bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Great Genotyper: A Graph-Based Method for Population Genotyping of Small and Structural Variants
Authors: Shokrof Moustafa , Abuelanin Mohamed , Brown C.Titus , Mansour Tamer A. 
Published: July 2024

1AbstractLong-read sequencing (LRS) enables variant calling of high-quality structural variants (SVs). Genotypers of SVs utilize these precise call sets to increase the recall and precision of genotyping in short-read sequencing (SRS) samples. With the extensive growth in availabilty of SRS datasets in recent years, we should be able to calculate accurate population allele frequencies of SV. However, reprocessing hundreds of terabytes of raw SRS data to genotype new variants is impractical for population-scale studies, a computational challenge known as the N+1 problem. Solving this computational bottleneck is necessary to analyze new SVs from the growing number of pangenomes in many species, public genomic databases, and pathogenic variant discovery studies.To address the N+1 problem, we propose The Great Genotyper, a population genotyping workflow. Applied to a human dataset, the workflow begins by preprocessing 4.2K short-read samples of a total of 183TB raw data to create an 867GB Counting Colored De Bruijn Graph (CCDG). The Great Genotyper uses this CCDG to genotype a list of phased or unphased variants, leveraging the CCDG population information to increase both precision and recall. The Great Genotyper offers the same accuracy as the state-of-the-art genotypers with the addition of unprecedented performance. It took 100 hours to genotype 4.5M variants in the 4.2K samples using one server with 32 cores and 145GB of memory. A similar task would take months or even years using single-sample genotypers.The Great Genotyper opens the door to new ways to study SVs. We demonstrate its application in finding pathogenic variants by calculating accurate allele frequency for novel SVs. Also, a premade index is used to create a 4K reference panel by genotyping variants from the Human Pangenome Reference Consortium (HPRC). The new reference panel allows for SV imputation from genotyping microarrays. Moreover, we genotype the GWAS catalog and merge its variants with the 4K reference panel. We show 6.2K events of high linkage between the HPRC’s SVs and nearby GWAS SNPs, which can help in interpreting the effect of these SVs on gene functions. This analysis uncovers the detailed haplotype structure of the human fibrinogen locus and revives the pathogenic association of a 28 bp insertion in the FGA gene with thromboembolic disorders.
Traumatic Encephalopathy Syndrome in the Late Effects of Traumatic Brain Injury (LETBI) study cohort
Authors: Dams-O’Connor Kristen , Selmanovic Enna , Pruyser Ariel , Spielman Lisa , Bulas Ashlyn , Watson Eric , Mez Jesse , Hoffman Jeanne M. 
Published: July 2024

ABSTRACTBackground and ObjectiveTraumatic encephalopathy syndrome (TES) is the proposed clinical manifestation of chronic traumatic encephalopathy (CTE) neuropathologic change secondary to repetitive head impacts (RHI). The prevalence of TES and its component symptoms is not known in individuals with single TBI, a subset of whom also have RHI. We used prospectively collected data to operationalize TES criteria and test the hypothesis that the core clinical features of TES are common among those with TBI, regardless of RHI exposure status and other demographic and injury characteristics.MethodsSecondary analysis of data from the Late Effects of TBI (LETBI) study, a community-based study of individuals with complicated mild, moderate, or severe TBI. Participants were categorized by TBI severity and presence of RHI, creating 6 groups (those with isolated mild, moderate, and severe TBI, with and without RHI). Chi-squared tests were used to compare the proportion of each group that met each of the core clinical criteria overall TES diagnosis. Binary logistic regression models were used to examine associations of demographic and injury characteristics on TES diagnosis.ResultsIn 295 participants with TBI, mean (SD) age 52.6(15.6) years and 35.6% female, 138 (46.8%) had RHI exposure meeting the TES criteria exposure threshold. In the full sample, 56.9%, 32.9% and 45.8% of participants met TES core criterion of cognitive impairment, neurobehavioral dysregulation, and progressive course of clinical features, respectively. Overall, 14.9% of the LETBI sample had substantial RHI exposure and met all 3 clinical features, meeting consensus-based TES criteria. When RHI exposure criterion was lifted, 33.5% of the LETBI sample with isolated TBI met all core clinical criteria. No injury or demographic variables predicted the likelihood of meeting TES Core Criteria (OR=3.02, p=0.10).DiscussionRates of TES clinical features are high among TBI survivors with and without RHI, across injury severity groups. Presence of TES core clinical features was greatest among those with no RHI, suggesting that chronic and sometimes progressive clinical sequelae of TBI resemble TES, but may reflect a distinct pathobiological process. Limitations include possible selection of participants with chronic symptoms. Findings emphasize the centrality of RHI exposure to TES diagnostic criteria.
Segmental MRI Pituitary and Hypothalamus Volumes post Fontan: An analysis of the Australian and New Zealand Fontan Registry
Authors: Gee Waverley , Yang Joseph Yuan-Mou , Gentles Tom , Bastin Sonja , Iyengar Ajay J , Chen Jian , Han Dug Yeo , Cordina Rachael , Verrall Charlotte , Jefferies Craig ,   The Australian and New Zealand Fontan Registry
Published: July 2024

