bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gender differences in first-episode psychosis at 5-year follow-up – two different courses of disease? Results from the OPUS study at 5-year follow-up
Authors: Thorup A. , Albert N. , Bertelsen M. , Petersen L. , Jeppesen P. , Le Quack P. , Krarup G. , Jørgensen P. , Nordentoft M. 
Published: February 2013

AbstractObjectiveGender differences in psychosis have been investigated, and the results have contributed to a better understanding of the disease, but many questions are unanswered. In clinical terms, women and men with psychosis differ in terms of access to social support, tendency of substance abuse, level of functioning and symptom patterns. We aimed to investigate how gender differences at onset of psychosis develop during the first 5 years of treatment.MethodA total of 578 patients with a first-episode psychosis in the schizophrenia spectrum were included in the Danish OPUS trial – a randomized clinical trial comparing 2 years of intensive early-intervention programme with standard treatment. All patients were assessed with validated instruments at inclusion, and after 2 and 5 years. Data were analysed for significant gender differences.ResultsMales have significantly higher levels of negative symptoms at all times, and are more likely to live alone and suffer from substance abuse. Females reach higher levels of social functioning at follow-up, and show a greater tendency to be employed or in education than males. Markedly more women than men live with children. More women than men reach a state of recovery and are more compliant with medication.ConclusionThere are significant gender differences at 2- and 5-year follow-up in this large cohort of first-episode psychotic patients. Males and females show different symptomatology and different levels of social functioning.
Self-limiting and regenerative dynamics of perturbation growth on a vortex column
Authors: Hussain Fazle , Stout Eric 
Published: February 2013

AbstractWe study the mechanisms of centrifugal instability and its eventual self-limitation, as well as regenerative instability on a vortex column with a circulation overshoot (potentially unstable) via direct numerical simulations of the incompressible Navier–Stokes equations. The perturbation vorticity (${\boldsymbol{\omega} }^{\prime } $) dynamics are analysed in cylindrical ($r, \theta , z$) coordinates in the computationally accessible vortex Reynolds number, $\mathit{Re}({\equiv }\mathrm{circulation/viscosity} )$, range of 500–12 500, mostly for the axisymmetric mode (azimuthal wavenumber $m= 0$). Mean strain generates azimuthally oriented vorticity filaments (i.e. filaments with azimuthal vorticity, ${ \omega }_{\theta }^{\prime } $), producing positive Reynolds stress necessary for energy growth. This ${ \omega }_{\theta }^{\prime } $ in turn tilts negative mean axial vorticity, $- {\Omega }_{z} $ (associated with the overshoot), to amplify the filament, thus causing instability. (The initial energy growth rate (${\sigma }_{r} $), peak energy (${G}_{\mathit{max}} $) and time of peak energy (${T}_{p} $) are found to vary algebraically with $\mathit{Re}$.) Limitation of vorticity growth, also energy production, occurs as the filament moves the overshoot outward, hence lessening and shifting $\vert {- }{\Omega }_{z} \vert $, while also transporting the core $+ {\Omega }_{z} $, to the location of the filament. We discover that a basic change in overshoot decay behaviour from viscous to inviscid occurs at $Re\sim 5000$. We also find that the overshoot decay time has an asymptotic limit of 45 turnover times with increasing $\mathit{Re}$. After the limitation, the filament generates negative Reynolds stress, concomitant energy decay and hence self-limitation of growth; these inviscid effects are enhanced further by viscosity. In addition, the filament transports angular momentum radially inward, which can produce a new circulation overshoot and renewed instability. Energy decays at the $\mathit{Re}$ studied, but, at higher $\mathit{Re}$, regenerative growth of energy is likely due to the renewed mean shearing. New generation of overshoot and Reynolds stress is examined using a helical ($m= 1$) perturbation. Regenerative energy growth, possibly resulting in even vortex breakup, can be triggered by this new overshoot at practical $\mathit{Re}$ (${\sim }1{0}^{6} $ for trailing vortices), which are currently beyond the computational capability.
The role of large-scale vortical structures in transient convective heat transfer augmentation
Authors: Hubble David O. , Vlachos Pavlos P. , Diller Tom E. 
Published: February 2013

