bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of prostate‐specific antigen testing as a disease surveillance tool following radical prostatectomy
Authors: Trantham Laurel Clayton , Nielsen Matthew E. , Mobley Lee R. , Wheeler Stephanie B. , Carpenter William R. , Biddle Andrea K. 
Published: July 2013

BACKGROUNDProstate‐specific antigen (PSA) testing is recommended every 6 to 12 months for the first 5 years following radical prostatectomy as a means to detect potential disease recurrence. Despite substantial research on factors affecting treatment decisions, recurrence, and mortality, little is known about whether men receive guideline‐concordant surveillance testing or whether receipt varies by year of diagnosis, time since treatment, or other individual characteristics.METHODSSurveillance testing following radical prostatectomy among elderly men was examined using Surveillance, Epidemiology, and End Results cancer registry data linked to Medicare claims. Multivariate logistic regression was used to examine the effect of demographic, tumor, and county‐level characteristics on the odds of receiving surveillance testing within a given 1‐year period following treatment.RESULTSOverall, receipt of surveillance testing was high, with 96% of men receiving at least one test the first year after treatment and approximately 80% receiving at least one test in the fifth year after treatment. Odds of not receiving a test declined with time since treatment. Nonmarried men, men with less‐advanced disease, and non‐Hispanic blacks and Hispanics had higher odds of not receiving a surveillance test. Year of diagnosis did not affect the receipt of surveillance tests.CONCLUSIONSMost men receive guideline‐concordant surveillance PSA testing after prostatectomy, although evidence of a racial disparity between non‐Hispanic whites and some minority groups exists. The decline in surveillance over time suggests the need for well‐designed long‐term surveillance plans following radical prostatectomy. Cancer 2013;119:3523–3530.. © 2013 American Cancer Society.
“Colloid‐Rich” follicular neoplasm/suspicious for follicular neoplasm thyroid fine‐needle aspiration specimens: Cytologic, histologic, and molecular basis for considering an alternate view
Authors: Ohori N. Paul , Wolfe Jenna , Hodak Steven P. , LeBeau Shane O. , Yip Linwah , Carty Sally E. , Duvvuri Umamaheswar , Schoedel Karen E. , Nikiforova Marina N. , Nikiforov Yuri E. 
Published: July 2013

BACKGROUNDTypically, thyroid follicular neoplasm/suspicious for follicular neoplasm (FN/SFN) cases show moderate to marked cellularity and scant or absent colloid. Recently, cases have been noted with microfollicular cellularity in the background of moderate to abundant amount of colloid. The purpose of this study was to compare these “colloid‐rich” FN/SFN cases to the typical FN/SFN cases.METHODSThyroid cytology specimens with the features of FN/SFN were searched in cytopathology files from September 2008 to June 2012. Cases with absent or minimal colloid were designated “typical colloid‐poor” FN/SFN and cases with moderate to abundant colloid were designated “colloid‐rich” FN/SFN. From these cases, those with surgical pathology resection follow‐up were identified. Cytologic, surgical pathology resection, and molecular features (BRAF, RAS, RET/PTC, and PAX8‐PPARγ) were investigated for the typical colloid‐poor FN/SFN cases and were compared with those of the colloid‐rich FN/SFN cases.RESULTSOf 431 FN/SFN cases with surgical pathology resection follow‐up, 360 (83.5%) cases showed features of typical colloid‐poor FN/SFN and 71 (16.5%) cases showed features of colloid‐rich FN/SFN. Papillary carcinoma was the most common malignant outcome for the 2 groups. Although the proportion of malignant outcome was similar for the 2 groups, the “colloid‐rich” FN/SFN cases showed a greater proportion of nodular hyperplasia among the cases with benign outcome. In addition, the “colloid‐rich” FN/SFN cases demonstrated a greater proportion of cases with a mutation.CONCLUSIONSApproximately one‐sixth of cases of FN/SFN show “colloid‐rich” features. Comparison to the typical colloid‐poor FN/SFN demonstrated similar risk for malignancy but contrasting resection outcome and molecular characteristics. Cancer (Cancer Cytopathol) 2013;121:718–728. © 2013 American Cancer Society.
Grading epithelial atypia in endoscopic ultrasound‐guided fine‐needle aspiration of intraductal papillary mucinous neoplasms: An international interobserver concordance study
Authors: Pitman Martha B. , Centeno Barbara A. , Genevay Muriel , Fonseca Ricardo , Mino‐Kenudson Mari 
Published: July 2013

