bluuebunny/crossref_metadata_2025_split huggingface dataset:
The possibilities of the cardiorespiratory test in evaluation the level of physical capacity and prognosis in pediatric patients with congenital heart diseases (literature review)
Authors: Yakovleva E. V. , Berezina A. V. , Korshikova Yu. V. , Vershinina T. L. , Pervunina T. M. , Demchenko E. A. , Starshinova A. A. , Vasichkina E. S. 
Published: August 2024

Congenital heart defects (CHD) are the most common form of congenital malformations in children. Due to early diagnosis, rapid development of cardiac surgery technologies as well as successes in the care of severe patients after surgical correction of CHD, the survival and life expectancy of patients with CHD have significantly increased over the past decades. All this has led to the emergence of new population of patients with severe CHD and unique cardiac hemodynamics due to palliative intervention or multi-stage correction with large amount of exposure. Such patients have specific functional capabilities, special cardiopulmonary performance as well as the risk of serious adverse events (heart failure, life-threatening cardiac arrhythmias, sudden cardiac death and others).The review presents generalized current understanding about the possibilities of a cardiorespiratory test in children with various CHD.
Penanaman Karakter Disiplin di Lingkungan Ramah Anak
Authors: Khairunnisa Ulfadhilah  
Published: August 2024

Peran guru disekolah sangat berpengaruh pada karakter anak didik saat dilingkungan sekolah dengan memberikan tauladan maupun contoh sehingga anak dapat menirukan ataupun menerapkan saat disekolah, dan dirumah. Mendidik anak melakukan bertahap dengan telaten oleh guru dalam hal menanaman karakter disiplin pada anak saat disekolah dengan selalu menerapkan hal disiplin dengan hal-hal yang kecil, dan sederhana sehingga anak melihat kemudian akan terekam dalam otak usia dini fase emas yang tentunya sangat baik diberikan stimulasi yang tepat. Selain itu, lingkungan ramah anak di TKIT Al-Umm Cirebon sangat nyaman saat anak bermain dan lingkungan sekolah yang bersih maupun aman. Metode yang dilakukan yakni deskriptif kualitatif untuk menjelaskan hasil riset yang dilakukan oleh peneliti gunakan observasi, wawancara dengan guru TKIT Al-Umm Cirebon kemudian penulis melakukan dokumentasi untuk menguatkan hasil riset yang telah dilakukan. Hasil riset di TKIT Al-Umm Cirebon yakni anak didik mulai menerapkan disiplin saat disekolah ataupun saat dirumah dengan ditambah fasilitas sekolah yang memberikan suasana lingkungan ramah anak, dan aman untuk anak didik.
Penerapan Modifikasi Matras Menggunakan Media Serabut Kelapa untuk Meningkatkan Kemampuan Gerak Senam Lantai di MA Al-Muhajirin Tugumulyo
Authors: Permadani Heldian , Charli Leo , Remora Hengky 
Published: August 2024

Penelitian ini bertujuan untuk mengetahui apakah penerapan modifikasi matras menggunakan media serabut kelapa untuk mengingkatkan kemampuan gerak senam lantai siswa di MA AL-Muhajirin Tugumulyo tahun 2023. Adapun desain penelitian ini menggunakan desain one grup pretest dan posttest design. Populasi dan sampel menggunakan keseluruhan total siswa kelas XI IPS 2 di MA AL-Muhajirin Tugumulyo dengan jumlah 28 orang siswa. Teknik pengumpulan data yaitu menggunakan teknis tes. Teknik analisis data memakai data kuantitatif dengan menggunakan uji hipotesis paired T test. Hasil penelitian ini menunjukkan bahwa penerapan modifikasi matras menggunakan media serabut kelapa efektif dilakukan karna dapat memberi pengaruh yang signifikan terhadapa kemampuan gerak senam lantai siswa kelas XI IPS 2 di MA AL-Muhajirin Tugumulyo dengan rata-rata nilai kemampuan gerak senam lantai siswa pretest sebesar 69.1786 dan posttest sebesar 73.3214 dengan hasil data > yaitu 14.082 > 1,703 dengan nilai signifikan p sebesar 0,000 < 0,05. Kesimpulan dalam penelitian ini adalah penerapan modifikasi matras menggunkan media serabut kelapa dapat membantu meningkatkan kemampuan gerak senam lantai siswa kelas XI IPS 2 di MA AL-Muhajirin Tugumulyo.
Studi Kualitatif tentang Pola Konsumsi pada Ibu Hamil Kekurangan Energi Kronis di Desa Batuputih Laok
Authors: Fadzilah Rochmanita Ilvanadewi , Yuliatik Ita , Puspikawati Septa Indra , Mahiroh Hodimatum 
Published: August 2024

