bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of community pharmacy‐measured blood pressure and ambulatory blood pressure monitoring: A pilot study
Authors: Tran Christine , Alhomoud Ibrahim S. , Taylor Kristi , Kaefer Tana , Sabo Roy , Dixon Dave L. 
Published: June 2024

AbstractIntroductionBlood pressure (BP) measured by 24‐h ambulatory blood pressure monitoring (ABPM) is a better predictor of hypertension (HTN)‐related end‐organ damage than office BP; however, it is not always available nor tolerated by patients. Community pharmacy‐measured blood pressure (CPBP) could serve as a potential alternative, although it is unknown whether CPBP is equivalent to BP measured using ABPM.ObjectivesThe primary objective of this pilot study was to explore the equivalency of CPBP compared with awake ABPM.MethodsThis was a pilot, single‐arm, equivalency study of adults ≥21 years with HTN, taking ≥1 antihypertensive with no changes in the prior 2 weeks. Exclusion criteria included night shift workers, sleep apnoea, arrhythmia, on dialysis, pregnancy or an arm circumference > 50 cm. Three unattended seated BP measurements were obtained in both arms at a community pharmacy and followed by 24‐h ABPM. At the return visit, seated BP measurements were repeated; the mean across both visits served as the CPBP. The primary outcome was the equivalency of systolic BP measured at the community pharmacy to awake BP measured using ABPM. The continuous outcome (BP) was modelled against a binary fixed effect for the measurement device (CPBP vs. ABPM) and a subject‐level random effect to account for the multiple BP readings arising from the same individuals.ResultsThe 25 participants had a mean (standard deviation [SD]) age of 65 (15) years, 80% were female, and 36% identified as Black or Latino. The mean (SD) systolic BP was 128.0 (20.2) and 129.1 (15.8) mmHg for CPBP and awake ABPM, respectively (p = 0.8409). No significant differences were found between the mean diastolic BP or heart rate for CPBP vs. 24‐h ABPM or CPBP vs. daytime ABPM.ConclusionThe difference between CPBP and ABPM was not statistically significant; however, we cannot claim equivalence between the two approaches.
Mediation analyses of longitudinal data investigating temporal associations between inflated sense of responsibility, obsessive–compulsive symptoms, and anger suppression
Authors: Müller Celina L. , Jelinek Lena , Schmidt Alexander F. , Mannsfeld Anna K. , Miegel Franziska , Cludius Barbara 
Published: June 2024

AbstractObjectiveCognitive theories emphasize the central role of anger and anger suppression in obsessive–compulsive disorder (OCD). According to these theories, anger suppression is seen as a consequence of OCD, whereas cognitive beliefs, such as an inflated sense of responsibility, are seen as antecedent factors. To extend the findings from cross‐sectional studies, the current study investigated the temporal associations between OCD symptoms, an inflated sense of responsibility, and anger suppression. Consistent with cognitive considerations, we hypothesized that OCD symptoms mediate the association between feelings of responsibility and anger suppression. These associations were also explored in patients presenting particularly high checking‐related symptoms. Further, the stability of effects beyond controlling for depressive symptoms and medication intake was explored.MethodsA total of N = 48 patients with OCD (50% female, M = 32.46 [SD = 10.63] years of age) completed measures on obsessive beliefs, OCD symptoms, and anger suppression at three assessment points: before and after a metacognitive intervention as well as at a follow‐up 6 months later. Mediation models investigating symptom associations at these three timepoints were conducted. Exploratory analyses investigating these associations in individuals presenting high checking‐related symptoms (n = 20) and testing the stability of effects beyond controlling for depressive symptoms and medication intake were conducted.ResultsThe sense of responsibility did not significantly predict the level of anger suppression. A temporal association between OCD symptoms (as assessed with the self‐report measure) and anger suppression could be evidenced, which was stable beyond controlling for depressive symptoms and medication intake. Against the expectations based on cognitive theories, the sense of responsibility did not predict OCD symptoms. No mediating effect of OCD symptoms was found.ConclusionIn line with cognitive viewpoints, the present study shows that higher OCD symptoms predict higher levels of anger suppression in a longitudinal design, thereby contributing to the suppression of anger. This effect seems to be independent from depressive symptoms and medication intake. The effect of sense of responsibility on OCD symptoms was less clear and could only be found in the subgroup of patients with OCD and checking‐related symptoms, who generally presented higher levels of responsibility. Overall, this is the first study demonstrating temporal associations between OCD symptoms and anger suppression. Acknowledging that anger and anger suppression may be a consequence of OCD symptoms and may also affect aspects of psychotherapy, which can ultimately inform future adjustments to psychotherapeutic treatment.
Loss of NLRP6 increases the severity of kidney fibrosis
Authors: Valiño‐Rivas Lara , Pintor‐Chocano Aranzazu , Carriazo Sol M. , Sanz Ana B. , Ortiz Alberto , Sanchez‐Niño Maria D. 
Published: June 2024

