bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Mild Negishi Cross‐Coupling Reactions Catalyzed by Acenaphthoimidazolylidene Palladium Complexes at Low Catalyst Loadings.
Authors: Liu Zelong , Dong Ningning , Xu Mizhi , Sun Zheming , Tu Tao 
Published: November 2013

AbstractNegishi cross‐coupling of alkylzinc reagents with a wide range of (het)aryl halides proceeds at low catalyst loading under mild reaction conditions mostly within 30 minutes.
ChemInform Abstract: Asymmetric Indoline Synthesis via Intramolecular Aza‐Michael Addition Mediated by Bifunctional Organocatalysts.
Authors: Miyaji Ryota , Asano Keisuke , Matsubara Seijiro 
Published: November 2013

AbstractA novel asymmetric synthesis of 2‐substituted indolines is developed using intramolecular cyclization of α,β‐unsaturated ketones of type (I) in the presence of a quinidine derived bifunctional urea catalyst.
ChemInform Abstract: Catalytic Friedel—Crafts Reaction of Aminocyclopropanes.
Authors: de Nanteuil Florian , Loup Joachim , Waser Jerome 
Published: November 2013

AbstractIt is demonstrated that phthaloyl protected 2,2,2‐trifluoroethyl diester aminocyclopropanes are useful homo‐olefin equivalents in Friedel—Crafts type reactions with differently substituted indoles to provide C3 or C2 substituted indoles.
ChemInform Abstract: Copper‐Catalyzed Direct Synthesis of Iodoenamides from Ketoximes.
Authors: Liang Hao , Ren Zhi‐Hui , Wang Yao‐Yu , Guan Zheng‐Hui 
Published: November 2013

AbstractThe novel and efficient title synthesis affords regioselectively Z‐iodoenamides from readily available ketoximes.
ChemInform Abstract: Synthesis and Antimosquito Properties of 2,6‐Substituted Benzo[d]thiazole and 2,4‐Substituted Benzo[d]thiazole Analogues Against Anopheles arabiensis.
Authors: Venugopala Katharigatta Narayanaswamy , Krishnappa Manjula , Nayak Susanta K. , Subrahmanya Bhat K. , Vaderapura Jayashankaragowda P. , Chalannavar Raju K. , Gleiser Raquel M. , Odhav Bharti 
Published: November 2013

AbstractTitle compounds [(IV), (VI), and (IX)] are efficiently synthesized via three‐component condensation and screened for their antimosquito properties, where the compounds (IVa), (IVc), and (IX) show highest repellent activity.
ChemInform Abstract: Synthesis of Some Novel Chalcones, Flavanones and Flavones and Evaluation of Their Antiinflammatory Activity.
Authors: Bano Sameena , Javed Kalim , Ahmad Shamim , Rathish I. G. , Singh Surender , Chaitanya M. , Arunasree K. M. , Alam M. S. 
Published: November 2013

AbstractThe anti‐inflammatory activity of a series of novel synthesized chalcones (III), flavones (V) and flavanones (IV), derived from 2‐hydroxyacetophenones and aromatic aldehydes is presented.
ChemInform Abstract: Superior Anticancer Activity of Halogenated Chalcones and Flavonols over the Natural Flavonol Quercetin.
Authors: Dias Tatiana A. , Duarte Cecilia L. , Lima Cristovao F. , Proenca M. Fernanda , Pereira‐Wilson Cristina 
Published: November 2013

AbstractAmong the newly synthesized compounds, derivative (IId) exhibits the highest cytostatic activity.
ChemInform Abstract: Rhodium(III)‐Catalyzed C—H Activation and Amidation of Arenes Using N‐Arenesulfonated Imides as Amidating Reagents.
Authors: Yu Songjie , Wan Boshun , Li Xingwei 
Published: November 2013

