bluuebunny/crossref_metadata_2025_split huggingface dataset:
Probable case of Cephalotheca foveolata bloodstream infection
Authors: Lu Lenette L. , Weil Ana A. , Wiederhold Nathan , Sutton Deanna A. , Chesnut Lauren , Lindner Jonathan , Fan Hongxin , Tingpej Bhatraphol , El-Khoury Joseph , Kwon Douglas S. 
Published: July 2015

Introduction:

Cephalotheca foveolata is a saprobic fungus recently described among clinical isolates.

Case presentation:
A 59-year-old man presented with fevers, upper back pain and shortness of breath after gastric tube removal following an oesophagectomy, oesophagojejunostomy and gastrostomy for management of oesophogeal adenocarcinoma. He had a suspected oesophageal leak and polymicrobial empyema. Blood cultures grew only C. foveolata. He improved clinically on empiric antifungal and broad-spectrum antibacterial therapy.

Conclusion:
We report a probable case of C. foveolata bloodstream infection. This is a newly recognized pathogen requiring molecular diagnostic methods to make an accurate diagnosis.
Endocarditis and myocardial abscess caused by group B Streptococcus
Authors: Bettenhausen Aaron , Sander Jared , Carson Paul , Koponen Mark , Dyke Cornelius 
Published: July 2015

Introduction:
Group B Streptococcus (GBS) is a rare infectious endocarditis. Patients with GBS infective endocarditis have a high rate of local and systemic complications.

Case presentation:
A 30-year-old male presented to the Emergency Department with fever, chills, fatigue and a recent onset of symptoms suggestive of stroke following a bout of pyelonephritis. Echocardiography confirmed a diagnosis of endocarditis and blood cultures grew GBS. Antibiotic therapy was initiated with penicillin G and gentamicin. Urological evaluation revealed a urethral stricture. He was taken to the operating room on hospital day 10 for the debridement of his aortic annulus, reconstruction of his aortic root and replacement of his aortic valve. On post-operative day 7, he died of sudden cardiac arrest. A large myocardial abscess located within the interventricular septum was identified post-mortem.

Conclusion:
Recurrent or complicated urinary tract infections are rare among the young male population. Without evaluation and treatment for the underlying pathology, patients are at risk of developing antimicrobial-resistant infections, which may disseminate rapidly. Although a common pathogen of the urinary tract, GBS is a rare infectious agent for endocarditis. We propose urethral stricture as a risk factor for developing GBS endocarditis. Operative timing for these infections can be challenging; however, urgent and radical surgical debridement appears to yield favourable results.
Native valve endocarditis caused by Streptococcus oligofermentans: a case report
Authors: Menon Thangam , Gopalakrishnan Sathyanarayanan , Ravi Marimuthu Shanmugam 
Published: July 2015

Introduction:
Viridans group streptococci (VGS), which are commensal flora in the oral cavity, can act as opportunistic pathogens causing serious infections such as infective endocarditis (IE). Species identification of these organisms is difficult because of variability in phenotypic traits among strains of the same species.

Case presentation:
We report a case of endocarditis in a 64-year-old male patient caused by Streptococcus oligofermentans, which was identified by 16S rRNA gene sequencing. S. oligofermentans is a commensal of the oral cavity and rarely causes disease. This is the second report of IE caused by S. oligofermentans.

Conclusion:
Molecular methods are necessary to ascertain the identity of VGS strains, particularly those that rarely cause human disease.
Streptococcus pneumoniae infection of the lumbar epidural spine: a rare condition with distinctive signs requiring specialized intervention
Authors: Carson Henry J. , Boyd Jonnine , Witt Frederick L. 
Published: July 2015

Introduction:
Bacterial infection of the vertebral column is uncommon, but when it occurs, the meninges are at high risk.

Case presentation:
A patient presented with acute-onset back pain and signs of inflammation, excluding an elevated white count and bacteraemia. Laminectomy specimens showed infection with Streptococcus pneumoniae. No previous source of possible seeding of the bacteria was identified.

