bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Antecedents and Performance Consequences of Proactive Environmental Strategy: A Meta-analytic Review of National Contingency
Authors: Liu Yi , Guo Jingzhou , Chi Nan 
Published: July 2015

ABSTRACTIn this article we provide a comprehensive framework to explain, in China and in Western countries, how three antecedents – regulations, stakeholder norms, and managerial mindsets – differently affect proactive environmental strategies (PES) and subsequently influence firm performance. A meta-analysis of 68 studies involving 71 samples supports our hypotheses. In Western countries, top managerial mindsets have the strongest effect and regulations have the weakest effect on PES. In China, regulations, stakeholder norms, and managerial mindsets have similar effects on PES. For Western firms, the PES has stronger effects on environmental performance than on economic performance and the effect on environmental performance is stronger than that in Chinese firms. For firms in China, the PES has equally positively affects on environmental and economic performance, but the effect on economic performance is stronger than that of Western firms. Implications for future research are discussed.
Mercury anomalies associated with three extinction events (Capitanian Crisis, Latest Permian Extinction and the Smithian/Spathian Extinction) in NW Pangea
Authors: GRASBY STEPHEN E. , BEAUCHAMP BENOIT , BOND DAVID P.G. , WIGNALL PAUL B. , SANEI HAMED 
Published: July 2015

AbstractStrata of Permian – Early Triassic age that include a record of three major extinction events (Capitanian Crisis, Latest Permian Extinction and the Smithian/Spathian Extinction) were examined at the Festningen section, Spitsbergen. Over thec. 12 Ma record examined, mercury in the sediments shows relatively constant background values of 0.005–0.010 μg g–1. However, there are notable spikes in Hg concentration over an order of magnitude above background associated with the three extinctions. The Hg/total organic carbon (TOC) ratio shows similar large spikes, indicating that they represent a true increase in Hg loading to the environment. We argue that these represent Hg loading events associated with enhanced Hg emissions from large igneous province (LIP) events that are synchronous with the extinctions. The Hg anomalies are consistent across the NW margin of Pangea, indicating that widespread mercury loading occurred. While this provides utility as a chemostratigraphic marker the Hg spikes may also indicate loading of toxic metals to the environment, a contributing cause to the mass extinction events.
Small cell neuroendocrine carcinoma of larynx: case series and literature review
Authors: Iqbal Muhammad Shahid , Paleri V , Moor J , Dobrowsky W , Kelly C , Kovarik J 
Published: July 2015

AbstractBackground:Primary small cell neuroendocrine carcinoma of larynx is a rare, aggressive type of malignancy. As only about 200 cases worldwide have been reported, any larger institutional experience is valuable. This study reports our experience in managing this rare entity.Methods:Of the nine patients identified, three had metastatic cancer at the time of diagnosis. Four patients underwent radical treatment: one was managed surgically followed by adjuvant chemotherapy and consolidation radiotherapy; the remaining three were treated with neoadjuvant chemotherapy and definitive radiotherapy.Results:Of the 4 patients treated with radical intent, 1 was alive and disease free after 99 months, 2 died of metastatic disease after 22 and 26 months, and 1 was alive after 20 months with a diagnosis of recurrent disease.Conclusion:Our relatively small number of patients confirms other centres' experiences. This cancer has a poorer prognosis than most other head and neck cancers. Although the logistics would be challenging, there is a need for international multicentre trials for this disease modelled on those performed for other cancers, as has been done for paediatric malignancies.
Circulating and disseminated tumour cells in head and neck cancer
Authors: Harris A T , Derbyshire S , Wilson J , Loh C , Kinshuck A J , Attlmayr B , Jones T M 
Published: July 2015

AbstractBackground:Multimodal treatment options in head and neck squamous cell carcinoma have allowed for greater control of locoregional disease, but this has not translated into a significant overall survival advantage for patients. This is partially because these treatment modalities have no influence over the rate of development of distant metastases.Objective:This article summarises the current methods of detecting circulating and disseminated tumour cells. It also discusses how these cells can offer prognostic value in head and neck squamous cell carcinoma, and considers questions posed by the identification of these cells.Methods:A literature search of relevant journal articles was performed using ScienceDirect and PubMed databases, and a general article search was conducted using the online search engine Google.Results and conclusion:The evidence presented in this article indicates that circulating tumour cells and disseminated tumour cells may be clinically useful as prognostic markers or in the assessment of response to treatment in head and neck squamous cell carcinoma.
Familial risk for distress and fear disorders and emotional reactivity in adolescence: an event-related potential investigation
Authors: Nelson B. D. , Perlman G. , Hajcak G. , Klein D. N. , Kotov R. 
Published: July 2015

