bluuebunny/crossref_metadata_2025_split huggingface dataset:
HIF isoforms in the skin differentially regulate systemic arterial pressure
Authors: Cowburn Andrew S. , Takeda Norihiko , Boutin Adam T. , Kim Jung-Whan , Sterling Jane C. , Nakasaki Manando , Southwood Mark , Goldrath Ananda W. , Jamora Colin , Nizet Victor , Chilvers Edwin R. , Johnson Randall S. 
Published: October 2013

SignificanceThe differential expression of the hypoxia-inducible factor-alpha (HIF-α) isoforms in the skin of mice influences vascular resistance and is correlated with homeostatic regulation of nitric oxide synthesis. A correlation between HIF isoform expression and hypertension was found in skin biopsies from human subjects, and may indicate a mechanism in the etiology of idiopathic hypertension.
High diversity of West African bat malaria parasites and a tight link with rodentPlasmodiumtaxa
Authors: Schaer Juliane , Perkins Susan L. , Decher Jan , Leendertz Fabian H. , Fahr Jakob , Weber Natalie , Matuschewski Kai 
Published: October 2013

SignificanceUnderstanding the evolution of malaria parasites and their phylogenetic context is key to understanding this important human disease. We report an unexpected high diversity of malaria parasite genera in bats from West African forest ecosystems. Two lineages are closely related toPlasmodiumparasites from rodents, which are common laboratory model systems, and the results are consistent with switches between these hosts over their evolutionary history. Bats are considered important reservoir hosts for many pathogens, particularly viruses, and have unusually high immunological tolerances. The abundant malaria parasite infections are consistent with this exceptional immunology and suggest that in bats the parasites repeatedly evolved life cycles away from disease-causing replication in red blood cells to less pathogenic propagation in liver tissue.
Pooled RNAi screen identifies ubiquitin ligase Itch as crucial for influenza A virus release from the endosome during virus entry
Authors: Su Wen-Chi , Chen Yung-Chia , Tseng Chung-Hsin , Hsu Paul Wei-Che , Tung Kuo-Feng , Jeng King-Song , Lai Michael M. C. 
Published: October 2013

Significance
Seasonal epidemics and recurring pandemics of influenza viruses threaten public health and the global economy severely. Host factors that are essential for viral growth provide potential drug targets and are crucial for understanding the mechanism of viral infection. This paper presents a unique genetic screening approach to identify such host factors. A cellular enzyme termed Itch ubiquitin ligase was identified and found to be essential for influenza viral entry into cells. It allows the viral genome to escape from the trapping of the cells to initiate infection. This host factor fills the critical gap in our understanding of the beginning event of influenza viral infection.
Design principles governing the motility of myosin V
Authors: Hinczewski Michael , Tehver Riina , Thirumalai D. 
Published: October 2013

Significance
Myosin V, a two-headed motor protein, ferries cellular cargo by walking hand-over-hand on actin filaments. Interplay between ATP-driven conformational changes in the heads and stress due to load produces a variety of stepping dynamics: The motor can step forward or backward, or “stomp,” where one head detaches and rebinds to the same site. We created an analytically solvable theory capturing all these behaviors, quantitatively matching a wide array of single-molecule experiments. We describe the structural and chemical design principles underlying the motor’s robust function, providing a guide for how bioengineering might alter its dynamics.
Mining the O-mannose glycoproteome reveals cadherins as major O-mannosylated glycoproteins
Authors: Vester-Christensen Malene B. , Halim Adnan , Joshi Hiren Jitendra , Steentoft Catharina , Bennett Eric P. , Levery Steven B. , Vakhrushev Sergey Y. , Clausen Henrik 
Published: October 2013

