bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Novel Method for the Synthesis of 4‐(Azol‐5‐yl)‐1,2,3‐triazoles.
Authors: Bakulev V. A. , Efimov I. V. , Belyaev N. A. , Rozin Yu. A. , Volkova N. N. , El'tsov O. S. 
Published: August 2012

AbstractA general and efficient method for the synthesis of the title compounds (V) by cycloaddition of azides to 2‐azolylenamines is presented.
ChemInform Abstract: 2‐Cyano‐6‐(trifluoromethyl)‐4H‐pyran‐4‐one: A Novel Versatile CF3‐Containing Building Block.
Authors: Usachev Boris I. , Obydennov Dmitrii L. , Roeschenthaler Gerd‐Volker , Sosnovskikh Vyacheslav Ya. 
Published: August 2012

AbstractThe highly electrophilic pyrone (II) is used as a building block for a variety of trifluoromethylated heterocycles.
ChemInform Abstract: Green Approaches for the Synthesis of 12‐Aryl‐8,9,10,12‐tetrahydrobenzo[a]xanthen‐11‐ones in Aqueous Media and under Microwave Irradiation in Solventless Conditions.
Authors: Khurana Jitender M. , Lumb Anshika , Pandey Archana , Magoo Devanshi 
Published: August 2012

AbstractThree‐component condensation of dimedone with naphthol and aromatic aldehydes can be carried out either in aqueous media using sulfuric acid catalyst, or under microwave irradiation using solvent‐less conditions.
ChemInform Abstract: Novel Acridinedione Derivatives: Design, Synthesis, SIRT1 Enzyme and Tumor Cell Growth Inhibition Studies.
Authors: Alvala Mallika , Bhatnagar Shubhmita , Ravi Alvala , Jeankumar Variam Ullas , Manjashetty Thimmappa H. , Yogeeswari Perumal , Sriram Dharmarajan 
Published: August 2012

AbstractA library of novel acridinedione derivatives (IV) are synthesized via a microwave‐assisted one‐pot three‐component reaction and evaluated for their in vitro hSIRT1 activity.
ChemInform Abstract: Synthesis of 5‐Substituted Aminopyrrolo[3,4‐b]quinolinones by a Diorganozinc‐Mediated Tandem Alkylation/Cyclization.
Authors: Campbell James B. , Firor Judy W. 
Published: August 2012

AbstractAn ortho‐quinone methide imine, generated in situ, is proposed as reactive intermediate.
ChemInform Abstract: Organocopper‐Mediated Two‐Component SN2′‐Substitution Cascade Towards N‐Fused Heterocycles.
Authors: Chernyak D. , Gevorgyan V. 
Published: August 2012

AbstractThe title compounds are obtained in an efficient reaction of organocuprates with heterocyclic propargyl mesylates which are in situ obtained from the corresponding propargyl alcohols.
ChemInform Abstract: Synthesis of 7,9,10,11‐Tetrahydro‐8H‐chromeno[3,2‐h]quinolin‐8‐ones
Authors: Osyanin V. A. , Osipov D. V. , Klimochkin Yu. N. 
Published: August 2012

Abstractvia reaction of Mannich base (I) with enamines (II)
ChemInform Abstract: Activated Anilide in Heterocyclic Synthesis: Synthesis of New Hydrazo, Dihydropyridazine, Tetrahydropyridine, Dihydropyridine and Pyranopyridine Derivatives.
Authors: Hafiz Ibrahim Saad Abdel , Ramiz Mahmoud Mohamed Mahfouz , Elian Mohamed Ahmed 
Published: August 2012

AbstractTitle compounds with expected biological activities are synthesized starting from propanamide (III) or enaminonitrile (XII), respectively.
ChemInform Abstract: Syntheses of 5‐Amino‐2‐phenyl‐4(3H)‐pyrimidinone Derivatives Starting with Glycine.
Authors: Takahashi Daisuke , Honda Yutaka , Izawa Kunisuke 
Published: August 2012

