bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recruitment of neutrophils in glomeruli in early mouse sepsis is associated with E-selectin expression and activation of endothelial nuclear factor kappa-light-chain-enhancer of activated B cells and mitogen-activated protein kinase pathways
Authors: Wang Zhendong , Dayang Erna-Zulaikha , Zwiers Peter J , Hernandez Garcia Martha L , Luxen Matthijs , van Meurs Matijs , Kamps Jan A A M , Moser Jill , Molema Grietje 
Published: July 2024

Abstract
Sepsis is a dysregulated systemic inflammatory response to an infection, which can lead to multiple organ dysfunction syndrome that includes the kidney. Leukocyte recruitment is an important process of the host immune defense in response to sepsis. Endothelial cells (EC) actively regulate leukocyte recruitment by expressing adhesion molecules following the activation of dedicated intracellular signal transduction pathways. Previous studies reported that the expression of adhesion molecules was associated with the activation of endothelial nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65 and mitogen-activated protein kinase (MAPK) c-Jun pathways in vitro in response to conditions that mimic processes that occur in inflammation. This study aimed to investigate the spatiotemporal patterns of leukocyte recruitment, expression of adhesion molecules, and endothelial nuclear p65 and c-Jun localization in renal microvascular beds of septic mice. Here, we used a cecal ligation and puncture (CLP) sepsis mouse model and RT-qPCR and immunohistochemical staining. We showed that neutrophils, macrophages, and T lymphocytes were all present in the kidney, yet only neutrophils accumulated in a spatiotemporally discernible pattern, mainly in glomeruli at 4 h after CLP sepsis initiation. E-selectin, not vascular cell adhesion molecule-1 (VCAM-1), was expressed in glomeruli at the same time point. In a subset of mice at 72 h after CLP sepsis started, VCAM-1 expression was prominent in glomerular EC, which was not related to changes in mmu-microRNA(miR)-126a-3p levels, a short noncoding microRNA previously shown to inhibit the translation of VCAM-1 mRNA into protein. Nuclear localization of p65 and c-Jun occurred in EC of all microvascular segments at 4 and 7 h after CLP sepsis initiation. In summary, sepsis-induced recruitment of neutrophils, E-selectin expression, and NF-κB p65 and MAPK c-Jun pathway activation coincided in glomeruli at the early stage of the disease. In the other microvascular beds, sepsis led to NF-κB p65 and MAPK c-Jun pathway activation with limited expression of E-selectin and no association with VCAM-1 expression or leukocyte recruitment.
Combined immunogenicity evaluation for a new single-dose live-attenuated chikungunya vaccine
Authors: Buerger Vera , Maurer Gabriele , Kosulin Karin , Hochreiter Romana , Larcher-Senn Julian , Dubischar Katrin , Eder-Lingelbach Susanne 
Published: July 2024

Abstract

Background
Chikungunya is a serious and debilitating viral infection with a significant disease burden. VLA1553 (IXCHIQ®) is a live-attenuated vaccine licensed for active immunization for prevention of disease caused by chikungunya virus (CHIKV).

Methods
Immunogenicity following a single dose of VLA1553 was evaluated in healthy adults aged ≥18 years in two Phase 3 trials [N = 656 participants (per protocol analysis set)]. Immunogenicity data to 180 days post-vaccination [geometric mean titres (GMTs), seroresponse rate, seroconversion rate] were pooled for the two trials. A comparison of subgroups based on age, sex, body mass index (BMI), race and baseline seropositivity was included. All analyses were descriptive.

Results
Most participants were aged 18–64 years (N = 569/656 [86.7%]), there were slightly more females (N = 372/656 [56.7%]), most were not Hispanic/Latino (N = 579/656 [88.3%]), and most were White (N = 517/656 [78.8%]). In baseline seronegative participants, GMT peaked at Day 29 post-vaccination, and subsequently declined slightly but remained elevated until Day 180. At Days 29, 85 and 180, seroresponse rate was 98.3, 97.7 and 96.4% and seroconversion rate was 98.5, 98.4 and 98.2%. There were no differences in seroresponse rate in participants aged 18–64 years or ≥65 years at Day 29 (98.1 vs 100%), Day 85 (97.4 vs 100%) and Day 180 (96.3 vs 96.5%) nor based on sex, BMI, ethnicity or race. An immune response was shown in a small heterogenous population of baseline seropositive participants, with GMTs showing the same trend as baseline seronegative participants.

