bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitative Exploration of Sexual Experiences Among Adults on the Autism Spectrum: Implications for Sex Education
Authors: Barnett Jessica Penwell , Maticka‐Tyndale Eleanor 
Published: September 2015

CONTEXTThe increasing prevalence of autism since the 1990s has led to growing demand for sex education that meets the needs of persons on the autism spectrum. Yet there is a dearth of research documenting the firsthand experiences and perspectives of autistic individuals.METHODSA thematic analysis was conducted of in‐depth, Internet‐facilitated interviews with 24 adults on the autism spectrum who were recruited from Internet community spaces between November 2012 and May 2013. Inclusion criteria were self‐identification as a person on the autism spectrum, being a U.S. resident, being aged 18 or older, and having the ability to communicate orally or through writing.RESULTSParticipants were aged 18–61 and were living in the community at the time of interview, most with limited extrafamilial support. They were less likely than the general population to be heterosexual or gender‐conforming and were more likely to have experienced romantic or sexual debut after age 18. Participants’ most common concerns were courtship difficulties and sensory dysregulation in the context of partnered sexuality. These concerns were exacerbated by inadequate and inappropriate sex education experiences. Participants addressed challenges by using sensory barriers (e.g., latex gloves); planning when and how to have sex; negotiating alternatives to sexual scripts predicated on nondisabled experience; and practicing explicit and intentional communication.CONCLUSIONSIndividuals on the autism spectrum would benefit from sex education that normalizes differences (e.g., in identities and experiences of sexuality), is offered throughout young adulthood, addresses disability‐relevant sensory and communication needs, and includes practicing neurotypical sociosexual norms.
The Umbral operator and the integration
involving generalized Bessel-type functions
Authors: Nisar Kottakkaran Sooppy , Mondal Saiful Rahman , Agarwal Praveen , Al-Dhaifallah Mujahed 
Published: September 2015

Abstract
The main purpose of this paper is to introduce a class of new integrals involving generalized Bessel
functions and generalized Struve functions by using operational method and umbral formalization of Ramanujan
master theorem. Their connections with trigonometric functions with several distinct complex arguments are also
presented.
On the numerical solutions of some fractional ordinary differential equations by fractional Adams-Bashforth-Moulton method
Authors: Baskonus Haci Mehmet , Bulut Hasan 
Published: September 2015

Abstract
In this paper, we apply the Fractional Adams-Bashforth-Moulton Method for obtaining the numerical solutions of some linear and nonlinear fractional ordinary differential equations. Then, we construct a table including numerical results for both fractional differential equations. Then, we draw two dimensional surfaces of numerical solutions and analytical solutions by considering the suitable values of parameters. Finally, we use the L2 nodal norm and L∞ maximum nodal norm to evaluate the accuracy of method used in this paper.
Safety, pharmacokinetic and pharmacodynamic properties of TV-1106, a long-acting GH treatment for GH deficiency
Authors: Cohen-Barak Orit , Sakov Anat , Rasamoelisolo Michele , Bassan Merav , Brown Kurt , Mendzelevski Boaz , Spiegelstein Ofer 
Published: September 2015

BackgroundTV-1106 (Teva Pharmaceuticals) is a genetically fused recombinant protein of human GH (hGH) and human serum albumin, in development for treatment of GH deficiency (GHD). TV-1106 is expected to have an extended duration of action compared to daily GH treatment and may enable a reduction in the frequency of injections and improve compliance and quality of life for adults and children requiring GHD therapy.ObjectiveTo assess the safety, local tolerability, pharmacokinetics and pharmacodynamics of TV-1106 following single s.c. injections in healthy male volunteers.MethodsSubjects (n=56) were assigned to one of seven ascending dose groups (3–100 mg) and received either a single dose of TV-1106 (n=6) or placebo (n=2) by s.c. injection.ResultsEighteen subjects reported 43 adverse effects (AEs), which were mild to moderate; no serious AEs (SAEs) occurred. In 50, 70 and 100 mg groups there were mild to moderate increases in heart rate and systolic blood pressure that significantly correlated with higher levels of IGF1. TV-1106 showed pharmacokinetic characteristics of a long-acting hGH as demonstrated by a terminal elimination half-life of 23–35 h, delayed time of peak concentration, and systemic levels seen up to 7 days after dosing. IGF1 levels increased in a dose-dependent manner, before reaching a plateau, with levels above baseline extending beyond 7 days post dose.ConclusionSingle administration of TV-1106 up to 100 mg was safe in healthy volunteers. Pharmacokinetics and pharmacodynamics support once-weekly administration in patients with GHD.
The Abundant Histone Chaperones Spt6 and FACT Collaborate to Assemble, Inspect, and Maintain Chromatin Structure in Saccharomyces cerevisiae
Authors: McCullough Laura , Connell Zaily , Petersen Charisse , Formosa Tim 
Published: September 2015

