bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting invasive disease-free survival in ER-positive, HER2-negative early breast cancer using the PAM50 risk-of-recurrence score: a retrospective analysis using single-center long-term follow-up data of postmenopausal Japanese patients
Authors: Higami Akane , Takada Masahiro , Kawaguchi-Sakita Nobuko , Kawashima Masahiro , Kawaguchi Kosuke , Yamaguchi Ayane , Takeuchi Yasuhide , Yamada Yosuke , Toi Masakazu 
Published: August 2024

Abstract
Background
The prognostic value of the risk-of-recurrence (ROR) score calculated using PAM50 has been validated using clinical trials and patient cohorts. This study aimed to investigate the prognostic value of the PAM50 ROR score in Japanese patients with early breast cancer using long-term follow-up data.

Methods
We enrolled postmenopausal patients with ER-positive, HER2-negative, stage I–II breast cancer who had undergone surgery at the Kyoto University Hospital between 2008 and 2014. The intrinsic subtype and ROR score were calculated using PAM50. The primary endpoint was invasive disease-free survival (IDFS).

Results
We enrolled 146 patients, of whom 47 (32%) patients had node-positive disease, and 36 (25%) had received neoadjuvant or adjuvant chemotherapy. The proportions of intrinsic subtypes for luminal A, luminal B, HER2-enriched, and basal-like subtypes were 67%, 27%, 3%, and 2%, respectively. The median follow-up duration was 8.4 (range 6.3–10.0) years, and 21 IDFS events were observed. Based on the ROR score, 37%, 33%, and 30% of the patients were classified as low, intermediate, and high risks, respectively. Patients in the high-risk group had a significantly worse 8-year IDFS rate than those in the low-to-intermediate-risk groups (75.1% vs. 91.6%, p = 0.04). The same trend was observed in patients with and without neoadjuvant or adjuvant chemotherapy.

Conclusions
Using long-term follow-up data, this study showed that the ROR score can predict the prognosis of ER-positive, HER2-negative early breast cancer in Japanese postmenopausal patients. Further investigations are required to confirm the prognostic value of the ROR score in Asian populations.
An Instrumented Hammer to Detect the Rupture of the Pterygoid Plates
Authors: Bas dit Nugues Manon , Lamassoure Leo , Rosi Giuseppe , Flouzat-Lachaniette Charles Henri , Khonsari Roman Hossein , Haiat Guillaume 
Published: August 2024

Abstract

Purpose
Craniofacial osteotomies involving pterygomaxillary disjunction are common procedures in maxillofacial surgery. Surgeons still rely on their proprioception to determine when to stop impacting the osteotome, which is important to avoid complications such as dental damage and bleeding. Our group has developed a technique consisting in using an instrumented hammer that can provide information on the mechanical properties of the tissue located around the osteotome tip. The aim of this study is to determine whether a mallet instrumented with a force sensor can be used to predict the crossing of the osteotome through the pterygoid plates.

Methods
31 osteotomies were carried out in 16 lamb skulls. For each impact, the force signal obtained was analysed using a dedicated signal processing technique. A prediction algorithm based on an SVM classifier and a cost matrix was applied to the database.

Results
We showed that the device could always detect the crossing of the osteotome, sometimes before its occurrence. The prediction accuracy of the device was 94.7%. The method seemed to be sensitive to the thickness of the plate and to crack apparition and propagation.

Conclusion
These results pave the way for the development of a per-operative decision support system in maxillofacial surgery.
The “Cycle” of HIV: Limits of Personal Responsibility in HIV Vulnerability Among Transgender Adolescents and Young Women in Lima, Peru
Authors: Orozco-Poore Casey , Perez-Brumer Amaya , Huerta Leyla , Salazar Ximena , Nunez Aron , Nakamura Africa , Aguayo-Romero Rodrigo , Silva-Santisteban Alfonso , Reisner Sari L. 
Published: August 2024

