bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementasi Perangkat Next Generation Firewall untuk Melindungi Aplikasi dari Serangan Malware
Authors: Putri Herika Andini , Tulloh Rohmat , Djibran Nazel 
Published: July 2024

Based on the rapid development of technology, which has positive and negative impacts, one of the negative impacts is data leakage, called cybercrime. This is very dangerous and causes huge losses. In addition, the most commonly found cybercrimes are malware threats, phishing, DDoS, and others. In this study, the implementation of the Paloalto firewall is carried out by configuring the firewall, as is the attack testing stage using malware such as Eicar, ransomware, Trojans, Dos, and web filtering. The results of this test aim to prevent the risk of data loss, material loss, and the paralysis of public services. And to be efficient and effective in scanning for a variety of attacks without affecting network performance. The implications of the results found are expected to solve the problem at hand perfectly. NGFW performs prevention by blocking access to malware that enters its network traffic. This research also implements NGFW, where firewall configuration is carried out, namely by creating a rule policy on the firewall. In this study, an evaluation of network performance was carried out after the implementation of NGFW and firewall configuration. The results show that the use of NGFW and rule policies on firewalls can improve network security efficiently and effectively. It is hoped that these results can overcome the paralysis of public services due to malware attacks and improve network performance.
Klasifikasi Status Stunting Balita Menggunakan Metode NaÃ¯ve Bayes Gaussian Berbasis Web
Authors: Mulyono Makmur , Budianita Elvia , Nazir Alwis , Syafria Fadhilah 
Published: July 2024

The growth and development of toddlers must get attention from parents because toddlerhood is a golden period in shaping the growth and development and intelligence of children. Stunting is a state of malnutrition in which stunted growth and development of children and this is included in chronic nutritional problems, the incidence of stunting can be seen from height that is not in accordance with age. In preventing toddlers from stunting, it is necessary to anticipate early prevention by conducting examinations at the nearest posyandu which is measured using anthropometric methods. The calculation of stunting or normal status based on anthropometric data is generally processed manually so that there is a high possibility of errors in calculating and entering data. Data mining can make classifications or predictions on the stunting status of toddlers by studying previous data patterns. NaÃ¯ve bayes is one classification method that has the advantage of high accuracy with little training data as for the attributes used in this study, namely age, gender, Early Initiation of Breastfeeding (IMD), weight, height. Based on the test results, the best average accuracy was obtained on numerical data types for age, weight, height and nominal gender attributes, Early Breastfeeding Initiation (IMD) with the highest accuracy in the 80:20 data comparison, which is 80.34% with a total of 1172 data.
Analisa Pengaruh On-Demand Service Terhadap Insurance Technology di Kota Batam Menggunakan Teori Technology Acceptance Model (TAM)
Authors: Huang Suryani , Christian Yefta , Herman Herman 
Published: July 2024

Teknologi yang canggih memungkinkan segala aktivitas dilakukan dalam waktu singkat. Salah satunya yaitu dengan adanya teknologi seperti on-demand service. Penelitian ini dilakukan untuk mengetahui pengaruh dari on-demand service terhadap insurance technology dengan menggunakan teori Technology Acceptance Model (TAM). Metode yang akan digunakan dalam menganalisa data adalah metode campuran (mixed method). Pada penggunaan mteode campuran ini, peneliti membanding hasil penelitian kuantitatif serta kualitatif. Pengumpulan data dilakukan dengan membagikan kuesioner serta melakukan wawancara kepada masyarakat kota Batam yang berumur 18-45 tahun. Berdasarkan hasil data yang didapatkan dari 385 responden serta 10 narasumber, menunjukkan bahwa dominan laki-laki berumur 24-35 tahun sudah pernah menggunakan layanan teknologi informasi. Hasil penelitian dengan menggunakan teori TAM, menunjukkan bahwa canggihnya teknologi masih belum dapat menghilangkan rasa khawatir pengguna atas resiko dari penggunaan layanan teknologi asuransi. Namun dengan adanya kemudahan, keamanan data yang dijaga, serta manfaat baik yang dapat dirasakan oleh pengguna dapat meningkatkan minat pengguna untuk menggunakan layanan teknologi asuransi tersebut.
Advancements in Lipid Nanoparticle Technologies for Precision Targeting in Therapeutic Delivery
Authors: Gao Peiyang 
Published: July 2024

