bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhizines occasionally occur in the genus Hypogymnia (Parmeliaceae, Ascomycota)
Authors: WEI Xin-Li , CHEN Kai , LUMBSCH H. Thorsten , WEI Jiang-Chun 
Published: January 2015

AbstractThe genus Hypogymnia is morphologically characterized by swollen lobes, a hollow medulla, perforations in the lower surface, and the absence of rhizines. In our studies on Hypogymnia spp. we found rhizines and hapters were occasionally present on the lower surface of 35 species. Morphology and anatomy of the appendage-organs were studied using dissecting, compound, and scanning electron microscopy and compared with rhizines found in the related genus Arctoparmelia. Two types of rhizine-like structures were found in Hypogymnia: slender and elongated rhizines, and thick and short hapters, both of which were few in number and sparsely distributed on the lower surface. There are no obvious differences in the morphology of rhizines between Arctoparmelia and Hypogymnia, except that rhizines are abundant in Arctoparmelia. Within Parmeliaceae, Hypogymnia belongs to the hypogymnioid clade together with the genera Arctoparmelia, Brodoa, and Pseudevernia, most of which are considered to lack rhizines. The occurrence of rhizines in Hypogymnia is consistent with the placement of Arctoparmelia in the hypogymnioid clade based on molecular data.
Molecular data support Pseudoparmelia as a distinct lineage related to Relicina and Relicinopsis (Ascomycota, Lecanorales)
Authors: BUARUANG Kawinnat , SCHARNAGL Klara , DIVAKAR Pradeep , LEAVITT Steven D. , CRESPO Ana , NASH Thomas H. , MANOCH Leka , LÜCKING Robert , LUMBSCH H. Thorsten 
Published: January 2015

AbstractThe phylogenetic position of the genus Pseudoparmelia was addressed using molecular data from five loci (mtSSU, nuLSU, ITS, Mcm7, RPB1), generated from three species and aligned with sequences from 293 samples representing all major clades of Parmeliaceae. Pseudoparmelia species form a well-supported monophyletic group that is the sister group of a clade consisting of the genera Relicina and Relicinopsis. These three genera share a thallus with a pored epicortex, isolichenan as cell wall polysaccharide, and relatively small ascospores. Morphological and chemical characters that distinguish Pseudoparmelia from the closely related Relicina and Relicinopsis are discussed. To further elucidate the relationships of these three genera, we assembled a second dataset including 15 additional samples of Relicina and Relicinopsis using three loci (mtSSU, nuLSU, ITS). All three genera are monophyletic but monophyly of Relicina lacks support and, in the mtSSU single locus tree, the genus is paraphyletic with Relicinopsis nested within. Additional studies including more Relicina species are necessary to test delimitation of the genera Relicina and Relicinopsis.
Exploring Gender Differences in the Relationships between Eldercare and Labour Force Participation
Authors: Lee Yeonjung , Tang Fengyan , Kim Kevin H. , Albert Steven M. 
Published: January 2015

RÉSUMÉCette étude a examiné la relation réciproque entre les soins des parents et la participation au marché du travail, afin de déterminer si (1) la prestation de soins est liés à l’emploi subséquent; (2) un emploi est lié à la prestation de soins subséquente; (3) la participation de la prestation de soins et la population travaillant a montré une relation réciproque à travers le temps; et (4) s’il existe des différences entre les sexes dans ces relations. Pour l’analyse, nous avons utilisé la modélisation par équation structurelle. L’échantillon de l’étude comprenait les enfants adultes de 51 ans et plus, vivant avec des parents ou beaux-parents. Aucune relation de réciprocité a été trouvée entre la prestation de soins et la participation de la population active, mais des différences de sexe étaient évidentes. Femmes soignantes en 2006 étaient moins susceptibles de travailler en 2008, bien que le statut d’emploi n’ était pas liée à la prestation de soins subséquente. En revanche, les hommes qui travaillaient en 2008 étaient moins susceptibles d’être engagés dans la prestation de soins en 2010, bien que la prestation de soins n’était pas liée à l’état de l’emploi subséquent. Ces résultats suggèrent que le sexe joue un rôle important dans la relation entre la prestation de soins et la participation au marché du travail.
Atmospheric forcing of coastal polynyas in the south-western Weddell Sea
Authors: Haid Verena , Timmermann Ralph , Ebner Lars , Heinemann Günther 
Published: January 2015

