bluuebunny/crossref_metadata_2025_split huggingface dataset:
Second‐Generation Fluorescent Quadracyclic Adenine Analogues: Environment‐Responsive Probes with Enhanced Brightness
Authors: Dumat Blaise , Bood Mattias , Wranne Moa S. , Lawson Christopher P. , Larsen Anders Foller , Preus Søren , Streling Jens , Gradén Henrik , Wellner Eric , Grøtli Morten , Wilhelmsson L. Marcus 
Published: January 2015

AbstractFluorescent base analogues comprise a group of increasingly important molecules for the investigation of nucleic acid structure, dynamics, and interactions with other molecules. Herein, we report on the quantum chemical calculation aided design, synthesis, and characterization of four new putative quadracyclic adenine analogues. The compounds were efficiently synthesized from a common intermediate through a two‐step pathway with the Suzuki–Miyaura coupling as the key step. Two of the compounds, qAN1 and qAN4, display brightnesses (εΦF) of 1700 and 2300, respectively, in water and behave as wavelength‐ratiometric pH probes under acidic conditions. The other two, qAN2 and qAN3, display lower brightnesses but exhibit polarity‐sensitive dual‐band emissions that could prove useful to investigate DNA structural changes induced by DNA–protein or –drug interactions. The four qANs are very promising microenvironment‐sensitive fluorescent adenine analogues that display considerable brightness for such compounds.
Lowering the Reduction Potential of a Boron Compound by Means of the Substituent Effect of the Boryl Group: One‐Electron Reduction of an Unsymmetrical Diborane(4)
Authors: Asakawa Hiroki , Lee Ka‐Ho , Furukawa Ko , Lin Zhenyang , Yamashita Makoto 
Published: January 2015

AbstractWe have clarified and observed the high electron affinity of pinBBMes2 (1; Mes=mesityl, pin=pinacolato). By using electrochemistry, it was shown that 1 has a higher electron affinity than those of B2pin2 and Mes3B. One‐electron reduction of 1 gave the corresponding radical anion. The ESR spectroscopy and DFT calculation revealed the unsymmetrical distribution of electron density over the BB bond. UV/Vis spectroscopy showed that the SOMO‐related absorption supports the deep purple color of the radical anion. DFT studies on the torsion angle dependency of the LUMO levels and relative energies revealed the reason why 1 has high electron affinity as a result of the substituent effect of the Bpin group.
ChemInform Abstract: Zero Thermal Expansion and Ferromagnetism in Cubic Sc1‐xMxF3 (M: Ga, Fe) over a Wide Temperature Range.
Authors: Hu Lei , Chen Jun , Fan Longlong , Ren Yang , Rong Yangchun , Pan Zhao , Deng Jinxia , Yu Ranbo , Xing Xianran 
Published: January 2015

AbstractThe compounds ScF3, (Sc0.95Ga0.05)F3, (Sc0.9Ga0.05Fe0.05)F3, (Sc0.85Ga0.05Fe0.1)F3, and (Sc0.8Ga0.05Fe0.15)F3 are prepared by solid state reaction of Sc2O3, Fe2O3, Ga2O3, and NH4F (Pt crucible, 600 °C, 5h).
ChemInform Abstract: Hydrothermal Synthesis of Hollow Ca2Ge7O16 Microspheres as High‐Capacity Anodes for Li‐Ion Batteries with Long Cycling Life.
Authors: Lv Ting , Li Xiu , Ma Jianmin 
Published: January 2015

AbstractUrchin‐like Ca2Ge7O16 spheres are hydrothermally synthesized from aqueous mixtures of GeO2, CaCl2, and N‐methyl urea (autoclave, 240 °C, 12 h), and characterized by XRD, SEM, TEM, and electrochemical measurements.
ChemInform Abstract: Simultaneous Removal of Nitrite and Ammonia as Dinitrogen in Aqueous Suspensions of a Titanium(IV) Oxide Photocatalyst under Reagent‐Free and Metal‐Free Conditions at Room Temperature.
Authors: Kominami Hiroshi , Kitsui Ken , Ishiyama Yuki , Hashimoto Keiji 
Published: January 2015

AbstractPhotocatalytic reduction of nitrite in an aqueous suspension of TiO2 in the presence of ammonia results in the formation of N2 under irradiation of UV light at room temperature.
ChemInform Abstract: New RMnO3+δ (R: Y, Ho; δ ≈ 0.35) Phases with Modulated Structure.
Authors: Parkkima Outi , Malo Sylvie , Hervieu Maryvonne , Rautama Eeva‐Leena , Karppinen Maarit 
Published: January 2015

