bluuebunny/crossref_metadata_2025_split huggingface dataset:
Updated therapeutic options for human brucellosis: A systematic review and network meta-analysis of randomized controlled trials
Authors: Huang Shanjun , Xu Jiaying , Wang Hao , Li Zhuo , Song Ruifang , Zhang Yiting , Lu Menghan , Han Xin , Ma Tian , Wang Yingtong , Hao Jiaxin , Song Shanshan , Zhen Qing , Shui Tiejun 
Published: August 2024

Background
In clinical practice guidelines, there is no consensus about the medications that should be initially offered to patients with brucellosis. To provide informative evidence, we compared and ranked brucellosis medications based on their efficacy and safety.

Methods
For this systematic review and network meta-analysis, we searched 4 English databases and 3 Chinese databases, from the date of database inception to December 13, 2023. We included randomized controlled trials (RCTs) involving children and adolescents with brucellosis, comparing different antibiotic regimens. We excluded studies explicitly targeting patients with spondylitis brucellosis, endocarditis brucellosis, and neuro-brucellosis. The primary outcomes were overall failure (efficacy) and side effects (safety). Secondary outcomes were relapse and therapeutic failure. Pairwise meta-analysis was first examined. Data were analyzed using random effects network meta-analysis, with subgroup and sensitivity analyses performed. The Confidence in Network Meta-Analysis (CINeMA) framework was used to assess the certainty of evidence. The protocol was preregistered in PROSPERO (CRD42023491331).

Results
Of the 11,747 records identified through the database search, 43 RCTs were included in the network meta-analysis. Compared with standard therapy (Doxycycline + Rifampicin), Rifampicin + Tetracyclines (RR 4.96; 95% CI 1.47 to 16.70; very low certainty of evidence), Doxycycline + TMP/SMX (RR 0.18; 95% CI 0.06 to 0.52; low certainty of evidence), Doxycycline + Quinolones (RR 0.27; 95% CI 0.11 to 0.71; low certainty of evidence), Streptomycin + Tetracyclines (RR 0.04; 95% CI 0.01 to 0.16; low certainty of evidence), and Single (RR 0.05; 95% CI 0.02 to 0.16; moderate certainty of evidence) were less efficacious. Doxycycline + Gentamicin ranked the best in efficacy (SUCRA values: 0.94), the second is Triple (SUCRA values: 0.87), and the third is Doxycycline + Streptomycin (SUCRA values: 0.78).

Conclusions
Brucellosis medications differ in efficacy and safety. Doxycycline + Gentamicin, Triple, and Doxycycline + Streptomycin have superior efficacy and safety. Treatment of brucellosis should strike a balance between efficacy, safety, and cost.
Person-centered maternity care and associated factors among women who give birth at public hospitals in South Gondar zone, North West Ethiopia, 2023
Authors: Dagnaw Gizachew Worku , Bizuneh Mekonen Melkie , Kassie Meseret Birhan 
Published: August 2024

Background
Person-centered maternity care (PCMC) is the process of maternity care that is responsive to and respectful of each woman’s choices, values, and needs. It reflects the quality of maternal health services. The provision of PCMC is influenced by the maternal sociodemographic and obstetric-related variables However, there is little information about person-centered maternity care in Ethiopia; particularly, communication & autonomy, and supportive care are not well investigated. Therefore, the purpose of this study was to assess the proportion of person-centered maternity care and associated factors among women who give birth at the public hospital, in North West, Ethiopia, 2023.

Methods
A facility-based cross-sectional study was conducted among 763 mothers who give birth at public hospitals in the South Gondar zone. The study participants were selected using a systematic random sampling technique. Data were collected through exit interviews using a structured pretested Amharic version questionnaire. EPI- Data version 4.6 was used for data entry and SPSS Version 25 for analysis. Bivariable & multivariable linear regression analysis was computed. Predictor variables were identified by using unstandardized β and a 95% confidence interval. A variable that has a p-value < 0.05 was considered statistically significant.