Conclusion:
The infection responded to intravenous ceftriaxone. This case informs us to be aware of infection in a case of back pain even without a prior source of infection.
Staphylocccus intermedius group infections in humans: report of four cases and a literature review
Authors: Frank Maria G. , Keniston Angela , Madinger Nancy , Price Connie , Bessesen Mary T. 
Published: July 2015

Introduction:

Staphylococcus intermedius group (SIG) comprises coagulase-positive staphylococci isolated from veterinary wounds, with anecdotal association of this pathogen and disease in humans. To date, 28 human cases have been described in the literature. Here, we described four cases of human infection caused by SIG members and, through a literature review, identified potential common characteristics and risk factors for this infection.

Case presentations:
Cases were obtained via electronic query of existing microbiology records for S. intermedius isolates at three teaching hospitals in Denver, CO, USA, between 2003 and 2008. Four cases were identified. Three cases were soft tissue and/or bone infection and one case was a urinary tract infection.

Conclusion:

Staphylococcus intermedius infections in humans are rarely identified. Dog ownership as well as diabetes or other causes of immunosuppression may place patients at higher risk. Misidentifying SIG infections could lead to delays in treatment as well as undertreatment of this zoonosis.
TreeQTL: hierarchical error control for eQTL findings
Authors: Peterson Christine , Bogomolov Marina , Benjamini Yoav , Sabatti Chiara 
Published: July 2015

AbstractSummaryCommonly used multiplicity adjustments fail to control the error rate for reported findings in many expression quantitative trait loci (eQTL) studies. TreeQTL implements a stage-wise multiple testing procedure which allows control of appropriate error rates defined relative to a hierarchical grouping of the eQTL hypotheses.Availability and ImplementationThe R package TreeQTL is available for download athttp://bioinformatics.org/treeqtl.Contactsabatti@stanford.edu
Learning from heterogeneous data sources: an application in spatial proteomics
Authors: Breckels Lisa M. , Holden Sean , Wojnar David , Mulvey Claire M. , Christoforou Andy , Groen Arnoud , Trotter Matthew W.B. , Kohlbacher Oliver , Lilley Kathryn S. , Gatto Laurent 
Published: July 2015

AbstractSub-cellular localisation of proteins is an essential post-translational regulatory mechanism that can be assayed using high-throughput mass spectrometry (MS). These MS-based spatial proteomics experiments enable us to pinpoint the sub-cellular distribution of thousands of proteins in a specific system under controlled conditions. Recent advances in high-throughput MS methods have yielded a plethora of experimental spatial proteomics data for the cell biology community. Yet, there are many third-party data sources, such as immunofluorescence microscopy or protein annotations and sequences, which represent a rich and vast source of complementary information. We present a unique transfer learning classification framework that utilises a nearest-neighbour or support vector machine system, to integrate heterogeneous data sources to considerably improve on the quantity and quality of sub-cellular protein assignment. We demonstrate the utility of our algorithms through evaluation of five experimental datasets, from four different species in conjunction with four different auxiliary data sources to classify proteins to tens of sub-cellular compartments with high generalisation accuracy. We further apply the method to an experiment on pluripotent mouse embryonic stem cells to classify a set of previously unknown proteins, and validate our findings against a recent high resolution map of the mouse stem cell proteome. The methodology is distributed as part of the open-source BioconductorpRolocsuite for spatial proteomics data analysis.AbbreviationsLOPITLocalisation of Organelle Proteins by Isotope TaggingPCPProtein Correlation ProfilingMLMachine learningTLTransfer learningSVMSupport vector machinePCAPrincipal component analysisGOGene OntologyCCCellular compartmentiTRAQIsobaric tags for relative and absolute quantitationTMTTandem mass tagsMSMass spectrometry
Low but significant genetic differentiation underlies biologically meaningful phenotypic divergence in a large Atlantic salmon population
Authors: Aykanat Tutku , Johnston Susan E. , Orell Panu , Niemelä Eero , Erkinaro Jaakko , Primmer Craig R. 
Published: July 2015

