bluuebunny/crossref_metadata_2025_split huggingface dataset:
Between universalism and regionalism: universal systematics from imperial Japan
Authors: LEE JUNG 
Published: September 2015

AbstractHistoriographic discussions of the universality and regionality of science have to date focused on European cases for making regional science universal. This paper presents a new perspective by moving beyond European origins and illuminating a non-European scientist's engagement with the universality and regionality of science. It will examine the case of the Japanese botanist Nakai Takenoshin (1882–1952), an internationally recognized authority on Korean flora based at Tokyo Imperial University. Serving on the International Committee on Botanical Nomenclature in 1926, Nakai endorsed and acted upon European claims of universal science, whilst simultaneously unsettling them with his regionally shaped systematics. Eventually he came to promote his own systematics, built regionally on Korean flora, as the new universal. By analysing his shifting claims in relation to those of other European and non-European botanists, this paper makes two arguments. First, universalism and regionalism were not contradictory foundations of scientific practice but useful tools used by this non-European botanist in maintaining his scientific authority as a representative Japanese systematist. Second, his claims to universality and regionalism were both imperially charged. An imperially monopolized study of Korean plants left a regional imprint on Nakai's systematics. In order to maintain his scientific authority beyond its region of origin he had to assert either the expanding regionalism of ‘East Asia’ or universalism.
Smartphone apps for snoring
Authors: Camacho M , Robertson M , Abdullatif J , Certal V , Kram Y A , Ruoff C M , Brietzke S E , Capasso R 
Published: September 2015

AbstractObjective:To identify and systematically evaluate user-friendly smartphone snoring apps.Methods:The Apple iTunes app store was searched for snoring apps that allow recording and playback. Snoring apps were downloaded, evaluated and rated independently by four authors. Two patients underwent polysomnography, and the data were compared with simultaneous snoring app recordings, and one patient used the snoring app at home.Results:Of 126 snoring apps, 13 met the inclusion and exclusion criteria. The most critical app feature was the ability to graphically display the snoring events. The Quit Snoring app received the highest overall rating. When this app's recordings were compared with in-laboratory polysomnography data, app snoring sensitivities ranged from 64 to 96 per cent, and snoring positive predictive values ranged from 93 to 96 per cent. A chronic snorer used the app nightly for one month and tracked medical interventions. Snoring decreased from 200 to 10 snores per hour, and bed partner snoring complaint scores decreased from 9 to 2 (on a 0–10 scale).Conclusion:Select smartphone apps are user-friendly for recording and playing back snoring sounds. Preliminary comparison of more than 1500 individual snores demonstrates the potential clinical utility of such apps; however, further validation testing is recommended.
Rediscovering confidence as a mechanism and optimism as a construct
Authors: Carver Charles S. , Scheier Michael F. 
Published: September 2015

AbstractThe target article asserts that resilience results from a generalized tendency to appraise stressful circumstances positively. Apparently unbeknownst to the authors, essentially the same idea has been advanced before and studied extensively from a different research perspective. This raises a broader issue: the critical need, when projects attempt to span disciplines, to fully examine work from all relevant backgrounds.
Programming multi-agent systems
Authors: Dastani Mehdi 
Published: September 2015

AbstractWith the significant advances in the area of autonomous agents and multi-agent systems in the last decade, promising technologies for the development and engineering of multi-agent systems have emerged. The result is a variety of agent-oriented programming languages, development frameworks, execution platforms, and tools that facilitate building and engineering of multi-agent systems. This paper provides an overview of the multi-agent programming research field and explains the aim and characteristics of various multi-agent programming languages and development frameworks. This overview is complemented with a discussion on the current trends and challenges in this research community.
Semantics of templates in a compositional framework for building logics
Authors: DASSEVILLE INGMAR , VAN DER HALLEN MATTHIAS , JANSSENS GERDA , DENECKER MARC 
Published: September 2015

