bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basis-independent quantum coherence and its distribution under relativistic motion
Authors: Du Ming-Ming , Li Hong-Wei , Tao Zhen , Shen Shu-Ting , Yan Xiao-Jing , Li Xi-Yun , Zhong Wei , Sheng Yu-Bo , Zhou Lan 
Published: August 2024

AbstractRecent studies have increasingly focused on the effect of relativistic motion on quantum coherence. Prior research predominantly examined the influence of relative motion on basis-dependent quantum coherence, underscoring its susceptibility to decoherence under accelerated conditions. Yet, the effect of relativistic motion on basis-independent quantum coherence, which is critical for understanding the intrinsic quantum features of a system, remains an interesting open question. This paper addresses this question by examining how total, collective, and localized coherence are affected by acceleration and coupling strength. Our analysis reveals that both total and collective coherence significantly decrease with increasing acceleration and coupling strength, ultimately vanishing at high levels of acceleration. This underscores the profound impact of Unruh thermal noise. Conversely, localized coherence exhibits relative stability, decreasing to zero only under the extreme condition of infinite acceleration. Moreover, we demonstrate that collective, localized, and basis-independent coherence collectively satisfy the triangle inequality. These findings are crucial for enhancing our understanding of quantum information dynamics in environments subjected to high acceleration and offer valuable insights on the behavior of quantum coherence under relativistic conditions.
Synthesis, characterization and correlation studies on the Ni–Zn–Mn ferrite as a photocatalyst
Authors: Elmekawy Ahmed , Abdel-Hakim M. , El Hussiny F. , Farag G. , Hemeda O. M. , Mosaad M. M. , Sharshar T. , Henaish A. M. A. 
Published: August 2024

AbstractSamples of Ni0.3Zn0.7−xMnxFe2O4(x = 0, 0.15, 0.25, 0.35, 0.45, 0.55) nanoparticles (NPs) were synthesized by auto-combustion flash method. These ferrites were used as catalysts for photodegradation of methylene blue (MB) dye utilizing visible light energy. Structural analysis was carried out using the X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy, while nanoparticle dimensions were elucidated through transmission electron microscopy (TEM). The magnetic and optical behaviours were unveiled via vibrating sample magnetometer and UV–VIS spectroscopy, respectively. The XRD outcomes established the presence of a cubic spinel-type structure for the studied ferrite samples. The FTIR spectra unveiled two absorption characteristic bands of the spinel ferrite. TEM images revealed nanoscale dimensions of ferrite NPs with the range from 21.1 to 51.8 nm. The optical features exhibited an indirect band gap energy spanning from 4.25 to 4.36 eV. Magnetization behaviour displayed a sinusoidal trend corresponding to varying Mn concentrations. The ferrite NPs catalyst (10 mg) yield photodegradation efficiency ranged from 22.8 to 33.9% for 100 ml MB dye solution after 120 min of light irradiation. The effects of dye concentration and catalyst dose on the degradation efficiency were examined using the Ni0.3Zn0.35Mn0.35Fe2O4catalyst with highest degradation (= 33.9%). On the other hand, the dependence of the degradation efficiency on the structure, morphological, magnetic and optical properties of the photocatalyst was investigated. The findings of this study underscore the potential of the prepared ferrite nanoparticles for advanced applications in environmental restoration.Graphical abstract
Traumatic Disruption of Profunda Femoris Artery Branch Following Treatment of an Intertrochanteric Hip Fracture With a Cephalomedullary Nail
Authors: Beckett Nathan C. , Haglin Jack , Van Schuyver Paul , Spangehl Mark J. , Kalani Maziyar A. , Lyons Mark K. , Bathini Abhijith R. , Bingham Joshua S. 
Published: August 2024

