bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐resolution climate projection dataset over India using dynamical downscaling
Authors: Barik Anasuya , Sahoo Sanjeeb Kumar , Kumari Sarita , Baidya Roy Somnath 
Published: July 2024

AbstractHigh‐resolution climate projections are valuable resources for understanding the regional impacts of climate change and developing appropriate adaptation/mitigation strategies. In this study, we developed a 10‐km gridded hydrometeorological dataset over India by dynamic downscaling of the bias‐corrected Community Earth System Model (CESMv1) climate projections under RCP8.5 scenario using the state‐of‐the‐art Weather Research and Forecasting (WRF) model. The downscaled CESM dataset (DSCESM) is archived in the World Data Center for Climate (WDCC) portal at three temporal resolutions (daily, monthly and monthly climatology) for current (2006–2015), mid‐century (2041–2050) and end‐century (2091–2100) periods. The dataset includes 2‐m air temperature, total accumulated precipitation, wind speed, relative humidity, sensible and latent heat fluxes, along with surface shortwave and outgoing longwave radiation. All the DSCESM variables were evaluated against reanalysis data and station observations for the period 2006–2015. This dataset can help us quantitatively understand regional climate change in India. It can also be used in conjunction with agricultural, hydrological, fire and other application models for climate change impact assessment on various sectors to help develop effective adaptation/mitigation strategies.
The effectiveness of health‐related quality of life (HRQOL) model in people with HIV: A cross sectional study
Authors: Abdollapour Mahsa , Seyed Alinaghi Seyed Ahmad , Kianimoghadam Amir Sam , Masjedi‐Arani Abbas , Bakhtiari Maryam , Manshadi Seyed Ali Dehghan , Rostami Mohsen , Mohraz Minoo 
Published: July 2024

AbstractBackground and AimsAcquired immune deficiency syndrome (AIDS) are a chronic and disabling disease that has a significant impact on quality of life due to weakening of physical health, financial problems and social stigma. This study aims to validate the Health‐related quality of life (HRQOL) model in people with human immunodeficiency viruses (HIV) in Iran.MethodsFour hundred and fifty‐two people with HIV from Imam Khomeini Hospital between the age of 18 and 65 years (men: 308, women: 144) participated in the research. anonymously completed a battery of questionnaires, namely the Persian basic psychological need satisfaction and frustration scale, SF‐36, PSQI and mindful attention awareness scale. The method of the present study was the structural equation model.ResultsCurrent findings indicated there is a significant positive between mindfulness and need satisfaction, physical and mental health and, significant negative between mindfulness and quality and quantity of sleep. Mindfulness and need satisfaction are significant positive predictors of quality of life in people with HIV. Quality and quantity of sleep are significant negative predictors of quality of life in people with HIV. There is a positive significance between need satisfaction and physical and mental health but there is a negative significance between need satisfaction and quality and quantity. there is a negative significant between the quality and quantity of sleep with physical and mental health. Mindfulness facilitates the satisfaction of more psychological needs and improves the quality of sleep. The quality of sleep is a negative significant predictor for physical and mental health but the quantity of sleep is a negative significant predictor for physical health.ConclusionThe HRQOL model can explain 18% of physical health and 16% of mental health in people with HIV in Iran. The elements of this model can be useful in evaluating and treating people with HIV in the Iranian Population. They also can use the models to plan for better services.
The risk of premature cardiac contractions (PAC/PVC) related to caffeine consumption among healthcare workers: A comprehensive review
Authors: Abdolmaleki Maryam , Ohadi Laya , Changizi Faraz , Seyed Sara , Farjam Mina 
Published: July 2024

