bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemoproteomic profiling by a bioorthogonal probe reveals cell growth inhibition by histone H4 dopaminylation
Authors: Mo Xi , Zhang Yinfeng , Yang Yaqi , Wu Wenyan , Rao Jianan , Song Wenting , Pan Yi , Zhang Min , Min Taishan , Zhang XiaoQing , Qiu Xin-Yue , Zhang Shuyu , Yang Wenjun , Zang Jianye , Liu Yu 
Published: July 2024

Abstract

Dopaminylation, the covalent attachment of dopamine to the side chain of glutamine (Gln, Q) in proteins, has been identified as a class of posttranslational modification. Due to the limited number of substrates, the functions and underlying molecular mechanisms of dopaminylation are not fully characterized. Utilizing an alkyne-functionalized dopamine probe, we have developed a method to selectively enrich dopaminylated proteins in the whole-cell context. We identified 4,133 proteins potentially modified with dopamine and validated the modification of histone H4 glutamine 27 by dopamine (H4Q27dop). H4Q27dop mainly exerts transcriptional inhibition function in neuroblastoma cells, and can inhibit cell proliferation through downregulating cyclin D1 gene CCND1 transcription, a classical well-known proliferation booster. Our study provides a valuable resource of putative substrate proteins modified with dopamine and reveals a novel mechanism of dopamine regulating cell growth in a neuroblastoma cancer model.
Medical students’ acceptance and use of the Wi-Fi system at hostels as a learning tool: an investigation based on the 'unified theory of acceptance and use of technology'
Authors: Hettige Samankumara , Solangaarahchi Indrajith , Ediriweera Dileepa Senajith 
Published: July 2024

Abstract

Background:Universities use Wi-Fi networks to provide internet access to enhance students’ learning experience. This study evaluated the factors that might effect students’ intention to use a specific hostel Wi-Fi system for learning purposes at the Faculty of Medicine, University of Kelaniya, Sri Lanka.Methods:A cross-sectional study was conducted at the Faculty of Medicine, University of Kelaniya. The unified theory of acceptance and use of technology (UTAUT), proposed by Venkatesh et al., which explains users’ behavioral intentions to use technology, was used to design the conceptual framework. The covariance-based structural equation modelling technique was employed to analyse data collected from 310 medical students.Results:The model assessments of validity and reliability were acceptable. Among the factors studied, only performance expectancy (PE) (β = 0.284, P ≤ 0.001), social influence (SI) (β = 0.222, P ≤ 0.001), and facilitating conditions (FC) (β = 0.615, P ≤ 0.001) significantly effected on students’ intention to use the Wi-Fi system for learning, while effort expectancy (EE) (β = -0.184, P ≤ 0.130) did not. Moreover, behavioral intention (BI) (β = 0.533, P ≤ 0.001) and FC (β = 0.320, P ≤ 0.001) had significant effects on the students’ actual use of the Wi-Fi system for learning.Conclusions:This study enhances our understanding of the factors effecting medical students’ Wi-Fi access on campuses for learning purposes. Among these factors, the influence of FC was very strong. This highlights the importance of the FC, among other factors, in providing Wi-Fi network initiatives on campuses. Furthermore, university administrators can use the findings of this study to identify the requirements for the successful integration of network technologies in educational settings.
Optoelectric Raman Nanosensors: Overcoming Intrinsic Limit in Nano-biosensing
Authors: Lian Bin , Li Huaizhi , Guo Jianhe , Fan Donglei Emma 
Published: July 2024

Abstract

It is intrinsically difficult to detect low-concentration biomolecules with both ultra-sensitivity and high speed for early-stage disease diagnosis. The challenge originates from the small size of nanosensors, which enables ultra-sensitivity biosensing, while also substantially increases the detection time of dilute molecules. in this work, we report an original optoelectric sensing scheme, along with an innovative device design and a strategic fabrication approach to overcome such a challenge in biosensing. The proposed scheme exploits the profound optoelectric effect of semiconductor silicon nanowires, which can readily enrich trace-amounts of biomolecules at the point of laser and simultaneously detect Raman signals of focused molecules. The device design includes large arrays of silicon nanorods with electrodes integrated at their roots, and surface-distributed dense plasmonic silver nanoparticles for surface-enhanced Raman spectroscopy (SERS) detection. Operating at only − 0.8 V in an electrochemical cell, these optoelectric nanosensors readily achieve a 150-fold signal enhancement, improving the detection limit of probing molecules, adenine, by five orders of magnitude, to 0.6 fM. The enhancement effect is robust, observed across concentrations from 1 µM to 1 fM. The working mechanism is general, not only for detecting small molecules, such as adenine, but also for large charged molecules, such as Vertebrate DNA. The underlying novel mechanism is unraveled by multiscale numerical simulations and calculations. This research, addressing an arduous bottleneck issues in nanobiosensing, is expected to inspire a new class of biochemical sensors, important for the practical detection of trace-amount biochemicals in solution, important for clinic relevant early-stage disease diagnostics.
Level Two AC EV Charging Infrastructure Based Multilevel Inverter Grid-Tied PV System with V2G-V2H-V2V capabilities
Authors: V NANDINI 
Published: July 2024

