bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the lymphoid tumor microenvironment (TILs) in breast cancer by flow cytometry
Authors: Zabotina T. N. , Borunova A. A. , Сhertkova A. I. , Shoua I. B. , Kadagidze Z. G. 
Published: July 2024

Despite the success in early diagnosis and drug treatment of breast cancer patients, long-term treatment results are still unsatisfactory, and in this regard, the role of research aimed at studying various mechanisms of development of this disease is increasing. It has been established that the degree of tumor infiltration by immune cells and their composition are directly related to the development of the disease and the response to therapy. Multiparameter flow cytometry (PC) allows studies of the subpopulation composition of TILs. The aim of the work was to study the features of the lymphoid microenvironment (TILs) of tumors in patients with primary operable and locally advanced breast cancer by PC. The study included patients with primary operable breast cancer (group 1, n = 121) and locally advanced (group 2, n = 80) receiving treatment at the N. N. Blokhin NMRCO. The TILs of a tumor obtained intraoperatively or by a core-biopsy were examined. The patients were divided into 3 subgroups: 1 subgroup – the degree of infiltration up to 1%, 2 subgroup – the degree of infiltration from 1 to 10%, and 3 subgroup – the degree of infiltration over 10%. Patients of group 1 were characterized by high functional activity and concentration of effector cells with a low degree of tumor infiltration, and as the number of lymphocytes in the tumor increased, an increase in the pool of CD4+ cells and CD4 Treg was noted simultaneously with a decrease in the number and functional activity of effector TILs. In group 2 were no significant differences in the cellular composition of TILs in subgroups with a weak and moderate degree of infiltration, and a variant with infiltration of more than 10% was recorded in only one patient. The lack of association of the TILs subpopulation structure in subgroups with varying degrees of tumor infiltration indicates a similar nature of the local immune response in locally advanced breast cancer.Thus, unlike patients with locally advanced breast cancer, patients with primary operable breast cancer show a change in the type of local immune response from effector to regulatory. A high degree of tumor infiltration is characterized by depletion of effector cell function.
A CHARACTERIZATION OF MEIXNER ORTHOGONAL POLYNOMIALS VIA A CERTAIN TRANSFERT OPERATOR
Authors: Abassi Emna , Khériji Lotfi 
Published: July 2024

Here we consider a certain transfert operator \(\mathrm{M}_{(c,\omega)}=I_{\mathcal{P}}-c \, \tau_{\omega},\) \(\omega\neq0,\) \({c \in \mathbb{R}-\{0,1\},}\) and we prove the following statement: up to an affine transformation, the only orthogonal sequence that remains orthogonal after application of this transfert operator is the Meixner polynomials of the first kind.
DILEMAS DO TRABALHO DOCENTE ORIUNDOS DAS TENSÕES DA EDUCAÇÃO PÚBLICA NO PROJETO CAPITALISTA DE DESENVOLVIMENTO
Authors: Matos Francilene do Rosário de , Melo Maria Alice 
Published: July 2024

