bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discontinuation of neoadjuvant therapy does not influence postoperative short-term outcomes in elderly patients (≥ 70 years) with resectable gastric cancer: a population-based study from the dutch upper gastrointestinal cancer audit (DUCA) data
Authors: Wang Jingpu , Wu Zhouqiao , de Groot Eline M. , Challine Alexandre , Mohammad Nadia Haj , Mook Stella , Goense Lucas , Ruurda Jelle P. , van Hillegersberg Richard 
Published: June 2024

Abstract
Background
For the elderly patients with gastric cancer, it may be more challenging to tolerate complete neoadjuvant therapy (NAT). The impact of discontinued NAT on the surgical safety and pathological outcomes of elderly patients with poor tolerance remains poorly understood.

Methods
Gastric cancer patients received gastrectomy with curative intent from the Dutch upper GI cancer audit (DUCA) database were included in this study. The independent association of age with not initiating and discontinuation of NAT was assessed with restricted cubic splines (RCS). According to the RCS results, age ≥ 70 years was defined as elderly. Short-term postoperative outcomes and pathological results were compared between elderly patients who completed and discontinued NAT.

Results
Between 2011- 2021, total of 3049 patients were included. The risk of not initiating NAT increased from 70 years. In 1954 (64%) patients receiving NAT, the risk of discontinuation increased from 55 years, reaching the peak around 74 years. In the elderly, discontinued NAT was not independently associated with worse 30-day mortality, overall complications, anastomotic leakage, re-intervention, and pathologic complete response, but was associated with a higher risk of R1/2 resection (p-value = 0.001), higher ypT stage (p-value = 0.004), ypN + (p-value = 0.008), and non-response ( p-value = 0.012).

Conclusion
A decreased utilization of NAT has been observed in Dutch gastric cancer patients from 70 years due to old age considerations, possibly because of their high risk of discontinuation. Increasing the utilization of NAT may not adversely impact the surgical safety of gastric cancer population ≥ 70 years and may contribute to better pathological results.
Walking recovery after tethered cord release
Authors: AbdelFatah Mohamed AR , Ibrahim Aly , Hefny Sameh 
Published: June 2024

AbstractAfter myelomeningocele (MMC) repair, a secondary tethered spinal cord occurs in almost all patients. The tethered spinal cord may result in progressive neurological deterioration and walking disability. This retrospective cohort study aimed to highlight the walking recovery one year after tethered cord release and its relation to the preoperative conus level. We reviewed the medical records at our university hospital from January 2014 to December 2022. The patients who underwent spinal cord untethering following lumbosacral MMC repair were included. We assessed the walking recovery one year after cord release using the modified Benzel scale. Thirty-seven patients met our selection criteria. There were 19 girls (51.4%) and 18 boys (48.6%). Their mean age at presentation was 8.6 years. The preoperative conus vertebral levels ranged between L4 and S3. One year after spinal cord release, 37.8% of the patients regained their walking ability. All the patients whose preoperative conus level was at S2 or S3 regained their walking ability. In contrast, all the patients with preoperative conus levels at L4 or L5 didn’t regain their ability to walk. One-third (33.3%) of patients whose conus was at the S1 level regained their walking ability one year after cord release. One year after tethered cord release, 37.8% of the patients regained their walking ability. We found that the walking recovery was statistically associated with the preoperative conus level. A multicenter prospective study is required to support the results of this study.
Representation of stochastic optimal control problems with delay in the control variable
Authors: Girolami Cristina Di , Rosestolato Mauro 
Published: June 2024

AbstractIn this manuscript we provide a representation in infinite dimension for stochastic optimal control problems with delay in the control variable. The main novelty consists in the fact that the representation can be applied also to dynamics where the delay in the control appears as a nonlinear term and in the diffusion coefficient. We then apply the representation to a LQ case where an explicit solution can be found.
General birationality and hyperelliptic theta divisors
Authors: Catanese Fabrizio 
Published: June 2024

