bluuebunny/crossref_metadata_2025_split huggingface dataset:
UGT1A1 genotype and irinotecan therapy: general review and implementation in routine practice
Authors: Etienne‐Grimaldi Marie‐Christine , Boyer Jean‐Christophe , Thomas Fabienne , Quaranta Sylvie , Picard Nicolas , Loriot Marie‐Anne , Narjoz Céline , Poncet Delphine , Gagnieu Marie‐Claude , Ged Cécile , Broly Franck , Le Morvan Valérie , Bouquié Régis , Gaub Marie‐Pierre , Philibert Laurent , Ghiringhelli François , Le Guellec Chantal ,   Collective work by the Groupe de Pharmacologie Clinique Oncologique (GPCO‐Unicancer) and the French Réseau National de Pharmacogénétique Hospitalière (RNPGx)
Published: March 2015

AbstractIrinotecan is a major drug in the treatment of advanced colorectal cancer. Its active form is the SN38 metabolite, which is cleared by the biliary route after glucuronidation by uridine diphosphate–glucuronosyltransferase 1A1 (UGT1A1). UGT1A1 activity exhibits a wide intersubject variability, in part related to UGT1A1 gene polymorphisms. The present review on the impact of the deficient UGT1A1*28 variant on irinotecan efficacy and toxicity was produced by a French joint workgroup comprising the Group of Clinical Onco‐pharmacology (GPCO‐Unicancer) and the National Pharmacogenetics Network (RNPGx). It clearly emerges that for irinotecan doses at least equal to 180 mg/m2, patients homozygous for the UGT1A1*28 allele are at increased risk of developing hematological and/or digestive toxicities. Irinotecan dose reduction is thus recommended in homozygous *28/*28 patients. In addition, this personalized medicine strategy aims to secure high‐dose irinotecan administration (≥240 mg/m2) that have proven to be safe in homozygous *1/*1 patients only. The clinical relevance of this test is discussed in terms of treatment efficacy improvement, as increasing the irinotecan dose appears to be safe in patients not bearing a deficient allele. Best execution practices, cost‐effectiveness, and result interpretation are discussed with the aim of facilitating the implementation of this analysis in clinical practice. The existence of networks of laboratories performing this test in routine hospital treatment, as in France, offers the prospect of widespread screening, thus guaranteeing equal access to safe treatment and optimized therapy for patients receiving irinotecan‐based therapy in advanced colorectal cancer.
Rebamipide suppresses TNF‐α mediated inflammation in vitro and attenuates the severity of dermatitis in mice
Authors: Li Weiwei , Zhao Yunpeng , Xu Xiangling , Ma Weiyuan , Gao Peng , Wang Yan , Liang Ke , Li Ruifeng 
Published: March 2015

Rebamipide is a routine drug for the treatment of gastritis in a clinical setting. Recently, it has been shown to protect against various inflammatory diseases, and has provided a potential therapy for these diseases. However, whether rebamipide has a role in dermatitis remains to be elucidated. Here, we found that rebamipide alleviated the inflammatory reaction induced by tumor necrosis factor‐α in RAW264.7, a stable macrophage cell line. Furthermore, rebamipide treatment repressed activation of nuclear factor‐kappaB signaling, a well‐established inflammatory signaling pathway. Moreover, an oxazolone‐induced dermatitis mouse model was established to investigate the role of rebamipide in vivo. PBS control group exhibited typical skin inflammation, whereas treatment with rebamipide remarkably attenuated a dermatitis phenotype in this mouse model. The protective role of rebamipide in dermatitis in vivo was probably due to its inhibition of nuclear factor‐kappaB signaling. Collectively, rebamipide may represent a promising molecular target for the prevention and treatment of inflammatory skin diseases.
Alcohol, Young People and Urban Life
Authors: Wilkinson Samantha 
Published: March 2015

