bluuebunny/crossref_metadata_2025_split huggingface dataset:
Edukasi Cara Penyimpanan Obat Melalui Kegiatan Promosi Kesehatan di Posyandu Lansia Ar-Rahman Banjarmasin
Authors: Puri Rizki Swastika , Mardiati Nurul , Annissa Rahmi , Setiawan Deni 
Published: July 2024

Penyimpanan obat penting dilakukan untuk menjaga stabilitas dan efektivitas obat. Penerapan cara menyimpan obat yang kurang tepat akan berdampak terhadap perubahan fisik, sifat, ataupun kerusakan obat. Kegiatan promosi kesehatan ini bertujuan untuk meningkatkan pengetahuan lansia terhadap tata cara penyimpanan obat dan batasan waktu penggunaan obat setelah disimpan. Promosi kesehatan dilaksanakan dengan metode ceramah menggunakan media poster sebagai alat bantu yang berisi tentang cara menyimpan obat yang baik. Materi yang disampaikan yaitu cara menyimpan obat sesuai bentuk sediaan, batasan waktu penggunaan obat, hal yang harus diperhatikan dan dihindari selama proses penyimpanan obat. Kegiatan promosi kesehatan di lanjutkan dengan sesi diskusi dan tanya jawab. Evaluasi dilaksanakan secara lisan sesuai dengan jawaban benar/salah dan dilakukan perhitungan persentase rata-rata nilai pretest/posttest peserta. Berdasarkan hasil kegiatan yang diikuti oleh 15 orang responden menunjukkan terjadi peningkatan pengetahuan terkait materi yang disampaikan, hal ini diketahui berdasarkan persentase nilai rata-rata pretest sebesar 56% dan posttest sebesar 94,6%. Kata Kunci: Beyond Use Date, Expired Date, Efektivitas, Stabilitas Drug storage is important to maintain the stability and effectiveness of the drug. Implementing inappropriate methods for storing medicines will result in physical changes, properties or damage to the medicine. This health promotion activity aims to increase the elderly's knowledge of medication storage procedures and time limits for medication use after storage. Health promotion is carried out using the lecture method using poster media as a tool that contains information about how to store medicine properly. The material presented is how to store drugs according to the dosage form, time limits for drug use, things to pay attention to and avoid during the drug storage process. Health promotion activities were continued with discussion and question and answer sessions. Evaluation is carried out orally according to correct/wrong answers and the average percentage of participants' pretest/posttest scores is calculated. Based on the results of activities attended by 15 respondents, it showed that there had been an increase in knowledge regarding the material presented, this was known based on the percentage of the average pretest score of 56% and posttest of 94.6%.
Pemberdayaan UMKM dalam Digitalisasi Marketing dan Branding Melalui Pendaftaran Merek Dagang
Authors: Saputera Mochammad Maulidie Alfiannor , Rahmiati Rahmiati , Adhipurna Novian 
Published: July 2024

