bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mesoionic Carbene‐Gold(I) Catalyzed Bis‐Hydrohydrazination of Alkynes with Parent Hydrazine
Authors: Tolentino Daniel R. , Jin Liqun , Melaimi Mohand , Bertrand Guy 
Published: January 2015

AbstractA novel synthetic route gives access to mesoionic carbene and cyclopropenylidene supported gold chloride complexes. The corresponding cationic MIC‐gold complex obtained by chloride abstraction allows for the first transition metal‐catalyzed functionalization of both nitrogens of parent hydrazine.
The molecular mechanism underlying the induction of hepatic MRP3 expression and function by omeprazole
Authors: Pan Yu‐Qin , Mi Qiong‐Yu , He Bang‐Shun , Zhao Shu‐Li , Tai Ting , Xie Hong‐Guang 
Published: January 2015

AbstractPrevious work has indicated that there is increased protein expression of multidrug resistance‐associated protein 3 (MRP3) in the liver samples of patients treated with omeprazole compared with those who were not. However, evidence is still lacking to show the mechanisms underlying that induction. This study aimed to assess changes in the fold‐induction of MRP3 mRNA and protein expression over controls in omeprazole‐treated HepG2 cells after transient transfection of human MRP3 siRNA, or after pretreatment with actinomycin D (Act‐D). Furthermore, MRP3 siRNA knock‐down or MRP‐specific inhibition (indomethacin) was used to determine whether the MRP3 protein induced by omeprazole possessed an enhanced efflux transport. The results demonstrated that omeprazole induced MRP3 mRNA and protein expression in a concentration‐ and time‐dependent manner. Moreover, that induction was almost completely abolished by the addition of human MRP3 siRNA and also by pretreatment with Act‐D, respectively. In addition, the decay rate of MRP3 mRNA in vehicle‐ and omeprazole‐treated cells was similar in the presence of Act‐D, suggesting transcriptional up‐regulation of MRP3 mRNA expression by omeprazole. Most importantly, omeprazole induced MRP3 efflux transport activity, as measured by the 5‐carboxyfluorescein assay in the absence and presence of human MRP3 siRNA or indomethacin. It is concluded that omeprazole can induce MRP3 mRNA and protein expression and enhance MRP3 efflux transport activity through transcriptional up‐regulation, and that omeprazole can also induce other MRP transporters. Copyright © 2015 John Wiley & Sons, Ltd.
Acremoxanthone E, a Novel Member of Heterodimeric Polyketides with a Bicyclo[3.2.2]nonene Ring, Produced by Acremonium camptosporum W. Gams (Clavicipitaceae) Endophytic Fungus
Authors: Meléndez‐González Claudio , Murià‐González M. Jordi , Anaya Ana Luisa , Hernández‐Bautista Blanca E. , Hernández‐Ortega Simón , González María C. , Glenn Anthony E. , Hanlin Richard T. , Macías‐Rubalcava Martha L. 
Published: January 2015

AbstractBioactivity‐directed fractionation of the organic mycelium extract of the endophytic fungus Acremonium camptosporum W. Gams (Clavicipitaceae), isolated from the leaves of Bursera simaruba (Burseraceae), led to the isolation of six major heterodimeric polyketides, including one not previously characterized acremoxanthone derivative. In addition, the already known acremoxanthone C, acremonidins A and B, and acremoxanthones A and B were obtained. The structure of the new compound was established by extensive NMR studies, including DEPT, COSY, NOESY, HSQC, and HMBC methods. The trivial name proposed for this compound is acremoxanthone E. In addition, the structure of acremoxanthone C was unequivocally established for the first time, through X‐ray crystal‐structure analysis. The anti‐oomycete activities of the pure compounds were tested against four economically important phytopathogenic oomycetes. Inhibitory concentration for 50% diameter growth reduction, IC50, values for the four phytopathogens ranged from 6 to 38 μM. Also, in parallel, the cytotoxic activities against six cancer cell lines were evaluated showing IC50 values similar to those of cisplatin. To the best of our knowledge, this is the first report on three different groups of heterodimeric polyketides, linked by a bicyclo[3.2.2]nonene, such as xanthoquinodins, acremonidins, and acremoxanthones, which are isolated from an endophytic fungus. In addition, a common biosynthetic origin could be proposed.
Risk and outcomes of complications during and after MitraClip implantation: Experience in 828 patients from the German TRAnscatheter mitral valve interventions (TRAMI) registry
Authors: Eggebrecht Holger , Schelle Sibylle , Puls Miriam , Plicht Björn , von Bardeleben Ralph Stephan , Butter Christian , May Andreas E. , Lubos Edith , Boekstegers Peter , Ouarrak Taoufik , Senges Jochen , Schmermund Axel 
Published: January 2015

