bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multifunctional Hybrid Materials From Poly(3‐Hydroxybutyrate), TiO2 Nanoparticles, and Chitosan Oligomers by Combining Electrospinning/Electrospraying and Impregnation
Authors: Korina Elena , Stoilova Olya , Manolova Nevena , Rashkov Iliya 
Published: March 2013

AbstractSeveral types of fibrous material containing poly(3‐hydroxybutyrate) (PHB), nanosized TiO2‐anatase (nanoTiO2), and chitosan oligomers are prepared by combining the electrospinning, electrospraying, and impregnation techniques. Simultaneous electrospinning/electrospraying provides uniform distribution of electrosprayed nanoTiO2 along the PHB fibers and throughout the mat. Hybrid materials of different design manifest excellent photocatalytic activity, even after repeated use. They exhibit high bactericidal activity against Escherichia coli. In addition, the fibrous scaffolds are compatible with human mesenchymal stem cells and provide a favorable environment for their development. magnified image
A Novel Nanocage from the Cooperative Self‐Assembly of Coil–Rod–Coil Triblock Copolymers and Nanopartilces
Authors: Zhou Yang , Long Xin‐Ping , Zeng Qing‐Xuan , Zhang Chao‐Yang 
Published: March 2013

AbstractA Dissipative particle dynamics (DPD) simulations are performed to study the cooperative self‐assembly of coil–rod–coil triblock copolymers and nanoparticles in solution. The results show that, when the nanoparticle concentration exceeds a given value, the ternary systems can form a novel nanocage composed of two‐end coil‐caps and middle rod‐linkers. The novel nanocage is very similar to the real bird cage and the captured nanoparticles like the bird. It is the first nanocage from the self‐assembly of coil–rod–coil triblock copolymers. This may be used for the release of drugs and fertilizers, or as nanoreactors.
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Anthocyanins and proanthocyanidins from blueberry–blackberry fermented beverages inhibit markers of inflammation in macrophages and carbohydrate‐utilizing enzymes in vitro
Authors: Johnson Michelle H. , de Mejia Elvira Gonzalez , Fan Junfeng , Lila Mary Ann , Yousef Gad G. 
Published: March 2013

ScopeBerries are an excellent source of dietary flavonoids which have several health benefits.Methods and resultsWe evaluated well‐characterized anthocyanins (ANCs) and proanthocyanidins (PACs) from fermented blueberry–blackberry beverages. Wines were produced from highbush blueberries and blackberries grown in Illinois and blended to create ratios ranging from 100% blueberry to 100% blackberry. Total ANCs of the wine were strongly correlated to total phenolics (r = 0.99, p < 0.05) and to antioxidant capacity (r = 0.77, p < 0.05). ANC‐ and PAC‐enriched fractions were purified from each wine blend and a phenolic profile was generated. ANCs increased with more blackberries from 1114 to 1550 mg cyanidin‐3‐O‐glucoside (C3G) equivalents/L. Hydrolysable tannins were identified in the PAC‐enriched fraction. Both ANC‐ and PAC‐enriched fractions inhibited starch‐degrading enzyme α‐glucosidase and dipeptidyl peptidase‐IV activity. Computational docking demonstrated that delphinidin‐3‐arabinoside effectively inactivated dipeptidyl peptidase‐IV by binding with the lowest interaction energy (−3228 kcal/mol). ANC and PAC (100 μM C3G and epicatechin equivalents, respectively) from blueberry–blackberry blends reduced LPS‐induced inflammatory response in mouse macrophages via the nuclear factor kappa B‐mediated pathway.ConclusionANC‐ and PAC‐ (including hydrolysable tannins in blackberry) enriched fractions from blueberry and blackberry fermented beverages are beneficial sources of antioxidants, inhibitors of carbohydrate‐utilizing enzymes, and potential inhibitors of inflammation.
A hybrid variationally consistent homogenization approach based on Ritz's method
Authors: Bleier N. , Mosler J. 
Published: March 2013

