bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Connective Tissue Nevus Associated with Seborrheic Keratosis‐like Eruption, Atrophic Scar, Alopecia, and Microtia
Authors: Isoda Midori , Okuda Yuka 
Published: April 2015

AbstractWe report a 44‐year‐old Japanese man who had connective tissue nevus, seborrheic keratosis‐like eruptions, atrophic scars on his hands and feet, alopecia, and microtia. These concurrent abnormalities are distinct from previously described multiple malformation syndromes.
DNA‐Damaging Agents Induce the 72‐kD Heat Shock Protein in SV40 Transformed Normal Human Fibroblasts
Authors: Muramatsu Tsutomu , Ohno Haruhiko , Shirai Toshihiko , Takahashi Akihisa , Ohnishi Takeo 
Published: April 2015

AbstractIn order to elucidate the involvement of DNA damage in the induction of heat shock proteins (stress proteins), we examined the induction of 72‐kD heat shock protein (HSP72) in an SV40‐transformed human fibroblast cell line (WI38VA13) which was exposed to various DNA‐damaging agents, including 1‐(4‐amino‐2‐methyl‐5‐pyrimidinyl)methyl‐3‐(2‐chloroethyl)‐3‐nitrosourea hydrochloride, bleomycin hydrochloride, cis‐diaminedichloroplatinum (II), mitomycin C, methylmethane sulfonate, N‐methyl‐N'‐nitro‐N‐nitrosoguanidine, and 4‐nitroquinoline‐N‐oxide. Induction of HSP72 was detected by the indirect immunofluorescence method using a monoclonal antibody. All the DNA‐damaging agents used in this study induced HSP72 on human fibroblasts. This result indicates that DNA damage is one trigger for the induction of HSP72.
Serum Sex Hormone Levels in Adult Patients with Atopic Dermatitis
Authors: Ebata Toshiya , Itamura Ronko , Aizawa Hiroshi , Niimura Michihito 
Published: April 2015

AbstractSerum levels of sex hormones were measured in adult patients with atopic dermatitis (AD) and compared with those in sex‐ and age‐matched healthy controls. In 40 male patients with AD, serum levels of testosterone (T) (447 ± 96 vs 593 ± 149 ng/dl, P<0.001), free testosterone (FT) (14.6 ± 3.2 vs 20.0 ± 5.1 pg/ml, P<0.001) and estradiol (E2) (27.2 ± 7.2 vs 33.2 ± 7.9 pg/ml, P<0.05) were significantly lower and serum levels of luteinizing hormone (LH) (4.57 ± 1.6 vs 3.11 ± 1.2 mIU/ml, P<0.001) were significantly higher than those in healthy controls. There were no significant differences in serum levels of dihydrotestosterone (DHT), dehydroepiandrosterone sulfate (DHEA‐S), dehydroepiandrosterone (DHEA), or follicle stimulating hormone (FSH) between the two groups. In 25 female patients with atopic dermatitis, T, FT, DHT and DHEA‐S levels did not differ from controls. In conclusion, serum T levels were lower in male patients with AD. However, similar changes were not seen in female patients.
Multiple Dermatofibromas Accompanied by Eruptive Benign Keratoses in a Patient with Systemic Lupus Erythematosus
Authors: Kuniyuki Shuichi , Shindow Kiyo 
Published: April 2015

AbstractWe describe a 39‐year‐old woman with systemic lupus erythematosus who developed 20 dermatofibromas accompanied by more than 30 eruptive benign keratoses while she was receiving systemic corticosteroid therapy. We are not aware of a previous case of multiple dermatofibromas accompanying multiple eruptive keratoses. The autoimmune disease or altered immunity, or both, may have played a role in the pathogenesis of these conditions.
A Case of Chromomycosis with Tumor‐like Growth
Authors: Usuki Kazunari , Yotsumoto Shin‐ichi , Hamada Hiroshi , Shimada Tokihiko , Fukumitsu Ken , Kanzaki Tamotsu 
Published: April 2015

AbstractA 66‐year‐old man who lived on Tokunoshima Island, a small and remote southern island of the Japanese archipelago, had suffered from chromomycosis for more than 30 years and presented with a tumor‐like growth on the posterior crural region of his right leg. Fonsecaea pedrosoi was identified as the pathogen from its growth pattern and micromorphological characteristics. The patient was successfully treated with 5‐fluorocytosine, itoraconazole, and topical thermotherapy.
Multiple Eccrine Hidrocystomas Associated with Graves' Disease
Authors: Nagai Yayoi , Ishikawa Osamu , Miyachi Yoshiki 
Published: April 2015

