bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investment planning in the petroleum downstream infrastructure
Authors: Fiorencio Luiza , Oliveira Fabrício , Nunes Paula , Hamacher Silvio 
Published: August 2014

AbstractThe Brazilian oil industry has gained new momentum after the discovery of large oil reserves in deep under‐water. Numerous investments in the oil production chain are expected to support the scale of this operation. Given this context, the use of a decision support system (DSS), which encompasses the complexity of the oil supply chain to support investment decisions, becomes crucial. This paper proposes a DSS that is based on a mixed‐integer linear programming (MILP) model that allows the evaluation of different investment alternatives in logistics networks, such as expanding the capacity for transport, handling, and/or storage. Additionally, the DSS is composed of a database structure, business intelligence environment, and graphical visualization tool. The features of the proposed system were evaluated in two case studies. The first case study assesses the synergies between two projects: specifically the expansion of the berthing capacity of vessels in a marine terminal, and the increase in the transport capacity of the pipeline that connects the marine terminal to a distribution base. The second case study evaluates the dependency of the investment in sections of a pipeline that connects a refinery to several distribution bases. These case studies demonstrate the potential use of a DSS that currently optimizes investments in the Brazilian petroleum supply chain.
Reference Values of Pulse Wave Velocity in Healthy People from an Urban and Rural Argentinean Population
Authors: Díaz Alejandro , Galli Cintia , Tringler Matías , Ramírez Agustín , Cabrera Fischer Edmundo Ignacio 
Published: August 2014

In medical practice the reference values of arterial stiffness came from multicenter registries obtained in Asia, USA, Australia and Europe. Pulse wave velocity (PWV) is the gold standard method for arterial stiffness quantification; however, in South America, there are few population-based studies. In this research PWV was measured in healthy asymptomatic and normotensive subjects without history of hypertension in first-degree relatives. Normal PWV and the 95% confidence intervals values were obtained in 780 subjects (39.8 ± 18.5 years) divided into 7 age groups (10–98 years). The mean PWV found was 6.84 m/s ± 1.65. PWV increases linearly with aging with a high degree of correlation (r2=0.61;P<0.05) with low dispersion in younger subjects. PWV progressively increases 6–8% with each decade of life; this tendency is more pronounced after 50 years. A significant increase of PWV over 50 years was demonstrated. This is the first population-based study from urban and rural people of Argentina that provides normal values of the PWV in healthy, normotensive subjects without family history of hypertension. Moreover, the age dependence of PWV values was confirmed.Corrigendum to “Reference Values of Pulse Wave Velocity in Healthy People from an Urban and Rural Argentinean Population”
Surface biological, chemical, and optical properties of the Patagonian Shelf coccolithophore bloom, the brightest waters of the Great Calcite Belt
Authors: Balch W. M. , Drapeau D. T. , Bowler B. C. , Lyczkowski E. R. , Lubelczyk L. C. , Painter S. C. , Poulton A. J. 
Published: August 2014

We report surface observations of a mesoscale coccolithophore bloom at the shelf break of the Patagonian Shelf during December 2008, representing the densest coccolithophore population in the Southern Ocean. The bloom was most intense within the Falklands Current, northeast of the Falkland Islands. Emiliania huxleyi dominated bloom waters, with a mixed E. huxleyi and Prorocentrum sp. dinoflagellate bloom to the west and mixed assemblage of diatoms, dinoflagellates, and flagellates to the east. Optical measurements of coccolith light scattering, analytical measurements of their calcite, and microscopic counts all showed this to be an intense coccolithophore bloom. Average particulate inorganic carbon per coccolith in the bloom was low, typical of the B coccolith morphotype and in agreement with independent measurements made by scanning electron microscopy. Highest particulate inorganic carbon (measured optically and chemically) was observed when residual nitrate (defined as the difference, [NO3−1] − [Si(OH)4]) was 10–17 µmol L−1 and nitrate to phosphate ratios were close to Redfield values. Elevated particle backscattering was observed in the E. huxleyi bloom, whereas the highest particle scattering occurred in the adjoining Prorocentrum sp. bloom. Backscattering from coccolithophores represented up to 50% of the total backscattering (from organic and inorganic particles) along the main axis of the E. huxleyi bloom. Chlorophyll‐specific absorption in the coccolithophore bloom was typical of marine phytoplankton. Residual nitrate plotted vs. temperature showed that the E. huxleyi bloom was associated with waters between 5°C and 15°C, with depleted silicate. Results suggest that previous drawdown of silicate by diatoms occurred prior to the densest E. huxleyi blooms over the Patagonian Shelf. We speculate that such conditions might also be important for annual development of the broader Great Calcite Belt and other coccolithophore blooms..
Heterosexual Gender Relations and Masculinity in Fathers Who Smoke
Authors: Kwon Jae‐Yung , Oliffe John L. , Bottorff Joan L. , Kelly Mary T. 
Published: August 2014

