bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of surgery in the treatment of pediatric low-grade glioma with various degrees of brain stem involvement
Authors: Lorincz Katalin Nora , Gorodezki David , Schittenhelm Jens , Zipfel Julian , Tellermann Jonas , Tatagiba Marcos , Ebinger Martin , Schuhmann Martin Ulrich 
Published: August 2024

Abstract
Objective
Posterior fossa pediatric low-grade glioma involving the brainstem and cerebellar peduncles (BS-pLGG) are a subgroup with higher risks at surgery. We retrospectively analyzed the role of surgery in the interdisciplinary armamentarium of treatment options in our institutional series of BS-pLGG with various degrees of brainstem involvement.

Material and methods
We analyzed data of 52 children with BS-pLGG after surgical intervention for clinical/molecular characteristics, neurological outcome, factors influencing recurrence/progression pattern, and tumor volumetric analysis of exclusively surgically treated patients to calculate tumor growth velocity (TGV). Tumors were stratified according to primary tumor origin in four groups: (1) cerebellar peduncle, (2) 4th ventricle, (3) pons, (4) medulla oblongata.

Results
The mean FU was 6.44 years. Overall survival was 98%. The mean PFS was 34.07 months. Two patients had biopsies only. Fifty-two percent of patients underwent remission or remained in stable disease (SD) after initial surgery. Patients with progression underwent further 23 resections, 15 chemotherapies, 4 targeted treatments, and 2 proton radiations. TGV decreased after the 2nd surgery compared to TGV after the 1st surgery (p < 0.05). The resection rates were significantly higher in Groups 1 and 2 and lowest in medulla oblongata tumors (Group 4) (p < 0.05). More extended resections were achieved in tumors with KIAA1549::BRAF fusion (p = 0.021), which mostly occurred in favorable locations (Groups 1 and 2). Thirty-one patients showed postoperatively new neurological deficits. A total of 27/31 improved within 12 months. At the end of FU, 6% had moderate deficits, 52% had mild deficits not affecting activities, and 36% had none. Fifty percent of patients were free of disease or showed remission, 38% were in SD, and 10% showed progression.

Conclusion
The first surgical intervention in BS-pLGG can control disease alone in overall 50% of cases, with rates differing greatly according to location (Groups 1 > 2 > 3 > 4), with acceptable low morbidity. The second look surgery is warranted except in medullary tumors. With multimodality treatments almost 90% of patients can obtain remission or stable disease after > 5 years of follow-up. An integrated multimodal and multidisciplinary approach aiming at minimal safe residual disease, combining surgery, chemo-, targeted therapy, and, as an exception, radiation therapy, is mandatory.
Social and emotional impact of anterior drooling in school-age children and young people with neurodevelopmental disabilities
Authors: Orriëns Lynn B. , van Aarle Lieke G. J. M. , Erasmus Corrie E. , van Hulst Karen , van der Burg Jan J. W. 
Published: August 2024

Abstract
Purpose
Anterior drooling is a common comorbidity in children and young people (CYP) with neurodevelopmental disabilities. This study aimed to assess the social and emotional impact of drooling in CYP with a developmental age (DA) of 6 years and older, in whom this impact may differ from those with a lower DA due to their developing sense of self and awareness of their position within social groups.

Methods
Questionnaire data collected for routine clinical care were used to assess parental perceptions of the impact of drooling on (1) social interaction; (2) satisfaction with social interaction, appearance, family relations and life in general and (3) the way CYP expressed feelings on appearance, acceptance by peers and acceptance by adults. Fisher’s exact tests and Mann–Whitney U tests were applied to identify associations between clinical characteristics and the social and emotional impact of drooling.

Results
Seventy-nine CYP with an estimated DA ≥ 6 years were included. The majority experienced frequent to constant (83%) and profuse (61%) drooling. Drooling frequently compromised social interaction with peers (49%) and adults (28%), and cognitive abilities were underestimated in 40%. Dissatisfaction with physical appearance (25%) related to drooling was noted. One-fifth of CYP reportedly expressed negative feelings on acceptance by peers related to drooling.
Conclusions: These findings underscore the substantial impact of drooling on CYP with a DA of 6 years and older, primarily through avoidance by peers and underestimated cognitive abilities, emphasizing that recognizing and addressing these social-emotional consequences should be integral to clinical care.

