bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electric, magnetic and high frequency properties of screen printed ferrite-ferroelectric composite thick films on alumina substrate
Authors: Patil N. , Velhal N.B. , Pawar R. , Puri Vijaya 
Published: January 2015

Purpose
– The purpose of this article is to study the effect of ferrite content on electric, magnetic and microwave properties of screen-printed y(Ni0.4Co0.2Cd0.4Fe2O4) + (1 − y)Pb(Zr0.52Ti0.48)O3 (y = 0.0, 0.15, 0.30, 0.45, 1.0) thick films on alumina.

Design/methodology/approach
– Thick films of ferrite–ferroelectric composite on alumina substrate have been delineated using screen printing technique. The structural analysis was carried out using X-ray diffraction method and scanning electron microscopy. The DC electrical resistivity was measured using the two-probe method. The magnetic measurement was carried out using a vibrating sample magnetometer. Microwave absorption was studied in the 8-18 GHz frequency range by using the vector network analyzer (N5230A). The permittivity in the 8-18 GHz frequency range was measured by using voltage standing wave ratio slotted section method.

Findings
– The formation of two individual ferrite–ferroelectric phases in composite thick films was confirmed by the X-ray diffraction patterns. The scanning electron microscope morphologies show the growth of cobalt-substituted nickel cadmium ferrite grains which are well dispersed in lead zirconium titanate matrix. The DC electrical resistivity increases with increase in ferrite content and decreases with increase in temperature. The present ferrite shows ferromagnetic nature and it increases saturation magnetization and coercivity of the composite thick films. Tuning properties are observed in the Ku-band and broadband X-band microwave absorption is observed in the composite thick films. The imaginary part of permittivity increases with an increase in ferrite content, which increases microwave absorption. The real part of microwave permittivity varied from 17 to around 22 with an increase in ferrite content and it decreases with frequency. The microwave conductivity, which increases with an increase in ferrite content, reveals the loss of polaron conduction, which supports the dielectric loss in the microwave region.

Originality/value
– Electric, magnetic and microwave properties of screen-printed y(Ni0.4Co0.2Cd0.4Fe2O4) + (1 − y)Pb(Zr0.52Ti0.48)O3 (y = 0.0, 0.15, 0.30, 0.45, 1.0) composite thick films on alumina substrate is reported for the first time.
First insights into the giant panda (Ailuropoda melanoleuca) blood transcriptome: a resource for novel gene loci and immunogenetics
Authors: Du Lianming , Li Wujiao , Fan Zhenxin , Shen Fujun , Yang Mingyu , Wang Zili , Jian Zuoyi , Hou Rong , Yue Bisong , Zhang Xiuyue 
Published: January 2015

AbstractThe giant panda (Ailuropoda melanoleuca) is one of the most famous flagship species for conservation, and its draft genome has recently been assembled. However, the transcriptome is not yet available. In this study, the blood transcriptomes of three pandas were characterized and about 160 million sequencing reads were generated using Illumina HiSeq 2000 paired‐end sequencing technology. The assembly yielded 92 598 transcripts with an average length of 1626 bp and N50 length of 2842 bp. Based on a sequence similarity search against nonredundant (nr) protein database, a total of 38 522 (41.6%) transcripts were annotated. Of these annotated transcripts, 25 142 and 8272 transcripts were assigned to gene ontology terms and clusters of orthologous group, respectively. A search against the Kyoto Encyclopedia of Genes and Genomes Pathway database (KEGG) indicated that 9098 (9.83%) transcripts mapped to 324 KEGG pathways, and the best represented functional categories of pathways were signal transduction and immune system. We have also identified 23 460 microsatellites, 43 560 SNPs as well as 21 456 alternative splicing events in the assembly. Additionally, a total of 24 341 complete open reading frames (ORFs) were detected from the assembly where 1492 ORFs were found to be novel gene loci as these have not been annotated so far in any public database.
Cardiac sympathetic afferent reflex and its implications for sympathetic activation in chronic heart failure and hypertension
Authors: Chen W.‐W. , Xiong X.‐Q. , Chen Q. , Li Y.‐H. , Kang Y.‐M. , Zhu G.‐Q. 
Published: January 2015

