bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influenza Vaccinations: Older Adults’ Decision-Making Process
Authors: McIntyre Amanda , Zecevic Aleksandra , Diachun Laura 
Published: December 2013

RÉSUMÉLe but de cette étude était d’explorer les influences auto-évaluatives parmi les personnes plus âgées en décidant de prendre ou non le vaccin contre la grippe saisonnière. Trente-et-un receveurs et six non-receveurs (âgés de 67–91 ans) ont participé à six groupes de discussion à London, Ontario. Les réunions des groupes de discussion ont duré environ 60 minutes, ont été enregistrées sur bande audio-magnetique et transcrites mot à mot. Les principaux animateurs de la prise du vaccin étaient les recommandations et la confiance dans les professionnels de la santé, et la croyance en l’efficacité du vaccin. Les principaux obstacles étaient la peur des réactions indésirables et la croyance en la capacité de résistance des personnes âgées. L’Agence de la santé publique du Canada et les membres de professions paramédicales devraient sensibiliser les personnes âgées à un diagnostic précis des symptômes de la grippe, l’efficacité des vaccins et les populations qui sont à risque de contracter la grippe. L’accent devrait être mis sur la correction des idées fausses au sujet des effets indésirables.
The Evolving Role of ECOWAS and the SADC in Peace Operations: A Challenge to the Primacy of the United Nations Security Council in Matters of Peace and Security?
Authors: DE WET ERIKA 
Published: December 2013

AbstractThis article examines the evolution of military operations by the Economic Community of Western African States (ECOWAS) and the South African Development Community (SADC) over the last three decades. By looking at constitutional (treaty) developments and organizational practice, it questions whether these sub-regional organizations have displaced the primacy of the United Nations Security Council (UNSC) in matters pertaining to international peace and security, as foreseen in Articles 24(1) and 103 of the United Nations Charter (the UN Charter). The relevance of this question is underscored by the fact that ECOWAS and SADC have engaged in various peace operations since the 1990s. The article concludes that, since all the interventions under discussion were underpinned by the consent of the recognized government, it would be premature to suggest that the practice of African sub-regional organizations amounts to the emergence of a new customary right to engage in ‘first-instance enforcement action’.
Pharmacist-led medication reviews in primary care
Authors: Desborough JA , Twigg MJ 
Published: December 2013

SummaryMedication reviews in primary care are now an established and important part of the care of patients on multiple medications. In the current NHS this review has demonstrated that pharmacist-led medication reviews can reduce inappropriate prescribing and offer an efficient approach to ensuring reviews are completed. These reviews appear best operationalized with experienced pharmacists who are closely aligned with the patients and prescribers through joined up services. Further developments in pharmacists’ communication skills with patient and prescribers may offer greater benefits in the future.
Augmentation of clozapine with amisulpride: an effective therapeutic strategy for violent treatment-resistant schizophrenia patients in a UK high-security hospital
Authors: Hotham James E. , Simpson Patrick J. D. , Brooman-White Rosalie S. , Basu Amlan , Ross Callum C. , Humphreys Sharon A. , Larkin Fintan , Gupta Nitin , Das Mrigendra 
Published: November 2013

ObjectiveClozapine is used in the management of treatment-resistant schizophrenia and is effective in reducing aggression; however a subgroup of patients is poorly responsive. For violent patients in this group, there is limited literature on the use of strategies to augment clozapine with other agents. Here we present a case series of 6 schizophrenia patients, within a high-security hospital, who have a history of serious violence and who were treated with clozapine augmented with amisulpride.MethodsWe reviewed case notes and health records for evidence of violence/aggression and positive factors such as engagement in activities, and Clinical Global Impression (CGI) scores were formulated. We also examined metabolic parameters before and after augmentation.ResultsAll 6 of the patients showed clinical improvement in symptoms and a reduction in their risk of violence to others. Five patients had a reduction in number of violent/aggressive incidents, and all patients showed improvement in engagement in occupational, vocational, and/or psychological work. Metabolic parameters were largely unchanged except for 1 patient whose Body Mass Index (BMI) increased. Five patients reported side effects as unchanged or improved.ConclusionThese schizophrenia patients with a history of violence showed clinical improvement and reduced aggression and violence with amisulpride augmentation of clozapine. To our knowledge, this is the first report of an antiaggressive benefit of this combination in forensic psychiatric patients. Further studies are warranted to establish the efficacy and anti-aggressive effects of amisulpride augmentation of clozapine.
Re-contextualising design: three ways of practising sustainable architecture
Authors: Farmer Graham 
Published: November 2013

