bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scattering of Laser Light from Mixed Micelles
Authors: Cheng Chien‐Hsin 
Published: May 2015

AbstractDynamic and static scattering of light was employed to investigate mixed micelles of two homologous anionic surfactants‐sodium octyl sulfate and sodium hexadecyl sulfate, above the phase boundary temperature and critical micelle concentrations (cmc). The results indicate that the mixed micelles change from prolate to sphcrical as the molar ratio SOS/SHS increases from 1 to 8. Below 1 or above 8, the formation of micelles is due to one surfactant dissolving the other.
Chromium Tricarbonyl η6‐Complexes of (η5‐Cyclopentadienyl)(η4‐1,3‐Diphenylcyclobutadiene)Cobalt
Authors: Hong Fung‐E , Chang Yuan‐Terng , Chen Chi‐Tain 
Published: May 2015

AbstractThe reaction of (η5‐cyclopentadienyl)(η4‐1,3‐diphenylcyclobutadiene)cobalt (I) with excess Cr(CO)3py3 in BF3OEt2 yielded two identified heterometallic compounds. Compounds II and III with one and two phenyl rings complcxed with Cr(CO)3 fragment(s), respectively. These compounds were characterized by mass, infrared, 1H and 13C NMR spectra and elemental analysis. The crystal structure of II was determined. The Cr(CO)3 fragment bends inward toward the cyclobutadicne ring due to its electron‐withdrawing ability, in accord with Hunter's postulate. A sharp line due to the non‐complexed phenyl ring was observed in the 1HNMR spectrum, which implies that five protons are magnetically equivalent. The chemical shifts of two protons of the cyclobutadiene ring decreased from I to II then to III, possibly because of diminished deshielding effect from the phenyl ring in (arene)Cr(CO)3.
Statistical Inference of Distribution of Crystal Size by X‐Ray Powder Diffraction
Authors: Chen Po‐Yi , Mou Chung‐Yuan 
Published: May 2015

AbstractWe describe a method to calculate the distribution of sizes of fine crystals from pure powder‐diffraction profile using a method of maximum entropy (MAXENT). We apply a Monte‐Carlo technique of simulated annealing to seek a global minimum of the error surface in fitting this diffraction profile. We consider pure diffraction profile (instrument de‐convoluted) of a powder specimen without lattice imperfection to a significant extent. Under these circumstances, the distribution of the pure diffraction profile can be attributed to the distribution of crystallite size. We applied this method to three cases of crystal sizes having a highly inhomogeneous distribution with certain noise‐tolerance. The results agree well with synthetic data of diffraction.
Synthesis of Five‐Membered Ring Heteroaryl Pyridines from Heteroaryllithium and N‐Ethoxycarbonylpyridinium Chlorides
Authors: Lai Long‐Li , Shin Li‐Hua , Lin Pen‐Yuan , Wang Jy‐Shih , Shiao Min‐Jen 
Published: May 2015

AbstractFurylpyridines, thienylpyridines, and imidazolylpyridines were obtained regioselectively in 40‐67% yields from the reaction of heteroaryllithiums with N‐ethoxycarbonylpyridinium chloride or N‐ethoxycarbonyl‐3‐methylpyridinium chloride in the presence of Cul in a catalytic amount at −78 °C or −50°C, then followed by oxidation. The regioselectivity of this reaction depended upon temperature of the reaction and the nature of heteroaryllithiurn.
Diastereoselective Alkylation of (Diene‐Aldehyde)Fe(CO)3 Complexes with Functionalized Zinc‐Copper Reagents NuCu(CN)Znl
Authors: Wang Jeng‐Long , Ueng Chuen‐Her , Yeh Ming‐Chang P. 
Published: May 2015

AbstractAddition of functionalized zinc‐copper reagents to the title complexes proceeds in a highly diastereoselective fashion to afford dienol complexes. The relative configurations of adducts 3d were determined by single X‐ray diffraction analysis.
Study of Crown Ether Surfactants with Pyrene Fluorescence Probe
Authors: Jane Yih‐Song , Shin Jeng‐Shong 
Published: May 2015

