bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Inducible Costimulator Augments Tc17 Cell Responses to Self and Tumor Tissue
Authors: Nelson Michelle H. , Kundimi Sreenath , Bowers Jacob S. , Rogers Carolyn E. , Huff Logan W. , Schwartz Kristina M. , Thyagarajan Krishnamurthy , Little Elizabeth C. , Mehrotra Shikhar , Cole David J. , Rubinstein Mark P. , Paulos Chrystal M. 
Published: January 2015

Abstract
The inducible costimulator (ICOS) plays a key role in the development of Th17 cells, but its role in the development and antitumor activity of IL-17–producing CD8+ T cells (Tc17) remains unknown. We found that ICOS costimulation was important for the functional maintenance, but not differentiation, of Tc17 cells in vitro. Blocking the ICOS pathway using an antagonist mAb or by using recipient mice genetically deficient in the ICOS ligand reduced the antitumor activity of adoptively transferred Tc17 cells. Conversely, activating Tc17 cells with an ICOS agonist in vitro enhanced their capacity to eradicate melanoma and induce autoimmune vitiligo when infused into mice. However, ICOS stimulation did not augment the antitumor activity of IL-2 expanded T cells. Additional investigation revealed that ICOS stimulation not only increased IL-2Rα, CXCR3, and IL-23R expression on Tc17 cells, but also dampened their expression of suppressive molecule CD39. Although Tc17 cells activated with an ICOS agonist cosecreted heightened IL-17A, IL-9, and IFN-γ, their therapeutic effectiveness was critically dependent on IFN-γ production. Depletion of IL-17A and IL-9 had little impact on antitumor Tc17 cells activated with an ICOS agonist. Collectively, our work reveals that the ICOS pathway potentiates the antitumor activity of adoptively transferred Tc17 cells. This work has major implications for the design of vaccine, Ab and cell-based therapies for autoimmunity, infectious disease, and cancer.
Alternatively Spliced Myeloid Differentiation Protein-2 Inhibits TLR4-Mediated Lung Inflammation
Authors: Tumurkhuu Gantsetseg , Dagvadorj Jargalsaikhan , Jones Heather D. , Chen Shuang , Shimada Kenichi , Crother Timothy R. , Arditi Moshe 
Published: January 2015

Abstract
We previously identified a novel alternatively spliced isoform of human myeloid differentiation protein-2 (MD-2s) that competitively inhibits binding of MD-2 to TLR4 in vitro. In this study, we investigated the protective role of MD-2s in LPS-induced acute lung injury by delivering intratracheally an adenovirus construct that expressed MD-2s (Ad-MD-2s). After adenovirus-mediated gene transfer, MD-2s was strongly expressed in lung epithelial cells and readily detected in bronchoalveolar lavage fluid. Compared to adenovirus serotype 5 containing an empty vector lacking a transgene control mice, Ad-MD-2s delivery resulted in significantly less LPS-induced inflammation in the lungs, including less protein leakage, cell recruitment, and expression of proinflammatory cytokines and chemokines, such as IL-6, keratinocyte chemoattractant, and MIP-2. Bronchoalveolar lavage fluid from Ad-MD-2s mice transferred into lungs of naive mice before intratracheal LPS challenge diminished proinflammatory cytokine levels. As house dust mite (HDM) sensitization is dependent on TLR4 and HDM Der p 2, a structural homolog of MD-2, we also investigated the effect of MD-2s on HDM–induced allergic airway inflammation. Ad-MD-2s given before HDM sensitization significantly inhibited subsequent allergic airway inflammation after HDM challenge, including reductions in eosinophils, goblet cell hyperplasia, and IL-5 levels. Our study indicates that the alternatively spliced short isoform of human MD-2 could be a potential therapeutic candidate to treat human diseases induced or exacerbated by TLR4 signaling, such as Gram-negative bacterial endotoxin-induced lung injury and HDM-triggered allergic lung inflammation.
Jelinek, Yeshayahu A.: "The Carpathian Diaspora: The Jews of Subcarpathian Rus' and Mukachevo"
Authors: Rosen Ilana 
Published: January 2015

