bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cetuximab Attenuates Its Cytotoxic and Radiosensitizing Potential by Inducing Fibronectin Biosynthesis
Authors: Eke Iris , Storch Katja , Krause Mechthild , Cordes Nils 
Published: August 2013

Abstract
Inherent and acquired resistance to targeted therapeutics continues to emerge as a major clinical obstacle. For example, resistance to EGF receptor targeting occurs commonly, more so than was expected, on the basis of preclinical work. Given emerging evidence that cancer cell–substrate interactions are important determinants of therapeutic sensitivity, we examined the impact of cell–fibronectin interactions on the efficacy of the EGF receptor antibody cetuximab, which is used widely for lung cancer treatment. Our results revealed the potential for cell–fibronectin interactions to induce radioresistance of human non–small cell lung cancer cells. Cell adhesion to fibronectin enhanced tumor cell radioresistance and attenuated the cytotoxic and radiosensitizing effects of cetuximab. Both in vitro and in vivo, we found that cetuximab treatment led to a remarkable induction of fibronectin biosynthesis. Mechanistic analyses revealed the induction was mediated by a p38–MAPK–ATF2 signaling pathway and that RNAi-mediated inhibition of fibronectin could elevate the cytotoxic and radiosensitizing potential of cetuximab. Taken together, our findings show how cell adhesion blunts cetuximab, which, by inducing fibronectin, generates a self-attenuating mechanism of drug resistance. Cancer Res; 73(19); 5869–79. ©2013 AACR.
Parental Tobacco and Alcohol Use and Risk of Hepatoblastoma in Offspring: A Report from the Children's Oncology Group
Authors: Johnson Kimberly J. , Williams Katherine S. , Ross Julie A. , Krailo Mark D. , Tomlinson Gail E. , Malogolowkin Marcio H. , Feusner James H. , Spector Logan G. 
Published: August 2013

Abstract
Background: Hepatoblastoma is a rare pediatric liver tumor that has significantly increased in incidence over the last several decades. The International Agency for Research on Cancer (IARC) recently classified hepatoblastoma as a tobacco-related cancer. Parental alcohol use has shown no association. We examined associations between parental tobacco and alcohol use around the time of pregnancy and hepatoblastoma in a large case–control study.
Methods: Maternal interviews were completed for 383 cases diagnosed in the United States during 2000–2008. Controls (n = 387) were identified through U.S. birth registries and frequency-matched to cases on birth weight, birth year, and region of residence. We used unconditional logistic regression to calculate ORs and 95% confidence intervals (CI) for associations between parental smoking and maternal drinking and offspring hepatoblastoma.
Results: We found no association between hepatoblastoma and maternal smoking at any time (OR, 1.0; 95% CI, 0.7–1.4), within the year before pregnancy (OR, 1.1; 95% CI, 0.8–1.6), early in pregnancy (OR, 1.0; 95% CI, 0.7–1.6), or throughout pregnancy (OR, 0.9; 95% CI, 0.5–1.6). We observed marginally positive associations between hepatoblastoma and paternal smoking in the year before pregnancy (OR, 1.4; 95% CI, 1.0–2.0) and during pregnancy (OR, 1.4; 95% CI, 0.9–2.0). Maternal alcohol use was not associated with hepatoblastoma.
Conclusion: Our results do not provide evidence for an etiologic relationship between maternal smoking or drinking and hepatoblastoma, and only weak evidence for an association for paternal smoking in the year before pregnancy.
Impact: Our study provides limited support for hepatoblastoma as a tobacco-related cancer; however, it remains wise to counsel prospective parents on the merits of smoking cessation. Cancer Epidemiol Biomarkers Prev; 22(10); 1837–43. ©2013 AACR.
Fecal miR-106a Is a Useful Marker for Colorectal Cancer Patients with False-Negative Results in Immunochemical Fecal Occult Blood Test
Authors: Koga Yoshikatsu , Yamazaki Nobuyoshi , Yamamoto Yoshiyuki , Yamamoto Seiichiro , Saito Norio , Kakugawa Yasuo , Otake Yosuke , Matsumoto Minori , Matsumura Yasuhiro 
Published: August 2013

