bluuebunny/crossref_metadata_2025_split huggingface dataset:
MRI‐based prediction of pulsed high‐intensity focused ultrasound effect on tissue transport in rabbit muscle
Authors: O'Neill Brian E. , Vo Howard Q. , Shao Hongwei , Karmonik Christof , Zhou Xiaobo , Li King C. 
Published: April 2013

PurposeTo design an algorithm for optimizing pulsed high intensity focused ultrasound (p‐HIFU) treatment parameters to maximize tissue transport while minimizing thermal necrosis based on MR image guidance.Materials and MethodsP‐HIFU power, duty cycle, and treatment duration were varied to generate different levels of thermal and mechanical deposition in rabbit muscle. Changes in T2‐weighted and T1 contrast‐enhanced (CE) signal were assessed immediately following treatment and at 24 h. Transport parameters were extracted by means of T1‐weighted dynamic contrast‐enhanced MRI (DCE‐MRI) technique at 0 and 24‐h time points.ResultsSuccessful p‐HIFU treatment was indicated by focal hyperintensity on the T2‐weighted image immediately post‐treatment, suggesting increased fluid (edema), with little intensity change in CE image. After 24 h, the affected region expanded along the muscle fiber accompanied by clear hyperintensity in CE image (contrast uptake). Quantitative DCE‐MRI analysis revealed statistically significant increases in both leakage rate and extracellular space, accompanied by a decrease in clearance rate.ConclusionSuccessful p‐HIFU treatment was mainly correlated to tissue heating. Tissue transport properties following treatment success would result in improved contact between drug and targets in both time and space. MRI is the key to controlling treatment by means of thermometry and also monitoring efficacy by means of T2‐weighted imaging. J. Magn. Reson. Imaging 2013;38:1094–1102. © 2013 Wiley Periodicals, Inc.
Blood oxygenation level dependent, blood volume, and blood flow responses to carbogen and hypoxic hypoxia in 9L rat gliomas as measured by MRI
Authors: Jerome Neil P. , Hekmatyar S. Khan , Kauppinen Risto A. 
Published: April 2013

PurposeTo study vascular responsiveness to hypoxia and hypercarbia together with vessel size index (VSI) in a 9L rat glioma (n = 11) using multimodal MRI.Materials and MethodsVSI was determined using T2 and MRI following AMI‐227 contrast agent. Blood oxygenation level dependent (BOLD) signal response was determined using T2 EPI MRI, blood volume changes using AMI‐227 and blood flow by means of continuous arterial spin labeling.ResultsVSI in the cortex, tumor rim, and core of 2.2 ± 1.0, 18.2 ± 5.4, and 23.9 ± 14.7 μm, respectively, showing a larger average vessel size in glioma than in the brain parenchyma. BOLD and blood volume signal changes to hypoxia and hypercapnia were much more profound in the tumor rim than the core. Hypoxia led to rim BOLD signal change that was larger in amplitude and it attained the low value much faster than either core or brain cortex. The vasculature in the rim appears more responsive to respiratory challenges in terms of volume adaptation than the core. Blood flow values within the gliomas were much lower than in the contralateral brain. Neither hypercarbia nor hypoxia had an effect on the tumor blood flow.ConclusionVascular responses of 9L gliomas to respiratory challenge, in particular hypoxia, are heterogeneous between the core and rim zones, potentially offering a means to classify and separate intratumor tissues with differing hemodynamic characteristics. J. Magn. Reson. Imaging 2014;39:110–119. © 2013 Wiley Periodicals, Inc.
Multicenter measurements of myelin water fraction and geometric mean T2: Intra‐ and intersite reproducibility
Authors: Meyers Sandra M. , Vavasour Irene M. , Mädler Burkhard , Harris Trudy , Fu Eric , Li David K.B. , Traboulsee Anthony L. , MacKay Alex L. , Laule Cornelia 
Published: April 2013

