bluuebunny/crossref_metadata_2025_split huggingface dataset:
IMPLEMENTASI KEBIJAKAN KAWASAN RAMAH LANSIA DI KABUPATEN DHARMASRAYA, PROVINSI SUMATERA BARAT
Authors: Pazka M Iqbal Sarabayan , Ariany Ria , Aromatica Desna 
Published: August 2024

The high number of elderly people, namely 7.01%, is the basis for the Dharmasraya Regency Government to make the elderly one of the regional problems that must be resolved. Based on the guidelines issued by the Central Government through the Ministry of Social Affairs, Dharmasraya Regency issued an Elderly Area Policy through the 2020-2024 Regional Medium Term Development Plan. This research aims to describe and analyze the Implementation of the Elderly Dharmasraya Regency Policy. This research uses Edward III's theory 4 variables to determine the success of implementing a policy: communication, resources, disposition, and bureaucratic structure. The research results show that characteristics within agencies, a clear division of tasks and responsibilities, and good coordination between agencies are key factors for success. Despite the government's commitment to providing adequate funding, there are still potential problems in allocating and using funds that are not on target due to a lack of supervision and monitoring. So, concrete steps need to be taken to improve coordination and ensure that all parties involved have effective communication channels. Tingginya jumlah angka penduduk lanjut usia di Kabupaten Dharmasraya yakni sebesar 7,01%, menjadi dasar bagi pemerintah untuk menjadikan persoalan lansia sebagai salah satu permasalahan daerah yang harus di prioritaskan. Berdasarkan pedoman yang dikeluarkan oleh pemerintah pusat melalui kementerian sosial, Pemerintah Kabupaten Dharmasraya kemudian mengeluarkan Kebijakan mengenai Kawasan Ramah lansia melalui Rencana Pembangunan Jangka Menangah Daerah pada Tahun 2020-2024. Tujuan penelitian ini untuk mendeskripsikan dan menganalisis Implementasi Kebijakan Kabupaten Dharmasraya terkait kebijakan Kawasan Ramah Lansia tersebut. Penelitian ini menggunakan metode penelitian kualitatif deskriptif dengan berlandaskan teori Edward III. Terdapat 4 variabel yang menentukan keberhasilan implementasi suatu kebijakan, yaitu komunikasi, sumberdaya, disposisi dan struktur birokrasi. Hasil penelitian kemudian menunjukkan bahwa karakteristik dalam badan-badan, pembagian tugas dan tanggung jawab yang jelas, serta koordinasi yang baik antar badan-badan menjadi faktor kunci untuk mencapai keberhasilan implementasi kebijakan. Meskipun ada komitmen pemerintah untuk menyediakan pendanaan yang mencukupi, masih terdapat potensi masalah dalam alokasi dan penggunaan dana yang tidak tepat sasaran karena kurangnya pengawasan dan monitoring. Maka perlu ada langkah-langkah konkret untuk memperbaiki koordinasi dan memastikan bahwa semua pihak terlibat memiliki saluran komunikasi yang efektif.
Uji pupuk silika terhadap intensitas serangan hama penggerek batang (Chilo influscatellus) dan pucuk (Scirpophaga excerptalis) pada tebu (Saccharum officinarum L.) varietas Bululawang
Authors: Istiqomah  , Asbani Nur , Zayadi Hasan , Tito Sama Iradat 
Published: August 2024