AbstractThe purpose of this research was to explore the role of masculinity and heterosexual gender relations in new and expectant fathers' explanations of their continued smoking. We conducted a secondary analysis of in‐depth interviews with 20 fathers. Two themes were identified: (1) reconciling with partners to maintain a smoke‐free family home; and (2) smoking to self‐regulate emotions and maintain relationships. Fathers' decisions to smoke and changes in smoking behavior were shaped by ideals of masculinity and by partner relationships and family and social contexts, including division of domestic duties and childcare. Recognizing the influence of both masculinity and gender relations could provide new directions for supporting men's smoking cessation efforts during early parenthood. © 2014 The Authors. Research in Nursing & Health Published by Wiley Periodicals, Inc.
Effect of submarine groundwater discharge on the coastal ocean inorganic carbon cycle
Authors: Liu Qian , Charette Matthew A. , Henderson Paul B. , McCorkle Daniel C. , Martin William , Dai Minhan 
Published: August 2014

Using radium (Ra) isotopes, we estimate that the average submarine groundwater discharge (SGD) flux (marine plus terrestrial groundwater) into the southwest Florida Shelf (SWFS) was 20 ± 10 × 107 and 18 ± 8 × 107 m3 d−1 in July and October 2009, respectively. The terrestrial groundwater flux was the same order of magnitude as the local river discharge in July 2009. Shelf‐water total alkalinity (TAlk) and dissolved inorganic carbon (DIC) concentrations could not be explained by river inputs alone, suggesting a groundwater source. We estimated SGD fluxes of TAlk and DIC using the SGD flux derived from a shelf‐water 226Ra budget and TAlk and DIC concentration differences between the groundwater and seawater. These fluxes were also determined by the observed TAlk : 226Ra and DIC : 226Ra relationships in the shelf water, and the 226Ra flux sustained by SGD. These TAlk and DIC fluxes were 11–71 times more than the combined input of local rivers, suggesting that SGD was the dominant source of TAlk and DIC to the SWFS during 2009. SGD is an important component of the inorganic carbon budget for the coastal ocean.
Physical controls of oxygen fluxes at pelagic and benthic oxyclines in a lake
Authors: Kreling Julika , Bravidor Jenny , McGinnis Daniel F. , Koschorreck Matthias , Lorke Andreas 
Published: August 2014

We compared oxygen fluxes measured simultaneously at the pelagic and benthic oxycline in a lake and analyze their relation to hydrodynamic forcing conditions. While the mean oxygen fluxes did not differ significantly among both sites, the fluxes were highly variable in time. Short energetic periods contributed disproportionately to the overall oxygen flux above both the benthic and pelagic oxycline. In the pelagic region, mean fluxes across the oxycline were limited by low diffusivities (7 × 10−8 m2 s−1) and were one to two orders of magnitude smaller than fluxes above the oxycline (0.5 and 32 mmol m−2 d−1, respectively). A one‐dimensional transport model was used to estimate sources and sinks of oxygen potentially causing this imbalance. The model results indicate that 92% of dissolved oxygen transported into the oxycline is used by the respiration of organic material imported into the oxycline from the epilimnion; chemical oxygen consumption associated with the upward flux of reduced substances is negligible. Our findings indicate that under such conditions, dissolved oxygen consumption and therewith mineralization within the oxycline can be comparable with the corresponding rates occurring in the sediments of eutrophic lakes with an oxic hypolimnion.
Protein‐extending ACTN2 frameshift variants cause variable myopathy phenotypes by protein aggregation
Authors: Ranta‐aho Johanna , Felice Kevin J. , Jonson Per Harald , Sarparanta Jaakko , Yvorel Cédric , Harzallah Ines , Touraine Renaud , Pais Lynn , Austin‐Tse Christina A. , Ganesh Vijay S. , O'Leary Melanie C. , Rehm Heidi L. , Hehir Michael K. , Subramony Sub , Wu Qian , Udd Bjarne , Savarese Marco 
Published: August 2024