Introduction: Surgical management of intertrochanteric hip fractures is a common surgery with low rates of intraoperative complications. Vascular injuries are exceptionally rare when placing an intramedullary nail without open reduction. There are very few reported cases of direct arterial injury and active bleed at the level of the distal interlocking screw following closed reduction and intramedullary nailing of a hip fracture. We report one such case.Case Presentation: An 88‐year‐old female presented to the emergency department with a left intertrochanteric hip fracture. Closed reduction with a cephalomedullary nail fixation of the left hip fracture occurred as planned without any obvious intraoperative technical issues. The patient remained stable intraoperatively. No open reduction was required. Postoperatively, the patient developed hemorrhagic shock and required massive transfusion protocol. Angiography demonstrated an intramuscular hematoma at the level of the distal intramedullary nail interlocking screw with active extravasation. The patient subsequently required embolization. Nine days following surgery, she began Eliquis for DVT prophylaxis and was ambulating independently with signs of hematoma resolution.Discussion: Profunda femoris artery injury can stem from various mechanisms during surgery. Atherosclerosis places patients at a higher risk of complication due to rigid vessels. In this case, it is believed that drilling beyond the medial femoral cortex led to the arterial injury.Conclusion: Care should be taken to prevent drills from plunging beyond the medial femoral cortex during surgery. Cautious observation of patient’s vitals and clinical course can allow for early detection of vascular complication.
Integrative Multiomics in the Lung Reveals a Protective Role of Asporin in Pulmonary Arterial Hypertension
Authors: Hong Jason , Medzikovic Lejla , Sun Wasila , Wong Brenda , Ruffenach Grégoire , Rhodes Christopher J. , Brownstein Adam , Liang Lloyd L. , Aryan Laila , Li Min , Vadgama Arjun , Kurt Zeyneb , Schwantes-An Tae-Hwi , Mickler Elizabeth A. , Gräf Stefan , Eyries Mélanie , Lutz Katie A. , Pauciulo Michael W. , Trembath Richard C. , Perros Frédéric , Montani David , Morrell Nicholas W. , Soubrier Florent , Wilkins Martin R. , Nichols William C. , Aldred Micheala A. , Desai Ankit A. , Trégouët David-Alexandre , Umar Soban , Saggar Rajan , Channick Richard , Tuder Rubin M. , Geraci Mark W. , Stearman Robert S. , Yang Xia , Eghbali Mansoureh 
Published: August 2024

BACKGROUND:
Integrative multiomics can elucidate pulmonary arterial hypertension (PAH) pathobiology, but procuring human PAH lung samples is rare.

METHODS:
We leveraged transcriptomic profiling and deep phenotyping of the largest multicenter PAH lung biobank to date (96 disease and 52 control) by integration with clinicopathologic data, genome-wide association studies, Bayesian regulatory networks, single-cell transcriptomics, and pharmacotranscriptomics.

RESULTS:

We identified 2 potentially protective gene network modules associated with vascular cells, and we validated
ASPN
, coding for asporin, as a key hub gene that is upregulated as a compensatory response to counteract PAH. We found that asporin is upregulated in lungs and plasma of multiple independent PAH cohorts and correlates with reduced PAH severity. We show that asporin inhibits proliferation and transforming growth factor–β/phosphorylated SMAD2/3 signaling in pulmonary artery smooth muscle cells from PAH lungs. We demonstrate in Sugen-hypoxia rats that
ASPN
knockdown exacerbated PAH and recombinant asporin attenuated PAH.

CONCLUSIONS:
Our integrative systems biology approach to dissect the PAH lung transcriptome uncovered asporin as a novel protective target with therapeutic potential in PAH.
Predictors and risk factors of pulmonary embolism after total hip arthroplasty: an NSQIP study
Authors: Bulut Halil , Maestre Maria Jose , Tomey Daniel 
Published: August 2024

Introduction: Pulmonary embolism (PE) is a well-known contributor to morbidity after total hip arthroplasty (THA). Considerable efforts have been invested in reducing PE occurrence through pharmacological and perioperative interventions. Nonetheless, the effectiveness of these strategies in reducing the incidence and overall mortality associated with pulmonary embolism events remains a matter of debate. Therefore, identifying risky patients has been gaining importance. Methods: We utilised data from the National Surgical Quality Improvement Program (NSQIP) participant usage file (PUF) database spanning the years 2016 to 2021. All preoperative parameters were analysed with chi-square afterwards, meaningful ones were run with logistic regression test. Results: A study examined factors influencing pulmonary embolism (PE) prevalence in 235,393 total hip arthroplasty patients. Univariate analysis identified significant associations between PE and female gender, diabetes, smoking, dyspnea, CHF, COPD, hypertension (HT), bleeding disorders, disseminated cancer, steroid use, and functional health status. Multivariate analysis revealed male gender as protective, while COPD, hypertension, and disseminated cancer increased PE risk. Notably, smoking appeared protective. PE patients had higher return-to-operation rates (41.7% vs. 2.2%) but similar 30-day mortality (0.2% vs. 0.04%), though mortality’s odds ratio was not significant. Conclusions: Our findings suggest that certain patient characteristics, such as COPD and metastatic malignancy, significantly influence the likelihood of PE development.
Dynamic Resistance and Energy Absorption of Sandwich Beam via a Micro-Topology Optimization
Authors: Li Shiqiang , Li Yuwei , Ma Xiaomin , Fang Jianguang , Liu Zhifang , Wang Zhihua 
Published: August 2024

