bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Development and Utility of a Novel Scale That Quantifies the Glycemic Progression Toward Type 1 Diabetes Over 6 Months
Authors: Sosenko Jay M. , Skyler Jay S. , Beam Craig A. , Boulware David , Mahon Jeffrey L. , Krischer Jeffrey P. , Greenbaum Carla J. , Rafkin Lisa E. , Matheson Della , Herold Kevan C. , Palmer Jerry P. ,   the Type 1 Diabetes TrialNet and Diabetes Prevention Trial–Type 1 Study Groups
Published: March 2015

OBJECTIVE
We developed a scale to serve as a potential end point for 6-month glycemic progression (PS6M) toward type 1 diabetes (T1D) in autoantibody-positive relatives of individuals with T1D.

RESEARCH DESIGN AND METHODS
The PS6M was developed from Diabetes Prevention Trial–Type 1 (DPT-1) data and tested in the TrialNet Pathway to Prevention Study (PTP). It is the difference between 6-month glucose sum values (30–120 min oral glucose tolerance test values) and values predicted for nonprogressors.

RESULTS
The PS6M predicted T1D in the PTP (P &lt; 0.001). The area under the receiver operating chacteristic curve was greater (P &lt; 0.001) for the PS6M than for the baseline–to–6-month difference. PS6M values were higher in those with two or more autoantibodies, 30–0 min C-peptide values &lt;2.00 ng/mL, or DPT-1 Risk Scores &gt;7.00 (P &lt; 0.001 for all).

CONCLUSIONS
The PS6M is an indicator of short-term glycemic progression to T1D that could be a useful tool for assessing preventive treatments and biomarkers.
Efficacy and Safety of Saxagliptin in Older Participants in the SAVOR-TIMI 53 Trial
Authors: Leiter Lawrence A. , Teoh Hwee , Braunwald Eugene , Mosenzon Ofri , Cahn Avivit , Kumar K.M. Prasanna , Smahelova Alena , Hirshberg Boaz , Stahre Christina , Frederich Robert , Bonnici Francois , Scirica Benjamin M. , Bhatt Deepak L. , Raz Itamar ,   for the SAVOR-TIMI 53 Steering Committee and Investigators
Published: March 2015

OBJECTIVE
To examine the safety and cardiovascular (CV) effects of saxagliptin in the predefined elderly (≥65 years) and very elderly (≥75 years) subpopulations of the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus–Thrombolysis in Myocardial Infarction 53 (SAVOR-TIMI 53) trial.

RESEARCH DESIGN AND METHODS
Individuals ≥40 years (n = 16,492; elderly, n = 8,561; very elderly, n = 2,330) with HbA1c ≥6.5% (47.5 mmol/mol) and ≤12.0% (107.7 mmol/mol) were randomized (1:1) to saxagliptin (5 or 2.5 mg daily) or placebo in a double-blind trial for a median follow-up of 2.1 years.

RESULTS
The hazard ratio (HR) for the comparison of saxagliptin versus placebo for the primary end point (composite of CV mortality, myocardial infarction, or ischemic stroke) was 0.92 for elderly patients vs. 1.15 for patients &lt;65 years (P = 0.06) and 0.95 for very elderly patients. The HRs for the secondary composite end points in the entire cohort, elderly cohort, and very elderly cohort were similar. Although saxagliptin increased the risk of hospitalization for heart failure in the overall saxagliptin population, there was no age-based treatment interaction (P = 0.76 for elderly patients vs. those &lt;65 years; P = 0.34 for very elderly patients vs. those &lt;75 years). Among saxagliptin-treated individuals with baseline HbA1c ≥7.6% (59.6 mmol/mol), the mean change from baseline HbA1c at 2 years was −0.69%, −0.64%, −0.66%, and −0.66% for those ≥65, &lt;65, ≥75, and &lt;75 years old, respectively. The incidence of overall adverse events (AEs) and serious AEs was similar between saxagliptin and placebo in all cohorts; however, hypoglycemic events were higher for saxagliptin versus placebo regardless of age.

