bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beneficial effects of growth hormone-releasing hormone agonists on rat INS-1 cells and on streptozotocin-induced NOD/SCID mice
Authors: Zhang Xianyang , Cui Tengjiao , He Jinlin , Wang Haibo , Cai Renzhi , Popovics Petra , Vidaurre Irving , Sha Wei , Schmid Janine , Ludwig Barbara , Block Norman L. , Bornstein Stefan R. , Schally Andrew V. 
Published: November 2015

Significance
Improved therapeutic strategies for transplantation of pancreatic islet cells to selected patients with type-1 diabetes are urgently needed. Growth hormone-releasing hormone (GHRH) agonists to influence growth, function, and engraftment of islet cells were previously reported by us. This study demonstrates greater stimulation by improved GHRH agonists, on proliferation, gene expressions, and the signaling pathways in pancreatic β cells. Agonist MR-409 in vivo reduced the severity of streptozotocin-induced diabetes in nonobese diabetic severe combined immunodeficiency mice. Transplantation of rat islets preconditioned in vitro with MR-409 and its administration in vivo promoted growth, function, and engraftment of exogenous islets, supporting the use of GHRH agonists in type-1 diabetes. The beneficial effects of GHRH agonists on the functions of β cells may also provide approaches to their application in type-2 diabetes.
Electron cryotomography reveals ultrastructure alterations in platelets from patients with ovarian cancer
Authors: Wang Rui , Stone Rebecca L. , Kaelber Jason T. , Rochat Ryan H. , Nick Alpa M. , Vijayan K. Vinod , Afshar-Kharghan Vahid , Schmid Michael F. , Dong Jing-Fei , Sood Anil K. , Chiu Wah 
Published: November 2015

Significance
Platelets are known to be both numerically and functionally altered in some patients with cancer. However, structural differences in the platelets from these patients have not been studied. Here we use electron cryotomography to reveal that, compared with control donors, the microtubule system and the mitochondria of platelets from patients diagnosed with ovarian cancer are significantly different. This finding suggests the potential of electron cryotomography as a technology to detect structural biomarkers of diseases affecting platelets.
Role of vascular density and normalization in response to neoadjuvant bevacizumab and chemotherapy in breast cancer patients
Authors: Tolaney Sara M. , Boucher Yves , Duda Dan G. , Martin John D. , Seano Giorgio , Ancukiewicz Marek , Barry William T. , Goel Shom , Lahdenrata Johanna , Isakoff Steven J. , Yeh Eren D. , Jain Saloni R. , Golshan Mehra , Brock Jane , Snuderl Matija , Winer Eric P. , Krop Ian E. , Jain Rakesh K. 
Published: November 2015

Significance
Emerging evidence indicates patients who benefit from antiangiogenic therapies have improved vessel function. To determine how bevacizumab modulates vessel morphology to improve vessel function we conducted a phase II trial of preoperative bevacizumab followed by bevacizumab combined with chemotherapy in HER2-negative breast cancer patients. Our results suggest that the clinical response to bevacizumab may occur through an increase in the extent of vascular normalization primarily in patients with a high baseline tumor microvessel density. If validated, these observations suggest approaches to improve antiangiogenic therapy and to identify patients likely to benefit.
Incorporating historical data into aquaculture planning
Authors: Alleway Heidi K. , Thurstan Ruth H. , Lauer Peter R. , Connell Sean D. 
Published: November 2015

Abstract
Marine historical research has made progress in bridging the gap between science and policy, but examples in which it has been effectively applied remain few. In particular, its application to aquaculture remains unexplored. Using actual examples of natural resource management in the state of South Australia, we illustrate how historical data of varying resolution can be incorporated into aquaculture planning. Historical fisheries records were reviewed to identify data on the now extinct native oyster Ostrea angasi fishery throughout the 1800 and early-1900s. Records of catch, number of boats fishing, and catch per unit effort (cpue) were used to test fishing rates and estimate the total quantity of oysters taken from select locations across periods of time. Catch quantities enabled calculation of the minimum number of oysters per hectare for two locations. These data were presented to government scientists, managers, and industry. As a result, interest in growing O. angasi increased and new areas for oyster aquaculture were included in regulatory zoning (spatial planning). Records of introductions of the non-native oyster Saccostrea glomerata, Sydney rock oysters, from 1866 through 1959, were also identified and used to evaluate the biosecurity risk of aquaculture for this species through semi-quantitative risk assessment. Although applications to culture S. glomerata in South Australia had previously been declined, the inclusion of historical data in risk assessment led to the conclusion that applications to culture this species would be accepted. The examples presented here have been effectively incorporated into management processes and represent an important opportunity for the aquaculture industry in South Australia to diversify. This demonstrates that historical data can be used to inform planning and support industry, government, and societies in addressing challenges associated with aquaculture, as well as natural resource management more broadly.
Big Cypress fox squirrel ( Sciurus niger avicennia ) ecology and habitat use in a cypress dome swamp-pine forest mosaic
Authors: Kellam John O. , Jansen Deborah K. , Johnson Annette T. , Arwood Ralph W. , Merrick Melissa J. , Koprowski John L. 
Published: November 2015

