bluuebunny/crossref_metadata_2025_split huggingface dataset:
Younger and older chronic somatoform pain patients in psycho-diagnostics, physician-patient relationship and treatment outcome
Authors: Bergander Bernd , Erdur Laurence , Kallenbach-Dermutz Bettina , Deter Hans-Christian 
Published: February 2013

Abstract

Introduction
Patients with chronic pain are found with highly variable clinical presentation and differing physical complaints. They are seen as a heterogenic group. Based on clinical observations, elderly patients seem to differ from younger patients with chronic pain. We examined whether there were systematic differences between young and old pain patients.

Methods
As part of a routine evaluation of university hospital care, a newly developed psychosomatic treatment model for chronic somatoform pain disorders was examined. The basis for treatment efficacy was a target-oriented, specific somatic and psychological intervention that included a stable physician-patient relationship. Particular attention was paid to differences in treatment outcome with regard to changes in both physical and psychopathological symptom levels. We hypothesised that younger pain patients had higher psychological burden and benefitted more from our treatment than older pain patients.

Results
Overall, 179 inpatients (57.5% women) with chronic pain were examined (age between 16 and 79 years). The group as a whole yielded high scores on the somatisation dimension (SCL-90) and showed a considerable amount of psychopathological symptoms, such as depressive mood and anxiety (HADS) and a great emotional instability (FPI-R). Age differences were only found with regards to patients’ degree of aggression (SCl-90): younger patients showed higher aggressive tendencies than older ones (p< 0.05). The treatment offered helped patients in both age groups especially with regard to reduction of depressive mood (HADS, p< 0.01) and anxiety levels (HADS, p< 0.01). Regression analysis showed different age groups and gender as significant predictors of anxiety reduction under therapy (R2=.108; model: p< 0.01).

Discussion and conclusion
Results show that younger chronic pain patients suffer more from a considerable amount of psychological distress than older ones, but our treatment approach was equally effective in both groups. However, age and gender differences, as well as the patient’s baseline level of anxiety influenced the outcome. These factors need to be studied in future research.
New solvation free energy function comprising intermolecular solvation and intramolecular self-solvation terms
Authors: Choi Hwanho , Kang Hongsuk , Park Hwangseo 
Published: February 2013

Abstract
Solvation free energy is a fundamental thermodynamic quantity that should be determined to estimate various physicochemical properties of a molecule and the desolvation cost for its binding to macromolecular receptors. Here, we propose a new solvation free energy function through the improvement of the solvent-contact model, and test its applicability in estimating the solvation free energies of organic molecules with varying sizes and shapes. This new solvation free energy function is constructed by combining the existing solute-solvent interaction term with the self-solvation term that reflects the effects of intramolecular interactions on solvation. Four kinds of atomic parameters should be determined in this solvation model: atomic fragmental volume, maximum atomic occupancy, atomic solvation, and atomic self-solvation parameters. All of these parameters for total 37 atom types are optimized by the operation of a standard genetic algorithm in such a way to minimize the difference between the experimental solvation free energies and those calculated by the solvation free energy function for 362 organic molecules. The solvation free energies estimated from the new solvation model compare well with the experimental results with the associated squared correlation coefficients of 0.88 and 0.85 for training and test sets, respectively. The present solvation model is thus expected to be useful for estimating the solvation free energies of organic molecules.
A role for RNA post-transcriptional regulation in satellite cell activation
Authors: Farina Nicholas H , Hausburg Melissa , Betta NicoleDalla , Pulliam Crystal , Srivastava Deepak , Cornelison DDW , Olwin Bradley B 
Published: February 2013

Abstract

Background
Satellite cells are resident skeletal muscle stem cells responsible for muscle maintenance and repair. In resting muscle, satellite cells are maintained in a quiescent state. Satellite cell activation induces the myogenic commitment factor, MyoD, and cell cycle entry to facilitate transition to a population of proliferating myoblasts that eventually exit the cycle and regenerate muscle tissue. The molecular mechanism involved in the transition of a quiescent satellite cell to a transit-amplifying myoblast is poorly understood.

