bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between interleukin-10, -12, and − 18 and periodontal health and disease: a cross-sectional study
Authors: Cebesoy Elif Ilke , Altaca Müge , Kocak-Oztug Necla Asli , Bingül Ilknur , Cifcibasi Emine 
Published: July 2024

Abstract
Objective
We assessed the levels of Interleukin-10 (IL-10), Interleukin-12 (IL-12), and Interleukin-18 (IL-18) in the gingival crevicular fluid (GCF) of subjects with advanced periodontitis (SIII-SIV) compared to healthy controls and evaluated their correlations with clinical measurements.

Methods
This cross-sectional study involved subjects (n = 60) diagnosed with stage III grade B-C (n = 13) to stage IV grade C (n = 17) periodontitis, and periodontally healthy controls (n = 30). Clinical periodontal measurements involved full-mouth. The concentrations of IL-10, IL-12, and IL-18 were determined using enzyme-linked immunosorbent assay (ELISA).

Results
There were no significant differences in IL-12 level and IL-18/IL-10 ratio between the healthy and periodontitis groups (p = 0.413, p = 0.636, respectively). The IL-10 and IL-18 levels were significantly higher in the periodontitis group than in controls (p < 0.001, p < 0.001, respectively). Significant associations were observed between the periodontitis and IL-10 and IL-18 levels (OR = 1.46, %95 CI 1.19–1.795; OR = 1.13, %95 CI 1.059–1.207, respectively) (p < 0.001, p < 0.001, respectively).

Conclusions
There was a correlation between pocket depth and the presence of IL-18 and a strong association between periodontitis and a high level of IL-18. However, there were no direct correlations among the three biomarkers and IL-18/IL-10 ratio, indicating that their roles in periodontal health are complex and multidimensional.

Clinical relevance
Understanding the cytokine dynamics in GCF provides valuable insights into their potential clinical implications for periodontal disease diagnosis, risk assessment, and tailored therapeutic interventions.
Trajectories of mental health problems in unaccompanied young refugees in Germany and the impact of post-migration factors – a longitudinal study
Authors: Hornfeck Fabienne , Garbade Maike , Kappler Selina , Rosner Rita , Pfeiffer Elisa , Sachser Cedric , Kindler Heinz 
Published: July 2024

AbstractUnaccompanied young refugees (UYRs) are at an elevated risk of continuing psychological distress, including posttraumatic stress symptoms (PTSS), depression, and anxiety. The post-arrival situation in a host country plays an important role in increasing or reducing mental health risks for UYRs. This study aimed to examine the trajectory of psychological distress and post-migration factors experienced by UYRs in Germany with five assessments every six months over a two-year period.Standardised self-report questionnaires were used to assess PTSS (CATS-2), depression (PHQ-9), and anxiety (GAD-7) symptoms. Material and social stressors (DSSYR), sociocultural adjustment (BSAS), frequency of contact with family members, and distress regarding asylum status were included as post-migration factors. N = 131 UYRs (Mage = 17.04; SDage = 1.46; 81.1% male) living in residential care facilities in Germany were included in this study. There was a significant loss to follow up with n = 77 after 12 months at T2 (59% attrition), and n = 37 after 24 months at T4 (28% attrition).At baseline, clinically relevant symptom scores were found in 48.1% for PTSS, 42.0% for depression, and 22.9% for anxiety. Analysis of latent growth curve models revealed that the symptom severity of depression and anxiety did not change substantially over one year, but PTSS showed a significant decline. The number of traumatic events affected initial levels of mental health problems but not their trajectory over time. The impact of post-migration factors varied between measurement points and outcome measures and did not result in a homogeneous pattern.Despite limitations, this study demonstrated the persistence of high levels of psychological distress in UYRs. Effective interventions are required at an early stage to prevent chronic trajectories and support systems should adapt to constantly changing circumstances.Trial registration number/date of registration: DRKS00017453/11th December 2019.
Disentangling the effects of self-control and the use of tobacco and cannabis on violence perpetration from childhood to early adulthood
Authors: Loher Michelle , Steinhoff Annekatrin , Bechtiger Laura , Ribeaud Denis , Eisner Manuel , Shanahan Lilly , Quednow Boris B. 
Published: July 2024

