bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oleandrin enhances radiotherapy sensitivity in lung cancer by inhibiting the ATM/ATR‐mediated DNA damage response
Authors: Wu Qiong , Liu Xue , Wang Li‐min , Yang Yu‐hong , Pan Li‐fang , Zhang Jing‐jing , Wang Yu‐qing , Yao Qing‐hua , Ma Sheng‐lin , Zhang Shi‐rong 
Published: June 2024

AbstractDespite active clinical trials on the use of Oleandrin alone or in combination with other drugs for the treatment of solid tumors, the potential synergistic effect of Oleandrin with radiotherapy remains unknown. This study reveals a new mechanism by which Oleandrin targets ATM and ATR kinase‐mediated radiosensitization in lung cancer. Various assays, including clonogenic, Comet, immunofluorescence staining, apoptosis and Cell cycle assays, were conducted to evaluate the impact of oleandrin on radiation‐induced double‐strand break repair and cell cycle distribution. Western blot analysis was utilized to investigate alterations in signal transduction pathways related to double‐strand break repair. The efficacy and toxicity of the combined therapy were assessed in a preclinical xenotransplantation model. Functionally, Oleandrin weakens the DNA damage repair ability and enhances the radiation sensitivity of lung cells. Mechanistically, Oleandrin inhibits ATM and ATR kinase activities, blocking the transmission of ATM‐CHK2 and ATR‐CHK1 cell cycle checkpoint signaling axes. This accelerates the passage of tumor cells through the G2 phase after radiotherapy, substantially facilitating the rapid entry of large numbers of inadequately repaired cells into mitosis and ultimately triggering mitotic catastrophe. The combined treatment of Oleandrin and radiotherapy demonstrated superior inhibition of tumor proliferation compared to either treatment alone. Our findings highlight Oleandrin as a novel and effective inhibitor of ATM and ATR kinase, offering new possibilities for the development of clinical radiosensitizing adjuvants.
Risk Factors of Smartphone Addiction: A Systematic Review of Longitudinal Studies
Authors: Crowhurst Sina , Hosseinzadeh Hassan 
Published: June 2024

ABSTRACTBackgroundSmartphone addiction is exponentially increasing worldwide. It has negative health consequences. Previous systematic reviews identified several risk factors of smartphone addiction; however, they were based on cross‐sectional data. This systematic review aimed to fill the gap by assessing smartphone addiction risk factors using longitudinal studies.MethodsThis systematic review is registered with PROSPERO (CRD42023431529) and followed the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. Six databases, including Scopus, Medline, Web of Science, PubMed, ProQuest Central and PsycINFO, were searched to identify eligible studies. Studies were eligible if they assessed smartphone addiction as the outcome variable, were longitudinal and were published in English. All papers included in this review were assessed for the risk of bias and quality.ResultsA total of 22 papers met the inclusion and exclusion criteria after the screening process. The results were categorised into three groups, including personal, social and environmental factors. Within the groups, seven risk factors, including mental health, emotions, academic stress, social rejection and peer victimisation as well as family dysfunction and parental phubbing, were identified. All of the risk factors were significant predictors of smartphone addiction. Mental health problems, social rejection and peer victimisation also displayed a bidirectional relationship with smartphone addiction. Inconsistent smartphone addiction measurements were used.ConclusionThis review has significant implications for policymakers as it identified seven risk factors for smartphone addiction. Further studies are warranted to improve the understanding of the aetiology of smartphone addiction and inform education, counselling and coping with smartphone addiction.
Bioactive Calcium Hydride‐Driving “Triple” Hydrogen/Alkaline/Calcium Therapy for Efficient Treatment of Osteomyelitis
Authors: Chen Lin , Cheng Shuning , Lu Shunyi , Gao Xiang , Gong Fei , Shi Junwu , Han Zhihui , Wang Yuanjie , Yang Xiaoyuan , Zhou Xiaozhong , Cheng Liang 
Published: June 2024

