bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integration of Oncology and Palliative Care: A Systematic Review
Authors: Hui David , Kim Yu Jung , Park Ji Chan , Zhang Yi , Strasser Florian , Cherny Nathan , Kaasa Stein , Davis Mellar P. , Bruera Eduardo 
Published: December 2014

Abstract

Background.
Both the American Society of Clinical Oncology and the European Society for Medical Oncology strongly endorse integrating oncology and palliative care (PC); however, a global consensus on what constitutes integration is currently lacking. To better understand what integration entails, we conducted a systematic review to identify articles addressing the clinical, educational, research, and administrative indicators of integration.

Materials and Methods.
We searched Ovid MEDLINE and Ovid EMBase between 1948 and 2013. Two researchers independently reviewed each citation for inclusion and extracted the indicators related to integration. The inter-rater agreement was high (κ = 0.96, p &lt; .001).

Results.
Of the 431 publications in our initial search, 101 were included. A majority were review articles (58%) published in oncology journals (59%) and in or after 2010 (64%, p &lt; .001). A total of 55 articles (54%), 33 articles (32%), 24 articles (24%), and 14 articles (14%) discussed the role of outpatient clinics, community-based care, PC units, and inpatient consultation teams in integration, respectively. Process indicators of integration include interdisciplinary PC teams (n = 72), simultaneous care approach (n = 71), routine symptom screening (n = 25), PC guidelines (n = 33), care pathways (n = 11), and combined tumor boards (n = 10). A total of 66 articles (65%) mentioned early involvement of PC, 18 (18%) provided a specific timing, and 28 (28%) discussed referral criteria. A total of 45 articles (45%), 20 articles (20%), and 66 articles (65%) discussed 8, 4, and 9 indicators related to the educational, research, and administrative aspects of integration, respectively.

Conclusion.
Integration was a heterogeneously defined concept. Our systematic review highlighted 38 clinical, educational, research, and administrative indicators. With further refinement, these indicators may facilitate assessment of the level of integration of oncology and PC.
Several origins of floral oil in the Angelonieae, a southern hemisphere disjunct clade of Plantaginaceae
Authors: Martins Aline C. , Scherz Mark D. , Renner Susanne S. 
Published: December 2014

• Premise of the study: Over the past 75 Myr, successive groups of plants have entered the “oil bee pollination niche,” meaning that they depend on oil‐collecting bees for their pollination. The highly dissimilar numbers of plant species and bee species involved in these mutualisms imply evolutionary host switching, asymmetric mutual dependencies, and uncoupled diversification. Among the clades with the best field data on oil bee behavior is the Angelonieae, which we here investigate to better understand the evolutionary time frame of this pollination syndrome.• Methods: We generated nuclear and plastid data matrices for 56% of the Angelonieae species (plus outgroups) and used Bayesian methods of molecular clock dating, ancestral state reconstruction, and biogeographic inference.• Key results: We found that Angelonieae have two major clades, Angelonia (including Monopera) and Basistemon, and Monttea, Melosperma, and Ourisia.• Conclusions: Angelonieae date back to the Uppermost Eocene, ca. 35 (26–47) Myr ago (Ma) and diversified in dry areas of southern South America; they switched from nectar to oil as a reward four or five times over the past 25 Ma. As predicted in a previous non‐clock‐dated study, dispersal to Australasia dates to the Miocene/Pliocene.
La construction du grand électro-aimant de l’Académie des sciences
Authors: Guthleben Denis 
Published: December 2014

En 1956, le CNRS fait paraître un bel ouvrage réunissant les œuvres scientifiques du physicien Aimé Cotton1. L’initiative est soutenue sans réserve depuis le début des années 1950 par le directeur général de l’établissement, Gaston Dupouy. Elle constitue, à ses yeux, une occasion privilégiée de rendre hommage à celui qui a été son maître, son patron et, n’ayons pas peur des mots, l’idole vers laquelle il ne cesse de se tourner jusque dans les moindres occasions – Gaston Dupouy n’oublie ainsi jamais de rappeler à ses propres étudiants tout le parti qu’Aimé Cotton savait tirer « d’un capuchon de stylographe pour le réglage des miroirs de Fresnel »… Pour autant, les Œuvres scientifiques d’Aimé Cotton ne sont pas seulement l’offrande d’un élève arrivé au faîte de sa carrière à son maître. Elles traduisent l’estime de toute une communauté pour un chercheur de premier plan, un expérimentateur de génie et un homme de convictions, que la modestie a conduit à repousser cette marque de révérence jusqu’au moment où elle ne pouvait plus être exprimée qu’à titre posthume.
Functions of Heat Shock Proteins in Pathways of the Innate and Adaptive Immune System
Authors: Binder Robert Julian 
Published: December 2014

