bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reforma Constitucional de Jujuy (2023) y Derecho a la Consulta Libre, Previa e Informada
Authors: Leguizamón Salvatierra María Belén , Fernandez Almeida Victoria 
Published: August 2024

El presente artículo tiene como objetivo indagar en torno a la implementación del derecho a la consulta libre, previa e informada durante el proceso de reforma constitucional parcial de la provincia de Jujuy que se llevó a cabo durante septiembre del 2022 y junio de 2023.
El análisis lo realizaremos teniendo en cuenta el desarrollo del contenido y alcance del derecho a la consulta libre, previa e informada de pueblos indígenas, que se encuentra en los instrumentos de derechos humanos, que tienen jerarquía constitucional, y que a la vez fue interpretado y desarrollado por diferentes órganos de los tratados, tanto en el sistema interamericano de derechos humanos (SIDH) como en el sistema universal de derechos humanos (SUDH).
Para esto identificamos y presentamos tres instancias de análisis dentro del proceso de reforma constitucional de Jujuy: una primera etapa durante la sanción de la ley de necesidad de reforma; la segunda etapa la elección de Convencionales Constituyentes y, la tercera etapa la discusión en comisiones, que coinciden con el proceso constitucional previsto en la Constitución de 1986.
Recurrimos a información recolectada de los medios periodísticos provinciales como nacionales, la documentación presentada en procesos judiciales iniciados en el marco de la reforma y reportes de campo de observaciones realizadas durante el proceso.
Molecular analysis of 31 cases with fetal skeletal dysplasia
Authors: Taşdemir Ümit , Eyisoy Ömer Gökhan , Gezer Murad , Karaman Ali , Demirci Oya 
Published: August 2024

Abstract

Objectives
The aim of this study was to describe the prenatal ultrasound findings of fetuses with skeletal dysplasia and to evaluate the genetic variations by molecular genetic analysis.

Methods
Between August 1, 2018 and March 1, 2023, we conducted a retrospective case series at a tertiary referral center involving patients with fetal skeletal abnormalities. For cases referred for a possible diagnosis of fetal skeletal dysplasia, an ultrasound database and prenatal genetic counseling records were first searched. Terminated cases diagnosed with skeletal dysplasia by pathologic and radiologic findings and cases with skeletal dysplasia proven by postnatal clinical findings were included in the study.

Results
Between 2018 and 2023, a total of 64 cases were diagnosed as skeletal dysplasia based on radiologic findings, pathologic findings, and clinical features. The median week of the first ultrasound performed on patients is 19 0/7 weeks, while the median week of the ultrasound in which skeletal dysplasia is suspected is 21 3/7 weeks. Although micromelia was evaluated as a common feature in all cases, the most common concomitant anomaly was thoracic hypoplasia. Exome sequencing analysis was achieved in 31 (48 %) of cases. In 31 cases, in total of 35 pathogenic single gene mutations and 5 VUS (variants of uncertain significance) variants composing of 23 autosomal dominant, 10 autosomal recessive and 2 X linked recessive mutations were determined.

Conclusions
Prenatal ultrasound findings can lead us to specific diagnoses, and with the appropriate molecular analysis method, a definitive diagnosis can be made without wasting time and money.
Ability of an obstetric hemorrhage risk assessment tool to predict quantitative peripartum blood loss
Authors: Gutierrez-Disla Rubinnis , Fogel Joshua , Jacobs Allan J. 
Published: August 2024

Abstract

Objectives
Hemorrhage risk assessment tools have been studied using estimated blood loss. We study the association between peripartum hemorrhage risk assessment score and peripartum quantified blood loss (QBL) in term vaginal and cesarean deliveries.

Methods
This is a retrospective analysis conducted on 3,657 patients who underwent term vaginal and cesarean deliveries at a public hospital in New York City. Utilizing the risk assessment tool developed by the Association of Women’s Health, Obstetric and Neonatal Nurses (AWHONN), patients were categorized into low-, medium-, or high-risk groups for postpartum hemorrhage.

Results
Medium-risk (B=0.08, SE=0.01, p<0.001) and high-risk (B=0.12, SE=0.02, p<0.001) AWHONN scores were associated with significantly higher QBL as compared to low-risk AWHONN score. Medium-risk approached significance (OR: 1.67, 95 % CI: 1.00, 2.79, p=0.050) and high-risk AWHONN score was significantly associated (OR: 1.95, 95 % CI: 1.09, 3.48, p=0.02) with increased odds for postpartum hemorrhage (≥1,000 mL). Each individual factor comprising the AWHONN score whose percentage in our sample was seen in greater than 2.7 % of patients was independently significantly associated with increased QBL (six of nine factors) and postpartum hemorrhage (four of nine factors).