AbstractAssociations among self-control, substance use (e.g., tobacco and cannabis use), and violence perpetration have been documented during the adolescent years, but the direction of these associations is not well understood. Using five assessments (covering 9 years) from a prospective-longitudinal study, we examined self-control as a precursor and subsequent mechanism of associations between adolescent substance use and physical violence perpetration. Data came from a large, ethnically diverse sample (n = 1,056). Youth reported their self-control at ages 11, 13, 15, 17, and 20; and their tobacco and cannabis use, and physical violence perpetration at ages 13, 15, 17, and 20. Cross-lagged panel analyses examined associations between these constructs over time. More self-control in late childhood and early adolescence was associated with less future tobacco and cannabis use and physical violence perpetration. Tobacco use was partially associated with more physical violence over time; these associations were not mediated by self-control. Tobacco use in early adolescence was associated with future cannabis use; during late adolescence, tobacco and cannabis use were reciprocally associated over time. Cannabis use was not associated with future physical violence perpetration. Early adolescent self-control plays an important role in later substance use and violence perpetration, and tobacco use has unique links with both later cannabis use and violence perpetration. Supporting the capacities for self-control in late childhood and early adolescence and preventing the initiation and use of entry-level substances could play an important role in preventing both substance use and violence perpetration and their many costs to society.
Direct measurement of magnetocaloric effect (MCE) in frustrated Gd-based molecular complexes
Authors: Zhang Yu , Nomoto Tetsuya , Yamashita Satoshi , Akutsu Hiroki , Yoshinari Nobuto , Konno Takumi , Nakazawa Yasuhiro 
Published: July 2024

AbstractGeneration of low temperatures below 1 K has been required for applications and fundamental research, given this, development of new materials utilized for demagnetization cooling has extensively been performed in recent years. Here, we studied two polynuclear Gd3+-based molecular compounds of Gd0.33[Gd4(OH)4(OAc)3][Rh4Zn4(L-cys)12]·32H2O (1Gd) and Gd0.33[Gd4(OH)4(OAc)3][Ir4Zn4(L-cys)12]·28H2O (2Gd) (L-cys = L-cysteinate) which show paramagnetic even at low temperatures due to their frustrated arrangement of Gd3+ ions. We discuss the magnitude of the magnetocaloric effect (MCE) in them inferred from the isothermal magnetic entropy change ($${\Delta S}_{\text{M}}$$

Δ
S

M

) from isothermal magnetization data. The − $$\Delta S_{{\text{M}}}^{{{\text{max}}}}$$

Δ

S

M

max

of 1Gd and 2Gd are 15.15 J kg−1 K−1 and 17.49 J kg−1 K−1 occur at 2.0 K under an applied field from 0 to 7 T, respectively. We also discussed the results of heat capacity measurement under magnetic fields to confirm the validity of the entropy change for 1Gd. Furthermore, with an aim of detecting their MCE directly, we have developed a new non-magnetic and metal-free magnetocaloric measurement cell. The adiabatic temperature change ($$\Delta T_{{{\text{ad}}}}$$

Δ

T
ad

) occurs in a small amount of sample on an order of 102-microgram with the application and removal of various magnitude magnetic fields starting from several initial temperatures were detected directly, to evaluate the potential of them to be a refrigerant for an adiabatic demagnetization refrigerator. The instrumental design for direct measurements of MCE is described along with the construction details.
Reference-dependent discounting
Authors: Attema Arthur E. , Li Zhihua 
Published: July 2024

AbstractReference-dependence has become a widely established phenomenon in decision making under risk, not only for monetary outcomes but also for other outcomes, e.g., related to health. However, when the prospects involve risk about timing (the time of receipt of outcomes), rather than the outcomes themselves, much less is known about reference-dependence. This study extends discounted utility to incorporate reference-dependence and is the first to test it in timing prospects. We are also the first to estimate the probability weighting function for timing prospects. For both timing and outcome risk tasks, we replicate the typical fourfold pattern of risk attitudes: risk seeking for low-probability gains, risk aversion for high-probability gains, risk aversion for low-probability losses and risk seeking for high-probability losses. In other words, we find substantial pessimism with regard to high probabilities in the gain domain and low probabilities in the loss domain, and probabilistic optimism for low probabilities in the gain domain and high probabilities in the loss domain. Furthermore, we report loss aversion for outcome risks, while for timing risks, we find the opposite result, which we term earliness seeking. In sum, we find substantial empirical support for reference-dependent discounting. Our results show that psychological biases are also important when timing is risky, although the direction of bias may differ.
Discovering the effect of combination of celecoxib and sorafenib on hepatocellular carcinoma
Authors: Gu Wang , Zeng Dongyun , Zhang Chao 
Published: July 2024

