bluuebunny/crossref_metadata_2025_split huggingface dataset:
Programming of Influenza Vaccine Broadness and Persistence by Mucoadhesive Polymer-Based Adjuvant Systems
Authors: Noh Hyun Jong , Chowdhury Mohammed Y. E. , Cho Seonghun , Kim Jae-Hoon , Park Hye Sun , Kim Chul-Joong , Poo Haryoung , Sung Moon-Hee , Lee Jong-Soo , Lim Yong Taik 
Published: July 2015

Abstract
The development of an anti-influenza vaccine with the potential for cross-protection against seasonal drift variants as well as occasionally emerging reassortant viruses is essential. In this study, we successfully generated a novel anti-influenza vaccine system combining conserved matrix protein 2 (sM2) and stalk domain of hemagglutinin (HA2) fusion protein (sM2HA2) and poly-γ-glutamic acid (γ-PGA)–based vaccine adjuvant systems that can act as a mucoadhesive delivery vehicle of sM2HA2 as well as a robust strategy for the incorporation of hydrophobic immunostimulatory 3-O-desacyl-4′-monophosphoryl lipid A (MPL) and QS21. Intranasal coadministration of sM2HA2 and the combination adjuvant γ-PGA/MPL/QS21 (CA-PMQ) was able to induce a high degree of protective mucosal, systemic, and cell-mediated immune responses. The sM2HA2/CA-PMQ immunization was able to prevent disease symptoms, confering complete protection against lethal infection with divergent influenza subtypes (H5N1, H1N1, H5N2, H7N3, and H9N2) that lasted for at least 6 mo. Therefore, our data suggest that mucosal administration of sM2HA2 in combination with CA-PMQ could be a potent strategy for a broad cross-protective influenza vaccine, and CA-PMQ as a mucosal adjuvant could be used for effective mucosal vaccines.
A Microeconometric Analysis of the Springboard Subsidiary: The Case of Spanish Firms
Authors: Marulanda Carolina Caicedo , Pla-Barber José , Darder Fidel León , Rodríguez Jhon James Mora 
Published: July 2015

Abstract
This paper provides a microeconometric analysis of the distinctive characteristics of springboard subsidiaries that have a positive impact on the subsidiaries’ performance. Based on panel data estimations for subsidiaries of European multinational companies with a presence in Spain, the authors found that if the subsidiary is located in the springboard country, then the performance improvement (increase in profit margin) of the subsidiary is about 49 percentage points. When the Spanish subsidiary is considered a springboard subsidiary, its performance is 7.7 percentage points higher than the performance of other subsidiaries that are not springboard subsidiaries. If the subsidiary has a technological relationship with another subsidiary, its performance is 6.7 percentage points higher than the performance of other subsidiaries that do not have a technological relationship. Finally, when the firm has low autonomy, the performance of the subsidiary is 6.2 percentage points lower than that of firms that are independent or have a high level of autonomy.
Faith and Doubt: The Noematic Dimensions of Belief in Husserl
Authors: McNeilly Jodie 
Published: July 2015

ABSTRACTIn examining Husserl's noesis–noema correlate, which characterizes his intentionality thesis of 1913, this article argues toward “presentation” as a sufficient mode of givenness in accounting for religious phenomena by demonstrating how an intentional analysis of faith and doubt is possible if one's regard is directed toward the noetic moment of believing and its corresponding noema: the “believed as believed.” This will be shown by directly engaging with the eidetic laws of Husserl's series of belief modalities.
L’orientation temporelle et la consommation de substances psychoactives des adolescents et jeunes adultes
Authors: Acier Didier , Facy Françoise , Pilet Jean-Luc , Chaillou Carmen 
Published: July 2015

