bluuebunny/crossref_metadata_2025_split huggingface dataset:
Programmed Cell Death 1 (PD-1) and Its Ligand (PD-L1) in Common Cancers and Their Correlation with Molecular Cancer Type
Authors: Gatalica Zoran , Snyder Carrie , Maney Todd , Ghazalpour Anatole , Holterman Daniel A. , Xiao Nianqing , Overberg Peggy , Rose Inga , Basu Gargi D. , Vranic Semir , Lynch Henry T. , Von Hoff Daniel D. , Hamid Omid 
Published: November 2014

Abstract
Cancer cells expressing PD-1 ligands (PD-L1/PD-L2) inhibit immune-modulatory T-cell activation facilitating disease progression. Preliminary clinical trials exploring interruption of PD-1/PD-L1 signaling showed benefit in several cancer types. We analyzed the distribution of PD-1–positive tumor-infiltrating lymphocytes (TIL) and cancer cells' expression of PD-L1 in a molecularly profiled cohort of 437 malignancies (380 carcinomas, 33 sarcomas, and 24 melanomas). We showed that the presence of PD-1+ TILs significantly varied among cancer types (from 0% in extraskeletal myxoid chondrosarcomas to 93% in ovarian cancer), and was generally associated with the increased number of mutations in tumor cells (P = 0.029). Cancer cell expression of PD-L1 varied from absent (in Merkel cell carcinomas) to 100% (in chondro- and liposarcomas), but showed the inverse association with the number of detected mutations (P = 0.004). Both PD-1 and PD-L1 expression were significantly higher in triple-negative breast cancers (TNBC) than in non-TNBC (P &lt; 0.001 and 0.017, respectively). Similarly, MSI-H colon cancers had higher PD-1 and PD-L1 expression than the microsatellite stable tumors (P = 0.002 and 0.02, respectively). TP53-mutated breast cancers had significantly higher PD-1 positivity than those harboring other driver mutations (e.g., PIK3CA; P = 0.002). In non–small cell lung cancer, PD-1/PD-L1 coexpression was identified in 8 cases (19%), which lacked any other targetable alterations (e.g., EGFR, ALK, or ROS1). Our study demonstrated the utility of exploring the expression of two potentially targetable immune checkpoint proteins (PD-1/PD-L1) in a substantial proportion of solid tumors, including some aggressive subtypes that lack other targeted treatment modalities. Cancer Epidemiol Biomarkers Prev; 23(12); 2965–70. ©2014 AACR.
Safety and Efficacy of VCN-01, an Oncolytic Adenovirus Combining Fiber HSG-Binding Domain Replacement with RGD and Hyaluronidase Expression
Authors: Rodríguez-García Alba , Giménez-Alejandre Marta , Rojas Juan J. , Moreno Rafael , Bazan-Peregrino Miriam , Cascalló Manel , Alemany Ramon 
Published: November 2014

Abstract
Purpose: Tumor targeting upon intravenous administration and subsequent intratumoral virus dissemination are key features to improve oncolytic adenovirus therapy. VCN-01 is a novel oncolytic adenovirus that combines selective replication conditional to pRB pathway deregulation, replacement of the heparan sulfate glycosaminoglycan putative-binding site KKTK of the fiber shaft with an integrin-binding motif RGDK for tumor targeting, and expression of hyaluronidase to degrade the extracellular matrix. In this study, we evaluate the safety and efficacy profile of this novel oncolytic adenovirus.
Experimental Design: VCN-01 replication and potency were assessed in a panel of tumor cell lines. VCN-01 tumor-selective replication was evaluated in human fibroblasts and pancreatic islets. Preclinical toxicity, biodistribution, and efficacy studies were conducted in mice and Syrian hamsters.
Results: Toxicity and biodistribution preclinical studies support the selectivity and safety of VCN-01. Antitumor activity after intravenous or intratumoral administration of the virus was observed in all tumor models tested, including melanoma and pancreatic adenocarcinoma, both in immunodeficient mice and immunocompetent hamsters.
Conclusions: Oncolytic adenovirus VCN-01 characterized by the expression of hyaluronidase and the RGD shaft retargeting ligand shows an efficacy–toxicity prolife in mice and hamsters by intravenous and intratumoral administration that warrants clinical testing. Clin Cancer Res; 21(6); 1406–18. ©2014 AACR.
Right Ventricular Function in Heart Failure With Preserved Ejection Fraction
Authors: Mohammed Selma F. , Hussain Imad , AbouEzzeddine Omar F. , Takahama Hiroyuki , Kwon Susan H. , Forfia Paul , Roger Véronique L. , Redfield Margaret M. 
Published: November 2014

Background—
The prevalence and clinical significance of right ventricular (RV) systolic dysfunction (RVD) in patients with heart failure and preserved ejection fraction (HFpEF) are not well characterized.

