bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chlamydia pneumoniae Infection Promotes Vascular Smooth Muscle Cell Migration through a Toll-Like Receptor 2-Related Signaling Pathway
Authors: Wang Beibei , Zhang Lijun , Zhang Tengteng , Wang Haiwei , Zhang Junxia , Wei Junyan , Shen Bingling , Liu Xin , Xu Zhelong , Zhang Lijun 
Published: October 2013

ABSTRACT

The migration of vascular smooth muscle cells (VSMCs) from the media to the intima is proposed to be a key event in the development of atherosclerosis. Recently, we reported that
Chlamydia pneumoniae
infection is involved in VSMC migration. However, the exact mechanisms for
C. pneumoniae
infection-induced VSMC migration are not yet well elucidated. In this study, we examined the role of the Toll-like receptor 2 (TLR2) activation-related signaling pathway in VSMC migration induced by
C. pneumoniae
infection. An Affymetrix-based gene expression array was conducted to identify the changes of gene expression in rat primary VSMCs (rVSMCs) infected with
C. pneumoniae
. Both the microarray analysis and quantitative real-time reverse transcription (RT)-PCR revealed that TLR2 mRNA expression was strongly upregulated 12 h after
C. pneumoniae
infection. RT-PCR and Western blot analysis further showed that the expression levels of TLR2 mRNA and protein significantly increased at the different time points after infection. Immunocytochemical analysis suggested a TLR2 recruitment to the vicinity of
C. pneumoniae
inclusions. Cell migration assays showed that the TLR2-neutralizing antibody could significantly inhibit
C. pneumoniae
infection-induced rVSMC migration. In addition,
C. pneumoniae
infection stimulated Akt phosphorylation at Ser 473, which was obviously suppressed by the PI3K inhibitor LY294002, thereby inhibiting rVSMC migration caused by
C. pneumoniae
infection. Furthermore, both the infection-induced Akt phosphorylation and rVSMC migration were suppressed by the TLR2-neutralizing antibody. Taken together, these data suggest that
C. pneumoniae
infection can promote VSMC migration possibly through the TLR2-related signaling pathway.
40
Ar/
39
Ar hornblende provenance clues about Heinrich event 3 (H3)
Authors: Downing Greg E. , Hemming Sidney R. , Jost Anne , Roy Martin 
Published: October 2013

Abstract

Iceberg discharges into the North Atlantic are important sources of fresh water, and the sediments they deposit can provide constraints on which sectors of different ice sheets were contributing icebergs.
40
Ar/
39
Ar ages of sand-sized hornblende grains provide useful constraints on IRD (ice-rafted detritus) source areas.

Heinrich events are intervals of anomalously high percentages of IRD in marine sediment cores of the North Atlantic IRD belt. In contrast to the others, Heinrich event 3 (H3) records a significantly lower flux of IRD. This study compares
40
Ar/
39
Ar hornblende age distributions from the interval around and including H3 in giant gravity core EW9303-GGC31 from Orphan Knoll, in the southern part of the Labrador Sea, with piston core V28-82 in the eastern part of the North Atlantic IRD belt. Collectively, these results confirm that H3 represents a Hudson Strait IRD event, but that it was smaller than during H1, H2, H4 and H5, and therefore comprises only a small fraction of the detritus at the eastern North Atlantic location of V28-82. These results support a previously published interpretation of across-strait ice flow during H3 at Hudson Strait.

Supplementary material:

Appendix 1 is
40
Ar/
39
Ar data from core EW9303-GGC31; Appendix 2 is grain counts across H3 from core V28-82; Appendix 3 is
40
Ar/
39
Ar data from core V28-82; these are available at
http://www.geolsoc.org.uk/SUP18631
.
Perspectives on
40
Ar/
39
Ar dating
Authors: McDougall Ian 
Published: October 2013

