bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neighborhood greenspace and health in a large urban center
Authors: Kardan Omid , Gozdyra Peter , Misic Bratislav , Moola Faisal , Palmer Lyle J. , Paus Tomáš , Berman Marc G. 
Published: July 2015

AbstractStudies have shown that natural environments can enhance health and here we build upon that work by examining the associations between comprehensive greenspace metrics and health. We focused on a large urban population center (Toronto, Canada) and related the two domains by combining high-resolution satellite imagery and individual tree data from Toronto with questionnaire-based self-reports of general health perception, cardio-metabolic conditions and mental illnesses from the Ontario Health Study. Results from multiple regressions and multivariate canonical correlation analyses suggest that people who live in neighborhoods with a higher density of trees on their streets report significantly higher health perception and significantly less cardio-metabolic conditions (controlling for socio-economic and demographic factors). We find that having 10 more trees in a city block, on average, improves health perception in ways comparable to an increase in annual personal income of $10,000 and moving to a neighborhood with $10,000 higher median income or being 7 years younger. We also find that having 11 more trees in a city block, on average, decreases cardio-metabolic conditions in ways comparable to an increase in annual personal income of $20,000 and moving to a neighborhood with $20,000 higher median income or being 1.4 years younger.
Genome-scale long noncoding RNA expression pattern in squamous cell lung cancer
Authors: Wang Ying , Qian Chen-Yue , Li Xiang-Ping , Zhang Yu , He Hui , Wang Jing , Chen Juan , Cui Jia-Jia , Liu Rong , Zhou Hui , Xiao Lin , Xu Xiao-Jing , Zheng Yi , Fu Yi-Lan , Chen Zi-Yu , Chen Xiang , Zhang Wei , Ye Cheng-Cheng , Zhou Hong-Hao , Yin Ji-Ye , Liu Zhao-Qian 
Published: July 2015

AbstractIn this study, we aimed to explore the long noncoding RNA expression pattern in squamous cell lung cancer (SQCC) on a genome-wide scale. Total RNAs were extracted from 16 lung SQCC patients’ normal and matched lung cancer tissues by Trizol reagent. The expression level of genome-wide scale lncRNA and mRNA was determined by microarray. qRT-PCR was used to validate the lncRNA expression level in 47 patients. Data analyses were performed using R and Bioconductor. A total of 2,748 up and 852 down regulated probes were identified to be significantly and differentially expressed in tumor tissues. The annotation result of their co-expressed mRNAs showed that the most significantly related category of GO analysis was development and differentiation, while the most significantly related pathway was cell cycle. Subgroup analysis identified that 46 and 18 probes were specifically differentially expressed in smoking and moderately differentiated tumors, respectively. Our study indicated that clusters of lncRNAs were significantly and differentially expressed in SQCC compared with normal tissues in the same subject. They may exert a significant role in lung cancer development and could be potential targets for future treatment of SQCC.
Efficient introgression of allelic variants by embryo-mediated editing of the bovine genome
Authors: Wei Jingwei , Wagner Stefan , Lu Dan , Maclean Paul , Carlson Daniel F. , Fahrenkrug Scott C. , Laible Götz 
Published: July 2015

AbstractThe recent development of designer nucleases allows for the efficient and precise introduction of genetic change into livestock genomes. Most studies so far have focused on the introduction of random mutations in cultured cells and the use of nuclear transfer to generate animals with edited genotypes. To circumvent the intrinsic uncertainties of random mutations and the inefficiencies of nuclear transfer we directed our efforts to the introduction of specific genetic changes by homology-driven repair directly in in vitro produced embryos. Initially, we injected zinc finger nuclease (ZFN)-encoding mRNA or DNA into bovine zygotes to verify cleavage activity at their target site within the gene for beta-lactoglobulin (LGB) and detected ZFN-induced random mutations in 30% to 80% of embryos. Next, to precisely change the LGB sequence, we co-injected ZFNs or transcription activator-like effector nucleases (TALENs) with DNA oligonucleotides (ODNs). Analysis of co-injected embryos showed targeted changes in up to 33% (ZFNs) and 46% (TALENs) of blastocysts. Deep sequence analysis of selected embryos revealed contributions of the targeted LGB allele can reach 100% which implies that genome editing by zygote injections can facilitate the one-step generation of non-mosaic livestock animals with pre-designed biallelic modifications.
Giant rotating magnetocaloric effect induced by highly texturing in polycrystalline DyNiSi compound
Authors: Zhang Hu , Li YaWei , Liu Enke , Ke YaJiao , Jin JinLing , Long Yi , Shen BaoGen 
Published: July 2015

