bluuebunny/crossref_metadata_2025_split huggingface dataset:
1D Silver Nanowires/2D Graphene Composite Flexible Transparent Electrodes Induced by Superwetting Transfer
Authors: Zhao Xuanting , Zhang Yuqiang , Chen Xingchao , Ma Chuao , Liu Chan , Liu Hongliang , Diao Shen 
Published: August 2024

AbstractSilver nanowires (AgNWs) are promising materials for the fabrication of high‐performance flexible transparent electrodes (FTEs) due to their excellent optoelectronic properties, mechanical flexibility, and low‐cost solution processability. However, one serious obstacle that hinders the application of AgNWs‐based electrodes is the high contact resistance between AgNWs. Established methods for reducing contact resistance such as light‐induced welding, heat‐induced welding, and chemical welding require complex post‐treatment of the prepared AgNWs electrodes. Herein, a fully solution‐processable strategy is reported based on superwetting‐induced transfer for the preparation of composite FTEs electrodes without additional complex post‐process. The generated composite electrode is composed of 1D AgNWs as the percolation network and 2D graphene nanosheets as the conductivity‐enhanced component, significantly reducing the sheet resistance of the AgNWs film from 80.6 to 27.1 Ω·sq−1 while maintaining optical transmittance as high as 89.0%. The composite electrodes also exhibit superior mechanical bending stability and chemical stability. The composite electrodes are successfully applied to transparent heating devices, which show favorable thermal stability and heating effect. This study provides a new manner for the preparation of high‐performance FTEs, which can be compatible with large‐area and continuous production.
Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism
Authors: Schauer Stephen P. , Cho Chang Hoon , Novikova Gloriia , Roth Gillie A. , Lee Julie , Sharma Anup D. , Foley Alejandro R. , Ng Carl , Shen Philip , Choi Meena , Ma Taylur P. , Phu Lilian , Budayeva Hanna G. , Cheung Tommy K. , Lalehzadeh Guita , Imperio Jose , Ngu Hai , Etxeberria Ainhoa , Liang Yuxin , Rezzonico Mitchell G. , Dourado Michelle , Huang Kevin , Lai Zijuan , Hokom Martha , Pandya Nikhil J. , Newton Dwight , Abdel‐Haleem Alyaa M. , Chan Pamela , Lee Donna , Tassew Nardos G. , Sangaraju Dewakar , O'Connor Deborah , Hötzel Isidro , Stark Kimberly L. , Chou Carolina , Foreman Oded , Easton Amy , Wildsmith Kristin R. , Sperinde Gizette , Rose Christopher M. , Friedman Brad A. , Fuji Reina N. , Weimer Robby M. , Meilandt William J. , Sadekar Shraddha , Nugent Alicia A. , Biever Anne 
Published: August 2024

AbstractINTRODUCTIONTriggering receptor expressed on myeloid cells 2 (TREM2) agonists are being clinically evaluated as disease‐modifying therapeutics for Alzheimer's disease. Clinically translatable pharmacodynamic (PD) biomarkers are needed to confirm drug activity and select the appropriate therapeutic dose in clinical trials.METHODSWe conducted multi‐omic analyses on paired non‐human primate brain and cerebrospinal fluid (CSF), and stimulation of human induced pluripotent stem cell–derived microglia cultures after TREM2 agonist treatment, followed by validation of candidate fluid PD biomarkers using immunoassays. We immunostained microglia to characterize proliferation and clustering.RESULTSWe report CSF soluble TREM2 (sTREM2) and CSF chitinase‐3‐like protein 1 (CHI3L1/YKL‐40) as PD biomarkers for the TREM2 agonist hPara.09. The respective reduction of sTREM2 and elevation of CHI3L1 in brain and CSF after TREM2 agonist treatment correlated with transient microglia proliferation and clustering.DISCUSSIONCSF CHI3L1 and sTREM2 reflect microglial TREM2 agonism and can be used as clinical PD biomarkers to monitor TREM2 activity in the brain.Highlights
CSF soluble triggering receptor expressed on myeloid cells 2 (sTREM2) reflects brain target engagement for a novel TREM2 agonist, hPara.09.
CSF chitinase‐3‐like protein 1 reflects microglial TREM2 agonism.
Both can be used as clinical fluid biomarkers to monitor TREM2 activity in brain.
Actomyosin forces in cell migration: Moving beyond cell body retraction
Authors: Weißenbruch Kai , Mayor Roberto 
Published: August 2024

