bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pregnancy and fetal outcomes following natalizumab exposure in pregnancy. A prospective, controlled observational study
Authors: Ebrahimi Neda , Herbstritt Sandra , Gold Ralph , Amezcua Lilyana , Koren Gideon , Hellwig Kerstin 
Published: August 2014

Background: Safety data on first-trimester natalizumab exposure are scarce, as natalizumab is usually withdrawn three months before pregnancy. Objective: The objective of this paper is to investigate the fetal safety of exposure to natalizumab (Tysabri®) during the first trimester of pregnancy using disease-matched (DM) and healthy control (HC) comparison groups. Methods: A total of 101 German women with RRMS exposed to natalizumab during the first trimester of pregnancy were identified. Birth outcomes in the exposed group were compared to a DM group ( N = 78) with or without exposure to other disease-modifying drugs, and an HC group ( N = 97). Results: A total of 77, 69 and 92 live births occurred in the Exposed, DM and HC groups, respectively. The rates of major malformations ( p = 0.67), low birth weight (<2500 grams) ( p = 1.0) and premature birth ( p = 0.37) did not differ among groups. Higher miscarriage rates ( p = 0.002) and lower birth weights ( p = 0.001) occurred among the Exposed and DM groups, as compared to the HC; however, there was no significant difference between the Exposed and DM groups. Conclusion: Exposure to natalizumab in early pregnancy does not appear to increase the risk of adverse pregnancy outcomes in comparison to a DM group not exposed to natalizumab.
Impact of a pilot pharmacy health-care professional out-of-school time physical activity and nutrition education program with exercise on fourth and fifth graders in a rural Texas community
Authors: Robles Janie , Gutierrez Ashley , Seifert Charles F 
Published: August 2014

Objectives: Childhood obesity continues to be a problem. Children in rural populations are more likely to be overweight or obese and a lack of resources in those areas may contribute to this problem. We aimed to assess the impact of a pilot pharmacy health-care professional out-of-school time vigorous physical activity and nutrition education program on fourth and fifth graders in a rural Texas community. Methods: We conducted a prospective 12-week cohort study from August to November 2012. Thirty-three children, aged 8–11 years, in Bailey County, Texas, were enrolled in the study. Body mass index, body mass index percentile, blood pressure, waist circumference, and a diet preferences and activities knowledge survey were obtained at 0, 4, 8, and 12 weeks. Study participants completed a twice weekly physical activity and nutrition education program with exercise over weeks 1–4 with no intervention during weeks 5–12. Results: Thirty-one (94%) of the 33 children, predominately Hispanic girls, completed the program. Body mass index (−0.30 (95% confidence interval, −0.44 to −0.17); P = <0.0001), body mass index percentile (−2.75 (95% confidence interval, −4.89 to −0.62); P = 0.0026), systolic blood pressure (−1.9 (95% confidence interval, −2.9 to −0.9); P = <0.0001), and waist circumference (−0.47 (95% confidence interval, −0.85 to −0.10); P = <0.0001) mean change decreased between baseline and week 12 with no intervention for 8 weeks. Positive survey results at 3 months indicated a decrease in fried/sweet foods; increase in exercise; decreases in video games and computer use; and a change in knowledge regarding the selection of the most healthy food group servings per day. Conclusion: In this pharmacy health-care directed pilot study, participants had a reduction of body mass index, body mass index percentile, systolic blood pressure, waist circumference, and improvement in certain survey results at the end of 12 weeks despite no further intervention after 4 weeks.
Comparing Stage at Diagnosis Among Patients With Breast Cancer Served by Military and Civilian Medical Care Systems
Authors: Salai Silvija , Rohrer James E. , Peoples George E. , Stoodt Georjean , Danawi Hadi 
Published: August 2014

