bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of biomarkers of malignancy (IMWG SLiM criteria) in myeloma in a real‐world population: Clinical characteristics, therapy and outcomes from the Australian and New Zealand Myeloma and Related Diseases Registry (ANZ MRDR)
Authors: Ho P. Joy , Moore Elizabeth , Wellard Cameron , Quach Hang , Blacklock Hilary , Harrrison Simon J. , MacDonald Emma‐Jane , McQuilten Zoe K. , Wood Erica M. , Mollee Peter , Spencer Andrew 
Published: July 2024

SummaryA decade after International Myeloma Working Group (IMWG) biomarkers (SLiM criteria) were introduced, this real‐world study examined their impact on diagnosis, therapy and outcomes in myeloma. Using the ANZ MRDR, 3489 newly diagnosed patients from 2013 to 2023, comprising 3232 diagnosed by CRAB (‘CRAB patients’, including 1758 who also satisfied ≥1 SLiM criteria) and 257 by SLiM (‘SLiM patients’) criteria were analysed. CRAB patients had higher R‐ISS and lower performance status, with no difference in cytogenetic risk. SLiM patients had improved progression‐free survival (PFS, 37.5 vs. 32.2 months, hazard ratio [HR] 1.31 [1.08–1.59], p = 0.003), overall survival (80.9 vs. 73.2 months, HR 1.64 [1.26–2.13], p < 0.001) and PFS2 (54.6 vs. 40.3 months, HR 1.51 [1.22–1.86], p < 0.001) compared with CRAB patients, partially explained by earlier diagnosis, with no differential impact between the plasma cell and light‐chain criteria on PFS. However, 34% of CRAB patients did not manifest SLiM characteristics, raising the possibility that SLiM features are associated with different biological behaviours contributing to a better prognosis, for example, improved PFS2 in SLiM patients suggested less disease resistance at first relapse. These data support earlier initiation of therapy by SLiM. The superior survival outcomes of SLiM versus CRAB patients highlight the importance of defining these subgroups when interpreting therapeutic outcomes at induction and first relapse.
Advancements in inhibitors of crucial enzymes in the cysteine biosynthetic pathway: Serine acetyltransferase and O‐acetylserine sulfhydrylase
Authors: Qin Yinhui , Teng Yuetai , Yang Yan , Mao Zhenkun , Zhao Shengyu , Zhang Na , Li Xu , Niu Weihong 
Published: July 2024

AbstractInfectious diseases have been jeopardized problem that threaten public health over a long period of time. The growing prevalence of drug‐resistant pathogens and infectious cases have led to a decrease in the number of effective antibiotics, which highlights the urgent need for the development of new antibacterial agents. Serine acetyltransferase (SAT), also known as CysE in certain bacterial species, and O‐acetylserine sulfhydrylase (OASS), also known as CysK in select bacteria, are indispensable enzymes within the cysteine biosynthesis pathway of various pathogenic microorganisms. These enzymes play a crucial role in the survival of these pathogens, making SAT and OASS promising targets for the development of novel anti‐infective agents. In this comprehensive review, we present an introduction to the structure and function of SAT and OASS, along with an overview of existing inhibitors for SAT and OASS as potential antibacterial agents. Our primary focus is on elucidating the inhibitory activities, structure–activity relationships, and mechanisms of action of these inhibitors. Through this exploration, we aim to provide insights into promising strategies and prospects in the development of antibacterial agents that target these essential enzymes.
Accuracy of navigation guided implant surgery for immediate loading complete arch restorations: Prospective clinical trial
Authors: Pozzi Alessandro , Carosi Paolo , Laureti Andrea , Mattheos Nikos , Pimkhaokham Atiphan , Chow James , Arcuri Lorenzo 
Published: July 2024

