bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reduction of Cancer-Related Fatigue With Dexamethasone: A Double-Blind, Randomized, Placebo-Controlled Trial in Patients With Advanced Cancer
Authors: Yennurajalingam Sriram , Frisbee-Hume Susan , Palmer J. Lynn , Delgado-Guay Marvin O. , Bull Janet , Phan Alexandria T. , Tannir Nizar M. , Litton Jennifer Keating , Reddy Akhila , Hui David , Dalal Shalini , Massie Lisa , Reddy Suresh K. , Bruera Eduardo 
Published: July 2013

Purpose Cancer-related fatigue (CRF) is the most common symptom in patients with advanced cancer. The primary objective of this prospective, randomized, double-blind, placebo-controlled study was to compare the effect of dexamethasone and placebo on CRF. Patients and Methods Patients with advanced cancer with ≥ three CRF-related symptoms (ie, fatigue, pain, nausea, loss of appetite, depression, anxiety, or sleep disturbance) ≥ 4 of 10 on the Edmonton Symptom Assessment Scale (ESAS) were eligible. Patients were randomly assigned to either dexamethasone 4 mg or placebo orally twice per day for 14 days. The primary end point was change in the Functional Assessment of Chronic Illness–Fatigue (FACIT-F) subscale from baseline to day 15. Secondary outcomes included anorexia, anxiety, depression, and symptom distress scores. Results A total of 84 patients were evaluable (dexamethasone, 43; placebo, 41). Mean (± standard deviation) improvement in the FACIT-F subscale at day 15 was significantly higher in the dexamethasone than in the placebo group (9 [± 10.3] v 3.1 [± 9.59]; P = .008). The improvement in FACIT-F total quality-of-life scores was also significantly better for the dexamethasone group at day 15 (P = .03). The mean differences in the ESAS physical distress scores at day 15 were significantly better for the dexamethasone group (P = .013, respectively). No differences were observed for ESAS overall symptom distress (P = .22) or psychological distress score (P = .76). Frequency of adverse effects was not significantly different between groups (41 of 62 v 44 of 58; P = .14). Conclusion Dexamethasone is more effective than placebo in improving CRF and quality of life in patients with advanced cancer.
Bortezomib-Based Versus Nonbortezomib-Based Induction Treatment Before Autologous Stem-Cell Transplantation in Patients With Previously Untreated Multiple Myeloma: A Meta-Analysis of Phase III Randomized, Controlled Trials
Authors: Sonneveld Pieter , Goldschmidt Hartmut , Rosiñol Laura , Bladé Joan , Lahuerta Juan José , Cavo Michele , Tacchetti Paola , Zamagni Elena , Attal Michel , Lokhorst Henk M. , Desai Avinash , Cakana Andrew , Liu Kevin , van de Velde Helgi , Esseltine Dixie-Lee , Moreau Philippe 
Published: July 2013

Purpose To characterize efficacy and safety of bortezomib-based versus nonbortezomib-based induction regimens through an integrated analysis of data from phase III studies in transplantation-eligible patients with previously untreated myeloma. Patients and Methods Patient-level data from the IFM 2005-01 (bortezomib-dexamethasone v vincristine-doxorubicin-dexamethasone [VAD] induction), HOVON-65/GMMG-HD4 (bortezomib-doxorubicin-dexamethasone v VAD), and PETHEMA GEM05MENOS65 (bortezomib-thalidomide-dexamethasone v thalidomide-dexamethasone) studies were pooled in an integrated analysis of efficacy and safety. Study-level data from the GIMEMA MM-BO2005 study (bortezomib-thalidomide-dexamethasone v thalidomide-dexamethasone) supplemented the integrated patient-level analysis. Key efficacy end points were post-transplantation complete plus near-complete response (CR+nCR) rate and progression-free survival (PFS). Results Patient-level data for 1,572 patients (bortezomib-based induction, n = 787; nonbortezomib-based induction, n = 785) were included. Post-transplantation CR+nCR rate was significantly higher following bortezomib-based versus nonbortezomib-based induction (38% v 24%; odds ratio, 2.05; P < .001); the benefit remained similar (pooled odds ratio, 1.96) when GIMEMA MM-BO2005 data were included. Median PFS was 35.9 months versus 28.6 months with bortezomib-based versus nonbortezomib-based induction, respectively (hazard ratio, 0.75; P < .001); 3-year overall survival (OS) rates were 79.7% and 74.7%, respectively (hazard ratio for OS, 0.81; P = .0402). Median duration of induction treatment was 11 weeks in both treatment groups. Rates of peripheral neuropathy during induction were 34% versus 17% (grade ≥ 3, 6% v 1%). Overall, 3% and 4% of patients died during bortezomib-based and nonbortezomib-based induction, respectively. Conclusion Bortezomib-based induction results in significant improvements in response and PFS/OS compared with nonbortezomib-based induction and is generally well tolerated, with a higher rate of peripheral neuropathy but no apparent increase in risk of death during induction.
Identification and molecular characterization of the second Chlamydomonas gun4 mutant, gun4-II
Authors: Grovenstein Phillip B , Wilson Darryel A , Lankford Kathryn D , Gaston Kelsey A , Perera Surangi , Mitra Mautusi 
Published: July 2013

