bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of D-dimer levels for the detection of deep venous thrombosis for patients with spinal metastasis undergoing decompression with fixation
Authors: Jiang Yun-qi , Wang Yu-zhu , Hu An-nan , Zhou Jian , Li Xi-lei , Qi Qing , Dong Jian 
Published: August 2024

Abstract
Background
Deep venous thrombosis (DVT) after spinal surgery has recently attracted increasing attention. Patients with spinal metastases who undergo decompression with fixation are at a high risk of developing DVT. D-dimer levels indicate the risk of DVT, and the purpose of our study was to investigate D-dimer levels as a predictor of DVT perioperatively.

Methods
We prospectively evaluated 100 patients with spinal metastases. D-dimer tests were performed twice: once before surgery and one day postoperatively. DVT was diagnosed by duplex ultrasonographic assessment of both lower extremities. Pulmonary embolisms (PEs) were diagnosed using multidetector computed tomography and pulmonary angiography. Perioperative serum D-dimer levels were compared between the DVT (+) and DVT (-) groups. The cutoff value of the D-dimer level was calculated using receiver operating characteristic analysis.

Results
Preoperative and postoperative DVT prevalences were 8.0% (8/100) and 6.6% (6/91), respectively, and none of the patients developed PE. Before surgery, there was no significant differences in D-dimer levels between the pre-DVT (+) and pre-DVT (-) groups. After surgery, the D-dimer level one-day postoperatively for the post-DVT (+) group (17.6 ± 11.8 mg/L) was significantly higher than that of the post-DVT (-) group (5.0 ± 4.7 mg/L). The cutoff value of the postoperative D-dimer level was 9.51(mg/L), and the sensitivity and specificity for the optimum threshold were 83.3% and 89.4%, respectively.

Conclusions
Our findings suggest that preoperative D-dimer level may not be a predictor of DVT. Preoperative ultrasound examinations should be routinely performed in patients with spinal metastases. Postoperative D-dimer levels greater than 9.51(mg/L) are a predictive factor for the early diagnosis of DVT after spine surgery.

Trial registration
Our study was registered on Chinese Clinical Trial Registry (No.ChiCTR2000029737). Registered 11 February 2020 - Retrospectively registered, https://www.chictr.org.cn/index.aspx.
Effect evaluation of outpatient long-term video EEGs for people with seizure disorders – study protocol of the ALVEEG project: a randomized controlled trial in Germany
Authors: Münchenberg Pauline Sarah , Schulz Ricarda Sophia , Wainwright Kerstin , Mayer Imke , Holtkamp Martin , Meisel Christian , Kurth Tobias ,   the ALVEEG Consortium, Vorderwülbecke Bernd , Steinbrenner Mirja , Endres Matthias , Gorski Claudia , Prasser Fabian , Kaindl Angela , Weschke Bernhard , Potratz Cornelia , Fenske Pascal , von Podewils Felix , Bertsche Astrid , Viebahn Sarah Mai , Gaida Bernadette , Utzig Norbert , Schulz Juliane , Mayer Thomas , Hopp Peter , Holert Nils , Wienecke Miriam , Leonhardt Georg , Müller Peggy , Knobelsdorf Petra , Wolter Antke , Klinker Anne , Brandebusemeyer Mara , Nussbaum Uwe , Seemann Jannis 
Published: August 2024

Abstract
Background
Epilepsy and other seizure disorders account for a high disease burden in Germany. As a timely diagnosis and accurate treatment are crucial, improving the management of these disorders is important. Outside of Germany, outpatient long-term video EEGs (ALVEEGs) have demonstrated the potential to support the diagnosis and management of epilepsy and other seizure disorders. This study aims to evaluate the implementation of ALVEEGs as a new diagnostic pathway in eastern parts of Germany to diagnose epilepsy and other seizure disorders and to assess if ALVEEGs are equally effective as the current inpatient-monitoring gold standard, which is currently only available at a limited number of specialized centers in Germany.

