bluuebunny/crossref_metadata_2025_split huggingface dataset:
BTRFS
Authors: Rodeh Ohad , Bacik Josef , Mason Chris 
Published: September 2013

BTRFS is a Linux filesystem that has been adopted as the default filesystem in some popular versions of Linux. It is based on copy-on-write, allowing for efficient snapshots and clones. It uses B-trees as its main on-disk data structure. The design goal is to work well for many use cases and workloads. To this end, much effort has been directed to maintaining even performance as the filesystem ages, rather than trying to support a particular narrow benchmark use-case.
Linux filesystems are installed on smartphones as well as enterprise servers. This entails challenges on many different fronts.

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Scalability
. The filesystem must scale in many dimensions: disk space, memory, and CPUs.

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Data integrity
. Losing data is not an option, and much effort is expended to safeguard the content. This includes checksums, metadata duplication, and RAID support built into the filesystem.

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Disk diversity
. The system should work well with SSDs and hard disks. It is also expected to be able to use an array of different sized disks, which poses challenges to the RAID and striping mechanisms.

This article describes the core ideas, data structures, and algorithms of this filesystem. It sheds light on the challenges posed by defragmentation in the presence of snapshots, and the tradeoffs required to maintain even performance in the face of a wide spectrum of workloads.
Integrin α3β1 Can Function to Promote Spontaneous Metastasis and Lung Colonization of Invasive Breast Carcinoma
Authors: Zhou Bo , Gibson-Corley Katherine N. , Herndon Mary E. , Sun Yihan , Gustafson-Wagner Elisabeth , Teoh-Fitzgerald Melissa , Domann Frederick E. , Henry Michael D. , Stipp Christopher S. 
Published: September 2013

Abstract
Significant evidence implicates α3β1 integrin in promoting breast cancer tumorigenesis and metastasis-associated cell behaviors in vitro and in vivo. However, the extent to which α3β1 is actually required for breast cancer metastasis remains to be determined. We used RNA interference to silence α3 integrin expression by approximately 70% in 4T1 murine mammary carcinoma cells, a model of aggressive, metastatic breast cancer. Loss of α3 integrin reduced adhesion, spreading, and proliferation on laminin isoforms, and modestly reduced the growth of orthotopically implanted cells. However, spontaneous metastasis to lung was strikingly curtailed. Experimental lung colonization after tail vein injection revealed a similar loss of metastatic capacity for the α3-silenced (α3si) cells, suggesting that critical, α3-dependent events at the metastatic site could account for much of α3β1′s contribution to metastasis in this model. Reexpressing α3 in the α3si cells reversed the loss of metastatic capacity, and silencing another target, the small GTPase RhoC, had no effect, supporting the specificity of the effect of silencing α3. Parental, α3si, and α3-rescued cells, all secreted abundant laminin α5 (LAMA5), an α3β1 integrin ligand, suggesting that loss of α3 integrin might disrupt an autocrine loop that could function to sustain metastatic growth. Analysis of human breast cancer cases revealed reduced survival in cases where α3 integrin and LAMA5 are both overexpressed.
Implications: α3 integrin or downstream effectors may be potential therapeutic targets in disseminated breast cancers, especially when laminin α5 or other α3 integrin ligands are also over-expressed. Mol Cancer Res; 12(1); 143–54. ©2013 AACR.
Frequency Analysis of Atrial Action Potential Alternans
Authors: Lalani Gautam G. , Schricker Amir A. , Clopton Paul , Krummen David E. , Narayan Sanjiv M. 
Published: September 2013

Background—
Few clinical indices identify the propensity of patients to atrial fibrillation (AF) when not in AF. Repolarization alternans has been shown to indicate AF vulnerability, but is limited in its sensitivity to detect changes in action potential (AP) duration (APD), which may be subtle. We hypothesized that spectral analysis would be a more sensitive and robust marker of AP alternans and thus a better clinical index of individual propensity to AF than APD alternans.

Methods and Results—

In 31 patients (12 persistent AF, 15 paroxysmal AF, 4 controls with no AF), we recorded left (n=27) and right (n=6) atrial monophasic APs during incremental pacing from cycle length 500 ms (120 beats per minute) to AF onset. Alternans was measured by APD and spectral analysis. At baseline pacing (median cycle length [1st, 3rd quartiles], 500 ms [500, 500]), APD alternans was detected in only 7 of 27 AF patients (no controls), whereas spectral AP alternans was detected in 18 of 27 AF patients (no controls;
P
=0.003); AP alternans was more prevalent in persistent than paroxysmal AF, and absent in controls (
P
=0.018 APD;
P
=0.042 spectral). Spectral AP alternans magnitude at baseline was highest in persistent AF, with modest rate-dependent amplification, followed by paroxysmal AF, with marked rate dependence, and undetectable in controls until just before induced AF.

