bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative methods for solving the problem of female infertility associated with endocrine disorders
Authors: Anvarova Sh. A. , Shukurov F. I. , Tulametova Sh. A. 
Published: August 2024

Aim: to analyze the publications assessing innovative methods of diagnostics and treatment used to solve the problem of female infertility associated with endocrine disorders.Materials and Methods. There was conducted a search for publications in electronic databases PubMed, Google Scholar, and eLibrary, which were selected in accordance with the PRISMA guidelines. All relevant articles published up to January 2024 were included in the review. As a result, 374 publications retrieved from PubMed, 147 – from eLibrary, and 33 – from Google Scholar were extracted. Duplicates and non-full-text versions of articles were excluded. After the selection procedure, 72 publications were included in the review.Results. During the data analysis, we identified key aspects providing deeper understanding of endocrine disorders affecting female infertility. In particular, new correlations were demonstrated between the level of select hormones and treatment success, as well as pathogenetic mechanisms were also identified influencing the conception and pregnancy process. These results will allow to develop more accurate diagnostic criteria and effective treatment methods able to increase women's chances of successful conception and pregnancy.Conclusion. The data analysis identified the hallmark aspects for diagnostics and treatment of female endocrine infertility, with new diagnostic criteria and effective treatment methods identified able to markedly improve outcomes. The crucial potential of the innovative approaches and methods considered contributes to improving reproductive health and increasing the chances of successful conception. We strongly encourage the introduction of such advanced technologies into clinical practice to optimize reproductive success.
Anaemia profile in hyperthyroid patients
Authors: Agarwal Shikha , Sablain Praveen , Siddiqui Mirajul , Shah Mural Manohar , Sharma Payal 
Published: August 2024

Thyroid disease is associated with anaemia is a frequent haemoglobin disorder. Hypothyroidism is a clinical syndrome that results from deficiency of the thyroid hormones, thyroxine (T) and triiodothyronine (T).The prevalence of subclinical hypothyroidism is higher, ranging from 4% to 10% of adults, with possibly a higher frequency in older women. Anaemia is a different types e.g. Iron deficiency anaemia, B12 deficiency anaemia, Sickle cell anaemia, Aplastic anaemia, haemolytic anaemias.Thyroid gland has a very important role in hemopoiesis. In thyroid patients blood disorder are frequently seen as it has role in metabolism of RBC and other blood components. Anaemia can occur when there is not enough oxygen to carry by RBC.This is a case control study which will be conducted in Rama medical college, hospital and department of Biochemistry in Hapur city (U.P). About 100 subjects will be enrolled in the current study including 50 patients with hypothyroidism and 50 with Healthy individual (controls) blood counts as control group. 2ml of EDTA anti coagulated blood and 3ml of whole blood will be taken from these subjects under fully aseptic condition (for CBC,TFT) respectively. EDTA Will be put on mixer instrument for mixing for 5min. CBC will be performed by coulter counter. The haematological parameters which will be studied include Hb, RBC, MCV, PCV. Iron profile (Iron, TIBC, Ferritin) level will be done by EM-200. The other 3ml of whole blood will be put in gel tube, serum will be prepared after centrifugation for 10 min, Thyroid function test including (T3, T4,TSH) based on ELISA.In this study, we found that T4 and TSH had significant statistical difference (&#60;0.05) between control and both hypothyroid and hyperthyroid groups as well as between hypothyroid and hyperthyroid groups. Erythrocyte sedimentation rate (ESR) and haematocrit showed significant statistical difference (p&#60;0.05) between control and both hypothyroid and hyperthyroid groups. Haemoglobin showed significant decrease in hypothyroid group when compared with controls.: In both people with hypothyroid and participants with hyperthyroid function, we found greater risks of anemia. Additionally, a decreased thyroid function at baseline indicated a tendency toward an elevated risk of anemia throughout follow-up. A randomized controlled research will be necessary to determine whether treating (subclinical) hypothyroidism reduces anemia.
A prospective study of clinical profile of premature rupture of membranes and its effect on maternal and perinatal outcome at term gestation in primigravida
Authors: Gopinath Sowmya , N Nuzrin Nazar , M H Bhavani , Gurumurthy Rekha 
Published: August 2024

