bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathological analysis of lymph nodes in anterior prostatic fat excised at robot-assisted radical prostatectomy
Authors: Aning J J , Thurairaja R , Gillatt D A , Koupparis A J , Rowe E W , Oxley J 
Published: July 2014

AimsTo assess the lymph node content of anterior prostatic fat (APF) sent routinely at robot-assisted laparoscopic radical prostatectomy (RALP) and the incidence of positive nodes in the extended pelvic lymph node dissection.MethodsBetween September 2008 and April 2012, APF excised from 282 patients who underwent RALP was sent for pathological analysis. This tissue was completely embedded and lymph nodes counted.ResultsIn total, 49/282 (17%) patients had lymph nodes in the APF, median lymph node yield in this tissue was 1 (range 1–5). In four patients, the lymph nodes contained metastatic deposits. These patients did not have positive nodes elsewhere in the extended lymph node dissection.ConclusionsAPF contains lymph nodes in 1 in 6 patients and infrequently these may be malignant. APF should always be removed at radical prostatectomy. APF should be routinely sent for pathological analysis.
Bilateral inferior petrosal sinus sampling using desmopressin or corticotropic-releasing hormone: a single-center experience
Authors: Deipolyi Amy R , Alexander Bailin , Rho Jun , Hirsch Joshua A , Oklu Rahmi 
Published: July 2014

BackgroundBilateral inferior petrosal sinus sampling (BIPSS) following corticotropic-releasing hormone (CRH) stimulation is the current gold standard technique in the diagnosis of Cushing disease. However, as a result of CRH shortage, desmopressin (DDAVP) has been used instead for BIPSS. We present the experience of a single tertiary care center using the modified BIPSS protocol and compare the results obtained with DDAVP with those obtained with CRH.MethodsUsing the radiology department's electronic database, BIPSS procedures performed at our institution using DDAVP and CRH were identified. Electronic medical records and imaging studies were reviewed and the clinical history, demographic data, endocrine test results, complications of BIPSS, and patient outcomes were recorded. BIPSS data were analyzed for centralization and lateralization of pituitary adrenocorticotropic hormone (ACTH) source. We identified 20 BIPSS cases (16 women, mean age 38 years) performed using DDAVP between 2012 and 2013.ResultsThe 20 cases demonstrated conventional inferior petrosal sinus anatomy and were successfully cannulated bilaterally. Of these, 18 met the criteria for both centralization and lateralization. A total of 18 patients underwent trans-sphenoidal tumor resection; one patient was lost to follow-up and one is still being followed. There were no complications resulting from the use of DDAVP, specifically no thromboembolic events. Calculated sensitivity for BIPSS with DDAVP was 94.5%. There was also no significant difference in the biochemical results produced by BIPSS using either DDAVP or CRH. All 18 patients demonstrated an ACTH-secreting adenoma on pathology review.ConclusionsDDAVP is a safe alternative to CRH, producing comparable diagnostic results.
Classification of cavernous internal carotid artery tortuosity: a predictor of procedural complexity in Pipeline embolization
Authors: Lin Li-Mei , Colby Geoffrey P , Jiang Bowen , Uwandu Chiedozie , Huang Judy , Tamargo Rafael J , Coon Alexander L 
Published: July 2014

