bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis and management of non-criteria obstetric antiphospholipid syndrome
Authors: Machin Samuel J. , Mackie Ian J. , Cohen Hannah , Jayakody Arachchillage Deepa R. 
Published: October 2014

SummaryAccurate diagnosis of obstetric antiphospholipid syndrome (APS) is a prerequisite for optimal clinical management. The international consensus (revised Sapporo) criteria for obstetric APS do not include low positive anticardiolipin (aCL) and anti β2 glycoprotein I (aβ2GPI) antibodies (> 99th centile) and/or certain clinical criteria such as two unexplained miscarriages, three non-consecutive miscarriages, late preeclampsia, placental abruption, late premature birth, or two or more unexplained in vitro fertilisation failures. In this review we examine the available evidence to address the question of whether patients who exhibit non-criteria clinical and/or laboratory manifestations should be included within the spectrum of obstetric APS. Prospective and retrospective cohort studies of women with pregnancy morbidity, particularly recurrent pregnancy loss, suggest that elimination of aCL and/or IgM aβ2GPI, or low positive positive aCL or aβ2GPI from APS laboratory diagnostic criteria may result in missing the diagnosis in a sizeable number of women who could be regarded to have obstetric APS. Such prospective and retrospective studies also suggest that women with non-criteria obstetric APS may benefit from standard treatment for obstetric APS with low-molecular-weight heparin plus low-dose aspirin, with good pregnancy outcomes. Thus, non-criteria manifestations of obstetric APS may be clinically relevant, and merit investigation of therapeutic approaches. Women with obstetric APS appear to be at a higher risk than other women of pre-eclampsia, placenta- mediated complications and neonatal mortality, and also at increased long-term risk of thrombotic events. The applicability of these observations to outcomes in women with non-criteria obstetric APS remains to be determined.
Vascularisation for cardiac tissue engineering: the extracellular matrix
Authors: Patra Chinmoy , Boccaccini Aldo , Engel Felix 
Published: October 2014

SummaryCardiovascular diseases present a major socio-economic burden. One major problem underlying most cardiovascular and congenital heart diseases is the irreversible loss of contractile heart muscle cells, the cardiomyocytes. To reverse damage incurred by myocardial infarction or by surgical correction of cardiac malformations, the loss of cardiac tissue with a thickness of a few millimetres needs to be compensated. A promising approach to this issue is cardiac tissue engineering. In this review we focus on the problem of in vitro vascularisation as implantation of cardiac patches consisting of more than three layers of cardiomyocytes (> 100 μm thick) already results in necrosis. We explain the need for vascularisation and elaborate on the importance to include non-myocytes in order to generate functional vascularised cardiac tissue. We discuss the potential of extracellular matrix molecules in promoting vascularisation and introduce nephronectin as an example of a new promising candidate. Finally, we discuss current biomaterial- based approaches including micropatterning, electrospinning, 3D micro-manufacturing technology and porogens. Collectively, the current literature supports the notion that cardiac tissue engineering is a realistic option for future treatment of paediatric and adult patients with cardiac disease.
Incremental Prognostic Value of Left Ventricular Global Longitudinal Strain in Patients With Aortic Stenosis and Preserved Ejection Fraction
Authors: Kusunose Kenya , Goodman Andrew , Parikh Roosha , Barr Tyler , Agarwal Shikhar , Popovic Zoran B. , Grimm Richard A. , Griffin Brian P. , Desai Milind Y. 
Published: October 2014

Background—
We sought to assess the utility of left ventricular global longitudinal strain (LV-GLS) in predicting mortality in moderate to severe and paradoxical severe aortic stenosis (AS) patients with preserved ejection fraction.