The predominant model of sustainable architecture is based on a sharp differentiation between technical and social realms that tends to situate architectural design practice in an ambiguous and marginalised position. Sustainable architecture as a whole has come to be dominated by a focus on engineering design with a related emphasis on energy efficiency and climate-change strategies that seek to improve the economic performance of buildings whilst providing little or no consideration of the wider contexts of architectural design and production. This paper argues for an expanded understanding of sustainable design and draws on ideas developed within the Philosophy of Technology to point to the broader cultural values and practices that surround particular design choices. From this perspective the work of engineers, architects, and other designers of the built environment provide settings upon which the ongoing dramas of political action are mounted.Through analysis of ‘live’ student design-build projects, the paper explores three distinct conceptualisations of sustainable design practice in which buildings are interpreted as physical manifestations of differentiated frames of design thinking that emphasise either de-contextualised, context-bound or re-contextualising design processes. Although these apparently distinct practices can be analytically differentiated, it is argued that the realisation of sustainable design practices inevitably involves a seamless interaction and interchange between the differentiated dimensions. The conclusion draws on the work of Andrew Feenberg to conceptualise sustainable design as a concrete practice whereby abstract technical concerns and social considerations seamlessly converge to produce artefacts that fit specific contexts.
Producing space, the confrontation between abstract space and everyday life: ‘I wunder if heaven got a ghetto”
Authors: Carless Tonia 
Published: November 2013

This paper is intended as a contribution to current debates about the changing conditions of urban space and uneven development. It will analyse the functions of the architectural professions in this process and how their productions prefigure the social and economic arrangement of space. It will examine these notions through analysis of Cardiff Bay and will analyse the changes occurring under late capitalism in the shift to Post-Fordist modes of accumulation. While the paper will examine the local space of Cardiff Bay, the analytical ground will be extended to the ongoing restructuring of space under the new global economies at a macro scale.Urban restructuring is most evident in the decentred metropolis of the post-modern city, the new cities for consumption. The growth or collapse of multinational capital needs to be seen as framing the occupation of space, its investment and disinvestment, and as an ongoing process, part of a systematic reprogramming of space that can and should be examined at every stage of its operations.Relocating the economic, political and social into considerations of space means that the paper will also incorporate historical analysis of modes of production and social formations. To consider space as ideological means that transfigured space must also be considered. The paper will therefore raise ideas that are directed towards the transformation of social and political space, and will examine that which identifies Lefebvre's distinction between appropriated and dominated space.
Patient compliance with the use of vaginal dilators following pelvic radiotherapy for a gynaecological cancer
Authors: Punt Lisa 
Published: December 2013