AbstractBoth C10H21‐18‐crown‐5 and C10H21‐15‐crown‐5 were successfully synthesized and exhibited the distinctive characteristics of surfactants. Fluorescence of pyrene was used as a sensitive probe to study the micelle formation of the crown ether surfactant. The variation of the intensity ratio (I1/I3) of the first and third vibrational fluorescence bands of pyrene was employed to determine the critical micellar concentration (CMC). Both CMC and cloud points were found to depend on the kinds of cations and the ionic strength in solution. The quenching of pyrene fluorescence is also investigated for some cations under micelle and non‐micelle circumstances.
Synthesis of Conjugated α‐D‐Hexenopyranosiduloses
Authors: Liang David Woei‐Ming , Lin Shu‐Fu , Yap Wen‐Yen , Deng Yea‐Wen 
Published: May 2015

Abstractα‐Enone sugars such as 2,3‐dideoxy‐α‐D‐hex‐2‐enopyranasid‐4‐uloses I and 3,4‐dideoxy‐α‐D‐hex‐3‐enopyranosid‐2‐uloses II involving the corresponding C‐2 and C‐4 methylated sugars 5, 10a and 10b were successfully synthesized from D‐glucose in high yields by simple laboratory processes.
Double Michael Additions of Lithium Enolate of 1,4‐Dioxaspiro[4.5]dec‐6‐en‐8‐One to Acrylates
Authors: Hung Shang‐Cheng , Liao Chun‐Chen 
Published: May 2015

AbstractDouble Michael additions of lithium enolaie of 1,4‐dioxaspiro[4.5]dec‐6‐en‐8‐one to four acrylates afforded bicyclo[2.2.2]octan‐2‐ones with high regio‐ and stereoselectivities in moderate yields.
Synthesis and Diazotization of Diethyl 6‐Amino‐2‐Hydroxyazulene‐1,3‐Dicarboxylate and Its 2‐Acetoxyl Derivative
Authors: Huang Tian‐Chyuan , Morita Tadayoshi , Lin Bing‐Bing , Lin Yun‐Shan 
Published: May 2015

AbstractDiethyl 6‐amino‐2‐hydroxyazulene‐1,3‐dicarboxylate (6a) and 2‐acetoxyl derivative (6b) were synthesized by reduction of the 6‐azido derivatives (5a,b) with zinc/acetic acid in excellent yields.5aand5bwere prepared by azidation of diethyl 2‐acetoxy‐6‐bromoazulene‐1,3‐dicarboxylate (4). Diazotization of6awith sodium nitrite in the presence of concentrated sulfuric acid in dioxane gave diethyl 2‐hydroxy‐ (7a), 2,6‐dihydroxy‐ (8a), and 2‐hydroxy‐6‐[2‐(2‐hydroxyethoxy)ethoxy]‐azulene‐1,3‐dicarboxylates (9a), in 5, 35 and 20% yields, respectively. Similar reaction of6bgave the corresponding acetates7b, 8b, and9b, compounds of the same type from6a. No evidence for the formation of 6‐diazo‐1,3‐diethoxycarbonyl‐2(6H) azulenone (2b) was obtained in the employed reaction conditions.
Asymmetric Reduction Using Lithium Aluminum Hydride Modified with Chiral Ligand Prepared from (1R)‐(‐)‐Myrtenol
Authors: Lu Ta‐Jung , Liu Shew‐Wen 
Published: May 2015

AbstractThe reduction of prochiral ketones with a chiral reducing reagent, prepared from lithium aluminum hydride and (1R,2S,3S,5R)‐(‐)‐10‐methoxypinanediol (2), produced secondary chiral alcohols in good chemical yields (57–98%) and moderate enantiomeric excess (8–72%).
Constituents of Leaves of Uncaria Hirsuta Haviland
Authors: Wu Tian‐Shung , Chan Yu‐Yi 
Published: May 2015

AbstractNine compounds, ursolic acid (1), β‐sitosteryl glucoside (2), umbelliferone (3), uncarine‐A (4), chlorogenic acid (5), rutin (6), neohesperidin (7), quercitrin (8)and afzelin (9) were isolated and characterized from fresh leaves of Uncaria hirsuta. Their structures were elucidated by spectral methods. Among them, uroslic acid (I) exhibited a cytotoxic principle of this plant.
Constituents of Flowers of Murraya Paniculata
Authors: Lin Jung‐Kuei , Wu Tian‐Shung 
Published: May 2015