Abstract
Background: Immunochemical fecal occult blood test (iFOBT) is widely used for colorectal cancer screening; however, its sensitivity is insufficient. We recently reported a fecal microRNA (miRNA) test (FmiRT) to detect colorectal cancer. In this study, we investigated a new colorectal cancer screening method combining iFOBT and FmiRT to improve the sensitivity compared with iFOBT alone.
Methods: In total, 117 colorectal cancer patients and 107 healthy volunteers were enrolled. Ten-milligram fecal samples were collected and iFOBT was conducted. Fecal RNA was extracted from residuum of iFOBT and then the expression of 14 kinds of miRNA was analyzed for the FmiRT using real-time reverse transcription PCR.
Results: Levels of fecal miR-106a expression in iFOBT+ patients and iFOBT− patients were significantly higher than in healthy volunteers (P = 0.001). The sensitivity and specificity of FmiRT using miR-106a were 34.2% and 97.2%, and those of iFOBT were 60.7% and 98.1%, respectively. The overall sensitivity and specificity of the new screening method combining iFOBT and FmiRT were 70.9% and 96.3%, respectively. One quarter of colorectal cancer patients with false-negative iFOBT seemed to be true positive upon adding FmiRT using fecal miR-106a.
Conclusions: Fecal miR-106a is a good molecular marker to identify colorectal cancer patients from among those with negative iFOBT results. FmiRT combined with iFOBT may improve the sensitivity to detect colorectal cancer.
Impact: We have shown the usefulness of fecal miR-106a to detect the colorectal cancer patients among those with negative iFOBT results. Cancer Epidemiol Biomarkers Prev; 22(10); 1844–52. ©2013 AACR.
Reproductive Factors, Heterogeneity, and Breast Tumor Subtypes in Women of Mexican Descent
Authors: Martinez Maria Elena , Wertheim Betsy C. , Natarajan Loki , Schwab Richard , Bondy Melissa , Daneri-Navarro Adrian , Meza-Montenegro Maria Mercedes , Gutierrez-Millan Luis Enrique , Brewster Abenaa , Komenaka Ian K. , Thompson Patricia A. 
Published: August 2013

Abstract
Background: Published data support the presence of etiologic heterogeneity by breast tumor subtype, but few studies have assessed this in Hispanic populations.
Methods: We assessed tumor subtype prevalence and associations between reproductive factors and tumor subtypes in 1,041 women of Mexican descent enrolled in a case-only, binational breast cancer study. Multinomial logistic regression comparing HER2+ tumors and triple-negative breast cancer (TNBC) to luminal A tumors was conducted.
Results: Compared with women with luminal A tumors, those with a later age at first pregnancy were less likely to have TNBC [OR, 0.61; 95% confidence interval (CI), 0.39–0.95], whereas those with three or more full-term pregnancies were more likely to have TNBC (OR, 1.68; 95% CI, 1.10–2.55). A lower odds of TNBC was shown for longer menstruation duration, whether before first pregnancy (OR, 0.78; 95% CI, 0.65–0.93 per 10 years) or menopause (OR, 0.79; 95% CI, 0.69–0.91 per 10 years). Patients who reported breastfeeding for more than 12 months were over twice as likely to have TNBC than luminal A tumors (OR, 2.14; 95% CI, 1.24–3.68). Associations comparing HER2+ with luminal A tumors were weak or nonexistent except for the interval between last full-term pregnancy and breast cancer diagnosis.
Conclusions: Findings show etiologic heterogeneity by tumor subtype in a population of Hispanic women with unique reproductive profiles.
Impact: Identification of etiologically distinct breast tumor subtypes can further improve our understanding of the disease and help provide personalized prevention and treatment regimens. Cancer Epidemiol Biomarkers Prev; 22(10); 1853–61. ©2013 AACR.
CD62L as a Therapeutic Target in Chronic Lymphocytic Leukemia
Authors: Burgess Melinda , Gill Devinder , Singhania Richa , Cheung Catherine , Chambers Lynne , Renyolds Brent A. , Smith Louise , Mollee Peter , Saunders Nicholas , McMillan Nigel AJ 
Published: August 2013

