bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH PENERAPAN MODEL COOPERATIVE INTEGRATED READING AND COMPOSITION (CIRC) TERHADAP PENGUASAAN KONSEP SISWA KELAS VII SMPN 09 KOTA BENGKULU PADA MATERI PEMANASAN GLOBAL
Authors: Kasim Hafia Ameliyah , Sutarno Sutarno , Wardana Rendy Wikrama , Uliyandari Mellyta , Yani Ariefa Primair 
Published: July 2024

ABSTRAK

Penelitian ini bertujuan untuk mengetahui Pengaruh Penerapan Model Pembelajaran IPA model pembelajaran Cooperative Integrated Reading and Composition (CIRC), terhadap penguasaan konsep siswa di dalam pembelajaran IPA pada materi pemanasan global. Sampel penelitian diambil menggunakan teknik purposive sampling. Sampel yang digunakan dalam penelitian ini adalah siswa kelas VII C sebagai kelas uji coba (eksperimen) dan siswa kelas VII A sebagai kelas pembanding (kontrol). Jumlah siswa yang terlibat terdiri dari 33 siswa dari kelas VII C dan 34 siswa dari kelas VII A. Jenis penelitian ini adalah Quasi Experiment Research tipe nonequivalent control group design. Instrumen yang digunakan dalam penelitian ini adalah lembar tes penguasaan konsep siswa dan lembar angket respon terhadap model yang diajarkan. Berdasarkan Hasil perhitungan penguasaan konsep dengan menggunakan uji t, diperoleh nilai signifikansi menunjukkan 0,00 < 0,05 sehingga H0 ditolak dan H1 diterima. Hasil perhitungan diperoleh besarnya effect size pada penguasaan konsep menunjukkan bahwa terjadi pengaruh yang sedang. Sehingga dapat ditarik kesimpulan bahwa penggunaan model pembelajaran IPA model pembelajaran Cooperative Integrated Reading and Composition (CIRC) memberikan pengaruh yang signifikan terhadap penguasaan konsep siswa kelas VII C SMPN 09 Kota Bengkulu.

Kata kunci : IPA, Penguasaan Konsep, CIRC, dan Pemanasan Global

ABSTRACT

This study aims to determine the Effect of Applying the Science Learning Model Cooperative Integrated Reading and Composition (CIRC) learning model, on students' mastery of concepts in science learning on global warming material. The research sample was taken using a purposive sampling technique. The samples used in this study were students of class VII C as a trial class (experiment) and students of class VII A as a comparison class (control). The number of students involved consisted of 33 students from class VII C and 34 students from class VII A. The type of this research is Quasi Experiment Research type nonequivalent control group design. The instruments used in this study were student concept mastery test sheets and response questionnaires to the model being taught. Based on the results of calculating mastery of the concept using the t test, a significance value is obtained showing 0.00 < 0.05 so that H0 is rejected and H1 is accepted. The results of the calculations show that the magnitude of the effect size on mastery of the concept indicates that there is moderate influence. So it can be concluded that the use of the Science learning model of the Cooperative Integrated Reading and Composition (CIRC) learning model has a significant influence on the mastery of the concepts of class VII C students of SMPN 09 Bengkulu City.

Key words : Science, Mastery of Concepts, CIRC, and Global Warming
POTENSI DAN PENGEMBANGAN OBYEK WISATA SARAE NDUHA DI DESA SORI TATANGA KECAMATAN PEKAT KABUPATEN DOMPU
Authors: Putra M. Ardian Dwi , Usman Kemas , Bonita Mareta Karlin 
Published: July 2024