AbstractA series of hexagonal LnMnO3 compounds (Ln: Y, Ho—Lu) are prepared by sol‐gel synthesis using citric acid, Ln2O3, and Mn(NO3)2 in diluted HNO3 (300 °C, 12 h).
ChemInform Abstract: Ring‐Opening and ‐Expansion of 2,2′‐Biaziridine: Access to Diverse Enantiopure Linear and Bicyclic Vicinal Diamines.
Authors: Bailey Stephen J. , Wales Steven M. , Willis Anthony C. , Keller Paul A. 
Published: January 2015

AbstractStarting with the ring opening of enantiopure biaziridine (I) or its enantiomer (XV) with a range of nucleophiles functionalized vicinal diamines are produced, which are used in different cyclization steps to yield a variety of symmetric bicyclic diamines.
ChemInform Abstract: Ruthenium Complexes of Tetradentate Bipyridine Ligands: Highly Efficient Catalysts for the Hydrogenation of Carboxylic Esters and Lactones.
Authors: Li Wei , Xie Jian‐Hua , Yuan Ming‐Lei , Zhou Qi‐Lin 
Published: January 2015

AbstractA new type of readily available, air‐stable Ru‐complex is described.
ChemInform Abstract: Facile Regio‐ and Stereoselective Metal‐Free Synthesis of All‐Carbon Tetrasubstituted Alkenes Bearing a C(sp3)—F Unit via Dehydroxyfluorination of Morita—Baylis—Hillman (MBH) Adducts.
Authors: Takizawa Shinobu , Arteaga Fernando Arteaga , Kishi Kenta , Hirata Shuichi , Sasai Hiroaki 
Published: January 2015

AbstractStarting from easily accessible Baylis—Hillman adducts the synthesis of alkenes having four different C‐substituents including a challenging ‐CH2F is presented.
ChemInform Abstract: Activation of Alcohols with Carbon Dioxide: Intermolecular Allylation of Weakly Acidic Pronucleophiles.
Authors: Lang Simon B. , Locascio Theresa M. , Tunge Jon A. 
Published: January 2015

AbstractAn efficient method is developed for the direct coupling of allyl alcohols with nitriles, aldehydes, and nitroalkanes.
ChemInform Abstract: Photocatalytic Decarboxylative Reduction of Carboxylic Acids and Its Application in Asymmetric Synthesis.
Authors: Cassani Carlo , Bergonzini Giulia , Wallentin Carl‐Johan 
Published: January 2015

AbstractThe decarboxylative reduction of α‐amino acids and α‐hydroxy acids is achieved in the presence of the (mesityl)methylacridinium photoredox catalyst in combination with bis(4‐chlorophenyl) disulfide.
ChemInform Abstract: Benzoic Acid‐Catalyzed Transamidation Reactions of Carboxamides, Phthalimide, Ureas and Thioamide with Amines.
Authors: Wu Ji‐Wei , Wu Ya‐Dong , Dai Jian‐Jun , Xu Hua‐Jian 
Published: January 2015

AbstractThe method works best for the transamidation of primary amides.
ChemInform Abstract: Enaminones via Ruthenium‐Catalyzed Coupling of Thioamides and α‐Diazocarbonyl Compounds.
Authors: Hussaini Syed R. , et al. et al. 
Published: January 2015

AbstractThe use of Ru(II) catalysts, which are less expensive than the established Rh2(OAc)4, for the synthesis of enaminones via coupling of α‐diazocarbonyl compounds with thioamides is described.
ChemInform Abstract: The First Allylation of Esters by an Allylsilane: One‐Pot Domino Synthesis of Triallylmethane Derivatives.
Authors: Bandi Chenna Kesava Reddy , Belostotskii Anatoly , Hassner Alfred 
Published: January 2015

AbstractThe 2,6‐dimethoxyphenyl ester group usually gives the best results in the title reaction.
ChemInform Abstract: Formal C—H‐Azidation‐Based Shortcut to Diazido Building Blocks for the Versatile Preparation of Photoaffinity Labeling Probes.
Authors: Yoshida Suguru , Misawa Yoshihiro , Hosoya Takamitsu 
Published: January 2015

