bluuebunny/crossref_metadata_2025_split huggingface dataset:
Central diabetes insipidus (vasopressin deficiency) after surgery for pituitary tumours: a systematic review and meta-analysis
Authors: Fountas Athanasios , Coulden Amy , Fernández-García Silvia , Tsermoulas Georgios , Allotey John , Karavitaki Niki 
Published: July 2024

Abstract

Objective
Central diabetes insipidus or vasopressin deficiency (AVP-D) is the most frequent water balance disorder after transsphenoidal surgery (TSS) with variable prevalence amongst studies. We aimed to determine rates of newly developed transient or permanent AVP-D in patients with pituitary tumours treated with TSS.

Design and Methods
We performed systematic review of Medline, Embase, and Cochrane Library between January 1, 2000 and January 31, 2021 for studies reporting on outcomes for pituitary adenoma, craniopharyngioma, and Rathke's cleft cyst (RCC) after TSS and providing definition of post-operative AVP-D. We pooled the results as proportions with 95% confidence intervals (CIs) using Freeman-Tukey transformation random effects meta-analysis.

Results
From 11 694 studies, 51 were included. Rates of transient or permanent AVP-D were: 17% (95% CI, 13-21) and 3% (95% CI, 2-5) in total group, 16% (95% CI, 12-21) and 2% (95% CI, 2-3) in pituitary adenomas, 31% (95% CI, 24-39) and 30% (95% CI, 22-39) in craniopharyngiomas, and 35% (95% CI, 16-57) and 14% (95% CI, 6-23) in RCCs, respectively. Based on diagnostic criteria, rates of transient or permanent AVP-D were: For hypotonic polyuria, 14% (95% CI, 8-22) and 3% (95% CI, 1-4), for hypotonic polyuria and hypernatraemia, 21% (95% CI, 13-29) and 5% (95% CI, 2-11), and for desmopressin administration, 22% (95% CI, 15-29) and 9% (95% CI, 0-30), respectively.

Conclusions
Following TSS, a small proportion of patients with pituitary adenoma have permanent AVP-D (2%), but prevalence reaches 30% in ones with craniopharyngioma and 14% in those with RCC. Diagnostic criteria for post-operative AVP-D remain variable affecting reported rates of this condition.
Microeukaryote community coalescence strengthens community stability and elevates diversity
Authors: Vass Máté , Székely Anna J , Carlsson-Graner Ulla , Wikner Johan , Andersson Agneta 
Published: July 2024

AbstractMixing of entire microbial communities represents a frequent, yet understudied phenomenon. Here, we mimicked estuarine condition in a microcosm experiment by mixing a freshwater river community with a brackish sea community and assessed the effects of both environmental and community coalescences induced by varying mixing processes on microeukaryotic communities. Signs of shifted community composition of coalesced communities towards the sea parent community suggest asymmetrical community coalescence outcome, which, in addition, was generally less impacted by environmental coalescence. Community stability, inferred from community cohesion, differed among river and sea parent communities, and increased following coalescence treatments. Generally, community coalescence increased alpha diversity and promoted competition from the introduction (or emergence) of additional (or rare) species. These competitive interactions in turn had community stabilizing effect as evidenced by the increased proportion of negative cohesion. The fate of microeukaryotes was influenced by mixing ratios and frequencies (i.e. one-time versus repeated coalescence). Namely, diatoms were negatively impacted by coalescence, while fungi, ciliates, and cercozoans were promoted to varying extents, depending on the mixing ratios of the parent communities. Our study suggests that the predictability of coalescence outcomes was greater when the sea parent community dominated the final community, and this predictability was further enhanced when communities collided repeatedly.
The utility of website-based quality improvement tools for health professionals: a systematic review
Authors: Tran Georgie , Kelly Bridget , Hammersley Megan , Norman Jennifer , Okely Anthony 
Published: July 2024

