bluuebunny/crossref_metadata_2025_split huggingface dataset:
Life satisfaction and mental health problems (18 to 35 years)
Authors: Fergusson D. M. , McLeod G. F. H. , Horwood L. J. , Swain N. R. , Chapple S. , Poulton R. 
Published: March 2015

BackgroundPrevious research has found that mental health is strongly associated with life satisfaction. In this study we examine associations between mental health problems and life satisfaction in a birth cohort studied from 18 to 35 years.MethodData were gathered during the Christchurch Health and Development Study, which is a longitudinal study of a birth cohort of 1265 children, born in Christchurch, New Zealand, in 1977. Assessments of psychiatric disorder (major depression, anxiety disorder, suicidality, alcohol dependence and illicit substance dependence) using DSM diagnostic criteria and life satisfaction were obtained at 18, 21, 25, 30 and 35 years.ResultsSignificant associations (p < 0.01) were found between repeated measures of life satisfaction and the psychiatric disorders major depression, anxiety disorder, suicidality, alcohol dependence and substance dependence. After adjustment for non-observed sources of confounding by fixed effects, statistically significant associations (p < 0.05) remained between life satisfaction and major depression, anxiety disorder, suicidality and substance dependence. Overall, those reporting three or more mental health disorders had mean life satisfaction scores that were nearly 0.60 standard deviations below those without mental health problems. A structural equation model examined the direction of causation between life satisfaction and mental health problems. Statistically significant (p < 0.05) reciprocal associations were found between life satisfaction and mental health problems.ConclusionsAfter adjustment for confounding, robust and reciprocal associations were found between mental health problems and life satisfaction. Overall, this study showed evidence that life satisfaction influences mental disorder, and that mental disorder influences life satisfaction.
Adopting trust and assurance as indicators for the reassignment of responsibilities in multi-agent systems
Authors: Gâteau Benjamin , Ouedraogo Moussa , Feltus Christophe , Guemkam Guy , Danoy Grégoire , Seredynski Marcin , Khan Samee U. , Khadraoui Djamel , Bouvry Pascal 
Published: March 2015

AbstractMulti-agent systems have been widely used in the literature, including for the monitoring of distributed systems. However, one of the unresolved issues in this technology remains in the reassignment of the responsibilities of monitoring agents when some of them become unable to meet their obligations. This paper proposes a new approach for solving this problem based on (a) the gathering of evidence on whether the agent can or cannot fulfil the tasks it has been assigned and (b) the reassignment of the task to alternative agents using their trust level as a selection parameter. A weather station case study is proposed as an instantiation of the proposed model.
Distributed aggregation of heterogeneous Web-based Fine Art Information: enabling multi-source accessibility and curation
Authors: Buchanan Frances , Capanni Niccolo , González-Vélez Horacio 
Published: March 2015

AbstractThe sources of information on the Web relating to Fine Art and in particular to Fine Artists are numerous, heterogeneous and distributed. Data relating to the biographies of an artist, images of their artworks, location of the artworks and exhibition reviews invariably reside in distinct and seemingly unrelated, or at least unlinked, sources. While communication and exchange exists, there is a great deal of independence between major repositories, such as museum, often owing to their ownership or heritage. This increases the individuality in the repository’s own processes and dissemination. It is currently necessary to browse through numerous different websites to obtain information about any one artist, and at this time there is little aggregation of Fine Art Information. This is in contrast to the domain of books and music, where the aggregation and re-grouping of information (usually by author or artist/band name) has become the norm. A Museum API (Application Programming Interface), however, is a tool that can facilitate a similar information service for the domain of Fine Art, by allowing the retrieval and aggregation of Web-based Fine Art Information, whilst at the same time increasing public access to the content of a museum’s collection. In this paper, we present the case for a pragmatic solution to the problems of heterogeneity and distribution of Fine Art Data and this is the first step towards the comprehensive re-presentation of Fine Art Information in a more ‘artist-centric’ way, via accessible Web applications. This paper examines the domain of Fine Art Information on the Web, putting forward the case for more Web services such as generic Museum APIs, highlighting this via a prototype Web application known as the ArtBridge. The generic Museum API is the standardisation mechanism to enable interfacing with specific Museum APIs.
Re-visioning Global Modernity through the Prism of China
Authors: Lu Sheldon 
Published: March 2015

