bluuebunny/crossref_metadata_2025_split huggingface dataset:
Definition of stereotactic body radiotherapy
Authors: Guckenberger M. , Andratschke N. , Alheit H. , Holy R. , Moustakis C. , Nestle U. , Sauer O. 
Published: September 2013

AbstractThis report from the Stereotactic Radiotherapy Working Group of the German Society of Radiation Oncology (Deutschen Gesellschaft für Radioonkologie, DEGRO) provides a definition of stereotactic body radiotherapy (SBRT) that agrees with that of other international societies. SBRT is defined as a method of external beam radiotherapy (EBRT) that accurately delivers a high irradiation dose to an extracranial target in one or few treatment fractions. Detailed recommendations concerning the principles and practice of SBRT for early stage non-small cell lung cancer (NSCLC) are given. These cover the entire treatment process; from patient selection, staging, treatment planning and delivery to follow-up. SBRT was identified as the method of choice when compared to best supportive care (BSC), conventionally fractionated radiotherapy and radiofrequency ablation. Based on current evidence, SBRT appears to be on a par with sublobar resection and is an effective treatment option in operable patients who refuse lobectomy.
Cloning, expression of a feruloyl esterase from Aspergillus usamii E001 and its applicability in generating ferulic acid from wheat bran
Authors: Gong Yan-Yan , Yin Xin , Zhang Hui-Min , Wu Min-Chen , Tang Cun-Duo , Wang Jun-Qing , Pang Qing-Feng 
Published: September 2013

Abstract
A cDNA gene (AufaeA), which encodes a mature polypeptide of the type-A feruloyl esterase from Aspergillus usamii E001 (abbreviated to AuFaeA), was cloned and heterologously expressed in Pichia pastoris GS115. One transformant, labeled as P. pastoris GSFaeA4-8, expressing the highest recombinant AuFaeA (reAuFaeA) activity of 10.76 U/ml was selected by the flask expression test. The expressed reAuFaeA was purified to homogeneity with an apparent molecular weight of 36.0 kDa by SDS-PAGE analysis, and characterized using the model substrate of methyl ferulate (MFA). The purified reAuFaeA was optimally active at pH 5.0 and 45 °C, and highly stable at pH 4.0–6.5 and 45 °C or below. Its activity was not significantly affected by metal ions tested and EDTA. The K m and V max of reAuFaeA towards MFA were 4.64 mM and 115.5 U/mg, respectively. High-performance liquid chromatography analysis showed that only 9.7 % of total alkali-extractable ferulic acid (FA) was released from destarched wheat bran by reAuFaeA alone. The released FA increased to 36.5 % when reAuFaeA was used together with a recombinant Aspergillus usamii GH family 11 xylanase A, indicating a synergistic interaction between them.
The importance of health co-benefits in macroeconomic assessments of UK Greenhouse Gas emission reduction strategies
Authors: Jensen Henning Tarp , Keogh-Brown Marcus R. , Smith Richard D. , Chalabi Zaid , Dangour Alan D. , Davies Mike , Edwards Phil , Garnett Tara , Givoni Moshe , Griffiths Ulla , Hamilton Ian , Jarrett James , Roberts Ian , Wilkinson Paul , Woodcock James , Haines Andy 
Published: September 2013