AbstractDespite decades of research assessing the genetic structure of natural populations, the biological meaning of low yet significant genetic divergence often remains unclear due to a lack of associated phenotypic and ecological information. At the same time, structured populations with low genetic divergence and overlapping boundaries can potentially provide excellent models to study adaptation and reproductive isolation in cases where high resolution genetic markers and relevant phenotypic and life history information are available. Here, we combined SNP-based population inference with extensive phenotypic and life history data to identify potential biological mechanisms driving fine scale sub-population differentiation in Atlantic salmon (Salmo salar) from the Teno River, a major salmon river in Europe. Two sympatrically occurring sub-populations had low but significant genetic differentiation (FST= 0.018) and displayed marked differences in the distribution of life history strategies, including variation in juvenile growth rate, age at maturity and size within age classes. Large, late-maturing individuals were virtually absent from one of the two sub-populations and there were significant differences in juvenile growth rates and size-at-age after oceanic migration between individuals in the respective sub-populations. Our findings suggest that different evolutionary processes affect each sub-population and that hybridization and subsequent selection may maintain low genetic differentiation without hindering adaptive divergence.
Does competency matter? Competency as a factor in workplace bullying
Authors: McDaniel Karen Rogers , Ngala Florence , Leonard Karen Moustafa 
Published: July 2015

Purpose– The purpose of this paper is to explore the intersection of competency and bullying behaviors, not yet reported in the literature.Design/methodology/approach– The approach is an examination of the literature available on both topics, and development of a framework related to both.Findings– The theory is that there is a strong mediating relationship between the victim’s self-perception of competency and outcomes (the victim’s reactions) to bullying behaviors. There are multiple impacts of bullying behaviors, but the authors believe this mediation action of competency might be crucial. There is little research on competency or expertise in terms of behaviors resulting from these self-assessments. Future research should seek to examine the link empirically, and there are implications about the competency levels of bullies themselves that might arise.Research limitations/implications– As this is a newly developed research stream, the authors plan to continue with work on the topic.Practical implications– By developing competency, individuals may develop some protection or coping mechanisms when confronted by bullying behaviors. Managers need to be aware of the need to allow employee development to reduce the incidence of such behaviors.Social implications– Bullying behaviors have become rampant in society. In trying to determine where the problem might be best addressed, the authors feel that they have made a significant impact to allow managers to address competency among those victimized by these behaviors. This should have a flow-on effect for organizational and societal culture.Originality/value– This is an intersection that has not been explored but holds significant explanatory power in the area. These bullying behaviors are on the rise; therefore, it is an exceptional opportunity to present new ideas in a forum that is well read by both academics and practitioners.
Employee benefits and high-tech fatherhood
Authors: Blumen Orna 
Published: July 2015

Purpose– This study, inspired by the theory of the separate spheres, considers the social circumstances of employee benefits, examining the needs of fathers in dual-earner families to cope with work and family responsibilities. The purpose of this paper is to explore how high-tech managers view the work-family interface of R & D engineers and analyzes the typical package of discretionary, non-financial, work-family employee benefits.Design/methodology/approach– Relying on the phenomenological approach, in-depth, semi-structured interviews with 22 private-sector managers disclosed their shared perception and experience, revealing the informal level at which underlying social principles becomes business strategy, often intuitively.Findings– Values of gender are assimilated into the informal environment and reflected in the selection of benefits which have been effective in attracting labor in demand. Recently these values have been challenged by new ideas of more involved fatherhood, and these are inadequately addressed by the package of benefits.Research limitations/implications– Larger samples from various socio-cultural settings are needed.Practical implications– Managers are advised not to be blinded by the financial worth of discretionary employee benefits and consider how these meet the actual, as opposed to stereotypical, needs of employees and their family members. Observing social dynamics and considering non-financial consequences of employee benefits are essential for business-society continuity. Also, organizations of relatively low-social diversity should not alienate themselves from their multicultural environment.Social implications– The study unveils the reciprocity between organizations and people. Traditional fatherhood is being contested and negotiated at the work-family interface, as embedded to ongoing changes in the social meaning of gender. That employee benefits help to maintain the masculinity of high-tech, reflects also on gender segregation in the workplace.Originality/value– The study illustrates how businesses apply social values and describes how such values are processed and reinstated in society as employee benefits.
Online networking and employee engagement: what current leaders do?
Authors: Korzynski Pawel 
Published: July 2015

