bluuebunny/crossref_metadata_2025_split huggingface dataset:
COMPARISON OF NANOTECHNOLOGY ACCEPTANCE IN TURKEY AND SWITZERLAND
Authors: ÖNER M. ATILLA , KARACA FATIH , BEŞER SENEM GÖL , YILDIRMAZ HAKKI 
Published: May 2013

The aim of this paper is to replicate the study of Siegrist et al. [2007] and to present a comparison of nanotechnology acceptance in Turkey and Switzerland. The participants in our survey acknowledge the benefits of nanotechnology in achieving a preferred future (significance on the country's economy and on wealth creation, as well as quality of life) while reserving some sceptism on the institutions' responsibility in utilizing nanotechnology in the food domain. The most beneficial application in our study is viewed as nanotechnology-used bread compared to food packaging of Swiss study. The most risky application is seen as the application for tomatoes, the most affect is observed again for the tomatoes and willingness to buy(WTB) choice is more for juice application than any other applications analyzed in this study. Perceived benefits and perceived risks are found to have influence on the WTB nanotechnology applications in the food domain. Results did not support any evidence suggesting that the nanoinside applications are perceived as less acceptable than nanooutside application as stated in the Swiss study. Affect evoked by the information existing in environment about the nanotechnology products have significant relation with benefits and risks of this emerging technology. The relation between affect and risk in our model is positive whereas it is negative in Siegrist et al. [2007]. The effect of social trust on affect is found to be insignificant in our study which was an assumption of Siegrist et al. [2007] and found to be significant in their research. This paper attempts to help the managers to understand the youth and young adults' perception of nanotechnology in Turkey and to consider the importance of those perceptions for the realization of technological advances in improving their products and developing new ones.
Manganese-Enhanced MRI Reveals Early-Phase Radiation-Induced Cell Alterations In Vivo
Authors: Saito Shigeyoshi , Hasegawa Sumitaka , Sekita Aiko , Bakalova Rumiana , Furukawa Takako , Murase Kenya , Saga Tsuneo , Aoki Ichio 
Published: May 2013

Abstract
For tumor radiotherapy, the in vivo detection of early cellular responses is important for predicting therapeutic efficacy. Mn2+ is used as a positive contrast agent in manganese-enhanced MRI (MEMRI) and is expected to behave as a mimic of Ca2+ in many biologic systems. We conducted in vitro and in vivo MRI experiments with Mn2+ to investigate whether MEMRI can be used to detect cell alterations as an early-phase tumor response after radiotherapy. Colon-26 cells or a subcutaneously grafted colon-26 tumor model were irradiated with 20 Gy of X-rays. One day after irradiation, a significant augmentation of G2–M-phase cells, indicating a cell-cycle arrest, was observed in the irradiated cells in comparison with the control cells, although both early and late apoptotic alterations were rarely observed. The MEMRI signal in radiation-exposed tumor cells (R1: 0.77 ± 0.01 s−1) was significantly lower than that in control cells (R1: 0.82 ± 0.01 s−1) in vitro. MEMRI signal reduction was also observed in the in vivo tumor model 24 hours after irradiation (R1 of radiation: 0.97 ± 0.02 s−1, control: 1.10 ± 0.02 s−1), along with cell-cycle and proliferation alterations identified with immunostaining (cyclin D1 and Ki-67). Therefore, MEMRI after tumor radiotherapy was successfully used to detect cell alterations as an early-phase cellular response in vitro and in vivo. Cancer Res; 73(11); 3216–24. ©2013 AACR.
The ShcA PTB Domain Functions as a Biological Sensor of Phosphotyrosine Signaling during Breast Cancer Progression
Authors: Ahn Ryuhjin , Sabourin Valerie , Ha Jacqueline R. , Cory Sean , Maric Gordana , Im Young Kyuen , Hardy W. Rod , Zhao Hong , Park Morag , Hallett Michael , Siegel Peter M. , Pawson Tony , Ursini-Siegel Josie 
Published: May 2013

