bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging molecular networks in Burkitt's lymphoma
Authors: Mangani Davide , Roberti Annalisa , Rizzolio Flavio , Giordano Antonio 
Published: August 2012

AbstractBurkitt's lymphoma (BL), one of the most aggressive tumors affecting humans, characterized by the constitutive activation of the Myc oncogene together with the alteration of many other genetic and epigenetic factors. Among them, the INK4a/ARF locus has been well documented to play a central role in BL. Recently, we have discovered that simultaneous deregulation of both DNA methylation patterns and the ubiquitin‐dependent proteolysis system is required to completely inactive the INK4/ARF locus, opening new possibilities for treating Burkitt's lymphoma. In this review, we integrate our discovery with the general view of BL and propose a new comprehensive approach to analyze and manage this aggressive disease. J. Cell. Biochem. 114: 35–38, 2012. © 2012 Wiley Periodicals, Inc.
Perspective from the heart: The potential of human pluripotent stem cell‐derived cardiomyocytes
Authors: Xu Xiu Qin , Sun William 
Published: August 2012

AbstractHuman pluripotent stem cells (hPSC) are self‐renewing cells with the potential to differentiate into a variety of human cells. They hold great promise for regenerative medicine and serve as useful in vitro models for studying human biology. For the past few years, there is vast interest in applying these cells to advance cardiovascular medicine. Human cardiomyocytes can be readily generated from hPSC and they have been characterized extensively with regards to molecular and functional properties. They have been transplanted into animal models of cardiovascular diseases and also shown to be potentially useful reagents for drug discovery. Yet, despite great progress in this field, significant technical hurdles remain before these cells could be used clinically or for pharmaceutical research and development. Further research using novel approaches will be required to overcome these bottlenecks. J. Cell. Biochem. 114: 39–46, 2012. © 2012 Wiley Periodicals, Inc.
Contrast‐enhanced multidetector‐row computed tomography vs. time‐resolved magnetic resonance angiography vs. contrast‐enhanced perfusion MRI: Assessment of treatment response by patients with inoperable chronic thromboembolic pulmonary hypertension
Authors: Ohno Yoshiharu , Koyama Hisanobu , Yoshikawa Takeshi , Nishio Mizuho , Matsumoto Sumiaki , Matsumoto Keiko , Aoyama Nobukazu , Nogami Munenobu , Murase Kenya , Sugimura Kazuro 
Published: August 2012

AbstractPurpose:To compare therapeutic effect assessment capability of multidetector‐row computed tomography (MDCT), magnetic resonance angiography (MRA), and dynamic perfusion MRI for chronic thromboembolic pulmonary hypertension (CTEPH) patients.Materials and Methods:Twenty‐four consecutive CTEPH patients treated with conventional therapy underwent pre‐ and posttherapeutic MDCT, MRA, dynamic perfusion MRI, 6‐minute walk distance (6‐MWD), cardiac ultrasound (US), and right heart catheterization. According to therapeutic results, all patients were divided into response (n = 13) and nonresponse (n = 11) groups. CTEPH indexes for MDCT (CTEPHCT) and MRA (CTEPHMRA) were calculated on the basis of embolic burden. Pulmonary perfusion parameter maps were generated from all perfusion MR data, followed by determination of improvements in mean perfusion parameter at regions of interest (ROIs) for each patient. Receiver operating characteristic (ROC)‐based positive tests were performed to determine the feasible threshold values for distinguishing two groups. Finally, diagnostic capabilities were compared by means of McNemar's test.Results:When feasible threshold values adapted, specificity (90.9 〈10/11〉%, P < 0.05) and accuracy (95.8 〈23/24〉%, P < 0.05) for improvement in pulmonary blood flow were significantly higher than those for CTEPHCTA (specificity: 36.4 〈4/11〉%, accuracy: 70.8 〈17/24〉%).Conclusion:Dynamic perfusion MRI has better capability for assessment of therapeutic effect on CTEPH patients than does MDCT. J. Magn. Reson. Imaging 2012;36:612–623. © 2012 Wiley Periodicals, Inc.
MRI temporal acceleration techniques
Authors: Tsao Jeffrey , Kozerke Sebastian 
Published: August 2012