AbstractLarge rotating magnetocaloric effect (MCE) has been observed in some single crystals due to strong magnetocrystalline anisotropy. By utilizing the rotating MCE, a new type of rotary magnetic refrigerator can be constructed, which could be more simplified and efficient than the conventional one. However, compared with polycrystalline materials, the high cost and complexity of preparation for single crystals hinder the development of this novel magnetic refrigeration technology. For the first time, here we observe giant rotating MCE in textured DyNiSi polycrystalline material, which is larger than those of most rotating magnetic refrigerants reported so far. This result suggests that DyNiSi compound could be attractive candidate of magnetic refrigerants for novel rotary magnetic refrigerator. By considering the influence of demagnetization effect on MCE, the origin of large rotating MCE in textured DyNiSi is attributed to the coexistence of strong magnetocrystalline anisotropy and highly preferred orientation. Our study on textured DyNiSi not only provides a new magnetic refrigerant with large rotating MCE for low temperature magnetic refrigeration, but also opens a new way to exploit magnetic refrigeration materials with large rotating MCE, which will be highly beneficial to the development of rotating magnetic refrigeration technology.
The chemomodulatory effects of resveratrol and didox on herceptin cytotoxicity in breast cancer cell lines
Authors: Abdel-Latif Ghada A. , Al-Abd Ahmed M. , Tadros Mariane G. , Al-Abbasi Fahad A. , Khalifa Amany E. , Abdel-Naim Ashraf B. 
Published: July 2015

AbstractHerceptin is considered an essential treatment option for double negative breast cancer. Resveratrol and didox are known chemopreventive agents with potential anticancer properties. The aim of the current study is to investigate the influence of resveratrol and didox on the cytotoxicity profile of herceptin in HER-2 receptor positive and HER-2 receptor negative breast cancer cell lines (T47D and MCF-7 cell lines, respectively). The IC50’s of herceptin in T47D and MCF-7 were 0.133 ± 0.005 ng/ml and 23.3795 ± 1.99 ng/ml respectively. Equitoxic combination of herceptin with resveratrol or didox in T47D significantly reduced the IC50 to 0.052 ± 0.001 and 0.0365 ± 0.001 ng/ml, respectively and similar results were obtained in MCF-7. The gene expression of BCL-xl was markedly decreased in T47D cells following treatment with herceptin/resveratrol compared to herceptin alone. Immunocytochemical staining of HER-2 receptor in T47D cells showed a significant reduction after treatment with herceptin/resveratrol combination compared to herceptin alone. On the contrary, herceptin/didox combination had no significant effect on HER-2 receptor expression. Cell cycle analysis showed an arrest at G2/M phase for both cell lines following all treatments. In conclusion, herceptin/resveratrol and herceptin/didox combinations improved the cytotoxic profile of herceptin in both T47D and MCF-7 breast cancer cell lines.
Spectroscopic study of Gd nanostructures quantum confined in Fe corrals
Authors: Cao R. X. , Sun L. , Miao B. F. , Li Q. L. , Zheng C. , Wu D. , You B. , Zhang W. , Han P. , Bader S. D. , Zhang W. Y. , Ding H. F. 
Published: July 2015

AbstractLow dimensional nanostructures have attracted attention due to their rich physical properties and potential applications. The essential factor for their functionality is their electronic properties, which can be modified by quantum confinement. Here the electronic states of Gd atom trapped in open Fe corrals on Ag(111) were studied via scanning tunneling spectroscopy. A single spectroscopic peak above the Fermi level is observed after Gd adatoms are trapped inside Fe corrals, while two peaks appear in empty corrals. The single peak position is close to the higher energy peak of the empty corrals. These findings, attributed to quantum confinement of the corrals and Gd structures trapped inside, are supported by tight-binding calculations. This demonstrates and provides insights into atom trapping in open corrals of various diameters, giving an alternative approach to modify the properties of nano-objects.
Effects of stem cell transplantation on cognitive decline in animal models of Alzheimer’s disease: A systematic review and meta-analysis
Authors: Wang Zhe , Peng Weijun , Zhang Chunhu , Sheng Chenxia , Huang Wei , Wang Yang , Fan Rong 
Published: July 2015

