bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of polypropylene fibers on the bond-slip performance of HSS bars in HPC and UHPC
Authors: Pour Arash K. , Noroozinejad Farsangi Ehsan 
Published: July 2024

To control the structural performance of reinforced concrete (RC) members, enough bonding between rebars and concrete should be provided. Different parameters affect the bond interaction between rebars and concrete. This investigation tends to assess the bonding resistance behaviour of high-strength steel (HSS) bars in concrete considering the effect of two types of concrete: high-performance concrete (HPC) and ultra-high-performance concrete (UHPC). In addition to the type of concrete, the effect of fibers incorporation is measured. For this aim, a total of thirty-six specimens were cast and evaluated. Two diameters (12 mm and 16 mm) and three embedded lengths (1, 2, and 3 times the diameter of rebars) were also used, and the impact of the rebar’s diameter and embedded length on the load-bearing capacity, stress and slip of rebars were examined. To boost the bonding characteristics of reinforcements, three various polypropylene fibres (PF) contents were added: 0%, 0.5% and 1%. A pull-out test was carried out on samples. In addition, the obtained results and previous models proposed by literature have been employed to generate new models to predict the bond-slip characteristics of HSS bars in HPC and UHPC when different PF contents are incorporated. The results showed that the maximum peak of slip between the HSS bars and concrete deteriorated with the utilisation of PF, and this peak declined more for UHPC. Additionally, the load capability of specimens was significantly enhanced when PF were added. Finally, the model suggested in this paper may be used to forecast the ultimate stress and bond-slip characteristics of HSS bars in conventional and PF-reinforced HPC and UHPC, with a good level of correctness with the experimental results.
Prevalence, clinical presentation, and treatment-management of cerebral venous thrombosis associated with spontaneous intracranial hypotension: A combined case-series and systematic literature review approach
Authors: Risi Gaetano , Ducros Anne , van Dokkum Liesjet , Lonjon Nicolas , Marchi Nicola , Villain Max , Costalat Vincent , Cagnazzo Federico 
Published: July 2024

Background Cerebral venous thrombosis (CVT) is a rare complication of spontaneous intracranial hypotension (SIH). Therefore, its correct diagnosis and the corresponding optimal treatment-management identification remains challenging. Methods Over the last 10 years, 300 patients received a definite SIH diagnosis at our stroke center. Through thorough review of the database, we identified all patients with SIH-related CVT. In addition, we performed a systematic literature review including all publications on SIH-related CVT. Results Five out of our 300 SIH patients showed CVT (F/M:2/3, mean age: 51.8 ± 15.7). Through the literature search, 72 additional cases were identified. Overall, the prevalence was 1.3% and main clinical presentations were orthostatic headache, nausea, and vomiting. The CVT was predominantly located at the superior sagittal sinus. Treatment strategies included anticoagulants (ACs) (43%), epidural blood patch (EBP) (19.4%), and combined AC + EBP (33.3%). In our cohort, all but one patient received combined EBP and AC. The mean clinical and radiological follow-up were 2 years and 1.5 years, respectively. Complete clinical recovery was reported in 96% of the cases, whereas 56% showed complete radiological CVT resolution. Among patients without radiological resolution (26.4%), 57% received AC-only, while 43% received combined AC + EBP. Of our five cases, all but one patient received combined AC + EBP. Conclusion The overall prevalence of SIH-related CVT was 1.3%. AC and combined AC + EBP were the most used treatment-management strategies. CVT resolution was more commonly achieved after the combined strategy. Overall, the rate of complete clinical recovery was 96%.
Lap-Shear Performance of Weld-Bonded Mg Alloy and Austenitic Stainless Steel in Three-Sheet Stack-Up
Authors: Manladan Sunusi Marwana , Hamza Mukhtar Fatihu , Ramesh Singh , Luo Zhen 
Published: July 2024

