bluuebunny/crossref_metadata_2025_split huggingface dataset:
The human rs1050286 polymorphism alters LOX‐1 expression through modifying miR‐24 binding
Authors: Morini Elena , Rizzacasa Barbara , Pucci Sabina , Polidoro Chiara , Ferrè Fabrizio , Caporossi Daniela , Helmer Citterich Manuela , Novelli Giuseppe , Amati Francesca 
Published: November 2015

AbstractThe up‐regulation of lectin‐like oxidized low‐density lipoprotein receptor‐1 (LOX‐1), encoded by the OLR1 gene, plays a fundamental role in the pathogenesis of atherosclerosis. Moreover, OLR1 polymorphisms were associated with increased susceptibility to acute myocardial infarction (AMI) and coronary artery diseases (CAD). In these pathologies, the identification of therapeutic approaches that can inhibit or reduce LOX‐1 overexpression is crucial. Predictive analysis showed a putative hsa‐miR‐24 binding site in the 3′UTR of OLR1, ‘naturally’ mutated by the presence of the rs1050286 single nucleotide polymorphism (SNP). Luciferase assays revealed that miR‐24 targets OLR1 3′UTR‐G, but not 3′UTR‐A (P < 0.0005). The functional relevance of miR‐24 in regulating the expression of OLR1 was established by overexpressing miR‐24 in human cell lines heterozygous (A/G, HeLa) and homozygous (A/A, HepG2) for rs1050286 SNP. Accordingly, HeLa (A/G), but not HepG2 (A/A), showed a significant down‐regulation of OLR1 both at RNA and protein level. Our results indicate that rs1050286 SNP significantly affects miR‐24 binding affinity to the 3′UTR of OLR1, causing a more efficient post‐transcriptional gene repression in the presence of the G allele. On this basis, we considered that OLR1 rs1050286 SNP may contribute to modify OLR1 susceptibility to AMI and CAD, so ORL1 SNPs screening could help to stratify patients risk.
Predictors of depressive symptoms in older Japanese primiparas at 1 month post‐partum: A risk‐stratified analysis
Authors: Iwata Hiroko , Mori Emi , Tsuchiya Miyako , Sakajo Akiko , Maehara Kunie , Ozawa Harumi , Morita Akiko , Maekawa Tomoko , Aoki Kyoko , Tamakoshi Koji 
Published: November 2015

AbstractAimOlder maternal age has become more common in Japan. Studies suggest that older maternal age and primiparity are associated with post‐partum depression. The present study aimed to identify predictors of post‐partum depression in older Japanese primiparas at 1 month post‐partum.MethodsParticipants were 479 primiparas aged 35 years and over, drawn from a prospective cohort study. Data were collected using self‐report questionnaires. Depression was measured with the Japanese version of the Edinburgh Postnatal Depression Scale. Stepwise logistic regression analysis was conducted on binary outcome variables of depression at 1 month post‐partum, along with a stratified analysis based on the risk status of depression.ResultsFive predictors were identified: (i) the depression score during hospital stay; (ii) financial burden; (iii) dissatisfaction with appraisal support; (iv) physical burden in daily life; and (v) concerns about infant caretaking. Stratified analysis identified dissatisfaction with instrumental support in the low‐risk group, and the Child‐care Value Scale score as unique predictors in the high‐risk group.ConclusionThese results highlight the importance of early assessment of depressive symptoms and the provision of continuous care.
Nurse occupational burnout and patient‐rated quality of care: The boundary conditions of emotional intelligence and demographic profiles
Authors: Chao Minston , Shih Chih‐Ting , Hsu Shu‐Fen 
Published: November 2015

AbstractAimMost previous studies on the relationship between occupational burnout and the quality of care among nurses have used self‐reported data on the quality of care from nurses, thus rendering evaluating the relationship between burnout and the quality of care difficult. Hospitals increasingly hire contract nurses and high turnover rates remain a concern. Little is known about whether nurses' emotional intelligence and demographic factors such as contract status, tenure, and marital status affect the quality of care when burnout occurs. This study investigated the relationship between burnout and patient‐rated quality of care and investigated the moderating role of emotional intelligence and demographic variables.MethodsHierarchical moderated regression was used to analyze 98 sets of paired data obtained from nurses and their patients at a teaching hospital in northern Taiwan.ResultsThe results suggest that occupational burnout has a less unfavorable effect on the quality of care from permanent, married, and senior nurses.ConclusionNursing management should pay particular attention to retaining permanent, married, and senior nurses. To ensure a sustainable nursing workforce in the future, newly graduated registered nurses should have access to permanent positions and opportunities for long‐term professional development. In addition, married nurses should be provided with flexible work–family arrangements to ensure their satisfaction in the nursing profession.
Effectiveness of patient navigator interventions on uptake of colorectal cancer screening in primary care settings
Authors: Muliira Joshua Kanaabi , D'Souza Melba Sheila 
Published: November 2015