AbstractThere is a growing need for abstractions in logic specification languages such as FO(·) and ASP. One technique to achieve these abstractions are templates (sometimes called macros). While the semantics of templates are virtually always described through a syntactical rewriting scheme, we present an alternative view on templates as second order definitions. To extend the existing definition construct of FO(·) to second order, we introduce a powerful compositional framework for defining logics by modular integration of logic constructs specified as pairs of one syntactical and one semantical inductive rule. We use the framework to build a logic of nested second order definitions suitable to express templates. We show that under suitable restrictions, the view of templates as macros is semantically correct and that adding them does not extend the descriptive complexity of the base logic, which is in line with results of existing approaches.
Can a medical need clause help manage the growing costs of prescription drugs in the EU?
Authors: Brooks Eleanor , Geyer Robert 
Published: September 2015

AbstractInnovation in the development of new drugs has to balance the needs of health actors and administrators, the pharmaceutical industry and patients. Differing perspectives on what constitutes an innovation, where research and development should be directed and how new drugs should be evaluated and priced cause ongoing tensions within the regulatory framework. In the current climate, where Europe’s health systems face rising demand for health services and increasingly restricted resources, the efficiency of pharmaceutical regulation and drug development is under even greater scrutiny. How can regulation foster innovation and industry growth while also serving the public health needs of society, and what is the EU’s role in pursuing this objective? Drawing on a provision which formerly existed in Norwegian pharmaceutical legislation, this article explores the potential of a medical need clause (MNC) in addressing these issues. In restricting market authorisations to those drugs that offer an added therapeutic value, might a MNC foster innovation and spending efficiency in Europe’s health systems?
The Validity of the Short UK Health and Safety Executive Stress Indicator Tool For the Assessment of the Psychosocial Work Environment in Italy
Authors: Balducci Cristian , Romeo Luciano , Brondino Margherita , Lazzarini Gianluigi , Benedetti Francesca , Toderi Stefano , Fraccaroli Franco , Pasini Margherita 
Published: September 2015

Abstract. The Health and Safety Executive Stress Indicator Tool (SIT) is a 35-item questionnaire to assess exposure to seven common psychosocial factors involved in the genesis of work-related stress. Recent work conducted in the UK has provided evidence that the SIT may be reduced to a 25-item questionnaire (the SIT-25) showing the same seven-factor model and criterion-related validity of the SIT. The SIT is the most widely used tool to assess work-related stress factors in Italy, with benchmark (normative) data managed by the Italian Workers’ Compensation Authority. Thus, we conducted two studies to further test whether in Italy the SIT may be reduced to the SIT-25. In Study 1 a heterogeneous sample of workers (N = 588, 39.5% females) was used to further test the seven-factor model of the SIT-25 and its criterion-related validity with mental well-being. In Study 2 two new samples of workers (N = 625, 69.8% females; and N = 344, 3.2% females) from health and metal-mechanical sectors were used to assess the degree of measurement invariance of the SIT-25 and further test its criterion-related validity. Overall the results showed that the SIT-25 data fit the postulated seven-factor solution and that the reduced subscales (i.e., Demands, Control, Relationships, and Role) have the same criterion-related validity as their longer version. Additionally, the SIT-25 showed strong measurement invariance in the two different samples of workers of Study 2. These results provide further encouraging evidence that the SIT-25 may be effectively used in place of its longer version.
Diagnostic Concordance Between Categorical and Dimensional Instruments to Assess Personality Disorder in Chronic Fatigue Syndrome
Authors: Calvo Natalia , Sáez-Francàs Naia , Valero Sergi , Castro-Marrero Jesús , Alegre Martín José , Casas Miquel 
Published: September 2015