Abstract
For more than 50 years, heat shock proteins (HSPs) have been studied for their role in protecting cells from elevated temperature and other forms of stress. More recently, several roles have been ascribed to HSPs in the immune system. These include intracellular roles in Ag presentation and expression of innate receptors, as well as extracellular roles in tumor immunosurveillance and autoimmunity. Exogenously administered HSPs can elicit a variety of immune responses that have been used in immunotherapy of cancer, infectious diseases, and autoimmune disease.
The Plasmacytoid Dendritic Cell as the Swiss Army Knife of the Immune System: Molecular Regulation of Its Multifaceted Functions
Authors: Karrich Julien J. , Jachimowski Loes C. M. , Uittenbogaart Christel H. , Blom Bianca 
Published: December 2014

AbstractPlasmacytoid dendritic cells (pDC) have been regarded as the “professional type I IFN–producing cells” of the immune system following viral recognition that relies on the expression of TLR7 and TLR9. Furthermore, pDC link the innate and adaptive immune systems via cytokine production and Ag presentation. More recently, their ability to induce tolerance and cytotoxicity has been added to their “immune skills.” Such a broad range of actions, resembling the diverse functional features of a Swiss army knife, requires strong and prompt molecular regulation to prevent detrimental effects, including autoimmune pathogenesis or tumor escape. Over the last decades, we and other investigators have started to unravel some aspects of the signaling pathways that regulate the various functions of human pDC. In this article, we review aspects of the molecular regulatory mechanisms to control pDC function in light of their multifaceted roles during immunity, autoimmunity, and cancer.
Th1/Th17 Plasticity Is a Marker of Advanced β Cell Autoimmunity and Impaired Glucose Tolerance in Humans
Authors: Reinert-Hartwall Linnea , Honkanen Jarno , Salo Harri M. , Nieminen Janne K. , Luopajärvi Kristiina , Härkönen Taina , Veijola Riitta , Simell Olli , Ilonen Jorma , Peet Aleksandr , Tillmann Vallo , Knip Mikael , Vaarala Outi ,   The DIABIMMUNE Study Group, Knip Mikael , Koski Katriina , Koski Matti , Härkönen Taina , Ryhänen Samppa , Hämäläinen Anu-Maaria , Ormisson Anne , Peet Aleksandr , Tillmann Vallo , Ulich Valentina , Kuzmicheva Elena , Mokurov Sergei , Markova Svetlana , Pylova Svetlana , Isakova Marina , Shakurova Elena , Petrov Vladimir , Dorshakova Natalya V. , Karapetyan Tatyana , Varlamova Tatyana , Ilonen Jorma , Kiviniemi Minna , Alnek Kristi , Janson Helis , Uibo Raivo , Salum Tiit , von Mutius Erika , Weber Juliane , Ahlfors Helena , Kallionpää Henna , Laajala Essi , Lahesmaa Riitta , Lähdesmäki Harri , Moulder Robert , Nieminen Janne , Ruohtula Terhi , Vaarala Outi , Honkanen Hanna , Hyöty Heikki , Kondrashova Anita , Oikarinen Sami , Harmsen Hermie J. M. , De Goffau Marcus C. , Welling Gjalt , Alahuhta Kirsi , Virtanen Suvi M. 
Published: December 2014

Abstract
Upregulation of IL-17 immunity and detrimental effects of IL-17 on human islets have been implicated in human type 1 diabetes. In animal models, the plasticity of Th1/Th17 cells contributes to the development of autoimmune diabetes. In this study, we demonstrate that the upregulation of the IL-17 pathway and Th1/Th17 plasticity in peripheral blood are markers of advanced β cell autoimmunity and impaired β cell function in human type 1 diabetes. Activated Th17 immunity was observed in the late stage of preclinical diabetes in children with β cell autoimmunity and impaired glucose tolerance, but not in children with early β cell autoimmunity. We found an increased ratio of IFN-γ/IL-17 expression in Th17 cells in children with advanced β cell autoimmunity, which correlated with HbA1c and plasma glucose concentrations in an oral glucose tolerance test, and thus impaired β cell function. Low expression of Helios was seen in Th17 cells, suggesting that Th1/Th17 cells are not converted thymus-derived regulatory T cells. Our results suggest that the development of Th1/Th17 plasticity may serve as a biomarker of disease progression from β cell autoantibody positivity to type 1 diabetes. These data in human type 1 diabetes emphasize the role of Th1/Th17 plasticity as a potential contributor to tissue destruction in autoimmune conditions.
The P2X1 Receptor Is Required for Neutrophil Extravasation during Lipopolysaccharide-Induced Lethal Endotoxemia in Mice
Authors: Maître Blandine , Magnenat Stéphanie , Heim Véronique , Ravanat Catherine , Evans Richard J. , de la Salle Henri , Gachet Christian , Hechler Béatrice 
Published: December 2014

