bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells
Authors: Vazquez-Ortiz Guelaguetza , Chisholm Cristine , Xu Xiaoling , Lahusen Tyler J , Li Cuiling , Sakamuru Srilatha , Huang Ruili , Thomas Craig J , Xia Menghang , Deng Chuxia 
Published: June 2014

Abstract
Introduction
Breast cancer is a devastating disease that results in approximately 40,000 deaths each year in the USA. Current drug screening and chemopreventatitive methods are suboptimal, due in part to the poor specificity of compounds for cancer cells. Poly (ADP-ribose) polymerase 1 (PARP1) inhibitor (PARPi)-mediated therapy is a promising approach for familial breast cancers caused by mutations of breast cancer-associated gene-1 and -2 (BRCA1/2), yet drug resistance frequently occurs during the treatment. Moreover, PARPis exhibit very little effect on cancers that are proficient for DNA repair and clinical efficacy for PARPis as single-agent therapies has yet to be illustrated.

Methods
Using a quantitative high-throughput screening approach, we screened a library containing 2,816 drugs, most of which are approved for human or animal use by the Food and Drug Administration (FDA) or other countries, to identify compounds that sensitize breast cancer cells to PARPi. After initial screening, we performed further cellular and molecular analysis on lestaurtinib, which is an orally bioavailable multikinase inhibitor and has been used in clinical trials for myeloproliferative disorders and acute myelogenous leukemia.

Results
Our study indicated that lestaurtinib is highly potent against breast cancers as a mono-treatment agent. It also strongly enhanced the activity of the potent PARPi AG14361 on breast cancer cell growth both in vitro and in vivo conditions. The inhibition of cancer growth is measured by increased apoptosis and reduced cell proliferation. Consistent with this, the treatment results in activation of caspase 3/7, and accumulation of cells in the G2 phase of the cell cycle, irrespective of their BRCA1 status. Finally, we demonstrated that AG14361 inhibits NF-κB signaling, which is further enhanced by lestaurtinib treatment.

Conclusions
Lestaurtinib amplifies the ability of the PARP1 inhibitor AG14361 to kill BRCA1 mutant and wild-type breast cancer cells, at least in part, by inhibiting NF-κB signaling. Each of these drugs has been approved for clinical trials for several different cancers, thus, their combination treatment should be applicable for a breast cancer trial in the future.
Impact of appropriate antimicrobial treatment on transition from ventilator-associated tracheobronchitis to ventilator-associated pneumonia
Authors: Nseir Saad , Martin-Loeches Ignacio , Makris Demosthenes , Jaillette Emmanuelle , Karvouniaris Marios , Valles Jordi , Zakynthinos Epaminondas , Artigas Antonio 
Published: June 2014

Abstract
Introduction
Two small randomized controlled trials have suggested beneficial effects of antibiotic treatment in patients with ventilator-associated tracheobronchitis (VAT). The primary aim of this study is to determine the impact of appropriate antibiotic treatment on transition from VAT to ventilator-associated pneumonia (VAP) in critically ill patients. The secondary objective was to determine the incidence of VAP in patients with VAT.

Methods
This was a prospective observational multicenter study. All patients with a first episode of VAT were eligible. Patients with tracheostomy at intensive care unit (ICU) admission, and those with VAP prior to VAT were excluded. VAT was defined using all the following criteria: fever > 38°C with no other cause, purulent tracheal secretions, positive tracheal aspirate (≥105 cfu/mL), and absence of new infiltrate on chest X ray. Only VAP episodes diagnosed during the 96 h following VAT, and caused by the same bacteria, were taken into account. Antibiotic treatment was at the discretion of attending physicians. Risk factors for transition from VAT to VAP were determined using univariate and multivariate analysis. All variables from univariate analysis with P values <0.1 were incorporated in the multivariate logistic regression analysis.

