bluuebunny/crossref_metadata_2025_split huggingface dataset:
A study of the turbulence within a spiralling vortex filament using proper orthogonal decomposition
Authors: Mula Swathi M. , Tinney Charles E. 
Published: March 2015

The stability and turbulence characteristics of a vortex filament emanating from a single-bladed rotor in hover are investigated using proper orthogonal decomposition (POD). The rotor is operated at a tip chord Reynolds number and tip Mach number of 218 000 and 0.23, respectively, and with a blade loading of $C_{T}/{\it\sigma}=0.066$. In-plane components of the velocity field (normal to the axis of the vortex filament) are captured by way of two-dimensional particle image velocimetry with corrections for vortex wander being performed using the ${\it\Gamma}_{1}$ method. The first POD mode alone is found to encompass nearly 75 % of the energy for all vortex ages studied and is determined using a grid of sufficient resolution to avoid numerical integration errors in the decomposition. The findings reveal an equal balance between the axisymmetric and helical modes during vortex roll-up, which immediately transitions to helical mode dominance at all other vortex ages. This helical mode is one of the modes of the elliptic instability. The spatial eigenfunctions of the first few Fourier-azimuthal modes associated with the most energetic POD mode is shown to be sensitive to the choice of the wander correction technique used. Higher Fourier-azimuthal modes are observed in the outer portions of the vortex and appeared not to be affected by the choice of the wander correction technique used.
Stratified turbulence forced with columnar dipoles: numerical study
Authors: Augier Pierre , Billant Paul , Chomaz Jean-Marc 
Published: March 2015

This paper builds upon the investigation of Augier et al. (Phys. Fluids, vol. 26 (4), 2014) in which a strongly stratified turbulent-like flow was forced by 12 generators of vertical columnar dipoles. In experiments, measurements start to provide evidence of the existence of a strongly stratified inertial range that has been predicted for large turbulent buoyancy Reynolds numbers $\mathscr{R}_{t}={\it\varepsilon}_{\!K}/({\it\nu}N^{2})$, where ${\it\varepsilon}_{\!K}$ is the mean dissipation rate of kinetic energy, ${\it\nu}$ the viscosity and $N$ the Brunt–Väisälä frequency. However, because of experimental constraints, the buoyancy Reynolds number could not be increased to sufficiently large values so that the inertial strongly stratified turbulent range is only incipient. In order to extend the experimental results toward higher buoyancy Reynolds number, we have performed numerical simulations of forced stratified flows. To reproduce the experimental vortex generators, columnar dipoles are periodically produced in spatial space using impulsive horizontal body force at the peripheries of the computational domain. For moderate buoyancy Reynolds number, these numerical simulations are able to reproduce the results obtained in the experiments, validating this particular forcing. For higher buoyancy Reynolds number, the simulations show that the flow becomes turbulent as observed in Brethouwer et al. (J. Fluid Mech., vol. 585, 2007, pp. 343–368). However, the statistically stationary flow is horizontally inhomogeneous because the dipoles are destabilized quite rapidly after their generation. In order to produce horizontally homogeneous turbulence, high-resolution simulations at high buoyancy Reynolds number have been carried out with a slightly modified forcing in which dipoles are forced at random locations in the computational domain. The unidimensional horizontal spectra of kinetic and potential energies scale like $C_{1}{\it\varepsilon}_{\!K}^{2/3}k_{h}^{-5/3}$ and $C_{2}{\it\varepsilon}_{\!K}^{2/3}k_{h}^{-5/3}({\it\varepsilon}_{\!P}/{\it\varepsilon}_{\!K})$, respectively, with $C_{1}=C_{2}\simeq 0.5$ as obtained by Lindborg (J. Fluid Mech., vol. 550, 2006, pp. 207–242). However, there is a depletion in the horizontal kinetic energy spectrum for scales between the integral length scale and the buoyancy length scale and an anomalous energy excess around the buoyancy length scale probably due to direct transfers from large horizontal scale to small scales resulting from the shear and gravitational instabilities. The horizontal buoyancy flux co-spectrum increases abruptly at the buoyancy scale corroborating the presence of overturnings. Remarkably, the vertical kinetic energy spectrum exhibits a transition at the Ozmidov length scale from a steep spectrum scaling like $N^{2}k_{z}^{-3}$ at large scales to a spectrum scaling like $C_{K}{\it\varepsilon}_{\!K}^{2/3}k_{z}^{-5/3}$, with $C_{K}=1$, the classical Kolmogorov constant.
Macro-size drop encapsulation
Authors: Maleki A. , Hormozi S. , Roustaei A. , Frigaard I. A. 
Published: March 2015

