bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Pd‐Catalyzed Carbonylative α‐Arylation of Aryl Bromides: Scope and Mechanistic Studies.
Authors: Nielsen Dennis U. , Lescot Camille , Goegsig Thomas M. , Lindhardt Anders T. , Skrydstrup Troels 
Published: May 2014

AbstractThe reactions are carried out in a bridged two‐chamber system (COware) which releases stoichiometric amounts of CO‐gas, generated from COgen (I) in chamber B, into the reaction chamber A.
ChemInform Abstract: A Novel Green Synthesis of α/β‐Amino Acid Functionalized Pyrimidinone Peptidomimetics Using Triazole Ligation Through Click‐Multi‐Component Reactions.
Authors: Balan Biny , Bahulayan D. 
Published: May 2014

AbstractDihydropyrimidinone precursors undergo 1,3‐dipolar cycloaddition with small peptide like azides, generated from Ugi or alternate Mannich type multicomponent reactions.
ChemInform Abstract: Generation and Conjugate Additions of O‐Quinone Methides under Mild Base Conditions: Rapid Synthesis of N‐Substituted Aryl Glycine Derivatives.
Authors: Wang Wei , Zheng Zhong , Wang Xiangmin , Chen Jinchun 
Published: May 2014

AbstractA mild and one‐step protocol for the synthesis of the title compounds from (ortho‐hydroxymethyl)aryl benzoates is reported.
ChemInform Abstract: Ruthenium(II) Complexes of Hybrid 8‐Hydroxyquinoline‐thiosemicarbazone Ligands: Synthesis, Characterization and Catalytic Applications.
Authors: Nirmala M. , Manikandan R. , Prakash G. , Viswanathamurthi P. 
Published: May 2014

AbstractA total of nine different hydroxyquinoline‐thiosemicarbazone complexes are prepared revealing similar catalytic activities.
ChemInform Abstract: 1,3‐Carbothiolation of 4‐(Trifluoromethyl)‐p‐quinols: A New Access to Functionalized (Trifluoromethyl)arenes.
Authors: Liu Xiao , Pan Ling , Dong Jinhuan , Xu Xianxiu , Zhang Qian , Liu Qun 
Published: May 2014

AbstractTreatment of the title substrate (I) with various ketene dithioacetals results in the formation of α‐arylated β‐ketothiolesters, nitriles, and carbonyl compounds via a tandem 1,3‐carbothiolation/aromatization sequence.
ChemInform Abstract: Asymmetric Catalytic Sulfoxidation with H2O2 Using Chiral Copper Metal—Organic Framework Crystals.
Authors: Tanaka Koichi , Kubo Kaori , Iida Kazuhiro , Otani Ken‐ichi , Murase Takanori , Yanamoto Daisuke , Shiro Motoo 
Published: May 2014

AbstractGenerally hydrogen peroxide is more effective than the urea/hydrogen peroxide complex.
ChemInform Abstract: KF/Clinoptilolite, An Effective Solid Base in Ullmann Ether Synthesis Catalyzed by CuO Nanoparticles.
Authors: Khalilzadeh Mohammad A. , Keipour Hoda , Hosseini Abolfazl , Zareyee Daryoush 
Published: May 2014

AbstractThe products are obtained in much lower yields when aryl bromides are used.
ChemInform Abstract: Building Block Synthesis of Predominantly (E) Symmetrical and Unsymmetrical 1,2‐Difluorostilbenes from 1,2‐Dibromo‐1,2‐difluoroethene.
Authors: Eddarir Said , Kajjout Mohammed , Rolando Christian 
Published: May 2014

AbstractA general route for the synthesis of the title compounds via the Suzuki‐Miyaura cross coupling reaction is developed.
ChemInform Abstract: 1‐Azadienes as Regio‐ and Chemoselective Dienophiles in Aminocatalytic Asymmetric Diels—Alder Reaction.
Authors: Ma Chao , Gu Jing , Teng Bin , Zhou Qing‐Qing , Li Rui , Chen Ying‐Chun 
Published: May 2014

AbstractAzadienes (I) and (VI) act as regio‐ and chemoselective dienophiles in the amine catalyzed asymmetric Diels—Alder reactions with dienal (II).
ChemInform Abstract: A Defunctionalization Concept for the Convenient Synthesis of Bis(5‐arylfuran‐2‐yl)methane Scaffolds.
Authors: Tiwari Praveen Kumar , Mukhopadhyay Tufan , Aidhen Indrapal Singh 
Published: May 2014

