bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis, Anticancer, and Antimicrobial Activities of Some New Antipyrine‐Based Heterocycles.
Authors: Riyadh Sayed M. , Kheder Nabila A. , Asiry Ahlam M. 
Published: February 2014

AbstractA series of title compounds of type (III), (IV), (VI), (VIII), or (X) are prepared and tested for their antibacterial and antifungal activities.
ChemInform Abstract: Synthesis and Evaluation of Some Novel Precursors of Oxazolidinone Analogues of Chloroquinoline for their Antimicrobial and Cytotoxic Potential.
Authors: Devi Kavita , Asmat Yumna , Agrawal Meenakshi , Sharma Swapnil , Dwivedi Jaya 
Published: February 2014

AbstractNovel oxazolidinone analogues of chloroquinoline displaying potential antibacterial and antifungal activities are synthesized.
ChemInform Abstract: Regio‐ and Diastereoselective Stepwise [8 + 3]‐Cycloaddition Reaction Between Tropone Derivatives and Donor—Acceptor Cyclopropanes.
Authors: Rivero Alexandra R. , Fernandez Israel , Sierra Miguel Angel 
Published: February 2014

AbstractThe novel [8 + 3]‐cycloaddition reaction between tropone derivatives (I) and aminocyclopropane (II) catalyzed by SnCl4 results in the formation of amino‐substituted tetrahydrocyclohepta[b]pyrans (III) with complete regio‐ and diastereoselectivity.
ChemInform Abstract: A Novel Multicomponent Reaction Involving Isoquinoline, Allenoate and Activated Ketone.
Authors: Yang Hia‐Bin , Zhao Yun‐Zhou , Sang Rui , Tang Xiang‐Yin , Shi Min 
Published: February 2014

AbstractThis novel three component reaction gives an easy access to isoquinoline derivatives via a 1,4‐dipolar cycloaddition reaction.
ChemInform Abstract: Palladium‐Catalyzed, Microwave‐Assisted Synthesis of 3,4‐Dihydro‐3‐oxo‐2H‐1,4‐benzoxazines: An Improved Catalytic System and Multicomponent Process.
Authors: Feng Gaofeng , Wang Shengnan , Li Weiting , Chen Fengjiang , Qi Chenze 
Published: February 2014

AbstractAn improved catalytic system is developed for the reaction of less reactive aryl chlorides (I) with aromatic amines to produce the title compounds (III).
ChemInform Abstract: BN‐Dibenzo[a,o]picenes: Analogues of an Unknown Polycyclic Aromatic Hydrocarbon.
Authors: Neue Benedikt , Araneda Juan F. , Piers Warren E. , Parvez Masood 
Published: February 2014

AbstractThis method yields compounds (III) which are analogues of the so far unreported aromatic hydrocarbon (IV).
ChemInform Abstract: Pyridine‐Directed Palladium‐Catalyzed Phosphonation of C(sp2)—H Bonds.
Authors: Li Changkun , Yano Takaaki , Ishida Naoki , Murakami Masahiro 
Published: February 2014

AbstractThe title reaction occurs through the use of not only pyridine, but also quinoline and pyrimidine as the directing groups.
ChemInform Abstract: Observation of TiH5 and TiH7 in Bulk‐Phase TiH3 Gels for Kubas‐Type Hydrogen Storage.
Authors: Hoang Tuan K. A. , Morris Leah , Reed Daniel , Book David , Trudeau Michel L. , Antonelli David M. 
Published: February 2014

AbstractPorous TiIII hydride gels of type (II) are prepared as promising new hydrogen storage materials exploiting the first example of a solid state homoleptic metal hydride that binds further H2 ligands via the Kubas interaction [→ (III)].
The effect of heart rate reduction with ivabradine on renal function in patients with chronic heart failure: an analysis from SHIFT
Authors: Voors Adriaan A. , van Veldhuisen Dirk J. , Robertson Michele , Ford Ian , Borer Jeffrey S. , Böhm Michael , Komajda Michel , Swedberg Karl , Tavazzi Luigi ,   on behalf of the SHIFT investigators
Published: February 2014

