bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions
Authors: Pabla Navjotsingh , Gibson Alice A. , Buege Mike , Ong Su Sien , Li Lie , Hu Shuiying , Du Guoqing , Sprowl Jason A. , Vasilyeva Aksana , Janke Laura J. , Schlatter Eberhard , Chen Taosheng , Ciarimboli Giuliano , Sparreboom Alex 
Published: April 2015

SignificanceAcute kidney injury (AKI) is a common clinical condition caused by loss of kidney function. Lack of therapeutic options has contributed to high mortality rates in AKI patients. Drug-induced AKI, as observed during cisplatin-based anticancer therapy, is responsible for about 20% of renal failure cases. The initial injury triggers a proliferative response in renal tubular cells, which in the presence of cellular damage can further accelerate renal injury. Our study provides evidence that the small-molecule cell-cycle inhibitors palbociclib and LEE011 can prevent cisplatin-induced AKI by inhibiting two relevant targets: renal cell-cycle progression and organic cation transporter 2, a renal uptake transporter of cisplatin. The future development of cyclin-dependent kinase 4/6 inhibitors as renal protective agents could have significant clinical benefits.
Environmental constraints drive the partitioning of the soundscape in fishes
Authors: Ruppé Laëtitia , Clément Gaël , Herrel Anthony , Ballesta Laurent , Décamps Thierry , Kéver Loïc , Parmentier Eric 
Published: April 2015

Significance
More and more studies stress the potential deleterious effect of anthropogenic sounds on fish acoustic communication. Paradoxically, how the communication between fishes in a community is organized remains extremely poorly known, as studies using passive acoustic recordings are typically restricted to one or two species. At a single site, we were able to follow 16 different vertebrate sounds for 15 days. We demonstrate that the fish population can be distributed into two groups: one diurnal and one nocturnal. Most interestingly, fish calling at night do not show overlap at the level of the main calling frequency, in contrast to fish calling during the day. This shows that at night, in the absence of visual cues, sound communication is more important.
Base-enhanced catalytic water oxidation by a carboxylate–bipyridine Ru(II) complex
Authors: Song Na , Concepcion Javier J. , Binstead Robert A. , Rudd Jennifer A. , Vannucci Aaron K. , Dares Christopher J. , Coggins Michael K. , Meyer Thomas J. 
Published: April 2015

SignificanceDevelopment of rapid, robust water oxidation catalysts remains an essential element in solar water splitting by artificial photosynthesis. We report here dramatic rate enhancements with added buffer bases for a robust Ru(II) polypyridyl catalyst with a calculated half-time for water oxidation of ∼7 μs in 1.0 M phosphate. The results of detailed kinetic studies provide insight into the water oxidation mechanism and an important role for added buffer bases in accelerating water oxidation by concerted atom–proton transfer.
Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective
Authors: Kaplan Anna , Gaschler Michael M. , Dunn Denise E. , Colligan Ryan , Brown Lewis M. , Palmer Arthur G. , Lo Donald C. , Stockwell Brent R. 
Published: April 2015

Significance
Protein disulfide isomerase (PDI) is a chaperone protein in the endoplasmic reticulum. It is up-regulated in mouse models of, and brains of patients with, neurological protein folding diseases. Irreversible inhibition of PDI activity by the small molecule 16F16 results in protection in cell and organotypic brain slice culture models of Huntington disease. Here, we identified lead optimized compound (LOC)14 as a nanomolar, reversible inhibitor of PDI that protects PC12 cells and medium spiny neurons from the toxic mutant huntingtin protein. LOC14 has improved potency compared with 16F16 and displays favorable pharmaceutical properties, making it a suitable compound to evaluate the therapeutic potential of inhibiting PDI in multiple disease models.
Mechanical cloak design by direct lattice transformation
Authors: Bückmann Tiemo , Kadic Muamer , Schittny Robert , Wegener Martin 
Published: April 2015

