bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standardized approach to the conservative surgery of hepatic cystic echinococcosis: A prospective study
Authors: Trigui Aymen , Fendri Sami , Saumtally Mohammad Saad , Akrout Amira , Trabelsi Jihen , Daoud Rahma , Toumi Nozha , Ketata Salma , Boujelbene Wael , Mzali Rafik , Dziri Chadli , Ben Amar Mohamed , Boujelben Salah 
Published: June 2024

Objective
Surgery is the mainstay of hepatic cystic echinococcosis (HCE). The conservative surgery of HCE carries a non-negligible risk of recurrence and significant morbidity, dominated by Deep Surgical Site Infections (DSSI). To address these issues, we have improved and standardized this technique, which could reduce complications and achieve better postoperative outcomes.

Patients and methods
We conducted a prospective study from June 2017 to June 2022 involving of patient operated using a standardized open technique for uncomplicated HCE at Habib Bourguiba University Hospital, Sfax, Tunisia. The aim was to obtain results at least similar to radical management in terms of DSSI. Patients with large cystobiliary fistulas or patients with complicated cysts were excluded.

Results
Fifty patients with 106 cysts were operated using the standardized technique comprising of liver mobilization, intraoperative ultrasound, systematic methylene blue injection to detect cystobiliary fistulas and omentoplasty. The median age of the patients was 44(semi-interquartile range: 16) years. The main symptom described by the patient was pain in 43 cases (86%). An abnormal liver test was found in 20 cases (40%). On imaging studies, the cyst had a median size of 7.4(3.0) cm. Cyst of the hepatic dome accounted for 38 cases (35.8%) with most cysts being situated in the right hemi-liver. Visual inspection of the cavity and Methylene blue testing allowed for the discovery of 57 cysts (53.7%) that had cystobiliary fistulas that were sutured. Omentoplasty was performed in 77 cysts (72.6%). Postoperatively, only 2 cases (1.9%) developed a DSSI in the form of an external bile leak with resolved with conservative management. No case of recurrence was found after a median follow-up of 24 months.

Conclusion
The standardized conservative surgical technique, in selected patients, shows promise in reducing DSSI rates and overall morbidity, and achieve as equally good result as radical management.
Bridging the gap: Navigating the impact of dietary supplements on abdominal aortic aneurysm progression- A systematic review
Authors: Amirsardari Zahra , Khalili Asal , Behnoush Amir hossein , Agahi Sadaf , Amirsardari Fatemeh , Kohansal Erfan , Sadeghipour Parham 
Published: June 2024

BackgroundVitamins D, E, A, B, C, and Omega-3 play crucial roles in modulating inflammatory and oxidative stress pathways, both implicated in abdominal aortic aneurysm (AAA) development. Recent research has explored the potential impact of dietary supplements on AAA progression. The systematic review aims to assess interventional studies investigating the effects of various dietary supplements on the development and severity of abdominal aortic aneurysms.MethodA systematic search using relevant keywords related to abdominal aortic aneurysm and dietary supplements was conducted across four databases (PubMed, Embase, Scopus, and Web of Science). Quality assessment for animal studies employed SYRCLE and the Cochrane Collaboration Risk of Bias Tool for randomized control trials. The study protocol is registered in PROSPERO under the registry code CRD42023455958.ResultsSupplementation with Omega-3, Vitamins A, C, D, E, and the Vitamin B family exhibited positive effects in AAA progression. These supplements contributed to a reduction in AAA diameter, elastin degradation, inflammatory responses, and reactive oxygen species. Additional supplements such as Zinc, methionine, and phytoestrogen also played roles in mitigating AAA progression.ConclusionThe findings of this study underscore the potential role of dietary supplements in the progression of AAA. Predominantly based on animal studies, the results indicate that these supplements can limit AAA progression, primarily evidenced by their ability to mitigate inflammatory processes and oxidative stress pathways.
Exploring the role of interleukin-1β and interleukin-6 in the pathophysiology of obsessive-compulsive disorder
Authors: Sarmin Nisat , Roknuzzaman A. S. M. , Sarker Rapty , Rashid Mamun-or- , Hasan Ahasanul , Qusar M. M. A. Shalahuddin , Kabir Eva Rahman , Islam Md. Rabiul , Mahmud Zobaer Al 
Published: June 2024

Background
Obsessive-compulsive disorder (OCD) is a highly prevalent neuropsychiatric disorder. Recently, there has been a growing interest in investigating the association between pro-inflammatory cytokines and the pathogenesis of OCD. However, studies targeting interleukin-1β (IL-1β) and interleukin-6 (IL-6) in OCD are limited. Therefore, the present study aimed to explore the potential role of pro-inflammatory cytokines IL-1β and IL-6 in the pathophysiology and development of OCD.

