bluuebunny/crossref_metadata_2025_split huggingface dataset:
CANNABIS NA DOR CRÔNICA INTRATÁVEL CAUSADA POR RETROPULSÃO DE IMPLANTE METÁLICO CERVICAL: RELATO DE CASO
Authors: Ribeiro Issy Sarah , Teixeira Costa Simon , Silva Lobo Nayara , Oliveira Santos Vinícius 
Published: August 2024

Nas cirurgias de coluna, especialmente, cervical, são adotadas técnicas e abordagens para minimizar riscos de lesão a estruturas circunvizinhas, com o intuito de auxiliar a colocação precisa de implantes metálicos e evitar danos a essas estruturas. A lesão esofágica associada a neuropatia craniana poderia decorrer de uma complicação secundária à lesão ou à intervenção cirúrgica na coluna cervical. Projeto aprovado pelo Comitê de Ética em Pesquisa (CEP) Leide das Neves Ferreira, parecer número 6126359. O presente artigo se compromete em apresentar, na forma de relato, um caso de compressão de raiz cervical submetido a tratamento cirúrgico, que evoluiu com complicações no pós-operatório envolvendo dor crônica, lesão esofágica por material de síntese e perda de função causada por lesão de nervos cranianos. Tendo em vista que os efeitos terapêuticos da planta Cannabis envolvem ação analgésica, anti-inflamatória e neuroprotetora, esse foi o tratamento proposto e realizado para o caso. Os autores definem como objetivo primário discutir os possíveis efeitos terapêuticos da Cannabis em um caso raro de dor crônica intratável, lesão esofágica e neuropatia craniana após abordagem cirúrgica na coluna cervical.
STRATEGI GURU PENDIDIKAN AGAMA ISLAM DALAM MENINGKATAKAN KECERDASAN SPIRITUAL PESERTA DIDIK DI SMAN 5 KUPANG
Authors: Nuraini Hamzah  , Anton  , Fazlur Rahman  
Published: August 2024

Tujuan dari penelitian ini adalah : (1) Untuk mengetahui Bagaimana Strategi Guru Pendidikan Agama Islam dalam meningkatkan kecerdasan spiritual peserta didik di SMAN 5 Kota Kupang (2) untuk mengetahui faktor pendukung dan penghambat Guru Pendidikan Agama Islam dalam meningkatkan kecerdasan spiritual peserta didik di SMAN 5 Kota Kupang.
Pendekatan penelitian yang digunakan dalam penelitian ini adalah pendekatan kualitatif.
Hasil penelitian adalah (1) strategi yang digunakan Guru Pendidikan Agama Islam dalam meningkatkan kecerdasan spiritual peserta didik yaitu dengan memberikan pembiasaan-pembiasaan keagamaan sebelum memulai proses pembelajaran. Seperti : melaksanakan sholat dhuha, membaca Al-Quran dan juga mengikutsertakan peserta didik di berbagai kegiatan-kegiatan keagamaan agar meningkatkan kecerdasan spiritulanya. Bukan hanya itu Guru Pendidikan Agama Islam Juga menanamkan nilai-nilai spiritual dengan memberikan motivasi-motivasi terhadap peserta didik. (2) Faktor-faktor yang mendukung penerapan strategi Guru Pendidikan Agama Islam dalam meningkatkan kecerdasan spiritual peserta didik yaitu : Peran kepala sekolah, Peran orang tua dan Peran Guru-guru agama islam. Namun faktor penghambatnya antara lain sebagai berikut: Beberapa siswa yang belum memahami ajaran agama, jumlah guru dengan siswanya tidak proporsional dan sarana prasarana yang tidak memadai.
Dinamika Makanan Tradisional Bombo Latung
Authors: Balun Marselinus , Aryanto Bessie Polce 
Published: August 2024

Bombo latung berbahan dasar jagung yang di tumbuk. Makanan tradisional Bombo latung biasanya orang dulu disajikan sebagai makanan utama sebelum melakukan aktivias karena orang dulu beras hanya dimiliki oleh orang kaya. Bombo latung bisa di jadikan sebagai bekal anak sekolah pada zaman dulu, dalam bahasa Manggarainya yaitu “Bokong de anak sekola” Bokong di artikan sebagai bekal. Konsep yang digunakan yaitu dinamika dan makanan tradisional bombo latung. Metode yang dipakai dalam penelitian ini yaiu kualitatif dengan model penelitian etnografi melalui teknik observasi, wawancara dan dokumentasi. Makanan tradisionl Bombo latung mengalami dinamika diakibatkan oleh beberapa faktor seperti parawisata, ekonomi dan budaya. Meskipun demikian makanan tradisional Bombo latung ini masih dijaga kelestariannya oleh hotel Meruorah Komodo Labuan Bajo. Selain makanan tradisional Bombo latung bersifat budaya, makanan tradisional ini disajikan secara terbuka. Makanan tradisional Bombo latung secara terbuka disajikan kepada para wisatawan yang datang menginap maupun hanya sekedar berkunjung ke Meruorah Komodo Labuan Bajo
Pengaruh Model SSCS Berbasis Pendekatan Lingkungan Terhadap Keterampilan Proses Sains Siswa SD IT Al-Ishlah Sudimampir
Authors: Sari Siti Komala , Dewi Ririn Andriani Kumala , Khoimatun Khoimatun 
Published: August 2024