AbstractThe physical mechanism by which large-scale vortical structures augment convective heat transfer is a fundamental problem of turbulent flows. To investigate this phenomenon, two separate experiments were performed using simultaneous heat transfer and flow field measurements to study the vortex–wall interaction. Individual vortices were identified and studied both as part of a turbulent stagnation flow and as isolated vortex rings impacting on a surface. By examining the temporal evolution of both the flow field and the resulting heat transfer, it was observed that the surface thermal transport was governed by the transient interaction of the vortical structure with the wall. The magnitude of the heat transfer augmentation was dependent on the instantaneous strength, size and position of the vortex relative to the boundary layer. Based on these observations, an analytical model was developed from first principles that predicts the time-resolved surface convection using the transient properties of the vortical structure during its interaction with the wall. The analytical model was then applied, first to the simplified vortex ring model and then to the more complex stagnation region experiments. In both cases, the model was able to accurately predict the time-resolved convection resulting from the vortex interactions with the wall. These results reveal the central role of large-scale turbulent structures in the augmentation of thermal transport and establish a simple model for quantitative predictions of transient heat transfer.
Testing Potential New Sites for Optical Telescopes in Australia
Authors: Hotan C. E. , Tingay S. J. , Glazebrook K. 
Published: February 2013

AbstractIn coming years, Australia may find the need to build new optical telescopes to continue local programmes, contribute to global survey projects, and form a local multi-wavelength connection for the new radio telescopes being built. In this study, we refine possible locations for a new optical telescope by studying remotely sensed meteorological infrared data to ascertain expected cloud coverage rates across Australia, and combine these data with a digital elevation model using a geographic information system. We find that the best sites within Australia for building optical telescopes are likely to be on the highest mountains in the Hamersley Range in northwest Western Australia, while the MacDonnell Ranges in the Northern Territory may also be appropriate. We believe that similar seeing values to Siding Spring should be obtainable and with significantly more observing time at the identified sites. We expect to find twice as many clear nights as at current telescope sites. These sites are thus prime locations for future on-site testing.
The Murchison Widefield Array: The Square Kilometre Array Precursor at Low Radio Frequencies
Authors: Tingay S. J. , Goeke R. , Bowman J. D. , Emrich D. , Ord S. M. , Mitchell D. A. , Morales M. F. , Booler T. , Crosse B. , Wayth R. B. , Lonsdale C. J. , Tremblay S. , Pallot D. , Colegate T. , Wicenec A. , Kudryavtseva N. , Arcus W. , Barnes D. , Bernardi G. , Briggs F. , Burns S. , Bunton J. D. , Cappallo R. J. , Corey B. E. , Deshpande A. , Desouza L. , Gaensler B. M. , Greenhill L. J. , Hall P. J. , Hazelton B. J. , Herne D. , Hewitt J. N. , Johnston-Hollitt M. , Kaplan D. L. , Kasper J. C. , Kincaid B. B. , Koenig R. , Kratzenberg E. , Lynch M. J. , Mckinley B. , Mcwhirter S. R. , Morgan E. , Oberoi D. , Pathikulangara J. , Prabu T. , Remillard R. A. , Rogers A. E. E. , Roshi A. , Salah J. E. , Sault R. J. , Udaya-Shankar N. , Schlagenhaufer F. , Srivani K. S. , Stevens J. , Subrahmanyan R. , Waterson M. , Webster R. L. , Whitney A. R. , Williams A. , Williams C. L. , Wyithe J. S. B. 
Published: February 2013

AbstractThe Murchison Widefield Array (MWA) is one of three Square Kilometre Array Precursor telescopes and is located at the Murchison Radio-astronomy Observatory in the Murchison Shire of the mid-west of Western Australia, a location chosen for its extremely low levels of radio frequency interference. The MWA operates at low radio frequencies, 80–300 MHz, with a processed bandwidth of 30.72 MHz for both linear polarisations, and consists of 128 aperture arrays (known as tiles) distributed over a ~3-km diameter area. Novel hybrid hardware/software correlation and a real-time imaging and calibration systems comprise the MWA signal processing backend. In this paper, the as-built MWA is described both at a system and sub-system level, the expected performance of the array is presented, and the science goals of the instrument are summarised.
Influences of Galaxy Interactions on AGN Activity
Authors: Deng Xin-Fa , Yu Guisheng , Jiang Peng 
Published: February 2013

