bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinico‐Mycological Profile of Tinea Capitis in North India and Response to Griseofulvin
Authors: Singal Archana , Rawat Sudha , Bhattacharya Sambit Nath , Mohanty Sandip , Baruah Manik Chand 
Published: July 2014

AbstractThere is a paucity of literature on tinea capitis from North India. The response to griseofulvin has not been studied as well. We studied 153 consecutive patients of tinea capitis for clinical patterns, causative dermatophytic species, clinico‐etiological correlation, and response to griseofulvin. Culture and sensitivity were done on all patients. All patients were treated with griseofulvin for 6‐8 weeks; non‐responders were further treated with fluconazole. Ninety percent of the patients were less than 15 years of age, 75% belonged to poor socioeconomic groups and 19% had a family history of tinea capitis. The seborrheic variant was the commonest clinical pattern seen in 47.8% of patients, followed by grey patch, black dot, kerion, and alopecia‐areata‐like tinea capitis in 35.9%, 8.5%, 6.5% and 1.3% of patients, respectively. Only 66% of patients had a positive culture. T. violaceum was the commonest dermatophytic species isolated in 38% patients. M. audouinii, T. schoenleinii, T. tonsurans, M. gypseum, T. verrucosum and T. mentagrophytes were isolated in 34%, 10%, 9%, 3%, 3% and 3% of patients, respectively. Of the isolates 94% were susceptible to griseofulvin, and 100% were susceptible to fluconazole. By using griseofulvin for 6–8 weeks 97.4% of the patients were cured; nonresponders required therapy with fluconazole for cure. To conclude, tinea capitis is still a disease of younger people of poor socioeconomic status. T. violaceum and M. audouinii are the most common responsible dermatophytes. The response to griseofulvin was excellent, and it should be used as a first line therapy.
Disseminated Superficial Actinic Porokeratosis with Both Typical and Prurigo Nodularis‐like Lesions
Authors: Kang Byung Duk , Kye Young Chul , Kim Soo Nam 
Published: July 2014

AbstractWe report a 50‐year‐old Korean patient who developed a disseminated superficial actinic porokeratosis (DSAP) with two types of lesions. One was a typical DSAP lesion clinically and histopathologically. The other was clinically similar to prurigo nodularis, but histologic examination showed the findings of porokeratosis such as cornoid lamellae and loss of the granular layer in addition to those of chronic lichenified dermatitis, so it could be described as prurigo nodularis‐like porokeratosis. The nodular lesions seemed to develop on preexisting typical lesions of DSAP mainly during the summer by the aggravation of pruritic symptoms and scratching associated with sun exposure. Although we could not find any published reports describing lesions like those of our case, we think that such prurigo nodularis‐like porokeratosis can develop in patients with DSAP in some situations involving pruritus and scratching.
Sarcoidosis Associated with Psoriasis Vulgaris
Authors: Usuki Kazunari , Hamada Hiroshi , Terasaki Yutaro , Hiwatashi Shuko , Hisadome Hirofumi , Setoyama Mitsuru , Kanzaki Tamotsu , Mera Syuji 
Published: July 2014

AbstractWe report a 70‐year‐old patient with sarcoidosis associated with psoriasis vulgaris. He had a nodule on the medial lower lid of his right eye. Oral corticosteroid for the sarcoid lesions and oral PUVA for psoriasis were employed. The cutaneous lesion disappeared within two months after starting the therapy. No relapse of sarcoidosis has been seen for eight years. The association of sarcoidosis with psoriasis has been previously reported; however, it is still unclear whether this association coincidental or meaningful.
The Role of the Antioxidative Defense System in Papulopustular Acne
Authors: Basak Pinar Y. , Gultekin Fatih , Kilinc Ibrahim 
Published: July 2014

AbstractAcne vulgaris frequently occurs in the second decade of life. The pathogenesis of the disease is multifactorial. In this study, we aimed to investigate the role of reactive oxygen species in inflammation of acne by determining the activity of antioxidant defense enzymes in leukocytes. Fifty‐two patients with papulopustular type acne vulgaris and 36 healthy controls were enrolled. The severity of the disease was examined by the Global Acne Grading System, and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px) and catalase (CAT) enzymes as well as the level of thiobarbituric acid reactive substance (TBARS) were detected in leukocytes. The activities of SOD and GSH‐Px were significantly decreased in the acne group. CAT activity and TBARS level were higher in patients than controls. Only a poor correlation was detected between GSH‐Px activity and severity of the disease. Antioxidative defense enzymes are impaired in papulopustular acne, and drugs with antioxidative effects might be valuable in treatment.
Long‐term Follow‐up Study of Onychomycosis: Cure Rate and Dropout Rate with Oral Antifungal Treatments
Authors: Iozumi Ken , Hattori Naoko , Adachi Makoto , Kaneko Takehiko , Shimozuma Michiro , Tamaki Kunihiko 
Published: July 2014