AbstractThe development of coastal polynyas, areas of enhanced heat flux and sea ice production strongly depend on atmospheric conditions. In Antarctica, measurements are scarce and models are essential for the investigation of polynyas. A robust quantification of polynya exchange processes in simulations relies on a realistic representation of atmospheric conditions in the forcing dataset. The sensitivity of simulated coastal polynyas in the south-western Weddell Sea to the atmospheric forcing is investigated with the Finite-Element Sea ice-Ocean Model (FESOM) using daily NCEP/NCAR reanalysis data (NCEP), 6 hourly Global Model Europe (GME) data and two different hourly datasets from the high-resolution Consortium for Small-Scale Modelling (COSMO) model. Results are compared for April to August in 2007–09. The two coarse-scale datasets often produce the extremes of the data range, while the finer-scale forcings yield results closer to the median. The GME experiment features the strongest winds and, therefore, the greatest polynya activity, especially over the eastern continental shelf. This results in higher volume and export of High Salinity Shelf Water than in the NCEP and COSMO runs. The largest discrepancies between simulations occur for 2008, probably due to differing representations of the ENSO pattern at high southern latitudes. The results suggest that the large-scale wind field is of primary importance for polynya development.
A cluster-randomized trial determining the efficacy of caterpillar cereal as a locally available and sustainable complementary food to prevent stunting and anaemia
Authors: Bauserman Melissa , Lokangaka Adrien , Gado Justin , Close Kelly , Wallace Dennis , Kodondi Kule-Koto , Tshefu Antoinette , Bose Carl 
Published: January 2015

AbstractObjectiveWe conducted a cluster-randomized controlled trial to assess the efficacy of a cereal made from caterpillars, a micronutrient-rich, locally available alternative animal-source food, on reducing stunting and anaemia in infants in the Democratic Republic of Congo.DesignSix-month-old infants were cluster randomized to receive either caterpillar cereal daily until 18 months of age or the usual diet. At 18 months of age, anthropometric measurements and biological samples were collected.SettingThe rural Equateur Province in the Democratic Republic of Congo.SubjectsOne hundred and seventy-five infants followed from 6 to 18 months of age.ResultsStunting was common at 6 months (35 %) and the prevalence increased until 18 months (69 %). There was no difference in stunting prevalence at 18 months between the intervention and control groups (67 % v. 71 %, P=0·69). Infants in the cereal group had higher Hb concentration than infants in the control group (10·7 v. 10·1 g/dl, P=0·03) and fewer were anaemic (26 v. 50 %, P=0·006), although there was no difference in estimates of body Fe stores (6·7 v. 7·2 mg/kg body weight, P=0·44).ConclusionsSupplementation of complementary foods with caterpillar cereal did not reduce the prevalence of stunting at 18 months of age. However, infants who consumed caterpillar cereal had higher Hb concentration and fewer were anaemic, suggesting that caterpillar cereal might have some beneficial effect. The high prevalence of stunting at 6 months and the lack of response to this micronutrient-rich supplement suggest that factors other than dietary deficiencies also contribute to stunting.
Angelman syndrome-associated ubiquitin ligase UBE3A/E6AP mutants interfere with the proteolytic activity of the proteasome
Authors: Tomaić V , Banks L 
Published: January 2015

AbstractAngelman syndrome, a severe neurodevelopmental disease, occurs primarily due to genetic defects, which cause lack of expression or mutations in the wild-type E6AP/UBE3A protein. A proportion of the Angelman syndrome patients bear UBE3A point mutations, which do not interfere with the expression of the full-length protein, however, these individuals still develop physiological conditions of the disease. Interestingly, most of these mutations are catalytically defective, thereby indicating the importance of UBE3A enzymatic activity role in the Angelman syndrome pathology. In this study, we show that Angelman syndrome-associated mutants interact strongly with the proteasome via the S5a proteasomal subunit, resulting in an overall inhibitory effect on the proteolytic activity of the proteasome. Our results suggest that mutated catalytically inactive forms of UBE3A may cause defects in overall proteasome function, which could have an important role in the Angelman syndrome pathology.
MicroRNA-141 inhibits tumor growth and metastasis in gastric cancer by directly targeting transcriptional co-activator with PDZ-binding motif, TAZ
Authors: Zuo Q-F , Zhang R , Li B-S , Zhao Y-L , Zhuang Y , Yu T , Gong L , Li S , Xiao B , Zou Q-M 
Published: January 2015

