bluuebunny/crossref_metadata_2025_split huggingface dataset:
Congenital diaphragmatic hernia treated via fetal endoscopic tracheal occlusion improves outcome in a middle-income country
Authors: Manfroi Amanda , Bernardes Lisandra S. , de Oliveira Luiza M.C. , Peres Stela V. , de Carvalho Werther B. , Tannuri Ana C.A. , da Silva Marcos M. , del Bigio Juliana Z. , de Amorim Filho Antonio G. , de Carvalho Mário Henrique Burlacchini , de Francisco Rossana Pulcineli Vieira , Carvalho Mariana A. 
Published: June 2024

Abstract

Objectives
A recent European randomized trial – Tracheal Occlusion To Accelerate Lung Growth – demonstrated that fetoscopic endoluminal tracheal occlusion (FETO) is associated with increased postnatal survival among infants with severe congenital diaphragmatic hernia (CDH). However, this differs in middle-income countries such as Brazil, where abortion is illegal and neonatal intensive care is inadequate. This study evaluated the effects of FETO on improving the survival of infants with moderate-to-severe CDH in isolated and non-isolated cases.

Methods
This retrospective cohort study selected 49 fetuses with CDH, a normal karyotype, and a lung-to-head ratio (LHR) of <1 from a single national referral center for fetal surgery in São Paulo, Brazil, between January 2016 and November 2019. FETO was performed between 26 and 29 weeks of gestation. The primary outcomes were infant survival until discharge from the neonatal intensive care unit and survival until six months of age.

Results
Forty-six women with singleton fetuses having severe CDH underwent prenatal intervention with FETO. Infant survival rates until discharge and at six months of age were both 38 %. The observed-to-expected LHR increased by 25 % after FETO in neonates who survived until discharge. Spontaneous intrauterine death occurred in four growth-restricted fetuses after FETO. Preterm birth in <37 weeks and preterm rupture of membranes in <34 weeks occurred in 56.5 % (26) and 26 % (12) cases, respectively.

Conclusions
FETO may increase neonatal survival in fetuses with severe CDH, particularly in countries with limited neonatal intensive care.
Perovskite: a key structure for a sustainable hydrogen economy
Authors: Sanson Alessandra 
Published: June 2024

Abstract
Perovskites materials, due to their peculiar electronic and ionic properties, play a key role in the development of hydrogen-based technologies. Their flexible structure enables an easy tuning of various physical-chemical characteristics, such as ionic and electronic conductivity and redox active sites concentration, fundamental for these applications. Moreover, the same structure can exhibit different properties that can synergically act to improve the performance of the material for a specific application.
A long trace of an early modern historical phenomenon: The 1903 Rákóczi pilgrimage to Constantinople
Authors: Kincses Katalin Mária 
Published: June 2024

AbstractFerenc Rákóczi II, Prince of Transylvania, the leader of the Hungarian war of independence against the Habsburgs between 1703 and 1711, was the first legend of Hungarian national independence at the turn of the century. In the early years of the 20th century, after decades of social and political struggle, the transportation of the prince's body from his original burial place in Constantinople to Hungary came within reach. Until that happened, his tomb was visited several times and for various purposes by Hungarian historians, politicians, religious leaders, and public figures – visits known as the Rákóczi pilgrimage. The most significant was the Rákóczi pilgrimage of 1903. It involved important rituals of cultic attitudes: visiting the tomb of a saint, participating in cultic ceremonies, and collecting relics. The event was one of the most important modern pilgrimages of the early 20th century, with historical roots dating back to the early modern period.
Study of the risks of radiation induced reactions in patients receiving irradiation of the pelvic organs
Authors: Korytov O. V. , Korytova L. I. , Grigorjev S. G. 
Published: June 2024

