bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autism, Neurodiversity and the Welfare State: The Challenges of Accommodating Neurological Difference
Authors: Orsini Michael 
Published: May 2013

Abstract.In the last decade, autism has become one of the most hotly contested health policy issues in North America and beyond. From debates about the role of vaccines to the efficacy of therapeutic interventions, a range of civil society actors has been advocating for policy and societal change in the field, with mixed success. In Canada, this culminated in 2004 with a much-publicized Supreme Court decision—Auton v. British Columbia—that pitted parents of autistic children against the BC government, which was unwilling to cover the costs of behavioural treatment for autistic children. In contrast to parent-led advocacy groups, there has been a flurry of civil society activity waged by autistic self-advocates who decry the focus on curing autistic people and press instead for the recognition of neurological difference. Drawing on interviews with advocates in Canada and the US, this article highlights these contending perspectives and argues that both pose fundamental challenges to how we view the redistributive aims of the welfare state in Canada and beyond.Résumé.Au cours de la dernière décennie, l'autisme est devenu l'un des enjeux les plus controversés dans le domaine de la santé au Canada et à l'étranger. Que ce soit lors de débats sur le rôle des vaccins ou encore sur l'efficacité des interventions thérapeutiques, plusieurs acteurs de la société civile ont milité, avec un succès mitigé, en faveur de changements dans politiques et sociaux par rapport à l'autisme. Au Canada, cet activisme résultera en une décision fort controversée de la Cour Suprême en 2004,Auton v. Colombie-Brittanique, portant sur un conflit entre les parents d'enfants autistes et le gouvernement de la Colombie-Britannique, qui refusait de payer le coût des traitements pour les enfants autistes. En parallèle au militantisme des parents d'enfants autistes, des individus autistes se sont aussi mobilisés pour dénoncer cette fois l'objectif même de guérir les personnes autistes. Ces derniers exigent plutôt que soient reconnues leurs différences et, de manière plus large, le principe de la diversité neurologique. Se basant sur des entrevues avec des militants et des militantes, cet article présente ces différentes perspectives et démontre qu'elles remettent en question la façon dont nous conceptualisons le modèle de redistribution associé à l'État-providence.
A high-resolution, multiproxy stratigraphic analysis of the Devonian–Carboniferous boundary sections in the Moravian Karst (Czech Republic) and a correlation with the Carnic Alps (Austria)
Authors: KUMPAN TOMÁŠ , BÁBEK ONDŘEJ , KALVODA JIŘÍ , FRÝDA JIŘÍ , MATYS GRYGAR TOMÁŠ 
Published: May 2013

AbstractA multidisciplinary correlation of the Devonian–Carboniferous (D–C) boundary sections from the Moravian Karst (Czech Republic) and the Carnic Alps (Austria), based on conodont and foraminifer biostratigraphy, microfacies analysis, field gamma-ray spectroscopy (GRS), carbon isotopes and element geochemistry, is presented in this paper. The study is focused on the interval from the MiddlePalmatolepis gracilis expansaZone (Late Famennian) to theSiphonodella sandbergiZone (Early Tournaisian). In Lesní lom (Moravian Karst), a positive δ13C excursion in theBisphatodus costatus–Protognathodus kockeliInterregnum from a distinct laminated carbonate horizon is correlated with a carbon isotope excursion from the Grüne Schneid section of the Carnic Alps and is interpreted as the equivalent of the Hangenberg black shales and a local expression of the global Hangenberg Eventsensu stricto. Higher up at both sections, a significant increase in the terrigenous input, which is inferred from the GRS signal and elevated concentrations of terrigenous elements (Si, Ti, Zr, Rb, Al, etc.), provides another correlation tieline and is interpreted as the equivalent of the Hangenberg sandstone. Both horizons are discussed in terms of relative sea-level fluctuations and palaeoceanographic changes. Recent studies show that conodont biostratigraphy is facing serious problems associated with the taxonomy of the first siphonodellids, their dependence on facies and discontinuous occurrences of protognathodids at the D–C boundary. Therefore, the correlative potential of geochemical and petrophysical signatures is high and offers an alternative for the refining of the problematic biostratigraphic division of the D–C boundary.
Two cases of nasopharyngeal branchial cleft cyst treated by powered instrument assisted marsupialisation
Authors: Kim Y W , Baek M-J , Jung K H , Park S K 
Published: May 2013

