bluuebunny/crossref_metadata_2025_split huggingface dataset:
ISCB: past–present perspective for the International Society for Computational Biology
Authors: Rost Burkhard 
Published: December 2013

Abstract
Since its establishment in 1997, International Society for Computational Biology (ISCB) has contributed importantly toward advancing the understanding of living systems through computation. The ISCB represents nearly 3000 members working in &gt;70 countries. It has doubled the number of members since 2007. At the same time, the number of meetings organized by the ISCB has increased from two in 2007 to eight in 2013, and the society has cemented many lasting alliances with regional societies and specialist groups. ISCB is ready to grow into a challenging and promising future. The progress over the past 7 years has resulted from the vision, and possibly more importantly, the passion and hard working dedication of many individuals.
Tyk2 is a therapeutic target for psoriasis-like skin inflammation
Authors: Ishizaki Masayuki , Muromoto Ryuta , Akimoto Toshihiko , Sekine Yuichi , Kon Shigeyuki , Diwan Manish , Maeda Hiroaki , Togi Sumihito , Shimoda Kazuya , Oritani Kenji , Matsuda Tadashi 
Published: December 2013

AbstractTyrosine kinase 2 (Tyk2), a member of the Jak kinase family, mediates signals triggered by various cytokines, which are related to the pathogenesis of psoriasis. In this study, we investigated the role of Tyk2 in IL-23-induced psoriasis-like skin inflammation. Tyk2−/− mice when injected with IL-23 showed significantly reduced ear skin swelling with epidermal hyperplasia and inflammatory cell infiltration compared with wild-type mice. In addition, Tyk2 deficiency reduced production of pro-inflammatory cytokines and psoriasis-relevant anti-microbial peptides. More noteworthy is that Tyk2 directly regulated IL-22-dependent inflammation and epidermal hyperplasia. Taken together with the inhibition of IL-23-induced inflammation by treatment with neutralizing antibodies against IL-17 or IL-22, Tyk2 participates in both IL-23 and IL-22 signal transduction to mediate psoriasis-like skin inflammation. On the basis of these findings, we demonstrated for the first time that a small-molecule Tyk2 inhibitor significantly inhibited IL-23-induced inflammation and cytokine production in the skin. These observations demonstrate the important role of Tyk2 in experimental skin inflammation and indicate the therapeutic potential of Tyk2 inhibition in human psoriasis.
First Report of Rust Caused by Pucciniastrum boehmeriae on Māmaki (Pipturus albidus) in Hawaii
Authors: Demers J. E. , McKemy J. M. , Bushe B. , Conant P. , Kumashira B. , Ko M. , Castlebury L. A. 
Published: December 2013

Pipturus albidus (Hook. & Arn.) A. Gray or māmaki is a flowering plant species in the Urticaceae (nettles) endemic to the Hawaiian Islands. Māmaki is a forest and agricultural commodity, as well as a traditional medicinal and fiber crop. In August 2013, leaf rust was observed in Kuristown, Hawaii, on 15 māmaki plants. Infected leaves had vein-delimited chlorotic spots on the adaxial surface and yellow to orange uredinia on the abaxial surface. Uredinia were scattered, minute, pulverulent, subepidermal, and dome-shaped with a central pore, consistent with Pucciniastrum. Urediniospores were 16 to 23 × 10 to 14 μm, echinulate, ellipsoid to pyriform, walls hyaline, 0.5 μm thick, contents pale yellow to bright yellow. No teliospores were observed. A voucher specimen was deposited in the U.S. National Fungus Collections (BPI 892695). The only species of Pucciniastrum previously known on Pipturus, Pucciniastrum pipturi Syd. [syn. Uredo pipturi (Syd.) Hirats. f.], has larger urediniospores, 26.5 to 40.0 × 19.5 to 27.5 μm, and is currently reported from Japan and the Philippines (3). The pathogen was identified as Pucciniastrum boehmeriae (Dietel) Syd. & P. Syd., which infects Boehmeria Jacq., also in the Urticaceae, and has urediniospores that are 18 to 27 × 13 to 18 μm and similar in shape (2). DNA was extracted from uredinial lesions and the nuclear ribosomal internal transcribed spacer (ITS2) region and the 5′ end of large subunit (28S) rDNA were amplified and sequenced following the protocol of Aime (1). The resulting fragment (GenBank Accession No. KF711854) was 100% identical to authenticated and vouchered P. boehmeriae ITS2/28S rDNA sequences (AB221449 to AB221451 and AB221391 to AB221393) (4). Sequences from P. pipturi are not available for comparison, but host family, molecular, and morphological data support the identification of the rust as P. boehmeriae, which is found throughout eastern Asia. To our knowledge, this is the first report of P. boehmeriae on māmaki and the first report in Hawaii on any host. Plant health professionals and regulatory officials can utilize this information to establish survey methods and implement appropriate management practices for this rust disease. References: (1) M. C. Aime. Mycoscience 47:112, 2006. (2) N. Hiratsuka. Revision of Taxonomy of the Pucciniastreae. Kasai Publishing and Printing, Tokyo, 1958. (3) M. Kakishima and T. Kobayashi. Mycoscience 35:125, 1994. (4) Y.-M. Liang et al. Mycoscience 47:137, 2006.
Hamilton Acute Pain Service Safety Study
Authors: Paul James E. , Buckley Norman , McLean Richard F. , Antoni Karen , Musson David , Kampf Marianne , Buckley Diane , Marcoux Michelle , Frketich Rosemary , Thabane Lehana , Cheng Ji 
Published: December 2013