Latar Belakang: Kurang Energi Kronis (KEK) merupakan sebuah permasalahn gizi yang sering terjadi kepada wanita hamil dikarenakan kekurangan energi kronik dalam jangka waktu yang lama. Kekurangan Energi Kronik (KEK) pada negara berkembang adalah hasil komulatif dari suatu keadaan kurang gizi sejak pada masa janin, bayi, serta masa kanak-kanak yang dapat berlanjut hingga dewasa. Ibu hamil dengan KEK berisiko untuk melahirkan bayi dengan Berat Badan Lahir Rendah.
Tujuan: Dalam Penelitian ini memiliki tujuan untuk menganalisis penyebab Kekurangan Energi Kronis (KEK) pada ibu hamil di Desa Batuputih Laok.
Metode: Penelitian ini merupakan penelitian kualitatif dengan rancangan penelitian deskriptif melalui pendekatan fenomenologi. Subyek penelitian diambil secara purposive. Subjek penelitian adalah ibu hamil KEK dengan anemia di Desa Batuputih Laok sebagai informan kunci dengan jumlah 6 orang.
Hasil: Informan memiliki rentang usia 20-29 tahun dengan pendidikan SD, SMA, dan D3. Seluruh informan mengalami anemia dan LILA <23,5 cm sehingga termasuk KEK. Selain itu, hasil indepth interview menunjukkan bahwa ibu hamil tidak mau mengkonsumsi makanan dengan gizi seimbang selama masa kehamilannya. Selain itu, ibu hamil tidak mengonsumsi ikan dan protein lainnya karena tidak suka bau amisnya serta ada pantangan untuk konsumsi ikan. Beberapa informan dalam sehari terkadang hanya makan satu kali meskipun dalam kondisi hamil. Informan tidak meminum Fe karena tidak suka minum obat, selain itu terdapat informan yang tidak meminum Fe selama hamil lima bulan dikarenakan mual-mual.
Kesimpulan: KEK pada ibu hamil disebabkan oleh pola konsumsi tidak mau konsumsi makanan tinggi protein, adanya pantangan dari orangtua, menu makanan yang tidak beragam, porsi makan kurang dari kebutuhan kalori, frekuensi makan yang kurang, serta tidak minum Fe. Oleh karena itu, perlu adanya penyuluhan serta konseling gizi kepada ibu hamil untuk dapat meningkatkan pengetahuan tentang pentingnya gizi seimbang bagi ibu hamil serta meluruskan kekeliruan tentang pantangan makan.
Hubungan Lingkar Lengan Atas (LILA) pada Ibu Hamil dengan Kejadian Berat Badan Lahir Rendah (BBLR): Systematic Review
Authors: Nisak Siti Khoirotun , Nadhiroh Siti Rahayu 
Published: August 2024

