bluuebunny/crossref_metadata_2025_split huggingface dataset:
Establishment of ELISA-comparable moderate and high thresholds for anticardiolipin and anti-β2 glycoprotein I chemiluminescent immunoassays according to the 2023 ACR/EULAR APS classification criteria and evaluation of their diagnostic performance
Authors: Žigon Polona , Boštic Nika , Ambrožič Aleš , Rotar Žiga , Blokar Elizabeta , Ogrič Manca , Čučnik Saša 
Published: July 2024

Abstract

Objectives
Recently published 2023 ACR/EULAR APS classification criteria emphasize the importance of quantifying single-, double-, and triple-antiphospholipid antibody positivity, distinguishing between IgG and IgM isotypes, and delineating moderate/high levels of anticardiolipin (aCL) and anti-β2 glycoprotein I (anti-β2GPI) antibodies. We aimed to establish clinically important moderate/high thresholds for aCL and anti-β2GPI IgG/IgM chemiluminescent immunoassays (CLIA), in particular QUANTA Flash, comparable to our in-house ELISAs used for over two decades, and to evaluate their diagnostic performance.

Methods
QUANTA Flash CLIA and in-house ELISAs were used to measure aCL and anti-β2GPI IgG/IgM. Moderate thresholds for QUANTA Flash CLIA were determined using a non-parametric approach, calculating a 99th percentile on serum samples from 139 blood donors, and by mirroring the diagnostic performance of in-house ELISA on 159 patient samples.

Results
Thresholds for QUANTA Flash CLIA achieving diagnostic performance equivalent to in-house ELISAs were 40 CU for moderate and 80 CU for high levels for aCL and anti-β2GPI IgG and IgM. The assays showed good qualitative agreement, ranging from 76.10 to 91.19 %. When considering in-house ELISA results, 14 out of 80 (17.5 %) patients did not fulfill the new ACR/EULAR laboratory classification criteria, while 27 out of 80 (33.8 %) did not when considering QUANTA Flash CLIA results.

Conclusions
We determined moderate and high thresholds for aCL and anti-β2GPI IgG and IgM detected with QUANTA Flash CLIA, aligning with long-established in-house ELISA thresholds. These thresholds are crucial for seamlessly integrating of the new 2023 ACR/EULAR classification criteria into future observational clinical studies and trials.
The experience of social (in)visibility in narratives about ostracism
Authors: Konieczna Agnieszka 
Published: July 2024

Abstract
This work involves a comprehensive review of qualitative research focused on analysing the experience of social ostracism. The voices of the ostracized are essential for uncovering that subtle, small, invisible, and silent practices of social exclusion, such as not paying attention, treating someone like air, lack of interest, or being left out, are sufficiently real and painful enough for those who have to deal with them. The term “social (in)visibility” allows us to openly name feelings that are an internal response to external ostracism, but which remain unexpressed in everyday interactions. The article focuses on understanding the role of social attention and social recognition in social encounters. As the social challenges described document a set of practices that prevent engagement in social interactions and reinforce cultural otherness, the construct of “social (in)visibility” may thus provide a framework for explaining how the lack of acknowledgment of someone’s presence in an appropriate manner in a given situation initiates the process of excluding those with so-called ‘spoiled identities’ and may help reveal mechanisms of escalating negativity. The work concludes with reflections on future research areas and the practical implications of social (in)visibility within the context of social relationships, co-presence, and social encounters.
Molecular pathogenesis of microsatellite instability-high early-stage colorectal adenocarcinoma in India
Authors: Ariyannur Prasanth , Menon Veena P. , Pavithran Keechilat , Paulose Roopa R. , Joy Reenu A. , Vasudevan Damodaran M. 
Published: July 2024

Abstract

Objectives
The prevalence of microsatellite instability (MSI) subtype among all colon cancers in India is about 30 %, approximately two times more than that of western population suggesting different molecular pathogeneses.

Methods
A NanoString analysis-based Pan cancer differential expression (DE) profile was determined in a primary cohort of early-stage CRC (tumor=10, normal=7), and correlated against MSI status. Using RT-PCR, tumor-specific DE genes were validated in another cohort of MSI-high CRC (n=15).

