bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Updated Review of Medicinal Uses and Protective Activities of
Capparis Spinosa
Authors: Mahmoodpoor Fariba , Ahmadian Elham , Khavasi Narjes , Ardalan Mohammadreza , Zununi Vahed Sepideh , Nazemiyeh Hossein 
Published: July 2024

Abstract::
It is known that the cause of most diseases is oxidative stress. From the past, up to
today, plants have had important roles in the prevention and treatment of diseases due to high
amounts of bioactive and antioxidative contents. Over the last centuries, Capparis spinosa, a
plant species belonging to the genus Capparicedea, has been widely examined for several therapeutic
effects, including anti-microbial, anti-cancer activity, as well as anti-diabetic, renal, and
hepatoprotective properties in vitro and in vivo and some clinical trials. The presence of high
amounts of active components such as phenols and flavonoids in Capparis spinosa has turned it
into a potential valuable therapeutical agent since the trend in natural products and phytotherapy
has witnessed an increasing momentum in the realm of pharmaceutical sciences. Although this
plant has an intensive history in traditional medicine, more studies are required to gain in-depth
comprehensive knowledge of its potential clinical effects and mechanisms. This review aims to
summarize the protective and therapeutic activities of Capparis spinosa and the possible prospects
of its biomedical applications. New technology methods like nanoparticles are recommended.
Role of Metalloproteinases in Diabetes-associated Mild Cognitive Impairment
Authors: Pereira Vitoria Mattos , Pradhanang Suyasha , Prather Jonathan F. , Nair Sreejayan 
Published: July 2024

:
Diabetes has been linked to an increased risk of mild cognitive impairment (MCI), a condition
characterized by a subtle cognitive decline that may precede the development of dementia. The
underlying mechanisms connecting diabetes and MCI involve complex interactions between metabolic
dysregulation, inflammation, and neurodegeneration. A critical mechanism implicated in diabetes and
MCI is the activation of inflammatory pathways. Chronic low-grade inflammation, as observed in diabetes,
can lead to the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha
(TNF-α), interleukin-6 (IL-6), interleukin-1 beta (IL-1β), and interferon-gamma (IFNγ), each of which
can exacerbate neuroinflammation and contribute to cognitive decline. A crucial enzyme involved in
regulating inflammation is ADAM17, a disintegrin, and metalloproteinase, which can cleave and release
TNF-α from its membrane-bound precursor and cause it to become activated. These processes, in
turn, activate additional inflammation-related pathways, such as AKT, NF-κB, NLP3, MAPK, and
JAK-STAT pathways. Recent research has provided novel insights into the role of ADAM17 in diabetes
and neurodegenerative diseases. ADAM17 is upregulated in both diabetes and Alzheimer's disease,
suggesting a shared mechanism and implicating inflammation as a possible contributor to much
broader forms of pathology and pointing to a possible link between inflammation and the emergence
of MCI. This review provides an overview of the different roles of ADAM17 in diabetes-associated
mild cognitive impairment diseases. It identifies mechanistic connections through which ADAM17
and associated pathways may influence the emergence of mild cognitive impairment.
Immersive and Nonimmersive Virtual Reality–Assisted Active Training in Chronic Musculoskeletal Pain: Systematic Review and Meta-Analysis
Authors: Lo Hermione Hin Man , Zhu Mengting , Zou Zihui , Wong Cho Lee , Lo Suzanne Hoi Shan , Chung Vincent Chi-Ho , Wong Samuel Yeung-Shan , Sit Regina Wing Shan 
Published: July 2024

Background
Virtual reality (VR) in different immersive conditions has been increasingly used as a nonpharmacological method for managing chronic musculoskeletal pain.

Objective
We aimed to assess the effectiveness of VR-assisted active training versus conventional exercise or physiotherapy in chronic musculoskeletal pain and to analyze the effects of immersive versus nonimmersive VR on pain outcomes.

Methods
This systematic review of randomized control trials (RCTs) searched PubMed, Scopus, and Web of Science databases from inception to June 9, 2024. RCTs comparing adults with chronic musculoskeletal pain receiving VR-assisted training were included. The primary outcome was pain intensity; secondary outcomes included functional disability and kinesiophobia. Available data were pooled in a meta-analysis. Studies were graded using the Cochrane Risk-of-Bias Tool version 2.

