bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heart involvement in patients with systemic sclerosis—what have we learned about it in the last 5 years
Authors: Nadel Aleksandra , Nadel Maciej , Taborska Nina , Stępień Bartosz , Gajdecki Jakub , Brzezińska Olga , Opinc-Rosiak Aleksandra , Makowska Joanna , Lewandowska-Polak Anna 
Published: August 2024

AbstractThis review provides a detailed examination of original research and previously published reviews regarding cardiovascular involvement in systemic sclerosis (SSc). Our study aims to evaluate the current understanding of SSc-associated heart involvement (SHI), focusing on its most prevalent forms, diagnostic methods and treatment options. A comprehensive search of PUBMED, Medline, Web of science, Scopus and DOAJ databases was conducted, involving articles published between January 2019 and August 2024, available in English, both original research and reviews. Additionally, the authors examined the references cited in the selected articles, reviewed relevant literature, and included key publications dating back to 2010. Systemic Sclerosis (SSc) is an autoimmune connective tissue disease characterized by skin and internal organs fibrosis with accompanying vasculopathy. SHI encompasses both primary and secondary cardiac disease with a prevalence rate of up to 39%. It constitutes one of the leading causes of death among affected individuals. Systemic sclerosis- primary heart involvement comprises a wide range of conditions including arrhythmias, heart failure, pericardial disease, valvular abnormalities, and myocardial inflammation. However, its subclinical course, often misinterpreted as other forms of cardiomyopathy, poses true diagnostic challenges, requiring diagnostic tools like transthoracic echocardiography with tissue Doppler echocardiography and cardiac magnetic resonance imaging. The review underscores the importance of SHI and a holistic approach to managing patients with systemic sclerosis. Furthermore, it emphasizes the need for further investigation into potential pathogenetic mechanisms and biomarkers crucial for targeted treatment to fully optimize recommendations for this patient subgroup.
Aberrant p53 immunostaining patterns in breast carcinoma of no special type strongly correlate with presence and type of TP53 mutations
Authors: Armbruster Hannes , Schotte Tilman , Götting Isabell , Overkamp Mathis , Granai Massimo , Volmer Lea Louise , Bahlinger Veronika , Matovina Sabine , Koch André , Dannehl Dominik , Engler Tobias , Hartkopf Andreas D. , Brucker Sara Y. , Bonzheim Irina , Fend Falko , Staebler Annette , Montes-Mojarro Ivonne 
Published: August 2024

AbstractRecent studies have revealed an association between TP53 mutations and endocrine resistance in hormone receptor-positive, HER2-negative breast cancer (HR + HER2 −BC). Aberrant p53 immunostaining (IHC) patterns may provide a surrogate marker for TP53 mutations. Building upon a ternary algorithm of aberrant staining patterns, this study evaluates the reliability of p53 IHC as screening tool for TP53 mutations in BC (NST). Furthermore, it describes the histopathological and molecular characteristics of TP53-mutated cases, along with the mutational status of PIK3CA. This study comprised 131 early-stage, node-negative BCs with available core biopsies and resection specimens. Cases were categorized as follows: HR + HER2 − (85 cases), HER2 + (21 cases) and triple negative (TN, 25 cases). Aberrant IHC staining patterns for p53 were defined as overexpression (OE), complete absence (CA) and cytoplasmic (CY). In addition, targeted sequencing of TP53 and PIK3CA genes was performed. TP53 mutations were identified in 53 of 126 cases (42.1%). Within HR + HER2 − cases, TP53 mutations were found in 17 of 80 cases (21.3%). IHC accurately predicted TP53 mutation in 96.2% of cases with a specificity of 100%. Additionally, there was a significant agreement between missense mutations and OE, as well as between truncating mutations and CA (κ 73% and 76%). CY was observed in two TN cases with truncating mutations within the nuclear localization signalling domain of p53. TP53-mutated cases exhibited higher grade, greater nuclear pleomorphism and higher Ki-67 proliferation index and were associated with the PIK3CA wild-type status (p < 0.001). p53 IHC may provide a useful screening tool for identifying TP53-mutated BC of NST.
Exploring the role of smallholder perceptions in shaping land-use decisions in a tropical agro-forest frontier in southern Mexico
Authors: Berget Carolina , Verschoor Gerard , García-Frapolli Eduardo , Bongers Frans 
Published: August 2024

