bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of dermal substitutes in the surgical treatment of full‐thickness wounds: Outcomes of an international survey
Authors: van den Bosch Anna S. , Verwilligen Robin A. F. , Pijpe Anouk , Bosma Eelke , Lucas Ymke , van Zuijlen Paul P. M. , Middelkoop Esther ,   The National Burn Care, Education & Research Group The Netherlands
Published: July 2024

AbstractDermal substitutes have been introduced to improve the outcome of wound healing. Despite proven efficacy in trials, these skin constructs do not have a firm footing in treatment protocols. This survey aimed to gain insight into the international perspective on dermal substitutes. An open, voluntary and anonymous internet‐based international survey was conducted. Eligible to complete the survey were professionals involved in the surgical treatment of patients with wounds. Information was collected on participant demographics, appointed facilitators, barriers, indications and contraindications related to the use of dermal substitutes, as well as participants' perceptions on the current available evidence and treatment protocols. A total of 148 professionals from 30 countries completed the survey. The majority of participants were male (57%), with 60% being plastic surgeons. Eighty‐three percent of the professionals had experience in using dermal substitutes. The primary facilitators were ‘increased scar elasticity’ and ‘reduction of contractures’, while primary barriers included ‘costs’ and ‘contamination risk’. Sixty‐two percent of the professionals acknowledged the efficacy of dermal substitutes; however, the majority emphasised the absence of clear indications and treatment protocols. This study emphasises the acknowledged efficacy of dermal substitutes while highlighting the need for clearer indications and treatment protocols.
The Caring Life Course Theory: Opening new frontiers in care—A cardiac rehabilitation example
Authors: Pinero de Plaza Maria Alejandra , Hutchinson Claire , Beleigoli Alline , Tieu Matthew , Lawless Michael , Conroy Tiffany , Feo Rebecca , Clark Robyn A. , Dafny Hila , McMillan Penelope , Allande‐Cussó Regina , Kitson Alison A. 
Published: July 2024

AbstractAim(s)To operationalize the Caring Life Course Theory (CLCT) as a framework for improving cardiac rehabilitation (CR) engagement and informing ways to address disparities in rural, low socio‐economic areas.MethodsA secondary analysis of data collected from 15 CR programmes to identify CR patterns through the CLCT lens using a mixed‐methods approach. All analytical processes were conducted in NVivo, coding qualitative data through thematic analysis based on CLCT constructs. Relationships among these constructs were quantitatively assessed using Jaccard coefficients and hierarchical clustering via dendrogram analysis to identify related clusters.ResultsA strong interconnectedness among constructs: ‘care from others’, ‘capability’, ‘care network’ and ‘care provision’ (coefficient = 1) highlights their entangled crucial role in CR. However, significant conceptual disparities between ‘care biography’ and ‘fundamental care’ (coefficient = 0.4) and between ‘self‐care’ and ‘care biography’ (coefficient = 0.384615) indicate a need for more aligned and personalized care approaches within CR.ConclusionThe CLCT provides a comprehensive theoretical and practical framework to address disparities in CR, facilitating a personalized approach to enhance engagement in rural and underserved regions.ImplicationsIntegrating CLCT into CR programme designs could effectively address participation challenges, demonstrating the theory's utility in developing targeted, accessible care interventions/solutions.Impact

Explored the challenge of low CR engagement in rural, low socio‐economic settings.

Uncovered care provision, transitions and individual care biographies' relevance for CR engagement.

Demonstrated the potential of CLCT to inform/transform CR services for underserved populations, impacting practices and outcomes.

