bluuebunny/crossref_metadata_2025_split huggingface dataset:
KETERKAITAN BONUS DEMOGRAFI DENGAN TEORI GENERASI
Authors: Lubis Bertha , Mulianingsih Sunasih 
Published: August 2024

ABSTRAK
Kajian ini bertunjuan memberikan gambaran bahwa fenomena bonus demografi yang terjadi pada rentang waktu 2010 – 2025 akan berdampak besar terhadap kondisi kehidupan manusia di planet bumi ini. Teori generasi Strauss-Howe, memberikan gambaran munculnya generasi Alfa yang akan berdampak luas terhadap kondisi kehidupan manusia pada umumnya. Dengan menggunakan kajian pustaka yang dikumpulkan dari berbagai sumber baik dalam jejaring (online) maupun di luar jejaring (offline), dilengkapi dengan wawancara dan diskusi dengan pihak terkait, diperoleh gambaran yang lebih memadai. Hasilnya menunjukkan bahwa teori gernerasi Strauss-Howe, selama ini dipercaya menjadi acuan bagi munculnya generasi-generasi sesuai rentang waktu yang memberikan ciri-ciri tertentu, semakin hari semakin menunjukkan kemajuan dan perkembangan teknologi yang luar biasa dahsyatnya.
Kata kunci: bonus demografi, dampak, strauss-howe, teori generasi.

ABSTRACT
This study shows that the demographic bonus phenomenon that occurred in the period 2010-2025 will have a major impact on the conditions of human life on this planet. Strauss-Howe's generation theory provides an overview of the emergence of the Alfa generation that will have a broad impact on the conditions of human life in general. By using literature reviews collected from various sources both online and offline, equipped with interviews and discussions with related parties, a more adequate picture is obtained. The results show that Strauss-Howe's gerneration theory, has been believed to be a reference for the emergence of generations according to the timeframe that gives certain characteristics, increasingly shows the extraordinary progress and development of technology.
Keywords: demographic bonus, generation theory, impact, strauss-howe.
PELAKSANAAN PENDAFTARAN PENDUDUK OLEH DINAS KEPENDUDUKAN DAN PENCATATAN SIPIL DI KOTA PADANG
Authors: Mulya Hadyan , Irena Devi 
Published: August 2024

ABSTRAK
Tujuan dari tulisan ini adalah mengetahui bagaimana pelaksanaan pendaftaran penduduk, faktor apa yang mempengaruhi serta upaya yang dilakukan pemerintah dalam mengatasi persoalan pendaftaran penduduk di Kota Padang. Metode kajian yang digunakan deskriptif kualitatif dengan pendekatan induktif. Pengumpulan data dan informasi dilakukan dengan cara observasi, wawancara dan dokumentasi. Untuk teknik analisis data dilakukan dengan reduksi data, penyajian data dan penarikan kesimpulan.
Kesimpulan yang didapatkan bahwasanya pelaksanaan pendaftaran penduduk oleh dinas kependudukan dan pencatatan sipil di Kota Padang belum sepenuhnya berjalan lancar. faktor yang mendukung lokasi kantor, keadaan sosial masyarakat, dan akses transportasi dan faktor yang menghambat sarana dan prasarana yang belum memadai, sumber daya manusia terbatas, kurangnya sosialisasi kepada masyarakat. Upaya yang dilakukan Dians Kependudukan dan Pencatatan Sipil Kota Padang untuk mengatasi persoalan pendaftaran penduduk ini dengan memaksimalkan sarana dan prasarana yang dimiliki, menciptakan inovasi baru, dan meningkatkan sosialisasi kepada masyarakat.
Kata Kunci: Pelaksanaan, Pendaftaran, Penduduk

ABSTRACT
The purpose of this research is to knowing how the implementation of civil population registration, the affect factor and the efforts that government do to solve the problems of civil population registration in Padang city. The method is quantitative descriptive with inductive approach. The information and data accumulation do by using observation, interview and documentation. The data analysis technic is data reduction, data presentation and conclusion. The conclusion is the implantation of civil population registration in Padang city does not good enough. The support factors are the office location, the condition of local people and transportation access. The inhibiting factors are the infrastructure and facility is not satisfy enough. limited human resources, lack of socialization to the community. Efforts made by the department of population and civil registration in the Padang city overcome the problem of population registration by maximizing the facilities and infrastructure owned, creating new innovations, and increasing socialization to the community.
Keywords: Implementation, Registration, Population
Integrated cellular 4D-TIMS lipidomics and transcriptomics for characterization of anti-inflammatory and anti-atherosclerotic phenotype of MyD88-KO macrophages
Authors: del Barrio Calvo Carla , Bindila Laura 
Published: August 2024

