bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zonificación Hidrogeológica para el manejo de los recursos hídricos de la subcuenca Río Gil González, Rivas
Authors: Ruiz Álvarez Maynor , Flores Meza Yelba 
Published: July 2015

Se ha realizado la zonificación hidrogeológica para el manejo de los recursos hídricos de la subcuenca Rio Gil González, utilizando la superposición de evaluaciones: geológica, hidrológica e hidrogeológica. Se utilizaron los criterios geológicos, hidrogeológicos, tipo de suelos para definir cada una de las zonas, basadas en similaridad de propiedades hidráulicas del medio geológico. La subcuenca del Rio Gil González se localiza en el flanco Oeste del Lago Cocibolca, pertenece a la cuenca de los grandes Lagos Nicaragüenses y es compartida por los municipios de Belén, Potosí y Buenos Aires, con un área total de 68.43Km2. Geomorfológicamente se establecieron tres tipos de relieve montañoso, ondulado o colinas y valles, todos dominados por los tipos de rocas La geología está dominada por sedimentos cretácicos de la Formación Rivas y Sedimentos Cuaternarios, acumulados por erosión y deposición aluvial. Los tipos de suelos dominantes son suelos Alfisoles, Vertisoles y Entisoles dominantemente suelos arcilloso con una permeabilidad limitada. Se establecieron cuatro zonas hidrogeológicas; acuíferos aluviales, acuíferos fracturados, acuíferos intramontanos y esteros y humedales.DOI: http://dx.doi.org/10.5377/uyc.v6i9.1959 Revista Universidad y Ciencia. Año 2012 Vol. 6 No. 9. Julio – Diciembre; 37-53
Objectieve vergelijkbaarheid bij belastingvoordelen voor cultureel erfgoed: bouwt het Hof van Justitie luchtkastelen?
Authors: Phoa P.S. 
Published: July 2015

De centrale vraag in deze twee prejudiciële verwijzingen was of belanghebbenden, eigenaren van respectievelijk een kasteel in België en een landgoed in het Verenigd Koninkrijk, gebruik konden maken van Nederlandse belastingvoordelen voor het behoud van nationaal cultureel en natuurlijk erfgoed. De Nederlandse belastingautoriteiten meenden van niet, waarna in beroep de vraag is of dit een beperking vormt van het vrij verkeer van X en Q (de vrijheid van vestiging, respectievelijk het vrije kapitaalverkeer). Het Hof van Justitie was van oordeel dat geen sprake was van een ongeoorloofde inbreuk op het vrij verkeer, aangezien de situaties van X en Q niet objectief vergelijkbaar zijn met die van een ingezetene die een monument dan wel een landgoed in Nederland bezit.HvJ 18 december 2014, zaak C-87/13, Staatssecretaris van Financiën/X, ECLI:EU:C:2014:2459 HvJ 18 december 2014, zaak C-133/13, Staatssecretaris van Economische Zaken en Staatssecretaris van Financiën/Q, ECLI:EU:C:2014:2460
Prioritering en rechtsbescherming in het mededingingsrecht: de zaak easyJet
Authors: Gaasbeek P.B. 
Published: July 2015

In het arrest easyJet is de vraag aan de orde of en wanneer de Europese Commissie een zaak kan afwijzen omdat een nationale mededingingsautoriteit een prioriteringsbesluit heeft genomen. De uitspraak past in de lijn van arresten over Verordening (EG) nr. 1/2003 waarin veel ruimte wordt geboden aan de nationale autoriteiten en de Commissie om een doeltreffend decentraal stelsel voor toepassing van de mededingingsregels te garanderen. De vraag is of deze ruimte niet het onwenselijke gevolg heeft dat een klacht nergens daadwerkelijk wordt behandeld.Gerecht 21 januari 2015, zaak T-355/13, easyJet Airline Co. Ltd/Europese Commissie, ECLI:EU:T:2015:36
Right‐handed circularly polarized dispersive Alfvén wave: Localization and turbulence in solar wind
Authors: Sharma R. P. , Sharma Swati , Gaur Nidhi 
Published: July 2015

