bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Leflunomide Compared to Methotrexate in the Treatment of Moderate to Severe Plaques Psoriasis: A Randomized Controlled Clinical Trial
Authors: Aboelwafa Hany , Abokhodeir Hassan , Ibrahim Doaa Mamdouh , Bedair Nermeen Ibrahim 
Published: July 2024

Introduction: Psoriasis is a chronic inflammatory autoimmune skin disease. Several treatment options are available including topical and systemic options. Methotrexate was the main systemic medication in treating severe psoriasis, yet adverse events can limit its use. Leflunomide is an isoxazole derivative that inhibits the synthesis of pyrimidines, and subsequently inhibits RNA and DNA synthesis. Objective: As available data directly comparing MTX to leflunomide in psoriasis are lacking, this double blinded study was designed to compare the efficacy of methotrexate versus leflunomide in the treatment of moderate to severe psoriasis. Methods: The study included 40 patients (25 males and 15 females) with chronic plaque psoriasis, s. Patients were randomly assigned to one of two equal groups, group A for subcutaneous methotrexate injections and group B for leflunomide (loading dose 100mg daily for the first 3 days then 20 mg daily for 3 months. Disease severity was determined by psoriasis area and severity index (PASI) score before and at the end of treatment The treatment response was evaluated at the baseline and weeks 4, 8 and 12 PASI score. Results: Both groups were matching at the baseline in aspects of gender, age, disease duration and PASI scores Both medications yielded comparable results with no significant difference between both groups in PASI score neither in side effects.. Conclusion: Leflunomide can be as effective as methotrexate in treatment of moderate to severe psoriasis.
Book review: this is me! whatever you say
Authors: Wajdi Majid , Pratiwi Ni Kadek Anjelia Putri , Putra I Komang Agus Januarta Sutisma , Amanah Firda Maulia , Muhamadias Nusrat , Amandari Ni Kadek Pande Anggi 
Published: July 2024

The purpose of writing is to convey to readers whether a book or work deserves a response from the public or not. Besides that, it is also to give considerations to other works of art such as plays, films, and a performance. Because the considerations conveyed by reviewers must be adjusted to the tastes of readers, a review published in a magazine may not be the same. The method we use in reviewing a book entitled "This Is Me" is the reporting method. The reviewers intentionally describe the contents of the book, and expresses the opinion through details that the reviewers select and omit. The reviewers would present the result of the review. This book has the benefit of encouraging readers of any age, whether young or old, to love themselves without having to worry about what other people think. Become a more confident person, and the story teaches the readers that even if someone falls and gets hurt, they have to do their best until it is time to heal. Such mental strength grows when one has the drive to make it even better. This book seems easy to understand because the language used by the author is light and contains many motivational sentences. This book really helps teenagers to believe more in their potential without worrying about other people's comments that harm them. This book manages to package the problem as well as the solution. There are case studies and motivational sentences that can encourage readers. The conclusion is if one feels that one cannot love him or herself, he or she does not know themselves deeply, and they still ignore other people's negative words. This book will guide the readers to solve the personal problems everyone is experiencing. By reading the book, it will make the readers or individuals can do various things without thinking about negative comments from other people.
A captivating journey of memory and healing: A review of a novel book “Sebuah usaha melupakan” by Boy Chandra (2016)
Authors: Wajdi Majid , Setiadewi Ni Putu Chesya Putri , Ratih Ni Kadek Pande Ayu , Dewi Ni Ketut Citra , Suteja Mutira Kristiani , Pridari Ni Made Mira 
Published: July 2024