Abstract
As technology continues to advance, it is important to understand how website-based tools can support quality improvement. Website-based tools refer to resources such as toolkits that users can access and use autonomously through a dedicated website. This review examined how website-based tools can support healthcare professionals with quality improvement, including the optimal processes used to develop tools and the elements of an effective tool. A systematic search of seven databases was conducted to include articles published between January 2012 and January 2024. Articles were included if they were peer reviewed, written in English, based in health settings, and reported the development or evaluation of a quality improvement website-based tool for professionals. A narrative synthesis was conducted using NVivo. Risk of bias was assessed using the Mixed Methods Appraisal Tool. All papers were independently screened and coded by two authors using a six-phase conceptual framework by Braun and Clarke. Eighteen studies met the inclusion criteria. Themes identified were tool development processes, quality improvement mechanisms and barriers and facilitators to tool usage. Digitalizing existing quality improvement processes (n = 7), identifying gaps in practice (n = 6), and contributing to professional development (n = 3) were common quality improvement aims. Tools were associated with the reported enhancement of accuracy and efficiency in clinical tasks, improvement in adherence to guidelines, facilitation of reflective practice, and provision of tailored feedback for continuous quality improvement. Common features were educational resources (n = 7) and assisting the user to assess current practices against standards/recommendations (n = 6), which supported professionals in achieving better clinical outcomes, increased professional satisfaction and streamlined workflow in various settings. Studies reported facilitators to tool usage including relevance to practice, accessibility, and facilitating multidisciplinary action, making these tools practical and time-efficient for healthcare. However, barriers such as being time consuming, irrelevant to practice, difficult to use, and lack of organizational engagement were reported. Almost all tools were co-developed with stakeholders. The co-design approaches varied, reflecting different levels of stakeholder engagement and adoption of co-design methodologies. It is noted that the quality of included studies was low. These findings offer valuable insights for future development of quality improvement website-based tools in healthcare. Recommendations include ensuring tools are co-developed with healthcare professionals, focusing on practical usability and addressing common barriers to enhance engagement and effectiveness in improving healthcare quality. Randomized controlled trials are warranted to provide objective evidence of tool efficacy.
scMicrobe PTA: near complete genomes from single bacterial cells
Authors: Bowers Robert M , Gonzalez-Pena Veronica , Wardhani Kartika , Goudeau Danielle , Blow Matthew James , Udwary Daniel , Klein David , Vill Albert C , Brito Ilana L , Woyke Tanja , Malmstrom Rex R , Gawad Charles 
Published: July 2024

Abstract
Microbial genomes produced by standard single-cell amplification methods are largely incomplete. Here, we show that primary template-directed amplification (PTA), a novel single-cell amplification technique, generated nearly complete genomes from three bacterial isolate species. Furthermore, taxonomically diverse genomes recovered from aquatic and soil microbiomes using PTA had a median completeness of 81%, whereas genomes from standard multiple displacement amplification-based approaches were usually &lt;30% complete. PTA-derived genomes also included more associated viruses and biosynthetic gene clusters.
Distinctive chemotactic responses of three marine herbivore protists to DMSP and related compounds
Authors: Güell-Bujons Queralt , Zanoli Medea , Tuval Idan , Calbet Albert , Simó Rafel 
Published: July 2024

Abstract
Marine planktonic predator–prey interactions occur in microscale seascapes, where diffusing chemicals may act either as chemotactic cues that enhance or arrest predation, or as elemental resources that are complementary to prey ingestion. The phytoplankton osmolyte dimethylsulfoniopropionate (DMSP) and its degradation products dimethylsulfide (DMS) and acrylate are pervasive compounds with high chemotactic potential, but there is a longstanding controversy over whether they act as grazing enhancers or deterrents. Here, we investigated the chemotactic responses of three herbivorous dinoflagellates to point-sourced, microscale gradients of dissolved DMSP, DMS, and acrylate. We found no evidence for acrylate being a chemotactic repellent and observed a weak attractor role of DMS. DMSP behaved as a strong chemoattractor whose potential for grazing facilitation through effects on swimming patterns and aggregation depends on the grazer’s feeding mode and ability to incorporate DMSP. Our study reveals that predation models will fail to predict grazing impacts unless they incorporate chemotaxis-driven searching and finding of prey.
Fate, inducibility, and behavior of Latilactobacillus curvatus temperate phage TMW 1.591 P1 during sausage fermentation
Authors: Ambros Conrad L , Ehrmann Matthias A 
Published: July 2024

Abstract

Aims
Temperate phages insert their genome into the host’s chromosome. As prophages, they remain latent in the genome until an induction event leads to lytic phage production. When this occurs in a starter culture that has been added to food fermentation, this can impair the fermentation success. This study aimed to analyze prophage inducibility in the Latilactobacillus curvatus TMW 1.591 strain during meat fermentation and investigate whether an induction signal before cryopreservation is maintained during storage and can lead to phage-induced lysis after culture activation.