Methods
Satellite cells isolated by FACS from uninjured skeletal muscle and 12 h post-muscle injury from wild type and Syndecan-4 null mice were probed using Affymetrix 430v2 gene chips and analyzed by Spotfiretm and Ingenuity Pathway analysis to identify gene expression changes and networks associated with satellite cell activation, respectively. Additional analyses of target genes identify miRNAs exhibiting dynamic changes in expression during satellite cell activation. The function of the miRNAs was assessed using miRIDIAN hairpin inhibitors.

Results
An unbiased gene expression screen identified over 4,000 genes differentially expressed in satellite cells in vivo within 12 h following muscle damage and more than 50% of these decrease dramatically. RNA binding proteins and genes involved in post-transcriptional regulation were significantly over-represented whereas splicing factors were preferentially downregulated and mRNA stability genes preferentially upregulated. Furthermore, six computationally identified miRNAs demonstrated novel expression through muscle regeneration and in satellite cells. Three of the six miRNAs were found to regulate satellite cell fate.

Conclusions
The quiescent satellite cell is actively maintained in a state poised to activate in response to external signals. Satellite cell activation appears to be regulated by post-transcriptional gene regulation.
Management of hypersensivity pneumonitis
Authors: Agache Ioana O , Rogozea Liliana 
Published: February 2013

AbstractHypersensitivity pneumonitis (HP) is an interstitial lung disease due to a combined type III and IV reaction with a granulomatous inflammation, caused by cytotoxic delayed hypersensitivity lymphocytes, in a Th1/Th17 milieu, chaperoned by a deficient suppressor function of T regulatory cells. Skewing toward a Th2 phenotype is reported for chronic HP. Phenotypic expression and severity depends on environmental and/or host genetic and immune co‐factors. The wide spectrum of causative antigens is continuously up‐dated with new sources of airborne organic particles and drug‐induced HP. The diagnosis requires a detailed history, measurement of environmental exposure, pulmonary function tests, imaging, detection of serum specific antibodies, broncho‐alveolar lavage, antigen‐induced lymphocyte proliferation, environmental or laboratory‐controlled inhalation challenge and lung biopsy. Complete antigen avoidance is the best therapeutic measure, although very difficult to achieve in some cases. Systemic steroids are of value for subacute and chronic forms of HP, but do not influence long term outcome. Manipulation of the immune response in HP holds future promise.
Bio and health informatics meets cloud : BioVLab as an example
Authors: Chae Heejoon , Jung Inuk , Lee Hyungro , Marru Suresh , Lee Seong-Whan , Kim Sun 
Published: February 2013

Abstract

Abstract
The exponential increase of genomic data brought by the advent of the next or the third generation sequencing (NGS) technologies and the dramatic drop in sequencing cost have driven biological and medical sciences to data-driven sciences. This revolutionary paradigm shift comes with challenges in terms of data transfer, storage, computation, and analysis of big bio/medical data. Cloud computing is a service model sharing a pool of configurable resources, which is a suitable workbench to address these challenges. From the medical or biological perspective, providing computing power and storage is the most attractive feature of cloud computing in handling the ever increasing biological data. As data increases in size, many research organizations start to experience the lack of computing power, which becomes a major hurdle in achieving research goals. In this paper, we review the features of publically available bio and health cloud systems in terms of graphical user interface, external data integration, security and extensibility of features. We then discuss about issues and limitations of current cloud systems and conclude with suggestion of a biological cloud environment concept, which can be defined as a total workbench environment assembling computational tools and databases for analyzing bio/medical big data in particular application domains.
Hybrid RBF and local ϕ-polynomial freeform surfaces
Authors: Kaya Ilhan , Rolland Jannick P. 
Published: February 2013

Abstract
Advances in slow-servo single point diamond turning enables fabrication of freeform optical elements. Freeform optical elements, which are by definition rotationally non-symmetric, will have a profound importance in the future of optical technology. Historically, orthogonal polynomials added onto conic sections have been extensively used for description of optical surface shapes. More recently, local shape descriptors, specifically radial basis functions, have been investigated for optical shape description. In this paper, we reveal an efficient and accurate localized hybrid method combining in one implementation assets of both radial basis functions and ϕ-polynomials for freeform shape description, uniquely applicable across any aperture shape. Initial results show that the proposed method yields subnanometer accuracy with as few as 25 terms of ϕ-polynomials. Subnanometer accuracy is required for the stringent conditions of lithography and related precision optics applications. Less stringent conditions are also shown to be achieved with as few as 16 terms ϕ-polynomials.
Q and A tutorial on optical design
Authors: Livshits Irina , Vasilyev Vladimir 
Published: February 2013