AbstractGastric cancer (GC) is a biologically heterogeneous disease accompanying various genetic and epigenetic alterations, and the molecular mechanisms underlying this disease are complex and not completely understood. Increasing evidence shows that abnormal microRNA (miRNA) expression is involved in GC tumorigenesis, but the role of specific miRNAs involved in this disease remains elusive. MiR-141 was previously reported to act as tumor suppressors or oncogenes in diverse cancers. However, their accurate expression, function and mechanism in GC are largely unclear. Here we found that the expression of miR-141 was significantly reduced in GC compared with paired adjacent normal tissues and was significantly correlated with a more aggressive phenotype of GC in patients. Ectopic expression of miR-141 mimics in GC cell lines resulted in reduced proliferation, invasion and migration, and inhibition of miR-141 in GC cell lines promoted cell proliferation, invasion and migration in vitro. We further demonstrated that miR-141 acted as tumor suppressors through targeting transcriptional co-activator with PDZ-binding motif (TAZ) in GC. Moreover, the inverse relationship between miR-141 and its target was verified in patients and xenograft mice. Finally, overexpression of miR-141 suppressed tumor growth and pulmonary metastasis in nude mice. Take together, we identified that miR-141 is a potent tumor suppressor in the stomach, and its growth inhibitory effects are, in part, mediated through its downstream target gene, TAZ. These findings implied that miR-141 might be employed as novel prognostic markers and therapeutic targets of GC.
CtBP maintains cancer cell growth and metabolic homeostasis via regulating SIRT4
Authors: Wang L , Zhou H , Wang Y , Cui G , Di L-j 
Published: January 2015

AbstractCancer cells rely on glycolysis to maintain high levels of anabolism. However, the metabolism of glucose via glycolysis in cancer cells is frequently incomplete and results in the accumulation of acidic metabolites such as pyruvate and lactate. Thus, the cells have to develop strategies to alleviate the intracellular acidification and maintain the pH stability. We report here that glutamine consumption by cancer cells has an important role in releasing the acidification pressure associated with cancer cell growth. We found that the ammonia produced during glutaminolysis, a dominant glutamine metabolism pathway, is critical to resist the cytoplasmic acidification brought by the incomplete glycolysis. In addition, C-terminal-binding protein (CtBP) was found to have an essential role in promoting glutaminolysis by directly repressing the expression of SIRT4, a repressor of glutaminolysis by enzymatically modifying glutamate dehydrogenase in mitochondria, in cancer cells. The loss of CtBP in cancer cells resulted in the increased apoptosis due to intracellular acidification and the ablation of cancer cell metabolic homeostasis represented by decreased glutamine consumption, oxidative phosphorylation and ATP synthesis. Importantly, the immunohistochemistry staining showed that there was excessive expression of CtBP in tumor samples from breast cancer patients compared with surrounding non-tumor tissues, whereas SIRT4 expression in tumor tissues was abolished compared with the non-tumor tissues, suggesting CtBP-repressed SIRT4 expression contributes to the tumor growth. Therefore, our data suggest that the synergistically metabolism of glucose and glutamine in cancer cells contributes to both pH homeostasis and cell growth. At last, application of CtBP inhibitor induced the acidification and apoptosis of breast cancer cells and inhibited glutaminolysis in engrafted tumors, suggesting that CtBP can be potential therapeutic target of cancer treatment.
ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells
Authors: Zhang Yuzhou , Jiao Yue , Liu Zhaohui , Zhu Yu-Xian 
Published: January 2015

