bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Withholding Angiotensin Receptor Blockers in the Early Postoperative Period and 30-day Mortality
Authors: Lee Susan M. , Takemoto Steven , Wallace Arthur W. 
Published: June 2015

AbstractAbstract
In a review of over 30,000 inpatient surgical admissions of patients taking angiotensin receptor blockers (ARBs) in the Veterans Affairs Healthcare system between 1991 and 2011, ARBs were not resumed by day 2 after surgery in one third of subjects. Thirty-day mortality was increased approximately 50% in those without resumption of ARBs, and this effect was even greater in patients younger than 60 yr.
Supplemental Digital Content is available in the text.

Background:
Despite widespread use, there is limited information to guide perioperative management of angiotensin receptor blockers (ARBs).

Methods:
In this retrospective cohort study, the authors evaluated the patterns of postoperative ARB use in veterans regularly prescribed ARBs admitted for noncardiac surgery at the Veterans Affairs Healthcare system between 1999 and 2011. Multivariable and propensity score–matched Cox proportional hazards models were used to determine the independent effect of failure to resume ARB by postoperative day 2 on the primary outcome of all-cause 30-day mortality.

Results:
Out of 1,167,482 surgical admissions, 30,173 inpatient surgical admissions met inclusion criteria. Approximately 10,205 patients (33.8%) in the cohort did not resume ARB by day 2. Those that resumed ARB had a 30-day mortality rate of 1.3% (260 of 19,968), whereas 3.2% (323 of 10,205) died in the group that withheld ARB. The unadjusted hazard ratio (HR) for 30-day mortality was 2.45 (95% CI, 2.08 to 2.89; P < 0.001) for those that withheld ARB compared with those that resumed, whereas the multivariable adjusted HR was 1.74 (95% CI, 1.47 to 2.06; P < 0.001). When restricted to a propensity score–matched subset of 19,490, the HR was similar (1.47; 95% CI, 1.22 to 1.78; P < 0.001). Withholding ARB in younger patients increased mortality risk (HR = 2.52; 95% CI, 1.69 to 3.76; P < 0.001 for age <60 yr) compared with older patients (HR = 1.42; 95% CI, 1.09 to 1.85; P = 0.01 for age >75 yr).

Conclusions:
Postoperative delay in resuming ARB is common, particularly in patients who are frail after surgery. Withholding ARB is strongly associated with increased 30-day mortality, especially in younger patients, although residual confounding may be present.
Esophageal pH Monitoring in Children
Authors: Nowak Jan K. , Jonczyk‐Potoczna Katarzyna , Adamczak Daria M. , Lisowska Aleksandra , Walkowiak Jaroslaw 
Published: June 2015

ABSTRACTCorrect pH probe placement is vital for the precision of esophageal pH monitoring. This study aimed at finding the optimal formula for placement of pH probe in the locus proposed by the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition European Pediatric Impedance Working Group, that is, 2 vertebrae above the diaphragm. An analysis of data regarding 353 children ages 0–18 years in whom the position of the pH sensor was determined radiographically revealed that a mathematical formula (3.2 + 0.2 × body length or height, centimeter) could guide the probe to within 1/12 of thoracic spine length of the desired location in 71.7% of all of the patients.
P‐Selectin (CD62P) Expression in Liver Tissue of Biliary Atresia
Authors: Sira Mostafa M. , Sira Ahmad M. , Ehsan Nermine A. , Mosbeh Asmaa 
Published: June 2015

ABSTRACTObjectives:The etiology of biliary atresia (BA) is still elusive. Inflammation plays a key role in bile duct and liver injury. The recruitment and accumulation of inflammatory cells is largely dependent on adhesion molecules. We aimed to investigate P‐selectin (CD62P) expression in liver tissue in patients with BA compared with other neonatal cholestatic disorders.Methods:The study included 63 infants with neonatal cholestasis in 2 groups: BA group (n = 32) and non‐BA group (n = 31) with non‐BA cholestatic disorders as controls. Demographic, clinical, laboratory, ultrasonographic, and histopathological parameters were collected. P‐selectin immunostaining was performed. Immunostaining in bile duct epithelium, cellular infiltrate, and vascular endothelial cells were scored as positive or negative.Results:The frequency of P‐selectin–positive endothelium, platelets, and bile duct epithelium was significantly higher in the BA group (72%, 72%, and 63%, respectively) than in the non‐BA group (32%, 16%, and 13%, respectively) with P of 0.002, <0.0001, and <0.0001, respectively. Few mononuclear cellular infiltrates in portal tract expressed P‐selectin and were comparable in both groups (P = 0.932). Of interest, the platelet count was significantly higher in the BA group (532 ± 172) than in the non‐BA group (406 ± 158), and 68.8% of the BA group had thrombocytosis versus 25% in the controls (P = 0.001 for both).Conclusions:The significant expression of P‐selectin in endothelium, platelets, and bile duct epithelium in patients with BA suggests a potential role for this adhesion molecule in the pathogenesis of this devastating neonatal hepatic disorder. It further suggests that platelets in BA are activated and may have a role in the inflammatory process in BA.
A semi-supervised approach uncovers thousands of intragenic enhancers differentially activated in human cells
Authors: González-Vallinas Juan , Pagés Amadis , Singh Babita , Eyras Eduardo 
Published: June 2015

