bluuebunny/crossref_metadata_2025_split huggingface dataset:
The case of the neonate vs. LMIC medical academia—a jury-style systematic review of 32 years of literature without significant mortality reduction
Authors: Amadi Hippolite O. , Abioye Ifeoluwa O. , Ugbolue Ukadike C. , Ekpenyong Rhoda-Dara , Ekwem Nnamdi F. , Nwaneri Ogechi J. , Dike Chidiebere 
Published: July 2024

IntroductionThe high neonatal mortality rate in low- and middle-income countries (LMICs) such as Nigeria has lasted for more than 30 years to date with associated nursing fatigue. Despite prominent hard work, technological improvements, and many publications released from the country since 1990, the problem has persisted, perhaps due to a lack of intervention scale-up. Could there be neglected discoveries unwittingly abandoned by Nigerian policymakers over the years, perhaps locked up in previous publications? A careful review may reveal these insights to alert policymakers, inspire researchers, and refocus in-country research efforts towards impactful directions for improving neonatal survival rates. The focus was to determine the prevailed effectiveness of LMIC medical academia in creating solutions to end the high neonatal mortality rate.MethodsAn unconventional systematic review protocol structure following the PRISMA 2020 checklist was designed and registered at INPLASY (registration number: INPLASY202380096, doi: 10.37766/inplasy2023.8.0096). A jury of paediatricians was assembled and observed by a team of legal professionals. The jury searched the literature from 1990 to the end of 2022, extracted newborn-related articles about Nigeria, and assessed and debated them against expected criteria for solution creation, translation, scale-up, sustainability, and national coverage. Each juror used preset criteria to produce a verdict on the possibility of a published novel idea being a potential game-changer for improving the survival rate of Nigerian neonates.ResultsA summation of the results showed that 19 out of 4,286 publications were assessed to possess potential strategies or interventions to reduce neonatal mortality. Fourteen were fully developed but not appropriately scaled up across the country, hence denying neonates proper access to these interventions.ConclusionNigeria may already have the required game-changing ideas to strategically scale up across the nation to accelerate neonatal survival. Therefore, LMIC healthcare systems may have to look inward to strengthen what they already possess.Systematic Review Registrationhttps://inplasy.com/, identifier (INPLASY202380096).
Influence of fecal fermentation on the anthelmintic activity of proanthocyanidins and ellagitannins against human intestinal nematodes and Caenorhabditis elegans
Authors: Jato Jonathan , Orman Emmanuel , Boakye Yaw Duah , Belga François Ngnodandi , Ndjonka Dieudonné , Oppong Bekoe Emelia , Liebau Eva , Spiegler Verena , Hensel Andreas , Agyare Christian 
Published: July 2024

Some tannin-rich plants such as Combretum mucronatum and Phyllanthus urinaria are widely used in Africa for the control of parasitic nematodes in both humans and livestock. Tannins have been recognized as an alternative source of anthelmintic therapies, and hence, recent studies have focused on both the hydrolyzable and condensed tannins. These groups of compounds, however, have poor oral bioavailability and are metabolized by gut microbiota into lower molecular weight compounds. The role of these metabolites in the anthelmintic activities of tannins has not been explored yet. This study investigated the effects of fecal metabolism on the anthelmintic potential of procyanidin C1 (PC1) and geraniin and the tannin-enriched extracts of C. mucronatum (CML) and P. urinaria (PUH), which contain these compounds, respectively. Metabolites were formed by anaerobic fermentation of the test compounds and extracts in a fresh human fecal suspension for 0 h, 4 h, and 24 h. Lyophilized samples were tested in vitro against hookworm larvae and whipworm (Trichuris trichiura) larvae obtained from naturally infected human populations in Pru West District, Bono East Region, Ghana, and against the wildtype strain of Caenorhabditis elegans (L4). Both extracts and compounds in the undegraded state exhibited concentration-dependent inhibition of the three nematodes. Their activity, however, significantly decreased upon fecal metabolism. Without fermentation, the proanthocyanidin-rich CML extract was lethal against hookworm L3 (LC50 = 343.5 μg/mL, 95% confidence interval (CI) = 267.5–445.4), T. trichiura L1 (LC50 = 230.1 μg/mL, CI = 198.9–271.2), and C. elegans (LC50 = 1468.1 μg/mL, CI = 990.3–1946.5). PUH, from which the ellagitannin geraniin was isolated, exhibited anthelmintic effects in the unfermented form with LC50 of 300.8 μg/mL (CI = 245.1–374.8) against hookworm L3 and LC50 of 331.6 μg/mL (CI = 290.3–382.5) against T. trichiura L1, but it showed no significant activity against C. elegans L4 larvae at the tested concentrations. Similarly, both compounds, procyanidin C1 and geraniin, lost their activity when metabolized in fecal matter. The activity of geraniin at a concentration of 170 μg/mL against C. elegans significantly declined from 30.4% ± 1.8% to 14.5% ± 1.5% when metabolized for 4 h, whereas that of PC1 decreased from 32.4% ± 2.3% to 8.9% ± 0.9% with similar treatment. There was no significant difference between the anthelmintic actions of metabolites from the structurally different tannin groups. The outcome of this study revealed that the intact bulky structure of tannins (hydrolyzable or condensed) may be required for their anthelmintic action. The fermented products from the gut may not directly contribute toward the inhibition of the larvae of soil-transmitted helminths.
Examining the clinical validity of the global psychotrauma screen in refugees
Authors: Pinto Janaina V. , Hoeboer Christopher , Hunt Caroline , O’Toole Brian , Olff Miranda 
Published: July 2024

