bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Cationic Gold‐ and Silver‐Catalyzed Cycloisomerizations of Propargylic Ureas: A Selective Entry to Oxazolidin‐2‐imines and Imidazolidin‐2‐ones.
Authors: Pereshivko Olga P. , Peshkov Vsevolod A. , Jacobs Jeroen , Van Meervelt Luc , Van der Eycken Erik V. 
Published: August 2013

AbstractApplication of cationic Au(I) catalysis generally results in the formation of oxazolidin product (III) as a major one while the application of AgOTf selectively provides the N‐cyclized imidazolidin (IV).
ChemInform Abstract: Iron(II)‐Catalyzed Intramolecular Aminohydroxylation of Olefins with Functionalized Hydroxylamines.
Authors: Liu Guan‐Sai , Zhang Yong‐Qiang , Yuan Yong‐An , Xu Hao 
Published: August 2013

AbstractNovel Fe(II) complexes are applied to the diastereoselective intramolecular aminohydroxylation of olefins bearing a functionalized hydroxylamine moiety.
ChemInform Abstract: Synthesis, Crystal Structure and Fe3+ Recognition of Novel Triazolethione Schiff Base Derivatives.
Authors: Yu Jing‐Wen , Wang Yong , Wang Yu‐Bo , Wang Chun‐Feng 
Published: August 2013

AbstractCompound (IVe) can selectively recognize Fe3+ and a 1:1 stoichiometric complex is formed between the receptor and the cation.
ChemInform Abstract: Asymmetric Organocatalytic Michael—Hemiacetalization Reaction: Access to Chiral Spiro cis‐δ‐Lactones by in situ Oxidation of Spiro δ‐Lactols.
Authors: Wei Mo‐Hui , Zhou Yi‐Rong , Gu Liang‐Hu , Luo Fan , Zhang Fang‐Lin 
Published: August 2013

AbstractThe 1‐nitromethylcycloalkanols (I) and (VI) react with α,β‐unsaturated aldehydes to give spiro cis‐δ‐lactol intermediates.
ChemInform Abstract: Copper‐Catalyzed Direct ortho‐Alkylation of N‐Iminopyridinium Ylides with N‐Tosylhydrazones.
Authors: Xiao Qing , Ling Lin , Ye Fei , Tan Renchang , Tian Leiming , Zhang Yan , Li Yuxue , Wang Jianbo 
Published: August 2013

AbstractThe mild operationally simple title reaction proceeds using an inexpensive catalyst without any ligand.
ChemInform Abstract: Cyclization and N‐Iodosuccinimide‐Induced Electrophilic Iodocyclization of 3‐Aza‐1,5‐enynes to Synthesize 1,2‐Dihydropyridines and 3‐Iodo‐1,2‐dihydropyridines.
Authors: Xin Xiaoyi , Wang Dongping , Wu Fan , Li Xincheng , Wan Boshun 
Published: August 2013

AbstractA metal‐free approach to synthesize the title compounds selectively from readily available 3‐aza‐1,5‐enynes is developed.
ChemInform Abstract: Synthesis of 3,4‐Dihydroisoquinolin‐1‐ones from N‐Boc‐(β‐Arylethyl)‐carbamates via Isocyanate Intermediates.
Authors: In Jinkyung , Hwang Soonho , Kim Changhun , Seo Jae Hong , Kim Sanghee 
Published: August 2013

AbstractThe title reaction proceeds in good yields and with high regioselectivities for electron‐rich aromatic substrates.
ChemInform Abstract: A One‐Pot Synthesis of Tetrahydroisoquinolin‐4‐ols via a Novel Acid‐Catalyzed Rearrangement of 5‐Aryloxazolidines.
Authors: Moshkin Vladimir S. , Sosnovskikh Vyacheslav Ya. 
Published: August 2013

