bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer incidence in people with affective disorder: nationwide
cohort study in Taiwan, 1997–2010
Authors: Hung Yen-Ni , Yang Shu-Yu , Huang Ming-Chyi , Lung For-Wey , Lin Shih-Ku , Chen Kuan-Yu , Kuo Chian-Jue , Chen Ying-Yeh 
Published: June 2014

BackgroundCancer is a serious public health problem worldwide, and its relationship
with affective disorders is not clear.AimsTo investigate alcohol- and tobacco-related cancer risk among patients
with affective disorders in a large Taiwanese cohort.MethodRecords of newly admitted patients with affective disorders from January
1997 through December 2002 were retrieved from the Psychiatric Inpatient
Medical Claims database in Taiwan. Cancers were stratified by site and
grouped into tobacco- or alcohol-related cancers. Standardised incidence
ratios (SIRs) were calculated to compare the risk of cancer between those
with affective disorders and the general population.ResultsSome 10 207 patients with bipolar disorder and 9826 with major depression
were included. The risk of cancer was higher in patients with major
depression (SIR = 2.01, 95% CI 1.85–2.19) than in those with bipolar
disorder (SIR 1.39, 95% CI 1.26–1.53). The elevated cancer risk among
individuals ever admitted to hospital for affective disorders was more
pronounced in tobacco- and/or alcohol-related cancers.ConclusionsElevated cancer risk was found in patients who had received in-patient
care for affective disorders. They require holistic approaches to
lifestyle behaviours and associated cancer risks.
The SMRT Coregulator Enhances Growth of Estrogen Receptor-α-Positive Breast Cancer Cells by Promotion of Cell Cycle Progression and Inhibition of Apoptosis
Authors: Blackmore Julia K. , Karmakar Sudipan , Gu Guowei , Chaubal Vaishali , Wang Liguo , Li Wei , Smith Carolyn L. 
Published: June 2014

Abstract
The SMRT coregulator functions as a dual coactivator and corepressor for estrogen receptor-α (ERα) in a gene-specific manner, and in several studies its elevated expression correlates with poor outcome for breast cancer patients. A specific role of SMRT in breast cancer progression has not been elucidated, but SMRT knock-down limits estradiol-dependent growth of MCF-7 breast cancer cells. In this study, small-interfering RNA (siRNA) and short-hairpin RNA (shRNA) approaches were used to determine the effects of SMRT depletion on growth of ERα-positive MCF-7 and ZR-75–1 breast cancer cells, as well as the ERα-negative MDA-MB-231 breast cancer line. Depletion of SMRT inhibited growth of ERα-positive cells grown in monolayer but had no effect on growth of the ERα-negative cells. Reduced SMRT levels also negatively impacted the anchorage-independent growth of MCF-7 cells as assessed by soft agar colony formation assays. The observed growth inhibitions were due to a loss of estradiol-induced progression through the G1/S transition of the cell cycle and increased apoptosis in SMRT-depleted compared with control cells. Gene expression analyses indicated that SMRT inhibits apoptosis by a coordinated regulation of genes involved in apoptosis. Functioning as a dual coactivator for anti-apoptotic genes and corepressor for pro-apoptotic genes, SMRT can limit apoptosis. Together these data indicate that SMRT promotes breast cancer progression through multiple pathways leading to increased proliferation and decreased apoptosis.
Functional Characterization of Obesity-Associated Variants Involving the α and β Isoforms of Human SH2B1
Authors: Pearce Laura R. , Joe Ray , Doche Michael E. , Su Hsiao-Wen , Keogh Julia M. , Henning Elana , Argetsinger Lawrence S. , Bochukova Elena G. , Cline Joel M. , Garg Sumedha , Saeed Sadia , Shoelson Steven , O'Rahilly Stephen , Barroso Inês , Rui Liangyou , Farooqi I. Sadaf , Carter-Su Christin 
Published: June 2014