Purpose– The purpose of this paper is twofold: to examine the role of online networks in employee engagement and to analyze the factors influencing leaders’ involvement in online social networking.Design/methodology/approach– The study’s participants included team leaders, managers and directors working in Fortune 500 companies in the USA. Data were collected through structured surveys delivered through LinkedIn, professional online networking platform to randomly selected users with leadership roles. Totally, 194 matched questionnaires were returned.Findings– The results indicate that employee engagement is positively associated with the time leaders spend on internal online networking platforms, the code of online networking conduct, and the presence of an open-organizational culture. Furthermore, the study shows that organizations can influence leaders’ use of online social networking platforms through an open culture and training. Finally, the findings also indicate that leaders, who communicate with a higher percentages of employees through internal and external platforms, also spend more time on online social networking platforms than those who do not. Surprisingly, a hierarchical structure and the code of conduct are not an indicator of the number of hours that leaders spend on online networking platforms.Research limitations/implications– The study has three main limitations. First, it was conducted among leaders working in companies from the Fortune 500 list, because the majority of these companies have already implemented internal networking platforms, which are not yet popular in small and medium enterprises (SME). In the future, companies from the SME sector are also worth studying. Second, the study was undertaken among leaders from the USA, because most of the online networking platforms were developed there and then adopted in other countries. Online networking trends in other countries are also very interesting topics for study in future research projects. Third, the quality of the time leaders spend on online platforms should also be examined in future studies.Practical implications– The next generation of leaders should pay increasing attention to online social networking platforms so as to be more effective in fostering employees’ social and emotional well-being. Organizations that seek ways to facilitate involvement among their leaders in internal online networking, need to organize training and support leaders and employees in the use of online networking platforms.Social implications– The use of online social networking platforms change the way people communicate with others and how companies can use online social networking for the social well-being of their employees.Originality/value– This research provides a new look at employee engagement in the current working environment as well as organizational features fostering leaders’ involvement in online networking.
Technology and application of the LTCC-based microfluidic module for urea determination
Authors: Malecha Karol , Remiszewska Elżbieta , Pijanowska Dorota G 
Published: July 2015

Purpose
– The purpose of this paper is to focus on the technology and performance of the miniature microfluidic module for urea determination. The presented module was made using low-temperature co-fired ceramics (LTCC). It shows the possibility for the integration of the bioreceptor layers with structures that have been fabricated using modern microelectronic technology.

Design/methodology/approach
– The presented microfluidic module was fabricated using LTCC technology. The possibility for the fabrication of an enzymatic microreactor in a multilayer ceramic substrate, made of CeramTec glass ceramic (GC) material systems with an integrated thick-film heater, is studied. Different configurations of the LTCC/heater materials (gold, silvers and palladium-silver) are taken into account. The performance of the LTCC-based microfluidic module with the integrated heater and immobilized enzyme was examined experimentally.

Findings
– A compatible material for the heater embedded in the CeramTec GC-based structures was found. The preliminary measurements made for the test solution containing various concentrations of urea have shown stability (for seven days of operation) and a relatively high signal-to-noise ratio (above 3 pH units) for the microreactor’s output signal.

Research limitations/implications
– The presented research is a preliminary work which is focused on the fabrication of the LTCC-based microfluidic module, with an integrated heater and immobilized enzyme for urea determination. The device was positively tested using a model reaction of the hydrolysis of urea. However, urea concentration in real (biological) fluid should also be measured.

