bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating an accessible web interface for older adults – the impact of mild cognitive impairment (MCI)
Authors: Haesner Marten , Steinert Anika , O'Sullivan Julie Lorraine , Steinhagen-Thiessen Elisabeth 
Published: November 2015

Purpose
– Cognitive changes occur with age and cognitive limitations can negatively influence computer use. Human-interaction studies show that especially older adults benefit considerably from using web platforms. The purpose of this paper is to measure the possible impact of cognitive impairment in web usability and to analyse the differences between older adults with and without cognitive impairment.

Design/methodology/approach
– In the presented pilot study, 50 older adults tested a web-based interface on a PC and tablet computer that was designed based on a styleguide for this specific user group. In two sessions participants had to conduct six tasks. In a third session older adults were left unsupervised in the laboratory where they were confronted with unexpected events triggered by a principal investigator.

Findings
– The performance results differed significantly between the two groups. Older adults with mild cognitive impairment (MCI) needed more time and were more likely to make mistakes when using a web platform. After analysing error data, it became apparent that errors made by older adults with MCI occurred due to a lack of orientation in websites.

Originality/value
– Little is known about web performance of older adults with cognitive impairment. The authors present valid data of this interesting target group and reveal their specific problems when handling a new online platform. The importance of a flat website hierarchy can be essential in developing senior friendly web pages. The authors also highlight methodological issues and illustrate the importance of qualitative information of the usability data, e.g. the different types of problems or errors.
Stock characteristics, trading behavior, and psychological pitfalls
Authors: Chang Chih-Hsiang , Huang Hsu-Huei , Chang Ying-Chih , Lin Tsai-Yin 
Published: November 2015

Purpose– The purpose of this paper is to investigate how stock characteristics influence investor trading behavior and psychological pitfalls.Design/methodology/approach– This study employs the methods of Solt and Statman (1989) and Kumar (2009) to examine investor trading activities.Findings– Good companies do not usually have good stocks, while lottery-type stocks show better price performance than other stocks. Due to the representativeness and affect heuristics, the stocks of good companies are frequently transacted, while the low-priced stocks are infrequently transacted. Moreover, investors may display the gambler’s fallacy in the trade of stocks of good companies and the overconfidence and self-attribution bias in the trade of lottery-type stocks.Research limitations/implications– Investors trading lottery-type stocks demonstrate greater maturity than those that trade stocks of good companies; however, psychological pitfalls still dominate investor trading behavior.Practical implications– The representativeness heuristic of “stocks of good companies are good stocks” results in the inclusion of stocks of good companies in a portfolio and poorer price performance, whereas the inclusion of lottery-type stocks in a portfolio brings higher returns within a short period of time.Originality/value– Compared to earlier studies that focussed on the price performance of stocks of good companies and investor trading behavior in relation to lottery-type stocks, this study aims to investigate the influence of stock characteristics on price performance, trading activities, and psychological pitfalls.
Compliance of psychotropic drug prescription with clinical practice guidelines in older inpatients
Authors: Etchepare Fanny , Pambrun Elodie , Bégaud Bernard , Verdoux Hélène , Tournier Marie 
Published: November 2015

AbstractSeveral practice guidelines were published by French regulatory agencies between 2006 and 2009 to improve psychotropic drug use in older patients. The objectives of the study were to assess compliance with these guidelines in older patients hospitalized in psychiatric units and to identify characteristics associated with compliance. A cross‐sectional study was conducted in 117 patients aged 65 years and older hospitalized in two psychiatric departments of a public hospital, at three dates randomly chosen between January and May 2014. Medical and sociodemographic characteristics were collected from electronic medical records. In all, 8% of psychotropic prescriptions were compliant with guidelines. A total of 98% of antidepressant prescriptions complied with guidelines for product selection (no tricyclics) and 72% for initial dosage (half of that recommended for younger adults). Regarding benzodiazepines, short half‐life drugs were chosen in 73% of treatments, low maintenance dosage was found in 64% of treatments, and a discontinuous administration rhythm was noted in 33% of treatments. Regarding antipsychotics, initial dosage was a quarter of the allowed initial dosage for younger adults in 39% of prescriptions and metabolic blood testing was performed in 17% of prescriptions. Neurological and cognitive tolerance was monitored in 41% and 61% of prescriptions, respectively. Few clinical factors were found to be associated with compliance or noncompliance with guidelines in older psychiatric inpatients. Practice guidelines on psychotropic drug prescription were partially respected in older inpatients. Practitioners should take into account the risks associated with non‐recommended patterns of psychotropic drug use in this vulnerable population.
A parallel hybrid metaheuristic for bicluster editing
Authors: de Sousa Filho Gilberto F. , Júnior Teobaldo L. Bulhões , Cabral Lucídio dos Anjos F. , Ochi Luiz Satoru , Protti Fábio 
Published: November 2015

