bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling voluntary CAAT utilization decisions in auditing
Authors: B. Curtis Mary , A. Payne Elizabeth 
Published: April 2014

Purpose
– The authors aim to examine whether the well-established unified theory of acceptance and use of technology can be effectively adapted for use in an external audit setting and whether the re-specified model holds under different levels of budget pressure.

Design/methodology/approach
– This paper takes the form of a case study/questionnaire with Lisrel path modelling.

Findings
– Results support the re-specified model.

Research limitations/implications
– The model should aid audit research by providing a platform for new research to explore more specific solutions to technology reluctance. The authors extend general TAM research through additional exploration of the theory and impact of social influence, a determinant that has shown inconsistent tendencies in prior studies. The authors address several limitations in past TAM research including the use of student participants and self-selection bias.

Practical implications
– Firms must understand the implications of their policies and culture on the intention of audit teams to voluntarily utilize software. Technology can improve the efficiency and effectiveness of audit procedures, aid in the identification of fraud and lower litigation costs. Accounting firms have invested in the development of audit testing software and can only recoup these investments if the software is used.

Originality/value
– The study is the first to completely model the intention to use technology in an external audit engagement with consideration of budget influences.
Innovation in procurement from rural India using enterprise mobility strategy: a case study
Authors: Shah Mrinalini , Chattopadhyay Nilanjan 
Published: April 2014

Purpose
– The fundamental rule for sustenance in the business world for organizations is to explore new ways to discover themselves and to realign the business strategies with the changing environment, apply new management concepts and adopt new technologies so as to have a faster response to the changing business situation. With more than 600 million user base of mobile phones in India, it may be useful for the Indian companies to set up an enterprise mobility strategy akin to their information technology strategy and take maximum advantage of this mobile wave. The paper aims to discuss these issues.

Design/methodology/approach
– The paper discusses methodology adopted to bring in and manage change in its process of procurement in a big organization “Marico,” one of the largest players in the Indian FMCG sector. A detailed process which “Marico” adopted to bring change in procurement process and its supply chain was studied with the help of long interviews and available secondary data.

Findings
– Heindl mode (2008) on the steps on continuous innovation are what Marico followed though process started in Marico much earlier. The case emphasizes how innovation models can be followed even to bring change in big corporate houses.

Practical implications
– Marico did formulate an enterprise mobility strategy as an innovation in its procurement process can pave the way and learning for other FMCG companies to benchmark its strategies against the one adopted by “Marico” the company of the study to find out the gaps exiting and therefore, the scope for improvement.

Originality/value
– “Maricio” is a unique example of continuous innovation and change in procurement from rural India which revolutionized the industry and bought bigger revenue and less hassles for the company.
The determinants of ASEAN-5 real effective exchange ratevis-á-visthe UK pound
Authors: AbuDalu Abdalrahman , Musa Ahmed Elsadig 
Published: April 2014

Purpose– The purpose of this paper is to present an empirical analysis of long-run and short-run forcing variables of purchasing power parity (PPP) for ASEAN-5 currenciesvis-à-visthe UK pound, i.e. their real effective exchange rate (REER).Design/methodology/approach– This study uses a recently developed autoregressive distributed lag (ARDL) approach to co-integration (Pesaranet al., 2001) over the period 1991:Q1-2006:Q2. Our empirical results suggest that the foreign interest rate (R*) and domestic money supply (M1) are the significant long-run forcing variables of PPP for ASEAN-5 REERs for the three periods.Findings– In the short-run, the variables have different impacts during the sub-periods and full period for ASEAN-5 countries. The results suggest that the domestic money supply (M1) for Malaysia, domestic interest rate and foreign interest rate (R*) for Indonesia, domestic money supply (M1) and term of trades (TOT) for Philippines, foreign interest rate (R*) for Thailand, and foreign interest rate (R*) and net foreign assets (NFA) for Singapore, respectively, have the highest significant short-run forcing variable of PPP for countries REERs.Originality/value– In this respect, the outcomes can derive policy implication for the monetary authorities in these ASEAN-5 countries.
Double parameterized regularization inversion method for migration velocity analysis in transversely isotropic media with a vertical symmetry axis
Authors: Yu Caixia , Wang Yanfei , Zhao Jingtao , Wang Zhenli 
Published: April 2014

