bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gene expression and morphometric parameters of human bone biopsies after maxillary sinus floor elevation with autologous bone combined with Bio‐Oss® or BoneCeramic®
Authors: Caubet Jorge , Ramis Joana M. , Ramos‐Murguialday Mikel , Morey Miguel Á. , Monjo Marta 
Published: March 2014

AbstractObjectivesAlthough the clinical success of Bio‐Oss® and BoneCeramic® has been corroborated by histologic and histomorphometric findings, the biological events that occur during healing after maxillary sinus floor elevation (MSFE) are unknown. Here, we evaluated biopsies of grafted bone with a mixture of autologous bone and Bio‐Oss® or BoneCeramic® after two different healing time periods to understand the molecular process underlying bone formation after MSFE.Material and methodsSeven patients, following a bilateral split‐mouth design model and needing a MSFE to allow implant placement, were recruited for this study. Right or left sinuses were grafted with autologous maxillary bone combined either with Bio‐Oss® or BoneCeramic®, respectively. Twenty biopsies were taken at the time of implant insertion after 4–5 months or 6–8 months of MSFE, and analyzed by micro‐computed tomography (microCT) and gene‐expression analysis.ResultsMicroCT analysis revealed no differences in the morphometric parameters or BMD either after 4–5 months or 6–8 months of MSFE between Bio‐Oss® and BoneCeramic®. At molecular level, a higher expression of bone forming gene Runx2 was observed after 4–5 months of MSFE in the Bio‐Oss® compared with the BoneCeramic® group.ConclusionsOur results indicate that differences found at the molecular level between Bio‐Oss® and BoneCeramic® are not translated to important differences in the 3D microstructure and BMD of the grafted bone.
Peri‐implant evaluation in type 2 diabetes mellitus patients: a 3‐year study
Authors: Gómez‐Moreno Gerardo , Aguilar‐Salvatierra Antonio , Rubio Roldán Jerónimo , Guardia Javier , Gargallo Jordi , Calvo‐Guirado José Luis 
Published: March 2014

AbstractObjectiveThe aim of this study was to analyze the changes produced in peri‐implant tissues in type 2 diabetes mellitus patients with different glycemia levels, measured by monitoring glycated hemoglobin A1c (HbA1c), over a period of 3 years following dental implant placement.Materials and methodsSixty‐seven patients were divided into four groups according to their HbA1c levels: 21 patients in Group 1 (<6); 24 patients in Group 2 (6.1–8); and 11 patients in Group 3 (8.1–10) and Group 4 (>10.1). Each patient received one implant. All implants were placed in the anterior zone of the maxilla. The variables selected to assess the general state of patients' peri‐implant health were as follows: probing depth, bleeding on probing, and marginal bone loss.ResultsMarginal bone loss was found to increase in relation to increases in HbA1c levels. Bleeding on probing showed statistically significant differences between groups. When the peri‐implant area was probed, mean levels of bleeding varied from 0.43 in Group 1 at 1 year after implant surgery to 0.62 in Group 4 (P = 0.042 between the four study groups). After the second year, greater bleeding on probing was observed in Group 4 (0.63) in comparison with groups with lower HbA1c levels. Peri‐implant pocket depths presented values that were too low to be considered pathological and without statistically significant differences between the study groups.ConclusionImplant therapies for diabetic patients can be predictable, providing these patients fall within controlled ranges of glycemia over time, assessed by monitoring HbA1c levels.
Do insulation products of man‐made vitreous fibres still cause skin discomfort?
Authors: Lundgren Lennart , Moberg Cecilia , Lidén Carola 
Published: March 2014

SummaryBackgroundMan‐made vitreous fibres (MMVFs) are used in products for insulation and as reinforcement in materials. Contamination of the skin may arise through direct or indirect contact, and from the deposition of airborne fibres. The scientific basis regarding the effects on skin of MMVFs dates from 1970–1980.ObjectivesTo investigate whether currently used insulation MMVF products still cause skin discomfort.MethodsFocus group interviews and structured interviews were performed among workers engaged in insulation tasks and among do‐it‐yourself consumers with a recent experience of MMVF products.ResultsA majority of interviewees experienced skin discomfort when handling MMVF products. Complaints caused by traditional (yellow) glass fibre products were more severe than those caused by products of rock or slag wool fibres. The wrists, forearms, neck and face were the locations where the skin was most affected. The situations causing problems varied between occupational tasks, but working with the hands over the head or in narrow spaces were described as the worst situations. Building construction apprentices performed insulation tasks more often than senior workers.ConclusionsMMVF insulation products do still cause skin discomfort. Updated knowledge about people's experiences of work with such products should influence legislation.
Is there a problem with the status quo? Debating the need for standalone ethical guidelines for research with people who use alcohol and other drugs
Authors: Olsen Anna , Mooney‐Somers Julie 
Published: March 2014