AbstractObjectiveThe objective of the study is to characterize the pathomechanisms underlying actininopathies.Distal myopathies are a group of rare, inherited muscular disorders characterized by progressive loss of muscle fibers that begin in the distal parts of arms and legs. Recently, variants in a new disease gene, ACTN2, have been shown to cause distal myopathy. ACTN2, a gene previously only associated with cardiomyopathies, encodes alpha‐actinin‐2, a protein expressed in both cardiac and skeletal sarcomeres. The primary function of alpha‐actinin‐2 is to link actin and titin to the sarcomere Z‐disk. New ACTN2 variants are continuously discovered; however, the clinical significance of many variants remains unknown. Thus, lack of clear genotype–phenotype correlations in ACTN2‐related diseases, actininopathies, persists.MethodsFunctional characterization in C2C12 cell model of several ACTN2 variants is conducted, including frameshift and missense variants associated with dominant and recessive actininopathies. We assess the genotype–phenotype correlations of actininopathies using clinical data from several patients carrying these variants.ResultsThe results show that the missense variants associated with a recessive form of actininopathy do not cause detectable alpha‐actinin‐2 aggregates in the cell model. Conversely, dominant frameshift variants causing a protein extension do form alpha‐actinin‐2 aggregates.InterpretationThe results suggest that alpha‐actinin‐2 aggregation is the disease mechanism underlying some dominant actininopathies, and thus, we recommend that protein‐extending frameshift variants in ACTN2 should be classified as pathogenic. However, this mechanism is likely elicited by only a limited number of variants. Alternative functional characterization methods should be explored to further investigate other molecular mechanisms underlying actininopathies.
Binary‐Cooperative Ultrathin Porous Membrane for Gas Separation
Authors: Wang Bo , Zhao Wen‐tai , Xu Xiao , Zhang Chen , Ding Shuai‐ying , Zhang Yue , Wang Tie 
Published: August 2024

AbstractThe construction of ultrathin porous membranes with stable structures is critical for achieving efficient gas separation. Inspired by the binary‐cooperative structural features of bones and teeth—composed of rigid hydroxyapatite and flexible collagen, which confer excellent mechanical strength—a binary‐cooperative porous membrane constructed with gel‐state zeolitic imidazolate frameworks (g‐ZIFs), synthesized using a metal‐gel‐induced strategy, is proposed. The enlarged cavity size and flexible frameworks of the g‐ZIF nanoparticles significantly improve gas adsorption and diffusion, respectively. After thermal treatment, the coordination structures forming rigid segments in the g‐ZIF membranes appear at the stacked g‐ZIF boundaries, exhibiting a higher Young's modulus than the g‐ZIF nanoparticles, denoted as the flexible segments. The g‐ZIF membranes demonstrate excellent tensile and compression resistances, attributed to the effective translation of binary‐cooperative effects of rigidity and flexibility into the membranes. The resulting dual‐aperture structure, composed of g‐ZIF nanoparticles surrounded by nanoscale apertures at the boundaries, yields a membrane with a stable CO2 permeance of 4834 GPU and CO2/CH4 selectivity of 90 within 3.0 MPa.
Accounting for the Quantum Capacitance of Graphite in Constant Potential Molecular Dynamics Simulations
Authors: Goloviznina Kateryna , Fleischhaker Johann , Binninger Tobias , Rotenberg Benjamin , Ers Heigo , Ivanistsev Vladislav , Meissner Robert , Serva Alessandra , Salanne Mathieu 
Published: August 2024

AbstractMolecular dynamics (MD) simulations at a constant electric potential are an essential tool to study electrochemical processes, providing microscopic information on the structural, thermodynamic, and dynamical properties. Despite the numerous advances in the simulation of electrodes, they fail to accurately represent the electronic structure of materials such as graphite. In this work, a simple parameterization method that allows to tune the metallicity of the electrode based on a quantum chemistry calculation of the density of states (DOS) is introduced. As a first illustration, the interface between graphite electrodes and two different liquid electrolytes, an aqueous solution of NaCl and a pure ionic liquid, at different applied potentials are studied. It is shown that the simulations reproduce qualitatively the experimentally‐measured capacitance; in particular, they yield a minimum of capacitance at the point of zero charge (PZC), which is due to the quantum capacitance (QC) contribution. An analysis of the structure of the adsorbed liquids allows to understand why the ionic liquid displays a lower capacitance despite its large ionic concentration. In addition to its relevance for the important class of carbonaceous electrodes, this method can be applied to any electrode materials (e.g. 2D materials, conducting polymers, etc), thus enabling molecular simulation studies of complex electrochemical devices in the future.
Design and Simulation of Bionic Quadruped Obstacle‐Overcoming Robot
Authors: Zhang Chenyang , Zhao Jieliang , Zhang Tianyu , Niu Qun , Gu Yongxia , Yan Shaoze , Wang Wenzhong 
Published: August 2024