Keberadaan usaha mikro, kecil dan menengah (UMKM) di Indonesia mempunyai peranan yang strategis dalam rangka meningkatkan perekonomian negara. Digitalisasi marketing dan branding produk sangat penting pada era sekarang, maka dari itu UMKM sudah harus ikut berkontribusi dalam dunia digitalisasi. Tujuan dalam kegiatan ini yaitu membantu pendftaran sertifikat merek dagang bagi UMKM dan meningkatkan pengetahuan dalam dalam penjualan melalui digital marketing. Metode pada kegiatan ini yaitu mengumpulkan data pendaftaran merek dagang dan sosialisasi digital marketing dan branding dengan kriteria UMKM berada di wilayah Kabupaten Banjar Kalimantan Selatan, memproduksi minuman dari bahan alam dan produk telah terdaftar P-IRT. Jumlah khalayak sasaran pada kegiatan ini yaitu sebanyak 6 UMKM. Berdasarkan hasil kegiatan dari 6 UMKM yang mengikuti pemberdayaan hanya 3 UMKM yang bersedia mengumpulkan dokumen dan mendaftarkan merk dagang. Kegiatan sosialisasi digital marketing dan branding memberikan wawasan kepada para pemilik usaha terkait cara marketing dan branding yang efektif dan efisien sdengan tujuan meningkatkan penjualan produk. Kegiatan sosialisasi digital marketing dan branding juga menghasilkan 3 video promosi produk yang menarik dan berkualitas. Kesimpulan pengabdian dari 6 UMKM diperoleh 50% UMKM telah mendaftarkan merek dagang dan 50% UMKM telah membuat video promosi yang telah di bagikan pada media sosial UMKM masing-masing Kata Kunci: Pemberdayaan, UMKM, Digitalisasi, Marketing, Branding The existence of micro, small and medium enterprises (MSMEs) in Indonesia has a strategic role in improving the country's economy. Digitalization of marketing and product branding is very important in the current era, therefore MSMEs must contribute to the world of digitalization. The aim of this activity is to help register trademark certificates for MSMEs and increase knowledge in sales through digital marketing. The method for this activity is collecting trademark registration data and socializing digital marketing and branding with the criteria that MSMEs are located in the Banjar Regency area of South Kalimantan, produce drinks from natural ingredients and the products are P-IRT registered. The number of target audiences for this activity is 6 MSMEs. Based on the results of the activities of the 6 MSMEs that took part in the empowerment, only 3 MSMEs were willing to collect documents and register trademarks. Digital marketing and branding outreach activities provide insight to business owners regarding effective and efficient marketing and branding methods with the aim of increasing product sales. Digital marketing and branding outreach activities also produced 3 attractive and high-quality product promotional videos. The conclusion of the service from 6 MSMEs was that 50% of MSMEs had registered trademarks and 50% of MSMEs had made promotional videos which had been shared on their respective MSMEs' social media.
Penerapan Komunikasi Empatik Pada Penanganan Krisis Studi kasus Meledaknya Depo Pertamina Plumpang
Authors: Zuhdi Ilyas Naufal , Ayuningtyas Fitria 
Published: July 2024

Krisis dapat terjadi pada setiap organisasi secara tiba-tiba kapan dan dimana saja, setiap organisasi pasti pernah mengalami suatu krisis. Salah satu krisis yang pernah terjadi pada PT. Pertamina yaitu meledaknya depo Pertamina Plumpang. Meledaknya depo Pertamina Plumpang mampu menyebabkan krisis karena banyaknya korban jiwa yang disebabkan oleh ledakan. PT Pertamina merespon krisis tersebut dengan cepat, strategi yang diterapkan merupakan strategi pembangunan kembali (rebuild) yaitu dengan cara memberikan pernyataan bahwa Pertamina siap bertanggung jawab secarah penuh terhadap kejadian tersebut, pertamina juga menyampaikan permohonan maaf dan rasa prihatin, serta memberikan kompensasi kepada para korban. Pendekatan emosional dilakukan Pertamina untuk mendapatkan kepercayaan masyarakat kembali, salah satunya dengan cara komunikasi empati, PT. Pertamina berusaha untuk memperkuat posisinya di mata stakeholder dengan melakukan permohonan maaf, kompensasi, dan juga memposisikan diri sebagai korban.
Prediction model of M2 with early-stage hepatocellular carcinoma based on multiple machine learning
Authors: Xia Guoyi , Yu Zeyan , Lu Shaolong , Wang Xiaobo , Zhao Yuanquan , Chen Jie 
Published: July 2024

Abstract

Background: Microvascular invasion (MVI) is a crucial factor for early recurrence and poor outcomes in hepatocellular carcinoma (HCC). However, there are few studies on M2 classification. We aimed to build a predictive model for M2 in early-stage HCC, assisting clinical decision-making.
Methods: We retrospectively enrolled 451 patients with early-stage HCC and employed multiple machine learning algorithms to identify the risk factors influencing the robustness of M2. Model performance was evaluated using receiver operating characteristic (ROC) curve, calibration curve, decision curve analysis (DCA)，and clinical impact curve (CIC).
Results: There were 363 M0 and 88 M2 cases. Differences in recurrence-free survival (RFS) and overall survival(OS) between the M0 and M2 groups were statistically significant (P <0.0001). Complement C3, tumor size> 5cm, incomplete tumor capsule, and Edmondson-Steiner stage III-IV were independent risk factors for M2.The prediction model showed an area under the receiver operating characteristic curve(AUROC) of 0.765 and 0.807 in the training and validation groups, respectively. Calibration curves showed good agreement between actual and predicted M2 risks, and the DCA and CIC showed a significant clinical efficacy.
Conclusion: The nomogram-based model had a good predictive effect for M2 in patients with early-stage HCC ,providing guidance for treatment decisions.
Clinical outcomes of retrograde percutaneous pinning for shaft fracture of metacarpal bone: A case series
Authors: Ushijima Takahiro , Ogawa Hikaru , Kojima Tetsuo 
Published: July 2024

