bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute myeloid leukemia with gastric carcinoma: A case report of a double malignancy
Authors: Wan Qiuxia , Chen Yongzhen , Wang Suyun 
Published: August 2024

Rationale:
Multiple primary cancers (MPC) are malignant tumors that manifest as multiple primary tumors diagnosed in the same patient, either simultaneously or sequentially. Billroth first proposed the concept in 1889. Here, we report a rare case of untreated acute myeloid leukemia (AML) and adenocarcinoma of the cardia.

Patient concerns:
A 58-year-old male with muscle and joint pain for >1 month was admitted to the hospital with severe chest pain for 3 hours on July 14, 2023. The patient had chest tightness, shortness of breath, and dyspnea. The skin, mucosa, and lips of the patient were slightly pale and the sternum had mild tenderness. Other systemic examinations did not reveal any obvious abnormalities. The results of routine blood tests on admission were as follows: white blood cells, 7.46 × 109/L; red blood cells, 2.32 × 1012/L; hemoglobin, 90 g/L; and platelets, 62 × 109/L.

Diagnosis:
The patient was diagnosed with acute myeloid leukemia (FLT3, DNMT3A, U2AF1, and SMC3 mutations; KMT2A amplification; high-risk) and adenocarcinoma of the cardia.

Interventions:
The patient was treated with azacitidine + Veneckla chemotherapy, and through precise regulation, the patient survived the period of bone marrow suppression. He was unable to achieve complete relief and finally underwent allogeneic hematopoietic stem cell transplantation in February 2024.

Outcomes:
Bone marrow cytology and minimal residual disease analysis indicated complete relief on April 22, 2024, with the bone marrow exhibiting complete chimerism (99.63%). The patient and his family members decided to seize the opportunity to perform radical surgical treatment for gastric cancer on May 16, 2024.

Lessons:
The development of medicine, especially in oncology, has led to an increased possibility of developing multiple cancers. Clinically, some doctors may not be aware of the existence of multiple primary cancers, especially simultaneous carcinomas, which can be easily missed or misdiagnosed.
Microbacterium humicola sp. nov., Microbacterium terrisoli sp. nov., Paenibacillus pedocola sp. nov., Paenibacillus silviterrae sp. nov., Flavobacterium terrisoli sp. nov., and Aquabacterium humicola sp. nov., isolated from soil
Authors: Lee Hyosun , Chaudhary Dhiraj Kumar , Lee Ki-Eun , Cha In-Tae , Chi Won-Jae , Kim Dong-Uk 
Published: August 2024

Four Gram-stain-positive and two Gram-stain-negative bacterial strains, designated as W4T, FW7T, TW48T, UW52T, PT-3T, and RJY3T, were isolated from soil samples collected from the Republic of Korea. The 16S rRNA gene sequence analysis showed that strains W4T and FW7T belonged to the genus Microbacterium, strains TW48T and UW52T were affiliated to the genus Paenibacillus, strain PT-3T was related to the genus Flavobacterium, and strain RJY3T was associated with the genus Aquabacterium. The closest phylogenetic taxa to W4T, FW7T, TW48T, UW52T, PT-3T, and RJY3T were Microbacterium bovistercoris NEAU-LLET (97.7 %), Microbacterium protaetiae DFW100M-13T (97.9 %), Paenibacillus auburnensis JJ-7T (99.6 %), Paenibacillus allorhizosphaerae JJ-447T (95.7 %), Flavobacterium buctense T7T (97.1 %), and Aquabacterium terrae S2T (99.5 %), respectively. Average nucleotide identity and digital DNA–DNA hybridization values between the novel strains and related reference type strains were <95.0 % and <70.0 %, respectively. The major cellular fatty acid in strains W4T, FW7T TW48T, and UW52T was antiso-C15 : 0. Similarly, strain PT-3T revealed iso-C15 : 0, iso-C15 : 1 G, iso-C17 : 0 3-OH, and iso-C15 : 0 3-OH as its principal fatty acids. On the other hand, RJY3T exhibited summed feature 3 (C16 : 1
ω7c and/or C16 : 1
ω6c), C16 : 0, summed feature 8 (C18 : 1
ω7c and/or C18 : 1
ω6c), and C12 : 0 as its predominant fatty acids. Overall, the polyphasic taxonomic data indicated that strains W4T, FW7T, TW48T, UW52T, PT-3T, and RJY3T represent novel species within the genera Microbacterium, Paenibacillus, Flavobacterium, and Aquabacterium. Accordingly, we propose the names Microbacterium humicola sp. nov., with the type strain W4T (=KCTC 49888T=NBRC 116001T), Microbacterium terrisoli sp. nov., with the type strain FW7T (=KCTC 49859T=NBRC 116000T), Paenibacillus pedocola sp. nov., with the type strain TW48T (=KCTC 43470T=NBRC 116017T), Paenibacillus silviterrae sp. nov., with the type strain UW52T (=KCTC 43477T=NBRC 116018T), Flavobacterium terrisoli sp. nov., with the type strain PT-3T (=KCTC 92106T=NBRC 116012T), and Aquabacterium humicola sp. nov., with the type strain RJY3T (=KCTC 92105T=NBRC 115831T).
Multipoint Stimulation Motor Unit Number Estimation of the Extensor Indicis and Anconeus after Cervical Spinal Cord Injury
Authors: Adewuyi Adenike A. , Hashemi Mahdis , Khanna Shreyaa , Berger Michael J. , Franz Colin K. 
Published: August 2024