AbstractCycloaddition of aromatic aldehydes with the azomethine ylide derived from sarcosine and formaldehyde provides 5‐aryloxazolidine intermediates.
ChemInform Abstract: Vinylic Amino Group Activation: A New and General Strategy Leading to Functionalized Fused Heteroaromatics.
Authors: Sunke Rajnikanth , Adepu Raju , Kapavarapu Ravikumar , Chintala Swetha , Meda Chandana Lakshmi Teja , Parsa Kishore V. L. , Pal Manojit 
Published: August 2013

AbstractWith a view to find novel inhibitors of phosphodiesterase 4 (PDE4), a series of tetracyclic heteroaromatics (IV) and (VII) is prepared by intramolecular cyclization of corresponding amines (III) and (VI).
ChemInform Abstract: New Heterocyclic Systems Based on 5,6,7,8‐Tetrahydroisoquinolines
Authors: Sirakanyan S. N. , Kartsev V. G. , Hovakimyan A. A. , Noravyan A. S. , Shakhatuni A. A. 
Published: August 2013

Abstractsynthesis and characterization
ChemInform Abstract: Synthesis of 6‐Acetyl‐1‐methyl‐3‐oxo‐5,8‐diphenyl‐2‐azabicyclo [2.2.2]octane‐4‐carbonitrile
Authors: Nosova N. V. , Vagapov A. V. , Slepukhin P. A. , Gein V. L. 
Published: August 2013

Abstractvia a novel type of cascade process
ChemInform Abstract: Synthesis of Novel [1,2,4]Triazino[5,6‐f]‐1,10‐phenanthrolines Based on the Azolyl‐1‐carboxamidrazones.
Authors: Bunev A. S. , Sukhonosova E. V. , Statsyuk V. E. , Ostapenko G. I. , Purygin P. P. 
Published: August 2013

AbstractA convenient method for the synthesis of previously unknown azolyl‐substituted triazinophenanthrolines (IV) as promising ligands is given.
ChemInform Abstract: General Synthetic Approach to Functionalized Dihydrooxepines.
Authors: Nicolaou K. C. , Yu Ruocheng , Shi Lei , Cai Quan , Lu Min , Heretsch Philipp 
Published: August 2013

AbstractA three step reaction sequence consisting of an initial Baeyer—Villiger oxidation followed by enol phosphate ester formation and reduction is described.
ChemInform Abstract: Asymmetric β‐Boration of α,β‐Unsaturated Carbonyl Compounds with Chiral Rh[bis(oxazolinyl)phenyl] Catalysts.
Authors: Toribatake Kenji , Zhou Li , Tsuruta Ayae , Nishiyama Hisao 
Published: August 2013

AbstractChiral rhodium[bis(oxazolinyl)phenyl] complexes exhibit high catalytic activity for the enantioselective β‐boration of α,β‐unsaturated esters, ketones, and amides.
ChemInform Abstract: FeCl3‐Mediated Arylation of α‐Hydroxyphosphonates with Unactivated Arenes: Pseudo‐Umpolung in Allylic Phosphonates.
Authors: Pallikonda Gangaram , Chakravarty Manab 
Published: August 2013

AbstractA simple and mild protocol for the synthesis of phosphonates from readily accessible starting materials is presented.
ChemInform Abstract: Synthesis of (α,α‐Difluoropropargyl)phosphonates via Aldehyde‐to‐Alkyne Homologation.
Authors: Pajkert Romana , Roeschenthaler Gerd‐Volker 
Published: August 2013

AbstractAn efficient and novel synthetic methodology for the synthesis of different substituted propargyl phosphonates is developed.
ChemInform Abstract: Synthesis of Phosphonate Analogues of Nucleotides with a 2,5‐Dihydro‐1,2‐oxaphospholene Carbon Skeleton.
Authors: Brel V. K. 
Published: August 2013