Abstract
ShcA (SHC1) is an adapter protein that possesses an SH2 and a PTB phosphotyrosine-binding motif. ShcA generally uses its PTB domain to engage activated receptor tyrosine kinases (RTK), but there has not been a definitive determination of the role of this domain in tumorigenesis. To address this question, we employed a ShcA mutant (R175Q) that no longer binds phosphotyrosine residues via its PTB domain. Here, we report that transgenic expression of this mutant delays onset of mammary tumors in the MMTV-PyMT mouse model of breast cancer. Paradoxically, we observed a robust increase in the growth and angiogenesis of mammary tumors expressing ShcR175Q, which displayed increased secretion of fibronectin and expression of integrin α5/β1, the principal fibronectin receptor. Sustained integrin engagement activated Src, which in turn phosphorylated proangiogenic RTKs, including platelet-derived growth factor receptor, fibroblast growth factor receptor, and Met, leading to increased VEGF secretion from ShcR175Q-expressing breast cancer cells. We defined a ShcR175Q-dependent gene signature that could stratify breast cancer patients with a high microvessel density. This study offers the first in vivo evidence of a critical role for intracellular signaling pathways downstream of the ShcA PTB domain, which both positively and negatively regulate tumorigenesis during various stages of breast cancer progression. Cancer Res; 73(14); 4521–32. ©2013 AACR.
Vesicle Trafficking and RNA Transfer Add Complexity and Connectivity to Cell–Cell Communication
Authors: Roberts Charles T. , Kurre Peter 
Published: May 2013

Abstract
Cell–cell communication, either in direct proximity or at a distance, generally occurs by receptor–ligand engagement and subsequent activation of downstream intracellular signaling cascades. This conventional, largely protein-based, model has long been considered necessary and sufficient to explain coordinate tissue and organismal function. Intriguing recent work indicates that many cells can also transfer RNA directly via cell–cell trafficking of nanometer-sized, lipid-bilayer vesicles. The distinct biogenesis pathways that give rise to the different vesicle types described to date are just beginning to be elucidated. Notwithstanding their diverse origin, all types of vesicles seem to contain a broad, cell-specific, nonrandom representation of cellular protein and RNA species. The cell–cell trafficking of coding and small noncoding RNAs in particular constitutes a new paradigm for the direct phenotypic modulation of cells in the local microenvironment and in distal organs. Here, we review the current understanding of RNA vesicle trafficking and its emerging role in cell–cell signaling. Cancer Res; 73(11); 3200–5. ©2013 AACR.
Mitoxantrone Targets Human Ubiquitin-Specific Peptidase 11 (USP11) and Is a Potent Inhibitor of Pancreatic Cancer Cell Survival
Authors: Burkhart Richard A. , Peng Yu , Norris Zoë A. , Tholey Renée M. , Talbott Vanessa A. , Liang Qin , Ai Yongxing , Miller Kathy , Lal Shruti , Cozzitorto Joseph A. , Witkiewicz Agnieska K. , Yeo Charles J. , Gehrmann Matthew , Napper Andrew , Winter Jordan M. , Sawicki Janet A. , Zhuang Zhihao , Brody Jonathan R. 
Published: May 2013

Abstract
Pancreatic ductal adenocarcinoma (PDA) is the fourth leading cause of cancer-related death in the United States, with a 95% five-year mortality rate. For over a decade, gemcitabine (GEM) has been the established first-line treatment for this disease despite suboptimal response rates. The development of PARP inhibitors that target the DNA damage repair (DDR) system in PDA cells has generated encouraging results. Ubiquitin-specific peptidase 11 (USP11), an enzyme that interacts with the DDR protein BRCA2, was recently discovered to play a key role in DNA double-strand break repair and may be a novel therapeutic target. A systematic high-throughput approach was used to biochemically screen 2,000 U.S. Food and Drug Administration (FDA)-approved compounds for inhibition of USP11 enzymatic activity. Six pharmacologically active small molecules that inhibit USP11 enzymatic activity were identified. An in vitro drug sensitivity assay demonstrated that one of these USP11 inhibitors, mitoxantrone, impacted PDA cell survival with an IC50 of less than 10 nM. Importantly, across six different PDA cell lines, two with defects in the Fanconi anemia/BRCA2 pathway (Hs766T and Capan-1), mitoxantrone is 40- to 20,000-fold more potent than GEM, with increased endogenous USP11 mRNA levels associated with increased sensitivity to mitoxantrone. Interestingly, USP11 silencing in PDA cells also enhanced sensitivity to GEM. These findings establish a preclinical model for the rapid discovery of FDA-approved compounds and identify USP11 as a target of mitoxantrone in PDA.
Implications: This high-throughput approach provides a strong rationale to study mitoxantrone in an early-phase clinical setting for the treatment of PDA. Mol Cancer Res; 11(8); 901–11. ©2013 AACR.
PD-L1 Expression in the Merkel Cell Carcinoma Microenvironment: Association with Inflammation, Merkel Cell Polyomavirus, and Overall Survival
Authors: Lipson Evan J. , Vincent Jeremy G. , Loyo Myriam , Kagohara Luciane T. , Luber Brandon S. , Wang Hao , Xu Haiying , Nayar Suresh K. , Wang Timothy S. , Sidransky David , Anders Robert A. , Topalian Suzanne L. , Taube Janis M. 
Published: May 2013