ABSTRACTIntroductionThe health of infralesional lower motor neurons (LMNs) after a cervical spinal cord injury is frequently overlooked, despite its critical role in mediating effective clinical interventions for improving arm and hand function. Prior studies suggest high frequencies of infralesional lower motor abnormalities in muscles that are potential targets for nerve transfer surgery, a procedure that has the potential to restore upper limb function.MethodsIn this prospective, two-center cohort study, we used multipoint stimulation motor unit number estimation (MPS-MUNE) to evaluate the number of motor units in clinically relevant infralesional muscles, including the predominantly C7-innervated anconeus and the predominantly C8-innervated extensor indicis (EI) in 15 individuals with cervical spinal cord injury (26 limbs) and 17 healthy controls.ResultsBoth CMAP and MUNE values were significantly lower (p < 0.05) for those with cervical spinal cord injury (EI CMAP: 2.0 mV±1.57, EI MUNE: 33±30.5, Anconeus CMAP:2.7 mV±1.9, Anconeus MUNE: 39±50.6) versus controls (EI CMAP: 6.6mV±1.0, EI MUNE:137±33.9, Anconeus CMAP:6.6 mV±1.3, Anconeus MUNE: 146 ±42.3). The test-retest reliability as measured by intraclass correlation coefficient and confidence interval (CI) for the EI and anconeus were 0.84 (CI: 0.45-0.95) and 0.78 (CI: 0.36-0.93), respectively.DiscussionThis study shows significant loss of infralesional motor units after cervical spinal cord injury. We demonstrate the potential utility of MPS-MUNE for evaluating the health of LMNs. The LMN abnormalities observed underscore the significance of this approach to evaluating potential targets for nerve transfer surgery for the restoration of upper limb function.
The mammalian Ire1 inhibitor, 4µ8C, exhibits broad anti-Aspergillusactivityin vitroand in a treatment model of fungal keratitis
Authors: Kamath Manali M. , Adams Emily M. , Lightfoot Jorge D. , Wells Becca L. , Fuller Kevin K. 
Published: August 2024

