bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the urgent need for an online reproductive health education program for infertile couples: A qualitative study
Authors: Hamidzadeh Azam , Keramat Afsaneh , NaseriBooriAbadi Tahereh , Chaman Reza , Mogharabian Naser , Rabiei Zeinab , Salehin Shahrbanoo 
Published: August 2024

BACKGROUND:With the escalating utilization of online health education programs and the growing prevalence of infertility, there is an urgent requirement for a comprehensive and effective online platform that caters to the unique needs of couples facing infertility. This study aims to investigate and understand the needs and potential benefits of implementing an online reproductive health education program for infertile couples.MATERIALS AND METHODS:This research was a qualitative study conducted in Shahroud City, Iran from May 2022 to June 2022. Sixteen semi-structured interviews were conducted with infertile people and key informants. Sampling method used in this study was purpose-based with maximum variety. All interviews were digitally recorded and transcribed verbatim in Persian and analyzed using conventional content analysis approach. MAXQDA software version 12 was used to facilitate data analysis.RESULTS:From the data analysis, 2 themes, 3 main categories, and 16 subcategories emerged. The themes included “Reproductive Health Education Needs” and “Preferences for Internet-based Reproductive Health Education and Support.” The first theme consisted 2 categories Reproductive health literacy and Emotional and Psychological Support. The second theme included one category: Technical and Logistical Considerations.CONCLUSION:The data analysis of this study has revealed significant insights into the needs and preferences of infertile couples regarding Internet-based reproductive health education and support. These findings provide valuable guidance for the development and implementation of Internet-based reproductive health education programs tailored to the specific needs of infertile couples.
Identification of emotion schemes in women with premenstrual dysphoric disorder (PMDD) using an emotion-focused therapy (EFT) approach: A qualitative study
Authors: Dehnavi Saeideh Izadi , Mortazavi Seyede Salehe , Ramezani Mohammad Arash , Gharraee Banafshe , Ashouri Ahmad 
Published: August 2024

BACKGROUND:
In women with premenstrual dysphoric disorder (PMDD), emotional problems constitute most of their symptoms. This study aimed to identify the emotion schemes of women with PMDD and to determine the core emotional pains at the center of the emotion scheme of PMDD to facilitate the treatment of this disorder using an emotion-focused therapy (EFT) approach.

MATERIALS AND METHODS:
This study was performed using the directed content analysis method by Hsieh and Shannon. The participants were selected by purposive sampling. The Premenstrual Symptoms Screening Tool (PSST) was used for the primary diagnosis of women, and the Structured Clinical Interview for DSM-5 (SCID-5) was conducted for the final diagnosis. A total of 10 participants were examined via in-depth interviews in this study. The emotion scheme matrix was used as a framework to identify the emotion scheme of PMDD.

RESULTS:
Based on the emotion scheme matrix, the participants’ experiences were classified into two main themes, four categories, and eight subcategories, with 37 extracted codes.

CONCLUSION:
Based on the present results, the primary and secondary emotions and behaviors in women with PMDD indicated perceptual-situational, bodily-expressive, motivational-behavioral, and symbolic-conceptual elements in line with the core emotional pains of desperation, despair, and feelings of worthlessness based on the primary maladaptive scheme of shame, which is responsible for different psychological symptoms.
Psychometric properties of the Persian version of the students’ conceptions of assessment: SCoA inventory in medical university in Iran
Authors: Akbarilakeh Maryam , Kazemy Shiva , Ahmady Soleiman , Arbabisarjou Azizollah 
Published: August 2024

BACKGROUND:
Student assessment is one of the main parts of educational planning, and improves the quality of education. Students understanding and feeling about assessment might affect significantly on learning and academic achievement. Considering the importance of this issue, and the lack of a valid and reliable Persian tool in medical universities for measuring this concept to measure students’ perceptions and understandings of assessment, the current study aim was to determine the psychometric properties of (Students’ Conceptions of Assessment – SCoA) inventory during the basic sciences students in medicine, dentistry, pharmacy in Kermanshah University of Medical Sciences.

