bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymerization‐Induced Emission and Specific Detection to Cu2+ Ions of Polyacrylates with Morpholine Structure
Authors: Feng Yayu , Fan Enze , Liu Yunfei , Gao Rumeng , Wang Lin , Deng Kuilin 
Published: July 2024

AbstractIn this investigation, the fluorescent poly(N‐hydroxyethyl morpholine acrylate) (PHEMA) and poly(N‐hydroxypropyl morpholine acrylate) (PHPMA) are prepared and applied as fluorescent probes for the specific detection of Cu2+ ions. Far different from the non‐fluorescent monomer, PHEMA and PHPMA emit a strong fluorescence at 410 nm due to the intramolecular aggregation of morpholine structures along macromolecular chains in the polymerization, indicating polymerization‐induced emission (PIE). The fluorescent emission of PHPMA shows the dependence on external factors including solution concentration, excitation wavelength, solvent, and pH value. PHPMA specifically detects Cu2+ ions even in the presence of 16 common metal ions and 6 anions, with an LOD of 0.077 µM. In the fluorescent quenching, the O atom from ─C═O and N atom from morpholine moiety on the PHPMA chain participate in the complexation with Cu2+ ions with the ratio of the structural unit and Cu2+ ion of 2:1, leading to the dynamic quenching of PHPMA solution. As for the application, PIE‐active PHPMA is easily made into a portable semi‐quantitative filter paper with recyclability. In brief, the PIE‐active PHPMA synthesized in this study can be used as a promising material for the specific detection of Cu2+ ions in industry, agriculture, and medicine fields.
Firm‐level climate risk and corporate violations: Perspective of corporate managers' pressure perception
Authors: Sun Xiaonan , Ci Fanghui , Cifuentes‐Faura Javier , Liu Xiaoqian 
Published: July 2024

AbstractThis study is grounded in the perspective of pressure perception, examining how a company's awareness of climate risk influences its propensity for violations. The study reveals that an enhanced perception of climate risks is correlated with an increased likelihood of such behaviors. This effect is primarily mediated through a mechanism of stress transmission, exacerbating the myopia and rent‐seeking activities of corporate managers. Furthermore, this study integrates a heterogeneity analysis within the framework of the fraud triangle theory to explore strategies for mitigating the impact of climate risk perception on corporate violations. The findings indicate that the influence of climate risk perception on corporate violations becomes insignificant under certain conditions: when companies offer strong equity incentives to managers, thus alleviating pressure; when companies are heavily influenced by Confucian culture, thereby reducing rationalizations; and when companies possess robust internal governance and are subject to stringent external oversight, thereby diminishing opportunities for violations. This study not only validates the pressure transmission mechanism of climate risk but also proposes avenues for mitigating the onset of non‐compliant behaviors induced by the perception of climate risk.
The effect of fat model variation on muscle fat fraction quantification in a cross‐sectional cohort
Authors: Froeling Martijn , Heskamp Linda 
Published: July 2024

AbstractSpectroscopic imaging, rooted in Dixon's two‐echo spin sequence to distinguish water and fat, has evolved significantly in acquisition and processing. Yet precise fat quantification remains a persistent challenge in ongoing research. With adequate phase characterization and correction, the fat composition models will impact measurements of fatty tissue. However, the effect of the used fat model in low‐fat regions such as healthy muscle is unknown. In this study, we investigate the effect of assumed fat composition, in terms of chain length and double bond count, on fat fraction quantification in healthy muscle, while addressing phase and relaxometry confounders. For this purpose, we acquired bilateral thigh datasets from 38 healthy volunteers. Fat fractions were estimated using the IDEAL algorithm employing three different fat models fitted with and without the initial phase constrained. After data processing and model fitting, we used a convolutional neural net to automatically segment all thigh muscles and subcutaneous fat to evaluate the fitted parameters. The fat composition was compared with those reported in the literature. Overall, all the observed estimated fat composition values fall within the range of previously reported fatty acid composition based on gas chromatography measurements. All methods and models revealed different estimates of the muscle fat fractions in various evaluated muscle groups. Lateral differences changed from 0.5% to 5.3% in the hamstring muscle groups depending on the chosen method. The lowest observed left–right differences in each muscle group were all for the fat model estimating the number of double bonds with the initial phase unconstrained. With this model, the left–right differences were 0.64% ± 0.31%, 0.50% ± 0.27%, and 0.50% ± 0.40% for the quadriceps, hamstrings, and adductors muscle groups, respectively. Our findings suggest that a fat model estimating double bond numbers while allowing separate phases for each chemical species, given some assumptions, yields the best fat fraction estimate for our dataset.
Effective use of yokukansan for Caucasian patient with panic disorder: A case report
Authors: Ohsako Noriaki , Kimura Hiroshi 
Published: July 2024

