bluuebunny/crossref_metadata_2025_split huggingface dataset:
A methodological proposal to assist scenario-based design in the early stages of innovation projects
Authors: Nelson Julien , Buisine Stéphanie , Aoussat Améziane 
Published: November 2012

Résumé Les ergonomes sont de plus en plus sollicités pour intervenir dans les phases initiales des projets de conception innovante. Leur contribution s’appuie le plus souvent sur l’analyse d’activités existantes ou de situations permettant d’appréhender l’activité future des usagers (ex. simulations). Ceci repose sur les postulats que (a) l’énoncé initial du problème de conception permet d’identifier clairement des situations de référence pour décrire l’activité future, et (b) le concept de produit est suffisamment mûr pour permettre la production d’objets intermédiaires (maquettes, prototypes) dont l’usage pourra être analysé. Dans les étapes initiales de projets d’innovation, ces postulats ne sont pas toujours vérifiés. Les ergonomes peuvent alors être appelés dans les étapes idéatives du projet, pour proposer et examiner des concepts de produits et d’usages nouveaux. Dans cet article, nous évaluons l’apport d’outils empruntés à la résolution créative de problèmes et à la fiabilité industrielle pour générer et analyser des scénarios d’usage dans ce cadre. Lors de simulations de réunions de conception, nous avons invité des équipes pluridisciplinaires de concepteurs à anticiper les usages de deux produits innovants : une table interactive et un dispositif de prévention de la noyade infantile. Les participants travaillaient soit librement, soit en utilisant les méthodes du brainwriting et de la matrice de découverte, pour construire des scénarios. Ils généraient ensuite, suivant une méthode dérivée de l’analyse des modes de défaillance, de leurs effets et de leur criticité, des revendications (claims) pour la conception. à partir de l’analyse de traces écrites et orales de l’activité et d’un questionnaire ad hoc , nous avons évalué la performance créative et le ressenti des participants. Notre méthodologie originale associe une approche de l’analyse de l’activité répandue dans l’étude des activités de conception, avec le cadre théorique de la génération d’idées en groupe utilisé dans des travaux en psychologie de la créativité. Comme les autres métiers de la conception représentés (ingénieurs et designers industriels), les ergonomes ont pu générer des idées sur les usages futurs possibles des produits, mais leur expertise leur a permis d’en produire davantage. Les outils proposés montrent un besoin de structurer l’exploration d’usages dans les phases en amont du processus. Ils ont permis de meilleures performances chez les concepteurs travaillant sur la table interactive, mais les résultats ont été moins concluants pour le travail sur l’équipement de sécurité. L’AMDEC modifiée pourrait, enfin, permettre de répartir l’interprétation des scénarios sur plusieurs équipes de travail. Ces résultats, enfin, encouragent au développement d’une ergonomie prospective de l’innovation.
Développement d'un système d'assistance à la détection des usagers vulnérables pour véhicules industriels en milieu urbain
Authors: Tattegrain Hélène , Maincent Annick , Bruyas Marie-Pierre , Bonnard Arnaud 
Published: November 2012

Résumé La sécurité des usagers vulnérables une question importante en termes de santé publique : la plupart des accidents impliquant des camions et des usagers vulnérables dans des zones urbaines ont des conséquences dramatiques pour ces derniers. Le projet VIVRE2 ( anr 05- pdit ) avait pour objectif l’étude et la conception de solutions technologiques pour réduire significativement le nombre de ces accidents. Pour concevoir ce système, l’approche User Centred Design , basée sur les étapes itératives décrites par Maguire (2001), a été adoptée en incluant des créations d’outils pour pouvoir l’appliquer dans le contexte industriel. Une plate-forme d’intégration a été conçue pour réduire le temps d’intégration du système d’assistance dans l’environnement de simulateur de conduite et ainsi faciliter le processus itératif. De plus, un générateur de scénario dynamique a permis la conception en laboratoire d’un système d’assistance actif en prenant en compte l’ensemble des cas d’utilisation. Le contexte d’utilisation a été analysé selon le point de vue de conducteurs et selon celui des usagers vulnérables. Les spécifications ont été définies pour améliorer l’utilisation de système dans la tâche de conduite selon les contraintes de cette dernière (l’aspect temporel, la complexité, la demande attentionnelle). Le système, basé sur une technologie adaptative, a été développé en prenant en compte le comportement du conducteur pour adapter les alertes de l’Interface Humain-Machine et les commandes actives. Le système retenu a été évalué sur simulateur dynamique de conduite et a prouvé son acceptabilité par les conducteurs et son efficacité sur des situations critiques sélectionnées (il a permis d’éviter 89 % des situations potentiellement critiques sur simulateur).
A criterion to identify the equilibration time in lipid bilayer simulations
Authors: Porasso Rodolfo D. , López Cascales José J. 
Published: November 2012