The green micro-algaChlamydomonasreinhardtiiis an elegant model organism to study oxygenic photosynthesis. Chlorophyll (Chl) and heme are major tetrapyrroles that play an essential role in photosynthesis and respiration. These tetrapyrroles are synthesized via a common branched pathway that involves mainly enzymes, encoded by nuclear genes. One of the enzymes in the pathway is Mg chelatase (MgChel). MgChel catalyzes insertion of Mg2+into protoporphyrin IX (PPIX, proto) to form Magnesium-protoporphyrin IX (MgPPIX, Mgproto), the first biosynthetic intermediate in the Chl branch. The GUN4 (genomes uncoupled 4) protein is not essential for the MgChel activity but has been shown to significantly stimulate its activity. We have isolated a light sensitive mutant,6F14,by random DNA insertional mutagenesis.6F14cannot tolerate light intensities higher than 90-100 μmol photons m-2s-1. It shows a light intensity dependent progressive photo-bleaching.6F14is incapable of photo-autotrophic growth under light intensity higher than 100 μmol photons m-2s-1. PCR based analyses show that in6F14the insertion of the plasmid outside theGUN4locus has resulted in a genetic rearrangement of theGUN4gene and possible deletions in the genomic region flanking theGUN4gene. Ourgun4mutant has a Chl content very similar to that in the wild type in the dark and is very sensitive to fluctuations in the light intensity in the environment unlike the earlier identifiedChlamydomonas gun4mutant. Complementation with a functional copy of theGUN4gene restored light tolerance, Chl biosynthesis and photo-autotrophic growth under high light intensities in6F14.6F14is the secondgun4mutant to be identified inC. reinhardtii. Additionally, we show that our twogun4complements over-express the GUN4 protein and show a higher Chl content per cell compared to that in the wild type strain.
Blogging on the ice: Connecting audiences with climate-change sciences
Authors: Thorsen Einar 
Published: July 2013

Abstract
Scientists working in Antarctica have recognized the need to counteract problems associated with mainstream media’s treatment of the climate-change crisis. For this reason, several of them have assumed the role of citizen journalists in order to report on the effects of global warming first-hand. More specifically, they have chosen to communicate directly with the general public through official or personal blogs. In so doing they are capitalizing on the way the Internet is changing science news and journalism. This article draws on an analysis of more than 50 Antarctic blogs published during the International Polar Year (2007–08), as well as data from e-interviews with a broad selection of bloggers, in order to examine how scientists ‘on the ice’ act as citizen journalists. The article explores the idea of citizen journalism as education and the extent to which the scientists achieve an unmediated form of communication through their blogging efforts. It concludes by suggesting this new form of citizen journalism, beyond raising people’s awareness of the climate-change crisis, also signals an important way in which mainstream environmental reporting can be reinvigorated.
Relating Rice Grain Quality to Conditions during Sun Drying
Authors: Meas Pyseth , Paterson Anthony Henry John , Cleland Donald J. , Bronlund John E. , Mawson John , Hardacre Allan , Rickman Joseph Frederick 
Published: July 2013

Abstract
Rice grain conditions within the sun-drying bed predicted by a mathematical model during drying were used to relate drying parameters to the head rice yield (HRY) which is the key rice quality metric. A number of parameters were derived to characterise the mechanisms of grain fissures and breakage postulated in the literature, and the model was used to estimate these parameters. These parameters were then regressed against the HRY experimental data to determine the contributing mechanisms. An increase in bed temperature, the maximum temperature at the top of the bed, the size of the moisture content gradients within a rice grain and the difference from the critical point for drying were all found to negatively affect HRY. By stirring the bed regularly and covering and shading the bed during the hottest parts of the day, HRY can be significantly increased leading to better returns to the farmer.
Thermal conductivity of flat-pressed wood plastic composites at different temperatures and filler content
Authors: Prisco Umberto 
Published: July 2013