AbstractAn interesting formation of bis(5‐arylfuran‐2‐yl)methanes is described involving TFA‐mediated dimerization of enantiopure tartaric acid derived ketones (III) and (V).
ChemInform Abstract: Palladium(II)‐Catalyzed Cyclizative Cross‐Coupling of ortho‐Alkynylanilines with ortho‐Alkynylbenzamides under Aerobic Conditions
Authors: Yao Bo , Wang Qian , Zhu Jieping 
Published: May 2014

Abstractleading to the formation of two different heterocycles tethered by a tetrasubstituted double bond
ChemInform Abstract: NBS‐Mediated Sequential One‐Pot Synthesis of Multifunctionalized Thiazoles and Thiophenes from 1,3‐Dicarbonyl Compounds and Mercaptonitrile Salts.
Authors: Luo Laichun , Meng Lanlan , Sun Qi , Ge Zemei , Li Runtao 
Published: May 2014

AbstractThe advantages of the title method include mild reaction conditions, simple operation, broad substrate scope, and short reaction times.
ChemInform Abstract: HClO4‐SiO2 as an Efficient and Reusable Heterogeneous Catalyst for the Synthesis of 1‐Substituted Tetrazoles.
Authors: Bahari Siavash , Rezaei Akbar 
Published: May 2014

AbstractA green and solvent‐free synthesis of 1‐substituted tetrazoles from primary amines, triethyl orthoformate and sodium azide is described.
ChemInform Abstract: Niobium Pentachloride Catalyzed One‐Pot Multicomponent Condensation Reaction of β‐Naphthol, Aryl Aldehydes and Cyclic 1,3‐Dicarbonyl Compounds
Authors: Nasseri Mohammad A. , Allahresani Ali , Esmaeili Abbas A. 
Published: May 2014

Abstractas a new, mild and efficient method for the synthesis of xanthene derivatives (29 examples)
ChemInform Abstract: Addition of Organometallic Reagents to Chiral N‐Methoxylactams: Enantioselective Syntheses of Pyrrolidines and Piperidines.
Authors: Jaekel Mascha , Qu Jianping , Schnitzer Tobias , Helmchen Guenter 
Published: May 2014

AbstractApplication of this method is demonstrated in the total syntheses of two natural alkaloids, i.e.
ChemInform Abstract: Copper‐Catalyzed N‐ and O‐Arylation of Amides: Alternative Approaches to 3,4‐Dihydroquinolin‐2‐ones, Quinolin‐2‐ones, and 12H‐Chromeno[2,3‐b]quinolin‐12‐ones.
Authors: Zhang Xinying , Guo Xiaojie , Fang Liangliang , Song Yunping , Fan Xuesen 
Published: May 2014

AbstractCopper‐catalyzed reaction of o‐bromobenzyl bromides with cyanoacetamide results in formation of 3‐cyano‐3,4‐dihydroquinolines of type (III).
ChemInform Abstract: Copper(I)‐Catalyzed Intermolecular Cyclization of Methyl Perfluoroalk‐2‐ynoates with o‐Aminophenyl Ketones: Access to 2‐Perfluoroalkylated Quinolines.
Authors: Han Jing , Li Li , Shen Yangyong , Chen Jie , Deng Hongmei , Shao Min , Lu Xuesheng , Zhang Hui , Cao Weiguo 
Published: May 2014

AbstractThis novel, one‐pot, two‐step process gives access to a wide range of different functionalized quinoline derivatives under mild reaction conditions.
ChemInform Abstract: A New Route to α‐Carbolines Based on 6π‐Electrocyclization of Indole‐3‐alkenyl Oximes.
Authors: Markey Sophie J. , Lewis William , Moody Christopher J. 
Published: May 2014

AbstractOlefination of 3‐indolyl aldehydes or ketones provide indole‐3‐alkenyl oximes, which upon microwave heating undergo Boc‐deprotection, 6π‐electrocyclization, and aromatization to form α‐carbolines.
ChemInform Abstract: N,N‐Bond Formation in Intramolecular Cobalt‐Catalyzed [2 + 2 + 2] Cyclizations of Alkynyl‐Linked Bisnitriles, and the Preparation of Annulated Pyridazines.
Authors: Snyder John K. , Cai Cuifang , Audet Megan A. 
Published: May 2014