Abstract

The concept of the electric vehicle and its adaptability paved its way almost by itself as the IC (internal combustion engines) were gradually replaced due to the depletion of fossil fuels and the emission of greenhouse gases. The electric vehicle operates solely on electricity and requires a power source to do so. In view of the increasing shift to electric vehicles, the source from which the electricity is generated should also be considered from time to time. In the current trends, renewable and hybrid energy options are more focused on charging infrastructure for electric vehicles to achieve zero emission process. This paper elaborates on the role of renewable energy in residential electric vehicle charging infrastructure. The grid-connected PV systems in the residential units are used during the day for charging the vehicles at level 2 AC. The maximum power generated by the PV source so installed is extracted by implementing the Incremental Conductance (INC) algorithm. The maximum power is obtained by using 9-level multilevel inverter which enables residential EVSE infrastructure. In addition, the implementation of bidirectional functions such as Vehicle to Grid (V2G), Vehicle to Home (V2H) and Vehicle to Vehicle (V2V) is also discussed.
High Rates of Surgical Site Infection after Cesarean Delivery in Cameroonian Referral Hospitals: A Prospective Cohort Study
Authors: Tchounzou Robert , Njamen Theophile Nana , Nkwele Fulbert Mangala , Mimesse Elise Mylène Essama , Kamdem Diane Estelle , Essome Henri , Ngowe Marcelin Ngowe 
Published: July 2024

Abstract

Background: Caesarean sections (CS) are associated with a higher incidence of surgical site infections (SSI) compared to vaginal delivery. International studies and research from peripheral hospitals in Cameroon have documented the prevalence and risk factors for SSI after CS. However, data from referral hospitals in Douala, Cameroon remains scarce. This prospective study aims to investigate the incidence and risk factors for SSI following CS in Laquintinie and Douala Gynaeco-obstetric and Paediatric hospital, two major referral hospitals in Douala. By identifying modifiable factors associated with SSI, this study hopes to contribute to the development of strategies to control this significant hospital-acquired complication.
Methods: Between February 1st and July 31st, 2022, 444 women undergoing caesarean section were enrolled in a prospective study conducted at two referral hospitals (Laquintinie hospital and Douala Gynaeco-Obstetric Hospital) in Douala, Cameroon. Standardized data collection captured sociodemographic, obstetric, and management details (pre-operative, intra-operative and post-operative information) for patients presenting with surgical site infection. Patients were followed up for 30 after caesarean section and SSI. Descriptive statistics and multivariable logistic regression analysis identified factors associated with SSI (p < 0.05).
Results: The overall incidence of SSI was 45/444 (10.13%). Laquintinie Hospital had a higher rate (11.11%) compared to Douala Gynaeco-Obstetric Hospital (6.45%). Multivariate analysis identified obesity (aOR = 5.9, p = 0.032), pre-surgical anemia (aOR = 4.7, p = 0.03), and diabetes (aOR = 15.7, p = 0.013) as independent risk factors for SSI. Blood transfusion also emerged as a risk factor (aOR = 0.05, p = 0.013).
Conclusion: This study revealed a concerningly high rate of SSI after CS in Douala referral hospitals. Addressing pre-surgical anemia, diabetes, and obesity may contribute to reducing SSIs. Further research is needed to identify causative bacteria and optimize antibiotic strategies.
Migrants' Remittances and economic growth in sub-Saharan African countries: Nonlinearity and threshold analysis
Authors: Saidi Maha , Saidi Anis , Ochi Anis 
Published: July 2024

