bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Preparation of C2‐Symmetric Allenes by Palladium‐Catalyzed Double‐Nucleophilic Substitution on 3‐Bromopenta‐2,4‐dienyl Acetate.
Authors: Ogasawara Masamichi , Suzuki Mayuka , Takahashi Tamotsu 
Published: September 2012

AbstractIn the presence of chiral ligands optically active allenes are available.
ChemInform Abstract: Methyl 2,2‐Difluoro‐2‐(fluorosulfonyl)acetate, a Difluorocarbene Reagent with Reactivity Comparable to that of Trimethylsilyl 2,2‐Difluoro‐2‐(fluorosulfonyl)acetate (TFDA).
Authors: Eusterwiemann Steffen , Martinez Henry , Dolbier William R. Jr. 
Published: September 2012

AbstractThe title acetate (II) is found to be an efficient difluorocarbene source.
ChemInform Abstract: Tetramethylnorbornadiene, a Versatile Alkene for Cyclopentenone Synthesis Through Intermolecular Pauson—Khand Reactions.
Authors: Reves Marc , Lledo Agusti , Ji Yining , Blasi Emma , Riera Antoni , Verdaguer Xavier 
Published: September 2012

AbstractA number of substituted cyclopentenones can be prepared by this convenient method.
ChemInform Abstract: Reduction of Nitroarenes to Azoxybenzenes by NaOH—PEG 400.
Authors: Liu Yufang , Liu Bo , Guo Ailing , Dong Zhenming , Jin Shuo , Lu Yun 
Published: September 2012

AbstractOn refluxing nitroarenes with NaOH and PEG 400 in benzene varying yields of the corresponding azoxybenzenes are obtained.
ChemInform Abstract: Comparative Study on Reducing Aromatic Aldehydes by Using Ammonia Borane and Lithium Amidoborane as Reducing Reagents.
Authors: Xu Weiliang , Fan Hongjun , Wu Guotao , Chen Ping 
Published: September 2012

AbstractThe reduction of aromatic aldehydes with ammonia borane proceeds with hydrogen transfer from both the ammonia and the borane to directly give the corresponding benzylic alcohols (II).
ChemInform Abstract: Enantioselective Rhodium‐Catalyzed Allylic Alkylation of Acyclic α‐Alkoxy Substituted Ketones Using a Chiral Monodentate Phosphite Ligand.
Authors: Evans P. Andrew , Clizbe Elizabeth A. , Lawler Michael J. , Oliver Samuel 
Published: September 2012

AbstractThe first example of the title reaction is presented.
ChemInform Abstract: Rhodium‐Catalyzed Linear‐Selective Alkyne Hydroacylation.
Authors: Poingdestre Sarah‐Jane , Goodacre Jonathan D. , Weller Andrew S. , Willis Michael C. 
Published: September 2012

AbstractA highly linear‐selective alkyne hydroacylation protocol, covering a range of electron‐rich and electron‐poor aromatic aldehydes, alkyl aldehydes, and enal substrates, is reported.
ChemInform Abstract: Silver(I)‐Catalyzed Carboxylation of Arylboronic Esters with CO2.
Authors: Zhang Xiao , Zhang Wen‐Zhen , Shi Ling‐Long , Guo Chun‐Xiao , Zhang Ling‐Ling , Lu Xiao‐Bing 
Published: September 2012

AbstractThe catalytic system presented shows a wide functional group compatibility as demonstrated by 31 examples.
ChemInform Abstract: Preparation of Tertiary Amides via Aryl, Heteroaryl, and Benzyl Organozinc Reagents: Scope and Limitations.
Authors: Rieke Reuben D. , Kim Seung‐Hoi 
Published: September 2012

AbstractVarious (het)aryl‐ and benzylzinc halides react successfully with the carbamoyl chlorides (II) and (XIII).
ChemInform Abstract: ZrCl4‐Catalyzed Synthesis of β‐Aminosulfides from Aziridines and Thiols.
Authors: Movassagh Barahman , Rakhshani Amir 
Published: September 2012

AbstractThe zirconium tetrachloride‐promoted ring‐opening of N‐tosylaziridines with thiols is studied.
ChemInform Abstract: Efficient Synthesis of Urea Derivatives via a Sequential One‐Pot Nucleophilic Addition/Ugi Five‐Component Reaction under Solvent‐Free Conditions.
Authors: Azizian Javad , Yadollahzadeh Khadijeh , Tahermansouri Hasan , Khoei Davood Chobfrosh , Delbari Akram Sadat 
Published: September 2012

