bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of pubertal timing and temperamental vulnerability in adolescents' internalizing symptoms
Authors: Crockett Lisa J. , Carlo Gustavo , Wolff Jennifer M. , Hope Meredith O. 
Published: April 2013

AbstractThis longitudinal study examined the joint role of pubertal timing and temperament variables (emotional reactivity and self-regulation) in predicting adolescents' internalizing symptoms. The multiethnic sample included 1,025 adolescent girls and boys followed from age 11 to age 15 (Mage = 11.03 years at Time 1). In structural equation models, age 11 measures of pubertal timing, emotional reactivity, and self-regulation and their interactions were used to predict adolescents' internalizing behavior concurrently and at age 15. Results indicated that, among girls, early pubertal timing, higher emotional reactivity, and lower self-regulation predicted increased internalizing behavior. In addition, self-regulation moderated the effect of pubertal timing such that effects of earlier timing on subsequent internalizing were seen primarily among girls with relatively poor self-regulation. Among boys, higher levels of emotional reactivity and lower self-regulation predicted increased internalizing, but there were no effects of pubertal timing. After controlling for Time 1 internalizing symptoms, only self-regulation predicted change in internalizing symptoms. Discussion focuses on the possible interplay of temperament and pubertal development in predicting internalizing problems during adolescence.
RUbioSeq: a suite of parallelized pipelines to automate exome variation and bisulfite-seq analyses
Authors: Rubio-Camarillo Miriam , Gómez-López Gonzalo , Fernández José M. , Valencia Alfonso , Pisano David G. 
Published: April 2013

Abstract
Motivation: RUbioSeq has been developed to facilitate the primary and secondary analysis of re-sequencing projects by providing an integrated software suite of parallelized pipelines to detect exome variants (single-nucleotide variants and copy number variations) and to perform bisulfite-seq analyses automatically. RUbioSeq’s variant analysis results have been already validated and published.
Availability: http://rubioseq.sourceforge.net/.
Contact: mrubioc@cnio.es
A Regulatory Cascade Involving Class II ETHYLENE RESPONSE FACTOR Transcriptional Repressors Operates in the Progression of Leaf Senescence
Authors: Koyama Tomotsugu , Nii Haruka , Mitsuda Nobutaka , Ohta Masaru , Kitajima Sakihito , Ohme-Takagi Masaru , Sato Fumihiko 
Published: April 2013

Abstract
Leaf senescence is the final process of leaf development that involves the mobilization of nutrients from old leaves to newly growing tissues. Despite the identification of several transcription factors involved in the regulation of this process, the mechanisms underlying the progression of leaf senescence are largely unknown. Herein, we describe the proteasome-mediated regulation of class II ETHYLENE RESPONSE FACTOR (ERF) transcriptional repressors and involvement of these factors in the progression of leaf senescence in Arabidopsis (Arabidopsis thaliana). Based on previous results showing that the tobacco (Nicotiana tabacum) ERF3 (NtERF3) specifically interacts with a ubiquitin-conjugating enzyme, we examined the stability of NtERF3 in vitro and confirmed its rapid degradation by plant protein extracts. Furthermore, NtERF3 accumulated in plants treated with a proteasome inhibitor. The Arabidopsis class II ERFs AtERF4 and AtERF8 were also regulated by the proteasome and increased with plant aging. Transgenic Arabidopsis plants with enhanced expression of NtERF3, AtERF4, or AtERF8 showed precocious leaf senescence. Our gene expression and chromatin immunoprecipitation analyses suggest that AtERF4 and AtERF8 targeted the EPITHIOSPECIFIER PROTEIN/EPITHIOSPECIFYING SENESCENCE REGULATOR gene and regulated the expression of many genes involved in the progression of leaf senescence. By contrast, an aterf4 aterf8 double mutant exhibited delayed leaf senescence. Our results provide insight into the important role of class II ERFs in the progression of leaf senescence.
Parallel numerical solution of incompressible full Navier‐Stokes in 3‐D
Authors: Üstoğlu Ünal V. 
Published: April 2013