AbstractIn 2011, the Australian National Health and Medical Research Council (NHMRC) initiated an inquiry to determine whether there is a need for expanded ethical guidance in the form of a discrete guidance document for alcohol and other drug (AOD) research. An issues paper was developed to frame the inquiry. AOD researchers, Human Research Ethics Committees and others were invited to discuss whether there are distinctive ethical issues facing researchers and Human Research Ethics Committees in the AOD setting. Based on the public submissions, the NHMRC recommended that no AOD research‐specific guidance is required. The inquiry and the NHMRC decision were not widely publicized, and we feel there is a need for further discussion. In order to do so, we have analysed the public inquiry submissions and described the central themes. Few submissions in the inquiry explicitly agreed AOD research warrants a specific guidance framework. Most were concerned that the NHMRC issues paper unfairly targeted people who use drugs as complex research participants. The inquiry highlights tensions around research governance and ethics review boards dealing with illicit and stigmatised behaviours. While we agree that a specific guidance framework for AOD research is not needed and could potentially be harmful and restrictive, we are concerned that the wholesale rejection of a guidance framework has closed the door to much needed debate. There remains, we argue, a need for alternative strategies and tools to support ethical research, inform and streamline institutional ethics approval, and engage and protect participants. [Olsen A, Mooney‐Somers J. Is there a problem with the status quo? Debating the need for standalone ethical guidelines for research with people who use AODs. Drug Alcohol Rev 2014;33:637‐642]
Comparison of endoscopic band ligation and endoclip closure of colonic perforation: Technical feasibility and efficacy in an ex vivo pig model
Authors: Lee Tae Hoon , Han Joung‐Ho , Jung Yunho , Lee Suck‐Ho , Kim Dae Hoon , Shin Ji Yun , Lee Tae Soo , Kim Myunghwan , Choi Seok‐Hwa , Kim Hyun , Park Seonmee , Youn Seijin 
Published: March 2014

Background and AimRecent reports have indicated several instances of successful treatment of bowel perforation by using endoscopic band ligation (EBL) when treatment with endoclipping is unsuccessful, but this salvage method has not been investigated in any prospective model. Herein we aimed to compare the technical feasibility and efficacy of EBL and endoclip use in intraluminal closure of colon perforation, in an ex vivo model.MethodsStandardized colonic perforations were created using fresh porcine colon and subsequently closed by full‐thickness interrupted sutures, endoclip (QuickClip2TM), or EBL. Each closure site was tested with compressed air by using a digital pressure monitor for evaluating leak pressure.ResultsNo significant differences were noted between the endoclip and EBL in leak pressures. Mean (± SD) pressures for air leakage from the perforations closed using the different devices were as follows: normal colon samples, 52.0 ± 13.2 mmHg; perforations closed with hand‐sewn sutures, 32.3 ± 8.3 mmHg; perforations closed with endoclipping, 53.5 ± 22.7 mmHg; and perforations closed with EBL, 50.4 ± 12.5 mmHg. Time taken for closure by EBL was significantly less than that for closure by endoclipping (3.2 ± 1.7 min vs 6.8 ± 1.3 min, P < 0.01). Further, the number of devices used to achieve complete closure in the EBL group was lower than that with endoclipping (1.6 ± 0.5 vs 3.7 ± 0.8, P < 0.01).ConclusionEndoluminal closure of a 1.5‐cm colon perforation with EBL decreased procedure time and was not inferior in leak pressure compared with endoclipping in this ex vivo porcine model.
Stylet penetration activities linked to the acquisition and inoculation of Candidatus Liberibacter solanacearum by its vector tomato potato psyllid
Authors: Sandanayaka W.R.M. , Moreno A. , Tooman L.K. , Page‐Weir N.E.M. , Fereres A. 
Published: March 2014