Methods and Results—

We studied 395 AS patients (70±14 years, 57% men) with aortic valve area <1.3 cm
2
evaluated between January to June 2008 (excluding severe other valve disease and LV ejection fraction <50%). Clinical and echocardiographic data were recorded. LV-GLS was analyzed using Velocity Vector Imaging. AS patients were classified as (a) moderate–severe (n=93; aortic valve area, 1.1–1.3 cm
2
), (b) standard severe (n=161; aortic valve area, ≤1 cm2; mean gradient ≥40 mm Hg), and (c) paradoxical severe (n=141; aortic valve area, ≤1 cm2 and mean gradient <40 mm Hg). Additive Euroscore was 7±3. The association of LV-GLS with all-cause mortality was assessed after risk-adjustment using Cox proportional hazards models. Median LV-GLS was −14.8% (interquartile range, −17.2%, −12.1%). At 4.4±1.4 years, there were 92 (23%) deaths. On multivariable Cox analysis, additive Euroscore (hazard ratio, 1.19; 1.13–1.27;
P
<0.001), New York Heart Association class (hazard ratio, 1.44; 1.11–1.87;
P
<0.001), AV surgery with time-dependent covariate analysis (hazard ratio, 0.29; 0.19–0.45;
P
<0.001), and LV-GLS (hazard ratio, 1.05; 1.03–1.07;
P
<0.001) were independent predictors of mortality. LV-GLS <−12.1% (4th quartile) was associated with significantly reduced survival. Addition of LV-GLS to clinical parameters (additive Euroscore+New York Heart Association class) led to significant improvement in prediction of mortality (χ
2
increased from 48 to 58;
P
<0.01).

Conclusions—
LV-GLS independently predicts mortality in moderate–severe and severe AS patients with preserved LV ejection fraction, providing incremental prognostic utility, in addition to standard clinical and echocardiographic parameters.
Implicit Agency in Observed Actions: Evidence for N1 Suppression of Tones Caused by Self-made and Observed Actions
Authors: Poonian Simandeep K. , McFadyen Jessica , Ogden Jessica , Cunnington Ross 
Published: October 2014

Abstract
Every day we make attributions about how our actions and the actions of others cause consequences in the world around us. It is unknown whether we use the same implicit process in attributing causality when observing others' actions as we do when making our own. The aim of this research was to investigate the neural processes involved in the implicit sense of agency we form between actions and effects, for both our own actions and when watching others' actions. Using an interval estimation paradigm to elicit intentional binding in self-made and observed actions, we measured the EEG responses indicative of anticipatory processes before an action and the ERPs in response to the sensory consequence. We replicated our previous findings that we form a sense of implicit agency over our own and others' actions. Crucially, EEG results showed that tones caused by either self-made or observed actions both resulted in suppression of the N1 component of the sensory ERP, with no difference in suppression between consequences caused by observed actions compared with self-made actions. Furthermore, this N1 suppression was greatest for tones caused by observed goal-directed actions rather than non-action or non-goal-related visual events. This suggests that top–down processes act upon the neural responses to sensory events caused by goal-directed actions in the same way for events caused by the self or those made by other agents.
The incremental contribution of TOEIC® Listening, Reading, Speaking, and Writing tests to predicting performance on real-life English language tasks
Authors: Powers Donald E. , Powers Andrew 
Published: October 2014

Typically, English language proficiency tests yield multiple scores – usually for each of the four traditional language domains. In order to maximize the usefulness of test scores, they may need to be accompanied by information concerning how they complement one another. Using self-assessments by some 2300 TOEIC test takers, this study aimed to show that language performance in a particular domain (speaking, for instance) can be predicted by using a test that corresponds specifically to that domain (i.e., the TOEIC Speaking test), but also that it can be even better predicted by supplementing domain-related scores with scores (e.g., TOEIC Listening scores) that do not correspond directly to the target domain. The results of a hierarchical linear regression analysis revealed that adding test scores that did not correspond directly to the target performance domain made statistically and practically significant contributions to prediction in the target domain. Thus, more precise estimates of English language proficiency in a specific domain are possible by assessing skills not only in that domain but in other related domains as well.
What preoperative patient-related factors predict inpatient recovery of physical functioning and length of stay after total hip arthroplasty? A systematic review
Authors: Elings J , Hoogeboom TJ , van der Sluis G , van Meeteren NLU 
Published: October 2014

