bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative analysis of quantitative trait loci for body weight, growth rate and growth curve parameters from 3 to 72 weeks of age in female chickens of a broiler–layer cross
Authors: Podisi Baitsi K , Knott Sara A , Burt David W , Hocking Paul M 
Published: March 2013

Abstract

Background
Comparisons of quantitative trait loci (QTL) for growth and parameters of growth curves assist in understanding the genetics and ultimately the physiology of growth. Records of body weight at 3, 6, 12, 24, 48 and 72 weeks of age and growth rate between successive age intervals of about 500 F2 female chickens of the Roslin broiler-layer cross were available for analysis. These data were analysed to detect and compare QTL for body weight, growth rate and parameters of the Gompertz growth function.

Results
Over 50 QTL were identified for body weight at specific ages and most were also detected in the nearest preceding and/or subsequent growth stage. The sum of the significant and suggestive additive effects for bodyweight at specific ages accounted for 23-43% of the phenotypic variation. A single QTL for body weight on chromosome 4 at 48 weeks of age had the largest additive effect (550.4 ± 68.0 g, 11.5% of the phenotypic variation) and a QTL at a similar position accounted 14.5% of the phenotypic variation at 12 weeks of age. Age specific QTL for growth rate were detected suggesting that there are specific genes that affect developmental processes during the different stages of growth. Relatively few QTL influencing Gompertz growth curve parameters were detected and overlapped with loci affecting growth rate. Dominance effects were generally not significant but from 12 weeks of age they exceeded the additive effect in a few cases. No evidence for epistatic QTL pairs was found.

Conclusions
The results confirm the location for body weight and body weight gain during growth that were identified in previous studies and were consistent with QTL for the parameters of the Gompertz growth function. Chromosome 4 explained a relatively large proportion of the observed growth variation across the different ages, and also harboured most of the detected QTL for Gompertz parameters, confirming its importance in controlling growth. Very few QTL were detected for body weight or gain at 48 and 72 weeks of age, probably reflecting the effect of differences in reproduction and random environmental effects.
Arsenic trioxide inhibits the proliferation of myeloma cell line through notch signaling pathway
Authors: Hu Jiasheng , Huang Xiao , Hong Xiuli , Lu Quanyi , Zhu Xiongpeng 
Published: March 2013

Abstract
Arsenic Trioxide (ATO) has shown remarkable efficacy for the treatment of multiple myeloma (MM). However, the mechanism by which ATO exerts its inhibitory effect on the proliferation of myeloma cells remains to be clarified. We study the inhibitory effect of ATO at various concentrations on the proliferation of the myeloma cell line RPMI 8226 and discussed the molecular mechanism of ATO on myeloma cell line. Our results proved that ATO had a significant dose-dependent and time-dependent inhibitory effect on the expressions of the Notch receptor (Notch1) and Notch ligand (Jag2). Data from the real-time PCR assay showed that the mRNA expression levels of the Jag2 gene and its downstream gene Hes1 were both significantly down-regulated after the myeloma cells were treated with ATO while the expression of the tumor suppressor gene PTEN was up-regulated. These results elucidated the molecular mechanism underlying the ATO mediated inhibition of myeloma cell proliferation. This is the first report on the anti-myeloma activity in myeloma cells through inhibition of the Notch signaling pathway.
Reduction in Surface Contamination with Cyclophosphamide in 30 US Hospital Pharmacies following Implementation of a Closed-System Drug Transfer Device
Authors: Sessink Paul J.M. , Trahan Jason , Coyne Joseph W. 
Published: March 2013

Purpose In a follow-up to a previous study, surface contamination with the antineoplastic drug cyclophosphamide was compared in 30 US hospital pharmacies from 2004 to 2010 following preparation with standard drug preparation techniques or the PhaSeal closed system drug transfer device (CSTD). Methods Wipe samples were taken from biological safety cabinet (BSC) surfaces, BSC airfoils (the front leading edge of the BSC), floors in front of BSCs, and countertops in the pharmacy, and they were analyzed for contamination with cyclophosphamide. Contamination was reassessed after a minimum of 6 months following the implementation of the CSTD. Surface contamination (ng/cm2) was compared between the 2 techniques and between the previous and current test periods and evaluated with the Kruskal-Wallis test. Results With the use of CSTD compared to the standard preparation techniques, a significant reduction in levels of contamination with cyclophosphamide was observed ( P < .0001). Median values for surface contamination with cyclophosphamide were reduced by 86% compared to 95% in the previous study. Conclusions The CSTD significantly reduced, but did not totally eliminate, surface contamination with cyclophosphamide. In addition to other protective measures, increased usage of CSTDs should be employed to help protect health care workers from exposure to hazardous drugs.
Publication Rates of Abstracts Presented at Five National Pharmacy Association Meetings
Authors: Prohaska Emily , Generali Joyce , Zak Kevin , Grauer Dennis 
Published: March 2013