Abstract

Background
Surgical treatment should be considered for metacarpal fractures that have severe angulation or shortening. Percutaneous pinning is a useful technique in that it is minimally invasive. Insertion of Kirschner wires using retrograde pinning is easier than that using antegrade or transverse pinning. The purpose of this study is to evaluate the functional outcomes of retrograde pinning.
Methods
Thirteen patients (15 fingers) were enrolled in this prospective study. All patients were treated using percutaneous retrograde pinning following a brachial plexus block. Two intramedullary Kirschner wires were inserted from the metacarpal head to its base. Clinical outcomes included range of motion (ROM), postoperative complications, and evaluation using the Quick Disabilities of the Arm, Shoulder, and Hand score at final follow up.
Results
ROM in extension/flexion for each joint at final follow up was: metacarpal phalangeal (MP) joint 3.1°/87.1°; proximal interphalangeal (PIP) joint 2.0°/103.3°; and distal interphalangeal (DIP) joint 0°/74.1°. The percent total active ROM was 91.9% and the Quick-DASH score was 2.7 out of 100. Pin tract infections occurred in two fingers and were treated with oral antibiotics.
Conclusions
In this study, retrograde Kirschner wire fixation was an acceptable technique for the treatment of displaced metacarpal fractures. This simple technique can correct deformity and provide good clinical outcomes.
WITHDRAWN: Assessment of Professional Behaviour: An Imperative Need in the Medical Curriculum
Authors: Shahid Muhammad Siddique , Mushtaq Mazhar , Usman Muhammad Ahmed , Jihwaprani Muhammad Candragupta , Siddique Rahemeen 
Published: July 2024

Abstract

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Addressing the Second Victim Phenomenon among Community Pharmacists and Its Impact on Clinical Pharmacy Practice: A Consensus Study
Authors: Zimonjić Ivana , Marinković Valentina , Mira José Joaquín , Djokic Borivoje-Boris , Odalović Marina 
Published: July 2024

Abstract

Background: The second victim phenomenon, denoting the harmful effects of patient safety incidents on healthcare practitioners, remains insufficiently examined within the pharmacy workforce.
Aim: This study aimed to investigate the second victim phenomenon in community pharmacies across Serbia, examining its triggers, contexts, and effects on pharmacists’ health, well-being, and implications towards pharmaceutical care.
Method: Thisconsensus study, involving 27 pharmacists with prior experience in the second victim phenomenon, employed the Nominal Group Technique in three groups. The final rank was calculated using the van Breda methodology, where the higher values present a higher impact. Statistical evaluation was applied to ascertain the distribution of events, investigate the potential relationships between event categories and patient outcomes, and determine the subsequent impact on pharmacists.
Results: "Patient-centric anxiety" (6.8) was the top mental health issue, followed by "Personal responsibility and resilience" and "Future concerns and career aspirations" (6.0 each). The dominant support was "Colleague/Peer support" (5.3). Significant patient safety incidents were "Inadequate pharmaceutical service" (8.0) and "Wrong drug dispensed" (7.8). In community pharmacies, 63.0% of incidents involved dispensing errors, with "near misses" or "no harm incidents" at 33.3% each and "harmful incidents" at 25.9%. Transcripts indicate that lack of supervision, crowding, and storage issues led to errors, highlighting the need for better dispensing verification and pharmacist training.
Conclusion: This study highlights the profound impact of the second victim phenomenon on pharmacists, which often stems from breaches in basic practice standards. Unmanaged, it worsens quality and safety in pharmaceutical care and severely threatens pharmacists' well-being.
An assessment of the genomic structural variation landscape in Sub-Saharan African populations
Authors: Lombard Zané , Wiener Emma , Cottino Laura , Botha Gerrit , Nyangiri Oscar , Noyes Harry , MacLeod Annette , Jakubosky David , Adebamowo Clement , Awadalla Philip , Landouré Guida , Matshaba Mogomotsi , Matovu Enock , Ramsay Michele , Simo Gustave , Simuunza Martin , Tiemessen Caroline , Wonkam Ambroise , Sahibdeen Venesa , Krause Amanda , Hazelhurst Scott 
Published: July 2024