Abstract
We have previously reported rare variants in sarcoma (Src) homology 2 (SH2) B adaptor protein 1 (SH2B1) in individuals with obesity, insulin resistance, and maladaptive behavior. Here, we identify 4 additional SH2B1 variants by sequencing 500 individuals with severe early-onset obesity. SH2B1 has 4 alternatively spliced isoforms. One variant (T546A) lies within the N-terminal region common to all isoforms. As shown for past variants in this region, T546A impairs SH2B1β enhancement of nerve growth factor-induced neurite outgrowth, and the individual with the T546A variant exhibits mild developmental delay. The other 3 variants (A663V, V695M, and A723V) lie in the C-terminal tail of SH2B1α. SH2B1α variant carriers were hyperinsulinemic but did not exhibit the behavioral phenotype observed in individuals with SH2B1 variants that disrupt all isoforms. In in vitro assays, SH2B1α, like SH2B1β, enhances insulin- and leptin-induced insulin receptor substrate 2 (IRS2) phosphorylation and GH-induced cell motility. None of the variants affect SH2B1α enhancement of insulin- and leptin-induced IRS2 phosphorylation. However, T546A, A663V, and A723V all impair the ability of SH2B1α to enhance GH-induced cell motility. In contrast to SH2B1β, SH2B1α does not enhance nerve growth factor-induced neurite outgrowth. These studies suggest that genetic variants that disrupt isoforms other than SH2B1β may be functionally significant. Further studies are needed to understand the mechanism by which the individual isoforms regulate energy homeostasis and behavior.
Pharmacological Inhibition of Myostatin and Changes in Lean Body Mass and Lower Extremity Muscle Size in Patients Receiving Androgen Deprivation Therapy for Prostate Cancer
Authors: Padhi Desmond , Higano Celestia S. , Shore Neal D. , Sieber Paul , Rasmussen Erik , Smith Matthew R. 
Published: June 2014

Abstract

Context:
Myostatin is a negative regulator of muscle growth. Androgen deprivation (ADT) is associated with muscle loss and increased body fat, and currently available therapies have limited efficacy to treat this complication. The antimyostatin peptibody (AMG 745/Mu-S) markedly attenuated muscle loss and decreased fat accumulation in orchiectomized mice.

Objective:
The objective of the study was to evaluate the safety, pharmacokinetics, and muscle efficacy of AMG 745 in men undergoing ADT for nonmetastatic prostate cancer.

Methods:
This was a randomized, blinded, placebo-controlled, multiple-dose, phase 1 study of AMG 745 given for 28 days. The end point of percentage change from baseline in lean body mass (LBM) as assessed by dual x-ray absorptiometry was prespecified.

Results:
Rates of adverse events (AMG 745 vs placebo) were the following: diarrhea (13% vs 9%), fatigue (13% vs 4%), contusion (10% vs 0%), and injection site bruising (6% vs 4%). Exposure increased linearly from 0.3 mg/kg to 3 mg/kg. AMG 745 significantly increased LBM in the 3 mg/kg vs the placebo groups on day 29 by 2.2% (±0.8% SE, P = 0.008); in exploratory fat mass analysis, a decrease of −2.5% (±1.0% SE, P = 0.021) was observed. Pharmacodynamic changes in muscle and fat were maintained at follow-up, 1 month after day 29.

Conclusion:
Four weekly sc doses of AMG 745 were well tolerated and were associated with increased LBM and decreased fat in the men receiving ADT for nonmetastatic prostate cancer. Results support further investigation of AMG 745 in clinical settings with muscle loss and atrophy.
Photoresponsive Modulation of Mass Transfer through Spiropyran-grafted Anodized Aluminum Oxide Membrane
Authors: Park Young Ho , Jeong Chan Jin , Park Chan Pil , Park Sung Young , In Insik 
Published: June 2014

Abstract
Photoresponsive anodized aluminum oxide (AAO) membrane was prepared through mussel-inspired functionalization of poly(ethylene glycol) conjugated with both spiropyran and catechol moieties. Reversible modulation of water-transfer rate through spiropyran-enriched AAO membrane was demonstrated along with photoisomerization of spiropyran groups on the membrane through “wettability”-controlled mechanism.
Notes on the typification and nomenclature of Salsola and Kali (Chenopodiaceae)
Authors: Akhani Hossein , Greuter Werner , Roalson Eric H. 
Published: June 2014

AbstractThe origin of the generic names Salsola L. and Kali Mill. is discussed. The latter is a legitimate name, published independently from Salsola, even though the original generic boundaries are by and large the same. The type of Salsola is S. soda L., the earliest to have been designated in a non‐supersedable way. The type of Kali is S. kali L. (K. soda Moench non (L.) Scop.; = K. turgidum (Dumort.) Guterm.). The current nomenclatural situation is satisfactory and need not be changed by any conservation proposal.
New combinations and names in Melaleuca (Myrtaceae)
Authors: Craven Lyn A. , Edwards Robert D. , Cowley Kirsten J. 
Published: June 2014