Abstract
Introduction
Hepatocellular carcinoma (HCC) is a common and fatal cancer, and its molecular mechanisms are still not fully understood. This study aimed to explore the potential molecular mechanisms and immune infiltration characteristics of celecoxib combined with sorafenib in the treatment of HCC by analyzing the differentially expressed genes (DEGs) from the GSE45340 dataset in the GEO database and identifying key genes.

Methods
The GSE45340 dataset was downloaded from the GEO database, and DEGs were screened using GEO2R, and visualization and statistical analysis were performed. Metascape was used to perform functional annotation and protein–protein interaction network analysis of DEGs. The immune infiltration was analyzed using the TIMER database, and the expression of key genes and their relationship with patient survival were analyzed and verified using the UALCAN database.

Results
A total of 2181 DEGs were screened through GEO2R analysis, and heat maps were drawn for the 50 genes with the highest expression. Metascape was used for enrichment analysis, and the enrichment results of KEGG and GO and the PPI network were obtained, and 44 core genes were screened. Analysis of the TIMER database found that 12 genes were closely related to tumor immune infiltration. UALCAN analysis further verified the differential expression of these genes in HCC and was closely related to the overall survival of patients.

Conclusions
Through comprehensive bioinformatics analysis, this study identified a group of key genes related to the treatment of HCC with celecoxib combined with sorafenib. These genes play an important role in tumor immune infiltration and patient survival, providing important clues for further studying the molecular mechanism of HCC and developing potential therapeutic targets.
In-vacuum undulators for the first phase beamlines of Korea-4GSR
Authors: Ha Changwan , Kwon Ik Seon , Kim Ki-Jeong , Kim Jehan , Lim Jae-Hong 
Published: July 2024

AbstractKorea-4GSR, a new synchrotron radiation facility currently under construction in Ochang, Chungbuk, South Korea, introduces three types of in-vacuum undulators (IVUs) for its first phase hard X-ray beamlines: IVU20, IVU22, and IVU24. These IVU types share a common 3-m-long framework capable of adjusting the magnetic gap size between 5 and 18 mm, but they differ in the undulator period length (λu). This study characterizes their photon beams in terms of brightness, spectral coverage, source size, angular divergence, coherent fraction, coherent flux, and total and central cone radiation powers, using undulator calculations. The three IVU types are comparable in brightness. IVU20 is the most coherent, although lacking spectral continuity at around 7.5 keV. IVU22 and IVU24 ensure spectral continuity, but their coherent flux is moderately compromised. The performance of the undulators is assessed in comparison to the Pohang Light Source-II (PLS-II) undulator and the U21 undulator at Advanced Photon Source Upgrade (APS-U).
Load of the ash dieback pathogen hymenoscyphus fraxineus differs in soil
Authors: Böhm Jan Werner , Zübert Christina , Kahlenberg Georgia , Jochner-Oette Susanne , Kube Michael 
Published: July 2024

