bluuebunny/crossref_metadata_2025_split huggingface dataset:
Challenges for mesoscale climatology execution on experimental grid computing systems
Authors: Almeida Eugenio Sper de , Campos Velho Haroldo Fraga de , Preto Airam Jonatas 
Published: February 2013

Abstract
This paper discusses the challenges of executing a long-term application on a computational grid, which generates the climatology of the atmospheric numerical model BRAMS (Brazilian development on Regional Atmospheric Modeling System) using ensemble members. We have developed a workflow that submits climatology to the computational grid composed by three different grid middlewares (OurGrid, OAR/CiGri and Globus) and three clusters (situated in Porto Alegre, São José dos Campos and Cachoeira Paulista—Brazil). The application characteristics demand a processing grid, rather than a data grid, due to intensive computation and data transfer between the geographically distributed grid nodes. We achieved the goal of generating the climatology using a computational grid. However, we observed problems on application performance due data transfer and non-availability of the computational grid. Questions related to data storage/transfer and grid failures must be better treated to ensure application performance.
Whole transcriptome analysis of the ERα synthetic fragment P295‐T311 (ERα17p) identifies specific ERα‐isoform (ERα, ERα36)‐dependent and ‐independent actions in breast cancer cells
Authors: Notas George , Kampa Marilena , Pelekanou Vassiliki , Troullinaki Maria , Jacquot Yves , Leclercq Guy , Castanas Elias 
Published: February 2013

ERα17p is a peptide corresponding to the sequence P295LMIKRSKKNSLALSLT311 of the estrogen receptor alpha (ERα) and initially found to interfere with ERα‐related calmodulin binding. ERα17p was subsequently found to elicit estrogenic responses in E2‐deprived ERα‐positive breast cancer cells, increasing proliferation and ERE‐dependent gene transcription. Surprisingly, in E2‐supplemented media, ERα17p‐induced apoptosis and modified the actin network, influencing cell motility. Here, we report that ERα17p internalizes in breast cancer cells (T47D, MDA‐MB‐231, SKBR3) and induces a massive early (3 h) transcriptional activity. Remarkably, about 75% of significantly modified transcripts were also modified by E2, confirming the pro‐estrogenic profile of ERα17p. The different ER spectra of the used cell lines allowed us to identify a specific ERα17p signature related to ERα as well as its variant ERα36. With respect to ERα, the peptide activates nuclear (cell cycle, cell proliferation, nucleic acid and protein synthesis) and extranuclear signaling pathways. In contrast, through ERα36, it mainly triggers inhibitory actions on inflammation. This is the first work reporting a detailed ERα36‐specific transcriptional signature. In addition, we report that ERα17p‐induced transcripts related to apoptosis and actin modifying effects of the peptide are independent from its estrogen receptor(s)‐related actions. We discuss our findings in view of the potential use of ERα17p as a selective peptidomimetic estrogen receptor modulator (PERM).
Do statistical segmentation abilities predict lexical-phonological and lexical-semantic abilities in children with and without SLI?
Authors: MAINELA-ARNOLD ELINA , EVANS JULIA L. 
Published: February 2013

ABSTRACTThis study tested the predictions of the procedural deficit hypothesis by investigating the relationship between sequential statistical learning and two aspects of lexical ability, lexical-phonological and lexical-semantic, in children with and without specific language impairment (SLI). Participants included forty children (ages 8;5–12;3), twenty children with SLI and twenty with typical development. Children completed Saffran's statistical word segmentation task, a lexical-phonological access task (gating task), and a word definition task. Poor statistical learners were also poor at managing lexical-phonological competition during the gating task. However, statistical learning was not a significant predictor of semantic richness in word definitions. The ability to track statistical sequential regularities may be important for learning the inherently sequential structure of lexical-phonological, but not as important for learning lexical-semantic knowledge. Consistent with the procedural/declarative memory distinction, the brain networks associated with the two types of lexical learning are likely to have different learning properties.
Indices of Cognitive Dysfunction in Relapsing-Remitting Multiple Sclerosis: Intra-individual Variability, Processing Speed, and Attention Network Efficiency
Authors: Wojtowicz Magdalena , Omisade Antonina , Fisk John D. 
Published: February 2013

