bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can civility be taught to Latin-American MBAs? Implications of case-method use for the development of civic behaviour in managerial education
Authors: Helena Jaén María , Reficco Ezequiel , Ossa Marcela 
Published: October 2014

Purpose– The purpose of this paper is to examine the formative potential of the case method on MBA students’ “civility” – the procedural dimension of the ethics field. While a robust literature has focussed on the impact of teaching ethics (content) on students’ behavior, to-date no study has explored the link between the pedagogy used (method) and students behavioral dispositions.Design/methodology/approach– A thorough theory review was conducted, covering the different pedagogy literatures that frame the discussion on the link between learning methods and ethics in general, and civic-minded behavior in particular. Drawing on relevant findings from these literatures, some implications are drawn, and tentative propositions are laid out.Findings– The study seeks to readdress the existing imbalance between the cognitive and the formative aspects of education, placing emphasis on the latter. The paper proposes that, other things being equal, MBA programs that make intensive and systematic use of the case method will foster civility among students. Through the iterative practices embedded in the case method, students internalize a number of behavioral predispositions that form the basis of civic behavior.Practical implications– This paper calls for an approach in managerial education that goes beyond the transmission of knowledge. In particular, the paper emphasize the importance of seeing the MBA as “little schools of democracy,” where civic-oriented inclinations can take root in future business leaders. This finding carries substantial implications for business schools and professors, in Latin America and beyond.Originality/value– The transmission of technical knowledge has traditionally been considered the backbone of managerial education – a purely cognitive process. This paper, on the other hand, seeks to highlight the transformative potential of the MBA through the use of the appropriate learning methodologies - the case method in particular. By focussing on the concept of civility, the paper seek to go beyond the prevailing focus on content among ethics scholars and highlight the relevance of habits as a necessary first step on the shaping of civic-minded business leaders. This paper adds a much needed missing link between learning methods and civic behavior.
Assessing developmental space in teams
Authors: Derksen Karin , de Caluwé Léon , Rupert Joyce , Simons Robert-Jan 
Published: October 2014

Purpose
– The aim of this paper is to develop an instrument to assess the developmental space that teams create; examine whether creating more developmental space leads to greater satisfaction with team results; and decide which of three models best predicts perceived results.

Design/methodology/approach
– The paper presents a quantitative study of individuals (N = 257). An instrument was designed to assess developmental space and was validated with a factor analysis. Multiple regression analyses were used to examine whether creating developmental space led to greater satisfaction with team results.

Findings
– This study confirms the four-factor structure of developmental space suggested by earlier research. Creating more developmental space is positively related to perceived team results.

Practical implications
– This research highlights the importance of creating developmental space and provides teams with an instrument to assess their developmental space as a starting point for improvement.

Originality/value
– The interactions teams use are crucial in explaining the effects of teamwork, but seem underexposed in team research. Creating developmental space is a relatively new concept, hitherto only researched qualitatively. This empirical study extends and endorses previous research on developmental space by providing a quantitative assessment.
Resistance of Uterine Radial Artery Blood Flow was Correlated with Peripheral Blood NK Cell Fraction and Improved with Low Molecular Weight Heparin Therapy in Women with Unexplained Recurrent Pregnancy Loss
Authors: Koo Hwa Seon , Kwak‐Kim Joanne , Yi Hyun Jeong , Ahn Hyun Kyong , Park Chan Woo , Cha Sun Hwa , Kang Inn Soo , Yang Kwang Moon 
Published: October 2014