ABSTRACTSimultaneous estimation of velocity gradients and anisotropic parameters from seismic reflection data is one of the main challenges in transversely isotropic media with a vertical symmetry axis migration velocity analysis. In migration velocity analysis, we usually construct the objective function using the l2 norm along with a linear conjugate gradient scheme to solve the inversion problem. Nevertheless, for seismic data this inversion scheme is not stable and may not converge in finite time. In order to ensure the uniform convergence of parameter inversion and improve the efficiency of migration velocity analysis, this paper develops a double parameterized regularization model and gives the corresponding algorithms. The model is based on the combination of the l2 norm and the non‐smooth l1 norm. For solving such an inversion problem, the quasi‐Newton method is utilized to make the iterative process stable, which can ensure the positive definiteness of the Hessian matrix. Numerical simulation indicates that this method allows fast convergence to the true model and simultaneously generates inversion results with a higher accuracy. Therefore, our proposed method is very promising for practical migration velocity analysis in anisotropic media.
Effects of selective harvest of non‐lactating females on chamois population dynamics
Authors: Rughetti Marco , Festa‐Bianchet Marco 
Published: April 2014

SummaryIn large mammals, regulations or hunter preference often lead to selective harvest of non‐lactating females, with unknown impacts upon population growth. Because female survival has very high elasticity effects on population growth, an assessment of the magnitude and selectivity of female harvest is crucial to understand population dynamics of sport‐hunted ungulates. Hunting accounts for most mortality of adult chamoisRupicapra rupicapraand regulations typically discourage the harvest of lactating females as orphaned kids have reduced survival rates.We used an individual‐based model, produced from empirical data, to explore the effects of selective removal of non‐lactating females on chamois population dynamics.Harvest intensity had much stronger effects on female population dynamics than selectivity for reproductive status. Selective harvest of non‐lactating females had very weak effects on population size and then only at a high harvest rate and under strong selectivity. Assuming no difference in winter survival between orphaned and non‐orphaned kids, harvest of non‐lactating females decreased population size at equilibrium compared to a random female harvest, whereas the opposite was true when assuming 50% lower survival of orphaned kids.Selective harvest of non‐lactating females may avoid the negative effects of orphaning on juvenile survival, but increases mortality of pre‐reproductive females that normally enjoy high survival and have high reproductive value.Synthesis and applications. The impact of selective harvest of non‐lactating females upon population dynamics is likely to be more affected by the age structure of lactating and non‐lactating females rather than by the survival of orphan and non‐orphan juveniles. High harvest of pre‐reproductive females has undesirable effects on population dynamics, which must be considered alongside any cultural preferences of hunters when developing hunting regulations or policies.
The need to address poor numeracy skills in the emergency department environment
Authors: Eley Robert , Sinnott Michael , Steinle Vicki , Trenning Leeanne , Boyde Mary , Dimeski Goce 
Published: April 2014

AbstractSubstantial evidence exists for lack of numerical skills among many health professionals. Although poor numeracy has long been recognised as a contributor to medication error, other activities for which numerical literacy are required, such as interpretation of diagnostic results, have been largely ignored. Poor self‐awareness of lack of numerical literacy increases the risk, especially in the busy and hurried emergency environment. System changes, such as standardising units and improving number presentation, reduce the potential for misinterpretation; however system changes do not address the underlying deficiencies in mathematical skills. The training of doctors in numeracy has been largely ignored. In contrast, education for nurses frequently occurs during both pre‐ and post‐registration programmes. Interventions have had mixed success, although additional emphasis in increasing conceptual understanding of numbers is encouraging. The consequences of poor numerical literacy should be addressed in all clinical staff, not only by practice change to remove the potential for errors to be made, but also complemented by self‐awareness and education.
Psychological factors in emergency medicine
Authors: Gutenstein Marc 
Published: April 2014

