bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boiling histotripsy exhibits anti-fibrotic effects in animal models of liver fibrosis
Authors: Joung Chanmin , Heo Jeongmin , Pahk Ki Joo , Pahk Kisoo 
Published: July 2024

AbstractLiver fibrosis is a hallmark of chronic liver disease which could lead to liver cirrhosis or liver cancer. However, there is currently lack of a direct treatment for liver fibrosis. Boiling histotripsy (BH) is an emerging non-invasive high-intensity focused ultrasound technique that can be employed to mechanically destruct solid tumour at the focus via acoustic cavitation without significant adverse effect on surrounding tissue. Here, we investigated whether BH can mechanically fractionate liver fibrotic tissue thereby exhibiting an anti-fibrotic effect in an animal model of liver fibrosis. BH-treated penumbra and its identical lobe showed reduced liver fibrosis, accompanied by increased hepatocyte specific marker expression, compared to the BH-untreated lobe. Furthermore, BH treatment improved serological liver function markers without notable adverse effects. The ability of BH to reduce fibrosis and promote liver regeneration in liver fibrotic tissue suggests that BH could potentially be an effective and reliable therapeutic approach against liver fibrosis.
Proposed simplified methodological approach for designing geopolymer concrete mixtures
Authors: Alaneme George Uwadiegwu , Olonade Kolawole Adisa , Esenogho Ebenezer , Lawan Mustapha Muhammad 
Published: July 2024

AbstractThe development of geopolymer concrete offers promising prospects for sustainable construction practices due to its reduced environmental impact compared to conventional Portland cement concrete. However, the complexity involved in geopolymer concrete mix design often poses challenges for engineers and practitioners. In response, this study proposes a simplified approach for designing geopolymer concrete mixtures, drawing upon principles from Portland cement concrete mix design standards and recommended molar ratios of oxides involved in geopolymer synthesis. The proposed methodology aims to streamline the mix design process while optimizing key factors such as chemical composition, alkali activation solution, water content, and curing conditions to achieve desired compressive strength and workability. By leveraging commonalities between Portland cement concrete and geopolymer concrete, this approach seeks to facilitate the adoption of geopolymer concrete in practical construction applications. The proposed mix design guidelines have been validated through examples for concrete cured under different conditions, including outdoor and oven curing. Future research should focus on validating the proposed methodology through experimental studies and exploring cost-effective alternatives for alkali activation solutions to enhance the feasibility and scalability of geopolymer concrete production. Overall, the proposed simplified approach holds promise for advancing the utilization of geopolymer concrete as a sustainable alternative in the construction industry.
Matrix metalloproteinase 9 expression and glioblastoma survival prediction using machine learning on digital pathological images
Authors: Wu Zijun , Yang Yuan , Chen Maojuan , Zha Yunfei 
Published: July 2024

AbstractThis study aimed to apply pathomics to predict Matrix metalloproteinase 9 (MMP9) expression in glioblastoma (GBM) and investigate the underlying molecular mechanisms associated with pathomics. Here, we included 127 GBM patients, 78 of whom were randomly allocated to the training and test cohorts for pathomics modeling. The prognostic significance of MMP9 was assessed using Kaplan–Meier and Cox regression analyses. PyRadiomics was used to extract the features of H&E-stained whole slide images. Feature selection was performed using the maximum relevance and minimum redundancy (mRMR) and recursive feature elimination (RFE) algorithms. Prediction models were created using support vector machines (SVM) and logistic regression (LR). The performance was assessed using ROC analysis, calibration curve assessment, and decision curve analysis. MMP9 expression was elevated in patients with GBM. This was an independent prognostic factor for GBM. Six features were selected for the pathomics model. The area under the curves (AUCs) of the training and test subsets were 0.828 and 0.808, respectively, for the SVM model and 0.778 and 0.754, respectively, for the LR model. The C-index and calibration plots exhibited effective estimation abilities. The pathomics score calculated using the SVM model was highly correlated with overall survival time. These findings indicate that MMP9 plays a crucial role in GBM development and prognosis. Our pathomics model demonstrated high efficacy for predicting MMP9 expression levels and prognosis of patients with GBM.
Passively harmonic dissipative soliton generation in normal dispersion erbium-doped fiber laser using SMS fiber as artificial saturable absorber
Authors: Chen Yu , Tiu Zian Cheak , Tan Sin Jin , Dimyati Kaharudin , Harun Sulaiman Wadi 
Published: July 2024