Introduction: Recent progress in cell isolation technologies and high-end omic technologies has allowed investigation of single cell sets across multiple omic domains and a thorough exploration of cellular function and various functional stages. While most multi-omic studies focused on dual RNA and protein analysis of single cell population, it is crucial to include lipid and metabolite profiling to comprehensively elucidate molecular mechanisms and pathways governing cell function, as well as phenotype at different functional stages.Methods: To address this gap, a cellular lipidomics and transcriptomics phenotyping approach employing simultaneous extraction of lipids, metabolites, and RNA from single cell populations combined with untargeted cellular 4 dimensional (4D)-lipidomics profiling along with RNA sequencing was developed to enable comprehensive multi-omic molecular profiling from the lowest possible number of cells. Reference cell models were utilized to determine the minimum number of cells required for this multi-omics analysis. To demonstrate the feasibility of higher resolution cellular multi-omics in early-stage identification of cellular phenotype changes in pathological and physiological conditions we implemented this approach for phenotyping of macrophages in two different activation stages: MyD88-knockout macrophages as a cellular model for atherosclerosis protection, and wild type macrophages.Results and Discussion: This multi-omic study enabled the determination of the lipid content remodeling in macrophages with anti-inflammatory and atherosclerotic protective function acquired by MyD88-KO, hence expedites the understanding of the molecular mechanisms behind immune cells effector functionality and of possible molecular targets for therapeutic intervention. An enriched functional role of phosphatidylcholine and plasmenyl/plasmalogens was shown here to accompany genetic changes underlying macrophages acquisition of anti-inflammatory function, finding that can serve as reference for macrophages reprogramming studies and for general immune and inflammation response to diseases.
Investigating cutaneous tuberculosis and nontuberculous mycobacterial infections in a Department of Dermatology, Beijing, China: a comprehensive clinicopathological analysis
Authors: Wang Xin-Yu , Jia Qian-Nan , Li Jun , Zheng He-Yi 
Published: August 2024

BackgroundCutaneous tuberculosis (CTB) and nontuberculous mycobacteria (NTM) infections present considerable diagnostic and therapeutic challenges. This study aims to provide a comprehensive clinicopathological analysis of CTB and NTM infections.MethodsWe conducted a retrospective analysis of 103 patients diagnosed with cutaneous tuberculosis (CTB) and nontuberculous mycobacteria (NTM) infections at a Beijing dermatology department from January 2000 to January 2024. Demographic, clinical, histological, and laboratory finding data were collected. Diagnostic methods and histopathological examination were recorded. Treatment regimens and outcomes were reviewed. Descriptive statistics were used to summarize demographic and clinical data, and continuous variables expressed as means and standard deviations (SD), and categorical variables as frequencies and percentages. Statistical analyses were conducted using SPSS version 25.0.ResultsThe cohort included 103 patients (40.8% males and 59.2% females), with a mean age of 51.86 years. Common clinical manifestations included nodules (97.1%), erythema (74.8%), and plaques (68.9%). Histological examination revealed hyperkeratosis (68.9%), parakeratosis (23.3%), and extensive neutrophil infiltration (95.1%) were observed. Acid fast bacteria (AFB) stains and nucleic acid tests exhibited respective positivity rates of 39.6% and 52.3%, respectively. Most patients were treated with a combination of three drugs; 77.1% of patients showed improvement, with the cure rate for CTB being 20.0%.DiscussionThis study highlights the diverse clinical and histological presentations of CTB and NTM infections, emphasizing the need for comprehensive diagnostic approaches. The variability in treatment regimens reflects the complex management of these infections.ConclusionThe implementation of advanced molecular techniques and standardized treatment protocols is imperative for enhancing diagnostic precision and therapeutic outcomes.
Differential association of abdominal, liver, and epicardial adiposity with anthropometry, diabetes, and cardiac remodeling in Asians
Authors: Lee Vivian , Han Yiying , Toh Desiree-Faye , Bryant Jennifer A. , Boubertakh Redha , Le Thu-Thao , Chin Calvin W. L. 
Published: August 2024

