Test-retest resting-state fMRI in healthy elderly persons with a family history of Alzheimer’s disease
Authors: Orban Pierre , Madjar Cécile , Savard Mélissa , Dansereau Christian , Tam Angela , Das Samir , Evans Alan C. , Rosa-Neto Pedro , Breitner John C.S. , Bellec Pierre ,   The PREVENT-AD Research Group, Aisen Paul , Pascoal Tharick Ali , Anthal Elena , Appleby Melissa , Barkun Alan , Beaudry Thomas , Bellec Pierre , Benbouhoud Fatiha , Bohbot Veronique , Brandt Jason , Breitner John C. S. , Brunelle Céline , Carmo Leopoldina , Cheewakriengkrai Laksanaun , Collins Louis , Courcot Blandine , Couture Doris , Craft Suzanne , Cuello A. Claudio , Dadar Mahsa , Dansereau Christian , Das Samir , Dauar-Tedeschi Marina , Dea Dorothy , Debacker Clément , Desautels René , Desrochers Nicole , Dubuc Sylvie , Duclair Guerda , Dufour Marianne , Eisenberg Mark , El-Khoury Rana , Etienne Pierre , Evans Alan C. , Faubert Anne Marie , Ferdinand Fabiola , Fonov Vladimir S. , Fontaine David , Francoeur Renaud , Frappier Josée , Frenette Joanne , Gauthier Serge , Gervais Valérie , Giles Renuka , Gordon Renee , Hoge Rick , Hyman Bradley T. , Iturria-Medina Yasser , Jack Clifford R. , Kat Justin , Khachaturian Zaven S. , Kliegman Stephanie , Knopman David S. , Kostopoulos Penelope , Labonté Anne , Lafaille-Magnan Marie-Elyse , Lee Tanya , Lepage Claude , Leppert Ilana , Leoutsakos Jeannie-Marie , Madjar Cécile , Mahar Laura , Maltais Jean-Robert , Mathieu Axel , Mathotaarachchi Sulantha , Maultaup Gerhard , Mayrand Ginette , Michaud Diane , Miron Justin , Montine Thomas J. , Morris John C. , Münter Lisa-Marie , Nair Vasavan , Near Jamie , Newbold-Fox Holly , Orban Pierre , Pagé Véronique , Petkova Mirela , Picard Cynthia , Pogossova Galina , Poirier Isabelle , Poirier Judes , Pruessner Jens , Rajah Natasha , Rioux Pierre , Rosa-Neto Pedro , Sager Mark A. , Savard Mélissa , Sperling Reisa A. , Tam Angela , Tariot Pierre N. , Teigner Eduard , Théroux Louise , Thomas Ronald G. , Toussaint Paule-Joanne , Tremblay-Mercier Jennifer , Tuwaig Miranda , Vallée Isabelle , Venogopalan Vinod , Wan Karen , Wang Seqian 
Published: October 2015

AbstractWe present a test-retest dataset of resting-state fMRI data obtained in 80 cognitively normal elderly volunteers enrolled in the “Pre-symptomatic Evaluation of Novel or Experimental Treatments for Alzheimer's Disease” (PREVENT-AD) Cohort. Subjects with a family history of Alzheimer's disease in first-degree relatives were recruited as part of an on-going double blind randomized clinical trial of Naproxen or placebo. Two pairs of scans were acquired ~3 months apart, allowing the assessment of both intra- and inter-session reliability, with the possible caveat of treatment effects as a source of inter-session variation. Using the NeuroImaging Analysis Kit (NIAK), we report on the standard quality of co-registration and motion parameters of the data, and assess their validity based on the spatial distribution of seed-based connectivity maps as well as intra- and inter-session reliability metrics in the default-mode network. This resource, released publicly as sample UM1 of the Consortium for Reliability and Reproducibility (CoRR), will benefit future studies focusing on the preclinical period preceding the appearance of dementia in Alzheimer's disease.