AbstractBackground and AimsPremature atrial contractions (PACs) and premature ventricular contractions (PVCs) are ectopic heart rhythm disorders with implications for cardiovascular health. This study explores the relationship between caffeine consumption and the risk of PACs and PVCs, with a focus on healthcare workers, such as doctors, nurses, pharmacists, and midwives, who often rely on caffeine to combat fatigue, especially during night shifts.MethodsA thorough review was conducted through PubMed, Scopus, Google Scholar, and Web of Science, utilizing a combination of MeSH terms and keywords. Studies examining the link between caffeine consumption and PACs and PVCs, particularly in healthcare workers, were included.ResultsWe found that caffeine shows various effects based on dosage and can impact arrhythmia risk. Individuals working long shifts, including healthcare professionals, are prone to increased caffeine intake, leading to higher cardiovascular risk. To mitigate these risks, tailored guidelines for caffeine consumption, flexible shift scheduling, and mental health support services are recommended. Promoting caffeine alternatives within healthcare institutions can be beneficial.ConclusionAlthough caffeine may have potential benefits, its drawbacks, particularly concerning cardiovascular health, may surpass its advantages, especially when consumed in high doses. A multidisciplinary approach is crucial for healthcare workers’ well‐being and quality of patient care. Further research is required to refine and support these recommendations.
COVID‐19 infection during pregnancy and risk of early and late spontaneous miscarriages: A matched case–control population‐based study
Authors: Karawani Rawan , Barel Oshri , Lev‐Shalem Liat , Neeman Ortal , Pansky Moty , Brosh‐Nissimov Tal 
Published: July 2024

AbstractObjectivesTo evaluate the effect of COVID‐19 during the first trimester on the rate of first‐ and second‐trimester miscarriages. Secondary aims include the effect on stillbirths and the correlation between symptom severity and pregnancy outcomes.MethodsA retrospective matched case–control population‐based study extracted data from electronic medical records of a nationwide database of the second largest healthcare organization that provides medical services to over 2 000 000 patients in Israel. Pregnancy outcomes in COVID‐19‐positive pregnant patients in 2020 were compared with an age‐ and gestational‐week‐matched 1:2 case–control cohort of pre‐pandemic pregnant patients that received medical care in 2019.ResultsOf 68 485 pregnant women treated in 2020, 2333 were COVID‐19‐positive during pregnancy: 215 during the first trimester, 791 during the second trimester, and 1327 during the third trimester. We compared these data with the control cohort of 4580 pre‐pandemic pregnant patients. The rate of spontaneous miscarriage was significantly higher 146/2187 (6.3%) in COVID‐19‐positive patients versus 214/4580 (4.7%), (P < 0.01, odds ratio 1.34, 95% confidence interval 1.094–1.691). Most miscarriages occurred during the first trimester in both groups, yet the rates were significantly higher in the study group (5.4% vs 3.8%, P < 0.01). There was no association between COVID‐19 severity and miscarriage risk.ConclusionCOVID‐19 diagnosis during early pregnancy increased the rate of spontaneous miscarriage in our cohort compared with an age‐ and gestational‐week‐matched pre‐pandemic control group.
A case of spontaneous bladder rupture successfully conservatively treated with transurethral debridement and hyperbaric oxygen therapy
Authors: Iijima Heisuke , Someya Rikuri , Tanaka Eriko , Yamazaki Mami , Yokoi Tomoya , Takahashi Takehiro , Ueda Masakatsu , Shiraishi Yusuke , Yoshimura Koji 
Published: July 2024

IntroductionSpontaneous bladder rupture is a potentially life‐threatening condition. Its treatment often requires invasive strategies, mainly surgical closure, or cystectomy. We present a case where we successfully treated bladder rupture employing a less invasive technique of transurethral debridement and hyperbaric oxygen therapy.Case presentationA woman in her 80s presenting with lower abdominal pain was suspected of vesicoenteric fistula. Subsequent investigations confirmed bladder rupture to the abdominal wall, which eventually developed into a vesicocutaneous fistula. To minimize the invasiveness of treatment, a combined strategy of transurethral debridement of the fistula, and hyperbaric oxygen therapy was taken, resulting in successful outcome.ConclusionOur approach was unique for its tolerability in comparison to conventional surgical approaches taken towards this condition.
Need for integration of genetic counselors in the Portuguese healthcare: Their added value from the medical geneticists perspective
Authors: Lungu Ruxanda , Guimarães Lídia , Costa Catarina , Paneque Milena 
Published: July 2024