AbstractIn recent years, there has been an explosive growth of magnetic resonance imaging (MRI) techniques that allow faster scan speed by exploiting temporal or spatiotemporal redundancy of the images. These techniques improve the performance of dynamic imaging significantly across multiple clinical applications, including cardiac functional examinations, perfusion imaging, blood flow assessment, contrast‐enhanced angiography, functional MRI, and interventional imaging, among others. The scan acceleration permits higher spatial resolution, increased temporal resolution, shorter scan duration, or a combination of these benefits. Along with the exciting developments is a dizzying proliferation of acronyms and variations of the techniques. The present review attempts to summarize this rapidly growing topic and presents conceptual frameworks to understand these techniques in terms of their underlying mechanics and connections. Techniques from view sharing, keyhole, k‐t, to compressed sensing are covered. J. Magn. Reson. Imaging 2012;36:543–560. © 2012 Wiley Periodicals, Inc.
Impact of hepatectomy for huge solitary hepatocellular carcinoma
Authors: Ariizumi Shun‐ichi , Kotera Yoshihito , Takahashi Yutaka , Katagiri Satoshi , Yamamoto Masakazu 
Published: August 2012

AbstractBackgroundTo evaluate the surgical outcome of patients with huge solitary hepatocellular carcinoma (HCC, ≥10 cm in diameter) without major vascular invasion.MethodsWe retrospectively studied 177 patients with huge HCC (≥10 cm in diameter) who underwent hepatectomy from 1990 to 2008. Surgical outcomes and clinicopathological characteristics were compared among 54 patients with solitary HCC without a major portal vein tumor thrombus (MPVT), 53 patients with multiple HCCs without MPVT, and 70 patients who have HCC with MPVT.ResultsThe mean tumor size and indocyanine green retention rate at 15 min showed no significant difference among patients groups. The overall 5‐year survival rate was significantly higher in patients with solitary HCC (79%) than in patients with multiple HCCs (31%, P < 0.0001) and MPVT (17%, P < 0.0001). In patients who underwent curative surgery, the 5‐year disease‐free survival rate was significantly higher in patients with solitary HCC (48%) than in patients with multiple HCCs (12%, P = 0.0008) and MPVT (12%, P = 0.0003). Multivariate analysis showed solitary HCC to be a significant independent prognostic factor for overall survival and disease‐free survival.ConclusionsPatients with solitary HCC without MPVT show a favorable surgical outcome even for tumor size ≥10 cm in diameter. J. Surg. Oncol. 2013;107:408–413. © 2012 Wiley Periodicals, Inc.
Diagnostic and prognostic significance of serum MicroRNAs in colorectal cancer
Authors: Menéndez Pablo , Villarejo Pedro , Padilla David , Menéndez José M. , Montes Jose A. Rodríguez 
Published: August 2012

AbstractMicroRNAs are short non‐coding RNA molecules involved in the regulation of gene expression. There are few studies related to the determination of serum microRNAs in colorectal cancer. The identification of microRNAs in peripheral blood as noninvasive markers of tumor disease may lead to potential applications, although further clinical studies focusing on serum microRNAs are required to determine their clinical significance for the diagnosis and prognosis outcome of colorectal cancer. J. Surg. Oncol. 2013;107:217–220. © 2012 Wiley Periodicals, Inc.
THAP1 mutations and dystonia phenotypes: Genotype phenotype correlations
Authors: Xiromerisiou Georgia , Houlden Henry , Scarmeas Nikolaos , Stamelou Maria , Kara Eleanna , Hardy John , Lees Andrew J. , Korlipara Prasad , Limousin Patricia , Paudel Reema , Hadjigeorgiou Georgios M. , Bhatia Kailash P. 
Published: August 2012

AbstractTHAP1 mutations have been shown to be the cause of DYT6. A number of different mutation types and locations in the THAP1 gene have been associated with a range of severity and dystonia phenotypes, but, as yet, it has been difficult to identify clear genotype phenotype patterns. Here, we screened the THAP1 gene in a further series of dystonia cases and evaluated the mutation pathogenicity in this series as well as previously reported mutations to investigate possible phenotype‐genotype correlations. THAP1 mutations have been identified throughout the coding region of the gene, with the greatest concentration of variants localized to the THAP1 domain. In the additional cases analyzed here, a further two mutations were found. No obvious, indisputable genotype‐phenotype correlation emerged from these data. However, we managed to find a correlation between the pathogenicity of mutations, distribution, and age of onset of dystonia. THAP1 mutations are an important cause of dystonia, but, as yet, no clear genotype‐phenotype correlations have been identified. Greater mutation numbers in different populations will be important and mutation‐specific functional studies will be essential to identify the pathogenicity of the various THAP1 mutations. © 2012 Movement Disorder Society
Association between occupational stress and risk of overactive bladder and other lower urinary tract symptoms: A cross‐sectional study of female nurses in China
Authors: Zhang Chunfang , Hai Ting , Yu Luping , Liu Shijun , Li Qing , Zhang Xiaowei , Xu Tao , Wang Xiaofeng 
Published: August 2012

