bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomical and Procedural Features Associated With Aortic Root Rupture During Balloon-Expandable Transcatheter Aortic Valve Replacement
Authors: Barbanti Marco , Yang Tae-Hyun , Rodès Cabau Josep , Tamburino Corrado , Wood David A. , Jilaihawi Hasan , Blanke Phillip , Makkar Raj R. , Latib Azeem , Colombo Antonio , Tarantini Giuseppe , Raju Rekha , Binder Ronald K. , Nguyen Giang , Freeman Melanie , Ribeiro Henrique B. , Kapadia Samir , Min James , Feuchtner Gudrun , Gurtvich Ronen , Alqoofi Faisal , Pelletier Marc , Ussia Gian Paolo , Napodano Massimo , de Brito Fabio Sandoli , Kodali Susheel , Norgaard Bjarne L. , Hansson Nicolaj C. , Pache Gregor , Canovas Sergio J. , Zhang Hongbin , Leon Martin B. , Webb John G. , Leipsic Jonathon 
Published: June 2013

Background—
Aortic root rupture is a major concern with balloon-expandable transcatheter aortic valve replacement (TAVR). We sought to identify predictors of aortic root rupture during balloon-expandable TAVR by using multidetector computed tomography.

Methods and Results—

Thirty-one consecutive patients who experienced left ventricular outflow tract (LVOT)/annular/aortic contained/noncontained rupture during TAVR were collected from 16 centers. A caliper-matched sample of 31 consecutive patients without annular rupture, who underwent pre-TAVR multidetector computed tomography served as a control group. Multidetector computed tomography assessment included short- and long-axis diameters and cross-sectional area of the sinotubular junction, annulus, and LVOT, and the presence, location, and extent of calcification of the LVOT, as well. There were no significant differences between the 2 groups in any preoperative clinical and echocardiographic variables. Aortic root rupture was identified in 20 patients and periaortic hematoma in 11. Patients with root rupture had a higher degree of subannular/LVOT calcification quantified by the Agatston score (181.2±211.0 versus 22.5±37.6,
P
<0.001), and a higher frequency of ≥20% annular area oversizing (79.4% versus 29.0%,
P
<0.001) and balloon postdilatation (22.6% versus 0.0%,
P
=0.005). In conditional logistic regression analysis for the matched data, moderate/severe LVOT/subannular calcifications (odds ratio, 10.92; 95% confidence interval, 3.23–36.91;
P
<0.001) and prosthesis oversizing ≥20% (odds ratio, 8.38; 95% confidence interval, 2.67–26.33;
P
<0.001) were associated with aortic root contained/noncontained rupture.

Conclusions—
This study demonstrates that LVOT calcification and aggressive annular area oversizing are associated with an increased risk of aortic root rupture during TAVR with balloon-expandable prostheses. Larger studies are warranted to confirm these findings.
Ultrasound for Localization in Primary Hyperparathyroidism
Authors: Smith Russell B. , Evasovich Maria , Girod Douglas A. , Jorgensen Jeffrey B. , Lydiatt William M. , Pagedar Nitin A. , Spanos Willam C. 
Published: June 2013

ObjectiveTo evaluate the capability of ultrasound for preoperative localization in primary hyperparathyroidism.Study DesignProspective study.SettingMulti‐institutional Midwest Head and Neck Cancer Consortium.Subjects and MethodsTwo hundred twenty patients who underwent preoperative localization and had parathyroid surgery were evaluated. The findings of preoperative localization studies were correlated with surgical findings.ResultsPreoperative ultrasonography, sestamibi scintigraphy, or both were obtained in 77%, 93%, and 69% of the patients, respectively. Preoperative ultrasonography and sestamibi scintigraphy localized an abnormality in 71% and 79% of patients, respectively. At the time of surgery, the localization by ultrasound was accurate in 82%. The accuracy of localization was similar for sestamibi scintigraphy (85%). In patients with inaccurate ultrasound localization, the sestamibi scintigraphy correctly identified the site of disease in only 45%. In patients with a nonlocalizing ultrasound, sestamibi scintigraphy was able to localize disease in only 47%, with 2 being in the mediastinum.ConclusionsUltrasonography is an acceptable initial localization study for patients with primary hyperparathyroidism. In patients with nonlocalizing ultrasound, sestamibi scintigraphy should be obtained, but can be expected to detect an abnormality in less than 50% of patients.
Biomechanical Characteristics of Osteochondral Defects of the Humeral Capitellum
Authors: Mihata Teruhisa , Quigley Ryan , Robicheaux Grant , McGarry Michelle H. , Neo Masashi , Lee Thay Q. 
Published: June 2013