Latar Belakang: Indonesia tercatat mempunyai fenomena yang cukup tinggi atas kematian ibu dan bayi dibanding pada negara berkembang lainnya. Jumlah kematian bayi baru lahir pada tahun 2015 sebanyak 33.278 kasus, turun dari 32.007 kasus pada tahun 2015 dan sebanyak 10.294 kasus pada triwulan I tahun 2017. Kasus BBLR (Berat Badan Lahir Rendah) menjadi salah satu variabel yang mendorong terjadinya kematian pada bayi, sebanyak 38,5% kasus terjadi di Indonesia. Bayi mengalami BBLR apabila berat badan ketika lahir tidak mencapai 2.500 gram. Terjadinya BBLR dapat dikontrol oleh kondisi gizi dari ibu hamil. Status gizi ibu pada risiko kasus BBLR dapat diukur menggunakan antropometri yaitu Lingkar Lengan Atas (LILA) serta Indeks Massa Tubuh (IMT). Ibu hamil memiliki resiko yang tinggi apabila angka LILA<23,5 cm dan IMT <18.
Tujuan: Studi literatur ini lakukan untuk menganalisis pengaruh Lingkar Lengan Atas (LILA) ibu hamil terhadap risiko BBLR.
Metode: Penulisan artikel ini menggunaka metode systematic review. Sumber data dari artikel di didapatkan dari artikel literatur Science Direct, PubMed, Google Scholar dan didapatkan 10 artikel yang relevan. Artikel di batasi hanya penelitian original yang digunakan dengan tahun terbit 2017 sampai 2022.
Hasil: Terpapar penyakit infeksi dan penyakit non infeksi dapat memperburuk efek malnutrisi ibu hamil dan janin yang dikandungnya sehingga memberikan dampak pada terjadinya BBLR, ibu yang mempunyai LILA≤ 23, 5 cm dapat mengalmai KEK (Kekurangan Energi Kronis) sehingga dapat melahirkan bayi dengan BBLR ,BBLR juga menyebabkan risiko meninggal yang lebih besar yaitu 20 kali dibanding pada kelahiran bayi dengan berat badan ideal.
Kesimpulan: Tinjauan ini menyimpulkan bahwa LILA ibu hamil memiliki hubungan yang kuat dengan masalah BBLR.
Ferromagnetism and correlated insulating states in monolayer Mo33Te56
Authors: Pan Zemin , xiong wenqi , Dai Jiaqi , Zhang Hui , Wang Yunhua , Jian Tao , Cui Xingxia , Deng Jinghao , Lin Xiaoyu , Cheng Zhengbo , Bai Yusong , Zhu Chao , Huo Da , Li Geng , Feng Min , He Jun , Ji Wei , Yuan Shengjun , Wu Fengcheng , Zhang Chendong , Gao Hong-Jun 
Published: August 2024

Abstract

Although the kagome model is fundamentally two-dimensional, the essential kagome physics, i.e., the kagome-bands-driven emergent electronic states, has yet to be explored in the monolayer limit. Here, we present the experimental realization of kagome physics in monolayer Mo33Te56, showcasing both ferromagnetic ordering and a correlated insulating state with an energy gap of up to 15 meV. This finding is facilitated by an unprecedented structural phase of monolayer Mo-Te compound, which forms a mirror-twin boundary loop superlattice exhibiting kagome geometry and multiple sets of kagome bands, as elucidated by scanning tunnelling microscopy (STM) and theoretical calculations. The partial occupancy of these nearly flat bands results in Fermi surface instability, counteracted by the emergence of ferromagnetic order (with a coercive field ~0.1 T, as observed by spin-polarized STM) and the opening of a correlated hard gap. Our work establishes a robust framework featuring well-defined atomic and band structures, alongside the intrinsic two-dimensional nature, essential for the rigorous examination of kagome physics.
WITHDRAWN: Factors influencing the acceptance of wrist-worn wearable devices by the elderly in China
Authors: Cai Min , Zhao Yanling , Wu Miaohuan , Luo Xinggang 
Published: August 2024