AbstractObjective:We report two extremely rare cases of symptomatic nasopharyngeal branchial cleft cyst treated by powered instrument assisted marsupialisation.Methods:Case report and literature review concerning nasopharyngeal branchial cleft cyst and surgical treatment methods.Results:The first case was a two-year-old boy with a 1 × 2 cm, cystic, oropharyngeal mass, who also had severe snoring and sleep apnoea. The second case was a 56-year-old man with right nasal obstruction and a sensation of fullness in the right ear. In both cases, we performed endoscopic marsupialisation using a powered instrument. There was no recurrence in either case over two years of follow up.Conclusion:Powered instrument marsupialisation is a simple, effective and less invasive technique for the treatment of nasopharyngeal branchial cleft cyst.
Testing the Churchill Hypothesis: Popular Support for Democracy and its Alternatives
Authors: Rose Richard , Mishler William 
Published: May 2013

ABSTRACTWhereas many studies of democratization evaluate it in idealist terms, Winston Churchill offered a relativist criterion, democracy being a lesser evil compared to other types of regime. Since everyone in a post-Communist society has lived in at least two different regimes, the New Democracies Barometer survey of post-Communist countries can ask people to evaluate five alternative regimes: a return to Communist rule, the army taking over, monarchy, rule by a strong leader, and decision making by economic experts. Factor analysis shows endorsement of three alternatives—the return to Communism, army rule, and personal dictatorship—form an authoritarianism scale. It also shows support for authoritarian rule is confined to a minority. Five hypotheses are tested to see what accounts for this. The political legacy of the past is more important than current government performance, economic attitudes, social structure differences, and national culture and traditions. Endorsement of economic technocrats making decisions is not related to authoritarianism; it reflects some national differences. Given the importance of experiencing both democraticandundemocratic regimes, the Churchill hypothesis does not apply in a country that has not yet attempted to introduce democratic institutions.
First Responders after Disasters: A Review of Stress Reactions, At-Risk, Vulnerability, and Resilience Factors
Authors: Alexander David A. , Klein Susan 
Published: May 2013

AbstractDisasters are widely reported, commonplace events that characteristically leave an enormous legacy of human suffering through death, injury, extensive infrastructural damage, and disorganization to systems and communities.The economic costs may be almost incalculable. Professional and civilian first responders play a vital role in mitigating these effects. However, to maximize their potential with the minimum health and welfare costs to first responders, is important to have a good understanding of the demands of such work on them, how they cope, and what enables them to fulfi ll their roles.This review will explore these themes by highlighting important findings and areas of uncertainty.
Toxicity Evaluation of Two Dental Composites: Three-Dimensional Confocal Laser Scanning Microscopy Time-Lapse Imaging of Cell Behavior
Authors: Attik Ghania Nina , Pradelle-Plasse Nelly , Campos Doris , Colon Pierre , Grosgogeat Brigitte 
Published: May 2013

AbstractThe purpose of this study was to investigate thein vitrobiocompatibility of two dental composites (namely A and B) with similar chemical composition used for direct restoration using three-dimensional confocal laser scanning microscopy (CLSM) time-lapse imaging. Time-lapse imaging was performed on cultured human HGF-1 fibroblast-like cells after staining using Live/Dead®. Image analysis showed a higher mortality rate in the presence of composite A than composite B. The viability rate decreased in a time-dependent manner during the 5 h of exposure. Morphological alterations were associated with toxic effects; cells were enlarged and more rounded in the presence of composite A as shown by F-actin and cell nuclei staining. Resazurin assay was used to confirm the active potential of composites in cell metabolism; results showed severe cytotoxic effects in the presence of both no light-curing composites after 24 h of direct contact. However, extracts of polymerized composites induced a moderate decrease in cell metabolism after the same incubation period. Composite B was significantly better tolerated than composite A at all investigated end points and all time points. The finding confirmed that the used CLSM method was sufficiently sensitive to differentiate the biocompatibility behavior of two composites based on similar methacrylate monomers.
Positional goods and Robert Lee Hale's legal economics
Authors: VATIERO MASSIMILIANO 
Published: May 2013

