bluuebunny/crossref_metadata_2025_split huggingface dataset:
CYP19A1 promoter methylation in saliva associated with milestones of pubertal timing in urban girls
Authors: Stueve Theresa Ryan , Wolff Mary S , Pajak Ashley , Teitelbaum Susan L , Chen Jia 
Published: March 2014

Abstract

Background
Childhood obesity and early puberty are intermediate risk factors for later metabolic and reproductive disorders including diabetes, polycystic ovarian syndrome (PCOS), and breast cancer. Atypical methylation patterns in genes related to hormone and adipose metabolism, such as CYP19A1 (aromatase) and PPARG (peroxisome proliferator-activated receptor gamma), are associated with alterations in gene expression which may contribute to pathogenesis of these diseases. If present in early life, it is conceivable similar methylation aberrations may result in hormone perturbations that alter pubertal timing.

Methods
We used Cox proportional hazard models to investigate whether promoter methylation of CYP19A1 and PPARG, independently or in concert with body weight, was associated with age at breast (B2) or pubic hair development (PH2) when assayed in saliva DNA collected from a cohort of New York City, Black and Hispanic girls (N = 130) enrolled in a study of pubertal timing between 6–8 years of age.

Results
An inverse association between CYP19A1 methylation and risk of early PH2 was suggested (HR = 0.95, 95% CI = 0.90-1.00, p = 0.05). CYP19A1 methylation also appeared to modify risk of early B2 associated with body weight. Specifically, compared to normal weight girls with ‘high’ CYP19A1 methylation, significantly increased risk of early B2 was observed in overweight girls with ‘low’ but not ‘high’ CYP19A1 methylation (HR = 2.15; 95% CI = 1.23- 3.76). However, in formal tests for effect modification, the interaction between body weight and methylation did not reach statistical significance (p for interaction = 0.085). PPARG methylation was not significantly associated with PH2 or B2.

Conclusions
Though limited by sample size, our findings suggest methylation of CYP19A1, a critical gene in estrogen biosynthesis, may influence timing of breast development in overweight girls. Consistent with emerging reports, these data support the notion that epigenetic marks in surrogate tissues may improve risk prediction when added to standard plasma and anthropometric indicators, and warrant further study.
Novel application of simultaneous multi-image display during complex robotic abdominal procedures
Authors: Woo Yanghee , Choi Gi Hong , Min Byung Soh , Hyung Woo Jin 
Published: March 2014

Abstract

Background
The surgical robot offers the potential to integrate multiple views into the surgical console screen, and for the assistant’s monitors to provide real-time views of both fields of operation. This function has the potential to increase patient safety and surgical efficiency during an operation. Herein, we present a novel application of the multi-image display system for simultaneous visualization of endoscopic views during various complex robotic gastrointestinal operations.
All operations were performed using the da Vinci Surgical System (Intuitive Surgical, Sunnyvale, CA, USA) with the assistance of Tilepro, multi-input display software, during employment of the intraoperative scopes. Three robotic operations, left hepatectomy with intraoperative common bile duct exploration, low anterior resection, and radical distal subtotal gastrectomy with intracorporeal gastrojejunostomy, were performed by three different surgeons at a tertiary academic medical center.

Results
The three complex robotic abdominal operations were successfully completed without difficulty or intraoperative complications. The use of the Tilepro to simultaneously visualize the images from the colonoscope, gastroscope, and choledochoscope made it possible to perform additional intraoperative endoscopic procedures without extra monitors or interference with the operations.

Conclusion
We present a novel use of the multi-input display program on the da Vinci Surgical System to facilitate the performance of intraoperative endoscopies during complex robotic operations. Our study offers another potentially beneficial application of the robotic surgery platform toward integration and simplification of combining additional procedures with complex minimally invasive operations.
Local uniqueness solution of illuminated solar cell intrinsic electrical parameters
Authors: Jarray Abdennaceur , Abdelkrim Mahdi , Bouchiba Mohamed , Boukricha Abderrahman 
Published: March 2014

