bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’emploi d’un modèle d’enseignement systématique d’écriture: Une étude de cas en 7eannée de l’immersion précoce
Authors: Bouthillier Josée Le , Dicks Joseph 
Published: July 2013

Résumé:Cette étude de cas examine le développement en écriture d’élèves en immersion française précoce par rapport à un texte d’opinion. L’enseignante a adopté un modèle systématique de l’enseignement de l’écriture qui incorporait les pratiques exemplaires en écriture, les éléments d’un bon texte selon le genre, le processus de l’écrit et l’approche du contrepoids linguistique. Vingt-sept élèves d’une classe d’immersion précoce de la 7eannée et leur enseignante ont participé à l’étude. Ces élèves ont écrit un texte initial ainsi qu’un deuxième texte après l’unité d’enseignement sur le texte d’opinion intégrant le modèle systématique. Le texte initial des élèves et leur deuxième texte ont été analysés selon une grille d’appréciation incorporant les six éléments d’un bon texte. L’analyse de ces textes s’est faite selon le pourcentage d’élèves qui ont mieux réussi le deuxième texte globalement et pour chacun des traits. Cette analyse a servi de données quantitatives. Ces textes ont aussi été analysés de façon qualitative et des observations en salle de classe durant le processus de l’écrit se sont ajoutées aux données qualitatives. Les résultats semblent indiquer que ce modèle d’écriture a été efficace pour l’apprentissage des élèves puisque 23/27 élèves (85%) ont mieux réussi sur au moins un élément d’écriture et presque 30% sur tous les éléments identifiés d’un bon texte. Des analyses qualitatives d’exemples spécifiques appuient ces chiffres. En plus, l’approche du contrepoids semble s’appliquer au développement de la compétence textuelle.
Travail du héros
Authors: Aubray Marie-Christine , Agostini Dominique 
Published: July 2013

Pour questionner les liens entre travail d’adolescence et travail du héros, les auteurs font se rencontrer un héros mythique Héraclès et le héros adolescent Arkadi de Dostoïevski. Devient héros, l’adolescent qui sortira vainqueur des épreuves du pubertaire, pour s’engager dans le processus adolescens. Ce passage impliquant la rencontre de deux apories : parricide/infanticide et mortalité/immortalité.
Du héros tragique au héros ordinaire
Authors: Bonnet Gérard 
Published: July 2013

Homère privilégie deux types de héros : celui d’Achille dans l’ Iliade , qui magnifie le combat à mort et a fait bien des émules au cours de l’histoire, et puis celui qu’incarne Ulysse dans l’ Odyssée où le héros s’illustre en déjouant les obstacles qu’il rencontre sur la route du retour vers son lieu d’origine. D’un côté nous avons une lutte duelle qui certes entraîne la notoriété, mais provoque la destruction de l’une des deux parties en présence, et de l’autre, un combat de tous les instants du héros pour sauver sa vie et retrouver sa place dans la cité. Le premier privilégie le regard et se soumet aux exigences du paraître, le second au contraire s’en prend d’abord à l’œil qui le domine et en démonte les rouages pour se donner un nom. Le processus adolescent participe de ces deux parcours à la fois, et suppose le dégagement progressif de l’emprise du voir qui fait miroiter l’idéal. En se référant à diverses œuvres littéraires, l’auteur montre à quelles conditions cette évolution est possible.
Constructions du héros à l'adolescence
Authors: Monniello Gianluigi 
Published: July 2013

Deux définitions significatives de L. Arioste et de B. Fioretti sont utilisées par l’auteur pour décrire d’abord , le besoin naturel de construire , au niveau imaginaire, la figure du héros en tant que contribution possible au fonctionnement psychique adolescent et en tant que référent adéquat imaginaire pour se créer et pour créer sa propre ars vivendi ; ensuite , pour souligner que la rencontre avec l’adolescent implique aussi la présence en lui de quelque chose qui va au-delà du processus naturel de construction , inhérent au développement et du jouer à faire le héros de l’enfance. L’auteur décrit trois possibles forces co-existantes vers l’héroïsme, avec des résultats très différents, qui s’ouvrent aux adolescents. La première poussée , réactive, est celle de continuer courageusement la recherche et la reconquête des valeurs du passé ; la deuxième poussée , positive et différenciatrice, invite l’adolescent à se détacher des mondes qui l’ont engendré et de leurs influences internes et externes ; la troisième , créative, est celle-là qui le rend fidèle à ses expériences sensorielles originaires en le poussant, inconsciemment, « à faire ce qu’il peut ».
Héros et adolescents
Authors: Carbone Paola 
Published: July 2013

