bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nostalgic Sentiment And Cultural And Creative Industries In Regional Development: A Slovak Case Study
Authors: Borseková Kamila , Cole David , Petríková Katarína , Vaňová Anna 
Published: June 2015

Abstract
In Slovakia, there are three unique, historical mining towns, Banská Bystrica, Banská Štiavnica and Kremnica, that have been successfully turned into creative cultural centres. The historical and cultural values of those towns have stood the test of time and become a magnet for a new and creative class of people looking to escape the brutality of high modernity (modern urban centres) and find a source of inspiration based on historical nostalgic sentimentalism — the basis for a new creative and cultural industry for rural areas. The main objective of this paper is to analyse the cultural and creative industries of these three unique historical mining centres with an eye to replicating their knowledge in other communities in economic stress. The paper will first explore concepts relating to cultural and creative industries with an eye towards nostalgic sentimentalism that is an important antithesis to high modernity, and even post-modernity. The second part will analyse the cultural and creative industries of the three centres based on primary data collected from several research projects in this area. The final part will provide some recommendations for the facilitation of creative and cultural enterprises in regional redevelopment. It also contains policy recommendations for the self-government of the region for a more effective and rational exploitation of the existing potential hiding in plain view.
Factors influencing vitamin K antagonists therapy / Factori care influențează terapia cu antagoniști ai vitaminei K
Authors: Brudașcă Ioana 
Published: June 2015

AbstractVitamin K antagonists (VKAs) are widely used for the primary and secondary prevention of thromboembolism, their anticoagulant effect being monitored through INR. Achieving and maintaining a stable anticoagulation status is challenging, because of the narrow therapeutic range, and of the extremely variable individual response to therapy.Environmental factors such as age, gender, body mass, diet, herbal supplements, drugs, pre-existing pathology, as well as genetic factors can substantially influence the anticoagulant effect of VKAs. The main genetic factors that contribute to individual variability in response to VKAs are genetic polymorphisms in genes influencing VKAs’ metabolism (CYP2C9) and pharmacodynamic response (VKOR1) and account for about one third in the variation of warfarin and analogues dose requirement. Systematic genotyping of patients requiring warfarin therapy is still a matter of debate.Although novel oral anticoagulants (direct thrombin and factor Xa inhibitors) seem promising, VKAs are still frequently prescribed, therefore physicians should be aware of the various factors influencing VKAs’ effect, and educational programmes for doctors and patients should be conducted in that respect
Performance of an interferon-gamma release assay in the diagnosis of tuberculous meningitis in children / Performanţa testului bazat pe eliberarea interferonului gamma în diagnosticul meningitei tuberculoase la copil
Authors: Caliman-Sturdza Olga Adriana , Mihalache Doina , Luca Catalina Mihaela 
Published: June 2015

AbstractThe new immunodiagnostic tests based on the Mycobacterium tuberculosis specific antigen, early secretory antigenic target 6 (ESAT-6) and culture filtrate protein 10 (CFP-10), showed promising results in the diagnosis of tuberculosis infection. However, there are only few studies in the published literature on performance tests in cerebrospinal fluid. We investigated whether a rapid diagnosis of tuberculous meningitis (TBM) could be established by interferon-γ blood and cerebrospinal fluid (CSF) tests in children.We used the QuantiFERON-TB Gold in Tube test (QFT-IT) on blood and the QuantiFERON-TB Gold test (QFT-G) on the CSF of 63 subjects with TBM (including 25 case of definite TBM and 38 cases of probable TBM) and 62 controls.The CSF analyses indicated possible TBM in 63.4% of cases. The sensitivity of the CSF culture for Mycobacterium tuberculosis was only 39.6%. The sensitivity of the tuberculin skin test (TST) was 49.2% and the specificity was 88.6%. The estimated sensitivities of the QFT-G for the CSF and QFT-IT for the blood in culture confirmed TBM cases (gold standard) were 84% and 80%, respectively. The estimated specificities were 98.2% for the CSF and 87.9% for the blood. This study showed that the sensitivity of QFT for the CSF could be higher than TST and culture and slightly higher in CSF than in blood. The specificity of QFT-G for the CSF was higher those of the TST, but the specificity of QFT-IT is lower.QFT-G of the CSF is a useful diagnostic marker of tuberculosis that may improve the management of TBM, but the test results must be correlated with clinical, radiological and characteristics of CSF. New researches are needed to investigate the performance of QFT-G in the CSF compared with ELISPOT and PCR
Coronary Sinus Lactate as Marker of Myocardial Ischemia in Cardiac Surgery: Correlation with Morbidity and Mortality after Cardiac Surgery / Lactatul din sinusul coronarian - marker al ischemiei miocardice în chirurgia cardiacă: corelaţii cu morbiditatea şi mortalitatea postoperatorie
Authors: Raicea Victor , Kovacs Judit , Moraru Liviu , Suciu Horatiu 
Published: June 2015