Yeshayahu A. Jelinek, The Carpathian Diaspora: The Jews of Subcarpathian Rus' and Mukachevo. New York: East European Monographs, No. DCXXI. 480 pp. Reviewed by Ilana Rosen, Ben Gurion University.
Glant, Tibor. 2013. "Amerika, a csodák és csalódások földje." (America, the Land of Wonders and Disappointments.)
Authors: Glanz Susan 
Published: January 2015

Glant, Tibor. 2013. Amerika, a csodák és csalódások földje. Az Amerikai Egyesült Államok képe a hosszú XIX. század magyar utazási irodalmában (America, the Land of Wonders and Disappointments - the Picture of the United States of America in the Hungarian Travel Literature of the Long Nineteenth Century). Debrecen: University of Debrecen Press. 259 pp. Reviewed by Susan Glanz, St. John's University
Concise Review: Tailoring Bioengineered Scaffolds for Stem Cell Applications in Tissue Engineering and Regenerative Medicine
Authors: Cosson Steffen , Otte Ellen A. , Hezaveh Hadi , Cooper-White Justin J. 
Published: January 2015

Abstract

The potential for the clinical application of stem cells in tissue regeneration is clearly significant. However, this potential has remained largely unrealized owing to the persistent challenges in reproducibly, with tight quality criteria, and expanding and controlling the fate of stem cells in vitro and in vivo. Tissue engineering approaches that rely on reformatting traditional Food and Drug Administration-approved biomedical polymers from fixation devices to porous scaffolds have been shown to lack the complexity required for in vitro stem cell culture models or translation to in vivo applications with high efficacy. This realization has spurred the development of advanced mimetic biomaterials and scaffolds to increasingly enhance our ability to control the cellular microenvironment and, consequently, stem cell fate. New insights into the biology of stem cells are expected to eventuate from these advances in material science, in particular, from synthetic hydrogels that display physicochemical properties reminiscent of the natural cell microenvironment and that can be engineered to display or encode essential biological cues. Merging these advanced biomaterials with high-throughput methods to systematically, and in an unbiased manner, probe the role of scaffold biophysical and biochemical elements on stem cell fate will permit the identification of novel key stem cell behavioral effectors, allow improved in vitro replication of requisite in vivo niche functions, and, ultimately, have a profound impact on our understanding of stem cell biology and unlock their clinical potential in tissue engineering and regenerative medicine.
Manufacturing Road Map for Tissue Engineering and Regenerative Medicine Technologies
Authors: Hunsberger Joshua , Harrysson Ola , Shirwaiker Rohan , Starly Binil , Wysk Richard , Cohen Paul , Allickson Julie , Yoo James , Atala Anthony 
Published: January 2015

Abstract

Summary
The Regenerative Medicine Foundation Annual Conference held on May 6 and 7, 2014, had a vision of assisting with translating tissue engineering and regenerative medicine (TERM)-based technologies closer to the clinic. This vision was achieved by assembling leaders in the field to cover critical areas. Some of these critical areas included regulatory pathways for regenerative medicine therapies, strategic partnerships, coordination of resources, developing standards for the field, government support, priorities for industry, biobanking, and new technologies. The final day of this conference featured focused sessions on manufacturing, during which expert speakers were invited from industry, government, and academia. The speakers identified and accessed roadblocks plaguing the field where improvements in advanced manufacturing offered many solutions. The manufacturing sessions included (a) product development toward commercialization in regenerative medicine, (b) process challenges to scale up manufacturing in regenerative medicine, and (c) infrastructure needs for manufacturing in regenerative medicine. Subsequent to this, industry was invited to participate in a survey to further elucidate the challenges to translation and scale-up. This perspective article will cover the lessons learned from these manufacturing sessions and early results from the survey. We also outline a road map for developing the manufacturing infrastructure, resources, standards, capabilities, education, training, and workforce development to realize the promise of TERM.
NEW DEVELOPMENTS IN BEACH CLEANUP TECHNIQUES
Authors: Pasquet Richard , Denis Jacques 
Published: January 2015