IntroductionThe Global Psychotrauma Screen (GPS) is a brief transdiagnostic screener that covers a broad range of trauma-related disorders as well as risk factors known to influence the course of symptoms.MethodsWe analyzed data from African war refugees in Australia (n = 70), including the GPS, the Structured Clinical Interview for DSM-5 Disorders (SCID-5), the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5), and the Brief Resilience Scale (BRS).ResultsUsing the Youden’s J Index to examine the clinical validity of the GPS subscales measuring PTSD, dissociation, depression, and generalized anxiety disorder (GAD), we found that a PTSD subscale score of 3 or higher, and a depression and dissociation subscale score of 1 or higher, was optimally efficient for detecting a probable diagnosis (Youden’s J = 0.76, J = 0.72, and J = 0.90, respectively) with high sensitivity and specificity. We were unable to test the GPS clinical validity for GAD due to the low GAD occurrence. The GPS resilience item was not related to the total score (r = 0.02), indicating low convergent validity for resilience. Risk factors, including current stressors and childhood trauma history, were related to more severe GPS symptom scores, while lack of resilience, social support, and history of mental illness were not.ConclusionWe conclude that the GPS may be a useful screening tool for PTSD, depression, and the dissociative subtype in refugees.
Uric acid mediates the relationship between mixed heavy metal exposure and renal function in older adult people
Authors: Pan Sai , Niu Yue , Duan Shuwei , Zhao Delong , Wang Qian , Dong Zheyi , Cai Guangyan , Chen Xiangmei 
Published: July 2024

BackgroundPopulation aging is a pivotal trend observed globally, and the exposure to heavy metals can exacerbate the aging process and lead to kidney damage. However, the impact of combined heavy metal exposure on renal function among older individuals remains elusive. Our study employs machine learning techniques to delve into the effects and underlying mechanisms of mixed exposure to heavy metals on the renal function of the aging population.MethodsThis study extracted comprehensive data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2015 and 2020. A total of 3,175 participants aged 60 years and above, with complete information on six metals – lead, cadmium, manganese, cobalt, mercury, and selenium, along with relevant covariates, were included in the study. To assess the impact of single or mixed metal exposure on the renal function of older adult individuals, various statistical techniques were employed: multiple logistic regression, weighted quantitative sum (WQS) regression, Bayesian kernel machine regression (BKMR), and mediation effects analysis.ResultsMultiple logistic regression revealed that selenium and manganese were protective factors for chronic kidney disease (CKD). Cobalt was a risk factor for CKD. High concentrations of lead, cadmium, and cobalt were risk factors for urinary albumin creatinine ratio (ACR). WQS analyses revealed that mixed metal exposure was positively correlated with estimated glomerular filtration rate (eGFR) but negatively correlated with CKD. Selenium and manganese can neutralize the effects of other metals on eGFR. Mixed metal exposure was positively correlated with ACR, with lead and cadmium having a substantial effect. Mediation analysis showed that uric acid (UA) had a mediating effect of 9.7% and −19.7% in the association between mixed metals exposure and proteinuria and CKD, respectively.ConclusionThe impact of heavy metals on renal function in the older adult differs from that of adolescents and adults. This study suggests that elevated levels of mixed metals exposure are linked to proteinuria and CKD, with UA serving as a mediating factor.
The distribution of Apis laboriosa revisited: range extensions, biogeographic affinities, and species distribution modelling
Authors: Otis Gard W. , Huang Man-Juan , Kitnya Nyaton , Sheikh Umer Ayyaz Aslam , Faiz Abu ul Hassan , Phung Chinh H. , Warrit Natapot , Peng Yan-Qiong , Zhou Xin , Oo Hlaing Min , Acharya Namoona , Devkota Kedar 
Published: July 2024