ProblemTo investigate whether peripheral blood natural killer (pbNK) cell levels are associated with uterine blood flow, and low molecular weight heparin (LMWH) treatment is effective to improve uterine blood flow in women with decreased uterine blood flow and unexplained recurrent pregnancy loss (RPL).Method of studyThis was a prospective controlled study. Study population included 33 pregnant women (between 5 and 7 weeks gestation) with ≥2 RPL and controls were 47 healthy pregnant women. pbNK cell fractions (CD3−/56+/16+) of peripheral blood mononuclear cells were measured by flow cytometry. Uterine color‐pulsed Doppler ultrasound was performed to evaluate uterine radial artery resistance index (URa‐RI). In RPL women with elevated URa‐RI (≥0.5), LMWH (ranges 40–60 mg/day) was administered subcutaneously daily and URa‐RI was reassessed 1 week later. Pregnancy outcome was analyzed at 12 weeks gestation.ResultsURa‐RI was significantly higher in pregnant women with RPL than controls (0.60 ± 0.14 versus 0.54 ± 0.12, P = 0.039). In pregnant women with RPL, pbNK cell fractions displayed a positive correlation with URa‐RI (Pearson's r = 0.429, P = 0.013). URa‐RI was significantly decreased 1 week after LMWH treatment as compared to that of pretreatment (pretreatment RI: 0.65 ± 0.11 versus post‐treatment RI: 0.56 ± 0.13, P = 0.011). Pregnancy outcome of RPL women with LMWH treatment was not different from that of pregnant controls (73.3% versus 85.0%, P = NS).ConclusionIncreased pbNK cells are associated with decreased uterine radial artery blood flow. LMWH treatment effectively decreases URa‐RI with improved pregnancy outcome in women with RPLs and elevated URa‐RI. A larger scale study is needed to verify these findings.
Towards a resource‐based habitat approach for spatial modelling of vector‐borne disease risks
Authors: Hartemink Nienke , Vanwambeke Sophie O. , Purse Bethan V. , Gilbert Marius , Van Dyck Hans 
Published: October 2014

ABSTRACTGiven the veterinary and public health impact of vector‐borne diseases, there is a clear need to assess the suitability of landscapes for the emergence and spread of these diseases. Current approaches for predicting disease risks neglect key features of the landscape as components of the functional habitat of vectors or hosts, and hence of the pathogen. Empirical–statistical methods do not explicitly incorporate biological mechanisms, whereas current mechanistic models are rarely spatially explicit; both methods ignore the way animals use the landscape (i.e. movement ecology). We argue that applying a functional concept for habitat, i.e. the resource‐based habitat concept (RBHC), can solve these issues. The RBHC offers a framework to identify systematically the different ecological resources that are necessary for the completion of the transmission cycle and to relate these resources to (combinations of) landscape features and other environmental factors. The potential of the RBHC as a framework for identifying suitable habitats for vector‐borne pathogens is explored and illustrated with the case of bluetongue virus, a midge‐transmitted virus affecting ruminants. The concept facilitates the study of functional habitats of the interacting species (vectors as well as hosts) and provides new insight into spatial and temporal variation in transmission opportunities and exposure that ultimately determine disease risks. It may help to identify knowledge gaps and control options arising from changes in the spatial configuration of key resources across the landscape. The RBHC framework may act as a bridge between existing mechanistic and statistical modelling approaches.
Novel Peptidomimetics for Inhibition of HER2:HER3 Heterodimerization in HER2‐Positive Breast Cancer
Authors: Kanthala Shanthi , Banappagari Sashikanth , Gokhale Ameya , Liu Yong‐Yu , Xin Gu , Zhao Yunfeng , Jois Seetharama 
Published: October 2014

The current approach to treating HER2‐overexpressed breast cancer is the use of monoclonal antibodies or a combination of antibodies with traditional chemotherapeutic agents or kinase inhibitors. Our approach is to target clinically validated HER2 domain IV with peptidomimetics and inhibit the protein–protein interactions (PPI) of HERs. Unlike antibodies, peptidomimetics have advantages in terms of stability, modification, and molecular size. We have designed peptidomimetics (compounds 5 and 9) that bind to HER2 domain IV, inhibit protein–protein interactions, and decrease cell viability in breast cancer cells with HER2 overexpression. We have shown, using enzyme fragment complementation and proximity ligation assays, that peptidomimetics inhibit the PPI of HER2:HER3. Compounds 5 and 9 suppressed the tumor growth in a xenograft mouse model. Furthermore, we have shown that these compounds inhibit PPI of HER2:HER3 and phosphorylation of HER2 as compared to control in tissue samples derived from in vivo studies. The stability of the compounds was also investigated in mouse serum, and the compounds exhibited stability with a half‐life of up to 3 h. These results suggest that the novel peptidomimetics we have developed target the extracellular domain of HER2 protein and inhibit HER2:HER3 interaction, providing a novel method to treat HER2‐positive cancer.
Identification of Novel Selective Lysine‐Specific Demethylase 1 (LSD1) Inhibitors Using a Pharmacophore‐Based Virtual Screening Combined with Docking
Authors: Zhou Chen , Kang Di , Xu Yungen , Zhang Luyong , Zha Xiaoming 
Published: October 2014

