bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyaluronic acid-modified liposomes Potentiated in-vivo anti-hepatocellular carcinoma of icaritin
Authors: Sun Xiaoduan , He Zhenzhen , Lu Ruilin , Liu Zhongbing , Chiampanichayakul Sawitree , Anuchapreeda Songyot , Jiang Jun , Tima Singkome , Zhong Zhirong 
Published: July 2024

Introduction: Icaritin (ICT), a promising anti-hepatocellular carcinoma (HCC) prenylated flavonoid, is hindered from being applied due to its low water solubility and high lipophilicity in poorly differentiated HCC which is associated with upregulation of CD44 isoforms. Thus, hyaluronic acid (HA), a natural polysaccharide with high binding ability to CD44 receptors, was used to formulate a modified liposome as a novel targeted ICT-delivery system for HCC treatment.Methods: The ICT-Liposomes (Lip-ICT) with and without HA were prepared by a combined method of thin-film dispersion and post-insertion. The particle size, polydispersity (PDI), zeta potential, encapsulation efficacy (%EE), drug loading content (%DLC), and in vitro drug release profiles were investigated for physicochemical properties, whereas MTT assay was used to assess cytotoxic effects on HCC cells, HepG2, and Huh7 cells. Tumor bearing nude mice were used to evaluate the inhibitory effect of HA-Lip-ICT and Lip-ICT in vivo.Results: Lip-ICT and HA-Lip-ICT had an average particle size of 171.2 ± 1.2 nm and 208.0 ± 3.2 nm, with a zeta potential of −13.9 ± 0.83 and −24.8 ± 0.36, respectively. The PDI resulted from Lip-ICT and HA-Lip-ICT was 0.28 ± 0.02 and 0.26 ± 0.02, respectively. HA-Lip-ICT demonstrated higher in vitro drug release when pH was dropped from 7.4 to 5.5, The 12-h release rate of ICT from liposomes increased from 30% at pH7.4 to more than 60% at pH5.5. HA-Lip-ICT displayed higher toxicity than Lip-ICT in both HCC cells, especially Huh7with an IC50 of 34.15 ± 2.11 μM. The in vivo tissue distribution and anti-tumor experiments carried on tumor bearing nude mice indicated that HA-Lip- ICT exhibited higher tumor accumulation and achieved a tumor growth inhibition rate of 63.4%.Discussion: The nano-sized Lip-ICT was able to prolong the drug release time and showed long-term killing HCC cells ability. Following conjugation with HA, HA-Lip-ICT exhibited higher cytotoxicity, stronger tumor targeting, and tumor suppression abilities than Lip-ICT attributed to HA-CD44 ligand-receptor interaction, increasing the potential of ICT to treat HCC.
Protective effect of naringenin on cadmium chloride-induced renal injury via alleviating oxidative stress, endoplasmic reticulum stress, and autophagy in chickens
Authors: Shi Yaning , Gao Zhixin , Xu Bing , Mao Junbing , Wang Yue , Liu Zongping , Wang Jicang 
Published: July 2024

Cadmium (Cd) is a highly hazardous toxic substance that can cause serious harm to animals. Previous studies have indicated that cadmium chloride (CdCl2) can damage organs, such as the liver, ovaries, and testicles. Naringenin (Nar) represents a flavonoid with various properties that promote the alleviation of Cd-induced damage. In this experiment, 60 chickens were divided into the control group, 150 mg/kg CdCl2 treatment group, 250 mg/kg Nar treatment group, and 150 mg/kg CdCl2 + 250 mg/kg Nar co-treatment group, which were treated for 8 weeks. Kidney tissues samples were collected to investigate kidney function, including oxidative stress (OS), endoplasmic reticulum (ER) stress, and autophagy activity. Experimental results showed the decreased weight of chickens and increased relative weight of their kidneys after CdCl2 treatment. The increase in NAG, BUN, Cr, and UA activities, as well as the increase in MDA and GSH contents, and the decrease activities of T-AOC, SOD, and CAT in the kidney, manifested renal injury by OS in the chickens. TUNEL staining revealed that CdCl2 induced apoptosis in renal cells. CdCl2 upregulates the mRNA and protein expression levels of GRP78, PERK, eIF2α, ATF4, ATF6, CHOP, and LC3, and inhibited the mRNA and protein expression levels of P62 proteins, which leads to ER stress and autophagy. The CdCl2 + Nar co-treatment group exhibited alleviated CdCl2-induced kidney injury, OS, ER stress, and autophagy. Research has demonstrated that Nar reduces CdCl2-induced kidney injury through alleviation of OS, ER stress, and autophagy.
When “I” or “S/He” uses the product: the impact of narrative perspective on consumers’ brand attitudes in storytelling ads
Authors: Chen Tingting , Fan Xinqiao , He Jiayu , Fan Jun , Chen Wei 
Published: July 2024