AbstractUsing two volume-limited Main galaxy samples of the Sloan Digital Sky Survey Data Release 7 , we explore influences of galaxy interactions on AGN activity. It is found that in the faint volume-limited sample, paired galaxies have a slightly higher AGN fraction than isolated galaxies, whereas in the luminous volume-limited sample, an opposite trend can be observed. The significance is <1σ. Thus, we do not observe strong evidence that interactions or mergers likely trigger the AGN activity.
The impact of a 16-week dietary intervention with prescribed amounts of whole-grain foods on subsequent, elective whole grain consumption
Authors: Brownlee Iain A. , Kuznesof Sharron A. , Moore Carmel , Jebb Susan A. , Seal Chris J. 
Published: February 2013

Previous (mainly population-based) studies have suggested the health benefits of the elective, lifelong inclusion of whole-grain foods in the diet, forming the basis for public health recommendations to increase whole grain consumption. Currently, there is limited evidence to assess how public health recommendations can best result in longer-term improvements in dietary intake. The present study aimed to assess the impact of a previous 16-week whole-grain intervention on subsequent, elective whole grain consumption in free-living individuals. Participants completed a postal FFQ 1, 6 and 12 months after the end of the whole-grain intervention study period. This FFQ included inputs for whole-grain foods commonly consumed in the UK. Whole grain consumption was significantly higher (approximately doubled) in participants who had received whole-grain foods during the intervention (P< 0·001) compared with the control group who did not receive whole-grain foods during the intervention. This increased whole grain consumption was lower than whole grain intake levels required by participants during the intervention period between 60 and 120 g whole grains/d. Aside from a significant increase (P< 0·001) in NSP consumption compared with control participants (mean increase 2–3 g/d), there were no obvious improvements to the pattern of foods of the intervention group. The results of the present study suggest that a period of direct exposure to whole-grain foods in non-habitual whole-grain food consumers may benefit subsequent, elective dietary patterns of whole grain consumption. These findings may therefore aid the development of future strategies to increase whole grain consumption for public health and/or food industry professionals.
The natural absence of RPA1N domain did not impair Leishmania amazonensis RPA-1 participation in DNA damage response and telomere protection
Authors: DA SILVEIRA RITA DE CÁSSIA VIVEIROS , DA SILVA MARCELO SANTOS , NUNES VINÍCIUS SANTANA , PEREZ ARINA MARINA , CANO MARIA ISABEL NOGUEIRA 
Published: February 2013

SUMMARYWe have previously shown that the subunit 1 of Leishmania amazonensis RPA (LaRPA-1) alone binds the G-rich telomeric strand and is structurally different from other RPA-1. It is analogous to telomere end-binding proteins described in model eukaryotes whose homologues were not identified in the protozoan´s genome. Here we show that LaRPA-1 is involved with damage response and telomere protection although it lacks the RPA1N domain involved with the binding with multiple checkpoint proteins. We induced DNA double-strand breaks (DSBs) in Leishmania using phleomycin. Damage was confirmed by TUNEL-positive nuclei and triggered a G1/S cell cycle arrest that was accompanied by nuclear accumulation of LaRPA-1 and RAD51 in the S phase of hydroxyurea-synchronized parasites. DSBs also increased the levels of RAD51 in non-synchronized parasites and of LaRPA-1 and RAD51 in the S phase of synchronized cells. More LaRPA-1 appeared immunoprecipitating telomeres in vivo and associated in a complex containing RAD51, although this interaction needs more investigation. RAD51 apparently co-localized with few telomeric clusters but it did not immunoprecipitate telomeric DNA. These findings suggest that LaRPA-1 and RAD51 work together in response to DNA DSBs and at telomeres, upon damage, LaRPA-1 works probably to prevent loss of single-stranded DNA and to assume a capping function.
A coordination-based CPG structure for 3D walking control
Authors: Huang Weiwei , Chew Chee-Meng , Hong Geok-Soon 
Published: February 2013