AbstractGenetic counseling plays a crucial role in providing individuals and families with comprehensive information, support, and guidance regarding genetic conditions. This article explores the benefits of the integration of the genetic counselor (GC) professional in Portugal and based on evidence collected from two focus group comprising Portuguese medical geneticists. The findings highlight the agreement of medical geneticists on the relevancy of GCs' integration into national healthcare as well as the need for education and training programs to enhance the genetics literacy of other healthcare professionals and increase public awareness and support for genetic counseling services. By incorporating GCs and adopting some actions suggested by participants as part of a future national strategy, Portugal can improve access to personalized genetic services and empower individuals to make informed decisions about their genetic health.
Citrin deficiency—The East‐side story
Authors: Häberle Johannes 
Published: July 2024

AbstractCitrin deficiency (CD) is a complex metabolic condition due to defects in SLC25A13 encoding citrin, an aspartate/glutamate carrier located in the mitochondrial inner membrane. The condition was first described in Japan and other East Asian countries in patients who were thought to suffer from classical citrullinemia type 1, and was therefore classified as a urea cycle disorder. With an improved understanding of its molecular basis, it became apparent that a defect of citrin is primarily affecting the malate–aspartate shuttle with however multiple secondary effects on many central metabolic pathways including glycolysis, gluconeogenesis, de novo lipogenesis and ureagenesis. In the meantime, it became also clear that CD must be considered as a global disease with patients identified in many parts of the world and affected by SLC25A13 genotypes different from those known in East Asian populations. The present short review summarizes the (hi)story of this complex metabolic condition and tries to explain the relevance of including CD as a differential diagnosis in neonates and infants with cholestasis and in (not only adult) patients with hyperammonemia of unknown origin with subsequent impact on the emergency management.
Newborn screening for acid sphingomyelinase deficiency in Illinois: A single center's experience
Authors: Hickey Rachel E. , Baker Joshua 
Published: July 2024

AbstractAcid sphingomyelinase deficiency (ASMD) is a rare lysosomal storage disorder (LSD) caused by reduced activity of the acid sphingomyelinase (ASM) enzyme, which leads to progressive storage of sphingomyelin and related lipids in the body. ASMD is caused by biallelic variants in the SMPD1 gene, which encodes for the ASM enzyme. Current estimates of disease incidence range from 0.4 to 0.6 in 100 000 livebirths, although this is likely an underestimation of the true frequency of the disorder. While there is no cure for ASMD, comprehensive care guidelines and enzyme replacement therapy are available, making an early diagnosis crucial. Newborn screening (NBS) for ASMD is possible through measurement of ASM activity in dried blood spots and offers the opportunity for early diagnosis. In 2015, Illinois (IL) became the first to initiate statewide implementation of NBS for ASMD. This study describes the outcomes of screen‐positive patients referred to Ann & Robert H. Lurie Children's Hospital (Lurie). Ten infants were referred for diagnostic evaluation at Lurie, and all 10 infants were classified as confirmed ASMD or at risk for ASMD through a combination of molecular and biochemical testing. Disease incidence was calculated using data from this statewide implementation program and was ~0.79 in 100 000 livebirths. This study demonstrates successful implementation of NBS for ASMD in IL, with high screen specificity and a notable absence of false positive screens.
T2*‐Relaxometry MRI to Assess Third Trimester Placental and Fetal Brain Oxygenation and Placental Characteristics in Healthy Fetuses and Fetuses With Congenital Heart Disease
Authors: Cromb Daniel , Steinweg Johannes , Aviles Verdera Jordina , van Poppel Milou P.M. , Bonthrone Alexandra F. , Lloyd David F.A. , Pushparajah Kuberan , Simpson John , Razavi Reza , Rutherford Mary , Counsell Serena J. , Hutter Jana 
Published: July 2024