Objective: To identify the preoperative patient-related characteristics predicting inpatient recovery of functioning and/or length of hospital stay after elective primary total hip arthroplasty. Design: A search was conducted of the electronic databases MEDLINE, EMBASE and CINAHL from inception through April 2014. Observational studies were selected for systematic review if they identified clinically relevant preoperative prognostic factors and reported an association between inpatient recovery of physical functioning and/or length of hospital stay. Study participants were adults undergoing an elective primary total hip arthroplasty. Results: Fourteen studies were included, a total of 199,410 individual total hip arthroplasty procedures. Two studies investigated inpatient recovery of physical functioning, no strong level of evidence was found for a relationship between functional recovery and any of the preoperative predictors. Twelve studies investigated the length of hospital stay and reported 19 preoperative prognostic factors. A strong level of evidence suggested that higher scores on the American Society of Anaesthesiologists assessment (OR 3.34 to 6.22, +0.20 days), increased number of comorbidities (RR of 1.10, +0.59 to 1.61 days), presence of heart disease, (RR of 1.59, +0.26 days), and presence of lung disease (RR of 1.30, +0.34 days) were associated with longer lengths of hospital stay following total hip arthroplasty. Conclusion: For the prediction of inpatient recovery of physical functioning no factors with a strong level of evidence were found. For length of stay there was a strong level of evidence for the American Society of Anaesthesiologists score, number of comorbidities, and presence of heart or lung disease.
Preliminary study of dose reduction and image quality of adult pelvic low-dose CT scan with adaptive statistical iterative reconstruction
Authors: Li Wei , Zhang Cheng-Qi , Li Ai-Yin , Deng Kai , Shi Hao 
Published: October 2014

Background Because pelvic computed tomography (CT) is widely used in clinical practice, there are increasing concerns regarding the associated risks of radiation-induced cancer. Therefore, the capability to reduce the CT radiation dose without compromising image quality is desirable. Purpose To assess the radiation dose and image quality of adult pelvic CT using both a routine dose and low radiation dose with filtered back projection (FBP) and adaptive statistical iterative reconstruction (ASIR). Material and Methods Forty-five patients underwent both routine-dose CT with FBP reconstruction and low-dose CT with FBP and 50% ASIR blending ratio (ASIR50) reconstruction, respectively. Three different groups of image data were compared for subjective and objective image quality. CT dose index volume (CTDIvol), dose-length product (DLP), and effective dose (ED) were recorded. Results The resulting CTDIvol, DLP, and ED following low-dose pelvic CT were 10.80 ± 6.0 mGy, 265.0 ± 55.0 mGy.Cm, and 3.97 ± 0.82 mSv, respectively. When compared with the values obtained following routine-dose pelvic CT, the low-dose pelvic CT values decreased by 62%, 55%, and 56%, respectively ( P < 0.001). The results following evaluation of subjective and objective image quality revealed that there was no significant difference ( P > 0.05) between routine-dose CT with FBP, and low-dose CT with ASIR50. However, significant differences were detected between low-dose CT with FBP, routine-dose CT with FBP, and low-dose CT with ASIR50 ( P < 0.01). Conclusion The application of low-dose pelvic CT with ASIR50 could dramatically reduce the radiation dose and substantially improve image quality.
Single chords convey distinct emotional qualities to both naïve and expert listeners
Authors: Lahdelma Imre , Eerola Tuomas 
Published: October 2014

Previous research on music and emotions has been able to pinpoint many structural features conveying emotions. Empirical research on vertical harmony’s emotional qualities, however, has been rare. The main studies in harmony and emotions usually concern the horizontal aspects of harmony, ignoring emotional qualities of chords as such. An empirical experiment was conducted where participants ( N = 269) evaluated pre-chosen chords on a 9-item scale of given emotional dimensions. 14 different chords (major, minor, diminished, augmented triads and dominant, major and minor seventh chords with inversions) were played with two distinct timbres (piano and strings). The results suggest significant differences in emotion perception across chords. These were consistent with notions about musical conventions, while providing novel data on how seventh chords affect emotion perception. The inversions and timbre also contributed to the evaluations. Moreover, certain chords played on the strings scored moderately high on the dimension of ‘nostalgia/longing,’ which is usually held as a musical emotion rising only from extra-musical connotations and conditioning, not intrinsically from the structural features of the music. The role of background variables to the results was largely negligible, suggesting the capacity of vertical harmony to convey distinct emotional qualities to both naïve and expert listeners.
Dijon, ville d’art et capitale de la gastronomie: L’invention d’une image urbaine (1919–1935)
Authors: Poirrier Philippe 
Published: October 2014

