bluuebunny/crossref_metadata_2025_split huggingface dataset:
Removal of Ni(II) from aqueous solution using chemically modified cellulose nanofibers derived from orange peels
Authors: Matsedisho B. , Otieno B. , Kabuba J. , Leswifi T. , Ochieng A. 
Published: June 2024

Abstract
Orange peel waste is generally of low economic value even though it contains components such as cellulose which can be utilised to produce nanocellulose adsorbents for wastewater remediation. This study was aimed at improving the chemical and physical properties of cellulose nanofibers derived from modified orange peel (OP) biosorbent. The OP was chemically modified using Phosphoric acid (POP) and Sodium hydroxide (NaOP) and applied for the removal of Ni(II) contained in wastewater. Biosorbent characterisation using Fourier transform infrared spectrometer revealed the presence of acidic carboxyl groups, the principal ligands responsible for metal binding. Increased crystallinity due to chemical treatment was confirmed by X-ray diffraction, while Transmission Electron microscopy and Scanning electron microscopy analyses confirmed the formation of nanofibers. The raw and modified orange peel fibres had surface areas of 0.948 m2/g and 1.428 m2/g, respectively, obtained from the Brunauer–Emmett–Teller analyser. From the batch adsorption studies, the optimum pH values were between 5 and 6, equilibrium was reached within one hour and thirty minutes for all the biosorbents, and the optimum adsorbent mass was 4 g/L. The Langmuir equation provided the best fit with maximum uptake capacities of 37.5, 21.08 and 8.4 mg/g for POP, NaOP, and OP, respectively. Compared to the raw orange peel, the adsorption capacities of the chemically modified orange peels were higher, with POP having the highest adsorption capacity of 37.5 mg/g.
Weight change patterns across adulthood are associated with the risk of osteoarthritis: a population-based study
Authors: Cui Aiyong , Zhang Jun , Deng Hongli , Wei Xing , Zhuang Yan , Wang Hu 
Published: June 2024

Abstract
Background
Body weight has been recognized as a driving factor of osteoarthritis. Few studies had investigated the association between weight status across adulthood and risk of osteoarthritis (OA). This study investigates the association of weight change patterns across adulthood (lasting at least 25 years) with the risk of OA from the National Health and Nutrition Examination Survey (NHANES) 2013–2018.

Methods
The study assessed the relationship between weight change across adulthood and OA in 7392 individuals aged > 50 spanning a minimum of 25 years. Multivariate linear regression analyses were utilized to detect the association between weight change patterns and self-reported OA. Restricted cubic splines (RCS) were used to examine the nonlinear relationship between absolute weight change and OA risk.

Results
From 10 years ago to survey, the risk of OA was 1.34-fold (95% CI 1.07–1.68) in people changed from obese to non-obese, 1.61-fold (95% CI 1.29–2.00) in people change from non-obese to obese, and 1.82-fold (95% CI 1.49–2.22) in stable obese people compared with people who were at stable normal weight. Similar patterns were also observed at age 25 years to baseline and age 25 years to 10 years before the baseline. The dose–response association of RCS found a U-shaped relationship between absolute weight change and OA risk.

Conclusions
The study suggests that weight patterns across adulthood are associated with the risk of OA. These findings stressed important to maintain a normal weight throughout adulthood, especially to prevent ignored weight gain in early adulthood to reduce OA risk later.
Recommending suitable hotels to travelers in the post-COVID-19 pandemic using a novel FAHP-fuzzy TOPSIS approach
Authors: Chen Tin-Chih Toly , Wu Hsin-Chieh , Hsu Keng-Wei 
Published: June 2024

AbstractCities around the world have reopened from the lockdown caused by the COVID-19 pandemic, and more and more people are planning regional travel. Therefore, it is a practical problem to recommend suitable hotels to travelers amid the COVID-19 pandemic. However, it is also a challenging task since the criteria that affect hotel selection amid the COVID-19 pandemic may be different from those usually considered. From this perspective, a novel fuzzy analytic hierarchy process (FAHP)-fuzzy technique for order preference by similarity to ideal solution (fuzzy TOPSIS) approach is proposed in this study for hotel recommendation. The proposed methodology not only considers the criteria affecting hotel selection amid the COVID-19 pandemic, but also establishes a systematic mechanism to simultaneously improve the accuracy and efficiency of the recommendation process. The novel FAHP-fuzzy TOPSIS approach has been successfully applied to recommend suitable hotels to fifteen travelers for regional trips amid the COVID-19 pandemic.
Advancements in fiber-reinforced polymer (FRP) composites: an extensive review
Authors: mahboubizadeh Shahram , Sadeq Abdellatif , Arzaqi Zahra , Ashkani Omid , Samadoghli Mobin 
Published: June 2024