AbstractThe “complete cure” of onychomycosis requires long‐term treatment with a systemic antifungal agent. Therefore, to properly assess the effects of an antifungal agent on onychomycosis requires a long follow‐up. We have conducted a retrospective analysis of the patients treated with griseofulvin (GRF) from 1962 to 1992 and a clinical study to compare the long‐term effect of GRF with that of a new oral antifungal agent, itraconazole (ITCZ), for patients who received treatment from 1992 to 1995. For the retrospective study, 281 patients who were microscopically diagnosed as having onychomycosis at the Department of Dermatology, Faculty of Medicine, University of Tokyo, and received GRF administration in 1962, 1972, 1982, and 1992, were evaluated for cure rate and dropout rate. The total cure rate was 29.2%, but the cure rate was 68.8% for the patients who continued their medication for more than one year. For the comparative study, 139 patients who received the treatment at the same institution between 1992 and 1995 were evaluated. The cure rate and the dropout rate for GRF were found to be 23.8% (23/97) and 52.6% (51/97) respectively. The cure rate and the dropout rate for ITCZ were found to be 50.0% (21/42) and 38.1% (15/42). When the two treatment protocols were compared for their long‐term effects, we found that most of the patients treated with ITCZ were cured within 3 years, and about 30% of the patients treated with GRF remained uncured even after long‐term administration of the agent. Furthermore, from a multiple regression analysis, the GRF/ITCZ administration required to cure onychomycosis was estimated to be 3.92 + 0.161 [Age (years)] + 0.635 [Number of infected toenails] months. The results of this study suggest that the biggest problem associated with the treatment of onychomycosis with an oral antifungal agent is compliance in long‐term therapy. Notably, the final cure rate of ITCZ therapy went over 90%, suggesting that the low dose continuous therapy, the standard treatment protocol in Japan, was a key contributing factor for the higher cure rate for ITCZ.
Recessive Epidermolysis Bullosa Dystrophicans (Hallopeau‐Siemens)—Improvement of Wound Healing by Autologous Epidermal Grafts on an Esterified Hyaluronic Acid Membrane
Authors: Wollina Uwe , Konrad Helga , Fischer Tobias 
Published: July 2014

AbstractEpidermolysis bullosa dystropicans of the Hallopeau‐Siemens type (HS‐EBD) is an autosomal‐recessive blistering disease. Skin fragility due to mutations in structural proteins is responsible for further development of chronic and painful wounds, skin infections and sepsis. There is no causative treatment available. We present a case report with HS‐EBD and longstanding painful wounds treated with autologous keratinocytes on an esterified hyaluronic acid membrane. Two out of three wounds treated showed a complete take of the graft. They improved markedly with a stable result over 12 months until now. Even autologous keratinocyte grafting may have a beneficial effect on chronic wounds in HS‐EBD despite the fact that the genetic defects are unchanged.
Plantar Verrucous Carcinoma: Report of a Case Treated with Boyd Amputation Followed by Reconstruction with a Free Forearm Flap
Authors: Yoshitatsu Sumiko , Takagi Tadashi , Ohata Chika , Kozuka Takehito 
Published: July 2014

AbstractVerrucous carcinoma is a relatively rare, well‐differentiated, squamous cell carcinoma. Although it is slow‐growing and mimics benign skin leasions, it can cause extensive local destruction that necessitates amputation. It is often underdiagnosed as a benign tumor in its early course. We report a case of extensive verrucous carcinoma on a recalcitrant ulcer and a severe long‐standing scar around it on the sole of the right forefoot, which had been treated as a benign tumor for more than two years. We treated it successfully with amputation of the foot and were able to spare the heel by using a free innervated forearm flap to cover the defect at the stump. The present case should remind clinicians that a verrucous lesion developing on a refractory ulcer may be a complex malignant neoplasm; an accurate diagnosis is difficult without a combination of clinical features and pathological findings from an adequately deep specimen.
Reduction of Serum Interleukin‐5 Levels Reflect Clinical Improvement in Patients with Atopic Dermatitis
Authors: Kondo Seiji , Yazawa Hitoshi , Jimbow Kowichi 
Published: July 2014