METHODS AND MATERIALS:
This is a cross-sectional study design. In order to carry out this study, SCoA inventory was translated and culturally adopted. To measure validity, reliability, and normalize the inventory, it was distributed among the study population composed of 302 students of Kermanshah University of Medical Sciences during the academic year 1400–1401 who met the inclusion criteria. The collected data were analyzed by confirmatory factor analysis (CFA) and Cronbach’s alpha using SPSS version 23 and Amos software.

RESULTS:
The results of data analysis showed that of the 302 participants, 119 were men and 183 were women. The mean age of students was 21.69 ± 2.16 years. Content validity was calculated, and it was reported 0.88. Cronbach’s alpha was used to determine the internal consistency, and its value was 0.775. The construct validity of SCoA inventory was assessed using CFA by EQS version 6.1. The value of root mean square error of approximation (RMSEA) was 0.092 with a 98% confidence interval, and the Goodness of fit index (GFI) value was 0.99. CFA for all items loaded across four factors, and this four-factor inventory showed a good fit in the Iranian community.

CONCLUSION:
For the first time, the psychometric test of SCoA inventory has been carried out at Kermanshah University of Medical Sciences. The Persian version of this inventory has good validity and reliability in Iran and is a useful tool for measuring the SCoA in medical university. Researchers and those interested in medical education and development centers can benefit from the results of this study. Also, this inventory has been applicable to determine the attitude and perceptions of students about assessment.
Identification of Predictive Factors for Massive Transfusion Activation in Trauma Patients: A Systematic Review and Meta-analysis
Authors: Ueamsaranworakul Thosapol , Niamjumnong Ratcharin , Kornthatchapong Kumpol , Srivilaithon Winchana 
Published: August 2024

Introduction:
Acute blood loss and uncontrolled hemorrhage in trauma require quick identification and action to restore circulating volume and save the patient. These patients have the opportunity to receive massive transfusion (MT) to reduce mortality rates and avoid overtransfusion using a suitable ratio of blood components. This study aims to systematically review and analyze the predictive factors for the activation of MT protocol (MTP) in trauma patients, which is critical for improving clinical decision-making and patient outcomes.

Methods:
PubMed, ScienceDirect, Cochrane, and other sources were searched for articles from 2007 to 2020. Conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, this systematic review included original studies published in English, involving trauma patients aged 15 years or older who received MTP. The risk of bias (RoB) was assessed using the RoB in Nonrandomized Studies of Interventions-I and RoB 2 tools, and statistical analysis was performed, focusing on the homogeneity of effect sizes across trials.

Results:
The articles search identified a total of 424 studies. Nine studies met all inclusion criteria. The most common predictors were age, sex, systolic blood pressure (SBP), heart rate (HR), hemoglobin (Hb) levels, international normalized ratio (INR), base excess (BE), and lactate levels. The analysis showed that parameters such as SBP, HR, Hb, INR, BE, and lactate were significantly associated with the activation of MTP. However, age and sex were not significant predictors. The survival rate was notably lower in the MTP group compared to the non-MTP group. There was no evidence of publication bias.

Conclusion:
Several physiological parameters: low SBP, elevated HR, reduced Hb, increased INR, diminished BE, and elevated lactate are significantly correlated with an increased likelihood of necessitating MTP in trauma patients. Among those who received MTP, the survival rate was lower compared to the non-MTP group.
Quantification of Metabolic Acidosis at Bedside by S.A.L.T Approach
Authors: Seshadri Harshitha , Nileshwar Anitha , Rao Shwethapriya , Jacob Nisha Sara M. 
Published: August 2024

Introduction:
Traditionally, metabolic acidosis is analyzed using an anion gap (AG). The aim of the study was to compare the utility of quantitative David Story’s simplified Stewart approach against traditional approach to analyze metabolic acidosis. ICU setting. Analytical, cross-sectional observational study.

Methods:
Blood gas reports of 50 adult critically ill patients with primary metabolic acidosis at admission were analyzed using both approaches. With traditional approach, acidosis was classified simply as high or normal AG acidosis. With S.A.L.T approach, the components of base deficit were further quantified into sodium chloride, albumin, lactate, and other ions effects. A contribution of sodium chloride or albumin effect of > 30% to the base deficit was considered significant. The proportion of patients with such abnormalities was determined. Descriptive statistics was used.