Results
Among the most differentially expressed genes, AXIN2, ETV4, and RNF43 were tumor cell-specific signals, while a set of genes including COL11A1, COMP, INHBA, SPP1, MMP3, TLR2, and others were immune cell-specific signals, that had a differential expression between MSI and MSS groups. When overlapped with The Cancer Genome Atlas (TCGA) studies using the Tumor immune estimation resource tool (TIMER), and protein-protein interaction analysis by STRING.db, these genes were segregated to representative tumor cells and immune cells. On validation, the tumor-specific gene signals were inversely associated with TLR4 expression.

Conclusions
The differential expression distribution of AXIN2, ETV4, and RNF43 among tumor and immune cells, suggests more than one pathological subset in the MSI-H subgroup of early-stage CRC in the Indian population.
“It Would be Helpful to Know Which Textbook Teaches the ‘Dialectic’ he Advocates.” Inserting Lukács into the Neurath–Horkheimer Debate
Authors: Tripodi Paolo 
Published: July 2024

Abstract
The present article aims at providing some clarification on the Horkheimer-Neurath 1937 debate, so as to make three main claims: (a) around 1937 (even though perhaps neither in the early 1930s, at the time of his review of Mannheim’s Ideology and Utopia, nor after the Second World War, at the time of Adorno’s disenchanted statement, “the whole is the false”), Horkheimer belonged to the Hegelian-Marxist tradition stemming from Lukács’s History and Class Conscioussness (1923); (b) notwithstanding Neurath’s semantic and epistemological holism, his fallibilism, his rejection of Wertfreiheit in the social sciences, his commitment to socialism, there is still a gulf between his position and Horkheimer’s, for Neurath did not accept the main methodological claim made by the latter, namely, the Lukács-inspired view that what “constitutes the decisive difference between Marxism and bourgeois thought” is the Hegelian “point of view of totality”; (c) highlighting the main differences between Neurath’s and Lukács’s versions of Marxism – one concerning the very idea of dialectic, and the other concerning the epistemic privilege of the proletariat – can throw some light on and help understand better the distinctive features of Lukács’s Hegelianization of Marxism.
MULHERES INTELECTUAIS EM REVISTAS CULTURAIS: A PROPÓSITO DE ALMANAQUE – CADERNOS DE LITERATURA E ENSAIO
Authors: Link Martins Mariana , Fonseca Claudia Lorena 
Published: July 2024

Partindo do pressuposto de que as revistas culturais latino-americanas são objetos de investigação para compreender o contexto em que estão inseridas (CRESPO, 2011), este artigo tem como objetivo lançar um olhar sobre Almanaque – Cadernos de Literatura e Ensaio, com foco em seu décimo número, intitulado “Mulher Objeto… de Estudo”, publicado em 1979, identificando-a como um periódico que permitiu a atuação e colaboração feminina, e que abordou em suas páginas questões relacionadas às mulheres de forma coerente com as premissas feministas, contribuindo, assim, para a legitimação das mulheres brasileiras enquanto intelectuais, mesmo no contexto complexo do regime militar brasileiro e considerando a estigmatização dos estudos feministas à época. Para tanto, nos valemos das teorias de autoras feministas, como Silvia Federici e Marta Nunes da Costa, além de outros estudiosos, para refletir sobre a emergência das mulheres na cena intelectual.
Sintaxe e pandemia: uma experiência de afeto na linguagem
Authors: Diedrich Marlete Sandra , De Oliveira Marina 
Published: July 2024