AbstractObjectivesTo assess navigation accuracy for complete‐arch implant placement with immediate loading of digitally prefabricated provisional.Materials and MethodsConsecutive edentulous and terminal dentition patients requiring at least one complete‐arch FDP were treated between December 2020 and January 2022. Accuracy was evaluated by superimposing pre‐operative and post‐operative cone beam computed tomography (CBCT), recording linear (mm) and angular (degrees) deviations. T‐tests were performed to investigate the potential effect of the registration algorithm (fiducial‐based vs. fiducial‐free), type of references for the fiducial‐free algorithm (teeth vs. bone screws), site characteristic (healed vs. post‐extractive), implant angulation (axial vs. tilted), type of arch (maxilla vs. mandible) on the accuracy with p‐value <0.05.ResultsTwenty‐five patients, 36 complete‐arches, and 161 implants were placed. The overall mean angular deviation was 2.19° (SD 1.26°). The global platform and apex mean deviations were 1.17 mm (SD 0.57 mm), and 1.30 mm (SD 0.62 mm). Meaningful global platform (p = 0.0009) and apical (p = 0.0109) deviations were experienced only between healed and post‐extraction sites. None of the analyzed variables significantly influenced angular deviation. Minor single‐axis deviations were reported for the type of jaw (y‐axis at implant platform and apex), registration algorithm (y‐axis platform and z‐axis deviations), and type of references for the fiducial‐free algorithm. No statistically significant differences were found in relation to implant angulation.ConclusionsWithin the study limitations navigation was reliable for complete‐arch implant placement with immediate loading digitally pre‐fabricated FDP. AI‐driven surface anatomy identification and calibration protocol made fiducial‐free registration as accurate as fiducial‐based, teeth and bone screws equal as references. Implant site characteristics were the only statistically significant variable with healed sites reporting higher accuracy compared to post‐extractive. Live‐tracked navigation surgery enhanced operator performance and accuracy regardless of implant angulation and type of jaw. A mean safety room of about 1 mm and 2° should be considered.
1104. Dactylorhiza purpurella (T.Stephenson & T.A.Stephenson) Soó
Authors: Fay Michael F. , Raistrick Reinhild 
Published: July 2024

SummaryDactylorhiza purpurella (northern marsh orchid) is illustrated here (t. 1104). It is a north‐western European allotetraploid species, and allotetraploidy and different treatments of the diploid progenitors of this and other allotetraploids in the genus have led to a complicated taxonomic history. A detailed description is provided, with notes on the habitat. Its conservation status has been assessed as Least Concern in Britain, although populations may be at risk from drainage and other agricultural change. It is available for sale from specialist nurseries; notes on cultivation are provided.
Size and financing of external growth strategies among small and medium enterprises
Authors: Chalençon Ludivine , Marion Alain 
Published: July 2024

AbstractThis research analyzes the effects of size on the financial decisions of unlisted small‐ and medium‐sized enterprises (SMEs) engaged in external growth. Among 259 French SMEs that undertook external growth investments, this effort accelerated their growth trajectories when they were able to overcome financial constraints specific to their size. Despite the resulting loss of control, financing of external growth thus requires equity raising. In the specific context of consolidating sectors, in which increasing size is vital, operations can be financed partly by share‐based payments. In this way, targets' owners remain shareholders and benefit from the improved performance brought about by consolidation.
Problematising the Anthropocene: Geographic perspectives upon the riverscapes of Waimatā Catchment, Aotearoa New Zealand
Authors: Thomas Megan , Lythberg Billie , Hikuroa Dan , Brierley Gary 
Published: July 2024

AbstractDrawing on a Critical Physical Geography perspective, this paper problematises conceptualisations of the Anthropocene landscape of the Waimatā catchment on the East Cape, Gisborne district of Aotearoa New Zealand, through three lenses: forestry, restoration and indigeneity. Historical practices of arbitrary land division and resultant unsustainable forestry have caused multiple environmental, social and cultural problems within the catchment. Despite significant efforts of restoration groups and volunteers to remedy this, as yet programmes do not align with holistic Māori ideologies of seeing themselves as the land from which they trace their tribal identity. Fragmentation of the land has disrupted senses of identity and place. A kinship‐based worldview between humans, the universe and everything in it suggests a more holistic lens through which humans are conceived as inseparable from nature. Such a more‐than‐human lens exposes a critical flaw in interpretations of the Anthropocene. Even when only considering its lexical construction, the word ‘Anthropocene’ innately centres the human. Continued use of such framings extends inequitable and unjust practices that imprint colonial forcings on the landscape and its people in ways inconsistent with intertwined Māori views of people, land and ancestors. No matter the lens through which it is interpreted, the Anthropocene term has little practical value in Aotearoa New Zealand, especially when considered in relation to emerging socio‐natural river‐centric perspectives.
Fatty acid preference for beta‐oxidation in mitochondria of murine cultured astrocytes
Authors: Corales Laarni Grace , Inada Hitoshi , Owada Yuji , Osumi Noriko 
Published: July 2024