Premature rupture of membranes (PROM) is defined as the spontaneous rupture of amniotic membranes with a release of amniotic fluid, before the onset of labor. If it occurs after 37 weeks of gestation, it is called as term PROM. The incidence of PROM worldwide varies between 5-10%.Out of which 80% occurs at term. In India, the incidence of PROM was reported as 7-12% in all labours.This study was a prospective, observational hospital based study which include the cases admitted to labour ward, Department of Obstetrics, District hospital, Tumakuru, Karnataka with Premature rupture of membranes or prelabor rupture of membranes (PROM) after fulfilling the inclusion and exclusion criteria. Out of 220 participants, about 60% (132) of subjects delivered vaginally and40%(88)of subjects underwent caesarean section. Among the 88 subjects who underwent caesarean section, the indications were fetal distress(34.09%), CPD(23%), failed induction (15.9%), non-progress of labour (23.86%). Among the study population, 10(4.54%) babies were with APGAR score &#60;7 and 210(95.45%) babies were with APGAR score ≥7. The Premature rupture of membranes at term still remains as one of the challenging situation to the practicing obstetrician. It is still an important cause of maternal and perinatal morbidity.
Efficacy of 2-chloroprocaine for spinal anesthesia compared to 0.5% hyperbaric bupivacaine: A randomized controlled study
Authors: Nallappagari Samuel , Gaddam Rukmini , Yerrathota Bhavishya , Rapaka Sri Archana 
Published: August 2024

In 1980s, nine cases of neurotoxicity were reported following the use of 2-chloroprocaine (2-CP). But, Taniguchi et al found that it was due to low pH and antioxidant sodium bisulfite. Further studies confirmed that it was safe to use the drug. It provides spinal anesthesia adequately.To study efficacy of 2-chloroprocaine for spinal anesthesia compared to 0.5% hyperbaric bupivacaineThis was a randomized controlled study. We used prospective double blind method. The study was done in 100 patients. Random allocation software was used to randomize patients in two groups. Group 1 patients (N=50) received 4 ml 1% 2-chloroprocaine while Group 2 patients (N=50) were given 2.5 ml 0.5% hyperbaric bupivacaine. Baseline parameters were similar in two groups (p&#62;0.05). Parameters like Sensory onset, Height of Sensory blockade, Time for two segment regression, Duration of motor block, Time to void urine were significantly more patients belonging to Group-II (0.5% hyperbaric bupivacaine) compared to patients belonging to group-I (2-chloroprocaine) (p&#60;0.05). 4 ml 1% 2-chloroprocaine for intrathecal injection of lower limb and lower abdominal surgeries is more effective than 2.5 ml 0.5% hyperbaric bupivacaine.
Bone marrow disease profile in geriatric patients: An institutional study
Authors: Thakur Shilpa , Anjum Afsana , Hans Deepa , Suri Jyotsna 
Published: August 2024

For the diagnosis and treatment of numerous hematological and non-hematological disorders in patients of all ages, a bone marrow examination is a crucial investigation. Due to the growing elderly population and the paucity of published studies on bone marrow disorders that only affect the elderly, age-related health conditions are becoming more prevalent. In our study, we enrolled elderly patients &#62;60 years old who had a bone marrow examination at GMC Jammu's pathology department.: To study the profile of various hematological and non-hematological lesions diagnosed on Bone Marrow aspiration and/or Trephine biopsy in Geriatric age group 2. To summarize an approach for evaluation of anemia in elderly patients for better management.: The study was conducted in two parts; a Retrospective study for 4 years and a prospective study of 1 year. It included all the patients &#62;60 years of age who had undergone Bone marrow examination in the hematology section of the Department of Pathology.: 200 bone marrow aspirations and 40 trephine biopsies, as well as peripheral blood smears and biopsy imprint smears, were all examined. Aplastic anemia, Megaloblastic anemia, Iron deficiency anemia, chronic disease-related anemia, and ITP were among the non-malignant hematological disorders that affected 50.5% (n=101) of the patients; various hematological malignancies affected 40.5% (n=81) of the patients; and non-hematological malignancies affected 1% (n=2) of the patients. 1% (n=2) of the cases were insufficient, and 7% (n=14) of the cases in which BMA and/or BMB were used for lymphoma staging and follow-up did not show any signs of marrow infiltration. With the growing elderly population in India, it is important to pay more attention to diagnosing and treating easily treatable conditions like anemia as well as enhancing the general health of geriatric patients the elderly, bone marrow aspiration.
Evaluation of serum cholesterol and serum albumin level as a risk factor for developing surgical site infections following elective surgery – A hospital based cross-sectional study
Authors: Sethy Sudarsan , Sucheta Panigrahi , Bhoi Kishan , Mohapatra Abinasha , Swain Pratik , Anisha Mettu 
Published: August 2024