CONCLUSIONS
The SAVOR-TIMI 53 trial supports the overall CV safety of saxagliptin in a robust number of elderly and very elderly participants, although the risk of heart failure hospitalization was increased irrespective of age category. AEs and serious AEs as well as glycemic efficacy of saxagliptin in elderly patients are similar to those found in younger patients.
The Effect Of Sodium Alginate Concentration On The Rheological Parameters Of Spinning Solutions
Authors: Brzezińska Magdalena , Szparaga Grzegorz 
Published: March 2015

Abstract
The aim of the study was to determine the rheological properties of solutions of two types of sodium alginate in water. Rheological studies were carried out to determine the rheological properties of the spinning solutions. Polymer solutions of different concentrations were obtained. Based on the preliminary research of the concentrations of solutions, the proper n and k parameters were selected in order to obtain fibre by wet spinning from solution method. For selected concentrations of polymer solutions, the calcium alginate fibres were obtained.
Prodromus of moth flies (Diptera: Psychodidae) from Slovakia
Authors: Oboňa Jozef , Ježek Jan 
Published: March 2015

Abstract
First records of fourteen species of moth flies are from Slovakia mentioned: Apsycha pusilla (Tonnoir, 1922), Clytocerus (Boreoclytocerus) splendidus Ježek & Hájek, 2007, C. (B.) tetracorniculatus Wagner, 1977, Jungiella (Jungiella) hygrophila Ježek, 1987, J. (J.) valachica (Vaillant, 1963), J. (Psychocha) laminata (Szabó, 1960), Parajungiella prikryli Ježek, 1999, Pericoma (Pericoma) exquisita Eaton, 1893, P. (P.) ljubiniensis Krek, 1969, P. (P.) vestita Vaillant & Withers, 1993, Psychoda alticola Vaillant, 1973, P. uniformata Haseman, 1907, Pneumia compta (Eaton, 1893) and P. kabelaki Omelková & Ježek, 2012. Records on the basis of larvae of Berdeniella manicata (Tonnoir, 1920), Pericoma (Pericoma) pseudoexquisita Tonnoir, 1940 and Pneumia stammeri (Jung, 1956) in the past are first time confirmed as adults from Slovakia. Some detailed important morphological characters males of two selected species Pericoma (Pericoma) exquisita and P. (P.) pseudoexquisita are figured. All credible and available data of non-biting moth flies (Diptera: Psychodidae) from Slovakia were summarized (396 localities) and many new collecting sites (visited by different collectors from 1977 to 2013) added (188 localities). A suitable grid mapping for Central Europe was used. A preliminary conservation status of 51 rare species is discussed. The speciesrichness of the psychodid fauna in Slovakia is increased by this paper to 117 species.
Improvement on the Discrepancy of (t, e, s)-Sequences
Authors: Tezuka Shu 
Published: March 2015

Abstract
Recently, a notion of (t, e, s)-sequences in base b was introduced, where e = (e1, . . . , es) is a positive integer vector, and their discrepancy bounds were obtained based on the signed splitting method. In this paper, we first propose a general framework of (Tε , ε, s)-sequences, and present that it includes (T, s)-sequences and (t, e, s)-sequences as special cases. Next, we show that a careful analysis leads to an asymptotic improvement on the discrepancy bound of a (t, e, s)-sequence in an even base b. It follows that the constant in the leading term of the star discrepancy bound is given by
The Order of Appearance of the Product of Five Consecutive Lucas Numbers
Authors: Marques Diego , Trojovský Pavel 
Published: March 2015

Abstract
Let Fn be the nth Fibonacci number and let Ln be the nth Lucas number. The order of appearance z(n) of a natural number n is defined as the smallest natural number k such that n divides Fk. For instance, z(Fn) = n = z(Ln)/2 for all n > 2. In this paper, among other things, we prove that

for all positive integers n ≡ 0,8 (mod 12).
The Imagistic Theatre of Robert Whitman
Authors: Rottner Nadja 
Published: March 2015

ABSTRACT:This essay discusses the experimental theatre of Robert Whitman who, in 1960, turned toward performance with the sensibility of a process-oriented painter and sculptor. More specifically, it addresses the role that perception plays in both the creation and the reception of three of his less often studied performances: Architecture (1972), Northern Dark (1987), and, more recently, Passport (2011). As part of a larger intermedia trend in American art of the 1950s and early 1960s to create audio-visual “Happenings” that seek to “intensify” and “renew perceptual experience,” these postdramatic event-structures interweave film into complex imagistic sequences that are both felt and understood cognitively, live and mediated. In a discussion of the remedial intent implicit in Whitman’s theatre of vision, termed a “theatre of images” by Bonnie Maranca, the article relies on early American process philosophy to clarify the nature and the effects of embodied experience that these works seek to elicit.
A Postcolonial Reading of Lesia Ukraïnka’sOrhiia
Authors: Andrianova Anastassiya 
Published: March 2015