IntroductionApis laboriosa, the Himalayan giant honeybee, inhabits the foothills of Himalaya and neighboring mountainous regions. Here we revise its distribution in light of recent reports and discoveries, review the ecozones it inhabits, and reassess its likely distribution through species distribution modeling.MethodsWe revised the range map for A. laboriosa by mapping locality records from various sources: refereed research publications, museum specimens, records with identifiable images of bees in publicly available databases, personal observations of the authors, and photos/videos and their coordinates submitted to the authors by honey-hunters, beekeepers, and extension workers. We then used that map to determine the ecozones in which the species occurs. The geographical coordinates of the data localities were used to estimate the potential suitable areas for the bee with MaxEnt modeling.ResultsOur research filled in several previously identified gaps in the distribution of A. laboriosa: in western Nepal; mountainous regions of Myanmar, northwestern Thailand, and northern Laos; several river valleys in Xizang and Yunnan, China; and northeastern Pakistan. Over most of its range this bee species primarily occupies subtropical broadleaf forests with strong Himalayan affinities. However, in the western part of its range it extends into zones dominated by conifers. The sites where A. laboriosa has been recorded closely match the predicted range of the species. Two variables, mean temperature of the coldest quarter and temperature seasonality, contributed most (76%) to the species distribution model.DiscussionApis laboriosa has a more extensive distribution in the foothills of the Himalaya and neighboring mountainous regions than has been previously recognized. The range now extends from longitude 74.4°–105.9°E, a linear distance of 3300 km, and from latitude 19.2°N–34.8°N. We have documented nesting on tree branches in northern Vietnam. Future research is warranted on its elevational migrations along river valleys, population differentiation, and ecological role as a pollinator in the different ecological zones it inhabits.
In Vitro Evaluation of Probiotic Properties and Anti-Pathogenic Effects of Lactobacillus and Bifidobacterium Strains as Potential Probiotics
Authors: Lee Jaekoo , Jo Jaehyun , Wan Jungho , Seo Hanseul , Han Seung-Won , Shin Yoon-Jung , Kim Dong-Hyun 
Published: July 2024

Probiotics restore gut microbial balance, thereby providing health-promoting effects to the host. They have long been suggested for managing intestinal disorders caused by pathogens and for improving gut health. This study evaluated the probiotic properties and anti-pathogenic effects of specific probiotic strains against the intestinal pathogens Staphylococcus aureus and Escherichia coli. The tested strains—Lactiplantibacillus plantarum LC27, Limosilactobacillus reuteri NK33, Lacticaseibacillus rhamnosus NK210, Bifidobacterium longum NK46, and Bifidobacterium bifidum NK175—were able to survive harsh conditions simulating gastric and intestinal fluids. These strains exhibited good auto-aggregation abilities (41.8–92.3%) and ideal hydrophobicity (30.9–85.6% and 38.3–96.1% for xylene and chloroform, respectively), along with the ability to co-aggregate with S. aureus (40.6–68.2%) and E. coli (38.6–75.2%), indicating significant adhesion levels to Caco-2 cells. Furthermore, these strains’ cell-free supernatants (CFSs) demonstrated antimicrobial and antibiofilm activity against S. aureus and E. coli. Additionally, these strains inhibited gas production by E. coli through fermentative activity. These findings suggest that the strains tested in this study have potential as novel probiotics to enhance gut health.
Relationships within Bolbitis sinensis Species Complex Using RAD Sequencing
Authors: Nie Liyun , Fang Yuhan , Xia Zengqiang , Wei Xueying , Wu Zhiqiang , Yan Yuehong , Wang Faguo 
Published: July 2024