AbstractThe tomato potato psyllid (TPP), Bactericera cockerelli (Sulc) (Hemiptera: Triozidae), is the main vector of the bacterium Candidatus Liberibacter solanacearum (Lso), a major disease of solanaceous crops. Feeding of TPP is associated with Lso transmission. However, very little is known about the stylet penetration activities linked to acquisition and inoculation of Lso. The electrical penetration graph (EPG)‐DC system was used to monitor stylet penetration activities during acquisition and inoculation of Lso by individual TPP on tomato [Solanum lycopersicum L. (Solanaceae)]. Female TPP from Lso‐free and Lso‐infected colonies were used in acquisition and inoculation tests, respectively. In the acquisition tests, TPP were tested for Lso after EPG recording of their stylet penetration activities on Lso‐infected tomato shoots. In the inoculation tests, samples from the tomato plants on which the stylet penetration of Lso‐infected TPP had been recorded were tested for Lso infection. The relationships between qPCR results and the EPG waveforms (C, G, D, E1, and E2) representing the main stylet penetration activities performed by individual insects in inoculation and acquisition tests were investigated. Results confirmed that a single adult TPP is capable of infecting a plant with Lso. Our data suggest that acquisition of the bacteria occurs during phloem ingestion (E2), and inoculation is likely associated with salivation into the phloem sieve elements (E1). The durations of EPG parameters were not significantly different between Lso‐infected and Lso‐free TPP (later shown by qPCR) in acquisition tests. In inoculation tests, the durations of E1 or E2 recorded from TPP on Lso‐infected and Lso‐free plants that were later shown by qPCR were not significantly different. However, C was shorter on Lso‐infected plants than on Lso‐free plants, where TPP performed phloem activities. The minimum plant access period required for Lso transmission by a single TPP was estimated to be ca. 2 h, with an acquisition threshold of about 36 min.
A review of 16 years of quality control parameters at a mass‐rearing facility producing Queensland fruit fly, Bactrocera tryoni
Authors: Fanson B.G. , Sundaralingam S. , Jiang L. , Dominiak B.C. , D'Arcy G. 
Published: March 2014

AbstractFrom 1996 to 2012, the mass‐rearing facility at Camden (NSW, Australia) has been producing Queensland fruit flies, Bactrocera tryoni (Froggatt) (Diptera: Tephritidae). During this time, the facility has regularly recorded fly quality parameters, creating a unique data set that provides an invaluable opportunity to evaluate the interrelationships among standard quality control (QC) parameters and test for redundant QC variables. Here, we conducted an exploratory data analysis to reveal relationships among the QC parameters. We found that pupal weight, adult lifespan, and longevity under nutritional stress (i.e., survival duration without food or water) had distinct monthly trends, suggesting that these QC parameters are sensitive to seasonal conditions. Furthermore, emergence percentage, flight ability, and adult lifespan were adversely affected by the dyeing/handling/irradiation process associated with sterile insect releases. Using a multivariate approach and controlling for monthly and yearly patterns, we showed that pupal weight and egg hatch are consistently negatively related and that percentage male and emergence rates are consistently negatively related. These results suggest that these correlation pairs measure similar quality information and hence one QC variable from each pair could be dropped. Flight ability was not strongly correlated with any of the QC variables, suggesting that this QC variable remains a useful QC metric. Finally, the longevity under nutritional stress QC appears to be fairly insensitive to QCs and we suggest that it should be replaced by the standard mortality under stress test.
The safety and acceptability of delivering an online intervention to secondary students at risk of suicide: findings from a pilot study
Authors: Robinson Jo , Hetrick Sarah , Cox Georgina , Bendall Sarah , Yung Alison , Pirkis Jane 
Published: March 2014