AbstractThe quiescent centre (QC) in the Arabidopsis root apical meristem is essential for stem cell organization. Here we show that the loss of REPRESSOR OF WUSCHEL1 (ROW1), a PHD domain-containing protein, leads to QC failure, defects in cell differentiation and ectopic expression of WUSCHEL-RELATED HOMEOBOX 5 (WOX5) in cells that normally express ROW1. The wox5-1/row1-3 double mutants show similar phenotypes to wox5-1 indicating that WOX5 is epistatic to ROW1. ROW1 specifically binds trimethylated histone H3 lysine 4 (H3K4me3) in the WOX5 promoter region to repress its transcription. QC expression of ROW1 results in a wox5-1-like phenotype with undetectable WOX5 transcripts. We propose that ROW1 is essential for QC maintenance and for stem cell niche development through the repression of WOX5 in the proximal meristem.
Responses of plant nutrient resorption to phosphorus addition in freshwater marsh of Northeast China
Authors: Mao Rong , Zeng De-Hui , Zhang Xin-Hou , Song Chang-Chun 
Published: January 2015

AbstractAnthropogenic activities have increased phosphorus (P) inputs to most aquatic and terrestrial ecosystems. However, the relationship between plant nutrient resorption and P availability is still unclear and much less is known about the underlying mechanisms. Here, we used a multi-level P addition experiment (0, 1.2, 4.8 and 9.6 g P m−2 year−1) to assess the effect of P enrichment on nutrient resorption at plant organ, species and community levels in a freshwater marsh of Northeast China. The response of nutrient resorption to P addition generally did not vary with addition rates. Moreover, nutrient resorption exhibited similar responses to P addition across the three hierarchical levels. Specifically, P addition decreased nitrogen (N) resorption proficiency, P resorption efficiency and proficiency, but did not impact N resorption efficiency. In addition, P resorption efficiency and proficiency were linearly related to the ratio of inorganic P to organic P and organic P fraction in mature plant organs, respectively. Our findings suggest that the allocation pattern of plant P between inorganic and organic P fractions is an underlying mechanism controlling P resorption processes and that P enrichment could strongly influence plant-mediated biogeochemical cycles through altered nutrient resorption in the freshwater wetlands of Northeast China.
Serotonin Deficiency Exacerbates Acetaminophen-Induced Liver Toxicity In Mice
Authors: Zhang Jingyao , Song Sidong , Pang Qing , Zhang Ruiyao , Zhou Lei , Liu Sushun , Meng Fandi , Wu Qifei , Liu Chang 
Published: January 2015

AbstractAcetaminophen (APAP) overdose is a major cause of acute liver failure. Peripheral 5-hydroxytryptamine (serotonin, 5-HT) is a cytoprotective neurotransmitter which is also involved in the hepatic physiological and pathological process. This study seeks to investigate the mechanisms involved in APAP-induced hepatotoxicity, as well as the role of 5-HT in the liver's response to APAP toxicity. We induced APAP hepatotoxicity in mice either sufficient of serotonin (wild-type mice and TPH1-/- plus 5- Hydroxytryptophan (5-HTP)) or lacking peripheral serotonin (Tph1-/- and wild-type mice plus p-chlorophenylalanine (PCPA)).Mice with sufficient 5-HT exposed to acetaminophen have a significantly lower mortality rate and a better outcome compared with mice deficient of 5-HT. This difference is at least partially attributable to a decreased level of inflammation, oxidative stress and endoplasmic reticulum (ER) stress, Glutathione (GSH) depletion, peroxynitrite formation, hepatocyte apoptosis, elevated hepatocyte proliferation, activation of 5-HT2B receptor, less activated c-Jun NH2-terminal kinase (JNK) and hypoxia-inducible factor (HIF)-1α in the mice sufficient of 5-HT versus mice deficient of 5-HT. We thus propose a physiological function of serotonin that serotonin could ameliorate APAP-induced liver injury mainly through inhibiting hepatocyte apoptosis ER stress and promoting liver regeneration.
More about the doubling degeneracy operators associated with Majorana fermions and Yang-Baxter equation
Authors: Yu Li-Wei , Ge Mo-Lin 
Published: January 2015