AbstractHuman psychology, neuroscience and behavioural economics study the human mind, brain and behaviour. Scientific research has discovered a great deal about the factors that influence human perception, judgment and activity in the real world. In this article, I aim to provide an outline of the relationship between decision‐making, cognition, emotion and behaviour. I propose that meta‐cognition, or thinking‐about‐thinking, has the potential to inform how we practice emergency medicine. By accommodating human traits rather than trying to defy them, we can ultimately benefit our patients.
Transporting children with toxicological emergencies
Authors: Blake Danielle , Dalton Sarah , Gunja Naren 
Published: April 2014

AbstractObjectiveEach year, the Newborn and Paediatric Emergency Transport Service (NETS) receives over 3600 calls from health professionals regarding the management and transportation of critically ill children across New South Wales, with toxicological emergencies making up 1.5% of these calls. The aim of the present study is to describe the characteristics of patients transported for toxicological emergencies and their retrieval management.MethodsA retrospective review of patients referred for management of a toxicological emergency between 2007 and 2011. Extracted data included patient demographics, substances involved, consultation with toxicological expertise, interventions performed and major adverse outcomes.ResultsTwo hundred and thirty patients, with 307 toxicological exposures, were referred to NETS, of whom 169 (73.5%) were subsequently transported. Pharmaceutical poisonings (223, 72.6%) were the most common, followed by non‐pharmaceutical poisonings (61, 19.9%) and envenomation (23, 7.5%). Psychotropics, analgesics and chemicals were the most frequently ingested substances. The most common source of accidentally ingested pharmaceuticals was a family member. The most frequently given therapies were specific antidotes, in particular naloxone and N‐acetylcysteine. Nearly half (43.2%) of transported children required only non‐invasive monitoring. There was one death during the retrieval process.ConclusionsMany children with toxicological emergencies require only non‐invasive monitoring, which could be provided by trained ambulance crews in select scenarios. Involvement of a toxicologist in the initial consultation to identify these patients might reduce retrieval numbers and costs. Children on regular medication and those living with family members on psychotropic or cardiac drugs were identified as high‐risk groups that should be targeted for medication safety education.
Semi‐subsistence Farming in Romania and Bulgaria: a Survival Strategy?
Authors: Hubbard Carmen , Mishev Plamen , Ivanova Nedka , Luca Lucian 
Published: April 2014

SummaryBulgaria and Romania have experienced radical transformations in their agriculture and rural economies, following transition to a market economy and accession to the EU. However, they remain two EU Member States characterised by a highly fragmented and polarised farm structure. The majority of farms in Bulgaria and Romania are very small in size. However, they continue to provide the main source of income for many rural households. They act as a social safety net and ensure food self‐sufficiency for both themselves and their urban relatives. There are other roles that small and SSFs appear to play in the wider rural economy, e.g. providers of environmental public goods, supplying speciality foods and ensuring the continuation of local and cultural traditions, but so far there is little research to support this argument. Despite the expectation of a gradual disappearance of small and SSFs and/or their market integration following the countries accession to the EU, it is clear that they are here to stay. At least for a while.
Narratives in research: Story as ‘showing’ the eminently ordinary experience of ageing
Authors: Wright‐St Clair Valerie A , Grant Bevan C , Smythe Elizabeth A 
Published: April 2014

AimTo offer a perspective when research narratives about how ageing is lived in everyday life are the primary data.MethodsA literature search explored the garnering of narratives about everyday life in advanced age in qualitative research. Narrative examples from the authors' research, and supervised student research, are drawn on to illustrate the experiences of ageing when going about an ordinary day.ResultsStories show the lived experience of ageing is both ordinary and complex. Notions revealed are: age as constructed, as assumed by others, as being engaged every day, and as living the day my way.ConclusionUnderstanding what it means to be older is in part shaped by which stories are told, who tells the stories and what sense is made of them. In gerontology research, ‘story telling’ can be a potent means of knowing what it means to be ‘older’ and of being worthy to self and others.
The use of vemurafenib in Australian patients with unresectable or metastatic melanoma containing the V600 BRAF gene mutation
Authors: Brown Michael P , Long Georgina V 
Published: April 2014