AbstractPassively harmonic mode-locking has been experimentally demonstrated in an erbium-doped fiber laser with large normal dispersion using single-multi-single mode structure as artificial saturable absorber. By increasing the pump power under the same polarization setting, the mode-locking operation can switch from fundamental mode-locked to 5th order harmonic mode-locked. Highest repetition rate of 4.26 MHz (5th order harmonic) is observed, with pulse width and pulse energy ascertained at 290 fs and 3.0 nJ, respectively. Excellent signal-to-noise ratio (SNR) of above 50 dB is observed for all harmonic orders. The findings validated that SMS structure can be used to generate stable and switchable high order of harmonic mode-locked. The low-cost SMS fiber for harmonic mode-locked generation technique could lay the groundwork for future sustainable industrial growth.
Anxiety, eating disorders and menstrual disturbances risk in Spanish elite female paddlers
Authors: Aquino-Llinares N. , Gavala- González J. , Porras-García M. E. 
Published: July 2024

AbstractAffiliated athletes are frequently subject to higher levels of anxiety due to the intensity of training, competition and many other factors. This anxiety can cause alterations in their health, both physically and mentally, such as menstrual irregularities, eating disorders, etc. In this work we have analysed the anxiety levels of a population of female affiliated paddlers and the possible consequences for their health. The results showed that a third of the female paddlers analysed have a moderate/high risk of suffering from anxiety; and within this group, the less sporting experience the athlete has, the greater the probability is of suffering from anxiety. Moreover, almost half the total of the female paddlers suffers from menstrual dysfunction before an important competition, with this number rising among high performance athletes, even though three out of every four adjust their training schedule to their menstrual cycle. Less-experienced female athletes, who show higher anxiety levels, also present a greater risk of suffering from eating disorders.
Activation of hTREK-1 by polyunsaturated fatty acids involves direct interaction
Authors: Bechard Emilie , Arel Elodie , Bride Jamie , Louradour Julien , Bussy Xavier , Elloumi Anis , Vigor Claire , Soule Pierre , Oger Camille , Galano Jean-Marie , Durand Thierry , Le Guennec Jean-Yves , Moha-Ou-Maati Hamid , Demion Marie 
Published: July 2024

AbstractTREK-1 is a mechanosensitive channel activated by polyunsaturated fatty acids (PUFAs). Its activation is supposed to be linked to changes in membrane tension following PUFAs insertion. Here, we compared the effect of 11 fatty acids and ML402 on TREK-1 channel activation using the whole cell and the inside-out configurations of the patch-clamp technique. Firstly, TREK-1 activation by PUFAs is variable and related to the variable constitutive activity of TREK-1. We observed no correlation between TREK-1 activation and acyl chain length or number of double bonds suggesting that the bilayer-couple hypothesis cannot explain by itself the activation of TREK-1 by PUFAs. The membrane fluidity measurement is not modified by PUFAs at 10 µM. The spectral shift analysis in TREK-1-enriched microsomes indicates a KD,TREK1 at 44 µM of C22:6 n-3. PUFAs display the same activation and reversible kinetics than the direct activator ML402 and activate TREK-1 in both whole-cell and inside-out configurations of patch-clamp suggesting that the binding site of PUFAs is accessible from both sides of the membrane, as for ML402. Finally, we proposed a two steps mechanism: first, insertion into the membrane, with no fluidity or curvature modifications at 10 µM, and then interaction with TREK-1 channel to open it.
Can climate change signals be detected from the terrestrial water storage at daily timescale?
Authors: Huo Fei , Xu Li , Li Zhenhua , Li Yanping , Famiglietti James S. , Chandanpurkar Hrishi A. 
Published: July 2024

AbstractThe global terrestrial water storage (TWS), the most accessible component in the hydrological cycle, is a general indicator of freshwater availability on Earth. The global TWS trend caused by climate change is harder to detect than global mean temperature due to the highly uneven hydrological responses across the globe, the brevity of global freshwater observations, and large noises of internal climate variability. To overcome the climate noise and small sample size of observations, we leverage the vast amount of observed and simulated meteorological fields at daily scales to project global TWS through its fingerprints in weather patterns. The novel method identifies the relationship between annual global mean TWS and daily surface air temperature and humidity fields using multi-model hydrological simulations. We found that globally, approximately 50% of days for most years since 2016 have climate change signals emerged above the noise of internal variability. Climate change signals in global mean TWS have been consistently increasing over the last few decades, and in the future, are expected to emerge from the natural climate variability. Our research indicates the urgency to limit carbon emission to not only avoid risks associated with warming but also sustain water security in the future.
Efficient and markerless gene integration with SlugCas9-HF in Kluyveromyces marxianus
Authors: Zhou Huanyu , Tian Tian , Liu Jingtong , Lu Hong , Yu Yao , Wang Yongming 
Published: July 2024