Este artigo tem por objetivo contribuir com a compreensão dos fundamentos sócio-históricos de caráter político e econômico que constituem o trabalho docente na educação básica pública na contemporaneidade. Para tanto, realizou-se uma pesquisa bibliográfica a partir do estudo de renomados pesquisadores da área, como: Theresa Adrião (2020, 2022); Miguel Arroyo (2013, 2014); Stephen Ball (2020); François Chesnais (1996); Newton Duarte (2010); Olinda Evangelista (2006, 2014); Luíz Carlos Freitas (2014, 2018); Gaudêncio Frigotto (2015); Álvaro Hypólito (2012); Dalila Oliveira (2017, 2019, 2020); Philippe Perrenoud (2000); Márcio Pochmann (2020); Eneida Shiroma (2016); Maurice Tardif (2014), dentre outros. Como resultado obteve-se a indicação de tensões e dilemas vivenciados pelos professores, decorrentes do processo de remodelagem do trabalho docente, oriundo das reformas educacionais determinadas pelo projeto capitalista de desenvolvimento. Destacaram-se as tensões entre o trabalho docente codificado e o não codificado; entre a complexidade do ato educativo e o pragmatismo empregado à atividade docente; entre o discurso de supervalorização e responsabilização ‘dos professores e as precárias condições de trabalho e; entre a modernização tecnológica do trabalho docente e a racionalização da educação.
PRINCIPAIS DESFECHOS DE SAÚDE FÍSICA E MENTAL RELACIONADOS À INTENÇÃO PARA A PRÁTICA DA ATIVIDADE FÍSICA EM AGENTES DE SEGURANÇA: UMA REVISÃO SISTEMÁTICA
Authors: Forcellini Monica Manganelli Coimbra , Reis Milena Ketzer Caliendo dos , Machado Jean Marlon , Silva Elaine Cristine da , Weber Fernanda Matos , Santos Poliana Piovezana dos , Azevedo Sabrina Fernandes de , Silva Rudney da 
Published: July 2024

O presente trabalho tem como objetivo analisar os principais desfechos de saúde física e mental relacionados à prática da atividade física em agentes de segurança, por meio da Teoria do Comportamento Planejado. O método utilizado, inicialmente, explorou a literatura, por meio de uma revisão sistemática, buscando identificar os principais estudos existentes envolvendo a atividade física e a Teoria do Comportamento Planejado em agentes de segurança. Por meio da estratégia PRISMA, foram selecionados artigos científicos, sem restrição de ano ou instituição de segurança a qual pertença e publicados nas bases de dados PubMed, Biblioteca Virtual da Saúde, SciELO, Scopus, Web of Science e PsycINFO, tendo como descritores Mesh e seus correlatos disponíveis na língua inglesa os termos “Teoria do Comportamento Planejado”, “Atividade Física” e “Policiais”. Na análise dos trabalhos verificou-se a existência de apenas quatro estudos que abordem a temática sendo que ao final concluiu-se que o entendimento da intenção dos agentes de segurança para a prática (ou não) da atividade física, irá auxiliar os órgãos de segurança, por meio de suas corporações e instituições, a traçarem metas e políticas públicas buscando estratégias que auxiliem no aumento da qualidade de vida e a diminuição do acometimento de doenças crônicas não transmissíveis – DCNT, sendo relevante que estudos futuros abordem esta temática.
The mental health of staff at violence against women organizations during the COVID-19 pandemic: Findings from a mixed-methods study of service providers in Canada’s largest city
Authors: Steele Bridget , Shastri Priya , Moses Catherine , Tremblay Elizabeth , Arcenal Monique , O’Campo Patricia , Mason Robin , Du Mont Janice , Hujbregts Maria , Sim Amanda , Yakubovich Alexa R. 
Published: July 2024

Abstract
Objectives
Staff at violence against women (VAW) organizations provide essential services for survivors of violence. The increase in VAW during the COVID-19 pandemic placed additional pressures on VAW staff. We investigated the impacts of the pandemic on the mental health of VAW staff in the Greater Toronto Area to inform recommendations for policy and practice.

Methods
We conducted a community-based, mixed-methods study on the processes, experiences, and outcomes of adapting VAW programming during the pandemic using a sequential explanatory approach. Throughout 2021, we conducted a survey of direct support and leadership staff who worked on VAW services (“VAW staff”) followed by semi-structured interviews with VAW staff purposively sampled from the survey. We descriptively analyzed quantitative survey data on the mental health of 127 VAW staff. We then applied thematic analysis to qualitative data from 18 interviews with VAW staff. We used the qualitative data to support interpretation and enrich the quantitative findings regarding staff mental health.