SUMMARYMultiscale approaches based on homogenization theory provide a suitable framework to incorporate information associated with a small‐scale (microscale) problem into the considered large‐scale (macroscopic) problem. In this connection, the present paper proposes a novel computationally efficient hybrid homogenization method. Its backbone is a variationally consistent FE2 approach in which every aspect is governed by energy minimization. In particular, scale bridging is realized by the canonical principle of energy equivalence. As a direct implementation of the aforementioned variationally consistent FE2 approach is numerically extensive, an efficient approximation based on Ritz's method is advocated. By doing so, the material parameters defining an effective macroscopic material model capturing the underlying microstructure can be efficiently computed. Furthermore, the variational scale bridging principle provides some guidance to choose a suitable family of macroscopic material models. Comparisons between the results predicted by the novel hybrid homogenization method and full field finite element simulations show that the novel method is indeed very promising for multiscale analyses.Copyright © 2013 John Wiley & Sons, Ltd.
Agreement Between ICU Clinicians and Electrophysiology Cardiologists on the Decision to Initiate a QTc‐interval Prolonging Medication in Critically Ill Patients with Potential Risk Factors for Torsade de Pointes: A Comparative, Case‐Based Evaluation
Authors: Fongemie Justin M. , Al‐Qadheeb Nada S. , Estes N. A. Mark , Roberts Russel J. , Temtanakitpaisan Yutthapong , Ruthazer Robin , Devlin John W. 
Published: March 2013

Study ObjectivesTo measure concordance between different intensive care unit (ICU) clinicians and a consensus group of electrophysiology (EP) cardiologists for use of a common rate‐corrected QT interval (QTc)‐prolonging medication in cases containing different potential risk factor(s) for torsade de pointes (TdP).DesignProspective case‐based evaluation.SettingAcademic medical center with 320 beds.SubjectsMedical house staff (MDs) and ICU nurses (RNs) from one center and select critical care pharmacists (PHs).InterventionCompletion of a survey containing 10 hypothetical ICU cases in which patients had agitated delirium for which a psychiatrist recommended intravenous haloperidol 5 mg every 6 hours. Each case contained different potential risk factor(s) for TdP in specific combinations. A group of five EP cardiologists agreed that haloperidol use was safe in five cases and not safe in five cases.Measurements and Main ResultsFor each case, participants were asked to document whether they would administer haloperidol, to provide a rationale for their decision, and to state their level of confidence in that decision. Most clinicians (92 of 115 [80%]) invited to participate completed the cases. Among the five cases where EP cardiologists agreed that haloperidol was not safe, 29% of respondents felt that haloperidol was safe. Conversely, in the five cases where EP cardiologists felt haloperidol was safe, 21% of respondents believed that it was not safe. Overall respondent‐EP cardiologist agreement for haloperidol use across the 10 cases was moderate (κ = 0.51). MDs and PHs were in agreement with the EP cardiologists more than RNs (p=0.03). Interprofessional variability existed for the TdP risk factors each best identified. Clinician confidence correlated with EP cardiologist concordance for MDs (p=0.002) and PHs (p=0.0002), but not for RNs (p=0.69).ConclusionWhen evaluating use of a QTc interval‐prolonging medication, ICU clinicians often fail to identify the TdP risk factors that EP cardiologists feel should prevent its use. Clinician‐EP cardiologist concordance varies by the specific risk factor(s) for TdP and the ICU professional conducting the assessment.
Night‐to‐night consistency of at‐home nocturnal pulse oximetry testing for obstructive sleep apnea in children
Authors: Pavone Martino , Cutrera Renato , Verrillo Elisabetta , Salerno Teresa , Soldini Serena , Brouillette Robert T. 
Published: March 2013

AbstractRationaleAt‐home nocturnal pulse oximetry has a high positive predictive value (PPV) for polysomnographically‐diagnosed obstructive sleep apnea (OSA) but no studies have been published testing the night‐to‐night consistency of at‐home nocturnal pulse oximetry for the evaluation of suspected OSA in children. We therefore determined the night‐to‐night consistency of nocturnal pulse oximetry as a diagnostic test for OSA in children.MethodsWe prospectively studied 148 children (96 male) aged 4.9 ± 2.4 (1.2–11.8) years, referred for suspected OSA. To evaluate night‐to‐night consistency, we compared an oximetry analysis method, the McGill Oximetry Score (MOS), from two consecutive at‐home nocturnal pulse oximetry recordings.ResultsPulse oximetry metrics were similar on the two nights. The MOS on the two nights showed excellent night‐to‐night consistency when analyzed as positive for OSA versus inconclusive, 143/148 (Spearman's correlation coefficient = 0.90). A more detailed analysis using four categories (MOS 1, 2, 3, and 4) of OSA severity showed very good night‐to‐night agreement, 133/148 (Spearman's correlation coefficient = 0.91). Variability was increased in children younger than 4 years of age compared to older children.ConclusionsNight‐to‐night consistency of nocturnal pulse oximetry as a diagnostic test for OSA showed excellent agreement. Night‐to‐night consistency of pulse oximetry, as analyzed by the MOS, for diagnosis and severity evaluation further validates this abbreviated testing method for pediatric OSA. Polysomnography (PSG) is required to rule in or rule out OSA in children if a single night oximetry testing is inconclusive. Pediatr Pulmonol. 2013; 48:754–760. © 2012 Wiley Periodicals, Inc.
High pressure infrared and X‐ray Raman studies of aluminum nitride
Authors: Pravica Michael , Bhattacharya Neelanjan , Liu Yu , Robinson John , Au Wing‐Sing , Mizoguchi Teruyasu , Liu Zhenxian , Xiao Yuming 
Published: March 2013

