bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of intravenous immunoglobulin in an Asian paediatric population over a 10‐year period
Authors: Wu Jethro , Lee Alison Joanne , Goh Anne Eng‐Neo , Chia Moira , Ho Christopher , Bugarin Jackelyn Laycano , Shek Lynette Pei‐Chi , Chan Yiong‐Huak , Lee Bee‐Wah 
Published: June 2013

AimsThere is a paucity of data on the pattern of intravenous immunoglobulin (IVIG) usage in the paediatric population. This study aimed to assess the prevalence, trends, indications and burden of cost of IVIG usage in the Singaporean paediatric population.MethodsPharmacy data of all IVIG prescriptions between 2000 and 2009 in the two major paediatric public hospitals in Singapore were retrospectively reviewed. Each prescription was cross‐referenced with the patient's hospital records to confirm the administration of IVIG and indication of use.ResultsOver the 10‐year period, a total 78 155 g of IVIG valued at an estimated $5.2 million was prescribed. There was an increasing trend of 445.6 g/year (P = 0.02) over this period. Analysis of patients showed that the most common indication for IVIG use was Kawasaki disease, both in terms of the proportion of patients (60%) and amount of IVIG used (34%). Kawasaki disease was also the only indication where there were significant increasing trends in both patient numbers (7.4 patients/year) and amount of IVIG used (247.5 g/year). The indications with the highest amount of IVIG used per patient were for conditions related to primary immunodeficiency diseases and stem cell transplantation, where repeat transfusions were required. More than 75% of indications were Food and Drug Administration approved.ConclusionAlbeit substantial and increasing, the use of IVIG in Singaporean children is mostly evidence based.
Genetic and clinical contributions to cerebral palsy: A multi‐variable analysis
Authors: O'Callaghan Michael E , MacLennan Alastair H , Gibson Catherine S , McMichael Gai L , Haan Eric A , Broadbent Jessica L , Baghurst Peter A , Goldwater Paul N , Dekker Gustaaf A ,   Australian Collaborative Cerebral Palsy Research Group
Published: June 2013

AimThis study aims to examine single nucleotide polymorphism (SNP) associations with cerebral palsy in a multi‐variable analysis adjusting for potential clinical confounders and to assess SNP–SNP and SNP–maternal infection interactions as contributors to cerebral palsy.MethodsA case control study including 587 children with cerebral palsy and 1154 control children without cerebral palsy. Thirty‐nine candidate SNPs were genotyped in both mother and child. Data linkage to perinatal notes and cerebral palsy registers was performed with a supplementary maternal pregnancy questionnaire. History of known maternal infection during pregnancy was extracted from perinatal databases.ResultsBoth maternal and fetal carriage of inducible nitric oxide synthase SNP rs1137933 were significantly negatively associated with cerebral palsy in infants born at less than 32 weeks gestation after adjustment for potential clinical confounders and correction for multiple testing (odds ratio 0.55, 95% confidence interval 0.38–0.79; odds ratio 0.57, 95% confidence interval 0.4–0.82, respectively). Analysis did not show any statistically significant SNP–SNP or SNP–maternal infection interactions after correction for multiple testing.ConclusionsMaternal and child inducible nitric oxide synthase SNPs are associated with reduced risk of cerebral palsy in infants born very preterm. There was no evidence for statistically significant SNP–SNP or SNP–maternal infection interactions as modulators of cerebral palsy risk.
Predictors of adolescents' health‐promoting behaviors guided by primary socialization theory
Authors: Rew Lynn , Arheart Kristopher L. , Thompson Sanna , Johnson Karen 
Published: June 2013

AbstractPurposeThe purpose of this study was to determine the influence of parents and peers on adolescents' health‐promoting behaviors, framed by primary socialization theory.Design and MethodLongitudinal data collected annually from 1,081 rural youth (mean age = 17 ± 0.7; 43.5% males; 44% Hispanic) and once from their parents were analyzed using generalized linear models.ResultsParental monitoring and adolescent's religious commitment significantly predicted all health‐promoting behaviors (nutrition, physical activity, safety, health practices awareness, and stress management). Other statistically significant predictors were parent's responsiveness and health‐promoting behaviors. Peer influence predicted safety and stress management.Practice ImplicationsNurses may facilitate adolescents' development of health‐promoting behaviors through family‐focused interventions.
Foraging strategies associated with alternative reproductive tactics in a large mammal
Authors: Corlatti L. , Bassano B. , Valencak T. G. , Lovari S. 
Published: June 2013

