bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the Influences of Sleep Disturbances in Mothers of School-Aged Children With Developmental Disabilities
Authors: Lee Jiwon , Hobbs Gerald , Spratling Regena 
Published: February 2025

Background: Although sleep is a modifiable health behavior linked to health and daytime functioning, studies have limited exploration of how mother and child-related factors interplay with mothers’ sleep disturbance in mothers of children with developmental disabilities. Objective: We aimed to explore the nature of sleep disturbances, their impact on health and daytime functioning, and strategies used to promote restful sleep in mothers of children with developmental disabilities. Methods: Using a qualitative descriptive approach, 13 mothers of school-aged children (6-12 years) with developmental disabilities who reported poor sleep quality completed semi-structured interviews. Interviews were transcribed, followed by thematic analysis. Results: Four themes were revealed: (1) I haven’t slept well in years; (2) My child doesn’t sleep well; (3) Being a mother of a child with a special need; and (4) Different strategies used to sleep better. Mothers reported chronic sleep disturbances that often started with the birth of their children and the negative effect of sleep disturbance on their health and daytime functioning. Mothers attributed their children with developmental disabilities’ sleep problems and chronic stress associated with daily caregiving as reasons for their sleep disturbances. Mothers tried various sleep-promoting activities to improve their sleep; they remained frustrated with not having consistent solutions and desired to learn specific strategies to manage sleep for themselves and their children. Conclusion: Our findings highlight the need to develop sleep health interventions, including strategies to reduce mothers’ stress and manage their children with developmental disabilities’ sleep problems, which may improve sleep and prevent adverse health outcomes.
The Safety and Tolerability of High Dose Intravenous Push Levetiracetam
Authors: Brandes Melissa , Flack Tara , Hays William B. 
Published: February 2025

Objective: Levetiracetam (LEV) is a guideline-recommended antiepileptic that has been shown to be effective in the termination of status epilepticus. Traditionally, LEV is diluted in 100 mL of compatible fluid and administered as an intravenous (IV) piggyback over 15-60 minutes. Recent data supports the administration of LEV as an undiluted IV push. However, there is limited literature supporting the safety and tolerability of undiluted IV push administration of high dose LEV (2500 mg to 4500 mg). The purpose of this study was to further investigate safety and tolerability of IV push levetiracetam at doses 2500 mg and greater. Methods: A retrospective chart review was conducted to evaluate adverse drug reactions following IV push administration of levetiracetam at a dose of 2500 mg or greater between the dates 8/5/2021 to 6/30/2022. During chart review, each patient was evaluated for any adverse events that occurred utilizing provider documentation, significant event forms, and/or allergy list documentation following administration of IV push LEV. Results: Throughout the study period, 340 doses of LEV 2500 mg and greater were evaluated. Most common total dose was 3000 mg and weight-based dose was 50-59.99 mg/kg. 119 doses of 4000 mg or greater were evaluated. 338/340 (99.4%) doses were considered to be well-tolerated. One patient experienced erythema at the injection site and another patient was noted to have nystagmus. Significance: This study adds to the body of literature that rapid administration of undiluted LEV, including doses of 2500 mg to 4500 mg is safe and tolerable.
A Novel Transapical Transcatheter Aortic Valve System for Treatment of Aortic Stenosis: A Single-Center Early Experience
Authors: Jin Ping , Guo Hong , Mao Yu , Zhai Mengen , Liu Yang , Yang Jian 
Published: February 2025

Background: Transcatheter aortic valve replacement (TAVR) has been widely used to treat patients with aortic stenosis (AS). The anchoring of most transcatheter heart valves (THV) depends on friction with the native aortic valve (AV). Methods: A total of 9 patients with severe AS accepted TAVR using Xcor system with transapical access in our center. Clinical outcomes were collected at baseline, before discharge, and at the 30-day follow-up. Results: All patients achieved procedural success, postprocedural transesophageal echocardiography showed that all of the patients had no/trace paravalvular leakage. The mean AV pressure gradient decreased from 50 mmHg (range 18-76 mmHg) to 10 mmHg (range 8-14 mmHg) ( P < .001). At the 30-day follow-up, all patients had an improvement of ⩾1 New York Heart Association functional class ( P < .001). The average 6-minute walk distance (377.2 [range 330.0-430.0] m vs 276.1 [range 245.0-320.0] m, P < .001) and Kansas City cardiomyopathy questionnaire score (53.4 [range 45.0-62.0] vs 38.9 [range 35.0-43.0], P < .001) were both improved. Conclusions: Our early experience shows that the Xcor system is safe and feasible in the treatment of patients with severe AS.
An Integrated Experimental-Simulation Calibration Method for the Constitutive Model of 6005A-T6 Aluminum Alloy Welds
Authors: Zhu Yu , Zhang Lele , Dou Weiyuan , Liu Wen 
Published: February 2025