Lysine‐specific demethylase 1 (LSD1) plays an important role in regulating the lysine methylation at residues K4 and K9 on histone H3. High levels of LSD1 expression have been observed in several malignant tumors. In this study, we presented a pharmacophore‐based virtual screening of a moderate database of 171 143 small molecules. A pharmacophore of LSD1 inhibitors was constructed for the first time and then used to screen the compound library combined with validated molecular docking tools followed by biochemical assays, led to the identification of 9 novel LSD1 inhibitors, showing their IC50 values in a range of 2.41–101 μm. Furthermore, compound XZ09 exhibited less inhibition against the homologous monoamine oxidase A (MAO‐A) and B (MAO‐B) displaying its moderate selectivity. Our study provides an effective virtual screening method to identify new LSD1 inhibitors and XZ09 represents a potent and selective lead compound to deserve further optimization for the treatment of LSD1 overexpressing cancers.
Differences in Wake-up and Unknown Onset Stroke Examined in a Stroke Registry
Authors: Reid John M. , Dai Dingwei , Cheripelli Bharath , Christian Christine , Reidy Yvette , Gubitz Gord J. , Phillips Stephen J. 
Published: October 2014

Introduction Debate exists as to whether wake-up stroke (WUS) (i.e. symptoms first noted on waking) differs from stroke developing while awake [awake onset stroke (AOS)]. Unknown onset stroke (UOS) with unclear symptom onset time is infrequently studied. Aims This study aimed to examine differences in stroke characteristics and outcomes in these three groups. Methods The stroke registry database from Halifax Infirmary, Canada, was interrogated for hospitalised stroke patients between 1999–2011. Information was available on demographics, stroke characteristics, and functional status at discharge and six months (modified Rankin score [mRS]). Results Of 3890 patients, 65% had AOS, 21% WUS and 14% UOS. UOS patients were significantly older, more commonly female and living alone than AOS patients, with no difference between AOS and WUS. UOS rates increased from 10 to 16% of patients during the study period ( P < 0·0001). UOS but not WUS had a higher stroke severity than AOS. Intracerebral hemorrhage was less common (9 vs. 13%) and lacunar stroke more common (23 vs. 19%) in WUS compared to AOS. In UOS left hemisphere location was more likely, and lacunar stroke less common. Excellent outcomes were slightly lower for WUS. UOS had significantly higher rates of in-hospital mortality (23 vs. 16%, P < 0·0001) and poorer functional outcome six months after stroke (mRS < 3 in 26% of UOS and 46% of AOS, P = 0·02). Conclusion WUS has lower rates of ICH but similar stroke severity and outcomes to AOS. UOS prevalence appears to be increasing, with higher stroke severity and worse prognosis.
Resistant Hypertension: Risk Factors, Subclinical Atherosclerosis, and Comorbidities Among Adults—The Brazilian Longitudinal Study of Adult Health (ELSA‐Brasil)
Authors: Lotufo Paulo A. , Pereira Alexandre C. , Vasconcellos Paulo S. , Santos Itamar S. , Mill Jose Geraldo , Bensenor Isabela M. 
Published: October 2014

The frequency of resistant hypertension—defined as blood pressure (BP) ≥140/90 mm Hg with proven use of three antihypertensive medications, or as the use of four antihypertensive drug classes regardless of BP—is unknown in low‐middle–income countries. Using data from the Brazilian Longitudinal Study of Adult Health, a cohort of 15,105 civil servants aged 35 to 74 years, the authors identified 4116 patients taking treatment for hypertension, 11% of who had resistant hypertension. These participants were more likely to be older, black, less educated, poorer, and obese. The adjusted prevalence ratios (95% confidence intervals) were diabetes, 1.44 (1.20–1.72); glomerular filtration rate (<60 mL/min/1.72 m2), 1.95 (1.60–2.38); albumin‐to‐creatinine ratio (>300 mg/g), 2.43 (1.70–3.50); carotid‐femoral pulse‐wave velocity, 1.07 m/s (1.03–1.11 m/s); common carotid intima‐media thickness, 2.57 mm (1.64–4.00 mm); left ventricular hypertrophy, 2.08 (1.21–3.57); and atrial fibrillation, 3.55 (2.02–6.25). Thus, the prevalence of resistant hypertension in Brazil is high and associated with subclinical markers of end‐organ cardiovascular damage.
Are there sex differences in placebo analgesia during visceral pain processing? A fMRI study in healthy subjects
Authors: Theysohn N. , Schmid J. , Icenhour A. , Mewes C. , Forsting M. , Gizewski E. R. , Schedlowski M. , Elsenbruch S. , Benson S. 
Published: October 2014