AbstractBackgroundSuicide‐related behaviour is a major problem among adolescents. Yet relatively few studies have tested the efficacy, acceptability and safety of interventions for this population. We developed and pilot tested an online intervention for at‐risk school students, which has led to reduced suicidal ideation, hopelessness and depressive symptoms. The aims of this study were to examine the safety and acceptability of the programme, and to determine which components were found to be most helpful and enjoyable.MethodsThis pilot study employed a pre‐test/post‐test design, with an 8‐week intervention phase. Participants were assessed immediately before, and immediately after the intervention. Participants were also asked to complete a weekly questionnaire immediately after the intervention, and again 2 days later assessing suicidal ideation and distress.ResultsTwenty‐one young people completed the intervention. Overall, the intervention did not lead to increases in suicidal ideation or distress. Participants reported enjoying the programme, in particular watching the video diaries and completing the activities, and said they would recommend the programme to a friend. Overall, the cognitive components of the programme were found to be most helpful.ConclusionsOverall, the programme appeared to be a safe and acceptable intervention for at‐risk adolescents. This was a small, pilot study so we need to interpret the results with caution. However, the findings are promising and suggest that young people at risk of suicide can safely be included in trials as long as adequate safety procedures are in place. The programme is now being tested in a randomized controlled trial.
Can an Internet‐based intervention reduce suicidal ideation, depression and hopelessness among secondary school students: results from a pilot study
Authors: Robinson Jo , Hetrick Sarah , Cox Georgina , Bendall Sarah , Yuen Hok Pan , Yung Alison , Pirkis Jane 
Published: March 2014

AbstractAimLittle evidence exists regarding the efficacy of suicide prevention programmes among the youth. This pilot study aimed to test the effects of a specifically designed, eight‐module Internet‐based programme on suicidal ideation among secondary school students.MethodsThe study employed a pre‐test/post‐test design. Outcomes of interest were suicidal ideation, depression and hopelessness. Participants were recruited via the school well‐being team, were assessed at baseline and immediately post‐intervention. The intervention was delivered weekly at the young persons' school.ResultsTwenty‐one students completed all eight modules and a post‐intervention assessment, and constitute the observed case sample used for the analysis. Overall levels of suicidal ideation, depressive symptoms and hopelessness decreased significantly over the course of the study.ConclusionsThis was a small pilot study with no control group. However, significant reductions were seen in suicidal ideation, depressive symptoms and hopelessness, indicating that Internet‐based interventions may hold promise when it comes to reducing suicide risk among youth. Further investigation is warranted.
Strategic manipulation of an industrial biocatalyst – evolution of a cephalosporin C acylase
Authors: Conti Gianluca , Pollegioni Loredano , Molla Gianluca , Rosini Elena 
Published: March 2014

Semi‐synthetic cephalosporins are synthesized from the 7‐amino cephalosporanic acid (7‐ACA) nucleus produced from the antibiotic cephalosporin C (CephC). In recent years, a single‐step enzymatic process in which CephC is directly converted into 7‐ACA by a cephalosporin C acylase (CA) has attracted industrial interest because of the prospects of simplifying the process and reducing costs. CAs are members of the glutaryl acylase family that specifically use CephC as their substrate; however, known natural glutaryl acylases show very low activity on the antibiotic. We previously enhanced the catalytic efficiency on CephC of a glutaryl acylase from Pseudomonas N176 (named VAC) by a protein engineering approach, and solved the structures of the VAC, thus providing insight into the substrate binding and catalytic activity of CAs. However, the properties of such enzymes are not sufficient to encourage 7‐ACA manufacturers to shift to single‐step enzymatic conversion of CephC. Here, we combine structural knowledge, semi‐rational design, computational approaches and evolution analysis to isolate VAC variants with altered substrate specificity (i.e. with a > 11 000‐fold increase in specificity constant for CephC versus glutaryl‐7‐amino cephalosporanic acid, compared to wild‐type) and with the highest kinetic efficiency so far obtained for a CA. Indeed, the H57βS‐H70βS‐L154βY VAC variant shows the highest conversion of CephC into 7‐ACA under conditions resembling those used at industrial level because of its high kinetic efficiency and the absence of substrate or product inhibition effects, and may be suitable for industrial application of the mono‐step process for CephC conversion.
Transnational healthcare seeking: how ageing Taiwanese return migrants view homeland public benefits
Authors: SUN KEN CHIH‐YAN 
Published: March 2014

AbstractIn this article, I argue that, by offering ageing return migrants new opportunities both to organize their lives and to rethink their social attachments, the extension of public healthcare in Taiwan constitutes a new contextual feature of the transnational social field bridging Taiwan and the USA. I use the concept of ‘transnational healthcare seeking’ to describe how returning seniors try to maintain their physical, psychological and social well‐being by accessing the benefits of public healthcare available in their homeland rather than in the USA. Furthermore, I offer the concept of ‘logics of social right’ to demonstrate how older returnees seek to reconfirm their social commitment to their homeland and to defend their entitlement to its state‐provided benefits against public criticism that they are free riders. In so doing, this article contributes a nuanced understanding of how ageing migrants imagine, pursue and construct an ideal later life across national borders.
Linking Sexism and Speciesism
Authors: Wyckoff Jason 
Published: March 2014