AbstractRecent advancements in material sciences have underscored the increasing utilization of composite materials, notably polymer-based composites, renowned for their exceptional tensile strength and lightweight characteristics. The tailored fiber structures within these composites, and their strategic placement within the polymer matrix, are pivotal in modifying the resultant composite's properties. This review article systematically examines the diverse attributes of Fiber-Reinforced Polymer (FRP) composites, including their manufacturing techniques, mechanical properties, and application domains. In this article, the role of natural and artificial fibers in the development of FRP composites is discussed. It has also been observed that new research is being done in the direction of quantum dots (QDs) in order to improve some features of FRP composites. A particular focus is placed on how different fiber weaves and orientations impact the overall performance and utility of FRP components. By aggregating and analyzing current research, this paper aims to elucidate the complexities of FRP composites and forecast trends in their development and use. Also, in the final part, a review of the importance of additive manufacturing in the development of FRP composites has been done.
Neoadjuvant programmed cell death 1 blockade combined with chemotherapy for locally advanced head and neck squamous cell carcinoma
Authors: Han Ping , Liang Faya , Song Pan , Wu Taowei , Li Yangyang , Gao Ming , Lin Peiliang , Fan Jianming , Huang Xiaoming 
Published: June 2024

Abstract
Purpose
Anatomical structures and organ preservation concepts of the head and neck are important for patients with locally advanced head and neck squamous cell carcinoma (LA HNSCC). Neoadjuvant chemotherapy has been applied to improve organ preservation; however, pathological complete remission is still unsatisfactory. The purpose of this study was to explore the pathological complete response (pCR) rate and safety of immune checkpoint blockade combined with neoadjuvant chemotherapy (NAC) in patients with LA HNSCC.

Methods
Fifty-one patients participated in this retrospective study, and of these, 25 received NAC only (cisplatin+5-fluorouracil+nab-paclitaxel), and 26 received NAC (cisplatin+5-fluorouracil) plus pembrolizumab. Pathological complete remission, the objective response rate (ORR), delayed surgery and toxicity were compared between the two groups.

Results
A significant difference was observed in the pCR rate and ORR between the NAC+ICB group and the NAC group. Delaying surgery and Grade 3 or 4 AEs occurred more frequently in the NAC group. In the NAC-only group, during a median follow-up period of 31.80 months, the recurrence-free survival (RFS) rate was 80.0%, the disease-free survival (DFS) rate was 80.0% and the overall survival (OS) rate was 88.0%. In the NAC+ICB group, during the median follow-up period of 22.99 months, the RFS rate was 96.2%, the DFS rate was 96.2% and the OS rate was 100%.

Conclusion
The combination of pembrolizumab with NAC could improve the pathological response without increasing the risk of toxicity, which provides pathological evidence for the treatment of LA HNSCC patients with NAC+ICB.
X-Model4Rec: An Extensible Recommender Model Based on the User’s Dynamic Taste Profile
Authors: de Azambuja Rogério Xavier , Morais A. Jorge , Filipe Vítor 
Published: June 2024

AbstractSeveral approaches have been proposed to obtain successful models to solve complex next-item recommendation problem in non-prohibitive computational time, such as by using heuristics, designing architectures, and applying information filtering techniques. In the current technological scenario of artificial intelligence, sequential recommender systems have been gaining attention and they are a highly demanding research area, especially using deep learning in their development. Our research focuses on an efficient and practical model for managing sequential session-based recommendations of specific products for users using the wine and movie domains as case studies. Through an innovative recommender model called X-Model4Rec – eXtensible Model for Recommendation, we explore the user's dynamic taste profile using architectures with transformer and multi-head attention mechanisms to solve the next-item recommendation problem. The performance of the proposed model is compared to that of classical and baseline recommender models on two real-world datasets of wines and movies, and the results are better for most of the evaluation metrics.
PrimitiveNet: decomposing the global constraints for referring segmentation
Authors: Liu Chang , Jiang Xudong , Ding Henghui 
Published: June 2024