AbstractThe nonconventional yeast Kluyveromyces marxianus has potential for industrial production, but the lack of advanced synthetic biology tools for precise engineering hinders its rapid development. Here, we introduce a CRISPR-Cas9-mediated multilocus integration method for assembling multiple exogenous genes. Using SlugCas9-HF, a high-fidelity Cas9 nuclease, we enhance gene editing precision. Specific genomic loci predisposed to efficient integration and expression of heterologous genes are identified and combined with a set of paired CRISPR-Cas9 expression plasmids and donor plasmids to establish a CRISPR-based biosynthesis toolkit. This toolkit enables genome integration of large gene modules over 12 kb and achieves simultaneous quadruple-locus integration in a single step with 20% efficiency. As a proof-of-concept, we apply the toolkit to screen for gene combinations that promote heme production, revealing the importance of HEM4Km and HEM12Sc. This CRISPR-based toolkit simplifies the reconstruction of complex pathways in K. marxianus, broadening its application in synthetic biology.
Flexible adaptation of task-positive brain networks predicts efficiency of evidence accumulation
Authors: Weigard Alexander , Angstadt Mike , Taxali Aman , Heathcote Andrew , Heitzeg Mary M. , Sripada Chandra 
Published: July 2024

AbstractEfficiency of evidence accumulation (EEA), an individual’s ability to selectively gather goal-relevant information to make adaptive choices, is thought to be a key neurocomputational mechanism associated with cognitive functioning and transdiagnostic risk for psychopathology. However, the neural basis of individual differences in EEA is poorly understood, especially regarding the role of largescale brain network dynamics. We leverage data from 5198 participants from the Human Connectome Project and Adolescent Brain Cognitive Development Study to demonstrate a strong association between EEA and flexible adaptation to cognitive demand in the “task-positive” frontoparietal and dorsal attention networks. Notably, individuals with higher EEA displayed divergent task-positive network activation across n-back task conditions: higher activation under high cognitive demand (2-back) and lower activation under low demand (0-back). These findings suggest that brain networks’ flexible adaptation to cognitive demands is a key neural underpinning of EEA.
Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity
Authors: Russell Jamie , Chen Luming , Liu Aijie , Wang Jianhui , Ghosh Subarna , Zhong Xue , Shi Hexin , Beutler Bruce , Nair-Gill Evan 
Published: July 2024

AbstractSignals emanating from the T-cell receptor (TCR), co-stimulatory receptors, and cytokine receptors each influence CD8 T-cell fate. Understanding how these signals respond to homeostatic and microenvironmental cues can reveal new ways to therapeutically direct T-cell function. Through forward genetic screening in mice, we discover that loss-of-function mutations in LDL receptor-related protein 10 (Lrp10) cause naive and central memory CD8 T cells to accumulate in peripheral lymphoid organs. Lrp10 encodes a conserved cell surface protein of unknown immunological function. T-cell activation induces Lrp10 expression, which post-translationally suppresses IL7 receptor (IL7R) levels. Accordingly, Lrp10 deletion enhances T-cell homeostatic expansion through IL7R signaling. Lrp10-deficient mice are also intrinsically resistant to syngeneic tumors. This phenotype depends on dense tumor infiltration of CD8 T cells, which display increased memory cell characteristics, reduced terminal exhaustion, and augmented responses to immune checkpoint inhibition. Here, we present Lrp10 as a new negative regulator of CD8 T-cell homeostasis and a host factor that controls tumor resistance with implications for immunotherapy.
Techniques and Surgical Nuances of Management of Comminuted Fronto-Orbital Depressed Fractures: A Single-Surgeon Experience
Authors: Gupta Rahul , Devi B. Indira , Konar Subhas Kanti , Shashidhar Abhinith , Shukla Dhaval 
Published: July 2024

