bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ambient Synthesis of Vanadium‐Based Prussian Blue Analogues Nanocubes for High‐Performance and Durable Aqueous Zinc‐Ion Batteries with Eutectic Electrolytes
Authors: Shi Yuxin , Yang Biao , Song Gongjing , Chen Zhidong , Shakouri Mohsen , Zhou Wenfeng , Zhang Xiaoxing , Yuan Guoqiang , Pang Huan 
Published: August 2024

AbstractPrussian blue analogues (PBAs) have been widely studied in aqueous zinc‐ion batteries (AZIBs) due to the characteristics of large specific surface area, open aperture, and straightforward synthesis. In this work, vanadium‐based PBA nanocubes were firstly prepared using a mild in situ conversion strategy at room temperature without the protection of noble gas. Benefiting from the multiple‐redox active sites of V3+/V4+, V4+/V5+, and Fe2+/Fe3+, the cathode exhibited an excellent discharge specific capacity of 200 mAh g−1 in AZIBs, which is much higher than those of other metal‐based PBAs nanocubes. To further improve the long‐term cycling stability of the V‐PBA cathode, a high concentration water‐in‐salt electrolyte (4.5 M ZnSO4+3 M Zn(OTf)2), and a water‐based eutectic electrolyte (5.55 M glucose+3 M Zn(OTf)2) were designed to successfully inhibit the dissolution of vanadium and improve the deposition of Zn2+ onto the zinc anode. More importantly, the assembled AZIBs maintained 55 % of their highest discharge specific capacity even after 10000 cycles at 10 A g−1 with superior rate capability. This study provides a new strategy for the preparation of pure PBA nanostructures and a new direction for enhancing the long‐term cycling stability of PBA‐based AZIBs at high current densities for industrialization prospects.
Metal‐Ligand Bonds Based Reprogrammable and Re‐Processable Supramolecular Liquid Crystal Elastomer Network
Authors: Zhou Xiaorui , Jin Binjie , Zhu Zhan , Wu Jingjun , Zhao Qian , Chen Guancong 
Published: August 2024

AbstractDynamic covalent bonds endow liquid crystal elastomers (LCEs) with network rearrangeability, facilitating the fixation of mesogen alignment induced by external forces and enabling reversible actuation. In comparison, the bond exchange of supramolecular interactions is typically too significant to stably maintain the programmed alignment, particularly under intensified external stimuli. Nevertheless, remaking and recycling of supramolecular interaction‐based polymer networks are more accessible than those based on dynamic covalent bonds, as the latter are difficult to completely dissociate. Thus, preparing an LCE that possesses both supramolecular‐like exchangeability and covalent bond‐level stability remains a significant challenge. In this work, we addressed this issue by employing metal‐ligand bonds as the crosslinking points of LCE networks. As such, mesogen alignment can be repeatedly encoded through metal‐ligand bond exchange and stably maintained after programming, since the bond exchange rate is sufficiently slow when the programming and actuation temperatures are below the bond dissociation temperature. More importantly, the metal‐ligand bonds can be completely dissociated at high temperatures, allowing the LCE network to be dissolved in a solvent and reshaped into desired geometries via solution casting. Building on these properties, our LCEs can be fabricated into versatile actuators, such as reversible folding origami, artificial muscles, and soft robotics.
Synthesis of Rod‐Like Sb2Se3@MWCNT as Conductive‐Additive Free Anode for Sodium‐Ion Batteries
Authors: Jung Taejung , Jin Youngho , Ha Moon Joon , Seong Honggyu , Kim Geongil , Yoo Hyerin , Lee Seunghui , Kwon Seung‐Ryong , Kuk Kim Sung , Choi Jaewon 
Published: August 2024