AbstractAimsTo evaluate the prevalence of overactive bladder (OAB) and other lower urinary tract symptoms (LUTS), and their association with occupational stress in female nurses in China.MethodsFrom September 2010 to March 2011, 1,135 registered female nurses with one or more years of nursing experience, were cluster‐sampled. The participants completed questionnaires on LUTS‐related symptoms and Occupational Stress Inventory‐Revised (OSI‐R) tests. Multiple logistic regressions were performed to evaluate the independent impact of perceived occupational stress on OAB and other LUTS, adjusting for age, body mass index (BMI), and history of childbearing and pelvic surgery.Results1,070 valid responses to questionnaires were obtained. The prevalence of OAB was 27.57% (95% CI: 24.89–30.25%). LUTS of any types occured in 89.63% of nurses, with 64.39% reporting urgency, 27.10% reporting increased daytime frequency, 17.88% reporting nocturia and 21.03% reporting urge incontinence. The occupational stress and psychological strain levels of nurses were higher than those of normative populations, while their coping resources were lower. Most of the sub‐scales of occupational stress and psychological strain showed higher results for nurses with OAB than for those OAB‐free, while coping resources were not found to make any statistically significant differences. After adjusting age, BMI, and childbearing and pelvic surgery history, each sub‐scale of OSI‐R was found to be associated with at least one type of LUTS.ConclusionsThe prevalence of OAB and other LUTS is high among female nurses in China, and occupational stress may be a contributing factor. Neurourol. Urodynam. 32: 254–260, 2013. © 2012 Wiley Periodicals, Inc.
Economic lot sizing with constant capacities and concave inventory costs
Authors: Ou Jinwen 
Published: August 2012

AbstractThis article studies the classical single‐item economic lot‐sizing problem with constant capacities, fixed‐plus‐linear order costs, and concave inventory costs, where backlogging is allowed. We propose an O(T3) optimal algorithm for the problem, which improves upon the O(T4) running time of the famous algorithm developed by Florian and Klein (Manage Sci18 (1971) 12–20). Instead of using the standard dynamic programming approach by predetermining the minimal cost for every possible subplan, we develop a backward dynamic programming algorithm to obtain a more efficient implementation. © 2012 Wiley Periodicals, Inc. Naval Research Logistics, 2012
Kana Tamata or Feasts of Men: An Interdisciplinary Approach for Identifying Cannibalism in Prehistoric Fiji
Authors: Jones S. , Walsh‐Haney H. , Quinn R. 
Published: August 2012

AbstractBy integrating osteological, taphonomic, archaeological and stable isotopic data, we test for cannibalism in the Lau Group, Fiji and discuss the potential underlying cause(s) and context(s) of this behaviour. First, we compare taphonomic and element representations of human skeletal material from two contexts in Fiji, examining human bone fragments from archaeological sites, including middens and burials in the Lau Island Group. Fourteen sites produced human remains. Only two of those sites included distinct human burial contexts, but in the remaining 12 sites, the human bone was recovered from middens or contexts where midden was mixed with possible secondary burials. A total of 262 number of identified specimens per species, representing an estimated 15 minimum number of individuals make up the Lau human assemblage. Second, we analysed bones contained in 20 individual human burials from four different sites that are housed at the Fiji Museum for comparative purposes. Third, we examine previously published stable isotopic (δ13C, δ15N) analysis of bone collagen to gauge protein consumption of likely cannibalised humans in midden contexts and potential cannibals from primary burials. We model a cannibalistic diet category within the context of isotopically measured Pacific Islands food groups and apply an isotopic mixing model to gauge plausible dietary contributions from six sources including human flesh. Isotopic mixing models of the Lauan samples illustrate a high diversity in reconstructed diets. The percent contribution of human flesh is low for all individual Lauans. We conclude that mortuary rituals evidenced by sharp‐force trauma may suggest non‐nutritive and non‐violent practices that may have included the consumption of small amounts of human flesh. Copyright © 2012 John Wiley & Sons, Ltd.
Laser processing of TiO2 films for dye solar cells: a thermal, sintering, throughput and embodied energy investigation
Authors: Mincuzzi G. , Schulz‐Ruhtenberg M. , Vesce L. , Reale A. , Di Carlo A. , Gillner A. , Brown T. M. 
Published: August 2012