AbstractOsteomyelitis with high mortality and disability rates is a common clinical disease caused by a bacterial infection that is difficult to cure. Considering the stubborn nature and depth of tissue infection, rapid and effective treatments for osteomyelitis remain an enormous challenge. Calcium hydride (CaH2), as efficient hydrogen/alkaline/calcium donors, is employed for combined osteomyelitis therapy. CaH2 reacts with water to sufficiently generate a strong alkali environment with hydroxide anions (OH−) to inhibit bacterial proliferation and induce bacterial death. The released calcium ions (Ca2+) induce calcium overload to kill bacteria first and then serves as calcium source to promote new bone formation. Another byproduct, hydrogen enhances the bacterial membrane permeability and scavenges excess reactive oxygen species (ROS). After incubation with bacteria, CaH2 significantly increases the permeability of the bacterial membrane, therefore increasing the entry of OH− and Ca2+ into bacterial cells, thereby leading to significant bacterial death. After being applied to S. aureus‐infected mouse tibia osteomyelitis, CaH2 materials efficiently kill bacteria, relieve local inflammation, and promote new bone formation in a short time. Overall, bioactive metal hydride‐associated “triple” hydrogen/alkaline/calcium therapy provides a new idea for the treatment of deep‐site bacterial infection, which is beneficial for relieving the pressure caused by antibiotic‐resistant bacteria.
Symmetrically Fluorinated D‐π‐A Structured Cyanine Dye for Highly Efficient NIR‐II Imaging‐Guided Cancer Phototheranostics
Authors: Hassan Muhammad , Su Yi Tan , Iqbal Sania Zafar , Nawaz Raziq , Wang Yucai , Jiang Wei 
Published: June 2024

AbstractNear‐infrared‐II (NIR‐II) fluorescence imaging‐guided photothermal therapy (PTT) represents a cutting‐edge approach for precise tumor diagnosis and treatment, providing real‐time therapeutic efficacy evaluation. However, a significant challenge lies in the creation of phototheranostic agents that provide robust imaging and efficient photothermal conversion. To address this, a donor‐π‐acceptor (D‐π‐A) structure heptamethine cyanine derivative, IR1116, that confers a strong intramolecular charge transfer effect is developed. To enhance its applicability, IR1116 is formulated with DSPE‐PEG to create a water‐dispersible NIR‐II phototheranostic nanoheater, NPIR1116. This nanoheater benefits from the incorporation of an electron‐withdrawing group, leading to reduced photooxidation activity and significantly improved photostability. NPIR1116 exhibits strong NIR‐II absorption and fluorescence, peaking at 1004 and 1116 nm, respectively, as well as a photothermal conversion efficiency of 79% under 1064 nm lasers. In vitro and in vivo studies showed the efficacy of NPIR1116 in tumor imaging via NIR‐II fluorescence and its ability to effectively induce tumor cell apoptosis under 1064 nm laser irradiation. These findings underscore the potential of NPIR1116 in NIR‐II fluorescence imaging‐guided PTT for tumor treatment, paving the way for further advancements in NIR‐II dye development and bioimaging technologies.
Modulation of Charge Redistribution in Heterogeneous CoSe‐Ni0.95Se Coupling with Ti3C2Tx MXene for Hydrazine‐Assisted Water Splitting
Authors: Feng Zhongbao , Meng Haoyu , Fu Yumo , Ren Lili , Gao Bo , Liu Wentao 
Published: June 2024

AbstractIntegrating abundant dual sites of hydrazine oxidation reaction (HzOR) and hydrogen evolution reaction (HER) into one catalyst is extremely urgent toward energy‐saving H2 production. Herein, CoSe‐Ni0.95Se heterostructure coupling with Ti3C2Tx MXene (CoSe‐Ni0.95Se/MXene) is fabricated on nickel foam (NF) to enhance the catalytic performance. The heterogeneous CoSe‐Ni0.95Se and MXene coupling effect can change the coordination of Ni and Co, resulting in adjusted interfacial electronic field and enhanced electron transfer from Ni0.95Se to CoSe especially near MXene surface. Also, the appearance of MXene can anchor more active sites, thereby abundant nucleophilic CoSe and electrophilic Ni0.95Se are formed induced by the charge redistribution, which can tailor d‐band center, moderate *H adsorption free energy (∆GH*) and facilitate adsorption/desorption for hydrazine intermediates, contributing to much enhanced HER and HzOR performance. For example, the low potentials of −160.8 and 116.1 mV at 400 mA cm−2 are seen for HER and HzOR with long‐term stability of 7 days. When assembled as overall hydrazine splitting (OHzS), a small cell voltage of 0.35 V to drive 100 mA cm−2 is obtained. Such concept of integrating abundant nucleophilic and electrophilic dual sites and regulating their d‐band centers can offer in‐depth understandings to design efficient bifunctional HER and HzOR electrocatalysts.
Pre‐Corrosion of Zinc Metal Anodes for Enhanced Stability and Kinetics
Authors: Cao Jin , Wang Xu , Zhang Dongdong , Luo Ding , Zhang Lulu , Qin Jiaqian , Zhang Xinyu , Yang Xuelin 
Published: June 2024

