bluuebunny/crossref_metadata_2025_split huggingface dataset:
Héros malgré lui : le bureau de la signature du traité de Versailles
Authors: Khelil Claire Bonnotte 
Published: June 2024

Cet article se propose de revenir sur l’histoire insolite d’un bureau, à première vue banal, du XVIIIe siècle, conservé dans les collections du château de Versailles depuis 1914 : attribué à l’ébéniste Charles Cressent (1685-1768), ce meuble n’a pas d’existence connue avant 1863, date à laquelle il est envoyé au Palais de Compiègne. Après être passé au Mobilier national, puis au musée du Louvre, c’est à Versailles que son histoire prend une tournure inattendue : le 28 juin 1919, il devient le « bureau de la signature », lors de la cérémonie du traité de paix mettant fin à la Première Guerre mondiale. Dès lors, il sort de l’anonymat et accède à la notoriété dans les années 1920-1930, notamment à la faveur de cartes postales médiatisant l’événement. En dépôt sous étroite surveillance au château de Chambord de 1939 à 1945, en raison de l’intérêt que lui portent les autorités allemandes, il revient à la fin du conflit dans son giron versaillais. Exposé durant de nombreuses années dans le salon du Conseil, au sein du circuit des Grands Appartements, il est aujourd’hui présenté dans la nouvelle galerie d’histoire du château, inaugurée au mois de septembre 2023. Symbole de la Première Guerre mondiale, et désigné depuis 1919 par ce seul et unique prisme, ce meuble présente une trajectoire comparable à celle d’un acteur de cinéma : un parfait inconnu, propulsé quelques heures sous les feux de la rampe diplomatique, en tire une célébrité internationale, sensible encore 100 ans après les faits.
Jérôme Deyris, De la stabilité des prix à la stabilisation du climat ? L’économie politique du verdissement des banques centrales
Authors: Deyris Jérôme 
Published: June 2024

Ma thèse combine trois approches théoriques pour analyser l’essor du green central banking : l’économie politique des variétés de capitalismes, la socio-économie des organisations et de la bureaucratie, et la théorie évolutionniste du changement institutionnel. Je montre que si le contexte institutionnel dans lequel la banque centrale est encastrée détermine largement le type de verdissement poursuivi, les instruments déployés et les stratégies de légitimation adoptées, cette relation est moins stricte et moins unidirectionnelle qu’il n’y paraît. D’abord, le cadre institutionnel laisse des degrés de liberté importants aux banquiers centraux. Ces marges de manœuvre engendrent pour leur exploitation d’importantes luttes internes et la constitution de coalitions avec différents types d’acteurs externes aux intérêts divergents. Le résultat de ce rapport de force influence en retour la trajectoire d’évolution économique, en reconfigurant graduellement la place de la banque centrale dans la gouvernance de la finance.
National Athletic Trainers’ Association Position Statement: Emergency Action Plan Development and Implementation in Sport
Authors: Scarneo-Miller Samantha E. , Hosokawa Yuri , Drezner Jonathan A. , Hirschhorn Rebecca M. , Conway Darryl P. , Elkins Gregory A. , Hopper Michael N. , Strapp Edward J. 
Published: June 2024

ObjectiveAn emergency action plan (EAP) is a written document detailing the preparations and on-site emergency response of health care professionals and other stakeholders to medical emergencies in the prehospital setting. The EAP is developed to address any type of catastrophic injury response and should not be condition specific. The objective of this National Athletic Trainers’ Association position statement is to provide evidence-based and consensus-based recommendations for developing and implementing an EAP for sports settings.MethodsThese recommendations were developed by a multidisciplinary expert panel that performed (1) a comprehensive review of existing EAP evidence, (2) a modified Delphi process to define consensus recommendations, and (3) a strength of recommendation taxonomy determination for each recommendation.ResultsAn EAP is an essential tool designed to facilitate emergency preparedness and an efficient, coordinated emergency response during an athletic event. A comprehensive EAP should consider modes to optimize patient outcomes, the various stakeholders needed to develop the plan, the factors influencing effective implementation of the EAP, and the roles and responsibilities to ensure a structured response to a catastrophic injury.ConclusionsThese evidence-informed recommendations outline the necessary steps for emergency planning and provide considerations for the immediate management of patients with catastrophic injuries. Increasing knowledge and implementation of the EAP to manage patients with catastrophic injuries improves the overall response and decreases errors during an emergency.
Effectiveness of coma arousal therapy on patients with disorders of consciousness – A systematic review and meta-analysis
Authors: Kumar Sanjiv , Agarwal Nupur , Sanal Thankappan S 
Published: June 2024

Abstract:

BACKGROUND:
Disorders of consciousness (DOC) incorporate stages of awareness and arousal. Through coma arousal therapy sensory deprivation experienced by patients with DOC can be mitigated. Nevertheless, consensus concerning its effectiveness on these patients is still fractional.

