bluuebunny/crossref_metadata_2025_split huggingface dataset:
More than Intelligence: Distinct Cognitive/Behavioral Clusters Linked to Adaptive Dysfunction in Children
Authors: Papazoglou Aimilia , Jacobson Lisa A. , Zabel T. Andrew 
Published: January 2013

AbstractImpairments in adaptive functioning are frequently associated with intellectual disability (ID); however, adaptive dysfunction can be seen in many individuals with a variety of neurological conditions without ID. The extent to which other variables may be associated with adaptive dysfunction is unclear. In a mixed clinical sample of children (n = 348) consecutively referred for neuropsychological evaluation, the majority were rated as showing weak adaptive skills (ABAS-II, >1 SD below the mean; 71%), with a substantial proportion evidencing frank impairment (>2 SD below the mean, 45%). We examined patterns of scores on measures of intelligence (WISC-IV) and behavioral/affective dysregulation (BRIEF and BASC-2). Using hierarchical cluster analysis, a four cluster model yielded the most appropriate fit and adaptive functioning was subsequently examined across clusters. As expected, adaptive functioning was most intact in the cluster characterized by average IQ and minimal behavioral dysregulation. Other clusters were marked by adaptive dysfunction and distinguished by sub-average intellectual functioning and varying behavioral/emotional dysregulation. In contrast to traditional views associating low IQ with adaptive dysfunction, adaptive impairment was comparable between the cluster characterized by low intelligence and the cluster with average intelligence but significant behavioral dysregulation. These data suggest that adaptive functioning should be considered across various cognitive/behavioral conditions. (JINS, 2013, 19, 1–9)
The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation
Authors: Abusleme Loreto , Dupuy Amanda K , Dutzan Nicolás , Silva Nora , Burleson Joseph A , Strausbaugh Linda D , Gamonal Jorge , Diaz Patricia I 
Published: January 2013

Abstract
The goals of this study were to better understand the ecology of oral subgingival communities in health and periodontitis and elucidate the relationship between inflammation and the subgingival microbiome. Accordingly, we used 454-pyrosequencing of 16S rRNA gene libraries and quantitative PCR to characterize the subgingival microbiome of 22 subjects with chronic periodontitis. Each subject was sampled at two sites with similar periodontal destruction but differing in the presence of bleeding, a clinical indicator of increased inflammation. Communities in periodontitis were also compared with those from 10 healthy individuals. In periodontitis, presence of bleeding was not associated with different α-diversity or with a distinct microbiome, however, bleeding sites showed higher total bacterial load. In contrast, communities in health and periodontitis largely differed, with higher diversity and biomass in periodontitis. Shifts in community structure from health to periodontitis resembled ecological succession, with emergence of newly dominant taxa in periodontitis without replacement of primary health-associated species. That is, periodontitis communities had higher proportions of Spirochetes, Synergistetes, Firmicutes and Chloroflexi, among other taxa, while the proportions of Actinobacteria, particularly Actinomyces, were higher in health. Total Actinomyces load, however, remained constant from health to periodontitis. Moreover, an association existed between biomass and community structure in periodontitis, with the proportion of specific taxa correlating with bacterial load. Our study provides a global-scale framework for the ecological events in subgingival communities that underline the development of periodontitis. The association, in periodontitis, between inflammation, community biomass and community structure and their role in disease progression warrant further investigation.
Autism Spectrum Disorders: Experience, Training, and Confidence Levels of School-Based Speech-Language Pathologists
Authors: Plumb Allison M. , Plexico Laura W. 
Published: January 2013

Purpose
To investigate the graduate training experiences of school-based speech-language pathologists (SLPs) working with children with autism spectrum disorders (ASDs). Comparisons were made between recent graduates (post 2006) and pre-2006 graduates to determine if differences existed in their academic and clinical experiences or their confidence in working with children with ASDs.