ABSTRACT:Lesia Ukraïnka’s Orhiia [The Orgy] (1913) is traditionally read as an anti-colonial allegory for Ukraine’s subjugation to Russia, an approach supported by Ukraine’s history and Ukraïnka’s biography. Such readings highlight the plight of the male hero, whose aesthetic ideals are inextricable from his loyalty to his nation. The aim of the present article is to offer a new interpretation that focuses, rather, on the marginal characters previously dismissed as “cultural renegades,” who aligned themselves with Russian culture. Grounded in postcolonial feminist theory, this close analysis reveals the tensions between national loyalty and sterile parochialism and between cosmopolitanism and aesthetic integrity. By placing Ukraïnka’s Orhiia in the Second-World context, the article invites further inquiry into Eastern- and Central-European modernist drama that re-enacts important aspects of these nations’ colonial experience, particularly the effects of the imperial male gaze on colonial women artists.
Adaptation, Fidelity, and the “Reek” of Aesthetic Ideology: Susan Sontag’s Lady from the Sea
Authors: Gunn Olivia Noble 
Published: March 2015

ABSTRACT: This article considers Susan Sontag’s adaptation of Henrik Ibsen’s The Lady from the Sea (1888). Both Ibsen and Sontag break faith with older traditions in order to keep faith with amended and contemporary versions of aesthetic truth. Sontag considered Ibsen’s play to be deeply flawed, but I argue that the flaws Sontag perceived arose, instead, from the conflict between her romantic-modernist ideology and Ibsen’s counter-romantic and realist drama. By pairing down Ibsen’s dense world in favour of symbolism, her play expresses a starker critique of bourgeois marriage; her mermaid is a symbol for a poetics of sexual difference that resists the possibility of woman’s happy adjustment to a patriarchal world. Ibsen, on the other hand, uses his mermaid to acknowledge the simultaneous power and hollowness of romantic symbols, indicating how they can overshadow other aesthetic interests – including the complex and neurotic, late-nineteenth-century bourgeois housewife.
Tooth brushing with and without Dentifrice - A Comparative Study
Authors: Pathak Liza 
Published: March 2015

Tooth brushing is such a familiar process that it is easy to forget how crucial it is to oral health and how important it is to brush properly. Twenty three patients were selected in the age-group of 30-40 having tooth brushing abrasion in the cervical region of at least three teeth and taught the Modified Stillmans Brushing Technique during a four week pre-test period. Plaque disclosing agent was used prior to and after brushing to educate the subjects .At the end of the pre-test period a complete oral prophylaxis was done to obtain a zero plaque score. The patient was asked to refrain from any oral hygiene procedure for next 48 hours and nonfibrous regular diet was advised. After 48 hours pre-brushing plaque scoring was recorded according to Turesky-Gilmore-Glickman Modification of the Quigley-Hein plaque index. A split mouth design was followed to record the post brushing plaque scores. Each time the patients were asked to brush on both upper and lower quadrants of one side for recording post-brushing plaque scores without dentifrice first and then brush on the upper and lower quadrants of the other side for recording plaque scores with dentifrice. The three treatment groups viz. Pre-brushing, Post-brushing without dentifrice and Post-brushing with dentifrice when subjected to ANOVA confirmed that the Modified Stillmans Technique effectively removes plaque in both post-brushing situations (p<0.01).The subjects showed a reduction in plaque levels in the Post-brushing trials as indicated by C.D. value (0.0179) (p<0.05). It can be derived from the statistical analysis that if properly done tooth brushing removes plaque effectively when used with or without dentifrice. DOI: http://dx.doi.org/10.3329/bjdre.v5i1.22451 Bangladesh Journal of Dental Research and Education Vol.5(1) 2015: 06-10
Oral Health Status among Drug Addicts in a Selected Hospital in Dhaka City
Authors: Mamun Md Abdullah Al , Kabir Md Jahangir , Farzan Md Sajedul Asif , Zerin Ishrat , Kabir Md Arafat , Uddin AKM Salah 
Published: March 2015

