bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel variant of neuronal intranuclear rodlet immunoreactive for 40 kDa huntingtin associated protein and ubiquitin in the mouse brain
Authors: Milman Pavel , Woulfe John 
Published: June 2013

ABSTRACTIntranuclear rodlets (INRs), also known as rodlets of Roncoroni, are poorly understood intranuclear bodies originally identified within neuronal nuclei on the basis of their unique morphology. The mechanisms of their formation, their biochemical composition and their physiological significance remain unknown. Using double immunofluorescence staining of mouse brain sections, we identified a novel variant of INR that is immunoreactive for the 40 kDa huntingtin associated protein (Hap40) and ubiquitin, and provide evidence for the existence of additional INR subtypes sharing ubiquitin immunoreactivity as a common feature. We describe a selective association of these INRs with melanin concentrating hormone (MCH) and tyrosine hydroxylase immunoreactive neurons of the hypothalamus and the locus coeruleus, respectively. We also demonstrate for the first time that biochemically distinct INR subtypes can coexist within a single nucleus where they engage in nonrandom spatial interactions. Our findings highlight the biochemical diversity and cell type‐specific expression of these enigmatic intranuclear structures. J. Comp. Neurol. 521:3832–3846, 2013. © 2013 Wiley Periodicals, Inc.
A speed‐up method of light RDBMS SQLite for stream processing utilizing multicore CPU configurations
Authors: Yamamoto Moriki 
Published: June 2013

SummaryThe data generated at a very high rate by sensors and RFIDs must be handled by continuous queries that respond in real time. Because of its purpose, DSMSs are used in several cases in these large‐scale systems. On the other hand, sensor terminal systems include a light RDBMS generally in many cases. Thus, if a light RDBMS can handle the high‐rate data directly, it is convenient for several applications. This paper proposes a method for speeding up stream processing by using a light RDBMS, SQLite, without any special modifications. If DSMSs are categorized by performance such as large‐, medium‐, and small‐scale, this method aims at one with small‐ or medium‐scale performance. The database performance mainly depends on storage access time, so the proposed method adopts a memory database, a bulk storage records technique, and parallel processing while taking advantage of the multicore CPU configurations of terminal systems. © 2013 Wiley Periodicals, Inc. Electron Comm Jpn, 96(7): 19–31, 2013; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/ecj.11424
Norwegian seiches from the giant 2011 Tohoku earthquake
Authors: Bondevik Stein , Gjevik Bjørn , Sørensen Mathilde B. 
Published: June 2013

AbstractSeismic waves of the giant 2011 Tohoku earthquake triggered seiches in western Norwegian fjords. The seiching began a half hour after the earthquake origin time. The oscillations were noted by eyewitnesses and recorded by surveillance and cell phone cameras. The observations show maximum trough‐to‐peak amplitudes of 1.0–1.5 m and periods of 67–100 s. The water waves were not triggered from the arrival of the surface waves, the timing inferred for other seiches. Instead, the seiching began during the passage of horizontal S waves. We reproduced the S wave trigger by means of a shallow‐water wave model calibrated previously to Norwegian tides and storm surges. The simulations, which used the observed earthquake motion as forcing, show water waves with periods and amplitudes similar to those in the film clips. However, the strongest horizontal ground oscillations with shorter periods (20–30 s) did not contribute much to the formation of the seiches.
Salivary duct carcinoma responding to trastuzumab‐based therapy: Case report and review of the literature
Authors: Krishnamurthy Jairam , Krishnamurty Devi Mukkai , Baker John J. , Zhen Weining , Lydiatt Daniel , Ganti Apar Kishor 
Published: June 2013

BackgroundSalivary duct carcinoma (SDC) is a rare malignancy with a poor prognosis. Human epidermal growth factor receptor‐2 (Her‐2/neu) is overexpressed in SDC and, hence, HER‐2/neu targeted therapy could be an option.MethodsA 72‐year‐old man presented with parotid swelling and cervical lymphadenopathy. He underwent a parotidectomy, modified radical neck dissection, and postoperative chemoradiation with cisplatin. A year later, he developed metastatic disease in the contralateral neck that was treated surgically with right axillary lymphadenopathy. He received radiation to both sites, concurrent with carboplatin. Two years later, he underwent resection of a lung metastasis. He then had progression in the axillary and mediastinal lymph nodes and received 5 cycles of docetaxel and trastuzumab followed by maintenance trastuzumab.ResultsThe patient had a partial response and restaging studies 9 months after therapy discontinuation did not show progression.ConclusionTrastuzumab‐based therapy is a potential therapeutic option for patients with SDC. © 2013 Wiley Periodicals, Inc. Head Neck 35: E372–E375, 2013
Representations of recent and remote autobiographical memories in hippocampal subfields
Authors: Bonnici Heidi M. , Chadwick Martin J. , Maguire Eleanor A. 
Published: June 2013

