bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Generation of 4‐Cyanoisoquinolines and 4‐Amidylisoquinolines via a Palladium‐Catalyzed Cyanative Reaction of 2‐Alkynylbenzaldimines with Isocyanides.
Authors: Qiu Guanyinsheng , Qiu Xiaochen , Wu Jie 
Published: April 2014

AbstractThe Pd‐catalyzed reaction of substrates (I) and (IV) with isocyanides in dry acetonitrile provides 4‐cyanoquinolines as single products.
ChemInform Abstract: Nitrile Oxide versus Nitrone — Switching Regioselectivity of Intramolecular 1,3‐Dipolar Cycloadditions Towards the Preparation of Aminopiperidinecarboxylates.
Authors: Wuerdemann Martina , Christoffers Jens 
Published: April 2014

AbstractThe title cycloaddition yields compounds (II) and (X) which can be further functionalized.
ChemInform Abstract: Facile Access to 3‐Cyano‐4‐azaindoles via a Modified Madelung Indole Synthesis.
Authors: Jadhav Jagannath , Khanapaure Sharanabasappa , Kurane Rajanikant , Salunkhe Rajashri , Rashinkar Gajanan 
Published: April 2014

AbstractThe novel protocol allows the coupling of substrate (I) with carboxylic acids to give 3‐cyano‐4‐azaindoles in low to good yields.
ChemInform Abstract: Expedient Synthesis of Tetrafluorophenoxthiines and Derivatives by Copper(I)‐Catalyzed Cross‐Coupling Reaction.
Authors: Yu Chuanming , Hu Gaobo , Zhang Cuiling , Wu Ran , Ye Haiwei , Yang Guanghui , Shi Xiangjun 
Published: April 2014

AbstractPentafluorobenzene and aryl mercaptanes or the corresponding diaryl disulfides undergo an interesting oxidative coupling reaction to give tetrafluorophenoxthiines in moderate yields.
ChemInform Abstract: Novel Alkylaminopyridazine Derivatives: Synthesis and Their anti‐Proliferative Effects Against MCF‐7 Cells.
Authors: Kim Chaewon , Park Eun‐Hee , Park Myung‐Sook 
Published: April 2014

Abstract16 Title compounds of type (V) are prepared and tested for their anti‐proliferative effects against MCF‐7 cells.
ChemInform Abstract: Copper‐Catalyzed Domino Synthesis of 4‐Oxopyrimido[1,2‐a]indole Derivatives.
Authors: Wang Yuyuan , Wang Ruji , Jiang Yuyang , Tan Chunyan , Fu Hua 
Published: April 2014

AbstractThe reaction sequence involves sequential Cu‐catalyzed intermolecular C‐arylation of N‐(2‐halophenyl)‐3‐oxoalkanamides (I), intramolecular addition of NH to nitrile function, followed by nucleophilic attack of the formed amino group to the carbonyl moiety.
ChemInform Abstract: Unexpected Nitrilimine Cycloaddition of Thiazolo[3,2‐a]pyrimidine Derivatives.
Authors: Liu Bin , Li Xiao‐Fang , Liu Hao‐Chong , Yu Xian‐Yong 
Published: April 2014

AbstractThe 1,3‐dipolar cycloaddition of the in situ generated diphenylnitrilimine to substrate (I) proceeds regio‐ and site‐selectively.
ChemInform Abstract: Copper‐Catalyzed Oxidative Ring Closure and Carboarylation of 2‐Ethynylanilides.
Authors: Sinai Adam , Meszaros Adam , Gati Tamas , Kudar Veronika , Pallo Anna , Novak Zoltan 
Published: April 2014

AbstractA new copper‐catalyzed oxidative ring closure of ethynyl anilides with diaryliodonium salts is developed for the highly modular construction of benzoxazines bearing a fully substituted exo double bond.
ChemInform Abstract: Rearrangement of Benzylsulfanyl‐Substituted 2‐Aza‐1,3,5‐triene into 5‐Phenyl‐4,5‐dihydro‐1,3‐thiazole in the t‐BuOK‐THF‐DMSO System.
Authors: Nedolya N. A. , Tarasova O. A. , Albanov A. I. , Trofimov B. A. 
Published: April 2014