AbstractConversion of tropical forests into agricultural lands is increasing at a rapid pace. Smallholders are responsible for most of the world’s agricultural production, and thus are important land-use decision-makers and land-use change actors. In agro-forest frontiers, land-use changes are dynamic and short-term, and highly influenced by different social-ecological factors. We employed the Photovoice methodology to assess how the perceptions of 20 smallholder families about what they most value in their daily lives, influence farm land-use decisions in two villages in southern Mexico. Results indicate that what farmers perceive as the most valued in their daily lives are the household (including family and food) and the farm. Similar perceptions sometimes result in similar farm land-use composition (land-use type and proportion) decisions (agriculture, reforestation), but sometimes not (pasture, forest). Positive and negative perceptions about oil palm highly influence whether this land-use is adopted or not. In contrast, positive perceptions about rubber do not always translate in this crop being planted. We conclude that perceptions play an important role in smallholder land-use decisions. However, perceptions are influenced and operate along other factors at multiple levels, including survival motivations, culture, economic considerations, markets, farm size, institutional programs, local ecological knowledge, ecosystem services, and risk assessment. We suggest that smallholder perceptions should be taken into account as part of the set of social-ecological factors driving land-use decisions. Involving farmers in the co-design of land-use policies, planning, and rural development initiatives that address their perceptions, values, and livelihood needs will improve the effectiveness of such policies.
Changes in evaporation patterns and their impact on Climatic Water Balance and river discharges in central Poland, 1961–2020
Authors: Bartczak Arkadiusz , Krzemiński Michał , Araźny Andrzej 
Published: August 2024

AbstractThis study investigates the changes in precipitation and evaporation patterns and their impact on Climatic Water Balance and river discharges in central Poland from 1961 to 2020. The analysis focuses on two “normal” periods, 1961–1990 and 1991–2020 (according to the World Meteorological Organization). Bartlett’s test and the Kruskal–Wallis rank sum test were used to assess the homogeneity of variances and compare distributions of analyzed variables over two “normal” periods. The probability density functions were estimated using a kernel density estimator with a Gaussian kernel function. Significant findings indicate alterations in evaporation rates and shifts in water balance dynamics. Mean evaporation increased from 530.8 to 637.9 mm, leading to a notable decrease in the mean Climatic Water Balance from 1.1 to − 107.5 mm (in the periods 1961–1990 and 1991–2020, respectively). Additionally, rivers showed reduced mean annual discharges (from 4.28 to 3.01 m3·s−1 and 1.25 to 0.87 m3·s−1, for the Zgłowiączka and Skrwa Lewa rivers, respectively). These climatic changes in central Poland have substantial implications for regional water resources, especially in spring and summer and particularly in agricultural areas, potentially exacerbating drought conditions and impacting agricultural productivity mainly in the warm half-year.
Evaluating the Link between Visual Attention Bias and Emotion Dysregulation of Young Children
Authors: Brice Febe , Lam-Cassettari Christa , Gerstl Brigitte , Eapen Valsamma , Lin Ping-I. 
Published: August 2024

