bluuebunny/crossref_metadata_2025_split huggingface dataset:
The clinical impact of vancomycin‐resistant Enterococcus colonization and bloodstream infection in patients undergoing autologous transplantation
Authors: Ford C.D. , Lopansri B.K. , Gazdik M.A. , Snow G.L. , Webb B.J. , Konopa K.L. , Petersen F.B. 
Published: August 2015

AbstractBackgroundAlthough several studies have documented adverse outcomes for vancomycin‐resistant Enterococcus (VRE) colonization and infection in allogeneic hematopoietic stem cell transplantation (allo‐HSCT) recipients, data are inadequate for patients undergoing autologous (auto‐)HSCT.MethodsWe conducted a retrospective cohort study of 300 consecutive patients receiving an auto‐HSCT between 2006 and 2014. Patients had stool cultures for VRE on admission and weekly during hospitalization.ResultsThirty‐six percent of patients had VRE gastrointestinal (GI) colonization and 3% developed a VRE bloodstream infection (BSI), all of whom were colonized. VRE strain typing of BSI isolates showed that some patients shared identical patterns. Rates of colonization and BSI in colonized patients were similar to simultaneous patients undergoing allo‐HSCT, except that the latter had a higher rate of colonization at admission. A diagnosis of lymphoma was associated with an increased risk of colonization. VRE BSI was associated with longer lengths of stay and possibly higher costs, but no decrease in overall survival, and colonized patients had no VRE infections during the year following discharge. Repeat stool cultures in patients subsequently undergoing allo‐HSCT suggested that most, if not all, VRE‐positive auto‐HSCT patients lose their detectable GI colonization within a few months of discharge.ConclusionVRE colonization is frequent but carries a low risk for infection in patients undergoing auto‐HSCT. However, these patients can serve as reservoirs for transmission to higher risk patients. Moreover, patients may remain colonized if proceeding to an allo‐HSCT shortly after auto‐HSCT, potentially increasing the risk of the allogeneic procedure.
Taxonomic review of Kuzicus Gorochov, 1993 (Tettigoniidae: Meconematinae), with two new species from Thailand and key to species
Authors: TAN MING KAI , DAWWRUENG PATTARAWICH , ARTCHAWAKOM TAKSIN 
Published: August 2015

The taxonomy of genus Kuzicus Gorochov, 1993 (Tettigoniidae: Meconematinae) is reviewed. Two new species are described from Thailand: Kuzicus pakthongchai sp. n. Tan et al. and Kuzicus multidenticulatus sp. n. Tan et al. Kuzicus denticuloides (Kevan, 1993) comb. nov. is transferred from genus Xiphidiopsis. Parakuzicus is removed as a subgenus and considered a distinct genus. A key to species of Kuzicus is provided.
Seleucid Babylonian “Official” and “Private” Seals Reconsidered: A Seleucid Archival Tablet in the Collection of the Mackenzie Art Gallery, Regina
Authors: Wallenfels Ronald 
Published: August 2015

AbstractIt has been convenient for scholars categorizing Hellenistic Babylonian seal impressions found on clay tablets and on clay parchment-sealings to distinguish “private” seals, those owned and used by private individuals acting on their own behalf in personal matters, from “official” seals, those used by office bureaucrats and high-ranking officers of the state or temple in the execution of their respective institution’s affairs. It has been argued on the basis of the tablets’ written contents, with but a single exception that proves the rule, that the tablet seal impressions, known to the field since the mid-nineteenth century, are those of private individuals, specifically the local urban elite, pursuing their personal interests. With the later publication of the clay parchment-sealings, two new seal types were distinguished by their Greek inscriptions and iconography and labeled official: (1) the largely aniconic seals identifying one of several different local Seleucid tax offices; (2) the large oval or rectangular seals with well-modeled intaglios depicting heads/busts and anthropomorphic figures of Greek style all identifying thechreophýlax, the local royal records officer. In the first comprehensive study of the parchment-sealings, Rostovtzeff (1932), expanded the definition of Seleucid official seals to include other large non-epigraphic impressions also displaying portraiture and figures obviously similar to the epigraphic seals, as well as those displaying the Seleucid anchor, certain that these too were all seals of thechreophýlakes. It is argued herein, in part on the basis of the appearance of two such large anepigraphic portrait seals on the edge of a previously unedited Seleucid cuneiform archival tablet, that such seals are not those of royal officers but rather those of preeminent members of urban elite families and their agents; it is also argued that the anchor seal impressions are those of the kings themselves.
A Sketch of (an Actually Serious) Meinongian Presentism
Authors: Paolini Paoletti Michele 
Published: August 2015