Abstract2‐Aza‐1,3,5‐triene (I) undergoes concurrent rearrangements leading to products (II), (III), and (IV).
ChemInform Abstract: Copper‐Catalyzed Borylation of α‐Alkoxy Allenes with Bis(pinacolato)diboron: Efficient Synthesis of 2‐Boryl 1,3‐Butadienes.
Authors: Semba Kazuhiko , Fujihara Tetsuaki , Terao Jun , Tsuji Yasushi 
Published: April 2014

AbstractThe reaction products can be used for Suzuki—Miyaura coupling reactions or Diels—Alder and hetero—Diels—Alder reactions.
ChemInform Abstract: Synthesis of Acylsilanes by Copper(I)‐Catalyzed Addition of Silicon Nucleophiles onto Acid Derivatives.
Authors: Cirriez Virginie , Rasson Corentin , Riant Olivier 
Published: April 2014

AbstractAdditionally, a one‐pot two‐step procedure for the synthesis of acylsilanes directly from carboxylic acids is also presented.
ChemInform Abstract: Selective Catalytic Monoreduction of Dichlorooligosilanes with Grignard Reagents.
Authors: Kanno Ken‐ichiro , Niwayama Yuka , Kyushin Soichiro 
Published: April 2014

AbstractThe monoreduction of dichlorooligosilanes and 1,2‐dimethoxysilane (VI) is achieved using Grignard reagents in the presence of a titanium catalyst.
ChemInform Abstract: Bifunctional Iminophosphorane Organocatalysts for Enantioselective Synthesis: Application to the Ketimine Nitro‐Mannich Reaction.
Authors: Nunez Marta G. , Farley Alistair J. M. , Dixon Darren J. 
Published: April 2014

AbstractThe first metal‐free catalytic enantioselective addition of nitromethane to unreactive aromatic, heteroaromatic and aliphatic ketone‐derived imines is described.
ChemInform Abstract: Synthesis of Oxazolidinylphosphine Chalcogenides (II) from Aminoethyl Vinyl Ethers (I)
Authors: Volkov P. A. , Ivanova N. I. , Gusarova N. K. , Oparina L. A. , Larina L. I. , Vysotskaya O. V. , Kolyvanov N. A. , Bagryanskaya I. Yu. , Trofimov B. A. 
Published: April 2014

Abstractvia a thermal cyclocondensation reaction
ChemInform Abstract: Organophosphorus‐Selenium Heteroatom Derivatives from Selenation of Primary/Secondary Amines and Haloalkanes/Dihaloalkanes.
Authors: Hua Guoxiong , Arachchige Kasun S. A. , Slawin Alexandra M. Z. , Woollins J. Derek 
Published: April 2014

AbstractThe reaction of compound (I) with amines leads to ammonium phenylphosphonamido‐diselenoates or phenylphosphonamido‐diselenoic diamides which react in situ with haloalkanes or dihaloalkanes to yield the title compounds.
ChemInform Abstract: Inhibitory Effect of Four Triterpenoids from Trichilia connaroides on Nitric Oxide Production in Lipopolysaccharide‐Stimulated RAW264.7 Cells.
Authors: Wang Hong‐Ying , Wang Jun‐Song , Zhang Yao , Luo Jun , Yang Ming‐Hua , Wang Xiao‐Bing , Kong Ling‐Yi 
Published: April 2014

AbstractTwo new highly rearranged trichiliton‐type limonoids, trichilitons G (I) and H (II), and two new cycloartane‐type triterpenoids (III) are isolated.
From Door‐to‐Balloon Time to Contact‐to‐Device Time: Predictors of Achieving Target Times in Patients With ST‐Elevation Myocardial Infarction
Authors: Roswell Robert O. , Greet Brian , Parikh Parin , Mignatti Andrea , Freese John , Lobach Iryna , Guo Yu , Keller Norma , Radford Martha , Bangalore Sripal 
Published: April 2014

