bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in shoulder function and muscle strength following rehabilitation exercise program in male patients with forward shoulder posture undergoing rotator cuff repair
Authors: Cho MinSuk , Kim MyungKi , Shin MalSoon , Seo YongGon , Moon HyungHoon , Park YunJin , Min KyungBin , Park JiMyeong , Lee SangMin 
Published: August 2024

Abstract

Background Abnormal posture is known to affect the efficacy of exercise therapy for musculoskeletal diseases. However, no studies to date have examined the effect of exercise programs should take into account the posture of the upper body in patients with rotator cuff disease. This study aimed to assess how rotator cuff and corrective exercises impact shoulder function and muscle strength post-arthroscopic rotator cuff repair surgery, providing tailored rehabilitation programs for patients with forward posture.
Methods Ninety male patients who underwent arthroscopic rotator cuff repair participated in this study. The patients were randomly divided into three groups corrective exercise group (CEG, n = 29), rotator cuff exercise group (REG, n = 27), and control group (CG, n = 28). Each group was instructed to apply different exercise programs to correct posture and enhance rotator cuff strength. All patients were checked by the American Shoulder and Elbow Surgeons (ASES) score, Constant score and muscle power, and range of motion preoperatively and postoperatively at 6 months and 1 year.
Results American Shoulder and Elbow Surgeons shoulder function scores showed significant difference between the three groups (p < 0.01), indicating that the corrective exercise program was more beneficial than rotator cuff exercises (p < 0.01). A significant intergroup difference in mean Constant score was also noted (p < 0.05), while a statistically significant interaction between time and group was observed (p < 0.05).
Conclusions These results suggested that a corrective exercise program can improve shoulder muscle strength and function after rotator cuff repair in male patients with a forward shoulder posture.
Bridging the Gap: Understanding Access Barriers to Dental Services for Individuals Living with Multiple Sclerosis; a scoping review
Authors: javadi Seyed kian haji seyed , Nouri Aisan , Ghasemi Hadi 
Published: August 2024

Abstract

Background:Accessing dental care presents a significant challenge for individuals with multiple sclerosis (MS), influenced by the diverse array of symptoms associated with the disease.This study aimed to identify the obstacles faced by people with MS (PwMS) when accessing dental health services.Method:The Joanna Briggs Institute scoping review methodology was employed to explore Embase, PubMed, Scopus, Web of Science and Google Scholar without date restrictions. Barriers to dental services in MS patients were identified and subsequently analyzed through thematic analysis, using Braun & Clarke approach.Result:Out of 172 articles searched, only three met the inclusion criteria. Barriers extracted from these articles were categorized into 4 main themes and 8 subthemes as follows: intrapersonal (comprising lack of information, manifestation of MS and fear), interpersonal (covering interactions between dental staff and MS patients, systemic interactions and support needs), structural (addressing physical and transportation barriers) and financial.Conclusion:Patients with MS face significant barriers accessing dental services. Enhancing wheelchair accessibility, improving government financial support and upgrading public transportation can notably improve service accessibility. Additionally, educating dental staff and implementing specialized training can enhance their readiness to provide effective care for MS patients.
A novel disulfidptosis-related lncRNA prognostic risk model: predicts the prognosis, tumor microenvironment and drug sensitivity in esophageal squamous cell carcinoma
Authors: Jiang Lei , Wei Guangxia , Ye Chunlin , Xu Chuan , Tang Yongchao , Qi Yingcheng , Peng Xiaoyue 
Published: August 2024