AbstractIn this paper I shall “draw” a sketch of a version of Meinongian Presentism. After having briefly presented some data that presentists need to explain and three problems that typically affect presentism (the triviality objection, the problem of the reference of true propositions’ constituents that seem to involve merely past and merely future objects, the truthmaking problem), I shall clarify the bases of my theory. First, I shall reject the actualist presentist assumption, according to which there are no things that do not exist now. Secondly, I shall introduce some notions (e.g., the ones of tensed properties and of temporal existence) that will be useful in order to clarify the contrast between eternalist and non-eternalist metaphysical theories of time. Thirdly, I shall define Meinongian Presentism. Finally, I shall try to demonstrate that this version can deal with the aforementioned problems and with the presentist data in a serious and perspicuous way.
Correlation between nonbridging oxygens and the thermal and optical properties of the TeO2–Li2O–MoO3 glassy system
Authors: Gomes João Luis , Piazzetta Rubyan Lucas Santos , Gonçalves Anderson , Somer Aloisi , da Cruz Gerson Kniphoff , Serbena Francisco Carlos , Novatski Andressa 
Published: August 2015

Abstract
Lithium Dendrite Inhibition on Post-Charge Anode Surface: The Kinetics Role
Authors: Aryanfar Asghar , Cheng Tao , Merinov Boris V. , Goddard William A. , Colussi Agustin J , Hoffmann Michael R. 
Published: August 2015

ABSTRACTWe report experiments and molecular dynamics calculations on the kinetics of electrodeposited lithium dendrites relaxation as a function of temperature and time. We found that the experimental average length of dendrite population decays via stretched exponential functions of time toward limiting values that depend inversely on temperature. The experimental activation energy derived from initial rates as Ea∼ 6-7 kcal/mole, which is closely matched by MD calculations, based on the ReaxFF force field for metallic lithium. Simulations reveal that relaxation proceeds in several steps via increasingly larger activation barriers. Incomplete relaxation at lower temperatures is therefore interpreted a manifestation of cooperative atomic motions into discrete topologies that frustrate monotonic progress by ‘caging’.
Is atmospheric phosphorus pollution altering global alpine Lake stoichiometry?
Authors: Brahney Janice , Mahowald Natalie , Ward Daniel S. , Ballantyne Ashley P. , Neff Jason C. 
Published: August 2015

AbstractAnthropogenic activities have significantly altered atmospheric chemistry and changed the global mobility of key macronutrients. Here we show that contemporary global patterns in nitrogen (N) and phosphorus (P) emissions drive large hemispheric variation in precipitation chemistry. These global patterns of nutrient emission and deposition (N:P) are in turn closely reflected in the water chemistry of naturally oligotrophic lakes (r2 = 0.81, p < 0.0001). Observed increases in anthropogenic N deposition play a role in nutrient concentrations (r2 = 0.20, p < 0.05); however, atmospheric deposition of P appears to be major contributor to this pattern (r2 = 0.65, p < 0.0001). Atmospheric simulations indicate a global increase in P deposition by 1.4 times the preindustrial rate largely due to increased dust and biomass burning emissions. Although changes in the mass flux of global P deposition are smaller than for N, the impacts on primary productivity may be greater because, on average, one unit of increased P deposition has 16 times the influence of one unit of N deposition. These stoichiometric considerations, combined with the evidence presented here, suggest that increases in P deposition may be a major driver of alpine Lake trophic status, particularly in the Southern Hemisphere. These results underscore the need for the broader scientific community to consider the impact of atmospheric phosphorus deposition on the water quality of naturally oligotrophic lakes.
Heterogeneous and asymmetric crustal accretion: New constraints from multibeam bathymetry and potential field data from the Rainbow area of the Mid‐Atlantic Ridge (36°15'N)
Authors: Paulatto Michele , Canales Juan Pablo , Dunn Robert A. , Sohn Robert A. 
Published: August 2015