Methods and results
A prophage-free isogenic derivative of the model starter organism, L. curvatus TMW 1.591, was developed as a negative control (L. curvatus TMW 1.2406). Raw meat fermentation was performed with the wild-type (WT) and phage-cured strains. The WT strain produced high numbers of phages (5.2 ± 1.8 × 107 plaque-forming units g−1) in the meat batter. However, the prophage did not significantly affect the meat fermentation process. Induction experiments suggested an acidic environment as a potential trigger for prophage induction. Phage induction by ultraviolet light before strain cryopreservation remains functional for at least 10 weeks of storage.

Conclusions
Intact prophages are active during meat fermentation. However, in this study, this has no measurable consequences for fermentation, suggesting a high resiliency of meat fermentation against phages. Inadequate handling of lysogenic starter strains, even before preservation, can lead to phage introduction into food fermentation and unintended host lysis.
The morphological diagnosis of 2 economically important subterranean termites in Western Indonesia, Coptotermes curvignathus and Coptotermes gestroi (Blattodea, Rhinotermitidae)
Authors: Wikantyoso Bramantyo , Fajar Anugerah , Tarmadi Didi , Himmi Setiawan Khoirul , Yusuf Sulaeman 
Published: July 2024

Abstract
In Indonesia, the control of Coptotermes curvignathus populations as living tree termite pests has been carried out since the early 20th century. Recently, C. curvignathus has been considered the main termite pest and designated as the only species model for wood and wood products resistance tests against subterranean termite attack testing protocol in the Indonesian National Standard (SNI). However, the species distribution range of C. curvignathus has been long questioned as Coptotermes gestroi is commonly reported as a species found in urban areas of Southeast Asian region, particularly in Indonesia. One of the reasons for the species distribution discrepancies is the lack of morphological markers to distinguish both species in the field. Thus, limiting the field inspection effectiveness in termite pest management in Indonesia. This study reexamined and clarified the morphological differences between C. curvignathus and C. gestroi, based on soldier caste. The head shape, mandible shape, and distribution of genal setae on the ventro-anterior head part and pronotum marked the difference between the 2 species. These current results support previous findings of C. curvignathus as the forest dweller while clarifying C. gestroi as the common urban dweller in Indonesia. The putative benefit of morphological features related to the head, mandible, and setae distribution to the defensive adaptation in their common habitat was discussed. Ultimately, the inclusion of C. gestroi into the Indonesian National Standard (SNI) as an alternative species for efficacy tests against subterranean termites is highly recommended.
Geriatric nutritional risk index as a predictor for surgical site infection in malignant musculoskeletal tumours of the trunk
Authors: Shiraishi Sakura , Fujiwara Toshifumi , Nabeshima Akira , Iida Keiichiro , Endo Makoto , Matsumoto Yoshihiro , Oda Yoshinao , Nakashima Yasuharu 
Published: July 2024

Abstract

Background and objective
Surgical site infection (SSI) is common in surgery for malignant musculoskeletal tumours, specifically those arising from the trunk. In this study, we investigated the risk factors for SSI after resection of musculoskeletal tumours of the trunk.

Methods
This retrospective observational study included 125 patients (72 males, 53 females) with musculoskeletal tumours of the trunk in our hospital from 1 April 2008 to 31 August 2023. The incidence of SSI and its risk factors were investigated.

Results
SSI was observed in 26% (32/125), and the median time to SSI was 22 days. On multivariate analysis, the following were identified as risk factors for SSI: tumours arising caudal to Jacoby’s line (hazard ratio [HR] 4.04; P = .0107), soft tissue reconstruction (HR 3.43; P = .0131), and low Geriatric Nutritional Risk Index (GNRI) (HR 0.96; P = .0304). Patients were classified into two risk categories based on GNRI scores: the risk group (GNRI ≤98) and no risk group (&gt;98). The risk group showed a significantly lower overall noninfection survival rate (P = .023).