Results
One thousand seven hundred and ten patients were screened for this study. Eighty-six, and 123 patients were excluded for tracheostomy at ICU admission, and VAP prior to VAT; respectively. One hundred and twenty two (7.1%) patients were included. 17 (13.9%) patients developed a subsequent VAP. The most common microorganisms in VAT patients were Pseudomonas aeruginosa (30%), Staphylococcus aureus (18%), and Acinetobacter baumannii (10%). Seventy-four (60%) patients received antimicrobial treatment, including 58 (47.5%) patients who received appropriate antimicrobial treatment. Appropriate antibiotic treatment was the only factor independently associated with reduced risk for transition from VAT to VAP (OR [95% CI] 0.12[0.02-0.59], P = 0.009). The number of patients with VAT needed to treat to prevent one episode of VAP, or one episode of VAP related to P. aeruginosa was 5, and 34; respectively.

Conclusions
Appropriate antibiotic treatment is independently associated with reduced risk for transition from VAT to VAP.
High dose of tigecycline for extremely resistant Gram-negative pneumonia: yes, we can
Authors: Garnacho-Montero José , Ferrándiz-Millón Carmen 
Published: June 2014

AbstractFew antimicrobials are currently active to treat infections caused by extremely resistant Gram-negative bacilli (ERGNB), which represent a serious global public health concern. Tigecycline, which covers the majority of these ERGNB (with the exception of Pseudomonas aeruginosa), is not currently approved for hospital-acquired pneumonia, and several meta-analyses have suggested an increased risk of death in patients receiving this antibiotic. Other studies suggest that the use of high-dose tigecycline may represent an alternative in daily practice. De Pascale and colleagues report that the clinical cure rate in patients with ventilator-associated pneumonia is significantly higher with a high dose of tigecycline than with the conventional dose, although mortality was unaffected. This high dose is safe; no patients required discontinuation or dose reduction.
Disruption of Protein-Tyrosine Phosphatase 1B Expression in the Pancreas Affects β-Cell Function
Authors: Liu Siming , Xi Yannan , Bettaieb Ahmed , Matsuo Kosuke , Matsuo Izumi , Kulkarni Rohit N. , Haj Fawaz G. 
Published: June 2014

AbstractProtein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of glucose homeostasis and energy balance. However, the role of PTP1B in pancreatic endocrine function remains largely unknown. To investigate the metabolic role of pancreatic PTP1B, we generated mice with pancreas PTP1B deletion (panc-PTP1B KO). Mice were fed regular chow or a high-fat diet, and metabolic parameters, insulin secretion and glucose tolerance were determined. On regular chow, panc-PTP1B KO and control mice exhibited comparable glucose tolerance whereas aged panc-PTP1B KO exhibited mild glucose intolerance. Furthermore, high-fat feeding promoted earlier impairment of glucose tolerance and attenuated glucose-stimulated insulin secretion in panc-PTP1B KO mice. The secretory defect in glucose-stimulated insulin secretion was recapitulated in primary islets ex vivo, suggesting that the effects were likely cell-autonomous. At the molecular level, PTP1B deficiency in vivo enhanced basal and glucose-stimulated tyrosyl phosphorylation of EphA5 in islets. Consistently, PTP1B overexpression in the glucose-responsive MIN6 β-cell line attenuated EphA5 tyrosyl phosphorylation, and substrate trapping identified EphA5 as a PTP1B substrate. In summary, these studies identify a novel role for PTP1B in pancreatic endocrine function.
Radiofrequency Ablation, an Effective Modality of Treatment in Tumor-Induced Osteomalacia: A Case Series of Three Patients
Authors: Jadhav Swati , Kasaliwal Rajeev , Shetty Nitin S. , Kulkarni Suyash , Rathod Krantikumar , Popat Bhavesh , Kakade Harshal , Bukan Amol , Khare Shruti , Budyal Sweta , Jagtap Varsha S. , Lila Anurag R. , Bandgar Tushar , Shah Nalini S. 
Published: June 2014

Context:
Tumor-induced osteomalacia is curable if the tumors can be totally excised. However, when the tumors are present in locations that make surgery disproportionately risky, the need for less invasive strategies like radiofrequency ablation (RFA) is realized.

Patients and Methods:
We describe three patients with suspected tumor-induced osteomalacia who were treated in our department between 2006 and 2013 with tumors in surgically difficult locations and were subjected to single or multiple sessions of RFA. The response was documented in terms of symptomatic improvement, phosphorus normalization, and follow-up 99mTechnitium-labelled hydrazinonicotinyl-Tyr3-octreotide (99mTc HYNIC TOC) scan.