AbstractBased on Ir‐catalyzed C—H borylation and subsequent Cu‐catalyzed azidation 3,5‐difunctionalized aryl azides (II) and (VI) are synthesized.
ChemInform Abstract: Concise Preparation of Optically Active Heteroaryl α‐(Hydroxyamino) Esters.
Authors: Murat‐Onana Marie Laure , Berini Christophe , Denis Jean‐Noel , Poisson Jean‐Francois , Minassian Frederic , Pelloux‐Leon Nadia 
Published: January 2015

AbstractThe highly diastereoselective addition of hetarenes to a chiral cyclic nitrone ((R)‐II) followed by methanolysis, oxidation with Pb(OAC)4 and reaction with hydroxylamine produces a range of α‐(hydroxylamino)esters in good yields and good enantioselectivities.
ChemInform Abstract: TMSCl‐Mediated Synthesis of α,β‐Unsaturated Amides via C—C Bond Cleavage and C—N Bond Formation of Propargyl Alcohols with Trimethylsilyl Azide.
Authors: Song Xian‐Rong , Song Bo , Qiu Yi‐Feng , Han Ya‐Ping , Qiu Zi‐Hang , Hao Xin‐Hua , Liu Xue‐Yuan , Liang Yong‐Min 
Published: January 2015

AbstractThe process involves the formation of allenyl azides and their subsequent Schmidt‐type rearrangement.
ChemInform Abstract: Application of TiO2 Nanoparticles for the Synthesis of N‐Arylureas in Water at Room Temperature.
Authors: Nasrollahzadeh Mahmoud 
Published: January 2015

AbstractTiO2 nanoparticles are an efficient, easily recoverable, and reusable heterogeneous catalyst for the synthesis of N‐arylureas (II) by hydration of cyanamides (I) using formic acid.
ChemInform Abstract: MIDA as a Simple and Highly Efficient Ligand for Palladium‐Catalyzed Hiyama Cross‐Coupling of Aryl Halides.
Authors: Guo Mengping , Qi Liang , Zhang Qiaochu , Zhu Zhiyong , Li Wei , Li Xiaogang 
Published: January 2015

AbstractA simple, easily obtained, air‐stable, and water‐soluble ligand for the palladium‐catalyzed cross‐coupling of aryl bromides with phenyl trimethoxysilane is described.
ChemInform Abstract: One‐Pot Regioselective Synthesis of meta‐Terphenyls via [3 + 3] Annulation of Nitroallylic Acetates with Alkylidenemalononitriles.
Authors: Gopi Elumalai , Namboothiri Irishi N. N. 
Published: January 2015

AbstractThe novel regioselective [3 + 3] annulation benefits from the 1,3‐bielectrophilic character of Morita—Baylis—Hillman (MBH) acetates and the 1,3‐binucleophilic character of alkylidenemalononitriles and is assumed to proceed in a cascade fashion comprising a SN2′ substitution, followed by intramolecular 6‐endo‐trig Michael addition and double elimination.
ChemInform Abstract: Copper‐ and Phosphine‐Free Sonogashira Coupling Reaction Catalyzed by Silica‐(acac)‐Supported Palladium Nanoparticles in Water.
Authors: Hajipour Abdol R. , Shirdashtzade Zohre , Azizi Ghobad 
Published: January 2015

AbstractCatalyst can be recycled and reused up to 5 times without appreciable loss in its activity.
ChemInform Abstract: Bmim(OH)/Chitosan/C2H5OH Synergy: Grinding Induced, a New Route for the Synthesis of Spiro‐Oxindole and Its Derivatives.
Authors: Srivastava Madhulika , Rai Pratibha , Singh Jaya , Singh Jagdamba 
Published: January 2015

AbstractA cost effective and powerful catalytic system is successfully applied to the title synthesis.
ChemInform Abstract: Combinatorial Synthesis of Nicotine Analogues Using an Ugi 4‐CR/Cyclization‐Reduction Strategy.
Authors: Polindara‐Garcia Luis A. , Vazquez Alfredo 
Published: January 2015

AbstractThe one‐pot synthesis of nicotine analogs from commercially available raw materials using Ugi four‐component reaction with subsequent reduction is presented.
ChemInform Abstract: [Silver(I)(Pyridine‐Containing Ligand)] Complexes as Unusual Catalysts for A3‐Coupling Reactions.
Authors: Trose Michael , Dell'Acqua Monica , Pedrazzini Tommaso , Pirovano Valentina , Gallo Emma , Rossi Elisabetta , Caselli Alessandro , Abbiati Giorgio 
Published: January 2015