AbstractThe synthesis of title aminopyrimidinone (IV) is achieved by reaction of sodium hydroxymethyleneglycinate (II) with benzamidine (III).
ChemInform Abstract: Synthesis and Antimicrobial Activity of Some Novel Quinoxalines.
Authors: Soliman A. M. , Amer A. A. 
Published: August 2012

AbstractA variety of new fused and polyfused quinoxaline derivatives is synthesized via intramolecular cyclization reactions of 2‐hydrazino‐3‐chloroquinoxaline (I) or dihydrazinoquinoxaline (XV).
ChemInform Abstract: Catalytic Synthesis and Structure of 2‐Methyl‐1,5‐dihydro‐4,1,3‐benzoxadiazepine.
Authors: Golomba L. , Abele E. , Belyakov S. 
Published: August 2012

AbstractA two‐stage method for the preparation of the novel heterocycle (IV) is developed.
ChemInform Abstract: MCM‐41‐Immobilized Bidentate Nitrogen Platinum Complex: A Highly Efficient and Recyclable Phosphine‐Free Catalytic System for the Hydrosilylation of Olefins.
Authors: Zhang Hean , Liu Jiaqin , Cheng Shaojuan , Cai Mingzhong 
Published: August 2012

AbstractAn MCM‐41‐immobilized bidentate nitrogen platinum complex is shown to be an efficient catalyst for the hydrosilylation of olefins with triethoxysilane.
ChemInform Abstract: Nucleophilic Addition of [(Diethoxyphosphoryl)difluoromethyl]lithium to α,β‐Unsaturated Compounds.
Authors: Cherkupally Prabhakar , Beier Petr 
Published: August 2012

AbstractThe addition of [(diethoxyphosphoryl)difluoromethyl]lithium to various α,β‐unsaturated carbonyl compounds and other Michael acceptors leads to a number of new, structurally diverse 1,4‐addition products having an α,α‐difluorophosphonate moiety.
ChemInform Abstract: Chemoselective Synthesis of Highly Substituted 1,2‐Allenyl Ketones, Furans, and 2‐Alkynyl Ketones from Reaction of Lithium Selenolates with 1‐(1‐Alkynyl)cyclopropyl Ketones and Electrophiles.
Authors: Xu Jianfeng , Zhu Shugao , Wu Luling , Huang Xian 
Published: August 2012

AbstractHomo‐Michael addition of Li selenolates to cyclopropyl ketones and subsequent reaction with electrophiles leads to allenyl or alkynyl ketones or furans.
ChemInform Abstract: Penicacids A‐C, Three New Mycophenolic Acid Derivatives and Immunosuppressive Activities from the Marine‐Derived Fungus Penicillium sp. SOF07.
Authors: Chen Ziming , Zheng Zhihui , Huang Hongbo , Song Yongxiang , Zhang Xuelian , Ma Junying , Wang Bo , Zhang Changsheng , Ju Jianhua 
Published: August 2012

AbstractPenicacid A (I), B (III) and C (II) are isolated together with two known compounds, mycophenolic acid (MPA) and 4′‐hydroxy‐mycophenolic acid.
ChemInform Abstract: Intramolecular Free‐Radical Cyclization Reactions on Pentose Sugars for the Synthesis of Carba‐LNA and Carba‐ENA and the Application of Their Modified Oligonucleotides as Potential RNA Targeted Therapeutics
Authors: Zhou Chuanzheng , Chattopadhyaya Jyoti 
Published: August 2012

AbstractReview: 107 refs.
Analyzing panel count data with a dependent observation process and a terminal event
Authors: Zhao Hui , Li Yang , Sun Jianguo 
Published: August 2012