Results
In total, 28 RCTs including 1114 participants with some concerns for a high risk of bias were identified, and 25 RCTs were included in the meta-analysis. In low back pain, short-term outcomes measured post intervention showed that nonimmersive VR is effective in reducing pain (standardized mean difference [SMD] –1.79, 95% CI –2.72 to –0.87; P<.001), improving disability (SMD –0.44, 95% CI –0.72 to –0.16; P=.002), and kinesiophobia (SMD –2.94, 95% CI –5.20 to –0.68; P=.01). Intermediate-term outcomes measured at 6 months also showed that nonimmersive VR is effective in reducing pain (SMD –8.15, 95% CI –15.29 to –1.01; P=.03), and kinesiophobia (SMD –4.28, 95% CI –8.12 to –0.44; P=.03) compared to conventional active training. For neck pain, immersive VR reduced pain intensity (SMD –0.55, 95% CI –1.02 to –0.08; P=.02) but not disability and kinesiophobia in the short term. No statistical significances were detected for knee pain or other pain regions at all time points. In addition, 2 (8%) studies had a high risk of bias.

Conclusions
Both nonimmersive and immersive VR–assisted active training is effective in reducing back and neck pain symptoms. Our study findings suggest that VR is effective in alleviating chronic musculoskeletal pain.

Trial Registration
PROSPERO CRD42022302912; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=302912
Rest-Activity Rhythm Differences in Acute Rehabilitation Between Poststroke Patients and Non–Brain Disease Controls: Comparative Study
Authors: Liang Huey-Wen , Wu Chueh-Hung , Lin Chen , Chang Hsiang-Chih , Lin Yu-Hsuan , Chen Shao-Yu , Hsu Wei-Chen 
Published: July 2024

Background
Circadian rhythm disruptions are a common concern for poststroke patients undergoing rehabilitation and might negatively impact their functional outcomes.

Objective
Our research aimed to uncover unique patterns and disruptions specific to poststroke rehabilitation patients and identify potential differences in specific rest-activity rhythm indicators when compared to inpatient controls with non–brain-related lesions, such as patients with spinal cord injuries.

Methods
We obtained a 7-day recording with a wearable actigraphy device from 25 poststroke patients (n=9, 36% women; median age 56, IQR 46-71) and 25 age- and gender-matched inpatient control participants (n=15, 60% women; median age 57, IQR 46.5-68.5). To assess circadian rhythm, we used a nonparametric method to calculate key rest-activity rhythm indicators—relative amplitude, interdaily stability, and intradaily variability. Relative amplitude, quantifying rest-activity rhythm amplitude while considering daily variations and unbalanced amplitudes, was calculated as the ratio of the difference between the most active 10 continuous hours and the least active 5 continuous hours to the sum of these 10 and 5 continuous hours. We also examined the clinical correlations between rest-activity rhythm indicators and delirium screening tools, such as the 4 A’s Test and the Barthel Index, which assess delirium and activities of daily living.

Results
Patients who had a stroke had higher least active 5-hour values compared to the control group (median 4.29, IQR 2.88-6.49 vs median 1.84, IQR 0.67-4.34; P=.008). The most active 10-hour values showed no significant differences between the groups (stroke group: median 38.92, IQR 14.60-40.87; control group: median 31.18, IQR 18.02-46.84; P=.93). The stroke group presented a lower relative amplitude compared to the control group (median 0.74, IQR 0.57-0.85 vs median 0.88, IQR 0.71-0.96; P=.009). Further analysis revealed no significant differences in other rest-activity rhythm metrics between the two groups. Among the patients who had a stroke, a negative correlation was observed between the 4 A’s Test scores and relative amplitude (ρ=–0.41; P=.045). Across all participants, positive correlations emerged between the Barthel Index scores and both interdaily stability (ρ=0.34; P=.02) and the most active 10-hour value (ρ=0.42; P=.002).

Conclusions
This study highlights the relevance of circadian rhythm disruptions in poststroke rehabilitation and provides insights into potential diagnostic and prognostic implications for rest-activity rhythm indicators as digital biomarkers.
Collaborative Human–Computer Vision Operative Video Analysis Algorithm for Analyzing Surgical Fluency and Surgical Interruptions in Endonasal Endoscopic Pituitary Surgery: Cohort Study
Authors: Wong Chia-En , Chen Pei-Wen , Hsu Heng-Jui , Cheng Shao-Yang , Fan Chen-Che , Chen Yen-Chang , Chiu Yi-Pei , Lee Jung-Shun , Liang Sheng-Fu 
Published: July 2024

Background
The endonasal endoscopic approach (EEA) is effective for pituitary adenoma resection. However, manual review of operative videos is time-consuming. The application of a computer vision (CV) algorithm could potentially reduce the time required for operative video review and facilitate the training of surgeons to overcome the learning curve of EEA.