AbstractThe ability to regulate emotions is vital to successful social interactions. This study explores whether visual attention bias is associated with emotion dysregulation (ED) in early childhood. Parental reports of child ED (Child Behaviour Checklist (CBCL) and Temper Tantrum Scale) were examined in relation to child visual attention bias whilst viewing emotional faces. Results indicated that the level of eye gaze fixation towards emotional images and faces was associated with ED when social function (measured with the Social Responsiveness Scale), gender, age, and attention problems (measured from the CBCL subscale), were adjusted. The modifying effect on visual attention bias was evaluated using interaction analysis in the generalized linear model. The level of visual attention bias, indicated by the proportion of eye gaze fixation time on areas of interest (AOIs) in images displaying unpleasant emotions (such as anger), was inversely associated with the level of externalising problem behaviours (p = .014). Additionally, the association of eye gaze fixation time for AOIs displaying negative emotional cues with the level of externalising problem behaviours varied by age (p = .04), with younger children (aged < 70 months) demonstrating a stronger association than older children (aged $$\ge$$
≥
70 months). Findings suggest that young children with greater ED symptoms look less at unpleasant emotional cues. However, this relationship is attenuated as children become older. Further research to identify objective biomarkers that incorporate eye-tracking tasks may support prediction of ED-related mental health issues in the early years.
Single cell, Label free Characterisation of Human Mesenchymal Stromal cell Stemness and Future Growth Potential by Autofluorescence Multispectral Imaging
Authors: Campbell Jared M. , Habibalahi Abbas , Agha Adnan , Handley Shannon , Knab Aline , Xu Xiaohu , Bhargava Akanksha , Lei Zhilin , Mackevicius Max , Tian Yuan , Mahbub Saabah B. , Anwer Ayad G. , Gronthos Stan , Paton Sharon , Grey Shane T. , Wu Lindsay , Gilchrist Robert B. , Goldys Ewa M. 
Published: August 2024

Abstract
Aim
To use autofluorescence multispectral imaging (AFMI) to develop a non-invasive assay for the in-depth characterisation of human bone marrow derived mesenchymal stromal cells (hBM-MSCs).

Methods
hBM-MSCs were imaged by AFMI on gridded dishes, stained for endpoints of interest (STRO-1 positivity, alkaline phosphatase, beta galactosidase, DNA content) then relocated and results correlated. Intensity, texture and morphological features were used to characterise the colour distribution of regions of interest, and canonical discriminant analysis was used to separate groups. Additionally, hBM-MSC lines were cultured to arrest, with AFMI images taken after each passage to investigate whether an assay could be developed for growth potential.

Results
STRO-1 positivity could be predicted with a receiver operator characteristic area under the curve (AUC) of 0.67. For spontaneous differentiation this was 0.66, for entry to the cell-cycle it was 0.77 and for senescence it was 0.77. Growth potential (population doublings remaining) was estimated with an RMSPE = 2.296. The Mean Absolute Error of the final prediction model indicated that growth potential could be predicted with an error of ± 1.86 doublings remaining.

Conclusions
This non-invasive methodology enabled the in-depth characterisation of hBM-MSCs from a single assay. This approach is advantageous for clinical applications as well as research and stands out for the characterisation of both present status as well as future behaviour. The use of data from five MSC lines with heterogenous AFMI profiles supports potential generalisability.

Graphical Abstract
Feynman formulas for qp- and pq-quantization of some Vladimirov type time-dependent Hamiltonians on finite adeles
Authors: Urban Roman 
Published: August 2024

AbstractLetQbe thed-dimensional space of finite adeles over the algebraic number fieldKand let$$P=Q^*$$P=Q∗be its dual space. For a certain type of Vladimirov type time-dependent Hamiltonian$$H_V(t):Q\times P\rightarrow {\mathbb {C}}$$HV(t):Q×P→Cwe construct the Feynman formulas for the solution of the Cauchy problem with the Schrödinger operator "Equation missing"where the caret operator stands for theqp- orpq-quantization.
Big Disaster from Small Watershed: Insights into the Failure and Disaster-Causing Mechanism of a Debris Flow on 25 September 2021 in Tianquan, China
Authors: Hou Runing , Wu Mingyang , Li Zhi , Chen Ningsheng , Chen Xiaohu , Peng Taixin , Huang Na 
Published: August 2024