Results:
The mean ± standard deviation (SD) age of patients was 54.52 ± 19.71 years, 52% were males, and 72% were medical admissions. The median (interquartile range [IQR]) Sequential Organ Failure Assessment score was 10 (5–13). The mean ± SD pH, bicarbonate, base excess, and albumin were 7.198 ± 0.13, 11.73 ± 4.2 mmol/L, −15.13 ± 5.6 mmol/L, and 2.9 ± 0.77 g%, respectively. The median (IQR) of serum lactate was 6.77 (1.53, 16.32) mmol/L. Hyponatremia and hypochloremia were seen in 68% and 46% of patients, respectively. Eighty-eight percent of patients had acidosis due to other ions, 52% due to lactates. Twenty-eight percent had a significant sodium chloride effect and 32% had significant hypoalbuminemia.

Conclusion:
Quantification of base deficit of metabolic acidosis using S.A.L.T approach showed changes in sodium chloride levels and hypoalbuminemia affecting base deficit in nearly 30% of the patients. Quantification of metabolic acidosis using S.A.L.T approach is likely to help treat metabolic acidosis more appropriately, with clinical implications.
Effectiveness of structured teaching program on knowledge and attitude toward foot care
Authors: TOSO Sorhodeno , NGANELA Sukhbir , AIER Temsujungla , JAMIR Tiasenla , KISO Vikehieno , ODYUO Y. Rhondeno , PHEWHUO Zhovinuo , SHIMRAY Philanim Awungshi 
Published: August 2024

Objective:
The study was aimed to assess the knowledge and attitude toward foot care and evaluate the effectiveness of structured teaching program (STP) on the knowledge and attitude of patients with diabetes mellitus regarding foot care.

Materials and Methods:
A preexperimental research design was used in this study, which was conducted in medical–surgical wards of a secondary hospital in Northeast India, Nagaland. A total of 30 subjects were recruited by consecutive sampling technique. A closed-ended structured questionnaire and 5-point Likert scale was used to assess knowledge and attitude toward foot care. A STP was administered after which posttest was done after 24 h.

Results:
The majority (86.6%) of the participants in the pretest had inadequate knowledge and 80% had negative attitudes toward foot care. After STP, 70% had moderately adequate knowledge and 53.3% had a positive attitude regarding foot care. The structured teaching program was effective in improving the knowledge and attitude at P < 0.01 which is highly significant and there was a significant association between the pretest level knowledge and duration of diabetes at P < 0.01.

Conclusion:
STP was effective in enhancing the level of knowledge and attitude toward foot care among diabetic inpatients. This type of interaction can be organized at regular intervals to reinforce knowledge and attitude toward foot care among inpatients.
Laparoscopic deroofing of a recurrent giant simple hepatic cyst in a geriatric female: Case report
Authors: Dey Sumanta , Nandy Sougata , Roy Sreetama , Ghosh Debarchan , Guhathakurta Abhishek 
Published: August 2024

Abstract
Liver cysts often have no symptoms, are benign and are usually encountered during routine abdominal imaging for other conditions. Giant cysts have a higher risk of complications. Recurrence is common, and most research papers support laparoscopic deroofing as the initial management modality even in the recurrent cases as it avoids the morbidity of laparotomy and gives better short- and long-term post-operative outcomes. Here, we present a case of a 68-year-old female who presented to the outpatient department with complaints of right-sided dull-aching abdominal pain, heaviness, early satiety and significant weight loss for the past 2 months. A laparoscopic drainage and deroofing were done, and histopathological examination of the cystic wall was consistent with benign pathology. The patient has been doing well for the past year.
Comparative Efficacy of Therapeutic Ultrasound and Nirgundi Oil Phonophoresis on Temporomandibular Joint Disorders: An Observational Study
Authors: Raja Nishanthi , Ganesan Anuradha , Krithika C. L. , Aniyan Yesoda K 
Published: August 2024

Abstract

Background:
Temporomandibular disorder (TMD) is one of the most chronic common musculoskeletal disorders causing pain and disability. Nirgundi oil, an herbal medicine with anti-inflammatory properties has proved its role in alleviating pain and various health disorders. Phonophoresis (PH) by conventional pharmacological management in persistent conditions can lead to side effects, and hence, for this reason, alternative medicine is gaining importance.