AbstractIntroduction. Perioperative myocardial injuries are one of the most frequent causes of morbidity and mortality after cardiac surgery, the most common etiology being the poor myocardial protection during aortic crossclamp. During aortic crossclamp progressive accumulation of lactate and intracellular acidosis are well-known phenomena, and are associated with alteration of myocardial contractile function. Our objective was to study the coronary sinus lactate levels as a predictor of postoperative hemodynamic outcome in open-heart surgical patients.Material and methods. We performed a prospective clinical trial, including 142 adult patients with elective cardiac surgery. Anterograde cardioplegia was administered in 82 patients, retrograde cardioplegia in 60 (in 30 patients it was administrated intermittently and in 30 continuously). Blood was collected simultaneously from the aortic cardioplegic line (inflow) and from coronary sinus or the aortic root (outflow) before aortic crossclamp, after crossclamp at every 10 minutes and after crossclamp removal at 0 and 10 minutes. All patients were operated on cardiopulmonary bypass with cardiac arrest, using warm-blood cardioplegia for cardioprotection.Results. Lactate levels showed increasing values during aortic crossclamp, and a rapid decline after crossclamp removal. The incidence of low cardiac output was significantly higher in patients with lactate levels that exceeded 4 mmol/L. In patients who died in the postoperative period, lactate level was even higher (5 mmol/L), with only a modest recovery after crossclamp removal.Conclusion. Monitoring lactate level in coronary sinus blood is a reliable method and has a good prognostic value regarding postoperative morbidity and mortality in open heart surgery
From primer design to validation of results - is it possible by using free software only? / De la proiectarea primerilor la validarea rezultatelor - este posibil utilizând doar programe gratuite?
Authors: Man Adrian , Bănescu Claudia , Dobreanu Minodora , Fraefel Cornel 
Published: June 2015

AbstractSuccessful experiments in molecular biology require good knowledge about various methods and protocols. In molecular biology, nucleic acid manipulation is the essence, starting with the quality of extraction and ending with several analysis assays (PCR, RT-PCR, qPCR, PCR arrays, molecular cloning, etc). Though many of these are so called “standardized”, in practice there are many variables that can influence the outcome of the experiment. Due to the importance of optimal primer design in PCR assays, we will focus on primer designing and checking software, but we also present other useful free tools that can help researchers in the molecular biology field
Comparison of the predicted insulation of clothing in Toruń and Koniczynka in the years 1998–2012
Authors: Araźny Andrzej , Uscka-Kowalkowska Joanna , Kejna Marek 
Published: June 2015

Abstract:
Comparison of the predicted insulation of clothing in Toruń and Koniczynka in the years 1998–2012. This paper compares the predicted insulation of clothing (Iclp) in Toruń and Koniczynka, presented using a scale of evaluation of thermal environment proposed by B. Krawczyk (2000). The annual mean value of predicted insulation of clothing in urban areas of Toruń was equal to 1.0 clo, which was 0.1 less than in the agricultural area of Koniczynka. The influence of atmospheric circulation on the Iclp index was also analysed. The study used the circulation types as classified by Niedźwiedź (1981) in the Catalogue of atmospheric circulation for the Bydgoszcz-Toruń region (Przybylak and Maszewski 2009, 2013). The frequency of occurrence of individual circulation types was examined along with their influence on the predicted insulation of clothing in different seasons of the year and in an annual course. During the year, the highest mean value of Iclp (1.4 clo in Koniczynka) corresponded to cyclonic situations with northerly advection, whereas the lowest value (0.8 clo in Toruń and Koniczynka) was observed for the anticyclonic wedge.
Investigations of hydraulic operating conditions of air lift pump with three types of air-water mixers
Authors: Kalenik Marek 
Published: June 2015

Abstract:
Investigations of hydraulic operating conditions of air lift pump with three types of air-water mixers. The paper presents the analysis of results of the investigations concerning the influence of various constructive solutions of the air-water mixers on hydraulic operating conditions of the air lift pump. The scope of the investigations encompassed the determination of characteristics of delivery head and delivery rate for three types of air-water mixers applied in the constructed air lift pump. Using the obtained results, the efficiency of the three types of air-water mixers applied in this air lift pump was determined. The analysis was carried out and there was checked whether the improved analytical Stenning-Martin model can be used to design air lift pumps with the air-water mixers of these types. The highest capacity in the water transport was reached by the air lift pump with the 1st type air-water mixer, the lowest one – with the 3rd type air-water mixer. The water flow in the air lift pump increases along with the rise in the air flow. The lower are the hydraulic losses generated during flow of the air flux by the air-water mixer, the higher is the air lift pump capacity. Along with the rise in the water delivery head, the capacity of the air lift pump decreases. The highest efficiency is reached by the air lift pump with the 1st type air-water mixer, the lowest – with the 3st type air-water mixer. The efficiency of the air lift pump for the three investigated types of air-water mixers decreases along with the rise in air flow rate and water delivery head. The values of submergence ratio (h/L) of the delivery pipe, calculated with the use of the improved analytical Stenning-Martin model, coincide quite well with the values of h/L determined from the measurements.
Early 2015 Performance In Baltic Sea Ports: Forecasts Of Estonian Performance For Entire Year
Authors: Hilmola Olli-Pekka , Tolli Andres 
Published: June 2015