PURPOSE:
This review aims to investigate the effectiveness of coma arousal therapies on patients with DOC.

METHODS:
A meta-analysis was performed by searching electronic databases using search terms, the studies investigating the effect of coma arousal therapy in patients with DOC using the Coma Recovery Scale-Revised and Glasgow Coma Scale as outcome measures were included. The risk of bias was assessed, using Cochrane and Joanna Briggs Institute critical appraisal tools. Further, analysis was conducted for the included studies.

RESULTS:
Out of 260 studies, 45 trials were reviewed and assessed for bias, with 31 studies included for analysis. The analysis demonstrates a significant difference in pre- and post - sensory stimulation, vagus nerve stimulation, transcranial magnetic stimulation, and transcranial direct current stimulation. Sensory stimulation showed the greatest mean difference of −4.96; 95% CI = -5.76 to - 4.15. The patients who underwent intervention after 3 months of illness showed significant improvement.

CONCLUSION:
The result shows that sensory stimulation, transcranial magnetic stimulation, and transcranial direct stimulation can improve behavioral outcomes of patients with DOC, wherein sensory stimulation is found to be more effective.
Blood–brain barrier disruption and edema formation due to prolonged starvation in wild-type mice
Authors: Hossain M. Ibrahim , Haque Mehjabeen , Akter Maria , Sharmin Sabrina , Ahmed Asif 
Published: June 2024

Abstract:

INTRODUCTION:
Different types of diseases have been treated by restricted caloric intake or fasting. Although during this long time, fasting protective measures, for example, supplements, are given to the patients to protect vital organs such as the liver and kidney, little attention is given to the brain. The current research aims to investigate hypoglycemia due to prolonged fasting disrupts blood–brain barrier (BBB) in mice.

MATERIALS AND METHODS:
Immunohistochemistry (IHC) and in situ hybridization (ISH) techniques were used to examine the expression of different genes. Evans blue extravasation and wet–dry technique were performed to evaluate the integrity of BBB and the formation of brain edema, respectively.

RESULTS:
We confirmed that hypoglycemia affected mice fasting brain by examining the increased expression of glucose transporter protein 1 and hyperphosphorylation of tau protein. We subsequently found downregulated expression of some genes, which are involved in maintaining BBB such as vascular endothelial growth factor (VEGF) in astrocytes and claudin-5 (a vital component of BBB) and VEGF receptor (VEGFR1) in endothelial cells by ISH. We also found that prolonged fasting caused the brain endothelial cells to express lipocalin-2, an inflammatory marker of brain endothelial cells. We performed Evans blue extravasation to show more dye was retained in the brain of fasted mice than in control mice as a result of BBB disruption. Finally, wet–dry method showed that the brain of prolonged fasted mice contained significantly higher amount of water confirming the formation of brain edema. Therefore, special attention should be given to the brain during treatment with prolonged fasting for various diseases.

CONCLUSIONS:
Our results demonstrated that hypoglycemia due to prolonged fasting disrupts BBB and produces brain edema in wild-type mice, highlighting the importance of brain health during treatment with prolonged fasting.
Safety and efficacy of tirofiban in preventing neurological deterioration in acute ischemic stroke (TREND): Protocol for an investigator-initiated, multicenter, prospective, randomized, open-label, masked endpoint trial
Authors: Wang Jing , Li Sijie , Li Chuanhui , Wu Chuanjie , Song Haiqing , Ma Qingfeng , Ji Xunming , Zhao Wenbo ,   for the TREND Investigators
Published: June 2024

Abstract:

INTRODUCTION:
Antithrombotic therapy prevents adverse ischemic events following acute ischemic stroke (AIS). Intravenous tirofiban provides desirable antiplatelet effects, especially in patients who are vulnerable to neurological deterioration (ND).