Abstract. The study examines the relationship between a categorical and a dimensional personality assessment instrument in patients with Chronic Fatigue Syndrome (CFS). A total of 162 CFS patients were included in the study (91.4% women; mean age 47.5 years). All subjects completed the Spanish versions of the Personality Diagnostic Questionnaire-4+ (PDQ-4+) and the Temperament and Character Inventory-Revised (TCI-R). Results: 78 (48.1%) of the patients presented a Personality Disorder (PD), the most frequent being Cluster C, specifically Obsessive-compulsive disorder, followed by Avoidant disorder. PDs showed a specific pattern of correlation with temperament scales. All PD clusters correlated positively with Harm Avoidance and Self-Transcendence, and negatively with Reward Dependence, Self-Directedness, and Cooperativeness. In a logistic regression analysis, Self-Directedness and Cooperativeness predicted PD presence. The findings are consistent with previous studies in non-CFS samples and suggest that the combination of the Temperament and Character dimensions (low Self-Directedness and Cooperativeness and high Harm Avoidance and Self-Transcendence) correlates with PD severity, and that Self-Directedness and Cooperativeness are associated with PD presence in CFS patients. The integration of these two perspectives expands the current comprehension of personality pathology in CFS patients.
Inhibition of autophagy in EBV-positive Burkitt’s lymphoma cells enhances EBV lytic genes expression and replication
Authors: De Leo A , Colavita F , Ciccosanti F , Fimia G M , Lieberman P M , Mattia E 
Published: September 2015

AbstractAutophagy, an important degradation system involved in maintaining cellular homeostasis, serves also to eliminate pathogens and process their fragments for presentation to the immune system. Several viruses have been shown to interact with the host autophagic machinery to suppress or make use of this cellular catabolic pathway to enhance their survival and replication. Epstein Barr virus (EBV) is a γ-herpes virus associated with a number of malignancies of epithelial and lymphoid origin in which establishes a predominantly latent infection. Latent EBV can periodically reactivate to produce infectious particles that allow the virus to spread and can lead to the death of the infected cell. In this study, we analyzed the relationship between autophagy and EBV reactivation in Burkitt’s lymphoma cells. By monitoring autophagy markers and EBV lytic genes expression, we demonstrate that autophagy is enhanced in the early phases of EBV lytic activation but decreases thereafter concomitantly with increased levels of EBV lytic proteins. In a cell line defective for late antigens expression, we found an inverse correlation between EBV early antigens expression and autophagosomes formation, suggesting that early after activation, the virus is able to suppress autophagy. We report here for the first time that inhibition of autophagy by Bafilomycin A1 or shRNA knockdown of Beclin1 gene, highly incremented EBV lytic genes expression as well as intracellular viral DNA and viral progeny yield. Taken together, these findings indicate that EBV activation induces the autophagic response, which is soon inhibited by the expression of EBV early lytic products. Moreover, our findings open the possibility that pharmacological inhibitors of autophagy may be used to enhance oncolytic viral therapy of EBV-related lymphomas.
Myelin-associated glycoprotein modulates apoptosis of motoneurons during early postnatal development via NgR/p75NTR receptor-mediated activation of RhoA signaling pathways
Authors: Palandri A , Salvador V R , Wojnacki J , Vivinetto A L , Schnaar R L , Lopez P H H 
Published: September 2015

AbstractMyelin-associated glycoprotein (MAG) is a minor constituent of nervous system myelin, selectively expressed on the periaxonal myelin wrap. By engaging multiple axonal receptors, including Nogo-receptors (NgRs), MAG exerts a nurturing and protective effect the axons it ensheaths. Pharmacological activation of NgRs has a modulatory role on p75NTR-dependent postnatal apoptosis of motoneurons (MNs). However, it is not clear whether this reflects a physiological role of NgRs in MN development. NgRs are part of a multimeric receptor complex, which includes p75NTR, Lingo-1 and gangliosides. Upon ligand binding, this multimeric complex activates RhoA/ROCK signaling in a p75NTR-dependent manner. The aim of this study was to analyze a possible modulatory role of MAG on MN apoptosis during postnatal development. A time course study showed thatMag-null mice suffer a loss of MNs during the first postnatal week. Also, these mice exhibited increased susceptibility in an animal model of p75NTR-dependent MN apoptosis induced by nerve-crush injury, which was prevented by treatment with a soluble form of MAG (MAG-Fc). The protective role of MAG was confirmed inin vitromodels of p75NTR-dependent MN apoptosis using the MN1 cell line and primary cultures. Lentiviral expression of shRNA sequences targeting NgRs on these cells abolished protection by MAG-Fc. Analysis of RhoA activity using a FRET-based RhoA biosensor showed that MAG-Fc activates RhoA. Pharmacological inhibition of p75NTR/RhoA/ROCK pathway, or overexpression of a p75NTRmutant unable to activate RhoA, completely blocked MAG-Fc protection against apoptosis. The role of RhoA/ROCK signaling was further confirmed in the nerve-crush model, where pretreatment with ROCK inhibitor Y-27632 blocked the pro-survival effect of MAG-Fc. These findings identify a new protective role of MAG as a modulator of apoptosis of MNs during postnatal development by a mechanism involving the p75NTR/RhoA/ROCK signaling pathway. Also, our results highlight the relevance of the nurture/protective effects of myelin on neurons.
The p53 co-activator Zac1 neither induces cell cycle arrest nor apoptosis in chicken Lim1 horizontal progenitor cells
Authors: Fard S Shirazi , Blixt MKE , Hallböök F 
Published: September 2015