Reporting MethodEQUATOR—MMR‐RHS.Patient ContributionA consumer co‐researcher contributed to all study phases.
Evidence for routine brain‐to‐pelvis imaging and antiplatelet therapy in patients diagnosed with fibromuscular dysplasia
Authors: Østergaard Mikkel Landgraff , Hjort Niels , Buus Niels Henrik , Reinhard Mark 
Published: July 2024

AbstractFibromuscular dysplasia (FMD) is a disease of the musculature of arterial walls leading to stenoses, aneurysms, and dissections. The purpose of this report was to summarize the evidence for (1) one‐time routine imaging from brain‐to‐pelvis and (2) lifelong antiplatelet therapy, for example, aspirin, for patients diagnosed with FMD as suggested by an international consensus report from 2019.PubMed was systematically searched, and the evidence providing a basis for the current consensus points, as well as articles published since, were reviewed. In four registries evaluating patients with FMD, the prevalence of multivessel involvement, aneurysms, and dissections was reported to be 43.5%–66.3%, 21.6%–30.6%, and 5.6%–28.1%, respectively. Any antiplatelet drug was used in 72.9% of patients, and aspirin was prescribed in up to 70.2% of patients. Based on the high prevalence of vascular manifestations, their associated morbidity, and the potential for endovascular or surgical intervention, the suggestion of one‐time brain‐to‐pelvis screening with computed tomography angiography or magnetic resonance angiography is well supported. Contrarily, the evidence to support the consensus statement of lifelong antiplatelet therapy to all patients in the absence of contraindications is more uncertain since a beneficial effect has not been demonstrated specifically in patients with fibromuscular dysplasia. Therefore, until the efficacy and safety of primary thromboprophylaxis have been demonstrated in this patient group specifically, it may be equally appropriate to only use antiplatelet agents in patients with a clear indication after individual evaluation according to risk factors for thrombotic and thromboembolic complications.
Is evidence‐based practice justified?—A philosophical critique
Authors: Berg Henrik 
Published: July 2024

AbstractBackgroundEvidence‐based practice is the principle governing a range of healthcare practices and beyond. However, it has suffered from a lack of philosophical rigour. This paper sets out to analyse the epistemological basis of evidence‐based practice.MethodThe paper uses a conceptual analysis. First, it describes the implicit epistemology at work in evidence‐based practice. Second, it evaluates the implicit epistemological basis.ResultsThe analysis indicates that evidence‐based practice lacks an explicit epistemological basis. It shows, moreover, that the implicit epistemological basis is untenable.ConclusionThere is a need to re‐think the epistemological basis for evidence‐based practice. Evidence‐based practice is out of touch with developments within philosophy of science.
Farmed fish welfare research status in Latin America: A review
Authors: Linares‐Cordova Joel Fitzgerald , Roque Ana , Ruiz‐Gómez María de Lourdes , Rey‐Planellas Sonia , Boglino Anaïs , Rodríguez‐Montes de Oca Gustavo Alejandro , Ibarra‐Zatarain Zohar 
Published: July 2024

AbstractLatin America (LATAM) plays an important role in the world's production of aquatic animals and is the second most productive region in the world. Chile, Ecuador, Brazil, Mexico, Colombia, and Perú contribute 87% of LATAM aquaculture production. The fish welfare in aquaculture is of increasing public concern globally, and LATAM is no exception, growing in importance for fish farmers, authorities, and scientists. Although the topic is somewhat controversial, the welfare status of farmed fish has direct implications for their production and the sustainability of the industry. Therefore, this study analyses scientific papers on animal welfare in farmed fish, from the six countries in LATAM with the highest aquaculture production. The main objectives were to quantify the number of papers published between 2000 and 2023 on fish welfare by using scientific databases. A total of 285 papers were found for the period analysed. The country with the largest number of publications was Brazil (75.79%), followed by Chile (13.33%), Mexico (7.02%), Peru (1.75%), Ecuador, and Colombia (1.05%). Nile tilapia was the most studied species, appearing in 30.18% of the publications, with most of the studies mainly dealing with nutrition (32.28%). The growth of aquaculture is leading to joint efforts to generate knowledge on welfare issues, especially in poorly studied species with high production, to create policies that help minimize welfare risks. Given this, the insights generated by this review could be a useful addition to approaches investigating the trends and concepts of fish welfare in LATAM.
Assessments of multiple precipitation products and application in hydrodynamic simulations: A case of casualty‐inducing mountain torrents in Sichuan, Southwest China
Authors: Luo Hongxin , Lin Zhiqiang , Chen Haimeng , Xiao Dixiang , Chen Gong , Su Dongsheng 
Published: July 2024