AbstractBackgroundThe 2013 American College of Cardiology Foundation/American Heart Association ST‐segment elevation myocardial infarction (STEMI) guidelines have shifted focus from door‐to‐balloon (D2B) time to the time from first medical contact to device activation (contact‐to‐device time [C2D] ).HypothesisThis study investigates the impact of prehospital wireless electrocardiogram transmission (PHT) on reperfusion times to assess the impact of the new guidelines.MethodsFrom January 2009 to December 2012, data were collected on STEMI patients who received percutaneous coronary interventions; 245 patients were included for analysis. The primary outcome was median C2D time in the PHT group and the secondary outcome was D2B time.ResultsPrehospital wireless electrocardiogram transmission was associated with reduced C2D times vs no PHT: 80 minutes (interquartile range [IQR], 64–94) vs 96 minutes (IQR, 79—118), respectively, P < 0.0001. The median D2B time was lower in the PHT group vs the no‐PHT group: 45 minutes (IQR, 34–56) vs 63 minutes (IQR, 49–81), respectively, P < 0.0001. Multivariate analysis showed PHT to be the strongest predictor of a C2D time of <90 minutes (odds ratio: 3.73, 95% confidence interval: 1.65‐8.39, P = 0.002). Female sex was negatively predictive of achieving a C2D time <90 minutes (odds ratio: 0.23, 95% confidence interval: 0.07‐0.73, P = 0.01).ConclusionsIn STEMI patients, PHT was associated with significantly reduced C2D and D2B times and was an independent predictor of achieving a target C2D time. As centers adapt to the new guidelines emphasizing C2D time, targeting a shorter D2B time (<50 minutes) is ideal to achieve a C2D time of <90 minutes.
Intramolecular π Stacking in Cationic Iridium(III) Complexes with Phenyl‐Functionalized Cyclometalated Ligands: Synthesis, Structure, Photophysical Properties, and Theoretical Studies
Authors: Li Peng , Shan Guo‐Gang , Cao Hong‐Tao , Zhu Dong‐Xia , Su Zhong‐Min , Jitchati Rukkiat , Bryce Martin R. 
Published: April 2014

AbstractThe syntheses of two new heteroleptic cationic iridium complexes containing 2,6‐diphenylpyridine (Hdppy) and 2,4,6‐triphenylpyridine (Htppy) as the cyclometalated ligands, namely, [Ir(dppy)2phen]PF6 (1, phen = 1,10‐phenanthroline) and [Ir(tppy)2phen]PF6 (2), are described. The X‐ray crystal structure of 2 reveals a distorted octahedral geometry around the Ir center and close intramolecular face‐to‐face π–π stacking interactions between the pendant phenyl rings at the 2‐position of the cyclometalated ligands and the NN ancillary ligand. This represents a new π–π stacking mode in charged Ir complexes. Complexes 1 and 2 are green photoemitters: their photophysical and electrochemical properties are interpreted with the assistance of density functional theory (DFT) calculations. These calculations also establish that the observed intramolecular interactions cannot effectively prevent the lengthening of the Ir–N bonds of the complexes in their metal‐centered (3MC) states. Complexes 1 and 2 do not emit light in light‐emitting electrochemical cells (LECs) under conditions in which the model compound [Ir(ppy)2phen]PF6 (3) emits strongly. This is explained by degradation reactions of the 3MC state of 1 and 2 under the applied bias during LEC operation facilitated by the enhanced distortions in the geometry of the complexes. These observations have important implications for the future design of complexes for LEC applications.
Synthesis, Crystal Structures, and DNA Cleavage Activities of Manganese(II) Complexes: A Good Example of the Synergy between Metal Ions Prompting DNA Cleavage
Authors: Zhu Li‐Na , Gao Huan‐Rui , Wang Hai‐Xian , Xu Ming‐Yuan , Li Xiao‐Zeng 
Published: April 2014