AbstractThe bicluster editing problem (BEP) consists of editing (adding or removing) the edges of a bipartite graph G in order to transform it into a vertex‐disjoint union of complete bipartite subgraphs, in such a way that the sum of the weights of the edited edges is minimum. In this paper, we propose five parallel strategies for the implementation of a hybrid metaheuristic for the BEP, consisting of a GRASP with VNS as local search. Computational experiments show near‐linear speedups on Linux cluster with 64 processors and better solutions than those of the sequential approach.
Observation chart design features affect the detection of patient deterioration: a systematic experimental evaluation
Authors: Christofidis Melany J. , Hill Andrew , Horswill Mark S. , Watson Marcus O. 
Published: November 2015

AbstractAimTo systematically evaluate the impact of several design features on chart‐users’ detection of patient deterioration on observation charts with early‐warning scoring‐systems.BackgroundResearch has shown that observation chart design affects the speed and accuracy with which abnormal observations are detected. However, little is known about the contribution of individual design features to these effects.DesignA 2 × 2 × 2 × 2 mixed factorial design, with data‐recording format (drawn dots vs. written numbers), scoring‐system integration (integrated colour‐based system vs. non‐integrated tabular system) and scoring‐row placement (grouped vs. separate) varied within‐participants and scores (present vs. absent) varied between‐participants by random assignment.Methods205 novice chart‐users, tested between March 2011–March 2014, completed 64 trials where they saw real patient data presented on an observation chart. Each participant saw eight cases (four containing abnormal observations) on each of eight designs (which represented a factorial combination of the within‐participants variables). On each trial, they assessed whether any of the observations were physiologically abnormal, or whether all observations were normal. Response times and error rates were recorded for each design.ResultsParticipants responded faster (scores present and absent) and made fewer errors (scores absent) using drawn‐dot (vs. written‐number) observations and an integrated colour‐based (vs. non‐integrated tabular) scoring‐system. Participants responded faster using grouped (vs. separate) scoring‐rows when scores were absent, but separate scoring‐rows when scores were present.ConclusionOur findings suggest that several individual design features can affect novice chart‐users’ ability to detect patient deterioration. More broadly, the study further demonstrates the need to evaluate chart designs empirically.
Odorous secretions in anurans: morphological and functional assessment of serous glands as a source of volatile compounds in the skin of the treefrog Hypsiboas pulchellus (Amphibia: Anura: Hylidae)
Authors: Brunetti Andrés E. , Hermida Gladys N. , Iurman Mariana G. , Faivovich Julián 
Published: November 2015