Aborda-se o tema do ato narrativo como ato enunciativo, na perspectiva benvenistiana, com enfoque na relação do falante com a língua-discurso em situação particular de ensino de língua no contexto de uma turma de licenciatura em Letras, durante o ano de 2020, em plena pandemia de Covid-19. A situação particular de ensino desencadeou a produção da obra Sintaxe e Pandemia: uma experiência de afeto (2020). Pretende-se, com esse tema, refletir sobre a subjetividade no ato de narrar eventos particulares e os deslocamentos no universo da linguagem a partir desse modo de estar na língua. Estabelece-se, dessa forma, um diálogo entre os princípios enunciativos e a Linguística Aplicada, o qual permite afirmar que ato narrativo concebido como ato enunciativo revela dois deslocamentos importantes na linguagem: a relação entre o geral da língua e o particular do discurso; o poder significante da língua, capaz de fazer o mundo recomeçar ao representar o acontecimento através do ato narrativo.
LITERATURA, EDUCAÇÃO E RELAÇÕES ÉTNICO RACIAIS: UMA ANÁLISE DO CONTO O PECADO DE LIMA BARRETO
Authors: Campos Lillian Carlos , De Pinho Camila Maria Santos , Willms Elni Elisa 
Published: July 2024

Literatura, questões raciais e educação são três potentes eixos de reflexão para uma equidade na educação brasileira. A lei 10.639/03 discute o ensino da cultura africana e afro-brasileira nas escolas. Para contribuir com esse processo o objetivo do texto é analisar o conto “O Pecado” de Lima Barreto, escrito em 1924, um texto literário que evidencia as violências raciais na construção do que é ser negro no Brasil e os enlaces que essas questões desencadeiam ainda hoje. Traça-se um paralelo entre a vida do autor do ponto de vista profissional e pessoal, com as discussões de sua narrativa vivida que foi transposta para a ficção. Empresta-se de Conceição Evaristo o conceito de “escrevivências” para debater a narrativa negra enquanto potência de discussão social e de mudança coletiva. O conceito de epistemicídio para Sueli Carneiro, endossa a discussão do negro intelectual invalidado no ambiente intelectual e, Renato Noguera, auxilia na compreensão, por meio da epistemologia afroperspectivista, para pensar uma equidade na educação com potência para a libertação humana. Enquanto resultado da análise observa-se que a obra de Lima Barreto apresenta-se ainda hoje como uma crítica social à condição do negro através de uma analogia religiosa presente no conto em análise. A literatura, por sua vez, é um importante instrumento que permite aferir os desafios da negritude em espaços de intelectualidade levando a discutir as disparidades destes. Por fim, considera-se que o negro-autor é também o objeto narrado e ficcionado na sua escrita em que escreve de um local em que a literatura rompe os limites da palavra texto, para pensar a palavra-viva: ainda ouvimos a sua voz e o seu clamor!
QUANTUM THEORY OF NONLINEAR PLASMONICS DEVELOPED BY S. G. RAUTIAN
Authors: ДРАЧЕВ В.П. 
Published: July 2024

Рассмотрены резонансные свойства локального поля фрактальных кластеров металлов. Исследуются эффекты гигантского комбинационного рассеяния, усиления фотолюминесценции и нелинейных откликов. Демонстрируется, что модель Раутиана, основанная на квантовой теории нелинейности, предлагает более точное описание, чем предыдущие теории. Среди научных результатов теории Раутиана и его учеников можно выделить следующие: металлические наночастицы с диаметром <30 нм демонстрируют дискретные энергетические уровни в отличие от полупроводниковых квантовых точек; теория Раутиана предоставляет точное описание линейной части диэлектрической проницаемости, соответствующее классической модели Друде; кубическая нелинейная восприимчивость по модели Раутиана совпадает с экспериментом, указывая на вклад электронов проводимости.
Resonance properties of the local field of metal fractal clusters are considered. The effects of surface-enhanced Raman scattering, photoluminescence enhancement, and nonlinear responses are studied. It is demonstrated that the model developed by S. G. Rautian, based on the quantum theory of nonlinearity, offers a more accurate description than previous theories. Among the scientific results of the theory proposed by Rautian and his team, the following points can be highlighted: metal nanoparticles with a diameter < 30 nm exhibit discrete energy levels, in contrast to semiconductor quantum dots; Rautian’s theory provides an accurate description of the linear part of the dielectric function, corresponding to the classical Drude model; the cubic nonlinear susceptibility according to Rautian’s model is consistent with experiments, indicating the contribution of conduction electrons.
RESOLUTION ENHANCEMENT IN OPTICAL MICROSCOPY USING SUBPIXEL SHIFTS
Authors: ГУЖОВ В.И. , ИЛЬИНЫХ С.П. , АНДРЮЩЕНКО Е.В. , ХАЙДУКОВ Д.С. 
Published: July 2024

