bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mxene-bpV plays a neuroprotective role in cerebral ischemia-reperfusion injury by activating the Akt and promoting the M2 microglial polarization signaling pathways
Authors: Cheng Jing , Yu Han , Zhang Zhi-Feng , Jiang Hong-Xiang , Wu Ping , Wang Zhou-Guang , Chen Zhi-Biao , Wu Li-Quan 
Published: July 2024

AbstractStudies have shown that the inhibition of phosphatase and tensin homolog deleted on chromosome 10 (PTEN)was neuroprotective against ischemia/reperfusion(I/R) injury. Bisperoxovanadium (bpV), a derivative of vanadate, is a well-established inhibitor of PTEN. However, its function islimited due to its general inadequacy in penetrating cell membranes. Mxene(Ti3C2Tx) is a novel two-dimensional lamellar nanomaterial with an excellent ability to penetrate the cell membrane. Yet, the effects of this nanomaterial on nervous system diseases have yet to be scrutinized. Here, Mxene(Ti3C2Tx) was used for the first time to carry bpV(HOpic), creating a new nanocomposite Mxene-bpV that was probed in a cerebral I/R injury model. The findings showed that this synthetic Mxene-bpV was adequately stable and can cross the cell membraneeasily. We observed that Mxene-bpV treatment significantly increased the survival rate of oxygen glucose deprivation/reperfusion(OGD/R)--insulted neurons, reduced infarct sizes and promoted the recovery of brain function after mice cerebral I/R injury. Crucially, Mxene-bpV treatment was more therapeutically efficient than bpV(HOpic) treatment alone over the same period. Mechanistically, Mxene-bpV inhibited the enzyme activity of PTEN in vitro and in vivo. It also promoted the expression of phospho-Akt (Ser473) by repressing PTEN and then activated the Akt pathway to boost cell survival. Additionally, in PTEN transgenic mice, Mxene-bpV suppressed I/R-induced inflammatory response by promoting M2 microglial polarization through PTEN inhibition. Collectively, the nanosynthetic Mxene-bpV inhibited PTEN’ enzymatic activity by activating Akt pathway and promoting M2 microglial polarization, and finally exerted neuroprotection against cerebral I/R injury.
Graphical Abstract
The offer framing effect: a replication and extension
Authors: Pfeifer Louisa M. , Schreiner Thomas F. 
Published: July 2024

AbstractThe article by Mittelman et al. (2014, Journal of Consumer Research, 41(4):953–964) introduced the offer framing effect, suggesting that consumers exhibit greater variety-seeking behavior when selecting products sequentially (single offering) compared to choosing from bundles (bundled offering). The opposite was found by O’Donnell et al. (2023, Journal of Consumer Research, 49(5):861–881), resulting in opposing management implications. To clarify the direction of effect, we conducted four studies in two product categories and found evidence of a stronger preference for variety in bundled offering conditions (compared to single offering conditions), replicating O’Donnell et al.’s (2023) findings. However, utilizing logistic regression analyses, we identify product liking discrepancies as the primary driver of variety seeking. We further reveal that the offer framing effect is more distinctive for choices between products with prosocial attributes compared to hedonic attributes. Our findings provide valuable insights for marketers aiming to optimize product bundling strategies.
Decreased Metal Dusting Resistance of Ni-Cu Alloys by Fe and Mn Additions
Authors: Ulrich Anke S. , Kasatikov Sergey , König Till , Fantin Andrea , Margraf Johannes T. , Galetz Mathias C. 
Published: July 2024