BackgroundCongenital heart disease (CHD) has been linked to impaired placental and fetal brain development. Assessing the placenta and fetal brain in parallel may help further our understanding of the relationship between development of these organs.Hypothesis1) Placental and fetal brain oxygenation are correlated, 2) oxygenation in these organs is reduced in CHD compared to healthy controls, and 3) placental structure is altered in CHD.Study TypeRetrospective case–control.PopulationFifty‐one human fetuses with CHD (32 male; median [IQR] gestational age [GA] = 32.0 [30.9–32.9] weeks) and 30 from uncomplicated pregnancies with normal birth outcomes (18 male; median [IQR] GA = 34.5 [31.9–36.7] weeks).Field Strength/Sequence1.5 T single‐shot multi‐echo‐gradient‐echo echo‐planar imaging.AssessmentMasking was performed using an automated nnUnet model. Mean brain and placental T2* and quantitative measures of placental texture, volume, and morphology were calculated.Statistical TestsSpearman's correlation coefficient for determining the association between brain and placental T2*, and between brain and placental characteristics with GA. P‐values for comparing brain T2*, placenta T2*, and placental characteristics between groups derived from ANOVA. Significance level P < 0.05.ResultsThere was a significant positive association between placental and fetal brain T2* (⍴ = 0.46). Placental and fetal brain T2* showed a significant negative correlation with GA (placental T2* ⍴ = −0.65; fetal brain T2* ⍴ = −0.32). Both placental and fetal brain T2* values were significantly reduced in CHD, after adjusting for GA (placental T2*: control = 97 [±24] msec, CHD = 83 [±23] msec; brain T2*: control = 218 [±26] msec, CHD = 202 [±25] msec). Placental texture and morphology were also significantly altered in CHD (Texture: control = 0.84 [0.83–0.87], CHD = 0.80 [0.78–0.84]; Morphology: control = 9.9 [±2.2], CHD = 10.8 [±2.0]). For all fetuses, there was a significant positive association between placental T2* and placental texture (⍴ = 0.46).ConclusionPlacental and fetal brain T2* values are associated in healthy fetuses and those with CHD. Placental and fetal brain oxygenation are reduced in CHD. Placental appearance is significantly altered in CHD and shows associations with placental oxygenation, suggesting altered placental development and function may be related.Evidence Level3Technical EfficacyStage 3
Remediation of cationic dye from wastewater using a new environmentally friendly adsorbent: A response surface methodology and artificial neural network modeling study
Authors: Telli Samiya , Ghodbane Houria , Laouissi Aissa , Zamouche Meriem , Kadmi Yassine 
Published: July 2024

AbstractIn the current report, both response surface methodology (RSM) and artificial neural network (ANN) were employed to develop an innovative way for removing crystal violet (CV) from aqueous media using Haloxylon salicornicum (HS) as a cost‐effective, eco‐friendly adsorbent. HS was characterized using scanning electron microscopy (SEM) and Fourier‐transform infrared (FTIR) spectroscopy. The effects of operational parameters such as adsorbent dosage, initial dye concentration, and pH on HS were studied using a central composite design (CCD). A comparative analysis of the model findings and experimental measurements revealed high correlation coefficients (R2ANN = 0.994, R2RSM = 0.971), indicating both models accurately predicted HS. The predictive performance of the ANN and RSM models was evaluated using metrics such as mean absolute deviation (MAD), mean absolute percentage error (MAPE), root mean square error (RMSE), mean square error (MSE), and the correlation coefficient (R2). The results indicate that the ANN model provides greater accuracy compared to the RSM model. The experimental data were analyzed using both linear and nonlinear forms of pseudo‐first and pseudo‐second order kinetic models (LPFO, NLPFO, LPSO, and NLPSO). Statistical error analysis was conducted to identify the best‐fitting kinetic or isotherm models for the adsorption data. The adsorption process of CV/HS was best described by NLPSO and LPSO. Additionally, the adsorption isotherms were analyzed using linear and nonlinear regression methods. The findings indicated that the linear Langmuir and Freundlich isotherms provided a more accurate fit compared to the nonlinear models, demonstrating greater effectiveness in accounting for the adsorption parameters. Thermodynamic investigations clearly demonstrate that the biosorption of CV is spontaneous and exothermic. This cost‐effective adsorbent is highly promising for treating textile wastewater.
Delivery of Interventions for Multiple Lifestyle Factors in Primary Healthcare Settings: A Narrative Review Addressing Strategies for Effective Implementation
Authors: Leese Callum J. , Al‐Zubaidi Hussain , Smith Blair H. 
Published: July 2024

