bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chronic TLR Stimulation Controls NLRP3 Inflammasome Activation through IL-10 Mediated Regulation of NLRP3 Expression and Caspase-8 Activation
Authors: Gurung Prajwal , Li Bofeng , Subbarao Malireddi R. K. , Lamkanfi Mohamed , Geiger Terrence L. , Kanneganti Thirumala-Devi 
Published: September 2015

AbstractWhile the molecular mechanisms promoting activation of the Nod-like Receptor (NLR) family member NLRP3 inflammasome are beginning to be defined, little is known about the mechanisms that regulate the NLRP3 inflammasome. Acute (up to 4 hours) LPS stimulation, followed by ATP is frequently used to activate the NLRP3 inflammasome in macrophages. Interestingly, we observed that the ability of LPS to license NLRP3 is transient, as prolonged (12 to 24 hours) LPS exposure was a relatively ineffective priming stimulus. This suggests that relative to acute LPS, chronic LPS exposure triggers regulatory mechanisms to dampen NLRP3 activation. Transfer of culture supernatants from macrophages stimulated with LPS for 24 hours dramatically reduced ATP- and nigericin-induced NLRP3 inflammasome activation in naïve macrophages. We further identified IL-10 as the secreted inflammasome-tolerizing factor that acts in an autocrine manner to control activation of the NLRP3 inflammasome. Finally, we demonstrated that IL-10 dampens NLRP3 expression to control NLRP3 inflammasome activation and subsequent caspase-8 activation. In conclusion, we have uncovered a mechanism by which chronic, but not acute, LPS exposure induces IL-10 to dampen NLRP3 inflammasome activation to avoid overt inflammation.
Substrate-induced interfacial plasmonics for photovoltaic conversion
Authors: Li Xinxi , Jia Chuancheng , Ma Bangjun , Wang Wei , Fang Zheyu , Zhang Guoqing , Guo Xuefeng 
Published: September 2015

AbstractSurface plasmon resonance (SPR) is widely used as light trapping schemes in solar cells, because it can concentrate light fields surrounding metal nanostructures and realize light management at the nanoscale. SPR in photovoltaics generally occurs at the metal/dielectric interfaces. A well-defined interface is therefore required to elucidate interfacial SPR processes. Here, we designed a photovoltaic device (PVD) with an atomically flat TiO2 dielectric/dye/graphene/metal nanoparticle (NP) interface for quantitatively studying the SPR enhancement of the photovoltaic conversion. Theoretical and experimental results indicated that the graphene monolayer was transparent to the electromagnetic field. This transparency led to significant substrate-induced plasmonic hybridization at the heterostructure interface. Combined with interparticle plasmonic coupling, the substrate-induced plasmonics concentrated light at the interface and enhanced the photo-excitation of dyes, thus improving the photoelectric conversion. Such a mechanistic understanding of interfacial plasmonic enhancement will further promote the development of efficient plasmon-enhanced solar cells and composite photocatalysts.
Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation
Authors: Tsuchiya Megumi , Isogai Shin , Taniguchi Hiroaki , Tochio Hidehito , Shirakawa Masahiro , Morohashi Ken-ichirou , Hiraoka Yasushi , Haraguchi Tokuko , Ogawa Hidesato 
Published: September 2015

AbstractTranscriptional coregulators contribute to several processes involving nuclear receptor transcriptional regulation. The transcriptional coregulator androgen receptor-interacting protein 4 (ARIP4) interacts with nuclear receptors and regulates their transcriptional activity. In this study, we identified p62 as a major interacting protein partner for ARIP4 in the nucleus. Nuclear magnetic resonance analysis demonstrated that ARIP4 interacts directly with the ubiquitin-associated (UBA) domain of p62. ARIP4 and ubiquitin both bind to similar amino acid residues within UBA domains; therefore, these proteins may possess a similar surface structure at their UBA-binding interfaces. We also found that p62 is required for the regulation of ARIP4 protein levels under nutrient starvation conditions. We propose that p62 is a novel binding partner for ARIP4 and that its binding regulates the cellular protein level of ARIP4 under conditions of metabolic stress.
Global diversity patterns in sandy beach macrofauna: a biogeographic analysis
Authors: Barboza Francisco Rafael , Defeo Omar 
Published: September 2015

