bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐Reported Quality of Life Before and After Aerobic Exercise Training in Individuals with Hypertension: A Randomised‐Controlled Trial
Authors: Maruf Fatai A. , Akinpelu Aderonke O. , Salako Babatunde L. 
Published: March 2013

BackgroundThe Effects of Aerobic Exercise Training (AET) on self‐reported Quality of Life (QoL) in people with hypertension have been previously documented. However, data on black populations, especially from Africa, seem not to be available. This study investigated the effects of AET on QoL and exercise capacity in Nigerians on treatment for essential hypertension.MethodThis randomised‐controlled trial involved newly diagnosed individuals, with mild‐to‐moderate essential hypertension randomly assigned to antihypertensive drugs (ADs) alone (control: n = 60) and AET+ADs (exercise: n = 60) groups. The study lasted for 12 weeks. QoL was measured using the World Health Organization QoL Short Form (WHOQoL‐BREF) and exercise capacity was assessed using the Rockport Fitness Walk Test pre‐ and post‐study.ResultsPhysical health, psychological health, and social relationships domains of QoL improved significantly in the exercise and control groups post‐intervention. The environment domain of QoL and exercise capacity improved significantly in only the exercise group. There were larger improvements in the physical health, psychological health, and environment domains of QoL, and exercise capacity in the exercise group.ConclusionAerobic exercise improves QoL and exercise capacity in individuals with essential hypertension.
Motility and fertility of boar semen after liquid preservation at 5°C for more than 2 weeks
Authors: Namula Zhao , Sato Yoko , Kodama Risa , Morinaga Kouta , Luu Vien Viet , Taniguchi Masayasu , Nakai Michiko , Tanihara Fuminori , Kikuchi Kazuhiro , Nagai Takashi , Otoi Takeshige 
Published: March 2013

AbstractThis study investigated the effects of skim milk on the quality and fertility of boar spermatozoa under long‐term chilled preservation. Semen samples were stored in Modena solution supplemented with 0 (control) to 50 mg/mL skim milk at 5°C for 4 weeks; spermatozoa stored with 7.5 and 15 mg/mL of skim milk (7.5‐SM and 15‐SM groups, respectively) exhibited significantly higher motility indices than those of the control group up to 3 weeks (P < 0.05), and the 7.5‐SM group showed improved motility indices even after 4 weeks (P < 0.05). In vitro fertilization using spermatozoa in the 7.5‐SM and 15‐SM groups stored at 5°C for 2 weeks showed significantly higher fertilization rates of spermatozoa and the development rates to blastocyst than the control group (P < 0.05), and the 7.5‐SM group showed similar rates of fertilization and blastocyst formation in the fresh non‐stored spermatozoa group. After artificial insemination using spermatozoa stored for 2 weeks in the 7.5‐SM group, healthy piglets were obtained. Boar spermatozoa can be stored at 5°C in a Modena solution containing skim milk. Supplementation of 7.5 mg/mL skim milk improves boar spermatozoa motility and fertility even after liquid preservation at 5°C for 2 weeks.
A novel approach to pharmaco‐EEG for investigating analgesics: assessment of spectral indices in single‐sweep evoked brain potentials
Authors: Gram Mikkel , Graversen Carina , Nielsen Anders K. , Arendt‐Nielsen Thomas , Mørch Carsten D. , Andresen Trine , Drewes Asbjørn M. 
Published: March 2013

AimsTo compare results from analysis of averaged and single‐sweep evoked brain potentials (EPs) by visual inspection and spectral analysis in order to identify an objective measure for the analgesic effect of buprenorphine and fentanyl.MethodsTwenty‐two healthy males were included in a randomized study to assess the changes in EPs after 110 sweeps of painful electrical stimulation to the median nerve following treatment with buprenorphine, fentanyl or placebo patches. Bone pressure, cutaneous heat and electrical pain ratings were assessed. EPs and pain assessments were obtained before drug administration, 24, 48, 72 and 144 h after beginning of treatment. Features from EPs were extracted by three different approaches: (i) visual inspection of amplitude and latency of the main peaks in the average EPs, (ii) spectral distribution of the average EPs and (iii) spectral distribution of the EPs from single‐sweeps.ResultsVisual inspection revealed no difference between active treatments and placebo (all P > 0.05). Spectral distribution of the averaged potentials showed a decrease in the beta (12–32 Hz) band for fentanyl (P = 0.036), which however did not correlate with pain ratings. Spectral distribution in the single‐sweep EPs revealed significant increases in the theta, alpha and beta bands for buprenorphine (all P < 0.05) as well as theta band increase for fentanyl (P = 0.05). For buprenorphine, beta band activity correlated with bone pressure and cutaneous heat pain (both P = 0.04, r = 0.90).ConclusionIn conclusion single‐sweep spectral band analysis increases the information on the response of the brain to opioids and may be used to identify the response to analgesics.
Phenomenology of bipolar disorder not otherwise specified in youth: a comparison of clinical characteristics across the spectrum of manic symptoms
Authors: Hafeman Danella , Axelson David , Demeter Christine , Findling Robert L , Fristad Mary A , Kowatch Robert A , Youngstrom Eric A , Horwitz Sarah McCue , Arnold L Eugene , Frazier Thomas W , Ryan Neal , Gill Mary Kay , Hauser‐Harrington Jessica C , Depew Judith , Rowles Brieana M , Birmaher Boris 
Published: March 2013