AbstractThree new coumarins, yuehgesin‐A (1), ‐B (2) and ‐C (3) and 22 compounds—murracarpin (4), mupanidin (5), isomeranzin (6), murralongin (7), scopoletin (10), 7‐methoxy‐8‐(l′‐ethoxy‐2′‐hydroxy‐3′‐methyl‐3′‐butenyl)coumarin (11), umbelliferone (12), paniculatin (13), braylin (14), auraptenol (15), meranzin hydrate (16), minumicrolin (17), scopolin (18), caffeine (19), 3,3′,4′,5,5′,6,7‐heptamethoxyflavone (20), 4‐hy‐droxybenzaldebyde (21), p‐hydroxybenzoic acid (22), cis‐ and trans‐ferulic acid (23), cis‐ and transmethyl ferulate (24) and trans‐ethylferulate (25)—were isolated and characterized from fresh flowers of Murraya paniculata collected in Taiwan. Their structures were elucidated by spectral methods. The chemotaxonomy of Murraya paniculata is, discussed.
Topical Problems in Elemental Analysis of Advanced Ceramic Materials
Authors: Garten Rainer P. H. 
Published: May 2015

AbstractSelected prominent problems in the analysis of advanced ceramic materials are surveyed. The importance of reliability of results is discussed in the field of elemental trace‐ and microanalysis in view of its interaction with economy, power of detection, local resolution and speciation selectivity. Particular problems in the analysis of major constituents, trace components and microlocal distributions are based on the striking propertics of ceramics; they are exemplified. Analytical assistance must start from the beginning of the production processing, in the preparation of the powdered base materials. Determination of the stoichiometry requires high accuracy and differentiation of chemical species in bulk and surface analysis of ceramic base powders. Element trace determination by direct instrumental methods requires standard reference materials for calibration; these are currently inavailable in a sufficient variety. For optimum reliability and power of detection, element traces must be prepared in isolated form in a small excitation volume for analysis.A review on the state‐of‐the‐art of wet‐chemical combined procedures is presented. Decomposition position procedures are emphasized, due to their risk of contributing severe systematic error. Combustion in elementary fluorine is presented for decomposition of refractory materials. The performance of some direct procedures is discussed. Very efficient methods are available for element trace determinations in ceramic materials, offering high detection power. Several approaches for high‐resolution local microanalysis in non‐conductive ceramic materials are identified as the most promising development in the analysis of sintered compact ceramic products and devices.
Initial Results From the Non‐Methane Hydrocarbon Intercomparison Experiment
Authors: Apel Eric C. , Calvert Jack G. 
Published: May 2015

AbstractThe Non‐Methane Hydrocarbon Intercomparison Experiment (NOMHICE) is described. This experiment has been designed to evaluate analytical techniques currently being used by scientists throughout the world to measure ambient atmospheric hydrocarbon concentrations. NOMHICE consists of a series of planned experiments designed to identify existing problems in participating scientist's laboratories and to correct them. The various experimental steps (or phases) have been scheduled in order of increasing complexity so that problems can be addressed as they arise. Results are presented for the initial phases of this program. Phase 1 involved the circulation of a 2 component gravimetrically prepared standard to 40 laboratories throughout the world. Participants were asked to quantify but not identify the components. Phase 2 involved the circulation of a more complex 16 component gravimetrically prepared mixture to 32 participants. Participants were asked to identify and quantify the components. Further tasks are described which will be carried out in the future.
In Vivo Monitoring of Neurotransmitters with Voltammetry and Smallbore HPLC
Authors: Justice Joseph B. , Paige Newton A. , Smith Amanda D. 
Published: May 2015

AbstractThe temporal and concentration response of microdialysis probes in vivo was characterized. The temporal response was monitored using step changes in dopamine (DA) concentration which were followed with one minute sampling using smallbore HPLC. The response under three conditions was examined: in vitro sampling of DA, in vitro infusion of DA, and local infusion of DA. The dialysate DA concentration stabilized within two minutes after each change. These results suggest that relatively fast changes in DA levels in tissue can be followed by microdialysis probes. The rapid stabilization also suggests that the DA concentration profile does not extend very far from the probe.To characterize the concentration response, the linearity of the gain or loss of DA diffusing between the probe and tissue was determined. The difference in the inflow and outflow concentrations was plotted as a function of the inflow concentration. The correlation coefficient of the linear regression curve was 0.99. The zero point intercept, the extracellular concentration of DA, was 3.8 nM and the slope, or recovery, was 63.4%. There was no break at the zero point which is indicative of symmetrical diffusion into and out of the probe.
Applications of Laser‐Enhanced Ionization In Analytical Chemistry
Authors: Lin King‐Chuen 
Published: May 2015

