bluuebunny/crossref_metadata_2025_split huggingface dataset:
From the latin “re-cordis, passing through the heart”: autonomic modulation differentiates migraineurs from controls when recounting a significant life event
Authors: Guidotti Sara , Torelli Paola , Ambiveri Giordano , Fiduccia Alice , Castaldo Matteo , Pruneti Carlo 
Published: August 2024

Abstract
Objective
The literature on clinical psychophysiology highlights the possibility of using Heart Rate Variability (HRV) as an index of psychophysical balance and resilience to stress. This study investigates the differences in stress reactivity and subsequent recovery between a group of migraineurs and healthy controls.

Methods
Socio-demographic (i.e., sex, age, profession, marital status, and level of education) and psychophysiological (HR and HRV) measures of a group of thirty subjects with migraine (26 migraineurs without aura (86.7%), 2 migraineurs with aura (6.7%), and 2 migraineurs with and without aura (6.7%)) and from thirty healthy control subjects were collected. In particular, HRV was analyzed through frequency-domain parameters, including Low-Frequency (LF; 0.04–0.15 Hz) and High-Frequency (HF; 0.15–0.4 Hz) bands as well as LF/HF ratio during a Psychophysiological Stress Profile (PSP) structured in seven phases: (1) Baseline, (2) Objective stressor 1 (Stroop Test), (3) Rest 1, (4) Objective stressor 2 (Mental Arithmetic Task), (5) Rest 2, (6) Subjective stressor (recount a significant life event), and (7) Rest 3. The LF, HF, and LF/HF ratio values were transformed into a logarithmic scale (i.e., log-LF, log-HF, and log LF/HF ratio). Additionally, LF and HF were converted into normalized units (0-100) (i.e., LF% and HF%) which, in turn, were used to obtain reactivity and recovery to stress through delta values (Δ) calculation.

Results
Subjects with migraine reported greater ΔLF% levels of reactivity and recovery to subjective stressor, demonstrating a prevalence of sympathetic activity while recounting a personal life event. At the same time, a lowering of the same values was found in the subjects of the group control.

Discussion
Our results underline the importance of conducting a psychophysiological assessment in patients with headaches because reduced stress management skills could influence the clinical manifestations of the disease, considering stress as one of the most common triggers for migraine patients.
A phase 2 study of mobocertinib as first-line treatment in Japanese patients with non-small cell lung cancer harboring EGFR exon 20 insertion mutations
Authors: Yoh Kiyotaka , Azuma Koichi , Hayashi Hidetoshi , Nishio Makoto , Chikamori Kenichi , Ichihara Eiki , Watanabe Yasutaka , Asato Takayuki , Kitagawa Tadayuki , Fram Robert J. , Ohe Yuichiro 
Published: August 2024

Abstract
Background
Mobocertinib is a novel, synthetic, orally administered tyrosine kinase inhibitor that inhibits many activated forms of epidermal growth factor receptor (EGFR), including those containing exon 20 insertion (ex20ins) mutations. This study aimed to assess the efficacy of mobocertinib in Japanese patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring EGFR ex20ins mutations.

Methods
This was a phase 2, open-label study. Patients with NSCLC harboring EGFR ex20ins mutations who had not had previous systemic treatment received mobocertinib 160 mg once daily. The primary endpoint was the confirmed objective response rate. A planned interim analysis was completed for the first 14 patients with a centrally confirmed EGFR ex20ins mutation, with enrollment stopped if the number of patients with an objective response was five or fewer.

Results
In total, 33 patients were enrolled into the study (63.6% women; median age: 66 years). At the interim analysis, the objective response rate evaluated by a central independent review committee was 28.6% (4/14, 90% confidence interval: 10.4–54.0); therefore, enrollment was stopped for futility. In the full analysis set, the objective response rate was 18.2% (6/33, 95% confidence interval: 7.0–35.5); of the six responders, one patient (3.0%) had a complete response and five patients (15.2%) had partial responses. The most common treatment-related adverse events were diarrhea, paronychia, stomatitis, and nausea.