AbstractAimColorectal cancer is the fourth most common type of cancer in the world and every year it is responsible for 610,000 deaths worldwide. The aim of this review was to examine the effectiveness of patient navigator interventions towards enhancing uptake of colorectal cancer screening in primary care settings.MethodsElectronic databases such as PubMed, CINHAL, Google Scholar and SCOPUS were searched to retrieve articles reporting on primary studies applying any patient navigator intervention to promote uptake of colorectal cancer screening in eligible patients. The search yielded 292 articles and 15 met the inclusion criteria.ResultsAll 15 studies were conducted in urban settings located in the USA. The findings of the review show that patient navigator interventions can increase colorectal cancer screening rates in diverse primary care settings. Patient navigator interventions were most effective in patients who belong to minority groups and enhanced uptake of colorectal cancer screening with rates ranging 11–91%.ConclusionThere is a need for further studies to examine the effectiveness of patient navigator interventions in rural populations and other countries. Such studies will help us to clearly characterize the effectiveness of patient navigator interventions.
Effect of Naftopidil on Bladder Microcirculation in a Rat Model of Bladder Outlet Obstruction
Authors: MAJIMA Tsuyoshi , YAMAMOTO Tokunori , FUNAHASHI Yasuhito , TAKAI Shun , MATSUKAWA Yoshihisa , YOSHIDA Masaki , GOTOH Momokazu 
Published: November 2015

ObjectivesTo evaluate the effect of naftopidil on bladder capillary blood flow using bladder outlet obstruction model rats.MethodsFemale Sprague–Dawley rats were divided into three groups: control group, bladder‐outlet‐obstruction group, and bladder‐outlet‐obstruction + naftopidil group. Bladder‐outlet‐obstruction surgery was performed in the bladder‐outlet‐obstruction and bladder‐outlet‐obstruction + naftopidil groups. The control group received sham‐operation. The bladder‐outlet‐obstruction + naftopidil group were treated with naftopidil (30 mg/kg) for 14 days after bladder‐outlet‐obstruction operation, while the control and bladder‐outlet‐obstruction groups were treated with vehicle. Continuous cystometry was performed 14 days after the surgery. Bladder blood flow was measured after 14 days using a pencil lens charge‐coupled device microscopy system. The bladder was then harvested for histology and measuring 8‐hydroxy‐2′‐deoxyguanosine tissue level by enzyme‐linked immunosorbent assay.ResultsIn cystometry, the bladder‐outlet‐obstruction rats showed bladder overactivity, while naftopidil treatment improved the cystometric pattern. The blood flow through the submucosal capillaries of the bladder base in the bladder‐outlet‐obstruction group was lesser than that in the control, whereas the bladder‐outlet‐obstruction + naftopidil group showed significantly greater blood flow than the bladder‐outlet‐obstruction group. The bladder tissue in the bladder‐outlet‐obstruction group showed a tendency to contain more hypertrophic detrusor muscle and inflammatory cells compared to those in the control group, while naftopidil treatment suppressed these histological changes. The 8‐hydroxy‐2′‐deoxyguanosine levels in the bladder tissue significantly differed among the three groups (the bladder‐outlet‐obstruction group > the bladder‐outlet‐obstruction + naftopidil group > the control group).ConclusionsNaftopidil improved bladder overactivity as well as the impaired bladder blood flow.caused by bladder‐outlet‐obstruction.
Post‐radiation fibrosarcoma of the cerebrum associated with a prominent, lace‐like, perivascular, desmoplastic change
Authors: Shintaku Masayuki , Adachi Yasushi , Takeuchi Yasuhide , Yamamoto Daisuke , Koyama Junji 
Published: November 2015