AbstractPolyfunctionalized aromatic urea derivatives (VI) are synthesized via novel one‐pot, five component nucleophilic addition—Ugi reaction sequence.
ChemInform Abstract: Pd(PPh3)4/AgOAc‐Catalyzed One‐Pot Synthesis of Substituted 3,4‐Dihydronaphthalen‐1(2H)‐ones.
Authors: Liu Hui , Yan Peiyun , Li Yan , Liu Jinliang , Sun Qian , Wang Xingbin , Wang Cunde 
Published: September 2012

Abstractvia reaction of 2‐iodocyclohex‐2‐ones (I) with alkynes (II)
ChemInform Abstract: Lewis Acid‐Mediated Domino Reaction of 3‐Bromomethylthiophenes with Arenes/Heteroarenes.
Authors: Dhayalan Vasudevan , Mohanakrishnan Arasambattu K. 
Published: September 2012

AbstractA suitable domino mechanism for the formation of annulated heterocycles is proposed involving arylation followed by intramolecular cyclization and subsequent aromatization.
ChemInform Abstract: Reactions of Tetracyanocyclopropyl Ketones with Ammonia and Primary Amines.
Authors: Kayukov Ya. S. , Karpov S. V. , Bardasov I. N. , Ershov O. V. , Belikov M. Yu. , Nasakin O. E. , Kayukova O. V. 
Published: September 2012

AbstractReaction of title compounds (I) with ammonia affords products (II) with conservation of the three‐membered ring, whereas reaction with amines (III) is accompanied by ring opening [→ (IV)] and successive heterocyclization furnishing pyrrolopyrrole derivatives (V).
ChemInform Abstract: Montmorillonite K‐10 Catalyzed, Microwave‐Assisted Cyclization of Acetylenic Amines: An Efficient Synthesis of Pyrrolocoumarins and Pyrroloquinolones.
Authors: Majumdar K. C. , Ponra Sudipta , Ghosh Tapas 
Published: September 2012

AbstractNotable features include short reaction times, high yields, and a convenient solvent‐free procedure.
ChemInform Abstract: Synthesis of Fluorine Containing N‐Heterocycles Using Oxides of Terminal Perfluoroolefins and Urea.
Authors: Saloutina Lyudmila V. , Zapevalov Aleksandr Ya. , Kodess Mikhail I. , Slepukhin Pavel A. , Saloutin Victor I. , Chupakhin Oleg N. 
Published: September 2012

AbstractThe unexpected formation of fluorine containing heterocycles (III), (V), (VI), or (IX) from the reaction of perfluoroalkyl‐substituted perfluorooxiranes with urea is studied under different reaction conditions.
ChemInform Abstract: Synthesis of 2,3‐Diaryl‐5H‐imidazo[2,1‐a]isoindol‐5‐ones via the One‐Pot Reaction of 1,2‐Diketones, 2‐Formylbenzoic Acids, and Ammonium Acetate.
Authors: Hosseini‐Zare Maryam Sadat , Mahdavi Mohammad , Saeedi Mina , Asadi Mehdi , Javanshir Shahrzad , Shafiee Abbas , Foroumadi Alireza 
Published: September 2012

AbstractA simple protocol is developed which affords the target compounds in good yields without the need for any catalyst.
ChemInform Abstract: Generation of Benzoimidazo[1,5‐a]imidazoles via a Copper‐Catalyzed Tandem Reaction of Carbodiimide and Isocyanoacetate.
Authors: Qiu Guanyinsheng , Wu Jie 
Published: September 2012

AbstractThe reaction proceeds through a formal [3 + 2] cycloaddition and C‐N coupling.
ChemInform Abstract: Convenient Synthesis of an Isoxazole Compound, KRIBB3, as an Anticancer Agent.
Authors: Lee Hyeong Kyu , Yun Eunju , Min Ji Hye , Yoon Kab Seog , Choung Dong‐Ho , Lee Sangku 
Published: September 2012