AbstractGlobally, transgender women (TW) face a high burden of the HIV epidemic. In Peru, HIV prevalence among TW rises at age 25, indicating a need to understand HIV vulnerability as adolescents reach adulthood. The life course of TW is often marked by abuse, discrimination and poverty fueled by transphobic stigma. Approaches to the HIV epidemic among TW and adolescents emphasize problem behaviors such as unprotected sex and substance. However, there has been a call for HIV research and interventions to understand and leverage community strengths. This qualitative study utilized a transgender-oriented, strength-based, intersectional and feminist approach to understand the strengths and protective health behaviors among 17 transgender adolescents and young women (TAYW) age 16–24 in Lima, Peru. Most participants re-located to Lima from the Amazon due to familial rejection, and engaged in obligatory sex work. TAYW demonstrated self-knowledge, motivation for education, efforts to secure employment, strong community networks, legal advocacy, avoiding problem substance use, HIV knowledge and condom use. However, strengths were impeded by multi-level barriers such as familial physical abuse, educational discrimination, and sexual assault which led to increased HIV vulnerability. We created a conceptual model of the “cycle” of HIV to describe the limits of personal responsibility within a vulnerable community denied access to family, education, employment and human rights. We recommend researchers, clinicians and public health workers follow the lead of TAYW at the frontlines of the HIV epidemic, and support beloved communities and enabling environments which may permit protective behaviors to mitigate HIV vulnerability.
Calculating Within-Pair Difference Scores in the Co-twin Control Design. Effects of Alternative Strategies
Authors: Madrid-Valero Juan J. , Verhulst Brad. , López-López José A. , Ordoñana Juan R. 
Published: August 2024

AbstractCo-twin studies are an elegant and powerful design that allows controlling for the effect of confounding variables, including genetic and a range of environmental factors. There are several approaches to carry out this design. One of the methods commonly used, when contrasting continuous variables, is to calculate difference scores between members of a twin pair on two associated variables, in order to analyse the covariation of such differences. However, information regarding whether and how the different ways of estimating within-pair difference scores may impact the results is scant. This study aimed to compare the results obtained by different methods of data transformation when performing a co-twin study and test how the magnitude of the association changes using each of those approaches. Data was simulated using a direction of causation model and by fixing the effect size of causal path to low, medium, and high values. Within-pair difference scores were calculated as relative scores for diverse within-pair ordering conditions or absolute scores. Pearson’s correlations using relative difference scores vary across the established scenarios (how twins were ordered within pairs) and these discrepancies become larger as the within-twin correlation increases. Absolute difference scores tended to produce the lowest correlation in every condition. Our results show that both using absolute difference scores or ordering twins within pairs, may produce an artificial decrease in the magnitude of the studied association, obscuring the ability to detect patterns compatible with causation, which could lead to discrepancies across studies and erroneous conclusions.
Cytokine levels in breast cancer are highly dependent on cytomegalovirus (CMV) status
Authors: Spencer Juliet V. , Liu Jianfang , Deyarmin Brenda , Hu Hai , Shriver Craig D. , Somiari Stella 
Published: August 2024

Abstract
Purpose
Breast cancer accounts for 30% of all female cancers in the US. Cytomegalovirus (CMV), a herpesvirus that establishes lifelong infection, may play a role in breast cancer. CMV is not oncogenic, yet viral DNA and proteins have been detected in breast tumors, indicating possible contribution to tumor development. CMV encodes cmvIL-10, a homolog of human cellular IL-10 (cIL-10) with potent immunosuppressive activities. We investigated the relationship between CMV infection, cytokines, and breast cancer.

Methods
We evaluated CMV serostatus and cytokine levels in plasma of women with benign breast disease (n = 38), in situ carcinoma (n = 41), invasive carcinoma, no lymph node involvement (Inv/LN−; n = 41), and invasive with lymph node involvement (Inv/LN+; n = 37).

