Hepatitis C Virus Reinfection Among People Who Inject Drugs
Authors: Litwin Alain H. , Tsui Judith I. , Heo Moonseong , Mehta Shruti H. , Taylor Lynn E. , Lum Paula J. , Feinberg Judith , Kim Arthur Y. , Norton Brianna L. , Pericot-Valverde Irene , Arnsten Julia , Meissner Paul , Karasz Alison , McKee M. Diane , Ward John W. , Johnson Nirah , Agyemang Linda , Stein Ellen S. , Thomas Aurielle , Borsuk Courtney , Blalock Kendra L. , Wilkinson Samuel , Wagner Katherine , Carty Jillian , Murray-Krezan Cristina , Anderson Jessica , Jacobsohn Vanessa , Luetkemeyer Anne F. , Falade-Nwulia Oluwaseun , Groome Megan , Davies Suzanne , Costello Kevin , Page Kimberly ,   HERO Study Group, James Jocelyn R , Kim Nina , Peavy Michelle , Ramchandani Meena S , King Ashley , Dickerson Brian , Fingerhood Michael , Haselhuhn Taryn , Mason Angela , Moon Juhi , Olsen Yngvild , Walters Vickie , Schmitt William , Lijewski Virginia , Pitts Anita , Raji Syeda , Silva Taniya , Evans Fiona , Koene Hope , Brown Joelle , Aneja Jasneet , Lora Kiara , Hidalgo Jennifer , Soloway Irene , Jefferson Karen , Wong Joyce , Kermack Andrea , Stein Melissa , Joseph Giliane , London Karyn , Allen Lincoln , Marte Venecia , Vera Tatiana , Alvarez Romy , Cullen Caycee , Gill Gurjot , Tierney Hannah , Shapiro Scott , Azari Soraya , Eveland Joanna , Berrner Daniel , Grey Pauli , Akerley Jordan , Davis Herbert , Tashima Karen , Sprecht-Walsh Sophie , Hordes Melissa , McGregor Danielle , Duryea Patrick , Weenig Kathryn , Grekin Paul , Ninburg Michael , Kelley Lacey , Calkins Andrea , Henry Gabrielle , Thomas Danielle , Ashler Alice , Teshale Eyasu , Seiguer Sebastian , Rios Katrina , Brown Lauren , Spellman James , Raymond Daniel , Beane Susan , Kapoor Hema 
Published: August 2024

IMPORTANCEHepatitis C virus (HCV) reinfection after curative treatment remains a concern for people who inject drugs.OBJECTIVETo assess the incidence of HCV reinfection and associated risk factors.DESIGN, SETTING, AND PARTICIPANTSThis cohort study is a secondary analysis of a randomized clinical trial that was conducted across opioid treatment programs and community health centers in the US between September 2016 and August 2018. The current analyses were performed in March 2022. People who inject drugs who achieved sustained virologic response (SVR) were followed for up to 42 months.ExposurePatients were randomly assigned to receive modified directly observed therapy or patient navigation.MAIN OUTCOMES AND MEASURESThe primary outcome was rate of HCV reinfection. Change in reinfection rates over time was assessed using a Poisson regression model.RESULTSA total of 415 participants (mean [SD] age, 44.7 [11.5] years; 302 male [72.8%]) achieved a SVR and had 1 or more post-SVR assessments for HCV RNA. Overall, 302 (72.8%) reported recent injection drug use, 192 (46.3%) were living in unstable housing, and 313 (75.4%) had received recent methadone or buprenorphine for opioid use disorder. The overall reinfection rate was 11.4 per 100 person-years at risk (95% CI, 8.7-14.7 per 100 person-years at risk) over 518 person-years of follow-up. Reinfection rates varied significantly across sites, ranging from 2.9 per 100 person-years at risk (95% CI, 0.1-16.3 per 100 person-years) to 25.2 per 100 person-years at risk (95% CI, 15.6-38.5 per 100 person-years at risk) (P = .006). There was a significant decrease in incident reinfection with increasing post-SVR follow-up (weeks 0-24, 15.5 per 100 person-years; 95% CI, 10.3-22.3 per 100 person-years; weeks 73-144, 4.3 per 100 person-years; 95% CI, 0.9-12.5 per 100 person-years;P = .008). Reinfection rates were lower for participants aged 40 years or older than for younger participants (adjusted incidence rate ratio, 0.32; 95% CI, 0.18-0.57) and for participants for whom methamphetamine was not detected in urinary drug screening compared with participants for whom methamphetamine was detected (adjusted incidence rate ratio, 0.41; 95% CI, 0.21-0.82). Participants who reported injection drug use within the preceding 3 months had higher risk of reinfection than those who did not have recent injection drug use (adjusted incidence rate ratio, 3.33; 95% CI, 1.86-5.97).CONCLUSIONS AND RELEVANCEIn this cohort study of people who injected drugs and were treated for HCV infection in community settings, reinfection was high in the period immediately after SVR but decreased significantly over time. These findings highlight the importance of early intervention to prevent reinfection.Trial RegistrationClinicalTrials.gov Identifier:NCT02824640