Abstract
Purpose: Despite advances in the treatment of chronic lymphocytic leukemia (CLL), the disease remains incurable with standard therapies and relapse is inevitable. A growing body of evidence indicates that alterations in the adhesion properties of neoplastic cells play a pivotal role in the development and progression of CLL.
Experimental Design: The expression of 71 cell surface molecules was examined on CLL peripheral blood mononuclear cells (PBMCs) over 3 weeks in culture. The most highly upregulated marker, CD62L, was examined further for expression on CD5+/CD19+ CLL cells in vitro and in lymph node and bone marrow biopsies. The prosurvival role of CD62L was examined using a functional blocking antibody and therapeutic potential evaluated by comparison with current chemotherapy agents.
Results: Blocking CD62L resulted in apoptosis of CLL cells but not PBMCs from healthy donors suggesting a novel role for CD62L in CLL cell survival. The beneficial effect of coculturing CLL cells with bone marrow stromal cells or endothelial cells does not protect CLL cells from anti-CD62L–related toxicity. Moreover, combining fludarabine or mafosfamide with the anti-CD62L in vitro produced an additive effect both with and without stromal cells.
Conclusion: This is the first reported data showing that blocking the activation and homing marker, CD62L, regulates CLL cell survival in vitro. These data also suggest that therapeutic antibodies against CD62L may provide additional clinical benefit to patients with CLL receiving current standard chemotherapy protocols. Clin Cancer Res; 19(20); 5675–85. ©2013 AACR.
Attenuation of Experimental Atherosclerosis by Interleukin-19
Authors: Ellison Stephen , Gabunia Khatuna , Kelemen Sheri E. , England Ross N. , Scalia Rosario , Richards James M. , Orr A. Wayne , Traylor James G. , Rogers Thomas , Cornwell William , Berglund Lisa M. , Goncalves Isabel , Gomez Maria F. , Autieri Michael V. 
Published: August 2013

Objective—
Interleukin-19 (IL-19) is a putative Th2, anti-inflammatory interleukin. Its expression and potential role in atherogenesis are unknown. IL-19 is not detected in normal artery and is expressed to a greater degree in plaque from symptomatic versus asymptomatic patients, suggesting a compensatory counter-regulatory function. We tested whether IL-19 could reduce atherosclerosis in susceptible mice and identified plausible mechanisms.

Approach and Results—

LDLR
−/−
mice fed an atherogenic diet and injected with either 1.0 or 10.0 ng/g per day recombinant mouse IL-19 had significantly less plaque area in the aortic arch compared with controls (
P
<0.0001). Weight gain, cholesterol, and triglyceride levels were not significantly different. Gene expression in splenocytes from IL-19–treated mice demonstrated immune cell Th2 polarization, with decreased expression of T-bet, interferon-γ, interleukin-1β, and interleukin-12β and increased expression of GATA3 and FoxP3 mRNA. A greater percentage of lymphocytes were Th2 polarized in IL-19–treated mice. Cellular characterization of plaque by immunohistochemistry demonstrated that IL-19–treated mice have significantly less macrophage infiltrate compared with controls (
P
<0.001). Intravital microscopy revealed significantly less leukocyte adhesion in wild-type mice injected with IL-19 and fed an atherogenic diet compared with controls. Treatment of cultured endothelial cells, vascular smooth muscle cells, and bone marrow–derived macrophages with IL-19 resulted in a significant decrease in chemokine mRNA and mRNA stability protein human antigen R.