Conclusion
Although study enrollment was terminated early owing to futility, our results showed modest activity of mobocertinib in Japanese patients with NSCLC with EGFR ex20ins mutations with no additional safety concerns.
Cost effectiveness of a GP delivered medication review to reduce polypharmacy and potentially inappropriate prescribing in older patients with multimorbidity in Irish primary care: the SPPiRE cluster randomised controlled trial
Authors: Gillespie Paddy , Moriarty Frank , Smith Susan M. , Hobbins Anna , Walsh Sharon , Clyne Barbara , Boland Fiona , McEnteggart Tara , Flood Michelle , Wallace Emma , McCarthy Caroline ,   for the SPPiRE Study team
Published: August 2024

Abstract
Background
Evidence on the cost effectiveness of deprescribing in multimorbidity is limited.

Objective
To investigate the cost effectiveness of a general practitioner (GP) delivered, individualised medication review to reduce polypharmacy and potentially inappropriate prescribing in older patients with multimorbidity in Irish primary care.

Methods
Within trial economic evaluation, from a healthcare perspective and based on a cluster randomised controlled trial with a 6 month follow up and 403 patients (208 Intervention and 195 Control) recruited between April 2017 and December 2019. Intervention GPs used the SPPiRE website which contained educational materials and a template to support a web-based individualised medication review. Control GPs delivered usual care. Incremental costs, quality adjusted life years (QALYs) generated using the EQ-5D-5L instrument, and expected cost effectiveness were estimated using multilevel modelling and multiple imputation techniques. Uncertainty was explored using parametric, deterministic and probabilistic methods.

Results
On average, the SPPiRE intervention was dominant over usual care, with non-statistically significant mean cost savings of €410 (95% confidence interval (CI): − 2211, 1409) and mean health gains of 0.014 QALYs (95% CI − 0.011, 0.039). At cost effectiveness threshold values of €20,000 and €45,000 per QALY, the probability of SPPiRE being cost effective was 0.993 and 0.988. Results were sensitive to missing data and data collection period.

Conclusions
The study observed a pattern towards dominance for the SPPiRE intervention, with high expected cost effectiveness. Notably, observed differences in costs and outcomes were consistent with chance, and missing data and related uncertainty was non trivial. The cost effectiveness evidence may be considered promising but equivocal.

Trial registration
ISRCTN: 12752680, 20th October 2016.
Skill intensity in manufacturing exports: Do basic, technology-intensive or differentiated exports cause growth in Kuwait?
Authors: Kalaitzi Athanasia Stylianou 
Published: August 2024

AbstractThis study examines the causality between basic, technology-intensive, and differentiated manufacturing exports and economic growth in Kuwait using data from 1970 to 2021 and two augmented production function models: one with natural resource exports (Model 1) and the other without on both sides of the model (Model 2). The Johansen cointegration and the autoregressive distributed lag model (ARDL) bound tests are conducted to examine the long-run relationship between the variables. In addition, the Granger causality test in a vector autoregressive framework (VAR) and the Toda–Yamamoto test are employed to explore the directions of the short- and long-run causality between variables, respectively. The empirical results of Model 1 indicate that neither of the decomposed manufacturing exports directly causes economic growth in the short or long run at any conventional significance level, whereas natural resource exports cause economic growth, basic and technology-intensive manufactured exports in the short-run at the 5% level. Model 2 estimations confirm the absence of direct causality between decomposed manufacturing exports and economic growth, whereas a long-run causality runs from output net of natural resource exports to basic manufactured exports at the 10% level. Both model estimations indicate that all the variables jointly cause economic growth and basic manufactured exports in the short and long run, directly or indirectly through imports, confirming the existence of a circular causation. These findings can serve as the basis for designing specific export–import policies to foster diversification and a sustainable economic growth in line with Kuwait’s Vision 2035.
Cutoff Ergodicity Bounds in Wasserstein Distance for a Viscous Energy Shell Model with Lévy Noise
Authors: Barrera G. , Högele M. A. , Pardo J. C. , Pavlyukevich I. 
Published: August 2024