AbstractPanel count data occur in many fields and a number of approaches have been developed. However, most of these approaches are for situations where there is no terminal event and the observation process is independent of the underlying recurrent event process unconditionally or conditional on the covariates. In this paper, we discuss a more general situation where the observation process is informative and there exists a terminal event which precludes further occurrence of the recurrent events of interest. For the analysis, a semiparametric transformation model is presented for the mean function of the underlying recurrent event process among survivors. To estimate the regression parameters, an estimating equation approach is proposed in which an inverse survival probability weighting technique is used. The asymptotic distribution of the proposed estimates is provided. Simulation studies are conducted and suggest that the proposed approach works well for practical situations. An illustrative example is provided. The Canadian Journal of Statistics 41: 174–191; 2013 © 2012 Statistical Society of Canada
Polar body cytokinesis
Authors: Maddox Amy Shaub , Azoury Jessica , Dumont Julien 
Published: August 2012

AbstractPolar body cytokinesis is the physical separation of a small polar body from a larger oocyte or ovum. This maternal meiotic division shares many similarities with mitotic and spermatogenic cytokinesis, but there are several distinctions, which will be discussed in this review. We synthesize results from many different model species, including those popular for their genetics and several that are more obscure in modern cell biology. The site of polar body division is determined before anaphase, by the eccentric, cortically associated meiotic spindle. Depending on the species, either the actin or microtubule cytoskeleton is required for spindle anchoring. Chromatin is necessary and sufficient to elicit differentiation of the associated cortex, via Ran‐based signaling. The midzone of the anaphase spindle serves as a hub for regulatory complexes that elicit Rho activation, and ultimately actomyosin contractile ring assembly and contraction. Polar body cytokinesis uniquely requires another Rho family GTPase, Cdc42, for dynamic reorganization of the polar cortex. This is perhaps due to the considerable asymmetry of this division, wherein the polar body and the oocyte/ovum have distinct fates and very different sizes. Thus, maternal meiotic cytokinesis appears to occur via simultaneous polar relaxation and equatorial contraction, since the polar body is extruded from the spherical oocyte through the nascent contractile ring. As such, polar body cytokinesis is an interesting and important variation on the theme of cell division. © 2012 Wiley Periodicals, Inc
Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor‐Selective Agonists: Novel Halogenated Analogues of 4‐[1‐(3,5,5,8,8‐Pentamethyl‐5,6,7,8‐tetrahydro‐2‐naphthyl)ethynyl]benzoic Acid (Bexarotene)
Authors: Furmick Julie K. , Kaneko Ichiro , Walsh Angela N. , Yang Joanna , Bhogal Jaskaran S. , Gray Geoffrey M. , Baso Juan C. , Browder Drew O. , Prentice Jessica L. S. , Montano Luis A. , Huynh Chanh C. , Marcus Lisa M. , Tsosie Dorian G. , Kwon Jungeun S. , Quezada Alexis , Reyes Nicole M. , Lemming Brittney , Saini Puneet , van der Vaart Arjan , Groy Thomas L. , Marshall Pamela A. , Jurutka Peter W. , Wagner Carl E. 
Published: August 2012

AbstractThe synthesis of halogenated analogues of 4‐[1‐(3,5,5,8,8‐pentamethyl‐5,6,7,8‐tetrahydro‐2‐naphthyl)ethynyl]benzoic acid (1), known commonly as bexarotene, and their evaluation for retinoid X receptor (RXR)‐specific agonist performance is described. Compound 1 is FDA approved to treat cutaneous T‐cell lymphoma (CTCL); however, bexarotene treatment can induce hypothyroidism and elevated triglyceride levels, presumably by disrupting RXR heterodimer pathways for other nuclear receptors. The novel halogenated analogues in this study were modeled and assessed for their ability to bind to RXR and stimulate RXR homodimerization in an RXRE‐mediated transcriptional assay as well as an RXR mammalian‐2‐hybrid assay. In an array of eight novel compounds, four analogues were discovered to promote RXR‐mediated transcription with EC50 values similar to that of 1 and are selective RXR agonists. Our approach also uncovered a periodic trend of increased binding and homodimerization of RXR when substituting a halogen atom for a proton ortho to the carboxylic acid on 1.
Endobronchial ultrasound fine‐needle aspiration biopsy of pulmonary non–small cell carcinoma with subclassification by immunohistochemistry panel
Authors: Collins Brian T. 
Published: August 2012

