bluuebunny/crossref_metadata_2025_split huggingface dataset:
FGF Signaling Regulates Development of the Anterior Fontanelle
Authors: Bobzin Lauren , Nickle Audrey , Ko Sebastian , Ince Michaela , Bhojwani Arshia , Merrill Amy E. 
Published: July 2024

AbstractThe calvarial bones of the infant skull are connected by transient fibrous joints known as sutures and fontanelles, which are essential for reshaping during birth and postnatal growth. Genetic disorders such as Apert, Pfeiffer, Crouzon, and Bent bone dysplasia linked toFGFR2variants often exhibit multi-suture craniosynostosis and a persistently open anterior fontanelle (AF). This study leverages mouse genetics and single-cell transcriptomics to determine howFgfr2regulates closure of the AF closure and its transformation into the frontal suture during postnatal development. We find that cells of the AF, marked by the tendon/ligament factor SCX, are spatially restricted to ecto- or endocranial domains and undergo regionally selective differentiation into ligament, bone, and cartilage. Differentiation of SCX+ AF cells is dependent on FGFR2 signaling in cells of the osteogenic fronts which, when fueled by FGF18 from the ectocranial mesenchyme, express the secreted WNT inhibitor WIF1 to regulate WNT signaling in neighboring AF cells. Upon loss ofFgfr2,Wif1expression is lost, and cells of the AF retain a connective tissue-like fate failing to form the posterior frontal suture. This study provides new insights into regional differences in suture development by identifying an FGF-WNT signaling circuit within the AF that links frontal bone advancement with suture joint formation.
Social Status as a Latent Variable in the Amygdala of Observers of Social Interactions
Authors: Lee SeungHyun , Rutishauser Ueli , Gothard Katalin M. 
Published: July 2024

SummarySuccessful integration into a hierarchical social group requires knowledge of the status of each individual and of the rules that govern social interactions within the group. In species that lack morphological indicators of status, social status can be inferred by observing the signals exchanged between individuals. We simulated social interactions between macaques by juxtaposing videos of aggressive and appeasing displays where two individuals appeared in each other’s line of sight and their displays were timed to suggest the reciprocation of dominant and subordinate signals. Viewers of these videos successfully inferred the social status of the interacting characters. Dominant individuals attracted more social attention from viewers even when they were not engaged in social displays. Neurons in the viewers’ amygdala signaled the status of both the attended (fixated) and the unattended individuals suggesting that in third party observers of social interactions, the amygdala signals jointly the status of interacting parties.HighlightsMonkeys infer the social status of conspecifics from videos of simulated dyadic interactionsDuring fixations neural populations signal the social status of the attended individualsNeurons in the amygdala jointly encode the status of interacting individualsIn briefThird party-viewers of pairwise dominant-subordinate interactions infer social status from the observed behaviors. Neurons in the amygdala are tuned to the inferred dominant/subordinate status of both individuals.
Cell volume tunes macrophage innate inflammatory responses through promoting type I interferon signalling
Authors: Cook James R , Gleeson Tara A. , Allan Stuart M. , Lawrence Catherine B. , Brough David , Green Jack P. 
Published: July 2024

AbstractMacrophages are key effectors in co-ordinating inflammatory and immune responses to threats to the host. How macrophages decipher diverse danger signals to tailor inflammatory responses remains an unanswered question. Cell volume control is critical for normal cellular function. Disturbances in extracellular and intracellular homeostasis induce changes in cell volume, but the impact of disruptions in cell volume in controlling macrophage inflammatory responses is poorly understood. Here, we discover that macrophages use cell volume control as a bona fide danger sensing mechanism to promote and augment inflammatory responses. Using macrophages deficient in the volume regulated anion channel (VRAC), which lack cell volume control under hypo-osmotic conditions, we show that disruptions in cell volume are sensed by macrophages to drive a large transcriptomic response and induction of inflammation. Cell volume disruption, particularly loss of cell volume control, induces type I interferon signalling through a DNA– and STING-dependent mechanism, but independent of cGAS and 2’3’cGAMP transport. Further, we found that cell volume changes synergise with diverse pathogen-mediated signalling to augment type I interferon responses and exacerbate the cytokine storm in a mouse model of hyperinflammation. Our findings highlight cell volume as an important regulator in shaping inflammatory responses, adding to our understanding of how macrophages sense complex danger signals and threats.
Problem solving strategies used in mathematics textbooks for Turkish middle schools
Authors: Türkmen Dural Seda , Dede Yüksel 
Published: July 2024