AbstractElectrophilic halogenation of allenyl phosphonates such as (I) and (VI) is accompanied by a heterocyclization involving the phosphonate group to furnish representatives of a new type of phosphonate analogues of nucleotides [cf.
ChemInform Abstract: Near‐Infrared Quantum Cutting Platform in Thermally Stable Phosphate Phosphorus for Solar Cells.
Authors: Liu Tzu‐Chen , Zhang Gongguo , Qiao Xuebin , Wang Jing , Seo Hyo Jin , Tsai Din‐Ping , Liu Ru‐Shi 
Published: August 2013

AbstractThe photoluminescent properties of Tb3+/Yb3+‐, Ce3+/Tb3+/Yb3+‐, and Eu2+/Yb3+‐doped KSrPO4 are investigated by photoluminescence excitation and emission spectroscopy.
Konversionsmaterialien für die Energiespeicherung
Authors: Fichtner Maximilian 
Published: August 2013

AbstractKonversionsmaterialien stellen aus heutiger Sicht die einzige Option dar, um bei Wasserstoffspeichern und Batterien deutlich höhere gravimetrische und volumetrische Energiedichten zu erzielen. Trotz einiger technischer Schwierigkeiten, wie die noch unzureichende Reversibilität und kinetische Barrieren, sind sie ein lohnendes Forschungs‐ und Entwicklungsobjekt mit der Perspektive, wesentliche Fortschritte bei der Energiespeicherung zu erreichen. Neue Syntheseansätze bei Batterien zeigen, dass über einfache festkörperchemische Verfahren komplexe Strukturen mit hoher Funktionalität erhalten werden können, die deutlich verbesserte Eigenschaften aufweisen.
Starker Tobak
Authors: Streller Sabine , Roth Klaus 
Published: August 2013

AbstractDen aktiven Inhaltsstoff des Tabaks, das Nikotin, synthetisiert die Pflanze ursprünglich als Schutz gegen Schädlinge. Nikotin übersteht die harschen Bedingungen in einer brennenden Zigarette und bindet wenige Sekunden nach dem ersten Zug an bestimmte Acetylcholin‐Rezeptoren im Nervensystem des Rauchers. Es ist das Nikotin, das Raucher so extrem abhängig macht. Auf der anderen Seite werden die meisten mit dem Rauchen zusammenhängenden Krankheiten nicht durch Nikotin, sondern durch andere Komponenten im Tabakrauch verursacht. Daraufhin wurden rauchfreie Produkte wie elektronische Zigaretten entwickelt, die potentiell ein geringeres Risiko darstellen. So kann heute jeder einzelne Raucher eine faktenbasierte Entscheidung treffen, ob überhaupt und wenn ja, wie er das Nikotin aufnimmt.
A Bayesian nonparametric goodness of fit test for right censored data based on approximate samples from the beta‐Stacy process
Authors: Al Labadi Luai , Zarepour Mahmoud 
Published: August 2013

AbstractIn recent years, Bayesian nonparametric statistics has received extraordinary attention. The beta‐Stacy process, a generalization of the Dirichlet process, is a fundamental tool in studying Bayesian nonparametric statistics. In this article, we derive a simple, yet efficient, way to simulate the beta‐Stacy process. We compare the efficiency of the new approximation to several other well‐known approximations, and we demonstrate a significant improvement. Using the Kolmogorov distance and samples from the beta‐Stacy process, a Bayesian nonparametric goodness of fit test is proposed. The proposed test is very general in the sense that it can be applied to censored and non‐censored observations. Some illustrative examples are included. 41: 466–487; 2013 © 2013 Statistical Society of Canada
Clinical activity of ipilimumab for metastatic uveal melanoma
Authors: Luke Jason J. , Callahan Margaret K. , Postow Michael A. , Romano Emanuela , Ramaiya Nikhil , Bluth Mark , Giobbie‐Hurder Anita , Lawrence Donald P. , Ibrahim Nageatte , Ott Patrick A. , Flaherty Keith T. , Sullivan Ryan J. , Harding James J. , D'Angelo Sandra , Dickson Mark , Schwartz Gary K. , Chapman Paul B. , Wolchok Jedd D. , Hodi F. Stephen , Carvajal Richard D. 
Published: August 2013