AbstractAt slow‐spreading mid‐ocean ridges, crustal accretion style can vary significantly along and across ridge segments. In magma‐poor regions, seafloor spreading can be accommodated largely by tectonic processes, however, the internal structure and formation mechanism of such highly tectonized crust are not fully understood. We analyze multibeam bathymetry and potential field data from the Rainbow area of the Mid‐Atlantic Ridge (35°40'N–36°40'N), a section of the ridge that shows diverse accretion styles. We identify volcanic, tectonized and sedimented terrain and measure exposed fault area to estimate the tectonic strain, T, and the fraction of magmatic accretion, M. Estimated T values range from 0.2–0.4 on ridge segments to 0.6‐0.8 at the Rainbow nontransform discontinuity (NTD). At segment ends T is asymmetric, reflecting asymmetries in accretion rate, topography and faulting between inside and outside offset corners. Detachment faults have formed preferentially at inside corners, where tectonic strain is higher. We identify at least two oceanic core complexes on the fossil trace of the NTD, in addition to the Rainbow massif, which occupies the offset today. A gravity high and low magnetization suggest that the Rainbow massif, which hosts a high‐temperature hydrothermal system, was uplifted by a west dipping detachment fault. Asymmetric plate ages indicate localization of tectonic strain at the inside corners and migration of the detachment toward and across the ridge axis, which may have caused emplacement of magma into the footwall. Hydrothermal circulation and heat extraction is possibly favored by increased permeability generated by fracturing of the footwall and deep‐penetrating second‐generation faults.
Tsunami waveform inversion for sea surface displacement following the 2011 Tohoku earthquake: Importance of dispersion and source kinematics
Authors: Hossen M. Jakir , Cummins Phil R. , Dettmer Jan , Baba Toshitaka 
Published: August 2015

AbstractThis paper considers the importance of model parameterization, including dispersion, source kinematics, and source discretization, in tsunami source inversion. We implement single and multiple time window methods for dispersive and nondispersive wave propagation to estimate source models for the tsunami generated by the 2011 Tohoku‐Oki earthquake. Our source model is described by sea surface displacement instead of fault slip, since sea surface displacement accounts for various tsunami generation mechanisms in addition to fault slip. The results show that tsunami source models can strongly depend on such model choices, particularly when high‐quality, open‐ocean tsunami waveform data are available. We carry out several synthetic inversion tests to validate the method and assess the impact of parameterization including dispersion and variable rupture velocity in data predictions on the inversion results. Although each of these effects has been considered separately in previous studies, we show that it is important to consider them together in order to obtain more meaningful inversion results. Our results suggest that the discretization of the source, the use of dispersive waves, and accounting for source kinematics are all important factors in tsunami source inversion of large events such as the Tohoku‐Oki earthquake, particularly when an extensive set of high‐quality tsunami waveform recordings are available. For the Tohoku event, a dispersive model with variable rupture velocity results in a profound improvement in waveform fits that justify the higher source complexity and provide a more realistic source model.
Reaction Phenotyping
Authors: Chen Yuan , Mao Jialin , Fretland Adrian J. 
Published: August 2015

Abstract

Reaction phenotyping is a process to identify enzymes responsible for the metabolism of a drug. It allows for the understanding of the role of metabolizing enzymes in drug elimination through quantifying the contribution of major enzymes to the total clearance of a drug. This is an important step in the prediction of pharmacokinetic and drug–drug interactions (DDI) of a new chemical entity (NCE). This chapter discusses the commonly used
in vitro
cytochrome P450 (P450) reaction phenotyping assays with highlights on key experimental conditions, main deliverables, and differentiation of each approach. The importance in the translation of
in vitro
reaction phenotyping data to
in vivo
is emphasized and highlighted through several published examples. Strategies in the application of CYP reaction phenotyping studies to support clinical pharmacokinetic and DDI assessment at different stages of drug discovery and development are also discussed and recommended.
Laser‐induced surface structures on gold‐coated polymers: Influence of morphology on surface‐enhanced Raman scattering enhancement
Authors: Rebollar Esther , Hernández Margarita , Sanz Mikel , Pérez Susana , Ezquerra Tiberio A. , Castillejo Marta 
Published: August 2015