This study tries to review an Indonesian novel "Sebuah Usaha Untuk Melupakan" (2016). This novel is a thought-provoking novel by Boy Chardra that delves into the intricate web of human emotions, memories, and the powerful journey of healing. Set against the backdrop of a bustling city, the story follows the protagonist as he embarks on a quest to forget a haunting past and find solace in the present. As the novel unfolds, the protagonist encounters a diverse cast of characters who contribute to his transformative journey. Each interaction serves as a catalyst for self-reflection, challenging his perceptions and forcing him to confront the painful memories that haunt him. The narrative weaves seamlessly between past and present, gradually unraveling the layers of the protagonist's history and offering glimpses of hope and redemption. The writer's evocative prose paints a vivid picture of the urban landscape, mirroring the protagonist's internal struggles. The city becomes a metaphorical canvas upon which the protagonist attempts to forge a new identity and escape the clutches of his past. Through atmospheric descriptions and poetic imagery, the author creates a palpable sense of time and place, immersing readers in the protagonist's world. The novel explores universal themes of love, loss, and the intricate nature of memory. The writer skillfully crafts a narrative that not only captivates readers but also prompts them to reflect on their own experiences. The novel serves as a poignant reminder that healing and growth often require confronting one's past, embracing vulnerability, and on a transformative journey towards self-discovery. This novel is a compelling novel that navigates the complex terrain of memory and healing with grace and sensitivity. The writer’s masterful storytelling and introspective exploration of the human condition make this book a memorable read, resonating with readers long after the final page is turned.
Study of the Effect of Pentostam on Some Bacterial Species Isolated from Skin Infections
Authors: AL-Gorani Amal F. 
Published: July 2024

In the current study, Pentostam treatment, used to treat cutaneous leishmaniasis, was used against some types of bacteria isolated from skin infections (Klebsiella and Staphylococcus) to determine the extent of the bacteria's resistance to this treatment. The results showed that staph bacteria were more sensitive than Klebsiella bacteria.
On the Mueller-Hinton medium and measuring the inhibition zone, some types of vitamins were used in this study, such as vitamin C and vitamin B, without and with Pentostam, to determine their effect in increasing or decreasing the effectiveness of Albutostam against bacteria.
The findings demonstrated that vitamin B did not affect the bacteria's sensitivity to vitamin C alone. However, when they were combined with pentostam treatment, the results showed that vitamin B had the effect of reducing the effectiveness of pentostam against staph. Bacteria and klebsiella bacteria, while vitamin C was shown to increase the effect of pentostam treatment on Both types of bacteria.
PKM: IMPLEMENTASI SISTEM INFORMASI BANK SAMPAH BANJARANGKAN ASRI
Authors: Desmayani Ni Made Mila Rosa , Bevi Libraeni Luh Gede , Kusuma Aniek Suryanti 
Published: July 2024

Sistem Informasi Bank Sampah Banjarangkan Asri, berbasis Website dirancang untuk mengatasi permasalahan pada sistem pencatatan transaksi Bank Sampah. Pencatatan transaksi setoran sampah dan penarikan saldo yang masih manual pada buku tabungan menyebabkan potensi kerusakan, kehilangan, dan kesalahan pencatatan pada buku tabungan nasabah. Selain itu, dalam proses pencatatan transaksi, kader juga sering kali lupa mencatat harga sampah, memerlukan waktu yang cukup lama untuk mencari informasi pada tabel daftar harga dasar Bank Sampah. Oleh karena itu diperlukan sistem informasi bank sampah untuk dapat meningkatkan efisiensi, dan efektivitas. Dalam penelitian ini, penulis menggunakan teknik pengembangan waterfall. Tahapan yang pertama yaitu menganalisis kebutuhan, tahap kedua mendesain sistem, tahap ketiga menuliskan kode program, tahap keempat melakukan pengujian sistem, dan tahap yang terakhir yaitu penerapan dan pemeliharaan sistem. Sistem informasi ini dibuat dengan berbasis website dengan menggunakan bahasa pemrograman PHP dan MYSQL serta menggunakan Framework Laravel. Implementasi sistem dapat beroperasi dengan baik, pengujian sistem dilakukan dengan menggunakan metode pengujian Blackbox dengan menguji sejumlah 33 fungsionalitas pada website Bank Sampah Banjarangkan Asri didapatkan hasil 100% valid. Dimana dapat disimpulkan bahwa semua pengujian fungsionalitas dengan menggunakan Black Box testing semuanya berhasil.
Kata Kunci : Sistem Informasi, Bank Sampah Banjarangkan Asri, metode waterfall.
Analysis of the contribution of polymorphisms of hemostasis system genes and folate cycle genes to the genetic presposition to the development of thrombosis in patients with Ph-negative myeloproliferative neoplasia in the Republic of Uzbekistan
Authors: Berger I. V. , Assesorova Yu. Yu. , Makhmudova A. D. 
Published: July 2024

