bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombin Generation Assay in Hospitalized Nonsurgical Patients
Authors: Espitia Olivier , Fouassier Marc , Hardouin Jean-Benoît , Pistorius Marc-Antoine , Agard Christian , Planchon Bernard , Trossaert Marc , Pottier Pierre 
Published: August 2015

Background: Assessment of venous thromboembolism (VTE) risk is important to determine optimal primary prophylaxis in hospitalized patients. The Padua score helps to recognize patients with high VTE risk, but quantifying a VTE risk is often challenging in medical patients. Thrombin generation assay (TGA) reflects the pro-/anticoagulant balance and thus could help to better quantify VTE risk in medical hospitalized patients. Aim: To analyze the relation between TGA and VTE risk according to Padua score in medical hospitalized patients. Methods: Between May and October 2013, 105 patients were included in an unselected cohort group of patients admitted to an internal medicine department in a large, university hospital. Within the 36 hours after admission and before any anticoagulant therapy, Padua score was calculated and sample for TGA was collected for each patient. Thrombin generation assay (velocity, peak, and endogenous thrombin potential [ETP]) was performed with 1 and 5 picomol/l (pM) tissue factor (TF) reagent. Results: In patients with high Padua score (n = 29), velocity, peak, and ETP differed from patients with low Padua score. This difference was present at 1 and 5 pM TF, in ETP ( P < .0001 and P = .003 respectively), in peak ( P < .0001 in both conditions), and in velocity ( P < .0001). According to multivariate analysis, myeloid disorders, older age, higher body mass index, myocardial infarction, C-reactive protein >5 mg/L, reduced mobility with bed rest significantly increased velocity 1 pM TF value. Conclusion: Single thrombin generation measurement could help to identify patients at risk of VTE in medical hospitalized patients.
Commissioning for menopause specialist services: A local perspective: An internet-based survey to assess the potential demand for menopause care in West Cheshire and the skills of local primary care clinicians in this field, with a view to informing future commissioning locally
Authors: Wilkinson Jane F , Short Hannah L , Wilkinson Sam , Mander Anthony 
Published: August 2015

Objective This study explores the perceived volume of women affected by peri- or post-menopausal issues that present to primary care clinicians in West Cheshire, plus the self-reported confidence of those clinicians in managing the menopause, and whether or not they feel that they and their patients should have access to a specialist menopause service. Study design Completion of an electronic survey. Population General practitioners and practice nurses working in West Cheshire. Main outcome measure To provide evidence for future local commissioning of menopause services. Results Ninety-one clinicians working within West Cheshire were sent an email request to complete the survey with 53 responses received (58%). The majority were general practitioners and were within the 35–54 year age range. The majority perceived that, each week in their clinical practice, they see between one and eight women who are affected by peri- or post-menopausal symptoms. Regarding their self-reported skills and knowledge in managing the menopause, almost half felt they had ‘good’ knowledge but ‘recognised (they) had learning needs’. Seven of the 53 (13%) felt their skills were ‘not good’. Two-thirds of those clinicians who completed the survey felt that they and their patients should have access to a specialist menopause service locally. Conclusions In the area covered by West Cheshire clinical commissioning group, there is no currently commissioned menopause service. This study has demonstrated that a substantial number of women present each week to clinicians working in this area who are felt to have peri- or post-menopausal symptoms. The clinicians have self-reported learning needs. Qualitative data from the survey would suggest training can be difficult to access. There is a clear need, both ethically and medically, for the commissioning of a West Cheshire specialist menopause service, with the proposed model being an integrated and holistic care model. Menopause care, and post-reproductive healthcare generally, provides an opportunity for collaboration and partnership working within an outcomes-based commissioning model. This study could be reviewed and replicated in other areas for comparison.
Low forced expiratory volume is associated with earlier death in sickle cell anemia
Authors: Kassim Adetola A. , Payne Amanda B. , Rodeghier Mark , Macklin Eric A. , Strunk Robert C. , DeBaun Michael R. 
Published: August 2015

Key PointsAmong adults with SCA, decreased FEV1 percent predicted was associated with earlier death. Obstructive and restrictive pulmonary function patterns do not predict earlier death in adults with SCA.
SUMOylation-disrupting WAS mutation converts WASp from a transcriptional activator to a repressor of NF-κB response genes in T cells
Authors: Sarkar Koustav , Sadhukhan Sanjoy , Han Seong-Su , Vyas Yatin M. 
Published: August 2015

