bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence, incidence, and mortality of Raynaud’s phenomenon, Sjögren’s syndrome and scleroderma: an umbrella review of systematic reviews
Authors: Chen Anthony , Lax Stephanie J , Grainge Matthew J , Lanyon Peter C , Pearce Fiona A 
Published: July 2024

Abstract

Objectives
To comprehensively review systematic reviews of prevalence, incidence, and mortality of Raynaud’s, Sjögren’s and Scleroderma, and to identify any research gaps.

Methods
An umbrella review of English language systematic reviews was undertaken using PubMed and Embase (OVID) covering the period 2000–2023 (PROSPERO CRD42023434865). The estimate and its corresponding 95% confidence interval were reported when available from each systematic review. The quality of systematic reviews was assessed using the Scottish Intercollegiate Guidelines Network (SIGN) tool. A narrative synthesis was undertaken.

Results
Seventeen systematic reviews were identified, of which 1 was for RP, 5 for Sjögren’s and 11 for Scleroderma. There were some high-quality systematic reviews for Sjögren’s and mortality of Scleroderma. However, there were only low-quality systematic reviews of prevalence and incidence of RP and Scleroderma. Furthermore, there were no systematic reviews for the mortality of RP. For RP, the pooled prevalence was 4850 per 100 000; pooled annual incidence was 250 per 100 000. For Sjögren’s, prevalence was 60–70 per 100 000; annual incidence was 6.92 per 100 000 and the pooled standardized mortality ratio ranged from 1.38 to 1.48. For Scleroderma, pooled prevalence ranged from 17.6 to 23 per 100 000; annual incidence was 1.4 per 100 000; and the pooled standardized mortality ratio ranged from 2.72 to 3.53.

Conclusion
The outcomes of RP were less well described compared with Sjögren’s and Scleroderma. There was a lack of high-quality systematic reviews for the prevalence and incidence of RP and Scleroderma. Therefore, further studies and systematic reviews with rigorous case definitions, assessing different ethnic groups are warranted in this area.
Elicitation of expert prior opinion to design the BARJDM trial in juvenile dermatomyositis
Authors: Papadopoulou Charalampia , Martin Neil , Rafiq Nadia , McCann Liza , Varner Giulia , Nott Kerstin , Compeyrot-Lacassagne Sandrine , Leandro Maria , Foley Charlene , Warrier Kishore , Green Nathan , Wan Mandy , Dehbi Hakim-Moulay , Whitehead John , Eleftheriou Despina , Brogan Paul 
Published: July 2024

Abstract

Objectives
To elicit and quantify expert opinion concerning the relative merits of two treatments for a rare inflammatory disease: JDM. The formal expression of expert opinion reported in this article will be used in a Bayesian analysis of a forthcoming randomized controlled trial known as BARJDM (baricitinib for JDM).

Methods
A Bayesian prior elicitation meeting was convened, following a previously described methodological template. Opinion was sought on the probability that a patient in the BARJDM trial would achieve clinically inactive disease, off glucocorticoids (GC) within a 12-month period with either MTX (standard of care); or baricitinib (a Janus kinase inhibitor, JAKi), with GC schedules identical in both arms of the trial. Experts’ views were discussed and refined following presentation and further discussion of summated published data regarding efficacy of MTX or JAKi for JDM.

Results
Ten UK paediatric rheumatology consultants (including one adolescent paediatric rheumatologist) participated in the elicitation meeting. All had expertise in JDM, leading active National Health Service clinics for this disease. Consensus expert prior opinion was that the most likely probability of clinically inactive disease off GC within 12 months was 0.55 on baricitinib and 0.23 on MTX, with a greater degree of uncertainty for baricitinib.

Conclusion
Experts currently think that baricitinib is superior to MTX for the treatment of JDM, although there is uncertainty around this. BARJDM will therefore integrate randomized trial data with this expert prior opinion to derive a posterior distribution for the relative efficacy of baricitinib compared with MTX.
Association between bladder cancer treatment and female sexual function
Authors: Li Yakui , Zheng Ming , Na Lei , Wang Mingli 
Published: July 2024

Abstract

Introduction
Bladder cancer ranks 17th in prevalence of cancer types among women, and the trend is rising. The increased risk of female sexual dysfunction (FSD) after radical cystectomy (RC) underscores the need for greater focus on preserving and mitigating FSD.

