bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between warfarin combined with serotonin-modulating antidepressants and increased case fatality in primary intracerebral hemorrhage: a population-based study
Authors: Löppönen Pekka , Tetri Sami , Juvela Seppo , Huhtakangas Juha , Saloheimo Pertti , Bode Michaela K. , Hillbom Matti 
Published: February 2014

Object
Patients receiving oral anticoagulants run a higher risk of cerebral hemorrhage with a poor outcome. Serotonin-modulating antidepressants (selective serotonin reuptake inhibitors [SSRIs], serotonin-norepinephrine reuptake inhibitors [SNRIs]) are frequently used in combination with warfarin, but it is unclear whether this combination of drugs influences outcome after primary intracerebral hemorrhage (PICH). The authors investigated case fatality in PICH among patients from a defined population who were receiving warfarin alone, with aspirin, or with serotonin-modulating antidepressants.

Methods
Nine hundred eighty-two subjects with PICH were derived from the population of Northern Ostrobothnia, Finland, for the years 1993–2008, and those with warfarin-associated PICH were eligible for analysis. Their hospital records were reviewed, and medication data were obtained from the national register of prescribed medicines. Kaplan-Meier survival curves were drawn to illustrate cumulative case fatality, and a Cox proportional-hazards analysis was performed to demonstrate predictors of death.

Results
Of the 176 patients eligible for analysis, 17 had been taking aspirin and 19 had been taking SSRI/SNRI together with warfarin. The 30-day case fatality rates were 50.7%, 58.8%, and 78.9%, respectively, for those taking warfarin alone, with aspirin, or with SSRI/SNRI (p = 0.033, warfarin plus SSRI/SNRI compared with warfarin alone). Warfarin combined with SSRI/SNRI was a significant independent predictor of case fatality (adjusted HR 2.10, 95% CI 1.13–3.92, p = 0.019).

Conclusions
Concurrent use of warfarin and a serotonin-modulating antidepressant, relative to warfarin alone, seemed to increase the case fatality rate for PICH. This finding should be taken into account if hematoma evacuation is planned.
Histological structure of filum terminale in human fetuses
Authors: Kural Cahit , Guresci Servet , Simsek Gulcin Guler , Arslan Erhan , Tehli Ozkan , Solmaz Ilker , Izci Yusuf 
Published: February 2014

Object
The structure of the filum terminale (FT) is important in the development of tethered cord syndrome (TCS) in children. Although many studies have been performed on the histological structure of the FT in adults, there has been no detailed investigation for those of fetuses. The aim of this study was to examine the histological structure of the FT in normal human fetuses and to compare the results with those of previous studies.

Methods
The histological examination of the FT was performed in 15 normal human fetuses; 11 of them were female and 4 were male. The gestational age of the fetuses ranged between 14 weeks and 35 weeks, and they weighed between 180 g and 1750 g. The FT of each fetus was cut and examined for adipose tissue, fibrous tissue, peripheral nerve, ganglion, ependymal cells, gliosis, elastic fibers, and collagen types (Types I and III).

Results
Adipose tissue was observed in 2 specimens (13%), whereas fibrous tissue was found in 8 specimens. Peripheral nerve was detected in 11 (73%), ganglion in 6, ependymal cells in 5, and glial tissue in 7 FT samples. Type III collagen was present in 12 specimens (80%) with different concentrations, whereas Type I collagen and elastic fibers were not detected.

Conclusions
The normal structure of the FT in fetuses is different from its structure in adults. The FT has no elasticity during intrauterine life because of the lack of elastic fibers. More detailed studies are needed to understand the histological basis of TCS in children.
E-Selectin S128R Gene Polymorphism in Gastric Cancer
Authors: Liarmakopoulos Emmanouil , Gazouli Maria , Aravantinos Gerasimos , Theodoropoulos George , Rizos Spyros , Vaiopoulou Anna , Kouraklis Gregory , Nikiteas Nikolaos 
Published: February 2014