Abstract

This paper examines the relationship between remittance inflows and economic growth for the 45 Saharan African countries over the period 2000–2020. The objective of this paper is to determine the optimal level of remittances, which, once attained, will increase economic growth with remittance inflows. By performing the dynamic panel threshold model, we found that the nexus between remittances and economic growth is nonlinear. Besides, results show that there exists a statistically positive relationship between financial transfers from migrants and economic growth above the threshold level of 12.71%, above which remittance inflows increase economic growth in the countries of sub-Saharan Africa. The findings are robust and provide circumstantial support for remittance inflows to promote economic growth. On the basis of the findings, this study proposes several policy recommendations.
JEL Classification codes : F24, F21, C24, O55
Analysis of Factors Influencing Interest in Purchasing Porang Rice Using The Extended Theory of Planned Behavior (E-TPB)
Authors: Suharno Suharno , Annisa Amalia Widya , Aziz Ibnu Wahid Fakhrudin 
Published: July 2024

Porang rice, as imitation rice made from porang tubers, can be used as a substitute for white rice because it contains low calories and high fiber. In Indonesia, the marketing of porang rice and related research is still limited. This research aims to determine the characteristics of respondents and the factors that influence interest in buying porang rice, as well as recommendations for marketing strategies based on the research results. Data were analyzed using descriptive statistics, chi-square test, and SEM-PLS. The sample used was selected using a non-probability sampling method using a purposive sampling technique. The number of respondents obtained was 112 respondents. The research results found that the knowledge and status of respondents who were on a calorie diet were the main characteristics of respondents regarding their interest in buying porang rice. Subjective norms and perceived behavioral control directly influence interest in buying porang rice. Product availability indirectly influences interest in buying porang rice through perceived behavioral control. Recommendations for manufacturers' marketing strategies include providing information about low calories and high fiber on their packaging and promotional media, expanding their partner network with retail stores that are frequently visited by the public, and maximizing sales using e-commerce.
Acute Myocardial Infarction and Chronic Kidney Disease
Authors: Freese Ballegaard Ellen Linnea , Lerkevang Grove Erik , Kamper Anne-Lise , Feldt-Rasmussen Bo , Gislason Gunnar , Torp-Pedersen Christian , Carlson Nicholas 
Published: July 2024

Key Points

Retrospective study of guideline-directed management of myocardial infarction in patients with and without CKD from 2010 to 2022.CKD was associated with lower rate of guideline-directed management and worse prognosis.Uptake of guideline-directed management increased and prognosis improved in both groups during the study period.

Background
CKD is present in >30% of patients with acute myocardial infarction (MI) and has been associated with lower rates of guideline-directed management and worse prognosis. We investigated the use of guideline-directed management and mortality risk in patients with and without CKD.

Methods
A nationwide cohort study based on health care registers encompassing all patients ≥18 years hospitalized with first-time MI in Denmark from 2010 to 2022 was conducted. CKD was defined as an eGFR <60 ml/min per 1.73 m2. Probability of guideline-directed management and risk of all-cause mortality in patients with and without CKD were calculated from adjusted multivariable logistic and Cox regression models with probabilities and risks standardized to the distribution of confounders in the population.

Results
In total, we identified 21,009 patients who met eligibility criteria. The median age was 72 years, and 61% of patients were male; the median eGFR was 82 ml/min per 1.73 m2, and 21% of patients had CKD. The 30-day probabilities of coronary angiography and revascularization were 71% (95% confidence interval [CI], 69% to 72%) and 78% (95% CI, 77% to 79%), P < 0.001 and 52% (95% CI, 50% to 54%) and 58% (95% CI, 58% to 59%), P < 0.001, in patients with and without CKD, respectively. Probabilities increased during the study period (P for trend 0.05, 0.03, 0.02, and 0.03, respectively). In patients with and without CKD, the probability of dual antiplatelet therapy was 67% (95% CI, 65% to 68%) and 70% (95% CI, 69% to 71%), P = 0.001, whereas the probability of lipid-lowering treatment was 76% (95% CI, 75% to 78%) and 82% (95% CI, 81% to 83%), P < 0.001, respectively. The associated 1-year mortality was 21% (95% CI, 20% to 22%) and 16.4% (95% CI, 16% to 17%) in patients with and without CKD, respectively. with decreasing mortality rates in both groups during the study period (P for trend 0.03 and 0.01).