Objective
This study aimed to evaluate the performance of a CV-based video analysis system, based on OpenCV algorithm, to detect surgical interruptions and analyze surgical fluency in EEA. The accuracy of the CV-based video analysis was investigated, and the time required for operative video review using CV-based analysis was compared to that of manual review.

Methods
The dominant color of each frame in the EEA video was determined using OpenCV. We developed an algorithm to identify events of surgical interruption if the alterations in the dominant color pixels reached certain thresholds. The thresholds were determined by training the current algorithm using EEA videos. The accuracy of the CV analysis was determined by manual review, and the time spent was reported.

Results
A total of 46 EEA operative videos were analyzed, with 93.6%, 95.1%, and 93.3% accuracies in the training, test 1, and test 2 data sets, respectively. Compared with manual review, CV-based analysis reduced the time required for operative video review by 86% (manual review: 166.8 and CV analysis: 22.6 minutes; P<.001). The application of a human-computer collaborative strategy increased the overall accuracy to 98.5%, with a 74% reduction in the review time (manual review: 166.8 and human-CV collaboration: 43.4 minutes; P<.001). Analysis of the different surgical phases showed that the sellar phase had the lowest frequency (nasal phase: 14.9, sphenoidal phase: 15.9, and sellar phase: 4.9 interruptions/10 minutes; P<.001) and duration (nasal phase: 67.4, sphenoidal phase: 77.9, and sellar phase: 31.1 seconds/10 minutes; P<.001) of surgical interruptions. A comparison of the early and late EEA videos showed that increased surgical experience was associated with a decreased number (early: 4.9 and late: 2.9 interruptions/10 minutes; P=.03) and duration (early: 41.1 and late: 19.8 seconds/10 minutes; P=.02) of surgical interruptions during the sellar phase.

Conclusions
CV-based analysis had a 93% to 98% accuracy in detecting the number, frequency, and duration of surgical interruptions occurring during EEA. Moreover, CV-based analysis reduced the time required to analyze the surgical fluency in EEA videos compared to manual review. The application of CV can facilitate the training of surgeons to overcome the learning curve of endoscopic skull base surgery.

Trial Registration
ClinicalTrials.gov NCT06156020; https://clinicaltrials.gov/study/NCT06156020
Screening Lung Cancer in Sampang Regency, Madura Through Empowerment and Health Cadres Formation
Authors: Yudhawati Resti , Wulandari Laksmi , Febriani Anna , Wati Farah Fatma , Thendeyas Richar Tomy , Atik Nurul , Hariputri Wulan Rahmawati , Novananda Donny Ardika , Riyanto Shandy Billy 
Published: July 2024

Treatment for lung cancer remains challenging since most of the patients seek medical advice at an advanced stage of disease. Sampang is one of the regencies that refers many lung cancer patients in late stages to Dr. Soetomo Hospital, Surabaya, due to lack of information of lung cancer and early detection. Limited number of health workers to deliver comprehensive education to all areas requires community volunteers to fill this gap. The objective of this study was to educate and promote lung cancer awareness to the health cadres in Sampang as well as training them to early detecting individuals in the community with high-risk factors, as an attempt to bridge between the health workers and community, therefore the number of lung cancer early detection may be improved. Early identification of cancer may result in reduced morbidity and mortality, and in some cases, if detected early enough, therapy may involve only surgery. The education was provided for the health cadres by providing information related to lung cancer and guidance to fill the questionnaire and scoring of lung cancer risk factors. The participants' understanding was measured using a pretest-posttest design. Thirty health cadres have been successfully formed, and they have gained knowledge of lung cancer and mastered capability to perform early-screening of lung cancer in the community as shown by the increase of post-test result compared to pre-test. The health cadres then implemented their knowledge of lung cancer early-screening by distributing questionnaires of lung cancer risk factor scoring to residents using door to door methods. The questionnaires’ evaluation collected by the health cadres showed that there were 93 residents with high-risk factors of lung cancer. In conclusion, the health cadres has been capable to detect high-risk factors individuals in the community which further be followed up by community health workers comprehensively.
Kontribusi Virtual Tour Terhadap Pembentukan Citra Afektif Destinasi Wisata di Daerah Istimewa Yogyakarta Selama Masa Pandemi COVID-19
Authors: Pradana Cerry Surya , Rohani Elisa Dwi , Yudhistira Alfian William , Safitri Sukma Suci 
Published: July 2024