Abstract

Background:
Although intravenous patient-controlled analgesia opioids and epidural analgesia offer improved analgesia for postoperative patients treated on an acute pain service, these modalities also expose patients to some risk of serious morbidity and even mortality. Root cause analysis, a process for identifying the causal factor(s) that underlie an adverse event, has the potential to identify and address system issues and thereby decrease the chance of recurrence of these complications.

Methods:
This study was designed to compare the incidence of adverse events on an acute pain service in three hospitals, before and after the introduction of a formal root cause analysis process. The “before” cohort included all patients with pain from February 2002 to July 2007. The “after” cohort included all patients with pain from January 2009 to December 2009.

Results:
A total of 35,384 patients were tracked over the 7 yr of this study. The after cohort showed significant reductions in the overall event rate (1.47 vs. 2.35% or 1 in 68 vs. 1 in 42, the rate of respiratory depression (0.41 vs. 0.71%), the rate of severe hypotension (0.78 vs. 1.34%), and the rate of patient-controlled analgesia pump programming errors (0.0 vs. 0.08%). Associated with these results, the incidence of severe pain increased from 6.5 to 10.5%. To achieve these results, 26 unique recommendations were made of which 23 being completed, 1 in progress, and 2 not completed.

Conclusions:
Formal root cause analysis was associated with an improvement in the safety of patients on a pain service. The process was effective in giving credibility to recommendations, but addressing all the action plans proved difficult with available resources.
Overexpression of an Isoprenyl Diphosphate Synthase in Spruce Leads to Unexpected Terpene Diversion Products That Function in Plant Defense
Authors: Nagel Raimund , Berasategui Aileen , Paetz Christian , Gershenzon Jonathan , Schmidt Axel 
Published: December 2013

AbstractSpruce (Picea spp.) and other conifers employ terpenoid-based oleoresin as part of their defense against herbivores and pathogens. The short-chain isoprenyl diphosphate synthases (IDS) are situated at critical branch points in terpene biosynthesis, producing the precursors of the different terpenoid classes. To determine the role of IDS and to create altered terpene phenotypes for assessing the defensive role of terpenoids, we overexpressed a bifunctional spruce IDS, a geranyl diphosphate and geranylgeranyl diphosphate synthase in white spruce (Picea glauca) saplings. While transcript level (350-fold), enzyme activity level (7-fold), and in planta geranyl diphosphate and geranylgeranyl diphosphate levels (4- to 8-fold) were significantly increased in the needles of transgenic plants, there was no increase in the major monoterpenes and diterpene acids of the resin and no change in primary isoprenoids, such as sterols, chlorophylls, and carotenoids. Instead, large amounts of geranylgeranyl fatty acid esters, known from various gymnosperm and angiosperm plant species, accumulated in needles and were shown to act defensively in reducing the performance of larvae of the nun moth (Lymantria monacha), a conifer pest in Eurasia. These results show the impact of overexpression of an IDS and the defensive role of an unexpected accumulation product of terpenoid biosynthesis with the potential for a broader function in plant protection.
An empirical study of the impact of lean construction techniques on sustainable construction in the UK
Authors: Ogunbiyi Oyedolapo , Goulding Jack Steven , Oladapo Adebayo 
Published: December 2013