IntroductionStorytelling ad is presented from one or more narrative perspectives. Narrative perspective, which can alter the way in which the plot is physiologically or psychologically perceived, can significantly affect consumer experience.MethodsThis study conducts three experiments with 526 participants to analyze the influencing mechanism of narrative perspective (first- versus third-person) on consumers’ brand attitudes in storytelling ads of products with different involvement (high versus low).Results(a) Narrative perspective (first- versus third-person) exerts persuasive effects on consumer brand attitudes; (b) Processes of social presence and self-brand connection explain the effects of narrative perspective on brand attitudes; (c) When product involvement is high, the use of the first-person narrative perspective in storytelling ads will result in a more positive brand attitude than the use of third-person narrative will; With lower product involvement, there is no significant difference in the impact on brand attitudes regardless of narrative perspective (first-person versus third-person).DiscussionThis research finds that different narrative perspectives significantly impact the persuasiveness of advertising. Boundary conditions exist for the effect of narrative persuasion, and product involvement moderates the effect of narrative perspective on brand attitudes.
Exploring the meaning of life among Chinese adolescents with nephrotic syndrome: determinants and psychological correlates
Authors: Liang Ying , Huang Ruijie , Luo Xiuzhuang , Mo Shuyan , He Zhichuan , Tian Junhong , Yang Lijuan , Xue Yi , Luo Xiaomi 
Published: July 2024

BackgroundAdolescents with Nephrotic Syndrome (NS) confront unique challenges that influence their Meaning of Life (MOL), a concept crucial for psychological resilience. The chronic nature of NS and its associated burdens necessitate a deeper exploration of MOL and its determinants within this demographic, previously underexamined in research. This study aims to investigate MOL among Chinese adolescents with NS, identifying key factors influencing their sense of meaning and examining the interrelations with Subjective Well-Being (SWB) and Psychological Security (PS).MethodsEmploying a cross-sectional survey design, we analyzed 150 adolescents with NS from Baise City, Guangxi, using the Purpose in Life (PIL) scale alongside PS and SWB scales. Sociodemographic and disease-related variables were assessed for their impact on MOL. Data analysis included descriptive statistics, multiple linear regression, and correlation analyses to explore predictors of MOL and its association with SWB and PS.ResultsA significant proportion (62.0%) of participants exhibited MOL scores below the threshold, indicating diminished life meaning. Critical factors impacting MOL included ‘left-behind’ status, family structure, educational disruptions, and NS duration. Strong correlations emerged between MOL, SWB (r = 0.70, p &lt; 0.01), and PS, highlighting the interdependence of these psychological dimensions. The study further revealed ‘Proactivity’ as a vital component of MOL, suggesting that despite their challenges, adolescents with NS maintain a keen engagement with life. Key aspects such as ‘Certainty in Control’, ‘Mood of Melancholy or Pleasure’, and ‘Vitality’ emerged as crucial for intervention.ConclusionThe findings underline the profound impact of NS on adolescents’ MOL, influenced by both sociodemographic and disease-specific factors. By identifying key areas for psychological intervention, this study contributes to the holistic care and treatment of adolescents with NS, advocating for integrated approaches that address their unique challenges and support systems.
How are poor sleepers with other clinical conditions affected by maladaptive personality traits? A neural network-based analysis
Authors: Khazaie Habibolah , Rezaei Farzin , Zakiei Ali , Faridmarandi Behrooz , Komasi Saeid 
Published: July 2024

