bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isocitrate dehydrogenase 2 mutation is a frequent event in osteosarcoma detected by a multi‐specific monoclonal antibody MsMab‐1
Authors: Liu Xing , Kato Yukinari , Kaneko Mika Kato , Sugawara Masato , Ogasawara Satoshi , Tsujimoto Yuta , Naganuma Yasushi , Yamakawa Mitsunori , Tsuchiya Takashi , Takagi Michiaki 
Published: October 2013

AbstractSomatic mutations of isocitrate dehydrogenase (IDH) 1 and IDH2 occur in gliomas, acute myeloid leukemia, and cartilaginous tumors. Somatic mosaic IDH1/2 mutations are also reported in Ollier disease and Maffucci syndrome, which are characterized by multiple central cartilaginous tumors. Although IDH1/2 mutation analysis against osteosarcoma has been performed in several studies, no IDH1/2 mutation has been reported. Herein, we newly report the IDH2‐R172S mutation in three of 12 (25%) osteosarcoma patients, which was detected by direct DNA sequencing. No monoclonal antibody (mAb) has been reported against IDH2‐R172S mutation. However, we demonstrate that the IDH2‐R172S peptide was recognized by our established multi‐specific anti‐mutated IDH1/2 mAb, MsMab‐1, in enzyme‐linked immunosorbent assay. Western blot analysis revealed that MsMab‐1 reacts with PA tag combined recombinant proteins of IDH2‐R172S. Furthermore, MsMab‐1 stained IDH2‐R172S‐expressing osteosarcoma tissues in immunohistochemistry. The MsMab‐1 stained nine of 32 (28.1%) osteosarcomas in a tissue microarray. This report is the first describing IDH2 mutations in osteosarcoma, which can be detected by MsMab‐1 mAb. Taken together, these results show that MsMab‐1 can be anticipated for use in immunohistochemical determination of IDH1/2 mutation‐bearing osteosarcoma.
EasyHome: an online virtual home decoration system
Authors: Zhang Mingmin , Pan Zhigeng , Huang Xixi , Xiang Nan , Wang Shuwen , Zhu Pengyu 
Published: October 2013

ABSTRACTThis paper provides an online virtual 7home decoration system, which integrates web interaction technique into virtual home decoration. The main functions of this system include house design, house decoration, and data management. For the house design, an automatic joint method of the walls is proposed, in order to design various house. For the house decoration, we introduce the wall decoration principle corresponding to the algorithm of discretization on the walls, which contains doors or windows, and triangularization on the irregular floors. To variety of different textures and collage regulations, we provide a new texture collage mapping method. Technology of rendering to texture is used to generate a small geometry texture, which will be mapped into a large target object on the basis of the texture's structural properties. As a result, the whole texture continuity is also maintained. In data management aspect, we embed a browser into this system so that users can conveniently obtain decoration models on the basis of web interaction. After these models have been downloaded, they can be shown in virtual scene according to guide information. In addition, some quotation lists can be generated automatically. Experimental results show that an authentic house can be easily presented in our system. Copyright © 2013 John Wiley & Sons, Ltd.
Multiscale Entropy Analysis of Instantaneous Pressure Fluctuation in a Novel Jet Tank
Authors: Meng H. , Wang F. , Yu Y. , Wang Y. , Wu J. 
Published: October 2013

AbstractSample entropy (SampEn) and intrinsic mode entropy (IMEn) are used to evaluate the fluctuation characteristics in a novel circulating jet tank (CJT). SampEn analysis indicates that the fluctuation complexity of intrinsic mode functions (IMF) reaches a maximum in the first scale and then decreases with the increase of the decomposed scales. When the frequency bands are less than 36.25 Hz, the fluctuation complexity of the IMF gradually increases with increasing Reynolds numbers. The IMEn of IMF with different cumulative scales decreases and then increases with increasing Re. The IMEn of pressure fluctuations is dominated by the functions IMF1 to IMF4. IMF5 to IMF7 start to play a more important role in the fluctuation characteristics for Re > 29 280.
The Electronic Nature of the 1,4‐β‐Glycosidic Bond and Its Chemical Environment: DFT Insights into Cellulose Chemistry
Authors: Loerbroks Claudia , Rinaldi Roberto , Thiel Walter 
Published: October 2013