AbstractAdvances in bionic technology have enabled quadruped robots to be more flexible. Numerous quadruped robots in various forms specialize in walking and trotting, whereas very few robots achieve high‐performance obstacle‐overcoming. A bionic quadruped standing long jump obstacle‐overcoming robot is presented. By using two synchronous belts and energy storage, this robot is capable of high‐performance jumping. A flexible spine for the bionic quadruped obstacle‐overcoming robot is also presented to achieve energy storage and shock absorption during obstacle‐overcoming. Furthermore, the control framework by establishing the dynamic models of the single limb is proposed. To validate the feasibility and accuracy of the design theory and robot scheme, simulations are conducted. The results of these simulations clearly illustrate the robot's ability to successfully overcome obstacles of varying heights, thereby affirming the correctness of its limb dynamics models. In comparison to traditional quadruped robots, the bionic quadruped obstacle‐overcoming robot proves its efficacy in navigating challenging terrains.
Sonodynamic Treatment Triggers Cancer Cell Killing by Doxorubicin in P‐Glycoprotein‐Mediated Multidrug Resistant Cancer Models
Authors: Foglietta Federica , Giacone Marta , Durando Gianni , Canaparo Roberto , Serpe Loredana 
Published: August 2024

AbstractDoxorubicin is a widely used chemotherapeutic agent that can be hampered in its efficacy by the occurrence of multidrug resistance (MDR), due to the overexpression of the drug efflux transporter P‐glycoprotein. As overcoming MDR still remains an unmet clinical need, this work aims at investigating an innovative strategy. Sonodynamic therapy (SDT) selectively kills cancer cells by combining low‐intensity ultrasound (US) with a responsive chemical agent (sonosensitiser) that can be activated to produce reactive oxygen species (ROS). Therefore, the efficacy of SDT, using doxorubicin as sonosensitiser, is studied on human MDR ovarian (A2780/MDR) and colon (HT‐29/MDR) cancer cells. The ultrasound exposure of MDR cells pre‐incubated with non‐cytotoxic concentrations of doxorubicin for 1 h has induced a statistically significant decrease of cell proliferation after 72 h. Interestingly, US has selectively triggered the ROS‐mediated cytotoxicity of the doxorubicin entrapped into the cancer cell membrane leading to necrotic cancer cell death by lipid peroxidation. Moving from 2D to 3D HT‐29/MDR cell cultures, the ability of SDT to reduce the growth of MDR spheroids by inducing significant necrotic cancer cell death is also confirmed. In conclusion, SDT can have a role in treating MDR tumors by eliciting the ROS‐mediated cytotoxicity of doxorubicin.
Enhanced Fast‐Discharging Performance and Cyclability in Oxygen‐Redox‐Based P3‐Type Na‐Layered Cathode via Vacancies in TM layers
Authors: Lee Sang‐Yeop , Kweon Hyunji , Lee Sangyeop , Cho Min‐kyung , Ahn Hobin , Ahn Jinho , Ku Bonyoung , Choi Myungeun , Jung Hun‐Gi , Shin Dong Ok , Kim Jongsoon 
Published: August 2024

