bluuebunny/crossref_metadata_2025_split huggingface dataset:
Employee burnout in the tourism industry during a cultural shift: the role of change uncertainty, change information and meaning-making
Authors: Katsaros Kleanthis K. 
Published: August 2024

PurposeBased on the job demands-resources theory, the objective of the current research is to investigate the influence of contextual (i.e. change information), as well as, personal (i.e. meaning-making) change resources on the perceived change uncertainty (PCU) and employee burnout (i.e. emotional exhaustion, cynicism, professional efficacy) relationship.Design/methodology/approachThe paper examines (1) whether PCU is related to burnout, (2) the extent to which change information and meaning-making are directly associated with burnout and (3) whether change information and meaning-making moderate the relationship between PCU and employee burnout. The research data were collected (in three sequential phases) from 293 employees of a group of Luxury Hotels and Resorts located in Southern Greece that has undergone a major cultural change.FindingsThe research findings suggest that change information is related to exhaustion and cynicism, as well as, that meaning-making is directly related to all of the burnout components. Change information buffered the negative relationship between PCU and exhaustion and between PCU and cynicism. Meaning-making moderated the negative relationship between PCU and exhaustion.Practical implicationsThe results support that leaders and managers will benefit significantly if they realize how important is to ensure that these change resources (i.e. change information and meaning-making) are in place during organizational changes and constantly evaluate the factors that can increase their employees’ well-being.Originality/valueThe originality of this study lies in the finding that change information moderated the negative relationship between PCU and exhaustion, as well as, PCU and cynicism; and that meaning-making moderated the negative relationship between PCU and exhaustion. Further, the study refers to the Greek tourism industry (9th in the word in terms of international tourist arrivals) which plays a pivotal role to the Greek economy. Finally, the research findings contribute to the uncertainty reduction theory, as well as, other related notions.
The moderation effect of strategic alignment on the relationship between plant investment decisions and operational performance
Authors: Ehie Ike C. , Ferreira Luis Miguel D.F. 
Published: August 2024

PurposeGiven the sudden increase in plant investments across the manufacturing sector due to recent disruptions in the global supply chain caused by the COVID pandemic, the Ukraine/Russian war, ocean piracy incidents, and others, there is a need to strategically align the investments decisions with the overall business strategy. This study aims to establish whether strategic alignment enhances the effect of plant investments on operational performance.Design/methodology/approachUsing the fifth version of the Global Manufacturing Research Group (GMRG V) dataset, we employ a structural equation model (SEM) to establish the moderating role of strategic alignment in plant investments-operational performance relationships.FindingsThe results suggest that strategic alignment enhances the positive effect of plant investments on operational performance, especially in cost, delivery, flexibility, and innovation. However, we found partial support for the moderating role of strategic alignment on quality performance.Research limitations/implicationsAlthough the study was based on the GMRG global dataset and numerous papers have been published using the same dataset, the use of a convenience sample on a select group of companies may limit the generalizability of the results. With the increase in new plant investments in computer chip manufacturing, electronics, and electrical in recent years, the findings could help corporate executives maximize the benefits of their investment decisions. Companies should ensure that their plant investment decisions are strategically aligned with their overall business strategy to achieve optimal outcomes.Practical implicationsWith the increase in new plant investments in computer chip manufacturing, electronics, and electrical in recent years, the findings could help corporate executives maximize the benefits of their investment decisions. Companies should ensure that their plant investment decisions are strategically aligned with their overall business strategy to achieve optimal outcomes.Originality/valueThe study comprehensively demonstrates that the extent of improvement in operational performance depends on how closely plant investment decisions align with the overall company strategy. Manufacturers should align major investment decisions with competitive priorities driven by market requirements to enhance operational performance.
When creation becomes fixation: venture obsession and agentic relationships
Authors: Peat Daniel Michael , Perrmann-Graham Jaclyn 
Published: August 2024

