bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation of Ktransderived from dynamic contrast-enhanced MRI with treatment response and survival in locally advanced NSCLC patients undergoing induction immunochemotherapy and concurrent chemoradiotherapy
Authors: Wang DaQuan , Liu SongRan , Fu Jia , Zhang PengXin , Zheng ShiYang , Qiu Bo , Liu Hui , Ye YongQuan , Guo JinYu , Zhou Yin , Jiang HaiHang , Yin ShaoHan , He HaoQiang , Xie ChuanMiao , Liu Hui 
Published: June 2024

PurposeThis study aimed to investigate the prognostic significance of pretreatment dynamic contrast-enhanced (DCE)-MRI parameters concerning tumor response following induction immunochemotherapy and survival outcomes in patients with locally advanced non-small cell lung cancer (NSCLC) who underwent immunotherapy-based multimodal treatments.Material and methodsUnresectable stage III NSCLC patients treated by induction immunochemotherapy, concurrent chemoradiotherapy (CCRT) with or without consolidative immunotherapy from two prospective clinical trials were screened. Using the two-compartment Extend Tofts model, the parameters including Ktrans, Kep, Ve, and Vpwere calculated from DCE-MRI data. The apparent diffusion coefficient was calculated from diffusion-weighted-MRI data. The receiver operating characteristic (ROC) curve and the area under the curve (AUC) were used to assess the predictive performance of MRI parameters. The Cox regression model was used for univariate and multivariate analysis.Results111 unresectable stage III NSCLC patients were enrolled. Patients received two cycles of induction immunochemotherapy and CCRT, with or without consolidative immunotherapy. With the median follow-up of 22.3 months, the median progression-free survival (PFS) and overall survival (OS) were 16.3 and 23.8 months. The multivariate analysis suggested that Eastern Cooperative Oncology Group score, TNM stage and the response to induction immunochemotherapy were significantly related to both PFS and OS. After induction immunochemotherapy, 67 patients (59.8%) achieved complete response or partial response and 44 patients (40.2%) had stable disease or progressive disease. The Ktransof primary lung tumor before induction immunochemotherapy yielded the best performance in predicting the treatment response, with an AUC of 0.800. Patients were categorized into two groups: high-Ktransgroup (n=67, Ktrans＞164.3×10−3/min) and low-Ktransgroup (n=44, Ktrans≤164.3×10−3/min) based on the ROC analysis. The high-Ktransgroup had a significantly higher objective response rate than the low-Ktransgroup (85.1% (57/67) vs 22.7% (10/44), p<0.001). The high-Ktransgroup also presented better PFS (median: 21.1 vs 11.3 months, p=0.002) and OS (median: 34.3 vs 15.6 months, p=0.035) than the low-Ktransgroup.ConclusionsPretreatment Ktransvalue emerged as a significant predictor of the early response to induction immunochemotherapy and survival outcomes in unresectable stage III NSCLC patients who underwent immunotherapy-based multimodal treatments. Elevated Ktransvalues correlated positively with enhanced treatment response, leading to extended PFS and OS durations.
Evaluation of a portable, lightweight modular system to deliver high inspired oxygen to trauma casualties without the use of pressurised cylinders
Authors: Kirkman Emrys , Pope C , Wilson C , Woolley T , Watts S , Byers M 
Published: June 2024