AbstractBackgroundYokukansan is a traditional Japanese herbal medicine that is widely administered to individuals of various age groups as an effective drug for anxiety, with few side‐effects. While animal studies have yielded promising results concerning yokukansan's potential in treating anxiety disorders, comprehensive validation has remained incomplete. Moreover, most of the clinical investigations regarding yokukansan have primarily focused on Japanese subjects, and its impact on non‐Asian ethnicities remains unverified.Case PresentationWe present the case of a 17‐year‐old Caucasian female with panic disorder (PD). Following her relocation to Japan, she experienced panic attacks due to environmental changes, which subsequently prompted her to visit to our clinic. Various medical examinations revealed no abnormalities, which ruled out the possibility of any physical illness other than PD. Significantly, the administration of yokukansan resulted in a notable reduction in panic attacks, as well as in anticipatory anxiety, accompanied by discernible enhancements in psychosocial functioning and overall quality of life. Furthermore, it is imperative to underscore the fact that no noteworthy adverse events took place.ConclusionPanic attacks and profound anxiety in a Caucasian patient with PD were successfully treated with the use of yokukansan. This case study suggests that yokukansan may be effective in treating PD in Caucasians as well as in Asians. However, to substantiate this preliminary observation, further investigations are required.
Fixed dose daptomycin: An opportunity for pharmacokinetic/pharmacodynamic optimization in Staphylococcus aureus infections
Authors: Olney Katie B. , Pai Manjunath P. , Thomas Jenni K. , Burgess Donna R. , Olney William J. , Bruning Rebecca A. , Griffith Kamron A. , Casaus Danielle V. , Crance Elizabeth , Porterfield James Z. , Burgess David S. 
Published: July 2024

AbstractBackgroundDaptomycin is a high‐use intravenous antimicrobial agent affording the convenience of once‐daily dosing. Prior studies suggest an opportunity to use a more operationally convenient fixed rather than weight‐based dosing but this approach has not been studied prospectively.MethodsThis study quantified the probability of toxicity and efficacy end points by prospectively testing a fixed dose regimen of daptomycin (750 mg) in obese and non‐obese adults. At least, three daptomycin concentrations were measured at steady‐state for each patient. A population pharmacokinetic model was constructed to evaluate concentration‐time profiles and investigate covariates of daptomycin clearance. Simulations were performed to evaluate the probability of achieving efficacy (24‐h area under the curve (AUC0‐24) ≥ 666 mg∙h/L) and toxicity (minimum concentration (C
min) ≥24.3 mg/L) targets for fixed (500–1000 mg) and weight‐based (6–12 mg/kg) daptomycin doses.ResultsThirty‐one patients (16 females, 15 males) with median (interquartile range (IQR)) age of 50 (30, 62) years and weight of 74 (54, 156) kg were included in the final analysis. Fixed dose daptomycin (750 mg) resulted in similar exposure across weights with a median (IQR) AUC0‐24 of 819 (499, 1501) mg∙h/L and 749 (606, 1265) mg∙h/L in patients weighing ≤74 kg and >74 kg, respectively. Overall, male sex and increased kidney function necessitate higher fixed and weight‐based doses to achieve efficacy. Creatine phosphokinase elevation was observed in two patients (6.5%) and predicted to be lower with fixed versus weight‐based regimens.ConclusionsFixed daptomycin dosing adjusted for sex and kidney function is expected to improve the efficacy‐to‐toxicity ratio, transitions of care, and costs compared to weight‐based doses. However, no empiric dosing approach is predicted to achieve ≥90% efficacy while minimizing the risk of toxicity, so therapeutic drug monitoring should be considered on a patient‐specific basis.
9‐3: The Latest Technology Breakthroughs for 31” 4K Flexible Printed OLED TV Display Technology
Authors: Lee Jueng Gil (James) , Gao Zhuo , Dong Ting , Yu Lei , Fu Dong , Yan Xiaolin , Chang Bong Seok 
Published: July 2024