AbstractThe molecular understanding of the chemistry of 1,4‐β‐glucans is essential for designing new approaches to the conversion of cellulose into platform chemicals and biofuels. In this endeavor, much attention has been paid to the role of hydrogen bonding occurring in the cellulose structure. So far, however, there has been little discussion about the implications of the electronic nature of the 1,4‐β‐glycosidic bond and its chemical environment for the activation of 1,4‐β‐glucans toward acid‐catalyzed hydrolysis. This report sheds light on these central issues and addresses their influence on the acid hydrolysis of cellobiose and, by analogy, cellulose. The electronic structure of cellobiose was explored by DFT at the BB1 K/6‐31++G(d,p) level. Natural bond orbital (NBO) analysis was performed to grasp the key bonding concepts. Conformations, protonation sites, and hydrolysis mechanisms were examined. The results for cellobiose indicate that cellulose is protected against hydrolysis not only by its supramolecular structure, as currently accepted, but also by its electronic structure, in which the anomeric effect plays a key role.
Sustainability, Governance and Time: Exploring ‘Critical Junctures’ in the Governance of Genetically Modified Organisms in France
Authors: McCauley Darren 
Published: October 2013

ABSTRACTThe issue of time, most associated with intergenerational justice, is an integral component of the sustainable development agenda. And yet, research in this area from a governance perspective remains strangely cross‐sectional in nature. This paper seeks to contribute to our understanding of time by analysing the impact of transformative events across the development of governance practices. Sustainable development is conceptualized in this paper as a serious challenge for governance structures and processes in nation states over time. Global and European agreements have placed the inclusion of civil society actors in policy‐making at the heart of the sustainability agenda. In contrast, there is a clear mismatch between these principles of civil society inclusion and policy‐making in France. This paper assesses the implementation of sustainable development as civil society inclusion with reference to the French experience in dealing with genetically modified organisms policy. It is argued that ‘sustainable governance’ must embrace a more comprehensive understanding of ‘change over time’. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment.
Amino‐Containing Ultrafine Organosilica‐Nanoparticle‐Modified Au Electrode for the Determination of Cu(II) Ions
Authors: Wu Zhongwei , Liao Jinjin , Xiao Jianlin , Liu Jianyun , Yang Jianmao , Zhou Xin , Xin Meng 
Published: October 2013

AbstractUsing 3‐Aminopropyltriethoxysilane(APTES) as a single silica source, an amino‐rich ultrafine organosilica‐nanoparticle‐modified Au electrode was fabricated, following the formation of (3‐mercaptopropyl)‐trimethoxysilane (MPTS) monolayer on Au surface (MPTS/Au). With cetyltrimethylammonium bromide as an additive, APTES‐based gel particles on the electrode have a narrow particle size distribution of 4–7 nm and “crystal‐like” structure. AFM and electrochemical characterization confirmed the successful grafting of APTES nanoparticles on MPTS/Au. The APTES/MPTS/Au electrode is highly sensitive for the detection of copper(II) ions with a detection limit as low as 1.6×10−12 mol L−1 (S/N>3) by square wave voltammetry. The current is linear to copper(II) concentration between 1.6×10−12 and 6.25×10−10 mol L−1.
Transient sediment supply in a high‐altitude Alpine environment evidenced through a 10Be budget of the Etages catchment (French Western Alps)
Authors: Delunel Romain , van der Beek Peter A. , Bourlès Didier L. , Carcaillet Julien , Schlunegger Fritz 
Published: October 2013