Key PointsSUMOylatable-WASp trans-activates and non-SUMOylatable-WASp trans-represses NF-κB response genes mediating adaptive immunity. HDAC inhibitors reverse the immunodeficient and proinflammatory phenotype caused by SUMOylation-deficient WASp in TH1 cells.
NFI-A disrupts myeloid cell differentiation and maturation in septic mice
Authors: McClure Clara , Ali Ekram , Youssef Dima , Yao Zhi Q , McCall Charles E , El Gazzar Mohamed 
Published: August 2015

Abstract
Mounting evidence supports that sepsis-associated immunosuppression increases mortality. As potential contributors to poor sepsis outcomes, myeloid-derived suppressor cells, which are Gr1+ CD11b+ innate-immune cell progenitors unable to differentiate and possess suppressive activities, expand dramatically in septic mice by a process requiring increased microRNA-21 and microRNA-181b expression. The inhibition of these microRNAs in vivo in septic mice restores Gr1+ CD11b+ cell differentiation and maturation and improves survival. Here, we show that during sepsis-induced generation of myeloid-derived suppressor cells, transcription factor nuclear factor 1 A type represses cyclin-dependent kinase inhibitor p21 to arrest differentiation of Gr1+ CD11b+ cells. Our findings include the following: 1) Gr1+ CD11b+ myeloid cells from late septic mice genetically lacking nuclear factor 1 A type cannot suppress CD4+ T cell proliferation and activation; 2) the reconstitution of nuclear factor 1 A type in microRNA-21 and microRNA-181b-depleted Gr1+ CD11b+ myeloid-derived suppressor cells inhibits cyclin-dependent kinase inhibitor p21 and restores the immune-suppressor phenotype; 3) ex vivo nuclear factor 1 A type knockdown in Gr1+ CD11b+ myeloid-derived suppressor cells from late septic mice restores cyclin-dependent kinase inhibitor p21 expression and promotes monocyte and dendritic cell differentiation; and 4) ectopic nuclear factor 1 A type expression in normal Gr1+ CD11b+ cells generates an immunosuppressive phenotype. We suggest that therapeutically targeting nuclear factor 1 A type during late sepsis might improve survival.
Intestinal Obstruction in Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study
Authors: Madenci Arin L. , Fisher Stacey , Diller Lisa R. , Goldsby Robert E. , Leisenring Wendy M. , Oeffinger Kevin C. , Robison Leslie L. , Sklar Charles A. , Stovall Marilyn , Weathers Rita E. , Armstrong Gregory T. , Yasui Yutaka , Weldon Christopher B. 
Published: August 2015

Purpose For adult survivors of childhood cancer, knowledge about the long-term risk of intestinal obstruction from surgery, chemotherapy, and radiotherapy is limited. Methods Intestinal obstruction requiring surgery (IOS) occurring 5 or more years after cancer diagnosis was evaluated in 12,316 5-year survivors in the Childhood Cancer Survivor Study (2,002 with and 10,314 without abdominopelvic tumors) and 4,023 sibling participants. Cumulative incidence of IOS was calculated with second malignant neoplasm, late recurrence, and death as competing risks. Using piecewise exponential models, we assessed the associations of clinical and demographic factors with rate of IOS. Results Late IOS was reported by 165 survivors (median age at IOS, 19 years; range, 5 to 50 years; median time from diagnosis to IOS, 13 years) and 14 siblings. The cumulative incidence of late IOS at 35 years was 5.8% (95% CI, 4.4% to 7.3%) among survivors with abdominopelvic tumors, 1.0% (95% CI, 0.7% to 1.4%) among those without abdominopelvic tumors, and 0.3% (95% CI, 0.1% to 0.5%) among siblings. Among survivors, abdominopelvic tumor (adjusted rate ratio [ARR], 3.6; 95% CI, 1.9 to 6.8; P < .001) and abdominal/pelvic radiotherapy within 5 years of cancer diagnosis (ARR, 2.4; 95% CI, 1.6 to 3.7; P < .001) increased the rate of late IOS, adjusting for diagnosis year; sex; race/ethnicity; age at diagnosis; age during follow-up (as natural cubic spline); cancer type; and chemotherapy, radiotherapy, and surgery within 5 years of cancer diagnosis. Developing late IOS increased subsequent mortality among survivors (ARR, 1.8; 95% CI, 1.1 to 2.9; P = .016), adjusting for the same factors. Conclusion The long-term risk of IOS and its association with subsequent mortality underscore the need to promote awareness of this complication among patients and providers.
Synthesis and Chiral Recognition Ability of a Novel Fullerene-functionalized Cellulose Derivative
Authors: Gao Bo , Xu Zeyu , Fan Luan , Xu Xiaodong , Bai Jianwei , Shen Xiande 
Published: August 2015