AbstractForested wetlands are in decline, as are many species that are obligate residents. Big Cypress fox squirrels (BCFS; Sciurus niger avicennia ) are a threatened endemic to wet pine and cypress forests in southwestern Florida. The region is characterized by development resulting in habitat loss, habitat fragmentation, and hydrological change that influence the quality of these wet forests. Through radiotelemetry and field observations, we examined the ecology and habitat use of BCFS in a natural cypress dome-pine forest mosaic. BCFS selected cypress domes for food and nests throughout the year. Cypress dome habitats were the only habitat type to be used more than available; however, the availability of nearby pine forest was also important. Home ranges were large relative to other tree squirrels, with male home ranges exceeding female ranges. Males overlapped more females than males, while sharing similar food preferences and use patterns with females, suggesting that the sexual dimorphism in home range size is related to mate searching. Roads and oil extraction pads were used less frequently than expected and were incorporated into home ranges less than randomly generated features. The importance of cypress domes within the wet forests and grasslands of Big Cypress National Preserve demonstrates the value of maintaining this delicate mosaic.
Comparison of Epidural or Regional Analgesia and Patient-controlled Analgesia
Authors: van Boekel Regina L. M. , Vissers Kris C. P. , van de Vossenberg Glenn , de Baat-Ananta Mira , van der Sande Rob , Scheffer Gert Jan , Steegers Monique A. H. 
Published: November 2015

Objectives:
A large number of patients still experience pain after surgery. This study investigates if epidural or regional analgesia (continuous infusion peripheral nerve blocks [CPNB]) provide superior pain relief compared with patient-controlled analgesia (PCIA) and identifies the incidence of minor and major adverse effects or complications of these techniques.

Materials and Methods:
Prospectively collected data of postoperative patients from an online data registration system of a special dedicated nurse-based acute pain service were analyzed. The acute pain service consultations were documented from January 2008 to August 2013 in a university hospital in The Netherlands.

Results:
An analysis was applied on data of 12,399 consecutive patients. Results showed that patients who received epidural analgesia and CPNB reported lower pain scores than those who received PCIA, after undergoing the same procedures. In addition, pain scores at rest were significantly lower than movement-evoked pain scores, in abdominal surgery. Severe nausea was mostly observed in patients with PCIA and itching was most common in patients with epidural analgesia. Opioid-induced respiratory depression was found in 5 patients with PCIA.

Discussion:
Epidural analgesia and CPNB provide better pain relief to patients than PCIA, especially in dynamic pain scores of patients. Evaluating real patient data on every patient visit is important for further improvement of the quality of postoperative pain management. Pain scores may vary widely between patients with similar surgical procedures. Therefore, we recommend that future research focuses on personalized pain measurement and pain management, to improve clinical practice more intensely.
A model for allometric permeation in fractal branching channel net driven by capillary pressure
Authors: Fan Jie , Zhu Na , Liu Zhi , Cheng Qian , Liu Yong 
Published: November 2015

Purpose
– The purpose of this paper is to investigate the allometric permeation performance in fractal branching channel net driven by capillary pressure and analyze how the geometrical parameters of the branching channel net affect the permeability of the fluid transportation.

Design/methodology/approach
– An allometric permeation model is proposed based on the fractal theory by considering capillary pressure as the main driven force of fluid permeation.

Findings
– It is found that the permeability efficiency is a function of fractal dimension, bifurcation number, and number of branching level. Different fluid permeation efficiencies of the channel net can be obtained by changing the three parameters.

Originality/value
– The allometric permeation model established provides a better understanding of the permeation mechanism in fractal porous media which could further help with the design of bio-mimetic artificial materials.
Numerical simulation of flow field around the race car in case
Authors: Dang Tien Phuc , Gu Zhengqi , Chen Zhen 
Published: November 2015

Purpose
– The purpose of this paper is to gain a better understanding of the flow field structure around the race car in two cases: stationary wheel and rotating wheel. In addition, this paper also illustrates and clarifies the influence of wheel rotation on the aerodynamic characteristics around the race car.

Design/methodology/approach
– The author uses steady Reynolds-Averaged Navier-Stokes (RANS) equations with the Realizable k-ε model to study model open-wheel race car. Two cases are considered, a rotating wheel and stationary wheel.