BackgroundThe late positive potential (LPP) is an event-related potential component that is sensitive to the motivational salience of stimuli. Children with a parental history of depression, an indicator of risk, have been found to exhibit an attenuated LPP to emotional stimuli. Research on depressive and anxiety disorders has organized these conditions into two empirical classes: distress and fear disorders. The present study examined whether parental history of distress and fear disorders was associated with the LPP to emotional stimuli in a large sample of adolescent girls.MethodThe sample of 550 girls (ages 13.5–15.5 years) with no lifetime history of depression completed an emotional picture-viewing task and the LPP was measured in response to neutral, pleasant and unpleasant pictures. Parental lifetime history of psychopathology was determined via a semi-structured diagnostic interview with a biological parent, and confirmatory factor analysis was used to model distress and fear dimensions.ResultsParental distress risk was associated with an attenuated LPP to all stimuli. In contrast, parental fear risk was associated with an enhanced LPP to unpleasant pictures but was unrelated to the LPP to neutral and pleasant pictures. Furthermore, these results were independent of the adolescent girls’ current depression and anxiety symptoms and pubertal status.ConclusionsThe present study demonstrates that familial risk for distress and fear disorders may have unique profiles in terms of electrocortical measures of emotional information processing. This study is also one of the first to investigate emotional/motivational processes underlying the distress and fear disorder dimensions.
The impact of childhood adversity on the persistence of psychotic symptoms: a systematic review and meta-analysis
Authors: Trotta A. , Murray R. M. , Fisher H. L. 
Published: July 2015

BackgroundEvidence suggests that childhood adversity is associated with the development of psychotic experiences (PE), psychotic symptoms and disorders. However, less is known regarding the impact of early adversity on the persistence of PE and clinically relevant psychosis. Thus we conducted a systematic review of the association between childhood adversity and the course of PE and symptoms over time.MethodA systematic search of Medline, EMBASE and PsychINFO databases was undertaken to identify articles published between January 1956 and November 2014. We included studies conducted on general population samples, individuals at ultra-high risk (UHR) of psychosis, and patients with full-blown psychotic disorders. A meta-analysis was performed on a subgroup.ResultsA total of 20 studies were included. Of these, 17 reported positive associations between exposure to overall or specific subtypes of childhood adversity and persistence of PE or clinically relevant psychotic symptoms. A meta-analysis of nine studies yielded a weighted odds ratio of 1.76 [95% confidence interval (CI) 1.19–2.32,p< 0.001] for general population studies and 1.55 (95% CI 0.32–2.77,p= 0.007) for studies conducted using clinical populations.ConclusionsThe available evidence is limited but tentatively suggests that reported exposure to adverse events in childhood is associated with persistence of PE and clinically relevant psychotic symptoms. This partially strengthens the case for addressing the consequences of early adversity in individuals presenting with psychotic phenomena to improve long-term outcomes. However, the heterogeneity of studies was high which urges caution in interpreting the results and highlights the need for more methodologically robust studies.
Hippocampal volume change relates to clinical outcome in childhood-onset schizophrenia
Authors: Anvari A. A. , Friedman L. A. , Greenstein D. , Gochman P. , Gogtay N. , Rapoport J. L. 
Published: July 2015

