bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect Of 4-Weeks Dutasteride Use On Perioperative Blood Loss In Patients Undergoing Transurethral Resection Of Prostate
Authors: Khattak Junaid Jamil , Shaikh Waqar Hassan , Ali Liaqat , Shaikh Aitzaz , Ur Rehman Shahzad 
Published: July 2024

ABSTRACT:
Background: Among old men, BPH is the most common urological illness. Medicinal and surgical treatments can be used. In medication, both 5-alpha reductase inhibitors and alpha-blockers are used. TURP, or transurethral resection of the prostrate, serves sufferers new to conventional therapy. They are 5-ARI aims to reduce the size and vascularity of the prostate in the meantime. The aim of this study was to investigate whether 5-ARI Dutasteride might reduce blood loss during TURP for BPH by drugs that block 5-ARI.
Objectives :The goal of this research was to see if preTURPitterside, a 5-alpha reeducates inhibitor (5-ARI), can reduce the amount of blood lost during surgery–TURP for benign prostatic hyperplasia (BPH)- in contrast and comparison. The postoperative hemoglobin levels for Dutasteride and non-Dutasteride groups having TURP were compared to determine if Dutasteride can reduce blood loss in TURP.
Study design: This Study is a prospective observational study.
Place and duration of the study: A prospective observational study was conducted from field the Institute of Kidney Diseases to December, 2019 at Hayatabad Medical Complex in Peshawar.
Methodology: A prospective observational study was conducted at the Institute of Kidney Diseases at Hayatabad Medical Complex, Peshawar, from field June to December 2019. Patients with TURP who met the inclusion criteria were divided into two groups according to whether they were taking drugs for BPH. The Dutasteride group took 0.5 mg/day of Dutasteride plus alpha-blocker(s), while the non-dutasteride group took alpha-blocker(s) only. A comparison was made of the difference between preoperative and postoperative haemoglobin levels in individuals taking TURP. A subsequent analysis was carried out using SPSS v23.0 to deduce the data.
Results: Postoperative haemoglobin levels were less likely to fall in those individuals who took Dutasteride for TURP than in the non-dutasteride group ( 0.75 mg/dl ± 0.4 VS where is the proof ? 1.3 mg/dl ± 0.4.）
Conclusion: Our research concludes that there is less haemoglobin decline when 5-ARI dutasteride 0.5 mg/day is used four weeks prior to surgery than when no dutasteride is used.
Keywords: Transurethral resection of the prostate, benign prostatic hyperplasia, 5-alpha reductase inhibitor, Dutasteride.
Analyzing 80 cases of conventional percutaneous nephrolithotomy A Retrospective Study
Authors: Waqas  , Nawaz Akhtar , Akbar Siddique , Alam Sardar , Anzanda Ikram 
Published: July 2024

Objective: The goal of this study is to provide information on the safety and efficacy of percutaneous nephrolithotomy as a kidney stone treatment method in tertiary care facilities.
Material and methods: A retrospective study was out from June 2022 to July 2023 at the urology department of the Ikd Peshawar This retrospective study included all patients who had percutaneous nephrolithotomy in the urology unit between June 2022 and July 2023. We analysed data that was retrospectively collected from the medical record system using IBM SPSS version 28.
Results: The study included 80 patients, with 67.3% being male and 32.7% being female. A kidney stone history was present in 55% of the patients. As a result of pre-operative ultrasound, 54.3% of patients had several stones, 40.1% had one stone, 3.7% had staghorn stones, 1.2% had a duplex system, and 0.6% (n=1) had a horseshoe kidney. The majority (60%), with stone sizes between 15 and 30 mm, were less than 15 mm, while a sizable minority (16.7%) were larger than 30 mm. Stones were most often found in the renal pelvis (46.3% of cases), lower pole (18.5% of cases), pelvis and lower pole together (16.3% of cases), and staghorn (7.3%). The average hemoglobin level dropped by 1.1 g/dl between pre- and post-operative measurements, from 12.9 g/dl to 11.8 g/dl.
Conclusion: A high clearance rate and manageable complication rate may be achieved using percutaneous nephrolithotomy, an efficient treatment for a variety of stone sizes and locations in the kidneys that are abnormal
The role of trade unions in Russia in ensuring the implementation of the constitutional principle of democracy
Authors: Goncharov Vitalii Viktorovich , Nagaitsev Viktor Valentinovich , Petrenko Elena Gennad'evna 
Published: July 2024