PurposeTo assess the reproducibility of myelin water fraction (MWF) and geometric mean T2 (GMT2), which are in vivo markers of pathological changes underlying disability and progression in diseases such as multiple sclerosis.Materials and MethodsFive healthy volunteers were scanned twice within 24 hours at six different sites using the same manufacturer's 3T magnetic resonance (MR) system. T2 distributions were produced by fitting multiecho 3D T2 data using non‐negative least squares, with stimulated echo correction. MWF, the fraction of signal with T2 between 15 and 40 msec to the entire signal, and GMT2, the mean T2 on a logarithmic scale from T2 between 40 and 200 msec, were examined in white matter.ResultsIntrasite coefficients of variation (COVs) were low (mean 3.99% for MWF and 0.51% for GMT2), as were intersite COVs (mean 4.68% for MWF, 0.31% for GMT2). Scan–rescan intraclass correlation coefficients (ICCs) (0.76 for MWF and 0.93 for GMT2) and Bland–Altman plots indicated good agreement between single site scans. Intersite ICCs were relatively high (0.69 for MWF and 0.92 for GMT2), revealing good intersite reliability.ConclusionMWF and GMT2 measures are reproducible between scans and across sites with an equivalent MR scanner and sequence protocol. Multicenter clinical trials using quantitative T2 relaxation are feasible. J. Magn. Reson. Imaging 2013;38:1445–1453. © 2013 Wiley Periodicals, Inc.
Within‐lesion differences in quantitative MRI parameters predict contrast enhancement in multiple sclerosis
Authors: Jurcoane Alina , Wagner Marlies , Schmidt Christoph , Mayer Christoph , Gracien Rene‐Maxime , Hirschmann Marc , Deichmann Ralf , Volz Steffen , Ziemann Ulf , Hattingen Elke 
Published: April 2013

PurposeTo investigate the relationship between quantitative magnetic resonance imaging (qMRI) and contrast enhancement in multiple sclerosis (MS) lesions. We compared maps of T1 relaxation time, proton density (PD), and magnetization transfer ratio (MTR) between lesions with and without contrast enhancement as quantified by the amount of T1 shortening postcontrast agent (CA).Materials and MethodsIn 17 patients with relapsing‐remitting MS (RRMS), 15 with progressive MS (PMS), and 17 healthy controls, T1, PD, and MTR were measured at 3T and T1‐mapping was repeated after CA administration. Manually drawn MS‐lesions (3D‐FLAIR) were labeled as enhancing if post‐CA T1‐shortening exceeded mean T1‐shortening in normal‐appearing white matter (NAWM) by at least 2 standard deviations. Precontrast T1, PD, and MTR were compared in enhancing lesions, nonenhancing lesions, NAWM, and gray matter.ResultsPrecontrast T1, PD, and MTR differed significantly between enhancing and nonenhancing lesions in RRMS and PMS patients (all P < 0.01). In PMS patients, PD of NAWM, enhancing, and nonenhancing lesions and MTR and T1 of gray matter differed significantly from RRMS and controls. Only MTR of gray matter differed between RRMS and controls.ConclusionContrast enhancement in MS quantified by relative T1 shortening may be predicted by precontrast abnormalities of T1, PD, and MTR and likely represents blood–brain barrier damage. J. Magn. Reson. Imaging 2013;38:1454–1461. © 2013 Wiley Periodicals, Inc.
In vivo identification of sentinel lymph nodes using MRI and size‐controlled and monodispersed magnetite nanoparticles
Authors: Iida Shuji , Imai Kensuke , Matsuda Sachiko , Itano Osamu , Hatakeyama Mamoru , Sakamoto Satoshi , Kokuryo Daisuke , Okabayashi Koji , Endo Takashi , Ishii Yoshiyuki , Hasegawa Hirotoshi , Aoki Ichio , Handa Hiroshi , Kitagawa Yuko 
Published: April 2013