BackgroundFixed hippocampal volume reductions and shape abnormalities are established findings in schizophrenia, but the relationship between hippocampal volume change and clinical outcome has been relatively unexplored in schizophrenia and other psychotic disorders. In light of recent findings correlating hippocampal volume change and clinical outcome in first-episode psychotic adults, we hypothesized that fewer decreases in hippocampal volume would be associated with better functional outcome and fewer psychotic symptoms in our rare and chronically ill population of childhood-onset schizophrenia (COS) patients.MethodWe prospectively obtained 114 structural brain magnetic resonance images (MRIs) from 27 COS subjects, each with three or more scans between the ages of 10 and 30 years. Change in hippocampal volume, measured by fit slope and percentage change, was regressed against clinical ratings (Children's Global Assessment Scale, Scale for the Assessment of Positive Symptoms, Scale for the Assessment of Negative Symptoms) at last scan (controlling for sex, time between scans and total intracranial volume).ResultsFewer negative symptoms were associated with less hippocampal volume decrease (fit slope: p = 0.0003, and percentage change: p = 0.005) while positive symptoms were not related to hippocampal change. There was also a relationship between improved clinical global functioning and maintained hippocampal volumes (fit slope: p = 0.025, and percentage change: p = 0.043).ConclusionsThese results suggest that abnormal hippocampal development in schizophrenia can be linked to global functioning and negative symptoms. The hippocampus can be considered a potential treatment target for future therapies.
Severity of depressive symptoms as a predictor of mortality: the English longitudinal study of ageing
Authors: White J. , Zaninotto P. , Walters K. , Kivimäki M. , Demakakos P. , Shankar A. , Kumari M. , Gallacher J. , Batty G. D. 
Published: July 2015

BackgroundMajor depressive disorder and subthreshold depression have been associated with premature mortality. We investigated the association between depressive symptoms and mortality across the full continuum of severity.MethodWe used Cox proportional hazards models to examine the association between depressive symptom severity, assessed using the eight-item Center for Epidemiological Studies Depression Scale (CES-D; range 0–8), and the risk of all-cause mortality over a 9-year follow-up, in 11 104 members of the English Longitudinal Study of Ageing.ResultsDuring follow-up, one fifth of study members died (N = 2267). Depressive symptoms were associated with increased mortality across the full range of severity (ptrend < 0.001). Relative to study members with no symptoms, an increased risk of mortality was found in people with depressive symptoms of a low [hazard ratio (HR) for a score of 2 was 1.59, 95% confidence interval (CI) 1.40–1.82], moderate (score of 4: HR 1.80, 95% CI 1.52–2.13) and high (score of 8: HR 2.27, 95% CI 1.69–3.04) severity, suggesting risk emerges at low levels but plateaus thereafter. A third of participants (36.4%, 95% CI 35.5–37.3) reported depressive symptoms associated with an increased mortality risk. Adjustment for physical activity, physical illnesses, and impairments in physical and cognitive functioning attenuated this association (ptrend = 0.25).ConclusionsDepressive symptoms are associated with an increased mortality risk even at low levels of symptom severity. This association is explained by physical activity, physical illnesses, and impairments in physical and cognitive functioning.
The algebra of parallel endomorphisms of a pseudo-Riemannian metric: semi-simple part
Authors: BOUBEL CHARLES 
Published: July 2015

AbstractOn a (pseudo-)Riemannian manifold (${\mathcal M}$, g), some fields of endomorphisms i.e. sections of End(T${\mathcal M}$) may be parallel for g. They form an associative algebra $\mathfrak e$, which is also the commutant of the holonomy group of g. As any associative algebra, $\mathfrak e$ is the sum of its radical and of a semi-simple algebra $\mathfrak s$. Here we study $\mathfrak s$: it may be of eight different types, including the generic type $\mathfrak s$ = ${\mathbb R}$ Id, and the Kähler and hyperkähler types $\mathfrak s$ ≃ ${\mathbb C}$ and $\mathfrak s$ ≃ ${\mathbb H}$. This is a result on real, semi-simple algebras with involution. For each type, the corresponding set of germs of metrics is non-empty; we parametrize it. We give the constraints imposed to the Ricci curvature by parallel endomorphism fields.
Primitive submodules for Drinfeld modules
Authors: KUO WENTANG , TWEEDLE DAVID 
Published: July 2015