Objectives
To place greater emphasis on the importance of female sexual function (FSF) in the treatment of bladder cancer and stimulate additional research to discover more effective solutions for enhancing the overall quality of life.

Methods
This review used a narrative approach. Previous reviews on FSF after RC have provided limited and 1-sided solutions due to the lack of research. What makes this review unique is its innovative approach: it includes all available measures curing FSD as well as comparative analyses based on experimental data, thus making the findings more comprehensive. A detailed perspective of treatments for female bladder cancer is provided, including nerve- and organ-sparing RC, robot-assisted RC, and radiotherapy. We also analyze the impact of treatments for female bladder cancer on postoperative FSD. Additionally, solutions for addressing or alleviating postoperative FSD are summarized, such as urinary diversion, vaginal reconstruction, and drug and nondrug treatment.

Results
Research has suggested that robot-assisted nerve- and organ-sparing RC is promising. Moreover, orthotopic neobladder among urinary diversions without a stoma helps to maintain a positive female body image. If part of the anterior vaginal wall must be removed during RC, vaginal reconstruction can restore the dimensions with synthetic grafts and biologic scaffolds. Additionally, postoperative measures, such as vaginal laser and hormone therapy, and use of vaginal dilators and lubricants have a significant role in reducing distress caused by FSD to provide maximum relief.

Conclusions
To support FSF after RC, various interventions are needed, and urologists must focus on patient recovery while minimizing treatment impact on FSF as much as possible.
Blood Distribution of SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine in Humans
Authors: Kent Stephen J. , Li Shiyao , Amarasena Thakshila H. , Reynaldi Arnold , Lee Wen Shi , Leeming Michael G. , O’Connor David H. , Nguyen Julie , Kent Helen E. , Caruso Frank , Juno Jennifer A. , Wheatley Adam K. , Davenport Miles P. , Ju Yi 
Published: July 2024

ABSTRACTLipid nanoparticle mRNA vaccines are an exciting but new technology used in humans. There is limited understanding of factors that influence their biodistribution and immunogenicity. Antibodies to polyethylene glycol (PEG), which is on the surface of the lipid nanoparticle, are detectable in humans and boosted by human mRNA vaccination. We hypothesized that PEG-specific antibodies could increase the clearance of mRNA vaccines. We developed methods to quantify both the mRNA and ionizable lipid in frequent serial blood samples from 19 subjects receiving Moderna SPIKEVAX mRNA booster immunization. Both the mRNA and ionizable lipid peaked in blood 1-2 days post vaccination (median peak level 0.19 and 3.22 ng mL-1, respectively). The mRNA was detectable out to 14-28 days post-vaccination in most subjects. We measured the proportion of mRNA that was relatively intact in blood over time and found the decay kinetics of the intact mRNA and ionizable lipid were identical, suggesting the intact lipid nanoparticle recirculates in blood. However, mRNA and ionizable lipid decay rates did not correlate with baseline levels of PEG-specific nor spike-specific antibodies. The magnitude of mRNA and ionizable lipid detected in blood did correlate with the boost in PEG antibodies. Further, the ability of subject’s monocytes to phagocytose lipid nanoparticles had an inverse relationship with the rise in PEG antibodies. This suggests circulation of mRNA lipid nanoparticle vaccines into the blood and their ability to be cleared by phagocytes influence PEG immunogenicity of mRNA vaccines. Overall, this work defines the pharmacokinetics of lipid nanoparticle mRNA vaccine components in human blood after intramuscular injection and the factors that influence this. These insights should prove useful in improving the future safety and efficacy of lipid nanoparticle mRNA vaccines and therapeutics.
Development and Validation of a Pictorial Cue Database for Cannabis Cue Reactivity Studies: Insights from Behavioral and Neural Investigations
Authors: Hamidein Zahra , Mohammad Neda , Rafei Parnian , Ebrahimi Mohsen , Ekhtiari Hamed , Ghobadi-Azbari Peyman , Rezapour Tara 
Published: July 2024