AbstractVarious applications of laser‐enhanced ionization (LEI) in analytical chemistry are reviewed. This technique was applied to determine some physical quantities associated with a flame through development of an appropriate model. Determinations of flame temperature and atomization efficiency of an element in the flame are examples. As trace analysis is an important application of this technique, we compare the ion yield induced in a two‐step LEI with that in a one‐step LEI. The factors governing the ion enhancement via two‐step excitation are examined in order to make efficient use of the two‐step LEI apparatus. A novel technique was designed to couple flow‐injection analysis to a conventional LEI device; in this manner, electrical interference, a severe problem inherent in LEI, was successfully removed.
Liquid Chromatography with Pulsed Amperometric Detection for Speciation of Mercury
Authors: Hsi Tai‐Sung , Tsai Jian‐Shyun 
Published: May 2015

AbstractLiquid chromatography with pulsed amperometric detection (PAD) at an Au electrode was successfully applied for speciation of mercury: inorganic mercury, methylmercury and ethylmercury. The optimized conditions for triple‐step potential waveforms utilized in PAD were: E1 1800 mV, t1 50 ms; E2 300 mV, t2 3850 ms; E3 750 mV, t3 100 ms; mercury oxidation was monitored at E3. With the eluent of HClO4 (0.10 M) + KCl (1.0 mM) + CH3CN (1.0%) at a flow rate 0.80 mL/min, three mercury species were fully separated in 6 min on a glass column (3 mm × 10 cm) packed with Chemcosorb C18 (5 μm). However, the first peak (inorganic mercury) was commonly overlapped by the solvent front. The relative standard deviations (n = 6) for methylmercury (15 ppb) and ethylmercury (30 ppb) were 4.2% and 2.8%, respectively. The linear range tested was 2 – 500 ppb (r = 0.9998) for methylmercury, and was 4 – 1000 ppb (r = 1.000) for ethylmercury. The detection limits (S/N = 3) were 1.2 ppb and 1.8 ppb for methylmercury and ethylmercury, respectively. The results of determination of the mercury‐containing species thimerosat in three commercial contact‐lens solutions agreed satisfactorily with the expected values.
Microanalysis Using Secondary Ion Mass Spectrometry
Authors: Ling Yong‐Chien 
Published: May 2015

AbstractSecondary ion mass spectrometry (SIMS) has inherent features of high sensitivity, great dynamic range, and capability to provide spatially resolved chemical information making it well suited for trace and microanalysis of diverse materials. The various SIMS methods used to derive the boron distribution in hepatoma cells, to investigate the intcr‐iayer reactions in multi‐layer ceramic structural materials, and to evaluate the effects of fabrication on microstructural and functional properties in semiconductor devices, are presented to illustrate possible roles of SIMS in microanalysis.
Solvent Effect on Solvolytic Reactivities of 1‐Aryl‐2,2‐Dimethyl‐1‐Propyl Tosylates Containing Ortho‐Methyl Groups. Inconsistency between Theoretical Calculations and Experimental Results
Authors: Liu Kwang‐Ting , Tang Chung‐Shin , Chin Chien‐Pu 
Published: May 2015

AbstractSolvolyses of tosylates IIB and IIC in a variety of solvents were found to give excellent linear log k ‐YBnOTs plots (R = 0.997 and SD = 0.022) and negative ΔS≠ for IIB, but slight deviations (R = 0.987 and SD = 0.047) from lineation and positive ΔS≠ for several cases for IIC. Limiting SN1 mechanisms with steric hindrance to resonance and solvent intervention at the cationic transition state could thus be confirmed. The inconsistency between theoretical and observed trend of ΔH≠ is attributed to the neglect of solvent effect in MO calculations. Deductions linking theoretical calculation and solvolytic experiments should be drawn with caution.
Protease‐Catalyzed Peptide Synthesis: Basic Principles, New Synthesis Strategies and Medium Engineering
Authors: Jakubke Hans‐Dieter 
Published: May 2015