AbstractSerous (granular or venom) glands occur in the skin of almost all species of adult amphibians, and are thought to be the source of a great diversity of chemical compounds. Despite recent advances in their chemistry, odorous volatile substances are compounds that have received less attention, and until now no study has attempted to associate histological data with the presence of these molecules in amphibians, or in any other vertebrate. Given the recent identification of 40 different volatile compounds from the skin secretions of H. pulchellus (a treefrog species that releases a strong odour when handled), we examined the structure, ultrastructure, histochemistry, and distribution of skin glands of this species. Histological analysis from six body regions reveals the presence of two types of glands that differ in their distribution. Mucous glands are homogeneously distributed, whereas serous glands are more numerous in the scapular region. Ultrastructural results indicate that electron‐translucent vesicles observed within granules of serous glands are similar to those found in volatile‐producing glands from insects and also with lipid vesicles from different organisms. Association among lipids and volatiles is also evidenced from chemical results, which indicate that at least some of the volatile components in H. pulchellus probably originate within the metabolism of fatty acids or the mevalonate pathway. As odorous secretions are often considered to be secreted under stress situations, the release of glandular content was assessed after pharmacological treatments, epinephrine administrated in vivo and on skin explants, and through surface electrical stimulation. Serous glands responded to all treatments, generally through an obvious contraction of myoepithelial cells that surround their secretory portion. No response was observed in mucous glands. Considering these morpho‐functional results, along with previous identification of volatiles from H. pulchellus and H. riojanus after electrical stimulation, we suggest that the electron‐translucent inclusions found within the granules of serous glands likely are the store sites of volatile compounds and/or their precursors. Histochemical and glandular distribution analyses in five other species of frogs of the hylid tribe Cophomantini, revealed a high lipid content in all the species, whereas a heterogeneous distribution of serous glands is only observed in species of the H. pulchellus group. The distribution pattern of serous glands in members of this species group, and the odorous volatile secretions are probably related to defensive functions.
Predictors affecting breast self‐examination practice among undergraduate female students in Klang Valley, Malaysia
Authors: Akhtari‐Zavare Mehrnoosh , A. Lattif Latiffah , Juni Muhamad Hanafiah , Md Said Salmiah , Ismail Irmi Zarina 
Published: November 2015

AbstractAimBreast cancer is the most common cancer among women worldwide, including Malaysia. In developing countries, predictors affecting breast self‐examination (BSE) practice are different. This cross‐sectional study was conducted to determine the prevalence of BSE practice and the predictors affecting BSE practice among undergraduate female students in Klang Valley, Malaysia.Material and MethodsA cross‐sectional study was conducted among 820 female undergraduate students to assess the BSE performance and related determinants of BSE practice in Klang Valley, Malaysia. Data were collected via a self‐administered structured questionnaire that was developed for this study.ResultsThe mean age of the respondents was 21.7 ± 1.2 years old. Most of them were single (96.8%), Malay (91.9%) and 19.6% of the participants performed BSE regularly. Multivariate logistic regression modeling revealed that BSE performance was more likely among women who have checked their breast with a doctor (odds ratio = 2.04, P = 0.00), and women who have personal history of breast disease (odds ratio = 4.43, P = 0.03).ConclusionThe findings showed a low BSE practice rate among young Malaysian women. Hence, the community's breast health awareness is needed to improve breast cancer prevention among young Malaysian women.
Association of interleukin‐1 receptor antagonist VNTR polymorphism and risk of pre‐eclampsia in southeast Iranian population
Authors: Salimi Saeedeh , Mohammadoo‐Khorasani Milad , Mousavi Mahdieh , Yaghmaei Minoo , Mokhtari Mojgan , Farajian‐Mashhadi Farzaneh 
Published: November 2015

AbstractAimPre‐eclampsia (PE) is an obstetric disorder that may result in maternal and neonatal mortality and morbidity. Growing evidence indicates that cytokines, such as interleukins, are involved in the pathogenesis of this complication. Hence the current study aimed to assess the possible association between interleukin‐1 receptor antagonist (IL‐1Ra) VNTR polymorphism, and PE susceptibility in southeast Iranian women.Material and MethodsThe IL‐Ra VNTR polymorphism was evaluated in 192 PE women and 186 age‐matched normotensive pregnant women by the polymerase chain reaction method.ResultsThe frequency of the A2 allele and the A2A2 genotype of IL‐Ra VNTR polymorphism was significantly lower in PE patients compared to controls: therefore, A2 allele may play a protective role in PE development (odds ratio = 0.13 95% CI, [0.04–0.03]; P < 0.0001). In addition, there was no relation between the IL‐Ra VNTR polymorphism and severity of the disease.ConclusionThe A2 allele of the IL‐Ra VNTR polymorphism could be a protective factor for PE susceptibility.
Associations between the codon 72 polymorphism of the TP53 gene and the risk of recurrent implantation failure
Authors: Feng Yi , Wu Yuan‐Yuan , Lin Xiao‐Juan , Yang Lu , Luo Zhi‐Juan , Zhou Ying‐Hui , Chen Jing , Li Ning , Lin Zhong , Zhao Xia 
Published: November 2015