AimsTo analyze risk and outcomes of complications during and after MitraClip implantation using multicenter data from the prospective German Transcatheter Mitral Valve Interventions (TRAMI) registry.Methods and ResultsData of 828 patients (mean age: 76.0 [71–81] years, 327 (40%) females) undergoing MitraClip implantation in Germany between 2010 and 2013 were analyzed. Most patients (85%) underwent elective procedures with on average implantation of 1.4 ± 0.6 clips. Emergent cardiac surgery was not required; a single patient died intraoperatively. During the in‐hospital period, complications occurred in 215 (25.9%) patients, of which 106 (12.8%) were considered major. Major bleeding complications were among the most frequent major complications (7.4%), while rates of pericardial tamponade (1.9%) and clip‐specific complications (embolization: 0%, partial clip detachment: 1.9%) were low. In‐hospital death, stroke or myocardial infarction (MACCE) occurred in 2.2, 0.9, and 0% patients, respectively. Patients with complications appeared to be older and more critically ill pre‐interventionally; in‐hospital mortality was significantly higher as compared to those without procedural complications.ConclusionsMitraClip implantation appears to be a safe treatment option with low rates of MACCE and clip‐specific complications. Nevertheless, MitraClip therapy is not without complications. Careful patient selection and improvements in preventing peri‐procedural bleeding have the potential of reducing post‐procedural complications and improving outcomes. © 2015 Wiley Periodicals, Inc.
Severe leukopenia and thrombocytopenia secondary to quinidine
Authors: Nair M. R. S. , Duvernoy W. F. C. , Leichtman D. A. 
Published: January 2015

AbstractA case of severe thrombocytopenia and leukopenia secondary to quinidine is presented. The white cell count and platelet count returned to normal within five days after initiation of corticosteroid therapy and cessation of quinidine. Of interest is the fact that the patient had developed a purpuric rash twelve months earlier after drinking gin and tonic.
Transient giant R waves in the early phase of acute myocardial infarction: Association with ventricular fibrillation
Authors: Madias J. E. , Krikelis E. N. 
Published: January 2015

AbstractAn unusual electrocardiographic (ECG) pattern was observed in five patients who suffered an acute anterior myocardial infarction. Early in their illness and following resuscitation from ventricular fibrillation (three patients), in the midst of recurrent ventricular irritability prior to development of ventricular fibrillation (one patient), and following a period of seizures (one patient), the ECG showed ST‐segment elevation, marked increase in the R‐wave amplitude, disappearance of S waves and merging of QRS complexes with the elevated ST segments. ECG patterns noted in these patients were similar to the ones recorded from dogs immediately after ligation of a large coronary artery, and from patients with severe episodes of variant angina. Although these early electrocardiographic changes probably reflect either marked regional transmural blood flow deprivation or its aftermath, they could not be taken as indices of eventual massive myocardial necrosis since in most of these patients the alterations were followed by development of nontransmural myocardial infarction. The possible mechanisms and the implications of such discrepancy between early and late electrocardiographic indicators of injury or necrosis is discussed.
Simultaneous contrast imaging of the left ventricle by two‐dimensional echocardiography and standard ventriculography
Authors: Barrett M. J. , Jacobs L. , Gomberg J. , Horton L. , Wolf N. M. , Meister S. G. 
Published: January 2015

AbstractSimultaneous contrast two‐dimensional echocardiograms and contrast ventriculograms were analyzed for 19 cardiac cycles in 6 patients. Ventriculographic volume was underestimated by 40 ± 4.5% (p <.001) by the contrast echocardiograms, despite good correlation (r = 0.88). Discrepancies could not be assigned to changes in volume between studies nor to a lack of precise endocardial definition. Simultaneous imaging demonstrated that the ultrasonic transducer was located 33° cephalad to the cardiac apex. Although angiographic volume was severely underestimated, ejection fraction (r = 0.93) and stroke volume (r = 0.90) could be calculated from two‐dimensional echocardiograms using regression equations.
Cardiovascular function in patients with progressive systemic sclerosis (scleroderma)
Authors: Gaffney F. A. , Anderson R. J. , Nixon J. V. , Blomqvist C. G. , Moore W. E. 
Published: January 2015

