bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance of radiomics in the differential diagnosis of parotid tumors: a systematic review
Authors: Rao Yilin , Ma Yuxi , Wang Jinghan , Xiao Weiwei , Wu Jiaqi , Shi Liang , Guo Ling , Fan Liyuan 
Published: July 2024

PurposeA systematic review and meta-analysis were conducted to evaluate the diagnostic precision of radiomics in the differential diagnosis of parotid tumors, considering the increasing utilization of radiomics in tumor diagnosis. Although some researchers have attempted to apply radiomics in this context, there is ongoing debate regarding its accuracy.MethodsDatabases of PubMed, Cochrane, EMBASE, and Web of Science up to May 29, 2024 were systematically searched. The quality of included primary studies was assessed using the Radiomics Quality Score (RQS) checklist. The meta-analysis was performed utilizing a bivariate mixed-effects model.ResultsA total of 39 primary studies were incorporated. The machine learning model relying on MRI radiomics for diagnosis malignant tumors of the parotid gland, demonstrated a sensitivity of 0.80 [95% CI: 0.74, 0.86], SROC of 0.89 [95% CI: 0.27-0.99] in the validation set. The machine learning model based on MRI radiomics for diagnosis malignant tumors of the parotid gland, exhibited a sensitivity of 0.83[95% CI: 0.76, 0.88], SROC of 0.89 [95% CI: 0.17-1.00] in the validation set. The models also demonstrated high predictive accuracy for benign lesions.ConclusionThere is great potential for radiomics-based models to improve the accuracy of diagnosing benign and malignant tumors of the parotid gland. To further enhance this potential, future studies should consider implementing standardized radiomics-based features, adopting more robust feature selection methods, and utilizing advanced model development tools. These measures can significantly improve the diagnostic accuracy of artificial intelligence algorithms in distinguishing between benign and malignant tumors of the parotid gland.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023434931.
Correlation of time trends of air pollutants, greenspaces and tracheal, bronchus and lung cancer incidence and mortality among the adults in United States
Authors: Zhao Jia , Ren Ruihang , Beeraka Narasimha M. , PA Mahesh , Xue Nannan , Lu Pengfei , Bai Wenhua , Mao Zhihan , PR Hemanth Vikram , Bulygin Kirill V. , Nikolenko Vladimir N. , Fan Ruitai , Liu Junqi 
Published: July 2024

BackgroundTracheal, Bronchus, and Lung (TBL) cancer continues to represent the majority of cancer-related incidence and mortality in United States (U.S.). While air pollutants are considered essential risk factors, both global and national average concentrations of major harmful air pollutants have significantly decreased over the decades. Green space may have a beneficial effect on human health.MethodsWe obtained data on national and state-level burden of TBL cancer, the annual average concentration of main air pollutants, and levels of green spaces in 2007, 2013, and 2019. According to generalized estimating equation (GEE), we examine the associations among incidence and mortality of TBL cancer, air pollutants, and greenspaces, represented by the Normalized Difference Vegetation Index (NDVI) in different age groups with models adjusted with meteorological, and socio-demographic. We observed additional effects of the interaction between the NDVI, Ozone, PM2.5, and other factors, which helped us to interpret and understand our results. Also, we collated states that witnessed net increments in forest coverage and conducted the same analysis separately.ResultsIn our analysis, the majority of associations between NDVI and air pollutants with TBL cancer remained significantly positive, particularly noticeable among individuals aged 20 to 54. However, our findings did not explore air pollution as a potential mediator between greenspace exposure and TBL cancer. While the associations of PM2.5 with TBL cancer remained positive, the other four pollutants showed positive but statistically insignificant associations. Our interaction analysis yielded that there were positive associations between NDVI and ozone, PM2.5, and tobacco use. Max NDVI acts as a protective factor along with high HDI. Additionally, PM2.5 and HDI also showed a negative association. In 18 states with more forest, NDVI acts as a protective factor along with higher health care coverage, better health status, and participation in physical activities.ConclusionIn the state-level of U.S., the effects of total greenspace with TBL cancer are mixed and could be modified by various socio-economic factors. PM2.5 has a direct correlation with TBL cancer and the effects can be influenced by underlying socioeconomic conditions.
The SAR analysis of dietary polyphenols and their antagonistic effects on bortezomib at physiological concentrations
Authors: Van Tran Tran Thi , Chang Hsun-Shuo , Wu Ho-Cheng , Lu Chung-Kuang , Huang Hui-Chi , Korinek Michal , Hsiao Hui-Hua , Yen Chia-Hung 
Published: July 2024