PurposeThis study investigated the problem-solving strategies used in solving problems in the learning domain of numbers and operations in mathematics textbooks for Turkish middle schools.Design/methodology/approachTo this end, four middle school mathematics textbooks published by the Ministry of National Education of Turkey (MEB in Turkish), one from each grade level (Grades 5–8), were examined. The data in this document analysis study were analyzed using semantic content analysis.FindingsThe findings revealed that mathematics textbooks' most used problem-solving strategies for each level were drawing a figure (diagram), writing equality and inequality, making a table and making a systematic list. Drawing a diagram (figure) strategy was the most used strategy at each grade level, while working backwards was the least used one. Another finding was that finding a pattern and solving a simpler analogous problem strategies were rarely used at each grade level.Research limitations/implicationsThis study points out how problem-solving strategies used Grades 5-8 mathematics textbooks in a different culture like Türkiye. So, it may also give some important clues for applying problem-solving strategies in mathematics classrooms in a different culture.Practical implicationsThis study may draw the attention of educational stakeholders and textbook authors who want to understand and implement problem-solving strategies in mathematics classrooms by considering a different cultural perspective.Social implicationsThis study may point to the importance of using problem-solving strategies in mathematics and daily and social learning environments due to the nature of mathematical problem-solving and problem-solving strategies.Originality/valueThis document review study examined the problem-solving strategies used in Turkish middle school mathematics textbooks, and the data were analyzed using semantic content analysis. The findings revealed that mathematics textbooks' most used problem solving strategies for each level were drawing a figure (diagram), writing equality and inequality, making a table and making a systematic list. Drawing a diagram (figure) strategy was the most used strategy at each grade level, while working backwards was the least used one. Another finding was that finding a pattern and solving a simpler analogous problem strategies were rarely used at each grade level.
Quality improvement development in Swedish healthcare and welfare services
Authors: Andersson Ann-Christine 
Published: July 2024

Purpose
Quality improvement has developed and spread, and today, all Swedish Regions emphasize that their strategies are based on systematic improvement. This paper aims to describe and illuminate the development of Quality Improvement (QI) in Swedish healthcare and welfare organizations by using publications in a Swedish context.

Design/methodology/approach
The overview synthesis is inspired by a scoping literature review approach of relevant literature. All publications relevant to Swedish healthcare and welfare settings between 1992 until 2020 were included.

Findings
In all, 213 papers, 29 books and chapters and 34 dissertations related to QI and research in Swedish healthcare and welfare context were identified. From 2011 to 2020, the publication rate increased rapidly. Six different focus areas emerged: systematic and value-creating improvement work; collaboration between organizations and healthcare providers; use of improvement methods and (theoretical) models; leadership and learning; measurements, quality registers and follow-up; and involvement and patient safety. Further QI development in Swedish healthcare and welfare points to an increased importance of collaboration between organizations and coproduction with beneficiaries for the healthcare and welfare services.

Originality/value
This paper is one of the first to describe and illuminate the QI development in the healthcare and welfare sector in a country. The trajectory also points to a need for coproduction to handle future challenges.
The effect of foreign direct investment on economic growth in Afghanistan: an empirical insight
Authors: Mohd Thas Thaker Mohamed Asmy , Baryal Baryalai , Taghizadeh-Hesary Farhad 
Published: July 2024

PurposeThis paper examines the impact of foreign direct investment (FDI) on the economic growth of Afghanistan over the period 1990 to 2019.Design/methodology/approachThis study uses an autoregressive distributed lag (ARDL) to measure FDI’s impact on economic growth and determine the short- vs long-run relationship.FindingsThe results show that the F-bound cointegration test confirms the long-run relationship among the variables. The long-run and short-run results reveal that foreign direct investment has a significant negative impact on economic growth in the long run. However, domestic investment and labour force have a significant and positive impact on economic growth in the long run. Moreover, the impact of trade openness on economic growth is insignificant in the long run, while it has a significant negative impact in the short run.Originality/valueIn this study, we contribute to this research area by analysing the function of FDI in economic growth from Afghanistan’s experience and perspectives. This is the first study empirically examining this relationship in Afghanistan while considering other selected macroeconomic indicators. This paper could greatly benefit policymakers in Afghanistan by guiding the formulation of FDI policies that would spur its economic growth and development.
Financial performance and carbon emission disclosure
Authors: Al-Mari Jawaher R. , Mardini Ghassan H. 
Published: July 2024