AbstractThe legal realist Robert Lee Hale offered a definition of freedom as a zero-sum game: each volitional freedom implies some degree of coercion over other people's freedom, and at the same time one's freedom is subject to some degree of control and coercion by others. The objective of our work is to develop this idea along with the theory of positional goods. This allows us to illustrate the externalities deriving from the ‘consumption’ of freedom and detail the role of the lawmaker in accordance with the Halean contribution.
Developing supervisory competence: preliminary data on the impact of CBT supervision training
Authors: Taylor Katherine Newman , Gordon Kenneth , Grist Simon , Olding Charlotte 
Published: May 2013

AbstractClinical supervision is key to the delivery and governance of effective psychological work. We place increasing emphasis on the evidence base in our clinical decision making, and yet there is no comparable body of information to inform our supervisory practice. This is a serious problem for psychological therapists; there is an urgent need for theoretically driven and empirically evaluated approaches to supervision, and the training of such skills. This preliminary evaluation examined the impact of a 5-day training designed for Improving Access to Psychological Therapies (IAPT) supervisors new to the role. A within-subject, repeated-measures design was used to compare self-assessed supervision competencies over the course of training. Twenty-eight IAPT supervisors completed 5 days’ training based on the Supervision Competencies Framework and IAPT Supervision Guidance. Significant improvements were found in ratings of generic, specific, applied and meta-supervision competencies, as well as overall competency. This evaluation gives preliminary support for the impact of training on supervisory competencies. There are clear limitations, particularly the lack of objective measures and comparison training. Nevertheless, in the context of a very limited evidence base to date, the study contributes to a more robust approach to developing supervisory competence in clinical practice.
Cyber conflict and international humanitarian law
Authors: Lin Herbert 
Published: May 2013

AbstractConflict in cyberspace refers to actions taken by parties to a conflict to gain advantage over their adversaries in cyberspace by using various technological tools and people-based techniques. In principle, advantages can be obtained by damaging, destroying, disabling, or usurping an adversary's computer systems (‘cyber attack’) or by obtaining information that the adversary would prefer to keep secret (‘cyber espionage’ or ‘cyber exploitation’). A variety of actors have access to these tools and techniques, including nation-states, individuals, organized crime groups, and terrorist groups, and there is a wide variety of motivations for conducting cyber attacks and/or cyber espionage, including financial, military, political, and personal. Conflict in cyberspace is different from conflict in physical space in many dimensions, and attributing hostile cyber operations to a responsible party can be difficult. The problems of defending against and deterring hostile cyber operations remain intellectually unresolved. The UN Charter and the Geneva Conventions are relevant to cyber operations, but the specifics of such relevance are today unclear because cyberspace is new compared to these instruments.
Multilevel functional and structural defects induced by two pathogenic mitochondrial tRNA mutations
Authors: Wang Meng , Zhou Xiao-Long , Liu Ru-Juan , Fang Zhi-Peng , Zhou Mi , Eriani Gilbert , Wang En-Duo 
Published: May 2013

Point mutations in hmtRNAs (human mitochondrial tRNAs) can cause various disorders, such as CPEO (chronic progressive external ophthalmoplegia) and MM (mitochondrial myopathy). Mitochondrial tRNALeu, especially the UUR codon isoacceptor, is recognized as a hot spot for pathogenic mtDNA point mutations. Thus far, 40 mutations have been reported in hmtRNAsLeu. In the present paper, we describe the wide range of effects of two substitutions found in the TΨC arms of two hmtRNAsLeu isoacceptors. The G52A substitution, corresponding to the pathogenic G12315A mutation in tRNALeu(CUN), and G3283A in tRNALeu(UUR) exhibited structural changes in the outer corner of the tRNA shape as shown by RNase probing. These mutations also induced reductions in aminoacylation, 3′-end processing and base modification processes. The main effects of the A57G substitution, corresponding to mutations A12320G in tRNALeu(CUN) and A3288G in tRNALeu(UUR), were observed on the aminoacylation activity and binding to hmEF-Tu (human mitochondrial elongation factor Tu). These observations suggest that the wide range of effects may amplify the deleterious impact on mitochondrial protein synthesis in vivo. The findings also emphasize that an exact understanding of tRNA dysfunction is critical for the future development of therapies for mitochondrial diseases.
Prevalence of Francisella noatunensis subsp. orientalis in Cultured Tilapia on the Island of Oahu, Hawaii
Authors: Soto Esteban , McGovern-Hopkins Kathleen , Klinger-Bowen Ruth , Fox Bradley K. , Brock James , Antonio Nathene , Waal Zelda , Rushton Stephen , Mill Aileen , Tamaru Clyde S. 
Published: May 2013