Conclusions—
Spectral AP alternans near baseline rates can identify patients with, versus those without, clinical histories and pathophysiological substrates for AF. Future studies should examine whether the presence of spectral AP alternans during sinus rhythm may obviate the need to actually demonstrate AF, such as on ambulatory ECG monitoring.
Trapped Platelets Activated in Ischemia Initiate Ventricular Fibrillation
Authors: Dhanjal Tarvinder S. , Medina Rodolfo A. , Leem Jinwoo , Clark James E. , Southworth Richard , Curtis Michael J. 
Published: September 2013

Background—
We tested the hypothesis that ischemia-induced ventricular fibrillation (VF) is facilitated by platelets, trapped regionally in the ischemic zone and activated to release arrhythmogenic secretome.

Methods and Results—

In a randomized study in blood-free, buffer-perfused isolated rat hearts, ischemic zone territory (34±1% of left ventricle) was selected so that ischemia evoked VF in only 42% of controls. VF incidence was increased to 91% (
P
<0.05) by coronary ligation–induced trapping of freshly prepared autologous platelets (infused before and during coronary ligation, with trapping confirmed by
111
In-labeled platelet autoradiographic imaging). Trapping of platelet secretome prepared ex vivo, or platelet-sized fluorospheres, did not increase ischemia-induced VF incidence. Secretome alone did, however, evoke VF in 2 sham coronary-ligated hearts. Perfusion did not activate infused platelets in sham coronary-ligated hearts, whereas ligation activated trapped platelets (assessed by thromboxane release). In a separate study, trapping whole-heparinized blood mimicked the ability of trapped platelets to increase VF incidence. This effect was not prevented by >5 days oral pretreatment in vivo with clopidogrel (10 mg/kg per day) or indomethacin (2.4 mg/kg per day).

Conclusions—
Platelets facilitate VF during acute ischemia independently of their ability to participate in occlusive thrombosis. Moreover, the effect is unresponsive to antiplatelet drugs commonly used. Labile secretome constituents appear to be responsible. This opens a novel avenue for antiarrhythmic drug research.
Nonthermal Cardiac Catheter Ablation Using Photodynamic Therapy
Authors: Kimura Takehiro , Takatsuki Seiji , Miyoshi Shunichiro , Fukumoto Kotaro , Takahashi Mei , Ogawa Emiyu , Ito Arisa , Arai Tsunenori , Ogawa Satoshi , Fukuda Keiichi 
Published: September 2013

Background—
Radiofrequency ablation has limitations, largely related to creation of lesions by heating. Here, we report the first nonthermal ablation by applying photodynamic therapy (PDT) to cardiac tissues using a custom-made deflectable laser catheter. The present study investigated the feasibility of PDT for cavotricuspid isthmus ablation in a canine model.

Methods and Results—
We evaluated the pharmacokinetic profiles of 17 canines after administration of a photosensitizer (talaporfin sodium) by various protocols. We succeeded in maintaining the photosensitizer concentration at a level in excess of the clinically effective dose for humans. Using a 4-polar 7-French deflectable laser catheter, we performed PDT-mediated cavotricuspid isthmus ablation in 8 canines. PDT caused oxidative injury only to the irradiated area and successfully produced a persistent electric conduction block. No acute, gross changes such as edematous degeneration, thrombus formation, steam pops, or traumatic injury were observed after irradiation. Hematoxylin and eosin staining of tissues samples also showed well-preserved endothelial layers. Testing of the blood samples taken before and after the procedure revealed no remarkable changes. Lesion size at 2 weeks after the procedure and the temperature data collected during irradiation were compared between the PDT and irrigated radiofrequency ablation procedures. A ventricular cross-section revealed a solid PDT lesion, which was as deep as a radiofrequency lesion. In addition, endocardial, surficial, and intramural temperature monitoring during the PDT irradiation clearly demonstrated the nonthermal nature of the ablation technique.