AbstractObjectiveThe fungal unfolded protein response consists of a two-component relay in which the ER-bound sensor, IreA, splices and activates the mRNA of the transcription factor, HacA. Previously, we demonstrated thathacAis essential forAspergillus fumigatusvirulence in a murine model of fungal keratitis (FK), suggesting the pathway could serve as a therapeutic target. Here we investigate the antifungal properties of known inhibitors of the mammalian Ire1 protein bothin vitroand in a treatment model of FK.MethodsThe antifungal activity of Ire1 inhibitors was tested against conidia of severalA. fumigatusisolates by a microbroth dilution assay and against fungal biofilm by XTT reduction. The influence of 4μ8C onhacAmRNA splicing inA. fumigatuswas assessed through gel electrophoresis and qRT-PCR of UPR regulatory genes. The toxicity and antifungal profile of 4μ8C in the cornea was assessed by applying drops to uninfected orA. fumigatus-infected corneas 3 times daily starting 4 hours post-inoculation. Corneas were evaluated daily through slit-lamp imaging and optical coherence tomography, or at endpoint through histology or fungal burden quantification via colony forming units.ResultsAmong six Ire1 inhibitors screened, the endonuclease inhibitor 4μ8C displayed the strongest antifungal profile with an apparent fungicidal action. The compound both blocked conidial germination and hyphal metabolism ofA. fumigatusAf293 in the same concentration range that blockedhacAsplicing and UPR gene induction (60-120 µM). Topical treatment of sham-inoculated corneas with 0.5 and 2.5 mM 4μ8C did not impact corneal clarity, but did transiently inhibit epithelialization of corneal ulcers. Relative to vehicle-treated Af293-infected corneas, treatment with 0.5 and 2.5 mM drug resulted in a 50% and >90% reduction in fungal load, respectively, the latter of which corresponded to an absence of clinical signs of infection or corneal pathology.ConclusionThein vitrodata suggest that 4μ8C displays antifungal activity againstA. fumigatusthrough the specific inhibition of IreA. Topical application of the compound to the murine cornea can furthermore block the establishment of infection, suggesting this class of drugs can be developed as novel antifungals that improve visual outcomes in FK patients.
Injection and confinement of positron bunches in a magnetic dipole trap
Authors: Deller A. , von der Linden J. , Nißl S. , Michishio K. , Oshima N. , Higaki H. , Stenson E. V. 
Published: August 2024

We demonstrate the efficient injection of a pulsed positron beam into a magnetic dipole trap and investigate the ensuing particle dynamics in the inhomogeneous electric and magnetic fields. Bunches of ∼105e+ were transferred from a buffer-gas trap into the field of a permanent magnet using a lossless E×B drift technique. The Δt≈0.2µs pulses were short compared to the toroidal rotation period, τd≈16µs, and e+ confinement time, τc≈0.6 s. The redistribution dynamics were studied by measuring the delayed γ-ray emission as the trap was emptied. This work extends the record for the number of low-energy positrons held in a dipole trap by two orders of magnitude and represents a significant advance toward the confinement of an electron-positron pair plasma.

Published by the American Physical Society
2024
A dynamic, two-way, individual-level, process-oriented framework for emergent leadership: modeling lateral influence in teams
Authors: Tabassum Marya , Raziq Muhammad Mustafa , Sarwar Naukhez , Wahaj Zujaja , Ikramullah Malik 
Published: August 2024

PurposeEmergent leadership is a relatively new phenomenon, suggesting that leaders emerge from within teams without having a formal leadership assigned role. While emergent leadership has much relevance in today's organizations transitioning from vertical to horizontal leadership, there is a paucity of research about the process of emergent leadership that enables team members to become influential within teams.Design/methodology/approachUsing purposive sampling, we interview 40 individuals in nine agile teams working in five Information Technology firms.FindingsWe identify various traits, experiences, behaviors, skills, and abilities of emergent leaders. Broadly, we conclude that an emergent leader serves as a “detail-oriented structure” or a “big picture coordinator.” Based on the findings, we propose a leadership emergence process that details how team members gain status and emerge as leaders, as well as the factors that can cause them to lose that status and return to becoming a regular team member. Furthermore, we introduce a model that demonstrates how technical expertise and personality traits interact, influencing team dynamics and facilitating the emergence of leaders within a team.Originality/valueWe contribute to the literature on emergent leadership by conceptualizing lateral influence and a leadership emergence process. We also extend the agile leadership literature and address some calls for empirical studies to understand the leadership dynamics in agile teams. We also show some limitations of the existing approaches and offer some useful insights.
Effect of monetary policy transmission on the use-based classification of manufacturing industry in India: an empirical evidence
Authors: Sahoo Mrutyunjaya , Mohanty Shiba Prasad , Sahu Praveen 
Published: August 2024

Purpose
This study aims to investigate the effect of monetary policy transmission on the use-based classification of manufacturing industries in India, an integral aspect influencing the overall economic growth of the nation.

Design/methodology/approach
The empirical study applies a panel autoregressive distributed lag model to examine the relationship/association between monetary policy transmission mechanism and the output of manufacturing industries in the long run and short run.

Findings
In the long run, the findings reveal a negative association between money supply and manufacturing industries’ output, indicating that an increase in money supply corresponds to a decrease in manufacturing output. Conversely, a positive relationship is observed between manufacturing industries’ output and banks’ credit, indicating that an increase in bank credit leads to a corresponding increase in manufacturing output. In the short run, the results highlight a significant positive relationship between manufacturing output and monetary policy transmission variables, including money supply, statutory liquidity ratio, real exchange rate and foreign direct investment. The use-based classification of manufacturing industries such as primary goods, capital goods and intermediate goods exhibits greater responsiveness to monetary policy shocks than consumer durables and non-durables goods.