BackgroundPsychopathology research mainly focused on the cross-sectional and longitudinal associations between personality and psychiatric disorders without considering the moment-to-moment dynamics of personality in response to environmental situations. The present study aimed to both cluster a young sample according to three mixed clinical conditions (poor sleep quality, depression, and somatization) and to predict the derived clusters by maladaptive personality traits and sex differences using a deep machine learning approach.MethodsA sample of 839 adults aged 18-40 years (64% female) from the west of Iran were clustered according to the mixed clinical conditions using the cluster analysis techniques. An Artificial Neural Network (ANN) modeling is used to predict the derived clusters by maladaptive personality traits and biological gender. A receiver operating characteristic (ROC) curve was used to identify independent variables with high sensitivity specific to the derived clusters.ResultsThe cluster analysis techniques suggested a fully stable and acceptable four-cluster solution for Depressed Poor Sleepers, Nonclinical Good Sleepers, Subclinical Poor Sleepers, and Clinical Poor Sleepers. The ANN model led to the identification of one hidden layer with two hidden units. The results of Area under the ROC Curve were relatively to completely acceptable, ranging from.726 to.855. Anhedonia, perceptual dysregulation, depressivity, anxiousness, and unusual beliefs are the most valuable traits with importance higher than 70%.ConclusionThe machine learning approach can be well used to predict mixed clinical conditions by maladaptive personality traits. Future research can test the complexity of normal personality traits connected to mixed clinical conditions.
The impact of digital economy development on public health: evidence from Chinese cities
Authors: Li Hao , Li Yu 
Published: July 2024

IntroductionThe swift advancement of the digital economy not only plays a crucial role in stimulating a country’s economic growth but also exerts a significant influence on national health and well-being.MethodsAdopts the data of 285 prefecture-level cities in China from 2010 to 2022, and employs the panel data fixed-effects model, spatial Durbin model, and mediated effects model to study the impact of digital economic development on the level of urban public health.ResultsIt is found that digital economic development significantly improves the level of urban public health, and the effect has a spatial spillover effect. The impact of digital economic development on urban public health is mainly concentrated in cities with higher levels of economic development, higher levels of digital economic development, and lower levels of urban public health. Among them, technological innovation and information dissemination are the main dissemination channels through which digital economic development affects the level of urban public health.DiscussionThe advancement of the digital economy significantly impacts urban public health. It is advisable to bolster policies guiding digital economy development, enhance cross-sector collaboration between the digital economy and public health, reinforce public health education and awareness campaigns, improve the digital health literacy of the population, continue to enhance the fairness and accessibility of basic medical services, and address and bridge the “digital divide” between regions, as well as urban and rural areas.
Resonant breathing improves self-reported symptoms and wellbeing in people with Long COVID
Authors: Polizzi Jessica , Tosto-Mancuso Jenna , Tabacof Laura , Wood Jamie , Putrino David 
Published: July 2024

IntroductionLong COVID involves debilitating symptoms, many of which mirror those observed with dysautonomia, and care must be taken with rehabilitation for autonomic dysfunction to avoid post-exertional malaise/post-exertional symptom exacerbation. Resonant breathing (breathing slowly at a defined rate of breaths per minute) requires less exertion and can potentially improve autonomic function. The objective of this work was to report on the impact of a resonant breathing program on self-reported symptoms and wellbeing in people with Long COVID.MethodsA retrospective analysis of de-identified data was completed in a convenience sample of people with Long COVID, who participated in the Meo Health (formerly known as Stasis HP) resonant breathing program. Participants completed baseline and follow up surveys.ResultsData were available for 99 participants. Most measures of symptoms and wellbeing improved at follow up, with the largest differences per participant seen in sense of wellness (47.3%, p &lt; 0.0001), ability to focus (57.5%, p &lt; 0.0001), ability to breathe (47.5%, p &lt; 0.0001), ability to control stress (61.8%, p &lt; 0.0001) and sleep quality (34.9%, p = 0.0002). Most (92%) participants reported improvement at follow up on the Patient Global Impression of Change Scale.ConclusionSelf-reported symptoms and wellbeing improved in people with Long COVID completing resonant breathing. Resonant breathing can be considered as an option within the broader treatment plan of people with Long COVID.
Comparative subcutaneous and submuscular implantation of an electroencephalography device for long term electroencephalographic monitoring in dogs
Authors: Rogers Casey B. , Meller Sebastian , Meyerhoff Nina , Volk Holger A. 
Published: July 2024