With the aim of establishing a criterion for identifying when a lipid bilayer has reached steady state using the molecular dynamics simulation technique, lipid bilayers of different composition in their liquid crystalline phase were simulated in aqueous solution in presence of CaCl$_2$ as electrolyte, at different concentration levels. In this regard, we used two different lipid bilayer systems: one composed by 288 DPPC (DiPalmitoylPhosphatidylCholine) and another constituted by 288 DPPS (DiPalmitoylPhosphatidylSerine). In this sense, for both type of lipid bilayers, we have studied the temporal evolution of some lipids properties, such as the surface area per lipid, the deuterium order parameter, the lipid hydration and the lipid-calcium coordination. From their analysis, it became evident how each property has a different time to achieve equilibrium. The following order was found, from faster property to slower property: coordination of ions $\approx$ deuterium order parameter $>$ area per lipid $\approx$ hydration. Consequently, when the hydration of lipids or the mean area per lipid are stable we can ensure that the lipid membrane has reached the steady state.Received: 3 September 2012, Accepted: 24 October 2012; Edited by: M. C. Barbosa; DOI:http://dx.doi.org/10.4279/PIP.040005Cite as: R. D. Porasso, J. J. López Cascales, Papers in Physics 4, 040005 (2012)
Validating methods to determine walking rates of elephants within a zoological institution
Authors: Miller LJ , Andrews J , Anderson M 
Published: November 2012

AbstractMuch controversy surrounds the welfare of elephants within zoological institutions. Among the many concerns are lack of exercise and the prevention of sedentary health and welfare issues due to smaller exhibits in comparison to the home-range sizes for elephants in Africa and Asia. While many scientists have used GPS to examine distances travelled by wild elephants, there is currently little information on distance travelled by elephants within zoological institutions. In the wild, it is necessary to chemically immobilise elephants using a dart gun in order to put on or take off collars which are used to acquire GPS data. Within a zoological institution, elephants can be trained to wear a collar with a GPS device but this training can be time consuming and also dangerous depending on the level of expertise of animal care staff. However, training an elephant within a zoological institution to wear an anklet outfitted with a GPS device can be much safer and less time consuming. The purpose of the current research was to validate methods for examining the walking rates of elephants in a zoological facility. This included testing GPS units, examining walking rates of eight elephants at the San Diego Zoo Safari Park using collars and conducting trials on a subset of elephants wearing both a collar and anklet outfitted with GPS devices to determine reliability. The average distance travelled by eight African elephants(Loxodonta africana)within a 24-h period was 8.65 (± 0.64) km which corresponds to a rate of 0.360 (± 0.033) kph. Trials comparing anklets to collars were found to be highly reliable except on days when weather conditions were overcast or there was rainfall at the park. The methods used for the current study can be utilised in future studies to examine walking rates as a component of animal welfare for elephants or other large mammals within zoological institutions.
Concomitant Mitigation of VO6 Octahedron Distortion and Band Broadening in V2O3 for High‐Performing Flexible Supercapacitors
Authors: Xu Qingli , Zhong Haoyin , Zhang Qi , Xiong Ting , Yu Junchen , Wu Chao , Xi Shibo , Yu Zhigen , Zhou Mengjuan , Yang Xiaona , Wang Xiaopeng , Zhang Kun , Lee Wee Siang Vincent , Xue Junmin 
Published: June 2024

