bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the Relationship between Semantic Processing and Thought Disorder Symptoms in Schizophrenia
Authors: Tan Eric Josiah , Neill Erica , Rossell Susan Lee 
Published: August 2015

AbstractAberrant semantic processing has been linked to the etiology of formal thought disorder (TD) symptoms in schizophrenia. In this cross-sectional study, two prominent theories, overactivation and disorganized structure of semantic memory (SM), were examined in relation to TD symptoms using the continuum approach across two established semantic tasks (direct/indirect semantic priming and categorical fluency). The aim was to examine the validity of the two TD theories in relation to TD symptoms in schizophrenia. Greater direct and indirect priming, fluency productivity and category errors were expected if the data supported the overactivation theory. Reduced fluency productivity and increased category errors would be characteristic of disorganized storage. Fifty-seven schizophrenia/schizoaffective disorder patients and 48 controls completed a clinical assessment and the semantic tasks. There was significantly reduced direct priming in patients compared to controls (p<.05), while indirect priming was not significantly different; there was no association between TD and degree of priming. Patients produced more category-inappropriate words (p<.005) than controls, which was related to increasing severity of circumstantiality. The pattern of results was more indicative of a disorganized SM storage problem in this sample. This phenomenon may underlie some TD symptoms in general schizophrenia. The findings strengthen the relationship between SM deficits and TD symptoms, though this appears to differ between individual symptoms. The authors discuss the value of the continuum approach in addressing research questions in TD etiology. Given low levels of TD in this study, replication of these findings in a sample with greater TD is desirable. (JINS, 2015, 21, 629–638)
Absorption and Phase Contrast X-Ray Imaging in Paleontology Using Laboratory and Synchrotron Sources
Authors: Bidola Pidassa , Stockmar Marco , Achterhold Klaus , Pfeiffer Franz , Pacheco Mírian L.A.F. , Soriano Carmen , Beckmann Felix , Herzen Julia 
Published: August 2015

AbstractX-ray micro-computed tomography (μCT) is commonly used for imaging of samples in biomedical or materials science research. Owing to the ability to visualize a sample in a nondestructive way, X-ray μCT is perfectly suited to inspect fossilized specimens, which are mostly unique or rare. In certain regions of the world where important sedimentation events occurred in the Precambrian geological time, several fossilized animals are studied to understand questions related to their origin, environment, and life evolution. This article demonstrates the advantages of applying absorption and phase-contrast CT on the enigmatic fossil Corumbella werneri, one of the oldest known animals capable of building hard parts, originally discovered in Corumbá (Brazil). Different tomographic setups were tested to visualize the fossilized inner structures: a commercial laboratory-based μCT device, two synchrotron-based imaging setups using conventional absorption and propagation-based phase contrast, and a commercial X-ray microscope with a lens-coupled detector system, dedicated for radiography and tomography. Based on our results we discuss the strengths and weaknesses of the different imaging setups for paleontological studies.
A forward planned treatment planning technique for non-small-cell lung cancer stereotactic ablative body radiotherapy based on a systematic review of literature
Authors: Marchant Anne C. , Macwan Sheela M. 
Published: August 2015

AbstractPurpose and MethodA systematic literature review of six computerised databases was undertaken in order to review and summarise a forward planned lung stereotactic ablative body radiotherapy (SABR) treatment planning (TP) technique as a starting point for clinical implementation in the author’s department based on current empirical research. The data were abstracted and content analysed to synthesise the findings based upon a SIGN quality checklist tool.FindingsA four-dimensional computed tomography scan should be performed upon which the internal target volume and organs at risk (OAR) are drawn. A set-up margin of 5 mm is applied to account for inter-fraction motion. The field arrangement consists of a combination of 7–13 coplanar and non-coplanar beams all evenly spaced. Beam modifiers are used to assist in the homogeneity of the beam, although a 20% planning target volume dose homogeneity is acceptable. The recommended fractionations by the UK SABR Consortium are 54 Gy in 3 fractions (standard), 55–60 Gy in 5 fractions (conservative) and 50–60 Gy in 8–10 fractions (very conservative). Conformity indices for both the target volume and OAR will be used to assess the planned distribution.ConclusionAn overview of a clinically acceptable forward planned lung SABR TP technique based on current literature as a starting point, with a view to inverse planning with support from the UK SABR Consortium mentoring scheme.
To determine the source dwell positions of HDR brachytherapy using 2D 729 ion chamber array
Authors: Syam Kumar S. A. , Gangadharan Sitha P. , Cheruparambil Aswathi P. , Parakat Anjana T. , Perumangat Aparna 
Published: August 2015