Surgical site infections (SSI) are an important global public health problem and accounting for 22% of nosocomial infections. Globally surgical site infections (SSIs) lead to longer hospital stays and limiting the potential benefits of surgical interventions, increasing mortality risks and costs of patient.To determine if preoperative total cholesterol and serum albumin levels are associated with increased risk of surgical site infections and mortality.100 Cases were selected from the patients who got admitted to department of General Surgery, V.S.S. Medical College and hospital (VIMSAR), Burla for major elective surgery between November 2020 to October 2022. The study is an observational cross sectional study.Pre-operative serum albumin and serum cholesterol were estimated and any surgical site infection was noted following surgery. Association between serum albumin and serum cholesterol with SSI were evaluated by Chi-square test and independent sample T test using SPSS software.Out of 100 cases, 16 cases developed SSI. Most of the cases developing SSI had serum albumin level &#60; 3.5 g/dl. The surgical site infections (SSIs) rate decreased as serum albumin levels increased. Association of SSI decreased in malignancy as serum albumin levels improved. SSI were more seen in cases having serum cholesterol levels ≤ 159 mg/dl. Pre-operative evaluation of serum albumin and serum cholesterol should be done on a routine basis as nutritional assessment factors, so that SSI can be prevented by improving the albumin and cholesterol levels.
A study on thrombotic microangiopathy spectrum disorders in snake bite
Authors: S Vetrivel , S Abirami , R Charulatha 
Published: August 2024

Hemotoxic toxin syndrome, carry a high risk of hemorrhage and death. Snake venom have toxins that cause coagulopathy in a two different mechanism of actions. The snake toxins act as anticoagulant which inhibit clotting cascade or act as procoagulant toxins which activate the clotting cascade and consume clotting factors. The consumption coagulopathy in snake bite is referred to as Venom Induced Consumptive Coagulopathy (VICC). VICC is marked by prolonged clotting time and clotting factor deficiencies and an elevated d-dimer. VICC has a rapid onset and resolves with inactivation of toxins and synthesis of new clotting factors. A subset of VICC develops Thrombotic Microangiopathy (TMA). TMA is different and poorly understood hemotoxic syndrome.We performed a prospective analytical study of all consenting adult patients presenting to Thanjavur medical college, Tamil Nadu with suspected or with clear snake bite history within 24 hours and all Patients with thrombocytopenia less than 1.5 lakh in the first 3 days of hospital stay. All patients with Pre-existing kidney disease with serum creatinine more than 1.4 prior to snake bite and ultrasound evidence of chronic kidney disease were excluded. The study was done from January 2021 to January 2022.TMA spectrum disorders, including isolated thrombocytopenia, MAHA, and renal failure, are primarily hematological and renal, with severe presentations involving thrombocytopenia, MAH, schistiocytes, and renal failure. Clinicians should monitor tests, administer ASV early, and anticipate further TMA evidence to prevent complications.Thrombotic microangiopathy should be anticipated in all Hemotoxic snake bite. So early recognition and appropriate management will save the patient lives.
Perioperative management of patients recovered/recovering from COVID-19 infection with mucormycosis: A case series with practical recommendations
Authors: Singh Amandeep , Bawa Chashamjot Kaur , Dureja Mehak , Raina Jyoti 
Published: August 2024

Mucormycosis as a secondary fungal invasion in COVID-19 patients has been described in individual reports worldwide. However, India has declared mucormycosis epidemic in four states and one union territory. The sudden plethora of rhino-orbital mucormycosis cases in India has put the medical faculty to ponder over etiology behind such peaking graph of cases while braving it out trying to save these patients. As anaesthesiologists, the peri-operative management of these cases is a challenge due to known usual and unusual as well as yet unknown long-term multi-system derangements found in COVID-19 illness in addition to the serious nature of this aggressive fungal invasion. We are presenting a case series of six patients who underwent Functional Endoscopic Sinus Surgery along with orbital exenteration for mucormycosis. Key Messages: Peri-operative management of mucormycosis in COVID-19 patients requires multidisciplinary evaluations, cardio-pulmonary optimisation and tight blood sugar control for better outcome. The ulterior goal should be avoiding exacerbation of post-COVID sequalae as well as extensive debridements along with Amphotericin b therapy to prevent further mocormycosis invasion.
Sintesis dan Karakterisasi NiFe2O4 Sebagai Adsorben Amonia dalam Air Akuarium Budidaya Ikan Mas (Cyprinus carpio)
Authors: Murtadha Fadhil Hisyam , Erdawati Erdawati , Setiawan Jan 
Published: August 2024