PurposeThe purpose of this paper is to examine the role of entrepreneurial passion, specifically venture obsession, in agentic relationships within entrepreneurial contexts. It aims to develop a new conceptualization of the role of the venture in these relationships and explore the negative impacts that can arise from the obsessive passion for the venture. The paper contributes to the literature by shedding light on the complexities of agency outside of large for-profit firms, unpacking components of self-interest in the agentic relationship and challenging the assumption that entrepreneurial passion is always beneficial for both the entrepreneur and the venture.Design/methodology/approachThis paper employs theoretical framework development and conceptual mapping to explore the role of entrepreneurial passion, specifically venture obsession, in agentic relationships within entrepreneurial contexts. We conducted a comprehensive literature review and synthesis of existing research on agency theory, entrepreneurial passion and venture obsession. By integrating these insights, we developed a new conceptual framework that theorizes the negative impacts of venture obsession on agentic relationships and venture performance. This approach allows us to propose a nuanced model that highlights the complexities and potential maladaptive behaviors associated with obsessive passion in entrepreneurship.FindingsVenture obsession can have detrimental outcomes, such as escalation of commitment and ignoring external feedback, due to the intense focus on protecting the venture at all costs.Originality/valueThe study highlights the impact of venture obsession on agentic relationships, emphasizing the balance between autonomy, competence and relatedness that entrepreneurs strive to maintain for their well-being. While previous research has explored the role of entrepreneurial passion and its effects on venture performance, this study extends the understanding by delving into the darker side of passion when it transforms into obsessive agency. By emphasizing the importance of maintaining a healthy balance in agentic relationships and considering the psychological well-being of entrepreneurs, this study adds nuance and depth to the existing knowledge on the subject.
Integrating threat mapping and animal movement data to identify high‐risk areas for endangered mobile species
Authors: Curk T. , Melzheimer J. , Aschenborn O. , Amar A. , Kolberg H. , Garbett R. , Maude G. , Reading R. P. , Selebatso M. , Berzaghi F. , Hempson G. P. , Botha A. , Thomson R. L. , Tate G. , Spiegel O. , Santangeli A. 
Published: August 2024

AbstractGiven the current biodiversity crisis, understanding how animals move across a landscape dotted with different anthropogenic threats and the consequences of those threats for animals is paramount to devising evidence‐based conservation interventions. Vultures roam across large areas and are highly exposed to poisoning, which represents a particularly damaging form of wildlife crime. In this study, we introduce a framework for quantifying the exposure to threats and illustrate an example of poisoning risk as a threat in an endangered African vulture species, the Lappet‐faced Vulture (Torgos tracheliotos). We combined GPS tracking data of 19 individuals collected between 2012 and 2022 with food availability and spatial threat maps of both intentional (poachers directly targeting vultures) and unintentional (farmers aiming to kill carnivores, with vultures being secondarily affected) poisoning across most of Southern Africa. We identified poisoning hotspots in northern Botswana and south‐eastern Namibia. These areas were also associated with a high number of vulture mortalities, providing additional support for poisoning risk. Northern Botswana and areas at the border between Botswana and South Africa were characterized by high food availability, potentially amplifying the mortality rate by attracting vultures from surrounding areas. Our results offer valuable insights for regional vulture conservation, together with a methodological framework for quantifying and mapping the spatial exposure to threats for mobile species of conservation concern, enabling improved targeting of conservation actions.
Policy uncertainty and non‐performing loans in Greece
Authors: Papadamou Stephanos , Pitsilkas Konstantinos 
Published: August 2024

AbstractBased on the growing interest in understanding the impact of uncertainty on various aspects of the economy, this study investigates the long‐run relationship between economic policy uncertainty (EPU), its components, unemployment, capital adequacy, liquidity risk, and non‐performing loans (NPLs) in Greece. Our findings indicate several key results: (1) There exists a negative, long‐term co‐integrating relationship between EPU and its components with financial stability. (2) Unemployment and capital adequacy also exert long‐term negative effects on financial stability. (3) These results hold robustly even after decomposing the total NPL ratio into mortgage, consumer, and business NPLs. (4) Consumer NPLs exhibit the slowest adjustment to long‐run equilibrium among the NPL sub‐categories, with mortgages presenting the fastest rate of adjustment. The findings underscore important policy implications: initiatives aimed at reducing fiscal and banking policy uncertainties and fostering a stable environment for businesses and households could effectively manage NPLs more efficiently, as uncertainty influences NPLs not only in the short run but also in the long run.
Chapter 6. Found field: Encountering a ridged garden bed archaeological site, Wing Reach, in Wisconsin, USA
Authors: McLeester Madeleine , Casana Jesse , Geraci Peter , Anastasio Alison 
Published: August 2024

