bluuebunny/crossref_metadata_2025_split huggingface dataset:
Operationalizing and digitizing person-centered daily functioning: a case for functionomics
Authors: Janssen Esther R.C. , Punt Ilona M. , van Soest Johan , Heerkens Yvonne F. , Stallinga Hillegonda A. , ten Napel Huib , van Rhijn Lodewijk W. , Mons Barend , Dekker Andre , Willems Paul C. , van Meeteren Nico L.U. 
Published: June 2024

AbstractAn ever-increasing amount of data on a person’s daily functioning is being collected, which holds information to revolutionize person-centered healthcare. However, the full potential of data on daily functioning cannot yet be exploited as it is mostly stored in an unstructured and inaccessible manner. The integration of these data, and thereby expedited knowledge discovery, is possible by the introduction of functionomics as a complementary ‘omics’ initiative, embracing the advances in data science. Functionomics is the study of high-throughput data on a person’s daily functioning, that can be operationalized with the International Classification of Functioning, Disability and Health (ICF).A prerequisite for making functionomics operational are the FAIR (Findable, Accessible, Interoperable, and Reusable) principles. This paper illustrates a step by step application of the FAIR principles for making functionomics data machine readable and accessible, under strictly certified conditions, in a practical example. Establishing more FAIR functionomics data repositories, analyzed using a federated data infrastructure, enables new knowledge generation to improve health and person-centered healthcare. Together, as one allied health and healthcare research community, we need to consider to take up the here proposed methods.
Effects of non-pharmacological interventions for adults with subjective cognitive decline: a network meta-analysis and component network meta-analysis
Authors: Yu Xiao-Hong , Li Xin-Ru , Du Zhi-Run , Zhang Yu , Fei Yang , Tang Wen-Ping , Li Xian-Wen , Zhao Qing 
Published: June 2024

Abstract
Background
Non-pharmacological interventions have a myriad of available intervention options and contain multiple components. Whether specific components of non-pharmacological interventions or combinations are superior to others remains unclear. The main aim of this study is to compare the effects of different combinations of non-pharmacological interventions and their specific components on health-related outcomes in adults with subjective cognitive decline.

Methods
PubMed, Embase, Cochrane, CINAHL, PsycINFO, CENTRAL, Web of Science, and China’s two largest databases, CNKI and Wanfang, were searched from inception to 22nd, January 2023. Randomized controlled trials using non-pharmacological interventions and reporting health outcomes in adults with subjective cognitive decline were included. Two independent reviewers screened studies, extracted data, and assessed risk of bias. Component network meta-analysis was conducted employing an additive component model for network meta-analysis. This study followed the PRISMA reporting guideline and the PRISMA checklist is presented in Additional file 2.

Results
A total of 39 trials with 2959 patients were included (range of mean ages, 58.79–77.41 years). Resistance exercise might be the optimal intervention for reducing memory complaints in adults with subjective cognitive decline; the surface under the cumulative ranking p score was 0.888, followed by balance exercise (p = 0.859), aerobic exercise (p = 0.832), and cognitive interventions (p = 0.618). Music therapy, cognitive training, transcranial direct current stimulation, mindfulness therapy, and balance exercises might be the most effective intervention components for improving global cognitive function (iSMD, 0.83; 95% CI, 0.36 to 1.29), language (iSMD, 0.31; 95% CI, 0.24 to 0.38), ability to perform activities of daily living (iSMD, 0.55; 95% CI, 0.21 to 0.89), physical health (iSMD, 3.29; 95% CI, 2.57 to 4.00), and anxiety relief (iSMD, 0.71; 95% CI, 0.26 to 1.16), respectively.

Conclusions
The form of physical activity performed appears to be more beneficial than cognitive interventions in reducing subjective memory complaints for adults with subjective cognitive decline, and this difference was reflected in resistance, aerobic, and balance exercises. Randomized clinical trials with high-quality and large-scale are warranted to validate the findings.

