bluuebunny/crossref_metadata_2025_split huggingface dataset:
An ultra‐fast green ultra‐high‐performance liquid chromatography‐tandem mass spectrometry method for estimating the in vitro metabolic stability of zotizalkib in human liver microsomes
Authors: Attwa Mohamed W. , Abdelhameed Ali S. , Kadi Adnan A. 
Published: August 2024

Zotizalkib (ZTK, TPX‐0131) is a fourth‐generation highly effective inhibitor of wild‐type anaplastic lymphoma kinase (ALK) and ALK‐resistant mutations that can penetrate the central nervous system. It exhibited greater potency compared to all five officially approved ALK inhibitors. The aim of this study was to develop a rapid, accurate, eco‐friendly, and highly sensitive ultra‐high‐performance liquid chromatography‐tandem mass spectrometry (UHPLC‐MS/MS) method for measuring the concentration of ZTK in human liver microsomes (HLMs). The validation aspects of the current UHPLC‐MS/MS methodology in the HLMs were conducted in accordance with the bioanalytical method validation standards specified by the US Food and Drug Administration. ZTK and encorafenib were separated using an Agilent C8 column (Eclipse Plus) and an isocratic mobile phase. The calibration curve for the developed ZTK exhibited a linear relationship within the concentration range of 1–3000 ng/mL. The results from the Analytical Green‐ness Metric Approach program (0.76) suggested that the created method demonstrated a significant degree of environmental sustainability. The in vitro half‐life (t1/2) and intrinsic clearance (Clint) of ZTK were determined to be 15.79 min and 51.35 mL/min/kg, respectively that suggests the ZTK exhibits characteristics similar to those of a medication with a high extraction ratio. These approaches are crucial for the progress of novel pharmaceutical development, especially in improving metabolic stability.
Emotional dynamics of virtual reality tourism experience: An application of day reconstruction and physiological methods
Authors: Li Shanshi , Zheng Danni , Zhan Jueying 
Published: August 2024

AbstractThis study investigates how the succession of real‐time emotions during a virtual reality tourism experience can shape the retrospective assessment of such experience. A total of 363 participants were exposed to a virtual reality tourism experience while their self‐report and skin conductance data were collected. Results reveal that average pleasure dominates peak and end moments in driving consumers' post‐viewing evaluation of virtual reality tourism experience. Meanwhile, the time to emotional arousal peak was found to be a significant predictor of consumers' visit intention in the virtual reality tourism setting. The findings advance our understanding of how individuals assess virtual reality destination experience on the basis of moment‐to‐moment affective data and extend the literature on emotional dynamics and virtual reality tourism.
Nationwide Hearing Loss Trends Over Two Decades
Authors: Danis David O. , Jain Rishubh , Homer Benjamin J. , O'Brien Monica , Gall Emily K. , Noonan Kathryn Y. 
Published: August 2024

ObjectivesHearing loss (HL) is one of the most common chronic health conditions in the United States (US). This study aims to evaluate trends in HL prevalence among US adults over the past two decades.MethodsAudiometric data of adults from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 were analyzed in 2‐year intervals to evaluate changes in HL (defined as pure tone average greater than 25 dB in at least one ear) over time in using odds ratios (ORs). Multivariate logistic regression was used to control for age and sex, and linear regression was used to evaluate trends in HL prevalence over time.ResultsThe study included 13,468 participants. In adult participants (20–69 years old), HL remained stable over time, with some fluctuations ranging from 14.8% to 16.8%. In elderly participants (70‐years and older), HL remained stable over time, with some fluctuations ranging from 71.7% to 77.1%. Based on univariate and linear regression analysis, there were no differences in HL rates in the adult and elderly cohorts. Subjects 40–49 years old and adults with education level of less than high school had significant downward trends in HL prevalence over two decades (p < 0.001 and p = 0.029).ConclusionsHL prevalence may be declining in the adult population when correcting for age and gender; however, there has not been a significant downward trend for the elderly population. HL may be decreasing over time among adults 40–49 years old and with shorter education backgrounds.Level of EvidenceIV Laryngoscope, 2024
Achieving the Anomalous Far‐Red Emission of Eu3+ by Tailoring Distorted Square Antiprism Symmetry in Potassium‐Bismuth‐Phosphates
Authors: Zhang Hongzhi , Yang Zhiqin , Li Hong , Li Junpeng , Liu Conglin , Jiang Hongming , Liu Yuxin , Wang Rui , Xie Zhi , Zhu Jing 
Published: August 2024