AbstractAntimony selenide (Sb2Se3) is a promising electrode material for sodium‐ion batteries (SIBs) due to its high theoretical capacity. However, volume expansion during sodiation/desodiation and the low conductivity of Sb2Se3 reduce the electrochemical performance. Herein, we synthesized Sb2Se3 nanorods (NRs) and combined them with multi‐walled carbon nanotubes (MWCNTs) using one‐step composite process to address these issues. MWCNTs can accommodate volume expansion and provide high conductivity. The fabricated Sb2Se3 NRs@MWCNT electrode exhibits improved cycle performance and cyclic stability without additional conductive carbons. The Sb2Se3 NRs@MWCNT electrode showed an enhanced specific capacity of 440 mAhg−1 at a current density of 0.1 Ag−1, compared to 220 mAhg−1 for the Sb2Se3 NRs electrode. Additionally, it exhibited good stability at high current density. The in‐situ electrochemical impedance spectroscopy (EIS) and Galvanostatic intermittent titration technique (GITT) were used to estimate the electrochemical properties and kinetics of Sb2Se3 NRs@MWCNT. These results showed that Sb2Se3 NRs@MWCNT have the potential as a conductive‐free anode material in SIBs.
Insights into the mechanisms, regulation, and therapeutic implications of extracellular matrix stiffness in cancer
Authors: Zhang Ximo , Al‐Danakh Abdullah , Zhu Xinqing , Feng Dan , Yang Linlin , Wu Haotian , Li Yingying , Wang Shujing , Chen Qiwei , Yang Deyong 
Published: August 2024

AbstractThe tumor microenvironment (TME) is critical for cancer initiation, growth, metastasis, and therapeutic resistance. The extracellular matrix (ECM) is a significant tumor component that serves various functions, including mechanical support, TME regulation, and signal molecule generation. The quantity and cross‐linking status of ECM components are crucial factors in tumor development, as they determine tissue stiffness and the interaction between stiff TME and cancer cells, resulting in aberrant mechanotransduction, proliferation, migration, invasion, angiogenesis, immune evasion, and treatment resistance. Therefore, broad knowledge of ECM dysregulation in the TME might aid in developing innovative cancer therapies. This review summarized the available information on major ECM components, their functions, factors that increase and decrease matrix stiffness, and related signaling pathways that interplay between cancer cells and the ECM in TME. Moreover, mechanotransduction alters during tumorogenesis, and current drug therapy based on ECM as targets, as well as future efforts in ECM and cancer, are also discussed.
Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response
Authors: Zhang Hao , Fu Li , Leiliang Xinwen , Qu Chunrun , Wu Wantao , Wen Rong , Huang Ning , He Qiuguang , Cheng Quan , Liu Guodong , Cheng Yuan 
Published: August 2024

AbstractThe intratumoral microbiome (TM) refers to the microorganisms in the tumor tissues, including bacteria, fungi, viruses, and so on, and is distinct from the gut microbiome and circulating microbiota. TM is strongly associated with tumorigenesis, progression, metastasis, and response to therapy. This paper highlights the current status of TM. Tract sources, adjacent normal tissue, circulatory system, and concomitant tumor co‐metastasis are the main origin of TM. The advanced techniques in TM analysis are comprehensively summarized. Besides, TM is involved in tumor progression through several mechanisms, including DNA damage, activation of oncogenic signaling pathways (phosphoinositide 3‐kinase [PI3K], signal transducer and activator of transcription [STAT], WNT/β‐catenin, and extracellular regulated protein kinases [ERK]), influence of cytokines and induce inflammatory responses, and interaction with the tumor microenvironment (anti‐tumor immunity, pro‐tumor immunity, and microbial‐derived metabolites). Moreover, promising directions of TM in tumor therapy include immunotherapy, chemotherapy, radiotherapy, the application of probiotics/prebiotics/synbiotics, fecal microbiome transplantation, engineered microbiota, phage therapy, and oncolytic virus therapy. The inherent challenges of clinical application are also summarized. This review provides a comprehensive landscape for analyzing TM, especially the TM‐related mechanisms and TM‐based treatment in cancer.
DEPDC1B: A novel tumor suppressor gene associated with immune infiltration in colon adenocarcinoma
Authors: Zhu Dandan , Feng Huolun , Zhang Zhixiong , Li Jiaqi , Li Yong , Hou Tieying 
Published: August 2024

