bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary vein thrombosis in COVID-19 patient with chronic obstructive pulmonary disease: a case report
Authors: Alaazmi Noora Hamad , Yusuf Khalifa Abdulrahman , Al-Madani Abdulrahman Hasan , Shehata Ghada Hassan , Al-Fadhel Hani Ebrahim 
Published: July 2024

Abstract
Background
Pulmonary vein thrombosis is a rare condition with a non-specific presentation with multiple underlying etiologies such as malignancy or lung surgery. In rare instances, no etiology could be encountered. Instead, it has a broad spectrum of clinical manifestations, from dyspnea to lung infarction with a compromise to hemodynamics.

Case presentation
A 71 years old male with a history of shortness of breath. The patient tested positive for COVID-19; the prolonged exertional fatigue led to undergoing CTPA (CT pulmonary angiography), which revealed pulmonary vein thrombosis. This case emphasizes the importance of maintaining a high index of clinical suspicion in the absence of other possible diagnoses. Furthermore, diagnostic work-up and treatment strategies depend highly on the patient’s presentation and risk factors.

Conclusions
Pulmonary vein thrombosis is an infrequent entity reported in the medical literature and underdiagnosed because of its ambiguous presentation. Early diagnosis is paramount to prevent complications.
Pembrolizumab Plus Carboplatin and Paclitaxel as First-Line Therapy for Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma (KEYNOTE-B10): A Single-Arm Phase IV Trial
Authors: Dzienis Marcin , Cundom Juan , Fuentes Christian Sebastian , Spreafico Anna , Nordlinger Melanie , Pastor Andrea Viviana , Alesi Erin , Neki Anterpreet , Fung Andrea S. , Figueiredo Lima Iane Pinto , Oppelt Peter , da Cunha Junior Geraldo Felicio , Burtness Barbara , Franke Fabio Andre , Tseng Jennifer E. , Joshi Abhishek , McCarthy Joy , Swaby Ramona , Sidi Yulia , Gumuscu Burak , Naicker Niroshini , de Castro Gilberto 
Published: July 2024

PURPOSE

Standard-of-care first-line treatment for recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) is pembrolizumab plus platinum and fluorouracil (FU). However, FU is associated with potential challenges (continuous 4-day infusion, high administration costs, and cardiovascular and gastrointestinal toxicities), creating a clinical need for alternative chemotherapy combinations. We evaluated the efficacy and safety of first-line pembrolizumab plus carboplatin and paclitaxel for R/M HNSCC in the open-label, single-arm, phase IV KEYNOTE-B10 study (ClinicalTrials.gov identifier:
NCT04489888
).

METHODS

Eligible adults had previously untreated, histologically or cytologically confirmed R/M HNSCC regardless of PD-L1 status, measurable disease per RECIST v1.1 by blinded independent central review (BICR), and an Eastern Cooperative Oncology Group performance status of 0 or 1. Patients received pembrolizumab 200 mg intravenously once every 3 weeks for ≤35 cycles and carboplatin AUC 5 mg/mL/min intravenously once every 3 weeks for ≤6 cycles and investigator's choice of paclitaxel 100 mg/m
2
on days 1 and 8 or 175 mg/m
2
on day 1, intravenously once every 3 weeks. The primary end point was objective response rate per RECIST v1.1 by BICR.

RESULTS
Between October 27, 2020, and April 29, 2022, 149 patients were screened and 101 received treatment. As of February 20, 2023, the median follow-up was 18.9 months (range, 9.1-27.0). At this final analysis, 49 (49%) of 101 patients had an objective response (95% CI, 38.4 to 58.7), including seven patients (7%) with a confirmed complete response. Of the 101 treated patients, grade 3-5 and serious treatment-related adverse events occurred in 76 (75%) and 27 (27%), respectively. There were no new safety signals.

CONCLUSION
Pembrolizumab plus carboplatin and paclitaxel showed promising antitumor activity and a manageable safety profile in first-line R/M HNSCC, suggesting this combination may be an alternative option for this patient population.
The Role of Watertight Dural Closure in Supratentorial Craniotomy: A Systematic Review and Meta-Analysis
Authors: Gibbon Frederico L. , Lindner Rafaela J. , Silva Manuela T. , Gago Guilherme , Chaddad-Neto Feres 
Published: July 2024

BACKGROUND AND OBJECTIVE:
The idea of watertight dural closure (WTDC) seems extremely obvious to avoid complications such as cerebrospinal fluid (CSF) leak and infection, especially in spinal and posterior fossa surgeries. Nonetheless, several studies have shown that leaving the dura open is not associated with an increased risk of complications. The aim of this systematic review and meta-analysis is to compare non-WTDC and WTDC in patients undergoing supratentorial craniotomy regarding the risk of postoperative complications.