AbstractIn referring segmentation, modeling the complicated constraints in the multimodal information is one of the most challenging problems. As the information in a given language expression and image becomes increasingly abundant, most of the current one-stage methods that directly output the segmentation mask encounter difficulties in understanding the complicated relationships between the image and the expression. In this work, we propose a PrimitiveNet to decompose the difficult global constraints into a set of simple primitives. Each primitive produces a primitive mask that represents only simple semantic meanings, e.g., all instances from the same category. Then, the output segmentation mask is computed by selectively combining these primitives according to the language expression. Furthermore, we propose a cross-primitive attention (CPA) module and a language-primitive attention (LPA) module to exchange information among all primitives and the language expression, respectively. The proposed CPA and LPA help the network find appropriate weights for primitive masks, so as to recover the target object. Extensive experiments have proven the effectiveness of our design and verified that the proposed network outperforms current state-of-the-art referring segmentation methods on three RefCOCO datasets.
Perceptual (roots of) core knowledge
Authors: Scholl Brian J. 
Published: June 2024

Abstract
Some core knowledge may be rooted in – or even identical to – well-characterized mechanisms of mid-level visual perception and attention. In the decades since it was first proposed, this possibility has inspired (and has been supported by) several discoveries in both infant cognition and adult perception, but it also faces several challenges. To what degree does What Babies Know reflect how babies see and attend?
Hydrogen Isotope Fingerprinting of Lipid Biomarkers in the Chinese Marginal Seas
Authors: Li Li , Sachs Julian P. , Yu Meng , Tao Shuqin , Wolhowe Matthew , Eglinton Timothy I. , Zhao Meixun 
Published: June 2024

AbstractThe hydrogen isotope ratio (δ2H) of lipid biomarkers from phytoplankton and terrestrial plants were measured in surface sediments from Chinese marginal seas (CMS), in order to evaluate processes affecting their spatial distribution, and by extension, the controls on organic carbon cycling in these dynamic marginal seas. The dinoflagellate sterol dinosterol and the microalgal sterol brassicasterol had low δ2H values (<−300%) near the mouth of the Yangtze River. Near the mouth of the Yellow River, dinosterol again had low δ2H values but brassicasterol had intermediate (−292 to −281%) δ2H values. This discrepancy in the δ2H values of two phytoplankton sterols may be explained by the timing of dinoflagellate production relative to that of brassicasterol producers (e.g., diatoms). The δ2H values of C16:0 fatty acid, synthesized by all organisms, had intermediate δ2H values (−199 to −178%) near the Yangtze River and lowest δ2H C16:0 values (−216 to −206%) occurred near the old Yellow River delta. The lowest δ2H C28:0 values (<−184%) occurred adjacent to rivers, suggesting that leaf‐wax lipids produced on the loess plateau, which are enriched in 2H, may contribute less to the nearshore environment than the offshore regions. Higher δ2H C28:0 values offshore may be explained by a larger contribution of leaf wax fatty acids from aerosols relative to river‐borne suspended particles. Lipid biomarker δ2H fingerprinting thus provides a new tool for deciphering the controls on organic carbon cycling and accumulation in the dynamic CMS.
Dome Craters on Ganymede and Callisto May Form by Topographic Relaxation of Pit Craters Aided by Remnant Impact Heat
Authors: Caussi M. L. , Dombard A. J. , Korycansky D. G. , White O. L. , Moore J. M. , Schenk P. M. 
Published: June 2024