AbstractWhile NLRP3 contributes to kidney fibrosis, the function of most NOD‐like receptors (NLRs) in chronic kidney disease (CKD) remains unexplored. To identify further NLR members involved in the pathogenesis of CKD, we searched for NLR genes expressed by normal kidneys and differentially expressed in human CKD transcriptomics databases. For NLRP6, lower kidney expression correlated with decreasing glomerular filtration rate. The role and molecular mechanisms of Nlrp6 in kidney fibrosis were explored in wild‐type and Nlrp6‐deficient mice and cell cultures. Data mining of single‐cell transcriptomics databases identified proximal tubular cells as the main site of Nlrp6 expression in normal human kidneys and tubular cell Nlrp6 was lost in CKD. We confirmed kidney Nlrp6 downregulation following murine unilateral ureteral obstruction. Nlrp6‐deficient mice had higher kidney p38 MAPK activation and more severe kidney inflammation and fibrosis. Similar results were obtained in adenine‐induced kidney fibrosis. Mechanistically, profibrotic cytokines transforming growth factor beta 1 (TGF‐β1) and TWEAK decreased Nlrp6 expression in cultured tubular cells, and Nlrp6 downregulation resulted in increased TGF‐β1 and CTGF expression through p38 MAPK activation, as well as in downregulation of the antifibrotic factor Klotho, suggesting that loss of Nlrp6 promotes maladaptive tubular cell responses. The pattern of gene expression following Nlrp6 targeting in cultured proximal tubular cells was consistent with maladaptive transitions for proximal tubular cells described in single‐cell transcriptomics datasets. In conclusion, endogenous constitutive Nlrp6 dampens sterile kidney inflammation and fibrosis. Loss of Nlrp6 expression by tubular cells may contribute to CKD progression.
A highly effective method for the environmentally friendly production of novel chromene derivatives using electron deficient compounds
Authors: Shafaei Faezeh , Hargalani Fariba Zamani , Ghazvini Maryam 
Published: June 2024

AbstractNew, high‐yield derivatives of oxepino[3,2‐c]chromene were synthesized through a multicomponent reaction. This reaction involved 2‐hydroxyacetophenone, dimethyl carbonate, activated acetylenic compounds, and alkyl bromide. The reaction took place at room temperature in an aqueous environment, resulting in the formation of these innovative compounds. Oxathiepines were synthesized using multicomponent reactions of 2‐hydroxyacetophenone, dimethyl carbonate, isothiocyanate, and alkyl bromide in water at room temperature. This technology offers several benefits, including quick response times, high product yields, and easy product separation using straightforward techniques.
An Insightful Overview of Microbial Biosurfactant: A Promising Next‐Generation Biomolecule for Sustainable Future
Authors: Thundiparambil Venu Athira , Vijayan Jasna , Ammanamveetil Mohamed Hatha Abdulla , Kottekkattu Padinchati Krishnan 
Published: June 2024

ABSTRACTMicrobial biosurfactant is an emerging vital biomolecule of the 21st century. They are amphiphilic compounds produced by microorganisms and possess unique properties to reduce surface tension activity. The use of microbial surfactants spans most of the industrial fields due to their biodegradability, less toxicity, being environmentally safe, and being synthesized from renewable sources. These would be highly efficient eco‐friendly alternatives to petroleum‐derived surfactants that would open up new approaches to research on the production of biosurfactants. In the upcoming era, biobased surfactants will become a dominating multifunctional compound in the world market. Research on biosurfactants ranges from the search for novel microorganisms that can produce new molecules, structural and physiochemical characterization of biosurfactants, and fermentation process for enhanced large‐scale productivity and green applications. The main goal of this review is to provide an overview of the recent state of knowledge and trends about microbially derived surfactants, various aspects of biosurfactant production, definition, properties, characteristics, diverse advances, and applications. This would lead a long way in the production of biosurfactants as globally successful biomolecules of the current century.
Controlling the antibacterial activity of surfactants by hydrotrope addition
Authors: Kurose Mina , Sato Tomohiro , Yano Shigekazu , Nonomura Yoshimune 
Published: June 2024