AbstractSubstitution at the propargyl position increases the steric hindrance and inhibits the reaction.
ChemInform Abstract: Catalytic Application of Task Specific Ionic Liquid on the Synthesis of Benzoquinazolinone Derivatives by a Multicomponent Reaction.
Authors: Rahman Matiur , Sarkar Anirban , Ghosh Monoranjan , Majee Adinath , Hajra Alakananda 
Published: May 2014

AbstractSulfobutyl substituted ionic liquid (IMS) efficiently catalyzes the Biginelli reaction of α‐tetralone, aldehyde, and urea or thiourea to afford benzoquinazoline derivatives.
ChemInform Abstract: Boric Acid in Aqueous Micellar Medium: An Effective and Recyclable Catalytic System for the Synthesis of Aryl‐7,8‐dihydro[1,2,4]triazolo[4,3‐a]pyrimidine‐6‐carbonitriles.
Authors: Singh Mandavi , Fatma Shahin , Ankit Preyas , Singh Shyam Babu , Singh Jagdamba 
Published: May 2014

AbstractBiginelly type reaction of aminotriazole, aromatic aldehyde, and malononitrile under aqueous micellar conditions provides the title compounds in high yields and short reaction times.
ChemInform Abstract: Synthesis, Characterization, and Physical Properties of Two Novel Nonaheteroacene Derivatives.
Authors: Li Gang , Gao Junkuo , Hu Fangzhong , Zhang Qichun 
Published: May 2014

AbstractThe title compounds (III) and (V) are synthesized through cyclocondensation of the dione (I) with appropriate o‐phenylenediamines (II) and (IV) (both applied as hydrochlorides).
ChemInform Abstract: Synthesis of Polyhydroxylated Carbo‐Bicyclic Compounds from Sugar Allyltins.
Authors: Magdycz Marta , Jarosz Slawomir 
Published: May 2014

AbstractThe functionalized dienoaldehyde (I), generated as previously reported from a D‐glucose allyltin derivative, can be easily converted to the corresponding carbo‐bicyclic polyols, such as compound (VI).
ChemInform Abstract: Formation of C‐Glycosides by Ferrier Reaction.
Authors: Wieczorek Eusebius , Thiem Joachim 
Published: May 2014

AbstractPeracylated glycals, such as (I), are treated with terminal alkynes, e.g. (II), under Lewis acid catalysis to give anomerically pure (E)‐configurated 2‐halo‐hex‐2‐enopyranosides exclusively.
ChemInform Abstract: Studies on Difficult Intramolecular Hydroaminations in the Context of Four Syntheses of Alkaloid Natural Products.
Authors: Dion Isabelle , Vincent‐Rocan Jean‐Francois , Zhang Lei , Cebrowski Pamela H. , Lebrun Marie‐Eve , Pfeiffer Jennifer Y. , Bedard Anne‐Catherine , Beauchemin Andre M. 
Published: May 2014

AbstractIt is found that under appropriate conditions commonly difficult intramolecular hydroamination of several internal alkenes yielding 6‐membered N‐heterocyclic ring systems can be performed successfully.
ChemInform Abstract: Total Syntheses of Bacillamide C and Neobacillamide A; Revision of Their Absolute Configurations.
Authors: Martinez Veronica , Davyt Danilo 
Published: May 2014

AbstractThe stereospecific syntheses of compounds (I) from (L)‐(+)‐alanine show that their spectroscopic data and optical activities are consistent with those reported for bacillamide C and neobacillamide A.
ChemInform Abstract: A Concise Total Synthesis of Arizonins B1 and C1.
Authors: Fernandes Rodney A. , Mulay Sandip V. , Chavan Vijay P. 
Published: May 2014

AbstractThe title compounds are obtained via a key building block alkyne which is prepared from D‐glucono‐δ‐lactone and employed in the Doetz benzannulation to construct the naphthalene unit.
ChemInform Abstract: Total Synthesis of (‐)‐Seimatopolide A.
Authors: Kavitha Nerella , Kumar Vemula Praveen , Reddy Cirandur Suresh , Chandrasekhar Srivari 
Published: May 2014

