bluuebunny/crossref_metadata_2025_split huggingface dataset:
FKS subtraction for quarkonium production at NLO
Authors: A H Ajjath , Shao Hua-Sheng , Simon Lukas 
Published: July 2024

Abstract
We extend the local infrared-divergence subtraction formalism, originally proposed by Frixione, Kunszt and Signer (FKS), to calculate short-distance (differential) cross section for any inclusive process involving a quarkonium particle in non-relativistic QCD (NRQCD) factorisation at next-to-leading order (NLO) accuracy in the strong coupling constant αs. The new formulas are generally applicable to the production of an S- or P-wave quarkonium state in association with any number of elementary particles. The main new ingredients derived in this paper are the local and integrated soft counterterms for the colour-singlet and colour-octet P-wave bound states. It, therefore, paves the way to the automation of the NLO calculations for heavy quarkonium inclusive and associated production processes.
Massive carrollian fields at timelike infinity
Authors: Have Emil , Nguyen Kevin , Prohazka Stefan , Salzer Jakob 
Published: July 2024

Abstract
Motivated by flat space holography, we demonstrate that massive spin-s fields in Minkowski space near timelike infinity are massive carrollian fields on the carrollian counterpart of anti-de Sitter space called Ti. Its isometries form the Poincaré group, and we construct the carrollian spin-s fields using the method of induced representations. We provide a dictionary between massive carrollian fields on Ti and massive fields in Minkowski space, as well as to fields in the conformal primary basis used in celestial holography. We show that the symmetries of the carrollian structure naturally account for the BMS charges underlying the soft graviton theorem. Finally, we initiate a discussion of the correspondence between massive scattering amplitudes and carrollian correlation functions on Ti, and introduce physical definitions of detector operators using a suitable notion of conserved carrollian energy-momentum tensor.
Stringy constraints on primordial electromagnetic fields in axion inflation
Authors: Otsuka Hajime , Yokokura Ryo 
Published: July 2024

Abstract
We study primordial electromagnetic fields in effective actions of string theory. In contrast to a conventional scenario of producing primordial electromagnetic fields induced by the axion inflation, we deal with the Dirac-Born-Infeld action as a non-linear generation of Maxwell theory. It turns out that the intensity of generated electromagnetic fields is bounded from above by the string scale which can also be rewritten in terms of supersymmetry breaking scale in the context of type IIB Large Volume Scenario. The instability parameter ξ is constrained by the tadpole cancellation condition of D3-branes and a realization of hierarchy between the string scale and the Hubble scale of inflation. Hence, the magnetogenesis can be realized in the limited corner of the string landscape due to the $$ \mathcal{O} $$
O
(1) value of the coefficient of Chern-Simons coupling.
Open-closed string duality, branes, and topological recursion
Authors: Lowenstein Ashton 
Published: July 2024

Abstract
We consider matrix models exhibiting open-closed string duality in two-dimensional string theories with various amounts of supersymmetry. In particular, a relationship between matrix models in the β = 2 Wigner-Dyson class and models in the (1 + 2Γ, 2) Altland-Zirnbauer class relates the perturbative solutions of the two systems’ string equations. Point-like operator insertions in the closed string theory are mapped to the topological expansion of the free energy in the open string theory. We compute correlation functions of macroscopic loop operators and FZZT branes in a general topological gravity background. The relationship between the topological recursion of moduli space volumes and branes is discussed by analyzing the Virasoro conditions in the matrix models.
Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis
Authors: Li Jianming , Sun Jingxuan , Xu Mingyi , Yang Lei , Yang Ning , Deng Jingui , Ma Yanping , Qi Ying , Liu Zhongyang , Ruan Qiang , Liu Yao , Huang Yujing 
Published: July 2024