ABSTRACTAlthough beryllium‐10 (10Be) concentrations in stream sediments provide useful synoptic views of catchment‐wide erosion rates, little is known on the relative contributions of different sediment supply mechanisms to the acquisition of their initial signature in the headwaters. Here we address this issue by conducting a 10Be‐budget of detrital materials that characterize the morphogenetic domains representative of high‐altitude environments of the European Alps. We focus on the Etages catchment, located in the Ecrins‐Pelvoux massif (southeast France), and illustrate how in situ 10Be concentrations can be used for tracing the origin of the sand fraction from the bedload in the trunk stream. The landscape of the Etages catchment is characterized by a geomorphic transient state, high topographic gradients, and a large variety of modern geomorphic domains ranging from glacial environments to scarcely vegetated alluvial plains. Beryllium‐10 concentrations measured in the Etages catchment vary from ~1 × 104 to 4.5 × 105 atoms per gram quartz, while displaying consistent 10Be signatures within each representative morphogenetic unit. We show that the basic requirements for inferring catchment‐wide denudation from 10Be concentration measurements are not satisfied in this small, dynamic catchment. However, the distinct 10Be signature observed for the geomorphic domains can be used as a tracer. We suggest that a terrestrial cosmogenic nuclide (TCN) budget approach provides a valuable tool for the tracing of material origin in basins where the ‘let nature do the averaging’ principles may be violated. Copyright © 2013 John Wiley & Sons, Ltd.
Enhanced rock‐slope failure following ice‐sheet deglaciation: timing and causes
Authors: Ballantyne Colin K. , Wilson Peter , Gheorghiu Delia , Rodés Àngel 
Published: October 2013

ABSTRACTThe temporal pattern of rock‐slope failures (RSFs) following Late Pleistocene deglaciation on tectonically stable terrains is controversial: previous studies variously suggest (1) a rapid response due to removal of supporting ice (‘debuttressing’), (2) a progressive decline in RSF frequency, and (3) a millennial‐scale delay before peak RSF activity. We test these competing models through beryllium‐10 (10Be) exposure dating of five closely‐spaced quartzite RSFs on the Isle of Jura, Scotland, to establish the relationship between timing of failure and those of deglaciation, episodes of rapid warming and periods of rapid glacio‐isostatic uplift. All five dated RSFs occurred at least 720–2240 years after deglaciation, with the probability of failure peaking ~2 ka after deglaciation, consistent with millennial‐scale delay model (3). This excludes debuttressing as an immediate cause of failure, though it is likely that time‐dependent stress release due to deglacial unloading resulted in progressive development of failure planes within the rock. Thaw of permafrost ice in joints is unlikely to have been a prime trigger of failure as some RSFs occurred several centuries after the onset of interstadial warming. Conversely, the timespan of the RSFs coincides with the period of maximum glacio‐isostatic crustal uplift, suggesting that failure was triggered by uplift‐driven seismic events acting on fractured rock masses. Implications of this and related research are: (1) that retreat of the last Pleistocene ice sheets across tectonically‐stable mountainous terrains was succeeded by a period of enhanced rock‐slope failure due to deglacial unloading and probably uplift‐driven seismicity; (2) that the great majority of RSFs in the British Isles outside the limits of Loch Lomond Stadial (= Younger Dryas) glaciation are of Lateglacial (pre‐Holocene) age; and (3) numerous RSFs must also have occurred inside Loch Lomond Stadial (LLS) glacial limits, but that runout debris was removed by LLS glaciers. Copyright © 2013 John Wiley & Sons, Ltd.
On the use of Attribute‐Based Encryption for multimedia content protection over Information‐Centric Networks
Authors: Papanis John P. , Papapanagiotou Stavros I. , Mousas Aziz S. , Lioudakis Georgios V. , Kaklamani Dimitra I. , Venieris Iakovos S. 
Published: October 2013

ABSTRACTVideo streaming dominates the Internet traffic, a trend that is expected to increase in the next years. End users expect to access video content, regardless of their device, connection type and location. On the other hand, content providers set strict security requirements regarding the protection of their content, making up an overall difficult and challenging context for Over‐the‐Top service providers. A miscellany of proprietary approaches tries to address these issues, providing, however, only partial solutions, and composing a domain, highly fragmented by non‐interoperable products. In this paper, we propose an architecture that utilises Information‐Centric Networking (ICN) in order to provide scalable and efficient video distribution, and Attribute‐Based Encryption (ABE) to securely distribute this content in the ICN environment. ABE is incorporated into Digital Rights Management (DRM) schemes. We present the video license acquisition process, with a focus on orchestrating multiple authorities; subsequently, the video distribution over ICN is demonstrated, and finally, we investigate user revocation techniques in the ABE and ICN context and adopt the most appropriate one. Copyright © 2013 John Wiley & Sons, Ltd.
Are Your Check Transactions Secure Enough?
Authors: McGee Jo Ann , Byington J. Ralph 
Published: October 2013

