bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mycoplasma Hyorhinis Infection Promotes NF-κB–Dependent Migration of Gastric Cancer Cells
Authors: Duan Hongying , Chen Ling , Qu Like , Yang Hua , Song Sonya Wei , Han Yong , Ye Meihua , Chen Wanyuan , He Xianglei , Shou Chengchao 
Published: August 2014

Abstract
Chronic infection of Mycoplasma hyorhinis (M. hyorhinis) has been postulated to be associated with several types of cancer, but its effect on patients' survival and host factors mediating its infection remain unclear. Herein, we demonstrated that M. hyorhinis p37 protein expression in gastric cancer tissues predicts poor survival and associates with metastasis. M. hyorhinis infects mammalian cells and promotes gastric cancer cell invasiveness via its membrane protein p37. Synthesized peptide corresponding to the N-terminus of p37 prevents M. hyorhinis infection. Host Annexin A2 (ANXA2) interacts with the N-terminus of p37. In addition, EGFR forms a complex with p37 and ANXA2, and is required for M. hyorhinis–induced phosphorylation and membrane recruitment of ANXA2. M. hyorhinis infection is inhibited by siRNA-mediated knockdown of ANXA2 or EGFR, but is enhanced by expression of ectopic ANXA2 or EGFR. Downstream of ANXA2 and EGFR, the NF-κB pathway is activated and mediates M. hyorhinis–driven cell migration. In conclusion, our study unveils the effect of M. hyorhinis infection on gastric cancer survival and uncovers the mechanisms by which M. hyorhinis infects mammalian cells and promotes cancer cell migration. Cancer Res; 74(20); 5782–94. ©2014 AACR.
PRMT7 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Breast Cancer
Authors: Yao Ruosi , Jiang Hao , Ma Yuhui , Wang Liping , Wang Lin , Du Juan , Hou Pingfu , Gao Yanyan , Zhao Li , Wang Guannan , Zhang Yu , Liu Dong-Xu , Huang Baiqu , Lu Jun 
Published: August 2014

Abstract
Epithelial-to-mesenchymal transition (EMT) enables metastasis. E-cadherin loss is a hallmark of EMT, but there remains an incomplete understanding of the epigenetics of this process. The protein arginine methyltransferase PRMT7 functions in various physiologic processes, including mRNA splicing, DNA repair, and neural differentiation, but its possible roles in cancer and metastasis have not been explored. In this report, we show that PRMT7 is expressed at higher levels in breast carcinoma cells and that elevated PRMT7 mediates EMT and metastasis. PRMT7 could inhibit the expression of E-cadherin by binding to its proximal promoter in a manner associated with altered histone methylation, specifically with elevated H4R3me2s and reduced H3K4me3, H3Ac, and H4Ac, which occurred at the E-cadherin promoter upon EMT induction. Moreover, PRMT7 interacted with YY1 and HDAC3 and was essential to link these proteins to the E-cadherin promoter. Silencing PRMT7 restored E-cadherin expression by repressing H4R3me2s and by increasing H3K4me3 and H4Ac, attenuating cell migration and invasion in MDA-MB-231 breast cancer cells. Overall, our results define PRMT7 as an inducer of breast cancer metastasis and present the opportunity for applying PRMT7-targeted therapeutics to treat highly invasive breast cancers. Cancer Res; 74(19); 5656–67. ©2014 AACR.
Mortality Reduction in Relation to Implantable Cardioverter Defibrillator Programming in the Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT)
Authors: Ruwald Anne-Christine , Schuger Claudio , Moss Arthur J. , Kutyifa Valentina , Olshansky Brian , Greenberg Henry , Cannom David S. , Estes N.A. Mark , Ruwald Martin H. , Huang David T. , Klein Helmut , McNitt Scott , Beck Christopher A. , Goldstein Robert , Brown Mary W. , Kautzner Josef , Shoda Morio , Wilber David , Zareba Wojciech , Daubert James P. 
Published: August 2014

Background—
The benefit of novel implantable cardioverter defibrillator (ICD) programming in reducing inappropriate ICD therapy and mortality was demonstrated in Multicenter Automatic Defibrillator Implantation Trial-Reduce Inappropriate Therapy (MADIT-RIT). However, the cause of mortality reduction remains incompletely evaluated. We aimed to identify factors associated with mortality, with focus on ICD therapy and programming in the MADIT-RIT population.