Background E-selectin is an adhesion molecule expressed on activated endothelial cells. E-selectin plays an important role in the process of inflammation and is also involved in the mechanism of cancer metastasis regulating the adhesion of circulating cancer cells to the blood vessels. The aim of our study was to determine whether an association exists between its most common gene polymorphism, S128R, and gastric cancer (GC). Methods We performed a case-control study of 88 GC cases and 480 controls to analyze the association between E-selectin S128R gene polymorphism and GC susceptibility. The genotyping analysis was done by PCR-restriction fragment length polymorphism method. Results The E-selectin S128R C allele, CA and CC genotypes were over-represented among the GC cases. No statistically significant association was observed between E-selectin S128R polymorphisms and tumor characteristics. However, carrying the C allele was associated with poor survival. Conclusions The E-selectin S128R C allele may confer an increased susceptibility to gastric cancer development and correlate with a poor prognosis.
New challenges in the biomedical science: biobanking problems and solutions
Authors: Gudlevičienė Živilė , Chvatovič Genovefa 
Published: February 2014

Background. A huge progress has been recently made in the field of biomedical research and personalized medicine. Despite the advances of biobanking, significant limitations remain that are restricting the impact of researches. The major issues include the need to increase the quality and standardization of biospecimens and to maintain public trust. In general, it is named as harmonization of biobanking activities. The purpose of this article is to overview the current situation in biobanking issues and discuss about the possible solutions of these problems in Lithuania. The first steps in biobanking activities were made in the Institute of Oncology, Vilnius University (IOVU); several methods of DNA extraction from peripheral blood were tested and compared.
Materials and methods. During the experiment, four manual DNA extractions and one automated DNA purification method to determine the efficiency of each method in terms of the purity and yields of DNA extracted from blood samples were tested. DNA from patient’s blood remaining after a routine blood test was purified.
Results. Two of the four manual extraction methods produced good yields of DNA (from 57 to 126 µg/ml), the other two were of poor quality (from 8 to 47 µg/ml). In the same samples automatically isolated DNA concentrations ranged from 15 to 95 µg/ml.
Conclusions. The first steps for biobanking activities, SOPs creation and process harmonization were made in IOVU. Finally, after appreciation of the general situation the main threats in Lithuania could be proposed. The general working plan and strategy for biobanking in Lithuania, according to international rules and national needs, must be applied.
Methods of main bronchus stump closure and incidence of bronchopleural fistula after pneumonectomies for lung cancer (a retrospective single center review)
Authors: Cicėnas Saulius , Jackevičius Algirdas , Aškinis Renatas , Krasauskas Arnoldas , Šileika Nerijus , Samalavičius Narimantas Evaldas , Naujokaitis Pranas 
Published: February 2014

Background. Bronchopleural fistulas (BPFs) development after pneumo­nectomy remains a serious complication and is associated with high mortality rate. We evaluated incidence and risk factors, that influenced BPF rate after pneumonectomies for lung cancer patients treated at the Department of Thoracic Surgery and Oncology of the Institute of Oncology, Vilnius University, and compared different bronchial stump suturing techniques.
Methods. It is a retrospective study. We reviewed 580 lung cancer patients who underwent pneumonectomies from January 1990 to January 2009. The average patient’s age was 60.1 ± 7.9 years (range from 34 to 76). Patients according to postoperative staging: stage IIA – 30 patients, IIB – 80, IIIA – 320, IIIB – 96, IV – 54. The most common tumor histology was planocellular carcinoma – 301, adenocarcinoma – 108, small-cell carcinoma – 76.
Results. There were 327 (56.4%) right and 253 (43.6%) left pneumonectomies. Mediastinal lymph node dissection (LND) was performed to 387 (66.7%) and lymph node sampling (LNS) to 193 (33.3%) patients. The bronchial stump was covered in 285 (49.1%) patients. Bronchopleural fistula after pneumonectomy developed in 48 (8.3%) patients (bronchial dehiscence was confirmed by bronchoscopy), and 7 patients with BPF died (14.5%). BPF after right pneumonectomy occurred in 30 cases (9.5%) and after left pneumonectomy in 18 cases (7.1%), the difference was not statistically significant (p > 0.05). BPF after LND occurred in 38 cases (9.82%) and after LNS in 10 cases (5.18%), the dif­f erence was statistically significant (p
Le paradigme indiciaire dans La comédie humaine : le cas de la cognomologie
Authors: Smaniotto Ada 
Published: February 2014