AbstractThe occurrence of debris flow events in small-scale watersheds with dense vegetation in mountainous areas that result in significant loss of life and missing individuals challenges our understanding and expertise in investigating and preventing these disasters. This has raised concerns about the occurrence of large debris flow disasters from small watersheds. This study focused on a catastrophic debris flow that took place in Longtou Gully (0.45 km2) in Tianquan County, Ya’an City on 25 September 2021, which resulted in 14 deaths and missing individuals. Through comprehensive field investigations, high-precision remote sensing data analyses, and numerical simulations, we analyzed the triggering mechanisms and dynamic processes of this event. Our results indicate that the convergence hollow at the channel head exhibited higher hydraulic conditions during rainfall compared to gentle slopes and convex terrains, leading to the instability of colluvial soil due to the expansion of the saturated zone near the soil–bedrock interface. The entrainment of material eroded from the channel resulted in an approximately 4.7 times increase in volume, and the channel scarp with a height of about 200 m amplified the destructive power of the debris flow. We emphasize the need to take seriously the possibility of catastrophic debris flows in small-scale watersheds, with colluvial deposits in hollows at the channel head under vegetation cover that serve as precursor material sources, and the presence of channel scarps formed by changes in the incision rate of the main river, which is common in the small watershed on both sides. This study provides insights for risk assessment of debris flows in small-scale catchments with dense vegetation cover in mountainous areas, highlighting the importance of vigilance in addressing disasters in small-scale catchments, particularly in regions with increasing human–environment conflicts.
Protection of Press Publishers in the Age of Generative AI – In Search of Legal Remedies to Adapt to the Pace of Technology
Authors: Kowala Michalina 
Published: August 2024

AbstractHas everything already been said on the protection of press publishers? Surely not, and this is due to the new challenges for the press sector posed by Generative AI. This paper aims to discuss the solutions adopted in EU copyright law to safeguard the legal situation of press publishers in the face of the development of Generative AI. It identifies the shortcomings in existing forms of protection and proposes legal remedies for those shortcomings. It offers a fresh perspective on and insights into the new challenges posed by Generative AI, especially regarding its training phase. It explores the approach taken by EU legislation, and also makes reference to solutions proposed in the United States. The objective of this paper is to strike a balance between the need to ensure proper conditions for innovation and the need to protect human creativity and the dissemination thereof. It seeks to contribute to the ongoing debate on copyright and AI by assessing how the current copyright framework suits the development of Generative AI, identifying gaps in protection and paving the way for necessary legal changes in a context of transparency, compensation for use of protected content for AI training purposes, and preservation of rights.
Reducing Load Transfer to Buried Pipes Through Coupled Use of Geogrid Reinforcement and Sand Rubber Zone in the Backfill Material
Authors: Elshesheny Ahmed , Aljaberi Mohammad , Almanea Sara , Mohamed Mostafa 
Published: August 2024

AbstractA laboratory study, consisting of 21 tests, was conducted to examine precisely the impact of using a sand-rubber mixture with three different ratios of rubber (3, 5, and 7%) in a particular zone within the backfill and a geogrid reinforcement on the pressure transferred to buried pipes from surface loads. The pipe was buried at two different burial depths of 1.5 and 2 times the pipe diameter. Tests were conducted with a geogrid-reinforcement layer placed above and below the sand-rubber zone to determine the optimal performance of the proposed system. The findings from these tests are expected to contribute valuable insights into the development of effective strategies for reducing the impact on buried pipes and enhancing their overall resilience, particularly in the face of increasing surface loading. The results revealed that using a rubber ratio of 5% would present the optimum rubber ratio and using a geogrid layer above the sand-rubber zone would provide additional stability, where the bearing capacity of the system was increased by 33.7%, independent of the pipe burial depth and rubber ratio. Furthermore, the use of a sand-rubber mixture and a geogrid layer contributed to decreasing the pressure transferred to the pipe crown and the deformation of the soil surface, respectively.
A new extension of the EDAS method in a fuzzy environment for group decision-making
Authors: Kacprzak Dariusz 
Published: August 2024