Objective:
This study aims to compare the effectiveness of therapeutic ultrasound with PH using nirgundi oil in TMD.

Subject and Methods:
Thirty patients with mild-to-severe TMD who were part of the research study were assigned at random to one of two groups. Group 1 (n = 15) received therapeutic ultrasound treatment using ultrasound gel without any therapeutic component, while Group 2 (n = 15) received therapeutic ultrasound using herbal nirgundi oil. A visual analog scale was used to measure the amount of discomfort before and after treatment. Necessary statistical analysis using Normality tests, Kolmogorov–Smirnov, and Shapiro–Wilks’s test was performed.

Results:
PH with nirgundi oil resulted in a statistically significant higher reduction in pain (P < 0.005) and increased mouth opening (P < 0.005).

Conclusion:
PH using nirgundi oil can be an effective therapy for persistent pain in TMDs.
Platelet-rich Fibrin: A Systematic Review of Its Action
Authors: Zuleika Puspa , Saleh Irsan , Murti Krisna , Liberty Iche Andriyani , Legiran  , Irfanuddin  , Surono Agus 
Published: August 2024

AbstractPurpose:We aim to conduct a literature review on actions of platelet-rich fibrin (PRF), preclinical studies in PRF utility, and its potential uses in clinical settings.Methods:We conducted a literature review based on primary studies conducted on PubMed and Europe PMC between 2012 and 2022. We included 42 articles in this review from the results of our search.Results:Epithelial tissues act as a barrier from mechanical, chemical, and temperature damage. Naturally, hemostasis acts to reduce blood loss and creates initial fibrin matrices after traumatic events or injuries. PRF is a second-generation platelet concentrate, commonly made in the form of leukocyte and PRF due to leukocyte content. Fibrin matrices in PRF allow more sustained growth factors release when compared to PRP, the first-generation platelet concentrate. PRF comes from increased proliferation and differentiation mediated by reduced proliferation of inflammatory cells and sustained release of growth factors and cytokines.Conclusions:PRF action comes from increased proliferation and differentiation from growth factors and cytokines. PRF may reduce inflammation and fibrosis to improve soft-tissue and bone healing and allow for better graft integration.
Enhancing Respiratory Functions and Cervical Proprioception with Myofascial Release and Feedback Respiratory Training in Forward Head Posture: A Pilot Randomized Controlled Trial
Authors: Panihar Usha , Joshi Shabnam 
Published: August 2024

Abstract

Context:
Forward head posture (FHP) is a prevalent abnormal posture, leading to abnormal postural angles, diminished respiratory parameters, and decline in cervical proprioception.

Aim:
The study aimed to improve head posture along with improvement in respiratory functions and cervical proprioception in FHP individuals using feedback respiratory exercises (FRE) and myofascial release (MFR) technique.

Settings and Design:
The study was a randomized controlled pilot trial, conducted at the Outpatient Department of Guru Jambheshwar University of Science and Technology, Hisar.

Materials and Methods:
Forty-eight participants of 20–45 years having FHP were randomly assigned to four groups, i.e., Group A (control group), Group B (MFR group), Group C (FRE group), and Group D (combined group). The outcome measures such as craniovertebral angle, cranial rotation angle, cranial angle, forward shoulder angle, pectoralis minor length, neck disability index, chest expansion, forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and cervical proprioception were assessed pre- and postintervention (after 6 weeks).

Statistical Analysis Used:
The comparison between the groups at baseline and postintervention was done using one-way ANOVA test and within group was performed using a paired t-test.

Results:
The results indicated significant difference in all outcome measures in all four groups during within-group comparison. Similarly, a significant difference was observed between the groups except for cervical proprioception. In addition, recruitment and retention rates were 90.56% and 100%, respectively.

Conclusions:
The study concludes MFR and FRE when given along with conventional treatment provides additional benefits in all outcome measures except cervical proprioception.
Drug-induced Acute Kidney Injury: A Clinico-etiological Study from a Tertiary Care Center in Northeast India
Authors: Sharma Manjuri , Qanoongo Faheem Nazir , Doley Prodip Kumar , Pegu Gayatri , Pegu Miranda 
Published: August 2024

Abstract

Background:
Drug-induced acute kidney injury (AKI) poses a significant challenge in clinical practice, necessitating a comprehensive understanding of its epidemiology and underlying mechanisms. This prospective study aimed to elucidate the clinico-etiological profile of drug-induced AKI in a tertiary care center in Northeast India and evaluate patient outcomes.