AbstractCytokines, in particular IL‐4 and IL‐5, regulate IgE synthesis and eosinophil activation in atopic dermatitis (AD). To elucidate whether the serum levels of IL‐4 and IL‐5 are related to the serum IgE level, eosinophilia, or clinical severity of the disease, 25 cases with AD were studied. Blood samples were isolated from two groups of donors: 1) patients with AD (n=25); 2) non‐allergic individuals (NA, n=20) with serum IgE levels below 100 IU/ml and with blood eosinophil counts below 250/μl. Each parameter was evaluated at least twice in AD patients at the beginning of the study and after 4, 8 or 12 weeks of treatment. IL‐4 was hardly detected in AD and NA, but IL‐5 was increased (>10 pg/ml) in most cases (22/25) of AD group with 513.6 pg/ml as the mean. AD with normal serum IgE levels exhibited increased levels of IL‐5, whereas AD with high serum IgE levels did not necessarily have elevated IL‐5 levels. The IL‐5 level tended to change in parallel with the clinical severity in each AD case, although the level itself was not correlated with the clinical severity per se. A significant decrease of IL‐5 was observed in AD when the clinical severity decreased. Eosinophils also decreased along with the improvement of AD, whereas the serum level of IgE did not change during the observation period. Our results suggest that IL‐5 is involved in the regulation of clinical courses of AD and that its kinetics at the serum level reflects the clinical activity of AD.
Acute Urticaria with Elevated Circulating Interleukin‐6 Is Resistant to Anti‐Histamine Treatment
Authors: Fujii Kimio , Konishi Kenji , Kanno Yuko , Ohgou Noriko 
Published: July 2014

AbstractHistamine released from dermal mast cells plays a central role in the increased vascular permeability in acute urticaria, and administration of anti‐histamines usually suppresses development of wheals. Acute idiopathic urticaria, particularly a severe case, occasionally presents with acute inflammatory reactions such as low‐grade fever and leukocytosis and is resistant to anti‐histamines. Considering the wide spectrum of proinflammatory cytokines and chemokines that can be released from activated mast cells, some of them might be involved in the pathogenesis of urticaria. We measured plasma levels of interleukin‐6 (IL‐6), interleukin‐8 (IL‐8), and tumor necrosis factor‐α (TNF‐α) in 16 cases of severe acute urticaria. None of them showed elevated plasma levels of IL‐8 or TNF‐α. Nine out of 16 acute urticaria patients showed elevated circulating IL‐6 with concomitant increases in serum CRP levels. All such patients were resistant to conventional anti‐histamine treatment and required systemic steroids for complete suppression of wheal development. After subsidence of the urticaria, their elevated IL‐6 and CRP levels dropped to their normal ranges. In contrast, all but one patient without elevated circulating IL‐6 was successfully treated with a H1 receptor antagonist, cetirizine. The data suggest involvement of IL‐6 in the pathogenesis of severe acute urticaria that is resistant to anti‐histamines.
Generalized Hyperpigmentation of the Skin due to Vitamin B12 Deficiency
Authors: Mori Katsunori , Ando Iwao , Kukita Atsushi 
Published: July 2014

AbstractA 49‐year‐old man presented with neurosis, hyperpigmentation of the skin, and depigmentation of the hair. On examination, hyperpigmentation was observed on the oral mucosa and the skin of the forearms, elbows, palmar creases and periunguinal area, knees, and feet. He had megaloblastic anemia with a low serum level of vitamin B12 due to malabsorption resulting from a gastrectomy 10 years previously. His hyperpigmentation was resolved with vitamin B12 supplementation. Histology showed an increase of melanin in the basal layer. In electron microscopic study, many melanosomes were observed in melanocytes and surrounding keratinocytes. We consider that the dominant mechanism of hyperpigmentation due to vitamin B12 deficiency is not a defect in melanin transport but is rather an increase in melanin synthesis.
The Significance of Mast Cells Associated with Basal Cell Carcinoma
Authors: Erkiliç Suna , Erbağci Zülal 
Published: July 2014