AbstractPersistent excessive sympathetic activation greatly contributes to the pathogenesis of chronic heart failure (CHF) and hypertension. Cardiac sympathetic afferent reflex (CSAR) is a sympathoexcitatory reflex with positive feedback characteristics. Humoral factors such as bradykinin, adenosine and reactive oxygen species produced in myocardium due to myocardial ischaemia stimulate cardiac sympathetic afferents and thereby reflexly increase sympathetic activity and blood pressure. The CSAR is enhanced in myocardial ischaemia, CHF and hypertension. The enhanced CSAR at least partially contributes to the sympathetic activation and pathogenesis of these diseases. Nucleus of the solitary tract (NTS), hypothalamic paraventricular nucleus (PVN) and rostral ventrolateral medulla are the most important central sites involved in the modulation and integration of the CSAR. Angiotensin II, AT1 receptors and NAD(P)H oxidase‐derived superoxide anions pathway in the PVN are mainly responsible for the enhanced CSAR in CHF and hypertension. Central angiotensin‐(1‐7), nitric oxide, endothelin, intermedin, hydrogen peroxide and several other signal molecules are involved in regulating CSAR. Blockade of the CSAR shows beneficial effects in CHF and hypertension. This review focuses on the anatomical and physiological basis of the CSAR, the interaction of CSAR with baroreflex and chemoreflex, and the role of enhanced CSAR in the pathogenesis of CHF and hypertension.
Inhibition of DMBA‐induced Oral Squamous Cells Carcinoma Growth by Brazilian Red Propolis in Rodent Model
Authors: Ribeiro Danielle R. , Alves Ângela Valéria F. , dos Santos Esaú P. , Padilha Francine F. , Gomes Margarete Z. , Rabelo Alessandra S. , Cardoso Juliana C. , Massarioli Adna Prado , de Alencar Severino Matias , de Albuquerque‐Júnior Ricardo Luiz C. 
Published: January 2015

AbstractWe investigated the effect of oral administration of hydroalcoholic extract of Brazilian red propolis (HERP) on DMBA‐induced oral squamous cell carcinomas (OSCC) in rodents. The chemical components of the HERP were assessed by high‐performance liquid chromatography (HPLC). Carcinogenesis was topically induced in the lower lip of 25 rats using 9,10‐dimethyl‐1,2‐benzanthracene (DMBA); the tumour was treated with saline (TUM1) and Tween 80 (TUM2) as well as HERP at 10, 50 and 100 mg/kg (HERP10, HERP50 and HERP100, respectively) for 20 weeks. Topical application of saline and oral administration of 100 mg/kg HERP was used in five rats as a control group (CTR). After 26 weeks, the histological malignancy grading and immunohistochemical expression of Ki‐67 and p16INK4A were assessed in the tumours/tissue samples. The compounds identified were propyl gallate, daidzein, catechin, epicatechin, formononetin and biochanin A. Formononetin, daidzein and biochanin A showed concentration of 23.29, 0.38 and 0.67 mg/g of HERP, respectively. HERP at doses of 50 and 100 mg/kg inhibited 40% of OSCC growth and promoted a 3‐week delay in development of clinically detectable tumours. Epithelial dysplasia was observed in all samples with no clinical tumour, except in CTR. No significant difference in the immunoexpression of Ki‐67 and p16INK4A was observed between HERP‐treated and saline/Tween 80‐treated groups (p > 0.05). Our results suggest that HERP exerts chemopreventive activity on the progression of DMBA‐induced epithelial dysplasia to OSCC in an experimental model of labial carcinogenesis; however, this effect is not associated with Ki‐67 and p16INK4A immunoexpression.
Statin‐induced Myopathy and Ubiquinone Levels in Serum – Results from a Prospective, Observational Study
Authors: Skilving Ilona , Acimovic Jure , Rane Anders , Ovesjö Marie‐Louise , Björkhem‐Bergman Linda 
Published: January 2015