Methods
ALVEEG is a prospective, multicenter, randomized controlled equivalence trial, involving five epilepsy centers in the eastern states of Germany. Patients will be randomized into either intervention (IG) or control group (CG), using a permuted block randomization. The sample size targeted is 688 patients, continuously recruited over the trial. The IG will complete an ALVEEG in a home setting, including getting access to a smartphone app to document seizure activity. The CG will receive care as usual, i.e., inpatient long-term video-EEG monitoring. The primary outcome is the proportion of clinical questions being solved in the IG compared to the CG. Secondary outcomes include hospital stays, time until video EEG, time until diagnosis and result discussion, patients’ health status, quality of life and health competence, and number and form of epilepsy-related events and epileptiform activity. Alongside the trial, a process implementation and health economic evaluation will be conducted.

Discussion
The extensive evaluation of this study, including an implementation and health economic evaluation, will provide valuable information for health policy decision-makers to optimize future delivery of neurological care to patients affected by epilepsy and other seizure disorders and on the uptake of ALVEEG into standard care in Germany.

Trial registration
German Clinical Trials Register (DRKS00032220), date registered: December 11, 2023.
Continuity of medication information transfer and continuous medication supply during hospital-to-home transitions - nationwide surveys in hospital and community pharmacies after implementing new legal requirements in Germany
Authors: Klasing Sophia , Dörje Frank , Hilgarth Heike , Metzger Nadine , Richling Ina , Seidling Hanna M. 
Published: August 2024

Abstract
Background
While successful information transfer and seamless medication supply are fundamental to medication safety during hospital-to-home transitions, disruptions are frequently reported. In Germany, new legal requirements came into force in 2017, strengthening medication lists and discharge summaries as preferred means of information transfer. In addition to previous regulations – such as dispensing medication at discharge by hospital pharmacies – hospital physicians were now allowed to issue discharge prescriptions to be supplied by community pharmacies. The aim of this survey study was to gain first nationwide insights into how these requirements are implemented and how they impact the continuity of medication information transfer and continuous medication supply.

Methods
Two nationwide self-administered online surveys of all hospital and community pharmacies across Germany were developed and conducted from April 17th to June 30th, 2023.

Results
Overall, 31.0% (n = 111) of all German hospital pharmacies and 4.5% (n = 811) of all community pharmacies participated. The majority of those hospital pharmacies reported that patients who were discharged were typically provided with discharge summaries (89.2%), medication lists (59.5%) and if needed, discharge prescriptions (67.6%) and/or required medication (67.6%). About every second community pharmacy (49.0%) indicated that up to half of the recently discharged patients who came to their pharmacy typically presented medication lists. 34.0% of the community pharmacies stated that they typically received a discharge summary from recently discharged patients at least once per week. About three in four community pharmacies (73.3%) indicated that most discharge prescriptions were dispensed in time. However, one-third (31.0%) estimated that half and more of the patients experienced gaps in medication supply. Community pharmacies reported challenges with the legal requirements – such as patients´ poor comprehensibility of medication lists, medication discrepancies, unmet formal requirements of discharge prescriptions, and poor accessibility of hospital staff in case of queries. In comparison, hospital pharmacies named technical issues, time/personnel resources, and deficits in patient knowledge of medication as difficulties.

Conclusion
According to the pharmacies´ perceptions, it can be assumed that discontinuation in medication information transfer and lack of medication supply still occur today during hospital-to-home transitions, despite the new legal requirements. Further research is necessary to supplement these results by the perspectives of other healthcare professionals and patients in order to identify efficient strategies.
Retrospective ANalysis of multi-drug resistant Gram-nEgative bacteRia on veno-venous extracorporeal membrane oxygenation. The multicenter RANGER STUDY
Authors: Boscolo Annalisa , Bruni Andrea , Giani Marco , Garofalo Eugenio , Sella Nicolò , Pettenuzzo Tommaso , Bombino Michela , Palcani Matteo , Rezoagli Emanuele , Pozzi Matteo , Falcioni Elena , Pistollato Elisa , Biamonte Eugenio , Murgolo Francesco , D’Arrigo Graziella , Gori Mercedes , Tripepi Giovanni Luigi , Gottin Leonardo , Longhini Federico , Grasso Salvatore , Navalesi Paolo , Foti Giuseppe 
Published: August 2024