Abstract
We first state a condition ensuring that having a birational map onto the image is an open property for families of irreducible normal non uniruled varieties. We give then some criteria to ensure general birationality for a family of rational maps, via specializations. Among the applications is a new proof of the main result of Catanese and Cesarano (Electron Res Arch 29(6):4315–4325, 2021) that, for a general pair (A, X) of an (ample) Hypersurface X in an Abelian Variety A, the canonical map

$$\Phi _X$$

Φ
X

of X is birational onto its image if the polarization given by X is not principal. The proof is also based on a careful study of the Theta divisors of the Jacobians of Hyperelliptic curves, and some related geometrical constructions. We investigate these here also in view of their beauty and of their independent interest, as they lead to a description of the rings of Hyperelliptic theta functions.
Left-invariant almost complex structures on the higher dimensional Kodaira–Thurston manifolds
Authors: Holt Tom , Piovani Riccardo 
Published: June 2024

AbstractWe develop computational techniques which allow us to calculate the Kodaira dimension as well as the dimension of spaces of Dolbeault harmonic forms for left-invariant almost complex structures on the generalised Kodaira–Thurston manifolds.
Social small group optimization algorithm for large-scale economic dispatch problem with valve-point effects and multi-fuel sources
Authors: Secui Dinu Calin , Secui Monica Liana 
Published: June 2024

AbstractEconomic dispatch is an important issue in the management of power systems and is the current focus of specialists. In this paper, a new metaheuristic optimization algorithm is proposed, named Social Small Group Optimization (SSGO), inspired by the psychosocial processes that occur between members of small groups to solve real-life problems. The starting point of the SSGO algorithm is a philosophical conception similar to that of the social group optimization (SGO) algorithm. The novelty lies in the introduction of the small group concept and the modeling of individuals’ evolution based on the social influence between two or more members of the small group. This conceptual framework has been mathematically mapped through a set of heuristics that are used to update the solutions, and the best solutions are retained by employing a greedy selection strategy. SSGO has been applied to solve the economic dispatch problem by considering some practical aspects, such as valve-point loading effects, sources with multiple fuel options, prohibited operating zones, and transmission line losses. The efficiency of the SSGO algorithm was tested on several mathematical functions (unimodal, multimodal, expanded, and composition functions) and on power systems of varying sizes (ranging from 10-units to 1280-units). The SSGO algorithm was compared with SGO and other algorithms belonging to various categories (such as: evolution-based, swarm-based, human behavior-based, hybrid algorithms, etc.), and the results indicated that SSGO outperforms other algorithms applied to solve the economic dispatch problem in terms of quality and stability of the solutions, as well as computation time.
Heavy-metal associated breast cancer and colorectal cancer hot spots and their demographic and socioeconomic characteristics
Authors: Tomlinson Madeline M. , Pugh Felicia , Nail Alexandra N. , Newton Johnnie D. , Udoh Karen , Abraham Stephie , Kavalukas Sandy , Guinn Brian , Tamimi Rulla M. , Laden Francine , Iyer Hari S. , States J. Christopher , Ruther Matthew , Ellis C. Tyler , DuPré Natalie C. 
Published: June 2024

Abstract
Purpose
Cancer registries offer an avenue to identify cancer clusters across large populations and efficiently examine potential environmental harms affecting cancer. The role of known metal carcinogens (i.e., cadmium, arsenic, nickel, chromium(VI)) in breast and colorectal carcinogenesis is largely unknown. Historically marginalized communities are disproportionately exposed to metals, which could explain cancer disparities. We examined area-based metal exposures and odds of residing in breast and colorectal cancer hotspots utilizing state tumor registry data and described the characteristics of those living in heavy metal-associated cancer hotspots.