PurposeThe purpose of this paper is to develop and test an implicit scheme, accurate to the second order, for solving full Navier‐Stokes equations for three dimensional problems, using parallel algorithm.Design/methodology/approachParallel solution to the 3‐D incompressible full Navier‐Stokes equations is presented, based on two fractional steps in time and finite element in space. The accuracy of the scheme is second order in both time and space domains. Large time‐step sizes, with Courant‐Friedrichs‐Lewy (CFL) numbers much larger than unity, are taken since the momentum equation is solved implicitly. A fourth order artificial viscosity term is added. In order to stabilize the numerical solution, fourth order artificial viscosity term is used for high Reynolds number flows. The domain decomposition technique is implemented for parallel solution to the problem with matching and non‐overlapping sub‐domains. It is aimed to study both a 3D free and mixed convection problems using the developed scheme. The segregate solution for temperature field is calibrated by a 3‐D free convection problem. Then the flow case where the forced convection is one order of magnitude higher than the free convection is studied.FindingsIt is observed that the long time solution to the flow field shows oscillatory behaviour as the Reynolds number of the flow doubled while keeping the ratio of the forced to free convection fixed. The solution using a parallel algorithm gives satisfactory results, in terms of computation time and accuracy, for the natural convection problem in cubic cavity, and, the forced cooling of a room with chilled ceiling having a parabolic geometry as presented at the end. It is observed that doubling the Reynolds number, while keeping all the parameters unchanged, varies the flow behaviour completely.Originality/valueA code previously developed and published by the author only solved momentum equation and studied the velocity field. In this study, full Navier Stokes equation is solved and the code is calibrated with a well‐known 3D free‐convection for two different Rayleigh number cases and then 3D mixed convection problem is studied for two cases. Re=2000 case results, solved both by the scheme in this study and by commercial code, presented an interesting physics of the problem. For Re=2000 case, continuous cooling of the room is not possible. Doubling the Reynolds number, raising it from 1000 to 2000, while keeping all the parameters unchanged, varies the flow behaviour completely.
Business education and spirituality – the MBA with no greed
Authors: More Elizabeth , Todarello Ekaterina 
Published: April 2013

PurposeBusiness schools increasingly have come into the spotlight following a range of corporate scandals, challenged to find a new approach to business education that goes beyond financial bottom lines, and results in the responsible corporate leadership. This article seeks to address the area of “how a Catholic university deepens and revitalises its culture and institutionalises its mission and identity in business education.” It aims to do so by focussing on the marketing for and nature of the student body in a postgraduate Master of Business Administration (Executive) (MBAE) program offered intensively by the Australian Catholic University, through an analysis of scholarship applications.Design/methodology/approachThis qualitative study used latent coding which reflected its interpretative nature and was based on the classic content analysis sensitive not only to the explicit, manifest content, but also to the implicit, not obviously present content. To arrive at a trustworthy interpretation of the latent content, the method required familiarity with the contexts of the researched. In the case of the study, the analysed applications of the scholarships were placed in the larger context of the in‐depth interviews with the prospective students. As a result, a number of themes were induced from these texts.FindingsThe findings demonstrate that candidates enter the program with a balance of self and social interest, and a different focus of self‐interest, moving beyond negative greed as excessive materialism or career pursuit for money's sake. There emerged a picture of the MBAE applicant as a caring and skilled global citizen, wishing to make a positive difference to society and characterised by a sense of humility, a heightened sense of awareness, personal transformation and a sense of interconnectedness with others.Originality/valueThis small study and approach suggests that individuals are seeking more meaning not only in their workplaces, but also from their business education. It depicts the intent of the Business Faculty staff to move beyond the cultural biases of self‐centred and unrestrained individualism in order that a sole self‐interest is transcended into benefits for the organisation and broader society, including the sustainability of the natural world.
Corporate volunteering – an analysis of volunteers' motivations and demographics
Authors: Cláudia Nave Ana , do Paço Arminda 
Published: April 2013