Background: Breast cancer (BC) remains one of the top causes of cancer-related deaths in women in the United States, and little is known about the differences in access to health care between military and civilians. This study compared the differences in access to health care between military and civilian female patients with BC. In particular, this study examined whether patients with BC, in an equal access health care system such as the military, are diagnosed at an earlier stage of disease process in comparison to the patients with BC in the civilian health care system. Methods: Independent variables included military versus civilian care and demographic variables. Dependent variable was the stage of cancer at diagnosis. This cross-sectional study of 2 groups included data from 2198 women with BC (439 military and 1759 civilian) for years 2004 through 2008. Multiple logistic regression was used to analyze the data. Results: There was no difference in the early BC stage (0, I, and II) diagnosis prevalence rate between the military and the civilian groups (95% confidence interval [CI], P = .15). The logistic regression analysis indicated that both the health systems had equal performance with respect to the stage at diagnosis indicator but found that black patients had higher odds of being in the late stage (III and IV) BC group at diagnosis (1.62 OR, 1.14-2.30 CI, P = .0068) than white patients. Conclusions: Although no difference was found between the performance of the 2 health systems in the early (0, I, and II) versus late stage (III and IV) at diagnosis indicator, this study further confirms the existence of racial disparities in late-stage BC regardless of whether the patient was diagnosed in the civilian or military health system. More research is needed to further investigate the potential explanations of racial disparities other than just differences in access to health care.
In vitro performance of lipid-PLGA hybrid nanoparticles as an antigen delivery system: lipid composition matters
Authors: Hu Yun , Ehrich Marion , Fuhrman Kristel , Zhang Chenming 
Published: August 2014

Abstract
Due to the many beneficial properties combined from both poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) and liposomes, lipid-PLGA hybrid NPs have been intensively studied as cancer drug delivery systems, bio-imaging agent carriers, as well as antigen delivery vehicles. However, the impact of lipid composition on the performance of lipid-PLGA hybrid NPs as a delivery system has not been well investigated. In this study, the influence of lipid composition on the stability of the hybrid NPs and in vitro antigen release from NPs under different conditions was examined. The uptake of hybrid NPs with various surface charges by dendritic cells (DCs) was carefully studied. The results showed that PLGA NPs enveloped by a lipid shell with more positive surface charges could improve the stability of the hybrid NPs, enable better controlled release of antigens encapsulated in PLGA NPs, as well as enhance uptake of NPs by DC.
Hybrid repair of an aortocaval fistula and inferior vena cava external compression caused by an inflammatory aortoiliac aneurysm: a case study
Authors: Banno Tatsuo , Akamatsu Hokuto , Hanaoka Ryota , Toyama Hiroshi , Kato Ryoichi 
Published: August 2014

Abstract

Introduction
We report a case of aortocaval fistula successfully treated by hybrid operation.

Case description
A 73-year-old female suffering from malignant lymphoma and painful leg edema was transferred to our institution. Computed tomography revealed an aortoiliac aneurysm. The inferior vena cava was compressed by displacement of the abdominal aortic aneurysm. The bilateral internal iliac and ovarian veins were markedly dilated. Diagnosis was an aortoiliac aneurysm with aortocaval fistula. The treatment options were open surgery or an intervention with bypass surgery. Because of narrow iliac access for a bifurcated stent graft, aorto-uni stentgraft treatment followed by bypass surgery was finally decided. Following stent graft insertion and iliofemoral artery bypass, the aneurysms and fistula were successfully excluded without endoleaks. To treat the inferior vena cava compression, the kissing technique was used to place bare metallic stents across the bilateral common iliac veins and inferior vena cava, which improved the clinical symptoms.

Discussion and Evaluation
In this aortocaval fistula caused by AAA, a minimally invasive treatment of stentgraft and bypass surgery with venous flow recovery was chosen as a hybrid treatment. Intravascular intervention was the most suitable in this situation. Bare stent placement for venous occlusion was also effective for revascularization of vena cava flow.

Conclusion
Recent advances in endovascular devices, including stent grafts and bare metallic stents, will be helpful for effective noninvasive treatment for aortocaval fistula circulation.
Composition of essential oils of four Hedychiumspecies from Vietnam
Authors: Van Thanh Bui , Dai Do N , Thang Tran D , Binh Nguyen Q , Anh Luu D Ngoc , Ogunwande Isiaka A 
Published: August 2014

Abstract

Background
Vietnam is a country blessed with many medicinal plants widely used as food and for medicinal purposes, and they contain a host of active substances that contribute to health. However, the analysis of chemical constituents of these plant species has not been subject of literature discussion.