AbstractKRIBB3 (XI), which exhibits strong antimigratory and antimitotic activities against cancer cells, is prepared in a practical synthetic way.
ChemInform Abstract: Debenzylation of Functionalized 4‐ and 5‐Substituted 1,2,3‐Triazoles.
Authors: Farooq Tahir , Sydnes Leiv K. , Toernroos Karl W. , Haug Bengt Erik 
Published: September 2012

AbstractC‐Monosubstituted NH‐1,2,3‐triazoles can be efficiently prepared by debenzylation of the corresponding N‐benzyl 1,4‐ or 1,5‐disubstituted derivatives (III) and (V).
ChemInform Abstract: Metal‐Free Phosphorylations of 1,3,4‐Oxadiazoles and Related Heterocycles.
Authors: Zou Liang‐Hua , Dong Zhi‐Bing , Bolm Carsten 
Published: September 2012

Abstract2‐Substituted 1,3,4‐oxadiazoles are phosphorylated at C‐5.
ChemInform Abstract: A Novel Method for the Synthesis of 5‐Substituted 1H‐Tetrazole from Oxime and Sodium Azide.
Authors: Patil Umakant B. , Kumthekar Kedar R. , Nagarkar Jayashree M. 
Published: September 2012

AbstractA simple protocol is developed for the copper catalyzed reaction of oximes with sodium azide to yield tetrazole derivatives (II) (15 examples).
ChemInform Abstract: Regioisomeric Oximes and Thiosemicarbazones Derived from 6‐Substituted Pyridoxines.
Authors: Shtyrlin Nikita V. , Lodochnikova Olga A. , Shtyrlin Yurii G. 
Published: September 2012

AbstractA new approach for the regioselective oxidation of the hydroxymethyl groups in 6‐methyl‐2,3,4‐tris(hydroxymethyl)pyridin‐5‐ol and the conversion of the aldehydes obtained into corresponding oximes and thiosemicarbazones is given.
ChemInform Abstract: Expedient N‐Arylation for the Synthesis of 2‐Arylamino‐3‐cyanopyridines Using Ionic Copper(I) Complex as a Catalyst.
Authors: Zhang Min , Xiong Biao , Wang Ting , Wang Xiaoting , Yan Fengxia , Ding Yuqiang 
Published: September 2012

AbstractThis is the first report about Ullmann‐type N‐arylation of 2‐amino‐cyanopyridines (I) with aryl halides using a bis(phenanthroline)—copper(I) complex as catalyst.
ChemInform Abstract: Reactions of Ethyl 1‐Benzylidene‐7a‐hydroxy‐4‐phenyl‐6‐oxo‐octahydro‐1H‐indene‐5‐carboxylat e and Ethyl 5‐Benzylidene‐4a‐hydroxy‐1‐phenyl‐3‐oxodecahydronaphthalene‐2‐carboxylat e with1,2,4‐Triazol‐3‐amine. Synthesis of Substituted Triazoloquinazolines.
Authors: Gulai T. V. , Golikov A. G. 
Published: September 2012

AbstractThe title reaction results in the formation of linear and angular triazoloquinazoline regioisomers, which can be regarded as structural analogues of tetracycline antibiotics.
ChemInform Abstract: Organogelators Derived from [3,3]Metacyclophane Skeleton with a Urea Unit.
Authors: Tsuge Akihiko , Matsushita Ryuichiro , Sakura Katsuhiko , Moriguchi Tetsuji , Araki Koji 
Published: September 2012

AbstractDithia[3,3]metacyclophanes (I) give stable organogels in cyclohexane.
ChemInform Abstract: Synthesis and Antioxidant Activity of (5E,9E)‐16‐(Substituted)‐7,8‐dihydro‐16λ5‐dibenzo [d,l][1,3,7,10,2]dioxadiazaphosphacyclotridecine‐16‐ones.
Authors: Reddy Chinta Raveendra , Rani Chinthaparthi Radha , Sekhar Kuruva Chandra , Reddy Gangireddy Chandra Sekhar , Raju Chamarthi Naga 
Published: September 2012

AbstractA new class of biologically active 13‐membered phosphorus‐macrocycles are conveniently synthesized from 1,2‐bis(salicylidene amino)phenylene (I).
ChemInform Abstract: A Partial Synthesis of 23‐Hydroxybetulonic Acid and 23‐Hydroxybetulinic Acid Starting from Betulinic Acid.
Authors: Sun Fei , Zhu Peiqing , Yao Hequan , Wu Xiaoming , Xu Jinyi 
Published: September 2012

