bluuebunny/crossref_metadata_2025_split huggingface dataset:
L'évolution des valeurs et ses implications en marketing : Une enquête en Russie
Authors: Aurifeille Jacques-Marie 
Published: March 2013

La Russie a été choisie pour étudier le processus d'évolution des valeurs terminales et instrumentales. De cette étude, à caractère essentiellement exploratoire, deux observations se dégagent: D'une part, la stabilité globale des systèmes de valeurs : la régression de certaines valeurs est compensée par la progression d'autres valeurs. Ceci pose la question de la pertinence des stratégies marketing, notamment « moyens-fins », fondées sur une unique valeur des consommateurs. D'autre part, on observe une plus grande stabilité des valeurs instrumentales que des valeurs terminales; par suite, il semble que plus d'attention devrait être accordée aux valeurs instrumentales quand des stratégies durables de segmentation et de positionnement sont recherchées.
Mode de diagnostic de marchés concurrentiels
Authors: Bultez Alain 
Published: March 2013

Cet article expose un modèle simple de la dynamique déterminant l'évolution des parts de marché. Leurs variations résultent du jeu d'attractions uniformément exercées par les divers concurrents sur les segments de consommateurs potentiels inconstants, aux rythmes d'achat distincts. Le diagnostic s'établit par comparaison des positions actuelles à celles dégagées d'un exercice de prévision conservatoire: l'extrapolation des tendances observées qui définit la redistribution du marché à laquelle on aboutirait à long terme, en cas de marchéage stationnaire. Dans un prochain article (Bultez, 1997), nous présenterons une généralisation de notre approche intégrant les effets des actions de marketing précisément entreprises pour amplifier ou contrecarrer les courants du moment. Du mode descriptif nous passerons alors à l'explicatif: de l'évaluation au contrôle.
Analyse de l'effet des messages publicitaires grâce au réseau d'associations
Authors: Kirchler Erich , de Rosa Annamaria Silvana 
Published: March 2013

L'objectif de cet article est, d'une part, la présentation du réseau d'associations comme une technique de recueil des représentations mentales et, d'autre part, la présentation de l'utilité de cette technique pour l'analyse de l'effet publicitaire au travers de l'exemple des affiches publicitaires de la société Benetton. Le réseau d'associations peut être compris comme une méthode projective. Des objets sont présentés aux participant(e)s et, immédiatement, des associations libres sont enregistrées grâce à un protocole de recueil. Ensuite, les associations sont classées par les participants eux-mêmes, en fonction de leur aspect positif, neutre ou négatif. L'ordre des associations est décrit et, finalement, des lignes de connexion sont dessinées entre les associations qui paraissent aller ensemble. 82 personnes en total ont évalué trois affiches publicitaires de la société Benetton. En utilisant le réseau d'associations, on montre de quelle façon les attitudes varient entre les affiches et quelles différences existent entre les associations qui ont été enregistrées immédiatement après la présentation et celles qui ont été recueillies après une observation plus longue des affiches. Les impressions négatives, surtout de deux affiches, permettent, grâce aux analyses, différentes conclusions concernant l'effet publicitaire.
Énoncé ou énonciation? deux objets différents de l'analye lexicale en marketing
Authors: Gavard-Perret Marie-Laure , Moscarola Jean 
Published: March 2013

Les auteurs proposent une relecture de l'analyse lexicale. Distinguant l'énoncé de l'énonciation, ils passent en revue différentes techniques en précisant les deux fonctions possibles de l'analyse lexicale: l'analyse descriptive ou l'approximation des contenus l'analyse interprétative ou la statistique des actes de langage. Ils les illustrent avec des exemples et en montrent l'intérêt pour le marketing.
Polymorphisms of Interleukin-1 Beta and Interleukin-17Alpha Genes Are Associated With Restless Legs Syndrome
Authors: Hennessy Mary Dawn , Zak Rochelle S. , Gay Caryl L. , Pullinger Clive R. , Lee Kathryn A. , Aouizerat Bradley E. 
Published: March 2013