Abstract

Isotopic dating of geological samples using the K/Ar method and its variant, the
40
Ar/
39
Ar dating technique, provides ages that in favourable circumstances are precise and accurate to within 1%. Limiting factors include the accuracy of the decay constants for
40
K and the age of neutron fluence monitor minerals. For rapidly cooled igneous rocks, a K/Ar or
40
Ar/
39
Ar age normally will give a good estimate of the age of eruption, but for slowly cooled igneous rocks or metamorphic rocks an age measured on a sample is likely to be a cooling age. As
40
Ar*/
39
Ar
K
ratios can now be determined often to better than 0.1%, the main limitation on accuracy relates to how well the
40
K decay constants are known. Better determination of the β
−
and γ decays of
40
K, the basis for the decay constants, is suggested at the present time, rather than adoption of new decay constants linked to another decay scheme. Until improved independently measured decay constants for
40
K become available, there may be some circumstances where the newly proposed decay constants need to be used, especially when comparing ages on volcanic igneous rocks with those measured in another system.
CHEBINT
Authors: Poppe Koen , Cools Ronald 
Published: October 2013

We present the fast approximation of multivariate functions based on Chebyshev series for two types of Chebyshev lattices and show how a fast Fourier transform (FFT) based discrete cosine transform (DCT) can be used to reduce the complexity of this operation. Approximating multivariate functions using rank-1 Chebyshev lattices can be seen as a one-dimensional DCT while a full-rank Chebyshev lattice leads to a multivariate DCT.
We also present a MATLAB/Octave toolbox which uses this fast algorithms to approximate functions on a axis aligned hyper-rectangle. Given a certain accuracy of this approximation, interpolation of the original function can be achieved by evaluating the approximation while the definite integral over the domain can be estimated based on this Chebyshev approximation. We conclude with an example for both operations and actual timings of the two methods presented.
Virtual private social networks and a facebook implementation
Authors: Conti Mauro , Hasani Arbnor , Crispo Bruno 
Published: October 2013

The popularity of Social Networking Sites (SNS) is growing rapidly, with the largest sites serving hundreds of millions of users and their private information. The privacy settings of these SNSs do not allow the user to avoid sharing some information (e.g., name and profile picture) with all the other users. Also, no matter the privacy settings, this information is always shared with the SNS (that could sell this information or be hacked). To mitigate these threats, we recently introduced the concept of Virtual Private Social Networks (VPSNs).
In this work we propose the first complete architecture and implementation of VPSNs for Facebook. In particular, we address an important problem left unexplored in our previous research—that is the automatic propagation of updated profiles to all the members of the same VPSN. Furthermore, we made an in-depth study on performance and implemented several optimization to reduce the impact of VPSN on user experience.
The proposed solution is lightweight, completely distributed, does not depend on the collaboration from Facebook, does not have a central point of failure, it offers (with some limitations) the same functionality as Facebook, and apart from some simple settings, the solution is almost transparent to the user. Thorough experiments, with an extended set of parameters, we have confirmed the feasibility of the proposal and have shown a very limited time-overhead experienced by the user while browsing Facebook pages.
Free Somatostatin Receptor Fraction Predicts the Antiproliferative Effect of Octreotide in a Neuroendocrine Tumor Model: Implications for Dose Optimization
Authors: Heidari Pedram , Wehrenberg-Klee Eric , Habibollahi Peiman , Yokell Daniel , Kulke Matthew , Mahmood Umar 
Published: October 2013

Abstract
Somatostatin receptors (SSTR) are highly expressed in well-differentiated neuroendocrine tumors (NET). Octreotide, an SSTR agonist, has been used to suppress the production of vasoactive hormones and relieve symptoms of hormone hypersecretion with functional NETs. In a clinical trial, an empiric dose of octreotide treatment prolonged time to tumor progression in patients with small bowel neuroendocrine (carcinoid) tumors, irrespective of symptom status. However, there has yet to be a dose optimization study across the patient population, and methods are currently lacking to optimize dosing of octreotide therapy on an individual basis. Multiple factors such as total tumor burden, receptor expression levels, and nontarget organ metabolism/excretion may contribute to a variation in SSTR octreotide occupancy with a given dose among different patients. In this study, we report the development of an imaging method to measure surface SSTR expression and occupancy level using the PET radiotracer 68Ga-DOTATOC. In an animal model, SSTR occupancy by octreotide was assessed quantitatively with 68Ga-DOTATOC PET, with the finding that increased occupancy resulted in decreased tumor proliferation rate. The results suggested that quantitative SSTR imaging during octreotide therapy has the potential to determine the fractional receptor occupancy in NETs, thereby allowing octreotide dosing to be optimized readily in individual patients. Clinical trials validating this approach are warranted. Cancer Res; 73(23); 6865–73. ©2013 AACR.
L’allègement du chagrin partagé : 2 Co 2:5
Authors: Assaël Jacqueline 
Published: October 2013

