bluuebunny/crossref_metadata_2025_split huggingface dataset:
A record of Eocene (Stronsay Group) sedimentation in BGS borehole 99/3, offshore NW Britain: Implications for early post-break-up development of the Faroe–Shetland Basin
Authors: Stoker M. S. , Leslie A. B. , Smith K. 
Published: November 2013

Synopsis
A punctuated Eocene succession has been recovered in British Geological Survey borehole 99/3 from the Faroe–Shetland Basin. The borehole was drilled close to the crest of the Judd Anticline and penetrated 110.5 m into the post-break-up Stronsay Group. The borehole proved 23.8 m of Ypresian–earliest Lutetian paralic to shallow-marine deposits, unconformably overlain by 43.85 m of mid-Lutetian lower shoreface to shallow-marine shelf deposits, in turn unconformably overlain by 42.85 m of late Bartonian–Priabonian mass-flow (slope apron) and basinal deposits. At the borehole site, the Ypresian–earliest Lutetian sediments were subaerially exposed in early Lutetian times; these deposits were subsequently transgressed by the mid-Lutetian shelf – itself eroded in the late Lutetian with reworked material transported northwards and re-deposited in the Mid-Eocene basin-floor fan complex in Quadrants 213 and 214. The eroded mid-Lutetian shelf was subsequently downlapped and buried beneath prograding late Bartonian–Priabonian slope apron-to-basinal sediments as the borehole site subsided. Integrating the borehole data with the regional seismic-stratigraphy indicates three major intervals of regression – early/mid-Lutetian, late Lutetian and late Bartonian – which, it is suggested, coincide predominantly with tectonic activity, particularly compressional deformation, possibly linking the early post-break-up development of the Faroe–Shetland Basin to the evolution of the adjacent Norwegian Basin.
Prodigiosin Rescues Deficient p53 Signaling and Antitumor Effects via Upregulating p73 and Disrupting Its Interaction with Mutant p53
Authors: Hong Bo , Prabhu Varun V. , Zhang Shengliang , van den Heuvel A. Pieter J. , Dicker David T. , Kopelovich Levy , El-Deiry Wafik S. 
Published: November 2013

Abstract
p53 reactivation offers a broad-based strategy for cancer therapy. In this study, we report the identification of prodigiosin that can reactivate p53 family-dependent transcriptional activity in p53-deficient human colon cancer cells. Prodigiosin and its structural analogue (compound R) induced the expression of p53 target genes accompanied by cell-cycle arrest and apoptosis in p53-deficient cancer cells. Prodigiosin restored p53 signaling in cancer cells harboring hotspot TP53 mutations, with little to no detectable cytotoxicity in normal human fibroblasts and with no genotoxicity. Prodigiosin induced the expression of p73 and disrupted its interaction with mutant p53, thereby rescuing p53 pathway deficiency and promoting antitumor effects. The disruption of mutant p53/p73 interaction was specific to prodigiosin and not related to mTOR inhibition. Our findings suggest that mutant p53 needs to be targeted in the context of p73 stimulation to allow efficient restoration of the p53 pathway. In exhibiting this capability, prodigiosin and its analogue provide lead compounds to rescue deficiencies in the p53 pathway in cancer cells by upregulating p73 and targeting mutant p53/p73 interaction there. Cancer Res; 74(4); 1153–65. ©2013 AACR.
Inhibition of CSF-1 Receptor Improves the Antitumor Efficacy of Adoptive Cell Transfer Immunotherapy
Authors: Mok Stephen , Koya Richard C. , Tsui Christopher , Xu Jingying , Robert Lídia , Wu Lily , Graeber Thomas G. , West Brian L. , Bollag Gideon , Ribas Antoni 
Published: November 2013