PurposeThis study aims to investigate the impact of financial performance on carbon emission disclosure.Design/methodology/approachThe study uses ordinary least squares (OLS) multiple regression analysis on a sample of 177 Financial Times Stock Exchange 350 index (FTSE-350) non-financial firms to test the impact of market (Tobin’s Q) and accounting (return on equity) financial performance indicators on carbon emission disclosure.FindingsThe results show that the financial performance market indicator has a significant positive impact on carbon emission disclosure. The accounting indicator illustrates similar results except for Scope 3, where the results are insignificant. This study may help firms understand how financial performance affects carbon emission disclosure, particularly by showing that high-performing firms are motivated to maintain strong environmental practices and enhance carbon emission awareness.Originality/valueThis paper enhances stakeholders’ understanding of how firms’ environmental policies align with their financial objectives, thereby expanding knowledge in carbon accounting.
“Let’s catch up at Shivaji Park”: emotively conversing on connecting and un/belonging through a public space
Authors: Lahiri-Roy Reshmi , Roy Achinto , Karnik Rahul , Likhite Sandesh 
Published: July 2024

PurposeThis paper is based on the personal connections of the four authors to Shivaji Park, the largest public space in Mumbai. Three of the authors are childhood friends and were once long-term residents of that area. The focus of this article is Shivaji Park, anecdotally the largest park in the island city of Mumbai, with its historical connotations and its ongoing role as a relational and cultural artefact in the lives of these authors. The ongoing member status of all four authors in connection with the public space is explored despite all of them now ceasing to be locals.Design/methodology/approachThis article uses a qualitative approach utilising informal conversations between the four authors recorded on zoom as the research method. Supported by belonging and emotional reflexivity as conceptual frames, it investigates how the spatial context fosters a binding relationality, which is ongoing despite the now disparate locations of the authors.FindingsBased on a critical analysis of the recorded conversations between the authors the findings highlight that belonging/unbelonging centres around emotionally tinged representations of place.Originality/valueThe core of this paper rests in the emotional connections between the authors based on their collective memories with a public space and its surrounding areas as a focus. The use of informal conversations is crucial in teasing out nuanced aspects of data collected based on human relationalities. The paper emphasises the repercussions of ongoing changes stemming from urban progress. They incur emotional and human costs through a “culling” of connections and belongings.
A novel treatment approach using vitamin B12‐conjugated sericin for mitigating nanodiamond‐induced toxicity in darkling beetles
Authors: Saad Marwa , Selim Nabila , El‐Samad Lamia M. 
Published: July 2024

AbstractThe escalating use of nanodiamonds (NDs) has raised concerns about their ecotoxicological impact, prompting exploration of therapeutic interventions. This paper pioneers the examination of Vitamin B12‐conjugated sericin (VB12‐SER) as a potential therapeutic approach against ND‐induced toxicity in darkling beetles (Blaps polychresta). The study analyzes mortality rates and organ‐specific effects, covering the testis, ovary, and midgut, before and after treatments. Following exposure to 10 mg NDs/g body weight, within a subgroup of individuals termed ND2 with a mortality rate below 50%, two therapeutic treatments were administered, including pure sericin (SER) at 10 mg/mL and VB12‐SER at 10.12 mg/mL. Consequently, five experimental groups (control, SER, ND2, ND2+SER, ND2+SER+VB12) were considered. Kaplan–Meier survival analysis was performed to assess the lifespan distribution of the insects in these groups over a 30‐d period. Analyses revealed increased mortality and significant abnormalities induced by NDs within the examined organs, including cell death, DNA damage, enzyme dysregulation, antioxidant imbalances, protein depletion, lipid peroxidation, and morphological deformities. In contrast, the proposed treatments, especially (ND2+SER+VB12), demonstrated remarkable recovery, highlighting VB12‐conjugated SER's potential in mitigating ND‐triggered adverse effects. Molecular docking simulations affirmed binding stability and favorable interactions of the VB12‐SER complex with target proteins. This research enhances understanding of NDs’ effects on B. polychresta, proposing it as an effective bioindicator, and introduces VB12‐conjugated SER as a promising therapeutic strategy in nanotoxicological studies.
Universal screening for Lynch syndrome in endometrial cancer diagnoses in Auckland, New Zealand: The initial experience
Authors: Naiqiso Silipa Lock Sam , Moses Jo , Tan Ai Ling , Eva Lois 
Published: July 2024