AimsWe studied the relationship between heart rate and renal function and the effects of heart rate reduction with ivabradine in heart failure patients with and without renal dysfunction.Methods and resultsFrom the 6505 patients who were randomized in SHIFT, baseline creatinine and at least one follow‐up measurement were available in 6160 patients. Median follow‐up was 22.9 months. Worsening renal function (WRF) was defined as a creatinine increase of ≥0.3 mg/dL and ≥25% from the baseline value. WRF developed in 1029 (17%) patients and was directly related to baseline heart rate, with an incremental risk of 5% for every 5 b.p.m. heart rate increment (P = 0.003). WRF was associated with an increased risk of the primary composite endpoint of hospitalization for worsening heart failure or cardiovascular death [hazard ratio (HR) 1.38, P < 0.001] and of all‐cause mortality (HR 1.42, P < 0.001). Ivabradine use was associated with a reduction of the primary composite endpoint in patients both with (HR 0.82, P = 0.023) and without renal dysfunction (HR 0.81, P < 0.001) at baseline (P for interaction = 0.89), and tolerability of ivabradine was comparable in the two groups. No differences were found in changes in renal function over time between ivabradine‐ and placebo‐treated patients.ConclusionIn chronic stable systolic heart failure patients, heart rate is directly and independently associated with the risk of WRF, but reduction in heart rate by ivabradine had a neutral effect on renal function during 2 years of follow‐up. The beneficial cardiovascular effects and safety of ivabradine were similar in patients with and without renal dysfunction.
Mapping brain circuit function in vivo using two‐photon fluorescence microscopy
Authors: Bovetti Serena , Moretti Claudio , Fellin Tommaso 
Published: February 2014

ABSTRACTMapping the activity of neuronal circuits with high resolution in the intact brain is a fundamental step toward understanding brain function. In the last several years, nonlinear microscopy combined with fluorescent activity reporters has become a crucial tool for achieving this goal. In this review article, we will highlight the principles underlying nonlinear microscopy and discuss its application to neuroscience, focusing on recent functional studies in the rodent neocortex in combination with genetically encoded calcium indicators. Microsc. Res. Tech. 77:492–501, 2014. © 2014 Wiley Periodicals, Inc.
A complement to potential theory in the Cosserat elasticity
Authors: Cialdea Alberto , Dolce Emanuela , Malaspina Angelica 
Published: February 2014

AbstractIn this paper, we investigate the internal second, third, and fourth boundary value problems of the three‐dimensional Cosserat elasticity by means of potential theory. The obtained integral representations differ from the classical ones. These results complete the ones related to the first BVP, which have recently been obtained by the authors. Copyright © 2014 John Wiley & Sons, Ltd.
High‐order space‐time finite element schemes for acoustic and viscodynamic wave equations with temporal decoupling
Authors: Banks H. T. , Birch Malcolm J , Brewin Mark P , Greenwald Stephen E , Hu Shuhua , Kenz Zackary R , Kruse Carola , Maischak Matthias , Shaw Simon , Whiteman John R 
Published: February 2014

SUMMARYWe revisit a method originally introduced by Werder et al. (in Comput. Methods Appl. Mech. Engrg., 190:6685–6708, 2001) for temporally discontinuous Galerkin FEMs applied to a parabolic partial differential equation. In that approach, block systems arise because of the coupling of the spatial systems through inner products of the temporal basis functions. If the spatial finite element space is of dimension D and polynomials of degree r are used in time, the block system has dimension (r + 1)D and is usually regarded as being too large when r > 1. Werder et al. found that the space‐time coupling matrices are diagonalizable over for r ⩽100, and this means that the time‐coupled computations within a time step can actually be decoupled. By using either continuous Galerkin or spectral element methods in space, we apply this DG‐in‐time methodology, for the first time, to second‐order wave equations including elastodynamics with and without Kelvin–Voigt and Maxwell–Zener viscoelasticity. An example set of numerical results is given to demonstrate the favourable effect on error and computational work of the moderately high‐order (up to degree 7) temporal and spatio‐temporal approximations, and we also touch on an application of this method to an ambitious problem related to the diagnosis of coronary artery disease. Copyright © 2014 The Authors. International Journal for Numerical Methods in Engineering published by John Wiley & Sons Ltd.
All‐electrical detection of spin Hall effect in semiconductors
Authors: Ehlert Markus , Song Cheng , Ciorga Mariusz , Hupfauer Thomas , Shiogai Junichi , Utz Martin , Schuh Dieter , Bougeard Dominique , Weiss Dieter 
Published: February 2014