Background: The repetitive, excessive compression forces in the radiocapitellar joint caused by elbow valgus stresses during throwing motions can result in osteochondritis dissecans (OCD) of the humeral capitellum in adolescent athletes. Purpose: To assess the effect of elbow valgus torque on contact pressure in the radiocapitellar joint and that of central and lateral capitellar osteochondral defects on radiocapitellar joint contact pressure, elbow valgus laxity, and ulnar collateral ligament (UCL) strain. Study Design: Controlled laboratory study. Methods: In 8 matched pairs of fresh-frozen cadaveric upper limbs, lateral osteochondral defects of the humeral capitellum (5-, 10-, 15-, and 20-mm diameters) were evaluated in one side, and central defects were evaluated in the contralateral side. Radiocapitellar joint contact pressure, elbow valgus laxity, and UCL strain were all measured with and without 2 N·m of valgus torque at 30°, 60°, and 90° of elbow flexion in neutral forearm rotation. Results: Applying valgus torque increased contact pressure in radiocapitellar joints with intact or damaged capitula. Contact pressure in joints with 15-mm (90° of elbow flexion) and 20-mm (60° and 90° of elbow flexion) lateral capitellar defects was greater than that in joints with intact capitula. Radiocapitellar contact pressure was greater with a 20-mm lateral capitellar defect than in the same-sized central defect at 60° and 90° of elbow flexion. In both central and lateral defect groups, elbow valgus laxity increased as the size of the capitellar defect increased, and UCL strain remained unchanged regardless of the size of the capitellar defect. Conclusion: Elbow valgus torque increases contact pressure in the radiocapitellar joint. Capitellar osteochondral defects increase elbow valgus laxity and contact pressure without increasing UCL strain. When valgus torque is applied, contact pressure in the radiocapitellar joint is greater with a lateral defect than with a central defect. Clinical Relevance: Adolescent baseball players with capitellar OCD should stop throwing, even if the UCL is intact, to prevent exacerbating the osteochondral defect. Lateral capitellar OCD is more severe than central capitellar OCD.
Defining the Terms Acute and Chronic in Orthopaedic Sports Injuries
Authors: Flint James H. , Wade Alana M. , Giuliani Jeffrey , Rue John-Paul 
Published: June 2013

Background: Although many authors report on acute injuries and chronic injuries in the orthopaedic literature, the actual terms are seldom explicitly defined. Hypothesis: Much of the literature pertaining to sports injuries that are acute or chronic does not define these terms. It is believed that definitions will provide clarity and specificity in future literature. Study Design: Systematic review. Methods: A systematic review of 116 articles was conducted to determine whether and how the terms acute and chronic were defined as they pertain to several commonly treated conditions: Achilles tendon rupture, distal biceps tendon rupture, pectoralis major tendon rupture, anterior cruciate ligament (ACL) tear, anterior shoulder instability, and acromioclavicular (AC) joint dislocation. Articles were isolated from various databases and search engines by use of keywords to identify relevant literature. Results: This study determined that the terms acute and chronic for each injury are defined, respectively, as follows: Achilles tendon rupture: <1 week, >4 weeks; distal biceps tendon rupture: <6 weeks, >12 weeks; pectoralis major tendon rupture: <6 weeks, >6 weeks; ACL tear: <6 weeks, >6 months; anterior shoulder instability: <2 weeks, >6 months; AC joint dislocation, <3 weeks, >6 weeks. Conclusion: The current literature varies greatly in defining the terms acute and chronic in common sports injuries. The vast majority of authors imply these terms, based on the method of their studies, rather than define them explicitly. Injuries involving tendons showed greater consistency among authors, thus making a definition based on consensus easier to derive. The literature on ACL and shoulder instability in particular showed great variability in defining these terms, likely representing the more complex nature of these injuries and the fact that timing of surgery in the majority of patients does not particularly affect the complexity of the surgical approach and treatment. Clinical Relevance: Defining injuries as acute or chronic is clinically relevant in many cases, particularly concerning tendon injuries, where these terms have implications regarding the anatomic pathologic changes and tissue quality, which may necessitate augmentation and alter the initial surgical plan. In cases where these terms are less pertinent to operative treatment considerations, they bring clarity to the discussion of the acuity of the injury (as it pertains to time from insult).
An improved biofunction of Titanium for keratoprosthesis by hydroxyapatite-coating
Authors: Dong Ying , Yang Jingxin , Wang Liqiang , Ma Xiao , Huang Yifei , Qiu Zhiye , Cui Fuzhai 
Published: June 2013