AbstractIt has been suggested that an impaired ubiquinone (Q10) synthesis may be responsible for muscular side effects caused by statins. The primary aim of this study was to investigate whether low Q10 levels in serum could be used as a marker to predict the risk of developing statin‐induced myopathy. The secondary aim was to compare the change in Q10 levels during statin treatment and differences between men and women. Serum samples from a prospective, observational study in statin‐treated patients who were thoroughly followed regarding muscular symptoms were used. In this cohort, 16 developed myopathy and 126 had no muscular symptoms related to statin treatment. Q10 levels were measured with a novel LC‐MS method at baseline and after 2 months of statin treatment. Q10 levels showed no correlation with the risk of developing statin‐induced myopathy. Individuals with low levels, Q10 < 200 ng/ml, at baseline had no increased risk of developing myopathy. In consistence with earlier reports, we showed that Q10 levels were reduced by 30% during statin treatment. There was no significant difference in the reduction between patients with or without myopathy. Women had approximately 30% lower Q10 levels compared to men both before and after treatment. In this study, there was no association between Q10 levels at baseline and statin‐induced muscular side effects during a 2‐month follow‐up period, and our results indicate that Q10 levels in serum is not a useful marker to predict statin‐induced myopathy.
Peer support for parents of disabled children part 2: how organizational and process factors influenced shared experience in a one‐to‐one service, a qualitative study
Authors: Shilling V. , Bailey S. , Logan S. , Morris C. 
Published: January 2015

AbstractBackgroundParents of disabled children often seek support from their peers. The shared experience between parents appears to be a crucial mediating factor. Understanding how a sense of shared experience is fostered can help to design and evaluate services that seek to provide peer support.MethodsWe carried out a qualitative study involving semi‐structured interviews and focus groups. Participants were 12 parents and 23 befrienders who had contact with the Face2Face one‐to‐one befriending service in Devon and Cornwall during a 12‐month period, and 10 professionals from health, social care and education.FindingsFormal structures and processes in place such as training and ongoing supervision and support were highly valued as was the highly personalized, confidential, flexible, one‐to‐one at‐home nature of the service. Crucial to establishing rapport was putting the right people together and ensuring a good match between befrienders and parents. Clearly, the befriending parent has to be emotionally prepared to provide help. However, if the parent being offered support was not ready to accept help at the time it was offered or the type of support was not right for them, they are less likely to engage with the service.ConclusionOrganizational and process factors as well as characteristics of the parents offering and receiving support contribute to the sense of shared experience in one‐to‐one peer support. These factors interact to influence whether peer support is effective and should be explicitly considered when designing and evaluating services.
Metastatic phaeochromocytoma in a 23‐year‐old woman with an unclassified variant in the von Hippel Lindau disease gene: how can the pathogenicity of this variant be determined?
Authors: Russell Nicholas , Delatycki Martin , Grossmann Mathis 
Published: January 2015

SummaryA 23‐year‐old woman with metastatic phaeochromocytoma was found to have a previously unclassified variant in the von Hippel Lindau disease gene (c.361G>C). We use this case to highlight the issue of unclassified single nucleotide variants and the approaches to help predict whether they are disease causing or neutral. With increasing use of genetic testing, and widespread clinical use of next‐generation sequencing around the corner, this issue is likely to become more prominent.
Fasting but not changes of plasma metabolome during oral glucose tolerance tests improves the diagnosis of severe coronary arterial stenosis
Authors: Hung Chi‐Sheng , Li Hung‐Yuan , Kuo Ching‐Hua , Lin Mao‐Shin , Kuo Tien‐Chueh , Tsai Sung‐Jeng , Liu Pi‐Hua , Lin Cheng‐Hsin , Yang Chun‐Yi , Chuang Lee‐Ming , Chen Ming‐Fong , Tseng Yufeng J. , Kao Hsien‐Li 
Published: January 2015