AbstractThe taxonomy of Melaleuceae has been re‐assessed in the light of DNA sequence studies and it is concluded that all genera should be placed within Melaleuca. Beaufortia, Calothamnus, Conothamnus, Eremaea, Lamarchea, Petraeomyrtus, Phymatocarpus and Regelia and their constituent species are formally transferred to Melaleuca. One hundred and six nomenclatural changes are provided of which 72 are new combinations and 34 are new names.
Notes concerning the nomenclature of Polypodium ptiloton and its correct spelling in Pecluma
Authors: Assis Francine C. , Zimmer Brigitte 
Published: June 2014

AbstractThe correct spelling of the species usually referred to as Pecluma “ptilodon” or Polypodium “ptilodon” is Pecluma ptilota (Kunze) M.G.Price (Polypodium ptiloton Kunze). The history of the name, its etymology, and its correct spelling are discussed below.
Andropogoneae versus Sacchareae (Poaceae: Panicoideae): The end of a great controversy
Authors: Welker Cassiano A.D. , Kellogg Elizabeth A. , Prado Jefferson 
Published: June 2014

AbstractThe grass tribe Andropogoneae includes plants of great economic importance, such as maize, sugarcane, sorghum, and others. Recent works have questioned the use of the name Andropogoneae Dumort. (1824) for the tribe and have suggested erroneously that the correct name should be Sacchareae Martinov (1820). However, Martinov's name was not published at the rank of tribe. Therefore, it does not threaten the well‐established name Andropogoneae. In this paper we lay out the basis for the controversy and the rationale for continued use of the name Andropogoneae.
On the application of the Linnaean names Cucubalus reflexus, Silene nocturna and Silene mutabilis (Caryophyllaceae)
Authors: Peruzzi Lorenzo , Jarvis Charles E. , Carta Angelino 
Published: June 2014

AbstractThe application of the names Cucubalus reflexus and Silene nocturna is revised and discussed while, for the name S. mutabilis, a specimen in LINN (Herb. Linnaeus) is designated as lectotype. It is concluded that S. nocturna, which is based on cultivated material, correctly matches its current application. Silene reflexa is a heterotypic synonym of S. nocturna subsp. capraria. Finally, the name S. mutabilis is applicable to the taxon currently known as S. neglecta Ten., and the Linnaean name is therefore the earliest name for this species.
Typification of Merino's names in Leguminosae
Authors: Pino Pérez Rubén , Silva-Pando Francisco Javier , Pino Pérez Juan José 
Published: June 2014

AbstractThirty‐nine lectotypes (one second‐step), four neotypes and one epitype stemming from 66 Merino non‐typified names of plants belonging to the family Leguminosae are designated. One previous lectotypification is modified.
Narratives of dancers: Somatic and artistic practices of a Canadian and a Brazilian dancer
Authors: Dantas Mônica Fagundes , da Silva Suzane Weber 
Published: June 2014

Abstract
This article discusses the intersections of the artistic practice and somatic education in the work of a Canadian and a Brazilian dancer within the complex negotiation among body, society, and dance. We will base our analysis on narratives collected in two case studies, one by Pamela Newell in Montreal and one by Marcela Levi in Rio de Janeiro. The aesthetic consequences of incorporating somatics arise in the plasticity of gestures and body. But this incorporation is seen in relation to the operational aspects of creation, such as the elasticity of roles from the dancer to the choreographer, and from the collaborator to the viewer. Thus, these relations concern the political order of the scene and promote a less directive sociability of the performing arts.
LandMark: Dance as a site of intertwining
Authors: Carr Jane 
Published: June 2014

Abstract
In the performance installation, LandMark (2011), dancers Deborah Saxon and Henry Montes and the visual artist Bruce Sharp explore both the facticity of human experience and the frailty of connections between people and between them and the world that they inhabit.1 I suggest that their work may also be understood to probe the complexities of the interrelationships between consciousness-world and self-other that are the focus of Maurice Merleau-Ponty’s text, ‘The intertwining-the chiasm’. His analysis of intercorporeality is particularly relevant to understanding the significance of the dancers’ somatic investigations that inform their artistic practices. Further, by drawing on developments upon Merleau-Ponty’s work in ecological aesthetics and social philosophy, I explore how the artists’ creative practices may be understood to foster intercorporeal negotiations of significance. This is suggested to be of increasing importance within an intracultural context in which people have a complex variety of cultural experiences even while sharing in a national identity.
Teaching fundamentals of modern dance in Mali, an on-going learning exchange
Authors: Greene Lila 
Published: June 2014