Results
In this study, the chemical compositions of essential oils of four Hedychium species, obtained by hydrodistillation, were determined by means of gas chromatography-flame ionization detector (GC-FID) and gas chromatography–mass spectrometry (GC-MS) techniques. Individually, α-pinene (52.5%) and β-pinene (31.8%) were present in the leaf oil of Hedychium stenopetalum Lodd., while linalool (45.2%), (E)-nerolidol (8.7%) and α-pinene (5.0%) were identified in the root. The leaf of Hedychium coronarium J. König was characterized by α-pinene (20.0%), linalool (15.8%), 1,8-cineole (10.7%), α-pinene (10.1%) and α-terpineol (8.6%); while α-pinene (23.6%), α-humulene (17.1%) and β-caryophyllene (13.0%) were identified in the root. Hedychium flavum Roxb., gave oil whose major compounds were α-pinene (22.5%), α-humulene (15.7%) and β-caryophyllene (10.4%) in the leaf; α-humulene (18.9%), β-caryophyllene (11.8%) and α-pinene (11.2%) in the stem, as well as α-pinene (21.8%), linalool (17.5%) and 1,8-cineole (13.5%) in the root. The main constituents of Hedychium ellipticum Buch.-Ham. ex Smith were (E)-nerolidol (15.9%), α-pinene (11.8%) and bornyl acetate (9.2%) in the leaf with 1,8-cineole (40.8%), α-pinene (18.3%) and α-pinene (11.0%) occurring in the root.

Conclusions
Ubiquitous monoterpenes and sesquiterpenes were identified as characteristic markers for Hedychium species. This work is of great importance for the evaluation of Hedychium essential oils grown in Vietnam.
Comparison of cancer incidence among patients with rheumatic disease: a retrospective cohort study
Authors: Chang Sung Hae , Park Jin Kyun , Lee Yun Jong , Yang Ji Ae , Lee Eun Young , Song Yeong Wook , Lee Eun Bong 
Published: August 2014

Abstract
Introduction
Rheumatic diseases (RDs) are associated with different cancers; however, it is unclear whether particular cancers are more prevalent in certain RDs. In the present study, we examined the relative incidence of several cancers in a single homogeneous cohort of patients with different RDs.

Methods
Patients (N = 3,586) diagnosed with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis (DM) or polymyositis were included. Cancer diagnosis was based on histopathology. The 2008 Korean National Cancer Registry served as the reference for calculating standardized incidence ratios (SIRs).

Results
During the follow-up period of 31,064 person-years, 187 patients developed cancer. RA and SLE patients showed an increased risk of non-Hodgkin’s lymphoma (SIR for RA patients = 3.387, 95% confidence interval (CI) = 1.462 to 6.673; SIR for SLE patients = 7.408, 95% CI = 2.405 to 17.287). SLE patients also had a higher risk of cervical cancer (SIR = 4.282, 95% CI = 1.722 to 8.824). SSc patients showed a higher risk of lung cancer (SIR = 4.917, 95% CI = 1.977 to 10.131). Endometrial cancer was increased only in patients with DM (SIR = 30.529, 95% CI = 3.697 to 110.283). RA patients had a lower risk for gastric cancer (SIR = 0.663, 95% CI = 0.327 to 0.998). The mean time between the RD and cancer diagnoses ranged from 0.1 to 16.6 years, with the shortest time observed in patients with DM (2.0 ± 2.1 years).

Conclusions
Different RDs are associated with particular cancers. Thus, cancer surveillance tailored to specific RDs might be beneficial.
Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells
Authors: Frisch Janina , Venkatesan Jagadeesh Kumar , Rey-Rico Ana , Schmitt Gertrud , Madry Henning , Cucchiarini Magali 
Published: August 2014

Abstract
Introduction
The transplantation of genetically modified progenitor cells such as bone marrow-derived mesenchymal stem cells (MSCs) is an attractive strategy to improve the natural healing of articular cartilage defects. In the present study, we examined the potential benefits of sustained overexpression of the mitogenic and pro-anabolic insulin-like growth factor I (IGF-I) via gene transfer upon the biological activities of human MSCs (hMSCs).

Methods
Recombinant adeno-associated vectors (rAAV) were used to deliver a human IGF-I coding sequence in undifferentiated and chondrogenically-induced primary hMSCs in order to determine the efficacy and duration of transgene expression and the subsequent effects of the genetic modification upon the chondrogenic versus osteogenic differentiation profiles of the cells relative to control (lacZ) treatment after 21 days in vitro.