Findings
– The results obtained from the study are presented graphically, pressure, velocity distribution, the flow field structure, lift coefficient (Cl) and drag coefficient (Cd) for two cases and the significant influence of rotating case on flow field structure around wheel and aerodynamic characteristics of race car. The decreases in Cd and Cl values in the rotating case for the race car are 16.83 and 13.25 per cent, respectively, when compared to the stationary case.

Originality/value
– Understanding the flow field structures and aerodynamic characteristics around the race car in two cases by the steady RANS equations with the Realizable k-ε turbulence model.
Pore-scale numerical investigations of fluid flow in porous media using lattice Boltzmann method
Authors: Gao Cheng , Xu Rui-Na , Jiang Pei-Xue 
Published: November 2015

Purpose
– Lattice Boltzmann method (LBM) is employed to explore friction factor of single-phase fluid flow through porous media and the effects of local porous structure including geometry of grains in porous media and specific surface of porous media on two-phase flow dynamic behavior, phase distribution and relative permeability. The paper aims to discuss this issue.

Design/methodology/approach
– The 3D single-phase LBM model and the 2D multi-component multi-phase Shan-Chen LBM model (S-C model) are developed for fluid flow through porous media. For the solid site, the bounce back scheme is used with non-slip boundary condition.

Findings
– The predicted friction factor for single-phase fluid flow agrees well with experimental data and the well-known correlation. Compared with porous media with square grains, the two-phase fluids in porous media with circle grains are more connected and continuous, and consequently the relative permeability is higher. As for the factor of specific porous media surface, the relative permeability of wetting fluids varies a little in two systems with different specific surface areas. In addition, the relative permeability of non-wetting fluid decreases with the increasing of specific surface of porous media due to the large flow resistance.

Originality/value
– Fluid-fluid interaction and fluid-solid interaction in the SC LBM model are presented, and schemes to obtain immiscible two-phase flow and different contact angles are discussed. Two-off mechanisms acting on the wetting fluids is proposed to illustrate the relative permeability of wetting fluids varies a little in two systems with different specific surface.
Rheological effects on the levelling dynamics of thin fluid films
Authors: Ahmed Gulraiz , Sellier Mathieu , Lee Yeaw Chu , Jermy Mark , Taylor Michael 
Published: November 2015

Purpose
– The purpose of this paper is to investigate numerically the effect of rheology on the leveling of thin fluid films on horizontal solid substrates.

Design/methodology/approach
– A mathematical model based on the lubrication approximation which defines non-Newtonian rheology using a Power-law model is presented. The rheology is described by two parameters: the consistency factor and the flow behavior index. The resulting highly non-linear coupled set of equations is discretized using Finite-Difference and the resulting algebraic system is solved via an efficient Multigrid algorithm.

Findings
– Importantly, the non-dimensionalization process leads to a pair of Partial Differential Equations which depends on one parameter only, the flow behavior index. The authors show that the consistency factor only affects the time scale of the leveling process, hence stretching or contracting the time line. Results for the leveling of sinusoidal perturbations of the fluid film highlights important differences between the leveling of shear-thinning and shear-thickening fluids. In a normalized time frame, the onset of leveling occurs earlier for the shear-thinning fluid than for the shear-thickening one. However, the dimensionless leveling rate is higher for the shear-thickening fluid than the shear-thinning one. This results in a “threshold thickness” which delimits two regimes: the shear-thinning fluid levels to a thickness above this threshold faster than the shear-thickening fluid but the opposite is true for a film thickness below this threshold. An important aspect of this study is the verification of the numerical implementation using the Method of Manufactured Solutions (MMS), a first in the context of thin film studies. The paper also highlights differences between the leveling of two-dimensional and three-dimensional thickness perturbations.

Originality/value
– The study of the leveling of disturbances at the free surface of a liquid film using a Power-law rheological model does not appear to have been covered in the literature. Also, the paper uses the MMS to test the validity of the implementation. This appears to be the first time it has been used in the context of the lubrication approximation. Finally, unlike most prior studies, the work does away with the planar assumption.
An empirical test of the accuracy of an attack graph analysis tool
Authors: Sommestad Teodor , Sandström Fredrik 
Published: November 2015

Purpose
– The purpose of this paper is to test the practical utility of attack graph analysis. Attack graphs have been proposed as a viable solution to many problems in computer network security management. After individual vulnerabilities are identified with a vulnerability scanner, an attack graph can relate the individual vulnerabilities to the possibility of an attack and subsequently analyze and predict which privileges attackers could obtain through multi-step attacks (in which multiple vulnerabilities are exploited in sequence).