Viscoplastic fluids do not flow unless they are sufficiently stressed. This property can be exploited in order to produce novel flow features. One example of such flows is viscoplastically lubricated (VPL) flow, in which a viscoplastic fluid is used to stabilize the interface in a multi-layer flow, far beyond what might be expected for a typical viscous–viscous interface. Here we extend this idea by considering the encapsulation of droplets within a viscoplastic fluid, for the purpose of transportation, e.g. in pipelines. The main advantage of this method, compared to others that involve capillary forces is that significantly larger droplets may be stably encapsulated, governed by the length scale of the flow and yield stress of the encapsulating fluid. We explore this set-up both analytically and computationally. We show that sufficiently small droplets are held in the unyielded plug of a Poiseuille flow (pipe or plane channel). As the length or radius of the droplets increases, the carrier fluid eventually yields, potentially breaking the encapsulation. We study this process of breaking and give estimates for the limiting size of droplets that can be encapsulated.
Distance closures on complex networks
Authors: SIMAS TIAGO , ROCHA LUIS M. 
Published: March 2015

AbstractTo expand the toolbox available to network science, we study the isomorphism between distance and Fuzzy (proximity or strength) graphs. Distinct transitive closures in Fuzzy graphs lead to closures of their isomorphic distance graphs with widely different structural properties. For instance, the All Pairs Shortest Paths (APSP) problem, based on the Dijkstra algorithm, is equivalent to a metric closure, which is only one of the possible ways to calculate shortest paths in weighted graphs. We show that different closures lead to different distortions of the original topology of weighted graphs. Therefore, complex network analyses that depend on the calculation of shortest paths on weighted graphs should take into account the closure choice and associated topological distortion. We characterize the isomorphism using the max-min and Dombi disjunction/conjunction pairs. This allows us to: (1) study alternative distance closures, such as those based on diffusion, metric, and ultra-metric distances; (2) identify the operators closest to the metric closure of distance graphs (the APSP), but which are logically consistent; and (3) propose a simple method to compute alternative path length measures and corresponding distance closures using existing algorithms for the APSP. In particular, we show that a specific diffusion distance is promising for community detection in complex networks, and is based on desirable axioms for logical inference or approximate reasoning on networks; it also provides a simple algebraic means to compute diffusion processes on networks. Based on these results, we argue that choosing different distance closures can lead to different conclusions about indirect associations on network data, as well as the structure of complex networks, and are thus important to consider.
Maternal dietary patterns and gestational diabetes mellitus: a large prospective cohort study in China
Authors: He Jian-Rong , Yuan Ming-Yang , Chen Nian-Nian , Lu Jin-Hua , Hu Cui-Yue , Mai Wei-Bi , Zhang Rui-Fang , Pan Yong-Hong , Qiu Lan , Wu Ying-Fang , Xiao Wan-Qing , Liu Yu , Xia Hui-Min , Qiu Xiu 
Published: March 2015

Few studies have explored the relationship between dietary patterns and the risk of gestational diabetes mellitus (GDM). Evidence from non-Western areas is particularly lacking. In the present study, we aimed to examine the associations between dietary patterns and the risk of GDM in a Chinese population. A total of 3063 pregnant Chinese women from an ongoing prospective cohort study were included. Data on dietary intake were collected using a FFQ at 24–27 weeks of gestation. GDM was diagnosed using a 75 g, 2 h oral glucose tolerance test. Dietary patterns were determined by principal components factor analysis. A log-binomial regression model was used to examine the associations between dietary pattern and the risk of GDM. The analysis identified four dietary patterns: vegetable pattern; protein-rich pattern; prudent pattern; sweets and seafood pattern. Multivariate analysis showed that the highest tertile of the vegetable pattern was associated with a decreased risk of GDM (relative risk (RR) 0·79, 95 % CI 0·64, 0·97), compared with the lowest tertile, whereas the highest tertile of the sweets and seafood pattern was associated with an increased risk of GDM (RR 1·23, 95 % CI 1·02, 1·49). No significant association was found for either the protein-rich or the prudent pattern. The protective effect of a high vegetable pattern score was more evident among women who had a family history of diabetes (P for interaction = 0·022). These findings suggest that the vegetable pattern was associated with a decreased risk of GDM, while the sweets and seafood pattern was associated with an increased risk of GDM. These findings may be useful in dietary counselling during pregnancy.
Malignant phenotype and two SDHD mutations in a family with paraganglioma syndrome type 1
Authors: LEIDENZ FRANCIELE B. , BASTOS-RODRIGUES LUCIANA , OLIVEIRA MARCELO , MAMEDE MARCELO , SARQUIS MARTA , FRIEDMAN EITAN , DE MARCO LUIZ 
Published: March 2015