BACKGROUNDUveal melanoma exhibits a high incidence of metastases; and, to date, there is no systemic therapy that clearly improves outcomes. The anticytotoxic T‐lymphocyte–associated protein 4 (anti‐CTLA‐4) antibody ipilimumab is a standard of care for metastatic melanoma; however, the clinical activity of CTLA‐4 inhibition in patients with metastatic uveal melanoma is poorly defined.METHODSTo assess ipilimumab in this setting, the authors performed a multicenter, retrospective analysis of 4 hospitals in the United States and Europe. Clinical characteristics, toxicities, and radiographic disease burden, as determined by central, blinded radiology review, were evaluated.RESULTSThirty‐nine patients with uveal melanoma were identified, including 34 patients who received 3 mg/kg ipilimumab and 5 who received 10 mg/kg ipilimumab. Immune‐related response criteria and modified World Health Organization criteria were used to assess the response rate (RR) and the combined response plus stable disease (SD) rate after 12 weeks, after 23 weeks, and overall (median follow‐up, 50.4 weeks [12.6 months]). At week 12, the RR was 2.6%, and the response plus SD rate was 46.%; at week 23, the RR was 2.6%, and the response plus SD rate was 28.2%. There was 1 complete response and 1 late partial response (at 100 weeks after initial SD) for an immune‐related RR of 5.1%. Immune‐related adverse events were observed in 28 patients (71.8%) and included 7 (17.9%) grade 3 and 4 events. Immune‐related adverse events were more frequent in patients who received 10 mg/kg ipilimumab than in those who received 3 mg/kg ipilimumab. The median overall survival from the first dose of ipilimumab was 9.6 months (95% confidence interval, 6.3‐13.4 months; range, 1.6‐41.6 months). Performance status, lactate dehydrogenase level, and an absolute lymphocyte count ≥1000 cells/μL at week 7 were associated significantly with survival.CONCLUSIONSIn this multicenter, retrospective analysis of 4 hospitals in the United States and Europe of patients with uveal melanoma, durable responses to ipilimumab and manageable toxicity were observed. Cancer 2013;119:3687–3695. © 2013 American Cancer Society.
Energy‐efficient task allocation with quality of service provisioning for concurrent applications in multi‐functional wireless sensor network systems
Authors: Li Wei , Delicato Flávia C. , Pires Paulo F. , Zomaya Albert Y. 
Published: August 2013

SUMMARYMulti‐functional wireless sensor network (WSN) system is a new design trend of WSNs, which are evolving from dedicated application‐specific systems to an integrated infrastructure that supports the execution of multiple concurrent applications. Such system offers inherent advantages in terms of cost and flexibility because it allows the effective utilization of available sensors and resource sharing among multiple applications. However, sensor nodes are very constrained in resources, mainly regarding their energy. Therefore, the usage of such resources needs to be carefully managed, and the sharing with several applications imposes new challenges in achieving energy efficiency in these networks. In order to exploit the full potential of multi‐functional WSN systems, it is crucial to design mechanisms that effectively allocate tasks onto sensors so that the entire system lifetime is maximized while meeting various application requirements. However, it is likely that the requirements of different applications cannot be simultaneously met. In this paper, we present the Multi‐Application Requirements Aware and Energy Efficiency algorithm as a new resource allocation heuristic for multi‐functional WSN system to maximize system lifetime subject to various application requirements. The heuristic effectively deals with different quality of service parameters (possibly conflicting) trading those parameters and exploiting heterogeneity of multiple WSNs. Copyright © 2013 John Wiley & Sons, Ltd.
Assigning cells to switches in cellular mobile networks using hybridizing API algorithm and Tabu Search
Authors: Debbat F. , Bendimerad F. T. 
Published: August 2013