AbstractThe icy Galilean satellites display impact crater morphologies that are rare in the Solar System. They deviate from the archetypal sequence of crater morphologies as a function of size found on rocky bodies and other icy satellites: they exhibit central pits in place of peaks, followed by central dome craters, anomalous dome craters, penepalimpsests, palimpsests, and multi‐ring structures. Understanding the origin of these features will provide insight into the geophysical factors that operate within the icy Galilean satellites. Pit craters above a size threshold feature domes. This trend, and the similarity in morphology between the two classes, suggest a genetic link between pit and dome craters. We propose that dome craters evolve from pit craters through topographic relaxation, facilitated by remnant heat from the impact. Our finite element simulations show that, for the specific crater sizes where we see domes on Ganymede and Callisto, domes form from pit craters within 10 Myr. Topographic relaxation eliminates the stresses induced by crater topography and restores a flat surface: ice flows downwards from the rim and upwards from the crater depression driven by gravity. When the starting topography is a pit crater, the heat left over from the impact is concentrated below the pit. Since warm ice flows more rapidly, the upward flow is enhanced beneath the pit, leading to the emergence of a dome. Given the timescales and the dependence on heat flux, this model could be used to constrain the thermal history and evolution of these moons.
Effects of basic carbohydrate counting versus standard dietary care for glycaemic control in type 2 diabetes (The BCC Study): a randomised, controlled trial
Authors: Ewers Bettina , Blond Martin B. , Bruun Jens M. , Vilsbøll Tina 
Published: June 2024

Abstract
Background
Clinical guidelines recommend basic carbohydrate counting (BCC), or similar methods to improve carbohydrate estimation skills and to strive for higher consistency in carbohydrate intake potentially improving glycaemic control. However, evidence for this approach in type 2 diabetes (T2D) is limited.

Objective
To examine the efficacy of a structured education program in BCC as add-on to standard dietary care on glycaemic control in individuals with T2D.

Methods
The BCC Study was a randomized, controlled, open-label, parallel-group trial. Individuals with T2D aged 18-75 years with glycated haemoglobin A1c (HbA1c) 53–97 mmol/mol (7.0–11.0%) were randomly assigned (1:1) to BCC or standard dietary care. The primary outcomes were differences in changes in HbA1c or glycaemic variability (calculated as mean amplitude of glycaemic excursions [MAGE]) between groups after six months of intervention.

Results
Between September 2018 and July 2021, 48 participants were randomly assigned, 23 to BCC and 25 to standard dietary care. Seven participants did not receive the allocated intervention. From a baseline-adjusted mean of 65 mmol/mol (95% CI 62-68 [8.1%, 7.8-8.4]), HbA1c changed by −5 mmol/mol (−8 to −1 [−0.5%, −0.7 to −0.1]) in BCC and -3 mmol/mol (−7 to 1 [−0.3%, −0.6 to 0.1]) in standard care with an estimated treatment effect of −2 mmol/mol (−7 to 4 [−0.2%, −0.6 to 0.4]); p = 0.554. From a baseline-adjusted mean of 4.2 mmol/l (3.7 to 4.8), MAGE changed by −16% (−33 to 5) in BCC and by −3% (−21 to 20) in standard care with an estimated treatment effect of −14% (−36 to 16); p = 0.319. Only median carbohydrate estimation error in favour of BCC (estimated treatment difference −55% (−70 to −32); p < 0.001) remained significant after multiple testing adjustment.

Conclusions
No glycaemic effects were found but incorporating BCC as a supplementary component to standard dietary care led to improved skills in estimating carbohydrate intake among individuals with T2D.
Healthy lifestyle and cognitive decline in middle-aged and older adults residing in 14 European countries
Authors: Bloomberg Mikaela , Muniz-Terrera Graciela , Brocklebank Laura , Steptoe Andrew 
Published: June 2024

AbstractStudies examining lifestyle and cognitive decline often use healthy lifestyle indices, making it difficult to understand implications for interventions. We examined associations of 16 lifestyles with cognitive decline. Data from 32,033 cognitively-healthy adults aged 50-104 years participating in prospective cohort studies of aging from 14 European countries were used to examine associations of lifestyle with memory and fluency decline over 10 years. The reference lifestyle comprised not smoking, no-to-moderate alcohol consumption, weekly moderate-plus-vigorous physical activity, and weekly social contact. We found that memory and fluency decline was generally similar for non-smoking lifestyles. By contrast, memory scores declined up to 0.17 standard deviations (95% confidence interval= 0.08 – 0.27) and fluency scores up to 0.16 standard deviations (0.07 – 0.25) more over 10 years for those reporting smoking lifestyles compared with the reference lifestyle. We thus show that differences in cognitive decline between lifestyles were primarily dependent on smoking status.
CapTrap-seq: a platform-agnostic and quantitative approach for high-fidelity full-length RNA sequencing
Authors: Carbonell-Sala Sílvia , Perteghella Tamara , Lagarde Julien , Nishiyori Hiromi , Palumbo Emilio , Arnan Carme , Takahashi Hazuki , Carninci Piero , Uszczynska-Ratajczak Barbara , Guigó Roderic 
Published: June 2024

