bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Surgical Management of Capsular and Iris Deficiency With Glued Intraocular Lens Technique
Authors: Kumar Dhivya Ashok , Agarwal Amar , Jacob Soosan , Lamba Mandeep , Packialakshmi Sathiya , Meduri Alessandro 
Published: May 2013

PURPOSE:
To determine the outcome after glued aniridia intraocular lens (IOL) and glued IOL with iridoplasty in eyes with combined lens capsular and iris deficiency.

METHODS:
Twenty-seven eyes of 25 patients (6 had congenital aniridia with subluxated cataract and 19 had acquired lens/iris defects) were included. Glued IOL with aniridia IOL (Intra Ocular Care, Gujarat, India) was performed in eyes with total aniridia and iridoplasty with glued IOL with a three-piece foldable IOL (Sofport; Bausch & Lomb, Rochester, NY) was performed in eyes with partial aniridia. The postoperative outcomes were analyzed at follow-up examination (range: 6 to 48 months).

RESULTS:

Eleven eyes underwent glued aniridia IOL and 16 eyes underwent glued IOL with iridoplasty. There was significant improvement in (spectacle) corrected distance visual acuity (CDVA) (
P
= .002). Postoperatively, pigment dispersion on the IOL (n = 1) and raised intraocular pressure was seen in the glued aniridia IOL group and chronic uveitis (n = 1), cystoid macular edema (n = 1), and hyphema (n = 1) in the glued IOL with iridoplasty group. The CDVA remained unchanged in 14 eyes (51.8%) and improved in 13 eyes (48.1%). There was a difference in postoperative CDVA (
P
= .001) between eyes with glued aniridia IOL and glued IOL with iridoplasty. There was no IOL decentration, retinal detachment, corneal decompensation, or endophthalmitis. There was reduction in glare and photophobia.

CONCLUSIONS:
Both glued aniridia IOL and glued IOL/iridoplasty showed good functional and anatomical results with fewer complications in eyes with lens capsule and iris deficiency. However, long-term follow-up is required.

[
J Refract Surg
. 2013;29(5):342–347.]
PD-L1/B7-H1 Regulates the Survival but Not the Function of CD8+ T Cells in Herpes Simplex Virus Type 1 Latently Infected Trigeminal Ganglia
Authors: Jeon Sohyun , St. Leger Anthony J. , Cherpes Thomas L. , Sheridan Brian S. , Hendricks Robert L. 
Published: May 2013

AbstractHSV type 1 (HSV-1)–specific CD8+ T cells provide immunosurveillance of trigeminal ganglion (TG) neurons that harbor latent HSV-1. In C57BL/6 mice, the TG-resident CD8+ T cells are HSV specific and maintain a 1:1 ratio of cells recognizing an immunodominant epitope on viral glycoprotein B (gB498–505-Tet+) and cells reactive to subdominant epitopes (gB-Tet−). The gB-Tet− CD8+ T cells maintain their frequency in TG by balancing a higher rate of proliferation with a correspondingly higher rate of apoptosis. The increased apoptosis is associated with higher expression of programmed death-1 (PD-1) on gB-Tet− CD8+ T cells and the interaction with PD-1 ligand (PD-L1/B7-H1). IFN-γ regulated expression of the PD-1 ligand (PD-L1/B7-H1) on neurons bearing higher copies of latent viral genome. In latently infected TG of B7-H1−/− mice, the number and frequency of PD-1+ gB-Tet− CD8+ T cells increases dramatically, but gB-Tet− CD8+ T cells remain largely nonfunctional and do not provide increased protection from HSV-1 reactivation in ex vivo cultures of latently infected TG. Unlike observations in some chronic infection models, B7-H1 blockade did not increase the function of exhausted gB-Tet− CD8 T cells in latently infected TG.
Concise Review: Heart Regeneration and the Role of Cardiac Stem Cells
Authors: Koudstaal Stefan , Jansen of Lorkeers Sanne J. , Gaetani Roberto , Gho Johannes M.I.H. , van Slochteren Frebus J. , Sluijter Joost P.G. , Doevendans Pieter A. , Ellison Georgina M. , Chamuleau Steven A.J. 
Published: May 2013

