bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain Phenotype in Patients With Knee Osteoarthritis: Classification and Measurement Properties of painDETECT and Self‐Report Leeds Assessment of Neuropathic Symptoms and Signs Scale in a Cross‐Sectional Study
Authors: Moreton Bryan J. , Tew Victoria , das Nair Roshan , Wheeler Maggie , Walsh David A. , Lincoln Nadina B. 
Published: August 2014

ObjectiveMultiple mechanisms are involved in pain associated with osteoarthritis (OA). The painDETECT and Self‐Report Leeds Assessment of Neuropathic Symptoms and Signs (S‐LANSS) questionnaires screen for neuropathic pain and may also identify individuals with musculoskeletal pain who exhibit abnormal central pain processing. The aim of this cross‐sectional study was to evaluate painDETECT and S‐LANSS for classification agreement and fit to the Rasch model, and to explore their relationship to pain severity and pain mechanisms in OA.MethodsA total of 192 patients with knee OA completed questionnaires covering different aspects of pain. Another group of 77 patients with knee OA completed questionnaires and underwent quantitative sensory testing for pressure–pain thresholds (PPTs). Agreement between painDETECT and S‐LANSS was evaluated using kappa coefficients and receiver operator characteristic (ROC) curves. Rasch analysis of both questionnaires was conducted. Relationships between screening questionnaires and measures of pain severity or PPTs were calculated using correlations.ResultsPainDETECT and S‐LANSS shared a stronger correlation with each other than with measures of pain severity. ROC curves identified optimal cutoff scores for painDETECT and S‐LANSS to maximize agreement, but the kappa coefficient was low (κ = 0.33–0.46). Rasch analysis supported the measurement properties of painDETECT but not those of S‐LANSS. Higher painDETECT scores were associated with widespread reductions in PPTs.ConclusionThe data suggest that painDETECT assesses pain quality associated with augmented central pain processing in patients with OA. Although developed as a screening questionnaire, painDETECT may also function as a measure of characteristics that indicate augmented central pain processing. Agreement between painDETECT and S‐LANSS for pain classification was low, and it is currently unknown which tool may best predict treatment outcome.
Indicators of Walking Speed in Rheumatoid Arthritis: Relative Influence of Articular, Psychosocial, and Body Composition Characteristics
Authors: Lusa Amanda L. , Amigues Isabelle , Kramer Henry R. , Dam Thuy‐Tien , Giles Jon T. 
Published: August 2014

ObjectiveTo explore the contributions from and interactions between articular swelling and damage, psychosocial factors, and body composition characteristics on walking speed in rheumatoid arthritis (RA).MethodsRA patients underwent the timed 400‐meter long‐corridor walk. Demographics, self‐reported levels of depressive symptoms and fatigue, RA characteristics, and body composition (using whole‐body dual X‐ray absorptiometry, and abdominal and thigh computed tomography) were assessed and their associations with walking speed explored.ResultsA total of 132 RA patients had data for the 400‐meter walk, among whom 107 (81%) completed the full 400 meters. Significant multivariable indicators of slower walking speed were older age, higher depression scores, higher reported pain and fatigue, higher swollen and replaced joint counts, higher cumulative prednisone exposure, nontreatment with disease‐modifying antirheumatic drugs, and worse body composition. These features accounted for 60% of the modeled variability in walking speed. Among specific articular features, slower walking speed was primarily correlated with large/medium lower‐extremity joint involvement. However, these articular features accounted for only 21% of the explainable variability in walking speed. Having any relevant articular characteristic was associated with a 20% lower walking speed among those with worse body composition (P < 0.001), compared with only a 6% lower speed among those with better body composition (P = 0.010 for interaction).ConclusionPsychosocial factors and body composition are potentially reversible contributors to walking speed in RA. Relative to articular disease activity and damage, nonarticular indicators were collectively more potent indicators of an individual's mobility limitations.
Major Depression Diagnoses Among Patients With Systemic Sclerosis: Baseline and One‐Month Followup
Authors: Thombs Brett D. , Jewett Lisa R. , Kwakkenbos Linda , Hudson Marie , Baron Murray ,   the Canadian Scleroderma Research Group
Published: August 2014