Keberadaan obyek wisata alam Sarae Nduha tidak bisa dipungkiri oleh tiap wisatawan yang berkunjung karena memiliki panorama yang indah dan eksotis. Berdasarkan survei awal yang dilakukan peneliti bahwa obyek wisata alam Sarae Nduha masih belum berkembang karena kurangnya fasilitas sarana dan prasarana penunjang wisata serta kurangnya promosi yang dilakukan agar menarik minat pengunjung. tujuan dari penelitian ini adalah untuk mengetahui potensi dan pengembangan obyek wisata Sarae Nduha. Penelitian ini merupakan penelitian deskriptif yang menggunakan metode studi literatur, observasi, wawancara dan Dokumentasi dalam pengumpulan data. Analisis SWOT digunakan untuk menetapkan strategi pengembangan objek wisata ini kedepannya. Berdasarkan hasil analisis SWOT dalam rangka mengetahui potensi dan pengembangan obyek wisata Sarae Nduha, Pembangunan pada sarana dan prasarana penunjang wisata pada obyek wisata Sarae Nduha perlu diperioritaskan karena potensi obyek wisata Sarae Nduha sangat bagus untuk dikembangkan dengan syarat diperbaiki akses jalan yang rusak dan penambahan fasilitas seperti tempat duduk dan atraksi wisata. Pembangunan pada sarana dan prasarana penunjang wisata pada obyek wisata Sarae Nduha perlu diperioritaskan. Sebagai tambahan, beberapa hal perlu diperhatikan antara lain: 1) Pembangunan harus melibatkan masyarakat karena masyarakat adalah patner terdekat pemerintah dalam mengsukseskan pembangunan wisata. 2) Untuk meningkatkan kunjungan wisatawan, promosi harus terus dilakukan. 3) Merealisasikan apa yang telah didapat dari proses analisis SWOT pada penelitian ini
Association between neutrophil-to-lymphocyte ratio and diabetic retinopathy in patients with type 2 diabetes: a cohort study
Authors: Tang Yuchen , Li Li , Li Jialin 
Published: July 2024

BackgroundChronic inflammation is implicated in the development of diabetic retinopathy (DR). The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that has been linked to cardiovascular and diabetic kidney diseases. However, the link between NLR and DR remains unclear. As such, this study investigated the association between NLR and DR in Chinese patients.MethodA total of 857 adults diagnosed with type 2 diabetes mellitus (T2DM) without DR at baseline between 2018 and 2021, from a single center in Ningbo, China, were included. Baseline clinical data, including age, sex, T2DM duration, hypertension, smoking, drinking, glycated hemoglobin level, lipid profile, renal function, and NLR, were recorded and analyzed. Cox proportional hazard regression analysis was used to assess the association between NLR and the risk for incident DR.ResultsDuring a median follow-up of 3.0 years, 140 patients developed DR. The multivariable-adjusted hazard ratio (HR) for incident DR across ascending NLR quartiles (≤1.46 [reference], 1.47–1.90, 1.91–2.45 and &gt; 2.45) were 1.000, 1.327 (95% confidence interval [CI] 0.754–2.334), 1.555 (95% CI 0.913–2.648) and 2.217 (95% CI 1.348–3.649), respectively. For each 1-standard deviation increase in NLR, the risk for DR increased by 29.2% (HR 1.292 [95% CI 1.112–1.501) after adjusting for confounding factors.ConclusionResults revealed that a higher NLR at baseline was associated with an increased risk for incident DR. NLR has the potential to be an inexpensive, reliable, and valuable clinical measure that merits further exploration in future studies.
Risk factors, management, and future fertility of empty follicle syndrome: a retrospective study with real-world data
Authors: Luo Zhuoye , Xu Suxin , Hao Guimin 
Published: July 2024

BackgroundEmpty follicle syndrome (EFS) is a challenging clinical problem. This study aims to identify the risk factors for EFS, to present pregnancy outcomes in both EFS cycle as well as subsequent cycles, and to summarize an effective rescue protocol to improve outcomes.MethodsA retrospective analysis between 2016 and 2020 was conducted at our center. Stricter criteria were applied to diagnose EFS. Logistic regression analysis was used to identify the risk factors for EFS. Further analyses were performed within the EFS cycle to present pregnancy outcomes and to find optimal rescue protocols. Long-term follow-up was conducted until live birth was achieved, covering at least two complete oocyte retrieval cycles.ResultsAmong 14,066 patients, 54 (0.38%) were identified as EFS. Patients with polycystic ovary syndrome (PCOS) had a significantly higher risk of developing EFS than non-PCOS ones (aOR = 2.67; 95% CI, 1.47 to 4.83). Within EFS patients, delaying the second oocyte retrieval by 3–6 h significantly improved the rates of obtaining oocyte (97.4% versus 58.3%, P = 0.002), getting embryo available for transfer (92.3% versus 33.3%, P &lt; 0.001), and pregnancy (48.7% versus 8.3%, P = 0.017) compared to other delayed retrieval times. Overall, 31.5% (17/54) and 46.7% (7/15) EFS patients achieved live birth in the EFS cycle and the future cycle, respectively.ConclusionsPCOS is an independent risk factor for EFS, indicating that longer exposure time to human chorionic gonadotropin (hCG) may be necessary. Delaying the second oocyte retrieval by 3–6 h is an effective rescue protocol for EFS patients to achieve optimal outcomes. EFS in a single cycle does not necessarily indicate future fertility decline, but repeated EFS may result in poor outcomes.
Exploring causal correlations between circulating cytokines and atopic dermatitis: a bidirectional two-sample Mendelian randomization study
Authors: Xuan Zhenquan , Chen Xuanyi , Zhou Weinan , Shen Yihang , Sun Zhe , Zhang Hui , Yao Zhirong 
Published: July 2024