Abstract
Starting from an electrical dissipative illuminated one-diode solar cell with a given model data at room temperature (I

sc
, V

oc
, R

s0
, R

sh0
, I

max
); we present under physical considerations a specific mathematical method (using the Lambert function) for unique determination of the intrinsic electrical parameters (n, I

s
, I

ph
, R

s
, R

sh
). This work proves that for a given arbitrary fixed shunt resistance R

sh
, the saturation current I

S
and the ideality factor n are uniquely determined as a function of the photocurrent I

ph
, and the series resistance R

s
. The correspondence under the cited physical considerations: R

s
does not exceed ]0, 20[Ω and n is between ]0, 3[ and I

ph
and I

s
are arbitrary positive

I

R
+
*

, is biunivocal. This study concludes that for both considered solar cells, the five intrinsic electrical parameters that were determined numerically are unique.
Facile Synthesis of 3,3′-Disubstituted 2,2′-Binaphthyls by Transition-metal-catalyzed Double Benzannulation
Authors: Umeda Rui , Tabata Hiromasa , Tobe Yoshito , Nishiyama Yutaka 
Published: March 2014

Abstract
3,3′-Disubstituted 2,2′-binaphthyls were prepared by the Cu- or Re-catalyzed double benzannulation reaction of 2-(phenylethynyl)benzaldehyde with various butadiynes in the presence of trichloroacetic acid, in moderate to good yields. Acceleration of the second benzannulation was clearly observed.
Information Content When Mutual Funds Deviate from Benchmarks
Authors: Jiang Hao , Verbeek Marno , Wang Yu 
Published: March 2014

The consensus wisdom of active mutual fund managers, as reflected in their average over- and underweighting decisions, contains valuable information about future stock returns. Analyzing a comprehensive sample of active U.S. equity funds from 1984 to 2008, we find that stocks heavily overweighted by active funds outperform their underweighted counterparts by more than 7% per year, after adjustments for their loadings on the market, size, value, and momentum factors. This large premium dissipates quickly as the consensus view becomes publicly available. These results are consistent with the notion that informed investing by active mutual funds enhances the informativeness of stock prices. In addition, active mutual funds invest only a small portion of fund assets in high alpha stocks, in accordance with the consensus view that active mutual funds on average fail to outperform passive benchmarks. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2013.1847 . This paper was accepted by Brad Barber, finance.
Outcome assessment after hip fracture
Authors: Parsons N. , Griffin X. L. , Achten J. , Costa M. L. 
Published: March 2014

Objectives To study the measurement properties of a joint specific patient reported outcome measure, a measure of capability and a general health-related quality of life (HRQOL) tool in a large cohort of patients with a hip fracture. Methods Responsiveness and associations between the Oxford Hip Score (a hip specific measure: OHS), ICEpop CAPability (a measure of capability in older people: ICECAP-O) and EuroQol EQ-5D (general health-related quality of life measure: EQ-5D) were assessed using data available from two large prospective studies. The three outcome measures were assessed concurrently at a number of fixed follow-up time-points in a consecutive sequence of patients, allowing direct assessment of change from baseline, inter-measure associations and validity using a range of statistical methods. Results ICECAP-O was not responsive to change. EQ-5D was responsive to change from baseline, with an estimated standardised effect size for the two datasets of 0.676 and 0.644 at six weeks and four weeks respectively; this was almost as responsive to change as OHS (1.14 at four weeks). EQ-5D correlated strongly with OHS; Pearson correlation coefficients were 0.74, 0.77 and 0.70 at baseline, four weeks and four months. EQ-5D is a moderately good predictor of death at 12 months following hip fracture. Furthermore, EQ-5D reported by proxies (relatives and carers) behaves similarly to self-reported scores. Conclusions Our findings suggest that a general HRQOL tool such as EQ-5D could be used to measure outcome for patients recovering from hip fracture, including those with cognitive impairment. Cite this article: Bone Joint Res 2014;3:69–75.
The locations of memory: Migration and transnational cultural memory as challenges for art history
Authors: Petersen Anne Ring 
Published: March 2014