Abstract
There are many good books for optical designers, so we decided not to repeat basic and classical issues, but to answer frequently asked questions which students have put to us during our long-time teaching experience in optical design on different levels – from very beginners to advanced professionals from the EU who came for the project SMETHODS to improve their design skills. This tutorial is divided into two parts: general questions and examples, when students ask how to design some popular schemes.
The twinning of two closely related phenylisoxazoles interpreted according to order-disorder theory
Authors: Stöger Berthold , Pokorny Barbara , Lumpi Daniel , Zobetz Erich , Fröhlich Johannes 
Published: February 2013

Abstract
The closely related 5-[(1Z)-2-(methylthio)-1-propen-1-yl]-3-(4-nitrophenyl)isoxazole (I) and 3-(4-methoxyphenyl)-5-[(1Z)-2-(methylthio)-1-propen-1-yl]isoxazole (II) were synthesized by consecutive ring fragmentation and cycloaddition and their crystal structures were determined by X-ray single crystal diffraction at 100 K. Both compounds are twinned by mirroring at (100). The nitrophenyl (I) [P21/c, Z = 8, Z′ = 2, a = 32.1827(10) Å, b = 5.5992(2) Å, c = 13.9145(4) Å, β = 102.2428(14)°, R
obs = 0.048, 6408 F data, 344 parameters] crystallizes as an order-disorder (OD) structure of one kind of layers. The twin individuals are polytypes of a maximum degree of order (MDO). The twin boundary is interpreted as a triple of adjacent layers of the second MDO polytype. The methoxyphenyl (II) [P21/c, Z = 4, Z′ = 1, a = 16.0545(7) Å, b = 5.6575(3) Å, c = 13.8891(7) Å, β = 94.334(3)°, R
obs = 0.039, 3365 F data, 164 parameters] can be described as an OD structure composed of two kinds of layers, made up of —CH2—-fragments of the S-methyl groups and the remaining parts of the (II) molecules, respectively. Of the four MDO polytypes, one corresponds to the twin individuals. The twin boundary is composed of layer triples of either of two other MDO polytypes.
Acid Fracturing: Fully 3D Simulation and Performance Prediction
Authors: Oeth C. V. , Hill A. D. , Zhu D. 
Published: February 2013

Abstract
A fully 3D modeling tool to evaluate and predict acid fracture performance across the wide range of carbonate field properties has been developed. The model simulates acid transport and fracture face dissolution. The acid transport model includes the non-Newtonian characteristics of most acid fracturing fluids, the solution of the 3D velocity and pressure fields, and diffusion of acid toward the fracture surface. The acid reaction algorithm permits live acid to leakoff and react within the rock matrix, forming wormholes that update the leakoff boundary condition for each time step. The acid fracture model utilizes commercial 3D fracture propagation software to define the physical domain of the acid fracture simulation.
The performance of an acid fracturing treatment is quantified with conductivity, which is strongly dependent on the etched width created by the acid. The model numerically solves equations describing 3D acid transport and reaction within a fracture to yield the etched width created by acid along the fracture. This conductivity is calculated with the simulator derived acid-etched width, using correlations recently developed that reflect the small scale heterogeneity of carbonate rock as it creates etching along the fracture surface. A case is presented typical of industry practice that demonstrates the model capabilities.
Theoretical and Numerical Simulation of Herschel-Bulkley Fluid Flow in Propped Fractures
Authors: Ouyang L. , Zhu D. , Hill A. D. 
Published: February 2013

