bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Post‐kala‐azar Dermal Leishmaniasis
Authors: Ono Hiroko , Ghoreishi Meiran , Yokozeki Hiroo , Katayama Ichiro , Nishioka Kiyoshi 
Published: April 2015

AbstractOnly a few cases of Post‐kala‐azar dermal leishmaniasis have been reported in Japan, especially recently. We describe a case of a 32‐year‐old woman who developed rose‐colored nodules on her forearms two years after Kala‐azar. A skin biopsy specimen from a nodule revealed not only granulomatous changes but also many amastigotes of Leishmania donovani in macrophages. Rose‐colored nodules were also distributed on her face and neck. Treatment with antimony compound was very effective.
The Vascular Space‐like Structure in Melanocytic Nevus Is Not an Injection Artifact: Report of a Case and an Experimental Study
Authors: Demitsu Toshio , Kakurai Maki , Yamada Tomoko , Kiyosawa Tomoharu , Yaoita Hideo 
Published: April 2015

AbstractMelanocytic nevi may microscopically associate with clefts or slits of the nests resembling lymphatic or vascular spaces. This unique histologic feature has been known as an artifact of injection or tissue‐processing. We present a case of melanocytic nevus with a prominent vascular space‐like structure. We also studied whether intralesional injection of local anesthetic could reproduce similar histologic findings.A 45‐year‐old Japanese female visited us with a solitary, brownish papule on the chest. Histology revealed numerous nests composed of round to oval‐shaped nevus cells throughout the entire dermis. In the mid‐dermis, nevus cells were lined up in a layer anastomosing and forming a vascular space‐like structure. These nevus cells were uniformly stained with vimentin and S100 protein but not with factor VIII‐related antigen. They were also positively immunoreactive with anti‐type IV collagen and anti‐fibronectin. There were no significant differences in staining intensity in the nevus cells between the solid portion and the vascular space‐like structure.In the experimental study, eight melanocytic nevi were removed under local anesthesia. The local anesthetic solution was then injected into the excised nevus. Intralesional injection of a considerable volume of local anesthetic was capable of causing slits or clefts of the nests and dermal edema; however, it failed to reproduce a vascular space‐like structure similar to that in the present case. These findings suggest that a vascular space‐like structure in melanocytic nevus is not caused by the injection alone. Some other factor(s) may play a major role in the development of such structures in melanocytic nevus.
A Large Number of Tandem Repeats in the Polymorphic Epithelial Mucin Gene Is Associated with Severe Acne
Authors: Ando Iwao , Kukita Atsushi , Soma Genichiro , Hino Haruko 
Published: April 2015

AbstractPolymorphic epithelial mucin (PEM) or MUC1 is a glycoprotein secreted from various epithelial gland tissues. In skin, PEM is detected in sweat glands and sebaceous glands by the DF3 monoclonal antibody. The gene of PEM includes an allele exhibiting length polymorphism due to a variable number of tandem repeats (VNTR); this is expressed co‐dominantly, which may influence the microenvironment of the skin. The allelic size variation of the PEM gene was investigated in Japanese acne patients, atopic dermatitis patients, and healthy controls. The frequency of longer length alleles was significantly higher in severe acne patients.
HLA Antigens and Linkage Disequilibrium Patterns in Turkish Behçet's Patients
Authors: Alpsoy Erkan , Yilmaz Ertan , Coşkun Mesut , Savaş Ayşe , Yeğin Olcay 
Published: April 2015

AbstractBehçet's disease (BD) is a multisystem disorder featuring mucocutaneous, ocular, articular, vascular, intestinal, pulmonary, and neurologic involvement. Although the pathogenesis of the disease is still unknown, most studies have proposed that immunologic factors may play a major role in its development in genetically predisposed individuals.Seventy‐one Turkish patients with BD, diagnosed according to the International Study Group for Behçet's Disease criteria, were studied and compared with 600 healthy controls to determine not only frequencies of HLA‐A, B, and DR antigens but also whether BD shows any distinct linkage disequilibrium (LD) patterns. In addition, three‐point linkage disequilibrium and relative risk (RR) values were determined.Of the HLA‐A, B, and DR antigens examined, only B5 (51) was significantly increased in the patient group (X2=55.4; p<0.05; RR=6.44). DR7 was significantly decreased in the patient group (X2=6.9; p>0.05; RR=0.31). HLA haplotype B5‐DR5 was found to be in negative LD in the control group, but Behçet's patients showed a strong positive LD between these two antigens. HLA haplotypes A2‐B12, B5‐DR2, and B12‐DR4 showed negative LD in the patients; A1‐B5 and B5‐DR5 had positive LD in the patients. HLA haplotype A2‐B5‐DR5 was found to be more frequent than expected in both patients and control gorups. A2‐B12‐DR4 showed a negative LD in the patients.The strong LD patterns between HLA‐B and DR antigens in BD suggest that the susceptibility gene to BD could reside between the these two antigens.
Recurrent Annular Erythema in a Case of Seronegative Sjögren's Syndrome
Authors: Yamagami Yoshie , Ichikawa Kaoru , Mukuno Akira , Eto Hikaru 
Published: April 2015