AbstractIn textbook illustrations of migrating cells, actomyosin contractility is typically depicted as the contraction force necessary for cell body retraction. This dogma has been transformed by the molecular clutch model, which acknowledges that actomyosin traction forces also generate and transmit biomechanical signals at the leading edge, enabling cells to sense and shape their migratory path in mechanically complex environments. To fulfill these complementary functions, the actomyosin system assembles a gradient of contractile energy along the front‐rear axis of migratory cells. Here, we highlight the hierarchic assembly and self‐regulatory network structure of the actomyosin system and explain how the kinetics of different nonmuscle myosin II (NM II) paralogs synergize during contractile force generation. Our aim is to emphasize how protrusion formation, cell adhesion, contraction, and retraction are spatiotemporally integrated during different modes of migration, including chemotaxis and durotaxis. Finally, we hypothesize how different NM II paralogs might tune aspects of migration in vivo, highlighting future research directions.
Luminous blue carbon quantum dots employing Anisomeles indica (catmint) induce apoptotic signaling pathway in triple negative breast cancer (TNBC) cells
Authors: Kumar Ponnuchamy , Mahalakshmi Marimuthu , Anitha Selvaraj , Durgadevi Sabapathi , Govarthanan Muthusamy 
Published: August 2024

AbstractHerein, luminous blue carbon quantum dots (CDs) employing Anisomeles indica (Catmint) were reported with imaging, self‐targeting, and therapeutic effects on triple‐negative breast cancer (TNBC, MDA‐MB‐231) cells. The salient features of CDs generated from catmint are as follows: i) optical studies confirm CDs with excitation‐dependent emission; ii) high‐throughput characterization authenticates the formation of CDs with near‐spherical shape with diameter ranging between 5 and 15 nm; iii) CDs induce cytotoxicity (3.22 ± 0.64 μg/ml) in triple‐negative breast cancer (TNBC, MDA‐MB‐231) cells; iv) fluorescence microscopy demonstrates that CDs promote apoptosis by increasing reactive oxygen species (ROS) and decreasing mitochondrial membrane potential; v) CDs significantly up‐regulate pro‐apoptotic gene expression levels such as caspases‐8/9/3. Finally, our work demonstrates that catmint‐derived CDs are prospective nanotheranostics that augment cancer targeting and imaging.
Retinoids Molecular Probes by Late‐stage Azide Insertion – Functional Tools to Decrypt Retinoid Metabolism
Authors: Coulleray Jessica , Kindler Alexia , Rima Mohamad , Cahuzac Héloïse , Rochel Natacha , Chaubet Guilhem , Krezel Wojciech , Wagner Alain 
Published: August 2024

AbstractStudying the complex and intricate retinoids metabolic pathways by chemical biology approaches requires design and synthesis of biologically functional molecular probes. Only few of such molecular retinoid probes could be found in literature, most of them bearing a molecular structure quite different from natural retinoids. To provide close‐to‐native retinoid probes, we have developed a versatile late‐stage method for the insertion of azide function at the C4 position of several retinoids. This one‐step process opens straightforward access to different retinoid and carotenoid probes from commercially available precursors. We have further demonstrated that the different molecular probes retain ability of the original compound to activate genes’ transcription, despite azide insertion, highlighting biological activities that were further validated in zebrafish in vivo model. The present work paves the way to future studies on vitamin A's metabolism.
A new design of double predictive proportional integral control strategy for first order plus dead time industrial processes
Authors: Hu Chonggao , Hou Yuqiao , Bai Jianjun , Zou Hongbo 
Published: August 2024