Methods
Breast and colorectal cancer hotspots were mapped across Kentucky, and area-based ambient metal exposure to cadmium, arsenic, nickel, and chromium(VI) were extracted from the 2014 National Air Toxics Assessment for Kentucky census tracts. Among colorectal cancer (n = 56,598) and female breast cancer (n = 77,637) diagnoses in Kentucky, we used logistic regression models to estimate Odds Ratios (ORs) and 95% Confidence Intervals to examine the association between ambient metal concentrations and odds of residing in cancer hotspots, independent of individual-level and neighborhood risk factors.

Results
Higher ambient metal exposures were associated with higher odds of residing in breast and colorectal cancer hotspots. Populations in breast and colorectal cancer hotspots were disproportionately Black and had markers of lower socioeconomic status. Furthermore, adjusting for age, race, tobacco and neighborhood factors did not significantly change cancer hotspot ORs for ambient metal exposures analyzed.

Conclusion
Ambient metal exposures contribute to higher cancer rates in certain geographic areas that are largely composed of marginalized populations. Individual-level assessments of metal exposures and cancer disparities are needed.
Phase-Based Care in Community Mental Health: A Cost-Effective Innovation Using Algorithms, Rating Scales and Treatment Teams for Depression Management
Authors: Rosen Jules , Hoy Michelle 
Published: June 2024

AbstractThis retrospective, observational report describes an innovative quality improvement process, Phase-based Care (PBC), that eliminated wait times and achieved positive clinical outcomes in a community mental health center’s (CMHC) mood disorder clinic without adding staff. PBC accomplishes this by eliminating the ingrained cultural practice of routinely scheduling stable patients at rote intervals of 1–3 months, regardless of clinical need or medical necessity. Based on four organizational transformations and using mathematical algorithms developed for this process, PBC re-allocates therapy and medical resources away from routinely scheduled appointments and front-loads those resources to patients in an acute phase of illness. To maintain wellness for patients in recovery, lower frequency and intensity approaches are used. This report describes the development of the PBC methodology focusing on the Rapid Recovery Clinic (RRC) comprised of 182 patients with a primary diagnosis of a mood disorder, the largest of the 14 PBC clinics created. Over an 18-month period, wait times were reduced from several months to less than one week and recovery rates, meaning no longer in an acute phase, were 63% and 78% at weeks 6 and 12, respectively for patients who engaged in the program.
Optimal Portfolios for Large Investors in Housing Markets Under Stress Scenarios: A Worst-Case Approach
Authors: Yilmaz Bilgi 
Published: June 2024

AbstractThe study focuses on constructing a mathematical housing market threatened by a major catastrophic event or crash. It incorporates the worst-case scenario portfolio optimization problem as introduced in Korn and Wilmott (Int J Theor Appl Finance 5(02):171–187, 2002) into housing markets. The standard stochastic models for housing markets assume a geometric Brownian motion and neglect sudden housing price falls during crash times. However, the size, timing, and frequency of crashes have to be included in such models. By incorporating the worst-case portfolio optimization problem into housing markets, this study introduces a methodology to construct portfolios for large investors that are robust and resilient to extreme housing market conditions. The worst-case portfolio optimization approach can be used in housing markets to incorporate stress scenarios, minimize potential losses, utilize mathematical techniques, and manage housing investment risk effectively. This study provides valuable insights for large investors seeking to construct housing portfolios prioritizing downside protection and minimizing losses in extreme housing market conditions. Utilizing numerical illustrations, it provides insights into portfolio construction, demonstrating the effectiveness of adjusting portfolios to mitigate downside risks during housing market crises. The results highlight dynamic portfolio management’s significance in safeguarding wealth when housing prices undergo significant fluctuations.
Self-Enforcing International Environmental Agreements and Altruistic Preferences
Authors: Schopf Mark 
Published: June 2024