BackgroundImplantable electroencephalography (EEG) recording devices have been used for ultra-long-term epilepsy monitoring both in clinical and home settings in people. Objective and accurate seizure detection and recording at home could be of great benefit in diagnosis, management and research in canine idiopathic epilepsy (IE). Continuous EEG monitoring would allow accurate detection of seizure patterns, seizure cycles, and seizure frequency. An EEG acquisition system usable in an “out of clinic” setting could improve owner and veterinary compliance for EEG diagnostics and seizure management.ObjectivesWhether a subcutaneous ultra-long term EEG monitoring device designed for humans could be implanted in dogs.AnimalsCadaver study with 8 medium to large breed dogs.MethodsComparatively using a subcutaneous and submuscular approach to implant the UNEEG SubQ-Implant in each dog. Positioning was controlled via CT post implantation and cranial measurements were taken.ResultsIn four of the eight dogs a submuscular implantation without any complications was possible. Complications were close contact to the optic nerve in the first approaches, before the implantation angle was changed and in the smallest dog contact of the implant with the orbital fat body. Cranial measurements of less than 95 mm length proved to be too small for reliable implantation via this approach. The subcutaneous approach showed severe limitations and the implant was prone to dislocation.ConclusionThe UNEEQ SubQ-Implant can be implanted in dogs, via submuscular approach. CT imaging and cranial measurements should be taken prior to implantation.
Computational Investigation of the Fluidic Properties of Triply Periodic Minimal Surface (TPMS) Structures in Tissue Engineering
Authors: Shahid Muhammad Noman , Shahid Muhammad Usman , Rasheed Shummaila , Irfan Muhammad , Obeidi Muhannad Ahmed 
Published: July 2024

Tissue engineering, a rapidly advancing field in medicine, has made significant strides with the development of artificial tissue substitutes to meet the growing need for organ transplants. Three-dimensional (3D) porous scaffolds are widely utilized in tissue engineering, especially in orthopedic surgery. This study investigated the fluidic properties of diamond and gyroid structures with varying porosity levels (50–80%) using Computational Fluid Dynamics (CFD) analysis. The pressure and velocity distributions were analyzed, and it was observed that the pressure decreased gradually, whereas the velocity increased in the central area of the surface structures. Specifically, the pressure drop ranged from 2.079 to 0.984 Pa for the diamond structure and from 1.669 to 0.943 Pa for the gyroid structure as the porosity increased from 50% to 80%. It was also found that the permeability increased as the porosity level increased, with values ranging from 2.424×10−9 to 5.122×10−9 m2 for the diamond structure and from 2.966×10−9 to 5.344×10−9 m2 for the gyroid structure. The wall shear stress (WSS) was also analyzed, showing a consistent decrease with increased porosity for both types of structures, with WSS values ranging from 9.903×10−2 to 9.840×10−1 Pa for the diamond structure and from 1.150×10−1 to 7.717×10−2 Pa for the gyroid structure. Overall, this study provides insights into the fluidic properties of diamond and gyroid structures, which can be useful in various applications such as tissue engineering.
Interval Type-2 Fuzzy Logic Control of Linear Stages in Feedback-Error-Learning Structure Using Laser Interferometer
Authors: Khanesar Mojtaba A. , Yan Minrui , Karaca Aslihan , Isa Mohammed , Piano Samanta , Branson David 
Published: July 2024