AbstractTitle compound (I) is synthesized in a linear fashion with high yielding steps and utilizing Sharpless asymmetric dihydroxylation, Pd‐catalyzed allylic reduction, and Kitas macrolactonization as the key steps.
ChemInform Abstract: Peniciketals A—C, New Spiroketals from Saline Soil Derived Penicillium raistrichii.
Authors: Liu Wei‐Zhong , Ma Li‐Ying , Liu De‐Sheng , Huang Yu‐Ling , Wang Chun‐Hua , Shi Shou‐Sen , Pan Xiao‐Hong , Song Xiao‐Dong , Zhu Rong‐Xiu 
Published: May 2014

AbstractThe title compounds show selective cytotoxic effects on HL‐60 cell lines.
ChemInform Abstract: One‐Pot Synthesis of (‐)‐Oseltamivir and Mechanistic Insights into the Organocatalyzed Michael Reaction.
Authors: Mukaiyama Takasuke , Ishikawa Hayato , Koshino Hiroyuki , Hayashi Yujiro 
Published: May 2014

AbstractThe synthesis of title compound (I) is achieved via the asymmetric Michael reaction of pentanyloxyacetaldehyde with nitroethenylacetamide as the key step in seven steps and 36% overall yield.
ChemInform Abstract: Purification of NaYF4‐Based Upconversion Phosphors.
Authors: Stepuk Alexander , Casola Gioele , Schumacher Christoph M. , Kraemer Karl W. , Stark Wendelin J. 
Published: May 2014

AbstractA novel technique for transforming cubic α‐NaYF4 phosphors into the hexagonal modification is presented for the removal of O impurities that hinder upconversion luminescence.
ChemInform Abstract: New Theoretical Investigation on the Electronic Structure and Magnetic Interaction for Both Cubic SrFeO3 and CaFeO3 Oxides: Comparison Between GGA and GGA + U Approaches
Authors: Hamdad N. , Rozale H. , Lakdja A. , Chahed A. , Benhelal O. 
Published: May 2014

AbstractReview: 68 refs.
ChemInform Abstract: Valorization of Industrial Waste and By‐Product Streams via Fermentation for the Production of Chemicals and Biopolymers
Authors: Koutinas Apostolis A. , Vlysidis Anestis , Pleissner Daniel , Kopsahelis Nikolaos , Lopez Garcia Isabel , Kookos Ioannis K. , Papanikolaou Seraphim , Kwan Tsz Him , Lin Carol Sze Ki 
Published: May 2014

AbstractReview: 305 refs.
Nitrogen Uptake and Use Efficiency of Invasive Spartina alterniflora and Native Phragmites australis: Effect of Nitrogen Supply
Authors: Qing Hua , Cai Ying , Xiao Yan , Yao Yihan , An Shuqing 
Published: May 2014

AbstractPlant roots play a vital role in acquisition of resources, while their potential role in plant successful invasions has been largely overlooked. Spartina alterniflora is an invasive grass that has expanded dramatically on the Chinese coast, outcompeting native plant Phragmites australis and resulting in serious negative consequences for invaded ecosystems. In this study, we evaluated differences between S. alterniflora and P. australis in nitrogen uptake and use efficiency as well as plasticity of nitrogen characteristics and additional morphological traits in response to increased nitrogen supply. We grew two species in monoculture and mixed‐culture pots under two nitrogen levels in a greenhouse environment. After growing for 17 weeks, plants were exposed to 15N‐labeled ammonium chloride for 48 h and harvested to compare the uptake of nitrogen. Invasive S. alterniflora showed significantly higher biomass, root mass ratio, and nitrogen use efficiency but lower 15N uptake rate than native P. australis in both monocultures and mixed‐cultures, regardless of nitrogen levels. Nitrogen supply significantly increased biomass, total 15N uptake, and 15N uptake rate but decreased root mass ratio and nitrogen use efficiency of both species regardless of culture form, with biomass and total 15N uptake of S. alterniflora responding more strongly to nitrogen supply than the corresponding traits of P. australis when the two species were grown in a mixed culture. Our results suggested that the greater root mass ratio and nitrogen use efficiency of S. alterniflora played a greater role than root nitrogen capture capacity in its successful invasion.
Improvement of Oxygen Release from Calcium Peroxide‐polyvinyl Alcohol Beads by Adding Low‐cost Bamboo Biochar and Its Application in Bioremediation
Authors: Wu Chih‐Hung , Chang Shih‐Hsien , Lin Chi‐Wen 
Published: May 2014