METHODS:
We searched PubMed, Web of Science, Embase, and Cochrane for randomized control trials and observational studies comparing non-WTDC with WTDC in patients undergoing supratentorial craniotomy. Outcomes of interest were CSF leak, overall infection, meningitis, and subgaleal fluid collection (SFC). Statistical analysis was performed using RStudio 2023.12.1 + 402. Heterogeneity was assessed using I2 statistics.

RESULTS:
Of 1541 potential articles, 7 met the inclusion criteria. The review comprised 3 randomized control trials, 1 prospective study, and 3 retrospective cohort studies. Among the 1619 patients, 766 (47.3%) and 853 (52.7%) patients were in the non-WTDC and WTDC groups, respectively. There was no significant difference in CSF leak between the non-WTDC and WTDC groups (risk ratio [RR] 1.61; 95% CI 0.68-3.77; P = .276; I2 = 0%). Furthermore, we did not find significant differences in overall infection (RR 1.62; 95% CI 0.95-2.76; P = .078; I2 = 4%), meningitis (RR 1.87; 95% CI 0.64-5.46; P = .251; I2 = 0%), and SFC (RR 1.53; 95% CI 0.64-3.65; P = .342; I2 = 52%) between the non-WTDC and WTDC groups.

CONCLUSION:
These findings suggest that non-WTDC is a safe method and is not associated with an increased risk of CSF leak, overall infection, meningitis, and SFC compared with WTDC.
Loss of Tob1 promotes muscle regeneration through muscle stem cell expansion
Authors: Kitajima Yasuo , Yoshioka Kiyoshi , Mikumo Yoko , Ohki Shun , Maehara Kazumitsu , Ohkawa Yasuyuki , Ono Yusuke 
Published: July 2024

ABSTRACT
Muscle stem cells (MuSCs) play an indispensable role in postnatal muscle growth and hypertrophy in adults. MuSCs also retain a highly regenerative capacity and are therefore considered a promising stem cell source for regenerative therapy for muscle diseases. In this study, we identify tumor-suppressor protein Tob1 as a Pax7 target protein that negatively controls the population expansion of MuSCs. Tob1 protein is undetectable in the quiescent state but is upregulated during activation in MuSCs. Tob1 ablation in mice accelerates MuSC population expansion and boosts muscle regeneration. Moreover, inactivation of Tob1 in MuSCs ameliorates the efficiency of MuSC transplantation in a murine muscular dystrophy model. Collectively, selective targeting of Tob1 might be a therapeutic option for the treatment of muscular diseases, including muscular dystrophy and age-related sarcopenia.
Evolving Economics: The Erosion of Medicare Reimbursement in Breast Surgery (2003–2023)
Authors: Gao Terry P. , HoSang Kristen M. , Bleicher Richard J. , Kuo Lindsay E. , Williams Austin D. 
Published: July 2024

Abstract
Introduction
Medicare significantly influences reimbursement rates, setting a standard that impacts private insurance policies. Despite declining rates in various specialties, the magnitude of these trends has not been examined in breast surgery. This study examines Medicare reimbursement trends for breast surgery operations.

Methods
Data for 10 breast operations from 2003 to 2023 were collected from the Medicare Physician Fee Look-Up Tool and yearly reimbursement was computed using the conversion factor. The year-to-year percentage change in reimbursement was calculated, and the overall median change was compared with the consumer price index (CPI) for inflation evaluation. All data were adjusted to 2023 United States dollars. The compound annual growth rate (CAGR) was calculated using inflation-adjusted data.

Results
Over the study period, reimbursement for the 10 breast operations had a mean unadjusted percentage increase of + 25.17%, while the CPI increased by 69.15% (p < 0.001). However, after adjustment, overall reimbursement decreased by − 20.70%. Only two operations (lumpectomy and simple mastectomy) saw increased inflation-adjusted Medicare reimbursement (+ 0.37% and + 3.58%, respectively). The CAGR was − 1.54% overall but remained positive for the same two operations (+ 0.02% and + 0.18%, respectively). Based on these findings, breast surgeons were estimated to be reimbursed $107,605,444 less in 2023 than if rates had kept pace with inflation over the past decade.

