bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on the Construction of a Water saving Society in Guizhou
Authors: Yang Yingming , Ning Baoquan , Shan Zhenpei , Yang Meilan 
Published: August 2024

Abstract

In order to implement national management of water resources and strive to comprehensively promote the construction of a water-saving society, this study chose the construction of a water-saving society in Guizhou Province as the research object, investigating the impact of water resources, economic conditions, and water-saving potential on the water-saving society in Guizhou region. Firstly, the Analytic Hierarchy Process (AHP) is used to calculate the weights of water resources, socio-economic factors, and water-saving potential. Secondly, the entropy weight method is applied to calculate the weights of water resources, economy, and water-saving potential in Guizhou Province, and the behavioral TOPSIS method is used to calculate the proximity and conduct sensitivity analysis. Finally, the level of water-saving society construction in Guizhou Province was calculated based on AHP and entropy weight method. The research results indicate that the water-saving level in Guiyang city is level three, while the water-saving level in other areas of Guizhou is level four. Guizhou Province has made certain achievements in the construction of a water-saving society, but due to the influence of its karst topography, the construction of a water-saving society has been greatly hindered, resulting in a relatively low overall level. Due to its location in the subtropical region of southern China, Guizhou has an annual rainfall higher than the national average. Although its water resources are relatively good, its economy is relatively weak, and its water-saving potential is enormous. With the continuous development of the economy and the continuous growth of per capita income, it is recommended to prioritize the construction of a water-saving society in urban sustainable development, laying the foundation for the economic development of Guizhou Province and providing reference for the construction of a water-saving society in the region.
M1 macrophage-derived exosomal miRNA-155-5p induced disease inflammatory microglia by targeting SOCS1/JAK1/STAT1 signal pathway in APP/PS1 transgenic mice
Authors: Yan Aijuan , Liu Ying , Yang Fuxia , Lv Mingxuan , Wang Dan , Wang Liping , Shu Jun , Jiao Yuqiong , Xu Ziwei , Zhang Li , Guo Han , Wei Wenshi 
Published: August 2024

Abstract

Background Neuroinflammation represents a prevalent pathological characteristic of Alzheimer’s disease (AD). Research indicates that peripheral immune cells, such as activated macrophages, contribute to the pathogenesis of neurodegenerative diseases by triggering neuroinflammatory processes. This suggests that the interaction between immune cells of the peripheral and central nervous systems (CNS) plays a pivotal role in the advancement of AD. Exosomes are recognized as vital mediators facilitating communication between peripheral and CNS immune cells. However, the specific role of peripherally activated macrophages in accelerating AD progression via exosomal pathways remains unresolved. Methods The study employed in vivo and in vitro assays to identify the role of exosomes derived from activated macrophages (M1 macrophages). Methods such as single-cell sequencing, RT-PCR, flow cytometry, western blot, and immunofluorescence were utilized to elucidate how exosomes regulate the interaction between M1 macrophages and CNS immune cells. Results The experimental results initially showed that exosomes derived from M1 macrophages (M1-EXO) were primarily engulfed by microglia both in vitro and in vivo. Subsequent validation indicated that M1-EXO induces the formation of disease inflammatory microglia (DIM), accelerates Aβ accumulation, and contributes to cognitive impairment. Moreover, it was confirmed that exosomal miR-155-5p from M1 macrophages induced DIM formation by reducing SOCS1 expression and activating phosphorylation of the JAK1/STAT1 signaling pathway. Conclusion These findings reveal a communication mechanism between peripheral M1 macrophages and central microglia in the metastatic microenvironment mediated by exosomes, affecting the pathological progression of AD. The study also provides theoretical evidence demonstrating a potential mechanism by which M1 macrophages accelerate the progression of AD.
Hypoxia-induced SZT2-AS1 is required for HIF-1 heterodimer formation and histone trimethylation in HCC cells under hypoxic microenvironment
Authors: Wang Yufeng , Liu Runkun , Guo Yixian , Yin Guozhi , Tuo Hang , Zhu Yifeng , Yang Wei , Liu Qingguang 
Published: August 2024