Background Abstract presentations at professional meetings provide a medium for disseminating the findings of scholarly activity. Rates of abstract publication from various biomedical disciplines have been evaluated, with pharmacy noted to be lower than other specialties. Previous research on pharmacy abstract publication rates was conducted for a limited number of professional meetings but has not been assessed using Google Scholar. Objective To determine the full publication rate of abstracts presented at the 2005 American College of Clinical Pharmacy (ACCP) Spring and Annual Meetings, American Pharmacists Association (APhA) Annual Meeting, and American Society of Health-System Pharmacists (ASHP) Summer and Midyear Clinical Meetings. Methods Publication status was assessed for abstracts presented during the 2005 ACCP Spring and Annual Meetings, APhA Annual Meeting, and ASHP Summer and Midyear Clinical Meetings using PubMed and Google Scholar. Data collected included abstract category, study category, practice site, database(s) in which publication appeared, time in months to publication, publication type, and journal of publication. Results Evaluation of 2,000 abstracts presented in 2005 revealed an overall full publication rate of 19.8% (n = 384). Nearly all pharmacy abstracts were published as manuscripts (98.4%; n=378) and indexed in PubMed and Google Scholar (91.9%; n = 353), although a significant percentage were indexed in Google Scholar only (7.8%; n = 30). The mean time to full publication was 16.8 months (SD ±11.9 months). Conclusions Results were consistent with previously reported full publication rates of abstracts from pharmacy association meetings, indicating that abstracts presented at pharmacy meetings continue to have a lower full publication rate than other health disciplines.
Best constants for metric space inversion inequalities
Authors: Buckley Stephen , Hamza Safia 
Published: March 2013

Abstract
For every metric space (X, d) and origin o ∈ X, we show the inequality I
o(x, y) ≤ 2d
o(x, y), where I
o(x, y) = d(x, y)/d(x, o)d(y, o) is the metric space inversion semimetric, d
o is a metric subordinate to I
o, and x, y ∈ X \ {o} The constant 2 is best possible.
Some remarks on the stability of the multi-Jensen equation
Authors: Schwaiger Jens 
Published: March 2013

Abstract
First a stability result of Prager-Schwaiger [Prager W., Schwaiger J., Stability of the multi-Jensen equation, Bull. Korean Math. Soc., 2008, 45(1), 133–142] is generalized by admitting more general domains of the involved function and by allowing the bound to be not constant. Next a result by Cieplinski [Cieplinski K., On multi-Jensen functions and Jensen difference, Bull. Korean Math. Soc., 2008, 45(4), 729–737] is discussed. Finally a characterization of the completeness of a normed space in terms of stability requirements for multi-Jensen functions is presented.
Peripheral nerve blocks give greater hemodynamic stability than general anesthesia for ASA III patients undergoing outpatient knee arthroscopy
Authors: Bergmann Ingo , Heetfeld Maximilian , Crozier Thomas , Schafdecker Hans , Pöschl Rupert , Wiese Cristoph , Popov Aron , Bauer Martin , Hinz Jose 
Published: March 2013

Abstract
Impact of Diabetic Mellitus on the Effect of Streptokinase in Acute Myocardial Infarction Patients
Authors: Uddin Md Faruque , Hoque AK Fazlul 
Published: March 2013