AbstractWhen the Smith predictive controller controls the first‐order plus dead time process, it is too sensitive to the parameter changes of the system, leading to poor system stability and no practical application value. First, this paper derives and proves the equivalent form of the Smith‐proportional‐integral‐derivative (PID) control strategy as a predictive PI (PPI) control strategy. Second, this paper proposes a new double predictive PI control strategy (DPPI), where the DPPI controller mainly consists of a predictive PI controller and a predictor with an integral link. Again, for the integral predictor in the DPPI control strategy, two new regulation parameters are introduced, which can effectively regulate the control performance and robustness of the control system, improve the degree of freedom of the controller design, and give the principles for the adjustment of the DPPI controller parameters. Finally, it has been verified through simulation experiments that the proposed method can significantly improve response speed and effectively resist external perturbations with good control effect and robust stability.
Clinical best practices in interdisciplinary management of human epidermal growth factor receptor 2 antibody‐drug conjugates–induced interstitial lung disease/pneumonitis: An expert consensus in China
Authors: Xu Chunwei , Chen Zhanhong , Xia Yuanli , Shi Yanxia , Fu Peifen , Chen Yiding , Wang Xian , Zhang Lili , Li Hengyu , Chen Wenyan , Fu Jianfei , Huang Liming , Shu Jingde , Wang Ouchen , Wu Weizhu , Xie Bojian , Wang Ting , Zhang Weiping , Shen Shurong , Li Qun , Luo Ting , Zhang Bin , Xie Yanru , Wang Hongxia , Wang Qian , Wang Wenxian , Li Ziming , Song Zhengbo , Fang Wenfeng , Zhong Wenzhao , Zhang Yongchang , Zhan Ping , Liu Hongbing , Lv Tangfeng , Miao Liyun , Min Lingfeng , Wang Feng , Meng Rui , Zhu Youcai , Wang Lin , Wan Bing , Wang Dong , Hao Yue , Zhou Jianya , Huang Long , Zhang Zhang , Lv Donglai , Fang Meiyu , Lu Yuanzhi , Si Lu , Song Yong , Wang Xiaojia 
Published: August 2024

AbstractAntibody–drug conjugates (ADCs) have demonstrated effectiveness in treating various cancers, particularly exhibiting specificity in targeting human epidermal growth factor receptor 2 (HER2)‐positive breast cancer. Recent advancements in phase 3 clinical trials have broadened current understanding of ADCs, especially trastuzumab deruxtecan, in treating other HER2‐expressing malignancies. This expansion of knowledge has led to the US Food and Drug Administration's approval of trastuzumab deruxtecan for HER2‐positive and HER2‐low breast cancer, HER2‐positive gastric cancer, and HER2‐mutant nonsmall cell lung cancer. Concurrent with the increasing use of ADCs in oncology, there is growing concern among health care professionals regarding the rise in the incidence of interstitial lung disease or pneumonitis (ILD/p), which is associated with anti‐HER2 ADC therapy. Studies on anti‐HER2 ADCs have reported varying ILD/p mortality rates. Consequently, it is crucial to establish guidelines for the diagnosis and management of ILD/p in patients receiving anti‐HER2 ADC therapy. To this end, a panel of Chinese experts was convened to formulate a strategic approach for the identification and management of ILD/p in patients treated with anti‐HER2 ADC therapy. This report presents the expert panel's opinions and recommendations, which are intended to guide the management of ILD/p induced by anti‐HER2 ADC therapy in clinical practice.
Filamentous Aerogels for Electromagnetic Shielding
Authors: Rezaei Zahra , Prince Elisabeth , Kamkar Milad 
Published: August 2024

AbstractThe unrelenting expansion of electronics and wireless communications has brought an onslaught of electromagnetic interference and environmental radiation as a new form of pollution. Filamentous aerogels offer a viable solution to this growing challenge: with their hierarchical inter‐ and intra‐filament porosities, they have recently shown great promise as EMI shielding materials. The multidirectional EM wave scattering within their hierarchical porous structure enhances attenuation much higher than conventional monolithic aerogels. This concept paper summarizes recent groundbreaking efforts in filamentous aerogel fabrication, with a focus on liquid streaming and 3D printing approaches. Further research and development could see filamentous aerogels emerge as next‐generation materials to combat the intensification of electromagnetic environmental impacts.
Research on linear active disturbance rejection control strategy based on grid‐forming inverters
Authors: Hu Meng Jie , Tang Yu 
Published: August 2024

AbstractGrid‐forming inverters play a vital role in connecting renewable energy sources to the grid, and maintaining stable output voltage is essential for system operation. However, traditional dual‐PI voltage–current loop control suffers from slow response and weak disturbance rejection, leading to suboptimal control performance of grid‐connected inverter output voltage. Moreover, employing traditional dual‐PI control in grid‐connected inverters results in low output impedance, making them prone to subsynchronous oscillations and instability under strong grid conditions. To address these challenges, this study introduces a novel dual‐loop control strategy based on linear active disturbance rejection control (LADRC), wherein voltage loop is regulated by LADRC while current loop employs PI control. Quantitative analysis and experimental findings demonstrate that compared with traditional dual‐PI voltage–current loop control, the LADRC‐based dual‐loop control strategy offers higher bandwidth and lower steady‐state error, thereby enhancing the tracking speed and precision of grid‐forming inverter output voltage. The LADRC‐based dual‐loop control strategy reduces output impedance in grid‐forming inverter systems, lowering THD of output voltage and improving harmonic suppression under nonlinear loads. Experimental results show its robustness against strong grid conditions compared with traditional dual‐PI control, ensuring stable output voltage.
Genomic analysis of NE Atlantic sardine (Sardina pilchardus) reveals reduced variation in a recently established North Sea population and directs reconsideration of management units
Authors: McKeown Niall J. , Campanella Fabio , Silva Joana F. , Roel Beatriz A. , Healey Amy J. E. , Shaw Paul W. , van der Kooij Jeroen 
Published: August 2024