PurposeGiven the current importance of corporate social responsibility, this research is designed to discover the motivations that lead employees to agree to participate in the corporate volunteering activities promoted by their companies and to understand whether demographic variables such as gender and age have an influence on different types of motivations.Design/methodology/approachThis research had the collaboration of a company to develop the case study about its volunteering programme and for the collection of data through an electronic questionnaire.FindingsThe variables related with the factor values were identified as the most important motivational category for people to engage in volunteering, which shows that what these volunteers want is to contribute to the success of the event and the respective social cause. On the other hand, the motivational category related with career was considered the less important.Practical implicationsThe participation in volunteering activities enable employees to broaden their communication skills, increase their aptitude for helping others, adapting, negotiating and working as a team, while also increasing their confidence, creativity, leadership capacity, their desire for continuing improvement and their problem‐solving skills.Originality/valueA great part of existing research is focused on the motivations of “conventional” volunteers which collaborate occasionally with nonprofit organizations. Thus, the present study will expand the research in the area of corporate volunteering, contributing to a better understanding of what really motivates employees to volunteer.
Salience and corporate responsibility towards natural environment and financial performance of Indian manufacturing firms
Authors: Mishra Supriti , Suar Damodar 
Published: April 2013

PurposeThis study aims to examine whether salience towards natural environment influences the corporate responsibility towards natural environment. It further aims to test whether the corporate responsibility towards environment impacts the financial performance of firms.Design/methodology/approachThe sample comprises 150 listed and non‐listed Indian manufacturing companies. Salience and corporate responsibility towards environment were assessed with the help of standard instruments and the data on financial performance of companies were procured from secondary sources. The study used hybrid models to analyze the data. In the measurement model, the convergent validity of salience and corporate responsibility towards natural environment were ascertained through confirmatory factor analysis. In the structural model, the hypotheses were tested.FindingsControlling the confounding effects of listing status of companies in stock exchanges, findings suggest that higher the salience of the environment, the more favorable is the corporate responsibility towards the environment. The favorable corporate responsibility towards environment increases the financial performance of firms.Practical implicationsBy according salience to the natural environment and adopting responsible environment practices, Indian companies can improve their financial performance.Originality/valueThis study is the first of its kind in India to establish the link among salience of natural environment, corporate responsibility towards natural environment, and financial performance of firms. It reveals that salience accorded to natural environment leads to responsible business practices with respect to the environment that boosts the bottom line of firms.
IgE binding to peanut components by four different techniques: Ara h 2 is the most relevant in peanut allergic children and adults
Authors: Klemans R. J. B. , Liu X. , Knulst A. C. , Knol M. J. , Gmelig‐Meyling F. , Borst E. , Pasmans S. G. M. A. , Knol E. F. 
Published: April 2013

SummaryBackgroundSeveral studies have analysed the diagnostic value of specific IgE (sIgE) for individual peanut allergens. However, little is known about the concordance between different techniques available in both children and adults.ObjectiveTo evaluate the value of individual peanut allergens by different techniques, i.e. multi‐plexed microarray, single‐plexed IgE assay, skin prick test (SPT) and immunoblot in both peanut allergic adults and children.MethodsSensitization patterns to peanut allergens Ara h 1, 2, 3, and 8 were evaluated using four different techniques: multi‐plexed microarray immunoassay, single‐plexed IgE assay, SPT and immunoblot. Twenty‐two peanut allergic adults and 15 children scored on clinical severity according to double‐blind, placebo‐controlled food challenges and 27 atopic control patients were included.ResultsComparable sensitivity values were found between all four techniques in adults, with the highest sensitivity for Ara h 2 (76.2–95.5%, compared to 100% with all techniques in children). The multi‐plexed assay to Ara h 1 (93.3%) demonstrated a higher sensitivity compared with the other three techniques (P = 0.04) in children, but absolute values were perfectly correlated. There were no differences between adults and children. The area under the receiver operating characteristic curve (AUC) of sIgE to Ara h 1 was higher with the multi‐plexed assay compared with the single‐plexed assay (0.91 vs. 0.75). In adults, sIgE to Ara h 1, 2, and 3 was correlated with clinical severity. No such correlation was found in children.Conclusion and Clinical RelevanceIn conclusion, the single‐ and multi‐plexed assay, SPT and immunoblot perform equally in both peanut allergic adults and children, with Ara h 2 being most often recognized with all techniques. Specific IgE to Ara h 1, 2, and 3 in adults was correlated with severity.
The Mechanisms of Space‐Time Association: Comparing Motor and Perceptual Contributions in Time Reproduction
Authors: Fabbri Marco , Cellini Nicola , Martoni Monica , Tonetti Lorenzo , Natale Vincenzo 
Published: April 2013