Trial registration
PROSPERO registry number. CRD42022355363.
Alteration of the immune microenvironment in the axillary metastatic lymph nodes of luminal A breast cancer patients
Authors: Wu Min , Wang Shuo , Yuan Keyu , Xiong Bingjun , Li Yanping , Lyu Shuzhen 
Published: June 2024

Abstract
Background
The alteration of the immune microenvironment in the axillary metastatic lymph nodes of luminal A breast cancer patients is still unclear.

Methods
Postsurgical tissues from the enrolled luminal A BCs were divided into five categories: primary BC lesion at stage N0 (PL1), primary BC lesion at stage N1 (PL2), negative axillary lymph node at stage N0 BC (LN1), negative axillary lymph node at stage N1 BC (LN2), and positive axillary lymph node at stage N1 BC (LN3). The frequencies of positive immune markers (CD4, CD8, PD1, PD-L1, T-cell immunoglobulin and mucin domain 3 (TIM3), and forkhead box protein 3 (Foxp3)) in the above tissues were quantified by AKOYA Opal Polaris 7 Color Manual IHC Detection Kit.

Results
A total of 50 female patients with luminal A BC were enrolled in this study. Among these patients, 23 had stage N1 disease, and 27 had stage N0 disease. Compared with that in the PL2 subgroup, the frequency of PD-1-positive cells was significantly greater in the PL1 subgroup, whether at the stromal or intratumoral level (P value < 0.05). Both the frequency of CD8 + T cells in LN1 and that in LN2 were significantly greater than that in LN3 (P value < 0.05). The frequency of TIM3 + T cells in LN1 was significantly greater than that in PL1 (P value < 0.05). The frequency of CD8 + TIM3 + T cells was significantly greater in both the LN2 and LN3 groups than in the PL2 group (P value < 0.05). The frequency of CD4 + Foxp3 + T cells was significantly greater in LN1 than in PL1 (P value < 0.05), which was the same for both LN3 and PL2 (P value < 0.05).

Conclusion
Increased frequencies of CD8 + PD1+, CD8 + TIM3 + and CD4 + Foxp3 + T cells might inhibit the immune microenvironment of axillary metastatic lymph nodes in luminal A breast cancer patients and subsequently promote lymph node metastasis.
Heparin-induced thrombocytopenia in extracorporeal membrane oxygenation-supported patients: a systematic review and meta-analysis
Authors: Song Danyu , Jin Yu , Zhang Yang , Zhou Zhou 
Published: June 2024

Abstract
Background
In recent years, extracorporeal membrane oxygenation (ECMO) has been increasingly used in critically ill patients with respiratory or cardiac failure. Heparin is usually used as anticoagulation therapy during ECMO support. However, heparin-induced thrombocytopenia (HIT) in ECMO-supported patients, which results in considerable morbidity and mortality, has not yet been well described. This meta-analysis and systematic review aimed to thoroughly report the incidence of HIT on ECMO, as well as the characteristics and outcomes of HIT patients.

Methods
We searched the PubMed, Embase, Cochrane Library, and Scopus databases for studies investigating HIT in adult patients supported by ECMO. All studies conforming to the inclusion criteria were screened from 1975 to August 2023. Nineteen studies from a total of 1,625 abstracts were selected. The primary outcomes were the incidence of HIT and suspected HIT.

Results
The pooled incidence of HIT in ECMO-supported patients was 4.2% (95% CI: 2.7–5.6; 18 studies). A total of 15.9% (95% CI: 9.0-22.8; 12 studies) of patients on ECMO were suspected of having HIT. Enzyme-linked immunosorbent assay (ELISA) is the most commonly used immunoassay. The median optical density (OD) of the ELISA in HIT-confirmed patients ranged from 1.08 to 2.10. In most studies, the serotonin release assay (SRA) was performed as a HIT-confirming test. According to the subgroup analysis, the pooled incidence of HIT in ECMO patients was 2.7% in studies whose diagnostic mode was functional assays, which is significantly lower than the incidence in studies in which the patients were diagnosed by immunoassay (14.5%). Argatroban was most commonly used as an alternative anticoagulation agent after the withdrawal of heparin. Among confirmed HIT patients, 45.5% (95% CI: 28.8–62.6) experienced thrombotic events, while 50.1% (95% CI: 24.9–75.4) experienced bleeding events. Overall, 46.6% (95% CI: 30.4–63.1) of patients on ECMO with HIT died.