Abstract
Many changes have appeared in year 2015. In Europe economic malaise has continued since debt crisis started in year 2010, and although its effects on Northern Europe have started to diminish, new economic dark clouds have appeared through sanctions set by both European Union and Russia to each other during year 2014. Together with these, shipping sector has been under pressure due to strict sulphur regulation implemented from early 2015 onwards in the entire Baltic Sea Region. Due to these factors, sea ports at Baltic Sea have been under pressure during the first months of 2015, this particularly concerning container handling. Based on our regression model forecast, Estonia and Port of Tallinn shall have clearly declining container handling year ahead. However, overall handling at sea port is not so easy to forecast.
Users’ Perception And Reported Effects Of Long-term Access To In-Vehicle Traffic Information Services Mediated Through Nomadic Devices
Authors: Skoglund Tor , Wallgren Pontus , Karlsson MariAnne , Franzén Stig 
Published: June 2015

Abstract
ICT-mediated traffic information has been argued to contribute to a more sustainable transport system through affecting drivers. Nevertheless, long-term effects of travellers having access to nomadic in-vehicle systems for traveller information are not well known. This study presents the results from a multi-national large-scale field operational test (FOT). The results show that the users in general were positive to the tested systems and that there were several effects on their driving behaviour but in many cases the effects were limited. Moreover the effects varied between system types. Positive effects were related to comfort, as well as individual and system efficiency. One could also notice that perceived effects were not as high as the participants had expected, leading to some disappointment. Most of the times this was due to the tested systems functioning in a less than optimal way.
Formal And Informal Macro-Regional Transport Clusters As A Primary Step In The Design And Implementation Of Cluster-Based Strategies
Authors: Nežerenko Olga , Koppel Ott 
Published: June 2015

Abstract
The aim of the study is the identification of a formal macro-regional transport and logistics cluster and its development trends on a macro-regional level in 2007-2011 by means of the hierarchical cluster analysis. The central approach of the study is based on two concepts: 1) the concept of formal and informal macro-regions, and 2) the concept of clustering which is based on the similarities shared by the countries of a macro-region and tightly related to the concept of macro-region. The authors seek to answer the question whether the formation of a formal transport cluster could provide the BSR a stable competitive position in the global transportation and logistics market.
Employment Of IGBT-Transistors For Bipolar Impulsed Micro-Arc Oxidation
Authors: Krainyukov Alexander , Kutev Valery 
Published: June 2015

Abstract
The paper is devoted to the use of insulated gate bipolar transistors (IGBT) for the micro-arc oxidation (MAO) process. The technical requirements to the current switches of power supplies for the pulsed bipolar MAO technology have been developed. The research installation for investigating the IGBT commutation processes during the pulse anode-cathode oxidation has been constructed. The experiments have been performed with its help in order to estimate the possibility of using half-bridge IGBT-modules with different drivers. The research results of the commutation processes investigation for different IGBT half- bridge modules are presented.
Reversible Inactivation of the Bed Nucleus of the Stria Terminalis Prevents Reinstatement But Not Renewal of Extinguished Fear
Authors: Goode Travis D. , Kim Janice J. , Maren Stephen 
Published: June 2015

AbstractThe extinction of conditioned fear is labile. For example, fear to an extinguished conditioned stimulus (CS) returns after presentation of an aversive stimulus (“reinstatement”) or a change in context (“renewal”). Substantial research implicates the bed nucleus of the stria terminalis (BNST) in the stress-induced relapse of extinguished behaviors, such as in instrumental drug seeking, but its role in the relapse of extinguished fear responses is not clear. Here, we explored the role of the BNST in both the reinstatement and renewal of fear, two forms of relapse that are differentially triggered by stress. In Experiment 1, rats received pairings of an auditory CS and footshock unconditioned stimulus (US) followed by an extinction procedure. After extinction, rats received an unsignaled US to reinstate fear to the extinguished CS. Twenty-four hours later, they were infused with either muscimol or vehicle into the BNST immediately prior to a CS retrieval test. In Experiment 2, rats were conditioned and extinguished in two distinct contexts. Twenty-four hours after extinction, the rats were infused with muscimol, NBQX, or vehicle immediately prior to a CS retrieval test in either the extinction context or a different (but familiar) context. In both experiments, freezing behavior served as the index of conditioned fear. The results revealed that BNST inactivation prevented reinstatement (Experiment 1), but not renewal (Experiment 2), of conditioned freezing to the extinguished CS. Hence, the BNST is critical for the reinstatement of extinguished fear in an aversive context, but not for the contextual retrieval processes that mediate fear renewal.
Effects of Exercise on Progranulin Levels and Gliosis in Progranulin-Insufficient Mice
Authors: Arrant Andrew E. , Patel Aashka R. , Roberson Erik D. 
Published: June 2015