Practical implications
– The development of the LTCC-based microfluidic module for urea determination provides opportunity for the construction of a lab-on-chip, or μTAS-type system, for fast medical diagnoses and the continuous monitoring of various biochemical parameters, e.g. for estimating the effectiveness of hemodialysis.

Originality/value
– This paper shows the design, fabrication and performance of the novel microfluidic module for urea determination, made with LTCC technology.
Magnetoelectric properties in bulk and layered composites
Authors: Guzdek Piotr , Wzorek Marek 
Published: July 2015

Purpose
– The purpose of the paper was to present a comparative study on the microstructure and magnetoelectric effect of new magnetoelectric composites based on TbFe2 compound and Ni0.3Zn0.62Cu0.08Fe2O4, CoFe2O4 ferrites as a magnetostrictive phase, Pb(Fe1/2Ta1/2)O3 (PFT), Pb(Fe1/2Nb1/2)O3 relaxors as a ferroelectric phase and polyvinylidene fluoride (PVDF) as piezoelectric phase.

Design/methodology/approach
– The ceramic components of composites were prepared by the standard solid-state reaction method. The intermetallic compound TbFe2 was prepared with an arc melting system with a contact-less ignition in a high purity argon atmosphere. The metal – ceramic – polymer composites were prepared in a container in which powder of PVDF were dissolved in N,N-dimethylformamide with continuous mixing and at the controlled temperature. Ceramic composites were prepared as bulk samples and multilayer tape cast and co-sintered laminates. The microstructure of the composites was investigated using scanning electron microscopy (SEM). The magnetoelectric effect of the composites was evaluated at room temperature by means of the dynamic lock-in method.

Findings
– SEM analysis revealed a dense, fine-grained microstructure and uniform distribution of the metallic, ferrite and relaxor grains in the bulk composites. The SEM image for multilayer composite illustrates the lack of cracks or delaminations at the phase boundaries between the well-sintered ferrite and relaxor layers. For all studied composites, the magnetoelectric coefficients at a lower magnetic field increase, reaches a maximum and then decreases.

Originality/value
– The progress in electronic technology is directly linked to advances made in materials science. Exploring and characterizing new materials with interesting magnetoelectric properties, in the rapidly growing field of functional materials, is an important task. The paper reports on processing, microstructure and magnetoelectric properties of novel magnetoelectric composites.
Thermoelectric properties of thin-film germanium-based layers
Authors: Markowski Piotr , Prociów Eugeniusz , Urbaniak Łukasz 
Published: July 2015

Purpose
– The purpose of this paper is to determine the thermoelectric properties of the germanium-based thin films and selecting the most suitable ones for fabrication of micrognerators.

Design/methodology/approach
– The germanium layers were deposited by low pressure magnetron sputtering method, in the pressure of 10−3/104 mbar range. The amount of dopants (germanium or vanadium) was changed in a limited extent. The influence of such changes on the layers output properties was studied. Post-processing heat treatment at temperature below 823 K was applied to activate the layers. It leads to improve the electrical and thermoelectrical performance.

Findings
– The special attention was paid to the power factor (PF = S2/ρ) of the layers. To estimate power factor (PF) electrical resistivity (ρ) and Seebeck coefficient (S) were determined. The achieved Seebeck coefficient value was 185 Volt/Kelvin (μV/K) for germanium doped with vanadium (Ge:V1.15) and 225 μV/K for germanium doped with gold(Ge:Au3.13) layers at room temperature. After activation process, the PF reached a value of 2.5 × 10−4 W/m · K2 for the Ge:Au3.13 and 1.1 × 10−4 W/m · K2 for the Ge:V1.15 layers.

Originality/value
– The fabricated thermoelectric layers can be thermally annealed in temperature up to 823 K in the air and in 1,023 K under a nitrogen atmosphere. This enables integration of thin layers with thick-film technology. Corning glass or low temperature cofired ceramic was used as a substrate.