AbstractA limited concentration of dissolved oxygen commonly reduces the effectiveness of groundwater bioremediation. A novel bamboo biochar oxygen‐releasing bead (ORB) was prepared and its application in groundwater bioremediation was evaluated. The results reveal that bamboo biochar effectively adsorbed benzene, toluene, ethylene, and xylene. The Freundlich model described the adsorption behavior (R2 = 0.990) well. The response surface method was used to prepare biochar‐ORBs. Results indicate that the proportions of calcium peroxide, citrate, polyvinyl alcohol, and bamboo biochar for the optimal oxygen‐releasing capacity of biochar‐ORBs were 20:2.22:9.23:31.5 (w/w/w/w). A multiple linear regression equation effectively predicted oxygen releasing capacity (R2 = 0.991). A column experiment indicated that the period of oxygen release from biochar‐ORBs (104 days) was much longer than that from ORBs (51 days). The mechanical strength of biochar‐ORBs (disintegration ratio: 3.4%) exceeded that of ORBs (disintegration ratio: 6.9%). Degraders that contained biochar‐ORBs rapidly removed 99% toluene at a concentration of 45.6 mg L−1. Scanning electron microscopy showed that degraders attached to and grew on biochar‐ORBs following bioremediation. Taken together, the results reveal that biochar‐ORB is a potential oxygen‐releasing material for use in groundwater bioremediation.
Effect of osteopontin in regulating bone marrow mesenchymal stem cell treatment of skin wounds in diabetic mice
Authors: Meng Hao , Wang Zhenxiang , Wang Wenping , Li Wei , Wu Qinan , Lei Xiaotian , Ouyang Xinshou , Liang Ziwen 
Published: May 2014

AbstractBackgroundWe aimed to investigate the role of osteopontin in regulating mesenchymal stem cells transplanted to promote wound healing in diabetic mice.MethodsThe mesenchymal stem cells of osteopontin knock‐out (KO) and wild‐type (WT) mice were isolated separately for in vitro culture and characterization. A skin wound on the back of mice was established by skin punching. In 27 osteopontin KO male mice, induced diabetes mellitus was via intraperitoneal injection of streptozotocin. 9 normal mice were used as controls. The mice were divided into four groups and injected with Dulbecco's modified Eagle's medium (DMEM) or mesenchymal stem cells via the tail vein: A (diabetic mice injected with DMEM), B (diabetic mice injected with osteopontin KO mesenchymal stem cells), C (diabetic mice injected with WT mesenchymal stem cells), D (normal mice injected with DMEM). The healing times and closure rates of skin wounds were recorded. The microvessel density of healing wounds was measured, and the localized expression of osteopontin was identified by western blotting and immunohistochemistry. The migration of mesenchymal stem cells was observed on normal mice with skin wound injected with mesenchymal stem cells of C57BL6~GFP transgenic mice, which show green fluorescent under UV light.ResultsCompared with normal mice, the healing time of wounds in the mice with diabetes and osteopontin KO was significantly prolonged (p < 0.01). After transplanting osteopontin KO mesenchymal stem cells, the healing time was slightly shorter. Meanwhile, the healing time was significantly shorter after transplanted with WT mesenchymal stem cells and more significant neovascularization at healing wounds (p < 0.05). The expression of osteopontin in local healing wounds after transplantation of WT mesenchymal stem cells was demonstrated with western blotting and immunohistochemistry. After 4 days, the green fluoresces were noted on the wounds of mice injected with mesenchymal stem cells of fluorescent mice.ConclusionsMesenchymal stem cells can migrate to wound sites, and osteopontin plays a regulatory role in mesenchymal stem cells promoting the healing of diabetic skin wounds. Copyright © 2014 John Wiley & Sons, Ltd.
Synthesis and Biological Activity of Triazole‐Appended N,O‐Nucleosides
Authors: Romeo Roberto , Giofrè Salvatore V. , Carnovale Caterina , Chiacchio Maria A. , Campisi Agata , Mancuso Raffaella , Cirmi Santa , Navarra Michele 
Published: May 2014