A prospective interventional study was carried out to compare the thrombolytic effect of streptokinase between diabetic and non-diabetic myocardial infarction patients. Out of 187 study subjects with acute ST segment elevation myocardial infarction (STEMI), admitted at coronary care unit, 126 patients were non-diabetic and 61 patients were diabetic. Streptokinase was administered to all patients. Resolution (reduction) of elevated ST segment was evaluated after 90 min of streptokinase administration. Successful reperfusion (=70% ST-resolution) was significantly higher in non-diabetic than diabetic (p<0.001), while failed reperfusion (<30% ST resolution) was significantly higher in diabetic patients (p<0.001). It may be concluded that diabetes mellitus might affect the thrombolytic outcome of acute myocardial infarction patients with diabetes mellitus. DOI: http://dx.doi.org/10.3329/medtoday.v24i1.14108 Medicine TODAY Vol.24(1) 2012 pp.16-19
Individualized Treatment of Hbeag-Negative Chronic Hepatitis B Using Pegylated Interferon-α2A as First-Line and Week-12 HBV Dna/Hbsag Stopping Rule: A Cost-Effectiveness Analysis
Authors: Iannazzo Sergio , Coco Barbara , Brunetto Maurizia R , Rossetti Francesca , Caputo Antonietta , Latour Andrea , Espinos Belen , Bonino Ferruccio 
Published: March 2013

Background Hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB) is the most frequent and difficult-to-treat viral hepatitis worldwide. HBV DNA and hepatitis B surface antigen (HBsAg) serum levels, which help the early identification of non-responders to pegylated interferon (PEG-IFN), prompt more flexible individualized therapeutic strategies exploiting the benefits of both PEG-IFN and nucleoside/nucleotide analogues (NAs). We assessed the cost-effectiveness of week-12 HBV DNA/ HBsAg stopping rule for early interruption and switch to currently most effective NA treatments (entecavir [ETV] or tenofovir disoproxil fumarate [TDF]). Methods A decision-analytic Markov model was developed in the following health-related states: CHB, compensated cirrhosis (CC) and decompensated cirrhosis, hepatocellular carcinoma, liver transplant, post-liver transplant, death, virological response, relapse and HBsAg clearance. Simulated strategies included: ETV/TDF in CHB; ETV/TDF delayed until CC; first-line PEG-IFN followed by switch to ETV/TDF for either patients meeting the week-12 stopping rule or week-48 null-responders/relapsers; and first-line PEG-IFN followed by switch to ETV/TDF delayed until CC. ETV and TDF were considered alternatively for a total of eight strategies. A lifetime simulation horizon was applied. Results Early treatment strategies using NAs with or without first-line PEG-IFN provided the highest results (approximately 22 life-years and 15 quality-adjusted life years [QALYs]). Delayed treatments until cirrhosis development resulted in poorer outcomes. The average per-patient lifetime costs ranged from €33,500 (TDF in CC) to €68,900 (TDF in CHB). Costs using ETV were 20–50% higher. First-line PEG-IFN strategies ranged from dominant (that is, more effective and less costly) to highly cost-effective, although differences in QALYs were always very narrow. Conclusions The cost-effectiveness of antiviral therapy of HBeAg-negative CHB could be improved significantly using first-line PEG-IFN followed by a switch to NAs in either patients meeting the week-12 HBV DNA/HBsAg stopping rule or week-48 non-responders/relapsers.
De Cyclades à Renater
Authors: Schafer Valérie 
Published: March 2013

L’histoire du Réseau National de télécommunications pour la Technologie, l’Enseignement et la Recherche, constitué en Groupement d’Intérêt Public en janvier 1993, débute dans les années 1980, quand des acteurs scientifiques, de manière simultanée mais encore dispersée, commencent à s’organiser en réseaux. C’est poser d’emblée une originalité de Renater : des besoins et réalisations précèdent la mise en place de l’infrastructure nationale. Si, les origines largement universitaires et scientifiques d’Internet aux États-Unis ne sont plus à démontrer, celles d’Internet en France sont plus largement méconnues et demandent à être réévaluées.
De l’hypothèse d’étoiles aussi denses que les noyaux atomiques à la découverte fortuite des pulsars
Authors: Chamel Nicolas 
Published: March 2013

L’identification des naines blanches en tant qu’étoiles extrêmement compactes au début du XXe siècle amena les astrophysiciens à s’interroger sur le destin des étoiles massives. Imprégnés par le développement spectaculaire de la mécanique quantique puis de la physique nucléaire, ils postulèrent l’existence d’astres aussi denses que les noyaux atomiques et composés principalement de neutrons. Activement traquées comme sources de rayons X, ces étoiles à neutrons furent finalement découvertes de manière fortuite sous la forme de pulsars radio à la fin des années 1960. Les étoiles à neutrons font aujourd’hui encore l’objet de nombreuses recherches.
EDGE-pro: Estimated Degree of Gene Expression in Prokaryotic Genomes
Authors: Magoc Tanja , Wood Derrick , Salzberg' Steven L. 
Published: March 2013