Abstract
In the contemporary world, a considerable number of artists are on the move, due to the triple processes of globalization, decolonization and migration. Migrant artists, and also cosmopolitan artists that travel widely, are transnational cultural workers with ties to several places. As ‘bridging persons’, migrant artists have more than one sense of home, and they play a seminal role in the translation between cultures, and in the transformations between the local and the global. However, the multiple cultural references in their works also raise the difficult question of the provenance of their art. This article addresses the issue of how transnational cultural memory is articulated in works by migrant artists, as well as how to access it analytically. After outlining the general issues concerning the impact of migration on contemporary art, the article explores the usefulness of three conceptual frameworks: hybridity (Homi Bhabha, Stuart Hall); migratory aesthetics (Mieke Bal); and the notion of the work of art as a migrant’s event (Syed Manzurul Islam). Taking British Palestinian artist Mona Hatoum as my example, it is my contention that her exhibition ‘Interior Landscape’ (Venice, 2009) constitutes a migrant’s event.
Marketing musicals: Commercializing the avant-garde in Spring Awakening
Authors: Hoskins Vicki L. 
Published: March 2014

Abstract
The creative team of Spring Awakening (2006) never anticipated the musical becoming a commercial success. Librettist Steven Sater, composer Duncan Sheik and director Michael Mayer all hoped that the musical would enjoy a modest off-off-Broadway run, but they never imagined it would find a home on the Great White Way. Rather, the creators sought to eschew musical theatre conventions and incorporate avant-garde theatricality in an effort to present an anti-Broadway (and therefore anti-establishment) mentality. This article examines Spring Awakening’s place within the avant-garde tradition against its success within the commercial sphere of Broadway. Can a commercially successful musical ever truly be thought of as avant-garde?
Making Broadway musicals: An interview with Jess Goldstein
Authors: Dee Das Joanna 
Published: March 2014

Abstract
Jess Goldstein has been the costume designer for a number of Broadway productions, including Love! Valour! Compassion! (1995), Jersey Boys (2005), The Apple Tree (2007) and Newsies (2012). He won a Tony Award for his work on The Rivals (2005). In addition to designing for Broadway, Goldstein has designed for the Woodland Opera, regional theatre, and a number of off-Broadway productions. He also teaches at the Yale School of Drama. Below are excerpts from a conversation among Goldstein (JG), Princeton undergraduate students Marjorie Kroll (MK), Gaku Liu (GL), and Nora Sullivan (NS), and members of a general public audience about the process of designing costumes for Broadway and Goldstein’s work on Newsies in particular. This conversation took place as a part of the Making Broadway Musicals: Artists and Scholars in Conversation symposium at Princeton University on 21 April 2012.
Reviews
Authors: Dinero Dan , Cox-Williams Briony , La Spina Riccardo , Martin George 
Published: March 2014

Abstract
Hard Times: The adult musical in 1970s New York City, Elizabeth L. Wollman (2013) Oxford, New York: Oxford University Press, 271 pp., ISBN: 978-0-19-974748-1, h/bk, $27.95
Richard Wagner’s Women, Eva Rieger, trans. Chris Walton (2009) Woodbridge, NY: The Boydell Press, 239 pp., ISBN: 9781843836858, h/bk, £30.00
Verdi in America: Oberto through Rigoletto, George W. Martin (2011) Rochester, NY: University of Rochester Press (Eastman Studies in Music), 4782 pp., ISBN:10 1580463886, ISBN:13 9781580463881, h/bk, £45
Verdi’s Il Trovatore, the Quintessential Italian Melodrama, Martin Chusid (2012) Rochester, NY: University of Rochester Press, 161 pp., ISBN: 13: 9781580464222, h/bk, £31.00
Spatio temporal and environmental factors influencing macroalgal β diversity in the Red Sea, Egypt
Authors: Issa Ahmed A. , Hifney Awatief F. , Abdel-Gawad Khayria M. , Gomaa Mohamed 
Published: March 2014