Significance
Calculating the behavior or function of a given material microstructure in detail can be difficult, but it is conceptually straightforward. The inverse problem is much harder. Herein, one searches for a microstructure that performs a specific targeted function. For example, one may want to guide a wave or a force field around some obstacle as though no obstacle were there. Such function can be represented by a coordinate transformation. Transformation optics maps arbitrary coordinate transformations onto concrete material-parameter distributions. Unfortunately, mapping this distribution onto a microstructure poses another inverse problem. Here, we suggest an alternative approach that directly maps a coordinate transformation onto a concrete one-component microstructure, and we apply the approach to the case of static elastic–solid mechanics.
Architecture of the cerebral cortical association connectome underlying cognition
Authors: Bota Mihail , Sporns Olaf , Swanson Larry W. 
Published: April 2015

Significance
Connections between cerebral cortex regions are known as association connections, and neural activity in the network formed by these connections is thought to generate cognition. Network analysis of microscopic association connection data produced over the last 40 years in a small, easily studied mammal suggests a new way to describe the organization of the cortical association network. Basically, it consists of four modules with an anatomical shell–core arrangement and asymmetric connections within and between modules, implying at least partly “hardwired,” genetically determined biases of information flow through the cortical association network. The results advance the goal of achieving a global nervous system wiring diagram of connections and provide another step toward understanding the cellular architecture and mechanisms underpinning cognition.
Acoustic separation of circulating tumor cells
Authors: Li Peng , Mao Zhangming , Peng Zhangli , Zhou Lanlan , Chen Yuchao , Huang Po-Hsun , Truica Cristina I. , Drabick Joseph J. , El-Deiry Wafik S. , Dao Ming , Suresh Subra , Huang Tony Jun 
Published: April 2015

Significance
The separation and analysis of circulating tumor cells (CTCs) provides physicians a minimally invasive way to monitor the response of cancer patients to various treatments. Among the existing cell-separation methods, acoustic-based approaches provide significant potential to preserve the phenotypic and genotypic characteristics of sorted cells, owing to their safe, label-free, and contactless nature. In this work, we report the development of an acoustic-based device that successfully demonstrates the isolation of rare CTCs from the clinical blood samples of cancer patients. Our work thus provides a unique means to obtain viable and undamaged CTCs, which can subsequently be cultured. The results presented here offer unique pathways for better cancer diagnosis, prognosis, therapy monitoring, and metastasis research.
Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade
Authors: Hathaway Catherine K. , Grant Ruriko , Hagaman John R. , Hiller Sylvia , Li Feng , Xu Longquan , Chang Albert S. , Madden Victoria J. , Bagnell C. Robert , Rojas Mauricio , Kim Hyung-Suk , Wu Bingruo , Zhou Bin , Smithies Oliver , Kakoki Masao 
Published: April 2015

SignificanceCongestive heart failure develops in human patients and experimental animals when the left ventricle becomes dilated. In the present study, mice were generated having graded genetic levels of endothelin-1 from 20% normal to 350% normal by modifying the 3′ untranslated region of the endothelin-1 gene. The 20% and 65% hypomorphs develop dilated cardiomyopathy, whereas the 350% hypermorph has a hypertrophic heart. Increases in superoxide levels and overexpression of matrix metalloproteinase 9 (MMP9) are involved in the development of the dilated cardiomyopathy in the 20% hypomorph. Our results show that endothelin-1 is critical for maintaining normal cardiac contractile function, for controlling superoxide and Mmp9 levels, and for ensuring that the myocardium has sufficient collagen to prevent overstretching.
Mimicking the magnetic properties of rare earth elements using superatoms
Authors: Cheng Shi-Bo , Berkdemir Cuneyt , Castleman A. W. 
Published: April 2015

Significance
Superatom concept has been found to be promising in designing atomic clusters to mimic the chemistry of scarce or expensive elements. Also, longstanding interest and challenge exist in searching for suitable candidates to mimic the valuable properties of rare earth elements owing to their highly important application in modern technologies and extremely low yield. Herein, by using photoelectron imaging spectroscopy, we provide direct experimental evidence that well-designed boron-doped clusters, namely LaB and NdB, could be promising candidates to mimic the magnetic properties of corresponding rare earth atoms Nd and Eu, respectively, because the same numbers of valence electrons, unpaired electrons, and magnetic moments are found in both of the counterparts. This finding opens up an exciting possibility for rare earth mimicry using the superatom concept.
Alternative approach to protein structure prediction based on sequential similarity of physical properties
Authors: He Yi , Rackovsky S. , Yin Yanping , Scheraga Harold A. 
Published: April 2015