AbstractArenes bearing pyridine, pyrimidine, and oxime directing groups are suitable substrates for the title reaction which proceeds without the need of a base as additive.
ChemInform Abstract: Ruthenium‐Catalyzed Intramolecular Allylic Dearomatization Reaction of Indole Derivatives.
Authors: Zhang Xiao , Liu Wen‐Bo , Wu Qing‐Feng , You Shu‐Li 
Published: November 2013

AbstractIndoles of type (I) bearing an unsaturated carbonate side chain undergo efficient spirocyclization via a Ru‐catalyzed intramolecular allylic dearomatization.
ChemInform Abstract: Electrocatalytic Fluoroalkylation of Olefins. Perfluoroalkylation of 2‐Vinylpyridine.
Authors: Khrizanforov M. N. , Gryaznova T. V. , Mikhailov D. Yu. , Budnikova Yu. H. , Sinyashin O. G. 
Published: November 2013

AbstractDepending on the electrosynthesis conditions, perfluoroalkylation of compound (I) leads either to dimeric products of addition of perfluoroalkyl substituents at the double bond of the olefin (III) or, in the presence of triethylamine, to monomeric product (IV).
ChemInform Abstract: A Novel Amalgamation of 1,2,3‐Triazoles, Piperidines and Thieno Pyridine Rings and Evaluation of Their Antifungal Activity.
Authors: Darandale Sunil N. , Mulla Nayeem A. , Pansare Dattatraya N. , Sangshetti Jaiprakash N. , Shinde Devanand B. 
Published: November 2013

AbstractThe synthesized compounds (X) exhibit moderate to good antifungal activity, wherein they are able to discriminate between different species of the same genus.
ChemInform Abstract: Organocatalysis in the Three‐Component Povarov Reaction and Investigation by Mass Spectrometry.
Authors: Simoes Juliana Baptista , de Fatima Angelo , Sabino Adao Aparecido , de Aquino Francisco Jose Torres , da Silva Daniel Leite , Barbosa Luiz Claudio Almeida , Fernandes Sergio Antonio 
Published: November 2013

AbstractA diastereoselective three‐component cascade reaction, catalyzed by 4‐sulfonic acid calix[4]arene, provides a new access to diverse julolidine derivatives (IV) in high yields.
ChemInform Abstract: Synthesis and Reactivity of 5‐Polyfluoroalkyl‐5‐deazaalloxazines.
Authors: Dudkin Sergii , Iaroshenko Viktor O. , Sosnovskikh Vyacheslav Ya. , Tolmachev Andrey A. , Villinger Alexander , Langer Peter 
Published: November 2013

AbstractReaction of 6‐arylamino‐uracils (I) with anhydrides of polyfluorocarboxylic acids (II) and subsequent cyclization with conc.
ChemInform Abstract: Enantioselective C—H Arylation Strategy for Functionalized Dibenzazepinones with Quaternary Stereocenters.
Authors: Saget Tanguy , Cramer Nicolai 
Published: November 2013

AbstractThe reaction proceeds via an enantiodiscriminating CMD (concerted metalation deprotonation) step through a rare eight‐membered palladacycle, which is unprecedented for an enantioselective process.
ChemInform Abstract: Steroids and Ceramide from the Stem Bark of Odyendyea gabonensis.
Authors: Happi Emmanuel Ngeufa , Fannang Simone Veronique , Fomani Marie , Donkwe Suzy Mireille Moladje , Nicaise Nkoungou Yomzak Carine , Wansi Jean Duplex , Sewald Norbert 
Published: November 2013

AbstractTwo new steroids (I) and (II) and one new ceramide (III) are isolated from the methylene chloride extract of the stem bark of Odyendyea gabonensis together with 11 known compounds.
ChemInform Abstract: Straightforward Synthesis of Non‐natural L‐Chalcogen and L‐Diselenide N‐Boc‐protected‐γ‐amino Acid Derivatives.
Authors: Kawasoko Cristiane Y. , Foletto Patricia , Rodrigues Oscar E. D. , Dornelles Luciano , Schwab Ricardo S. , Braga Antonio L. 
Published: November 2013