Conclusions
The AWHONN measure previously validated with estimated blood loss predicted obstetric blood loss with QBL. Although not on the basis of the data shown in our study, we believe that QBL should be routinely used to measure obstetric blood loss.
Crystal structure of 1-(5-(benzo[d][1,3]dioxol-5-yl)-4-benzyl-1-(4-bromophenyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)ethan-1-one, C24H20BrN3O3
Authors: Al Maqbali Anwaar S. , Al Rasbi Nawal K. , Abdel-Jalil Raid J. 
Published: August 2024

Abstract
C24H20BrN3O3, triclinic, P

1
‾

$\overline{1}$

(no. 2), a = 10.830(2) Å, b = 11.030(2) Å, c = 11.680(2) Å, α = 97.20(3)°, β = 116.70(3)°, γ = 112.50(3)°, V = 1,074.3(5) Å3, Z = 2, Rgt
(F) = 0.0809, wRref
(F
2) = 0.1895, T = 298(2) K.
A generalization of the Graham-Pollak tree theorem to even-order Steiner distance
Authors: Cooper Joshua , Tauscheck Gabrielle 
Published: August 2024

Abstract
Graham and Pollak showed in 1971 that the determinant of a tree’s distance matrix depends only on its number of vertices, and, in particular, it is always nonzero. The Steiner distance of a collection of

k

k

vertices in a graph is the fewest number of edges in any connected subgraph containing those vertices; for

k
=
2

k=2

, this reduces to the ordinary definition of graphical distance. Here we show that the hyperdeterminant of the

k

k

th order Steiner distance hypermatrix is always nonzero if

k

k

is even, extending their result beyond

k
=
2

k=2

. Previously, the authors showed that the

k

k

-Steiner distance hyperdeterminant is always zero for

k

k

odd, so together this provides a generalization to all

k

k

. We conjecture that not just the vanishing, but the value itself, of the

k

k

-Steiner distance hyperdeterminant of an

n

n

-vertex tree depends only on

k

k

and

n

n

.
Gynura procumbens Adventitious Root Ameliorates Oxidative Stress and has Cytotoxic Activity Against Cancer
Authors: Zubaidah Ummi , Sugiharto  , Siregar Muhammad Idrissa P. , Islamatasya Ufairanisa , Nisa Nabilatun , Wibowo Anjar Tri , Manuhara Yosephine Sri Wulan 
Published: August 2024

Abstract

Background: Lead exposure is a growing concern in recent public health because lead acts as an oxidant, causing oxidative stress. In this context, the administration of exogenous antioxidants is imperative. Our preliminary study revealed that Gynura procumbens leaf and root contain phenolics and flavonoids. The current study aims to determine the potency of G. procumbens adventitious root (ARGp) in preventing oxidative stress caused by lead exposure and the potential as an anti-cancer agent.

Methods: ARGp was induced from leaf explant, propagated inside a bioreactor, and macerated by methanol. Balb/C mice were used in an in vivo study and divided into 5 groups, as follows: P1 (distilled water); P2 (Pb 100 mg/L); P3 (ARGp-100 mg/L + Pb 100 mg/L); P4 (ARGp-200 mg/L + Pb 100 mg/L); and P5 (ARGp-300 mg/L + Pb 100 mg/L). Hematologic parameters, the level of lipid peroxidation, and GPx-4 antioxidant gene expression were subsequently recorded.

Results: Administration of ARGp significantly increased the hematocrit and mean corpuscular volume but did not significantly increase the mean corpuscular hemoglobin compared to lead exposure (P2). In contrast, ARGp significantly lowered the mean corpuscular hemoglobin concentration (MCHC) and white blood count compared to P2. ARGp significantly decreased liver and kidney lipid peroxidation but not in the serum. These findings are consistent with the ability of ARGp to enhance endogenous antioxidant gene expression, especially GPx-4. Furthermore, ARGp exhibited a cytotoxic effect on the hepatoma (Huh7it) cell line with an IC50 44.65 mg/L.

