bluuebunny/crossref_metadata_2025_split huggingface dataset:
A delayed diagnosis of hyperthyroidism in a patient with persistent vomiting in the presence of Chiari type 1 malformation
Authors: Rodriguez-Hurtado Diana , Camones-Huerta José , Núñez Mochizaki Claudia 
Published: August 2024

Abstract

Objectives
To present and discuss an uncommon clinical presentation of hyperthyroidism in a female patient with Chiari type 1 malformation. We explore how her medical history influenced the diagnostic process and ultimately contributed to the delayed diagnosis.

Case presentation
In this case study, we discuss an unusual presentation of hyperthyroidism in a 35-year-old female with Chiari type 1 malformation. Initially experiencing headaches, tremors, and dizziness, the patient consulted multiple specialists without a clear diagnosis. Later, she developed recurrent vomiting unrelated to food intake, significant weight loss (12 kg), and muscle weakness, leading to her hospitalization. After six months of clinical evaluation with several specialists (neurologists, neurosurgeons, and gastroenterologists), she was, finally, diagnosed with hyperthyroidism by an Internal Medicine physician in another private clinic. Treatment with thiamazole and propranolol led to the improvement of symptoms progressively. This case emphasizes the vital role of clinical reasoning, crucial problem-solving, and decision-making processes while addressing cognitive biases in medical specialization. Besides, it highlights the need for internist evaluation in outpatient care to ensure comprehensive assessment and prompt specialist referrals if needed.

Conclusions
This case accentuates the importance of internist evaluation for comprehensive care and timely specialist referrals. Recognizing unusual presentations, like thyrotoxic vomiting, and addressing cognitive biases, such as confirmation and anchor biases, are crucial for accurate and prompt diagnosis. This approach enhances diagnostic accuracy, minimizing unnecessary tests and costs, and alleviates patient suffering.
Effect of Zr content on the microstructure, mechanical properties, electrochemical behavior, and biocompatibility of Mg–3Zn–xZr alloy using powder metallurgy
Authors: Yahyazameh Marziyeh , Kavanlouei Majid , Shahbaz Mehrdad , Beygi-Khosrowshahi Younes 
Published: August 2024

Abstract
In this study, Mg–3Zn–xZr (x = 0, 0.5, 1, 2 and 3) alloy were produced using powder metallurgy incorporating high-energy ball milling. Scanning electron microscope (SEM), energy dispersive X-ray (EDX) analyzer and X-ray diffraction (XRD) have been used to investigate the microstructure, chemical composition and phase distribution of the samples. XRD results show that the Mg solid solution wholly formed, and the milled powders were single phase, and no secondary phase was observed. While the secondary phases were formed after sintering. Hardness of Mg–Zn–xZr sample increased from 58.8 Hv (for Zr = 0) to 87.81 Hv with addition of 3 wt.% Zr. The result shows that the corrosion potential of Mg–Zn–Zr alloy was more positive than Mg–3Zn. However, the Mg–3Zn–Zr alloy exhibited higher corrosion current than Mg–3Zn due to galvanic effect of Zr rich area. All of Mg–3Zn–Zr alloys showed better antibacterial and biocompatibility properties than Mg–3Zn alloy due to the presence of Zr as additive. According to the mechanical, corrosion, and biological evaluations in this study, it can be concluded that the Mg–3Zn–1Zr alloy can be used as a suitable biomaterial for the use of orthopedic implants.
Real-world evidence evaluation on consumer experience and prescription journey of diclofenac gel in Sweden
Authors: Nair Deepika , Norrefalk Jan-Rickard , Csoke Emese , Wilcox Teresa K. , Shanga Gilbert 
Published: August 2024

Abstract

Objectives
The aim of this study was to understand profiles of topical Voltaren gel diclofenac (VGD) 2.32 and 1.16% consumers through analyzing prescription patterns and to characterize treatment satisfaction, functional impairment, and pain relief after over-the-counter (OTC) VGD use in Sweden under real-world conditions.