ABSTRACTThe hippocampus has long been implicated in supporting autobiographical memories, but little is known about how they are instantiated in hippocampal subfields. Using high‐resolution functional magnetic resonance imaging (fMRI) combined with multivoxel pattern analysis we found that it was possible to detect representations of specific autobiographical memories in individual hippocampal subfields. Moreover, while subfields in the anterior hippocampus contained information about both recent (2 weeks old) and remote (10 years old) autobiographical memories, posterior CA3 and DG only contained information about the remote memories. Thus, the hippocampal subfields are differentially involved in the representation of recent and remote autobiographical memories during vivid recall. © 2013 The Authors. Hippocampus Published by Wiley Periodicals, Inc.
Experimental study on the behavior of primary human osteoblasts on laser‐cused pure titanium surfaces
Authors: Markwardt Jutta , Friedrichs Jens , Werner Carsten , Davids Andreas , Weise Hartmut , Lesche Raoul , Weber Anke , Range Ursula , Meißner Heike , Lauer Günther , Reitemeier Bernd 
Published: June 2013

AbstractMandibular tumor resection can lead to a mandibular segmental defect. LaserCUSING® is used to produce a mandibular implant, designed to be identical to the shape of the mandibular defect. Novel microrough surfaces result from this generative technology. In the current study, the behavior of human osteoblasts on untreated laser‐cused titanium specimens or on specimens conditioned with different blasting agents was analyzed. The conditioning of these specimens resulted in surfaces with graded roughness. White light confocal microscopy and single‐cell force spectroscopy were used to characterize the surface of the specimens and to quantify the initial adhesion of primary human osteoblasts to the specimens, respectively. Furthermore, cell growth, viability, apoptosis as well as mineralization of the specimens were analyzed over a time‐period of 2 months. Compared to specimens that were treated with blasting agents, untreated specimens had the highest surface roughness. Quantitative SCFS measurements demonstrated that the adhesion of human primary osteoblasts was the highest on these specimens. Additionally, the untreated specimens allowed the highest number of osteoblasts to colonize. Mineralization studies showed increasing calcium and phosphor elemental composition for all specimen series. It can be concluded that untreated laser‐cused titanium specimens are superior to promote the initial adhesion and subsequent colonization by osteoblast cells. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1422–1430, 2014.
Therapeutic red cell exchange for severe carbon monoxide poisoning
Authors: Zengin Suat , Yılmaz Mehmet , Al Behcet , Yildirim Cuma , Yavuz Erdal , Akcali Aycan 
Published: June 2013

Background and ObjectiveCarbon monoxide (CO) is the most common cause of fatal poisoning worldwide. Therapeutic red cell exchange (TREX) has been used in the treatment of many different diseases. Therefore, we aimed to evaluate the efficacy of TREX on the clinical status, outcome, and discharge of patients with severe CO poisoning. Methods: Demographic data, clinical status, and outcomes of 12 patients that were treated with TREX for severe CO poisoning after referral to the Emergency and Hematology Departments of Gaziantep University between November 2011 and April 2012 were evaluated. Results: Mean carboxyhemoglobin level decreased from (59.7 ± 12.7)% (38–79%) to (17 ± 9.4)% (8–43%), and mean Glasgow Coma Scale score increased from 4 ± 1.6 (3–8) to 9.4 ± 3.5 (3–14) after TREX therapy. Five patients were admitted to the intensive care unit. Rhabdomyolysis developed in one case. Of the 12 patients, 11 were discharged alive, and one patient died. Conclusion: TREX may be an alternative treatment method for reducing mortality and morbidity in cases of severe CO poisoning. J. Clin. Apheresis 28:337–340, 2013. © 2013 Wiley Periodicals, Inc.
Triscyclometalated Iridium(III) Fluoro‐Substituted Carbene Complexes: Character of Emitting Triplet States and Excited State Dynamics
Authors: Chen Chien‐Yu , Tsai Huei‐Ru , Lu Kun‐Yi , Yao Husan‐Hsiao , Yang Yu‐Han Ou , Cheng Chien‐Hong , Chen I‐Chia 
Published: June 2013