Background: Bortezomib (BTZ), a primary treatment for MM, but its effectiveness can be reduced by interactions with vicinal diol moieties (VDMs) in polyphenols. Despite this, it’s debated whether BTZ therapy necessitates avoiding polyphenol-rich products, given the low bioavailability of polyphenols. Additionally, it remains unclear whether the structure of polyphenols contributes to their BTZ antagonism. Therefore, our study aims to unravel the structure-activity relationship of dietary polyphenols and their BTZ antagonism at daily diet-achievable physiological concentrations.Methods: We assessed the antagonistic effects of 25 polyphenols against BTZ using cell viability assays in RPMI 8226 cells. ChemGPS-NP helped analyze the structural similarity. Additionally, long-term cytotoxicity assays evaluated these effects at physiologically relevant concentrations.Results: By cell viability assays, we found a positive correlation between the number of VDMs in gallotannins and their BTZ antagonism. Moreover, the origin and configuration of VDMs, rather than the total VDM concentration, play a pivotal role in the combined antagonistic effects against BTZ in gallotannins. Additionally, ChemGPS-NP analysis indicated that the aromaticity and C-3 hydroxyl group in flavonoids’ C-rings enhance their BTZ antagonism. Finally, long-term cytotoxicity assays reveal that gallic acid (GA), epigallocatechin (EGC), and epigallocatechin gallate (EGCG), at their physiological concentrations—attainable through tea consumption—significantly and synergistically antagonize BTZ.Conclusion: Due to the potential for these polyphenols to reduce the effectiveness of BTZ, it is advisable for MM patients undergoing BTZ treatment to reduce their consumption of foods high in VDM-containing polyphenols.
Bibliometric and visualized analysis of ultrasound combined with microbubble therapy technology from 2009 to 2023
Authors: Tu Bin , Li Yan , Wen Wen , Liu Jian 
Published: July 2024

BackgroundIn recent years, with the rapid advancement of fundamental ultrasonography research, the application of ultrasound in disease treatment has progressively increased. An increasing body of research indicates that microbubbles serve not only as contrast agents but also in conjunction with ultrasound, enhancing cavitation effects and facilitating targeted drug delivery, thereby augmenting therapeutic efficacy. The objective of this study is to explore the current status and prevailing research trends in this field from 2009 to 2023 through bibliometric analysis and to forecast future developmental trajectories.MethodsWe selected the Science Citation Index Expanded (SCI-Expanded) from the Web of Science Core Collection (WOSCC) as our primary data source. On 19 January 2024, we conducted a comprehensive search encompassing all articles and reviews published between 2009 and 2023 and utilized the bibliometric online analysis platform, CiteSpace and VOSviewer software to analyze countries/regions, institutions, authors, keywords, and references, used Microsoft Excel 2021 to visualize the trends of the number of articles published by year.ResultsBetween 1 January 2009, and 31 December 2023, 3,326 publications on ultrasound combined with microbubble therapy technology were included. There were a total of 2,846 articles (85.6%) and 480 reviews (14.4%) from 13,062 scholars in 68 countries/regions published in 782 journals. China and the United States emerged as the primary contributors in this domain. In terms of publication output and global institutional collaboration, the University of Toronto in Canada has made the most significant contribution to this field. Professor Kullervo Hynynen has achieved remarkable accomplishments in this area. Ultrasound in Medicine and Biology is at the core of the publishing of research on ultrasound combined with microbubble therapy technology. Keywords such as “sonodynamic therapy,” “oxygen,” “loaded microbubbles” and “Alzheimer’s disease” indicate emerging trends in the field and hold the potential to evolve into significant areas of future investigation.ConclusionThis study provides a summary of the key contributions of ultrasound combined with microbubble therapy to the field’s development over the past 15 years and delves into the historical underpinnings and contemporary trends of ultrasound combined with microbubble therapy technology, providing valuable guidance for researchers.
The relationship between effort-reward imbalance and quality of working life among medical caregivers: mediating effects of job burnout
Authors: Qi Huang , Hongyan Sun , Song He , Zhihang Zhou , Ruiyin Huang , Youjia Ma , Xia Li 
Published: July 2024