AbstractThe potential synergy between metal centers makes multinuclear metal complexes promising candidates for artificial nucleases. However, few multinuclear mimics have shown higher DNA cleavage efficiencies than their mononuclear analogues. By using 1,8‐naphthalene dicarboxylic acid (1,8‐H2ndc) and 1,10‐phenanthroline (phen) ligands, one mononuclear complex [Mn(1,8‐ndc)(phen)2(H2O)]·CH3OH·2H2O (1), two dinuclear complexes [Mn(1,8‐Hndc)(phen)2]2·2ClO4·4H2O (2) and [Mn(1,8‐ndc)(phen)(H2O)2]2·CH3OH·H2O (3), and one hexanuclear complex [Mn(1,8‐ndc)(phen)(H2O)2]6·11H2O (4) were synthesized and structurally characterized by single‐crystal X‐ray analysis. Complexes 2–4 have closed‐ring structures bridged by 1,8‐ndc ligands that adopt a peculiar μ2‐η1:η1 bridging mode, which has never been reported before. Circular dichroism and fluorescence studies show that the four complexes interacted with calf thymus DNA through the intercalative binding mode, and the binding ability order is 2 > 1 > 3 > 4. All of the complexes can efficiently promote the oxidative cleavage of plasmid pBR 322 DNA in the presence of H2O2 with an efficiency order 3 > 4 > 2 > 1. The higher DNA cleavage abilities of the multinuclear complexes than the mononuclear one, combined with the fact that 3 with the shortest intramolecular Mn···Mn distance and the strongest magnetic coupling between MnII ions shows the highest DNA cleavage efficiency, confirm the great effect of the synergy between metal centers on the DNA cleavage efficiency of complexes. The four complexes also show strong concentration‐dependent cytotoxicity to human breast cancer cells.
Where diversity comes from and why it matters?
Authors: Page Scott E. 
Published: April 2014

AbstractIn this essay, I describe some of the benefits of cognitive diversity in a complex world as well as the origins of that diversity. The essay has two main parts sandwiched between a brief description of what I mean by diversity and complexity, as well as a brief discussion of whether social systems produce sufficient diversity. In the first part, I describe models that provide insight into why we see the levels of diversity that we do. These models rest on social psychological foundations but borrow ideas from economics as well as population genetics. In the second part, I describe the functional benefits of diversity. I show how diverse predictive models can make a collection of people better able to make accurate predictions, how diverse perspectives and heuristics can enable groups of problem solvers to find innovative new solutions to problems, and how diverse behaviors and representations of the world can make a society more robust. Copyright © 2014 John Wiley & Sons, Ltd.
A heterogeneous modeling method for porous media flows
Authors: Hlepas Georgette , Truster Timothy , Masud Arif 
Published: April 2014

SummaryThis paper presents a new heterogeneous multiscale modeling method for porous media flows. Physics at the global level is governed by one set of PDEs, while features in the solution that are beyond the resolution capacity of the global model are accounted for by the next refined set of governing equations. In this method, the global or coarse model is given by the Darcy equation, while the local or refined model is given by the Darcy–Stokes equation. Concurrent domain decomposition where global and local models are applied to adjacent subdomains, as well as overlapping domain decomposition where global and local models coexist on overlapping domains, is considered. An interface operator is developed for the case where global and local models commute along the common interface. For the overlapping decomposition, a residual‐based coupling technique is developed that consistently facilitates bottom‐up embedding of scale effects from the local Darcy–Stokes model into the global Darcy model. Numerical results are presented for nonoverlapping and overlapping domain decompositions for various benchmark problems. Computed results show that the hierarchically coupled models accurately account for the heterogeneity of the medium and efficiently incorporate local features into the global response. Copyright © 2014 John Wiley & Sons, Ltd.
The osteoregenerative effects of platelet‐derived growth factor BB cotransplanted with mesenchymal stem cells, loaded on freeze‐dried mineral bone block: A pilot study in dog mandible
Authors: Khojasteh Arash , Dashti Seyedeh Ghazaleh , Dehghan Mohammad Mehdi , Behnia Hossein , Abbasnia Pegah , Morad Golnaz 
Published: April 2014