Conclusions
A single dose of VLA1553 elicited a very strong immune response by Day 29 that remained elevated at Day 180 in both baseline seronegative and seropositive participants in a combined evaluation of two Phase 3 trials. The vaccine was similarly immunogenic in participants aged ≥65 years and 18–64 years, and there were no differences based on subgroup analyses for sex, BMI, ethnicity or race.
New radiative and collisional atomic data for Sr ii and Y ii with application to Kilonova modelling
Authors: Mulholland L P , McElroy N E , McNeill F L , Sim S A , Ballance C P , Ramsbottom C A 
Published: July 2024

ABSTRACT
The spectra of singly ionized Strontium and Yttrium (Sr ii and Y ii) have been proposed as identifications of certain spectral features in the AT2017gfo spectrum. With the growing demand for non-local-thermodynamic-equilibrium (NLTE) simulations of Kilonovae, there is an increasing need for atomic data for these and other r-process elements. Our goal is to expand upon the current set of atomic data for r-process elements, by presenting transition probabilities and Maxwellian-averaged effective collision strengths for Sr ii and Y ii. The Breit–Pauli and darcR-matrix codes are employed to calculate the appropriate collision strengths, which are thermally averaged according to a Maxwellian distribution to calculate excitation and de-excitation rates. The tardis and ColRadPy packages are subsequently used to perform local thermodynamic equilibrium (LTE) and NLTE modelling, respectively. A complete set of transition probabilities and effective collision strengths involving levels for Sr ii and Y ii have been calculated for temperature ranges compatible with kilonova plasma conditions. Forbidden transitions were found to disagree heavily with the Axelrod approximation, an approximation which is currently employed by other models within the literature. Theoretically important spectral lines are identified with both LTE and NLTE modelling codes. LTE simulations in tardis reveal no new significant changes to the full synthetic spectra. NLTE simulations in ColRadPy provide indications of which features are expected to be strong for a range of regimes, and we include luminosity estimates. Synthetic emission spectra over kilonova densities and temperatures reveal potentially interesting spectral lines in the NIR.
[O iii] λ5007 emissions in extremely red quasars (ERQs) are compact
Authors: Lau Marie Wingyee , Perrotta Serena , Hamann Fred , Gillette Jarred , Rupke David S N , Vayner Andrey , Zakamska Nadia L , Wylezalek Dominika 
Published: July 2024

ABSTRACT
‘Extremely red quasars’ (ERQs) are a non-radio-selected, intrinsically luminous population of quasars at cosmic noon selected by their extremely red colour from rest-frame UV to mid-IR. ERQs are uniquely associated with exceptionally broad and blueshifted [O iii] $\lambda$5007 emission reaching speeds $\gt $6000 km s$^{-1}$. We obtained adaptive optics integral-field spectroscopic observations using Keck/OSIRIS and Gemini/NIFS of a sample of 10 ERQs with bolometric luminosities (10$^{47.0}$–10$^{47.9}$) erg s$^{-1}$ at $z\sim$ (2.3–3.0). The goal is to measure the sizes and spatially resolved kinematics of the [O iii]-emitting regions. We study the surface brightness maps and aperture-extracted spectra and model the point-spread functions. We identify signs of merger activities in the continuum emissions. We identify physically distinct [O iii] kinematic components that are bimodal and respectively trace ERQ-driven outflows of velocity dispersion $\gtrsim$250 km s$^{-1}$ and dynamically quiescent interstellar media. We find that the ERQ-driven ionized outflows are typically at $\sim$1 kpc scales whereas the quiescent ionized gas extend to a few kpc. Compared to normal quasars the extremely fast ERQ-driven [O iii] outflows tend to be more compact, supporting the notion that ERQs are in a young stage of quasar/galaxy evolution and represent unique physical conditions beyond orientation differences with normal quasar populations. The kinematically quiescent [O iii] emissions in ERQs tend to be spatially resolved but less extended than in normal quasars, which can be explained by global and patchy dust obscuration. The hint of ionization cones suggests some of the obscuration can be partially explained by a patchy torus.
Governance fix? Power and politics in controversies about governing generative AI
Authors: Ulnicane Inga 
Published: July 2024