BackgroundHeterogenous deposition and homeostasis roles of physiologic and ectopic adipose tissues underscore the impact of fat compartmentalization on cardiometabolic risk. We aimed to characterize the distribution of abdominal visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), epicardial adipose tissue (EAT), and liver fat on magnetic resonance imaging (MRI), and evaluate their associations with anthropometric indices and adverse cardiac remodeling.MethodsIn this cross-sectional observational study, 149 Asian adults (57.0 ± 12.8 years; 65% males) with at least one cardiometabolic risk factor underwent multiparametric fat and cardiovascular MRI. Anthropometric indices included body mass index (BMI), waist circumference (WC), waist-hip ratio (WHR), and bioimpedance body fat mass (BFM). Associations between fat depots and anthropometric measures as well as cardiac remodeling features were examined as a single cohort and stratified by type 2 diabetes mellitus (T2DM) status.ResultsVAT and SAT had opposing associations with liver fat and EAT. Therefore the VAT/SAT ratio was explored as an integrated marker of visceral adiposity. VAT/SAT was positively associated with EAT (β=0.35, P&lt;0.001) and liver fat (β=0.32, P=0.003) independent of confounders. Of the anthropometric measurements assessed, only WHR was independently associated with VAT/SAT (β=0.17, P=0.021). Individuals with T2DM had higher VAT and lower SAT compared to those without T2DM, translating to a significantly higher VAT/SAT ratio. EAT volume was independently associated with adverse features of cardiac remodeling: increased left ventricular (LV) mass (β=0.24, P=0.005), larger myocyte volume (β=0.26, P=0.001), increased myocardial fibrosis (β=0.19, P=0.023), higher concentricity (β=0.18, P=0.035), and elevated wall stress (β=−0.18, P=0.023).ConclusionMultiparametric MRI revealed abdominal VAT and SAT have differential associations with anthropometric indices and ectopic fats in a single cohort of Asians at risk of cardiometabolic disease. People with T2DM have expanded VAT and diminished SAT, endorsing the VAT/SAT ratio beyond usual anthropometric measurements as a marker for multiorgan visceral fat composition. Among the fat depots examined, EAT is uniquely associated with adverse cardiac remodeling, suggesting its distinctive cardiometabolic properties and implications.
A Succinct review of strengths, weaknesses, opportunities, and threats (SWOT) analyses, challenges and prospects of solar and wind tree technologies for hybrid power generation
Authors: Mohanaravi Kumaresen , Samykano Mahendran , Pandey Adarsh Kumar , Noor Muhamad Mat , Kadirgama Kumaran 
Published: August 2024

IntroductionThe increasing global demand for sustainable energy solutions highlights the urgency of exploring renewable resources, particularly sunlight, which is abundant and virtually limitless. This study reviews innovative technologies like solar trees, wind trees, and hybrid solar-wind trees, which are emerging as efficient structures for harnessing renewable energy.MethodsA comprehensive SWOT analysis was conducted to evaluate the strengths, weaknesses, opportunities, and threats associated with solar, wind, and hybrid trees. The analysis also considered sustainability aspects, focusing on the efficiency and practicality of these technologies in various settings.ResultsSolar trees mimic natural foliage, utilizing solar modules to convert sunlight into electricity, while wind trees incorporate micro-wind turbines and solar panels, effectively harnessing both wind and solar energy. Hybrid solar-wind trees combine these technologies to provide a consistent energy supply. These structures are compact, cost-effective, and adaptable to urban landscapes.DiscussionChallenges such as land use, aesthetic considerations, and public perception were identified. The review emphasizes the need for future research to optimize configurations and address these challenges, ensuring the successful integration of these technologies into sustainable urban landscapes.ConclusionThis review provides critical insights for renewable energy researchers, particularly in the development of hybrid wind and solar power systems, promoting energy security and climate resilience.
Exploring the efficacy of laser speckle contrast imaging in the stratified diagnosis of rosacea: a quantitative analysis of facial blood flow dynamics across varied regions
Authors: Liao Jin-Feng , Jiang Xue-Mei , Xie Zhen , Lei Hua , Luo Juan , Lv Yu , Liu Gang , Mao Yujie , Song Si-Yuan , Wang Yi 
Published: August 2024