PurposeTo develop a sentinel lymph node (SN) identification method using accurately synthesized magnetic nanoparticles (MNPs), as an enhanced specific SN tracer in combination with magnetic resonance imaging (MRI) in intact rodent and SN metastasis models.Materials and MethodsThree sizes of MNPs were originally synthesized. We developed an experimental rat SN model, with brachial lymph nodes (Br) as the SN and the axillary lymph node (Ax) as the second lymph node, and injection of MNPs via the front paw. SN detectability was evaluated in vivo using T1‐weighted MR images after injection of the synthesized MNPs, and the amount of iron in the Br and in the Ax was assessed using inductively coupled plasma optical emission spectrometry.ResultsThe highest ratios of the amount of iron in the Br versus the Ax were 3.1 and 3.3, using 20‐nm MNPs after 2‐ and 24‐hour injections. The appropriate dose and particle diameter for MRI detection was optimized, and the SN was optimally distinguished in the normal and metastatic rat models using MRI after a 0.4 mg/kg 20‐nm MNP injection.ConclusionWe developed and optimized a useful SN identification method using MRI in rodent models. J. Magn. Reson. Imaging 2013;38:1346–1355. © 2013 Wiley Periodicals, Inc.
Human myogenic endothelial cells exhibit chondrogenic and osteogenic potentials at the clonal level
Authors: Zheng Bo , Li Guangheng , Chen William C.W. , Deasy Bridget M. , Pollett Jonathan B. , Sun Bin , Drowley Lauren , Gharaibeh Burhan , Usas Arvydas , Péault Bruno , Huard Johnny 
Published: April 2013

AbstractWe have previously reported the high regenerative potential of murine muscle‐derived stem cells (mMDSCs) that are capable of differentiating into multiple mesodermal cell lineages, including myogenic, endothelial, chondrocytic, and osteoblastic cells. Recently, we described a putative human counterpart of mMDSCs, the myogenic endothelial cells (MECs), in adult human skeletal muscle, which efficiently repair/regenerate the injured and dystrophic skeletal muscle as well as the ischemic heart in animal disease models. Nevertheless it remained unclear whether human MECs, at the clonal level, preserve mMDSC‐like chondrogenic and osteogenic potentials and classic stem cell characteristics including high proliferation and resistance to stress. Herein, we demonstrated that MECs, sorted from fresh postnatal human skeletal muscle biopsies, can be grown clonally and exhibit robust resistance to oxidative stress with no tumorigeneity. MEC clones were capable of differentiating into chondrocytes and osteoblasts under inductive conditions in vitro and participated in cartilage and bone formation in vivo. Additionally, adipogenic and angiogenic potentials of clonal MECs (cMECs) were observed. Overall, our study showed that cMECs not only display typical properties of adult stem cells but also exhibit chondrogenic and osteogenic capacities in vitro and in vivo, suggesting their potential applications in articular cartilage and bone repair/regeneration. © 2013 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 31:1089–1095, 2013
Connection between the vibrational dynamics and the cross‐linking properties in cyclodextrins‐based polymers
Authors: Crupi Vincenza , Fontana Aldo , Giarola Marco , Majolino Domenico , Mariotto Gino , Mele Andrea , Melone Lucio , Punta Carlo , Rossi Barbara , Trotta Francesco , Venuti Valentina 
Published: April 2013

The vibrational dynamics of a new class of cross‐linked polymers obtained from both native and modified cyclodextrin, referred to as cyclodextrin nanosponges, is here investigated. The main purpose is to spot the structure of these materials at molecular level unlikely to be characterized by diffraction methods due to the low or null degree of crystallinity. The analysis of the spectral features of the vibrational bands observed between 1650 and 1800 cm−1 in both Raman and infrared spectra, and assigned to the carbonyl stretching modes of the polymeric network, is performed by using band deconvolution procedures. At the same time, a detailed inspection of the low‐wavenumber vibrational dynamics of these polymers is carried out, focusing on the modifications occurring on the so‐called boson peak.The simultaneous analysis of different wavenumber ranges in Raman and infrared spectra of cyclodextrin nanosponges allows us to develop a reliable strategy for exploring both the cross‐linking degree and the elastic properties of these innovative materials. The overall results give a complete characterization of the structural and dynamical properties of the system, in turn strictly connected to the entrapment/transport ability of these polymeric matrices. Copyright © 2013 John Wiley & Sons, Ltd.
The Increasing role of otolaryngology in the management of surgical thyroid disorders
Authors: Chambers Kyle J. , Bhattacharyya Neil 
Published: April 2013