AbstractImpairments in attention and information processing speed are common in multiple sclerosis (MS) and may contribute to impairments of other cognitive abilities. This study examined attentional efficiency, information processing speed and intra-individual variability in response speed using the Attention Network Test-Interactions (ANT-I) in mildy-affected patients with MS. Thirty-one patients with relapsing-remitting MS and 30 age, sex, and education-matched controls completed the ANT-I, as well as the Paced Auditory Serial Attention Test (PASAT), as a standard clinical measure of information processing efficiency. As expected, patients with MS were slower in reaction time performance on the ANT-I and had poorer performance on the PASAT compared to controls. Patients with MS also demonstrated poorer efficiency in their executive control of attention on the ANT-I, suggesting difficulties with top-down allocation of attention. In addition, the MS group demonstrated greater intra-individual variability in the responses to the ANT-I even when their slower overall response time and other factors such as practice were accounted for. Intra-individual variability was found to best predict group membership compared to PASAT scores and other ANT-I scores. These results suggest that intra-individual variability may provide sensitive, unique and important information regarding cognitive functioning in early MS. (JINS, 2013, 19, 1–8)
Exploring Regimes in Black Hole Scaling
Authors: Heinz Sebastian , Merloni Andrea 
Published: February 2013

AbstractRecent observational evidence suggests the existence of two tracks in the radio-X-ray relation for X-ray binaries. Claims have also been made for deviations from the so-called fundamental plane of black hole activity due to the influence of radiative cooling on synchrotron emission from jets and the relative importance of disk and jet emission. In addition, cases of strongly boosted classes of objects, such as BL Lacs, show evidence for jet emission in their location relative to the fundamental plane. In light of the recent literature activity discussing these issues, we revisit the scaling relations expected for synchrotron emission from jet cores. We review the set of scaling laws expected for different types of emission and discuss their relevance to the new observational data, and the conditions under which breaks in the observed scaling relations should be expected. None of the canonical cases offer a satisfactory explanation for the best fit slope of the steep branch of the radio-X-ray relation in hard-state X-ray binaries.
LOFT: the Large Observatory For X-ray Timing
Authors: Belloni Tomaso M. , Bozzo Enrico ,   (on behalf of the LOFT Consortium)
Published: February 2013

AbstractLOFT, the large observatory for X-ray timing, is a new mission concept competing with other four candidates for a launch opportunity in 2022-2024. LOFT will be performing high-time resolution X-ray observations of compact objects, combining for the first time an unprecedented large collecting area for X-ray photons and a spectral resolution approaching that of CCD-based X-ray instruments (down to 200 eV FWHM at 6 keV). The operating energy range is 2-80 keV. The main science goals of LOFT are the measurement of the neutron stars equation of states and the test of General Relativity in the strong field regime. The breakthrough capabilities of the instruments on-board LOFT will permit to open also new discovery windows for a wide range of Galactic and extragalactic X-ray sources.In this contribution, we provide a general description of the mission concept and summarize its main scientific capabilities.
High-mass X-ray binaries in a cosmological context
Authors: Artale María Celeste , Pellizza Leonardo J. , Tissera Patricia B. , Mirabel I. Felix 
Published: February 2013

AbstractRecent observational and theoretical results suggest that the production rates and luminosities of high-mass X-ray binaries depend on metallicity. To test this prediction, we combine HMXB population synthesis results with numerical simulations of galaxy formation to produce synthetic populations of HMXBs in star-forming galaxies, and compare the model predictions to observations of HMXB populations in nearby and high-redshift galaxies. Our models show a fair agreement with observations only when the HMXB production and luminosities are assumed to depend strongly on metallicity.
Hα photometry of low mass stars in 47 Tucanae: chromospheric activity and exotica
Authors: Beccari Giacomo , De Marchi Guido , Panagia Nino , Pasquini Luca 
Published: February 2013