AbstractThe brain utilizes glucose as a primary energy substrate but also fatty acids for the β‐oxidation in mitochondria. The β‐oxidation is reported to occur mainly in astrocytes, but its capacity and efficacy against different fatty acids remain unknown. Here, we show the fatty acid preference for the β‐oxidation in mitochondria of murine cultured astrocytes. Fatty acid oxidation assay using an extracellular flux analyzer showed that saturated or monosaturated fatty acids, palmitic acid and oleic acid, are preferred substrates over polyunsaturated fatty acids like arachidonic acid and docosahexaenoic acid. We also report that fatty acid binding proteins expressed in the astrocytes contribute less to fatty acid transport to mitochondria for β‐oxidation. Our results could give insight into understanding energy metabolism through fatty acid consumption in the brain.
Quality of life measurement in assessing treatment effectiveness in urticaria: European experts position statement
Authors: Chernyshov Pavel Viktorovich , Tomas‐Aragones Lucia , Zuberbier Torsten , Kocatürk Emek , Manolache Liana , Pustisek Nives , Svensson Åke , Marron Servando E. , Sampogna Francesca , Bewley Anthony , Salavastru Carmen , Koumaki Dimitra , Augustin Matthias , Linder Dennis , Abeni Damiano , Salek Sam S. , Szepietowski Jacek C. , Jemec Gregor B. 
Published: July 2024

AbstractIn this study, the European Academy of Dermatology and Venereology (EADV) Task Forces on Quality of Life and Patient‐Oriented Outcomes and Urticaria and Angioedema has examined the Health‐Related Quality of Life (HRQoL) measurement in the treatment of urticaria. The Dermatology Life Quality Index was the most frequently used HRQoL instrument in clinical trials on urticaria. Many reports of clinical trials of urticaria gave no exact numeric results related to HRQoL changes, making clear conclusions and comparisons with other studies impossible. The interpretation of HRQoL impairment data is more difficult when assessed by instruments without severity stratification systems. The minimal clinically significant difference (MCID) is a more clinically oriented and relevant parameter than depending on statistically significant changes in HRQoL scores. Therefore, using HRQoL instruments with established MCID data in clinical trials and clinical practice is preferred.
Impact of reproductive traits on productive life in Iranian Holstein dairy cows
Authors: Reisi‐Vanani Reza , Ansari‐Mahyari Saeid , Pakdel Abbas , Cue Roger I. 
Published: July 2024

AbstractEnhancing reproductive performance is a key strategy to mitigate involuntary culling rates, thereby extending productive life (PL) and ultimately improving profitability in dairy cattle herds. A piecewise Weibull proportional hazards model was used to investigate the effect of several important reproductive traits on PL in Holstein dairy cows. Data comprised 200,747 lactation records from 82,505 cows sired by 1952 bulls across 36 dairy herds. PL was defined as the number of days from the first calving to the last milk record or censoring. The statistical model accounted for the time‐dependent fixed effects of changes in herd size, year‐season, milk production, fat and protein contents, and the time‐independent fixed effect of age at first calving. Herd‐year and sire effects were also included as random effects. Reproductive traits include calving traits such as calving ease (CE), calf size (CZ), and calf survival (CS), as well as female fertility traits such as number of inseminations per conception (NI), days from calving to first service (CFS), days from first service to conception (FSC), and days open (DO). All reproductive traits had a significant effect on PL (p < 0.001). Each reproductive trait was analysed separately. The relative risk (RR) of being culled increased as the severity of calving difficulties increased in both primiparous and multiparous cows. Cows that calved small or large calves showed a higher risk of being culled compared with those that calved medium size calves. The increased RR of culling was observed only for primiparous cows that gave birth to dead calves. In addition, cows that required more NI, a longer CFS, FSC, and DO had shorter longevity. These insights can deepen our comprehension of the factors affecting PL and provide information for refining management and breeding strategies, which could lead to increased profitability and sustainability in Iranian dairy farming.
Advancement in perioperative management of pituitary adenomas—Current concepts and best practices
Authors: Shafiq Ismat , Williams Zoë R. , Vates G. Edward 
Published: July 2024