Conclusion
According to our study, the pooled incidence of HIT in ECMO-supported patients is 4.2%, and it contributes to adverse outcomes. Inappropriate diagnostic methods can easily lead to misdiagnosis of HIT. Further research and development of diagnostic algorithms and laboratory assays are warranted.
Embolization treatment of right pulmonary artery agenisis with patent ductus arteriosus causing pulmonary hypertension and hemoptysis: a case report and literature review
Authors: Wei Fan , Yaowen Chang , Wenhui Wang 
Published: June 2024

AbstractAs the pediatric patient with right pulmonary artery agenesis (PAA) matured, she progressively presented symptoms of pulmonary hypertension and hemoptysis. There is limited clinical literature on this condition, and currently, there is no consensus regarding its diagnosis and treatment. This article presents a case study of a 16-year-old female patient with right pulmonary artery hypoplasia, providing a comprehensive summary and analysis of her developmental progression, pathology, diagnosis, and treatment.
Circular RNA HSDL2 promotes breast cancer progression via miR-7978 ZNF704 axis and regulating hippo signaling pathway
Authors: Wang Dandan , Yang Sujin , Lyu Mengmeng , Xu Liping , Zhong Shanliang , Yu Dandan 
Published: June 2024

AbstractCircular RNAs (circRNAs) are a new group of endogenous RNAs recently found to be involved in the development of various diseases, including their confirmed involvement in the progression of several types of cancers. Unluckily, the abnormal expression and functions of circRNAs in breast cancer shall be further investigated. This work aims to elucidate the action and molecular mechanism of circHSDL2 in the malignant progression of breast cancer. Differential expression profiles of circRNAs in breast cancer tissues relative to normal breast tissues and in the exosomes of breast cancer patients compared to healthy women were analyzed from databases to identify potentially functional circRNAs. CircHSDL2 was selected for further investigation. Cell proliferation, migration and invasion assays were done to assess the effect of circHSDL2 overexpression on breast cancer cells. Bioinformatics test and dual-luciferase reporter experiments were done to explore the interaction between circHSDL2 and miRNA. Downstream target genes were further investigated through proteomics analysis and Western blotting. The influence of circHSDL2 on breast cancer in vivo was evaluated through xenograft experiments in nude mice. Functional analysis demonstrated circHSDL2 overexpression promoted the division, movement, and invasion of breast cancer cells both in vivo and in vitro. Mechanistically, circHSDL2 acted as a sponge for miR-7978 to affect ZNF704 expression and thereby regulate the Hippo pathway in breast cancer cells. In conclusion, circHSDL2 regulates the Hippo pathway through the miR-7978/ZNF704 axis to facilitate the malignancy of breast cancer. This may be a potential biomarker and treatment target.
A modified fuzzy Adomian decomposition method for solving time-fuzzy fractional partial differential equations with initial and boundary conditions
Authors: Saeed Nagwa A. , Pachpatte Deepak B. 
Published: June 2024

AbstractThis research article introduces a novel approach based on the fuzzy Adomian decomposition method (FADM) to solve specific time fuzzy fractional partial differential equations with initial and boundary conditions (IBCs). The proposed approach addresses the challenge of incorporating both initial and boundary conditions into the FADM framework by employing a modified approach. This approach iteratively generates a new initial solution using the decomposition method. The method presented here offers a significant contribution to solving fuzzy fractional partial differential equations (FFPDEs) with fuzzy IBCs, a topic that has received limited attention in the literature. Furthermore, it satisfies a high convergence rate with minimal computational complexity, establishing a novel aspect of this research. By providing a series solution with a small number of recursive formulas, this method enhances accuracy and emerges as a preferred choice for tackling FFPDEs with mixed initial and boundary conditions. The effectiveness of the proposed technique is further supported by the inclusion of several illustrative examples.
Transcranial alternating current stimulation (tACS) at gamma frequency: an up-and-coming tool to modify the progression of Alzheimer’s Disease
Authors: De Paolis Maria Luisa , Paoletti Ilaria , Zaccone Claudio , Capone Fioravante , D’Amelio Marcello , Krashia Paraskevi 
Published: June 2024