AbstractCompound fronto-orbital depressed fractures (FODFs) are complex fractures involving the frontal and orbital bones, with associated lacerated wounds on the skin. Repairing such fractures is challenging and requires a multidisciplinary approach. Surgical indications include cerebrospinal fluid rhinorrhea, exposed brain matter, frontal sinus fractures, vision impairment, and cosmetic disfigurement. The repair is typically done using titanium implants (low-profile plates [LPPs] and screws) for a good functional outcome.In this case series of 10 patients operated by a single surgeon (RG), we present different techniques for repairing FODF. Early surgery (< 48 hours) was performed to minimize infection risk.Surgical steps included elevation of depressed fragments, dural repair, and reconstruction of orbital walls using LPP. Some cases required inside-out fixation or suture fixation for better alignment of fragments. Autograft was used for severe bone loss.The results showed good functional outcomes with minimal infection rates. Primary single-stage repair using titanium implants provided satisfactory cosmesis. The use of inside-out repair and sutures was beneficial in specific cases.In conclusion, primary repair of FODF with titanium implants is safe and effective, reducing morbidity and cost. Early surgery and proper techniques are crucial for successful outcomes. Longer follow-up is needed to assess long-term viability and bone resorption.
Time- and angle-resolved photoemission spectroscopy with wavelength-tunable pump and extreme ultraviolet probe enabled by twin synchronized amplifiers
Authors: Suzuki Takeshi , Zhong Yigui , Liu Kecheng , Kanai Teruto , Itatani Jiro , Okazaki Kozo 
Published: July 2024

We describe a setup for time- and angle-resolved photoemission spectroscopy with wavelength-tunable excitation and an extreme ultraviolet probe. It is enabled by using the 10 kHz twin Ti:sapphire amplifiers seeded by the common Ti:sapphire oscillator. The typical probe energy is 21.7 eV, and the wavelength of the pump excitation is tuned between 2400 and 1200 nm by using the optical parametric amplifier. The spectral width of the extreme ultraviolet probe is 53 meV, and the time resolution is dependent on the wavelength for the pump, better than 60 fs for the pump energy &gt;0.7 eV. This system enables the pump energy to be matched with a specific interband transition and to probe a wider energy-momentum space. We present the results for the prototypical materials of highly oriented pyrolytic graphite and Bi2Se3 to show the performance of our system.
Development of a 166.6 MHz β = 1 higher-order-mode-damped superconducting cavity
Authors: Guo Lin , Zhang Pei , Zhang Xinying , Dai Jin , Mi Zhenghui , Ma Qiang , Meng Fanbo 
Published: July 2024

The storage ring of the high energy photon source will be driven by five 166.6 MHz β = 1 quarter-wave superconducting cavities operating at 4 K. A higher-order-mode-damped superconducting cavity was designed with excellent rf and mechanical properties based on the successful development of the proof-of-principle cavity. The mechanical design of the dressed cavity was focused on addressing stress safety throughout the processes, tunability, frequency detuning due to pressure fluctuation, and Lorentz force, among other factors. A new liquid helium vessel was designed along with a comprehensive stiffening scheme to mitigate the surging peak stress on the cavity resulting from the significantly unequal beam pipe size. In the first batch, three cavities were manufactured, and surface preparations were carefully conducted to eliminate defects and etching traces while ensuring cleanliness. The cavity’s Q0 at the design voltage of 1.5 MV reached 3.8 × 109 at 4 K, comfortably surpassing the design goal. Field emission onset was not observed during the entire test up to a peak electric field of 60 MV/m, thanks to the optimized processing procedures. Subsequently, one cavity was welded with the newly designed helium vessel and vertically tested at 2 K, achieving an rf performance comparable to the bare cavities, demonstrating the success of the jacketed cavity. This paper presents the design, fabrication, surface preparation, and cryogenic tests of the first higher-order-mode-damped 166.6 MHz β = 1 superconducting cavity.
High-resolution, highly monochromatic, time-framed, x-ray-backlit-imaging diagnostics with dual-channel toroidal crystals
Authors: Du Huiyao , Si Haoxuan , Jiang Li , Yi Shengzhen , Wang Zhanshan , Dong Jiaqin 
Published: July 2024

Here, we developed a high-resolution, dual-channel toroidal-crystal x-ray imager for time-framed x-ray backlit imaging diagnostics using the 4.727 keV helium-like Ti line. We also presented a method for adjusting the dual-channel imager through the self-imaging of a two-dimensional periodic object. Offline x-ray experiments achieved a spatial resolution of ∼5.0 μm in the center and better than 8.0 μm within a field of view (FOV) of ∼2 mm. At the ShenGuang-III prototype laser facility, we obtained imaging results with a spatial resolution of better than 5 μm within an FOV of ±40 µm. This imager thus provides a way of observing with high spatial, temporal, and spectral resolutions to diagnose the behavior of laser-produced plasma.
One-volt oxide based complementary circuit
Authors: Wang Junjie , Lin Xiaoyu , Li Yuxiang , Xin Qian , Song Aimin , Kim Jaekyun , Jin Jidong , Zhang Jiawei 
Published: July 2024