SummaryBackground: Paraganglioma syndrome type 1 (PGL1) is a rare autosomal dominant syndrome associated with multiple, overwhelmingly benign, pheochromocytomas and paragangliomas, attributed to SDHD gene mutations. Objective: Clinically and molecularly characterize a family with uncommon malignant phenotype of paragangliomas attributed to two seemingly pathogenic SDHD germline mutations. Materials & methods: The proband presented with large bilateral carotid body tumours and family history of cervical masses in his five siblings. All family members underwent clinical examination, imaging studies (18F-FDG PET/CT) and genotyping of relevant genes. The proband was diagnosed with locally advanced paraganglioma; his hypertensive, otherwise asymptomatic father, had locally advanced pheochromocytoma and his three siblings showed multiple head and neck masses, confirmed to be paragangliomas with local metastasis. All affected patients carried two germline mutations in the SDHD gene; a previously reported nonsense mutation in exon 1 (p.Trp5X) and a novel missense mutation in exon 2 (p.Pro53Leu), highly deleterious by in silico analysis. Allelic loss at the SDHD locus was not shown for any of the analysed tumours. Conclusions: This is a rare case of malignant PGL1 with seemingly double pathogenic mutations in the SDHD gene, highlighting the possibility that the presence of both mutations is associated with the more aggressive phenotype.
Environmental factors that affect the Fukuda stepping test in normal participants
Authors: Munnings A , Chisnall B , Oji S , Whittaker M , Kanegaonkar R 
Published: March 2015

AbstractBackground:The Fukuda stepping test is commonly used to assess peripheral vestibular function. It has, however, been suggested that its maximal sensitivity and specificity are 70 per cent and 50 per cent, respectively. This study was undertaken to evaluate environmental factors that may influence the reliability of this assessment and hence to ‘sharpen’ its use in a clinical setting.Methods:Forty-four participants aged between 20 and 43 years were asked to perform the Fukuda stepping test in both a standard clinic room and a soundproofed room under the following conditions in a randomised order: on the floor versus on foam; with and without a sound-localising source; and with and without ear defenders.Results:Significant differences in the extent of rotation were found when comparing the results obtained in several settings, including standing on the floor in a standard room versus a soundproofed room (p = 0.036), and standing on foam in a standard room versus a soundproofed room (p = 0.015).Conclusion:Our results suggest that certain alterations to the test environment may improve the sensitivity of this clinical examination.
A multi-centre audit of epistaxis management in England: is there a case for a national review of practice?
Authors: Hall A C , Blanchford H , Chatrath P , Hopkins C 
Published: March 2015

AbstractObjective:The ENT-UK Clinical Audit and Practice Advisory Group initiated a pilot audit to investigate variance in epistaxis management between six units nationwide.Method:All patients with a diagnosis of epistaxis who were admitted for in-patient care at six ENT departments between November 2011 and February 2012 were prospectively enrolled.Results:A total of 166 patients were included in the study. Variance was demonstrated between the six units in a number of the key outcome areas. Twenty-eight per cent of patients were identified as eligible for operative intervention for epistaxis in one unit, compared with only 12.5 per cent in another.Conclusion:There are measurable, patient-relevant outcomes to assess epistaxis management and these can highlight areas of potential improvement. This pilot audit gives a snapshot of modern practice, which shows variance between the six units assessed. A national audit may allow us to improve patient experience and maximise efficiency in delivering emergency care in our most common patient encounter.
Resilience and corpus callosum microstructure in adolescence
Authors: Galinowski A. , Miranda R. , Lemaitre H. , Paillère Martinot M.-L. , Artiges E. , Vulser H. , Goodman R. , Penttilä J. , Struve M. , Barbot A. , Fadai T. , Poustka L. , Conrod P. , Banaschewski T. , Barker G. J. , Bokde A. , Bromberg U. , Büchel C. , Flor H. , Gallinat J. , Garavan H. , Heinz A. , Ittermann B. , Kappel V. , Lawrence C. , Loth E. , Mann K. , Nees F. , Paus T. , Pausova Z. , Poline J.-B. , Rietschel M. , Robbins T. W. , Smolka M. , Schumann G. , Martinot J.-L. ,   the IMAGEN Consortium
Published: March 2015

