bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe heatstroke complicated with Takotsubo cardiomyopathy
Authors: Tada Yuusuke , Fukushima Hidetada , Watanabe Tomoo , Ito Shingo , Norimoto Kazunobu , Ueyama Tooru , Okuchi Kazuo 
Published: August 2015

CaseA 69 year‐old female with history of schizophrenia was transported to our hospital by ambulance due to coma. On arrival, she was hypotensive and tachycardic with a Glasgow coma scale score of 3 and a rectal core temperature of 40°C. Heatstroke was strongly suspected as the cause of the coma and hypotension. Active external cooling with an electric fan and cooled IV fluid administration were started. Her electrocardiogram (EKG) showed ST elevation in V2‐6, II, III and aVF. Echocardiography revealed apical ballooning, which indicated Takotsubo cardiomyopathy. Coronary angiography indicated normal coronary arteries.OutcomeAfter admission to the intensive care unit, her cardiovascular status gradually improved and she was transferred to the psychiatric ward on day 36.ConclusionHeatstroke and Takotsubo cardiomyopathy can share the same pathophysiology. Close evaluation of hemodynamic status and myocardial damage is critical for survival.
Effect of pre‐injury anticoagulant and antiplatelet agents on blood loss in elderly patients with severe trauma
Authors: Ohmori Takao , Kitamura Taisuke , Onishi Hirokazu , Ishihara Junko , Nojima Tsuyoshi , Yamamoto Koutarou 
Published: August 2015

AimIt has been widely reported that pre‐injury use of anticoagulant and antiplatelet agents can affect traumatic brain injury and the associated risk of mortality, however, the effect of these agents on non‐head injury site‐related blood loss remains unclear. Therefore, we investigated the effects of pre‐injury anticoagulant and antiplatelet agents on the transfusion amount and the need for massive transfusion in elderly patients with severe trauma.MethodsWe retrospectively reviewed a cohort of elderly patients with severe trauma (age, ≥65 years; Injury Severity Score, ≥16) between September 2006 and March 2014. The selected patients were subsequently divided into patients who were: only taking warfarin, aspirin, or clopidogrel; taking various combinations of these agents; and a control group who were not taking any of these agents.ResultsDuring the study period, 67 patients (20%) were taking anticoagulant and antiplatelet agents and 272 patients were included in the control group. Among these patients, 10 were receiving only warfarin, 28 were receiving only aspirin, 14 were receiving only clopidogrel, and 13 were receiving various combinations of these medications. The amount of red cell concentrate and need for massive transfusions were only significantly increased in the warfarin group (P < 0.05). Furthermore, the warfarin group had a significantly higher risk of needing a massive transfusion with multivariate logistic regression analysis (odds ratio, 5.03; 95% confidence interval, 1.25–20.20; P < 0.05).ConclusionPatients who were receiving only warfarin before their injury had an increased risk of bleeding due to non‐head injuries.
Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
Authors: Ghosh Mitrajit , Balbi Matilde , Hellal Farida , Dichgans Martin , Lindauer Ute , Plesnila Nikolaus 
Published: August 2015

ObjectiveCerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the most common inherited small‐vessel disease, is associated with vascular aggregation of mutant Notch3 protein, dysfunction of cerebral vessels, and dementia. Pericytes, perivascular cells involved in microvascular function, express Notch3. Therefore, we hypothesize that these cells may play a role in the pathogenesis of CADASIL.MethodsTwo‐, 7‐, and 12‐month‐old CADASIL mutant mice (TgNotch3R169C) and wild‐type controls were examined regarding Notch3 aggregation in pericytes, the coverage of cerebral vessels by pericytes, pericyte numbers, capillary density, blood–brain barrier (BBB) integrity, astrocytic end‐feet, and the expression of astrocytic gap junction and endothelial adherens junction protein using immunostaining and Western blot analysis. In addition, we examined cerebrovascular CO2 reactivity using laser Doppler fluxmetry and in vivo microscopy.ResultsWith increasing age, mutated Notch3 aggregated around pericytes and smooth muscle cells. Notch3 aggregation caused significant reduction of pericyte number and coverage of capillaries by pericyte processes (p < 0.01). These changes were associated with detachment of astrocytic end‐feet from cerebral microvessels, leakage of plasma proteins, reduction in expression of endothelial adherens junction protein, and reduced microvascular reactivity to CO2. Smooth muscle cells were not affected by Notch3 accumulation.InterpretationOur results show that pericytes are the first cells affected by Notch3 aggregation in CADASIL mice. Pericyte pathology causes opening of the BBB and microvascular dysfunction. Therefore, protecting pericytes may represent a novel therapeutic strategy for vascular dementia. Ann Neurol 2015;78:887–900
Nanonickel‐Catalyzed Suzuki–Miyaura Cross‐Couplings in Water
Authors: Handa Sachin , Slack Eric D. , Lipshutz Bruce H. 
Published: August 2015