ObjectivesNumerous observational studies have reported associations between circulating cytokines and atopic dermatitis (AD); however, the causal relationships between them remain unclear. To explore the causal correlations and direction of causal effects between AD and levels of 91 circulating cytokines.MethodsTwo-sample Mendelian randomization (MR) analyses were conducted to examine the causal relationships between 91 circulating cytokines and AD using summary statistics from genome-wide association studies (GWAS). Reverse MR analyses were performed to investigate reverse causation. Pleiotropy and heterogeneity tests were conducted to assess the robustness of the findings. Additional transcriptome database and clinical peripheral blood mononuclear cells (PBMCs) samples were utilized to validate the results of MR analyses.ResultsLevels of interleukin (IL)-13, IL-18 Receptor 1, Tumor necrosis factor ligand superfamily member 14 (TNFSF14), TNF-related activation-induced cytokine (TRANCE), C-X-C motif chemokine (CXCL)11, IL-33, TNF-beta and CD5 were suggestively associated with the risk of AD (odds ratio, OR: 1.202, 95% CI: 1.018–1.422, p = 0.030; OR: 1.029, 95% CI: 1.029–1.157, p = 0.004; OR: 1.159, 95% CI: 1.018–1.320, p = 0.026; OR: 1.111, 95% CI: 1.016–1.214, p = 0.020; OR: 0.878, 95% CI: 0.783–0.984, p = 0.025; OR: 0.809, 95% CI: 0.661–0.991, p = 0.041; OR: 0.945, 95% CI: 0.896–0.997, p = 0.038; OR: 0.764, 95% CI: 0.652–0.895, p = 8.26e-04). In addition, levels of cytokines including Axin-1, CXCL5, CXCL10, Oncostatin-M (OSM), Sulfotransferase 1A1 (SULT1A1) and TNFSF14 were suggested to be consequences of AD (Beta: -0.080, p = 0.016; Beta: -0.062, p = 0.036; Beta: -0.066, p = 0.049; Beta: -0.073, p = 0.013; Beta: -0.089, p = 0.008; Beta: -0.079, p = 0.031). IL-13, IL-18R1, TNFSF14, and TRANCE were upregulated in both lesional skin biopsies and PBMCs from AD patients.ConclusionThe study indicates that several cytokines, including IL-13, IL-18R1, TNFSF14, TRANCE, CXCL11, IL-33, TNF-beta, and CD5, are upstream of AD development, whereas a few circulating cytokines are potentially downstream in the development of AD.
Mobile health management among end stage renal disease patients: a scoping review
Authors: Wen Yue , Ruan Yi , Yu Yang 
Published: July 2024

AimsThe health management of end-stage renal disease patients is a complicated process, and mobile health management technology provides a new choice for the health management of end-stage renal disease patients. The scope of clinical studies on mobile health management for patients with end-stage renal disease was reviewed, and found that about mobile health management problems existing in the literature were identified to provide ideas for subsequent mobile health management research.MethodsThe databases Web of Science, PubMed, The Cochrane Library, Embase, CNKI, Wan Fang Data, BMJ, and VIP were systematically searched for studies on Mobile health management among end-stage renal disease in adult and adolescent patients or children undergoing kidney replacement therapy. The search covered the period from the inception of the databases to June 20, 2023. Two independent reviewers conducted the literature screening process. Following eligibility screening, a total of 38 papers were included for data extraction and descriptive analysis.ResultsA total of 38 studies from 14 countries were finally included. The majority of which were interventional trials. The platforms used in these studies included remote monitoring systems, apps, websites, mobile phones or tablets, and social platforms. These platforms provided patients with a wide range of services, including disease management, behavioral intervention, social support, and follow-up care. Most studies focused on patient clinical indicators, patient experience, quality of life, and healthcare costs.ConclusionOur findings that mobile health management has been widely used in disease management of end-stage renal disease patients, with rich management content and many evaluation indicators. Future studies should strengthen the evaluation of patients’ mental health, quality of life, and healthcare costs. Additionally, developing a clinical decision support system would enable mobile health management to play a more effective role in end-stage renal disease patients.
Prevalence of co-trimoxazole resistance among HIV-infected individuals in Ethiopia: a systematic review and meta-analysis
Authors: Assefa Muluneh , Girmay Getu 
Published: July 2024