ObjectiveDepression is common in many rheumatic diseases and is associated with poor prognosis. No studies of patients with any rheumatic diseases, however, have assessed the stability of major depressive disorder (MDD) diagnoses over time. The objective of the present study was to assess the stability of MDD diagnoses among patients with systemic sclerosis (SSc; scleroderma), a rare autoimmune rheumatic disease, across 2 assessments approximately 1 month apart.MethodsSSc patients were recruited from 7 Canadian Scleroderma Research Group Registry sites (April 2009 to June 2012). Current (30‐day) MDD was assessed with the Composite International Diagnostic Interview at baseline and approximately 1 month later.ResultsAmong 309 patients with baseline assessments who received followup assessments an average of 34 days later, prevalence of 30‐day MDD was 4% (95% confidence interval [95% CI] 2%–7%; n = 12) at baseline and 5% (95% CI 3%–8%; n = 16) at followup. Only 3 of 12 patients (25% [95% CI 9%–53%]) with MDD at baseline had MDD 1 month later.ConclusionMost patients with SSc who meet criteria for MDD appear to experience mild, time‐limited episodes of low mood that often resolve on their own without specific treatment. Consistent with international guidelines on depression management in nonpsychiatric settings, “watchful waiting” or “active monitoring” is a good strategy for SSc patients with mild depression to avoid unnecessary treatment among those whose symptoms may be transient and may resolve without medical intervention.
Validation of the LupusPRO in Chinese Patients From Hong Kong With Systemic Lupus Erythematosus
Authors: Mok Chi Chiu , Kosinski Mark , Ho Ling Yin , Chan Kar Li , Jolly Meenakshi 
Published: August 2014

ObjectiveLupusPRO is a disease‐targeted, patient‐reported outcome (PRO) measure that was developed and validated for assessment of quality of life in US patients with systemic lupus erythematosus (SLE). We present results of adapting the LupusPRO into Chinese and testing its psychometric properties in Chinese patients with SLE.MethodsLupusPRO was translated into “traditional” Chinese, followed by pretesting among native Cantonese Chinese speakers. The translation version was revised based on the feedback obtained. The Chinese language LupusPRO tool was administered along with a generic PRO tool (the Short Form 36 health survey [SF‐36]) to ethnic Chinese SLE patients. At the same time, demographic information, clinical data, disease activity (Safety of Estrogens in Lupus Erythematosus National Assessment [SELENA] version of the Systemic Lupus Erythematosus Disease Activity Index [SLEDAI]), and damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index [SDI]) were obtained. We performed confirmatory factor analysis of the Chinese LupusPRO and evaluated internal consistency reliability, as well as convergent and criterion validity.ResultsAmong the 463 SLE patients (95% women) with a mean ± SD age of 42.3 ± 13.5 years, the mean ± SD physician global assessment score was 0.48 ± 0.45, the mean ± SD SELENA‐SLEDAI score was 2.9 ± 3.0, and the mean ± SD SDI score was 0.7 ± 1.2. Results of factor analysis conformed to the original LupusPRO model with only minor modifications. The reliability of the LupusPRO domains ranged from 0.60–0.94. LupusPRO domains had correlations as expected with the corresponding SF‐36 domains. A significant but weak correlation with disease activity was noted for criterion validity as expected.ConclusionThe Chinese language LupusPRO has fair psychometric properties and may be used in SLE clinical trials.
Rheumatoid Arthritis Referrals and Rheumatologist Scarcity: A Prioritization Tool
Authors: Cummins Lisa L. , Vangaveti Venkat , Roberts Lynden J. 
Published: August 2014

ObjectiveTo assess whether applying the 2010 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) criteria for rheumatoid arthritis (RA) to primary care referrals improved triage decisions and reduced waiting times, and to determine the sensitivity and specificity of this strategy.MethodsThe 2010 ACR/EULAR criteria for RA were prospectively applied over 8 months to all new adult rheumatology referrals with possible inflammatory arthritis. If the referral contained insufficient information, a request was sent for more information. Joint count was based on physician report, and definite swelling was not required. Referrals meeting triage criteria were offered an appointment within 6 weeks. Data were collected on rheumatologist diagnosis, disease‐modifying antirheumatic drug (DMARD) use, and waiting times.ResultsOf 457 referrals screened, 180 met inclusion and exclusion criteria, and 143 had sufficient data after requests for information. Seventy‐one referrals met triage criteria, and of the 63 attending the appointment, 25 (40%) received a rheumatologist diagnosis of RA. Seventy‐two referrals did not meet criteria, and 1 of 49 attending (2%) had RA. The characteristics of the tool for a diagnosis of RA were sensitivity 96%, specificity 56%, positive predictive value 40%, and negative predictive value 98%. Median wait times for referrals fulfilling and not fulfilling triage tool criteria were 7.9 weeks and 45.4 weeks, respectively.ConclusionImplementing the 2010 ACR/EULAR criteria for RA as a prioritization tool for primary care referrals improved the number of patients subsequently diagnosed with RA. Waiting time was reduced for RA patients. Applying this strategy in areas of rheumatologist scarcity may permit earlier DMARD treatment.
Preliminary Evidence of Altered Biomechanics in Adolescents With Juvenile Fibromyalgia
Authors: Sil Soumitri , Thomas Staci , DiCesare Christopher , Strotman Daniel , Ting Tracy V. , Myer Gregory , Kashikar‐Zuck Susmita 
Published: August 2014