<img src=” https://s3.amazonaws.com/production.scholastica/article/121633/large/prnano_1412024bg2.jpeg?1721676909”> Lipid nanoparticles (LNPs) are at the forefront of targeted therapeutic delivery, serving as an innovative platform for precisely delivering therapeutic agents directly to specific cells or tissues. Therapeutic delivery seeks to enhance drug efficacy and safety by controlling the distribution of drugs within the body, thereby minimizing off-target effects while maximizing therapeutic impact. This review delves into advancements and innovations in LNP design to achieve unprecedented targeting precision, surmount biological barriers, and diminish off-target interactions. It encom-passes exploring targeting strategies, including passive targeting that leverages the enhanced permeability and retention effect, active targeting via receptor-ligand interactions, and stimuli-responsive methodologies for the controlled release of therapeutics. With a focus on novel tar-geting techniques, including endogenous targeting and strategic de-targeting, to enhance LNP de-livery specificity and therapeutic efficacy. This review articulates the critical role of lipid com-position, nanoparticle characterization, and surface engineering in tailoring LNPs for therapeutic applications. Through evaluating the forefront of LNP technology in drug delivery and gene therapy, this review forecasts the trajectory of nanoparticle-based therapeutics, envisioning their pivotal role in the advent of personalized medicine, thereby providing a foundation for future explorations aimed at refining and optimizing LNP systems for clinical applications.
A CNN Model for ODOL Truck Detection
Authors: Arifuddin Nurul Afifah , Gusti Kharisma Wiati , Amalia Rifka Dwi 
Published: July 2024

This study developed a Convolutional Neural Network (CNN) model as one of artificial intelligence method to detect trucks experiencing over-dimension and over-loading (ODOL). The primary goal of this research is to enhance the efficiency of truck monitoring, reduce road infrastructure damage, and support the sustainability of transportation using artificial intelligence approaches. The model was trained using a dataset consisting of ODOL and non-ODOL truck images, and successfully achieved a testing accuracy of 94.23%. The confusion matrix analysis demonstrated the model's ability to classify trucks with high precision. Additional testing on truck images not included in the training or testing dataset showed the model's potential for good generalization.
Change of epidermal barrier parameters and biomechanical parameters of the skin in children with atopic dermatitis during the use of a lipid-restoring cream containing biotic complex
Authors: Zaslavsky D. V. , Taganov A. V. , Molochkov A. V. , Zaslavskaya E. D. , Belenkova Ju. B. , Klimova K. A. , Kozlova D. V. 
Published: July 2024

Emollients are an integral part of the therapy for patients with atopic dermatitis. The most effective will be the new generation of emollients – emollients plus, which normalize the skin microbiome. Their effectiveness can be assessed by determining the parameters of the epidermal barrier (hydratation, sebum level, pH) and skin elasticity.Objectives. To evaluate the effectiveness and safety of a lipid-restoring cream containing a biotic complex LE SANTI in children with atopic dermatitis.Material and methods. From August to December, 25 children (9 girls, 36 % and 16 boys, 64 %) aged from 3 to 17 years (average age 9.2 years) with atopic dermatitis participated in an observational program to evaluate the effectiveness and safety of a lipid-restoring cream LE SANTI. For 21 days, patients applied the cream twice a day, they had 6 visits, during which was collected their medical history, adverse events, physical examination, determined indicators of the epidermal barrier (hydratation, sebum content, pH), biomechanical characteristics (skin elasticity), and also severity of disease (SCORAD) and quality of life (CDLQI). At visit 6, patients were assessed for satisfaction with the use of the cream.Results. All participants of the observation program completed their participation on time. As part of the observational program, there was an increase in skin hydration and sebum level by 3 and 3.5 times, respectively, pH level turned to the acidic values by 18%, an increase in elasticity by 30%, a decrease in SCORAD and CDLQI indices by 1.9 times or more 3 times respectively. The patients did not experience any adverse events; the satisfaction rating from the use of the cream was 4.78/5.Conclusions. Lipid-restoring cream LE SANTI can be recommended for inclusion in the treatment regimen for atopic dermatitis as a basic external agent that meets all the requirements for effectiveness and safety for children with atopic dermatitis, as well as basic care during remission.
Efficacy of modern methods for assessing the severity of alopecia areata
Authors: Matushevskaya E. V. 
Published: July 2024