IntroductionAdministering supplemental oxygen is a standard of care for trauma casualties to minimise the deleterious effects of hypoxaemia. Forward deployment of oxygen using pressurised cylinders is challenging, for example, logistics (weight and finite resource) and environmental risk (fire and explosion). Oxygen concentrators may overcome these challenges. Although previous studies successfully demonstrated fractional inspired oxygen (FiO2) >0.8 using oxygen concentrators and ventilators, the systems did not fulfil the size, weight and power requirements of agile military medical units. This study evaluated whether a modular system of commercially available clinical devices could supply high FiO2to either ventilated or spontaneously breathing casualties.MethodsAs a proof of principle, we configured an Inogen One G5 oxygen concentrator, Ventway Sparrow ventilator and Wenoll rebreather system to ventilate a simulated lung (tidal volume 500 mL). Casualty oxygen consumption (gas withdrawal inspiratory limb) and carbon dioxide (CO2) production (CO2added expiratory limb) were simulated (respiratory quotient of 0.7–0.8). Three circuit configurations were evaluated: open (supplementary oxygen introduced into air inlet of ventilator); semiclosed (ventilator replaces rebreather bag of Wenoll, oxygen connected to either ventilator or Wenoll); and semiclosed with reservoir tubing (addition of ‘deadspace’ tube between ventilator patient circuit and Wenoll). Data presented as mean and 95% reference range.ResultsThere were modest increases in FiO2with increasing Inogen settings in ‘open’ configuration 0.23 (0.23–0.24) and 0.30 (0.28–0.32) (Inogen output 420 and 1260 mL/min, respectively). With the ‘semiclosed’ configuration and oxygen added directly into rebreather circuit, FiO2increased to 0.36 (0.36–0.37). The addition of the ‘reservoir tubing’ elevated FiO2to 0.78 (0.71–0.85). FiO2remained stable over a 4-hour evaluation period. Fractional inspired carbon dioxide CO2increased over time, reaching 0.005 after 170 (157–182) min.ConclusionCombining existing lightweight devices can deliver high (>0.8) FiO2and offers a potential solution for the forward deployment of oxygen without needing pressurised cylinders.
Investigating the B-meson production based on the color dipole transverse momentum representation in pp collisions at the LHC
Authors: Sampaio dos Santos G. , Gil da Silveira G. , Machado M. V. T. 
Published: June 2024

AbstractIn this work the B-mesons differential cross sections in pp collisions are evaluated considering the color dipole formalism in transverse momentum representation along with the unintegrated gluon distributions (UGDs). Analytical parametrizations for UGDs including hard scale QCD evolution and those based on parton saturation framework are compared. The theoretical predictions for the B-meson production in terms of the transverse momentum distribution cover the center-of-mass energy of the Large Hadron Collider and the rapidities available at its experiments. The results for different B-mesons are compared to the corresponding measurements reported by the ATLAS, CMS, and LHCb experiments. Predictions are also performed for the nuclear modification factor as a function of the meson transverse momentum.
Tailoring the Structure, Optical and Shielding Characteristics of ZnMn2O4 Nanostructures through Sn-Doping
Authors: Heiba Zein K. , Ghannam M. M. , Badawi Ali , Mohamed Mohamed Bakr 
Published: June 2024

The current study aims to tailor the structure, optical and shielding characteristics of ZnMn2O4 nanostructures through Sn-doping. ZnMn2−xSnxO4 nanostructures were synthesized by the sol-gel technique. The sample containing 5% Sn exhibits the highest level of absorbance. ZnMn2−xSnxO4 system exhibits a maximum optical energy gap value of 2.55 eV when doped with 10% Sn, and a minimum optical energy gap value of 2.23 eV when doped with 5% Sn. The refractive index values of the samples containing 5 and 10% Sn are the highest in comparison to the other samples. The values of the non-linear optical parameters became maximum as x = 0.05. The radiation shielding constants were computed by Phy-X/PSD software. The half value length and tenth value length values reduced as ZnMn2O4 doped with Sn, implying that doped samples have better shielding capabilities than undoped ZnMn2O4. When compared to doped samples, ZnMn2O4 has the highest fast neutron removal cross-section value. ZnMn2-xSnxO4 samples demonstrate a greater rate of absorption for photons with lower energy as opposed to those with higher energy.
Synthesis and Tuning of Electronic, Optical, and Photoelectrochemical Properties of Copper Metavanadate Alloys via Alkaline Earth Metal Substitution
Authors: Danladi Fahad I. , Rawat Abhishek , Adak Abhishek Kumar , Zhang Chuzhong , Sangwan Vinod K. , Ananth Riddhi , Hersam Mark C. , Meletis Efstathios I. , Rajeshwar Krishnan 
Published: June 2024