AbstractThe reaction of aldehydes, alkynes, and amines is best catalyzed by the shown macrocyclic silver complex.
ChemInform Abstract: Taming Gold(I)‐Counterion Interplay in the De‐aromatization of Indoles with Allenamides.
Authors: Jia Minqiang , Cera Gianpiero , Perrotta Daniele , Monari Magda , Bandini Marco 
Published: January 2015

AbstractA systematic investigation of the gold‐catalyzed dearomatization of indoles with allenyl substituted tertiary amines is reported.
ChemInform Abstract: Enantioselective Fluorination of 2‐Oxindoles by Structure‐Micro‐Tuned N‐Fluorobenzenesulfonamides.
Authors: Wang Fajie , Li Juli , Hu Qingyang , Yang Xianjin , Wu Xin‐Yan , He Haoming 
Published: January 2015

AbstractA series of N‐fluorobenzenesulfonamides such as (I) is synthesized and screened in the enantioselective fluorination of oxindole (IIa).
ChemInform Abstract: Asymmetric Synthesis of Spiro‐epoxyoxindoles by the Catalytic Darzens Reaction of Isatins with Phenacyl Bromides.
Authors: Kuang Yulong , Lu Yan , Tang Yu , Liu Xiaohua , Lin Lili , Feng Xiaoming 
Published: January 2015

AbstractThe asymmetric Darzens reaction of phenacyl bromides and N‐protected isatins provides various spiro‐epoxyindoles.
ChemInform Abstract: Efficient Domino Synthesis of Pyrrole‐Fused Isocoumarins with Microwave Heating.
Authors: Sun Mu‐Yan , Meng Xiao‐Yan , Zhao Fu‐Jie , Dang Yi‐Jing , Jiang Fei , Liu Kai , Wang Cong‐Shuai , Jiang Bo , Tu Shu‐Jiang 
Published: January 2015

AbstractA novel microwave‐promoted three‐component domino reaction of the dihydroxydione (I) with primary amines (II) and acetylenedicarboxylates (III) proceeds through a ring‐opening and recyclization cascade to give isochromeno[4,3‐b]pyrroles in good yields.
ChemInform Abstract: Tandem Michael Addition/Imine Isomerization/Intramolecular [3 + 2] Cycloaddition for the Regiospecific Synthesis of Cyclohepta[b]pyrroles.
Authors: Zhang Yu , Pan Ling , Xu Xianxiu , Luo Hongmei , Liu Qun 
Published: January 2015

AbstractThe polarity reversible nature of azomethine imines as the crucial transformation enables the title reaction sequence to proceed under mild, transition‐metal‐free conditions.
ChemInform Abstract: Palladium‐Catalyzed Intramolecular Oxidative C—H Sulfuration of Aryl Thiocarbamates.
Authors: Zhao Yingwei , Xie Yinjun , Xia Chungu , Huang Hanmin 
Published: January 2015

AbstractA new synthesis from thiocarbamates to benzoxathiol‐2‐ones is developed.
ChemInform Abstract: Copper‐Catalyzed Direct Trifluoromethylation of Propiolates: Construction of Trifluoromethylated Coumarins.
Authors: Li Yuewen , Lu Yuan , Qiu Guanyinsheng , Ding Qiuping 
Published: January 2015

AbstractThis novel copper‐catalyzed radical addition of CF3 to activated alkynes followed by a sequential oxidation/cyclization provides direct access to trifluoromethylated coumarins.
ChemInform Abstract: Diastereoconvergent Synthesis of trans‐5‐Hydroxy‐6‐Substituted‐2‐piperidinones by Addition—Cyclization—Deprotection Process.
Authors: Si Chang‐Mei , Huang Wei , Du Zhen‐Ting , Wei Bang‐Guo , Lin Guo‐Qiang 
Published: January 2015

AbstractReaction of the α‐chiral aldimine derivative (I) with Grignard reagents proceeds through an addition/cyclization/deprotection reaction sequence to give 5,6‐disubstituted 2‐piperidinones in good diastereoselectivity.
ChemInform Abstract: Synthesis of Aza‐Fused Isoquinolines Through Domino Cross‐Aldol Condensation and Palladium‐Catalyzed Intramolecular Direct Arylation.
Authors: Dhiman Shiv , Pericherla Kasiviswanadharaju , Nandwana Nitesh K. , Kumar Dalip , Kumar Anil 
Published: January 2015