Purpose of the study. To evaluate the effectiveness of the standardized SALT scale to determine the severity of AA patients.Materials and methods. A one-time retrospective cohort study was conducted. There were 40 patients with AA under supervision. The gender distribution of the patients was as follows: 15 men (36.6%) and 25 (63.3%) women. The average age was 29.4 years in the 18–54 age range.Results. The AA debut varied widely in age range from 2 to 45 years. The average age at which the pathological process began was 18,2±4,4 years. 22.4% of patients with a scalp hair area of more than 25%, as well as hair loss in other areas of the body and changes in the nail.The beginning of AA is fixed to 10 years. More than two relapses occurred in 54.5% of patients with scalp hair lesions of more than 25% and only 9.2% of cases with foetal AA.The following clinical forms were diagnosed: foetal (12 patients), lenticular (ophiasis, inversive ophiasis) (7 patients), multi-focal (11 patients), total and universal (10 patients). According to the SBN Hair Loss State scale, S1 clinically corresponded to focal alopecia, S2 -S4 – ophazis, multi-focal alopecia, S5 – TA and UA. Partial or complete hair loss has been noted in these areas in 38% of patients with S2-S3 and 67% with S4-S5 clinical forms. The combination of different degrees of body hair loss and dystrophy of nail plates in examined AA patients was observed in 25% of cases.Conclusion. In determining the severity of alopecia nest principally not only the size and number of lesions on the skin scalp, but also the nature of hair loss on the skin of the eyebrows and eyelashes, as well as the possible combination of hair loss and dystrophic altered nail plates, which is considered an option for a more severe course of the disease. The SBN system effectively evaluates and describes the clinical variant of AA according to a standardized scale, which can help determine clinical management of patients with different manifestations, as well as predict the course of the disease.
Itch prevalence analysis and its characteristics among acne patients
Authors: Lvov A. N. , Sidorenko E. E. , Sidorenko O. A. 
Published: July 2024

Introduction. Acne is a multifactorial chronic inflammatory disease of the pilosebaceous follicle, which manifests itself as open and closed comedones, papules, pustules and nodules.Purpose of the study. Studying of itch prevalence among patients with acne, as well as assessing its impact on their quality of life and psychoemotional status.Materials and methods. Under observation were 249 patients diagnosed with acne aged from 12 to 50 years, of which 143 women (57.4%), 106 men (42.6%). Patients were diagnosed based on complaints, anamnesis and clinical picture of the disease. To assess the impact of itching on the quality of life, the Acne Psychological and Social Effect Scale (APSEA), the Dermatological Life Quality Index (DLQI), the Cardiff Social Disadaptation Index (CADI), the Rosenberg self-esteem scale, and a self-developed questionnaire were used to assess the impact of itching on the quality of life. Questionnaire, YOUR itch.Results. To solve these problems, based on the criteria for inclusion, non-inclusion and exclusion, two clinical comparison groups were formed, comparable in terms of main clinical diagnostic indicators. The first group consisted of patients with itching due to acne (64 people, 26% of subjects), the second group consisted of patients with no itching (185 people, 74% of subjects). According to the results of the study, a statistically significant relationship between the presence of itching in acne and age, gender, the presence of obesity, impaired carbohydrate tolerance, iron deficiency anemia, hyperprolactinemia was revealed, various characteristics of itching in the subjects were described, and a close correlation of the indicators of the indices used was revealed.Conclusions. Studying the prevalence of itching in acne is a relevant area and allows us to expand our understanding of the role of subjective sensations in the development of acne and further evaluate the impact of this dermatosis on the quality of life of patients.
Comparative characteristics of the effectiveness of drugs for the treatment of alopecia areata in childhood
Authors: Murashkin N. N. , Dogov A. M. 
Published: July 2024