AbstractMerkel cell carcinoma (MCC) is a lethal, virus-associated cancer that lacks effective therapies for advanced disease. Agents blocking the PD-1/PD-L1 pathway have shown objective, durable tumor regressions in patients with advanced solid malignancies and efficacy has been linked to PD-L1 expression in the tumor microenvironment. To investigate whether MCC might be a target for PD-1/PD-L1 blockade, we examined MCC PD-L1 expression, its association with tumor-infiltrating lymphocytes (TIL), Merkel cell polyomavirus (MCPyV), and overall survival. Sixty-seven MCC specimens from 49 patients were assessed with immunohistochemistry for PD-L1 expression by tumor cells and TILs, and immune infiltrates were characterized phenotypically. Tumor cell and TIL PD-L1 expression were observed in 49% and 55% of patients, respectively. In specimens with PD-L1(+) tumor cells, 97% (28/29) showed a geographic association with immune infiltrates. Among specimens with moderate-severe TIL intensities, 100% (29/29) showed PD-L1 expression by tumor cells. Significant associations were also observed between the presence of MCPyV DNA, a brisk inflammatory response, and tumor cell PD-L1 expression: MCPyV(-) tumor cells were uniformly PD-L1(-). Taken together, these findings suggest that a local tumor-specific and potentially MCPyV-specific immune response drives tumor PD-L1 expression, similar to previous observations in melanoma and head and neck squamous cell carcinomas. In multivariate analyses, PD-L1(-) MCCs were independently associated with worse overall survival [HR 3.12; 95% confidence interval, 1.28–7.61; P = 0.012]. These findings suggest that an endogenous immune response promotes PD-L1 expression in the MCC microenvironment when MCPyV is present, and provide a rationale for investigating therapies blocking PD-1/PD-L1 for patients with MCC. Cancer Immunol Res; 1(1); 54–63. ©2013 AACR.
Multi-Institutional Study of Implantable Defibrillator Lead Performance in Children and Young Adults
Authors: Atallah Joseph , Erickson Christopher C. , Cecchin Frank , Dubin Anne M. , Law Ian H. , Cohen Mitchell I. , LaPage Martin J. , Cannon Bryan C. , Chun Terrence U.H. , Freedenberg Vicki , Gierdalski Marcin , Berul Charles I. 
Published: May 2013

Background—
Implantable cardioverter-defibrillator (ICD) therapy in children and congenital heart disease patients is hampered by poor long-term lead survival. Lead extraction is technically difficult and carries substantial morbidity. We sought to determine the outcomes of ICD leads in pediatric and congenital heart disease patients.

Methods and Results—

The Pediatric Lead Extractability and Survival Evaluation (PLEASE) is a 24-center international registry. Pediatric and congenital heart disease patients with ICD lead implantations from 2005 to 2010 were eligible. Study subjects comprised 878 ICD patients (44% congenital heart disease). Mean±SD age at implantation was 18.6±9.8 years. Of the 965 total leads, 54% were thin (≤7F), of which 57% were Fidelis, and 23% were coated with expanded polytetrafluoroethylene. There were 139 ICD lead failures (14%) in 132 patients (15%) at a mean lead age of 2.0±1.4 years, causing shocks in 53 patients (40%). Independent predictors of lead failure included younger implantation age and Fidelis leads. Actuarial analysis showed an incremental risk of lead failure with younger age at implantation: <8 years compared with >18 years (
P
=0.015). The actuarial yearly failure rate was 2.3% for non-Fidelis and 9.1% for Fidelis leads. Extraction was performed on 143 leads (80% thin, 7% expanded polytetrafluoroethylene coated), with lead age as the only independent predictor for advanced extraction techniques. There were 6 major extraction complications (4%) but no procedural mortality.