Objective: Dopamine, iron, and inflammatory pathways are considered important to the development of restless legs syndrome (RLS). Recent genetic studies support involvement of dopamine and iron; however, cytokine gene variation in the inflammatory component remains unexplored. A recent study reported a high prevalence of RLS among HIV-infected adults. We estimate occurrence of RLS in an ethnically diverse sample of HIV-infected adults and examine differences in demographic factors, clinical characteristics, and biomarkers relating to dopamine, iron, and inflammation between adults with and without RLS symptoms. Design: A prospective longitudinal study aimed at identifying biomarkers of RLS symptom experience among HIV-infected adults. Method: 316 HIV-positive adults were evaluated using International RLS Study Group criteria. Genes were chosen for hypothesized relationships to dopamine ( NOS1, NOS2), iron ( HFE) or inflammation-mediated by cytokine genes (interferon [ IFN], interleukin [ IL], nuclear factor kappa-B [ NFKB], and tumor necrosis factor alpha [ TNFA]). Results: Similar to general population estimates, 11% of the sample met all four RLS diagnostic criteria. Controlling for race, gender, and hemoglobin, carrying two copies of the minor allele for IL1B rs1143643, rs1143634, or rs1143633 or carrying the minor allele for IL17A rs8193036 was associated with increased likelihood of meeting RLS diagnostic criteria. Conclusion: This study provides preliminary evidence of a genetic association between IL1B and IL17A genes and RLS.
Video self-modelling and its impact on the development of communication skills within social work education
Authors: Bolger Janine 
Published: March 2013

Summary This article describes the evaluation of a programme which utilised video self-modelling to develop communication skills and associated skills of reflection and self-assessment within social work education at the Robert Gordon University in Aberdeen, Scotland. Video self-modelling techniques were adopted utilising role-play scenarios, simulating situations commonly encountered in social work practice, with social work students prior to their first period of Practice Learning. Eleven participants were observed via video footage and independently rated according to the communication skills they displayed. Group discussion in conjunction with pre- and post-test questionnaires encouraged participants to reflect on their practice. Findings The greatest increase in the frequency of observations of desirable communication skills was most often achieved by participants who had scored the lowest in the rating of their skills during the pre-test videos. Overall there was no statistically significant difference between the pre- and post-tests scores with regard to the communication skills demonstrated. By contrast, all 11 participants expressed a belief that the majority of their skills had improved as a result of experiencing video self-modelling techniques which led to a greater level of reflective practice and growth in self-efficacy with regard to their professional competence. Applications This approach can be applied to measure the impact development of communication skills on social work courses.
Osteochondral Allografts in the Ankle Joint
Authors: Vannini Francesca , Buda Roberto , Pagliazzi Gherardo , Ruffilli Alberto , Cavallo Marco , Giannini Sandro 
Published: March 2013

Purpose: The aim of this systematic review is to report about the clinical use of partial and total fresh osteochondral allograft in the ankle joint. The state of the art of allografts with regard to basic science, procurement and storage methods, immunogenicity, generally accepted indications and contraindications, and the rationale of the allografting procedure have been described. Methods: All studies published in PubMed from 2000 to January 2012 addressing fresh osteochondral allograft procedures in the ankle joint were identified, including those that fulfilled the following criteria: (a) level I-IV evidence addressing the areas of interest outlined above; (b) measures of functional, clinical, or imaging outcome; and (c) outcome related to ankle cartilage lesions or ankle arthritis treated by allografts. Results: The analysis showed a progressively increasing number of articles from 2000. The number of selected articles was 14; 9 of those focused on limited dimension allografts (plugs, partial) and 5 on bipolar fresh osteochondral allografts. The evaluation of evidence level showed 14 case series and no randomized studies. Conclusions: Fresh osteochondral allografts are now a versatile and suitable option for the treatment of different degrees of osteochondral disease in the ankle joint and may even be used as total joint replacement. Fresh osteochondral allografts used for total joint replacement are still experimental and might be considered as a salvage procedure in otherwise unsolvable situations. A proper selection of the patients is therefore a key point. Moreover, the patients should be adequately informed about the possible risks, benefits, and alternatives to the allograft procedure.
Laparoscopy for extraperitoneal rectal cancer reduces short‐term morbidity: Results of a systematic review and meta‐analysis
Authors: Arezzo Alberto , Passera Roberto , Scozzari Gitana , Verra Mauro , Morino Mario 
Published: March 2013