Abstract
The fullerene-functionalized cellulose derivative 1 was synthesized and coated onto silica gel as chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC). The chiral recognition ability of the obtained chiral packing material (CPM) was evaluated by HPLC with ten types of racemates 2–11. This CPM could be used in the eluents including chloroform and terahydrofuran (THF), which are usually unsuitable solvents for conventional coating-type CPMs. Hence the scope of application of this CPM is wider than conventional coating CPM.
Obese Nondiabetic Pregnancies and High Maternal Glycated Hemoglobin at Delivery as an Indicator of Offspring and Maternal Postpartum Risks: The Prospective PEACHES Mother-Child Cohort
Authors: Ensenauer Regina , Brandlhuber Lena , Burgmann Maximiliane , Sobotzki Christina , Zwafink Carina , Anzill Sabine , Holdt Lesca , Teupser Daniel , Hasbargen Uwe , Netz Heinrich , Roscher Adelbert A , von Kries Rüdiger 
Published: August 2015

Abstract

BACKGROUND
We investigated whether obese pregnant women negative for gestational diabetes (GDM) still experience dysglycemia, as indicated by high glycated hemoglobin (Hb A1c) at delivery, and whether this impacts offspring and long-term maternal outcomes.

METHODS
Data of 462 mother-child pairs of our prospective Programming of Enhanced Adiposity Risk in Childhood – Early Screening (PEACHES) cohort study were analyzed. Of 885 obese and normal-weight pregnancies prospectively enrolled after GDM testing according to the International Association of Diabetes and Pregnancy Study Groups criteria, 462 GDM-negative mothers and their offspring were investigated. We assessed associations of maternal Hb A1c at delivery with large-for-gestational-age (LGA) birth weights, cord-blood C-peptide, and biomarkers of glucose metabolism and inflammation in obese mothers followed for 2.9 years (median) postpartum (n = 42).

RESULTS
Cumulative distribution analysis in GDM-negative normal-weight women (n = 155) revealed that 12% had Hb A1c ≥5.7% at delivery (high Hb A1c). Among obese GDM-negative women (n = 307), 31.9% (95% CI, 26.7%–37.4%) equaled or exceeded this cutoff. In obese GDM-negative women with Hb A1c ≥5.7% (n = 98) vs &lt;5.7% (n = 209) at delivery, newborns were more likely to be born LGA [adjusted odds ratio 3.56 (95% CI, 1.64–8.02)], and mean cordblood serum C-peptide was increased by 0.09 ng/mL (95% CI, 0.01–0.17 ng/mL). In the mothers at follow-up, mean postpartum Hb A1c, fasting glucose, high-sensitivity C-reactive protein, and fibrinogen concentrations were higher by 0.3% (95% CI, 0.1%–0.5%), 6.0 mg/dL (95% CI, 2.4–9.5 mg/dL), 6.8 mg/L (95% CI, 1.4–12.3 mg/L), and 74.9 mg/dL (95% CI, 13.6–136.2 mg/dL), respectively.

CONCLUSIONS
Increased Hb A1c in obese GDM-negative women at delivery indicates gestational dysglycemia, potentially conferring offspring and long-term maternal health risks. These findings should raise awareness as to careful monitoring of obese pregnancies. Measurement of Hb A1c at delivery could help select women who may need closer postpartum health checks.
La lectura intertextual en la universidad. Apuntes didácticos sobre la relación literatura-cómic
Authors: Valencia Leguizamón Mariana , Rodríguez León Daniel Mauricio , Caro Lopera Miguel Ángel 
Published: August 2015