Methods and Results—

Consecutive, prospectively identified HFpEF (Framingham HF criteria, ejection fraction ≥50%) patients (n=562) from Olmsted County, Minnesota, underwent echocardiography at HF diagnosis and follow-up for cause-specific mortality and HF hospitalization. RV function was categorized by tertiles of tricuspid annular plane systolic excursion and by semiquantitative (normal, mild RVD, or moderate to severe RVD) 2-dimensional assessment. Whether RVD was defined by semiquantitative assessment or tricuspid annular plane systolic excursion ≤15 mm, HFpEF patients with RVD were more likely to have atrial fibrillation, pacemakers, and chronic diuretic therapy. At echocardiography, patients with RVD had slightly lower left ventricular ejection fraction, worse diastolic dysfunction, lower blood pressure and cardiac output, higher pulmonary artery systolic pressure, and more severe RV enlargement and tricuspid valve regurgitation. After adjustment for age, sex, pulmonary artery systolic pressure, and comorbidities, the presence of any RVD by semiquantitative assessment was associated with higher all-cause (hazard ratio=1.35; 95% confidence interval, 1.03–1.77;
P
=0.03) and cardiovascular (hazard ratio=1.85; 95% confidence interval, 1.20–2.80;
P
=0.006) mortality and higher first (hazard ratio=1.99; 95% confidence interval, 1.35–2.90;
P
=0.0006) and multiple (hazard ratio=1.81; 95% confidence interval, 1.18–2.78;
P
=0.007) HF hospitalization rates. RVD defined by tricuspid annular plane systolic excursion values showed similar but weaker associations with mortality and HF hospitalizations.

Conclusions—
In the community, RVD is common in HFpEF patients, is associated with clinical and echocardiographic evidence of more advanced HF, and is predictive of poorer outcomes.
The effects of naloxone on courtship and pairing behaviour in male and female zebra finches: the importance of testing mechanisms using multiple paradigms
Authors: Tomaszycki Michelle L. , Schnelker Joanna H. , Zatirka Brendon P. 
Published: November 2014

Opioids are implicated in social attachments, but their role in avian pair bonds is not well understood. The present study tested the effects of naloxone, an opioid antagonist, on pairing using both a forced-choice and a mixed-sex aviary paradigm. First, three doses of naloxone were systemically administered in males using a repeated measures forced-choice design, partner preference formation was tested on the second day. Males treated with 20 mg/kg sang less undirected song. Males treated with 10 mg/kg of naloxone sang less to the familiar partner than when treated with saline and were less likely to form a partner preference than were other treatments. In females, 10 mg/kg of naloxone in a forced-choice paradigm increased preference for the unfamiliar over the familiar male. Finally, males and females were administered either naloxone (10 mg/kg) or saline in a mixed-sex aviary. In females, naloxone increased pairing behaviours, but had no other effects in either sex. Our findings suggest that the effects of naloxone on pairing-related behaviours are context-dependent; male–male competition may decrease the effects of naloxone on male song and a choice of mates may increase affiliation in females in a semi-naturalistic paradigm, and increase preferences for an unfamiliar partner in a forced-choice paradigm. Our findings highlight the importance of using multiple paradigms to test mechanisms of behaviour. These findings contribute to our understanding of the mechanisms of monogamous relationships and suggest that opioids play a role in male courtship, female affiliation and partner preferences in both sexes of zebra finches, but that context is important.
Coalitions in theory and reality: a review of pertinent variables and processes
Authors: Bissonnette Annie , Perry Susan , Barrett Louise , Mitani John C. , Flinn Mark , Gavrilets Sergey , de Waal Frans B.M. 
Published: November 2014