Abstract
Acute myocardial infarction leads to irreversible loss of cardiac myocytes, thereby diminishing the pump function of the heart. As a result, the strenuous workload imposed on the remaining cardiac myocytes often gives rise to subsequent cell loss until the vicious circle ends in chronic heart failure (CHF). Thus, we are in need of a therapy that could ameliorate or even reverse the disease progression of CHF. Endogenous regeneration of the mammalian heart has been shown in the neonatal heart, and the discovery that it may still persist in adulthood sparked hope for novel cardioregenerative therapies. As the basis for cardiomyocyte renewal, multipotent cardiac stem/progenitor cells (CSCs) that reside in the heart have been shown to differentiate into cardiac myocytes, smooth muscle cells, and vascular endothelial cells. These CSCs do have the potential to actively regenerate the heart but clearly fail to do so after abundant and segmental loss of cells, such as what occurs with myocardial infarction. Therefore, it is vital to continue research for the most optimal therapy based on the use or in situ stimulation of these CSCs. In this review, we discuss the current status of the cardioregenerative field. In particular, we summarize the current knowledge of CSCs as the regenerative substrate in the adult heart and their use in preclinical and clinical studies to repair the injured myocardium.
Isolation of Human Umbilical Cord Blood Aldehyde Dehydrogenase–Expressing Progenitor Cells that Modulate Vascular Regenerative Functions In Vitro and In Vivo
Authors: Putman David M. , Hess David A. 
Published: May 2013

AbstractThis unit describes the isolation and application of human umbilical cord blood progenitor cells to modulate vascular regenerative functions using in vitro co‐culture systems and in vivo transplantation models. Using aldehyde dehydrogenase as a marker of stem cell function, blood‐derived progenitors can be efficiently purified form human umbilical cord blood using flow cytometry. We describe in vitro approaches to measure cell‐mediated effects on the survival, proliferation, and tube‐forming function of endothelial cells using growth‐rate assays and Matrigel tube‐forming assays. Additionally, we provide a detailed protocol for inducing acute unilateral hindlimb ischemia in immune‐deficient mice to assess progenitor cell–modulated effects on vascular regeneration by tracking the recovery of blood flow using noninvasive laser Doppler perfusion imaging. Collectively, we present combined in vitro and in vivo transplantation strategies for the pre‐clinical assessment of human progenitor cell–based therapies to treat ischemic disease. Curr. Protoc. Stem Cell Biol. 25:2A.10.1‐2A.10.19. © 2013 by John Wiley & Sons, Inc.
State estimation for short‐time switched linear systems under asynchronous switching
Authors: Xiang Weiming , Xiao Jian , Iqbal Muhammad Naveed 
Published: May 2013

SUMMARYIn this note, the state estimation problem for a class of short‐time switched linear systems is investigated. By incorporating the concept of finite‐time stability, an observer is designed to ensure the error dynamics finite‐time stable in the short‐time switching interval under the general asynchronous switching whereas synchronous switching mode is its special case. A numerical example is provided to illustrate the effectiveness of our study in this paper. Copyright © 2013 John Wiley & Sons, Ltd.
Nutritional status and its association with physical fitness, physical activity and parasitological indicators in youths from rural mozambique
Authors: Nhantumbo Leonardo , Ribeiro Maia José António , Dos Santos Fernanda Karina , Jani Ilesh V. , Gudo Eduardo Samo , Katzmarzyk Peter T. , Prista António 
Published: May 2013

ABSTRACTBackgroundLittle information exists about the relationship of nutritional status and motor performance conditional on asymptomatic parasitemia in rural African children.AimsThe aims of this study were to (1) determine if malnourished youths from rural African areas have lower levels of physical fitness (PF) and physical activity (PA) compared to normal weight youths, (2) verify the biological relevance of anthropometric criteria used to classify nutritional status in youth, and (3) determine the prevalence of parasitological indicators, and its association with nutritional status and PF.MethodsThe sample comprised 794 youths (6–17 years) from Calanga, a rural community in Mozambique. PF tests were selected from standardized test batteries, and PA was estimated by accelerometry. Nutritional status was defined according to WHO recommendations for stunting, wasting and normal weight. Parasitological indicators were determined based on stool specimens' analysis.ResultsIn general terms the normal group out‐performed the other nutritional groups (stunted and wasted) for PF. However, no significant differences were found for PA among nutritional groups. There were also no significant differences in prevalence of intestinal parasites.ConclusionsNutritional status was not associated with PA levels or the prevalence of parasitological indicators in youth, but was related to physical performance. Am. J. Hum. Biol. 25:516–523, 2013. © 2013 Wiley Periodicals, Inc.
Compression of 3D mesh sequences by temporal segmentation
Authors: Luo Guoliang , Cordier Frederic , Seo Hyewon 
Published: May 2013