AbstractThe current research of sandwich structures under dynamic loading mainly focus on the response characteristic of structure. The micro-topology of core layers would sufficiently influence the property of sandwich structure. However, the micro deformation and topology mechanism of structural deformation and energy absorption are unclear. In this paper, based on the bi-directional evolutionary structural optimization method and periodic base cell (PBC) technology, a topology optimization frame work is proposed to optimize the core layer of sandwich beams. The objective of the present optimization problem is to maximize shear stiffness of PBC with a volume constraint. The effects of the volume fraction, filter radius, and initial PBC aspect ratio on the micro-topology of the core were discussed. The dynamic response process, core compression, and energy absorption capacity of the sandwich beams under blast impact loading were analyzed by the finite element method. The results demonstrated that the over-pressure action stage was coupled with the core compression stage. Under the same loading and mass per unit area, the sandwich beam with a 20% volume fraction core layer had the best blast resistance. The filter radius has a slight effect on the shear stiffness and blast resistances of the sandwich beams. But increasing the filter radius could slightly improve the bending stiffness. Upon changing the initial PBC aspect ratio, there are three ways for PBC evolution: The first is to change the angle between the adjacent bars, the second is to further form holes in the bars, and the third is to combine the first two ways. However, not all three ways can improve the energy absorption capacity of the structure. Changing the aspect ratio of the PBC arbitrarily may lead to worse results. More studies are necessary for further detailed optimization. This research proposes a new topology sandwich beam structure by micro-topology optimization, which has sufficient shear stiffness. The micro mechanism of structural energy absorption is clarified, it is significant for structural energy absorption design.
Financing pandemic prevention, preparedness and response: lessons learned and perspectives for future
Authors: Ndembi Nicaise , Dereje Nebiyu , Nonvignon Justice , Aragaw Merawi , Raji Tajudeen , Fallah Mosoka Papa , Abdulaziz Mohammed , Djoudalbaye Benjamin , Aluso Aggrey , Boum II Yap , Mwaba Gwen , Shisana Olive , Ngongo Ngashi , Kaseya Jean 
Published: August 2024

Abstract
Background
The attainment of global health security goals and universal health coverage will remain a mirage unless African health systems are adequately funded to improve resilience to public health emergencies. The COVID-19 pandemic exposed the global inequity in accessing medical countermeasures, leaving African countries far behind. As we anticipate the next pandemic, improving investments in health systems to adequately finance pandemic prevention, preparedness, and response (PPPR) promptly, ensuring equity and access to medical countermeasures, is crucial. In this article, we analyze the African and global pandemic financing initiatives and put ways forward for policymakers and the global health community to consider.

Methods
This article is based on a rapid literature review and desk review of various PPPR financing mechanisms in Africa and globally. Consultation of leaders and experts in the area and scrutinization of various related meeting reports and decisions have been carried out.

Main text
The African Union (AU) has demonstrated various innovative financing mechanisms to mitigate the impacts of public health emergencies in the continent. To improve equal access to the COVID-19 medical countermeasures, the AU launched Africa Medical Supplies Platform (AMSP) and Africa Vaccine Acquisition Trust (AVAT). These financing initiatives were instrumental in mitigating the impacts of COVID-19 and their lessons can be capitalized as we make efforts for PPPR. The COVID-19 Response Fund, subsequently converted into the African Epidemics Fund (AEF), is another innovative financing mechanism to ensure sustainable and self-reliant PPPR efforts. The global initiatives for financing PPPR include the Pandemic Emergency Financing Facility (PEF) and the Pandemic Fund. The PEF was criticized for its inadequacy in building resilient health systems, primarily because the fund ignored the prevention and preparedness items. The Pandemic Fund is also being criticized for its suboptimal emphasis on the response aspect of the pandemic and non-inclusive governance structure.