Results
Fifty percent of the patient samples (n = 79) were CMV seropositive. There was no correlation between CMV status and diagnosis (p = 0.75). For CMV+ patients, there was a trend toward higher CMV IgG levels in invasive disease (p = 0.172). CmvIL-10 levels were higher in CMV+ in situ patients compared to the Inv/LN− and Inv/LN+ groups (p = 0.020). Similarly, cIL-10 levels were higher in CMV+ in situ patients compared to the Inv/LN− and Inv/LN+ groups (p = 0.043). The results were quite different in CMV− patients where cIL-10 levels were highest in Inv/LN− compared to benign, in situ, or Inv/LN+ (p = 0.019). African American patients were significantly associated with CMV+ status (p = 0.001) and had lower cmvIL-10 levels than Caucasian patients (p = 0.046).

Conclusion
No association was observed between CMV IgG and diagnosis, but CMV infection influences cytokine production and contributes to altered cytokine profiles in breast cancer.
An algebraic approach to circulant column parity mixers
Authors: Subroto Robert Christian 
Published: August 2024

AbstractCirculant Column Parity Mixers (CCPMs) are a particular type of linear maps, used as the mixing layer in permutation-based cryptographic primitives like Keccak-f (SHA3) and Xoodoo. Although being successfully applied, not much is known regarding their algebraic properties. They are limited to invertibility of CCPMs, and that the set of invertible CCPMs forms a group. A possible explanation is due to the complexity of describing CCPMs in terms of linear algebra. In this paper, we introduce a new approach to studying CCPMs using module theory from commutative algebra. We show that many interesting algebraic properties can be deduced using this approach, and that known results regarding CCPMs resurface as trivial consequences of module theoretic concepts. We also show how this approach can be used to study the linear layer of Xoodoo, and other linear maps with a similar structure which we call DCD-compositions. Using this approach, we prove that every DCD-composition where the underlying vector space with the same dimension as that of Xoodoo has a low order. This provides a solid mathematical explanation for the low order of the linear layer of Xoodoo, which equals 32. We design a DCD-composition using this module-theoretic approach, but with a higher order using a different dimension.
Targeting multiple receptor tyrosine kinases with sitravatinib: A Phase 1b study in advanced renal cell carcinoma and castrate-resistant prostate cancer
Authors: Pant Shubham , Cho Byoung Chul , Kyriakopoulos Christos E. , Spira Alexander , Tannir Nizar , Werner Theresa L. , Yan Xiaohong , Neuteboom Saskia , Chao Richard , Goel Sanjay 
Published: August 2024

SummarySitravatinib (MGCD516) is an oral inhibitor of several closely related oncogenic tyrosine kinase receptors that include VEGFR-2 (vascular endothelial growth factor receptor-2), AXL, and MET (mesenchymal-epithelial transition). The safety and antitumor activity of sitravatinib are reported in patients from two histologic cohorts (anti-angiogenesis-refractory clear cell renal cell carcinoma [RCC] and castrate-resistant prostate cancer [CRPC] with bone metastases) who participated in a Phase 1/1b study. The patients were enrolled using a 3-stage design that was based on observed objective responses. Objective response rate (ORR) was the primary endpoint. Duration of response, progression-free survival (PFS), overall survival (OS), and safety were also assessed. Overall, 48 patients (RCC n = 38, CRPC n = 10) received ≥ 1 dose of sitravatinib. Both cohorts were heavily pretreated (median number of prior systemic therapies: RCC cohort 3, CRPC cohort 6). In the RCC cohort, ORR was 25.9%, P = 0.015 (null hypothesis [ORR ≤ 10%] was rejected). Responses were durable (median duration 13.2 months). Median PFS was 9.5 months and median OS was 30.0 months. No objective responses were seen in the CRPC cohort; median PFS and OS were 5.8 months and 10.1 months, respectively. Across both cohorts, diarrhea (72.9%), fatigue (54.2%), and hypertension (52.1%) were the most frequent all-cause treatment-emergent adverse events (TEAEs). Diarrhea and vomiting (both, 6.3%) were the most frequent serious TEAEs considered related to study treatment. Sitravatinib demonstrated an acceptable safety profile and promising clinical activity in patients with clear cell RCC refractory to prior angiogenesis inhibitor therapy. Strong indicators for clinical activity were not seen in patients with CRPC and bone metastases. Clinical trial registration:ClinicalTrials.gov NCT02219711.
Design-Based Digital Story Program: Enhancing Coding and Computational Thinking Skills in Early Childhood Education
Authors: Metin Şermin , Kalyenci Damla , Başaran Mehmet , Relkin Emily , Bilir Büşra 
Published: August 2024