Abstract

Background
Veno-venous extracorporeal membrane oxygenation (V-V ECMO) is a rapidly expanding life-support technique worldwide. The most common indications are severe hypoxemia and/or hypercapnia, unresponsive to conventional treatments, primarily in cases of acute respiratory distress syndrome. Concerning potential contraindications, there is no mention of microbiological history, especially related to multi-drug resistant (MDR) bacteria isolated before V-V ECMO placement. Our study aims to investigate: (i) the prevalence and incidence of MDR Gram-negative (GN) bacteria in a cohort of V-V ECMOs; (ii) the risk of 1-year mortality, especially in the case of predetected MDR GN bacteria; and (iii) the impact of annual hospital V-V ECMO volume on the probability of acquiring MDR GN bacteria.

Methods
All consecutive adults admitted to the Intensive Care Units of 5 Italian university-affiliated hospitals and requiring V-V ECMO were screened. Exclusion criteria were age < 18 years, pregnancy, veno-arterial or mixed ECMO-configuration, incomplete records, survival < 24 h after V-V ECMO. A standard protocol of microbiological surveillance was applied and MDR profiles were identified using in vitro susceptibility tests. Cox-proportional hazards models were applied for investigating mortality.

Results
Two hundred and seventy-nine V-V ECMO patients (72% male) were enrolled. The overall MDR GN bacteria percentage was 50%: 21% (n.59) detected before and 29% (n.80) after V-V ECMO placement. The overall 1-year mortality was 42%, with a higher risk observed in predetected patients (aHR 2.14 [1.33–3.47], p value 0.002), while not in ‘V-V ECMO-acquired MDR GN bacteria’ group (aHR 1.51 [0.94–2.42], p value 0.090), as compared to ‘non-MDR GN bacteria’ group (reference). Same findings were found considering only infections. A larger annual hospital V-V ECMO volume was associated with a lower probability of acquiring MDR GN bacteria during V-V ECMO course (aOR 0.91 [0.86–0.97], p value 0.002).

Conclusions
21% of MDR GN bacteria were detected before; while 29% after V-V ECMO connection. A history of MDR GN bacteria, isolated before V-V ECMO, was an independent risk factor for mortality. The annual hospital V-V ECMO volume affected the probability of acquiring MDR GN bacteria.

Trial Registration ClinicalTrial.gov Registration Number NCTNCT06199141, date 12.26.2023.
Role of physical structure on performance index of crossflow microchannel heat exchanger with regression analysis
Authors: Jahan Salma , Nasrin Rehena 
Published: August 2024

AbstractMicrochannel heat exchangers have become the preferred choice in contemporary technologies like electronics, refrigeration, and thermal management systems. Their popularity stems from their compact design and exceptional efficiency, which outperform traditional heat exchangers (HE). Despite ongoing efforts, the optimal microchannels for enhancing heat management, minimizing pressure drop, and boosting overall performance have yet to be identified. This study seeks to deepen our understanding of heat transmission and fluid dynamics within a cross-flow microchannel heat exchanger (CFMCHE). Utilizing numerical modeling, it examines how various physical aspects—such as channel geometry, spacing between channels, the number of channels, and the velocity at the inlet—affect key performance indicators like pressure drop, effectiveness, Nusselt number, and overall efficiency. To enhance the design, we analyze six unique shapes of crossflow microchannel heat exchangers: circular, hexagonal, trapezoidal, square, triangular, and rectangular. We employ the Galerkin-developed weighted residual finite element method to numerically address the governing three-dimensional conjugate partial differential coupled equations. The numerical results for each shape are presented, focusing on the surface temperature, pressure drop, and temperature contours. Additionally, calculations include the efficacy, the heat transfer rate in relation to pumping power, and the overall performance index. The findings reveal that while circular shapes achieve the highest heat transfer rates, they underperform compared to square-shaped CFMCHEs. This underperformance is largely due to the increased pressure drop in circular channels, which also exhibit a 1.03% greater reduction in effectiveness rate than their square-shaped counterparts. Consequently, square-shaped channels, boasting a performance index growth rate of 53.57%, emerge as the most effective design among the six shapes evaluated. Additionally, for the square-shaped CFMCHE, we include residual error plots and present a multiple-variable linear regression equation that boasts a correlation coefficient of 0.8026.
The crustal deformation mechanism of southern Chuandian block: constrained by S wave velocity and its azimuthal anisotropy
Authors: Gao Zaiji , Sun Ya , Huang Jiwen , Li Qiu 
Published: August 2024