BackgroundRosacea has a high incidence, significantly impacts quality of life, and lacks sufficient diagnostic techniques. This study aimed to investigate the feasibility of laser speckle contrast imaging (LSCI) for measuring facial blood perfusion in patients with rosacea and to identify differences in blood flow among various facial regions associated with different rosacea subtypes.MethodsFrom June to December 2023, 45 patients were recruited, with 9 excluded, leaving 36 subjects: 12 with erythematotelangiectatic rosacea (ETR), 12 with papulopustular rosacea (PPR), and 12 healthy controls. The Think View multispectral imaging analyzer assessed inflammation via gray reading values across the full face and five facial areas: forehead, nose, cheeks, and chin. LSCI measured and analyzed blood perfusion in the same areas. Plasma biomarkers interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α (TNF-α) were tested in different groups.ResultsBoth ETR and PPR groups showed increased average blood perfusion and facial inflammation intensity by gray values compared to controls, with statistically significant differences. Average blood perfusion of ETR and PPR groups showed increased values in the forehead, cheeks, and nose, compared to controls, and the values in the cheeks were statistically different between ETR and PPR. The facial inflammation intensity of the ETR group showed increased values in the forehead and cheeks, and the PPR group showed increased gray values in the forehead, cheeks, nose, and chin compared to controls, and the values for the cheeks, nose, and chin were statistically significantly different between ETR and PPR. Plasma biomarkers IL-6, IL-1β, and TNF-α were significantly elevated in both ETR and PPR groups compared to controls.ConclusionLSCI is a valuable, non-invasive tool for assessing blood flow dynamics in rosacea, providing a data foundation for clinical research. Different rosacea subtypes exhibit distinct lesion distribution and blood flow patterns, and both ETR and PPR could affect all facial areas, particularly the cheeks in ETR and the forehead, nose, and chin in PPR.
Demography of Antarctic krill (Euphausia superba) from the KY1804 austral summer survey in the eastern Indian sector of the Southern Ocean (80 to 150˚E), including specific investigations of the upper surface waters
Authors: Schaafsma Fokje L. , Driscoll Ryan , Matsuno Kohei , Sugioka Rikuto , Driscoll Sara , van Regteren Marin , Sasaki Hiroko , Matsukura Ryuichi , van Franeker Jan Andries , Murase Hiroto 
Published: August 2024

Antarctic krill (Euphausia superba) is a harvested species that has an important role in the Southern Ocean food web. Knowledge on the demography of Antarctic krill is necessary for a better understanding of the distribution of life stages and their relation with predator species. In addition, such information is essential for krill fisheries management by CCAMLR (Commission on the Conservation of Antarctic Marine Living Resources). A large part of the Indian sector of the Southern Ocean is understudied and large-scale krill surveys of this region are scarce. Therefore, a survey was carried out during the austral summer of 2018/2019 on board RV Kaiyo-maru in the region from 80 to 150˚E. Krill was collected using a Rectangular Midwater Trawl (RMT). Previous studies suggest that part of the Antarctic krill population resides in the upper surface of the water column, but traditional trawls and echosounders have not been able to fully investigate this stratum due to sampling constraints. To overcome this knowledge gap, the upper surface (0-2 m) was sampled using a Surface and Under Ice Trawl (SUIT) in addition to the standard survey net. Results show that there were differences in the horizontal and vertical distribution of post-larval krill between the area west and east of approximately 120˚E. These differences coincided with variation in environmental properties. Early calyptopis larvae were found throughout the survey area. Their relatively low numbers suggested ongoing spawning that started early in the season. Juveniles were found mainly in the western side of the sampling area and large densities of this developmental stage were found to reside in the upper two meters of the water column. The quantitative estimation of krill in the upper surface indicated that undersampling this part of the population may influence estimates of, for example, recruitment.
Outcomes of pregnancy in Wilson’s disease: a population-based study from multiple centres of the Han population in China
Authors: Rao Rao , Yu Xu-En , Zhou Zhi-Hua , Shu Shan , Du Yi-Gang , Han Yong-Zhu , Han Yong-Sheng 
Published: August 2024

ObjectivesWilson’s disease is an autosomal recessive disorder related to copper metabolism which mostly patients occurs in adolescents, fertility has become a problem that WD needs to face.MethodsA 21 years retrospective follow up study was conducted and a total of 220 female patients were included to identify patients with outcomes of pregnancy.ResultsUntreated female patients with WD had a spontaneous abortion rate of 44%. During the study period, 146 female patients with WD from multicenter, 75 patients (51.4%) had successful outcomes of pregnancy. Notably, urinary copper levels below 616 μg/24 h were strongly associated with successful pregnancy. The nomogram built on these variables were age, urinary copper, haemoglobin and Child–Pugh classification, internally validated and showed good performance.ConclusionThe spontaneous abortion rate was 44% in untreated females with WD and developed a four-variable risk prediction model to accurately predict the likelihood of a successful pregnancy.
Dynamics alteration of the gut microbiota and faecal metabolomes in very low or extremely low birth weight infants: a Chinese single-center, prospective cohort study
Authors: Liu Ling , Chen Chaohong , Li YeShan , Ao Dang , Wu Jiayuan , Cai Nali , Li Wen , Xiang Min 
Published: August 2024