Research limitations/implications
Policymakers are advised to regulate credit expansion to support the industry without risking financial instability, with key recommendations including stimulating consumer demand and adopting sector-specific policies to promote sustainable growth across diverse manufacturing sectors.

Originality/value
India, being a developing economy, efficient monetary policy transmission is crucial for boosting manufacturing output and employment. Nevertheless, there has been a scarcity of research concentrated on this pivotal intersection. This study aims to fill that gap, providing fresh insights into how monetary policy affects the growth of the manufacturing industry.
The impact of the CEO’s Islamic religiosity on tax aggressive behavior in family firms
Authors: Abu-Rajab Luai , Steijvers Tensie , Corten Maarten , Lybaert Nadine , Alsharairi Malek 
Published: August 2024

Purpose
The authors investigate the influence of CEOs’ Islamic religiosity on the level of tax aggressiveness within private family firms. In addition, this study aims to explore the moderating role of the CEO's ownership stake in the firm and the payment of Zakat.

Design/methodology/approach
The authors gathered data through surveys completed by 199 CEOs of Jordanian Islamic family firms. These survey results, along with financial statements, were used for multiple ordinary least squares regression analyses.

Findings
The results of this study reveal a negative relation between the extent of Islamic religiosity of the CEO and the level of tax aggressive behavior. Furthermore, the results suggest that an increase in the CEO’s ownership stake strengthens the negative association between the CEO’s religiosity and the extent of tax aggressive behavior. Finally, the CEO’s involvement in Zakat payments is shown to mitigate the negative association between the CEO’s religiosity and the extent of tax aggressive behavior.

Originality/value
In contrast to prior research that examines the relationship between religiosity and tax aggressiveness within the context of other religions, particularly Christianity, in listed firms, and primarily considers the religiosity of the overall firm environment, the study centers on the CEO’s religiosity in private Islamic family firms. The Islamic context further enables us to investigate whether the fulfillment of Zakat diminishes the moral obligation experienced by religious CEOs to fulfill their tax responsibilities.
On the effect of military spending on education in Africa: what role does institutional quality play?
Authors: Raifu Isiaka Akande , Uzoma-Nwosu Damian Chidozie , Aminu Alarudeen 
Published: August 2024

PurposeThis study explored how institutional quality influences the relationship between military spending and education in Africa.Design/methodology/approachThis study used data from 43 African countries spanning the years 2000–2021. Two estimation methods were employed to address various issues: Fixed Effects with Driscoll-Kraay standard errors and the Two-Step System Generalised Method of Moments. The Fixed Effects with Driscoll-Kraay standard error method was used to obtain reliable standard errors and inferences from the estimated coefficients of the fixed effects model. Meanwhile, the problem of endogeneity between military spending and education was addressed using the Two-Step System Generalized Method of Moments (GMM).FindingsThe results indicated that military spending negatively impacts both the quality and quantity of education. However, both institutional quality and the interaction term (institutional quality*military spending) have positive effects on both measures of education, suggesting that better institutional quality mitigates the negative effect of military spending on education outcomes.Practical implicationsThis study shows that institutional quality dampens the negative effect of military spending on education, especially the quality of education. Hence, African countries should prioritize strengthening their institutions to ensure optimal allocation and utilization of government funds for the benefit of their citizens.Originality/valueThis is the first study to examine the moderating role of institutional quality in the relationship between military spending and education, focusing on both the quantity and quality of education.
Corporate criminal liability and the identification principle: a critical and comparative analysis across Mauritius, US, UK and Canada
Authors: Beebeejaun Ambareen , Mandarun Raahil 
Published: August 2024

Purpose
The identification principle serves as a key tool in holding companies criminally accountable for acts of its agents, with the aim to secure convictions and promote a shift in corporate behaviour. Unfortunately, in Mauritius, the law is still not clear on how to engage the corporate criminal liability of the company although courts have attempted to apply the identification doctrine in some instances. Consequently, several corporate bodies are left unpunished for their criminal acts. Hence, the purpose of this paper is to evaluate the identification principle's applicability to corporate crimes in Mauritius.

