bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lattice properties of strength functions
Authors: Ramanantoanina Andriamanankasina , Titkos Tamás 
Published: July 2024

AbstractThis paper investigates an important functional representation of the cone of bounded positive semidefinite operators. It is known that the representation by strength functions turns the Löwner order into the pointwise order. However, very little is known about the structure of strength functions. Our main result says that the representation behaves naturally with the infimum and supremum operations. More precisely, we show that the pointwise minimum of two strength functions $$f_A$$

f
A

and $$f_B$$

f
B

is a strength function if and only if the infimum of A and B exists. This complements a recent result of L. Molnár stating that the pointwise maximum of $$f_A$$

f
A

and $$f_B$$

f
B

exists if and only if A and B are comparable, as this latter statement is equivalent to the existence of the supremum. The cornerstone of each argument in this paper is a fact that was discovered recently, namely that the strength function of the parallel sum A : B (which is half of the harmonic mean) equals the parallel sum of the strength functions $$f_A$$

f
A

and $$f_B$$

f
B

. We provide a new proof for this statement, and as a byproduct, in some special cases, we describe the strength function of the so-called (generalized) short.
Sediment Cover Modulates Landscape Erosion Patterns and Channel Steepness in Layered Rocks: Insights From the SPACE Model
Authors: Guryan G. J. , Johnson J. P. L. , Gasparini N. M. 
Published: July 2024

AbstractErosional perturbations from changes in climate or tectonics are recorded in the profiles of bedrock rivers, but these signals can be challenging to unravel in settings with non‐uniform lithology. In layered rocks, the surface lithology at a given location varies through time as erosion exposes different layers of rock. Recent modeling studies have used the Stream Power Model (SPM) to highlight complex variations in erosion rates that arise in bedrock rivers incising through layered rocks. However, these studies do not capture the effects of coarse sediment cover on channel evolution. We use the “Stream Power with Alluvium Conservation and Entrainment” (SPACE) model to explore how sediment cover influences landscape evolution and modulates the topographic expression of erodibility contrasts in horizontally layered rocks. We simulate river evolution through alternating layers of hard and soft rock over million‐year timescales with a constant and uniform uplift rate. Compared to the SPM, model runs with sediment cover have systematically higher channel steepness values in soft rock layers and lower channel steepness values in hard rock layers. As more sediment accumulates, the contrast in steepness between the two rock types decreases. Effective bedrock erodibilities back‐calculated assuming the SPM are strongly influenced by sediment cover. We also find that sediment cover can significantly increase total relief and timescales of adjustment toward landscape‐averaged steady‐state topography and erosion rates.
Machine Learning‐Based Clustering of Oceanic Lagrangian Particles: Identification of the Main Pathways of the Labrador Current
Authors: Jutras M. , Planat N. , Dufour C. O. , Talbot L. C. 
Published: July 2024

AbstractModeled geospatial Lagrangian trajectories are widely used in Earth Science, including in oceanography, atmospheric science and marine biology. The typically large size of these data sets makes them arduous to analyze, and their underlying pathways challenging to identify. Here, we show that we can use a machine learning unsupervised k‐means++ clustering method combined with expert aggregation of clusters to identify the pathways of the Labrador Current from a large set of modeled Lagrangian trajectories. The presented method requires simple pre‐processing of the data, including a Cartesian correction on longitudes and a principal component analysis reduction. The clustering is performed in a kernelized space and uses a larger number of clusters than the number of expected pathways. To identify the main pathways, similar clusters are grouped into pathway categories by experts in the circulation of the region of interest. We find that the Labrador Current mainly follows a westward‐flowing and an eastward retroflecting pathway (20% and 50% of the flow, respectively) that compensate each other through time in a see‐saw behavior. These pathways experience a strong variability (representing through time 4%–42% and 24%–73% of the flow, respectively). Two thirds of the retroflection occurs at the tip of the Grand Banks, and one quarter at Flemish Cap. The westward pathway is mostly fed by the on‐shelf branch of the Labrador Current, and the eastward pathway by the shelf‐break branch. Among the pathways of secondary importance, we identify a previously unreported one that feeds the subtropics across the Gulf Stream.
Soil Moisture‐Temperature Coupling Increases Population Exposure to Future Heatwaves
Authors: Zhou Jingwei , Teuling Adriaan J. , Seneviratne Sonia I. , Hirsch Annette L. 
Published: July 2024