Conclusion
Tumours arising caudal to Jacoby line, soft tissue reconstruction, and lower GNRI were risk factors for SSI. Preoperative and postoperative nutritional interventions should be considered to improve GNRI.
Single-cell landscape of alternative polyadenylation in human lymphoid hematopoiesis
Authors: Qiang Jiaqi , Yu Shan , Li Jun , Rong Yu , Wang Xiaoshuang , Zhu Yong , Wang Fang 
Published: July 2024

Abstract
Alternative polyadenylation (APA) is an essential post-transcriptional process that produces mature mRNA isoforms by regulating the usage of polyadenylation sites (PASs). APA is involved in lymphocyte activation; however, its role throughout the entire differentiation trajectory remains elusive. Here, we analyzed single-cell 3′-end transcriptome data from healthy subjects to construct a dynamic-APA landscape from hematopoietic stem and progenitor cells (HSPCs) to terminally differentiated lymphocytes. This analysis covered 19973 cells of 12 clusters from five lineages (B cells, CD4+ T cells, CD8+ T cells, natural killer cells, and plasmacytoid dendritic cells). A total of 2364 genes exhibited differential 3′-untranslated region (3′UTR) PAS usage, and 3021 genes displayed differential intronic cleavage during lymphoid differentiation. We observed a global trend of 3′UTR shortening during lymphoid differentiation. Nevertheless, specific events of both 3′UTR shortening and lengthening were also identified within each cluster. The APA patterns delineated three differentiation stages: HSPCs, precursor cells, and mature cells. Moreover, we demonstrated that the conversion of naïve T cells to memory T cells was accompanied by dynamic APA in transcription factor-encoding genes (TCF7 and NFATC2IP), immune function-related genes (BCL2, CD5, CD28, GOLT1B, and TMEM59), and protein ubiquitination-related genes (UBE2G1, YPEL5, and SUMO3). These findings expand our understanding of the underlying molecular mechanisms of APA and facilitate studies on the regulatory role of APA in lymphoid hematopoiesis.
Implications of refugee crisis on public sector healthcare organizations: Empirical observation from Myanmar’s Rohingya refugees in Bangladesh
Authors: Hasan Mohammad Kamrul , Hossain Farhad , Atar Emrah 
Published: July 2024

Abstract
Political crises, like the refugee crisis, present significant challenges to nation-states and public sector entities. The influx of refugees from Myanmar to Bangladesh has intensified over recent decades, notably after severe violence erupted in Myanmar’s Rakhine state on 25 August 2017. This study focuses on public service organizations, aiming to understand the impact of the Rohingya refugee crisis. Using a qualitative approach and drawing on existing literature, the research examines how the crisis affects the capacity of public healthcare providers in Bangladesh. The findings reveal both detrimental and beneficial effects on organizational functioning, including management, resource availability, and absorptive and adaptive capacities. Through data analysis, eight key themes emerge, such as changes in service quality, disease control, resource allocation dynamics, and impacts on professional knowledge, shedding light on the complex repercussions of the Rohingya refugee crisis on public healthcare services in Bangladesh.
Delayed cervical emphysema after thyroidectomy: a case report and a literature overview
Authors: Mevik Kjersti , Tysvær Gunnbjørg , Solli Torill , Osnes Terje 
Published: July 2024

Abstract
Thyroidectomy is a surgery performed due to both benign and malign diseases in the thyroid. The overall complication rate is low, where most of them will appear within the first 24 hours after surgery. However, severe complications can occur as late as 14 days postsurgery. A woman in her late 30’s underwent total thyroidectomy due to Graves' disease. There were no complications until she presented with swelling on her neck 10 days after surgery. She was diagnosed with cervical emphysema and treated with a controlled negative pressure drain until there was no more air leakage. We assumed that the emphysema was due to an occult injury of the trachea. Urgent evaluation and hospitalization are needed if the patient presents with swelling in the neck after thyroidectomy. Surgeons should be aware of this delayed complication, so they are able to inform and manage their patients accordingly.
An Oath for Vengeance? A vendetta with the testimony of the goddess Allāt in an Ancient North Arabian inscription from Jordan
Authors: Hayajneh Hani , Harahsheh Rafe 
Published: July 2024

Abstract
This paper deals with a new Ancient North Arabian (ANA)-Safaitic inscription from the north-eastern basaltic region of Jordan. Its author registers a revenge-taking action for a man called S1 TR. In contrast to the usual type of Safaitic inscriptions that deal with revenge, we encounter here a case of revenge in which the Arabian goddess Allāt is called for s2 hdt ‘testimony’. The onomastic and lexical components, with special focus on the lexeme s2 hdt and its semantic field, are investigated and analyzed in light of the Semitic lexicon.
The great escape: understanding the connection between Ly α emission and LyC escape in simulated JWST analogues
Authors: Choustikov Nicholas , Katz Harley , Saxena Aayush , Garel Thibault , Devriendt Julien , Slyz Adrianne , Kimm Taysun , Blaizot Jeremy , Rosdahl Joki 
Published: July 2024