AbstractPituitary adenomas are very common representing 18.1% of all brain tumors and are the second most common brain pathology. Transsphenoidal surgery is the mainstay of treatment for all pituitary adenomas except for prolactinomas which are primarily treated medically with dopamine agonists. A thorough endocrine evaluation of pituitary adenoma preoperatively is crucial to identify hormonal compromise caused by the large sellar mass, identifying prolactin‐producing tumors and comorbidities associated with Cushing and acromegaly to improve patient care and outcome. Transsphenoidal surgery is relatively safe in the hands of experienced surgeons, but still carries a substantial risk of causing hypopituitarism that required close follow‐up in the immediate postoperative period to decrease mortality. A multidisciplinary team approach with endocrinologists, ophthalmologists, and neurosurgeons is the cornerstone in the perioperative management of pituitary adenomas.
Differing worldviews: The politics of happiness, meaning, and psychological richness
Authors: Oishi Shigehiro , Choi Hyewon , Cha Youngjae , Heintzelman Samantha , Buttrick Nicholas R , Westgate Erin C 
Published: July 2024

AbstractObjective/BackgroundConservative ideology, broadly speaking, has been widely linked to greater happiness and meaning in life. Is that true of all forms of a good life? We examined whether a psychologically rich life is associated with political orientation, system justification, and Protestant work ethic, independent of two other traditional forms of a good life: a happy life and a meaningful life.MethodParticipants completed a questionnaire that assessed conservative worldviews and three aspects of well‐being (N = 583 in Study 1; N = 348 in Study 2; N = 436 in Study 3; N = 1,217 in Study 4; N = 2,176 in Study 5; N = 516 in Study 6).ResultsHappiness was associated with political conservatism and system justification, and meaning in life was associated with Protestant work ethic. In contrast, zero‐order correlations showed that psychological richness was not associated with conservative worldviews. However, when happiness and meaning in life were included in multiple regression models, the nature of the association shifted: Psychological richness was consistently inversely associated with system justification and on average less political conservatism, suggesting that happiness and meaning in life were suppressor variables.ConclusionsThese findings suggest that happiness and meaning in life are associated with conservative ideology, whereas psychological richness is not.
Management of intrahepatic and perihilar cholangiocarcinomas: Guidelines of the French Association for the Study of the Liver (AFEF)
Authors: Neuzillet Cindy , Decraecker Marie , Larrue Hélène , Ntanda‐Nwandji Line C. , Barbier Louise , Barge Sandrine , Belle Arthur , Chagneau Carine , Edeline Julien , Guettier Catherine , Huguet Florence , Jacques Jérémie , Le Bail Brigitte , Leblanc Sarah , Lewin Maïté , Malka David , Ronot Maxime , Vendrely Véronique , Vibert Éric , Bureau Christophe , Bourliere Marc , Ganne‐Carrie Nathalie , Blanc Jean‐Frédéric 
Published: July 2024

AbstractIntrahepatic cholangiocarcinoma (iCCA) is the second most common malignant primary liver cancer. iCCA may develop on an underlying chronic liver disease and its incidence is growing in relation with the epidemics of obesity and metabolic diseases. In contrast, perihilar cholangiocarcinoma (pCCA) may follow a history of chronic inflammatory diseases of the biliary tract. The initial management of CCAs is often complex and requires multidisciplinary expertise. The French Association for the Study of the Liver wished to organize guidelines in order to summarize the best evidence available about several key points in iCCA and pCCA. These guidelines have been elaborated based on the level of evidence available in the literature and each recommendation has been analysed, discussed and voted by the panel of experts. They describe the epidemiology of CCA as well as how patients with iCCA or pCCA should be managed from diagnosis to treatment. The most recent developments of personalized medicine and use of targeted therapies are also highlighted.
A pilot integrated model nurse clinic increases the uptake of antiviral treatment for the prevention of mother‐to‐child transmission of HBV
Authors: Hui Vicki W. K. , Cheung Alan C. S. , Yip Amber C. W. , Yung Cherry C. T. , Mok Irene H. Y. , Lau Wince Y. P. , Yip Terry C. F. , Lai Mandy S. M. , Lai Jimmy C. T. , Chan Henry L. Y. , Wong Vincent W. S. , Wong Grace L. H. 
Published: July 2024