Background The expression levels of bacterial genes can be measured directly using next-generation sequencing (NGS) methods, offering much greater sensitivity and accuracy than earlier, microarray-based methods. Most bioinformatics software for estimating levels of gene expression from NGS data has been designed for eukaryotic genomes, with algorithms focusing particularly on detection of splicing patterns. These methods do not perform well on bacterial genomes. Results Here we describe the first software system designed explicitly for quantifying the degree of gene expression in bacteria and other prokaryotes. EDGE-pro (Estimated Degree of Gene Expression in PROkaryotes) processes the raw data from an RNA-seq experiment on a bacterial or archaeal species and produces estimates of the expression levels for each gene in these gene-dense genomes. Software The EDGE-pro tool is implemented as a pipeline of C++ and Perl programs and is freely available as open-source code at http://www.genomics.jhu.edu/software/EDGE/index.shtml .
Transfert du pseudo-coefficient de Kottwitz et formules de caractère pour la série discrète de GL(N) sur un corps local
Authors: Broussous P. 
Published: March 2013

AbstractSoit G le groupe GL(N, F), où F est un corps localement compact et non archimédien. En utilisant la théorie des types simples de Bushnell et Kutzko, ainsi qu'une idée originale d'Henniart, nous construisons des pseudo-coefficients explicites pour les représentations de la série discrète de G. Comme application, nous en déduisons des formules inédites pour la valeur du charactère d'Harish- Chandra de certaines telles représentations en certainséléments elliptiques réguliers.
How Do Interviewers and Children Discuss Individual Occurrences of Alleged Repeated Abuse in Forensic Interviews?
Authors: Brubacher Sonja P. , Malloy Lindsay C. , Lamb Michael E. , Roberts Kim P. 
Published: March 2013

SummaryPolice interviews (n = 97) with 5‐ to 13‐year‐olds alleging multiple incidents of sexual abuse were examined to determine how interviewers elicited and children recounted specific instances of abuse. Coders assessed the labels for individual occurrences that arose in interviews, recording who generated them, how they were used and other devices to aid particularisation such as the use of episodic and generic language. Interviewers used significantly more temporal labels than did children. With age, children were more likely to generate labels themselves, and most children generated at least one label. In 66% of the cases, interviewers ignored or replaced children's labels, and when they did so, children reported proportionately fewer episodic details. Children were highly responsive to the interviewers' language style. Results indicate that appropriately trained interviewers can help children of all ages to provide the specific details often necessary to ensure successful prosecution. Copyright © 2013 John Wiley & Sons, Ltd.
Within‐Pair Consistency in Child Witnesses: The Diagnostic Value of Telling the Same Story
Authors: Vredeveldt Annelies , Wagenaar Willem A. 
Published: March 2013

SummaryJudges and jurors often rely on consistency for assessing veracity. The present study examined the diagnostic value of within‐pair consistency to predict truth‐telling in pairs of children aged 8 to 10 years. Twenty‐three pairs were questioned about one experienced event and one imagined event (which they had discussed before questioning). Within‐pair consistency was significantly higher for experienced events than for imagined events. The diagnostic value of within‐pair consistency to predict truth‐telling was, however, modest: approximately one out of three judgments based on this cue would have been mistaken. Analyses of children's discussions of the imagined events revealed that interview questions about topics that had been discussed before questioning did not effectively discriminate experienced and imagined events, providing support for theoretical assumptions underlying the unanticipated‐question approach. Practical recommendations for police interviewers are provided. Copyright © 2013 John Wiley & Sons, Ltd.
Facile Fabrication of PbS Nanocrystal:C60 Fullerite Broadband Photodetectors with High Detectivity
Authors: Saran Rinku , Nordin Muhammad N. , Curry Richard J. 
Published: March 2013

