bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital Transformation in Thoracic Surgery: a survey among the European Society of Thoracic Surgeons
Authors: Mayer Nora , Sotiropoulos George , Novoa Nuria , Daddi Niccolo , Batirel Hasan , Asadi Nizar 
Published: June 2024

Abstract

OBJECTIVES
Digital transformation has drastically changed the surgical sector, but few is known about its impact on thoracic surgical practice. The aim of this paper is to report the European Society of Thoracic Surgeons (ESTS) survey results, assessing the impact of and the need for Digital Transformation in Thoracic Surgery.

METHODS
A 23-item survey was designed by the ESTS Digital Transformation Working Group to assess the impact of and the need for Digital Transformation in Thoracic Surgery. All ESTS members (1668) were invited to complete the survey between 13 March and 21 May 2022 anonymously. Data analysis was descriptive calculating frequencies and percentages. Group comparison was done using chi-square test.

RESULTS
The response rate was 6.3%. Surgeons from 26 European countries participated of which more than 80% were based in academic hospitals. The impact of digital transformation was rated very important (43.8%) and fundamental (22.7%) in more than two-thirds of the cases, regardless of surgeons’ age. None of the participants felt that digital transformation was of no importance and more than 85% had implemented digital platforms in their direct patient care. Almost 90% of the surgeons, currently not using digital platforms for training and education, would consider introducing them. About 70% were at least ‘somewhat satisfied’ with their current engagement in Digital Transformation in Thoracic Surgery.

CONCLUSIONS
Digital transformation seems to play a major role across European Thoracic Surgery departments in direct patient care, professional networking and surgical training. However, overall satisfaction with the current status of Digital Transformation in Thoracic Surgery was rather reserved, implying the need to increase the implementation of digital solutions in the latter.
The Use of Breast-specific Gamma Imaging as a Low-Cost Problem-Solving Strategy for Avoiding Biopsies in Patients With Inconclusive Imaging Findings on Mammography and Ultrasonography
Authors: Ko Andrew , Vo Alexander M , Miller Nathaniel , Liang Annie , Baumbach Maia , Riley Argue Jay , Manche Nathaniel , Gonzalez Luis , Austin Nicholas , Carver Philip , Procell Joseph , Elzein Hassan , Pan Margaret , Zeidan Nadine , Kasper William , Speer Samuel , Liang Yizhi , Pettus Benjamin J 
Published: June 2024

Abstract

Objective
To evaluate the clinical performance and financial costs of breast-specific gamma imaging (BSGI) as a biopsy-reducing problem-solving strategy in patients with inconclusive diagnostic imaging findings.

Methods
A retrospective analysis of all patients for whom BSGI was utilized for inconclusive imaging findings following complete diagnostic mammographic and sonographic evaluation between January 2013 and December 2018 was performed. Positive BSGI findings were correlated and biopsied with either US or stereotactic technique with confirmation by clip location and pathology. After a negative BSGI result, patients were followed for a minimum of 24 months or considered lost to follow-up and excluded (22 patients). Results of further imaging studies, biopsies, and pathology results were analyzed. Net savings of avoided biopsies were calculated based on average Medicare charges.

Results
Four hundred and forty female patients from 30 to 95 years (mean 55 years) of age were included in our study. BSGI demonstrated a negative predictive value (NPV) of 98.4% (314/319) and a positive predictive value for biopsy of 35.5% (43/121). The overall sensitivity was 89.6% (43/48), and the specificity was 80.1% (314/392). In total, 78 false positive but only 5 false negative BSGI findings were identified. Six hundred and twenty-one inconclusive imaging findings were analyzed with BSGI and a total of 309 biopsies were avoided. Estimated net financial savings from avoided biopsies were $646 897.