Thrombotic complications often complicate the course of the underlying disease in patients with chronic myeloproliferative neoplasia. However, a thromboembolic condition is not observed in all patients.The aim of the study was to assess the carriage frequency of polymorphic genes of the blood coagulation system and folate metabolism genes and the contribution of genetic variants to the development of thrombosis in patients with chronic Ph-negative myeloproliferative neoplasia (CMPN).Materials and methods. Molecular genetic testing for the presence of genetic variants with an assessment of their frequency of occurrence and allelic load was carried out in 142 patients with CMPN. We studied polymorphisms of the folate cycle genes – A2756G (Asp919Gly) of the MTR gene, C677T (Ala22Val) of the MTHFR gene, A66G (ILe22Met) of the MTRR gene (rs1801394), as well as mutations of the genes of blood coagulation factors – G(455)A of the FGB gene, G20210A of the F2 gene, G10976A (Arg353Gln) of the F7 gene, G1691A (Arg506Gln) of the F5 gene. The study was carried out using real-time polymerase chain reaction (PCR); The biological material for the test was whole blood.Results and discussion. The study showed that only 6 out of 50 (12%) patients with thrombotic complications had no changes in the genes studied, while 88% of patients had one or another genotypic variant, which may indicate a high probability of involvement of a hereditary genetic factor in the development of hypercoagulability and thrombotic complications in patients with chronic MPN.Conclusions. A comprehensive study of the role, interaction and operating conditions of genes that control blood coagulation processes in patients with Ph-negative chronic MPN will make it possible to understand the causes of hemostatic system disorders and develop effective measures to prevent thrombotic complications in this category of patients.
Zwischen Prinzipientreue und Pragmatismus
Authors: Michl Fabian , Mittrop Johanna 
Published: July 2024

Mit seinem Urteil zur Wahlrechtsreform der Ampelkoalition vom 30. Juli 2024 hat das Bundesverfassungsgericht den Kern der Reform – die Zweitstimmendeckung – bestätigt, aber die Sperrklausel partiell beanstandet. Der Beitrag gibt einen ersten Überblick über die wesentlichen Erwägungen des Gerichts und ordnet sie kritisch in den wahlrechtlichen und politischen Kontext ein.
Pengaruh Model Pembelajaran Inkuiri Terbimbing Berbantuan LKS Terhadap Kemampuan Berpikir Kritis Siswa Kelas X SMAK Setia Bakti Ruteng
Authors: Rosalia Mulyani  
Published: July 2024

This study aims to determine the effeck of the guided iquiry learning model assisted by LKS on student’s critical thinking skills. This research subjects were students of class X IIS 2 dan X IIS 4. The result of the halp of SPSS for windows thorough the Mann Whiney test. The results of the hypothesis test show that thevalue of sig (2 table) is < 0,05 so that H0 is rejected and H1 is accepted. This mean that there is an influence of the guided inquiry learning model assisted by LKS on the by critical thinking skills of X IIS students at SMAK Setia Bakti Ruteng the N-gain result for the eksperimental clas is 0,80 with the high category while the control class is 0,70 with the medium category. This shows thet there is an influence with the guided inquiry learning model assisted by LKS.
Strategi Pembelajaran Pendidikan Agama Islam Berbasis Blended Learning
Authors: Firsya Yunia Amanda  , Nurul Ashiqin  , Gusmaneli Gusmaneli  
Published: July 2024

The development of digital technology has brought significant changes to the world of education, including Islamic Religious Education (PAI) learning. These changes are caused by the potential and capabilities of information and communication technology which enable humans to have relationships and fulfill their needs for unlimited information. This article reviews Islamic religious education strategies based on blended learning. Blended learning is an educational method that combines face-to-face learning with online learning. In this article, we will explain how Islamic religious education strategies can be implemented using blended learning. By combining various learning methods and resources, this approach aims to increase the effectiveness of Islamic learning.
Pengaruh Pemberian Posisi Head Up 30° Terhadap Tingkat Kenyamanan Pasien Cedera Kepala Di Ruang Instalasi Gawat Darurat RSUD Tidar Kota Magelang: Case Report
Authors: Muh. Ihya Alimuddin  , Al-Afik  , Cipto Wahyuning Utama  
Published: July 2024