Este artículo describe los resultados de una investigación en Didáctica de la Literatura, desarrollada con estudiantes universitarios, entre 2011 y 2012, para estimular la lectura intertextual de tres obras literarias. La investigación se basa, principalmente, en el modelo teórico y metodológico de Antonio Mendoza Fillola y el grupo FRAC (2008),<em> </em>y apela a un ejercicio hermenéutico que intenta reconocer el lenguaje del <em>cómic</em> presente en las tres novelas. De la aplicación y evaluación de las estrategias fundamentales de la intervención, se concluye, entre otros aspectos, la incidencia de la nominalización en la apropiación que el lector hace de la obra; el valor del intertexto lector en la identificación lector-personaje; la relación afectiva de los estudiantes universitarios con el mundo de los superhéroes; el impacto de la lectura intertextual en la apreciación estética del hecho literario; y el fortalecimiento de la competencia literaria, gracias el paso de la literatura al <em>cómic</em>
Encuentros y desencuentros: familia y escuela. Barreras y Desafíos para la formación
Authors: Rivillas Díaz Jhoanna 
Published: August 2015

<p>El presente artículo parte de la reflexión y puesta en escena de un proyecto de aula emprendido por tres docentes de Básica Primaria. Reflexión sobre el papel de la escuela y la familia en la época actual y los vínculos que se establecen entre ambas instituciones. Dicha reflexión se enmarca desde la observación cotidiana de los docentes con respecto al desempeño de los estudiantes y el acompañamiento realizado por los padres y/o acudientes en la formación de los niños y niñas; y bien, algunas entrevistas cuyo propósito era extraer información de tipo cualitativo sobre las actividades que realizan los niños en sus hogares y la composición familiar. Trascendiendo a la perspectiva teórica de las dos instituciones <strong>sociales</strong>: familia – escuela. Como alternativa pedagógica se plantea la experiencia vivida al interior de las aulas de clase con el proyecto de aula “aprendiendo en familia”, describiendo y narrando en qué consiste dicho proyecto, su propósito; igualmente se socializan experiencias propias de los padres de familia y docentes. </p>
La lectoescritura en nuestra actualidad: revisión crítica
Authors: Parra Pinto Fabiola 
Published: August 2015

<p>La tecnología y los avances culturales inciden en el crecimiento y experiencias de los niños afectando notablemente su aprendizaje lecto-escritor.</p><p>Importante, generar una lectura analítica-reflexiva permitiendo interpretar en forma correcta lo que el autor quiso plasmar en un texto. Así, la lectura y la escritura son herramientas básicas en el aprendizaje y la formación integral de los estudiantes, vías principales de acceso al conocimiento y a la cultura. </p><p>De esta forma, la formación de tipo mediático digital debe ser manejada por quienes hacen parte de la comunidad, pues crecer en un mundo mediático afecta notablemente tanto la capacidad lectora como escritural de quienes en este medio se desenvuelven, observándose un rendimiento académico positivo, generando manejo adecuado de los diferentes medios de comunicación de tipo digital y mediático que van surgiendo con el transcurrir del tiempo. Necesaria la reflexión y análisis frente a la incorporación de las TIC no solo en las aulas sino en la cotidianidad de cada persona.</p>
Simulación interactiva para la apropiación de la ciencia y la tecnología
Authors: Flórez Llanos Cindy Alejandra , Cristancho Sastoque Nelson Javier , Barón Velandia Julio 
Published: August 2015

<p class="Text">En este documento se presenta el avance del proyecto de investigación para la conformación de un entorno de simulación interactiva, como herramienta de apoyo a la enseñanza, mediante la aplicación de los avances de la informática, permitiendo a los niños la interacción con fenómenos que se estudian de forma didáctica, divertida y segura, aprovechando la familiaridad que ellos tienen con los dispositivos tecnológicos (tabletas, smartphones, etc.), presentado con herramientas multimedia como las utilizadas en los video juegos que capturan fácilmente su atención para presentar fenómenos del mundo de la física, mediante simulaciones interactivas de carácter lúdico que en cortos periodos de tiempo le permitan reforzar los conceptos adquiridos, a través de escenarios diseñados como apoyo a las actividades y sesiones realizadas en el aula. </p>
Geografía y sostenibilidad fuerte: relaciones conceptuales e indicadores aplicados a Ibagué, Colombia
Authors: Martínez Rivillas Alexander 
Published: August 2015