Unlike the well-studied and technologically advanced Group III-V and Group II-VI compound semiconductor alloys, alloys of ternary metal oxide semiconductors have only recently begun to receive widespread attention. Here, we describe the effect of alkaline earth metal substitution on the optical, electronic, and photoelectrochemical (PEC) properties of copper metavanadate (CuV2O6). As a host, the Cu-V-O compound family presents a versatile framework to develop such composition-property correlations. Alloy compositions of A0.1Cu0.9V2O6 (A = Mg, Ca) photoanodes were synthesized via a time and energy-efficient solution combustion synthesis (SCS) method. The effect of introducing alkaline earth metals (Mg, Ca) on the crystal structure, microstructure, electronic, and optical properties of copper metavanadates was investigated by powder X-ray diffraction (PXRD), scanning electron microscopy (SEM), diffuse reflectance spectroscopy (DRS), transmission electron microscopy (TEM), and Raman spectroscopy. The PXRD, TEM, and Raman spectroscopy data demonstrated the polycrystalline powder samples to be mutually soluble, solid solutions of copper and alkaline earth metal metavanadates and not simple mixtures of these compounds. The DRS data showed a systematic decrease in the optical bandgap with Cu incorporation. These trends were corroborated by electronic band structure calculations. Finally, the PEC properties exhibited a strong dependence on the alloy composition, pointing to possible applicability in solar water splitting, heterogeneous photocatalysis, phosphor lighting/displays, and photovoltaic devices.
Atypical B Cells Promote Cancer Progression and Poor Response to Bacillus Calmette-Guérin in Non–Muscle Invasive Bladder Cancer
Authors: Yolmo Priyanka , Rahimi Sadaf , Chenard Stephen , Conseil Gwenaëlle , Jenkins Danielle , Sachdeva Kartik , Emon Isaac , Hamilton Jake , Xu Minqi , Rangachari Manu , Michaud Eva , Mansure Jose J. , Kassouf Wassim , Berman David M. , Siemens David R. , Koti Madhuri 
Published: June 2024

Abstract
Poor response to Bacillus Calmette-Guérin (BCG) immunotherapy remains a major barrier in the management of patients with non–muscle invasive bladder cancer (NMIBC). Multiple factors are associated with poor outcomes, including biological aging and female sex. More recently, it has emerged that a B-cell–infiltrated pretreatment immune microenvironment of NMIBC tumors can influence the response to intravesically administered BCG. The mechanisms underlying the roles of B cells in NMIBC are poorly understood. Here, we show that B-cell–dominant tertiary lymphoid structures (TLSs), a hallmark feature of the chronic mucosal immune response, are abundant and located close to the epithelial compartment in pretreatment tumors from BCG non-responders. Digital spatial proteomic profiling of whole tumor sections from male and female patients with NMIBC who underwent treatment with intravesical BCG, revealed higher expression of immune exhaustion–associated proteins within the tumor-adjacent TLSs in both responders and non-responders. Chronic local inflammation, induced by the N-butyl-N-(4-hydroxybutyl) nitrosamine carcinogen, led to TLS formation with recruitment and differentiation of the immunosuppressive atypical B-cell (ABC) subset within the bladder microenvironment, predominantly in aging female mice compared to their male counterparts. Depletion of ABCs simultaneous to BCG treatment delayed cancer progression in female mice. Our findings provide evidence indicating a role for ABCs in BCG response and will inform future development of therapies targeting the B-cell–exhaustion axis.
HUBUNGAN DIABETES MELLITUS DENGAN KATARAK DI POLIKLINIK MATA RSUD MOHAMMAD ANWAR SUMENEP TAHUN 2023
Authors: Nadziroh Ainun , Karnedi  
Published: June 2024

Pendahuluan: Katarak merupakan penyebab kebutaan terbesar kedua di dunia (65,2 juta pasien). Katarak adalah suatu kelainan pada lensa mata yang ditandai timbulnya opasitas pada lensa dan mengakibatkan berkurangnya transparansi dari lensa. Salah satu faktor risiko katarak adalah diabetes mellitus. Penelitian ini bertujuan untuk mengetahui hubungan antara diabetes mellitus dengan katarak.
Metode: Penelitian ini merupakan suatu penelitian observasional analitik dengan pendekatan cross sectional. Teknik pengambilan sampel dengan total sampling. Data penelitian adalah data sekunder yang diperoleh dari rekam medik. Analisis data dengan analisis univariat, bivariat menggunakan uji analisis fisher exact dan odds ratio.
Hasil: Jumlah sampel pada penelitian ini adalah 310 responden. 265 responden mengalami katarak (85,50%), 27 responden mengalami katarak dan diabetes mellitus (8,70%), 18 responden menderita diabetes mellitus (5,80%). Dengan menggunakan analisis fisher exact diperoleh nilai p value = 0.000 (p <0.05) yang bermakna terdapat hubungan antara diabetes mellitus dengan katarak. Nilai odds ratio = 1,667 (OR >1) yang bermakna pasien dengan diabetes mellitus berisiko 1,667 kali lebih besar menderita katarak dibandingkan tidak diabetes mellitus.
Kesimpulan: Terdapat hubungan antara diabetes mellitus dengan katarak di RSUD Moh. Anwar Sumenep. Pasien yang menderita diabetes berisiko 1,667 kali lebih besar terjadi katarak dibandingkan tidak diabetes mellitus.
Barriers to Seek Professional Help for Mental Health Scale: Development and Psychometric Validation
Authors: Sanghvi Prachi , Mehrotra Seema , Das Sumit Kumar , Sharma Manoj Kumar 
Published: June 2024