AbstractThe elucidation of the turbulent spectrum in the solar wind region in the dispersive range of scales is not yet completely established. The observational analysis of many spacecraft report that the fluctuations on the order of (or smaller scales) proton inertial length λi = c/ω p i show disparity with respect to the large‐scale fluctuations. We present a parallel‐propagating dispersive Alfvén wave that becomes dispersive as a result of the finite frequency of the wave, when subjected to transverse instability can be used to study the steepening in power spectrum around proton inertial length. The transverse density perturbations of acoustic wave can couple nonlinearly with parallel‐propagating pump and the driven ponderomotive force consecutively leads to growth of perturbations. We have studied the evolution of localized structures with time and the power spectral density when the system reaches quasi steady state. The application of the results in the solar wind turbulence is also discussed.
Plasma density undulations correlated with thermospheric neutral mass density in the daytime low‐latitude to midlatitude topside ionosphere
Authors: Park Jaeheung , Lühr Hermann , Nishioka Michi , Kwak Young‐Sil 
Published: July 2015

AbstractPlasma density undulations in the dayside low‐latitude/midlatitude ionospheric F region were often attributed to thermospheric gravity waves (TGWs). However, the relationship between the former and the latter has been at best indirectly evidenced. In this study we investigate daytime fluctuations in neutral mass density (ρ) and plasma density (ne) measured onboard CHAMP from 2001 to 2010. A significant amount of daytime fluctuations in ne is strongly correlated with in situ fluctuations of ρ, which we term “TGW‐related ne fluctuations.” The TGW‐related ne fluctuations are (1) stronger in the winter hemisphere than in the summer hemisphere and (2) strongest in the South American sector during June solstice months. These climatological features are in general agreement with those of TGWs reported previously, especially at midlatitudes. On the other hand, the relative amplitude of TGW‐related ne fluctuations does not depend strongly on solar activity.
Cooperatives’ Organizational Restructuring, Strategic Attributes, and Performance: The Case of Agribusiness Cooperatives in Greece
Authors: Benos Theo , Kalogeras Nikos , Verhees Frans J.H.M. , Sergaki Panagiota , Pennings Joost M.E. 
Published: July 2015

ABSTRACTWe develop a classification of traditional versus restructured cooperative organizational attributes based on an inductive approach. Using this classification and integrating concepts from the business literature (i.e., market and brand orientation), we hypothesize three types of relationships: (a) the influence of organizational attributes, i.e., ownership, control and cost/benefit allocation, on organizational performance; (b) the influence of strategic, i.e., market and brand orientation, attributes on organizational performance, and (c) the influence of organizational attributes on market orientation. We examine these relationships empirically in two studies. In study 1, using data from 114 agribusiness cooperatives, we demonstrate that strategic attributes have a greater influence on organizational performance than organizational attributes. In study 2, we replicate the design from study 1, i.e., tracking attribute scores over time, with a subsample of 25 cooperatives 4 years later. This second study generally confirms the findings of study 1. Taken together, the results suggest that greater emphasis should be placed on strategic attributes both in the literature and in practice.
Proportional recovery after stroke depends on corticomotor integrity
Authors: Byblow Winston D. , Stinear Cathy M. , Barber P. Alan , Petoe Matthew A. , Ackerley Suzanne J. 
Published: July 2015

ObjectiveFor most patients, resolution of upper limb impairment during the first 6 months poststroke is 70% of the maximum possible. We sought to identify candidate mechanisms of this proportional recovery. We hypothesized that proportional resolution of upper limb impairment depends on ipsilesional corticomotor pathway function, is mirrored by proportional recovery of excitability in this pathway, and is unaffected by upper limb therapy dose.MethodsUpper limb impairment was measured in 93 patients at 2, 6, 12, and 26 weeks after first‐ever ischemic stroke. Motor evoked potentials (MEPs) and motor threshold were recorded from extensor carpi radialis using transcranial magnetic stimulation, and fractional anisotropy (FA) in the posterior limbs of the internal capsules was determined with diffusion‐weighted magnetic resonance imaging.ResultsInitial impairment score, presence of MEPs and FA asymmetry were the only predictors of impairment resolution, indicating a key role for corticomotor tract function. By 12 weeks, upper limb impairment resolved by 70% in patients with MEPs regardless of their initial impairment, and ipsilesional rest motor threshold also resolved by 70%. Resolution of impairment was insensitive to upper limb therapy dose.InterpretationThese findings indicate that upper limb impairment resolves by 70% of the maximum possible, regardless of initial impairment, but only for patients with intact corticomotor function. Impairment resolution seems to reflect spontaneous neurobiological processes that involve the ipsilesional corticomotor pathway. A better understanding of these mechanisms could lead to interventions that increase resolution of impairment above 70%. Ann Neurol 2015;78:848–859
Time to endovascular reperfusion and degree of disability in acute stroke
Authors: Sheth Sunil A. , Jahan Reza , Gralla Jan , Pereira Vitor M. , Nogueira Raul G. , Levy Elad I. , Zaidat Osama O. , Saver Jeffrey L. ,   for the SWIFT‐STAR Trialists
Published: July 2015