Conclusion
Inflation-adjusted Medicare reimbursement rates for breast surgeries have declined from 2003 to 2023. This downward trend may strain resources, potentially leading to compromises in care quality. Surgeons, administrators, and policymakers must take proactive measures to address these issues and ensure the ongoing accessibility and quality of breast surgery.
Zoonotic Sporotrichosis outbreak: Emerging public health threat in the Amazon State, Brazil
Authors: Mesquita Viviany Araujo , Talhari Sinesio , Leturiondo André Luiz , de Souza Guilherme Caldas , de Brito Euzenio Moreira , de Andrade Suanni Lemos , Fernandes Débora Cristina de Lima , Frota Maria Zeli Moreira , Cruz Rossilene Conceição da Silva , Guimarães Juliana de Andrade Rebouças , Miot Helio Amante , Talhari Carolina , Pedrosa Valderiza Lourenço 
Published: July 2024

Background
Sporotrichosis is the most common subcutaneous mycosis caused by Sporothrix spp. Traditionally, it is transmitted through injuries involving plant debris. However, over the past few decades, there has been an epidemic increase in human cases resulting from contact with infected animals, particularly cats, in various regions of Brazil. In this report, we report a notable increase in both human and animal cases within the Brazilian Amazon state.

Methodology/Principal findings
An ecological study was conducted by analyzing official records of human and animal sporotrichosis diagnosed in the state of Amazon from 2020 to 2023. Data including patient demographics, clinical manifestations, mycological examination results, and species identification through PCR confirmation were evaluated. During this period, a total of 950 human cases and 2,823 animal cases of sporotrichosis were reported at an exponential rate, since no human cases were registered in 2020. The spatial and temporal dispersion of human sporotrichosis followed that of animal cases, moving from downtown areas to the periphery. Contact with infected animals was reported in 77.7% of cases, with cats being the most commonly implicated (73.5%). Only 66.7% of individuals underwent mycological examination. Among the positive cultures for Sporothrix spp., 65.4% were identified as S. brasiliensis. All patients were treated with systemic antifungals.

Conclusions/Significance
This study highlights a rising incidence of sporotrichosis among animals and humans in the Brazilian Amazon region over the past four years, with S. brasiliensis being the predominant agent. Collaborative efforts involving healthcare professionals, veterinarians, and public health authorities are crucial to implement effective control measures, educate populations at risk, and promote responsible guidance for pet guardians. These measures are essential to mitigate the burden of epidemic sporotrichosis in Brazil.
Unveiling Multiple Myeloma: Actively Bleeding Extramedullary Gastric Myelomas Lead to Diagnosis
Authors: Shepherd Katherine , Obeng George , Randall Cara , Kolodney Joanna , Willard Megan 
Published: July 2024

ABSTRACT
Multiple myeloma (MM) is a disease of plasma cell replication, leading to a disruption of hematopoiesis, which commonly presents clinically with anemia and fatigue. Extramedullary myelomas are plasma cell collections in bone or soft tissue associated with MM and most often occur later in the disease process. We present a case of a patient with symptomatic anemia with actively bleeding gastric nodules, which were later found to be extramedullary gastric myelomas when pathology demonstrated kappa-restricted plasma cell neoplasms. To confirm the overall diagnosis, a bone marrow biopsy verified the patient had MM.
Effect of electron temperature and concentration on production of hydroxyl radical and nitric oxide in atmospheric pressure low-temperature helium plasma jet: Swarm analysis and global model investigation
Authors: Mladenović Željko , Gocić Saša 
Published: July 2024

Abstract
This work presents a numerical analysis by zero-dimensional global model of the influence of electron temperature and concentration on production of OH and NO for helium plasma jet propagating in the atmosphere of humid air. The calculations are done for the constant electron temperatures (1–4 eV) and concentrations (1010 cm−3 to 1014 cm−3). The mole fractions of air and water vapor vary from 100 to 10,000 ppm. The presented analysis reveals that at low electron temperature and H2O contents, the dissociative electron attachment to O2 dominates over attachment to H2O in production of OH. At higher amount, H2O modifies the high-energy tail of electron distribution function and increases rate coefficients for electron impact processes. Dissociative electron attachment to H2O dominates in the production of OH at 1 eV and remains important at higher energies when processes with O(1D), O(1S), O2(1∆) produce OH. Impact dissociation of H2O dominates over the dissociative attachment at 3 and 4 eV. NO comes mainly from air effluent in the plasma and O + NO2 at 100 ppm of H2O. Above 2 eV, the conversion process between OH and NO dominates in NO production at higher amount of H2O. Regarding dependencies on electron concentration, at low electron temperatures, electron distribution function is affected only at 1014 cm−3. But in the case of higher temperature, electron concentration and water vapor have negligible influence. The best agreement with measured data is obtained for electron concentration 1010 cm−3 and at temperature of 2 eV for OH and 1012 cm−3 and 3 eV for NO.
A new benchmark for camouflaged object detection: RGB-D camouflaged object detection dataset
Authors: Zhang Dongdong , Wang Chunping , Fu Qiang 
Published: July 2024