ObjectivesControversy surrounds the diagnostic categorization of children with episodic moods that cause impairment, but do not meet DSM‐IV criteria for bipolar I (BD‐I) or bipolar II (BD‐II) disorder. This study aimed to characterize the degree to which these children, who meet criteria for bipolar disorder not otherwise specified (BD‐NOS), are similar to those with full syndromal BD, versus those with no bipolar spectrum diagnosis (no BSD).MethodsChildren aged 6–12 years were recruited from nine outpatient clinics, preferentially selected for higher scores on a 10‐item screen for manic symptoms. Interviews with the children and their primary caregivers assessed a wide array of clinical variables, as well as family history.ResultsA total of 707 children [mean ± standard deviation (SD) 9.4 ± 1.9 years old] were evaluated at baseline, and were diagnosed with BD‐I (n = 71), BD‐II (n = 3), BD‐NOS (including cyclothymia; n = 88), or no BSD (n = 545). Compared to BD‐I, the BD‐NOS group had less severe past functional impairment. However, current symptom severity and functional impairment did not differ between BD‐NOS and BD‐I, even though both groups were significantly more symptomatic and impaired than the no BSD group. Parental psychiatric history was similar for the BD‐NOS and BD‐I groups, and both were more likely than the no BSD group to have a parent with a history of mania. Rates of elated mood did not differ between BD‐NOS and BD‐I youth.ConclusionsChildren with BD‐NOS and BD‐I are quite similar, but different from the no BSD group, on many phenomenological measures. These findings support the hypothesis that BD‐NOS is on the same spectrum as BD‐I.
Does BCR/ABL1 positive Acute Myeloid Leukaemia Exist?
Authors: Nacheva Ellie P. , Grace Colin D. , Brazma Diana , Gancheva Katya , Howard‐Reeves Julie , Rai Lena , Gale Rosemary E. , Linch David C. , Hills Robert K. , Russell Nigel , Burnett Alan K. , Kottaridis Panagiotis D. 
Published: March 2013

SummaryThe BCR/ABL1 fusion gene, usually carried by the Philadelphia chromosome (Ph) resulting from t(9;22)(q34;q11) or variants, is pathognomonic for chronic myeloid leukaemia (CML). It is also occasionally found in acute lymphoblastic leukaemia (ALL) mostly in adults and rarely in de novo acute myeloid leukaemia (AML). Array Comparative Genomic Hybridization (aCGH) was used to study six Ph(+)AML, three bi‐lineage and four Ph(+)ALL searching for specific genomic profiles. Surprisingly, loss of the IKZF1 and/or CDKN2A genes, the hallmark of Ph(+)ALL, were recurrent findings in Ph(+)AML and accompanied cryptic deletions within the immunoglobulin and T cell receptor genes. The latter two losses have been shown to be part of ‘hot spot’ genome imbalances associated with BCR/ABL1 positive pre‐B lymphoid phenotype in CML and Ph(+)ALL. We applied Significance Analysis of Microarrays (SAM) to data from the ‘hot spot’ regions to the Ph(+)AML and a further 40 BCR/ABL1(+) samples looking for differentiating features. After exclusion of the most dominant markers, SAM identified aberrations unique to de novo Ph(+)AML that involved relevant genes. While the biological and clinical significance of this specific genome signature remains to be uncovered, the unique loss within the immunoglobulin genes provides a simple test to enable the differentiation of clinically similar de novo Ph(+) AML and myeloid blast crisis of CML.
Clinicopathological prognostic indicators in 107 patients with diffuse large B‐cell lymphoma transformed from follicular lymphoma
Authors: Maeshima Akiko M. , Taniguchi Hirokazu , Fukuhara Suguru , Maruyama Dai , Kim Sung‐Won , Watanabe Takashi , Kobayashi Yukio , Tobinai Kensei , Tsuda Hitoshi 
Published: March 2013

