bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human rights health care measures reporting physical fitness test for ages 6 to 17 with 10-year follow-up
Authors: Fujimori Satomi , Ashida Kazuki , Watanabe Noriaki , Nishino Tomoyuki , Sasamori Fumihito , Okuhara Masao , Tabuchi Hisaaki , Terasawa Koji 
Published: July 2024

Purpose
This study aims to compare the physical fitness test results of Japanese children in 2008 and 2018 to narrow the gap between life expectancy and healthy life expectancy and extend healthy life expectancy. In addition, this paper sought to explore the potential of implementing health education programs as a new social context to promote race equality and human rights in health and social care.

Design/methodology/approach
This study was conducted in 2008 and 2018 in Nagano Prefecture, Japan. Physical fitness tests related to growth and development were administered to participants aged 6–17 years.

Findings
Physical fitness measurements in 2018, specifically those for walking ability and endurance, were significantly inferior to those in 2008. In a gender-specific analysis, boys outperformed girls in muscle strength, muscle endurance, walking ability and endurance tests, while girls outperformed boys in the balance test.

Research limitations/implications
Most of the junior and senior high school students who participated in the EO test exceeded the upper limit of 120 s, suggesting that the load of the measurement method is low and improvement is necessary. In 2018, a large variation in 6M results was observed among participants, possibly due to the differences in the level of seriousness during the 6M test. Therefore, to ensure that junior and senior high school students properly perform the EO and 6M tests, it is necessary to devise an effective method of implementation, such as changing the physical fitness test load.

Originality/value
Mere health education is ineffective to address health inequalities. Addressing structural factors is essential to avoid unintended consequences such as increasing the gap between groups of people. However, one way to extend healthy life expectancy is to improve overall health, including differences in the health status of groups due to differences in region and socioeconomic status.
The impact of sustainable design and construction upon FM: four case studies
Authors: Lavy Sarel , Deshpande Rahul , Jadhav Tushar 
Published: July 2024

Purpose
This paper aims to analyze the impact of sustainability measures taken during the design and construction phases, by examining two categories of sustainability: energy efficiency and reducing carbon emissions and material selection and waste management. These aspects are examined from the perspectives of long-term building performance and maintenance practices, as well as user/tenant satisfaction.

Design/methodology/approach
This study includes a literature review related to the two topics under consideration, followed by a comparative case study analysis of four projects to determine practical validity. All case studies in this paper used a semi-structured survey with various project stakeholders, which helped the authors identify measures taken as well as obstacles and challenges during the process.

Findings
According to the four case studies, adequate attention should be paid to the two areas of interest during a project’s design and construction phases. Including case studies from around the world (four case studies from three different countries) offers insights into effective sustainability practices in building design and construction, providing instances of successful implementation and emphasizing the obstacles and potential when incorporating sustainability into the design and construction phases.

Research limitations/implications
The findings also show that design and construction participants and companies should reduce waste generation and carbon emissions. In addition, they should make decisions on material selection to enhance projects’ sustainability and to contribute to creating a habitable planet for the future.

Originality/value
The influence of the design and construction phases on long-term project sustainability is of major importance and concern to users, owners, designers, contractors and facility managers. This study illustrates the necessity of including sustainability measures in the design and construction phases, highlighting the importance of sustainability in building design and construction through effective implementation techniques and interdisciplinary teamwork to realize sustainable goals.
Health service requirements of mHealth app users: evidence from Hangzhou, China
Authors: Xu Zhongyang , Meng Zhiqian 
Published: July 2024