AbstractThe domain of early childhood education has witnessed an increasing emphasis on developing coding and computational thinking (CT) abilities. Scholarly investigations have delved into appropriate approaches for enhancing these proficiencies within early childhood classrooms. The present study aims to investigate the impact of a digital story design program, or Design-Based Digital Story Program (DBDS), on the coding and CT skills of 5-year-old children. Specifically designed for children aged 3–6, the DBDS program aligns with constructivism principles, which promote experiential learning. Employing a case–control quasi-experimental design, the study employed pre-intervention and post-intervention assessments and a follow-up retest after one month. The intervention involved implementing the digital story design program over 11 weeks, with three sessions per week, each lasting between 60 to 90 min, targeting five-year-old participants. The findings reveal that the DBDS program significantly enhances CT and coding skills compared to a control group. Moreover, female participants exhibited more significant improvements in CT skills post-intervention than their male counterparts, while no significant gender-based effects were observed in coding skills. These findings suggest that the DBDS program effectively supports the cultivation of coding and CT abilities among young children, warranting further exploration in diverse educational settings and across various grade levels.
Extended ProMap datasets for product mapping
Authors: Macková Kateřina , Pilát Martin 
Published: August 2024

AbstractProduct mapping or product matching is the field of research dedicated to solving the problem of identifying which product listings (including names, descriptions, specifications, images, and other information) from different e-shops refer to the same product. The problem belongs among important data integration tasks processing data originating from different sources and with different structures. In our previous work, we created basic ProMapEn and ProMapCz datasets for product mapping in English and Czech. The main advantage of the ProMap datasets compared to existing product mapping datasets is that they contain different types of non-matches based on the similarity of the two products. In this paper, we extend the previous two datasets into a completely new collection of datasets for generalized product mapping in the Czech and English languages. We publish those datasets freely for other researchers in the area of product mapping on e-commerce. The main contributions are the extension of the ProMap datasets by adding a new class of non-matching products, the introduction of new ProMapMulti datasets of product pairs from multiple English e-shops, and the introduction of ProMapTransl datasets, obtained by translating the Czech datasets to English and vice versa. Moreover, we provide a very detailed analysis of these datasets with several experiments based on neural network techniques comparing different text preprocessing methods, and similarity computation methods. We also compare the differences among several product categories and evaluate state-of-the-art product mapping methods on these datasets. We also include generalised entity matching techniques and compare their behaviour on product mapping datasets which belong to this area. Finally, we include an appendix with a number of other basic experiments, such as an analysis of feature importances.
Anti-foundationalist Coherentism as an Ontology for Relational Quantum Mechanics
Authors: Jaura Emma 
Published: August 2024

AbstractThere have been a number of recent attempts to identify the best metaphysical framework for capturing Rovelli’s Relational Quantum Mechanics (RQM). All such accounts commit to some form of fundamentalia, whether they be traditional objects, physical relations, events or ‘flashes’, or the cosmos as a fundamental whole. However, Rovelli’s own recommendation is that ‘a natural philosophical home for RQM is an anti-foundationalist perspective' (Rovelli in Philos Trans R Soc 376:10, 2018). This gives us some prima facie reason to explore options beyond these foundationalist frameworks, and take seriously a picture that lacks fundamentalia. I construct an argument from elimination in favour of an anti-foundationalist interpretation of RQM. The argument notes that priority monism and priority pluralism are exhaustive foundationalist options, and then shows that there are reasons to reject their union with RQM. I finish by recommending metaphysical coherentism as a promising anti-foundationalist alternative, which captures the key characteristics of RQM through accepting symmetrical dependence, whilst avoiding challenges by jettisoning any commitment to fundamental entities.
Examining the Link Between Social Affect and Visual Exploration of Cute Stimuli in Autistic Children
Authors: Zaharia Alexandra , Kojovic Nada , Rojanawisut Tara , Sander David , Schaer Marie , Samson Andrea C. 
Published: August 2024