Background. The oncological incidence in the world and the Russian Federation of rectal cancer (RC), prostate cancer (PC) and cervical cancer (CC) over the past 10–15 years remains high, with overall incidence of the pelvic organs cancer up to 25 % of the total. Radiation therapy is included in the complex of therapeutic measures in 50–70 % of cancer patients. The main feature of radiation therapy of patients with malignant neoplasms is the effect on both tumor and healthy cells of surrounding tissues. The development of radiation damage to healthy tissues, expressed in radiation reactions (RR) and complications lead to a deterioration in the quality of life. Unfortunately, it is currently not possible to predict which of the patients will develop radiation injuries above grade 1 and at what time.Aim. To assess the risks of RR in patients with diagnoses of RC, prostate cancer and cervical cancer who underwent radiation therapy.Materials and methods. The study included 759 patients, including 387 CC, 175 PC, and 197 RC, who received radiation therapy from 2011 to 2019 in the medical institutions of St. Petersburg and the Leningrad region.Results. More than 30 factors that characterized patients, tumor features and concomitant therapy options were studied. Twelve of them turned out to be significant. In order to establish the main determinants (factors) associated with the risk of radiation reactions, a discriminant analysis was carried out. A formula has been created to calculate the probability of developing RR. We conducted an additional study on changing the timing of the introduction of hydrogel compositions, in which a decrease in the frequency of radiation-induced cystitis was noted.Conclusion. Discriminant analysis revealed predictors of RR in patients with RC, CC, and PC out of 30 factors studied. From the results of discriminant analysis, formulas for predicting the probability of developing acute RR in patients with diagnoses of RC, CC, and PC who received radiation therapy were derived. The change in the time of administration of hydrogel compositions before, during and after the end of radiation therapy contributed to a decrease in the occurrence of radiation-induced cystitis compared with the control (р <0.05).
Distribution Related to All Samples and Extreme Events in the ETAS Cluster
Authors: Spassiani Ilaria , Petrillo Giuseppe , Zhuang Jiancang 
Published: June 2024

Abstract
The probabilistic approach of statistical seismology plays a fundamental role in analyzing the evolution of an earthquake sequence at different scales to deliver reliable forecasts of complex earthquake phenomena. This study contributes to the field by extending previous results relative to the extreme events probability. We derive the explicit formulation of the probability of extreme events in any seismic cluster generated by the epidemic-type aftershock sequence model, as a function of time, space, and magnitude. The results give insights into understanding the distinguishing features between mainshocks and foreshocks, thus helping to shed light on earthquake prediction.
Fluids-Triggered Swarm Sequence Supported by a Nonstationary Epidemic-Like Description of Seismicity
Authors: Petrillo Giuseppe , Kumazawa Takao , Napolitano Ferdinando , Capuano Paolo , Zhuang Jiancang 
Published: June 2024

Abstract
The variation in Coulomb failure stress (CFS) plays a crucial role in either increasing or decreasing seismic activity. In cases in which the standard epidemic-type aftershock sequence (ETAS) model does not adequately fit seismicity data, the potential deviations from empirical laws are explored. These deviations may arise from stress changes imparted by aseismic transients that lead swarm-like earthquake sequences to occur. The time-dependent background rate of seismicity serves as an indicator for detecting changes in CFS or the presence of transient aseismic forcing. We investigate seismic anomalies in the slow deforming Mt. Pollino, Italy seismogenic area, where a 4-yr-long swarm-like sequence partially filled a previously hypothesized seismic gap. The primary process of this seismic swarm is still under debate. Employing a nonstationary ETAS model on a new template-matching high-resolution catalog, we suggest a slow-slip event and fluid interplay as the main aseismic forces in triggering and developing this swarm-like sequence.
Fault–Dike–Magma Interactions Inferred from Transcrustal Conical Structures under Akutan Volcano
Authors: Schulte-Pelkum Vera , Haney Matthew M. 
Published: June 2024