AbstractA simple, efficient and flexible route for the preparation of enantiopure selenium‐, telluro‐, and thio‐N‐protected‐γ‐amino acid derivatives (III) from glutamic acid is described.
ChemInform Abstract: Recent Advances on the Application of NMR Methods to Study the Conformation and Recognition Properties of Carbohydrates
Authors: Arda Ana , Berbis M. Alvaro , Blasco Pilar , Canales Angeles , Canada F. Javier , Fernandez‐Alonso M. Carmen , Marcelo Filipa , Jimenez‐Barbero Jesus 
Published: November 2013

AbstractReview: 117 refs.
Establishing the flow cytometric assessment of myeloid cells in kidney ischemia/reperfusion injury
Authors: Williams Timothy M. , Wise Andrea F. , Alikhan Maliha A. , Layton Daniel S. , Ricardo Sharon D. 
Published: November 2013

AbstractPolychromatic flow cytometry is a powerful tool for assessing populations of cells in the kidney through times of homeostasis, disease and tissue remodeling. In particular, macrophages have been identified as having central roles in these three settings. However, because of the plasticity of myeloid cells it has been difficult to define a specific immunophenotype for these cells in the kidney. This study developed a gating strategy for identifying and assessing monocyte and macrophage subpopulations, along with neutrophils and epithelial cells in the healthy kidney and following ischemia/reperfusion (IR) injury in mice, using antibodies against CD45, CD11b, CD11c, Ly6C, Ly6G, F4/80, CSF‐1R (CD115), MHC class II, mannose receptor (MR or CD206), an alternatively activated macrophage marker, and the epithelial cell adhesion marker (EpCAM or CD326). Backgating analysis and assessment of autofluorescence was used to extend the knowledge of various cell types and the changes that occur in the kidney at various time‐points post‐IR injury. In addition, the impact of enzymatic digestion of kidneys on cell surface markers and cell viability was assessed. Comparisons of kidney myeloid populations were also made with those in the spleen. These results provide a useful reference for future analyses of therapies aimed at modulating inflammation and enhancing endogenous remodeling following kidney injury. © 2013 International Society for Advancement of Cytometry
Oral antihistamine–decongestant–analgesic combinations for the common cold—do they work?
Authors: Fernandes Ricardo 
Published: November 2013

AbstractEco‐paediatrics is an occasional feature in Evidence‐Based Child Health: A Cochrane Review Journal. Our goal is to contribute to the worldwide discussion on reducing waste in health care. In each instalment, we will select a recent Cochrane review highlighting a practice, still in use, which the available evidence tells us should be discontinued.
Cochrane in context: Parent‐mediated early intervention for young children with autism spectrum disorders (ASD)
Authors: McConachie Helen , Oono Inalegwu 
Published: November 2013

AbstractCochrane Review: Parent‐mediated early intervention for young children with autism spectrum disorders (ASD) Oono IP, Honey EJ, McConachie H. Parent‐mediated early intervention for young children with autism spectrum disorders (ASD). Cochrane Database of Systematic Reviews 2013, Issue 4. Art. No.: CD009774. DOI: 10.1002/14651858.CD009774.pub2This companion piece, “Parent‐mediated early intervention for young children with autism spectrum disorders (ASD),” contains the following pieces:

The abstract of the review
A commentary from one or more of the review authors, explaining why the review team felt the review was an important one to produce
A review of clinical practice guidelines from the National Institute for Health and Care Excellence (NICE), United Kingdom
Triethanolamine as an Inexpensive and Efficient Ligand for Copper‐Catalyzed Hydroxylation of Aryl Halides in Water
Authors: Wang Deping , Kuang Daizhi , Zhang Fuxing , Tang Siping , Jiang Wujiu 
Published: November 2013