Keterampilan proses sains siswa dalam proses pembelajaran masih kurang terlatih, penggunaan model pembelajaran yang jarang dilakukan menjadi faktor kurangnya minat dan terstimulusnya keterampilan proses sains siswa dalam belajar, oleh karena itu sudah dilakukan penelitian yang bertujuan untuk mengetahui peningkatan dan pengaruh model SSCS berbasis pendekatan lingkungan terhadap keterampilan proses sains pada materi manfaat makhluk hidup bagi lingkungan sekitar di SD IT Al-Ishlah Sudimampir. Penelitian ini bertujuan untuk mengetahui apakah ada peningkatan atau pengaruh terhadap model pembelajaran SSCS berbasis pendekatan lingkungan terhadap keterampilan proses sains. Penelitian ini merupakan penelitian eksperimen dengan desain Pretest dan Postest Control Group Design. Populasi penelitian ini seluruh siswa kelas IV SD IT Al-Ishlah Sudimampir Tahun Pelajaran 2021/2022. Dengan menggunakan teknik random sampling ditetapkan kelas IV A sebagai kelas eksperimen dengan jumlah 22 siswa dan kelas IV B sebagai kelas kontrol dengan jumlah 21 siswa. data penelitian dikumpulkan melalui tes tulis. Berdasarkan hasil uji hipotesis dengan menggunakan independent samples t-tes, diperoleh data Sig<a, yaitu 0,000 < 0,05 sehingga Ho ditolak dan Ha diterima. Hal ini menunjukkan bahwa terdapat pengaruh model pembelajaran SSCS berbasis pendekatan lingkungan terhadap keterampilan proses sains siswa kelas IV terbukti bahwa respon siswa meningkat setelah menggunakan model pembelajaran SSCS berbasis pendekatan lingkungan. Penelitian ini diharapkan mampu memberikan khazanah baru dalam keilmuan, serta memmberikan manfaat kepada para pembaca terutama dalam pemilihan media yang cocok dalam proses pembelajaran.
Upaya Meningkatkan Kemampuan Membaca Pemahaman pada Mata Pelajaran Bahasa Indonesia Menggunakan Media Big Book Kelas III MI Miftahul Ulum II Kecamatan Karangampel Kabupaten Indramayu
Authors: Hodijah Hodijah , Wardani Wawan Setia , Wilsa Asrizal Wahdan 
Published: August 2024

Kegiatan membaca memegang peranan penting dalam kehidupan terutama dalam pendidikan. Dunia pendidikan tidak lepas dari kegiatan membaca. Untuk menindentifikasi masalah – masalah yang ada dalam penelitian ini , permasalahan masih rendahnya kemampuan ,minat dan memahami teks bacaan, guru belum menggunakan media yang menarik, siswa masih kurang lancar dan memahami teks bacaan. Tujuan mengetahui penerapan penggunaan media Big Book untuk meningkatkan kemampuan membaca pemahaman, mengetahui apakah media Big Book dapat meningkatkan hasil belajar siswa kelas III MI Miftahul Ulum II Karangampel Indramayu. Penelitian ini menggunakan metode penelian PTK desain kemmis dan mc taggart. Instrument penelitian yang digunakan adalah observasi proses menggunakan media Big Book dan soal tes untuk mengetahui kemampuan membaca pemahaman siswa. Pada siklus I mendapatkan hasil persentase dari proses pembelajaran menggunakan media Big Book sebesar 69,37% dan pada siklus II mendapatkan hasil sebesar 84,37%. Pada kemampuan membaca pemahaman siswa ada siklus I mendapatkan persentase 67% dan pada siklus II mendapatkan persentase sebesar 81%. Pencapaian ini telah melebihi indicator keberhasilan yang telah ditentukan yaitu 75%.
Audit of the Financial Audit Agency on the Procurement of Goods and Services Reviewed from the Corruption Eradication Commission (Case Study of Land Acquisition Owned by the Sumber Waras Health Foundation by the Regional Government of DKI Jakarta Province
Authors: Fatimah Siti , Sulaiman Abdullah , Hidayati Hidayati 
Published: August 2024