Abstract

Structural variants are responsible for a large part of genomic variation between individuals and play a role in both common and rare diseases. Databases cataloguing structural variants notably do not represent the full spectrum of global diversity, particularly missing information from most African populations. To address this representation gap, we analysed 1,091 high-coverage African genomes, 545 of which are public data sets, and 546 which have been analysed for structural variants for the first time. Variants were called using five different tools and datasets merged and jointly called using SURVIVOR. We identified 67,795 structural variants throughout the genome, with 10,421 genes having at least one variant. Using a conservative overlap in merged data, 6,414 of the structural variants (9.5%) are novel compared to the Database of Genomic Variants. This study contributes to knowledge of the landscape of structural variant diversity in Africa and presents a reliable dataset for potential applications in population genetics and health-related research.
Effect of breathing exercises to prevent pulmonary complications in patients undergoing coronary artery bypass graft surgery: A pilot study
Authors: Li Chao , Huo Cuiyuan , Li Hongli , Zhang Zichang , Zhang Ping 
Published: July 2024

Abstract

Objective: To determine if perioperative breathing exercises can reduce the incidence of postoperative pulmonary complications in patients undergoing coronary artery bypass graft (CABG)surgery.
Subjects: This study was conducted in the cardiac surgery department at Xuanwu Hospital Capital Medical University Institute of Cardiology. The sample size was 30.
Intervention: Patients were randomized into a control group and an intervention group. Patients in the intervention group received perioperative breathing exercises, including balloon-blowing exercises, coughing, and deep breathing. The control group received standard perioperative care without any breathing exercises. The primary outcome measure was the incidence of postoperative pulmonary complications; the secondary outcome measures were the evaluation of the effect of perioperative breathing exercises on arterial oxygenation, patient satisfaction, and a six-minute walk test (6MWT).
Results: Incidences of postoperative pulmonary complications in the breathing exercises group were lower than that in the control group (1/15 [6.7%] vs 7/15 [46.7%]; P=0.013). Partial pressure of oxygen(PaO2) on the intraoperative and after tracheal were significantly higher in the breathing exercises group than in the control group (P<0.05). Distance walked by patients undergoing breathing exercises was longer than the control group (264.33m vs 214.13m). Higher patient satisfaction (P<0.05) was achieved in the intervention group compared to the control group.
Conclusion: The findings of our pilot study suggest that perioperative breathing exercises may reduce the incidence of postoperative pulmonary complications and preserve arterial oxygenation after coronary artery bypass graft surgery (CABG). A larger study is warranted to confirm these results and their possible clinical consequences.
Epigenetic age prediction drifts resulting from next-generation methylation arrays
Authors: Garma Leonardo D. , Quintela-Fandino Miguel 
Published: July 2024

Abstract

Background
Epigenetic clocks based on DNA methylation data are routinely used to obtain surrogate measures of biological age and estimate epigenetic age acceleration rates. These tools are mathematical models that rely on the methylation state of specific sets of CpG islands quantified using microarrays. The set of CpG islands probed in the microarrays differed between the models. Thus, as new methylation microarrays are developed and older models are discontinued, existing epigenetic clocks might become obsolete. Here, we explored the effects of the changes introduced in the new DNA methylation array from Illumina (EPICv2) on existing epigenetic clocks.
Methods
We compiled a whole-blood DNA methylation dataset of 10835 samples to test the performance of four epigenetic clocks on the probe set of the EPICv2 array. We then used the same data to train a new epigenetic age prediction model compatible across the 450k, EPICv1 and EPICv2 microarrays. We compiled a validation dataset of 2095 samples to compare our model with a state-of-the-art epigenetic clock. We used a dataset of cancer survivors who had undergone different types of therapy and a dataset of breast cancer patients and controls to test the ability of our model to detect alterations in epigenetic age acceleration.
Results
We found that the results of the four epigenetic clocks tested are significantly distorted by the absence of specific probes in the EPICv2 microarray, causing an average drift of up to 25 years. We developed an epigenetic age prediction model compatible with the 450k, EPICv1 and EPICv2 microarrays. Our model produced highly accurate chronological age predictions that were comparable to those of a state-of-the-art epiclock. This finding reproduced previous results showing increased epigenetic age acceleration in cancer patients and in survivors who had been treated with radiation therapy.
Conclusion
Our work demonstrated that existing epigenetic clocks need to be updated to be applicable to data generated with the new EPICv2 microarray, which has phased out the 450k and EPICv1 models. To overcome this technical hurdle, we developed a new model that translates the capabilities of state-of-the-art epigenetic clocks to the new EPICv2 platform and is cross-compatible with the 450k and EPICv1 microarrays.
Examining parenting behaviors as predictors of fine-grained dimensions of externalizing psychopathology in youth
Authors: Karlovich Ashley R. , Evans Spencer C. 
Published: July 2024