BackgroundTo determine the relationship between effort-reward imbalance (ERI) and quality of working life (QWL) among medical caregivers and the mediating role of job burnout.MethodsThis was a cross-sectional survey. A total of 787 medical caregivers at seven hospitals from Sichuan and Chongqing, China, between May to September 2023 were included in this observational study. The General Information Questionnaire, Effort-Reward Imbalance Questionnaire (ERI), Maslach Burnout Inventory-General Survey (MBI-GS), and Quality of Working Life Scale (QWL7-32) were used for data collection. SPSS 26.0 and PROCESSv3.3 were used for all data analyses, including descriptive statistics.ResultsA total of 820 questionnaires were distributed, of which only 787 were valid (return rate; 95.98%). The QWL score of medical caregivers was 126.94 ± 16.69. However, QWL scores were significantly different depending on age, number of children, family support status, department, years of experience, night shift status, number of night shifts per month, number of hours worked per day, monthly income, and occurrence of errors or adverse events (p &lt; 0.05). Furthermore, job burnout and ERI were negatively correlated with QWL (p &lt; 0.01). Job burnout mediated (95% CI = -0.365, −0.260) the relationship between ERI and QWL, accounting for 58.65% of the total effect.ConclusionMedical caregivers have a medium level of QWL. Job burnout partially mediates the relationship between ERI and QWL. Medical caregiver managers can improve QWL by directly intervening in occupational stress and indirectly intervening in job burnout.
Identifying the most crucial factors associated with depression based on interpretable machine learning: a case study from CHARLS
Authors: Li Rulin , Wang Xueyan , Luo Lanjun , Yuan Youwei 
Published: July 2024

BackgroundDepression is one of the most common mental illnesses among middle-aged and older adults in China. It is of great importance to find the crucial factors that lead to depression and to effectively control and reduce the risk of depression. Currently, there are limited methods available to accurately predict the risk of depression and identify the crucial factors that influence it.MethodsWe collected data from 25,586 samples from the harmonized China Health and Retirement Longitudinal Study (CHARLS), and the latest records from 2018 were included in the current cross-sectional analysis. Ninety-three input variables in the survey were considered as potential influential features. Five machine learning (ML) models were utilized, including CatBoost and eXtreme Gradient Boosting (XGBoost), Gradient Boosting decision tree (GBDT), Random Forest (RF), Light Gradient Boosting Machine (LightGBM). The models were compared to the traditional multivariable Linear Regression (LR) model. Simultaneously, SHapley Additive exPlanations (SHAP) were used to identify key influencing factors at the global level and explain individual heterogeneity through instance-level analysis. To explore how different factors are non-linearly associated with the risk of depression, we employed the Accumulated Local Effects (ALE) approach to analyze the identified critical variables while controlling other covariates.ResultsCatBoost outperformed other machine learning models in terms of MAE, MSE, MedAE, and R2metrics. The top three crucial factors identified by the SHAP were r4satlife, r4slfmem, and r4shlta, representing life satisfaction, self-reported memory, and health status levels, respectively.ConclusionThis study demonstrates that the CatBoost model is an appropriate choice for predicting depression among middle-aged and older adults in Harmonized CHARLS. The SHAP and ALE interpretable methods have identified crucial factors and the nonlinear relationship with depression, which require the attention of domain experts.
Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort
Authors: Cong Enzhao , Zhong Yingyan , Wu Mengyue , Chen Haiying , Cai Yiyun , Ling Zheng , Wang Yun , Wen Hui , Hu Yao , Zhang Huifeng , Li Yan , Liu Xiaohua , Zhong Pingfang , Lai Weijie , Xu Yifeng , Wu Yan 
Published: July 2024