BackgroundCo-trimoxazole is used as a prophylaxis for human immunodeficiency virus (HIV) patients to prevent opportunistic infections. Its widespread use results in the emergence of co-trimoxazole resistance, which is a significant problem. This systematic review and meta-analysis determined the pooled prevalence of co-trimoxazole resistance among HIV-infected individuals in Ethiopia.MethodsThe Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline was applied to report this study. The protocol has been registered in the International Prospective Register of Systematic Reviews (PROSPERO) under the assigned number CRD42024532240. Article search was performed using electronic databases such as PubMed, Medline, EMBASE, Google Scholar, Hinari, Web of Science, Science Direct, and African Journals Online. Data were extracted using a Microsoft Excel spreadsheet and analyzed using STATA version 11.0 software. A random-effects model was used to estimate the pooled effect size of co-trimoxazole resistance across studies with a 95% confidence interval. The heterogeneity was checked using I2 statistic. The presence of publication bias was determined using a funnel plot and Egger’s test with a p-value &lt;0.05 evidence of statistically significant bias. Subgroup and sensitivity analyses were performed.ResultsTwenty-two studies with 5,788 HIV-infected individuals were included. The pooled prevalence of co-trimoxazole resistance was 61.73% (95% CI: 53.10–70.37%), with heterogeneity (I2 = 87.7%) and statistical significance (p &lt; 0.001). A higher co-trimoxazole resistance was observed in HIV-infected individuals with urinary tract infection; 82.10% (95% CI: 75.03–89.17%). Among the bacterial spp., higher resistance to co-trimoxazole was observed in Escherichia coli; 70.86% (95% CI: 53.44–88.27%) followed by Salmonella spp.; 67.66% (95% CI: 41.51–93.81%) and Proteus spp.; 66.23% (95% CI: 34.65–97.82%).ConclusionThere is a higher prevalence of co-trimoxazole resistance in HIV-infected individuals in Ethiopia. This alarms WHO’s recommendation of co-trimoxazole prophylaxis guidelines to review and update it. Additionally, a nationwide assessment of co-trimoxazole resistance in Ethiopia as a whole is required.Systematic review registration: identifier: CRD42024532240.
Colostrum avoidance and associated factors among mothers of less than 6-month-old children in Dilla town, Southern Ethiopia
Authors: Gashaw Anteneh , Kebede Daniel , Regasa Teferi , Bekele Hermela 
Published: July 2024

BackgroundColostrum, often referred to as “golden milk,” is the initial milk produced after birth, crucial for preventing childhood malnutrition and boosting natural immunity. Neglecting colostrum intake heightens vulnerability to infections and mortality, particularly in developing regions of the world. Colostrum avoidance is prevalent in Ethiopia. This research aims to investigate the frequency and factors that contribute to colostrum avoidance in Dilla town, Southern Ethiopia.MethodA community-based, cross-sectional study was carried out in late 2023. Data were gathered from 350 participants, selected through multistage sampling, using structured questionnaires and face-to-face interviews. Data entry was conducted using Epi Data version 4.2.0 and transferred to Stata version 18 for analysis. Bivariate and multivariable logistic regression analyses were employed to identify the factors associated with colostrum avoidance, with a significance level of p &lt; 0.05.ResultThe rate of prevalence of colostrum avoidance was 28.3% [95% confidence interval (CI): 18.4%–38.2%]. Late initiation of breastfeeding [adjusted odds ratios (AOR) 4.15, 95% CI: 2.51–6.84] prelacteal feeding, non-use of postnatal care (PNC) (AOR 1.79, 95% CI: 1.05–3.04), and lack of information about colostrum (AOR 1.88, 95% CI: 1.14–3.08) were the factors significantly associated with colostrum avoidance.Conclusions and recommendationsA high prevalence of colostrum avoidance was observed, with prelacteal feeding, delayed initiation of breastfeeding, lack of PNC, and inadequate maternal knowledge about colostrum identified as contributing factors. Consequently, interventions aimed at reducing colostrum avoidance should prioritize improving access to and promotion of PNC, promoting timely initiation of breastfeeding, and intensifying awareness campaigns highlighting the advantages of colostrum, while emphasizing the risks associated with prelacteal feeding.
Propolis attenuates diabetes-induced testicular injury by protecting against DNA damage and suppressing cellular stress
Authors: Ashour Ahmed M. 
Published: July 2024