AbstractAlzheimer’s disease (AD), an irreversible progressive neurodegenerative disease, causes characteristic cognitive impairment and no curative treatments are currently available. Stem cell transplantation offers a powerful tool for the treatment of AD. We conducted a systematic review and meta-analysis of data from controlled studies to study the impact of stem cell biology and experimental design on learning and memory function following stem cell transplantation in animal models of AD. A total of 58 eligible controlled studies were included by searching PubMed, EMBASE and Web of Science up to April 13, 2015. Meta-analysis showed that stem cell transplantation could promote both learning and memory recovery. Stratified meta-analysis was used to explore the influence of the potential factors on the estimated effect size and meta-regression analyses were undertaken to explore the sources of heterogeneity for learning and memory function. Publication bias was assessed using funnel plots and Egger’s test. The present review reinforces the evidence supporting stem cell transplantation in experimental AD. However, it highlights areas that require well-designed and well-reported animal studies.
The Effect of Age on Listening Effort
Authors: Degeest Sofie , Keppler Hannah , Corthals Paul 
Published: July 2015

Purpose
The objective of this study was to investigate the effect of age on listening effort.

Method
A dual-task paradigm was used to evaluate listening effort in different conditions of background noise. Sixty adults ranging in age from 20 to 77 years were included. A primary speech-recognition task and a secondary memory task were performed both separately and simultaneously. Multiple regression analyses were used to evaluate how age and hearing thresholds affect speech recognition and listening effort scores.

Results
Results of the multiple regression analyses showed that age is a significant determinant of listening effort, whereby listening effort increases with increasing age even when age-related variance in speech recognition is partialled out. On the basis of the regression equations and the median score for listening effort, it was found that listening effort started to increase in the fourth decade of life.

Conclusions
This study was a first exploration of listening effort from young to older adults and showed that, independent of hearing sensitivity, listening effort increases with age. To be more specific, there is a need to further investigate the cognitive functions important for speech communication while exploring their possible relationship with listening effort.
Entwicklung und Implementierung eines umfassenden Gesundheitsmanagements (Fit for Work and Life) für Mitarbeiter/innen eines Universitätsklinikums – ein Praxisbericht
Authors: Gutenbrunner C. , Egen C. , Kahl K. , Briest J. , Tegtbur U. , Miede J. , Born M. 
Published: July 2015

Zusammenfassung
Hintergrund: Vor dem Hintergrund steigender Arbeitsunfähigkeitstage (AU-Tage), verlängerter Lebensarbeitszeit und des prognostizierten Fachkräftemangels gewinnen Maßnahmen zur betrieblichen Gesundheitsförderung kontinuierlich an Bedeutung. Beschäftigte in einem Universitätsklinikum sind besonderen Belastungen ausgesetzt, was sich auch in überdurchschnittlich hohen AU-Tagen widerspiegelt. Aus diesem Grund wurde von der Medizinischen Hochschule Hannover (MHH) das Projekt „Fit for Work and Life“ (FWL) entwickelt und implementiert.
Ziele: Ziel von FWL ist es, im Rahmen eines multimodalen Ansatzes die Leistungsfähigkeit der Beschäftigten zu erhalten, zu verbessern oder wiederherzustellen sowie die AU-Tage signifikant zu reduzieren. Hierbei werden sowohl präventive als auch rehabilitative Maßnahmen angeboten.
Methodik: Das Projekt wurde durch fünf MHH-Abteilungen und der DRV Braunschweig-Hannover (DRV BS-H) nach zuvor festgelegten Grundsätzen gemeinsam entwickelt und eingeführt. Über die Parameter AU-Tage, Arbeitsfähigkeit (WAI), Lebensqualität (SF36, WHOQOL), Copingstrategien (FERUS) und Gratifikationskrisen (ERI) wird das Projekt begleitend wissenschaftlich evaluiert.
Ergebnisse und Schlussfolgerungen: Das in seiner Konzeption bislang einzigartige Projekt wurde organisatorisch erfolgreich in der MHH implementiert. Im ersten Projektjahr haben sich 376 Beschäftigte angemeldet, 182 haben die einzelnen Maßnahmen bereits abgeschlossen. 60,4% der Beschäftigten weisen zu Beginn mittelmäßige bis schlechte WAI-Werte auf. Auch die Durchschnittswerte der psychischen Summenskala des SF-36 (44,9) signalisieren eine hohe Arbeitsbelastung.
Psychological Well-Being von hochsensiblen Personen im Übergang zur Elternschaft – eine Querschnittstudie
Authors: Schmückle M. , Lindert J. , Schmolz G. 
Published: July 2015

