bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of pH on the resistance of resting‐ and active anammox bacteria to NO2− inhibition
Authors: Carvajal‐Arroyo José M. , Puyol Daniel , Li Guangbin , Sierra‐Álvarez Reyes , Field Jim A. 
Published: April 2014

ABSTRACTThe anaerobic oxidation of ammonium (anammox) uses nitrite as terminal electron acceptor. The nitrite can cause inhibition to the bacteria that catalyze the anammox reaction. The literature shows a great divergence on the levels of NO2− causing inhibition. Moreover, the conditions influencing the resistance of anammox bacteria to NO2− inhibitory effect are not well understood. This work investigated the effect of the pH and the concentration of nitrite on the activity and metabolism of anammox granular sludge under different physiological conditions. Batch activity tests in a range of pH values were carried out in which either actively metabolizing cells or resting cells were exposed to nitrite in the presence or absence of the electron donating substrate ammonium, respectively. The response of the bacteria was evaluated by analyzing the specific anammox activity, the accumulation of nitric oxide, and the evolution of the ATP content in the biomass. Additionally, the effect of the pH on the tolerance of the biomass to single substrate feeding interruptions was evaluated in continuous anammox bioreactors. The results show that the influence of the pH on the NO2− inhibition of anammox bacteria is greater under non‐metabolizing conditions than during active metabolism. The exposure of resting cells to NO2− (100 mg N L−1) at pH values below 7.2 caused complete inhibition of the anammox activity. The inhibition was accompanied by accumulation of the intermediate, nitric oxide, in the gas phase. In contrast, just mild inhibition was observed for resting cells exposed to the same NO2− concentration at pH values higher than 7.5 or any of the pH values tested in assays with actively metabolizing cells. ATP initially increased and subsequently decreased in time after resting cells were exposed to NO2− suggesting an active response of the cells to nitrite stress. Furthermore, bioreactors operated at pH lower than 6.8 had greater sensitivity to NO2− during an ammonium feed interruption than a bioreactor operated at pH 7.1. The results suggest that the ability of resting cells to tolerate NO2− inhibition is seriously impeded at mildly acidic pH values; whereas actively metabolizing biomass is resistant to NO2− toxicity over a wide range of pH values. Biotechnol. Bioeng. 2014;111: 1949–1956. © 2014 Wiley Periodicals, Inc.
Monocyte‐based microrobot with chemotactic motility for tumor theragnosis
Authors: Park Sung Jun , Lee Yeonkyung , Choi Young Jin , Cho Sunghoon , Jung Han‐Earl , Zheng Shaohui , Park Bang Ju , Ko Seong Young , Park Jong‐Oh , Park Sukho 
Published: April 2014

ABSTRACTBiocompatibility, sensing, and self‐actuation are very important features for a therapeutic biomedical microrobot. As a new concept for tumor theragnosis, this paper proposes a monocyte‐based microrobots, which are combining the phagocytosis and engulfment activities containing human acute monocytic leukemia cell line (THP‐1) with various sized polystyrene microbeads are engulfed instead of a therapeutic drug. For the validation of the blood vessel barrier‐penetrating activity of the monocyte‐based microrobot, we fabricate a new cell migration assay with monolayer‐cultured endothelial cell (HUVEC), similar with the blood vessels. We perform the penetrating chemotactic motility of the monocyte‐based microrobot using various types of the chemo‐attractants, such as monocyte chemotactic protein (MCP)‐1, human breast cancer cell lines (MCF7)‐cell lysates, and ‐contained alginate spheroids. The monocyte‐based microrobot show chemotactic transmigrating motilities similar with what an actual monocyte does. This new paradigm of a monocyte‐based microrobot having various useful properties such as biocompatibility, sensing, and self‐actuation can become the basis of a biomedical microrobot using monocytes for diagnosis and therapy of various diseases. Biotechnol. Bioeng. 2014;111: 2132–2138. © 2014 Wiley Periodicals, Inc.
Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp
Authors: Luo Xiao‐Jing , Kong Xu‐Dong , Zhao Jian , Chen Qi , Zhou Jiahai , Xu Jian‐He 
Published: April 2014