Conclusions
Although survival after MI improved for all patients, CKD continued to be associated with lower use of guideline-directed management and higher mortality.
Providers' Experiences Discussing Care for Patients with Kidney Failure Who Forgo KRT
Authors: Wong Susan P.Y. , Chotivatanapong Julie , Lee Deborah , Lam Daniel Y. , van Eijk Marieke S. 
Published: July 2024

Key Points

Nephrology providers disagreed on the terms to use and their definitions when describing care for patients who forgo KRT.Many nephrology providers had difficulty interpreting what patients might mean when they express a desire to forgo KRT.There is a need to improve provider communication and understanding of care for patients who forgo KRT.

Background
Many nephrology providers express difficulty in discussing care options for patients who forgo KRT, which hampers their ability to help patients make decisions about their current and future treatment of kidney disease.

Methods
We conducted a qualitative study using interviews with a national sample of nephrology providers (i.e., physicians and advanced practice providers) who participated in US professional societies between July and December 2022. We performed a thematic analysis of interviews to identify emergent themes reflecting providers' experiences discussing care for patients who forgo KRT.

Results
There were 21 providers (age 54±13 years, female 81%, White 32%) who participated in interviews, of whom 43% were physicians and most (57%) practiced in academic settings. Three dominant themes emerged from interviews reflecting challenges to discussing the option to forgo KRT: (1) Inconsistent terminology: while providers sought to use terms to describe care for patients who forgo KRT that affirmed patients' decision, clearly conveyed that KRT would not be pursued, and were already familiar to patients and other providers, they disagreed about which terms satisfied these priorities; (2) blurred distinctions between KRT and its alternative: providers' descriptions of their care practices suggested that differences in their approaches to caring for patients who forgo KRT and those who are planning to pursue KRT could be opaque; and (3) deciphering patients' decision to forgo KRT: providers did not readily accept patients' expressed preferences to forgo KRT at face value and described using a variety of methods to assess whether patients would follow through with their decision.

Conclusions
Providers used different, inconsistent terms to describe care for patients who forgo KRT. They disagreed about what this care entailed and were uncertain about what patients might mean when they express not wanting to undergo KRT.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2024_10_21_CJASNOctober1910102.mp3
INTERNALISASI PENDIDIKAN MULTIKULTURAL TERHADAP PERUBAHAN KARAKTER ANAK USIA DINI DI TK ABA SUKAJAWA LAMPUNG TENGAH
Authors: Baity Nisrina Salsabila  , Nina Tisnawati  , Firdausyi Annisa Nur 
Published: July 2024

Indonesia merupakan bangsa majemuk, bangsa yang terdiri dari berbagai suku, agama dan bahasa. Kemajemukan ini tentu saja mengakibatkan banyaknya perbedaan seperti budaya, adat Istiadat,ras,suku,kebiasaan.Perbedaan tentu saja menyebabkan perpecahan yang memberikan dampak pada perkembangan karater anak usia dini. Salah satu dampaknya muncul bibit radikalisme yang dialami pada anak anak khususnya seperti rasis dan bullying terhadap teman atau kelompok yang dianggap berbeda oleh mereka. Oleh karena itu mengingat pentingnya pemahaman mengenai keberagaman budaya di Indonesia,maka pendidikan multikultural perlu diinternalisasikan dijiwa masyarakat. Salah satu yang dapat dilakukan adalah memberikan pendidikan multikultural sejak awal kepada anak usia dini. Jenis penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan fenomenologi. Teknik pengumpulan data menggunakan wawancara,observasi,dokumentasi. Kemudian menggunakan analisis deskriptif yang respondennya merupakan kepala sekolah,guru,wali murid,20 peserta didik diantaranya bersuku lampung dan banten. Hasil penelitian yang dilakukan di TK ABA Sukajawa yaitu terdapat dua program dalam internalisasi pendikan multikutural yaitu1) Program pengembangan diri, yakni terdapat empat kegiatan yaitu: kegiatan rutin, kegiatan spontan, keteladanan, pengkondisian.2).Pengintegrasian dalam mata pelajaran yakni: pendidikan multikultual yang diberikan menimbulkan perubahan pada aspek keterbukaan, pada siswa bersuku Lampung mengalami peningkatan 90%, bersuku Jawa mengalami peningkatan 80%. Aspek Empati, siswa bersuku Lampung mengalami peningkatan 80%, bersuku Jawa mengalami peningkatan 90%. Aspek toleransi juga mengalami perubahan, dengan siswa bersuku Lampung meningkat 80%, dan bersuku Jawa meningkat 60%, aspek kerjasama, siswa bersuku Lampung mengalami peningkatan 90%, bersuku Jawa mengalami peningkatan 90%. Sehingga dapat disimpulkan pendidikan multikultural memiliki pengaruh positif dalam meningkatkan keterbukaan, empati, toleransi, dan kerjasama pada anak usia dini.
Kata kunci: Internalisasi, Pendidikan Multikultural
A systematic review of Chinese students’ online learning experiences
Authors: Mao Yiyi , Lee Kyungmee 
Published: July 2024