Methods and Results—

In MADIT-RIT, 1500 patients with a primary prophylactic indication for ICD or cardiac resynchronization therapy with defibrillator were randomized to 1 of 3 different ICD programming arms: conventional programming (ventricular tachycardia zone ≥170 beats per minute), high-rate programming (ventricular tachycardia zone ≥200 beats per minute), and delayed programming (60-second delay before therapy ≥170 beats per minute). Multivariate Cox models were used to assess the influence of time-dependent appropriate and inappropriate ICD therapy (shock and antitachycardia pacing) and randomized programming arm on all-cause mortality. During an average follow-up of 1.4±0.6 years, 71 of 1500 (5%) patients died: cardiac in 40 patients (56.3%), noncardiac in 23 patients (32.4%), and unknown in 8 patients (11.3%). Appropriate shocks (hazard ratio, 6.32; 95% confidence interval, 3.13–12.75;
P
<0.001) and inappropriate therapy (hazard ratio, 2.61; 95% confidence interval, 1.28–5.31;
P
=0.01) were significantly associated with an increased mortality risk. There was no evidence of increased mortality risk in patients who experienced appropriate antitachycardia pacing only (hazard ratio, 1.02; 95% confidence interval, 0.36–2.88;
P
=0.98). Randomization to conventional programming was identified as an independent predictor of death when compared with patients randomized to high-rate programming (hazard ratio, 2.0; 95% confidence interval, 1.06–3.71;
P
=0.03).

Conclusions—
In MADIT-RIT, appropriate shocks, inappropriate ICD therapy, and randomization to conventional ICD programming were independently associated with an increased mortality risk. Appropriate antitachycardia pacing was not related to an adverse outcome.

Clinical Trial Registration—

URL:
clinicaltrials.gov
Unique identifier: NCT00947310.
Aging of the Nitric Oxide System: Are We as Old as Our NO?
Authors: Sverdlov Aaron L. , Ngo Doan T.M. , Chan Wai P.A. , Chirkov Yuliy Y. , Horowitz John D. 
Published: August 2014

Background

Impaired generation and signaling of nitric oxide (
NO)
contribute substantially to cardiovascular (
CV
) risk (
CVR
) associated with hypertension, hyperlipidemia, and diabetes mellitus. In our rapidly aging society, advanced age is, in itself, a consistent and independent
CVR
factor. Many processes involved in aging are modulated by
NO
. We therefore postulated that aging might be independently associated with impaired
NO
signaling.

Methods and Results

In a prospective cohort study of 204 subjects (mean age 63±6 at study entry), we evaluated the effects of 4 years of aging on parameters of
NO
generation and effect, including platelet aggregability and responsiveness to
NO
, and plasma concentrations of the
NO
synthase inhibitor, asymmetric dimethylarginine (
ADMA
). Clinical history, lipid profile, high‐sensitivity C‐reactive protein, routine biochemistry, and 25‐hydroxyvitamin D levels were obtained at study entry and after 4 years of follow‐up. Aging was associated with marked deterioration of responsiveness of platelets to
NO
(
P
<0.0001) and increases in plasma
ADMA
concentrations (
P
<0.0001). There was a significant correlation between changes in these parameters over time (
r
=0.2;
P
=0.013). On multivariable analyses, the independent correlates of deterioration of responsiveness of platelets to
NO
were female gender (β=0.17;
P
=0.034) and low vitamin D concentrations (β=0.16;
P
=0.04), whereas increases in
ADMA
were associated with presence of diabetes (β=0.16;
P
=0.03) and impaired renal function (β=0.2;
P
=0.004).

Conclusions

Aging is associated with marked impairment of determinants of
NO
generation and effect, to an extent which is commensurate with adverse impact on
CV
outcomes. This deterioration represents a potential target for therapeutic interventions.
KuROS: A New Airborne Ku-Band Doppler Radar for Observation of Surfaces
Authors: Caudal Gérard , Hauser Danièle , Valentin René , Le Gac Christophe 
Published: August 2014