SUMMARYIn most of our daily motion tasks, the coordination between limbs is very crucial for successful execution of the tasks. In this paper, coordination among oscillators controlling in Cartesian space is studied to control bipedal walking. In our method, phase adjustment among oscillators is considered as one of the key issues to achieve coordination. A new phase adjustment method is proposed. With this method, an oscillator is able to coordinate other oscillators and maintain a desired phase relationship. This property is important for the walking control especially when external perturbations are given. To simplify the relationship between oscillators in a central pattern generator (CPG), a hierarchical CPG structure is adopted, where a main oscillator will be used to adjust other oscillators. In the simulation, the walking motion controlled by the CPG controller converges to a stable pattern even with external perturbations. We have implemented the controller in both the simulation model and real hardware robot.
On the automatic compilation of e-learning models to planning
Authors: Garrido Antonio , Fernández Susana , Morales Lluvia , Onaindía Eva , Borrajo Daniel , Castillo Luis 
Published: February 2013

AbstractThis paper presents a general approach to automatically compile e-learning models to planning, allowing us to easily generate plans, in the form of learning designs, by using existing domain-independent planners. The idea is to compile, first, a course defined in a standard e-learning language into a planning domain, and, second, a file containing students learning information into a planning problem. We provide a common compilation and extend it to three particular approaches that cover a full spectrum of planning paradigms, which increases the possibilities of using current planners: (i) hierarchical, (ii) including PDDL (Planning Domain Definition Language) actions with conditional effects and (iii) including PDDL durative actions. The learning designs are automatically generated from the plans and can be uploaded, and subsequently executed, by learning management platforms. We also provide an extensive analysis of the e-learning metadata specification required for planning, and the pros and cons on the knowledge engineering procedures used in each of the three compilations. Finally, we include some qualitative and quantitative experimentation of the compilations in several domain-independent planners to measure its scalability and applicability.
Past tense productivity in Dutch children with and without SLI: the role of morphophonology and frequency
Authors: RISPENS JUDITH E. , DE BREE ELISE H. 
Published: February 2013

ABSTRACTThis study focuses on morphophonology and frequency in past tense production. It was assessed whether Dutch five- and seven-year-old typically developing (TD) children and eight-year-old children with specific language impairment (SLI) produce the correct allomorph in regular, irregular, and novel past tense formation. Type frequency of the allomorph, token frequency and phonotactic probability (PP) of the novel verb form are considered. The results showed all groups were sensitive to the phonological cue. PP did not contribute to past tense inflection of novel verbs in any of the groups, but type frequency did in all three groups. Only the seven-year-old typically developing children relied on token frequency for inflection of regulars. The findings point to an important role of phonology and frequency in past tense acquisition for both TD children and children with SLI. We discuss how the SLI performance pattern relates to theories on SLI.
Effects of Stereotype Threat, Perceived Discrimination, and Examiner Race on Neuropsychological Performance: Simple as Black and White?
Authors: Thames April D. , Hinkin Charles H. , Byrd Desiree A. , Bilder Robert M. , Duff Kimberley J. , Mindt Monica Rivera , Arentoft Alyssa , Streiff Vanessa 
Published: February 2013

AbstractThe purpose of the current study was to examine the predictive roles of stereotype threat and perceived discrimination and the mediating role of examiner-examinee racial discordance on neuropsychological performance in a non-clinical sample of African American and Caucasian individuals. Ninety-two African American (n = 45) and Caucasian (n = 47) adults were randomly assigned to either a stereotype threat or non-threat condition. Within each condition, participants were randomly assigned to either a same race or different race examiner. All participants underwent neuropsychological testing and completed a measure of perceived discrimination. African Americans in the stereotype threat condition performed significantly worse on global NP (Mz = −.30, 95% confidence interval [CI] [−0.07, −0.67] than African Americans in the non-threat condition (Mz = 0.09, CI [0.15, 0.33]. African Americans who reported high levels of perceived discrimination performed significantly worse on memory tests when tested by an examiner of a different race, Mz = −1.19, 95% CI [−1.78, −.54], than African Americans who were tested by an examiner of the same race, Mz = 0.24, 95% CI [−0.24, 0.72]. The current study underscores the importance of considering the role of contextual variables in neuropsychological performance, as these variables may obscure the validity of results among certain racial/ethnic groups. (JINS, 2013, 19, 1–10)
Failure of the Hasse principle on general surfaces
Authors: Hassett Brendan , Várilly-Alvarado Anthony 
Published: February 2013