Conclusions—
These data suggest that IL-19 is a potent inhibitor of experimental atherosclerosis, with diverse mechanisms including immune cell polarization, decrease in macrophage adhesion, and decrease in gene expression. This may identify IL-19 as a novel therapeutic to limit vascular inflammation.
The first record of the wolf spider subfamily Zoicinae from China (Araneae: Lycosidae), with the description of two new species
Authors: LI ZONGXU , WANG LU-YU , ZHANG ZHI-SHENG 
Published: August 2013

The subfamily Zoicinae Lehtinen & Hippa, 1979 is here first recorded from China with the description of a new species in the genus Zoica Simon, 1898, Z. unciformis sp. nov. from Wild Elephant Valley (Yunnan) and a new species in the genus Lysania Thorell, 1890, L. deangia sp. nov., from a rubber plantation in Nangsang Village (Yunnan). Lysania pygmaea Thorell, 1890 is recorded for the first time in China, from three localities in Yunnan and Guangxi and is redescribed here.
Response of Ice and Liquid Water Paths of Tropical Cyclones to Global Warming Simulated by a Global Nonhydrostatic Model with Explicit Cloud Microphysics
Authors: Yamada Yohei , Satoh Masaki 
Published: August 2013

Abstract
Cloud feedback plays a key role in the future climate projection. Using global nonhydrostatic model (GNHM) simulation data for a present-day [control (CTL)] and a warmer [global warming (GW)] experiment, the authors estimate the contribution of tropical cyclones (TCs) to ice water paths (IWP) and liquid water paths (LWP) associated with TCs and their changes between CTL and GW experiments. They use GNHM with a 14-km horizontal mesh for explicitly calculating cloud microphysics without cumulus parameterization. This dataset shows that the cyclogenesis under GW conditions reduces to approximately 70% of that under CTL conditions, as shown in a previous study, and the tropical averaged IWP (LWP) is reduced by approximately 2.76% (0.86%). Horizontal distributions of IWP and LWP changes seem to be closely related to TC track changes. To isolate the contributions of IWP/LWP associated with TCs, the authors first examine the radial distributions of IWP/LWP from the TC center at their mature stages and find that they generally increase for more intense TCs. As the intense TC in GW increases, the IWP and LWP around the TC center in GW becomes larger than that in CTL. The authors next define the TC area as the region within 500 km from the TC center at its mature stages. They find that the TC’s contribution to the total tropical IWP (LWP) is 4.93% (3.00%) in CTL and 5.84% (3.69%) in GW. Although this indicates that the TC’s contributions to the tropical IWP/LWP are small, IWP/LWP changes in each basin behave in a manner similar to those of the cyclogenesis and track changes under GW.
On the Circulation of Atlantic Water in the Arctic Ocean
Authors: Spall Michael A. 
Published: August 2013

Abstract
An idealized eddy-resolving numerical model and an analytic three-layer model are used to develop ideas about what controls the circulation of Atlantic Water in the Arctic Ocean. The numerical model is forced with a surface heat flux, uniform winds, and a source of low-salinity water near the surface around the perimeter of an Arctic basin. Despite this idealized configuration, the model is able to reproduce many general aspects of the Arctic Ocean circulation and hydrography, including exchange through Fram Strait, circulation of Atlantic Water, a halocline, ice cover and transport, surface heat flux, and a Beaufort Gyre. The analytic model depends on a nondimensional number, and provides theoretical estimates of the halocline depth, stratification, freshwater content, and baroclinic shear in the boundary current. An empirical relationship between freshwater content and sea surface height allows for a prediction of the transport of Atlantic Water in the cyclonic boundary current. Parameters typical of the Arctic Ocean produce a cyclonic boundary current of Atlantic Water of O(1 − 2 Sv; where 1 Sv ≡ 106 m3 s−1) and a halocline depth of O(200 m), in reasonable agreement with observations. The theory compares well with a series of numerical model calculations in which mixing and environmental parameters are varied, thus lending credibility to the dynamics of the analytic model. In these models, lateral eddy fluxes from the boundary and vertical diffusion in the interior are important drivers of the halocline and the circulation of Atlantic Water in the Arctic Ocean.
Adaptive Reduction of Striping for Improved Sea Surface Temperature Imagery from Suomi National Polar-Orbiting Partnership (S-NPP) Visible Infrared Imaging Radiometer Suite (VIIRS)
Authors: Bouali Marouan , Ignatov Alexander 
Published: August 2013