AbstractThis paper analyses the effects of altruism on the formation of climate coalitions in the standard two-stage game of self-enforcing international environmental agreements with identical countries. Altruism implies that each country values, to some extent, every other country’s welfare when deciding on its coalition membership and emissions policy. In the Nash [Stackelberg] game, the fringe [coalition] countries exploit the altruism of the coalition [fringe] countries so that altruism decreases [increases] the coalition size. In any case, global emissions and global welfare are close to the non-cooperative values. However, altruism narrows the gap between the individually optimal emissions and the socially optimal emissions, so altruism increases global welfare. The effects of altruism on the formation of climate coalitions crucially depends on its modelling: If altruism affects the membership decision but not the policy decision, or if each coalition country is more altruistic toward other coalition countries than toward fringe countries, altruism can stabilise large coalitions up to the grand coalition. Finally, altruism can stabilise small coalitions but destabilises large coalitions with asymmetric countries.
Did Migrant Children Benefit from a Delay in the Dutch Primary School Exit Test?
Authors: Golsteyn Bart H. H. , Magnée Cécile , de Wolf Inge 
Published: June 2024

AbstractThis paper evaluates whether educational outcomes of first-generation migrant children improved relative to those of natives after a policy change which delayed an important primary school exit test by three months. Using Dutch register data and a difference-in-differences methodology, we show that the policy change increased the academic rank of migrants relative to natives upon first enrollment. The policy change, therefore, has had an important positive effect on the educational chances of migrant children. Our analyses suggest that the results are driven by higher relative exit test scores and higher relative teacher recommendations.
Particulate and gaseous air pollutants exceed WHO guideline values and have the potential to damage human health in Faisalabad, Metropolitan, Pakistan
Authors: Zeeshan Nukshab , Murtaza Ghulam , Ahmad Hamaad Raza , Awan Abdul Nasir , Shahbaz Muhammad , Freer-Smith Peter 
Published: June 2024

AbstractFirst-ever measurements of particulate matter (PM2.5, PM10, and TSP) along with gaseous pollutants (CO, NO2, and SO2) were performed from June 2019 to April 2020 in Faisalabad, Metropolitan, Pakistan, to assess their seasonal variations; Summer 2019, Autumn 2019, Winter 2019–2020, and Spring 2020. Pollutant measurements were carried out at 30 locations with a 3-km grid distance from the Sitara Chemical Industry in District Faisalabad to Bhianwala, Sargodha Road, Tehsil Lalian, District Chiniot. ArcGIS 10.8 was used to interpolate pollutant concentrations using the inverse distance weightage method. PM2.5, PM10, and TSP concentrations were highest in summer, and lowest in autumn or winter. CO, NO2, and SO2 concentrations were highest in summer or spring and lowest in winter. Seasonal average NO2 and SO2 concentrations exceeded WHO annual air quality guide values. For all 4 seasons, some sites had better air quality than others. Even in these cleaner sites air quality index (AQI) was unhealthy for sensitive groups and the less good sites showed Very critical AQI (> 500). Dust-bound carbon and sulfur contents were higher in spring (64 mg g−1) and summer (1.17 mg g−1) and lower in autumn (55 mg g−1) and winter (1.08 mg g−1). Venous blood analysis of 20 individuals showed cadmium and lead concentrations higher than WHO permissible limits. Those individuals exposed to direct roadside pollution for longer periods because of their occupation tended to show higher Pb and Cd blood concentrations. It is concluded that air quality along the roadside is extremely poor and potentially damaging to the health of exposed workers.
Graphical abstract
Complete exhaustion of dissolved nutrients in a large lowland river
Authors: Kamjunke Norbert , Sanders Tina 
Published: June 2024