AbstractThe ring A = $\mathbb{F}$r[T] and its fraction field k, where r is a power of a prime p, are considered as analogues of the integers and rational numbers respectively. Let K/k be a finite extension and let φ be a Drinfeld A-module over K of rank d and Γ ⊂ K be a finitely generated free A-submodule of K, the A-module structure coming from the action of φ. We consider the problem of determining the number of primes ℘ of K for which the reduction of Γ modulo ℘ is equal to $\mathbb{F}$℘ (the residue field of the prime ℘). We can show that there is a natural density of primes ℘ for which Γ mod ℘ is equal to $\mathbb{F}$℘. In certain cases, this density can be seen to be positive.
PLK1 regulates spindle formation kinetics and APC/C activation in mouse zygote
Authors: Baran Vladimir , Brzakova Adela , Rehak Pavol , Kovarikova Veronika , Solc Petr 
Published: July 2015

SummaryPolo-like kinase 1 (PLK1) is involved in essential events of cell cycle including mitosis in which it participates in centrosomal microtubule nucleation, spindle bipolarity establishment and cytokinesis. Although PLK1 function has been studied in cycling cancer cells, only limited data are known about its role in the first mitosis of mammalian zygotes. During the 1-cell stage of mouse embryo development, the acentriolar spindle is formed and the shift from acentriolar to centrosomal spindle formation progresses gradually throughout the preimplantation stage, thus providing a unique possibility to study acentriolar spindle formation. We have shown previously that PLK1 activity is not essential for entry into first mitosis, but is required for correct spindle formation and anaphase onset in 1-cell mouse embryos. In the present study, we extend this knowledge by employing quantitative confocal live cell imaging to determine spindle formation kinetics in the absence of PLK1 activity and answer the question whether metaphase arrest at PLK1-inhibited embryos is associated with low anaphase-promoting complex/cyclosome (APC/C) activity and consequently high securin level. We have shown that inhibition of PLK1 activity induces a delay in onset of acentriolar spindle formation during first mitosis. Although these PLK1-inhibited 1-cell embryos were finally able to form a bipolar spindle, not all chromosomes were aligned at the metaphase equator. PLK1-inhibited embryos were arrested in metaphase without any sign of APC/C activation with high securin levels. Our results document that PLK1 controls the onset of spindle assembly and spindle formation, and is essential for APC/C activation before anaphase onset in mouse zygotes.
Cryostat Slice Irregularities May Introduce Bias in Tissue Thickness Estimation: Relevance for Cell Counting Methods
Authors: Puigdellívol-Sánchez Anna , Giralt Albert , Casanovas Anna , Alberch Jordi , Prats-Galino Alberto 
Published: July 2015

AbstractStereological techniques using the optical disectors require estimation of final section thickness, but frozen tissue irregularities may interfere with this estimation. Cryostat slices from rodent nerve tissues (dorsal root ganglia, spinal cord, and brain), cut at 16, 40, and 50 μm, were digitized with a confocal microscope and visualized through 3D software. Geometric section thickness of tissue (Tgeom) was defined as tissue volume/area. Maximal section thicknesses (Tmax), from the top to the bottom of the section, were measured in a random sample of vertical ZX planes. Irregularities were mostly related to blood vessels traversing the tissue and neuronal somas protruding over the cut surfaces, with other neuron profiles showing a fragmented appearance. Irregularities contributed to increasing the distance between the tops and bottoms of slices sectioned in different laboratories. Significant differences were found between Tmax and Tgeom for all thickness studies and counting frames (p<0.01). The Tgeom/Tmax average rate was 68.4–85.7% in volumes around cell profiles (∼600–1,200 μm2) and 83.3–91.8% in subcellular samples (∼25–160 μm2). Confocal microscopy may help to assess tissue irregularities, which might lead to an overestimation of tissue volume if section thickness is estimated by focusing on the top and bottom of the sections.
Sequence-related amplified polymorphism and inter-simple sequence repeat marker-based genetic diversity and nuclear DNA content variation in common vetch (Vicia sativaL.)
Authors: Cil Abdullah , Tiryaki Iskender 
Published: July 2015