AbstractVanadium trioxide (V2O3) has emerged as one of the promising candidates for fiber‐shaped supercapacitors. However, irreversible redox behavior during prolonged cycling process has been commonly reported due to the intrinsically distorted VO6 octahedron in V2O3, which inevitably compromises its electrochemical capacitance. Herein, a strategy to simultaneously mitigate the distortion in VO6 octahedron and optimization of electronic structure in V2O3 is proposed by studying a Mo‐doped V2O3 modified stainless steel wire (Mo‐V2O3@SSW). The introduction of Mo dopants effectively tunes the V–O local environment, resulting in a substantial alleviation of the distortion in VO6 octahedron. The as‐prepared Mo‐V2O3 with a more regular VO6 octahedron exhibits highly reversible redox behavior, with negligible structural change after 10 000 cycles. Moreover, it is found that doping Mo into V2O3 leads to V 3d band broadening, which generates more electronic states around Fermi level, thereby significantly accelerating the electron transfer during redox processes. Consequently, Mo‐V2O3@SSW attains a capacitance of 774.4 mF cm−2 at 0.4 mA cm−2, with a capacitance retention of 85.49% after 10 000 cycles. And the integration of Mo‐V2O3@SSW supercapacitors, further showcases its strong applicability in wearable technologies. The comprehensive understanding of the structural–activity/stability relationship in this study offers a novel paradigm for developing flexible high‐performing supercapacitors.
Harnessing Bacterial Membrane Components for Tumor Vaccines: Strategies and Perspectives
Authors: Bai Zhenxin , Wang Xuanyu , Liang Tianming , Xu Guangyu , Cai Jinzhou , Xu Wei , Yang Kai , Hu Lin , Pei Pei 
Published: June 2024

AbstractTumor vaccines stand at the vanguard of tumor immunotherapy, demonstrating significant potential and promise in recent years. While tumor vaccines have achieved breakthroughs in the treatment of cancer, they still encounter numerous challenges, including improving the immunogenicity of vaccines and expanding the scope of vaccine application. As natural immune activators, bacterial components offer inherent advantages in tumor vaccines. Bacterial membrane components, with their safer profile, easy extraction, purification, and engineering, along with their diverse array of immune components, activate the immune system and improve tumor vaccine efficacy. This review systematically summarizes the mechanism of action and therapeutic effects of bacterial membranes and its derivatives (including bacterial membrane vesicles and hybrid membrane biomaterials) in tumor vaccines. Subsequently, the authors delve into the preparation and advantages of tumor vaccines based on bacterial membranes and hybrid membrane biomaterials. Following this, the immune effects of tumor vaccines based on bacterial outer membrane vesicles are elucidated, and their mechanisms are explained. Moreover, their advantages in tumor combination therapy are analyzed. Last, the challenges and trends in this field are discussed. This comprehensive analysis aims to offer a more informed reference and scientific foundation for the design and implementation of bacterial membrane‐based tumor vaccines.
Chirality‐Induced Magnet‐Free Spin Generation in a Semiconductor
Authors: Liu Tianhan , Adhikari Yuwaraj , Wang Hailong , Jiang Yiyang , Hua Zhenqi , Liu Haoyang , Schlottmann Pedro , Gao Hanwei , Weiss Paul S. , Yan Binghai , Zhao Jianhua , Xiong Peng 
Published: June 2024

AbstractElectrical generation and transduction of polarized electron spins in semiconductors (SCs) are of central interest in spintronics and quantum information science. While spin generation in SCs is frequently realized via electrical injection from a ferromagnet (FM), there are significant advantages in nonmagnetic pathways of creating spin polarization. One such pathway exploits the interplay of electron spin with chirality in electronic structures or real space. Here, utilizing chirality‐induced spin selectivity (CISS), the efficient creation of spin accumulation in n‐doped GaAs via electric current injection from a normal metal (Au) electrode through a self‐assembled monolayer (SAM) of chiral molecules (α‐helix l‐polyalanine, AHPA‐L), is demonstrated. The resulting spin polarization is detected as a Hanle effect in the n‐GaAs, which is found to obey a distinct universal scaling with temperature and bias current consistent with chirality‐induced spin accumulation. The experiment constitutes a definitive observation of CISS in a fully nonmagnetic device structure and demonstration of its ability to generate spin accumulation in a conventional SC. The results thus place key constraints on the physical mechanism of CISS and present a new scheme for magnet‐free SC spintronics.
Seasonal influences on the efficacy of anti–programmed cell death (ligand) 1 inhibitors in lung cancer
Authors: Cho Hyunsoon , Kwon Hoejun , Kim Se Hyun , Ahn Hyung‐Min , Choi Beom K. , Lee Geon Kook , Park Seog‐Yun , Lim Hyun‐ju , Hwang Jung‐Ah , Lim Jiyeon , Han Ji‐Youn , Lee Youngjoo 
Published: June 2024