AbstractForaging behaviour plays a key role in growth, survival and reproduction. Male ungulates in temperate environments show seasonal fluctuations in uptake and use of energy, with summer accumulation of reserves later used to sustain the costs of the mating season. To date, however, very little information is available on the foraging behaviour of individuals adopting alternative reproductive tactics. We investigated the year‐round foraging strategies of nine territorial and 10 non‐territorial male Alpine chamois Rupicapra rupicapra in the Gran Paradiso National Park (Italy), and discussed them in relation to space use and forage quality. Territorial males showed marked seasonal changes in foraging behaviour, with low values of time spent foraging in spring, followed by an increase in summer, a drop in November and a subsequent increase in winter. The foraging rates of non‐territorial males, on the other hand, showed smaller variation, decreasing gradually from spring to autumn, and increasing in winter, but with no significant reduction during the November rut. Although in summer territorial males remained at lower elevations than non‐territorial males, faecal crude protein did not show any significant difference between male types. The effort to establish and defend territories (in spring and in November, respectively) may constrain foraging in territorial males, forcing them to compensate by increasing their energy intake over summer. Different levels of vertical movements in the warm months did not affect forage quality, suggesting that territorial males may be selective in the choice of palatable plants. Our results show that different reproductive tactics imply different foraging strategies over the year, which do not seem to depend on forage quality. Different foraging strategies over summer may possibly lead to different body conditions at the beginning of the mating season, which, in turn, could influence individual capability to cope with the costs of mating.
Undermining incision and healing of deep pressure ulcers: A prospective cohort study of pressure ulcers by the Japanese National Hospital Organization
Authors: Nagase Takashi , Iizaka Shinji , Kato Hirofumi , Nakagami Gojiro , Kaitani Toshiko , Machida Masafumi , Oshima Hideo , Ochiai Hiroko , Bito Seiji , Sanada Hiromi ,   ASPU Group
Published: June 2013

AbstractUndermining is one of the most challenging complications of deep pressure ulcers. Recommendations in most guidelines are based only on expert opinions. Here, we examined the relationship between surgical incision of the undermined space and pressure ulcer healing through a Japanese multicenter prospective cohort study. A total of 162 patients with undermining in 40 national hospitals in Japan were enrolled from July 2007 to June 2009. The incision group included 39 patients (24.1%) whose undermining was surgically incised during the observational period. Their 4‐week follow‐up data on pressure ulcer severity and areas of healthy granulation tissue were recorded as outcome variables using the DESIGN‐R pressure ulcer assessment tool. The 4‐week follow‐up was restarted after the incision in the incision group. The outcome variables over time were compared between the two groups using a linear mixed model with or without adjustment for demographic and other variables. The incision group showed more rapid improvement in the total and granulation DESIGN‐R scores compared with the nonincision group (p < 0.001 and p = 0.007, respectively, in the crude models). This study may provide the first considerable evidence to support that surgical incision of undermining may promote healing of deep pressure ulcers.
Complete Sequences of Two Plasmids in a
bla
NDM-1
-Positive Klebsiella oxytoca Isolate from Taiwan
Authors: Huang Tzu-Wen , Wang Jann-Tay , Lauderdale Tsai-Ling , Liao Tsai-Lien , Lai Jui-Fen , Tan Mei-Chen , Lin Ann-Chi , Chen Ying-Tsong , Tsai Shih-Feng , Chang Shan-Chwen 
Published: June 2013

ABSTRACT

Genetic determinants of a
bla
NDM-1
-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX_NDM1 and pKOX-R1, were identified for the
Klebsiella oxytoca
strain E718. Sequence annotation revealed a
bla
NDM-1
gene in pKOX_NDM1 and two extended-spectrum β-lactamase producers (
bla
CTX-M-3
and
bla
SHV-12
) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrug-resistant bacterial infections and the potential danger of emerging resistant enterobacteria.
CLINICAL AND RADIOLOGICAL RESULTS OF ARTHROSCOPIC REPAIR OF MASSIVE ROTATOR CUFF TEARS DOES IT IMPROVE THE NATURAL HISTORY
Authors: Chrysi Tsiouri , Chidanbaram Ramiah , Frankiskos Xypnitos , Mok Daniel H 
Published: June 2013