Cet article tente de répondre à deux questions : qui est « le héros » ? et quel est le rapport de la question héroïque avec l’adolescence ? Pour rencontrer les héros dans leur essence originaire, l’auteur retourne à l’ Iliade et l’ Odyssée , et repère certaines caractéristiques fondamentales qui identifient profondément la mission héroïque à celle de l’adolescence. Les deux poèmes organisés autour des dimensions narratives du siège et du voyage représentent assez bien les lignes de force le long desquelles se décline l’expérience adolescente. Le fil rouge de l’exposé se noue autour de quatre thèmes articulés en couples dialectiques : la Préhistoire et l’Histoire, l’Unique et le Double, le Cercle et l’Ellipse, la Vie et la Mort. Le mythe du héros – dans cette perspective – est le moyen grâce auquel il est possible de tenter une confrontation laïque avec la mort, confrontation qui paradoxalement représente un des points cardinaux du processus adolescent.
De Hector à Énée, via Achille
Authors: Baldini Tito 
Published: July 2013

L’analyste qui accompagne l’adolescent dans son parcours vers l’âge adulte, s’identifie dans le transfert à une sorte de « Hector » et vit le parcours analytique de son patient comme une transfiguration de son être « Achille » vers son devenir « Énée », seul héros qui accède à un âge adulte satisfaisant. Le recours aux textes de l’Antiquité et aux figures mythologiques du héros offre en effet des supports et représentations utiles au travail avec les adolescents, notamment en permettant de faire évoluer le transfert et le contre-transfert.
Temporalités autistique, adolescente et virtuelle : à la croisée de trois mondes
Authors: Aubertin Solène , Haza Marion 
Published: July 2013

Le virtuel est souvent décrié comme un nouvel objet d’addiction pour les adolescents. Nous aborderons ici le point de vue selon lequel cet outil favoriserait l’élaboration de la capacité dépressive avant une mise en « Je » dans le réel. Écran et corps du sujet, l’ordinateur serait un premier lieu de symbolisation afin d’accéder à une véritable subjectivation. Amenant dans un autre espace et dans un autre temps, le virtuel permettrait d’aborder autrement la question de la temporalité relative à la problématique de la perte. La perte de l’objet engendrant l’avènement du « Je », de quelle manière le virtuel peut être un nouveau lieu d’appropriation de l’absence ? Comment peut-il permettre le passage d’une intemporalité à une atemporalité ? Cette idée sera éclairée par le cas d’un jeune autiste comme archétype de la question de la perte ainsi que de celle du passage de l’imaginaire au réel.
Homère et le tennis, le foot, la musique
Authors: de Azambuja Miguel 
Published: July 2013

Roger Federer, Rafael Nadal, deux héros antinomiques, aux qualités contraires. L’un est elfique, l’autre est massif, l’un est élégance, l’autre est tellurique. Lointains descendants d’Ulysse et d’Achille, les héros marchent souvent par deux, à la fois indissociables et complémentaires. La psyché aurait-elle besoin d’une telle bipartition ?
Plasma B Lymphocyte Stimulator and B Cell Differentiation in Idiopathic Pulmonary Fibrosis Patients
Authors: Xue Jianmin , Kass Daniel J. , Bon Jessica , Vuga Louis , Tan Jiangning , Csizmadia Eva , Otterbein Leo , Soejima Makoto , Levesque Marc C. , Gibson Kevin F. , Kaminski Naftali , Pilewski Joseph M. , Donahoe Michael , Sciurba Frank C. , Duncan Steven R. 
Published: July 2013