AbstractBackground: In July 2005 the national forum of gynaecological oncology nurses published the first UK best practice guidelines for the use of vaginal dilators after pelvic radiotherapy. It was written following a Cochrane review by Denton and Maher suggesting that vaginal dilators minimised vaginal stenosis and improved sexual function. Women within the author’s large cancer centre are advised to use vaginal dilators in accordance with the national recommendations.Primary outcome measure: To evaluate compliance with the use of vaginal dilators in women who have received radiotherapy for either cervix or endometrial cancer. Compliance was defined as the use of vaginal dilators two or more times a week, at 6 months.Design: One hundred and sixty-four women were posted questionnaires. Potential participants had received pelvic radiotherapy for cancer of the cervix or endometrium, were 6 months to 5 years post-treatment and disease free. The 18-point questionnaire consisted of 11 points assessing demographics and dilator use, while points 12–18 related to vaginal symptoms. Simple descriptive statistics were used to describe demographics. Mann–Whitney U and Fisher’s exact tests were used for one-at-a-time analysis of compliance against age, vaginal symptoms, treatment modality and cancer type.Results: Seventy-five completed questionnaires were returned (response rate 45.7%). Seventy-four out of the 75 respondents had been offered vaginal dilators during treatment. 89.2% (66/74) were compliant with vaginal dilation (95% confidence interval 80.1% to 94.4%).Conclusion: The compliance rate in this study was greater than seen in previously published studies. This could be due to the intervention by practitioners within the author’s cancer centre. Further prospective evaluation studies are required to explore the potential benefits of intervention at 6 months post-treatment to improve long-term compliance.
Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation
Authors: Ewer Katie J. , O’Hara Geraldine A. , Duncan Christopher J. A. , Collins Katharine A. , Sheehy Susanne H. , Reyes-Sandoval Arturo , Goodman Anna L. , Edwards Nick J. , Elias Sean C. , Halstead Fenella D. , Longley Rhea J. , Rowland Rosalind , Poulton Ian D. , Draper Simon J. , Blagborough Andrew M. , Berrie Eleanor , Moyle Sarah , Williams Nicola , Siani Loredana , Folgori Antonella , Colloca Stefano , Sinden Robert E. , Lawrie Alison M. , Cortese Riccardo , Gilbert Sarah C. , Nicosia Alfredo , Hill Adrian V. S. 
Published: November 2013

AbstractInduction of antigen-specific CD8+ T cells offers the prospect of immunization against many infectious diseases, but no subunit vaccine has induced CD8+ T cells that correlate with efficacy in humans. Here we demonstrate that a replication-deficient chimpanzee adenovirus vector followed by a modified vaccinia virus Ankara booster induces exceptionally high frequency T-cell responses (median >2400 SFC/106 peripheral blood mononuclear cells) to the liver-stage Plasmodium falciparum malaria antigen ME-TRAP. It induces sterile protective efficacy against heterologous strain sporozoites in three vaccinees (3/14, 21%), and delays time to patency through substantial reduction of liver-stage parasite burden in five more (5/14, 36%), P=0.008 compared with controls. The frequency of monofunctional interferon-γ-producing CD8+ T cells, but not antibodies, correlates with sterile protection and delay in time to patency (Pcorrected=0.005). Vaccine-induced CD8+ T cells provide protection against human malaria, suggesting that a major limitation of previous vaccination approaches has been the insufficient magnitude of induced T cells.
Controlling chloride ions diffusion in concrete
Authors: Zeng Lunwu , Song Runxia 
Published: November 2013

AbstractThe corrosion of steel in concrete is mainly due to the chemical reaction between the chloride ions and iron ions. Indeed, this is a serious threaten for reinforced concrete structure, especially for the reinforced concrete structure in the sea. So it is urgent and important to protect concrete against chloride ions corrosion. In this work, we report multilayer concrete can cloak chloride ions. We formulated five kinds of concrete A, B, C, D and E, which are made of different proportion of cement, sand and glue and fabricated six-layer (ABACAD) cylinder diffusion cloak and background media E. The simulation results show that the six-layer mass diffusion cloak can protect concrete against chloride ions penetration, while the experiment results show that the concentration gradients are parallel and equal outside the outer circle in the diffusion flux lines, the iso-concentration lines are parallel outside the outer circle and the concentration gradients in the inner circle are smaller than those outside the outer circle.
Common Pharmacophore of Structurally Distinct Small-Molecule Inhibitors of Intracellular Retrograde Trafficking of Ribosome Inactivating Proteins
Authors: Yu Shichao , Park Jewn Giew , Kahn Jennifer Nielsen , Tumer Nilgun E. , Pang Yuan-Ping 
Published: December 2013