The flexible printed OLED TV display technology will be able to create new application market, such as rollable/foldable TV, in the future. It's TV Mobiles. Since the TCL (TCL CSOT, Guangdong Juhua Printed Display Technology Co. Ltd. & TCL Corporate Research) has successfully demonstrated the 31” FHD flexible printed OLED TV, there are a lot of technology breakthroughs for improving the panel performance and cost reduction. The co‐planar top gate Oxide TFT device architecture, printing OLED top emission device architecture with new OLED materials, MURA free ink jet printing technology with unique bank design, advanced encapsulation technology with new inorganic material for panel performance improvement are developed. Especially innovative mechanical release technology without using laser lift off technology is developed for cost reduction and production yield up in flexible printed OLED TV MP line. Based on these technology breakthroughs, 31” 4K flexible printed OLED TV with high resolution(142ppi) are fabricated.The performance of 31” flexible printed OLED TV is, 4K high resolution (3840x2160, 142ppi), luminance: FW 150nits, excellent C/R; > 1M:1, color gamut: DCI‐P3: >99%, wide viewing angle (Δu'v' < 0.02): ≥ +/‐ 45°, A/R: 47.75%, and curvature radius: 20mmIn this paper, the panel performance of 31” 4K high resolution flexible printed OLED TV and the latest technology breakthroughs are discussed in details.
27‐1: Flat‐based Double Path Pancake Optics to Improve Productivity
Authors: Usukura Naru , Yoshida Takehisa , Minoura Kiyoshi , Honma Yoshiko 
Published: July 2024

We proposed highly light efficient pancake Head Mounted Display (HMD) optics named “Double path pancake optics” last year, which has 1.8 times higher light efficiency than conventional one.While maintaining such high optical efficiency, this year, we have improved its productivity by replacing curved Reflective Polarizer (RP) with flat one. To realize a structure with flat RP, we have simulated optical concepts and finally found appropriate design. According to our optimized optical design, 25.5 mm thickness with 90 deg Field Of View (FOV) was realized and we have successfully made the prototype and confirmed that the high image quality can be displayed and optical properties are almost the same as our previous one with curved RP.
52‐2: Invited Paper: 1µm Nanowire Based MicroLED Chips for Efficient and High Performance Smart Watch Displays
Authors: Robin Ivan-Christophe , Thulian Pierre , Sannicolo Thomas , Malier Yoann , Hugon Xavier , Gilet Philippe 
Published: July 2024

One of the microLED direct view display major challenges is to find ways of drastically dropping the cost, for instance by reducing the microLED size, simplifying the assembly process, and improving the assembly yield.Aledia has developed a 3D nanowire (NW) microLED technology on 8” silicon wafers which has the outstanding capability to keep the same efficiency for <4µm size devices containing only 1NW as for larger devices containing hundreds of NWs. This technology provides similar efficiency as well as electro‐optical parameters (I‐V and Emission Spectra) whatever the microLED size. Over 30% Wall Plug Efficiency (WPE) is obtained and 3% WPE standard deviation is measured at wafer level as well as a wavelength standard deviation as low as 1.5 nm. Those results show that our technology allowsthe manufacturing of micron size microLEDs on a Si platform without experiencing a loss of efficiency with size reduction. We will present our technology and its performance. Based on our microLED we will also propose a cost competitive and energy efficient direct‐view smartwatch display architecture.
57‐1: Invited Paper: Key challenges for the qualification of vehicle displays
Authors: Kreuzer Markus , Hudak Andreas , Pluta Alexander , Song Kiuk , Adam P 
Published: July 2024