AbstractThe CuI/triethanolamine catalyst system efficiently promotes the direct hydroxylation of aryl iodides and bromides in water to provide the corresponding phenols in good to excellent yields. Moreover, the procedure avoids the use of toxic organic solvents and tolerates many functional groups.
Spiro‐ and Bicycloannulation of Sulfoximine‐Substituted 2‐Hydroxy‐dihydropyrans: Enantioselective Synthesis of Spiroketals, Spiroethers, and Oxabicycles and Structure of Dihydropyran Oxocarbenium Ions
Authors: Lejkowski Michal , Banerjee Prabal , Raabe Gerhard , Runsink Jan , Gais Hans‐Joachim 
Published: November 2013

AbstractA modular enantioselective synthesis of spiroketals, spiroethers, and oxabicycles, each containing a dihydropyran subunit, is described. It is based on the 2,2‐spiro‐ and 2,6‐bicycloannulation of sulfoximine‐substituted 2‐hydroxy‐dihydropyrans. Key steps of the spiroannulations are the ring‐closing metathesis of the corresponding 2,2‐oxadienyl and 2,6‐dienyl dihydropyrans and Prins cyclization of 2‐alkenyl 2‐hydroxy‐dihydropyrans. Ring‐closing metathesis of the corresponding 2,6‐dienyl dihydropyrans gave oxabicycles with oxabicyclo[4.3.1]decane skeletons. These routes were extended to the synthesis of spiroketals and spiroethers incorporating additional annulated six‐membered rings. Diastereoselective Prins cyclization of mono‐ and bicyclic 2‐alkenyl‐2‐hydroxy‐dihydropyrans was highly selective and afforded chloro‐substituted spirocycles. Substituted 2‐hydroxy‐dihydropyrans were obtained through cyclization of δ‐hydroxy ketones, which were synthesized from enantiomerically pure sulfoximine‐substituted homoallylic alcohols through lithiation and trapping of the α‐lithioalkenylsulfoximines with unsaturated aldehydes, followed by allylic oxidation. Inter‐ and intramolecular glycosidations of the 2‐hydroxy‐dihydropyrans with O‐ and C‐nucleophiles proceeded with high stereoselectivities and furnished 2,6‐trans‐configured glycosides. Dihydropyran oxocarbenium ions are most likely intermediates in the glycosidations. According to ab initio calculations, sulfoximine‐ and trimethyl‐substituted dihydropyran oxocarbenium ions adopt a half‐chair‐like conformation. The energy difference between the oxocarbenium ion with pseudoaxial and the one with pseudoequatorial methyl groups is very small. A transition state model for their reactions with nucleophiles is proposed. It features a half‐chair‐like conformation, a pseudoequatorial C6 substituent, and an anti‐addition of the nucleophile along an axial trajectory to C2 that produces an anti‐periplanar lone pair at the O atom. A similar transition state model allows a general explanation for the trans stereoselectivity of the reactions between C6‐substituted dihydropyran oxocarbenium ions and nucleophiles.
Analysis of Photovoltaics and Wind Power in Future Renewable Energy Scenarios
Authors: Kreifels Niklas , Mayer Johannes N. , Burger Bruno , Wittwer Christof 
Published: November 2013

AbstractThis study aims to shed light on the question of how the renewable coverage ratio and the corresponding share of usable energy from fluctuating production by photovoltaics (PV) and wind depends on the flexibility of the conventional power plant system, additional positive load options (i.e., power to heat), and storage capacity in the German electricity system. It was shown that a flexible power plant system with a small amount of must‐run base generation improves the ratio of renewable coverage and usable fluctuating production significantly. Flexible loads also proved to be a very effective measure for integrating renewables into the grid. The simulation suggested that large storage systems are only effective in combination with high penetration levels of PV and wind capacity. Furthermore the ratio of PV/wind capacity that yields the highest technical efficiency was evaluated regarding the ratio of renewable coverage to usable fluctuating energy for the different scenarios.
Carbon capture in molten salts
Authors: Olsen Espen , Tomkute Viktorija 
Published: November 2013