Titanium framework keratoprosthesis has been commonly used in the severe corneal blindness, but the tissue melting occurred frequently around titanium. Since hydroxyapatite has been approved to possess a good tissue integration characteristic, nanostructured hydroxyapatite was coated on the surface of titanium through the aerosol deposition method. In this study, nanostructured hydroxyapatite coating was characterized by X-ray diffraction, scanning electron microscopy, atomic force microscopy, and auger electronic spectrometer. Biological evaluations were performed with rabbit cornea fibroblast in vitro and an animal model in vivo. The outcomes showed the coating had a grain-like surface topography and a good atomic mixed area with substrate. The rabbit cornea fibroblasts appeared a good adhesion on the surface of nanostructured hydroxyapatite in vitro. In the animal model, nanostructured hydroxyapatite-titanium implants were stably retained in the rabbit cornea, and by contrast, the corneal stroma became thinner anterior to the implants in the control. Therefore, our findings proved that nanostructured hydroxyapatite-titanium could not only provide an improved bond for substrate but also enhance the tissue integration with implants in host. As a promising material, nanostructured hydroxyapatite-titanium–based keratoprosthesis prepared by the aerosol deposition method could be utilized for the corneal blindness treatment.
Binge eating in obese adolescents: Emotional and behavioral characteristics and impact on health-related quality of life
Authors: Pasold Tracie L , McCracken Andy , Ward-Begnoche Wendy L 
Published: June 2013

Purpose: This study explored binge eating among an adolescent obese population to ascertain the prevalence of bingeing, the relationship between binge eating and body mass index (BMI), and to evaluate significant relationships between binge eating, emotional/behavioral functioning, and health-related quality of life. Methods: Participants included 102 overweight adolescents aged 12–17 years presenting to a multidisciplinary outpatient obesity clinic. Data obtained included height, weight, and self-report questionnaire data on emotional and behavioral functioning. Results: Binge eating prevalence included 33% moderate to severe binge eating. Binge eating was significantly positively related to BMI and depression, negative mood, feelings of ineffectiveness, negative self-esteem and significantly negatively related to somatic complaints and all aspects of health-related quality of life. Important demographic differences emerged with regard to the impact of binge eating on health-related quality of life with Caucasians, females, and older groups experiencing more pervasive impact. Conclusions: This research suggests that bingeing behaviors have pervasive and important implications for health-related quality of life for obese adolescents.
Association between eprosartan-based hypertension therapy and improvement in cognitive function score: long-term follow-up from the OSCAR observational study
Authors: Hanon Olivier , Lee Yong-Seok , Pathak Atul ,   on behalf of the OSCAR Publication Group
Published: June 2013

Objective: The Observational Study on Cognitive function And systolic blood pressure Reduction (OSCAR) was designed to evaluate the impact of eprosartan-based therapy on cognitive function in a cohort of 25,745 hypertensive subjects followed for six months. Methods: In this supplementary analysis, we studied the relationship between eprosartan-based therapy and cognitive function (assessed using the Mini-Mental State Examination (MMSE)) after 12-month follow-up of 3600 patients (the long-term follow-up on-treatment population). Results: Reduction in blood pressure was sustained over 12 months, with mean systolic blood pressure/diastolic blood pressure 130.9/79 mmHg at one year, compared with 164.3/92.8 mmHg at baseline ( p<0.001). The overall mean MMSE score at completion of 12-month follow-up was significantly increased from baseline (27.8±2.7 vs. 26.3±3.5; p<0.001). The increase in MMSE score was observed when the population was stratified by age ( p<0.001) and in a subgroup of patients with cerebrovascular disease at baseline ( n=290) ( p<0.001, 12 months vs. baseline). Conclusions: In this cohort of patients, use of eprosartan-based treatment for one year was associated with sustained reduction in blood pressure and stabilization or improvement of MMSE scores. These data are supportive of a role for blood pressure control in the prevention or delay of cognitive decline.
Association between angiotensin-converting enzyme I/D polymorphism and sepsis: A meta-analysis
Authors: Hou Xin , Zhang Pan , Nie Wei , Tang Shunjuan , Wang Jiuyan , Zhang Qiong , Wan Zhengdong , Zhang Botao , Song Bin 
Published: June 2013