AbstractNi-Cu alloys are promising for application at temperatures between 400–900 °C and reducing atmospheres with high C-contents. Typically, under such conditions, metallic materials in contact with the C-rich atmosphere are degraded by a mechanism called metal dusting (MD). Ni-Cu-alloys do not form protective oxide scales, but their resistance is attributed to Cu, which catalytically inhibits the C-deposition on the surface. Adding other alloying elements, such as Mn or Fe, was found to enhance the MD attack of Ni-Cu alloys again. In this study, the effect of the Mn and Fe is divided into two affected areas: the surface and the bulk. The MD attack on binary Ni-Cu alloys, model alloys with Fe and Mn additions, and commercial Monel Alloy 400 is experimentally demonstrated. The surface electronic structure causing the adsorption and dissociation of C-containing molecules is investigated for model alloys. Analytical methods such as scanning electron microscopy combined with energy-dispersive X-ray spectroscopy, electron probe microanalysis combined with wavelength-dispersive X-ray spectroscopy, X-ray diffraction analysis, and near-edge X-ray absorption fine structure measurements were used. The results are correlated to CALPHAD calculations and atomistic simulations combining density functional theory calculations and machine learning. It is found that the Cu content plays a significant role in the surface reaction. The effect of Mn and Fe is mainly attributed to oxide formation. A mechanism explaining the enhanced attack by adding both Fe and Mn is proposed.
3D-Printed Meat Paste Using Minimal Additive: Assessment of Rheological and Printing Behavior with Post-Processing Stability
Authors: Yatmaz Hanife Aydan 
Published: July 2024

AbstractPrinting foods in the desired shape with minimal additives and their stability after printing are the most important points for 3D food technology. In this study, the effects of water (5%, 10%, 15%, and 20%) and salt (0.5%, 1%, 1.5%, and 2%) on the printability of meat paste were evaluated to achieve improved textural and rheological properties. The printing parameters were examined at every stage, starting from the line thickness of the printed product, until the final 3D printed product was obtained. Accordingly, meat printability determined using different ingredient flow speed (3, 3.5, 4, 4.5, and 5), fill factor (1.2%, 1.3%, 1.4%, 1.5%, and 1.6%) and distance between layers (1.2, 1.4, and 1.6 mm). Salt addition increased the firmness and consistency of the samples, while the viscosity, storage modulus, and loss modulus decreased with the addition of water. Considering the line thickness and outer length, the most appropriate shape was obtained with 10% water and 1.5% salt. The optimal ingredient flow speed, fill factor, and distance between layers at a constant printing speed (2500 mm/min) were 3, 1.2%, and 1.4 mm, respectively. Four-layer-infilled 3D-printed samples maintained their initial shape after cooking, regardless of the cooking method. However, only baked products maintained their initial shapes among full-infilled samples. Although water and salt have different functions in meat, the use of the appropriate ratio is necessary for 3D-printed meat-based products to provide printability and post-production stability. To sum up optimum parameters and road map for printing meat and meat products including leftover meats and low-value by-products were revealed.
Negotiable fate-engagement relationship in higher education: The mediation role of hope for success and fear of failure
Authors: Yau Oscar K. T. , Shu Tse-Mei 
Published: July 2024

AbstractStudies concerning students’ ability to deal with everyday academic challenges (‘academic buoyancy’) and adjust to changes (‘adaptability’) were investigated in educational research over the last two decades (e.g., Martin & Marsh, Journal of School Psychology, 46:53–83, 2008; Martin et al., Journal of Educational Psychology, 105:728–746, 2013). However, how students deal with challenges imposed by fate has not been well-studied. Other than students’ abilities, students’ belief plays an important role in dealing with the academic adversity that fate imposes. The present study harnessed the Hope Theory to examine (1) the relation between negotiable and achievement motivation (hope for success and fear of failure), (2) the relation between achievement motivation and engagement, and (3) the mediation effect of achievement motivation in the relation between negotiable fate and engagement. University students in Hong Kong (n = 339) responded to an online cross-sectional survey. Mediation analyses demonstrated that the relation between negotiable fate and engagement was mediated by hope for success but not by fear of failure. In addition, hope for success only mediated cognitive engagement and affective engagement. The relation between negotiable fate and behavioral engagement was not mediated by hope for success and fear of failure. The findings contribute to the literature on the negotiable fate-engagement theoretical relation in educational research. Also, practical insights were discussed to manage student cognitive and affective engagement with negotiable fate and hope for success under fate constraints.
Technological variability in El Castillo cave during MIS 4
Authors: González-Molina Irene , Maíllo-Fernández José-Manuel , Vaquero Manuel , Neira Ana , Bernaldo de Quirós Federico , Marín Juan 
Published: July 2024