AbstractThe thermal conductivity of wood flour (WF) filled high-density polyethylene composites (wood plastic composite, WPC) is investigated experimentally as a function of filler content and temperature. Samples are prepared by compression molding process of previously blended and extruded WPC pellets, up to 50% weight content of WF. The thermal conductivity is measured by the heat flow meter technique in a temperature range from -15°C to 80°C. Experimental results show that the WPC thermal conductivity decreases with temperature and WF content, with the last effect due to the increase in porosity with the filler content, as confirmed by density measurements. Using the thermal conductivity of bare WF, the thermal conductivity of the wood material in WPC is estimated. This value successfully predicts the upper and lower bounds of the WPC thermal conductivity by means of the parallel and series conduction model of a multiphase composite material.
Crystal structure of (Z)-N-(17-(1-(dimethylamino)ethyl)-10,13-dimethyl-4-oxo-4,5,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta-[a]phenanthren-3-yl)-3-methylbut-2-enimidic acid dichloromethane monosolvate, C29H45Cl2N2O2
Authors: He Kang , Zou Juan , Wang Jin Xi , Du Jiang 
Published: July 2013

Abstract C29H45Cl2N2O2, monoclinic, P21 (no. 4), a = 8.4429(4) Å, b = 19.6901(9) Å, c = 9.0259(4) Å, β = 100.700(2)°, V = 1474.4 Å3, Z = 2, Rgt(F) = 0.0492, wRref(F2) = 0.1437, T = 293 K.
Crystal structure of (Z)-2-amino-4-(2-amino-2-(4-bromophenylthio)-1-cyanovinyl)-6-bromo-4H-chromene-3-carbonitrile, C19H12Br2N4OS
Authors: Gan Haifeng , Liu Xeuwei , Guo Kai 
Published: July 2013

Abstract C19H12Br2N4OS, triclinic, P1̅ (no. 2), a = 9.536(2) Å, b = 9.977(2) Å, c = 10.160(2) Å, α = 84.16(3)°, β = 81.34(3)°, γ = 86.25(3)°, V = 949.4 Å3, Z = 2, Rgt(F) = 0.0680, wRref(F2) = 0.1198, T = 293 K.
Cross-section measurements for the formation of manganese-52 and its isolation with a non-hazardous eluent
Authors: Buchholz M. , Spahn I. , Scholten B. , Coenen H. H. 
Published: July 2013

Summary
With respect to the production of no-carrieradded 52Mn nuclear reactions on natural chromium were investigated. Cross sections of the reactions natCr(p, x)48V, 48,49,51Cr, 52g,mMn were determined in the proton energy range of 7.6 to 45MeV. Additionally, production yields of 52g,mMn and 51Cr were measured in the energy range from 8.2 to 16.9MeV and therefrom the calculated saturation thick target yields were obtained as (2.55±0.31), (6.96±0.57), and (1.53±0.15) GBq/μA, respectively. For in vivo applications like PET, low toxicity is critical and sufficient activity of a radiolabelled compound mandatory. Thus, additional purification steps after separation of radionuclides and target materials have to be avoided. However, no isolation procedure has been reported in the literature so far where radiomanganese is directly obtained in a nonhazardous solution. Therefore a new separation procedure was developed utilizing the cation-exchange resin DOWEX 50W×8 (H+-form). 52gMn was quantitatively isolated from “bulk” chromium after 3 to 4 h in non-hazardous 0.067M ammonium citrate solution. Up to 99% of 52gMn activity was harvested within 10 to 15 mL eluent solution with no measureable 51Cr impurities.
Untersuchungen von Preußisch Blau-modifizierten Elektroden zur H2O2-Bestimmung
Authors: Rabbow Thomas , Schneider Michael , Michaelis Alexander , Decker Manfred , Vonau Winfried , Konat-Stepowicz Joanna , Eichler Rüdiger 
Published: July 2013

Zusammenfassung
Zur empfindlichen quantitativen elektrochemischen Bestimmung von Wasserstoffperoxid wurden Graphitfasern erfolgreich mit Preußisch Blau (PB) modifiziert. Bei den Messungen an diesen Elektroden wurde ein linearer Zusammenhang zwischen der geflossenen Ladung und der zugegebenen nanomolaren Menge an H2O2 gefunden. Die PB-Abscheidung wurde zuvor an Gold-Dickschichtelektroden untersucht. Perspektivisch soll das System zur Messung von H2O2 in feuchter Raumluft und im Atemkondensat dienen.
Single Cable, Multichannel Measuring System for Heavy Load, High Impact Drop Tests
Authors: Bartholmai Matthias , Kammermeier Michael , Werner Klaus-Dieter , Wilk Tabea 
Published: July 2013