Results:
Two of the three individuals, patient A (with a 1.5 × 1.2-cm lesion in the head of the right femur) and patient B (with a 1.3 × 1.2-cm lesion on the endosteal surface of the shaft of the left femur), achieved complete remission with single sessions of RFA. Three months after the procedure, 99mTc HYNIC TOC scans revealed the absence of uptake at the previous sites, corroborating with the clinical improvement and phosphorus normalization. Patient C had a large 5.6 × 6.5-cm complex lesion in the lower end of the left femur with irregular margins, loculations, and bone grafts placed in previous surgery. He failed to achieve remission after multiple sessions of RFA due to the complex nature of the lesion, although the tumor burden was reduced significantly as documented on serial 99mTc HYNIC TOC scans.

Conclusions:
Although surgery remains the treatment of choice, RFA could be an effective, less invasive, and safe modality of treatment in judiciously selected patients.
Synthesis of Pyrrolidinium Salts Using a Triazine-based Reagent under Mild Conditions
Authors: Kitamura Masanori , Yamamura Seina , Kobayashi Hiroko , Yamamoto Mariko , Tada Kayo , Hioki Kazuhito , Yamada Kohei , Kunishima Munetaka 
Published: June 2014

Abstract
Various pyrrolidinium salts were synthesized from N,N-dialkyl-N′,N′-dimethylbutane-1,4-diamine using 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) under mild conditions. Cyclization reaction for the pyrrolidinium salts proceeded in high yields in polar solvents such as methanol and acetonitrile.
Game Change in Colorado: Widespread Use Of Long‐Acting Reversible Contraceptives and Rapid Decline in Births Among Young, Low‐Income Women
Authors: Ricketts Sue , Klingler Greta , Schwalberg Renee 
Published: June 2014

ContextLong‐acting reversible contraceptive (LARC) methods are recommended for young women, but access is limited by cost and lack of knowledge among providers and consumers. The Colorado Family Planning Initiative (CFPI) sought to address these barriers by training providers, financing LARC method provision at Title X–funded clinics and increasing patient caseload.MethodsBeginning in 2009, 28 Title X–funded agencies in Colorado received private funding to support CFPI. Caseloads and clients’ LARC use were assessed over the following two years. Fertility rates among low‐income women aged 15–24 were compared with expected trends. Abortion rates and births among high‐risk women were tracked, and the numbers of infants receiving services through the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) were examined.ResultsBy 2011, caseloads had increased by 23%, and LARC use among 15–24‐year‐olds had grown from 5% to 19%. Cumulatively, one in 15 young, low‐income women had received a LARC method, up from one in 170 in 2008. Compared with expected fertility rates in 2011, observed rates were 29% lower among low‐income 15–19‐year‐olds and 14% lower among similar 20–24‐year‐olds. In CFPI counties, the proportion of births that were high‐risk declined by 24% between 2009 and 2011; abortion rates fell 34% and 18%, respectively, among women aged 15–19 and 20–24. Statewide, infant enrollment in WIC declined 23% between 2010 and 2013.ConclusionsPrograms that increase LARC use among young, low‐income women may contribute to declines in fertility rates, abortion rates and births among high‐risk women.
Performing an intervention in the space between art and education
Authors: May Heidi , O’Donoghue Dónal , Irwin Rita 
Published: June 2014

Abstract
In this article, we consider and discuss an artist-teacher residency staged at our university that explored and examined relations between art, learning and teaching. Comprising artists, pedagogues, becoming teachers and researchers, this residency was initiated to examine how becoming art teachers (teacher candidates) come to understand pedagogy in their field, and to create an event where they would encounter qualities of pedagogy through art-making. The article begins with a short discussion of the pedagogical turn in contemporary art and interventionist art practices before describing the artist-teacher residency that bears similarities to certain socially engaged art practices. Drawing upon the concept of emergent knowledge, we reflect upon the teacher candidates’ accounts of the experience of participating in the artist-teacher residency. We consider the impact that these experiences had on teacher candidates’ understandings of art and pedagogy. Throughout the project, a/r/tography offered a rich form of living enquiry that initiated processes of learning to learn.
Cultural mismatch and creativity in arts education
Authors: Leong Samuel 
Published: June 2014