Introduction. L’orientation temporelle est une donnée essentielle du psychisme humain, qui module notre façon de nous situer par rapport aux temps de la vie. Elle est la perception subjective, dans l’ici et maintenant, du positionnement psychique à l’égard du passé, du présent et du futur. Plusieurs jeunes rencontrés en consultation psychologique présentent une orientation confuse au temps, étant quelquefois englués dans des souvenirs ou dans une suite incessante d’activités sans temps d’arrêt. Le test d’orientation temporelle (TOT) vise à mesurer ce rapport au temps de la vie, à partir de quatre dimensions : 1) le court terme ; 2) l’anticipation ; 3) l’immédiateté ; 4) le long terme. Objectifs. Cette étude présente les liens entre différentes dimensions de l’orientation temporelle et la consommation de substances psychoactives (tabac, alcool et cannabis). Elle présente aussi une façon d’utiliser le test d’orientation temporelle dans le travail auprès d’adolescents et de jeunes adultes en situation à risque. Méthodes. L’échantillon est constitué de 507 jeunes âgés de 15 à 26 ans résidents de la région nantaise et issus de plusieurs établissements d’enseignement. Les outils utilisés sont le test d’orientation temporelle et des mesures de consommation de substances. Résultats. Les résultats montrent des corrélations significatives entre la consommation et plusieurs dimensions de l’orientation temporelle. Ainsi, les orientations centrées sur l’immédiateté et le court terme sont des prédicteurs de la consommation d’alcool, de tabac et de cannabis. Conclusion. Cette étude avance que l’orientation temporelle est un construit psychologique utile pour travailler avec des jeunes à risques.
Modélisation de la surface piézométrique des aquifères fissurés en zone de socle précambrien métamorphisé : cas du bassin versant du Sassandra (sud-ouest de la Côte d’Ivoire)
Authors: Yao Théodore Koffi , Fouché Olivier , Kouadio Emmanuel Konan , Oga Marie-Solange , Lasm Théophile 
Published: July 2015

Les niveaux piézométriques dans les aquifères de socle en Côte d’Ivoire sont mal connus du fait de la complexité du substratum géologique. Ce travail a pour objectif de modéliser l’altitude du niveau piézométrique des aquifères situés en milieu cristallin et cristallophyllien, notamment dans le bassin versant du Sassandra, au sud-ouest de la Côte d’Ivoire. En exploitant la méthode de la corrélation linéaire entre la dénivellation de la surface du sol et la surface de base des thalwegs d’une part et la dénivellation entre la surface piézométrique et la surface de base des thalwegs d’autre part, nous avons établi des équations qui permettent de déterminer les niveaux piézométriques et de compenser ainsi les lacunes dans leur connaissance. Ces travaux s’appuient sur des données de terrain, des fiches techniques de forage, des cartes (topographique et géologique) et un extrait du Modèle numérique d’Altitude (MNA) du sud-ouest ivoirien.
L’interprétation mathématique des résultats a permis, au travers des équations établies, de calculer directement le niveau piézométrique en tout point de la zone d’étude. La carte piézométrique ainsi obtenue montre que le niveau piézométrique est en moyenne 7 m en dessous du sol lorsque l’on prend comme référence la surface de base des thalwegs. La surface piézométrique est corrélée à la surface topographique. La superposition de la carte piézométrique à celle du réseau hydrographique montre qu’à l’échelle de l’analyse réalisée, la circulation de l’eau souterraine est calquée sur celle des eaux de surface ; bassins versants hydrogéologique et topographique se superposent, montrant ainsi le lien entre les eaux de surface et les eaux souterraines. Ce résultat pourra aider à la gestion intégrée des ressources en eau souterraine et de surface surtout face à la vulnérabilité aux pesticides qui sont fréquemment utilisés dans la zone étudiée.
Effect of Excessive Body Weight on Foot Arch Changes in Preschoolers
Authors: Jankowicz-Szymanska Agnieszka , Mikolajczyk Edyta 
Published: July 2015

Background
A stable standing posture, and effective and aesthetic gait, depend heavily on correct anatomical construction of the feet, thanks to which they can play their important role. The shape and height of the foot arches are already formed in the preschool and early school years; therefore, abnormalities and disorders in children's feet, and correlations between foot formation and somatic build, are still crucial and interesting issues for orthopedists, pediatricians, physiotherapists, and podiatrists. This study deals with changes in the height of the longitudinal and transverse arches of the foot in 4- to 6-year-old children.

