bluuebunny/crossref_metadata_2025_split huggingface dataset:
CNE Article: Moral Distress and Psychological Empowerment in Critical Care Nurses Caring for Adults at end of Life
Authors: Browning Annette M. 
Published: March 2013

BackgroundCritical care nurses providing care for adults at the end of life may encounter moral distress when they cannot do what they believe is ethically correct. Psychological empowerment can decrease moral distress among critical care nurses.ObjectivesTo describe the relationships between moral distress, psychological empowerment, and demographics in critical care nurses caring for patients at the end of life.MethodA total of 277 critical care nurses were surveyed via the Moral Distress Scale and the Psychological Empowerment Instrument. Responses were scored on a Likert scale of 1 to 7.ResultsMoral distress intensity was high (mean 5.34, SD 1.32) and positively correlated with age (r = 0.179, P = .01). Moral distress frequency was moderate (mean 2.51, SD 0.87) and negatively correlated with nurses’ collaboration in end-of-life patient care conferences (r = −0.191, P = .007). Psychological empowerment scores (mean 5.31, SD 1.00) were high and positively correlated with age (r = 0.139, P = .03), years of experience (r = 0.165, P = .01), collaboration in end-of-life-care conferences (r = 0.163, P = .01), and end-of-life-care education (r = 0.221, P = .001) and were negatively correlated with moral distress frequency (r = −0.194, P = .01). Multiple regression analysis revealed that empowerment was a significant predictor of moral distress frequency (â = .222, P &lt; .01).ConclusionThe significant negative correlation between psychological empowerment and frequency of moral distress in these nurses indicated that nurses with higher perceived empowerment experience moral distress less often. This finding is of particular interest as interventions to decrease moral distress are sought. (American Journal of Critical Care. 2013;22:143–152)
Constructing a modern cytology laboratory: A toolkit for planning and design
Authors: Roberson Janie , Wrenn Allison , Poole John , Jaeger Andrew , Eltoum Isam A. 
Published: March 2013

Introduction:
Constructing or renovating a laboratory can be both challenging and rewarding. UAB Cytology (UAB CY) recently undertook a project to relocate from a building constructed in 1928 to new space. UAB CY is part of an academic center that provides service to a large set of patients, support training of one cytotechnology program and one cytopathology fellowship training program and involve actively in research and scholarly activity. Our objectives were to provide a safe, aesthetically pleasing space and gain efficiencies through lean processes.

Methods:
The phases of any laboratory design project are Planning, Schematic Design (SD), Design Development (DD), Construction Documents (CD) and Construction. Lab personnel are most critical in the Planning phase. During this time stakeholders, relationships, budget, square footage and equipment were identified. Equipment lists, including what would be relocated, purchased new and projected for future growth ensure that utilities were matched to expected need. A chemical inventory was prepared and adequate storage space was planned. Regulatory and safety requirements were discussed. Tours and high level process flow diagrams helped architects and engineers understand the laboratory daily work. Future needs were addressed through a questionnaire which identified potential areas of growth and technological change. Throughout the project, decisions were driven by data from the planning phase. During the SD phase, objective information from the first phase was used by architects and planners to create a general floor plan. This was the basis of a series of meetings to brainstorm and suggest modifications. DD brings more detail to the plans with engineering, casework, equipment specifics, finishes. Design changes should be completed at this phase. The next phase, CD took the project from the lab purview into purely technical mode. Construction documents were used by the contractor for the bidding process and ultimately the Construction phase.

Results:
The project fitted out a total of 9,000 square feet; 4,000 laboratory and 5,000 office/support. Lab space includes areas for Prep, CT screening, sign out and Imaging. Adjacent space houses faculty offices and conferencing facilities. Transportation time was reduced (waste removal) by a Pneumatic Tube System, specimen drop window to Prep Lab and a pass thru window to the screening area. Open screening and prep areas allow visual management control. Efficiencies were gained by ergonomically placing CT Manual and Imaging microscopes and computers in close proximity, also facilitating a paperless workflow for additional savings. Logistically, closer proximity to Surgical Pathology maximized the natural synergies between the areas.