Abstract

Although the associations between specific dimensions of parenting behaviors (e.g., inconsistent discipline, poor monitoring/supervision, positive parenting) and youth externalizing problems are well-studied, externalizing constructs have often been measured broadly, imprecisely, or inconsistently. To clarify this picture, we examined the links between parenting behaviors and fine-grained dimensions of externalizing-spectrum problems. Caregiver-report survey data were collected for 576 youths ages 6-14. Path models revealed that poor monitoring/supervision and inconsistent discipline emerged as robust, independent predictors of all seven types of externalizing variables examined; however, the effects of positive parenting were attenuated to non-significance in combined models. These results held when controlling for, and were not moderated by, demographic variables (parent/child age/gender). Findings underscore the importance of parents’ inconsistent discipline and poor monitoring/supervision in accounting for child externalizing problems, while also revealing the consistency of associations with various externalizing-spectrum problems (e.g., irritability, aggression, ODD, ADHD). Replication using multiple methods and informants is needed.
Plasmodium falciparum infections and Soil Transmitted Helminthes correlates with Anemia in Pregnancy: Cross-Sectional Study in Kwale County
Authors: Nyamu Msc Gibson Waweru , Kaplich Bsc Raphael Tuitoek , Odhiambo Msc Frendrick Ouma , King'oo Bsc Jacintah Mueni , Wigina Msc Ronald Nyarambe 
Published: July 2024

Abstract

Background
Prevalence of Anemia in Pregnancy (AiP) in Kenya ranges from 40.6–69.1%. We estimated the prevalence of AiP and correlated Plasmodium falciparum infections and Soil transmitted Helminthes (STHs) infections among the predictors AiP among pregnant women attending antenatal care (ANC) visits.
Methods
We performed a cross-sectional study among pregnant women attending ANC at Msambweni Hospital, between January and March 2024. Data was collected and analyzed in Epi Info 7. Descriptive statistics were calculated and we compared pregnant women with AiP with those without the condition. Crude Odds Ratios (COR) and 95% confidence intervals (CI) were calculated to identify factors associated with AiP.
Results
A total of 396 pregnant women were included in the study. The mean age was 27.4 years ± 6.5 years. Proportion of anemia was reported in 201 (50.76%) participants, and the mean Hb was 10.87 mg/dl (± 1.46 mg/dl); 108 (53.73%). The malaria positivity rate among them was 13.38% (53/396), and for STHs was 24/396 (6.06%) (95% CI; 4.11–8.86). Pregnant women with Plasmodium falciparum infections were 2.5 times more likely to experience anemia compared to those without malaria parasites (COR; 2.5, 95% CI: 1.35–4.71). Pregnant women residing in rural areas were 4.1 times more likely to have anemia than those living in urban areas (COR; 4.1, 95% CI: 2.64–6.39). Furthermore, pregnant women with STH infections were 1.7 times more likely to experience anemia compared to those without STH infections (COR; 1.7, 95% CI: 0.71–3.90).
Conclusion
The prevalence of anemia among pregnant women attending Msambweni County Referral Hospital remains high, associated with Plasmodium falciparum infections, STH infections, and women residing rural areas. Tailored interventions measures should be put in place to reverse the trend.