bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms for initiation of food allergy by skin pre‐disposed to atopic dermatitis
Authors: Gao Haoran , Kosins Allison E. , Cook‐Mills Joan M. 
Published: July 2024

SummaryFood allergy can be life‐threatening and often develops early in life. In infants and children, loss‐of‐function mutations in skin barrier genes associate with food allergy. In a mouse model with skin barrier mutations (Flakey Tail, FT+/− mice), topical epicutaneous sensitization to a food allergen peanut extract (PNE), an environmental allergen Alternaria alternata (Alt) and a detergent induce food allergy and then an oral PNE‐challenge induces anaphylaxis. Exposures to these allergens and detergents can occur for infants and children in a household setting. From the clinical and preclinical studies of neonates and children with skin barrier mutations, early oral exposure to allergenic foods before skin sensitization may induce tolerance to food allergens and thus protect against development of food allergy. In the FT+/− mice, oral food allergen prior to skin sensitization induce tolerance to food allergens. However, when the skin of FT+/− pups are exposed to a ubiquitous environmental allergen at the time of oral consumption of food allergens, this blocks the induction of tolerance to the food allergen and the mice can then be skin sensitized with the food allergen. The development of food allergy in neonatal FT+/− mice is mediated by altered skin responses to allergens with increases in skin expression of interleukin 33, oncostatin M and amphiregulin. The development of neonate food allergy is enhanced when born to an allergic mother, but it is inhibited by maternal supplementation with α‐tocopherol. Moreover, preclinical studies suggest that food allergen skin sensitization can occur before manifestation of clinical features of atopic dermatitis. Thus, these parameters may impact design of clinical studies for food allergy, when stratifying individuals by loss of skin barrier function or maternal atopy before offspring development of atopic dermatitis.
Municipal street‐sweeping area generation with route optimization
Authors: Parsons Tyler , Seo Jaho , Livesey Dan 
Published: July 2024

AbstractStreet sweeping is used in urban municipalities worldwide but requires a great deal of planning for large‐scale implementation. Municipalities typically make use of the macro‐ and microapproach by using operational areas in which routes are assigned, but creating operational areas without an understanding of the expected workload, number of routes, and the travel distance to and from the depot may lead to increased statistics. In this paper, a combination of heuristic approaches is used to assign street‐sweeping areas on the macroscale and generate street‐sweeping routes on the microscale. For the area assignment, a two‐stage cluster approach is proposed, making use of the weighted k‐means algorithm and differential evolution. For the route optimization, a three‐phase augment merge algorithm is used to create initial solutions, the u‐turns are minimized with a modified version of Hierholzer's algorithm and tabu search, and the remaining u‐turns are removed using a forward‐searching ant colony optimization. A case study in The City of Oshawa, Canada, was used to verify the proposed methodology, and all metrics were theoretically improved.
Association between volatile organic compounds exposure and periodontitis: A representative cross‐sectional study
Authors: Dong Haitao , Wang Xueting , Xiao Ning , Yang Xin , Zhang Xin , Niu Piye , Chen Tian 
Published: July 2024

AbstractAimPeriodontitis is one of the most common oral diseases and a major cause of tooth loss in adults. Environmental pollution is closely associated with the prevalence of periodontitis. However, few studies have focused on the association between volatile organic compounds (VOCs) and periodontitis. This cross‐sectional study aims to examine whether exposure to VOCs is associated with periodontitis, based on data from the National Health and Nutrition Examination Survey (NHANES, 2011–2014).Materials and MethodsWe analysed data on blood VOC levels, periodontitis and related covariates from 2772 participants of the NHANES. The association between the blood VOCs and periodontitis was analysed using weighted logistic regression analysis, the restricted cubic spline (RCS) model and the weighted quantile sum (WQS) regression model. Interaction tests and mediation analysis were also conducted.ResultsAfter adjusting for covariates, for each natural constant‐fold increase in 1,4‐dichlorobenzene, the odds of having periodontitis increased by 16% (odds ratio = 1.16; 95% confidence interval: 1.08–1.24, p < .001). WQS regression model indicated that 1,4‐dichlorobenzene contributed the most to the association between VOC co‐exposure and periodontitis. Mediation analysis further revealed that total bilirubin levels mediated the association between 1,4‐dichlorobenzene and the prevalence of periodontitis, accounting for 4.32%. In addition, the positive association between o‐xylene and periodontitis was more pronounced in the <65‐year‐old group.ConclusionsThis study has provided relatively little evidence to demonstrate a specific link between VOCs and periodontitis. Nonetheless, exposure to VOCs remains a non‐negligible public health concern, and further research is required to investigate the association and potential mechanisms of action between VOCs and periodontitis.
Maternal disapproval of friends in response to child conduct problems damages the peer status of pre‐ and early adolescents
Authors: Kaniušonytė Goda , Laursen Brett 
Published: July 2024

