bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting lymph node recurrence in cT1‐2N0 tongue squamous cell carcinoma: collaboration between artificial intelligence and pathologists
Authors: Adachi Masahiro , Taki Tetsuro , Kojima Motohiro , Sakamoto Naoya , Matsuura Kazuto , Hayashi Ryuichi , Tabuchi Keiji , Ishikawa Shumpei , Ishii Genichiro , Sakashita Shingo 
Published: August 2024

AbstractResearchers have attempted to identify the factors involved in lymph node recurrence in cT1‐2N0 tongue squamous cell carcinoma (SCC). However, studies combining histopathological and clinicopathological information in prediction models are limited. We aimed to develop a highly accurate lymph node recurrence prediction model for clinical stage T1‐2, N0 (cT1‐2N0) tongue SCC by integrating histopathological artificial intelligence (AI) with clinicopathological information. A dataset from 148 patients with cT1‐2N0 tongue SCC was divided into training and test sets. The prediction models were constructed using AI‐extracted information from whole slide images (WSIs), human‐assessed clinicopathological information, and both combined. Weakly supervised learning and machine learning algorithms were used for WSIs and clinicopathological information, respectively. The combination model utilised both algorithms. Highly predictive patches from the model were analysed for histopathological features. In the test set, the areas under the receiver operating characteristic (ROC) curve for the model using WSI, clinicopathological information, and both combined were 0.826, 0.835, and 0.991, respectively. The highest area under the ROC curve was achieved with the model combining WSI and clinicopathological factors. Histopathological feature analysis showed that highly predicted patches extracted from recurrence cases exhibited significantly more tumour cells, inflammatory cells, and muscle content compared with non‐recurrence cases. Moreover, patches with mixed inflammatory cells, tumour cells, and muscle were significantly more prevalent in recurrence versus non‐recurrence cases. The model integrating AI‐extracted histopathological and human‐assessed clinicopathological information demonstrated high accuracy in predicting lymph node recurrence in patients with cT1‐2N0 tongue SCC.
Hydrophilic Polymer Foam as a Monolithic Interfacial Solar Evaporator With Rapid Self‐Cleaning, High Evaporation Efficiency, and Salt Resistance
Authors: Wu Mingrui , Wei Yen , Zhu Yongqi , Bai Yuefeng , Wang Yuting , Wang Xiumei , Ho Shih‐Hsin , Wang Wei , Li Ruoxin 
Published: August 2024

AbstractManufacturing a multilayer evaporator with a delicate structure and removing salt accumulation during prolonged operation are challenges in seawater desalination. A flexible single‐layer salt‐rejecting monolithic porous evaporator (SRMPE) is presented that floats on the near surface of seawater without any support structure. The hydrophilic component of this network polymer modulates the water association state in SRMPE, achieving a high evaporation rate of 3.47 kg m−2 h−1 and an efficiency of 94.3%. With a large capillary water flux (14.4 L m−2 h−1), the SRMPE exhibits superior and rapid self‐cleaning by removing sodium chloride (NaCl) powder (33% by weight) within 1.25 h in simulated seawater (salinity, 3.5%) under 1 sun radiation. Furthermore, even after continuous irradiation for 12 h in highly concentrated brine (25% salinity), no salt crystallizes on the evaporator surface. It may stimulate creative work by scientists and engineers in the design of simple, highly efficient salt‐rejecting, self‐cleaning interfacial solar evaporators.
H2O2‐Activatable Liposomal Nanobomb Capable of Generating Hypoxia‐Irrelevant Alkyl Radicals by Photo‐Triggered Cascade Reaction for High‐Performance Elimination of Biofilm Bacteria
Authors: Yang Ke , Wang Li , Chen Jinyi , Wang Zefeng , Li Junqin , Chen Xi , Fu Shuting , Hai Luo , Deng Le , He Dinggeng 
Published: August 2024