Design/methodology/approach
To achieve the research objective, the black letter research method was adopted to collect secondary data by analysing the related laws on corporate criminal liability and a comparative analysis with some other countries’ rules on the subject matter was conducted. A desk-based approach and content analysis was used to collect this information. The countries selected for the comparison are the USA, UK and Canada.

Findings
From the critical analysis conducted in this paper, it is imperative for Mauritius to establish a more robust corporate criminal liability framework. The identified deficiencies, notably in Section 44(1)(a) of the Interpretation and General Clauses Act, should be reviewed and replaced with comprehensive norms with the goal of ensuring that corporate crimes are tackled properly. Such a proactive strategy not only empowers authorities to effectively address corporate crimes but also encourages corporate entities to take a proactive approach through the implementation of comprehensive compliance frameworks that are reviewed and updated on a regular basis.

Originality/value
At present, this study is among the few academic writings on corporate criminal liability in the context of Mauritius and it is being carried out with the aim of combining a large amount of empirical, theoretical and factual information that can be of use to various stakeholders and not only to academics.
Multidimensional frontline management styles: testing HRM strength, workgroup loyalty and helping behaviours
Authors: Cafferkey Kenneth , Townsend Keith , Riaz Safa , Bolt Ester Ellen Trees , Islam Md Shamirul 
Published: August 2024

PurposeThis study aims to investigate the relationships between various frontline management (FLM) styles, human resource management system (HRM) system strength and employees' helping behaviours as a form of organisational citizenship behaviours (OCBs). The research also examines the moderating role of workgroup loyalty in the association between HRM system strength and employees' helping behaviours.Design/methodology/approachThe research uses survey data collected from 315 government workers in Malaysia. Structural equation modelling (SEM) was employed to test the hypothesised relationships.FindingsTwo FLM styles, “policy enactor” and “employee coach,” positively predict employees' helping behaviour. However, the “organisational leader” FLM style did not significantly lead to employees' helping behaviour. HRM system strength significantly mediates the relationship between the three FLM styles and employee helping behaviours. Finally, workgroup loyalty significantly moderates the relationship between HRM system strength and employees’ helping behaviours as OCB.Practical implicationsWith a wealth of literature demonstrating the importance of FLMs in the implementation of HRM and a growing body of literature demonstrating the robust nature of the “system strength” argument, human resource (HR) practitioners are increasingly able to focus their attention on the way the system and FLMs contribute to employee outcomes and organisational performance. Our results indicate that HRM system strength does indeed enhance the impact of FLM styles on employee helping behaviours.Originality/valueThe originality of this paper is that it acknowledges and empirically examines the heterogenous nature of FLM styles, through signalling theory in enacting HRM policies and links the growing FLM literature to the HRM system strength research. These concepts have also been tested for the first time in a Malaysian context.
Hotel room pricing and economic benefit for local economies: evidence from Canada
Authors: Dubé Jean , Lapointe Anthony , Martel Vincent , Placide Mackens Brejnev , Torres Ospino Isabel Victoria 
Published: August 2024

Purpose
This paper aims to estimate the price premium for a sea view on room rent in a Nordic context, i.e. where proximity to the sea is not valued for the presence of swimmable beaches and suntanning activities. The analysis also explores regional and seasonal variations in price premiums.

Design/methodology/approach
To do so, the study uses information from a Web search of room rents during winter and summer peak seasons. The investigation is based on hotels located along the St. Lawrence River in the Province of Quebec (Canada), where about 40 to 60 km separate both shores. A matching procedure and hedonic pricing models are used to identify the causal impact of a sea view on individual room rents.

Findings
Results suggest that the view price premium varies between 0% and 20%. It is relatively stable on the North Shore, but varies highly on the South Shore, where touristic activities are mainly operating in summertime. The estimation suggests a median local economic benefit of about $30.1M/year.

Practical implications
The analysis reveals that a hedonic pricing model might fail to identify causal effects, especially if it does not account for hotel characteristics. A multiple linear regression model does not ensure a causal interpretation if it neglects unobserved characteristics correlated with the view.

Originality/value
The paper proposes a matching identification procedure accounting for spatial confounding to retrieve the causal impact of the view of the sea on hotel room rents. A heterogeneity analysis suggests that view price premium on room rent can vary within seasons but mainly across regions, even for the same amenities.