AbstractObjectiveShort stature, central hypothyroidism and infertility are common in those with a Fontan circulation. Given that the Fontan circulation often results in hepatic portal venous congestion, we hypothesize that the hypothalamic-pituitary portal circulation is also affected, contributing to subsequent hypothalamic-pituitary axis dysfunction.MethodsMRI data from the Australian and New Zealand Fontan Registry (86 cases) was compared to 86 age- and sex- matched normal published controls. Total pituitary volumes (both anterior and posterior glands) were measured using a manual tracing segmentation method, and hypothalamic (and subunit) volumes using an automated segmentation tool. Measured gland volume was normalized to total brain volumes. A generalized linear model was used for statistical analysis.ResultsNormalized total pituitary volumes (nTPV) were increased in Fontan patients compared to controls (p<0.0001), due to an increase in anterior pituitary volumes (nAPV) (p<0.0001), with no difference in normalized posterior pituitary volumes (p= 0.7). Furthermore, normalized anterior and tubular hypothalamic subunit groups) were increased in Fontan patients compared to the controls (p<0.01 andp<0.0001, respectively).The time between Fontan and MRI was positively related to nTPV, nAPV and bilateral hypothalamic volumes. nTPV increased with age, and the increase in nAPV was greater in Fontan patients.ConclusionsSegmental MRI Pituitary and Hypothalamus volumes post Fontan are increased and are related to the time since Fontan procedure. These findings are consistent with venous congestion of the anterior hypothalamic-pituitary portal venous system and may explain the high frequency of endocrine dysfunction in this patient group.
The implementation of Lean Six Sigma for the optimization of robotic process automation systems in financial service operations
Authors: Lameijer Bart , de Vries Elizabeth S.L. , Antony Jiju , Garza-Reyes Jose Arturo , Sony Michael 
Published: July 2024

PurposeMany organizations currently transition towards digitalized process design, execution, control, assurance and improvement, and the purpose of this research is to empirically demonstrate how data-based operational excellence techniques are useful in digitalized environments by means of the optimization of a robotic process automation deployment.Design/methodology/approachAn interpretive mixed-method case study approach comprising both secondary Lean Six Sigma (LSS) project data together with participant-as-observer archival observations is applied. A case report, comprising per DMAIC phase (1) the objectives, (2) the main deliverables, (3) the results and (4) the key actions leading to achieving the presented results is presented.FindingsKey findings comprise (1) the importance of understanding how to acquire and prepare large system generated data and (2) the need for better large system-generated database validation mechanisms. Finally (3) the importance of process contextual understanding of the LSS project lead is emphasized, together with (4) the need for LSS foundational curriculum developments in order to be effective in digitalized environments.Originality/valueThis study provides a rich prescriptive demonstration of LSS methodology implementation for RPA deployment improvement, and is one of the few empirical demonstrations of LSS based problem solving methodology in industry 4.0 contexts.
Perceptions of non-formal education by gender, level of education and field of study
Authors: Berková Kateřina , Krpálková Krelová Katarína , Kubišová Andrea , Frendlovská Dagmar , Krpálek Pavel 
Published: July 2024

PurposeMany studies point out that a complication in the professional training is connected with the division of education into the formal and non-formal part. There is a need to integrate these two components to achieve a greater learning effect. The aim of the study is to find out whether students perceive non-formal education as important and to identify which form of extracurricular education they prefer. The aim of this study is to find the relationships among the variables of the educational process of young people.Design/methodology/approachAround 844 Czech secondary and tertiary students participated in the study. The participants expressed their attitudes towards non-formal education through a questionnaire. Welch’s ANOVA test and Games-Howell’s Post-Hoc test were used to verify the hypotheses. Pearson’s correlation coefficient was used to determine correlation relationships.FindingsStudents perceive non-formal education as important. The importance was perceived significantly least by high school and beginning university students in technical fields. Digital forms of education are favoured by students. Significant differences in this area are connected with the different field of study. Students are interested especially in the particular area of non-formal education that is connected with their field of study.Originality/valueThe study provides desirable results in relation to the possible adaptation of education to the needs of students. The article reminds that digital education is promoted because of its flexibility and changing competencies. Specific forms of non-formal education will be appropriate to differentiate according to the fields and the age of students.
Better things to do or doing nothing at all? – the implications of incomplete share repurchase programs
Authors: Vogel Julian U. N. 
Published: July 2024

