bluuebunny/crossref_metadata_2025_split huggingface dataset:
SGLT2i effect on atrial fibrillation: A network meta‐analysis of randomized controlled trials
Authors: Mariani Marco Valerio , Manzi Giovanna , Pierucci Nicola , Laviola Domenico , Piro Agostino , D'Amato Andrea , Filomena Domenico , Matteucci Andrea , Severino Paolo , Miraldi Fabio , Vizza Carmine Dario , Lavalle Carlo 
Published: June 2024

AbstractIntroductionGliflozins are recommended as first‐line treatment in patients with heart failure and/or cardiovascular comorbidities and are demonstrated to reduce atrial fibrillation (AF) occurrence. However, it is not well known which gliflozin yields the larger cardioprotection in terms of AF occurrence reduction. Hence, we aimed to compare data regarding AF recurrence associated with different gliflozins.MethodsAn accurate search of online scientific libraries (from inception to June 1, 2023) was performed. Fifty‐nine studies were included in the meta‐analysis involving 108 026 patients, of whom 60 097 received gliflozins and 47 929 received placebo.ResultsGliflozins provided a statistically significant reduction of AF occurrence relative to standard of care therapy in the overall population (relative risks [RR]: 0.8880, 95% CI: [0.8059; 0.9784], p = .0164) and in patients with diabetes and cardiorenal diseases (RR: 0.8352, 95% CI: [0.7219; 0.9663], p = .0155). Dapagliflozin significantly decreased AF occurrence as compared to placebo (0.7259 [0.6337; 0.8316], p < .0001) in the overall population, in patients with diabetes (RR: 0.2482, 95% CI: [0.0682; 0.9033], p = .0345), with diabetes associated with cardiorenal diseases (RR: 0.7192, 95% CI: [0.5679; 0.9110], p = .0063) and in the subanalysis including studies with follow‐up ≥1 year (RR: 0.7792, 95% CI: [0.6508; 0.9330], p = .0066). No significant differences in terms of AF protection were found among different gliflozins.ConclusionsDapagliflozin use was associated with significant reduction in AF risk as compared to placebo in overall population and patients with diabetes, whereas the use of other gliflozins did not significantly reduce AF occurrence.
Evaluation of adrenal vein anatomy by adrenal venous sampling in patients with primary aldosteronism in Chinese
Authors: Yu Yang , Yang Minghui , Gong Minghui , Zhang Ying , Jiang Yinong , Song Wei 
Published: June 2024

AbstractAccurate cannulation of the adrenal vein is challenging during adrenal venous sampling (AVS) because of the variations in adrenal vein anatomy. This study aimed to investigate the adrenal venous morphology in Chinese and improve the success rate of AVS. A total of 221 participants with primary aldosteronism (PA) who underwent AVS were enrolled. Compare the morphology among subgroups divided according to sex, body mass index (BMI), and with or without adenoma. The success rate of right, left, and bilateral AVS was 98.60%, 97.20%, and 96.85%, respectively. The triangular pattern was the most common (39.37%) on the right side, while the glandlike pattern (70.14%) on the left. The proportion of adrenal venous morphology varies among patients with different sexes (χ2 = 21.335, P < .001), BMI (χ2 = 10.642 P = .031), and with or without adenoma (χ2 = 10.637, P = .031) on the right side, and the male, obese and adenoma group showed a higher proportion of glandlike pattern than triangular pattern. If only dependent on computed tomography, 9.05% of patients incorrectly diagnose the dominant side, 14.48% of patients would have inappropriate surgery meanwhile 25.34% of patients would miss the surgical opportunity. In conclusion, the most common types of right and left adrenal venous morphology were triangular pattern and glandlike pattern, respectively. Sex, BMI, and the presence of adenoma affected right adrenal venous morphology. Adequate knowledge of the adrenal venous morphology is critical for improving the success rate of AVS and making an appropriate treatment for PA.
Feeling anxious and being engaged in a warming world: climate anxiety and adolescents' pro‐environmental behavior
Authors: Becht Andrik , Spitzer Jenna , Grapsas Stathis , van de Wetering Judith , Poorthuis Astrid , Smeekes Anouk , Thomaes Sander 
Published: June 2024