ABSTRACTWe describe a compression method for three‐dimensional animation sequences that has notable advantages over existing techniques. We first aggregate the frame data by similarity and reorganize them into clusters, which results in the sequence split into several motion fragments of varying lengths. To minimize the number of clusters and obtain optimal clustering, we perform frame alignment, which eliminates the “global” rigid transformation from each frame data and use only “pose” when evaluating the similarity between frames. We then apply principal component analysis for each cluster, from which we get coordinates of corresponding frames in a reduced dimension. Because similar frames are considered, the number of coefficients required for each frame becomes smaller; thus, we obtain better dimension reduction for a given reconstruction error. Further, we perform intracluster compression based on linear coding. Because every motion fragment presents similar frames, conventional linear predictive coding can be replaced by key frame‐based linear coding to achieve minimal reconstruction error. Results show that our method can obtain a high compression ratio, with a limited reconstruction error. Copyright © 2013 John Wiley & Sons, Ltd.
A Validated Normal Phase LC Method for Enantiomeric Separation of Rasagiline Mesylate and Its (S)‐Enantiomer on Cellulose Derivative‐Based Chiral Stationary Phase
Authors: Sunil Reddy P. , Sudhakar Babu K. , Kumar Navneet 
Published: May 2013

ABSTRACTA simple, sensitive, and robust normal‐phase isocratic HPLC‐UV method was developed and validated for the enantiomeric separation of rasagiline mesylate and its (S)‐enantiomer. The rasagiline and its (S)‐enantiomer were resolved on a Chiralcel‐OJ‐H (4‐methylbenzoate cellulose coated on silica) column using a mobile phase consisting of n‐hexane:isopropyl alcohol:ethanol:diethyl amine (96:2:2:0.01) at a flow rate of 1.0 ml/min. The column temperature was maintained at 27 °C and elution was monitored at 215 nm. The resolution (Rs) between the enantiomers was found to be more than 2.0. The limit of detection and the limit of quantification of the (S)‐enantiomer were found to be 0.35 and 1.05 µg/ml, respectively. The developed method was validated as per ICH guidelines with respect to linearity, limit of detection and quantification, accuracy, precision, and robustness—and satisfactory results were obtained. The sample solution and mobile phase were found to be stable up to 48 h. The method is useful for routine evaluation of the quality of rasagiline mesylate in bulk drug‐manufacturing units. Chirality 25:324–327, 2013. © 2013 Wiley Periodicals, Inc.
Stereoselective Degradation and Microbial Epimerization of Triadimenol in Soils
Authors: Li Zhaoyang , Li Qiaoling , Zhao Jiahe , Wang Weixiao 
Published: May 2013

ABSTRACTTriadimenol is a widely used triazole fungicide and consists of four stereoisomers with1R,2S,1S,2R,1R,2R, and1S,2Sconfigurations. The trans‐enantiomeric pair (1R,2S‐isomer and1S,2R‐isomer) is also called triadimenol‐A and the cis‐enantiomeric pair (1R,2R‐isomer and1S,2S‐isomer) triadimenol‐B. In this study, the stereoselective degradation and chiral stability of triadimenol in two soils were investigated in details. The dissipation of technical triadimenol, a 6:1 mixture of triadimenol‐A and triadimenol‐B, showed significant epimerization from triadimenol‐A to triadimenol‐B occurred along with the dissipation process. The degradation exhibited some stereoselectivity, resulting in a concentration order of1S,2S > 1R,2R > 1R,2S > 1S,2Ror1S,2S > 1R,2R > 1S,2R > 1R,2Sat the end of the 100 days incubation for Baoding soil or Wuhan soil, respectively. Further incubation of triadimenol‐B revealed no epimerization, i.e. triadimenol‐B was configurationally stable in soil, and1R,2R‐triadimenol degraded slightly slower in the former part and slightly faster in the later part of the incubation than1S,2S‐triadimenol. Moreover, by incubation of enantiopure1S,2R‐triadimenol and1R,2S‐triadimenol, the results documented the epimerization for each enantiomer occurred at both C‐1 and C‐2 positions. Finally, the present work also documented that the enantiomerization reaction for all the four stereoisomers was nearly negligible in the soils. Chirality 25:355‐360:, 2013. © 2013 Wiley Periodicals, Inc.
Stereoselective Accumulation of Propranolol Enantiomers in K562 and K562/ADR Cells
Authors: Zheng Xiao‐Li , Yu Qin‐Qin , Wang Yi , Zeng Su 
Published: May 2013