Significance
The traditional approaches to alignment, in general, are based on evolutionary preconceptions. As a result, prebiasing encoded in these methodologies produces results that tend to be in accordance with initial expectation. A method of sequence alignment in which residue equivalence is based entirely on the physical properties of amino acids is introduced here. This approach has no bias in favor of any sequence dataset, eliminates much of the computational complexity inherent in traditional approaches, and gives good results for structures that were poorly predicted in the two most recent CASP exercises.
Estrogen receptor β exon 3-deleted mouse: The importance of non-ERE pathways in ERβ signaling
Authors: Maneix Laure , Antonson Per , Humire Patricia , Rochel-Maia Sabrina , Castañeda Jessica , Omoto Yoko , Kim Hyun-Jin , Warner Margaret , Gustafsson Jan-Åke 
Published: April 2015

Significance
Estrogen receptor β (ERβ) is thought to be the predominant nuclear receptor that regulates estrogen signaling in a wide variety of tissues. In several circumstances, it can oppose the effects of ERα. Here, we generated a novel ERβ exon 3-deleted mouse model (ERβ-Δex3) in which the first zinc finger of the DNA binding domain is missing but the remaining C-terminus part of the receptor is present. We observed that mutant male mice were normal but females were anovulatory. Thus, this work demonstrates that most of the physiological functions of ERβ do not involve estrogen response element binding.
Extraction of crude polysaccharides from Duchesnea indica (Andrews) Focke: optimization by response surface methodology
Authors: Chen Jing , Sun Chao , Han Liang , Lin Xi , Wang Li , Shen Minna , Yu Fei , Chen Jianhua 
Published: April 2015

Abstract
A full set of optimization procedure was applied to the extraction of anti-viral polysaccharides from Duchesnea indica (Andrews) Focke. By Plackett–Burman factorial design, three parameters (extraction time, extraction temperature, and ratio of water to raw material) were identified as significant to the extraction yield. However, no significant parameters had been identified for antiviral activity. A three-level-three-factor Box–Behnken factorial design was then employed to further optimize the extraction condition. The experimental data were fitted to a second-order polynomial equation using multiple regression analysis and also examined using appropriate statistical methods. This led to the construction of a response surface indicating the optimal values for each parameter and response studied. Concerning the extraction yield, an extraction at 98.51 ºC for 6.16 h with a ratio of water to raw material of 30.94 mL/g was found to be optimal. Under the optimized conditions, the experimental yield was 6.430 ± 0.078%, which was well matched with the predicted yield of 6.509%.
SMY2 and SYH1 suppress defects in ribosome biogenesis caused by ebp2 mutations
Authors: Okano Akira , Wan Kun , Kanda Kazuhiro , Yabuki Yukari , Funato Kouichi , Mizuta Keiko 
Published: April 2015

Abstract
Ebp2 is an assembly factor of the 60S ribosomal subunit in yeast. We demonstrate that overexpression of SMY2 or SYH1 partially suppresses defects in growth and ribosome biogenesis of ebp2 mutants, and that smy2Δ and syh1Δ exhibit synthetic growth defects with the ebp2 allele. These results suggest that Smy2 and Syh1 may be involved in ribosome biogenesis in relation to Ebp2.
Localization and functional characterization of the extrinsic subunits of photosystem II: an update
Authors: Ifuku Kentaro 
Published: April 2015

Abstract
Photosystem II (PSII), which catalyzes photosynthetic water oxidation, is composed of more than 20 subunits, including membrane-intrinsic and -extrinsic proteins. The extrinsic proteins of PSII shield the catalytic Mn4CaO5 cluster from exogenous reductants and serve to optimize oxygen evolution at physiological ionic conditions. These proteins include PsbO, found in all oxygenic organisms, PsbP and PsbQ, specific to higher plants and green algae, and PsbU, PsbV, CyanoQ, and CyanoP in cyanobacteria. Furthermore, red algal PSII has PsbQ′ in addition to PsbO, PsbV, and PsbU, and diatoms have Psb31 in supplement to red algal-type extrinsic proteins, exemplifying the functional divergence of these proteins during evolution. This review provides an updated summary of recent findings on PSII extrinsic proteins and discusses their binding, function, and evolution within various photosynthetic organisms.
American Women's History: A Very Short Introduction
Authors: Ware Susan 
Published: April 2015