AbstractMoving beyond the current academic pre‐occupation with the night‐time economy and drinking venues, this paper highlights the specificities of outdoor drinking cultures in streets and parks. Instead of viewing outdoor drinking as morally transgressive – as promoted in the popular press – it is contended that outdoor drinkscapes are distinctly appealing over commercial premises for some young urbanites. Streets and parks enable young people to feel socially and physically unrestricted whilst consuming alcohol; provide a space where young people can drink with friends who are not old enough to consume alcohol in commercial premises; and allow drinkers a chance to consume relatively cheap alcohol. Accounts of young people in urban public spaces are typically one of intergenerational conflict, whereby adults seek to exclude or marginalise young people or, at least, try to control their presence and activities. However, in attempting to understand young people's alcohol consumption experiences in outdoor urban spaces, a series of complex personal geographies emerge in which not only adult–young people relations but also young people–young people relations play an important role. Whilst some progress has been made in exposing the diversity of young people's drinkscapes, it is argued that much of the existing literature renders young people's drinking spaces static, bounded terrains. This paper turns to suggest that the ‘new mobilities paradigm’ can be drawn upon to develop and enrich the geographies of young urbanites' outdoor alcohol consumption experiences. It is argued that the extant literature on alcohol‐related mobilities is predominantly concerned with a ‘pointillist’ understanding of mobility. It is contended that Bissell's () alternative conceptualisation of mobility as a ‘loop’ is a more apt means of capturing the more pointless every night mobilities of many young people; particularly the mobilities of those who are not old enough/choose not to consume alcohol in commercial premises, and choose instead to spend their evenings traversing outdoor drinkscapes. It is also asserted that the embodied, emotional and affective elements of young people's alcohol‐related im/mobilities need to be much more prominent if understandings of the lived experiences of young urbanites' drinking geographies are to be unearthed.
Gentrification, Transit, and Land Use: Moving Beyond Neoclassical Theory
Authors: Revington Nick 
Published: March 2015

AbstractDespite attention to social equity in the way public transit services are distributed, little work has considered how transportation systems may impact social equity through land use changes, particularly gentrification. Existing research on transportation and land use has been grounded primarily in a neoclassical urban economic perspective. However, the neoclassical framework is limited in its ability to handle issues of social justice such as the gentrification process. Meanwhile, critical gentrification literature has seldom considered the potential influence of transport systems to alter the distribution of accessibility benefits within a city. It is argued that a Marxist approach that considers the roles of capital and class in the gentrification process offers a better understanding of how transit infrastructure matters and contributes to a reinvigoration of transport geography. Finally, some directions for future research are suggested.
FOREIGN OR FAMILIAR? MELINDA ABONJI'S AND MARICA BODROŽIC'S MULTILINGUAL LITERATURE
Authors: Förster Kristina 
Published: March 2015

ABSTRACTThis article examines language mixing in the works of two multilingual authors, Melinda Abonji and Marica Bodrožić, who write in their second language, German. I analyse their different techniques of working with language that ultimately lead to a common result: both authors undermine the binaries of native and foreign language, each in her own particular way. Whereas Abonji describes the different associations that a word for the same object evokes in her two languages, thereby connecting and combining the languages in her text, Bodrožić applies German as protection against emotions and clearly separates her two languages, drawing unexpected connections solely between German words. While Abonji's work is exemplary of a literature that promotes ‘Mehrsprachigkeit’ and ‘Vielstimmigkeit’, Bodrožić confronts the German reader with ‘the unknown’ in the German language itself. By focusing on language as the raw material of the texts and by integrating linguistic research on multilingualism, this article grounds the growing interest in this body of work in its writers’ multilingualism.Dieser Essay untersucht die Verbindung verschiedener Sprachen in den Werken zweier mehrsprachiger Autorinnen, Melinda Abonji und Marica Bodrožić, die in ihrer Zweitsprache Deutsch arbeiten. Ich untersuche unterschiedliche Methoden der Sprachmischung, die aber letztendlich zu demselben Ergebnis führen: beide Autorinnen untergraben den binären Gegensatz zwischen Mutter‐ und Fremdsprache. Abonji beschreibt unterschiedliche Assoziationen, die Bezeichnungen in ihren zwei Sprachen für ein und denselben Gegenstand in ihr hervorrufen und verbindet und kombiniert die Sprachen in ihrem Werk. Bodrožić setzt die deutsche Sprache als einen Schutzwall gegen Emotionen ein und trennt ihre Erst‐ und ihre Zweitsprache entschieden voneinander. Ihre Sprachspiele beschränken sich auf die deutsche Sprache allein. Während Abonjis Werk exemplarisch für eine Literatur der ‘Mehrsprachigkeit’ und ‘Vielstimmigkeit’ ist, konfrontiert Bodrožić den deutschen Leser mit dem Unbekannten in der deutschen Sprache selbst. Durch linguistische Forschung zur Mehrsprachigkeit untermauert, zeigt mein Fokus auf das Rohmaterial Sprache, dass die Mehrsprachigkeit der Autoren eine grundlegende Rolle für das wachsende Interesse an ihrer Literatur spielt.
Factor XI replacement for inherited factor XI deficiency in routine clinical practice: results of the HEMOLEVEN prospective 3‐year postmarketing study
Authors: Bauduer F. , de Raucourt E. , Boyer‐Neumann C. , Trossaert M. , Beurrier P. , Faradji A. , Peynet J. , Borg J.‐Y. , Chamouni P. , Chatelanaz C. , Henriet C. , Bridey F. , Goudemand J. ,   the French Postmarketing Study Group
Published: March 2015