AbstractCongenital human cytomegalovirus (HCMV) infection is a major cause of abnormalities and disorders in the central nervous system (CNS) and/or the peripheral nervous system (PNS). However, the complete pathogenesis of neural differentiation disorders caused by HCMV infection remains to be fully elucidated. Stem cells from human exfoliated deciduous teeth (SHEDs) are mesenchymal stem cells (MSCs) with a high proliferation and neurogenic differentiation capacity. Since SHEDs originate from the neural crest of the early embryonic ectoderm, SHEDs were hypothesized to serve as a promising cell line for investigating the pathogenesis of neural differentiation disorders in the PNS caused by congenital HCMV infection. In this work, SHEDs were demonstrated to be fully permissive to HCMV infection and the virus was able to complete its life cycle in SHEDs. Under neurogenic inductive conditions, HCMV infection of SHEDs caused an abnormal neural morphology. The expression of stem/neural cell markers was also disturbed by HCMV infection. The impairment of neural differentiation was mainly due to a reduction of intracellular cholesterol levels caused by HCMV infection. Sterol regulatory element binding protein-2 (SREBP2) is a critical transcription regulator that guides cholesterol synthesis. HCMV infection was shown to hinder the migration of SREBP2 into nucleus and resulted in perinuclear aggregations of SREBP2 during neural differentiation. Our findings provide new insights into the prevention and treatment of nervous system diseases caused by congenital HCMV infection.
Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation
Authors: Hernández-Hernández Irene , De La Rosa Juan V. , Martín-Rodríguez Patricia , Díaz-Sarmiento Mercedes , Recio Carlota , Guerra Borja , Fernández-Pérez Leandro , León Theresa E. , Torres Rosa , Font-Díaz Joan , Roig Angela , de Mora Fernando , Boscá Lisardo , Díaz Mario , Valledor Annabel F. , Castrillo Antonio , Tabraue Carlos 
Published: July 2024

AbstractLung type 2 pneumocytes (T2Ps) and alveolar macrophages (AMs) play crucial roles in the synthesis, recycling and catabolism of surfactant material, a lipid/protein fluid essential for respiratory function. The liver X receptors (LXR), LXRα and LXRβ, are transcription factors important for lipid metabolism and inflammation. While LXR activation exerts anti-inflammatory actions in lung injury caused by lipopolysaccharide (LPS) and other inflammatory stimuli, the full extent of the endogenous LXR transcriptional activity in pulmonary homeostasis is incompletely understood. Here, using mice lacking LXRα and LXRβ as experimental models, we describe how the loss of LXRs causes pulmonary lipidosis, pulmonary congestion, fibrosis and chronic inflammation due to defective de novo synthesis and recycling of surfactant material by T2Ps and defective phagocytosis and degradation of excess surfactant by AMs. LXR-deficient T2Ps display aberrant lamellar bodies and decreased expression of genes encoding for surfactant proteins and enzymes involved in cholesterol, fatty acids, and phospholipid metabolism. Moreover, LXR-deficient lungs accumulate foamy AMs with aberrant expression of cholesterol and phospholipid metabolism genes. Using a house dust mite aeroallergen-induced mouse model of asthma, we show that LXR-deficient mice exhibit a more pronounced airway reactivity to a methacholine challenge and greater pulmonary infiltration, indicating an altered physiology of LXR-deficient lungs. Moreover, pretreatment with LXR agonists ameliorated the airway reactivity in WT mice sensitized to house dust mite extracts, confirming that LXR plays an important role in lung physiology and suggesting that agonist pharmacology could be used to treat inflammatory lung diseases.
Graphical Abstract
Lhx4 surpasses its paralog Lhx3 in promoting the differentiation of spinal V2a interneurons
Authors: Renaux Estelle , Baudouin Charlotte , Marchese Damien , Clovis Yoanne , Lee Soo-Kyung , Gofflot Françoise , Rezsohazy René , Clotman Frédéric 
Published: July 2024