ABSTRACT
French coasts have been polluted several times by oil, and intensive cleanup was necessary to restore the hundreds of kilometers of contaminated shore. The spills provided a wide field of experiences for beach cleanup techniques. Only human labor or usual public works and agricultural equipment were available, and all of them were limited either in the quantity or selectivity of wastes collected.
The Centre de Documentation de Recherche et d'Expérimentations sur les Pollutions accidentelles des eaux (CEDRE) started working in 1979 to develop equipment with better performance. First, it investigated existing equipment, and particularly agricultural technology, for its versatility and ability to work on smooth soils. Then it compared the performances of several beach cleaners used to pick up litter and seaweed during the summer. CEDRE finally decided to improve one of these beach cleaners by adding a “kit” for use on agglomerated oil. This kit now is available and has been tested successfully in the field.
But no existing equipment was found to be really effective on fresh oil stranded on shore. Therefore, three years of hard work were devoted to the development of another new piece of equipment which has been tested in the field and now is available. It is a specific type of drum, lined with a collecting material which can recover a layer of oil on sand, with the oil reaching 50 percent in volume. The wastes are transferred immediately to an agricultural vehicle or a dump truck.
Several units of each of these two types of equipment will be bought by French authorities.
Polarization observations of 4fce auroral roar emissions
Authors: Sato Yuka , Kadokura Akira , Ogawa Yasunobu , Kumamoto Atsushi , Katoh Yuto 
Published: January 2015

AbstractWe report on the first polarization measurement of auroral roar emissions near 4 times the ionospheric electron cyclotron frequency (4fce). A ground‐based passive receiver that uses orthogonal loop antennas, installed in Iceland, revealed the sense of polarization of 11 events of 4fce roar emissions. In 9 of 11 cases, 4fce roar was left‐handed elliptically polarized, namely, O‐mode waves. The O‐mode 4fce roar was observed under both sunlit and dark ionospheric conditions during geomagnetic storms. For O‐mode 4fce roar generation, satisfaction of the matching condition where upper hybrid frequency (fUH) equals 4fce requires a high‐density, F region ionosphere, even during darkness, which might be attributed to auroral precipitation or tongue of ionization. In two cases, right‐handed elliptically polarized 4fce roar was observed during darkness hours and the main phase of a geomagnetic storm. This polarization indicates that nonlinear coupling of two upper hybrid waves may also work to generate X‐mode 4fce roar.
Lower hybrid drift instability at a dipolarization front
Authors: Divin A. , Khotyaintsev Yu. V. , Vaivads A. , André M. 
Published: January 2015

AbstractWe present observations of a reconnection jet front detected by the Cluster satellites in the magnetotail of Earth, which are commonly referred to as dipolarization fronts. We investigate in detail electric field structures observed at the front which have frequency in the lower hybrid range and amplitudes reaching 40 mV/m. We determine the frequency and phase velocity of these structures in the reference frame of the front and identify them as a manifestation of the lower hybrid drift instability (LHDI) excited at the sharp density gradient at the front. The LHDI is observed in the nonlinear stage of its evolution as the electrostatic potential of the structures is comparable to ∼ 10% of the electron temperature. The front appears to be a coherent structure on ion and MHD scales, suggesting existence of a dynamic equilibrium between excitation of the LHDI and recovery of the steep density gradient at the front.
Effect of water phase transition on dynamic ruptures with thermal pressurization: Numerical simulations with changes in physical properties of water
Authors: Urata Yumi , Kuge Keiko , Kase Yuko 
Published: January 2015