BackgroundClimate anxiety is increasingly prevalent among adolescents worldwide. Are climate‐anxious adolescents prone to engage in pro‐environmental behavior? Or might the association between climate anxiety and pro‐environmental be curvilinear, such that high levels of climate anxiety become ‘paralyzing’? And do these associations depend on whether adolescents believe that, with effort, the worst impacts of climate change can still be prevented?MethodsWe addressed these questions in three studies (two preregistered; combined N = 2,211), conducted across two countries. We used cross‐sectional and longitudinal methods, and various measures of climate anxiety and pro‐environmental behavior. We performed Bayesian regression analyses comparing two models that tested competing hypotheses. The first model included a linear effect of climate anxiety on pro‐environmental behavior, and the second model included both a linear and a curvilinear (i.e. inverted U‐shaped) effect of climate anxiety on pro‐environmental behavior. Next, we added environmental efficacy to the best fitting model and explored its moderating effects.ResultsAdolescents reported low‐to‐moderate levels of climate anxiety. Across the board, we found evidence for a small, positive, and mostly linear (rather than curvilinear) association between climate anxiety and pro‐environmental behavior. While Study 1 supported a curvilinear association (Bayes Factor (BF) = 18.87), Studies 2 and 3 mostly supported a linear model (BFs range 6.86–12.71), except for weak support (BF = 1.62) for a curvilinear association between climate anxiety symptoms and public sphere pro‐environmental behavior. Adolescents' environmental efficacy moderated this link for public sphere (e.g. activism), but not private sphere (e.g. recycling), pro‐environmental behavior.ConclusionsClimate‐anxious adolescents are prone to engage in pro‐environmental behavior. We found limited evidence for ‘eco‐paralysis’ (i.e. a passive state of pro‐environmental behavioral stasis) at high levels of climate anxiety. Our results are consistent with the possibility that supporting adolescents' environmental efficacy will help climate‐anxious adolescents engage in public sphere pro‐environmental behavior.
Effect of preparation design and scan pattern on the accuracy of intraoral scans for complete arch laminate veneers under simulated intraoral variables
Authors: Şen Nazmiye , Eroglu Hatice 
Published: June 2024

AbstractPurposeThe purpose of the study was to investigate the influence of different preparation designs and scan patterns on the accuracy of intraoral scans for complete‐arch maxillary laminate veneers.Materials and MethodsThree maxillary typodonts were used to obtain reference models with three different laminate veneer preparation designs: windows (W), beveled (B), and incisal overlap (IO). Reference scans were obtained with a desktop scanner. A total of 90 complete arch intraoral scans were made with an intraoral scanner (Medit i700) following three different scan patterns: straight motion (SM), zigzag motion (ZM), and combined motion (CM). Ten scans were made in each subgroup and exported as standard tessellation language (STL) files. Assessment of accuracy was conducted with a 3D software analysis program (Geomagic Control X). Each STL file was individually aligned with the reference scan using the best fit algorithm tool, and 3D differences were calculated using the root mean square (RMS) value. Two‐way analysis of variance (ANOVA) followed by post hoc comparison tests were applied to analyze precision and trueness data (α = 0.05).ResultsTwo‐way ANOVA and post hoc comparison tests revealed significant differences among different preparation designs and scan patterns (p < 0.05). Regarding trueness, the IO when scanned with SM presented higher mean RMS than the other preparation designs (W and B) scanned with the same scanning pattern (p < 0.05). Regarding precision, the groups of W and IO presented significantly higher mean RMS than the group of B when scanned with ZM (p < 0.05).ConclusionsAccuracy of intraoral scans for complete‐arch laminate veneers was affected by different laminate veneer preparation designs and scan patterns.Clinical SignificanceModifying scan pattern according to preparation design helps to improve scan accuracy for complete‐arch laminate veneers.
Role of neoadjuvant peptide receptor radionuclide therapy in unresectable and metastatic gastro‐entero‐pancreatic neuroendocrine neoplasms: A scoping review
Authors: Kashyap Raghava , Raja Senthil , Adusumilli Ajay , Gopireddy Murali Mohan Reddy , Loveday Benjamin P. T. , Alipour Ramin , Kong Grace 
Published: June 2024