AbstractNickel nanoparticles, formed in situ and used in combination with micellar catalysis, catalyze Suzuki–Miyaura cross‐couplings in water under very mild reaction conditions.
Polyphosphoester‐based paclitaxel complexes
Authors: Mitova Violeta , Hristova Tatyana , Cherkezova Rumyana , Koseva Neli , Yusa Shin‐ichi , Troev Kolio 
Published: August 2015

ABSTRACTWe demonstrated a feasible approach for the preparation of a biodegradable, water soluble polyphosphoester based paclitaxel complex. Applying poly(hydroxyoxyethylene phosphate) which contains both a strong proton accepting PO group and a proton donating POH group, paclitaxel has been physically immobilized onto the polymer via H‐bonding. The water soluble complex contained 16.7 wt % paclitaxel and more than 4000 times increased drug solubility was achieved. The polymer‐drug complex formed nanosized aggregates that were characterized by dynamic light scattering. Intravenous injection of poly(hydroxyoxyethylene phosphate) in rats at a dose of 1000 mg/kg did not induce any clinical signs or body weight gain reduction. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42772.
“Corporal Punishment and the Grace of God”: The Archaeology of a Nineteenth Century Girls’ Reformatory in South Australia
Authors: de Leiuen Cherrie 
Published: August 2015

ABSTRACTThe site of St John's provides a unique insight into the internal dynamics and materiality of a nineteenth century Catholic girls’ reformatory and the silent lives of the young women, both inmates and nuns, who were confined there. The organisation and material culture of the site reflects the intersection of Australian colonial, Catholic and “middle‐class” ideologies. This institution's purpose was to reform through the imparting of a Catholic hegemony of “appropriate” female behaviour and sexuality; this hegemony was supported by enculturation, which included the altering, confining, decorating and ordering of the St John's space. The site and its assemblage, whilst small, demonstrate the framework for, and materiality of, the reformatory system that was underpinned by deep traditions of female confinement based in Catholic institutional models. Gender as a social process is key to reading and interpreting the materiality of the St John's Reformatory for girls. Gender frames, informs and contextualises the materiality of the site, its aims, its operation and thus its archaeological interpretation. Further, the ideological gender roles and regimes related through historical accounts provide the context for the embeddedness of gender in the material culture found.
The Coordinate Control Strategy of Torque Recovery for the Parallel Hybrid Electric Vehicle
Authors: Zhang Feng‐Qi , Hu Yu‐Hui , Xi Jun‐Qiang , Li Yao 
Published: August 2015

AbstractIn this paper, a coordinated torque recovery strategy is presented and a robust control technique applied to motor torque control. It is well known that the torque recovery process influences vehicle power performance and driving comfort. In the torque recovery process, it is difficult to recover to the target torque as engine torque response is limited by emissions or the control algorithm in an Engine Control Unit (ECU), which results in poor vehicle power performance. To solve this problem and taking the different torque characteristics between the engine and the motor into consideration in the dynamic coupling process, a new coordination torque recovery control strategy based on the motor torque compensation for improving the vehicle performance is proposed. The engine torque is dynamically compensated by motor torque to improve power performance. In order to achieve better performance, a new control law, which employs the integral of the tracking error and state feedback, is described for the torque control of motors. The controller was designed by a linear matrix inequality (LMI)‐based optimization to obtain an optimal gain. The simulation results illustrate the effectiveness and robustness of the controller. Finally, the torque recovery control strategy is compared to methods that do not use motor torque compensation. The comparative test results demonstrate that the proposed torque recovery control strategy improves the power of the vehicle effectively, reduces shift shock, and ensures comfort.
Betrieb des Hochstraßenabschnitts der M4 im Westen Londons
Authors: Hendy Chris R. , Brock Chris T. , Nicholls Antony D. J. , El‐Belbol Said 
Published: August 2015