ObjectiveFaster time from onset to recanalization (OTR) in acute ischemic stroke using endovascular therapy (ET) has been associated with better outcome. However, previous studies were based on less‐effective first‐generation devices, and analyzed only dichotomized disability outcomes, which may underestimate the full effect of treatment.MethodsIn the combined databases of the SWIFT and STAR trials, we identified patients treated with the Solitaire stent retriever with achievement of substantial reperfusion (Thrombolysis in Cerebral Infarction [TICI] 2b–3). Ordinal numbers needed to treat values were derived by populating joint outcome tables.ResultsAmong 202 patients treated with ET with TICI 2b to 3 reperfusion, mean age was 68 (±13), 62% were female, and median National Institutes of Health Stroke Scale (NIHSS) score was 17 (interquartile range [IQR]: 14–20). Day 90 modified Rankin Scale (mRS) outcomes for OTR time intervals ranging from 180 to 480 minutes showed substantial time‐related reductions in disability across the entire outcome range. Shorter OTR was associated with improved mean 90‐day mRS (1.4 vs. 2.4 vs. 3.3, for OTR groups of 124‐240 vs. 241‐360 vs. 361‐660 minutes; p < 0.001). The number of patients identified as benefitting from therapy with shorter OTR were 3‐fold (range, 1.5–4.7) higher on ordinal, compared with dichotomized analysis. For every 15‐minute acceleration of OTR, 34 per 1,000 treated patients had improved disability outcome.InterpretationAnalysis of disability over the entire outcome range demonstrates a marked effect of shorter time to reperfusion upon improved clinical outcome, substantially higher than binary metrics. For every 5‐minute delay in endovascular reperfusion, 1 of 100 patients has a worse disability outcome. Ann Neurol 2015;78:584–593
Crystallization kinetics of thermoplastic elastomeric blends based on ground tyre rubber
Authors: Lima Paulo S. , Oliveira José M. , Costa Vítor A. F. 
Published: July 2015

ABSTRACTThis work analyzes the crystallization process of thermoplastic elastomeric blends (TPE) based on ground tyre rubber (GTR). More specifically it analyzes the effect of GTR and fresh rubber materials, like ethylene propylene diene monomer (EPDM) and ethylene propylene rubber (EPR), on the crystallization of binary and ternary polypropylene (PP)‐based blends. The crystallization kinetics is studied under isothermal and nonisothermal conditions using differential scanning calorimetry (DSC). The kinetic parameters derived from the Avrami model are used to study the effect of temperature and rubber materials on the nucleation mechanism, the morphology of the crystalline structures, and the crystallization rate. Results reveal that GTR has a strong nucleating effect on PP and that its presence leads to higher crystallization rates. The EPDM presence has a slight effect on the PP crystallization process whereas EPR has no significant effect. From the DSC curves it is possible to detect an inverse relationship between temperature and the crystallization rate. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2015,132, 42589.
Drug‐loaded microparticles prepared by the one‐step deposition of calcium carbonate/alginate onto cotton fabrics
Authors: Wu Huan‐Ling , Hou Xiao‐Xiao , Branford‐White Christopher , Sun Xiao‐Zhu , Tao Lei , Um‐I‐Zahra Syeda , Zhu Li‐Min 
Published: July 2015