ObjectiveJuvenile fibromyalgia (FM) is characterized by chronic musculoskeletal pain and marked reduction in physical activity. Despite recommendations for exercise to manage juvenile FM pain, exercise adherence is poor. Because of pain and activity avoidance, adolescents with juvenile FM are at risk for altered joint mechanics that may make them susceptible to increased pain and reduced tolerance for exercise. The primary aim of this study was to assess functional deficits in patients with juvenile FM compared to healthy controls using objective biomechanical assessment.MethodsFemale adolescent patients with juvenile FM (n = 17) and healthy controls (n = 14) completed biomechanical assessments, including gait analysis and tests of lower extremity strength (isokinetic knee extension/flexion and hip abduction) and functional performance (drop vertical jump test) along with self‐reported measures of disability (Functional Disability Inventory), pain intensity, depressive symptoms (Children's Depression Inventory), and fear of movement (Tampa Scale of Kinesiophobia).ResultsPatients with juvenile FM demonstrated mild deficiencies in walking gait and functional performance (P < 0.05 for both) and significantly lower left knee extension and flexion strength (18–22% deficit) and bilateral hip abduction strength (34–38%) compared with healthy controls (P < 0.008 for all). Patients with juvenile FM reported significantly higher functional disability, pain intensity, depressive symptoms, and fear of movement relative to controls (P < 0.01 for all).ConclusionThis study showed that adolescents with juvenile FM exhibited objective alterations in biomechanics and self‐reported fear of movement that may have reinforced their activity avoidance. Interventions for juvenile FM should include a focus on correcting functional deficits and instilling greater confidence in adolescents with juvenile FM to engage in exercise to improve functional outcomes.
Asymmetric Alkynylative Ring Opening Reaction of Oxabenzonorbornadienes Promoted by Palladium/Silver Cocatalytic System
Authors: Liu Shanshan , Li Sifeng , Chen Hualei , Yang Qingjing , Xu Jianbin , Zhou Yongyun , Yuan Minglong , Zeng Weimin , Fan Baomin 
Published: August 2014

AbstractThe combination of palladium(II) acetate/(R)‐xylyl‐Phanephos and silver triflate (Pd:Ag=1:1) was found to be an efficient catalytic system for the asymmetric ring opening reactions of oxabenzonorbornadienes with terminal alkynes. The products were typically afforded in good yields (up to 95% yield) and with high enantioselectivities (up to 99% ee).magnified image
ansa‐Ruthenium(II) Complexes of DPEN‐SO2N(Me)(CH2)n(η6‐aryl) Conjugate Ligands for Asymmetric Transfer Hydrogenation of Aryl Ketones
Authors: Kišić Andrea , Stephan Michel , Mohar Barbara 
Published: August 2014

AbstractA diversified ansa‐ruthenium(II) catalyst series 1b–f displaying enantiopure N,C‐(N‐alkylene‐N‐methylsulfamoyl)‐tethered (DPEN‐κ2N,N′)/η6‐arene (DPEN=trans‐1,2‐diphenylethylenediamine) hybrid ligands was screened in the transfer hydrogenation of alkyl aryl ketones, and α‐ or β‐diketones in formic acid‐triethylamine (HCO2H‐Et3N) medium under mild conditions and furnished the alcohols in high to excellent ees.magnified image
Chemical Copolymerization and Characterization of Colloidal Poly(aniline‐co‐3‐aminobenzoic acid) as a High‐Performance Antibacterial Polymer
Authors: Lashkenari Mohammad Soleimani , Eisazadeh Hossein 
Published: August 2014