Since the prediction of the spin Hall effect more than 40 years ago, significant progress was made in theoretical description as well as in experimental observation, especially in the last decade. In this article, we present three different concepts and measurement geometries for all‐electrical detection of the direct and the inverse spin Hall effect in semiconductors. Based on experiments with n‐ and p‐doped GaAs microstructures, we describe our experimental approaches and methods to experimentally identify the spin Hall effect and compare our results to previous experiments and theoretical considerations. Device geometry for the detection of the direct spin Hall effect.
High excitation density recombination dynamics in InGaN/GaN quantum well structures in the droop regime
Authors: Davies Matthew J. , Badcock Tom J. , Dawson Philip , Oliver Rachel A. , Kappers Menno J. , Humphreys Colin J. 
Published: February 2014

AbstractWe report on the low temperature time‐integrated and time‐resolved photoluminescence properties of an (0001) InGaN/GaN multiple quantum well structure. From excitation power dependent studies, we observe a clear correlation between the onset of efficiency droop and the broadening of the time‐integrated luminescence spectra. Time‐resolved spectroscopy reveals that this spectral broadening is associated with a large and rapid red‐shift of the spectrum with increasing time after the excitation pulse. This dynamic shift of the spectrum also modifies the form of the luminescence transients, yet the spectrally integrated luminescence dynamics have the same non‐exponential shape as those obtained under much lower excitation levels. This observation is consistent with the emission originating from the recombination of independently localised carriers, even under very high excitation levels. Nevertheless, at these high excitation levels we propose that there also is a population of weakly localised carriers, probably electrons. We suggest that these more mobile carriers are effective in screening the built‐in electric field across the quantum well as well as being more susceptible to non‐radiative loss. The collapse in this population, due to radiative and non‐radiative recombination, restores the built‐in polarisation induced field and results in the observed time dependent redshift of the luminescence spectrum. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Native seeding and silicon doping in bulk growth of AlN single crystals by PVT method
Authors: Radhakrishnan Sumathi R. 
Published: February 2014

AbstractHomo‐epitaxial growth of AlN crystals using native seeds prepared from our hetero‐epitaxial AlN/SiC template crystals has been successfully carried out. Single crystals of acceptable structural properties with XRD‐RC FWHM of 150 arcsec, Raman E2(high) phonon mode FWHM of 9 cm‐1 and with low concentrations of background impurities (below the detection limit of EPMA) were obtained. An effort has been made to obtain n‐type conductivity in the PVT grown AlN single crystals through intentional Si‐doping during bulk growth. The investigations using EPMA and micro‐Raman measurements confirm that it is possible to incorporate intentionally the Si atoms in the bulk AlN host lattice without any kind of Si inclusions or precipitates. Structural quality of the Si‐doped crystals was almost same as that of the native seed crystal. Si‐doping induces a compressive strain in the doped AlN crystals as seen from the 5 cm–1 shift (blue shift) in the Raman E2(high) peak position. EPR measurement gives first evidence of the presence of shallow level Si donor in the grown crystal, though the free‐carrier concentrations are quite low for a semiconductor doping. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Europium‐doped GaN(Mg): beyond the limits of the light‐emitting diode
Authors: O'Donnell K. P. , Edwards P. R. , Kappers M. J. , Lorenz K. , Alves E. , Boćkowski M. 
Published: February 2014

AbstractRare‐earth doped III‐N semiconductors have been studied for decades on account of their possible application in visible light‐emitting diodes (LED) with built‐in utility as red (e.g. Eu), green (Er) and blue (Tm) monochromatic sources (O'Donnell and Dierolf (eds.), Topics in Applied Physics, Vol. 124 (Springer, Dordrecht, 2010) [1]). However, to date, no commercial devices have been introduced on the basis of these materials. Recently, we discovered thermally activated hysteresis in the emission spectrum of p‐type GaN thin films that were co‐doped with Mg and Eu (O'Donnell et al., Proc. ICPS31, Zurich, July 2012 [2]). We have also reported an unexpected Zeeman splitting and induced magnetic moment of Eu3+ ions in GaN (Kachkanov et al., Scientific Rep. 2, 969 (2012) and MRS Proc. 1290–i03–06 (2011) [3, 4]). These findings encourage speculation on taking the study of RE‐doped III‐N beyond the limited goal of improving LED efficiency into the realm of novel magneto‐optic and quantum‐optical devices. In particular we will describe in this presentation the spectroscopy of ion‐implanted and annealed GaN(Mg): Eu samples and the possible exploitation of the Mg acceptor in GaN as a qubit. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Assessing the Efficiency of an Elver Ladder Using a Multi‐State Mark–Recapture Model
Authors: Drouineau H. , Rigaud C. , Laharanne A. , Fabre R. , Alric A. , Baran P. 
Published: February 2014