AbstractMountain torrents are frequent and severe hazards, causing serious economic losses and personnel casualties, and in particular, they are the most dangerous threat in the complex terrain. Multi‐source precipitation products should be used to drive the hydrological models to improve understanding of the processes of mountain torrents. Fifteen sets of precipitation products are evaluated against the ground observations in situ within a serious mountain torrent caused by a severe rainstorm at June 26, 2020 in Sichuan. The multi‐source merged precipitation products performed better than the others. Satellite‐based precipitation performed better than model‐based products, while IMERG‐Early and FY2G performed better than other satellite‐based precipitation products. The reanalysis datasets are relatively worse than the observed products. The operational NWPs strongly underestimated precipitation in the mountainous areas. Furthermore, the related floods caused by the rainstorm is simulated based on various precipitation products by a raster‐based hydrodynamic two‐dimensional model of FloodArea. Most observation‐based precipitation products represented the flooding area well, while the model‐based precipitation products underestimated the severity of the mountain torrents. Finally, the risk of mountain torrents under variant return‐period rainfall is analyzed. The result shows the potential of real‐time torrent monitoring and forecasting using high‐resolution DEM and precipitation products.
Surpassing light inhomogeneities in structured‐illumination microscopy with FlexSIM
Authors: Soubies Emmanuel , Nogueron Alejandro , Pelletier Florence , Mangeat Thomas , Leterrier Christophe , Unser Michael , Sage Daniel 
Published: July 2024

AbstractSuper‐resolution structured‐illumination microscopy (SIM) is a powerful technique that allows one to surpass the diffraction limit by up to a factor two. Yet, its practical use is hampered by its sensitivity to imaging conditions which makes it prone to reconstruction artefacts. In this work, we present FlexSIM, a flexible SIM reconstruction method capable to handle highly challenging data. Specifically, we demonstrate the ability of FlexSIM to deal with the distortion of patterns, the high level of noise encountered in live imaging, as well as out‐of‐focus fluorescence. Moreover, we show that FlexSIM achieves state‐of‐the‐art performance over a variety of open SIM datasets.
Patient racism toward nurses in a divided society: The case of Jews and Arabs in Israel
Authors: Halamish‐Leshem Riki , Bokek‐Cohen Ya'arit , Tarabeih Mahdi , Azuri Pazit 
Published: July 2024

AbstractAimThis study examines whether racism exists among Jewish and Arab patients in Israel, as reflected in patient preference for receiving treatment from a nurse with the same ethnic background.BackgroundWe examine the relationship between racism and the level of trust in a nurse from a different ethnic group than the patient, as well as the preferred level of social distance, in the context of ongoing conflicts between the Jewish majority and the Arab minority in Israel.MethodsA cross‐sectional study was conducted using a unique study questionnaire that asked 534 Jewish and 478 Arab respondents to express their preference for an Arab and a Jewish nurse.ResultsAmong both the Jews and the Arabs, there is a similar tendency of racism toward nurses of the dissimilar ethnic group. This racism was also prevalent among participants who live in a mixed environment or those who studied or are studying and worked or work in a mixed environment. As the trust in nursing staff members from the other group increases, the level of racism decreases. The greater the social distance the participants felt from the members of the other group, the more racist the attitudes they expressed.ConclusionsBoth Jews and Arabs preferred to be treated by nurses of their own ethnic group. In contrast to the contact hypothesis theory, participants who live in a mixed environment did not express fewer racist preferences. We conclude with some useful practical suggestions aimed at decreasing racism in health care.Clinical RelevanceFindings imply that prospective patients prefer to receive nursing care from nurses of their own ethnic group and trust these nurses more than they trust nurses of different ethnic group.
High viral loads combined with inflammatory markers predict disease severity in hospitalized COVID‐19 patients: Results from the NOR‐Solidarity trial
Authors: Viermyr Hans‐Kittil , Halvorsen Bente , Sagen Ellen Lund , Michelsen Annika E , Barrat‐Due Andreas , Kåsine Trine , Nezvalova‐Henriksen Katerina , Dyrhol‐Riise Anne Ma ,   The Nor‐Solidarity Consortium, Lerum Tøri Vigeland , Müller Fredrik , Tonby Kristian , Tveita Anders , Aukrust Pål , Trøseid Marius , Ueland Thor , Dahl Tuva Børresdatter 
Published: July 2024