AbstractEu3+ doped phosphors with efficient and intense 5D0‐7F4 far‐red luminescence hold significant potential in daily and agricultural illuminations. However, Eu3+ ions typically emit orange/red luminescence from 5D0‐7F1,2 transitions, and the development of high‐quality Eu3+ doped far‐red phosphors is still lacking and challenging. Herein, two potassium‐bismuth‐phosphate phosphors are developed to manipulate the coordination geometry from octahedron to distorted square antiprism, achieving intense 5D0‐7F4 far‐red emission with a high quantum efficiency of 90.5%. Specifically, formation energy calculations and transient spectral measurements reveal that Eu3+ occupies distorted square antiprism symmetric site in K6Bi13(PO4)15:Eu3+, resulting in intense 5D0‐7F4 far‐red emission. Conversely, the octahedral symmetry generates weak 5D0‐7F4 emission in K5Bi(P2O7)2:Eu3+. Moreover, K6Bi13(PO4)15:0.08Eu3+ (90%@423 K) exhibits better thermal stability compared to K5Bi(P2O7)2:0.2Eu3+ (83%@423 K). Spectral analyses and Debye temperature calculations exclude contributions from charge transfer band and structural rigidity, and elevated thermal stability is attributed to suppressed energy migration to quenching centers facilitated by smaller Eu3+ doping level in K6Bi13(PO4)15:0.08Eu3+. Finally, excellent photoelectric properties of white‐LEDs and plant growth lighting by utilizing the representative K6Bi13(PO4)15:0.08Eu3+ as red/far‐red components indicate its application potentiality. This work provides a feasible method for constructing efficient Eu3+ doped far‐red phosphors.
Epithelial–mesenchymal plasticity in cancer: signaling pathways and therapeutic targets
Authors: Wang Xiangpeng , Xue Xiaoxia , Pang Mingshi , Yu Liuchunyang , Qian Jinxiu , Li Xiaoyu , Tian Meng , Lyu Aiping , Lu Cheng , Liu Yuanyan 
Published: August 2024

AbstractCurrently, cancer is still a leading cause of human death globally. Tumor deterioration comprises multiple events including metastasis, therapeutic resistance and immune evasion, all of which are tightly related to the phenotypic plasticity especially epithelial–mesenchymal plasticity (EMP). Tumor cells with EMP are manifest in three states as epithelial–mesenchymal transition (EMT), partial EMT, and mesenchymal–epithelial transition, which orchestrate the phenotypic switch and heterogeneity of tumor cells via transcriptional regulation and a series of signaling pathways, including transforming growth factor‐β, Wnt/β‐catenin, and Notch. However, due to the complicated nature of EMP, the diverse process of EMP is still not fully understood. In this review, we systematically conclude the biological background, regulating mechanisms of EMP as well as the role of EMP in therapy response. We also summarize a range of small molecule inhibitors, immune‐related therapeutic approaches, and combination therapies that have been developed to target EMP for the outstanding role of EMP‐driven tumor deterioration. Additionally, we explore the potential technique for EMP‐based tumor mechanistic investigation and therapeutic research, which may burst vigorous prospects. Overall, we elucidate the multifaceted aspects of EMP in tumor progression and suggest a promising direction of cancer treatment based on targeting EMP.
Curvilinear relationship was found between visceral adiposity index and stress urinary incontinence among US adult women: A cross‐sectional study
Authors: Zhao Haibo , Shen Liping , Liu Yu 
Published: August 2024