Abstract
The Suomi National Polar-Orbiting Partnership (S-NPP) satellite was successfully launched on 28 October 2011. It carries five new-generation instruments, including the Visible Infrared Imaging Radiometer Suite (VIIRS). The VIIRS is a whiskbroom radiometer that scans the surface of the earth using a rotating telescope assembly, a double-sided half-angle mirror, and 16 individual detectors. Substantial efforts are being made to accurately calibrate all detectors in orbit. As of this writing, VIIRS striping is reduced to levels below those seen in corresponding Terra and Aqua Moderate Resolution Imaging Spectroradiometer (MODIS) bands and meets the program specifications and requirements. However, the level 2 SST products derived from level 1 sensor data records (SDRs) thermal emissive bands still show residual striping. These artifacts reduce the accuracy of SST measurements and adversely affect cloud masking and the output of downstream applications, such as thermal front detection. To improve the quality of SST imagery derived from the VIIRS sensor, an adaptive algorithm was developed for operational use within the National Environmental Satellite, Data, and Information Service (NESDIS)’s SST system. The methodology uses a unidirectional quadratic variational model to extract stripe noise from the observed image prior to nonlocal filtering. Evaluation of the algorithm performance over an extended dataset demonstrates a significant improvement in the Advanced Clear-Sky Processor for Oceans (ACSPO) VIIRS SST image quality, with normalized improvement factors (NIF) varying between 5% and 25%.
A Biomechanical Analysis of Controllable Intraoperative Variables Affecting the Strength of Rotator Cuff Repairs at the Suture-Tendon Interface
Authors: Ponce Brent A. , Hosemann Chad D. , Raghava Parthasarathy , Tate Janet P. , Sheppard Evan D. , Eberhardt Alan W. 
Published: August 2013

Background: The tissue-suture interface remains the weakest aspect of a rotator cuff repair, highlighting the importance of identifying techniques to improve stitch strength. Choice of suture-passing devices, size of the tissue bite, and stitch configuration are variables that may influence stitch strength and therefore repair stability. Purpose: To evaluate the effect that size of the tissue penetrator device and tissue bite size have upon the holding strength of commonly used stitches. Study Design: Controlled laboratory study. Methods: Three different-sized tissue-penetrating devices, small circular, midsized circular, and large rectangular, were used to place sutures in 192 infraspinatus tendon grafts of sheep. Tissue bite sizes of either 0.5 cm or 1.0 cm for 4 different stitches, a simple, mattress, modified Mason-Allen (MMA), and massive cuff (MAC) stitch, were tested. Grafts were cyclically loaded and then loaded to failure. Mixed multivariate regression analysis was used to test the effect of instrument, bite size, and stitch configuration on peak-to-peak displacement, cyclic elongation, and load to failure. Results: The average ultimate load to failure with the smallest penetrating device was 112 N, significantly higher than with both the midsized (95 N) and large devices (91 N) ( P < .001). The average load to failure was 31 N higher for a 1.0-cm bite size when compared with a 0.5-cm bite size ( P < .001). The largest load-to-failure differences were found with the type of stitch placed: simple, 48 N; mattress, 69 N; MMA, 130 N; and MAC, 152 N (all P < .02). For simple and mattress stitches, each additional pass of the suture increased the load to failure by 21 N. In MMA and MAC stitches, an additional pass resulted in an increase in the load to failure by 50 N. Cyclic elongation did not differ by instrument type (all P > .5). The elongation of stitches with a 1.0-cm bite size was 0.14 mm higher than stitches with a 0.5-cm bite size ( P < .001). No meaningful difference in peak-to-peak displacement was seen for bite size, instrument type, or stitch construct. Conclusion: The strength of rotator cuff stitches was significantly affected by the different-sized tissue-penetrating instruments and size of the bite. However, the greatest predictor of time-zero stitch strength is the type of stitch placed. Clinical Relevance: This study highlights the importance of stitch configuration in the repair of rotator cuff tears.
Biomechanical Characteristics of 3 Pivot-Shift Maneuvers for the Anterior Cruciate Ligament–Deficient Knee
Authors: Kitamura Nobuto , Yokota Masashi , Kondo Eiji , Miyatake Shin , Nagamune Kouki , Yasuda Kazunori 
Published: August 2013