AbstractWe describe a case of Sjögren's syndrome who repeatedly developed annular erythema on her extremities. Her anti‐nuclear antibody, anti‐SSA/Ro antibody, and anti‐SSB/La antibody were all negative. Characteristics of the annular erythema included a tendency to appear on the extremities especially in summer, spontaneous regression after 1–2 weeks, and residual slight pigmentation. The histological findings revealed dermal perivascular lymphocytic infiltration admixed with some neutrophils. Slight exsudative changes were found in the upper dermis. There were no epidermal changes. This case suggests the existence of annular erythema which may not be related to the anti‐SSA/Ro or anti‐SSB/La antibody. Unknown factors other than those antibodies may be involved in the pathogenesis of the annular erythema.
A Case of Cutaneous Ki‐1 Positive Anaplastic Large Cell Lymphoma in a Hemodialysed Patient
Authors: Kamada Noriaki , Kuwahara Takeichirou , Hatamochi Atsushi , Shinkai Hiroshi 
Published: April 2015

AbstractA 66‐year‐old woman who suffered from chronic glomerulonephritis had been undergoing hemodialysis for about 10 years. A reddish papule on her waist developed gradually into a nodule (1.9 × 1.4 cm). Histopathological findings showed that the tumor cells had oval to reniform nuclei; multinucleated neoplastic cells and erythrophagocytosis were also present. Immunohistochemical analyses revealed that the membranes of the tumor cells stained for Ber‐H2 (Ki‐1) and epithelial membrane antigen (EMA), Vimentin was partially positive, but keratin, S‐100, chromogranin, leukocyte common antigen (LCA), UCHL‐1, MT‐1, L‐26, MB‐1 and C3D‐1 were all negative. Anti‐human T‐cell leukemia virus‐1 (HTLV‐1) was also negative. No gene rearrangement of the T‐cell receptor β‐, γ‐ and δ‐chain could be detected. From these results, we diagnosed cutaneous Ki‐1 anaplastic large cell lymphoma (ALCL), but the origin could not be determined. The relationship between lymphoma and chronic renal failure and/or hemodialysis was far from clear.
Pyodermia Chronica Glutealis Complicated by Acromegalic Gigantism
Authors: Nishijima Setsuko , Kasahara Mika , Suzuki Kenji , Kondoh Masako , Tsubura Airo 
Published: April 2015

AbstractWe report a case of pyodermia chronica glutealis complicated by acromegalic gigantism associated with hyperprolactinemia. The serum prolactin, growth hormone, adrenocorticotropic hormone, and 11‐deoxycortisol levels were elevated, but the estradiol and dehydroepiandrosterone‐sulphate levels were within normal limits. However, the testosterone level was very low. Histopathologically, we found sinus tracts and scarring in a specimen from the buttocks. We could not immunohistochemically detect clear androgen, growth hormone, or prolactin receptors at any site. The patient was a man with a height of 197 cm and weight of 140 kg, he had clinical features of active acromegaly such as excessive sweating and increased thickness of soft tissue. He was also diagnosed with diabetes mellitus. Under such conditions, bacteria could easily grow and lesions might have been aggravated by the heavy pressure from his weight, a possible causes of his pyodermia chronica glutealis.
Two Cases of Unilateral Axillary Paget's Disease
Authors: Ohno Haruhiko , Hatoko Mitsuo , Kuwahara Masamitsu , Ohnuma Yoshiyuki , Iida Takashi , Muramatsu Tsutomu , Shirai Toshihiko 
Published: April 2015