Method
A 46-item, web-based, national survey was used. Participants were recruited through e-mail and listservs for American Speech-Language-Hearing Association Special Interest Divisions 1 (Language, Learning, and Education) and 16 (School-Based Issues).

Results
Recent graduates reported a greater amount of graduate coursework relating to ASDs than pre-2006 graduates. However, the pre-2006 graduates reported significantly greater confidence in the areas of counseling parents of children who exhibit “red flags” of ASDs and addressing social communication, literacy, and academics in intervention.

Conclusion
Results of the current survey indicated an increase in the amount of preprofessional training that SLPs receive relating to ASDs. Nonetheless, the majority of SLPs reported that they could have benefitted from additional clinical experience and training working with children with ASDs. The greater degree of confidence reported by the pre-2006 graduates highlights the importance of experience and continuing education for professionals in the field of speech-language pathology.
BETAWARE: a machine-learning tool to detect and predict transmembrane beta-barrel proteins in prokaryotes
Authors: Savojardo Castrense , Fariselli Piero , Casadio Rita 
Published: January 2013

Abstract
Summary: The annotation of membrane proteins in proteomes is an important problem of Computational Biology, especially after the development of high-throughput techniques that allow fast and efficient genome sequencing. Among membrane proteins, transmembrane β-barrels (TMBBs) are poorly represented in the database of protein structures (PDB) and difficult to identify with experimental approaches. They are, however, extremely important, playing key roles in several cell functions and bacterial pathogenicity. TMBBs are included in the lipid bilayer with a β-barrel structure and are presently found in the outer membranes of Gram-negative bacteria, mitochondria and chloroplasts. Recently, we developed two top-performing methods based on machine-learning approaches to tackle both the detection of TMBBs in sets of proteins and the prediction of their topology. Here, we present our BETAWARE program that includes both approaches and can run as a standalone program on a linux-based computer to easily address in-home massive protein annotation or filtering.
Availability and implementation: http://www.biocomp.unibo.it/∼savojard/betawarecl
Contact: piero.fariselli@unibo.it
Supplementary information: Supplementary data are available at Bioinformatics online.
First Report of Damping-off Caused by Pythium aphanidermatum on Leaf Beet (Beta vulgaris subsp. vulgaris) in Italy
Authors: Garibaldi A. , Gilardi G. , Ortu G. , Gullino M. L. 
Published: January 2013

During July 2010, symptoms of crown and root rot were observed on leaf beet (Beta vulgaris L. subsp. vulgaris) grown in a commercial field near Torino (northern Italy). The first symptoms developed 25 days after sowing with temperatures ranging from 25 to 30°C, and 20% of plants were affected. Affected plants were stunted and leaves showed chlorosis and suddenly wilted. The collar and young stems were affected first and appeared brown, water-soaked, and were characterized by a soft rot. Eventually, all affected plants collapsed. Thin aerial mycelia were visible on the surface of the infected plants if maintained at a high relative humidity. Tissue fragments of 1 mm2 were excised from the margins of the lesions, dipped in a solution containing 1% sodium hypochlorite, and plated on potato dextrose agar (PDA) and on a medium selective for oomycetes (2). Plates were incubated under constant fluorescent light at 22 ± 1°C for 5 days. Five isolates, grown on V8 medium (vegetable mix 300 g; agar 15 g; CaCO3 1.5 g; distilled water 1 liter) and observed under light microscope showed the morphological characters of Pythium aphanidermatum (3). This result was confirmed by PCR and sequence analysis. The internal transcribed spacer (ITS) region of rDNA of a single isolate (Py 7/10) was amplified using the primers ITS1/ITS4 and sequenced. BLAST analysis (1) of the 815 bp segment showed a 99% homology with the sequence of P. aphanidermatum (GenBank Accession JN695786). The nucleotide sequence has been assigned to the GenBank Accession JX462954. Pathogenicity tests were performed twice on B. vulgaris subsp. vulgaris grown in 2-liter pots, containing a steam disinfested organic peat substrate (70% black peat, 30% white peat, pH 5.5 to 6, N 110 to 190 mg L–1, P2O5 140 to 230 mg L–1, K2O 170 to 280 mg L–1), infested with wheat and hemp kernels colonized with a strain of P. aphanidermatum at a rate of 1 g L–1. Ten seeds per pot were sown in four pots filled with the infested medium, while the same number of seeds were sown in non-infested substrate. Plants were kept in two growth chambers, at 20 and 27°C. The first symptoms developed 7 days after the artificial inoculation. After 20 days, 70% of plants were infected at 27°C, while 10% were affected at 20°C. Control plants remained healthy at both temperatures. P. aphanidermatum was consistently reisolated from the lesions. To our knowledge, this is the first report of damping off of B. vulgaris subsp. vulgaris caused by P. aphanidermatum in Italy. The importance of the disease, at present limited, could increase in areas where leaf beet is intensively grown. References: (1) S. F. Altschul et al. Nucleic Acids Res. 25:3389, 1997. (2) H. Masago et al. Phytopathology 67:425, 1977. (3) T. Watanabe. Pictorial Atlas of Soil and Seed Fungi. CRC Press, Florida, 2002.
Lessons on RNA Silencing Mechanisms in Plants from Eukaryotic Argonaute Structures
Authors: Poulsen Christian , Vaucheret Hervé , Brodersen Peter 
Published: January 2013