Abstract
Colony stimulating factor 1 (CSF-1) recruits tumor-infiltrating myeloid cells (TIM) that suppress tumor immunity, including M2 macrophages and myeloid-derived suppressor cells (MDSC). The CSF-1 receptor (CSF-1R) is a tyrosine kinase that is targetable by small molecule inhibitors such as PLX3397. In this study, we used a syngeneic mouse model of BRAFV600E-driven melanoma to evaluate the ability of PLX3397 to improve the efficacy of adoptive cell therapy (ACT). In this model, we found that combined treatment produced superior antitumor responses compared with single treatments. In mice receiving the combined treatment, a dramatic reduction of TIMs and a skewing of MHCIIlow to MHCIIhi macrophages were observed. Furthermore, mice receiving the combined treatment exhibited an increase in tumor-infiltrating lymphocytes (TIL) and T cells, as revealed by real-time imaging in vivo. In support of these observations, TILs from these mice released higher levels of IFN-γ. In conclusion, CSF-1R blockade with PLX3397 improved the efficacy of ACT immunotherapy by inhibiting the intratumoral accumulation of immunosuppressive macrophages. Cancer Res; 74(1); 153–61. ©2013 AACR.
Interaction of Delta-like 1 Homolog (Drosophila) with Prohibitins and Its Impact on Tumor Cell Clonogenicity
Authors: Begum Asma , Lin Qun , Yu Chenye , Kim Yuri , Yun Zhong 
Published: November 2013

Abstract
Cancer stem cell characteristics, especially their self-renewal and clonogenic potentials, play an essential role in malignant progression and response to anticancer therapies. Currently, it remains largely unknown what pathways are involved in the regulation of cancer cell stemness and differentiation. Previously, we found that delta-like 1 homolog (Drosophila) or DLK1, a developmentally regulated gene, plays a critical role in the regulation of differentiation, self-renewal, and tumorigenic growth of neuroblastoma cells. Here, we show that DLK1 specifically interacts with the prohibitin 1 (PHB1) and PHB2, two closely related genes with pleiotropic functions, including regulation of mitochondrial function and gene transcription. DLK1 interacts with the PHB1–PHB2 complex via its cytoplasmic domain and regulates mitochondrial functions, including mitochondrial membrane potential and production of reactive oxygen species. We have further found that PHB1 and especially PHB2 regulate cancer cell self-renewal as well as their clonogenic potential. Hence, the DLK1–PHB interaction constitutes a new signaling pathway that maintains clonogenicity and self-renewal potential of cancer cells.
Implications: This study provides a new mechanistic insight into the regulation of the stem cell characteristics of cancer cells. Mol Cancer Res; 12(1); 155–64. ©2013 AACR.
Untreated Stage IV Melanoma Patients Exhibit Abnormal Monocyte Phenotypes and Decreased Functional Capacity
Authors: Chavan Rahul , Salvador Daniela , Gustafson Michael P. , Dietz Allan B. , Nevala Wendy , Markovic Svetomir N. 
Published: November 2013

Abstract
Monocytes may contribute to tumor progression in part by mediating tumor-induced immunosuppression. Alterations to the monocyte populations and functions in untreated patients with late-stage melanoma are not fully understood. To characterize these alterations, we compared the frequency, phenotype, and functional capacity of peripheral blood monocytes and other myeloid cells in untreated, newly diagnosed stage IV melanoma patients (n = 18) with those in healthy volunteers. Stage IV untreated melanoma patients exhibited a sizeable decrease in the percentage of monocytes (P &lt; 0.0001) that included a drop in the percentage of the CD14+CD16− classical monocyte pool (P = 0.006). Although there was not a significant difference in the CD14+HLA-DRlow/− monocyte population between the patients with melanoma and the healthy volunteers, the HLA-DR levels were considerably lower in the patients' CD14+CD16+ intermediate (P &lt; 0.0001) and CD14lowCD16+ nonclassical monocyte populations (P = 0.001). Decreased surface expression of CD86 (P = 0.0006) and TNFRII (P = 0.0001) and increased expression of tissue factor and PD-L1 (P = 0.003) were identified on monocytes from patients with melanoma. Furthermore, these monocytes had decreased ability to upregulate CD80 expression and cytokine production following stimulation with agonist of Toll-like receptor 3 (TLR3). Peripheral blood dendritic cell subsets were decreased in untreated stage IV melanoma patients. Our study demonstrates that untreated late-stage melanoma patients exhibit monocytopenia in addition to phenotypic and functional deficiencies that may negatively affect their immune function. These findings open new avenues into examining the role of monocyte populations in melanoma development. Cancer Immunol Res; 2(3); 241–8. ©2013 AACR.
Relevance of Islamic Dispute Resolution Processes in Islamic Banking and Finance
Authors: Rasyid Abdul 
Published: November 2013