This essay reviews and assesses recent attempts to revisit and revise the position of China in the configuration of global modernity. Such re-descriptions question the implicit Eurocentric teleology of modern world history. First, the discourse of East Asian modernity or Confucian capitalism draws on late imperial (early modern) East Asia to locate an alternative origin of global modernity. Second, recent scholarship in world-systems analysis repudiates previous Eurocentric narratives of global capitalism and locates China at the center of the world economy in the early modern period up to 1800. Third, China’s revolutionary legacy (what was called ‘Maoism’) and its current ‘socialism with Chinese characteristics’ in official parlance are considered by New Leftist theorists as a viable alternative to capitalist modernity. Fourth, universal modernity as such is regarded as a social and political imperative by the opposing camp of Neo-Liberalists as modernity is still an ‘incomplete project’ in Chinese history. Overall, such debates are efforts to chart out a cultural and theoretical landscape that does not easily fit in existing models of Western cultural studies that are often based on the colonial and postcolonial experiences of the Anglophone and Francophone world.Global modernity refers to a moment of the breakdown of the hegemony of a Eurocentric modernity and the fragmentation into many cultural spheres of the very idea of the modern without any promise so far of how modernity might be reconstituted and some coherence restored to its claims.... On the other hand, Global Modernity as a concept is also intended to transcend the situation of which it is the product, as this very situation enables the possibility of re-envisioning modernity, rescuing it from entrapment in a vision of history dominated by Eurocentrism and imagining it differently. (Arif Dirlik,Culture and History in Postrevolutionary China: The Perspective of Global Modernity)1
Cooking with soyabean oil increases whole-blood α-linolenic acid in school-aged children: results from a randomized trial
Authors: Villamor Eduardo , Marín Constanza , Mora-Plazas Mercedes , Casale Mia , Vargas Luz N , Baylin Ana 
Published: March 2015

AbstractObjectiveSupply of essentialn-3 PUFA is limited worldwide. While fish-oil supplementation effectively improvesn-3 PUFA status, it may not be a sustainable intervention. The use of α-linolenic acid (ALA)-rich cooking oils in the household may be a suitable alternative but its effect on PUFA status is unclear. We aimed to compare the effect of providing families with soyabean oil, an ALA-rich cooking oil,v. sunflower oil on whole-blood PUFA levels of children aged 11–18 years.DesignIn a randomized, masked, parallel trial, we assigned families to receive a one-month supply of either soyabean or sunflower oil. Fatty acid concentrations were quantified in whole-blood samples obtained from the children before and at the end of the intervention. Changes in fatty acids were compared between treatment arms with use of linear regression for repeated measures.SubjectsSixty low- and middle-income families.SettingBogotá, Colombia.ResultsSoyabean oil significantly increased ALA concentrations by 0·05 percentage points of total serum fatty acids whereas sunflower oil decreased them by 0·12 percentage points (soyabeanv. sunflower oil effect=0·17; 95 % CI 0·11, 0·24). Concentrations of bothn-3 andn-6 very-long-chain PUFA, including docosapentaenoic acid, DHA, dihomo-γ-linolenic acid and arachidonic acid, increased significantly in both intervention arms. Levels of oleic acid and palmitic acid decreased, irrespective of oil assignment. Total energy or energy intake from saturated fat did not change.ConclusionsReplacing cooking oils at the household level is an effective intervention to improve essential PUFA status of children.
Hydrophobic mismatch demonstrated for membranolytic peptides and their use as molecular rulers to measure bilayer thickness in native cells
Authors: Grau-Campistany Ariadna , Strandberg Erik , Wadhwani Parvesh , Reichert Johannes , Bürck Jochen , Rabanal Francesc , Ulrich Anne S. 
Published: March 2015