Coalitions and alliances are ubiquitous in humans and many other mammals, being part of the fabric of complex social systems. Field biologists and ethologists have accumulated a vast amount of data on coalition and alliance formation, while theoretical biologists have developed modelling approaches. With the accumulation of empirical data and sophisticated theory, we are now potentially able to answer a host of questions about how coalitions emerge and are maintained in a population over time, and how the psychology of this type of cooperation evolved. Progress can only be achieved, however, by effectively bridging the communication gap that currently exists between empiricists and theoreticians. In this paper, we aim to do so by asking three questions: (1) What are the primary questions addressed by theoreticians interested in coalition formation, and what are the main building blocks of their models? (2) Do empirical observations support the assumptions of current models, and if not, how can we improve this situation? (3) Has theoretical work led to a better understanding of coalition formation, and what are the most profitable lines of inquiry for the future? Our overarching goal is to promote the integration of theoretical and field biology by motivating empirical scientists to collect data on aspects of coalition formation that are currently poorly quantified and to encourage theoreticians to develop a comprehensive theory of coalition formation that is testable under real-world conditions.
Review of the genus Lesteva Latreille, 1797 (Coleoptera: Staphylinidae: <br />Omaliinae: Anthophagini) of Iran and adjacent territories
Authors: SHAVRIN ALEXEY V. 
Published: November 2014

The type and additional material from adjacent territories of species of the genus Lesteva Latreille, 1797 of Iran are revised. Eight species are recognized, three of which are described as new: L. (s.str.) frischi sp.n. (Iran, Esfahan), L. (s.str.) schawalleri sp.n. (Iran, Elburs) and L. (s.str.) antennata sp.n. (Iran, Golestan). Two synonyms are proposed: L. (s.str.) binotata Reitter, 1901 = L. (s.str.) syriaca Luze, 1903, syn. n., L. (s.str.) longoelytrata longoelytrata (Goeze, 1777) = L. (s.str.) soror Smetana, 1967, syn. n. A key to species known from Iran and new provincial records for L. (s.str.) binotata Reitter, L. (s.str.) longoelytrata longoelytrata (Goeze), L. (s.str.) maculipennis Luze, 1903 and L. (Lestevidia) punctata Erichson, 1839 are provided. L. (s.str.) binotata Reitter and L. (s.str.) maculipennis are redescribed. Aedeagi of all new species, L. (s.str.) binotata, L. (s.str.) longoelytrata longoelytrata and L. (s.str.) maculipennis, as well as the antennae of all species and the variability of elytral maculae for two redescribed species are illustrated.
The Sensitivity of Rainfall Estimation to Error Assumptions in a Bayesian Passive Microwave Retrieval Algorithm
Authors: Elsaesser Gregory S. , Kummerow Christian D. 
Published: November 2014

AbstractThe Goddard profiling algorithm (GPROF) uses Bayesian probability theory to retrieve rainfall over the global oceans. A critical component of GPROF and most Bayes theorem–based retrieval frameworks is the specification of uncertainty in the observations being utilized to retrieve the parameter of interest. In the case of GPROF, for any sensor, uncertainties in microwave brightness temperatures (Tbs) arise from radiative transfer model errors, satellite sensor noise and/or degradation, and nonlinear, scene-dependent Tb offsets added during sensor intercalibration procedures. All mentioned sources impact sensors in a varying fashion, in part because of sensor-dependent fields of view. It is found that small errors in assumed Tb uncertainty (ranging from 0.57 K at 10 GHz to 2.29 K at 85 GHz) lead to a 3.6% change in the retrieved global-average oceanic rainfall rate, and 10%–20% (20%–40%) shifts in the pixel-level (monthly) frequency distributions for given rainfall bins. A mathematical expression describing the sensitivity of retrieved rainfall to uncertainty is developed here. The strong global sensitivity is linked to rainfall variance scaling systematically as Tb varies. For ocean scenes, the same emission-dominated rainfall–Tb physics used in passive microwave rainfall retrieval is also responsible for the substantial underestimation (overestimation) of global rainfall if uncertainty is overestimated (underestimated). Proper uncertainties are required to quantify variability in surface rainfall, assess long-term trends, and provide robust rainfall benchmarks for general circulation model evaluations. The implications for assessing global and regional biases in active versus passive microwave rainfall products, and for achieving rainfall product agreement among a constellation of orbiting microwave radiometers [employed in the Global Precipitation Measurement (GPM) mission], are also discussed.
Prediction of Indian Summer Monsoon Onset Using Dynamical Subseasonal Forecasts: Effects of Realistic Initialization of the Atmosphere
Authors: Alessandri Andrea , Borrelli Andrea , Cherchi Annalisa , Materia Stefano , Navarra Antonio , Lee June-Yi , Wang Bin 
Published: November 2014