Significance
Protein O-mannosylation is believed to be an abundant modification of proteins, but only very few glycoproteins with O-mannose have been identified to date. Here, we present a unique strategy for proteome-wide discovery of O-mannosylated glycoproteins, and using this strategy we find that the important cadherin and plexin families of cell membrane receptors are O-mannosylated. The presented strategy invites the opportunity for wider exploration of the O-mannose glycoproteome and studies of the functions of O-mannose glycans.
Oral delivery system prolongs blood circulation of docetaxel nanocapsules via lymphatic absorption
Authors: Attili-Qadri Suha , Karra Nour , Nemirovski Alina , Schwob Ouri , Talmon Yeshayahu , Nassar Taher , Benita Simon 
Published: October 2013

Significance
Oral drug delivery is the most convenient administration route for patients. Docetaxel, a potent anticancer drug, elicits severe side effects following intravenous administration. Furthermore, oral docetaxel absorption is prevented by biochemical barriers in the intestine. An oral formulation of docetaxel nanocapsules (NCs) embedded in microparticles was developed and elicited higher plasma docetaxel concentrations than intravenous administration of the commercial product. These unexpected results were explained by the penetration of the docetaxel NCs within the enterocytes, circumventing the barriers, where their coating was reinforced prior reaching, intact, the circulation via the lymphatic system. The oral formulation significantly improves docetaxel anticancer efficacy. This delivery concept has potential for clinical translation, allowing docetaxel chemotherapy to be switched from intravenous to oral delivery.
Tooth wear and dentoalveolar remodeling are key factors of morphological variation in the Dmanisi mandibles
Authors: Margvelashvili Ann , Zollikofer Christoph P. E. , Lordkipanidze David , Peltomäki Timo , Ponce de León Marcia S. 
Published: October 2013

SignificanceThe mandibles of the early Pleistocene hominins from Dmanisi, Georgia, exhibit wide morphological variation, but the causes of diversity remain largely unknown. Here we quantify the effects of heavy tooth wear and wear-related bone remodeling on mandibular variation. Using modern hunter–gatherer populations as a reference, we show that features such as dental arcade form, mandibular corpus height, and symphyseal inclination change substantially with progressive tooth wear. These data indicate that the Dmanisi mandibles reflect normal within-population variation augmented by interindividual differences in wear-related bone remodeling. Dmanisi further provides the first clear evidence for toothpick-induced local periodontitis. This study illustrates how excessive tooth wear leads to dentognathic pathology and complete tooth loss, which was evidently compensated for by culturally mediated food processing.
miRNA and mRNA cancer signatures determined by analysis of expression levels in large cohorts of patients
Authors: Zadran Sohila , Remacle F. , Levine R. D. 
Published: October 2013

Significance
The study of mRNA and microRNA (miRNA) expression profiles of cells and tissue has become a major tool for therapeutic development. The results of such experiments are expected to change the methods used in the diagnosis and prognosis of disease. We introduce surprisal analysis, an information-theoretic approach grounded in thermodynamics, to compactly transform the information acquired from microarray studies into applicable knowledge about the cancer phenotypic state. The analysis of mRNA and miRNA expression data from ovarian serous carcinoma, prostate adenocarcinoma, breast invasive carcinoma, and lung adenocarcinoma cancer patients and organ-specific control patients identifies cancer-specific signatures. We experimentally examine these signatures and their respective networks as possible therapeutic targets for cancer in single-cell experiments.
Self-Regulation of the Okanagan Lake Kokanee Recreational Fishery: Dynamic Angler Effort Response to Varying Fish Abundance and Productivity
Authors: Askey P. J. , Johnston N. T. 
Published: October 2013