Results
In the survey, 81% of leadership and 61% of direct support staff indicated that their work was more distressing during the pandemic. Participants reported moderate symptoms of vicarious trauma and mild symptoms of anxiety and depression. We generated three themes from the qualitative data to help explain these findings: (1) challenges related to changing work environments; (2) distress over not meeting client needs; and (3) difficulties in adapting self-care strategies in response to pandemic stressors.

Conclusion
VAW organizations require increased resources and flexible funding to hire and retain more staff to respond to higher and more complex caseloads during public health emergencies. With more structural supports in place, VAW organizations could create more time and space to develop their trauma-informed organizational practices: for example, establishing a culture of connection and learning among staff virtually and in-person and facilitating a range of self-care opportunities.
Representación social del habitante en situación de calle
Authors: Navarro Carrascal Oscar , Tamayo William 
Published: July 2024

Las representaciones sociales (RS) son formaciones cognitivas compartidas por un mismo grupo social. Las RS se definen por el sistema de interpretación que proporciona a un grupo de individuos un referente común. Este trabajo identifica las RS que tienen los Habitantes en Situación de Calle (HSC) de la ciudad de Medellín (Colombia) y los funcionarios de la administración municipal que trabajan con esta población. Para esta investigación exploratoria se realizaron 10 entrevistas a Habitantes en Situación de Calle (HSC) y a 10 operadores del Sistema de Atención al Habitante de Calle de la ciudad de Medellín. Se concluye que no hay una RS unificada dentro del grupo investigado de implicados en el Sistema de Atención al HSC. Sin embargo es posible reconocer un acuerdo en el proceso socio-cognitivo que elabora las representaciones sociales del HSC y determina los juicios y acciones respecto al objeto de representación.
The impact of laryngoscopy and tracheal intubation on thyroid gland
Authors: Dias Anusha Leah , Gomes Fraser 
Published: July 2024

Stress, fear, and emotions can induce variations in thyroid and growth factor hormone levels. For many patients, surgery is a significant source of stress, and because thyroid hormone release is influenced by stress, general anaesthesia and endotracheal intubation can raise Thyroid Hormone-blood concentrations. Therefore, this study was carried up to know the impact of laryngoscopy and intubation on TSH and free T4 blood levels in ASA 1 patients. : Following approval from the Ethics Committee and informed agreement from the participants, an observational descriptive cross-sectional study was undertaken at the department of anaesthesiology on 30 patients scheduled for elective surgery under general anesthesia. Blood samples were taken in EDTA tubes and tested for Free T4 and TSH levels within 3 hours of collection. A preformatted datasheet was used to document a thorough history, examination results, and laboratory investigations.Among the study participants out of 30, majority 22(73.3%) were males and remaining 8 (26.7%) were females and the mean age ranged from 17 years to 63 years. Various surgeries included laparoscopic and laparotomy, orthopaedic and urological surgeries. TSH mean levels did not differ among the three sampling sessions. The principal finding in our study was the increase in free T4 level immediately after intubation. Out of the 30 patients, 20 patients showed an increase in free T4 levels immediately after intubation and 8 patients continued to show an increase 20 minutes following intubation. Results showed increase in free T4 level immediately after intubation with no change in TSH levels. More research is required to conclude the cause for rise in thyroid hormones after anesthesia. These hormonal alterations could shed light on the molecular and cellular effects of anesthetics.
OPTIMIZING SCAFFOLDING TO IMPROVE STUDENTS' WRITING ANALYTICAL EXPOSITION IN AN EFL CLASSROOM CONTEXT [MENGOPTIMALKAN SCAFFOLDING UNTUK MENINGKATKAN KEMAMPUAN MENULIS EKSPOSISI ANALITIS SISWA DALAM KONTEKS KELAS EFL]
Authors: Nurlatifah Lala , Yusuf Fazri Nur 
Published: July 2024