BackgroundFlow diverters are increasingly used for the treatment of intracranial aneurysms. Understanding cavernous internal carotid artery (cICA) tortuosity may help to predict procedural complexities of deploying flow diverters.MethodsPipeline embolization device (PED) neurointerventions for ICA aneurysms proximal to the ICA termination were reviewed. Cavernous ICA tortuosity was measured as a ratio D/AP, where D=height difference of the anterior and posterior genus, AP=sum of the angles of the anterior (A) and posterior (P) genus. Four types of cICA tortuosity were proposed. An analysis of variance regression and Fisher's exact test were performed to analyze differences among the types.ResultsCavernous ICA tortuosity was categorized into minimal (type I, n=28), moderate (type II–III, n=29), and severe (type IV, n=26). The groups were comparable for patient age (mean ± SEM years, type I: 55.6±10.4, II–III: 56.4±14.4, IV: 55±12.8) and aneurysm size (mean±SEM mm, type I: 6.25±3.5, II–III: 7.6±4.9, IV: 9.11±4.9). Analysis of variance demonstrated significant differences in procedural fluoroscopy time (mean ± SEM min, type I: 29.8±8.4, II–III: 44.9±34.1, IV: 52.6±17.2, p<0.005) and mean ± SEM D/AP (type I: 0.008±0.0008, II–III: 0.141±0.07, IV: 0.482±0.365, p<0.0001). Procedural complexity was also statistically significant (p<0.005) with 4%, 28%, and 35% of cases in types I, II–III, and IV, respectively, requiring intraprocedural PED removal or balloon post-processing of the implanted PED.ConclusionsWe propose a classification system for cICA tortuosity based on measurements of the anterior and posterior genu geometry. This classification correlates strongly with markers of PED procedural complexity and may be helpful in pre-procedure prognostication.
Prevalence, risk factors and vaccination efficacy of contagious ovine ecthyma (orf) in England
Authors: Onyango J. , Mata F. , McCormick W. , Chapman S. 
Published: July 2014

Orf is a viral disease found in English sheep flocks which can cause economic losses. It is a zoonosis with little epidemiological research available in the UK. In 2012, 3000 questionnaires were sent to English sheep farms in order to investigate the prevalence of orf, determine vaccination efficacy and to identify some of the potential risk factors. The usable response rate was 25.4 per cent. The usable farms (N=762 in the years 2011 and 2012) were used to model the percentage of animals affected on the farm, and the probability of a farm being found with the disease. The disease prevalence (DP) was standardised for the year and calculated as 1.88 per cent for ewes and 19.53 per cent for lambs. The disease risk ratio (RR) for the use of the vaccine was calculated as 2.04 for ewes and 0.75 for lambs, and therefore, the study found that lamb vaccination was beneficial (RR <1). Weed infestation and an increased number of orphan lambs were associated with increased cases of orf. We conclude that the DP in ewes and lambs affect each other, though the impact is higher for lambs in the presence of increasing prevalence in ewes. A short lambing season lowers the probability of a farm experiencing cases of orf. Vaccination was effective in lambs but not in ewes, though lambs benefitted when ewes were vaccinated (reduced orf prevalence in lambs born from vaccinated ewes), probably because any unvaccinated ewes may have been carriers that could spread the virus to the new‐born lambs.
Report on the sixth workshop on exploiting semantic annotations in information retrieval (ESAIR'13)
Authors: Bennett Paul N. , Gabrilovich Evgeniy , Kamps Jaap , Karlgren Jussi 
Published: July 2014

There is an increasing amount of structure on the web as a result of modern web languages, user tagging and annotation, emerging robust NLP tools, and an ever growing volume of linked data. These meaningful, semantic, annotations hold the promise to significantly enhance information access, by enhancing the depth of analysis of today's systems. Currently, we have only started exploring the possibilities and only begin to understand how these valuable semantic cues can be put to fruitful use.
ESAIR'13 focuses on two of the most challenging aspects to address in the coming years. First, there is a need to include the currently emerging knowledge resources (such as DBpedia, Freebase) as underlying semantic model giving access to an unprecedented scope and detail of factual information. Second, there is a need to include annotations beyond the topical dimension (think of sentiment, reading level, prerequisite level, etc) that contain vital cues for matching the specific needs and profile of the searcher at hand.
There was a strong feeling that we made substantial progress. Specifically, the discussion contributed to our understanding of the way forward. First, emerging large scale knowledge bases form a crucial component for semantic search, providing a unified framework with zillions of entities and relations. Second, in addition to low level factual annotation, non-topical annotation of larger chunks of text can provide powerful cues on the expertise of the search and (un)suitability of information. Third, novel user interfaces are key to unleash powerful structured querying enabled by semantic annotation|the potential of rich document annotations can only be realized if matched by more articulate queries exploiting these powerful retrieval cues|and a more dynamic approach is emerging by exploiting new forms of query autosuggest.
A qualitative investigation of adults’ perceived benefits, barriers and strategies for consuming milk and milk products
Authors: Jung Mary E , Mistry Chetan , Bourne Jessica E , Perrier Marie-Josee , Martin Ginis Kathleen A , Latimer-Cheung Amy E 
Published: July 2014