BACKGROUNDPreoperative cytological analysis of cyst fluid from intraductal papillary mucinous neoplasms (IPMN) contributes to risk stratification for malignancy. To the authors' knowledge, agreement among pathologists in grading epithelial atypia in IPMN cyst fluids has not been studied to date.METHODSBlinded to the histological grade, 4 observers independently graded 60 cell groups from endoscopic ultrasound‐guided fine‐needle aspiration samples of 24 IPMNs of various grades as either 0 (nonlesional), 1 (low‐grade dysplasia), 2 (intermediate‐grade dysplasia [IGD]), 3 (high‐grade dysplasia), or 4 (invasive adenocarcinoma). The percentage of agreement and the kappa (k) coefficient were calculated for these 5 tiers and a reduced 2‐tier grouping (low‐grade [LG] [0‐1 and 0‐2] vs high‐grade [HG] [2‐4 and 3‐4]). Agreement between the 2 most experienced reviewers established a consensus diagnosis that was compared with the histological grade.RESULTSAmong the 4 reviewers there was poor agreement using a 5‐tiered system and fair agreement with the 2‐tiered system. LG and HG grouping of IGD did not appear to greatly affect agreement, with 54% agreement for grouping 0 to 2 and 3 to 4 (k = 0.45) and 52% agreement for grouping 0 to 1 and 2 to 4 (k = 0.44). The 2 most experienced reviewers had 87% agreement for the 0 to 2 and 3 to 4 grouping (k = 0.74) and 88% for the 0 to 1 and 2 to 4 grouping (k = 0.71). HG atypia on cytology with IGD grouped as LG yielded a sensitivity of 82%, with a specificity of 70% for detecting a cyst with HG morphology.CONCLUSIONSGrading cellular atypia in cyst fluids requires experience, which results in very good interobserver agreement and good correlation with histology using a 2‐tiered LG and HG grading system and IGD classified as LG. Cancer (Cancer Cytopathol) 2013;121:729–736. © 2013 American Cancer Society.
Alzheimer's disease pathology in the neocortex and hippocampus of the western lowland gorilla (Gorilla gorilla gorilla)
Authors: Perez Sylvia E. , Raghanti Mary Ann , Hof Patrick R. , Kramer Lynn , Ikonomovic Milos D. , Lacor Pascale N. , Erwin Joseph M. , Sherwood Chet C. , Mufson Elliott J. 
Published: July 2013

ABSTRACTThe two major histopathologic hallmarks of Alzheimer's disease (AD) are amyloid beta protein (Aβ) plaques and neurofibrillary tangles (NFT). Aβ pathology is a common feature in the aged nonhuman primate brain, whereas NFT are found almost exclusively in humans. Few studies have examined AD‐related pathology in great apes, which are the closest phylogenetic relatives of humans. In the present study, we examined Aβ and tau‐like lesions in the neocortex and hippocampus of aged male and female western lowland gorillas using immunohistochemistry and histochemistry. Analysis revealed an age‐related increase in Aβ‐immunoreactive plaques and vasculature in the gorilla brain. Aβ plaques were more abundant in the neocortex and hippocampus of females, whereas Aβ‐positive blood vessels were more widespread in male gorillas. Plaques were also Aβ40‐, Aβ42‐, and Aβ oligomer‐immunoreactive, but only weakly thioflavine S‐ or 6‐CN‐PiB‐positive in both sexes, indicative of the less fibrillar (diffuse) nature of Aβ plaques in gorillas. Although phosphorylated neurofilament immunostaining revealed a few dystrophic neurites and neurons, choline acetyltransferase‐immunoreactive fibers were not dystrophic. Neurons stained for the tau marker Alz50 were found in the neocortex and hippocampus of gorillas at all ages. Occasional Alz50‐, MC1‐, and AT8‐immunoreactive astrocyte and oligodendrocyte coiled bodies and neuritic clusters were seen in the neocortex and hippocampus of the oldest gorillas. This study demonstrates the spontaneous presence of both Aβ plaques and tau‐like lesions in the neocortex and hippocampus in old male and female western lowland gorillas, placing this species at relevance in the context of AD research. J. Comp. Neurol. 521:4318–4338, 2013. © 2013 Wiley Periodicals, Inc.
Comparative neuroanatomical parcellation of the human and nonhuman primate temporal pole
Authors: Insausti Ricardo 
Published: July 2013