AbstractHydrotropes are amphiphiles that improve the water solubility of hydrophobic substances. In this study, we systematically evaluated the effects of eight hydrotropes on the antibacterial activity of fatty acids solubilized in a micellar system. The antibacterial activity was evaluated using minimum inhibitory concentration (MIC) as an indicator, and CMC was calculated for interfacial properties based on the measurement of the surface tension and the solubilization behavior of the oil‐soluble dye. The solubilization of lauric acid (12:0 FA) in the micelles of nonionic surfactants increased and decreased the antibacterial activities of the surfactants against Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis, respectively. The addition of the hydrotropes decreased the antibacterial activity of the surfactants against both Staphylococci. However, on introducing small amounts of 12:0 FA, the surfactants exhibited selective antibacterial activity against S. aureus. These antibacterial phenomena were observed at concentrations above the critical micelle concentration of the surfactants. These findings suggest that the addition of hydrotropes affects the interfacial properties and antibacterial activity of micellar systems containing antibacterial ingredients.
From leaf to harvest: achieving sustainable agriculture through advanced disease prediction with DBN‐EKELM
Authors: Rajasekar Deepa , Moorthy Vaishnavi , Rajadurai Priscilla , Ravikumar Sethuraman 
Published: June 2024

AbstractBackgroundIn the agricultural sector, the early identification of plant diseases presents a pressing challenge. Throughout the growing season, plants remain vulnerable to an array of diseases. Failure to detect these diseases at their early stages can significantly compromise the overall yield, thereby reducing profitability for farmers. To address this issue, several researchers have introduced standard methods that leverage machine learning and deep learning techniques. However, many of these methods offer limited classification accuracy and often necessitate extensive training parameter adjustments.MethodThe objective of this study is to develop a new deep learning‐based technique for detecting and classifying plant diseases at earlier stages. Thus, this paper introduces a novel technique known as the deep belief network‐based enhanced kernel extreme learning machine (DBN‐EKELM) that identifies a disease automatically and performs effective classification. The initial phase involves data preprocessing to enhance quality of plant leaf images, facilitating the extraction of critical information. With the goal of achieving superior classification accuracy, this paper proposes the use of the DBN‐EKELM technique for optimal plant leaf disease detection. Given that KELM parameters are highly sensitive to minor variations, proper parameter tuning is essential and introduces a novel binary gaining sharing knowledge‐based optimization algorithm (NBGSK).ResultThe efficacy of the proposed DBN‐EKELM method is evaluated by comparing its performance with other conventional methods, considering various measures like accuracy, precision, specificity, sensitivity and F‐measure.ConclusionExperimental analyses demonstrate that the DBN‐EKELM technique achieves an impressive rate of approximately 98.2%, 97%, 98.1%, 97.4% as well as 97.8%, surpassing other standard methods. © 2024 Society of Chemical Industry.
Patellofemoral joint cartilage lesions frequently develop shortly after anterior cruciate ligament reconstruction using hamstring tendon autograft: A systematic review
Authors: Han Joo Hyung , Jung Min , Chung Kwangho , Moon Hyun‐Soo , Jung Se‐Han , Moon Seungeon , Kim Sung‐Hwan 
Published: June 2024