Abstract
β Diversity is an ecological concept used to describe the turnover of species across a wide range of spatial and temporal scales, but such knowledge is lacking for macroalgal assemblages of the Red Sea. β Diversity patterns for Red Sea macroalgae were evaluated from different sites (Hurghada, Safaga, and Al-Quseir) and seasons across different environmental disturbances. β Diversity was studied by partitioning the total number of species (γ diversity) into additive components. Geographical heterogeneity was more important than seasonal heterogeneity in structuring macroalgae both at species and functional group levels. Species replacement as a component of β diversity produced dissimilarity in species composition and taxonomic structure. Replacement of species between sites was responsible for the presence of new functional groups of macroalgae. High β diversity and taxonomic similarity values were characteristic of the macroalgae of the Red Sea. The occurrence of small macroalgal thalli that have short life cycles induced high species replacement and subsequently high β diversity, with spatial heterogeneity and environmental gradient as drivers of β diversity. Anthropogenic disturbance at the Safaga site was suggested to induce variation of macroalgal assemblages and functional groups. Excluding rare species from the data set did not change the high values of b diversity.
Accurate Measurement of the Photon Flux Received Inside Two Continuous Flow Microphotoreactors by Actinometry
Authors: Aillet Tristan , Loubiere Karine , Dechy-Cabaret Odile , Prat Laurent 
Published: March 2014

Abstract
In this study, the photon flux received in two continuous flow microphotoreactors was measured by actinometry (potassium ferrioxalate). The microphotoreactors had two different geometries and were irradiated by either a polychromatic or a monochromatic light source. A model considering the partial absorption of photons through the reactor depth and, if required, the polychromatic character of the light source and the dependence of the actinometer properties on the wavelength were formulated to describe the variation of the actinometer conversion with the irradiation time. The photon flux received in the microphotoreactors could be thus accurately calculated as a function of the emitted wavelength. The same methodology was then applied to measure the photon flux received in a batch immersion well photoreactor. The radiant power received in each photoreactor was compared to that emitted by the lamp and major differences were found, thus confirming the need for this kind of in situ measurement. Finally, some guidelines based on a knowledge of the photon flux were proposed to compare various photoreactors. They revealed in particular that the choice of the most efficient photoreactor depended on the criteria chosen to evaluate the performances (i.e. productivity, Space Time Yield).
A review on Ipomoea carnea: pharmacology, toxicology and phytochemistry
Authors: Fatima Nusrat , Rahman Mohammad Mijanur , Khan Md. Asaduzzaman , Fu Junjiang 
Published: March 2014

Abstract
Phytomedicines are increasingly being established in modern medical science. The shrub Ipomoea carnea has been used traditionally for thousands of years. However, there are few scientific studies on this medicinal plant, and most of the information are scattered. In this review, we have summarized the existing knowledge and recent progress on the medicinal importance of I. carnea. Different extracts of I. carnea plant possess anti-bacterial, anti-fungal, anti-oxidant, anti-cancer, anti-convulsant, immunomodulatory, anti-diabetic, hepatoprotective, anti-inflammatory, anxiolytic, sedative and wound healing activities. However, some toxicological effects have been also reported. Some of the major phytochemicals associated with the bioactivity of I. carnea have been characterized, which have been discussed in this study too. This review article might be beneficial for phytotherapy research, as I. carnea can be a good source for drug development.
Forward and Reverse Mappings in die Casting Process by Neural Network-based Approaches
Authors: Kittur Jayant K. , Parappagoudar M. B. 
Published: March 2014

Abstract
The primary objective of this research is to develop an effective process model to map process parameters on quality characteristics of a commercial die-cast part of aluminium alloy by utilizing Back Propagation and Genetic Neural Networks. In the neural network based forward mapping, die cast component properties have been expressed as the functions of input parameters, whereas attempts are made to determine an appropriate set of input parameters, to ensure a set of desired properties, in reverse mapping. In the present work, the problems related to both the forward as well as reverse mappings are tackled by using a back-propagation neural network (BPNN) and a genetic-neural network (GA-NN). The forward modeling consists of predicting the responses for a set of given process parameters, while reverse model provides the information process parameters for a set of desired responses. Batch mode of training is provided to both the networks with the help of one thousand data, generated artificially from the regression equations obtained earlier by the authors. The performances of both forward and reverse models based on BPNN have been compared with the help of twenty randomly generated test cases. The results show that, BPNN outperforms the GA-NN approach and that both the NN approaches are able to carry out the reverse mappings effectively.
Development and characterization of bronze-Cr-Ni composites produced by powder metallurgy
Authors: Canakci Aykut , Varol Temel , Cuvalci Hamdullah , Erdemir Fatih , Ozkaya Serdar 
Published: March 2014