AbstractThe decline of the European eel (Anguilla anguilla) stock has led the European Commission to enforce a regulation (Council Regulation N° 1100/2007), in which each member state was required to establish an eel management plan. Various measures in the French plan aim at restoring river connectivity by mitigating the impact of obstacles on the colonization of continental water by eels. Consequently, many obstacles are going to be equipped with elver ladder in the near future. In this context, a method to assess the passability of an obstacle seems essential. In this study, we developed a tag–recapture method, appropriate to glass eels and elvers, and an associated multi‐state mark–recapture model (i) to assess the passability of a ladder and (ii) to quantify the effect of various environmental factors on this passability. An application to a specific obstacle is applied as an illustrative example that demonstrates the relevance of the assessment method, and how the results can be used to propose technical solution to improve the efficiency of the ladder. Nine tag–recapture campaigns were carried on this obstacle, and about 4400 young eels were tagged. The model demonstrates that the efficiency of the ladder was rather low, especially during low river flow periods, mainly because of accessibility problems. The model also demonstrates the major influence of the river flow on the probability for an eel to pass the ladder; consequently, managing river flow during the migration period can be a relevant measure to improve river connectivity and facilitate colonization of the watershed. Copyright © 2014 John Wiley & Sons, Ltd.
Copy Number Variation in CCND1 Gene Is Implicated in the Pathogenesis of Sporadic Parathyroid Carcinoma
Authors: Zhao Lin , Sun Li‐hao , Liu Dong‐mei , He Xiao‐yan , Tao Bei , Ning Guang , Liu Jian‐min , Zhao Hong‐yan 
Published: February 2014

AbstractBackgroundThe molecular bases for parathyroid carcinomas present in conjunction with sporadic primary hyperparathyroidism are not fully elucidated. Gene copy number variations (CNVs) play an important role in tumorigenesis. The aim of the current study was to explore whether the CNVs of specific tumor‐associated genes are involved in parathyroid carcinogenesis.MethodsA multiplex ligation‐dependent probe amplification method was used to compare differences in copy number in 39 common tumor‐associated genes among 7 patients with parathyroid carcinoma and 14 age‐ and sex‐matched subjects with parathyroid adenoma.ResultsIt was shown that amplification of CCND1, a gene encoding cyclin D1, was more prevalent in parathyroid carcinomas than in adenomas (71 vs. 21 %, p = 0.056). This result was confirmed quantitatively by real‐time polymerase chain reaction. Expression of CCND1 mRNA level was significantly higher in carcinomas than in adenomas (p = 0.003). Western blot and immunohistochemical analysis also demonstrated higher expression of CCND1 in carcinoma specimens than in adenoma samples.ConclusionsIt is thus inferred that gain in copy number of CCND1 is implicated in the molecular pathogenesis of parathyroid carcinoma.
Personalized Genomic Results: Analysis of Informational Needs
Authors: Schmidlen Tara J. , Wawak Lisa , Kasper Rachel , García‐España J. Felipe , Christman Michael F. , Gordon Erynn S. 
Published: February 2014

AbstractUse of genomic information in healthcare is increasing; however data on the needs of consumers of genomic information is limited. The Coriell Personalized Medicine Collaborative (CPMC) is a longitudinal study investigating the utility of personalized medicine. Participants receive results reflecting risk of common complex conditions and drug—gene pairs deemed actionable by an external review board. To explore the needs of individuals receiving genomic information we reviewed all genetic counseling sessions with CPMC participants. A retrospective qualitative review of notes from 157 genetic counseling inquiries was conducted. Notes were coded for salient themes. Five primary themes; “understanding risk”, “basic genetics”, “complex disease genetics”, “what do I do now?” and “other” were identified. Further review revealed that participants had difficulty with basic genetic concepts, confused relative and absolute risks, and attributed too high a risk burden to individual single nucleotide polymorphisms (SNPs). Despite these hurdles, counseled participants recognized that behavior changes could potentially mitigate risk and there were few comments alluding to an overly deterministic or fatalistic interpretation of results. Participants appeared to recognize the multifactorial nature of the diseases for which results were provided; however education to understand the complexities of genomic risk information was often needed.
Adalimumab versus infliximab for the treatment of moderate to severe ulcerative colitis in adult patients naïve to anti-TNF therapy: An indirect treatment comparison meta-analysis
Authors: Thorlund Kristian , Druyts Eric , Mills Edward J. , Fedorak Richard N. , Marshall John K. 
Published: February 2014

Abstract

Objective
To compare the efficacy of adalimumab and infliximab for the treatment of moderate to severe ulcerative colitis using indirect treatment comparison meta-analysis.