Abstract
This study presents the new airborne Doppler radar Ku-Band Radar for Observation of Surfaces (KuROS), which provides measurements of the normalized radar cross section σ° and of the Doppler velocity over the sea. The system includes two antennas rotating around a vertical axis, although only the results from the lower incidence (14°) antenna are presented here. Also given are the first results from observations performed during two field campaigns held in 2013: the Hydrological Cycle in Mediterranean Experiment (HyMeX) and the Prévision Océanique, Turbidité, Ecoulements, Vagues et Sédimentologie (PROTEVS).
Sea wave directional spectra computed by the radar from tilt modulation of σ° are consistent with those given by the directional wave rider moored in the Mediterranean basin, both in terms of significant wave height Hs and main features of the wavenumber spectrum. As concerns the azimuthal distribution, two methods are tested to remove the 180° ambiguity of the radar-derived directional spectrum. The first method is based on the correlation between the modulations of σ° and Doppler velocity, which reflects the correlation between the sea surface slope and orbital velocity. The second method does not use the Doppler velocity but computes the cross spectrum between the modulations of σ° between two power profiles separated by some time lag ΔT, from which the phase velocity of sea waves is deduced. Comparing the sea wave directional spectra disambiguated by both methods, with the directional spectrum given by the wave rider, it is concluded that the first method (using Doppler velocity) is more efficient to remove the 180° ambiguity and should be preferred to the second method.
Head and Neck Sarcomas: Analysis of the SEER Database
Authors: Peng Kevin A. , Grogan Tristan , Wang Marilene B. 
Published: August 2014

ObjectiveTo summarize the epidemiology of sarcomas occurring in the head and neck and identify prognostic factors for patient survival.Study Design and SettingCross‐sectional analysis of the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) program.MethodsThe SEER 18 registries, comprising sarcoma diagnoses made from 1973 to 2010, were queried for sarcomas arising in the head and neck. Pediatric and adult patients were analyzed separately, and multivariate and propensity‐matched analyses were performed to identify predictors of disease‐specific survival.ResultsIn all, 11,481 adult cases and 1244 pediatric cases were identified. In adults, the most common histologic subtypes were malignant fibrous histiocytoma (MFH), Kaposi sarcoma, and hemangiosarcoma, while in the pediatric cohort, the most common histologic subtypes were rhabdomyosarcoma, MFH, and osteosarcoma. Cause‐specific 2‐, 5‐, and 10‐year survival rates were 76%, 66%, and 61% for adults and 84%, 73%, and 71% for pediatric patients. Multivariate analysis performed for adults revealed that male gender, absence of radiation therapy, and stage I disease were associated with improved cause‐specific survival reaching statistical significance. However, a propensity‐matched model demonstrated no significant difference in cause‐specific survival between patients who received radiation and those who did not.ConclusionSarcomas, a heterogeneous group of malignant mesenchymal tumors, are uncommonly found in the head and neck. This study represents the largest analysis of patients with head and neck sarcomas in the literature and demonstrates the impact of age, gender, primary site, histology, and radiation status on overall prognosis.
Central versus peripheral arterial cannulation and neurological outcomes after thoracic aortic surgery: meta-analysis and meta-regression of 4459 patients
Authors: Chalegre ST , Sá MPBO , de Rueda F Gonçalves , Salerno PR , Vasconcelos FP , Lima RC 
Published: August 2014

Background: Thoracic aortic surgeries remain with high mortality rates, often associated with postoperative neurological complications. The choice of the right cannulation site is extremely important for suitable blood supply and maintenance of vital functions, especially of the central nervous system. Objectives: To compare the influence of central versus peripheral arterial cannulation on neurological outcomes in patients undergoing thoracic aortic surgery through systematic review and meta-analysis. Methods: MEDLINE, EMBASE, CENTRAL/CCTR, SciELO, LILACS and reference lists of relevant articles were searched for clinical studies that reported in-hospital neurological outcomes after central or peripheral arterial cannulation during thoracic aortic surgery procedures until December 2013. The principal summary measures were Odds Ratio (OR) for central compared to peripheral arterial cannulation with 95% confidence interval (CI) and p-values considered statistically significant when <0.05. The ORs were combined across studies, using the DerSimonian-Laird random effects model and fixed effects model using the Mantel-Haenszel model - both models were weighted. The meta-analysis was completed using the software Comprehensive Meta-Analysis version 2 (Biostat Inc., Englewood, NJ). Results: Six studies were identified and included a total of 4459 patients (1180 for central and 3279 for peripheral cannulation). There was no significant difference between the central and peripheral groups regarding neurological outcomes. The meta-regression evidenced no relationship between neurological outcomes and the variables age, sex, previous coronary event, previous neurological event, urgency surgery, cardiopulmonary bypass time, activated clotting time and esophageal temperature with p>0,05. Conclusion: When it comes to neurological outcomes in patients undergoing thoracic aortic surgery, there was no evidence that argues in favor of any choice of arterial cannulation site, which makes us reject any superiority of one approach over the other in this regard.
Herpes zoster ophthalmicus following onabotulinumtoxinA administration for chronic migraine: A case report and literature review
Authors: Gadient Paul M , Smith Jonathan H , Ryan Stephen J 
Published: August 2014