Résumé
Les traductions données du verset 2 Co 2:5 dans toute la tradition exégétique sont multiples et variées dans leurs détails. Elles prêtent d’ailleurs toutes à Paul une pensée qui manque de fermeté et un mode d’énonciation très maladroit. Ces deux caractéristiques laissent supposer que l’interprétation de ce texte n’est pas suffisamment clarifiée. Or, le contenu de ce verset s’insère dans une réflexion sur la contagion délétère ou fructueuse du chagrin. L’apôtre évoque alors son expérience de partage de sa peine auprès des Corinthiens. Elle lui a procuré un allègement de sa douleur. L’affection fraternelle a agi de façon à ce « qu’il ne soit pas trop accablé. » La valeur passive de la forme verbale restitue à cette phrase un degré de spiritualité, un sens cohérent et net, ainsi qu’une élégance dans l’expression des sentiments.
Notes on a collection of Meconematinae (Orthoptera: Tettigoniidae) from Damingshan, Guangxi, China with the description of a new species
Authors: Shi Fu-Ming , Bai Jin-Rong , Zhang Ying , Chang Yan-Lin 
Published: October 2013

This paper deals with 6 genera and 10 species of the tribe Meconematini from Damingshan, Guangxi, China, one of which is a new species, i.e. Xizicus (Eoxizicus) laminatus Shi sp. nov.
Validation of a UV-to-RF High-Spectral-Resolution Atmospheric Boundary Layer Characterization Tool
Authors: Fiorino Steven T. , Randall Robb M. , Via Michelle F. , Burley Jarred L. 
Published: October 2013

AbstractThis paper demonstrates the capability of the Laser Environmental Effects Definition and Reference (LEEDR) model to accurately characterize the meteorological parameters and radiative transfer effects of the atmospheric boundary layer with surface observations or climatological values of temperature, pressure, and humidity (“climatology”). The LEEDR model is a fast-calculating, first-principles, worldwide surface-to-100-km, ultraviolet-to-radio-frequency (UV to RF) wavelength, atmospheric characterization package. In general, LEEDR defines the well-mixed atmospheric boundary layer with a worldwide, probabilistic surface climatology that is based on season and time of day and, then, computes the radiative transfer and propagation effects from the vertical profile of meteorological variables. The LEEDR user can also directly input surface observations. This research compares the LEEDR vertical profiles created from input surface observations or numerical weather prediction (NWP) data with the LEEDR climatological profile for the same time of day and season. The different profiles are compared with truth radiosonde data, and the differences from truth are found to be smaller for profiles created from surface observations and NWP than for those made from climatological data for the same season and time. In addition, this research validates LEEDR’s elevated aerosol extinction profile vertical structure against observed lidar measurements and details the advantages of using NWP data for atmospheric profile development. The impacts of these differences are demonstrated with a potential tactical high-energy-laser engagement simulation.
Measurement of plasma viscosity by free oscillation rheometry: imprecision, sample stability and establishment of a new reference range
Authors: Pedersen Lise , Nielsen Erling B , Christensen Majbrit K , Buchwald Maybritt , Nybo Mads 
Published: October 2013

Background Plasma viscosity (PV) is used in the investigation of hyperviscosity syndrome. We have evaluated the performance of a new bench-top free oscillation rheometer, ReoRox from Medirox, and established a new reference range. Methods Performance of the free oscillation rheometry (FOR) method was evaluated examining within-run and between-run imprecision, duration of measurement and operator simplicity. Furthermore, influence of storage on the PV measurements was assessed and a reference range based on plasma from 585 healthy men and women was established. Results Imprecision of the free oscillation rheometer was comparable to other viscometers and performance of the instrument was satisfying. The non-parametrical reference range established was 1.22–1.44 mPa s at 37℃ (2.5th and 97.5th percentiles). Conclusions We have established a FOR PV reference range to support clinical decision-making. Furthermore, we found high pre-analytical stability of the samples and an analytical imprecision comparable to other PV methods.
Goal Setting With Type 2 Diabetes
Authors: Fleming Susan E. , Boyd Angela , Ballejos Miriam , Kynast-Gales Susan A. , Malemute Charlene L. , Armstrong Shultz Jill , Vandermause Roxanne K. 
Published: October 2013