Methods
This observational, real-world study conducted in Sweden had retrospective and prospective segments. The retrospective secondary data segment utilized 12-month diclofenac gel prescription data from the Swedish eHealth Agency (E-hälsomyndigheten). The prospective segment included electronic surveys completed at baseline and weeks 4 and 12 by adult consumers who purchased OTC VGD to treat their pain.

Results
Secondary data analyses (n = 12,145) showed that 56.7% of patients receiving diclofenac gel were females ≥70 years old. Most patients did not switch pain treatments; the mean time between diclofenac gel refills was about 2.5 months. From the surveys (n = 264), VGD provided pain relief, indicated by improvement in 11-point pain numeric rating scale scores. Average pain severity at baseline was 5.8 – improving by a mean of 1.3 and 1.9 points at weeks 4 and 12, respectively. The majority of consumers reported improvement in daily functioning (i.e., health-related quality of life [HRQoL]), and most were at least somewhat satisfied with VGD treatment results.

Conclusions
This real-world study provides important insights into the prescription patterns of diclofenac gel and the consumer experience with OTC VGD in Sweden. Patients rarely switched to other topical nonsteroidal anti-inflammatory drugs, and VGD consumers reported pain relief and improved HRQoL compared to baseline – resulting in treatment satisfaction.
Social Needs Screening Via Electronic Tablet in Pediatric Primary Care
Authors: Gorecki Michelle C. , Klein Melissa D. , Anyigbo Chidiogo U. , Beck Andrew F. , Henize Adrienne W. , Ehrlich Shelley R. , MacDougall Melinda C. , Burkhardt Mary Carol 
Published: August 2024

OBJECTIVES
(1) Assess whether health-related social needs (HRSN)/caregiver mental health concerns (CMHC) disclosure rates differ when screening questions are administered on paper versus electronic tablet. (2) Evaluate whether changes in need identification alters referral rates to social work and our medical-legal partnership (MLP).

METHODS
We conducted a retrospective review of HRSN/CMHC screening in publicly insured patients 0-18 years presenting for well-child visits in three primary care practices. Our primary outcome was HRSN/CMHC disclosure rate, comparing the proportion of positive HRSN/CMHC screens during the 11 months before and after screening modality change. Generalized estimating equations and interrupted time series (ITS) were used to assess changes over time. Mediation analyses assessed the indirect effect of HRSN/CMHC disclosure during the electronic screening period on changes in referrals to social work/MLP.

RESULTS
A total of 16,151 patients had paper-based HRSN/CMHC screens; 13,019 patients had electronic screens. Overall, 11% of paper-based screens identified ≥1 need, compared to 26% of electronic screens (p&lt;0.001). All three practices saw an increase in disclosure rate after transition from paper to electronic screening (odds ratio [OR] range 1.54 to 4.24). Using ITS, two of three practices had significantly increased odds of need disclosure with electronic screens compared to paper (OR 3.0, 95% confidence interval [CI] 2.5, 3.6; and OR 1.7, 95%CI 1.2, 2.4). Increased HRSN/CMHC disclosure rates from transitioning to electronic screening mediated increased referrals to social work/MLP.

CONCLUSIONS
Electronic screening was associated with an increased HRSN/CMHC disclosure rate compared to paper, which led to increased referrals to social work/MLP.
Коллективные иски в Европейском союзе: история развития и современное регулирование
Authors: Сутормин Никита Александрович 
Published: August 2024