BackgroundResilience is the capacity of individuals to resist mental disorders despite exposure to stress. Little is known about its neural underpinnings. The putative variation of white-matter microstructure with resilience in adolescence, a critical period for brain maturation and onset of high-prevalence mental disorders, has not been assessed by diffusion tensor imaging (DTI). Lower fractional anisotropy (FA) though, has been reported in the corpus callosum (CC), the brain's largest white-matter structure, in psychiatric and stress-related conditions. We hypothesized that higher FA in the CC would characterize stress-resilient adolescents.MethodThree groups of adolescents recruited from the community were compared: resilient with low risk of mental disorder despite high exposure to lifetime stress (n = 55), at-risk of mental disorder exposed to the same level of stress (n = 68), and controls (n = 123). Personality was assessed by the NEO-Five Factor Inventory (NEO-FFI). Voxelwise statistics of DTI values in CC were obtained using tract-based spatial statistics. Regional projections were identified by probabilistic tractography.ResultsHigher FA values were detected in the anterior CC of resilient compared to both non-resilient and control adolescents. FA values varied according to resilience capacity. Seed regional changes in anterior CC projected onto anterior cingulate and frontal cortex. Neuroticism and three other NEO-FFI factor scores differentiated non-resilient participants from the other two groups.ConclusionHigh FA was detected in resilient adolescents in an anterior CC region projecting to frontal areas subserving cognitive resources. Psychiatric risk was associated with personality characteristics. Resilience in adolescence may be related to white-matter microstructure.
Suffering and charity in the dark night of the soul
Authors: BUNGUM DONALD J. 
Published: March 2015

AbstractEleonore Stump's solution to the problem of suffering fails to show how God could be justified in permitting persons to suffer the dark night of the soul. In this article, I explain why and offer an amendment. I contend that a person who responds to the dark night in the right way experiences positive feedback between suffering and charity. This feedback not only enables the sufferer ultimately to attain his heart's desire but also explains why God is justified in permitting persons to suffer the dark night.
Hume on prophecy
Authors: MCSHANE PADDY JANE 
Published: March 2015

AbstractHume claims that his argument against miracles applies ‘without any variation’ to prophecies. While Hume's argument against miracles has been thoroughly examined in the philosophical literature, his claim that this argument works against prophecies has been left relatively unexplored. In this article I examine Hume's conception of ‘prophecy’ and I argue that it is flawed. I also argue, however, that Hume's argument against miracles does indeed apply to prophecies, but only if we amend Hume's conception of ‘prophecy’. I articulate and defend such an amendment.
Does divine hiding undermine Positive Evidential Atheism?
Authors: AIKIN SCOTT F. 
Published: March 2015

AbstractPositive Evidential Atheism is the two-part view that our available evidence sufficiently supports the belief that God does not exist and that God's non-existence is a morally good thing. Paul Moser's recent work (2012, 2013, 2014, and forthcoming) provides a case that Positive Evidential Atheism is undermined by ‘intentional divine elusiveness’. This essay defends Positive Evidential Atheism from Moser's objection along two lines: (1) Moser's undercutting argument does not respect the fact that the positivity and evidentiality claims of Positive Evidential Atheism are logically connected, and (2) positive atheists needn't be those from whom God has hidden.
The Effectiveness of Paid Services in Supporting Unpaid Carers’ Employment in England
Authors: PICKARD LINDA , KING DEREK , BRIMBLECOMBE NICOLA , KNAPP MARTIN 
Published: March 2015