AbstractWe performed the first reported static high pressure studies of the wide bandgap material aluminum nitride (AlN) using mid‐infrared (IR) and X‐ray Raman spectroscopy (XRS) up to 35 and 33 GPa, respectively, in a diamond anvil cell (DAC) at ambient temperature. For the first (IR) experiment, we employed a synchrotron IR source. Below the wurtzite (WZ) → rock salt (RS) phase transition, the IR spectra shift monotonically toward higher energy with pressure. Above this phase transition, the spectral multiplet stabilizes and then shifts toward lower energies suggesting a weakening of the bonding with pressure. To better examine the bonding changes we utilized the 16 ID‐D undulator beamline at the Advanced Photon Source (APS) for the second experiment. The spectrometer collected photons with ∼410 eV energy loss (nitrogen edge) with respect to incident beam energy near 10 keV. The sample commenced in the WZ phase and upon pressurization above ∼15 GPa, the sample converted into the high pressure RS form as evidenced by visual darkening of the sample and a marked change in the XRS pattern suggesting fundamental changes in intramolecular bonding. Upon pressure release, the sample remained in the high pressure RS phase and partially reverted to the low pressure WZ phase [confirmed with X‐ray diffraction (XRD)]. Theoretical calculations qualitatively agree with experimental observations.
Carbon Nanotube Photoelectronic and Photovoltaic Devices and their Applications in Infrared Detection
Authors: Yang Leijing , Wang Sheng , Zeng Qingsheng , Zhang Zhiyong , Peng Lian‐Mao 
Published: March 2013

AbstractSemiconducting carbon nanotubes (CNTs) are direct bandgap materials with outstanding electronic and optoelectronic properties and have been investigated for various electronic and optoelectronic device applications, such as light‐emitting diodes, photodetectors and photovoltaic cells. Here, a brief review of the various types of CNT diodes is presented, with a focus on one particular type of CNT diodes fabricated via a doping‐free process. Their application for constructing high‐performance optoelectronic and photovoltaic devices is also discussed, as well as the newly discovered photovoltage multiplication effect in CNTs and its application in improving the efficiency of CNT‐based infrared detector.
Nicotinamide Overcomes Pluripotency Deficits and Reprogramming Barriers
Authors: Son Myung Jin , Son Mi-Young , Seol Binna , Kim Min-Jeong , Yoo Chae Hwa , Han Myung-Kwan , Cho Yee Sook 
Published: March 2013

AbstractCrosstalk between intracellular signaling pathways has been extensively studied to understand the pluripotency of human pluripotent stem cells (hPSCs), including human embryonic stem cells and human induced pluripotent stem cells (hiPSCs); however, the contribution of NAD+-dependent pathways remains largely unknown. Here, we show that NAD+ depletion by FK866 (a potent inhibitor of NAD+ biosynthesis) was fatal in hPSCs, particularly when deriving pluripotent cells from somatic cells and maintaining pluripotency. NAD and its precursors (nicotinamide [NAM] and nicotinic acid) fully replenished the NAD+ depletion by FK866 in hPSCs. However, only NAM effectively enhanced the reprogramming efficiency and kinetics of hiPSC generation and was also significantly advantageous for the maintenance of undifferentiated hPSCs. Our molecular and functional studies reveal that NAM lowers the barriers to reprogramming by accelerating cell proliferation and protecting cells from apoptosis and senescence by alleviating oxidative stress, reactive oxygen species accumulation, and subsequent mitochondrial membrane potential collapse. We provide evidence that the positive effects of NAM (occurring at concentrations well above the physiological range) on pluripotency control are molecularly associated with the repression of p53, p21, and p16. Our findings establish that adequate intracellular NAD+ content is crucial for pluripotency; the distinct effects of NAM on pluripotency may be dependent not only on its metabolic advantage as a NAD+ precursor but also on the ability of NAM to enhance resistance to cellular stress.
Synthesis, Characterization, and X‐ray Crystal Structure of Macrocyclic Nickel/Iron/Sulfur Cluster Complexes
Authors: Li Yu‐Long , Xie Bin , Zou Li‐Ke , Lin Xiao , Zhu Sha‐Sha 
Published: March 2013