The report on the results of the investigation by the Jakarta Provincial Government's Financial Audit Agency in 2014 explained that there were irregularities in the purchase of 36,410 square meters of land belonging to the Sumber Waras Health Foundation by the Jakarta Provincial Government. The purpose of this study is to understand the indications of state financial irregularities or according to the rules when reviewed from the Corruption Eradication Commission. The method uses a normative juridical approach, using literature or secondary data as the basis for research, and is carried out by looking for regulations and literature related to the problem being studied. The results explained that the Financial Audit Agency claimed that the purchase of land for the Sumber Waras Health Foundation was found to have the potential to harm the state reaching Rp191 billion, which was reported during a hearing at Commission three of the House of Representatives of the Republic of Indonesia with the Corruption Eradication Commission on June 14, 2016. Based on Law 30 of 2002 concerning the Corruption Eradication Commission which has conducted an investigation, two crucial numbers are explained, including: first, the investigators of the Corruption Eradication Commission stated that they did not find any unlawful acts in the purchase of land for the Sumber Waras Health Foundation; Second, the Corruption Eradication Commission invited experts, including the Indonesian Appraiser Professional Association. According to the results reported by the Financial Audit Agency regarding the finances of the DKI Jakarta Provincial Government in 2014 and the investigation from the Audit of the Financial Audit Agency, there were six irregularities including planning, budgeting, team formation, procurement, price formation, and delivery of results. As a result, the state's financial losses amounted to Rp191 billion.
Challenges and Opportunities for Women Entrepreneurs of Supply Chain Businesses in Pakistan
Authors: Fayyaz Benish , Sheikh Sanaa Hafeez , Taj Ayman , Lakho Asadullah 
Published: August 2024

The purpose of this paper is to look into the challenges women business owners in Pakistan confront, the opportunities available to them, and how social media can improve their knowledge and business skills while also promoting women's empowerment. Qualitative methodology was used for this exploratory research using phenomenological approach. Result of this study have been broadly categorized into eight major themes that contribute to women entrepreneurs success including Socio-Economic Factor, Family support, Entrepreneur’s skills, Well-being & Work life balance, Dynamic Environment, Utility of social media, Entrepreneurial support & education and E-Commerce. The present study shows the challenges and opportunities for women entrepreneurship in supply chain dynamics is multi-dimensional and they are related to all these factors. Since this study is one of early ones to consider exploring the challenges and opportunities of women entrepreneurs in Pakistan and provides a deeper understanding on the subject so, it has practical implications for dealing with the social issue especially in the local context of Pakistan. The results of this study can be used by numerous organizations to create learning & growth materials, improving the lives of female entrepreneurs. The study has also suggested the need for further research on the subject, as in addition to qualitative, quantitative studies can be conducted. By using the research study as a foundation and building it in quantitative research, there are many opportunities for expanding the research.
La forma de la pena: aproximaci´on fenomenol´ogica de la pérdida
Authors: Videla Reyes Ronnie , González Durán Néstor 
Published: August 2024

El presente estudio busca describir fenomenológicamente la forma que exhibe la pena en el cuerpo, después de la pérdida de un ser querido. Para esto, se consideran las hipótesis de movimiento centrípeto orientado a la autoafección, y movimiento centrífugo aludido a la ruptura de la intercorpereidad. Ambos movimientos, hacen referencia a la sensación ambigua que el cuerpo vive en la pena asociados a la presencia y ausencia del otro que ya no está, ya que el dolor provee un estado de desincronización temporal que vuelve simultáneos el presente-pasado y presente-futuro. Esto trae como consecuencias, la contracción y extensión del cuerpo a partir de la maleabilidad de sus propios límites.
Maternal smoking DNA methylation risk score associated with health outcomes in offspring of European and South Asian ancestry
Authors: Deng Wei Q , Cawte Nathan , Campbell Natalie , Azab Sandi M , de Souza Russell J , Lamri Amel , Morrison Katherine M , Atkinson Stephanie A , Subbarao Padmaja , Turvey Stuart E , Moraes Theo J , Teo Koon K , Mandhane Piush J , Azad Meghan B , Simons Elinor , Paré Guillaume , Anand Sonia S 
Published: August 2024