BackroundIs there a reason for repairing massive cuff tears.Methods58 consecutive patients with a massive rotator cuff tear had arthroscopic repair between November 2004 and May 2006 with the presented technique. The average age was 68.4 years ( 49–86).Mean follow up was 46.2 months (38–56). Thirty of those patients were available for review 20 months later, follow up 65(53–76) 0.33 had ultrasound and 34 had X raysResultsIn 45 patients available for scoring the mean Oxford score was 44(19–48) with 42 (93%) graded as excellent or good and only one poor result and at final review 45 (27–48).The mean postoperative Constant score at follow up was 74(32.8–97.4) rising to 76 (41–96) in 2011 and statistical analysis showed that improvement in both Oxford and Constant scores was significant(probability <0.05). There was a statistically significant improvement regarding pain, movement and activities of daily living but not strength. Ultrasound findings correlated with postoperative strength and Constant scores but not with any other factor or the Oxford score. Similar was the correlation for radiographic osteoarthritis. At final follow up, improvements in all scores remain statistically significant whether there is a retear or thinning or development of osteoarthritis or not.ConclusionThe results suggest that arthroscopic repair of massive rotator cuff tears can achieve excellent clinical results The outcome in the longer term is unknown.
PLATELET-RICH PLASMA (PRP) TO TREAT CHRONIC UPPER PATELLAR TENDINOPATHIES
Authors: Kaux J F , Croisier J L , Bruyère O , Rodriguez C , Daniel C , Godon B , Simoni P , Alvarez V , Brabant G , Lapraille S , Lonneux V , Noël D , Collette J , Goff C Le , Gothot A , Crielaard J M 
Published: June 2013

BackgroundUpper patellar tendinopathies remain often chronic and rebel to a thorough conservative treatment. Moreover, the option of a surgical treatment could be disappointing. New treatments are being developed. Injection of PRP is one of these. Platelets contain lot of growth factors which would have the potentiality to enhance the healing process of tendons. Even if in vitro and animal experiments have demonstrated this stimulation of tendon healing process,1clinical series are subject to controversy.2MethodsTwenty patients with chronic upper patellar tendinopathy were enrolled. Assessments [VAS, clinical examination with an algometer, algofunctional scores (IKDC and VISA-P), functional assessments (isokinetic and Optojump) and imagery (ultrasounds and MRI)] were made before infiltration of PRP, and 6 weeks and 3 months after. The PRP was obtained by an apheresis system (COM.TEC, Fresenius). Six millilitres of PRP were injected without local anaesthetic. One week after infiltration, patients started a 6-week standardised sub-maximal eccentric reeducation.ResultsWe observed a very significant improvement of the algofunctional status as soon as 6 weeks after the infiltration of PRP, and continued to a lesser extent up to 3 months. During functional evaluation, pain decreased as well, but without significant improvement of performances. No significant improvements in the imagery were observed. Interestingly, patients who had a VAS equal or below 1 after 3 months post-infiltration were younger (24.7 vs 32.2 y.o.). Moreover, these younger patients had a significant increase of the IKDC score (p=0.003), a significant improvement of pain during isokinetic evaluations (p<0.05), and during Optojump assessments (p=0.01). Seventy-five percent of subjects were able to return to sport, even if only half of these patients recovered the same level than before the tendinopathy.Discussion/ConclusionsThis study demonstrates that a local infiltration of PRP associated with a submaximal eccentric protocol is efficient to improve symptoms of chronic upper patellar tendinopathies, non-responsive to classical conservative treatments. However, up to now, there is no consensus on the method to prepare the PRP. Indeed, each technique could provide a very different PRP (variations in the platelet concentrations and of the amount of red and white cells).
EFFECTS OF RECOVERY TYPE ON JUDOKAS' SHORT-TERM MAXIMAL PERFORMANCES DURING A SIMULATED COMPETITION
Authors: Hamdi Chtourou , Hana Baklouti , Asma Aloui , Najla Ismaïl , Liwa Masmoudi , Karim Chamari , Anis Chaouachi , Nizar Souissi 
Published: June 2013