AbstractChicken horizontal progenitor cells are able to enter their final mitosis even in the presence of DNA damage despite having a functional p53-p21 system. This suggests that they are resistant to DNA damage and that the regulation of the final cell cycle of horizontal progenitor cells is independent of the p53-p21 system. The activity of p53 is regulated by positive and negative modulators, including the zinc finger containing transcription factor Zac1 (zinc finger protein that regulates apoptosis and cell cycle arrest). Zac1 interacts with and enhances the activity of p53, thereby inducing cell cycle arrest and apoptosis. In this work, we use a gain-of-function assay in which mouse Zac1 (mZac1) is overexpressed in chicken retinal progenitor cells to study the effect on the final cell cycle of horizontal progenitor cells. The results showed that overexpression of mZac1 induced expression of p21 in a p53-dependent way and arrested the cell cycle as well as triggered apoptosis in chicken non-horizontal retinal progenitor cells. The negative regulation of the cell cycle by mZac1 is consistent with its proposed role as a tumour-suppressor gene. However, the horizontal cells were not affected by mZac1 overexpression. They progressed into S- and late G2/M-phase despite overexpression of mZac1. The inability of mZac1 to arrest the cell cycle in horizontal progenitor cells support the notion that the horizontal cells are less sensitive to events that triggers the p53 system during their terminal and neurogenic cell cycle, compared with other retinal cells. These properties are associated with a cell that has a propensity to become neoplastic and thus with a cell that may develop retinoblastoma.
A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism
Authors: Krarup Anders , Truan Daphné , Furmanova-Hollenstein Polina , Bogaert Lies , Bouchier Pascale , Bisschop Ilona J. M. , Widjojoatmodjo Myra N. , Zahn Roland , Schuitemaker Hanneke , McLellan Jason S. , Langedijk Johannes P. M. 
Published: September 2015

AbstractRespiratory syncytial virus (RSV) causes acute lower respiratory tract infections and is the leading cause of infant hospitalizations. Recently, a promising vaccine antigen based on the RSV fusion protein (RSV F) stabilized in the native prefusion conformation has been described. Here we report alternative strategies to arrest RSV F in the prefusion conformation based on the prevention of hinge movements in the first refolding region and the elimination of proteolytic exposure of the fusion peptide. A limited number of unique mutations are identified that stabilize the prefusion conformation of RSV F and dramatically increase expression levels. This highly stable prefusion RSV F elicits neutralizing antibodies in cotton rats and induces complete protection against viral challenge. Moreover, the structural and biochemical analysis of the prefusion variants suggests a function for p27, the excised segment that precedes the fusion peptide in the polypeptide chain.
Fractal dendrite-based electrically conductive composites for laser-scribed flexible circuits
Authors: Yang Cheng , Cui Xiaoya , Zhang Zhexu , Chiang Sum Wai , Lin Wei , Duan Huan , Li Jia , Kang Feiyu , Wong Ching-Ping 
Published: September 2015