Pandemi Covid-19 yang melanda seluruh dunia, menyebabkan penyesuaian pada berbagai macam kegiatan, termasuk dalam bidang pariwisata. Yogyakarta merupakan salah satu daerah tujuan wisata yang terkena dampak pandemi tersebut. Beberapa penyesuaian yang dibuat, misalnya dengan adanya penutupan sementara destinasi wisata, pembatasan kunjungan, hingga penerapan protokol kesehatan pada seluruh aktivitas. Terbatasnya akses bagi wisatawan, menjadi hal yang berdampak besar baik bagi keberlangsungan pariwisata di destinasi ini. Penelitian ini bertujuan untuk melihat dan memahami persepsi wisatawan terhadap citra afektif destinasi wisata yang ada di Yogyakarta, baik yang pernah maupun belum pernah mengunjungi destinasi ini. Data dikumpulkan melalui observasi, wawancara menggunakan kuisioner, dan studi pustaka. Observasi dilakukan pada aktivitas terkini yang ada di beberapa platform virtual tour. Wawancara dilakukan menggunakan sampel secara convenience sampling, pada 141 orang responden yang telah mengikuti virtual tour. Kuesioner diberikan dalam bentuk daring, yang disajikan dalam google form. Pustaka terkait dengan citra afektif juga digunakan untuk menyiapkan tahapan analisis. Hasil yang diharapkan, penelitian ini mampu menunjukkan persepsi wisatawan terhadap citra afektif di Daerah Istimewa Yogyakarta, selama masa pandemi Covid-19. Penelitian ini memiliki keterbatasan, dikarenakan hanya melihat dari citra afektif tanpa melanjutkannya dengan citra kognitif. Oleh karena itu, dibutuhkan penelitian lainnya yang berkaitan dengan citra kognitif dengan tema yang sama.
Aprendizaje basado en proyectos en el abordaje de los Juegos Olímpicos Tokio 2020: Una experiencia interdisciplinar
Authors: Añazco Martinez Luis Alfredo 
Published: July 2024

El trabajo colaborativo entre docentes permite abordar experiencias de aprendizaje innovadoras que faculten el uso de las tecnologías educativas de forma interdisciplinar. Es así como realizar actividades orientadas a un currículum basado en las competencias permite trabajar metodologías activas como el aprendizaje basado en proyectos (ABP) y el uso de la evaluación formativa. Por lo tanto, el objetivo de la experiencia educativa es presentar el proyecto de aula interdisciplinar, por medio del tema de los Juegos Olímpicos, siendo la asignatura de Educación Física base para abordar el ABP. Para ello, las personas docentes han generado reuniones de trabajo en Google Meet ® por medio del desarrollo de una planificación donde participan todas las asignaturas y el equipo multidisciplinario en el curso de Tercero Básico. El planteamiento del problema ha nacido del interés de estudiantes y las asignaturas ejes corresponden a Educación Física y Salud e Historia en apoyo de las demás. El proyecto durante su proceso utiliza la plataforma de Google Drive® para compartir las actividades del personal docente, el cual presenta sus estados de avances que son retroalimentados entre las mismas personas participantes Es así como el profesorado valoró de manera positiva trabajar de forma interdisciplinar con base en la metodología activa del ABP sobre un tema en común. Además, se destaca el uso de los entornos virtuales para trabajar las etapas del proyecto. Sin embargo, se requiere aumentar las experiencias basadas en metodologías activas.
Pesticide Residues Analysis of Arabica Coffee Bean from Community Coffee Plantation Manglayang Mountain, Bandung Regency
Authors: Rasiska Siska , Maharani Yani , Hutapea Dedi Hutapea , Maxiselly Yudithia , Wulandari Ela Hasri 
Published: July 2024