AbstractThe purpose of this study was to determine the dwell position of a high-dose-rate (HDR) brachytherapy Ir-192 source using a PTW Seven29 2D detector array. A Nucletron Microselectron HDR device and 2D array ionisation chamber, equipped with 729 ionisation chambers uniformly arranged in a 27×27 matrix with an active array area of 27×27 cm2, were used for this study. Different dwell positions were assigned in the HDR machine. Rigid interstitial needles and a vaginal applicator were positioned on the 2D array, which was then exposed according to the programmed dwell positions. Subsequently, the positional accuracy of the source position was analysed. This process was repeated for different dwell positions. The results were analysed using an in-house-developed Excel programme. Different random dwell position checks as well as dwell position measurements were performed using a radiochromic film. The dwell positions measured by the 2D array were found to be in good agreement with those measured by the film. The standard deviations between the doses obtained from the different dwell positions were 0·191828, 0·329973, 0·370632 and 0·779939, whereas the corresponding standard deviations of the doses at the vaginal cylinder were 0·60303, 0·242808, 0·242808 and 0·065309. When the planned and measured dwell positions were plotted, a linear relationship was obtained.
Ideas or institutions? – a comment
Authors: TABELLINI GUIDO 
Published: August 2015

AbstractDeirdre McCloskey is right, economists interested in comparative development ought to pay more attention to the history of ideas. But, which ideas? And how do they emerge? In this short paper I argue that other ideas, besides the bourgeois ethics, are at least as important. And that a new emphasis on ideas does not make institutions less important, nor does it require that we abandon the traditional method of economics.
Diagnosis-specific CBT as a stepping stone to transdiagnostic CBT in a complex case
Authors: Cowles Megan , Nightingale Jim 
Published: August 2015

AbstractComorbid anxiety and mood disorders are common but the majority of treatments tend to focus on a particular diagnosis. Previous research has found that cognitive behavioural therapy (CBT) targeted at a specific diagnosis can lead to improvements in comorbidities, especially in the case of CBT for panic. However, there is an emerging evidence base that transdiagnostic CBT, which addresses common underlying processes across presenting problems, may be effective at treating comorbidities simultaneously. Given the simple nature of the cognitive formulation of panic it is arguable that a panic-specific CBT intervention could help socialize patients to CBT before progressing to a transdiagnostic approach. This paper uses a single-case experimental design to illustrate an example of using diagnosis-specific CBT as a springboard to transdiagnostic CBT with a patient presenting with panic and agoraphobia, social anxiety, depression, uncontrollable worry, suicidality, self-harming behaviours and a history of bulimia. Results suggest that this was a well-received and effective intervention. Clinical implications are discussed as well as limitations and directions for future research
A Human Rights-based Approach to Disaster Displacement in the Asia-Pacific
Authors: LEWIS Bridget , MAGUIRE Rowena 
Published: August 2015

AbstractThis paper analyzes the application of rights-based approaches to disaster displacement in the Asia-Pacific region in order to assess whether the current framework is sufficient to protect the rights of internally displaced persons. It identifies that disaster-induced displacement is increasingly prevalent in the region and that economic and social conditions in many countries mean that the impact of displacement is often prolonged and more severe. The paper identifies the relevant human rights principles which apply in the context of disaster-induced displacement and examines their implementation in a number of soft-law instruments. While it identifies shortcomings in implementation and enforcement, the paper concludes that a rights-based approach could be enhanced by greater engagement with existing human rights treaties and greater implementation of soft-law principles, and that no new instrument is required.
A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity
Authors: Conde-Perez Alejandro , Gros Gwendoline , Longvert Christine , Pedersen Malin , Petit Valérie , Aktary Zackie , Viros Amaya , Gesbert Franck , Delmas Véronique , Rambow Florian , Bastian Boris C. , Campbell Andrew D. , Colombo Sophie , Puig Isabel , Bellacosa Alfonso , Sansom Owen , Marais Richard , Van Kempen Leon C. L. T. , Larue Lionel 
Published: August 2015