AbstractBackgroundRecent research indicates a positive correlation between DEP structural domain‐containing 1B (DEPDC1B) and the cell cycle in various tumors. However, the role of DEPDC1B in the infiltration of the tumor immune microenvironment (TIME) remains unexplored.MethodsWe analyzed the differential expression and prognostic significance of DEPDC1B in colon adenocarcinoma (COAD) using the R package “limma” and the Gene Expression Profiling Interactive Analysis (GEPIA) website. Gene set enrichment analysis (GSEA) was employed to investigate the functions and interactions of DEPDC1B expression in COAD. Cell Counting Kit‐8 (CCK‐8) assays and colony formation assays were utilized to assess the proliferative function of DEPDC1B. Correlations between DEPDC1B expression and tumor‐infiltrating immune cells, immune checkpoints, tumor mutational burden (TMB), and microsatellite instability (MSI) status were examined using Spearman correlation analysis and CIBERSORT.ResultsDEPDC1B was highly expressed in COAD. Elevated DEPDC1B expression was associated with lower epithelial‐to‐mesenchymal transition (EMT) and TNM stages, leading to a favorable prognosis. DEPDC1B mRNA was prominently expressed in COAD cell lines. CCK‐8 and colony formation assays demonstrated that DEPDC1B inhibited the proliferation of COAD cells. Analysis using the CIBERSORT database and Spearman correlation revealed that DEPDC1B correlated with four types of tumor‐infiltrating immune cells. Furthermore, high DEPDC1B expression was linked to the expression of PD‐L1, CTLA4, SIGLEC15, PD‐L2, TMB, and MSI‐H. High DEPDC1B expression also indicated responsiveness to anti‐PD‐L1 immunotherapy.ConclusionsDEPDC1B inhibits the proliferation of COAD cells and positively regulates the cell cycle, showing a positive correlation with CCNB1 and PBK expression. DEPDC1B expression in COAD is associated with tumor‐infiltrating immune cells, immune checkpoints, TMB, and MSI‐H in the tumor immune microenvironment. This suggests that DEPDC1B may serve as a novel prognostic marker and a potential target for immunotherapy in COAD.
Leaving the parental home, cohabitation, and marriage after a hematologic malignancy in childhood—A register‐based cohort study from the SALiCCS research program
Authors: Korhonen Liisa , Mogensen Hanna , Erdmann Friederike , Feychting Maria , Frederiksen Line Elmerdahl , Hirvonen Elli , Krøyer Anja , Kyrönlahti Anniina , Malila Nea , Pedersen Camilla , Pitkäniemi Janne , Talbäck Mats , Taskinen Mervi , Winther Jeanette Falck , Madanat‐Harjuoja Laura 
Published: August 2024

AbstractIntroductionTransitioning to adulthood often involves achieving independence from the parental home. We assessed whether the likelihood of leaving the parental home, cohabitation, and marriage was similar between patients who experienced a hematologic malignancy at a young age and their peers.MethodsWe identified 11,575 patients diagnosed with a hematologic malignancy under the age of 20 years between 1971 and 2011 in Denmark, Finland, and Sweden, 57,727 country‐, age‐, and sex‐matched population comparisons and 11,803 sibling comparisons and obtained annual information on family and marital status by linking to the statistical institute databases. Hazard ratios (HR) for leaving the parental home, cohabitation and marriage were estimated using Cox proportional hazards modeling.ResultsYoung adults with a history of a hematologic malignancy were slightly less likely to leave the parental home (HR 0.89; 95% confidence interval [CI] 0.86–0.92; HR 0.87 [95% CI 0.82–0.92]), cohabit with a nonmarital partner (HR 0.83 [95%CI 0.78–0.87]; HR 0.84 [95% CI 0.77–0.92]) and be married (HR 0.87 [95% CI 0.82–0.91]; HR 0.86 [95% CI 0.79–0.93]), compared with population comparisons and siblings, respectively.ConclusionsOur findings provide reassurance that young adults with a history of a hematologic malignancy show only a slight decrease in their likelihood of gaining independence from their childhood family and forming close interpersonal relationships compared to peers. While most patients are coping well in the long term, integrating structured psychosocial support into long‐term follow‐up is recommended to facilitate a timely and adequate transition into adulthood.
In Vitro and In Silico Evaluation of the Leishmanicidal and Trypanocidal Activities of Lignan Methylpiperitol Isolated from Persea Fulva
Authors: Alves Reis Isabella Mary , da Silva Girliane Regina , de Mattos Oliveira Larissa , Coelho dos Santos Junior Manoelito , Sarmento da Silva Tania Maria , Curcino Vieira Ivo José , Braz‐Filho Raimundo , Romanelli Maiara Maria , Amaral Maiara , Tempone Andre Gustavo , Ghilardi Lago João Henrique , Branco Alexsandro 
Published: August 2024