AbstractThe spatial‐temporal association indicates that time is represented spatially along a left‐to‐right line. It is unclear whether the spatial‐temporal association is mainly related to a perceptual or a motor component. In addition, the spatial‐temporal association is not consistently found using a time reproduction task. Our rationale for this finding is that, classically, a non‐lateralized button for performing the task has been used. Using two lateralized response buttons, the aim of the study was to find a spatial‐temporal association in a time reproduction task. To account for the perceptual component, reference and target stimuli were presented in different spaces through four experiments. In all experiments, a Spatial‐Temporal Association of Response Codes (STEARC) effect was found and this effect was not modulated by the spatial position of both reference and target stimuli. The results suggested that the spatial‐temporal association was mainly derived from the spatial information provided by response buttons, reflecting a motor but not visuospatial influence.
Efficacy and safety of lixisenatide once daily versus placebo in type 2 diabetes insufficiently controlled on pioglitazone (GetGoal‐P)
Authors: Pinget M. , Goldenberg R. , Niemoeller E. , Muehlen‐Bartmer I. , Guo H. , Aronson R. 
Published: April 2013

AimsTo compare the efficacy and safety of once‐daily prandial lixisenatide with placebo in type 2 diabetes mellitus (T2DM) insufficiently controlled by pioglitazone ± metformin.MethodsThis randomized, double‐blind study included a 24‐week main treatment period and a ≥52‐week variable extension period. Patients were randomized 2 : 1 to receive lixisenatide 20 µg once daily or placebo. The primary endpoint was change in glycated haemoglobin (HbA1c) at week 24.ResultsIn total, 484 patients were randomized: 323 to lixisenatide; 161 to placebo. After 24 weeks, lixisenatide once daily significantly improved HbA1c (−0.56% vs. placebo; p < 0.0001) and increased the proportion of patients achieving HbA1c <7% compared with placebo (52.3% vs. 26.4%, respectively; p < 0.0001) and significantly improved fasting plasma glucose (−0.84 mmol/l vs. placebo; p < 0.0001). There was a small decrease in body weight with lixisenatide once daily and a small increase with placebo, with no statistically significant difference between the two groups. Overall, lixisenatide once daily was well tolerated, with a similar proportion of treatment‐emergent adverse events (TEAEs) and serious TEAEs between groups (lixisenatide: 72.4% and 2.5%; placebo: 72.7% and 1.9%). Symptomatic hypoglycaemia rates were also relatively low in both groups (lixisenatide 3.4% and placebo 1.2%), with no severe episodes. Lixisenatide continued to be efficacious and well tolerated during the variable extension period.ConclusionsLixisenatide once daily significantly improved glycaemic control with a low risk of hypoglycaemia, and was well tolerated over 24 weeks and during the long‐term, double‐blind extension period in patients with T2DM insufficiently controlled on pioglitazone ± metformin.
Disrupted Cl− homeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited states
Authors: Deeb Tarek Z. , Nakamura Yasuko , Frost Greg D. , Davies Paul A. , Moss Stephen J. 
Published: April 2013