BackgroundHerein, we consider the hypothesis that mothers harm peer relations when they respond to child conduct problems by expressing disapproval of friends, which exacerbates the behavior problems they were presumably attempting to deter.MethodsA community sample of Lithuanian adolescents (292 boys and 270 girls, aged 9–14 years) completed surveys three times during an academic year. Classmate nominations indexed peer status (acceptance and rejection), self‐reports described perceived maternal disapproval of friends, and peer nominations and self‐reports separately gauged conduct problems.ResultsOver the course of a school year: (a) conduct problems were associated with subsequent increases in perceived maternal friend disapproval; (b) perceived maternal friend disapproval was associated with subsequent decreases in peer status; and (c) low peer status was associated with subsequent increases in conduct problems. Full longitudinal, random‐intercept cross‐lagged panel mediation models confirmed that mothers who disapproved of friends were sources of peer difficulties that culminated in conduct problems and intermediaries whose response to child conduct problems damaged peer relations. Findings were stronger for peer rejection than for peer acceptance, suggesting that peers actively dislike those with mothers who intervene in peer relationships.ConclusionsMaternal disapproval of friends in response to child conduct problems damages the child's standing among peers, which then exacerbates behavior problems. This consequential cascade underscores the need for parent education about the potential deleterious consequences of well‐intentioned interference in peer relations. Practitioners should be prepared to offer constructive, alternative solutions when youth present behavior problems.
Screening system for the detection of unknown or poorly controlled diabetes mellitus in a tertiary hospital: A retrospective study
Authors: Soriano Inés Borrego , Alcalá Beatriz Barquiel , Domínguez Óscar Moreno , Moreno Ana Laila Qasem , de Sevilla Elena García Pérez , de Villar Noemí González Pérez 
Published: July 2024

AbstractRationaleHospitalization may be a valuable chance for the detection of unknown and uncontrolled diabetes mellitus (DM). There is a screening tool at our hospital: in case of high inpatient plasma glucose level, an A1c value is added if no available from the last 3 months.Aims and ObjectivesOur objective was to analyse the population with A1c ≥ 9% detected through this system from 2021 to 2023.Materials and MethodsA retrospective study was performed. Three thousand five hundred seventy‐two patients were screened. We studied 243 patients with A1c ≥ 9%.ResultsFourty‐eight patients (19.8%) had unknown DM. The Endocrinology department was consulted in 39 cases (16%). In most of the cases (51%), there was not a mention in the discharge report, nor changes in the usual treatment (65.4%). Ninety patients (37%) improved A1c. Most of the ones that improved (58.9%) had a correct follow‐up, compared with those who did not (23.5%) (p < 0.01).ConclusionsMeasurement of A1c during hospitalization can help us to diagnose unknown or poorly controlled DM. Therapeutic inertia and delayed diagnosis are two problems associated to DM that are confirmed by our data.
Insights into the cooling rate and preservative effect of slurry ice on large yellow croaker (Pseudosciaena crocea) in terms of the fish/ice ratio, salinity, and the ice mass fraction
Authors: Lan Weiqing , Zhou Qi , Zhao Jiaxin , Zhao Yanan , Xie Jing 
Published: July 2024