AbstractBetulinic acid (I) is used in the traditional Chinese medicine for the treatment of amoebic dysentery and malaria.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Functionalized α,α‐Disubstituted α‐Amino Acid Derivatives from Racemic Unprotected α‐Amino Acids via in situ Generated Azlactones.
Authors: Weber Manuel , Frey Wolfgang , Peters Rene 
Published: September 2012

AbstractTandem reaction of 5 steps affords the highly enantioenriched target compounds.
ChemInform Abstract: A Simple Approach for the Synthesis of Thio‐, Dithio‐, and Selenothiocarbamate‐Tethered Peptidomimetics.
Authors: Lalithamba H. S. , Vishwanatha T. M. , Reddy M. Samarasimha , Sureshbabu Vommina V. 
Published: September 2012

AbstractNucleophilic coupling of amino thiols with isocyanates, isothiocyanates, or isoselenocyanates provides a facile method for the synthesis of the title compounds.
ChemInform Abstract: Tuning Glycosidase Inhibition Through Aglycone Interactions: Pharmacological Chaperones for Fabry Disease and GM1 Gangliosidosis.
Authors: Ortiz Mellet C. , et al. et al. 
Published: September 2012

AbstractIminosugar derivatives (I) show a potent and selective inhibition of human lysosomal α‐galactosidase, whilst bicyclic galactomimetics (II) demonstrate a selective inhibition of β‐galactosidase.
ChemInform Abstract: Nitro Group as a New Anchoring Group for Organic Dyes in Dye‐Sensitized Solar Cells.
Authors: Cong Jiayan , Yang Xichuan , Liu Jing , Zhao Jinxia , Hao Yan , Wang Yu , Sun Licheng 
Published: September 2012

AbstractAn interesting phenomenon is found for DSCs fabricated with dye (I).
A Family of Nonparametric Density Estimation Algorithms
Authors: Tabak E. G. , Turner Cristina V. 
Published: September 2012

AbstractA new methodology for density estimation is proposed. The methodology, which builds on the one developed by Tabak and Vanden‐Eijnden, normalizes the data points through the composition of simple maps. The parameters of each map are determined through the maximization of a local quadratic approximation to the log‐likelihood. Various candidates for the elementary maps of each step are proposed; criteria for choosing one includes robustness, computational simplicity, and good behavior in high‐dimensional settings. A good choice is that of localized radial expansions, which depend on a single parameter: all the complexity of arbitrary, possibly convoluted probability densities can be built through the composition of such simple maps. © 2012 Wiley Periodicals, Inc.
Reverse Vesicles of Ferrum Laurate Metallosurfactant in Non‐Aqueous Solution Dried to Produce Solid Shells
Authors: Dong Renhao , Hao Jingcheng 
Published: September 2012

AbstractFerrum laurate [Fe(OOCC11H23)3] metallosurfactant can successfully self‐assemble into reversed vesicles in organic media such as pure CHCl3 and a mixed solvent of CHCl3 and CH3OH. Deformed solid vesicles, including collapsed erythrocyte‐like and broken hollow shells, were obtained directly by slectively drying the organic solvents. The morphology of the reversed vesicles of metallosurfactant in the organic media to hardly solid shells is maintained and it is ascribed to the evaporation rate of the solvents and the interactions between ferrum laurate and solvents.
Structure and Bonding of Tetracyanopyrrolides
Authors: Becker Martin , Harloff Jörg , Jantz Thomas , Schulz Axel , Villinger Alexander 
Published: September 2012

AbstractSalts bearing the tetracyanopyrrolide anion (TCP) were synthesized from tetracyano‐1,4‐dithiin and sodium azide according to a modified synthetic protocol. The solid‐state structures of HTCP, MeTCP, Me4NTCP, NaTCP, and the ionic liquid EMIMTCP (EMIM = 1‐ethyl‐3‐methylimidazolium) are discussed for the first time. According to experimental and computational data, the TCP anion can be regarded as a pseudohalide with π bonds highly delocalized over the entire anion including the four cyano groups. The planar anion is C2v symmetric and represents a multifunctional binary CN ligand, which is capable of forming classic coordination bonds through the lone pairs of the CN groups or the ring nitrogen atom. In addition, noncovalent interactions such as π–π interactions are found and can be used to strengthen structural and electronic communication between organic ligands.
Plasma amisulpride in relation to prescribed dose, clozapine augmentation, and other factors: data from a therapeutic drug monitoring service, 2002–2010
Authors: Bowskill Sally V. J. , Patel Maxine X. , Handley Simon A. , Flanagan Robert J. 
Published: September 2012