AbstractA 24‐year‐old woman presented with multiple translucent papules on the periorbital and malar areas. Histological examination demonstrated cystic structures lined with a few layers of flattened epithelial cells. These cells were positive for carcinoembryonic antigen, confirming the histological diagnosis of eccrine hidrocystoma. Physical examination revealed a goiter along with finger tremor and hyperhidrosis. The diagnosis of Graves' disease was established by endocrinological studies. The skin lesion as well as clinical symptoms disappeared as the thyroid function normalized with treatment. Graves' disease should be considered as one of the underlying diseases or conditions related to the development of the multiple eccrine hidrocystomas.
Familial Atypical Mole Syndrome Manifesting as Polypoid Melanoma: A Case Report and Review of the Japanese Literature
Authors: Misago Noriyuki , Kohda Hiromu 
Published: April 2015

AbstractA family with atypical mole syndrome which manifested as polypoid melanoma in one member is reported. A 46‐year‐old man presented with a polypoid tumor on his lower back, which was excised under clinical diagnosis of soft fibroma. The tumor proved to be polypoid melanoma. He was referred to our clinic, and examination revealed that he had the atypical mole syndrome phenotype. The clinicopathological screening of his first‐degree relatives confirmed that his 58‐year‐old sister had the same phenotype. In addition to our discussion of the clinical significance of polypoid melanoma, we also attempted to elucidate the characteristics of the reported Japanese cases of melanomas with atypical moles from a survey of the literature, which revealed the following characteristics: 1) younger mean age than that of total Japanese melanoma cases, 2) sun sensitive skin, 3) unexpectedly and frequently observed familial incidence (Kraemer's D1 and D2), 4) frequent site of the melanoma on the trunk and none on the sole of the foot, and 5) high incidence of superficial spreading melanoma and nodular melanoma, and 6) no cases of acral lentiginous melanoma.
Photoallergic Drug Eruption Due to Pyridoxine Hydrochloride
Authors: Tanaka Masaru , Niizeki Hironori , Shimizu Satoko , Miyakawa Shun‐ichi 
Published: April 2015

AbstractPhotoallergy to vitamin B6 is very rare; only a few cases of contact dermatitis and one case of photosensitive dermatitis due to pyritinol have been reported. We report here the first case of photoallergy drug eruption due to pyridoxine hydrochloride.A 71‐year‐old man developed papulo‐squamous erythemata which were confined to sun‐exposed sites. Photopatch testing, together with the clinical course, was helpful in reaching the initial diagnosis; this was confirmed by an oral challenge test.Photoallergic drug eruption due to vitamin B6 should be considered a rare cause of photosensitive dermatitis.
Atypical Melanosis of the Foot
Authors: Nogita Toshitatsu 
Published: April 2015

AbstractWe present a case of a seemingly malignant pigmented lesion on the foot, arising in a Japanese female. Clinically, the lesion was characterized by irregular borders and variegated pigmentation closely mimicking those of acral lentiginous melanoma in situ. However, the histologic findings revealed only focal, slight, melanocytic hyperplasia with minimal cytologic atypia along the basal layer. Despite the malignant clinical features, thorough histologic examination failed to disclose any area with significant melanocytic atypia or evidence of malignancy. To the best of our knowledge, no similar lesions with the clinical appearance of melanoma in situ and completely lacking histologic evidence of malignancy have been reported. We, therefore, prefer to designate this lesion as atypical melanosis of the foot, to highlight the clinically atypical findings and to distinguish this from malignant melanoma in situ of the foot (1).
Congenital Atrophic Plaque
Authors: Mihara Ichiro , Minesaki Yoshinori 
Published: April 2015

AbstractThe patient is a 13‐year‐old female who had had a patchy lesion on her back since birth which increased in size proportional to her age. When she visited our hospital at the age of 13, the lesion was a 30 times 43 mm, slightly depressed, well defined, irregularly shaped, atrophic plaque. Differential clinical diagnoses at that time included macular atrophy, congenital melanocytic nevus, and mastocytosis. Histopathologically, the lesion was characterized by patchy and scattered infiltrates of oval to spindle cells throughout the dermis extending into the subcutaneous fat tissue. Nerve fibers were found in each of the infiltrates. The tumor cells had oval nuclei with relatively abundant cytoplasm and were similar to nevus cells. They were negative for markers such as S‐100 protein, neuron specific enolase, epithelial membrane antigen, HMB‐45, Leu 7, Desmin, and α smooth muscle actin. However, the histopathological findings suggest that the lesion is a melanocytic or neurogenic tumor, possibly a congenital melanocytic nevus or a cellular neurothekoma, though a definite diagnosis could not be made.
The Effect of Methotrexate on the Expression of a Cysteine Protease Inhibitor (Type 2 Cystatin) in Rat Sebaceous Glands
Authors: Cohen Robert E. , Chien Hua‐Hong , Neiders Mirdza E. , Comeau Robin L. 
Published: April 2015