Today, automotive displays are among the innovators for high‐resolution, free‐form, curved and flexible displays with immense demands on durability, brightness and color fidelity. These ever‐increasing requirements go hand in hand with the future‐oriented changes in mobility. The importance of displays, especially in semi‐autonomous and autonomous vehicles, is constantly increasing. At the same time, the complexity of the overall component is increasing due to multitouch, haptic feedback, integrated camera technology and other sensor technology. Accordingly, the qualification techniques must be constantly adapted and expanded and face new challenges to be able to evaluate image processing measures and optimizations, e.g. through local dimming.Modern optical measurement techniques in combination with efficient and fully comprehensive commissioning of entire components can significantly shorten the development time and are today decisive competitive advantages. We show and try to evaluate which changes are necessary for the development process as well as for the product validation and give examples for corresponding solution approaches.The work was done in cooperation with the quality assurance department at Mercedes‐Benz AG.
65‐1: Invited Paper: Biaxially Formed LC Cells and Organic Transistors for 3D Curved Displays for Automotive Applications
Authors: Cain Paul , Russell Andrew , James Ashley , Wheeler May , Reeves William H 
Published: July 2024

Unsurprisingly, the FPD industry began life making flat display panels. In recent years curved displays have entered production, including TVs and foldable smartphone displays built on polyimide. These are manufactured in a flat state, then uniaxially curved.However, many real‐world surfaces have surfaces with biaxial curvature, either for aesthetic or functional reasons, and require biaxially curved displays with active optics that enable these surfaces to actively modulate, steer and focus light.We report on recent developments which show that flexible OTFT arrays, LC cells and Organic LCDs (OLCDs) can be biaxially thermoformed to spherically curved surfaces.
66‐1: Invited Paper: Display Performance Standards: Clearing up OEM and Consumer Confusion
Authors: Wooster Roland , Stolitzka Dale 
Published: July 2024

The PC display market has evolved rapidly in recent years, with new technologies and capabilities like high dynamic range (HDR), motion blur reduction and ultra‐high variable refresh rates being introduced at a rapid rate. However, when it comes to choosing a display, consumers are often at a disadvantage. How can they better understand the capabilities of each display, and trust the specs provided by the manufacturer? For display OEMs, having consistent, measurable display performance parameters around which to qualify and promote their products is also beneficial to product development and commercialization.For the past six years, the Video Electronics Standards Association (VESA) has released multiple front‐of‐screen performance standards to help consumers and OEMs meet these needs. This paper will review the compliance test specifications for several of these standards, including the newest update to VESA's HDR standard, DisplayHDR v1.2, which will be launched in the first half of 2024.
96‐1: Invited Paper: Flat Panel Haptics: Embedded Electroosmotic Pumps for Scalable Shape Displays
Authors: Shultz Craig , Mullenbach Joseph , Harrison Chris 
Published: July 2024

The flat, featureless nature of touch screen displays has meant keyboard text entry is slower and more error‐prone than on mechanical counterparts, and has also introduced negative side effects in demanding settings like automotive. Ideally, we could maintain the graphical flexibility afforded by displays, but carry over the tactile benefits of physical keyboard keys and buttons. Flat panel haptic displays have the potential to achieve this.We present a new type of shape‐changing display using embedded electroosmotic pumps (EEOPs). Our pumps are 1.5mm in thickness, and allow complete stack‐ups under 5mm with the opportunity to become much thinner. Our EEOPs can move their entire volume's worth of fluid in 1 second, and apply pressures of +/‐50kPa. This is enough to create dynamic, mm scale tactile features on a surface.
P‐107: High‐Resolution Periodic Patterning for Volume Manufacturing on +300mm Size Substrates Using Displacement Talbot Lithography
Authors: Wooley Kelsey , Solak Harun , Dais Christian , Clube Francis , Mohammad Ahmed , Bykova Iuliia , Lebugle Maxime , Seure Thibault , Heydari Mehdi , Wilson Matthew , Wang Li 
Published: July 2024

The photonic device market has a need for low‐cost, high‐resolution periodic patterning that scales with product maturity to large substrate sizes. Eulitha's DTL (Displacement Talbot Lithography) technology was limited to only a single exposure field per substrate on preexisting platforms which can fully pattern 100 and 150mm substrates. The new ‘PhableS' is Eulitha's step‐and‐repeat solution to bring all the advantages of the DTL patterning to larger substrates.The PhableS tool builds on Eulitha's patented displacement Talbot lithography technology to open the way for customers to fully scale to high volume production. This tool retains the strong technical performance; including 60nm half pitch resolution (DUV version), 140x140mm2 single shot exposure field, large depth of focus (hundreds of microns), high throughput (+40wph), non‐contact, mask‐based patterning. Automated wafer and mask handling support industry expected repeatability and defect‐free patterning.
When and how is depression associated with ostracism among college students? The mediating role of interpretation bias and the moderating role of awareness rather than acceptance
Authors: Chen Jing , Lin Xiaoxiao , Wang Ning , Wang Yuzheng , Wang Jinyan , Luo Fei 
Published: July 2024