AbstractPeptide receptor radionuclide therapy (PRRT) is an established therapy for metastatic neuroendocrine neoplasms (NEN). The role of PRRT as a neoadjuvant treatment prior to surgery or other local therapies is uncertain. This scoping review aimed to define the landscape of evidence available detailing the utility of PRRT in the neo‐adjuvant setting, including the clinical contexts, efficacy, and levels of evidence. A comprehensive literature search of PUBMED, SCOPUS, and EMBASE through to December 2022 was performed to identify reports of PRRT use as neoadjuvant therapy prior to local therapies. Observational studies and clinical trials were included. A total of 369 records were identified by the initial search, and 17 were included in the final analysis, comprising 179 patients treated with neoadjuvant PRRT. Publications included case reports, retrospective cohort series and a phase 2 trial. Definitions of unresectable disease were variable. Radioisotopes used included 177Lu (n = 142) and 90Y (n = 36), used separately (n = 178) or in combination (n = 1). A combination of PRRT with chemotherapy was also explored (n = 2). Toxicity data was reported in 11/17 studies. Survival analysis was reported in 3/17 studies. Surgical resection following PRRT was reported for both the primary tumor (n = 71) and metastases (n = 12). Resection rates could not be calculated as not all publications reported whether resection was completed. Published literature exploring the use of PRRT in the neoadjuvant setting is mostly limited to case reports and retrospective cohort studies. From these limited data there is reported to be a role of PRRT in neoadjuvant setting in the literature. However, the low quality of evidence precludes any definite conclusion on the grade of disease, site of primary, isotope used or use of concomitant chemotherapy that can benefit from this application. Further prospective studies will require collaboration between multiple centers to gain sufficient high‐quality evidence.
The quality of clinician and student quality improvement reports: An analysis of 8 years of submissions
Authors: Kennedy Maureen (Shawn) , Barnsteiner Jane 
Published: June 2024

AbstractIntroductionMany papers reporting on QI projects are not publishable for a variety of reasons. We compared manuscripts submitted as QI reports between June 2014 and June 2016 (prior to publication of the revised Standards for Quality Improvement Reporting Excellence (SQUIRE 2.0) with papers submitted to the American Journal of Nursing between July 2016 and December 2022). The aim was to evaluate any changes in the quality of manuscripts and identify problems that led to rejection; we also compared the quality of students with non‐student submissions.MethodsWe conducted a non‐randomized descriptive study to evaluate 349 papers submitted as QI project reports between June 2014 and December 2022 using screening templates based on the SQUIRE 2.0 checklist and findings of the INANE Working Group on Student Papers.ResultsManuscripts designated as QI reports accepted for publication increased from 4% during 2014–2016 (T1) to 14% during 2016–2022 (T2); one student submission was accepted. There was a slight decrease in submissions designated as QI that were not QI: 36% of student submissions during T1 and 31% of student submissions during T2. Among clinician submissions, 44% in T1 designated as QI reports were not QI versus 31% submitted during T2. There was a decrease in student submissions that followed the SQUIRE guidelines (36% during T1 to 24% during T2).ConclusionsFindings demonstrate that by following the SQUIRE 2.0 guidelines, authors submit more complete manuscripts with fewer missing components. However, there are still misconceptions about what constitutes QI versus research and how to report QI initiatives. After comparing the findings from both periods, it is noteworthy that there is essentially the same level of inaccuracy and lack of acceptable manuscripts.Clinical RelevanceSharing findings from QI activities through presentations and publications is a vital way of helping spread the learnings from these projects and improve health care for a wider audience. Clinicians, academicians, and students must understand the elements of the SQUIRE guidelines and ensure that this framework is used for both designing and submitting QI projects for publication.
What is QuantCrit doing in a nice field like family science?
Authors: Williams Deadric T. , Curtis Michael G. , Boe Joshua L. , Jensen Todd M. 
Published: June 2024