AbstractHeatwaves have significant effects on ecosystems and human health. Human habitability is impacted severely as human exposure to heatwaves is projected to increase, however, the contribution of soil moisture effects to the increased exposure is unknown. We use data from four climate models, in which two experiments are used to isolate soil moisture effects and in this way to examine projected changes of soil moisture contributions to projected increases in heatwave events. Contributions from soil moisture to future population exposure to heatwaves are also investigated. With soil moisture effects combined with global warming, the longest yearly heatwaves are found to increase by up to 20 days, intensify by up to 2°C in mean temperature, with an increasing of frequency by 15% (the percentage relative to the total number of days for a year) over most mid‐latitude land regions by 2040–2070 under the SSP585 high emissions scenario. Furthermore, soil moisture changes are found to have a significant role in projected increases of multiple heatwave characteristics regionally compared with the global land area and contribute to more global population exposed to heatwaves.
Deep Multimodal Learning for Seismoacoustic Fusion to Improve Earthquake‐Explosion Discrimination Within the Korean Peninsula
Authors: Ronac Giannone Miro , Arrowsmith Stephen , Park Junghyun , Stump Brian , Hayward Chris , Larson Eric , Che Il‐Young 
Published: July 2024

AbstractRecent geophysical studies have highlighted the potential utility of integrating both seismic and infrasound data to improve source characterization and event discrimination efforts. However, the influence of each of these data types within an integrated framework is not yet well‐understood by the geophysical community. To help elucidate the role of each data type within a merged structure, we develop a neural network which fuses seismic and infrasound array data via a gated multimodal unit for earthquake‐explosion discrimination within the Korean Peninsula. Model performance is compared before and after adding the infrasound branch. We find that the seismoacoustic model outperforms the seismic model, with the majority of the improvements stemming from the explosions class. The influence of infrasound is quantified by analyzing gated multimodal activations. Results indicate that the model relies comparatively more on the infrasound branch to correct seismic predictions.
PHF6 suppresses self-renewal of leukemic stem cells in AML
Authors: Jalnapurkar Sapana S. , Pawar Aishwarya S. , George Subin S. , Antony Charles , Somers Patrick , Grana Jason , Feist Victoria K. , Gurbuxani Sandeep , Paralkar Vikram R. 
Published: July 2024

AbstractAcute myeloid leukemia is characterized by uncontrolled proliferation of self-renewing myeloid progenitors accompanied by a differentiation arrest. PHF6 is a chromatin-binding protein mutated in myeloid leukemias, and its isolated loss increases mouse HSC self-renewal without malignant transformation. We report here that Phf6 knockout increases the aggressiveness of Hoxa9-driven AML over serial transplantation, and increases the frequency of leukemia initiating cells. We define the in vivo hierarchy of Hoxa9-driven AML and identify a population that we term the “LIC-e” (leukemia initiating cells enriched) population. We find that Phf6 loss expands the LIC-e population and skews its transcriptome to a more stem-like state; concordant transcriptome shifts are also observed on PHF6 knockout in a human AML cell line and in PHF6 mutant patient samples from the BEAT AML dataset. We demonstrate that LIC-e accumulation in Phf6 knockout AML occurs not due to effects on cell cycle or apoptosis, but due to an increase in the fraction of its progeny that retain LIC-e identity. Our work indicates that Phf6 loss increases AML self-renewal through context-specific effects on leukemia stem cells.
Highly selective urea electrooxidation coupled with efficient hydrogen evolution
Authors: Zhan Guangming , Hu Lufa , Li Hao , Dai Jie , Zhao Long , Zheng Qian , Zou Xingyue , Shi Yanbiao , Wang Jiaxian , Hou Wei , Yao Yancai , Zhang Lizhi 
Published: July 2024