AbstractWe reported previously (±)-2-(5-methylthiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one [(±)-Retro-2cycl] as the chemical structure of Retro-2 that showed mouse protection against ricin, a notorious ribosome inactivating protein (RIP). Herein we report our chemical resolution of (±)-Retro-2cycl, analog synthesis and cell-based evaluation showing that the two optically pure enantiomers and their achiral analog have nearly the same degree of cell protection against ricin as (±)-Retro-2cycl. We also report our computational studies explaining the lack of stereo preference and revealing a common pharmacophore of structurally distinct inhibitors of intracellular retrograde trafficking of RIPs. This pharmacophore comprises a central aromatic ring o-substituted by an aromatic ring and a moiety bearing an O or S atom attached to sp2 C atom(s). These results offer new insights into lead identification and optimization for RIP antidote development to minimize the global health threat caused by ribosome-inactivating proteins.
Diet and exercise effects on aerobic fitness and body composition in seriously mentally ill adults
Authors: Giannopoulou Ifigenia , Botonis Petros , Kostara Christina , Skouroliakou Maria 
Published: December 2013

AbstractLow exercise capacity and high obesity levels are the main characteristics of people with serious mental illness (SMI). We conducted a pilot study on the effects of a 3‐month exercise and dietary intervention on the aerobic capacity and body composition of obese adults with SMI taking Olanzapine, a second generation antipsychotic medication known to induce weight increments. Fifty adults with SMI (15 males and 35 females) followed a 3‐month weight loss intervention programme based on exercise and diet. Pre‐ and post‐intervention, a submaximal O2 exercise test was performed in order to assess O2max anthropometric and body composition measurements were also performed. All participants were obese (body mass index (BMI): 33.61 ± 0.91 kg/m2). Pre‐ and post‐intervention, a submaximal O2 exercise test on the treadmill was performed in order to assess O2max anthropometric and body composition measurements were also performed. Significant reductions in body weight, BMI, body fat and waist circumference were found from pre to post (p < 0.01). O2max was significantly improved in both genders (males: pre: 30.63 ± 2.06 vs. post: 33.19 ± 1.77 ml.kg−1 min−1, females: pre: 25.93 ± 1.01 vs. post: 29.51 ± 1.06 ml.kg−1 min−1, p < 0.01). A significant correlation was found between the change in O2max and the change in body weight and BMI (p < 0.05). Multiple regression analysis revealed that the relative change in O2max explained approximately 26% of the variance in the changes for both BMI (p = 0.07) and body weight (p = 0.06). A treatment of exercise and diet improves the aerobic capacity and body composition of obese adults with SMI, despite the use of Olanzapine.
Risk Factors for Peripheral Intravenous Catheter Failure: A Multivariate Analysis of Data from a Randomized Controlled Trial
Authors: Wallis Marianne C. , McGrail Matthew , Webster Joan , Marsh Nicole , Gowardman John , Playford E. Geoffrey , Rickard Claire M. 
Published: December 2013