AbstractAimsThe purpose of this study was to find out the relation between visceral adipose index (VAI) levels and stress urinary incontinence (SUI) in adult women.MethodsFrom the National Health and Nutrition Examination Survey (NHANES) 2007–2020, females aged 20 or above were identified for this study. Visceral adiposity was determined using the VAI score, and the assessment of urinary incontinence was carried out through a correlation questionnaire. Logistic regression models and restricted cubic spline (RCS) regression were employed to analyze the relationship between VAI levels and SUI.ResultsAmong the 6522 participants, 2672 (41.0%) were reported SUI. Multivariate logistic regression revealed significantly higher odds of SUI with increasing VAI levels (Q4 vs. Q1), adjusted odds ratio (aOR) = 1.53 (CI: 1.29−1.81, p < 0.001). RCS regression indicated a curvilinear relationship between VAI and SUI (p = 0.003). In threshold analysis, aOR for developing SUI was 1.18 (CI: 1.11–1.26, p < 0.001) for participants with VAI < 4.73, suggesting an 18% increased risk of SUI with each unit increase in VAI. No association between VAI and SUI was observed when VAI was ≥4.73.ConclusionsOur study has revealed a significant curvilinear relationship between VAI and SUI within a large and representative sample of women. Future research is necessary to evaluate the relationship between the two and explicate the underlying mechanisms of this relationship.
Partitioning method for the finite element approximation of a 3D fluid‐2D plate interaction system
Authors: Geredeli Pelin G. , Kunwar Hemanta , Lee Hyesuk 
Published: August 2024

AbstractWe consider the finite element approximation of a coupled fluid‐structure interaction (FSI) system, which comprises a three‐dimensional (3D) Stokes flow and a two‐dimensional (2D) fourth‐order Euler–Bernoulli or Kirchhoff plate. The interaction of these parabolic and hyperbolic partial differential equations (PDE) occurs at the boundary interface which is assumed to be fixed. The vertical displacement of the plate dynamics evolves on the flat portion of the boundary where the coupling conditions are implemented via the matching velocities of the plate and fluid flow, as well as the Dirichlet boundary trace of the pressure. This pressure term also acts as a coupling agent, since it appears as a forcing term on the flat, elastic plate domain. Our main focus in this work is to generate some numerical results concerning the approximate solutions to the FSI model. For this, we propose a numerical algorithm that sequentially solves the fluid and plate subsystems through an effective decoupling approach. Numerical results of test problems are presented to illustrate the performance of the proposed method.
Taste Disorders After Middle Ear Surgery: Chorda Tympani Nerve Injury and Quality of Life
Authors: Lafargue Blandine , D'Andréa Grégoire , Fabre Roxane , Alshukry Abdallah , Vandersteen Clair , Guevara Nicolas 
Published: August 2024

AbstractObjectiveTo evaluate taste disorders after middle ear surgery, their modifying factors especially chorda tympani nerve injury or underlying otologic disease. We investigated consequences of taste disorders on quality of life.Study DesignProspective cohort study.SettingMonocentric study in tertiary care center.MethodsA total of 214 patients who underwent middle ear surgery were included. Data regarding taste disorders were collected by questionnaires over a 1‐year follow‐up period.ResultsTaste disorders were reported in 42.7% at 10 days, in 23.3% at 4 months, and in 9.2% 1 year postoperatively. When the chorda tympani nerve was initially healthy, taste disorders were more frequent after its transection throughout the follow‐up period. When it was involved in a cholesteatoma or inflammatory process, postoperative taste disorders were more frequent after nerve stretching. Postoperative discomfort in daily life was rated on the Likert scale at 3.5 out of 10. Dietary modifications were reported by 25.8% of patients, and mood alterations by 15% of patients.ConclusionTaste disorders are frequent after middle ear surgery although they mostly improve in the first months. When the CTN is healthy, cutting it leads to more taste disorders than stretching it, thus advocating its preservation to prevent these symptoms. However, in cases of pathological CTN, cutting this nerve, which is sometimes necessary to control the disease, is less likely to cause taste disorders than stretching it. These taste disorders are a source of discomfort and may present risks of dietary modifications and emotional impact.
An Investigation into the Influence of Graphene Content on Achieving a High‐Performance TiO2‐Graphene Nanocomposite Supercapacitor
Authors: Naghavi Negar , Jalaly Maisam , Mohammadi Samira , Mousavi‐Khoshdel S. Morteza 
Published: August 2024