ObjectiveThis study aimed to investigate the effect of dose and other factors on plasma amisulpride concentrations in clinical practice.MethodAmisulpride therapeutic drug monitoring data 2002–2010 have been studied.ResultsThere were 296 samples (196 adult patients). Amisulpride was not detected in 10% of samples. In the remainder, the mean plasma amisulpride in relation to the prescribed dose (mg/day) was as follows: 100–200 (111 µg/L), 201–400 (254 µg/L), 400–800 (421 µg/L), and 800–1200 (494 µg/L). For prescribed doses up to 800 mg/day, only 51% of results were within 100–319 µg/L. There were no significant sex differences in mean plasma amisulpride or mean dose. The mean plasma amisulpride, but not the dose, was significantly higher in smokers. Linear regression analysis showed that dose explained only 42% of the variation in plasma amisulpride after log10 transformation of both variables. There was no significant difference in the mean dose or mean plasma amisulpride in patients co‐prescribed clozapine as compared with the remaining samples.ConclusionIn practice, dose is a poor predictor of plasma amisulpride concentration. Therapeutic drug monitoring may not only help assess adherence, but also guide dosage. Copyright © 2012 John Wiley & Sons, Ltd.
Metabolic syndrome in psychiatrically hospitalized patients treated with antipsychotics and other psychotropics
Authors: Centorrino Franca , Masters Grace A. , Talamo Alessandra , Baldessarini Ross J. , Öngür Dost 
Published: September 2012

ObjectiveWe evaluated prevalence and risk factors for metabolic syndrome in inpatients treated with antipsychotics, with or without other psychotropic drugs. Although the literature on metabolic syndrome in psychiatry has expanded in recent years, we seek to elucidate some of the remaining gaps by examining a severely and chronically ill population heavily treated with pharmacological agents.MethodsWith data from medical records of 589 adults hospitalized at McLean Hospital in 2010 and 2011, we used standard statistical analyses to characterize risks and covariates of metabolic syndrome.ResultsWith prior antipsychotic treatment, prevalence of metabolic syndrome was 29.5%. The syndrome was strongly associated with being overweight (≥25 kg/m2 in 60.1% of subjects), older age, longer treatment‐exposure, schizoaffective diagnosis (39.8%), more illness‐episodes or hospitalizations, polytherapy, and higher total daily chlorpromazine‐equivalent doses, but not sex. Notably, metabolic syndrome risk was greater among young, antipsychotic treated patients (15.5‐fold at age ≤25 years).ConclusionsThe findings extend information on the association of metabolic syndrome with antipsychotic treatment. Metabolic syndrome was found in 30% of antipsychotic‐exposed inpatients. Risk was surprisingly high in young persons and after brief treatment‐exposure, and psychotropic polytherapy increased risk. Copyright © 2012 John Wiley & Sons, Ltd.
ANALYSIS OF SPATIAL VARIABILITY FOR STORMWATER CAPTURE TANK ASSESSMENT
Authors: De Paola Francesco , Ranucci Antonio 
Published: September 2012

ABSTRACTStormwater tank design and installation is one of the most suitable actions to undertake as a strategy for the quantity and quality control of surface urban runoff during a rain event.In the present work, the quality efficiency of a stormwater capture tank in a sewer system serving a typical Italian urban catchment is analysed on a probabilistic basis, mainly with reference to rainfall space variability on the Tyrrhenian coast side of Italy.In particular, two probabilistic approaches (a simple and a Copula function‐based one) are applied to estimate the average efficiency of such a device to reduce the outflow pollution load into the receiver, varying the net capture tank volume from 0 (when only a combined sewer overflow, CSO, is present) up to 100 m3 per impervious catchment hectare.In this way, simple expressions to be used for a preliminary sizing of the capacity of a capture tank, without performing complex computational continuous simulations, are provided. Copyright © 2012 John Wiley & Sons, Ltd.
Metabolic profiling reveals disorder of carbohydrate metabolism in mouse fibroblast cells induced by titanium dioxide nanoparticles
Authors: Jin Chengyu , Liu Yumin , Sun Limin , Chen Tianlu , Zhang Yinan , Zhao Aihua , Wang Xiaoyan , Cristau Melanie , Wang Kaisheng , Jia Wei 
Published: September 2012