AbstractBackgroundSeasonal variations in systemic immunity have been reported. This study aimed to evaluate whether seasonality affects the efficacy of anticancer immunotherapy.MethodsA total of 604 patients with lung cancer receiving single anti–programmed cell death (ligand) 1 (anti–PD‐[L]1) inhibitors from two prospective observational cohorts were screened. Primary outcomes were progression‐free survival (PFS) and overall survival (OS). Patients were classified into two groups according to the season when the treatment started: winter (November–February) and other seasons (March–October). Kaplan–Meier analysis and Cox proportional hazards models were fitted to evaluate the impact of seasonality on survival. For validation, propensity score matching was performed.ResultsA total of 484 patients with advanced non–small cell lung cancer were included. In an unmatched population, multivariable analysis demonstrated that the winter group (n = 173) had a significantly lower risk of progression or death from immunotherapy than the other group (n = 311) (PFS: hazard ratio [HR], 0.77 [95% confidence interval (CI), 0.62–0.96]; p = .018; OS: HR, 0.77 [95% CI, 0.1–0.98]; p = .032). In a propensity score–matched population, the winter group (n = 162) showed significantly longer median PFS (2.8 months [95% CI, 1.9–4.1 months] vs. 2.0 months [95% CI, 1.4–2.7 months]; p = .009) than the other group (n = 162). The winter group’s median OS was also significantly longer than that of the other group (13.4 months [95% CI, 10.2–18.0 months] vs. 8.0 months [95% CI, 3.6–8.7 months]; p = .012). The trend toward longer survival in the winter group continued in subgroup analyses.ConclusionsStarting an anti–PD‐(L)1 inhibitor in winter was associated with better treatment outcomes in patients with lung cancer compared to other seasons.
RDD2022: A multi‐national image dataset for automatic road damage detection
Authors: Arya Deeksha , Maeda Hiroya , Ghosh Sanjay Kumar , Toshniwal Durga , Sekimoto Yoshihide 
Published: June 2024

AbstractThe data article describes the Road Damage Dataset, RDD2022, encompassing of 47,420 road images from majorly six countries, Japan, India, the Czech Republic, Norway, the United States, and China. The dataset incorporates over 55,000 instances of road damage, specifically longitudinal cracks, transverse cracks, alligator cracks, and potholes. Designed to facilitate the development of deep learning methodologies for automated road damage detection and classification, RDD2022 was unveiled as part of the Crowd sensing‐based Road Damage Detection Challenge (CRDDC'2022), with a major contribution from the challenge winners. This challenge garnered global participation, urging researchers to propose solutions for automatic road damage detection in multiple countries. A noteworthy outcome of CRDDC'2022 was the emergence of a top‐performing model achieving a remarkable F1 Score of 76.9% for road damage detection in all six countries using RDD2022. This success underscores the dataset's practical applicability for municipalities and road agencies, enabling low‐cost, automatic monitoring of road conditions. Beyond its immediate utility, RDD2022 stands as a valuable benchmark for researchers in computer vision, geoscience, and machine learning, offering a rich resource for algorithmic evaluation in diverse image‐based applications, including classification and object detection. The latest big data cup, Optimized Road Damage Detection Challenge (ORDDC'2024), is also based on RDD2022, underscoring its continued relevance and pivotal role in current research and development endeavors.
Heat transfer analysis in open pan heat exchanger (OPHE) with different cross‐sections of conduits for jaggery processing
Authors: Kore Abhijeet N. , Wankhede Sagar R. , Lakade Sanjay S. 
Published: June 2024

AbstractIndia leads the world in jaggery production, with the jaggery industry being a vital rural‐based sector. The jaggery plants in the country face challenges in effectively utilizing energy, resulting in varying efficiency levels ranging from 20% to 65% across different plants. To address this, a modified approach employing open pan heat exchangers (OPHEs) in jaggery plants is proposed to enhance overall performance. The effectiveness of the heat exchanger (HE) relies on factors such as heat transfer coefficient (HTC), surface contact area, and temperature differences between surfaces and the warm liquid. Circular conduits are predominantly favored in HE design, but this study delves into the impact of conduit shapes specifically circular, semi‐circular, and square on the achievement of the HE. The study reveals that semi‐circular conduits outperform circular conduits by 25%–28% in terms of HTC, while square conduits show a 21%–24% improvement. Moreover, comparing the efficiency of a conventional open pan jaggery plant with a circular conduit OPHE and a modified version featuring semi‐circular conduits OPHE, significant improvements are noted. A one hp pump is enough to overcome the issue related to pumping power due to a change in conduit shape. Heat transfer rate (HTR) is very poor for circular conduit due to line contact, whereas HTR for semi‐circular conduit is 38%–39% better than the square conduit. Efficiency increases from 24.36% for the conventional open pan to 62.5% for the circular conduit and further to 83.22% for the semi‐circular conduit. Processing time for jaggery making also varies significantly, with 165 min for the conventional open pan, which is reduced by 33.33% for the circular conduit OPHE and 45.45% for the semi‐circular conduit OPHE. As compared to circular conduit processing time of semicircular conduit OPHE is reduced by 18.18%.
Global left ventricular myocardial work: A novel method to assess left ventricular myocardial function and predict major adverse cardiovascular events in maintenance hemodialysis patients
Authors: Guo Yao , Tan Xiao , Li Zheng , Dai Chenchen , Yang Qiang , Nie Yuxin , Cao Xuesen , Shu Xianhong , Pan Cuizhen , Sun Minmin 
Published: June 2024