PurposeChina’s healthcare system is being burdened by the increasing prevalence of chronic diseases. Therefore, this study investigated the health service requirements of mobile health applications (mHealth apps) users in Hangzhou, China. This study aimed to propose suggestions and theoretical references to improve mHealth apps and promote their development, thereby meeting public medical and health needs and creating an efficient medical service system.Design/methodology/approachWe constructed a model of health service demands using a literature review, network survey, and semi-structured interviews. We analyzed the demand attributes using the Kano model and Better-Worse index and obtained the priority ranking of demands.FindingsThe results revealed 25 demand elements in four dimensions: must-be (M), one-dimensional (O), attractive (A), and indifferent (I) requirements. The findings suggest that mHealth app developers can optimize health services by categorizing and managing health services, focusing on middle-aged users, enhancing the professionalism of health service providers, and improving the feedback mechanism.Originality/valueStudies on mHealth apps user demands, particularly on health service needs, remain scarce. This study employed a mixed-methods approach, integrating both qualitative and quantitative research techniques, to establish a priority ranking of user health service needs for mHealth apps. The study offers recommendations and theoretical references to optimize and improve mHealth app services.HighlightsConstruct a better health service requirements model for mHealth app users.Obtain the prioritization of demand elements in the model.Propose some management suggestions to improve mHealth apps.
Precision in decision-making: a novel Z-number DEA approach for European country rankings
Authors: Eligüzel Nazmiye , Aydoğan Sena 
Published: July 2024

PurposeConventional approaches such as Data Envelopment Analysis (DEA) and Fuzzy Data Envelopment Analysis (FDEA) cannot effectively account for uncertainty, which can lead to imprecise decision-making. Furthermore, these methods frequently rely on precise numbers, ignoring the inherent uncertainty of real-world data. To address this gap, the research question arises: How can we develop a methodology that combines Z-number theory and FDEA to provide a comprehensive assessment of residency preferences in European countries while accounting for uncertainty in information reliability? The proposed methodology aims to fill this gap by incorporating Z-number theory and FDEA.Design/methodology/approachThe proposed study assesses residency preferences across 39 European countries, focusing on key factors like environment, sustainability, technology, education, and development, which significantly influence individuals' residency choices. Unlike conventional DEA and FDEA approaches, the proposed method introduces a novel consideration: dependability. This inclusion aims to refine decision-making precision by accounting for uncertainties related to data reliability. The proposed methodology utilizes an interval approach, specifically employing the a-cut approach with interval values in the second step. Unlike using crisp values, this interval programming resolves formulations to determine the efficiencies of decision-making units (DMUs).FindingsThe comprehensive findings provide valuable insights into the distinctive factors of European nations, aiding informed decision-making for residency choices. Malta (75.6%-76.1%-75.8%), Austria (78.2%-78%-76.1%), and the United Kingdom (79.3%-78.4%-77%) stand out with distinct characteristics at levels of a = 0-a = 0.5-a = 1, assuming the independence of variables of the overall evaluation. Individual consideration of each factor reveals various countries as prominent contenders, except for the environmental factor, which remains consistent across countries.Originality/valueTraditional DEA models encounter challenges when dealing with uncertainties and inaccuracies, particularly in the evaluation of large systems. To overcome these limitations, we propose integrating Z-numbers—a powerful mathematical tool for modeling uncertainty—into the conventional DEA process. Our methodology not only assesses the effectiveness of countries across various socio-economic and environmental metrics but also explicitly addresses the inherent uncertainties associated with the data. By doing so, it aims to enhance the precision of decision-making and provide valuable insights for policymakers and stakeholders.
National stereotypes in the cross-cultural service encounter: empirical evidence from Vietnam
Authors: Nguyen Quynh , Yankholmes Aaron , Ladkin Adele , Osman Hanaa 
Published: July 2024

Purpose
This study aims to investigate Vietnamese hotel workers’ use of national stereotypes in cross-cultural service encounters. The study extends the existing knowledge on service failures and recovery attempts by illustrating how national stereotypes could inform these decisions through the lens of the script theory.

Design/methodology/approach
In this qualitative study, 34 service providers were interviewed about their experience in dealing with guests from different countries in Vietnamese hotels.

Findings
Service providers categorised guests based on their countries of origin to predict their behaviour prior to guest arrivals. When the guest’s behaviour matches the expectations, the service encounters went smoothly by following existing scripts. If there is a discrepancy between the guest behaviours and expectations, it could lead to service failure and the need for new scripts. Appropriate interventions in this process could turn anecdotes into accumulated understanding of guest behaviour for better service and guest experience as a new application of national stereotypes.