SummaryFactor XI (FXI)‐deficient patients may develop excessive bleeding after trauma or surgery. Replacement therapy should be considered in high‐risk situations, especially when FXI levels are below 20 IU dL−1. HEMOLEVEN is a human plasma‐derived factor XI concentrate available in France since 1992, but there are few data regarding its use by physicians. This prospective study assessed the use, efficacy and safety of HEMOLEVEN in common clinical practice. HEMOLEVEN was evaluated in FXI‐deficient patients in 13 French centres in a 3‐year postmarketing study. Forty‐four patients (30 females, 14 males) received 67 treatments. The median age was 37 years (8 months–91 years). Basal FXI levels were <1 to 51 IU dL−1 (median: 5.5); 29 patients were severely FXI‐deficient (<20 IU dL−1). FXI was administered prophylactically before 43 surgical procedures, 10 invasive procedures, 8 vaginal deliveries, or as curative treatment for six bleeds. The efficacy was assessed as excellent/good in 63, moderate in two and undetermined in two treatments. Seven patients experienced seven adverse effects, including two rated as serious: one sudden massive pulmonary embolism with fatal outcome and one case of inhibitor to FXI. HEMOLEVEN is effective for bleeding prevention in FXI deficiency. However, considering the benefit/risk ratio observed in relation to dosage in this study; firstly, it should be used sparingly due to its potential prothrombotic effect; secondly, new prescription procedures should be defined to adapt the dosage, especially in patients with intrinsic and/or acquired risk factors for thrombosis.
Molecular characterization of epithelioid haemangioendotheliomas identifies novel WWTR1–CAMTA1 fusion variants
Authors: Patel Nimesh R , Salim Alaa A , Sayeed Hadi , Sarabia Stephen F , Hollingsworth Faith , Warren Mikako , Jakacky Jared , Tanas Munir , Oliveira Andre M , Rubin Brian P , Lazar Alexander J , López‐Terrada Dolores , Wang Wei‐Lien 
Published: March 2015

AimsEpithelioid haemangioendothelioma (EHE) is a malignant vascular neoplasm. Subsets have been characterized previously by translocations resulting in either WWTR1–CAMTA1 or YAP1–TFE3 fusion. We sought to develop molecular and immunohistochemical (IHC) assays to aid in the diagnosis and characterization of EHE.Methods and resultsFifty‐two formalin‐fixed, paraffin‐embedded (FFPE) cases diagnosed between 2002 and 2014 were retrieved from the pathology files of our institutions. Reverse transcription–polymerase chain reaction (RT–PCR) assays were optimized to detect WWTR1–CAMTA1 and YAP1–TFE3 fusion transcripts in FFPE tissue and transcription factor E3 (TFE3) protein accumulation was examined by immunohistochemistry (IHC). RNA was extracted from 33 adequate samples, with more recent cases providing a greater yield of high quality RNA. Fourteen of 18 informative cases were positive for WWTR1–CAMTA1 fusion transcripts, four of which showed higher‐grade cytological features termed by some as ‘malignant EHE’. Novel in‐frame fusion transcripts were identified in four cases by direct sequencing. IHC revealed variable nuclear TFE3 staining in six of 17 cases; three with patchy staining showed WWTR1–CAMTA1 fusion. One of 18 informative cases was positive for YAP1–TFE3 fusion and showed strong nuclear TFE3 staining by IHC.ConclusionsThis study confirms the high incidence of WWTR1–CAMTA1 and YAP1–TFE3 rearrangements in EHE and indicates that the staining pattern for TFE3 IHC is critical for specificity.
Cutaneous manifestations of immunoglobulin G4‐related disease: what dermatologists need to know
Authors: Lowe Garrett C. , Bogner Ryan R. , el‐Azhary Rokea A. , Gonzalez‐Santiago Tania M. , Kindle Scott A. , Lehman Julia S. , Gibson Lawrence E. 
Published: March 2015

