bluuebunny/crossref_metadata_2025_split huggingface dataset:
The potency-ratio of ciprofol and propofol under procedural sedation and anesthesia for outpatient hysteroscopy during cervical dilation:A study using up-and-down sequential allocation method
Authors: Jin Lin , Li Hua , Chen Xiao-ping , Sun Li-hong , Zhang Yu , Cheng Xin-zhong , Wang Jin-zhong , Qian Xiao-wei 
Published: June 2024

Abstract

Background
Ciprofol(HSK3486) is a novel 2,6-disubstituted phenol derivate, a short-acting intravenous sedative, which has similar efficacy characteristics as propofol with less incidence of side effect. Both ciprofol and propofol are often used in outpatient hysteroscopic surgery for sedation. However, the relative potency of these two drugs has not been fully determined in this context.
Methods
The effective dose in 50% of subjects(ED50) value for ciprofol and propofol were calculated by Up-and-Down Sequential Allocation Method. A total of 60 parturients undergoing daytime hysteroscopy were randomly divided into two groups, which were intravenously injected with ciprofol at an initial dose of 0.4mg/kg (group C) or propofol at an initial dose of 2mg/kg (group P) at 2 min after intravenous injection of sufentanil 0.15ug/kg. A successful response is defined as the absence of patient movement in the case of cervical dilation. Conversely, the presence of patient movement is defined as failure. After successful or failed responses, each follow-up patient in the corresponding group was reduced or increased with propofol 0.5mg/kg or ciprofol 0.1mg/kg, respectively.
Results
The estimated ED50 value for ciprofol and propofol in restraining reaction of hysteroscopy dilatation was 0.444 mg/kg (95% CI, 0.385-0.503mg/kg) and 1.985 mg/kg (95% CI, 1.801–2.170 mg/kg), respectively. The incidence of respiratory depression, hypoxemia and injection pain in ciprofol was significantly lower than those in propofol(P < 0.05).
Conclusion
The ED50 of ciprofol and propofol in preventing hysteroscopy dilatation reaction was 0.444 mg/kg (95% CI, 0.385-0.503mg/kg) and1.985 mg/kg (95% CI, 1.801–2.170 mg/kg) for outpatient hysteroscopy. The potency-ratio of ciprofol and propofol observed in our study was 1.0:4.5(95%CI,1:3.9-1:5.1).
Trial registration
The study was approved by the Ethical Committee of Women’s Hospital, Zhejiang University School of Medicine (Hangzhou, China) (No. IRB-20220157-R) and was registered at the Chinese Clinical Trials.gov (NO. ChiCTR2200065954) before patient enrollment. All participants signed an informed consent form.
Trial registration
The study was registered at Chinese Clinical Trial Registry http://www.chictr.org.cn/ (Registration date:19/11/22; Trial ID: ChiCTR2200065954).
Correlation Of E-cadherin, Vimentin, CD206, PD-1, PD-L1 Expression With Clinicopathological Factors And Prognosis In Oral Squamous Cell Carcinoma
Authors: Lai Zheng-yi , Ma JIE , Yin Jia-yi , Zhu Xiu-an , Xu Qing , Zhou Jing-ping , Tao De-tao 
Published: June 2024

Abstract

Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the head and neck. The current treatment principle is based on radical surgery, supplemented by radiotherapy and chemotherapy. However, the 5-year survival rate of patients is still around 50%. Therefore, further research on the molecular mechanism of OSCC development is needed to find out more effective treatment methods. In this study, the expression of E-cadherin, vimentin, CD206, PD-1 and PD-L1 in pathological sections of 45 patients with oral squamous cell carcinoma was quantified by immunohistochemistry. The results showed that the expression levels of vimentin, CD206 and PD-L1 were all significantly different from overall survival. At the same time, COX multivariate analysis showed that CD206, the marker of M2 macrophages,was an independent risk factor for poor prognosis in OSCC. Moreover, correlation analysis showed that the expression of E-cadherin was negatively correlated with the expression levels of vimentin, CD206 and PD-L1. The expression of vimentin was positively correlated with PD-1 and PD-L1. Therefore, the statistical data of immunohistochemical experiments in this study first showed that M2 macrophage was an independent risk factor for poor prognosis in OSCC, and was also closely related to poor overall survival. Second, it may affect the occurrence and development of OSCC tumors by inducing the occurrence of EMT in OSCC tumor cells. Third, PD-L1 has an adverse effect on the prognosis of OSCC, and it is significantly correlated with the expression levels of CD206, E-cad and vimentin. However, whether the PD-1/PD-L1 pathway can affect the occurrence and development of OSCC through M2 macrophages still needs to be further studied.
The effects of Thymus capitatus essential oil topical application on milk quality: a systems biology approach
Authors: Nehme Ralph , Gini Chiara , Vanbergue Elise , Even Sergine , Biscarini Filippo , Andrés Sonia , Rault Lucie , Noel Faustine , Hardit Valerie , Bouhallab Said , Pereira David , Ksouri Riadh , Roussel Philippe , López Secundino , Cremonesi Paola , Castiglioni Bianca , Caruso Donatella , Faré Fiorenza , Fontana Manuela , Ceciliani Fabrizio , Abdennebi-Najar Latifa 
Published: June 2024