Methods
This study recruited 58 OCD patients and 30 age-sex-matched healthy controls (HCs). A qualified psychiatrist diagnosed OCD patients and assessed HCs based on the Diagnostic and Statistical Manual for Mental Health Disorders, 5th edition (DSM-5) criteria. We measured the severity of OCD using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). Serum IL-1β and IL-6 levels were measured using ELISA kits following the appropriate methods.

Results
The results showed that serum IL-1β levels were significantly elevated in OCD patients compared to HCs (23.68±1.65 pg/ml vs. 15.75±1.02 pg/ml; p = 0.002). Similarly, OCD patients exhibited significantly higher serum IL-6 levels than HCs (44.97±0.73 pg/ml vs. 37.04±0.35 pg/ml; p<0.001). We observed both cytokines were positively correlated with the Y-BOCS scores in OCD patients (IL-1β: r = 0.380, p = 0.015; IL-6: r = 0.324, p = 0.026) which indicates their role in disease pathophysiology.

Conclusion
These results suggest that serum IL-1β and IL-6 levels may be associated with the pathophysiology of OCD. Also, these cytokines levels in blood samples can serve as early risk assessment tools for the development of OCD. We recommend further studies in a large and homogeneous population to support these findings.
Age-related experiences of diverse older women living with HIV: A scoping review protocol informed by intersectionality
Authors: Kokorelias Kristina , Brown Paige , Walmsley Sharon , Zhabokritsky Alice , Su Esther , Sirisegaram Luxey 
Published: June 2024

IntroductionOlder women living with HIV often go unnoticed due to societal biases and stigmas. Despite a rise in cases among older women, there is limited research on the psychosocial factors impacting their experiences. Aging complexities compounded by HIV and menopause affect these women’s health, while factors like mental health impact, changing support networks, and ageism with HIV stigma influence their well-being. Existing studies mostly compare older HIV-positive individuals without considering gender and intersectional identities, limiting understanding of their unique experiences. The scarcity of research addressing age-related differences from diverse perspectives delays the development of tailored treatments and interventions.ObjectivesThe study aims to comprehensively explore the age-related experiences of older women with HIV through three sub-questions that address (1) Key experiences, medical and social challenges, and strengths; (2) Impact of intersectional identities on their experiences; and (3) Gaps and limitations in current research.MethodsUtilizing a scoping review approach, the study seeks to map existing literature, employing a theoretical framework rooted in Sex- and Gender-Based Analysis Plus (SGBA+). Articles focusing on the age-related experiences of older women living with HIV aged 50 and above will be included. The study selection process will involve two independent reviewers screening articles based on pre-established inclusion criteria. Data extraction and synthesis will follow, analyzing the influence of sex, gender, and other identities on experiences.DiscussionThe study’s comprehensive approach aims to bridge gaps in understanding older women’s HIV experiences, emphasizing intersectionality. While limited to English-language peer-reviewed articles, this review seeks to offer valuable insights for healthcare, policy, and research, potentially fostering positive change in the lives of diverse older women living with HIV.
Fecal and Serum Granulocyte Protein Levels in Inflammatory Bowel Disease and Irritable Bowel Syndrome and Their Relation to Disease Activity
Authors: Ekoff Helena , Rydell Niclas , Hellström Per M. , Movérare Robert 
Published: June 2024

INTRODUCTION:
Neutrophilic calprotectin (CP) and myeloperoxidase (MPO), neutrophil gelatinase-associated lipocalin (NGAL), and eosinophil-derived neurotoxin (EDN) are suggested proxy markers for gut inflammation. However, there are insufficient supporting data for MPO, NGAL, and EDN.

METHODS:
In a cross-sectional investigation including adult patients, we studied the ability of CP, MPO, NGAL, and EDN, measured in fecal and serum samples, to differentiate between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS), and to predict disease activity.