Purpose Share repurchase programs are the most important form of payout, yet the implications of incomplete share repurchase programs have not been examined in previous literature. This study tests whether incomplete share repurchase programs are seen as a positive or as a negative signal by investors.Design/methodology/approach The perception of incomplete share repurchase programs by algorithmic traders, institutional investors and analysts is analyzed with structural equation models, seemingly unrelated regressions, propensity score matching and buy-and-hold abnormal returns on data from share repurchase programs in the United States. In contrast to previous literature, algorithmic trading is appropriately estimated as a latent variable, leading to more reliable results. Furthermore, decisions about share repurchases and dividends are appropriately modeled simultaneously and iteratively, based on findings from previous literature.Findings The results show that sophisticated investors such as algorithmic traders, institutional investors and financial analysts avoid incomplete share repurchase programs over a long-term investment horizon. Thus, incomplete share repurchase programs are interpreted as negative signals. Additional analyses reveal that share repurchase programs are not completed due to insufficient cash flow, as a result of financial difficulties. Overall, this implies that financial managers should be careful to announce share repurchase programs they know cannot be completed, similar to dividends that cannot be maintained over a long-term horizon.Originality/value This study is the first to consider incomplete share repurchase programs. The findings are of interest to scholars and practitioners, as this study goes beyond narrow repurchase program announcement windows, and instead focuses on the longer-term investment horizon over the life of the share repurchase program, which is often ignored in prior research.
Social innovation for inclusion and sustainable development: a case study on BRAC institute of skills development (BISD)
Authors: Kabir Mohammad Rabiul , Tania Ishrat Jahan , Rubel Mohammad Ahsan Kabir 
Published: July 2024

PurposeThe paper aims to understand the stages of the social innovation process and how it can be used for sustainable development.Design/methodology/approachThis single case study used multiple sources, especially data from extensive field visits and selective in-depth interviews. Direct observation, web content analysis, journals, annual reports and news articles were also used.FindingsThe findings show that BRAC institute of skills development (BISD) adopted a unique formula for the social innovation process: problem identification, new idea, design prototype, pilot, perfect and scale up. This study also finds that BISD has a significant socio-economic impact in Bangladesh. The impacts of BISD are associated with several United Nations (UN) Sustainable Development Goals (SDGs), including SDG 1 on poverty, SDG 4 on inclusive learning, SDG 5 on gender equality and women empowerment, SDG 8 on decent work and economic growth and SDG 16 on social inclusion.Practical implicationsThe discussions of this study ultimately pave a clear roadmap for policymakers, practitioners and academics to improve mechanisms for sustainable development through social innovations in emerging countries.Originality/valueThis paper provides a practical application of the social inclusive innovation process theory by which vocational training institutes can scale their sustainable impact. More knowledge is needed on how organisations can implement social innovation projects in emerging countries. This paper provides exploratory evidence to fill this gap. It demands a promising area of interest to investigate further research on the compatibility of social innovation in skills development programmes to gear up the status of an underprivileged community.
The underlying mechanism of user response to AI assistants: from interactivity to loyalty
Authors: Ko Minjeong , Lee Luri , Kim Yunice YoungKyoung 
Published: July 2024

PurposeWith the expansion of artificial intelligence (AI) technology in everyday life, it is critical to discuss how and why consumers respond in certain ways to AI agents. However, few studies have examined the mechanisms underlying users’ responses to these agents. This study aims to identify such mechanisms and discuss how users form loyalty toward AI agents. Specifically, this study addresses interactivity with AI voice assistants as a key determinant of user loyalty, presenting user perceptions of the human-likeness of AI voice assistants and communication self-efficacy as sequential mediators.Design/methodology/approachWe investigate the effects of human-likeness and communication self-efficacy on the relationship between interactivity and loyalty to AI voice assistants by developing a sequential mediation model. To estimate the empirical model, data were collected through an online survey with 330 respondents.FindingsThe results indicate that interactivity influences loyalty directly and positively. In addition, interactivity affects loyalty indirectly sequentially through human-likeness and communication self-efficacy.Originality/valueBy uncovering the psychological mechanisms underlying users’ loyalty to AI voice assistants, this study provides new academic and managerial insights that have not been clearly identified in the current literature.
Conspiratorial thinking in the workplace: how it happens and why it matters
Authors: Tam Lisa , Lee Hyelim , Kim Jeong-Nam 
Published: July 2024