Abstract
We hypothesized B cells are involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a progressive, restrictive lung disease that is refractory to glucocorticoids and other nonspecific therapies, and almost invariably lethal. Accordingly, we sought to identify clinically associated B cell–related abnormalities in these patients. Phenotypes of circulating B cells were characterized by flow cytometry. Intrapulmonary processes were evaluated by immunohistochemistry. Plasma B lymphocyte stimulating factor (BLyS) was assayed by ELISA. Circulating B cells of IPF subjects were more Ag differentiated, with greater plasmablast proportions (3.1 ± 0.8%) than in normal controls (1.3 ± 0.3%) (p &lt; 0.03), and the extent of this differentiation correlated with IPF patient lung volumes (r = 0.44, p &lt; 0.03). CD20+ B cell aggregates, diffuse parenchymal and perivascular immune complexes, and complement depositions were all prevalent in IPF lungs, but much less prominent or absent in normal lungs. Plasma concentrations of BLyS, an obligate factor for B cell survival and differentiation, were significantly greater (p &lt; 0.0001) in 110 IPF (2.05 ± 0.05 ng/ml) than among 53 normal (1.40 ± 0.04 ng/ml) and 90 chronic obstructive pulmonary disease subjects (1.59 ± 0.05 ng/ml). BLyS levels were uniquely correlated among IPF patients with pulmonary artery pressures (r = 0.58, p &lt; 0.0001). The 25% of IPF subjects with the greatest BLyS values also had diminished 1-y survival (46 ± 11%), compared with those with lesser BLyS concentrations (81 ± 5%) (hazard ratio = 4.0, 95% confidence interval = 1.8–8.7, p = 0.0002). Abnormalities of B cells and BLyS are common in IPF patients, and highly associated with disease manifestations and patient outcomes. These findings have implications regarding IPF pathogenesis and illuminate the potential for novel treatment regimens that specifically target B cells in patients with this lung disease.
Tick-Borne Encephalitis (TBE) and Hepatitis B Nonresponders Feature Different Immunologic Mechanisms in Response to TBE and Influenza Vaccination with Involvement of Regulatory T and B Cells and IL-10
Authors: Garner-Spitzer Erika , Wagner Angelika , Paulke-Korinek Maria , Kollaritsch Herwig , Heinz Franz X. , Redlberger-Fritz Monika , Stiasny Karin , Fischer Gottfried F. , Kundi Michael , Wiedermann Ursula 
Published: July 2013

Abstract
Low responsiveness/nonresponsiveness is characterized by an insufficient immune response upon primary and/or booster vaccination and affects 1–10% of vaccinees. In the current study, we aimed to investigate whether nonresponsiveness is an Ag/vaccine-specific phenomenon and to clarify underlying immunological mechanisms. Nonresponders to tick-borne encephalitis (TBE) or hepatitis B Ag with a history of previous TBE vaccinations were booster vaccinated with TBE and influenza vaccine and compared with TBE high responders in terms of humoral and cellular immune response. Postboosters in TBE high responder existing TBE titers increased, and solid humoral responses to influenza vaccine were induced. In TBE nonresponders, low to undetectable prevaccination TBE titers remained low, whereas sufficient influenza Abs were induced. In both TBE groups, a positive correlation of humoral and cellular immune response was seen as high/low TBE titers were associated with sufficient/lack of Ag-specific T cell proliferation. Furthermore, responses to influenza were robust in terms of Abs and cytokine production. In contrast, in hepatitis B nonresponders, sufficient humoral responses to TBE and influenza Ags were induced despite lacking specific IL-2 and IFN-γ production. Importantly, these patients showed high IL-10 baseline levels in vitro. HLA-DR subtypes associated with hepatitis B nonresponsiveness were overrepresented in this group, and high IL-10 levels were linked to these subtypes. Whereas TBE and hepatitis B nonresponders had increased IL-10–producing FOXP3+ T regulatory cells upon vaccination, only in hepatitis B nonresponders, showing elevated prevaccination IL-10 levels, a prominent population of B regulatory cells was detected. We conclude that immunological pathways of nonresponsiveness follow different patterns depending both on vaccine Ag and genetic predisposition of the vaccinee.
YB-1 Is an Early and Central Mediator of Bacterial and Sterile Inflammation In Vivo
Authors: Hanssen Lydia , Alidousty Christina , Djudjaj Sonja , Frye Björn C. , Rauen Thomas , Boor Peter , Mertens Peter R. , van Roeyen Claudia R. , Tacke Frank , Heymann Felix , Tittel Andre P. , Koch Alexander , Floege Jürgen , Ostendorf Tammo , Raffetseder Ute 
Published: July 2013