Follicular lymphoma (FL) frequently transforms into diffuse large B‐cell lymphoma (DLBCL). To clarify the associated clinicopathological prognostic parameters, we examined the correlation of 11 histopathological parameters with progression‐free survival (PFS) and overall survival (OS) in 107 consecutive patients who had DLBCL with pre‐existing (asynchronous) or synchronous FL. The patients comprised 58 men and 49 women with a median age of 56 years. For DLBCL, the complete response rate was 81%, overall response rate was 88%, and 5‐year PFS and OS rates were 55% and 79%, respectively. Immunohistochemical analysis of the DLBCL component revealed the following positivity rates: CD10, 64%; Bcl‐2, 83%; Bcl‐6, 88%; MUM1, 42%; GCB, 82%; cMyc index ≥80%, 17%; and Ki‐67 index ≥90%, 19%. IGH/BCL2 fusion was positive in 57% of DLBCL cases. In univariate analyses, asynchronous FL and DLBCL (24%, P = 0.021), 100% proportion of DLBCL (29%, P = 0.004), Bcl‐2 positivity (P = 0.04), and high Ki‐67 index (P = 0.003) were significantly correlated with shorter PFS. Asynchronous FL and DLBCL (P = 0.003), 100% proportion of DLBCL (P = 0.001), and high Ki‐67 index (P = 0.004) were significantly correlated with shorter OS. In a multivariate analysis, asynchronous FL and DLBCL (P = 0.035) and 100% proportion of DLBCL (P = 0.016) were significantly correlated with shorter OS. Thus, asynchronism and 100% proportion of DLBCL, that is, FL relapsed as pure DLBCL, or FL and DLBCL at different sites, were significant predictors of unfavorable outcome of patients with DLBCL transformed from FL.
Development and Applications of Porous Tantalum Trabecular Metal‐Enhanced Titanium Dental Implants
Authors: Bencharit Sompop , Byrd Warren C. , Altarawneh Sandra , Hosseini Bashir , Leong Austin , Reside Glenn , Morelli Thiago , Offenbacher Steven 
Published: March 2013

AbstractBackgroundPorous tantalum trabecular metal has recently been incorporated in titanium dental implants as a new form of implant surface enhancement. However, there is little information on the applications of this material in implant dentistry.PurposeThe purpose of this article is to summarize the contemporary concept on the applications of porous tantalum trabecular metal in implant dentistry.Materials and MethodsWe therefore review the current literature on the basic science and clinical uses of this material.ResultsPorous tantalum metal is used to improve the contact between osseous structure and dental implants and therefore presumably facilitate osseointegration. Success of porous tantalum metal in orthopedic implants led to the incorporation of porous tantalum metal in the design of root‐form endosseous titanium implants. The porous tantalum three‐dimensional enhancement of titanium dental implant surface allows for combining bone ongrowth together with bone ingrowth, or osseoincorporation. While little is known about the biological aspect of the porous tantalum in the oral cavity, there seems to be several possible advantages of this implant design. This article reviews the biological aspects of porous tantalum‐enhanced titanium dental implants, in particular the effects of anatomical consideration and oral environment to implant designs.ConclusionsWe propose here possible clinical situations and applications for this type of dental implant. Advantages and disadvantages of the implants as well as needed future clinical studies are discussed.
Retentive Strength of Two‐Piece CAD/CAM Zirconia Implant Abutments
Authors: Gehrke Peter , Alius Jochen , Fischer Carsten , Erdelt Kurt J. , Beuer Florian 
Published: March 2013