This article is devoted to the analysis of the role of trade unions in ensuring the implementation of the constitutional principle of democracy in the Russian Federation. The author substantiates the position that the implementation of this constitutional principle is impossible without a system of legal guarantees, among which the most important place is occupied by civil society institutions. The key and most developed institution of civil society in modern Russia are trade unions, which are voluntary public associations of citizens to protect their labor and social rights, which form the basis of the system of human and civil rights and freedoms in the Russian Federation. The article examines the main problems associated with the participation of trade unions in the implementation of forms of direct and indirect democracy in the country, and also developed and substantiated a system of proposals and recommendations to enhance the role of trade unions in ensuring the implementation of the constitutional principle of democracy in Russia. The work uses a number of methods of scientific research, in particular: analysis; synthesis; formal-logical; comparative-legal; historical-legal; statistical; sociological; method of analysis of specific legal situations. The most important place in this system is given to proposals to improve the Constitution of the Russian Federation and the current legislation in terms of increasing the role and place of trade unions in the mechanism of implementation of direct and indirect forms of democracy in Russia.The object of this study is public relations related to the implementation of the constitutional principle of democracy in Russia, as well as the participation of trade unions in this process. The subject of the study is a set of legal norms regulating the mechanism for ensuring the implementation of the constitutional principle of democracy, as well as scientific views on the place of trade unions in the organization and functioning of this mechanism. The purpose of this study is to identify and substantiate the role of trade unions in the Russian Federation in the mechanism of ensuring the implementation of democracy as the most important constitutional principle.
The Most Cited Articles in Resinous Infiltrates: A Bibliometric Analysis
Authors: Guimarães Ana Flávia César , Rocha Júlia de Oliveira , Torres Adriana da Silva , Martins Olga Beatriz Lopez , Torres Moisés de Matos , Araújo Cíntia Tereza Pimenta de 
Published: July 2024

Aims: To identify trends and growth in knowledge related to Resin Infiltrants, through a bibliometric review.
Study Design: Bibliometric review.
Methodology: A search was carried out in the Clarivate Analytics Web of Science database, using the terms (infiltrative resin OR resin infiltration) AND (white spot lesions OR white spots OR WSL OR Enamel demineralization OR orthodon* OR defect* OR hypoplas* OR discolor * OR dental fluorosis OR tooth demineralization OR calcification, tooth OR tooth discoloration OR dental enamel). Paired selection of manuscripts was carried out. The initial search identified 599 articles. After comparing titles and abstracts, the 50 most cited manuscripts involving Resinous Infiltrants were listed in order of classification.
Results: The most cited article in the top 50 was Frencken et al. in [1]. The earliest manuscript of this bibliometric analysis was published in 2001 by Robinson et al. in Caries Research and was cited 72 times, while two articles were the most recent, published in 2019 by Urquhart et al. in the Journal of Dental Research, it was cited 112 times and by Coelho Ased et al. in the Journal of Esthetic and Restorative Dentistry, cited 35 times. The citation distribution line shows high peaks in 2010 and 2012. The institutions that stood out the most were Charité Universitat Medizin Berlin, followed by Universitat zu Kiel. The main country was Germany. Among the main journals are the Journal of Dentistry and the publisher Elsevier. In total, 274 keywords were used. The period of 2010 was the period with the greatest concentration of publications and the most productive.
Conclusion: The bibliometric review carried out in this study revealed the growing interest and research around the use of Resinous Infiltrants as an effective and minimally invasive alternative to address white spot lesions and tooth decay.
LA LENGUA VIRAL:
Authors: Baudo Lorena Guadalupe 
Published: July 2024

Este trabajo explora el trasvase metafórico en torno a la pandemia del inglés al español, centrándose en las asociaciones culturales divergentes (Schäffner, 2004). El objeto de este estudio es proponer alternativas traslativas al orden metafórico imperante de enfermedad es guerra mediante la localización de metáforas conceptuales procedentes del Sur Global. El marco teórico entrecruza conceptos de los Estudios de Traducción como la modulación (Molina y Hurtado Albir, 2002), miradas localizadas frente a la globalización (Bauman, 1991) e ideas de la Semiótica de la Cultura, como modelización (Lotman, 2011) y orden de la cultura (Barei, 2006). Se lleva a cabo un análisis crítico-descriptivo de configuraciones textuales de amplia circulación y sus efectos retóricos. Se presentan resultados parciales: dos alternativas traductológicas localizadas, junto con sus expresiones lingüísticas y herramientas de reflexión para el/la traductor/a y de comunicación para el diálogo con actores del sector.
Multiplex Illumina Sequencing Using DNA Barcoding
Authors: Wong Koon Ho , Jin Yi , Moqtaderi Zarmik 
Published: January 2013