Background: Previous studies investigating the association between the angiotensin-converting enzyme I/D polymorphism and sepsis have provided inconsistent results. Thus, a meta-analysis was performed to clarify the effect of the angiotensin-converting enzyme I/D polymorphism on sepsis risk and sepsis-related mortality. Methods: A comprehensive literature search was performed. Six case–control studies and two cohort studies were included in this meta-analysis. Odds ratios and corresponding 95% confidence intervals were estimated using random-effects models. Results: Pooled analysis of six case–control studies showed that there was a significant association between the angiotensin-converting enzyme I/D polymorphism and sepsis risk in a recessive genetic model (odds ratio = 0.75, 95% confidence interval 0.62–0.91, p = 0.004). However, no significant association between the angiotensin-converting enzyme I/D polymorphism and mortality was observed (odds ratio = 0.84, 95% confidence interval 0.57–1.24, p = 0.38). Conclusions: Our meta-analysis confirmed that the angiotensin-converting enzyme I/D polymorphism was associated with sepsis risk. However, the angiotensin-converting enzyme I/D polymorphism was not associated with sepsis mortality.
Passive maternal exposure to environmental microbes selectively modulates the innate defences of chicken egg white by increasing some of its antibacterial activities
Authors: Bedrani Larbi , Helloin Emmanuelle , Guyot Nicolas , Réhault-Godbert Sophie , Nys Yves 
Published: June 2013

Abstract

Background
Egg defence against bacterial contamination relies on immunoglobulins (IgY) concentrated in the yolk and antimicrobial peptides/proteins predominantly localized in the egg white (EW). Hens contaminated with pathogenic microorganisms export specific IgYs to the egg (adaptative immunity). No evidence of such regulation has been reported for the antimicrobial peptides/proteins (innate immunity) which are preventively secreted by the hen oviduct and are active against a large range of microbes. We investigated whether the egg innate defences can be stimulated by the environmental microbial contamination by comparing the antimicrobial activity of EW of hens raised in three extreme breeding conditions: Germ-free (GF), Specific Pathogen Free (SPF) and Conventional (C) hens.

Results
The difference in the immunological status of GF, SPF and C hens was confirmed by the high stimulation of IL-1β, IL-8 and TLR4 genes in the intestine of C and SPF groups. EW from C and SPF groups demonstrated higher inhibitory effect against Staphylococcus aureus (13 to 18%) and against Streptococcus uberis (31 to 35%) as compared to GF but showed similar activity against Salmonella Enteritidis, Salmonella Gallinarum, Escherichia coli and Listeria monocytogenes. To further investigate these results, we explored putative changes amongst the three main mechanisms of egg antimicrobial defence: the sequestration of bacterial nutrients, the inactivation of exogenous proteases and the direct lytic action on microorganisms. Lysozyme activity, chymotrypsin-, trypsin- and papain-inhibiting potential of EW and the expression of numerous antimicrobial genes were not stimulated suggesting that these are not responsible for the change in anti-S. aureus and anti-S. uberis activity. Moreover, whereas the expression levels of IL-1β, IL-8 and TLR4 genes were modified by the breeding conditions in the intestine of C and SPF groups they were not modified in the magnum where egg white is formed.

Conclusions
Altogether, these data revealed that the degree of environmental microbial exposure of the hen moderately stimulated the egg innate defence, by reinforcing some specific antimicrobial activities to protect the embryo and to insure hygienic quality of table eggs.
A unique midgut-associated bacterial community hosted by the cave beetle Cansiliella servadeii(Coleoptera: Leptodirini) reveals parallel phylogenetic divergences from universal gut-specific ancestors
Authors: Paoletti Maurizio G , Mazzon Luca , Martinez-Sañudo Isabel , Simonato Mauro , Beggio Mattia , Dreon Angelo Leandro , Pamio Alberto , Brilli Mauro , Dorigo Luca , Summers Engel Annette , Tondello Alessandra , Baldan Barbara , Concheri Giuseppe , Squartini Andrea 
Published: June 2013

Abstract

Background

Cansiliella servadeii (Coleoptera) is an endemic troglobite living in deep carbonate caves in North-Eastern Italy. The beetle constantly moves and browses in its preferred habitat (consisting in flowing water and moonmilk, a soft speleothem colonized by microorganisms) self-preens to convey material from elytra, legs, and antennae towards the mouth. We investigated its inner and outer microbiota using microscopy and DNA-based approaches.