Abstract
We employ a single-country dynamically-recursive Computable General Equilibrium model to make health-focussed macroeconomic assessments of three contingent UK Greenhouse Gas (GHG) mitigation strategies, designed to achieve 2030 emission targets as suggested by the UK Committee on Climate Change. In contrast to previous assessment studies, our main focus is on health co-benefits additional to those from reduced local air pollution. We employ a conservative cost-effectiveness methodology with a zero net cost threshold. Our urban transport strategy (with cleaner vehicles and increased active travel) brings important health co-benefits and is likely to be strongly cost-effective; our food and agriculture strategy (based on abatement technologies and reduction in livestock production) brings worthwhile health co-benefits, but is unlikely to eliminate net costs unless new technological measures are included; our household energy efficiency strategy is likely to breakeven only over the long term after the investment programme has ceased (beyond our 20 year time horizon). We conclude that UK policy makers will, most likely, have to adopt elements which involve initial net societal costs in order to achieve future emission targets and longer-term benefits from GHG reduction. Cost-effectiveness of GHG strategies is likely to require technological mitigation interventions and/or demand-constraining interventions with important health co-benefits and other efficiency-enhancing policies that promote internalization of externalities. Health co-benefits can play a crucial role in bringing down net costs, but our results also suggest the need for adopting holistic assessment methodologies which give proper consideration to welfare-improving health co-benefits with potentially negative economic repercussions (such as increased longevity).
Impact of geographical region on urinary metabolomic and plasma fatty acid profiles in subjects with the metabolic syndrome across Europe: the LIPGENE study
Authors: Walsh Marianne C. , McLoughlin Gerard A. , Roche Helen M. , Ferguson Jane F. , Drevon Christian A. , Saris Wim H. M. , Lovegrove Julie A. , Risérus Ulf , López-Miranda José , Defoort Catherine , Kieć-Wilk Beata , Brennan Lorraine , Gibney Michael J. 
Published: September 2013

The application of metabolomics in multi-centre studies is increasing. The aim of the present study was to assess the effects of geographical location on the metabolic profiles of individuals with the metabolic syndrome. Blood and urine samples were collected from 219 adults from seven European centres participating in the LIPGENE project (Diet, genomics and the metabolic syndrome: an integrated nutrition, agro-food, social and economic analysis). Nutrient intakes, BMI, waist:hip ratio, blood pressure, and plasma glucose, insulin and blood lipid levels were assessed. Plasma fatty acid levels and urine were assessed using a metabolomic technique. The separation of three European geographical groups (NW, northwest; NE, northeast; SW, southwest) was identified using partial least-squares discriminant analysis models for urine (R2X: 0·33, Q2: 0·39) and plasma fatty acid (R2X: 0·32, Q2: 0·60) data. The NW group was characterised by higher levels of urinary hippurate and N-methylnicotinate. The NE group was characterised by higher levels of urinary creatine and citrate and plasma EPA (20 : 5 n-3). The SW group was characterised by higher levels of urinary trimethylamine oxide and lower levels of plasma EPA. The indicators of metabolic health appeared to be consistent across the groups. The SW group had higher intakes of total fat and MUFA compared with both the NW and NE groups (P≤ 0·001). The NE group had higher intakes of fibre and n-3 and n-6 fatty acids compared with both the NW and SW groups (all P< 0·001). It is likely that differences in dietary intakes contributed to the separation of the three groups. Evaluation of geographical factors including diet should be considered in the interpretation of metabolomic data from multi-centre studies.
The Trickster in Egypt's January 25th Revolution
Authors: Armbrust Walter 
Published: September 2013

AbstractThe term “counter-revolution” evokes a straightforward contestation of political claims in a revolutionary situation. But contestation is not a zero-sum game: this side wins; the other side loses, and power remains the same. A revolutionary situation is unpredictable. New formulations of political claims may emerge in a protracted moment of “liminal crisis”—a kind of political ritual with no master of ceremonies capable of ending it. Indeed, the meaning of the political prize itself might be open to reinterpretation. My paper examines counter-revolution through the lens of Taufiq ‘Ukasha, an Egyptian talk show host and former member of the deposed National Democratic Party. Since the Revolution ‘Ukasha has become increasingly prominent as an unacknowledged spokesman for Egypt's Military Council, which assumed executive powers in the wake of the Mubarak regime's collapse. I argue that ‘Ukasha should not be understood simply as afilul—a remnant of the old regime. He is rather a “trickster,” a creature at home in the betwixt-and-between of open-ended liminality, and as such not an instrument of a socially grounded political power. In an environment in which the usual points of social and political orientation are called into question, the significance of a trickster is that he or she can become an object of emulation, an instrument of “schismogenesis”—the creation of a new social formation. A trickster, as a creature of pure liminality, is particularly prone to generating perverted forms of social knowledge. In ‘Ukasha's case, this new social formation is an unprecedented formulation of Egyptian militarism.
“Is this city yours or mine?” Political Sovereignty and Eurasian Urban Centers in the Ninth through Twelfth Centuries
Authors: Grinberg Lyuba 
Published: September 2013