AbstractAimRecurrent implantation failure (RIF) is the most common cause of unsuccessful pregnancy after assisted reproductive techniques. The tumor protein P53 (TP53) codon 72 polymorphism (G‐C transversion) has been explored in susceptibility to RIF, but inconclusive results have been reported. The aim of this article is to estimate the associations between the TP53 codon 72 polymorphism and the risk of RIF.Materials and MethodsA comprehensive search for relevant articles was conducted. The odds ratios (ORs) and 95% confidence intervals (CIs) for CC + GC versus GG, CC versus GC + GG, CC versus GG, GC versus GG genotypes, and C versus G allele, were estimated. Publication bias was explored. Statistical analyses were performed using RevMan 5.2 and Stata 11.0 software.ResultsA total of five case‐control studies in five articles with 417 RIF cases and 325 controls were included. An overall random effect OR of 1.20 (95% CI, 0.66–2.19; P = 0.55) in the dominant model (CC + GC vs GG) was found. The results suggested that a lack of increased or decreased risks were found in individuals who carried the CC homozygote and heterozygote GC, in comparison with the homozygote GG. However, in subgroup analysis by ethnicity, a significantly increased risk was observed among Latin Americans in the dominant model (OR, 1.56; 95% CI, 1.04–2.33; P = 0.03).ConclusionsThis meta‐analysis shows that the TP53 codon 72 polymorphism is not associated with RIF risk in the overall population; however, associations were found in the Latin American population.
Grounding Causal Closure
Authors: Tiehen Justin 
Published: November 2015

AbstractWhat does it mean to say that mind‐body dualism is causally problematic in a way that other mind‐body theories, such as the psychophysical type identity theory, are not? After considering and rejecting various proposals, I advance my own, which focuses on what grounds the causal closure of the physical realm. A metametaphysical implication of my proposal is that philosophers working without the notion of grounding in their toolkit are metaphysically impoverished. They cannot do justice to the thought, encountered in every introductory class in the philosophy of mind, that dualism has a special problem accounting for mental causation.
Concomitant nodal involvement by Langerhans cell histiocytosis and Hodgkin's lymphoma
Authors: Geurten Claire , Thiry Albert , Jamblin Paul , Demarche Martine , Hoyoux Claire 
Published: November 2015

AbstractA 10‐year‐old girl with a family history of Hodgkin's lymphoma presented with a 2 month history of cervical lymphadenopathy and weight loss. Biopsy indicated concomitant nodal involvement by Langerhans cell histiocytosis and Hodgkin's lymphoma. Such an association is rare, especially so in children, but is not an isolated phenomenon, thereby prompting the question of whether Langerhans cell histiocytosis is a reactive or a neoplastic process.
What Goes into a Medal: Women's Inclusion and Success at the Olympic Games*
Authors: Noland Marcus , Stahler Kevin 
Published: November 2015

ObjectiveThis article examines determinants of women's participation and performance in the Olympics.MethodsThe authors analyze total and sport‐specific data on female Olympic athletic participation and medaling at the Summer Games between 1960 and 2012, controlling for a number of country‐level socioeconomic variables.ResultsOlympic outcomes are generated by a complex process involving the socioeconomic status of women and, more weakly, societal attitudes. Medal performance is affected by large‐scale boycotts. But the historical record for women's medal achievement is utterly distorted by the doping program in the former East Germany. At its peak, the program was responsible for 17 percent of the medals awarded to women, equivalent to the medal hauls of the Soviet or American team in 1972.ConclusionHeightened success and performance for women at the Olympics is a reflection of environments more conductive to women's general success in education, the labor force, and society.
The Role of Religion in Environmental Attitudes
Authors: Arbuckle Matthew B. , Konisky David M. 
Published: November 2015