ABSTRACTOPHC2 is a thermostable organophosphate (OP) hydrolase in the β‐lactamase superfamily. OPs are highly toxic synthetic chemicals with no natural analogs. How did OPHC2 acquire phosphotriesterase (PTE) activity remained unclear. In this study, an OPHC2 analogue, PoOPH was discovered from Pseudomonas oleovorans exhibiting high lactonase and esterase activities and latent PTE activity. Sequence analysis revealed conserved His250 and Ile263 and site‐directed mutagenesis at these crucial residues enhanced PTE activity. The best variant PoOPHM2 carrying H250I/I263W mutations displayed 6,962‐ and 106‐fold improvements in catalytic efficiency for methyl‐parathion and ethyl‐paraoxon degradation, whereas the original lactonase and esterase activities decreased dramatically. A 1.4 × 107‐fold of specificity inversion was achieved by only two residue substitutions. Significantly, thermostability of the variants was not compromised. Crystal structure of PoOPHM2 was determined at 2.25 Å resolution and docking studies suggested that the two residues in the binding pocket determine substrate recognition. Lastly, new organophosphorus hydrolases (OPHs) were discovered using simple double mutations. Among them, PpOPHM2 from Pseudomonas putida emerged as a new promising OPH with very high activity (41.0 U mg−1) toward methyl‐parathion. Our results offer a first scrutiny to PTE activity evolution of OPHs in β‐lactamase superfamily and provide efficient and robust enzymes for OP detoxification. Biotechnol. Bioeng. 2014;111: 1920–1930. © 2014 Wiley Periodicals, Inc.
A versatile approach to the generation of fluid supported lipid bilayers and its applications
Authors: Mashaghi Samaneh , van Oijen Antoine M. 
Published: April 2014

ABSTRACTEstablishing supported lipid bilayers with biologically relevant composition, including transmembrane proteins and various classes of lipids, presents a significant challenge. We describe a generic and facile approach to the production of fluid polymer‐supported lipid bilayers that allows for the incorporation of a wide variety of lipids and transmembrane proteins. The method is based on the formation of a polymer brush displaying lipid groups, followed by spin‐coating of membrane lipids. Subsequentially, transmembrane proteins are incorporated by the fusion of proteoliposomes with the bilayer. Several applications, including the incorporation and single‐molecule tracking of transmembrane proteins in a bilayer and the visualization of the fusion of individual, membrane‐enveloped viruses with a supported membrane, are demonstrated. Our results suggest that the membrane properties are consistent with those found in physiologically relevant conditions and underscore the wide applicability of our approach to synthetic biology, lab‐on‐a‐chip applications, biophysical and pharmaceutical studies. Biotechnol. Bioeng. 2014;111: 2076–2081. © 2014 Wiley Periodicals, Inc.
Model‐based cell number quantification using online single‐oxygen sensor data for tissue engineering perfusion bioreactors
Authors: Lambrechts T. , Papantoniou I. , Sonnaert M. , Schrooten J. , Aerts J.‐M. 
Published: April 2014

ABSTRACTOnline and non‐invasive quantification of critical tissue engineering (TE) construct quality attributes in TE bioreactors is indispensable for the cost‐effective up‐scaling and automation of cellular construct manufacturing. However, appropriate monitoring techniques for cellular constructs in bioreactors are still lacking. This study presents a generic and robust approach to determine cell number and metabolic activity of cell‐based TE constructs in perfusion bioreactors based on single oxygen sensor data in dynamic perfusion conditions. A data‐based mechanistic modeling technique was used that is able to correlate the number of cells within the scaffold (R2 = 0.80) and the metabolic activity of the cells (R2 = 0.82) to the dynamics of the oxygen response to step changes in the perfusion rate. This generic non‐destructive measurement technique is effective for a large range of cells, from as low as 1.0 × 105 cells to potentially multiple millions of cells, and can open‐up new possibilities for effective bioprocess monitoring. Biotechnol. Bioeng. 2014;111: 1982–1992. © 2014 Wiley Periodicals, Inc.
ChemInform Abstract: Improvement of the Energy Transfer from Ca3SnSi2O9 Host to Rare‐Earth Ions with the Assistance of Oxygen Vacancies.
Authors: Yu Xue , Wang Ting , Xu Xuhui , Jiang Tingming , Yu Hongling , Jiao Qing , Zhou Dacheng , Qiu Jianbei 
Published: April 2014