AbstractNumerous scholars have emphasized the “centrality” of Inner Asia to furthering our understanding of global, or cross-cultural phenomena, and the role of such phenomena in the preservation, modification, and transmission of historical experience. Yet the research has almost exclusively been carried out by specialists in Chinese civilization, and as one moves further away from the Chinese sphere of influence the notion of Eurasia as an integrated socio-political unit of historical analysis becomes more problematic. Here I attempt to bridge the western and eastern edges of the great steppe by focusing on a specific aspect of Inner Asian political culture—the phenomenon of shared sovereignty between military-based ruling dynasties and their urban constituencies—in the principalities of Rus' and the oases of Transoxiana, between the ninth and twelfth centuries. I propose that the dual administrative structure that developed in the two regions was an autochthonic, Eurasian state-formation, distinct from the city-state and imperial models, which emerged as a result of what Joseph Fletcher identified as “horizontal continuities.”
The Colonial Emergence of a Statistical Imaginary
Authors: Rowse Tim , Shellam Tiffany 
Published: September 2013

AbstractIntellectual networks linking humanitarians in Britain, Western Australia, and New Zealand in the 1850s and 1860s operationalized the concept of native “protection” by arguing contra demographic pessimists that native peoples could survive if their adaptation was thoughtfully managed. While the population-measurement capacities of the colonial governments of Western Australia and New Zealand were still weak, missionaries pioneered the gathering of the data that enabled humanitarians to objectify natives as populations. This paper focuses on Francis Dart Fenton (in New Zealand), Florence Nightingale (in Britain), and Rosendo Salvado (in Western Australia) in the 1850s and 1860s. Their belief in the necessity of population statistics manifests the practical convergence of colonial humanitarianism with public health perspectives and with “the statistical movement” that had become influential in Britain in the 1830s. We draw attention to the materialism and environmentalism of these three quantifiers of natives, and to how native peoples were represented as governable through knowledge of their physical needs and vulnerabilities.
Geochronology, geochemistry and petrogenesis of the late Palaeoproterozoic A-type granites from the Dunhuang block, SE Tarim Craton, China: implications for the break-up of the Columbia supercontinent
Authors: YU SHENG-YAO , ZHANG JIAN-XIN , ZHAO XI-LIN , GONG JIANG-HUA , LI YUN-SHUAI 
Published: September 2013

AbstractThe discovery ofc. 1.77 Ga A-type granite in the Tarim Craton (TC) provides the first evidence that supports an extensional event related to fragmentation of the Columbia supercontinent in the late Palaeoproterozoic. We present laser-ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) zircon U–Pb ages, Lu–Hf isotopic data and the whole-rock geochemical and Nd isotopic data of A-type granites in the Dunhuang area in the SE Tarim Craton. Zircon U–Pb dating for three granite samples indicate that they were emplaced atc. 1.77 Ga. Zircons from these granites have εHf(t) values ranging from –5.9 to 8.7, corresponding to two-stage model ages of 1.9–2.7 Ga. These granites exhibit the following petrological geochemical characteristics that are typical of A-type granite: (a) high content of SiO2and alkalis (i.e. high K2O + Na2O with K2O/Na2O > 1), enrichment of high-field-strength elements (HFSE) and rare Earth elements (REE) (except for Eu) and extreme depletion of Ba, Sr, P, Ti and Eu; (b) 10000×Ga/Al ratios in the Dunhuang granites of 3.5–4.4, with an average value of 3.79 which is similar to the global average of 3.75 for A-type granites; (c) the presence of characteristic minerals such as amphibole, sphene and perthite; and (d) zirconium saturation temperature results indicate that the Dunhuang granites have high initial magmatic temperatures in the range 887–950°C, similar to those of typical of A-type granites. Whole-rock εNd(t) values range from –2.5 to –6.2 andTDMmodel ages from 2.3 to 2.7 Ga. Nd–Hf isotopic and whole-rock geochemical data indicate that these granites were most likely derived from the late Archean crustal source in a post-collisional/post-orogenic extensional tectonic environment. The late Palaeoproterozoic A-type granites in the TC could be correlated with those of the North China Craton (NCC), India and the Canadian Shield, thus demonstrating extensional tectonics and break-up of the Columbia supercontinent.
Administration of dicyandiamide to dairy cows via drinking water reduces nitrogen losses from grazed pastures
Authors: WELTEN B. G. , LEDGARD S. F. , LUO J. 
Published: September 2013