Abstract
The flow of non-Newtonian fluids in porous media is important in many applications, such as polymer processing, heavy oil flow, and gel cleanup in propped fractures. Residual polymer gel in propped fractures results in low fracture conductivity and short effective fracture length, sometimes causing severe productivity impairment of a hydraulically fractured well. But non-Newtonian fluid flow behavior in porous media is difficult to be described and modeled. The Kozeny-Carman equation, a traditional permeability-porosity relationship, has been popularly used in porous media flow models. However, this relationship is not suitable for non-Newtonian fluid flow in porous media.
The aim of this work is to use a combination of 3D finite volume simulation and analytical calculations to develop a comprehensive model of Herschel-Bulkley non-Newtonian fluid flow through porous media. We present the mathematical model development, and then modify the model based on numerical simulation results. In the simulations, we developed a micro pore-scale model to mimic the real porous structure. The correlation of pressure gradient and superficial velocity was investigated under the influence of primary parameters, such as yield stress, power law index, consistency index, and proppant diameter. The Herschel-Bulkley model was used with an appropriate modification proposed by Papanastasiou to avoid the discontinuity of the apparent viscosity and numerical difficulties.
The result of the new model indicates that yield stress has a significant impact on non-Newtonian fluid flow through porous media. The analytical expression reveals the physical principles for flow velocity in porous media, and the variation trends of the threshold pressure gradient versus different influence factors are shown. By Computational Fluid Dynamics (CFD), we obtained a detailed view of streamlines, the velocity field, and the pressure distribution in porous media. Numerical calculation results show that, in the center of the throats of porous media, the increasing yield stress widens the central plug -like flow region, and the increasing power law index sharpens the velocity profile. The new model can be readily applied to provide a clear guide to selection of fracture fluid, and can be easily incorporated into any existing reservoir simulators.
Evaluation of Two Horizontal Wells in the Eagle Ford Using Oil-Based Chemical Tracer Technology to Optimize Stimulation Design
Authors: Spencer J. , Bucior D. , Catlett R. , Lolon E. 
Published: February 2013

Abstract
Horizontal well positioning through a target formation can have a significant impact on overall productivity from an unconventional oil well. This paper will discuss the evaluation of two horizontal wells completed in the oil section of the Eagle Ford Shale. These wells were completed using similar completion designs (hybrid frac design) with the method and number of frac stages determined by the geology, petrophysical, or geomechanical data.
The paper will describe how conventional analysis technologies including completion, flowback, and production data were compared to the relative oil flow from each stage measured using a recently developed hydrocarbon tracer technology to provide critical information on optimal well path design for use during future well development.
The stage production data provided by the use of the hydrocarbon tracers allows engineers to modify and improve their completion and stimulation programs. This paper will highlight tracer response interpretations of the two wells presented and the current status of the hydrocarbon-based tracer technology for hydraulic fracturing applications.
Comparison of Various Deterministic Forecasting Techniques in Shale Gas Reservoirs
Authors: Joshi Krunal , Lee John 
Published: February 2013

Abstract
There is a huge demand in the industry to forecast production in shale gas reservoirs accurately. There are many production estimation methods including several variations of decline curve analysis (DCA), analytical simulation, and numerical simulation. Each one of these methods has its advantages and disadvantages, but only the DCA techniques can use readily available production data to forecast rapidly and, to some extent, accurately.
Traditional DCA methods in use in the industry, particularly Arps’ decline model, were originally been developed for wells in boundary Dominated Flow (BDF). By contrast, in shale reservoirs, the dominant flow regime is long-duration transient flow. Therefore, the petroleum industry needed to develop newer models to match data in transient flow regimes and then for forecast production using these transient flow models, followed, in necessary, by BDF models. The Stretched Exponential model, the Duong model and the Arps model with a minimum terminal decline rate all have the ability to match and forecast wells with transient flow followed by BDF.
In this paper we propose revisions to the Duong model, to provide better fits to data in BDF regimes. A thorough analysis of actual well production and analytical simulation results were performed on selected wells in gas shales to compare the various DCA models to ascertain the model that provides the lowest discrepancy in estimates of remaining reserves. Individual well and grouped well analyses were performed to check the efficacy of the various models. We concluded that, in most cases, the newer decline models, such as the Duong method and its modifications, provide more accurate estimates of reserves for individual and grouped data sets than the Arps decline methods.
The outcome of this research should assist the industry to forecast gas production rapidly and more accurately in shale reservoirs. The grouped data methodology will enable us to forecast production in shale reservoirs even more rapidly. The grouped data approach will prove to be especially valuable when only limited data are available from wells with less than a few months of production history.
The Successful Results of Pławniowice Reservoir (Upper Silesia Region – South of Poland) Restoration by Hypolimnetic Withdrawal
Authors: Kostecki Maciej , Suschka Jan 
Published: February 2013