Abstract
Saccharomyces cerevisiae Spt6 protein is a conserved chromatin factor with several distinct functional domains, including a natively unstructured 30-residue N-terminal region that binds competitively with Spn1 or nucleosomes. To uncover physiological roles of these interactions, we isolated histone mutations that suppress defects caused by weakening Spt6:Spn1 binding with the spt6-F249K mutation. The strongest suppressor was H2A-N39K, which perturbs the point of contact between the two H2A-H2B dimers in an assembled nucleosome. Substantial suppression also was observed when the H2A-H2B interface with H3-H4 was altered, and many members of this class of mutations also suppressed a defect in another essential histone chaperone, FACT. Spt6 is best known as an H3-H4 chaperone, but we found that it binds with similar affinity to H2A-H2B or H3-H4. Like FACT, Spt6 is therefore capable of binding each of the individual components of a nucleosome, but unlike FACT, Spt6 did not produce endonuclease-sensitive reorganized nucleosomes and did not displace H2A-H2B dimers from nucleosomes. Spt6 and FACT therefore have distinct activities, but defects can be suppressed by overlapping histone mutations. We also found that Spt6 and FACT together are nearly as abundant as nucleosomes, with ∼24,000 Spt6 molecules, ∼42,000 FACT molecules, and ∼75,000 nucleosomes per cell. Histone mutations that destabilize interfaces within nucleosomes therefore reveal multiple spatial regions that have both common and distinct roles in the functions of these two essential and abundant histone chaperones. We discuss these observations in terms of different potential roles for chaperones in both promoting the assembly of nucleosomes and monitoring their quality.
Development of the Children With Disabilities Algorithm
Authors: Chien Alyna T. , Kuhlthau Karen A. , Toomey Sara L. , Quinn Jessica A. , Houtrow Amy J. , Kuo Dennis Z. , Okumura Megumi J. , Van Cleave Jeanne M. , Johnson Chelsea K. , Mahoney Lindsey L. , Martin Julia , Landrum Mary Beth , Schuster Mark A. 
Published: September 2015

BACKGROUND:
A major impediment to understanding quality of care for children with disabilities (CWD) is the lack of a method for identifying this group in claims databases. We developed the CWD algorithm (CWDA), which uses International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes to identify CWD.

METHODS:
We conducted a cross-sectional study that (1) ensured each of the 14 567 codes within the 2012 ICD-9-CM codebook was independently classified by 3 to 9 pediatricians based on the code’s likelihood of indicating CWD and (2) triangulated the resulting CWDA against parent and physician assessment of children’s disability status by using survey and chart abstraction, respectively. Eight fellowship-trained general pediatricians and 42 subspecialists from across the United States participated in the code classification. Parents of 128 children from a large, free-standing children’s hospital participated in the parent survey; charts of 336 children from the same hospital were included in the abstraction study.

RESULTS:
CWDA contains 669 ICD-9-CM codes classified as having a ≥75% likelihood of indicating CWD. Examples include 318.2 Profound intellectual disabilities and 780.72 Functional quadriplegia. CWDA sensitivity was 0.75 (95% confidence interval 0.63–0.84) compared with parent report and 0.98 (0.95–0.99) compared with physician assessment; its specificity was 0.86 (0.72–0.95) and 0.50 (0.41–0.59), respectively.