The output processer of interval type-2 fuzzy logic systems (IT2FLSs) is a complex operator which performs type-reduction plus defuzzification (TR+D) tasks. In this paper, a complexity-reduced yet high-performance TR+D for IT2FLSs based on Maclaurin series approximation is utilized within a feedback-error-learning (FEL) control structure for controlling linear move stages. IT2FLSs are widely used for control purposes, as they provide extra degrees of freedom to increase control accuracies. FEL benefits from a classical controller, which is responsible for providing overall system stability, as well as a guideline for the training mechanism for IT2FLSs. The Kalman filter approach is utilized to tune IT2FLS parameters in this FEL structure. The proposed control method is applied to a linear stage in real time. Using an identification process, a model of the real-time linear stage is developed. Simulation results indicate that the proposed FEL approach using the Kalman filter as an estimator is an effective approach that outperforms the gradient descent-based FEL method and the proportional derivative (PD) classical controller. Motivated by the performance of the proposed Kalman filter-based FEL approach, it is used to control a linear move stage in real time. The position feedback of the move stage is provided by a precision laser interferometer capable of performing measurements with an accuracy of less than 1 μm. Using this measurement system in a feedback loop with the proposed control algorithm, the overall steady state of the system is less than 20 μm. The results illustrate the high-precision control capability of the proposed controller in real-time.
Analysis of the Behavior of Deep Eutectic Solvents upon Addition of Water: Its Effects over a Catalytic Reaction
Authors: Campodónico Paola R. , Alarcón-Espósito Jazmín , Alcázar Jackson J. , Olivares Belén , Suárez-Rozas Cristian 
Published: July 2024

This study presents the potential role of deep eutectic solvents (DESs) in a lipase-catalyzed hydrolysis reaction as a co-solvent in an aqueous solution given by a phosphate buffer. Ammonium salts, such as choline chloride, were paired with hydrogen bond donors, such as urea, 1,2,3-propanetriol, and 1,2 propanediol. The hydrolysis of p-nitrophenyl laureate was carried out with the lipase Candida antarctica Lipase B (CALB) as a reaction model to evaluate the solvent effect and tested in different DES/buffer phosphate mixtures at different % w/w. The results showed that two mixtures of different DES at 25 % w/w were the most promising solvents, as this percentage enhanced the activities of CALB, as evidenced by its higher catalytic efficiency (kcatKM). The solvent analysis shows that the enzymatic reaction requires a reaction media rich in water molecules to enable hydrogen-bond formation from the reaction media toward the enzymatic reaction, suggesting a better interaction between the substrate and the enzyme-active site. This interaction could be attributed to high degrees of freedom influencing the enzyme conformation given by the reaction media, suggesting that CALB acquires a more restrictive structure in the presence of DES or the stabilized network given by the hydrogen bond from water molecules in the mixture improves the enzymatic activity, conferring conformational stability by solvent effects. This study offers a promising approach for applications and further perspectives on genuinely green industrial solvents.
Bubble Dynamics in the Polyakov Quark-Meson Model
Authors: Wang Junrong , Jin Jinshuang , Mao Hong 
Published: July 2024

In the framework of the Polyakov quark-meson model with two flavors, the bubble dynamics of a first-order phase transition in the region of high density and low temperature are investigated by using the homogeneous thermal nucleation theory. In mean-field approximation, after obtaining the effective potential with the inclusion of the fermionic vacuum term, we build a geometric method to search two existing minima, which can be actually connected by a bounce interpolated between a local minimum to an adjacent global one. For both weak and strong first-order hadron quark phase transitions, as fixing the chemical potentials at μ=306MeV and μ=310MeV, the bubble profiles, the surface tension, the typical radius of the bounce, and the saddle-point action as a function of temperature are numerically calculated in the presence of a nucleation bubble. It is found that the surface tension remains at a very small value even when the density is high. It is also noticed that the deconfinement phase transition does not change the chiral phase transition dramatically for light quarks and phase boundaries for hadron and quark matter should be resized properly according to the saddle-point action evaluated on the bounce solution.