Abstract
The inter-reservoir enrichment phenomenon was exploited to curtail the reservoir eutrophication process. The Plawnowice reservoir (South Poland - Upper Silesia Region) has an area of 225 ha, volume of 29 mln m3, and a depth of 15 meters. According to the monitoring results in the years 1993-1998 the reservoir was qualified as hypereutrophic. Beginning in December 2003 a bottom pipe for hypolimnetic withdrawal was installed. In the period 2004-2010 a negative phosphorous balance was achieved. The discharge load of total phosphorous was in the beginning twice as high as the inflowing. During the first eight years with an inflow of 75 Mg P, the removed load of total phosphorus was 103 Mg P. In effect the net balance was 28 Mg P. The load, in respect to the surface area, of 2.2 to 3.3 gP/m2 per year, was reduced to a negative load of - 0.48 to - 3.3 gP/m2. The hypolimnetic maximum concentration of orthophosphates equal to 1.254 mg P-PO4/dm3 in 2004, was reduced to 0.236 mg P-PO4/dm3 in 2011. The respective factors and rate of eutrophication curtailing, including changes of phosphorus compounds have been discussed. Also changes of pH and visibility of the Secchi disc are presented. It was concluded that the presented method of hypolimnetic withdrawal is a lasting and effective process
Genotyping of GATA4 Gene Variant (G296S) in Malaysian Congenital Heart Disease Subjects by Real-Time PCR High Resolution Melting Analysis
Authors: Fawzi Nora , Vasudevan Ramachandran , Ismail Patimah , Alwi Mazeni , Fazli Abdul Aziz Ahmad , Almeamar Hussein , Afiqa Mohamad Nur , Etemad Ali 
Published: February 2013

Summary
Background: Congenital heart disease (CHD) is the most common birth defect; however, the underlying etiology is unrecognized in the majority of cases. GATA-binding protein 4 (GATA4), a cardiac transcription factor gene, has a crucial role in the cardiogenesis process; hence, a number of heterozygote sequence variations were identified as a cause of CHD. G296S heterozygote variant is the most frequently reported GATA4 gene sequence alteration. This study aims to investigate the role of G296S variant of the GATA4 gene in Malaysian CHD subjects.
Methods: We have investigated 86 Malaysian CHD subjects with cardiac septation defects for the presence of the GATA4 gene heterozygote variant (G296S) by the new technology of high resolution melting (HRM) analysis.
Results: Genotyping of G296S (c.886G>A) by HRM analysis shows that all the sample genotypes were of the wild GG type genotype and the heterozygote mutant GA genotype was totally absent from this study cohort.
Conclusions: The results of our study showed that the G296S variant of the GATA4 gene was not associated with the development of CHD in Malaysian subjects. The use of HRM analysis proved a cost-effective, high-throughput, specific and sensitive genotyping technique which eliminates the need for unnecessary sequencing.
Models of Development and Management of Brazilian University Sports: An Interpretation according to its Relationship with the State
Authors: Starepravo Fernando Augusto , Souza Juliano de , Marchi Júnior Wanderley 
Published: February 2013

Abstract The present study is intended to discuss the way in which the state is constituted as a major element for the management of Brazilian university teams, pointing out, above all, the most recent moment that represents a hybrid model of development. To do so, empirical resources of research has been used: 1. Documents that belong to the file of the FPDU (an institution in the state of Paraná which is in charge of university teams), 2. The existing legislation on the theme, 3. Interviews with some of the agents who took part in the FPDU as members of the directory board throughout its history. It has been concluded that the state is directly responsible for the development of university sports in Brazil, mainly because between them there is an inter-dependence relationship through the financial support of sports.