Abstract

Essential oils (EO) are known for their antibacterial and anti-inflammatory properties and can be used as an alternative to reduce the reliance on antimicrobials in dairy cattle. While many studies have explored the beneficial properties of EO in vitro, their effects on milk quality and milk microbiota, when applied directly to the udder skin, remain relatively unknown. This study aimed to investigate the impact of Thymus capitatus EO (TCEO) on milk microbiota, lipidomic profile and inflammatory biomarkers in dairy cows at the end of the lactation period and udder skin microbiota. Sixteen quarters from 12 Holstein cows were selected, and TCEO was topically applied to the udder skin twice a day for seven days. Milk was collected aseptically at days 0, 7, 21, and 28 before morning farm milking. The results showed no significant changes in microbiota composition after the EO treatment. TCEO had a limited impact on the milk lipidome, primarily affecting diacylglycerol components at T21. The treatment did not affect inflammatory biomarkers, milk sensory properties, and quality. Our study demonstrates that applying 10% TCEO on cow's quarters does not significantly alter milk quality or microbiota composition in milk and skin, suggesting its safe use in dairy cows.
Association of dietary intake of theobromine with periodontitis: NHANES 2009-2014
Authors: Zhou Ya-Shi , Cai Song , Li Si-Yu , Song Ju-Kun , Peng Ju-Xiang 
Published: June 2024

Abstract

Background:
Theobromine intake usually comes from coffee, tea, and cocoa foods. Related studies have shown that theobromine is a bioactive molecule with anti-inflammatory, antithrombotic, anti-fat, and other effects. Periodontitis is a kind of oral inflammatory disease with high incidence, which is characterized by alveolar bone resorption leading to tooth loosening and loss. Therefore, this study aims to investigate whether theobromine intake correlates with periodontitis and whether it is a risk or protective factor for periodontitis. It hopes to provide a basis for theobromine-related diet or drugs to prevent and treat periodontitis.
Methods:
The study was based on National Health and Nutrition Examination Survey (NHANES) data from 2009–2014. The exposure factor was theobromine, derived from two-day, 24-hour total nutrient intake data from the NHANES dietary data. Periodontitis as an outcome factor was derived from the oral health component of the examination data. We used weighted multiple logistic regression, stratified analysis, and curve fitting to explore the relationship between theobromine dietary intake and periodontitis severity based on weighting and adjusting for confounding factors.
Results:
After adjusting for relevant confounding factors, weighted logistic regression showed that moderate and high levels of theobromine intake were negatively correlated with periodontitis severity (P < 0.05, OR < 1). Stratified analysis showed that race, BMI, age, diabetes, smoking, family PIR, education, and marital status had an impact on the relationship between theobromine intake and periodontitis.
Conclusion:
This study demonstrated a negative correlation between theobromine dietary intake and periodontitis, suggesting that theobromine intake may serve as a protective factor against the development of periodontitis.
Ventricular Fibrillation Occurring in the Setting of Simultaneous Type 1 Myocardial Infarction and Stress Cardiomyopathy
Authors: Youssef Salma , Deif Bishoy 
Published: June 2024