AbstractBei dem Hochstraßenabschnitt der M4 in West London handelt es sich um einen Betonbrückenbau von 1,9 Kilometer Länge, der eine Hauptverkehrsachse für die Zufahrt nach London darstellt. Um die Instandsetzung der Brückenquerträger dem Grad der Schädigung nach zu priorisieren, wurde ein Maßnahmenmodell ausgearbeitet, das die Bewertung der Tragsicherheit mit der prognostizierten Zustandsverschlechterung, der Modellierung der Korrosion und der Rissbildung verknüpft. Um die öffentliche Sicherheit bei einer fortdauernden Verkehrsbelastung sicherzustellen sowie den Verstärkungsbedarf zu ermitteln, wurden weitere Bewertungen durchgeführt; darunter eine dreidimensionale Fachwerkmodellanalyse, eine nichtlineare Finite‐Elemente‐Analyse und eine plastische Analyse.Management of the M4 Elevated Section SubstructuresThe M4 Elevated Section in West London is a 1.9 km concrete viaduct structure providing a major arterial route into London. An intervention model bringing together structural assessment and forecast deterioration, corrosion modeling and cracking has been developed to prioritise structural rehabilitation of the substructure crosshead beams. To evaluate residual strength an initial assessment of crossheads was undertaken, which identified a deficiency in tensile capacity at the ends of the crosshead cantilevers compared to current demands. Further assessment has been undertaken, including three dimensional strut and tie, non‐linear finite element analysis and plastic analysis, to confirm public safety with continued trafficking of the structure, and to determine the need for strengthening.Additionally extensive monitoring of the crossheads has been implemented including mapping of all cracks, and remote crack monitoring to safeguard the substructures and allow early interventions. The long term maintenance strategy brings together strengthening and cathodic protection concrete preservation methods with removal and repair of concrete delamination.This paper discusses the development of the prioritisation process including deterioration modeling, together with the extended structural analysis to formulate a strengthening programme for these substructures.
Structural Health Monitoring (SHM) an der Scherkondetalbrücke: eine semi‐integrale Eisenbahn‐Betonbrücke
Authors: Marx Steffen , Wenner Marc 
Published: August 2015

AbstractSemi‐integrale Brücken sind durch die monolithische Verbindung zwischen dem Überbau und den Pfeilern gekennzeichnet. Dadurch beteiligt sich jedes Element des Tragwerks am Abtrag der Verkehrslasten. Gleichzeitig treten durch Temperaturänderungen, Kriechen, Schwinden oder Setzungen große Zwangskräfte auf. Diese Kräfte müssen beim Entwurf der Brücke besonders berücksichtigt werden und sollten durch eine vorteilhafte Verteilung der Steifigkeiten, insbesondere in den Unterbauten, reduziert werden. Der Bau von semi‐integralen Brücken im Rahmen von langen Viadukten ist auch im internationalen Maßstab ein Novum. Um die Risiken im Zusammenhang mit diesem Bauwerkstyp, der noch nicht endgültig normativ geregelt ist, zu reduzieren und um Erfahrungen über die Berechnungsannahmen zu gewinnen, wurde vom Eisenbahnbundesamt eine umfassende Überwachung der Brücken gefordert. In der vorliegenden Untersuchung werden einige Ergebnisse der Langzeitmessungen an der Scherkondetalbrücke vorgestellt.Structural Health Monitoring of the Scherkondetalbrücke: a semi integral concrete railway bridgeSemi integral bridges are characterized by the monolithic connection between the superstructure and the piers. Thereby every element of the structure participates to the transfer of forces due to traffic loads. Simultaneously, high constraining forces due to thermal variation, creep, shrinkage or settlements appears. These forces have to be accurately taken into account when designing the bridge and should be reduced through an advantageous distribution of the stiffness, especially in the substructure. The construction of semi integral bridges in the case of long viaducts is an innovation, also on international scale. In order to limit the risks associated with this non‐definitively regulated type of structure and in order to collect experience about the calculation assumptions, the authorities required an extensive monitoring of the bridges. In this paper, a few results of the long‐term measurements on the Scherkondetalbrücke will be presented.
Instandsetzung und Verbreiterung der “Nels River Bridge” auf der Road R37 in Südafrika
Authors: Miller Raimund G. , Nel Ryno , Kruger Edwin J. 
Published: August 2015