Abstract
Multichannel measuring systems are used to measure strains and accelerations during drop tests of containments for dangerous goods. Conventional systems require cabling of each sensor and co-falling of the cable harness, causing problems in the test preparation and execution. Promising results of a single cable measuring system, consisting of measuring modules with data bus connection and local data acquisition were presented in a previous study. This paper follows up with results from laboratory and full-scale testing of an further enhanced single cable system for the application in drop tests.
Assessing Functional Impairment in Siblings Living With Children With Disability
Authors: Goudie Anthony , Havercamp Susan , Jamieson Barry , Sahr Timothy 
Published: July 2013

OBJECTIVE:
The purpose of this study was to empirically test if siblings of children with disability had higher levels of parent-reported behavioral and emotional functional impairment compared with a peer group of siblings residing with only typically developing children.

METHODS:
This was a retrospective secondary analysis of data from the Medical Expenditure Panel Survey. We included only households with at least 2 children to ensure sibling relationships. Two groups of siblings were formed: 245 siblings resided in households with a child with disability and 6564 siblings resided in households with typically developing children. Parents responded to questions from the Columbia Impairment Scale to identify functional impairment in their children.

RESULTS:
On the basis of parent reports and after adjusting for sibling demographic characteristics and household background, siblings of children with disability were more likely than siblings residing with typically developing children to have problems with interpersonal relationships, psychopathological functioning, functioning at school, and use of leisure time (P &lt; .05). The percentage of siblings of children with disability classified with significant functional impairment was 16.0% at the first measurement period and 24.2% at the second (P &lt; .001). For siblings of typically developing children there was a smaller percentage increase from 9.5% to 10.3% (P &lt; .001).

CONCLUSIONS:
Functional impairment is a key indicator for the need of mental health services and, as such, early assessment and interventions to limit increasing severity and short- to long-term consequences need to be addressed. Health care professionals need to consider a family-based health care approach for families raising children with disability.
Intermittent Parathyroid Hormone Administration Improves Periodontal Healing in Rats
Authors: Vasconcelos Daniel Fernando Pereira , Marques Marcelo Rocha , Benatti Bruno Braga , Barros Silvana Pereira , Nociti Júnior Francisco Humberto , Novaes Pedro Duarte 
Published: July 2013

Background: Intermittent administration of parathyroid hormone (PTH) promotes new bone formation in patients with osteoporosis and bone fractures. It was shown previously that PTH also reduces periodontitis‐related bone loss. The aim of this study is to evaluate the effect of treatment with PTH on periodontal healing in rats.Methods: Fenestration defects were created at the buccal surface of the distal root of the mandibular first molars, and both periodontal ligament (PDL) and cementum were removed. Animals were then assigned to two groups (eight animals per group): group 1: control, placebo administration; and group 2: test, human PTH (hPTH) 1‐34 administration at a concentration of 40 μg/kg. For both groups, the animals were injected every 2 days, and the animals were sacrificed at 14 and 21 days after surgery. Specimens were harvested and processed for routine decalcified histologic sections. The following parameters were assessed: 1) remaining bone defect extension (RBDE); 2) newly formed bone density (NFBD); 3) total callus area (TCA); 4) osteoclast number (ON) in the callus region; and 5) newly formed dental cementum‐like tissue (NFC). Birefringence of root PDL reattachment was also evaluated.Results: Birefringence analysis showed root PDL reattachment for both groups 21 days after treatment. Intermittent hPTH 1‐34 administration decreased RBDE (P <0.01) and increased NFBD (P <0.01), TCA (P <0.01), area of NFC (P <0.01), and ON in the callus region (P <0.01).Conclusion: Within the limits of the present study, intermittent administration of hPTH 1‐34 led to an enhanced periodontal healing process compared with non‐treated animals.
Pseudoisotachis Pocsii Váňa, A New Genus and Species of Liverwort from the Subantarctic Marion Island
Authors: Váňa Jiří 
Published: July 2013