AbstractThe application of enzymes to perform selective transformations is the central aim of industrial biocatalysis. Since a simple handled C‐N ligase is not available, the only alternative of general practical interest for enzymatic peptide bond formation are proteases due to the principle of microscopic reversibility. The stereo‐ and regiospecifitity of proteases, which guarantee racemization‐free segment condensation and require only minimal side‐chain protection, are significant for preparative purposes. Unfortunately, proteases are not perfect acyltransferases. Both unwanted proteolytic side reactions and the hydrolysis of the acyl‐enzyme in the kinetic approach are the major problems in enzymatic peptide synthesis. The object of this paper was to demonstrate several new synthesis strategies including medium engineering that enables one to bypass unfavorable reaction routes. Planning and optimization of enzymatic peptide synthesis require the S′ subsite mapping of proteases and the knowledge of additional basic parameters that determine the reaction course.
Classical Trajectory Study of HF Desorption on LiF(001) Surface
Authors: Shiang Keh‐Dong 
Published: May 2015

AbstractWe report a classical trajectory study of the molecular desorption of a vibrationaly excited HF adsorbed on a corrugated LiF(001) surface. The desorption is induced by either a vibrational deexcitation of the adsorbed molecule (vibrational desorption) or an active motion of the surface ion (thermal desorption). A brief description of the calculation of the gas molecule/surface interaction potential is first presented. By applying this potential, Hamilton's equations of motion can be numerically integrated with the initial conditions selected, thus the dynamics is simulated. The result gives a clear indication about the features of the evolution of the vibrational, rotational and translational energies with increase of time. The angular momentum and translational energy distributions of the desorbed molecule are presented. Desorption probabilities for different initial states of the adsorbed molecule are also predicted, which are influenced by the polar‐angle‐dependent potential and the excitation of the initial vibrational level. The surface phonon mode is found to be strongly coupled to the vibrational, rotational, translational modes of the molecule and surface bond.
Effect of Temperature and Inhomogeneities on Binding of a Ligand to Haeme Proteins
Authors: Liao Dah‐Wei , Yang Dah‐Yen , Sheu Sheh‐Yi , Hayashi Michitoshi , Tang Chu‐Kang , Suzuki Satoru , Alden Rhett , Lin Sheng Hsien 
Published: May 2015

AbstractWe apply a quantum‐mechanical theory of rate processes to treat the recombination of ligands to haeme proteins such as myoglobin. Emphasis is placed on the effect of temperature in the low‐temperature regime.We present a theory of time‐resolved spectra pertaining to protein dynamics. We emphasize the analysis of the entire spectrum rather than spectral shifts as a function of time.
Capillary Zone Electrophoresis of Eleven Priority Phenols with Amperometric Detection
Authors: Chen I‐Chih , Whang Chen‐Wen 
Published: May 2015

AbstractA scheme for separation and detection of eleven priority phenols using capillary zone electrophoresis (CZE) coupled with amperometric detection is described. With a capillary of I.D. 50 μm and length 62.5 cm at 9 kV and an electrophoretic buffer of 20 mM CHES (pH 10.1), complete separation of the eleven compounds was achieved in less than 17 min. Amperometric detection was carried out using a carbon fiber microelectrode of diameter 9 μm inserted into the end of the detection capillary. Linearity over two orders of magnitude was generally obtained for the eleven priority phenols. With an electrode potential+1.10 V (vs. Ag/AgCl reference), the concentration limits of detection were in the sub‐ppm (10−6 M) level. This method was successfully applied to analysis of priority phenols in industrial waste water.
Synthesis and Crystal Structure of CpFe(CO)l(η1‐Ph2PCH2P(O)Ph2)
Authors: Hsu Ming‐Ann , Yeh Wen‐Yann , Peng Shie‐Ming , Lee Gene‐Hsiang 
Published: May 2015

AbstractCpFe(CO)I(η1‐Ph2PCH2P(O)Ph2) 2 was obtained in small yield from reaction of [CpFe(CO)]2[μ‐(Ph2P)2CH2] with diiodine in benzene, or prepared in 82% yield on treating CpFe(CO)I(η1‐Ph2PCH2PPh2) 1 with H2O2. Compound 2 crystallizes in the space group P21/n, with a = 8.441(2) Å, b = 10.054(2) Å, c = 33.343(8) Å, β = 92.33(2)°, Z = 4, V = 2827(1) Å3, RF = 0.057, and Rw = 0.056.
Multiple Enantioselection by an Enzyme‐Catalyzed Transacylation Reaction
Authors: Lin Gialih , Chen Show‐Jane , Sun Hwey‐Lin 
Published: May 2015