AbstractDer vorliegende Beitrag befasst sich mit der Instandsetzung, Verstärkung und Verbreiterung der “Nels River Bridge” in der Provinz Mpumalanga in Südafrika. Es werden die Komplexität der einzelnen Bemessungsschritte dargestellt und Lösungen und Konstruktionstechniken erörtert, die angewendet wurden, um das Projekt erfolgreich zum Abschluss zu bringen.Repair and Widening of the Nels River Bridge on Road R37 in South AfricaThis paper deals with the repair, strengthening, improvement and widening of the Nels River Bridge situated in the Mpumalanga province of South Africa. The paper outlines the design complexities and discusses the solutions and the construction techniques followed that resulted in a successful project.
Betontechnologischer Ansatz zur Erhaltung des einzigartigen denkmalgeschützten “Hermitage‐Wellenbrechers” auf Jersey
Authors: Hold Steve 
Published: August 2015

AbstractDie Kanalinsel Jersey verfügt über einen bedeutenden Handelshafen, der nicht nur lebenswichtig für die tägliche Versorgung der Insel sondern auch der Hauptanreisehafen für den wichtigen Fremdenverkehr ist. Der gesamte Hafen von Saint Helier ist durch den sog. “Hermitage‐Wellenbrecher” vor Wind und Wellen aus vorwiegend südwestlicher Richtung geschützt. Mit dem Bau des Wellenbrechers aus vorgefertigten Betonteilen wurde im Jahr 1874 begonnen. Infolge der Stürme in den Monaten Februar und März 2014 sind jedoch erhebliche Schäden am Oberflächenschutzsystem der Betonfertigteile und an den Fugen des nach Südwesten ausgerichteten Wandabschnitts sichtbar geworden. Mithilfe petrografischer Untersuchungen an Betonproben wurde eine verzögerte Ettringitbildung festgestellt. Das Betoninstandsetzungskonzept wurde darauf abgestellt und die denkmalpflegerischen Aspekte berücksichtigt. Der vorliegende Beitrag fasst die Herangehensweise zusammen.Modern Techniques and Concrete Technology used to conserve a unique Heritage BreakwaterThe channel island of Jersey has one major commercial port which is not only vital for the island's daily supplies but also the main port of entry for the important tourist trade. All of St Helier Harbour is protected from the south‐westerly prevailing wind and waves by the Hermitage Breakwater started in 1874.The damage to the surface protection of the precast blocks and joints on this south‐west facing section of the wall of the pre‐1887 construction was seen to have significantly deteriorated after the Feb/March 2014 storms.Using petrography from concrete core samples it was found that D.E.F. (Delayed Ettringite Formation) was present which meant that the blocks, once they had sustained surface damage had a residual capacity when coming in to contact with sea water as the outer concrete was worn away had the ability to ‘heal itself’.
Sr2ZnWO6:Eu3+,Bi3+,Li+: a potential white‐emitting phosphor for near‐ultraviolet white light‐emitting diodes
Authors: Ma Yuanyuan , Ran Weiguang , Li Weina , Ren Chunyan , Jiang Haiyan , Shi Jinsheng 
Published: August 2015