AIM:
The aim of the study was to test the hypothesis that intravenous administration of tirofiban, initiated within 24 h of ictus and continued for consecutive 72 h, would be more effective than aspirin in reducing the risk of ND within 72 h of enrollment among patients with potentially atherothrombotic ischemic stroke.

METHODS:
The Safety and Efficacy of Tirofiban in Preventing Neurological Deterioration in Acute Ischemic Stroke (TREND) trial is an investigator-initiated, multicenter, prospective, randomized, open-label, masked endpoint study. Its eligibility criteria included AIS secondary to potential atherosclerosis, a National Institutes of Health Stroke Scale (NIHSS) score ranging from 4 to 20 points, ineligibility for recanalization therapy, and administration within 24 h postsymptom onset. Randomization was performed at a 1:1 ratio to allocate 420 patients into two groups to receive an intravenous tirofiban bridge to oral antiplatelet drugs or direct oral antiplatelet drugs.

OUTCOMES:
The primary outcome is the proportion of patients with a ≥4-point increase in NIHSS score within 72 h of intervention compared to the score at enrollment. The key secondary outcomes include changes in NIHSS score, modified Rankin scale (mRS) score at 90 days, and dichotomized mRS scores (0–2 vs. 3–6 and 0–1 vs. 2–6) at 90 days. The safety variables are symptomatic intracerebral hemorrhage, any intracerebral hemorrhage, and systemic hemorrhage within 72 h after randomization and 90-day mortality.

CONCLUSIONS:
The TREND trial may identify the suitability of intravenous tirofiban as a routine clinical strategy to prevent ND in patients with AIS within 24 h of the onset of symptoms.

TRIAL REGISTRATION:

http://www.clinicaltrials.gov (identifier: NCT04491695).
Is the Spectrum of Bacterial Infection in Open Long-bone Fractures of the Lower Limb Changing?
Authors: Abel Livingston , Joseph Christina Marie , Ashok Anand , Ganesan Krupakaran , Samuel Sumant , Veeraraghavan Balaji 
Published: June 2024

Introduction:
Recent literature suggests a significant risk of infection by Gram-negative bacilli (GNB) in open Grade III fractures. Our prospective study aimed to identify the rate of infection with multidrug-resistant GNB (MDR-GNB) in open Grade III fractures and also study its clinical outcome.

Materials and Methods:
A prospective cohort study was conducted from November 2015 to May 2017 on Gustilo and Anderson Grade III open long-bone fractures of the lower limb. Demographic data, injury details, time from injury to receiving antibiotics, and index procedure were noted. Length of hospital stay, number of additional surgeries, and occurrence of complications were also noted. In infected open fractures, bacteriology and resistance pattern of the isolated microorganism were noted. Clinical outcomes of all included study patients were measured at 9 months.

Results:
A total of 231 patients with 275 open fractures involving femur, tibia, or fibula were studied. There was clinical suspicion of infection in 84 patients (36.4%) with 99 fractures (36%). Culture was positive in 43 patients (51.2%). MDR-GNB infection was seen in 19 patients representing 8.2% of all included study patients. Patients with MDR-GNB infection required a significantly higher percentage of additional surgical procedures than patients with non-MDR-GNB infection (2.2% vs. 0.8%, P < 0.0001) and had a lower return to work status (5.3% vs. 30.7%, P = 0.03), suggesting MDR-GNB infections have a worse outcome.

Conclusion:
Our study showing a high rate of MDR-GNB infection in open fractures highlights the therapeutic challenges involved in treating this nosocomial problem. MDR-GNB infection in open fractures is a serious cause of morbidity and poor outcome.
Spatial Profiles in Triple-negative Breast Cancer: Unraveling the Tumor Microenvironment and Biomarkers for Immune Checkpoint Inhibitors
Authors: Wu Cheng-Han , Chiu Yu-Chiao 
Published: June 2024

Abstract

Objective:
Immune checkpoint inhibitors (ICIs) have become an important treatment option for cancer. However, the predictive power of current biomarkers is limited for treatment response, especially in triple-negative breast cancer (TNBC). Investigation of the tumor microenvironment (TME) may provide biological insights into the response to ICIs by uncovering the interactions among tumor and immune cells. Emerging technologies of spatial transcriptomics (ST) and proteomics allow clinical researchers to better understand the TME.