Conclusion: ARGp possesses antioxidants by restoring hematologic damage, lowering lipid peroxidation, and increasing antioxidant gene expression, as well as anti-cancer activity.
Late diagnosis of partial 3β-hydroxysteroid dehydrogenase type 2 deficiency – characterization of a new genetic variant
Authors: Øzdemir Cagla Margit , Nielsen Mette Mølby , Liimatta Jani , Voegel Clarissa D , Elzenaty Rawda Naamneh , Wasehuus Victor S , Lind-Holst Marie , Ornstrup Marie Juul , Gram Stine Bjørn , Ousager Lilian Bomme , Flück Christa E , Gravholt Claus H 
Published: August 2024

Summary
Congenital adrenal hyperplasia (CAH) is one of the most common inherited rare endocrine disorders. This case report presents two female siblings with delayed diagnosis of non-classical CAH 3β-hydroxysteroid dehydrogenase type 2 (3βHSD2D/HSD3B2) despite early hospital admission and apparent CAH manifestations such as infections, hirsutism, menstrual disturbances, and PCOS phenotype. Initially, sister 1 was misdiagnosed with PCOS and then 11-hydroxylase deficiency (CYP11B1), based on ultrasound, biochemical findings, and negative genetic testing for 21-hydroxylase deficiency (CYP21A2). Additional diagnostic workup was performed when sister 2also presented with symptoms of androgen excess. Genetic testing for CAH/steroid disorders finally revealed that both siblings were compound heterozygous for two variants in the HSD3B2 gene: a frameshift variant, c.558dup, p.(Thr187Hisfs*17) and a novel missense variant, c.65T>C, p.(Leu22Ser). A Synacthen test showed an insufficient cortisol increase. In vitro studies of the variants in a cell model revealed loss of function for the p.(Thr187Hisfs*17) and partial activity for p.(Leu22Ser) confirming non-classic CAH. Overlapping symptomatology and lack of specialized knowledge on steroid biosynthesis and associated rarest forms of CAH may explain the delayed diagnosis. However, with newer diagnostic methods comprising a less biased approach, very rare forms of non-classical CAH may no longer be overlooked in the future.

Learning points

Non-classic 3βHSD2 is likely underdiagnosed.

Late diagnosis of mild non-classic 3βHSD2 does occur and one should be aware of this diagnosis.

Early diagnosis of NCCAH may prevent many consequences such as severe hirsutism, prolonged menstrual irregularities, infertility, or even adrenal crisis with severe infections.

Comprehensive steroid profiling and genetic testing should be used earlier, especially when in doubt about a diagnosis.
Predictive Accuracy of Infant Clinical Sign Algorithms for Mortality in Young Infants Aged 0 to 59 Days: A Systematic Review
Authors: Shafiq Yasir , Fung Alastair , Driker Sophie , Rees Chris A. , Mediratta Rishi P. , Rosenberg Rebecca , Hussaini Anum S. , Adnan Jana , Wade Carrie G. , Chou Roger , Edmond Karen M. , North Krysten , Lee Anne CC 
Published: August 2024

CONTEXT
Clinical sign algorithms are a key strategy to identify young infants at risk of mortality.

OBJECTIVE
Synthesize the evidence on the accuracy of clinical sign algorithms to predict all-cause mortality in young infants 0–59 days.

DATA SOURCES
MEDLINE, Embase, CINAHL, Global Index Medicus, and Cochrane CENTRAL Registry of Trials.

STUDY SELECTION
Studies evaluating the accuracy of infant clinical sign algorithms to predict mortality.

DATA EXTRACTION
We used Cochrane methods for study screening, data extraction, and risk of bias assessment. We determined certainty of evidence using Grading of Recommendations Assessment Development and Evaluation.

RESULTS
We included 11 studies examining 26 algorithms. Three studies from non-hospital/community settings examined sign-based checklists (n = 13). Eight hospital-based studies validated regression models (n = 13), which were administered as weighted scores (n = 8), regression formulas (n = 4), and a nomogram (n = 1). One checklist from India had a sensitivity of 98% (95% CI: 88%–100%) and specificity of 94% (93%–95%) for predicting sepsis-related deaths. However, external validation in Bangladesh showed very low sensitivity of 3% (0%–10%) with specificity of 99% (99%–99%) for all-cause mortality (ages 0–9 days). For hospital-based prediction models, area under the curve (AUC) ranged from 0.76–0.93 (n = 13). The Score for Essential Neonatal Symptoms and Signs had an AUC of 0.89 (0.84–0.93) in the derivation cohort for mortality, and external validation showed an AUC of 0.83 (0.83–0.84).