AbstractHigh H2O2 levels are widely present at the infection sites or in the biofilm microenvironment. Herein, hemin with peroxidase‐like catalytic activity and its substrate, 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS), are simultaneously introduced into a liposomal nanoparticle containing thermosensitive 2,2′‐azobis[2‐(2‐imidazolin‐2‐yl) propane] dihydrochloride (AIBI)‐loaded bovine serum albumin (BAG), rationally constructing an H2O2‐activatable liposomal nanobomb (Lipo@BHA) for combating biofilm‐associated bacterial infections with high performance. In the presence of H2O2, hemin can catalyze the conversion of ABTS into its oxidized form (ABTS·+) with strong near‐infrared (NIR) absorption, which produces photonic hyperpyrexia to cause the decomposition of AIBI into oxygen‐independent alkyl radicals (·R) and nitrogen (N2) microbubbles. The former not only directly damage bacterial cells but also significantly accelerates the oxidization of ABTS to ABTS·+ for augmenting photothermal‐triggered generation of ·R. Interestingly, the released N2 can induce transient cavitation to rupture lysosomal nanoparticle and improve the biofilm permeability, thereby enhancing the antibiofilm effect of Lipo@BHA. The proposed Lipo@BHA exhibits satisfactory multi‐mode combination antibacterial properties. Through endogenous H2O2‐activated cascade reaction, Lipo@BHA achieves remarkable hypoxia‐irrelevant ·R therapy of biofilm‐associated wound infections with low cytotoxicity and good in vivo biosafety. Therefore, this work presents a versatile H2O2‐activatable cascade ·R generation strategy for biofilm‐specific therapeutic applications.
From Cell to Gene: Deciphering the Mechanism of Heart Failure With Single‐Cell Sequencing
Authors: Zhang Dan , Wen Qiang , Zhang Rui , Kou Kun , Lin Miao , Zhang Shiyu , Yang Jun , Shi Hangchuan , Yang Yan , Tan Xiaoqiu , Yin Shigang , Ou Xianhong 
Published: August 2024

AbstractHeart failure (HF) is a prevalent cardiovascular disease with significant morbidity and mortality rates worldwide. Due to the intricate structure of the heart, diverse cell types, and the complex pathogenesis of HF, further in‐depth investigation into the underlying mechanisms is required. The elucidation of the heterogeneity of cardiomyocytes and the intercellular communication network is particularly important. Traditional high‐throughput sequencing methods provide an average measure of gene expression, failing to capture the “heterogeneity” between cells and impacting the accuracy of gene function knowledge. In contrast, single‐cell sequencing techniques allow for the amplification of the entire genome or transcriptome at the individual cell level, facilitating the examination of gene structure and expression with unparalleled precision. This approach offers valuable insights into disease mechanisms, enabling the identification of changes in cellular components and gene expressions during hypertrophy associated with HF. Moreover, it reveals distinct cell populations and their unique roles in the HF microenvironment, providing a comprehensive understanding of the cellular landscape that underpins HF pathogenesis. This review focuses on the insights provided by single‐cell sequencing techniques into the mechanisms underlying HF and discusses the challenges encountered in current cardiovascular research.
Heterogeneous Structure of Ni–Mo Nanoalloys Decorated on MoOx for an Efficient Hydrogen Evolution Reaction Using Hydrogen Spillover
Authors: Song DongHoon , Roh Jeonghan , Choi Jungwoo , Lee Hyein , Koh Gyungmo , Kwon YongKeun , Kim HyoWon , Lee Hyuck Mo , Kim MinJoong , Cho EunAe 
Published: August 2024

AbstractHerein, a heterogeneous structure of Ni–Mo catalyst comprising Ni4Mo nanoalloys decorated on a MoOx matrix via electrodeposition is introduced. This catalyst exhibits remarkable hydrogen evolution reaction (HER) activity across a range of pH conditions. The heterogeneous Ni–Mo catalyst showed low overpotentials only of 24 and 86, 21 and 60, and 37 and 168 mV to produce a current density of 10 and 100 mA cm−2 (η10 and η100) in alkaline, acidic, and neutral media, respectively, which represents one of the most active catalysts for the HER. The enhanced activity is attributed to the hydrogen spillover effect, where hydrogen atoms migrate between the Ni4Mo alloys and the MoOx matrix, forming hydrogen molybdenum bronze as additional active sites. Additionally, the Ni4Mo facilitated the water dissociation process, which helps the Volmer step in the alkaline/neutral HER. Through electrochemical analysis, in situ Raman spectroscopy, and density functional theory calculations, the fast HER mechanism is elucidated.
The Hemagglutinin of Influenza A Virus Induces Ferroptosis to Facilitate Viral Replication
Authors: Ouyang Aotian , Chen Tong , Feng Yi , Zou Jiahui , Tu Shaoyu , Jiang Meijun , Sun Huimin , Zhou Hongbo 
Published: August 2024