AbstractIntroductionCraving, a potent driving force behind drug-seeking and consumption behaviors, represents a dynamic emotional-motivational response primarily elicited by drug-related cues. In laboratory settings, the drug cue reactivity (DCR) paradigm is frequently employed to evoke craving and investigate the neural and behavioral responses to drug cues. This study adopts functional magnetic resonance imaging (fMRI) alongside behavioral assessments to establish a collection of validated pictorial cues encompassing both cannabis and neutral images.Methods110 cannabis-related images were selected across cannabis flowers and powder, cannabis use methods, and paraphernalia categories. Participants with a history of cannabis use were then asked to assess the selected images for craving, valence, and arousal using both the visual analog scale and the self-assessment Manikin. Using fMRI, the neural mechanisms underlying cannabis cue-reactivity were investigated at the whole-brain level and within Brainnetome atlas areas in a subgroup of 31 cannabis users.ResultsThe selected cannabis-related images (n = 110) received significantly higher craving (t = 6.56; p<0.001) and arousal (t = 17.46; p<0.001) ratings compared to the neutral ones (n = 30). Fifty regular cannabis users (19.9 ± 4.8 years; 10 females and 40 males) with at least a one-year history of use were included. Investigating blood oxygenation level-dependent (BOLD) responses to cannabis compared with neutral cues yielded significant activations in the inferior/medial frontal gyrus, fusiform gyrus, parahippocampal gyrus, orbital gyrus, postcentral gyrus, insula, precuneus, superior/middle temporal gyrus, and cerebellar tonsil.ConclusionThis study provides a resource of ecologically validated cannabis-related images useful for studies applying DCR as interventions or assessments for cannabis users.
Myocardial infarction injury is exacerbated by nicotine in vape aerosol exposure
Authors: Savko Clarissa , Esquer Carolina , Molinaro Claudia , Rokaw Sophie , Shain Abraham Grant , Jaafar Faid , Wright Morgan K. , Phillips Joy A. , Hopkins Tyler , Mikhail Sama , Rieder Abigail , Mardani Ariana , Bailey Barbara , Sussman Mark A. 
Published: July 2024

AbstractRationaleVaping is touted as a safer alternative to traditional cigarette smoking but the full spectrum of harm reduction versus comparable risk remains unresolved. Elevated bioavailability of nicotine in vape aerosol together with known risks of nicotine exposure may result in previously uncharacterized cardiovascular consequences of vaping.ObjectiveAssess the impact of nicotine exposure via vape aerosol inhalation upon myocardial response to infarction injury.Methods and ResultsFlavored vape juice containing nicotine (5 mg / ml) or vehicle alone (0 mg) was delivered using identical 4-week treatment protocols. Mice were subjected to acute myocardial infarction injury and evaluated for outcomes of cardiac structure and function. Findings reveal that nicotine exposure leads to worse outcomes with respect to contractile performance regardless of sex. Non-myocyte interstitial cell accumulation following infarction significantly increased with exposure to vape aerosol alone, but a comparable increase was not present when nicotine was included.ConclusionsMyocardial function after infarction is significantly decreased after exposure to nicotine vape aerosol irrespective of sex. Comparable loss of contractile function was not observed in mice exposed to vape aerosol alone, highlighting the essential role of nicotine in loss of contractile function. Increased vimentin immunoreactivity was observed in the vape alone group compared to control and vape nicotine. The correlation between vaping, interstitial cell responses, and cardiac remodeling leading to impaired contractility warrants further investigation. Public health experts seeking to reduce vaping-related health risks should consider messaging that highlights the increased cardiovascular risk especially with nicotine-containing aerosols.
Mapping the global knowledge landscape of digital transformation in the AEC industry: a scientometric analysis
Authors: Wang Kaiyang 
Published: July 2024