AbstractPurposeThe purpose of this study is to evaluate the retention of two‐piece computer‐aided design (CAD)/computer aided manufacturing (CAM) zirconia abutments after artificial aging under simulated oral conditions using three different types of resin‐based luting agents.Material and MethodsTwenty‐one CAD/CAM‐generated zirconia copings (CERCON Compartis, Degudent, Hanau, Germany) were bonded to a prefabricated secondary titanium implant insert (XiVE Ti‐Base, Dentsply Friadent, Mannheim, Germany), using three different types of resin‐based luting agents: group A: Panavia 21 (Kuraray Co, Kurashiki, Japan); group B: Multilink Implant (Ivoclar Vivadent, Schaan, Liechtenstein); and group C: SmartCem2 (Dentsply DeTrey, Konstanz, Germany). The bonding surfaces of the titanium inserts and the zirconia ceramic copings were air‐abraded and cleaned in alcohol. All specimens were stored in distilled water for 60 days and subsequently thermal‐cycled 15,000 times (5–55°C). The dislodging force of the copings along the long axis of the implant/abutment complex was recorded using a universal testing machine with 2 mm/min crosshead speed. Data were analyzed descriptively and by performing the Kruskal–Wallis test.ResultsThe mean retention values were 924.93 ± 363.31 N for Panavia 21, 878.05 ± 208.33 N for Multilink Implant, and 650.77 ± 174.92 N for SmartCem2. The Kruskal–Wallis test indicated no significant difference between the retention values of the tested luting agents (p = 0.1314). The failure modes of all tested two‐piece abutments were completely adhesive, leaving the detached zirconia coping and titanium insert undamaged.ConclusionThe use of resin‐based luting agents in combination with air abrasion of titanium inserts and zirconia copings led to a stable retention of two‐piece CAD/CAM abutments. The bonding stability of the investigated luting agents exceeded the general limits of fracture resistance of two‐piece zirconia abutments. A notable difference between the mean retention values of the tested bond materials was shown. However, the statistical analysis revealed that this difference was not significant.
Early Loading of Implants with Fixed Dental Prostheses in Edentulous Mandibles: 7.2‐Year Clinical Results from a Prospective Study
Authors: Schwarz Stefanie , Bernhart Gunda , Eiffler Constantin , Hassel Alexander Jochen , Lehmann Franziska , Rammelsberg Peter 
Published: March 2013

AbstractPurposeThe purpose of this prospective follow‐up study was to evaluate survival and success of early‐loaded implants placed in the edentulous mandible and the survival of the fixed dental prostheses (FDPs) after in mean 7.2 years.Materials and MethodsThirty‐seven patients (mean age 64.5 years, 18.9% male) received 185 implants in the intraforaminal area of the edentulous mandible (five implants per patient). Within 2 weeks, all implants were early loaded with fixed dental prostheses. The patients were recalled once a year for clinical and radiographic examinations. The 17 patients (79 implants) attending the recall in 2012 were additionally asked for their satisfaction of functional and aesthetic aspects.ResultsDuring a mean observation time of 7.2 years, 20 implants were lost in 11 patients, resulting in implant survival of 89.2%. Eight of all implants (4.3%) had too much marginal bone loss to satisfy the criteria of success. A total of 19 prosthetic complications and aftercare measurements had to be performed between in mean 4.5 to 7.2 years of observation. The survival of the originalFDPsdecreased to 83.8%. Of the 17 patients attending the recall in 2012, a total 59.5% had a satisfactory oral hygiene. According to the criteria ofAlbrektsson, the success rate for the remaining 79 implants was 89.9% after in mean 11.7 years. Patient satisfaction for assessment of functional and aesthetic aspects was in median 9 and 8 on the numeric rating scales.ConclusionLong‐term observation of in mean 7.2 years showed satisfactory results for both implant and superstructure survival. Prosthetic complications were easy to repair in most cases, but patients' ability for oral hygiene was reduced after the longer observation period. Especially in elderly patients, their attitudes and manual skills should be considered when planning the design of a new superstructure.
Glutathione Prevents Free Fatty Acids‐Induced Oxidative Stress and Apoptosis in Human Brain Vascular Endothelial Cells Through Akt Pathway
Authors: Zhou Hou‐Guang , Liu Ling , Zhang Yu , Huang Yan‐Yan , Tao Ying‐Hong , Zhang Shuo , Su Jing‐Jing , Tang Yu‐Ping , Guo Zhuang‐Li , Hu Ren‐Ming , Dong Qiang 
Published: March 2013

SummaryAimsThe damage of human brain vascular endothelial cells (HBVECs) is the key pathogenesis of diabetes‐associated cerebral vascular complications. The aim of this study was to elucidate the effects of glutathione (GSH) on free fatty acids (FFAs)‐induced HBVECs apoptosis, oxidative stress, and the involved possible signaling pathway.MethodsAfter culturing HBVECs for 72 h with GSH and FFAs, we determined cell proliferation by CCK8, detected apoptosis by caspase‐3 and Annexin V‐FITC/PI staining, and judged oxygen stress by determining the reactive oxygen species (ROS) and the mitochondrial membrane potential (MMP). We investigated whether the Akt pathway was involved in FFAs‐induced signaling pathway alteration and whether GSH influenced the above effects.ResultsAfter being cultured in 200 μM FFAs for 72 h, the HBVECs proliferation significantly decreased; HBVECs apoptosis increased; the ROS levels increased; and the HBVECs MMP subsequently decreased. FFAs induced a significant decrease in phosphorylated active Akt. These alterations were obviously prevented when 1 mM GSH was added to culture medium containing FFAs, and the above effects of GSH were blocked by Akt inhibitor.ConclusionGSH may prevent FFAs‐induced HBVECs damage, oxidative stress, and apoptosis through activating the Akt pathway.
Influence of enhanced recovery after surgery pathways and laparoscopic surgery on health‐related quality of life
Authors: Khan S. A. , Ullah S. , Ahmed J. , Wilson T. R. , McNaught C. , Hartley J. , MacFie J. 
Published: March 2013