IntroductionSymptoms during the onset of major depressive disorder [MDD] and bipolar disorder type II [BD-II] are similar. The difference of hippocampus subregion could be a biological marker to distinguish MDD from BD-II.MethodsWe recruited 61 drug-naïve patients with a first-episode MDD and BD-II episode and 30 healthy controls (HC) to participate in a magnetic resonance imaging [MRI] study. We built a general linear model (one-way analysis of covariance) with 22 hippocampal subfields and two total hippocampal volumes as dependent variables, and the diagnosis of MDD, BD-II, and HC as independent variables. We performed pair-wise comparisons of hippocampal subfield volumes between MDD and HC, BD-II and MDD, BD-II and HC with post hoc for primary analysis.ResultsWe identified three regions that differed significantly in size between patients and controls. The left hippocampal fissure, the hippocampal–amygdaloid transition area (HATA), and the right subiculum body were all significantly larger in patients with MDD compared with the HC. In the onset of first-episode of MDD, the hippocampal volume increased significantly, especially on the left side comparing to HC. However, we found differences between MDD and BD-II were not statistically significant. The volume of the left HATA and right subiculum body in BD-II was larger.ConclusionsThe sample size of this study is relatively small, as it is a cross-sectional comparative study. In both MDD and BD-II groups, the volume of more left subregions appeared to increase. The left subregions were severely injured in the development of depressive disorder.
Effectiveness of biosimilar pegfilgrastim in patients with lymphoma after high-dose chemotherapy and autologous stem cell transplantation: a real-life study
Authors: Loteta Barbara , Pitino Annalisa , Pitea Martina , Alati Caterina , Tripepi Giovanni , Mico' Maria Caterina , Pellicano' Maria , Cogliandro Francesca , Porto Gaetana , Policastro Giorgia , Utano Giovanna , Delfino Ilaria Maria , Sgarlata Annalisa , Scopelliti Anna , Idato Aurora , Laenza Giovanni , Altomonte Maria , D'Arrigo Graziella , Gori Mercedes , Martino Massimo 
Published: July 2024

ObjectivesTo evaluate the efficacy of biosimilar (BIO) pegfilgrastim (PEG) in lymphoma patients after autologous stem cell transplantation (ASCT).Methods86 consecutive lymphoma patients who received BIO/PEG after ASCT were assessed. The primary endpoints of this study were the incidence of febrile neutropenia (FN) and time to neutrophil engraftment.ResultsMost patients were males (67.4%) with a median age of 48 years. FN occurred in 66 patients (76.7%), and most of the fever was grade 1-2. The median time to neutrophil engraftment was 9 days. The incidence of FN differs based on lymphoma type (p-value &lt;0.01) and was higher in non-Hodgkin lymphoma (NHL) than in Hodgkin Lymphoma (HL). No statistical difference was found between NHL and HL regarding the time to reach the neutrophil engraftment. Hospitalization lasted from a minimum of 9 to a maximum of 34 days. The restricted mean time to discharge was 15.9 days (95%CI 14-16), without differences based on lymphoma type.ConclusionAlthough the study has the significant limitation of not being randomized and not having a control arm, it highlights the efficacy and safety of a BIO-PEG formulation in patients with Lymphoma and undergoing ASCT.
Multiple pathogens co-exposure and associated risk factors among cattle reared in a wildlife-livestock interface area in Kenya
Authors: Manyenya Sophina , Nthiwa Daniel , Lutta Harrison Osundwa , Muturi Mathew , Nyamota Richard , Mwatondo Athman , Watene Grace , Akoko James , Bett Bernard 
Published: July 2024