AbstractPurposeThis study aimed to investigate the development of patellofemoral joint (PFJ) cartilage lesions following anterior cruciate ligament reconstruction (ACLR) using hamstring tendon (HT) autograft through a systematic review.MethodsA comprehensive search was conducted in PubMed, Embase, Cochrane Library and Google Scholar databases to find articles published from database inception until 15 November 2023. The search terms were [(‘Anterior Cruciate Ligament’ [mesh] OR ‘anterior cruciate ligament’ OR ‘ACL’) AND ‘reconstruction’ AND ‘cartilage’ AND (‘second look arthroscopy’ OR ‘second‐look arthroscopy’ OR ‘MRI’ OR ‘magnetic resonance imaging’)]. Inclusion criteria were studies that reported on the occurrence of PFJ cartilage lesions following ACLR using HT autograft, as determined by second‐look arthroscopy or follow‐up magnetic resonance imaging (MRI).ResultsFifteen studies (1084 patients) met the inclusion criteria, with follow‐up periods ranging from 1 to 5 years. In the results of second‐look arthroscopy, cartilage grade deterioration was observed, ranging from MDs of 0.1 to 2.0 in the patella and from 0 to 1.0 in the trochlea. Follow‐up MRI results reported the incidence of PFJ cartilage degeneration with rates ranging from 20% to 44%. Patient‐reported outcome measures often showed no significant association with PFJ cartilage lesions. The studies included in this review reported various risk factors for cartilage lesion development.ConclusionCartilage lesions in the PFJ, detected using second‐look arthroscopy or follow‐up MRI, frequently develop shortly after ACLR using HT autograft. At this stage, patients might not show specific symptoms; however, those with risk factors require careful observation and evaluation by clinicians during follow‐up.Level of EvidenceLevel IV.
Color‐Tunable White Circularly Polarized Electroluminescence Triggered Using Chiral Co‐Assembly‐Sensitized Strategy
Authors: Zhang Yu , Tian Guokai , Li Dong , Jiang Zhenhao , Quan Yiwu , Cheng Yixiang 
Published: June 2024

AbstractWhite circularly polarized organic light‐emitting diodes (CP‐WOLEDs) are central to prospective 3D displays and lighting sources. However, owing to the unwanted charge trapping effect and inefficient chirality transfer, the development of CP‐WOLEDs with a high color rendering index (CRI) and large dissymmetry factor (gEL) is challenging. Herein, a pioneering strategy of chiral co‐assembly‐sensitized circularly polarized luminescence (CCS‐CPL) is proposed for improving the performance of white circularly polarized electroluminescence (CP‐EL). Chiral co‐assembled sensitizers ((S‐/R‐Cz)0.2‐(I‐P)0.8) are smartly developed using π–π stacking interactions between the chiral binaphthyl derivatives (S‐/R‐Cz) and achiral conjugated pyrene‐based polymer (I‐P) in a molar ratio of 1:4. Using the chiral co‐assembly‐sensitized strategy on achiral aggregation‐induced emission (AIE) dyes for emitting layers (EMLs) of OLEDs, full‐color achiral AIE‐active dyes can be sensitized by chiral co‐assembly (S‐/R‐Cz)0.2‐(I‐P)0.8. The color‐tunable white CP‐EL performance can be achieved at the CIE coordinates of (0.33, 0.33) with an ultrahigh CRI of 93 and a large gEL value up to 0.071. This study thus provides a valuable guidance for CCS‐type CP‐WOLEDs.
Photonic Neural Network Fabricated on Thin Film Lithium Niobate for High‐Fidelity and Power‐Efficient Matrix Computation
Authors: Zheng Yong , Wu Rongbo , Ren Yuan , Bao Rui , Liu Jian , Ma Yu , Wang Min , Cheng Ya 
Published: June 2024

AbstractPhotonic neural networks (PNNs) have emerged as a promising platform to address the energy consumption issue that comes with the advancement of artificial intelligence technology, and thin film lithium niobate (TFLN) offers an attractive solution as a material platform mainly for its combined characteristics of low optical loss and large electro‐optic (EO) coefficients. Here, the first implementation of an EO tunable Mach‐Zehnder interferometer (MZI) mesh‐based TFLN PNN is presented. The device features ultra‐high fidelity, high computation speed, and exceptional power efficiency. The performance of the device is benchmarked with several deep learning missions including in situ training of Circle and Moons nonlinear datasets classification, Iris flower species recognition, and handwriting digits recognition. The work paves the way for sustainable up‐scaling of high‐speed, energy‐efficient PNNs.
Corrosion studies of SS 316H and Alloy 617 in thermally purified molten NaF‐KF‐UF4‐UF3 salts
Authors: Yang Qiufeng , Leong Amanda , Zhang Jinsuo 
Published: June 2024

AbstractThe study investigates salt chemistry and corrosion behavior of SS 316H and Alloy 617 in thermally purified molten NaF‐KF‐UF4‐UF3 salts (UF4/UF3 initial ratio 12–14) at 800°C for 120, 72, and 32 h. UF4/UF3 ratio increases after corrosion tests. Cr species concentration in salts keeps increasing. Fe, Co, Ni, and Mo species increase first, then decrease. Cr/Mn oxides are formed along grain boundaries in SS 316H. Cr near the surface of Alloy 617 is completely depleted. A thin layer composed of Fe, Co, Ni, and Mo is observed on the Alloy 617 surface in 72‐h and 32‐h tests.
Extrapolation results on variable exponent grand Lebesgue space with Bp(·)$B_{p(\cdot)}$ weights
Authors: Singh Monika 
Published: June 2024