Abstract
This article aims to provide a novel image paradigm for camouflaged object detection, i.e., RGB-D images. To promote the development of camouflaged object detection tasks based on RGB-D images, we construct an RGB-D camouflaged object detection dataset, dubbed CODD. This dataset is obtained by converting the existing salient object detection RGB-D datasets by image-to-image translation techniques, which is comparable to the current widely used camouflaged object detection dataset in terms of diversity and complexity. In particular, in order to obtain high-quality translated images, we design a selection strategy that takes into account the structural similarity between pre- and post-conversion images, the similarity between the appearance of objects and their surroundings, as well as the ambiguity of object boundaries. In addition, we extensively evaluate the CODD dataset using existing RGB-D-based salient object detection methods to validate the challenge and usability of the dataset. The CODD dataset will be available at: https://github.com/zcc0616/CODD-Dateset.git.
Practical steps to develop a transcriptomic test for blood doping
Authors: Sutehall Shaun , Malinsky Fernanda , Voss Sven , Chester Neil , Xu Xiao , Pitsiladis Yannis 
Published: July 2024

Abstract
Blood doping remains a significant problem that threatens the integrity of sport. The current indirect method for detecting blood doping involves the longitudinal measurement of an athlete’s haematological variables and identification of suspicious results that are indicative of doping (i.e., the athlete biological passport). While this has played a significant role in the protection of clean sport, improvements are needed. The development of a transcriptomic test, that can be used to detect the use of blood doping has been discussed and researched for decades and yet, an anti-doping test that can be adopted by the World Anti-Doping Agency (WADA) is yet to be established. With recent advancements in our understanding, as well as in methods of sample collection, the possibility of a transcriptomic test that can be used by WADA, is imminent. There are, however, several practical considerations that must first be made, that will be highlighted in this perspective article.
Pengembangan Alat Ukur Skala Feeling Of Missing Out Pada Mahasiswa
Authors: Lestari Bella Dwi , Rasyid Mohammad Jamil Jiddan , Mudayanah Allyka Alderajat , Putri Devita Septiani , Aisyah Delia Putri , Fitriyani Eka 
Published: July 2024

Feeling of Missing Out adalah perasaan takut tertinggal karena tidak mengetahui aktivitas tertentu. Kemajuan internet menjadikan informasi tersebar dimana-mana, sehingga mudah bagi individu untuk mengetahui aktivitas orang lain misalnya melalui media sosial. Tujuan dari penelitian ini adalah mengembangkan alat ukur yang valid dan reliabel untuk mengetahui tingkat feeling of missing out (FOMO) pada mahasiswa. Ada banyak penelitian yang bertujuan untuk menentukan tingkat FOMO pada mahasiswa. Namun, skala baru diperlukan karena skala yang digunakan pada penelitian ini adalah versi adaptasi. Ada 20 item yang yang diberikan kepada 216 mahasiswa aktif yang berkuliah di Bandung. Metode yang digunakan pada penelitian ini yaitu metode kuantitatif dan literatur bacaan. Sampel pada penelitian yang didapat menggunakan metode non probably sampling dengan teknik purposive sampling. Hasil penelitian ini diperoleh 15 item yang menjadi item final dengan model penskalaan Likert, dilengkapi dengan analisis SPSS dan juga Structural Equation Model (SEM) dengan SmartPLS 4. Skala feeling of missing out menunjukkan nilai validitas dan reliabilitas yang cukup baik yaitu 0,309 dan 0,854. Sehingga didapatkan pengembangan alat ukur yang cukup valid dan reliabel dalam mengukur feeling of missing out pada mahasiswa.
Katarzyna Drąg, Lwowskie korzenie polskiego dziennikarstwa. Studia nad profesjonalizacją zawodu na przełomie wieków (1848–1914), Wydawnictwo Petrus, Kraków 2021, 512 ss.
Authors: Lakomy Mirosław 
Published: July 2024