AbstractAimThis study set out to compare the postoperative health related quality of life (HQoL) of patients undergoing elective open colorectal surgery using a well‐established enhanced recovery after surgery (ERAS) pathway with those undergoing laparoscopic surgery without an established an ERAS pathway.MethodUsing a power calculation, it was estimated that 40 patients would be required in each group. HQoL of the two groups was prospectively assessed using SF‐12 (Short Form 12) and EORTC QLQ 30 (European Organisation of Research and Treatment of Cancer, Quality of Life Questionnaire) preoperatively, and at 2 and 6 weeks after discharge.ResultsData were collected from 83 patients, 41 in the laparoscopic group and 42 in the open–ERAS group. There was a significant difference between the median length of stay of the open–ERAS (5 days) and laparoscopic (7 days, P = 0.028) groups. There were no significant differences between the HQoL score of the two groups at any stage. In both groups, the majority of HQoL scores had improved considerably by 6 weeks.ConclusionLaparoscopic and open–ERAS surgery have a similar impact on postoperative HQoL. HQoL tends to improve by the 6‐week stage.
Is hybrid robotic laparoscopic assistance the ideal approach for restorative rectal cancer dissection?
Authors: Zawadzki M. , Velchuru V. R. , Albalawi S. A. , Park J. J. , Marecik S. , Prasad L. M. 
Published: March 2013

AbstractAimWhile the use of robotic assistance in the management of rectal cancer has gradually increased in popularity over the years, the optimal technique is still under debate. The authors' preferred technique is a robotic low anterior resection that requires a hybrid approach with laparoscopic hand‐assisted mobilization of the left colon and robotic assistance for rectal dissection. The aim of this study was to determine the efficacy of this approach as it relates to intra‐operative and short‐term outcomes.MethodBetween August 2005 and July 2011, consecutive patients undergoing rectal dissection for cancer via the hybrid robotic technique were included in our study. Demographics, margin positivity, intra‐operative and short‐term outcomes were evaluated.ResultsThe preferred approach was performed in 77 patients with rectal adenocarcinoma. Of these, 68 underwent low anterior resection and nine had a coloanal pull‐through procedure (mean age 60.1 years; mean body mass index 28.0 kg/m2; mean operative time 327 min; conversion rate 3.9%). Three patients (3.9%) had positive resection margins (one circumferential, two distal). Five patients had an anastomotic leak (6.4%). No robot‐specific complications were observed.ConclusionThe hybrid approach involving hand‐assisted left colon mobilization and robotic rectal dissection is a safe and feasible technique for minimally invasive low anterior resection. This approach can be considered an viable option for surgeons new to robotic rectal dissection.
Clinicopathological features of colorectal polyps: evaluation of the ‘predict, resect and discard’ strategies
Authors: Sakamoto T. , Matsuda T. , Nakajima T. , Saito Y. 
Published: March 2013

AbstractAim‘Predict, resect and discard’ strategies for diminutive and small colonic polyps are considered to be cost effective for treating colorectal cancers. The aim of this study was to determine, retrospectively, the histological features of colonic polyps resected by endoscopic procedures or surgery using an updated database.MethodWe retrospectively analysed the clinicopathological features of colorectal polyps, less than 20 mm in size, which were removed by endoscopy from January 2009 to November 2011 at the National Cancer Center Hospital (NCCH) in Tokyo, Japan.ResultsLess than 1% of diminutive polyps (≤ 5 mm) were classified as mucosal high‐grade neoplasia (Category 4), and no submucosal invasion by carcinoma (Category 5) lesions were noted. However, 3% of small polyps (6–9 mm) were classified as Category 5; of these, 6% were submucosal deep invasive cancers. Morphologically, depressed components were observed more frequently in carcinomas than in adenomas in both small and large polyps (10–20 mm).ConclusionIn light of the ‘predict, resect and discard’ strategies for small polyps, we should pay attention to the possible clinical malignancy of small and large polyps. We recommend that these strategies should be applied selectively and that they should be informed by accurate endoscopic evaluations.