AbstractHybrid PbS nanocrystal/C60 fullerite photodetectors are fabricated using a simple one‐step drop casting procedure onto pre‐patterned interdigitated electrodes. The devices exhibit a broad spectral response from the near UV through to the near infrared yielding a detectivity, D*, of above 1010 Jones from 400 nm to ≈1050 nm. The ability to further extend the spectral response to wavelengths ≈1350 nm in the near infrared via tuning of the PbS nanocrystal diameter is also demonstrated. The dynamic responses of the devices are presented, exhibiting a fast photocurrent rise time (<40 ns) followed by a long bi‐exponential decay with characteristic lifetimes of τ1 = 5.3 μs ± 0.1 μs and τ2 = 37.8 μs ± 0.7 μs. These devices, which have a detectivity approaching that of commercial detectors, a broader spectral response, and a fast rise time, offer an attractive low‐cost solution for large‐area broadband photodetectors.
Development of Degradable, pH‐Sensitive Star Vectors for Enhancing the Cytoplasmic Delivery of Nucleic Acids
Authors: Durmaz Yasemin Yuksel , Lin Yen‐Ling , ElSayed Mohamed E. H. 
Published: March 2013

AbstractThe report describes the synthesis of degradable, pH‐sensitive, membrane‐destabilizing, star‐shaped polymers where copolymers of hydrophobic hexyl methacrylate (HMA) and 2‐(dimethylamino)ethyl methacrylate (DMAEMA) monomers are grafted from the secondary face of a beta‐cyclodextrin (β‐CD) core via acid‐labile hydrazone linkages using atom transfer radical polymerization. The effect of the graft's molecular weight, HMA/DMAEMA molar ratio, and the fraction of DMAEMA converted to cationic N,N,N‐trimethylaminoethyl methacrylate (TMAEMA) monomers on polymer's transfection capacity is systematically investigated. Results show that all star‐shaped polymers condense anti‐GAPDH silencing RNA (siRNA) into nanosized particles at +/‐ ratio ≤ 4:1. Star polymers with shorter (25kDa) P(HMA‐co‐DMAEMA‐co‐TMAEMA) grafts are more efficient and less cytotoxic than carriers with longer (40kDa) grafts. The results show that increasing the ratio of hydrophobic HMA monomers in graft's composition higher than 50 mole% dramatically reduces polymer's aqueous solubility and abolishes their transfection capacity. Further, retention of DMAEMA monomers in graft's composition provide a buffering capacity that enhanced the endosomal escape and transfection capacity of the polymers. These systematic studies show that β‐CD‐P(HMA‐co‐DMAEMA‐co‐TMAEMA)4.8 polymer with a 25 kDa average graft's molecular weight and a 50/25/25 ratio of HMA/DMAEMA/TMAEMA monomers is the most efficient carrier in delivering the siRNA cargo into the cytoplasm of epithelial cancer cells.
Adsorption isotherm, kinetic and thermodynamic studies of activated carbon prepared from Garcinia mangostana shell
Authors: Kang Yee Li , Toh Seong Khoon See , Monash Purushothaman , Ibrahim Shaliza , Saravanan Pichiah 
Published: March 2013

ABSTRACTIn this study, Garcinia mangostana shell was used to prepare phosphoric acid activated carbon (GMAC). The adsorption studies of the GMAC were carried out using methylene blue as a model dye adsorbate and textile industry effluent. Adsorption studies were conducted in batch mode. Multiple variables affecting adsorption such as contact time, temperature and pH were studied. The optimum conditions for adsorption were found to be contact time of 60 min, temperature 323 K and pH 12. The resultant data were fitted into the Langmuir, Freundlich and Temkin isotherm. The data best fitted the Freundlich model indicating multilayer adsorption onto heterogeneous surface with irregular distribution of adsorption energy and affinity. The rate of adsorption has good correlation with pseudo‐second‐order kinetics, and diffusion models demonstrate that both film and intraparticle diffusion mechanisms are not the sole rate‐limiting step in this particular adsorption. An evaluation of thermodynamic parameters, namely ΔH°, ΔS° and ΔG°, indicates that the adsorption was feasible, spontaneous and endothermic in nature. The low values of ΔH° and ΔG° correspond to physical adsorption. The results reveal that GMAC can be successfully used to remove various types of dye from aqueous solution. © 2013 Curtin University of Technology and John Wiley & Sons, Ltd.