AbstractRiverine phytoplankton takes up phosphate, dissolved silicate, and nitrate. We investigated which nutrients are depleted during a Lagrangian sampling in the free-flowing part of the River Elbe in 2023. As part of this study, we tested the hypotheses that nutrient depletion might be caused by (1) above-average phytoplankton biomass or by (2) decreased nutrient load of the river during previous years. Phytoplankton biomass increased up to 350 km in rivers and stopped increasing exactly when soluble reactive phosphorus had been completely consumed, and molar carbon to phosphorus ratios of seston indicated the beginning phosphorus limitation. The concentrations of dissolved silicate and nitrate dropped below the detection limit as well. In contrast to the results from eight previous longitudinal samplings taken in 2018–2022, nitrate exhaustion was detected for the first time in 2023 within the transect. This was caused neither by an above-average phytoplankton biomass nor by a declined overall nutrient load of the river in 2018–2023. Instead, denitrification appears to be the most plausible explanation for the downstream decrease of nitrate and the loss of total nitrogen which was supported by enrichment of nitrate stable isotopes and a decreasing ratio of nitrate 15N/18O.
Accelerated breeding strategies for biochemical marker-assisted backcross breeding and mapping population development in bread wheat (Triticum aestivum L.)
Authors: Aydin Nevzat , Demir Bedrettin , Akdag Halil , Gokmen Sabri , Sayaslan Abdulvahit , Bayraç Ceren , Sönmez Mesut Ersin , Türkoğlu Aras 
Published: June 2024

AbstractIn order to rapidly adapt to the evolving climate and sustainably nourish the growing global population, plant breeders are actively investigating more efficient strategies to enhance crop yields. In this study, we present the development of a bread wheat mapping population and backcross breeding program, serving as a valuable genetic resource for mapping the effects of different alleles on trait performance. We employed innovative methodologies to rapidly introgress traits into the bread wheat cultivar. Specifically, we utilized two parents, including Tosunbey x Tahirova2000, in a recombinant inbred line population, in addition, a backcross strategy was applied with line 148 (obtained by crossing Tosunbey x Tahirova2000 with high gluten quality) as the recipient parent of the Nevzatbey cv., known for its awnless feature. The two most important applications of the rapid breeding method are extending the light period and breaking dormancy in early harvested seeds. Both applications were successfully implemented in our study. Our vegetation periods ranging from approximately 50–60 days. Additionally, an early genotype in our developed population was harvested in 40 days. Considering that the genotype underwent a 15-day vernalization period, the generation cycle, including vernalization, drying, and refrigeration, was completed in a total of 64 days. Notably, we employed not only biochemical markers for selection but also incorporated the rapid generation advance technology known as ‘speed breeding’, allowing us to develop BC5F1 within a span of two years. We posit that this approach proves instrumental in swiftly transferring genes for multiple target traits into adapted wheat cultivars or in pyramiding desirable traits within elite breeding material.
Interspecific variation in the defensive responses of brown frogs to alien predators
Authors: Gazzola Andrea , Balestrieri Alessandro , Martinelli Mattia , Rocchetta Sara , Iori Alberto , Pellitteri-Rosa Daniele 
Published: June 2024

AbstractAlien species impact native amphibians through various direct effects, including predation, and pose a significant threat to naïve prey populations. In this study, we exposed tadpoles of three brown frog species (Rana dalmatina, Rana latastei, and Rana temporaria) to the olfactory cues of two alien predators, the pond slider (Trachemys scripta) and red swamp crayfish (Procambarus clarkii), and compared their responses to those induced by the aquatic larvae of a widespread native predator, the Southern hawker (Aeshna cyanea). We recorded two tadpole defensive behaviors, the proportion of time they were active and the number of freezing events. Both agile frog species, R. dalmatina and R. latastei, showed moderate responses to red swamp crayfish kairomones and strong responses to both odonate larvae and pond sliders. In contrast, the common frog (R. temporaria) displayed a less intense response to crayfish with respect to odonate larvae, and a negligible response to pond sliders. Long-lasting coexistence with either European pond turtles or pond sliders may explain the strength of agile frogs’ response toward the alien species; while, the historical range of the white-clawed crayfish (Austropotamobius pallipes) overlapped that of the common frog, enhancing the co-option of alien crayfish cues by this anuran species.