Originality/value
This study advances cross-cultural service encounter research by integrating national stereotypes and script theory. It sheds new light on how national stereotypes could inform service delivery and recovery attempts in service organisations.
Is “machina” a “deus ex machina” solution to the labour shortages in tourism and hospitality?
Authors: Ivanov Stanislav 
Published: July 2024

PurposeTo evaluate the role of robots, artificial intelligence and service automation in mitigating the labour shortages in tourism and hospitality.Design/methodology/approachThis is a conceptual paper.FindingsRobots, artificial intelligence and service automation have substitution, enhancement and transformational effects on tasks and jobs. The automatability of jobs depends on the automatability of the tasks they include. Cognitive, repetitive, standardised tasks are easier to automate. Tourism jobs with more physical tasks are more difficult to automate.Originality/valueThe paper sheds light on the mechanisms through which tourism and hospitality jobs can be automated to mitigate labour shortages.
Cognate Mafic Enclaves Formed by Cumulated Mush Convection in a Granitic Magma Chamber: Evidence from Mineral Chemistry of the Triassic Zhashui Pluton, Qinling Orogen
Authors: ZHANG Hongbing , ZHOU Xuchen , LAI Shaocong , ZHANG Hua , QIN Jiangfeng 
Published: July 2024

AbstractMafic enclaves in granites are generally considered to represent coeval mafic melts that derived from metasomatized mantle, which can provide valuable information about crust–mantle interaction. Exploring the genetic links between the mafic enclaves and their host monzogranite from the Triassic Zhashui Pluton, Qinling orogenic belt. The enclaves (220 ± 4.6 Ma) and the monzogranite (220 ± 2.8 Ma) display identical zircon U‐Pb ages, and they also share similar trace element and zircon Lu‐Hf isotopes, indicating a cognate source. The monzogranite displays zircon εHf(t) values of –0.99 to +1.98, while the mafic enclaves show similar values of –0.45 to +3.26; however, differences in mineral chemistry reveal different crystallization conditions. The amphibole from the mafic enclaves has higher temperature and pressure (757°C; 2.65 kbar) compared to those of the host monzogranite (733°C; 1.96 kbar), suggesting that mafic minerals in the enclaves crystallized at an early stage. Moreover, apatite in the mafic enclaves displays slightly higher volatile contents (0.72 wt%) than those of the monzogranite (0.66 wt%), indicating a volatile‐rich condition. These results suggest that the mafic enclaves represent early hydrous mafic cumulates in the granitic chamber, and subsequent magma convection would have led to the formation of the mafic enclaves.
Homologous recombination deficiency status predicts response to immunotherapy‐based treatment in non‐small cell lung cancer patients
Authors: Gao Ai , Wang Xin , Wang Jing , Zhong Diansheng , Zhang Linlin 
Published: July 2024

AbstractBackgroundHomologous recombination deficiency (HRD) is a biomarker that predicts response to ovarian cancer treatment with poly (ADP‐ribose) polymerase (PARP) inhibitors or breast cancer treatment with first‐line platinum‐based chemotherapy. However, there are few studies on the prognosis of lung cancer patients treated with immune checkpoint inhibitor (ICI) therapy using HRD as a biomarker.MethodsWe studied the relationship between HRD status and the effectiveness of first‐line ICI‐based therapy in EGFR/ALK wild‐type metastatic non‐small cell lung cancer patients (NSCLC) patients.ResultsThis study included 22 treatment naïve NSCLC patients. The HRD score ranged from −26.37 to 92.34, with an average of 24.57. Based on analysis of the progression‐free survival (PFS) data from the included NSCLC patients, threshold traversal was carried out. HRD (+) was defined as an HRD score of 31 or higher. Kaplan–Meier PFS survival analysis showed prolonged median PFS (mPFS) in NSCLC patients with HRD (+) versus HRD (−) (N/A vs. 7.0 ms, log‐rank p = 0.029; HR 0.20, 95% CI: 0.04–0.96, likelihood‐ratio p = 0.03). In patients with PD‐L1 TPS ≥50% and HRD score ≥31 (co‐status high), the mPFS was temporarily not reached during the follow‐up period. In patients with PD‐L1 TPS <1% and HRD score <31, the mPFS was 3 ms. Cox regression analysis showed that the hazard ratio of the co‐status was 0.14 (95% CI: 0.04–0.54), which was a good prognostic factor, and the prognostic effect of co‐status was better than that of HRD score alone.ConclusionThe HRD status can be identified as an independent significance in NSCLC patients treated with first‐line ICI‐based therapy.
‘Things have changed since we last spoke…’: The impacts of parental death on the life and livelihood of a young informal vendor in Dar es Salaam, Tanzania
Authors: Salvidge Nathan 
Published: July 2024