ABSTRACTThe temporal pole is unique to nonhuman and human primates, although other species also present temporal cortex. A clear distinction is made between the gross anatomical, macroscopic temporal pole, located at the tip of the temporal lobe, and the temporal polar cortex, which is a general term that encompasses all reported divisions and can be applied to both nonhuman and human primates. In the 19th century early neuroanatomists identified the temporal polar cortex as a different entity, independent from the remainder of the temporal lobe. More recently, the temporal polar cortex has been subdivided into different fields. The analysis of the different portions that make up the temporal polar cortex was first described in the nonhuman primate, and later on in humans. In this review we examine the historical course of the concepts about the extension, structure, and main cytoarchitectonic areas. The different descriptions are presented in chronological order and their relevance is discussed. In general, some common features arise in nonhuman and human primates temporopolar cortex, namely, an increased thickness of this cortical area, a predominant dysgranular type of cortex, and a more restricted extension in humans relative to earlier accounts. A common pattern of cytoarchitectonic areas results from the criteria of previous authors, although the sulcal anatomy of the human temporal pole has great variability. The understanding of the extension, composition, and limits of the temporal polar cortex is crucial for identification of separate regions in neuroimaging studies. J. Comp. Neurol. 521:4163–4176, 2013. © 2013 Wiley Periodicals, Inc.
Medial temporal cortices in ex vivo magnetic resonance imaging
Authors: Augustinack Jean C. , van der Kouwe André J.W. , Fischl Bruce 
Published: July 2013

ABSTRACTThis review focuses on the ex vivo magnetic resonance imaging (MRI) modeling of medial temporal cortices and associated structures, the entorhinal verrucae and the perforant pathway. Typical in vivo MRI has limited resolution due to constraints on scan times and does not show laminae in the medial temporal lobe. Recent studies using ex vivo MRI have demonstrated lamina in the entorhinal, perirhinal, and hippocampal cortices. These studies have enabled probabilistic brain mapping that is based on the ex vivo MRI contrast, validated to histology, and subsequently mapped onto an in vivo spherically warped surface model. Probabilistic maps are applicable to other in vivo studies. J. Comp. Neurol. 521:4177–4188, 2013. © 2013 Wiley Periodicals, Inc.
Learning in Alzheimer's disease is facilitated by social interaction
Authors: Duff Melissa C. , Gallegos Diana R. , Cohen Neal J. , Tranel Daniel 
Published: July 2013

ABSTRACTSeminal work in Gary Van Hoesen's laboratory at Iowa in the early 1980s established that the hallmark neuropathology of Alzheimer's disease (AD; neurofibrillary tangles) had its first foothold in specific parts of the hippocampal formation and entorhinal cortex, effectively isolating the hippocampus from much of its input and output and causing the distinctive impairment of new learning that is the leading early characteristic of the disease (Hyman et al., 1984). The boundaries and conditions of the anterograde memory defect in patients with AD have been a topic of intense research interest ever since (e.g., Graham and Hodges, 1977; Nestor et al., 2006). For example, it has been shown that patients with AD may acquire some new semantic information through methods such as errorless learning, but learning under these conditions is typically slow and inefficient. Drawing on a learning paradigm (a collaborative referencing task) that was previously shown to induce robust and enduring learning in patients with hippocampal amnesia, we investigated whether this task would be effective in promoting new learning in patients with AD. We studied five women with early‐stage AD and 10 demographically matched healthy comparison participants, each interacting with a familiar communication partner. AD pairs displayed significant and enduring learning across trials, with increased accuracy and decreased time to complete trials, in a manner indistinguishable from healthy comparison pairs, resulting in efficient and economical communication. The observed learning here most likely draws on neural resources outside the medial temporal lobes. These interactive communication sessions provide a potent learning environment with significant implications for memory intervention. J. Comp. Neurol. 521:4356–4369, 2013. © 2013 Wiley Periodicals, Inc.
Development of reconfigurable distributed embedded systems with a model‐driven approach
Authors: Krichen Fatma , Hamid Brahim , Zalila Bechir , Jmaiel Mohamed , Coulette Bernard 
Published: July 2013