Data Sources and Study Selection:
We reviewed the results of articles published in the past 10 years worldwide.

Results:
Emerging spatial profiling technologies can be classified into image-based and sequencing-based methods, both of which preserve information on tissue architecture with gene expression and/or protein abundance profiles. Here, we reviewed articles studying TNBC using spatial profiling techniques. By integrating spatial profiles, recent studies showed the relevance of gene and protein expression profiles in the TME of different subgroups. These ST and proteomic characteristics were shown to be associated with patients’ survival.

Conclusion:
The application of spatial profiling techniques to cancer research has significantly advanced our understanding of breast cancer biology, particularly in the context of TNBC. We are confident that the technology has the potential to revolutionize the prediction of treatment outcomes in the near future. By elucidating the nuances within the TME, spatial profiling opens up new possibilities for personalized strategies for immunotherapy.
Successful Conversion Surgery after Ceritinib Monotherapy in a Patient with Advanced Inflammatory Myofibroblastic Tumor Harboring SQSTM1-ALK fusion
Authors: Wang Qi-An , Lee Chao-Wei , Wu Ren-Chin , Wu Chiao-En 
Published: June 2024

Abstract
Inflammatory myofibroblastic tumor (IMT) is an intermediate malignant neoplasm, and approximately 50% of patients are anaplastic lymphoma kinase positive (ALK+). Given this unique trait, ALK tyrosine kinase inhibitors (TKIs), initially developed for ALK+ nonsmall cell lung carcinoma, were expected to be effective. Subsequently, crizotinib, a first-generation ALK-TKI, was approved by the U. S. Food and Drug Administration, and other generations of ALK-TKIs have since been tested for their efficacy. In this study, we report a case of unresectable IMT who showed a partial response to ceritinib, a second-generation ALK-TKI, allowing conversion surgery to be performed. Furthermore, the patient was found to have a rare ALK translocation, sequestosome 1 (5)-ALK (20), detected by next-generation sequencing. In conclusion, this case presents real-world evidence to establish the role of ceritinib as a first-line treatment for ALK+ IMT, which can contribute to further studies on ALK+ IMT.
Second Primary Malignancy after Hematopoietic Stem Cell Transplantation: A Single Institute Experience
Authors: Tan Tran-Der , Chiou Lun-Wei 
Published: June 2024

Abstract

Background:
Hematopoietic stem cell transplantation (HCT) is a curative treatment for various hematologic malignancies and some benign hematologic diseases. However, in addition to chronic graft-versus-host disease, second primary malignancy is also a long-term adverse effect.

Materials and Methods:
We retrospectively collected long-term follow-up data of 380 patients who had undergone transplantation (autologous in 184 with 126 long-term survivors and allogeneic in 196 patients with 100 long-term survivors) between 2001 and 2021 and analyzed the incidence and types of second primary malignancy.

Results:
Twelve patients had second primary malignancy, including five with head-and-neck squamous cell carcinoma (SCC), three with myelodysplastic syndrome/acute myeloid leukemia (MDS/AML), one with acute lymphoblastic leukemia (ALL), one with esophageal SCC, one with breast cancer, and one with papillary thyroid cancer. Of eight patients who underwent allogeneic hematopoietic stem cell transplants, five had head and neck, one had esophageal, one had breast, and one had papillary thyroid cancer. Of four patients who underwent autologous transplants, three had MDS/AML, and one had ALL. The cumulative incidence of second malignancy was 6% at 10 years and 16% at 19 years, and the postautologous and postallogeneic transplant rates were 5% versus 7% at 10 years and 15% versus 17% at 19 years.