AbstractWe have used archival Hubble Space Telescope (HST) observations obtained with the Advanced Camera for Surveys (ACS) to study the Hα emission properties of main sequence (MS) stars in the globular cluster 47 Tucanae. An accurate photometric measurement of their Hα equivalent width, allows us to identify objects with large Hα emission. We demonstrate that this method allows us to identify and characterise candidate cataclysmic variables (CVs) with high efficiency, reconciling observations with theoretical predictions on the number of dynamically formed CVs expected in a 47 Tucanae-like globular cluster.
Fast co-evolving behavior of the corona with type-I X-ray bursts in Aql X-1
Authors: Chen Yu-Peng , Zhang Shu 
Published: February 2013

AbstractTaking advantage of the type-I X-ray bursts from the hard surface of a NS of the NS XRB Aql X-1 to probe the purported corona, we found, during the bursts, a clear anti-correlation between the soft and the hard X-rays, which indicates an additional cooling of the corona with the soft X-ray shower fed by the bursts. The phenomenon was also found in IGR J17473-2721, 4U 1636-536 and 4U 1608-522. The time delay between the burst emission and corona emission are different each other, but the time delay are all within 5 seconds. The similarity and difference may be understood that the corona have same mechanism but behave different structure or scale.
Determining the neutron star surface magnetic field strength of two Z sources
Authors: Ding Guoqiang , Huang Chunping , Wang Yanan 
Published: February 2013

AbstractFrom the extreme position of disk motion, we infer the neutron star (NS) surface magnetic field strength (B0) of Z-source GX 17+2 and Cyg X-2. The inferred B0 of GX 17+2 and Cyg X-2 are ~(1–5)×108 G and ~(1–3)×108 G, respectively, which are not inferior to that of millisecond X-ray pulsars or atoll sources. It is likely that the NS magnetic axis of Z sources is parallel to the axis of rotation, which could result in the lack of pulsations in these sources.
Confronting the Models of 3 : 2 QPOs with the Evidence of Near Extreme Kerr Black Hole
Authors: Kotrlová Andrea , Török Gabriel , Šrámková Eva , Stuchlík Zdeněk 
Published: February 2013

AbstractThe black hole mass and spin estimates assuming various specific models of the 3 : 2 high frequency quasi-periodic oscillations (HF QPOs) have been carried out in Török et al. (2005, 2011). Here we briefly summarize some current points. Spectral fitting of the spin a ≡ cJ/GM2 in the microquasar GRS 1915 + 105 reveals that this system can contain a near extreme rotating black hole (e.g., McClintock et al., 2011). Confirming the high value of the spin would have significant consequences for the theory of the HF QPOs. The estimate of a > 0.9 is almost inconsistent with the relativistic precession (RP), tidal disruption (TD), and the warped disc (WD) model. The epicyclic resonance (Ep) and discoseismic models assuming the c- and g- modes are instead favoured. However, consideration of all three microquasars that display the 3 : 2 HF QPOs leads to a serious puzzle because the differences in the individual spins, such as a = 0.9 compared to a = 0.7, represent a generic problem almost for any unified orbital 3:2 QPO model.
Clumped stellar winds in supergiant high-mass X-ray binaries
Authors: Oskinova L. M. , Feldmeier A. , Kretschmar P. 
Published: February 2013

AbstractThe clumping of massive star winds is an established paradigm, which is confirmed by multiple lines of evidence and is supported by stellar wind theory. We use the results from time-dependent hydrodynamical models of the instability in the line-driven wind of a massive supergiant star to derive the time-dependent accretion rate on to a compact object in the Bondi-Hoyle-Lyttleton approximation. The strong density and velocity fluctuations in the wind result in strong variability of the synthetic X-ray light curves. Photoionization of inhomogeneous winds is different from the photoinization of smooth winds. The degree of ionization is affected by the wind clumping. The wind clumping must also be taken into account when comparing the observed and model spectra of the photoionized stellar wind.
Spectral Line Variations of Symbiotic Stars EG And, AG Dra, and BX Mon and Its Interpretation
Authors: Yoon Tae Seog , Kim Soo Hyun , Moon Hyeonwoo , Kim Kyu-Seob , Oh Hyungil 
Published: February 2013