AbstractEu3+‐doped Ca3SnSi2O9 is prepared via solid state synthesis using stoichiometric mixtures of CaCO3, CaF2, SnO2, SiO2, Eu2O3, and Dy2O3 with small amounts of H3BO3 as flux (1400 °C, 4 h, ambient atmosphere).
ChemInform Abstract: 2‐Dimensional Transition Metal Dichalcogenides with Tunable Direct Band Gaps: MoS2(1‐x)Se2xMonolayers.
Authors: Bartels Ludwig , et al. et al. 
Published: April 2014

AbstractSingle‐layer MoS2(1‐x)Se2x films with different S/Se ratios are deposited on Si(110) wafers covered by a 300 nm SiO2 layer from mixtures of Ph‐SH dissolved in THF, Ph‐Se‐Se‐Ph, and MoO3 (650—700 °C).
ChemInform Abstract: Vermiculite as a Natural Silicate Crystal for Hydrogen Generation from Photocatalytic Splitting of Water under Visible Light.
Authors: Zhang Jian , Liu Tianyu , Chen Rui , Liu Xiaoheng 
Published: April 2014

AbstractVermiculite, (Mg,Fe,Al)3(Si,Al)4O10 (OH)2·4H2O, a low cost nanosized silicate clay mineral with paper‐like morphology, is used for H2O splitting experiments under visible light in the absence of any noble metal.
ChemInform Abstract: Synthesis and Characterization of Novel Barium Iron Phosphates: Insight into New Structure Types Tailored by Hydrogen Atoms.
Authors: Sun Li‐Zhi , Sun Wei , Ren Wei‐Jian , Zhang Jia‐Ying , Huang Ya‐Xi , Sun Zhi‐Mei , Pan Yuanming , Mi Jin‐Xiao 
Published: April 2014

AbstractSingle crystals of Ba2Fe2[H(PO3OH)2] [H(P2O7)2] (I) are prepared by reaction of Ba(NO3)2, FeCl2·4H2O, and 85% H3PO4 in the molar ratio of Ba:Fe = 1:1 without addition of any water (autoclave, 240 °C, 3 d).
ChemInform Abstract: Self‐Assembly and Structural Transformations of High‐Nuclearity Palladium‐Rich Polyoxometalates.
Authors: Cameron Jamie M. , Gao Jing , Long De‐Liang , Cronin Leroy 
Published: April 2014

AbstractCompounds (IV), (V), and (VII) crystallize in the triclinic space group P$\bar 1$ with Z = 1, 2, and 2, respectively (single crystal XRD).
ChemInform Abstract: DoE (Design of Experiments) Assisted Allylic Hydroxylation of Enones Catalyzed by a Copper—Aluminum Mixed Oxide.
Authors: Garcia‐Cabeza Ana Leticia , Marin‐Barrios Ruben , Azarken Redouan , Moreno‐Dorado F. Javier , Ortega Maria J. , Vidal Hilario , Gatica Jose M. , Massanet Guillermo M. , Guerra Francisco M. 
Published: April 2014

AbstractThe regio‐ and stereoselective hydroxylation of α,β‐ or α,β,γ,δ‐ unsaturated ketones with air in the presence of KOtBu is investigated.
ChemInform Abstract: Alkene Oxyalkylation Enabled by Merging Rhenium Catalysis with Hypervalent Iodine(III) Reagents via Decarboxylation.
Authors: Wang Yin , Zhang Lei , Yang Yunhui , Zhang Ping , Du Zhenting , Wang Congyang 
Published: April 2014

AbstractThe first rhenium‐catalyzed oxyalkylation of alkenes is described using hypervalent iodine(III) reagents.
ChemInform Abstract: Microwave‐Assisted Efficient Synthesis of 2‐Hydroxydeoxybenzoins from the Alkali Degradation of Readily Prepared 3‐Aryl‐4‐hydroxycoumarins in Water.
Authors: Zhou Zhong‐Zhen , Yan Guang‐Hua , Chen Wen‐Hua , Yang Xue‐Mei 
Published: April 2014

AbstractAn efficient microwave‐assisted synthesis of 2‐hydroxydeoxybenzoins of type (III) is described, which are formed from the alkali degradation of 3‐aryl‐4‐hydroxycoumarins (II) in water.
ChemInform Abstract: Catalytic Asymmetric Hydrogenation of α‐CF3‐ or β‐CF3‐Substituted Acrylic Acids Using Rhodium(I) Complexes with a Combination of Chiral and Achiral Ligands.
Authors: Dong Kaiwu , Li Yang , Wang Zheng , Ding Kuiling 
Published: April 2014