AbstractAn intra‐axial tumor measuring about 4 cm was excised from the right temporal lobe of a 35‐year‐old woman, who had a past history of resection of craniopharyngioma and postoperative radiation 21 years earlier. The tumor involved both the cortex and white matter, but was not attached to the dura mater. It consisted of a dense, interlacing, fascicular proliferation of atypical fibroblastic cells and was associated with an extensive, lace‐like, desmoplastic change mainly involving the perivascular region around the tumor and overlying the subarachnoid space. The histopathological features of the desmoplastic change resembled meningioangiomatosis, but no proliferation of meningothelial cells was noted. The patient has been free from recurrence for 12 months since the operation. The association of primary cerebral fibrosarcoma with an extensive, lace‐like, perivascular, desmoplastic change has not been documented in the literature. The radiation administered 21 years previously may have played some pathogenetic role in the perivascular desmoplastic change, and a malignant transformation of fibroblasts within the perivascular collagenous tissue is considered the most likely origin of the fibrosarcoma.
Is There Catch‐Up Growth? Evidence from Three Continents
Authors: Handa Sudhanshu , Peterman Amber 
Published: November 2015

AbstractThe ability to correct deficiencies in early childhood malnutrition, what is known as catch‐up growth, has widespread consequences for economic and social development. While clinical evidence of catch‐up has been observed, less clear is the ability to correct for chronic malnutrition found in impoverished environments in the absence of extensive and focused interventions. This paper investigates whether nutritional status at early age affects nutritional status a few years later among children, using panel data from China, South Africa and Nicaragua. The key research question is the extent to which state dependence in linear growth exists among young children, and what family and community level factors mediate state dependency. The answer to this question is crucial for public policy due to the long‐term economic consequences of poor childhood nutrition. Results show strong but not perfect persistence in nutritional status across all countries, indicating that catch‐up growth is possible though unobserved household behaviours tend to worsen the possibility of catch‐up growth. Public policy that can influence these behaviours, especially when children are under 24 months old, can significantly alter nutrition outcomes in South Africa and Nicaragua.
Back to the Unchanging Past
Authors: Baron Sam 
Published: November 2015

AbstractThe standard philosophical view of time travel has it that time travelers cannot change the past. It has been argued by some that the standard view is false, and that this can be shown using a two‐dimensional model of time. I defend the standard view against this attack. I show, first, that the addition of a second temporal dimension does not provide a model of changing the past and, second, that neither does the addition of n temporal dimensions for any n > 1.
Risperidone, quetiapine and chlorpromazine may have induced priapism in an adolescent
Authors: Baytunca Muharrem Burak , Kose Sezen , Ozbaran Burcu , Erermis Serpil 
Published: November 2015

AbstractPriapism is the prolonged, painful erection of penile tissue not accompanied by sexual arousal. Priapism has been established as a rare adverse drug reaction to drugs such as antipsychotics, psychostimulants, antidepressants, and mood stabilizers. Immediate intervention is needed to prevent destructive and irreversible complications, such as erectile dysfunction, disfigurement, inability of the penis to stay erect, and related social/emotional problems. Antipsychotic‐induced priapism may result from the alpha receptor occupancy property of those drugs. We report the case of a 13‐year‐old suffering from attention deficit–hyperactivity disorder plus conduct disorder with priapism related to antipsychotics. Episodes occurred with risperidone plus methylphenidate, quetiapine plus methylphenidate, and chlorpromazine alone.
Primary renal neuroblastoma with metastasis and matrix metalloproteinase‐14 expression
Authors: Zenitani Masahiro , Uehara Shuichiro , Miyashita Emiko , Hashii Yoshiko , Oue Takaharu , Okuyama Hiroomi 
Published: November 2015

AbstractWe herein report the rare case of a 4‐year–5‐month‐old boy who presented with primary renal neuroblastoma. The patient developed repeated lung and liver metastatic recurrences, but, following a combination of chemotherapy, radiation therapy and aggressive surgical resection, the patient is now in remission. To investigate the pathogenesis of lung metastasis, immunohistochemistry was performed for matrix metalloproteinase‐9 and ‐14 (MMP‐9 and MMP‐14), molecular markers of invasion, metastasis and angiogenesis in neuroblastoma. In the present case, MMP‐9 expression was not observed, but MMP‐14 expression was detected in the primary lesion and was more highly expressed in the metastatic lesion compared with the primary one. Given the MMP‐14 staining in other cases, expression of MMP‐14 may be associated with the aggressiveness of the tumor. This suggests that selected clones with high MMP‐14 expression in the primary tumor might metastasize and form MMP‐14‐rich lesions.
Tick‐borne encephalitis in a child with previous history of completed primary vaccination
Authors: Zlamy Manuela , Haberlandt Edda , Brunner Jürgen , Dozcy Ludwig , Rostasy Kevin 
Published: November 2015