AbstractPhase transitions of pore water have never been considered in dynamic rupture simulations with thermal pressurization (TP), although they may control TP. From numerical simulations of dynamic rupture propagation including TP, in the absence of any water phase transition process, we predict that frictional heating and TP are likely to change liquid pore water into supercritical water for a strike‐slip fault under depth‐dependent stress. This phase transition causes changes of a few orders of magnitude in viscosity, compressibility, and thermal expansion among physical properties of water, thus affecting the diffusion of pore pressure. Accordingly, we perform numerical simulations of dynamic ruptures with TP, considering physical properties that vary with the pressure and temperature of pore water on a fault. To observe the effects of the phase transition, we assume uniform initial stress and no fault‐normal variations in fluid density and viscosity. The results suggest that the varying physical properties decrease the total slip in cases with high stress at depth and small shear zone thickness. When fault‐normal variations in fluid density and viscosity are included in the diffusion equation, they activate TP much earlier than the phase transition. As a consequence, the total slip becomes greater than that in the case with constant physical properties, eradicating the phase transition effect. Varying physical properties do not affect the rupture velocity, irrespective of the fault‐normal variations. Thus, the phase transition of pore water has little effect on dynamic ruptures. Fault‐normal variations in fluid density and viscosity may play a more significant role.
Developmental stage‐dependent influence of environmental factors on growth of rural Sundanese children in West Java, Indonesia
Authors: Sekiyama Makiko , Roosita Katrin , Ohtsuka Ryutaro 
Published: January 2015

ABSTRACTThis study investigated the growth trajectories and the relative relevance levels of nutrition, disease, and hormonal status at various developmental stages among children in adverse environments to provide population‐based empirical evidence for the life history theory. Three years of longitudinal anthropometric data in 1‐year intervals were obtained from 418 boys and girls aged 0 to 12 years at recruitment. Following the final measurement, the main survey, which included blood and feces sampling, 3‐h interval food consumption recall surveys for energy and nutrient intakes and anthropometry, was performed. Blood and feces were used for detecting, respectively, anemia and hormonal (IGF‐I and IGFBP‐3) levels as well as intestinal helminthiasis (Ascaris, Trichuris, and hookworm). The major findings of this study are summarized as follows: 1) the growth velocity of the subject children lagged behind international standards during childhood and juvenility but caught up during early adolescence; 2) diseases, both intestinal helminths and anemia, had significant effects on growth in childhood but not at older ages; and 3) hormonal status significantly affected growth in the children, with its highest significance in early adolescence. A larger growth than international standards in early adolescence likely follows programmed hormonal mechanisms after the onset of puberty. The onset of puberty might be associated with adequate amounts of nutrient intake and be mediated by hormonal function, because the IGF‐IZ score was significantly correlated with energy and protein intakes at the transitional period from juvenility to adolescence, when puberty occurs. Am J Phys Anthropol 157:94–106, 2015. © 2015 Wiley Periodicals, Inc.
Food Security in India: The Imperative and Its Challenges
Authors: Narayanan Sudha 
Published: January 2015

AbstractThis article addresses the imperative of food security in India in the context of persistent prevalence of malnutrition despite several years of rapid growth. In particular, the article posits that the recent promulgation of the National Food Security Act in September 2014 to meet this challenge also offers an opportunity to reconfigure its food distribution system and agricultural trade policy. These two issues pose the greatest and most immediate challenges for India. The more enduring challenge for India would be to sustain food production to ensure not only adequate quantities, but also to support dietary quality and diversity.
Managing the quality of e‐learning resources in repositories
Authors: Pons Daniel , Hilera Jose Ramon , Fernandez Luis , Pages Carmen 
Published: January 2015

ABSTRACTVirtual learning in engineering education uses e‐learning resources in many different ways. These resources are normally stored in learning object repositories (LOR) where they are catalogued with metadata facilitating retrieval by end users. As ranking e‐learning resources according to quality criteria is considered helpful for end users, quality measures play a prominent role. This article presents a study for estimating the quality of learning objects (LO) by using the available data in MERLOT, a large LOR. The main result of this study is the identification, definition, and evaluation of quality metrics applicable to engineering e‐learning resources which can be adapted to other types of repositories for facilitating the search of e‐resources in general. © 2015 Wiley Periodicals, Inc. Comput Appl Eng Educ 23:477–488, 2015; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21619
Hospital Volume and Cardiac Complications of Endomyocardial Biopsy: A Retrospective Cohort Study of 9508 Adult Patients Using a Nationwide Inpatient Database in Japan
Authors: Isogai Toshiaki , Yasunaga Hideo , Matsui Hiroki , Ueda Tetsuro , Tanaka Hiroyuki , Horiguchi Hiromasa , Fushimi Kiyohide 
Published: January 2015