Background: Mental health conditions are highly prevalent, and both supply- and demand-side factors drive a high treatment gap. There is a dearth of socio-culturally appropriate measures to assess barriers to professional help-seeking in distressed non-treatment seekers. This study aimed to develop and validate the Barriers to Seek Professional Help for Mental Health Scale for distressed, non-treatment-seeking young adults experiencing common mental health concerns in the Indian context. Methods: The study was conducted in three phases: Phase I: development of initial measure; Phase II: scale try-out ( N = 190); and Phase III: validating the factor structure ( N = 172). Distressed, non-treatment-seeking young adults (20–35 years old) were recruited for the present study. Exploratory factor analysis (EFA) was used to identify the factor structure, and confirmatory factor analysis (CFA) was conducted to validate it. Results: EFA showed that a five-factor structure best fits the data, namely, stigma and minimization, instrumental barriers, problem perception, self-efficacy in service utilization, and negative service expectancies. CFA revealed that the model was a reasonably good fit. The scale was finalized into a 24-item measure. Internal consistency reliabilities of the scale and subscales were satisfactory. Correlation patterns of barriers subscales with help negation, help-seeking inclination, and distress support its convergent validity. Conclusion: The Barriers to Seek Professional Help for Mental Health Scale was developed, and preliminary evidence supports its reliability, construct, and convergent validity. The scale could prove valuable for assessing barriers to seeking professional help for mental health in the Indian context, developing help-seeking interventions, and examining their effectiveness in increasing the uptake of mental health services.
pT1 Staged Adenoid Cystic Carcinoma of a Young female: A Case Report
Authors: Akhtar Soubia , Afzal Yumna , Khan Ashar Masood , Malik Wardah Ramaisa , Ikram Mubasher 
Published: June 2024

Background and Aims: Adenoid cystic carcinoma is a rare and slowly progressing cancer that frequently starts in minor salivary glands, often causing no symptoms. Therefore, advanced stage at initial presentation is frequently reported. Case Presentation: We provide a case study of a 33-year-old young woman with pT1 staging adenoid cystic tumour, emphasising the clinical presentation, treatment plan and patient prognosis. Comprehensive examination and imaging tests showed that the patient had a growing mass at the base of her mobile tongue. The diagnosis was supported by histopathological examination. Based on the tumour’s small size and minimal invasion, pT1 was assigned as its staging. A comprehensive treatment strategy was used, and during surgery, the tumour was removed with precise margins that preserved both function and appearance. One-year follow-up showed no evidence of recurrence or ongoing problems. Conclusion: This case report emphasises the significance of early diagnosis, thorough treatment planning and attentive follow-up. It also highlights the infrequent presentation of disease.
Effects of Abstinence from Opioid on Sexual Functioning in Men with Opioid Use Disorder: An Observational Study
Authors: Kaur Gurneet , Sidana Ajeet , Singh Swarndeep 
Published: June 2024

Objective: Sexual dysfunction amongst persons with opioid use disorder (OUD) is quite prevalent. Research about the effects of abstinence from opioids on sexual functioning is scarce. The aim of this study is to assess the sexual functioning among men with OUD and examine the effects of abstinence from opioids on sexual functioning. Methods: An observational study was conducted at a tertiary-level multi-specialty public-funded hospital in northern India. A total of 50 men with OUD underwent a self-report–based assessment of sexual functioning using the International Index of Erectile Function (IIEF-15). Five sub-domains of IIEF-15 (i.e., erectile function, orgasmic function, sexual desire, intercourse satisfaction and overall satisfaction) were assessed at baseline, two weeks and eight weeks of abstinence from opioids. Results: A total of 44 participants out of 50 reported significant dysfunction. Most of them reported dysfunction in the domains of overall satisfaction (88%, n = 44) and sexual desire (72%, n = 36). After eight weeks of abstinence from opioids, 10 participants out of 44 reported improvement on mean assessment scores. The improvement was noted as follows: erectile function (8%), orgasmic function (2%), sexual desire (8%), intercourse satisfaction (8%) and overall satisfaction (16%) as compared to baseline. There was significant improvement in the subdomain of sexual desire ( p value .05) over the course of eight weeks of abstinence compared to baseline. Conclusion: Abstinence from opioids leads to improvement in sexual functioning over a period of eight weeks of abstinence in men with OUD.
β-hydroxybutyrate resensitizes colorectal cancer cells to oxaliplatin by suppressing H3K79 methylation in vitro and in vivo
Authors: Deng Meng , Yan Peijie , Gong Hui , Li Guiqiu , Wang Jianjie 
Published: June 2024