Background There is a growing body of literature documenting local herpes zoster outbreak following procedures. The mechanism underlying these outbreaks remains elusive. We present a case of zoster following onabotulinumtoxinA (BTX) for migraine and a literature review. Methods Chart and literature review. Case A 72-year-old woman with chronic migraine received BTX injections for 3 years without incident. She had a history of thoracic zoster with subsequent post-herpetic neuralgia. In August 2013, 48 hours after receiving BTX injections, she developed a painful rash in the right V1 distribution consistent with herpes zoster ophthalmicus. One week later the rash had resolved without treatment. Literature review We identified 65 (including 2 from Juel-Jenson) cases of zoster reactivation following minor procedures. These cases tend to be in young patients without specific risk factors. Outbreaks characteristically occur at the level of exposure to local trauma. Discussion Our review suggests that local trauma, regardless of the nature of stimuli, may be sufficient for zoster reactivation. We hypothesize that the stressors in these reported cases exert a local epigenetic influence on viral transcription, allowing for viral reactivation. Conclusion Zoster is a potential complication of BTX administration for chronic migraine in adults. Physician awareness can reduce the significant morbidity associated with this disease.
Foulkes’ Roots in Trigant Burrow’s Writings
Authors: Pertegato Edi Gatti 
Published: August 2014

Given the subject of the present workshop, a few hints on the ‘development in intersubjectivity’ in group analysis will show that from psychoanalysis to group analysis Trigant Burrow’s work has focused on intersubjectivity since its inception, forestalling the ‘so called’ intersubjective schools in psychoanalysis. Brief historical notes on psychoanalysis and group analysis are presented to show how historical reports, more or less unconsciously, may be affected by ungrounded accounts which, through transpersonal and transgenerational processes, may be perpetuated to the detriment of knowledge and of its advance. Finally, through the presentation of Burrow’s main group analytic concepts and methods, the burning issue of the roots of group analysis are discussed, which are unquestionably in Burrow’s writings.
Dosing and effectiveness of ketamine anesthesia for electroconvulsive therapy (ECT): a case series
Authors: Bryson Ethan O , Ahle Gabriella M , Liebman Lauren S , Aloysi Amy S , Majeske Matthew F , Lapidus Kyle A , Kellner Charles H 
Published: August 2014

Objective: To provide additional data about the clinical efficacy and dosing range for ketamine used as the induction agent in electroconvulsive therapy (ECT). Method: We reviewed the clinical data in our academic hospital ECT service over the last four years for patients who had received ketamine as the sole, or adjunctive, anesthesia induction agent. We extracted clinical data about antidepressant response as well as absolute and weight-based dosing for ketamine. Results: We found nine patients who were treated with ketamine as the anesthetic at some point during the course of their treatment (eight as the sole agent, one as adjunctive). The median induction dose for ketamine was 1.1 mg/kg. For most patients, there was demonstrable clinical benefit. Conclusions: Ketamine has a role as an alternative induction anesthetic agent in ECT. Our case series adds to the literature on the concomitant use of ECT and ketamine.
Acquisition of Russian gender agreement by monolingual and bilingual children
Authors: Schwartz Mila , Minkov Miriam , Dieser Elena , Protassova Ekaterina , Moin Victor , Polinsky Maria 
Published: August 2014

Aim and Objectives/Purpose/Research Questions: The main goal of this study was to examine noun–adjective gender agreement in Russian by comparing bilingual children with diverse L2 backgrounds (English, Finnish, German, and Hebrew) with age-matched monolingual children and monolinguals one year younger. This comparison was made to investigate the influence of L2 grammar on the acquisition of gender agreement by (L1) Russian-speaking children. Design/Methodology/Approach: The participants included four groups of 4–5-year-old bilingual children with Russian as L1 and English, German, Finnish, or Hebrew as L2, who were compared to monolingual children in Russia in two age groups (3–4 and 4–5 years old). The children were matched by socioeconomic status and parents’ educational background. All children were tested individually during one testing session. Agreement data were elicited using a semi-structured elicitation test, with verbal and visual stimuli. Data and Analysis: We used qualitative data analysis to identify types and categories of errors, and quantitative data analysis to compare the tendencies of noun–adjective gender agreement in Russian (L1) between the groups. Findings/Conclusions: Development of gender agreement in the bilingual children from different L2 backgrounds was qualitatively similar to that of the 3–4-year-old monolingual Russian-speaking children. This result suggests that bilingual development in L1 follows the same developmental path as monolingual development, albeit with a delay. In addition, bilingual children whose L2 has grammatical gender (German, Hebrew) outperformed the other bilinguals on gender agreement, indicating that the presence of a grammatical category in both languages spoken by a bilingual facilitates category acquisition. Originality and Significance/Implications: The study contributes to the discussion on how the transparency and phonological saliency might affect the bilingual children’s acquisition of inflectional morphology and on how influence of L2 on L1 might in some cases help and in other cases impede the acquisition of L1.
Open versus endovascular repair of abdominal aortic aneurysm: Incidence of cardiovascular events in 632 patients in a department of defense cohort over 6-year follow-up
Authors: Thomas Dustin , Anderson David , Hulten Edward , McRae Fiora , Ellis Shane , Malik Jamil A , Villines Todd C , Slim Ahmad M 
Published: August 2014