Abstract
The launch of ChatGPT in late 2022 led to major controversies about the governance of generative artificial intelligence (AI). This article examines the first international governance and policy initiatives dedicated specifically to generative AI: the G7 Hiroshima process, the Organisation for Economic Cooperation and Development reports, and the UK AI Safety Summit. This analysis is informed by policy framing and governance literature, in particular by the work on technology governance and Responsible Innovation. Emerging governance of generative AI exhibits characteristics of polycentric governance, where multiple and overlapping centers of decision-making are in collaborative relationships. However, it is dominated by a limited number of developed countries. The governance of generative AI is mostly framed in terms of the risk management, largely neglecting issues of purpose and direction of innovation, and assigning rather limited roles to the public. We can see a “paradox of generative AI governance” emerging, namely, that while this technology is being widely used by the public, its governance is rather narrow. This article coins the term “governance fix” to capture this rather narrow and technocratic approach to governing generative AI. As an alternative, it suggests embracing the politics of polycentric governance and Responsible Innovation that highlight democratic and participatory co-shaping of technology for social benefit. In the context of the highly unequal distribution of power in generative AI characterized by a high concentration of power in a small number of large tech companies, the government has a special role in reshaping the power imbalances by enabling wide-ranging public participation in the governance of generative AI.
Simultaneous indoor radon/thoron and in situ outdoor gamma dose measurements and estimation of annual effective dose in a tin mining area of Jos Plateau, Nigeria
Authors: Waida Jasini , Oyeleke Oyebode A , Ademola Janet A 
Published: July 2024

Abstract
Radon, a radioactive gas can increase the risk of lung cancer when breathe in. Indoor Rn-222 and Rn-220 concentrations were determined using passive radon monitor in some dwellings in a Sn mining area of Jos Plateau. Outdoor gamma radiation was also measured with a hand-held survey meter. The range of Rn-222 and Rn-220 concentrations was from 7–53 Bq m−3 to 41–267 Bq m−3 with averages of 27 ± 17 and 92 ± 65 Bq m−3, respectively. The mean total effective dose due to Rn-222 + Rn-220 was estimated as 2.84 ± 1.57 mSv y−1. Rn-220 contributed between 50 and 95% to the total annual effective dose. There was no correlation between indoor Rn-220 and Rn-222 concentrations in the dwellings. Outdoor gamma radiation measured was between 0.31 ± 0.06 and 0.62 ± 0.08 μSv h−1, and mean annual effective dose calculated was 1.14 ± 0.21 mSv y−1. It is concluded from this study that thoron should not be neglected in dose assessment.
The Fundamental Role of Character Coding in Bayesian Morphological Phylogenetics
Authors: Khakurel Basanta , Grigsby Courtney , Tran Tyler D , Zariwala Juned , Höhna Sebastian , Wright April M 
Published: July 2024

Abstract
Phylogenetic trees establish a historical context for the study of organismal form and function. Most phylogenetic trees are estimated using a model of evolution. For molecular data, modeling evolution is often based on biochemical observations about changes between character states. For example, there are 4 nucleotides, and we can make assumptions about the probability of transitions between them. By contrast, for morphological characters, we may not know a priori how many characters states there are per character, as both extant sampling and the fossil record may be highly incomplete, which leads to an observer bias. For a given character, the state space may be larger than what has been observed in the sample of taxa collected by the researcher. In this case, how many evolutionary rates are needed to even describe transitions between morphological character states may not be clear, potentially leading to model misspecification. To explore the impact of this model misspecification, we simulated character data with varying numbers of character states per character. We then used the data to estimate phylogenetic trees using models of evolution with the correct number of character states and an incorrect number of character states. The results of this study indicate that this observer bias may lead to phylogenetic error, particularly in the branch lengths of trees. If the state space is wrongly assumed to be too large, then we underestimate the branch lengths, and the opposite occurs when the state space is wrongly assumed to be too small.
Towards accurate monitoring of water content in woody tissue across tropical forests and other biomes
Authors: Martius Lion R , Mencuccini Maurizio , Bittencourt Paulo R L , Moraes Alves Moisés , Binks Oliver , Sanchez-Martinez Pablo , da Costa Antonio C L , Meir Patrick 
Published: July 2024