Conclusion:
The occurrence of a second malignancy after HCT is a crucial issue of concern, and an early diagnosis is essential for posttransplant patients.
Papules to Pseudovesicular Lesions over Chest: A Mirror to Breast Malignancy
Authors: Patel Jigna , Pariath Kira 
Published: June 2024

Abstract
Here, we present a case of carcinoma telangiectoides in an unknown case of breast carcinoma presenting as multiple discrete to confluent, raised, solid, erythematous to skin-colored papules to plaques approximately 0.5–2 cm in size over an erythematous base over the chest. On the basis of clinical, histopathological, and immunohistochemical findings, a diagnosis of carcinoma telangiectoides was made. Diagnosis is difficult due to varying clinical presentations, but histopathology aids in the diagnosis. Through the present case, dermatologists should become aware of the diverse manifestations of cutaneous involvement of breast cancer. Early detection of cutaneous involvement may provide a window of opportunity for timely diagnosis and treatment of the primary tumor and prevent spread.
Metabolic Comorbidities in Pediatric Psoriasis—A Comparative Cross-Sectional Study in South-Asian Children
Authors: Joseph Ranjana E. , Sathishkumar Dharshini , Gupta Ankan , Korula Sophy 
Published: June 2024

Abstract

Background:
There is only limited data on the association between psoriasis and metabolic comorbidities in South-Asian children.

Objective:
To examine metabolic comorbidities among South-Asian children with and without psoriasis.

Materials and Methods:
A hospital-based, comparative, cross-sectional study was conducted in children with and without psoriasis over 19 months. Anthropometric, clinical, and metabolic comorbidity details (including disease extent and severity scores, obesity, systemic hypertension, diabetes mellitus, lipid abnormalities, and metabolic syndrome) were obtained in both groups according to standard criteria.

Results:
Fifty-eight children with psoriasis (25 males/33 females, age 11.3 ± 3.0 years, range 4 to 17 years) and 62 children without psoriasis (37 males/25 females, age 11.0 ± 3.6 years, range 4 to 18 years) were recruited. The prevalence of obesity (31.0% versus 14.5%, P = 0.031, odds ratio 2.65) and metabolic syndrome (18.6% versus 4.6%, P = 0.044, odds ratio 4.68) were higher in children with psoriasis than without. The prevalence of other metabolic comorbidities (systemic hypertension, pre-diabetes, lipid abnormalities, elevated serum alanine aminotransferase, and non-alcoholic fatty liver disease) was not different between children with and without psoriasis and between obese and non-obese children with psoriasis. Among children with psoriasis, those with abdominal obesity had significantly lower disease severity and extent scores than those without.

Conclusion:
Psoriasis is associated with a significantly higher prevalence of obesity and close to significantly higher prevalence of metabolic syndrome in South-Asian children. Screening for metabolic comorbidities is essential even in non-obese children with psoriasis. Disease extent and severity are less in obese compared to non-obese South-Asian children with psoriasis.
Vaccination equity: Exploring immunization coverage for selected vaccines in urban Bengaluru’s elderly community
Authors: Sangeetha M. D. , Deepthi R. , Menon P. K. Sreenath , Veeresappa D K 
Published: June 2024

Abstract

Introduction:
Globally, the proportion of elderly individuals is steadily increasing, posing significant challenges for health-care systems. Vaccination plays a crucial role in preventing vaccine-preventable diseases and associated morbidity and mortality in the elderly. In India, there is no national immunization schedule dedicated to the elderly group. This study aimed to explore the vaccination coverage for selected vaccines, namely pneumococcal conjugate vaccine, Influenza, and coronavirus disease 2019 (COVID-19), among the elderly residing in urban Bengaluru.

Methods:
A cross-sectional study was conducted between January and March 2023. Data were collected from 132 elderly participants living in three wards of Rajajinagar, Bengaluru. A structured questionnaire was used to collect sociodemographic data, health conditions, and vaccination status. The data were analyzed using EPI data 3.1 Software, and the Chi-square test and Fisher’s exact test were used to assess the association of demographic variables with vaccine intake.

Results:
The results showed that vaccination uptake for influenza and pneumococcal vaccines was nil, while for COVID-19 vaccines, 4.5% of participants had not taken any dose, 6.8% had taken the first dose, 57.6% had taken the second dose, and 31.1% had taken the booster dose. Sociodemographic analysis revealed significant associations between vaccine uptake and variables such as age, socioeconomic status (below the poverty line card holder), and body mass index.

Conclusion:
The low uptake of vaccines in the elderly population highlights the need for specialized strategies and initiatives to increase vaccination coverage. The study recommends suitable measures to improve vaccination coverage among elderly, creating awareness among healthcare professionals and the general population, and enhancing vaccine accessibility and availability to promote healthy aging in India.