AbstractLoss of the tumour suppressor PTEN is frequent in human melanoma, results in MAPK activation, suppresses senescence and mediates metastatic behaviour. How PTEN loss mediates these effects is unknown. Here we show that loss of PTEN in epithelial and melanocytic cell lines induces the nuclear localization and transcriptional activation of β-catenin independent of the PI3K–AKT–GSK3β axis. The absence of PTEN leads to caveolin-1 (CAV1)-dependent β-catenin transcriptional modulation in vitro, cooperates with NRASQ61K to initiate melanomagenesis in vivo and induces efficient metastasis formation associated with E-cadherin internalization. The CAV1-β–catenin axis is mediated by a feedback loop in which β-catenin represses transcription of miR-199a-5p and miR-203, which suppress the levels of CAV1 mRNA in melanoma cells. These data reveal a mechanism by which loss of PTEN increases CAV1-mediated dissociation of β-catenin from membranous E-cadherin, which may promote senescence bypass and metastasis.
Nanomicelle formulation for topical delivery of cyclosporine A into the cornea: in vitro mechanism and in vivo permeation evaluation
Authors: Guo Chuanlong , Zhang Yan , Yang Zhao , Li Mengshuang , Li Fengjie , Cui Fenghua , Liu Ting , Shi Weiyun , Wu Xianggen 
Published: August 2015

AbstractA stable topical ophthalmic cyclosporine A (CsA) formulation with good tolerance and high efficacy is still a desire in pharmaceutics and clinics. This article describes the preparation of CsA containing nanomicelles using a polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol (PVCL-PVA-PEG) graft copolymer. Both the polymer itself and the CsA nanomicelles were evaluated for cytotoxicity and ocular irritation. The in vitro uptake and intracellular fate of nanomicelles were characterized. In vivo cornea permeation test performed with 0.5 mg/mL CsA containing nanomicelles and compared with a commercially available CsA (10 mg/mL) oil-based ophthalmic solution. The CsA nanomicelle ophthalmic solution was simple to prepare and remained storage stable. PVCL-PVA-PEG had no cytotoxicity as its monomer solution and as its micelle solution (IC50(48 h) = 14.02 mg/mL). CsA nanomicelles also had excellent ocular tolerance in rabbits. The use of nanomicelles significantly improved in vitro cellular uptake, apparently by an energy dependent intracellular endocytosis pathway that involved early endosomes, late endosomes, lysosomes and ER. In vivo permeation showed that 0.5 mg/mL CsA nanomicelles delivered high levels of CsA into the cornea, when compared to the oil-based 10 mg/mL CsA ophthalmic solution. These findings indicated PVCL-PVA-PEG nanomicelles could be a promising topical delivery system for ocular administration of CsA.
Edge state magnetism in zigzag-interfaced graphene via spin susceptibility measurements
Authors: Makarova T. L. , Shelankov A. L. , Zyrianova A. A. , Veinger A. I. , Tisnek T. V. , Lähderanta E. , Shames A. I. , Okotrub A. V. , Bulusheva L. G. , Chekhova G. N. , Pinakov D. V. , Asanov I. P. , Šljivančanin Ž. 
Published: August 2015