ABSTRACTThe fabrication of highly sensitive and reproducible substrates for Surface‐Enhanced Raman Scattering (SERS) remains a challenging scientific and technological issue. In this work, laser‐induced periodic surface structures are generated on poly(trimethylen terephthalate) films upon laser irradiation with the linearly polarized beams of a Nd:YAG laser (4th harmonic, 266 nm), an ArF excimer laser (193 nm), and a Titanium:sapphire laser (795 nm), resulting in periods close to the laser wavelength when irradiating at normal incidence, and larger periods for different angles of incidence. Additional irradiation with a circularly polarized beam at 266 nm produces superficial circular structures. The nanostructured polymers are coated with a nanoparticle assembled gold layer by pulsed laser deposition at 213 nm. The capabilities of these substrates for SERS are evaluated using benzenethiol as a test molecule and different degrees of Raman signal enhancement are observed depending on the nanostructure type. The highest enhancement factor is obtained by for nanostructured substrates with the highest values of period, depth, and roughness. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42770.
Comparison of percutaneous device closure versus surgical closure of peri‐membranous ventricular septal defects: A systematic review and meta‐analysis
Authors: Saurav Alok , Kaushik Manu , Mahesh Alla Venkata , White Michael D. , Satpathy Ruby , Lanspa Thomas , Mooss Aryan N. , DelCore Michael G. 
Published: August 2015

BackgroundWhile percutaneous device closure (PDC) is a first‐line therapy for isolated muscular ventricular septal defects (mVSD), surgery is still the preferred approach for peri‐membranous ventricular septal defects (pmVSD).ObjectiveWe sought to compare the outcomes of percutaneous versus open surgical closure of pmVSDs.MethodsPubMed, Cochrane Library, and Web of Science databases were searched through October 15, 2014 for English language studies comparing outcomes of PDC with surgical closure of pmVSDs. Study quality, publication bias, and heterogeneity were assessed. A meta‐analysis of selected studies was performed using a random effects model. Comparison was done for early (<1 month) safety and efficacy outcomes.ResultsSeven studies with a total of 3,134 patients (PDC = 1,312, surgery = 1,822) were identified. Patients in the PDC group were older than those treated surgically (mean age 12.2 vs. 5.5 years, respectively). In six out of seven studies, the mean VSD size was found to be comparable between the treatment arms (PDC 4.9 mm vs. surgery 6.0 mm). Males represented 52% of patients in either group. Follow‐up ranged from 5 to 42 months. No significant differences were observed between PDC vs. surgery in terms of procedural success rate [relative risk (RR): 1.00, confidence interval (CI): 0.99–1.00; P = 0.67]. Combined safety end points for major complications (early death/reoperation/permanent pacemaker) were similar in both groups (RR: 0.55, CI: 0.23–1.35; P = 0.19) as were as other outcomes like post‐procedure significant residual shunt (RR: 0.69, CI: 0.29–1.68; P = 0.41), significant valvular (aortic/tricuspid) regurgitation (RR: 0.70, CI: 0.26–1.86; P = 0.47), and advanced heart block (RR: 0.99, CI: 0.46–2.14; P = 0.98). The need for blood transfusion (RR: 0.02, CI: 0.00–0.05; P < 0.001) and duration of hospital stay [standard mean difference (SMD) −2.17 days, CI: −3.12 to −1.23; P < 0.001] were significantly reduced in the PDC group.ConclusionPercutaneous closure of pmVSD when performed in a selected subgroup of patients is associated with similar procedural success rate without increased risk of significant valvular regurgitation or heart block when compared with surgical closure. © 2015 Wiley Periodicals, Inc.
Identification of Cellular MicroRNA Coupling Strand Displacement Polymerization and Nicking‐Endonuclease‐Based Cleavage
Authors: Miao Peng , Tang Yuguo , Zhang Qi , Bo Bing , Wang Jue 
Published: August 2015

AbstractA target induced recycling amplification method for the detection of cellular microRNA is reported based on strand displacement polymerization and nicking endonuclease mediated cleavage. Moreover, by utilizing silver nanoparticle‐based solid‐state Ag/AgCl reaction, ultrahigh sensitivity is achieved with powerful discriminating towards the identification of target microRNA. The limit of detection is as low as 70 am. This method also allows the detection of cellular microRNA by lysing cells, thus making it a powerful tool for microRNA expression profiling and disease diagnosis.
A cystine‐knot miniprotein from tomato fruit inhibits endothelial cell migration and angiogenesis by affecting vascular endothelial growth factor receptor (VEGFR) activation and nitric oxide production
Authors: Treggiari Davide , Zoccatelli Gianni , Molesini Barbara , Degan Maurizio , Rotino Giuseppe Leonardo , Sala Tea , Cavallini Chiara , MacRae Calum A. , Minuz Pietro , Pandolfini Tiziana 
Published: August 2015