Abstract
Culture has been found to impact upon creativity, which is valued as ‘a motor of economic and social innovation’ in a world that is experiencing rapid cultural changes and increasing cultural diversity. Recent research has given attention to the problem of cultural mismatch in education, with studies showing that children’s success at school depends on the extent to which the knowledge, background and values of their families match the school’s values and priorities. The greater the mismatch between the two cultures, the less likely the children would benefit from schooling. When schools fail to effectively address the mismatch, social inequalities and academic failure are perpetuated. But the problem is not confined to home versus school cultures, and can be present in other kinds of mismatches such as western-eastern cultures and traditional-popular cultures. This article discusses this problem in the context of creative education and the advent of prosumerism.
文化對創造力的影響已為人發現，在文化迅速轉變和文化多元性遞增的世 界，創造力被視為「經濟和社會革新的原動力」。最近研究已關注到教育 方面文化錯配的問題， 並且有研究顯示，孩子在學校的成功，取決於家庭的 知識、背景和價值，跟學校的價值和優先次序觀念的吻合程度。兩者文化之 間的差異越大，孩子於教育的得益可能越少。當學校不能有效地正視這種錯 配，社會不平等和學術失敗便永遠存在。但問題不僅出現於家庭文化與學校 文化之間，也可以是存在於其他方面的錯配，例如東方與西方文化、傳統與 流行文化。本文就創意教育的環境及產消主義的出現，探論這個問題。
Making things happen through networks: Connecting arts educators to enhance collective knowledge in the field
Authors: de Eça Teresa Torres 
Published: June 2014

Abstract
New open source movements are proposing cohesion and syncretism in social networks. Such movements present an alternative way of thinking and behaving through synergy and collaboration. In Arts education theory and practice we probably face the benefits of the many social networks in the field for linking people. Organizations and individuals are working together at a global level and at medium and small scales in a myriad of groups spread out in very different linguistic territories. As art teachers and educational researchers we may seek transformation tools, and the collective intelligence arising from these groups may bring us a rich array of possibilities to inform our pedagogical and artistic interconnected fields. From a networking point of view, visibility, dialogue and action are emerging possibilities for pedagogic/artistic real actions. The future strengths or weakness of arts education will depend on the actions behind these groups, on the way they circulated among the Internet and produce physical impact in different geographical and cultural sites.
Os movimentos de código aberto introduziram conceitos de coesão e sincretismo nas redes sociais. Estes movimentos apresentam maneiras de pensar e de fazer alternativas através de sinergia e colaboração. Na Educação artística, tanto na teoria como na prática, estamos a beneficiar das variadíssimas redes sociais para comunicar e para conectar pessoas. Organizações e indivíduos a um nível global ou local estão a trabalhar juntos em inúmeros grupos espalhados através de variados territórios linguísticos. Nesse contexto, a inteligência coletiva que emerge desses grupos poderá trazer-nos um vasto leque de potencialidades para informar os nossos campos nos domínios pedagógico e artístico. Do ponto de vista relacional, o diálogo e a ação são possibilidades latentes para ações pedagógicas/artísticas efetivas. A força ou a fragilidade da Educação artística dependerá das ações levadas a cabo por esses grupos, pela maneira como eles circulam na Internet e, de como produzem impacto físico em diferentes lugares geográficos e culturais.
Collaborative visual mapping as performance: Visual Arts pre-service teachers’ reflections on practicum
Authors: Cutcher Alexandra , Rousell David 
Published: June 2014