What is Known:• Anterior drooling is common among children and youth with neurodevelopmental disabilities.

What is New:• There seems to be a heightened prevalence of impaired social interaction with peers and underestimation of cognitive abilities due to drooling among children with a developmental age of at least 6 years compared to previous studies with more heterogeneous populations.• The impact of drooling can extend to domains that affect self-esteem, although this may not be fully captured with standardized questions, requiring clinicians to address these consequences in a way that is tailored to the child’s experiences.
Unravelling the evolution of a continental rift by a multi-proxy provenance study (Albertine Rift, Uganda)
Authors: Hinderer M. , Schneider S. , Stutenbecker L. 
Published: August 2024

AbstractSedimentary provenance analysis has rarely been applied to continental rifts, because source-rock terrains are assumed to be uniform and supply systems stable and closely connected to the formation of graben shoulders. Here, we test the suitability of multi-proxy sedimentary provenance analysis to unravel the evolution of a segment of the East African Rift System from its sedimentary record, where an extreme relief has been created and a continent-wide drainage system has been affected. Multi-proxy techniques include petrographic-mineralogical analysis (framework, heavy mineral spectra, zircon morphology, and colour), as well as single-grain garnet geochemistry, Zr-in-rutile thermometry, and geochronological methods (detrital zircon U–Pb ages). Published data are compiled and complemented by new U–Pb detrital zircon data of rift sediments. Because a comprehensive database of basement source-rock compositions from East Africa is missing, published modern river sand compositions have been added to provide endmember source fingerprints. The selected Albertine Rift is surrounded by four main source terrains within the East African Basement, which cannot be separated clearly by individual provenance indicators. Most useful were heavy mineral spectra, garnet composition, and with limitation Zr-in-rutile thermometry showing different metamorphic overprint. U–Pb detrital zircon spectra assisted well in detecting juvenile magmatism of different orogenic events, but repeated inheritance in younger units prevented a strict allocation. Petrographic maturity turned out to be more dependent on multi-cycle detritus as on climate shift. Applying endmember composition to rift sediments, three evolutionary stages of the Albertine Rift could be identified which coincide with basin-scale unconformities. Moreover, we could prove a large, southwest trending drainage network in East Africa during the Miocene, which was destructed step-wise by ongoing rifting. Extreme uplift of the Rwenzori Mountains up to 5109 m could be documented by a specific set of provenance indicators justified by modern river sand. Three main lessons can be drawn from this study: (1) basement units can be only reliably characterized by a combination of provenance-sensitive parameters, and here, the frequently used U–Pb detrital zircon ages are not sufficient; (2) it is possible to define subunits, e.g., individual fault-blocks within the rift; and (3) chemical weathering is unproblematic when applying a multi-parameter approach even in a tropical setting.
Graphical abstract
Analyzing effects on anterior open bite in twins by PLS-SEM and sobel test
Authors: Birant Sinem , Veznikli Mert , Kasimoglu Yelda , Koruyucu Mine , Evren Atıf Ahmet , Seymen Figen 
Published: August 2024

Abstract
Objective
This study aimed to assess the different pathways between predictor factors such as zygosity, atypical swallowing, mouth breathing, breastfeeding and bottle feeding related to anterior open bite (AOB) in twins.

Methods
The study was conducted in monozygotic (MZ) and dizygotic (DZ) twin children aged 3–15 years. AOB, atypical swallowing, mouth breathing, feeding type, duration of bottle use, and mouth opening status during sleep were recorded during oral examination. Partial least squares structural equation model (PLS-SEM) and sobel tests were performed to assess the total and indirect effects among the variables on AOB.