AbstractWe construct the 3D Shear wave velocity and azimuthal anisotropy images in the southern Chuandian block using phase velocity dispersion of Rayleigh wave in the period of 5–45 s. The images show two extensive low-velocity zones with a depth range of 20–40 km. The west range of the low-velocity extends from the Lijiang-Xiaojinhe fault to the Red River fault, while its east range follows along the Xiaojiang fault. Two ranges of low velocities are merged at the southern inner belt of the Emeishan Large Igneous Provinces (ELIP). The observed fast directions of azimuthal anisotropy are consistent with the extension of low-velocity ranges at the lower crust. The findings reveal the presence of two potential weak channels in the lower crust, characterized by low-velocity zones, which align with the hypothesis of lower crustal flow. Meanwhile, the crust around the inner belt of ELIP exhibits a high-velocity body characterized by a northeast-trending and counter-clockwise azimuthal anisotropy. Combined with geological data, we attribute the high S-velocity to a mafic–ultramafic magma reservoir of the ELIP, which blocks the continuity of crustal flow within the southern Chuandian block, thus dividing the lower crustal flow into two branches. Additionally, we also find the fast directions of azimuthal anisotropy above 20 km align well with the strike-slip fault orientations. The above research results indicate that the crustal deformation in the southern Chuandian block is likely attributed to the joint action of the two deformation mechanisms. One involves a lower crustal flow model, while the other entails rigid extrusion controlled by the deep-seated, large-scale strike-slip faults in the upper crust.
Exploring the potential of chestnut (Castanea sativa Mill.): a comprehensive review and conceptual mapping
Authors: Abdelwahab Siddig Ibrahim , Taha Manal Mohamed Elhassan , Aljahdali Ieman , Oraibi Bassem , Alzahrani Amal , Farasani Abdullah , Alfaifi Hassan , Babiker Yasir 
Published: August 2024

Abstract
Background
Castanea sativa Mill. is important for ecosystems and societies. Its rich historical and cultural significance, remarkable ecological contributions, and diverse applications have inspired scientific research. This comprehensive review and conceptual mapping of chestnut research consolidates existing knowledge, identifies emerging trends, and highlights untapped potential to inform future investigations. First, the Scopus database was searched to retrieve all data-driven articles in English related to C. sativa published in English from 1951 to 2023. Second, the R language, Scopus Analytics, and VOSviewer were used to analyze the year of publication, authors, countries, affiliations, keywords, and citations. Finally, network analysis was performed to evaluate the hotspots and developmental trends of C. sativa. A total of 1889 research articles were recovered.

Results
The articles showed an exponential progression, with a regression coefficient of 0.9435 (R2) and an annual growth rate of 6.28%. Italy (19.87%), Spain (15.56%), Portugal (13.39%), Turkey (6.92%), and Switzerland (5.17%) were the most prolific countries. C. sativa (798), sweet chestnut (54), cryphonectria parasitica (44), honey (38), phenolic compounds (35), chestnut blight (33) and antioxidant activity (31) are the keywords that occur the most frequently. The main research groups in the thematic map are "forest management," "Cryphonectria parasitica," "wood," "Spain" and "ethnobotany." Research on C. sativa has all the basic, motor, niche, and emerging or declining themes. Forest management, drought, Gnomoniopsis smithogilvyi, C. sativa shells, amino acids, honey, phenolic compounds, hydrolyzable tannins, antioxidant capacity, antioxidants, and extractives are trending topics.