AbstractWith the growing interest in utilizing Mg and austenitic stainless steel (ASS) in the automotive sector, joining them together in three-sheet configuration is inevitable. However, achieving this task presents considerable challenges due to the large differences in their physical, metallurgical and mechanical properties. To overcome these challenges, the feasibility of using weld-bonding to join Mg alloy/ASS/ASS was investigated. The nugget formation, interface characteristics, microstructure and mechanical properties of the joints were investigated. The results show that the connection between the Mg alloy and upper ASS was achieved through the combined effect of the cured adhesive and weld-brazing in the weld zone. On the other hand, a metallurgical bond was formed at the ASS/ASS interface. The Mg nugget microstructure exhibited fine columar grains composed predominantly of primary α-Mg grains along with a eutectic mixture of α-Mg and β-Mg17Al12. The nugget formed at the ASS/ASS interface consisted largely of columnar grains of austenite, with some equiaxed dendritic grains formed at the centerline of the joint. The weld-bonded joints exhibited an average peak load and energy absorption of about 8.5 kN and 17 J, respectively (the conventional RSW joints failed with minimal or no load application). The failure mode of the joints changed with increasing welding current from interfacial failure via the Mg nugget/upper ASS interface to partial interfacial failure (part of the Mg nugget was pulled out of the Mg sheet). Both failure modes were accompanied by cohesive failure in the adhesive zone.
Dynamics Modeling and Parameter Identification for a Coupled-Drive Dual-Arm Nursing Robot
Authors: Lu Hao , Yang Zhiqiang , Zhu Deliang , Deng Fei , Guo Shijie 
Published: July 2024

AbstractA dual-arm nursing robot can gently lift patients and transfer them between a bed and a wheelchair. With its lightweight design, high load-bearing capacity, and smooth surface, the coupled-drive joint is particularly well suited for these robots. However, the coupled nature of the joint disrupts the direct linear relationship between the input and output torques, posing challenges for dynamic modeling and practical applications. This study investigated the transmission mechanism of this joint and employed the Lagrangian method to construct a dynamic model of its internal dynamics. Building on this foundation, the Newton-Euler method was used to develop a dynamic model for the entire robotic arm. A continuously differentiable friction model was incorporated to reduce the vibrations caused by speed transitions to zero. An experimental method was designed to compensate for gravity, inertia, and modeling errors to identify the parameters of the friction model. This method establishes a mapping relationship between the friction force and motor current. In addition, a Fourier series-based excitation trajectory was developed to facilitate the identification of the dynamic model parameters of the robotic arm. Trajectory tracking experiments were conducted during the experimental validation phase, demonstrating the high accuracy of the dynamic model and the parameter identification method for the robotic arm. This study presents a dynamic modeling and parameter identification method for coupled-drive joint robotic arms, thereby establishing a foundation for motion control in humanoid nursing robots.
Studies on the thermal sensitivity of lung cancer cells exposed to an alternating magnetic field and magnesium-doped maghemite nanoparticles
Authors: Sikorska Malgorzata , Domanski Grzegorz , Bamburowicz-Klimkowska Magdalena , Kasprzak Artur , Nowicka Anna M. , Ruzycka-Ayoush Monika , Grudzinski Ireneusz P. 
Published: July 2024

Abstract
Background
Magnetic fluid hyperthermia (MFH) represents a promising therapeutic strategy in cancer utilizing the heating capabilities of magnetic nanoparticles when exposed to an alternating magnetic field (AMF). Because the efficacy and safety of MFH treatments depends on numerous intrinsic and extrinsic factors, therefore, the proper MFH setups should focus on thermal energy dosed into the cancer cells.

Methods
In this study, we performed MFH experiments using human lung cancer A549 cells (in vitro) and NUDE Balb/c mice bearing human lung (A549) cancer (in vivo). In these two experimental models, the heat was induced by magnesium-doped iron(III) oxide nanoparticles coated with mPEG-silane (Mg0.1-γ-Fe2O3(mPEG-silane)0.5) when exposed to an AMF.

Results
We observed that the lung cancer cells treated with Mg0.1-γ-Fe2O3(mPEG-silane)0.5 (0.25 mg·mL−1) and magnetized for 30 min at 14.4 kA·m−1 yielded a satisfactory outcome in reducing the cell viability up to ca. 21% (in vitro). The activation energy calculated for this field strength was estimated for 349 kJ·mol−1. Both volumetric measurements and tumor mass assessments confirmed by magnetic resonance imaging (MRI) showed a superior thermal effect in mice bearing human lung cancer injected intratumorally with Mg0.1-γ-Fe2O3(mPEG-silane)0.5 nanoparticles (3 mg·mL−1) and subjected to an AMF (18.3 kA·m−1) for 30 min four times at weekly intervals. Research demonstrated that mice undergoing MFH exhibited a marked suppression of tumor growth (V = 169 ± 94 mm3; p < 0.05) in comparison to the control group of untreated mice. The CEM43 (cumulative number of equivalent minutes at 43 °C) value for these treatments were estimated for ca. 9.6 min with the specific absorption rate (SAR) level ranging from 100 to 150 W·g−1.