Results
Significant and prolonged expression of IGF-I was evidenced in undifferentiated and most importantly in chondrogenically-induced hMSCs transduced with the candidate rAAV-hIGF-I vector for up to 21 days, leading to enhanced proliferative, biosynthetic, and chondrogenic activities compared with rAAV-lacZ treatment. Overexpression of IGF-I as achieved in the conditions applied here also increased the expression of hypertrophic and osteogenic markers in the treated cells.

Conclusions
These results suggest that a tight regulation of rAAV expression may be necessary for further translation of the approach in clinically relevant animal models in vivo. However, the current findings support the concept of using this type of vector as an effective tool to treat articular cartilage defects via gene- and stem cell-based procedures.
TNFα and IL-1β influence the differentiation and migration of murine MSCs independently of the NF-κB pathway
Authors: Sullivan Catherine B , Porter Ryan M , Evans Chris H , Ritter Thomas , Shaw Georgina , Barry Frank , Murphy Josephine Mary 
Published: August 2014

Abstract
Introduction
Mesenchymal stem cells (MSCs) have the ability to repair and regenerate tissue, home to sites of inflammation, and evade the host immune system. As such, they represent an attractive therapy for the treatment of autoimmune inflammatory diseases. However, results from in vivo murine studies in inflammatory arthritis have been conflicting, and this may be due to the genetic background of the MSCs used. It is known that the inflammatory milieu may influence properties of MSCs and that, in the case of human bone marrow-derived MSCs, this may be mediated by the nuclear factor-kappa-B (NF-κB) pathway. We sought to determine whether pro-inflammatory cytokines altered the differentiation and migration capacity of murine MSCs from different mouse strains and whether this was mediated by NF-κB.

Methods
The differentiation and migration of FVB and BALB/c MSCs were carried out in the presence of varying concentrations of tumor necrosis factor-alpha (TNFα) and interleukin (IL)-1β, and the NF-κB pathway was inhibited in one of two ways: either by transduction of MSCs with an adenoviral vector expressing a super-repressor of NF-κB or by the addition of curcumin to culture media.

Results
Both BALB/c and FVB MSCs were sensitive to the effect of pro-inflammatory cytokines in vitro. TNFα and IL-1β suppressed BALB/c osteogenesis and adipogenesis and FVB osteogenesis. The migration of both cell types toward media containing fetal bovine serum was augmented by pre-stimulation with either cytokine. In neither cell type were the cytokine effects reversed by abrogation of the NF-κB pathway.

Conclusions
These data show that murine MSCs from different genetic backgrounds may be influenced by an inflammatory milieu in a manner that is not mediated by NF-κB, as is the case for human MSCs. This is not mediated by NF-κB. These findings are important and should influence how in vivo trials of murine MSCs are interpreted and the future development of pre-clinical studies in inflammatory diseases.
The A-to-Z of faulting in the offshore Arabian Gulf: Arabian trend structures overprinted by a Zagros wrench-fault assemblage
Authors: Beck Byron J.-J. 
Published: August 2014

Abstract.Most major fields in the northeastern area of Saudi Arabia and Kuwait are anticlinal structures developed above north-northeast–south-southwest-trending basement lineaments. Based on structural interpretation of 3D seismic data sets, the fault pattern over one such field in the offshore Arabian Gulf of Kuwait and Saudi Arabia was analyzed in detail and integrated into the regional tectonic framework. Two discrete fault sets were identified. First, a system of Cretaceous extensional block faulting was observed that is parallel to and associated with folding over the basement structure. Second, a complex wrench-fault assemblage was identified associated with a Palaeogene dextral couple across the Zagros suture, which overprinted the inherited structural fabric. Convex-upward, Zagros-parallel flower structures were interpreted along with coeval synthetic and antithetic strike-slip fault systems. The interpretation of two discrete faults sets was then applied to an adjacent field that proved to have experienced a more complex tectonic history. Integration of the seismic fault interpretation into the regional tectonic history provided a robust framework that enhanced the understanding of the fault pattern and the structural interpretation of a nearby more complex field.
The First Detection of Phthalimides in Sediments as Novel Biomarkers for Photosynthetic Organisms
Authors: Nomoto Shinya , Araki Suzuko , Mita Hajime 
Published: August 2014