В статье рассматривается новый метод повышения разрешения в оптической микроскопии методом пространственных субпиксельных сдвигов, т. е. сдвигов на некоторую величину, меньшую, чем разрешение, обеспечиваемое объективом. Разрешение оптических микроскопов определяется типом используемых объективов. Профессиональные микроскопы имеют набор микрообъективов с различным увеличением, которые монтируются на турели, содержащие несколько объективов. Иногда целесообразнее вместо набора микрообъективов использовать один объектив, если есть возможность обеспечить субпиксельные сдвиги. Повышение пространственного разрешения осуществляется с помощью аналитического выражения для спектра сгенерированных изображений. При этом спектр функции дополняется множителем, вид которого зависит от вида апертуры объектива. Для определения высокоразрешающих элементов необходимо разделить Фурье-спектр изображения, полученного из нескольких сдвинутых на субпиксельную величину изображений, на множитель, зависящий от выбранной апертуры. Этот множитель называется апертурной функцией. Апертурная функция определяется типом используемого объектива и может являться его паспортной величиной. В статье показан экспериментальный способ калибровки объектива (получение его апертурной функции) с низким разрешением (8×) на основе изображений, полученных с помощью объективов с большим разрешением (40×). Определив апертурную функцию, можно использовать один объектив с небольшим разрешением для получения изображений с любым разрешением менее разрешения выбранного объектива с большим разрешением (40×).
The paper deals with a new method of resolution enhancement in optical microscopy by the method of spatial subpixel shifts, i.e., shifts by some value smaller than the resolution provided by the objective lens. The resolution of optical microscopes is determined by the type of objective lens used. Professional microscopes have a set of microlenses with different magnifications, which are mounted on a turret containing several lenses. It is shown that a single objective lens can be used instead of a set of microlenses if subpixel shifts can be provided. An increase in spatial resolution is provided using the subpixel shift technique. In this case, the spectrum of the feature is augmented by a multiplier, whose type depends on the type of the lens aperture. To obtain high-resolution features, it is necessary to divide the Fourier spectrum of an image formed from several subpixel shifted images by a multiplier depending on the aperture type. This multiplier is called the aperture function. The aperture function is determined by the type of the lens used and can be its passport value. The paper illustrates an experimental method of obtaining the aperture function of a low-resolution (8×) lens calibration based on images obtained with high-resolution (40×) lenses. After determining the aperture function, one low-resolution lens can be used to acquire images with a resolution smaller than that of the selected high-resolution (40×) lens.
འབྲུག་གི་བཟོ་རིག་བཅུ་གསུམ་གྱི་རྣམ་གྲངས་ལ་དཔྱདཔའི་གཏམ།
Authors: རིག་གཞུང་མཐོ་རིམ་སློབ་གྲྭ། སངས་རྒྱས་ཕུན་ཚོགས། 
Published: July 2024