AbstractFamily science is grappling with the legacy of White supremacy embedded in its theories and methodologies. This presents an opportunity to move beyond traditional theoretical perspectives and statistical approaches that have perpetuated racist assumptions about the inferiority of people of color compared to White Americans. We build on Curtis et al.'s (2022) introduction of Quantitative Criticalism by presenting quantitative critical race theory (QuantCrit) as a critical framework that combines quantitative methods and critical race theory (CRT) to examine issues of racism and race in social science research. Specifically, we (1) make an argument for why QuantCrit is needed in family science, (2) review and critique conventional approaches family scientists have used to analyze racial inequality within the family sciences, (3) offer QuantCrit as an alternative and critical strategy for the quantitative study of racial inequality in family research, and (4) provide examples of how family scientists can leverage QuantCrit to subvert underlying assumptions and practices that perpetuate continued marginalization. We discuss recent research that exhibits elements of QuantCrit in family research to showcase the value of an emerging subfield. QuantCrit provides an opportunity for family scientists studying racial inequality to promote theories, methodological strategies, and policies rooted in social justice.
The novel m6A writer methyltransferase 5 is a promising prognostic biomarker and associated with immune cell infiltration in oral squamous cell carcinoma
Authors: Muthumanickam Priyadharshini , Ramasubramanian Abilasha , Pandi Chandra , Kannan Balachander , Pandi Anitha , Ramani Pratibha , Jayaseelan Vijayashree Priyadharsini , Arumugam Paramasivam 
Published: June 2024

AbstractBackgroundEmerging research has identified the N6‐methyladenosine (m6A) modification and its regulatory enzymes, including methyltransferase 5 (METTL5), as critical players in cancer biology. However, the role of METTL5 in oral squamous cell carcinoma (OSCC) remains poorly understood.Materials and MethodsWe conducted a comprehensive study to investigate the expression and implications of METTL5 in OSCC. We recruited 76 OSCC patients to analyze METTL5 mRNA and protein expression using RT‐qPCR and western blot. Additionally, we analyzed METTL5 expression and its correlation with clinical features, patient prognosis, immune cell infiltration, and biological pathways using the TCGA‐HNSCC dataset, which primarily consists of OSCC samples.ResultsOur findings revealed significant overexpression of METTL5 in OSCC tissues compared to normal tissues. The high expression of METTL5 is associated with advanced cancer stages, higher tumor grades, nodal metastasis, and poorer patient outcomes, indicating its involvement in cancer progression. In silico functional analysis revealed that METTL5 plays a role in multiple biological pathways, highlighting its importance in cancer biology. Moreover, METTL5 has complex relationships with immune regulatory genes, suggesting its potential role in shaping the tumor immune microenvironment.ConclusionMETTL5 is a promising candidate for the prognosis and therapeutic intervention of OSCC. Its overexpression in cancer tissues, association with clinical features, and intricate links to immune regulatory networks underscore its significance in this malignancy. This study contributes to a deeper understanding of the complex factors influencing OSCC, and provides a foundation for future research and potential clinical applications.
Modulation of growth, immunity, and immune‐antioxidant gene expression in Nile tilapia, Oreochromis niloticus, culture under biofloc system by dragon fruit, Hylocereus undatus, peel powder
Authors: Xuan Chinh Le , Nguyen Vu Linh , Wannavijit Supreya , Outama Piyatida , Khongdee Nuttapon , Sutthi Nantaporn , Nguyen Viet Vuong , Hoseinifar Seyed Hossein , Srisapoome Prapansak , Van Doan Hien 
Published: June 2024

AbstractThis study examines the use of dragon fruit peel (DFP) powder as a dietary supplement on growth performance, immune responses, and gene expression of Nile tilapia, Oreochromis niloticus, cultured within biofloc systems. A total of 300 Nile tilapia fingerlings (14.64 ± 0.09 g) were subjected to five dietary treatments, with DFP added to a basal diet at doses of 0, 20, 40, 80, and 160 g kg−1 DFP. Growth and immunological responses were assessed after 4 and 8 weeks of feeding, and the transcriptional level of immune and antioxidant‐related genes was measured after 8 weeks. Fish fed diets containing DFP exhibited significantly greater weight gain, faster growth, and enhanced levels of key indicators of immunity than control fish (p < 0.05). A diet containing 40 g DFP kg−1 produced the best result in terms of growth, enhanced immune response indicators in skin mucus and blood serum, and the upregulation of IL‐1, IL‐8, LBP, GPx, GST‐α, and GSR expression (p < 0.05). Based on the quadratic regression analysis, the optimum concentration of DFP was 80 g kg−1. These findings collectively suggest that powdered DFP may serve as a promising feed supplement for Nile tilapia raised in biofloc systems.
Computing‐efficient video analytics for nighttime traffic sensing
Authors: Lashkov Igor , Yuan Runze , Zhang Guohui 
Published: June 2024