Background Abdominal aortic aneurysm (AAA) is common with unacceptably high rates of mortality and morbidity with unknown rates of complications after repair in the Department of Defense (DoD). Methods All patients treated at a DOD or VA clinic or medical facility with a diagnosis of AAA identified by ICD-9 code search were identified by Patient Administration Systems and Biostatistics Activity (PASBA) using the Standard Inpatient Data Record (SIDR) and Composite Ambulatory Patient Encounter Record (CAPER) from January 2006 till December 2011. The primary outcome was death, myocardial infarction (MI), stroke, and cardiac arrhythmia between subjects who underwent endovascular aortic repair (EVAR) or open aortic repair (OAR). Results A total of 8314 patients were screened to identify 632 patients who underwent surgical repair of non-ruptured AAA. EVAR was performed in 497 patients (78.6%) and OAR in 135 patients (21.4%). Mortality at 30 days was less common in EVAR patients (1.6% vs. 6.7%, p = 0.004), but was not sustained (16.9% vs. 17.8%, p = 0.797). Mean survival free from mortality was not different between the two groups (EVAR vs. OAR: 6.14 ± 0.13 years vs. 6.11 ± 0.22 years, p = 0.378). The composite endpoint of MI, stroke, arrhythmia, or death was not different between groups at 30 days (EVAR vs. OAR: 12.9% vs. 14.1%, p = 0.774) or in long-term follow-up population (EVAR vs. OAR: 40.6% vs. 31.9%, p = 0.073) though there was a trend toward higher event rates in the EVAR. The composite endpoint of MI, stroke, and arrhythmia occurred in 198 patients (31%). Conclusion EVAR was associated with lower 30-day mortality rates; however, this benefit was not sustained in longer-term follow-up. There is no difference in the rates of stroke, myocardial infarction, or cardiac arrhythmia at 30 days or in long-term follow-up.
Molecular and clinical predictors of inhibitor risk and its prevention and treatment in mild hemophilia A
Authors: Castaman Giancarlo , Fijnvandraat Karin 
Published: August 2014

AbstractThe risk for inhibitor development in mild hemophilia A (factor VIII levels between 5 and 40 U/dL) is larger than previously anticipated, continues throughout life, and is particularly associated with certain mutations in F8. Desmopressin may reduce inhibitor risk by avoiding exposure to FVIII concentrates, but the heterogenous biological response to desmopressin, showing large interindividual variation, may limit its clinical use. However, predictors of desmopressin response have been recently identified, allowing the selection of the best candidates to this treatment.
Maximum likelihood estimators in linear regression models with Ornstein-Uhlenbeck process
Authors: Hu Hongchang , Pan Xiong , Xu Lifeng 
Published: August 2014

Abstract
The paper studies the linear regression model

y
t

=

x
t
T

β
+

ε
t

,

t
=
1
,
2
,
…
,
n
,

where

d

ε
t

=
λ
(
μ
−

ε
t

)

d
t
+
σ

d

B
t

,

with parameters

λ
,
σ
∈

R
+

,

μ
∈
R

and

{

B
t

,
t
≥
0
}

the standard Brownian motion. Firstly, the maximum likelihood (ML) estimators of β, λ and

σ
2

are given. Secondly, under general conditions, the asymptotic properties of the ML estimators are investigated. And then, limiting distributions for likelihood ratio test statistics of the hypothesis are also given. Lastly, the validity of the method are illuminated by two real examples.

MSC:62J05, 62M10, 60J60.