AbstractSixteen patients with progressive systemic sclerosis (PSS), including 3 with the “CREST” (calcinosis, Raynaud's, esophageal dysfunction, sclerodactyly, and/or telangiectasias) variant, were evaluated with resting M‐mode echocardiography and noninvasive measurements of cardiac output at rest and during submaximal exercise to determine the nature and extent of any cardiovascular impairment. No patient had arterial hypertension, significant renal impairment, clinical evidence of large vessel coronary artery disease, or severe pulmonary dysfunction. The duration of disease was 1 to 12 years (9 to 30 for patients with the CREST variant). Echocardiographic abnormalities included increased right ventricular dimension (3 patients), reduced left ventricular ejection fraction (3 patients), and pericardial effusion (3 patients). Cardiac index (CI) and stroke volume index (SVI) at rest were similar for patients and controls. Patients and controls were exercised to similar heart rates (130±3 vs 124±4; p, NS). Total peripheral resistance (TPR) was higher for patients (1123±81 vs 810±44 dyn·s·cm−5) and their mean SVI failed to increase significantly compared with sitting rest values (30±2 vs 35±3 ml/m2). The control subjects had the expected increase in SVI (36±2 vs 51 ±5; p < 0.01). Ten patients with an abnormal hemodynamic response to exercise had a normal echocardiographic circumferential fiber shortening (VCF) or ejection fraction (EF) at rest. The data indicate that PSS patients have a greater degree of cardiovascular dysfunction than would be predicted from clinical data and laboratory evaluation of cardiovascular and pulmonary function at rest. Multiple mechanisms, including right and left ventricular dysfunction and abnormal vasoconstrictor activity, are likely to contribute to the reduction in exercise capacity seen in patients with PSS.
Echocardiographic features of aortic ball valve prosthesis malfunction
Authors: Weisburst M. R. , Singh A. K. , Riley R. S. 
Published: January 2015

AbstractA case of aortic ball valve prosthesis malfunction is described in which the poppet became alternately stuck in the open and closed position. The patient experienced chest pain followed by pulmonary edema and cardiac arrest. Malfunction of prosthetic valve was diagnosed on echocardiogram and cardiopulmonary resuscitation was carried out until a Bjork‐Shiley valve could be inserted in place of the faulty prosthesis. At the time of the operation, poppet migration had occurred and the poppet could not be found. Subsequent Bjork‐Shiley aortic valve prosthesis dysfunction was suggested by variation in the intensity of the aortic opening sound and in the duration of the systolic ejection period. Fluoroscopy revealed the missing poppet in the left ventricle. Following surgical removal of the poppet, “normal” Bjork‐Shiley valve function was restored.
Acute amphetamine cardiomyopathy in a drug addict
Authors: O'Neill M. E. , Arnolda L. F. , Coles D. M. , Nikolic G. 
Published: January 2015

AbstractA case of acute left ventricular failure following an intravenous dose of amphetamine is described. The diagnosis was made by right heart catheterization. This is the first description of acute amphetamine cardiomyopathy in the medical literature.
The pathology of hypertension in a tropical environment
Authors: Isaacson C. 
Published: January 2015

AbstractHypertension is very common in blacks and occurs at a younger age than in whites. It behaves in an explosive manner with death occurring frequently from cerebral hemorrhage, uremia or congestive heart failure. Pathologically the majority have essential hypertension. The development of hypertension is related to urbanization and Westernization, as the incidence in rural blacks is low. Despite the high incidence of hypertension, myocardial infarction remains infrequent.
Cardiogoniometry
Authors: Sanz E. , Steger J. P. , Thie W. 
Published: January 2015

AbstractCardiogoniometry is a new method to test heart function. It consists of a simple computerized vectorcardiography with a system of leads derived for the construction of three orthogonal projections. With the aid of these three‐dimensional projections the cardiogoniometer, a microprocessor system, measures and computes the maximal vectors of depolarization (QRS) and repolarization (T). It also fixes the orientation of these two spatial vectors by projection on two planes (frontal and oblique sagittal) and determines the solid angle φ between them. Every third heart beat these five parameters and the preceding beat interval are printed out. In this way, a series of measurements is obtained in which only little disturbances of the signals of cardiac de‐ and repolarization occur. In patients with latent coronary insufficiency an abnormal position of the T vector can be detected long before the standard ECG shows a pathological pattern. Cardiogoniometry can be performed in the consulting room or at the bedside. It is noninvasive, painless, and free of risk. The value and limits of this new method are to be tested in comparison with the ECG and invasive methods in cardiology laboratories.
Serial M‐mode echocardiographic mapping in myocardial infarction: A quantitative evaluation of left ventricular wall motion abnormalities
Authors: Lindvall K. , Erhardt L. , Sjögren A. 
Published: January 2015