AbstractA series of Sr2ZnWO6 phosphors co‐doped with Eu3+, Bi3+ and Li+ were prepared using the Pechini method. The samples were tested using X‐ray diffraction and luminescence spectroscopy. The results show that the samples can be effectively excited by near‐ultraviolet (UV) and UV light. The introduction of Bi3+ and Li+ significantly enhances the fluorescence emission of Sr2ZnWO6:Eu3+ and changes the light emitted by the phosphors from bluish‐green to white. When excited at 371 nm, Sr2–x–zZn1–yWO6:xEu3+,yBi3+,zLi+ (x = 0.05, y = 0.05, z = 0.05, 0.1 and 0.15) samples emit high‐performance white light. Intense red–orange emission is also observed when excited by UV light. The obtained phosphor is a potential white‐emitting phosphor that could meet the needs of excitation sources with near‐UV chips. In addition, this phosphor might have promising application as a red–orange emitting phosphor for white light‐emitting diodes based on UV light‐emitting diodes. Copyright © 2015 John Wiley & Sons, Ltd.
The long‐lasting love affair between the budding yeast Saccharomyces cerevisiae and the Epstein‐Barr virus
Authors: Lista María José , Voisset Cécile , Contesse Marie‐Astrid , Friocourt Gaëlle , Daskalogianni Chrysoula , Bihel Frédéric , Fåhraeus Robin , Blondel Marc 
Published: August 2015

AbstractThe Epstein‐Barr gammaherpesvirus (EBV) is the first oncogenic virus discovered in human. Indeed, EBV has been known for more than 50 years to be tightly associated with certain human cancers. As such, EBV has been the subject of extensive studies aiming at deciphering various aspects of its biological cycle, ranging from the regulation of its genome replication and maintenance to the induction of its lytic cycle, including the mechanisms that allow its immune evasion or that are related to its tumorogenicity. For more than 30 years the budding yeast Saccharomyces cerevisiae has fruitfully contributed to a number of these studies. The aim of this article is to review the various aspects of EBV biology for which yeast has been instrumental, and to propose new possible applications for these yeast‐based assays, as well as the creation of further yeast models dedicated to EBV. This review article illustrates the tremendous potential of S. cerevisiae in integrated chemobiological approaches for the biomedical research.
Effect of rescue surgery after non-curative endoscopic resection of early gastric cancer
Authors: Kim E R , Lee H , Min B -H , Lee J H , Rhee P -L , Kim J J , Kim K -M , Kim S 
Published: August 2015

Abstract

Background
Whether rescue surgery confers a survival benefit in patients undergoing non-curative endoscopic resection of early gastric cancer remains controversial.

Methods
This was a retrospective review of patients who underwent non-curative endoscopic resection of at least one lesion of differentiated-type early gastric cancer between 2000 and 2011. Patients with a positive lateral resection margin as the only non-curative factor were excluded. Outcome was investigated by univariable (Kaplan–Meier) and multivariable (Cox proportional hazards) analysis.

Results
Some 341 patients underwent non-curative endoscopic resection for at least one lesion of differentiated-type early gastric cancer. Sixty-seven patients with a positive lateral resection margin as the only non-curative factor were excluded, leaving 274 patients for analysis; 194 had rescue surgery and 80 had no additional treatment. The median duration of follow-up was 60·5 months. Patients who had rescue surgery were younger, had a lower Charlson co-morbidity index score, smaller tumours and a higher lymphovascular invasion rate than patients with no treatment. Among 194 patients who had rescue surgery, intragastric local residual tumours were found in ten (5·2 per cent) and lymph node metastases in 11 (5·7 per cent). Patients with lymph node metastasis were significantly older than those without metastasis; no other significant differences were found. Univariable analysis showed that patients aged less than 65 years, those with a Charlson co-morbidity index score below 4 and patients undergoing rescue surgery had significantly longer overall survival. Five-year overall survival rates in the rescue surgery and no-treatment groups were 94·3 and 85 per cent respectively. In multivariable analysis, rescue surgery was identified as the only independent predictor of overall survival after non-curative endoscopic resection of early gastric cancer.

Conclusion
Rescue surgery confers a survival benefit after non-curative endoscopic resection of early gastric cancer.