AbstractOxygen redox in layered oxide cathodes for Na‐ion batteries is considered a promising approach for improving the energy density. However, oxygen‐redox‐based cathodes suffer from sluggish kinetics and undesirable structural change during charge/discharge, leading to poor electrochemical performances. Herein, introducing vacancies (□) in the transition metal layers enables the enhanced oxygen redox‐based electrochemical performances in the P3‐type Mn‐based layered oxide cathode is demonstrated. The vacancies can play a role of the local distortion buffers, resulting in the enhanced oxygen redox kinetics and the suppressed structural deformation such as P3‐O3(II) phase transition. The oxygen‐redox‐based P3‐type Na0.56[Ni0.1Mn0.81□0.09]O2 exhibits the large discharge capacity of ≈140.95 mAh g−1 at 26 mA g−1 with a high average discharge voltage of ≈3.54 V (vs Na+/Na). Even at 650 mA g−1, its discharge capacity and average operation voltages delivered ≈122.06 mAh g−1 and ≈3.22 V, respectively. Especially, the small gap of average discharge voltage indicates both improves power‐capability and enhanced kinetics of oxygen redox in P3‐type Na0.56[Ni0.1Mn0.81□0.09]O2. Moreover, the vacancy buffer in the transition metal layers results in the stable cycle‐performance of P3‐type Na0.56[Ni0.1Mn0.81□0.09]O2 with the capacity retention of ≈80.80% for 100 cycles, due to the suppressed P3‐O3(II) phase transition.
Phase II study of long‐course chemoradiotherapy followed by consolidation chemotherapy as total neoadjuvant therapy in locally advanced rectal cancer in Japan: ENSEMBLE‐2
Authors: Kagawa Yoshinori , Ando Koji , Uemura Mamoru , Watanabe Jun , Oba Koji , Emi Yasunori , Matsuhashi Nobuhisa , Izawa Naoki , Muto Osamu , Kinjo Tatsuya , Takemasa Ichiro , Oki Eiji 
Published: August 2024

AbstractAimTo evaluate the feasibility and safety of total neoadjuvant therapy with long‐course chemoradiotherapy followed by consolidation chemotherapy in Japanese patients with locally advanced rectal cancer.MethodsThis prospective, multicenter, single‐arm, phase II trial was conducted at 10 centers. The eligibility criteria included age ≥20 y, locally advanced rectal cancer within 12 cm of the anal verge, and cT3‐4N0M or TanyN+M0 at diagnosis, enabling curative resection. The protocol treatment was capecitabine (1650 mg/m2/day)‐based long‐course chemoradiotherapy (50.4 Gy/28 fractions) and consolidation chemotherapy (CAPOX, four courses) followed by total mesorectal excision. Nonoperative management was allowed if a clinical complete response was achieved. The primary endpoint was the pathologic complete response rate.ResultsAmong 28 enrolled patients (19 men, 9 women; median age, 69.5 [41–79] y), the long‐course chemoradiotherapy and consolidation chemotherapy completion rates were 100% and 96.4%, respectively. The clinical responses included clinical complete response, (35.7%, 10/28), near‐complete response (28.6%, 8/28), and incomplete response (32.1%, 9/28). Total mesorectal excision and nonoperative management were performed in 21 and six patients, respectively. The final analysis included 21 patients. Five patients (23.8% [90% confidence interval 11.8%–41.8%]) achieved pathologic complete response, while 10 of 28 patients (35.7%) achieved a pathological complete response or a sustained clinical complete response. No treatment‐related deaths occurred. Grade ≥3 adverse events included diarrhea (7.1%) and leukopenia (7.1%).ConclusionENSEMBLE‐2 demonstrated comparable pathologic complete response rates and well‐tolerated safety of total neoadjuvant therapy with long‐course chemoradiotherapy followed by consolidation chemotherapy in Japanese patients with locally advanced rectal cancer.
Early Eocene infructescences from Argentine Patagonia expand the biogeography of Malvoideae
Authors: Siegert Caroline , Gandolfo Maria A. , Wilf Peter 
Published: August 2024

AbstractPremiseFossil infructescences and isolated fruits with characters of Malvoideae, a subfamily of Malvaceae (mallow family), were collected from early Eocene sediments in Chubut, Argentina. The main goals of this research are to describe and place these fossils systematically, and to explore their biogeographical implications.MethodsFossils were collected at the Laguna del Hunco site, Huitrera Formation, Chubut, Patagonia, Argentina. They were prepared, photographed, and compared with extant and fossil infructescences and fruits of various families using herbarium material and literature.ResultsThe infructescences are panicles with alternate arrangement of fruits. They bear the fruits on short pedicels that are subtended by a bract; the fruits display an infracarpelar disk and split to the base into five ovate sections interpreted as mericarps. Each mericarp is characterized by an acute apex and the presence of a longitudinal ridge. The isolated fruits show the same features as those on the infructescences. The fossils share unique features with members of the cosmopolitan family Malvaceae, subfamily Malvoideae.ConclusionsThe fossils have a unique combination of characters that does not conform to any previously described genus, justifying the erection of a new genus and species, Uiher karuen. This new taxon constitutes the first known Malvoideae reproductive fossils of the Southern Hemisphere, expanding the distribution of Malvoideae during the early Eocene.