Zusammenfassung
Hintergrund: Well-Being bei hochsensiblen Menschen im Übergang in die erste Elternschaft ist bisher wenig untersucht worden. Diese Studie geht der Frage nach, ob die erste Elternschaft hochsensible Personen stärker in ihrem Psychological Well-Being (PWB) beeinträchtigt, als nicht hochsensible Personen.
Methode: Diese Querschnittsstudie befragt Elternteile (n=614), hochsensible (n=440) und nichthochsensible (n=174) zu der Zeit des Übergangs in die Elternschaft mittels der Psychological Well-Being Scale. Unabhängige Variablen und Well-Being wurden deskriptiv und bivariat analysiert.
Ergebnisse: Well-Being von hochsensiblen Eltern sinkt (b=−10,129; p<0,05) in der Transition zur Elternschaft und ist insgesamt geringer als bei der Kontrollgruppe (7,3% der Hochsensiblen <50% des PWB; 0,6% der Nicht-hochsensiblen <50% des PWB).
Schlussfolgerung: Diese Studie liefert als eine der wenigen publizierten Untersuchungen Daten zu hochsensiblen Eltern. Es besteht hier ein dringender Forschungsbedarf, da bei einer Prävalenz von 10–20% Hochsensiblen in der Bevölkerung, vermutet werden kann, dass hochsensible junge Eltern in der Übergangsphase eine wichtige Zielgruppe der Gesundheitsförderung sein könnten.
Reliability Analysis of the Distal Radius and Ulna Classification for Assessing Skeletal Maturity for Patients with Adolescent Idiopathic Scoliosis
Authors: Cheung Jason Pui Yin , Samartzis Dino , Cheung Prudence Wing Hang , Cheung Kenneth M. C. , Luk Keith D. K. 
Published: July 2015

Study Design Prospective radiographic study. Objective To test the reliability of the Distal Radius and Ulna Classification (DRU). Methods This single-center study included prospectively recruited subjects with adolescent idiopathic scoliosis managed with bracing. The left-hand radiographs were measured using the DRU classification by two examiners. Intra- and interobserver reliability analysis were performed using intraclass correlation (ICC) analysis. Results From these clinics, 161 patients (124 females and 37 males) with left-hand radiographs were included in the study. The mean age was 13.3 years (standard deviation: 1.5). There was excellent intra- (ICC: 0.93 to 0.95) and interobserver (ICC: 0.97) reliability. Conclusions The DRU classification scheme has been shown to be accurate in determining the peak growth phase and growth cessation. It has now been confirmed to be a reliable tool. Future prospective studies should be performed to investigate its application in deciding when to apply bracing or operative treatment.
The Quality and Readability of Information Available on the Internet regarding Lumbar Fusion
Authors: Zhang Dafang , Schumacher Charles , Harris Mitchel B. , Bono Christopher M. 
Published: July 2015

Study Design An Internet-based evaluation of Web sites regarding lumbar fusion. Objective The Internet has become a major resource for patients; however, the quality and readability of Internet information regarding lumbar fusion is unclear. The objective of this study is to evaluate the quality and readability of Internet information regarding lumbar fusion and to determine whether these measures changed with Web site modality, complexity of the search term, or Health on the Net Code of Conduct certification. Methods Using five search engines and three different search terms of varying complexity (“low back fusion,” “lumbar fusion,” and “lumbar arthrodesis”), we identified and reviewed 153 unique Web site hits for information quality and readability. Web sites were specifically analyzed by search term and Web site modality. Information quality was evaluated on a 5-point scale. Information readability was assessed using the Flesch-Kincaid score for reading grade level. Results The average quality score was low. The average reading grade level was nearly six grade levels above that recommended by National Work Group on Literacy and Health. The quality and readability of Internet information was significantly dependent on Web site modality. The use of more complex search terms yielded information of higher reading grade level but not higher quality. Conclusions Higher-quality information about lumbar fusion conveyed using language that is more readable by the general public is needed on the Internet. It is important for health care providers to be aware of the information accessible to patients, as it likely influences their decision making regarding care.
Absorption and plasma kinetics of collagen tripeptide after peroral or intraperitoneal administration in rats
Authors: Yamamoto Shoko , Hayasaka Fumitaka , Deguchi Kisaburo , Okudera Toshimitsu , Furusawa Toshitake , Sakai Yasuo 
Published: July 2015