Abstract
Extracellular ATP is becoming increasingly recognized as an important regulator of inflammation. However, the known repertoire of P2 receptor subtypes responsible for the proinflammatory effects of ATP is sparse. We looked at whether the P2X1 receptor, an ATP-gated cation channel present on platelets, neutrophils, and macrophages, participates in the acute systemic inflammation provoked by LPS. Compared with wild-type (WT) mice, P2X1−/− mice displayed strongly diminished pathological responses, with dampened neutrophil accumulation in the lungs, less tissue damage, reduced activation of coagulation, and resistance to LPS-induced death. P2X1 receptor deficiency also was associated with a marked reduction in plasma levels of the main proinflammatory cytokines and chemokines induced by LPS. Interestingly, macrophages and neutrophils isolated from WT and P2X1−/− mice produced similar levels of proinflammatory cytokines when stimulated with LPS in vitro. Intravital microscopy revealed a defect in LPS-induced neutrophil emigration from cremaster venules into the tissues of P2X1−/− mice. Using adoptive transfer of immunofluorescently labeled neutrophils from WT and P2X1−/− mice into WT mice, we demonstrate that the absence of the P2X1 receptor on neutrophils was responsible for this defect. This study reveals a major role for the P2X1 receptor in LPS-induced lethal endotoxemia through its critical involvement in neutrophil emigration from venules.
IFN-γ Regulates CD8+ Memory T Cell Differentiation and Survival in Response to Weak, but Not Strong, TCR Signals
Authors: Stoycheva Diana , Deiser Katrin , Stärck Lilian , Nishanth Gopala , Schlüter Dirk , Uckert Wolfgang , Schüler Thomas 
Published: December 2014

Abstract
In response to primary Ag contact, naive mouse CD8+ T cells undergo clonal expansion and differentiate into effector T cells. After pathogen clearance, most effector T cells die, and only a small number of memory T cell precursors (TMPs) survive to form a pool of long-lived memory T cells (TMs). Although high- and low-affinity CD8+ T cell clones are recruited into the primary response, the TM pool consists mainly of high-affinity clones. It remains unclear whether the more efficient expansion of high-affinity clones and/or cell-intrinsic processes exclude low-affinity T cells from the TM pool. In this article, we show that the lack of IFN-γR signaling in CD8+ T cells promotes TM formation in response to weak, but not strong, TCR agonists. The IFN-γ–sensitive accumulation of TMs correlates with reduced mammalian target of rapamycin activation and the accumulation of long-lived CD62LhiBcl-2hiEomeshi TMPs. Reconstitution of mammalian target of rapamycin or IFN-γR signaling is sufficient to block this process. Hence, our data suggest that IFN-γR signaling actively blocks the formation of TMPs responding to weak TCR agonists, thereby promoting the accumulation of high-affinity T cells finally dominating the TM pool.
The Interaction of KIR3DL1*001 with HLA Class I Molecules Is Dependent upon Molecular Microarchitecture within the Bw4 Epitope
Authors: Saunders Philippa M. , Vivian Julian P. , Baschuk Nikola , Beddoe Travis , Widjaja Jacqueline , O’Connor Geraldine M. , Hitchen Corinne , Pymm Phillip , Andrews Daniel M. , Gras Stephanie , McVicar Daniel W. , Rossjohn Jamie , Brooks Andrew G. 
Published: December 2014