In low-power electronics, there is a substantial demand for high-performance p-type oxide thin-film transistors (TFTs) that are capable of efficient operation at low voltages. In this study, we employ anodization to form an aluminum oxide gate dielectric layer, enabling the fabrication of p-type tin oxide (SnO) TFTs that effectively operate at a low voltage of 1 V. Under optimal device fabrication conditions, the SnO TFT demonstrates an on/off current ratio exceeding 103 and a saturation mobility of 1.94 cm2 V−1 s−1 at 1 V operation. The optimal SnO TFT fabrication conditions are subsequently used to fabricate a complementary inverter, comprising a SnO TFT and an n-type indium gallium zinc oxide TFT, achieving a gain of up to 38 at a 1 V supply voltage. Notably, the inverter’s switching point voltage is finely tuned to the ideal value, precisely half of the supply voltage. This oxide-based complementary inverter showcases promising potential in low-power electronics.
Computational determination of the S1(Ã1A″) absorption spectra of HONO and DONO using full-dimensional neural network potential energy surfaces
Authors: Xiong Feng , Hou Siting , Li Jiayuan , Wang Zhimo , Xie Changjian 
Published: July 2024

The Ã1A″ ← X̃1A′ absorption spectra of HONO and DONO were simulated by a full six-dimensional quantum mechanical method based on the newly constructed potential energy surfaces for the ground and excited electronic states, which were represented by the neural network method utilizing over 36 000 ab initio energy points calculated at the multireference configuration interaction level with Davidson correction. The absorption spectrum of HONO/DONO comprises a superposition of the spectra from two isomers, namely, trans- and cis-HONO/DONO, due to their coexistence in the ground X̃1A′ state. Our calculated spectra of both HONO and DONO were found to be in fairly good agreement with the experiment, including the energy positions and widths of the peaks. The dominant progression was assigned to the N=O stretch mode (20n) associated with trans-HONO/DONO, which can be attributed to the promotion of an electron to the π* orbital of N=O. Specifically, the resonances with higher vibrational quanta were found to be in the domain of the Feshbach-type resonances. The assignments of the spectra and mode specificity therein are discussed.
Constrained communication in EFL and ESL
Authors: Gilquin Gaëtanelle , Meriläinen Lea 
Published: July 2024

Abstract
This study relies on the constrained communication framework to compare the use of embedded inversion in English
as a Foreign Language (EFL) and English as a Second Language (ESL). It is based on several (sub)corpora of EFL and ESL, but also
reference corpora of native English, which differ along the constraint dimensions of language activation (monolingual/bilingual),
proficiency (native users/proficient L2 users/learners), and modality (speech/writing). In addition to these constraint
dimensions, we also investigate the possible effect of linguistic factors that have been claimed to play a role in the use of
embedded inversion. A multifactorial analysis comparing embedded inversion with standard-like indirect questions, supplemented by
a close examination of the patterns of use of embedded inversion, reveals both shared and distinctive features across EFL and ESL.
It also highlights the importance of linguistic factors and variety/L1, and their interaction with communicative constraints.
名物化與「的」字結構
Authors: Lin Jo-wang 
Published: July 2024

抽象的
本文討論朱德熙先生的名詞性標記「的3」，並對他提出的轉指和自指概念作更為深入的形式語意分析。文章首先釐清結構轉指與語境刪略分屬兩類不同語法現象。前者是在「X的」結構裡，對X裡的缺位成分抽象化為個體特徵後，再以iota算子把個體特徵轉化成為個體的語法過程，轉指過程不涉任何中心語名詞或空號代詞，是「X的」結構本身把陳述轉為稱代的語法操作。語境刪略則是「X的N」結構中，中心語名詞N因為語境可復原而將N刪略的現象，此時X可能有缺位成分或是沒有缺位成分。無缺位成分的是自指結構的「X的」，其偽轉指現象牽涉的是中心語名詞的語境刪略。此外，本文提出自指的「X的」與事件屬性名詞N組合時，是透過施用操作來做語意運算，將N的個體論元角色加進X所指稱的事件，同時「X的」透過修飾N的事件論元限制了N的個體指稱範圍，因而是修飾語而不是補語。「X的」和內容名詞的組合則是透過函項運用，把「X的」所表達的命題指定為內容名詞的內容，「X的」的功能是內容名詞的補語。不管是哪種分析下的自指「X的」，「X的」都不表個體特徵，所以無法轉指個體。最後本文也探討施用操作後所產生的新增施用論元在轉指用法上的限制。