AbstractObjectivesTo investigate temporal changes in the association between SARS‐CoV2 viral load (VL) and markers of inflammation during hospitalization, as well as the ability of these markers alone or in combination to predict severe outcomes.MethodsSerial oropharyngeal and blood samples were obtained from hospitalized COVID‐19 patients (n = 160). Levels of inflammatory markers and oropharyngeal VL were measured during hospitalization (admission, days 3–5, and days 7–10) and related to severe outcomes (respiratory failure/intensive care unit admission).ResultsElevated admission levels of IL (interleukin)‐6, IL‐33, IL‐8, monocyte chemoattractant protein‐1 (MCP‐1), interferon‐γ‐induced protein 10 (IP‐10), IL‐1β, and IL‐1Ra were associated with severe outcomes during hospitalization. Although no inflammatory markers correlated with VL at baseline, there was a significant correlation between VL and levels of IP‐10 and MCP‐1 at days 3–5, accompanied by IL‐8 and IL‐6 at days 7–10. Finally, there was a seemingly additive effect of IP‐10, MCP‐1, and IL‐6 in predicting severe outcomes when combined with high VL at baseline.ConclusionsAn increasing number of inflammatory markers were associated with VL during the first 10 days of hospitalization, and several of these markers were associated with severe outcomes, in particular when combined with elevated VL. Future studies should assess the potential for combining antiviral and immunomodulatory treatment, preferably guided by viral and inflammatory biomarkers, for the selection of high‐risk patients.
‘Who's to blame?’ matters: The role of attributions in employees' emotional and behavioural responses to career inaction
Authors: Wang Zhen , Zhu Yin , Jiang Fubin 
Published: July 2024

AbstractCareer inaction, or failing to act adequately for a period of time to make a desired change in one's career, is quite common in the workplace. Despite this, research regarding how it affects employees at work is very limited. Using attribution theory and stress research, we propose an integrated view of how employees interpret and respond to career inaction differently. Specifically, we establish the idea of blame attributions for career inaction (i.e., self‐ and other‐directed blame attribution) and investigate how they relate to employees' emotional and behavioural responses to career inaction. We conducted three studies to address the research questions: a scenario‐based experiment with 315 workers, a three‐wave survey with 302 full‐time employees and a daily diary study of 123 hospital nurses across five consecutive working days. The findings revealed that when faced with career inaction, employees who blame themselves are more likely to experience anxiety, while those who blame others tend to experience anger. Anxiety and anger are further linked to work withdrawal and interpersonal deviance respectively. Overall, we contribute to the advancement of career inaction theory and career management practices.
Incidence, diagnosis, and management of orofacial pain among new patients receiving tertiary care in Thailand: A 6‐year retrospective study comparing before and during the COVID‐19 outbreak
Authors: Uma Uthai , Sae‐tia Klafan , Riewruja Yanisa , Duphong Panuwat , Srisathaporn Asamapon 
Published: July 2024

AbstractBackgroundThere is insufficient data on orofacial pain related to the COVID‐19 outbreak in Thailand.ObjectiveTo investigate the incidence, diagnosis and management of orofacial pain among new patients over the last 6 years, before and during the COVID‐19 outbreak.MethodsMedical records from new patients who first visited Chulalongkorn Dental Hospital between 2017 and 2022 were retrospectively investigated. The sample size was determined, and proportional stratified random sampling was employed to distribute the sample number proportionally across each year. The hospital number of each patient was randomised using online software as a sampling strategy. A data collection form was developed and used to gather information from the digital data system.ResultsAt the first visit, 770 out of 1359 patients (56.7/100 people, 95% CI: 54.0–59.3) reported orofacial pain defined as acute, chronic and unclassified pain. The most common chief complaints based on the AAOP classification were odontogenic pain (90.00%) and temporomandibular disorders (6.10%). The top three provisional modified ICD‐10‐TM diagnoses among these patients were pulp diseases (21.95%), impacted teeth (20.65%) and dental caries (9.09%). 81.87% of dental students' provisional diagnoses matched the final diagnoses given by dental specialists. Only 63.38% of orofacial pain patients were completely managed during the COVID‐19 pandemic with common procedures being surgical removal, extraction and root canal therapy.ConclusionHalf of Thai dental patients seeking tertiary care at a university dental hospital reported orofacial pain, which was not impacted by the COVID‐19 pandemic. In contrast, dysfunction‐related problems in the orofacial area significantly increased during the pandemic.
Deep learning and explainable artificial intelligence for investigating dental professionals' satisfaction with CAD software performance
Authors: Mai Hang‐Nga , Win Thaw Thaw , Kim Hyeong‐Seob , Pae Ahran , Att Wael , Nguyen Dang Dinh , Lee Du‐Hyeong 
Published: July 2024