Abstract1,2,3‐Triazole‐appended N,O‐nucleosides have been synthesized by an approach combining a 1,3‐dipolar cycloaddition process and an alkyne–azide click chemistry reaction. Biological assays, performed on six tumor cell lines, revealed the antiproliferative activity of the synthesized compounds. The effect was more evident in the U87MG human glioblastoma cell line. Thus, these nucleoside analogues could be promising scaffolds for the construction of new anticancer agents.
The log‐power‐normal distribution is the exponentiated lognormal distribution
Authors: Nadarajah S. , Afuecheta E. , Chan S. 
Published: May 2014

AbstractWe point out that the log‐power‐normal distribution introduced in Martínez‐Flórez, Bolfarine and Gómez [Environmetrics, 25, 2014, 44‐56] is the exponentiated lognormal distribution known since 2006. Copyright © 2014 John Wiley & Sons, Ltd.
Spatiotemporal modeling of odds of disease
Authors: Torabi Mahmoud 
Published: May 2014

AbstractThe analysis of geographical and temporal variability of binomial data, using generalized additive mixed models, are considered. In this class of models, spatially correlated random effects and temporal components are adopted. The frequentist analysis of these complex models is computationally difficult. Recently developed method of data cloning has overcome the computational challenges of the analysis of mixed models from the frequentist approach. We use data cloning, which yields to maximum likelihood estimation, to propose frequentist analysis of spatiotemporal modeling of odds of disease. The advantages of the data cloning approach are that the prediction and prediction interval of the smoothing odds over space and time are easily obtained. We illustrate this approach using a real dataset of yearly asthma physician visits by children in the province of Manitoba, Canada, during 2000–2010. The performance of the proposed approach is also studied through a simulation study. Copyright © 2014 John Wiley & Sons, Ltd.
A bridge to nowhere: methane emissions and the greenhouse gas footprint of natural gas
Authors: Howarth Robert W. 
Published: May 2014

AbstractIn April 2011, we published the first peer‐reviewed analysis of the greenhouse gas footprint (GHG) of shale gas, concluding that the climate impact of shale gas may be worse than that of other fossil fuels such as coal and oil because of methane emissions. We noted the poor quality of publicly available data to support our analysis and called for further research. Our paper spurred a large increase in research and analysis, including several new studies that have better measured methane emissions from natural gas systems. Here, I review this new research in the context of our 2011 paper and the fifth assessment from the Intergovernmental Panel on Climate Change released in 2013. The best data available now indicate that our estimates of methane emission from both shale gas and conventional natural gas were relatively robust. Using these new, best available data and a 20‐year time period for comparing the warming potential of methane to carbon dioxide, the conclusion stands that both shale gas and conventional natural gas have a larger GHG than do coal or oil, for any possible use of natural gas and particularly for the primary uses of residential and commercial heating. The 20‐year time period is appropriate because of the urgent need to reduce methane emissions over the coming 15–35 years.
Time‐dependent finite element simulations of a shear‐thinning viscoelastic fluid with application to blood flow
Authors: Donev I. G. , Reddy B. D. 
Published: May 2014

SUMMARYA new finite element method is developed to simulate time‐dependent viscoelastic shear‐thinning flows characterized by the generalized Oldroyd‐B model. The focus of the algorithm is improved stability through a free‐energy dissipative scheme by using low‐order piecewise‐constant finite element approximations for stress. The algorithm is further modified by incorporating a pressure‐projection method, a DG‐upwinding scheme, a symmetric interior penalty DG method to solve the elliptic pressure‐update equation and a geometric multigrid preconditioner. The improved stability and cost to accuracy is compared when using higher order discontinuous bilinear approximation, where in addition, we consider the influence of a slope limiter for these elements. The algorithm is applied to the 2D start‐up‐driven cavity problem, and the stability of the free energy is illustrated and compared between element choices. An application of the model to modelling blood in small arterioles and channels is considered by simulating pulsatile blood flow through a stenotic arteriole. The individual influences of viscoelasticity and shear‐thinning within the generalized Oldroyd‐B model are investigated by comparing results to the Newtonian, generalized Newtonian and Oldroyd‐B models. Copyright © 2014 John Wiley & Sons, Ltd.