AbstractThe European sardine (Sardina pilchardus) is under intense fishing pressure and exhibits distributional/abundance shifts linked to environmental change. The current understanding of population demographics needed for sustainable management is uncertain due to concerns that previous genetic studies lacked resolution and limited sampling of sardine north of the Bay of Biscay. To address these issues, we performed mtDNA sequencing and genome wide SNP analysis of samples collected across the Bay of Biscay, Celtic Sea, English Channel and North Sea. The complete SNP data reported a lack of structure throughout the sampled area compatible with high gene flow. A consensus suite of positive outlier SNPs was identified which reported a significant correlation with geographical distance with the largest differentiation between the southern Bay of Biscay and North Sea samples which also reported a significant mtDNA ΦST. While the roles of dispersal limitation and environmental heterogeneity underpinning this require further study, this adds to growing evidence that selection is influencing sardine population structure against a background of high gene flow. The results indicate that while there may be a level of demographic independence between North Sea and South Biscay sardine, the current delimitation of central (Biscay) and northern (Channel and Celtic Sea) operational stocks may misrepresent connectivity between the Biscay and Channel. The North Sea sample exhibited markedly lower mtDNA and nuclear variation than other samples. As sardine have only recently invaded the North Sea such reduced genetic variation is compatible with predictions for peripheral leading‐edge populations but contrasts with patterns for other small pelagic species and emphasises the need to consider species‐specific genetic structure in ecosystem‐based management. Nascent management of the North Sea sardine fishery must ensure that current low levels of genetic diversity are not eroded further as this may decrease the species adaptive potential and inhibit its expansion.
Prognostic value of right atrial function in patients with significant tricuspid regurgitation
Authors: Nishihara Takahiro , Takaya Yoichi , Nakayama Rie , Yoshida Yu , Toh Norihisa , Miyoshi Toru , Nakamura Kazufumi , Yuasa Shinsuke 
Published: August 2024

AbstractAimsAlthough right ventricular (RV) dysfunction is associated with adverse outcomes in tricuspid regurgitation (TR), the potential role of right atrial (RA) function is unknown. We aimed to investigate the relationship between RA function and clinical outcomes in patients with significant TR.MethodsThis retrospective study included 169 outpatients with moderate or severe TR due to left‐sided heart diseases who underwent transthoracic echocardiography between June 2020 and April 2023 (average age, 75 ± 10 years; male, 40%). Patients with atrial fibrillation were excluded from this study due to the inaccuracy of the evaluation using 2D speckle‐tracking echocardiography. RA function was compared between patients with and without events, which were defined as all‐cause mortality or hospitalization due to heart failure. RA function was calculated as RA global longitudinal strain (RAGLS) with the 2D speckle‐tracking echocardiography.ResultsDuring a median follow‐up of 13 months, 19 patients had events (all‐cause mortality: 14 cases, hospitalization due to heart failure: 5 cases). RAGLS was lower in patients with events than in those without events (13% ± 10% vs. 18% ± 9%, P = 0.02). When the patients were categorized into two groups [low RAGLS ≤ 16.2% vs. high RAGLS > 16.2%, high RA volume index (RAVI) ≥ 50 mL/m2 vs. low RAVI < 50 mL/m2], Kaplan–Meier curves showed that patients with low RAGLS had higher event rates than those with high RAGLS (log‐rank test, P = 0.003). Patients with high RAVI had higher event rates than those with low RAVI (log‐rank test, P < 0.001). In the multivariate Cox regression analysis, low RAGLS (≤16.2%) was significantly associated with events in a model that included RV dysfunction (RV fractional area change ≤ 35%) or high RAVI (≥50 mL/m2) (hazard ratio: 4.55, 95% confidence interval: 1.51–13.71, P < 0.01; hazard ratio: 4.57, 95% confidence interval: 1.52–13.79, P < 0.01, respectively).ConclusionsRAGLS is associated with all‐cause mortality and hospitalization due to heart failure in patients with significant TR. Our results suggest that RA function is a sensitive marker for identifying the risk stratification of significant TR.
Influencing and prognostic factors of end‐stage hypertrophic cardiomyopathy
Authors: Zhang Yisen , Xie Wenhui , Dai Yaqing , Wu Zefeng , Lin Yuping , Yang Ming , Hong Huashan 
Published: August 2024