Conclusions:
Lab construction should be a systematic process based on sound principles for safety, high quality testing, and finance. Our detailed planning and design process can be a model for others undertaking similar projects
Feasibility of a Parenting Program to Prevent Substance Use among Latino Youth: A Community-Based Participatory Research Study
Authors: Allen Michele L. , Hurtado Ghaffar A. , Yon Kyu Jin , Okuyemi Kola S. , Davey Cynthia S. , Marczak Mary S. , Stoppa Patricia , Svetaz Veronica M. 
Published: March 2013

Purpose. Family-skills training programs prevent adolescent substance use, but few exist for immigrant Latino families. This study assesses the feasibility of a family-skills training intervention developed using a community-based participatory research framework, and explores parental traditional values as a modifier of preliminary effects. Design. One-group pretest-posttest. Setting. Four Latino youth–serving sites (school, clinic, church, social-service agency). Subjects. Immigrant Latino parents of adolescents aged 10 to 14 years (N = 83). Intervention. Eight-session program in Spanish to improve parenting practices and parent-youth interpersonal relations designed with Latino parents and staff from collaborating organizations. Measures. Feasibility was assessed through retention, program appropriateness, and group interaction quality. Preliminary outcomes evaluated were (1) parenting self-efficacy, discipline, harsh parenting, monitoring, conflict, attachment, acceptance, and involvement, and (2) parent perception of adolescent internalizing, externalizing, and substance use behaviors. Covariates included sociodemographics and parental endorsement of traditional values. Analysis. Feasibility outcomes were assessed with descriptive statistics. Paired t-tests measured changes in parenting outcomes. Adjusted multiple regression models were conducted for change in each outcome, and t-tests compared mean changes in outcomes between parents with high and low traditional values scores. Results. Program appropriateness and group interaction scores were positive. Improvement was noted for eight parenting outcomes. Parents perceived that adolescent internalizing behaviors decreased. Parents with lower endorsement of traditional values showed greater pretest-posttest change in attachment, acceptance, and involvement. Conclusion. This intervention is feasible and may influence parenting contributors to adolescent substance use.
Comparison of Enrollment Rates of African-American Families into a School-Based Tobacco Prevention Trial Using Two Recruitment Strategies in Urban and Rural Settings
Authors: Tingen Martha S. , Andrews Jeannette O. , Heath Janie , Turnmire Ashley E. , Waller Jennifer L. , Treiber Frank A. 
Published: March 2013

Purpose. This study evaluated similarities and differences of enrollment rates using two different recruitment strategies for a tobacco control trial in rural and urban African-American (AA) elementary school families. Design. A comparative study, nested within a larger randomized controlled trial, was used to test the effectiveness of two recruitment approaches on enrollment rates in rural and urban AA families. Setting. The study was conducted in 14 Title 1 elementary schools in the southeastern United States: 7 rural and 7 urban. Subjects. There were 736 eligible AA families, and 332 (45%) completed informed consent and were enrolled into the study. Intervention. The Facilitate, Open and transparent communication, Shared benefits, Team and tailored, Educate bilaterally, and Relationships, realistic and rewards (FOSTER) approach guided the two recruitment strategies: (1) written informational packets provided to fourth graders to take home to parents; and (2) proactive, face-to-face family information sessions held at schools. Measures. Enrollment rates were based on responsiveness to the two recruitment strategies and completion of the informed consent process. Analysis. Chi-square, Cochran-Mantel-Haenszel, and Breslow-Day tests were performed. Results. Higher enrollment rates occurred during the family session for both rural and urban families (100% rural, 93.6% urban; p = .0475) than informational packets alone (28.7% rural, 22% urban; p < .0001). Rural family enrollment rates were overall higher than urban rates regardless of recruitment strategy (52.0% rural vs. 39.6% urban; p = .0008). Conclusion. The findings suggest the FOSTER approach, although effective in both rural and urban settings, was more successful in recruiting rural families.
$LT^2C^2$ : A language of thought with Turing-computable Kolmogorov complexity
Authors: Romano Sergio , Sigman Mariano , Figueira Santiago 
Published: March 2013