AbstractA new genus and new species of liverwort, Pseudoisotachis Váňa and Pseudoisotachis pocsii Váňa, is described from Marion Island, part of the Prince Edward Islands, a subantarctic archipelago situated in the Kerguelen Province of the southern Indian Ocean. Family placement of the new genus and species is uncertain due to absence of androecia, gynoecia and sporophytes; morphologically it is compared with some genera of Isotachidaceae and with the genus Orthocaulis of Anastrophyllaceae. The new species is described and illustrated.
Studies on Lophocoleaceae XXII. New Taxa and Combinations in New Zealand Heteroscyphus Schiffn
Authors: Engel John J. 
Published: July 2013

AbstractHeteroscyphus dentammophilus J. J. Engel & Merrill, Heteroscyphus parallelifolius J. J. Engel, and Heteroscyphus stoloniferus J. J. Engel are new species, and Lophocolea helmsiana var. subparallela E. A. Hodgs. is a new synonym of H. parallelifolius. Heteroscyphus circumdentatus var. clasmatocoleoides J. J. Engel & Merrill is a new variety, and Heteroscyphus menziesii (Mitt.) J. J. Engel is a new combination. All taxa are from New Zealand.
Brachymitrion Laciniatum (Splachnaceae) Rediscovered in South America
Authors: Cano María J. , Jiménez Juan A. 
Published: July 2013

Abstract Brachymitrion laciniatum (Spruce) A. K. Kop., previously only known from the type specimen collected by Richard Spruce in Ecuador in the mid-eighteenth century, has been rediscovered in South America and is reported for the first time in Peru. New data about its morphology are provided. The species is illustrated by the first time and its distribution mapped.
Finite difference scheme for the time-space fractional diffusion equations
Authors: Cao Jianxiong , Li Changpin 
Published: July 2013

Abstract
In this paper, we derive two novel finite difference schemes for two types of time-space fractional diffusion equations by adopting weighted and shifted Grünwald operator, which is used to approximate the Riemann-Liouville fractional derivative to the second order accuracy. The stability and convergence of the schemes are analyzed via mathematical induction. Moreover, the illustrative numerical examples are carried out to verify the accuracy and effectiveness of the schemes.
Optimal control strategies for coupled quantum dots
Authors: Räsänen Esa , Putaja Antti , Mardoukhi Yousof 
Published: July 2013

AbstractSemiconductor quantum dots are ideal candidates for quantum information applications in solid-state technology. However, advanced theoretical and experimental tools are required to coherently control, for example, the electronic charge in these systems. Here we demonstrate how quantum optimal control theory provides a powerful way to manipulate the electronic structure of coupled quantum dots with an extremely high fidelity. As alternative control fields we apply both laser pulses as well as electric gates, respectively. We focus on double and triple quantum dots containing a single electron or two electrons interacting via Coulomb repulsion. In the two-electron situation we also briefly demonstrate the challenges of timedependent density-functional theory within the adiabatic local-density approximation to produce comparable results with the numerically exact approach.
Deep Sequencing of the Murine Igh Repertoire Reveals Complex Regulation of Nonrandom V Gene Rearrangement Frequencies
Authors: Choi Nancy M. , Loguercio Salvatore , Verma-Gaur Jiyoti , Degner Stephanie C. , Torkamani Ali , Su Andrew I. , Oltz Eugene M. , Artyomov Maxim , Feeney Ann J. 
Published: July 2013

Abstract
A diverse Ab repertoire is formed through the rearrangement of V, D, and J segments at the IgH (Igh) loci. The C57BL/6 murine Igh locus has &gt;100 functional VH gene segments that can recombine to a rearranged DJH. Although the nonrandom usage of VH genes is well documented, it is not clear what elements determine recombination frequency. To answer this question, we conducted deep sequencing of 5′-RACE products of the Igh repertoire in pro-B cells, amplified in an unbiased manner. Chromatin immunoprecipitation–sequencing results for several histone modifications and RNA polymerase II binding, RNA-sequencing for sense and antisense noncoding germline transcripts, and proximity to CCCTC-binding factor (CTCF) and Rad21 sites were compared with the usage of individual V genes. Computational analyses assessed the relative importance of these various accessibility elements. These elements divide the Igh locus into four epigenetically and transcriptionally distinct domains, and our computational analyses reveal different regulatory mechanisms for each region. Proximal V genes are relatively devoid of active histone marks and noncoding RNA in general, but having a CTCF site near their recombination signal sequence is critical, suggesting that being positioned near the base of the chromatin loops is important for rearrangement. In contrast, distal V genes have higher levels of histone marks and noncoding RNA, which may compensate for their poorer recombination signal sequences and for being distant from CTCF sites. Thus, the Igh locus has evolved a complex system for the regulation of V(D)J rearrangement that is different for each of the four domains that comprise this locus.