Conclusion
In the management of patients with inconclusive imaging findings on mammography or ultrasonography, BSGI is a problem-solving imaging modality with high NPV that helps avoid costs of image-guided biopsies.
Efficacy of 2 botanical aphicides, chicoric and 3,5-dicaffeoylquinic acids, on aphids susceptible and resistant to synthetic insecticides
Authors: Siegwart Myriam , Gauffre Bertrand , Lecerf Elodie , Poëssel Jean-Luc 
Published: June 2024

Abstract
Dicaffeoyltartaric acid (diCT) and 3,5-dicaffeoylquinic acid (3,5-diCQ) are described for their aphicidal properties on several aphid species. Intending to valorize diCT and 3,5-diCQ as biocontrol products and because of the high adaptive capacities of aphids to xenobiotics, we sought to determine the existence of adaptation first in Myzus persicae (Sulzer) (Hemiptera: Aphididae) and then other aphids. Resistance of aphids to these biopesticides could be promoted by (i) the existence of resistance to synthetic insecticides that may confer cross-resistance and (ii) the presence of these compounds in wild plants likely which may have led to pre-existing adaptation in aphids. We assessed the resistance levels to diCT and 3,5-diCQ in 7 lab strains (including some resistant to synthetic aphicides) and 7 wild populations of M. persicae using biotests. The activities of detoxification enzymes contributing to insecticide resistance were also measured. Additionally, we followed the same method to characterize susceptibility to these caffeic derivatives in wild populations of Nasonovia ribisnigri (Mosley) (Hemiptera: Aphididae), Brevicoryne brassicae(Linnaeus) (Hemiptera: Aphididae) and, Aphis craccivora(Koch) (Hemiptera: Aphididae). Our results show variability in susceptibility to diCT between populations of M. persicae, but resistance ratios (RR) were low (RR = 3.59). We found no cross-resistance between synthetic insecticides and diCT. Carboxylesterase and glutathione-S-transferase did not seem to be involved in its detoxification. A clone of A. craccivora collected from peanut, a species rich in diCT, was not susceptible to either diCT or 3,5-diCQ, suggesting a common molecular target for these 2 molecules and the existence of a high-effect resistance mechanism. These active botanical substances remain good candidates for M. persicae biocontrol in agriculture.
Exploring xylose metabolism in non-conventional yeasts: kinetic characterization and product accumulation under different aeration conditions
Authors: Bolzico Bruna C , Racca Sofia , Khawam Jorge N , Leonardi Rodrigo J , Tomassi Ariel H , Benzzo Maria T , Comelli Raul N 
Published: June 2024

Abstract

d-Xylose is a metabolizable carbon source for several non-Saccharomyces species, but not for native strains of S. cerevisiae. For the potential application of xylose-assimilating yeasts in biotechnological processes, a deeper understanding of pentose catabolism is needed. This work aimed to investigate the traits behind xylose utilization in diverse yeast species. The performance of 9 selected xylose-metabolizing yeast strains was evaluated and compared across 3 oxygenation conditions. Oxygenation diversely impacted growth, xylose consumption, and product accumulation. Xylose utilization by ethanol-producing species such as Spathaspora passalidarum and Scheffersomyces stipitis was less affected by oxygen restriction compared with other xylitol-accumulating species such as Meyerozyma guilliermondii, Naganishia liquefaciens, and Yamadazyma sp., for which increased aeration stimulated xylose assimilation considerably. Spathaspora passalidarum exhibited superior conversion of xylose to ethanol and showed the fastest growth and xylose consumption in all 3 conditions. By performing assays under identical conditions for all selected yeasts, we minimize bias in comparisons, providing valuable insight into xylose metabolism and facilitating the development of robust bioprocesses.

One-Sentence Summary
This work aims to expand the knowledge of xylose utilization in different yeast species, with a focus on how oxygenation impacts xylose assimilation.
Too amused to stop? Self-control and the disengagement process on Netflix
Authors: Gilbert Alicia , Reinecke Leonard , Meier Adrian , Baumgartner Susanne E , Dietrich Felix 
Published: June 2024