In this paper, we present a theoretical effort to connect the theory of program size to psychology by implementing a concrete language of thought with Turing-computable Kolmogorov complexity ($LT^2C^2$ ) satisfying the following requirements: 1) to be simple enough so that the complexity of any given finite binary sequence can be computed, 2) to be based on tangible operations of human reasoning (printing, repeating,. . . ), 3) to be sufficiently powerful to generate all possible sequences but not too powerful as to identify regularities which would be invisible to humans. We first formalize $LT^2C^2$ , giving its syntax and semantics, and defining an adequate notion of program size. Our setting leads to a Kolmogorov complexity function relative to $LT^2C^2$ which is computable in polynomial time, and it also induces a prediction algorithm in the spirit of Solomonoff’s inductive inference theory. We then prove the efficacy of this language by investigating regularities in strings produced by participants attempting to generate random strings. Participants had a profound understanding of randomness and hence avoided typical misconceptions such as exaggerating the number of alternations. We reasoned that remaining regularities would express the algorithmic nature of human thoughts, revealed in the form of specific patterns. Kolmogorov complexity relative to $LT^2C^2$ passed three expected tests examined here: 1) human sequences were less complex than control PRNG sequences, 2) human sequences were not stationary showing decreasing values of complexity resulting from fatigue 3) each individual showed traces of algorithmic stability since fitting of partial data was more effective to predict subsequent data than average fits. This work extends on previous efforts to combine notions of Kolmogorov complexity theory and algorithmic information theory to psychology, by explicitly proposing a language which may describe the patterns of human thoughts.Received: 12 December 2012, Accepted: 3 February 2013; Edited by: G. Mindlin; DOI: http://dx.doi.org/10.4279/PIP.050001Cite as: S Romano,	M Sigman,	S Figueira, Papers in Physics 5, 050001 (2013)
Bases, Stages and ‘Working your Way Up’: Young People's Talk about Non-Coital Practices and ‘Normal’ Sexual Trajectories
Authors: Lewis Ruth , Marston Cicely , Wellings Kaye 
Published: March 2013

While the symbolic importance of ‘losing your virginity’ has been described in many settings, meanings of non-coital sexual experiences, such as oral sex and hand-genital contact, are often missing from theorisation of sexual transitions. Drawing on data from a qualitative mixed methods study with young people aged 16-18 in England (the ‘sixteen18 project’), we explore normative expectations about non-coital sex and sexual trajectories. Our study demonstrates how gendered talk about a ‘normal order’ of non-coital sexual activities ‘leading to’ vaginal intercourse contributes to a heteronormative discourse shaping sexual narratives and experiences long before first vaginal intercourse. Pre-coital sexual experiences were accounted for in terms of providing an opportunity for young men to develop and demonstrate sexual skill, for young women to be prepared for penetration by a penis and to learn to enjoy partnered sexual encounters, and for both sexes to develop the emotional intimacy required for first vaginal intercourse in a relationship. Prior to ‘having sex’, young people's talk about, and experience of, non-coital sexual activities helps circulate ideas about what ‘proper’ sex is, which sexual practices are valued and why, which skills are required and by whom, and whose pleasure is prioritised. If sexual health programmes are to challenge gendered inequalities in dominant assumptions about sex, non-coital sexual activities should be viewed as a legitimate area for discussion.
Preparation and characteristics of beta-glucan concentrate from brewer's yeast as the additive substance in foods
Authors: Kováčová Mária , Dodok Ladislav , Žofajová Livia , Mikuš Ľubomí­r 
Published: March 2013