Abstract

Background: Simultaneous acute coronary syndrome and stress cardiomyopathy (SCM) are a rare occurrence. Here we describe the first case that we know of where aborted sudden death further complicates the presentation and management.
Case presentation: A 69-year-old male presents with ventricular fibrillation (VF) in the setting of acute coronary syndrome (ACS) and stress cardiomyopathy (SCM). Simultaneous ACS and SCM are unusual, and the sequence of events culminating in VF is unclear. Moreover, the concomitant presence of these entities confounds the decision to implant a defibrillator.
Conclusions: The case highlights the challenges of making a decision with respect to an ICD given the uncertainty associated with ventricular arrhythmia recurrence. Our case discusses the variables that factored into our decision making for a defibrillator implant and this can assist clinicians in building a framework to approach similar dilemmas. Here we review the literature to understand the risk of ventricular arrhythmia in stress cardiomyopathy and the utility of cardiac MRI in further risk stratifying this population.
Effect of ethylenediaminetetraacetic, etidronic, and peracetic acids with different concentrations on the removal of Enterococcus faecalis biofilms from root canal walls: an in vitro study
Authors: Zeyrek Salev , Ulusoy Özgür İlke , Akça Gülçin , Savur İlke Gaye 
Published: June 2024

Abstract

Background
To evaluate the effects of 17% ethylenediaminetetraacetic acid (EDTA), 9% and 18% etidronic acid (HEBP), and 1% and 2% peracetic acid (PAA) used alone or in combination with NaOCl on Enterococcus faecalis biofilms by using laser scanning confocal microscope.
Methods
E. faecalis biofilms were experimentally developed on the dentine discs obtained from one hundred and fifteen teeth. Infected dentine discs were randomly divided into 11 experimental (n = 10) and one control group (n = 5) according to the irrigation regimen. The percentage of dead cells in the infected samples after exposure to the different irrigation solutions was measured using a confocal laser scanning microscope. The data was statistically analyzed using the Saphiro-Wilk test and Tukey multiple comparison test with one-way ANOVA. A p-value less than 0.05 was considered to be statistically significant.
Results
The percentage of dead bacterial cells in the samples irrigated using 17% EDTA and saline was significantly lower compared to the samples irrigated with other irrigation regimens (p < 0.001). The percentage of dead bacteria observed in the samples irrigated using 9% HEBP and 18% HEBP solutions alone is lower compared to the samples irrigated using HEBP in combination with NaOCl (p < 0.001). There was no statistically significant difference between the two concentrations of peracetic acid (1–2%) and etidronic acid (9–18%) regarding biofilm elimination when these chelators were used alone or in combination with NaOCl (p > 0.001). The use of 2% peracetic acid alone in the experimentally infected samples resulted in more biofilm elimination than the use of 9% and 18% HEBP alone (p < 0.001).
Conclusion
The antimicrobial capacity of 1–2% peracetic acid is similar to its associated use with 2.5% NaOCl regarding eliminating E.faecalis biofilms from root canal walls. Therefore, irrigation of infected root canals with a single use of PAA can achieve an adequate antibacterial effect. Lower concentrations of peracetic acid and etidronic acid can be recommended to remove the E.faecalis biofilms from root canals to decrease the irrigation solutions' potential harmful effects.
Rare disease publishing trends worldwide and in China: a citespace-based bibliometric study
Authors: Kong Qi , Fan Chen-Xin , Chen Li-Ming , Zhang Ying , Yan Xin-Lei , Kang Qi , Yin Pei-Hao 
Published: June 2024

Abstract

Objective
Here, we analyzed the research status of rare diseases in China and globally over the past decade using bibliometric and scientific knowledge graph methods. We aimed to understand research trends, determine frontier topics, and explore the developments in and the differences between research conducted in China and the rest of the world.
Methods
We focused on rare disease literature indexed in the Web of Science and CNKI databases from January 2013 to December 2023. We selected studies based on inclusion and exclusion criteria. Bibliometric methods and the CiteSpace 6.1.R6 software were used to prepare knowledge graphs and perform comparative analyses of authors, institutions, content, and hot topics between Chinese and English databases.
Results
A total of 10,754 articles from the Web of Science database and 969 articles from the CNKI database met the inclusion criteria. In the past 10 years, the diagnosis and treatment of rare diseases have been a common research focus in both China and foreign countries. However, China has emphasized more on "orphan drugs," whereas foreign countries have focused more on "genes" and "management." The United States had the greatest number of publications. However, China ranks high in terms of publication volume and institutional ranking.
Conclusion
The research interest in rare diseases has gradually increased worldwide, with European and American countries maintaining a leading position. China has made significant contributions to rare disease research. However, its research focus is lagging compared to international trends, and a lack of collaboration with foreign countries exists. The diagnosis and treatment of rare diseases remain central themes in the field, whereas genetic research, artificial intelligence intervention, and sociological studies on rare disease populations are emerging as hot topics.
Wogonin Suppresses Proliferation, Invasion and Migration in Gastric Cancer cells via Targeting the JAK-STAT3 Pathway
Authors: Song Yang , zhao Hui , Yu Runze , Zhang Yang , Zou Yongxin , Liu Xiaofei , Sun Shuna 
Published: June 2024