Sugarcane (Saccharum officinarum L.) is the main ingredient in the manufacture of sugar where sugar is a primary need for the community. At this time sugarcane plants declined due to the attack of stem borer (Chilo influscatellus) and shoots (Scirpophaga excerptalis), resulting in production losses. Silica plays an important role in helping to reduce pest attacks, thereby accelerating the growth of sugarcane plants. This study aimed to determine the effect of silica on the intensity of attack by stem borer and shoots. This research was conducted in the BALITAS experimental garden using RAK treatment which in this study used Silica Simax, Forsil, Bality and Control. Where after the data results were obtained, they were analyzed using the Two-way ANOVA test using SPSS. The results obtained on stem borer and shoots before silica treatment increased the attack of the borer and after treatment with silica the borer was reduced so that silica was effective in treating stem borer (Chilo influscatellus) and shoots. (Scirpophaga excerptalis) sugarcane. Silica is also able to accelerate the growth of sugarcane plants, photosynthesis and resistance to external attacks.
Keywords: Borer, Silica (Si), Sugarcane (Saccharum officinarum L), Buluawang variety.
ABSTRAK
Tanaman tebu (Saccharum officinarum L.) merupakan bahan utama dalam pembuatan gula yang mana gula merupakan kebutuhan primer bagi masyarakat. Pada saat ini tanaman tebu menurun karena adanya serangan hama penggerek batang (Chilo influscatellus) dan pucuk (Scirpophaga excerptalis), berdampak pada kerugian produksinya. Silika berperan penting untuk membantu mengurangi serangan hama, sehingga mempercepat pertumbuhan tanaman tebu. Penelitian ini bertujuan untuk mengetahui pengaruh silika terhadap intensitas serangan hama penggerek batang (Chilo influscatellus) dan pucuk (Scirpophaga excerptalis). Penelitian ini dilakukan dikebun percobaan BALITAS dengan menggunakan perlakukan RAK yang mana pada penelitian ini menggunakan Silika Simax, Forsil, Balitas dan Kontrol. Dimana setelah didapatkan hasil data lalu di analisis dengan menggunakan uji Two-way ANOVA menggunkaan SPSS. Hasil yang didapatkan pada hama penggerek batang (Chilo influscatellus) dan pucuk (Scirpophaga excerptalis) sebelum dilakukan perlakuan silika serangan hama penggerek tersebut meningkat dan setelah dilakukan perlakuan silika hama penggerek berkurang sehingga silika efektif untuk melakukan perlakuan terhadap hama penggerek batang (Chilo influscatellus) dan pucuk (Scirpophaga excerptalis) tebu. Silika juga mampu mempercepat pertumbuhan tanaman tebu, fotosintesis dan ketahanan serangan dari luar.
Kata kunci: hama penggerek, Silikas (Si), Tebu (Saccharum officinarum L), varietas Buluawang.
A robust multimodal detection system: physical exercise monitoring in long-term care environments
Authors: Al Mudawi Naif , Batool Mouazma , Alazeb Abdulwahab , Alqahtani Yahay , Almujally Nouf Abdullah , Algarni Asaad , Jalal Ahmad , Liu Hui 
Published: August 2024

IntroductionFalls are a major cause of accidents that can lead to serious injuries, especially among geriatric populations worldwide. Ensuring constant supervision in hospitals or smart environments while maintaining comfort and privacy is practically impossible. Therefore, fall detection has become a significant area of research, particularly with the use of multimodal sensors. The lack of efficient techniques for automatic fall detection hampers the creation of effective preventative tools capable of identifying falls during physical exercise in long-term care environments. The primary goal of this article is to examine the benefits of using multimodal sensors to enhance the precision of fall detection systems.MethodsThe proposed paper combines time–frequency features of inertial sensors with skeleton-based modeling of depth sensors to extract features. These multimodal sensors are then integrated using a fusion technique. Optimization and a modified K-Ary classifier are subsequently applied to the resultant fused data.ResultsThe suggested model achieved an accuracy of 97.97% on the UP-Fall Detection dataset and 97.89% on the UR-Fall Detection dataset.DiscussionThis indicates that the proposed model outperforms state-of-the-art classification results. Additionally, the proposed model can be utilized as an IoT-based solution, effectively promoting the development of tools to prevent fall-related injuries.
CRISPR-Cas9 screening develops an epigenetic and transcriptional gene signature for risk stratification and target prediction in neuroblastoma
Authors: Zhang Liaoran , Mo Jialin , Shi Hao , Xiong Jing , Aierken Yeerfan , Chen Feng , Tang Yujie , Zhao Kewen , Lv Zhibao , Tan Kezhe 
Published: August 2024