Conclusions
This bibliometric analysis highlights the importance of C. sativa research, revealing its ecological contributions, cultural significance, and diverse applications. Future studies should focus on forest management, drought resistance, and bioactive properties to ensure sustainable utilization.
Barriers and opportunities for implementing prescribed fire: lessons from managers in the mid-Atlantic region, United States
Authors: Smithwick Erica A. H. , Wu Hong , Spangler Kaitlyn , Adib Mahsa , Wang Rui , Dems Cody , Taylor Alan , Kaye Margot , Zipp Katherine , Newman Peter , Miller Zachary D. , Zhao Anthony 
Published: August 2024

Abstract
Background
Prescribed burning is a beneficial fire management practice used by practitioners worldwide to meet multiple land management objectives, including reduction of wildfire hazard, promotion of biodiversity, and management of vegetation for wildlife and human interests. Meeting these objectives can be difficult due to the need for institutional coordination, resource and policy constraints, and community support. We examined these dynamics in the United States’ mid-Atlantic region because prescribed fire use is increasing in the region to meet a broadening set of land management objectives. Managers are at the frontlines of these challenges and hold significant experience and knowledge for enhancing wildland fire management policy and strategy. Towards better leveraging this insight, we conducted focus groups with fire managers in land management agencies in the region to identify managers’ perceived barriers and opportunities for implementing prescribed fire.

Results
We found manager perceptions to be hierarchical, with barriers and opportunities expressed across landscape, community, and individual levels. Limited institutional coordination across landscapes was seen by managers as an opportunity for expanding prescribed fire implementation, whereas coping with shared fear or stress about burning among individual managers or individual community members was seen as a significant barrier. Yet, despite different prescribed burning histories and policies at the state level, barriers and opportunities were similar among managers in the mid-Atlantic region.

Conclusions
Managers in the mid-Atlantic region confront barriers to prescribed fire use but are also uniquely positioned to recognize opportunities to enhance its implementation. This work sheds light on these barriers and opportunities, revealing that managers desire greater opportunities for landscape-level fire planning and coordination across agencies as well as greater opportunities for community engagement and interpersonal trust-building within complex social-management networks. Manager perspectives from the mid-Atlantic provide lessons for other regions across the globe grappling with new or broadened land-management strategies that include beneficial fire use.
Suicidal behaviors in mental illness: A case-control study. Suicidal behaviors in mental illness: A case-control study
Authors: Boumnijel A. , Rouached S. , Boudriga S. , Lagha M. , Homri W. , Ben Rhomdhane I. , Labbane R. 
Published: August 2024

IntroductionThe assessment of suicide risk remains a critical concern, especially within the psychiatric community. Mental health professionals continually work to identify and support individuals at risk, emphasizing the need for ongoing research and training in this area.ObjectivesThe objectives of our study were to understand the characteristics of patients hospitalized after a suicide attempt (SA), analyze the characteristics of these attempts, identify risk factors associated with suicidal behaviors, and determine predictors for recurring suicidal behavior.MethodsThe study’s methodology was retrospective, descriptive, and comparative. It was conducted with 277 patients hospitalized in the psychiatric department “C” of Razi Psychiatric Hospital in Manouba. The sample consists of 72 individuals who attempted suicide, divided into two groups: first-time attempters and recurrent patients, and 205 controls hospitalized for other reasons during the same period.ResultsResults showed a significant increase in the frequency of hospitalizations for SA, rising from 0.7% to 2.25% of the total admissions between 2018 and 2022. Those who attempted suicide were on average 32.5 years old, predominantly female, urban residents, with a moderate socioeconomic status, secondary or higher education, unemployed, unmarried, childless, and lacking strong family support.The study identified several risk factors associated with suicide attempts, including risky behaviors, previous life events, type II bipolar disorders, personality disorders, the number of psychiatric hospitalizations, and the quality of follow-up. However, schizophrenia was negatively correlated with SA.Suicidal recurrence was observed in 65.5% of attempters and was linked to personal psychiatric follow-up history, mood disorders, personality disorders, the presence of stress factors, and caustic substance ingestion.ConclusionsIn conclusion, the study underscores the importance of assessing suicide risk among individuals with mental disorders to implement appropriate prevention strategies.Disclosure of InterestNone Declared