AbstractA new realization of doubling degeneracy based on emergent Majorana operator Γ presented by Lee-Wilczek has been made. The Hamiltonian can be obtained through the new type of solution of Yang-Baxter equation, i.e. "Equation missing" -matrix. For 2-body interaction, "Equation missing" gives the “superconducting” chain that is the same as 1D Kitaev chain model. The 3-body Hamiltonian commuting with Γ is derived by 3-body "Equation missing" -matrix, we thus show that the essence of the doubling degeneracy is due to "Equation missing". We also show that the extended Γ′-operator is an invariant of braid group BN for odd N. Moreover, with the extended Γ′-operator, we construct the high dimensional matrix representation of solution to Yang-Baxter equation and find its application in constructing 2N-qubit Greenberger-Horne-Zeilinger state for odd N.
Subperiosteal Transmission Of Intra-Articular Pressure Between Articulated And Stationary Joints
Authors: Pitkin Mark , Muppavarapu Raghuveer , Cassidy Charles , Pitkin Emil 
Published: January 2015

AbstractHydrostatic pressures can be transmitted between synovial capsules. In each of ten rabbits, we simultaneously measured pressure in two joints, one of which was passively ranged and the other of which was kept stationary. The intra-articular pressure inside the stationary joint changed every time its companion joint was ranged. But the pressure in the stationary joint did not change when the periosteum was transected above the ranged joint. This phenomenon was observed in all four animals that served as their own controls. The study suggests that the intra-articular pressure was transmitted through the space between the periosteum and the bone surface. Alternative explanations, like measurements of venous blood pressure, did not show correlation with hydrostatic pressure changes in the joints. The Floating Skeleton concept suggests a biomechanical rationale for this newly observed phenomenon: that there exists a subperiosteal hydrostatic connection of synovial joints and that this “net” distributes excess pressures among joints through the periosteal sheath to sustain the integrity of the joint contacting surfaces over a lifetime.
The secreted factor Ag1 missing in higher vertebrates regulates fins regeneration in Danio rerio
Authors: Ivanova Anastasiya S. , Shandarin Igor N. , Ermakova Galina V. , Minin Andrey A. , Tereshina Maria B. , Zaraisky Andrey G. 
Published: January 2015

AbstractAgr family includes three groups of genes, Ag1, Agr2 and Agr3, which encode the thioredoxin domain-containing secreted proteins and have been shown recently to participate in regeneration of the amputated body appendages in amphibians. By contrast, higher vertebrates have only Agr2 and Agr3, but lack Ag1 and have low ability to regenerate the body appendages. Thus, one may hypothesize that loss of Ag1 in evolution could be an important event that led to a decline of the regenerative capacity in higher vertebrates. To test this, we have studied now the expression and role of Ag1 in the regeneration of fins of a representative of another large group of lower vertebrates, the fish Danio rerio. As a result, we have demonstrated that amputation of the Danio fins, like amputation of the body appendages in amphibians, elicits an increase of Ag1 expression in cells of the stump. Furthermore, down-regulation of DAg1 by injections of Vivo-morpholino antisense oligonucleotides resulted in a retardation of the fin regeneration. These data are in a good agreement with the assumption that the loss of Ag1 in higher vertebrates ancestors could lead to the reduction of the regenerative capacity in their modern descendants.
Efficacy of the Modifying Phonation Intervals (MPI) Stuttering Treatment Program With Adults Who Stutter
Authors: Ingham Roger J. , Ingham Janis C. , Bothe Anne K. , Wang Yuedong , Kilgo Martin 
Published: January 2015

Purpose
This study compared a new adult stuttering treatment program (Modifying Phonation Intervals, or MPI) with the standard of care for reducing stuttered speech in adults (prolonged speech).

Method
Twenty-seven adults who stutter were assigned to either MPI or prolonged speech treatment, both of which used similar infrastructures. Speech and related variables were assessed in 3 within-clinic and 3 beyond-clinic speaking situations for participants who successfully completed all treatment phases.

Results
At transfer, maintenance, and follow-up, the speech of 14 participants who successfully completed treatment was similar to that of normally fluent adults. Successful participants also showed increased self-identification as a “normal speaker,” decreased self-identification as a “stutterer,” reduced short intervals of phonation, and some increased use of longer duration phonation intervals. Eleven successful participants received the MPI treatment, and 3 received the prolonged speech treatment.

Conclusions
Outcomes for successful participants were very similar for the 2 treatments. The much larger proportion of successful participants in the MPI group, however, combined with the predictive value of specific changes in PI durations suggest that MPI treatment was relatively more effective at assisting clients to identify and change the specific speech behaviors that are associated with successful treatment of stuttered speech in adults.