Background: Head injury is a pathophysiological event that occurs after trauma to the head which can cover every part of the head consisting of the scalp, bones and brain tissue or all the organs in the head. Objective: To determine the effect of providing Head Up 30⁰ position on the comfort level of head injury patients. Method: The method in this research is to use a case report with the nursing intervention of providing a Head Up 30⁰ position to the comfort level of head injured patients, carried out for 4 observations every 15 minutes. Results: From the results of the research, nursing intervention was carried out, namely by providing Head Up 30⁰ position for 4 observations every 15 minutes. The results showed that there was a change in comfort level before and after Head Up 30⁰ position was carried out. Conclusion: Based on the results of research conducted by researchers regarding the effect of providing Head Up 30⁰ position on the comfort level of head injury patients in instalation emergency RSUD Tidar, Magelang City obtained from the results of case study research through intervention, it can be concluded that Head Up 30⁰ therapy has an effect on changes. comfort level of mild to moderate head injury patients with changes in oxygen saturation values increasing, intracranial pressure decreasing, and pain scale decreasing.
Asuhan Kebidanan Komprehensif Pada Ny. S Umur 42 Tahun Dengan Kehamilan Resiko Tinggi Umur, Anemia Dan Kekurangan Energi Kronis (KEK) Di Puskesmas Kaliwadas Kabupaten Brebes
Authors: Rizha Yunia Lestari Dewi  , Hafsah Hafsah  , Sri Mulyani  
Published: July 2024

. According to WHO (2019) TB mortality rate (AKI) in the world namely 303,000 people. Maternal Mortality Rate (MMR) in ASEAN (2020), namely amounting to 235/100,000 live births. Based on data from the Ministry of Health Figures Maternal mortality (MMR) in Indonesia in 2020 was 4,627 deaths. Data Health Department (2021) MMR 62 cases. Data from Kaliwadas Community Health Center (2022) MMR 0 case. The aim of this research was to reduce maternal and infant morbidity and mortality rates in Brebes district, especially the Kaliwadas Community Health Center area. This research method is qualitative research, namely a research method carried out by exploring, describing and explaining and predicting a phenomenon that occurs on the basis of it in the field. The results of this research are after carrying out comprehensive midwifery care in Mrs. S is 42 years old with risk factors: age, anemia and CED at the Community Health Center Kaliwadas from the third trimester of pregnancy, childbirth, newborns, postpartum and family planning using Varney and midwifery approaches SOAP found gaps between theory and practice.
Knowledge About Osteoarthritis and Its Related Risk Factors In Fourth Grade Students In Nursing Department Of Alfarabi Collage
Authors: Khudhair Mohsin Raya , Zena Abdullah Khalaf  
Published: July 2024

Introduction Osteoarthritis (OA) is the most common articular disease of the developed country and cause of chronic disability, and may cause joint failure.Currently, it is more prevalent than it used to be, and it is predicted that this tendency will continue as life expectancy and the prevalence of obesity increase.OA is related to age, but is associated with a variety of both modifiable and non-modifiable risk factors, including obesity, lack of exercise, genetic predisposition, bone density, occupational injury, trauma, and gender. It is a major cause of disability in elderly populations around the globe, especially in developed countries. the aim of study to identify Knowledge about osteoarthritis and its related risk factors in fourth grade students in nursing department of Alfarabi collage and to assess Knowledge about osteoarthritis and its related risk factors in fourth grade students in nursing department of Alfarabi collage . methodology The methodology for studying the knowledge about osteoarthritis and its related risk factors in fourth-grade students in the nursing department of Alfarabi College can be utilize a cross-sectional research design to assess the knowledge of fourth-grade nursing students about osteoarthritis and its related risk factors. A convenience sampling method will be used to select participants from the fourth-grade nursing students at Alfarabi College. The sample size will be determined based on the total number of fourth-grade students in the nursing department. Results The sociodemographic characteristics of 256 students at Al-Farabi College were analyzed. The majority of respondents were male (73.8%), over 22 years old (35.3%), and engaged in manual labor (53.0%). The study found that students had higher knowledge about certain aspects of osteoarthritis, such as postmenopausal women being more at risk for osteoporosis than osteoarthritis (87.5%), while their knowledge about female gender as a risk factor was lower (39.4%). Students also had higher knowledge about joint pain as a symptom of osteoarthritis (82.8%) compared to redness in the joint (53.1%).Finally, while there was a high significance between having a first-degree relative with knee osteoarthritis and knowledge, there was no significance between being clinically diagnosed with osteoarthritis and knowledge among the students. Conclusion the study of sociodemographic characteristics and knowledge of osteoarthritis among students at Al-Farabi College revealed that there were significant associations between gender, occupation, awareness of knee osteoarthritis as a disease entity, and having a first-degree relative with knee osteoarthritis with knowledge about the condition. However, there was no significant association between age, being clinically diagnosed with osteoarthritis, and knowledge.
Supply analysis of mushroom in Malang, Indonesia
Authors: Fahlevi Andrew , Rahayu Endang Siti , Antriyandarti Ernoiz 
Published: July 2024