Coffee is one of the export commodities that has produced gross domestic product up to 16.15% of the agricultural sector. However, pesticide residues in agricultural products remain a barrier in the context of exports and agricultural product safety. The study aims to analyze the pesticide residue content in coffee produced by farmers at the Manglayang Mountain Community Coffee Plantation (CCP) compared to the maximum residue limit. The method used in this research is explorative descriptive by collecting samples from the Giri Senang Forest Community, Legok Nyenang-Giri Mekar Village, Cilengkrang District, Bandung Regency, and analyzed with the method EN 15662:2018. A kilogram of coffee is washed and dried for two days, then separated from the skin of the coffee and the green bean. The green bean are then extracted by QuEChERS, by adding 1% acetic acid in acetonitril and the extract is cleansed using high SPE dispersive. LC-ESI-MS/MS is operated in MRM mode, and validated according to the SANTE 12682/2019 requirements. The results of the research showed that the coffee from was not detected containing residues of pesticides from the organophosphate and carbamate groups. Thus, the coffee products from Manglayang Mountain CCP are considered safe to be consumed, and can be exported abroad.
Comparative Analysis of the Content of Combat Orders in the Yugoslav People’s Army and Operational Orders in the Serbian Armed Forces
Authors: Jovanović Miroslav , Kojić Mladen , Jotić Slaviša , Žnidaršič Vinko 
Published: July 2024

Abstract
This paper undertakes a comparative analysis of the content of combat orders in the Yugoslav People’s Army and operational orders in the Serbian Armed Forces. Utilizing methods of content analysis and comparative analysis, this study identifies key differences and similarities between the two documents, shedding light on their respective advantages and disadvantages. While both documents serve to provide guidance and direction to military units, they differ significantly in structure, language, and emphasis. The analysis reveals that certain points of combat orders correspond to specific points of operational orders in terms of content. However, the operational order offers a more comprehensive assessment of the enemy and places a greater emphasis on decentralized execution compared to the combat order. Notable differences include the level of detail provided, with Yugoslav People’s Army combat orders being more verbose and reflecting a centralized command structure, whereas Serbian Armed Forces orders prioritize brevity and clarity. Despite these disparities, both documents underscore the importance of mission accomplishment, personnel welfare, and adherence to legal and ethical standards. They also recognize the need for adaptability and flexibility in dynamic operational environments.
An Overview of the Most Effective Technical Means Used for Various Military Engineering Mission, with Highlights on Their Interoperability
Authors: Popescu Stelian 
Published: July 2024

Abstract
We could mention that currently we cannot speak, at the level of the NATO Alliance, of the existence of interoperability of engineering structures, from all partner armies, in terms of providing them with high-performance technical means, intended to ensure timely and efficient engineering support. This is based on the analysis we carried out on ensuring the interoperability of engineering structures participating in multinational missions and exercises, from the perspective of providing them with modern technical means, in order to fulfill the engineering support missions, after some exchanges with partners from Hungary, the Czech Republic, Slovakia and the multinational exercises that colonel Mircea VLADU led as director or co-director, between 2011 and 2013 in Romania, Hungary and Croatia. On these occasions, we were able to as certain that the engineering structures of the armies that were part of the Warsaw Treaty are predominantly equipped with technical engineering means from 80s, some purchased from the former USSR and others manufactured within their own defense industries, a situation that continued even after the integration of the respective states into NATO, as a result of the allocation of some percentages of the GDP, below the level of the commitments and at the same time the support with insufficient funds of the endowment proposals with efficient means, according to NATO standards. Considering these elements, we would like to further present some considerations aimed at equipping NATO engineering structures with the most efficient technical means for the execution of engineering research operations.
Analysis Regarding the Relationship Between the Leader and the Team Members in a Production Company in Romania
Authors: Miricescu Dan , Todăriţă Elida-Tomița 
Published: July 2024

Abstract
The organization is by nature a complex system based on the unity of a larger or smaller group of people who have a single common goal, namely the fulfillment of the main objectives of the organization through professional activities that lead to maximum efficiency in the shortest time and with long-term effects. In addition to this goal, we must add the creation of an optimal work environment, the creation of a favorable image, the creation of prestige, and last but not least the good coordination of leaders. Solving tasks at work becomes much easier when team members constantly collaborate with leaders. Therefore, the general objective of this study is to analyze the relationship between leaders and team members within an organization with a production profile in Romania. Thus, 12 people who occupy different management positions were chosen. A questionnaire based on a quantitative analysis was used as a working tool. It consisted of 20 questions (19 closed questions and one open-ended question). The questionnaire was distributed directly (online) using the Google Forms platform.