ABSTRACTCalcium carbonate (CaCO3)/alginate inorganic–organic hybrid particles were synthesized and deposited on to the surface of cotton fabrics with a novel one‐step procedure. The effects of the Ca2+/CO32−/alginate molar ratio on the cotton matrix were investigated. The optimization of the process resulted in a regular shaped hybrid microparticles, and scanning electron microscopy revealed that the particles were uniformly distributed on the surface of the fibers. Dynamic light scattering showed that the particles were about 2 μm in diameter. Moreover, transmission electron microscopy images demonstrated that the core–shell structure of the particles existed along with CaCO3 evenly enfolded into the alginate layer. An X‐ray diffraction pattern displayed that the alginate/CaCO3 hybrid microparticles were a mixture of calcite and vaterite crystal. Fourier transform infrared spectroscopy indicated that CaCO3/alginate hybrid particles formed in situ were the only deposited materials. The thermogravimetric analysis curve indicated a certain mass ratio of the alginate and CaCO3 in the hybrid particles. Furthermore, the drug‐loading and drug‐release properties of the hybrid microspheres were studied, and the results show that the water‐soluble diclofenac sodium could be effectively loaded in the hybrid microparticles and the drug release could be effectively sustained. Finally, both of the microparticles and modified fabrics had good cytocompatibility. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42618.
Prioritizing localized management actions for seagrass conservation and restoration using a species distribution model
Authors: Adams Matthew P. , Saunders Megan I. , Maxwell Paul S. , Tuazon Daniel , Roelfsema Chris M. , Callaghan David P. , Leon Javier , Grinham Alistair R. , O'Brien Katherine R. 
Published: July 2015

Abstract

Seagrass habitat is globally threatened from the cumulative impact of human activities on coastal ecosystems. Successful conservation and restoration of seagrass requires knowledge of the environmental factors that limit seagrass presence; however, quantifying the relative importance of these environmental factors is a significant challenge.
To resolve this issue, a species distribution model (SDM) for seagrass was constructed from a range of data collected at different spatial and temporal resolutions in Moreton Bay, Australia. Mean annual benthic light availability, significant wave height, and sediment settling time (calculated from sediment size distribution) were the environmental factors predicting seagrass presence in the model, which was calibrated and validated using maps of seagrass cover from 2004 and 2011, respectively.
The SDM correctly classified seagrass presence/absence in 85% of cases for calibration to 2004 data and 88% of cases for validation to 2011 data.
Application of the SDM to 12 regions of 10–100 km2 size within the study area demonstrated that the environmental factors limiting seagrass presence (i.e. either threatening seagrass that is present or hindering its colonization if seagrass is absent) varied substantially between these regions. For example, seagrass presence in the regions Waterloo Bay and Central West was predicted to be limited by their high mud content, while in the region Deception Bay South, light availability was the major limiting factor.
The results demonstrate that SDMs need to be developed on a sufficiently broad scale to capture significant variability in environmental conditions. These models can then be applied at finer scales to assess management options based on the local environmental conditions.
Copyright © 2015 John Wiley & Sons, Ltd.
Bayesian semiparametric analysis of recurrent failure time data using copulas
Authors: Meyer Renate , Romeo Jose S. 
Published: July 2015

The analysis of recurrent event data is of particular importance in medical statistics where patients suffering from chronic diseases often present with multiple recurring relapses or cancer patients experience several tumor recurrences. Whereas individual subjects can be assumed to be independent, the times between events of one subject are neither independent nor identically distributed. Apart from the marginal approach by Wei et al. (), the shared frailty model, see for example Duchateau and Janssen (), has been used extensively to analyze recurrent event data, where the correlation between sequential times is implicitly taken into account via a random effect. Oakes () and Romeo et al. () showed and exemplified the equivalence of frailty models for bivariate survival data to Archimedean copulas. Despite the fact that copula‐based models have been used to model parallel survival data, their application to recurrent failure time data has only recently been suggested by Lawless and Yilmaz () for the bivariate case. Here, we extend this to more than two recurrent events and model the joint distribution of recurrent events explicitly using parametric copulas within a Bayesian framework. This framework allows for parametric as well as a nonparametric modeling of the marginal baseline hazards and models the influence of covariates on the marginals via a proportional hazards assumption. Furthermore, the parameters of the copula may also depend on the covariates. We illustrate the flexibility of this approach using data from an asthma prevention trial in young children.
Glycoengineering of Chinese hamster ovary cells for enhanced erythropoietin N‐glycan branching and sialylation
Authors: Yin Bojiao , Gao Yuan , Chung Cheng‐yu , Yang Shuang , Blake Emily , Stuczynski Mark C. , Tang Juechun , Kildegaard Helene F. , Andersen Mikael R. , Zhang Hui , Betenbaugh Michael J. 
Published: July 2015