AbstractIn this review, we summarize the recent literature and use case examples to reach diagnostic criteria for the diagnosis of immunoglobulin G4 (IgG4)‐related diseases that may be of relevance to the practicing dermatologist.
Genetic association of interleukin‐2, interleukin‐4, interleukin‐6, transforming growth factor‐β, tumour necrosis factor‐α and blood concentrations of calcineurin inhibitors in Turkish renal transplant patients
Authors: Seyhun Y. , Ciftci H. S. , Kekik C. , Karadeniz M. S. , Tefik T. , Nane I. , Turkmen A. , Oguz F. S. , Aydin F. 
Published: March 2015

SummaryCytokines are essential for the control of the immune response as most of the immunosuppressive drugs target cytokine production or their action. The calcineurin inhibitors (CNIs) cyclosporine (CsA) and tacrolimus are immunosuppressive drugs widely used after renal transplantation to prevent allograft rejection. They are characterized by large interindividual variability in their pharmacokinetics; therefore, monitoring their blood concentrations is important to predict their optimal dosage following transplantation. Calcineurin inhibitors inhibit the phosphatase activity of calcineurin, thereby suppressing the production of other cytokines such as transforming growth factor (TGF‐β), tumour necrosis factor‐α (TNF‐α), interleukin (IL)‐6, IL‐2, and IL‐4. The aim of this study was to investigate the relationship between polymorphisms of cytokines and blood concentrations of CNIs in renal transplant patients. The study included 53 CsA‐treated renal transplant patients and 37 tacrolimus‐treated renal transplant patients. Cytokine polymorphisms were analysed using polymerase chain reaction (PCR) sequence‐specific primers with the cytokine CTS‐PCR‐sequence‐specific primers Tray Kit; University of Heidelberg. Blood concentrations of CNIs were determined with Cloned Enzyme Donor Immunoassay (CEDIA) method. Patients with TC genotype of TGF‐β at codon 10 had lower CsA blood concentrations than the TT and CC genotypes (P = 0.005) at 1 month in CsA treatment group. The ratio of blood concentration/dose of CsA for patients with TGF‐β1‐codon 10 TC genotype was lower than for patients with TT, CC genotypes, and the dose given to these patients was higher in the first month (P = 0.046). The ratio of blood concentration/dose of CsA for patients with IL‐2‐330 GG genotype was higher than for patients with GT, TT genotypes, and the dose given to these patients was lower at first month and sixth months (P = 0.043, P = 0.035 respectively). The tacrolimus blood concentrations were significantly higher in patients with the genotype GG of IL‐2‐330 (P = 0.012) at the third month. Patients who had the TC genotype TGF‐β codon 10 had lower CsA blood concentrations and this group had higher acute rejection (P = 0.033). These results suggest that the genotyping for TGF‐β‐codon 10, IL‐2‐330 and IL‐6‐174 polymorphisms may help individualized immunosuppressive dosage regiments.
Evaluation of observational research reports published in Turkish nursing journals
Authors: Karaçam Z. , Şen E. , Yildirim B. 
Published: March 2015

AimThe aim of this literature‐based descriptive study was to examine the reporting of the observational research studies published in peer‐reviewed nursing journals in Turkey.MethodsEleven peer‐reviewed nursing journals printed on a regular basis in Turkey between 2007 and 2012 were selected. These journals were searched for observational research studies, and 502 studies were selected and examined by using the Strengthening the Reporting of Observational Studies in Epidemiology Statement.ResultsOf the 502 studies, 495 were cross‐sectional, 3 were cohort, and 4 were case controlled. Summary and introduction and aim sections were sufficient in most of the studies. The methods sections of the reports were mostly not reported: 64.3% of the reports did not indicate eligibility/inclusion criteria; sampling method, 67.0%; possible sources of bias, 99.2%; ways to reach sample size, 92.6%. In the results section, the number of individuals participating in each stage of the studies (44.0%) and in other analyses made (39.2%) was not reported. In the discussion section, a main comment about research findings was partly made (97.4%), and limitations of the studies and possible sources of bias were not written in 99.0% of the studies.ConclusionsThis study clearly revealed that the observational research studies published in nursing journals in Turkey did not fulfil the important criteria and needed to be improved.Implications for nursing and health policyInformation obtained from this study can contribute to improvement of the quality of reporting observational studies in nursing and thus using obtained findings in practice.
Low Loss, High NA Chalcogenide Glass Fibers for Broadband Mid‐Infrared Supercontinuum Generation
Authors: Zhang Bin , Guo Wei , Yu Yi , Zhai Chengcheng , Qi Sisheng , Yang Anping , Li Lei , Yang Zhiyong , Wang Rongping , Tang Dingyuan , Tao Guangming , Luther‐Davies Barry 
Published: March 2015