AbstractThe products can be transformed to fluorinated natural compounds, e.g. dehydrocurcumene (VII) and tumerone (VIII).
ChemInform Abstract: Rapid Access to Spirocyclic Oxindole Alkaloids: Application of the Asymmetric Palladium‐Catalyzed [3 + 2] Trimethylenemethane Cycloaddition.
Authors: Trost Barry M. , Bringley Dustin A. , Zhang Ting , Cramer Nicolai 
Published: April 2014

AbstractThe title reaction provides a synthesis of marcofortines, which are potent anthelmintic active metabolites.
ChemInform Abstract: Highly Enantioselective Bromocyclization of Tryptamines and Its Application in the Synthesis of (—)‐Chimonanthine.
Authors: Xie Weiqing , Jiang Guangde , Liu Huan , Hu Jiadong , Pan Xixian , Zhang Hui , Wan Xiaolong , Lai Yisheng , Ma Dawei 
Published: April 2014

AbstractA highly enantioselective bromocyclization of tryptamine derivatives is developed using a DABCO‐derived bromine complex as bromide source and 8H‐(R)‐TRIP as chiral ligand.
ChemInform Abstract: Green and Highly Efficient One‐Pot Synthesis of Some New Bis Thiazolidinones
Authors: Mobinikhaledi Akbar , Amiri Alireza Khajeh 
Published: April 2014

Abstractvia simple condensation of an appropriate dialdehyde with N,N′‐diarylthioureas and chloroacetyl chloride in eutectic salts as promoter and solvent
ChemInform Abstract: Synthesis of Tricyclic Fused Coumarin Sulfonates and Their Inhibitory Effects on LPS‐Induced Nitric Oxide and PGE2 Productions in RAW 264.7 Macrophages.
Authors: Jang Hyeon‐Lok , El‐Gamal Mohammed I. , Choi Hye‐Eun , Choi Ho‐Yeong , Lee Kyung‐Tae , Oh Chang‐Hyun 
Published: April 2014

AbstractAmong all the sulfonates synthesized, compound (VIIe) is found to exhibit the highest inhibitory activities on both NO and PGE2 productions in LPS‐induced RAW 264.7 macrophages with low cytotoxicity.
ChemInform Abstract: Ligand‐Free, Copper‐Catalyzed Ullmann‐Type C—N Coupling: Regioselective Synthesis of Azole‐Substituted Imidazo[1,2‐a]pyridines.
Authors: Kaswan Pinku , Pericherla Kasiviswanadharaju , Kumar Anil 
Published: April 2014

AbstractA facile procedure for the coupling of imidazopyridines with various azoles or in situ generated 1,2,3‐triazoles to furnish the corresponding azole‐substituted derivatives is developed.
ChemInform Abstract: Stepwise Synthesis of 2‐Amino‐3‐vinylindolizines Using a Mixture of N‐Allyl‐2‐halopyridinium Halides and CH Acid Derived from Acetonitrile.
Authors: Tverdokhleb N. M. , Khoroshilov G. E. 
Published: April 2014

AbstractA simple method for the synthesis of 2‐amino‐3‐vinylindolizines via Thorpe cyclization as key step is developed.
ChemInform Abstract: Synthesis of Some Dihydropyrimidine‐Based Compounds Bearing Pyrazoline Moiety and Evaluation of Their Antiproliferative Activity.
Authors: Awadallah Fadi M. , Piazza Gary A. , Gary Bernard D. , Keeton Adam B. , Canzoneri Joshua C. 
Published: April 2014

AbstractTitle compound (III) (16 examples) are screened for their antiproliferative activity against A 549 (lung), HT 29 (colon), MCF 7, and MDA‐MB 231 (breast) cell lines.
ChemInform Abstract: Efficient Synthesis of Quinazoline‐2,4(1H,3H)‐diones from CO2 Using Ionic Liquids as a Dual Solvent—Catalyst at Atmospheric Pressure.
Authors: Lu Wenjing , Ma Jun , Hu Jiayin , Song Jinliang , Zhang Zhaofu , Yang Guanying , Han Buxing 
Published: April 2014

