bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel technique for transcatheter patent ductus arteriosus closure in extremely preterm infants using commercially available technology
Authors: Zahn Evan M. , Nevin Phillip , Simmons Charles , Garg Ruchira 
Published: April 2014

ObjectivesTo describe a new technique for transcatheter patent ductus arteriosus (PDA) closure in extremely preterm infants using commercially available technology.BackgroundPDA in premature neonates continues to be a significant clinical problem contributing importantly to both morbidity and mortality. Surgical ligation and medical therapy both have their drawbacks.Material and MethodsHospital records and catheterization reports of all premature neonates (< 32 weeks gestation) who underwent transcatheter PDA closure between March 2013 and February 2014 were reviewed. Particular attention was paid to procedural details, complications, and short and mid‐term outcomes.ResultsSix premature infants born at gestational ages ranging between 26 and 31 weeks (median, 26 weeks) underwent attempted transcatheter PDA closure using the Amplatzer Vascular Plug II (AVP II). Median age and weight was 21.5 days (16–80 days) and 1,180 g (870–2,240 g), respectively. Fluoroscopy and echocardiography were used to guide device. Contrast angiography was not used in any patient. Complete closure was achieved in all patients with no major procedural complications. Median fluoroscopy and procedural times were 9.4 (0–19.5) and 51.5 (33–87) min, respectively. All patients were alive at the time of this report. There were no instances of device migration, left pulmonary artery (LPA), or aortic coarctation.ConclusionsThis preliminary study demonstrates that transcatheter PDA closure can be successfully performed in extremely preterm neonates using currently available technology with a high success rate and a low incidence of complications. This report also describes a novel transvenous approach using a combination of echocardiography and judicious use of fluoroscopy to avoid arterial access in this fragile patient population. © 2014 Wiley Periodicals, Inc.
Acute small bowel volvulus in a 2‐month‐old infant
Authors: Wouters Roderick , Raber Menno , van Baren Robertine 
Published: April 2014

Key Clinical MessageAbdominal cystic lymphangiomas are rare and occur secondary to congenital malformation of the lymphatics, mostly in the mesenterium. Acute or chronic volvulus of the small bowel may occur by traction of the lymphangioma. Therapy includes resection of the lymphangioma and of the small bowel involved.
Formic Acid Electrooxidation on Noble‐Metal Electrodes: Role and Mechanistic Implications of pH, Surface Structure, and Anion Adsorption
Authors: Brimaud Sylvain , Solla‐Gullón José , Weber Isabella , Feliu Juan M. , Behm R. Jürgen 
Published: April 2014

AbstractThe influence of the electrolyte pH on formic acid (HCOOH) electrooxidation is investigated on both polycrystalline Pt and Au electrodes and on single‐crystalline Au electrodes in perchloric and sulfuric acid‐based electrolytes. On Au electrodes, the potentiodynamic oxidation currents are found to depend, in a nonlinear way, on the electrolyte pH in a bell‐shaped relation, with a maximum of the catalytic activity at the pKa of HCOOH. On polycrystalline Pt electrodes, this feature is not observed; the catalytic activity increases steadily with increasing pH up to a pH value of approximately 5, which is followed by a plateau until pH 10, in contrast with recent observations [J. Joo, T. Uchida, A. Cuesta, M. T. M. Koper, M. Osawa, J. Amer. Chem. Soc.­ 2013, 135, 9991–9994]. In addition, for Au surfaces, the reaction is only weakly influenced by the electrode surface structure, whereas for Pt, structural effects are known to be considerable. Anion effects, in contrast, are much stronger for the reaction on Au electrodes compared to Pt electrodes. Also, it is shown that Pt‐group‐metal‐free Au electrodes do not oxidize molecular hydrogen under reaction conditions. The results are discussed in relation to findings in previous mechanistic studies. Most importantly, the activity on both electrodes is closely correlated with the concentration of HCOO−, and for Au correlates with both HCOO− and HCOOH concentrations. Based on these results, a number of mechanistic proposals put forward in earlier studies must be discarded, and examples for mechanisms compatible with these results are discussed.
Desolvation and Dehydrogenation of Solvated Magnesium Salts of Dodecahydrododecaborate: Relationship between Structure and Thermal Decomposition
Authors: Chen Xuenian , Liu Yi‐Hsin , Alexander Anne‐Marie , Gallucci Judith C. , Hwang Son‐Jong , Lingam Hima Kumar , Huang Zhenguo , Wang Cong , Li Huizhen , Zhao Qianyi , Ozkan Umit S. , Shore Sheldon G. , Zhao Ji‐Cheng 
Published: April 2014