AbstractM‐mode echocardiographic (echo) mapping was performed in 44 consecutive patients with a first acute transmural myocardial infarction (AMI). Regional left ventricular wall motion, as reflected by mean systolic wall velocity (V̄), was analyzed in 16 segments on day 1,2, 10, of hospitalization and after one year. Mean systolic wall velocity was significantly reduced (p < 0.05–0.01) in all segments indicated to be infarcted according to ECG. Anteroseptal and anterolateral AMIs showed similar V̄ impairment in anterior segments. In one latero‐apical segment in anterolateral AMI V̄ was significantly lower (p < 0.01), while anteroseptal AMI also showed lower values (p < 0.05) for the midsegment of the middle third of septum. Inferior and inferolateral AMI had similar reductions in V̄ in the inferior segments. In addition depressed wall motion (p < 0.05) was found in one posterior segment in inferior AMI and in two posteroseptal segments in inferolateral AMI. Following the AMI V̄ successively decreased in the 4 central segments in patients with anterior wall infarction during the first 3 days, followed by a significant (p < 0.001) improvement on day 10. No further significant changes were seen after one year. Centrally infarcted segments in inferior AMI showed a minor (p < 0.05) decrease in V̄ from day 1 to day 2, with similar V̄ on day 10. A minor improvement (p < 0.05) was found one year later. Segments adjacent to centrally infarcted segments showed V̄ values similar to infarcted segments during the first 24 hours, followed by rapid improvement in inferior AMI from day 2, with normalization by day 10. Border segments in anterior AMI showed depressed V̄ values during the first 3 days, followed by a normalization by day 10. Noninfarcted segments in patients with inferior AMI showed hyperkinetic wall motion during the first 10 days, with normalization at the one year follow‐up. The changes were moderate though peak V̄ values on days 2 or 3 were significantly higher (p < 0.05) than values one year later. Similarly, wall motion in noninfarcted segments in patients with anterior AMI reached hyperkinetic levels days 3 and 10, which was significantly higher (p < 0.01) than values on days 1, 2, or after one year.
Correlation between calcific aortic stenosis diagnosed by two‐dimensional echocardiography and cardiac catheterization
Authors: Nair C. K. , Aronow W. S. , Sketch M. H. , Mohiuddin S. M. , Stokke K. , Ryschon K. 
Published: January 2015

AbstractThis retrospective study correlates the severity of calcific aortic stenosis determined by two‐dimensional (2‐D) echocardiography with the aortic valve area determined by catheterization in 57 patients. Aortic valve leaflet calcification was diagnosed by cineangiography in 50 (88%) of 57 patients and by 2‐D echo in 57 (100%) of 57 patients (p < 0.025). An agreement between severity of aortic stenosis by catheterization and 2‐D echo occurred in 22 (39%) of 57 patients. Chi‐square and logistic regression analyses showed no correlation between the severity of aortic stenosis and the 2‐D echo variables: left ventricular wall thickness, left ventricular diastolic dimension, left ventricular systolic dimension, aortic root diameter, and left atrial dimension. We conclude that 2‐D echo detects aortic leaflet calcification better than cineangiography. However, the severity of aortic stenosis determined by 2‐D echo correlates poorly with the severity of aortic stenosis determined by cardiac catheterization.
Pulmonary varices, benign congenital anomalies simulating perihilar masses of various etiologies
Authors: Platzker J. , Goldhammer E. , Simon J. , Abinader E. 
Published: January 2015

AbstractPulmonary varices are rare and relatively benign congenital malformations. These localized aneurysmatic dilatations of pulmonary veins drain normally to the left atrium. Their radiological appearance may simulate perihilar masses of neoplastic or granulomatous origin and pulmonary arteriovenous fustulae, thus, potentially leading to diagnostic pitfalls. The diagnosis is made during the venous phase of pulmonary angiography which is always necessary in order to avoid unnecessary surgical procedures. An illustrative case and discussion of the subject is presented herein.
Recurrent coronary artery fistula
Authors: Kostis J. B. , Burns J. J. , Moreyra A. E. , Pichard A. D. 
Published: January 2015