ABSTRACTAs titanium dioxide (TiO2) nanoparticles are widely used commercially, their potential biosafety and metabolic mechanism needs to be fully explained. In this study, the cytotoxicity of homogeneous and weakly aggregated (< 100 nm) TiO2 nanoparticles was investigated by analyzing the changes in metabolite profiles both in mouse fibroblast (L929) cells and their corresponding culture media using gas chromatograph with a time‐of‐flight mass spectrometry (GC/TOFMS)‐based metabolomic strategy. With multivariate statistics analysis, satisfactory separations were observed in principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS‐DA) models. Based on the variable importance in the OPLS‐DA models, a series of differential metabolites were identified by comparison between TiO2 nanoparticle‐treated L929 cells or their corresponding culture media and the control groups. It was found that the major biochemical metabolism (carbohydrate metabolism) was suppressed in TiO2 nanoparticle‐treated L929 cells and their corresponding culture media. These results might account for the serious damage to energy metabolism in mitochondria and the increased cellular oxidation stress in TiO2 nanoparticle‐induced L929 cells. These results also suggest that the metabolomic strategy had a great potential in evaluating the cytotoxicity of TiO2 nanoparticles and thus was very helpful in understanding its underlying molecular mechanisms. Copyright © 2012 John Wiley & Sons, Ltd.
A fast parallel clustering algorithm for molecular simulation trajectories
Authors: Zhao Yutong , Sheong Fu Kit , Sun Jian , Sander Pedro , Huang Xuhui 
Published: September 2012

AbstractWe implemented a GPU‐powered parallel k‐centers algorithm to perform clustering on the conformations of molecular dynamics (MD) simulations. The algorithm is up to two orders of magnitude faster than the CPU implementation. We tested our algorithm on four protein MD simulation datasets ranging from the small Alanine Dipeptide to a 370‐residue Maltose Binding Protein (MBP). It is capable of grouping 250,000 conformations of the MBP into 4000 clusters within 40 seconds. To achieve this, we effectively parallelized the code on the GPU and utilize the triangle inequality of metric spaces. Furthermore, the algorithm's running time is linear with respect to the number of cluster centers. In addition, we found the triangle inequality to be less effective in higher dimensions and provide a mathematical rationale. Finally, using Alanine Dipeptide as an example, we show a strong correlation between cluster populations resulting from the k‐centers algorithm and the underlying density. © 2012 Wiley Periodicals, Inc.
Professional collaboration to achieve FASHRM and DFASHRM recognition
Authors: Bunting Robert F. , Benton Joyce 
Published: September 2012

AbstractMembers of the American Society for Healthcare Risk Management (ASHRM) are undeniably talented. They also share a spirit of volunteerism. Two ASHRM committees are fostering further member collaboration to provide individual growth, enhance educational offerings for members, and strengthen the organization's journal. Though 26% of ASHRM members have attained the CPHRM credential, only 2.5% of ASHRM members have attained a fellow designation. Primary barriers to attaining a fellow designation are the requirements for continuing education and contributions to the risk management field. The organization's Journal Editorial Review Board, in concert with its Annual Conference & Exhibition Committee, encourages members to explore opportunities to write for the Journal, speak at the annual conference, and attain one of the organization's professional designations. In addition, the Barton Certificate Program in Healthcare Risk Management promotes professional development with sessions taught on this topic for new and experienced risk managers.
An enterprise look at mHealth
Authors: Boisvert Sue 
Published: September 2012

AbstractThe theme of this year's annual American Society for Healthcare Risk Management conference is Getting to Zero™: the Power of One™. The widespread use of mHealth exemplifies the power of one. The power of one user to apply technology to change the way healthcare is delivered at the bedside, in the provider's office, and in the patient's home. The power of one organization to provide technology that ensures provider access to clinical information to improve decision making, facilitate access to clinical information, and provide new ways to partner with patients — wherever they may be. This article provides an overview of the current status of mHealth and describes risk management strategies appropriate for organizations of all sizes and complexities.