AbstractNon‐uniform zinc plating/stripping in aqueous zinc‐ion batteries (ZIBs) often leads to dendrites formation and low Coulombic efficiency (CE), limiting their large‐scale application. In this study, a pre‐corroded Zn (PC‐Zn) anode with 3D ridge‐like structure is constructed by a facile solution etching in sodium hypophosphite (NaH2PO2) solution. The surface preparation process can significantly remove impurities from the passivation layer of bare Zn anode, thus exposing a great quantity of active sites for easy plating/stripping. Moreover, the pre‐corroded structure enables a uniform‐distributed electric field to promote the 3D Zn2+ diffusion process and accelerate the transfer kinetics, thereby suppressing the zinc dendrites and interfacial side reactions. Consequently, symmetric cells with PC‐Zn electrodes demonstrate remarkable stability, maintaining cycles for over 3200 h under 1 mA cm−2. The PC‐Zn/VO2 full cell maintains a specific capacity of 361 mAh g−1 at 0.1 A g−1, and a capacity retention rate of ≈80% over 1000 cycles at 4 A g−1. Notably, no obvious dendrites and side reactions are detected after extended cycling. Leveraging the cost‐effectiveness, environmentally friendly nature, and easy fabrication of the PC‐Zn electrode, this Zn protection strategy holds promise for advancing the industrial application of ZIBs.
A Universal Strategy for Constructing Hydrogel Assemblies Enabled by PAA Hydrogel Adhesive
Authors: Li Qingyun , Quan Xinyi , Hu Rui , Hu Ziqing , Xu Shaoyu , Liu Hui , Zhou Xiaohe , Han Bin , Ji Xiaofan 
Published: June 2024

AbstractHydrogel is a significant type of building block for constructing macroscopic assemblies, the construction of which usually entails the incorporation of supramolecular groups. However, supramolecular group recognition is specific and only suitable for assembling two particular modified hydrogels, but not a versatile strategy. Herein, a universal strategy without modification process is proposed using polyacrylic acid (PAA) hydrogel as the adhesive layer to assemble different kinds of hydrogels. Furthermore, hydrogel assemblies with various shapes and multi‐stimuli responsiveness are constructed by assembling different stimuli‐responsive hydrogels with PAA hydrogel. Therefore, hydrogel assemblies are able to complete bending motions upon applying corresponding stimuli. This strategy provides a universal approach for constructing hydrogel assemblies, and also shows the potential for developing soft robots with versatile functions.
Exploring AI models and applications within a system framework
Authors: Sun Yu , Li Ling , Yu Zhaoyuan , Yu Haiqing , Wang Hecheng 
Published: June 2024

AbstractArtificial intelligence (AI) has emerged as a pivotal catalyst for industrial advancement and economic growth, fueling innovation across various sectors. It stands as a cornerstone in propelling the integrated evolution of cutting‐edge technologies like big data, cloud computing, blockchain, 5G/6G and industry 4.0. Consequently, AI has captured significant attention within academic and industrial spheres alike. This study conducts a comprehensive review of AI‐related research and models, offering systematic insights into its industrial applications and future trajectories. By providing valuable insights, this review serves as a crucial reference point for both researchers and practitioners navigating the dynamic landscape of AI innovation.
Using concept mapping to identify recruitment and engagement strategies for inclusion of LGBTQIA+ populations in Alzheimer's disease and related dementia research
Authors: Klenczar‐Castro Brittany , Kittle Krystal R. , Anderson Joel G. , Wharton Whitney , Gilmore‐Bykovskyi Andrea , Dowling N. Maritza , Perales‐Puchalt Jaime , Flatt Jason D. 
Published: June 2024