Abstract
This poetic, visual essay describes a collaborative, visual performance enacted by a cohort of Visual Arts pre-service teachers. The students mapped memories and experiences of their first teaching experience from practicum, motivated by discussion, stimuli and feedback. The mapping process had several loops where the students worked collectively to map their visual reflections onto large-scale canvases. These performance paintings became palimpsests, portraying layers of collaborative practice and learning. The networks of interactions, dialogue, relationships and group dynamics were exposed in the material practice of the participants. As an a/r/tographical rendering, the process simultaneously documented the group’s subjective expressions as well as their emergent teacher identities. The collaborative model was at once both powerful and provocative as the dynamics of collective art-making evolved into reflections of developing pedagogy. This representation is a multivocal portrayal of the research; the voices of the researchers, students and artworks compete with and complement the other.
The La Grande France circle (1900–1903): Littérature coloniale, transcolonial synergies and the Belle Époque avant-gardes
Authors: Kapor Vladimir 
Published: June 2014

Abstract
This article explores the pioneering role that the literary and intellectual circle formed by Marius-Ary Leblond around the journal La Grande France (1900–1903) played in the gestation of both la littérature coloniale of the Third French Republic and postcolonial Francophone literature. Following a bio-bibliographical account of the circle and its members, it will present the journal’s aesthetic and ideological programme with a particular emphasis on theoretical reflection about colonial literature, with a view to reassessing the circle’s legacy. In addition, through a study of the main agents (Pierre Bourdieu) behind La Grande France, and their affiliations, both colonial and extra-colonial, it aims to document and reflect on the unlikely connection between colonial ideology and avant-garde aesthetics and business model, and on the consequences of this cohabitation.
Cet article se propose d’explorer le rôle liminaire que le cercle littéraire et intellectuel fondé par Marius-Ary Leblond autour de la revue La Grande France (1900–1903) a joué dans la gestation de la littérature coloniale de la Troisième République et de la littérature francophone postcoloniale. Après une présentation bio-bibliographique du cercle et de ses membres, il s’attachera à décrire la plateforme esthétique et idéologique de la revue, en s’intéressant en particulier à la réflexion théorique sur la littérature coloniale qui s’y ébauche, afin de revisiter le rayonnement intellectuel du cercle et sa postérité. En outre, à travers une étude des agents (Bourdieu) principaux de la revue, et de leurs affiliations coloniales aussi bien qu’extra-coloniales, il se donnera pour tâche de documenter des liens inattendus qui se tissent entre l’idéologie coloniale, et l’esthétique et le modèle économique avant-gardistes, et d’engager une réflexion sur les causes et les conséquences de cette cohabitation.
Postcolonial Enlightenment: Reformers of Islam in Sarkozy’s France
Authors: Qadiri Sura 
Published: June 2014

Abstract
This article presents the emergence of a problematic language of mimicry and political conformism amongst a group of French-based reformers of Islam. It focuses in particular on the increased use of the term ‘enlightenment’ when putting forward their ideas for reforming Muslim communities and sacred scriptures. This trend emerges against a backdrop of mounting political pressure against Muslims in France exacerbated by public explorations of Frenchness that intensify in their racial and historical exclusiveness, particularly with the rise of Nicholas Sarkozy starting around 2005. Reformers of Islam seem keen to apply the term to any suggestions they make, showing little engagement with the historical Enlightenment, and little questioning of the contemporary interpretations of it by the French political establishment. In the work of these reformers, enlightenment merely becomes an ill-defined process through which Muslim communities may gain access to French identity.
Cet article présente l’émergence d’un discours caractérisé par l’imitation sémantique et le conformisme politique parmi certains réformateurs de l’islam de langue française. Il s’intéresse en particulier à l’usage de plus en plus fréquent du terme “lumières” dans la présentation de leurs idées visant à réformer la communauté musulmane et les textes sacrés. Cette tendance se fait jour dans un contexte marqué par une pression politique croissante à l’égard des musulmans en France et le discours public autour de l’identité nationale, définie par des paramètres ethniques et historiques de plus en plus étriqués, qui accompagne la montée au pouvoir de Nicolas Sarkozy à partir de 2005. Les réformateurs de l’islam semblent s’appliquer à apposer ce terme à chacune de leur suggestions, sans réellement se pencher sur les Lumières du XVIIIè siècle ou s’interroger sur les interprétations qu’en fait aujourd’hui la classe politique. Chez ces auteurs, les Lumières deviennent un processus mal défini qui permettrait aux Musulmans d’accéder à l’identité française.