Abstract
In the Islamic legal system, the ways in which disputes are resolved generally fall under two categories. The first category is through litigation, namely in Islamic courts (al-qaḍāʾ or adjudication), and the second is through amicable means such as negotiation, conciliation and compromise (naṣīḥah or sincere advice), mediation (ṣulḥ), arbitration (taḥkīm), mediation along with arbitration (ṣulḥ and taḥkīm), an ombudsman (muḥtasib), expert determination (Mufti’s fatwā, pl. fatāwā), etc. These mechanisms are called alternative dispute resolution (ADR) that refers to a range of dispute resolution processes which are alternative to traditional litigation. Over time, the term ADR is now coming to mean ‘appropriate dispute resolution’ or the most appropriate resolution process in the given circumstances. One of the principal goals of ADR is to provide parties with choices for the effective and efficient resolution of disputes. The above-mentioned dispute resolution processes have different characteristics. This article will discuss only the relevant mechanisms with a view to examine how far they may be suitable to resolve Islamic banking and finance disputes effectively, cheaply and quickly.
Early accelerated senescence of circulating endothelial progenitor cells in premature coronary artery disease patients in a developing country - a case control study
Authors: Vemparala Kranthi , Roy Ambuj , Bahl Vinay Kumar , Prabhakaran Dorairaj , Nath Neera , Sinha Subrata , Nandi Pradipta , Pandey Ravindra Mohan , Reddy Kolli Srinath , Manhapra Ajay , Lakshmy Ramakrishnan 
Published: November 2013

Abstract

Background
The decreased number and senescence of circulating endothelial progenitor cells (EPCs) are considered markers of vascular senescence associated with aging, atherosclerosis, and coronary artery disease (CAD) in elderly. In this study, we explore the role of vascular senescence in premature CAD (PCAD) in a developing country by comparing the numerical status and senescence of circulating EPCs in PCAD patients to controls.

Methods
EPCs were measured by flow cytometry in 57 patients with angiographically documented CAD, and 57 controls without evidence of CAD, recruited from random patients ≤ 50 years of age at All India Institute of Medical Sciences. EPC senescence as determined by telomere length (EPC-TL) and telomerase activity (EPC-TA) was studied by real time polymerase chain reaction (q PCR) and PCR– ELISA respectively.

Result
The number of EPCs (0.18% Vs. 0.039% of total WBCs, p < 0.0001), and EPC-TL (3.83 Vs. 5.10 kb/genome, p = 0.009) were markedly lower in PCAD patients compared to controls. These differences persisted after adjustment for age, sex, BMI, smoking and medications. EPC-TA was reduced in PCAD patients, but was statistically significant only after adjustment for confounding factors (1.81 Vs. 2.20 IU/cell, unadjusted p = 0.057, adjusted p = 0.044).