AbstractWe herein report two cases of unilateral axillary Paget's disease. Extramammary Paget's disease commonly occurs in the anogenital area. Unilateral axillary occurrence is relatively rare. One defect was reconstructed with a pedicled scapular flap, and the other was reconstructed with split‐skin graft after excision of the tumor. No recurrence was seen in either patient three years postoperatively. However, although the patient who had been reconstructed with a pedicled flap recovered uneventfully, the other patient, who had been reconstructed with a split‐skin graft, suffered from axillary contracture due to the shrinkage of the grafted skin after surgery. A skin graft requires fixation for a long period to prevent shrinkage, which causes axillary contracture. Therefore, from the viewpoint of quality of life, reconstruction using flaps is recommended for axillary lesions.
Generalized Erythematous Skin Eruptions Due to Trimethoprim Itself and Co‐Trimoxazole
Authors: Hattori Naoko , Hino Haruko 
Published: April 2015

AbstractA 20‐year‐old Japanese woman (Case 1) and a 70‐year‐old Japanese man (Case 2) consulted us with slight fever and disseminated erythematous papules. Examinations revealed that the first case was a skin eruption due to trimethoprim itself and the second was due to both trimethoprim and sulphamethoxazole. To our knowledge, our Case 1 is the first reported case with an erythematous papular type skin eruption caused by trimethoprim itself, and our Case 2 is the first case of a skin eruption in reaction to both trimethoprim and sulphamethoxazole.
A Case of Seborrheic Keratosis Distributed along Skin Cleavage Lines
Authors: Li Xiaojie , Zhu Wenyuan 
Published: April 2015

AbstractA 65‐year‐old woman with seborrheic keratosis following skin cleavage lines is reported. The mostly brownish‐yellow lesions were located on the back. The round, oval, spindle, comet, and slightly raised papules varied from 1 mm to 2 cm in diameter. The distribution of lesions was unusual; they tended to follow skin cleavage lines on her lower back and waist. The arrangement of lesions was streamlined. The skin biopsy specimen revealed hyperkeratosis, acanthosis, and papillomatosis. The acanthosis was caused by proliferation of squamous and basaloid cells.
Superficial Spreading Melanoma Arising in a Longstanding Melanocytic Nevus on the Sole
Authors: Cho Kwang Hyun , Han Kwang Ho , Minn Kyung Won 
Published: April 2015

AbstractIn Asians, the plantar surface is the commonest site for cutaneous melanoma, and most melanomas arising in this region are the acral lentiginous type. Herein we describe a rare case of superficial spreading melanoma arising in a longstanding melanocytic nevus on the sole of a Korean.
Local Cytokine Expression in Steroid‐Modified Tinea Faciei
Authors: Ohta Yukinori , Saitoh Norimitsu , Tanuma Hiroyuki , Fujimura Takao , Katsuoka Kensei 
Published: April 2015

AbstractIn tinea faciei, a dermatophyte infection of the face, early stage lesions show erythema with crust and/or vesicles, a condition often misdiagnosed as dermatitis. Steroid application retards the healing in some cases and may induce penetration of the dermatophyte hyphae into hair and hair follicles. In the present study, we examined local immunity mediated by cytokines derived from lesional T lymphocytes in late stage of this disease. Interferon‐gamma (IFN‐γ) and macrophage migration inhibitory factor (MIF) were highly expressed, but neither interleukin‐4 (IL‐4) nor interleukin‐5 (IL‐5) could be detected by RT‐PCR using cryosections. These data suggested that IFN‐γ and MIF may be important in the delayed‐type hypersensitivity (DTH) response against the fungus in the hair follicle in late stages.
A Pediatric Case of Atypical Mycobacterium avium Infection of the Skin
Authors: Noguchi Hiromitsu , Hiruma Masataro , Kawada Akira , Fujimoto Norihiro , Fujioka Akira , Ishibashi Akira 
Published: April 2015

AbstractWe report a case of cutaneous atypical mycobacteriosis in a 12‐year‐old healthy girl due to Mycobacterium avium. The cutaneous symptoms were three well‐defined subcutaneous nodules on both buttocks and on the posterior surface of the left thigh. One had a fistulous opening on the skin surface. Histopathological examination revealed epithelioid cell granulomas surrounded by dense lymphocytic infiltration and acid‐fast bacteria were seen with modified periodic acid‐carbol fuchsin staining. Using Ogawa's medium at 37°C, acid‐fast bacteria were isolated from the biopsied specimen and identified by the DNA‐DNA hybridization method as Mycobacterium avium. In drug susceptibility test, these were resistant to all antituberculous drugs. Oral administration of minocycline 100 mg/day for two months had little effect on the two remaining lesions, which were therefore excised. Based upon reported cases of Mycobacterium avium complex, we considered that our pediatric patient with multiple intradermal or subcutaneous nodules on the buttocks and the thigh exhibited the characteristic symptoms of M. avium infection.
A Case of Subcutaneous Cysticercosis
Authors: Matsushima Hironori , Hatamochi Atsushi , Shinkai Hiroshi , Shimizu Motota , Hatsushika Ryo 
Published: April 2015