AbstractHydrophobic mismatch is a well-recognized principle in the interaction of transmembrane proteins with lipid bilayers. This concept was extended here to amphipathic membranolytic α-helices. Nine peptides with lengths between 14 and 28 amino acids were designed from repeated KIAGKIA motifs and their helical nature was confirmed by circular dichroism spectroscopy. Biological assays for antimicrobial activity and hemolysis, as well as fluorescence vesicle leakage and solid-state NMR spectroscopy, were used to correlate peptide length with membranolytic activity. These data show that the formation of transmembrane pores is only possible under the condition of hydrophobic matching: the peptides have to be long enough to span the hydrophobic bilayer core to be able to induce vesicle leakage, kill bacteria and cause hemolysis. By correlating the threshold lengths for biological activity with the biophysical results on model vesicles, the peptides could be utilized as molecular rulers to measure the membrane thickness in different cells.
Annexin V-induced rat Leydig cell proliferation involves Ect2 via RhoA/ROCK signaling pathway
Authors: Jing Jun , Chen Li , Fu Hai-Yan , Fan Kai , Yao Qi , Ge Yi-Feng , Lu Jin-Chun , Yao Bing 
Published: March 2015

AbstractThis study investigated the effect of annexin V on the proliferation of primary rat Leydig cells and the potential mechanism. Our results showed that annexin V promoted rat Leydig cell proliferation and cell cycle progression in a dose- and time-dependent manner. Increased level of annexin V also enhanced Ect2 protein expression. However, siRNA knockdown of Ect2 attenuated annexin V-induced proliferation of rat Leydig cells. Taken together, these data suggest that increased level of annexin V induced rat Leydig cell proliferation and cell cycle progression via Ect2. Since RhoA activity was increased following Ect2 activation, we further investigated whether Ect2 was involved in annexin V-induced proliferation via the RhoA/ROCK pathway and the results showed that annexin V increased RhoA activity too and this effect was abolished by the knockdown of Ect2. Moreover, inhibition of the RhoA/ROCK pathway by a ROCK inhibitor, Y27632, also attenuated annexin V-induced proliferation and cell cycle progression. We thus conclude that Ect2 is involved in annexin V-induced rat Leydig cell proliferation through the RhoA/ROCK pathway.
Investigating a new neuromodulation treatment for brain disorders using synchronized activation of multimodal pathways
Authors: Markovitz Craig D. , Smith Benjamin T. , Gloeckner Cory D. , Lim Hubert H. 
Published: March 2015

AbstractNeuromodulation is an increasingly accepted treatment for neurological and psychiatric disorders but is limited by its invasiveness or its inability to target deep brain structures using noninvasive techniques. We propose a new concept called Multimodal Synchronization Therapy (mSync) for achieving targeted activation of the brain via noninvasive and precisely timed activation of auditory, visual, somatosensory, motor, cognitive and limbic pathways. In this initial study in guinea pigs, we investigated mSync using combined activation of just the auditory and somatosensory pathways, which induced differential and timing dependent plasticity in neural firing within deep brain and cortical regions of the auditory system. Furthermore, by varying the location of somatosensory stimulation across the body, we increased or decreased spiking activity across different neurons. These encouraging results demonstrate the feasibility of systematically modulating the brain using mSync. Considering that hearing disorders such as tinnitus and hyperacusis have been linked to abnormal and hyperactive firing patterns within the auditory system, these results open up the possibility for using mSync to decrease this pathological activity by varying stimulation parameters. Incorporating multiple types of pathways beyond just auditory and somatosensory inputs and using other activation patterns may enable treatment of various brain disorders.
GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1
Authors: Kumar Krishan , Raza Sania S. , Knab Lawrence M. , Chow Christina R. , Kwok Benjamin , Bentrem David J. , Popovic Relja , Ebine Kazumi , Licht Jonathan D. , Munshi Hidayatullah G. 
Published: March 2015