Alopecia areata (АА) is an autoimmune inflammatory disease with an established genetic predisposition, which is based on the lesion of hair follicles, leading to persistent or temporary hair loss. To date, treatment of АA in children, is limited to the use in most cases of external hormonal therapy in the form сream or the prescription of intradermal injections of GCS in outpatient conditions. However, data on the effectiveness of this group of drugs in severe forms of AA flow are not fully studied. There is an open question of the choice of the most preferred drug in patients simultaneously with a severe flow of AA and a severe form of atopic dermatitis. Another interesting variant of treatment of AA is the drug Dupilumab. (blocker IL-4 and IL-13). The mechanism of action of dupilumab at АA remains unknown, and its effect on TH-type 2 is assumed.Purpose of the study. To conduct a comparative performance characterization of: external GCS (Clobetazole) and injectable GCS (Betamethazone) for treatment of AA in children; Tofacitinib treatment for children with alopecia and the presence or absence of atopic dermatitis in the form of a concomitant disease; use of Dupilumaba to treat children with AA.Materials and methods. The research sample includes 420 patients. By the nature of the lesion, we considered three types of alopecia: spotted, total and universal. Patient data is taken from the register of AA patients in children. [13]. The effectiveness of the treatment was assessed on the scale SALT [14]. Patients were monitored for six months.Results. Use of intradermal injections GKS (Betamethazone), more effective than outdoor GKS (Clobetazole). In patients with atopic dermatitis, the efficacy of Tofacitinib for AA treatment is reliably higher than in patients without atopic dermatitis. Dupilumab may be a drug of choice for treating patients with a total and universal form of AA.Conclusion. Additional randomized controlled trials are needed to assess the long-term efficacy of drugs such as Tofacitinib and Dupilumab.
Laser technologies in the treatment of patients with a combination of rosacea subtypes: comparative data
Authors: Rodina A. L. , Matushevskaya Yu. I. , Sofinskaya G. V. 
Published: July 2024

Phototechnologies occupy a leading position in the treatment of patients with rosacea. The most effective technologies are laser: pulsed dye laser (585nm, 595nm) and neodymium laser (1064nm), however, issues of comparative analysis, including in patients with a combination of rosacea subtypes, require further study.Material and methods. We observed 64 patients with diagnosed rosacea with a combination of subtypes: erythematotelangiectatic and papulopustular. Among them, 48 (75%) were female and 16 (25%) were male. The age of the patients varied widely: from 31 to 57 years, the average age was 39.2±4.6 years. The average duration of the disease was 5.1±2.3 years. Depending on the therapy, patients were divided into 2 groups: group 1 received treatment with a neodymium laser, group 2 – treatment with a pulsed dye laser.Research results. A cumulative assessment taking into account clinical research methods with a sufficient degree of reliability revealed the advantages of a neodymium laser over a pulsed dye laser, regardless of the clinical picture of rosacea, which was confirmed by the dynamics of the IGA/PGA indices: reduction in group 1 was 79.5%/66.7%, in group 2–63.2%/51.3%, respectively. These data were confirmed by the dynamics of the DIQI index – 81.7% and 61.6%, respectively.
Is intraoperative parathyroid monitoring during minimally invasive parathyroidectomy still justified?
Authors: Hargitai Lindsay , Boryshchuk Daniela , Arikan Melisa , Binter Teresa , Scheuba Christian , Riss Philipp 
Published: July 2024