Abstract
In vitro studies identified Y-box–binding protein (YB)-1 as a key regulator of inflammatory mediators. In this study, we observed increased levels of secreted YB-1 in sera from sepsis patients. This led us to investigate the in vivo role of YB-1 in murine models of acute peritonitis following LPS injection, in sterile renal inflammation following unilateral ureteral obstruction, and in experimental pyelonephritis. LPS injection enhanced de novo secretion of YB-1 into the urine and the peritoneal fluid of LPS-treated mice. Furthermore, we could demonstrate a significant, transient upregulation and posttranslational modification (phosphorylation at serine 102) of YB-1 in renal and inflammatory cells. Increased renal cytoplasmic YB-1 amounts conferred enhanced expression of proinflammatory chemokines CCL2 and CCL5. Along these lines, heterozygous YB-1 knockout mice (YB-1+/d) that display 50% reduced YB-1 levels developed significantly lower responses to both LPS and sterile inflammation induced by unilateral ureteral obstruction. This included diminished immune cell numbers due to impaired migration propensities and reduced chemokine expression. YB-1+/d mice were protected from LPS-associated mortality (20% mortality on day 3 versus 80% in wild-type controls); however, immunosuppression in YB-1+/d animals resulted in 50% mortality. In conclusion, our findings identify YB-1 as a major, nonredundant mediator in both systemic and local inflammatory responses.
Identification of the Tetraspanin CD82 as a New Barrier to Xenotransplantation
Authors: Saleh Soad M. , Parhar Ranjit S. , Al-Hejailan Reem S. , Bakheet Razan H. , Khaleel Hala S. , Khalak Hanif G. , Halees Anason S. , Zaidi Marya Z. , Meyer Brian F. , Yung Gisella P. , Seebach Jörg D. , Conca Walter , Khabar Khalid S. , Collison Kate S. , Al-Mohanna Futwan A. 
Published: July 2013

AbstractSignificant immunological obstacles are to be negotiated before xenotransplantation becomes a clinical reality. An initial rejection of transplanted vascularized xenograft is attributed to Galα1,3Galβ1,4GlcNAc-R (Galα1,3-Gal)–dependent and –independent mechanisms. Hitherto, no receptor molecule has been identified that could account for Galα1,3-Gal–independent rejection. In this study, we identify the tetraspanin CD82 as a receptor molecule for the Galα1,3-Gal–independent mechanism. We demonstrate that, in contrast to human undifferentiated myeloid cell lines, differentiated cell lines are capable of recognizing xenogeneic porcine aortic endothelial cells in a calcium-dependent manner. Transcriptome-wide analysis to identify the differentially expressed transcripts in these cells revealed that the most likely candidate of the Galα1,3-Gal–independent recognition moiety is the tetraspanin CD82. Abs to CD82 inhibited the calcium response and the subsequent activation invoked by xenogeneic encounter. Our data identify CD82 on innate immune cells as a major “xenogenicity sensor” and open new avenues of intervention to making xenotransplantation a clinical reality.
Vinculin Arrests Motile B Cells by Stabilizing Integrin Clustering at the Immune Synapse
Authors: Saez de Guinoa Julia , Barrio Laura , Carrasco Yolanda R. 
Published: July 2013

Abstract
Lymphocytes use integrin-based platforms to move and adhere firmly to the surface of other cells. The molecular mechanisms governing lymphocyte adhesion dynamics are however poorly understood. In this study, we show that in mouse B lymphocytes, the actin binding protein vinculin localizes to the ring-shaped integrin-rich domain of the immune synapse (IS); the assembly of this platform, triggered by cognate immune interactions, is needed for chemokine-mediated B cell motility arrest and leads to firm, long-lasting B cell adhesion to the APC. Vinculin is recruited early in IS formation, in parallel to a local phosphatidylinositol (4,5)-bisphosphate wave, and requires spleen tyrosine kinase activity. Lack of vinculin at the IS impairs firm adhesion, promoting, in turn, cell migration with Ag clustered at the uropod. Vinculin localization to the B cell contact area depends on actomyosin. These results identify vinculin as a major controller of integrin-mediated adhesion dynamics in B cells.
Three types of interviews: Qualitative research methods in social health
Authors: Stuckey Heather 
Published: July 2013

AbstractInterviewing is a primary way of collecting data in qualitative research to direct the participant in responding to a specific research question. In diabetes, this may include “what are the reasons that have contributed to your success in diabetes self-management” or “how do you believe stress impacts your blood glucose?” Three types of interviews are common in social health: (1) Structured; (2) semi-structured; and (3) narrative interview. These range in a format including specified sets of questions to the telling of patient stories in an organic way. This paper describes the differences between these types of interviews and examples of each related to diabetes research.
Impact of socio-cultural factors, dietary habits, and lifestyle patterns on the health status of North African migrants in France
Authors: Kamoun Mahdi , Mnif Mouna , Charfi Nadia , Naceur Basma , Mnif Fatma , Rekik Nabila , Abid Mohamed 
Published: July 2013