SUMMARYOral administration of the nitrification inhibitor dicyandiamide (DCD) to ruminants for excretion in urine represents a targeted mitigation strategy to reduce nitrogen (N) losses from grazed pasture. A farmlet grazing study was undertaken to examine the environmental benefits of administering DCD in trough water to non-lactating Friesian dairy cows that consecutively grazed 12 replicated plots (each 627 m2with a grazing intensity of up to 319 cows/ha/day) during two grazing rotations in the winter of 2007 in the Waikato region, New Zealand. Nitrate-N (NO3−-N) leaching losses were measured using ceramic cup samplers (600 mm soil depth) and gaseous emissions of nitrous oxide (N2O) were quantified using a static chamber technique in the DCD and control treatments. Administration of DCD in trough water had no effect on daily water intake by dairy cows, which averaged 15 and 18 l/cow/day for the June and August grazing rotations, respectively. This resulted in a mean daily DCD intake of 46 and 110 g/cow/day, respectively. The DCD farmlet had significantly lower NO3−-N concentrations in leachate at the last three samplings, which reduced total NO3−-N leaching losses by 40% (from 32·0 to 19·2 kg N/ha). The DCD treatment reduced N2O emission rates compared to the control treatment following the August grazing, resulting in a 45% reduction in total N2O emissions relative to the control treatment (from 0·49 to 0·27 kg N2O-N/ha). This preliminary study highlights the potential for administering ruminants with DCD as an effective mitigation option for reducing N losses from agricultural systems.
Changes of rumen pH, fermentation and microbial population as influenced by different ratios of roughage (rice straw) to concentrate in dairy steers
Authors: WANAPAT M. , GUNUN P. , ANANTASOOK N. , KANG S. 
Published: September 2013

SUMMARYThe current study was designed to determine the effect of roughage to concentrate ratio (R : C) on rumen pH, fermentation and bacterial population in dairy steers. Four rumen fistulated dairy steers (170±20 kg) were randomly assigned according to a 4×4 Latin square design, in which the steers were fed with four dietary treatments with different R : C ratios of 0·8 : 0·2, 0·6 : 0·4, 0·4 : 0·6 and 0·2 : 0·8, respectively. All animals were kept in individual pens and received feed according to the respective R : C ratios at 0·025 body weight (BW)/d; urea-treated rice straw (prepared using 3·5 kg urea+100 kg water sprayed onto 100 kg of rice straw) was used as a roughage source. The experiment was conducted for four periods of 21 days each. During the first 14 days, feed intake was measured and the animals were then moved to metabolism crates for total urine and faecal collection for 7 days. Total dry matter intake (DMI) was similar among treatments. Energy intake increased as the proportion of concentrate in the diet increased. Apparent digestibilities of dry matter (DM), organic matter (OM) and crude protein (CP) were improved, while neutral detergent fibre (NDF) and acid detergent fibre (ADF) were reduced when the levels of concentrate increased. A decreasing ratio of R : C reduced rumen pH linearly, from 6·4 to 5·9 at 0·2 : 0·8. High levels of concentrate impacted on volatile fatty acids (VFA) molar proportions and decreased acetate (C2) linearly, while propionate (C3) was increased, leading to decreased C2 : C3 ratio. Numbers of protozoa, fungi and proteolytic bacteria were not affected by R : C ratio. Cellulolytic bacteria decreased linearly while amylolytic bacteria increased linearly with 0·60 and 0·80 concentrates. Quantitative polymerase chain reaction (qPCR) based on 16S RNA revealed thatFibrobacter succinogenesnumbers were increased when steers were fed with R : C ratio of 0·8 : 0·2. Conjugated linoleic acid (CLA)-producing bacteria, especially those ofButyrivibrio fibrisolvens, increased linearly with R : C ratios of 0·8 : 0·2 and 0·6 : 0·4, whileMegasphaera elsdenii, a lactate-utilizing bacterium and reported producer oftrans-10,cis-12 CLA increased linearly with R : C ratio of 0·8 : 0·2. In addition, microbial CP synthesis increased quadratically when steers were fed high levels of concentrate. However, the efficiency microbial N synthesis (EMNS) based on OM, truly digested in the rumen, was not affected by different R : C ratios. From the current study, it can be concluded that roughage to concentrate ratio of 0·4 : 0·6 had positive effects for the creation of healthy rumen (rumen pH and ecology), and improved energy intake and rumen fermentation, particularly propionic acid and microbial protein synthesis, in dairy steers fed urea-treated rice straw as a roughage source.
Asymmetric oscillatory expansion of a cylindrical plasma
Authors: KARIMOV A.R. , YU M.Y. , STENFLO L. 
Published: September 2013