AbstractThe purpose of this study was to assess whether rat cystatin S, a cysteine proteinase inhibitor, is present in rat sebaceous glands, and to measure the effects of methotrexate on the expression of cystatin in these glands. With methotrexate treatment, the number of skin sebaceous cells expressing cystatin increased from 13.9% to 34.3% (P<.05). A smaller increase (from 15.3% to 23.9%; P=.1) was observed in Zymbal sebaceous glands. Type 2 cystatin could not be detected in the major salivary glands, nor in trachea, lung, stomach, small intestine, large intestine, spleen, liver, kidney, or pancreas, in any of the rats given either saline or methotrexate. Our results suggest that type 2 cystatin is a constituent of normal sebaceous glands, and that the amount of cystatin present in these glands increases with methotrexate administration. We speculate that, in addition to the protective functions ascribed to sebaceous lipids, sebum may augment the physical barrier of skin through secretion of cysteine proteinases that may be pharmacologically modulated.
Satisfactory Remission Achieved by PUVA Therapy in Langerhans Cell Hisiocytosis in an Elderly Patient
Authors: Sakai Hiroyuki , Ibe Masaki , Takahashi Hidetoshi , Matsuo Shinobu , Okamoto Kensaku , Makino Isao , Oomori Yukio , Iizuka Hajime 
Published: April 2015

AbstractLangerhans cell histiocytosis is currently regarded as a reactive proliferative process of Langerhans cells rather than a malignancy. The disease is characterized by Langerhans cell infiltration of skin, lung, bone and other organs. We report a 74‐year‐old man with Langerhans cell histiocytosis who had generalized hemorrhagic and crusted papules. He also had diabetes insipidus. Because he did not have any severe constitutional symptoms or failure of vital organs, we applied topical PUVA treatment to his skin lesions, which responded well to the therapy. Diabetes insipidus, however, remained, in spite of X ray radiotherapy for the pituiary lesion.
The Effect of a Collagenous Implant on Deep Dermo‐Periosteal Defects in the Rabbit
Authors: Osaki Ken‐ichi , Miura Akemi , Koide Mikio , Katakura Takeo , Sugihara Tsuneki 
Published: April 2015

AbstractIn plastic surgey, extensive wounds with exposed bone and loss of the periosteum (i.e., deep dermo‐periosteal defects) are difficult to treat, even with split‐thickness skin grafts, because such grafts rarely survive. Even when these grafts do survive, functional impairment often occurs subsequently. The application of a collagen sponge (Terudermis®, Terumo, Tokyo) to such wounds has previously been reported to accelerate granulation tissue formation, resulting in would healing and graft survival. However, this previous report only presented data relating to gross morphological appearanceIn this paper, we present histological evidence to demonstrate the beneficial effect of the collagen sponge on experimental dermo‐periosteal scalp defects in rabbits. About two weeks after the application of collagen sponge to the experimental wounds, a well‐vascularized granulation tissue was formed. Autologous split‐thickness skin grafts applied to this new granulation tissue were found to be viable one week after grafting.The results confirm histologically that collagen sponge is effective for the treatment of deep dermo‐periosteal defects which would not have regenerated skin cover with conventional therapies such as skin grafting or the temporary use of dermoprotective materials followed by skin grafting.
A Case of Lymphocutaneous Nocardiosis with a Review of Lymphocutaneous Nocardiosis Reported in Japan
Authors: Ye Zushou , Shimomura Hiroshi , Kudo Shoichiro , Arao Tatsuyoshi , Sato Yasuhiko , Ono Tomomichi 
Published: April 2015

AbstractAn 82‐year‐old Japanese male developed nodules and ulcers along the lymphatics after a fall in the garden of his house resulting in injuries to the dorsum of his left hand which lasted for 3 months. Nocardia brasiliensis was isolated from a nodule, supporting a diagnosis of the lymphocutaneous type of nocardiosis. He had previously developed generalized bone metastasis from prostatic cancer, and his resulting depressed immunity might have played a part in the nocardiosis genesis.Sixteen cases of the lymphocutaneous type of nocardiosis reported in Japan were reviewed.
Cutaneous Myiasis Due to Dermatobia hominis in Japan
Authors: Taniguchi Yoshiki , Yamazaki Satoshi , Ando Katsuhiko , Shimizu Masayuki 
Published: April 2015