AbstractElectrochemical urea oxidation offers a sustainable avenue for H2 production and wastewater denitrification within the water-energy nexus; however, its wide application is limited by detrimental cyanate or nitrite production instead of innocuous N2. Herein we demonstrate that atomically isolated asymmetric Ni–O–Ti sites on Ti foam anode achieve a N2 selectivity of 99%, surpassing the connected symmetric Ni–O–Ni counterparts in documented Ni-based electrocatalysts with N2 selectivity below 55%, and also deliver a H2 evolution rate of 22.0 mL h–1 when coupled to a Pt counter cathode under 213 mA cm–2 at 1.40 VRHE. These asymmetric sites, featuring oxygenophilic Ti adjacent to Ni, favor interaction with the carbonyl over amino groups in urea, thus preventing premature resonant C⎓N bond breakage before intramolecular N–N coupling towards N2 evolution. A prototype device powered by a commercial Si photovoltaic cell is further developed for solar-powered on-site urine processing and decentralized H2 production.
Exploring superionic conduction in lithium oxyhalide solid electrolytes considering composition and structural factors
Authors: Hussain Fiaz , Zhu Jinlong , Zhao Yusheng , Xia Wei 
Published: July 2024

AbstractLithium (Li) oxyhalides have emerged as promising solid electrolyte candidates for all-solid-state batteries (ASSBs) due to their superior ionic conductivity and excellent cathode capability. However, the mechanism of Li transport in oxyhalides has remained unclear due to the complex nature of these compounds, which often comprise multiple phases such as crystalline and amorphous structures. Herein, a first-principles study using density functional theory and ab initio molecular dynamic simulation is performed to gain a theoretical insight into the structural behavior and conduction pathway in oxyhalide electrolytes. Li2.5ZrCl5.5O0.5 electrolyte, as a case of study, is comprehensively investigated by considering various phases. It’s revealed that the $${\rm{P}}\bar{3}{\rm{m}}1$$

P

3

̅

m
1

phase is energetically more stable and exhibits one order of magnitude higher Li conductivity compared to the C2/m phase among potential crystalline phases (1.63 mS cm−1 versus 0.24 mS cm−1 at room temperature). Interestingly, an amorphous phase with even higher ionic conductivity (~40 mS cm−1) can be generated by creating LiCl-deficient Li-Zr-O-Cl compounds. The remarkably high ionic conductivity suggests that the amorphous structure is likely the dominant conducting pathway, facilitating fast Li transport due the weak bonding between Li and other atoms. Cl anion mobility is also observed in the amorphous phase through mean square displacement (MSD) calculation, although further analyses revealed this to be localized vibration. This study sheds light on the nature of oxychloride structures and promotes a deeper understanding of the superionic conduction mechanism in oxychlorides, which will contribute to the development of advanced solid electrolytes and ASSBs.
Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia
Authors: Zhao Qiannan , Gao Ziyang , Yu Wei , Xiao Yuan , Hu Na , Wei Xia , Tao Bo , Zhu Fei , Li Siyi , Lui Su 
Published: July 2024

AbstractPrevious studies that focused on univariate correlations between neuroanatomy and cognition in schizophrenia identified some inconsistent findings. Moreover, antipsychotic medication may impact the brain-behavior profiles in affected individuals. It remains unclear whether unmedicated and medicated individuals with schizophrenia would share common neuroanatomy-cognition associations. Therefore, we aimed to investigate multivariate neuroanatomy-cognition relationships in both groups. A sample of 59 drug-naïve individuals with first-episode schizophrenia (FES) and a sample of 115 antipsychotic-treated individuals with schizophrenia were finally included. Multivariate modeling was conducted in the two patient samples between multiple cognitive domains and neuroanatomic features, such as cortical thickness (CT), cortical surface area (CSA), and subcortical volume (SV). We observed distinct multivariate correlational patterns between the two samples of individuals with schizophrenia. In the FES sample, better performance in token motor, symbol coding, and verbal fluency tests was associated with greater thalamic volumes but lower CT in the prefrontal and anterior cingulate cortices. Two significant multivariate correlations were identified in antipsychotic-treated individuals: 1) worse verbal memory performance was related to smaller volumes for the most subcortical structures and smaller CSA mainly in the temporal regions and inferior parietal lobule; 2) a lower symbol coding test score was correlated with smaller CSA in the right parahippocampal gyrus but greater volume in the right caudate. These multivariate patterns were sample-specific and not confounded by imaging quality, illness duration, antipsychotic dose, or psychopathological symptoms. Our findings may help to understand the neurobiological basis of cognitive impairments and the development of cognition-targeted interventions.
Association between self-reported and objectively assessed physical functioning in the general population
Authors: Moser Nicola , Sahiti Floran , Gelbrich Götz , Cejka Vladimir , Kerwagen Fabian , Albert Judith , Frantz Stefan , Heuschmann Peter U. , Störk Stefan , Morbach Caroline 
Published: July 2024