Abstract
Consuming media entertainment often challenges recipients’ self-control. While past research related self-control almost exclusively to whether individuals engage in media use, it might be equally relevant for the disengagement from media use. Testing core assumptions of the Appraisal of Media Use, Self-Control, and Entertainment (AMUSE) model, the present study investigates the situational interplay of self-control and affective appraisals in predicting disengagement from Netflix use. Preregistered hypotheses were tested based on an event-contingent experience sampling design, in which 205 adult Netflix users in the Netherlands and Germany were tracked and surveyed for two weeks. Results demonstrate that disengagement is contingent upon enjoyment and appreciation and that enjoyment, in turn, can be “spoiled” by feeling guilty. Self-control influenced goal conflict and enjoyment throughout the reception process. We discuss opportunities for modeling disengagement from media use with situational research approaches.
Strawberry phenotypic plasticity in flowering time is driven by the interaction between genetic loci and temperature
Authors: Prohaska Alexandre , Petit Aurélie , Lesemann Silke , Rey-Serra Pol , Mazzoni Luca , Masny Agnieszka , Sánchez-Sevilla José F , Potier Aline , Gaston Amèlia , Klamkowski Krzysztof , Rothan Christophe , Mezzetti Bruno , Amaya Iraida , Olbricht Klaus , Denoyes Béatrice 
Published: June 2024

Abstract
Flowering time (FT), which determines when fruits or seeds can be harvested, is subject to phenotypic plasticity, that is, the ability of a genotype to display different phenotypes in response to environmental variation. Here, we investigated how the environment affects the genetic architecture of FT in cultivated strawberry (Fragaria × ananassa) and modifies its quantitative trait locus (QTL) effects. To this end, we used a bi-parental segregating population grown for 2 years at widely divergent latitudes (five European countries) and combined climatic variables with genomic data (Affymetrix SNP array). Examination, using different phenological models, of the response of FT to photoperiod, temperature, and global radiation indicated that temperature is the main driver of FT in strawberry. We next characterized in the segregating population the phenotypic plasticity of FT by using three statistical approaches that generated plasticity parameters including reaction norm parameters. We detected 25 FT QTLs summarized as 10 unique QTLs. Mean values and plasticity parameter QTLs were co-localized in three of them, including the major 6D_M QTL whose effect is strongly modulated by temperature. The design and validation of a genetic marker for the 6D_M QTL offers great potential for breeding programs, for example selecting early-flowering strawberry varieties well adapted to different environmental conditions.
Raffinose catabolism enhances maize waterlogging tolerance by stimulating adventitious root growth and development
Authors: Yan Dong , Gao Yu , Zhang Yumin , Li Dan , Dirk Lynnette M A , Downie A Bruce , Zhao Tianyong 
Published: June 2024

Abstract
Raffinose mitigates plant heat, drought, and cold stresses; however, whether raffinose contributes to plant waterlogging tolerance is unknown. The maize raffinose synthase mutant zmrafs-1 had seedlings that lack raffinose, generated fewer and shorter adventitious roots, and were more sensitive to waterlogging stress, while overexpression of the raffinose synthase gene, ZmRAFS, increased raffinose content, stimulated adventitious root formation, and enhanced waterlogging tolerance of maize seedlings. Transcriptome analysis of null segregant seedlings compared with zmrafs-1, particularly when waterlogged, revealed that the expression of genes related to galactose metabolism and the auxin biosynthetic pathway were up-regulated by raffinose. Additionally, indole-3-acetic acid content was significantly decreased in zmrafs-1 seedlings and increased in ZmRAFS-overexpressing seedlings. Inhibition of the hydrolysis of raffinose by 1-deoxygalactonojirimycin decreased the waterlogging tolerance of maize seedlings, the expression of genes encoding proteins related to auxin transport-related genes, and the indole-3-acetic acid level in the seedlings, indicating that the hydrolysis of raffinose is necessary for maize waterlogging tolerance. These data demonstrate that raffinose catabolism stimulates adventitious root formation via the auxin signaling pathway to enhance maize waterlogging tolerance.
A Multicenter Retrospective Study Evaluating Intravenous to Oral Antibiotic Stepdown for Uncomplicated Streptococcal Bacteremia
Authors: Lew Alison K , Salam Madison E , Gross Alan E , Wang Sheila K , McGuire Erin , Pettit Natasha N , Pisano Jennifer , Nguyen Cynthia T 
Published: June 2024

Abstract

Background
The purpose of this study was to compare the efficacy and safety of intravenous (IV) versus oral (PO) stepdown therapy for uncomplicated streptococcal bacteremia.