AbstractCash misappropriations—which include currency, checks, and money orders—is the most common target of white‐collar criminals. And check tampering is one of their most common methods. This article explains the different types of check tampering schemes that dishonest employees use—and how to prevent and detect them. © 2013 Wiley Periodicals, Inc.
Managing Euro FX Risk With Benchmark Data
Authors: Makar Stephen , Wang Li 
Published: October 2013

AbstractPrompted by the financial crisis, central banks have offered unprecedented support for the global economy since 2007. But a primary concern of treasurers remains: How do you manage euro foreign exchange (FX) risk? So treasurers worry about the uncertainties: When and how will monetary policy be normalized? How will FX rates respond? And what information is needed to manage the accompanying FX risk prudently? The authors of this article help readers by providing benchmark data pertaining to euro FX risk management. They also explore the strategic implications of the data. © 2013 Wiley Periodicals, Inc.
Morphological and quantitative evaluation of the ovarian recrudescence in Nile tilapia (Oreochromis niloticus) after spawning in captivity
Authors: Melo Rafael Magno Costa , Martins Yuri Simões , de Alencar Teixeira Edgar , Luz Ronald Kennedy , Rizzo Elizete , Bazzoli Nilo 
Published: October 2013

ABSTRACTThe Nile tilapia is one of the most important fish species for aquaculture worldwide. Understanding their reproductive biology is essential for improving their aquaculture methods. The morphological and quantitative dynamics of ovarian recrudescence of Oreochromis niloticus was studied for 21 days postspawning. To accomplish this, breeding females were kept in controlled conditions and ovarian samples were collected weekly for histological, ultrastructural and morphometric analyses. Ovarian follicle morphology revealed an intense synthesis activity of the follicular cells, which actively contributed to formation of the zona radiata and oocyte development following spawning. Recently spawned ovaries contained follicles at all developmental stages, but they were predominantly early primary growth (∼42%) and full‐grown follicles (∼20%). Remnants of spawning, postovulatory follicle complexes represented approximately 5% of the former ovarian follicles immediately after spawning, and less than 1% after 7 days. Atretic follicles accounted for approximately 2% of the follicles studied during the period. The stock of primary growth follicles was stable during ovarian recrudescence, indicating their availability for continuous recruitment. Only the frequency of full‐grown follicles significantly increased in the ovaries during recrudescence, representing approximately 35% of the follicles 21 days postspawning. The diameters of all follicles were significantly different between the periods analyzed. The ovaries' morphological characteristics, the maintenance of young follicles stocks and the gradual and significant increase in the proportion and diameter of full‐grown follicles showed a rapid ovarian recovery and follicular growth of O. niloticus, in 21 days at 29.5°C, necessary for the next spawning. J. Morphol. 275:348–356, 2014. © 2013 Wiley Periodicals, Inc.
Common solutions to resolve different dietary challenges in the ruminant dentition: The functionality of bovid postcanine teeth as a masticatory unit
Authors: Gailer Juan Pablo , Kaiser Thomas M. 
Published: October 2013