AbstractThe amount of sequence obtained by modern sequencing machines greatly exceeds the sequencing depth requirements of many experiments, especially those involving organisms with small genomes. In the interest of economy and efficiency, various strategies have been developed for multiplexing, in which samples are uniquely tagged with short identifying sequences known as barcodes, pooled, and then sequenced together in a single lane. The resulting combined sequence data are subsequently sorted by barcode before bioinformatic analysis. This unit contains a barcoding protocol for the preparation of up to 96 ChIP samples for multiplex sequencing in a single flow cell lane on the Illumina platform. This strategy may be extended to even larger numbers of samples and may also be generalized to other sequencing applications or sequencing platforms. Curr. Protoc. Mol. Biol. 101:7.11.1–7.11.11. © 2013 by John Wiley & Sons, Inc.
Using Phospho‐Motif Antibodies to Determine Kinase Substrates
Authors: White Colin D. , Toker Alex 
Published: January 2013

AbstractPhosphorylation of substrates by protein kinases regulates a myriad of cellular processes, ranging from proliferation and migration to autophagy, senescence, and apoptosis. Kinase substrate selectivity is largely dependent on the amino acid sequence surrounding the phosphorylation site; therefore, substrate‐directed, phosphorylation‐state‐sensitive, motif‐specific (“phospho‐motif”) antibodies represent powerful tools to identify novel kinase substrates and to investigate mechanisms of substrate phosphorylation in many signaling pathways typically associated with human malignancies. Phospho‐motif antibodies are engineered to recognize proteins that contain a phosphorylated residue in the context of a specific motif. They are raised against a library of phospho‐peptides comprising both the phosphorylated residue and the surrounding residues that determine kinase specificity, with degenerate residues taking up the remaining positions. Currently, several categories of phospho‐motif antibody are commercially available, which may be used to specifically detect Ser, Thr, Ser/Thr, or Tyr residues phosphorylated by different protein kinase families. These antibodies are commonly used in immunoprecipitation and/or immunoblotting protocols to determine kinase‐induced substrate phosphorylation. This unit describes the use of phospho‐motif antibodies to elucidate the kinase(s) responsible for phosphorylating substrate proteins. Curr. Protoc. Mol. Biol. 101:18.20.1–18.20.11. © 2013 by John Wiley & Sons, Inc.
Capture Hybridization Analysis of RNA Targets (CHART)
Authors: Simon Matthew D. 
Published: January 2013

AbstractThe genome is regulated by trans‐acting factors that bind to specific loci in chromatin. In addition to protein factors, it has become clear that large non‐coding RNAs can also act on chromatin at sites distant from where they are transcribed. This unit describes a means of identifying the genomic targets of those large non‐coding RNAs. To accomplish this, the endogenous RNA of interest (here Drosophila roX2 is used as an example) is enriched from cross‐linked chromatin extracts using short biotinylated complementary oligodeoxyribonucleotides. The targets of the RNA can be determined by examining the proteins and DNA that are enriched under these conditions. This analysis can be extended genome‐wide by subjecting the enriched DNA to deep sequencing. Curr. Protoc. Mol. Biol. 101:21.25.1–21.25.16. © 2013 by John Wiley & Sons, Inc.
Overview of DNA Microarrays: Types, Applications, and Their Future
Authors: Bumgarner Roger 
Published: January 2013

AbstractThis unit provides an overview of DNA microarrays. Microarrays are a technology in which thousands of nucleic acids are bound to a surface and are used to measure the relative concentration of nucleic acid sequences in a mixture via hybridization and subsequent detection of the hybridization events. This overview first discusses the history of microarrays and the antecedent technologies that led to their development. This is followed by discussion of the methods of manufacture of microarrays and the most common biological applications. The unit ends with a brief description of the limitations of microarrays and discusses how microarrays are being rapidly replaced by DNA sequencing technologies. Curr. Protoc. Mol. Biol. 101:22.1.1–22.1.11. © 2013 by John Wiley & Sons, Inc.
On the origins, rapid expansion and genetic diversity of native Americans from hunting‐gatherers to agriculturalists
Authors: Regueiro Maria , Alvarez Joseph , Rowold Diane , Herrera Rene J. 
Published: January 2013