AbstractThe ascomycete Hymenoscyphus fraxineus causes the devastating ash dieback disease of European ash (Fraxinus excelsior L.). Spore traps are often used to measure the amount of ascospores in the environment, but the pathogen-load of the soil in ash stands has not been recorded so far. This is of particular interest with regard to the occurrence of ash stem necrosis, a decisive factor for the severe course of the disease. In order to gain a more differentiated insight into the pathogen-load in ash stands, we analysed soil samples from four ash tree sites in southern Germany, covering a clone plantation, two seed orchards and a forest. The pathogen-load was determined using a quantitative TaqMan real-time PCR assay for ten to twenty plots per stand. Results obtained by the species-specific assay highlighted that the pathogen-load is heterogeneously distributed in the ash stands. H. fraxineus DNA targets were detected in 17% of the soil samples. The pathogen-load differed according to soil depth, with the highest pathogen abundance in the top 5 cm, followed by 5–10 cm and finally 10–15 cm. Pathogen-load and thereby infection pressure were found to be highly variable for the individual trees in one stand. Overall, the study discovered detectable levels of H. fraxineus in the soil of all four study sites, which supports the hypothesis that H. fraxineus can be found in the soil of ash stands. The qPCR approach was found to be an effective method for monitoring the load of H. fraxineus in soil and for demonstrating the successful application of the method on the sample type of custom-made spore traps. Results suggest the implication of site-specific pathogen-load determination in future H. fraxineus-monitoring and selection of less susceptible ash trees for breeding and seed production.
The role of patient-related factors in the implementation of a multimodal home-based rehabilitation intervention after discharge from inpatient geriatric rehabilitation (GeRas): a qualitative process evaluation
Authors: Maier Leonie , Benzinger Petra , Abel Bastian , Roigk Patrick , Bongartz Martin , Wirth Isabel , Cuvelier Ingeborg , Schölch Sabine , Büchele Gisela , Deuster Oliver , Bauer Jürgen , Rapp Kilian , Ullrich Charlotte , Wensing Michel , Roth Catharina 
Published: July 2024

Abstract
Background
Structured aftercare programs are implemented to facilitate the transition from rehabilitation centers to patients’ home environments. Taking the program GeRas as an example, this paper aims to evaluate the influence of patient-related factors on the implementation of the geriatric aftercare program GeRas from patients' and providers' perspectives.

Methods
To capture patients’ and providers’ perspectives, qualitative interviews were conducted using a semi-structured interview guide. The analysis was inductive–deductive and based on the thematic analysis by Braun and Clarke and guided by Domain IV of the CFIR.

Results
16 participants (10 patients, 4 providers, 2 family members) were interviewed from May 2023 to November 2023. Patient-related factors were perceived as an important aspect during the implementation of the GeRas program. The results were allocated to the four Constructs of Domain IV of the CFIR (Motivation, Opportunity, Capability, Needs). Especially patients’ intrinsic motivation, social environment, and physical capabilities seemed to be crucial for successful implementation. While extrinsic motivation can mitigate missing personal capabilities, it cannot replace the presence of intrinsic motivation and capabilities. The results showed that patient-related factors are interlinked.

Discussion/conclusion
The relevance of patient-related factors during the implementation of the GeRas program shows that such programs must consider these factors during intervention planning.
Novel Plasmopara viticola isolate surpasses grapevine Rpv3.1 and Rpv3.2 resistance but not Rpv12
Authors: Gouveia Catarina , Santos Rita B. , Zukic Selma , Manthey Thorsten , Malhó Rui , Figueiredo Andreia , Buchholz Guenther 
Published: July 2024

AbstractGrape downy mildew, caused by the oomycete Plasmopara viticola, is a major threat to Vitis vinifera grape production. Several breeding programs rely on resistance factors (Rpvs) from American and Asian Vitis species to confer resistance to P. viticola. Although the use of these crossing hybrids offers a promising strategy for disease control, variants capable of overcoming host resistance are emerging. A thorough characterization of these isolates is needed to define new strategies for breeding programs. The investigation of varying aggressiveness of two P. viticola pathotypes was investigated. One pathotype is unable to overcome Rpv3.1 based resistance and another pathotype was isolated from a grapevine carrying the Rpv3.1 locus. Their aggressiveness was evaluated on five grapevine genotypes harboring distinct combinations of Rpv loci. Macroscopic and microscopic development of the pathogen was characterised throughout its colonization of grapevine leaves. Our findings demonstrate that the P. viticola isolate NW-10/16 is not only capable of overcoming Rpv3-based resistance but also exhibited a faster growth, increased sporulation, and a denser mycelial colonization within the plant mesophyll when compared with the avRpv3 + isolate in susceptible plants. The identification and characterization of new, more aggressive, P. viticola pathotypes is crucial to promote durable management of the resistant grapevine hybrids and to mitigate the threat of downy mildew.
Insights into role of microstructure in TNT adsorption performances onto zeolite, diatomite and kaolinite particles
Authors: Wu Yaoguo , Meng Chengzhen , Guo Qian , Sun Ran , Hu Sihai , Yi Mengying , Shen Jiaru , Sun Changyu 
Published: July 2024