ABSTRACTPlasticity of tooth shape in mammals is of great adaptive value for the efficient exploitation of specific feeding niches and is a crucial mechanism for ecological diversification. In this study, we aimed to infer chewing effectiveness from the functional shape of different postcanine teeth within bovids, the most diverse extant group of large herbivorous mammals. We consider the postcanine dentition as a masticatory unit and test for differences related to food biomechanical properties, dietary abrasiveness, and chewing dynamics. We compare functional properties of the postcanine tooth row among species with well‐known dietary strategies by integrating digitalization of high‐resolution occlusal surface 3D‐models of upper postcanine dentitions and quantification of the indentation index (D), a structural parameter representing enamel complexity. We test for differences in the occlusal shape among tooth positions in the postcanine dentition using robust, heteroscedastic tests in a one‐way analysis of variance. Our results show three distinct patterns of enamel complexity along the tooth row: (1) D is more homogeneously distributed among tooth positions; (2) D increases gradually in the mesiodistal axis along the tooth row; and (3) D increases abruptly only at the transition between premolars and molars. We interpreted these patterns as different adaptive configurations of the postcanine tooth row relating to diet. Grass‐ and fruit‐eating bovids show the same abrupt increase in enamel complexity at the transition from premolars to molars. Intermediate feeding and leaf‐browsing species show the same gradual, mesiodistal increase in complexity along the tooth row. The absolute physical dietary resistance (biomechanical properties plus abrasiveness) and its relation to mechanical constraints of the chewing stroke are the likely selective factors leading to convergence of enamel complexity patterns along the tooth row among taxa with different diets. J. Morphol. 275:328–341, 2014. © 2013 Wiley Periodicals, Inc.
Comparison of elevation and remote sensing derived products as auxiliary data for climate surface interpolation
Authors: Alvarez Otto , Guo Qinghua , Klinger Robert C , Li Wenkai , Doherty Paul 
Published: October 2013

ABSTRACTClimate models may be limited in their inferential use if they cannot be locally validated or do not account for spatial uncertainty. Much of the focus has gone into determining which interpolation method is best suited for creating gridded climate surfaces, which often a covariate such as elevation (Digital Elevation Model, DEM) is used to improve the interpolation accuracy. One key area where little research has addressed is in determining which covariate best improves the accuracy in the interpolation. In this study, a comprehensive evaluation was carried out in determining which covariates were most suitable for interpolating climatic variables (e.g. precipitation, mean temperature, minimum temperature, and maximum temperature). We compiled data for each climate variable from 1950 to 1999 from approximately 500 weather stations across the Western United States (32° to 49° latitude and −124.7° to −112.9° longitude). In addition, we examined the uncertainty of the interpolated climate surface. Specifically, Thin Plate Spline (TPS) was used as the interpolation method since it is one of the most popular interpolation techniques to generate climate surfaces. We considered several covariates, including DEM, slope, distance to coast (Euclidean distance), aspect, solar potential, radar, and two Normalized Difference Vegetation Index (NDVI) products derived from Advanced Very High Resolution Radiometer (AVHRR) and Moderate Resolution Imaging Spectroradiometer (MODIS). A tenfold cross‐validation was applied to determine the uncertainty of the interpolation based on each covariate. In general, the leading covariate for precipitation was radar, while DEM was the leading covariate for maximum, mean, and minimum temperatures. A comparison to other products such as PRISM and WorldClim showed strong agreement across large geographic areas but climate surfaces generated in this study (ClimSurf) had greater variability at high elevation regions, such as in the Sierra Nevada Mountains.
Snow cover trend analysis using Interactive Multisensor Snow and Ice Mapping System data over Turkey
Authors: Sönmez Ibrahim , Tekeli Ahmet Emre , Erdi Erdem 
Published: October 2013

ABSTRACTThe daily snow cover data from Interactive Multisensor Snow and Ice Mapping System (IMS) by National Oceanic and Atmospheric Administration's National Environmental Satellite Data and Information Service (NOAA/NESDIS) covering the 2004–2012 time period is used in this study. In the first part of the study, daily IMS product is validated over Turkey using daily ground truth snow depth measurements from 219 climatological and synoptic sites. The categorical statistics of probability of detection (POD) and false alarm rates (FAR) are provided both for whole Turkey and with respect to geographical sub‐regions. The overall POD and FAR amounts for Turkey are obtained as 73.55 and 25.11%, respectively. The performed analysis indicates an increase in IMS accuracies as the snowpack depth at the stations increase. In the second part of the study, the nonparametric Mann‐Kendall test is performed to analyse the snow cover trend over Turkey with respect to sub‐regions considering the whole year and each season separately. A negative trend in snow‐covered area percentage is obtained for Turkey at the significance level of α = 0.05. From the seasonal perspective for Turkey, negative trend for spring and summer seasons, positive trend for autumn season and combination of negative and no trend for winter season are obtained at the same significance level. Almost the same results are valid for the sub‐regions with some local and seasonal variations.