AbstractThe K+‐Cl− cotransporter type 2 is the major Cl− extrusion mechanism in most adult neurons. This process in turn leads to Cl− influx upon activation of γ‐aminobutyric acid type A (GABAA) receptors and the canonical hyperpolarising inhibitory postsynaptic potential. Several neurological disorders are treated with drugs that target and enhance GABAA receptor signaling, including the commonly used benzodiazepine diazepam and the anesthetic propofol. Some of these disorders are also associated with deficits in GABAA signaling and become less sensitive to therapeutic drugs that target GABAA receptors. To date, it is unknown if alterations in the neuronal Cl− gradient affect the efficacies of diazepam and propofol. We therefore used the in vitro model of glutamate‐induced hyperexcitability to test if alterations in the Cl− gradient affect the efficacy of GABAA modulators. We exclusively utilised the gramicidin perforated‐patch‐clamp configuration to preserve the endogenous Cl− gradient in rat neurons. Brief exposure to glutamate reduced the inhibitory efficacy of diazepam within 5 min, which was caused by the collapse of the Cl− gradient, and not due to reductions in GABAA receptor number. Unlike diazepam, propofol retained its efficacy by shunting the membrane conductance despite the glutamate‐induced appearance of depolarising GABAA‐mediated currents. Similarly, pharmacological inhibition of K+‐Cl− cotransporter type 2 by furosemide disrupted Cl− homeostasis and reduced the efficacy of diazepam but not propofol. Collectively our results suggest that pathological hyperexcitable conditions could cause the rapid accumulation of intracellular Cl− and the appearance of depolarising GABAA‐mediated currents that would decrease the efficacy of diazepam.
Widespread evidence for incipient ecological speciation: a meta‐analysis of isolation‐by‐ecology
Authors: Shafer Aaron B. A. , Wolf Jochen B. W. 
Published: April 2013

AbstractEcologically mediated selection has increasingly become recognised as an important driver of speciation. The correlation between neutral genetic differentiation and environmental or phenotypic divergence among populations, to which we collectively refer to as isolation‐by‐ecology (IBE), is an indicator of ecological speciation. In a meta‐analysis framework, we determined the strength and commonality ofIBEin nature. On the basis of 106 studies, we calculated a mean effect size ofIBEwith and without controlling for spatial autocorrelation among populations. Effect sizes were 0.34 (95%CI0.24–0.42) and 0.26 (95%CI0.13–0.37), respectively, indicating that an average of 5% of the neutral genetic differentiation among populations was explained purely by ecological contrast. Importantly, spatial autocorrelation reducedIBEcorrelations for environmental variables, but not for phenotypes. Through simulation, we showed how the influence of isolation‐by‐distance and spatial autocorrelation of ecological variables can result in false positives or underestimated correlations if not accounted for in theIBEmodel. Collectively, this meta‐analysis showed that ecologically induced genetic divergence is pervasive across time‐scales and taxa, and largely independent of the choice of molecular marker. We discuss the importance of these results in the context of adaptation and ecological speciation and suggest future research avenues.
Does consumption of high‐fructose corn syrup beverages cause obesity in children?
Authors: Morgan R. E. 
Published: April 2013

SummaryWhat is already known about this subject
High Fructose Corn Syrup (HFCS) consumption in the form of beverages has increased among U.S. school‐aged children.
HFCS is a common sweetener found in the U.S. food supply including fruit juices, soft drinks, and sport drinks.
Obesity exposes school‐aged children to preventative health risks.
What this study adds
There is inconclusive scientific evidence to definitively link HFCS beverage consumption in school‐aged children to obesity.
Consumption of HFCS beverages in children may displace consumption of milk.
Many entities contribute to childhood yet limitation of sweetened beverages may decrease obesity in children.
The consumption of high‐fructose corn syrup (HFCS) beverages has increased since the 1970s. At the same time, childhood obesity is on the rise, causing children to be at risk of heart disease, diabetes and other diseases. Healthcare providers have attributed childhood obesity to the consumption of HFCS in the form of beverages. This article will look at the available research and determine if there is scientific evidence underlying the idea that sweetened soft drinks, especially those containing HFCS, could cause or contribute to childhood obesity. A thorough literature search was performed using the ISI Web of Sciences, PubMed and Scopus databases within the years 2006–2012. The search generated 19 results. The articles were screened, and six were deemed eligible: four systematic reviews and two meta‐analyses. Two systematic reviews found that there is no relationship between consumption of HFCS beverages and obesity in children. The other two systematic reviews found possible links between HFCS and childhood obesity. The meta‐analysis articles found that consumption of HFCS beverages can contribute to childhood obesity, and limitation of sweetened beverages may help decrease obesity in children. Available research studies demonstrate inconclusive scientific evidence definitively linking HFCS to obesity in children.