AbstractThe dual solvent‐catalyst [bmim]OAc can be reused at least five times without an observable decrease in catalytic activity.
ChemInform Abstract: Two New Diterpenoids from the Beibu Gulf Gorgonian Anthogorgia caerulea.
Authors: Gao Cheng‐Hai , He Bi‐Juan , Chen Yin‐Ning , Ke Ke , Lin Lin , Long Bin , Huang Ri‐Ming 
Published: April 2014

AbstractTwo new diterpenoids, anthogonoid A (I) and antsimplexin A (II), are isolated together with the structurally related and already known klysimplexin G.
ChemInform Abstract: Rare Bisindole Alkaloids from the Amazonian Tree Raputia simulans.
Authors: Vougogiannopoulou Konstantina , Travasarou Aikaterini , Fokialakis Nikolas , Skaltsounis Alexios L. 
Published: April 2014

AbstractThree new alkaloids, caulindoles E (I), F (IIa) and G (IIb), are isolated and their relative configurations are assigned.
ChemInform Abstract: A Highly Diastereoselective Oxa‐Pictet‐Spengler Approach to (+)‐Astropaquinone B and (+)‐Astropaquinone C and the Formation of Astropaquinone B Dimer.
Authors: Fernandes Rodney A. , Mulay Sandip V. 
Published: April 2014

AbstractAstropaquinone B (IV) is accompanied by minor amounts of its dimer (not shown).
ChemInform Abstract: Phase‐Pure Crystalline Zinc Phosphide Nanoparticles: Synthetic Approaches and Characterization.
Authors: Mobarok Md Hosnay , Luber Erik J. , Bernard Guy M. , Peng Li , Wasylishen Roderick E. , Buriak Jillian M. 
Published: April 2014

AbstractPhase‐pure and crystalline Zn3P2 nanoparticles (≈3—15 nm) are prepared by two different solution‐phase strategies using precipitation from a 1‐octadecene solution of P(octyl)3 (TOP) and ZnMe2 (348 °C, 2 h) followed by flocculation of nanoparticles with PrOH.
ChemInform Abstract: Multifunctional Polymer—Metal Nanocomposites via Direct Chemical Reduction by Conjugated Polymers
Authors: Xu Ping , Han Xijiang , Zhang Bin , Du Yunchen , Wang Hsing‐Lin 
Published: April 2014

AbstractReview: syntheses and application of multifunctional conjugated polymer — nobel metal nanocomposites in sensing, catalysis, and electronic devices; 50 refs.
Enantioselective Acute Toxicity Effects and Bioaccumulation of Furalaxyl in the Earthworm (Eisenia foetida)
Authors: Qin Fang , Gao Yongxin , Guo Baoyuan , Xu Peng , Li Jianzhong , Wang Huili 
Published: April 2014

ABSTRACTThe enantioselectivities of individual enantiomers of furalaxyl in acute toxicity and bioaccumulation in the earthworm (Eisenia foetida) were studied. The acute toxicity was tested by filter paper contact test. After 48 h of exposure, the calculated LC50 values of the R‐form, rac‐form, and S‐form were 2.27, 2.08, and 1.22 µg cm‐2, respectively. After 72 h of exposure, the calculated LC50 values were 1.90, 1.54, and 1.00 µg cm‐2, respectively. Therefore, the acute toxicity of furalaxyl enantiomers was enantioselective. During the bioaccumulation experiment, the enantiomer fraction of furalaxyl in earthworm tissue was observed to deviate from 0.50 and maintained a range of 0.55–0.60; in other words, the bioaccumulation of furalaxyl was enantioselective in earthworm tissue with a preferential accumulation of S‐furalaxyl. The uptake kinetic of furalaxyl enantiomers fitted the first‐order kinetics well and the calculated kinetic parameters were consistent with the low accumulation efficiency. Chirality 26:307–312, 2014. © 2014 Wiley Periodicals, Inc.
Epitaxial germanium deposited by MOVPE on InGaAs quantum dot stressors grown by MBE
Authors: Bosi M. , Attolini G. , Frigeri P. , Nasi L. , Rossi F. , Seravalli L. , Trevisi G. 
Published: April 2014