Results
A total of 404 children (29.2% MZ;70.8% DZ) participated in this study. The effect of zygosity on mouth breathing in the PLS-SEM model was statistically significant. Conversely, it was determined that mouth breathing effected that atypical swallowing (p = 0.001). Atypical swallowing triggered AOB (p = 0.001). The atypical swallowing has a mediation effect between AOB and mouth breathing (p = 0.020). Mouth breathing causes atypical swallowing and therefore indirectly increases the likelihood of AOB. While breastfeeding decreases AOB incidence (p = 0.023), bottle feeding increases AOB incidence (p = 0.046). The sobel tests show that the fully mediator variable feature of mouth breathing is statistically significant in the negative relation between zygosity and atypical swallowing.

Conclusion
The PLS-SEM model showed that mouth breathing triggers atypical swallowing and atypical swallowing triggers AOB. As a result of this chain of relationships, an indirect effect of zygosity on AOB was observed. According to sobel tests, zygosity has an indirect effect on atypical swallowing through mouth breathing, while mouth breathing has a positive indirect effect on AOB through atypical swallowing.

Clinical relevance
This study identified the relationships between different factors and the presence of AOB. The findings of this study demonstrate in detail the relationships between AOB and zygosity, atypical swallowing, mouth breathing, breastfeeding and bottle feeding. Brestfeeding has a reducing effect on the frequency of AOB. Among the nutritional forms, breastfeeding ensures the proper development of the stomatognathic system by working the oro-facial muscles.
Construction and Validation of a General Medical Image Dataset for Pretraining
Authors: Zhang Rongguo , Pei Chenhao , Shi Ji , Wang Shaokang 
Published: August 2024

AbstractIn the field of deep learning for medical image analysis, training models from scratch are often used and sometimes, transfer learning from pretrained parameters on ImageNet models is also adopted. However, there is no universally accepted medical image dataset specifically designed for pretraining models currently. The purpose of this study is to construct such a general dataset and validate its effectiveness on downstream medical imaging tasks, including classification and segmentation. In this work, we first build a medical image dataset by collecting several public medical image datasets (CPMID). And then, some pretrained models used for transfer learning are obtained based on CPMID. Various-complexity Resnet and the Vision Transformer network are used as the backbone architectures. In the tasks of classification and segmentation on three other datasets, we compared the experimental results of training from scratch, from the pretrained parameters on ImageNet, and from the pretrained parameters on CPMID. Accuracy, the area under the receiver operating characteristic curve, and class activation map are used as metrics for classification performance. Intersection over Union as the metric is for segmentation evaluation. Utilizing the pretrained parameters on the constructed dataset CPMID, we achieved the best classification accuracy, weighted accuracy, and ROC-AUC values on three validation datasets. Notably, the average classification accuracy outperformed ImageNet-based results by 4.30%, 8.86%, and 3.85% respectively. Furthermore, we achieved the optimal balanced outcome of performance and efficiency in both classification and segmentation tasks. The pretrained parameters on the proposed dataset CPMID are very effective for common tasks in medical image analysis such as classification and segmentation.
Prevalence of Paid Sex and Associated Factors Among Women and Men Attending HIV Voluntary Counseling and Testing in Kinshasa, Democratic Republic of the Congo: A Prospective Cohort
Authors: Carlos Silvia , Reina Gabriel , Burgueño Eduardo , Makonda Benit , de Irala Jokin , Beltramo Carlos , Díaz Herráez Paula , Burgo Cristina Lopez-del 
Published: August 2024