SUMMARYCells assignment to switches plays an important role in the area of resource management in cellular network. Efficient homing of cells to switches can have a significant impact on handoff and cabling costs. This problem is an NP‐hard problem, which cannot be solved by conventional optimization algorithms. It is therefore necessary to use metaheuristic methods to solve it. This research proposes a hybrid heuristic approach for further improving the quality of solutions. This approach applies API ant algorithm in combination with one of the best heuristics used to solve this problem: Tabu Search. A key element in the success of this hybrid approach is the use simultaneously an intensified research on several areas of research space. The implementation of these algorithms has been subject to extensive tests. In comparison with previous research, the proposed method is efficient, regarding quality of solutions provided for moderate‐sized and large‐sized cellular mobile networks. Copyright © 2013 John Wiley & Sons, Ltd.
Study on Action Mechanism of 1‐(4‐Methoxy‐2‐Methylphenyl)Piperazine (MMPP) in Acquisition, Formation, and Consolidation of Memory in Mice
Authors: Navarrete Andrés , Flores‐Machorro Francisco X. , Téllez‐Ballesteros Ruth I. , Alfaro‐Romero Alejandro , Balderas José Luis , Reyes Adelfo 
Published: August 2013

Abstract

Preclinical Research

In the present study, the mechanism of action of MMPP (1‐(4‐methoxy‐2‐methylphenyl) piperazine) in the acquisition (pretraining administration), formation (posttraining administration), and consolidation (pretest administration) of memory was assessed in the passive avoidance test using a short‐ and long‐term memory protocol in mice. MMPP modified avoidance in the acquisition and formation of memory protocols but not in the consolidation protocol. Scopolamine (0.1 mg/kg i.p.), dizocilpine (0.003 mg/kg i.p.), and buspirone (0.1 mg/kg i.p.) completely inhibited MMPP‐induced effects on memory acquisition and partially inhibited memory formation in the short‐term but not long‐term paradigm. This suggested that cholinergic, N‐methyl‐D‐aspartate (NMDA) and 5‐hydroxytryptamine‐1A (5‐HT1A) receptors were implicated in the MMPP‐induced improvements in memory. The sedative, anxiolytic, motor impairment, myorelaxant, and anticonvulsive (pentylenetetrazole‐induced seizures) properties of MMPP were also assessed with the compound only showing a nondose‐dependent myorelaxation. These results suggest that MMPP can enhance acquisition and formation, but not consolidation, of memory in short‐term and long‐term protocol via cholinergic, NMDA‐glutamatergic, and 5‐HT1A receptors.
Region‐specific regulation of posterior axial elongation during vertebrate embryogenesis
Authors: Neijts Roel , Simmini Salvatore , Giuliani Fabrizio , van Rooijen Carina , Deschamps Jacqueline 
Published: August 2013

ABSTRACTBackground: The vertebrate body axis extends sequentially from the posterior tip of the embryo, fueled by the gastrulation process at the primitive streak and its continuation within the tailbud. Anterior structures are generated early, and subsequent nascent tissues emerge from the posterior growth zone and continue to elongate the axis until its completion. The underlying processes have been shown to be disrupted in mouse mutants, some of which were described more than half a century ago. Results: Important progress in elucidating the cellular and genetic events involved in body axis elongation has recently been made on several fronts. Evidence for the residence of self‐renewing progenitors, some of which are bipotential for neurectoderm and mesoderm, has been obtained by embryo‐grafting techniques and by clonal analyses in the mouse embryo. Transcription factors of several families including homeodomain proteins have proven instrumental for regulating the axial progenitor niche in the growth zone. A complex genetic network linking these transcription factors and signaling molecules is being unraveled that underlies the phenomenon of tissue lengthening from the axial stem cells. The concomitant events of cell fate decision among descendants of these progenitors begin to be better understood at the levels of molecular genetics and cell behavior. Conclusions: The emerging picture indicates that the ontogenesis of the successive body regions is regulated according to different rules. In addition, parameters controlling vertebrate axial length during evolution have emerged from comparative experimental studies. It is on these issues that this review will focus, mainly addressing the study of axial extension in the mouse embryo with some comparison with studies in chick and zebrafish, aiming at unveiling the recent progress, and pointing at still unanswered questions for a thorough understanding of the process of embryonic axis elongation. Developmental Dynamics 243:88–98, 2014. © 2013 Wiley Periodicals, Inc.
How are plant and fungal communities linked to each other in belowground ecosystems? A massively parallel pyrosequencing analysis of the association specificity of root‐associated fungi and their host plants
Authors: Toju Hirokazu , Sato Hirotoshi , Yamamoto Satoshi , Kadowaki Kohmei , Tanabe Akifumi S. , Yazawa Shigenobu , Nishimura Osamu , Agata Kiyokazu 
Published: August 2013