Species identification and phylogenetic relationship clarification are fundamental goals in species delimitation. However, these tasks pose challenges when based on morphologies, geographic distribution, and genomic data. Previously, two species of the fern genus Bolbitis, B. × multipinna and B. longiaurita were described based on morphological traits; they are phylogenetically intertwined with B. sinensis and fail to form monophyletic groups. To address the unclear phylogenetic relationships within the B. sinensis species complex, RAD sequencing was performed on 65 individuals from five populations. Our integrated analysis of phylogenetic trees, neighbor nets, and genetic structures indicate that the B. sinensis species complex should not be considered as separate species. Moreover, our findings reveal differences in the degree of genetic differentiation among the five populations, ranging from low to moderate, which might be influenced by geographical distance and gene flow. The Fst values also confirmed that genetic differentiation intensifies with increasing geographic distance. Collectively, this study clarifies the complex phylogenetic relationships within the B. sinensis species complex, elucidates the genetic diversity and differentiation across the studied populations, and offers valuable genetic insights that contribute to the broader study of evolutionary relationships and population genetics within the Bolbitis species.
International Perspectives in Education and Communication
Authors: Kefalaki Margarita , Diamantidaki Fotini 
Published: July 2024

Rapid technological development, the increasing need for sustainability standards and actions, combined with the constant rise of artificial intelligence (AI), impact all industries and workplaces, including the education sector (Tettamanzi et al., 2023). Our ‘new normal’, after the COVID-19 pandemic, precipitated educators to implement changes to their teaching in order to help them provide an effective educational learning experience (Tettamanzi et al., 2023), hence making it crucial to redefine our approaches, plan, innovate and readjust to all the novel needs. The four research papers of this issue discuss ways in which education professionals and beyond innovate and adapt to a ‘new normal’.
Eosinophilic Cellulitis (Wells Syndrome): A Case Report
Authors: Тихоновская И.В. , Лесничая О.В. , Катина М.А. , Захарова О.В. , Лапоревич В.Б. , Ловчиновская Ю.А. 
Published: July 2024

В статье представлен случай эозинофильного целлюлита (синдрома Уэллса) – редкого дерматоза с разнообразными клиническим проявлениями. В классическом варианте эозинофильный целлюлит напоминает бактериальный целлюлит, но может проявляться уртикариями, пятнами, везикулами, высыпаниями, напоминающими многоформную экссудативную эритему. Диагноз основывается на клинических проявлениях и данных гистологического исследования: наличие дермальных инфильтратов, состоящих из эозинофилов, гистиоцитов и «фигур пламени». Лечение включает топические и системные кортикостероиды, дапсон, интерферон-альфа, азатиоприн, гидроксихлорохин в сочетании с нестероидными противовоспалительными препаратами, тетрациклины, дупилумаб. Низкие дозы системных глюкокортикостероидов позволяют контролировать заболевание.
A case of eosinophilic cellulitis is presented in the article. Eosinophilic cellulitis (syn: Wells syndrome) is a rare dermatosis with a variety of clinical manifestations. In the classic version, it resembles bacterial cellulitis, but can manifests itself as urticaria, macules, vesicles, eruptions resembling erythema multiforme. The diagnosis is based on clinical and histological examination data: the presence of dermal infiltrates with eosinophils, histiocytes and "flame figures". Treatment includes topical and systemic corticosteroids, dapsone, interferon alpha, azathioprine, hydroxychloroquine in combination with nonsteroidal anti-inflammatory drugs, tetracyclines, dupilumab. Low doses of systemic glucocorticosteroids may control the disease.
SCIENTIFIC AND TECHNOLOGICAL PROGRESS AND ITS ECONOMIC EFFICIENCY
Authors: МАХНЕНКО С.И. , ХУДАЕВА А.С. 
Published: July 2024