Conclusions
To ensure optimal financing for PPPR, we call upon the global health community and decision-makers to focus on the harmonization of financing efforts for PPPR, make regional financing mechanisms central to global PPPR financing efforts, and ensure the inclusivity of international finance governance systems.
Sergentomyia khawi: a potential vector for Leishmania and Trypanosoma parasites affecting humans and animals and insecticide resistance status in endemic areas of Songkhla, southern Thailand
Authors: Phumee Atchara , Sutthanont Nataya , Chitcharoen Suwalak , Sawaswong Vorthon , Boonserm Rungfar , Ayuyoe Pattama , Cantos-Barreda Ana , Siriyasatien Padet 
Published: August 2024

Abstract
Background
Sand flies serve as crucial vectors in various medical and veterinary diseases. Sand fly-borne diseases pose a significant public health burden globally, as the causative agents can infect a diverse range of hosts, leading to severe consequences such as leishmaniasis and sand fly fever. Additionally, the widespread use of insecticides for agricultural purposes and mosquito control is not specifically targeted at sand flies, potentially leading to resistance development. We investigated sand fly species, their potential role as vectors of various parasitic agents, and insecticide resistance in the endemic regions of Natawi and Sadao districts in Songkhla, Thailand.

Methods
Sand flies were collected using CDC light traps. The collected sand flies were then identified to species level using molecular techniques. Subsequent analyses included the detection of pathogens and the identification of pyrethroid resistance mutations within the voltage-sensitive sodium channel (Vgsc) domain IIS6 gene, followed by sequence analysis.

Results
The study identified nine sand fly species belonging to the genera Phlebotomus and Sergentomyia. The DNA of Sergentomyia khawi was the only species found to test positive for one sample of Leishmania orientalis in Sadao district. This finding represents the first detection of L. orientalis in Thailand. Moreover, three samples of Leishmania martiniquensis and four samples of Trypanosoma sp. were found in the Natawi district. No I1011M, L1014F/S, V1016G, or F1020S mutations were detected in Vgsc gene.

Conclusions
The results of this study provide valuable information on sand fly species and the continuous circulation of Leishmania spp. and Trypanosoma spp. in Songkhla, southern Thailand. Moreover, the development of geo-spatial information on vectors, parasites, and insecticide resistance in sand flies has the potential to provide well-informed risk assessments and evidence-based guidance for targeted vector control in Thailand. These results can serve as a foundation for integrating the One Health approach, which is crucial for disease control, considering the diverse ecological interactions among human and/or animal reservoir hosts, parasites, and sand fly vectors.

Graphic Abstract
The response to influenza vaccination is associated with DNA methylation-driven regulation of T cell innate antiviral pathways
Authors: Fu Hongxiang , Pickering Harry , Rubbi Liudmilla , Ross Ted M. , Zhou Wanding , Reed Elaine F. , Pellegrini Matteo 
Published: August 2024

Abstract
Background
The effect of vaccination on the epigenome remains poorly characterized. In previous research, we identified an association between seroprotection against influenza and DNA methylation at sites associated with the RIG-1 signaling pathway, which recognizes viral double-stranded RNA and leads to a type I interferon response. However, these studies did not fully account for confounding factors including age, gender, and BMI, along with changes in cell-type composition.

Results
Here, we studied the influenza vaccine response in a longitudinal cohort vaccinated over two consecutive years (2019–2020 and 2020–2021), using peripheral blood mononuclear cells and a targeted DNA methylation approach. To address the effects of multiple factors on the epigenome, we designed a multivariate multiple regression model that included seroprotection levels as quantified by the hemagglutination-inhibition (HAI) assay test.