AbstractBackgroundThe application value of myocardial work (MW) in evaluating myocardial function and predicting major adverse cardiovascular events (MACE) in maintenance hemodialysis (MHD) patients has not been fully explored.PurposeComparing noninvasive MW parameters between MHD patients and healthy controls, and further determining its value in predicting MACE in MHD patients.MethodsA prospective single‐institution study included 92 MHD patients without prior cardiovascular disease and 40 age‐ and sex‐matched healthy controls. Conventional echocardiographic data, global longitudinal strain (GLS), and MW parameters (global work index [GWI], global constructive work [GCW], global work efficiency [GWE], global wasted work [GWW]) were derived and compared between MHD and the control. Logistic regression was used to determine the predictive value of these parameters for MACE. The receiver operating characteristic curve was utilized to compare the predictive differences of MACE between GWE and GLS.ResultsCompared with healthy individuals, MHD patients had significantly reduced GWE, GLS and elevated LVMI, GWW (all p < 0.001), while there was no significant difference in left ventricular ejection fraction. Twenty eight (30%) MHD patients experienced MACE. Two nested models adding GWE and GLS, respectively, showed that age (p < 0.005), GWE (p = 0.034), and GLS (p = 0.014) were independent predictors of MACE. The AUC derived from GWE for predicting MACE was significantly higher than that derived from GLS (0.836 vs. 0.743, p = 0.039).ConclusionsMyocardial work is a novel tool for assessing left ventricular myocardial performance in MHD patients. GWE is an independent predictor of MACE.
Long‐term success and influencing factors of regenerative surgery for intra‐bony defects: A retrospective cohort study
Authors: Huang Yan , Ouyang Xiangying , Liu Bei , Liu Jianru , Liu Wenyi , Xie Ying 
Published: June 2024

AbstractBackgroundThe composite outcome measure (COM) more comprehensively assesses the clinical efficacy of regenerative surgery than a single probing measurement. We aimed to assess long‐term success defined by the COM (clinical attachment level [CAL] gain of ≥3 mm and postsurgery probing pocket depth [PPD] ≤ 4 mm) and influencing factors of regenerative surgery using bone substitutes and resorbable collagen membrane (RM) for intra‐bony defects (IBDs).MethodsWe retrospectively collected data from patients who underwent regenerative surgery using deproteinized bovine bone mineral (DBBM) and RM for IBDs. CAL and PPD values were compared at baseline (preoperative), 1 year (short‐term), and at the last follow‐up (5–10 years). Multivariate logistic regressions were performed to identify factors influencing COM‐based long‐term success.ResultsEighty‐one defects in 75 teeth of 33 patients who completed follow‐up (6.5 ± 1.4 years) were included. One tooth was lost. All defects with complete follow‐up exhibited long‐term average CAL gain (3.00 ± 2.00 mm, 95% confidence interval [CI]: 2.56–3.44 mm, p < 0.001) and PPD reduction (2.06 ± 1.91 mm, 95% CI: 1.64–2.49 mm, p < 0.001). Long‐term success was achieved in 38.8% of IBDs. CAL and PPD values were comparable between 1 year and the last follow‐up. Logistic regression analyses revealed that male sex (odds ratio [OR] = 0.23, 95% CI: 0.07–0.75) and bleeding on probing (BOP) during supportive periodontal therapy (OR = 0.96, 95% CI: 0.94–0.99) were risk factors for long‐term success.ConclusionsRegenerative surgery with DBBM and RM for IBDs can achieve some degree of long‐term success defined by COM. However, within this study's limitations, male sex and higher BOP incidence postoperatively are negatively associated with optimal long‐term success.Clinical trial numberChiCTR2300069016.