SummaryBackgroundNoninvasive stress tests for the diagnosis of significant coronary arterial stenosis requiring intervention are not perfect. We investigated whether plasma metabolome during the oral glucose tolerance test (OGTT) can improve the diagnosis.MethodsA total of 117 subjects with positive stress test results who received coronary angiography were recruited. After excluding subjects with a history of myocardial infarction and subjects who did not receive OGTT, the 18 subjects without significant stenosis were selected as controls. Another 18 age‐ and sex‐matched subjects with significant stenosis were selected as cases. Plasma metabolome from samples obtained in fasting, 30 and 120 min after OGTT was measured using liquid chromatography combined with time‐of‐flight mass spectrometry.ResultsWe found five metabolites which can identify patients with significant stenosis independent to clinical risk factors, including diabetes, hypertension, hypercholesterolaemia, smoking and history of percutaneous coronary intervention (all P < 0·05). The area under the receiver operating characteristic (AUROC) curve of these metabolites was 0·799–0·818 at fasting and 30 min after OGTT. The addition of metabolites to clinical factors increases the AUROC (0·616, 95%CI 0·429–0·803 for model with clinical factors only; 0·824, 95%CI 0·689–0·959 for model with four metabolites and clinical factors). The changes of plasma metabolite levels during OGTT did not significantly improve the diagnostic performance.ConclusionsFasting plasma metabolome, but not change of plasma metabolome during OGTT, can improve the diagnosis of significant stenosis in patients with positive noninvasive stress test results.
Cell‐to‐cell communication – periodontal regeneration
Authors: Bosshardt Dieter D. , Stadlinger Bernd , Terheyden Hendrik 
Published: January 2015

AbstractBackgroundAlthough regenerative treatment options are available, periodontal regeneration is still regarded as insufficient and unpredictable.AimThis review article provides scientific background information on the animated 3D film Cell‐to‐Cell Communication – Periodontal Regeneration.ResultsPeriodontal regeneration is understood as a recapitulation of embryonic mechanisms. Therefore, a thorough understanding of cellular and molecular mechanisms regulating normal tooth root development is imperative to improve existing and develop new periodontal regenerative therapies. However, compared to tooth crown and earlier stages of tooth development, much less is known about the development of the tooth root. The formation of root cementum is considered the critical element in periodontal regeneration. Therefore, much research in recent years has focused on the origin and differentiation of cementoblasts. Evidence is accumulating that the Hertwig's epithelial root sheath (HERS) has a pivotal role in root formation and cementogenesis. Traditionally, ectomesenchymal cells in the dental follicle were thought to differentiate into cementoblasts. According to an alternative theory, however, cementoblasts originate from the HERS. What happens when the periodontal attachment system is traumatically compromised? Minor mechanical insults to the periodontium may spontaneously heal, and the tissues can structurally and functionally be restored. But what happens to the periodontium in case of periodontitis, an infectious disease, after periodontal treatment? A non‐regenerative treatment of periodontitis normally results in periodontal repair (i.e., the formation of a long junctional epithelium) rather than regeneration. Thus, a regenerative treatment is indicated to restore the original architecture and function of the periodontium. Guided tissue regeneration or enamel matrix proteins are such regenerative therapies, but further improvement is required. As remnants of HERS persist as epithelial cell rests of Malassez in the periodontal ligament, these epithelial cells are regarded as a stem cell niche that can give rise to new cementoblasts. Enamel matrix proteins and members of the transforming growth factor beta (TGF‐ß) superfamily have been implicated in cementoblast differentiation.ConclusionA better knowledge of cell‐to‐cell communication leading to cementoblast differentiation may be used to develop improved regenerative therapies to reconstitute periodontal tissues that were lost due to periodontitis.
Diffuse and strong cyclin D1 immunoreactivity in clear cell sarcoma of the kidney
Authors: Mirkovic Jelena , Calicchio Monica , Fletcher Christopher D , Perez‐Atayde Antonio R 
Published: January 2015