IntroductionPrimary hyperparathyroidism (PHPT) is the third most common endocrine disease. With parathyroidectomy, a cure rate of over 95% at initial surgery is reported. Localization of the abnormal parathyroid gland is critical for the operation to be successful. The aim of this study is to analyze data of patients with single gland disease (SGD) and positive concordant localization imaging undergoing minimally invasive parathyroidectomy (MIP) and intraoperative parathyroid hormone monitoring (IOPTH) to evaluate if IOPTH is still justified in patients with localized SGD.MethodsA retrospective database analysis of all minimally invasive operations with IOPTH for PHPT and positive concordant localization in ultrasound (US) and 99mTc-sestamibi scintigraphy (MIBI) between 2016-2021. When both US and MIBI were negative, patients underwent either choline or methionine PET-CT. The patients were also analyzed a second time without applying IOPTH.ResultsIn total, 198 patients were included in the study. The sensitivity of US, MIBI and PET-CT was 96%, 94% and 100%, respectively. Positive predictive value was 88%, 89% and 94% with US, MIBI and PET-CT, respectively. IOPTH was true positive in 185 (93.4%) patients. In 13 (6.6%) patients, no adequate IOPTH decline was observed after localizing and extirpating the assumed enlarged parathyroid gland. Without IOPTH, the cure rate decreased from 195 (98.5%) to 182 (92%) patients and the rate of persisting disease increased from 2 (1.0%) to 15 (7.5%) patients.ConclusionDiscontinuing IOPTH significantly increases the persistence rate by a factor of 7.5 in patients with concordantly localized adenoma. Therefore, IOPTH appears to remain necessary even for this group of patients.
Clinical features and prognosis of patients with anti-GBM disease combined with mesangial IgA deposition
Authors: Ning Wei , Zhao Ya-fei , Liu Ya-ru , Qi Yuan-yuan , Zhao Zhan-zheng 
Published: July 2024

IntroductionAnti-GBM diseases with IgA deposition in the mesangial region are rarely described.The factors influencing renal prognosis in patients with anti-GBM disease combined with mesangial IgA deposition are unknown.MethodsWe searched the pathological reports of the First Affiliated Hospital of Zhengzhou University from 2015 to 2023 and found that a total of 72 patients with the anti-GBM disease and 25 patients combined with mesangial IgA deposition. We studied the clinical and pathological features, renal prognosis, and the factors affecting renal prognosis in patients with anti-GBM disease combined with mesangial IgA deposition.ResultsTheir median age was 44 years, and their age distribution was unimodal. The proportion of oliguria or anuria in patients with anti-GBM disease combined with mesangial IgA deposition was significantly lower than that in patients with classic anti-GBM disease (13.04 vs. 42.31%, p=0.030). Their 24-hour urinary protein excretion was significantly higher [median:3.25 vs. 1.12g/24h, Interquartile range(IQR):1.032~3.945 vs. 0.63~1.79g/24h, p=0.020], serum creatinine (SCr) level at the initial diagnosis was lower(median:456.0 vs. 825.5μmol/L, IQR:270.0~702.0 vs. 515.8~1231.2μmol/L, p=0.002), peak SCr level was lower (median: 601.0 vs. 907.2μmol/L, IQR: 376.5~937.0 vs. 607.0~1361.2μmol/L, p=0.007), and their serum complement 3(C3) level was higher(median: 1.275 vs. 1.015g/L, IQR:1.097~1.462 vs. 0.850~1.220g/L, p=0.027). They had better renal outcomes during follow-up (p&lt;0.001). After adjustment for hypertension, oliguria or anuria, and crescents%, IgA deposition in the mesangial region was still an independent protective factor (p=0.003) for ESRD in anti-GBM patients. Hypertension (p=0.026) and SCr levels at initial diagnosis (p=0.004) were risk factors for renal prognosis in patients with anti-GBM disease combined with mesangial IgA deposition.DiscussionPatients with anti-GBM disease combined with mesangial IgA deposition have less severe renal impairment and better renal prognosis than patients with classic anti-GBM disease.