AbstractWe present some results obtained by high resolution spectroscopic observations for symbiotic stars EG And, AG Dra, and BX Mon in recent years which were performed with 1.8-m reflector and echelle spectrograph BOES at Bohyunsan Optical Astronomy Observatory, Youngcheon, South Korea. The variations of Hα emission line during a night and the variations of H Balmer lines and He I emission lines among several analyzed lines over months and years are shown and discussed.
Do Environmental Interventions Impact Elementary School Students' Lunchtime Milk Selection?
Authors: Goto Keiko , Waite Alexandra , Wolff Cindy , Chan Kenny , Giovanni Maria 
Published: February 2013

AbstractThis paper examines whether environmental interventions increase elementary‐school students' selection of white milk in the school cafeteria. At intervention school one, white milk was easily accessible, but students had to ask for chocolate milk. Here, intervention students significantly increased their selection of white milk. Further, there was no significant change in the ratio of white milk consumed to white milk selected during the examined period. At intervention school two, the visual cue of a threefold greater quantity of white compared to chocolate milk did not significantly alter selection patterns. These findings demonstrate that school‐based practices that apply the theory of behavioral economics may offer useful policies and strategies for improving food selections.
propy: a tool to generate various modes of Chou’s PseAAC
Authors: Cao Dong-Sheng , Xu Qing-Song , Liang Yi-Zeng 
Published: February 2013

Abstract
Summary: Sequence-derived structural and physiochemical features have been frequently used for analysing and predicting structural, functional, expression and interaction profiles of proteins and peptides. To facilitate extensive studies of proteins and peptides, we developed a freely available, open source python package called protein in python (propy) for calculating the widely used structural and physicochemical features of proteins and peptides from amino acid sequence. It computes five feature groups composed of 13 features, including amino acid composition, dipeptide composition, tripeptide composition, normalized Moreau–Broto autocorrelation, Moran autocorrelation, Geary autocorrelation, sequence-order-coupling number, quasi-sequence-order descriptors, composition, transition and distribution of various structural and physicochemical properties and two types of pseudo amino acid composition (PseAAC) descriptors. These features could be generally regarded as different Chou’s PseAAC modes. In addition, it can also easily compute the previous descriptors based on user-defined properties, which are automatically available from the AAindex database.
Availability: The python package, propy, is freely available via http://code.google.com/p/protpy/downloads/list, and it runs on Linux and MS-Windows.
Contact: yizeng_liang@263.net
Supplementary information: Supplementary data are available at Bioinformatics online.
Cardiac output response to exercise in relation to metabolic demand in heart failure with preserved ejection fraction
Authors: Abudiab Muaz M. , Redfield Margaret M. , Melenovsky Vojtech , Olson Thomas P. , Kass David A. , Johnson Bruce D. , Borlaug Barry A. 
Published: February 2013