Abstract
Volcano monitoring and eruption forecasting require accurate characterization of transcrustal magmatic structures to place volcanic unrest in context within the system where it occurs. Structural imaging using local seismicity is limited to seismogenic depths. Here, we exploit arrivals in teleseismic receiver functions that change polarity with backazimuth to image two surfaces beneath Akutan volcano in the Aleutian arc. The two surfaces delineate an upper to midcrustal inverted conical volume that deepens and thickens away from the volcanic center, with thicknesses of 3–13 km. The top of the volume is at depths of 2–3 km below sea level at distances of ∼5–15 km from the caldera center. The bottom is at depths of 7–15 km at the same distances, and the cone’s thickness increases outward from ∼5 to ∼10 km. The signal is best fit by a volume with anisotropy with fast symmetry planes that dip outward from the center and downward increases in shear velocity at both interfaces. The upper boundary coincides with the top of Akutan’s volcanotectonic (VT) seismogenic zone, with the VT seismicity exhibiting outward dipping planar features that match the anisotropic fast plane orientation within the volume. The bottom of the anisotropic volume is below the termination depth of the majority of the VT seismicity and is therefore likely associated with the brittle–ductile transition. Long-period (LP) events associated previously with magma movement are concentrated below the anisotropic VT volume. Because of the strong spatial association with VT seismicity, we interpret the volume as consisting of concentric outward dipping faults and dikes that align the seismogenic response to stress changes from magmatic processes. Our observations map this volume independent of the present-day seismicity distribution and thus provide a spatially more complete image of the magmatic system.
Pengaruh Suhu Pengeringan Pada Alat Pengering Tipe Rak Terhadap Mutu Tepung Porang (Amorphophallus muelleri Blume)
Authors: Ifmalinda Ifmalinda , Guci Krisna , Cherie Dinah 
Published: June 2024

Abstrak. Umbi porang (Amorphopallus muelleri Blume) adalah salah satu jenis umbi-umbian yang bernilai ekonomis tinggi karena mengandung glukomanan yang kaya akan manfaat dan berpotensi diolah menjadi tepung porang. Salah satu tahpan yang sangat penting dalam produksi tepung adalah proses pengeringan. Penelitian ini bertujuan untuk mengkaji pengaruh suhu pengeringan terhadap mutu tepung porang pada proses pengeringan dengan menggunakan alat pengering tipe rak dengan sumber panas dari pembakaran gas. Penelitian ini menggunakan metode eksperimen dengan rancangan acak lengkap (RAL) satu faktor yaitu suhu pengeringan. Suhu pengeringan yang diuji adalah suhu 45 °C, 50 °C dan 55 °C. Hasil penelitian ini menunjukkan bahwa suhu pengeringan berpengaruh nyata terhadap mutu tepung porang. Mutu tepung porang terbaik diperoleh pada suhu pengeringan 55°C dengan kadar air sebesar 11,104%, kadar abu sebesar 5,816%, kadar glukomanan sebesar 17,785%, rendemen sebesar 13,444%, dan modulus kehalusan tepung sebesar 2,556. The Effect of Drying Temperature in a Tray Dryer on the Quality of Porang Flour (Amorphophallus muelleri Blume) Abstract. Amorphopallus muelleri Blume, often known as porang tuber is a type of tuber with significant commercial importance due to the presence of glucomannan which has numerous health benefits and may be converted into porang flour. The drying process is one of the most important steps in the producing flour. This study uses a tray drier with the heat energy produced from gas stove. The objective of the study is to determine the influence of drying temperature against the quality of porang flour. The study had been conducted by completely randomized design (CRD) experimental at 3 levels of drying temperatures, 45, 50, and 55°C. Results showed that the drying temperature significantly affects the quality of porang flour including yield, glucomannan content, water content, ash content, and flour fineness modulus. The optimal quality of porang flour was achieved at drying temperature of 55°C. The characteristic of porang flour were moisture content of 11.104%, ash content of 5.816%, glucomannan content of 17.785%, yield of 13.444%, and flour fineness modulus of 2,556.
Cross-sectional Study of Correlation Between Andropause and Anxiety Disorders Among Police Officers in Bali
Authors: Aprilio Sendi , Pramesemara I Gusti Ngurah , Negara I Made Oka 
Published: June 2024