Résumé Maire de Dijon de 1919 à 1935, Gaston-Gérard marque profondément la scène municipale locale. Dans une politique qui vise à dynamiser le développement de la ville, le maire de Dijon se distingue, de bien de ses pairs, par la place essentielle qu’il accorde à l’intervention de la ville dans les domaines culturels. Le discours met en scène trois registres complémentaires qui fondent la légitimité de cette action : le rayonnement de la ville ; le renouveau régionaliste et la démocratisation des arts. La création de la Foire gastronomique, en 1921, participe de cette nouvelle image urbaine : « Dijon, ville d’art et capitale de la gastronomie ».
The effect of race on the CYP3A-mediated metabolism of vincristine in pediatric patients with acute lymphoblastic leukemia
Authors: Sims Rosalyn P 
Published: October 2014

Objective The purpose of this preliminary study was to compare racial background and CYP3A distribution in pediatric acute lymphoblastic leukemia patients as it relates to vincristine-related neurotoxicity. Methods Patients with B-precursor acute lymphoblastic leukemia treated at Children’s Hospital of Michigan were eligible to participate in this study. Determination of the CYP3A variant for each patient was done using Qiagen DNA Blood Mini Kit and polymerase chain reaction amplification. Patients were monitored during their leukemia treatment course for vincristine-related neurotoxicity. Results Fifty-four patients were enrolled. Twenty-nine Caucasian patients (81%) and 13 African-American patients (77%) experienced neurotoxicity. CYP3A genotyping was done for 52 patients. Two African-American and two Caucasian patients were homozygous A/A for the CYP3A5*3 polymorphism. Three of these patients (75%) experienced grade 2 neuropathy. Two Caucasian patients and one African-American patient were heterozygous A/G. Two of these patients (66.7%) experienced grade 2 or 3 neuropathy. Thirty-five patients (67.3%) were homozygous for the mutant inactive G/G allele for CYP3A5*3, eight African-American and 27 Caucasian patients. Of these, six of the African-American patients (75%) and 22 of the Caucasian patients (81.5%) experienced neuropathy. Conclusion The CYP3A5*3 genotype causes very low expression of the CYP3A5 protein and hence decreased vincristine metabolism. In this study, patients who expressed CYP3A5*3 had an increased incidence of vincristine-related neurotoxicity. Overall, a greater percentage of Caucasian patients had documented incidences of neurotoxicity. A larger sample size and more detailed gene analysis are needed for future studies.
Knowledge, Attitudes, and Ordering Patterns for Routine HIV Screening among Resident Physicians at an Urban Medical Center
Authors: Bares Sara , Steinbeck Jennifer , Bence Lauren , Kordik Abbe , Acree Mary Ellen , Jih Jane , Farnan Jeanne , Watson Sydeaka , Rasinski Kenneth , Schneider John , Pitrak David 
Published: October 2014

Background: We sought to measure resident physician knowledge of HIV epidemiology and screening guidelines, attitudes toward testing, testing practices, and barriers and facilitators to routine testing. Methods: Resident physicians in internal medicine, pediatrics, obstetrics and gynecology, and emergency medicine were surveyed. Results: Overall response rate was 63% (162 of 259). Half knew details of the HIV screening guidelines, but few follow these recommendations. Less than one-third reported always or usually performing routine testing. A significant proportion reported only sometimes or never screening patients with risk factors. This was despite a strong belief that HIV screening improves patient care and public health. The most common barriers to testing were competing priorities and forgetting to order the test. Elimination of written consent and electronic reminders was identified as facilitators to routine testing. Although an institutional policy assigns responsibility for test notification and linkage of HIV-positive patients to care to the HIV care program, only 29% were aware of this. Conclusions: Few resident physicians routinely screen for HIV infection and some don’t test patients with risk factors. While competing priorities remain a significant barrier, elimination of written consent form and electronic reminders has facilitated testing. Increasing the awareness of policies regarding test notification and linkage to care may improve screening.
The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia
Authors: Van der Meulen Joni , Sanghvi Viraj , Mavrakis Konstantinos , Durinck Kaat , Fang Fang , Matthijssens Filip , Rondou Pieter , Rosen Monica , Pieters Tim , Vandenberghe Peter , Delabesse Eric , Lammens Tim , De Moerloose Barbara , Menten Björn , Van Roy Nadine , Verhasselt Bruno , Poppe Bruce , Benoit Yves , Taghon Tom , Melnick Ari M. , Speleman Frank , Wendel Hans-Guido , Van Vlierberghe Pieter 
Published: October 2014