Abstract
Francisellosis is an emergent disease in cultured and wild aquatic animals. The causative agent, Francisella noatunensis subsp. orientalis (Fno), is a gram-negative bacterium recognized as one of the most virulent pathogens of warmwater fish. The main objective of this project was to investigate the prevalence of Fno in cultured tilapia (specifically, Mozambique Tilapia Oreochromis mossambicus, Koilapia [also known as Wami Tilapia] O. hornorum, Blue Tilapia O. aureus, and Nile Tilapia O. niloticus hybrids) on the island of Oahu, Hawaii, using conventional and real-time PCR assays followed by statistical modeling to compare the different diagnostic methods and identify potential risk factors. During 2010 and 2012, 827 fish were collected from different geographical locations throughout the island of Oahu. Upon collection of fish, the water temperature in the rearing system and the length of individual fish were measured. Extraction of DNA from different tissues collected aseptically during necropsy served as a template for molecular diagnosis. High correlation between both molecular methods was observed. Moreover, the bacterium was isolated from infected tilapia on selective media and confirmed to be Fno utilizing a species-specific Taqman-based real-time PCR assay. Although a direct comparison of the prevalence of Fno between the different geographical areas was not possible, the results indicate a high prevalence of Fno DNA in cultured tilapia throughout the farm sites located on Oahu. Of the different tilapia species and hybrids currently cultured in Hawaii, Mozambique Tilapia were more susceptible to infection than Koilapia. Water temperature in the rearing systems and fish size also had a strong effect on the predicted level of infection, with fish held at lower temperatures and smaller fish being more susceptible to piscine francisellosis.
Received November 30, 2012; accepted February 22, 2013
Specific and Rapid Diagnosis of Edwardsiella tarda by a Novel Loop-Mediated Isothermal Amplification Targeting the Upstream Region of hlyb Gene
Authors: Xie Guo-Si , Huang Jie , Zhang Qing-Li , Shi Cheng-Yin , Wang Xiu-Hua , Liu Qing-Hui 
Published: May 2013

Abstract
Edwardsiella tarda has become one of the most severe pathogens in aquaculture industries throughout the world; therefore, a specific and rapid identification method for this bacterium is urgently needed. In the present study, a novel loop-mediated isothermal amplification (LAMP) was developed by targeting the upstream region of the hlyb gene of E. tarda, which was then named as UH-LAMP. The Mg2+ concentrations, the reaction temperature, and the reaction time of UH-LAMP were optimized to 10 mM, 65°C, and 45 min, respectively. The detection limit of the UH-LAMP was 100-times higher than that of conventional polymerase chain reaction (10 versus 1000 CFU/test). Furthermore, the new UH-LAMP assay showed no cross-reactivity to the E. ictaluri belonging to the other species in the genus Edwardsiella. The high specificity of the assay was also confirmed by testing the nine strains of E. tarda collected from different geographical locations and the other 20 bacteria species. The assay can be performed in a simple water bath or a heat block and the detection result can be visualized by adding a fluorescent reagent to the reaction mixture. Taken together, our preliminary results indicate that this UH-LAMP assay provided a rapid, sensitive, and species-specific diagnostic tool for E. tarda and can easily be applied for the diagnosis under clinical or onsite conditions.
Received December 10, 2012; accepted February 22, 2013
Long-Term Changes in Fish Assemblage Structure in the Yellow River Estuary Ecosystem, China
Authors: Shan Xiujuan , Sun Pengfei , Jin Xianshi , Li Xiansen , Dai Fangqun 
Published: May 2013