Background: Andropause is a clinical and biochemical syndrome associated with increasing age characterized by a decreased testosterone level. Anxiety disorders are mental disorders that differ from normal feelings of nervousness or anxiousness and involve excessive fear or anxiety. Police officers has a high risk of experiencing andropause and anxiety disorders because of the andropause.
Objective: This research aims to determine the correlation between andropause and anxiety disorders in Bali police officers.
Methods: This research was carried out with a cross-sectional analytic design. Andropause was measured using an ADAM questionnaire. Anxiety disorder was measured using a BAI questionnaire. The sample for this research was male police officers aged between 35-58 years who worked at the Ditreskrimsus Polda Bali. The sample was determined using a purposive sampling technique. The sample for this research consisted of 50 people.
Results: The results showed that 60% of samples were positive for andropause and 62% of samples were positive for anxiety disorders. There are 52% sample that tested positive for both andropause and anxiety. There is a significant correlation between andropause and anxiety disorders with p value <0.001. Calculated Odds Ratio (OR 95% CI) between andropause and anxiety disorders was 19.5 (4.527-83.992). Police officers that experiencing andropause have a 19.5 times higher risk of experiencing anxiety disorders compared to police officers that not experiencing andropause.
Conclusion: There is a significant correlation between andropause and the occurrence of anxiety in police officers in Bali.
Longitudinal biomarker evaluation in Fabry disease patients receiving lentivirus-mediated gene therapy
Authors: Auray-Blais Christiane , Lavoie Pamela , Martineau Tristan , Rupar C. Anthony , Barber Dwayne L. , Keating Armand , Foley Ronan , Khan Aneal , West Michael L. , Medin Jeffrey A. 
Published: June 2024

Aim: In 2016, a team of Canadian researchers initiated the world’s first gene therapy clinical trial for Fabry disease. The study, aiming to determine the safety and toxicity of lentivirus α-galactosidase A transduced autologous CD34+ cells in adult males with Fabry disease (n = 5), was conducted at three Canadian centers. The objective of the present work was to evaluate a profile of Fabry disease-related biomarkers in five participants during a 5-year surveillance period, as part of the evaluation of this novel therapy.
Methods: Sixteen globotriaosylceramide (Gb3) isoforms and eight globotriaosylsphingosine (lyso-Gb3) analogues were measured by LC-MS/MS in plasma and urine at numerous time points before and after gene therapy. Plasma and peripheral blood leukocyte α-galactosidase A activity were also measured.
Results: Levels of urine and plasma lyso-Gb3 and analogues, and urine Gb3 were lower after gene therapy and while treated with enzyme replacement therapy (ERT) compared to baseline (before gene therapy) in participants treated with ERT only. Three participants chose to cease ERT treatment at some point after gene therapy. Two of these patients had lower levels of urine and plasma lyso-Gb3 and analogues compared to baseline, whereas one participant had higher levels of these biomarkers compared to baseline. An increase in urine Gb3 was observed when ERT treatment ceased after gene therapy (P < 0.05) in all three participants.
Conclusion: The evaluation of this complete glycosphingolipid biomarker profile was useful in monitoring the biochemical response to gene therapy in this cohort of five patients with Fabry disease.
Magma chamber longevity on Mars and its controls on crustal structure and composition
Authors: Chatterjee Arka , Huber Christian , III James Head , Bachmann Olivier 
Published: June 2024

Abstract

In volcanically active planetary bodies, the depths and longevity of crustal magma storage critically control eruptibility and crustal composition. A paucity of relevant observations and models has challenged our understanding of the development of crustal magma storage systems in Mars and their role in the apparent lack of evolved compositions. Here, we use numerical modelling, together with recent results from the InSight mission, to study the evolution of crustal magma chambers on Mars and conditions that promote their growth and eruptibility. We find that the Martian crust can be divided, by depth, into three major domains. For Elysium Planitia (the InSight landing site), at depths ≤15km (~1.5kbar), trapped magma pods are small, short-lived, with high diking potential, hindering the production of evolved compositions. While depths >25km (~2.5kbar) can host long-lived magma chambers, 15-25km (~2 ± 0.5kbar) marks a transition where magma chambers could grow while concurrently expelling magma. Interestingly, this narrow depth window overlaps with the depth of an intra-crustal discontinuity reported by InSight, suggesting a possible magmatic origin for the discontinuity. We further show that the crustal thermal gradient strongly controls this transition depth, indicating the possible variability of the domain depths in different terrains. Our results also support the likelihood of deep-seated magmatism beneath the seismically active Cerberus Fossae, suggesting that magmatism continues to play a major role in shaping the Martian crust.
Level of clinical competency and associated factors of nursing students in Ethiopia: systematic review and meta-analysis
Authors: workneh Moges , Kassa Molla , Mihrete Setegn , Belege Fekadeselassie , Nigussie Jemberu , Goshiy Debrnesh , Biset Gebeyaw 
Published: June 2024