IntroductionUnderstanding multi-pathogen infections/exposures in livestock is critical to inform prevention and control measures against infectious diseases. We investigated the co-exposure of foot-and-mouth disease virus (FMDV), Brucella spp., Leptospira spp., and Coxiella burnetii in cattle in three zones stratified by land use change and with different wildlife-livestock interactions in Narok county, Kenya. We also assessed potential risk factors associated with the transmission of these pathogens in cattle.MethodsWe identified five villages purposively, two each for areas with intensive (zone 1) and moderate wildlife-livestock interactions (zone 2) and one for locations with low wildlife-livestock interactions (zone 3). We sampled 1,170 cattle from 390 herds through a cross-sectional study and tested the serum samples for antibodies against the focal pathogens using enzyme-linked immunosorbent assay (ELISA) kits. A questionnaire was administered to gather epidemiological data on the putative risk factors associated with cattle’s exposure to the investigated pathogens. Data were analyzed using the Bayesian hierarchical models with herd number as a random effect to adjust for the within-herd clustering of the various co-exposures among cattle.ResultsOverall, 88.0% (95% CI: 85.0–90.5) of the cattle tested positive for at least one of the targeted pathogens, while 41.7% (95% CI: 37.7–45.8) were seropositive to at least two pathogens. FMDV and Brucella spp. had the highest co-exposure at 33.7% (95% CI: 30.9–36.5), followed by FMDV and Leptospira spp. (21.8%, 95% CI: 19.5–24.4), Leptospira spp. and Brucella spp. (8.8%, 95% CI: 7.2–10.6), FMDV and C. burnetii (1.5%, 95% CI: 0.7–2.8), Brucella spp. and C. burnetii (1.0%, 95% CI: 0.3–2.2), and lowest for Leptospira spp. and C. burnetii (0.3%, 95% CI: 0.0–1.2). Cattle with FMDV and Brucella spp., and Brucella spp. and Leptospira spp. co-exposures and those simultaneously exposed to FMDV, Brucella spp. and Leptospira spp. were significantly higher in zone 1 than in zones 2 and 3. However, FMDV and Leptospira spp. co-exposure was higher in zones 1 and 2 than zone 3.Discussion/conclusionWe recommend the establishment of a One Health surveillance system in the study area to reduce the morbidity of the targeted zoonotic pathogens in cattle and the risks of transmission to humans.
Risk Management Methodology in the Business Processes of PJSC Gazprom
Authors: Сиргалина Г.Т. 
Published: July 2024

В статье выделены риски компании ПАО Газпром по сегментам бизнеса, проведена количественная и качественная оценка рисков в бизнес-процессах компании. Предложены схема использования методов снижения рисков и матрица выбора управления рисками в зависимости от параметров.
The article identifies the risks of PJSC Gazprom by business segments, conducted a quantitative and qualitative assessment of risks in the companys business processes. A scheme of using risk reduction methods and a risk management selection matrix depending on parameters are proposed.
Anti-globalization Trends in the Activities of Transnational Corporations
Authors: Козлова Ж.М. , Дронова О.Б. 
Published: July 2024

Проведенный в статье отраслевой анализ ТНК из топ-100 выявил снижение доли добывающих и обрабатывающих производств в развитых странах. Показана общая тенденция расширения бизнеса в автомобильной и технологичных отраслях. Авторы статьи соглашаются с тенденциями замедления глобализационных процессов и приводят несколько примеров. Другая тенденция это стремительный рост цифровых фирм в топ-100 международных ТНК. В статье также приведены способы влияния цифровизации на снижение глобализационных процессов.
The industry analysis of TNC from the TOP-100 conducted in the article revealed a decrease in the share of mining and manufacturing industries in developed countries. The general tendency of business expansion in the automotive and technological sectors is shown. The author of the article agrees with the trends of the slowdown of globalization processes and gives several examples. Another trend is the rapid growth of digital firms in the TOP-100 international multinationals. The article also describes the ways in which digitalization affects the reduction of globalization processes.
Subsidizing Lending to Agricultural Small Businesses
Authors: Старкова О.Я. 
Published: July 2024

В статье рассматриваются проблемы субсидирования части процентной ставки по банковским кредитам малого предпринимательства на селе. Обосновывается необходимость государственной поддержки кредитования малого бизнеса. Проведен анализ текущего остатка субсидий по льготному кредитованию. Проведено ранжирование федеральных округов РФ по остаткам субсидий. Рассмотрен план предоставления субсидий на 2020 год.
The article deals with the problems of subsidizing part of the interest rate on bank loans to small businesses in rural areas. Necessity of the state support of crediting of small business is proved. The analysis of the current balance of subsidies for concessional lending. The ranking of the federal districts of the Russian Federation on the balance of subsidies. The plan is to provide subsidies for 2020.
Labor Migration Management (on the Example of the Russian Federation)
Authors: Якшибаева Г.В. 
Published: July 2024

В статье рассматривается авторский подход к планово-рыночному регулированию трудовой миграции, включающий в себя следующие этапы: планирование, реализация и контроль. Выявляются сильные и слабые стороны, возможности и угрозы данного подхода. Разработаны концептуальные основы планово-рыночного регулирования трудовой миграции.
The article deals with the authors approach to planning and market regulation of labor migration, which includes the following stages: planning, implementation and control. The strengths and weaknesses, opportunities and threats of this approach are identified. Conceptual bases of planned market regulation of labor migration are developed.