Tensile strained Ge is considered as an enabling material for the integration of light emitting sources on Si because it shows unique indirect to direct bandgap transition and very high carrier mobilities (> 10.000 cm2/Vs). In the framework of this goal we aim to realize tensile germanium on In(Ga)As quantum dots (QD) stressors grown on GaAs and in this paper we focus on the study of deposition at different temperatures of Ge layers by Metal Organic Vapor Phase Epitaxy (MOVPE) on QD grown by Molecular Beam Epitaxy (MBE). The structures were characterized by Photoluminescence (PL) and Atomic Force Microscopy (AFM) before and after Ge epitaxy. Cross sectional TEM analysis shows that the Ge overlayer is epitaxially grown on the InGaAs/GaAs QD underlayer, with the same orientation. No structural defects are observed in the whole structures. Intermixing and In desorption occur at higher deposition temperature.
Thermoset Coatings from Epoxidized Sucrose Soyate and Blocked, Bio‐Based Dicarboxylic Acids
Authors: Kovash Curtiss S. , Pavlacky Erin , Selvakumar Sermadurai , Sibi Mukund P. , Webster Dean C. 
Published: April 2014

AbstractA new 100 % bio‐based thermosetting coating system was developed from epoxidized sucrose soyate crosslinked with blocked bio‐based dicarboxylic acids. A solvent‐free, green method was used to block the carboxylic acid groups and render the acids miscible with the epoxy resin. The thermal reversibility of this blocking allowed for the formulation of epoxy‐acid thermoset coatings that are 100 % bio‐based. This was possible due to the volatility of the vinyl ethers under curing conditions. These systems have good adhesion to metal substrates and perform well under chemical and physical stress. Additionally, the hardness of the coating system is dependent on the chain length of the diacid used, making it tunable.
Left ventricular systolic dysfunction in outpatients with peripheral atherosclerotic vascular disease: prevalence and association with location of arterial disease
Authors: Hedberg Pär , Hammar Charlotta , Selmeryd Jonas , Viklund Josefin , Leppert Jerzy , Hellberg Anders , Henriksen Egil 
Published: April 2014

AimsWe aimed to determine the prevalence of left ventricular systolic dysfunction (LVSD) in outpatients with peripheral atherosclerotic vascular disease (PAVD). Further, the associations of stenotic internal carotid artery disease (SICAD) and lower extremity artery disease (LEAD) with LVSD were evaluated.Methods and resultsIn the Peripheral Artery Disease in Västmanland study, consecutive outpatients with ultrasonographically identified mild to severe stenosis in the internal carotid artery or symptoms of claudication combined with either ankle brachial index of ≤0.90 or ultrasonographic occlusive findings were included (n = 437). Population‐based control subjects were matched to the patients (n = 395). LVSD was defined as echocardiographically determined left ventricular ejection fraction (LVEF) <55%, and moderate or greater LVSD was defined as LVEF <45%. The prevalence of LVSD was significantly greater in patients than in controls (13.7% vs. 6.1%, P < 0.001). The prevalence of moderate or greater LVSD in participants not on treatment with a combination of angiotensin‐converting enzyme inhibitor and beta‐blocker was 2.3% in patients and 1.3% in controls (P = 0.31). When LEAD and SICAD were analysed together, adjusted for potential confounders, SICAD [odds ratio (OR) 2.54, 95% confidence interval (CI) 1.03–6.32], but not LEAD (OR 1.59, 95% CI 0.80–3.18), was independently associated with LVSD.ConclusionsIn outpatients with PAVD, we found a 13.7% prevalence of LVSD. However, the prevalence of at least moderate LVSD in patients not on treatment with angiotensin‐converting enzyme inhibitor and a beta‐blocker was only 2.3% and not significantly different from controls. Stenotic artery disease in the internal carotid artery, but not in the lower extremities, was independently associated with LVSD.
A Polar 18F‐Labeled Amino Acid Derivative for Click Labeling of Biomolecules
Authors: Schieferstein Hanno , Ross Tobias L. 
Published: April 2014

AbstractThis work describes the synthesis and 18F‐labeling of an amino acid based prosthetic group that is able to participate in copper(I)‐catalyzed cycloadditions. The prosthetic group can be used for 18F labeling of biomolecules under mild conditions. The synthesis started with L‐serine methyl ester, which was derivatized by introducing an alkyne moiety and a leaving group for 18F labeling. Subsequently, 18F labeling as well as deprotection conditions were screened, which resulted in an overall radiochemical yield (RCY) of around 28 %. Furthermore, the 18F‐labeled prosthetic group was treated with an azido cyclic Arg‐Gly‐Asp (cRGD) peptide as a model system in very high RCY of 98 %.