Objective: Milk and milk products provide important nutrients and have been associated with numerous health benefits in addition to bone health, including a healthy weight and a reduction of risk for certain conditions such as type 2 diabetes, hypertension, cardiovascular disease and colorectal cancer. Nonetheless, consumption of milk and milk products has declined over the past two decades. A qualitative investigation of men’s and women’s outcome expectancies for, and facilitators and barriers to, consuming milk and milk products is an essential first step for the creation of theory-based messages for the consumption of milk and milk products. Design: Qualitative group interview study. Setting: Research was conducted at community centres in Kelowna, British Columbia, Canada. Method: We undertook eight in-depth qualitative group interviews. Separate groups were conducted for men ( n = 20, Mage = 42 ± 6) and women ( n = 20, Mage = 38 ± 7) and adequate (≥2 servings/day) and under-consumers (<2 servings/day). The interview schedule, grounded in social cognitive theory, included questions probing participant’s perceptions of milk and milk products and strategies for meeting dietary recommendations for milk product consumption. Data were analysed using hierarchical content analysis. Results: Perception of contamination of milk and milk products was one of the most common barriers. Consuming milk and milk products as part of a routine and making plans to consume milk and combining milk and milk products with other foods emerged as common strategies from ensuring adequate consumption. Within these themes, gender differences were apparent. Conclusion: Messages promoting milk and milk product consumption should target consumers’ beliefs about the benefits of milk products and provide strategies for increasing their consumption.
Langerhans cell histiocytosis: 23 years’ paediatric experience highlights severe long-term sequelae
Authors: Martin Allison , Macmillan Susan , Murphy Dermot , Carachi Robert 
Published: July 2014

Purpose To review the presentation and outcome of patients with Langerhans cell histiocytosis attending The Royal Hospital for Sick Children, Glasgow over a 23-year period. Method Thirty-one children were diagnosed with Langerhans cell histiocytosis between January 1990 and December 2012. Retrospective information from medical records was gathered on age at diagnosis, presenting symptoms, classification of disease, treatment and long-term outcome. Results There were 17 boys and 14 girls; median age at diagnosis 2 years 9 months (interquartile range: 1 year 6 months to 4 years 4 months). Eleven were below 2 years and two were below 6 months of age at diagnosis. Eighteen (58%) children had single system disease of which four were multifocal; 13 (42%) had multisystem disease. Seventeen children improved with conservative treatment. Fourteen required steroids and dual agent chemotherapy; three required further chemotherapy. One child died. Two children had successfully treated relapses. Ten developed diabetes insipidus, seven were growth hormone deficient, two suffered from hypothyroidism and one panhypopituitarism. Median follow-up of the cohort was 8 years 10 months (interquartile range: 5 years 5 months to 12 years 7 months). Conclusion Langerhans cell histiocytosis is a rare disease in infants and young children, with a variable course ranging from self-limiting to life threatening. In very young children (under 2 years of age), multisystem disease is more common, requiring intensive chemotherapy and lifelong follow-up. Lasting sequelae were identified in over a third of patients, including endocrine dysfunction, hearing difficulties, neurological and psychological problems.
Liver abscess in the tropics: an experience from Jammu
Authors: Naveed Shah , Gupta VB , Kapoor Maria , Quari Hasina , Altaf Asma , Para Maha 
Published: July 2014