AbstractBACKGROUND:With the introduction of new treatment modalities and guidelines, it is important to subclassify primary pulmonary non–small cell carcinoma (NSCCA). Subsequent treatment and testing is dependent on accurate subclassification. Endobronchial ultrasound fine‐needle aspiration (EBUS FNA) is used for primary evaluation and diagnosis, and can provide a cell block for ancillary testing.METHODS:EBUS FNA cases from primary pulmonary NSCCA with an immunohistochemical (IHC) panel performed on a cell block with concomitant surgical pathology biopsy were analyzed. Cell block preparations underwent an IHC panel including monoclonal antibodies for napsin A (nap‐A), thyroid transcription factor (TTF‐1), p63, and cytokeratin 5/6 (CK5/6).RESULTS:A total of 81 cases from 81 patients were identified. Of these, 69 cases (85%) were provided a specific diagnosis of adenocarcinoma (ADCA) or squamous cell carcinoma (SCCA) on the EBUS FNA. In 12 cases (15%), a diagnosis of NSCCA, not otherwise specified was provided. For specific subclassifications, there were 35 ADCA cases, 34 SCCA cases, and 12 NSCCA, not otherwise specified cases. For ADCA, nap‐A showed granular cytoplasmic staining and TTF‐1 nuclear staining. For SCCA, CK5/6 showed cytoplasmic staining and p63 nuclear staining. Surgical pathology concomitant material was present in 29 of 81 cases with 18 correlations and 11 noncorrelations.CONCLUSIONS:With new treatment guidelines for patients with primary pulmonary NSCCA, specific diagnosis is increasingly important. EBUS FNA with cell block provided a specific subclassification of NSCCA in 85% of cases when used in conjunction with a specific IHC panel including nap‐A, TTF‐1, CK5/6, and p63. Cancer (Cancer Cytopathol) 2013. © 2012 American Cancer Society.
Switching Properties of a Spiropyran–Cucurbit[7]uril Supramolecular Assembly: Usefulness of the Anchor Approach
Authors: Nilsson Jesper R. , Parente Carvalho Cátia , Li Shiming , Da Silva José Paulo , Andréasson Joakim , Pischel Uwe 
Published: August 2012

AbstractA nitrospiropyran, which was modified with a cadaverine‐derived anchor, was investigated with respect to its thermally induced isomerizations, hydrolytic stability of the merocyanine form, and photochromic ring closure. The host–guest complexation of the anchor by the cucurbit[7]uril macrocycle, evidenced by absorption titration, NMR spectroscopy, and electrospray ionization mass spectrometry, produced significant improvements of the switching properties of the photochrome: 1) appearance of the merocyanine form about 70 times faster, 2) practically unlimited hydrolytic stability of the merocyanine (two and a half days without any measureable decay), and 3) fast, clean, and fatigue‐resistant photoinduced ring closure back to the spiro form. The importance of an adequate molecular design of the anchor was demonstrated by including control experiments with spiropyrans with a shorter linker or without such structural asset.
The General Assessment of Personality Disorder (GAPD) as an Instrument for Assessing the Core Features of Personality Disorders
Authors: Berghuis Han , Kamphuis Jan H. , Verheul Roel , Larstone Roseann , Livesley John 
Published: August 2012

This study presents a psychometric evaluation of the General Assessment of Personality Disorder (GAPD), a self‐report questionnaire for assessing the core components of personality dysfunction on the basis of Livesley's (2003) adaptive failure model. Analysis of samples from a general (n = 196) and a clinical population (n = 280) from Canada and the Netherlands, respectively, found a very similar two‐component structure consistent with the two core components of personality dysfunction proposed by the model, namely, self‐pathology and interpersonal dysfunction. Moreover, the GAPD discriminated between patients diagnosed with and without Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM‐IV‐TR) personality disorder(s) and demonstrated discriminative power in detecting the severity of personality pathology. Correlations with a DSM‐IV symptom measure and a pathological traits model suggest partial conceptual overlap. Although further testing is indicated, the present findings suggest the GAPD is suitable for assessing the core components of personality dysfunction. It may contribute to a two‐step integrated assessment of personality pathology that assesses both personality dysfunction and personality traits. Copyright © 2012 John Wiley & Sons, Ltd.Key Practitioner Message