Abstract

Hypoxic microenvironment plays a critical role in solid tumor growth, metastasis and angiogenesis. Hypoxia-inducible factors (HIFs), which are canonical transcription factors in response to hypoxia, are stabilized under hypoxia and they coordinate the process of hypoxia-induced gene expression leading to cancer progression. Increasing evidence has indicated that long noncoding RNAs (lncRNAs) which are closely associated with cancer play crucial roles in hypoxia-mediated HCC progression, while the mechanisms are largely unknown. Here, we identified a novel lncRNA SZT2-AS1 in HCC, which was induced by hypoxia in a HIF-1-dependent manner and promoted HCC growth, metastasis and angiogenesis. The clinical data indicated that SZT2-AS1 level was substantially upregulated in HCC and significantly associated with poor clinical outcomes, and acted as an independent prognostic predictor. Mechanistically, SZT2-AS1, in turn, recruited HIF-1α and HIF-1β to form the HIF-1 heterodimer. And SZT2-AS1 was required for the occupancy of HIF-1 to hypoxia response elements (HREs) and HIF target gene transcription. In addition, SZT2-AS1 was required for hypoxia-induced histone trimethylation (H3K4me3 and H3K36me3) at HREs. Through recruiting methyltransferase SMYD2, SZT2-AS1 promoted trimethylation modification of H3K4 and H3K36 in HCC cells. Taken together, our results uncovered a lncRNA-involved positive feedback mechanism under hypoxia and established the clinical value of SZT2-AS1 in prognosis and potential therapeutic strategy for HCC.
Significance: LncRNA SZT2-AS1 involves in a positive feedback mechanism under hypoxia, which provides a therapeutic strategy for HCC.
CMT-YARN: An Efficient YARN Security Framework based on an Improved Merkle Tree
Authors: Liu Peihao , Luo Daojie , Liu Jiahua , Deng Junyi , Bu Dengli , Wang Huan , Yan Junjie 
Published: August 2024

Abstract

Hadoop is one of the most popular platforms for distributed big data processing, and YARN is at the core of Hadoop 2.0. In the process of data processing, the possibility exists that malicious nodes might compromise the results, sharing incorrect outputs on the public cloud. To address this issue, this paper introduces an efficient YARN security framework, termed CMT-YARN, which incorporates an enhanced convolutional Merkle Tree to ensure the reliability of task execution results. Within a hybrid cloud environment, this framework utilizes the improved CMHT verification technique to conduct dual verification of intermediate and final results, thereby ensuring data integrity and reliability throughout the execution process. Compared to conventional MHT, CMHT reduces additional computational overhead by more than 37% during verification processes. Qualitative and quantitative analyses indicate that with a data sampling rate of 6.8%, CMT-YARN can ensure that the number of malicious acts undetected by the system does not exceed 5; when the sampling rate exceeds 26.9%, the framework can guarantee the detection of all malicious activities. Experimental results on a real Hadoop cluster demonstrate that CMT-YARN significantly enhances computational and storage performance compared to traditional solutions.
A study on the correlation between microRNA and liver cirrhosis
Authors: Yuan Jianxu , Zhou Dalin , Yu Shengjie 
Published: August 2024