Abstract
This article addresses the question of the universality of somatic approaches in teaching dance through the author’s experiences in Mali. She describes how context is an important part of the teaching–learning experience in a cross-cultural situation. While it might be said that the body is a constant, the context (the cultural interpretation) is not. A dancer evolves first in a dominant ‘homeland’ cultural context. With somatic-influenced teaching, a dancer can learn what is common to all human bodies and what is unique in his or her own. The author includes an interview with one of the dancers who is part of the programme in Mali. The respect of the individual in somatic approaches opens possibilities for exploration and shared understanding between people of very different backgrounds. In the best of circumstances, somatic work itself continues to evolve in an ever-changing landscape of learning exchanges.
Shaping experience in dance: Perspectives on body–mind relationships in Odissi
Authors: Catalano Elena 
Published: June 2014

Abstract
The article examines somatic experience in Odissi, arguing that this is shaped by the dance’s techniques of transmissions and aesthetic values. In particular, the article discusses how certain practices and discourses enable, hinder or give meaning to different experiences of body–mind relationships in Odissi dance. It is suggested that somatic experience in Odissi is characterized by a tension between training and performance. This tension is explained in terms of different forms of consciousness.
As muitas invenções da EJA
Authors: Sales Sandra Regina , Paiva Jane 
Published: June 2014

Usando os processos de modelagem de pessoas de Ian Hacking recontamos as invenções da educação popular e da EJA pela perspectiva de compreender quem é e como se formaram os sistemas de classificação dos sujeitos. Em um segundo momento, estabelecemos um diálogo crítico entre a noção de modelagem com os aprendizados do tempo presente, identificados nos trabalhos que compõem o segundo Dossiê de EJA na EPAA, destacando os movimentos de investigação que os pesquisadores-autores desenvolveram; as epistemologias; as metodologias de conhecimento utilizadas no campo da EJA, sintetizando o que as pesquisas revelam sobre as muitas invenções dos sujeitos da EJA. Em última instância, queremos destacar os aprendizados, e o que ainda teríamos que aprender para que os pesquisadores da EJA possam intervir efetivamente nos múltiplos contextos brasileiros e latino-americanos no sentido da transformação social.
Trabalho, Educação e Emancipação Humana: A Afirmação da EJA como Direito
Authors: Fischer Maria Clara Bueno , Godinho Ana Cláudia Ferreira 
Published: June 2014

Este artigo aborda a Educação de Jovens e Adultos (EJA) no Brasil como direito e como campo, com práticas e reflexões de matrizes político-pedagógicas distintas ou mesmo antagônicas. Tais reflexões inserem-se no debate sobre os fundamentos e modalidades da relação entre educação, trabalho e emancipação humana. Uma ideia força do texto é a convicção de que pessoas jovens e adultas são sujeitos de direitos e que a plena realização de um deles – o acesso e permanência na escola – depende do (re)conhecimento, por todos aqueles que estão envolvidos no campo, da natureza e do potencial da relação desses sujeitos com os mundos do trabalho. Neste estudo de natureza qualitativa, as autoras realizaram análise documental e retomaram dados de duas pesquisas qualitativas em Educação, que coletaram dados por meio de entrevistas individuais semiestruturadas, observação participante e registro em diário de campo. Argumentou-se sobre a centralidade da experiência singular e coletiva do aluno-trabalhador para mediar relações entre trabalho e educação no currículo da EJA. As autoras enfatizam o trabalho como lugar de produção, mobilização e (re)interpretação permanente de saberes e valores pelos trabalhadores. Estes, ao ingressarem em cursos de EJA, colocam em circulação no contexto escolar estes saberes e valores produzidos no mundo do trabalho, gerando tensionamentos que impelem a reaproximação entre saberes escolares e experiência de trabalho. As autoras ressaltam a pertinência de novos estudos sobre o Currículo Integrado e outras práticas curriculares que valorizem o trabalho enquanto experiência humana.
Measuring Freeze and Thaw Damage in Mortars Containing Deicing Salt Using a Low-Temperature Longitudinal Guarded Comparative Calorimeter and Acoustic Emission
Authors: Farnam Yaghoob , Bentz Dale , Sakulich Aaron , Flynn Daniel , Weiss Jason 
Published: June 2014