The core features of personality disorder can be defined as disorders in the self and in the capacity for interpersonal functioning.
A clinically useful operationalization of disordered functioning of personality is needed to determine the maladaptivity of personality traits.
An integrated assessment of personality (dys)functioning and personality traits provides a more comprehensive clinical picture of the patient, which may aid treatment planning.
Metal‐Free Aerobic Alcohol Oxidation: Intensification under Three‐Phase Flow Conditions
Authors: Aellig Christof , Scholz David , Hermans Ive 
Published: August 2012

AbstractThe selective oxidation of alcohols is a pivotal transformation within industrial and synthetic chemistry. In this contribution we use O2 as terminal oxidant and (H)NOx species as oxygen shuttle in order to mediate the oxidation of primary and secondary alcohols under the influence of a solid acid catalyst. Process optimization and intensification through the use of a continuous three‐phase flow reactor is demonstrated. Space–time yields were found to increase by two orders of magnitude with respect to batch experiments, along with additional gains in selectivity and a decrease of N2O formation.
Development of ionospheric tomography using neural network and its application to the 2007 Southern Sumatra earthquake
Authors: Hirooka Shinji , Hattori Katsumi , Nishihashi Masahide , Kon Shinpei , Takeda Tatsuoki 
Published: August 2012

AbstractAn ionospheric anomaly prior to the 2007 Southern Sumatra earthquake (M8.5) was observed by GPS receivers around the Sumatra islands. In this paper, to investigate the three‐dimensional structure of electron density in the ionosphere, a tomographic approach (Residual Minimization Training Neural Network; RMTNN) has been used. Results of the tomographic approach are consistent with those of the total electron content (TEC) approach. We found that a significant decrease of electron density takes place at altitudes of 250 to 400 km, especially at an altitude of 330 km. But the altitude at which the maximum electron density has been observed remains unchanged. The obtained structure has a region of decreased density of Integrated Electron Content (IEC) in the southwest area (at altitudes of 400 to 550 km) and in the northern area (at altitudes of 250 to 400 km). The global tendency of the decreased electron density expands to the east with higher altitudes and it is concentrated in the southern hemisphere over the epicenter. These results show that the high capability of the RMTNN method can be used for estimation of the ionospheric electron density distribution possibly associated with earthquake. © 2012 Wiley Periodicals, Inc. Electr Eng Jpn, 181(4): 9–18, 2012; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.22298
Ternary Graphene–TiO2–Fe3O4 Nanocomposite as a Recollectable Photocatalyst with Enhanced Durability
Authors: Lin Yue , Geng Zhigang , Cai Hongbing , Ma Lu , Chen Jia , Zeng Jie , Pan Nan , Wang Xiaoping 
Published: August 2012

AbstractWe developed a ternary nanocomposite of graphene–TiO2–Fe3O4 (GTF) as a low‐cost, recollectable, and stable photocatalyst for the degradation of organic dyes. The nanocomposite has been successfully prepared by successively growing TiO2 and Fe3O4 nanoparticles on the reduced graphene oxide (RGO). The as‐synthesized GTF nanocomposite shows higher photocatalytic activity as compared with that of pure TiO2 nanoparticles and can be easily collected from water using a magnet. More importantly, benefiting from the presence of RGO, GTF can suppress the photodissolution behavior of Fe3O4 nanoparticles that usually occurrs in TiO2–Fe3O4 binary nanocomposites, rendering it a highly stable photocatalyst. Furthermore, the GTF nanocomposite works well in different pH environments and is capable of eliminating mixtures of various dyes. In addition, the GTF is also able to degrade the dyes under sunlight. These attractive features make the GTF nanocomposite a promising photocatalyst for practical use in wastewater treatment.
Mineralization of Calcium Carbonates in Cellulose Gel Membranes
Authors: Rauch Marcus W. , Dressler Martina , Scheel Hanne , Van Opdenbosch Daniel , Zollfrank Cordt 
Published: August 2012