Abstract
The fishery for kokanee Oncorhynchus nerka in Okanagan Lake, British Columbia, exemplifies three common issues in the management of recreational fisheries: time-varying stock–recruit parameters, mixed stocks within a single fishing area, and open-access fishing effort. The aggregate kokanee stock (consisting of stream-spawning and shore-spawning stocks) declined 50-fold between 1971 and 1998 and then partially recovered in the most recent decade. This contrast in fish abundance provides an opportunity to gain insights into the predator–prey dynamics of anglers and fish in an open-access sport fishery. Structural variations in the Ricker stock–recruit function were fitted to the time series of spawner escapements and fishery data to estimate the relative role of nonstationary stock–recruit parameters versus angler harvest in the observed time series. The optimal model structures selected by Akaike's information criterion suggested that kokanee dynamics were driven by external factors (e.g., lake nutrient concentration or opossum shrimp Mysis diluviana abundance) as opposed to fishery harvest. The functional response of angler catch rates to fish abundance was well predicted by a type I function (i.e., no density dependence in catchability). Conversely, the angler effort numerical response to variation in kokanee density was sigmoid, with a steep transition at an average catch rate between 1 and 2 fish/d. The interaction of angler response functions with fish recruitment dynamics led to an open-access recreational fishery that never harvested the lower-productivity (stream-spawning) stock to a level below the optimal escapement abundance, despite dramatic declines in stock productivity (i.e., recruits per spawner at low abundance) over time. Standard management reactions to declining fish abundance (successive reductions in daily bag limits) were largely ineffective in altering harvest rate or effort dynamics. Our results show that the Okanagan Lake kokanee fishery was self-regulating over a large range in fish densities and that the declines in kokanee abundance resulted from time-varying stock productivity rather than from overharvest.
Received January 15, 2013; accepted June 17, 2013
Detecting Noncompliance in the Summer Flounder Recreational Fishery Using a Mark–Recapture Growth Model
Authors: Henderson Mark J. , Fabrizio Mary C. 
Published: October 2013

Abstract
We used a mark–recapture growth model to investigate recreational angler compliance with minimum length regulations in a popular Chesapeake Bay fishery. Angler noncompliance can severely degrade the ability of fishery managers to avoid overexploitation and to achieve objectives of rebuilding plans. To discern noncompliance in the recreational fishery for Summer Flounder Paralichthys dentatus, we fitted a growth model to 3,474 recapture records from a tagging study conducted by volunteer anglers in Virginia from 2000 to 2011. Most of the tagged fish were small (i.e., sublegal size), and the average time at liberty was 86 d. Based on the growth model, Summer Flounder growth patterns changed at 34.7 cm, possibly representing the length at which the majority of fish reach maturity. The mean size of harvested fish increased in response to increases in the minimum size limit, although harvest of sublegal fish continued. Throughout the 12 years of the study, 33–79% of the tagged fish that were recaptured and harvested were predicted to be sublegal based on the growth model. The percentage of sublegal fish that were harvested increased dramatically when large (≥5 cm) increases in minimum size limits were implemented. We conclude that Virginia recreational anglers responded to management regulations by adjusting the minimum size of harvested fish but that some anglers continued to harvest sublegal fish.
Received April 9, 2013; accepted June 18, 2013
Effects of Catfish Angler Catch-Related Attitudes on Fishing Trip Preferences
Authors: Hutt Clifford P. , Hunt Kevin M. , Schlechte J. Warren , Buckmeier David L. 
Published: October 2013

Abstract
To assist the Texas Parks and Wildlife Department in developing a statewide catfish management plan, we surveyed 1,078 freshwater catfish anglers to examine their catch-related attitudes and trip preferences by using a stated choice experiment. Respondents were presented with a series of paired hypothetical fishing trip scenarios for catfish and were asked to choose the trips that they most preferred. Trip scenarios varied by the relative number of catfish that were caught and harvested, relative size of catfish that were caught, water body type, level of site development, and distance traveled (i.e., representing travel costs). A conditional logit model was fitted to analyze angler preferences by determining the influence of trip attributes on angler choice. Model results indicated that anglers’ choice of fishing trips was most influenced by distance traveled, followed by the catch-related aspects of the trip, with catfish size having a greater influence than the numbers of catfish caught or harvested. We then conducted a latent class analysis of catfish anglers, which involved the use of cluster analysis to assign anglers to five groups based on their catch-related attitude scores, and we reran the stated choice model for each cluster. Clusters ranged from harvest-oriented anglers to size-oriented anglers that were focused on catching large trophy fish. Results from these models can assist fisheries managers in setting management goals and objectives that best meet the needs of their clientele.
Received December 17, 2012; accepted June 27, 2013
Nutritional situation for larval Atlantic herring (Clupea harengus L.) in two nursery areas in the western Baltic Sea
Authors: Paulsen Matthias , Hammer Cornelius , Malzahn Arne M. , Polte Patrick , von Dorrien Christian , Clemmesen Catriona 
Published: October 2013