AbstractUnlike the advances generated on land, the knowledge of global diversity patterns in marine ecosystems is limited to a small number of studies. For sandy beaches, which dominate the world’s ocean shores, previous meta-analyses highlighted the role of beach morphodynamics in explaining species richness patterns. Oceanographic variables and historical processes have not been considered, even though they could be main predictors of community structure. Our work, based on 256 sandy beaches around the world, analysed species richness considering for the first time temperature, salinity and primary productivity. Biogeographic units (realms, provinces and ecoregions) were used to incorporate historical factors in modelling processes. Ecoregions, which implicitly include isolation and coastal complexity among other historical geographic factors, best represented trends in species richness worldwide. Temperature was a main predictor of species richness, which increased from temperate to tropical sandy beaches. Species richness increased with tide range and towards wide beaches with gentle slopes and fine grains, which is consistent with the hypothesis that habitat availability has an important role in structuring sandy beach communities. The role of temperature and habitat availability suggests that ocean warming and sea level rise could affect the distribution of obligate species living in these narrow ecosystems.
Scalable Sub-micron Patterning of Organic Materials Toward High Density Soft Electronics
Authors: Kim Jaekyun , Kim Myung-Gil , Kim Jaehyun , Jo Sangho , Kang Jingu , Jo Jeong-Wan , Lee Woobin , Hwang Chahwan , Moon Juhyuk , Yang Lin , Kim Yun-Hi , Noh Yong-Young , Yun Jaung Jae , Kim Yong-Hoon , Kyu Park Sung 
Published: September 2015

AbstractThe success of silicon based high density integrated circuits ignited explosive expansion of microelectronics. Although the inorganic semiconductors have shown superior carrier mobilities for conventional high speed switching devices, the emergence of unconventional applications, such as flexible electronics, highly sensitive photosensors, large area sensor array and tailored optoelectronics, brought intensive research on next generation electronic materials. The rationally designed multifunctional soft electronic materials, organic and carbon-based semiconductors, are demonstrated with low-cost solution process, exceptional mechanical stability and on-demand optoelectronic properties. Unfortunately, the industrial implementation of the soft electronic materials has been hindered due to lack of scalable fine-patterning methods. In this report, we demonstrated facile general route for high throughput sub-micron patterning of soft materials, using spatially selective deep-ultraviolet irradiation. For organic and carbon-based materials, the highly energetic photons (e.g. deep-ultraviolet rays) enable direct photo-conversion from conducting/semiconducting to insulating state through molecular dissociation and disordering with spatial resolution down to a sub-μm-scale. The successful demonstration of organic semiconductor circuitry promise our result proliferate industrial adoption of soft materials for next generation electronics.
Novel nano bearings constructed by physical adsorption
Authors: Zhang Yongbin 
Published: September 2015

AbstractThe paper proposes a novel nano bearing formed by the physical adsorption of the confined fluid to the solid wall. The bearing is formed between two parallel smooth solid plane walls sliding against one another, where conventional hydrodynamic lubrication theory predicted no lubricating effect. In this bearing, the stationary solid wall is divided into two subzones which respectively have different interaction strengths with the lubricating fluid. It leads to different physical adsorption and slip properties of the lubricating fluid at the stationary solid wall respectively in these two subzones. It was found that a significant load-carrying capacity of the bearing can be generated for low lubricating film thicknesses, because of the strong physical adsorption and non-continuum effects of the lubricating film.
Ternary Phase-Separation Investigation of Sol-Gel Derived Silica from Ethyl Silicate 40
Authors: Wang Shengnan , Wang David K. , Smart Simon , Diniz da Costa João C. 
Published: September 2015

AbstractA ternary phase-separation investigation of the ethyl silicate 40 (ES40) sol-gel process was conducted using ethanol and water as the solvent and hydrolysing agent, respectively. This oligomeric silica precursor underwent various degrees of phase separation behaviour in solution during the sol-gel reactions as a function of temperature and H2O/Si ratios. The solution composition within the immiscible region of the ES40 phase-separated system shows that the hydrolysis and condensation reactions decreased with decreasing reaction temperature. A mesoporous structure was obtained at low temperature due to weak drying forces from slow solvent evaporation on one hand and formation of unreacted ES40 cages in the other, which reduced network shrinkage and produced larger pores. This was attributed to the concentration of the reactive sites around the phase-separated interface, which enhanced the condensation and crosslinking. Contrary to dense silica structures obtained from sol-gel reactions in the miscible region, higher microporosity was produced via a phase-separated sol-gel system by using high H2O/Si ratios. This tailoring process facilitated further condensation reactions and crosslinking of silica chains, which coupled with stiffening of the network, made it more resistant to compression and densification.
Atomic-scale diffractive imaging of sub-cycle electron dynamics in condensed matter
Authors: Yakovlev Vladislav S. , Stockman Mark I. , Krausz Ferenc , Baum Peter 
Published: September 2015