Methods
This multicenter, retrospective study included adult patients with uncomplicated streptococcal bacteremia between 1 July 2019 and 1 July 2022. Patients who received IV therapy for the full treatment course were compared to patients who transitioned to PO therapy after initial IV therapy. The primary outcome was clinical success, defined as absence of infection recurrence, infection-related readmission, and infection-related mortality at 90 days. Secondary outcomes included microbiological success, length of stay (LOS), and IV line–associated complications.

Results
Of 238 patients included, 47.1% received PO stepdown therapy. Clinical success occurred in 94.4% and 94.6% in the IV only and PO stepdown groups, respectively (P = .946). Patients who transitioned to PO therapy received a median duration of IV therapy of 3.9 days (interquartile range, 2.9–7.3 days). Line complications were more frequent in the IV only group, primarily driven by catheter-related infections (7.2% vs 0%, P = .002). LOS was significantly shorter in the PO stepdown group (5.5 vs 9.2 days, P &lt; .001).

Conclusions
Patients transitioned to PO antibiotics for uncomplicated streptococcal bacteremia had similar rates of clinical success compared to patients who received only IV therapy. With consideration of infectious source, severity of illness, and comorbidities, PO stepdown following initial IV antibiotics for uncomplicated streptococcal bacteremia in select patients is a reasonable approach that may result in decreased LOS and line-related complications.
The tensor as an informational resource
Authors: Christandl Matthias 
Published: June 2024

Abstract
A tensor is a multidimensional array of numbers that can be used to store data, encode a computational relation, and represent quantum entanglement. In this sense, a tensor can be viewed as valuable resource whose transformation can lead to an understanding of structure in data, computational complexity, and quantum information. In order to facilitate the understanding of this resource, we propose a family of information-theoretically constructed preorders on tensors, which can be used to compare tensors with each other and to assess the existence of transformations between them. The construction places copies of a given tensor at the edges of a hypergraph and allows transformations at the vertices. A preorder is then induced by the transformations possible in a given growing sequence of hypergraphs. The new family of preorders generalizes the asymptotic restriction preorder which Strassen defined in order to study the computational complexity of matrix multiplication. We derive general properties of the preorders and their associated asymptotic notions of tensor rank and view recent results on tensor rank nonadditivity, tensor networks, and algebraic complexity in this unifying frame. We hope that this work will provide a useful vantage point for exploring tensors in applied mathematics, physics, and computer science but also from a purely mathematical point of view.
National Institute of Mental Health Support for Cognitive Treatment Development in Schizophrenia: A Narrative Review
Authors: Heinssen Robert K , Morris Sarah E , Sherrill Joel T 
Published: June 2024

Abstract
For several decades the National Institute of Mental Health (NIMH) has supported basic and translational research into cognitive impairment in schizophrenia. This article describes the Institute’s ongoing commitment to cognitive assessment and intervention research, as reflected by three signature initiatives—Measurement and Treatment Research to Improve Cognition in Schizophrenia; Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia; and Research Domain Criteria—and related funding announcements that span basic experimental studies, efficacy and comparative effectiveness trials, and implementation research designed to promote cognitive healthcare in real-world treatment settings. We discuss how trends in science and public health policy since the early 2000s have influenced NIMH treatment development activities, resulting in greater attention to (1) inclusive teams that reflect end-user perspectives on the utility of proposed studies; (2) measurement of discrete neurocognitive processes to inform targeted interventions; (3) clinical trials that produce useful information about putative illness mechanisms, promising treatment targets, and downstream clinical effects; and (4) “productive urgency” in pursuing feasible and effective cognitive interventions for psychosis. Programs employing these principles have catalyzed cognitive measurement, drug development, and behavioral intervention approaches that aim to improve neurocognition and community functioning among persons with schizophrenia. NIMH will maintain support for innovative and impactful investigator-initiated research that advances patient-centered, clinically effective, and continuously improving cognitive health care for persons with psychotic disorders.
Bidirectional associations between the duration and timing of nocturnal sleep and daytime naps in adolescents differ from weekdays to weekends
Authors: Leong Ruth L F , Tian Liang , Yu Nicole , Teo Teck Boon , Ong Ju Lynn , Chee Michael W L 
Published: June 2024

