence , Nosbaum Audrey , You Benoit , Vantard Nicolas , Schwiertz Vérane , Gourc Chloé , Gauthier Noémie , Guedat Marie-Gabrielle , He Sophie , Kiouris Eléna , Alloux Céline , Vial Thierry , Trillet-Lenoir Véronique , Freyer Gilles , Berard Frédéric , Rioufol Catherine 
Published: January 2014

Abstract

Background
Oxaliplatin-based regimens induce a potential risk of hypersensitivity reaction (HSR), with incidence varying from 10% to 25% and lack of clearly identified risk factors. The present study aimed to assess incidence and risk factors in HSR.

Methods
All patients treated with oxaliplatin in the Medical Oncology Department of the Lyon Sud University Hospital (Hospices Civils de Lyon, France) from October 2004 to January 2011 were enrolled. Incidence and severity of HSR were analyzed retrospectively and the potential clinicopathological covariates were tested on univariate and multivariate analysis.

Results
A total of 1,221 doses of oxaliplatin were administered for 191 patients, 8.9% of whom experienced an HSR. Seventeen HSRs were observed, with 1.6% grade 3 and no grade 4 events. The first reaction appeared after a median of 3 oxaliplatin infusions. Using univariate analysis, HSR was associated with younger age (mean age, 56.2 years; p = 0.04), female gender (p = 0.01) and prior exposure to platinum salts (p = 0.02). No increased risk was associated with mean dose or with presence of atopic background. Multivariate analysis confirmed that women were at higher risk of oxaliplatin HSR than men (p < 0.05). Reintroduction of oxaliplatin was effective in 64.7% of hypersensitive patients using an appropriate premedication strategy. Patients who experienced a grade 3 HSR were not rechallenged.

Conclusion
The risk of developing oxaliplatin HSR should not be underestimated (8.9% of patients). The medical team’s vigilance should be increased with women, younger patients and patients with prior exposure to platinum salts.
Changes of direction during high-intensity intermittent runs: neuromuscular and metabolic responses
Authors: Hader Karim , Mendez-Villanueva Alberto , Ahmaidi Said , Williams Ben K , Buchheit Martin 
Published: January 2014

AbstractBackgroundThe ability to sustain brief high-intensity intermittent efforts (HIE) is meant to be a major attribute for performance in team sports. Adding changes of direction to HIE is believed to increase the specificity of training drills with respect to game demands. The aim of this study was to investigate the influence of 90°-changes of direction (COD) during HIE on metabolic and neuromuscular responses.MethodsEleven male, team sport players (30.5 ± 3.6 y) performed randomly HIE without (straight-line, 2×[10× 22 m]) or with (2×[10× ~16.5 m]) two 90°-COD. To account for the time lost while changing direction, the distance for COD runs during HIE was individually adjusted using the ratio between straight-line and COD sprints. Players also performed 2 countermovement (CMJ) and 2 drop (DJ) jumps, during and post HIE. Pulmonary oxygen uptake (VO2), quadriceps and hamstring oxygenation, blood lactate concentration (Δ[La]b), electromyography amplitude (RMS) of eight lower limb muscles and rating of perceived exertion (RPE) were measured for each condition.ResultsDuring HIE, CODs had no substantial effects on changes inVO2, oxygenation, CMJ and DJ performance and RPE (all differences in the changes rated as unclear). Conversely, compared with straight-line runs, COD-runs were associated with a possibly higher Δ[La]b(+9.7 ± 10.4%, with chances for greater/similar/lower values of 57/42/0%) and either a lower (i.e., −11.9 ± 14.6%, 2/13/85 for semitendinosus and −8.5 ± 9.3%, 1/21/78 for lateral gastrocnemius) or equivalent decrease in electromyography amplitude.ConclusionAdding two 90°-CODs on adjusted distance during two sets of HIE is likely to elicit equivalent decreases in CMJ and DJ height, and similar cardiorespiratory and perceptual responses, despite a lower average running speed. A fatigue-induced modification in lower limb control observed with CODs may have elicited a selective reduction of electromyography activity in hamstring muscles and may induce, in turn, a potential mechanical loss of knee stability. Therefore, changing direction during HIE, with adjusted COD running distances, might be an effective training practice 1) to manipulate some components of the acute physiological load of HIE, 2) to promote long-term COD-specific neuromuscular adaptations aimed at improving performance and knee joint stability.