AbstractWe report the spectra of UV‐vis absorption, emission and excitation for fluoro‐substituted triscarbene iridium complexes fac‐tris(1‐(4‐fluorophenyl)‐3‐methylimidazolin‐2‐ylidene‐C,C2′) iridium(III), fac‐Ir(fpmi)3, and fac‐tris(1‐(2,4‐fluorophenyl)‐3‐methyl imidazolin‐2‐ylidene‐C,C2′ ) iridium(III), fac‐Ir(dfpmi)3. The decay of emission and transient absorption curves at 266‐nm excitation in the singlet metal‐to‐ligand charge‐transfer (MLCT) band region are recorded. Using quantum chemical calculations‐density functional theory (DFT) and time‐dependent DFT (TD‐DFT) method B3LYP, we obtained their optimized geometries, electronic structures, energies of vertical transitions and oscillator strengths. Both complexes emit in deep blue/near UV which has the highest emission energy for iridium complexes. These emission bands display vibronic structure and a small rigidochromic shift in the low‐temperature. From the measured lifetime data and the emission quantum yield, we obtain a radiative rate constant kr 2.2‐2.4 × 104 s−1 for the emitting state and assign the emitting state to 3π‐π* for these complexes. In subpicosecond transient absorption, we observed an ultrafast rise implying that crossing rate from 1MLCT to this ligand‐centered T1/T2 3π‐π* state is faster than our temporal resolution (300 fs)−1. Two components appear with time constants 0.7‐1.5 ps and 15‐47 ps and are assigned to vibrational cooling/solvation and geometry relaxation, respectively.
Atmospheric and oceanic climate forcing of the exceptional Greenland ice sheet surface melt in summer 2012
Authors: Hanna Edward , Fettweis Xavier , Mernild Sebastian H. , Cappelen John , Ribergaard Mads H. , Shuman Christopher A. , Steffen Konrad , Wood Len , Mote Thomas L. 
Published: June 2013

ABSTRACTThe NASA announcement of record surface melting of the Greenland ice sheet in July 2012 led us to examine the atmospheric and oceanic climatic anomalies that are likely to have contributed to these exceptional conditions and also to ask the question of how unusual these anomalies were compared to available records. Our analysis allows us to assess the relative contributions of these two key influences to both the extreme melt event and ongoing climate change. In 2012, as in recent warm summers since 2007, a blocking high pressure feature, associated with negative NAO conditions, was present in the mid‐troposphere over Greenland for much of the summer. This circulation pattern advected relatively warm southerly winds over the western flank of the ice sheet, forming a ‘heat dome’ over Greenland that led to the widespread surface melting. Both sea‐surface temperature and sea‐ice cover anomalies seem to have played a minimal role in this record melt, relative to atmospheric circulation. Two representative coastal climatological station averages and several individual stations in south, west and north‐west Greenland set new surface air temperature records for May, June, July and the whole (JJA) summer. The unusually warm summer 2012 conditions extended to the top of the ice sheet at Summit, where our reanalysed (1994–2012) DMI Summit weather station summer (JJA) temperature series set new record high mean and extreme temperatures in 2012; 3‐hourly instantaneous 2‐m temperatures reached an exceptional value of 2.2°C at Summit on 11 July 2012. These conditions translated into the record observed ice‐sheet wide melt during summer 2012. However, 2012 seems not to be climatically representative of future ‘average’ summers projected this century.
Effect of water‐soluble fraction of cherry tomatoes on the adhesion of probiotics and Salmonella to intestinal epithelial cells
Authors: Koh Jong Ho , Kim Narae , Hwang Dahyun , Lim Young‐Hee 
Published: June 2013

AbstractBACKGROUNDTomato is one of the most consumed vegetables in the world and contains many valuable nutritional components. Here we investigate the prebiotic effects of cherry tomatoes for improving gut health.RESULTSWater‐soluble dietary fiber was prepared from fresh and processed (heat treatment at 80 °C for 15 min) cherry tomato samples, each with and without Viscozyme L treatment. In the adhesion assays, all water‐soluble dietary fiber samples improved adhesion of probiotics (Lactobacillus rhamnosus and Bifidobacterium bifidum) to intestinal epithelial cells (Caco‐2 cells). Heat treatment in the preparation of juice from cherry tomatoes showed no significant effect on the adhesion of probiotics to Caco‐2 cells. The oligofructose content of samples affected the intestinal adhesion of probiotic bacteria, with higher oligosaccharide concentrations associated with greater adhesion of probiotics and more inhibition of the adhesion of pathogens to Caco‐2 cells.CONCLUSIONThe present results suggest that cherry tomato can act as a prebiotic, with oligofructose potentially being one of its major prebiotic components. © 2013 Society of Chemical Industry
Physicochemical properties and antimicrobial activity of Roselle (Hibiscus sabdariffa L.)
Authors: Jung EunKyung , Kim YoungJun , Joo Nami 
Published: June 2013