Abstract
Ensembles of retrospective 2-month dynamical forecasts initiated on 1 May are used to predict the onset of the Indian summer monsoon (ISM) for the period 1989–2005. The subseasonal predictions (SSPs) are based on a coupled general circulation model and recently they have been upgraded by the realistic initialization of the atmosphere with initial conditions taken from reanalysis. Two objective large-scale methods based on dynamical-circulation and hydrological indices are applied to detect the ISM onset. The SSPs show some skill in forecasting earlier-than-normal ISM onsets, while they have difficulty in predicting late onsets. It is shown that significant contribution to the skill in forecasting early ISM onsets comes from the newly developed initialization of the atmosphere from reanalysis. On one hand, atmospheric initialization produces a better representation of the atmospheric mean state in the initial conditions, leading to a systematically improved monsoon onset sequence. On the other hand, the initialization of the atmosphere allows some skill in forecasting the northward-propagating intraseasonal wind and precipitation anomalies over the tropical Indian Ocean. The northward-propagating intraseasonal modes trigger the monsoon in some early-onset years. The realistic phase initialization of these modes improves the forecasts of the associated earlier-than-normal monsoon onsets. The prediction of late onsets is not noticeably improved by the initialization of the atmosphere. It is suggested that late onsets of the monsoon are too far away from the start date of the forecasts to conserve enough memory of the intraseasonal oscillation (ISO) anomalies and of the improved representation of the mean state in the initial conditions.
Ensemble Typhoon Quantitative Precipitation Forecasts Model in Taiwan
Authors: Hong Jing-Shan , Fong Chin-Tzu , Hsiao Ling-Feng , Yu Yi-Chiang , Tzeng Chian-You 
Published: November 2014

Abstract
In this study, an ensemble typhoon quantitative precipitation forecast (ETQPF) model was developed to provide typhoon rainfall forecasts for Taiwan. The ETQPF rainfall forecast is obtained by averaging the pick-out cases, which are screened using certain criterion based on given typhoon tracks from an ensemble prediction system (EPS). Therefore, the ETQPF model resembles a climatology model. However, the ETQPF model uses the quantitative precipitation forecasts (QPFs) from an EPS instead of historical rainfall observations. Two typhoon cases, Fanapi (2010) and Megi (2010), are used to evaluate the ETQPF model performance. The results show that the rainfall forecast from the ETQPF model, which is qualitatively compared and quantitatively verified, provides reasonable typhoon rainfall forecasts and is valuable for real-time operational applications. By applying the forecast track to the ETQPF model, better track forecasts lead to better ETQPF rainfall forecasts. Moreover, the ETQPF model provides the “scenario” of the typhoon QPFs according to the uncertainty of the forecast tracks. Such a scenario analysis can provide valuable information for risk assessment and decision making in disaster prevention and reduction. Deficiencies of the ETQPF model are also presented, including that the average over the pick-out case usually offsets the extremes and reduces the maximum ETQPF rainfall, the underprediction is especially noticeable for weak phase-locked rainfall systems, and the ETQPF rainfall error is related to the model bias. Therefore, reducing model bias is an important issue in further improving the ETQPF model performance.
Transformative occupational therapy
Authors: Dubouloz Claire-Jehanne 
Published: November 2014

Background. Transformative learning involves critical self-reflection as the motor for transforming values, beliefs, knowledge, and feelings and discovering the new meaning of daily life following a catastrophic injury or illness. Transformation has been conceptualized in various disciplines as a transcendent experience, rebirth process, and meaning-making process and within occupational therapy as a meaning perspective process. Purpose. This Muriel Driver lecture explores the concept of transformation and presents the newly developed Meaning Perspectives Transformation model, constructed from research conducted with several different rehabilitation client groups. Key Issues. The model is characterized by three phases: trigger, changing, and outcomes. A client’s critical self-reflection acts as a catalyst for moving between the phases and is represented in the model as a moment of readiness for change leading to the development of alternative ways of performing. Implications. The Meaning Perspectives Transformation model provides a tool for being an effective occupational therapist, encouraging therapists to listen closely to their clients to identify their weakening and emerging meaning perspectives and enable their occupational evolution and transformation.
The Effect of an Electronic Checklist on Critical Care Provider Workload, Errors, and Performance
Authors: Thongprayoon Charat , Harrison Andrew M. , O’Horo John C. , Berrios Ronaldo A. Sevilla , Pickering Brian W. , Herasevich Vitaly 
Published: November 2014