AbstractWe show that transcendental elements of the Brauer group of an algebraic surface can obstruct the Hasse principle. We construct a general $K 3$ surface $X$ of degree $2$ over $ \mathbb{Q} $, together with a 2-torsion Brauer class $\alpha $ that is unramified at every finite prime, but ramifies at real points of $X$. With motivation from Hodge theory, the pair $(X, \alpha )$ is constructed from a double cover of ${ \mathbb{P} }^{2} \times { \mathbb{P} }^{2} $ ramified over a hypersurface of bidegree $(2, 2)$.
Boundaries of instability zones for symplectic twist maps
Authors: Arnaud M.-C. 
Published: February 2013

AbstractVery few things are known about the curves that are at the boundary of the instability zones of symplectic twist maps. It is known that in general they have an irrational rotation number and that they cannot be KAM curves. We address the following questions. Can they be very smooth? Can they be non-${C}^{1} $?Can they have a Diophantine or a Liouville rotation number? We give a partial answer for${C}^{1} $and${C}^{2} $twist maps.In Theorem 1, we construct a${C}^{2} $symplectic twist map$f$of the annulus that has an essential invariant curve$\Gamma $such that$\bullet $ $\Gamma $is not differentiable;$\bullet $the dynamics of${f}_{\vert \Gamma } $is conjugated to the one of a Denjoy counter-example;$\bullet $ $\Gamma $is at the boundary of an instability zone for$f$.Using the Hayashi connecting lemma, we prove in Theroem 2 that any symplectic twist map restricted to an essential invariant curve can be embedded as the dynamics along a boundary of an instability zone for some${C}^{1} $symplectic twist map.
Intellectual Property Rights and the Conservation of Plant Biodiversity as a Common Concern of Humankind
Authors: Jaeckel Aline 
Published: February 2013

AbstractThis article makes the case for the obligation to conserve plant biodiversity to be classified as a common concern of humankind, to justify and indeed prescribe limitations on private intellectual property rights over plants and related processes. Within the biodiversity regime, the notion of ‘common concern of humankind’ subjects the permanent sovereignty of states over natural resources to the interests of humanity. It shifts the obligations of states from managing their own plant biodiversity towards conserving it on behalf of humankind. In contrast, TRIPS requires states to protect private intellectual property rights with little discretion to adequately balance them with public interests. This creates a dichotomy. This article argues that rather than mobilizing state sovereignty as rhetoric to distract from addressing common concerns of humankind, it should be constructed as a concept capable of facilitating these very concerns.
Transient overexpression of TGFBR3 induces apoptosis in human nasopharyngeal carcinoma CNE-2Z cells
Authors: Zheng Fangfang , He Kaiwen , Li Xin , Zhao Dan , Sun Fei , Zhang Yu , Nie Dan , Li Xingda , Chu Wenfeng , Sun Yan , Lu Yanjie 
Published: February 2013

NPC (nasopharyngeal carcinoma) is a common malignancy in southern China without defined aetiology. Recent studies have shown that TGFBR3 (transforming growth factor type III receptor, also known as betaglycan), exhibits anticancer activities. This study was to investigate the effects of TGFBR3 on NPC growth and the mechanisms for its actions. Effects of TGFBR3 overexpression on cell viability and apoptosis were measured by MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide], AO/EB (acridine orange/ethidium bromide) staining and electron microscopy in human NPC CNE-2Z cells. The expression of apoptosis-related proteins, p-Bad, Bad, XIAP (X-linked inhibitor of apoptosis), AIF (apoptosis-inducing factor), Bax and Bcl-2, was determined by Western blot or immunofluorescence analysis. Caspase 3 activity was measured by caspase 3 activity kit and [Ca2+]i (intracellular Ca2+ concentration) was detected by confocal microscopy. Transfection of TGFBR3 containing plasmid DNA at concentrations of 0.5 and 1 μg/ml reduced viability and induced apoptosis in CNE-2Z in concentration- and time-dependent manners. Forced expression of TGFBR3 up-regulated pro-apoptotic Bad and Bax protein, and down-regulated anti-apoptotic p-Bad, Bcl-2 and XIAP protein. Furthermore, transient overexpression of TGFBR3 also enhanced caspase 3 activity, increased [Ca2+]i and facilitated AIF redistribution from the mitochondria to the nucleus in CNE-2Z cells, which is independent of the caspase 3 pathway. These events were associated with TGFBR3-regulated multiple targets involved in CNE-2Z proliferation. Therefore transient overexpression of TGFBR3 may be a novel strategy for NPC prevention and therapy.