BackgroundUniversal mismatch repair immunohistochemistry (MMR IHC) tumour testing in endometrial cancer (EC) for Lynch syndrome (LS) was introduced in Auckland, New Zealand, in January 2017. Identifying patients with LS allows them and their families to access risk reduction strategies. Universal MMR IHC testing aids in the molecular classification of EC and has prognostic and therapeutic implications.AimWe aimed to determine the incidence of LS in women with EC in Auckland, New Zealand, following the introduction of MMR testing and the impact of universal screening on local genetic services.Materials and methodsThis is a retrospective clinicopathological evaluation of women with a new EC diagnosis referred to the Auckland Gynaecological Oncology Unit from 1/1/17 to 31/12/18. Patient data were extracted from the Gynaecological Oncology Unit database and electronic records, and analysed using descriptive statistics.ResultsDuring the study period, 409 patients were diagnosed with EC, with an over‐representation of Pacific Islanders (32.5%). Of these, 82.6% underwent MMR IHC testing, 20% were MMR‐deficient (MMRd), and 71% had somatic hypermethylation. The Pacific Islander population had a 64% (odds ratio 0.36, P = 0.005) reduction in the odds of having MMRd tumours compared with Europeans. Of the patients who underwent MMR IHC testing, 5.5% were referred to a genetic clinic for germline testing. LS was confirmed in eight patients (2.3%).ConclusionLS was diagnosed in 2.3% of patients. There was an over‐representation of Pacific Islanders in the EC group but not among those diagnosed with LS.
A hyaluronic acid‐containing reagent compatible with glass‐bottom dishes and capable of sustained binding of human spermatozoa
Authors: Inoue Taketo , Iwayama Hiroshi , Uemura Mikiko , Taguchi Sayumi , Yamashita Yoshiki 
Published: July 2024

AbstractObjectiveCommercial products currently available for sperm selection utilizing hyaluronic acid (HA) binding prior to intracytoplasmic sperm injection (ICSI) are widely used but have some disadvantages. To potentially circumvent these limitations, we compared ICSI using a self‐made hyaluronic acid (smHA) reagent with ICSI using SpermSlow.MethodsThe binding of the reagents to spermatozoa on plastic‐ or glass‐bottom dishes was quantitated using spermatozoa that were isolated by density‐gradient centrifugation and swim‐up procedures (N = 10/group). Additionally, we investigated the relationship between the HA reagent used prior to ICSI and clinical outcomes after assisted reproduction with HA‐ICSI (N = 81).ResultsThe smHA reagent exhibited extremely stable binding to human spermatozoa. The binding time of spermatozoa was significantly longer in the smHA reagent than in SpermSlow on both plastic and glass dishes (plastic: 60.0 ± 0.0 min vs. 2.7 ± 5.9 min, P < 0.001; glass: 60.0 ± 0.0 min vs. 2.5 ± 1.8 min, P < 0.001). There were no significant differences in the normal fertilization rate between HA‐ICSI with the smHA reagent (128/160, 80.0%) and HA‐ICSI with SpermSlow (171/231, 74.0%, P = 0.184). The frequency of the blastocyst development from the HA‐ICSI‐derived zygote was significantly higher with the smHA reagent (74/101, 73.3%) than with SpermSlow (76/131, 58.0%, P = 0.019). The rates of biochemical pregnancy, clinical pregnancy, fetal heart movement, live birth, and miscarriage were not significantly different between HA‐ICSI with the smHA reagent and HA‐ICSI with SpermSlow.ConclusionsThe blastulation rate was higher for HA‐ICSI with the smHA reagent as compared with SpermSlow. Clinical outcomes, excluding blastulation, after HA‐ICSI were the same using smHA reagent and using SpermSlow. Spermatozoa binding to the smHA reagent was not attenuated over a 60‐min time course. In conclusion, this reagent may shorten and simplify HA‐ICSI procedures because smHA can be used with any dish material, making it easier to observe the spindle or assess intracytoplasmic morphology.
Consensus statement: support for supervisors of surgical training in Australia and Aotearoa New Zealand
Authors: Paltridge Deborah , Martin Jenepher , Churchill James , Grills Richard , Loveday Benjamin , Gupta Romi Das , Rennie Sarah Catherine 
Published: July 2024