ABSTRACTPolyaniline (PAn) and copolymer of aniline with 3‐amino benzoic acid was synthesized by dispersion polymerization in the presence of ammonium peroxydisulfate as an oxidant and hydroxypropylcellulose as a stabilizer. The product polymers were characterized by a number of techniques including UV–vis, Fourier transform infrared spectroscopy, scanning electron microscope, transmission electron microscopy, and thermal gravimetric analysis. The prepared polymer was then tested for the antibacterial properties against Gram‐negative bacteria; (E. coli (PTCC 1398) and P. aeruginosa (PTCC 1310)) and Gram‐positive bacteria (S. aureus (ATCC 25923)). The antibacterial properties were assessed by the disk diffusion method, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). The results clearly showed that colloidal PAn strongly inhibits the growth of wild‐type E. coli (19 ± 0.5 mm) followed by P. aeruginosa (17 ± 0.5 mm) and S. aureus (17 ± 0.5 mm) bacteria. Poly(aniline‐co‐3‐aminobenzoic acid) (PAn3ABA) in comparison with the pristine PAn showed moderate antibacterial activity against E. coli (11 ± 0.5 mm) followed by P. aeruginosa (10 ± 0.5 mm) and S. aureus (7 ± 0.5 mm). It was found that the MIC values of colloidal PAn and PAn3ABA against E. coli were 0.62 and 1.25 mg/mL, respectively. In addition, the MBC value of colloidal PAn and PAn3ABA against E. coli was of same value (1.25 mg/mL).
Mood, behavior, testosterone, cortisol, and interleukin‐6 in adults during immune activation: A pilot study to assess sickness behaviors in humans
Authors: Shattuck Eric C. , Muehlenbein Michael P. 
Published: August 2014

ObjectivesSickness behavior, a suite of behavioral changes subsequent to infection that includes depression, decreased social behaviors, and sleep disturbances, has been well described in model organisms. The phenomenon is relatively unexplored in humans due to methodological difficulties, and hormonal correlates of sickness behavior have not been studied. We therefore attempted to use a vaccine to elicit sickness behaviors outside of a clinical setting and uncover any correlations among testosterone, cortisol, and sickness behavior.MethodsEleven participants (five male, six female, mean age 22.8 years) naïve to the rabies vaccine were recruited from the School of Veterinary Medicine at Purdue University. Participants provided daily saliva and urine samples and completed questionnaires to assess mood and social behaviors for a period of 6 weeks. Saliva samples were assayed for cortisol and testosterone. Urine samples were assayed for interleukin‐6 and creatinine.ResultsAnalysis revealed an expected decrease in testosterone and an increase in cortisol. While mood did not differ, other behaviors, such as physical activity and hours slept, showed expected changes following vaccination. However, none of these results achieved statistical significance.ConclusionOur results, while generally confirming previous research on sickness behavior and hormone changes during infection, are suggestive, but not statistically significant and so neither confirm nor contradict our hypotheses. We attribute this lack of significance to both the small sample size, as well as possible confounding factors, including the psychosocial stress of entering an intensive study program. Am. J. Hum. Biol. 27:133–135, 2015. © 2014 Wiley Periodicals, Inc.
A comparison of the long‐term results of crushing and crushing with intrinsic stripping techniques in concha bullosa surgery
Authors: Eren Sabri Baki , Kocak Ilker , Dogan Remzi , Ozturan Orhan , Yildirim Yavuz Selim , Tugrul Selahattin 
Published: August 2014

BackgroundA prospective endoscopic and radiologic evaluation of long‐term outcomes of crushing and crushing with intrinsic stripping, 2 minimally destructive techniques used for the surgical treatment of concha bullosa.MethodsForty‐two patients who underwent concha bullosa surgery (a total of 55 conchae surgeries) were included in the study. The patients were allocated consecutively to either of the 2 groups: Group 1 (crushing, n = 28) and Group 2 (crushing with intrinsic stripping, n = 27). All procedures were performed endoscopically. The presurgical and 1‐year postsurgical endoscopic nasal cavity images and computed tomography (CT) scans of all patients were recorded. Preoperative and postoperative measurements were compared using paired t test and Student t test.ResultsGender and mean age of the 42 patients (55 conchae bullosa) were as follows: 23 males, mean age 25.6 (range, 18 to 41) years; 18 females, mean age 24.2 (range, 18 to 33) years. The patients were followed for 12.5 ± 1.3 months. Comparisons of both the grading of endoscopic images and the concha bullosa volumes measured in CT images before and after treatment showed significant postsurgical reductions in both groups; comparison between groups showed significant postsurgical decreases for Group 2 in both concha bullosa volumes and in endoscopic scoring (p < 0.05).ConclusionCrushing with intrinsic stripping is an effective and easy technique; when compared to crushing alone; this technique provides a significantly more decrease in middle concha volumes as demonstrated both by the CT and by endoscopic evaluations.
P‐glycoprotein inhibition promotes prednisone retention in human sinonasal polyp explants
Authors: Kocharyan Armine , Feldman Rachel , Singleton Amy , Han Xue , Bleier Benjamin S. 
Published: August 2014