Objectives/HypothesisTo determine trends in office visits and medical specialty seen for surgical diagnoses of the thyroid gland.Study DesignA cross‐sectional analysis of a national healthcare database.MethodsFrom the National Ambulatory Medical Care Survey (NAMCS), all cases of surgical thyroid disorders (e.g., benign neoplasm of thyroid gland, malignant neoplasm of thyroid gland, multinodular goiter) were extracted for 2 calendar year cohorts: 1995 to 1999 and 2005 to 2009. In addition to demographic information, the medical specialty of the health care provider seen was extracted. Comparisons were conducted for the proportion of surgical thyroid cases seen between general surgeons and otolaryngologists for the respective cohorts.ResultsIn the 1995 to 1999 cohort, there were a total of 107 ± 13 thousand outpatient visits annually to either general surgery or otolaryngology for surgical thyroid conditions. Among these, 62.7 ± 8.4 thousand visits (58.3 ± 5.6%) were seen by general surgery versus 44.8 ± 9.1 thousand (41.7 ± 5.6%) seen by otolaryngology. In comparison, in the 2005 to 2009 cohort, there were 218 ± 29 thousand visits annually for surgical thyroid conditions. Among these, 88.4 ± 17 thousand (40.5 ± 5.4%) were seen by general surgery versus 130 ± 21 thousand (59.5 ± 5.4%) seen by otolaryngology. The increase in proportion of surgical thyroid patients seen by otolaryngology in the second 5 year cohort was statistically significant (P = 0.032, chi‐square).ConclusionsThere is a national trend in the United States toward otolaryngologists seeing an increasing majority proportion of increasingly prevalent surgical thyroid conditions. These data objectively confirm the perceived increasing role of otolaryngologists in the management of surgical thyroid disorders on a national level.Level of Evidence2a. Laryngoscope, 123:3239–3242, 2013
Improvement in the detection of locoregional recurrence in head and neck malignancies: F‐18 fluorodeoxyglucose–positron emission tomography/computed tomography compared to high‐resolution contrast‐enhanced computed tomography and endoscopic examination
Authors: Rangaswamy Balasubramanya , Fardanesh M. Reza , Genden Eric M. , Park Eunice E. , Fatterpekar Girish , Patel Zara , Kim Jongho , Som Peter M. , Kostakoglu Lale 
Published: April 2013

Objectives/HypothesisTo compare the diagnostic efficacy of positron emission tomography (PET) with F‐18 fluorodeoxyglucose (FDG‐PET)/computed tomography (CT) to that of contrast‐enhanced high‐resolution CT (HRCT) and assess the value of a combinatorial approach in detection of recurrent squamous cell cancer of the head and neck (HNC) and to assess the efficacy of FDG‐PET/CT with and without HRCT in comparison to standard‐of‐care follow‐up—physical examination (PE) and endoscopy (E)—in determination of locally recurrent HNC.Study DesignRetrospective study.MethodsA total of 103 patients with HNC underwent FDG‐PET/CT and neck HRCT. There were two groups of patients: Group A had an FDG‐PET study acquired with low‐dose CT, and group B had an FDG‐PET study acquired with HRCT. The PET data obtained with or without HRCT were compared on a lesion and patient basis with the results of the PE/E.ResultsOn a lesion basis, both groups combined had higher sensitivity and negative predictive value (NPV) than the HRCT. Specificity and positive predictive value (PPV) for group B were higher than for group A. On a patient basis, both groups combined had a higher sensitivity and NPV than PE/E, respectively, although specificity of PE/E was higher than that of either group. PET data obtained with either protocol directly influenced treatment.ConclusionsHRCT increases the specificity and PPV of PET/CT when acquired simultaneously with PET. FDG‐PET/CT acquired with either LDCT or HRCT has higher accuracy than HRCT alone and increases the sensitivity and NPV of PE/E.Level of Evidence4 Laryngoscope, 123:2664–2669, 2013
Long‐term outcomes of surgery followed by radiation therapy for minor salivary gland carcinomas
Authors: Zeidan Youssef H. , Shultz David B. , Murphy James D. , An Yi , Chan Cato , Kaplan Michael J. , Colevas A. Dimitrios , Kong Christina , Chang Daniel T. , Le Quynh‐Thu 
Published: April 2013