AbstractAttempts to synthesize solvent‐free MgB12H12 by heating various solvated forms (H2O, NH3, and CH3OH) of the salt failed because of the competition between desolvation and dehydrogenation. This competition has been studied by thermogravimetric analysis (TGA) and temperature‐programmed desorption (TPD). Products were characterized by IR, solution‐ and solid‐state NMR spectroscopy, elemental analysis, and single‐crystal or powder X‐ray diffraction analysis. For hydrated salts, thermal decomposition proceeded in three stages, loss of water to form first hexahydrated then trihydrated, and finally loss of water and hydrogen to form polyhydroxylated complexes. For partially ammoniated salts, two stages of thermal decomposition were observed as ammonia and hydrogen were released with weight loss first of 14 % and then 5.5 %. Thermal decomposition of methanolated salts proceeded through a single step with a total weight loss of 32 % with the release of methanol, methane, and hydrogen. All the gaseous products of thermal decomposition were characterized by using mass spectrometry. Residual solid materials were characterized by solid‐state 11B magic‐angle spinning (MAS) NMR spectroscopy and X‐ray powder diffraction analysis by which the molecular structures of hexahydrated and trihydrated complexes were solved. Both hydrogen and dihydrogen bonds were observed in structures of [Mg(H2O)6B12H12]⋅6 H2O and [Mg(CH3OH)6B12H12]⋅6 CH3OH, which were determined by single‐crystal X‐ray diffraction analysis. The structural factors influencing thermal decomposition behavior are identified and discussed. The dependence of dehydrogenation on the formation of dihydrogen bonds may be an important consideration in the design of solid‐state hydrogen storage materials.
Recognition of Free Tryptophan in Water by Synthetic Pseudopeptides: Fluorescence and Thermodynamic Studies
Authors: Martí‐Centelles Vicente , Izquierdo M. Angeles , Burguete M. Isabel , Galindo Francisco , Luis Santiago V. 
Published: April 2014

AbstractPseudopeptidic receptors containing an acridine unit have been prepared and their fluorescence response to a series of amino acids was measured in water. Free amino acids, not protected either at the C or the N terminus, were used for this purpose. The prepared receptors display a selective response to tryptophan (Trp) versus the other assayed amino acids under acidic conditions. The macrocyclic nature of the receptor is important as the fluorescence quenching is higher for the macrocyclic compound than for the related open‐chain receptor. Notably, under the experimental acidic conditions used, both the receptor and guest are fully protonated and positively charged; thus, the experimental results suggest the formation of supramolecular species that contain two positively charged organic molecular components in proximity stabilized through aromatic–aromatic interactions and a complex set of cation‐anion‐cation interactions. The selectivity towards Trp seems to be based on the existence of a strong association between the indole ring of the monocharged amino acid and the acridinium fragment of the triprotonated form of the receptor, which is established to be assisted by the interaction of the cationic moieties with hydrogen sulfate anions.
A “Catch‐and‐Release” Protocol for Alkyne‐Tagged Molecules Based on a Resin‐Bound Cobalt Complex for Peptide Enrichment in Aqueous Media
Authors: Miyazaki Ayako , Asanuma Miwako , Dodo Kosuke , Egami Hiromichi , Sodeoka Mikiko 
Published: April 2014

AbstractThe development of new and mild protocols for the specific enrichment of biomolecules is of significant interest from the perspective of chemical biology. A cobalt–phosphine complex immobilised on a solid‐phase resin has been found to selectively bind to a propargyl carbamate tag, that is, “catch”, under dilute aqueous conditions (pH 7) at 4 °C. Upon acidic treatment of the resulting resin‐bound alkyne–cobalt complex, the Nicholas reaction was induced to “release” the alkyne‐tagged molecule from the resin as a free amine. Model studies revealed that selective enrichment of the alkyne‐tagged molecule could be achieved with high efficiency at 4 °C. The proof‐of‐concept was applied to an alkyne‐tagged amino acid and dipeptide. Studies using an alkyne‐tagged dipeptide proved that this protocol is compatible with various amino acids bearing a range of functionalities in the side‐chain. In addition, selective enrichment and detection of an amine derived from the “catch and release” of an alkyne‐tagged dipeptide in the presence of various peptides has been accomplished under highly dilute conditions, as determined by mass spectrometry.
Modeling of the Stress Behavior of Confined Particle Beds
Authors: Mütze Thomas 
Published: April 2014