AbstractAdsorption performances of one pollutant on different adsorbents likely depend on the adsorbent microstructures heavily. Hereon, zeolite, diatomite and kaolinite particles were selected as inexpensive adsorbents in this study with 2,4,6-trinitrotoluene (TNT) as an organic pollutant for the batch test to verify the effect of adsorbent microstructure on TNT adsorption performance. The results of kinetic, adsorption isothermic, and thermodynamic analyses indicated that the adsorption process of TNT on three particles is controlled by chemisorption, and that both are non-spontaneous entropic endothermic reactions, although they have their own specific adsorption capacities, equilibration times, and kinetic rates. Comprehensively analyzing the characterization data and adsorption performances of the particles shows that, the pore physical properties including the pore diameter distribution and volume obviously control the adsorption capacities, and well the pore surface chemical properties such as the functional groups affect the adsorption kinetics; the microstructure affects the performances through the synergistic effect of physical and chemical pathways and results in the special performances. Briefly, a particle has its special microstructure and then determinedly unique performance. The finding provides insights into the role of the microstructure of the particles in their performances, and significances for selecting and utilizing the adsorbents in water treatment.
Impact of database choice and confidence score on the performance of taxonomic classification using Kraken2
Authors: Liu Yunlong , Ghaffari Morteza H. , Ma Tao , Tu Yan 
Published: July 2024

AbstractAccurate taxonomic classification is essential to understanding microbial diversity and function through metagenomic sequencing. However, this task is complicated by the vast variety of microbial genomes and the computational limitations of bioinformatics tools. The aim of this study was to evaluate the impact of reference database selection and confidence score (CS) settings on the performance of Kraken2, a widely used k-mer-based metagenomic classifier. In this study, we generated simulated metagenomic datasets to systematically evaluate how the choice of reference databases, from the compact Minikraken v1 to the expansive nt- and GTDB r202, and different CS (from 0 to 1.0) affect the key performance metrics of Kraken2. These metrics include classification rate, precision, recall, F1 score, and accuracy of true versus calculated bacterial abundance estimation. Our results show that higher CS, which increases the rigor of taxonomic classification by requiring greater k-mer agreement, generally decreases the classification rate. This effect is particularly pronounced for smaller databases such as Minikraken and Standard-16, where no reads could be classified when the CS was above 0.4. In contrast, for larger databases such as Standard, nt and GTDB r202, precision and F1 scores improved significantly with increasing CS, highlighting their robustness to stringent conditions. Recovery rates were mostly stable, indicating consistent detection of species under different CS settings. Crucially, the results show that a comprehensive reference database combined with a moderate CS (0.2 or 0.4) significantly improves classification accuracy and sensitivity. This finding underscores the need for careful selection of database and CS parameters tailored to specific scientific questions and available computational resources to optimize the results of metagenomic analyses.
A Dynamic Scheduling Method for Logistics Supply Chain Based on Adaptive Ant Colony Algorithm
Authors: Zhang Yinxia , Wang Liang 
Published: July 2024

AbstractTo reduce the dynamic scheduling cost of logistics supply chain and improve customer satisfaction, this paper proposes a dynamic scheduling method for logistics supply chain based on adaptive ant colony algorithm. First, determine the goal of dynamic scheduling in the logistics supply chain. Second, considering supplier satisfaction, transportation costs, and maximum delivery distance constraints, a dynamic scheduling model for logistics supply chain is constructed. Then by smoothing the pheromones and designing a transition function, adjusting factors are introduced to update the pheromone rules. Finally, based on the adaptive ant colony algorithm, the solution of the dynamic scheduling function of the logistics supply chain is solved to achieve the dynamic scheduling of the current logistics supply chain. The experimental results show that after 19 iterations, the method can search for the optimal route A1 group with a length of 33.85 km, with fewer iterations and shorter paths. The total cost is 114,290 yuan, and the degree of cargo loss is low, with a maximum of only 0.14%. The task completion time is short, customer satisfaction is above 0.85, and the scheduling accuracy is 99.9%. It can effectively control costs, improve customer satisfaction, and accurately arrange logistics supply chains.