Abstract
The killer cell Ig-like receptor 3DL1 (KIR3DL1) inhibits activation of NK cells upon interaction with HLA class I molecules such as HLA-B*57:01, which contains the Bw4 epitope spanning residues 77–83 (e.g., NLRIALR), and not with HLA allomorphs that possess the Bw6 motif (e.g., HLA-B*08:01), which differ at residues 77, 80, 81, 82, and 83. Although Bw4 residues Ile80 and Arg83 directly interact with KIR3DL1*001, their precise role in determining KIR3DL1-HLA-Bw4 specificity remains unclear. Recognition of HLA-B*57:01 by either KIR3DL1+ NK cells or the NK cell line YTS transfected with KIR3DL1*001 was impaired by mutation of residues 80 and 83 of HLA-B*57:01 to the corresponding amino acids within the Bw6 motif. Conversely, the simultaneous introduction of three Bw4 residues at positions 80, 82, and 83 into HLA-B*08:01 conferred an interaction with KIR3DL1*001. Structural analysis of HLA-B*57:01, HLA-B*08:01, and mutants of each bearing substitutions at positions 80 and 83 revealed that Ile80 and Arg83 within the Bw4 motif constrain the conformation of Glu76, primarily through a salt bridge between Arg83 and Glu76. This salt bridge was absent in HLA-Bw6 molecules as well as position 83 mutants of HLA-B*57:01. Mutation of the Bw4 residue Ile80 also disrupted this salt bridge, providing further insight into the role that position 80 plays in mediating KIR3DL1 recognition. Thus, the strict conformation of HLA-Bw4 allotypes, held in place by the Glu76–Arg83 interaction, facilitates KIR3DL1 binding, whereas Bw6 allotypes present a platform on the α1 helix that is less permissive for KIR3DL1 binding.
Geven en krijgen rond het tijdschrift De Beweging (1905-1919)
Authors: van den Braber Helleke 
Published: December 2014

Abstract

Patterns of Giving and Receiving: the Case of the Cultural Magazine
De Beweging (1905-1919)

The Dutch poet Albert Verwey was editor of the cultural magazine De Beweging between 1905-1919. This article uses gift theory to investigate the alliances he forged with his publishers, with his readers, and with the writers he worked with, and takes stock of the ways he tried to keep the insolvent magazine financially afloat. Verwey struggled to find a balance between his own agenda and the interests of his associates, and had to tread carefully as he appealed to their clemency and goodwill. Following Aafke Komter, who differentiates between four types of gift relationship, this article demonstrates that Verwey positioned himself predominantly within the modes of what Komter calls community sharing and authority ranking.
Het prozagedicht in Vlaanderen en Nederland als model
Authors: de Strycker Carl , Vandevoorde Hans 
Published: December 2014

Abstract

The Prose Poem in Flanders and the Netherlands as a Model. On Genres and Generations

This article explores the ways in which the genre of the prose poem functioned as a model in Flemish and Dutch literature from the 1890’s to the 1920’s. Focusing on two cases – a prewar and a postwar one –, it is argued that the genre was reinterpreted by new literary generations and, infused with new elements, became a productive model for new texts. A first case study deals with Pol de Mont and Ellen Corr. The former modified the model as he borrowed it from the authors of the Eighties movement, and it subsequently became a productive model for an epigone like Corr. In a second case study, dealing with Herman Heijermans and Constant van Wessem, we show how the genre was modified again in the period following World War I, and was made to incorporate modern elements such as cinematic processes and a businesslike, objective form. Finally, these cases reveal that models go beyond the genre, since their evolution is often based on eye-catching features that are not necessarily essential to the definition of the genre per se.
Green-Banking Practices in Bangladesh-A Scope to Make Banking Green
Authors: Islam Md. Ariful , Hossain Kh. Fahim , Siddiqui Mahmudul Hasan , Yousuf Salahuddin 
Published: December 2014

In Bangladesh, it is not blamed to pollute environment compare with other countries. Amount of CO2 emission is also very low comparing with other countries. But we are the victims of this CO2 emission or environmental pollution. So, to survive ourselves we should incorporate this green banking for the sake of our people. As early as possible the banking community should commence its activities. Government should take necessary steps to enforce existing environmental regulations and formulate appropriate rules to ensure ―Pollute Pays Principle‖ in the country. The Central bank of Bangladesh can play a pro-active role in formulating a national level ―Green Credit Policy‖ and creating a sound incentive structure for performing ER practices by banks. Much more is expected from the civil society organizations in the form of awareness development, research activities and business monitoring. ‗Consumer Awareness‘ is the area where Bangladesh needs remarkable change, because green banking is largely driven by consumer behavior and consumption patterns. For rapid change among consumers and business, a collective endeavor of government, media, NGOs, and banks will be required. An isolated effort by banking communities may not bring much. The success of the proposed framework would depend upon the pro-active role of all stakeholders and a sound incentive structure.
Investment in Financial Derivatives Contracts from an Islamic Perspective
Authors: Mohammed Hourani Yesser Abdelkarim Karim , ZARAI Mohammed Ali 
Published: December 2014