AbstractDas Beanspruchungsverhalten von Gutbetten beschreibt den Zusammenhang zwischen der Kraft, die auf ein Gutbett wirkt, und der Energie, die dem Gutbett insgesamt zugeführt wird. Es ist eng mit der Verdichtung des Gutbetts verknüpft, wobei hier eine rein elastische und eine rein plastische Verformung zu unterscheiden ist. Die elastische Verformung kann durch die Elastizität E des Gutbetts als materialspezifische und vom E‐Modul des Feststoffs unabhängige Kenngröße charakterisiert werden. Die Modellierung des Beanspruchungsverhaltens baut auf dem plastischen Verformungsverhalten auf.
Binding to Large Enzyme Pockets: Small‐Molecule Inhibitors of Trypanothione Reductase
Authors: Persch Elke , Bryson Steve , Todoroff Nickolay K. , Eberle Christian , Thelemann Jonas , Dirdjaja Natalie , Kaiser Marcel , Weber Maria , Derbani Hassan , Brun Reto , Schneider Gisbert , Pai Emil F. , Krauth‐Siegel R. Luise , Diederich François 
Published: April 2014

AbstractThe causative agents of the parasitic disease human African trypanosomiasis belong to the family of trypanosomatids. These parasitic protozoa exhibit a unique thiol redox metabolism that is based on the flavoenzyme trypanothione reductase (TR). TR was identified as a potential drug target and features a large active site that allows a multitude of possible ligand orientations, which renders rational structure‐based inhibitor design highly challenging. Herein we describe the synthesis, binding properties, and kinetic analysis of a new series of small‐molecule inhibitors of TR. The conjunction of biological activities, mutation studies, and virtual ligand docking simulations led to the prediction of a binding mode that was confirmed by crystal structure analysis. The crystal structures revealed that the ligands bind to the hydrophobic wall of the so‐called “mepacrine binding site”. The binding conformation and potency of the inhibitors varied for TR from Trypanosoma brucei and T. cruzi.
An integrated spectral imaging system for producing color images of static and moving objects
Authors: Tominaga Shoji , Nishioka Daisuke , Horiuchi Takahiko 
Published: April 2014

AbstractAn integrated spectral imaging system constructed by synchronizing a programmable light source, a high‐speed monochrome camera, and a display device is proposed to produce tristimulus images of static and moving objects effectively in real time onto the display. This system is called the CIE‐XYZ display. Active spectral illuminants, containing both the device characteristics of camera and display, are projected onto object surfaces as time sequence. The images are captured synchronously by the camera and quickly transmitted to the display device in the RGB signal form so that the accurate tristimulus images are displayed. First, we describe the principle of the CIE‐XYZ tristimulus display. The theoretically optimal illuminants contain negative parts in the spectral curves. Second, we design practical illuminants with all positive spectral curves. The color images in our system are composed of the time sequence of RGB component images. Then, the synthesized color images on the display contain color artifacts when objects move fast. An image processing algorithm for correcting the motion color artifact is proposed based on optical flow estimation using a graphics processing unit. The comprehensive performance of the proposed system and algorithms is examined using both static and moving objects. © 2014 Wiley Periodicals, Inc. Col Res Appl, 40, 329–340, 2015
Long‐Lasting Oscillations in the Electro‐Oxidation of Formic Acid on PtSn Intermetallic Surfaces
Authors: Perini Nickson , Batista Bruno C. , Angelo Antonio C. D. , Epstein Irving R. , Varela Hamilton 
Published: April 2014

AbstractEven when in contact with virtually infinite reservoirs, natural and manmade oscillators typically drift in phase space on a time‐scale considerably slower than that of the intrinsic oscillator. A ubiquitous example is the inexorable aging process experienced by all living systems. Typical electrocatalytic reactions under oscillatory conditions oscillate for only a few dozen stable cycles due to slow surface poisoning that ultimately results in destruction of the limit cycle. We report the observation of unprecedented long‐lasting temporal oscillations in the electro‐oxidation of formic acid on an ordered intermetallic PtSn phase. The introduction of Sn substantially increases the catalytic activity and retards the irreversible surface oxidation, which results in the stabilization of more than 2200 oscillatory cycles in about 40 h; a 30–40‐fold stabilization with respect to the behavior of pure Pt surfaces. The dynamics were modeled and numerical simulations point to the surface processes underlying the high stability.
Metal Nanoparticles with Liquid‐Crystalline Ligands: Controlling Nanoparticle Superlattice Structure and Properties
Authors: Lewandowski Wiktor , Wójcik Michał , Górecka Ewa 
Published: April 2014