AbstractFor interaction of light with condensed-matter systems, we show with simulations that ultrafast electron and X-ray diffraction can provide a time-dependent record of charge-density maps with sub-cycle and atomic-scale resolutions. Using graphene as an example material, we predict that diffraction can reveal localised atomic-scale origins of optical and electronic phenomena. In particular, we point out nontrivial relations between microscopic electric current and density in undoped graphene.
Principles of studying a cell - a non-boastful paper for all molecular biologists
Authors: Chen Han , He Xionglei 
Published: September 2015

SummaryStudies of a cell rely on either observational approaches or perturbational/genetic approaches to define the contribution of a gene to specific cellular traits. It is unclear, however, under what circumstances each of the two approaches can be most successful and when they are doomed to fail. By analyzing over 500 complex traits of the yeastSaccharomyces cerevisiaewe show that the trait relatedness to fitness determines the performance of observational approaches. Specifically, in traits subject to strong natural selection, genes identified using observational approaches are often highly coordinated in expression, such that the gene-trait associations are readily recognizable; in sharp contrast, the lack of such coordination in traits subject to weak selection leads to no detectable activity-trait associations for any individual genes and thus the failure of observational approaches. We further show that genetic approaches can be successful when the genes responsible for coordinating the target genes of observational approaches are perturbed. However, because the system-level cellular responses to a random mutation affect more or less every gene and consequently every trait, most genetic effects convey no trait-specific functional information for understanding the traits, which is particularly true for traits subject to weak selection.Significance statementCell research is nearly exclusively based on empirical data obtained through either observational approaches or perturbational/genetic approaches. It is, however, increasingly clear that an analytical framework able to guide the empirical strategies is necessary to drive the field further ahead. This study analyzes ~500 complex traits of the yeastSaccharomyces cerevisiaeand reveals the organizing principles of a cell. Specifically, a cell can be viewed as a factory, with each trait being the product of a production line operated directly by workers who are supervised by managers. For a cellular trait produced by many workers, the coordination level of the workers determines the performance of observational approaches. Meanwhile, the coordination of workers is realized by managers that are recruited and/or maintained by natural selection. Thus, observational approaches are expected to fail for traits subject to little selection, and genetic approaches can be successful only when the managers of fitness-tightly-coupled traits are perturbed. The manager-worker architecture built by natural selection explains well the origins of global epistasis and ubiquitous genetic effects, two major issues confusing current genetics and molecular and cellular biology, providing a clear guideline on how to study a cell.
Green supply chain management (GSCM): a structured literature review and research implications
Authors: Malviya Rakesh Kumar , Kant Ravi 
Published: September 2015

Purpose
– The purpose of this paper is to examine the status of green supply chain management (GSCM) research in terms of how the field is represented along a number of dimensions including journal, year, country, university, publishing house, authors, research design, research methods, data analysis techniques, multi criteria decision-making methods, research topics/issues and major industries actively involved.

Design/methodology/approach
– A range of online databases from 1998 to August 2013 were searched containing the word “green supply chain” in their title and in the phrases to provide a comprehensive listing of journal articles on GSCM. Based on this a total of 177 articles were found and the information on a series of variables was gathered. Each of these articles was further reviewed and classified. The review and classification process was independently verified. All papers were allocated to the main and sub-categories based on the major focus.

Findings
– The major findings shows that survey research holds greater credibility and the trend in survey research is moving from exploratory to model building and testing. GSCM research related to organizational practices, environmental issues, process, performance and sustainability were found to be most widely published topics within the GSCM domain.

Research limitations/implications
– This paper is limited in reviewing those articles which contains the word “green supply chain” in the title and the phrases of the articles.

Originality/value
– The present review will provide increased understanding of the current state of research and what still needs to be investigated in the GSCM discipline.
A content analysis of global supply chain research
Authors: Ibrahim Hadiyan Wijaya , Zailani Suhaiza , Tan Keah Choon 
Published: September 2015