AbstractFerroptosis is a novel form of cell death caused by the accumulation of lipid peroxides in an iron‐dependent manner. However, the precise mechanism underlying the exploitation of ferroptosis by influenza A viruses (IAV) remains unclear. The results demonstrate that IAV promotes its own replication through ferritinophagy by sensitizing cells to ferroptosis, with hemagglutinin identified as a key trigger in this process. Hemagglutinin interacts with autophagic receptors nuclear receptor coactivator 4 (NCOA4) and tax1‐binding protein 1 (TAX1BP1), facilitating the formation of ferritin‐NCOA4 condensates and inducing ferritinophagy. Further investigation shows that hemagglutinin‐induced ferritinophagy causes cellular lipid peroxidation, inhibits aggregation of mitochondrial antiviral signaling protein (MAVS), and suppresses the type I interferon response, thereby contributing to viral replication. Collectively, a novel mechanism by which IAV hemagglutinin induces ferritinophagy resulting in cellular lipid peroxidation, consequently impairing MAVS‐mediated antiviral immunity, is revealed.
Secondary Nucleation of Aβ Revealed by Single‐Molecule and Computational Approaches
Authors: Meyer Nathan , Arroyo Nicolas , Roustan Lois , Janot Jean‐Marc , Charles‐Achille Saly , Torrent Joan , Picaud Fabien , Balme Sébastien 
Published: August 2024

AbstractUnderstanding the mechanisms underlying amyloid‐β (Aβ) aggregation is pivotal in the context of Alzheimer's disease. This study aims to elucidate the secondary nucleation process of Aβ42 peptides by combining experimental and computational methods. Using a newly developed nanopipette‐based amyloid seeding and translocation assay, confocal fluorescence spectroscopy, and molecular dynamics simulations, the influence of the seed properties on Aβ aggregation is investigated. Both fragmented and unfragmented seeds played distinct roles in the formation of oligomers, with fragmented seeds facilitating the formation of larger aggregates early in the incubation phase. The results show that secondary nucleation leads to the formation of oligomers of various sizes and structures as well as larger fibrils structured in β‐sheets. From these findings a mechanism of secondary nucleation involving two types of aggregate populations, one released and one growing on the mother fiber is proposed.
Proton‐Coupled Electron Transfer on Cu2O/Ti3C2Tx MXene for Propane (C3H8) Synthesis from Electrochemical CO2 Reduction
Authors: Kim Jun Young , Hong Won Tae , Phu Thi Kim Cuong , Cho Seong Chan , Kim Byeongkyu , Baeck Unbeom , Oh Hyung‐Suk , Koh Jai Hyun , Yu Xu , Choi Chang Hyuck , Park Jongwook , Lee Sang Uck , Chung Chan‐Hwa , Kim Jung Kyu 
Published: August 2024

AbstractElectrochemical CO2 reduction reaction (CO2RR) to produce value‐added multi‐carbon chemicals has been an appealing approach to achieving environmentally friendly carbon neutrality in recent years. Despite extensive research focusing on the use of CO2 to produce high‐value chemicals like high‐energy‐density hydrocarbons, there have been few reports on the production of propane (C3H8), which requires carbon chain elongation and protonation. A rationally designed 0D/2D hybrid Cu2O anchored‐Ti3C2Tx MXene catalyst (Cu2O/MXene) is demonstrated with efficient CO2RR activity in an aqueous electrolyte to produce C3H8. As a result, a significantly high Faradaic efficiency (FE) of 3.3% is achieved for the synthesis of C3H8 via the CO2RR with Cu2O/MXene, which is ≈26 times higher than that of Cu/MXene prepared by the same hydrothermal process without NH4OH solution. Based on in‐situ attenuated total reflection‐Fourier transform infrared spectroscopy (ATR‐FTIR) and density functional theory (DFT) calculations, it is proposed that the significant electrocatalytic conversion originated from the synergistic behavior of the Cu2O nanoparticles, which bound the *C2 intermediates, and the MXene that bound the *CO coupling to the C3 intermediate. The results disclose that the rationally designed MXene‐based hybrid catalyst facilitates multi‐carbon coupling as well as protonation, thereby manipulating the CO2RR pathway.
Biodegradable Persistent Luminescence Nanoparticles as Pyroptosis Inducer for High‐Efficiency Tumor Immunotherapy
Authors: Liu Lin , Shi Junpeng , Wang Jinyuan , He Linping , Gao Yan , Lin Peng , Han Yutong , Ma Ping'an , Lin Jun , Zhang Yun 
Published: August 2024