AbstractWhile an increasing number of studies concerning youth and informality have examined the complex relationship between youth, informal work and transitions to adulthood, this literature has paid little attention to how the death of a family member presents distinctive challenges to young vendors' life and livelihood progression. Addressing this, the paper draws on a case study of a small‐scale informal worker in Dar es Salaam, Tanzania, who was participating in in‐depth ethnographic research when their father died suddenly. Through this, it investigates how parental death intersects with the challenges a young vendor experienced working informally while simultaneously attempting to achieve transitions to anticipated adulthood. Life‐mapping interviews and participatory timeline diagrams were employed, gaining rich insights into a young vendor's experiences of parental death, revealing how these were shaped by an interplay between the past, present and future. More specifically, the research, which brings together literature concerning youth, informality and family relations, explores how parental death can (re)configure a young person's household roles, responsibilities and relations in response to sudden precarity in the present, reshaping priorities and plans towards achieving goals over different timeframes. Given persistent levels of informality and uncertainty across employment in sub‐Saharan Africa and beyond, this article provides a timely contribution by highlighting the need for more studies to investigate how parental death creates and exacerbates the challenges youth vendors experience, constraining their abilities to grow and sustain their lives and livelihoods within the informal sector.
Exploring the role of viscosity–vaso‐occlusion and haemolysis–endothelial dysfunction in pain sensitization among Jamaicans with sickle cell disease
Authors: Ramsay Zachary , Ali Amza , Grant Justin , Asnani Monika 
Published: July 2024

SummaryViscosity–vaso‐occlusion (VVO) and haemolysis–endothelial dysfunction (HED) are pathophysiological mechanisms and clinical subphenotypes of sickle cell disease (SCD). Recurrent vaso‐occlusive crises (VOC) may lead to neuroplastic changes and pain sensitization. Among 257 SCD participants, we assessed the relationship of subphenotypes with pain sensitivity using quantitative sensory testing to identify heat pain thresholds (HPT) and pressure pain thresholds (PPT). VOC history and sleep, social and emotional functioning were assessed using the Adult Sickle Cell Quality of Life Measurement Information System. The ‘elbow method’ determined the optimal number of clusters as three. Clustering was performed using K‐prototypes. Among clusters 2 and 3, VOC frequency and severity were higher. Clusters 1 and 3 had lower haemoglobin, higher reticulocytes and lactate dehydrogenase and more leg ulcers. In multivariate regression, cluster 3 was associated with approximately 13.6% lower PPT compared to cluster 1, and female sex was associated with decreases in PPT and HPT at the hands and feet (p < 0.001). Hydroxyurea use and unit increases in sleep functioning and age were associated with approximately 20.1% higher foot‐PPT, 6.8% higher hand‐PPT and 2.5% higher hand‐HPT and foot‐HPT respectively. Findings suggest that a third subphenotype with mixed VVO and HED features and worse pain sensitization may exist.
MGMT protein expression is a reliable predictive biomarker for temozolomide‐containing chemotherapy in osteosarcoma
Authors: Uchihara Yoshinori , Umeda Katsutsugu , Yamada Yosuke , Ito Hiroaki , Tasaka Keiji , Isobe Kiyotaka , Akazawa Ryo , Kawabata Naoko , Saida Satoshi , Kato Itaru , Hiramatsu Hidefumi , Noguchi Takashi , Sakamoto Akio , Arakawa Yoshiki , Arakawa Ayumu , Yamamoto Nobuyuki , Hosoya Yosuke , Uemura Suguru , Watanabe Ken‐ichiro , Sano Hideki , Taga Takashi , Takita Junko 
Published: July 2024