AbstractWe report the case of a 13‐year‐old girl who presented with fever, headache, nausea and pain behind the right ear. Cerebrospinal fluid (CSF; leukocytes 227/μL), electroencephalogram and cerebral magnetic resonance imaging were indicative of meningoencephalitis. Despite intensive therapy the general condition worsened and the patient was admitted to the intensive care unit. Serological analysis of CSF and serum indicated acute tick‐borne encephalitis virus (TBEV) infection (IgG and IgM positive). TBEV infection has been reported after incomplete and complete vaccination. TBEV vaccination breakthrough in childhood has been shown to cause severe disease. It has been suggested that immunized patients develop more severe disease due to altered immune response, but the exact mechanism is unknown. In the presence of typical symptoms and a history of vaccination, possible vaccination breakthrough or missing booster vaccination should be considered.
Mutant neurogenin‐3 in a Turkish boy with congenital malabsorptive diarrhea
Authors: Ünlüsoy Aksu Aysel , Eğritaş Gürkan Ödül , Sarı Sinan , Demirtaş Zeliha , Türkyılmaz Canan , Poyraz Aylar , Dalgıç Buket 
Published: November 2015

AbstractCongenital diarrheal disorders are caused by disruption in nutrient digestion, absorption, or transport, enterocyte development and functioning, or enteroendocrine functioning. Many additional rare forms of congenital diarrhea are expected to be linked to genes associated with appropriate intestinal fluid and electrolyte balance. Neurogenin‐3 mutation, a very rare form of congenital diarrhea, disrupts enteroendocrine cell differentiation and is characterized by malabsorption and the absence of pancreatic islet cells. Diabetes mellitus is typically associated with malabsorptive diarrhea at early onset or at later presentation in neurogenin‐3 mutation. Here, we describe the case of an infant with homozygous neurogenin‐3 mutation who had severe malabsorptive diarrhea and episodes of hyperchloremic metabolic acidosis after birth. Remarkably, cholestyramine was effective at reducing stool volume and frequency and improved the consistency of the stools; diabetes was not present in this patient.
Daylight‐mediated photodynamic therapy for actinic damage in Latin America: consensus recommendations
Authors: Grinblat Beni , Galimberti Gaston , Chouela Edgardo , Sanclemente Gloria , Lopez Miguel , Alcala Daniel , Torezan Luís , Pantoja Gonzalo 
Published: November 2015

SummaryAlthough conventional photodynamic therapy (c‐PDT) using methyl aminolevulinate cream (MAL) is effective for the treatment of grade I‐II facial and scalp actinic keratosis (AK), it is associated with treatment‐related pain for some patients. Daylight‐mediated PDT (DL‐PDT) has shown similar efficacy to c‐PDT, was nearly painless, and was well tolerated. Overall, DL‐PDT effectively treats AK and offers a simpler and better tolerated treatment option than c‐PDT. This consensus panel provided recommendations on the use of DL‐PDT in Latin America (LATAM) for the treatment of actinic damage associated with few or multiple AKs. The panel was comprised of eight dermatologists from different LATAM countries who have experience using PDT for the treatment of actinic damage. The panel reviewed the relevant literature and provided personal expertise with regard to using DL‐PDT for the treatment of photodamage with or without AK. The recommendations formulated by the expert panel provide evidence‐based guidelines on all aspects of DL‐PDT for the treatment of actinic damage associated with AK in different regions of LATAM. These recommendations provide guidance for dermatologists to ensure maintenance of efficacy and safety of DL‐PDT when treating actinic damage, associated with few or multiple AKs in sun‐exposed skin.
Monetary Reference Points of Managers – Empirical Evidence of Status Quo Preferences and Social Comparisons
Authors: Grund Christian , Martin Johannes 
Published: November 2015