AbstractThis article establishes explicit non-asymptotic ergodic bounds in the renormalized Wasserstein–Kantorovich–Rubinstein (WKR) distance for a viscous energy shell lattice model of turbulence with random energy injection. The system under consideration is driven either by a Brownian motion, a symmetric $$\alpha $$
α
-stable Lévy process, a stationary Gaussian or $$\alpha $$
α
-stable Ornstein–Uhlenbeck process, or by a general Lévy process with second moments. The obtained non-asymptotic bounds establish asymptotically abrupt thermalization. The analysis is based on the explicit representation of the solution of the system in terms of convolutions of Bessel functions.
Infinite-Volume Gibbs States of the Generalized Mean-Field Orthoplicial Model
Authors: Koskinen Kalle 
Published: August 2024

AbstractThe generalized mean-field orthoplicial model is a mean-field model on a space of continuous spins on $$\mathbb {R}^n$$

R

n

that are constrained to a scaled $$(n-1)$$

(
n
-
1
)

-dimensional $$\ell _1$$

ℓ
1

-sphere, equivalently a scaled $$(n-1)$$

(
n
-
1
)

-dimensional orthoplex, and interact through a general interaction function. The finite-volume Gibbs states of this model correspond to singular probability measures. In this paper, we use probabilistic methods to rigorously classify the infinite-volume Gibbs states of this model, and we show that they are convex combinations of product states. The predominant methods utilize the theory of large deviations, relative entropy, and equivalence of ensembles, and the key technical tools utilize exact integral representations of certain partition functions and locally uniform estimates of expectations of certain local observables.
Lime reactivity and overburning: the case of limestones belonging to Tuscan Nappe sequence (NW Tuscany, Italy)
Authors: Lezzerini Marco , Cinzi Luca , Pagnotta Stefano 
Published: August 2024

AbstractThis study examines limestone properties and calcination process to enhance product quality. Limestone burning produces lime (CaO, calcium oxide) and carbon dioxide (CO2). Lime is a substance highly reactive and turns into slaked lime (Ca(OH)2, calcium hydroxide) when exposed to water. Six limestone samples from Tuscan Nappe sedimentary sequence, outcropping in the Monti d’Oltre Serchio area (NW Tuscany, Italy), were selected and calcined at different temperatures (800, 900, 1000 and 1100 °C). The obtained lime was slaked, and chemical, mineralogical and petrographic analyses were conducted to study its reactivity during slaking process. Key factors influencing lime reactivity were identified: calcination temperature/time and limestone characteristics (chemical and mineralogical composition). The lime reactivity was measured through the rate of lime hydration reaction. Results showed that higher reactivity in lime, lower calcination temperature. The increase in temperature and time leads to an increase of CaO grain size and, consequently, to a decrease in reactivity. Temperature increase has a more significant effect on the increasing of grain size and reactivity than time. The optimal calcination temperature was found to be 900 °C, like that of ancient limekilns. The study emphasized the close link between lime reactivity and chemistry/mineralogy of limestone. Overall, the research provides insights for improving limestone calcination processes and obtaining superior products.
Diachronicity Matters! How Semantics Supports Discontinuism About Remembering and Imagining
Authors: Liefke Kristina , Werning Markus 
Published: August 2024

AbstractMuch work in philosophy, psychology, and neuroscience has argued for continuism about remembering and imagining (see, e.g., Addis J R Soc N Z 48(2–3):64–88, 2018). This view claims that episodic remembering is just a form of imagining, such that memory does not have a privileged status over other forms of episodic simulation (esp. imagination). Large parts of contemporary philosophy of memory support continuism. This even holds for work in semantics and the philosophy of language, which has pointed out substantial similarities in the distribution of the verbs remember and imagine. Our paper argues against the continuist claim, by focusing on a previously neglected source of evidence for discontinuism: the semantics of episodic memory and imagination reports. We argue that, in contrast to imagination reports, episodic memory reports are essentially diachronic, in the sense that their truth requires a foregoing reference-fixing experience. In this respect, they differ from reports of experiential imagination, which is paradigmatically synchronic. To defend our claim about this difference in diachronicity, we study the truth-conditions of episodic memory and imagination reports. We develop a semantics for episodic uses of remember and imagine that captures this difference.
Gait Speed Reserve in the general population-based ‘Good Aging in Skåne’ cohort study—distribution and associated factors
Authors: Lindholm Beata , Basna Rani , Ekström Henrik , Elmståhl Sölve , Siennicki-Lantz Arkadiusz 
Published: August 2024