Abstract
Forest ecosystems face increasing drought exposure due to climate change, necessitating accurate measurements of vegetation water content to assess drought stress and tree mortality risks. Although Frequency Domain Reflectometry offers a viable method for monitoring stem water content by measuring dielectric permittivity, challenges arise from uncertainties in sensor calibration linked to wood properties and species variability, impeding its wider usage. We sampled tropical forest trees and palms in eastern Amazônia to evaluate how sensor output differences are controlled by wood density, temperature and taxonomic identity. Three individuals per species were felled and cut into segments within a diverse dataset comprising five dicotyledonous tree and three monocotyledonous palm species on a wide range of wood densities. Water content was estimated gravimetrically for each segment using a temporally explicit wet-up/dry-down approach and the relationship with the dielectric permittivity was examined. Woody tissue density had no significant impact on the calibration, but species identity and temperature significantly affected sensor readings. The temperature artefact was quantitatively important at large temperature differences, which may have led to significant bias of daily and seasonal water content dynamics in previous studies. We established the first tropical tree and palm calibration equation which performed well for estimating water content. Notably, we demonstrated that the sensitivity remained consistent across species, enabling the creation of a simplified one-slope calibration for accurate, species-independent measurements of relative water content. Our one-slope calibration serves as a general, species-independent standard calibration for assessing relative water content in woody tissue, offering a valuable tool for quantifying drought responses and stress in trees and forest ecosystems.
Prophylactic Radiologic Interventions for Postpartum Hemorrhage Control in Women With Placenta Accreta Spectrum Disorder
Authors: Bonsen Lisanne R. , Sleijpen Kosma , Hendriks Joris , Urlings Thijs A.J. , Dekkers Olaf M. , le Cessie Saskia , van de Velde Marc , Gurung Pema , van den Akker Thomas , van der Bom Johanna G. , Henriquez Dacia D.C.A. 
Published: July 2024

OBJECTIVE:
To quantify the association between prophylactic radiologic interventions and perioperative blood loss during cesarean delivery in women with placenta accreta spectrum disorder through a systematic review and network meta-analysis.

DATA SOURCES:
On January 3, 2023, a literature search was conducted in PubMed, EMBASE, Cochrane Library, and Web of Science. We also checked ClinicalTrials.gov retrospectively. Prophylactic radiologic interventions to reduce bleeding during cesarean delivery involved preoperative placement of balloon catheters, distal (internal or common iliac arteries) or proximal (abdominal aorta), or sheaths (uterine arteries). The primary outcome was volume of blood loss; secondary outcomes were the number of red blood cell units transfused and adverse events. Studies including women who received an emergency cesarean delivery were excluded.

METHODS OF STUDY SELECTION:
Two authors independently screened citations for relevance, extracted data, and assessed the risk of bias of individual studies with the Cochrane Risk of Bias in Non-randomized Studies of Interventions tool.

TABULTATION, INTEGRATION, AND RESULTS:
From a total of 1,332 screened studies, 50 were included in the final analysis, comprising 5,962 women. These studies consisted of two randomized controlled trials and 48 observational studies. Thirty studies compared distal balloon occlusion with a control group, with a mean difference in blood loss of −406 mL (95% CI, −645 to −167). Fourteen studies compared proximal balloon occlusion with a control group, with a mean difference of −1,041 mL (95% CI, −1,371 to −710). Sensitivity analysis excluding studies with serious or critical risk of bias provided similar results. Five studies compared uterine artery embolization with a control group, all with serious or critical risk of bias; the mean difference was −936 mL (95% CI, −1,522 to −350). Reported information on adverse events was limited.

CONCLUSION:
Although the predominance of observational studies in the included literature warrants caution in interpreting the findings of this meta-analysis, our findings suggest that prophylactic placement of balloon catheters or sheaths before planned cesarean delivery in women with placenta accreta spectrum disorder may, in some cases, substantially reduce perioperative blood loss. Further study is required to quantify the efficacy according to various severities of placenta accreta spectrum disorder and the associated safety of these radiologic interventions.