BackgroundScientific data regarding the effects of different forms of recovery on judokas' anaerobic performances during successive judo matches are lucking. Moreover, to our knowledge, no relevant studies have examined the effects of the combined-recovery (passive-active-passive) on these performances. Therefore, the present study aimed to examine the effect of three recovery modes (i.e., passive recovery, active recovery, and combined recovery) on judokas' anaerobic performances during a simulated competition.MethodsTwelve male black belt judokas performed three test sessions, with one recovery type at each session [active (running at 50% of maximal-aerobic-velocity, passive, and combined-recovery (4 min passive-recovery, 7min active-recovery, and 4-min passive-recovery)]. During each session, the judokas performed the squat-jump (SJ), the countermovement-jump (CMJ), the hand-grip (HG), and the isometric-lumbar-contraction (ILC) tests before and after two 5-min judo matches separated with a 15-min recovery, and after a 15-min recovery subsequent to the second judo match.ResultsPerformances during the SJ and CMJ, HG and ILC were higher in the combined-recovery condition compared to the passive-recovery one. Moreover, HG was higher after the combined-recovery than the active-recovery before the second combat. Besides, ILC was higher after the active-recovery compared to the passive-recovery before the second combat, and higher after the combined-recovery than the active-recovery 15-min after the second combat.Discussion/conclusionsJudo is a dynamic, high-intensity-intermittent-combat-sport where the anaerobic system provides the short, quick, all-out bursts of maximal power during the match, while the aerobic system contributes to the judoka's ability to sustain effort for the total duration of the combat, to recover during the brief periods of rest or reduced effort, and to an effective recovery between matches. Therefore, active recovery could not be used between judo matches since the judokas need some minutes for muscles relaxation and to concentrate prior to the upcoming combat since judo requires tactical excellence.
EFFICACY OF ACUTE HIGH-INTENSITY INTERVAL TRAINING IN LOWERING GLYCEMIA IN PATIENTS WITH TYPE 2 DIABETES: DIABETES EM MOVIMENTO® PILOT STUDY
Authors: Mendes Romeu , Sousa Nelson , Garrido Nuno , Rocha Pedro , Themudo Barata José Luís , Reis Victor Machado 
Published: June 2013

BackgroundHigh-intensity interval training (HIIT) is characterized by brief periods of high-intensity aerobic exercise interspersed with periods of rest or active recovery and has been reported to be more effective than moderate-intensity continuous training for improving several health outcomes. However, safety and efficacy of HIIT in high-risk patient populations, like type 2 diabetic patients, needs to be established. This study aims to analyze the acute effects of HIIT in postprandial blood glucose levels in patients with type 2 diabetes.MethodsThis was a randomized crossover study. Twelve individuals with type 2 diabetes (diagnosed at 5.83±3.13 years; six men and six women; age 58.67±5.35 years; glycated hemoglobin 7.08±1.18 %; body mass index 30.07±5,64 kg/m2) treated with oral hypoglycemic agents (metformin, N=5; metformin+sitagliptin, N=4; metformin+vildagliptin, N=3) underwent a single exercise session of high-intensity interval training on treadmill and a control session of seated rest with one week apart in a random order. Exercise session consisted in a 5-min warm-up followed by 5 series of 3-min brisk walking at 70% of heart rate reserve (HRR), interspersed with 3-min at 30% HRR. In the end a 5-min cool-down was carried, totaling a 40-min exercise session. Treadmill speed and grade were adjusted to induce the defined intensity. Training zones were calculated with Karvonen HRR method. Sessions were held in the morning period during standardized breakfast postprandial state. Capillary blood glucose was measured at baseline (fasting state), immediately before sessions (0 min), during sessions (10, 20 and 30 min) immediately after sessions (40 min) and during recovery (50, 60, 70, 80 and 90 min).ResultsAfter exercise start, blood glucose levels were always lower compared to control. However, two-way ANOVA (conditionxtime) with repeated measures only identified statistically significant diferences at minute 20 (155.92±51.13 vs. 110.58±47.07 mg/dl, p=0.034), 30 (148.50±55.58 vs. 95.08±44.77 mg/dl, p=0.017), 40 (137.42±48.60 vs. 91.17±38.71 mg/dl, p=0.017) and 50 (134.00±52.91 vs. 94.25±38.33 mg/dl, p=0.047). No acute adverse events occurred during exercise or recovery: no symptomatic hypoglycemia, hyperglycemia, no symptoms of myocardial ischemia or stroke and no musculoskeletal injuries.ConclusionsHIIT appears to be an effective and safe exercise strategy to acutely control blood glucose in patients with type 2 diabetes.Trial funding and registrationDiabetes em Movimento®is funded by Portuguese Foundation for Science and Technology with reference SFRH/BD/47733/2008 and is registered in Current Controlled Trials with referenceISRCTN09240628.
RADIOLOGICAL EVALUATION IN YOUNG PATIENTS WITH ATLAS FRACTURES DURING PROFESSIONAL AND AMATEUR SPORT
Authors: Syrmos Nikolaos , Mylonas A , Gavridakis G , Grigoriou K , Valadakis V , Iliadis C , Arvanitakis D 
Published: June 2013