AbstractIn the stroma of basal cell carcinoma (BCC), the numbers of mast cells are increased, but their significance remains unknown. In a retrospective histological study of 74 cases, we investigated the significance of mast cells related to BCC and the possible relationship between increased numbers of mast cells and clinical and histological parameters including the patients' age, sex, subtype of BCC, and severity of peritumoral inflammation. We found a significant increase in peritumoral mast cell numbers over those in uninvolved skin (p<0.0001). Morpheaform BCCs had significantly more mast cells than did the other variants (p=0.047). No significant relationship was found between mast cell number and the degree of peritumoral inflammation, patient age, or gender. Our results support previous reports indicating that mast cell numbers are increased in BCC, particularly in its morphoeic variant, implying a contributory role for mast cells in the aggressiveness of BCC.
Lipodystrophia Centrifugalis Abdominalis Infantilis: Two Cases from China
Authors: Kam‐har Mak , Hing‐fung Ho , Lio‐yuen Chan , Lai‐yin Chong 
Published: July 2014

AbstractWe report the first two Chinese patients with lipodystrophia centrifugalis abdominalis infantilis in China. The first patient was a 3‐year‐old girl who developed an area of hyperpigmented skin depression on the right groin which spread centrifugally to the abdomen and right lower chest. Later, another lesion developed on the neck. The second patient was a 4‐year‐old girl who developed multiple areas of skin depression on her bilateral groin, periumbilical region, right axilla, and chest. The lesions also extended centrifugally. Erythematous margins and lymphadenopathy were present in both cases. Inflammatory changes were found in the subcutaneous fat. The clinical pictures and histologic features supported the diagnosis of LCAI in both cases.
Hair Follicle Nevus Occurring in Frontonasal Dysplasia: An Electron Microscopic Observation
Authors: Kuwahara Hiroaki , Lao Li‐Min , Kiyohara Takahiro , Kumakiri Masanobu , Igawa Hiroharu 
Published: July 2014

AbstractWe report a rare hair follicle nevus that occurred in a three‐month‐old Japanese boy with mild frontonasal dysplasia. It had been present since birth. Histologically, numerous tiny vellus hair follicles were found within the dermis. The constituent cells of these follicles showed the features of follicular germ cells under the electron microscope. The fibroblasts around the follicles were active and merged with the colloid substance. Many myofibroblasts were found in a collagenous stroma in the atrophic lesion of the frontonasal dysplasia.
A Case of Folliculitis Decalvans Involving the Beard, Face and Nape
Authors: Karakuzu Ali , Erdem Teoman , Aktas Akin , Atasoy Mustafa , Gulec A. Ihsan 
Published: July 2014

AbstractFolliculitis decalvans is a rare and chronic progressive hair disorder leading to scarring alopecia and atrophy. Its etiology is still unclear. It starts with areas of perifollicular erythema, and follicular papules and pustules spread peripherally, leaving central scarred patches of alopecia. We report a 27‐year‐old man who presented with folliculitis decalvans involving the scalp, face, nape, and beard. There were pustules, crusts, and scarring alopecia on the scalp and beard.
Therapeutic Effects of Antibacterial Treatment for Intractable Skin Diseases in Helicobacter pylori‐Positive Japanese Patients
Authors: Sakurane Mikihisa , Shiotani Akiko , Furukawa Fukumi 
Published: July 2014

AbstractIn order to understand the pathogenic relationship between Helicobacter pylori (H. pylori) and skin diseases, we examined the serum levels of IgG antibody against H. pylori and then performed gastroscopic examinations in Japanese patients with chronic skin diseases. These H. pylori‐positive patients were treated with antibacterial eradication therapy, and therapeutic efficacy was evaluated. A total of 198 patients who were resistant to conventional therapies were randomly selected. They included 50 cases with chronic urticaria, 32 with pruritus cutaneous, 74 with atopic dermatitis, 15 with nummular dermatitis, 17 with prurigo chronica multiformis, 6 with psoriasis vulgaris, and 4 with erythroderma. Positive anti‐H. pylori antibody was detected in 102 out of these 198 patients; more than half of the ones with chronic urticaria, pruritus cutaneous, nummular dermatitis, and prurigo chronica multiformis had positive antibodies. Gastroscopy was then performed in 48 cases with positive antibodies. Eradication therapy was effective in 60% of the patients with chronic urticaria, in 58% with pruritus cutaneous, in 54% with nummular dermatitis, and in 50% with prurigo chronica multiformis. In chronic skin diseases, persistent infection with H. pylori may be an eruption trigger and may cause deterioration of the disease into an intractable and chronic form.
Cutaneous Manifestations in Childhood Staphylococcal Sepsis
Authors: Çaksen Hüseyin , Üzüm Kazim , Yüksel Şaban , Üstünbaş Hasan Basri 
Published: July 2014