AbstractThe last decades have witnessed huge efforts devoted to deciphering the pathological mechanisms underlying Alzheimer’s Disease (AD) and to testing new drugs, with the recent FDA approval of two anti-amyloid monoclonal antibodies for AD treatment. Beyond these drug-based experimentations, a number of pre-clinical and clinical trials are exploring the benefits of alternative treatments, such as non-invasive stimulation techniques on AD neuropathology and symptoms. Among the different non-invasive brain stimulation approaches, transcranial alternating current stimulation (tACS) is gaining particular attention due to its ability to externally control gamma oscillations. Here, we outline the current knowledge concerning the clinical efficacy, safety, ease-of-use and cost-effectiveness of tACS on early and advanced AD, applied specifically at 40 Hz frequency, and also summarise pre-clinical results on validated models of AD and ongoing patient-centred trials.
The risk of negative feedback loops in some weighted measures of crime harm
Authors: Lewis Sam , Pina-Sánchez Jose , Birks Daniel 
Published: June 2024

AbstractAnalyses of crime based upon aggregate counts of different crime types have restricted value, because they count all crime types equally irrespective of the harm caused. In response to this problem, a series of weighted measures of crime harm have been proposed. In this short contribution, we contend that the use of some crime harm metrics to inform police deployment practices has the potential to reinforce ethnic disparities in the criminal justice system through the creation of unintended negative feedback loops. We focus our analysis on the Cambridge Crime Harm Index and the Office for National Statistics (ONS) Crime Severity Score, the preeminent crime harm indexes in England and Wales. We conclude that the ONS Crime Severity Score, which is based on mean sentencing outcomes, does give cause for concern in some contexts. There is currently no evidence that the Cambridge Crime Harm Index, based on sentencing guidelines, presents the same problems.
Null models confirm nest site fidelity by male smallmouth bass, Micropterus dolomieu
Authors: Wiegmann Daniel D. , Weinersmith Kelly L. , Baylis Jeffrey R. , Newman Steven P. , Angeloni Lisa M. 
Published: June 2024

Abstract
Background
Many animals appear to preferentially renest in proximity to a site they previously occupied. Evidence of nest fidelity is often inferred from a right skewed distribution of distances between the nests of individuals that breed in two consecutive reproduction episodes, where many individuals nest some arbitrarily close distance to their prior nest and others, in the extended right tail of the distribution, nest far from the nest they previously occupied. Because right skewed distributions of inter-nest distances can arise even when individuals choose nest locations randomly, however, such inferences are prone to error. The importance of null models—used to generate patterns of individual inter-nest distances by processes that do not involve site attachment—for inferences about site fidelity has been known for decades but is still often unappreciated or ignored.

Methods
The right skewed distributions of inter-nest distances observed in two earlier studies of male smallmouth bass (Micropterus dolomieu) suggest prima facie that males exhibit nest site fidelity between annual reproduction episodes, but patterns of inter-nest distances have yet to be compared to an adequate null model. Here, we evaluate the nest site fidelity of marked male M. dolomieu in a decade-long dataset, where we apply a randomization procedure based on the rencontre probability problem to generate null models. Eight observed distributions of individual, annual inter-nest distances are compared to a year-specific null model to determine whether random processes are sufficient to explain the observed distributions of inter-nest distances.

Results
Through contrasts between observed annual inter-nest distances and results derived from null models that imposed realistic constraints on behavior, we show that some males were undoubtedly nest-site faithful. To reinforce the utility of null models and to make these kinds of models more accessible, we also provide a supplemental tutorial. The tutorial illustrates how random site choices, subject to common ecological and behavioral constraints, and even how distance is measured, can produce patterns of inter-nest distances that falsely imply nest site fidelity, or a lack of fidelity. The R code needed to reproduce these null models is included. The inference errors evident in our examples generalize to other forms of site fidelity, such as the apparent patch fidelity of certain sea bird foragers.