Abstract
The COVID-19 pandemic prompts a number of university students to engage in online learning. China is one of the countries that has experienced a radical shift in this sense. Before the pandemic, the online mode of university study was not recognised as a legitimate educational experience in China; thus, a small number of Chinese students engaged in online learning. Subsequently, there was a relatively incomplete understanding of their online learning experiences. Given the exponential expansion of online learning in China since the pandemic, it would be a timely effort to synthesise knowledge on online Chinese students’ experiences. For that purpose, the present article presents the results of a systematic literature review of 34 published journal articles concerning Chinese students’ online learning journey. The results give a deep insight into Chinese distance higher education from students’ perspectives and call for more studies on the implications of relevant policy and cultural dimensions on Chinese students’ online learning experiences.
ЦИФРОВІ ІНСТРУМЕНТИ В ДІЯЛЬНОСТІ ПЕДАГОГА ПРОФЕСІЙНОГО НАВЧАННЯ
Authors: Ковальчук Андрій 
Published: July 2024

Розкрито роль цифровізації освіти в професійній підготовці педагога професійного навчання. Визначено вплив цифрових технологій на ефективність освітнього процесу та формування майбутнього фахівця. Виокремлено групи цифрових інструментів які використовуються в освітньому процесі. Сформульовано ключове поняття “цифрові інструменти” – це програмні або апаратні засоби, які використовуються для обробки, зберігання, передачі або відтворення інформації у цифровій формі й допомагають створювати, редагувати, аналізувати та обмінюватися цифровим контентом, сприяють взаємодії та комунікації в онлайн-середовищі.
Religion as a Resource? The Impact of Religiosity on the Sense of Purpose in Life of Young Muslim Refugees in Germany
Authors: Engel Daniel , Penthin Marcus , Pirner Manfred , Riegel Ulrich 
Published: July 2024

This study examines the relationship between religiosity and purpose in life among young Muslim refugees (n = 222; Mage = 20.18 years) in Germany, a topic little explored to date. Consistent with previous research, respondents felt a moderate but positive sense of purpose in life, which was fostered by religiosity. Regression analysis demonstrated that even after controlling for physical health and social support, religiosity remained a substantial predictor of purpose in life; its effect size did not differ significantly from the other two variables in the model. The findings emphasize the importance of religiosity and social support for young Muslim refugees’ well-being.
Effect of Different Conditioning Methods on Shear Bond Strength of Orthodontic Ceramic Brackets Bonded to Porcelain Ceramic Surface
Authors: H. Dheyab Marwa , K. Al-Joubori Sami 
Published: July 2024

The study aimed to investigate the shear bond strength (SBS) of orthodontic ceramic brackets bonded to porcelain ceramic surfaces that had undergone various conditioning methods. Materials and Methods: Forty ceramic discs were fabricated (vita vmk master®, zahnfabric, Germany) with a diameter of (4*10mm). Ceramic discs were divided into four groups (n = 10) according to ceramic surface conditioning methods, 37% phosphoric acid (PH), 9%hydrofluoric acid (HF), and surface conditioning with a fine diamond bur. Transbond XT light-cure composite was used to bond ceramic brackets. Before bonding, extra samples from each group were chosen to be examined using a scanning electron microscope (SEM) to determine the topography of the ceramic surface. The Shear Bond Strength data were evaluated using one-way analysis of variance (ANOVA) and Tukey HSD tests. Under an optical stereomicroscope, debond surfaces were examined. Results: Surface conditioning with a fine diamond bur + HF acid etching group produced the highest SBS (30.64 ± 7.28 MPa), and the lowest SBS was investigated in the PH acid etching group (14.75 ±3.32 MPa). Conclusions: Different conditioning methods affected the porcelain ceramic surface's shear bond strength (P < 0.05). The highest SBS was found in the fine diamond bur_+ HF acid etching group; however, this had a deleterious effect on the ceramic surface after debonding.