Abstract

Background: MicroRNAs (miRNAs) occupy a pivotal position in the intricate machinery of gene regulation. However, the potential causal linkage between miRNA and cirrhosis remains unexplored. This study attempts to investigate this causal relationship in depth through various methods such as Mendelian randomization (MR).
Methods: This study uncovered the causal relationship between miRNA and cirrhosis through the utilization of pertinent data. Employing a two-sample MR design, the investigation was conducted utilizing five different methods: the inverse variance weighted (IVW) method, the MR Egger method, the weighted median method, the simple mode method, and the weighted mode method. To ensure the robustness of our findings, we conducted a thorough sensitivity analysis encompassing Cochran's Q test, the MR Egger intercept test, MR-PRESSO, and leave-one-out analysis. Furthermore, to strengthen the validation of the causal effects, we performed meta-analysis on data gathered from diverse platforms. Ultimately, we delved into potential mechanisms of action by predicting the target genes of corresponding miRNAs and analyzing their functional enrichment.
Results: A total of seven miRNAs were identified as being associated with the risk of cirrhosis. Notably, the instrumental variables (IVs) employed in this study exhibited no significant heterogeneity or horizontal pleiotropy. The results of the meta-analysis further confirmed that hsa-miR-27b-3p was a risk factor for liver cirrhosis, while hsa-miR-1303 had a protective effect. In addition, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that the target genes corresponding to hsa-miR-27b-3p were significantly enriched in pathways such as cell cycle, oxidative stress, and cell fibrosis, while the target genes corresponding to hsa-miR-1303 were mainly enriched in pathways such as amino acid metabolism.
Conclusion: Our research findings not only identified potential miRNA biomarkers that could significantly contribute to the diagnosis and treatment of cirrhosis, but also paved new avenues for future study in this domain.
Influence of Nanoselenium Supplementation and Interval Training on Hepatic MMP-13 and TGF-β Gene Expression in Dexamethasone-treated Rats
Authors: Gilani Sara Mousavi , Malayeri Shahin Riyahi , Hosseini Masoume , Fanaei Hamed 
Published: August 2024

Abstract

Purpose:
Recent research suggests that combining nanoselenium supplements with exercise enhances immune function. This study investigates Influence of Nanoselenium Supplementation and Interval Training on Hepatic MMP-13 and TGF-β Gene Expression in Dexamethasone-treated Rats.
Methods:
Forty eight-week-old rats were randomly assigned to five groups:1-Control group (healthy rats). 2-Dexamethasone-induced control group. 3-Dexamethasone + nanoselenium supplement group. 4-Dexamethasone + interval exercise group. 5-Dexamethasone + nanoselenium supplement + interval exercise group.Interval training involved running repetitions on a treadmill with increasing intensity and duration over four weeks. Nanoselenium supplements were orally administered every other day.
Results:
Finding demonstrated a significant increase in MMP13 expression in Dexa, NaSe, Trng and Trng+NaSe groups than Control group (p<0.05). NaSe, Trng and Trng+NaSe groups exhibited significantly lower MMP13 expression compared to the Dexa group (p<0.0001). The combination of training with nanoselenium resulted in a significant reduction in MMP13 expression compared to training alone (p<0.05).The Dexa group exhibited a significant increase in TGF-β levels, with an expression more than twofold higher than the control group (p < 0.01). TGF-β expression was significantly lower in the NaSe (p < 0.0001), Trng (p < 0.05), and Trng+NaSe (p < 0.0001) groups compared to the Dexa group. In addition, TGF-β expression in the Trng+NaSe group was significantly lower than that in the Trng group (p < 0.05).
Conclusion:
Intermittent exercise and nanoselenium supplementation enhance the body's antioxidant system, leading to improved immune function and the mitigation of the negative effects of dexamethasone on MMP-13 and TGF-β gene expression.
The Impact of Shame on the Dual Harm in Adolescents: The Role of Cognitive Flexibility
Authors: Yan PengYun , Jiang ZhiXiong , Wang YaFan , Zhang Ao , Wang LongFei , Zhang GuoLi 
Published: August 2024

Abstract

Dual harm is a grave public health concern within the adolescent population, linked to mental disorders and extreme behaviors such as suicide. However, the psychological mechanisms underlying dual harm in adolescents are poorly understood. This study aims to investigate the role of shame in adolescent dual harm, as well as the mitigating effects of cognitive flexibility, based on the cognitive-emotional model of dual harm. This study employs two sequential experiments. Experiment 1 manipulates subjects' shame using a shame induction task, measuring dual harm with scores from the Tabasco Sauce Paradigm and Cold Pressor Test. The results reveal that compared to the control group, the intervention group exhibits higher levels of dual harm behaviors. Experiment 2 builds upon this foundation, employing the Wisconsin Card Sorting Test to measure cognitive flexibility. The results replicate those of Experiment 1 and further demonstrate that reduced cognitive flexibility exacerbates dual harm. Shame is considered to trigger dual harm, which cognitive flexibility can mitigate.
Empirical models for non-destructive evaluation of in-situ compressive strength of structural concrete with the objective of encompassing global uncertainty factors
Authors: Debroy Sudipta , Sil Arjun 
Published: August 2024