AbstractBackgroundWe explored sex differences in the neural mechanisms mediating placebo analgesia in an established visceral pain model involving painful rectal distensions in healthy volunteers.MethodsN = 15 men and N = 15 women underwent three consecutive functional magnetic resonance imaging sessions during which cued painful rectal distensions were delivered. After an adaptation session, positive expectations were induced with deceptive instructions regarding administration of an analgesic drug (placebo session). In the other session (control), truthful information about an inert substance was given. Sex differences in placebo‐induced modulation of neural activation during anticipation and pain were analyzed along with ratings of expected and perceived pain intensity.Key ResultsPlacebo‐induced reductions in pain ratings were comparable between men and women. At the level of the brain, group comparisons with respect to differences between the placebo and control conditions revealed greater modulation of the posterior insula (regions‐of‐interest analysis: pFWE < 0.05) and dorsolateral prefrontal cortex (whole‐brain analysis: p < 0.001, uncorrected) during pain anticipation in women. During pain, placebo‐induced down‐regulation of the insula was altered in women compared to men (ROI analysis: pFWE < 0.05).Conclusions & InferencesOur data provide first evidence supporting sex differences in pain‐induced neural modulation during visceral placebo analgesia despite similar placebo‐induced reductions in perceived pain intensity. These preliminary findings might contribute to elucidating mechanisms mediating placebo effects in clinical conditions associated with chronic abdominal pain such as in irritable bowel syndrome.
Newborn hypocarnitinemia due to long‐term transplacental pivalic acid passage
Authors: Nasu Takashi , Suzuki Masahiko , Uetake Kimiaki , Kubota Mituru 
Published: October 2014

AbstractInfants often develop hypocarnitinemia and resultant hypoglycemia during long‐term treatment with antibiotics that contain pivalic acid, but it is unknown whether maternal treatment with such agents during pregnancy induces hypocarnitinemia in fetuses or neonates. A woman at week 28 of pregnancy was prescribed cefcapene pivoxil for 84 consecutive days for treatment and prophylaxis of pyelonephritis. Using tandem mass spectrometry, both the mother and newborn were found to have hypocarnitinemia soon after delivery. It was concluded that the baby suffered from secondary hypocarnitinemia due to long‐term prenatal treatment with antibiotics containing pivalic acid. Long‐term treatment with antibiotics containing pivalic acid in pregnant women can induce hypocarnitinemia in both the mother and neonate; reported herein is the first case observed in humans.
CFD Aided Design of Heat Transfer Plates for Gasketed Plate Heat Exchangers
Authors: Özkaya Ece , Aradag Selin , Kakac Sadik 
Published: October 2014

In this study, three-dimensional computational fluid dynamics (CFD) analyses are performed to assess the thermal-hydraulic characteristics of a commercial Gasketed Plate Heat Exchangers (GPHEx) with 30 degrees of chevron angle (Plate1). The results of CFD analyses are compared with a computer program (ETU HEX) previously developed based on experimental results.
Heat transfer plate is scanned using photogrammetric scan method to model GPHEx. CFD model is created as two separate flow zones, one for each of hot and cold domains with a virtual plate. Mass flow inlet and pressure outlet boundary conditions are applied. The working fluid is water. Temperature and pressure distributions are obtained for a Reynolds number range of 700–3400 and total temperature difference and pressure drop values are compared with ETU HEX. A new plate (Plate2) with corrugation pattern using smaller amplitude is designed and analyzed. The thermal properties are in good agreement with experimental data for the commercial plate. For the new plate, the decrease of the amplitude leads to a smaller enlargement factor which causes a low heat transfer rate while the pressure drop remains almost constant.
SBAT: A Stochastic BPMN Analysis Tool
Authors: Herbert Luke T. , Hansen Zaza , Jacobsen Peter 
Published: October 2014