Abstract
What does U.S. history look like with women at the center of the story? From Pocahantas to military women serving in the Iraq war, American Women's History: A Very Short Introduction chronicles the contributions, recognized and unrecognized, that women have made to the American experience. It recognizes the diversity of American women's experiences defined by race, ethnicity, and class, but also geography, sexual orientation, age, and religion. At the core of the narrative is the recognition that gender—the changing historical and cultural constructions of roles assigned to the biological differences of the sexes—is central to understanding the history of American women's lives, and the history of the United States.
MetaMapR: pathway independent metabolomic network analysis incorporating unknowns
Authors: Grapov Dmitry , Wanichthanarak Kwanjeera , Fiehn Oliver 
Published: April 2015

Abstract
Summary: Metabolic network mapping is a widely used approach for integration of metabolomic experimental results with biological domain knowledge. However, current approaches can be limited by biochemical domain or pathway knowledge which results in sparse disconnected graphs for real world metabolomic experiments. MetaMapR integrates enzymatic transformations with metabolite structural similarity, mass spectral similarity and empirical associations to generate richly connected metabolic networks. This open source, web-based or desktop software, written in the R programming language, leverages KEGG and PubChem databases to derive associations between metabolites even in cases where biochemical domain or molecular annotations are unknown. Network calculation is enhanced through an interface to the Chemical Translation System, which allows metabolite identifier translation between &gt;200 common biochemical databases. Analysis results are presented as interactive visualizations or can be exported as high-quality graphics and numerical tables which can be imported into common network analysis and visualization tools.
Availability and Implementation: Freely available at http://dgrapov.github.io/MetaMapR/. Requires R and a modern web browser. Installation instructions, tutorials and application examples are available at http://dgrapov.github.io/MetaMapR/.
Contact: ofiehn@ucdavis.edu
How Do You Make the Diagnosis?
Authors: Brody David L 
Published: April 2015

To make a diagnosis of concussion, you need a reliable history of two things: (1) an acute external physical force applied to the brain and (2) an impairment in the function of the brain directly caused by the external physical force. One or the other is not enough. You need both. You do not need a scan to make the diagnosis. No scan can “rule in” or “rule out” concussion. You do not need to perform a detailed neurological exam to make the diagnosis. The neurological exam is usually unremarkable except for immediately after the concussion. no exam findings “rule in” or “rule out” concussion. A collateral source is key to obtaining a reliable history. The impairment in brain function occurs immediately after the event. The impairment is worst immediately after the event, then gradually improves. There is no other obvious explanation for the impairment.
Which Problems Do You Address First?
Authors: Brody David L 
Published: April 2015

Concussion patients often have a lot of things going on at the same time. Consider these three principles: (1) Ask the patient what’s bothering him the most. Often it is pain. Migraine headaches, for example, can be terrible. Try to deeply understand the patient’s life to figure out what matters most. (2) Ask the collateral source what is causing the most problems in the patient’s life. Often it is mood instability. “He’s not the same person” is a common complaint. Sometimes, the most important problems following concussion are not immediately apparent to the patient. (3) Look for the “top of the cascade”—one single problem that is the root cause of one or more additional problems. For example, sleep disruption can in turn worsen memory, attention, pain, mood disorders and many other symptoms. Major depression can impair virtually every aspect of life including energy, sleep, pain, attention, and memory.
General Treatment Strategies
Authors: Brody David L 
Published: April 2015

This chapter discusses the top 10 general priorities in treating concussion: (1) Do one thing at a time. (2) Stop or taper impairing medications before adding new ones. (3) Minimize side effects of medications. (4) Offer rehabilitative therapy and lifestyle modification interventions as well as medications. (5) Educate and comfort. (6) Give an honest prognosis with a positive spin. (7) Use a healthy dose of “Vitamin P” (“placebo”) in an appropriate way. (8) Under the right circumstances, it’s ok to use a big dose of “Vitamin S” (the “therapeutic scare”) also. (9) Offer follow-up and appropriate referrals. (10) Support the family.
Headaches
Authors: Brody David L 
Published: April 2015