<p>La geografía contribuye de forma decidida a orientar los métodos evaluativos de la sostenibilidad fuerte, para lo cual se deben establecer enfoques espaciales de estudio de los problemas socio-ambientales. A continuación, se exponen los resultados de un estudio de caso que pretende aportar una mirada integrada y multicausal de dichos problemas, pero instalados en una noción de paisaje mediada por fuertes elementos bio-económicos y socioculturales, en el marco de las reflexiones del geógrafo George Bertrand. Finalmente, se explicitan las limitaciones y fortalezas que ofrece un método de evaluación de la sostenibilidad fuerte, en las zonas urbana y rural de Ibagué, recurriendo a la definición previa de umbrales de sostenibilidad. </p>
Kinetics of Batch Fermentation in the Cultivation of a Probiotic Strain Lactobacillus Delbrueckii Ssp. Bulgaricus B1
Authors: Goranov Bogdan , Shopska Vesela , Denkova Rositsa , Kostov Georgi 
Published: August 2015

Abstract
A comparative study of kinetic models to describe the dynamics of the fermentation process of culturing of a probiotic strain Lactobacillus delbrueckii ssp. bulgaricus B1 was performed. The models of Monod, Aiba, Tiessier, Hinshelwood and the equation of the logistic curve combined with the model of Ludeking-Piret were used. It has been found that the different models described the observed fermentation dynamics differently. The conducted comparative study demonstrated that the models of Monod and the equation of the logistic curve combined with the model of Ludeking-Piret were suitable for the description of the fermentation dynamics. The mathematical models showed no significant product and/or substrate inhibition. The culture developed with a low specific growth rate, but nevertheless it accumulated 1012-1013 viable cells. The substrate was absorbed primarily from cells in the stationary growth phase rather than cells in the exponential growth phase
Structural asymmetry of foot arch formation in early school-age children
Authors: Stodółka Jacek , Stodółka Weronika , Maćkała Krzysztof 
Published: August 2015

Summary
Study aim: the purpose of the study was to compare foot shapes in early school-age boys and girls.

Material and methods: the study included 90 boys and 98 girls aged seven to nine years old. The shape of the foot arch was examined using a podoscope. The longitudinal arch was assessed according to the Clarke angle value on the basis of Kasperczyk’s classification. The transverse arch was assessed according to the Wejsflog index. An analysis of variance, a post-hoc LSD test and a chi-square test were performed.

Results: normal transverse arches in both feet appeared in 84% of the examined children. An analysis of the average value of the Wejsflog index showed that it is similar and within limits in all of the test groups indiscriminately when it comes to gender and age. Normally, longitudinal arches in both feet occurr in 44% of children. The average value of Clarke’s index in a test group of school-age girls was within normal range while a functionally flattened foot appeared in the case of seven and eight-year-old boys.

Conclusions: the outcomes of the present study conducted on a randomly chosen group of developing boys and girls show that changes in foot structure are mostly symmetrical in nature (almost 90%), meaning that if the left foot is normal, the right one is normal, too. Gender had no effect on the foot build or arch type in either foot. The right and left feet showed symmetrical structure in the majority of the children.
N-cadherin in cancer dormancy
Authors: Sinha Garima , Rameshwar Pranela 
Published: August 2015

AbstractN-cadherin is an adhesion protein, which is important for intercellular interaction. It is involved in cell migration and motility during embryonic development, neuronal synapsis and cancer metastasis. There are several signaling cascades affected by N-cadherin including TGF-β, Rho family. N-cadherin is associated at the cytoplasmic domain with catenins (α, β, γ and p120) to facilitate metastasis. An increase in N-cadherin with down regulation of E-cadherin occurs during epithelial mesenchymal transition. Overexpression of N-cadherin is associated with cell cycle arrest, which correlates with a similar property of cancer stem cells (CSC). Connexin expression, which is important in CSC dormancy, is regulated by N-cadherin. This review discusses the potential of N-cadherin to be involved in maintaining CSCs, and to investigate pathways in N-cadherin expression. A better understanding of the role of N-Cadherin in CSC biology may identify new targets for the treatment of cancer.
Vector bundles of finite rank on complete
intersections of finite codimension in
ind-Grassmannians
Authors: Ermakova Svetlana 
Published: August 2015

Abstract
In this article we establish an analogue of the Barth-Van de Ven-Tyurin-Sato theorem.We prove that
a finite rank vector bundle on a complete intersection of finite codimension in a linear ind-Grassmannian is
isomorphic to a direct sum of line bundles.