AbstractGait Speed Reserve (GSR) expresses a difference between fast and comfortable gait speed and may have an impact on everyday functioning. It was also hypothesized as a useful proxy measure of physiological reserve. However, height-normalizing values of GSR and its associated factors have not been evaluated in a general population of older adults. Therefore, we aimed to investigate the distribution of height-normalized GSR (HN-GSR) in an elderly population-based cohort from urban and rural areas (n = 4342) aged 60–93 years and evaluate associated physiological and lifestyle factors. Using linear mixed models, we identified gender and nine modifiable factors as significantly associated with HN-GSR across four age groups. Better handgrip strength, cognition and standing balance, higher physical activity level, larger calf circumference, and less smoking had positive associations with HN-GSR, while female gender, more leg pain, higher weight and, alcohol consumption had opposite effects. The Marginal R2 imply that this model explained 26% of the variance in HN-GSR. Physical activity and handgrip strength varied across age groups in impact on HN-GSR. The differences were however comparatively minor. In this large cohort study of older adults, we proposed for the first time that factors associated with HN-GSR represented multi-domain features that are in line with previous findings reported for GSR. Measuring HN-GSR/GSR may help clinicians identify early physiological impairments or unhealthy lifestyle habits, especially among older women, and may also have safety implications in daily life. Further work is needed to find out if measuring HN-GSR/GSR may be useful in identifying adverse health outcomes and overall physiological reserve.
Sleep onset time as a mediator in the association between screen exposure and aging: a cross-sectional study
Authors: Lin Senlin , Gao Meng , Zhang Juzhao , Wu Yuting , Yu Tao , Peng Yajun , Jia Yingnan , Zou Haidong , Lu Lina , Li Deshang , Ma Yingyan 
Published: August 2024

AbstractExcessive screen exposure has become a significant health concern. This study investigates the impact of screen time on aging in middle-aged and elderly populations. Healthy working adults over 45 years old in Shanghai, China, underwent general and ocular examinations. Questionnaires collected demographics, medical history, and screen exposure details. Aging was assessed using the retinal age gap, defined as the difference between the retinal age predicted by deep learning algorithms based on fundus images and chronological age. Pathway analysis tested the mediation effect of sleep duration and onset time on the relationship between screen usage and retinal age gap. The retinal age gap increased with longer screen exposure, from 0.49 ± 3.51 years in the lowest tertile to 5.13 ± 4.96 years in the highest tertile (Jonckheere-Terpstra test, p < 0.001). Each additional hour of screen exposure accelerated the retinal age gap by 0.087 years (95% CI, 0.027, 0.148, p = 0.005) in the fully adjusted linear model. Sleep onset time mediated the impact of screen usage on the retinal age gap (indirect effect, β = 0.11; 95% CI 0.04–0.24). The impact of screen usage in a light-off environment on the retinal age gap was fully mediated by sleep onset time (indirect effect, β = 0.22; 95% CI 0.07–0.38), with the proportion being 100%. Our study identified a correlation between excessive screen time and a wider retinal age gap in middle-aged and elderly individuals, likely due to delayed sleep onset. To mitigate the adverse effects on the retina and aging, it is important to limit screen usage and avoid screens before bedtime.
Ultrasound-guided thread versus ultrasound-guided needle release of the A1 pulley: a cadaveric study
Authors: Jengojan Suren , Sorgo Philipp , Streicher Johannes , Snoj Žiga , Kasprian Gregor , Gruber Gerlinde , Bodner Gerd 
Published: August 2024

Abstract
Purpose
To assess and compare two ultrasound-guided, minimally invasive procedures to release the A1-pulley (needle release and thread release) regarding efficacy and safety in an anatomical specimen model.