CONCLUSIONS:
ICD-9-CM codes can be classified by their likelihood of indicating CWD. CWDA triangulates well with parent report and physician assessment of child disability status. CWDA is a new tool that can be used to assess care quality for CWD.
Chronic Pain Assessment Tools for Cerebral Palsy: A Systematic Review
Authors: Kingsnorth Shauna , Orava Taryn , Provvidenza Christine , Adler Ellie , Ami Noam , Gresley-Jones Tessa , Mankad Deepali , Slonim Naomi , Fay Linda , Joachimides Nick , Hoffman Andrea , Hung Ryan , Fehlings Darcy 
Published: September 2015

BACKGROUND AND OBJECTIVE:Chronic pain in children with cerebral palsy (CP) is underrecognized, leading to detriments in their physical, social, and mental well-being. Our objective was to identify, describe, and critique pediatric chronic pain assessment tools and make recommendations for clinical use for children with CP. Secondly, develop an evidence-informed toolbox to support clinicians in the assessment of chronic pain in children with disabilities.METHODS:Ovid Medline, Cumulative Index to Nursing and Allied Health Literature, and Embase databases were systematically searched by using key terms “chronic pain” and “clinical assessment tool” between January 2012 and July 2014. Tools from multiple pediatric health conditions were explored contingent on inclusion criteria: (1) children 1 to 18 years; (2) assessment focus on chronic pain; (3) psychometric properties reported; (4) written in English between 1980 and 2014. Pediatric chronic pain assessment tools were extracted and corresponding validation articles were sought for review. Detailed tool descriptions were composed and each tool underwent a formal critique of psychometric properties and clinical utility.RESULTS:Of the retrieved 2652 articles, 250 articles met eligibility, from which 52 chronic pain assessment tools were retrieved. A consensus among interprofessional working group members determined 7 chronic pain interference tools to be of importance. Not all tools have been validated with children with CP nor is there 1 tool to meet the needs of all children experiencing chronic pain.CONCLUSIONS:This study has systematically reviewed and recommended, through expert consensus, valid and reliable chronic pain interference assessment tools for children with disabilities.
Preterm Infant Attendance at Health Supervision Visits
Authors: D’Agostino Jo Ann , Passarella Molly , Saynisch Philip , Martin Ashley E. , Macheras Michelle , Lorch Scott A. 
Published: September 2015

OBJECTIVES:To assess the adherence of premature infants with the American Academy of Pediatrics health supervision visit schedule, factors affecting adherence, and the association of adherence with preventive care.METHODS:Retrospective cohort of all infants ≤35 weeks’ gestation, born 2005 to 2009, receiving care at a 30-site primary care network for at least 24 months (n = 1854). Adherence was defined as having a health supervision visit within each expected time period during the first 18 months of life. Logistic regression identified sociodemographic and medical factors associated with nonadherence and risk-adjusted association between nonadherence and outcomes.RESULTS:Only 43% received all expected health supervision visits. Those with Medicaid insurance (adjusted odds ratio [AOR] 0.46, 95% confidence interval [CI] 0.35–0.60), a visit without insurance (AOR 0.46, 95% CI 0.32–0.67), chronic illness (AOR 0.7, 95% CI 0.51–0.97), and black race (AOR 0.7, 95% CI 0.50–0.98) were less adherent, whereas provider continuity of care (AOR 2.89, 95% CI 1.92–4.37) and lower birth weight (AOR 1.67, 95% CI 1.02–2.73) increased adherence. Infants &lt;100% adherent were less likely to be up to date with immunizations and receive recommended preventive care. In nearly half of missed visit windows, no health supervision visit was scheduled.CONCLUSIONS:Fewer than half of premature infants were fully adherent with the preventive health schedule with associated gaps in health monitoring and immunization delays. These data suggest the importance of health supervision visits and the need to explore scheduling facilitators for those at risk for nonadherence.
Bladder Function After Fetal Surgery for Myelomeningocele
Authors: Brock John W. , Carr Michael C. , Adzick N. Scott , Burrows Pamela K. , Thomas John C. , Thom Elizabeth A. , Howell Lori J. , Farrell Jody A. , Dabrowiak Mary E. , Farmer Diana L. , Cheng Earl Y. , Kropp Bradley P. , Caldamone Anthony A. , Bulas Dorothy I. , Tolivaisa Susan , Baskin Laurence S. ,   for the MOMS Investigators
Published: September 2015

BACKGROUND:
A substudy of the Management of Myelomeningocele Study evaluating urological outcomes was conducted.