<p><strong>Abstract </strong></p><p>The preliminary study of the present research showed that students faced problems in writing English analytical exposition text. Framed in classroom action research, this study aims to investigate how using scaffolding as a strategy in teaching writing can improve students' writing in analytical exposition text. This qualitative study employed document analysis and interviews to answer the research questions. The participants of this study were 26 EFL students in a senior high school in Bandung, and six students participated in interview sessions. The result indicated that the scaffolding process implemented in two action research cycles improved students' skills in writing analytical exposition text in all aspects of writing: content, organization, grammar, vocabulary, and mechanics. Besides, students also showed a positive perception toward implementing scaffolding through various activities in the classroom. This study recommends that scaffolding writing be applied using multiple online tools in more diverse educational settings since the rapid progress of information technology enables learners to acquire knowledge and improve skills online. </p><p> </p><p><strong>Bahasa Indonesia Abstrak </strong></p><p>Studi pendahuluan dari penelitian ini menunjukkan bahwa siswa menghadapi masalah dalam menulis teks eksposisi analitis menggunakan bahasa Inggris. Dibingkai dalam penelitian tindakan kelas, penelitian ini bertujuan untuk menyelidiki bagaimana penggunaan <em>scaffolding</em> sebagai strategi dalam pengajaran menulis dapat meningkatkan kemampuan menulis siswa dalam teks eksposisi analitis. Penelitian kualitatif ini menggunakan analisis dokumen dan wawancara untuk menjawab pertanyaan penelitian. Partisipan dari penelitian ini adalah 26 siswa EFL di sebuah sekolah menengah atas di Bandung, dan enam siswa berpartisipasi dalam sesi wawancara. Hasil penelitian menunjukkan bahwa proses <em>scaffolding</em> yang diterapkan dalam dua siklus penelitian tindakan meningkatkan kemampuan siswa dalam menulis teks eksposisi analitis di semua aspek penulisan: konten, organisasi, tata bahasa, kosakata, dan mekanik. Selain itu, siswa juga menunjukkan persepsi yang positif terhadap penerapan <em>scaffolding</em> melalui berbagai kegiatan di kelas. Penelitian ini merekomendasikan agar penulisan scaffolding dapat diterapkan dengan menggunakan berbagai alat <em>online</em> dalam lingkungan pendidikan yang beragam karena kemajuan teknologi informasi yang pesat memungkinkan siswa untuk memperoleh pengetahuan dan meningkatkan keterampilan <em>online</em>.</p>
PENGARUH KOLABORASI DOSEN, KEMAMPUAN TEKNIS DOSEN, DAN PARTISIPASI DARING DOSEN TERHADAP KEPUASAN MAHASISWA PADA PROGRAM PENDIDIKAN JARAK JAUH DI UNIVERSITAS XYZ [THE INFLUENCE OF LECTURER COLLABORATION, LECTURER TECHNICAL ABILITY, AND LECTURER ONLINE PARTICIPATION ON STUDENT SATISFACTION IN DISTANCE EDUCATION PROGRAMS AT XYZ UNIVERSITY]
Authors: Bawono Masatyo , Yugopuspito Pujianto 
Published: July 2024