Key Points
The H3K27me3 demethylase UTX is recurrently mutated in male T-ALL and escapes X-inactivation in female T-ALL blasts and normal T cells. The loss of Utx contributes to T-ALL formation in vivo and UTX inactivation confers sensitivity to H3K27me3 inhibition.
IRAK-4 and MyD88 deficiencies impair IgM responses against T-independent bacterial antigens
Authors: Maglione Paul J. , Simchoni Noa , Black Samuel , Radigan Lin , Overbey Jessica R. , Bagiella Emilia , Bussel James B. , Bossuyt Xavier , Casanova Jean-Laurent , Meyts Isabelle , Cerutti Andrea , Picard Capucine , Cunningham-Rundles Charlotte 
Published: October 2014

Key PointsHuman IRAK-4 and MyD88 deficiencies impair T-independent IgM production, including IgM recognizing bacterial antigens. T-independent IgM impairment by IRAK-4 and MyD88 deficiencies is linked to inadequacy of the IgM+IgD+CD27+ B-cell subset.
Integral inequalities with ‘maxima’ and their applications to Hadamard type fractional differential equations
Authors: Thiramanus Phollakrit , Tariboon Jessada , Ntouyas Sotiris K 
Published: October 2014

AbstractIn this paper, some new integral inequalities with ‘maxima’ are established involving Hadamard integral. Applications to Hadamard fractional differential equations with ‘maxima’ are also presented.MSC:26A33, 26D10, 26D15.
Mean ergodic theorem for semigroups of linear operators in multi-Banach spaces
Authors: Kenari Hassan Morghi , Saadati Reza , Azhini Mahdi , Cho Yeol Je 
Published: October 2014

Abstract
In this paper, by using Rodé’s method, we extend Yosida’s theorem to semigroups of linear operators in multi-Banach spaces.

MSC:39A10, 39B72, 47H10, 46B03.
A rare case of mixed mucinous cystadenoma with serous cystadenoma of the pancreas treated by laparoscopic central pancreatectomy
Authors: Zhang Ren-Chao , Xu Xiao-Wu , Zhou Yu-Cheng , Wu Di , Ajoodhea Harsha , Chen Ke , Mou Yi-Ping 
Published: October 2014

Abstract
Mixed mucinous cystadenoma with serous cystadenoma of the pancreas is rare. There have been only two previous case reports in the English-language literature. We present a case of a 46-year-old woman who was diagnosed with mixed mucinous cystadenoma with serous cystadenoma of the pancreas. Computed tomography and magnetic resonance imaging showed a cystic neoplasm in the dorsal/proximal body of the pancreas with a clear-margin multilocular cavity and enhanced internal septum. The patient underwent laparoscopic central pancreatectomy. The diagnosis of mixed mucinous cystadenoma with serous cystadenoma of the pancreas was confirmed by pathological examination. The patient was followed up for 3 months and there were no signs of recurrence, or pancreatic exocrine or endocrine insufficiency. To the best of our knowledge, this is the first reported case treated by laparoscopic central pancreatectomy.
A comparative study of improvements Pre-filter methods bring on feature selection using microarray data
Authors: Wang Yingying , Fan Xiaomao , Cai Yunpeng 
Published: October 2014

Abstract

Background
Feature selection techniques have become an apparent need in biomarker discoveries with the development of microarray. However, the high dimensional nature of microarray made feature selection become time-consuming. To overcome such difficulties, filter data according to the background knowledge before applying feature selection techniques has become a hot topic in microarray analysis. Different methods may affect final results greatly, thus it is important to evaluate these pre-filter methods in a system way.

Methods
In this paper, we compared the performance of statistical-based, biological-based pre-filter methods and the combination of them on microRNA-mRNA parallel expression profiles using L1 logistic regression as feature selection techniques. Four types of data were built for both microRNA and mRNA expression profiles.

Results
Results showed that pre-filter methods could reduce the number of features greatly for both mRNA and microRNA expression datasets. The features selected after pre-filter procedures were shown to be significant in biological levels such as biology process and microRNA functions. Analyses of classification performance based on precision showed the pre-filter methods were necessary when the number of raw features was much bigger than that of samples. All the computing time was greatly shortened after pre-filter procedures.

Conclusions
With similar or better classification improvements, less but biological significant features, pre-filter-based feature selection should be taken into consideration if researchers need fast results when facing complex computing problems in bioinformatics.