AbstractAsymmetric oscillatory expansion of a cylindrical plasma layer into vacuum is investigated analytically by solving the fluid equations of the electrons and ions together with the Maxwell's equations. For the problem considered, it is found that the asymmetrical flow components are strongly affected by the symmetrical components, but not the vice versa.
“I Kind of Got Dragged into Global History”: An Interview with Jan de Vries
Authors: Kemper Simon , Pucek Kaspar , Toivanen Mikko 
Published: September 2013

On the morning of 30 May, freshly arrived from Wageningen, Professor Jan de Vries arrives at Leiden University. Later this day, he will be giving a lecture, to a full room, on his take on the so-called Great Divergence debate, but beforehand he has kindly agreed to an interview with Itinerario. Apart from him, present are three graduate students, the authors of this piece, and Professor Jos Gommans of Leiden University, in whose office we are, and whose grandmother's stately chair serves as the interviewee's place of honour. Over fresh cups of coffee, an amiable but wide-ranging conversation unfolds.Professor Jan de Vries, of the University of California, Berkeley, is a respected economic historian with a long career reaching back to the 1970s. His work has taken on such diverse topics as Dutch rural economy in the Golden Age, European urbanisation and, in his widely influential book The Industrious Revolution, the developments that in his view paved the way to industrialisation in Europe. Lately his work has also taken a global turn, as he has addressed topics such as the Great Divergence and globalisation in history.There are so many people named Jan de Vries. Helped by Wikipedia, we first thought we had somehow overlooked your early career as a motor driver! Yes, even in Berkeley there is more than one of us. If you look at the telephone book, you'll find three of us. One was even at the university [University of California, Berkeley]. He was an electrical engineer who worked in the space science laboratory which was affiliated with the university. Many years ago I had a telephone call in my office from a Dutchman who said, “Jan, I am waiting here for you.” And after a little bit he said, “you are Jan de Vries the electronicus [electronic engineer], right?” I answered “no, I am Jan de Vries the historicus [historian].” Later I met my name-sake and we still see each other periodically.
Craft and Small Scale Production in the Global Economy: Gujarat and Kachchh in the Eighteenth and Twenty-first Centuries
Authors: Berg Maxine 
Published: September 2013

India's production of fine luxury and craft goods for world markets was discovered and exploited by Europeans in the seventeenth and eighteenth centuries. Textile producers in Gujarat, the Coromandel Coast, and Bengal applied fine craft skills to European designs, colour codes, and textile lengths and widths. Through the intervention of the East India Companies and private traders as well as their intermediaries, brokers and local merchants, weavers, and printers produced the goods to satisfy Western markets just as they had done for Eastern and African markets in the centuries before.Today Indian craftspeople are engaging in a new phase of production for global markets. They are using traditional techniques of the kind that attracted Western buyers in the seventeenth and eighteenth centuries: hand weaving, hand block printing, and natural dyes. Accessing the niche national and international markets needed to provide a future for these crafts is a major challenge. This article focuses on the artisans, skills and markets in one area of India—the region of Kachchh in northern Gujarat, even now considered a remote part of the new global India. It sets this within a wider context of Gujarat and the earlier and more recent history of its textile industries. Douglas Haynes's recent book, Small Town Capitalism in Western India (2012) provides a framework for the study of small-scale industry, and the article will address his subject and methods. The new sources used are a collection of oral histories of craftspeople in a range of industries. These oral histories address skills and training across generations, and how these crafts have adapted and continue to adapt to the demands of national and world markets.