High‐purity Ge–As–Se and Ge–As–S chalcogenide glasses were prepared by modified physical and chemical purification techniques. Using the purified glasses, step‐index fibers with a small core (~5.5 μm) and large numerical aperture (~1.3) were fabricated. When a 13.5‐cm‐long fiber was pumped with 320 fs pulses at a repetition rate of 10.5 MHz at 4.1 μm, supercontinuum spanning from ~1.8 to ~9.8 μm with a dynamic range of ±10 dB and an average power of ~3 mW was generated.
A meta‐synthesis of factors influencing nursing home staff decisions to transfer residents to hospital
Authors: Laging Bridget , Ford Rosemary , Bauer Michael , Nay Rhonda 
Published: March 2015

AbstractAimTo report a meta‐synthesis of qualitative research studies exploring the role of nursing home staff in decisions to transfer residents to hospital.BackgroundNurses and nurse assistants provide the majority of care to residents living in nursing homes and may be the only health workers present when a resident deteriorates. To inform future strategies, it is vital to understand the role of nursing home staff in decisions to transfer to hospital.Design and review methodsA systematic review identified 17 studies to be included. The process of meta‐synthesis was undertaken using the Joanna Briggs Institute's guidelines.Data sourcesQualitative research papers published between January 1989–October 2012 were identified in key databases including Cinahl, Embase, Medline and PsycInfo.ResultsNursing home staff members play a key role in decision‐making at the time of a resident's deterioration. Multiple factors influence decisions to transfer to hospital including an unclear expectation of the nursing home role; limited staffing capacity; fear of working outside their scope of practice; poor access to multidisciplinary support and difficulties communicating with other decision‐makers.ConclusionsThere is a lack of consensus regarding the role of the nursing home when a resident's health deteriorates. Nursing home staff would benefit from a clear prescription of their expected minimum clinical skill set; a staffing capacity that allows for the increased requirements to manage residents on‐site, greater consistency in access to outside resources and further confidence and skills to optimize their role in resident advocacy.
Extended contact through cross‐group romantic relationships
Authors: Paterson Jennifer L. , Turner Rhiannon N. , Conner Mark T. 
Published: March 2015

AbstractCross‐group romantic relationships are an extremely intimate and often maligned form of intergroup contact. Yet, according to intergroup contact theory, these relationships have the potential to improve the intergroup attitudes of others via extended contact. This study combines the interpersonal and intergroup literatures to examine the outcomes associated with knowing a partner in a cross‐group romantic relationship. Results suggest that cross‐group romantic partners encounter greater disapproval toward their relationships than same‐group partners and, as a result, their relationships are perceived more negatively. Nevertheless, extended contact with cross‐group partners, controlling for participants' cross‐group friendships and romantic relationships, predicts more positive attitudes toward cross‐group dating and positive intergroup attitudes in general, mediated by perceived ingroup norms toward cross‐group relationships.
Rehabilitating civilian victims of war through psychosocial intervention in Sierra Leone
Authors: Mughal Ushna , Carrasco Diego , Brown Rupert , Ayers Susan 
Published: March 2015

AbstractThis research assessed an intervention (involving drug therapy and psychoeducational counseling) for war trauma in Sierra Leone. We examine the impact of the intervention on symptoms of post‐traumatic stress disorder (PTSD) and indicators of intergroup emotions and attitudes. Civilian war victims were drawn from a rehabilitation program (Intervention, N=50) or a waiting list Control group (N=50). The rehabilitation program combined general psychiatric treatment with additional life skills support. Those in the Intervention group had significantly lower PTSD symptoms and also scored lower on Intergroup Anxiety and Outgroup Blame, than those in Control. The intervention had an indirect effect on PTSD symptoms through Intergroup Anxiety. The reduction in PTSD in the intervention was greater for participants with a stronger identification with Sierra Leone.