AbstractThe variability in Neanderthal behaviour is one of the key debates in Middle Palaeolithic archaeology. Here we present the analysis of the lithic industry from a unit at one of Europe’s main Palaeolithic sites: El Castillo Cave. Unit XXf1.1, dated to the beginning of MIS 4, is an example of human occupation during a period of population decrease. In this assemblage, the technology is organised with the aim of obtaining the largest possible blanks in an environment in which small-sized raw materials predominate, with the presence of imported tools and clear differences in the management of different raw materials. This assemblage is characterized by the predominance of centripetal exploitation methods, and there is only a small number of blanks with laminar tendency, and cleavers. From all this we can observe how Neanderthals were able to find ways to achieve their specific objectives, planning their behaviour to overcome the limitations imposed by the environment.
A comprehensive health index for India: development, validation, and spatial variation
Authors: Sehgal Meena , Jatrana Santosh , Johnson Louise 
Published: July 2024

AbstractThis paper presents the development, testing, and spatial variation of an innovative India Health Index. Unlike previous approaches that focused on specific health aspects (e.g., health resources, child health, or health coverage), our index takes a comprehensive and multi-dimensional approach. It covers indicators across various life stages: child, adolescent, and adult. It encompasses six domains influencing health: socio-cultural factors, health status, health determinants (both risk and protective factors), household environment, and health system and policy. We used data from the latest round of the National Family Health Survey and employed Principal Component Analysis for constructing the India Health Index. Subsequent statistical tests confirmed its internal reliability and construct validity. External validity was indicated by its association with under-five mortality rates, and the sub-national human development index for India. Spatial analyses revealed significant inter-district and inter-state variation in India Health Index scores. The findings underscore the utility of the India Health Index as a measurement tool and its potential for tracking progress and policy intervention for improving health equity in India.
Rivers as categories of order. A methodical assessment of the position of art geography
Authors: Trinkert Julia 
Published: July 2024

AbstractIn art history, rivers are used to describe relational spatial constellations which enable the spatial distribution of specific styles of artworks in a topographical classification. River courses are used to delimit the distribution areas of buildings or objects of different genres in order to define artistic landscapes. According to this spatial concept, medieval wooden sculptures, for example, can be found between the Eider and Königsau (Danish Kongeå) and Romanesque churches can be found on the Meuse and Rhine, each with artistic characteristics which—as cultural units—can seldom be found beyond their designated natural borders. This article examines the methodological position of art geography, its role today and its potential for art history in general. Accordingly, it will present the broad outlines of the historiographical development of this field, summarise the current focal points and discuss application-oriented perspectives for medieval art history, taking digital humanities, in particular, into account.
The effect of irrigation with magnetized wastewater on soil heavy metals, water productivity and heavy metals in aerial parts and grains of maize
Authors: Khoshravesh Mojtaba , Pourgholam-Amiji Masoud 
Published: July 2024

AbstractRising population strains food resources; reusing wastewater increases but brings microbial and heavy metal pollution, impacting nature and human health. Among environmental pollutants, heavy metals in wastewater are a major concern. Using magnetized water is a method to improve water and soil quality. The aim of this research is to investigate the effect of using treated magnetized wastewater on the chemical properties and tracking of heavy metals in the soil, performance and yield components, water efficiency, and absorption of heavy metals by maize plant. Irrigation treatments consisted of various water and wastewater blending ratios under both magnetic and non-magnetic field application conditions. The results showed that the effect of irrigation water and mixing of water and wastewater on electrical conductivity, soil salts and heavy metals in different depths were significant at 1% probability level. On average, irrigation with magnetized wastewater caused a significant increase in grain yield (9.8%) and biological yield of maize (10.63%) compared to non-magnetized wastewater treatment. Irrigation with magnetized wastewater caused a significant increase in biological (10.92%) and physical (10.13%) productivities compared to non-magnetized wastewater treatment. With applying a magnetic field resulted in a reduction of 17.99%, 23.25%, 17.86%, and 17.12% in the concentration of lead, cadmium, zinc, and nickel in the aerial parts of the plant, respectively, compared to the non-magnetized water treatment. Magnetized water increases the water use efficiency of maize and irrigation management with this technology can be useful in more effective and economical use of limited water resources.
Analysis of different objective functions in petroleum field development optimization
Authors: Rostamian Auref , de Sousa Miranda Marx Vladimir , Mirzaei-Paiaman Abouzar , Botechia Vinicius Eduardo , Schiozer Denis José 
Published: July 2024