AbstractGiven the importance of Y‐chromosome haplogroup Q to better understand the source populations of contemporary Native Americans, we studied 8 biallelic and 17 microsatellite polymorphisms on the background of 128 Q Y‐chromosomes from geographically targeted populations. The populations examined in this study include three from the Tuva Republic in Central Asia (Bai‐Tai, Kungurtug, and Toora‐Hem, n = 146), two from the northeastern tip of Siberia (New Chaplino and Chukchi, n = 32), and two from Mesoamerica (Mayans from Yucatan, Mexico n = 72, and Mayans from the Guatemalan Highlands, n = 43). We also see evidence of a dramatic Mesoamerican post‐migration population growth in the ubiquitous and diverse Y‐STR profiles of the Mayan and other Mesoamerican populations. In the case of the Mayans, this demographic growth was most likely fueled by the agricultural‐ and trade‐based subsistence adopted during the Pre‐Classic, Classic and Post‐Classic periods of their empire. The limited diversity levels observed in the Altaian and Tuvinian regions of Central Asia, the lowest of all populations examined, may be the consequence of bottleneck events fostered by the spatial isolation and low effective population size characteristic of a nomadic lifestyle. Furthermore, our data illustrate how a sociocultural characteristic such as mode of subsistence may be of impact on the genetic structure of populations. We analyzed our genetic data using Multidimensional Scaling Analysis of populations, Principal Component Analysis of individuals, Median‐joining networks of M242, M346, L54, and M3 individuals, age estimations based on microsatellite variation utilizing genealogical and evolutionary mutation rates/generation times and estimation of Y‐ STR average gene diversity indices. Am J Phys Anthropol, 2013. © 2013 Wiley Periodicals, Inc.
Brief communication: A pilot study: Smooth surface early caries (caries incipiens) detection with kavo diagnodent in historical material
Authors: Tomczyk Jacek , Komarnitki Iulian , Olczak‐Kowalczyk Dorota 
Published: January 2013

AbstractIn many odontological studies concerning archeological material, there is no analysis of early caries lesions (caries incipiens) that manifest as a carious spot. At this stage of caries, the enamel is still hard, and thus, it is impossible to diagnose caries by visual methods. We assessed the usefulness of the DIAGNODent pen (DD laser) in analyzing noncavity lesions on the smooth surface sites of crowns from historical populations. Twenty‐seven individuals were examined: 18 from Radom (Poland), and nine from Tell Masaikh and Terqa (Syria). A total of 562 teeth were characterized. The series represented different climatic zones, but were dated from the similar period, 18th to 19th century AD. We used four diagnostic techniques: visual, DD laser, radiographic, and histological as the gold standard. DD laser showed that the mean values of healthy enamel in both series did not exceed 15 units. The mean values of smooth and rough spots in the Syrian population were significantly higher than those from Poland. This study showed that all the noncarious spots from the Radom series did not exceed 30 units. In the Syrian samples, this limit was higher at 44 units. These results were confirmed by histology and radiography. The DD laser provided good results in detecting dentine carious lesions in historical material, but its efficiency in diagnosing early caries (caries incipiens) remains uncertain based on the presented series. Am J Phys Anthropol, 2013. © 2013 Wiley Periodicals, Inc.
Metamerism, morphogenesis, and the expression of carabelli and other dental traits in humans
Authors: Moormann Stephanie , Guatelli‐Steinberg Debbie , Hunter John 
Published: January 2013

AbstractThe patterning cascade model of tooth morphogenesis has emerged as a useful tool in explaining how tooth shape develops and how tooth evolution may occur. Enamel knots, specialized areas of dental epithelium where cusps initiate, act as signaling centers that direct the growth of surrounding tissues. For a new cusp to form, an enamel knot must form beyond the inhibition fields of other enamel knots. The model predicts that the number and size of cusps depends on the spacing between enamel knots, reflected in the spacing between cusps. Recently, work by our group demonstrated that the model predicted Carabelli trait expression in human first molars. Here we test whether differences in Carabelli trait expression along the molar row can also be predicted by the model. Crown areas and intercusp distances were measured from dental casts of 316 individuals with a digital microscope. Although absolute cusp spacing is similar in first and second molars, the smaller size and more triangular shape of second molars results in larger cusp spacing relative to size and, likely, less opportunity for the Carabelli trait to form. The presence and size of the hypocone (HY) and a range of small accessory cusps in a larger sample of 340 individuals were also found to covary with the Carabelli trait in a complex way. The results of this study lend further support to the view that the dentition develops, varies, and evolves as a single functional complex. Am J Phys Anthropol, 2013. © 2013 Wiley Periodicals, Inc.
Quality-of-care initiative in patients treated surgically for perforated peptic ulcer
Authors:   Danish Clinical Register of Emergency Surgery, Møller M H , Larsson H J , Rosenstock S , Jørgensen H , Johnsen S P , Madsen A H , Adamsen S , Jensen A G , Zimmermann-Nielsen E , Thomsen R W 
Published: January 2013

Abstract

Background
Mortality and morbidity are considerable after treatment for perforated peptic ulcer (PPU). Since 2003, a Danish nationwide quality-of-care (QOC) improvement initiative has focused on reducing preoperative delay, and improving perioperative monitoring and care for patients with PPU. The present study reports the results of this initiative.