AbstractParalog factors are considered to ensure the robustness of biological processes by providing redundant activity in cells where they are co-expressed. However, the specific contribution of each factor is frequently underestimated. In the developing spinal cord, multiple families of transcription factors successively contribute to differentiate an initially homogenous population of neural progenitors into a myriad of neuronal subsets with distinct molecular, morphological, and functional characteristics. The LIM-homeodomain transcription factors Lhx3, Lhx4, Isl1 and Isl2 promote the segregation and differentiation of spinal motor neurons and V2 interneurons. Based on their high sequence identity and their similar distribution, the Lhx3 and Lhx4 paralogs are considered to contribute similarly to these processes. However, the specific contribution of Lhx4 has never been studied. Here, we provide evidence that Lhx3 and Lhx4 are present in the same cell populations during spinal cord development. Similarly to Lhx3, Lhx4 can form multiproteic complexes with Isl1 or Isl2 and the nuclear LIM interactor NLI. Lhx4 can stimulate a V2-specific enhancer more efficiently than Lhx3 and surpasses Lhx3 in promoting the differentiation of V2a interneurons in chicken embryo electroporation experiments. Finally, Lhx4 inactivation in mice results in alterations of differentiation of the V2a subpopulation, but not of motor neuron production, suggesting that Lhx4 plays unique roles in V2a differentiation that are not compensated by the presence of Lhx3. Thus, Lhx4 could be the major LIM-HD factor involved in V2a interneuron differentiation during spinal cord development and should be considered for in vitro differentiation of spinal neuronal populations.
Unconventional posttranslational modification in innate immunity
Authors: Chen Jiaxi , Qi Dejun , Hu Haorui , Wang Xiaojian , Lin Wenlong 
Published: July 2024

AbstractPattern recognition receptors (PRRs) play a crucial role in innate immunity, and a complex network tightly controls their signaling cascades to maintain immune homeostasis. Within the modification network, posttranslational modifications (PTMs) are at the core of signaling cascades. Conventional PTMs, which include phosphorylation and ubiquitination, have been extensively studied. The regulatory role of unconventional PTMs, involving unanchored ubiquitination, ISGylation, SUMOylation, NEDDylation, methylation, acetylation, palmitoylation, glycosylation, and myristylation, in the modulation of innate immune signaling pathways has been increasingly investigated. This comprehensive review delves into the emerging field of unconventional PTMs and highlights their pivotal role in innate immunity.
Plakophilin 4 controls the spatio-temporal activity of RhoA at adherens junctions to promote cortical actin ring formation and tissue tension
Authors: Müller Lisa , Keil René , Glaß Markus , Hatzfeld Mechthild 
Published: July 2024

AbstractPlakophilin 4 (PKP4) is a component of cell–cell junctions that regulates intercellular adhesion and Rho-signaling during cytokinesis with an unknown function during epidermal differentiation. Here we show that keratinocytes lacking PKP4 fail to develop a cortical actin ring, preventing adherens junction maturation and generation of tissue tension. Instead, PKP4-depleted cells display increased stress fibers. PKP4-dependent RhoA localization at AJs was required to activate a RhoA-ROCK2-MLCK-MLC2 axis and organize actin into a cortical ring. AJ-associated PKP4 provided a scaffold for the Rho activator ARHGEF2 and the RhoA effectors MLCK and MLC2, facilitating the spatio-temporal activation of RhoA signaling at cell junctions to allow cortical ring formation and actomyosin contraction. In contrast, association of PKP4 with the Rho suppressor ARHGAP23 reduced ARHGAP23 binding to RhoA which prevented RhoA activation in the cytoplasm and stress fiber formation. These data identify PKP4 as an AJ component that transduces mechanical signals into cytoskeletal organization.
Changes in subjective well-being and stress of older adults before, during and after the COVID-19 pandemic: a longitudinal study in Switzerland
Authors: Valérie-Anne Ryser , Dawid Gondek , Marieke Voorpostel 
Published: July 2024

Abstract

Purpose
Despite the concerns about older adults’ overall quality of life during the COVID-19 pandemic, they often demonstrated better resilience, adaptability, and subjective well-being (SWB) than younger individuals. However, longer-term trends remain unclear. This study aims to describe older adults' trajectories in SWB dimensions before, during, and after the pandemic spanning 2017–2022.