Abstract
Due to the different microstructures caused by the heat source effect, welding joints exhibit significant differences in mechanical properties compared to the base material. Precise characterization of the constitutive characteristics of the welded joint requires a large number of repetitive experiments, which are costly, inefficient, and have limited accuracy improvements. This paper proposes an integrated experimental-simulation-based inverse calibration method, which establishes a calibration optimization problem based on the corresponding constitutive model and a finite element calculation model built by the distribution of hardness in the weldment. Using the global tensile force-displacement curve of the MIG-welded 6005A-T6 aluminum alloy specimen and the experimental data of local deformation with time change obtained from DIC (Digital Image Correlation), the parameters involved in the constitutive models are optimized accordingly. This method can directly obtain the constitutive characteristics of the weldment under conditions of limited experiments and insufficient data. Additionally, the adaptability of the constitutive model to the calibration method and the influence of optimization results are discussed and analyzed. The results indicate that the global force-displacement response of the non-saturated Ramberg-Osgood (R-O) model is in the best agreement with that of the experimental data, and the energy error is only 2.62%, followed by the MPL model, while the saturation-based Voce model shows the largest simulation error in terms of the presented object. Furthermore, the simulation results of R-O, Voce, and MPL models in the local area are far superior to traditional fitting methods.
The efficacy of low-intensity shock wave therapy based on the stratification of erectile dysfunction patients
Authors: Elshorbagy Galal , Elsayed Ahmed Salah , Elghoneimy Mohamed , Abdelrassoul Mohamed Abdo , Elkousy Mohamed Magdy , Ragab Mohamed Wael , Gharably Mohamed Aboul Fotouh El 
Published: February 2025

Abstract

Background
Low-intensity extracorporeal shockwave therapy (LI-ESWT) has a considerable positive influence on erectile function (EF) among individuals diagnosed with vasculogenic erectile dysfunction (ED).

Purpose
Our objective was to study the impact of LI-ESWT on several subcategories of ED and to determine the duration of the enhancement in EF by a comprehensive long-term follow-up.

Method
This was a retrospective study. Individuals diagnosed with vasculogenic ED received 6–12 sessions of LI-ESWT with 5000 impulses at a dosage of 0.01 j/mm2. The therapy was administered employing the electromagnetic Dornier Aries® 1 machine. Each patient underwent no less than six sessions of LI-ESWT. Subsequently, the participants had clinical assessment utilizing the International Index of Erectile Function (IIEF-EF) and the Erection Hardness Scores (EHS) domain score at 3 months following LI-ESWT, followed by assessments every 6 months. In addition, the penile blood flow dynamics were assessed 3 months after LI-ESWT and throughout the final follow-up examination.

Results
Forty-two individuals had been included, with a mean age of 50 ± 12 years. The median duration of ED was 31 (15–49) months, and the median follow-up duration was 24 months and IQR of 27 months. The initial IIEF-EF score had been 16 ± 6 and increased to 22 ± 6 after 3-month period, and then decreased to 21 ± 6 at the final follow-up (p < 0.01). A minimal clinically important difference (MCID) variation was observed in 69% of participants at 3 months and in 60% of the entire study population at the final follow-up. The factors of risk that were shown to be related with a greater likelihood of MCID at 3 months had been age (p = 0.01), uncontrolled diabetes mellitus (DM) ratio (p = 0.04), hypertension (p = 0.24), cardiovascular disease (p = 0.8), smoking (p = 0.63), and ex smoking (p = 0.3).

Conclusion
LI-ESWT shows promising long-term effectiveness in treating various degrees of ED, as demonstrated by the enhancement in penile blood flow observed during the final follow-up. This effect is particularly notable in individuals with well-managed DM and older age.
Awareness and perceptions of child maltreatment among medical students and interns: a cross-sectional study
Authors: Owaidah Sara , Alharaz Reham , Aljubran Sara , Almuhanna Zahra , AlMusailhi Jawaher , Abualait Turki , Al-sheikh Mona , Al Ghamdi Kholoud 
Published: February 2025