Abstract

Wogonin is a compound extracted from the medicinal plant Scutellaria baicalensis Geogi and has been found to exert antitumor activities in a variety of malignancies. However, the molecular mechanisms involved in the anti-gastric cancer (GC) effects of wogonin remain poorly understood. In the present study, we found that wogonin treatment inhibited the proliferation of GC cells, induced apoptosis and G0/G1 cell arrest, and suppressed the migration and invasion of SGC-7901 and BGC-823 cells in vitro. In addition, wogonin inhibited in vivo tumor growth in SGC-7901 xenograft mice. Transcriptomic analysis suggested that wogonin affected several signaling pathways closely related to tumor proliferation and metastasis, including the STAT3 signaling pathway. Further research indicated that wogonin may exert antitumor effects in GC cells by downregulating the JAK-STAT3 pathway. Altogether, our results demonstrate that wogonin exerts antitumor effects by perturbing JAK-STAT3 signaling in GC cells and that wogonin may be a potential therapeutic option for GC.
Pain intensity and Disability of chronic low back pain patients receiving physiotherapy in Cameroon: A call for patients’ awareness to focus on physiotherapy treatment
Authors: Ghassi Hyacinte Trésor , Buh Franklin Chu , Muntessu Dilane Landry Nsangou , Siewe Julio Rostan , Noumoe David Léonel , Epee Paule-Laure Soppo , Douryang Maurice 
Published: June 2024

Abstract

Background
Chronic low back pain (CLBP) is one of the major causes of disability in the world especially in resource limited countries like Cameroon. To date, little or no studies in Central Africa have addressed the effects of conventional physiotherapy (CPT) treatment on CLBP as well as its combination with oral or topic traditional medicines (TM). This study aimed at evaluating the effects of CPT in pain and disability related to CLBP, and to find out if any additional effects of additional non-conventional TM with physiotherapy.
Methods
We conducted a cross sectional survey from October 2022 to April 2023 in some major physiotherapy units in Cameroon. Were included patients following physiotherapy treatment for CLBP. We used a structured questionnaire to collect general characteristics of participants; the level of pain was assessed with the VAS (Visual Analog Scale) and the impairment of physical function with the EIFEL scale (Echelle d’Incapacité Fonctionelle du Patient Lombalgique). The data collected were analyzed using SPSS. The paired Student test was used to compare the initial and final VAS and EIFEL scores. The Leverne test was used to compare treatment outcomes between patients who received CPT alone and those who received non-conventional TM. Statistical significance was calculated at P˂ 0.05.
Results
Were included in this study 158 patients with CLBP with a mean age of 46.3 [SD: 14.3]. Female were more represented (106/157, 67%). The patients underwent CPT for a mean duration of 8.9 months [SD: 15.8] at a weekly mean session frequency of 3.8, [SD:1]. Of the 158 participants, 35 (22.2%) underwent additional TM. Conventional physiotherapy significantly reduced pain (Initial VAS:7.4 [SD: 1.3]; Final VAS: 3.9 [SD: 1]; P = 0.000) and physical impairment of participants (Initial EIFEL: 15.7 [SD: 4.5]; Finale EIFEL: 6.8 [SD: 3.2]; P = 0.000). The study found no significative difference in pain (P = 0.317) and physical impairment (P = 0.302) in patients following exclusively CPT and those following physiotherapy additionally to non-conventional TM.
Conclusion
Physiotherapy treatment reduces pain and improve physical function of patients with chronic low back pain and additional non-conventional traditional treatment did not have improve further pain and disability in these patients.
Optimism as a predictor of poor comoliance with urate-lowering therapy in patients with gout: a prospective study
Authors: Zhao Wenkai , Zheng Chun , Huang Zhixiang , Huang Yukai , Huang Qidang , Chen Shuyang , Liu Yuqi , Li Tianwang 
Published: June 2024