Статья посвящена истории развития и современному состоянию института коллективного иска в праве Европейского союза и охватывает как основные источники его регулирования, действующие в настоящее время, так и связанные с ними подготовительные документы. Анализируя путь, пройденный институтом коллективного иска, автор приходит к выводу, что его положение в общей системе регулирования права ЕС заметно укрепляется, а возможности расширяются за счет включения новых областей регулирования и компенсаторных способов защиты. При этом коллективный иск в ЕС имеет уникальные черты, учитывающие правовые традиции государств-членов. Принятые итоговые документы заслуживают высокой оценки, но при этом все же дают поводы для критики и еще далеки от совершенства. В качестве положительных сторон сложившегося регулирования коллективных исков в ЕС обращает на себя внимание, что принятые Европейской комиссией директивы в целом отвечают европейскому правопорядку и учитывают реальные возможности отдельных государств-членов. В качестве прогрессивных шагов в области общего регулирования коллективных исков в ЕС в сфере защиты прав потребителей отмечается внедрение компенсаторных мер, гибкий механизм выбора формы участия истцов для государств-членов, внедрение информационных технологий оповещения и регистрации истцов. Вместе с тем автор критически оценивает саму модель организационного группового иска, выбранную в ЕС, и замечает, что не решенной по сути осталась проблема параллельных разбирательств. В заключительном разделе статьи на примере ФРГ кратко анализируется имплементация последней директивы ЕС в области представительских исков по потребительским спорам. Делается вывод о том, что подходы, выработанные в ЕС, имеют ценность для России как члена Евразийского экономического союза, поскольку международного регулирования коллективных процедур в рамках ЕАЭС не предусмотрено, а потребность в них, безусловно, есть.
The History Of Writing, Printing And Publishing The Holy Qur’an And Its Impact On The Arabic Language/ تاريخ كتابة المصحف الشريف وطباعته ونشره واثره في اللغة العربية
Authors: Al-Othman Fahd Bin Abdullah 
Published: August 2024

This research deals with the history of writing, printing, and publishing the Holy Qur’an and its impact on the Arabic language. The descriptive research seeks to explain the stages of development of writing the Holy Qur’an from the first eras of Islam until this era. The results: Fulfilling the promise of God Almighty to preserve His Book and protect it from subtraction, addition, and distortion, to maintain the Arabic language, as the Holy Qur’an was revealed in a clear Arabic language, to shed light on the historical transformations briefly, and how the Holy Qur’an was drawn into publishing the Holy Qur’an in the Kingdom of Saudi Arabia before and after its establishment. Efforts to maintain the distribution of Quranic manuscripts have a direct impact on the spread of the Arabic language worldwide.
Perceived hedonic values affecting students’ satisfaction and repurchase intention at SMEs retailers in Lephalale, South Africa
Authors: Briedenhann Scharl , Makhitha KM 
Published: August 2024

Research on students as consumers has garnered significant attention from researchers. This interest stems from the growing budgets allocated to students by both government and private families. Consequently, students engage in purchasing products and services from retailers both large and small (SMEs). To attract, satisfy and retain student customers, retailers must explore effective strategies. Hedonic values play a crucial role in retail marketing, especially when targeting students. This study aimed to assess the impact of perceived hedonic values on students’ satisfaction and repurchase intentions. Additionally, it investigated whether student satisfaction mediates the relationship between hedonic values an repurchase intentions. The survey was conducted among TVET college students in Lephalale, South Africa (SA). The findings could not exclusively confirm the effect of perceived hedonic values on students’ satisfaction and repurchase intentions. Similarly, the findings could not confirm the mediation effect of students’ satisfaction on the link between perceived hedonic values and repurchase intentions. The results are useful to SME retailers targeting student clientele.
Influence of valuable resources in performance of SMEs in Nairobi County
Authors: Mwaura Roselyn , Muchara Maina , Kangu Maureen 
Published: August 2024