AbstractThe reaction fails using 2‐chlorobenzaldehyde instead of 2‐bromobenzaldehyde.
ChemInform Abstract: Organophosphorus‐Catalyzed Diaza‐Wittig Reaction: Application to the Synthesis of Pyridazines.
Authors: Bel Abed Hassen , Mammoliti Oscar , Bande Omprakash , Van Lommen Guy , Herdewijn Piet 
Published: January 2015

AbstractThe presented organophosphorus‐catalyzed diaza‐Wittig reaction affords substituted pyridazine derivatives bearing electron‐withdrawing groups with good to excellent yields.
ChemInform Abstract: Synthesis and Antiproliferative Evaluation of Novel Tetrahydrobenzo[4′,5′]thieno[3′,2′:5,6]pyrido[4,3‐d]pyrimidine Derivatives.
Authors: Tang Chu , Liang Yongju , Bai Shun , He Hongwu , Chen Yu , Yang Guangzhong , Fu Liwu 
Published: January 2015

AbstractIt is found that some Schiff base compounds (XII) show similar or even stronger antiproliferative activity than the positive control Fluorouracil against KB and CNE2 cell lines.
ChemInform Abstract: Dicopper Complexes Catalyzed Coupling/Cyclization of 2‐Bromobenzoic Acids with Amidines Leading to Quinazolinones.
Authors: Hung Ming‐Uei , Liao Bei‐Sih , Liu Yi‐Hong , Peng Shie‐Ming , Liu Shiuh‐Tzung 
Published: January 2015

AbstractPyrazole‐1‐carboxamidine and formamidinesulfinic acid do not react because of the decomposition of the substrates under this conditions.
ChemInform Abstract: Rhodium(III)‐Catalyzed Regioselective C—H Alkenylation of Phenylphosphine Sulfides.
Authors: Yokoyama Yuki , Unoh Yuto , Hirano Koji , Satoh Tetsuya , Miura Masahiro 
Published: January 2015

AbstractAn effective method for the Rh‐catalyzed ortho‐alkenylation of phenylphosphine sulfides is developed using a P=S group‐directed C‐H bond cleavage.
ChemInform Abstract: Bioinspired Total Synthesis of Sespenine.
Authors: Sun Yu , Chen Pengxi , Zhang Deliang , Baunach Martin , Hertweck Christian , Li Ang 
Published: January 2015

AbstractA bioinspired aza‐Prins/Friedel—Crafts/retro Friedel—Crafts cascade reaction is employed in the first total synthesis of the indole terpenoid sespenine.
ChemInform Abstract: Carpedilactones A—D, Four New Isomeric Sesquiterpene Lactone Dimers with Potent Cytotoxicity from Carpesium faberi.
Authors: Yang Yong‐Xun , Shan Lei , Liu Qing‐Xin , Shen Yun‐Heng , Zhang Jian‐Ping , Ye Ji , Xu Xi‐Ke , Li Hui‐Liang , Zhang Wei‐Dong 
Published: January 2015

AbstractFour new isomeric sesquiterpene lactone dimers, carpedilactones A (I), B (II), C (III), and D (IV) are isolated.
ChemInform Abstract: First Synthesis of Bacillus cereus Ch HF‐PS Cell Wall Trisaccharide Repeating Unit.
Authors: Podilapu Ananda Rao , Kulkarni Suvarn S. 
Published: January 2015

AbstractThe total synthesis of the title trisaccharide involves the transformation of D‐mannose into an orthogonally protected acetamido‐amino sugar building block, two stereoselective glycosylations, selective attachment of a glutaric acid linker, and an amide bond formation.
ChemInform Abstract: Novel Cytotoxic Nine‐Membered Macrocyclic Polysulfur Cembranoid Lactones from the Soft Coral Sinularia sp.
Authors: Zhang Cui‐Xian , et al. et al. 
Published: January 2015

AbstractThe cytotoxic activity of sinulariaoid A (+)‐(I), sinulariaoid B (+)‐(II), sinulariaoid C (+)‐(III), sinulariaoid D (+)‐(IV), capilloloid (V), dihydrosinularin (VI), sinularin (VII), and dihydrosinuflexolide (VIII) is evaluated with (+)‐(I) being the most potent compound in vitro.
ChemInform Abstract: Total Synthesis of Quebrachamine Through Macrolactamization.
Authors: Hsu Shih‐Wen , Cheng Hsiu‐Yi , Huang An‐Chi , Ho Tse‐Lok , Hou Duen‐Ren 
Published: January 2015