Monografia autorstwa Katarzyny Drąg, wypełnia lukę jaka zaistniała w tematyce dotyczącej znakomitego ośrodka intelektualnego i kulturowego I i II Rzeczpospolitej we Lwowie. Istniał on i funkcjonował dynamicznie, mimo utraty niepodległości przez państwo polskie. Krótki okres suwerenności w międzywojniu, pobudził ośrodek lwowski, który zaowocował szeregiem osiągnięć na skalę światową. Jednakże rozwijające się i rywalizujące w tym czasie w Europie dwa ośrodki ideologii totalitarnych (nazistowskiej i komunistycznej), doprowadziły do wybuchu II wojny światowej, której ofiarą stał się także – a może nawet szczególnie - Lwów. Autorka z dużą swadą i ogromną wiedzą dotyka tego tematu w sposób profesjonalny. Książka niezwykle cenna dla medioznawców ale także politologów.
Basic oxygen furnace (BOF) slag as an additive in sodium carbonate-activated slag cements
Authors: Stefanini Laura , Walkley Brant , Provis John L. 
Published: July 2024

AbstractBasic oxygen furnace slag (BOFS) is a high-volume waste resulting from the production of steel from pig iron. Due to its high free lime content, BOFS is difficult to recycle and/or include into conventional cement systems. Alkali-activation technology offers a pathway to transform industrial wastes such as BOFS into low-carbon cements. Alternative precursors for cement systems are needed as the reliance on commonly used materials like ground granulated blast furnace slag (GGBFS) is becoming unsustainable due to decreasing availability. This study investigates alkali-activated cements incorporating 20 and 30 wt.% of naturally weathered BOFS as a replacement for GGBFS, in both sodium silicate- and sodium carbonate-activated systems. A fraction of BOFS subject to mechanical activation is compared against the untreated BOFS in the 20 wt.% systems. It is observed that in naturally weathered BOFS, a significant portion of the free-lime is found to convert to portlandite, which accelerates alkali-activation kinetics. In sodium silicate-activated systems, the high pH of the activator results in incomplete reaction of the portlandite present in BOFS. The sodium carbonate-activated system shows near complete conversion of portlandite, causing an acceleration in the kinetics of reaction, setting, and hardening. These findings confirm the viability of sodium carbonate activated GGBFS-based systems with only a minor loss in strength properties. BOFS can be utilised as a valuable cement additive for the production of sustainable alkali-activated cements utilising sodium carbonate as a less carbon-intensive activator solution than the more commonly used sodium silicate. Mechanical activation of BOFS offers further optimisation potential for alkali-activation.
Recent Expansion of the Cascades Volcano Observatory Geophysical Network at Mount Rainier for Improved Volcano and Lahar Monitoring
Authors: Kramer Rebecca L. , Thelen Weston A. , Iezzi Alexandra M. , Moran Seth C. , Pauk Benjamin A. 
Published: July 2024

Abstract
The U.S. Geological Survey Cascades Volcano Observatory (CVO) recently expanded its continuous geophysical monitoring at Mount Rainier, an active stratovolcano in Washington state. CVO monitors volcanoes in Oregon, Washington, and Idaho to characterize volcanic systems and detect unrest. Mount Rainier has a history of large lahar occurrences in the Holocene, including at least one that may not have been associated with volcanic activity. Pierce County, Washington, is one of the areas most at risk from large lahars. In the 1990s, CVO collaborated with Pierce County to install the Rainier lahar detection system (RLDS), an automated system designed to detect large lahars in high-risk drainages and mitigate hazards to heavily populated areas. The system was designed to detect lahars within 5–10 min of their occurrence and alert authorities of the need to evacuate populated low-lying areas before lahar arrival. In addition, CVO and the Pacific Northwest Seismic Network (PNSN) maintained and expanded a network of seismic and geodetic monitoring stations on and near the edifice to provide adequate volcano monitoring capabilities. Since 2016, CVO has worked to upgrade the existing RLDS and to expand its capabilities into other drainages around Mount Rainier. This expansion includes installation of 25 new broadband seismic stations with many including infrasound along high-risk drainages, as well as support for equipment upgrades at existing PNSN and CVO volcano monitoring sites. All stations transmit continuous, near-real-time data with dramatically improved spatial coverage for volcano monitoring and lahar hazard mitigation compared to the previous system.