SummaryIn this paper, we propose a model‐driven approach allowing to build reconfigurable distributed real‐time embedded (DRE) systems. The constant growth of the complexity and the required autonomy of embedded software systems management give the dynamic reconfiguration a big importance. New challenges to apply the dynamic reconfiguration at model level as well as runtime support level are required. In this direction, the development of reconfigurable DRE systems according to traditional processes is not applicable. New methods are required to build and to supply reconfigurable embedded software architectures. In this context, we propose an model‐driven engineering based approach that enables to design reconfigurable DRE systems with execution framework support. This approach leads the designer to specify step by step his/her system from a model to another one more refined until the targeted model is reached. This targeted model is related to a specific platform leading to the generation of the most part of the system implementation. We also develop a new middleware that supports reconfigurable DRE systems. Copyright © 2013 John Wiley & Sons, Ltd.
Tailoring the network to the problem: topology configuration in hybrid electronic packet switched/optical circuit switched interconnects
Authors: Christodoulopoulos Kostas , Katrinis Kostas , Ruffini Marco , O'Mahony Donal 
Published: July 2013

SUMMARYWe consider a hybrid electronic packet switched and optical circuit switched interconnection network for future high performance computing and datacenter systems. Given the logical task‐to‐task communication graph of an application, our objective is to cluster the logical parallel tasks to compute resources and configure the (reconfigurable) optical part of the hybrid interconnect to efficiently serve application communication requirements. We formulate the clustering and topology configuration problem in such a network, prove that it is NP‐complete, and provide an optimal algorithm to solve it based on an integer linear programming formulation. The integer linear programming algorithm is used to optimally solve small‐scale instances of the problem for the purpose of obtaining performance bounds. Aiming at large‐scale, we also present a heuristic based on simulated annealing that trades‐off performance for responsiveness. We measure the performance of a hybrid interconnect employing the proposed algorithm using real workloads, as well as extrapolated traffic, and compare it against application mapping on conventional fixed, electronic‐only interconnects based on toroidal topologies. Copyright © 2013 John Wiley & Sons, Ltd.
Superhydrophobic Conducting Polymers Based on Hydrocarbon Poly(3,4‐Ethylenedioxyselenophene)
Authors: Dunand Oceane , Darmanin Thierry , Guittard Frederic 
Published: July 2013

AbstractWe report the first studied example of wettability of conducting polymers based on poly(3,4‐ethylenedioxyselenophene). Hydrocarbon 3,4‐ethylenedioxyselenophene (C2H5 to C12H25) derivatives are synthesized and electropolymerized in propylene carbonate using lithium tetrafluoroborate (LiBF4) and lithium bistrifluoromethanesulfonimidate (LiTf2N) as electrolyte. Highly structured films are obtained from a C8H17 chain independent of the electrolyte used. Superhydrophobic properties with high adhesion are specifically reached if using a C12H25 chain and LiBF4. The surface morphology is porous and highly structured as the films consist of assemblies of nanofibrils.
Imidazolium‐Based Poly(ionic liquid)s as New Alternatives for CO2 Capture
Authors: Privalova Elena I. , Karjalainen Erno , Nurmi Mari , Mäki‐Arvela Päivi , Eränen Kari , Tenhu Heikki , Murzin Dmitry Yu. , Mikkola Jyri‐Pekka 
Published: July 2013

AbstractSolid imidazolium‐based poly(ionic liquid)s with variable molecular weights that contain the poly[2‐(1‐butylimidazolium‐3‐yl)ethyl methacrylate] (BIEMA) cation and different counter anions were evaluated in terms of CO2 capture and compared with classical ionic liquids with similar counter anions. In addition to poly(ionic liquid)s with often‐applied ions such as BF4−, PF6−, NTf2−, trifluoromethanesulfonate (OTf−) and Br−, for the first time [BIEMA][acetate] was synthesised, which revealed a remarkably high CO2 sorption performance that exceeded the poly(ionic liquid)s studied previously on average by a factor of four (12.46 mg gPIL−1). This study provides an understanding of the factors that affect CO2 sorption and a comparison of the CO2 capture efficiency with the frequently used sorbents. Moreover, all the studied sorbents were reusable if regenerated under carefully selected conditions and can be considered as suitable candidates for CO2 sorption.
Custom‐Made Morphologies of ZnO Nanostructured Films Templated by a Poly(styrene‐block‐ethylene oxide) Diblock Copolymer Obtained by a Sol–Gel Technique
Authors: Sarkar Kuhu , Rawolle Monika , Herzig Eva M. , Wang Weijia , Buffet Adeline , Roth Stephan V. , Müller‐Buschbaum Peter 
Published: July 2013