AbstractIn this paper, we study Rubio de Francia extrapolation theorems in the framework of the variable grand Lebesgue spaces with weights. As an application of the extrapolation theorems, we prove the boundedness of the Hardy averaging operator and the fractional Riemann Liouville transform for nonnegative and nonincreasing measurable functions. Some structural properties of the weighted grand Lebesgue spaces with variable exponent are also investigated.
UV Light‐Driven Nitric Oxide Release from Porous Nitrogen Heterocyclic Polymers
Authors: Gregg Sharon T. , Nze René‐Ponce , Yuan Qingchun , He Su , Xie Tianchao , Xiao Bo 
Published: June 2024

AbstractIn this study, porous polymers with nitrogen heterocyclic core structures are synthesized through the condensation of enaminonitrile and terephthalaldehyde monomers. These polymers are used as a platform to store bioactive nitric oxide (NO) and control its release. NO loading is achieved by nitrosating the polymers with acidified nitrite, a process that also imparts photoresponsivity to the polymers. Polymer composition and porosity affect NO storage and release. It is observed that under UV light at 365 nm in a PBS solution, the polymers (NO@DHP‐POP) can release NO in a manner fully controlled by UV lighting. Under experimental conditions, these porous polymers release NO at a rate of ≈10.0–50.0 µmol g−1 over 60 min. These findings demonstrate the potential of these polymers for integrating NO delivery into phototherapy applications.
Mass spectrometry imaging of N‐linked glycans: Fundamentals and recent advances
Authors: Palomino Tana V. , Muddiman David C. 
Published: June 2024

AbstractWith implications in several medical conditions, N‐linked glycosylation is one of the most important posttranslation modifications present in all living organisms. Due to their nontemplate synthesis, glycan structures are extraordinarily complex and require multiple analytical techniques for complete structural elucidation. Mass spectrometry is the most common way to investigate N‐linked glycans; however, with techniques such as liquid‐chromatography mass spectrometry, there is complete loss of spatial information. Mass spectrometry imaging is a transformative analytical technique that can visualize the spatial distribution of ions within a biological sample and has been shown to be a powerful tool to investigate N‐linked glycosylation. This review covers the fundamentals of mass spectrometry imaging and N‐linked glycosylation and highlights important findings of recent key studies aimed at expanding and improving the glycomics imaging field.
5,7,4′‐Trimethoxyflavone triggers cancer cell PD‐L1 ubiquitin–proteasome degradation and facilitates antitumor immunity by targeting HRD1
Authors: Xia Jianhua , Xu Mengting , Hu Hongmei , Zhang Qing , Yu Dianping , Cai Minchen , Geng Xiangxin , Zhang Hongwei , Zhang Yanyan , Guo Mengmeng , Lu Dong , Xu Hanchi , Li Linyang , Zhang Xing , Wang Qun , Liu Sanhong , Zhang Weidong 
Published: June 2024

AbstractTargeting the programmed cell death 1/programmed cell death ligand 1 (PD‐1/PD‐L1) pathway has been identified as a successful approach for tumor immunotherapy. Here, we identified that the small molecule 5,7,4′‐trimethoxyflavone (TF) from Kaempferia parviflora Wall reduces PD‐L1 expression in colorectal cancer cells and enhances the killing of tumor cells by T cells. Mechanistically, TF targets and stabilizes the ubiquitin ligase HMG‐CoA reductase degradation protein 1 (HRD1), thereby increasing the ubiquitination of PD‐L1 and promoting its degradation through the proteasome pathway. In mouse MC38 xenograft tumors, TF can activate tumor‐infiltrating T‐cell immunity and reduce the immunosuppressive infiltration of myeloid‐derived suppressor cells and regulatory T cells, thus exerting antitumor effects. Moreover, TF synergistically exerts antitumor immunity with CTLA‐4 antibody. This study provides new insights into the antitumor mechanism of TF and suggests that it may be a promising small molecule immune checkpoint modulator for cancer therapy.