Genetic diversity of 30 common vetch (Vicia sativaL.) lines and cultivars obtained from various resources or collected from natural flora of Turkey was evaluated by using 55 sequence-related amplified polymorphism (SRAP) and five inter-simple sequence repeat (ISSR) primer sets, and their nuclear DNA contents were determined by flow cytometer. A total of 188 polymorphic loci were detected, with an average of 3.62 loci per primer. The percentage of polymorphic loci was 82.1%. The polymorphism information content values ranged from 0.12 to 0.96, with an average of 0.63. The genetic distance coefficients were in the range of 0.112–0.627. Cluster analysis revealed that the 27 lines and three cultivars could be divided into two main groups. No polyploidy was detected within any vetch lines tested while significant (P< 0.0001) nuclear DNA content differences were determined. The present study revealed that fast and accurate fingerprinting analysis could be done using SRAP and ISSR markers, which indicated existing significant variation among common vetch lines and cultivars.
Restoration of rhythmicity in diffusively coupled dynamical networks
Authors: Zou Wei , Senthilkumar D. V. , Nagao Raphael , Kiss István Z. , Tang Yang , Koseska Aneta , Duan Jinqiao , Kurths Jürgen 
Published: July 2015

AbstractOscillatory behaviour is essential for proper functioning of various physical and biological processes. However, diffusive coupling is capable of suppressing intrinsic oscillations due to the manifestation of the phenomena of amplitude and oscillation deaths. Here we present a scheme to revoke these quenching states in diffusively coupled dynamical networks, and demonstrate the approach in experiments with an oscillatory chemical reaction. By introducing a simple feedback factor in the diffusive coupling, we show that the stable (in)homogeneous steady states can be effectively destabilized to restore dynamic behaviours of coupled systems. Even a feeble deviation from the normal diffusive coupling drastically shrinks the death regions in the parameter space. The generality of our method is corroborated in diverse non-linear systems of diffusively coupled paradigmatic models with various death scenarios. Our study provides a general framework to strengthen the robustness of dynamic activity in diffusively coupled dynamical networks.
Plant species’ origin predicts dominance and response to nutrient enrichment and herbivores in global grasslands
Authors: Seabloom Eric W. , Borer Elizabeth T. , Buckley Yvonne M. , Cleland Elsa E. , Davies Kendi F. , Firn Jennifer , Harpole W. Stanley , Hautier Yann , Lind Eric M. , MacDougall Andrew S. , Orrock John L. , Prober Suzanne M. , Adler Peter B. , Anderson T. Michael , Bakker Jonathan D. , Biederman Lori A. , Blumenthal Dana M. , Brown Cynthia S. , Brudvig Lars A. , Cadotte Marc , Chu Chengjin , Cottingham Kathryn L. , Crawley Michael J. , Damschen Ellen I. , Dantonio Carla M. , DeCrappeo Nicole M. , Du Guozhen , Fay Philip A. , Frater Paul , Gruner Daniel S. , Hagenah Nicole , Hector Andy , Hillebrand Helmut , Hofmockel Kirsten S. , Humphries Hope C. , Jin Virginia L. , Kay Adam , Kirkman Kevin P. , Klein Julia A. , Knops Johannes M. H. , La Pierre Kimberly J. , Ladwig Laura , Lambrinos John G. , Li Qi , Li Wei , Marushia Robin , McCulley Rebecca L. , Melbourne Brett A. , Mitchell Charles E. , Moore Joslin L. , Morgan John , Mortensen Brent , O'Halloran Lydia R. , Pyke David A. , Risch Anita C. , Sankaran Mahesh , Schuetz Martin , Simonsen Anna , Smith Melinda D. , Stevens Carly J. , Sullivan Lauren , Wolkovich Elizabeth , Wragg Peter D. , Wright Justin , Yang Louie 
Published: July 2015

AbstractExotic species dominate many communities; however the functional significance of species’ biogeographic origin remains highly contentious. This debate is fuelled in part by the lack of globally replicated, systematic data assessing the relationship between species provenance, function and response to perturbations. We examined the abundance of native and exotic plant species at 64 grasslands in 13 countries, and at a subset of the sites we experimentally tested native and exotic species responses to two fundamental drivers of invasion, mineral nutrient supplies and vertebrate herbivory. Exotic species are six times more likely to dominate communities than native species. Furthermore, while experimental nutrient addition increases the cover and richness of exotic species, nutrients decrease native diversity and cover. Native and exotic species also differ in their response to vertebrate consumer exclusion. These results suggest that species origin has functional significance, and that eutrophication will lead to increased exotic dominance in grasslands.