Purpose– The contribution of lean construction techniques in sustainable construction cannot be over emphasised, as sustainable development is now enshrined in government policy. In addition, lean construction is now faced with the challenges of sustainable development, continuous improvement, waste elimination, a stronger user focus, increased value for money along with high quality management of projects and supply chains, and improved communications. This paper presents an exploratory study from extant literature and the results of the use of questionnaire survey among construction participants to explore the contribution of implementing lean construction techniques in sustainable construction.Design/methodology/approach– Surveys of UK-based construction professional were conducted. The data collected were analysed with SPSS 19.0 version software using the percentile method, Cronbach ' sαreliability test, Kruskal Wallis test, Kendall ' s coefficient of concordance and one samplet-test.Findings– Results from this study indicate that there are several benefits associated with implementation of lean construction and sustainable construction. The overall perspective of professionals within the construction industry, according to questionnaire survey, shows that benefits such as improved corporate image and sustainable competitive advantage, improved process flow and productivity, improvement in environmental quality and increased compliance with customer ' s expectations are realised following integration of principles of lean construction and sustainable construction within construction industry. Just-in-time, visualisation tool, value analysis, daily huddle meetings and value stream mapping are the most common lean tools/techniques for enabling sustainability. This study also identified several areas of linkage between lean and sustainability such as waste reduction, environmental management, value maximisation, and health and safety improvement among others.Originality/value– The originality of this paper lies in its consideration of lean construction principles to better understand its impact on sustainable construction. This research contributes to the awareness of the benefits that can be derived from the implementation of lean construction in sustainable construction within the construction industry.
Future perspectives on product data management in building information modeling
Authors: Palos Salla , Kiviniemi Arto , Kuusisto Johanna 
Published: December 2013

Purpose– It has been argued that product data libraries have the potential to improve global real-estate development and increase productivity. Product data libraries provide the basis to support diverse national classification systems and different languages. The aim of this paper is to identify product data management (PDM) systematics and recommend future development needs to building product libraries, focusing on the functional shortcomings and data processing deficiencies found in the current libraries.Design/methodology/approach– A literature review of state-of-the-art practices of BIM within the construction industry was conducted including product libraries, supply chains, guidelines, industry tools and practices, and general use of BIM. Findings from the literature review were complemented with insights from the academia and industry by obtaining data through focused interviews with experts who were chosen based on their prestige and reference.Findings– As a result of the studies performed for this article, roadmaps are proposed for product library implementation globally. The role of standardization in implementing BIM-compatible product libraries is highlighted.Originality/value– This article covers the state-of-the-art practices of PDM in BIM libraries, which is useful for the development of coherent BIM libraries for the AEC industry worldwide.
Integrating risk management in the innovation project
Authors: Bowers John , Khorakian Alireza 
Published: December 2013

Purpose– While innovation has many similarities to other forms of projects it is characterised by a high failure rate and the need to stimulate creativity. More explicit risk management could help in achieving success in innovation projects. However, too much or inappropriate risk management might stifle the creativity that is core to innovation. So, what project risk management should be applied and where in the innovation project?Design/methodology/approach– A theoretical framework is proposed which combines the generic innovation process with project risk management. The framework was used to analyse the current attitudes to managing innovation risk in a series of companies.Findings– The decision points of the stage-gate innovation process model provide an effective interface for incorporating project risk concepts. The general concepts appear most relevant to innovation management though it is useful to customise them to emphasise the particular characteristics of innovation projects. The experience of using the resultant combined model in a number of diverse case studies indicates the relevance of the model in understanding attitudes towards risk management in innovation. The analysis of the case study companies suggested that risk management needs to be applied in differential manner: simple, unobtrusive techniques early in the innovation life cycle with more substantial, quantitative methods being considered for later stages.Research limitations/implications– It would be useful to extend this research by examining more case studies from other countries and industries.Practical implications– The combined innovation and risk management model provides a framework that diverse companies can appreciate. The framework offers a basis for discussing the most appropriate form of risk management in different innovation-based industries.Originality/value– Although there are many separate models for innovation and project risk management described in the literature, there is very little discussion about explicitly combining these theories. This paper aims to help fill this gap in the knowledge.
Influence of risk on technology adoption: inertia strategy in the space industry
Authors: Dos Santos Paulino Victor 
Published: December 2013

Purpose– The topic of the risk associated with innovation is being investigated through the influence of technological risk on technology adoption.Design/methodology/approach– The paper analyses the dynamics of technology adoption in high technology products thanks to several regressions. The paper uses data gathered from a major European space integrator.Findings– The paper shows that a firm may implement a reliability-based inertia strategy under a specific context. This type of inertia strategy is rational and leads a firm to limit the adoption of new technologies and favours the reuse of proven technologies. This strategy is relevant to facing a risk of decrease in technical reliability.Research limitations/implications– While the space industry displays some similarities with other capital good industries, it remains specific compared to mass production industries. The current paper should be considered as a preliminary research that aims at structuring the notion of inertia strategy.Practical implications– In order to increase the commercial demand, the paper proposes that satellite manufactures adopt more intensive reliability-based inertia strategy and institutional demand asks for less experimental satellites.Originality/value– This paper contributes to show that delays in technology adoption should not systematically be regarded as a weakness. Implementing a strategy that aims at slowing down technology adoption may sometimes improve firm survival. The paper also intends to provide a new insight to the paradoxical nature of change.
Conducting case study research in non-profit organisations
Authors: Shekhar Singh Ardhendu 
Published: December 2013

Purpose
– The purpose of this paper is to focus on the transactional relationship between retailers and handicrafts suppliers using case study research.