ScopeCystine‐knot miniproteins are bioactive molecules with a broad range of potential therapeutic applications. Recently, it was demonstrated that two tomato cystine‐knot miniproteins (TCMPs) exhibit in vitro antiangiogenic activity on human umbilical vein cells. The aim of the present study was to investigate the effects of a fruit‐specific cystine‐knot miniprotein of tomato on in vitro endothelial cell migration and in vivo angiogenesis using a zebrafish model.Methods and resultsThe cystine‐knot protein purified from tomato fruits using gel filtration LC and RP‐HPLC inhibited cell migration when tested at 200 nM using the wound healing assay, and reduced nitric oxide formation probed by 4‐amino‐5‐methylamino‐27‐difluorofluoscescin diacetate. RT‐PCR and Western blot analyses demonstrated that vascular endothelium growth factor A dependent signaling was the target of TCMP bioactivity. Angiogenesis was inhibited in vivo in zebrafish embryos treated with 500 nM TCMP.ConclusionOur results demonstrate that cystine‐knot miniproteins present in mature tomato fruits are endowed with antiangiogenic activity in vitro and in vivo. These molecules may confer beneficial effects to tomato dietary intake, along with lycopene and other antioxidants. Further investigation is warranted to explore the potential of these compounds as model scaffolds for the development of new drugs.
Gibbs ringing in diffusion MRI
Authors: Veraart Jelle , Fieremans Els , Jelescu Ileana O. , Knoll Florian , Novikov Dmitry S. 
Published: August 2015

PurposeTo study and reduce the effect of Gibbs ringing artifact on computed diffusion parameters.MethodsWe reduce the ringing by extrapolating the k‐space of each diffusion weighted image beyond the measured part by selecting an adequate regularization term. We evaluate several regularization terms and tune the regularization parameter to find the best compromise between anatomical accuracy of the reconstructed image and suppression of the Gibbs artifact.ResultsWe demonstrate empirically and analytically that the Gibbs artifact, which is typically observed near sharp edges in magnetic resonance images, has a significant impact on the quantification of diffusion model parameters, even for infinitesimal diffusion weighting. We find the second order total generalized variation to be a good choice for the penalty term to regularize the extrapolation of the k‐space, as it provides a parsimonious representation of images, a practically full suppression of Gibbs ringing, and the absence of staircasing artifacts typical for total variation methods.ConclusionsRegularized extrapolation of the k‐space data significantly reduces truncation artifacts without compromising spatial resolution in comparison to the default option of window filtering. In particular, accuracy of estimating diffusion tensor imaging and diffusion kurtosis imaging parameters improves so much that unconstrained fits become possible. Magn Reson Med 76:301–314, 2016. © 2015 Wiley Periodicals, Inc.
18O proteomics reveal increased human apolipoprotein CIII in Hispanic HIV‐1+ women with HAART that use cocaine
Authors: Zenón Frances , Jorge Inmaculada , Cruz Ailed , Suárez Erick , Segarra Annabell C. , Vázquez Jesús , Meléndez Loyda M. , Serrano Horacio 
Published: August 2015

PurposeDrug abuse is a major risk factor in the development and progression of HIV‐1. This study defines the alterations in the plasma proteome of HIV‐1‐infected women that use cocaine.Experimental designPlasma samples from 12 HIV‐seropositive Hispanic women under antiretroviral therapy were selected for this study. Six sample pairs were matched between nondrug users and cocaine users. After IgG and albumin depletion, SDS‐PAGE, and in‐gel digestion, peptides from nondrug users and cocaine users were labeled with 16O and 18O, respectively, and subjected to LC‐MS/MS and quantitation using Proteome Discover and QuiXoT softwares and validated by ELISA.ResultsA total of 1015 proteins were identified at 1% false discovery rates (FDR). Statistical analyses revealed 13 proteins with significant changes between the two groups, cocaine and noncocaine users (p < 0.05). The great majority pertained to protection defense function and the rest pertained to transport, homeostatic, regulation, and binding of ligands. Apolipoprotein CIII was increased in plasma of HIV+ Hispanic women positive for cocaine compared to HIV+ nondrug users (p ≤ 0.05).Conclusions and clinical relevanceIncreased human apolipoprotein CIII warrants that these patients be carefully monitored to avoid the increased risk of cardiovascular events associated with HIV, HAART, and cocaine use.