Abstrak
Nikel ferit (NiFe2O4) termasuk adsorben magnetik yang baik untuk polutan organik dan anorganik. Penelitian ini bertujuan untuk mengetahui kemampuan nikel ferit dalam mengadsorpsi amonia dalam air akuarium budidaya ikan mas (Cyprinus carpio). Nikel ferit disintesis dengan menggunakan metode hidrotermal. Pola difraksi XRD dan spektrum FTIR mengonfirmasi terbentuknya senyawa NiFe2O4. Hasil karakterisasi SAA menunjukkan NiFe2O4 memiliki tipe isoterm adsorpsi tipe IV (mesopori), dengan luas permukaan Brunauer Emmet Teller (BET) sebesar 18,6431 m²/g. Hasil karakterisasi SEM menunjukkan bentuk morfologi dari NiFe2O4 adalah bulat dan homogen. Data EDX menunjukkan bahwa unsur Ni, Fe dan O sebagai komponen penyusun utama bagi NiFe2O4. Nikel ferit hasil sintesis digunakan sebagai adsorben NH3 dalam air akuarium dan mampu mengadsorpsi NH3 sebesar 0,26 mg/L dengan efisiensi 96% dalam waktu 3 jam. Model kinetika yang sesuai untuk adsorpsi NH3 dalam air akuarium terhadap NiFe2O4 adalah model kinetika orde kedua semu dengan nilai koefisien determinasi (R2 = 0,9835), yang menunjukkan bahwa proses adsorpsi antara NH3 dalam air akuarium dengan NiFe2O4 adalah adsorpsi secara kimia
Kata-kata kunci: adsorben magnetik, amonia, nikel ferit (NiFe2O4)
Abstract
Nickel ferrite (NiFe2O4) is one of the good magnetic adsorbents for organic and inorganic pollutants. The aim of this study is to find out the ability of nickel ferrite to adsorb ammonia in aquarium water for goldfish (Cyprinus carpio) cultivation. Nickel ferrite was synthesized using hydrothermal method. XRD diffraction pattern and FTIR spectra confirmed the formation of NiFe2O4 compounds. The results of SAA characterization showed that NiFe2O4 has adsorption isotherm type-IV (mesoporous), with the surface area of ​​Brunauer Emmet Teller (BET) 18.6431 m²/g. The results of SEM characterization show that the morfology form of NiFe2O4 are spherical and homogeneous. EDX data showed that Ni, Fe and O as the main component for NiFe2O4. The synthesized nickel ferrite was then used as NH3 adsorbent in aquarium water and able to adsorb NH3 equal to 0.26 mg/L with efficiency 96% in 3 hours. Kinetics model suitable for the adsorption NH3 in aquarium water toward NiFe2O4 is a pseudo-second-order with the value of determination coefficient is (R2 = 0.9835), which shows that the adsorption process between NH3 in aquarium water and NiFe2O4 is chemisorption.
Keywords: Amonia, Magnetic adsorbent, Nickel ferrite (NiFe2O4)
The Protective Role of Nigela Sativa Volatile Oil on Antioxidant and Oxidative Stress Enzymes
Authors: Ahmed Ahmed Tawfeeq , Hameed Inas Hazim , Hameed Walaa Hazim 
Published: August 2024

Hepatotoxicity is the outcome of a paracetamol overdose.In this study, 40 adult male rats, weighing 180–260 gm and aged between 9 and 13 weeks, were given doses of Nigela sativa oil and their liver enzymes were examined to see how paracetamol affected them. The rats were kept in an environment at a temperature of 25 Co in an animal house. ,There were four groups of rats, and food was provided for them. (G). (G1) The only injections given to the control group are food and regular saline (0.9% of the time). (G2) 200 mg/kg of N. sativa and (G3) 400 mg/kg of paracetamol Addition of 400 mg/kg body weight of paracetamol. supplying 300 mg/kg B.W. of N. sativa to (G4)400 milligrams/kg B.W. of aspirin. Rat G2, GPT 87.80 IUL, and GOT hepatic enzyme concentration (129.32 IUL) all exhibit significant increases in comparison to the control. Furthermore, the levels of the liver GSH enzyme in rats (G2 )1.24 IUL shown a substantial increase, whereas G3 ( GOT ) 91.9 IUL, (GPT )76.70 IUL, and group (G4) GOT 109.88 IUL and enzyme (GPT ) 55.66 IUL exhibited significant declines as compared with control. While MDA enzyme in rats G2 (0.259 IUL) shows a major increase in comparison to the control, rats G3 (0.139 IUL) and G4 (0.112) show a noticeable decrease in comparison to G2. While body weight indicates that G2's outcomes are significantly lower than those of the other three groups. Groups G3 (2.55 gm) and G4 (2.7 gm) demonstrated a significant rise in liver weight compared to controls and G2, whereas groups G2 (24.23 gm) demonstrated a significant increase in liver weight compared to controls and group G2. Male rats in groups G2 (1.7 gm) demonstrated a significant drop in liver weight compared to controls.
What information do people want to know about hijamah?
Authors: Rahmadi Agus Rahmadi 
Published: August 2024