ABSTRACTThe stereoselective uptake of propranolol enantiomers was investigated by using the K562 and K562 adriamycin‐resistant cell line (K562/ADR) as a model. An enantioselective RP‐HPLC method was applied to determine the accumulation of propranolol (PPL) stereoisomers in K562 and K562/ADR cells. The concentration, time and temperature dependent studies showed that the accumulation of S‐(−)‐PPL was higher than R‐(+)‐PPL in K562 cells and uptake of R‐(+)‐PPL was significantly higher than that of S‐(−)‐PPL in K562/ADR cells. The results indicate the enantioselective accumulation of propranolol enantiomers in K562 and K562 / ADR cells. Chirality 25:361–364, 2013. © 2013 Wiley Periodicals, Inc.
Polymer Bulk Heterojunction Solar Cells with PEDOT:PSS Bilayer Structure as Hole Extraction Layer
Authors: Kim Wanjung , Kim Namhun , Kim Jung Kyu , Park Insun , Choi Yeong Suk , Wang Dong Hwan , Chae Heeyeop , Park Jong Hyeok 
Published: May 2013

AbstractA high current density obtained in a limited, nanometer‐thick region is important for high efficiency polymer solar cells (PSCs). The conversion of incident photons to charge carriers only occurs in confined active layers; therefore, charge‐carrier extraction from the active layer within the device by using solar light has an important impact on the current density and the related to power conversion efficiency. In this study, we observed a surprising result, that is, extracting the charge carrier generated in the active layer of a PSC device, with a thickness‐controlled PEDOT:PSS bilayer that acted as a hole extraction layer (HEL), yielded a dramatically improved power conversion efficiency in two different model systems (P3HT:PC60BM and PCDTBT:PC70BM). To understand this phenomenon, we conducted optical strength simulation, photocurrent–voltage measurements, incident photon to charge carrier efficiency measurements, ultraviolet photoelectron spectroscopy, and AFM studies. The results revealed that approximately 60 nm was the optimum PEDOT:PSS bilayer HEL thickness in PSCs for producing the maximum power conversion efficiency.
The research–practice Gap: Bridging the schism between eating disorder researchers and practitioners
Authors: Lilienfeld Scott O. , Ritschel Lorie A. , Lynn Steven Jay , Brown Amanda P. , Cautin Robin L. , Latzman Robert D. 
Published: May 2013

AbstractObjective:The field of eating disorders (EDs) treatment has been beset by a marked disjunction between scientific evidence and clinical application. We describe the nature and scope of the research–practice gap in the ED field.Method:We draw on surveys and broader literature to better understand the research–practice gap in ED treatment and reasons for resistance to evidence‐based practice.Results:We identify three sources of the research–practice gap: (1) attitudinal factors, (2) differences in the definition of “evidence,” and (3) cognitive factors, especially naïve realism and confirmation bias. We affirm the role of science as a safeguard against human fallibility and as a means of bridging the research–practice gap, and delineate key principles of scientific thinking for ED researchers and practitioners.Discussion:We conclude with proposals for narrowing the research–practice gap in ED treatment and enhancing the quality of interventions for ED clients. © 2013 by Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:386–394)
Avoidant restrictive food intake disorder: An illustrative case example
Authors: Bryant‐Waugh Rachel 
Published: May 2013

AbstractAvoidant/restrictive food intake disorder (ARFID) is a new diagnostic category in DSM‐5. Although replacing Feeding Disorder of Infancy or Early Childhood, it is not restricted to childhood presentations. In keeping with the broader aim of revising and updating criteria and text to better reflect lifespan issues and clinical expression across the age range, ARFID is a diagnosis relevant to children, adolescents, and adults. This case example of a 13‐year old boy with ARFID illustrates key issues in diagnosis and treatment planning. The issues discussed are not exhaustive, but serve as a guide for central diagnostic and treatment issues to be considered by the clinician. It is anticipated that the inclusion of specific criteria for ARFID as a category within Feeding and Eating Disorders in DSM‐5 will stimulate research into its typology, prevalence, and incidence in different populations and facilitate the development of effective, evidence‐based interventions for this patient group. © 2013 by Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:420–423)
Bone health in adolescent females with anorexia nervosa: What is a clinician to do?
Authors: Katzman Debra K. , Misra Madhusmita 
Published: May 2013