AbstractINTRODUCTIONPast Alzheimer's disease and related dementias (ADRD) research has not considered ways to ensure the representation of diverse sexual and gender minorities. This study used concept mapping (CM) to identify strategies for engaging and recruiting LGBTQIA+ older adults living with memory loss and their caregivers into ADRD research.METHODSCM, involving brainstorming, thematic analysis, and rating of strategies, was conducted with 46 members from one national and three local community advisory boards. Data was analyzed using The Concept Systems Global MAX™ web platform.RESULTSOne hundred twenty‐two solutions were identified from June through December 2022, and represented five key themes: aging focused, LGBTQIA+ specific, memory loss and caregiving support focused, physical advertisements, and other media. Promising strategies included partnering with LGBTQIA+ health centers, attending social groups for older adults, and increasing community representation in marketing.DISCUSSIONTailored strategies, building trust, and community involvement are essential for engaging LGBTQIA+ individuals living with memory loss or ADRD and their caregivers in ADRD‐focused research.Highlights
Innovative ways to ensure the inclusion of LGBTQIA+ older adults in Alzheimer's disease and related dementias (ADRD) research can be bolstered through collaboration with key community stakeholders.
Promising strategies for recruitment and engagement include partnering with LGBTQIA+ centers, attending social groups for older adults, and ensuring diverse representation in marketing.
Tailored recruitment and engagement strategies are crucial for building trust with LGBTQIA+ populations to increase participation in ADRD research.
Tracking Tourist Flows Through Wi-Fi Sensor Technology in Seville
Authors: Franco Irene N. , Foronda-Robles Concepción , Rollán Federico , Canales Pino 
Published: June 2024

AbstractThe study of tourism flows consists of understanding the spatial-temporal relationship of tourists with the space they visit, which has become a key aspect for the management of destinations. The advance of communication and information technologies nowadays allows the extraction and storage of a large amount of data of different types and at different scales, which can be very useful for decision-making. In this context, this study aims to use WiFi sensor technology to track and record the movement patterns of tourists. The methodology used focuses on the measurement and analysis of this variable through the extraction of real-time data from WiFi points in the Barrio de Santa Cruz, Seville. The results obtained demonstrate the viability of this instrument for analysing tourist flows at the destination as opposed to the use of other instruments that involve higher costs and/or limitations. Likewise, in terms of its applicability, the results show the need for its use, in combination with other tools and techniques, for the planning and management of tourist destinations.
It Takes a Whole School: An Introduction
Authors: Wals Arjen E. J. , Eikeland Ingrid , Bjønness Birgitte , Sinnes Astrid 
Published: June 2024

AbstractFor the last 40–50 years researchers and policymakers have been writing alarming texts pointing at the dismal state people and the entire planet Earth are in. Since then, a growing group of environmental and science educators have worked tirelessly and determinedly towards promoting an education that engages young people in environmental issues, connect them to nature and the outdoors, and even make them more ‘action competent’. Still, arguably, not much progress has been made in developing a more sustainable world. By and large, education has not yet found a way to enrich, engage and empower young people. Rather than optimizing conventional ways of teaching and learning by adding on or even integrating sustainability related topics, this book explores an integrated Whole School Approach as a potentially deep and meaningful response from education to help young people in addressing the grand sustainability challenges of our time. This opening chapter provides an introduction to the book.
Piloting a Self-Assessment Tool for a Whole School Approach to Sustainability in Mongolia
Authors: Shinetsetseg Erdenebayar , Battsetseg Genendorj , Oyuntungalag Orsoo , Temuujin Lundaajantsan , Goswami Mita Nangia 
Published: June 2024

AbstractThis chapter attempts to demonstrate to the readers how Mongolian schools have been introduced to the concept of the Whole School Approach under Education for Sustainable Development pillars within the framework of the financial assistance from the donor-funded project on ESD promotion.It presents the lessons learned and challenges encountered in this pilot program, which may interest the further strengthening of this approach in school management and planning.
Students’ Deliberation on ‘Greening’ the School’s Energy Supply: A Case Discussed from a Whole School Approach Perspective
Authors: Mathisen Øyvind , Johansen Gerd 
Published: June 2024

AbstractDeliberative communication can be one way of creating a school culture that supports WSA for sustainability. This chapter is based on a design-based research project that investigates students’ deliberative communication when they work with an inquiry project. The project aimed at enabling ‘green transitions’ by inquiring the school’s energy system and thus strengthening the students’ technology awareness. While handling technology as part of education for sustainable development (ESD), the students are given the opportunity to deliberate through argumentation, listening to and respecting each other as well as reaching consensus about energy technology. The student groups were given a commission by the county municipality to make the school more sustainable regarding energy sources and energy use. The students handed in their proposals to the headmaster. We argue that deliberative communication initiated by inquiry projects concerning technology that focuses on ‘green transitions’ plays a part in supporting schools to become more sustainable.
Exploring a Whole-School Approach at Nonformal Folk High Schools in Norway Through Common Goals and Action Learning
Authors: Phuthi Brita 
Published: June 2024