Methods
A total of 102 boys and 105 girls took part in a 24-month study in which their body weight, height, body mass index, and Clarke's and gamma angles were measured. The analysis also focused on correlations among sex, nutritional status, and changes in foot arch height.

Results
It was discovered that sex did not considerably affect Clarke's and gamma angle values. However, it was found that between ages 4 and 6 years, the proportion of overweight and obese boys and girls increased, and the medial longitudinal arch of the foot had a tendency to collapse in those with excessive body weight. The effect of nutritional status on the transverse arch of the foot is rather dubious.

Conclusions
In light of these findings, therapeutic programs for preventing foot deformities in children should also focus on body weight control.
Scale‐aware parameterization of liquid cloud inhomogeneity and its impact on simulated climate in CESM
Authors: Xie Xin , Zhang Minghua 
Published: July 2015

AbstractUsing long‐term radar‐based ground measurements from the Atmospheric Radiation Measurement Program, we derive the inhomogeneity of cloud liquid water as represented by the shape parameter of a gamma distribution. The relationship between the inhomogeneity and the model grid size as well as atmospheric condition is presented. A larger grid scale and more unstable atmosphere are associated with larger inhomogeneity that is described by a smaller shape parameter. This relationship is implemented as a scale‐aware parameterization of the liquid cloud inhomogeneity in the Community Earth System Model (CESM) in which the shape parameter impacts the cloud microphysical processes. When used in the default CESM1 with the finite‐volume dynamic core where a constant liquid inhomogeneity parameter was assumed, it reduces the cloud inhomogeneity in high latitudes and increases it in low latitudes. This is due to both the smaller (larger) grid size in high (low) latitudes in the longitude‐latitude grid setting of CESM and the more stable (unstable) atmosphere. The single‐column model and general circulation model sensitivity experiments show that the new parameterization increases the cloud liquid water path in polar regions and decreases it in low latitudes. An advantage of the parameterization is that it can recognize the spatial resolutions of the CESM without special tuning of the cloud water inhomogeneity parameter.
Initial Benchmarking of the Quality of Medical Care in Childhood‐Onset Systemic Lupus Erythematosus
Authors: Mina Rina , Harris Julia G. , Klein‐Gitelman Marisa S. , Appenzeller Simone , Centeville Maraisa , Eskra Diane , Huggins Jennifer L. , Johnson Anne L. , Khubchandani Raju , Khandekar Prachi , Lee Jiha , Liu Hai Mei , Pendl Joshua D. , Silva Clovis A. , Silva Marco F. , Zaal Ahmad I. , DeWitt Esi Morgan , Ardoin Stacy P. , Brunner Hermine I. 
Published: July 2015

ObjectiveTo assess the quality of medical care in childhood‐onset systemic lupus erythematosus (SLE) at tertiary pediatric rheumatology centers as measured by observance of SLE quality indicators (SLE‐QIs).MethodsInternational consensus has been achieved for childhood‐onset SLE‐QIs capturing medical care provision in 9 domains: diagnostic testing, education of cardiovascular (CV) risk and lifestyles, lupus nephritis (LN), medication management, bone health, ophthalmologic surveillance, transition, pregnancy, and vaccination. Using medical record information, the level of performance of these childhood‐onset SLE‐QIs was assessed in childhood‐onset SLE populations treated at 4 tertiary pediatric rheumatology centers in the US, 2 in Brazil, and 1 center in India.ResultsA total of 483 childhood‐onset SLE patients were assessed. Care for the 310 US patients differed markedly for childhood‐onset SLE‐QIs addressing LN, bone health, vaccinations, education on CV risk, and transition planning. Performance of safety blood testing for medications was high at all centers. Despite often similar performance on the childhood‐onset SLE‐QI, access to kidney biopsies was lower in Brazil than in the US. Irrespective of the country of practice, larger centers tended to meet the childhood‐onset SLE‐QIs more often than smaller centers.ConclusionThe childhood‐onset SLE‐QIs, evidence‐based minimum standards of medical care, are not consistently met in the US or some other countries outside the US. This has the potential to contribute to suboptimal childhood‐onset SLE outcomes.
Hydroxoiridium/Chiral Diene Complexes as Effective Catalysts for Asymmetric Annulation of α‐Oxo‐ and Iminocarboxamides with 1,3‐Dienes
Authors: Hatano Miyuki , Nishimura Takahiro 
Published: July 2015