Background:Maternal smoking has been linked to adverse health outcomes in newborns but the extent to which it impacts newborn health has not been quantified through an aggregated cord blood DNA methylation (DNAm) score. Here, we examine the feasibility of using cord blood DNAm scores leveraging large external studies as discovery samples to capture the epigenetic signature of maternal smoking and its influence on newborns in White European and South Asian populations.Methods:We first examined the association between individual CpGs and cigarette smoking during pregnancy, and smoking exposure in two White European birth cohorts (n=744). Leveraging established CpGs for maternal smoking, we constructed a cord blood epigenetic score of maternal smoking that was validated in one of the European-origin cohorts (n=347). This score was then tested for association with smoking status, secondary smoking exposure during pregnancy, and health outcomes in offspring measured after birth in an independent White European (n=397) and a South Asian birth cohort (n=504).Results:Several previously reported genes for maternal smoking were supported, with the strongest and most consistent association signal from the GFI1 gene (6 CpGs with p<5 × 10-5). The epigenetic maternal smoking score was strongly associated with smoking status during pregnancy (OR = 1.09 [1.07, 1.10], p=5.5 × 10-33) and more hours of self-reported smoking exposure per week (1.93 [1.27, 2.58], p=7.8 × 10-9) in White Europeans. However, it was not associated with self-reported exposure (p>0.05) among South Asians, likely due to a lack of smoking in this group. The same score was consistently associated with a smaller birth size (–0.37±0.12 cm, p=0.0023) in the South Asian cohort and a lower birth weight (–0.043±0.013 kg, p=0.0011) in the combined cohorts.Conclusions:This cord blood epigenetic score can help identify babies exposed to maternal smoking and assess its long-term impact on growth. Notably, these results indicate a consistent association between the DNAm signature of maternal smoking and a small body size and low birth weight in newborns, in both White European mothers who exhibited some amount of smoking and in South Asian mothers who themselves were not active smokers.Funding:This study was funded by the Canadian Institutes of Health Research Metabolomics Team Grant: MWG-146332.
PCSK9 inhibitor effectively alleviated cognitive dysfunction in a type 2 diabetes mellitus rat model
Authors: Yang Yang , Wang Yeying , Wang Yuwen , Ke Tingyu , Zhao Ling 
Published: August 2024

Background
The incidence of diabetes-associated cognitive dysfunction (DACD) is increasing; however, few clinical intervention measures are available for the prevention and treatment of this disease. Research has shown that proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors, particularly SBC-115076, have a protective effect against various neurodegenerative diseases. However, their role in DACD remains unknown. In this study, we aimed to explore the impact of PCSK9 inhibitors on DACD.

Methods
Male Sprague-Dawley (SD) rats were used to establish an animal model of type 2 diabetes mellitus (T2DM). The rats were randomly divided into three groups: the Control group (Control, healthy rats, n = 8), the Model group (Model, rats with T2DM, n = 8), and the PCSK9 inhibitor-treated group (Treat, T2DM rats treated with PCSK9 inhibitors, n = 8). To assess the spatial learning and memory of the rats in each group, the Morris water maze (MWM) test was conducted. Hematoxylin-eosin staining and Nissl staining procedures were performed to assess the structural characteristics and functional status of the neurons of rats from each group. Transmission electron microscopy was used to examine the morphology and structure of the hippocampal neurons. Determine serum PCSK9 and lipid metabolism indicators in each group of rats. Use qRT-PCR to detect the expression levels of interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α) in the hippocampal tissues of each group of rats. Western blot was used to detect the expression of PCSK9 and low-density lipoprotein receptor (LDLR) in the hippocampal tissues of rats. In addition, a 4D label-free quantitative proteomics approach was used to analyse protein expression in rat hippocampal tissues. The expression of selected proteins in hippocampal tissues was verified by parallel reaction monitoring (PRM) and immunohistochemistry (IHC).

Results
The results showed that the PCSK9 inhibitor alleviated cognitive dysfunction in T2DM rats. PCSK9 inhibitors can reduce PCSK9, total cholesterol (TC), and low-density lipoprotein (LDL) levels in the serum of T2DM rats. Meanwhile, it was found that PCSK9 inhibitors can reduce the expression of PCSK9, IL-1β, IL-6, and TNF-α in the hippocampal tissues of T2DM rats, while increasing the expression of LDLR. Thirteen potential target proteins for the action of PCSK9 inhibitors on DACD rats were identified. PRM and IHC revealed that PCSK9 inhibitors effectively counteracted the downregulation of transthyretin in DACD rats.