Abstract
RNA silencing refers to a collection of gene regulatory mechanisms that use small RNAs for sequence specific repression. These mechanisms rely on ARGONAUTE (AGO) proteins that directly bind small RNAs and thereby constitute the central component of the RNA-induced silencing complex (RISC). AGO protein function has been probed extensively by mutational analyses, particularly in plants where large allelic series of several AGO proteins have been isolated. Structures of entire human and yeast AGO proteins have only very recently been obtained, and they allow more precise analyses of functional consequences of mutations obtained by forward genetics. To a large extent, these analyses support current models of regions of particular functional importance of AGO proteins. Interestingly, they also identify previously unrecognized parts of AGO proteins with profound structural and functional importance and provide the first hints at structural elements that have important functions specific to individual AGO family members. A particularly important outcome of the analysis concerns the evidence for existence of Gly-Trp (GW) repeat interactors of AGO proteins acting in the plant microRNA pathway. The parallel analysis of AGO structures and plant AGO mutations also suggests that such interactions with GW proteins may be a determinant of whether an endonucleolytically competent RISC is formed.
Knowledge, documentation and a London location
Authors: Bawden David 
Published: January 2013

PurposeAs documents, and the whole information and communication environment, become increasingly digital, it is natural to assume that physical location becomes of less importance. The aim of this paper is to highlight two newly published books, which remind us that this idea should be examined with a critical eye.Design/methodology/approachThis editorial takes the form of a literature review and a viewpoint.FindingsThe paper finds books of this kind remind us that a physical place, a locality, has sometimes been a very powerful stimulus to the development of collections, of memory institutions, and of the advances in education and dissemination of knowledge which are associated with them. This is worth remembering as we move into a digital information world.Originality/valueThe paper offers the author's viewpoint as well as highlighting these two books which join a small number which have analysed and celebrated the history of intellectual advances in London.
“Sustainable management” of commercial electronic research resources and of its use in bibliometrics
Authors: Regolini Amanda , Gentilini Emilie , Baligand Marie‐Pascale , Jannès‐Ober Emmanuelle 
Published: January 2013