AbstractThe asymmetric [3+2] annulation of α‐oxo‐ and α‐iminocarboxamides with 1,3‐dienes catalyzed by hydroxoiridium/chiral diene complexes was realized, giving high yields of the corresponding γ‐lactams with high enantioselectivity.
Synthesis, characterization, metal sorption, and biological activity of poly(N‐heterocylic acrylamide)
Authors: Al‐Fulaij Othman A. , Elassar Abdel‐Zaher A. , El‐asmy Ahmed F. 
Published: July 2015

ABSTRACTN‐heterocyclic acrylamide monomers were prepared and then transferred to the corresponding polymers to be used as an efficient chelating agent. Polymers reacted with metal nitrate salts (Cu2+, Pb2+,Mg2+, Cd2+, Ni2+, Co2+,Fe2+) at 150°C to give metal‐polymer complexes. The selectivity of the metal ions using prepared polymers from an aqueous mixture containing different metal ion sreflected that the polymer having thiazolyl moiety more selective than that containing imidazolyl or pyridinyl moieties. Ion selectivity of poly[N‐(benzo[d]thiazol‐2‐yl)acrylamide] showed higher selectivity to many ions e.g. Fe3+, Pb2+, Cd2+, Ni2+, and Cu2+. While, that of poly[N‐(pyridin‐4‐yl)acrylamide] is found to be high selective to Fe3+and Cu2+only. Energy dispersive spectroscopy measurements, morphology of the polymers and their metallopolymer complexes, thermal analysis and antimicrobial activity were studied. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2015,132, 42712.
A 1,1‐Carboboration Route to Bora‐Nazarov Systems
Authors: Ge Fang , Türkyilmaz Fatma , Daniliuc Constantin G. , Siedow Melanie , Eckert Hellmut , Kehr Gerald , Erker Gerhard 
Published: July 2015

AbstractHydroboration of the conjugated enynes 1 a and 1 b with Piers’ borane [HB(C6F5)2] gave the respective dienylboranes trans‐2 c and trans‐2 d. Their photolysis resulted in the formation of the dihydroborole products 3 c and 3 d. Both were converted to their pyridine adducts 5 c and 5 d, respectively. Compounds 3 c and 5 c,d were characterized by X‐ray diffraction. The reaction of the bis(enynyl)boranes 6 a and 6 b with B(C6F5)3 resulted in the formation of the dihydroboroles 7 a and 7 b, respectively. This reaction is thought to proceed by 1,1‐carboboration of one of the enynyl substituents at boron to generate the dienylborane intermediates 8 a/8 b, followed by thermally induced bora‐Nazarov ring‐closure and subsequent stabilizing 1,2‐pentafluorophenyl group migration from boron to carbon. Compound 7 a was characterized by X‐ray diffraction and solid‐state 11B NMR spectroscopy.
Discovery of a new blue quasar: SDSS J022218.03–062511.1
Authors: Fix M. B. , Smith J. A. , Tucker D. L. , Wester W. , Annis J. 
Published: July 2015