Objectives: Neuroblastoma (NB), a pediatric malignancy of the peripheral nervous system, is characterized by epigenetic and transcriptional (EP-TF) anomalies. This study aimed to develop an EP-TF clinical prognostic model for NB using CRISPR-Cas9 knockout screening.Results: An integrative analysis was conducted using CRISPR-Cas9 screening in vitro and in vivo with public NB datasets to identify 35 EP-TF genes that exhibited the highest expression in NB and were highly dependent on cancer viability. After univariate analysis, 27 of these 35 genes were included in the least absolute shrinkage and selection operator screen. We established and biologically validated a prognostic EP-TF model encompassing RUVBL1, LARP7, GTF3C4, THAP10, SUPT16H, TIGD1, SUV39H2, TAF1A, SMAD9, and FEM1B across diverse NB cohorts. MYCN serves a potential upstream regulator of EP-TF genes. The high-risk subtype exhibited traits associated with the malignant cell cycle, MYCN-linked signaling and chromatin remodeling, all of which are correlated with poor prognosis and immunosuppression. MEK inhibitors have emerged as promising therapeutic agents for targeting most EP-TF risk genes in NB.Conclusion: Our novel prognostic model shows significant potential for predicting and evaluating the overall survival of NB patients, offering insights into therapeutic targets.
Gut microbiota, circulating inflammatory proteins and sepsis: a bi-directional Mendelian randomization study
Authors: Li Zuming , Lin Liangcai , Kong Yunqi , Feng Jieni , Ren Xiaolei , Wang Yushi , Chen Xueru , Wu Siyi , Yang Rongyuan , Li Jiqiang , Liu Yuntao , Lu Yue , Chen Jiankun 
Published: August 2024

BackgroundGut microbiota is closely related to the occurrence and development of sepsis. However, the causal effects between the gut microbiota and sepsis, and whether circulating inflammatory proteins act as mediators, remain unclear.MethodsGut microbiota, circulating inflammatory proteins, and four sepsis-related outcomes were identified from large-scale genome wide association studies (GWAS) summary data. Inverse Variance Weighted (IVW) was the primary statistical method. Additionally, we investigated whether circulating inflammatory proteins play a mediating role in the pathway from gut microbiota to the four sepsis-related outcomes.ResultsThere were 14 positive and 15 negative causal effects between genetic liability in the gut microbiota and four sepsis-related outcomes. Additionally, eight positive and four negative causal effects were observed between circulating inflammatory proteins and the four sepsis-related outcomes. Circulating inflammatory proteins do not act as mediators.ConclusionsGut microbiota and circulating inflammatory proteins were causally associated with the four sepsis-related outcomes. However, circulating inflammatory proteins did not appear to mediate the pathway from gut microbiota to the four sepsis-related outcomes.
A high functional cure rate was induced by pegylated interferon alpha-2b treatment in postpartum hepatitis B e antigen-negative women with chronic hepatitis B virus infection: an exploratory study
Authors: Zhong Wenting , Yan Lanzhi , Zhu Yage , Shi Lei , He Yingli , Chen Tianyan , Zheng Jie 
Published: August 2024