AbstractCapture and storage of fossil carbon emitted to the atmosphere from anthropogenic sources has been identified as a key technology for keeping human‐induced global warming below 2°C. Available technologies have not achieved widespread impact due to costs related to increased energy consumption and expensive, large process equipment. Here, we show how molten inorganic halide salt‐based mixtures containing CaO may be utilized for selective capture and subsequent controlled release of carbon dioxide from diluted flue gases. Highly efficient absorption is demonstrated in a fluoride‐based liquid, absorbing close to 100% of the CO2 from a simulated flue gas with an absorbing column height of only 10 cm. Greater than 90% carbonation with >80% regeneration to CaO was recorded. Excellent cyclability has been achieved with a chloride‐based liquid with 60% carbonation and 100% regeneration to CaO during four cycles. The high efficiencies may enable extraction of CO2 from highly diluted gas mixtures.
Nonparametric linkage and family‐based association studies of a simulated complex disorder
Authors: Koller Daniel L. , Balding Joanna , Foroud Tatiana 
Published: November 2013

AbstractAffected sibling pairs are widely used to identify chromosomal regions harboring genetic loci underlying common disease. We explore the utility of nonparametric sibling pair and family‐based association methods to search for disease susceptibility loci in simulated pedigree data for a qualitative disease trait. Logistic regression was used to model gene×gene and gene×environment interactions when significant linkage and association were detected. Using these methods, we were able to detect three of the four susceptibility loci underlying the disease trait with multipoint lod scores of 1.0 or greater.
Application of probabilistic neural network analysis to a disease with complex inheritance: The GAW11 simulated data
Authors: Naimark David M.J. , Paterson Andrew D. 
Published: November 2013

AbstractA probabilistic neural network analysis was applied to the simulated GAW11 data. Six replicates drawn at random from one of the simulated populations were used to generate training and test vectors for pairs of siblings. The vectors incorporated two environmental indicators as well as identical‐by‐descent allele sharing scores from each of 300 genetic markers. The performance of a ‘naïve’ probabilistic neural network (PNN) was fair. However, by combining a traditional linkage analysis with a PNN which incorporated gene×environment interaction, the performance was considerably enhanced.
The impact of marker allele frequency misspecification in variance components quantitative trait locus analysis using sibship data
Authors: Borecki Ingrid B. , Province Michael A. 
Published: November 2013

AbstractIn cases where sibship data are collected for a quantitative trait locus (QTL) linkage study without access to parental genotypes, the proportion of genes shared identical by descent must be estimated using the marker allele frequencies. No systematic study has been conducted to date to evaluate the effect of misspecification of these frequencies on a test of quantitative trait linkage. Analysis of both simulated and actual data on quantitative traits was carried out under various sets of allele frequency estimates. While correctly specifying the allele frequency distribution led to a slightly more powerful test and higher lod scores, the differences were small and would not likely alter the conclusion of a study. These results suggest that, at least for QTL analysis, there is a great deal of tolerance for misspecifying marker allele frequencies with little, if any, appreciable effect on the linkage test. However, the observed variations may be sufficiently large to alter the priority one might give to a positive finding for follow up.
Assessment of estimation procedures for risk and onset hazard with dependent data
Authors: Chase Gary A. , King Terri M. , Oja‐Tebbe Nancy , Rybicki Benjamin A. , Goldin Lynn R. 
Published: November 2013

AbstractAnalysis of the role of candidate genes as risk factors for age‐dependent hereditary conditions often ignores the importance of dependence among sibships or other family clusters for age of onset. We examined the performance of several methods of survival analysis with dependent data using Collaborative Study on the Genetics of Alcoholism families as submitted for GAW11. Additionally, an arbitrary truncation of cluster size was performed to explore the potential impact of heterogeneity of family size on the resulting inferences concerning the role of candidate genes. Our results showed substantial differences in attribution of risk to candidate genes according to whether the method utilized allowed for dependence in onset age and according to whether the sample was truncated or arbitrarily stratified. Further work needs to be done to clarify the importance of properly accounting for dependent data in age‐dependent phenotypes and in integrating these methods into widely used genetic analysis computer programs.
Detection of quantitative trait loci associated with alcohol‐dependence: Use of model‐free sib‐pair method and combined segregation‐linkage analysis based on regressive models
Authors: Durrieu Gilles , Meunier Flavie , O'Connell Jeff , Martinez Maria , Demenais Florence 
Published: November 2013