Abstract
Child maltreatment is an issue that burdens communities worldwide. Healthcare professionals, medical staff precisely, play a major role in the reporting responsibility, so it is crucial to ensure that none of the maltreatment cases are missed under medical supervision. This study aims to assess the awareness and perceptions of child maltreatment, and factors that affect reporting these cases among medical students and interns in the Eastern Province of Saudi Arabia. A self-administered questionnaire consisting of five categories (demographic data, the most prevalent form of child maltreatment, awareness and perceptions of child maltreatment, awareness of reporting policy, and factors that contribute to lack of reporting) was distributed among the participants electronically. Data were analyzed using a chi-square test along with frequency distribution of the independent variables. Out of 341 participants, 57.2% were females, and the majority were in their senior years. Less than half of the participants (41.9%) believed that the most common form of child maltreatment is physical abuse. Most participants had adequate awareness of both short- and long-term consequences of child maltreatment. However, they believed that community members did not have adequate awareness about the issue. One-third of the participants believed that they received adequate education on the topic during their training. Furthermore, 78.9% of the participants thought that child maltreatment is often missed. Most participants (90.9%) believed that reporting child maltreatment must be mandatory even if the injuries were not fatal. The top three factors that prevented physicians from reporting child maltreatment were lack of understanding of the reporting procedure, fear of destroying family relationships, and doubt of the occurrence of child maltreatment. Early training and exposure to child maltreatment cases is recommended for all healthcare professionals.
Acceptability and fidelity of the multidomain ‘Brain Bootcamp’ dementia risk reduction program: a mixed-methods approach
Authors: Siette Joyce , Dodds Laura , Brooks Cristy , Deckers Kay , Köhler Sebastian , Armitage Christopher J. 
Published: February 2025

Abstract

Background
Interventions targeting dementia prevention typically lack comprehensive exploration of feasibility, acceptability, and long-term translation factors prior to deployment. Our study aimed to explore the acceptability, fidelity and participants’ experiences with Brain Bootcamp, a multi-domain behaviour change intervention targeting reduced dementia risk and increased dementia risk factor awareness for older adults.

Methods
Conducted in New South Wales, Australia, from January to August 2021, our concurrent single-group mixed-methods feasibility study involved post-intervention surveys and qualitative interviews with community-dwelling older adults. Descriptive statistics were used to assess acceptability of the methods, outcome measures, and fidelity to the program components. Thematic analysis of semi-structured interviews explored participant experiences, preferences, barriers, and recommendations.

Results
Out of 853 enrolled participants, only 355 completed the program (41.6%). Among these participants, 79.1% agreed that the intervention improved their awareness of dementia risk factors, and 92.4% expressed intent to continue maintaining brain healthy behaviours post- program. Participants typically set 2–4 modifiable risk factor lifestyle goals, which were most often related to physical activity (83.7%). A majority (91.5%) successfully achieved at least one brain health goal. Qualitative analyses (n = 195) identified three overarching themes on the role of education on behaviour modification (i.e., the transformative role of the program in enhancing knowledge about dementia prevention and fostering behavioral modifications), psychological considerations (e.g., intrinsic versus extrinsic motivation on their engagement and perception of the program) and future directions (e.g., sustainability concerns and the need for tailored strategies for specific demographics).

Conclusions
While Brain Bootcamp had low completion rates, those who completed the program reported high acceptability. Future refinements, incorporating targeted strategies and enhanced participant support and communication, will facilitate pragmatic initiatives.

Clinical trial number
ACTRN12621000165886.
Nurses’ knowledge and their role in selected hospital logistics processes: a cross-sectional study
Authors: Jarosz Katarzyna , Czech Elżbieta , Jaromin Joanna 
Published: February 2025

Abstract

Introduction
Nursing as a profession is still changing, developing and seeking a place in the healthcare system. It also defines a new tasks and competencies in response to increasing patients’ needs and changing environment. Nursing tasks include not only strictly clinical tasks, but also non-nursing tasks that are necessary to carry out the treatment process such as logistics processes. The main aim of the study was to assess the level of knowledge of nurses about logistics processes and to assess the perception of the role of a nurse in selected hospital logistics processes. An additional objective was to assess the frequency of application of the 7R principle (the right product, in the right quantity, in the right condition, to the right place, at the right time, for the right customer/patient, at the right cost).

Materials and methods
This is a cross-sectional study. In the study, 152 nurses participated. The original questionnaire included a sociodemographic and logistical section, which consisted of questions about the definition of the logistics process and its understanding, respondents’ participation in logistics processes, and the occurrence of logistics processes in the workplace. The nurses’ knowledge was assessed through five questions, and the results could range from 1 to 6 points. Four questions were used to analyze the role of nurses in logistics processes, with possible scores ranging from 2 to 9 points. The frequency of the 7Rs principle usage ranged from 0 to 35 points.

Results
The level of respondents’ knowledge was moderate, with an average score of 4.67 points, and more than half of the nurses were characterized by a high level of knowledge about logistics processes (51.32%). The role of the nurse in the logistics process was assessed as moderately important, with a score of 5.91 points. The 7Rs principle was applied ‘sometimes,’ achieving a score of 26.67 points.