Conclusions
We observed an association between increased vascular cell senescence with PCAD in a sample of young patients from India. This suggests that early accelerated vascular cell senescence may play an important mechanistic role in CAD epidemic in developing countries like India where PCAD burden is markedly higher compared to developed countries.
Imaging of temperature dependent hemodynamics in the rat sciatic nerve by functional photoacoustic microscopy
Authors: Liao Lun-De , Orellana Josue , Liu Yu-Hang , Lin Yan-Ren , Vipin Ashwati , Thakor Nitish V , Shen Kaiquan , Wilder-Smith Einar 
Published: November 2013

Abstract

Background
Vascular hemodynamics is central to the regulation of neuro-metabolism and plays important roles in peripheral nerves diseases and their prevention. However, at present there are only a few techniques capable of directly measuring peripheral nerve vascular hemodynamics.

Method
Here, we investigate the use of dark-field functional photoacoustic microscopy (fPAM) for intrinsic visualizing of the relative hemodynamics of the rat sciatic nerve in response to localized temperature modulation (i.e., cooling and rewarming).

Results and conclusion
Our main results show that the relative functional total hemoglobin concentration (HbT) is more significantly correlated with localized temperature changes than the hemoglobin oxygen saturation (SO2) changes in the sciatic nerve. Our study also indicates that the relative HbT changes are better markers of neuronal activation than SO2 during nerve temperature changes. Our results show that fPAM is a promising candidate for in vivo imaging of peripheral nerve hemodynamics without the use of contrast agents. Additionally, this technique may shed light on the neuroprotective effect of hypothermia on peripheral nerves by visualizing their intrinsic hemodynamics.
The Lagrange-Galerkin method for fluid-structure interaction problems
Authors: San Martín Jorge , Scheid Jean-François , Smaranda Loredana 
Published: November 2013

Abstract
In this paper, we consider a Lagrange-Galerkin scheme to approximate a two-dimensional fluid-structure interaction problem. The equations of the system are the Navier-Stokes equations in the fluid part, coupled with ordinary differential equations for the dynamics of the solid. We are interested in studying numerical schemes based on the use of the characteristics method for rigid and deformable solids. The schemes are based on a global weak formulation involving only terms defined on the whole fluid-solid domain. Convergence results are stated for both semi and fully discrete schemes. This article reviews known results for rigid solid along with some new results on deformable structure yet to be published.
Severe hypersensitivity pneumonitis associated with everolimus therapy for neuroendocrine tumour: a case report
Authors: Sibertin-Blanc Camille , Norguet Emmanuelle , Duluc Muriel , Louis Guillaume , Seitz Jean-François , Dahan Laetitia 
Published: November 2013

Abstract

Background
Novel therapeutic agents are currently being investigated for neuroendocrine tumour treatment.

Case presentation
We report here on the case of a patient presenting with hypersensitivity pneumonitis while being treated with everolimus, a mammalian target of rapamycin (mTOR) inhibitor.

Conclusion
Side effects of everolimus should be familiar to clinicians, including nonspecialists, and be monitored carefully to allow for prompt management.
Spatio-temporal analysis of host preferences and feeding patterns of malaria vectors in the sylvo-pastoral area of Senegal: impact of landscape classes
Authors: Ngom El Hadji Malick , Ndione Jacques-André , Ba Yamar , Konaté Lassana , Faye Ousmane , Diallo Mawlouth , Dia Ibrahima 
Published: November 2013

Abstract

Background
The study of vector feeding behaviour is an important step in the understanding of the epidemiology of vector borne diseases. The main objective of this work was to study the spatio-temporal host preferences and blood-feeding patterns of malaria vectors in a pastoral area of Senegal where cattle breeding is the main human activity.

Methods
Malaria vectors were collected indoors by pyrethrum spray catch in 16 villages belonging to 4 different landscape classes (wooded savanna, shrubby savanna, bare soils and steppe). Blood meals sources were determined using a direct enzyme-linked immunosorbent assay (ELISA).