AbstractThe title compound quebrachamine (Ia) and kopsiyunnanine D (Ib) are synthesized from the same precursor.
ChemInform Abstract: Synthesis of Theaflavins with Camellia sinensis Cell Culture and Inhibition of Increase in Blood Sugar Values in High‐Fat Diet Mice Subjected to Sucrose or Glucose Loading.
Authors: Takemoto Masumi , Takemoto Hiroaki , Sakurada Asuka 
Published: January 2015

AbstractCamellia sinensis cell culture is employed as oxidizing enzyme to synthesize theaflavin (Ia) and its galloyl esters (Ib‐d).
ChemInform Abstract: Structural Features of Monomeric Octahedral D2 Rhenium(V) Oxo Complexes: The Structure of D2 Rhenium(V) Monooxo Compounds with Sulfur and Hydrogen Atoms trans to the O(oxo) Ligands
Authors: Sergienko V. S. 
Published: January 2015

AbstractReview: 13 refs.
Kombiniertes Katalysator‐ und Sauerstoffträgersystem zur Aufbereitung teerhaltiger Brenngase aus der Biomassevergasung via partieller Oxidation
Authors: Böhning Dorith , Beckmann Michael , Kriegel Ralf , Richter Jörg , Ma Mingshui , Müller Michael 
Published: January 2015

AbstractDie stoffliche und energetische Nutzung von Brenngasen aus der Vergasung von Biomasse steht seit vielen Jahren im Mittelpunkt umfangreicher Forschungen. Ein großes, bislang nicht vollständig gelöstes Problem ist dabei der hohe Anteil an höhersiedenden Kohlenwasserstoffen in den Brenngasen. Durch unvollständig ablaufende Vergasungsreaktionen und Nebenreaktionen werden diese Kohlenwasserstoffe, Phenole und Kohlenstoff gebildet, die für eine Weiternutzung des Gases gravierende Störkomponenten darstellen. Im Fokus dieses Beitrages steht die partielle Oxidation zur Teerreduzierung unter Einsatz von Katalysatoren. Im untersuchten Konzept wird die Bereitstellung des Sauerstoffs für die partielle Oxidation mit der katalytischen Wirkung in einem Festbett kombiniert.
ReadMax—a novel reading and scoring approach for EGFR gene copy number to predict therapeutic benefit of erlotinib treatment in EGFR wild‐type non‐small‐cell lung cancer
Authors: Moecks Joachim , Soulières Denis , Klughammer Barbara 
Published: January 2015

AbstractEGFR mutation testing is now well established as a means of selecting the optimal first‐line therapy for patients with advanced non‐small‐cell lung cancer (NSCLC). However, deciding on the correct treatment for EGFR wild‐type NSCLC remains a challenge. EGFR fluorescence in‐situ hybridization (FISH) testing of gene copy number has been a promising marker, but has provided mixed results despite attempts to standardize the reading and scoring process. The novel ReadMax reading and scoring system focuses on the most aberrant cells, to identify oncogene addiction, rather than taking a representative reading as in the Colorado method. The methodology was developed using historical samples from the TRUST and MERIT studies, followed by re‐reading of the samples from the SATURN trial. Analysis of samples using the ReadMax methodology revealed that progression‐free survival (PFS) and overall survival (OS) were improved in patients with ReadMax FISH‐positive (RM FISH+) tumours, compared with those whose tumours were not RM FISH+: PFS hazard ratios (HRs) were 0.52 for RM FISH+ versus 0.93 for not RM FISH+; OS HRs were 0.69 and 0.92, respectively. For PFS, HR for RM FISH+ versus not RM FISH+ in the SATURN erlotinib group was 0.53 (p = 0.003). The PFS and OS results were also similar in the EGFR wild‐type population (PFS HRs were 0.63 and 0.96; OS HRs were 0.61 and 0.84, respectively), although amplification of the EGFR gene in patients with EGFR wild‐type disease was not found to be predictive of treatment outcomes, which was unexpected but not unprecedented. KRAS status was not found to affect outcomes. Further experience is required to refine the ReadMax methodology and fully establish its validity and robustness. In conclusion, the ReadMax scoring system to identify patients with EGFR FISH‐positive NSCLC is a promising technique, which could improve treatment options and outcomes for patients with advanced NSCLC, in particular for EGFR wild‐type tumours.