AbstractA series of macrocyclic Ni/Fe/S cluster complexes were synthesized and structurally characterized. The macrocyclic type of (diphosphine)Ni‐bridged double butterfly Fe/S complexes [μ‐SCH2CH2OCH2CH2S‐μ][(μ‐S=CS)Fe2(CO)6]2‐[Ni(diphosphine)] (1–3; diphosphine = dppe, dppv, dppb) were prepared by treatment of the dianion [{μ‐SCH2CH2OCH2CH2S‐μ}{(μ‐CO)Fe2(CO)6}2]2–, generated in situ from Fe3(CO)12, Et3N, and HSCH2CH2OCH2CH2SH with excess CS2 followed by treatment of the resulting dianion [{μ‐SCH2CH2OCH2CH2S‐μ}{(μ‐SC=S)Fe2(CO)6}2]2– with (diphosphine)NiCl2. The three complexes 1–3 were characterized by elemental analysis and IR, 1H NMR, and 31P NMR spectroscopy. In addition, the molecular structures of 2 and 3 were established by X‐ray crystallography.
Bromidovanadium(II, III, and IV) Complexes
Authors: Rehder Dieter , Nekola Henning , Behrens Axel , Cramer Stephen P. , Funk Tobias 
Published: March 2013

AbstractThe bromidovanadium complexes cis‐[VIIBr2(bith)] (1) [bith = 1,6‐bis(2‐benzimidazolyl)‐2,5‐dithiahexane], cis‐[VIIBr2(pth)] (2a) [pth = 1,6‐bis(2‐pyridyl)‐2,5‐dithiahexane], cis‐[VIIIBr2(pth)]Br (2b), trans‐[VIIBr2(tmeda)2] (3) (tmeda = tetramethylethylenediamine), fac‐[VIIIBr3(9S3)] (4) (9S3 = 1, 4, 7‐trithiacyclononane), mer‐[VIIIBr3(thf)3] (5) (thf = tetrahydrofurane), and trans‐[VIVOBr2(thf)2H2O] (6) were prepared and characterized by, inter alia, XRD (5, 6), K‐edge XAS (3, 4) or L‐edge XAS (2a, 2b). The complexes are also addressed in the context of the potential of halogenidovanadium compounds in catalytically conducted reactions, including biogenic processes.
Disruption of YPS1 and PEP4 genes reduces proteolytic degradation of secreted HSA/PTH in Pichia pastoris GS115
Authors: Wu Min , Shen Qi , Yang Yong , Zhang Sheng , Qu Wen , Chen Jing , Sun Hongying , Chen Shuqing 
Published: March 2013

Abstract
Human serum albumin (HSA) and human parathyroid hormone (1-34) [PTH (1-34)] fusion protein [HSA/PTH (1-34)] is a promising long-acting form of PTH (1-34) for osteoporosis treatment. Secretory expression of intact HSA/PTH (1-34) in Pichia pastoris GS115 was accompanied by two degradation fragments, with molecular weights around 66 kDa, in addition to the well-known ~45 kDa HSA-truncated fragment, resulting in a low yield of intact protein. In this study, two internal cleavage sites were identified in the PTH (1-34) portion of the fusion protein by Western Blot analysis. To minimize proteolytic cleavages, several protease genes including PEP4 (encoding proteinase A), PRB1 (proteinase B) and seven YPSs genes (yapsin family members) were knocked out respectively by disruption of the individual genes and the selective combinations. Reduced degradation was observed by single disruption of either PEP4 gene or YPS1 gene, and the lowest level of degradation was observed in a pep4△yps1△ double disruptant. After 72 h of induction, more than 80 % of the HSA/PTH (1-34) secreted by the pep4△yps1△ double disruptant remained intact, in comparison to only 30 % with the wild-type strain.
Benign Upper Extremity Tumors: Factors Associated with Operative Treatment
Authors: Sluijmer Heleen C. E. , Becker Stéphanie J. E , Ring David C. 
Published: March 2013