Background and aimsLimited data have been reported on achieving functional cure using pegylated interferon (Peg-IFN) alpha-2b treatment for postpartum hepatitis B e antigen (HBeAg)-negative women with chronic hepatitis B virus (HBV) infection. This study was to assess the effectiveness and safety of Peg-IFN alpha-2b in HBV postpartum women without HBeAg and identify factors linked to the functional cure.MethodsA total of 150 HBeAg-negative postpartum women were retrospectively recruited.47 patients received Peg-IFN alpha-2b [Peg-IFN(+) group] and 103 patients did not [Peg-IFN(-) group]. Propensity score matching (PSM) was used to adjust the baseline imbalance between the two groups. The patients were followed for at least 48 weeks. The primary endpoints were hepatitis B surface antigen(HBsAg) loss and HBsAg seroconversion at 48 weeks. Logistic regression analysis was used to assess factors associated with HBsAg loss at 48 weeks.ResultsAt week 48,the HBsAg loss and seroconversion rate in Peg-IFN(+) group were 51.06%(24/47) and 40.43%(19/47), respectively. Even after PSM, Peg-IFN(+) group still showed higher HBsAg loss rate (50.00% vs 7.14%,p&lt;0.001) and higher HBsAg seroconversion rate (38.10% vs 2.38%,p&lt;0.001). Baseline HBsAg levels (Odds Ratio [OR]: 0.051, 95% Confidence Interval [CI]: 0.003-0.273, P=0.010), HBsAg at week 24 (OR:0.214, 95%CI:0.033-0.616, P=0.022), HBsAg decline at week 24 (OR:4.682, 95%CI: 1.624-30.198, P=0.022) and postpartum flare (OR:21.181, 95%CI:1.872-633.801, P=0.030) were significantly associated with HBsAg loss at week 48 after Peg-IFN alpha-2b therapy. Furthermore, the receiver operating characteristic curve (ROC) showed that the use of baseline HBsAg&lt;182 IU/mL, HBsAg at week24 &lt; 4 IU/mL and HBsAg decline at week24&gt;12IU/mL were good predictors of HBsAg loss. No serious adverse events were reported.ConclusionPeg-IFN alpha-2b treatment could achieve a high rate of HBsAg loss and seroconversion in HBeAg-negative postpartum women with reliable safety, particularly for patients experience postpartum flare and have low baseline HBsAg levels.
Case Report: Epi-endocardial bridges in refractory cavotricuspid isthmus-dependent atrial flutter: technical analysis of epi-endocardial breakthrough
Authors: Matteucci Andrea , Pandozi Claudio , Russo Maurizio , Galeazzi Marco , Lombardi Enrico , Mariani Marco Valerio , Lavalle Carlo , Colivicchi Furio 
Published: August 2024

BackgroundTypical isthmus-dependent atrial flutter (AFL) is traditionally treated through radiofrequency (RF) ablation to create a bidirectional conduction block across the cavo-tricuspid isthmus (CTI) in the right atrium. While this approach is successful in many cases, certain anatomical variations can present challenges, making CTI ablation difficult.MethodsWe enrolled four patients with typical counter-clockwise AFL who displayed an epicardial bridge at the CTI. Patients underwent high-resolution mapping of the right atrium and CTI ablation.ResultsPost-mapping identified areas of early focal activation outside the lesion line which suggested the presence of an epi-endocardial bridge with an endocardial breakthrough, confirmed by recording a unipolar rS pattern on electrograms at that site. A stable CTI block was achieved in all patients only after ablation at the site of the epi-endocardial breakthrough.ConclusionsThe presence of an epicardial bridge at the CTI, allowing conduction to persist despite endocardial ablation, should be considered in challenging cases of CTI-dependent AFL. Understanding this phenomenon and utilizing appropriate mapping and ablation techniques are essential for achieving successful and lasting CTI block.
Analyzing the barriers and enablers to internet hospital implementation: a qualitative study of a tertiary hospital using TDF and COM-B framework
Authors: Wu Xiaolong , Kuang Yulin , Guo Yonglin , Wei Ning , Fan Zichun , Ling Jingru 
Published: August 2024