AimsExercise intolerance is a hallmark of heart failure with preserved ejection fraction (HFpEF), yet its mechanisms remain unclear. The current study sought to determine whether increases in cardiac output (CO) during exercise are appropriately matched to metabolic demands in HFpEF.Methods and resultsPatients with HFpEF (n = 109) and controls (n = 73) exercised to volitional fatigue with simultaneous invasive (n = 96) or non‐invasive (n = 86) haemodynamic assessment and expired gas analysis to determine oxygen consumption (VO2) during upright or supine exercise. At rest, HFpEF patients had higher LV filling pressures but similar heart rate, stroke volume, EF, and CO. During supine and upright exercise, HFpEF patients displayed lower peak VO2 coupled with blunted increases in heart rate, stroke volume, EF, and CO compared with controls. LV filling pressures increased dramatically in HFpEF patients, with secondary elevation in pulmonary artery pressures. Reduced peak VO2 in HFpEF patients was predominantly attributable to CO limitation, as the slope of the increase in CO relative to VO2 was 20% lower in HFpEF patients (5.9 ± 2.5 vs. 7.4 ± 2.6 L blood/L O2, P = 0.0005). While absolute increases in arterial–venous O2 difference with exercise were similar in HFpEF patients and controls, augmentation in arterial–venous O2 difference relative to VO2 was greater in HFpEF patients (8.9 ± 3.4 vs. 5.5 ± 2.0 min/dL, P < 0.0001). These differences were observed in the total cohort and when upright and supine exercise modalities were examined individually.ConclusionWhile diastolic dysfunction promotes congestion and pulmonary hypertension with stress in HFpEF, reduction in exercise capacity is predominantly related to inadequate CO relative to metabolic needs.
Spatiotemporal Seed Development Analysis Provides Insight into Primary Dormancy Induction and Evolution of theLepidium DELAY OF GERMINATION1Genes
Authors: Graeber Kai , Voegele Antje , Büttner-Mainik Annette , Sperber Katja , Mummenhoff Klaus , Leubner-Metzger Gerhard 
Published: February 2013

AbstractSeed dormancy is a block to the completion of germination of an intact viable seed under favorable conditions and is an adaptive and agronomically important trait. Thus, elucidating conserved features of dormancy mechanisms is of great interest. The worldwide-distributed genus Lepidium (Brassicaceae) is well suited for cross-species comparisons investigating the origin of common or specific early-life-history traits. We show here that homologs of the seed dormancy-specific gene DELAY OF GERMINATION1 (DOG1) from Arabidopsis (Arabidopsis thaliana) are widespread in the genus Lepidium. The highly dormant Lepidium papillosum is a polyploid species and possesses multiple structurally diversified DOG1 genes (LepaDOG1), some being expressed in seeds. We used the largely elongated and well-structured infructescence of L. papillosum for studying primary dormancy induction during seed development and maturation with high temporal resolution. Using simultaneous germination assays and marker protein expression detection, we show that LepaDOG1 proteins are expressed in seeds during maturation prior to dormancy induction. Accumulation of LepaDOG1 takes place in seeds that gain premature germinability before and during the seed-filling stage and declines during the late maturation and desiccation phase when dormancy is induced. These analyses of the Lepidium DOG1 genes and their protein expression patterns highlight similarities and species-specific differences of primary dormancy induction mechanism(s) in the Brassicaceae.
Study on thermoelastohydrodynamic performance of bearing with surface roughness considering shaft deformation under load in shaft‐bearing system
Authors: Zhao Xiaoyong , Sun Jun , Wang Chunmei , Wang Hu , Deng Mei 
Published: February 2013

PurposeCurrent lubrication analyses of misaligned journal bearings are generally performed under some given preconditions. The purpose of this paper is to calculate the lubrication characteristics of a journal bearing with journal misalignment caused by shaft deformation under load, considering the surface roughness, thermal effect and (thermal and elastic) deformation of bearing surface simultaneously.Design/methodology/approachThe lubrication of bearing was analyzed by average flow model based generalized Reynolds equation. The deformation of bearing surface under pressure or heat of oil film was calculated by compliance matrix method. The compliance matrix was established by finite element analysis. The temperature distributions of oil film and bearing were calculated by energy equation and heat conduction equation.FindingsWhen the thermal deformation of bearing and journal surface is considered, the radius clearance affects not only the value of the maximum oil film pressure and minimum oil film thickness, but also the distribution of oil film pressure and thickness of misaligned bearing. The effect of thermal deformation of bearing on the performance of misaligned bearing is larger than that of elastic deformation of bearing. Whether or not the surface roughness affects the performance of misaligned bearing and the affecting level depends greatly on the condition of deformation of bearing surface.Originality/valueThe surface roughness, thermal effect and (thermal and elastic) deformation of bearing surface were considered simultaneously in the thermoelastohydrodynamic lubrication analysis of bearing with journal misalignment caused by shaft deformation under load. The results of this paper are helpful to the design of the bearing.