Methods
This study used piecewise growth curve analysis on a subsample of the Swiss Household Panel to investigate the population-average (n individuals = 3086; n = observations = 13,780) trajectories of SWB dimensions and stress among adults aged 65 and older between 2017 and 2022. We also tested whether these trajectories differed by age, gender, and household income.

Results
Life satisfaction and positive affect remained stable among older people during the pandemic (2019–2021) but declined after. Negative affect increased during the pandemic and decreased afterward, while stress levels increased slightly before and significantly after the pandemic. The trajectories did not differ by gender or household income, but the oldest-old (> 75-year-old) had a more significant decline in positive affect and life satisfaction pre-pandemic (2017–2019) and stress during the pandemic (2020–2021).

Conclusion
Research shows that older adults possess adaptation skills and emotional competencies, which enable them to navigate pandemic challenges. However, we show that the post-pandemic era presents more substantial challenges for this older population, who perhaps face more difficulties adapting to the new uncertain post-pandemic world. Further research needs to examine if these findings replicate in other contexts, for instance, where pandemic containment measures have been more stringent.
Virtualism: how AI replaces reality
Authors: Söffner Jan 
Published: July 2024

AbstractThis paper traces the shift from the age of realism to the age of virtualism we are currently witnessing. To do so, I draw on older theories announcing this advent (mostly Baudrillard in Simulacra and simulation. Transl. Sheila Glaser. University of Michigan, Ann Arbor, 1994 [1981]; Serres in Atlas. Édition Julliard, Paris, 1994; Virilio in The vision machine. Transl. Rose J. Indiana UP, Bloomington, 1994). I will describe how AI destabilizes fundamental distinctions upon which reality is built—such as the difference between truth and fiction, between existence and simulation, between the actual and the potential, between game and everyday life, between person and avatar. Against the backdrop of a broader notion of the virtual (drawing on Deleuze in The actual and the virtual. Transl. Eliot Ross Albert in Parnet C Dialogues. Bloomsbury, London, pp 148–152, 2006 [1996]), I will read current realist theories (Chalmers in Reality plus—virtual worlds and the problems of philosophy. Allen Lane, London in 2022; Gabriel in Why the world does not exist. Transl. Gregory S. Moss. Polity, Cambridge, 2015; Ferraris in Positive realism. Zero Books, Arlesford, 2015; Meillassoux in After finitude—an essay on the necessity of contingency. Transl. Brassler R. Bloomsbury, London, 2008) as symptoms of the ongoing shift (rather than countermeasures against it), because they result in an inability to do justice to the epistemic and existential changes resulting from the erosion of the foundations of reality. The consequences of this shift are hard to predict and can only partially be outlined in this paper, which will end in a cautious attempt to do so (chapters 5 and 6). Starting off with a brief overview on this topic (chapter 1), I will trace the reasons for my diagnosis focusing first on what I call the “age of reality” currently coming to an end (chapter 2), then on why virtuality cannot be subsumed under reality (chapter 3), then how virtuality is currently replacing reality (chapter 4).
University expansion and female adolescents’ educational attainment in Ethiopia
Authors: Ahmed Musa Hasen 
Published: July 2024

AbstractAlthough it is widely recognized that accounting for spillovers from higher education institutions is essential when formulating educational policy, research on these effects in developing countries is scarce. This study examines the spillover effects of Ethiopia's recent public university expansion program on the educational attainment of female adolescents in the surrounding areas. Employing an event study framework, the research demonstrates a positive association between the presence of a university in the neighborhood and the academic achievement of female students at lower educational levels.
How to fight fake papers: a review on important information sources and steps towards solution of the problem
Authors: Wittau Jonathan , Seifert Roland 
Published: July 2024