Abstract
The Greifswalder Bodden (GWB) is considered to be the most important spawning and nursery area for the western Baltic spring-spawning herring. However, the biotic and abiotic reasons for this are still unclear. Consequently, we investigated larval growth conditions in the GWB and in the Kiel Canal (KC), another nursery and spawning area of Baltic herring. We investigated prey quantity and quality [copepod abundance and essential fatty acid (EFA) concentration] as well as biochemically derived growth rates and fatty acid content of larval herring in spring 2011. A significant correlation between larval growth and larval EFA concentration could be observed in the GWB. The highest growth rates and EFA concentrations in the larval herring coincided with high food quality. Compensating effects of food quality on food quantity and vice versa could be observed in both the GWB and the KC. While larval growth rates in the KC were high early in the season, highest growth rates in the GWB were achieved late in the season. In conclusion, neither area was superior to the other, indicating similar growth conditions for larval herring within the region.
The accounting profession's influence on academe: South African evidence
Authors: Retief Venter Elmar , de Villiers Charl 
Published: October 2013

Purpose
– This paper aims to examine the influence of academics who are members of the profession on academic institutions.

Design/methodology/approach
– An analytic autoethnography of the influence of accounting academics who are members of the profession on South African universities, supported by publicly available information, such as policy and other documents, web sites, and published material; documentation the authors are able to gather as participants; and formal and informal interviews the authors conduct with academic managers.

Findings
– The paper finds that profession-identifying academics create and maintain rules and structures within academe, rules and structures that suit the profession. Managers who are members of the profession identify more closely with the profession than with their university. The analysis reveals the mechanics of this influence, as well as the consequences.

Originality/value
– The paper contributes to theory by synthesizing the creation of profession-inspired institutions framework and the maintenance of an institutions framework into a single framework. It also applies the theory by providing an example of a profession creating and maintaining institutionalization in an adjacent institution. The findings have implications for academia in cases where academic staff members are members of professional bodies, such as engineering and law faculties. The insights highlighted here may also be of interest to Australasian, UK and US accounting academics, because the literature contains evidence of pressures from professional bodies there.
Implementation of benchmarking concepts in Indian automobile industry – an empirical study
Authors: Panwar Avinash , Nepal Bimal , Jain Rakesh , Prakash Yadav Om 
Published: October 2013

Purpose
– This paper aims to present existence comprehensive analysis of state of implementation of benchmarking concepts in Indian automotive companies.

Design/methodology/approach
– The research is carried out through a mixed method of research approach comprising of a survey of 300 auto companies in India. Out of 300, 48 valid responses together with three additional case studies were used in the data analysis. Inclusion of case studies was aspired to get deeper insight into the issues pertaining to adoption of best practices, and subsequently the implementation of benchmarking activities.

Findings
– Benchmarking has been unanimously accepted as an effective performance and productivity improvement tool by Indian auto companies. However, Indian automobile manufacturers still see benchmarking as a tool to compare product attributes, quality attributes, operations, and processes. Moreover, it has been perceived as being less applicable at strategic level. Results also show that benchmarking is in its primary stage in the Indian automotive industry, and it still needs much more commitment from top management for its proliferation. Lesser significance is given to competitor benchmarking due to the fear of losing competitive advantage, and the problem of confidentiality. Reasons identified in this study for not using benchmarking include “lack of human resources” as most important, followed by “financial constraints”, and “lack of internal expertise”.