Abstract
The Yellow River estuary ecosystem is an important spawning ground for many species found in the Bohai Sea and Yellow Sea and contributes substantially to the fishery resource structure and biological reproduction in the northern China Sea. Based on long-term ecosystem surveys in the Yellow River estuary during the main spawning period (May) of most fishery species from 1959 to 2011, the responses of the ecosystem, including regime shifts in species composition, biomass, diversity, and other related factors, were analyzed in this study. Since the 1980s, the dominant large-size species of high economic value (e.g., Largehead Hairtail Trichiurus lepturus) have been replaced by short-lived, low-trophic-level, planktivorous pelagic species (e.g., Scaly Hairfin Anchovy Setipinna taty and Japanese Anchovy Engraulis japonicus). Currently, traditional commercially targeted fishes, such as the Largehead Hairtail, Red Seabream Pagrus major, and Pacific Herring Clupea pallasii, are locally extinct. There has been a rapid shift of dominant species from highly valued, high-trophic-level, large-sized demersal species with complicated age structures to low-value, low-trophic-level, small-sized pelagic species with simple age structures; this shift has resulted in major changes to the ecological cycle and restoration of fishery resources. The fish catch declined from 421.66 kg/h in 1959 to 0.25 kg/h in 2008 and then increased to 3.62 kg/h in 2011. Diversity and evenness indices showed a continuously increasing trend during 1959–2011. The Yellow River estuary may be significantly compromised by overfishing, climate change, dam construction, and pollution, resulting in the decline of traditional fishing industries and reduced biodiversity in this ecosystem.
Received August 30, 2012; accepted January 11, 2013
First Report of Tomato spotted wilt virus on a New Host Leuzea carthamoides in Bulgaria and the World
Authors: Dikova B. , Petrov N. , Djourmanski A. , Lambev H. 
Published: May 2013

The Siberian plant Leuzea carthamoides or maral root was introduced to Europe as a medicinal crop. Tomato spotted wilt virus (TSWV), genus Tospovirus, family Bunyaviridae, caused a harmful outbreak on L. carthamoides in central Bulgaria near the town of Kazanluk in 2009. In 2011, TSWV was identified on young sprouts from the rootages of L. carthamoides in the same place near the town of Kazanluk, Bulgaria, by means of indicator (test) plants, double antibody sandwich (DAS)-ELISA, and reverse transcription (RT)-PCR. Disease symptoms were small yellow spots on the young leaves grown from the tested sprouts and distortions of the leaf lamina. The old leaves had large yellow spots and necrosis, without deformations. Most of those L. carthamoides plants with such symptoms died in the second and third year. The number of the plants in the plantations decreased 20 to 40% during the 3-year period and some of these losses were from the virus disease except the environment conditions. DAS-ELISA was carried out with polyclonal TSWV antiserum of LOEWE Biochemica, GmbH, Germany. We obtained positive extinction values ODλ 405nm 0.358 ± 0.091 compared to the negative 0.053 ± 0.016 and the positive control 0.510 at a confidential interval at P ≤ 0.05. TSWV symptoms were observed on the following indicator plants according to Antignus et al. (1) and DPV/412 (2): Chenopodium quinoa, Cucumis sativus, Datura stramonium, Nicotiana glutinosa, N. rustica, N. tabacum cv. Samsun NN, and Petunia hybrida. TSWV caused on C. quinoa and on cotyledons of C. sativus cv. Delikates local chlorotic lesions only. In this TSWV differed from CMV because CMV caused systemic mosaic symptoms. Local small necrotic lesions and no systemic symptoms were observed on P. hybrida. We noticed systemic symptoms caused from TSWV on D. stramonium, N. glutinosa, N. rustica, and N. tabacum cv. Samsun NN. The systemic symptoms were chlorotic spots, concentric ring spots, and line patterns proceeding to necrosis. RT-PCR, adapted by Mumford et al. (3), was carried out on samples of L. carthamoides. Oligonucleotide primer sequences were used in accordance with Mumford et al. (3). The DNA fragment was visualized by UV trans-illumination. A fragment of the TSWV genome with a length of 276 base pairs was found in three young L. carthamoides leaf samples taken from the sprouts (marker 100 bp). The PCR fragment was sequenced and deposited to NCBI with GenBank Accession No. KC918808. PCR master mix without RNA template was used as a negative control. L. carthamoides is a newly established TSWV host in the world. To our knowledge, this is the first report of TSWV in L. carthamoides identified by RT-PCR. References: (1) Y. Antignus et al. Phytoparasitica 25:319, 1997. (2) R. Kormelink. Descriptions of Plant Viruses, p. 412, 2005. (3) R. A. Mumford et al. J. Virol. Methods 57:109, 1996.