Purpose: The strategy used to improve effective checklist use in intensive care unit (ICU) setting is essential for checklist success. This study aimed to test the hypothesis that an electronic checklist could reduce ICU provider workload, errors, and time to checklist completion, as compared to a paper checklist. Methods: This was a simulation-based study conducted at an academic tertiary hospital. All participants completed checklists for 6 ICU patients: 3 using an electronic checklist and 3 using an identical paper checklist. In both scenarios, participants had full access to the existing electronic medical record system. The outcomes measured were workload (defined using the National Aeronautics and Space Association task load index [NASA-TLX]), the number of checklist errors, and time to checklist completion. Two independent clinician reviewers, blinded to participant results, served as the reference standard for checklist error calculation. Results: Twenty-one ICU providers participated in this study. This resulted in the generation of 63 simulated electronic checklists and 63 simulated paper checklists. The median NASA-TLX score was 39 for the electronic checklist and 50 for the paper checklist ( P = .005). The median number of checklist errors for the electronic checklist was 5, while the median number of checklist errors for the paper checklist was 8 ( P = .003). The time to checklist completion was not significantly different between the 2 checklist formats ( P = .76). Conclusion: The electronic checklist significantly reduced provider workload and errors without any measurable difference in the amount of time required for checklist completion. This demonstrates that electronic checklists are feasible and desirable in the ICU setting.
Lupus enteritis: clinical characteristics and predictive factors for recurrence
Authors: Koo B S , Hong S , Kim Y J , Kim Y-G , Lee C-K , Yoo B 
Published: November 2014

Objectives To compare the clinical characteristics of lupus enteritis (LE) and non-enteric lupus (non-LE) patients and identify predictors of LE recurrence. Methods We retrospectively reviewed the medical records of 62 systemic lupus erythematosus (SLE) patients in a tertiary hospital who experienced enteric symptoms and underwent abdominal computed tomography scanning between January 1997 and December 2013. We compared the clinical characteristics between LE and non-LE patients and between recurrent LE and non-recurrent LE cases. Results Out of 62 SLE patients with enteric symptoms, 46 cases (74%) were compatible with LE based on computed tomography findings. The C4 level was decreased in the LE group compared with the non-LE group (9.0 ± 5.6 vs. 12.3 ± 6.2, p = 0.032). Recurrence of LE was observed in 14 patients (28%). Initial involvement at the colon (79% vs. 41%, p = 0.026) and bladder with/without the ureter was more common in the recurrent group (57% vs. 25%, p = 0.048). By multivariate analysis, the hazard ratios of variables associated with recurrence were 4.689 for colon involvement (95% confidence interval: 1.245–17.659, p = 0.0220] and 5.468 for cystitis with/without ureteritis (95% confidence interval: 1.629–18.360, p = 0.006). Conclusion Colon and urinary tract involvement in LE patients may be associated with the recurrence of LE.
Predictors of the response to treatment in acute lupus hemophagocytic syndrome
Authors: Takahashi H , Tsuboi H , Kurata I , Takahashi H , Inoue S , Ebe H , Yokosawa M , Hagiwara S , Hirota T , Asashima H , Kaneko S , Kawaguchi H , Kurashima Y , Miki H , Umeda N , Kondo Y , Ogishima H , Suzuki T , Matsumoto I , Sumida T 
Published: November 2014

Objective The objective of this paper is to identify predictors for the response to treatment of acute lupus hemophagocytic syndrome (ALHS). Methods We reviewed seven cases with ALHS admitted to our hospital and published ALHS cases identified in the 2001–2014 Medline database, and then conducted univariate and multivariate analyses to identify predictors for the response to treatment. Results Review of our cases showed a significant and negative correlation between serum ferritin and anti-DNA antibody ( p = 0.0025). All three patients treated with cyclosporine A (CsA) were considered responders despite high serum ferritin and corticosteroid resistance. We also reviewed 93 patients with ALHS identified in 46 articles. Multiple logistic regression analysis identified C-reactive protein (CRP) (OR 0.83, p = 0.042) and hemoglobin (OR 1.53, p = 0.026) measured at diagnosis of ALHS as significant predictors of the response to corticosteroid monotherapy. Moreover, among 32 patients treated with CsA, serum ferritin was significantly higher in CsA responders (12163 ± 16864 µg/l, n = 22) than in non-responders (3456 ± 6267/µg/l, p = 0.020, n = 10). Leukocyte count was significantly lower in the CsA responders (1940.0 ± 972.3/µl) than in the non-responders (3253 ± 2198/µl, p = 0.034). Conclusion Low CRP and high hemoglobin can predict a positive response to corticosteroid monotherapy while high serum ferritin and low leukocyte count can predict a positive response to CsA in patients with ALHS and therefore, when corticosteroid monotherapy is not effective in such cases, CsA could be the first choice of an additional immunosuppressive agent.