BackgroundP‐glycoprotein (P‐gp) is an efflux pump, which is part of the innate chemo‐immunity defense system and is overexpressed in chronic rhinosinusitis with nasal polyps (CRSwNP). P‐gp is capable of regulating corticosteroid retention and thus P‐gp upregulation has been implicated in steroid resistance in several inflammatory disorders. The goal of this study is to determine whether P‐gp regulates intracellular steroid retention in CRSwNP.MethodsThis was a Massachusetts Eye and Ear Infirmary Institutional Review Board (IRB)‐approved study in nasal polyp explants. Polyps were exposed to 50 μg/mL of prednisone for 30 minutes with or without the presence of a P‐gp inhibitor (Verapamil 12.5 μM or Zosuquidar 0.31 μM) followed by a 40‐minute washout period (n = 16 per group). Intracellular steroid retention was determined by quantifying the concentration of both intracytoplasmic and secreted steroid using an enzyme‐linked immunosorbent assay (ELISA). Concentrations relative to control were compared using a Student t test.ResultsThe intracytoplasmic prednisone concentration was significantly greater relative to control following P‐gp inhibition with Verapamil (155.28% ± 22.48%, p < 0.05) and Zosuquidar (125.81% ± 12.41%, p < 0.05). Similarly, the amount of prednisone secreted by the explant was significantly reduced at 30 minutes following P‐gp inhibition with Zosuquidar (78.64% ± 2.98%, p < 0.05) and 40 minutes following P‐gp inhibition with Verapamil (80.56% ± 5.02%, p < 0.05).ConclusionInhibition of P‐gp enhances the intracellular accumulation of prednisone in nasal polyps. This suggests that P‐gp participates in regulation of glucocorticoid retention in sinonasal mucosa. These findings, coupled with the known overexpression of P‐gp in CRSwNP, may point to a possible mechanism for steroid resistance in this patient population.
Dying neurons in thalamus of asphyxiated term newborns and rats are autophagic
Authors: Ginet Vanessa , Pittet Marie P. , Rummel Coralie , Osterheld Maria Chiara , Meuli Reto , Clarke Peter G. H. , Puyal Julien , Truttmann Anita C. 
Published: August 2014

ObjectiveNeonatal hypoxic–ischemic encephalopathy (HIE) still carries a high burden by its mortality and long‐term neurological morbidity in survivors. Apart from hypothermia, there is no acknowledged therapy for HIE, reflecting the lack of mechanistic understanding of its pathophysiology. (Macro)autophagy, a physiological intracellular process of lysosomal degradation, has been proposed to be excessively activated in excitotoxic conditions such as HIE. The present study examines whether neuronal autophagy in the thalamus of asphyxiated human newborns or P7 rats is enhanced and related to neuronal death processes.MethodsNeuronal autophagy and cell death were evaluated in the thalamus (frequently injured in severe HIE) of both human newborns who died after severe HIE (n = 5) and P7 hypoxic–ischemic rats (Rice–Vannuci model). Autophagic (LC3, p62), lysosomal (LAMP1, cathepsins), and cell death (TUNEL, caspase‐3) markers were studied by immunohistochemistry in human and rat brain sections, and by additional methods in rats (immunoblotting, histochemistry, and electron microscopy).ResultsFollowing severe perinatal asphyxia in both humans and rats, thalamic neurons displayed up to 10‐fold (p < 0.001) higher numbers of autophagosomes and lysosomes, implying an enhanced autophagic flux. The highly autophagic neurons presented strong features of apoptosis. These findings were confirmed and elucidated in more detail in rats.InterpretationThese results show for the first time that autophagy is enhanced in severe HIE in dying thalamic neurons of human newborns, as in rats. Experimental neuroprotective strategies targeting autophagy could thus be a promising lead to follow for the development of future therapeutic approaches. Ann Neurol 2014;76:695–711
Enantioselektive allylische Hydroxylierung von ω‐Alkensäuren und ‐estern mittels der P450‐BM3‐Monooxygenase
Authors: Neufeld Katharina , Henßen Birgit , Pietruszka Jörg 
Published: August 2014

AbstractChirale Allylalkohole der ω‐Alkensäuren und entsprechende Derivate sind essentielle Bausteine für die Synthese biologisch aktiver Verbindungen. Die direkte enantioselektive C‐H‐Oxidation von linearen terminalen Olefinen ermöglicht den effizientesten Zugang zu diesen Strukturen. Synthetische Methoden für diese Umsetzungen stehen jedoch nur begrenzt zur Verfügung und liefern unzureichende Selektivitäten. Hier wird ein enzymatischer Ansatz zu diesen interessanten Zielverbindungen mittels der P450‐BM3‐Monooxygenase vorgestellt, der allylische Hydroxylierungen mit hohen bis exzellenten Chemo‐ und Enantioselektivitäten ermöglicht.