AbstractBackground and AimsMother‐to‐child‐transmission (MTCT) of hepatitis B virus (HBV) may still occur despite birth‐dose HBV vaccinations when pregnant women are positive for hepatitis B surface antigen (HBsAg) with high viral loads (HBV DNA ≥ 200 000 IU/mL). A pilot integrated model nurse clinic (IMNC) was started in 2020 to implement the pre‐emptive antiviral therapy with tenofovir disoproxil fumarate (TDF). We aimed to evaluate the performance of IMNC on uptake of TDF.MethodsThis was a territory‐wide retrospective cohort of all consecutive HBsAg‐positive women of child‐bearing age with pregnancy records in public hospitals 2019–2022. Demographic characteristics, liver biochemistries and virologic parameters, and TDF use were collected. Concurrently, data from a prospective audit in Union Hospital, the private hospital with the highest number of deliveries in Hong Kong, from June 2022 to May 2023 were compared.ResultsThe prevalence rate of HBV DNA ≥ 200 000 IU/mL in pregnant women with available HBV DNA records was 29.2% (66/226) in 2019, 27.3% (99/363) in 2020, 15.9% (125/784) in 2021 and 17.2% (117/679) in 2022 (p < .001), out of 2052 pregnant women who had their HBV DNA checked within 1 year prior to delivery. An increasing uptake rate of TDF by highly viraemic pregnant women (i.e. ≥ 200 000 IU/mL) was noted after the commencement of IMNC in public hospitals, with 67% (45/67) in 2019, 83% (88/106) in 2020, 91% (117/128) in 2021 and 89% (149/167) in 2022. Moreover, all highly viraemic pregnant women from Union Hospital received TDF. Continuous use of TDF was associated with a reduced risk of postpartum biochemical flare.ConclusionsIMNC increases the uptake of antiviral treatment in pregnant women at risk of MTCT of HBV. IMNC contributes to hepatitis elimination through a structured care plan to prevent MTCT of HBV.
Neopterin, 7,8‐dihydroneopterin, total neopterin levels and their ratio in periodontitis: New dilemma
Authors: Turkmen Emrah , Sayedyousef Hadi , Ucar Dorukhan , Yılmaz Melis , Akdoğan Nihan , Balci Nur , Kurgan Şivge , Toygar Hilal , Serdar Muhittin A. 
Published: July 2024

AbstractObjectiveDetermine the saliva and serum levels of neopterin (NP) and 7,8‐dihydroneopterin (7,8NP) in periodontitis patients and to reveal the relationship of these data with clinical periodontal parameters.Materials and MethodsTwenty‐three patients with stage III/grade B periodontitis and 23 periodontally healthy individuals were included. Clinical periodontal measurements were recorded (plaque index, pocket depth, clinical attachment loss & bleeding on probing). Saliva and serum levels of NP and 7,8NP were analyzed by high‐performance liquid chromatography.ResultsSaliva NP, 7,8NP and Total Neopterin (TNP) levels were significantly elevated in the periodontitis than the control group (p < 0.001).ROC analyses of saliva NP, 7,8NP and TNP yielded areas under the curves of 0.873–0.938 for discriminating periodontitis from health, and saliva TNP was found the most accurate biomarker (AUC = 0.938).There was no significant difference among the periodontitis and control groups for saliva TNP/NP and TNP/7,8NP ratios and serum NP, 7,8NP and TNP levels (p > 0.05).ConclusionIncreased saliva TNP, NP and 7,8NP levels in periodontitis may suggest these biomarkers are regulating immune activation and oxidative stress mechanism in periodontal inflammation. Additionally, together with these results, equivalence of the TNP/NP ratio in intergroups may suggest that the effects of immune activation and oxidative stress mechanisms are equal in the periodontitis.
PSTPIP1‐associated myeloid‐related proteinemia inflammatory (PAMI) syndrome: A case report and review of the literature
Authors: Tran Megan M. , Sprau Pallavi Basu , Moyer Amanda R. , Rieger Kerri E. , Lewis Matthew A. , Hsu Joyce J. , Siegel Dawn H. 
Published: July 2024

AbstractPSTPIP1‐associated myeloid‐related proteinemia inflammatory (PAMI) syndrome is a rare autoinflammatory disorder often arising in pediatric patients. We present a case of an 18‐year‐old female with a past medical history of growth failure, immunoglobulin A nephropathy, and inflammatory arthritis who presented to a pediatric dermatology clinic with findings of acne, psoriasiform dermatitis, and hidradenitis suppurativa, whose clinical, genetic, and laboratory findings were most consistent with PAMI syndrome. We conducted a literature review to better characterize this rare condition in the context of dermatologic findings. Recognition of the distinctive skin findings seen in PAMI syndrome can help distinguish it from other inflammatory disorders, enabling expedited diagnosis and treatment.