Results
The mean person-centered maternity care was 42.33 out of 90. Mothers living in rural areas (β = -1.43, 95% CI: -2.76,-0.11), 3–4 providers present during labor and delivery (β = -1.58, 95% CI:-3.67,-0.27), had no history of facility delivery (β = -2.28,95% CI:-4.43,-0.13), two days length of stay at hospitals (β = 1.69,95% CI:0.40,2.48), and highest wealth (β = 1.05,95% CI:0.42,1.41) were factors significantly associated with person-centered maternity care (PCMC).

Conclusion
The mean score of PCMC was low in the study area compared to studies done in low- and middle-income countries. Highest wealth, 3–4 health providers present during labor and delivery, had no history of facility delivery, and had two-day lengths of stay at hospitals were predictors for PCMC. Therefore, strengthening facility delivery and promoting hospital stays for more than a day as a part of first postnatal care is paramount for increasing PCMC.
Analysis of issues related to nursing law: Examination of news articles using topic modeling
Authors: Lee JooHyun , Chang Hyoung Eun , Cho Jaehyuk , Yoo Seohyun , Hyeon Joonseo 
Published: August 2024

Purpose
The objective of this study was to analyze proposed Korean nursing legislation as depicted in newspaper articles, to highlight issues related to the legislative process for this potential law, and to better understand social awareness regarding this matter.

Methods
The study focused on articles from 11 leading newspapers in Korea, published between February 2020 and August 2023, that pertained to nursing legislation. The articles were retrieved from the BigKinds database. Following text preprocessing, analytical methods including term frequency-inverse document frequency were employed, along with latent Dirichlet allocation (LDA), for word and topic modeling analysis. Additionally, LDA was applied across time periods to examine temporal changes in topics.

Results
Following preprocessing, a total of 7,967 words were extracted from the 991 articles selected for analysis. The primary themes identified in newspaper articles concerning the nursing legislation were organized into three main topics: 1) the necessity and impact of enactment of the nursing law, 2) the political context surrounding enactment of the law, and 3) the conflicts between and actions of healthcare organizations related to enactment of the law.

Conclusions
The findings confirmed that media coverage regarding the proposed nursing legislation primarily concentrated on the political and social conflicts associated with the law’s passage, rather than its necessity and substance. More compelling evidence must be presented concerning the influence of the nursing workforce and the work environment of nurses on patient safety and health outcomes. Additionally, strategies should be devised to improve public comprehension of the nursing law’s provisions.
Association between post-stroke depression and functional outcomes: A systematic review
Authors: Butsing Nipaporn , Zauszniewski Jaclene A. , Ruksakulpiwat Suebsarn , Griffin Mary T. Quinn , Niyomyart Atsadaporn 
Published: August 2024

Background
Post-stroke depression (PSD) is a frequent problem in stroke patients, affecting their rehabilitation process and functional outcomes. Several studies have investigated the relationship between PSD and functional outcomes, but the results have been inconsistent.

Objective
This systematic review of non-experimental studies aims to investigate the prevalence of post-stroke depression and the association between post-stroke depression and functional outcomes.

Method
A search of PubMed, MEDLINE, Web of Science, and CINAHL Plus with Full Text was carried out from inception until January 2024. The literature was screened using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, with relevant papers included. We extracted data from non-experimental studies that examined associations between PSD and functional outcomes. The Joanna Briggs Institute for systematic reviews was used for critical appraisal.

Results
Twenty-one studies met the study criteria, including sixteen cohort studies, four cross-sectional studies, and one case-control study. PSD prevalences ranged from 12.2% to 32.2% in the first two weeks, 17.9 to 35.5% in the first month, and 10.4% to 32.0% in the third month following a stroke. Functional outcomes were evaluated in four domains: degree of dependence, basic activity of daily living, instrumental activity of daily living, and physical and cognitive function. Significant associations between PSD and functional outcomes were identified after controlling potential factors such as age, comorbidities, and stroke severity. PSD had negative associations with functional outcomes in all four measure domains from one month to five years after a stroke. Depression treatment showed positive results on functional outcomes in stroke patients.