AbstractThe cooling effect of slurry ice as cooling medium on large yellow croaker (Pseudosciaena crocea) was studied by considering different fish/ice ratio, salinity and initial ice mass fraction (40%, 60%, and 80%). Results obtained with optical microscope clarified that the ice particle size and cooling time of slurry ice were decreased at increasing salinity. Best precooling efficiency was obtained with specific values of fish/ice ratio 1:2, salinity 5.0%, and initial ice mass fraction 60%. Then, the effects of precooling time (0, 3, 12, and 24 h) in slurry ice on the quality of large yellow croaker stored at 4°C were investigated. The results showed that slurry ice precooling could significantly (p < 0.05) inhibit the microbial reproduction and retard the quality deterioration of large yellow croaker. Therefore, slurry ice can be a promising precooling method for the quality maintenance of marine fish.Practical applicationsLarge yellow croaker is extremely perishable due to its nutrient abundance. The spoilage process of fish is vitally influenced by the changes of internal environment and external environment after harvest. Timely precooling can prominently improve the shelf‐life of perishable foods. Slurry ice, a two‐phase system consisting of seawater (or artificial seawater) and spherical ice microcrystals, is regarded as an alternative precooling medium. Compared with conventional ice, slurry ice has faster cooling rate, little physical damage to soft tissue such as aquatic products and has better fluidity allows it to comprehensively cover the fish surface, thereby protecting fish from oxidation.
Groove pancreatitis: From enigma to future directions—A comprehensive review
Authors: Dahiya Dushyant S. , Shah Yash R. , Canakis Andrew , Parikh Charmy , Chandan Saurabh , Ali Hassam , Gangwani Manesh K. , Pinnam Bhanu S. M. , Singh Sahib , Sohail Amir H. , Patel Raj , Ramai Daryl , Al‐Haddad Mohammad , Baron Todd , Rastogi Amit 
Published: July 2024

AbstractGroove pancreatitis (GP) is a rare and clinically distinct form of chronic pancreatitis affecting the pancreaticoduodenal groove comprising the head of the pancreas, duodenum, and the common bile duct. It is more prevalent in individuals in their 4–5th decade of life and disproportionately affects men compared with women. Excessive alcohol consumption, tobacco smoking, pancreatic ductal stones, pancreatic divisum, annular pancreas, ectopic pancreas, duodenal wall thickening, and peptic ulcers are significant risk factors implicated in the development of GP. The usual presenting symptoms include severe abdominal pain, nausea, vomiting, diarrhea, weight loss, and jaundice. Establishing a diagnosis of GP is often challenging due to significant clinical and radiological overlap with numerous benign and malignant conditions affecting the same anatomical location. This can lead to a delay in initiation of treatment leading to increasing morbidity, mortality, and complication rates. Promising research in artificial intelligence (AI) has garnered immense interest in recent years. Due to its widespread application in diagnostic imaging with a high degree of sensitivity and specificity, AI has the potential of becoming a vital tool in differentiating GP from pancreatic malignancies, thereby preventing a missed or delayed diagnosis. In this article, we provide a comprehensive review of GP, covering the etiology, pathogenesis, clinical presentation, radiological and endoscopic evaluation, management strategies, and future directions. This article also aims to increase awareness about this lesser known and often‐misdiagnosed clinical entity amongst clinicians to ultimately improve patient outcomes.
Early clinical and quality impacts of the Age‐Friendly Health System in a Veterans Affairs skilled nursing facility
Authors: King Sarah E. , Ruopp Marcus D. , Mac Chi T. , O'Malley Kelly A. , Meyerson Jordana L. , Lefers Lindsay , Bean Jonathan F. , Driver Jane A. , Schwartz Andrea Wershof 
Published: July 2024