AbstractDevelopment of graphene spintronic devices relies on transforming it into a material with a spin order. Attempts to make graphene magnetic by introducing zigzag edge states have failed due to energetically unstable structure of torn zigzag edges. Here, we report on the formation of nanoridges, i.e., stable crystallographically oriented fluorine monoatomic chains and provide experimental evidence for strongly coupled magnetic states at the graphene-fluorographene interfaces. From the first principle calculations, the spins at the localized edge states are ferromagnetically ordered within each of the zigzag interface whereas the spin interaction across a nanoridge is antiferromagnetic. Magnetic susceptibility data agree with this physical picture and exhibit behaviour typical of quantum spin-ladder system with ferromagnetic legs and antiferromagnetic rungs. The exchange coupling constant along the rungs is measured to be 450 K. The coupling is strong enough to consider graphene with fluorine nanoridges as a candidate for a room temperature spintronics material.
Neural stem/progenitor cell properties of glial cells in the adult mouse auditory nerve
Authors: Lang Hainan , Xing Yazhi , Brown LaShardai N. , Samuvel Devadoss J. , Panganiban Clarisse H. , Havens Luke T. , Balasubramanian Sundaravadivel , Wegner Michael , Krug Edward L. , Barth Jeremy L. 
Published: August 2015

AbstractThe auditory nerve is the primary conveyor of hearing information from sensory hair cells to the brain. It has been believed that loss of the auditory nerve is irreversible in the adult mammalian ear, resulting in sensorineural hearing loss. We examined the regenerative potential of the auditory nerve in a mouse model of auditory neuropathy. Following neuronal degeneration, quiescent glial cells converted to an activated state showing a decrease in nuclear chromatin condensation, altered histone deacetylase expression and up-regulation of numerous genes associated with neurogenesis or development. Neurosphere formation assays showed that adult auditory nerves contain neural stem/progenitor cells (NSPs) that were within a Sox2-positive glial population. Production of neurospheres from auditory nerve cells was stimulated by acute neuronal injury and hypoxic conditioning. These results demonstrate that a subset of glial cells in the adult auditory nerve exhibit several characteristics of NSPs and are therefore potential targets for promoting auditory nerve regeneration.
Changes in weight-at-length and size-at-age of mature Northeast Atlantic mackerel (Scomber scombrus) from 1984 to 2013: effects of mackerel stock size and herring (Clupea harengus) stock size
Authors: Olafsdottir Anna H. , Slotte Aril , Jacobsen Jan Arge , Oskarsson Guðmundur J. , Utne Kjell R. , Nøttestad Leif 
Published: August 2015

AbstractWeight-at-length and length-/weight-at-age were analysed for mature 3- to 8-year-old Northeast Atlantic mackerel (Scomber scombrus; n= 26 084) collected annually in autumn (September and October) at the end of the annual feeding season during 1984–2013 in the northern North Sea. The age range represented 92% of the mackerel stock size (age 3+). During the most recent decade, mackerel length- and weight-at-age continually declined. In 2013, the average mackerel was 3.7 cm shorter and weighed 175 g less than the average individual in 2002. Individual weight-at-length, demonstrating annual summer feeding success, continually declined during the most recent 5 years, whereas somatic growth of cohorts aged 3–8 continually declined for the last 11 of 25 cohorts investigated. Growth of the latest cohort was 34% of the maximum cohort growth recorded. Both weight-at-length and cohort growth were negatively affected by mackerel stock size and Norwegian spring-spawning herring (Clupea harengus) stock size (weight-at-length: r2 = 0.89; growth (length): r2 = 0.68; growth (weight): r2 = 0.78), while temperature was not significant. Conspecific density-dependence was most likely mediated via intensified competition associated with greater mackerel density. Negative effects of herring were likely mediated by exploitative competition for shared food resources rather than direct competition due to limited spatio-temporal overlap between mackerel and herring during the feeding season. Herring begin their seasonal feeding migration at least a month before mackerel; therefore, herring consumption influences prey availability for the later-arriving mackerel. Record low mackerel growth and negative effects of mackerel and herring stock size suggest that the carrying capacity of the Norwegian Sea and adjacent areas for plankton-feeding fish stocks have been reached. However, compounding effects of a less productive Norwegian Sea during the 30-year period cannot be excluded.
Group 2 innate lymphoid cells in disease
Authors: Halim Timotheus Y. F. 
Published: August 2015

Abstract
Group 2 innate lymphoid cells (ILC2) are now recognized as an important innate source of type-2 effector cytokines. Although initially associated with mucosal tissues, it is clear that ILC2 are present in diverse anatomical locations. The function of ILC2 at these sites is equally varied, and although ILC2 represent a relatively minor population, they are fundamentally important regulators of innate and adaptive immune processes. As such, there is much interest to understand the role of ILC2 in diseases with a type-2 inflammatory component. This review explores the known roles of ILC2 in disease, and the diseases that show associations or other strong evidence for the involvement of ILC2.
The Swedish specialist examination in emergency medicine: form and function
Authors: Dryver Eric T. , Eriksson Anders , Söderberg Patrik , Kurland Lisa 
Published: August 2015

Aim/Background
The purpose of the Swedish specialist examination in Emergency Medicine is not only to determine whether residents have attained the level of competence of specialists, but also to guide and facilitate residency training.