Conclusions—
Nonthermal PDT-mediated catheter ablation is a potentially novel treatment for cardiac arrhythmias.
Thinking on Different Levels of Narrative Time: J.T. Fraser’s Eotemporal Hierarchical Theory and Samuel Beckett’s Prototemporal Cosmos
Authors: Harris Paul A. 
Published: September 2013

Abstract
This essay examines different modes of organizing narrative time and the thinking about time that narrative temporalities make possible. J.T. Fraser’s hierarchical theory of time is framed as a narrative which displays a conflict between subsuming time into form and depicting a natural history of time. Fraser’s work is characterized by an eotemporal narrative time that is able to range freely across a continuous, reversible temporal world. Fraser’s assessment of Samuel Beckett’s plays as depicting a prototemporal cosmos is summarized and then supplemented with reflections on how the prototemporal narrative time of Waiting for Godot enables thought to confront time, death and life in stark clarity.
The Time of Freedom
Authors: Schweidler Walter 
Published: September 2013

Abstract
The question of the beginning and end of time raises philosophical problems which lead into the core of J.T. Fraser’s thinking. In reference to some features of his work one can show the relevance of metaphysical ideas like the concept of an ontological plurality of times and especially the idea of an absolute past. This idea has been developed in systematic form by the German idealist thinker Schelling. Schelling speaks of a reality which is in itself neither temporal nor eternal but has limitations which only in relation to the time of our universe are turned into a temporal structure. In this view, which is also important for the understanding of current phenomenological positions (Lévinas, Marion), there is a second time, a “temps perdu,” which is equidistant from any new event in our universe including its possible beginning and end.
On the Limits of Time in the Brain
Authors: Lestienne Rémy 
Published: September 2013

Abstract
J.T. Fraser used to emphasize the uniqueness of the human brain in its capacity for apprehending the various dimensions of “nootemporality” (Fraser 1982 and 1987). Indeed, our brain allows us to sense the flow of time, to measure delays, to remember past events or to predict future outcomes. In these achievements, the human brain reveals itself far superior to its animal counterpart. Women and men are the only beings, I believe, who are able to think about what they will do the next day. This is because such a thought implies three intellectual abilities that are proper to mankind: the capacity to take their own thoughts as objects of their thinking, the ability of mental time travels—to the past thanks to their episodic memory or to the future—and the possibility to project very far into the future, as a consequence of their enlarged and complexified forebrain. But there are severe limits to our timing abilities of which we are often unaware. Our sensibility to the passing time, like other of our intellectual abilities, is often competing with other brain functions, because they use at least in part the same neural networks. This is particularly the case regarding attention. The deeper the level of attention required, the looser is our perception of the flow of time. When we pay attention to something, when we fix our attention, then our inner sense of the flux of time freezes. This limitation should not sound too unfamiliar to the reader of J.T. Fraser who wrote in his book Time, Conflict, and Human Values (1999) about “time as a nested hierarchy of unresolvable conflicts.”
Temporalities with a Human Face
Authors: Aultman Mark 
Published: September 2013

Abstract
J.T. Fraser’s writing added a measure of both scientific and humanistic seriousness to my somewhat unformed thoughts on the nature of society and social reality as a communication mechanism. His hierarchical theory of time lent weight to a worldview of time as an evolution in a direction toward something. This was despite his views, based on the necessities of irresolvable conflicts in the interstices between hierarchical levels, on sociotemporality as a kind of anthill threshold threatening individuality. His always welcoming personal approach to people and ideas served, if not as a contradiction, at least as a counterweight to the more disheartening implications of his theory. And his founding of the ISST, with its insistence on interdisciplinary communication, has served as an institutional counterweight.
Appreciating Conflict: Lessons from J.T. Fraser’s Theory of Time
Authors: Steineck Raji C. 
Published: September 2013

Abstract
Conflict is both a creative force in the establishment and a necessary condition for the sustenance of all higher modes of being. This, in short, I find to be one of the most ground-breaking insights of J. T. Fraser’s theory of “Time as a Hierarchy of Creative Conflicts.” As a consequence of this insight, I argue that to understand, with Fraser, the constitutive and creative function of some kinds of conflict will help us to accept, and even embrace, conflict not merely as a perpetual fact, as suggested by Stuart Hampshire, but as a necessary condition that makes possible whatever is of specific value in human culture. I go on to propose to distinguish between accidental and constitutive conflicts, and show how assessing conflicts accordingly can help to better manage them and avoid some destructive paths of action. The paper closes with some reflections on the limitations of the insight and its application.
<p class="HeadingRunIn" align="left">Australian Marsh Beetles (Coleoptera: Scirtidae) 4. Two new genera, Austrocyphon and Tasmanocyphon
Authors: ZWICK PETER 
Published: September 2013