Purpose– The purpose of this paper is to use content analysis to review the extensive supply chain literature to summarize its past and current trends, and uncover existing gaps and opportunities for future global supply chain research.Design/methodology/approach– Since the study uses content analysis, several dimensions of the literature were analyzed: research purpose, year of publication, journal name, methodology, theory building or verification, country of study, sample industry, global or non-global issues, and article classification.Findings– From a methodological point, the literature mostly consists of empirical and descriptive studies with few exploratory articles. The review shows that global supply chains area relatively “immature” or “new phenomenon” research topic that is gaining interest from practitioners and academics.Research limitations/implications– It is hoped that by critically examining the extant literature, the authors can clearly identify the challenges and state of global supply chain research to provide supply chain researchers with a precise summary of the literature and directions for future studies.Practical implications– This study also allows managers to recognize the methodologies and tools that can be used to enhance their supply chains. It is believed that various strategies could be adopted to create a robust global supply chain. In this respect, different industry sectors may require different global strategies and different global practices.Originality/value– The findings show that there is a shortage of empirical studies on global supply chain strategies and outcomes, and most research focusses on supply chain practices and customer or supplier relationships.
Factors affecting the ERP implementation in Indian retail sector
Authors: Garg Poonam , Chauhan Ajay 
Published: September 2015

Purpose– The purpose of this paper is to make an effort in identifying and exploring the factors which may affect the success of ERP implementation in Indian retail sector. This paper also analyses the between the factors and their impact on the successful implementation of ERP using the structured equation modeling (SEM) approach. “Organizational,” “Technological,” “People” and “Project Management” are the examined factors.Design/methodology/approach– A theoretical model is created that explains the factors which may affect the success of ERP implementation. Hypotheses were also developed to evaluate the interrelationship between affecting factors and success of ERP implementation. Empirical data is collected through survey questionnaire from practitioner like project sponsors, project managers, implementation consultants and team members who are involved in ERP implementation in retail sector to test the theoretical model.Findings– Using SEM, it is found that 62.7 percent of the variations of ERP implementation success can be explained with the help of the model suggested in the research study. The finding also confirms that there is significant positive interrelationship between “Organizational,” “Technological,” “People,” “Project Management” and success of ERP implementation in Indian retail sector.Research limitations/implications– The research is subject to the normal limitations of survey research. The study is using perceptual data provided by project sponsors, project managers, implementation consultants and team members who are involved in ERP implementation in retail sector, which may not provide clear measures of performance. However, this can be overcome using multiple methods to collect data in future studies.Practical implications– Findings from this paper can provide greater understanding in the area of ERP implementation. This study will provide valuable insights to researchers, practicing managers and those who are planning to implement ERP in retail sector.Originality/value– The study integrates the affecting factor with success of ERP implementation, i.e. “Organizational,” “Technological,” “People” and “Project Management” are the key drivers for the effectiveness and success of ERP implementation in Indian retail sector. Very few studies have been performed to investigate and understand this issue. Therefore, the research can make a useful contribution.
Developing the capability of marketing intelligence
Authors: Lin Wei-Shong , Hsu Jing-Wen , Yeh Ming-Yih 
Published: September 2015

Purpose– The purpose of this paper is to help firms to create competitiveness by developing marketing capabilities. It analyzes how the component and architectural competences affect and enhance market orientation and firm performance.Design/methodology/approach– Built on the theories of organizational capability, knowledge creation, and market orientation, this research develops the contents of marketing capabilities, including component and architectural competences that contribute to marketing capability by responding to external changes, and analyzes their influence on market orientation and firm performance.Findings– The study reveals the following effective marketing capabilities which benefit to marketing performance. First, hiring and retaining employees with higher professional, local, and specific knowledge. Second, firms with higher tacit knowledge enhance market orientation. Third, arranging employees into teamwork to implement marketing tasks. Fourth, assigning employees into small-scale experiments on creative proposals. Fifth, standardizing procedures of generation, dissemination, and response of marketing intelligence. Sixth, providing written market information and training programs to non-marketing staff. Seventh, appropriately delegating to staff. Eighth, establishing apprenticeship among the staff to deliver experiential know-how.Research limitations/implications– From a dynamic capability perspective, this research construct the two kinds of marketing competences and examine their effect on market orientation and firm performance. For further understanding the complementary effects of marketing capabilities, market orientation, and synergistic performance, a larger sample data (e.g. product, market share, sales, characteristics of staff, firm, and knowledge, etc.) and objective evaluation are encouraged. Otherwise, from the viewpoint of agency theory, the incentive system should also be discussed.Practical implications– This research has potentially significant implications for knowledge management and marketing management fields as well as managerial practice. The results suggest the importance of marketing capability for market orientation and firm performance.Originality/value– Marketing resources and marketing capabilities are significant drivers of firm performance, and their impact is greater when they are complementary to each other. This study takes the perspectives of organizational capabilities and market orientation to find out the factors which contribute to marketing capability and performance. This study provides practitioners with a framework for analyzing marketing capabilities as an object of improving firm performance by creating market orientation. Furthermore, this research empirically introduced strategic specific competence (tacit knowledge and autonomy) into the model and tests their effect of market orientation and firm performance.