AbstractPaid sex is associated with HIV and other sexually transmitted infections, which are highly prevalent in Sub-Saharan Africa (SSA). However, few data exist on this sexual practice among the general population in SSA, including the Democratic Republic of the Congo, where data on paid sex mainly comes from sex workers. In the DRC, most HIV Voluntary Counseling and Testing (VCT) centers do not discuss paid sex as a risk factor. Thus, we aimed to analyze the prevalence of paid sex, its associated factors and association with HIV among women and men attending HIV VCT at a reference hospital in Kinshasa. From 2016 to 2018, the Observational Kinshasa AIDS Initiative cohort analyzed the impact of HIV VCT on changes in HIV knowledge, attitudes, and sexual behaviors at follow-up. Participants aged 15–69 years were HIV tested and interviewed at baseline and at 6- and 12-month follow-ups. At baseline, participants were asked about their history of “ever” having had exchanged sex for money. At both follow-ups, the frequency of this practice was referred to as “the previous 6 months.” Descriptive, bivariate, and multivariate logistic regression analyses were carried out to evaluate the prevalence of paid sex, its associated factors, and the association between paid sex and HIV. Statistical analyses were performed with Stata 15.1. Among 797 participants at baseline, 10% of those sexually experienced reported having ever had paid sex (18% men and 4% women, p < 0.001). At 6 and 12-month follow-ups, 5% and 2%, respectively. Paid sex was significantly and independently associated with being male (aOR = 2.7; 95% CI = 1.4–5.2), working or studying (aOR = 2.8; 95% CI = 1.5–5.0), daily newspaper reading (aOR = 4.4; 95% CI = 1.7–11.2); daily/weekly alcohol consumption (aOR = 3.3; 95% CI = 1.8–6.1), first sexual intercourse before age 15 years (aOR = 2.3; 95% CI = 1.1–5.0), multiple sexual partners (aOR = 4.1; 95% CI = 2.2–7.7), and extragenital sexual practices (aOR = 2.4; 95% CI = 1.3–4.4). A high religiosity (daily/weekly church attendance and praying) was inversely associated with paid sex (aOR = 0.1; 95% CI = 0.0–0.4). The high prevalence of paid sex among people attending HIV VCT in Kinshasa, associated with other sexual and consumption risk behaviors, highlights the need to include paid sex among the risk factors mentioned in HIV prevention counseling.
Media Reporting of Environmental Supply Chain Sustainability Risks: Contextual and Moderating Factors
Authors: Mateska Ivana , Wagner Stephan M. , Stienen Laura 
Published: August 2024

AbstractEthical and sustainable business practices in global supply chains have become a major concern for firms. Media stakeholders hold firms accountable for the environmentally unethical behavior of their suppliers. Based on agenda-setting theory and stakeholder theory, this study presents a model that shows how various internal and external factors explain media reporting of environmental supply chain sustainability risks. It also examines the role of firms’ risk avoidance practices. The study uses regression analysis of secondary data from 541 buying firms. The results show that the size and brand visibility of buying firms, and their affiliation to high-risk industries increase the frequency of media coverage of suppliers’ environmental misconduct, while their affiliation to high-risk countries decreases the frequency of media coverage. In addition, companies can reduce media coverage by implementing proactive supply chain sustainability risk avoidance practices. However, reactive supply chain sustainability risk avoidance practices are not effective in reducing media coverage.
Spatial and temporal ecology of Cerdocyon thous: a mesopredator canid coping with habitat loss, fragmentation, and chronic anthropogenic disturbances
Authors: Santos Tamara , Marinho Paulo Henrique , Venticinque Eduardo M. , Fonseca Carlos Roberto 
Published: August 2024

Abstract
Context
Human activities are reducing the amount and quality of natural landscapes. Understanding how such changes affect the spatial and temporal ecology of mammal populations will enable us to foresee how communities will be structured in the Anthropocene.

Objectives
Here, we evaluated how the occupancy, intensity of use, and activity patterns of the mesopredator canid Cerdocyon thous are affected by topographic variation, habitat amount, fragmentation and chronic anthropogenic disturbances.

Methods
Camera trapping data were obtained between May and September 2014 in 179 sampling points within ten priority areas for conservation in a seasonally dry tropical forest (Caatinga) in Brazil, totaling an effort of 6,701 camera.days. We use occupancy models for analyzed occupancy, generalized linear models (GLM) for the intensity of use and kernel density curve for activity pattern.

Results
Cerdoyon thous benefited from human disturbance, showing greater occupancy and intensity of use near anthropogenic habitats, fragmentation, human density and cattle density. Moreover, temporal analyses showed that it modulates its daily activity according to habitat amount, human density, cattle density and altitude. However, C. thous tends to avoid areas with excess of fire, logging and infrastructures.