Background: A disadvantage of pivot-shift maneuvers is that the examiner has to subjectively evaluate the degree of pivot shift observed. It is unknown whether the various maneuvers are biomechanically identical. Purpose: To compare biomechanical features of 3 clinical maneuvers for the anterior cruciate ligament (ACL)–deficient knee: the pivot-shift test, the jerk test, and the N-test. Study Design: Controlled laboratory study. Methods: A total of 28 patients with an isolated ACL injury were examined by use of 3 pivot-shift maneuvers (pivot-shift test, jerk test, and N-test). An electromagnetic sensor system was used to evaluate the 3-dimensional knee kinematics of each patient’s injured and uninjured knees during each maneuver. Peak coupled anterior tibial translation (pCAT) and maximal acceleration of posterior translation (APT) were measured relative to results during a flexion-extension motion in each test. Results: The pCAT of the pivot-shift test was significantly greater than that of both the jerk test and the N-test ( P = .0020 and P < .0001, respectively); there was no statistical difference in pCAT between the jerk test and the N-test. The APT of the N-test was significantly greater than that of both the pivot-shift test and the jerk test ( P < .0001), while there was no statistical difference between the pivot-shift and the jerk tests. There was no correlation between pCAT and APT in each test. Conclusion: The pivot-shift test, jerk test, and N-test have different biomechanical characteristics to induce the pivot-shift phenomenon in the ACL-deficient knee. The pivot-shift test produced the largest side-to-side difference in pCAT, whereas the N-test provoked the largest side-to-side difference in APT. Clinical Relevance: The biomechanical differences in pivot-shift maneuvers are caused by technical differences, and clinicians should understand these biomechanical differences while practicing the maneuvers. The electromagnetic sensor system is clinically useful for quantifying the pivot-shift phenomenon.
Command filtered back-stepping control of a flexible air-breathing hypersonic flight vehicle
Authors: Ji Yuehui , Zong Qun , Zhou Hailiang 
Published: August 2013

<AQ*/>Abstract A theoretical framework of nonlinear flight control is exploited and applied to nonlinear longitudinal dynamics of a generic air-breathing hypersonic flight vehicle. A combination of novelty command filtered back-stepping technology and dynamic inversion methodology is adopted for designing a dynamic state-feedback controller that provides stable tracking of the altitude and velocity reference commands. The novel command filtered back-stepping altitude control obviates the need to compute analytic derivatives in the traditional back-stepping design, providing a simple and effective way for controlling non-linear hypersonic flight vehicle. An input-to-state stability-modular approach is presented by combining command filtered back-stepping method with sliding-mode-based integral filters, input-to-state stability analysis, and small-gain theorem. The stability analysis of the closed-loop system including the flexible dynamic, and the convergence of the system outputs are derived. The proposed control scheme is verified in simulations in a climbing maneuver case of separate velocity and altitude reference commands.