AbstractKnowledge about a patient’s physical fitness can aid in medical decision-making, but objective assessment can be challenging and time-consuming. We aimed to investigate the concordance of self-reported health status and physical functioning with the 6 minute walking distance (6MWD) as objective measure of physical performance. The prospective characteristics and course of heart failure stages A/B and determinants of progression (STAAB) cohort study iteratively follows a representative sample of residents of the city of Würzburg, Germany, aged 30–79 years, without a history of heart failure (HF). The 6MWD was measured in 2752 individuals (aged 58 ± 11 years, 51% women) from a population-based cohort under strictly standardized conditions. Self-reported health status and physical functioning were assessed from items of the short form 36 (SF-36). After the respective classification of self-reported health status and physical functioning into ‘good’, ‘moderate’, and ‘poor’, we determined the association of these categories with 6MWD by applying a generalized linear model adjusted for age and sex. Prevalence of self-reported good/moderate/poor general health and physical functioning was 41/52/7% and 45/48/7%, respectively. Mean 6MWD in the respective categories was 574 ± 70/534 ± 76/510 ± 87 m, and 574 ± 72/534 ± 73/490 ± 82 m, with significant sex-specific differences between all categories (all p < 0.001) as well as significant differences between the respective groups except for the categories ‘moderate’ and ‘poor’ health status in men. This cross-sectional analysis revealed a strong association between self-reported health status and physical functioning with the objective assessment of 6MWD, suggesting that physicians can rely on their patients’ respective answers. Nevertheless, sex-specific perception and attribution of general health and physical functioning deserve further in-depth investigation. Decision-making based on self-reported health requires prospective evaluation in population-based cohorts as well as adult inpatients.
The association between family doctor contract services and the health of middle-aged and older people in China: an instrumental variables analysis
Authors: Zhang Weile , Su Min , Li Dongxu , Yang Fan , Li Zhengrong 
Published: July 2024

AbstractPrevious research on the association between Family Doctor Contract Services (FDCS) and health has only considered a single indicator of health and has not considered the endogeneity of independent variables. This study aimed to evaluate the association from a multidimensional perspective of the health of middle-aged and older people using the instrumental variables method and determine the underlying mechanisms. Using data from the 2018 China Health and Retirement Longitudinal Study surveys, a total of 19,438 sample was obtained. Health was measured by health related-quality of life (HR-QoL), subjective well-being, and cognitive function. The instrumental variables method was used to estimate the association. Mediation analysis was employed to analyze the underlying mechanisms. The results of the instrumental variables method showed a correlation between FDCS and health, such as HR-QoL (η = 33.714, p < 0.01), subjective well-being (η = 1.106, p < 0.05), and cognitive function (η = 4.133, p < 0.05). However, we found no evidence that FDCS improved physical health. We also identified reduced utilization of healthcare services and increased social activities as mediators of the effect of FDCS on health. The Chinese government should improve incentive-based initiatives to improve the quality of FDCS. Moreover, more attention needs to be paid to the multidimensional health of middle-aged and older people, especially vulnerable groups, such as older individuals and those in rural areas.
State-of-the-art sleep arousal detection evaluated on a comprehensive clinical dataset
Authors: Ehrlich Franz , Sehr Tony , Brandt Moritz , Schmidt Martin , Malberg Hagen , Sedlmayr Martin , Goldammer Miriam 
Published: July 2024