Abstract

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
A Combinatorial Approach Towards Ramanujan's Partition Congruences Modulo 5, 7 and 11 In Terms Of Its Corresponding Cranks
Authors: De Subham 
Published: August 2024

Abstract

The primary purpose of this article is to provide an explicit interpretation of \textit{Ramanujan}'s Partition Congruences, namely, $p(5n+4)\equiv 0\mbox{ }(mod\mbox{ }5)$, $p(7n+5)\equiv 0\mbox{ }(mod\mbox{ }7)$ and, $p(11n+6)\equiv 0\mbox{ }(mod\mbox{ }11)$, $p(n)$ being the \textit{partition function} corresponding to any positive integer $n$, in terms of their corresponding \textit{Cranks} using various combinatorial arguments implemented by \textit{Dyson}, \textit{Atkin}, \textit{Swinnerton-Dyer} and later by \textit{Andrews} and, \textit{Garvan} to justify all the necessary concepts pertaining to this topic.

2020 MSC: Primary 11-02, 11P81, 11P82, 11P83, 11P84. Secondary 11B75, 05A16, 05A17, 05A30.
Magnetic resonance imaging-based quantification of endosomal escape using iron oxide nanoparticles-loaded lipid nanoparticles
Authors: Im Hyung-Jun , Park Jeongbin , Lee Somin , Jung Han Na , Li Shengjun , Lee Woojin 
Published: August 2024

Abstract

Lipid nanoparticles (LNPs) have attracted attention as a promising and advanced platform for the delivery of nucleic acid-based therapeutics. The therapeutic efficacy of LNP-based drugs depends heavily on endosomal escape. However, few methods are available for quantifying the efficiency of endosomal escape. In this study, we developed a novel method to quantify the endosomal escape efficiency using magnetic resonance imaging (MRI). We synthesized ultrasmall iron oxide nanoparticles (IONPs) and incorporated them into LNPs to produce IO@LNPs. After cells internalized the IO@LNPs, we observed a decline in the R2 relaxation over time, suggesting that free IONPs were dispersed due to endosomal escape. Biological electron microscopy further corroborated this finding, showing a strong correlation between the R2 relaxation and the number of intracellular vesicles harboring the intact IO@LNPs. Furthermore, in-vivo MRI experiments in mice demonstrated an initial drop and a gradual increase in the T2 signal at the tissue site where IO@LNPs were injected, indicating the potential for in-vivo application of our method. Our findings could lead to advancements in LNP-based nucleic acid delivery by enhancing the understanding of endosomal escape dynamics.
Enhancing hatchery production efficiency for commercial offshore cultivation of giant kelp (macrocystis pyrifera) in Luderitz, Namibia
Authors: Andreas Hilinganye A. , Fleischman Michael J. , Iitembu Johannes A. 
Published: August 2024

Abstract

Macrocystis pyrifera is a potential candidate for aquaculture because it grows rapidly, forms extensive underwater forests, and yields substantial biomass; and was the focus of this study. This study assessed sporophyte production by gametophytes of M. pyrifera obtained from three populations: California (CAL), South Africa (CAT), and the Falkland Islands (FL) in relation to environmental parameters. Factors examined included temperature (7.5, 10 - control, 12.5°C), irradiance (22.5, 30 - control, 37.5 µmol m⁻² s⁻¹), and gametophyte stocking densities (0.085, 0.114 - control, 0.142 mg cm⁻²). The data collected were the time required for sporophyte generation at weekly intervals and the quantities of sporophytes produced per cm2. results indicated that a temperature of 12.5°C accelerated sporophyte production across all populations, with outputs of 126.03 (± 101.44) in CAL, 694.44 (± 244.46) in CAT and 1265.42 (± 448.30) in FL. At 7.5°C, no viable sporophyte production was observed for either CAL or CAT, whereas for FL, an increase in sporophyte quantities was observed (2142.49 (± 736.44)). In FL, reduced irradiance (22.5 µmol·m⁻².s⁻¹) resulted in increased sporophytes outputs (1705.25 (± 657.28)), while the control irradiance (30 µmol·m⁻². s⁻¹) was optimal for CAL 259.26 (± 203.16) and CAT 1970.16 (± 888.01). Gametophyte stocking density yielded the highest sporophyte outputs in CAT (1898.15 (± 534.67)) and FL (749.42 (± 359.09)) at the control treatment, while no differences were recorded for CAL between all density treatments. This study revealed that the optimization of sporophyte production through parameter manipulation enhances efficiency, and future research can explore increased lab temperature and its impact on sea recruitment rates.
Facilitators’ perspective towards implementation of Competency Based Medical Education (CBME) in a Government Medical College in Delhi: a cross-sectional study.
Authors: Dhandapani Ghurumourthy , Kumar Sanjeev , Gupta Sunanda , Lukhmana Shveta 
Published: August 2024