BackgroundInternet hospitals have become an important way to improve the accessibility of medical services and promote medical equity in China. However, there is still lack of research on the behavior of medical personnel during the process of using Internet medical services, and the elements of behavior that motivate doctors to actively use or resist the use of Internet hospitals are still not fully analyzed. The study applied the Theoretical Domains Framework to examine the factors affecting the engagement of medical personnel in Internet hospitals, with the aim of guiding the design of intervention to enhance Internet hospital participation.MethodsThis study utilized qualitative analysis. Semi-structured questionnaires based on the Theoretical Domains Framework (TDF) and Capability-Opportunity-Motivation-Behavior (COM-B) model was developed and administered to 40 doctors and nurses at a Grade A tertiary hospital in Guangdong Province. Data was coded and analyzed using qualitative methods including Nvivo software.ResultsThe research displayed 19 barriers and 7 enablers for the implementation of Internet hospitals, all 14 TDF domains impacted participation with motivation cited most frequently. Despite challenges, medical personnel exhibited a generally optimistic stance towards utilization of the Internet hospital. Major barriers include the higher requirement of diagnostic ability, objective difficulties brought by online consultation to the decision-making process, limitation of time and other resources, not ideal technological and institutional environment, lack of self-efficacy and negative expectation of results in online consultation. Key enablers include patient needs and the positive impact of online care on the medical process and patient experience.DiscussionThis qualitative study identified a range of barriers and enablers to Internet hospital participation according to medical personnel, providing an conceptual framework to guide further research evaluating implementation strategies. Expanded research and targeted interventions design can help optimize participation in this evolving healthcare delivery model.
Long-term efficacy of lobectomy for stage T1 papillary thyroid carcinoma with varying degrees of lymph node metastasis
Authors: Qin Chao , Cai Sijia , Qi Yanyu , Liu Meilin , Xu Weibo , Yin Min , Tang Haitao , Ji Qinghai , Liao Tian , Wang Yu 
Published: August 2024

BackgroundThe presence of lymph node metastasis (LNM) is frequently observed in papillary thyroid carcinoma (PTC), and most clinical guidelines recommend total thyroidectomy. However, the impact of LNM on specific types of locoregional recurrence remains uncertain, particularly for stage T1 PTC.MethodsThe present retrospective cohort study enrolled patients diagnosed with stage T1 PTC between 2008 and 2015. Propensity score matching was performed in patients with lobectomy accompanied by varying degrees of LNM. Logistic regression analysis was performed to compare the effect of LNM on relapse types, and Kaplan-Meier method was utilized to calculate recurrence-free survival.ResultsThe study cohort comprised 2,785 patients who were followed up for an average duration of 69 months. After controlling follow-up time and potential prognostic factors, we include a total of 362 patients in each group. Recurrence rates in the N0, N1a, and N1b groups were found to be 2.5%, 9.7%, and 10.2% respectively. Notably, group N1a versus group N0 (P=0.803), N1b group versus N0 group (P=0.465), and group N1b versus group N1a (P=0.344) had no difference in residual thyroid recurrence. However, when considering lymph node recurrence, both N1a(P=0.003) and N1b(P=0.009) groups showed a higher risk than N0 group. In addition, there was no difference in lymph node recurrence between N1b group and N1a group (P=0.364), but positive lymph node (PLN) and lymph node positive rate (LNPR) demonstrated a strong discriminatory effect (P&lt;0.001).ConclusionLobectomy may be more appropriate for patients with unilateral stage T1 PTC in the low LNPR group.
Unveiling potential drug targets for lung squamous cell carcinoma through the integration of druggable genome and genome-wide association data
Authors: Wu Wenhua , Chen Zhengrui , Wen Haiteng , Zhang Haiyun 
Published: August 2024