AbstractDepression is closely related to individual social functions. The current study aimed to examine whether depression is associated with ostracism, whether interpretation bias mediates this relationship, and whether trait mindfulness moderates direct and indirect relationships between depression and ostracism. Overall, 389 Chinese college students completed the Center for Epidemiological Survey, Depression Scale, Interpretation Bias Questionnaire, Philadelphia mindfulness scale, and perceived ostracism scale at two‐time points. Latent Profile analysis and moderated mediation analysis were performed. After controlling for sex and age, depression (t1) was positively correlated to perceived ostracism, with this relationship being partially mediated by negative interpretation bias (IBN, t2). The effect of IBN on perceived ostracism was weak when awareness was high at time 2. Acceptance had a non‐significant moderating role in the relationship between IBN and perceived ostracism at time 2. LPA delineated three profiles: high awareness, high acceptance, and medium mindfulness. The moderating role of the different profiles in the relationship between IBN (t2) and perceived ostracism (t2) was significant. Depressed individuals appear to experience more ostracism because of IBN. Awareness might alleviate the effect of IBN on perceived ostracism.
Metabolic Labeling and Digital Microfluidic Single‐Cell Sequencing for Single Bacterial Genotypic‐Phenotypic Analysis
Authors: Guo Junnan , Sun Di , Li Kunjie , Dai Qi , Geng Shichen , Yang Yuanyuan , Mo Mengwu , Zhu Zhi , Shao Chen , Wang Wei , Song Jia , Yang Chaoyong , Zhang Huimin 
Published: July 2024

AbstractAccurate assessment of phenotypic and genotypic characteristics of bacteria can facilitate comprehensive cataloguing of all the resistance factors for better understanding of antibiotic resistance. However, current methods primarily focus on individual phenotypic or genotypic profiles across different colonies. Here, a Digital microfluidic‐based automated assay for whole‐genome sequencing of single‐antibiotic‐resistant bacteria is reported, enabling Genotypic and Phenotypic Analysis of antibiotic‐resistant strains (Digital‐GPA). Digital‐GPA can efficiently isolate and sequence antibiotic‐resistant bacteria illuminated by fluorescent D‐amino acid (FDAA)‐labeling, producing high‐quality single‐cell amplified genomes (SAGs). This enables identifications of both minor and major mutations, pinpointing substrains with distinctive resistance mechanisms. Digital‐GPA can directly process clinical samples to detect and sequence resistant pathogens without bacterial culture, subsequently provide genetic profiles of antibiotic susceptibility, promising to expedite the analysis of hard‐to‐culture or slow‐growing bacteria. Overall, Digital‐GPA opens a new avenue for antibiotic resistance analysis by providing accurate and comprehensive molecular profiles of antibiotic resistance at single‐cell resolution.
Application of data element mapping and analysis for system definition to enable model‐based systems engineering
Authors: Ledford Allison , Harris Gregory , Askew Susan , Purdy Gregory 
Published: July 2024

AbstractIn the connected age of the model‐based enterprise and model‐based systems engineering (MBSE), new systems engineering tools are needed to move from a functional, document‐centric, hierarchical view of data and information to the individual units of data or data element level view. Data element mapping and analysis (DEMA) is a technology‐agnostic analytical methodology that combines traditional functional analysis techniques, systems engineering elicitation practices, and novel data mapping techniques to provide a holistic view of a system's data and information flows at the individual units of data (data element level). In this research, DEMA was utilized to enable an enhanced system definition for the development of a verification and validation process as applied to a modeling and simulation environment. DEMA uncovered and visually mapped the hidden flow of approximately 1600 data vessel occurrences as inputs or outputs to 79 functional activities in 23 disparate storage locations. The results reveal that DEMA is a practical tool for both improving existing systems and defining new systems. The data element level view captured by DEMA can be used to define the interconnections between the system elements that are input to systems modeling language (SysML) models. Therefore, DEMA is a necessary and novel tool that can be used to enable system digitalization.