AbstractBackgroundSkilled nursing facilities (SNFs) are an ideal setting to implement the Age‐Friendly Health System (AFHS) approach, an initiative by the Institute for Healthcare Improvement (IHI) centered on the 4Ms: what matters, mobility, mentation, and medication. AFHS implementation has not been well studied in SNFs.MethodsA 112‐bed VA SNF implemented a facility‐wide AFHS initiative including the following: (1) participating in a national IHI Age‐Friendly Action Community; (2) establishing an AFHS workgroup centered on the 4Ms; (3) identifying meaningful clinical tools and frameworks for capturing each M; and (4) developing sustainment methods. Clinical (life‐sustaining treatment, falls, disruptive behaviors, and medication deprescribing) and quality outcomes (rehospitalization, emergency department utilization, and discharge to the community) in addition to patient satisfaction were compared pre‐ and post‐AFHS implementation (bed days of care [BDOC] 17413) to post‐implementation (BDOC 20880).ResultsClinical outcomes demonstrated improvements in the 4Ms, including: (1) what matters: 14% increase in life‐sustaining treatment documentation (82%–96%; p < 0.01); (2) mobility: reduction in fall rate by 34% (8.15 falls/1000 BDOC to 5.41; p < 0.01); (3) mentation: decrease in disruptive behavior reporting system (DBRS) by 62% (5.11 DBRS/1000 BDOC to 1.96; p = 0.04); (4) medications: 53% increase in average potentially inappropriate medications (PIMs) deprescribing (0.38–0.80 interventions/patient; p < 0.01). Quality outcomes improved including rehospitalization (25.6%–17.9%) and emergency department utilization (5.3%–2.8%) within 30 days of admission. Patient satisfaction scores improved from a mean of 77.2 (n = 31, scale 1–100) to 81.3 (n = 42).ConclusionsImplementation of the AFHS initiative in a SNF was associated with improved clinical and quality outcomes and patient satisfaction. We describe here a sustainable, interprofessional approach to implementing the AFHS in a SNF.
Obesity treatment in adolescents and adults in the era of personalized medicine
Authors: Sundbom Magnus , Järvholm Kajsa , Sjögren Lovisa , Nowicka Paulina , Lagerros Ylva Trolle 
Published: July 2024

AbstractIn this multi‐professional review, we will provide the in‐depth knowledge required to work in the expanding field of obesity treatment. The prevalence of obesity has doubled in adults and quadrupled in children over the last three decades. The most common treatment offered has been lifestyle treatment, which has a modest or little long‐term effect. Recently, several new treatment options—leading to improved weight loss—have become available. However, long‐term care is not only about weight loss but also aims to improve health and wellbeing overall. In the era of personalized medicine, we have an obligation to tailor the treatment in close dialogue with our patients. The main focus of this review is new pharmacological treatments and modern metabolic surgery, with practical guidance on what to consider when selecting and guiding the patients and what to include in the follow‐up care. Furthermore, we discuss common clinical challenges, such as patients with concurrent eating disorder or mental health problems, and treatment in the older adults. We also provide recommendations on how to deal with obesity in a non‐stigmatizing way to diminish weight stigma during treatment. Finally, we present six microcases—obesity treatment for persons with neuropsychiatric disorders and/or intellectual disability; obesity treatment in the nonresponsive patient who has “tried everything”; and hypoglycemia, abdominal pain, and weight regain after metabolic surgery—to highlight common problems in weight‐loss treatment and provide personalized treatment suggestions.
Association between obstructive sleep apnea and temporomandibular disorders: A meta‐analysis
Authors: Machado Cláudia Aparecida de Oliveira , de Resende Camila Maria Bastos Machado , Stuginski‐Barbosa Juliana , Porporatti André Luís , Carra Maria Clotilde , Michelloti Ambra , Boucher Yves , Simamoto Junior Paulo Cezar 
Published: July 2024