This research aims at exploring the nature of financial derivatives (FD) and their associated activities, and thus highlight their legitimate rule from an Islamic Perspective. Although there are many kinds of financial derivatives, this research focuses on the discussion of only three basic contracts; namely options, futures and swaps contracts, because they represent financial contracts derived from financially stable instruments such as stocks and bonds. There is no doubt that the great importance of this research lies mainly in determining the nature of these contracts and knowing their legitimate rules. In dealing with this issue, the research employs a descriptive approach which relies on first clarifying the image of each contract and its contemporary concept, second explaining the contract's performance and applications in the field of financial transactions, with reference to illustrative examples, and finally discussing its legitimate rule.The research results in uncovering the legitimate ruling on financial derivatives contracts, summed up mainly in the presence of betrayal and ignorance; leading, therefore, to the prohibition of such contracts.
BACTERIA AND INFLAMMATORY RESPONSE IN THE UTERUS OF BITCHES AFTER ARTIFICIAL INSEMINATION
Authors: Ribeiro Ana Paula Coelho , Vicente Wilter Ricardo Russiano , Dos Santos Ivo Walter , Apparício Maricy Ferreira , Carareto Roberta , Pigatto Caroline Peters 
Published: December 2014

The present study aimed to obtain information about the uterine inflammatory response (number of polymorphonuclear neutrophilic granulocytes - PMNs) in bitches after artificial insemination (AI) and identify the uterine microflora present after the following treatments: insemination using semen with extender (n=6), insemination with fresh semen (n=6) and no inseminated (n=6). The percentage of PMNs on the endometrial surface and within histological sections was evaluated together with the presence of aerobic bacteria in the uterine lumen. For endometrial cytology, there was no significative difference on the number of inflammatory cells between bitches not inseminated (3.05 ± 1.74 PMNs) and those inseminated with fresh semen (3.55 ± 1.51 PMNs); There was a significative difference in both groups compared to the inseminated with semen plus extender (7.80 ± 1.67 PMNs) (p<0.05). Histology showed that there was no significative difference on the number of inflammatory cells between bitches not inseminated (87.72 ± 35.2 PMNs) and those inseminated with fresh semen (122.97 ± 43.31 PMNs); however, it was observed differences in both groups compared to those inseminated with semen plus extender (171.94 ± 42.74 PMNs) (p<0.05). Eight animals, randomly distributed in the groups, showed the presence of Staphylococcus sp and Proteus sp., in the microbiological exam. The extender for semen, with Tris, is a potent inducer of uterine inflammation, and positive uterine cultures may be obtained during estrus without inflammation or uterine infection.
PESQUISA DE ANTICORPOS CONTRA <i>Cysticercus bovis</i>, POR TESTE ELISA EM BOVINOS DE ABATEDOURO
Authors: Thomaz-Soccol Vanete , Souza Valmir Kowaleski , Pessoa Oscar Lago , Minozzo João Carlos , Pessoa-Silva Maria Carmo , Peixoto Rafaela P.M.G , Moura Juliana Ferreira 
Published: December 2014

Com o objetivo de padronizar e avaliar a campo um teste sorológico para diagnóstico de cisticercose em bovinos foram examinados 812 animais procedentes de 139 municípios do Estado do Paraná, a maioria bovinos azebuados, machos e fêmeas, de grupo etário variando de 18 meses a 60 meses. Os animais foram devidamente identificados e abatidos em frigorífico comercial na região metropolitana de Curitiba. Dos animais que apresentaram cistos durante a Inspeção post-mortem foi colhida amostra de sangue, as quais foram submetidas ao teste ELISA para pesquisa de anticorpos contra-Cysticercus bovis. O coeficiente de sensibilidade para o teste ELISA foi de 83,6% e o Coeficiente de Especificidade foi de 92,8%. Portanto, o teste sorológico (ELISA) foi mais sensível do que o exame póst-mortem, pois este deixou de detectar 06 carcaças com infecção leve por cisticercose (VPP 99,7% - ELISA).