ABSTRACTSialic acid, a terminal residue on complex N‐glycans, and branching or antennarity can play key roles in both the biological activity and circulatory lifetime of recombinant glycoproteins of therapeutic interest. In order to examine the impact of glycosyltransferase expression on the N‐glycosylation of recombinant erythropoietin (rEPO), a human α2,6‐sialyltransferase (ST6Gal1) was expressed in Chinese hamster ovary (CHO‐K1) cells. Sialylation increased on both EPO and CHO cellular proteins as observed by SNA lectin analysis, and HPLC profiling revealed that the sialic acid content of total glycans on EPO increased by 26%. The increase in sialic acid content was further verified by detailed profiling of the N‐glycan structures using mass spectra (MS) analysis. In order to enhance antennarity/branching, UDP‐N‐acetylglucosamine: α‐1,3‐D‐mannoside β1,4‐N‐acetylglucosaminyltransferase (GnTIV/Mgat4) and UDP‐N‐acetylglucosamine:α‐1,6‐D‐mannoside β1,6‐N‐acetylglucosaminyltransferase (GnTV/Mgat5), was incorporated into CHO‐K1 together with ST6Gal1. Tri‐ and tetraantennary N‐glycans represented approximately 92% of the total N‐glycans on the resulting EPO as measured using MS analysis. Furthermore, sialic acid content of rEPO from these engineered cells was increased ∼45% higher with tetra‐sialylation accounting for ∼10% of total sugar chains compared to ∼3% for the wild‐type parental CHO‐K1. In this way, coordinated overexpression of these three glycosyltransferases for the first time in model CHO‐K1 cell lines provides a mean for enhancing both N‐glycan branching complexity and sialylation with opportunities to generate tailored complex N‐glycan structures on therapeutic glycoproteins in the future. Biotechnol. Bioeng. 2015;112: 2343–2351. © 2015 Wiley Periodicals, Inc.
Continuous downstream processing for high value biological products: A Review
Authors: Zydney Andrew L. 
Published: July 2015

ABSTRACTThere is growing interest in the possibility of developing truly continuous processes for the large‐scale production of high value biological products. Continuous processing has the potential to provide significant reductions in cost and facility size while improving product quality and facilitating the design of flexible multi‐product manufacturing facilities. This paper reviews the current state‐of‐the‐art in separations technology suitable for continuous downstream bioprocessing, focusing on unit operations that would be most appropriate for the production of secreted proteins like monoclonal antibodies. This includes cell separation/recycle from the perfusion bioreactor, initial product recovery (capture), product purification (polishing), and formulation. Of particular importance are the available options, and alternatives, for continuous chromatographic separations. Although there are still significant challenges in developing integrated continuous bioprocesses, recent technological advances have provided process developers with a number of attractive options for development of truly continuous bioprocessing operations. Biotechnol. Bioeng. 2016;113: 465–475. © 2015 Wiley Periodicals, Inc.
Continuous cyclohexane oxidation to cyclohexanol using a novel cytochrome P450 monooxygenase from Acidovorax sp. CHX100 in recombinant P. taiwanensis VLB120 biofilms
Authors: Karande Rohan , Debor Linde , Salamanca Diego , Bogdahn Fabian , Engesser Karl‐Heinrich , Buehler Katja , Schmid Andreas 
Published: July 2015

ABSTRACTThe applications of biocatalysts in chemical industries are characterized by activity, selectivity, and stability. One key strategy to achieve high biocatalytic activity is the identification of novel enzymes with kinetics optimized for organic synthesis by Nature. The isolation of novel cytochrome P450 monooxygenase genes from Acidovorax sp. CHX100 and their functional expression in recombinant Pseudomonas taiwanensis VLB120 enabled efficient oxidation of cyclohexane to cyclohexanol. Although initial resting cell activities of 20 U gCDW−1 were achieved, the rapid decrease in catalytic activity due to the toxicity of cyclohexane prevented synthetic applications. Cyclohexane toxicity was reduced and cellular activities stabilized over the reaction time by delivering the toxic substrate through the vapor phase and by balancing the aqueous phase mass transfer with the cellular conversion rate. The potential of this novel CYP enzyme was exploited by transferring the shake flask reaction to an aqueous‐air segmented flow biofilm membrane reactor for maximizing productivity. Cyclohexane was continuously delivered via the silicone membrane. This ensured lower reactant toxicity and continuous product formation at an average volumetric productivity of 0.4 g Ltube−1 h−1 for several days. This highlights the potential of combining a powerful catalyst with a beneficial reactor design to overcome critical issues of cyclohexane oxidation to cyclohexanol. It opens new opportunities for biocatalytic transformations of compounds which are toxic, volatile, and have low solubility in water. Biotechnol. Bioeng. 2016;113: 52–61. © 2015 Wiley Periodicals, Inc.