ObjectiveThis article examines the role of religion in public attitudes about the environment. While some have found that various aspects of theology and religious practices are responsible for lower levels of concern about the environment, the overall evidence is inconclusive, largely because the typical sample size is insufficient to gain insight into differences between religious traditions.MethodsWe use ordered logistic regression to analyze data from the 2010 Cooperative Congressional Election Study, a large survey that allows us to unpack the relationships among religious affiliation, religiosity, and environmental attitudes.ResultsOur results show that members of Judeo‐Christian traditions are less concerned about environmental protection than their nonreligious peers, and that religiosity somewhat intensifies these relationships for evangelical Protestants, Catholics, and mainline Protestants.ConclusionWhile the results generally support traditional arguments that religion depresses concern about the environment, they also reveal considerable variation across and within religious traditions.
Practicing statistics by creating exercises for fellow students
Authors: Bebermeier Sarah , Reiss Katharina 
Published: November 2015

SummaryThis article outlines the execution of a workshop in which students were encouraged to actively review the course contents on descriptive statistics by creating exercises for their fellow students. In a first‐year statistics course in psychology, 39 out of 155 students participated in the workshop. In a subsequent evaluation, the workshop was assessed as useful and appropriate to encourage students to practice statistics and to become prepared for the exam.
Relative Rates of Amino Acid Import via the ABC Transporter GlnPQ Determine the Growth Performance of Lactococcus lactis
Authors: Fulyani Faizah , Schuurman-Wolters Gea K. , Slotboom Dirk-Jan , Poolman Bert 
Published: November 2015

ABSTRACT

The GlnPQ transporter from
Lactococcus lactis
has the remarkable feature of having two substrate-binding domains (SBDs) fused to the N terminus of the transmembrane domain (TMD), and thus four SBDs are present in the homodimeric complex. Although X-ray structures and ligand binding data are available for both SBDs, little is known of how different amino acids compete with each other for transport via GlnPQ. Here we show GlnPQ has a broader substrate specificity than previously thought, with the ability to take up asparagine, glutamine, and glutamic acid, albeit via different routes and with different affinities. Asparagine and glutamine compete with each other at the level of binding to SBD1 and SBD2 (with differences in dissociation constant), but at the same time SBD1 and SBD2 compete with each other at the level of interaction with the translocator domain (with differences in affinity constant and rate of transport). Although glutamine transport via SBD1 is outcompeted by physiological concentrations of asparagine, SBD2 ensures high rates of import of the essential amino acid glutamine. Taken together, this study demonstrates that even in the presence of competing asparagine concentrations, GlnPQ has a high capacity to transport glutamine, which matches the high needs of the cell for glutamine and glutamate.

IMPORTANCE
GlnPQ is an ATP-binding cassette (ABC) transporter for glutamine, glutamic acid, and asparagine. The system is essential in various Gram-positive bacteria, including
L. lactis
and several pathogens. Here we show how the amino acids compete with each other for binding to the multiple SBDs of GlnPQ and how these SBDs compete with each other for substrate delivery to the transporter. Overall, our results show that GlnPQ has evolved to transport diverse substrates via different paths and to optimally acquire the abundant and essential amino acid glutamine.
Properties of lead-free BZT–BCT ceramics synthesized using nanostructured ZnO as a sintering aid
Authors: Tuan Dang Anh , Tung Vo Thanh , Chuong Truong Van , Hong Le Van 
Published: November 2015

This article studies the microstructure and piezoelectric properties of low sintering temperature lead-free ceramics [Formula: see text]-doped with ZnO nanoparticles (noted as 0.48BZT-y, y is content of ZnO in wt%, y =0.00, 0.05, 0.10, 0.15, 0.20 and 0.25). The obtained results of Raman scattering and dielectric measurements have confirmed that [Formula: see text] has occupied B site, to cause a deformation in the ABO3-type lattice of the 0.48BZT-y compounds. The 0.15 wt% ZnO-doped ceramic sintered at 1350[Formula: see text]C exhibited excellent piezoelectric parameters: [Formula: see text], [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text]. The obtained results indicate that the high-quality lead-free BZT–BCT ceramic could be successfully synthesized at a low sintering temperature of 1350[Formula: see text]C by doping an appropriated amount of ZnO.