This was a cross-sectional study on oral health status of drug addicted patients admitted in a drug abuse treatment center in Dhaka city. This study was conducted at Mukti Mental Hospital, Drug & Alcohol Treatment Center situated at Gulshan, Dhaka, Bangladesh. The study was carried out among 50 drug addicts from the month of January to June 2012. Data were collected from the patients from 21st April to 5th May 2012. The main objective of the study was to assess and investigate the oral hygiene practice and oral health status of drug abusers. Fifty drug abusers irrespective of sex and age were interviewed & their oral health status was evaluated using the World Health Organization recommended procedures for Decayed, Missing, Filled teeth and the periodontal status. Data were collected with a pretested structured questionnaire and checklist. Dental caries was found in 92% of the drug addicts, while Missing and Filled teeth were recorded 86% and 88% of the addicts respectively. 86% of the addicts demonstrated DMFT score 1 or Higher; whereas 14% of the addicts demonstrated DMFT score 0 or were free from any form of dental decay, missing teeth or dental filling and 74% of the drug addicts had gingival inflammation and bleeding from gum, 42% had some oral mucosal lesion like apthus ulcer and candidiasis. The number of Decayed, Missing or Filled teeth increased with less frequency of daily tooth brushing and this finding was significant (p<0.01). On the basis of these findings it was concluded that dental caries in drug addicts is a major health concern and creating awareness among the public about harmful effects of drugs on their oral health through plan and policy can reduce the burden of dental diseases. Moreover mass media and general education of the mass people can play a vital role. DOI: http://dx.doi.org/10.3329/bjdre.v5i1.22452 Bangladesh Journal of Dental Research and Education Vol.5(1) 2015: 11-13
Evaluation of the diagnostic accuracy of four-view radiography and conventional computed tomography analysing sacral and pelvic fractures in dogs
Authors: Senthirajah S. K. J. , Nemanic S. , Baltzer W. , Warnock J. , Bobe G. , Stieger-Vanegas S. M. 
Published: March 2015

SummaryObjective: The purpose of our study was (1) to determine whether four-view radiography of the pelvis is as reliable and accurate as computed tomography (CT) in diagnosing sacral and pelvic fractures, in addition to coxofemoral and sacroiliac joint subluxation or luxation, and (2) to evaluate the effect of the amount of training in reading diagnostic imaging studies on the accuracy of diagnosing sacral and pelvic fractures in dogs.Methods: Sacral and pelvic fractures were created in 11 canine cadavers using a lateral impactor. In all cadavers, frog-legged ventrodorsal, lateral, right and left ventro-45°-medial to dorsolateral oblique frog leg (“rollover 45-degree view”) radiographs and a CT of the pelvis were obtained. Two radiologists, two surgeons and two veterinary students classified fractures using a confidence scale and noted the duration of evaluation for each imaging modality and case. The imaging results were compared to gross dissection.Results: All evaluators required significantly more time to analyse CT images compared to radiographic images. Sacral and pelvic fractures, specifically those of the sacral body, ischiatic table, and the pubic bone, were more accurately diagnosed using CT compared to radiography. Fractures of the acetabulum and iliac body were diagnosed with similar accuracy (at least 86%) using either modality.Clinical significance: Computed tomography is a better method for detecting canine sacral and some pelvic fractures compared to radiography. Computed tomography provided an accuracy of close to 100% in persons trained in evaluating CT images.
Formation des enseignants : les résistances au genre
Authors: Salle Muriel 
Published: March 2015

La mise en place du programme de l’ abcd de l’Egalité, en octobre 2013, dans un contexte de tension consécutif au vote de la loi sur le mariage dit « pour tous », a placé sur le devant de la scène médiatique des actions pédagogiques pour la promotion de l’égalité entre filles et garçons dans le système scolaire dont certaines sont pourtant déjà anciennes. Dans l’académie de Lyon, depuis plus de dix ans, les enseignants reçoivent une formation sur les problématiques de genre et d’égalité entre les sexes. Ces formations, globalement très bien accueillies, suscitent aussi parfois des résistances, en dépit du fait que les enseignants en sont très demandeurs d’une part, et qu’ils se déclarent très soucieux de promouvoir l’égalité filles/garçons et femmes/hommes d’autre part. C’est à l’analyse de ce paradoxe qu’est consacré cet article, qui veut proposer à la fois une typologie de ces résistances et des pistes de remédiation.
Emploi associatif, féminisme et genre
Authors: Flahault Érika , Dussuet Annie , Loiseau Dominique 
Published: March 2015