<p><strong>Abstract</strong></p><p>Student satisfaction is one of the factors that influence student motivation and learning process. The more satisfied students are, the higher their motivation to complete their studies and have a better learning process. This study aims to see the effect of lecturers' collaboration level, lecturers' technical ability, and lecturers' online participation in the online classroom on student satisfaction. The research was conducted on active students of the Communication Science Distance Education study program in 2018 with a total of 88 respondents. Data were obtained through a survey consisting of 40 questions. The data were processed with the PLS method using SmartPLS software. The results obtained are lecturer collaboration, lecturer technical ability, and lecturer online participation in online classrooms have a positive effect on student satisfaction, with lecturer technical ability being the most influential factor on student satisfaction. Mastery of technology and the use of various methods of lecturer participation in online classrooms are recommended approaches for lecturers to take.</p><p> </p><p><strong>Bahasa Indonesia Abstrak</strong></p><p>Kepuasan Mahasiswa merupakan salah satu faktor yang mempengaruhi motivasi dan proses belajar siswa. Semakin puas siswa, maka motivasi mereka semakin tinggi untuk menyelesaikan studi dan memiliki proses belajar yang lebih baik. Penelitian ini bertujuan untuk melihat pengaruh dari tingkat Kolaborasi Dosen, Kemampuan Teknis Dosen, dan Partisipasi Daring Dosen pada online classroom terhadap Kepuasan Mahasiswa. Penelitian dilakukan pada mahasiswa aktif program studi Pendidikan Jarak Jauh Ilmu Komunikasi di tahun 2018 dengan total responden sebanyak 88 orang. Data diperoleh melalui survey yang terdiri dari 40 pertanyaan. Data diolah dengan metode PLS menggunakan perangkat lunak SmartPLS. Hasil yang diperoleh adalah Kolaborasi Dosen, Kemampuan Teknis Dosen, dan Partisipasi Daring Dosen pada ruang kelas daring berpengaruh positif terhadap Kepuasan Mahasiswa, dengan Kemampuan Teknis Dosen yang menjadi faktor paling berpengaruh terhadap kepuasan siswa. Penelitian ini terbatas pada satu program studi saja, dan terbatas pada siswa yang aktif di tahun 2018.</p><p> </p>
Em tempo/espaço pandêmico
Authors: Souza Soraya , Archangelo Ana , Mendonça Lilian Cardozo de 
Published: July 2024

Este trabalho constata que o retorno à presencialidade da Educação no nosso tempo/espaço (pós-)pandêmico gerou novas formas de sofrimento e da constituição psíquica dos alunos. As (re)formulações existenciais no novo normal causaram surpresas e impasses: para muitas crianças, a Escola é apenas lugar de abrigo e manutenção dos laços sociais, não mais de relação com o conhecimento formal. Qual a função da Escola em tempo/espaço pandêmico? Como torná-la significativa? Esta discussão esteve presente em rodas de conversa remotas, semanais, com professores de ensino fundamental I e II, em uma escola pública do estado de São Paulo. Procurou-se (re)significar tempos de perdas, espaços invadidos e configurar o novo “normal” na escola, considerando diversas fontes de sofrimento docente: a identificação com as crianças, privadas do direito de exercer a infância, brincar, jogar, abraçar e beijar; o silenciamento do luto, impedido de adentrar o contexto escolar; plataformas digitais em repentina operação; grupos de WhatsApp gerenciados escamoteavam o acesso desigual à tecnologia. Os professores viveram impasses, medos e terror. O não saber, o não desejar saber e a desigualdade apagaram-se com a pandemia, e a Escola retomou atividades presenciais de ensino e avaliação, como se a experiência individual e coletiva não tivesse sido interrompida. Nos professores, o sentimento de solidão: como justificar para a sociedade e para si próprios, a (des)função da Escola?
Maternal-related factors associated with development and improvement of peripartum cardiomyopathy and therapeutic outcomes of bromocriptine
Authors: Pradnyaandara I Gusti Bagus Mulia Agung , Mulyana Ryan Saktika , Sutedja Jane Carissa , Jagannatha Gusti Ngurah Prana , Wibawa I Bagus Satriya , Deantri Fanny , Pradnyana I Wayan Agus Surya , De Liyis Bryan Gervais 
Published: July 2024

HIGHLIGHTS
Younger age, black race, normotension, and multiparity indicate a poorer prognosis for peripartum cardiomyopathy recovery, while bromocriptine therapy reduces adverse events.