En 1832, dans Le curé de Tours, Balzac augmente la série de ses sciences favorites : à la physiognomonie, à la phrénologie, mais aussi aux plus personnelles vestignomonie et élégantologie, s’ajoute la cognomologie. Si la conformation externe du visage ou crâne conditionne les instincts et facultés, la forme graphique et phonique du nom propre déterminerait le caractère de l’individu qu’il désigne. Le paradigme indiciaire mis en place par les sciences de Lavater et Gall s’étend donc dans La comédie humaine aux noms propres. La cognomologie, discipline désignée par un néologisme et précurseur de l’onomastique, participe de l’observation méthodique du réel et plus précisément des personnages. La mobilisation simultanée dans certains portraits d’indices physiques et onomastiques sert alors des desseins narratifs, esthétiques et épistémologiques. Le nom de certains personnages (Gobseck et Z. Marcas par exemple) ne doit cependant être réduit au statut de simple indice : talisman occulte, le nom peut, chez Balzac, donner accès au plus secret de l’individu. Le statut de la cognomologie balzacienne, ou plus généralement de la réflexion de l’auteur sur les noms, est donc à préciser. Légitimée par son lien avec la physiognomonie et la phrénologie, elle relève néanmoins de l’intuition démiurgique et place les noms propres au coeur d’une réflexion plus générale sur la création littéraire.
Separating body and Rayleigh waves with cross terms of the cross‐correlation tensor of ambient noise
Authors: Takagi Ryota , Nakahara Hisashi , Kono Toshio , Okada Tomomi 
Published: February 2014

AbstractWe develop a novel method to separate body and Rayleigh waves with the vertical‐radial (ZR) and radial‐vertical (RZ) components of the cross‐correlation tensor of ambient noise. Furthermore, analyzing ambient noise records observed at a seismic array, we validate the method. For the separation, we utilize the difference in polarizations between the rectilinear P and the elliptic Rayleigh waves. Assuming the two‐dimensional surface and three‐dimensional body waves are the superposition of random uncorrelated plane waves, we derive two fundamental characteristics of the ZR and RZ correlations. One is that between the ZR and RZ correlations, Rayleigh wave contributions have the opposite signs, and P waves have the same signs. The other is that for both ZR and RZ correlations, Rayleigh wave contributions are time symmetric, and P waves are time antisymmetric. Accordingly, we can separate P and Rayleigh waves by just taking the sum and difference between ZR and RZ correlations and by just taking the time‐symmetric and time‐antisymmetric components. This method can be performed (1) without any knowledge of velocity structure, (2) using only two stations with three‐component sensors on a ground surface, (3) even in the case of anisotropic wave incidence, and (4) with the quite simple procedure. We consider that the developed method can make better use of three‐component observations of ambient noise for evaluating the cross‐correlation tensor accurately, for improving deep velocity structure using both of extracted body and surface waves, and, more fundamentally, for understanding the composition of ambient noise.
Microphysical characteristics of MJO convection over the Indian Ocean during DYNAMO
Authors: Rowe Angela K. , Houze Robert A. 
Published: February 2014

AbstractThe microphysical characteristics of precipitating convection occurring in various stages of the Madden‐Julian Oscillation (MJO) over the Indian Ocean are determined from data obtained from the National Center for Atmospheric Research dual‐polarimetric Doppler S‐band radar, S‐PolKa, deployed as part of the Dynamics of the MJO (DYNAMO) field experiment. Active MJO events with increased rainfall occurred in October, November, and December 2011. During each of these active MJO phases, in addition to enhanced rainfall, convection became deeper and ice‐phase microphysics played a greater role. S‐PolKa consistently showed nonoriented small ice particles dominating the radar echoes at altitudes of 9–10 km, dry aggregates concentrated between 7 and 9 km, and wet aggregates and graupel near the melting level (~5 km). Graupel occurred mainly in actively convective towers, while the wet aggregates occurred almost exclusively in the stratiform regions of mesoscale convective systems (MCSs). During each of the three multiweek MJO active phases, the maximum rainfall occurred in short bursts lasting a few days. Each multiday rainy period began with deepening convective elements and a concurrent increase in occurrence of dry aggregates, which maximized just prior to organization into MCSs. The peak rainfall occurrence coincided with the maximum coverage of the radar domain by MCSs, reflecting large stratiform regions that exhibited the most frequent occurrence of wet aggregates. During the December active MJO phase, however, the MCSs were shallower and had a slightly lower tendency for wet aggregates in the stratiform regions and, therefore, generally weaker brightbands.
Microstructural Analysis of Electron Beam Cladded Surface Layers Using Co‐ and Fe‐Enriched Additives
Authors: Jung Anne , Zenker Rolf , Lerche Joachim , Lerche Kristina 
Published: February 2014