This paper presents SBAT, a tool framework for the modelling and analysis of complex business workflows. SBAT is applied to analyse an example from the Danish baked goods industry.
Based upon the Business Process Modelling and Notation (BPMN) language for business process modelling, we describe a formalised variant of this language extended to support the addition of intention preserving stochastic branching and parameterised reward annotations. Building on previous work, we detail the design of SBAT, a software tool which allows for the analysis of BPMN models. Within SBAT, properties of interest are specified using the temporal logic Probabilistic Computation Tree Logic (PCTL) and we employ stochastic model checking, by means of the model checker PRISM, to compute their exact values.
We present a simplified example of a distributed stochastic system where we determine a reachability property and the value of associated rewards in states of interest for a real-world example from a case company in the Danish baked goods industry. The developments are presented in a generalised fashion to make them relevant to the general problem of implementing quantitative probabilistic model checking of graph-based process modelling languages.
This paper contains three key elements:
1. SBAT description.
2. Case company description.
3. Using SBAT on the case company.
The paper concludes by indicating SBAT’s practical applicability and suggests further research directions.
Thermodynamic Evaluation of Energy Integration and Cogeneration in Ammonia and Urea Production Complexes
Authors: Kirova-Yordanova Zornitza 
Published: October 2014

Energy integration and cogeneration are commonly used in large mineral fertilizer production complexes for many years. Production of nitrogen fertilizers is an energy intensive industry branch consuming about 5200 PJ of fossil fuels, mainly natural gas. Urea is the major straight nitrogen fertilizer with 46% nitrogen content, and the total production of 155 MM metric tons yearly. About 600–900 kg MP or HP steam and 50–120 kWh electricity per ton urea are consumed in modern low energy urea plants.
In this work the exergy method is used to analyze the dependence of the primary energy consumption and GHG emissions in the ammonia and urea production complexes on basic parameters of the subsystems (ammonia and urea production units and CHP plant) and on the allocation of the additional fuel (natural gas) burning and steam generation.
The results show that the most effective allocation scheme depends mainly on the relative efficiencies of the subsystems and mashinery (compressors and steam turbines).
Integrated Methodology for Investigation of Wagon Bogie Concepts by Simulation
Authors: Ahmad S. S. N. , Cole C. , Spiryagin M. , Sun Y. Q. 
Published: October 2014

Implementation of a new bogie concept is an integrated part of the vehicle design which must follow a rigorous testing and validation procedure. Use of multibody simulation helps to reduce the amount of time and effort required in selecting a new concept design by analysing results of simulated dynamic behaviour of the proposed design. However, the multibody simulation software mainly looks at the dynamics of a single vehicle; hence, forces from the train configuration operational dynamics are often absent in such simulations.
Effects of longitudinal-lateral and longitudinal-vertical interactions between rail vehicles have been found to affect the stability of long trains [1,2]. The effect of wedge design on the vertical dynamics of a bogie has also been discussed in [3,4]. It is important to apply the lateral and vertical forces from a train simulation into a single multibody model of a wagon to check its behaviour when operating in train configuration.
In this paper, a novel methodology for the investigation of new bogie designs has been proposed based on integrating dynamic train simulation and the multibody vehicle modelling concept that will help to efficiently achieve the most suitable design of the bogie. The proposed methodology suggests that simulation of any configuration of bogie needs to be carried out in three stages. As the first stage, the bogie designs along with the wagon configurations need to be presented as a multibody model in multibody simulation software to test the suitability of the concept. The model checking needs to be carried out in accordance with the wagon model acceptance procedure established in [5].
As the second stage, the wagon designs need to be tested in train configurations using a longitudinal train dynamics simulation software such as ‘CRE-LTS’ [2], where a train set consisting of the locomotives and wagons will be simulated to give operational wagon parameters such as lateral and vertical coupler force components.
As the third stage, the detailed dynamic analysis of bogies and wagons needs to be performed with a multibody software such as ‘Gensys’ where lateral and vertical coupler force components from the train simulation (second stage) will be applied on the multibody model to replicate the worst case scenario. The proposed methodology enhances the selection procedure of any alternate bogie concept by the application of simulated train and vehicle dynamics. The simulated case studies show that simulation of wagon dynamic behaviour in multibody software combined with data obtained from longitudinal train simulation is not only possible, but it can identify issues with a bogie design that can otherwise be overlooked.