Objective To study the various types of liver abscesses. This prospective study was conducted over a period of one year, from November 2011 to October 2012, at the Department of General Surgery in Acharya Shri Chander College of Medical Sciences and Hospital Sidhra, Jammu. Materials and methods The patients in this study were admitted from the emergency wing, and from indoor and outdoor departments of surgery and medicine over a period of one year (November 2011 to October 2012) to the Department of General Surgery in Acharya Shri Chander College of Medical Sciences and Hospital Sidhra, Jammu. Patients of all age groups and both genders who presented with clinical suspicion of liver abscess, or had already been diagnosed, were included in the study. A definitive diagnosis of liver abscess was made based on compatible clinical features, ultrasonography and aspiration or drainage of pus. Diagnostic criteria for the various types of abscesses were as follows: Amoebic abscess: demonstration of Entamoeba histolytica trophozoites in aspirated pus. Pyogenic abscess: positive cultures of blood or aspirated pus. If both of the above sets of criteria were satisfied, the abscess was considered to be of mixed aetiology. Tuberculous abscess was diagnosed by identifying acid-fast bacilli in aspirated material and polymerase chain reaction. The abscess was classified as indeterminate if none of the above criteria were satisfied. Results The majority of patients in our study had amoebic liver abscesses (73.33%). Escherichia coli and Klebsiella were the most common organisms cultured from the pyogenic abscesses. The majority of patients with amoebic liver abscesses were treated with drug therapy alone, whereas all pyogenic liver abscesses required some form of drainage.
The effect of footplate neuromuscular electrical stimulation on venous and arterial haemodynamics
Authors: Varatharajan Lavanya , Williams Katherine , Moore Hayley , Davies Alun Huw 
Published: July 2014

Objective This pilot study aims to determine the effect of the Revitive™ footplate neuromuscular electrical stimulation device on venous and arterial haemodynamic changes in healthy individuals. Method The blood flow (cc/min) and time averaged mean velocity (cm/s) of the superficial femoral vein and artery were measured using ultrasound at baseline, 15 min during, and immediately after cessation of the 30 min stimulation cycle. Data were analysed using the Wilcoxon matched-pairs signed rank test. Results Venous and arterial duplex ultrasound haemodynamic measurements were taken in 10 and 20 healthy volunteers, respectively. Mean age 38.7 (range 21–64), ankle brachial pressure index 0.9–1.0. At 15 min, there was a significant increase in venous median blood flow (88.3 cc/min, p = 0.014) and an increase in time averaged mean velocity (1.13 cm/s, p = 0.065) compared to baseline. Similarly, there was a significant increase in arterial median blood flow (38.7 cc/min, p < 0.0001) and time averaged mean velocity (2.21 cm/s, p = 0.0003) at 15 min compared to baseline. There was no significant difference in venous or arterial measurements compared to baseline after stimulation cessation. Conclusions Blood flow and time averaged mean velocity increased during neuromuscular electrical stimulation but returned to baseline once stimulation had stopped. By improving blood flow, neuromuscular electrical stimulation has the ability to enhance venous return, counteract venous stasis and improve limb arterial inflow.
Use of Erythropoiesis-Stimulating Agents in the Treatment of Anemia in Patients With Systolic Heart Failure
Authors: Lindquist Desirae E. , Cruz Jennifer L. , Brown Jamie N. 
Published: July 2014

Objective: To determine the efficacy and safety of erythropoiesis-stimulating agents (ESAs) for the treatment of anemia in patients with systolic heart failure. Data Sources: A search of MEDLINE (1946-January 2014) and EMBASE (1947-January 2014) was conducted using the search terms erythropoietin and systolic heart failure. In addition, bibliographies of relevant articles were reviewed for additional citations. Study Selection and Data Extraction: All English language randomized controlled trials evaluating clinical outcomes or adverse events when using ESAs in the setting of systolic heart failure were included. Data Synthesis: A total of 9 studies were reviewed. All studies examining hematological parameters found a statistically significant increase in hemoglobin levels with active treatment versus placebo. Of the 7 trials evaluating exercise tolerance or capacity, only 4 demonstrated statistically significant improvement in these measures in patients receiving ESAs, whereas the remainder showed no clinical benefit. Four studies examined quality-of-life measures. Although numerical improvements were observed in most trials, statistical significance was reached in only 2 trials. A nonsignificant trend for decreased mortality in patients treated with darbepoetin with a similar adverse event profile compared to placebo was shown in one study; however, the largest trial to date showed no benefit in all-cause mortality or heart failure-related hospitalizations with the use of ESAs. Additionally, a statistically significant increase in the number of cerebrovascular events and thrombotic events was found. Conclusion: There is inconclusive evidence to suggest that the use of ESAs in treating anemia in patients with heart failure is beneficial. Although ESAs demonstrated a clear ability for increasing hemoglobin levels, the data regarding clinical outcomes such as exercise parameters, quality of life, and hospitalizations are conflicting. In addition, a mortality benefit has not been shown; therefore, the potential for improved symptomatology must be weighed against the potential for adverse events.
Lamp spectrum and spatial brightness at photopic levels: Investigating prediction using S/P ratio and gamut area
Authors: Fotios S , Atli D , Cheal C , Hara N 
Published: July 2014