Abstract

Background: Disulfidptosisis a newly discovered type of cell death that differs from apoptosis, necrosis, ferroptosis and other death modes and is closely related to the occurrence and progression of tumors. However, the predictive potential and biological characteristics of disulfidptosis-related lncRNAs (DRGs-lncRNAs) in esophageal squamous cell carcinoma (ESCC) are unclear.
Methods: RNA transcriptome data, clinical information and mutation data for ESCC patients were obtained from The Cancer Genome Atlas (TCGA) database. Pearson correlation and Cox regression analyses were used to identify the DRGs-lncRNAs associated with overall survival (OS). LASSO regression analysis was used to construct the prognostic model. A nomogram was created to predict the prognosis of patients with ESCC. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene set enrichment analysis (GSEA) were used to identify the signaling pathways associated with the model. TIMER, CIBERSORT, ESTIMATE and other methods were used to analyze immune infiltration, immune function, immune checkpoints and drug sensitivity. The tumor mutation burden (TMB) and its relationship with the risk score were analyzed using mutation data from the TCGA database. Real-time polymerase chain reaction (RT‒PCR) was used to detect the expression of DRGs-lncRNAs in ESCC cell lines.
Results: A total of 155 lncRNAs significantly associated with disulfidptosis were identified. Through univariate Cox regression analysis, LASSO regression analysis and multivariate Cox regression analysis, 9 lncRNAs with independent prognostic significance were selected, and a prognosismodel was established. Survival analysis with the prognostic model revealed that there were obvious differences in survival between the high- and low-risk groups. Further analysis revealed that the immune microenvironment, immune infiltration, immune function, immune checkpoints, and drug sensitivity significantly differed between the high-risk and low-risk groups. In addition, RT‒PCR analysis revealed differential expression of DRG lncRNAs between ESCC cell lines and esophageal epithelial cell lines.
Conclusions:We established a DRG-lncRNA prognostic model that can be used to predict the prognosis, tumor mutation burden, immune cell infiltration, and drug sensitivity of ECSS patients. The results of this study provide valuable insights into the understanding of ESCC and provide valuable assistance for the individualized treatment of ESCC patients.
Prospective Study on the Association Between 36 Human Blood Cell Traits and Pan-Cancer Outcomes: A Mendelian Randomization Analysis
Authors: Liang Jinghao , Zhou Xinyi , Lin Yijian , Yin Hongming , Liu Yuanqing , Xie Zixian , Lin Hongmiao , Wu Tongtong , Zhang Xinrong , Tan Zhaofeng , Cheng Ziqiu , Yin Weiqiang , Guo Zhihua , Chen Wenzhe 
Published: August 2024

Abstract

Background
Research on the link between hematological characteristics and cancer risk has gained significant attention. Traditional epidemiological and cell biology studies, have identified correlations between blood traits and cancer risks. These findings are important as they suggest potential risk factors and biological mechanisms. However, these studies often can't confirm causality, pointing to the need for further investigation to understand these relationships better.
Methods
Mendelian randomization (MR), utilizing single-nucleotide polymorphisms as instrumental variables, was employed to investigate hematological trait causal effects on cancer risk. Thirty-six hematological traits were analyzed, and their impact on 28 major cancer outcomes was assessed using data from the FinnGen cohort, with eight major cancer outcomes and 22 cancer subsets. Furthermore, 1,008 MR analyses were conducted, incorporating sensitivity analyses (weighted median, MR-Egger, and MR-PRESSO) to address potential pleiotropy and heterogeneity.
Results
The analysis (data from 173,480 individuals primarily of European descent) revealed significant results. An increase in eosinophil count was associated with a reduced risk of colorectal malignancies (OR 0.7702, 95% CI 0.6852, 0.8658; p = 1.22E-05). Similarly, an increase in total eosinophil and basophil count was linked to a decreased risk of colorectal malignancies (OR 0.7798, 95% CI 0.6904, 0.8808;p = 6.30E-05). Elevated hematocrit (HCT) levels were associated with a reduced risk of ovarian cancer (OR 0.5857, 95% CI 0.4443, 0.7721;p = 1.47E-04). No significant heterogeneity or horizontal pleiotropy was observed.
Conclusions
Our study highlights the complex and context-dependent roles of hematological characteristics in cancers.
Prediction Model for Survival of Younger Patients with Breast Cancer Using the Breast Cancer Public Staging Database
Authors: Kang Ha Ye Jin , Ko Minsam , Ryu Kwang Sun 
Published: August 2024