AbstractIn this study, the bronze-Cr-Ni composites were prepared by means of the powder metallurgical method. The influence of the composition and compact pressure on microstructure, density, hardness and electrical conductivity was examined. Scanning electron microscope (SEM) and energy dispersive X-ray analysis (EDX) were used to analyze the microstructure of the contact materials. The results showed that density of the bronze-Cr-Ni composites decreased with increasing Ni content. Increasing compact pressure led to lower porosity and consequently improved the density of bronze-Cr-Ni composites. The relative green density increased from 78% to 95% with the increase in the compact pressure from 200 MPa to 800 MPa. The hardness values showed a decrease from 95.1 BHN to 71.6 BHN by the addition of Ni from 1 wt% to 5 wt% at 800 MPa. It was found that addition of Ni at 1 wt% was required to achieve increased hardness and sufficient conductivity for bronze-Cr-Ni composites. The electrical conductivities of contact materials containing 3 wt% Ni and 5 wt% Ni was lower than that of 1 wt% Ni.
A case of ectopic ACTH syndrome treated with intermittent administration of dopamine agonists
Authors: Sakihara Satoru , Kageyama Kazunori , Yamagata Satoshi , Terui Ken , Daimon Makoto , Suda Toshihiro 
Published: March 2014

SummaryACTH-dependent Cushing's syndrome includes Cushing's disease and ectopic ACTH syndrome (EAS). The differential diagnosis of Cushing's disease from EAS in cases of ACTH-dependent Cushing's syndrome is a challenging problem. We report here a case of EAS with an unknown source of ACTH secretion. Extensive imaging procedures, involving computed tomography (neck to pelvis), pituitary magnetic resonance imaging, and whole-body18F-fluorodeoxyglucose-positron emission tomography, failed to reveal the source of ACTH secretion. Intermittent administration of bromocriptine, a short-acting and nonselective dopamine agonist, has afforded adequate suppression of plasma ACTH and cortisol levels over the long term.Learning pointsTumor excision is the primary treatment for EAS. However, when surgery is impossible, medical therapy is needed to treat hypercortisolism.In cases where the source of ACTH secretion is unknown, inhibitors of steroidogenesis, such as metyrapone, mitotane, ketoconazole, and etomidate, are mostly used to suppress cortisol secretion.Medications that suppress ACTH secretion are less effective, therefore less popular, as standard treatments.In the present case, short-term treatment with dopamine agonists was effective for the long-term suppression of both ACTH and cortisol levels.
Diverse Cell Type-Specific Mechanisms Localize G Protein-Coupled Receptors to Caenorhabditis elegans Sensory Cilia
Authors: Brear Andrea G , Yoon Jason , Wojtyniak Martin , Sengupta Piali 
Published: March 2014

Abstract
The localization of signaling molecules such as G protein-coupled receptors (GPCRs) to primary cilia is essential for correct signal transduction. Detailed studies over the past decade have begun to elucidate the diverse sequences and trafficking mechanisms that sort and transport GPCRs to the ciliary compartment. However, a systematic analysis of the pathways required for ciliary targeting of multiple GPCRs in different cell types in vivo has not been reported. Here we describe the sequences and proteins required to localize GPCRs to the cilia of the AWB and ASK sensory neuron types in Caenorhabditis elegans. We find that GPCRs expressed in AWB or ASK utilize conserved and novel sequences for ciliary localization, and that the requirement for a ciliary targeting sequence in a given GPCR is different in different neuron types. Consistent with the presence of multiple ciliary targeting sequences, we identify diverse proteins required for ciliary localization of individual GPCRs in AWB and ASK. In particular, we show that the TUB-1 Tubby protein is required for ciliary localization of a subset of GPCRs, implying that defects in GPCR localization may be causal to the metabolic phenotypes of tub-1 mutants. Together, our results describe a remarkable complexity of mechanisms that act in a protein- and cell-specific manner to localize GPCRs to cilia, and suggest that this diversity allows for precise regulation of GPCR-mediated signaling as a function of external and internal context.