Objectives/HypothesisPostoperative radiation therapy is often used in patients with high‐risk salivary gland carcinomas. In this study we evaluated the outcomes and prognostic factors in patients with minor salivary gland cancers treated with adjuvant radiation therapy.Study DesignRetrospective cohort study.MethodsWe performed a retrospective analysis of 90 patients treated with curative intent. Median follow‐up was 71 months. Fifty‐eight patients (64%) had adenoid cystic carcinomas, 22 (24%) had adenocarcinomas, and 10 (11%) had mucoepidermoid cancers. Primary disease site included 39 (43%) sinonasal, 35 (39%) oral cavity, 10 (11%) oropharynx, and six (7%) others. Twenty‐seven patients (30%) were treated with intensity‐modulated radiation therapy.ResultsEight local, four neck, and 24 distant relapses were detected. Local control rates at 5 and 10 years were 90% and 88%, respectively. Advanced T stage was associated with worse local control. Distant metastasis rates were 24% and 28% at 5 and 10 years, respectively. Tumor stage, histology, perineural invasion, and lymphovascular space invasion were significant predictors of distant metastasis on univariate analysis. However, on multivariate analysis only the American Joint Committee on Cancer stage was significant. Overall survival rates were 76% and 63% at 5 and 10 years, respectively. More advanced T stage and N stage correlated with worse overall survival.ConclusionsTumor stage remains the best predictor for locoregional and distant disease control of minor salivary gland cancers. Postoperative radiation therapy for high‐risk patients results in excellent long‐term locoregional disease control. Further work is needed to improve systemic control.Level of Evidence4. Laryngoscope, 123:2675–2680, 2013
Regenerative phonosurgical treatments for vocal fold scar and sulcus with basic fibroblast growth factor
Authors: Hirano Shigeru , Mizuta Masanobu , Kaneko Mami , Tateya Ichiro , Kanemaru Shin‐Ichi , Ito Juichi 
Published: April 2013

Objectives/HypothesisVocal fold scar and sulcus are still challenges. Basic fibroblast growth factor (bFGF) has proven to be effective to resolve scar tissue in animal models. This study reports the efficacy of regenerative treatments using bFGF on vocal fold scar and sulcus in human cases.Study DesignRetrospective chart review.MethodsFifteen cases (7 scar; 8 sulcus) were treated by either local injection of bFGF (n = 6) or regenerative surgery using bFGF (n = 9). Injection regimen was to locally apply 10 micrograms of bFGF in 0.5 mL saline into each vocal fold under topical anesthesia repeatedly (4 times with intervals of 1 week between each injection). The regenerative surgical procedure consisted of the dissection of scar tissue and the implant of gelatin sponge with bFGF. Follow‐up periods ranged from 6 months to 24 months.ResultsMaximum Phonation Time (MPT); Voice Handicap Index (VHI)−10; and Grade, Roughness, Breathiness, Asthenia, Strain (GRBAS) scale were assessed in both groups. The injection group showed significant improvement on VHI‐10 and GRBAS. The regenerative surgery group showed significant improvement in all parameters. Jitter and shimmer were evaluated in the surgery group, and the results indicated improvement in six and five cases of nine cases, respectively. No major adverse effects were observed in both treatment groups.ConclusionsRegenerative treatments using bFGF has shown to be effective for improvement of vocal function in scar and sulcus.Level of Evidence4. Laryngoscope, 123:2749–2755, 2013
Five adult laryngeal venous malformation cases treated effectively with sclerotherapy
Authors: Kamijo Atsushi , Hatsushika Kyousuke , Kanemaru Syuichiro , Moriyama Motohiro , Kase Yasuhiro , Masuyama Keisuke 
Published: April 2013