Abstract

The compressive strength of concrete, although, conventionally, used to be determined either by destructive tests of cubes cast in-situ, or from concrete cores extracted from an existing structure, can be easily estimated at present with the help of empirical correlations with inputs from non-destructive test results of Rebound Hammer and Ultrasonic Pulse Velocity. The main contribution of this paper lies in the proposition of empirical correlations for compressive strength determination from a global uncertainty perspective, not considered previously to the best of the authors’ knowledge. To fulfil this objective, correlation equations published worldwide for both univariate and bivariate relationships have been collected and the most suitable ones selected based on their statistical reliability. Further, linear and non-linear regression analysis have been performed on justifiably chosen datasets for the predictor variables. Finally, Linear, Polynomial, Power and Exponential models are developed with appreciable metrics outcomes for all three types of correlations and the best three models proposed after successful validation on country-wise in-situ data accumulated from various literatures.
Synthesis, thermal, physical, structural, optical, and elastic characteristics of new class of glasses based on the Sb2O3-K2O-B2O3 system
Authors: hamzaoui majda , Beghdadi lina , guesmia nesrine , Lebullenger Ronan , Bouras Omar , soltani mohamed toufik 
Published: August 2024

Abstract

A new series of glasses based on the system (80-x) Sb2O3-20K2O-xB2O3 where (0 ≤ x ≤ 40 mol. %) was prepared using melt-quenching process. XRD characterization is used to improve the non cristallinity nature of the glass samples. The different structural characteristics, including molar volume (Vm), density (ρ), d (B−B) distance between two boron atoms, oxygen content by oxygen molar volume (VO), packing density (OPD) and the free volume (Vf) were obtained to properly verify the compactness of the SKB glass network characterized by more links. In addition to the thermal, optical, elastic, structural and physical factors, which were examined, the vitreous nature of SKB glasses was verified according to the DSC curves. Structural analysis were performed using ATR spectroscopy to determine the fraction of four coordinated boron atoms as well as the presence of several functional groups in the glass samples. All these changes support the modification of the glass structure from BO3 to BO4. The study carried out using ultrasonic technology has been done to investigate the structural role of B2O3 in SKB glasses. The different moduli of elasticity (E, K, G, L, and υ) as well as the Debye temperature and Makishima Mackenzie’s theory can be explained by the glass structure’s compactness.
Perspectives of Patients with Type 1 and Type 2 diabetes on barriers to diabetes care: A qualitative study
Authors: Shrestha Sweta , Sapkota Sujata , Acharya Khagendra , Chaulagain Sabin , Sayami Matina , Dahal Abhinav , Shakya Rajani , Karmacharya Biraj Man 
Published: August 2024

Abstract

Background
Diabetes care incorporates multiple integrated elements like self-care practices, patient education and awareness, societal support, equitable access to healthcare facilities and trained healthcare professionals, commitment from the diabetes associations and government policies. There is a dearth of research viewing into the barriers experienced by both People with Type 1 diabetes (PwT1D) and People with Type 2 diabetes (PwT2D) in accessing the holistic elements of diabetes care. This study thus aims to explore the perspectives of PwT1D and PwT2D towards barriers in receiving diabetes care services in urban and rural areas in Nepal.
Method
This study uses a qualitative research method where an in-depth interview of 23 participants on insulin was conducted using a semi-structured questionnaire. This included 15 PwT1D and 8 PwT2D, residing in the capital and rural areas and attending the hospitals and clinic in the urban and semi-urban regions in Nepal. The interviews were transcribed verbatim and thematically analyzed.
Results
Seven themes emerged from the study representing key barriers from patient’s perspective. These were: Theme 1) Diabetes stigma, Theme 2) Non-adherence to insulin and Self-Monitoring of Blood Glucose (SMBG), Theme 3) Lack of availability of healthcare professionals and other healthcare facilities, Theme 4) Dissatisfaction with healthcare services, Theme 5) Preference of alternative treatment strategies, Theme 6) Limitations of health insurance and Theme 7) Limited role of national diabetes organizations.
Conclusion
There is a need in raising awareness among general public especially on Type 1 Diabetes to address the issue of diabetes stigma. An effort in implementation of policies supporting diabetes care and refinement of National Health Insurance Scheme is equally essential. Similarly, strengthening of Health Care System by ensuring availability of insulin, laboratory facilities and trained healthcare professionals in rural areas should be focused to address the inequity in access to healthcare in rural and urban sectors.
Heat Transfer and Lifetime Estimation of High-Power Light Emitting Diodes (HPLED) Using Drop Shape Pin Fin Heat Sink Under Natural Convection
Authors: Deshmukh Ram Zampat , Raibhole V. N. 
Published: August 2024