Abstract

Study Objectives
Previous studies examining bidirectional relationships between nocturnal sleep and napping have focused on sleep duration, leaving a gap in our understanding of how sleep timing contributes. Here, we assessed the duration and timing for night sleep and daytime naps, to evaluate how the previous night’s sleep influences the next day's napping, and how napping influences same-night nocturnal sleep.

Methods
We analyzed sleep diary and actigraphy data from 153 teens (males = 43.8%, mean age = 16.6 years). Participants who never napped were excluded. Nocturnal sleep-nap relationships were investigated using logistic and linear regression models separately for weekdays and weekends.

Results
Participants napped an average of 2.3 times a week. 167 school day naps and 107 weekends were recorded. Naps were on average 82.12 ± 53.34 minutes and the average nap onset was 14:58 ± 3.78 hours. Their duration, start and end times did not significantly differ between weekdays and weekends. Nocturnal sleep duration did not predict next-day nap occurrence or duration. However, on school days, earlier wake times significantly increased the likelihood of napping that day, and advanced nap timing. On weekends, later bedtimes and wake times delayed nap timing. On school days, napping longer than one’s average shortened nocturnal sleep whereas on weekends, waking from a nap later than one’s average delayed bedtimes.

Conclusions
Early wake times increase the likelihood of napping and advance the time of a nap that day. Naps may be detrimental to the same night’s sleep only if they are long and occur late, as these can delay bedtimes and shorten nocturnal sleep duration, especially on school days.

Clinical trials
The Cognitive and Metabolic Effects of Sleep Restriction in Adolescents (NFS4), https://clinicaltrials.gov/study/NCT03333512, ID: NCT03333512. Investigating Preferred Nap Schedules for Adolescents (NFS5), https://clinicaltrials.gov/study/NCT04044885, ID: NCT04044885.
Low Risk of Cardiac Complications During Long-Term Follow-Up of Opioid Dependence
Authors: Tremonti Chris , Celemajer David S. , Marel Christina , Mills Katherine , Foo Shawn , Wilson Jack , Slade Tim , Teesson Maree , Haber Paul 
Published: June 2024

Objectives
To prospectively assess rates of QT prolongation, arrhythmia, syncope, and sudden cardiac death (SCD) in a cohort of people with heroin dependence.

Methods
To estimate rates of QT prolongation, arrhythmia, and syncope, a subcohort (n = 130) from the Australian Treatment Outcomes Study, a prospective longitudinal cohort study of 615 people with heroin dependence, underwent medical history, venepuncture, and ECG at the 18- to 20-year follow-up.
To estimate rates of SCD, probabilistic matching for the entire cohort was undertaken with the Australian Institute of Health and Welfare National Death Index. Deaths were classified into suicide, accidental overdose, trauma, unknown, and disease, which were then further subclassified by probability of SCD. SCD rate was the number of possible or probable SCDs divided by total patient years from the cohort.

Results
From the subcohort, 4 participants (3%) met the criteria for QT prolongation; 3 were prescribed methadone. Seven participants (5%) reported history of arrhythmia, including 2 transferred from methadone to buprenorphine. Thirty participants (23%) reported a previous syncopal event—14 diagnosed as nonarrhythmic syncope and 13 not investigated. In the previous 12 months, 66 participants (51%) reported heroin use; 55 participants (42%) were prescribed methadone. No participant had QTc greater than 500 milliseconds.
There were 3 possible SCDs, translating to an estimated SCD rate of 0.29 (CI: 0.05, 0.8) events per 1000 patient years. More cohort members died of overdose (n = 50), suicide (n = 11), and hepatitis C (n = 4).

Conclusions
Low rates of QT prolongation, arrhythmia, syncope, and SCD in the cohort despite high rates of heroin use and methadone treatment.