AbstractPyroptosis possesses potent antitumor immune activity, making pyroptosis inducer development a promising direction for tumor immunotherapy. Persistent luminescence nanoparticles (PLNPs) are highly sensitive optical probes extensively employed in tumor diagnosis and therapy. However, a pyroptosis inducer based on PLNPs has not been reported yet. Herein, polyethylene glycol–poly lactic acid‐co‐glycolic acid (PEG–PLGA: PP) modified biodegradable CaS:Eu2+ (CSE@PP) PLNPs are synthesized as a pyroptosis inducer for tumor immunotherapy for the first time. The synthesized CSE@PP possesses biowindow persistent luminescence (PersL) and pH‐responsive degradation properties, allowing it to remain stable under neutral pH but degrade when exposed to weak acid (pH < 6.5). During degradation within the tumor, CSE@PP constantly releases H2S and Ca2+ while its PersL gradually fades away. Thus, the PersL signal can self‐monitor H2S and Ca2+ release. Furthermore, the released H2S and Ca2+ result in mitochondrial dysfunction and the inactivation of reactive oxygen species scavenging enzymes, synergistic facilitating intracellular oxidative stress, which induces caspase‐1/GSDM‐D dependent pyroptosis and subsequent antitumor immune responses. In a word, it is confirmed that CSE@PP can self‐monitor H2S and Ca2+ release and pyroptosis‐mediated tumor Immunotherapy. This work will facilitate biomedical applications of PLNPs and inspire pyroptosis‐induced tumor immunotherapy.
Engineering Shewanella oneidensis‐Carbon Felt Biohybrid Electrode Decorated with Bacterial Cellulose Aerogel‐Electropolymerized Anthraquinone to Boost Energy and Chemicals Production
Authors: Liu Qijing , Xu Wenliang , Ding Qinran , Zhang Yan , Zhang Junqi , Zhang Baocai , Yu Huan , Li Chao , Dai Longhai , Zhong Cheng , Lu Wenyu , Liu ZhanYing , Li Feng , Song Hao 
Published: August 2024

AbstractInterfacial electron transfer between electroactive microorganisms (EAMs) and electrodes underlies a wide range of bio‐electrochemical systems with diverse applications. However, the electron transfer rate at the biotic‐electrode interface remains low due to high transmembrane and cell‐electrode interfacial electron transfer resistance. Herein, a modular engineering strategy is adopted to construct a Shewanella oneidensis‐carbon felt biohybrid electrode decorated with bacterial cellulose aerogel‐electropolymerized anthraquinone to boost cell‐electrode interfacial electron transfer. First, a heterologous riboflavin synthesis and secretion pathway is constructed to increase flavin‐mediated transmembrane electron transfer. Second, outer membrane c‐Cyts OmcF is screened and optimized via protein engineering strategy to accelerate contacted‐based transmembrane electron transfer. Third, a S. oneidensis‐carbon felt biohybrid electrode decorated with bacterial cellulose aerogel and electropolymerized anthraquinone is constructed to boost the interfacial electron transfer. As a result, the internal resistance decreased to 42 Ω, 480.8‐fold lower than that of the wild‐type (WT) S. oneidensis MR‐1. The maximum power density reached 4286.6 ± 202.1 mW m−2, 72.8‐fold higher than that of WT. Lastly, the engineered biohybrid electrode exhibited superior abilities for bioelectricity harvest, Cr6+ reduction, and CO2 reduction. This study showed that enhancing transmembrane and cell‐electrode interfacial electron transfer is a promising way to increase the extracellular electron transfer of EAMs.
Molecular Design Motifs of Non‐Fullerene Acceptors for Mitigating All Inherent Non‐Ideal Energy Losses in Organic Photovoltaics
Authors: Kwon Hyun Min , Barma Sunil V. , Zuo Lijian , Lin Francis R. , Chueh Chu‐Chen , Jo Sae Byeok , Jen Alex K.‐Y. 
Published: August 2024

AbstractNon‐fullerene acceptors (NFAs) have demonstrated a great potential for the transcendence of performance limits in organic photovoltaics. Despite the tremendous efforts, however, synthetic control of non‐ideal recombination losses on the photovoltage are still elusive and thus lag far behind the inorganic counterparts. Here, a rational design strategy of non‐fullerene acceptors is presented to overcome the limitations derived from the inherent excited state properties of organic molecules. Spectroscopic studies on a series of chemical analogs of ladder‐type fused acceptors reveal that the radiative efficiency of non‐fullerene acceptors is predominantly determined by the inherently strong electron‐vibration coupling of their bound excited states, rather than the redistribution of molecular orbitals itself. In this sense, regardless of intramolecular charge transfer characteristics, the incorporation of rigid, and planar moiety with wide π plane is found to promote the dominance of long‐lived and weakly‐bound excited states in the photophysical process, in which the mitigated non‐radiative decays of NFAs can be directly translated into that of charge‐transfer states. Furthermore, the incorporation of such chemical moiety can minimize the evolution of subgap broadening in the bulk heterojunction blends, lowering the contribution of non‐ideal radiative losses. As a result, the model systems demonstrate the non‐radiative loss down to 180–190 meV, without sacrificing photocurrent generations, reaching that of inorganic counterparts.
Promoting the social in psychosocial recovery: Interviews with Australian National Disability Insurance Scheme participants
Authors: Roberts Joy , Stewart Victoria , Slattery Maddy 
Published: August 2024