Abstract
Deicing salts are often applied to the surface of pavements and bridge decks in the winter to melt ice, thereby improving safety for the traveling public. In this paper, the influence of NaCl deicing salt on freezing and thawing temperatures of pore solution and corresponding damage of mortar specimens were investigated. A low-temperature longitudinal guarded comparative calorimeter (LGCC) was developed to cool down a mortar sample at a rate of 2°C/h and to re-heat the mortar at a rate of 4°C/h. Heat flux during freezing and thawing cycles was monitored, and the temperatures at which freezing and thawing events occurred were detected. During cooling and heating, acoustic emission (AE) activity was measured to quantify the damage (cracking) caused by aggregate/paste thermal mismatch and/or phase changes. The results show that NaCl solution in a mortar sample freezes at a lower temperature than the value expected from its bulk phase diagram because of under-cooling. Conversely, the frozen solution in mortar melts at the same melting temperature as the bulk frozen NaCl solution. As the salt concentration increases, the freezing temperature is lowered. For samples containing more highly concentrated solutions, an additional exothermic event is observed whose corresponding temperature is greater than the aqueous NaCl liquidus line in the phase diagram. Damage also begins to occur at this temperature. For mortar samples saturated by solutions with 5 % and 15 % NaCl by mass, greater freeze/thaw damage is observed. The AE calorimeter developed herein is applicable for investigating damage behavior during freezing and thawing of different phases in pore solution (in mortars).
The Role of Concrete Industry Standards as Institutional Barriers to More Sustainable Concrete Bridge Infrastructure
Authors: Arbuckle Peter W. , Lepech Michael D. , Keoleian Gregory A. 
Published: June 2014

Abstract
The concrete construction industry is governed by a network of codes and standards that ensure safety and quality. This study evaluates two central concrete construction industry standards related to bridge construction to determine if these standards inhibit more sustainable concrete bridge construction. Using social networking tools, ASTM C150-05: Standard Specification for Portland Cement and American Concrete Institute (ACI) 211.1-91/09 Standard Practice for Proportioning Normal, Heavyweight, and Mass Concrete, were identified as “central” concrete industry standards and were evaluated to test whether central concrete industry standards pose institutional barriers to innovation for sustainable concrete construction. Results indicate that while these standards do not explicitly inhibit more sustainable concrete practice, the manner in which they are used implicitly impedes more sustainable concrete construction and innovation for sustainability. Specifically, ASTM C150-05 does not inhibit the use of cement materials with lower environmental impact, but industry demand for rapid construction and institutionalized use of C150-05 to the exclusion of other environmentally preferable products does inhibit more sustainable concrete construction. Similarly, mixes designed for durability using performance-based specifications exhibit reduced annual energy and material impacts compared to mixtures traditionally designed using ACI 211.1-91/09.
Strain Gradients in Concrete Affected by Alkali–Silica Reaction: A Laboratory Simulation
Authors: Giannini Eric R. , Bentivegna Anthony F. , Folliard Kevin J. 
Published: June 2014

Abstract
Alkali–silica reaction (ASR) is a significant durability issue that has resulted in expansion and cracking of numerous concrete structures. Expansion is often not uniform in a given structure, leading to the development of strain gradients and manifested in macrocracking patterns on the surface. Techniques developed to mitigate ASR in existing structures involving surface treatments, such as lithium impregnation or silanes, can cause strain gradients to develop by suppressing expansion in the near-surface region, while expansion in the center of the concrete continues uninhibited. A set of plain concrete slabs consisting of a layer of ASR-resistant concrete with lithium nitrate admixture cast over a layer of ASR-susceptible concrete were monitored for expansion and crack development. The study found that a layer of ASR-resistant concrete of at least 50 mm (2.0 in.) deep was necessary to significantly suppress expansion and cracking at the top surface. However, in all layered specimens, the bottom layer continued to expand and a significant strain gradient developed between the top and bottom surfaces.
Stribeck-Type Curves of Alternative Engine Oils: Part I: Gray Cast Iron Liners
Authors: Woydt Mathias , Kelling Norbert , Hannemann Falk , Berberich Niklas , Ziegele Holger 
Published: June 2014

Abstract
Wear tests are often used in engine development in order to characterize the functional profile of surfaces interacting with lubricants. This paper proposes a new test procedure to determine Stribeck-type curves for the tribosystem piston ring/cylinder liner involving test pieces prepared from engine components. The variation of the friction coefficient with sliding speed depends on the structure and constitution of the base oil, the viscosity index, the surface topography of the liner and ring, and the friction modifiers used. Novel organic friction modifiers of low molecular mass not only reduce the friction coefficients under mixed / boundary lubrication, but also in the fluid film regime. In addition, the influence of surface roughness on the wettability of surfaces can be significant for both static and dynamic wetting. For this reason, the interaction of the lubricant with the surfaces was also investigated to enable a correlation between the surface properties of the liquid and solid phases and the tribological behavior.