AbstractTwo linkage methods were used to detect loci underlying neurophysiological measures associated with alcohol dependence 1) the Haseman‐Elston (H‐E) sib pair method for genome‐wide search, and 2) the combined segregation‐linkage (CSL), based on regressive models, to confirm positive linkages found by the genome screening. Among 14 linkage results that were significant at the 0.5% level using H‐E, the CSL method leads to similar p‐values in only three cases but to higher p‐values in all others. Investigation of these discrepancies shows that assumptions (normality and homoscedasticity of the error term) of H‐E least‐squares regression method are not verified. A robust estimator of slope parameters without assuming any distribution function for the linear model error terms increases the p‐values and reduces the difference between H‐E and CSL results. Alternatively, the CSL approach may lack power when multiple genes with small effects are involved.
Linkage and association analyses of alcoholism using a regression‐based transmission/disequilibrium test
Authors: George Varghese , Tiwari Hemant K. , Shu Youyi , Zhu Xiaofeng , Elston Robert C. 
Published: November 2013

AbstractRecently, George et al. proposed a regression‐based transmission/disequilibrium test for linkage using information on the parent‐to‐offspring transmission status of an allele at a marker locus. We extended this test by simultaneously testing for any population association by incorporating the presence/absence status of the associated allele as a covariate in the model. We used this method to analyze markers on chromosomes 1 through 21 of the Collaborative Study on the Genetics of Alcoholism data on alcoholism for possible association and linkage. We found nominal significance (at the 0.02 level) at eight different regions for linkage, though statistical significance may not be concluded due to multiple testing. The strongest evidence of linkage was observed for markers D4S2639 and D12S397 with p‐values less than 0.005. We also found strong association between the trait and alleles 149 of D7S691 and 131 of D21S1437.
Model‐based and model‐free multipoint genome‐wide linkage analysis of alcoholism
Authors: Jacobs Kevin B. , Wedig Geoffrey C. , Schnell Audrey H. , Witte John S. , Elston Robert C. 
Published: November 2013

AbstractWe analyzed a subset of the Collaborative Study on the Genetics of Alcoholism (COGA) data set as provided by the 11th Genetic Analysis Workshop (GAW11). Linkage analyses were performed using each of the diagnostic criteria for alcoholism included in the data: the COGA criteria (DSM‐III‐R plus the Feighner criteria) and the narrower World Health Organization diagnosis ICD‐10 criteria. Formal segregation analysis using these data was not attempted because only a subset of all the originally ascertained families was made available. Nevertheless, an attempt was made to estimate the best one‐locus two‐allele genetic model for these data. Model‐based multipoint linkage analysis was performed using the results of our trait model fitting, and model‐free multipoint linkage analysis was performed with an improved version of the Haseman and Elston linkage method for sib pairs.
A semiquantitative whole genome screen analysis of alcohol dependence
Authors: John S. , Myerscough A. , Worthington J. , Barrett J.H. 
Published: November 2013

AbstractTwo whole genome screens were applied to sibling pairs from the Collaborative Study on the Genetics of Alcoholism (COGA) family data to compare a semiquantitative method with a standard qualitative approach. The semiquantitative method used a score derived from 11 symptoms, and the qualitative approach used the COGA criteria for alcohol dependence. There was no concordance in the regions identified by the two models. Three regions of nominal significance were identified using the symptom score. In these three regions, correlated traits were also analyzed to determine whether linkage could be attributed to their intermediate effect. The evidence for linkage to one locus on chromosome 6 could be explained by linkage to the personality trait harm avoidance.