AbstractOilfield development optimization plays a vital role in maximizing the potential of hydrocarbon reservoirs. Decision-making in this complex domain can rely on various objective functions, including net present value (NPV), expected monetary value (EMV), cumulative oil production (COP), cumulative gas production (CGP), cumulative water production (CWP), project costs, and risks. However, EMV is often the main function when optimization is performed under uncertainty. The behavior and performance of different objective functions has been investigated in this paper, when EMV is the primary criterion for optimization under reservoir and economic uncertainty. One of the goals of this study is to provide insights into the advantages and limitations of employing EMV as the sole objective function in oil field development decision-making. The designed optimization problem included sequential optimization of design variables including well positions, well quantity, well type, platform capacity, and internal control valve placements. A comparative analysis is presented, contrasting the outcomes obtained from optimizing the EMV-based objective function against traditional objective functions. The study underscores the importance of incorporating multiple objective functions alongside EMV to guide decision-making in oilfield development. Potential benefits in minimizing CGP and CWP are revealed, aiding in the mitigation of environmental impact and optimization of resource utilization. A strong correlation between EMV and COP is identified, highlighting EMV’s role in improving COP and RF.
Classification of DNA Mixtures by Nanoelectrokinetic Driftless Preconcentration
Authors: Baek Seongho , Park Jihee , Sung Hobin , Lee Jung Ae , Kim Man Jin , Seong Moon-Woo , Kim Sung Jae 
Published: July 2024

AbstractNanofluidic phenomena, particularly Ion Concentration Polarization (ICP), have been actively utilized for advancing various research fields, including chemical analysis and biomedical diagnostics, over the past century. While ICP can be used as effective preconcentration techniques in bio-/chemical analysis, there are few studies to investigate the shape of preconcentration plug, especially perpendicular distribution of analyte in the preconcentration plug. Previously we have reported the theoretical analysis of the distribution so that the types of plug were categorized as dumbbell or plug shape. In this study, we further investigated the classification of real DNAs within micro-/nanofluidic devices by examining the preconcentration dynamics of different DNA types under diverse electrical conditions. Our investigation successfully distinguished distinct preconcentration profiles for Short DNA, Multi-short DNAs, and Equitable DNA with introducing the concept of the Radius of Gyration for Fluorescence (RGF). We provided a quantitative framework to analyze and differentiate preconcentration shapes with reasonable precision. These findings not only deepen our understanding of DNA preconcentration dynamics but also provide implications for genetic diagnostics. As a simpler and more accessible pre-test tool, our research could be utilized as the efficient genetic testing, particularly in diagnosing disorders characterized by variations in DNA length.
Placing Islands at Risk: Developmentalism, Militarism, Geopolitics, and the Sendai Framework for Disaster Risk Reduction
Authors: Grydehøj Adam , Xu Jin , Su Ping 
Published: July 2024

AbstractIslands have come to be seen as a distinct object of disaster risk and climate change policy and research. This is reflected in the Sendai Framework for Disaster Risk Reduction 2015–2030 (SFDRR), which specifies Small Island Developing States (SIDS) as in need of specialized policies, attention, and support. This article directs an island studies perspective toward the SFDRR, discussing obstacles to the framework’s implementation in island contexts. Focus is placed on two interrelated sets of issues: (1) problematic aspects of the concepts of “development” as it is applied to islands (particularly in the SIDS category); and (2) international cooperation, militarism, and geopolitics. The study found that although island societies can benefit from the attention brought to them by the SFDRR, the framework engages in rhetoric that may limit island possibilities and potentials while distracting from more fundamental changes that should be made by other state and non-state actors.
Digital Expressions of Grief and Mourning between Music, Language and Speechlessness
Authors: Mattfeldt Anna 
Published: July 2024