AbstractNeglected Tropical Diseases are a significant concern as they encompass various infections caused by pathogens prevalent in tropical regions. The limited and often highly toxic treatment options for these diseases necessitate the exploration of new therapeutic candidates. In the present study, the lignan methylpiperitol was isolated after several chromatographic steps from Persea fulva L. E. Koop (Lauraceae) and its leishmanicidal and trypanocidal activities were evaluated using in vitro and in silico approaches. The chemical structure of methylpiperitol was defined by NMR and MS spectral data analysis. The antiprotozoal activity of methylpiperitol was determined in vitro and indicated potency against trypomastigote forms of Trypanosoma cruzi (EC50 of 4.5±1.1 mM) and amastigote forms of Leishmania infantum (EC50 of 4.1±0.5 mM), with no mammalian cytotoxicity against NCTC cells (CC50>200 mM). Molecular docking studies were conducted using six T. cruzi and four Leishmania. The results indicate that for the molecular target hypoxanthine phosphoribosyl transferase in T. cruzi and piteridine reductase 1 of L. infatum, the methylpiperitol obtained better results than the crystallographic ligand. Therefore, the lignan methylpiperitol, isolated from P. fulva holds potential for the development of new prototypes for the treatment of Neglected Tropical Diseases, especially leishmaniasis.
Suture closure AFtEr large bore vein access (SAFE‐VEIN): A randomized, prospective study of the efficacy and safety of venous closure device
Authors: Ali Mahmoud , Masood Faisal , Erickson Lynn , Adefisoye James , Kanani Jim , Walczak Sara , Ajam Tarek , Kieu Andy , Premjee Mohammed , Jan M. Fuad , Allaqaband Suhail Q. , Bajwa Tanvir , Khitha Jayant , Zilinski Jodi , Jahangir Arshad , Djelmami‐Hani Mohamed , Sra Jasbir , Niazi Imran , Mortada M. Eyman 
Published: August 2024

AbstractBackgroundPerclose ProGlide (PPG) Suture‐Mediated Closure System™ is safe and can reduce time to hemostasis following procedures requiring arterial access.AimsWe aimed to compare PPG to figure of 8 suture in patients who underwent interventional catheter procedures requiring large bore venous access (LBVA) (≥13 French).MethodsIn this physician‐initiated, randomized, single‐center study [clinicaltrials.gov ID: NCT04632641], single‐stick venous access was obtained under ultrasound guidance. Eligible patients were randomized 1:1, and 100 subjects received allocated treatment to either PPG (n = 47) or figure of 8 suture (n = 53). No femoral arterial access was used in any patient. Primary outcomes were time to achieve hemostasis (TTH) and time to ambulation (TTA). Secondary outcomes were time to discharge (TTD) and vascular‐related complications and mortality. Wilcoxon rank‐sum test was used to compare TTH, TTA, and TTD.ResultsTTH (minutes) was significantly lower in PPG versus figure of 8 suture [median, (Q1, Q3)] [7 (2,10) vs. 11 (10,15) respectively, p < 0.001]. TTA (minutes) was significantly lower in PPG compared to figure of 8 suture [322 (246,452) vs. 403 (353, 633) respectively, p = 0.005]. TTD (minutes) was not significantly different between the PPG and figure of 8 suture arms [1257 (1081, 1544) vs. 1338 (1171,1435), p = 0.650]. There was no difference in minor bleeding or access site hematomas between both arms. No other vascular complications or mortality were reported.ConclusionPPG use had lower TTH and TTA than figure of 8 suture in a population of patients receiving LBVA procedures. This may encourage same‐day discharge in these patients.
N‐Halosuccinimide‐CeCl3 Transient Charge‐Transfer Complexes as Semi Heterogeneous Photocatalyst in Cyclization of N‐Propargylamides
Authors: Sahoo Sathi , Dinda Tarun Kumar , Mal Prasenjit 
Published: August 2024