AbstractZinc oxide (ZnO) nanostructured films are synthesized on silicon substrates to form different morphologies that consist of foamlike structures, wormlike aggregates, circular vesicles, and spherical granules. The synthesis involves a sol–gel mechanism coupled with an amphiphilic diblock copolymer poly(styrene‐block‐ethylene oxide), P(S‐b‐EO), which acts as a structure‐directing template. The ZnO precursor zinc acetate dihydrate (ZAD) is incorporated into the poly(ethylene oxide) block. Different morphologies are obtained by adjusting the weight fractions of the solvents and ZAD. The sizes of the structure in solution for different sol–gels are probed by means of dynamic light scattering. Thin‐film samples with ZnO nanostructures are prepared by spin coating and solution casting followed by a calcination step. On the basis of various selected combinations of weight fractions of the ingredients used, a ternary phase diagram is constructed to show the compositional boundaries of the investigated morphologies. The evolution and formation mechanisms of the morphologies are addressed in brief. The surface morphologies of the ZnO nanostructures are studied with SEM. The inner structures of the samples are probed by means of grazing incidence small‐angle X‐ray scattering to complement the SEM investigations. XRD measurements confirm the crystallization of the ZnO in the wurtzite phase upon calcination of the nanocomposite film in air. The optical properties of ZnO are analyzed by FTIR and UV/Vis spectroscopy.
Heat stress but not inbreeding affects offensive sperm competitiveness in Callosobruchus maculatus
Authors: van Lieshout Emile , Tomkins Joseph L. , Simmons Leigh W. 
Published: July 2013

AbstractEnvironmental and genetic stress have well‐known detrimental effects on ejaculate quality, but their concomitant effect on male fitness remains poorly understood. We used competitive fertilization assays to expose the effects of stress on offensive sperm competitive ability in the beetle Callosobruchus maculatus, a species where ejaculates make up more than 5% of male body mass. To examine the effects of environmental and genetic stress, males derived from outcrosses or sib matings were heat shocked at 50°C for 50 min during the pupal stage, while their siblings were maintained at a standard rearing temperature of 28°C. Heat‐shocked males achieved only half the offensive paternity success of their siblings. While this population exhibited inbreeding depression in body size, sperm competitiveness was unaffected by inbreeding, nor did the effect of heat shock stress on sperm competitiveness depend on inbreeding status. In contrast, pupal emergence success was increased by 34% among heat‐stressed individuals, regardless of their inbreeding status. Heat‐shocked males' ejaculate size was 19% reduced, but they exhibited 25% increased mating duration in single mating trials. Our results highlight both the importance of stress in postcopulatory sexual selection, and the variability among stressors in affecting male fitness.
Landscape heterogeneity drives intra‐population niche variation and reproduction in an arctic top predator
Authors: L'Hérault Vincent , Franke Alastair , Lecomte Nicolas , Alogut Adam , Bêty Joël 
Published: July 2013

AbstractWhile intra‐population variability in resource use is ubiquitous, little is known of how this measure of niche diversity varies in space and its role in population dynamics. Here we examined how heterogeneous breeding environments can structure intra‐population niche variation in both resource use and reproductive output. We investigated intra‐population niche variation in the Arctic tundra ecosystem, studying peregrine falcon (Falco peregrinus tundrius,White) breeding within a terrestrial‐marine gradient near Rankin Inlet, Nunavut,Canada. Using stable isotope analysis, we found that intra‐population niches varied at the individual level; we examined within‐nest and among‐nest variation, though only the latter varied along the terrestrial‐marine gradient (i.e., increased among‐nest variability among birds nesting within the marine environment, indicating higher degree of specialization). Terrestrial prey species (small herbivores and insectivores) were consumed by virtually all falcons. Falcons nesting within the marine environment made use of marine prey (sea birds), but depended heavily on terrestrial prey (up to 90% of the diet). Using 28‐years of peregrine falcon nesting data, we found a positive relationship between the proportion of terrestrial habitat surrounding nest sites and annual nestling production, but no relationship with the likelihood of successfully rearing at least one nestling reaching 25 days old. Annually, successful inland breeders raised 0.47 more young on average compared to offshore breeders, which yields potential fitness consequences for this long‐living species. The analyses of niche and reproductive success suggest a potential breeding cost for accessing distant terrestrial prey, perhaps due to additional traveling costs, for those individuals with marine nest site locations. Our study indicates how landscape heterogeneity can generate proximate (niche variation) and ultimate (reproduction) consequences on a population of generalist predator. We also show that within‐individual and among‐individual variation are not mutually exclusive, but can simultaneously arise and structure intra‐population niche variation.