SYSTEMATIC REVIEW REGISTRATION:
PROSPERO, CRD42022320922.
High-frequency Power Doppler Ultrasonography in Predicting Burn Depth: A Preliminary Case Report
Authors: Saijo Yusaku , Akaishi Satoshi , Kuwahara Hiroaki 
Published: July 2024

Summary:
Accurate burn depth assessment is essential to decide an appropriate surgical procedure. However, most cases of burn depth are diagnosed with subjective judgment by an experienced plastic surgeon. There is a need for a simple, noninvasive, and accurate diagnostic method. Here, the authors present two burn cases in which burn depth was predicted using high-frequency power Doppler ultrasonography. In case 1, the patient showed partial deep burn area prediagnosed by clinical inspection in dorsal area. However, pulsatile microcirculation was detected in the deep dermal layer using high-frequency power Doppler ultrasonography, and we rediagnosed it as deep dermal burn. Tangential excision was performed to debride necrotic tissue, preventing excessive removal of viable dermal tissue. In case 2, the patient showed anterior chest burn covered eschar. Pulsatile microcirculation was detected in the dermis using high-frequency power Doppler ultrasonography. The authors diagnosed the area as superficial dermal burn and opted for conservative treatment. Dermal microvascular damage is a more sensitive indicator of tissue injury. Hence, the burn depth can be assessed using dermal microcirculation. To the best of the authors’ knowledge, there are no reports on the evaluation of blood flow in burn wounds using high-frequency power Doppler ultrasonography. In this case report, the authors introduce the possibility of using high-frequency ultrasonography to assess burn depth.
Association between frailty and acute kidney injury after cardiac surgery: unraveling the moderation effect of body fat through an international, retrospective, multicohort study
Authors: Bai Yun-Xiao , Wang Zi-Hao , Lv Yong , Liu Jie , Xu Zhen-Zhen , Feng Yi-Qi , Liu Guo-Yang , Yin Ping , Wang Yan-Ting , Dong Nian-Guo , Wu Qing-Ping 
Published: July 2024

Background:
Acute kidney injury (AKI) is a common and serious complication after cardiac surgery that significantly affects patient outcomes. Given the limited treatment options available, identifying modifiable risk factors is critical. Frailty and obesity, two heterogeneous physiological states, have significant implications for identifying and preventing AKI. Our study investigated the interplay among frailty, body composition, and AKI risk after cardiac surgery to inform patient management strategies.

Material and methods:
This retrospective cohort study included three international cohorts. Primary analysis was conducted on adult patients who underwent cardiac surgery between 2014 and 2019 at Wuhan Union Hospital, China. We tested the generalizability of our findings with data from two independent international cohorts, the Medical Information Mart for Intensive Care IV (MIMIC-IV) and the eICU Collaborative Research Database. Frailty was assessed using a clinical lab-based frailty index (FI-LAB), while total body fat percentage (BF%) was calculated based on a formula accounting for BMI, sex, and age. Logistic regression models were used to analyze the associations between frailty, body fat, and AKI, adjusting for pertinent covariates.

Results:
A total of 8785 patients across three international cohorts were included in the study. In the primary analysis of 3569 patients from Wuhan Union Hospital, moderate and severe frailty were associated with an increased AKI risk after cardiac surgery. Moreover, a nonlinear relationship was observed between BF% and AKI risk. When stratified by the degree of frailty, lower body fat correlated with a decreased incidence of AKI. Extended analyses using the MIMIC-IV and eICU cohorts (n=3951 and n=1265, respectively) validated these findings and demonstrated that a lower total BF% was associated with decreased AKI incidence. Moderation analysis revealed that the effect of frailty on AKI risk was moderated by the BF%. Sensitivity analyses demonstrated results consistent with the main analyses.

Conclusion:
Higher degrees of frailty were associated with an elevated risk of AKI following cardiac surgery, and total BF% moderated this relationship. This research underscores the significance of integrating frailty and body fat assessments into routine cardiovascular care to identify high-risk patients for AKI and implement personalized interventions to improve patient outcomes.