AbstractPurposeThis study aimed to examine the satisfaction of dental professionals, including dental students, dentists, and dental technicians, with computer‐aided design (CAD) software performance using deep learning (DL) and explainable artificial intelligence (XAI)‐based behavioral analysis concepts.Materials and MethodsThis study involved 436 dental professionals with diverse CAD experiences to assess their satisfaction with various dental CAD software programs. Through exploratory factor analysis, latent factors affecting user satisfaction were extracted from the observed variables. A multilayer perceptron artificial neural network (MLP‐ANN) model was developed along with permutation feature importance analysis (PFIA) and the Shapley additive explanation (Shapley) method to gain XAI‐based insights into individual factors' significance and contributions.ResultsThe MLP‐ANN model outperformed a standard logistic linear regression model, demonstrating high accuracy (95%), precision (84%), and recall rates (84%) in capturing complex psychological problems related to human attitudes. PFIA revealed that design adjustability was the most important factor impacting dental CAD software users' satisfaction. XAI analysis highlighted the positive impacts of features supporting the finish line and crown design, while the number of design steps and installation time had negative impacts. Notably, finish‐line design‐related features and the number of design steps emerged as the most significant factors.ConclusionsThis study sheds light on the factors influencing dental professionals' decisions in using and selecting CAD software. This approach can serve as a proof‐of‐concept for applying DL‐XAI‐based behavioral analysis in dentistry and medicine, facilitating informed software selection and development.
Preoperative factors predicting poor therapeutic efficacy of holmium laser enucleation of the prostate in patients with benign prostatic hyperplasia
Authors: Watanabe Kyohei , Otsuka Atsushi , Kitagawa Yuichi , Sano Asuka , Sato Ryo , Matsushita Yuto , Watanabe Hiromitsu , Tamura Keita , Motoyama Daisuke , Ito Toshiki , Takada Sanki , Miyake Hideaki 
Published: July 2024

AbstractObjectivesWe assessed preoperative factors predicting the poor therapeutic efficacy of holmium laser enucleation of the prostate (HoLEP) in benign prostatic hyperplasia (BPH) patients.MethodsThe present study included 159 patients who underwent HoLEP between August 2015 and June 2021 at our institution. Overall therapeutic efficacy was divided into good and poor therapeutic efficacies according to changes in the international prostate symptom score (IPSS), IPSS quality of life (IPSS‐QOL), and the maximum urinary flow rate. Patients were divided into good and poor therapeutic efficacy groups based on findings obtained 3 months after HoLEP, and comparative assessments were performed between the two groups.ResultsThe therapeutic efficacy of HoLEP was poor in 53 (33.3%) out of 159 patients. Intravesical prostatic protrusion (IPP), IPSS, IPSS‐QOL, post‐void residual volume (PVR), and the presence of overactive bladder (OAB) were significantly higher in the poor therapeutic efficacy group than in the good therapeutic efficacy group. A multivariable analysis of several factors identified the preoperative presence of OAB and short IPP as independent risk factors for the poor therapeutic efficacy of HoLEP. When treatment efficacy was divided according to risk factors, poor therapeutic efficacy was observed in only 14% of patients with prolonged IPP and the absence of OAB.ConclusionsThe therapeutic efficacy of HoLEP may be poor in patients with OAB and short IPP, resulting in the significant deterioration of lower urinary tract symptoms. Accordingly, it is important to consider the presence or absence of OAB and IPP measurements when selecting indications for HoLEP.