AbstractWe report the discovery of a bright blue quasar: SDSS J022218.03–062511.1. This object was discovered spectroscopically while searching for hot white dwarfs that may be used as calibration sources for large sky surveys such as the Dark Energy Survey or the Large Synoptic Survey Telescope project. We present the calibrated spectrum, spectral line shifts and report a redshift of z = 0.521±0.0015 and a rest‐frame g‐band luminosity of 8.71×1011 L⊙. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The Gaia spectrophotometric standard stars survey: II. Instrumental effects of six ground‐based observing campaigns
Authors: Altavilla G. , Marinoni S. , Pancino E. , Galleti S. , Ragaini S. , Bellazzini M. , Cocozza G. , Bragaglia A. , Carrasco J. M. , Castro A. , Di Fabrizio L. , Federici L. , Figueras F. , Gebran M. , Jordi C. , Masana E. , Schuster W. , Valentini G. , Voss H. 
Published: July 2015

AbstractThe Gaia SpectroPhotometric Standard Stars (SPSS) survey started in 2006, was awarded almost 450 observing nights and accumulated almost 100000 raw data frames with both photometric and spectroscopic observations. Such large observational effort requires careful, homogeneous, and automatic data reduction and quality control procedures. In this paper, we quantitatively evaluate instrumental effects that might have a significant (i.e., ≥1 %) impact on the Gaia SPSS flux calibration. The measurements involve six different instruments, monitored over the eight years of observations dedicated to the Gaia flux standards campaigns: DOLORES@TNG in La Palma, EFOSC2@NTT and ROSS@REM in La Silla, CAFOS@2.2m in Calar Alto, BFOSC@Cassini in Loiano, and LaRuca@1.5m in San Pedro Mártir. We examine and quantitatively evaluate the following effects: CCD linearity and shutter times, calibration frames stability, lamp flexures, second order contamination, light polarization, and fringing. We present methods to correct for the relevant effects which can be applied to a wide range of observational projects at similar instruments. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A review of East Asian reports of aurorae and comets circa AD 775
Authors: Chapman J. , Neuhäuser D.L. , Neuhäuser R. , Csikszentmihalyi M. 
Published: July 2015

AbstractGiven that a strong 14C variation in AD 775 has recently been suggested to be due to the largest solar flare ever recorded in history, it is relevant to investigate whether celestial events observed around that time may have been aurorae, possibly even very strong aurorae, or otherwise related to the 14C variation (e.g. a suggested comet impact with Earth's atmosphere). We critically review several celestial observations from AD 757 to the end of the 770s, most of which were previously considered to be true, and in some cases, strong aurorae; we discuss in detail the East Asian records and their wording. We conclude that probably none among the events after AD 770 was actually an aurora, including the event in AD 776 Jan, which was misdated for AD 774 or 775; the observed white qi phenomenon that happened above the moon in the south‐east was most probably a halo effect near the full Moon – too late in any case to be related to the 14C variation in AD 774/5. There is another report of a similar (or identical) white qi phenomenon above the moon, reported just before a comet observation and dated to AD 776 Jan; the reported comet observed by the Chinese was misdated to AD 776, but actually sighted in AD 767. Our critical review of East Asian reports of aurorae circa AD 775 shows some very likely true Chinese auroral displays observed and reported for AD 762; there were also several events prior to AD 771 that may have been aurorae but are questionable. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Engineering a novel biosynthetic pathway in Escherichia coli for production of renewable ethylene glycol
Authors: Pereira Brian , Zhang Haoran , De Mey Marjan , Lim Chin Giaw , Li Zheng‐Jun , Stephanopoulos Gregory 
Published: July 2015