Methodology:
Adults diagnosed with AKI following drug exposure were enrolled in this observational study conducted from August 2022 to January 2024 at Department of Nephrology, Gauhati Medical College and Hospital. Demographic data, clinical characteristics, offending pharmaceutical agents, histopathological patterns, and outcomes were meticulously documented.

Results:
We studied 105 participants (mean age: 45 ± 10 years, 56.2% male) experiencing drug-induced AKI. Antimicrobials (24%), nonsteroidal anti-inflammatory drugs (NSAIDs) (21%), and chemotherapeutic agents (19%) were common causes, leading predominantly to acute interstitial nephritis (58%) and renal tubular epithelial cell injury (30%). Despite challenges, 73% fully recovered, with a 2% mortality rate. Age (odds ratio [OR]: 1.35, 95% confidence interval [CI]: 1.12–1.63, P = 0.002), male gender (OR: 1.84, 95% CI: 1.09–3.11, P = 0.022), diabetes (OR: 2.21, 95% CI: 1.28–3.82, P = 0.005), smoking (OR: 1.92, 95% CI: 1.06–3.48, P = 0.031), antimicrobial use (OR: 3.68, 95% CI: 2.14–6.32, P < 0.001), NSAID use (OR: 2.77, 95% CI: 1.56–4.92, P < 0.001), and chemotherapeutic use (OR: 1.57, 95% CI: 1.10–2.22, P < 0.001) were significant risk factors.

Conclusion:
This study highlights the clinico-etiological profile of drug-induced AKI in Northeast India, emphasizing antimicrobials, NSAIDs, and chemotherapeutics as major contributors. Despite the high prevalence, most patients recovered, stressing early recognition and careful medication management. Age, gender, and comorbidities play critical roles, warranting targeted interventions and vigilant pharmacovigilance to mitigate the AKI burden effectively.
A case report on hypothyroidism induced by pembrolizumab
Authors: Reji Rinku Elsa , Kurien Sara , Harikrishnan S , Jesurun R S Jacob 
Published: August 2024

Abstract:
This case report presents the clinical findings and management of a 62-year-old patient with a history of hemicolectomy and hepatic metastasis. The patient was diagnosed with microsatellite instability-high colon cancer and was treated with pembrolizumab. However, the patient developed hypothyroidism 2 months after the treatment as a side effect. This report highlights the importance of monitoring thyroid function in patients receiving pembrolizumab and discusses the management strategies for pembrolizumab-induced hypothyroidism.
Lecanemab: A novel disease-modifying drug treatment for Alzheimer’s disease
Authors: Bhanwra Sangeeta , Mahajan Sonia Shinde 
Published: August 2024

Abstract:
The advent of a new treatment strategy in the form of disease-modifying therapy for Alzheimer’s disease (AD) has been finally achieved after a prolonged wait. Lecanemab is one of such drugs that target the pathophysiology of the disease by lowering the amyloid-β plaques to change the course of this debilitating disease and to decline its further progress. It is a humanized IgG1 monoclonal antibody that was approved by the Food and Drug Administration in July 2023 for the treatment of patients with early AD and in patients with mild cognitive impairment or mild dementia.
Toxic epidermal necrolysis after levofloxacin therapy
Authors: Jenisha J. V. , Srinivasan Akila , Kumarappan Manimekalai , Shanmugam Srikanth 
Published: August 2024

Abstract:
Steven–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is an idiosyncratic, life-threatening adverse drug reaction to many medications, including anticonvulsants, antibiotics, and nonsteroidal anti-inflammatory drugs. It is of immunological origin and manifests as extensive epidermal detachment along with systemic symptoms of fever, malaise, and, in some cases, organ dysfunction. The most common antibiotics implicated in SJS/TEN are beta-lactams, sulfonamides, and fluoroquinolones. There have been a few reports of SJS/TEN with levofloxacin worldwide. We report one such case of a 32-year-old male patient who was referred to our tertiary care center with TEN after being prescribed levofloxacin for a lower respiratory tract infection by a primary health-care physician.