AbstractIn this article, the clinical and laboratory findings of six (15%) cases of cutaneous manifestations of 39 patients with sepsis caused by Staphylococcus aureus (S. aureus) were reviewed retrospectively. Our purpose was to determine the cutaneous manifestations in patients with sepsis caused by S. aureus. In our study, four patients had maculopapular and/or petechial/purpuric rashes, and two had erythematous lesions (one of them also had pustular lesions, and the other had furuncles). Aside from these, all patients had one or more systemic involvement such as bronchopneumonia, arthritis, osteomyelitis, or cardiac involvement. In conclusion, our findings suggest that there are no skin findings specific to staphylococcal sepsis and that pulmonary infections appear to have a high correlation with cutaneous findings, because all of our patients had evidence of bronchopneumonia. The mortality of staphylococcal sepsis associated with cutaneous findings appears to be high.
Clinicopathologic Analysis of 66 Cases of Erythema Annulare Centrifugum
Authors: Kim Kyoung Jin , Chang Sung Eun , Choi Jee Ho , Sung Kyung Jeh , Moon Kee Chan , Koh Jai Kyoung 
Published: July 2014

AbstractErythema annulare centrifugum (EAC) denotes a group of eruptions characterized by slowly migrating annular or configurate erythematous lesions. It can be classified histopathologically as the deep or superficial type. Although there are many case reports of EAC associated with various underlying conditions, no recent clinicopathologic studies exist. The purpose of this study was aimed at analyzing the clinical and histopathologic features of EAC. Sixty‐six patients who have been diagnosed as EAC by clinical and histopathological examination were collected. The medical records and skin biopsy specimens of these patients were reviewed retrospectively. There were 24 male patients and 42 female ones. The mean age was 39.7 years, and the mean durtion of the disease was 2.8 years. The lower extremities, particularly the thigh, were the most frequently involved locations. The most common clinical manifestation was large (>1 cm), scaly, erythematous, indurated plaques. Forty‐eight patients (72%) had combined diseases including cutaneous fungal infection (48%), such as tinea pedis, other skin diseases (18%), internal malignancies (13%), and other systemic diseases (21%). By histopathologic examination, 33 of 42 patients (78%) were identified as superficial type, and 9 patients (22%) were deep type. Therapeutic trials with systemic or topical corticosteroid and oral antihistamine did not affect the chronic and recurrent course of these patients. EAC is a chronic and recurrent disease despite treatment. EAC is thought to be highly associated with internal disease as well as with superificial fungal infection. However, it was difficult to prove a causal association. The recognition and exact diagnosis of EAC is important, because it may be a quite stressful condition and lead to unnecessary over‐treatments.
One Confirmed and Six Suspected Cases of Cutaneous Larva Migrans Caused by Overseas Infection with Dog Hookworm Larvae
Authors: Nakamura‐Uchiyama Fukumi , Yamasaki Emi , Nawa Yukifumi 
Published: July 2014

AbstractCutaneous larva migrans (CLM) is characterized as creeping eruption/serpiginous erythema and/or mobile erythematous induration on the skin. In Japan, Gnathostoma spp. are the most well known pathogens causing CLM, especially the creeping eruption type. Recently, Spirurina type X larvae have been added to the list of causative agents for creeping eruption in Japan. Here we report one confirmed and 6 suspected cases of creeping eruption caused by infection with dog hookworm larvae. The patients were assumed to have been infected overseas. Dog hookworms such as Ancylostoma caninum and A. brasiliense should be considered as possible causative agents for creeping eruption, especially when the patients have a history of travelling overseas.
A Case of Angiosarcoma of the Nose
Authors: Nishiwaki Yoko , Tada Yurie , Nakatani Chie , Yamashina Yukio , Shirai Toshihiko , Miyagawa Sachiko 
Published: July 2014

AbstractA case of angiosarcoma arising from the nose of a 69‐year‐old man is presented in this report. The patient was treated with a combination of recombinant interleukin‐2 (rIL‐2, Celeuk®), electron beam irradiation, and surgery. He died 27 months after diagnosis, but there was no apparent remote metastasis.