AbstractSocial connection is a central element in mental health recovery and has been found to have a significant impact on the health and well‐being of individuals. This study examines the experiences of social connectedness for people accessing NDIS support for psychosocial disability. Interviews were conducted with eight NDIS participants. The study's findings suggest that people with psychosocial disabilities experience limited social connections and small social worlds. While NDIS support relationships were seen as important facilitators in increasing social engagement, these relationships may also limit opportunities for participants to extend their social connections beyond these professional support contacts. The impacts of participants' illnesses were identified as major barriers to establishing social connections and further research is needed to identify effective interventions that reduce social isolation in this population. This study highlights the role the NDIS can play in supporting social connection and inclusion for participants. Further consideration regarding the role of NDIS support relationships and NDIS‐funded interventions in supporting the social connectedness of participants is needed.
Modulating the Leverage Relationship in Nitrogen Fixation Through Hydrogen‐Bond‐Regulated Proton Transfer
Authors: Zhang Shaoce , Hong Hu , Zhang Rong , Wei Zhiquan , Wang Yiqiao , Chen Dong , Li Chuan , Li Pei , Cui Huilin , Hou Yue , Wang Shengnan , Ho Johnny C. , Guo Ying , Huang Zhaodong , Zhi Chunyi 
Published: August 2024

AbstractIn the electrochemical nitrogen reduction reaction (NRR), a leverage relationship exists between NH3‐producing activity and selectivity because of the competing hydrogen evolution reaction (HER), which means that high activity with strong protons adsorption causes low product selectivity. Herein, we design a novel metal‐organic hydrogen bonding framework (MOHBF) material to modulate this leverage relationship by a hydrogen‐bond‐regulated proton transfer pathway. The MOHBF material was composited with reduced graphene oxide (rGO) to form a Ni‐N2O2 molecular catalyst (Ni‐N2O2/rGO). The unique structure of O atoms in Ni‐O‐C and N‐O‐H could form hydrogen bonds with H2O molecules to interfere with protons being directly adsorbed onto Ni active sites, thus regulating the proton transfer mechanism and slowing the HER kinetics, thereby modulating the leverage relationship. Moreover, this catalyst has abundant Ni‐single‐atom sites enriched with Ni‐N/O coordination, conducive to the adsorption and activation of N2. The Ni‐N2O2/rGO exhibits simultaneously enhanced activity and selectivity of NH3 production with a maximum NH3 yield rate of 209.7 μg h−1 mgcat.−1 and a Faradaic efficiency of 45.7 %, outperforming other reported single‐atom NRR catalysts.
Organometallic Polymer Constructed by Active Fe−C12N8 Centers for Boosting Sodium‐Ion Storage
Authors: Wang Liang‐Yu , Ma Chao , Yang Jia‐Ning , Wang Kai‐Xue , Chen Jie‐Sheng 
Published: August 2024

AbstractOrganic‐metal coordination materials with rich structural diversity are considered as promising electrode materials for rechargeable sodium‐ion batteries. However, the electrochemical performance can be constrained by the limited number of active sites and structural instability under the discharge/charge process. Herein, organometallic polymer microspheres (Fe‐PDA‐220) with a unique d‐π conjugated structure was designed and successfully constructed through a simple synchronous polymerization and coordination reactions. Polymerization of phenylenediamine was initiated by Fe3+ and Fe2+ ions generated synchronously during the polymerization integrated with poly‐aminoquinone chains to form Fe−C12N8 active centers. Used as electrode materials for sodium‐ion batteries, the distinctive Fe−C bond significantly boosts the structural stability, and the π‐d conjugation system could facilitate electron transfer. A high reversible capacity of 345 mAh g−1 was delivered at 0.1 A g−1 and a capacity of 106 mAh g−1 was maintained even after discharged/charged at 1.0 A g−1 for 5000 cycles, outperforming most reported coordination materials. Spectroscopic and electronic analyses revealed that a two‐electron reaction occurred per active unit, accompanied by the reversible redox evolution of the C=N groups and Fe ions during the sodiation/desodiation. This work provides a promising and efficient strategy for boosting the electrochemical performance of organic electrode materials by the design of organometallic polymers.