The related new genera Austrocyphon and Tasmanocyphon are erected for 42 small Australian marsh beetles resembling members of the genus Cyphon Paykull in habitus. They are distinguished from Cyphon. Only males are known of most species but for two of them larvae and pupae are also available. Austrocyphon species occur in all Australian Federal States, and one species is Australasian and shared with Papua New Guinea. The following species are included: Austrocyphon acaciae sp. n., A. aculeatus sp. n., A. acustropicus sp. n., A. adelaidae (Blackburn), A. asper sp. n., A. bidens sp. n., A. bifidus sp. n., A. charon sp. n., A. crinitus (Klausnitzer), A. curvispina, sp. n., A. deserticola sp. n., A. doctus (Lea), A. enigmaticus sp. n., A. excisus sp. n., A. fenestratus (Blackburn), A. flagellifer sp. n., A. furcatus sp. n., A. hamatus sp. n., A. harpago sp. n., A. leptophallus sp. n., A. linguatus sp. n., A. lobatus sp. n., A. neptunus sp. n., A. noctua sp. n., A. ovensensis (Blackburn), A. papilio sp. n., A. perdoctus sp. n., A. pictus (Blackburn), A. quadridens sp. n., A. quinquespinosus sp. n., A. robustus sp. n., A. setifer sp. n., A. spiculifer sp. n., A. stylatus sp. n., A. stylifer sp. n., A. submersus sp. n., A. tinea sp. n., A. tomweiri sp. n., A. tribulator sp. n., A. tropicus sp. n., A. unguiculatus sp. n., A. wattsi sp. n. Tasmanocyphon is endemic to Tasmania, and only the adult male is known. The genus is monotypic, including only T. heideae, sp. n.
<p class="HeadingRunIn" align="left">Cradoscrupocellaria, a new bryozoan genus for Scrupocellaria bertholletii (Audouin) and related species (Cheilostomata, Candidae): taxonomy, biodiversity and distribution
Authors: VIEIRA LEANDRO M. , JONES MARY E. SPENCER , WINSTON JUDITH E. 
Published: September 2013

A new genus, Cradoscrupocellaria n. gen., is erected for Scrupocellaria bertholletii (Audouin, 1826), reported as widespread in tropical and subtropical waters. Here we select a neotype of this species in order to establish its identity and distinguish it from morphologically similar species. We include redescriptions and figures of additional species now assigned to this new genus: Cradoscrupocellaria curacaoensis (Fransen, 1986) n. comb., Cradoscrupocellaria hirsuta (Jullien & Calvet, 1903) n. comb., and Cradoscrupocellaria macrorhyncha (Gautier, 1962) n. comb. Five additional species are assigned to the genus: Cradoscrupocellaria ellisi (Vieira & Spencer Jones, 2012) n. comb., Cradoscrupocellaria nanshaensis (Liu, 1991) n. comb., Cradoscrupocellaria reptans (Linnaeus, 1758) n. comb., Cradoscrupocellaria serrata (Waters, 1909) n. comb., and Cradoscrupocellaria tenuirostris (Osburn, 1950) n. comb. Eighteen new species are described: Cradoscrupocellaria aegyptiana n. sp., Cradoscrupocellaria arisaigensis n. sp., Cradoscrupocellaria atlantica n. sp., Cradoscrupocellaria calypso n. sp., Cradoscrupocellaria floridana n. sp., Cradoscrupocellaria galapagensis n. sp., Cradoscrupocellaria gautieri n. sp., Cradoscrupocellaria gorgonensis n. sp., Cradoscrupocellaria hastingsae n. sp., Cradoscrupocellaria insularis n. sp., Cradoscrupocellaria jamaicensis n. sp., Cradoscrupocellaria lagaaiji n. sp., Cradoscrupocellaria macrorhynchoides n. sp., Cradoscrupocellaria makua n. sp., Cradoscrupocellaria marcusorum n. sp., Cradoscrupocellaria normani n. sp., Cradoscrupocellaria odonoghuei n. sp., and Cradoscrupocellaria osburni n. sp.
Drake Passage Oceanic pCO2: Evaluating CMIP5 Coupled Carbon–Climate Models Using in situ Observations
Authors: Jiang ChuanLi , Gille Sarah T. , Sprintall Janet , Sweeney Colm 
Published: September 2013