AbstractThe objective of this case report is to present a pharmacologic strategy for treatment of adolescents with anorexia nervosa (AN) and low bone mineral density (BMD). We present a 17.5‐year‐old girl with a 3‐year history of AN and longstanding inability to optimize nutrition and gain weight, and a decrease over time in her already low BMD. A year after treatment with the 17‐β estradiol patch (100 mcg twice weekly) with cyclic oral progesterone (2.5 mg medroxyprogesterone acetate daily for days 1–10 of every month), her spine and hip BMD Z‐scores improved, and a further decrease was prevented. This novel treatment is a consideration for girls with AN at greatest risk for low BMD. Adolescents with AN are at risk for low BMD, and the most effective treatment is weight and menses restoration, which can be difficult to attain and to sustain. Recent studies have shown promising results with pharmacological therapy for low BMD in AN. This article discusses current concepts related to bone loss in AN, and new pharmacologic considerations for adolescents at greatest risk for low BMD. © 2013 by Wiley Periodicals, Inc.
A systematic review of evidence for psychological treatments in eating disorders: 2005–2012
Authors: Hay Phillipa 
Published: May 2013

AbstractObjective:To update new evidence for psychotherapies in eating disorders (EDs) since 2005–September 2012.Method:Completed and published in the English language randomized controlled trials (RCTs) were identified by SCOPUS search using terms “bulimia” or “binge eating disorder” (BED) or “anorexia nervosa” (AN) or “eating disorder” and “treatment,” and 36 new RCTs met inclusion criteria.Results:There has been progress in the evidence for family based treatment in adolescents with AN, for cognitive behavior therapy (CBT) in full and guided forms, and new modes of delivery for bulimia nervosa (BN), BED, and eating disorder not otherwise specified with binge eating. Risk of bias was low to moderate in 22 (61%) of RCTs.Discussion:The evidence base for AN has improved and CBT has retained and extended its status as first‐line therapy for BN. However, further research is needed, in particular noninferiority trials of active therapies and the best approach to addressing ED features and weight management in co‐morbid BED and obesity. © 2013 by Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:462–469)
Biological therapies for eating disorders
Authors: Mitchell James E. , Roerig James , Steffen Kristine 
Published: May 2013

AbstractObjective:To provide a comprehensive review of pharmacotherapy and other biological treatments for eating disorders.Method:Literature on this topic was systematically reviewed.Results:The bulimia nervosa (BN) literature underscores the utility of antidepressants, particularly SSRIs, in improving the symptoms of the disorder. The literature on binge eating disorder supports efficacy on reduction in binge eating frequency for a variety of compounds. However, such compounds have only modest effects on weight. Certain antiepileptic agents such as topiramate, if tolerated, are probably more useful in terms of weight loss. The number of controlled trials in patients with anorexia nervosa (AN) in particular has been quite small, and recent meta‐analyses show disappointing results using atypical antipsychotics in AN.Discussion:The pharmacological treatment of eating disorders remains an underdeveloped field although drug therapy clearly plays a role in the treatment of those with BN and binge eating disorder. Other biological therapies have not been adequately studied. © 2013 by Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:470–477)
Eating disorder prevention: Current evidence‐base and future directions
Authors: Stice Eric , Becker Carolyn Black , Yokum Sonja 
Published: May 2013

AbstractObjective:This narrative review sought to (a) characterize prevention programs that have produced reliable, reproducible, and clinically meaningful effects in efficacy trials, (b) discuss effectiveness trials that have tested whether prevention programs produce intervention effects under ecologically valid real‐world conditions, (c) discuss dissemination efforts and research on dissemination, and (d) offer suggestions regarding directions for future research in this field.Conclusion:A literature revealed that 6 prevention programs have produced significant reductions in eating disorder symptoms through at least 6‐month follow‐up and that 2 have significantly reduced future eating disorder onset. Effectiveness trials indicate that 2 prevention programs have produced effects under ecologically valid conditions that are only slightly attenuated. Although there have been few dissemination efforts, evidence suggests that a community participatory approach is most effective. Lastly, it would be useful to develop programs that produce larger and more persistent reductions in eating disorder symptoms and eating disorder onset, focus more on effectiveness trials that confirm that prevention programs produce clinically meaningful effects under real‐world conditions, conduct meditational, mechanisms of action, and moderator research that provides stronger support for the intervention theory of prevention programs, and investigate the optimal methods of disseminating and implementing evidence‐based prevention programs. © 2013 by Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:478–485)