Abstract

Introduction
Competency-Based Medical Education (CBME) has emerged as a transformative approach to medical education worldwide over past few years. It focuses on the overall development of trainee physicians for ultimate provision of effective and safe patient care. In India, it was an anticipated change in medical education. It got implemented in 2019.
Methods
A cross-sectional study was conducted among 127 faculty members of Vardhman Mahavir Medical College an Safdarjung hospital, New Delhi in July 2022, with a validated self-developed questionnaire (Cronbach alpha 0.85) to evaluate facilitators perspective about the recently rolled out CBME and perceived challenges for implementing CBME in a medical college of Delhi.
Results
The median age of faculty members were 42 years with median teaching experience of ten years. Ninety-one percent faculty members aware of CBME and 88% felt that it was better than old medical curriculum. Integrated teaching (62%) and early clinical exposure (55%) were the most the common perceived benefits of CBME. Ninety-three percent and eighty-five percent of faculty members felt that infrastructural deficit and time and priorities were major barriers for implementation of CBME, respectively.
Conclusion
National medical commission (NMC) should guide for sufficient infrastructure and ensure periodical training to faculty members.
Unexplained emphysema of scrotum and thigh after direct anterior approach total hip arthroplasty
Authors: Gong Zhangfan , Luo Xiongjunjie , Tan Congcong , Weng Lian , Yin Yiran 
Published: August 2024

Abstract

Background Direct anterior approach(DAA) for total hip arthroplasty (THA), which has the characteristics of less trauma, quick recovery and low risk of early dislocation, is a popular surgical procedure for osteonecrosis of the femoral head. Common early complications of DAA total hip arthroplasty include the injury of lateral femoral cutaneous nerve, deep vein thrombosis, poor incision healing and unequal length of legs, etc. Emphysema of scrotum and thigh is very rare and there is no report about it occurred after DAA total hip arthroplasty.Case presentation: This is the first report about emphysema of scrotum and thigh after DAA total hip arthroplasty. A 55-year-old man with osteonecrosis of the left femoral head suffered unexplained emphysema of scrotum and the left thigh after DAA total hip arthroplasty. On the second day after operation, the patient complained of swelling and pain in his left thigh and swelling in the scrotum. The ultrasound examination of the scrotum indicated subcutaneous emphysema of the scrotum. The computed tomography scan and the ultrasound examination of the left thigh revealed pneumoderm and air in the intramuscular spaces. we gave the patient symptomatic treatment to ease pain and improve blood circulation, but we did not obtain a obvious curative effect. On the ninth postoperative day, the swelling of the patient’s left thigh and the scrotum partially relieved and he was discharged. The patient recovered well at one month and one year follow-up.Conclusion We firstly report a rare complication of emphysema of scrotum and thigh after direct anterior approach total hip arthroplasty in order to recommend it to orthopedists and attach their attention. We did not find the exact cause of this rare complication and hope to discuss the potential causes with all colleagues at the same time.
Overexpression of tlr5 affects gut microbiota resistance to Salmonella infection
Authors: Lei Chen , Wang Yue , Jiang Lijing , Zhang Lu , Tang Weiyi , Li Zhi , Zhao Xu , Li Xiang 
Published: August 2024