AbstractDue to shortcomings associated with autogenous bone graft, the gold standard of craniofacial grafting, investigators seek alternatives that are accessible, efficient, and affordable. Accordingly, in the present pilot study, bone regeneration was induced using bone marrow‐derived mesenchymal stem cells (BMSCs) loaded onto freeze‐dried mineral bone block (FDMBB) in the presence or absence of recombinant platelet‐derived growth factor‐BB (rh PDGF‐BB). Eight weeks after the bilateral extraction of premolars of four mongrel dogs, 25 × 10 mm defects were created at both sides of the mandible. The right mandible received autogenous‐BMSC loaded on FDMBB (MSC group), whereas the left mandible received cellular blocks impregnated with rhPDGF‐BB (MSC + PDGF Group). Animals were euthanized 8 weeks after grafting. Micro‐computed tomography (micro‐CT) and histomorphometric analysis demonstrated higher levels of bone formation for the test group (10.34% ± 0.20 and 26.63% ± 3.14, respectively) when compared to the control group (8.20% ± 0.20 and 21.38% ± 5.11). The differences were not statistically significant (P > 0.05). According to the performed micro‐CT and histomorphometric analysis, adding 0.5 mg rhPDGF‐BB (0.3 mg/mL) to the combination of BMSC/FDMBB did not significantly increase bone formation in supracrestal defect in dog mandible. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1771–1778, 2014.
Fabrication of reactive poly(vinyl alcohol) membranes for prevention of bone cement leakage
Authors: Inoue Motoki , Sakane Masataka , Taguchi Tetsushi 
Published: April 2014

AbstractLeakage of bone cement into the spinal canal has been reported to cause many adverse effects. In this study, we designed an implantable balloon kyphoplasty material that avoids cement leakage through the formation of covalent bonds with the bone cement. For this purpose, glycidyl methacrylate (GMA) was used as a reactive functional group attached to the poly(vinyl alcohol) (PVA) membrane. The prepared membrane adhered to poly(methyl methacrylate) (PMMA)‐based bone cements within 10 min, which is the time required for PMMA polymerization in the bone cement. The bonding strength between the GMA–PVA membrane and the PMMA‐based bone cement was higher than that for the original PVA membrane, likely because vinyl bonds form between the surface of the GMA–PVA membrane and the bone cement. Since the GMA–PVA membrane adhered firmly to the PMMA‐based bone cement, the membrane was able to completely cover the PMMA‐based bone cement. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 102B: 1786–1791, 2014.
Early radiation‐induced changes evaluated by intravoxel incoherent motion in the major salivary glands
Authors: Marzi Simona , Forina Chiara , Marucci Laura , Giovinazzo Giuseppe , Giordano Carolina , Piludu Francesca , Landoni Valeria , Spriano Giuseppe , Vidiri Antonello 
Published: April 2014

PurposeTo investigate the potential of intravoxel incoherent motion (IVIM) MRI for early evaluation of irradiated major salivary glands.Materials and MethodsThirty‐four patients with head‐neck cancer were included in a prospective study. All patients underwent three serial IVIM‐MRI: before, half‐way through, and at the end of radiotherapy (RT). Apparent diffusion coefficient (ADC), ADClow derived in the low b‐value range, perfusion fraction f, and pure diffusion coefficient D were estimated. Pretreatment values and early changes of diffusion parameters were correlated with parotid mean dose (Dmean) and volume reduction after RT.ResultsChanges in diffusion parameters over time were all significant (P < 0.001 for ADC, ADClow, and D, P = 0.003 for f). Variations of ADC, ADClow, and f were not correlated with Dmean (P = 0.089, P = 0.252 and P = 0.884, respectively), whereas a significant relationship was found between changes in D and Dmean (r = 0.197 with CI95% = 0.004–0.375, P = 0.046). Pretreatment f and Dmean were the best independent predictors for the percentage shrinkage (P = 0.0003 and 0.0597 respectively; R2 = 0.391).ConclusionEarly changes of irradiated major salivary glands can be noninvasively evaluated by IVIM‐MRI. Perfusion‐related coefficients in conjunction with dosimetric information increase our capability to predict the change in parotid volume and hence, if further validated, guide treatment strategy in RT. J. Magn. Reson. Imaging 2015;41:974–982. © 2014 Wiley Periodicals, Inc.
Liquid‐Crystalline Elastomer Fibers Prepared in a Microfluidic Device
Authors: Fleischmann Eva‐Kristina , Forst F. Romina , Zentel Rudolf 
Published: April 2014