AimsDistinguishing clear cell sarcoma of the kidney (CCSK) from other paediatric malignancies, particularly blastema‐rich Wilms tumour (WT) and congenital mesoblastic nephroma (CMN), is challenging. Specific immunohistochemistry for CCSK does not exist, and diagnosis rests upon histopa thology. Recently, the YWHAE–FAM22 rearrange ment, identical to that in endometrial stromal sarcoma (ESS), has been identified in CCSKs. As this fusion results in overexpression of cyclin D1 in ESS, we postulated that overexpression would also occur in CCSK; cyclin D1 immunohistochemistry could then be used to differentiate CCSK from other tumours. The goal of this study was therefore to evaluate the utility of cyclin D1 immunohistochemistry in identifying CCSK and helping to differentiate it from its mimics.Methods and resultsCyclin D1 expression was evaluated in 59 renal tumours—CCSK (14), WT (25), rhabdoid tumour (four), Ewing sarcoma (five), and CMN (11)—and four neuroblastomas. All 14 CCSKs showed diffuse and strong reactivity. In contrast, the blastematous component of most WTs showed only rare positive nuclei, that of rhabdoid tumours showed rare to focal immunoreactivity, and that of more than half of CMNs showed weak or focal immunoreactivity. Most Ewing sarcomas and all neuroblastomas showed diffuse moderate to strong staining.ConclusionsCyclin D1 is most helpful in distinguishing CCSK from WT, rhabdoid tumour, and some CMNs, but not from neuroblastoma or Ewing sarcomas.
High‐Energy Storage Performance of (Pb0.87Ba0.1La0.02)(Zr0.68Sn0.24Ti0.08)O3 Antiferroelectric Ceramics Fabricated by the Hot‐Press Sintering Method
Authors: Zhang Guangzu , Zhu Dingyang , Zhang Xiaoshan , Zhang Ling , Yi Jinqiao , Xie Bing , Zeng Yike , Li Qi , Wang Qing , Jiang Shenglin 
Published: January 2015

(Pb0.87Ba0.1La0.02)(Zr0.68Sn0.24Ti0.08)O3 (PBLZST) antiferroelectric (AFE) ceramics have been prepared by hot‐press sintering method and conventional solid‐state reaction process, and the dependence of microstructure and energy storage properties of the ceramics on sintering approaches has been studied. The results reveal that not only the microstructure, but also the electrical properties of the PBLZST AFE ceramics are significantly improved by using the hot‐press sintering method. Samples resulting from the hot‐press sintering process have high breakdown strength of 180 kV/cm which results from the increase of density. Coupled with large polarization, the hot‐pressed AFE ceramics are shown to have a high recoverable energy density of 3.2 J/cm3. The recoverable energy density of the hot‐pressed PBLZST AFE ceramics is 100% greater than the conventional sintered specimens with recoverable energy density of 1.6 J/cm3.
Does behaviour play a role in house fly resistance to imidacloprid‐containing baits?
Authors: SERAYDAR K. R. , KAUFMAN P. E. 
Published: January 2015

AbstractThe objective of this research was to examine the role and type of behavioural mechanisms that function in house fly, Musca domestica L. (Diptera: Muscidae), resistance to an imidacloprid‐containing commercial fly bait, QuickBayt®, using an insecticide‐susceptible and an imidacloprid‐resistant strain. Mortality and feeding behaviour were observed through choice bioassays of three post‐imidacloprid selected house fly generations to determine whether flies would consume the bait in the presence of an alternative food source. Mortality rates in choice containers progressively decreased in post‐selection flies as QuickBayt® no‐choice selections proceeded. There were no differences between the proportions of flies observed contacting QuickBayt® and sugar, respectively, a finding that eliminates repellency as a mechanism of stimulus‐dependent behavioural resistance. However, differences in QuickBayt® consumption and subsequent mortality between choice and no‐choice containers provided strong support for the evolution of consumption irritancy‐ or taste aversion‐related behavioural resistance. The results of this study support the responsible rotation of insecticide bait formulations for house fly control.
Behavioural responses of stable flies to cattle manure slurry associated odourants
Authors: TANGTRAKULWANICH K. , ALBUQUERQUE T. A. , BREWER G. J. , BAXENDALE F. P. , ZUREK L. , MILLER D. N. , TAYLOR D. B. , FRIESEN K. A. , ZHU J. J. 
Published: January 2015

AbstractStable flies (Stomoxys calcitrans [Diptera: Muscidae] L.) are blood‐feeding synanthropic pests, which cause significant economic losses in livestock. Stable fly antennae contain olfactory sensilla responsive to host and host environment‐associated odours. Field observation indicated that the abundance of stable flies increased significantly in grasslands or crop fields when cattle manure slurry was applied. Major volatile compounds emanating from manure slurry were collected and identified. Behavioural responses of stable flies to those compounds were investigated in laboratory bioassays and field‐trapping studies. Results from olfactometer assays revealed that phenol, p‐cresol and m‐cresol were attractive to adult stable flies. When tested individually, attraction was higher with lower dosages. Stable flies were most attracted to blends of phenol and m‐cresol or p‐cresol. Traps with binary blend lures caught more stable flies in field trials as well.