AbstractJQ1 and I-BET151 are selective inhibitors of BET bromodomain proteins that have efficacy against a number of different cancers. Since the effectiveness of targeted therapies is often limited by development of resistance, we examined whether it was possible for cancer cells to develop resistance to the BET inhibitor JQ1. Here we show that pancreatic cancer cells developing resistance to JQ1 demonstrate cross-resistance to I-BET151 and insensitivity to BRD4 downregulation. The resistant cells maintain expression of c-MYC, increase expression of JQ1-target genes FOSL1 and HMGA2 and demonstrate evidence of epithelial-mesenchymal transition (EMT). However, reverting EMT fails to sensitize the resistant cells to JQ1 treatment. Importantly, the JQ1-resistant cells remain dependent on c-MYC that now becomes co-regulated by high levels of GLI2. Furthermore, downregulating GLI2 re-sensitizes the resistant cells to JQ1. Overall, these results identify a mechanism by which cancer cells develop resistance to BET inhibitors.
The effect of music performance on the transcriptome of professional musicians
Authors: Kanduri Chakravarthi , Kuusi Tuire , Ahvenainen Minna , Philips Anju K. , Lähdesmäki Harri , Järvelä Irma 
Published: March 2015

AbstractMusic performance by professional musicians involves a wide-spectrum of cognitive and multi-sensory motor skills, whose biological basis is unknown. Several neuroscientific studies have demonstrated that the brains of professional musicians and non-musicians differ structurally and functionally and that musical training enhances cognition. However, the molecules and molecular mechanisms involved in music performance remain largely unexplored. Here, we investigated the effect of music performance on the genome-wide peripheral blood transcriptome of professional musicians by analyzing the transcriptional responses after a 2-hr concert performance and after a ‘music-free’ control session. The up-regulated genes were found to affect dopaminergic neurotransmission, motor behavior, neuronal plasticity and neurocognitive functions including learning and memory. Particularly, candidate genes such asSNCA,FOSandDUSP1that are involved in song perception and production in songbirds, were identified, suggesting an evolutionary conservation in biological processes related to sound perception/production. Additionally, modulation of genes related to calcium ion homeostasis, iron ion homeostasis, glutathione metabolism and several neuropsychiatric and neurodegenerative diseases implied that music performance may affect the biological pathways that are otherwise essential for the proper maintenance of neuronal function and survival. For the first time, this study provides evidence for the candidate genes and molecular mechanisms underlying music performance.
Counterpoints about predatory open access and knowledge publishing in Africa
Authors: NWAGWU Williams Ezinwa 
Published: March 2015

ABSTRACTThe promise of open access (OA) as a replacement for existing scientific information dissemination ethos and practice has been contentious, with the interests of different stakeholders – countries, publishers, and OA activists, among others – clashing on an unprecedented scale. This paper examines some of the challenges that have been triggered by the OA movement, particularly at the Africa regional level. Basically, OA is technology heavy and its economic arrangements benefit mainly the developed world. There is evidence of OA initiatives in Africa, but these initiatives are mainly individually based, defragmented, and largely underdeveloped, and sometimes predatory. This author argues that policy‐makers in Africa need to embrace OA and establish useful policies – for regional journals and regional repositories and for academic reward, and support this with technical investment to enable quality online publishing.
How the role of the independent editor is changing in relation to traditional and self‐publishing
Authors: BAVERSTOCK Alison , BLACKBURN Robert , ISKANDAROVA Marfuga 
Published: March 2015

ABSTRACTThis paper reports on a survey of editors undertaken during 2013. The survey asked about lifestyle and work, and in particular how these are changing with the growth of self‐publishing authors. This article reports on the changing opportunities for editorial work and the practices of independent editors, and how their working routines have changed over the past three years. It reveals a shift from working for traditional publishers towards working for new clients, including self‐publishing authors; relationships with traditional publishers are strained for a variety of reasons, and increasing satisfaction levels are discernible in relationships with experienced self‐publishers. The paper considers the consequences of editors' changing patterns of work and client base, and likely future outcomes. Areas for further close monitoring and research are suggested.
The promise of post‐publication peer review: how do we get there from here?
Authors: WINKER Margaret 
Published: March 2015