AbstractThe complexity of the decision-making problems being analysed has led to the development of multiple multi-criteria decision-making (MCDM) methods. One of the more recent methods belonging to this group is the evaluation based on distance from average solution (EDAS) method. To date, it has found extensive use in solving real-world decision-making problems and has seen many extensions to input data types other than real numbers. One of these is the EDAS method for group decision-making in a fuzzy environment. This method aggregates individual evaluations of decision-makers into a group evaluation using the arithmetic mean. This may result in equal group ratings despite the variety of individual ratings, making it difficult or even impossible to rank alternatives because the EDAS algorithm will be blocked. The paper proposes a new fuzzy extension of EDAS called the PFEDAS method for group decision-making. The main difference between the proposed method and the original one is that at the initial stage the individual decision matrices are not aggregated into a group matrix but are transformed into matrices of alternatives. As a result, the new PFEDAS method is based on the initial data instead of their averaged values which allows a more accurate comparison of alternatives. Using a numerical example, the PFEDAS method is compared with other similar methods known from the literature.
Weight in the Workplace: Weight Discrimination Impacts Professional Outcomes as a Function of Social Pain Minimization
Authors: Johnson Brielle N. , Hunger Jeffrey M. , Sawhney Gargi , Kunstman Jonathan W. 
Published: August 2024

AbstractWorkplace weight discrimination is pervasive and harms both individuals and organizations. However, despite its negative effects on employees and employers, the social and psychological processes linking weight discrimination and workplace outcomes remain unclear. Rooted in evidence that people regularly dehumanize and dismiss the emotions of heavier individuals, the current work tests one socioemotional pathway linking workplace weight discrimination and professional outcomes: social pain minimization (SPM). SPM refers to feelings of emotion invalidation when people share negative social experiences with others and feel their hurts are discounted and dismissed by their colleagues. Across two studies using cross-sectional and prospective designs (Ntotal = 661), the current work provides evidence that workplace weight discrimination increased feelings of SPM, which in turn was associated with greater burnout, lower job satisfaction, and more counterproductive work behaviors. In the wake of workplace weight discrimination, subsequent SPM negatively affects workplace outcomes. For those experiencing workplace weight discrimination, mistreatment and invalidation frequently operate as a one-two punch to critical organizational outcomes.
Der Behandlungsprozess von Kindern und Jugendlichen mit Geschlechtsinkongruenz/Geschlechtsdysphorie in Österreich
Authors: Klinger Diana , Oehlke Sofia-Marie , Bründlmayer Anselm , Zesch Heidi Elisabeth , Riedl Stefan 
Published: August 2024

ZusammenfassungMit den gegenwärtigen gesellschaftlichen Veränderungen rückt das Thema Geschlechtsidentität und Geschlechtsausdruck zunehmend in den Vordergrund. Insbesondere Kinder und Jugendliche stehen bei der Auseinandersetzung mit ihrer Geschlechtsidentität oft vor komplexen Herausforderungen. Daher ist es essenziell, dass sie auf diesem Weg umfassende Unterstützung und Verständnis erfahren. In Österreich verfolgt der Behandlungsprozess für Kinder und Jugendliche mit Geschlechtsinkongruenz/Geschlechtsdysphorie einen ganzheitlichen und interdisziplinären Ansatz, der darauf abzielt, die individuellen Bedürfnisse der Kinder und Jugendlichen zu erkennen und gezielt zu adressieren. Die aktuell gültigen „Empfehlungen für den Behandlungsprozess bei Geschlechtsdysphorie von Kindern und Jugendlichen nach der Klassifikation in der derzeit gültigen DSM- bzw. ICD-Fassung“ dienen hierbei als zentrale Orientierungshilfe. Diese Leitlinie enthält detaillierte Empfehlungen zur Behandlung von Kindern und Jugendlichen und unterstützt Fachkräfte dabei, eine umfassende Diagnostik und individuell angepasste Therapie sicherzustellen. Ziel ist es, durch ein integratives Betreuungskonzept die psychische und physische Gesundheit der jungen Menschen zu fördern, wobei das Wohlbefinden und die Lebensqualität nachhaltig verbessert werden sollen.