Conclusion
PSD prevalence was high in the first three months after stroke. PSD is significantly associated with poor functional outcomes. PSD assessment and management should be performed on a frequent basis in the early stages of stroke to achieve the best possible functional recovery.
A multimodal couple-coping intervention for enhancing sexual adjustment among breast cancer women: Study protocol for a randomised controlled trial
Authors: Chow Ka Ming , Chan Carmen Wing Han , Choi Kai Chow , McCarthy Alexandra Leigh 
Published: August 2024

Aim
To investigate the effects of a multimodal couple-based sexual health intervention for premenopausal women treated for breast cancer and their partners to provide personalised psychosexual care, and to understand participants’ experience of, and adherence to, the intervention.

Methods
This is an assessor-blinded, randomised controlled trial. Premenopausal women treated for breast cancer (N = 160) and their partners will be recruited. Dyads will be randomised into an intervention (n = 80) or attention control (n = 80) group. The intervention group will receive the multimodal couple-based sexual health intervention over eight weeks. The intervention comprises five face-to-face and virtual individual couple counselling sessions combined with online reading, a chat-based discussion forum, and telephone calls. The intervention is based on level I-II evidence and a robust theoretical framework. The attention control group will receive usual care plus telephone calls comprising general greetings and reminders to complete follow-up surveys. Sexual adjustment, relationship quality and quality of life will be measured at baseline, after completion of the intervention, three months and six months post-intervention. The project will adhere to the CONSORT-EHEALTH checklist. Qualitative interviews will explore the participants’ experience of, and adherence to, the intervention.

Discussion
This study will provide the first pragmatic evidence of the effectiveness of a multimodal couple-coping intervention to support premenopausal women and their partners to improve sexuality, relationship quality and quality of life after treatment for breast cancer.

Implications for the profession and /or patient care
Sexual health is a neglected area in clinical practice, for patients and partners. The ever-growing population of women treated for breast cancer at younger age has created a more pressing need for the development of tailored sexual health interventions. If effective, this intervention could be incorporated into routine cancer care to provide better support and care for this patient population to enhance sexual health, intimacy and overall well-being.

Trial registration
ISRCTN35481498; prospectively registered on 08/05/2023.
Tamsulosin use in benign prostatic hyperplasia and risks of Parkinson’s disease, Alzheimer’s disease and mortality: An observational cohort study of elderly Medicare enrollees
Authors: Fung Kin Wah , Baye Fitsum , Baik Seo H. , McDonald Clement J. 
Published: August 2024

Purpose
To study the effects of benign prostatic hyperplasia treatments, namely: alpha-adrenergic receptor blockers, 5-alpha-reductase inhibitors and phosphodiesterase-5 inhibitors on the risk of Parkinson’s disease, Alzheimer’s disease and mortality.

Materials and methods
All male Medicare enrollees aged 65 or above who were diagnosed with benign prostatic hyperplasia and received one of the study drugs between 2007–2020 were followed-up for the three outcomes. We used Cox regression analysis to assess the relative risk of each of the outcomes for each study drug compared to the most prescribed drug, tamsulosin, while controlling for demographic, socioeconomic and comorbidity factors.