PurposeIn recent decades, interest in digital transformation (DX) within the architecture, engineering, and construction (AEC) industry has significantly increased. Despite the existence of several literature reviews on DX research, there remains a notable lack of systematic quantitative and visual investigations into the structure and evolution of this field. This study aims to address this gap by uncovering the current state, key topics, keywords, and emerging areas in DX research specific to the AEC sector.Design/methodology/approachEmploying a holistic review approach, this study undertook a thorough and systematic analysis of the literature concerning DX in the AEC industry. Utilizing a bibliometric analysis, 3,656 papers were retrieved from the Web of Science spanning the years 1990–2023. A scientometric analysis was then applied to these publications to discern patterns in publication years, geographical distribution, journals, authors, citations, and keywords.FindingsThe findings identify China, the USA, and England as the leading contributors in the field of DX in AEC sector. Prominent keywords include “building information modeling”, “design”, “system”, “framework”, “adoption”, “model”, “safety”, “internet of things”, and “innovation”. Emerging areas of interest are “deep learning”, “embodied energy”, and “machine learning”. A cluster analysis of keywords reveals key research themes such as “deep learning”, “smart buildings”, “virtual reality”, “augmented reality”, “smart contracts”, “sustainable development”, “building information modeling”, “big data”, and “3D printing”.Originality/valueThis study is among the earliest to provide a comprehensive scientometric mapping of the DX field. The findings presented here have significant implications for both industry practitioners and the scientific community, offering a thorough overview of the current state, prominent keywords, topics, and emerging areas within DX in the AEC industry. Additionally, this research serves as an invaluable reference and guideline for scholars interested in this subject.
Global trends and status of drone journalism: a systematic analysis of research constituents and key themes
Authors: Pathak Kinshuk 
Published: July 2024

Purpose
This paper aims to explore the global trends and status of drone journalism through a systematic bibliometric analysis, aiming to provide a comprehensive understanding of the field's evolution, impact and interdisciplinary nature.

Design/methodology/approach
This study uses established bibliometric tools and frameworks to systematically review scholarly publications related to drone journalism. Using the Dimensions.ai database, a systematic mapping of the intellectual landscape of drone journalism research is conducted. Bibliometrix package of R Studio was used in the study.

Findings
The analysis reveals a progressive growth in drone journalism research over the years. Although research output consistently increases, variations in impact, measured by citations and online engagement, are observed. Missing data and contextual factors necessitate careful interpretation, but trends suggest an evolving field with diverse interests and future exploration opportunities. Drone journalism research exhibits interdisciplinary characteristics, with impact varying across different research categories. The distribution of research across various publication types underscores the diversity of scholarly communication channels in the field.

Research limitations/implications
This study acknowledges limitations in its data set, stemming from specific keyword criteria, potentially limiting the comprehensive capture of all drone journalism research.

Practical implications
This study offers valuable insights for researchers, practitioners and policymakers seeking to navigate the dynamic landscape of drone journalism. The understanding of publication patterns, influential authors and interdisciplinary intersections facilitates informed decisions regarding research dissemination and impact maximization.

Originality/value
This research contributes to the evolving field of drone journalism by providing a holistic view of its trends and status. The identification of prolific authors, influential publications and evolving research themes offers valuable context for understanding the multifaceted nature of drone journalism research.
Halal tourism on an island destination: Muslim travellers’ experiences in the local islands of the Maldives
Authors: Adham Khairul Akmaliah , Mahmad Nasir Nadiah , Sinaau Aishath , Shaznie Aminath , Munawar Ahmed 
Published: July 2024

Purpose
This study extends the current understanding of halal tourism at an island destination. Specifically, this study aims to explore the attributes of halal tourism in the local islands of the Maldives, a fully Muslim country where tourism is the primary source of income for residents. To accomplish this, Muslim travellers’ experiences were examined using the process theory of travel, the halal tourism concept and the service marketing perspective.

Design/methodology/approach
The study used a qualitative research methodology and conducted interviews with Muslim travellers visiting the local islands of the Maldives.