AbstractBACKGROUNDThe therapeutic action of a plant depends on its chemical constituents. In this study, experiments were carried out in order to evaluate the effect of extraction conditions on the antioxidative and antimicrobial activities of Roselle (Hibiscus sabdariffa L.).RESULTSRoselle was found to be rich in malic acid, anthocyanins, ascorbic acid and minerals, especially Ca and Fe, but low in glucose. More than 18 volatile compounds were identified by gas chromatography and gas chromatography–mass spectrometry. This herb, which is rich in phenolic compounds and displays DPPH radical scavenging activity, could be a good source of natural antioxidants. The antimicrobial activity of the Roselle water and ethanol extracts was tested with Bacillus subtilis (ATCC6633), Staphylococcus aureus (ATCC6538) and Escherichia coli (ATCC 8739). The inhibition of the Roselle ethanol extract against B. subtilis and S. aureus was slightly higher than that of water extract but this difference was not significant. However, E. coli was strongly inhibited by the Roselle water extract at concentrations of 25 and 50 mg mL−1 as determined by a paper disc method.CONCLUSIONThe obtained results indicated that antioxidant and antimicrobial activity was related to different methods of extraction and Roselle extracts could be a source of therapeutically useful products. © 2013 Society of Chemical Industry
Magnetic resonance susceptibility weighted phase imaging for the assessment of reperfusion intramyocardial hemorrhage
Authors: Goldfarb James W. , Hasan Usama , Zhao Wenguo , Han Jing 
Published: June 2013

PurposeTo quantitatively investigate myocardial phase in multiple‐gradient‐echo images to determine normal phase angle ranges as a function of echo time and anatomical position and then compare phase values from patients with myocardial infarction with those normal ranges to determine the feasibility of intramyocardial hemorrhage detection.MethodsFifteen normal control and 11 patients with reperfused myocardial infarction participated in this prospective study. A 1.5 T magnetic resonance system was used to perform volumetric CINE, high‐pass filtered (HPF) phase, T2‐weighted, T2*‐weighted and late gadolinium‐enhanced infarct imaging at four times points after myocardial infarction. HPF‐phase analyzed using a 16‐segment model was compared with late gadolinium‐enhanced infarct imaging and T2* measurements.ResultsMyocardial HPF‐phase angle in the normal control group was small (−0.008 ± 0.027 radians). There was a difference between anatomical segments, with less variation in septal segments compared with cyclic variations in non‐septal segments. Abnormal phase was only shown in myocardial segments with transmural late gadolinium‐enhanced and microvascular obstruction consistent with intramyocardial hemorrhage. There were six studies from three patients (seven segments at 3 days, five segments at follow‐up) with HPF‐phase outside of normal range indicative of intramyocardial hemorrhage.ConclusionMyocardial HPF‐phase angle is normally small and varies by anatomical myocardial segment. intramyocardial hemorrhage causes a phase decrease beyond normal variations. Magn Reson Med 71:1210–1220, 2014. © 2013 Wiley Periodicals, Inc.
Methylnaltrexone for Opioid‐Induced Constipation in Pediatric Oncology Patients
Authors: Rodrigues Amelia , Wong Cherie , Mattiussi Andrea , Alexander Sarah , Lau Elaine , Dupuis L. Lee 
Published: June 2013