The brewer¢s yeast was used for preparation of concentrate with content of β-glucan. Hot water extraction (100°C, 5 hours) and subsequently an alkaline extraction of sediment using 1 M NaOH at 90°C for 1 hour were used. β-glucan concentrate containing 59,15 % of β-glucan had good functional properties (water binding capacity 13,34 g water/1 g concentrate, fat binding capacity 6,86 g fat/1 g concentrate) and indicated biological action too. At concentration of 2 mg/ml DMSO (dimethylsulfoxid) was viability of murine L1210 leukemic cells reduced to 76.15 %. When observing the antioxidant activity it was identified, that the lipid peroxidation in linoleic acid samples was decreased during the presence of β-glucan concentrate. These results and good sensory properties like a bright colour and the pleasant taste and smell indicate, that prepared β-glucan concentrate has a potential to be used to improve the health – beneficial substances in the foods.
Perception of basic tastes and threshold sensitivity during testing of selected judges
Authors: Barborová Petra , Jančovičová Jana , Zajác Peter , Čapla Jozef , Vietoris Vladimí­r 
Published: March 2013

The sense of taste is one of the most important human senses. Alteration in taste perception can greately interfere to our lives, because it influences our dietary habits and consequently general human health. Many physiological and external factors can cause the loss of taste perception. These factors include for example certain diseases, the side effect of the use of certain medicaments, head trauma, gender, dietary habbits, smoking, role of saliva, age, stress and many more. In this paper we are discussing perception of basic tastes and treshold sensitivity during testing of selected groupe of 500 sensory judges. A resolution taste test and sensitivity treshold test were performed using basic tastes (sour, bitter, salty, sweet, umami, astringent, metallic). We have found that the perception of basic tastes decreese with human age. Smoking leads to significant errors in the determination of basic tastes. Different mistakes occures in different age categories. This study suggests further researches, investigating various factors influencing taste perception.
Hop pellets as an interesting source of antioxidant active compounds
Authors: Holubková Andrea , Mošovská Silvia , Baloghová Barbora , Šturdí­k Ernest 
Published: March 2013

Hop is a plant used by humankind for thousands of years. This plant is one of the main and indispensable raw materials for the beer production. It is used for various dishes preparation in the cuisine. Hop is also used to inhibit bacterial contamination. The hop extracts are used for its sedative, antiseptic and antioxidant properties in medicine, as a part of many phytopharmaceuticals. The present paper have focused on the extraction of polyphenolic compounds from 4 samples of hop pellets varieties of Aurora, Saaz, Lublin and Saphir, on the analyzing of bioactive substances (polyphenolics and flavonoids) in prepared extracts and on the determination of antioxidant activity. The highest content of polyphenolic substances was determined in the sample Lublin (153.06 mg gallic acid (GAE)/g) and Saaz (151.87 mg GAE/g). The amount of flavonoids in the samples was descending order Saaz > Saphir > Aurora > Lublin. Hops, as plant, is known by high content of antioxidant active substances. Antioxidant activity was determined using three independent spectrofotometric methods, radical scavenging assays using 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and ferric reducing antioxidant power (FRAP). The sample Aurora showed the highest ability to scavenge of ABTS radical cation. Antioxidant activity continued to decline in a row Saphir> Lublin> Saaz. The same trend was also observed by using the FRAP assay. The most effective DPPH radical scavengering activity had the sample Saaz a Saphir (p>0.05).
Making the Diagnosis of Frontotemporal Lobar Degeneration
Authors: Bigio Eileen H. 
Published: March 2013