Conclusions
These results allow us to understand the mechanisms that contribute to the dominance of generalist mesocarnivores in human-dominated environments.
Exploring the prognostic value of BRMS1 + microglia based on single-cell anoikis regulator patterns in the immunologic microenvironment of GBM
Authors: Zhao Songyun , Ni Kaixiang , Xie Jiaheng , Cheng Chao , Zhao Ning , Liu Jinhui , Ji Wei , Wang Qi , Zhang Pengpeng , Liu Yuankun 
Published: August 2024

Abstract
Background
Anoikis is a specialized form of programmed cell death induced by the loss of cell adhesion to the extracellular matrix (ECM). Acquisition of anoikis resistance is a significant marker for cancer cell invasion, metastasis, therapy resistance, and recurrence. Although current research has identified multiple factors that regulate anoikis resistance, the pathological mechanisms of anoikis-mediated tumor microenvironment (TME) in glioblastoma (GBM) remain largely unexplored.

Methods
Utilizing single-cell RNA sequencing (scRNA-seq) data and employing non-negative matrix factorization (NMF), we identified and characterized TME cell clusters with distinct anoikis-associated gene signatures. Prognostic and therapeutic response analyses were conducted using TCGA and CGGA datasets to assess the clinical significance of different TME cell clusters. The spatial relationship between BRMS1 + microglia and tumor cells was inferred from spatial transcriptome RNA sequencing (stRNA-seq) data. To simulate the tumor immune microenvironment, co-culture experiments were performed with microglia (HMC3) and GBM cells (U118/U251), and microglia were transfected with a BRMS1 overexpression lentivirus. Western blot or ELISA were used to detect BRMS1, M2 macrophage-specific markers, PI3K/AKT signaling proteins, and apoptosis-related proteins. The proliferation and apoptosis capabilities of tumor cells were evaluated using CCK-8, colony formation, and apoptosis assays, while the invasive and migratory abilities of tumor cells were assessed using Transwell assays.

Results
NMF-based analysis successfully identified CD8 + T cell and microglia cell clusters with distinct gene signature characteristics. Trajectory analysis, cell communication, and gene regulatory network analyses collectively indicated that anoikis-mediated TME cell clusters can influence tumor cell development through various mechanisms. Notably, BRMS1 + AP-Mic exhibited an M2 macrophage phenotype and had significant cell communication with malignant cells. Moreover, high expression of BRMS1 + AP-Mic in TCGA and CGGA datasets was associated with poorer survival outcomes, indicating its detrimental impact on immunotherapy. Upregulation of BRMS1 in microglia may lead to M2 macrophage polarization, activate the PI3K/AKT signaling pathway through SPP1/CD44-mediated cell interactions, inhibit tumor cell apoptosis, and promote tumor proliferation and invasion.

Conclusion
This pioneering study used NMF-based analysis to reveal the important predictive value of anoikis-regulated TME in GBM for prognosis and immunotherapeutic response. BRMS1 + microglial cells provide a new perspective for a deeper understanding of the immunosuppressive microenvironment of GBM and could serve as a potential therapeutic target in the future.
Board bias, information, and investment efficiency
Authors: Gregor Martin , Michaeli Beatrice 
Published: August 2024

AbstractWe identify a novel force behind the benefit of misaligned preferences in corporate governance. Our model entails a CEO who encounters a project and, after gathering information, decides whether to seek the approval of a corporate board. The CEO may be able to choose the properties of the collected information—this may happen if the project is “novel,” i.e., explores a new technology, business concept, or market and directors are less knowledgeable about it. We find that only sufficiently conservative and expansion-cautious directors can discipline the CEO’s empire-building tendency and opportunistic information collection. Such directors, however, underinvest in projects that are not novel. The board that maximizes firm value is either conservative or neutral (has interests aligned with the shareholders) and always overinvests in innovations. Boards with greater expertise are more likely to be conservative, but their bias is less severe. The board’s commitment power and bias are substitutes.