Abstract
Resources and capabilities in SMEs are only advantageous when the SMEs have the potential to execute the right strategies and processes. SMEs must analyze their business environments and understand the resources available to operate efficiently and effectively and achieve a sustained performance. This study is the subject of the influence of valuable resources on performance of SMEs. This study used a cross-sectional survey design. The target population for this study comprised of 121, 680 SMEs. The research used stratified random sampling technique. The sample size of this study was 399 SMEs. A structured questionnaire was used to collect data. Findings showed that there was a positive significant correlation between valuable resource and SMEs performance (r=.270; p<.01). According to the linear regression analysis valuable resources account for 7.3% of SMEs performance. According to the regression coefficients, one-unit increase in valuable resources improved SMEs performance by 0.269 units (? = 0.269). The t-statistics results showed that t = 4.778, p<0.05. Therefore, there was enough evidence to reject the null hypothesis and conclude that valuable resources have a statistically significant influence on SMEs Performance. The study concluded that valuable resource has a significant relationship with SMEs Performance. Valuable resources have a statistically significant influence on SMEs Performance. Increasing valuable resources in an SMEs will help the enterprise register higher performance.
Key Words: Organizational Resources, Valuable Resources, Performance
The Impact of the Common Knowledge Construction Model (CKCM) Integrated with Ethnoscience and Podcasts on Science Process Skills in the Topic of Chemical Bonding
Authors: Nurlatifah Viki , Masykuri Mohammad , Ciptonugroho Wirawan , Yamtinah Sri , Ulfa Maria , Mulyani Bakti , Saputro Agung Nugroho Catur , Shidiq Ari Syahidul 
Published: August 2024

<span>Technological advances and competition in the 21st-century demand that students enhance their knowledge and skills. The Common Knowledge Construction Model (CKCM) can effectively influence students' academic skills and achievements in chemistry. This study examined the impact of CKCM integrated with ethnoscience and podcasts on improving science process skills and student learning outcomes. A quasi-experimental design with cluster random sampling was employed to select experimental and control groups from the population of specialization 11th-grade science program (five classes) in a senior high school in Boyolali Regency. Multiple-choice questions were used to measure science process skills and learning outcomes. Descriptive analysis and hypothesis testing were conducted using the Kruskal-Wallis test. The results revealed a significance value of 0.000 in both hypothesis tests for science process skills and learning outcomes. A significance value of less than 0.05 indicates that the application of CKCM positively impacts both variables. Integrating ethnoscience provides a deeper understanding by building culturally contextualized logical thinking. Supported by podcast media, it creates a dynamic and engaging learning environment that helps students actively construct their knowledge. This research contributes to developing the CKCM learning model mediated by podcasts to empower chemistry knowledge and science process skills, preparing students to meet the challenges of the 21st century.</span>
WITHDRAWN: Investigation of the anti-cancer drugs imatinib and thalidomide was conducted using analytical spectroscopy and molecular docking techniques
Authors: Ramana P. Venkata , Krishna Y. Rama , Mouli K. Chandra 
Published: August 2024

Abstract

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Expanding the concept of housekeeping genes: Examining the influence of retroelements on gene expression stability during cellular differentiation
Authors: Hong Seung-Jin , Park Hyeon-chun , Choi Haeyoun , Kim Sukil , Choi Jinyong , Oh Jung-Hwan , Rhyu Mun-Gan 
Published: August 2024

Abstract

Housekeeping genes (HKGs), essential for cellular differentiation, are traditionally thought to be uniformly expressed. However, recent analyses show variable expression across tissues, challenging this view. Identifying HKGs based on stable expression necessitates precise, repeated experiments. The limited number of transcription factors during differentiation suggests HKGs stabilise phenotypes via compensatory gene regulation. We examined retroelements, comprising approximately 40% of the human genome, for their influence on gene expression stability near transcriptional start sites (TSSs). By mapping CpG islands and retroelements within 10 kb of TSSs, we analysed 56 RNA sequencing datasets. CpG-island genes near Alu elements exhibited low expression variability, especially when the Alu elements were closer to the TSSs. Conversely, non-CpG island genes near L1 and LTR elements showed high variability, indicating distinct regulatory roles. Despite the constant number of Alu-adjacent CpG-island genes across tissues, their expression was most highly expressed in embryonic stem cells and declined in most differentiated tissues, except for an increase in the ovary and testis. Alu elements near CpG islands help stabilise phenotypes through compensatory downregulation of HKGs. These results expand the HKG concept to include genes maintaining stable phenotypes during differentiation, aiding in differentiation stage identification.
Risk evaluation of rockfall disaster in the cave entrance of western mountain railway tunnels based on the improved G1-EWM-UMT model
Authors: Dandan DANG , Li Gong , Jin Chunling , Qing Jun , Yang Tengteng , Jia Zhiyuan 
Published: August 2024