Design/methodology/approach
– The attack graph tool, MulVAL, was fed information from the vulnerability scanner Nexpose and network topology information from 8 fictitious organizations containing 199 machines. Two teams of attackers attempted to infiltrate these networks over the course of two days and reported which machines they compromised and which attack paths they attempted to use. Their reports are compared to the predictions of the attack graph analysis.

Findings
– The prediction accuracy of the attack graph analysis was poor. Attackers were more than three times likely to compromise a host predicted as impossible to compromise compared to a host that was predicted as possible to compromise. Furthermore, 29 per cent of the hosts predicted as impossible to compromise were compromised during the two days. The inaccuracy of the vulnerability scanner and MulVAL’s interpretation of vulnerability information are primary reasons for the poor prediction accuracy.

Originality/value
– Although considerable research contributions have been made to the development of attack graphs, and several analysis methods have been proposed using attack graphs, the extant literature does not describe any tests of their accuracy under realistic conditions.
Combined effects of moisture and radiation on thermal performance of protective clothing
Authors: Fu Ming , Weng Wenguo , Yuan Hongyong 
Published: November 2015

Purpose– The purpose of this paper is to study the combined effects of moisture and radiation on thermal protective performance of protective clothing exposed to low level radiation.Design/methodology/approach– Using a sweating manikin, the effect of radiation and moisture on heat and moisture transfer was initially analyzed under the dry manikin with sweating rate of 100 g/(m2h) exposed to 2.5 kW/m2, and then studied at 200 and 300 g/(m2h) exposed to 2 and 3 kW/m2, respectively. Finally, the combined effects of thermal radiation and moisture were predicted by fitting the relationships among heat loss and wet skin surface temperature, with the sweating rate and radiation intensity.Findings– The results show that the heat loss and the wet skin surface temperature are affected by the combined effects of moisture and radiation, with two distinctly different trends. Heat loss from the manikin is increasing with the sweating rate, and decreasing with thermal radiation intensity. However, the wet skin surface temperature has an opposite situation.Originality/value– Two filling equations are given to present the relationships among heat loss and wet skin surface temperature, with the sweating rate and radiation intensity. With these two equations, the heat loss and the wet skin surface temperature when exposed to radiation can be predicted by only measuring the mean radiant and ambient temperatures and controlling the sweating rate.
Analysing effect of the factors on ultrasonic seam tensile properties of nonwoven fabrics by Nested Anova Design
Authors: Kayar Mahmut , Mistik Suleyman Ilker , Inan Deniz 
Published: November 2015

Purpose– The purpose of this paper is to investigate the factors effecting ultrasonic seam tensile properties.Design/methodology/approach– In this study, 100 percent polypropylene and 100 percent polyester spunbond and meltblown nonwoven fabrics were sewn by using ultrasonic sewing machine with different rollers which have two, three and four rows. Seam tensile properties of the sewn nonwoven fabrics were investigated. Four-Level Nested Anova Design was applied to the data by using Minitab 15 software program.Findings– Higher seam strength values were obtained by using four rows roller, PP fiber, spunbond fabric and 50 g/m2 fabric area density for all nonwoven fabrics. Statistical significance was found between fabric area density, roller rows and seam tensile strength properties and between fabric type, roller rows and seam elongation at break values.Originality/value– When the authors look at the studies related to ultrasonic sewing, several researchers studied on welding parameters of ultrasonic sewing but very limited studies were performed on assembling of nonwoven fabrics with ultrasonic sewing. Therefore effect of production methods of nonwoven fabrics on the properties of ultrasonic sewing such as seam strength and elongation at break should be investigated.
Local ventilation and wear response of working jackets with different fabric permeability
Authors: Ke Ying , Li Jun , Havenith George 
Published: November 2015

Purpose
– An experimental study was conducted to investigate the local ventilation (the right arm, the chest and the back) and wear response of three types of working jackets in different conditions. The relationship between the local ventilation and its related wear response was also explored. The paper aims to discuss these issues.

Design/methodology/approach
– A clothing local ventilation measuring system was developed based on the steady state method to measure the local ventilation of the right arm, the chest and the back. Separate wear trials were conducted to determine the local skin temperature, local microclimate temperature and humidity, clothing local surface temperature, heart rate (HR), eardrum temperature and subjective perceptions.

Findings
– The results indicated that the back part of the jacket had the highest ventilation, followed by the chest and the arm. Fabric permeability affected the local ventilation of the arm and the chest more than on the back. Clothing local surface temperature was significantly related to garment regions but not to fabric permeability. Back ventilation and back surface temperature, arm or chest ventilation and local microclimate humidity of the arm or chest, HR and back ventilation, local ventilation of the arm or the chest and its related thermal sensation, had significant linear relationships.

Originality/value
– The research will help to understand the relationship between the air exchange of the microclimate and the wear response, and thus gives some suggestions on garment design or selection, especially for the working garments.