AbstractLoss-of-function mutations in progranulin (GRN) are one of the most common genetic causes of frontotemporal dementia (FTD), a progressive, fatal neurodegenerative disorder with no available disease-modifying treatments. Through haploinsufficiency, these mutations reduce levels of progranulin, a protein that has neurotrophic and anti-inflammatory effects. Increasing progranulin expression from the intact allele is therefore a potential approach for treating individuals withGRNmutations. Based on the well-known effects of physical exercise on other neurotrophic factors, we hypothesized that exercise might increase brain progranulin levels. We tested this hypothesis in progranulin heterozygous (Grn+/−) mice, which model progranulin haploinsufficiency. We housed wild-type and progranulin-insufficient mice in standard cages or cages with exercise wheels for 4 or 7.5 weeks, and then measured brain and plasma progranulin levels. Although exercise modestly increased progranulin in very young (2-month-old) wild-type mice, this effect was limited to the hippocampus. Exercise did not increase brain progranulin mRNA or protein in multiple regions, nor did it increase plasma progranulin, in 4- to 8-month-old wild-type orGrn+/−mice, across multiple experiments and under conditions that increased hippocampal BDNF and neurogenesis.Grn−/−mice were included in the study to test for progranulin-independent benefits of exercise on gliosis. Exercise attenuated cortical microgliosis in 8-month-oldGrn−/−mice, consistent with a progranulin-independent, anti-inflammatory effect of exercise. These results suggest that exercise may have some modest, nonspecific benefits for FTD patients with progranulin mutations, but do not support exercise as a strategy to raise progranulin levels.
Pendekatan Ekoregion Dalam Sistem Hukum Pengelolaan Sumber Daya Air Sungai di Era Otonomi Daerah
Authors: Triana Nita 
Published: June 2015

Hak atas lingkungan yang baik dan sehat dijamin oleh Pancasila dan UUD 1945 yang berimplikasi terhadap perlunya kebijakan, rencana dan/atau program mengenai hak atas lingkungan tersebut diatur dalam perundang-undangan, baik di tingkat nasional maupun daerah. Dalam konteks otonomi daerah hak atas lingkungan tersebut termasuk dalam kelompok bidang urusan wajib pemerintahan. Tulisan ini bertujuan untuk menganalisis dampak pengaturan hak atas lingkungan hidup dalam bidang sumber daya air. Hasil penelitian ini menunjukkan bahwa dampak pengaturan hak atas lingkungan hidup dalam sistem hukum pengelolaan sumber daya air sungai tidak terintegrasi dengan daerah lain, sehingga kebijakan pemerintah daerah lebih ditujukan untuk peningkatan pendapatan daerah masing-masing. Kondisi ini mengakibatkan terjadinya perusakan sumber daya air sungai di bagian hulu dan hilir dan tidak optimalnya pemanfaatan air sungai. Berdasarkan hal tersebut dibutuhkan sistem hukum pengelolaan sumber daya air dengan pendekatan ekoregion, dimana batas darat dan perairan tidak ditentukan oleh batas secara politik, akan tetapi oleh batas geografis dari komunitas manusia dan sistem lingkungan.<br /><br /><br /><em>The right to a good and healthy environment is guaranteed by Pancasila and the 1945 Constitution which has implications on the need for policies, plans and / or programs on environmental rights are set out in legislation, both at national and local levels. In the context of regional autonomy, rights to the environment including the obligatory group of government issues. This paper aims to analyze the impact of regulation on environmental rights in the field of water resources. The results of this study indicate that the impact of regulation on environmental rights in the legal system of management of water resources of the river is not integrated with other areas, so that local policy is intended to increase local revenues respectively. These conditions resulted in the destruction of the water resources of the river upstream and downstream and is not optimal utilization of river water. Under the terms of the legal system needs water resources management with ecoregion approach, where land and water boundaries are not defined by political boundaries, but by the geographical boundaries of the human community and environmental systems.</em><br /><br />