Conclusions
Our findings indicate that 179 methylation sites can be combined as potential signatures to predict seroprotection. These sites were not only enriched for genes involved in the regulation of the RIG-I signaling pathway, as found previously, but also enriched for other genes associated with innate immunity to viruses and the transcription factor binding sites of BRD4, which is known to impact T cell memory. We propose a model to suggest that the RIG-I pathway and BRD4 could potentially be modulated to improve immunization strategies.
Modes of administration of nitric oxide devices and ventilators flow-by impact the delivery of pre-determined concentrations
Authors: Vuillermoz Alice , Lefranc Mathilde , Prouvez Nathan , Brault Clément , Zerbib Yoann , Schmitt Mary , Forel Jean-Marie , Le Tutour Mathieu , Lesimple Arnaud , Mercat Alain , Richard Jean-Christophe , Beloncle François M. 
Published: August 2024

Abstract
Background
Nitric oxide (NO) is a strong vasodilator, selectively directed on pulmonary circulation through inhaled administration. In adult intensive care units (ICU), it is mainly used for refractory hypoxemia in mechanically ventilated patients. Several medical delivery devices have been developed to deliver inhaled nitric oxide (iNO). The main purpose of those devices is to guarantee an accurate inspiratory NO concentration, whatever the ventilator used, with NO2 concentrations lower than 0.3 ppm. We hypothesized that the performances of the different available iNO delivery systems could depend on their working principle and could be influenced by the ventilator settings. The objective of this study was to assess the accuracy of seven different iNO-devices combined with different ICU ventilators’ flow-by to reach inspiratory NO concentration targets and to evaluate their potential risk of toxicity.

Methods
We tested seven iNO-devices on a test-lung connected to distinct ICU ventilators offering four different levels of flow-by. We measured the flow in the inspiratory limb of the patient circuit and the airway pressure. The nitric oxide/nitrogen (NO/N2) flow was measured on the administration line of the iNO-devices. NO and NO2 concentrations were measured in the test-lung using an electrochemical analyzer.

Results
We identified three iNO-device generations based on the way they deliver NO flow: “Continuous”, “Sequential to inspiratory phase” (I-Sequential) and “Proportional to inspiratory and expiratory ventilator flow” (Proportional). Median accuracy of iNO concentration measured in the test lung was 2% (interquartile range, IQR -19; 36), -23% (IQR -29; -17) and 0% (IQR -2; 0) with Continuous, I-Sequential and Proportional devices, respectively. Increased ventilator flow-by resulted in decreased iNO concentration in the test-lung with Continuous and I-Sequential devices, but not with Proportional ones. NO2 formation measured to assess potential risks of toxicity never exceeded the predefined safety target of 0.5 ppm. However, NO2 concentrations higher than or equal to 0.3 ppm, a concentration that can cause bronchoconstriction, were observed in 19% of the different configurations.

Conclusion
We identified three different generations of iNO-devices, based on their gas administration modalities, that were associated with highly variable iNO concentrations’ accuracy. Ventilator’s flow by significantly impacted iNO concentration. Only the Proportional devices permitted to accurately deliver iNO whatever the conditions and the ventilators tested.
Study on the control effectiveness of relative humidity by various ventilation systems for the conservation of cultural relics
Authors: Liu Benli , He Chenchen , Zhang Guobin , Xu Ruihong , Zhan Hongtao , Wu Fasi , He Dongpeng 
Published: August 2024

Abstract
The Dadiwan F901 site, boasting a history of over 5000 years, stands as the largest and most intricately crafted large-scale housing structure from China’s prehistoric era. The early renovation efforts, incorporating a sealed glass curtain wall, led to a continuous rise in relative humidity within the site, triggering outbreaks of microbial diseases. Subsequent measures successfully restored stability to the thermal and humid environment. This paper employs on-site real-time environmental monitoring and numerical simulation methods to assess the ventilation effectiveness and relative humidity changes before and after multiple interior modifications of the Dadiwan F901 site museum. The results indicate that the fully enclosed glass curtain wall can suppress the dependence of indoor humidity fluctuations on external weather fluctuations but has generated unintended consequences, leading to increased air relative humidity and even reaching saturation in the museum space. The strategic deployment of louvered windows and duct fans proved effective in enhancing internal airflow dynamics and overall air exchange capacity. It was possible to ensure that the relative humidity inside the site remained at approximately 70%, meeting the essential requirements for the preservation of cultural relics. This study is of great significance for alleviating the deterioration problem of enclosed exhibition halls of earthen relics.

Graphical Abstract