Abstract
We detected a homologous series of phthalimides in organic solvent extracts of Cretaceous to Quaternary sediments. 2-Ethyl-3-methylmaleimide has been found in present-day sediments as a degradation product of chlorophylls; therefore, an authentic sample was heated, affording phthalimide and its homologs as well as homologs of maleimide. The heating products showed a similar molecular distribution of phthalimide and methylphthalimides to those found in the sediments analyzed. These results suggest that the phthalimides found in old sediments are derived from chlorophylls via 2-ethyl-3-methylmaleimide by geochemical transformation.
Identification of a Diesel Engine using Advanced Dynamic Local Affine Models
Authors: Zimmerschied Ralf 
Published: August 2014

Abstract
Nonlinear system identification using local affine models is
investigated with the focus on the structure of the submodels. In
general, submodels in input/output form are applied whose
parameters change simultaneously. In many cases this submodel structure results in an
insufficient model quality in terms of generalization performance
and interpretability. As improvement a new submodel structure with a
delayed parameter change is used as well as an extended offset
with an independent numerator dynamics. This submodel structure is applied for the identification
of the air path of a simulated and a real diesel engine which is equipped with an external exhaust gas recirculation
and a turbocharger with variable geometry turbine.
Parametric Model Order Reduction of Port-Hamiltonian Systems by Matrix Interpolation
Authors: Giftthaler Markus , Wolf Thomas , Panzer Heiko K. F. , Lohmann Boris 
Published: August 2014

Abstract
In this paper, parametric model order reduction of linear time-invariant systems by matrix interpolation is adapted to large-scale systems in port-Hamiltonian form. A new weighted matrix interpolation of locally reduced models is introduced in order to preserve the port-Hamiltonian structure, which guarantees the passivity and stability of the interpolated system. The performance of the new method is demonstrated by technical examples.
Black-box Modeling with Uncertain Parameters from Measurement Data with Unknown, but Bounded Errors
Authors: Zaiser Stefan , Buchholz Michael , Dietmayer Klaus 
Published: August 2014

Abstract
In literature, identification of models with uncertain parameters is restricted to parameter identification. This paper presents a method for system identification with unknown, but bounded measurement errors for linear, time-invariant systems. For each system output, the method determines a model order in a first step, and estimates the uncertain parameters in a second step, both from interval measurement data due to the unknown, but bounded errors. It results in a discrete-time model description with interval parameters. The method is demonstrated and discussed using simulated data as well as measurements.
Methoden zur Modellierung ordnungs- und strukturvariabler Antriebssysteme
Authors: Herchenhan Michael 
Published: August 2014

Zusammenfassung
Oft sind Ordnung und Struktur antriebstechnischer Systeme variabel, weil Kupplungen zum Einsatz kommen. Für die Modellierung resultiert daraus der Bedarf jeweils einer separaten mathematischen Beschreibung für jede mögliche Struktur. Der Modellierungsaufwand steigt schlimmstenfalls exponentiell mit der Anzahl der Schaltglieder. Im vorliegenden Beitrag wird deshalb eine Methode vorgestellt, die den Arbeitsaufwand bei der Modellierung verlustbehafteter Antriebssysteme erheblich reduziert. Als Anwendungsbeispiel wird ein leistungsverzweigter Hybridantrieb betrachtet.
The Role and Challenges of Free-space Optical Systems
Authors: Chaudhary Sushank , Amphawan Angela 
Published: August 2014

AbstractComplementing wireless radio networks with free-space optics (FSO) achieves high data rates by modulating radio subcarriers over an optical carrier without expensive optical fiber cabling, enabling a pervasive platform for reaching underserved areas. In this paper, we review the main features of FSO for terrestrial and inter-satellite communications. Simulations of 1 Gbps data transmission through FSO links in both terrestrial and inter-satellite communications have been investigated to highlight potential atmospheric challenges in FSO.
New records of Rhinolophus beddomei Andersen, 1905 (Chiroptera: Rhinolophidae) from central peninsular region of India, including echolocation call characteristics
Authors: Srinivasulu Chelmala , Srinivasulu Bhargavi , Kaur Harpreet , Shah Tariq Ahmed , Devender Gundena 
Published: August 2014

AbstractThe nominate subspecies of the lesser woolly horseshoe bat