LIMITATIONS
Heterogeneity of algorithms and lack of external validation limited the evidence.

CONCLUSIONS
Clinical sign algorithms may help identify at-risk young infants, particularly in hospital settings; however, overall certainty of evidence is low with limited external validation.
Antimicrobial resistance of Serratia marcescens causing blood stream infections in a large University Hospital in Bulgaria, an 8-year analysis (2016–2023)
Authors: Radeva Stephanie , Niyazi Denis , Bozhkova Milena , Stoeva Temenuga 
Published: August 2024

AbstractThe aim of this study is to evaluate the antimicrobial susceptibility of invasive isolates of Serratia marcescens, associated with blood stream infections (BSIs) in patients hospitalized in Varna University Hospital, Bulgaria, as well as to identify the genetic mechanisms responsible for 3rd generation cephalosporin and carbapenem-resistance among these isolates. A total of 45 consecutive S. marcescens isolates, obtained from blood cultures of 45 patients with BSIs, hospitalized during an 8-year period (2016–2023) were included. Species identification and antimicrobial susceptibility testing were done by Phoenix (BD, USA) and Vitek 2 (BioMerieux, France) systems and the results were interpreted according to EUCAST guidelines. The genetic mechanisms of beta-lactam resistance were studied by PCR. During the study period, a total of 45 patients were diagnosed with S. marcescens-associated BSIs. All infections were defined as nosocomial, predominantly intensive care unit-acquired (42.2%) and 28.8% were central venous catheter-associated. The following antimicrobial resistance rates were found: ceftriaxone, piperacillin/tazobactam, 57.8%; ceftazidime, 55.6%; cefepime, trimethoprime/sulfamethoxazole, 53.3%; gentamicin, 48.8%; ciprofloxacin, 44.5%; amikacin, 15.6%; carbapenems, 2.2%. The blaCTX-M was identified in 88.9% of the tested 3rd generation cephalosporin resistant isolates. Among these, 50% were also blaTEM positive. The single carbapenem-resistant isolate harboured blaKPC, blaCTX-M1/9, blaCMY-2 and blaTEM. This study demonstrates S. marcescens as a problematic nosocomial pathogen and we report a KPC-producing S. marcescens clinical isolate from a BSI in Bulgaria.
Attentional bias to social media stimuli is moderated by fear of missing out among problematic social media users
Authors: Wang Yang , Elhai Jon D. , Montag Christian , Zhang Lei , Yang Haibo 
Published: August 2024

AbstractBackground and aimsPrevious evidence has indicated that problematic social media use (PSMU) is characterized by an attentional bias to social media icons (such as Facebook icons), but not to social webpages (such as Facebook webpages). They suggest that there may be other factors influencing attentional bias like fear of missing out (FoMO). But it remains unclear how FoMO moderates attentional bias in PSMU. This study aims to investigate whether PSMU show attentional bias for stimuli associated with social media, and how FoMO moderates on attentional bias among PSMU through experimental methods.MethodsBased on the Interaction of Person-Affect-Cognition-Execution (I-PACE) model, this study explored mechanisms of attentional bias to social media icons (such as WeChat) related to PSMU and further examined the role of FoMO in this relationship. Specifically, attentional bias patterns to social media icons of 62 participants (31 PSMU and 31 control group) were explored during a dot-probe paradigm combined with eye-tracking in Experiment 1, and attentional bias patterns to social media icons of another 61 individuals with PSMU with different FoMO levels was explored during a dot-probe paradigm combined with eye-tracking in Experiment 2.ResultsResults revealed that individuals with PSMU had an attentional bias toward social media icons, demonstrated by attentional maintenance, and such bias such bias was moderated by FoMO negatively, demonstrated by attentional vigilance and maintenance in PSMU/high FoMO.ConclusionThese results suggest that attentional bias is a common mechanism associated with PSMU, and FoMO is a key factor on the development of PSMU.
Effect of air pollution on the leaf morphology and anatomy of common plant species of Kathmandu Valley
Authors: Devkota Anjana , Shrestha Sushila , Jha PK 
Published: August 2024