В статье рассмотрено понятие научно-технического прогресса, влияние на эффективность экономики его показателей. Рассмотрены основные экономические показатели эффективности, влияющие на состояние научно-технического прогресса как на макро, так и микроуровне. Проанализированы затраты, возникающие при получении экономического эффекта от научно-технического прогресса, а также методика их анализа.
The article considers the concept of scientific and technological progress, the impact on the efficiency of the economy of its indicators. The main economic performance indicators affecting the state of scientific and technological progress at both the macro and micro levels are considered. The costs arising from obtaining an economic effect from scientific and technological progress, as well as the methodology of their analysis, are analyzed.
Improving the activities of enterprises in the construction industry in the context of the economic crisis
Authors: Пастухова Л.Р. 
Published: July 2024

В статье рассматриваются особенности государственных контрактов на выпол нение строительных, проектно-изыскательских и иных работ в строительной отрасли экономики. Государственный договор также устанавливает обязательное требование к порядку приемки работ, с тем чтобы соответствовать его объему и качеству условиям, предусмотренным в этом договоре, что способствует эффективному и своевременному исполнению государственных контрактов.
The article discusses the features of state contracts for the implementation of construction, design and survey and other works in the construction industry. The state contract also establishes a mandatory requirement for the procedure for acceptance of work in order to meet its volume and quality with the conditions provided for in this contract, which contributes to the effective and timely execution of state contracts.
Economic crisis 2020: causes and development forecasts
Authors: Зюзя Е.В. , Пыжикова Н.И. 
Published: July 2024

В статье рассмотрен исторический аспект экономических кризисов. На основе изу чения статистических материалов, прогнозов ВЭБа, Центробанка проведена аналитическая работа, результатом которой стал представленный анализ экономического кризиса 2020 - причины его воз никновения, его отличия от спадов экономики, которые были ранее в мировой экономической истории, а также возможные варианты и сценарии развития кризиса и выхода из него.
The article considers the historical aspect of economic crises. Based on the study of statistical materials, forecasts of VEB, the Central Bank, analytical work was carried out, the result of which was an analysis of the economic crisis of 2020 - the causes of its occurrence, its differences from economic downturns that were earlier in world economic history, as well as possible options and scenarios for the development of the crisis and exit from it.
Aircraft manufacturing as a way to imlement the technological potention of Russia
Authors: Кятова В.К. 
Published: July 2024

Авиастроение - одна из самых наукоемких отраслей современной промышленности. В России к ней традиционно приковано большое внимание не только специалистов, но и обычных граж дан. Несмотря на глобальное распространение международной изоляции, ОАК стремится сохранить свои ключевые компетенции в области проектирования, разработки и производства современных про грамм для коммерческих самолетов. Эти усилия, вызванные новой волной реформ в отрасли, направ лены на дальнейшее отделение коммерческого сегмента от оборонной промышленности.
Aircraft industry is one of the most science-intensive sectors of modern industry. In Russia, it is traditionally riveted to her great attention not only specialists, but also ordinary citizens.Despite the global spread of international isolation, UAC strives to maintain its core competencies in the design, development and produc tion of modern programs for commercial aircraft. These efforts, triggered by a new wave of reforms in the indus try, are aimed at further separating the commercial segment from the defense industry.
Социально-экономическое развитие Китая и цифровые трансформации
Authors: Шкваря Л.В. , Сичжэ Ван 
Published: July 2024

В статье представлен анализ динамики социально-экономического развития Китая в 2009-2018 гг. Автором обоснованы факторы роста китайской экономики и сохраняющиеся проблемы. Показана динамика ВВП и подушевых доходов, которая в XXI в. выше аналогичных среднемировых пока зателей. Автор приходит к выводу о преобладающей роли человеческого развития в Китае для ста новления и сохранения высоких темпов социально-экономической динамики. В статье обоснована роль внешнего фактора как имеющего основополагающий характер.
The article presents an analysis of the dynamics of social and economic development of China in 2009-2018. the Author justifies the factors of growth of the Chinese economy and the remaining problems. It shows the dynamics of GDP and per capita income, which in the XXI century is higher than the global average. The author comes to the conclusion about the predominant role of human development in China for the formation and preservation of high rates of socio-economic dynamics. The article substantiates the role of the external fac tor as having a fundamental character.