ObjectiveThe aim of this study is to comprehensively investigate the temporal dynamics of faecal gut microbiota and metabonomics in early postnatal with a focus on very low or extremely low birth weight (VLBW/ELBW) infants.MethodsWe collected faecal samples from 157 VLBW/ELBW infants at three time points: days 1, 14, and 28 in a prospective cohort study. The faecal microbial diversity, abundance, composition, and metabolomic analyses were determined using 16S rRNA sequencing and liquid chromatography tandem mass spectrometry (LC-MS/MS). Microbiome functional analyses were conducted utilizing PICRUSt2. The ecological association networks were employed to investigate the interactions between gut microbiota and identify the core genus within 28 days of birth, as well as to unveil correlations between taxa and metabolites.Result(1) The alpha diversity of gut microbiota significantly decreased from D1 to D28, accompanied by an interrupted trajectory lacking obligate anaerobes. At the phylum level, the 16S RNA sequencing results showed an increase in Proteobacteria and a decrease in Firmicutes and Bacteroidota from D1 to D28. At the genus level, there was a decrease in the relative abundance of Staphylococcus, Acinetobacter and Ureaplasma, with Klebsiella and Enterococcus emerging as the most abundant genera. (2) The analysis revealed a total of 561 metabolic markers that exhibited significant and distinct alterations between D1 and D14. (3) Ecological association networks revealed that the gut microbiota in D1 exhibited a significantly higher degree of microbial interactions compared to those in D14 and D28. Additionally, Enterococcus, Klebsiella, and Enterobacter were major contributors to the co-occurring network at these three time points. (4) Steroid hormone biosynthesis, including tetrahydrocortisone, androsterone glucuronide, androstenedione and etiocholanolone glucuronide, decreased within 28 days after birth.ConclusionWe have successfully demonstrated a significant dysbiosis in the gut microbiota and a subsequent decrease in its diversity within 4 weeks postpartum in VLBW/ELBW infants. Monitoring the gut microbiota of VLBW/ELBW infants and promptly rectifying dysbiosis in the early stages may represent a potential therapeutic strategy.
The gene YEF3 function encoding translation elongation factor eEF3 is partially conserved across fungi
Authors: Maldonado Giovanna , García Alejandra , Herrero Saturnino , Castaño Irene , Altmann Michael , Fischer Reinhard , Hernández Greco 
Published: August 2024

IntroductionTranslation is a fundamental process of life. In eukaryotes, the elongation step of translation is highly conserved and is driven by eukaryotic translation elongation factors (eEF)1A and eEF2. A significant variation of the elongation is the activity of eukaryotic elongation factor (eEF) 3 in Saccharomyces cerevisiae encoded by the gene yeast elongation factor (YEF3) with orthologs in all fungal species, a few algae, and some protists. In S. cerevisiae, YEF3 is an essential gene and eEF3 plays a critical role in translation elongation, as it promotes binding of the ternary complex acylated-Transfer RNA (tRNA)—eEF1A—Guanosine-5'-triphosphate (GTP) to the aminoacyl (A) site of the ribosome, the release of uncharged tRNAs after peptide translocation, and ribosome recycling. Even though YEF3 was discovered more than 40 years ago, eEF3 has been characterized almost exclusively in S. cerevisiae.MethodsWe undertook an in vivo genetic approach to assess the functional conservation of eEF3 across phylogenetically distant fungal species.ResultsWe found that eEF3 from Zygosaccharomyces rouxii and Candida glabrata (both belonging to phylum Ascomycota), Ustilago maydis (phylum Basidiomycota), and Gonapodya prolifera (phylum Monoblepharomycota), but not Aspergillus nidulans (phylum Ascomycota), supported the growth of S. cerevisiae lacking the endogenous YEF3 gene. We also proved that eEF3 is an essential gene in the ascomycetes C. glabrata and A. nidulans.DiscussionGiven that most existing knowledge on fungal translation has only been obtained from S. cerevisiae, our findings beyond this organism showed variability in the elongation process in Fungi. We also proved that eEF3 is essential in pathogenic fungi, opening the possibility of using eEF3 as a target to fight candidiasis.