PurposeThis paper aims to analyze the pertinence of Bradford's law applied to a set of electronic periodical collections in a given discipline.Design/methodology/approachThis study applied Bradford's law using citations rather than articles from a theme, thus ensuring the pertinence of the periodicals cited. Concentrating on citations in articles focuses on the stage following research rather than prior stages. The sources are actually used because they have been cited.FindingsThe study demonstrates the data centrality phenomenon based on the leading periodicals in a theme. There was a relationship between the electronic periodical collection and the number of citations in the relevant journals in a theme.Originality/valueAlthough today's use of periodical titles is defined first and foremost by readership statistics, a more detailed analysis on the qualitative aspect can be an additional benefit in the negotiations conducted on a macro scale. Using Bradford's law could be envisaged as a complementary tool for a sustainable management of commercial electronic resources.
Embedding innovation for scholarly information and research
Authors: Sparks JoAnne , O'Brien Linda , Richardson Joanna , Wolski Malcolm , Tadic Sanja , Morris Joanne 
Published: January 2013

PurposeThe purpose of this paper is to report on “turning a new page” (TNP), a business improvement initiative undertaken by Scholarly Information & Research (SIR). The aim is to embed innovation and integrate e‐research and library services. SIR is part of the Information Services (INS) division at Griffith University, one of the top research universities in Australia. SIR provides library services, publication support and eResearch services to over 43,000 students and staff at five campuses and online.Design/methodology/approachTNP combines methods from best practices around continuous improvement, change management and business planning to achieve better alignment operationally and to prioritise potential improvements to services. The focus is on services required in three to five years for the “new generation” of users who will need them.FindingsExisting services were unevenly delivered and resources unevenly distributed. A key initial step is restructuring to collocate similar capabilities and redistribute resources, and provides a framework for developing future capacity. The integrated staffing approach nurtures innovation and skills development.Originality/valueIntegrating e‐research services with library services to this extent has not been achieved in an Australian context before. The combination of methods applied and the progress achieved to date illustrates the value of the approach and may be relevant for other research‐intensive universities.
Embedding information literacy in an MA TESOL program
Authors: Soules Aline , Nielsen Sarah , Youn Lee Hee , Al Rifae Kinda 
Published: January 2013

PurposeThis case study aims to describe the collaborative process used to embed an information literacy curriculum into the MA Teaching of English to Speakers of Other Languages (TESOL) program at university.Design/methodology/approachThe study focuses on how this curriculum was conceived, implemented, and has evolved based on new ideas from the MA coordinator, the librarian, the students, and continuing review of the literature of librarianship and TESOL. The coordinator and librarian describe their approach to curriculum development and their analysis of curricular outcomes, and two graduates from the program describe the program's impact from the student perspective.FindingsThe paper finds that the MA TESOL coordinator and the librarian embedded information literacy through structured assignments, reflective essays, and librarian in‐person classroom visits. Ongoing assessment of student survey results and reflective essays provide impetus for ongoing changes to the curriculum. Students' perceptions about and practice of information literacy enrich their program experiences and improve their preparation for further academic work or subsequent TESOL teaching.Research limitations/implicationsMore follow up is needed with the three cohorts that have completed the MA program since the development of the embedded information literacy curriculum.Practical implicationsIn their own teaching, graduates emphasize information literacy to their students, further increasing the impact of this program.Social implicationsStudents develop a closer relationship with the librarian and think differently and more regularly about libraries and information literacy principles.Originality/valueThere is a growing body of library literature on embedded librarianship and language learning students, but none focusing exclusively on the role of information literacy in the preparation of teachers of language learning students.
Beyond eco‐efficiency: understanding CS through the IC practice lens
Authors: Wasiluk Kendra L. 
Published: January 2013