Abstract
Background
Ketone β-hydroxybutyrate (BHB) has been reported to prevent tumor cell proliferation and improve drug resistance. However, the effectiveness of BHB in oxaliplatin (Oxa)-resistant colorectal cancer (CRC) and the underlying mechanism still require further proof.

Methods
CRC-Oxa-resistant strains were established by increasing concentrations of CRC cells to Oxa. CRC-Oxa cell proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition (EMT) were checked following BHB intervention in vitro. The subcutaneous and metastasis models were established to assess the effects of BHB on the growth and metastasis of CRC-Oxa in vivo. Eight Oxa responders and seven nonresponders with CRC were enrolled in the study. Then, the serum BHB level and H3K79me, H3K27ac, H3K14ac, and H3K9me levels in tissues were detected. DOT1L (H3K79me methyltransferase) gene knockdown or GNE-049 (H3K27ac inhibitor) use was applied to analyze further whether BHB reversed CRC-Oxa resistance via H3K79 demethylation and/or H3K27 deacetylation in vivo and in vitro.

Results
Following BHB intervention based on Oxa, the proliferation, migration, invasion, and EMT of CRC-Oxa cells and the growth and metastasis of transplanted tumors in mice were suppressed. Clinical analysis revealed that the differential change in BHB level was associated with drug resistance and was decreased in drug-resistant patient serum. The H3K79me, H3K27ac, and H3K14ac expressions in CRC were negatively correlated with BHB. Furthermore, results indicated that H3K79me inhibition may lead to BHB target deletion, resulting in its inability to function.

Conclusions
β-hydroxybutyrate resensitized CRC cells to Oxa by suppressing H3K79 methylation in vitro and in vivo.
Transcriptomic and free monoterpene analyses of aroma reveal that isopentenyl diphosphate isomerase inhibits monoterpene biosynthesis in grape (Vitis vinifera L.)
Authors: Chen Tianchi , Xu Tao , Wang Jinnan , Zhang Tianye , Yang Jin , Feng Lixiao , Song Tiefeng , Yang Jian , Wu Yueyan 
Published: June 2024

Abstract
Background
Monoterpenes are among the most important volatile aromatic compounds contributing to the flavor and aroma of grapes and wine. However, the molecular basis of monoterpene biosynthesis has not yet been fully elucidated.

Results
In our study, transcriptomics and gas chromatography-mass spectrometry (GC-MS) were used to mine candidate genes and transcription factors involved in monoterpene biosynthesis between high-monoterpene and zero-monoterpene table grape cultivars. We found that monoterpene biosynthesis was positively correlated by the expression of five genes encoding 1-deoxy-D-xylulose-5-phosphate synthase (VvDXSs), one encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (VvHDR), three hydroxy-3-methylglutaryl-CoA synthases (VvHMGSs) and one mevalonate kinase (VvMVK), whereas the expression of one isopentenyl diphosphate isomerase (VvIDI) and one 3-hydroxy-3-methylglutaryl-CoA reductase (VvHMGR) negatively correlated monoterpene biosynthesis. Of these genes, VvIDI was selected to validate its function in monoterpene accumulation through a transient overexpression experiment, and was shown to inhibit the biosynthesis of grape linalool and α-terpineol. Meanwhile, we found that a 64-amino acid extension sequence at the N-terminus can guide the VvIDI protein to target the chloroplast.

Conclusions
The findings of this study should help to guide future functional analysis of key genes as well as mining the potential regulatory mechanism of monoterpene biosynthesis in grapes and grape products.