Design/methodology/approach
– Various reports on the handicraft sector were studied. Interactions with industry experts also helped clarify various issues confronting the industry. Preliminary visits to organizations working in this area were undertaken to know the ground realities of the handicraft sector.

Findings
– To prove the reliability of the case study process and enable others to replicate it, the steps and procedures must be clearly explicit and well documented in the final report. In this research, the steps that are followed to collect the data have been described in detail so that other researchers can apply the case study process and achieve similar results.

Originality/value
– Scholarship focussing on organised retail as well as handicrafts production and marketing is well developed. There is vast literature on the former from the developed economies though the Indian context is only beginning to be researched. Similarly, there are a large number of scholarly and popular writings on the latter. Yet, there is a paucity of scholarship on the buyer-supplier transactions.
Does culture tame the bunny? A content analysis of a global adult magazine
Authors: Kusuma Meidiahna 
Published: December 2013

Purpose– Few empirical studies have probed the effects of culture on the standardization/adaptation decision in the context of controversial products. This study aims to investigate the relationship between sociosexuality and the adaptation decision for editorial images and advertisements inPlayboymagazine through content analysis.Design/methodology/approach– This study is a qualitative research using content analysis as the research approach. The content analysis is done forPlayboymagazines from four culturally diverse countries conducted for this study.Findings– The result shows that editions of the magazine across four culturally diverse countries reveal that sociosexuality is positively correlated to the degree of nudity in photographs and to the usage of advertising for controversial products. Moreover, the paper uses the concept of sociosexuality to gain a better understanding of the empirical discrepancies concerning nudity or sex appeal.Originality/value– This research is an empirical study developed by author to confirm the influence of culture on the standardization/adaptation decision in the context of controversial products. This research is originally developed by author and has not been published before.
Sustainable tourism, climate change and sea level rise adaptation policies in Barbados
Authors: Mycoo Michelle 
Published: December 2013

AbstractThe vulnerability of tourism‐dependent communities, coastal tourism facilities, and beaches to climate change demands the use of measures that can urgently minimise vulnerability and in the long term achieve sustainable development. This paper makes policy recommendations to address climate change and sea level rise challenges in small island developing states. Using Barbados as a case study, the paper found that innovations in policies and projects have offset the past ills of mass tourism and fortuitously now serve as pre‐emptive measures in adapting to climate change. The array of methods for combating these changes includes physical planning policies, integrated coastal zone management, and infrastructure projects. Among the key areas for policy innovation are the adoption of protection, accommodation, and retreat strategies, which are informed by rigorous cost‐benefit analysis and stakeholder consultation. Ecosystem‐based adaptation to climate change is also necessary, especially for islands where coral reef protection is urgent. Moreover, policy adjustments are required on building construction, water resources management, sewage treatment, coastal zone management, physical planning, and land management. Institutional constraints, including the lack of capacity to implement, monitor, and enforce measures, must also be addressed if progress is to be made in adapting to climate change. A major conclusion is that the severity of coastal damage, the importance of tourism to sustainable development, and the country's adaptive capacity play a key part in the selection and implementation of climate change adaptation measures.
First manic episode associated with use of human chorionic gonadotropin for obesity: a case report
Authors: Sanches Marsal , Pigott Teresa , Swann Alan C , Soares Jair C 
Published: December 2013

BackgroundAlthough highly controversial, the treatment of obesity with exogenous human chorionic gonadotropin (HCG) remains popular in the USA. We report the case of a patient whose first manic episode was associated with the use of HCG for weight loss.Case reportA 32‐year‐old female patient was admitted to our psychiatric inpatient unit due to a two‐week history of manic symptoms. She had no previous history of manic or hypomanic episodes and had completed a 45‐day course of sublingual HCG for weight loss immediately prior to the onset of the manic episode. The patient was treated with lithium carbonate and aripiprazole, and progressed with improvement in the symptoms.ConclusionWhile it is not possible to definitively link the HCG use to the development of mania, available evidence suggests that HCG may have a contributing role in triggering manic symptomatology.
Semiparametric analysis of linear transformation models with covariate measurement errors
Authors: Sinha Samiran , Ma Yanyuan 
Published: December 2013

SummaryWe take a semiparametric approach in fitting a linear transformation model to a right censored data when predictive variables are subject to measurement errors. We construct consistent estimating equations when repeated measurements of a surrogate of the unobserved true predictor are available. The proposed approach applies under minimal assumptions on the distributions of the true covariate or the measurement errors. We derive the asymptotic properties of the estimator and illustrate the characteristics of the estimator in finite sample performance via simulation studies. We apply the method to analyze an AIDS clinical trial data set that motivated the work.