AbstractA variety of music videos are available on the video platform YouTube, many of which can be commented on. This paper focuses on a certain type of commentary that links a piece of music with memories of deceased relatives or friends. For some users, listening to particular pieces of music consciously, after the experience of a personal loss, appears to be a self-chosen form of processing emotions, which may then be shared anonymously with others in the comment section. These forms of remembrance in turn often garner responses in the anonymity of the comment section voicing sympathy, empathy or one’s own memories. The paper presents linguistic patterns of this digital mourning and the chosen linguistic forms of reactions. This qualitative analysis draws on the comment section of music videos on YouTube, followed by a methodological discussion of the role of music in this »multimodal ensemble« (Stöckl 2019, p. 60) with respect to emotions.
»Ist es obszön, einen Abschiedsbrief an ein Haustier zu schreiben?« – Tiere als Adressat*innen in (offenen) Briefen und (anderen) Social Media-Formaten
Authors: Steen Pamela , Gnau-Franké Birte C. 
Published: July 2024

ZusammenfassungIn diesem medienlinguistischen Beitrag untersuchen wir Adressierungen von (›Heim‹-)Tieren in ›Tierbriefen‹ und verschiedenen Social Media-Formaten und zeigen, inwiefern diese Texte Ausdruck eines emotionalen Kapitals in Bezug auf medialehumanimalischeEmotionsgemeinschaften und Identitätskonstruktionen sind. Aus der Perspektive einer Tierlinguistik, die im Anschluss an die Human-Animal Studies Tiere in theoretischer Hinsicht prinzipiell als gleichwertige soziale Akteur*innen versteht, werden medialisierte Tiere als Quasi-Subjekte/-Objekte konzeptualisiert, die in der sozialen Online-Interaktion unterschiedliche kommunikative Rollen einnehmen. Damit gehen verschiedene Formen des menschlichen tiergerichteten Kommunizierens einher, die als kommunikative Praktiken beschreibbar sind.
Partizipationsvorstellungen von Bürger:innen: Eine explorative Anwendung der Draw&Write-Technik als Survey-Instrument
Authors: Heinrich Horst-Alfred 
Published: July 2024

ZusammenfassungIn einer bayernweiten postalischen Umfrage wurden unter Anwendung der Draw&Write-Technik die Zielpersonen gebeten, ihre Vorstellung von Demokratie zu zeichnen. Eine Bildtypenanalyse ergab zwar, dass die Bilder im erhobenen Datensatz die große Bedeutung bestätigen, die der Wahl in der Demokratie zukommt. Doch führt die in diesem Bereich neue Methode zu beachtlichen Differenzen verglichen mit den Ergebnissen standardisierter Umfragen. Der Mehrwert der Draw&Write-Technik zeigt sich darin, dass das Datenmaterial nicht nur die bekannten Kategorien der repräsentativen, direktdemokratischen, deliberativen oder demonstrativen Beteiligung spiegelt. Ein Teil der Zeichnungen wurde zwei weiteren Kategorien zugeordnet: 1) Klagen über empfundene Ohnmacht und Einflusslosigkeit angesichts eines repräsentativen Herrschaftssystems sowie 2) Appelle an Konsensfähigkeit und die Bereitschaft zur Verantwortungsübernahme als Bedingungen, die die Bürger:innen erfüllen müssen, wenn Beteiligung am politischen Prozess gelingen soll. Weiterhin ist das Ergebnis von großem Wert, weil das Zeichnen im Rahmen eines postalischen Surveys genutzt wurde. Ein Bias besteht lediglich hinsichtlich der Bildungsvariable, was aber auch bei der Anwendung offener Fragen zu erwarten wäre.