AbstractIn this work, we used photoinert anhydrous cerium(III) chloride, to form a transient charge‐transfer (CT) complex with NXS (N‐bromosuccinimide or NBS and N‐iodosuccinimide or NIS) in acetonitrile. These transient CT complexes acted as a semi‐heterogeneous photocatalyst. These complexes allowed the Ce(III) ions to absorb light, turning them into strong electron donors that transferred electrons to NXS. This created halide radicals from NXS radical anions, helping to turn N‐propargylamides into oxazole aldehydes. Experiments with DMPO and spin‐trapping showed that a radical‐based mechanism followed a single electron transfer (SET) pathway. Notably, CeCl3 was reused after the reaction without much decomposition, as it was regenerated and separated through simple filtration.
Highly Active Immobilized Catalyst for Ethylene Polymerization: Neutral Single Site Y(III) Complex Bearing Bulky Silylallyl Ligand
Authors: Chiari Vittoria , Rouge Pascal , Taam Manel , Dugas Pierre‐Yves , Pannier Gaëlle , Boyron Olivier , Szeto Kai C. , de Mallmann Aimery , Boisson Christophe , Taoufik Mostafa 
Published: August 2024

AbstractExploring the surface organometallic chemistry on silica of highly electrophilic yttrium complexes is a relatively uncommon endeavor, particularly when focusing on tris‐alkyl complexes characterized by Y−C σ‐alkyl bonds. A drawback with this class of complexes once grafted on silica, is the frequent occurrence of alkyl transfer by ring opening of siloxane groups, resulting in a mixture of species. Herein, we employed a more stable homoleptic yttrium allyl complex bearing bulky η3‐1,3‐bis(trimethylsilyl)allyl ligand to limit this transfer reaction. This strategy has been validated by comparing the reactivity between [Y{ η3‐1,3‐C3H3(SiMe3)2}3] and [Y(o‐CH2PhNMe2)3] with SiO2–700, where the undesired alkyl transfer reaction occurred for [Y(o‐CH2PhNMe2)3] leading to a bipodal [(≡SiO)2Y(o‐CH2PhNMe2)] as major surface species, 2, while [Y{ η 3‐1,3‐C3H3(SiMe3)2}3] resulted selectively in a monopodal species, [(≡SiO)Y{η3‐1,3‐C3H3(SiMe3)2}2], 1. The materials obtained were characterized by DRIFT, solid state NMR, mass balance analysis and EXAFS. Catalyst 1 showed high activity compared to 2 in ethylene polymerization. The catalytic performance of this neutral catalyst 1 was extended to pre‐industrial scale in the presence of hydrogen and 1‐hexene. An unprecedented activity, up to 7400 gPE gcat−1 h−1 was obtained even with very low concentration of scavenger AliBu3 (TIBA/Y=1.2). The obtained HDPE exhibited desired spherical particle morphology with broad molar mass distribution.
Xylose Incorporated in Unsymmetrical Gold(I) N‐Heterocyclic Carbene Complexes: Synthesis, Characterization and Antibacterial Activity
Authors: Pascual Laura M. H. , Colin Marius , Mohamadou Aminou , Kowandy Christelle , Plantier‐Royon Richard , Gatard Sylvain 
Published: August 2024