RESULTS:
Fifty-nine patients had ulcerative colitis (UC), 38 had Crohn's disease, and 100 patients had IBS. The protein concentrations were higher in patients with IBD in the fecal samples (P < 0.001) and the serum samples (P < 0.01), and they correlated weakly (rs ≤0.38) between the sample sources. Fecal EDN was higher in patients with Crohn's disease compared with UC (1.79 vs 0.50 mg/kg, P = 0.016). The neutrophilic proteins were superior to EDN in the fecal samples for differentiating between patients with IBD and IBS. Fecal MPO (cutoff: 0.86 mg/kg) had the highest sensitivity (74.7%) and specificity (84.6%). Combining fecal CP and MPO increased the sensitivity to 82.3% (specificity: 73.6%). NGAL (cutoff: 196.9 μg/L) showed the best discriminating performance in serum (sensitivity: 62.9%; specificity: 68.0%). Serum NGAL (cutoff: 272.4 μg/L) predicted active disease in UC (Partial Mayo Score ≥2) with a sensitivity and specificity of 57.1% and 83.3%, respectively.

DISCUSSION:
Fecal MPO and serum NGAL are promising novel biomarkers, in addition to fecal CP, for differentiating between IBD and IBS. Serum NGAL may also predict disease activity in patients with UC.
Concentration of immunoglobulin free light chains in cerebrospinal fluid in the diagnosis of multiple sclerosis
Authors: Nabiev Sh. R. , Dzhukkaeva S. A. , Asvedov M. Sh. , Prokhorov D. E. , Popova E. V. , Grinyuk V. V. , Magomadova P. R. , Apevalova A. R. , Voskresenskaya O. N. 
Published: June 2024

Objective: to determine the sensitivity and specificity of method of determining the concentration of immunoglobulin free light chains (FLCs) in cerebrospinal fluid (CSF) in the diagnosis and differential diagnosis of multiple sclerosis (MS).Material and methods. 80 patients participated in the study. The main group consisted of 54 patients diagnosed with MS according to the 2017 McDonald criteria. The comparison group (n=26) comprised patients with other diseases of the nervous system. An enzyme-linked immunosorbent assay (ELISA) was used to determine the concentration of FLCs (kappa- and lambda-chains) in the CSF.Results. In the group of patients with MS, an increase in the concentration of free kappa-chains (к-FLCs) in the CSF was found compared to the comparison group (p<0.001). With an increase in the concentration of κ-FLCs, a decrease in the sensitivity and an increase in the specificity of the method for the diagnosis of MS was observed. The к-FLCs cut-off value of 0.17 μg/ml had a sensitivity of 68.5 % and a specificity of 92.3 %. The cut-off value of 0.22 μg/ml had a sensitivity of 59.3 % and a specificity of 100 %. The concentrations of lambda-FLCs in the CSF in the MS group and in the comparison, group did not differ significantly (p=0.1).Conclusion. The results obtained indicate an increase in the concentration of к-FLCs in the CSF of MS patients. This biomarker showed a high specificity for this pathology. However, further development of optimal thresholds is required to clarify the diagnostic value of CSF к-FLCs concentration in MS patients.
Horários de administração de corticosteroides
Authors: Azevedo Maria Fernanda Salomão de 
Published: June 2024

Em nosso organismo, há um hormônio chamado cortisol, que é o responsável por manter a pressão arterial e nos dar energia. É liberado no sangue mais intensamente pela manhã, e no decorrer do dia essa liberação diminui.Os medicamentos glicocorticoides imitam o efeito do cortisol, por isso, o melhor horário para tomá-los é pela manhã, para interferir menos na liberação natural do cortisol pelo nosso organismo e, com isso, diminuir a possibilidade de certos efeitos indesejados. Além do horário de administração, a dose utilizada e a duração do tratamento também influenciam no risco de ocorrência desses efeitos. Se esquecer de usar o medicamento e ainda for de manhã, tome imediatamente a dose esquecida. Se lembrar no período da tarde ou da noite, não volte a utilizá-lo e tome normalmente no próximo horário.
Auf dem Weg vom Teenager zum Twen
Authors: Kühn Diemar , Plewa Hans-Erich 
Published: June 2024