AbstractThe training workflow of neural networks can be quite complex, potentially time‐consuming, and require specific hardware to accomplish operation needs. This study presents a novel analytical video‐based approach for vehicle tracking and vehicle volume estimation at nighttime using a monocular traffic surveillance camera installed over the road. To build this approach, we employ computer vision‐based algorithms to detect vehicle objects, perform vehicle tracking, and vehicle counting in a predefined detection zone. To address low‐illumination conditions, we adapt and employ image noise reduction techniques, image binary conversion, image projective transformation, and a set of heuristic reasoning rules to extract the headlights of each vehicle, pair them belonging to the same vehicle, and track moving candidate vehicle objects continuously across a sequence of video frames. The robustness of the proposed method was tested in various scenarios and environmental conditions using a publicly available vehicle dataset as well as own labeled video data.
Pollination efficiency and the pollen–ovule ratio
Authors: Bochynek Thomas , Burd Martin 
Published: June 2024

Summary

Pollination presents a risky journey for pollen grains. Pollen loss is sometimes thought to favour greater pollen investment to compensate for the inefficiency of transport. Sex allocation theory, to the contrary, has consistently concluded that postdispersal loss should have no selective effect on investment in either sex function. But the intuitively appealing compensation idea continues to be raised despite the lack of theoretical endorsement.

We address the theoretical issue with a model that directly represents pollen loss (and ovule loss through floral demise or loss of receptivity) as rate‐dependent dynamical processes. These loss rates can be varied to examine the effect of pollination efficiency on optimal sex allocation. Pollen–ovule ratios follow from the sex allocation based on the resource costs of pollen and ovule production.

This model confirms conventional findings that pollen loss should have essentially no effect on sexual resource allocation in large, panmictic populations. Pollen limitation of seed set does not alter this conclusion.

These results force us to rethink the empirical association of pollination efficiency with low pollen–ovule ratios. This pattern could arise if efficient pollen transport commonly results in stigmatic deposition of cohorts of related pollen. Empirical evidence of correlated paternity supports this explanation.
Exosomal miR‐196a‐5p contributes to esophageal squamous cell carcinoma malignant progression by inhibiting ITM2B
Authors: Huang Min , Li Shuang , Zeng Hai , Zhu Yan , Zhang Fan , Cai Jun 
Published: June 2024

AbstractExosomes from cancer cells function as carriers to spread or transport specific microRNAs (miRNAs) to distant sites to exert their effects, but the mechanism of exosomal miRNA action in esophageal squamous cell carcinoma (ESCC) has not been fully explained. Therefore, in this study, we were interested in the impact of exosomal miR‐196a‐5p in ESCC progression. We found that miR‐196a‐5p was expressed enriched in clinical tissues, ESCC cells, and exosomes. Functionally, depletion of miR‐196a‐5p impeded ESCC cell growth, migration, and invasion, whereas overexpression of miR‐196a‐5p produced the opposite results. Moreover, enhancement of exosomal miR‐196a‐5p in recipient ESCC cells triggered more intense proliferation and migration. Mechanistically, we identified integral membrane protein 2B (ITM2B) as a direct target of miR‐196a‐5p. Silencing of ITM2B partially counteracted the inhibitory effect of miR‐196a‐5p inhibitors on the malignant phenotype of ESCC. Furthermore, in vivo, lower miR‐196a‐5p levels triggered by the introduction of antagomiR‐196a‐5p resulted in the generation of smaller volume and weight xenograft tumors. Thus, our results demonstrated novel mechanisms of exosomal and intracellular miR‐196a‐5p‐mediated ESCC growth and migration and identify the interaction of miR‐196a‐5p with ITM2B. These works might provide new targets and basis for the development of clinical treatment options for ESCC.