Results and conclusions
The study analyzed 1.1 million patients for a mean follow-up period of 3.1 years from being prescribed one of the study drugs. For all outcomes, patients on tamsulosin were used as the reference for comparison. For mortality, alfuzosin was associated with 27% risk reduction (HR 0.73, 95%CI 0.68–0.78), and doxazosin with 6% risk reduction (HR 0.94, 95%CI 0.91–0.97). For Parkinson’s disease, terazosin was associated with 26% risk reduction (HR 0.74, 95%CI 0.66–0.83), and doxazosin with 21% risk reduction (HR 0.79, 95%CI 0.72–0.88). For Alzheimer’s disease, terazosin was associated with 27% risk reduction (HR 0.73, 95%CI 0.65–0.82), and doxazosin with 16% risk reduction (HR 0.84, 95%CI 0.76–0.92). Tadalafil was associated with risk reduction (27–40%) in all 3 outcomes. More research is needed to elucidate the underlying mechanisms of these observations. Given the availability of safer alternatives for treating benign prostatic hyperplasia, caution should be exercised when using tamsulosin in elderly patients, especially those with an increased risk of developing neurodegenerative diseases.
Risk factors and strategies for relapse prevention among individuals living with serious mental illness in South Africa: Qualitative inquiry from patients’ and caregivers’ perspectives
Authors: Mlay Joyce Protas , Naidu Thirusha , Ramlall Suvira , Mhlungu Sbusisiwe Sandra , Zondi Makhosazane , Lessells Richard , Manuel Jennifer I. , Tomita Andrew 
Published: August 2024

Introduction
Relapse among individuals with serious mental illnesses in resource-limited contexts, including South Africa, is a significant concern. To date, the risks for relapse among this population is well documented, but little is known about prevention strategies to reduce its occurrence in these resource-limited settings. Therefore, this qualitative study explores the risk factors and strategies for relapse prevention from the patients’ and caregivers’ perspectives.

Methods
We conducted audio-recorded face-to-face in-depth interviews to capture the lived experience of relapse of inpatient study participants with serious mental illness (N = 24) at a public specialized psychiatry hospital in South Africa and their caregivers (N = 6). We conducted an inductive thematic analysis with two pre-specified themes (risk factors for relapse and strategies for prevention), with the codes devised from the data.

Results
Six sub-themes were identified from the analysis within the two pre-specified themes(Risk factors and strategies for relapse prevention): personal-related, family-related, and health system-related risk factors and strategies for preventing relapse, respectively. To highlight some essential findings, the importance of motivation for drug adherence, family involvement, and availability of anti-psychotic drugs in public health care were noted. More importantly, this study identified important cultural complexities where traditional healers play a significant role in some cultural understanding and treatment of mental illness, affecting medication adherence.

Conclusion
This study calls for people-centered mental health care delivery in a public health system that listens to the voice of concern, including cultural challenges, and implements meaningful support that matters most to the patient and their family/caregivers.
Examination of the proportion and characteristics of cognitive function changes during hospitalization in patients with cardiovascular diseases
Authors: Shimoda Takahiro , Suzuki Shinzi , Mizukoshi Daisuke , Saori Wada , Yokoshima Erina , Terai Tomoko 
Published: August 2024

Objective
Cognitive function decline is influenced by cardiovascular diseases and associated risk factors. However, changes in the cognitive function of patients with cardiovascular diseases during hospitalization and the factors influencing these changes remain unclear. This study elucidated the proportion and characteristics of changes in cognitive function during hospitalization in patients with cardiovascular diseases.

Methods
We conducted cognitive function assessments at admission and discharge for patients with cardiovascular diseases. Using the Mini-Mental State Examination (MMSE) and the Japanese version of the Montreal Cognitive Assessment (MoCA-J), we categorized the patients into cognitive impairment, mild cognitive impairment (MCI), and non-cognitive impairment. Changes in MMSE or MoCA-J scores of ≥2 points at discharge were classified as improvement or decline, and all others as maintenance.

Results
The cognitive impairment, MCI, and non-cognitive impairment categories comprised 215 (41.3%), 224 (40.2%), and 103 (18.5%) patients, respectively. The results of the cognitive function assessment at the time of discharge classified 90 patients (35.9%) into the maintenance group, 117 (46.6%) into the improvement group, and 44 (17.5%) into the decline group based on changes during hospitalization. There was a statistically significant difference among the three groups only in cognitive function at admission (P = 0.026). In multivariate analysis, those with MCI or cognitive impairment at admission and younger patients were associated with improved cognitive function during hospitalization. No factors were extracted that showed statistically significant associations with cognitive decline.