Regionalstatistische Informationssysteme sind aus dem Arbeitsalltag der statistischen Landesämter nicht mehr wegzudenken: Sie sind gleichrangig neben die klassischen Formen der Bereitstellung statistischer Informationen getreten. Die Vielzahl statistischer Ämter hat indessen auch zu einer Vielzahl verschiedener Lösungen gefunden. Welchen Weg die Informationssysteme bisher gingen, wo sie heute stehen und welchen Weg sie künftig einschlagen sollten – diese Fragen werden im Überblick untersucht. Am Beispiel der Landesdatenbank Nordrhein-Westfalen wird sodann das Leistungsvermögen eines relativ fortgeschrittenen statistischen Informationssystems dargestellt.
Renin–angiotensin system inhibitors positively impact on multiple aging regulatory pathways: Could they be used to protect against human aging?
Authors: de Cavanagh Elena M. V. , Inserra Felipe , Ferder León 
Published: June 2024

AbstractThe renin–angiotensin system (RAS)—a classical blood pressure regulator—largely contributes to healthy organ development and function. Besides, RAS activation promotes age‐related changes and age‐associated diseases, which are attenuated/abolished by RAS‐blockade in several mammalian species. RAS‐blockers also increase rodent lifespan. In previous work, we discussed how RAS‐blockade downregulates mTOR and growth hormone/IGF‐1 signaling, and stimulates AMPK activity (together with klotho, sirtuin, and vitamin D‐receptor upregulation), and proposed that at least some of RAS‐blockade's aging benefits are mediated through regulation of these intermediaries and their signaling to mitochondria. Here, we included RAS‐blockade's impact on other aging regulatory pathways, that is, TGF‐ß, NF‐kB, PI3K, MAPK, PKC, Notch, and Wnt, all of which affect mitochondria. No direct evidence is available on RAS/RAS‐blockade‐aging regulatory pathway–mitochondria interactions. However, existing results allow to conjecture that RAS‐blockers neutralize mitochondrial dysfunction by acting on the discussed pathways. The reviewed evidence led us to propose that the foundation is laid for conducting clinical trials aimed at testing whether angiotensin‐converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB)—even at subclinical doses—offer the possibility to live longer and in better health. As ACEi and ARB are low cost and well‐tolerated anti‐hypertension therapies in use for over 35 years, investigating their administration to attenuate/prevent aging effects seems simple to implement.
Kulturgutschutz und Bekämpfung von Desinformation – Aufgaben internationaler Bibliothekskooperation in Zeiten des Krieges
Authors: Bohn Anna , Hamann Olaf 
Published: June 2024

Zusammenfassung
Der Beitrag behandelt die internationale Zusammenarbeit der Bibliotheken zum Erhalt von Kulturgut im Netzwerk Kulturgutschutz Ukraine und die Bekämpfung von Desinformation in Zeiten des Russisch-Ukrainischen Kriegs. Der erste Abschnitt zeigt Russlands Einsatz von (Des-)Information als Waffe im Angriffskrieg, der von einem global geführten Informationskrieg flankiert wird. Der zweite Abschnitt klärt die Begriffe Desinformation, Misinformation, Fake News und Deep Fakes. Der dritte Abschnitt hebt die Bedeutung präziser Sprache und Wortwahl zur Vermeidung von Manipulation und Desinformation hervor. Der vierte Abschnitt präsentiert Strategien zur Bekämpfung von Desinformation. Der fünfte Abschnitt gibt Einblick in die Arbeit des Netzwerks Kulturgutschutz Ukraine und verdeutlicht die Bedeutung internationaler Hilfe für Bibliotheken und Gesellschaften, die unter Angriff stehen. Der sechste Abschnitt präsentiert ausgewählte Informationsdienstleistungen und Nachrichtenquellen aus der Ukraine, Deutschland sowie russische Exilmedien. Der siebte Abschnitt unterstreicht die Rolle der Informationseinrichtungen für den Zugang zu Dokumenten über den Krieg, sowie über Kriegsverbrechen und Menschenrechtsverletzungen vor dem Hintergrund der Informationsethik und Berufsethik von Bibliothekarinnen und Bibliothekaren.
Delayed diagnosis of new onset pediatric diabetes leading to diabetic ketoacidosis: a retrospective cohort study
Authors: Hadley Stephanie M. , Michelson Kenneth A. 
Published: June 2024

Abstract

Objectives
Patients with a delayed diagnosis of diabetes are more likely to present in diabetic ketoacidosis (DKA). The objective of this study was to assess the prevalence, risk factors, and consequences of missed pediatric diabetes diagnoses in emergency departments (EDs) potentially leading to DKA.