METHODS:
Pregnant women diagnosed with fetal myelomeningocele were randomly assigned to either prenatal or standard postnatal surgical repair. The substudy included patients randomly assigned after April 18, 2005. The primary outcome was defined in their children as death or the need for clean intermittent catheterization (CIC) by 30 months of age characterized by prespecified criteria. Secondary outcomes included bladder and kidney abnormalities observed by urodynamics and renal/bladder ultrasound at 12 and 30 months, which were analyzed as repeated measures.

RESULTS:
Of the 115 women enrolled in the substudy, the primary outcome occurred in 52% of children in the prenatal surgery group and 66% in the postnatal surgery group (relative risk [RR]: 0.78; 95% confidence interval [CI]: 0.57–1.07). Actual rates of CIC use were 38% and 51% in the prenatal and postnatal surgery groups, respectively (RR: 0.74; 95% CI: 0.48–1.12). Prenatal surgery resulted in less trabeculation (RR: 0.39; 95% CI: 0.19–0.79) and fewer cases of open bladder neck on urodynamics (RR: 0.61; 95% CI: 0.40–0.92) after adjustment by child’s gender and lesion level. The difference in trabeculation was confirmed by ultrasound.

CONCLUSIONS:
Prenatal surgery did not significantly reduce the need for CIC by 30 months of age but was associated with less bladder trabeculation and open bladder neck. The implications of these findings are unclear now, but support the need for long-term urologic follow-up of patients with myelomeningocele regardless of type of surgical repair.
Short-term effects of scaling and root planing with or without adjunctive use of an essential-oil-based mouthwash in the treatment of periodontal inflammation in smokers
Authors: Alshehri Mohammad , Alshail Faisal , Alqahtani Sami H. , Aloriny Tawfeeg Saleh , Alsharif Abdulhakim , Kujan Omar 
Published: September 2015

Objective
The aim of the present short-term follow-up study was to assess the effects of scaling and root planing (SRP) with or without adjunctive use of an essential-oil-based mouthwash in the treatment of periodontal inflammation in smokers.

Methods
In total, 120 individuals were divided into 2 groups. In Group-1, 60 smokers with periodontal inflammation received SRP alone; and in Grou p-2, 60 smokers with periodontal inflammation received adjunct essential-oil mouthwash therapy. Periodontal parameters (plaque index [PI], bleedingon- probing [BOP], and probing pocket depth [PD] ≥ 4 mm) were assessed at baseline and after 90 days of treatment.

Results
There was no significant difference in periodontal parameters (PI, BOP, and PD ≥ 4 mm) among participants in Group-1 and -2. Participants in both groups showed significant reductions in PI (P < 0.01), BOP (P < 0.01), and PD ≥ 4 mm (P < 0.01) at follow-up compared to base line. At 90 days of follow-up, PI (P < 0.05), BOP (P < 0.05), and PD ≥ 4 mm (P < 0.05) were significantly higher in Group-1 compared to Group-2.

Conclusions
SRP with adjunct essential-oil mouthwash therapy is more effective in the treatment o f periodontal inflammation in smokers as compared to when SRP is performed alone.
Effects of soybean milk, chitosan, and anti-Streptococcus mutans IgY in malnourished rats’ dental biofilm and the IgY persistency in saliva
Authors: Bachtiar Endang W. , Soejoedono Retno D. , Bachtiar Boy M. , Henrietta Alisya , Farhana Nur , Yuniastuti Mindya 
Published: September 2015

Objective
This study aims to evaluate the effect of soybean milk containing a combination of anti-Streptococcus mutans IgY and chitosan to the colonization of S. mutans in the saliva and to the IgY persistency in the saliva.

Materials and Methods
Experimental malnourished Sprague-Dawley rats were fed with soybean milk that is enriched with anti-S. mutans IgY and chitosan. After 15 days of feeding, we evaluated the S. mutans in dental biofilm, in addition to the persistency level of anti-S. mutans IgY.

Results
The rats that received soybean milk supplemented with anti-S. mutans IgY had the lowest number of S. mutans colonies (p < 0.05). Anti-S. mutans IgY was detected in saliva after 15 days of feeding.