AbstractAimsEnd‐stage hypertrophic cardiomyopathy (ES‐HCM) is a disease with severe complications and a poor prognosis. This study aimed to explore the influencing and prognostic factors of ES‐HCM.Methods and resultsA total of 1282 patients with HCM who were hospitalized for the first time at Fujian Medical University Union Hospital between 1 January 2013 and 30 September 2021 were recorded. The patients with HCM and left ventricular ejection fraction (LVEF) < 50% were defined as having ES‐HCM, and a control group (LVEF ≥ 50%) was generated from the collected medical records of HCM. The patients were matched in a ratio of 4:1 based on age and sex. Logistic regression analysis was used to determine the influencing factors of ES‐HCM. Kaplan–Meier survival analysis was performed to analyse the clinical outcomes of ES‐HCM patients. A total of 250 inpatients with HCM were enrolled in the study; 50 patients had ES‐HCM, and 200 had HCM with LVEF ≥ 50%. The mean age of the patients at enrolment was 62.5 ± 10.3 years, and 215 patients (215/250, 86.0%) were male. The median follow‐up time of the patients was 2.8 (1.4–5.4) years. The incidence of all‐cause death and cardiovascular death in patients with ES‐HCM was higher than those in patients with HCM and LVEF ≥ 50% (22/50 [44.0%] vs. 13/200 [6.5%]; 12/50 [24.0%] vs. 4/200 [2.0%], all P < 0.001). Multivariate logistic regression analysis showed that the influencing factors associated with ES‐HCM included age at first symptom onset (odds ratio [OR] = 0.95, 95% CI [0.90, 1.00], P = 0.042), New York Heart Association (NYHA) class (OR = 7.73, 95% CI [2.93, 20.41], P < 0.001), heart rate (OR = 1.07, 95% CI [1.02, 1.12], P = 0.003), QRS duration (OR = 1.03, 95% CI [1.00, 1.05], P = 0.020), left ventricular end‐diastolic diameter (LVEDD) (OR = 1.15, 95% CI [1.04, 1.28], P = 0.006), left atrial anteroposterior diameter (LAD) (OR = 1.13, 95% CI [1.03, 1.24], P = 0.012), and maximum left ventricular wall thickness (MLVWT) (OR = 0.80, 95% CI [0.68, 0.93], P = 0.005). Among the 50 patients with ES‐HCM, NYHA class (P < 0.001) and heart rate (P = 0.017) were each associated with a higher likelihood and earlier occurrence of heart transplantation or all‐cause mortality in univariate analyses.ConclusionsThe influencing factors for ES‐HCM included the age at first symptom onset, NYHA class, heart rate, QRS duration, LVEDD, LAD, and MLVWT. Both NYHA class and heart rate were related to the prognosis of ES‐HCM.
Experimental implementation of the nonstructural element simulator on shake table (NEST) for an archetype tall building
Authors: Cao Yuteng , Fu Haoran , Qu Zhe 
Published: August 2024

AbstractNonstructural damage, usually predominates in buildings subjected to low to moderate seismic intensities and contributes significantly to business interruption and economic losses. It promotes a rapidly growing need for experimental research and qualification of various types of nonstructural elements in buildings in the recent decades. To provide a novel option of experimentally simulating the realistic boundary conditions for various nonstructural elements in labs, we developed the Nonstructural Element Simulator on Shake Table (NEST), a passively controlled three‐layer substructural testbed driven by existing shake tables. This paper presents the first experimental implementation of NEST on a challenging 42‐story archetype tall building. The dynamic properties of the substructure were tuned to adapt the archetype building and the required shake table motions were solved as a reverse problem by an open‐loop control algorithm. The test results proved the capability of NEST to replicate the history responses of the target floors in the archetype building under either recorded earthquake ground motion or artificial loading protocols for qualification purposes. In all cases, the synthetic relative error in the floor accelerations and the inter‐story drift within the frequency range of interest was less than 5% in the numerical domain and less than 30% in the physical realization. The seismic responses of a variety of nonstructural elements to the substructural motions show that, in the mid‐story of the archetype tall building, the ceiling sustained minimum damage because of the small floor acceleration while the indoor contents slid significantly and even overturned.