Conclusions
The as-obtained results, both cytotoxic and those related to energy calculations and SAR, may contribute to the advancement of thermal therapies, concurrently indicating that the proposed magnetic fluid hyperthermia holds a great potential for further testing in the context of medical applications.

Graphical Abstract
Putative new combination vaccine candidates identified by reverse vaccinology and genomic approaches to control enteric pathogens
Authors: Mikaeel Saeed , Doosti Abbas , Sharifzadeh Ali 
Published: July 2024

Abstract
Objectives
The pathogenic microorganisms that cause intestinal diseases can significantly jeopardize people's health. Currently, there are no authorized treatments or vaccinations available to combat the germs responsible for intestinal disease.

Methods
Using immunoinformatics, we developed a potent multi-epitope Combination (combo) vaccine versus Salmonella and enterohemorrhagic E. coli. The B and T cell epitopes were identified by performing a conservancy assessment, population coverage analysis, physicochemical attributes assessment, and secondary and tertiary structure assessment of the chosen antigenic polypeptide. The selection process for vaccine development included using several bioinformatics tools and approaches to finally choose two linear B-cell epitopes, five CTL epitopes, and two HTL epitopes.

Results
The vaccine had strong immunogenicity, cytokine production, immunological properties, non-toxicity, non-allergenicity, stability, and potential efficacy against infections. Disulfide bonding, codon modification, and computational cloning were also used to enhance the stability and efficacy of expression in the host E. coli. The vaccine's structure has a strong affinity for the TLR4 ligand and is very durable, as shown by molecular docking and molecular modeling. The results of the immunological simulation demonstrated that both B and T cells had a heightened response to the vaccination component.

Conclusions
The comprehensive in silico analysis reveals that the proposed vaccine will likely elicit a robust immune response against pathogenic bacteria that cause intestinal diseases. Therefore, it is a promising option for further experimental testing.
Prediction of suitable regions of wild tomato provides insights on domesticated tomato cultivation in China
Authors: Liu Ping , Xie Ruohan , Xin Guorong , Sun Yufei , Su Shihao 
Published: July 2024

AbstractClimate change is one of the biggest challenges to the world at present. Tomato is also suffered from devastating yield loss due to climate change. The domesticated tomato (Solanum lycopersicum) is presumed to be originated from the wild tomato (S. pimpinellifolium). In this study, we compared the climate data of S. pimpinellifollium with the domesticated tomato, predicted the suitable regions of S. pimpinellifollium in China using MaxEnt model and assessed their tolerance to drought stress. We found that the predicted suitable regions of wild tomato are highly consistent with the current cultivated regions of domesticated tomato, suggesting that the habitat demand of domesticated tomato descended largely from its ancestor, hence the habitat information of wild tomato could provide a reference for tomato cultivation. We further predicted suitable regions of wild tomato in the future in China. Finally, we found that while average drought tolerance between wild and domesticated tomato accessions shows no difference, tolerance levels among wild tomato accessions exhibit higher variation, which could be used for future breeding to improve drought resistance. To summarize, our study shows that suitable regions of wild tomato provide insights into domesticated tomato cultivation in China.
DTG + 3TC dual therapy for the treatment Naïve patients with viral load exceeding 500,000 copies/mL: a retrospective study
Authors: Dou Yanyun , Liao Guangfu , Lu Ruichao , Su Lingsong , Lan Ke , Meng Zhihao , Qin Shanfang , Huang Wei , Xu Yuanlong , Lv Yu , Wen Yuhong , Lan Shuanglai , Zuo Yong , Zhang Yong 
Published: July 2024

Abstract
Background
Antiretroviral therapy (ART) has transformed HIV management, with various regimens available. Dolutegravir (DTG) plus lamivudine (3TC) dual therapy is now the one of the first line regimens.

Methods
A retrospective, observational study included treatment naïve people living with HIV (PLWH) with baseline HIV RNA viral load (VL) greater than 500,000 copies/mL from March 2020 to June 2022. PLWH on DTG + 3TC were included in the 2DR group, while others on INSTI-based three-drug regimens were divided in the 3DR group. Viral suppression, immunological recovery, and safety were assessed.