AbstractMultiply enantioselective enzyme‐catalyzed transacylation reactions are described. Two instances of triply enantioselective enzyme‐catalyzed transacylations are 1) the reaction of rac‐1‐indanol with rac‐1,1′‐bi‐2‐naphthy]‐2,2′‐dibutyrate to afford (S)‐1‐indanoL (R)‐1‐indanylacetate, (S)‐1,1′‐bi‐2‐naphthyl‐2,2′‐diol, and (R)‐1,1′‐bi‐2‐naphthyl‐2,2′‐dibutyrate and 2) the reaction of rac‐1‐indanol with rac‐2,2′‐bis(butyroxymethyl)biphenyl to afford (S)‐1‐indanol, (R)‐1‐indanylbutyrate, (S)‐2,2′‐biphenyldimethanol, and (R)‐2,2′‐bis(butyroxy‐methyl)biphenyl. Doubly enantioselective enzyme‐catalyzed transacylations are described according to two instances: 1) the reaction of rac‐1‐indanol with rac‐1,1′‐bi‐2‐naphthyl‐2‐ol‐2′‐butyrate afforded (S)‐1‐indanol, (R)‐1‐indanylacetate, (S)‐1,1′‐bi‐2‐naphthyl‐2,2′‐diol, and (R)‐1,1′‐bi‐2‐naphthyl‐2‐ol‐2′‐butyrate, and 2) the reaction of rac‐1‐indanol with 1,3,5‐O‐methylidne‐2,4,6‐tri‐O‐butyrate‐myo‐inositol to afford (S)‐1 ‐indanol, (R)‐l‐indanylbutyrate, and 1,3,5‐O‐methylidne‐2,6‐di‐O‐butyrate‐myo‐inositol. Multiply enantioselective enzyme‐catalyzed reactions have a merit of the enhancement of enantiomeric excess over singly enantioselective ones.
Asymmetric Reduction Using Lithium Aluminum Hydride Modified with Chiral Ligands Prepared from (1R)‐(‐)‐β‐Pinene
Authors: Lu Ta‐Jung , Liu Shew‐Wen 
Published: May 2015

AbstractThe reduction of prochiral ketones using chiral reducing reagents, prepared from lithium aluminum hydride and (‐)‐(1R, 2S, 3S, 5R)‐10‐anilinopinanediol (5) and (‐)‐(1R, 2S, 3S, 5R)‐10‐N‐methylanilinopinanediol (6), affords chiral secondary alcohols in useful chemical yields (70 ∼ 93%) but in low optical purity (8 ∼ 33% ee). Modifiers 5 and 6 are synthesized from (lR)‐(‐)‐β‐pinene in three steps.
Multiflorin, A New Secoiridold Lactone from Jasminum Multiflorum
Authors: Shen Ya‐Ching , Chen Chung‐Hsiung 
Published: May 2015

AbstractA new secoiridoid, multiflorin (1) has been isolated from the EtOAc‐soluble fraction of Jasminum multiflorum (Oleaceace). The structure of I was determined by application of spectral methods.
Synthesis and Chemistry of 4‐Aroyl‐3‐oxo‐ and 3‐Chloropyridazine Derivatives
Authors: Shalaby Alyaa A. , Youssef Ali M. , Youssef Wael A. , Shams Nabil A. 
Published: May 2015

Abstract4H,5H‐6‐Phenyl (1a) and 6‐p‐phenoxyphenyl (1b) pyridazin‐3(2H)‐ones were reacted with aromatic aldehydes to give 4‐arylmethylpyridazm‐3(2H)‐ones (2a‐g), Oxidation of (2a‐g) with various oxidising agents (selenium dioxide in ethanol or chromium trioxide in acetic acid) gave 4‐aroyl‐6‐arylpyridazin‐3(2H)‐ones (3a‐g). Chlorination of (3a‐g) with phosphorous oxychloride afforded 4‐aroyl‐6‐aryl‐3‐chloropyridazine (4a‐g). 1H‐3‐Aryl‐5‐phenylpyrazolo[3,4‐c]pyridazines (5a‐d) were obtained by heating (4a‐d) with excess hydrazine hydrate. Hydroxyamination of (3e‐g) with iydroxylamine gave aryl‐4(6‐p‐phenoxyphenyl‐2,3‐dihydro‐3‐oxo)pyridazinyl oxime (6a‐c). Silylation of oximes (6b & 6c) gave (7a & 7b) as acyclic compound instead of the expected seven ‐ membered ‐ ring compound (8).