AbstractA patient with a large fistula from the left circumflex coronary artery to the coronary sinus that recurred in spite of proximal and distal ligation is presented. It suggests that ligation is not an adequate procedure for large coronary fistulae. Division and oversewing should be done whenever feasible.
Does alcohol intensify the hemodynamic effects of nitroglycerin?
Authors: Kupari M. , Heikkilä J. , Ylikahri R. 
Published: January 2015

AbstractTo evaluate the combined effects of alcohol and nitroglycerin on cardiovascular hemodynamics, M‐mode echocardiography and sphygmomanometric blood pressure measurements were performed on two groups of normal subjects, before and after the administration of nitroglycerin, both in the sober state and during alcohol intoxication. In the first part of the study, 0.5 mg of nitroglycerin was given sublingually to 10 healthy volunteers 5–10 minutes after they had ingested 1 g/kg body weight of ethanol within a 30‐minute period. Control experiments substituted juice for ethanol. The combined effects of ethanol and nitroglycerin on left ventricular diameters, systolic blood pressure, and wall stress were not significantly different from those of juice and nitroglycerin; heart rate and diastolic blood pressure were increased more (p < 0.01) by ethanol and nitroglycerin. In the second part of the study, 1.0 mg of nitroglycerin was administered to a second group of 10 healthy volunteers, first in the control state and again 60 minutes after the subjects had ingested 1 g/kg body weight of ethanol within a 60‐minute period. Systolic blood pressure and wall stress were significantly lower (p < 0.01) after ethanol and nitroglycerin than after nitroglycerin before ethanol intake. We conclude that the nitroglycerin‐induced reductions in left ventricular preload and afterload are not increased by alcohol during the very early phase of intoxication. However, 1 hour or more after alcohol ingestion nitroglycerin may decrease left ventricular afterload to a level significantly lower than that seen after nitroglycerin in the sober state. These data suggest first, that alcohol does not deprive nitroglycerin of its beneficial hemodynamic effects, and second, that the susceptibility to nitroglycerin‐induced hypotension may be increased during the late phase of intoxication.
Linearly constrained minimum variance spatial filtering for localization of conductivity changes in electrical impedance tomography
Authors: Fernández‐Corazza M. , von Ellenrieder N. , Muravchik C. H. 
Published: January 2015

SummaryWe localize dynamic electrical conductivity changes and reconstruct their time evolution introducing the spatial filtering technique to electrical impedance tomography (EIT). More precisely, we use the unit‐noise‐gain constrained variation of the distortionless‐response linearly constrained minimum variance spatial filter. We address the effects of interference and the use of zero gain constraints. The approach is successfully tested in simulated and real tank phantoms. We compute the position error and resolution to compare the localization performance of the proposed method with the one‐step Gauss–Newton reconstruction with Laplacian prior. We also study the effects of sensor position errors. Our results show that EIT spatial filtering is useful for localizing conductivity changes of relatively small size and for estimating their time‐courses. Some potential dynamic EIT applications such as acute ischemic stroke detection and neuronal activity localization may benefit from the higher resolution of spatial filters as compared to conventional tomographic reconstruction algorithms. Copyright © 2015 John Wiley & Sons, Ltd.
Targeted Treatment of Cancer with Nanotherapeutics Based on Mesoporous Silica Nanoparticles
Authors: Knežević Nikola Ž. , Durand Jean‐Olivier 
Published: January 2015

AbstractThe properties of mesoporous silica nanoparticles (MSN) (biocompatibility, surface area, particle diameter, mesoporous structure, and ease of functionalization) are reviewed regarding their benefits for the construction of cancer‐targeting drug delivery systems, with an overview of literature reports within this research area. Intrinsic properties characteristic of tumor tissues (enhanced permeability and retention effect, overexpressed receptors, and acidic extracellular pH) are further discussed which can be utilized for cancer targeting. Recent literature reports are also accounted concerning MSN‐based cancer targeting that takes advantage of characteristics of the tumor environment and also nanotherapeutics capable of stimulus (acidification, exposure to light irradiation, magnetic field) responsive drug delivery. Finally, gene therapy approaches for cancer treatment and MSN‐based gene delivery vectors are reviewed. The research on mesoporous silicates possesses great potential for the development of complex multipurpose nanotherapeutics for simultaneous application in effective targeted treatment and imaging of cancer tissues.