Materials and methods
Twenty-one ultrasound-guided needle releases and 20 ultrasound-guided thread releases were performed on digits of Thiel-embalmed anatomical specimens. A scoring system was developed to assess ultrasound visibility, intervention outcome (incomplete, almost complete, or full transection of the A1 pulley), and injury to adjacent structures (neurovascular structures, tendons, A2 pulley). Statistical analysis was performed to compare the score of the two groups (group 1: needle release,group 2: thread release). A P-value of ≤ 0.05 was considered significant.

Results
Needle release was completely successful in 15 cases (71.5%), almost complete release was achieved in four cases (19%), and incomplete transection occurred in two cases (9.5%). Thread release was completely successful in 17 cases (85%), and almost complete transection was observed in the remaining three cases (15%). In both procedures no neurovascular structures were harmed. Slight injury of flexor tendons occurred in two cases (9.5%) in needle release and in five cases (25%) in thread release. There were no significant statistical differences between the groups regarding ultrasound visibility, intervention safety and outcome, (P > 0.05).

Conclusion
Ultrasound-guided needle release and ultrasound-guided thread release have similar success of release, both being effective and safe techniques for the release of the A1 pulley.

Graphical Abstract
Fabrication of free standing nano-SiO2 incorporated solid polymer electrolytes based on poly(vinyl) chloride
Authors: Jayanthi S. , Parangusan Hemalatha , babu Anandha , Balakrishnan Sundaresan , Ponnamma Deepalekshmi 
Published: August 2024

AbstractFree standing nanocomposite polymer electrolytes (NCPEs) based on the polymer host poly(vinyl) chloride (PVC) were successfully prepared using the solution casting technique. Lithium nitrate (LiNO3) and nano-sized silica (SiO2) (< 100 nm) were employed as the electrolyte and filler, respectively. Impedance studies revealed a maximum ionic conductivity value of 1.226 × 10−4 S/cm at room temperature for the PVC/LiNO3 with 5 wt.% nano-SiO2. X-ray diffraction (XRD) analysis verified the sample’s amorphous nature. Dielectric permittivity and relaxation time values were consistent with impedance results. Additionally, parameters such as diffusion coefficient, mobile concentration, and mobility were evaluated for the prepared samples. Differential scanning calorimetry (DSC) studies confirmed a change in glass transition temperature (Tg) of PVC/LiNO3/SiO2 sample. The scanning electron micrograph (SEM) images revealed a honeycomb morphology, indicating ease of Li+ ion transportation.
Experimental investigation of machine vibration rate and machine sound level in MQL turning of AISI 1525 steel employing mango oil as lubricant
Authors: Kazeem Rasaq Adebayo , Akinlabi Esther Titilayo 
Published: August 2024

AbstractThe detrimental effects of mineral oil on the environment and machine shops have led to a surge in the usage of vegetable oil as cutting fluid. The most popular vegetable oil lubricants are edible, and they have a lot of potential to rival human consumption eventually. The study examined using mango oil, an inedible vegetable oil, as a lubricant during AISI 1525 steel turning with tungsten inserts. The best machining parameters were ultimately found using the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) after the experimental studies were analyzed using the Taguchi process. Surface and contour plots were employed to investigate how different cutting settings affected the rate of vibration and sound level of the machine. Mango kernel seed oil outperformed its mineral oil counterparts by 2.3% and 57.7%, respectively, in terms of machine vibration rate and machine sound level. Moreover, feed rate (0.10 mm/rev), depth of cut (0.75 mm), and spindle speed (350 rev/min) are the ideal cutting settings to reduce machine vibrations and sound intensity. Mango oil holds significant potential as a substitute for cutting fluid derived from petroleum. The significance of this research is to formulate lubricants for industrial use that are more ecologically friendly and sustainable.