ABSTRACTEthylene glycol (EG) is an important commodity chemical with broad industrial applications. It is presently produced from petroleum or natural gas feedstocks in processes requiring consumption of significant quantities of non‐renewable resources. Here, we report a novel pathway for biosynthesis of EG from the renewable sugar glucose in metabolically engineered Escherichia coli. Serine‐to‐EG conversion was first achieved through a pathway comprising serine decarboxylase, ethanolamine oxidase, and glycolaldehyde reductase. Serine provision in E. coli was then enhanced by overexpression of the serine‐biosynthesis pathway. The integration of these two parts into the complete EG‐biosynthesis pathway in E. coli allowed for production of 4.1 g/L EG at a cumulative yield of 0.14 g‐EG/g‐glucose, establishing a foundation for a promising biotechnology. Biotechnol. Bioeng. 2016;113: 376–383. © 2015 Wiley Periodicals, Inc.
Improved Performance of VOx‐Coated Li‐Rich NMC Electrodes
Authors: Laszczynski Nina , von Zamory Jan , Kalhoff Julian , Loeffler Nicholas , Chakravadhanula Venkata Sai Kiran , Passerini Stefano 
Published: July 2015

AbstractA VOx coating of Li1.2Mn0.56Ni0.16Co0.08O2, made through a low‐temperature annealing process (350 °C), results in the formation of a protecting layer, which enables electrodes to be prepared with an aqueous binder, offering a significantly improved electrochemical performance. The comparison with uncoated electrodes demonstrates the significantly improved performance of VOx‐coated Li1.2Mn0.56Ni0.16Co0.08O2, which substantially outperforms the uncoated material by 30 mAh g−1 at moderate rates. The VOx coating is found to prevent the contact of Li1.2Mn0.56Ni0.16Co0.08O2 with water from the aqueous‐binder processing, preventing leaching of metal cations. Upon cell operation, the coating delays the transformation of the active layer material into the spinel phase, occurring at low voltages, thus delaying its typical capacity fade upon cycling. Finally, the coating contributes to the overall material capacity, while ensuring the lithium deintercalation and intercalation processes.
Single‐Walled Carbon Nanotubes/Au–Mesoporous Silica Janus Nanoparticles as Building Blocks for the Preparation of a Bienzyme Biosensor
Authors: Boujakhrout Abderrahmane , Sánchez Enrique , Díez Paula , Sánchez Alfredo , Martínez‐Ruiz Paloma , Parrado Concepción , Pingarrón José M. , Villalonga Reynaldo 
Published: July 2015

AbstractGold–mesoporous silica Janus nanoparticles were prepared through a masking strategy and further employed as building blocks for the preparation of bienzyme biosensors through toposelective immobilization of the corresponding enzymes. The system was evaluated by immobilizing glucose oxidase and horseradish peroxidase on the Au and mesoporous silica faces, respectively. The anisotropic nanoparticles were deposited on glassy carbon electrodes coated with single‐walled carbon nanotubes in order to construct an amperometric biosensor for glucose detection. The enzymatic electrode showed excellent electroanalytical performance with a fast response in about 6 s, a linear range of 490 nm–600 μm, a high sensitivity of 4.3 mA M−1 , and a low detection limit of 360 nm for glucose. This biosensor was successfully employed to determine the content of this monosaccharide in commercial soft drink samples.
Intramolecular Redox‐Mannich Reactions: Facile Access to the Tetrahydroprotoberberine Core
Authors: Ma Longle , Seidel Daniel 
Published: July 2015

AbstractCyclic amines such as pyrrolidine undergo redox‐annulations with 2‐formylaryl malonates. Concurrent oxidative amine α‐CH bond functionalization and reductive N‐alkylation render this transformation redox‐neutral. This redox‐Mannich process provides regioisomers of classic Reinhoudt reaction products as an entry to the tetrahydroprotoberberine core, enabling the synthesis of (±)‐thalictricavine and its epimer. An unusually mild amine‐promoted dealkoxycarbonylation was discovered in the course of these studies.
ChemInform Abstract: Single‐Crystal Structure Determination of NO2SbF6, XeF5SbF6 and XeF5Sb2F11.
Authors: Mazej Zoran , Goreshnik Evgeny A. 
Published: July 2015

AbstractThe title compounds are prepared according to the literature and used for single crystal growth in a T‐shaped fluoroethylene‐hexafluoropropylene crystallization apparatus.