BackgroundThe role of laparoscopy in the treatment of extraperitoneal rectal cancer is still controversial. The aim of the study was to evaluate differences in safety of laparoscopic rectal resection for extraperitoneal cancer, compared with open surgery.Materials and methodsA systematic review from 2000 to July 2012 was performed searching the MEDLINE and EMBASE databases (PROSPERO registration number CRD42012002406). We included randomized and prospective controlled clinical studies comparing laparoscopic and open resection for rectal cancer. Primary endpoints were 30‐day mortality and morbidity. Then a meta‐analysis was conducted by a fixed‐effect model, performing a sensitivity analysis by a random‐effect model. Relative risk (RR) was used as an indicator of treatment effect.ResultsEleven studies, representing 1684 patients, met the inclusion criteria: four were randomized for a total of 814 patients. Mortality was observed in 1.2% of patients in the laparoscopic group and in 2.3% of patients in the open group, with an RR of 0.56 (95% CI 0.19–1.64, p  = 0.287). The overall incidence of short‐term complications was lower in the laparoscopic group (31.5%) compared to the open group (38.2%), with an RR of 0.83 (95% CI 0.73–0.94, p  = 0.004). Surgical complications, wound complications, blood loss and the need for blood transfusion, time for bowel movement recovery, food intake recovery, and hospital stay were significantly lower or less frequent in the laparoscopic group. The incidence of intra‐operative injuries, anastomotic leakages, and surgical re‐interventions was similar in the two groups. Only operative time was in favour of the open group.ConclusionsBased on the evidence of both randomized and prospective controlled series, mortality was lower after laparoscopy although not significantly so, while the short‐term morbidity RR, including subgroup analysis, was significantly lower after laparoscopy for extraperitoneal rectal cancer compared to open surgery.
Primary mediastinal large B-cell lymphoma segregating in a family: exome sequencing identifies MLL as a candidate predisposition gene
Authors: Saarinen Silva , Kaasinen Eevi , Karjalainen-Lindsberg Marja-Liisa , Vesanen Kari , Aavikko Mervi , Katainen Riku , Taskinen Minna , Kytölä Soili , Leppä Sirpa , Hietala Marja , Vahteristo Pia , Aaltonen Lauri A. 
Published: March 2013

Key Points
A familial form of PMBCL is reported for the first time. Exome sequencing identifies MLL 5533C>A (His1845Asn) variant segregating with lymphoma in the reported family.
Hematopoietic progenitor kinase 1 (HPK1) is required for LFA-1–mediated neutrophil recruitment during the acute inflammatory response
Authors: Jakob Sascha M. , Pick Robert , Brechtefeld Doris , Nussbaum Claudia , Kiefer Friedemann , Sperandio Markus , Walzog Barbara 
Published: March 2013

Key Points
Hematopoietic progenitor kinase 1 (HPK1) regulates LFA-1 affinity and thereby controls adhesion and postadhesion functions of neutrophils. Hematopoietic progenitor kinase 1 (HPK1) is critically involved in neutrophil trafficking during acute inflammation.
Analysis of FOXO1 mutations in diffuse large B-cell lymphoma
Authors: Trinh Diane L. , Scott David W. , Morin Ryan D. , Mendez-Lago Maria , An Jianghong , Jones Steven J. M. , Mungall Andrew J. , Zhao Yongjun , Schein Jacqueline , Steidl Christian , Connors Joseph M. , Gascoyne Randy D. , Marra Marco A. 
Published: March 2013