Abstract

Breast cancer (BC) is a prevalent disease that contributes significantly to female mortality worldwide, particularly among young women, who often present with aggressive tumor. Despite the need for accurate prognosis in this demographic, existing studies have focused on broader age groups and often rely on the SEER database, which has limitations in variable selection. Data from 3,401 patients with BC were obtained from the Breast Cancer Public Staging Database. Patients were categorized as younger (n = 1,574) and older (n = 1,827). We utilized various survival models—Random Survival Forest, Gradient Boosting Survival, Extra Survival Trees (EST), and two penalized Cox proportional hazards models, Lasso and ElasticNet—to analyze and compare BC mortality characteristics between the groups. Additionally, older patients exhibited a higher prevalence of comorbidities compared to younger patients. The EST model outperformed the other models in predicting mortality for both age groups. Tumor stage was the primary variable used to train the model for mortality prediction in both groups. COPD was a significant variable only in younger patients with BC. Other variables exhibited varying degrees of consistency in each group. These findings can help identify high-risk young female patients with BC who require aggressive treatment by predicting the risk of mortality.
Pain Outcomes of Outside the Cage Robotic Thoracic Surgery: A prospective matched-cohort study
Authors: Streit Arthur , Walsh Lyndon , Stasiak Florent , Vautrin Nicolas , Guerci Philippe , Seitlinger Joseph , Renaud Stéphane 
Published: August 2024

Abstract

Management of acute and chronic pain after thoracic surgery for pulmonary resection or thymectomy remains a challenge for both thoracic surgeons and anesthesiologists. Advances in minimally invasive robotic procedures have made subcostal Outside the Cage (OTC) resections possible, but the procedure’s pain benefits have not been previously measured. A single center cohort was consented to undergo robotic-assisted thoracoscopic surgery (RATS) with an OTC or Transthoracic (TT) approach. On every post-operative day (POD), patients were asked to complete the Visual Analogue Scale (VAS) of Pain, assigning a score of 0–10 with higher scores equaling higher pain intensity. Additionally, patients’ opioid consumption was recorded and classified using Morphine Equivalent Dose (MED). Descriptive statistics of demographics, Mann-Whitney, and Chi-squared tests were performed in a matched analysis. Altogether, 50 OTC patients and 50 TT patients were included. For each group, 1 pneumonectomy, 19 lobectomies, 10 segmentectomies, and 20 thymectomies were performed. Between groups, most were male (n = 54; p = 0.42) and there were no differences in American Society of Anesthesiologists scores (p = 0.51), or tobacco consumption (p = 0.45). Patients who received an OTC approach experienced significantly lower pain scores on POD-0 (p = 0.001), POD-1 (p < 0.001), and POD-2 (p < 0.001). POD-3 OTC VAS scores were not different from the TT group (p = 0.09). Similarly, MED was lower for the OTC group on POD-0 (p < 0.001), POD-1 (p = 0.03), and POD-3 (p = 0.03). The RATS-OTC approach results in a more rapid decrease in self-reported pain by the patient as well as significantly lower levels of MED.
Child-robot interactions in different body and emotions oriented tasks: comparison with a human partner
Authors: Araguas Alice , Chopin Adrien , Blanchard Arnaud , Derégnaucourt Sébastien , Guellai Bahia 
Published: August 2024

Abstract

The aim of the present study was to compare interactions of children aged between 3 and 6 years, with a NAO robot or an adult partner, in various body-focused tasks: comprehension and recognition of body parts labels, imitation of movements, and recognition of emotions in the postures of the agent. For each task, performances were appreciated through scores levels. We found no effect of the demonstrator type on our results: children of different ages responded similarly to the the human or the robot demonstrator. We found an effect of age, with the olderchildren having higher scores for the comprehension of body parts labels on the demonstrator’s body, the imitation of body parts sequences and the identification of emotional key postures. Results are discussed in light of the implications of the use of social robots such as the NAO one, in interactive and learning situations with typical children.
Housing and Displacement as Risk Factors for Negative Health Outcomes Among People Who Inject Drugs in Los Angeles, CA, and Denver, CO, USA
Authors: Goldshear Jesse Lloyd , Corsi Karen F. , Ceasar Rachel Carmen , Ganesh Siddhi S. , Simpson Kelsey A. , Kral Alex H. , Bluthenthal Ricky N. 
Published: August 2024