AbstractBaby schema refers to physical features perceived as cute, known to trigger attention, induce positive emotions, and prompt social interactions. Given the reduced visual attention to social stimuli observed in individuals on the autism spectrum, the current study examines whether the sensitivity to baby schema is also affected. We expected that the looking time towards cute-featured stimuli would vary with symptom severity levels and would be associated with social affect. Ninety-four children (31 typically developing; 63 diagnosed with autism spectrum disorder - ASD) aged 20–83 months (M = 49.63, SD = 13.59) completed an eye-tracking visual exploration task. Autistic participants were separated into two groups based on symptom severity: children with high autism severity symptoms (HS ASD; N = 23) and low-moderate autism symptoms (LMS ASD; N = 40). Animals and neutral objects were simultaneously presented on the screen along with either human babies (condition 1) or adults (condition 2). The results indicated that visual attention oriented to cute-featured stimuli varied with autism symptom severity: only LMS and TD groups spend more time looking at cute-featured stimuli (babies; animals) than neutral objects. Moreover, children with higher severity in the social affect domain spent less time on the stimuli depicting cute than non-cute stimuli. These findings suggest that autism symptom severity and social skills are linked to variations in visual attention to cute stimuli. Implications of baby schema sensitivity are discussed in relation to the development of social competencies and play, responsiveness to robot-based interventions, as well as appraised relevance in autistic children.
Thin-walled aluminium waste remelting in circulation circuit with magnetodynamic pump
Authors: Smirnov Oleksiy , Fikssen Vladyslav , Kukhar Volodymyr , Goryuk Maksym , Hrushko Oleksandr , Rud Oleksandr , Lomakin Viktor 
Published: August 2024

AbstractModern technologies for remelting thin-walled aluminium waste are considered, and a new method to implement such process is proposed. This made it possible to increase the yield of a suitable remelted product to 83% from the mass of the initial remelting portion. The main idea is to use indirect heating of the charge. This will allow to significantly reduce the irreversible loss of metal due to burning which can reach 60%. In the proposed process, solid waste is melted by overheated melt stream. The movement of such stream is provided by the action of electromagnetic field. For the practical implementation of the offered idea, there was used a magnetodynamic pump (MDP) designed in the Physico-Technological Institute of Metals and Alloys of National Academy of Sciences of Ukraine. The MDP has a significantly higher heat and power factor than electromagnetic pumps of travelling magnetic field which are often used in similar technologies. Mathematical model of the remelting process of aluminium thin-walled and fine charge due to convective heat transfer was developed. On the basis of this model, an engineering calculation of the specific process of remelting used aluminium cans in the liquid aluminium stream was also carried out. The obtained results were used at further conducting a full-scale experiment. There is designed and successfully practically tested the experimental two-chamber circulation circuit with MDP for remelting thin-walled aluminium waste. Recommendations for further development of the proposed process were formulated.
Graphical abstract
Towards cost-effective side-chain isotope labelling of proteins expressed in human cells
Authors: Rosati Martina , Barbieri Letizia , Hlavac Matus , Kratzwald Sarah , Lichtenecker Roman J. , Konrat Robert , Luchinat Enrico , Banci Lucia 
Published: August 2024

AbstractSide chain isotope labelling is a powerful tool to study protein structure and interactions by NMR spectroscopy. 1H,13C labelling of side-chain methyl groups in a deuterated background allows studying large molecules, while side-chain aromatic groups are highly sensitive to the interaction with ligands, drugs, and other proteins. In E. coli, side chain labelling is performed by substituting amino acids with isotope-labelled precursors. However, proteins that can only be produced in mammalian cells require expensive isotope-labelled amino acids. Here we provide a simple and cost-effective method to label side chains in mammalian cells, which exploits the reversible reaction catalyzed by endogenous transaminases to convert isotope-labelled α-ketoacid precursors. We show by in-cell and in-lysate NMR spectroscopy that replacing an amino acid in the medium with its cognate precursor is sufficient to achieve selective labelling without scrambling, and how this approach allows monitoring conformational changes such as those arising from ligand binding.