Objective.To assess the relative importance of independent risk factors for peripheral intravenous catheter (PIVC) failure.Methods.Secondary data analysis from a randomized controlled trial of PIVC dwell time. The Prentice, Williams, and Peterson statistical model was used to identify and compare risk factors for phlebitis, occlusion, and accidental removal.Setting.Three acute care hospitals in Queensland, Australia.Participants.The trial included 3,283 adult medical and surgical patients (5,907 catheters) with a PIVC with greater than 4 days of expected use.Results.Modifiable risk factors for occlusion included hand, antecubital fossa, or upper arm insertion compared with forearm (hazard ratio [HR], 1.47 [95% confidence interval (CI), 1.28–1.68], 1.27 [95% CI, 1.08–1.49], and 1.25 [95% CI, 1.04–1.50], respectively); and for phlebitis, larger diameter PIVC (HR, 1.48 [95% CI, 1.08–2.03]). PIVCs inserted by the operating and radiology suite staff had lower occlusion risk than ward insertions (HR, 0.80 [95% CI, 0.67–0.94]). Modifiable risks for accidental removal included hand or antecubital fossa insertion compared with forearm (HR, 2.45 [95% CI, 1.93–3.10] and 1.65 [95% CI, 1.23–2.22], respectively), clinical staff insertion compared with intravenous service (HR, 1.69 [95% CI, 1.30–2.20]); and smaller PIVC diameter (HR, 1.29 [95% CI, 1.02–1.61]). Female sex was a nonmodifiable factor associated with an increased risk of both phlebitis (HR, 1.64 [95% CI, 1.28–2.09]) and occlusion (HR, 1.44 [95% CI, 1.30–1.61]).Conclusions.PIVC survival is improved by preferential forearm insertion, selection of appropriate PIVC diameter, and insertion by intravenous teams and other specialists.Trial Registration.The original randomized controlled trial on which this secondary analysis is based is registered with the Australian New Zealand Clinical Trials Registry (http://www.anzctr.org.au; ACTRN12608000445370).
DDGni: Dynamic delay gene-network inference from high-temporal data using gapped local alignment
Authors: Yalamanchili Hari Krishna , Yan Bin , Li Mulin Jun , Qin Jing , Zhao Zhongying , Chin Francis Y.L. , Wang Junwen 
Published: November 2013

Abstract
Motivation: Inferring gene-regulatory networks is very crucial in decoding various complex mechanisms in biological systems. Synthesis of a fully functional transcriptional factor/protein from DNA involves series of reactions, leading to a delay in gene regulation. The complexity increases with the dynamic delay induced by other small molecules involved in gene regulation, and noisy cellular environment. The dynamic delay in gene regulation is quite evident in high-temporal live cell lineage-imaging data. Although a number of gene-network-inference methods are proposed, most of them ignore the associated dynamic time delay.
Results: Here, we propose DDGni (dynamic delay gene-network inference), a novel gene-network-inference algorithm based on the gapped local alignment of gene-expression profiles. The local alignment can detect short-term gene regulations, that are usually overlooked by traditional correlation and mutual Information based methods. DDGni uses ‘gaps’ to handle the dynamic delay and non-uniform sampling frequency in high-temporal data, like live cell imaging data. Our algorithm is evaluated on synthetic and yeast cell cycle data, and Caenorhabditis elegans live cell imaging data against other prominent methods. The area under the curve of our method is significantly higher when compared to other methods on all three datasets.
Availability: The program, datasets and supplementary files are available at http://www.jjwanglab.org/DDGni/.
Contact: junwen@hku.hk
Supplementary Information: Supplementary data are available at Bioinformatics online.
Syn5 RNA polymerase synthesizes precise run-off RNA products
Authors: Zhu Bin , Tabor Stanley , Richardson Charles C. 
Published: November 2013

AbstractThe enzyme predominantly used for in vitro run-off RNA synthesis is bacteriophage T7 RNA polymerase. T7 RNA polymerase synthesizes, in addition to run-off products of precise length, transcripts with an additional non-base-paired nucleotide at the 3′-terminus (N + 1 product). This contaminating product is extremely difficult to remove. We recently characterized the single-subunit RNA polymerase from marine cyanophage Syn5 and identified its promoter sequence. This marine enzyme catalyses RNA synthesis over a wider range of temperature and salinity than does T7 RNA polymerase. Its processivity is &gt;30 000 nt without significant intermediate products. The requirement for the initiating nucleotide at the promoter is less stringent for Syn5 RNA polymerase as compared to T7 RNA polymerase. A major difference is the precise run-off transcripts with homogeneous 3′-termini synthesized by Syn5 RNA polymerase. Therefore, the enzyme is advantageous for the production of RNAs that require precise 3′-termini, such as tRNAs and RNA fragments that are used for subsequent assembly.