Background Tumors are common in the upper extremity and are mostly benign and inconsequential. The purpose of this study was to determine factors associated with operative treatment for suspected benign tumors of the upper extremity. Methods Treated by three different hand surgeons between July 2001 and July 2011, 1,593 tumors were identified using billing records. The measured variables were: sex, age, marital status, pain, neurovascular status, location of the tumor, bilateral involvement, preoperative diagnosis, prior surgeries in general, prior aesthetic surgery, prior tumor surgery in general, prior upper extremity tumors, prior upper extremity tumor surgery, prior surgery for same tumor, current or prior cancer, and number of visits before treatment. Variables associated with operative treatment were assessed in bivariate analysis and backwards elimination logistic regression analysis. Results Factors that significantly increased the probability of surgery were a higher number of visits before treatment, giant cell tumors, treated by surgeon A, lipomas, tumors located on the finger, and prior upper extremity tumors. Factors that significantly decreased the probability of surgery were treated by surgeon B and retinacular/tendon sheath ganglion cysts. Prior or current cancer was not significantly associated with operative treatment. Conclusions Tumor location, preoperative diagnosis, prior upper extremity tumor, and surgeon affect the likelihood of surgery for an upper extremity tumor. Level of evidence: Prognostic II
Active targeting of HER2-positive breast cancer cells by Herceptin-functionalized organically modified silica nanoparticles
Authors: Shirshahi Vahid , Shamsipour Fereshteh , Zarnani Amir Hassan , Verdi Javad , Saber Reza 
Published: March 2013

Abstract
Normal micelle microemulsion method was utilized for fabrication of organically modified silica (ORMOSIL) nanoparticles. The void and dye-doped nanoparticles were synthesized in nonpolar core of two different surfactants including Aerosol OT and Tween 80. The nanoparticles were characterized using transmission electron microscopy, dynamic light scattering, and zeta potential analysis. Our results revealed that the type of surfactant molecules has a dramatic impact on the size and size distribution range, surface charge, and surface functionalization of the nanoparticles. The particles fabricated using Tween 80 had very smaller size with narrow size distribution and very lower amount of zeta potential. For specific delivery of functionalized nanoparticles to breast cancer cell line SKBR3, overexpressing human epidermal growth factor receptor 2 (HER2), both dye-doped nanoparticles fabricated with Aerosol OT or Tween 80, was conjugated to Herceptin. In vitro studies using fluorescent microscopy demonstrated that the surfactant used for preparation of the nanoparticles can affect the uptake of the particles by cells. The dye-doped functionalized ORMOSIL nanoparticles prepared with Aerosol OT showed better efficiency in the process of active targeting of HER2 receptor. Herceptin-functionalized ORMOSIL nanoparticles can be used for differentiation of HER2-positive from HER2-negative breast cancer cells or specific delivery of therapeutic and diagnostic agents and also other nanoparticles such as magnetic nanoparticles and quantum dots to breast cancer cells.
On the analysis of the collaboration network of the Brazilian symposium on computer networks and distributed systems
Authors: Maia Guilherme , Vaz de Melo Pedro O. S. , Guidoni Daniel L. , Souza Fernanda S.H. , Silva Thiago H. , Almeida Jussara M. , Loureiro Antonio A. F. 
Published: March 2013

Abstract
The Brazilian symposium on computer networks and distributed systems (SBRC) reached its 30th edition as the paramount scientific event in the area of computer networks and distributed systems in Brazil. Faced with this opportune moment in the event’s history, we here study the collaboration network established among authors who have jointly published in the symposium. Towards that end, we collected bibliographic data from all 30 editions, and built the co-authorship network of the event. We then analyzed the network structural features and evolution throughout its history. Our results reveal the main kind of co-author relationship among authors, show the most prominent communities within SBRC, the regions of Brazil that attracts the most authors, the researchers with central roles in the network as well as the importance of inter-state collaborations. Finally, we align our results with historical facts that may have had a key impact on the symposium success.
Energy dissipation in atomic-scale friction
Authors: Hu Yuan-zhong , Ma Tian-bao , Wang Hui 
Published: March 2013

Abstract
The mechanisms of energy dissipation are discussed in this paper by reviewing the models and research in atomic-scale friction. The study is undertaken to answer a fundamental question in the study of friction: How is frictional work dissipated, particularly in cases where material damage and wear are not involved. The initiation of energy dissipation, the role of structural commensurability, and the estimation of the interfacial shear strength have been examined in detail by introducing the Tomlinson model, the Frenkel-Kontorova model, and the cobblestone model, respectively. The discussion is extended to energy dissipation progress described in terms of phononic and electronic damping. The contributions from other mechanisms of dissipation such as viscoelastic relaxation and material wear are also included. As an example, we analyzed a specific process of dissipation in multilayer graphene, on the basis of results of molecular dynamics (MD) simulations, which reveal a reversible part of energy that circulates between the system and the external driver. This leads us to emphasize that it is crucial in future studies to clearly define the coefficient of dissipation.