The present study was mainly aimed to study the effect of air pollution on the morphological and anatomical characteristics of leaf of 6 common plant species viz., Bougainvillea glabra, Callistemon citrinus, Euphorbia pulcherrima, Jasminum mesnyi, Lagerstroemia indica and Nerium oleander from different location of Kathmandu Valley. Results showed that all plant species exhibited significant (p<0.05) reduction at polluted site in their leaf length, width, and area when compared with the same plant species of non-polluted site. Results also showed that the overall reduction % in leaf length, width and area during different seasons at heavily polluted sites with respect to those of less polluted sites were found maximum during post monsoon than in pre-monsoon. Results also interpreted that maximum reduction in leaf length (25. and leaf width(18.62%) was recorded in E. pulchirrima, and leaf area (28%) was recorded in L. indica.; while minimum decrease in leaf length (7.58%) in N. oleander and width(11.3%) as well as area (13.90%) in C. citrinus. was recorded. Likewise, the highest stomatal index (20.58%) and number of epidermal cells (30.4) were recorded in Lagerstroemia indica; while highest stomatal density (134.8mm-2) and number of clogged stomata (8.33mm-2) was recorded in Bougainvillea glabra and Nerium oleander respectively.
Results further indicated that as the plants get ages, the reduction % of various leaf attributes of polluted plants also increased as compared with less polluted plant species. This could be mainly due to maximum exposure of plants to air pollutants come from various auto emission sources. This study showed that plants generally respond to air pollution with reduction
in foliar features and the response is species specific.
Sistema de orientación de un aerogenerador empleando Fuzzy Logic Controller
Authors: Díaz Barrio Roberto , Santos Peña Matilde , Armenta Déu Carlos 
Published: August 2024

A la hora de generar energía eléctrica empleando aerogeneradores para aprovechar la fuerza del viento, hay que tener en cuenta que estos han de orientarse de forma correcta respecto al mismo; ya que de no hacerlo, no serán capaces de aprovechar la energía disponible, e incluso podrán producirse cargas y efectos anómalos que pueden perjudicar el conjunto de la máquina de forma estructural. En este trabajo se pretende obtener empleando un controlador con lógica borrosa (Fuzzy Logic Controller, FLC), un sistema que mantenga la orientación correcta del aparato. Para ello, se presentará un modelo de planta adecuado, para a continuación comentar la lógica que ha de seguir el control debido a las características del modelo. Al final, se validará todo
mediante simulaciones en las que el modelo obtenido tendrá que mantener la orientación ante distintas casuísticas, y por último e comentarán las conclusiones extraídas de la realización del trabajo.
Localización de emisiones de metano combinando un sensor TDLAS y un robot móvil
Authors: Ojeda Pepe , Monroy Javier , González-Jiménez Javier 
Published: August 2024

Este trabajo aborda el problema de la localización eficiente de emisiones de metano en espacios abiertos mediante el uso de robótica móvil. En contraposición a los métodos convencionales que emplean detectores puntuales, o que empleando medidores de rango dependen del suelo como reflector natural (los cuales conllevan largos tiempos e ineficientes trayectorias de inspección), se propone un enfoque robótico que aumenta la eficiencia de la toma de datos. Para ello se monta un detector de rango sobre una unidad pan-tilt que apunta continuamente a un robot móvil que actúa como reflector artificial, permitiendo tomar medidas sobre el plano horizontal. Este enfoque permite abarcar grandes superficies en cortos espacios de tiempo sin perder resolución espacial. Los resultados obtenidos en un área experimental de 140 m2 validan la efectividad de este enfoque para la rápida detección y localización de fuentes de emisión de gas metano.
Association of Researcher Characteristics and Entrepreneurial Intention
Authors: Terán-Pérez Beatriz M , Valdez-Lafarga Cuitlahuac , Ballardo-Cárdenas Denisse , Valdez-Torres José B 
Published: August 2024

Investigating the antecedents and determinants of entrepreneurial intention is key to understanding the beginning of the entrepreneurial process. There is scarce literature on academic entrepreneurship that identifies the characteristics of an individual in an academic context with the intention of starting a spin-off company. This study explores the association of gender, age, research certification and knowledge area to Academic Entrepreneurial Intention. To this end, data was obtained from the participation of 172 academics at a Mexican university. Through logistic regression, it was possible to find a significant association between age, research certification and certain knowledge areas to academic entrepreneurial intention. This represents a first approximation to identifying the key factors that affect the academic entrepreneurship process, focused particularly on entrepreneurial intention.
JEL Codes: L26, M13
Received: 06/03/2024. Accepted: 03/06/2024. Published: 20/06/2024.