AbstractNanoparticle ordered aggregates are promising candidates for future application in a variety of sensing, optical and electronic technologies, mainly based on collective interactions between individual nano‐building blocks. Physicochemical properties of such assemblies depend on nanoparticle spacing, therefore a lot of effort throughout the last years was put on development of assembly methods allowing control over aggregates structure. In this minireview we describe efficient self‐assembly process based on the utilization of liquid‐crystalline ligands grafted onto nanoparticle surface. We show strategies used to synthesize liquid‐crystalline nanoparticles as well as discuss parameters influencing structural and thermal characteristic of aggregates. It is also demonstrated that the liquid‐crystalline approach offers access to dynamic self‐assembly and metamaterials with anisotropic plasmonic properties, which makes this strategy unique among others.
Synthesis and Stability of N,N′‐Dialkyl‐1,13‐dimethoxyquinacridinium (DMQA+): A [4]Helicene with Multiple Redox States
Authors: Sørensen Thomas Just , Nielsen Merete F. , Laursen Bo W. 
Published: April 2014

AbstractN,N′‐Dialkyl‐1,13‐dimethoxyquinacridinium (DMQA+) is a configurationally locked [4]helicene, a stable carbenium ion and a potent near‐infrared emitter. The versatile synthesis and resolution into M and P enantiomers has made DMQA+ and its congener helicenium derivatives attractive chiral dyes and building blocks. In the present study, electrochemical and spectroscopic studies showed that several redox states of DMQA+ are accessible and stable. The cation stability towards nucleophiles is determined and it is shown that the addition of OH− proceeds with a surprisingly low rate of reaction. The synthetic methodologies leading to DMQA+ are described, and the chemistry occurring from the different redox states of DMQA is identified. This [4]helicene is shown to be a unique molecular framework that is stable as a neutral radical and very stable as a carbenium ion.
Predicting Psychotherapy Dropouts: A Multilevel Approach
Authors: Kegel Alexander F. , Flückiger Christoph 
Published: April 2014

The role of therapeutic processes in predicting premature termination of psychotherapy has been a particular focus of recent research. The purpose of this study was to contrast outpatients who completed therapy and those who dropped out with respect to their self‐reported in‐session experiences of self‐esteem, mastery, clarification and the therapeutic alliance. The 296 patients with mixed disorders were treated with an integrative form of cognitive–behavioural therapy without pre‐determined time limit (M = 20.2 sessions). Multilevel analyses indicated that patients who did not completetreatment reported, on average, lower levels of self‐esteem, mastery and clarification and lower ratings of their therapeutic alliance in treatment in contrast to patients who completed therapy. Patient‐reported change in self‐esteem experiences over the course of treatment turned out to be the strongest predictor of dropout from psychotherapy or successful completion. When dropout occurred before the average treatment length was reached, patients reported fewer clarifying experiences as early as the first session and their ratings of the therapeutic alliance were characterized by an absence of positive development. Both of these aspects seem to be involved in patients' decisions to leave treatment early. The findings underscore the importance of the therapeutic process in understanding the mechanisms behind treatment dropout. Copyright © 2014 John Wiley & Sons, Ltd.Key Practitioner Message

Analyses data from 296 patients at a private outpatient clinic in a routine practice setting (CBT).
Completer/dropout definition: presence or absence of measurement battery at post-assessment.
Focuses on change in therapy processes by investigating post‐session reports.
Finds that positive changes in self‐esteem experiences is the most robust predictor of dropout, followed by ratings of clarification experiences and the global alliance.
In line with recent dropout research, these process indicators might help to detect therapeutic situations that are connected with psychotherapy dropouts.
Flow‐oriented detection of low‐rate denial of service attacks
Authors: Wu Zhijun , Hu Ran , Yue Meng 
Published: April 2014

SummaryIn this paper, an approach of detecting low‐rate denial of service attack is proposed on the basis of principal component analysis algorithm. The proposed approach analyzes low‐rate denial of service attack flows and handles complicated network flows by using principal component analysis algorithm to establish the network traffic matrix model, which is established on the basis of a large number of data acquisitions. Simulation results show that the proposed approach can predigest the high dimension vector, which is composed of networks flows, guarantee the detection precision, and reduce the computation consuming. Copyright © 2014 John Wiley & Sons, Ltd.
The Synthesis of Dimeric ReI–Phenylenediimine Conjugates: Spectroscopic and Electrochemical Studies
Authors: Hasheminasab Abed , Engle James T. , Bass Jacob , Herrick Richard S. , Ziegler Christopher J. 
Published: April 2014