Abstract

To avoid the impact of rockfall on railroad safety, it is crucial to accurately predict the risk level of rockfall disaster in advance for the safe construction, operation, and maintenance of railroads. We take the western mountainous railroad tunnel opening as the research background and construct a western mountainous railroad tunnel opening rockfall disaster risk evaluation index system, including 15 core indexes and 6 alternative indexes. The unascertained measure theory (UMT) is chosen to evaluate the risk of rockfall disaster in tunnel openings. The improved G1 method and entropy weight method (EWM) are introduced to calculate the identify the risk of rockfall disaster based on the confidence level criterion. Furthermore, the criterion is used to recognize the risk level of a rockfall disaster. Ten typical tunnel openings of a railroad in the west are selected to validate engineering examples, and the evaluation results of the improved G1- EWM- UMT model are compared with those of the TOPSIS model (the technique for order preference by similarity to the ideal solution (TOPSIS)) and the actual rockfall situation in the project. The comparison results show that the accuracy of the improved G1- EWM- UMT model in evaluating the risk of rockfall is 90%, which is 30% higher than that of the TOPSIS model. This study has certain application value and engineering subjective and objective weights, and the UMT model and Lagrange optimal multiplier combination method are combined to significance, which provides a theoretical basis and technical reference to design the rockfall protection structure of western mountainous tunnels such as the Sichuan–Tibet railway under similar engineering geological conditions and proves the operability and applicability of the evaluation model.
Construction of an Urban Collaborative Emergency Response Network Based on a Disaster Chain: An Example of Typhoon Disaster in Fujian Province
Authors: Fu Boyi , Liang Xinyue , Wen Xin , Zhang Shuangbao , Cheng Quan 
Published: August 2024

Abstract

Disaster systems are both complex and chaotic; it is therefore important to conduct research on the interactions among functional organizations in an emergency collaborative governance network to improve a city's emergency management capability. This paper analyses the patterns of relationships among disaster response organizations in Fujian Province, China, based on historical case data of 14 typhoons from 1990 to 2023. Three indicators, namely, the centrality of organizational nodes, clustering coefficients, and core edges, were used to examine the characteristics of organizations. This paper then presents a disaster chain network and a model for a collaborative emergency response network in cities. The aim is to expand the analytical perspective on typhoon disasters by examining the relationship between the disaster chain and the organizational nodes. Results show that in response to typhoon disasters in Fujian Province, the government plays a central role while the Emergency Management Agency leads efforts to integrate resources from various departments. Therefore, this paper proposes three major synergistic mechanisms for early warning release, rescue and relief, and postdisaster reconstruction in response to typhoon disasters.
Causal Insights into Plasma Lipidome and Allergic Rhinitis: Implications from a Bidirectional Two-Sample Mendelian Randomization Analysis
Authors: Yang Haoxiang , Luo Yaxin , Liu Qiang 
Published: August 2024

Abstract

Plasma lipidomes regulate inflammatory responses and influence immune cell function, but the causal relationship between lipids and allergic rhinitis (AR) remains unclear. This study aimed to elucidate this relationship using Mendelian randomization (MR). Summary statistics were obtained from genome-wide association studies (GWAS) involving 179 plasma lipid subtypes and AR outcomes. Sensitivity analyses ensured robustness, heterogeneity, and absence of horizontal pleiotropy. Bayesian Weighted Mendelian Randomization (BWMR) was employed to enhance reliability. A meta-analysis further validated the findings. After FDR correction, several lipid phenotypes were identified as significant risk factors for AR, particularly phosphatidylcholine (18:0_20:4) levels, which remained significant using FinnGen data. Consistent results from MR Egger, weighted median, and BWMR methods underscored the robustness of our findings. This study suggests potential causal associations between specific plasma lipids and AR, offering new perspectives for exploring the biological mechanisms underlying AR and guiding the development of early intervention and treatment strategies.