AbstractA series of Au(I) complexes containing unsymmetrical N‐heterocyclic carbene (imidazolylidene and benzimidazolylidene) functionalized with a xyloside group and an alkyl moiety (methyl and mesityl) was prepared using efficient procedures from D‐xylose. Their characterization was carried out in solution by multinuclear NMR, HR‐MS spectrometry and cyclic voltammetry, as well as in the solid state by means of single crystal X‐ray diffraction analysis for two of them. Evaluation of their ability to inhibit bacterial growth showed a preference for a Gram‐positive strain, Staphylococcus aureus, over a Gram‐negative strain, Pseudomonas aeruginosa.
Synthetic Benzylic Diselenides and Disulfides: Potential Anticancer Activities via Modulation of the ROS‐Dependent Akt/β‐Catenin Signaling Pathway
Authors: Barman Pallavi , Misra Roopjyoti , Pal Nikita , Sarkar Shilpi , Bhabak Krishna P. 
Published: August 2024

AbstractThe natural and synthetic organodiselenides have garnered much research attention due to their chemotherapeutic and chemopreventive activities. Herein, we describe the synthesis of a series of benzylic diselenides, which were synthesized by coupling the in situ generated disodium diselenide with the corresponding benzylic halides. The diselenides were evaluated for their anticancer activities in the highly aggressive triple‐negative breast cancer cells. Preliminary anti‐proliferative activities indicated 4‐cyano‐substituted diselenide 7 to be most potent with an IC50 value of 1.9±0.3 μM. Detailed mechanistic investigations showed that diselenide 7 induces apoptosis and causes G1 phase arrest of the cell cycle. It exhibits anticancer activity by suppressing the Akt/β‐catenin signaling pathway. Further control experiments with LiCl (inhibitor of GSK‐3β) revealed that down‐regulation of β‐catenin was promoted by GSK‐3β‐induced phosphorylation of β‐catenin and its subsequent proteasomal degradation. Moreover, the intracellular ROS was found to act as an upstream mediator for the inactivation of the Akt/β‐catenin signaling pathway. The present study describing the efficient anticancer activity of a synthetic benzylic diselenide towards triple‐negative breast cancer cells through the modulation of ROS‐dependent Akt/β‐catenin signaling pathway would certainly be helpful in the future towards the development of small‐molecule organoselenium compounds for the treatment of cancer.
Design, Development of Pyrazole‐Linked Spirocyclopropyl Oxindole‐Carboxamides as Potential Cytotoxic Agents and Type III Allosteric VEGFR‐2 Inhibitors
Authors: Valapil Durgesh Gurukkala , Devabattula Geetanjali , Sakla Akash P. , Godugu Chandraiah , Shankaraiah Nagula 
Published: August 2024

AbstractTumor progression depends on angiogenesis, which is stimulated by growth factors like VEGF, targeting VEGFR kinase with small molecules is an effective anti‐angiogenic therapeutic approach. The rational modification of sunitinib (VEGFR‐2 inhibitor) to spirocyclopropyloxindoline carboxamides have been performed and their in vitro cytotoxic profiling was evaluated. The molecular modelling studies enabled the screening of designed analogues and identifying the possible interactions within the type III allosteric inhibitor binding site of VEGFR‐2. The biological screening of synthesized compounds 15 a–y, revealed the ability of compound 15 w to inhibit the cell growth in MCF‐7 cell line with IC50 value of 3.87±0.19 μM and alongside inhibition of VEGFR‐2 kinase at a IC50 concentration of 4.34±0.13 μM was observed. Also, VEGFR‐2 inhibition was validated through HUVEC tube formation inhibition assay. The qualitative assessment of apoptosis induction by 15 w in MCF‐7 cells was evaluated through staining studies such as AO/EB and DAPI staining, whereas quantification of apoptosis and cell cycle analysis were performed through FACS analysis. The metastatic ability of the cancer cells was evaluated through inhibition of cell migration by a scratch wound healing assay. The current study strives to sequentially optimize the structural attributes of the 3‐alkenyl oxindole core to surpass the existing challenges of well‐known VEGFR‐2 inhibitors. The findings observed from this study highlights that compound 15 w to be a prominent lead towards the development of clinical drug candidates.