AbstractA 29‐year‐old man with a furuncle‐like lesion brought in a maggot on the next day after his first visit to our clinic. He said it moved out from the eruption spontaneously. He had previously visited Parana and Sao Paulo in Brazil before he noticed the symptom. The maggot was confirmed to be a third instar larva of Dermatobia hominis. Japanese cases of cutaneous myiasis are reviewed.
Nicergorine‐induced Lichen Planus‐like Eruption
Authors: Hatano Yutaka , Murakami Isamu , Takayasu Susumu 
Published: April 2015

AbstractA case of a lichen planus‐like eruption due to nicergorine on the lower legs of an 84‐year‐old woman is reported. She presented with slightly pruritic, erythematous plaques of six months' duration. She had taken eight kinds of drugs, including nicregorine for cerebral arteriosclerosis, for two years. After nicergorine was discontinued, the eruption gradually disappeared. Readministration of nicergorine induced a similar eruption within two months. Histologic findings were identical in the two biopsy specimens obtained at the first visit and from the recurrent lesion. To our knowledge, this is the first report on nicergorine‐induced lichen planus‐like eruptions.
Immunohistochemical Detection of Ki‐67 in Epithelial Skin Tumors in Formalin‐fixed Paraffin‐embedded Tissue Sections Using a New Monoclonal Antibody (MIB‐1)
Authors: Matsuta Mayumi , Kimura Sadakatsu , Kosegawa Gen , Kon Saiichi , Matsuta Morimasa 
Published: April 2015

AbstractThe expression of the Ki‐67 antigen was investigated in 44 epithelial skin tumors using an immunohistochemical technique on formalin‐fixed, paraffin‐embedded tissue sections. Microwave oven heating was employed for retrieval of the antigen in these tissue sections.The staining patterns varied among the epithelial skin tumors. The assessment of immunohistochemical staining was based upon the growth fraction (GF), defined as the number of Ki‐67 positive cells divided by the total number of tumor cells counted and expressed as a percentage. GF was 9.7 ± 3.1% in seborrheic keratosis, 19.5 ± 2.9% in keratoacanthoma, 23.1 ± 4.9% in basal cell carcinoma, 18.5 ± 6.3% in actinic keratosis, 37.1 ± 6.0% in Bowen's disease, and 32.9 ± 10.5% in squamous cell carcinoma. There was a significant difference in GF between the keratoacanthoma and squamous cell carcinoma (p<0.01). Actinic keratosis showed a relatively low GF, whereas Bowen's disease showed a high one. Furthermore, the GF tended to increase with tumor cell differentiation in squamous cell carcinoma: 23.7% (±5.0) in well‐differentiated, 35.0% (±6.2) in moderately‐differentiated, and 47.6% (±4.5) in poorly‐differentiated squamous cell carcinomas. Immunohistochemistry with MIB‐1 may give useful additional information in the differential diagnosis of KA and SCC.
An Infrared Video Camera System to Observe Nocturnal Scratching in Atopic Dermatitis Patients
Authors: Ebata Toshiya , Aizawa Hiroshi , Kamide Ryoichi 
Published: April 2015

AbstractWe used an infrared video camera and video tape recorder system to record and analyze nocturnal scratching in seven patients with atopic dermatitis (AD) and three non‐itchy healthy controls. The patterns and the locations of scratching were successfully observed. Scratching bouts lasting more than 5 sec were counted/and the summation of the duration of all the scratching bouts (total scratching time, TST) was used as an index of nocturnal scratching. TST in patients with AD turned out to be some hundreds to ten thousands of seconds; the TST in controls was between zero and a hundred seconds. The infrared video camera system measured nocturnal scratching simply and reliably without disturbing the patients' sleep.
An Ultrastructural Study of the Retention Hyperkeratosis of Experimentally Induced Comedones in Rabbits: The Effects of Three Comedolytics
Authors: Oh Chee Won , Myung Ki Bum 
Published: April 2015