Context.—Autopsy evaluation of the brain of a patient with frontotemporal dementia (FTD) can be daunting to the general pathologist. At some point in their training, most pathologists learn about Pick disease, and can recognize Pick bodies, the morphologic hallmark of Pick disease. Pick disease is a type of frontotemporal lobar degeneration (FTLD), the general category of pathologic process underlying most cases of FTD. The 2 major categories of pathologic FTLD are tauopathies (FTLD-tau) and ubiquitinopathies (FTLD-U). Pick disease is one of the FTLD-tau subtypes and is termed FTLD-tau (PiD).Objective.—To “demystify” FTLDs, and to demonstrate that subtypes of FTLD-tau and FTLD-U can be easily determined by following a logical, stepwise, histochemical, and immunohistochemical investigation of the FTD autopsy brain.Data Sources.—Previously published peer-reviewed articles.Conclusions.—The hope is that this article will be a useful reference for the general pathologist faced with performing a brain autopsy on a decedent with frontotemporal dementia.
Primary Adenocarcinoma of the Urinary Bladder: Differential Diagnosis and Clinical Relevance
Authors: Zhong Minghao , Gersbach Elizabeth , Rohan Stephen M. , Yang Ximing J. 
Published: March 2013

Context.—Glandular lesions of the urinary bladder include a broad spectrum of entities ranging from completely benign glandular lesions to primary and secondary malignancies. Common benign bladder lesions that exhibit glandular differentiation include cystitis cystica, cystitis glandularis, von Brunn nests, nephrogenic adenoma, intestinal metaplasia, urachal remnant, endometriosis, and prostatic-type polyp. The World Health Organization defines primary adenocarcinoma of the bladder as an epithelial malignancy with pure glandular differentiation without evidence of typical urothelial carcinoma. Malignant lesions that should be included in the differential diagnosis of a primary adenocarcinoma of the bladder include noninvasive and invasive urothelial carcinoma with glandular differentiation and secondary malignancies involving the bladder by direct extension or metastasis. The recognition and distinction of these different entities may be a challenge for pathologists, but they are of great clinical importance.
Objective.—To review features of primary bladder adenocarcinoma as well as those entities that need to be differentiated from primary bladder adenocarcinoma, with emphasis on clinical findings, pathologic characteristics, and immunoprofiles.
Data Sources.—Selected original articles published in the PubMed service of the US National Library of Medicine.
Conclusions.—The accurate diagnosis of adenocarcinoma of the urinary bladder is important and challenging. It has to prompt an extensive clinical workup to rule out other glandular lesions in the urinary bladder, especially the possibility of secondary involvement of the bladder by an adenocarcinoma from a different site.
Risk Evaluation and Mitigation Strategies: A Focus on Belatacept
Authors: Sam Teena , Gabardi Steven , Tichy Eric M. 
Published: March 2013

Objective To review the elements and components of the risk evaluation and mitigation strategies (REMS) for the costimulation blocker belatacept and associated implications for health care providers working with transplant recipients. Data Sources and Extraction The MEDLINE and EMBASE databases (January 1990 to March 2012) were searched by using risk evaluation and mitigation strategies, REMS, belatacept, and organ transplant as search terms (individual organs were also searched). Retrieved articles were supplemented with analysis of information obtained from the Federal Register, the Food and Drug Administration, and the manufacturer of belatacept. Data Synthesis REMS are risk-management strategies implemented to ensure that a product's benefits outweigh its known safety risks. Although belatacept offers a novel strategy in maintenance immunosuppression and was associated with superior renal function compared with cyclosporine in phase 2 and 3 trials, belatacept is also associated with increased risk of posttransplant lymphoproliferative disorder and central nervous system infections. The Food and Drug Administration required development of a REMS program as part of belatacept's approval process to ensure safe and appropriate use of the medication and optimization of its risk-benefit profile. Conclusion—Elements of the belatacept REMS include a medication guide that must be dispensed with each infusion and a communication plan. In the management of a complex population of patients, it is essential that those who care for transplant recipients, and patients, recognize the implications of potential and known risks of belatacept. The REMS program aims to facilitate careful selection and education of patients and vigilant monitoring.