Background: Lung squamous cell carcinoma (LSCC) is a major subtype of lung cancer with poor prognosis and low survival rate. Compared with lung adenocarcinoma, yet no FDA-approved targeted-therapy has been found for lung squamous cell carcinoma.Methods: To identify potential drug targets for LSCC, Summary-data-based Mendelian randomization (SMR) analysis was used to examine the potential association between 4,543 druggable genes and LSCC, followed by colocalization analysis and HEIDI tests to confirm the robustness of the result. Phenome-wide association study (PheWAS) explored potential side effects of candidate drug targets. Enrichment analysis and protein-protein interaction networks revealed the function and significance of therapeutic targets. Single-cell expression analysis was used to examine cell types with enrichment expression of druggable genes in LSCC tissue. Drug prediction included screening potential drug candidates and evaluating their interactions with targets through molecular docking.Results: This research has identified ten significant drug targets for LSCC through a comprehensive SMR analysis. These targets included (COPA, PKD2L1, CCR1, C2, CYP21A2, and NCSTN as risk factors, and CCNA2, C4A, APOM, and LPAR2 as protective factors). PheWAS demonstrated that C2, CCNA2, LPAR2, and NCSTN exhibited associations with other phenotypes at the genetic level. Then, we found four potentially effective drugs with the Dsigdb database. Subsequently, molecular docking indicated that favorable binding interactions between drug candidates and potential target molecules. In the druggability evaluation, five out of ten drug target genes have been used in drug development (APOM, C4A, CCNA2, COPA, and PKD2L1). Six out of ten druggable genes showed significant expression in LSCC tissues (COPA, PKD2L1, CCR1, C2, NCSTN, LPAR2). Besides, Single-cell expression analysis revealed that C2 and CCNA2 were primarily enriched in macrophages, while COPA and NCSTN were enriched in both macrophages and epithelial cells.Conclusion: Our research revealed ten potential druggable genes for LSCC treatment, which might help to advance the precise and efficient therapeutic approaches of LSCC.
Unveiling the bioinformatic genes and their involved regulatory mechanisms in type 2 diabetes combined with osteoarthritis
Authors: Mao Guangming , Xu Wenhao , Wan Lingli , Wang Hongpin , Xu Shutao , Zhang Liangming , Li Shiyang , Zhang Jifa , Lai Zhongming , Lan Yuping , Liu Jianhui 
Published: August 2024

BackgroundType 2 Diabetes Mellitus (T2D) and Osteoarthritis (OA) are both prevalent diseases that significantly impact the health of patients. Increasing evidence suggests that there is a big correlation between T2D and OA, but the molecular mechanisms remain elusive. The aims of this study are to investigate the shared biomarkers and potential molecular mechanisms in T2D combined with OA.MethodsT2D and OA-related differentially expressed genes (DEGs) were identified via bioinformatic analysis on Gene Expression Omnibus (GEO) datasets GSE26168 and GSE114007 respectively. Subsequently, extensive target prediction and network analysis were finished with Gene Ontology (GO), protein-protein interaction (PPI), and pathway enrichment with DEGs. The transcription factors (TFs) and miRNAs coupled in co-expressed DEGs involved in T2D and OA were predicted as well. The key genes expressed both in the clinical tissues of T2D and OA were detected with western blot and qRT-PCR assay. Finally, the most promising candidate compounds were predicted with the Drug-Gene Interaction Database (DGIdb) and molecular docking.ResultsIn this study, 209 shared DEGs between T2D and OA were identified. Functional analysis disclosed that these DEGs are predominantly related to ossification, regulation of leukocyte migration, extracellular matrix (ECM) structural constituents, PI3K/AKT, and Wnt signaling pathways. Further analysis via Protein-Protein Interaction (PPI) analysis and validation with external datasets emphasized MMP9 and ANGPTL4 as crucial genes in both T2D and OA. Our findings were validated through qRT-PCR and Western blot analyses, which indicated high expression levels of these pivotal genes in T2D, OA, and T2D combined with OA cases. Additionally, the analysis of Transcription Factors (TFs)-miRNA interactions identified 7 TFs and one miRNA that jointly regulate these important genes. The Receiver Operating characteristic (ROC) analysis demonstrated the significant diagnostic potential of MMP9 and ANGPTL4.Moreover, we identified raloxifene, ezetimibe, and S-3304 as promising agents for patients with both T2D and OA.ConclusionThis study uncovers the shared signaling pathways, biomarkers, potential therapeutics, and diagnostic models for individuals suffering from both T2D and OA. These findings not only present novel perspectives on the complex interplay between T2D and OA but also hold significant promise for improving the clinical management and prognosis of patients with this concurrent condition.