Methods
The Swedish Society for Emergency Medicine has developed checklists that delineate criteria of consideration and action items for particular processes. These checklists are freely available and used to assess competence during the examination. They are also intended for use during teaching and clinical care, thus promoting alignment between clinical practice, teaching and assessment. The examination is carried out locally by residency program educators, thereby obviating travel expenses. It consists of a total of 24 stations and over 100 potential scenarios, thereby minimizing case specificity. Each station consists of a scenario based on a real case. The checklists allow for direct feedback to the examinee after each station.

Results and Conclusion
This model may be of interest to other European countries.
The BM2 protein of influenza B virus is synthesized in the late phase of infection and incorporated into virions as a subviral component
Authors: Odagiri Takato , Hong Jin , Ohara Yoshiro 
Published: August 2015

The influenza B virus genome RNA segment 7 encodes the M1 and BM2 proteins. The BM2 protein is synthesized by a coupled translational termination–reinitiation mechanism at the overlapping stop–start pentanucleotide in a bicistronic mRNA transcribed from RNA segment 7. However, features and functions of this protein remain unclear. In this study the BM2 protein was characterized by using an antiserum raised to the BM2 protein of influenza virus strain B/Yamagata/1/73. In cells infected with B/Yamagata virus the αBM2 antibody specifically detected the BM2 protein with a molecular mass of 12 kDa and also a polypeptide with a molecular mass of 17 kDa. When infected cells were labelled with32Piand immunoprecipitated with the αBM2 antibody, the32P-labelled 17 kDa polypeptide was specifically precipitated. In the presence of casein kinase inhibitor CKI-7 the synthesis of the 17 kDa and BM2 proteins was completely suppressed, although other viral proteins, except for the polymerase protein, were synthesized normally. These results suggest that the 17 kDa species is a phosphorylated form of the BM2 protein. These species were substantially synthesized in the late phase of infection and localized in the cytoplasm throughout infection. Moreover, they were transported to the plasma membrane and thereafter were incorporated into virions. These results therefore suggest that the BM2 and the 17 kDa proteins are necessary for the life-cycle of influenza B virus.
The RNA-dependent RNA polymerases of different members of the family Flaviviridae exhibit similar properties in vitro
Authors: Steffens Sabine , Thiel Heinz-Jürgen , Behrens Sven-Erik 
Published: August 2015

The virus-encoded RNA-dependent RNA polymerase (RdRp), which is required for replication of the positive-strand RNA genome, is a key enzyme of members of the virus familyFlaviviridae. By using heterologously expressed proteins, we demonstrate that the 77 kDa NS5B protein of two pestiviruses, bovine viral diarrhoea virus and classical swine fever virus, and the 100 kDa NS5 protein of the West Nile flavivirus possess RdRp activityin vitro. As originally shown for the RdRp of hepatitis C virus, RNA synthesis catalysed by the pestivirus and flavivirus enzymes is strictly primer- dependentin vitro. Accordingly, initiation of RNA polymerization on homopolymeric RNAs and heteropolymeric templates, the latter with a blocked 3′-hydroxyl group, was found to be dependent on the presence of complementary oligonucleotide primer molecules. On unblocked heteropolymeric templates, including authentic viral RNAs, the RdRps were shown to initiate RNA synthesis via intramolecular priming at the 3′-hydroxyl group of the template and ‘copy-back’ transcription, thus yielding RNase- resistant hairpin molecules. Taken together, the RdRps of different members of theFlaviviridaewere demonstrated to exhibit a common reactivity profilein vitro, typical of nucleic acid- polymerizing enzymes.