Background: This study aims to determine the factors that influence the supply and elasticity of mushroom supply in Malang. Method: The primary method used in this research is descriptive and analytic. The research location was chosen purposively in Malang. The type of data used is secondary data in the form of time series for 39 months. The data analysis method used is multiple regression linear analysis with the partially adjusted Nerlove Model. Findings: The results showed the variable price of mushrooms, the area of the harvested mushroom, the price of chicken meat, the price of urea fertilizer, and interest rates individually affected the supply of mushrooms in Malang. The variable of mushroom production and the average rainfall had no significant effect. Variables that are elastic in the short term are the area of the harvested mushroom, and elastic in the long term are the area of the harvested mushroom and the price of chicken meat. Conclusion: The mushroom farmer needs production planning to anticipate increases in the price of substitution products. Mushroom farmers are advised to make storage for supply and expand the mushroom house with more substantial materials to increase supply. Novelty/Originality of this study: This analysis provides an in-depth understanding of supply dynamics, identifying key factors that influence supply elasticity in the short and long term. This study offers practical recommendations for mushroom farmers to optimize their production in the face of market fluctuations.
The contemporary issues related to conventional treatment of acne and the way forward
Authors: Abubakar Aisha Baffa , Abduljalal Abdulaziz Sani 
Published: July 2024

Background: People perceive acne as a minority disorder (not a major health concern), but it has a significant impact and burden on the victims. Although conventional drugs are available for its treatment, which are applied directly to the affected skin, such as azelaic acid, benzoyl peroxide, and salicylic acid etc. or formulationAcne vulgaris is a common skin condition that can have a significant impact on individuals, yet conventional treatments often come with various contemporary issues. This paper discusses the contemporary issues related to the conventional treatment of acne and explores a way forward. Acne vulgaris is a chronic inflammatory disorder of the pilosebaceous unit, with a high prevalence globally and in Nigeria. Although conventional drugs are available for treatment, there are several contemporary issues related to their usage that need to be addressed. Method: Relevant literature, including stakeholder reports and studies conducted globally and locally, were searched and reviewed to identify the contemporary issues related to conventional acne treatment. The key contemporary issues identified include economic, environmental, emotional, social, and spiritual concerns. Findings: The economic burden of costly conventional medications makes them inaccessible for many. Environmental issues arise from the use of potentially harmful chemicals that can pollute water sources and contribute to climate change. Acne can also lead to emotional distress, social stigma, and spiritual conflicts, especially due to the side effects of conventional treatments. Given the limitations of conventional treatments, the article recommends the use of scientifically-proven herbal remedies as a promising alternative strategy. Herbs such as tea tree oil, green tea, chasteberry, black seed, and spikeweed have demonstrated antibacterial, anti-inflammatory, and anti-androgenic properties that can effectively manage acne without the adverse effects of conventional drugs. Conclusion: The use of evidence-based herbal medicines offers a way forward in the treatment of acne, addressing the contemporary issues associated with conventional approaches. Further clinical research and regulatory approval are necessary to integrate these herbal remedies into conventional acne management and ensure their widespread and safe use. Novelty/Originality of this article: This study proposes an integrated acne treatment framework that combines conventional therapies with evidence-based herbal medicine. This approach addresses contemporary issues in acne treatment by considering economic, environmental, and socio-cultural aspects.