AbstractThe available studies in France showed a paradox among North African migrant men in France and some other developed countries, i.e., that migration could have a protective effect against some nutrition-related noncommunicable diseases compared to French. The origin of this paradox is not well documented. Particular attention was given to the influence of socio-cultural and environmental factors on health status of North African migrants. Conservation of healthy diet habits, lower prevalence of smoking, lower alcohol consumption, and adoption of a more active lifestyle may confer protective effects on morbidity and mortality of North African men compared to local-born French. It should be noted however that beneficial effects of migration in men would be expected to decrease with the length of stay in the host country because of acculturation to the host country lifestyle. More comprehensive and larger-scale studies will be required to provide a better insight into migration-health relationships.
Diabetes in the Himalayas: Psychosocial barriers and solutions
Authors: Poudel Resham , Adhikari Bishwa 
Published: July 2013

AbstractPsychosocial problems are common in diabetic population. Apart from the common issues faced by the diabetics everywhere, the Himalayan population suffer unique psychosocial burden arising out of poor social infrastructures, low economy and education, and extreme bio-geographical disadvantages. The patients are deprived of modern state-of-art scientific health care and mostly depend on conventional medicine. Stress, hostility, and depression emerging out of this misery affect the health of diabetics through modified behaviors, lifestyles, and psychology. Studies have demonstrated that addressing psychosocial issues is unequivocally associated with better outcomes in diabetes management. The psychosocial support and education highlighted by the DAWN study can be rightly adopted to solve the psychosocial problems and improve the daily life of the diabetic people in general as well as in the Himalayas.
Psycho-social and clinical aspects of diabeto-criticare
Authors: Bajwa Sukhminder , Sehgal Vishal 
Published: July 2013

AbstractA progressive rise in the number of diabetes mellitus (DM) patients has been observed globally with India becoming a new diabetic capital. In spite of numerous advancements in the pharmacotherapeutics, diabetes is still difficult to manage and control. Besides clinical management of DM, an increasing need is felt to manage the psycho-social aspects related to DM, which have not been given adequate attention. Similar trends can be observed in the critically ill diabetic patients in intensive care units (ICU), which is treated on the lines of evidence based clinical medicine. The psycho-social management of diabetes is somewhat a newer concept for the intensivist that was being practiced occasionally, but unknowingly. The newer psycho-social guidelines to manage DM can be of immense help in ICU if such guidelines are modified to suit the needs of the intensivists and critically ill patients. The current review is aimed at analyzing the clinical, biological, social and psychological aspects of critically ill DM patients and the possible therapeutics measures and modifications in the current regimens so as to effectively treat the rising epidemic of DM.
Children with diabetes friendly services: A blueprint
Authors: Kalra Sanjay , John Mathew , Unnikrishnan Ambika , Sahay Rakesh , Baruah Manash , Bantwal Ganapathy 
Published: July 2013

AbstractChildren with diabetes, despite their small numbers, form a population with needs different from adult subjects with diabetes. This emphasizes the need to establish child- friendly standards in services rendered to these children. The care providers for children with diabetes are quite heterogeneous and include generalists, paediatric subspecialist and endocrinologists and care is delivered in various circumstances. Various aspects of caring for children need to be taken into account when a system is created for children with diabetes. This includes but is not limited to physical infrastructure of the system, qualified medical personal with experience in handling children and quality systems to maintain cold chains for insulin and laboratory reporting. The system should be able to reach out to other stake holders that include the community and family of children with diabetes. The system should be subjected to self audit, and performance on various key indicators should be assessed.
Preparation and readability assessment of patient information leaflets for diabetic foot ulcers
Authors: Roy Raymol , Sekhar M. , Rodrigues Gabriel , Rajesh V. 
Published: July 2013

AbstractContext: Patient counseling is the mainstay for prevention and management of diabetic foot ulcer. Hence, patient information leaflet (PIL) can act as an educational material for imparting patient education regarding diabetic foot care for better patient outcome.Aim: The objective of this study was to develop and to assess the readability of PIL for diabetic foot ulcer.Materials and Methods: Various online resources such as Patient UK and Micromedex data base were used to prepare PILs on diabetic foot ulcer. Physicians were validated the content of the leaflet. Leaflet was designed and modified according to the physician's suggestions. PILs-readability was checked online by using the website www.readability-score.com and calculated Flesch Reading Ease (FRE) and Flesch-Kincaid grade level (FK-GL). Layout and design features of the PILs were assessed by using Baker Able Leaflets Design (BALD) method.Results: Readability of the leaflet was assessed by using the FRE and FK-GL scores. After initial assessment leaflets were modified to achieve ideal readability scores. The best FRE score achieved was 69.9 and FK-GL score achieved was 7.1. The BALD score was 27.Conclusions: PILs prepared had ideal readability score and layout design. The leaflet's estimated FRE and FK-GL scores rate showed that it was fairly easy readable.