Results
The study included 52 PLWH, with no significant baseline differences. Virologic suppression rates at weeks 24 and 48 were similar in both groups, even with baseline HIV RNA VL greater than 1,000,000 copies/mL. CD4 + T cell counts improved rapidly. No serious adverse effects were reported.

Conclusions
DTG + 3TC dual therapy demonstrates effectiveness in treatment naïve PLWH with high baseline HIV RNA VL, suggesting its potential as a first line regimen for all treatment naïve PLWH.
Impact of ‘decision-to-delivery’ interval on maternal and perinatal outcomes: a retrospective study of emergency caesarean section from 2017 to 2021 at a secondary health facility in Nigeria
Authors: Abdulbaki Mariam , Aliyu Fullaila O , Ayinde Musa , Issa Amudalat , Adeniran Abiodun S , Ibrahim Olayinka R 
Published: July 2024

Abstract
Background
The decision-to-delivery interval (DDI) for a caesarean section is among the factors that reflect the quality of care a pregnant woman receives and the impact on maternal and foetal outcomes and should not exceed 30 min especially for Category 1 National Institute for Health and Care Excellence (NICE) guidelines. Herein, we evaluated the effect of decision-to-delivery interval on the maternal and perinatal outcomes among emergency caesarean deliveries at a secondary health facility in north-central Nigeria.

Methods
We conducted a four-year retrospective descriptive analysis of all emergency caesarean sections at a secondary health facility in north-central Nigeria. We included pregnant mothers who had emergency caesarean delivery at the study site from February 10, 2017, to February 9, 2021.

Results
Out of 582 who underwent an emergency caesarean section, 550 (94.5%) had a delayed decision-to-delivery interval. The factors associated with delayed decision-to-delivery interval included educational levels (both parents), maternal occupation, and booking status. The delayed decision-to-delivery interval was associated with an increase in perinatal deaths with an odds ratio (OR) of 6.9 (95% CI, 3.166 to 15.040), and increased odds of Special Care Baby Unit (SCBU) admissions (OR 9.8, 95% CI 2.417 to 39.333). Among the maternal outcomes, delayed decision-to-delivery interval was associated with increased odds of sepsis (OR 4.2, 95% CI 1.960 to 8.933), hypotension (OR 3.8, 95% 1.626 TO 9.035), and cardiac arrest (OR 19.5, 95% CI 4.634 to 82.059).

Conclusion
This study shows a very low optimum DDI, which was associated with educational levels, maternal occupation, and booking status. The delayed DDI increased the odds of perinatal deaths, SCBU admission, and maternal-related complications.
Prenatal phenotypes and pregnancy outcomes of fetuses with 16p11.2 microdeletion/microduplication
Authors: Yue Fagui , Hao Mengzhe , Jiang Dandan , Liu Ruizhi , Zhang Hongguo 
Published: July 2024

Abstract
Background
Chromosomal 16p11.2 deletions and duplications are genomic disorders which are characterized by neurobehavioral abnormalities, obesity, congenital abnormalities. However, the prenatal phenotypes associated with 16p11.2 copy number variations (CNVs) have not been well characterized. This study aimed to provide an elaborate summary of intrauterine phenotypic features for these genomic disorders.

Methods
Twenty prenatal amniotic fluid samples diagnosed with 16p11.2 microdeletions/microduplications were obtained from pregnant women who opted for invasive prenatal testing. Karyotypic analysis and chromosomal microarray analysis (CMA) were performed in parallel. The pregnancy outcomes and health conditions of all cases after birth were followed up. Meanwhile, we made a pooled analysis of the prenatal phenotypes in the published cases carrying 16p11.2 CNVs.

Results
20 fetuses (20/20,884, 0.10%) with 16p11.2 CNVs were identified: five had 16p11.2 BP2-BP3 deletions, 10 had 16p11.2 BP4-BP5 deletions and five had 16p11.2 BP4-BP5 duplications. Abnormal ultrasound findings were recorded in ten fetuses with 16p11.2 deletions, with various degrees of intrauterine phenotypic features observed. No ultrasound abnormalities were observed in any of the 16p11.2 duplications cases during the pregnancy period. Eleven cases with 16p11.2 deletions terminated their pregnancies. For 16p11.2 duplications, four cases gave birth to healthy neonates except for one case that was lost to follow-up.