Key points
Post‐publication peer review (PPPR) has not achieved its promise and potential.
Few articles receive PPPR – even those in high‐profile journals.
PPPR is difficult to find and needs to be linked to the original article.
Academics require recognition if they are to contribute their time to PPPR.
Improving PPPR would improve the scholarly corpus.
Genome-wide Association Study for Number of Vertebrae in an F2 Large White × Minzhu Population of Pigs
Authors: Zhang Longchao , Liu Xin , Liang Jing , Zhao Kebin , Yan Hua , Li Na , Pu Lei , Zhang Yuebo , Shi Huibi , Wang Ligang , Wang Lixian 
Published: March 2015

ABSTRACTPorcine carcass that is approximately 800 mm long may be expected to have one additional vertebra. Therefore, the number of vertebrae in pigs is an economically important trait. To examine the genetic basis of this trait, we genotyped 593 F2 Large White × Minzhu pigs using the Porcine SNP60K BeadChip. A genome-wide association study identified 39 significant single-nucleotide polymorphisms (SNPs) on the chromosomes SSC1 and SSC7. An 8.82-Mb region that contained all 21 significant SNPs on SSC1 harbored the geneNR6A1, previously reported to influence the number of vertebrae in pigs. The remaining 18 significant SNPs on SSC7 were concentrated in a 4.56-Mb region, which was within the quantitative trait loci interval for number of vertebrae. A haplotype sharing analysis refined the locus to a segment of ∼637 Kb. The most significant SNP, SIRI0001067, was contained in this refined region on SSC7 and located in one of the introns ofTGFB3. AsTGFB3influences the development of vertebrae in mammalian embryos, the gene may be another strong candidate for the number of vertebrae in pigs.
Unravelling causes of defects in construction
Authors: Jingmond Monika , Ågren Robert 
Published: March 2015

Purpose
– The purpose of this study is to identify the primary root causes of defects in terms of why they persist in construction, despite the increasing implementation of quality systems. Defects in construction continue to be a source of concern in the construction industry. There have been studies that have tried to identify causes of defects. Although concepts are usually related to organisational factors, previous studies have been carried out on an operational level. There is a well-trodden area within the literature relating to the operational level, but little is known about the causes of defects on a higher, organisational level within construction.

Design/methodology/approach
– A new approach based on the notion of process causality and the use of cognitive mapping has been adopted. The aim was to take a step back and unravel causes of defects in the execution of construction projects. From workshops with representatives drawn from different parts of the industry, themes have been identified and investigated from a causation perspective.

Findings
– It was found that the causes of defects mainly reside in endogenous factors within organisations as opposed to execution failure or exogenous factors related to market, material or equipment behaviour.

Originality/value
– More specifically, it was found that the dominant cause of defects lies within organisational shortcomings, suggesting that improvements can be found on the management and strategic levels within projects instead of on the operational level.
A hybrid SD–DES simulation approach to model construction projects
Authors: Moradi Saeed , Nasirzadeh Farnad , Golkhoo Farzaneh 
Published: March 2015

Purpose– The purpose of this research is to propose a hybrid simulation framework which can take into account both the continuous and operational variables affecting the performance of construction projects.Design/methodology/approach– System dynamics (SD) simulation paradigm is implemented for the modelling of the complex inter-related structure of continuous variables and discrete event simulation (DES) is implemented for the modelling of operational influencing factors. A hybrid modelling framework is then proposed through combination of SD and DES to simulate the construction projects.Findings– This paper discusses the deficiencies of two traditional simulation methods – SD and DES – for simulation of construction projects which can be compensated by implementing hybrid SD–DES model. Different types of basic hybrid structures and synchronisation methods of SD and DES models are introduced.Practical implications– The proposed hybrid framework discussed in this research will be beneficial to modellers to simulate construction projects.Originality/value– The paper introduces a theoretical framework for a hybrid continuous- discrete simulation approach which can take into account the dynamics of project environment arising from the complex inter-related structure of various continuous influencing factors as well as the construction operations. Different steps required to develop the hybrid SD–DES model and synchronisation of SD and DES simulation methods are illustrated.