Purpose The purpose of this study was to explicate and interpret common experiences of diabetes educators (DEs) with patient goal setting for patients with type 2 diabetes in diabetes education. Methods Transcripts (n = 10) from semi-structured interviews were analyzed using a hermeneutic phenomenological approach to more deeply explore the accounts of DEs’ goal setting with patients with type 2 diabetes. Results The overarching pattern that emerged was “Striking a Balance,” which subsumed 4 subthemes: Applying Theoretical-Practical Principles When Setting Goals, Identifying Idealistic-Realistic Expectations, Creating Patient-Educator–Centered Plans, and Readying-Living With Goal Setting. The pattern, “Striking a Balance,” revealed a common meaning of DEs as experiences requiring balance and nuance in goal setting with patients. Implications The results of this study combined with the tenets of the self-determination theory can provide the DEs with real-life exemplars and a theoretical framework to encourage their patients to self-manage, increase intrinsic motivation, and improve adherence related to their lifestyle changes and glycemic control. DEs, as facilitators of change, can implement these changes with flexible and reciprocal activities with their patients. The DEs owned these activities and they are: “building the bond,” “sharing the session,” “readying for change,” “sending them home,” and “bringing them back.”
Black Feminist Me: Answering the Question ‘Who Do I Think I Am’
Authors: Dotson Kristie 
Published: October 2013

AbstractIn this paper, I offer a partial picture of my conceptual location as a US black feminist, professional philosopher and, by doing so, illustrate one of the ways Africana philosophy is being shaped and engaged. I offer a portrait of my conceptual location by identifying a value shared by some ‘anti-theory’ black feminists and some Africana professional philosophers in the US that ultimately recommends a consistent engagement in black feminist/philosophical praxis.
Serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal cell carcinoma
Authors: Pirinççi Necip , Kaba Mehmet , Geçit İlhan , Güneş Mustafa , Yüksel Mehmet Bilgehan , Tanık Serhat , Arslan Ayşe , Demir Halit 
Published: October 2013

Objectives: Prolidase is a member of the matrix metalloproteinase family. It plays a vital role in collagen turnover, matrix remodeling, and cell growth. Reactive oxygen species (ROS) have been implicated in the pathogenesis of various diseases, including cancers. Oxidative stress can cause tumor angiogenesis and may be carcinogenic. However, the relationship between antioxidant capacity and various cancers has been researched in several clinical trials. In our study, we aimed to identify serum prolidase activity, oxidative stress, and antioxidant enzyme levels in patients with renal tumors and to evaluate their relationships with each other. Materials and Methods: A total of 37 male patients with renal cell cancer and with a mean age of 56.28 ± 3.1 were included in the study. The control group comprising 36 male patients (mean age 56.31 ± 2.9) was randomly selected among the volunteers. Serum samples for measurement of superoxide dismutase (SOD), glutathione peroxidase (GSHPx), glutathione-S-transferase (GST), malondialdehyde (MDA), glutathione (GSH), and prolidase levels were kept at −20°C until they were used. Results: Serum prolidase activity and MDA levels were significantly higher in renal cancer patients than in controls (all, p < 0.05), while SOD, GSHPx, and GST levels were significantly lower ( p < 0.05). Conclusion: Our results indicate that increased prolidase seems to be related to increased oxidative stress along with decreased antioxidant levels in renal cancer.
Detecting Mood Disorder in Resource-Limited Primary Care Settings: Comparison of a self-administered screening tool to general practitioner assessment
Authors: Vöhringer Paul A , Jimenez Mirtha I , Igor Mirko A , Fores Gonzalo A , Correa Matias O , Sullivan Matthew C , Holtzman Niki S , Whitham Elizabeth A , Barroilhet Sergio A , Alvear Katherine , Logvinenko Tanya , Kent David M , Ghaemi Nassir S 
Published: October 2013