Key Points
Recurrent mutations in FOXO1 affect the DNA binding domain and the T24 phosphorylation site, which disrupt interactions with 14-3-3. Presence of FOXO1 mutations is associated with decreased OS, particularly in DLBCL patients of the low-risk R-IPI categories.
Apoptosis inhibitor of macrophage (AIM) expression in alveolar macrophages in COPD
Authors: Kojima Jun , Araya Jun , Hara Hiromichi , Ito Saburo , Takasaka Naoki , Kobayashi Kenji , Fujii Satoko , Tsurushige Chikako , Numata Takanori , Ishikawa Takeo , Shimizu Kenichiro , Kawaishi Makoto , Saito Keisuke , Kamiya Noriki , Hirano Jun , Odaka Makoto , Morikawa Toshiaki , Hano Hiroshi , Arai Satoko , Miyazaki Toru , Kaneko Yumi , Nakayama Katsutoshi , Kuwano Kazuyoshi 
Published: March 2013

Abstract

Background
Marked accumulation of alveolar macrophages (AM) conferred by apoptosis resistance has been implicated in pathogenesis of chronic obstructive pulmonary disease (COPD). Apoptosis inhibitor of macrophage (AIM), has been shown to be produced by mature tissue macrophages and AIM demonstrates anti-apoptotic property against multiple apoptosis-inducing stimuli. Accordingly, we attempt to determine if AIM is expressed in AM and whether AIM is involved in the regulation of apoptosis in the setting of cigarette smoke extract (CSE) exposure.

Methods
Immunohistochemical evaluations of AIM were performed. Immunostaining was assessed by counting total and positively staining AM numbers in each case (n = 5 in control, n = 5 in non-COPD smoker, n = 5 in COPD). AM were isolated from bronchoalveolar lavage fluid (BALF). The changes of AIM expression levels in response to CSE exposure in AM were evaluated. Knock-down of anti-apoptotic Bcl-xL was mediated by siRNA transfection. U937 monocyte-macrophage cell line was used to explore the anti-apoptotic properties of AIM.

Results
The numbers of AM and AIM-positive AM were significantly increased in COPD lungs. AIM expression was demonstrated at both mRNA and protein levels in isolated AM, which was enhanced in response to CSE exposure. AIM significantly increased Bcl-xL expression levels in AM and Bcl-xL was involved in a part of anti-apoptotic mechanisms of AIM in U937 cells in the setting of CSE exposure.

Conclusions
These results suggest that AIM expression in association with cigarette smoking may be involved in accumulation of AM in COPD.
Conditional expression of retrovirally delivered anti-MYCN shRNA as an in vitro model system to study neuronal differentiation in MYCN-amplified neuroblastoma
Authors: Henriksen Jørn R , Haug Bjørn Helge , Buechner Jochen , Tømte Ellen , Løkke Cecilie , Flaegstad Trond , Einvik Christer 
Published: March 2013

Abstract

Background
Neuroblastoma is a childhood cancer derived from immature cells of the sympathetic nervous system. The disease is clinically heterogeneous, ranging from neuronal differentiated benign ganglioneuromas to aggressive metastatic tumours with poor prognosis. Amplification of the MYCN oncogene is a well established poor prognostic factor found in up to 40% of high risk neuroblastomas.
Using neuroblastoma cell lines to study neuronal differentiation in vitro is now well established. Several protocols, including exposure to various agents and growth factors, will differentiate neuroblastoma cell lines into neuron-like cells. These cells are characterized by a neuronal morphology with long extensively branched neurites and expression of several neurospecific markers.

Results
In this study we use retrovirally delivered inducible short-hairpin RNA (shRNA) modules to knock down MYCN expression in MYCN-amplified (MNA) neuroblastoma cell lines. By addition of the inducer doxycycline, we show that the Kelly and SK-N-BE(2) neuroblastoma cell lines efficiently differentiate into neuron-like cells with an extensive network of neurites. These cells are further characterized by increased expression of the neuronal differentiation markers NFL and GAP43. In addition, we show that induced expression of retrovirally delivered anti-MYCN shRNA inhibits cell proliferation by increasing the fraction of MNA neuroblastoma cells in the G1 phase of the cell cycle and that the clonogenic growth potential of these cells was also dramatically reduced.