Conclusions
Diverse prenatal phenotypes, ranging from normal to abnormal, were observed in cases with 16p11.2 CNVs. For 16p11.2 BP4-BP5 deletions, abnormalities of the vertebral column or ribs and thickened nuchal translucency were the most common structural and non-structural abnormalities, respectively. 16p11.2 BP2-BP3 deletions might be closely associated with fetal growth restriction and single umbilical artery. No characteristic ultrasound findings for 16p11.2 duplications have been observed to date. Given the variable expressivity and incomplete penetrance of 16p11.2 CNVs, long-term follow-up after birth should be conducted for these cases.
Neoadjuvant inetetamab and pertuzumab with taxanes and carboplatin (TCbIP) In locally advanced HER2-positive breast cancer: a prospective cohort study with propensity-matched analysis
Authors: Jiang Mingxia , Chai Yue , Liu Jiaxuan , He Maiyue , Wang Yipeng , Yang Xue , Xing Zeyu , Zhang Mengqi , Zhou Shihan , Ma Fei , Wang Jiayu , Yuan Peng , Xu Binghe , Li Qiao 
Published: July 2024

Abstract
Background
Inetetamab is the first domestically developed innovative anti-HER2 monoclonal antibody in China, proven effective and safe in HER2-positive advanced breast cancer. However, its efficacy and safety in neoadjuvant treatment of HER2-positive locally advanced breast cancer (LABC) remain to be validated.

Methods
This prospective cohort study aimed to evaluate the efficacy and safety of inetetamab combined with pertuzumab, taxanes, and carboplatin (TCbIP) in neoadjuvant therapy for HER2-positive LABC, comparing it to data from patients treated with the TCbHP regimen (trastuzumab combined with pertuzumab, taxanes, and carboplatin) using propensity score matching (PSM). The primary endpoint was total pathological complete response (tpCR). Adverse events (AEs), objective response rate (ORR), and near-pCR were key secondary endpoints.

Results
Forty-four patients with clinical stage IIA-IIIC HER2-positive LABC were prospectively enrolled and treated with the TCbIP regimen. The tpCR rate among 28 patients who completed surgery was 60.7%, comparable to and slightly higher than the TCbHP group in PSM (60.7% vs. 53.6%, P = 0.510). The ORR was 96.4%, and the DCR reached 100.0%. The most common ≥ grade 3 AE was neutropenia (21.4% vs. 11.9%, P = 0.350). No significant reduction in left ventricular ejection fraction was observed, and no patient withdrew from treatment due to AEs.

Conclusion
Neoadjuvant therapy with TCbIP showed good efficacy and safety in patients with HER2-positive LABC and might be another promising option for neoadjuvant treatment.

Trial registration
NCT05749016 (registration date: Nov 01, 2021).
Comparison of rebubbling rate between preloaded endothelium-in and preloaded no-touch endothelium-out Descemet membrane endothelial keratoplasty transplantation
Authors: Kronschläger Martin , Ruzza Alessandro , Zeilinger Johannes , Schlatter Andreas , Ruiss Manuel , Findl Oliver 
Published: July 2024

Abstract
Background
To compare the difference in rebubbling rates between patients undergoing Descemet membrane endothelial keratoplasty (DMEK) with endothelium-in using a standard IOL cartridge and those with endothelium-out DMEK utilizing a no-touch technique with borosilicate glass cartridge transplantation.

Methods
This retrospective study included all eyes that underwent preloaded endothelium-in or endothelium-out DMEK transplantation from June 2019 to December 2023 at the Hanusch Hospital, Vienna, Austria. All DMEKs were harvested, prepared and preloaded at the European Eye Bank of Venice, Italy. DMEK surgeries were done by one experienced surgeon and the procedure was completed by air tamponade of the anterior chamber.

Results
Overall, 32 eyes each of 31 endothelium-out patients and of 29 endothelium-in patients were included. 32 preloaded endothelium-in procedures were followed by 32 preloaded endothelium-out procedures. Rebubbling rate for endothelium-in was 15/32 (47%) and for endothelium-out was 7/25 (28%) (p = 0.035, Pearson’s chi-squared test). Donor age was the most important variable for rebubbling in a random forest algorithm model (ROC: 0.69).

Conclusions
Rebubbling rate in endothelium-out DMEK was less than two-thirds compared to endothelium-in DMEK favoring no-touch endothelium-out DMEK as the preferred technique of DMEK transplantation.