Results
The blood meal origins of 1886 freshly fed An. gambiae s.l. were determined. Among these blood meals, most were taken on a single host: 40.1% on human and 37.1% on animal. The range in proportions of blood meals taken from human were 25–62.4% in wooded savanna villages, 23.5–61.9% in shrubby savanna villages, 31.3–70% in bare soils villages and 57.7–68.7 in steppe villages. Blood meals taken from bovines were very heterogeneous with two clusters localized in the Northeast and Southwest axis of the study area that corresponds to the distribution of the main water ponds. Patent mixed blood meals taken from human and non-human were significantly higher than those taken from two animals, the highest proportions being observed in September (shrubby savanna, bare soils and steppe villages) or October (wooded savanna villages).

Conclusions
These observations suggest that in this pastoral area, differences in feeding patterns of malaria vectors are merely linked to the specific localization of villages and are not influenced by landscape class distribution. In addition, the temporal variations in the anthropophilic rates are influenced by the presence of standing water in the study area.
Pharmacological enhancement of mGlu1 metabotropic glutamate receptors causes a prolonged symptomatic benefit in a mouse model of spinocerebellar ataxia type 1
Authors: Notartomaso Serena , Zappulla Cristina , Biagioni Francesca , Cannella Milena , Bucci Domenico , Mascio Giada , Scarselli Pamela , Fazio Francesco , Weisz Filippo , Lionetto Luana , Simmaco Maurizio , Gradini Roberto , Battaglia Giuseppe , Signore Michele , Puliti Aldamaria , Nicoletti Ferdinando 
Published: November 2013

Abstract

Background
Spinocerebellar ataxia type 1 (SCA1) is a genetic disorder characterized by severe ataxia associated with progressive loss of cerebellar Purkinje cells. The mGlu1 metabotropic glutamate receptor plays a key role in mechanisms of activity-dependent synaptic plasticity in the cerebellum, and its dysfunction is linked to the pathophysiology of motor symptoms associated with SCA1. We used SCA1 heterozygous transgenic mice (Q154/Q2) as a model for testing the hypothesis that drugs that enhance mGlu1 receptor function may be good candidates for the medical treatment of SCA1.

Results
Symptomatic 30-week old SCA1 mice showed reduced mGlu1 receptor mRNA and protein levels in the cerebellum. Interestingly, these mice also showed an intense expression of mGlu5 receptors in cerebellar Purkinje cells, which normally lack these receptors. Systemic treatment of SCA1 mice with the mGlu1 receptor positive allosteric modulator (PAM), Ro0711401 (10 mg/kg, s.c.), caused a prolonged improvement of motor performance on the rotarod and the paw-print tests. A single injection of Ro0711401 improved motor symptoms for several days, and no tolerance developed to the drug. In contrast, the mGlu5 receptor PAM, VU0360172 (10 mg/kg, s.c.), caused only a short-lasting improvement of motor symptoms, whereas the mGlu1 receptor antagonist, JNJ16259685 (2.5 mg/kg, i.p.), further impaired motor performance in SCA1 mice. The prolonged symptomatic benefit caused by Ro0711401 outlasted the time of drug clearance from the cerebellum, and was associated with neuroadaptive changes in the cerebellum, such as a striking reduction of the ectopically expressed mGlu5 receptors in Purkinje cells, increases in levels of total and Ser880-phosphorylated GluA2 subunit of AMPA receptors, and changes in the length of spines in the distal dendrites of Purkinje cells.

Conclusions
These data demonstrate that pharmacological enhancement of mGlu1 receptors causes a robust and sustained motor improvement in SCA1 mice, and lay the groundwork for the development of mGlu1 receptor PAMs as novel “cerebellum-specific”, effective, and safe symptomatic drugs for the treatment of SCA1 in humans.
ATM-depletion in breast cancer cells confers sensitivity to PARP inhibition
Authors: Gilardini Montani Maria Saveria , Prodosmo Andrea , Stagni Venturina , Merli Dania , Monteonofrio Laura , Gatti Veronica , Gentileschi Maria Pia , Barilà Daniela , Soddu Silvia 
Published: November 2013

Abstract

Background
Mutations in the DNA damage response (DDR) factors, breast cancer 1 (BRCA1) and BRCA2, sensitize tumor cells to poly(ADP-ribose) polymerase (PARP) inhibitors. The ataxia telangiectasia mutated (ATM) kinase is a key DDR protein whose heterozygous germline mutation is a moderate–risk factor for developing breast cancer. In this study, we examined whether ATM inactivation in breast cancer cell lines confers sensitivity to PARP inhibitors.