AbstractA series of dimeric ReI(CO)3 compounds have been prepared by means of a one‐pot reaction of [Re(CO)5X] (X = Cl, Br), pyridine‐2‐carboxyaldehyde, and o‐, m‐, or p‐phenylenediamine. For the m‐ and p‐substituted phenylenediamine reactions, phenyl‐bridged bis(pyridine‐2‐carbaldimine) compounds of the formula [Re(CO)3X]2(μ‐PPC) [3–7; X = Cl, Br; μ‐PPC = m‐ or p‐phenylene bis(pyridine‐2‐carbaldimine)] were produced, with m‐phenylenediamine forming a mixture of isomers. For reactions with o‐phenylenediamine, multiple products formed (compounds 8–11), which ranged from the desired o‐phenylene bis(pyridine‐2‐carbaldimine) adduct to 2‐pyridylbenzimidazole and bridging dipyridinylquinoxaline complexes. An example of each complex was structurally elucidated by single‐crystal X‐ray methods. The dimeric m‐ and p‐phenylene‐bridged Re(CO)3X compounds, including a sulfonate derivative designed to improve solubility, were investigated for possible photophysical applications through the use of UV/Vis spectroscopy and cyclic voltammetry; the study revealed coupling between the rhenium centers.
C–H Activation at a Bidentate Ligand Coordinated to Palladium(II) – an Electrophilic Attack Supported by an External Base
Authors: Cayir Merve , Ghoochany Leila Taghizadeh , Walli Adam , Busch Mark , Sun Yu , Meyer Franc , Bräse Stefan , Thiel Werner R. 
Published: April 2014

Abstract2‐(2‐Phenylaminopyrimidin‐4‐yl)pyridines undergo C–H activation at the phenyl ring in the ortho position to the amine nitrogen atom when reacted with (PhCN)2PdCl2 and finally form N,N,C‐coordinated palladium(II) complexes in high yields. Five differently substituted complexes were synthesized and characterized by spectroscopy and X‐ray structure analysis. The reaction mechanism for the formation of these complexes was elucidated by kinetic experiments, which allowed the calculation of the activation parameters of the complex formation.
Acrylamide – Still a matter of concern for fried potato food?*
Authors: Matthäus Bertrand , Haase Norbert U. 
Published: April 2014

Acrylamide is a well‐known chemical compound that came into the discussion as food‐borne contaminant in 2002 when the Swedish National Food Administration (NFA) together with the University of Stockholm announced the finding of acrylamide in food for the first time. A lot of research has been done all over the world to elucidate the reaction pathway for the formation of acrylamide during processing, to find mitigation strategies to reduce acrylamide in food and to evaluate the toxicity of acrylamide to humans after consumption of acrylamide containing food. Today, it is known that acrylamide is formed under the conditions of the Maillard reaction with low moisture content and temperature >120°C by the amino acid asparagine in presence of certain α‐dicarbonyl compounds from the Maillard reaction. From this knowledge several set screws became evident for the development of successful mitigation strategies such as choice of appropriate raw material low in precursors, pre‐treatment of the raw material before frying or reducing the frying temperature. Until today no significant correlation between the consumption of acrylamide with food and the occurrence of cancer has been found. The present paper reviews the recent research on these topics with special focus on fried potato food.Practical applications: Formation of acrylamide in fried food is still of concern, and even 12 years after the first communication of acrylamide in processed food a lot of papers are published. The questions of formation, mitigation, toxicity, and exposure are partly answered but on the other side important parts are still open. The paper summarizes the status quo with focus on fried potato products.
Regioselective Hydrodebromination of Polybrominated Indoles
Authors: Chelucci Giorgio , Pinna Gérard A. , Pinna Giansalvo 
Published: April 2014

AbstractThe mixture of sodium borohydride and N,N,N′,N′‐tetramethylethylenediamine in combination with a palladium catalyst is a mild and efficient system for the regioselective hydrodebromination of polybrominated indoles with both N‐donating and N‐withdrawing substituents [N‐methyl‐ and N‐(methoxycarbonyl)indoles, respectively].