Conclusions
Soybean milk supplemented with anti-S. mutans IgY and chitosan could significantly reduce S. mutans biofilm, and the supplemented anti-S. mutans IgY persisted in these rats’ saliva following the feeding period.
Commentary on: Are we overpathologizing everyday life? A tenable blueprint for behavioral addiction research
Authors: Ko Chih-Hung , Yen Ju-Yu 
Published: September 2015

Background and Aims
The commentary aims to provide clarity to the article “Are we overpathologizing everyday life? A tenable blueprint for behavioral addiction research.”

Methods
We provide another viewpoint for the important issues of behavior addiction.

Result
The course of behavior addiction should be further studied. The criteria of withdrawal and tolerance of behavior addiction are ill-defined and need to be further evaluated.

Conclusions
The etiology, course, presentation, and functional impairment of behavior addiction should be validated by evidencebased data before being defined as a disorder.
Commentary on: Are we overpathologizing everyday life? A tenable blueprint for behavioral addiction research
Authors: Brevers Damien , Noel Xavier 
Published: September 2015

Background
This paper is a commentary to a debate article entitled: “Are we overpathologizing everyday life? A tenable blueprint for behavioral addiction research”, by Billieux et al. (2015).

Methods and aim
This brief response focused on the necessity to better characterize psychological and related neurocognitive determinants of persistent deleterious actions associated or not with substance utilization.

Results
A majority of addicted people could be driven by psychological functional reasons to keep using drugs, gambling or buying despite the growing number of related negative consequences. In addition, a non-negligible proportion of them would need assistance to restore profound disturbances in basic learning processes involved in compulsive actions.

Conclusions
The distinction between psychological functionality and compulsive aspects of addictive behaviors should represent a big step towards more efficient treatments.
Commentary on: Are we overpathologizing everyday life? A tenable blueprint for behavioral addiction research
Authors: Maraz Aniko , Király Orsolya , Demetrovics Zsolt 
Published: September 2015

Background and Aims
Survey-based studies often fail to take into account the predictive value of a test, in other words, the probability of a person having (or not having) the disease when scoring positive (or negative) on the given screening test.

Methods
We re-visited the theory and basic calculations of diagnostic accuracy.

Results
In general, the lower the prevalence the worse the predictive value is. When the disorder is relatively rare, a positive test finding is typically not useful in confirming its presence given the high proportion of false positive cases. For example, using the Compulsive Buying Scale (Faber & O’Guinn, 1992) three in four people classified as having compulsive buying disorder will in fact not have the disorder.

Conclusions
Screening tests are limited to serve as an early detection “gate” and only clinical (interview-based) studies are suitable to claim that a certain behaviour is truly “pathological”.
Prevalence and co-occurrence of addictive behaviors among former alternative high school youth: A longitudinal follow-up study
Authors: Sussman Steve , Pokhrel Pallav , Sun Ping , Rohrbach Louise A. , Spruijt-Metz Donna 
Published: September 2015

Background and Aims
Recent work has studied addictions using a matrix measure, which taps multiple addictions through single responses for each type. This is the first longitudinal study using a matrix measure.

Methods
We investigated the use of this approach among former alternative high school youth (average age = 19.8 years at baseline; longitudinal n = 538) at risk for addictions. Lifetime and last 30-day prevalence of one or more of 11 addictions reviewed in other work was the primary focus (i.e., cigarettes, alcohol, hard drugs, shopping, gambling, Internet, love, sex, eating, work, and exercise). These were examined at two time-points one year apart. Latent class and latent transition analyses (LCA and LTA) were conducted in Mplus.

Results
Prevalence rates were stable across the two time-points. As in the cross-sectional baseline analysis, the 2-class model (addiction class, non-addiction class) fit the data better at follow-up than models with more classes. Item-response or conditional probabilities for each addiction type did not differ between time-points. As a result, the LTA model utilized constrained the conditional probabilities to be equal across the two time-points. In the addiction class, larger conditional probabilities (i.e., 0.40–0.49) were found for love, sex, exercise, and work addictions; medium conditional probabilities (i.e., 0.17–0.27) were found for cigarette, alcohol, other drugs, eating, Internet and shopping addiction; and a small conditional probability (0.06) was found for gambling.

Discussion and Conclusions
Persons in an addiction class tend to remain in this addiction class over a one-year period.