AbstractThe prognosis of patients with osteosarcoma who experience recurrence or progression (R/P) is extremely poor, and more effective and less toxic therapies are needed. In the current study, the clinical data of osteosarcoma patients who experienced R/P were retrospectively analyzed to verify the reliability of O‐6‐methylguanine‐DNA methyltransferase (MGMT) protein expression or MGMT promoter methylation for predicting the response to off‐label temozolomide (TMZ)‐containing chemotherapy. Of the 30 evaluable patients, 9 (30%) showed no/low MGMT protein expression, whereas all 16 evaluable patients had unmethylated MGMT promoter irrespective of MGMT protein expression levels. Twenty‐three patients received TMZ‐containing chemotherapy for measurable lesions (n = 14) or as adjuvant therapy following resection of recurrent lesions (n = 9). Among 14 patients with radiologically measurable lesions, the objective response rate was higher in the MGMT no/low‐expression group (50.0%) than in the MGMT intermediate/high‐expression group with borderline significance (0%, p = 0.066). The 6‐month progression‐free survival (PFS) rate in patients with radiologically measurable lesions was significantly higher in the MGMT no/low‐expression group (50.0%) than in the MGMT intermediate/high‐expression group (0%, p = 0.036). In the multivariate analysis of the 23 patients receiving TMZ‐containing chemotherapy, MGMT expression and disease status before TMZ‐containing chemotherapy were significantly associated with PFS. No severe adverse effects were observed during TMZ‐containing chemotherapy. MGMT protein expression, but not MGMT promoter methylation, could predict a favorable outcome in patients receiving TMZ‐containing chemotherapy.
Multiplex plasma protein assays as a diagnostic tool for lung cancer
Authors: Ahamed Mohammad Tanvir , Forshed Jenny , Levitsky Adrian , Lehtiö Janne , Bajalan Amanj , Pernemalm Maria , Eriksson Lars E. , Andersson Björn 
Published: July 2024

AbstractLack of the established noninvasive diagnostic biomarkers causes delay in diagnosis of lung cancer (LC). The aim of this study was to explore the association between inflammatory and cancer‐associated plasma proteins and LC and thereby discover potential biomarkers. Patients referred for suspected LC and later diagnosed with primary LC, other cancers, or no cancer (NC) were included in this study. Demographic information and plasma samples were collected, and diagnostic information was later retrieved from medical records. Relative quantification of 92 plasma proteins was carried out using the Olink Immuno‐Onc‐I panel. Association between expression levels of panel of proteins with different diagnoses was assessed using generalized linear model (GLM) with the binomial family and a logit‐link function, considering confounder effects of age, gender, smoking, and pulmonary diseases. The analysis showed that the combination of five plasma proteins (CD83, GZMA, GZMB, CD8A, and MMP12) has higher diagnostic performance for primary LC in both early and advanced stages compared with NC. This panel demonstrated lower diagnostic performance for other cancer types. Moreover, inclusion of four proteins (GAL9, PDCD1, CD4, and HO1) to the aforementioned panel significantly increased the diagnostic performance for primary LC in advanced stage as well as for other cancers. Consequently, the collective expression profiles of select plasma proteins, especially when analyzed in conjunction, might have the potential to distinguish individuals with LC from NC. This suggests their utility as predictive biomarkers for identification of LC patients. The synergistic application of these proteins as biomarkers could pave the way for the development of diagnostic tools for early‐stage LC detection.
A safety signal for congenital strabismus associated with valproic acid: A pharmacovigilance analysis utilizing the FDA Adverse Event Reporting System database
Authors: Uwai Yuichi , Nabekura Tomohiro 
Published: July 2024

AbstractThis pharmacovigilance study investigated the relationship between antiepileptic drugs and congenital strabismus, utilizing the FDA Adverse Event Report System database between 2014 and 2023. Out of 28 347 889 reports of adverse events in 10 937 764 cases, we identified 1104 reports of strabismus and 67 of congenital strabismus. Valproic acid was the most frequently implicated primary suspect drug (95 and 14 cases, respectively). Ninety‐five reports involved transplacental valproic acid exposure, yielding an information component (IC) of 7.06 (IC‐2 × standard deviation: 5.50). A multivariate analysis showed that transplacental exposure to valproic acid correlated with strabismus (adjusted odds ratio: 8.47, 95% CI: 6.74–10.65). We revealed a robust safety signal linking valproic acid to congenital strabismus.