AbstractAiming to apply automatic arousal detection to support sleep laboratories, we evaluated an optimized, state-of-the-art approach using data from daily work in our university hospital sleep laboratory. Therefore, a machine learning algorithm was trained and evaluated on 3423 polysomnograms of people with various sleep disorders. The model architecture is a U-net that accepts 50 Hz signals as input. We compared this algorithm with models trained on publicly available datasets, and evaluated these models using our clinical dataset, particularly with regard to the effects of different sleep disorders. In an effort to evaluate clinical relevance, we designed a metric based on the error of the predicted arousal index. Our models achieve an area under the precision recall curve (AUPRC) of up to 0.83 and F1 scores of up to 0.81. The model trained on our data showed no age or gender bias and no significant negative effect regarding sleep disorders on model performance compared to healthy sleep. In contrast, models trained on public datasets showed a small to moderate negative effect (calculated using Cohen's d) of sleep disorders on model performance. Therefore, we conclude that state-of-the-art arousal detection on our clinical data is possible with our model architecture. Thus, our results support the general recommendation to use a clinical dataset for training if the model is to be applied to clinical data.
Early oxidative stress and DNA damage in Aβ-burdened hippocampal neurons in an Alzheimer’s-like transgenic rat model
Authors: Foret Morgan K. , Orciani Chiara , Welikovitch Lindsay A. , Huang Chunwei , Cuello A. Claudio , Do Carmo Sonia 
Published: July 2024

AbstractOxidative stress is a key contributor to AD pathology. However, the earliest role of pre-plaque neuronal oxidative stress, remains elusive. Using laser microdissected hippocampal neurons extracted from McGill-R-Thy1-APP transgenic rats we found that intraneuronal amyloid beta (iAβ)-burdened neurons had increased expression of genes related to oxidative stress and DNA damage responses including Ercc2, Fancc, Sod2, Gsr, and Idh1. DNA damage was further evidenced by increased neuronal levels of XPD (Ercc2) and γH2AX foci, indicative of DNA double stranded breaks (DSBs), and by increased expression of Ercc6, Rad51, and Fen1, and decreased Sirt6 in hippocampal homogenates. We also found increased expression of synaptic plasticity genes (Grin2b (NR2B), CamkIIα, Bdnf, c-fos, and Homer1A) and increased protein levels of TOP2β. Our findings indicate that early accumulation of iAβ, prior to Aβ plaques, is accompanied by incipient oxidative stress and DSBs that may arise directly from oxidative stress or from maladaptive synaptic plasticity.
Reduced risk for Omicron SARS-CoV-2 infection observed in older adults with hybrid immunity
Authors: Pallett Scott J C , Heskin Jospeh , Keating Fergus , Tuck Jeremy , Mazzella Andrea , Randell Paul , Rayment Micahel , Jones Rachael , Mughal Nabeela , Davies Gary W , O’Shea Matthew K , Moore Luke S P 
Published: July 2024

Abstract

Background
Hybrid SARS-CoV-2 immunity may provide longer duration protection against severe SARS-CoV-2 infection and hospitalisation than purely vaccine-derived immunity. Older adults represent a high-risk group for severe disease, yet available data is skewed towards younger adults.

Methods
A prospective longitudinal study at a large London long-term care facility (LTCF) was conducted from March 2020 to April 2022 to assess the effect of hybrid versus vaccine-only immunity on SARS-CoV-2 infection in older adults during Omicron variant dominance. Hybrid immunity was assessed by a combination of SARS-CoV-2 polymerase chain reaction testing weekly (asymptomatic screening) and as required (symptomatic testing), as well as serial SARS-CoV-2 serology.

Results
280 participants (median age 82 yrs, IQR 76–88 yrs; 95.4% male) were followed up. 168/280 (60%) had evidence of hybrid immunity prior to the Omicron variant wave. Participants with hybrid immunity had substantially lower odds of acquiring COVID-19 infection during the Omicron wave compared to those with vaccine-only immunity (unadjusted odds ratio 0.26, 95% CI 0.14–0.47, chi-squared P &lt; .0001). Participants with hybrid immunity had an odds ratio of 0.40 (0.19–0.79) for asymptomatic infection and 0.15 (0.06–0.34) for symptomatic infection (Likelihood ratio test, P &lt; .0001).

Discussion
Our data highlight potential opportunities to target ongoing booster vaccination campaigns for those most at risk of severe infection. Reporting of data in older adults will be of particular value to examine the effect of hybrid immunity as new variants continue to emerge and vaccination strategies evolve.