Methods
Wild-type BRCA1/2 breast cancer cells (i.e., MCF-7 and ZR-75-1 lines) were genetically manipulated to downregulate ATM expression then assayed for cytostaticity/cytotoxicity upon treatment with PARP inhibitors, olaparib and iniparib.

Results
When ATM-depleted cells and their relative controls were treated with olaparib (a competitive PARP-1/2 inhibitor) and iniparib (a molecule originally described as a covalent PARP-1 inhibitor) a different response to the two compounds was observed. ATM-depletion sensitized both MCF-7 and ZR-75-1 cells to olaparib-treatment, as assessed by short and long survival assays and cell cycle profiles. In contrast, iniparib induced only a mild, ATM-dependent cytostatic effect in MCF-7 cells whereas ZR-75-1 cells were sensitive to this drug, independently of ATM inactivation. These latest results might be explained by recent observations indicating that iniparib acts with mechanisms other than PARP inhibition.

Conclusions
These data indicate that ATM-depletion can sensitize breast cancer cells to PARP inhibition, suggesting a potential in the treatment of breast cancers low in ATM protein expression/activity, such as those arising in mutant ATM heterozygous carriers.
HPV positive tonsillar cancer in two laser surgeons: Case reports
Authors: Rioux Margo , Garland Andrea , Webster Duncan , Reardon Edward 
Published: November 2013

A 53 year-old male gynecologist presented with human papillomavirus (HPV) 16 positive tonsillar squamous cell carcinoma. He had no identifiable risk factors with the exception of long term occupational exposure to laser plumes, having performed laser ablations and loop electrosurgical excision procedures (LEEP) on greater than 3000 dysplastic cervical and vulvar lesions over 20 years of practice. The second patient is a 62 year old male gynecologist with a 30 year history of laser ablation and LEEP who subsequently developed HPV 16 positive base of tongue cancer. He also had very few other risk factors for oropharyngeal cancer or HPV infection. HPV is a probable causative agent for oropharyngeal squamous cell carcinoma and has been reported as being transmittable through laser plume. This paper suggests that HPV transmitted through laser plume can result in subsequent squamous cell carcinoma.
Simultaneous osseous metaplasia nodules of the submucosa and mesosalpinx after first trimester abortion: a case report
Authors: Feng Zhou , Jiale Qin , Xiaofei Zhang , Qingyun Guo , Lili Huang 
Published: November 2013

Abstract

Objectives
Here, we report a case of simultaneous osseous metaplasia nodules of the submucosa and mesosalpinx after a first trimester abortion.

Case presentation
A 36-year-old woman presented to the Women’s Hospital, School of Medicine, Zhejiang University with vaginal bleeding and infertility resulting from osseous metaplasia nodules of the submucosa and mesosalpinx after a first trimester abortion. Diagnostic and operative hysteroscopy and laparoscope procedures were performed. The osseous metaplasia nodules disappeared after hysteroscopy and laparoscope interventions; 2 weeks postoperatively, the patient underwent a transvaginal ultrasound examination and the abnormal ultrasound appearance had resolved.

Conclusions
Osseous metaplasia nodules in the submucosa and mesosalpinx can be a rare cause of vaginal bleeding and infertility. Autologous tissue, not persistent heterologous tissue, may be the true reason for metaplasia. Treatment is by ultrasound-guided curettage or by hysteroscopic and laparoscope removal.