Conclusions
Although logistics as a science is not widely included in nursing education and practice, respondents reported a moderate level of knowledge and assessed the role of nurses in logistics processes as moderately significant, suggesting that logistics is important in the work of nurses.
Exploring perceptions of the services offered in Tanzanian sober houses: a mixed- methods study among service users and providers
Authors: Janson Samuel , Mushy Stella E. , McPherson Mecca , Mhando Frank , Jennings Mayo-Wilson Larissa , Iseselo Masunga K. , Saleem Haneefa , Kamwela Jerome , Issango Jumanne , Knox Justin , Mbita Gaspar , Madut Deng B. , Ostermann Jan , Thielman Nathan , Mwasa Betuel , Conserve Donaldson F. ,   BRIDGE Africa
Published: February 2025

Abstract

Background
In Tanzania, residential treatment centers for alcohol and other drugs, locally known as “sober houses,” play a critical role in the treatment of people living with a substance use disorder (SUD), but little is known about the services they offer and service users’ and providers’ perceptions of those services. We aimed to address these gaps in knowledge and to better understand where evidence-based interventions may be able to address gaps in service provision.

Materials and methods
This study used a mixed-methods approach across four sober houses in Dar es Salaam, Tanzania. We conducted 48 semi-structured interviews with a sub-sample of sober house service users (n = 38) and service providers (n = 10). Eighty-six (86) service users also completed a written survey to capture demographic information and assess knowledge of HIV and willingness to use HIV preventive care. All interviews were audio-recorded, translated into English, and then coded according to constructs developed with the Recovery Capital Framework. Following coding, a thematic analysis was conducted for the qualitative data using the framework developed by Braun and Clarke.

Results
Service users were generally positive about the treatment they were receiving but identified gaps in health service provision related to HIV, as well as a lack of preparation to address the employment-related challenges they face in the community after completing treatment. Service providers largely agreed with users’ perceptions of needs and identified a lack of clinical personnel in sober houses and funding challenges as barriers to meeting these needs.

Conclusion
Sober houses provide treatment services to Tanzanians with SUD that service users largely view as positive. This evaluation identified employment challenges after treatment completion and gaps related to HIV care in the sober house. Further research is needed to investigate how interventions can be adapted to the sober house setting to meet these needs.
miR-200c inhibition and catalase accelerate diabetic wound healing
Authors: D’Agostino Marco , Sileno Sara , Lulli Daniela , De Luca Naomi , Scarponi Claudia , Teson Massimo , Torcinaro Alessio , De Santa Francesca , Cirielli Corrado , Furgiuele Sergio , Morrell Chris H. , Dellambra Elena , Odorisio Teresa , Lakatta Edward G. , Avitabile Daniele , Capogrossi M. C. , Magenta Alessandra 
Published: February 2025

Abstract

Background
Reactive oxygen species (ROS) are increased in diabetic conditions and play a causal role in diabetic foot ulcers (DFU). We previously showed that ROS up-regulate miR-200c expression, that in turns causes apoptosis, senescence, ROS upregulation and nitric oxide decrease, leading to endothelial disfunction.

Methods
The aim of this study is to dissect miR-200c role in DFU and to explore the potential role of anti-miR-200c and antioxidant catalase (CAT) in promoting wound healing (WH). miR-200c inhibition and CAT treatment were performed either in immortalized keratinocytes (HaCaT) or in primary fibroblasts (FBs) and keratinocytes (KCs) deriving from diabetic patients (pts) undergoing amputations. Primary cells deriving from pts undergoing saphenectomies were used as controls. The miR-200c blockade was performed either via lentiviral particles bearing an anti-miR-200c sequence or locked nucleic acid (LNA) anti-miR-200c oligos. Equine CAT was administered on cell medium. The WH assay was performed in vivo on diabetic (db/db) mice by a topical treatment with CAT and LNA anti-miR-200c on wounds dissolved in a Pluronic gel mixture, administered every three days.

Results
We found that miR-200c levels were increased by different stimuli known to induce ROS, such as ultraviolet radiation (UV), hydrogen peroxide (H2O2), and high glucose in HaCaT. miR-200c was also upregulated in skin biopsies, in FBs and KCs isolated from pts with DFU vs controls. Forced miR-200c expression induced ROS in both FBs and KCs, and CAT reduced it. miR-200c inhibition improved WH in HaCaT, both under basal conditions and after UV and H2O2 treatment, and the simultaneous treatment with CAT accelerated it. miR-200c inhibition accelerated WH in KCs of DFU pts, increasing its protein targets: sirtuin 1 (SIRT1), the transcription factors FOXO1 and ZEB1 and decreasing p66Shc phosphorylation at Ser-36, that is induced by ROS, and the co-treatment with CAT showed synergistic effects in reducing ROS and cytotoxicity. Interestingly, CAT treatment decreased miR-200c expression in FBs and KCs of DFU pts. Topical administration of anti-miR-200c and CAT in a WH model of diabetic mice accelerated closure.

Conclusions
Anti-miR-200c and CAT could be considered a novel treatment for DFU and, possibly, for other types of non-diabetic skin ulcers.