Abstract

Background
Gout is an inflammatory disease that can cause pain and damage to joints and organs. Compliance with urate-lowering therapy (ULT) in patients with gout is poor worldwide, and few studies have focused on the association between psychology and compliance. Psychological dysfunction (such as anxiety and depression) is common in patients with gout and is correlated with health-related quality of life. This study aimed to investigate the psychological status related to poor compliance in gout patients.
Methods
A total of 530 patients with gout, 174 with ankylosing spondylitis (AS), 60 with rheumatoid arthritis (RA), and 324 healthy volunteers were included. Compliance with ULT was investigated using the medication possession ratio (MPR) over 3 months. The Life Orientation Test-Revised (LOT-R) was used to assess optimism in patients with gout and controls. The Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to evaluate the severity of anxiety and depression. First, we compared the psychological status between gout patients and controls. Therefore, Spearman rank correlation analysis was used to determine the relationships between psychological and clinical variables. Finally, binary logistic regression analyses were used to analyze the predictors of poor compliance in patients with gout.
Results
The LOT-R scores of patients with gout were higher than those of patients with AS and RA (p < 0.05), while the SAS and SDS scores of patients with gout were lower than those of patients with AS and RA (p < 0.05). Among 530 patients with gout, 55.1% had an MPR < 0.8, and the MPR was negatively correlated with the LOT-R score (p < 0.05). Insufficient education, living in the countryside, having a high SUA concentration, and having a high LOT-R score predicted poor compliance with ULT (p < 0.05).
Conclusions
Gout patients share a similar optimistic status with healthy controls but are more optimistic than AS and RA patients. However, optimistic gout patients were more likely to have poorer compliance.
Trial registration:
Not applicable.
Laser solid-phase synthesis of graphene shell-encapsulated high-entropy alloy nanoparticles
Authors: Liu Zhu , Liu Yuxiang , Yuan Jianghuai , Zhou Jiantao , Pan Kewen , Zhang Ran , Zhao Rongxia , Li Lin , Huang Yihe 
Published: June 2024

Abstract

Rapid synthesis of high-entropy alloy nanoparticles (HEA NPs) offers new opportunities to develop functional materials in widespread applications. Although some methods have successfully produced HEA NPs, these methods generally require rigorous conditions such as high pressure, high temperature, restricted atmosphere and limited substrates, which impede practical viability. In this work, we report a laser solid-phase synthesis of CrMnFeCoNi nanoparticles by laser irradiation of mixed metal precursors on a laser-induced graphene (LIG) support with a 3D porous structure. The CrMnFeCoNi nanoparticles are embraced by several graphene layers, forming graphene shell-encapsulated HEA nanoparticles. We provide an in-depth understanding of the laser solid-phase synthesis of HEA NPs on LIG supports by simulation and experimental observations, in consideration of mixed metal precursor adsorption, thermal decomposition, reduction through electrons from laser-induced thermionic emission, and liquid beads splitting. The production rate reaches up to 30 g/h under the current laser setup. The laser-synthesized graphene shell-encapsulated CrMnFeCoNi NPs loaded on LIG supports are used directly as 3D binder-free integrated electrodes and exhibited excellent electrocatalytic activity towards oxygen evolution reaction with an overpotential of 293 mV at the current density of 10 mA/cm2 and exceptional stability over 428 hours in alkaline media, outperforming the commercial RuO2 catalyst and the counterpart catalysts reported by other methods. This work also demonstrates the versatility of this technique through the successful synthesis of CrMnFeCoNi oxide, sulfide and phosphide nanoparticles.
An immersed finite element approach based on dimensional reduction for elliptic interface eigenvalue problems with radial stratified media
Authors: Wang Wei , An Jing 
Published: June 2024

Abstract

In this paper, a novel and efficient immersed finite element approach based on dimensionalreduction is proposed and studied for elliptic interface eigenvalue problems with radialstratified media. Firstly, the original problem is decomposed into a series of decoupled one-dimensional second-order interface eigenvalue problems by introducing appropriate coordinate transformations. Subsequently, a class of weighted Sobolev spaces and their approximation spaces are defined in accordance with the boundary conditions and interface jump conditions, based on which, the variational form and its discrete scheme are established for each one-dimensional second-order interface eigenvalue problem, and the error estimates for the approximation eigenvalues and eigenfunctions are theoretically proved. Finally, some numerical experiments are presented to demonstrate the stability and convergence of the algorithm.