Methods
Cases of children under 19 years old with a first-time diagnosis of diabetes mellitus presenting to EDs in DKA were drawn from the Healthcare Cost and Utilization Project database. A total of 11,716 cases were included. A delayed diagnosis of diabetes leading to DKA was defined by an ED discharge in the 14 days prior to the DKA diagnosis. The delayed diagnosis cases were analyzed using multivariate analysis to identify risk factors associated with delay, with the primary exposure being child opportunity index (COI) and secondary exposure being race/ethnicity. Rates of complications were compared across groups.

Results
Delayed diagnosis of new onset diabetes leading to DKA occurred in 2.9 %. Delayed diagnosis was associated with COI, with 4.5 , 3.5, 1.9, and 1.5 % occurring by increasing COI quartile (p<0.001). Delays were also associated with younger age and non-Hispanic Black race. Patients with a delayed diagnosis were more likely to experience complications (4.4 vs. 2.2 %, p=0.01) including mechanical ventilation, as well as more frequent intensive care unit admissions and longer length of stays.

Conclusions
Among children with new-onset DKA, 2.9 % had a delayed diagnosis. Delays were associated with complications. Children living in areas with lower child opportunity and non-Hispanic Black children were at higher risk of delays.
Synthesis, characterization and film preparation of 6FDA-based polyimides with polar groups arranged for thermal crosslinking
Authors: López-Badillo Maribel , Galicia-Aguilar José Alberto , García-Castro Miguel Ángel , Varela-Caselis Jenaro Leocadio , Herrera-González Ana Maria , Reyes-Montero Armando , López-Morales Salvador 
Published: June 2024

Abstract
Thermal crosslinking of polyimides is a relevant methodology to increase their chemical resistance. This reaction is induced by heating after polymerization. Although this reaction is considered a viable route to modify polyimides, there is controversy over the specific temperature for the reaction. To contribute to the knowledge of crosslinked structures, we performed a differential scanning calorimetric (DSC) and solubility test studies on a series of polyimides with different molar ratios of carboxylic acid groups. With 3,5-diaminobenzoic acid (DABA) as a source of carboxylic acid groups, the copolyimides were synthesized from 2,2′-bis(3,4-dicarboxyphenyl)hexafluoropropane dianhydride (6FDA) and 4,4ʹ-hexafluoropropylidenebis(p-phenylenoxy)dianiline (6FPA) to form blocks of 6FDA:6FPA (n) and 6FDA:DABA (m) from m = 0–100 %. Flat films were prepared at 50 ± 3 µm with polyimides. In the thermogram of the flat films, a heat absorption zone associated with the decarboxylation reaction was identified with an endothermic minimum at 260 °C, which was assigned to the crosslinking temperature. Furthermore, heating time was varied for 3–36 h to determine the insolubility of the thermally crosslinked polyimide; from 24 h of heating the polyimide were insoluble. The polyimides were thoroughly characterized by ATR-FTIR, 1H NMR, TGA, SEM, the fractional free volume (FFV) was determined by the Bondi’s group contribution method and solubility to different organic solvents. The FFV of crosslinked polyimides increases relative to pristine polyimides by 2 % for those with higher DABA content and 40 % for those with lower DABA content. Finally, also the glass transition temperature increases in the crosslinked polyimides relative to the pristine ones from 280 °C for the lowest DABA content to 402 °C for the highest DABA content, demonstrating the increase in the thermal resistance of the structure.
The Marxist Method as the Foundation of Social Criticism – Lukács’ Perspective
Authors: Souza Mateus Soares de 
Published: June 2024

AbstractThe investigation into the foundations of social critique has increasingly gained importance in the tradition known as Critical Theory. In this context, I will analyze Lukács’ work, particularly History and Class Consciousness, to comprehend the foundation he provides for social critique, rooted in the adoption of Marxism as a method. I posit that the escalating disjunction between the critique of the object and the critique of theory is attributable to the deepening social fragmentation engendered by capitalist structures. This inherent characteristic underscores the imperative for a cohesive amalgamation of epistemic and socio-ontological critique. To elucidate Lukács’ model of critique, I will give particular attention to the chapter “What Is Orthodox Marxism?”. By doing this, I aim to elucidate Lukács’ assertion that the Marxist method facilitates a harmonious integration between the epistemic and socio-ontological dimensions of life, once it incorporates crucial categories such as historicity, totality, reciprocal action, and mediation. Furthermore, his method underscores the symbiotic relationship between some elements of the political economy and the German philosophical tradition, which shapes Lukács’ conceptualization of critique.