AbstractThis study presents the synthesis of TiO2‐graphene nanocomposites with varying mass ratios of graphene (2.5, 5, 10, 20 wt. %) using a facile and cost‐effective hydrothermal approach. By integrating TiO2 nanoparticles with graphene, a nanomaterial characterized by a two‐dimensional structure, unique electrical conductivity and high specific surface area, the resulting hybrid material shows promise for application in supercapacitors. The nanocomposite specimens were characterized by X‐ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, Raman microscopy, field‐emission scanning electron microscopy (FESEM), and transmission electron microscopy (TEM). Additionally, supercapacitive properties were investigated using a three‐electrode setup by cyclic voltammetry (CV), galvanostatic charge‐discharge (GCD) and electrochemical impedance spectroscopy (EIS) tests. Notably, the TiO2‐20 wt. % rGO nanocomposite exhibited the highest specific capacitance of 624 F/g at 2 A/g, showcasing superior electrochemical performance. This specimen indicated a high rate capability and cyclic stability (93 % retention after 2000 cycles). Its remarkable energy density and power density of this sample designate it as a strong contender for practical supercapacitor applications.
A Comparative Study on Characteristics and Antibacterial Capacity of Cotton Fabrics Dyed with Reactive Dye and Diospyros Mollis Extract
Authors: Nguyen Trong Tuan , Nguyen Thuy Chinh , Nguyen Thi Thu Trang , Nguyen Manh Ha , Thai Hoang 
Published: August 2024

AbstractThis article focuses on comparing the characteristics of cotton fabric dyed with Diospyros mollis extract (DME) solution and that of cotton fabric dyed with the reactive dye. The parameters of the cotton fabric after dyeing with both types of dyes were assessed, including color strength (K/S), structural morphology, infrared spectrum, antibacterial properties, UV resistance, color fastness to washing, rubbing, light, moisture absorption, breathability, and wastewater indices. The obtained results show that the K/S value of cotton fabric dyed with DME solution is slightly lower than that of cotton fabric dyed with the reactive dye, 18.52 and 19.36, respectively. The cotton fabric dyed with the reactive dye does not exhibit antibacterial activity against Escherichia coli and Staphylococcus aureus, whereas the antibacterial effectiveness against these bacteria for cotton fabric dyed with DME solution is 99.99 %. The UV protection capability of cotton fabric dyed with DME solution is superior to cotton fabric dyed with the reactive dye. The BOD/COD ratio of wastewater from the dyeing process with DME is higher than that of the reactive dye, with values of 0.70 and 0.32, respectively. The findings of this study indicate the superior ability of using DME solution as compared to the reactive dye, which is promising as a natural dye for fabric in medical applications.
Profile control and oil displacement in high temperature and salinity reservoirs: Evaluation of deformable microgel system
Authors: Pahlevani Hossein , Baghban Salehi Mahsa , Saghandali Farzin , Moghanloo Rouzbeh G. , Taghikhani Vahid 
Published: August 2024

AbstractViscoelastic microgels have been successfully used as profile control and enhanced oil recovery agents in oil reservoirs. In this paper, a novel microgel made of acrylamide monomer and 2‐Acrylamido‐2‐methylpropane sulfonic acid was synthesized using inverse emulsion polymerization. The spherical shape of microgel particles and their corresponding size distribution were confirmed by series of microscopic images. Additional tests such as morphology and swelling tests indirect characterization of structural properties via rheology tests, and viscoelastic tests of spherical microgels were performed for 5 different aqueous solutions. The flow curve of all aqueous solutions illustrated three areas of shear thinning, static state, and shear thickening representing presence of dispersed system and confirming formation of microgel suspension. According to results of the oscillatory frequency sweep test “superior” viscoelastic properties were demonstrated. Also, no structural fracture occurred in the frequency range of 0.01–100 Hz with elastic modulus of 105, 3.63, 2.4, 3, and 1.6, respectively. Furthermore, excellent swelling properties were observed in presence of monovalent, divalent ions, and brine. In addition, performance of microspheres microgel suspension (MMS) in formation water were evaluated using a micro and macro floodingexperiment setup. Due to the elastic modulus of microgel system (2.4 Pa) and its viscoelastic properties, deformation capability and the ability to maintain initial shape of microgels, the oil recovery was increased to 83.77, which was 2.02 times more than that of water flooding displacement. The MMS macro‐flooding test indicated the alteration of the core from oil‐wet to water‐wet. Also, the pressure drop created during water injection compared to during oil injection increased from 0.67 to 9.62 after treatment with MMS. The characteristics and displacement performance of a deformable microgel make it a good candidate for in‐depth gel treatment and sweep efficiency improvement.
High prevalence of medication errors in a secondary‐level Lithuanian hospital: A prospective cross‐sectional observational study
Authors: Butauskaite J. , Zumbakyte A. , Aukstikalne L. , Pancere J. , Zukaitiene S. , Karinauske E. 
Published: August 2024