ABSTRACTWe have analysed and optimised a laser process for the sintering of the TiO2 layers in dye solar cells (DSCs). Through a thermographic characterisation of the process, we show that it is possible to scale and process large areas uniformly (16 cm2). We fabricated DSCs with nanocrystalline (nc)‐TiO2 films sintered by using pulsed ultraviolet laser with an average output power P varying from 1 W to 7 W whilst mainting a constant power conversion efficiency η. The highest efficiency reached for a laser sintered DSC was 7%. The time required to sinter 1 m2 of nc‐TiO2 film was found to decrease hyperbolically with P, which is important for determining process takt times. We quantified the embodied energy (EE) required to sinter 1 m2 of the active TiO2 layer for a variety of different processes, and found that the EE for the laser sintering process with a system wall plug efficiency of 3.5% to be competitive with the more conventional oven and belt furnace treatments. We outline the main features required from a laser system to carry out an efficient, energetically favourable and industrially applicable automated process with competitive throughput. Copyright © 2012 John Wiley & Sons, Ltd.
Organic solvent‐free catalytic hydrogenation of diene‐based polymer nanoparticles in latex form. Part II. Kinetic analysis and mechanistic study
Authors: Wang Hui , Yang Lijuan , Scott Stephen , Pan Qinmin , Rempel Garry L. 
Published: August 2012

AbstractThe central challenge that has limited the development of catalytic hydrogenation of diene‐based polymer latex (i.e., latex hydrogenation) in large‐scale production pertains to how to accomplish the optimal interplay of accelerating the hydrogenation rate, decreasing the required quantity of catalyst, and eliminating the need for an organic solvent. Here, we attempt to overcome this dilemma through decreasing the dimensions of the polymer substrate (such as below 20 nm) used in the hydrogenation process. Very small diene‐based polymer nanoparticles were synthesized and then used as the substrates for the subsequent latex hydrogenation. The effects of particle size, temperature, and catalyst concentration on the hydrogenation rate were fully investigated. An apparent first‐order kinetic model was proposed to describe the rate of hydrogen uptake with respect to the concentration of the olefinic substrate (CC). Mass transfer of both the hydrogen and catalyst involved in this solid (polymer)–liquid (water)–gas (hydrogen) three‐phase latex system is discussed. The competitive coordination of the catalyst between the CC and acrylonitrile units within the copolymer was elucidated. It was found that (1) using very small diene‐based polymer nanoparticles as the substrate, the hydrogenation rate of polymer latex can be increased vastly to achieve a high conversion of 95% while a quite low level of catalyst loading is required; (2) this latex hydrogenation process was completely free of organic solvent and no cross‐linking was found; (3) the mass transfer of hydrogen is not a rate‐determining step in the present hydrogenation reactions; (4) the catalyst was dispersed homogeneously within the polymer nanoparticles; (5) for the reaction that has reached about 95 mol % conversion, the kinetic study shows that the reaction is chemically controlled with an apparent activation energy of 100–110 kJ/mol; (6) the strong coordination of C[tbond]N to the catalytically active species RhH2Cl(PPh3)2 imposed a negative effect on the hydrogenation activity. The present research provides a comprehensive study to appreciate the underlying chemistry of latex hydrogenation of diene‐based polymer nanoparticles and more importantly shows great promise toward the commercialization of a “green” catalytic hydrogenation operation of a diene‐based polymer latex in industry. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Synthesis of nitroxide‐containing block copolymers for the formation of organic cathodes
Authors: Hauffman Guillaume , Rolland Julien , Bourgeois Jean‐Pierre , Vlad Alexandru , Gohy Jean‐François 
Published: August 2012

AbstractThis contribution describes the polymerization of 2,2,6,6‐tetramethylpiperidin‐4‐yl methacrylate by atom transfer radical polymerization (ATRP). Different catalytic systems are compared. The CuCl/4,4′‐dinonyl‐2,2′‐dipyridyl catalytic system allows a good control over the polymerization and provides polymers with a polydispersity index below 1.2. The successful polymerization of styrene from PTMPM‐Cl macroinitiators by ATRP is then demonstrated. Successful quantitative oxidation of PTMPM‐b‐PS block copolymers leads to poly(2,2,6,6‐tetramethylpiperidinyloxy‐4‐yl‐methacrylate)‐b‐poly(styrene) (PTMA‐b‐PS). The cyclic voltammogram of PTMA‐b‐PS indicates a reversible redox reaction at 3.6 V (vs. Li+/Li). Such block copolymers open new opportunities for the formation of functional organic cathode materials. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013
Tuning photovoltaic performance of 9,9‐dioctylfluorene‐alt‐5,7‐bis(thiophen‐2‐yl)‐2,3‐biphenylthieno[3,4‐b]pyrazine copolymeric derivatives by attaching additional donor units in pendant phenyl ring
Authors: Li Jianmin , Deng Xianping , Zhang Zhiyong , Wang Yafei , Liu Yu , He Keqi , Huang Ying , Tao Qiang , Quan Lixia , Zhu Weiguo 
Published: August 2012