AbstractIn this report, an electron beam surface treatment technology is introduced by which applies a cladding layer of defined thickness is deposited on an austenitic steel (e.g., X6CrNiMoTi17‐12‐2) and a duplex steel (e.g., X2CrNiMoN22‐5‐3). The applied cladding alters the microstructure and, thus, the properties of the material's surface layer in such a way that a considerable improvement in mechanical properties is achieved. The Co‐ and Fe‐based additives used are deposited thermally to the base material in wire form by means of an electron beam (EB). The layer produced in this manner is free of cracks and pores, and is firmly bonded metallurgically to the substrate material. The cladding layers are evaluated with respect to their modification of the microstructure of the substrate material, and with respect to their effect on hardness. As a result of the high heating and cooling rates during EB application, an extremely fine, dendritic microstructure with homogenously distributed additive elements and low substrate material contents of between 19 and 37% is produced. An increase in hardness of between 2 and 3 times the hardness of the substrate material is thereby achieved.
Chronic granulomatous invasive fungal sinusitis: an evolving approach to management
Authors: Halderman Ashleigh , Shrestha Rabin , Sindwani Raj 
Published: February 2014

BackgroundChronic granulomatous invasive fungal sinusitis (CGIFS) is rare and a consensus on ideal management is lacking. We present an extensive case managed successfully with a conservative approach.MethodsCase report and literature review.ResultsThe patient presented with unilateral proptosis, papilledema, and headache. Imaging revealed an infiltrative process with extensive intracranial and intraorbital involvement. Biopsy showed fungal elements and granulomatous reaction consistent with CGIFS. The patient was managed with conservative surgery and long‐term oral voriconazole.ConclusionThis case supports a conservative surgical approach in some patients with extensive CGIFS. Oral voriconazole is effective and has significant advantages over more toxic agents administered intravenously.
Catalytic Asymmetric Tamura Cycloadditions
Authors: Manoni Francesco , Connon Stephen J. 
Published: February 2014

AbstractIn the presence of a novel, tert‐butyl‐substituted squaramide‐based catalyst, enolizable anhydrides react with alkylidene oxindoles to generate spirooxindole products of significant synthetic interest with excellent enantio‐ and diastereocontrol. The methodology is of wide scope and encompasses both homophthalic and glutaconic anhydride derivatives, which lead to structurally diverse products. Glutaconic acid‐derived anhydrides undergo a clean post‐cyclization decarboxylation process which is not a feature of reactions involving homophthalic acid‐derived anhydrides. The unusual influence of reaction temperature on diastereocontrol has been probed, with reactions occurring at 30 °C and −30 °C delivering products epimeric at one stereocenter only, in near optical purity.
Reactivity of Diruthenium and Dirhodium Analogues of Pentaborane(9): Agostic versus Boratrane Complexes
Authors: Anju R. S. , Roy Dipak Kumar , Mondal Bijan , Yuvaraj K. , Arivazhagan C. , Saha Koushik , Varghese Babu , Ghosh Sundargopal 
Published: February 2014

AbstractA series of novel Cp*‐based (Cp*=η5‐C5Me5) agostic, bis(σ‐borate), and boratrane complexes have been synthesized from diruthenium and dirhodium analogues of pentaborane(9). The synthesis and structural characterization of the first neutral ruthenadiborane(6) analogue are also reported. This new route offers a very efficient method for the isolation of bis(σ‐borate) and agostic complexes from diruthenapentaborane(9).
Bioinspired Green Composite Lotus Fibers
Authors: Wu Mengxi , Shuai Hua , Cheng Qunfeng , Jiang Lei 
Published: February 2014