Conclusion
This study uncovered the target proteins and specific mechanisms of PCSK9 inhibitors in DACD, providing an experimental basis for the clinical application of PCSK9 inhibitors for the potential treatment of DACD.
The Reproductive Biology of Auchenoglanis biscutatus and Protopterus annectens from Lower River Benue Wadata, Makurdi-Nigeria
Authors: T.M Igbana , P.A. Annune , R.A. Obande, , T. Gbaaondo, 
Published: August 2024

Data on the reproductive biology of Auchenoglanis biscutatus and Protopterus annectens were collected between april 2019 to march 2020. Reproductive parameters including sex ratio was determined as number of males by number of females, gonadosomatic index as total gonad weight by body weight and expressed in percentage while fecundity was obtained via volumetric and gravimetric methods. There was a slight dominance of males over females of both species (1.1:1) with more immature individuals caught within the study period. Higher GSI, gonad length and gonad weight (0.87±0.06, 15.94±0.89 and 3.01±0.19) were recorded in Auchenoglanis biscutatus during dry season while GSI and gonad weight (4.06±0.62, 5.63±0.45) of Protopterus annectens and number of mature fishes (0.35) were higher during rainy season. The relative fecundity for Auchenoglanis biscutatus investigated had no significant difference in both seasons (7.99±0.94, 8.22±0.78) while the relative fecundity for Protopterus annectentens differed significantly among the wet and dry seasons (3.43±0.94, 0.48±0.22). The relative fecundity of Protopterus annectens (11.59±2.04) was higher than that of Auchenoglanis biscutatus (8.04±0.75).it was concluded that the study of the sex ratio indicates that males were higher than females.
The 100 Most Cited Articles on Glass Ionomer Cement: A Bibliometric Analysis
Authors: Torres Adriana da Silva , Martins Olga Beatriz Lopez , Mendes Brauller Dias , Melo Callebe Carneiro de , Silva Breno Campos da , Torres Moisés de Matos , Araújo Cíntia Tereza Pimenta de 
Published: August 2024

Aims: This bibliometric review aimed to rank, examine, and present the 100 most cited publications in the literature on glass ionomer cement, in order to evaluate the progress of scientific production and thus contribute to future studies.
Study Design: Bibliometric review.
Methodology: A search using MESH terms was performed in the Clarivate Analytics Web of Science database. Two independent authors selected the 100 most cited articles. There were no restrictions regarding the study design, year of publication, language or journal impact factor of the manuscripts. The year of publication, authors, citation count, periodicals, keywords, contributing institution, country, among other details, were extracted from the articles included.
Results: The initial search identified 5,186 articles. Among the 100 most cited articles selected, the author with the highest number of publications was Frencken JE. The most cited article, by Wiegand A et al. in 2007, had a total of 547 citations. The oldest manuscript was published in 1977 by Forsten L. The University of Manchester and Medical College of Georgia led the list of institutions. The country with the highest number of publications was the USA. The top journals were Dental Materials leading the ranking, followed by the Journal of Dental Research and the Journal of Prosthetic Dentistry. The most used keywords in this list were: fluoride release, glass-ionomer cements, glass-ionomer cement. The years with the highest concentration of publications were between 1998 and 2003.
Conclusion: This analysis reinforces the importance of periodic reviews and updates in the literature, promoting the dissemination of knowledge and the continuous advancement in dental materials science.
The activity and radial dependence of anomalous diffusion by pitch angle scattering on split magnetic drift shells
Authors: O'Brien T. P. 
Published: December 2014

AbstractAsymmetries in the magnetospheric magnetic field produce drift shell splitting, which causes the radial (drift shell) invariant to sometimes depend on pitch angle. Where drift shell splitting is significant, pitch angle scattering leads to diffusion in all three invariants of the particle's motion, including cross diffusion. We examine the magnitude of drift shell splitting‐related anomalous diffusion for outer zone electrons compared to conventional diffusion in the absence of drift shell splitting. We assume that the primary local scattering process is wave‐particle interactions with chorus. We find that anomalous radial diffusion can exceed that of conventional drift‐resonant radial diffusion for particles with energies near 0.1 MeV at all radial distances outside the plasmasphere during quiet to moderate geomagnetic activity, and it is significant at 0.5 MeV. Cross diffusion involving the radial invariant can exceed the geometric mean of the corresponding pure diffusion coefficients at 0.1 MeV, and that such cross diffusion is significant even at 0.5–1 MeV. At 1 MeV, cross diffusion is often significant. The highest radial distances and magnetic activity levels in our study do not always exhibit as much significant anomalous diffusion as moderate radial distances and activity levels. This can be explained by (a) stronger dependence of conventional diffusion on magnetic activity and radius, and (b) strongest drift shell splitting at moderate magnetic activity. Simulation codes that neglect the possibility for cross terms will likely systematically underperform, especially for 0.1–0.5 MeV electrons, for much of the outer zone for quiet to moderate levels of magnetic activity.