AbstractWe report the fourth case of subcutaneous cysticercosis infected in Japan since 1975. The patient noticed a subcutaneous nodule on his left shoulder without symptoms for three years. No remarkable changes were found in laboratory findings and physical examination after surgical excision of the subcutaneous nodule. The adult worm of Taenia solium could not be found in the intestine. Histological findings revealed a cystic structure with a fibrous capsule and a protoscolex with suckers, hooks, and calcareous corpuscula. It was identified as a Cysticercus cellulosae hominis based on morphological characteristics. The patient has been living in the Kanto area of Japan and has never been outside Japan since he was born.
A Case of Dystrophic Epidermolysis Bullosa: Surgical Treatment for Hand Contracture Using Abdominal Skin Flap
Authors: Muramatsu Tsutomu , Hatoko Mitsuo , Shirai Toshihiko , Vanittanakom Pramote 
Published: April 2015

AbstractThe patient was a 15‐year‐old male. Since birth, he has suffered from recurrent blistering, especially on the extremities. Histology and electron microscopic findings of the cutaneous lesions were compatible with those of dystrophic epidermolysis bullosa. Contracture and mobility limitation of the hands had gradually deteriorated. Prior to the admission to our clinic, both hands' contracture had been surgically treated 4 times in another hospital; however, after treatment with skin grafting, hand contracture recurred each time within one year. This time, surgical treatment was carried out for his left hand contracture using an abdominal skin flap under local anesthesia. In comparison with the free skin graft, the abdominal skin flap improved hand contracture for a longer time. Abdominal skin flap is recommended as a method for the treatment of hand contracture of patients with dystrophic epidermolysis bullosa.
Primary Sjögren's Syndrome Followed by Chronic Myelogenous Leukemia: A Case Report with a Ten Year History
Authors: Minowa Rui , Miyagawa Sachiko , Fukumoto Takaya , Majima Toshimasa , Shimoyama Taketo , Fujimura Yoshihiro , Shirai Toshihiko 
Published: April 2015

AbstractWe describe a female patient with primary Sjögren's syndrome who subsequently developed chronic myelogenous leukemia. The patient received a bone marrow transplant (BMT) from a genotypically HLA‐identical brother after pre‐transplant preparation with busulfan and cyclophosphamide. Eighteen weeks later, cutaneous and mucosal chronic graft‐versus‐host disease developed, followed by death 11 months after transplantation. Anti‐Ro/SS‐A antibodies disappeared within 6 months post‐BMT, but antinuclear antibodies remained positive through the post‐transplant course.
Bullous Pemphigoid Associated with Shy‐Drager Syndrome
Authors: Okazaki Aiko , Iida Takashi , Muramatsu Tsutomu , Shirai Toshihiko , Murata Kenya , Takayanagi Tetsuya 
Published: April 2015

AbstractWe report a patient with Shy‐Drager syndrome who developed multiple tense blisters mainly on the extremities. Circulating anti‐basement membrane zone autoantibodies were detected by the indirect immunofluorescence method. Immunoblot analysis using normal human epidermal extracts demonstrated that this patient's serum reacted only with 230 kD bullous pemphigoid antigen (BPAG1). Concerning the pathoetiology of the association of bullous pemphigoid and Shy‐Drager syndrome, we discuss a sequence similarity between BPAG1 and dystonin, a candidate gene for dystonia musculorum.
Successful Treatment of Transient Acantholytic Dermatosis with Systemic Steroids
Authors: Erõs Nóra , Kovács Anikó , Károlyi Zsuzsanna 
Published: April 2015