AbstractOwing to the growing global environmental problems, demands for environmentally friendly, fully biodegradable sustainable composites have substantially increased across various industries. Inspired by the composite structure of cocoon silk, we fabricated a fully green composite fiber (GCF) that is based on the lotus fiber (LF) and a biodegradable polymer, namely poly(vinyl alcohol) (PVA). After the formation of cross‐linkages between the LF and PVA, the mechanical properties of this bioinspired GCF had substantially improved. In particular, the specific mechanical properties are superior to those of cocoon silk and other natural fibers. These findings suggest that LFs may be used as reinforcement materials for the fabrication of bulk green materials for various industries, such as the textile, medical, automobile, and aerospace industries.
Viable Photocatalysts under Solar‐Spectrum Irradiation: Nonplasmonic Metal Nanoparticles
Authors: Sarina Sarina , Zhu Huai‐Yong , Xiao Qi , Jaatinen Esa , Jia Jianfeng , Huang Yiming , Zheng Zhanfeng , Wu Haishun 
Published: February 2014

AbstractSupported nanoparticles (NPs) of nonplasmonic transition metals (Pd, Pt, Rh, and Ir) are widely used as thermally activated catalysts for the synthesis of important organic compounds, but little is known about their photocatalytic capabilities. We discovered that irradiation with light can significantly enhance the intrinsic catalytic performance of these metal NPs at ambient temperatures for several types of reactions. These metal NPs strongly absorb the light mainly through interband electronic transitions. The excited electrons interact with the reactant molecules on the particles to accelerate these reactions. The rate of the catalyzed reaction depends on the concentration and energy of the excited electrons, which can be increased by increasing the light intensity or by reducing the irradiation wavelength. The metal NPs can also effectively couple thermal and light energy sources to more efficiently drive chemical transformations.
Methylseleninic acid elevates REDD1 and inhibits prostate cancer cell growth despite AKT activation and mTOR dysregulation in hypoxia
Authors: Sinha Indu , Allen Joshua E. , Pinto John T. , Sinha Raghu 
Published: February 2014

AbstractMethylseleninic acid (MSeA) is a monomethylated selenium metabolite theoretically derived from subsequent β‐lyase or transamination reactions of dietary Se‐methylselenocysteine that has potent antitumor activity by inhibiting cell proliferation of several cancers. Our previous studies showed that MSeA promotes apoptosis in invasive prostate cancer cells in part by downregulating hypoxia‐inducible factor HIF‐1α. We have now extended these studies to evaluate the impact of MSeA on REDD1 (an mTOR inhibitor) in inducing cell death of invasive prostate cancer cells in hypoxia. In both PTEN+ and PTEN− prostate cancer cells we show that MSeA elevates REDD1 and phosphorylation of AKT along with p70S6K in hypoxia. Furthermore, REDD1 induction by MSeA is independent of AKT and the mTOR inhibition in prostate cancer cells causes partial resistance to MSeA‐induced growth reduction in hypoxia. Our data suggest that MSeA induces REDD1 and inhibits prostate cancer cell growth in hypoxia despite activation of AKT and dysregulation of mTOR.
Gas Analysis by In Situ Combustion in Heavy‐Oil Recovery Process: Experimental and Modeling Studies
Authors: Ahmadi Mohammad‐Ali , Masumi Mohammad , Kharrat Riaz , Mohammadi Amir H. 
Published: February 2014

AbstractEnormous efforts have been made to facilitate produced‐gas analyses by in situ combustion implication in heavy‐oil recovery processes. Robust intelligence‐based approaches such as artificial neural network (ANN) and hybrid methods were accomplished to monitor CO2/O2/CO. Implemented optimization approaches like particle swarm optimization (PSO) and hybrid approach focused on pinpointing accurate interconnection weights through the proposed ANN model. Solutions acquired from the developed approaches were compared with the pertinent experimental in situ combustion data samples. Implication of hybrid genetic algorithm and PSO in gas analysis estimation can lead to more reliable in situ combustion quality predictions, simulation design, and further plans of heavy‐oil recovery methods.