ABSTRACT
Constraining the escape fraction of Lyman Continuum (LyC) photons from high-redshift galaxies is crucial to understanding reionization. Recent observations have demonstrated that various characteristics of the Ly$\, \alpha$ emission line correlate with the inferred LyC escape fraction ($f_{\rm esc}^{\rm LyC}$) of low-redshift galaxies. Using a data set of 9600 mock Ly$\, \alpha$ spectra of star-forming galaxies at $4.64 \le z \le 6$ from the SPHINX$^{20}$ cosmological radiation hydrodynamical simulation, we study the physics controlling the escape of Ly$\, \alpha$ and LyC photons. We find that our mock Ly$\, \alpha$ observations are representative of high-redshift observations and that typical observational methods tend to overpredict the Ly$\, \alpha$ escape fraction ($f_{\rm esc}^{\rm Ly\, \alpha }$) by as much as 2 dex. We investigate the correlations between $f_{\rm esc}^{\rm LyC}$ and $f_{\rm esc}^{\rm Ly\, \alpha }$, Ly$\, \alpha$ equivalent width ($W_{\lambda }({\rm Ly\, \alpha })$), peak separation ($v_{\rm sep}$), central escape fraction ($f_{\rm cen}$), and red peak asymmetry ($A_f^{\rm red}$). We find that $f_{\rm esc}^{\rm Ly\, \alpha }$ and $f_{\rm cen}$ are good diagnostics for LyC leakage, selecting for galaxies with lower neutral gas densities and less UV attenuation that have recently experienced supernova feedback. In contrast, $W_{\lambda }({\rm Ly\, \alpha })$ and $v_{\rm sep}$ are found to be necessary but insufficient diagnostics, while $A_f^{\rm red}$ carries little information. Finally, we use stacks of Ly$\, \alpha$, H$\, \alpha$, and F150W mock surface brightness profiles to find that galaxies with high $f_{\rm esc}^{\rm LyC}$ tend to have less extended Ly$\, \alpha$ and F150W haloes but larger H$\, \alpha$ haloes than their non-leaking counterparts. This confirms that Ly$\, \alpha$ spectral profiles and surface brightness morphology can be used to better understand the escape of LyC photons from galaxies during the epoch of reionization.
The Lyman-limit photon mean free path at the end of late reionization in the Sherwood–Relics simulations
Authors: Feron Jennifer , Conaboy Luke , Bolton James S , Chapman Emma , Haehnelt Martin G , Keating Laura C , Kulkarni Girish , Puchwein Ewald 
Published: July 2024

ABSTRACT
Recent evidence supporting reionization ending at redshift $z \lesssim 6$ includes the rapid redshift evolution of the mean free path, $\lambda _{\rm mfp}$, for Lyman-limit photons through the intergalactic medium (IGM) at $5\lt z\lt 6$. Here, we investigate $\lambda _{\rm mfp}$ predicted by the Sherwood–Relics suite of hybrid radiation hydrodynamical simulations. Simulations with comoving volumes of $40^{3}\, h^{-3}\rm \, cMpc^{3}$ ($160^{3}\, h^{-3}\rm \, cMpc^{3}$), calibrated to match the observed Ly $\alpha$ forest transmission with a late end to reionization at $z\lt 6$, are consistent with recent $\lambda _{\rm mfp}$ measurements at $z\lt 5.9$, and are $1.2\sigma$ ($1.8\sigma$) above the highest redshift $\lambda _{\rm mfp}$ measurement at $z=5.93$. The majority of the Lyman-limit opacity at the end of reionization is attributable to highly ionized Ly $\alpha$ forest absorbers with neutral hydrogen column densities $N_{\rm HI} \leq 10^{16}$–$10^{17}\rm \, cm^{-2}$. Resolving these systems is critical for capturing the redshift evolution of $\lambda _{\rm mfp}$ during the final stages of reionization. After reionization completes, overdense gas will reduce $\lambda _{\rm mfp}$ by up to 20 per cent around haloes with masses $M_{\rm h}\sim 10^{9}$–$10^{11}h^{-1}\, {\rm M}_{\odot }$, but during reionization ionized bubbles will instead boost $\lambda _{\rm mfp}$ around haloes by up to an order of magnitude when the IGM is as much as 90 per cent neutral by volume. This effect will play an important role in the visibility of Ly $\alpha$ emitting galaxies at $z\gtrsim 10$ discovered with JWST.