Results
Abundant microbial cell masses were observed on the external appendages. Cansiliella’s midgut is fully colonized by live microbes and culture-independent analyses yielded nearly 30 different 16S phylotypes that have no overlap with the community composition of the moonmilk. Many of the lineages, dominated by Gram positive groups, share very low similarity to database sequences. However for most cases, notwithstanding their very limited relatedness with existing records, phylotypes could be assigned to bacterial clades that had been retrieved from insect or other animals’ digestive traits.

Conclusions
Results suggest a history of remote separation from a common ancestor that harboured a set of gut-specific bacteria whose functions are supposedly critical for host physiology. The phylogenetic and coevolutionary implications of the parallel occurrences of these prokaryotic guilds appear to apply throughout a broad spectrum of animal diversity. Their persistence and conservation underlies a possibly critical role of precise bacterial assemblages in animal-bacteria interactions.
An exploratory study of associations of physical activity with mental health and work engagement
Authors: van Berkel Jantien , Proper Karin I , van Dam Annelies , Boot Cécile RL , Bongers Paulien M , van der Beek Allard J 
Published: June 2013

Abstract

Background
Previous studies have found moderate to vigorous physical activity (MVPA) to be associated with a decreased risk of mental disorders. Although the focus in the field of psychology has shifted towards human strengths and optimal functioning, studies examining associations between MVPA and mental health in general (MH) and between MVPA and well-being are scarce. An indicator of work-related well-being is work engagement (WE). The aim of this study was to explore the associations between MVPA and MH, and between MVPA and WE.

Methods
In this study, a total of 257 employees from two research institutes, self-reported their MVPA, MH and level of WE. In addition, a randomly chosen subgroup (n=100) wore an Actigraph accelerometer for a 1-week period to measure their MVPA objectively. Crude and adjusted associations between MVPA and both WE and MH were analyzed using linear regression analyses.

Results
There was no statistically significant association between self-reported MVPA and mental health, resulting from both the crude (b=0.058, 95% CI -0.118 - 0.235) and adjusted analyses (b=0.026; 95% CI -0.158- 0.210), nor between objectively measured MVPA and mental health for both crude and adjusted analyses (b=-0.144; 95% CI -1.315- 1.027; b=-0.199; 95% CI 1.417- 1.018 respectively). There was also no significant association between self-reported MVPA and work engagement (crude: b=0.005; 95% CI -0.005-0.016, adjusted: b= 0.002; 95% CI -0.010- 0.013), nor between objectively measured MVPA and work engagement (crude: b= 0.012; 95% CI -0.084- 0.060, adjusted: b=0.007; 95% CI -0.083-0.069).

Conclusions
Although the beneficial effects of MVPA on the negative side of MH (i.e. mental disorders) have been established in previous studies, this study found no evidence for the beneficial effects of MVPA on positive side of MH (i.e. well-being). The possible difference in how the physical activity-mental health relationship works for negative and positive sides of MH should be considered in future studies.
Low fat intake is associated with pathological manifestations and poor recovery in patients with hepatocellular carcinoma
Authors: Yamada Kazuki , Suda Takeshi , Komoro Yuko S , Kanefuji Tsutomu , Kubota Tomoyuki , Murayama Toshiko , Nakayama Hideaki , Aoyagi Yutaka 
Published: June 2013

AbstractBackgroundThis study aimed to clarify whether dietary deviation is associated with pathological manifestations in hepatocellular carcinoma (HCC) patients.MethodsDietary intake was estimated in 35 HCC cases before and after hospitalization by referencing digital camera images of each meal. Pathological conditions were evaluated in nitrogen balance, non-protein respiratory quotient (npRQ), neuropsychiatric testing and recovery speed from HCC treatment.ResultsOn admission, nitrogen balance and npRQ were negative and less than 0.85, respectively. Five patients were judged to have suffered from minimal hepatic encephalopathy that tended to be associated with a lowered value of npRQ (p = 0.082). The energy from fat intake showed a tendency of positive correlation with npRQ (p = 0.11), and the patients with minimal hepatic encephalopathy took significantly fewer energy from fat (p = 0.024). The energy difference from fat between diets at home versus those in the hospital showed a significant positive correlation with npRQ change after admission (p = 0.014). The recovery speed from invasive treatments for HCC showed a significant negative correlation with npRQ alteration after admission (p = 0.0002, r = −0.73).ConclusionsThese results suggest the lower fat intake leads to deterioration of energy state in HCC patients, which associates with poor recovery from invasive treatments and various pathological manifestations.