AbstractMetastatic melanoma remains one of the major causes of death related to skin cancers and has been resistant to traditional anticancer therapies. The clinical development of vemurafenib in the treatment of metastatic melanoma with the V600 mutation of the BRAF gene has provided meaningful improvements in the overall survival and progression‐free survival of metastatic melanoma patients. However, significant side effects have been noted with this therapy, in particular cutaneous adverse events (AEs) such as rashes, squamous cell carcinoma and severe photosensitivity to UVA light among others. With an emphasis on the Australian perspective, this review provides an overview of the clinical development of vemurafenib, its attendant dose‐limiting toxicities and other AEs, recommendations for safety monitoring, supportive treatments of AEs and dose modifications, with the aim of maximizing the chances of continuing beneficial treatment.
Determination of the net energy content of canola meal from Brassica napus yellow and Brassica juncea yellow fed to growing pigs using indirect calorimetry
Authors: Heo Jung Min , Adewole Deborah , Nyachoti Martin 
Published: April 2014

AbstractThe net energy (NE) content of canola meals (CM; i.e. Brassica napus yellow and Brassica juncea yellow) in growing pigs was determined using an indirect calorimetry chamber or published prediction equations. The study was conducted as a completely randomized design (n = 6), with (i) a basal diet and (ii) 2 diets containing 700 g/kg of the basal diet and 300 g/kg of either of the two varieties of CM. A total of 18 growing barrows were housed in metabolism crates for the determination of digestible (DE) and metabolizable (ME) energy. Thereafter, pigs were transferred to the indirect calorimetry chamber to determine heat production (HP). The NE contents of diets containing Brassica napus yellow and Brassica juncea yellow determined with the direct determination technique and prediction equations were 9.8 versus 10.3 MJ/kg dry matter (DM) and 10.2 versus 10.4 MJ/kg DM, respectively. Retained energy (RE) and fasting heat production (FHP) of diets containing Brassica napus yellow and Brassica juncea yellow were 5.5 versus 5.7 MJ/kg and 4.3 versus 4.5 MJ/kg, respectively, when measured with the direct determination technique and prediction equations. The NE contents of Brassica napus yellow and Brassica juncea yellow were determined to be 8.8 and 9.8 MJ/kg DM, respectively, using the direct determination technique.
Role of oocyte‐derived paracrine factors in follicular development
Authors: Emori Chihiro , Sugiura Koji 
Published: April 2014

AbstractMammalian oocytes secrete transforming growth factor β (TGF‐β) superfamily proteins, such as growth differentiation factor 9 (GDF9), bone morphogenetic protein 6 (BMP6) and BMP15, and fibroblast growth factors (FGFs). These oocyte‐derived paracrine factors (ODPFs) play essential roles in regulating the differentiation and function of somatic granulosa cells as well as the development of ovarian follicles. In addition to the importance of individual ODPFs, emerging evidence suggests that the interaction of ODPF signals with other intra‐follicular signals, such as estrogen, is critical for folliculogenesis. In this review, we will discuss the current understanding of the role of ODPFs in follicular development with an emphasis on their interaction with estrogen signaling in regulation of the differentiation and function of granulosa cells.
Molecular Dynamics of Interactions between Rigid and Flexible Antifolates and Dihydrofolate Reductase from Pyrimethamine‐Sensitive and Pyrimethamine‐Resistant Plasmodium falciparum
Authors: Mokmak Wanwimon , Chunsrivirot Surasak , Hannongbua Supa , Yuthavong Yongyuth , Tongsima Sissades , Kamchonwongpaisan Sumalee 
Published: April 2014