Conclusions—
This study demonstrates that ICD leads in children and congenital heart disease patients have an age-related suboptimal performance, further compounded by a high failure rate of Fidelis leads. Advanced extraction techniques were common and correlated with older lead age.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00335036.
Role of Balloon-Expandable Stents in Intracranial Atherosclerotic Disease in a Series of 182 Patients
Authors: Alurkar Anand , Karanam Lakshmi Sudha Prasanna , Oak Sagar , Nayak Suresh , Sorte Sandeep 
Published: May 2013

Background and Purpose—
To demonstrate the safety and efficacy of balloon-expandable intracranial stents in patients with intracranial atherosclerotic lesions (>70% stenosis) who were symptomatic despite being on optimum medical therapy.

Methods—
Between April 2004 and May 2012, 182 patients underwent intracranial stenting in our institution. All patients had symptoms despite being on optimum medical therapy. Clinical follow-up was done at 1, 3, 6, and 12 months. Angiographic follow-up was done at 1 year in 121 patients.

Results—
Technical success was achieved in 97.44% of the cases. The incidence of all strokes at 1 month after procedure was 11 (5.64%), of which 2 (1.02%) were major, both related to stent thrombosis not responding to tirofiban, and 9 (4.61%) were minor. Periprocedural minor stroke was seen in 9 patients. There were 2 deaths in our study (mortality=1.09%).

Conclusions—
Treatment of intracranial atherosclerotic disease with balloon-expandable intracranial stents is a safe and effective method with acceptable adverse events, especially in patients who failed medical therapy and were symptomatic despite being on optimum medical therapy.
Aversive Pavlovian Control of Instrumental Behavior in Humans
Authors: Geurts Dirk E. M. , Huys Quentin J. M. , den Ouden Hanneke E. M. , Cools Roshan 
Published: May 2013

AbstractAdaptive behavior involves interactions between systems regulating Pavlovian and instrumental control of actions. Here, we present the first investigation of the neural mechanisms underlying aversive Pavlovian–instrumental transfer using fMRI in humans. Recent evidence indicates that these Pavlovian influences on instrumental actions are action-specific: Instrumental approach is invigorated by appetitive Pavlovian cues but inhibited by aversive Pavlovian cues. Conversely, instrumental withdrawal is inhibited by appetitive Pavlovian cues but invigorated by aversive Pavlovian cues. We show that BOLD responses in the amygdala and the nucleus accumbens were associated with behavioral inhibition by aversive Pavlovian cues, irrespective of action context. Furthermore, BOLD responses in the ventromedial prefrontal cortex differed between approach and withdrawal actions. Aversive Pavlovian conditioned stimuli modulated connectivity between the ventromedial prefrontal cortex and the caudate nucleus. These results show that action-specific aversive control of instrumental behavior involves the modulation of fronto-striatal interactions by Pavlovian conditioned stimuli.
Cognitive Control of Distinct Vocalizations in Rhesus Monkeys
Authors: Hage Steffen R. , Gavrilov Natalja , Nieder Andreas 
Published: May 2013

Abstract
Whether nonhuman primates can decouple their innate vocalizations from accompanied levels of arousal or specific events in the environment to achieve cognitive control over their vocal utterances has been a matter of debate for decades. We show that rhesus monkeys can be trained to elicit different call types on command in response to arbitrary visual cues. Furthermore, we report that a monkey learned to switch between two distinct call types from trial to trial in response to different visual cues. A controlled behavioral protocol and data analysis based on signal detection theory showed that noncognitive factors as a cause for the monkeys' vocalizations could be excluded. Our findings also suggest that monkeys also have rudimentary control over acoustic call parameters. These findings indicate that monkeys are able to volitionally initiate their vocal production and, therefore, are able to instrumentalize their vocal behavior to perform a behavioral task successfully.
Tea Ceremony as a Space for Interreligious Dialogue
Authors: Hioki Naoko Frances 
Published: May 2013