ABSTRACT
Objectives: This study aimed to fill the significant knowledge gap regarding peripartum cardiomyopathy (PPCM), a heart failure phenotype linked to pregnancy. The main objectives were to explore the factors influencing the development and progression of PPCM and to assess the outcomes of bromocriptine.Materials and Methods: Systematic search across PubMed, ScienceDirect, and Cochrane Library identified studies until December 2022. This study includes non-randomized prospective and retrospective studies, as well as relevant randomized controlled trials. Risk factors were compared between the recovered and non-recovered PPCM groups, and bromocriptine therapy outcomes were evaluated against standard heart failure treatment as the primary endpoint.Results: The analysis included 24 observational studies and 1 randomized controlled trial involving 1,651 PPCM patients; 9 studies evaluating the outcomes of bromocriptine therapy. The most prevalent factors were caesarean delivery (proportion=53%, 95%CI=41%-66%) and anemia (proportion=51%, 95%CI=38%-65%). Non-recovered patients were younger (MD=-1.04 years old, 95%CI=-1.82-(-0.27), p=0.008) and predominantly black (RR=1.82, 95%CI=1.43-2.31, p <0.001). Hypertensive disorders and primiparity were found less among non-recovered patients (RR=0.73, 95%CI=0.60-0.88, p=0.001; RR=0.81, 95%CI=0.66-0.99, p=0.04, respectively). Non-recovered patients also exhibited higher baseline serum creatinine levels, lower LVEF, larger left ventricular end-systolic diameter (LVESD), larger left ventricular end-diastolic diameter (LVEDD), and lower fractional shortening (all P-values<0.05). Furthermore, bromocriptine significantly reduced major adverse cardiac events (MACE), mortality, and increased LVEF (all P-values<0.05).Conclusion: Younger maternal age, black race, absence of hypertension, and multiparity are associated with poorer prognosis for PPCM recovery. Bromocriptine therapy demonstrates superior benefits in reducing adverse events in PPCM.
The prognostic role of mitosis index, stage and grade of endometrial cancer in Dr. Soetomo General Academic Hospital Surabaya, Indonesia, in 2018-2020
Authors: Umi Choviva Farida , Sandhika Willy , Mulawardhana Pungky 
Published: July 2024

HIGHLIGHTS
1. Mitotic index and grade are prognostic factors for endometrial cancer, but both are independent.2. Stage and mitotic index associated with cell proliferation affect the prognosis of endometrial cancer.

ABSTRACT
Objective: This study aimed to analyze the correlation between the mitotic index and the stage and grade of endometrial cancer.
Materials and Methods: We collected pathology reports of endometrial cancer from the Pathology Laboratory at Dr. Soetomo General Hospital in Surabaya, Indonesia, covering cases diagnosed between 2018 and 2020. A total of 106 cases of endometrial cancer were included in this study. For each case, detailed records of the cancer stage, grade, and mitotic index were recorded. The mitotic index, an indicator of cell proliferation, was quantified, and its correlation with cancer stage and grade was assessed. To determine the strength and direction of these relationships, we performed a Spearman rank correlation statistical analysis for non-parametric data.
Results: Our findings indicated a significant positive correlation between the mitotic index and the stage of endometrial cancer. An increase in the mitotic index, reflecting a higher proliferation rate of cancer cells, was associated with a more advanced cancer stage, suggesting that the mitotic index could potentially serve as a prognostic marker for assessing tumor progression in endometrial cancer. However, our analysis revealed no significant correlation between the mitotic index and the histological grade of endometrial cancer, implying that the grade, which typically reflects the differentiation status and morphological characteristics of the tumor cells, is independent of the proliferation rate as measured by the mitotic index.
Conclusion: The mitotic index is positively correlated with the stage of endometrial cancer but does not show a correlation with the histological grade. These findings highlight the potential use of the mitotic index in staging endometrial cancer.
WITHDRAWN: Chemerin and Sfrp5 levels in Subclinical Hypothyroid
Authors: Şerefli Köksal , Bilgici Birşen , Akcan Songül , Tomak Leman , Atmaca Ayşegül Akın 
Published: July 2024

Abstract

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.