AbstractThe Supervisor Support Consensus Statement has been developed after consultation with supervisors of surgical training for the Royal Australasian College of Surgeons (RACS) programmes in Australia and Aotearoa New Zealand and other key stakeholders. Six key areas have been recognized with specific recommendations crafted to improve the support and recognition of Supervisors: 1. Clarity of role, 2. Education and Training, 3. Local support, 4. RACS support, 5. Recognition and valuing of the Supervisor role, 6. Risk Management. The purpose of this consensus statement is to clearly articulate supervisor opinions on the support they require to undertake this important role. It has been produced by an independent writing group of experienced surgical supervisors and educators, with support from RACS education department. The consensus statement is a response to a needs assessment of supervisors of surgical training. The statements in this consensus document have been generated from comments and feedback from supervisors that have been refined through process of extensive consultation using a Delphi methodology. We advise specialty training Committees consider these statements and mandate them as part of their accreditation of terms. The role of the supervisor of training requires greater recognition, and incorporation in the Enterprise Bargaining Agreement (EBA) in Australia and the ASMS Te Whatu Ora SECA in Aotearoa New Zealand would ensure the provisions in this document are enacted. The six areas identified have transferability to other specialities and countries and are valuable when considering how to support supervisors involved in training our next generation of specialist doctors.
Association between human papillomavirus and preterm delivery: A systematic review and meta‐analysis
Authors: Kovács Dénes , Szabó Anett , Hegyi Péter , Ács Nándor , Keszthelyi Márton , Sára Levente , Csirzó Ádám , Mátrai Péter , Munnoch Krisztina , Nagy Rita , Bánhidy Ferenc 
Published: July 2024

AbstractIntroductionThe lifetime prevalence of human papillomavirus infection (HPV) is estimated to be around 80% and it is the most common sexually transmitted infection. Despite being well known for its oncologic relevance, it has been associated with adverse pregnancy outcomes, though available evidence is contradicting. Previous meta‐analyses involved articles which based HPV infection on Pap smear results, leading to a significant source of bias. Therefore, we aimed to assess the burden of genetically proven HPV infection on adverse pregnancy outcomes.Material and MethodsIn our meta‐analysis, pregnant women tested for HPV DNA were only considered eligible. We conducted a systematic search in three major databases (PubMed, Embase, and CENTRAL) on September 22, 2023. Cohort, cross‐sectional, and case‐control studies were eligible for the analysis. The exposed group consisted of HPV‐infected patients. We assessed the odds ratios (OR) with a confidence interval (CI) of 95%. In order to reduce the heterogeneity, we performed subgroup analyses based on different strains (high risk HPV, HPV 16/18, study design). The study was prospectively registered on PROSPERO (CRD42022370228).ResultsOur study involved 14 articles with 7008 women. A significant association was found between preterm delivery and HPV infection (OR: 1.94, CI: 1.31–2.87). No significant association was found when separately examining high‐risk HPV‐infected women (OR: 1.94, CI: 0.82–4.59), and HPV 16 or 18‐infected women (OR: 2.08, CI: 0.50–8.63) in terms of preterm delivery. No significant association was found between spontaneous abortion and HPV infection (OR: 1.02, CI: 0.16–6.31).ConclusionsOur analysis indicates an association between HPV infection and preterm delivery. It is imperative that future studies consider confounding variables more comprehensively. Additionally, the global implementation of HPV vaccination programs holds significance not only in oncology but also in obstetrics.