བཅུད་དོན།
བཟོ་རིག་འདི་ འབྲུག་གི་ལམ་སྲོལ་དང་འབྲེལ་བའི་སྒྱུ་རྩལ་གལ་ཅན་ཅིག་ཨིན་རུང་ བཟོ་རིག་གི་རྣམ་གྲངས་རྩི་སྲོལ་ལུ་ མི་སྡེ་ནང་ལུ་གཅིག་མཚུངས་མེད་པའི་དཀའ་ངལ་ཅིག་སྦེ་ཆགས་ཏེ་འདུག། ཡིག་ཆ་ཚུ་དང་འཁྲིལཝ་ད་ རྣམ་གྲངས་རྩིས་ཐངས་མ་འདྲཝ་ལེ་ཤ་ཡོདཔ་ལས་ ཁུངས་བཙན་ཞིབ་འཚོལ་འདི་ནང་ ཆོས་འབྱུང་རྒྱལ་རབས་དང་འབྲེལ་བའི་རྩོམ་བྲིས་དང་ ཞལ་འཛོམས་གྲོས་བཅུད་ལ་སོགས་པ་ཚད་ལྡན་གྱི་ཡིག་ཆ་ཚུ་ལུ་ཁུངས་གཏུགས་ཏེ་ འབྲུག་གི་བཟོ་རིག་གི་འབྱུང་ཁུངས་དང་ རྣམ་གྲངས་ལུ་དབྱེ་དཔྱད་འབད་དེ་ཡོད། ཞིབ་འཚོལ་གྱི་གནས་སྡུད་དབྱེ་དཔྱད་དང་འཁྲིལ་བ་ཅིན་ རྒྱལ་ཁབ་ནང་ལུ་ བཟོ་རིག་གི་རིག་རྩལ་འདི་ ནང་ཆོས་མ་དར་བའི་ཧེ་མ་མོན་ཡུལ་སྦེ་གནས་པའི་དུས་སྐབས་ལས་རང་ཡོད་པའི་ཁར་ དུས་རབས་བདུན་པ་ལས་ཡར་དྲག་སོང་ཡོདཔ་མ་ཚད་ དམིགས་ལས་གྱིས་ རྒྱལ་སྲས་བསྟན་འཛིན་རབ་རྒྱས་ཀྱི་སྐབས་ལུ་ བཟོ་རིག་གི་བསྟན་པ་རྒྱ་ཆེ་དྲག་སྦེ་དར་ཁྱབ་འགྱོ་ནུག། དེ་བཟུམ་སྦེ་ དེའི་སྐབས་ལུ་བཟོ་རིག་གི་རྣམ་གྲངས་བརྩིས་སྲོལ་ཚུ་ཡོད་རུང་ བཟོ་རིག་བཅུ་གསུམ་ངོས་འཛིན་གནང་ཡོད་པའི་ལོ་རྒྱུས་མ་གསལཝ་ལས་ གནད་དོན་འདི་གི་ཐོག་ལུ་དཔྱད་ཞིབ་འབད་མི་འདི་གིས་ དུས་མཐུན་གྱི་རྣམ་གྲངས་གསལ་སྟོན་འབད་ནི་ལུ་ལྷན་ཐབས་འབདཝ་མ་ཚད་ རྒྱལ་ཁབ་ཀྱི་ལམ་སྲོལ་གལ་གནད་ཅན་ཅིག་ཨིན་པའི་བདེན་ཁུངས་གཟང་ཚུགས།
གཙོ་ཚིག། བཟོ་རིག། བཅུ་གསུམ། རྐང་གྲངས། རྣམ་གྲངས། སྒྱུ་རྩལ།
Decision-making in non-invasive neuromodulation in children
Authors: Goulardins Juliana Barbosa , Baptista Rachel Fontes , Baptista Anna Fontes , Machado Kátia do Monte-Silva , Matos Marcos Almeida 
Published: July 2024

INTRODUCTION: Electrical and magnetic stimulation of the nervous system has been used to treat cerebral palsy, autism spectrum disorder, attention deficit hyperactivity disorder, among other childhood conditions. OBJECTIVES: This infographic was designed to elucidate the decision-making process entailed in selecting neuromodulation protocols for children. METHODS: The development of this infographic was guided by the principles of several healthcare philosophies: (1) the Biopsychosocial Model of the International Classification of Functioning, Disability, and Health;1 (2) Patient- and Family-Centered Practice;2 (3) Evidence-Based Practice;3,4 and (4) the SMART model (Specific, Measurable, Attainable, Realistic/Relevant and Timely outcome) for establishing therapeutic goals.5 RESULTS: This visual tool delineated value points that should be considered before initiating any neuromodulation treatment, conceptualized within a structured framework across various levels, including screening, feasibility and safety assessment, selection of a "SMART" outcome, evaluation of complaints, protocol definition, risks clarification, assessment of benefits and cost-effectiveness, and collaborative and empowered participation of parents/caregivers. CONCLUSION: Neuromodulation protocols’ definitions involve a complex process, encompassing choices related to techniques, targets, parameters, distribution and number of sessions, and the potential incorporation of other therapeutic modalities. This process must be tailored to specific objectives to ensure that treatment can yield optimal results within the users' functional conditions. Our infographic can serve as a tool for comprehensively visualizing the entire process and making well-informed choices in a clear, concise, and organized manner. Nevertheless, it is essential to acknowledge that this model is not flawless and should be refined further to advance toward more humanized and responsible care.
Formulation and evaluation of natural lip balm
Authors: Fatima Grace X. , Himana Begam K. , Janani A. , Jayaram M. 
Published: July 2024