Methods
This was a nationwide cohort study based on prospectively collected data, involving all hospitals caring for patients with PPU in Denmark. Details of patients treated surgically for PPU between September 2004 and August 2011 were reported to the Danish Clinical Register of Emergency Surgery. Changes in baseline patient characteristics and in seven QOC indicators are presented, including relative risks (RRs) for achievement of the indicators.

Results
The study included 2989 patients. An increasing number fulfilled the following four QOC indicators in 2010–2011 compared with the first 2 years of monitoring: preoperative delay no more than 6 h (59·0 versus 54·0 per cent; P = 0·030), daily monitoring of bodyweight (48·0 versus 29·0 per cent; P &lt; 0·001), daily monitoring of fluid balance (79·0 versus 74·0 per cent; P = 0·010) and daily monitoring of vital signs (80·0 versus 68·0 per cent; P &lt; 0·001). A lower proportion of patients had discontinuation of routine prophylactic antibiotics (82·0 versus 90·0 per cent; P &lt; 0·001). Adjusted 30-day mortality decreased non-significantly from 2005–2006 to 2010–2011 (adjusted RR 0·87, 95 per cent confidence interval 0·76 to 1·00), whereas the rate of reoperative surgery remained unchanged (adjusted RR 0·98, 0·78 to 1·23).

Conclusion
This nationwide quality improvement initiative was associated with reduced preoperative delay and improved perioperative monitoring in patients with PPU. A non-significant improvement was seen in 30-day mortality.
ChemInform Abstract: Hydrothermal Synthesis of New Rare Earth Silicate Fluorides: A Novel Class of Polar Materials.
Authors: McMillen Colin D. , Emirdag‐Eanes Mehtap , Stritzinger Jared T. , Kolis Joseph W. 
Published: January 2013

AbstractThe crystal structures of the new silicate fluorides (IV), (VI), and (VII) are determined by single crystal XRD.
ChemInform Abstract: Ba3LnInS6 (Ln: Pr, Sm, Gd, Yb) and Ba2LnGaS5 (Ln: Pr, Nd): Syntheses, Structures, and Magnetic and Optical Properties.
Authors: Feng Kai , Shi Youguo , Yin Wenlong , Wang Wendong , Yao Jiyong , Wu Yicheng 
Published: January 2013

AbstractThe title compounds are prepared by reaction of Ln (Ln: Pr, Nd, Sm, Gd, Yb), BaS, and In2S3 or Ga2S3 (evacuated silica tube, 1323 K, 48 h).
ChemInform Abstract: Synthesis, Structural Characterization, and ab Initio Study of Cu5+δIn2+xSb2‐x: A New B8‐Related Structure Type.
Authors: Mueller Carola J. , Lidin Sven , Ramos de Debiaggi Susana , Deluque Toro Crispulo E. , Fernandez Guillermet Armando 
Published: January 2013

AbstractCu5.33In2.29Sb1.71 is prepared from the elements (900 °C, 3 d, annealing at 300 °C for 30 d).
ChemInform Abstract: A Catalytic Asymmetric Ugi‐Type Reaction with Acyclic Azomethine Imines.
Authors: Hashimoto Takuya , Kimura Hidenori , Kawamata Yu , Maruoka Keiji 
Published: January 2013

AbstractIn the presence of axially chiral dicarboxylic acid BNDA as catalyst, 2‐benzoyloxyaryl isocyanides react with azomethine imines generated in situ from aldehydes and benzhydrazide (II), to give oxadiazine derivatives (IV).
ChemInform Abstract: Efficient Swern Oxidation and Corey—Kim Oxidation with Ion‐Supported Methyl Sulfoxides and Methyl Sulfides.
Authors: Tsuchiya Daisuke , Tabata Masayuki , Moriyama Katsuhiko , Togo Hideo 
Published: January 2013

AbstractSwern oxidation of various benzylic and secondary alcohols proceeds with two new ion‐supported methyl sulfoxides HSO and DSO in the presence of oxalyl chloride and triethylamine to give the corresponding aldehydes and ketones after simple work up.