This chapter presents four rules for treating concussion headache: (1) Triage is more important than diagnosis. Take a careful history by asking specific hypothesis testing questions. Examine the patient. This is important. You can’t do it over the phone. (2) Migraines are really common after concussion; an atypical presentation of migraine is still more likely than most other types of headaches. Consider nonpharmacological measures, triptans, over the counter analgesics, and good prophylaxis as for regular migraine. (3) Patients can have more than one type of headache at the same time. (4) Patients with medication overuse headache aren’t going to get better from anything you do until the medication overuse is addressed. Consider admitting patients with medication overuse headaches to the hospital.
Attention Deficit
Authors: Brody David L 
Published: April 2015

Many concussion patients who complain about problems with memory actually have an attention deficit. General measures: treat insomnia, stop alcohol, prescribe moderate cardiovascular exercise, and refer for cognitive rehabilitation (occupational and speech therapy). Consider treatment with a stimulant such as methylphenidate (Ritalin), amphetamine mixed salts (Adderall), and atomoxetine (Strattera), if appropriate, with careful monitoring for side effects. Contraindications include uncontrolled seizures, dangerous anxiety, active cardiovascular or cerebrovascular disease, active psychosis, drug abuse, irresponsible criminal behavior, dangerously underweight, and uncontrolled headaches. Recommend use is 6 days per week 51 weeks per year to reduce tolerance. Some patients find additional benefit from donepezil, rivastigmine, and regulated caffeine use. Approach options: “aggressive,” involving treatment with stimulants primarily based on history; “moderate,” involving treatment with stimulants only in patients with attention performance impairments documented with neuropsychological evaluation; and “conservative,” not including stimulants unless there is a well-documented history of preinjury attention deficit disorder.
Excessive Sleepiness
Authors: Brody David L 
Published: April 2015

The definition of clinically important hypersomnia is excessive sleep that interferes with other aspects of life. Take a careful history including from the collateral source. Administer the Epworth sleepiness scale to assess severity. Restrict driving if necessary: A severely hypersomnolent patient can be just as dangerous as an epileptic patient. Refer for an overnight polysomnogram (“sleep study”) at a licensed sleep lab, then treat any underlying disorders causing poor quality sleep. Assess for depression and, if appropriate, treat with an activating antidepressant. Take a careful medication history for substances that can cause hypersomnia and stop them if possible. Rule out a systemic cause. If these are not present or hypersomnia is still impairing after treatment, consider prescribing a very gradually progressive exercise program, a trial of caffeine, modafinil, or a direct stimulant in the most refractory cases.
Psychosis
Authors: Brody David L 
Published: April 2015

New onset hallucinations and delusions are rare after isolated concussion and should trigger a search for other causes: Schizophrenia (relatively common in young adults), drug abuse, alcohol or drug withdrawal, and delirium due to infection or sleep deprivation should be considered. Importantly, if the psychosis is dangerous or potentially dangerous, think about safety first. This may require inpatient admission to a psychiatric service. If outpatient treatment is required, atypical antipsychotics should be used in as low a dose as possible to minimize cognitive side effects. Aripiprazole (Abilify) is associated with less weight gain than others. Risperidone (Risperdal) is the least expensive. Quetiapine (Seroquel) or, rarely, clozaril are the best choices when parkinsonism is a comorbidity.
Staffing
Authors: Brody David L 
Published: April 2015

Pick the right people: a concussion clinic requires greater than average interpersonal skills to handle patients with mood instability and cognitive impairment. The clinic administrator needs to have good judgment. The administrator needs to be able to determine whether to contact the provider right away for an urgent issue, whether to recommend that the patient go straight to an emergency department, or whether a patient would be more appropriate for another clinic. Options: Physical therapist in clinic to perform balance testing and exertional testing and psychometrician in clinic to perform brief cognitive testing,