AbstractIn natural forests, hundreds of fungal species colonize plant roots. The preference or specificity for partners in these symbiotic relationships is a key to understanding how the community structures of root‐associated fungi and their host plants influence each other. In an oak‐dominated forest in Japan, we investigated the root‐associated fungal community based on a pyrosequencing analysis of the roots of 33 plant species. Of the 387 fungal taxa observed, 153 (39.5%) were identified on at least two plant species. Although many mycorrhizal and root‐endophytic fungi are shared between the plant species, the five most common plant species in the community had specificity in their association with fungal taxa. Likewise, fungi displayed remarkable variation in their association specificity for plants even within the same phylogenetic or ecological groups. For example, some fungi in the ectomycorrhizal family Russulaceae were detected almost exclusively on specific oak (Quercus) species, whereas other Russulaceae fungi were found even on “non‐ectomycorrhizal” plants (e.g., Lyonia and Ilex). Putatively endophytic ascomycetes in the orders Helotiales and Chaetothyriales also displayed variation in their association specificity and many of them were shared among plant species as major symbionts. These results suggest that the entire structure of belowground plant–fungal associations is described neither by the random sharing of hosts/symbionts nor by complete compartmentalization by mycorrhizal type. Rather, the colonization of multiple types of mycorrhizal fungi on the same plant species and the prevalence of diverse root‐endophytic fungi may be important features of belowground linkage between plant and fungal communities.
Generalized additive mixed models for disentangling long‐term trends, local anomalies, and seasonality in fruit tree phenology
Authors: Polansky Leo , Robbins Martha M. 
Published: August 2013

AbstractQuantifying temporal patterns of ephemeral plant structures such as leaves, flowers, and fruits gives insight into both plant and animal ecology. Different scales of temporal changes in fruits, for example within‐ versus across‐year variability, are driven by different processes, but are not always easy to disentangle. We apply generalized additive mixed models (GAMMs) to study a long‐term fruit presence–absence data set of individual trees collected from a high‐altitude Afromontane tropical rain forest site within Bwindi Impenetrable National Park (BINP), Uganda. Our primary aim was to highlight and evaluateGAMMmethodology, and quantify both intra‐ and interannual changes in fruit production. First, we conduct several simulation experiments to study the practical utility of model selection and smooth term estimation relevant for disentangling intra‐ and interannual variability. These simulations indicate that estimation of nonlinearity and seasonality is generally accurately identified using asymptotic theory. Applied to the empirical data set, we found that the forest‐level fruiting variability arises from both regular seasonality and significant interannual variability, with the years 2009–2010 in particular showing a significant increase in the presence of fruits‐driven by increased productivity of most species, and a regular annual peak associated occurring at the end of one of the two dry seasons. Our analyses illustrate a statistical framework for disentangling short‐term increases/decreases in fruiting effort while pinpointing specific times in which fruiting is atypical, providing a first step for assessing the impacts of regular and irregular (e.g., climate change) abiotic covariates on fruiting phenology. Some consequences of the rich diversity of fruiting patterns observed here for the population biology of frugivores inBINPare also discussed.