Le féminisme des années 1970 a débouché sur la création de réseaux associatifs aujourd’hui incontournables : Planning familial, Centres d’Information sur les Droits des Femmes et des Familles, Fédération Nationale Solidarité Femmes. Ces réseaux, producteurs d’un service de défense et d’accès aux droits pour les femmes, remplissent une fonction de « service public », grâce à l’emploi de salariés qui sont essentiellement des femmes. A partir des résultats d’une enquête qualitative de type monographique auprès d’associations de ces réseaux, nous montrerons que, si l’on peut observer dans ces organisations des conditions d’emploi souvent précaires, il faut sans doute référer ces observations aux conditions d’emploi que rencontrent par ailleurs les femmes dans d’autres secteurs de l’économie. Autrement dit, il semble que, paradoxalement, ces organisations féministes reproduisent simplement des normes d’emploi structurées par le genre.
Myeloid HIFs Are Dispensable for Resolution of Inflammation during Skeletal Muscle Regeneration
Authors: Gondin Julien , Théret Marine , Duhamel Guillaume , Pegan Katarina , Mathieu Jacques R. R. , Peyssonnaux Carole , Cuvellier Sylvain , Latroche Claire , Chazaud Bénédicte , Bendahan David , Mounier Rémi 
Published: March 2015

Abstract
Besides their role in cellular responses to hypoxia, hypoxia-inducible factors (HIFs) are involved in innate immunity and also have anti-inflammatory (M2) functions, such as resolution of inflammation preceding healing. Whereas the first steps of the inflammatory response are associated with proinflammatory (M1) macrophages (MPs), resolution of inflammation is associated with anti-inflammatory MPs exhibiting an M2 phenotype. This M1 to M2 sequence is observed during postinjury muscle regeneration, which provides an excellent paradigm to study the resolution of sterile inflammation. In this study, using in vitro and in vivo approaches in murine models, we demonstrated that deletion of hif1a or hif2a in MPs has no impact on the acquisition of an M2 phenotype. Furthermore, using a multiscale methodological approach, we showed that muscles did not require macrophagic hif1a or hif2a to regenerate. These results indicate that macrophagic HIFs do not play a crucial role during skeletal muscle regeneration induced by sterile tissue damage.
Electronic Health Records and Patient Safety
Authors: Gans D. , White J. , Nath R. , Pohl J. , Tanner C. 
Published: March 2015

SummaryBackground: The role of electronic health records (EHR) in enhancing patient safety, while substantiated in many studies, is still debated.Objective: This paper examines early EHR adopters in primary care to understand the extent to which EHR implementation is associated with the workflows, policies and practices that promote patient safety, as compared to practices with paper records. Early adoption is defined as those who were using EHR prior to implementation of the Meaningful Use program.Methods: We utilized the Physician Practice Patient Safety Assessment (PPPSA) to compare primary care practices with fully implemented EHR to those utilizing paper records. The PPPSA measures the extent of adoption of patient safety practices in the domains: medication management, handoffs and transition, personnel qualifications and competencies, practice management and culture, and patient communication.Results: Data from 209 primary care practices responding between 2006–2010 were included in the analysis: 117 practices used paper medical records and 92 used an EHR. Results showed that, within all domains, EHR settings showed significantly higher rates of having workflows, policies and practices that promote patient safety than paper record settings. While these results were expected in the area of medication management, EHR use was also associated with adoption of patient safety practices in areas in which the researchers had no a priori expectations of association.Conclusions: Sociotechnical models of EHR use point to complex interactions between technology and other aspects of the environment related to human resources, workflow, policy, culture, among others. This study identifies that among primary care practices in the national PPPSA database, having an EHR was strongly empirically associated with the workflow, policy, communication and cultural practices recommended for safe patient care in ambulatory settings.Citation: Tanner C, Gans D, White J, Nath R, Pohl J. Electronic health records and patient safety – co-occurrence of early EHR implementation with patient safety practices in primary care settings. Appl Clin Inf 2015; 6: 136–147http://dx.doi.org/10.4338/ACI-2014-11-RA-0099