AbstractRaised garden beds were once among the most common Native American earthworks in eastern North America. Typically located on prime agricultural land, they are now among the rarest. However, previously unrecorded archaeological raised beds can still be uncovered, especially in more marginal agricultural settings. This chapter details the discovery of a previously unrecorded ancestral Native American ridged agricultural field site in Juneau County, Wisconsin, USA. The site was first identified in 2020 by the authors using publicly available historical aerial imagery and a recent lidar survey. Here we describe its confirmation as a ridged field archaeological site and emplace it within broader anthropogenic landscapes of Wisconsin. Methods described herein can be employed globally to locate and document raised bed agriculture.
Domestic and family violence and associated maternal and perinatal outcomes: A population‐based retrospective cohort study
Authors: Baird Kathleen Marion , Phipps Hala , Javid Nasrin , Stephen de Vries Bradley, 
Published: August 2024

AbstractBackgroundDomestic family violence (DFV) is a global health concern affecting one in three women worldwide. Women are vulnerable to DFV throughout their life; however, pregnancy introduces an increased risk of experiencing DFV for millions of women and birthing people.MethodsRoutinely collected data from two hospitals in one local health district in New South Wales, Australia, were examined to determine the prevalence of DFV from 2010 to 2019. Demographics and outcome factors were compared by a reported history of DFV. Multivariable logistic regression was used to assess for predictors of DFV and to assess DFV as a predictor of adverse maternal and perinatal outcomes.ResultsOne percent of women (538/52,469) experienced DFV in the past year. Women experiencing domestic violence were more likely to be younger and have previous children, and had higher Edinburgh Depression Scores. These women were more likely to experience stillbirth (1.5% vs. 0.6%, p = 0.005). Maternal age < 25 years, cigarette smoking, alcohol use in pregnancy, mental health issues, and place of birth were associated with a recent history of DFV after adjusting for confounders. Recent DFV was associated with preterm birth and mental health issues but was not associated with admission to the neonatal nursery, small‐for‐gestational‐age birthweight, or caesarean section after adjusting for confounders.ConclusionThere was a relationship between DFV and poorer health outcomes for both women and their babies. This study highlighted that stillbirth is high among the population of women who experience DFV when compared to women who do not experience DFV.
The CALR mutations enhance the expression of the immunosuppressive proteins GARP and LAP on peripheral blood lymphocytes through increased binding of activated platelets
Authors: Holmström Morten Orebo , Ruders Josephine Hallundbæk , Riley Caroline Hasselbalch , Larsen Morten Kranker , Grauslund Jacob Handlos , Kjær Lasse , Skov Vibe , Ellervik Christina , Guo Belinda B. , Linden Matthew , Hasselbalch Hans Carl , Andersen Mads Hald 
Published: August 2024

SummaryRecently, an antibody which inhibits the glycoprotein A repetitions predominant (GARP)‐mediated release of active transforming growth factor beta (TGFβ) from the TGFβ propeptide latency‐associated peptide (LAP) showed preclinical activity in a murine model of the chronic myeloproliferative neoplasms (MPN). Consequently, we investigated the expression of the immunosuppressive molecules LAP and GARP on peripheral blood lymphocytes from 56 MPN patients and 11 healthy donors (HD). We found that lymphocytes from patients with MPN express higher levels of LAP and GARP with no strong differences found between the different MPN diagnoses. The impact of clinical parameters on the expression of LAP and GARP by lymphocytes showed that patients with calreticulin (CALR)mut MPN have increased expression compared with HD and patients with the Januskinase2 (JAK2) mutation. The fraction of lymphocytes bound to activated platelets (aPLT) strongly correlate to LAP and GARP expression suggesting that it is not the lymphocytes themselves but aPLT, which confer the increased expression of GARP and LAP on MPN patient lymphocytes. Notably, no differences in neither platelet counts nor anti‐thrombotic therapy was identified between patients with JAK2‐ and CALRmut patients. Analysis of platelet gene expression failed to identify differences in expression of relevant genes between JAK2‐ and CALRmut patients.
Biased receptor signalling and intracellular trafficking profiles of structurally distinct formylpeptide receptor 2 agonists
Authors: Peng Cheng , Vecchio Elizabeth A. , Nguyen Anh T. N. , De Seram Mia , Tang Ruby , Keov Peter , Woodman Owen L. , Chen Yung‐Chih , Baell Jonathan , May Lauren T. , Zhao Peishen , Ritchie Rebecca H. , Qin Cheng Xue 
Published: August 2024