Research limitations/implications
– Research results should be generalized and reproduced with a larger sample size. Owing to the scarce application of benchmarking in small and medium enterprises (SMEs), separate study should be carried out to find ways to encourage benchmarking implementation in Indian auto component manufacturing SMEs.

Originality/value
– The paper provides insight into the extent of implementation of benchmarking concepts in Indian automobile industry. This study is the first attempt to understand propagation of benchmarking concepts, exclusively among Indian auto companies.
Benchmarking the interactions among barriers in third-party logistics implementation
Authors: Diabat Ali , Khreishah Abdallah , Kannan Govindan , Panikar Vinay , Gunasekaran Angappa 
Published: October 2013

Purpose
– The purpose of this paper is to analyze the interaction among some of the major barriers that may hinder the implementation of third-party logistics (TPL) in manufacturing industries.

Design/methodology/approach
– This paper uses an interpretive structural modeling (ISM) methodology to analyze the interactions among the barriers.

Findings
– It is beneficial for the management of any firm to be aware of significant barriers and to diagnose those that could be integral to the organization's future survival. Many works have focused on identifying barriers for TPL implementation, but a model for such barriers is lacking. This paper attempts to develop a model for the barriers using an ISM methodology and analyzes the mutual interactions among the barriers. The model differentiates between the barriers so that driving barriers, which can intensify other barriers, and dependent barriers are identified separately.

Originality/value
– In this research, eight barriers are considered. Interactions between the barriers are evaluated with the help of the ISM matrix. Of the eight barriers, three barriers, including the lack of application and knowledge of advanced information technology, congested roadways and ports, and fear of employees of the firm, demonstrate both strong driving power and strong dependence power, as illustrated in the MICMAC analysis.
Evaluating medical tourism enablers with interpretive structural modeling
Authors: Ranjan Debata Bikash , Sree Kumar , Patnaik Bhaswati , Sankar Mahapatra Siba 
Published: October 2013

Purpose
– The purpose of this paper is to develop a comprehensive framework to identify and classify key medical tourism enablers (MTEs) and to study the direct and indirect effects of each enabler on the growth of medical tourism in India.

Design/methodology/approach
– In this paper, an integrated approach using interpretive structural modeling (ISM) and Fuzzy Matrice d'Impacts Croisés Multiplication Appliquée á un Classement (FMICMAC) analysis has been developed to identify and classify the key MTEs, typically identified by a comprehensive review of literature and expert opinion. The key enablers are also modeled to find their role and mutual influence.

Findings
– The key finding of this modeling helps to identify and classify the enablers which may be useful for medical tourism decision makers to employ this model for formulating strategies in order to overcome challenges and to become a preferred medical tourism destination. Integrated model reveals enablers such as medicine insurance coverage, international healthcare collaboration, and efficient information system as dependent enablers. No enabler is found to be autonomous enablers. The important enablers like healthcare infrastructure facilities and global competition are found as the linkage enablers. Research in medicine and pharmaceutical science, medical tourism market, transplantation law, top management commitment, national healthcare policy, competent medical and para-medical staffs are found as the independent enablers. Integrated model also establishes the direct and indirect relationship among various enablers.

Originality/value
– The research provides an integrated model using ISM and FMICMAC to identify and classify various key enablers of medical tourism in India. In conventional cross-impact matrix multiplication applied to classification analysis, binary relationship of various enablers is considered. FMICMAC analysis helps to establish possibility of relationship among various enablers so that low-key hidden factors can be identified. The low-key hidden factors may initially exhibit marginal influence but they may show significant influence later on during analysis. The uncertainty and fuzziness of relationship among various enablers can be conveniently handled by FMICMAC and expert opinions can easily be captured. This research will help medical tourism decision makers to select right enablers for the growth of medical tourism in India.