Objectives Although efficacious treatments for mood disorders are available in primary care, under-diagnosis is associated with under-treatment and poorer outcomes. This study compares the accuracy of self-administered screening tests with routine general practitioner (GP) assessment for detection of current mood disorder. Methods 197 consecutive patients attending primary care centres in Santiago, Chile enrolled in this cross-sectional study, filling out the Patients Health Questionnaire-9 (PHQ-9) for depression and the Mood Disorder Questionnaire (MDQ) for bipolar disorder, after routine GP assessment. Diagnostic accuracy of these self-administered tools was compared with GP assessment, with gold standard diagnosis established by a structured diagnostic interview with trained clinicians (SCID-I). Results The sample was 75% female, with a mean age of 48.5 (SD 16.8); 37% had a current mood disorder (positive SCID-I result for depression or bipolar disorder). Sensitivity of the screening instruments (SI) was substantially higher than GP assessment (SI: 0.8, [95% CI 0.71, 0.81], versus GP: 0.2, [95% CI 0.12, 0.25]: p-value < 0.0001), without sacrifice in specificity (SI: 0.9, [95% CI 0.86, 0.96], versus GP: 0.9, [95% CI 0.88, 0.97]: p-value = 0.7). This led to improvement in both positive predictive value (SI: 0.8, [95% CI 0.82, 0.90], versus GP: 0.6, [95% CI 0.50, 0.64]: p-value < 0.001) and negative predictive value (SI: 0.9, [95% CI 0.78, 0.91] versus GP: 0.7, [95% CI 0.56, 0.72]: p-value < 0.01). Conclusion Self-administered screening tools are more accurate than GP assessment in detecting current mood disorder in low-income primary care. Such screening tests may improve detection of current mood disorder if implemented in primary care settings.
High-Dose Neuroleptics and Neuroleptic Rotation for Agitated Delirium Near the End of Life
Authors: Bascom Paul B. , Bordley Jessica L. , Lawton Andrew J. 
Published: October 2013

Reason for the study: Agitated delirium presents unique challenges for hospice and palliative care clinicians. Haloperidol, the recommended neuroleptic, may be ineffective at low dose, or poorly tolerated at higher doses. Main Findings: This article reports on two patients with refractory agitated delirium. Both developed extrapyramidal symptoms from haloperidol and required rotation to an alternate neuroleptic. Patient #1 received 2000 mg/day oral chlorpromazine. Patient #2 received greater than 200 mg/day sublingual olanzapine. Control of agitation was achieved, though the doses were substantially higher than has previously reported in the literature. Each patient experienced considerable sedation, though this was an acceptable side effect for the family. Each patient was transferred from the acute care hospital to a location of family preference. There they died within a week of transfer. Conclusions: Agitated delirium is a palliative care emergency. High doses of neuroleptic medications, with rotation to an alternate neuroleptic when side effects occur with standard haloperidol, may effectively palliate agitated delirium. This remedy can provide the patient with a peaceful dying in a place of their choosing.
Serum analysis by 1H Nuclear Magnetic Resonance spectroscopy: a new tool for distinguishing neuromyelitis optica from multiple sclerosis
Authors: Moussallieh F-M , Elbayed K , Chanson JB , Rudolf G , Piotto M , De Seze J , Namer IJ 
Published: October 2013

Background: Neuromyelitis optica (NMO) and multiple sclerosis (MS), two inflammatory demyelinating diseases, are characterized by different therapeutic strategies. Currently, the only biological diagnostic tool available to distinguish NMO from MS is the specific serum autoantibody that targets aquaporin 4, but its sensitivity is low. Objective: To assess the diagnostic accuracy of metabolomic biomarker profiles in these two neurological conditions, compared to control patients. Methods: We acquired serum spectra (47 MS, 44 NMO and 42 controls) using proton nuclear magnetic resonance (1H-NMR) spectroscopy. We used multivariate pattern recognition analysis to identify disease-specific metabolic profiles. Results: The 1H-NMR spectroscopic analysis evidenced two metabolites, originating probably from astrocytes, scyllo-inositol and acetate, as promising serum biomarkers of MS and NMO, respectively. In 87.8% of MS patients, scyllo-inositol increased 0.15 to 3-fold, compared to controls and in 74.3% of NMO patients, acetate increased 0.4 to 7-fold, compared to controls. Using these two metabolites simultaneously, we can discriminate MS versus NMO patients (sensitivity, 94.3%; specificity, 90.2%). Conclusion: This study demonstrates the potential of 1H-NMR spectroscopy of serum as a novel, promising analytical tool to discriminate populations of patients affected by NMO or MS.