BackgroundThere is increasing interest in developing FPR2 agonists (compound 43, ACT‐389949 and BMS‐986235) as potential pro‐resolving therapeutics, with ACT‐389949 and BMS‐986235 having entered phase I clinical development. FPR2 activation leads to diverse downstream outputs. ACT‐389949 was observed to cause rapid tachyphylaxis, while BMS‐986235 and compound 43 induced cardioprotective effects in preclinical models. We aim to characterise the differences in ligand‐receptor engagement and downstream signalling and trafficking bias profile.Experimental ApproachConcentration‐response curves to G protein dissociation, β‐arrestin recruitment, receptor trafficking and second messenger signalling were generated using FPR2 ligands (BMS‐986235, ACT‐389949, compound 43 and WKYMVm), in HEK293A cells. Log(τ/KA) was obtained from the operational model for bias analysis using WKYMVm as a reference ligand. Docking of FPR2 ligands into the active FPR2 cryoEM structure (PDBID: 7T6S) was performed using ICM pro software.Key ResultsBias analysis revealed that WKYMVm and ACT‐389949 shared a very similar bias profile. In comparison, BMS‐986235 and compound 43 displayed approximately 5‐ to 50‐fold bias away from β‐arrestin recruitment and trafficking pathways, while being 35‐ to 60‐fold biased towards cAMP inhibition and pERK1/2. Molecular docking predicted key amino acid interactions at the FPR2 shared between WKYMVm and ACT‐389949, but not with BMS‐986235 and compound 43.Conclusion and ImplicationsIn vitro characterisation demonstrated that WKYMVm and ACT‐389949 differ from BMS‐986235 and compound 43 in their signalling and protein coupling profile. This observation may be explained by differences in the ligand‐receptor interactions. In vitro characterisation provided significant insights into identifying the desired bias profile for FPR2‐based pharmacotherapy.
Design, Synthesis, and Biological Evaluation of Quinoline (Quinolinone) Derivatives as NADPH Oxidase (NOX) Inhibitors
Authors: Zhang Lei , Yang Xinliang , Yi Rui , Wu Siming , Li Qianbin , Hu Gaoyun , Chen Zhuo 
Published: August 2024

ABSTRACTNADPH oxidases (NOXs) are the sole enzyme in the human body that can directly produce reactive oxygen species. Recent studies have shown that NOXs is a very promising target for the treatment of diabetic nephropathy (DN). Here, a series of quinoline(quinolinone) derivatives have been designed based on pharmacophore strategy, synthesized and evaluated. Among them, 19d exhibits potent antiproliferative and NOXs inhibitory activities, and is worthy for further investigation.
Myelin endocytosis by brain endothelial cells causes endothelial iron overload and oligodendroglial iron hunger in hypoperfusion‐induced white matter injury
Authors: Liu Yuxin , Kang Xinmei , Lin Jiahao , Liu Yixin , Liu Sanxin , Li Chunyi , Deng Xiaohui , Huang Huipeng , Li Tiemei , Wang Shisi , Lu Danli , Jiang Yuxuan , Lu Zhengqi , Cai Wei , Lu Tingting 
Published: August 2024