Abstract

Background
The United States is currently experiencing a housing and homelessness crisis. In response, many cities have adopted policies of displacement that move unhoused people from place to place. Recent research indicates that these policies may have negative health impacts on unhoused people who use drugs. We sought to examine health risks associated with government-enforced displacement among unhoused people who inject drugs (PWID).
Methods
We interviewed a community-recruited sample of opioid-using PWID in Los Angeles, CA and Denver, CO between April 2021 and November 2022 (N = 472) about their demographic/socioeconomic characteristics, drug use patterns, housing status, government-enforced displacement including items discarded during displacements, and health risks. We constructed binomial generalized linear regression to examine the risk ratio of non-fatal overdose, and syringe and cooker/cotton sharing between four groups of participants: housed, unhoused and not displaced, unhoused and relocated voluntarily, and unhoused and displaced in the last three months.
Results
In the last 3 months, 52% of participants were unhoused and displaced by the government. Among those who were displaced, median number of government-enforced displacements was 3 with 69% reporting loss of syringes, 56% loss of naloxone, and 22% loss of buprenorphine medicine. In multivariate models, risk ratios for unhoused and displaced participants were higher for nonfatal overdose and cooker/cotton sharing as compared to housed participants. Risk ratios for syringe sharing amongst unhoused participants did not differ significantly.
Conclusions
Unhoused and displaced PWID experience elevated health risks. Ending the use of government-enforced displacement of unhoused PWID is essential to reducing health risk in this population.
Can physical activity mitigate the effect of systemic inflammation on cognitive performance? Results from a large older community dwelling population in the Netherlands
Authors: Fink Anne , Reinke Constantin , Aretz Benjamin , Heneka Michael T. , Doblhammer Gabriele 
Published: August 2024

Abstract

Background
Elevated systemic inflammation has been linked to poorer cognitive outcomes. Vigorous physical activity is associated with improved cognitive performance. This study investigates whether physical activity moderates the relationship between systemic inflammation and cognition.
Methods
Using the first wo waves from the Dutch Lifelines cohort study (N = 24,661, 50+), cognitive performance was assessed using a composite score from the Cogstate Brief Battery, with higher scores indicating lower cognitive performance. As a biomarker of systemic inflammation (SI), we used leukocyte count within the normal range of 3 to 11x109 cells per liter in EDTA blood samples in waves 1 and 2. We differentiated between low SI (< 6.5x109 cells per liter) and increased SI ( > = 6.5x109 cells per liter) and distinguished between 4 groups: (1) Persons, who had low SI in both waves; (2) Persons, who had increased SI in wave 1, but low SI in wave 2; (3) Persons, who had low SI in wave 1, but increased SI in wave 2; and (4) Persons, who had increased SI in both waves. We performed linear regression models to examine the effect of inflammation and vigorous physical activity on cognition, adjusting for cognitive task accuracy, age, sex, physical activity, education, medical conditions, and smoking status associated with cognitive impairment. An interaction effect was used to analyze the potential moderation of physical activity.
Results
Individuals with high systemic inflammation (SI) levels in both waves exhibited significantly longer reaction times (b = 0.061 [0.001;0.121]) compared to those with low SI levels in both waves. Individuals who engage in vigorous physical activity had significantly faster reaction times (-0.152 [-0.198;-0.107]) compared to those who do not. The interaction term was insignificant meaning that all individuals benefit from vigorous physical activity in terms of their cognitive performance, regardless of their SI group.
Conclusions
Our findings suggest that elevated systemic inflammation is a risk factor for cognitive impairment in older adults, and that physical activity may mitigate this risk. Therefore, promoting physical activity among the aging population may be an effective strategy to prevent or delay cognitive decline and dementia by potentially preventing systemic inflammation.
Characterizing Hormone Secretion Patterns in PitNETs with Metabolomics: Implications for Understanding Tumor Biology
Authors: Köktaşoğlu Fatmanur , Demirel Metin , Ağaç Halime Dulun , Alim Mehtap , Sarıkaya Ufuk , Dağdeviren Öykü , Çavuşoğlu Merve , Akdur Kerime , Karacam Büşra , Bekiroğlu Somer , Selek Sahabettin , Hatiboğlu Mustafa Aziz 
Published: August 2024