PurposeThe aim of this paper is to draw a conceptual bridge between the intellectual capital (IC) and corporate sustainability (CS) literature to investigate how firms mobilise their IC in order to implement sustainable development into their business practices.Design/methodology/approachA case study of the Australian property and construction sector was undertaken and the results are discussed.FindingsThe finding offered in this paper is that in order to progress beyond the efficiency phase of CS, firms need to shift from justifying the business case for sustainability, to understanding how to mobilise their IC to progress towards a more ecological sustainable and socially equitable enterprise. Ongoing evolution, with regard to the approach adopted for the management of IC, is also helping to drive organisational change towards more sustainable business models. Each category of IC plays a role with regard to operationalising CS into practice and supporting organisational change. The identified roles include motivating, supporting, implementing and performance.Research limitations/implicationsIn relation to the interview data collected it is generally limited to the views of the senior management and as such may not reflect the views of the employees of the organisation.Originality/valueThis paper adds to the conversation of the third stage of IC research, based on the proposition that the performative approach to IC can help move business beyond the eco‐efficiency stage of corporate sustainability and in doing so improves the relevance and usefulness of the IC concept for business organisations.
Robust project portfolio management: capability evolution and maturity
Authors: Killen Catherine P. , Hunt Robert A. 
Published: January 2013

PurposeThe purpose of this paper is to increase understanding of project portfolio management (PPM) capability evolution, in order to guide the implementation and ongoing development of robust capabilities.Design/methodology/approachThis research adopts a dynamic capabilities perspective and draws on organizational learning theory to investigate the path‐dependent nature of PPM implementation and development. It employs a multiple‐case study of six organizations.FindingsEach of the case organizations reported a high level of evolution and change within their PPM capabilities, both purposeful and unintended. Potential “fragilities” are identified, such as the emergence of a “success trap” that inhibits explorative innovation and difficulties in stopping poor projects to reallocate resources. Based on findings from the literature and the multiple‐case study, a capability maturity model is proposed to assist in the development of robust PPM capabilities that will continue to evolve and stay relevant in dynamic environments.Research limitations/implicationsThe research is based on six organizations and may not be representative of all environments. The proposed maturity model has only been used in initial trials to evaluate capability maturity, and its use in guiding capability development has not been studied. Further research is required to test and evolve the maturity model.Practical implicationsThe maturity model will be of interest to managers as a tool to analyze PPM maturity and identify areas for further development or to guide new PPM implementations.Originality/valueThe proposed maturity model extends existing maturity models by incorporating organizational learning capabilities, by recognizing antecedents for maturity stages that build upon other capabilities, and by including steps to recognize and avoid potential “fragilities” and to ensure robust PPM performance over time.
Association between inotrope treatment and 90‐day mortality in patients with septic shock
Authors: WILKMAN E. , KAUKONEN K.‐M. , PETTILÄ V. , KUITUNEN A. , VARPULA M. 
Published: January 2013

BackgroundAdministration of inotropes in septic patients with low cardiac output or low central/mixed venous saturation is recommended in current guidelines. However, the impact of inotrope use on the outcome of these patients is controversial. We aimed to analyse the association of inotrope treatment with 90‐day mortality.MethodsData from 420 consecutive patients with septic shock were retrospectively collected from the intensive care unit (ICU) data management system. Factors associated with inotrope treatment were assessed. The association of 90‐day mortality with inotrope treatment was first analysed using logistic regression analysis, and second including propensity score based on observed variables for selection to inotrope treatment. A subgroup analysis was performed for the 252 patients with pulmonary artery catheter.ResultsOne hundred eighty‐six (44.3%) patients received inotrope treatment during the first 24 h in ICU. Of those, 168 (90.3%) received dobutamine, 29 (15.6%) levosimendan, and 23 (12.4%) epinephrine. Blood lactate (P < 0.001), central venous pressure, (P < 0.001), and norepinephrine dose (P = 0.03) were independently associated with inotrope treatment. Patients with inotrope treatment had a higher 90‐day mortality (42.5% vs. 23.9%, P < 0.001). Age (P < 0.001), Acute Physiology and Chronic Health Evaluation II score (P < 0.001), and inotrope treatment (P = 0.003) were independently associated with 90‐day mortality also after adjustment with propensity score.ConclusionThe use of inotrope treatment in septic shock was associated with increased 90‐day mortality without and after adjustment with propensity to receive inotrope. To differentiate between non‐observed biases of severity of septic shock and an unfavourable effect of inotropes, prospective studies are needed.