AbstractThis paper explores the effectiveness of paid services in supporting unpaid carers’ employment in England. There is currently a new emphasis in England on ‘replacement care’, or paid services for the cared-for person, as a means of supporting working carers. The international evidence on the effectiveness of paid services as a means of supporting carers’ employment is inconclusive and does not relate specifically to England. The study reported here explores this issue using the 2009/10Personal Social Services Survey of Adult Carers in England. The study finds a positive association between carers’ employment and receipt of paid services by the cared-for person, controlling for covariates. It therefore gives support to the hypothesis that services for the cared-for person are effective in supporting carers’ employment. Use of home care and a personal assistant are associated on their own with the employment of both men and women carers, while use of day care and meals-on-wheels are associated specifically with women's employment. Use of short-term breaks are associated with carers’ employment when combined with other services. The paper supports the emphasis in English social policy on paid services as a means of supporting working carers, but questions the use of the term ‘replacement care’ and the emphasis on ‘the market’.
Pre-plasma effect on laser beam energy transfer to a dense target under conditions relevant to shock ignition
Authors: Pisarczyk T. , Gus'kov S.Yu. , Renner O. , Demchenko N.N. , Kalinowska Z. , Chodukowski T. , Rosinski M. , Parys P. , Smid M. , Dostal J. , Badziak J. , Batani D. , Volpe L. , Krousky E. , Dudzak R. , Ullschmied J. , Turcicova H. , Hrebicek J. , Medrik T. , Pfeifer M. , Skala J. , Zaras-Szydlowska A. , Antonelli L. , Maheut Y. , Borodziuk S. , Kasperczuk A. , Pisarczyk P. 
Published: March 2015

AbstractThis paper reports on properties of a plasma formed by sequential action of two laser beams on a flat target, simulating the conditions of shock-ignited inertial confinement fusion target exposure. The experiments were performed using planar targets consisting of a massive copper (Cu) plate coated with a thin plastic (CH) layer, which was irradiated by the 1ω PALS laser beam (λ = 1.315 μm) at the energy of 250 J. The intensity of the fixed-energy laser beam was scaled by varying the focal spot radius. To imitate shock ignition conditions, the lower-intensity auxiliary 1ω beam created CH-pre-plasma which was irradiated by the main beam with a delay of 1.2 ns, thus generating a shock wave in the massive part of the target. To study the parameters of the plasma treated by the two-beam irradiation of the targets, a set of various diagnostics was applied, namely: (i) Two-channel polaro-interferometric system irradiated by the femtosecond laser (~40 fs), (ii) spectroscopic measurements in the X-ray range, (iii) two-dimensional (2D)-resolved imaging of the Kαline emission from Cu, (iv) measurements of the ion emission by means of ion collectors, and (v) measurements of the volume of craters produced in a massive target providing information on the efficiency of the laser energy transfer to the shock wave. The 2D numerical simulations have been used to support the interpretation of experimental data. The general conclusion is that the fraction of the main laser beam energy deposited into the massive copper at two-beam irradiation decreases in comparison with the case of pre-plasma. The reason is that the pre-formed and expanding plasma deteriorates the efficiency of the energy transfer from the main laser pulse to a solid part of the targets by means of the fast electrons and the wave of an electron thermal conductivity.
HTA AND ITS LEGAL ISSUES: A FRAMEWORK FOR IDENTIFYING LEGAL ISSUES IN HEALTH TECHNOLOGY ASSESSMENT
Authors: Widrig Daniel , Tag Brigitte 
Published: March 2015

Objectives: Legal analysis can highlight important issues that are relevant when deciding whether a medical technology should be implemented or reimbursed. Literature and studies show that even though the law is an acknowledged part of health technology assessment (HTA), legal issues are rarely considered in practice. One reason for this may be the lack of knowledge about the diversity of legal issues that are relevant for HTA. Therefore, this contribution aims primarily to identify and then explain the relevant legal issues in HTA. This study offers a framework for identifying the legal issues in HTAs in different jurisdictions and provides a basis for further research.Methods: After extensive literature search, the authors review Swiss health law to identify legal issues that are relevant to HTA. The authors then categorize these legal issues using a framework with an inside and outside perspective. Finally, they explain a selection of these legal issues with several examples.Results: This study reveals numerous legal issues that are relevant for HTA and underlines the necessity of incorporating legal analysis in HTAs. The suggested perspectival framework in this study provides a basis to structure the legal analysis. The identified legal issues are relevant in other countries and the perspectival framework is transferable to other jurisdictions.Conclusions: The article underlines the importance of in-depth discussion about the role of law in HTA. It provides a structured overview of the legal issues in HTA and suggests a development of more concrete instruments toward a standardized legal technology assessment.