AbstractOver the last 9 years, the Norwegian Folk High Schools (FHSs) have engaged in implementation of the Sustainable Development Goals (SDGs) through common projects focusing on the school’s operation and teaching. This chapter critically analyses and reflects on two collective FHS initiatives the FHSs have engaged in. To consider the challenges and opportunities of the schools’ sustainability processes, a Whole-School Approach (WSA) flower model by Wals and Mathie (Whole School responses to climate urgency and related sustainability challenges. In: Peters MA, Heraud R (eds) Encyclopedia of educational innovation. Springer. https://doi.org/10.1007/978-981-13-2262-4_263-1, 2022) is employed as an analytical lens. The chapter finds that the FHS pedagogy engages with all six elements of the flower model and when the FHS pedagogy is practiced, it provides living examples of learning sites practicing a WSA to sustainability. The FHSs participating in joint sustainability initiatives, seeing that neighboring schools also make changes, reinforce that the community and common goals of the FHSs matter. The chapter concludes that the FHSs WSA to learning is an ongoing process, involving dialogue and fostering democratic confidence.
A Whole-School Approach to Building Communities of Practice of ESD: A Case Study of Two Japanese High Schools
Authors: Shibakawa Hiroko 
Published: June 2024

AbstractThe study aims to elucidate the structure and requirements of educational strategies that foster Communities of Practice (CoP) for Education for Sustainable Development (ESD). It examines two Japanese high schools that are implementing ESD through a ‘Period of Integrated Studies’. Both schools are located in depopulating mountain areas and are facing closure due to youth migration. High School A redesigned its learning project to prioritise ESD, while High School B initiated ESD as a volunteer project by teachers and introduced an original ‘environment’ subject. The study analyses the transformation of their practices and CoP formations. It highlights the challenges: maintaining the transformative aspect of ESD, adapting to uncertainty, fostering critical perspectives, involving stakeholders and maintaining a consistent approach. Despite the difficulties of local-global linkages, a different perception of practice ‘failure’ proves to be significant. In this chapter, requirements for the establishment of CoPs were outlined, emphasising the interconnectedness of formal, non-formal and information education in a Whole-School Approaches to ESD.
Inferences from Statistics to Causation
Authors: Johansson Lars-Göran , Banitz Thomas , Grimm Volker , Hertz Tilman , Lindkvist Emilie , Martínez Peña Rodrigo , Radosavljevic Sonja , Ylikoski Petri , Schlüter Maja 
Published: June 2024

AbstractEmpirical results often consist of data organised as values of variables.The first question is whether an observed correlation is evidence enough for a correlation in the entire population. If the answer is yes, the next question is whether this correlation reflects a causal connection or not. That need not be the case, there might be a common cause. The main points of this chapter are:

A correlation in an observed sample may not reflect any correlation in the entire population.

There are three possible explanations for a correlation in a population: variable X is one cause of Y, or vice versa, or they have a common cause.

The most reliable way to decide which is the case is to perform experiments.

If experiments are impossible one can sometimes infer a causal relation from a natural experiment.
Causation in Social-Ecological Systems Research
Authors: Johansson Lars-Göran , Banitz Thomas , Grimm Volker , Hertz Tilman , Lindkvist Emilie , Martínez Peña Rodrigo , Radosavljevic Sonja , Ylikoski Petri , Schlüter Maja 
Published: June 2024

AbstractThe book has so far introduced fundamental ideas about causation, i.e., the relation between cause and effect, from philosophy, particularly those ideas that underlie studies of causation based on quantitative data and statistical methods of causal inference (Chaps. 1–7). Knowledge of these concepts, ideas and associated methods is essential as they are often used in sustainability science studies rooted in the natural sciences, economics and other quantitative social sciences. The book has also introduced the notions of causal explanation and causal mechanisms, which are used more broadly in both quantitative and qualitative studies to explain how a cause brings about an effect (Chap. 8). In this last chapter we want to reflect on causal reasoning from a broader angle, to illustrate the diversity of ways in which sustainability researchers reason about causation, and to highlight the many instances within a research process in which researchers engage in causal reasoning.