AbstractBackgroundPediatric oncology patients can experience opioid‐induced constipation, which may not respond to laxative treatment. Methylnaltrexone is an opioid receptor antagonist that can reverse opioid‐induced constipation without affecting analgesia. Published literature on the use of methylnaltrexone in children is very limited. This retrospective review describes the effectiveness and safety of methylnaltrexone for opioid‐induced constipation in pediatric oncology patients.ProcedureA retrospective review of health records was conducted for pediatric oncology in‐patients who were prescribed methylnaltrexone between May 2008 and September 2012 at The Hospital for Sick Children. Demographic, clinical, efficacy, and safety data were collected, including; opioid, laxative, and methylnatrexone dosing and frequency.ResultsFifteen patients (median age: 14 years, range: 4–17 years) received methylnaltrexone; 12 received a single dose while three received multiple doses. At the time of methylnaltrexone administration, patients were receiving a median oral morphine dose equivalent of 5.7 mg/kg/day (range: 1.5–29.2 mg/kg/day) and had not had any bowel movements for several days despite treatment with multiple laxatives. Methylnaltrexone was given at a mean dose of 0.15 ± 0.02 mg/kg/dose (range: 3–12 mg/dose) as a subcutaneous injection. After 14 of 19 doses administered, patients had a bowel movement within 4 hours. Three patients had documented mild gastrointestinal upset following methylnaltrexone administration. None reported a reduction of pain control or opioid withdrawal symptoms.ConclusionThis case series suggests that methylnaltrexone is safe and may be effective when given subcutaneously as a 0.15 mg/kg single dose to pediatric oncology patients with opioid‐induced constipation. Pediatr Blood Cancer 2013;60:1667–1670. © 2013 Wiley Periodicals, Inc.
Phenotypic variability of prenatally presenting Gaucher's disease
Authors: Beaujot Juliette , Joriot Sylvie , Dieux Anne , Vaast Pascal , Franquet‐Ansart Hélène , Valat Anne‐Sylvie , Deruelle Philippe , Holder‐Espinasse Muriel , Devisme Louise 
Published: June 2013

What's already known about this topic?

Recently, a new subgroup of Gaucher's disease type 2 with early manifestations during fetal life has been reported.What does this study add?

This report illustrates the diversity of fetal malformations observed in this entity, also called perinatal lethal Gaucher's disease, and, because of phenotypic variability, the autopsy with histological examination is useful to discuss this diagnosis.
Preparation of a solution‐processable, nanostructured ionic polyacetylene
Authors: Ringstrand Bryan , Seifert Sönke , Firestone Millicent A. 
Published: June 2013

ABSTRACTPolymerization of a self‐assembled 1‐dodecyl‐3‐propargylimidazolium bromide ionic liquid (IL) yields a nanostructured ionic polyacetylene. A 1:1 aqueous mixture of the amphiphilic IL produces an ordered lyotropic mesophase that adopts a hexagonal perforated lamellar structure. Rh (I)‐mediated polymerization of the assembled mixture yields a hexagonal modulated lamellar structured polymer. FTIR spectroscopy reveals that the polymer was self n‐doped. The polymer was fractioned into three components with the majority product, possessing an intermediate molecular weight that is soluble in polar organic solvents. In methanol, the optical band gap of the main fraction was determined to be 2.38 eV and was nonemissive. The solution‐processable polymer was airbrush sprayed onto glass substrates to give a liquid‐crystalline, lamellar structured semiconductive film (7.02 × 10−5 S cm−1). The polymer resisted oxidation (degradation) upon storage in air as monitored by vibrational spectroscopy. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2013, 51, 1215–1227
Modification of polyisoprene‐block‐poly(vinyl trimethylsilane) block copolymers via hydrosilylation and hydrogenation, and their gas transport properties
Authors: Gacal Bahadir N. , Filiz Volkan , Shishatskiy Sergey , Rangou Sofia , Neumann Silvio , Abetz Volker 
Published: June 2013

ABSTRACTPolyisoprene‐block‐poly(vinyl trimethylsilane) (PI‐b‐PVTMS) block copolymers having different isoprene contents are successfully chemically modified and characterized by proton nuclear magnetic resonance spectroscopy (1H‐NMR), Fourier transform infrared spectroscopy, gel permeation chromatography, and thermogravimetric analysis. Gas transport properties of the initial block copolymers and their derivatives modified via hydrosilylation and hydrogenation are measured. The modified block copolymers show higher permeabilities for O2 and H2 than the unmodified block copolymers while maintaining similar O2/N2 and H2/N2 selectivities. Hydrosilylation and hydrogenation of block copolymers with a low isoprene content result in a permeability increase for O2 and H2 of 15 to 40%, respectively. Similarly, for block copolymers with high isoprene contents, increases in permeabilities up to 125% are observed compared to initial PI‐b‐PVTMS. © 2013 Wiley Periodicals, Inc. J Polym Sci Part B: Polym. Phys. 2013, 51, 1252–1261