The purpouse of the reseaech is to explore community knowledge about cupping and identify the scope of information which is eiger to find out by community about cupping. This research uses qualitative method with phenomenological approach. The subjects of the research is the peoplewho have and have not cupping. Data collection was carried out through detail interviews using interview guidance. The research was conductedfrom May-June 2017 at PKM Tarumajaya, Clinic and RB Umi Rahma and Bekasi District Hospital. Sample is done by purposive sampling.The number of participants who get involved is 17 participants. Discussions in this study research include community knowledge,false views about cupping, cupping skepticism, and information which is eager to find out about cupping. These include the history of cupping,the edge of doing cupping, time for doing cupping, the point location of cupping, cupping indication, cupping contraindications, the equipment of cupping,the way of doing cupping, the procedure of cupping, the position of doing cupping, the weakness of cupping, the effects of cupping, the evaluationof cupping, the protection of cupping, the implemtentation of cupping, the security of cupping, formal implementation of cupping, cupping duringfasting, Cupping versus medical treatment, cupping versus traditional medicine. The lack of public knowledge about cupping tends to lead tothe stigmatization of cupping. It is advised to the government to make special rules of cupping and for service providers cupping in order tobetter promote cupping as a safe alternative treatment to the community.
Pemanfaatan Ekstrak Tanaman Ciplukan (Physalis Angulat L.) sebagai Terapi Anemia pada Remaja di Masa Menstruasi
Authors: Yunita Emi , Apidianti Sari Pratiwi 
Published: August 2024

Anemia is often associated with conditions of weakness, fatigue, lethargy due to lack of iron in the blood. Not only in adults, children and even toddlers can be affected by anemia. A survey shows that anemia is higher affected to women than men. If anemia occurs in a girl, the effect is not only on the child but also to the next generation. This research is an experimental analytic research, a study based on the level of neutrality place of research to survey research and naturalistic (qualitative). In essence, the experimental research is examining the effect of treatment on behavior that arises as a result of treatment. This study aims to determine the use of Ciplukan extract to increase the iron in the blood, whether it has influences to the increase in hemoglobin levels, so that it can be used as a therapy for anemia That has experienced by adolescence during menstruasion. In addition, the study also obtained information on how to reduce the intensity of menstrual pain by using non-pharmacological techniques, namely by consuming of Ciplukan extract.
Hubungan Inisiasi Menyusui Dini dengan Kestabilan Suhu Tubuh pada Bayi Baru Lahir di RS Muhammadiyah Gresik Kabupaten Gresik
Authors: Ernawati Ernawati , Nuraini Nanik 
Published: August 2024

The problem discussed in this scientific paper is the relationship between the initiation of Early Breastfeeding and the stability of the newborn's body temperature, the aim is to find out the relationship of the initiation of Early Breastfeeding with the stability of the body temperature of the newborn. The purpose of this study is the relationship between Early Breastfeeding Initiation and Body Temperature Stability in Newborns at Muhammadiyah Hospital Gresik, Gresik Regency. In this study using a case control approach. The population in this study were 39 newborns in Muhammadiyah Hospital Gresik, Gresik Regency. The study sample was 20 newborns at Muhammadiyah Hospital Gresik taken from the population by determining the sample size using the Slovin formula. The design of this study used a case-control design. Cases were taken from infants that received IMD while controls were newborns who had normal body temperature. Techniques data collection through interviews and observations to obtain primary data, while secondary data are obtained by tracking the patient's medical record documents. Data processing techniques follow the steps : editing, coding, data entry, tabulation, and scoring. While the data analysis used the Chi Square test. The results of the bivariate analysis showed that the value of X2hit (10,588)> X2 table (3.8415) or p-value (0.009) <alpha (0.05). Based on these results the null hypothesis (Ho) is rejected. The alternative hypothesis (Ha) is accepted, meaning that there is a relationship between the initiation of early breastfeeding and the stability of body temperature in newborns at Muhammadiyah Hospital Gresik.