Conclusion
We have developed an efficient MYCN-knockdown in vitro model system to study neuronal differentiation in MNA neuroblastomas.
Co-synergism of endophyte Penicillium resedanum LK6 with salicylic acid helped Capsicum annuumin biomass recovery and osmotic stress mitigation
Authors: Khan Abdul Latif , Waqas Muhammad , Hamayun Muhammad , Al-Harrasi Ahmed , Al-Rawahi Ahmed , Lee In-Jung 
Published: March 2013

Abstract

Background
Water-deficiency adversely affects crop growth by generating reactive oxygen species (ROS) at cellular level. To mitigate such stressful events, it was aimed to investigate the co-synergism of exogenous salicylic acid (SA) and symbiosis of endophytic fungus with Capsicum annuum L. (pepper).

Results
The findings of the study showed that exogenous SA (10-6 M) application to endophyte (Penicillium resedanum LK6) infected plants not only increased the shoot length and chlorophyll content but also improved the biomass recovery of pepper plants under polyethylene glycol (15%) induced osmotic stress (2, 4 and 8 days). Endophyte-infected plants had low cellular injury and high photosynthesis rate. SA also enhanced the colonization rate of endophyte in the host-plant roots. Endophyte and SA, in combination, reduced the production of ROS by increasing the total polyphenol, reduce glutathione, catalase, peroxidase and polyphenol oxidase as compared to control plants. Osmotic stress pronounced the lipid peroxidation and superoxide anions formation in control plants as compared to endophyte and SA-treated plants. The endogenous SA contents were significantly higher in pepper plants treated with endophyte and SA under osmotic stress as compared to control.

Conclusion
Endophytic fungal symbiosis and exogenous SA application can help the plants to relieve the adverse effects of osmotic stress by decreasing losses in biomass as compared to non-inoculated plants. These findings suggest that SA application positively impact microbial colonization while in combination, it reprograms the plant growth under various intervals of drought stress. Such symbiotic strategy can be useful for expanding agriculture production in drought prone lands.
MLPA-based genotype–phenotype analysis in 1053 Chinese patients with DMD/BMD
Authors: Yang Juan , Li Shao Y , Li Ya Q , Cao Ji Q , Feng Shan W , Wang Yan Y , Zhan Yi X , Yu Chang S , Chen Fei , Li Jing , Sun Xiao F , Zhang Cheng 
Published: March 2013

Abstract

Background
Large-scale analysis of the transmission, mutation characteristics and the relationship between the reading frame and phenotype of the DMD gene has previously been performed in several countries, however, analogous studies have yet to be performed in Chinese populations.

Methods
Clinical data from 1053 Chinese patients with DMD/BMD were collected, and the DMD gene was tested by MLPA in all patients and 400 proband mothers. In 20 patients with negative MLPA, sequencing was also performed.

Results
We found that 27.50% of cases had a family medical history of DMD/BMD, and large rearrangements were identified in 70.56% of the probands, of which 59.35% and 11.21% were deletions or duplications, respectively. The carrier status of the mothers in the study was determined to be 50.75%, and it was established that the DMD mutation was inherited from the mother in 51.72% of the probands. Exons 45–54 and 3–22 were the most frequently deleted regions, and exons 3–11 and 21–37 were the most prevalently duplicated regions of the gene. Breakpoints mainly occurred in introns 43–55 for deletion mutations and in introns 2 and 7 for duplication mutations. No breakpoints were found at the 5′ or 3′ end of introns 31, 35, 36, 40, 65, 68, and 74–78 in any of the deletion or duplication mutations. The reading frame rule held true for 86.4% of the DMD patients and 74.55% of the BMD patients.

Conclusion
It is essential to increase physicians’ understanding of DMD/BMD, to promote scientific information, and to increase awareness in regards to genetic counseling and prenatal diagnosis in pedigrees with a family history of the disease, particularly in families with small DMD lesions in China. In addition, such a large-scale analysis will prove to be instructive for leading translational studies between basic science and clinical medicine.