An experiment was carried out to investigate spatial brightness at photopic levels under lighting of different spectral power distributions. One aim was to replicate the experiment reported in 1990 by Berman et al. demonstrating that light with a higher scotopic / photopic (S/P) ratio would be perceived as brighter. In addition, a third SPD was included to investigate gamut area and two additional procedures were employed to provide concurrent validity of the findings. It was concluded that while lighting of higher S/P ratio was brighter, the S/P ratio alone was insufficient to predict spatial brightness. A metric for the chromatic contribution is also needed, this being provided by gamut area in the current work.
Fistula first, graft on arterialized vein second
Authors: Galzerano Giuseppe , Giubbolini Michele , Setacci Francesco , de Donato Gianmarco , Sirignano Pasqualino , Messina Gabriele , Cappelli Alessandro , Setacci Carlo 
Published: July 2014

Objectives Arterovenous grafts (AVGs) present a feasible solution for creating a vascular access in patients who are unsuitable for autogenous fistula (AVF). The aim of this study is to assess the prevention rate of vein stenosis, placing a graft on an arterialized vein (GAV) instead of an anastomized AVG in a native vein (GNV). Methods This was a cohort study conducted from January 2009 to November 2012. All consecutive patients who underwent AVG in our institution were included. All patients requiring a secondary intervention were also referred to our centre. Patients underwent ultrasound follow up at first and the every month. A Kaplan–Meier method was used; a Log-rank test was used to identify whether significant difference existed between GAV and GNV ( p < 0.05). Results Forty-six grafts were placed. Twenty patients had arterialized receiving veins (group A), while 26 patients received an AVG immediately because they lacked autogenous veins suitable for fistula (group B).The average follow-up period was 16.1 months (range 0–41). The group A 41 months-patency rate was 84.3%, while group B was 43.7% ( p = 0.06). Secondary patency was similar in the two groups. Conclusions Vein arterialization seems to prevent venous stenosis improving AVG-patency rate. More data are needed; however, the borderline p value encourages new studies.
The Boyd–McLeod procedure for tennis elbow: mid- to long-term results
Authors: Jeavons Richard , Berg Andrew J , Richards Ian , Bayliss Neil 
Published: July 2014

Background Tennis elbow is a common condition that usually responds to conservative measures. In refractory cases, surgical intervention is indicated. A plethora of surgical techniques have been described. We report the mid- to long-term outcomes of the Boyd–McLeod procedure for refractory tennis elbow. Methods A retrospective analysis and current review of patients that had undergone the Boyd–McLeod procedure over a 12-year period was undertaken. Demographics, time to discharge, length of follow-up and outcome scores were collected. Results Seventy patients underwent surgery. Mean time to discharge was 15.35 weeks, with 88% successful outcomes. Fifty-four patients were available for current follow-up at mean of 5.52 years (range 1.17 years to 11.49 years). Range of motion in all patients was unchanged. There were no revision procedures. Mean (SD) Mayo Elbow Performance Score was 90.85 (13.11), with 75.5% returning a good or excellent score and 24.5% a fair outcome. The mean (SD) Oxford Elbow Score was 44.04 (6.92); mean (SD) pain score was 89.5 (17.58); mean (SD) function score was 95.34 (9.59) and mean (SD) socio-psychological score was 91.50 (17.01). Overall, 83% of patients had an Oxford Elbow Score of 43 or greater, suggesting excellent outcome. Conclusions We show that the Boyd–McLeod procedure is an excellent option over both the short- and long-term for refractory tennis elbow.