AbstractA sixty‐year‐old man, developed 2–5 mm sized, hyperemic, itchy papules, vesicles, erosions and crusts on hyperemic base on his chest, abdomen, back, gluteal region, and proximal sites of his upper and lower extremities. The direct and indirect immunoflurescence tests were negative. Histology revealed extensive acantholysis in the epidermis in the following forms: pemphigus vulgaris‐like suprabasal acantholysis, Darier‐like acantholytic dyskeratosis with corps ronds, Hailey‐Hailey‐like suprabasal clefts, and pemphigus foliaceus‐like superficial acantholysis with spongiosis. Using systemic steroids, topical drying, and reepithelising therapy, the patient was cured. He was symptom‐free the first, fourth, and thirteenth months after finishing steroid therapy.We review the literature and the new subdivision of the disease according to the histological and clinical features.
Immunobead and Density Gradient Purification of Paget Cells: In vitro Studies of Proliferation
Authors: Mori Osamu , Miyasato Minoru , Karashima Tadashi , Hashimoto Takashi 
Published: April 2015

AbstractPrevious studies using primary monolayer cultures of epithelial cells from the involved epidermis of patients with mammary and extramammary Paget's disease investigated whether Paget cells proliferate as other malignant cells do. Although epithelial monolayers from the involved skin were maintained for approximately 45 days, no permanent cell lines were established. The proportion of carcinoembryonic antigen (CEA)‐positive cells did not increase in the long‐term cultures.Herein, we report studies of whether there is a real reduction of Paget cell numbers or if this is merely a decrease in the expression of CEA by the cells. Furthermore, we investigated whether Paget cells survive longer when cultured free from any potential inhibitory keratinocytes or other epidermal cells.Skin samples were obtained from one patient with mammary Paget's disease and three with extramammary Paget's disease; epidermal cells were cultured in vitro. An enrichment of Paget cells was carried out from the cultured epidermal cells by combining an anti‐epithelial membrane antigen monoclonal antibody, binding to immunobeads, and density gradient centrifugation in Nycodenz. The separated cells were re‐cultured in Keratinocyte‐SFM serum‐free media.The proportion of CEA‐positive cells did not increase in the cultures, and the purified cells did not show any increase in survival times compared to the non‐purified cultured cells. These results suggest that the decrease of CEA‐positive cells noted during culture results from a decline in expression of CEA in the Paget cells. Paget cells in the involved epidermis do not proliferate significantly and thus differ from many other malignant cells.
A Case of Infantile Digital Fibromatosis with Spontaneous Regression
Authors: Kawaguchi Masakazu , Mitsuhashi Yoshihiko , Hozumi Yutaka , Kondo Shigeo 
Published: April 2015

AbstractWe reported a fourteen‐month‐old boy with infantile digital fibromatosis. At the age of seven months, a nodule appeared on the back of the left third toe, and developed into a slight red tumor divided into five hemispherical nodules. Histopathologically, spindle‐shaped tumor cells with an eosinophilic inclusion body in the cytoplasm were seen in the dermis. Electron microscopy showed a dense body in the cytoplasm of the tumor cells. One year and two months after the first visit, the tumor regressed without any aggressive treatment. Japanese cases of infantile digital fibromatosis were reviewed. The literature review and our case suggest that the tumor should be observed without any aggressive treatment unless it causes mobile dysfunction of the affected finger or toe.
Disseminated Cutaneous Rhinosporidiosis
Authors: Thappa Devinder Mohan , Venkatesan Sivaraman , Sirka Chandra Sekhar , Jaisankar Telanseri Jayakar , Gopalkrishnan  , Ratnakar Chaganti 
Published: April 2015

AbstractTwo cases of longstanding rhinosporidiosis developed widespread asymptomatic nodular skin lesions. Cutaneous examination showed multiple, discrete, sessile and pedunculated, smooth and warty, friable nodular lesions of variable sizes and shapes. Histopathology of representative skin lesions showed hyperplastic epidermis with sporangia containing spores in the upper dermis diagnostic of rhinosporidiosis. Epidemiological data about rhinosporidiosis at Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India, is presented. Possible modes of dissemination to the skin and differential diagnosis are discussed in relation to this rare manifestation of rhinosporidiosis.
Dermatomyositis and Nasopharyngeal Carcinoma
Authors: Abraham Zeev , Rosner Itzhak , Rozenbaum Michael , Goldenberg Katalin , Weller Boaz 
Published: April 2015

AbstractA nasopharyngeal carcinoma was diagnosed in a 37‐year‐old man with a two year history of dermatomyositis. The physical and laboratory examinations excluded further medical problems. To our knowledge, this is the first case of dermatomyositis associated with nasopharyngeal carcinoma in a white Israeli Jewish patient.