The preparation of thermoresponsive fibers made from a crosslinked liquid‐crystalline (LC) side‐chain polymer is presented. For this, an LC polyacrylate with side‐on attached mesogens and crosslinkable units is synthesized and processed in solution in a microfluidic co‐flowing device. Due to the high viscosity of the polymer and the reduced interfacial tension between the dispersed polymer solution and the immiscible ambient fluid, it becomes possible to produce and stabilize a liquid jet against its breaking into droplets, even at low shear rates. The polymer jet is finally stabilized in the capillary by UV‐initiated photopolymerization leading to well‐oriented, crosslinked LC fibers. If the crosslinking density in these fibers is moderate (LCEs), contractions of several 100% can be observed at the nematic–isotropic phase transition.
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Grout‐Verbindungen in Monopile‐Tragstrukturen von Offshore‐Windenergieanlagen
Authors: Lochte‐Holtgreven Stephan , Bechtel Anne 
Published: April 2014

AbstractGrout‐Verbindungen in Monopile‐Tragstrukturen von Offshore‐Windenergieanlagen sind hohen zyklischen Belastungen ausgesetzt. Basierend auf theoretischen und experimentellen Untersuchungen werden in diesem Beitrag Einflussfaktoren auf die Bemessung von Grout‐Verbindungen diskutiert. Die Diskussion der Einflussfaktoren erfolgt vor dem Hintergrund der im Jahr 2009 festgestellten vertikalen Setzungen an Grout‐Verbindungen ohne Schubrippen.Grouted joints in monopiles for offshore wind energy turbines. Grouted joints in monopile substructures are exposed to high cyclic loads. Based on theoretical and experimental investigations, this paper presents discovered reasons and discusses the design driving parameters for these grouted joints in the context of vertical settlements in grouted joints without shear keys which have become public knowledge in 2009.
Konstruktions‐ und Ausführungsmöglichkeiten von Anschlüssen bei Verbundflachdeckenträgern
Authors: Kuhlmann Ulrike , Hauf Gunter , Rieg Andreas 
Published: April 2014

AbstractIm Geschoss‐ und Industriebau bieten Slim‐Floor‐Träger aufgrund architektonischer, montagetechnischer und wirtschaftlicher Aspekte große Vorteile [1]. Die Anwendung und Bemessung dieser Verbundflachdeckensysteme ist jedoch nach derzeitigem Stand nur über allgemeine bauaufsichtliche Zulassungen geregelt, eine normative Regelung im Eurocode DIN EN 1994‐1‐1 [2] gibt es hierzu nicht. Neben den zum Teil besonderen Verbundmitteln sind als Abweichungen vom normalen Verbundträgerverhalten besonders die Verformung und die Querkraftabtragung zu nennen. Für das große Spektrum von Slim‐Floor‐Systemen sollen im nachfolgenden Beitrag Hinweise zur Querkraftabtragung und zu Anschlussmöglichkeiten gegeben werden. Konkrete Konstruktionshinweise betreffen sowohl Anschlüsse der Slim‐Floor‐Träger mit Hutprofil an Stützen als auch an Träger und Wände. Die diskutierten und hier gezeigten Anschlüsse können auf beliebige Querschnittsformen von Slim‐Floor‐Trägern übertragen werden.Construction solutions for slim‐floor beam joints. Slim‐floor beam solutions offer many advantages for the construction of multi‐storey buildings or industrial buildings regarding architectural, constructional and economical aspects. Nowadays the design of slim‐floor beam constructions is mainly ruled by national approvals. Slim‐floor beams are not really covered by Eurocode EN 1994‐1‐1 [2]. Slim‐floor constructions mainly differ from normal composite girders by the application of different shear connectors as well as deformation and shear force capacity behaviour. In the following paper the wide range of slim‐floor solutions will be presented regarding the construction solutions of joints and the behaviour of the shear loading. The joint solutions will be presented for slim‐floor girders with a hat‐profile for girder‐girder joints as well as girder‐column or girder‐wall joints. However, the presented joints can be transferred to many other slim‐floor sections.