BackgroundRadiological evaluation is very important in spinal trauma patients during sport activities, specially in cases with atlas fractures.AimAim of this study was to analyze the radiological evaluation and the role of X-ray, CT and MRI findings in 12 young patients with atlas fractures during sport activities (amateur and professional).Material and MethodsDuring a 12 year period (2000–2012) we analyzed 12 patients with atlas fractures during sport activities (amateur and professional). Ten male, two female, mean age 25, range from 16 to 30 years.ResultsAll of them 12,100% had admission X-rays and CT-scan that confirmed the presence of an atlas fracture. Ten patients,had also MRI-scan (group 1), two patients, only X-rays and CT-scan (group 2). We analyzed also the type of sport activity, amateur (group A, 6 patients 50%), professional (group B, 6 patients, 50 %), then the timing of injury, recent trauma (group I, 11 patients) and chronic trauma, more than seven days after the initial injury (group II, 1 patient). Two Jefferson burst fractures, four bilateral posterior arch fracture, one comminuted lateral mass fractures, one linear lateral mass fractures, one unilateral ring fracture, one asymmetric anterior and posterior arch fractures, two bilateral anterior arch fracture. Six patients were treated with Halo-Vest and Six Patients with Philadelphia Collar The average follow up was 18 months.ConclusionsFurther studies were warranted but the combination of CT and MRI is is very useful for the evaluation and for the therapeutic approach of spinal trauma patients, specially in cases with atlas fractures. The long term stability seems to have good results.
IMPORTANCE OF GENETIC VARIANTS AND ETHNICITY IN NON-CONTACT MUSCULOSKELETAL SOFT TISSUE INJURIES
Authors: Ricard Pruna , Rosa Artells , Jordi Ribas , Bruno Montoro , Mariano Monzo 
Published: June 2013

BackgroundThe prevention, diagnosis, and management of noncontact musculoskeletal soft tissue injuries (NCMSTI) related to participation in sport are key components of sport and exercise medicine physician. Epidemiological data have demonstrated the existence of interindividual differences in NCMSTI severity indicating that those injuries occur as a consequence of a combination of both, extrinsic and intrinsic factors, including genetic variations.MethodologyWe examined 8 single nucleotide polymorphisms (SNPs) in the following genes (ELN, TTN, SOX15, IGF2, CCL2, COL1A1, COL5A1 and TNC) related to tissue recovery and tissue repair in a total of 73 elite european football players population from white, black-african and hispanic origin and, at the same time, we have collected NCMSTI suffered by these population during three consecutive seasons. Finally we have correlated results with type, degree and recovery time in injuries collected and then with the distribution of injuries in the three studied populations.Results242 injuries were recorded (203 were muscle, 24 were ligament, and 15 were tendon). The degree of muscle injury was related to IGF2 (P=0.032). Moreover, we observed a close but non-significant relation between degree of muscle injury and CCL2 (P=0.1) and COL5A1 (P=0.07). We also found a close relation between ELN and degree (P=0.09) and a significant relation between ELN and recovery time (P=0.027) of ligament injuries.The frequency of the SNPs varied among the three sub-groups in the present study (p<0.0001). Our results shown a significant relation between ligament injuries and ELN (p=0.001) and a significant relation between tendinous injuries and ELN (p=0.05) and IGF2 (p=0.05) in white population. Moreover, we have observed a significant relation between muscle injuries and ELN (p=0.032) and IGF2 (p=0.016) in Hispanic population.ConclusionsSNPs study constitutes a new field of investigation in Sports Medicine which will help us to identify individuals with shorter recovery and those with greater risk of injury. Our results are only the pave to demonstrate that these genotyping interracial differences are important when studying injuries and let us to indicate that the genetic profile based on the SNPs can be use to describe, as objectively as possible each individuals injurability risk and may well be a useful tool for football players to receive a more specific treatment and preventive care options.