Findings
The findings affirmed the five established generic attributes of halal tourism and generated another three emergent attributes of halal tourism, specific to an island destination. The study further enhances the existing knowledge of the generic attributes of halal food and beverage, prayers and mutual respect and benefits. It also establishes that the dimensions of safety and privacy, value for money, perishability and heterogeneity characterise all the emerging halal tourism attributes. The study concludes that halal tourism is an experience imbued with values that promotes dignified tourism.

Originality/value
The findings on the specific attributes of halal tourism at an island destination extend overall understanding of the halal tourism concept and process. The fact that the Maldives is entirely Muslim offers a unique opportunity to explore the normative attributes of halal tourism in an island destination. This enhanced understanding contributes to effective managerial practices aimed at developing competitive halal tourism services.
Evaluating the impact of adult education programs in Morocco: a quasi-experimental approach
Authors: Boukbech Rachid , Liouaeddine Mariem 
Published: July 2024

Purpose
This paper aims to evaluate the impact of the “Postliteracy” program on the qualification of beneficiaries for socioeconomic integration. This qualification is achieved first through the consolidation of the achievements of individuals freed from illiteracy, and then through their support in creating income-generating activities by providing them with technical, economic, legal and institutional knowledge to ensure their conscious and responsible participation in local and regional development efforts.

Design/methodology/approach
To evaluate the impact of the “Postliteracy” program, this paper uses quasi-experimental methods with a control group (participants of the “Literacy” program 2020 / 2021) and a treatment group (participants of the “Postliteracy” program 2021 / 2022). Skill acquisition is measured through pretest and posttest evaluations using a questionnaire aligned with the National Agency for the Fight Against Illiteracy (ANLCA)-adopted curriculum. The survey occurred at the beginning and at the end of the program, providing sufficient time for skill development. The questionnaire includes three sections covering socioprofessional characteristics, technical and economic domains and legal and institutional aspects. These sections contribute to a score reflecting the acquired skills for successful socioeconomic integration.

Findings
The results of the study demonstrate that the “Postliteracy” program has a positive impact on the acquisition of competences necessary for improved socioeconomic integration of the beneficiaries. The various matching techniques reveal a score difference ranging from 12 to 14 points in favor of program participants compared to those who did not participate. The Difference-in-Differences method confirms the positive and significant impact of the program.

Practical implications
The findings highlight the importance of the “Postliteracy” program in national literacy policy, underlining the need to further strengthen its presence within the programs deployed by ANLCA, notably by increasing the number of beneficiaries targeted by this program. To achieve this, it would be advisable to increase the funds allocated to it within ANLCA's budget.

Originality/value
The originality of this work is a unique research of the case of Morocco based on a microeconometric study for which the authors evaluate the impact of adult education by applying impact evaluation methods in the field of adult literacy.
Safety of the express freight train running over a long-span bridge
Authors: Wen Jingcheng , Qin Yihao , Bai Ye , Dong Xiaoqing 
Published: July 2024

PurposeExpress freight transportation is in rapid development currently. Owing to the higher speed of express freight train, the deformation of the bridge deck worsens the railway line condition under the action of wind and train moving load when the train runs over a long-span bridge. Besides, the blunt car body of vehicle has poor aerodynamic characteristics, bringing a greater challenge on the running stability in the crosswind.Design/methodology/approachIn this study, the aerodynamic force coefficients of express freight vehicles on the bridge are measured by scale model wind tunnel test. The dynamic model of the train-long-span steel truss bridge coupling system is established, and the dynamic response as well as the running safety of vehicle are evaluated.FindingsThe results show that wind speed has a significant influence on running safety, which is mainly reflected in the over-limitation of wheel unloading rate. The wind speed limit decreases with train speed, and it reduces to 18.83 m/s when the train speed is 160 km/h.Originality/valueThis study deepens the theoretical understanding of the interaction between vehicles and bridges and proposes new methods for analyzing similar engineering problems. It also provides a new theoretical basis for the safety assessment of express freight trains.