Currently, the usefulness of antimalarials such as pyrimethamine (PYR) is drastically reduced due to the emergence of resistant Plasmodium falciparum (Pf) caused by its dihydrofolate reductase (PfDHFR) mutations, especially the quadruple N51I/C59R/S108N/I164L mutations. The resistance was due to the steric conflict of PYR with S108N. WR99210 (WR), a dihydrotriazine antifolate with a flexible side chain that can avoid such conflict, can overcome this resistance through tight binding with the mutant. To understand factors contributing to different binding affinities of PYR/WR to the wild type (WT) and quadruple mutant (QM), we performed simulations on WR‐WT, WR‐QM, PYR‐WT, and PYR‐QM complexes and found that Ile14 and Asp54 were crucial for PYR/WR binding to PfDHFR due to strong hydrogen bonds. The quadruple mutations cause PYR to form, on average, fewer hydrogen bonds with Ile14 and Leu164, and to be displaced from its optimal orientation for Asp54 interaction. The predicted binding affinity ranking (WR‐QM ≈ WR‐WT ≈ PYR‐WT >> PYR‐QM) reasonably agrees with the inhibition constant (Ki) ranking. Our results reveal important residues for tight binding of PYR/WR to WT/QM, which may be used to evaluate the inhibition effectiveness of antimalarials and to provide fundamental information for designing new drugs effective against drug‐resistant P. falciparum.
Treatment with lenalidomide induces immunoactivating and counter-regulatory immunosuppressive changes in myeloma patients
Authors: Busch A , Zeh D , Janzen V , Mügge L-O , Wolf D , Fingerhut L , Hahn-Ast C , Maurer O , Brossart P , von Lilienfeld-Toal M 
Published: April 2014

Summary
Lenalidomide activates the immune system, but the exact immunomodulatory mechanisms of lenalidomide in vivo are poorly defined. In an observational study we assessed the impact of lenalidomide on different populations of immune cells in multiple myeloma patients. Lenalidomide therapy was associated with increased amounts of a CD8+T cell subset, phenotypically staged between classical central memory T cells (TCM) and effector memory T cells (TEM), consequently termed TCM/TEM. The moderate expression of perforin/granzyme and phenotypical profile of these cells identifies them as not yet terminally differentiated, which makes them promising candidates for the anti-tumour response. In addition, lenalidomide-treated patients showed higher abundance of CD14+ myeloid cells co-expressing CD15. This population was able to inhibit both CD4+ and CD8+T cell proliferation in vitro and could thus be defined as a so far undescribed novel myeloid-derived suppressor cell (MDSC) subtype. We observed a striking correlation between levels of TCM/TEM, mature regulatory T cells (Tregs) and CD14+CD15+MDSCs. In summary, lenalidomide induces both activating and inhibitory components of the immune system, indicating the existence of potential counter-regulatory mechanisms. These findings provide new insights into the immunomodulatory action of lenalidomide.
Transdermal testosterone improves verbal learning and memory in postmenopausal women not on oestrogen therapy
Authors: Davis Susan R. , Jane Fiona , Robinson Penelope J. , Davison Sonia L. , Worsley Roisin , Maruff Paul , Bell Robin J. 
Published: April 2014

SummaryObjectiveThe aim of this study was to examine the effects of testosterone on verbal learning and memory in postmenopausal women.DesignRandomized, placebo‐controlled trial in which participants were randomized (1:1) to transdermal testosterone gel 300 mcg/day, or identical placebo, for 26 weeks.PatientsNinety‐two postmenopausal women aged 55–65 years, on no systemic sex hormone therapy.MeasurementsThe primary outcome was the score for the International Shopping List Task (ISLT) of CogState. Secondary outcomes included other CogState domains, the Psychological General Well‐Being Index (PGWB) and safety variables.ResultsEighty‐nine women, median age 60 years, were included in the primary analysis. Testosterone treatment resulted in statistically significantly better performance for the ISLT (improved verbal learning and memory) compared with placebo, adjusted for age and baseline score (mean difference 1·57; 95%CI 0·13, 3·01) P = 0·03). There were no significant differences for other CogState domains or the PGWB scores. At 26 weeks, the median total testosterone was 1·7 nm (interquartile range (IQR) 1·1, 2·4) in the testosterone group and 0·4 nm (IQR 0·3, 0·5) in the placebo group.ConclusionsThe small but statistically significant effect of testosterone treatment on verbal learning and memory in postmenopausal women provides the basis for further clinical trials.