PurposeAlthough belief in conspiracy theories has been researched since the 1970s, specific research on conspiratorial thinking in the workplace is scarce. Conspiratorial thinking could be fostered among employees in workplaces because of unequal power relations resulting from the organizational hierarchy. This study examines workplace conspiracy attribution (WCA) as employees’ attribution of problematic events in the workplace as being plotted by powerful actors within their organizations and tests its antecedents and consequences.Design/methodology/approachA survey dataset collected from employees in South Korea (N = 600) was used. This study tested three variables (i.e. two-way communication, employee–organization relationship quality, and perceived ethical orientation) as antecedent conditions of WCA and two outcome variables (i.e. turnover intention and whistleblowing potential) as consequences.FindingsPerceived ethical orientation mediates the relationship between two-way communication and WCA. WCA was found to be positively associated with turnover intention and whistleblowing potential.Originality/valueThis study adopts a public relations lens to understand the significant roles of WCA in reducing turnover intention and whistleblowing potential. It expands existing knowledge of the significance of power and power disparities in organizations.
Heuristic algorithm tool for planning mass vaccine campaigns
Authors: Rodríguez-Pereira Jessica , Ramalhinho Helena , Sarrà Paula 
Published: July 2024

Purpose
The planning of massive vaccination campaigns often falls to nongovernmental organizations that have to face the critical challenge of vaccinating the largest number of people in the shortest time. This study aims to provide an easy tool for minimizing the duration of mass vaccination campaigns in rural and remote areas of developing countries.

Design/methodology/approach
This paper presents a linear mathematical model that combines location, scheduling and routing decisions that allows determining where to locate the vaccination centers, as well as the schedule/route that each medical team must follow to meet the target demand in the shortest time possible. In addition, the paper proposes an heuristic approach that can be integrated in a spreadsheet.

Findings
As the numerical experiments show, the proposed heuristic provides good solutions in a short time. Due to its simplicity and flexibility, the proposed approach allows decision-makers to analyze and evaluate several possible scenarios for decision-making by simply playing with input parameters.

Social implications
The integration of the heuristic approach in a spreadsheet provides a simple and efficient tool to help decision-makers while avoiding the need for large investments in information systems infrastructure by user organizations.

Originality/value
Motivated by a real-life problem and different from previous studies, the objective of the planning is to reduce the length of the vaccination campaigns with the available resources and ensure a target coverage instead of planning for minimizing costs or maximizing coverage. Furthermore, for helping implementation to practitioners, the heuristic can be solved in a spreadsheet.
Investigating the key drivers of client affiliation to Islamic banking in Oman
Authors: Abdel-Gadir Sufian , Billah Muhammad Masum 
Published: July 2024

Purpose
The purpose of this study to explore the perception, satisfaction, awareness and attitude levels of clients towards Islamic banking in Oman. By recognizing the elements affecting client affiliation with Islamic banks, this examination means to give important experiences to further developing client commitment and fulfilment in the Islamic financial area.

Design/methodology/approach
This study embraces a quantitative methodology, using SPSS@28 programming for information investigation. Information was gathered through studies directed to clients of Islamic banks in Oman. Exploratory factory analysis (EFA) was led to distinguish key variables impacting client affiliation, and dependability examination was performed using Cronbach’s alpha.

Findings
The discoveries uncover that perception arises as the main variable impacting client connection with Islamic banks in Oman, followed intently by satisfaction and awareness. Notwithstanding, the attitude factor displayed lower unwavering quality. Factual tests affirm the vigor of the noticed patterns, featuring the significance of perception, satisfaction and awareness in driving client commitment with Islamic financial establishments.

Research limitations/implications
This study is dependent upon specific constraints, as it centres exclusively around clients’ viewpoints and does not consider the perspectives of non-clients or partners in the Islamic financial industry. Future exploration could investigate these viewpoints to give a more complete comprehension of the variables impacting client connection with Islamic banks in Oman.

Practical implications
The discoveries of this study have commonsense ramifications for Islamic financial foundations in Oman. By understanding the elements impacting client alliance, banks can foster designated methodologies to improve client commitment, fulfilment and steadfastness. This might include further developing correspondence endeavours, improving assistance quality and tending to client concerns to encourage a positive financial encounter.

Originality/value
This study adds to the current writing by giving experimental experiences into the discernments, mentalities, mindfulness and fulfilment levels of clients towards Islamic banking in Oman. The recognizable proof of key elements impacting client affiliation with Islamic banks offers important direction for banking foundations trying to reinforce their associations with clients and work on general execution in the Islamic financial area.