AbstractSurface water partial pressure of CO2 (pCO2) variations in Drake Passage are examined using decade-long underway shipboard measurements. North of the Polar Front (PF), the observed pCO2 shows a seasonal cycle that peaks annually in August and dissolved inorganic carbon (DIC)–forced variations are significant. Just south of the PF, pCO2 shows a small seasonal cycle that peaks annually in February, reflecting the opposing effects of changes in SST and DIC in the surface waters. At the PF, the wintertime pCO2 is nearly in equilibrium with the atmosphere, leading to a small sea-to-air CO2 flux.These observations are used to evaluate eight available Coupled Model Intercomparison Project, phase 5 (CMIP5), Earth system models (ESMs). Six ESMs reproduce the observed annual-mean pCO2 values averaged over the Drake Passage region. However, the model amplitude of the pCO2 seasonal cycle exceeds the observed amplitude of the pCO2 seasonal cycle because of the model biases in SST and surface DIC. North of the PF, deep winter mixed layers play a larger role in pCO2 variations in the models than they do in observations. Four ESMs show elevated wintertime pCO2 near the PF, causing a significant sea-to-air CO2 flux. Wintertime winds in these models are generally stronger than the satellite-derived winds. This not only magnifies the sea-to-air CO2 flux but also upwells DIC-rich water to the surface and drives strong equatorward Ekman currents. These strong model currents likely advect the upwelled DIC farther equatorward, as strong stratification in the models precludes subduction below the mixed layer.
The influence of lumbar spinal drainage on diffusion parameters in patients with suspected normal pressure hydrocephalus using 3T MRI
Authors: Reiss-Zimmermann Martin , Scheel Michael , Dengl Markus , Preuß Matthias , Fritzsch Dominik , Hoffmann Karl-Titus 
Published: September 2013

Background Normal pressure hydrocephalus (NPH) has been an ongoing and challenging field of research for the past decades because two main issues are still not fully understood: the pathophysiologic mechanisms underlying ventricular enlargement and prediction of outcome after surgery. Purpose To evaluate changes in diffusion tensor imaging (DTI) derived parameters in patients with suspected normal pressure hydrocephalus before and after withdrawal of cerebrospinal fluid (CSF). Material and Methods Twenty-four consecutive patients with clinical and radiological suspicion of NPH and 14 age-matched control subjects were examined with DTI on a clinical 3T scanner. Patients were examined before and 6–36 h after CSF drainage (interval between scans, 5 days). Fifteen patients were finally included in data analysis. Fractional anisotropy (FA) and mean, parallel, and radial diffusivity (MD, PD, RD) were evaluated using a combination of a ROI-based approach and a whole-brain voxel-by-voxel analysis. Results Alteration of DTI parameters in patients with suspected NPH is regionally different. Compared to the control group, we found an elevation of FA in the subcortical white matter (SCWM) and corpus callosum, whereas the other diffusion parameters showed an increase throughout the brain in variable extent. We also found a slight normalization of RD in the SCWM in patients after lumbar drainage. Conclusion Our results show that DWI parameters are regionally dependent and reflect multifactorial (patho-) physiological mechanisms, which need to be interpreted carefully. It seems that improvement of gait is caused by a decrease of interstitial water deposition in the SCWM.
The comparative efficacy of intramuscular antipsychotics for the management of acute agitation
Authors: Bosanac Peter , Hollander Yitzchak , Castle David 
Published: September 2013

Objective: To review the current role and comparative efficacy of short-acting intramuscular (IM) antipsychotics in the management of acute agitation, in current clinical practice. Method: The efficacy and tolerability of IM antipsychotics in the management of acute agitation in current clinical practice were reviewed in the Medline, PubMed, Cinahl Plus, Scopus-v.4 and PsycInfo databases. Results: The comparative efficacy of the rapidly-acting IM atypical antipsychotics (olanzapine, ziprasidone and aripiprazole) is similar to that of the typical antipsychotic, haloperidol. IM olanzapine and ziprasidone were associated with fewer extrapyramidal side-effects and had similar cardiac tolerability to IM haloperidol. Conclusions: Further studies are required in the ongoing development of contemporary, evidence-based clinical guidelines in acute agitation, including head-to-head comparisons of currently utilized IM atypical antipsychotics, sequential treatment or combinations of medications.