Methods
A systematic review and Bayesian indirect treatment comparison meta-analyses were performed for seven patient-important clinical outcomes at 8 weeks and 52 weeks. Odds ratio (OR) estimates and associated 95% credible intervals (CrIs) were produced.

Results
Five eligible RCTs informed clinical remission, response, mucosal healing, quality of life, colectomy, serious adverse events, and discontinuation due to adverse events at 8 weeks and 52 weeks. At 8 weeks of induction therapy, clinical remission (OR = 0.42, 95% CrI 0.17–0.97), clinical response (OR = 0.45, 95% CrI 0.23–0.89) and mucosal healing (OR = 0.46, 95% CrI 0.25–0.86) statistically favored infliximab. However, after 52 weeks of maintenance therapy OR estimates showed no significant difference between infliximab and adalimumab. For serious adverse events and discontinuations due to adverse events, adalimumab and infliximab were similar to placebo. Further, the indirect treatment comparison of adalimumab and infliximab yielded odds ratios close to 1.00 with wide credible intervals.
Relative Specificity: All Substrates Are Not Created Equal
Authors: Zeng Yan 
Published: February 2014

Abstract
A biological molecule, e.g., an enzyme, tends to interact with its many cognate substrates, targets, or partners differentially. Such a property is termed relative specificity and has been proposed to regulate important physiological functions, even though it has not been examined explicitly in most complex biochemical systems. This essay reviews several recent large-scale studies that investigate protein folding, signal transduction, RNA binding, translation and transcription in the context of relative specificity. These results and others support a pervasive role of relative specificity in diverse biological processes. It is becoming clear that relative specificity contributes fundamentally to the diversity and complexity of biological systems, which has significant implications in disease processes as well.
A point‐based tool to predict conversion from mild cognitive impairment to probable Alzheimer's disease
Authors: Barnes Deborah E. , Cenzer Irena S. , Yaffe Kristine , Ritchie Christine S. , Lee Sei J. ,   Alzheimer's Disease Neuroimaging Initiative
Published: February 2014

AbstractBackgroundOur objective in this study was to develop a point‐based tool to predict conversion from amnestic mild cognitive impairment (MCI) to probable Alzheimer's disease (AD).MethodsSubjects were participants in the first part of the Alzheimer's Disease Neuroimaging Initiative. Cox proportional hazards models were used to identify factors associated with development of AD, and a point score was created from predictors in the final model.ResultsThe final point score could range from 0 to 9 (mean 4.8) and included: the Functional Assessment Questionnaire (2‒3 points); magnetic resonance imaging (MRI) middle temporal cortical thinning (1 point); MRI hippocampal subcortical volume (1 point); Alzheimer's Disease Cognitive Scale—cognitive subscale (2‒3 points); and the Clock Test (1 point). Prognostic accuracy was good (Harrell's c = 0.78; 95% CI 0.75, 0.81); 3‐year conversion rates were 6% (0‒3 points), 53% (4‒6 points), and 91% (7‒9 points).ConclusionsA point‐based risk score combining functional dependence, cerebral MRI measures, and neuropsychological test scores provided good accuracy for prediction of conversion from amnestic MCI to AD.
The impact of cultural differences on buyer–supplier negotiations: An experimental study
Authors: Ribbink Dina , Grimm Curtis M. 
Published: February 2014

AbstractIn today's global economy, an ever‐increasing number of companies are dealing with international partners, instigating a need to understand the impact of cultural differences on business interactions. Using Hall's distinction of high‐ and low‐context culture, this study investigates the direct and moderating effects of cultural differences in dyadic buyer–supplier negotiations. Theory is developed regarding the impact of culture on joint profits, juxtaposing Transaction Cost Economics and the Relational View. The theory is tested with a negotiation experiment. Participants, classified by their country of origin, negotiate prices and quality levels for three products. This study finds that cultural differences within the negotiation dyad reduce joint profits when compared to dyads of participants with similar cultural backgrounds. Cultural differences also moderate the impact of trust and bargaining strategy on joint profits. Overall, this study concludes that cultural differences, as encountered in day‐to‐day business interactions in global supply chains, significantly impact negotiation outcomes.