Abstract

Background
The gut microbiome and the host immune system interact synergistically to maintain intestinal health and defend against infections. Toll-like receptor 5 (TLR5), known for recognizing bacterial flagellin, plays a pivotal role in this regulatory network. Despite significant advances in understanding the gut microbiome and TLR5, the precise role of TLR5 in gut health and infection resistance remains unclear. This study aimed to elucidate the role of TLR5 in regulating gut microbiota and metabolites and their impact on resistance to Salmonella infection using a TLR5 intestinal-specific overexpression mouse model.
Methods
Fecal microbiota and metabolite transplantation experiments were conducted using feces from TLR5-overexpressing mice (TLR5+/+ group) and wild-type mice (WT group) into C57 mice, creating four experimental groups: Flora-TLR5-C57, Metabolite-TLR5-C57, Flora-WT-C57, and Metabolite-WT-C57. Mice were infected with Salmonella, and various parameters including survival time, fecal Salmonella load, and alterations in gut microbiota and metabolites were assessed.
Results
Despite notable shifts in gut microbiota composition and metabolite profiles induced by TLR5 overexpression, no significant differences in fecal Salmonella load or survival time were observed across the experimental groups. TLR5-overexpressing mice exhibited an enrichment of beneficial bacterial taxa and significant changes in metabolites; however, these alterations did not correlate with enhanced resistance to Salmonella infection.
Conclusion
Our findings suggest that while TLR5 overexpression significantly modifies gut microbiota and metabolite profiles, these changes do not directly enhance resistance to Salmonella infection. The immune response to Salmonella is multifaceted and involves various components beyond the gut microbiota and metabolites. Further research is required to elucidate the detailed molecular pathways through which TLR5 influences infection outcomes and to explore potential combined therapeutic strategies for enhancing host defenses against enteric pathogens.
Determination of Cryptococcal Antigen in Newly Diagnosed HIV Infected Patients Attending Specialist Hospital Sokoto North- Western Nigeria
Authors: Usman Abubakar Babangida , Yau Yassar Muhammad , Ibrahim Adamu Muhammad , Folashade Salaudeen Zainab , Abdullahi Hamisu , Hamid Kabir Magaji 
Published: August 2024

Abstract

Cryptococcosis is a common infectious disease that contributes significantly to death in HIV/AIDS patients. The aim of this study was to determine the prevalence of cryptococcal antigen among newly diagnosed HIV infected patients with CD4 count below 200µL attending antiretroviral clinic in specialist hospital Sokoto.. A descriptive cross-sectional study was carried out in the HIV clinic of the Sokoto Specialist Hospital. The participants were newly diagnosed HIV positive patients recruited through thorough random sampling. The sociodemographic and clinical characteristics of the subjects were recorded. Blood was obtained from the subjects to determine their CD4 level and the presence of cryptococcosis. Their CD4 levels were measured using the Visitect CD4 Advanced Disease Kit, and the presence of cryptococcal antigen in the blood sample was discovered using the CrAg LFA. Statistical analysis was performed using SPSS version 25.0. Univariate, bivariate, and multivariate analyses were completed. Out of the 154 HIV-positive patients recruited, 55 had CD4 count below 200µL (prevalence of 35.7%), 21 were positive to cryptococcal antigen (prevalence of 38.2%), and cryptococcal antigen and HIV co-infection was high among married couples (prevalence of 61.9%) and the age group of 31–40 (prevalence of 47.6%). The socioeconomic distribution of the co-infection showed that it was high among Hausa/Fulani, business owners, and informally educated people. This study reveals that cryptococcosis is a burden among HIV patients in Sokoto, and its frequency is linked to lower CD4 levels.