The formulation and evaluation of a natural lip balm with beetroot juice as the main ingredient are the main subjects of this study. Due to its natural pigments and moisturising qualities, beetroot known for its rich colour and possible health benefits is a promising ingredient in cosmetics. The research begins with the development of a formulation incorporating beetroot juice alongside other natural ingredients to create a lip balm product.Subsequently, the physical, chemical, and sensory aspects of the lip balm formulation are evaluated. The overall quality and consumer attractiveness of the product are assessed by analysing various parameters, including colour, pH, texture, fragrance, and moisturising efficacy. Furthermore, stability checks are carried out to ensure the durability and shelf-life of the lip balm under different storage conditions.The findings of this study aim to contribute to the growing demand for natural and sustainable cosmetics while providing insights into the potential benefits of utilising beetroot juice in lip care products. Ultimately, the research seeks to offer a viable alternative to conventional lip balms, promoting both health-conscious and eco-friendly beauty solutions.
Efficiency of nitrogen fertilizers and biological preparations for winter rye on soddy-podzolic soil of different cultivation status
Authors: Volkova E. S. , Shaykova T. V. , Dyatlova M. V. 
Published: July 2024

There was studied the influence of soddy-podzolic light loamy soil of different cultivation status on the agronomic efficiency of mineral fertilizers application with varying doses of nitrogen and biological preparations applied against the mineral background, in Pskov region. On moderately cultivated soil the linear dependence of grain yield on nitrogen rates was established. An increase in nitrogen doses from 20 to 80 kg a. i./ha resulted in obtaining an additional yield compared to the control variant, which is dependent on soil pH: yield growth by 6% to 42% was recorded on soil with pH of 5.6; from 8% to 73% – on soil with pH of 5.3; from 32% to 69% – on soil with pH of 5.2; from 66% to 175% – on soil with pH of 4.8. Payback from applied fertilizers rose with increasing doses of nitrogen. Soil properties also influenced the payback value. The maximum payback, 12 kg of grain per 1 kg of NPK, was recorded when N80P40K70 with split nitrogen fertilizing was applied to the soil with pH = 4.8. The introduction of biological products to the variant with mineral fertilizers (N20P40K70 + N20) contributed to an increase in grain yield : the introduction of microbiological preparation Bisolbifitis provided additional 7.55%; spraying of foliar fertilizers – 3.67%–8.78%. On the soil with long-term cultivation status the dependence of yield on the doses of applied nitrogen in the range from 20 to 80 kg a. i./ha looked like a polynomial. Maximum yield was obtained in different years when nitrogen was applied at rates from 40 and 60 kg a. i./ha. An increase in the dose of nitrogen from 20 to 40 kg was accompanied in 2019 by an increase in the yield of grain from 11.2% to 22.6%. An increase in nitrogen rates from 20 to 60 kg in 2020 and 2021 resulted in the growth of grain yield from 20% to 65%. Respectively. When the most effective doses of nitrogen were applied the payback from fertilizers was 5 kg of grain per 1 kg of NPK in 2019; 7 kg of grain per 1 kg of NPK in 2020; and 10 kg of grain per 1 kg of NPK in 2021. On the soil cultivated and improved for a long-term the effect of foliar fertilizers with biological preparations Kodamine B-Mo and K-Humate-Na was less significant (3–3.5%).