Abstract

High-Power Light Emitting Diodes (HPLEDs) are a leading example of modern lighting technology and are praised for being more efficient than traditional light source’s. This study explores the complex relationship between HPLED service life, junction temperature (Tj), and heat dissipation through drop-shaped pin fins type heat sink attached to HPLED. Four different power inputs 50, 100, 150, and 200W were analysed using three different vertical pin fin spacings (Sv = 25, 50, and 75 mm). A data acquisition system was created to measure temperature, current, LED light intensity (Lux), and voltage values using sensors. These values were then used as the best possible reference values for a well-known Arrhenius equation model to predict the lifetime of the device. The results shows, as power input levels rise, Tj also increases, which reduces the life of HPLEDs. There is a distinct inverse relationship between device lifetime and Tj that exhibits a nonlinear exponential decay pattern. For 200 and 50 W power input, respectively, the maximum junction temperature of the HPLED attaching drop-shaped pin fin heat sink was found to be 134.78°C and the minimum Tj was found to be 60.13°C. The drop-shaped fin pin heat sink with a 75 mm fin spacing was found to have a maximum heat transfer coefficient of 9.81 W/m2K. With a 200 W power dissipation and a junction temperature (Tj) of 134.78°C, the HPLED had a short expected operational life of 1780.2 hours. On the other hand, a projected lifetime of 3996.30 hours is anticipated at a higher temperature of Tj=112.18°C.
Research on Cortical Inhibition Response in Migraine: An Go/No-Go Study
Authors: Ning Jinru , Wang Yan , Li Huanyu , Zhang Huifei , Sun Zhiyuan , Zhang Yuan , Lv Yudan 
Published: August 2024

Abstract

Introduction:
Migraine is a common chronic primary headache. Cognitive dysfunction has been found in patients with migraine after repetitive attacks. We used aspecific task paradigm called Go/No-Go to explore cognitive dysfunction, especially cortical inhibition.
Methods:
Our study included 30 participants with migraine and 30 healthy controls. We used the Go/No-Go task to analyze different Event related potential （ERP） components,such as latency or amplitude,to explore whether differences couldbe found. The two-tailed Pearson’s R correlation was performed between the clinical characteristics of patients with migraine,such as education, clinical course, duration, frequency, pain intensity, and ERP data. To test thedegree of independence between the clinical characteristics and ERP data, we performed multiple regression.
Results:
At the electrophysiological level, participants with migraine had longer latencies and larger amplitudes of N2 or P3 than the control group under the Go or No-Go conditions. In addition, significant two-tailed Pearson’s R correlations werefound in different areas. In particular, clinical characteristics were correlated with No-Go-N2 latency or amplitude in the frontal, central, or temporal area and correlated with No-Go-P3 latency or amplitude in the midline area of the frontal-central-parietal lobe. Finally, linear regression analysis revealed severalindependent factors that affected the N2 or P3 components in specific cortical areas.
Conclusion:
Our study revealed that repetitive attacks may influence response inhibition in patients with migraine. Abnormal changes in the inhibition process or inhibition supervision have been presented and interpreted by N2/P3 components under the Go/No-Go condition. Additionally, correlations were found between sex, education, pain, and N2/P3 components located in different regions. On the basis of our results, we found that patients with migraine have poor executive function, delayed response, abnormal response inhibition, and abnormal inhibitory monitoring, meriting the design and execution of future clinical studies.