AbstractA diffusion‐driven mineralization approach for the fabrication of calcium carbonate on and in regenerated and functionalized cellulose membranes was investigated. Calcium dichloride was used as the cation source. Ammonium carbonate was applied in a gas‐phase diffusion and sodium carbonate in a liquid continuous‐flow setup. Calcium carbonate was obtained solely on the membrane surfaces from the gas‐diffusion approach, whereas by applying continuous‐flow diffusion, crystals were obtained throughout the membranes. The main polymorph was calcite with minor fractions of aragonite. The crystals were assembled from nanometer‐sized building blocks and showed a strong interaction with the cellulose matrix under continuous liquid flow conditions. The cellulose membranes acted as an insoluble template matrix with a rigid and fine mesh of cellulose fibers as superstructure, thereby resulting in a structure‐directing microenvironment for the calcium carbonate mineralization in a confined space.
Sequential Palladium‐Catalysed Direct Arylation Followed by Suzuki Coupling of Bromo‐2‐chloropyridines: Simple Access to a Variety of 2‐Arylpyridines
Authors: Baloch Marya , Roy David , Bensaid Souhila , Guerchais Véronique , Doucet Henri 
Published: August 2012

Abstract2‐Arylpyridines are an important class of ligands for the synthesis of complexes with physical properties. We observed that the use of 3‐, 4‐ or 5‐bromo‐2‐chloropyridines allows the synthesis of a wide variety of heteroarylated 2‐arylpyridines by means of successive direct arylation and Suzuki coupling. For these two reactions, an air‐stable catalyst associated to a cheap and nontoxic base was employed as the catalyst. Moreover, a wide range of heteroarenes and functionalised arylboronic acids could be tolerated.
Titanyl Iodate – A Promising Material for Infrared Nonlinear Optics Showing Structural Similarities with KTP
Authors: Suffren Yan , Gautier‐Luneau Isabelle 
Published: August 2012

AbstractA new nonlinear compound, TiO(IO3)2, was synthesized by the hydrothermal method and characterized by single‐crystal X‐ray diffraction. It crystallizes in the acentric Cmc21 space group with the following lattice parameters: a = 10.222(1) Å, b = 8.254(1) Å, c = 7.277(1) Å, and V = 613.98(13) Å3. The structure has alternating Ti–O bond lengths, short [Ti–O 1.733(12) Å, titanyl bond] and long [Ti–O 2.113(12) Å], as observed in the KTiOPO4 (KTP) material. IR spectroscopy and NLO efficiency studies on a powder sample suggest that TiO(IO3)2 is a good potential NLO material.
CAL‐B‐Catalyzed Acylation of Nucleosides and Role of the Sugar Conformation: An Improved Understanding of the Enzyme‐Substrate Recognition
Authors: Martínez‐Montero Saúl , Fernández Susana , Sanghvi Yogesh S. , Gotor Vicente , Ferrero Miguel 
Published: August 2012

AbstractWe demonstrate that the sugar ring conformation of nucleosides plays a critical role duringCandida antarcticalipase B (CAL‐B) catalyzed acylation. Specifically, the North (N), but not the South (S) nucleoside sugar ring conformation is preferred for efficient binding at the catalytic site. In this study, we used nuclear magnetic resonance (NMR) spectroscopy experiments to establish the sugar ring conformation of nucleosides and performed molecular modeling studies to support the observations. The ribo‐ and 2′‐substituted (OMe, F) nucleosides displaying theN‐conformation undergo rapid and facile acylation compared to the 2′‐deoxynucleosides with theS‐conformation. This study improves our understanding of the critical role that sugar conformation plays in enzyme–substrate recognition during biotransformations using CAL‐B. To the best of our knowledge, this is the first experimental report offering a rationale for the observed selectivity during acylation of nucleosides containing theN‐sugar conformation.