AbstractWe explore whether monetary reference points affect managers′ job satisfaction. These reference points include a manager′s own status quo and the incomes of comparable managers within the same firm and also at the market level. Making use of a unique panel data set of managers in the German chemical sector, we find that social comparisons of compensation do affect reported job satisfaction. Both the relative income position within a manager's own firm and a manager's wage rank on the market have positive relations with job satisfaction. There is no evidence of the relevance of status quo considerations once we control for firm‐related pay variables.
Different wound healing properties of dermis, adipose, and gingiva mesenchymal stromal cells
Authors: Boink Mireille A. , van den Broek Lenie J. , Roffel Sanne , Nazmi Kamran , Bolscher Jan G.M. , Gefen Amit , Veerman Enno C.I. , Gibbs Susan 
Published: November 2015

AbstractOral wounds heal faster and with better scar quality than skin wounds. Deep skin wounds where adipose tissue is exposed, have a greater risk of forming hypertrophic scars. Differences in wound healing and final scar quality might be related to differences in mesenchymal stromal cells (MSC) and their ability to respond to intrinsic (autocrine) and extrinsic signals, such as human salivary histatin, epidermal growth factor, and transforming growth factor beta1. Dermis‐, adipose‐, and gingiva‐derived MSC were compared for their regenerative potential with regards to proliferation, migration, and matrix contraction. Proliferation was assessed by cell counting and migration using a scratch wound assay. Matrix contraction and alpha smooth muscle actin was assessed in MSC populated collagen gels, and also in skin and gingival full thickness tissue engineered equivalents (reconstructed epithelium on MSC populated matrix). Compared to skin‐derived MSC, gingiva MSC showed greater proliferation and migration capacity, and less matrix contraction in full thickness tissue equivalents, which may partly explain the superior oral wound healing. Epidermal keratinocytes were required for enhanced adipose MSC matrix contraction and alpha smooth muscle actin expression, and may therefore contribute to adverse scarring in deep cutaneous wounds. Histatin enhanced migration without influencing proliferation or matrix contraction in all three MSC, indicating that salivary peptides may have a beneficial effect on wound closure in general. Transforming growth factor beta1 enhanced contraction and alpha smooth muscle actin expression in all three MSC types when incorporated into collagen gels. Understanding the mechanisms responsible for the superior oral wound healing will aid us to develop advanced strategies for optimal skin regeneration, wound healing and scar formation.
Mechanistic Three-Dimensional Analytical Solutions for a Direct
Liquid Fuel Cell Stack
Authors: Ling Chun Yu , Han Ming , Chen Yunzhong , Birgersson Erik 
Published: November 2015

Abstract
An optimal or near to optimal design and operation of a direct liquid fuel cell (DLFC) stack requires an understanding of the relevant physical phenomena across length scales in the stack. In particular, perturbations between cells can arise due to external manifold design as well as variations in material and design parameters between cells. In this work, we seek to derive closed-form analytical expressions that capture the global stack performance, as well as individual cell behavior such as cell potential, current density, and methanol distribution. This approach allows for the simulation of large stacks with near to negligible computational overhead. Finally, the solutions are demonstrated for a stack subjected to perturbations in the anode inlet velocity of each cell.
Does a More Centrally Located School Promote Walking to School? Spatial Centrality in School-Neighborhood Settings
Authors: Kim Hyung Jin , Lee Chanam 
Published: November 2015

Background:A public elementary school has traditionally functioned as an important center of a neighborhood, but this role has diminished with sprawling urban developments. Despite the large number of studies of children’s walking to/from school (WTS), the school’s location in relation to the larger neighborhood context has not been fully explored. This study is to examine the relationship between school’s spatial centrality and children’s WTS in urban, suburban and rural settings.Methods:this study used school travel tally (11,721 students), environment audit, GIS and census data from 71 elementary school/neighborhoods in Texas, and employed the closeness centrality index to estimate a school’s spatial centrality. Data were collected from 2009–2012.Results:After controlling for neighborhood characteristics, it was found that more centrally located schools are likely to have higher proportions of WTS in the neighborhoods. And, among urban, suburban and rural settings, urban schools were the most and rural schools were the least likely to be centrally-located in the neighborhoods.Conclusions:The findings offer implications on school and community planning policies that can help promote WTS. Spatial centrality measures can be effective tools to identify environmental factors in complex urban networks related to human behaviors and community-based activities.