Objectives/HypothesisLaryngeal venous malformation is a comparatively rare condition in adults. It presents as a livid or bluish mass that may cause bleeding, hoarseness, stridor, and even difficulty in breathing. So far, treatment has largely consisted of laser therapy and surgical removal. Five cases of adult laryngeal venous malformations that were treated by sclerotherapy (local injection of monoethanolamine oleate solution) are reported. All lesions disappeared after one or two treatment sessions, and two of the five cases that presented recently were cured in the outpatient clinic setting with no sequelae. Sclerotherapy with monoethanolamine oleate is a safe, easy, and effective treatment for laryngeal venous malformations.Level of Evidence4. Laryngoscope, 123:2766–2769, 2013
Bilateral modified nasoseptal “rescue” flaps in the endoscopic endonasal transsphenoidal approach
Authors: Kim Boo Young , Shin Ji‐Hyeon , Kang Seok‐Gu , Kim Sung Won , Hong Yong Kil , Jeun Sin‐Soo , Kim Soo Whan , Cho Jin Hee , Park Yong Jin 
Published: April 2013

Objectives/HypothesisFor a wide exposure of skull base and preservation of septal mucosa, we have raised bilateral modified nasoseptal rescue flaps in the endoscopic endonasal transsphenoidal approach (EETSA) and evaluated the usefulness of these flaps elevation.Study DesignCase series.MethodsThe study population comprised the patients who underwent EETSA with bilateral modified nasoseptal rescue flaps elevation between February 2009 and June 2012. We retrospectively reviewed patients' medical records. Patients underwent preoperative nasal evaluation using the Nasal Obstruction Symptom Evaluation (NOSE), Sino‐Nasal Outcome Test (SNOT‐20), and a visual analogue scale (VAS) to assess several nasal symptoms. Repeat testing was performed 6 months postoperatively.ResultsA total of 92 patients underwent the EETSA with bilateral modified nasoseptal rescue flaps elevation. A total of 17 patients had intraoperative cerebrospinal fluid (CSF) leakage. Three patients underwent extension of the modified nasoseptal rescue flap to a conventional nasoseptal flap. No patients underwent reoperation due to CSF leakage. There was no statistical difference between preoperative and postoperative total SNOT‐20 and NOSE scores. According to the VAS, subjective olfaction function statistically worsened (P = 0.011) postoperatively.ConclusionBilateral modified nasoseptal rescue flaps elevation provided good exposure of the sellar floor, preserved the septal branch of sphenopalatine artery, and facilitated removal of sellar tumors. We could also preserve more septal mucosa by designing a novel incision and repositioning unused flaps to their original sites. Postoperative complications of the nasal cavity were thus minimized. We believe that this flap is very useful in a variety of settings during the EETSA.Level of Evidence4. Laryngoscope, 123:2605–2609, 2013
BAX/BCL2 RMFI ratio predicts better induction response in pediatric patients with acute myeloid leukemia
Authors: Sharawat Surender Kumar , Bakhshi Radhika , Vishnubhatla Sreenivas , Gupta Ritu , Bakhshi Sameer 
Published: April 2013

AbstractBAX/BCL2 ratio in pediatric AML has not been evaluated. In this first prospective study, we evaluated BAX/BCL2 transcript and RMFI ratio in 64 patients using real‐time PCR (TaqMan Probe chemistry) and flow‐cytometry, respectively. There was no correlation of BAX/BCL2 transcript ratio with RMFI ratio (R = −0.05; P = 0.715). Patients with WBC count >50,000/mm3 had lower BAX/BCL2 RMFI ratio (P = 0.043), whereas no difference in ratio was observed among patients of different cytogenetics subgroups (P = 0.786). Higher BAX/BCL2 RMFI ratio was associated positively with CR rate (P = 0.03), but this study was unable to show that it translated into improved EFS or OS. Pediatr Blood Cancer 2013;60E63‐E66. © 2013 Wiley Periodicals, Inc.