AbstractThe precise pathologic processes of comedo formation in acne are not well understool. Retention hyperkeratosis may play an important role. To evaluate the effects of three topical comedolytics, 20% azelaic acid, 0.1% tretinoin and 5% benzoyl peroxide, on the retention hyperkeratosis of experimentally induced comedones (EIC), an ultrastructural study was done. After formation of EIC with 50% oleic acid in paraffin oil on the external ears of rabbits, each comedolytic was applied for 4 weeks. Biopsies were taken every week and, using a Hitachi H‐600 transmission electron microscope, morphologic observations were done in the upper portion of the follicular epithelium. In EIC, after application of each comedolytic, the markedly thinned horny layer was loosely adhered by extremely few desmosomes and desmosomal bodies. The number and size of tonofilaments and keratohyaline granules decreased, but the number of variable sized Odland bodies increased in the upper epidermis. These findings appeared 1 week after application of either azelaic acid or benzoyl peroxide, and 3 weeks after application of tretinoin. For the first 2 weeks of tretinoin application, EIC showed rather compact hyperkeratosis with more desmosomes and desmosomal bodies than before. Azelaic acid tretinoin and benzoyl peroxide increased the number of Odland bodies, and the horny cells became less adhesive. This lysis of retention hyperkeratosis resulted in comedolysis. During 4 weeks of treatment with these three comedolytics, only tretinoin normalized the keratinization process.
Behçet's Disease as a Part of the Symptom Complex of SLE?
Authors: Lee Won Soo , Kim Soo Jung , Ahn Sung Ku 
Published: April 2015

AbstractSystemic lupus erythematosus and Behçet's disease are known to be induced by immunoregulatory defects and to have some identical manifestations. Although the possibility of the coexistence of these disorders exists only one example of an association of these disorders has been described previously by Lee et al. Therefore, we describe an example of typical SLE with additional symptoms of Behçet's disease as a part of the symptom complex of SLE.
Disseminated Cryptococcosis with Cutaneous Lesions
Authors: Mostafa Wedad Z. , Ishak Elia Anis , Ekladious Esmat M. , Arnaout Heba H. 
Published: April 2015

AbstractA case of disseminated cryptococcosis in an HIV‐negative patient presenting with cutaneous lesions is described for the first time in Egypt. The patient, a 16‐year‐old male, presented with cough, expectoration, loss of weight, and cutaneous lesions, mainly on the face and trunk. The lesions consisted of vegetating crusted plaques discharging purulent to sanguinous fluid and flattened, shiny, erythematous to brownish plaques. Anorexia, headache and personality changes soon followed. Histopathological examination of lesions was highly suggestive of a deep mycosis, particularly cryptococcosis. The fulminant disease advanced with central nervous system involvement. The progression was not arrested when systemic antifungal therapy was administered late in the disease course. Pathological examination of lungs, liver, pancreas and spleen revealed disseminated infection with no evidence of other underlying pathology.Disseminated cryptococcosis is a morbid infection, rare in an area where heightened awareness and raised index of suspicion will surely allow earlier diagnosis, management and better prognosis
Immunoglobulins and Their Receptors on Epidermal Langerhans Cells in Atopic Dermatitis
Authors: Okada Shigeru , Maeda Keisuke , Tanaka Yoichi , Anan Sadao , Yoshida Hikotaro 
Published: April 2015

AbstractTo elucidate the etiological role of immunoglobulin molecules on Langerhans cells (LCs) in atopic dermatitis, we conducted immunohistochemical studies on the localization of immunoglobulin G1 (IgG1), IgG2, IgG3, IgG4, IgA and IgM on epidermal LCs from 30 patients with atopic dermatitis (AD) and five non‐atopic healthy volunteers. We also investigated the types of receptors for the immunoglobulins (FcεRI, FcεRII, FcγRI, FcγRII, and FcγRIII) on epidermal LCs in the patients.IgE positive epidermal LCs were observed in 28 of 30 AD patients, and 46.7% of the epidermal LCs were positive for IgE. Both IgG1‐ and IgG2‐positive epidermal LCs were obserbed in 70% of AD patients, and 21.8% and 28.7% of the total epidermal LCs were positive for IgG1 and IgG2, respectively. IgG3‐ or IgG4‐positive LCs were present in only small proportions of AD patients. IgA‐positive LCs were observed in 8 AD patients; our study suggested that the IgA bound on LCs was secretory IgA (S‐IgA). These surface immunoglobulins were observed significantly more frequently on epidermal LCs in the involved skin of AD than in clinically uninvolved skin. No IgM‐positive epidermal LCs were observed in the AD patients or healthy volunteers. In non‐atopic healthy controls, no immunoglobulin‐binding LCs were observed. In receptors for immunoglobulins, FcεRI and FcγRII were exclusively expressed on nearly all epidermal LCs from all AD patients and all non‐atopic controls.These results suggested that not only IgE but also IgG and IgA may play some etiological role in the pathogenesis of AD.