Introduction: Propolis has a wide range of biological and pharmacological actions, including antioxidant properties—particularly its phenolic and flavonoid constituents—that could potentially protect the reproductive system from oxidative damage.Method: Four groups were allocated 40 male Wistar rats each. The vehicle was given to the first group’s normal control rats negative control. The second, third, and fourth groups of diabetic rats were given vehicle (diabetic control) and propolis orally at 50 and 100 mg/kg, respectively, for 8 weeks. Diabetes was induced in rats via injection of nicotinamide and streptozotocin (STZ). Fasting blood glucose (FBG) and insulin levels, homeostatic model assessment for insulin resistance (HOMA-IR), and semen analysis were assessed. In addition, assessments of serum reproductive hormones, including total testosterone (TTST), estradiol (E2), follicle-stimulating hormone luteinizing hormone (LH), and prolactin (PRL), were measured at the end of the study. Tissue total testosterone, E2, and dihydrotestosterone were also evaluated. Serum and tissue oxidative enzymes, including catalase (CAT), superoxide dismutase, and glutathione peroxidase activities, were examined, and malondialdehyde content was determined. The pancreatic and testicular tissues were histopathologically examined, and proliferating cell nuclear antigen (PCNA) and B-cell lymphoma 2 (Bcl-2) in testicular tissue were immunohistochemically analyzed. Testicular tissue was examined for DNA integrity using a comet assay.Results: Compared to the STZ-control group, propolis greatly decreased FBG levels and improved the glycemic status of diabetic rats. In comparison to the STZ-DC group, propolis increased the number of sperm cells and the percent of morphologically normal and viable sperm in male rats, improving their fertility. Propolis also restored the pancreatic islets, protected the testis from oxidative stress, and increased levels of reproductive hormones in the blood, especially testosterone. Moreover, propolis at high doses demonstrated a strong positive response for Bcl-2 and a negative expression of proliferating cell nuclear antigen in spermatogenic cells.Conclusion: The data obtained strongly indicate that STZ causes severe impairments to the testis whereas propolis, acting as an antioxidant, protects against the adverse effects of STZ on the testis.
Potassium and zinc improves physiological performance, nutrient use efficiency, and productivity of wheat
Authors: Nawaz Abeer , Bashir Muhammad Amjad , Ahmed Wazir , Ahmad Ijaz , Rehim Abdur , Ikram Rao Muhammad , Shah Syed Shahid Hussain , Khurshid Muhammad Yasir , Rusan Munir Jamil , Lubani Rashid , Saleem Shahzad , Haq Tanveer Ul , Ali Muhammad Asif 
Published: July 2024

Despite the critical role of balanced nutrition in crop productivity, the use of potash (K) and zinc (Zn) is not much practiced by Pakistani farmers. The reduced nutrient uptake and crop productivity together increase the costs associated with fertilization and revisit farmers’ confidence in the efficacy and profitability of fertilizers. To address this problem, a field study was conducted in the research area of the MNS-University of Agriculture, Multan, in collaboration with Engro Fertilizers Limited. The research plan consisted of five treatments, including T1 = control (without N, P, K, and Zn fertilizers), T2 = NP in practice (NP at 32–23–0 kg acre-1), T3 = recommended NP (NP at 48–34.5 kg acre-1), T4 = balanced NPK (NP+K at 48–34.5–30 kg acre-1), and T5 = balanced NPK + Zn (NPK+Zn at 48–34.5–30 + 7.5 kg acre-1). Wheat was used as a test crop, and its growth, yield, and physiological and nutritional parameters were studied. The results indicated that NPK+Zn balanced nutrition increased plant height, spike length, photosynthetic rate, water use efficiency, transpiration rate, stomatal conductance, and grain yield by 13%, 15%, 44%, 60%, 63%, 39%, and 78%, respectively, compared with the control. It was found that the combined application of NP, K, and Zn improved the recovery efficiency of applied nutrients, i.e., nitrogen recovery efficiency (NRE) by 230%, phosphorus recovery efficiency (PRE) by 136%, potassium recovery efficiency (KRE) by 135%, and zinc recovery efficiency (ZnRE) by 136% compared to NP-alone application. Agronomic use efficiency of applied fertilizers, such as potassium agronomic use efficiency (KAUE) by 71%, phosphorus agronomic use efficiency (PAUE) by 72%, nitrogen agronomic use efficiency (NAUE) by 70%, and zinc agronomic use efficiency (ZnAUE) by 72%, was observed compared to NP-alone application. The results showed that NPUE, PPUE, NPUE, and ZnPUE were reduced by 5%, 3%, 3%, and 5%, respectively, compared to NP-alone application. Our findings suggest that K and Zn should be made an essential part of wheat nutrition management for higher yield and better quality of produce.