AbstractAs the population continues to age, the occurrence of chronic illnesses and comorbidities that often necessitate the use of polypharmacy has been on the rise. Polypharmacy, among other factors that tend to coincide with chronic diseases, such as obesity, impaired kidney and liver function, and older age, can increase the risk of medication errors (MEs). Our study aims to evaluate the prevalence of MEs in the Internal medicine, Cardiology, and Neurology departments at the secondary‐level university hospital. We conducted a prospective observational study of 145 patients’ electronic or paper‐based data of inpatient prescriptions and patients' pharmacokinetic risk factors, such as an impairment of renal and/or hepatic function, weight, and age. All included patients collectively received 1252 prescribed drugs. The median (Q1; Q3) number of drugs per patient was 8 (7;10). At least one ME was identified in 133 out of the 145 patients, indicating a significantly higher prevalence than hypothesized (91.7% vs. 50%; p < .001). There was moderate, positive correlation between the quantity of prescribed drugs and the number of MEs, meaning that the more drugs are prescribed, the higher the number of identified MEs (Spearman's ρ = 0.428; p < .001). These findings suggest that there is a need for continuous medication education activity for prescribing physicians, continuous evaluation of prescription appropriateness to objectively identify the MEs and to contribute to more rational patient treatment.
Granular cell tumour—A case of recurrent pneumonia due to an endobronchial lesion
Authors: Mathew Alwyn , Al‐Tanjy Ahmad , Abdeen Yazan 
Published: August 2024

AbstractGranular cell tumours are rare, mostly benign masses that arise from Schwann cells. Their pathophysiology is poorly understood, but the lesions are often seen in the breast, tongue, and skin. In this case report, we discuss a 34‐year‐old patient with recurrent pneumonia. The patient had several comorbidities, and was intubated due to respiratory distress and eventually placed on tracheostomy. During the procedure, she was noted to have a right middle lobe endobronchial lesion. It was excised and identified as a granular cell tumour. The patient was later weaned off the ventilator and discharged without any complications.
Soil, forage, and weed attributes following tillage in grazed no‐tillage triticale pasture
Authors: Holman Johnathan D. , Mauler Payton S. , Obour Augustine K. , Roozeboom Kraig L. , Simon Logan M. , Assefa Yared 
Published: August 2024

AbstractGrazing annual forages in dryland cropping systems has been used to integrate crop and livestock systems, rejuvenate soils, enhance in‐field nutrient cycling and soil organic carbon (SOC), and increase net returns by eliminating harvest expenses and feed delivery. However, cattle (Bos taurus) could potentially degrade soil physical properties by increasing compaction and reducing water infiltration in no‐tillage (NT) systems. Minimum tillage (MT) may help correct some of these potential soil quality concerns. The objective of this study was to quantify MT effects on soil properties, forage mass, and weeds compared to NT in a grazed winter triticale [×Triticosecale Wittm. ex A. Camus (Secale × Triticum)] annual forage system from 2020 to 2022 near Jetmore, KS. The experiment had two tillage treatments, NT and MT (sweep plow to a depth of 5–13 cm twice during summer fallow), in a grazed continuous winter triticale cropping system. Bulk density was greater in June, pre‐till (1.31 g cm−3), compared to August, post‐till (1.23 g cm−3), across tillage treatments. The mean weight diameter of dry aggregates decreased, and wind‐erodible fraction increased with MT. Across years, the mean weight diameter of water‐stable aggregates was greater with NT compared to MT. The SOC stocks did not differ between tillage practices near the soil surface, but MT increased SOC at the 5‐ to 15‐cm depth. Nitrate (NO3‐N) concentration was 28% higher with MT compared to NT across depths at the August sampling time. Soil pH was slightly lower in NT (5.81) compared to MT (5.94). Penetration resistance was high due to frequently dry soil conditions, but there were no differences between tillage systems. Early‐season forage biomass was greater in MT compared to NT in one out of two seasons. Our findings suggest that MT could be used to mitigate adverse effects of grazing on soil bulk density in NT systems but could cause short‐term decreases in dry and wet aggregate stability and increased wind‐erodible fraction.