AbstractFractal metallic dendrites have been drawing more attentions recently, yet they have rarely been explored in electronic printing or packaging applications because of the great challenges in large-scale synthesis and limited understanding in such applications. Here we demonstrate a controllable synthesis of fractal Ag micro-dendrites at the hundred-gram scale. When used as the fillers for isotropically electrically conductive composites (ECCs), the unique three-dimensional fractal geometrical configuration and low-temperature sintering characteristic render the Ag micro dendrites with an ultra-low electrical percolation threshold of 0.97 vol% (8 wt%). The ultra-low percolation threshold and self-limited fusing ability may address some critical challenges in current interconnect technology for microelectronics. For example, only half of the laser-scribe energy is needed to pattern fine circuit lines printed using the present ECCs, showing great potential for wiring ultrathin circuits for high performance flexible electronics.
Projected phase-change memory devices
Authors: Koelmans Wabe W. , Sebastian Abu , Jonnalagadda Vara Prasad , Krebs Daniel , Dellmann Laurent , Eleftheriou Evangelos 
Published: September 2015

AbstractNanoscale memory devices, whose resistance depends on the history of the electric signals applied, could become critical building blocks in new computing paradigms, such as brain-inspired computing and memcomputing. However, there are key challenges to overcome, such as the high programming power required, noise and resistance drift. Here, to address these, we present the concept of a projected memory device, whose distinguishing feature is that the physical mechanism of resistance storage is decoupled from the information-retrieval process. We designed and fabricated projected memory devices based on the phase-change storage mechanism and convincingly demonstrate the concept through detailed experimentation, supported by extensive modelling and finite-element simulations. The projected memory devices exhibit remarkably low drift and excellent noise performance. We also demonstrate active control and customization of the programming characteristics of the device that reliably realize a multitude of resistance states.
Two-photon-like microscopy with orders-of-magnitude lower illumination intensity via two-step fluorescence
Authors: Ingaramo Maria , York Andrew G. , Andrade Eric J. , Rainey Kristin , Patterson George H. 
Published: September 2015

AbstractWe describe two-step fluorescence microscopy, a new approach to non-linear imaging based on positive reversible photoswitchable fluorescent probes. The protein Padron approximates ideal two-step fluorescent behaviour: it equilibrates to an inactive state, converts to an active state under blue light, and blue light also excites this active state to fluoresce. Both activation and excitation are linear processes, but the total fluorescent signal is quadratic, proportional to the square of the illumination dose. Here, we use Padron’s quadratic non-linearity to demonstrate the principle of two-step microscopy, similar in principle to two-photon microscopy but with orders-of-magnitude better cross-section. As with two-photon, quadratic non-linearity from two-step fluorescence improves resolution and reduces unwanted out-of-focus excitation, and is compatible with structured illumination microscopy. We also show two-step and two-photon imaging can be combined to give quartic non-linearity, further improving imaging in challenging samples. With further improvements, two-step fluorophores could replace conventional fluorophores for many imaging applications.
High-resolution non-contact measurement of the electrical activity of plants in situ using optical recording
Authors: Zhao Dong-Jie , Chen Yang , Wang Zi-Yang , Xue Lin , Mao Tong-Lin , Liu Yi-Min , Wang Zhong-Yi , Huang Lan 
Published: September 2015

AbstractThe limitations of conventional extracellular recording and intracellular recording make high-resolution multisite recording of plant bioelectrical activity in situ challenging. By combining a cooled charge-coupled device camera with a voltage-sensitive dye, we recorded the action potentials in the stem of Helianthus annuus and variation potentials at multiple sites simultaneously with high spatial resolution. The method of signal processing using coherence analysis was used to determine the synchronization of the selected signals. Our results provide direct visualization of the phloem, which is the distribution region of the electrical activities in the stem and leaf of H. annuus and verify that the phloem is the main action potential transmission route in the stems of higher plants. Finally, the method of optical recording offers a unique opportunity to map the dynamic bioelectrical activity and provides an insight into the mechanisms of long-distance electrical signal transmission in higher plants.