AbstractBackgroundObstructive sleep apnea (OSA) is a very common condition in patients with temporomandibular disorders (TMD). However, there is little evidence of a connection between them.ObjectiveThe aim of this systematic review and meta‐analysis is to assess the association between OSA and TMD in adult population.MethodsCase–control, cross‐sectional and cohort studies on the association between TMD and OSA were searched in the EMBASE, LILACS, LIVIVO, PubMed/MEDLINE, Scopus, Web of Science, Google Scholar, Open Grey and Pro Quest databases. TMD should be assessed using Research Diagnostic Criteria (RDC/TMD) or Diagnostic Criteria (DC/TMD) and OSA using polysomnography (PSG) and/or a validated questionnaire. The risk of bias was evaluated using the Joanna Briggs Institute Critical Assessment Checklists; and an association meta‐analysis was performed. The effect measure included the odds ratio (OR) in dichotomous variables and a 95% confidence interval (CI). Certainty of evidence was determined by analysing groups using the Grading of Recommendations Assessment, Development and Evaluation (GRADE).ResultsOut of the 1024 articles screened, 7 met the inclusion criteria for the qualitative synthesis, and 6 for quantitative analysis. All articles were classified at low risk of bias. A positive association with OSA was found in patients with TMD (OR = 2.61; 95% CI = 2.31, 2.95). A significant association was also found irrespective to the OSA diagnostic methods applied (for studies using PSG + validated questionnaires: OR = 2.74; 95% CI = 2.11, 3.57; for studies using validated questionnaires only: OR = 2.55; 95% CI = 2.22, 2.92). GRADE was moderate.ConclusionPatients with TMD presented a significant association with OSA regardless of the OSA diagnostic method (PSG and/or validated questionnaires). OSA screening should be part of the TMD examination routine. Furthermore, due to the different OSA assessment methods used and the small number of studies included, there is a need to include a larger number of studies using PSG to better elucidate this association.
Time spent away from bed is associated with oral hygiene and oral function: A cross‐sectional and multi‐institutional study
Authors: Yanagida Ryosuke , Tohara Haruka , Wakabayashi Hidetaka , Kinoshita Shoji , Sakai Kotomi , Isowa Tokiko , Nakagawa Kazuharu , Yamaguchi Kohei , Yoshimi Kanako , Momosaki Ryo 
Published: July 2024

AbstractBackgroundSpending time away from bed is important in older adults. Not doing so can lead to functional decline rapidly.ObjectiveTo investigate the association between oral function and time spent away from bed in older adults living in nursing homes.MethodsWe enrolled 748 adults aged ≥65 years across eight nursing homes between April 2022 and March 2023. ‘Problems with oral hygiene’ and ‘problems with oral function’ were the dependent variables in the multiple regression analyses to determine their association with time spent away from bed.ResultsWe selected 304 participants (76 men; mean age, 86.3 ± 7.5 years) and divided them into three groups: group S (< 4 h), group M (4 to < 6 h) and group L (≥ 6 h), with 28, 23 and 253 participants, respectively. Comparison of the characteristics between the groups demonstrated significant differences in the Barthel index (p < .001), time spent away from bed (p < .001), history of aspiration pneumonia (p < .001), confirmation of meals and food forms (p = .010), problems with oral hygiene (p = .014), and problems with oral function (p = .002). Based on multiple regression analyses, ‘problems with oral hygiene’ (p < .001) and ‘problems with oral function’ (p < .001) were significantly associated with time spent away from bed.ConclusionsThe time spent away from bed was significantly associated with both oral hygiene and function in older adults, suggesting the importance of extending the time that older adults spend away from bed.
Adolescents' perceptions of privacy violations by parents, siblings, and friends
Authors: Laird Robert D. , Hawk Skyler T. 
Published: July 2024

AbstractAdolescence is a life stage beset by a growing desire for privacy. This study evaluated adolescents' experiences across four types of potentially privacy‐invasive behaviors (PPIVBs) and within four different types of relationships. 158 adolescents (Mage = 16.9 years, SD = 1.0; 53.5% female) reported on the frequency of the PPIVBs, perceived control over the behaviors, secret/private information threatened by the behaviors, and feelings of privacy invasion produced by the behaviors. Privacy experiences were more similar across relationships than across types of behavior. Stronger feelings of privacy invasion were reported for PPIVBs involving electronics and information, for behaviors by family members, when behaviors occurred infrequently, when adolescents perceived greater control over whether the behaviors occurred, and when behaviors threated secret/private information.