ABSTRACTThe escalating burden of lifestyle‐related diseases stands as a critical global public health challenge, contributing substantially to the prevalence of chronic conditions and a large portion of premature mortality. Despite this, concise evidence‐based lifestyle interventions targeting physical inactivity, nutrition, alcohol and smoking continue to be underutilised. Although good evidence exists for addressing the four lifestyle‐related risk factors independently, rarely do these present in isolation. Evidence is lacking regarding how to integrate interventions targeting multiple risk factors. Consequently, this paper aims to provide an overview of the evidence for delivering multiple interventions in primary healthcare settings.Different lifestyle factors are inter‐related, with decisions around ordering of the delivery of multiple lifestyle interventions an important consideration. There is evidence supporting the effectiveness of addressing some lifestyle factors simultaneously (e.g., physical activity and nutrition), although smoking cessation may be delivered best in a sequential approach. While the World Health Organisation highlights four key lifestyle factors (nutrition, physical activity, alcohol and smoking), incorporating additional elements such as sleep, mental well‐being and social connectedness offers a holistic framework for promoting well‐being.Despite the presentation of multiple behaviour risk factors being commonplace in healthcare settings, the evidence (outlined in the paper) for how best to deliver interventions to address this is limited, with further research and subsequent clinical guidance required.In order to address the barriers to delivering lifestyle interventions in primary care, innovation will be required. The use of non‐medical personnel, social prescribers and health coaches has the potential to alleviate time constraints, whilst mounting evidence exists for group consultations for addressing lifestyle‐related non‐communicable diseases (NCDs). If the challenges to implementation can be addressed, and if healthcare systems can adapt for the promotion of healthy lifestyles, the impact of NCDs can be mitigated.
“Ascorbic Acid” or “Vitamin C?” When and how scientifically or commonly named ingredients enhance product evaluations
Authors: Tok Dickson , Chen Xi , Chang Chun‐Tuan , Chu Xing‐Yu (Marcos) 
Published: July 2024

AbstractThis research investigates how product evaluations are impacted by two strategies for presenting an ingredient: with its common name or with its scientific name. We find that using the scientific name of a major ingredient enhances product evaluations when the product is perceived as utilitarian, whereas using the common name for that ingredient has a positive impact on product evaluations when the product is perceived as hedonic. The above fit effects are mediated by the consumer's enhanced sense of “feeling right.” Furthermore, we find that using the scientific name for a harmful ingredient that has been removed is more likely to enhance product evaluations than referring to the removed ingredient by its common name. Our findings provide important insights that can help marketers choose the ingredient name that most effectively promotes their products.
p110CUX1 promotes acute myeloid leukemia progression via regulating pyridoxal phosphatase expression and activating PI3K/AKT/mTOR signaling pathway
Authors: Zhang Hongyan , Zhong Liang , Wang Meng , Wan Peng , Chu Xuan , Chen Shuyu , Zhou Ziwei , Shao Xin , Liu Beizhong 
Published: July 2024

AbstractAs an evolutionarily conserved transcription factor, Cut‐like homeobox 1 (CUX1) plays crucial roles in embryonic and nervous system development, cell differentiation, and DNA damage repair. One of its major isoforms, p110CUX1, exhibits stable DNA binding capabilities and contributes to the regulation of cell cycle progression, proliferation, migration, and invasion. While p110CUX1 has been implicated in the progression of various malignant tumors, its involvement in acute myeloid leukemia (AML) remains uncertain. This study aims to elucidate the role of p110CUX1 in AML. Our findings reveal heightened expression levels of both p110CUX1 and pyridoxal phosphatase (PDXP) in AML cell lines. Overexpression of p110CUX1 promotes AML cell proliferation while inhibiting apoptosis and differentiation, whereas knockdown of PDXP yields contrasting effects. Mechanistically, p110CUX1 appears to facilitate AML development by upregulating PDXP expression and activating the PI3K/AKT/mTOR signaling pathway. Animal experimental corroborate the pro‐AML effect of p110CUX1. These results provide experimental evidence supporting the involvement of the p110CUX1‐PDXP‐PI3K/AKT/mTOR axis in AML progression. Hence, targeting p110CUX1 may hold promise as a therapeutic strategy for AML.