AbstractCollagen tripeptide (CTP) is a collagen-derived compound containing a high concentration of tripeptides with a Gly-X-Y sequence. In this study, the concentrations and metabolites of CTP were monitored in rat plasma after its administration. We performed a quantitative analysis using high-performance liquid chromatography tandem mass spectrometry according to the isotopic dilution method with stable isotopes. We confirmed that the tripeptides Gly-Pro-Hyp, Gly-Pro-Ala, and Gly-Ala-Hyp were transported into the plasma. Dipeptides, which are generated by degradation of the N- or C-terminus of the tripeptides Gly-Pro-Hyp, Gly-Pro-Ala, and Gly-Ala-Hyp, were also present in plasma. The plasma kinetics for peroral and intraperitoneal administration was similar. In addition, tripeptides and dipeptides were detected in no-administration rat blood. The pharmacokinetics were monitored in rats perorally administered with Gly-[3H]Pro-Hyp. Furthermore, CTP was incorporated into tissues including skin, bone, and joint tissue. Thus, administering collagen as tripeptides enables efficient absorption of tripeptides and dipeptides.
Prognostic Utility of Right Atrial Emptying Fractions in Pulmonary Arterial Hypertension
Authors: Brunner Nathan W. , Haddad Francois , Kobayashi Yukari , Hsi Andrew , Swiston John R. , Gin Kenneth G. , Zamanian Roham T. 
Published: July 2015

Although left atrial function has been extensively studied in patients with heart failure, the determinants and clinical correlates of impaired right atrial (RA) function have been poorly studied. We investigated measures of RA function in pulmonary arterial hypertension (PAH). We identified all treatment‐naive patients with World Health Organization category 1 PAH seen at our center during 2000–2011 who had right heart catheterization and 6‐minute walk test (6MWT) within 1 month of initial echocardiographic examination. Atrial size was measured using the monoplane area‐length method, and atrial function was quantified using total, passive, and active RA emptying fractions (RAEFs). We compared measures of RAEF with known prognostic clinical, echocardiographic, and hemodynamic parameters. For the subset of patients with follow‐up echocardiographic examination/6MWT within 6–18 months, we investigated the change in RAEF. In an exploratory analysis, we investigated the association between RAEF and mortality. Our population consisted of 39 patients with treatment‐naive (incident) PAH, 30 of whom had follow‐up testing. The mean total, passive, and active RAEFs were 24.4% ± 15.1%, 8.5% ± 6.9%, and 17.6% ± 13.9%, respectively. Total and active RAEFs correlated with tricuspid annular plane systolic excursion (P = 0.004 and P = 0.005) and cardiac output (P = 0.02 and P = 0.01). The change in active RAEF correlated with change in 6‐minute walk distance (P = 0.02). In our Cox regression analysis, low active and total RAEF were associated with mortality, with hazard ratios of 5.6 (95% confidence interval [CI], 1.2–26.2; P = 0.03) and 4.2 (95% CI, 1.1–15.5; P = 0.03), respectively. Passive RAEF was poorly reproducible and not associated with outcome. Measures of RAEF appear to have prognostic importance in PAH and warrant further study.
Particles and Scalar Waves in Noncommutative Charged Black Hole Spacetime
Authors: Bhar Piyali , Rahaman Farook , Biswas Ritabrata , Mondal U.F. 
Published: July 2015

Abstract
In this paper we have discussed geodesics and the motion of test particle in the gravitational field of non-commutative charged black hole spacetime. The motion of massive and massless particle have been discussed seperately. A comparative study of noncommutative charged black hole and usual Reissner–Nordström black hole has been done. The study of effective potential has also been included. Finally, we have examined the scattering of scalar waves in noncommutative charged black hole spacetime.
Direct Detection of Dark Matter with Resonant Annihilation*
Authors: Li Bo , Zhou Yu-Feng 
Published: July 2015

Abstract
In the scenario where the dark matter (DM) particles

χ

χ
¯

pair annihilate through a resonance particle R, the constraint from DM relic density makes the corresponding cross section for DM-nuclei elastic scattering extremely small, and can be below the neutrino background induced by the coherent neutrino-nuclei scattering, which makes the DM particle beyond the reach of the conventional DM direct detection experiments. We present an improved analytical calculation of the DM relic density in the case of resonant DM annihilation for s- and p-wave cases and invesitgate the condition for the DM-nuclei scattering cross section to be above the neutrino background. We show that in Higgs-portal type models, for DM particles with s-wave annihilation, the spin-independent DM-nucleus scattering cross section is proportional to ΓR/mR, the ratio of the decay width and the mass of R. For a typical DM particle mass ∼ 50 GeV, the condition leads to

Γ
R

/

m
R

>
~

ο

(

10

-
4

)

. In p-wave annihilation case, the spin-independent scattering cross section is insensitive to ΓR/mR, and is always above the neutrino background, as long as the DM particle is lighter than the top quark. The real singlet DM model is discussed as a concrete example.