AbstractAimsHypoperfusion induces significant white matter injury in cerebral vascular disorders, including arteriosclerotic cerebral small vessel disease (aCSVD), which is prevalent among the elderly. Iron transport by blood vessel endothelial cells (BVECs) from the periphery supports oligodendrocyte maturation and white matter repair. This study aims to elucidate the association between iron homeostasis changes and white matter injury severity, and explore the crosstalk between BVECs and oligodendroglial lineage cells.MethodsIn vivo: C57BL/6 mice were subjected to unilateral common carotid artery occlusion (UCCAO). In vitro: BVECs with myelin pretreatment were co‐cultured with oligodendrocyte progenitor cells (OPCs) or organotypic cerebellar slices subjected to oxygen and glucose deprivation.ResultsCirculatory iron tends to be stored in aCSVD patients with white matter injury. Myelin debris endocytosis by BVECs impairs iron transport, trapping iron in the blood and away from the brain, worsening oligodendrocyte iron deficiency in hypoperfusion‐induced white matter injury. Iron accumulation in BVECs triggers ferroptosis, suppressing iron transport and hindering white matter regeneration. Intranasal holo‐transferrin (hTF) administration bypassing the BBB alleviates oligodendrocyte iron deficiency and promotes myelin regeneration in hypoperfusion‐induced white matter injury.ConclusionThe iron imbalance between BVECs and oligodendroglial lineage cells is a potential therapeutic target in hypoperfusion‐induced white matter injury.
Exploring How Generating Metaphor Via Insight Versus Analysis Affects Metaphor Quality and Learning Outcomes
Authors: Yu Yuhua , Krebs Lindsay , Beeman Mark , Lai Vicky T. 
Published: August 2024

AbstractMetaphor generation is both a creative act and a means of learning. When learning a new concept, people often create a metaphor to connect the new concept to existing knowledge. Does the manner in which people generate a metaphor, via sudden insight (Aha! moment) or deliberate analysis, influence the quality of generation and subsequent learning outcomes? According to some research, deliberate processing enhances knowledge retention; hence, generation via analysis likely leads to better concept learning. However, other research has shown that solutions generated via insight are better remembered. In the current study, participants were presented with science concepts and descriptions, then generated metaphors for the concepts. They also indicated how they generated each metaphor and rated their metaphor for novelty and aptness. We assessed participants’ learning outcomes with a memory test and evaluated the creative quality of the metaphors based on self‐ and crowd‐sourced ratings. Consistent with the deliberate processing benefit, participants became more familiar with the target science concept if they previously generated a metaphor for the concept via analysis compared to via insight. We also found that metaphors generated via analysis did not differ from metaphors generated via insight in quality (aptness or novelty) nor in how well they were remembered. However, participants’ self‐evaluations of metaphors generated via insight showed more agreement with independent raters, suggesting the role of insight in modulating the creative ideation process. These preliminary findings have implications for understanding the nature of insight during idea generation and its impact on learning.
Dealing with the risk of fire in carbon sequestration strategies: Diverse forests or plantation monocultures?
Authors: Smith Warwick J. S. , Bekessy Sarah A. , Ward Michelle , Wintle Brendan A. 
Published: August 2024

AbstractClimate and land‐use change pose unprecedented threats to ecosystems, economies, and communities worldwide. To help mitigate the climate crisis, restoration is a rapidly growing industry used to offset carbon emissions. The most common approach is to plant fast‐growing monocultures with the aim of sequestering as much carbon as possible in the shortest time. However, there has been little economic analysis of planting options that explicitly address short and long‐term ecological risks such as fire, disease, and environmental change. Here we develop a method for quantifying ecological risks from fire to sequestration investments and show how these risks can be factored into an analysis of long‐term financial returns relative to opportunity costs. In the case study presented, we find that the apparent advantage of fast‐growing monoculture plantations is likely to be outweighed by the long‐term fire risks to the carbon stored in them. Our analytical framework provides a widely applicable approach to comparing planting options against each other and other land uses, considering key uncertainties. With climate change already manifesting through extreme weather events, rising sea levels, and shifting wildlife populations, our framework can be used to make informed decisions about the best solutions to increase carbon sequestration, reduce ecological risks, and reduce climate impacts with greater certainty.