1.Some feminists and animal advocates defend what I call the Linked Oppressions Thesis, according to which the oppression of women and the oppression of animals are linked causally, materially, normatively, and/or conceptually. Alasdair Cochrane offers objections to several versions of the Linked Oppressions Thesis and concludes that the Thesis should be rejected in all its forms. In this paper I defend the Thesis against Cochrane's objections as well as objections leveled by Beth Dixon, and argue that the failure of these objections illuminates the idea of linked oppressions as well as misunderstandings of the Linked Oppressions Thesis, and may provide guidance to philosophers theorizing animal rights from a feminist perspective.
Consumer consumption intentions of smaller packaged snack variants
Authors: Payne Collin R. , Niculescu Mihai , Barney Chet E. 
Published: March 2014

AbstractSmaller snack package variants are ubiquitous in the food marketplace. Although it is assumed that consumers intend to consume less because snacks are placed into smaller packages, consumer intentions are never measured. This research examines dietary‐restrained consumers' consumption intentions of smaller snack package variants found in the marketplace described by snack type (i.e. less healthy, more healthy – as per Guiding Stars® food labelling system) and front‐of‐package calorie labelling (99 calories, 100 calories). We conducted an online experiment wherein 203 participants were exposed to the aforementioned snack package variants and their consumption intentions were subsequently measured. A regression analysis revealed that consumers who are highly dietary restrained intend to consume more when (a) the snack is relatively healthier and (b) it includes 99‐calorie front‐of‐package labelling. We discuss the idea that dietary‐restrained consumers are not likely to view smaller packaged snacks as portion control devices, but rather, as a means to eat more of a healthier food.
Angiographic Outcome of Endovascular Stroke Therapy Correlated with MR Findings, Infarct Growth, and Clinical Outcome in the DEFUSE 2 Trial
Authors: Marks Michael P. , Lansberg Maarten G. , Mlynash Michael , Kemp Stephanie , McTaggart Ryan A. , Zaharchuk Greg , Bammer Roland , Albers Gregory W. ,   for the DEFUSE Investigators
Published: March 2014

Background DEFUSE 2 demonstrated that patients with magnetic resonance imaging mismatch had a favorable clinical response to tissue reperfusion assessed by magnetic resonance imaging. This study reports the endovascular results and correlates angiographic reperfusion with clinical and imaging outcomes. Methods Prospectively enrolled ischemic stroke patients underwent baseline magnetic resonance imaging and started endovascular therapy within 12 h of onset. Patients were classified as either target mismatch or no target mismatch using magnetic resonance imaging. The pre- and postprocedure angiogram was evaluated to determine thrombolysis in cerebral infarction scores. Favorable clinical response was determined at day 30, and good functional outcome was defined as a modified Rankin Scale 0–2 at day 90. Results One-hundred patients had attempted endovascular treatment. At procedure end, 23% were thrombolysis in cerebral infarction 0–1, 31% thrombolysis in cerebral infarction 2A, 28% thrombolysis in cerebral infarction 2B, and 18% thrombolysis in cerebral infarction 3. More favorable thrombolysis in cerebral infarction-reperfusion scores were associated with greater magnetic resonance imaging reperfusion ( P < 0·001). thrombolysis in cerebral infarction scores correlated with 30-day favorable clinical response ( P = 0·041) and 90-day modified Rankin Scale 0–2 ( P = 0·008). These correlations were significant for target mismatch patients at 30 days ( P = 0·034) and 90 days ( P = 0·003). Infarct growth was strongly associated with poorer thrombolysis in cerebral infarction scores in target mismatch patients ( P < 0·001). Patients with thrombolysis in cerebral infarctionnfarction 2A reperfusion had less magnetic resonance imaging reperfusion ( P = 0·004) and poorer clinical outcome at 90 days ( P = 0·01) compared with thrombolysis in cerebral infarction 2B-3 patients. Conclusion Thrombolysis in cerebral infarction reperfusion following endovascular therapy for ischemic stroke is highly correlated with magnetic resonance imaging reperfusion, infarct growth, and clinical outcome.