Conclusions
The comparisons of observed distributions of inter-nest distances with those generated by null models imply that, as suggested in prior studies, male M. dolomieu indeed exhibit annual nest site fidelity. Procedures like those we apply are necessary first steps in analyses when distributions of distances between the nests of individuals in consecutive reproduction episodes are used to infer nest-site fidelity. Why male M. dolomieu are site faithful is a question yet to be answered.
Long noncoding RNA TMPO-AS1 upregulates BCAT1 expression to promote cell proliferation in nasopharyngeal carcinoma via microRNA let-7c-5p
Authors: Wang Huan , Zhou Fuming , Wan Jia , Yu Hong , Wang Jin 
Published: June 2024

Abstract
Background
Long non-coding RNA (lncRNA) is a group of RNA transcripts that contribute to tumor development by post-transcriptionally regulating cancer-related genes. Nasopharyngeal carcinoma (NPC) is an epithelial tumor that occurs in the nasopharynx and is common in North Africa and Southeast Asia. The study investigated the functions of lncRNA TMPO-AS1 in NPC cell proliferation and apoptosis as well as its related competing endogenous RNA (ceRNA) mechanism.

Methods
Candidate microRNA and genes that may regulated by TMPO-AS1 were predicted with the bioinformatic tool starBase. TMPO-AS1 expression in NPC tissue, cells, nuclear part, and cytoplasmic part was measured by RT-qPCR. MTT assay, EdU assay, and flow cytometry analysis were carried out to evaluate NPC cell viability, proliferation, and apoptosis, respectively. RNA immunoprecipitation assay and luciferase reporter assay were conducted to detect the binding between TMPO-AS1 and let-7c-5p or that between let-7c-5p and BCAT1.

Results
TMPO-AS1 and BCAT1 showed high expression in NPC tissue and cells, while let-7c-5p was downregulated in NPC. The silencing of TMPO-AS1 suppressed NPC cell proliferation while promoting cell apoptosis. Moreover, TMPO-AS1 interacted with let-7c-5p and negatively regulated let-7c-5p expression. BCAT1 was a target of let-7c-5p and was inversely regulated by let-7c-5p in NPC cells. The repressive impact of TMPO-AS1 knockdown on NPC cell growth was countervailed by overexpressed BCAT1.

Conclusion
TMPO-AS1 accelerates NPC cell proliferation and represses cell apoptosis by interacting with let-7c-5p to regulate BCAT1 expression.
Design and research of heat dissipation system of electric vehicle lithium-ion battery pack based on artificial intelligence optimization algorithm
Authors: Cheng Qingwei , Zhao Henan 
Published: June 2024

AbstractThis research focuses on the design of heat dissipation system for lithium-ion battery packs of electric vehicles, and adopts artificial intelligence optimization algorithm to improve the heat dissipation efficiency of the system. By integrating genetic algorithms and particle swarm optimization, the research goal is to optimize key design parameters of the cooling system to improve temperature control and extend battery life. In the process of algorithm implementation, genetic algorithm improves the diversity of population through crossover and mutation operations, thus enhancing the global search ability. Particle swarm optimization (PSO) improves local search accuracy and convergence speed by dynamically adjusting inertia weight and learning factor. The effects of different design schemes on heat dissipation performance were systematically evaluated by using computational fluid dynamics (CFD) software. The experimental results show that the efficiency of the cooling system is significantly improved after the application of the optimization algorithm, especially in the aspects of temperature distribution uniformity and maximum temperature reduction. The optimization algorithm also successfully shortens the thermal response time of the system and improves the adaptability and stability of the system under different working conditions. The computational complexity and execution time of these algorithms are also analyzed, which proves the efficiency and feasibility of these algorithms in practical applications. This study demonstrates the practicability and effectiveness of artificial intelligence optimization algorithm in the design of heat dissipation system of lithium-ion battery pack for electric vehicles, and provides valuable reference and practical guidance for the progress of heat dissipation technology of electric vehicles in the future.