ABSTRACTBackgroundRecent research on complications with endomyocardial biopsy (EMB) has been based on single‐center or 2‐center studies in high‐volume cardiovascular centers. No study has examined the association between hospital volume and the complication rate after EMB.HypothesisHospital volume is inversely associated with cardiac complication rate after EMB.MethodsUsing the Diagnosis Procedure Combination database in Japan, we identified inpatients aged ≥20 years who underwent EMB under fluoroscopic guidance. We assessed cardiac complications requiring the following urgent procedures on the day of EMB or the day after: pericardiocentesis, surgical repair, and temporary pacing.ResultsAmong 9508 eligible patients in 491 hospitals (male, 68%; mean age, 57.0 years), dilated cardiomyopathy was the most frequently diagnosed condition (35.4%). Twenty‐four patients (0.25%) required pericardiocentesis on the day of EMB. Three patients (0.03%) underwent surgical repair on the day of EMB or the day after. Sixty‐three patients (0.70%) required temporary pacing on the day of EMB. Higher hospital volume was associated with lower rates of pericardiocentesis (low volume, 0.4%; medium volume, 0.2%; high volume, 0.1%; P for the trend test, 0.019) and temporary pacing (low volume, 1.0%; medium volume, 0.7%; high volume, 0.2%; P for the trend test, < 0.001). In a multivariable logistic regression analysis, high hospital volume was significantly associated with a lower rate of the composite outcome of the procedures (reference, low volume; adjusted odds ratio, 0.22; 95% confidence interval, 0.08–0.62, P = 0.004).ConclusionsSerious cardiac complications of EMB were rare, but higher hospital volume was associated with lower complication rate.
Current unmet needs of cancer survivors: Analysis of open‐ended responses to the American Cancer Society Study of Cancer Survivors II
Authors: Burg Mary Ann , Adorno Gail , Lopez Ellen D. S. , Loerzel Victoria , Stein Kevin , Wallace Cara , Sharma Dinghy Kristine B. 
Published: January 2015

BACKGROUNDCancer survivors may continue to experience psychosocial and physical needs related to their cancer experience for many years after treatment. The specification of these needs across cancer types and by survivor characteristics may lead to better prevention approaches and clinical responses. Mixed methods were used to examine responses to an open‐ended question about current unmet needs from a survey of 2‐, 5‐, and 10‐year cancer survivors.METHODSQualitative techniques were used to code themes of unmet needs from open‐ended responses. These themes were then examined with quantitative techniques to describe the frequency of unmet needs across disease subgroups and demographic subgroups of survivors.RESULTSThere were 1514 responses to the open‐ended question on unmet needs. Respondents ranged in age from 24 to 97 years and included proportionately more women, and 18% were minorities (black and Hispanic). Sixteen themes of unmet needs were identified. The number and type of unmet needs were not associated with the time since cancer treatment. Breast cancer survivors identified more unmet needs than other survivors. Male survivors and especially prostate cancer survivors identified personal control problems as current needs. Older cancer survivors identified fewer unmet needs on average than younger survivors.CONCLUSIONSThis analysis of an open‐ended question on unmet needs extends our understanding of how cancer survivors perceive problems related to cancer. How cancer‐related needs change over time and differ by sex, race, and ethnicity and how problems with personal control become manifest are areas of inquiry requiring further research. Cancer 2015;121:623–630. © 2015 American Cancer Society.
Hydrostannylation–Cross‐Coupling Strategy for the Stereoselective Synthesis of Alkylidenemalonates and Related α,β‐Unsaturated Esters
Authors: Fujiwara Shinichi , Cadou Romain , Yamaoka Yousuke , Takasu Kiyosei , Yamada Ken‐ichi 
Published: January 2015

AbstractA method for the stereoselective synthesis of alkylidenemalonates and related α,β‐unsaturated esters by a hydrostannylation–cross‐coupling process has been developed. Pd‐catalyzed and radical hydrostannylation of propiolate derivatives stereoselectively provided α‐alkoxycarbonyl (E)‐ and (Z)‐vinylstannanes, respectively, which were then converted into alkylidenemalonates by the Stille coupling reaction. A one‐pot process was also realizable for the Pd‐catalyzed reactions.