Conclusion
Approximately half of the patients with cardiovascular disease experienced improvements in cognitive function during hospitalization, while approximately 20% showed a decline in cognitive function during the same period. These findings demonstrate the importance of assessing cognitive changes in hospitalized patients with cardiovascular disease. Future studies are needed to identify factors associated with changes in cognitive function.
Beyond Access: Factors Influencing Students' Utilization of Educational Technologies at Selected High Schools in Addis Ababa – A Survey Analysis
Authors: Yimmam Anteneh 
Published: August 2024

Relevant studies showed the positive influence educational technologies have on students' academic experience. This study examined how students in Addis Ababa's public, private, and international high schools use Educational Technologies to improve their academics. Thirty random schools were surveyed, and the collected data were analyzed using descriptive, regression, and inferential statistics to address the objectives of the study. The online survey had more than a thousand views per school, showing high accessibility of both the internet and devices. Most of the respondents used educational technologies. 18.4% of students who didn’t use edtech attributed it to a lack of guidance from their teachers. In Ethiopia and similar countries, many studies, including this one, found that teachers were not using educational technologies.
This study confirmed that using Edtech increased academic motivation. Interestingly, educational technologies were used equally irrespective of whether students found their daily lessons “applicable” or not. This contradicted other studies, which found that the use of e-learning in developing countries was significantly affected by their perceived utility. Similarly, there were only a few significant advantages or disadvantages of enrolling in any of the three high school categories. For instance, students learning in public schools showed a significant increase in social media use while international high school students got significantly better guidance on using edtech compared to their public counterparts.
Współczesny styl życia przyczyną zachowań ryzykownych, w tym zażywania środków psychoaktywnych – na przykładzie NSP
Authors: Nosko Damian 
Published: August 2024

The article addresses one of the most difficult problems to solve at present, i.e. addiction and its causes. The author, Dr Damian Nosko, draws a close parallel between addiction to psychoactive substances and young people’s sense of insurmountable deficits. This most often results from a perceived clash, difficult to rationalize and often impossible to name, between expectations and authentic possibilities for realizing dreams and achieving goals. The essence of the reflections concerns an area related to engaging in risky behaviors, including reaching for psychoactive drugs as an outlet for emotions, forgetting about problems, and a substitute for pursuing real fulfilment. While the author ascribes a huge role in shaping socially desirable attitudes of youth during adolescence to family, they admit that the pace of life, consumerism, dependence on technological achievements and on mass media, as well as a lack of conclusive legal regulations do not facilitate the struggle for the well-being of young people and create a convenient possibility of raising a next generation of unfulfilled adults who are also predisposed to addictions.
Phenolic compounds, chemical oxygen demand and total carbon organic removal from olive mill wastewater by activated persulfate oxidation using full factorial design
Authors: Iboukhoulef Hamida , Hamidouchi Fatma , Malki Katia , Amrane Abdeltif , Sebaoui Ouiza , Begbeg Amel , Amghar Fahima 
Published: August 2024

Abstract
This study investigated phenolic compounds (PC), chemical oxygen demand (COD) and total carbon organic total (TOC) removal from olive mill wastewater OMW via activated persulfate oxidation. Persulfate (PS,

S
2

O
8

2
−

${\mathrm{S}}_{2}{\mathrm{O}}_{8}^{2-}$

) was activated by thermal and transition metal to form sulfate radical (

S

O
4

·
−

$\mathrm{S}{\mathrm{O}}_{4}^{{\cdot}-}$

). A mathematical model was developed, and the process variables, namely oxidant dose (0.05 and 0.1 g L−1), type of catalyst (Fe2+, Cu2+), time of treatment (5 and 20 min) and temperature (25 and 45 °C) and their interaction were examined using a full factorial design methodology 24. The results indicated that activation methods are efficient for reduction of PC and COD in OMW. Under conditions maximizing responses, there was a considerable increase in PC, COD and TOC removal (44.73 %, 62.39 % and 95.13 % respectively). The correlation coefficient values of the polynomial model were found to be 90 % (CP removal) and 86 % (COD removal). The predicted values obtained using the response functions agreed well with the experimental data.