AbstractLong-read RNA sequencing is essential to produce accurate and exhaustive annotation of eukaryotic genomes. Despite advancements in throughput and accuracy, achieving reliable end-to-end identification of RNA transcripts remains a challenge for long-read sequencing methods. To address this limitation, we develop CapTrap-seq, a cDNA library preparation method, which combines the Cap-trapping strategy with oligo(dT) priming to detect 5’ capped, full-length transcripts. In our study, we evaluate the performance of CapTrap-seq alongside other widely used RNA-seq library preparation protocols in human and mouse tissues, employing both ONT and PacBio sequencing technologies. To explore the quantitative capabilities of CapTrap-seq and its accuracy in reconstructing full-length RNA molecules, we implement a capping strategy for synthetic RNA spike-in sequences that mimics the natural 5’cap formation. Our benchmarks, incorporating the Long-read RNA-seq Genome Annotation Assessment Project (LRGASP) data, demonstrate that CapTrap-seq is a competitive, platform-agnostic RNA library preparation method for generating full-length transcript sequences.
Structural basis for recruitment of peptidoglycan endopeptidase MepS by lipoprotein NlpI
Authors: Wang Shen , Huang Chun-Hsiang , Lin Te-Sheng , Yeh Yi-Qi , Fan Yun-Sheng , Wang Si-Wei , Tseng Hsi-Ching , Huang Shing-Jong , Chang Yu-Yang , Jeng U-Ser , Chang Chung-I , Tzeng Shiou-Ru 
Published: June 2024

AbstractPeptidoglycan (PG) sacculi surround the cytoplasmic membrane, maintaining cell integrity by withstanding internal turgor pressure. During cell growth, PG endopeptidases cleave the crosslinks of the fully closed sacculi, allowing for the incorporation of new glycan strands and expansion of the peptidoglycan mesh. Outer-membrane-anchored NlpI associates with hydrolases and synthases near PG synthesis complexes, facilitating spatially close PG hydrolysis. Here, we present the structure of adaptor NlpI in complex with the endopeptidase MepS, revealing atomic details of how NlpI recruits multiple MepS molecules and subsequently influences PG expansion. NlpI binding elicits a disorder-to-order transition in the intrinsically disordered N-terminal of MepS, concomitantly promoting the dimerization of monomeric MepS. This results in the alignment of two asymmetric MepS dimers respectively located on the two opposite sides of the dimerization interface of NlpI, thus enhancing MepS activity in PG hydrolysis. Notably, the protein level of MepS is primarily modulated by the tail-specific protease Prc, which is known to interact with NlpI. The structure of the Prc-NlpI-MepS complex demonstrates that NlpI brings together MepS and Prc, leading to the efficient MepS degradation by Prc. Collectively, our results provide structural insights into the NlpI-enabled avidity effect of cellular endopeptidases and NlpI-directed MepS degradation by Prc.
The crucial role of circular waste management systems in cutting waste leakage into aquatic environments
Authors: Gómez-Sanabria Adriana , Lindl Florian 
Published: June 2024

AbstractWaste leakage has become a major global concern owing to the negative impacts on aquatic ecosystems and human health. We combine spatial analysis with the Shared Socioeconomic Pathways to project future waste leakage under current conditions and develop mitigation strategies up to 2040. Here we show that the majority (70%) of potential leakage of municipal solid waste into aquatic environments occurs in China, South Asia, Africa, and India. We show the need for the adoption of active mitigation strategies, in particular circular waste management systems, that could stop waste from entering the aquatic ecosystems in the first place. However, even in a scenario representing a sustainable world in which technical, social, and financial barriers are overcome and public awareness and participation to rapidly increase waste collection rates, reduce, reuse and recycling waste exist, it would be impossible to entirely eliminate waste leakage before 2030, failing to meet the waste-related Sustainable Development Goals.