AbstractA class of the 9,9‐dioctylfluorene‐alt‐5,7‐bis(thiophen‐2‐yl)‐2,3‐biphenylthieno [3,4‐b]pyrazine copolymeric derivatives (PFO‐3ThPz‐D) attaching additional donor (D) units in the pendant phenyl ring with a D‐A
D structure was synthesized and investigated, where the additional D unit is a substituent group of fluorene, carbazole, and triphenylamine (Tpa). Their photovoltaic properties were significantly tuned by these pending donor units. Among these copolymers, the PFO‐3ThPz‐Tpa exhibited the best photovoltaic properties in the bulk heterojunction polymeric solar cells (BHJ‐PSC). The maximum power conversion efficiency (PCE) of 2.09% and the highest circuit current density (Jsc) of 7.91 mA/cm2 were obtained in the cell using a blend of PFO‐3ThPz‐Tpa and PC60BM (1:3, w/w) as active layer, which are 2.5 and 1.8 times higher than those corresponding levels in the other cell using the parent PFO‐3ThPz‐Ph copolymer instead of PFO‐3ThPz‐Tpa as donor, respectively. While PC60BM was replaced by PC70BM, the PFO‐3ThPz‐Tpa‐based BHJ‐PSC exhibited better photovoltaic properties with PCE of 3.08% and Jsc of 10.3 mA/cm2. This work demonstrated that attaching donor units into the D‐A‐based copolymeric side‐chain is a simple and effective method to improve the photovoltaic properties for the resulting copolymers. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Facile synthesis of ABCDE‐type H‐shaped quintopolymers by combination of ATRP, ROP, and click chemistry and their potential applications as drug carriers
Authors: Liu Huanhuan , Li Shixian , Zhang Meijing , Shao Wei , Zhao Youliang 
Published: August 2012

AbstractA facile approach to synthesis of ABCDE‐type H‐shaped quintopolymer comprising polystyrene (PSt, C) main chain and poly(ethylene glycol) (PEG, A), poly(ε‐caprolactone) (PCL, B), poly(L‐lactide) (PLLA, D), and poly(acrylic acid) (PAA, E) side chains was described, and physicochemical properties and potential applications as drug carriers of copolymers obtained were investigated. Azide‐alkyne cycloaddition reaction and hydrolysis were used to synthesize well‐defined H‐shaped quintopolymer. Cytotoxicity studies revealed H‐shaped copolymer aggregates were nontoxic and biocompatible, and drug loading and release properties were affected by macromolecular architecture, chemical composition, and pH value. The release rate of doxorubicin from copolymer aggregates at pH 7.4 was decreased in the order PAA‐b‐PLLA > H‐shaped copolymer > PEG‐PCL‐PSt star, and the release kinetics at lower pH was faster. The H‐shaped copolymer aggregates have a potential as controlled delivery vehicles due to their excellent storage stability, satisfactory drug loading capacity, and pH‐sensitive release rate of doxorubicin. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012
Alternating copolymers of hexafluoroisobutylene with vinyl trifluoroacetate and vinyl pentafluorobenzoate
Authors: Mikes Frantisek , Teng Hongxiang , Koike Yasuhiro , Okamoto Yoshiyuki 
Published: August 2012

AbstractCopolymerizations of hexafluoroisobutylene (HFIB) with vinyl pentafluorobenzoate (VPFB) and vinyl trifluoroacetate (VTFA) were carried out in bulk using perfluorodibenzoyl peroxide as the radical initiator. The copolymers obtained were characterized by proton and fluorine NMR spectroscopy. The monomer reactivity ratios in the polymerization of HFIB with VPFB were r1 (HFIB) = 0, r2 (VPFB) = 0.373, and r1r2 = 0. The results indicated that these copolymers have alternating structures. Similarly, the copolymers of HFIB and VTFA also showed alternating structures. The films of HFIB‐co‐VPFB were prepared by casting THF solution of polymers. Films obtained were flexible and transparent. The refractive indices of copolymers were 1.4549, 1.4490, and 1.4438 at 532, 633, and 839 nm, respectively. The average Tgs of HFIB‐co‐VTFA and HFIB‐co‐VPFB were 52 and 71 °C, respectively. From these results, the Tg of the hypothetical HFIB homopolymer is postulated to be in between 70 and 90 °C, which may be useful in the assessment of Tgs of HFIB copolymers with other vinyl monomers. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012