Abstract

Background:Assessing the clinical level of competency in nursing students is crucial as it represents the ultimate goal of nursing education. Poor competency result in low performance and can be influenced by various factors. Thus, the aim of this study was to identify level of clinical competency and associated factors of nursing students in Ethiopia
Methods:systematic review and meta-analysis was employed. Searching strategy was conducted from January up to march 2024 from Web of Science, PubMed and Google Scholar. The quality of studies was assessed using PRISMA checklist. A meta-analysis was performed using R Studio with the meta package Version 1.4.1106.
Results: in total, 145 studies were identified through database search, and only 7 studies were included in the meta-analysis representing 1937 nursing students. The pooled effect size of clinical competency of nursing students was 28%. Three factors were found to be associated with clinical competency: a positive clinical learning environment, student confidence in performing procedures, and effective staff-student interaction. The effect sizes of these factors were 6.30, 2.23, and 7.76, respectively.
Conclusion and recommendation: The clinical competency of nursing students was 28%, and it was associated with clinical learning environment, student confidence in performing procedures, and staff-student interaction. Nursing education programs should focus on enhancing students' competency levels by addressing specific factors.
(PROSPERO) International prospective register of systematic reviews: CRD42022367057
Integrative Neuro-social cognitive Strategy Programme for Instilling REcovery (INSPIRE): a Community-Based Cognitive Remediation Trial-Study Procotol
Authors: Tan Bhing-Leet , Tan Noel , Koh Vanessa , Poh Lin , Medalia Alice 
Published: June 2024

Abstract

Background
Adults with schizophrenia experience a range of neurocognitive problems that affect their daily functioning. Evidence for the efficacy of cognitive remediation in schizophrenia has been established, but its implementation in under-resourced community-based settings is less well-studied. In recent years, interventions have also focused on the strategy-learning approach in favor of drill-and-practice. Moreover, there is an increasing recognition to address social cognition and negative symptoms alongside neurocognition.
This study attempts to carry out cognitive remediation in a community mental health setting. The Neuropsychological and Educational Approach to Remediation (NEAR) is used as the cognitive remediation intervention. Neurocognitive and social cognitive games will be introduced during the computer-assisted cognitive exercises sessions. In addition, the instructional technique will foster the use of metacognition and cognitive strategies. Moreover, metamotivation training will be the focus of some bridging sessions to enhance motivation to engage in goal-directed learning behaviors.
The aims of the study are to 1) investigate the effects of cognitive remediation on neurocognition, social cognition and functional outcomes of participants with schizophrenia/schizoaffective disorders in community mental health settings; and 2) explore the mediators for change (eg: metamotivation, metacognition and negative symptoms) in cognitive performance and functional outcomes.
Methods
This randomized controlled trial will be conducted in three Singapore Anglican Community Services (SACS) centers, where standard psychiatric rehabilitation is delivered. Participants who are randomized to the experimental arm will receive cognitive remediation and psychiatric rehabilitation, while those randomized to the control arm will receive standard psychiatric rehabilitation only. Cognitive remediation is carried out three times a week for 12 weeks. It consists of computer-assisted cognitive exercises, as well as bridging groups to aid transfer of learning to daily living. Baseline, post-intervention and eight-week follow-up measurements will be collected. Group by time differences in cognitive performance, negative symptoms, metamotivation, metacognition, functioning and recovery will be analyzed across the three time points. Mediators for improvement in cognitive performance and functioning will also be explored.
Discussion
Findings of this research will add to the body of knowledge about the key therapeutic ingredients within a strategy-based cognitive remediation program and improve its implementation within under-resourced community settings.
Trial registration: this study has been registered with ClinicalTrials.gov (ID: NCT06286202). Date of registration: 29 February 2024. Date of last update: 21 May 2024.