Abstract
This paper explores the potential of Japanese tea ceremony to be an aesthetic space for inter-religious dialogue. Through a study of historical encounters that took place between European Jesuit missionaries and Japanese tea masters in the late 16th century, this paper elucidates the missionaries’ experiences of tea ceremonies and discusses the validity and limitation of a tea house as a space for cross-cultural and interreligious dialogue. The fruit of tea ceremony in terms of interreligious dialogue includes a shared sense of aesthetic communion that is attained through communal enjoyment of the beauty of nature and drinking a cup of tea in an isolated tea house, where guests are invited to cast away worries of everyday business, as well as their social and religious differences; whereas its limitation pertains to marked indifference toward verbal communication that is characteristic to the way of tea, and thus the historical missionaries’ experience was limited to aesthetic paradigm and did not lead to logical understanding of doctrinal differences between Buddhists and Christians.
The Crisis Model for Managing Change in African Christianity: The Story of St John’s Apostolic Church
Authors: Masondo Sibusiso 
Published: May 2013

Abstract
St John’s Apostolic Faith Mission, founded by Christinah Nku (also known as Mme Christinah) and all its splinter groups can be theorized as presenting a crisis model for managing change. These churches provide their members with a well worked out path of inclusion through baptism and related rituals, as well as, alleviation of crisis through an assortment of healing, cleansing and deliverance rituals. There is also a strong element of maintaining a person’s healing through an assortment of rituals of celebration and ideological reinforcement. They do this through a process of resource mobilization from both Christianity and African Religion to set up a religion that adequately responds to both the existential and spiritual needs of their members.
Recovery of Posttraumatic Migraine Characteristics in Patients After Mild Traumatic Brain Injury
Authors: Mihalik Jason P. , Register-Mihalik Johna , Kerr Zachary Y. , Marshall Stephen W. , McCrea Michael C. , Guskiewicz Kevin M. 
Published: May 2013

Background: Headache-related symptoms may be predictive of delayed recovery in student athletes after sport-related concussion. Purpose and Hypothesis: To compare balance performance, cognitive function, and symptom recovery in concussed student athletes with no headache, those with posttraumatic headache, and those with characteristics of posttraumatic migraine following a sport-related concussion. It was hypothesized that those with posttraumatic migraine would take longer to recover on all clinical measures. Study Design: Cohort study (prognosis); Level of evidence, 2. Methods: A total of 296 student athletes who sustained sport-related concussions (migraine, 52; headache, 176; no headache, 68) were evaluated on measures of balance performance, cognition, and symptoms. Patients were categorized into posttraumatic migraine, posttraumatic headache, and no headache groups based on symptoms reported 1 day after injury. Serial testing was conducted with the Balance Error Scoring System, the Standardized Assessment of Concussion, and a graded symptom checklist to evaluate balance performance, cognition, and symptoms, respectively, at baseline, at the time of injury, after the event, and at days 1, 2, 3, 5, 7, and 90. Results: Student athletes with posttraumatic migraine experienced greater symptom severity scores than did those with posttraumatic headache and no headache at the time of injury, after the event, and through day 7 ( P < .001 for all). By day 7, symptom severity scores reported by patients with posttraumatic migraine still demonstrated deficits relative to baseline (Δ = 5.6 ± 1.2) compared with patients with headache (Δ = −0.8 ± 0.7) and those with no headache (Δ = −1.4 ± 1.1). Patients with headache experienced greater symptom severity scores than patients with no headache at the time of injury ( P < .001), after the event ( P < .001), and at day 1 ( P < .001), day 2 ( P = .005), and day 3 ( P = .038). Much smaller differences were observed between the headache and no headache groups beyond day 3 ( P > .05). There were no group differences on balance performance ( P = .439) and cognitive testing ( P = .200) over time. Female patients were 2.13 times more likely than males to report posttraumatic migraine characteristics after concussion. Conclusion: Posttraumatic migraine characteristics are related to prolonged symptom recovery after sport-related concussion. Clinicians should exercise caution in making decisions about return to participation for athletes with migraine-like symptoms given the increased short-term impairments and delayed symptom recovery we observed.