Abstract

Background
Pituitary neuroendocrine tumors (PitNETs) are heterogeneous neoplasms originating from the pituitary gland. Metabolomics, a comprehensive analysis of small molecules, has emerged as a valuable tool for studying pituitary tumors. In the presen investigation, a metabolomic methodology was employed to facilitate a more comprehensive understanding of tumor pathogenesis.
Methods
Nuclear Magnetic Resonance (NMR) Spectroscopy was utilized to investigate the metabolic profiles of hypophyseal tissue samples obtained from 22 patients with PitNETs, who underwent excisional surgery and exhibited varying hormone secretion statuses.
Results
Using NMR analysis, we identified 10 metabolites with significant changes, including O-Phosphoethanolamine (PEA), myo-Inositol (I), choline, and several amino acids in tissue samples. In the non-functioning (NF) group, elevated levels of PEA, myo-I, Glycine, and Choline were observed, whereas Glutamate, Phenylalanine, Valine, Isoleucine, Tyrosine, and Methionine exhibited decreased levels in the same group. Phospholipid metabolism, inositol phosphate metabolism, and amino acid metabolism are proposed as potential mechanisms underlying the secretory characteristics of tumor tissue.
Conclusions
Functioning and nonfunctioning PitNETs display distinct metabolic characteristics. Elevated PEA levels observed in the nonfunctioning group might have inhibited hormone synthesis by suppressing mitochondrial activity, which could potentially contribute to the development of tumors. Further research is warranted to validate these findings and explore their potential clinical applications, such as biomarker discovery and therapeutic targeting
Radiological features of pancreatic desmoid-type fibromatosis: A case series and systematic review
Authors: Tanishima Tomoya , Kurokawa Ryo , Sone Miyuki , Nakai Yudai , Abe Osamu , Kusumoto Masahiko 
Published: August 2024

Abstract

Purpose
This retrospective study aimed to investigate the radiological features of pancreatic desmoid-type fibromatosis (PDF) and systematically review the previous publications and two new cases.
Methods
We searched PubMed, Cochrane Library, and Web of Science Core Collection and included 31 patients with pathologically proven PDFs with analyzable preoperative computed tomography (CT) and magnetic resonance imaging, including two patients from our institution and 29 patients from 28 publications. Two board-certified radiologists reviewed all images.
Results
The median age of the patients was 39 years, with a male dominance observed (male, 54.8% vs. female, 45.2%). Abdominal pain was the most frequent symptom, occurring in 58.1% of cases. Surgical resection was performed in all cases of PDFs, resulting in a recurrence rate of 8.3% (2/24). The tumors were most commonly located in the pancreatic tail (23/31, 74.2%). In terms of morphology, a "solid" shape was most prevalent (14/31, 45.2%), followed by a "solid and cystic" shape (9/31, 29.0%) and a "cystic" shape (8/31, 25.8%). Characteristic radiological features included heterogeneous enhancement of the solid portion of the tumors on CT scans (13/20, 65%), moderate-to-weak enhancement in the late phase on CT (16/17, 94.1%), and a presence of cystic components in the tumors (17/31, 54.8%). In 16.1% (5/31) of PDFs, the cystic component was pathologically confirmed to be a dilated pancreatic duct.
Conclusion
We summarized the clinical and imaging characteristics of PDF. Although the incidence may not be high, cystic components suggesting a dilated pancreatic duct within the tumor are unique imaging features in PDF.