AbstractScientific fake papers, containing manipulated or completely fabricated data, are a problem that has reached dramatic dimensions. Companies known as paper mills (or more bluntly as “criminal science publishing gangs”) produce and sell such fake papers on a large scale. The main drivers of the fake paper flood are the pressure in academic systems and (monetary) incentives to publish in respected scientific journals and sometimes the personal desire for increased “prestige.” Published fake papers cause substantial scientific, economic, and social damage. There are numerous information sources that deal with this topic from different points of view. This review aims to provide an overview of these information sources until June 2024. Much more original research with larger datasets is needed, for example on the extent and impact of the fake paper problem and especially on how to detect them, as many findings are based more on small datasets, anecdotal evidence, and assumptions. A long-term solution would be to overcome the mantra of publication metrics for evaluating scientists in academia.
Sperm-Specific CatSper is Not Conserved in All Vertebrates and May Not be the Only Progesterone-Responsive Ion Channel Present in Sperm
Authors: Dubey Nishant Kumar , Kumar Vikash , Goswami Chandan 
Published: July 2024

AbstractProgesterone (P4) acts as a key conserved signalling molecule in vertebrate reproduction. P4 is especially important for mature sperm physiology and subsequent reproductive success. “CatSpermasome”, a multi-unit molecular complex, has been suggested to be the main if not the only P4-responsive atypical Ca2+-ion channel present in mature sperm. Altogether, here we analyse the protein sequences of CatSper1-4 from more than 500 vertebrates ranging from early fishes to humans. CatSper1 becomes longer in mammals due to sequence gain mainly at the N-terminus. Overall the conservation of full-length CatSper1-4 as well as the individual TM regions remain low. The lipid-water-interface residues (i.e. a 5 amino acid stretch sequence present on both sides of each TM region) also remain highly diverged. No specific patterns of amino acid distributions were observed. The total frequency of positively charged, negatively charged or their ratios do not follow in any specific pattern. Similarly, the frequency of total hydrophobic, total hydrophilic residues or even their ratios remain random and do not follow any specific pattern. We noted that the CatSper1-4 genes are missing in amphibians and the CatSper1 gene is missing in birds. The high variability of CatSper1-4 and gene-loss in certain clades indicate that the “CatSpermasome” is not the only P4-responsive ion channel. Data indicate that the molecular evolution of CatSper is mostly guided by diverse hydrophobic ligands rather than only P4. The comparative data also suggest possibilities of other Ca2+-channel/s in vertebrate sperm that can also respond to P4.
Graphical Abstract
In birds, only CatSper1 is absent. Similarly, in amphibians, all the CatSper units are absent, suggesting the presence of other proteins that can act as P4-responsive Ca2+-ion channels there. TRPV4 is present in all these vertebrate groups and multiple copies of the TRPV4 gene are present in amphibians
Exploring the thalamus L-sign: initial findings and associations with white matter injury in premature infants
Authors: Merhav Goni , Ravid Sarit , Shapira Rootman Mika 
Published: July 2024

Abstract
Background
The thalamus L-sign, characterized by damage to the lateral and posterior parts of the thalamus, has recently been identified as a potential marker of partial prolonged hypoxic-ischemic injury (HII). Although prematurity-related thalamic injury is well documented, its association with the thalamus L-sign is infrequently described.

Objective
The primary objective of this study was to further investigate the thalamus L-sign in premature birth and white matter injury.

Materials and methods
A retrospective analysis of 246 brain magnetic resonance imaging (MRI) scans from preterm infants born before 37 weeks of gestation was conducted to explore the occurrence, characteristics, and associations of the thalamus L-sign with white matter injury.

Results
The L-sign was detected in 12.6% of patients with periventricular leukomalacia (PVL), primarily in severe cases (57.9% of severe PVL). All cases were associated with posterior parieto-occipital PVL. Four patients exhibited unilateral or asymmetric L-signs, which were linked to high-grade intraventricular hemorrhage (IVH) or periventricular hemorrhagic infarction on the ipsilateral side, with the most severe white matter injury occurring on that side. No significant differences were observed regarding gestational age at birth, duration of neonatal intensive care unit hospitalization, percentage of IVH, hypoglycemia, or jaundice between patients with moderate-to-severe PVL with and without the thalamus L-sign.

Conclusion
The thalamus L-sign may serve as a marker for severe parieto-occipital PVL and may be exacerbated and appear asymmetric in cases of ipsilateral IVH or periventricular hemorrhagic infarction.

Graphical Abstract