AbstractBackgroundTranscriptional enhancers are generally known to regulate gene transcription from afar. Their activation involves a series of changes in chromatin marks and recruitment of protein factors. These enhancers may also occur inside genes, but how many may be active in human cells and their effects on the regulation of the host gene remains unclear.ResultsWe describe a novel semi-supervised method based on the relative enrichment of chromatin signals between 2 conditions to predict active enhancers. We applied this method to the tumoral K562 and the normal GM12878 cell lines to predict enhancers that are differentially active in one cell type. These predictions show enhancer-like properties according to positional distribution, correlation with gene expression and production of enhancer RNAs. Using this model, we predict 10,365 and 9,777 intragenic active enhancers in K562 and GM12878, respectively, and relate the differential activation of these enhancers to expression and splicing differences of the host genes.ConclusionsWe propose that the activation or silencing of intragenic transcriptional enhancers modulate the regulation of the host gene by means of a local change of the chromatin and the recruitment of enhancer-related factors that may interact with the RNA directly or through the interaction with RNA binding proteins. Predicted enhancers are available athttp://regulatorygenomics.upf.edu/Projects/enhancers.html
Evolution of ecological dominance of yeast species in high-sugar environments
Authors: Williams Kathryn M. , Liu Ping , Fay Justin C. 
Published: June 2015

AbstractIn budding yeasts, fermentation in the presence of oxygen evolved around the time of a whole genome duplication (WGD) and is thought to confer dominance in high-sugar environments because ethanol is toxic to many species. While there are many fermentative yeast species, onlySaccharomyces cerevisiaeconsistently dominates wine fermentations. In this study, we use co-culture experiments and intrinsic growth rate assays to examine the relative fitness of non-WGD and WGD yeast species across environments to assess whenS. cerevisiae’s ability to dominate high-sugar environments arose. We show thatS. cerevisiaedominates nearly all other non-WGD and WGD species except for its sibling speciesS. paradoxusin both grape juice and a high-sugar rich medium. Of the species we tested,S. cerevisiaeandS. paradoxushave evolved the highest ethanol tolerance and intrinsic growth rate in grape juice. However, the ability ofS. cerevisiaeandS. paradoxusto dominate certain species depends on the temperature and the type of high-sugar environment. Our results indicate that dominance of high-sugar environments evolved much more recently than the WGD, most likely just prior to or during the differentiation ofSaccharomycesspecies, and that evolution of multiple traits contributes toS. cerevisiae’s ability to dominate wine fermentations.
Ethylene-Mediated Regulation of A2-Type CYCLINs Modulates Hyponastic Growth in Arabidopsis
Authors: Polko Joanna K. , van Rooij Jop A. , Vanneste Steffen , Pierik Ronald , Ammerlaan Ankie M.H. , Vergeer-van Eijk Marleen H. , McLoughlin Fionn , Gühl Kerstin , Van Isterdael Gert , Voesenek Laurentius A.C.J. , Millenaar Frank F. , Beeckman Tom , Peeters Anton J.M. , Marée Athanasius F.M. , van Zanten Martijn 
Published: June 2015

Abstract
Upward leaf movement (hyponastic growth) is frequently observed in response to changing environmental conditions and can be induced by the phytohormone ethylene. Hyponasty results from differential growth (i.e. enhanced cell elongation at the proximal abaxial side of the petiole relative to the adaxial side). Here, we characterize Enhanced Hyponasty-d, an activation-tagged Arabidopsis (Arabidopsis thaliana) line with exaggerated hyponasty. This phenotype is associated with overexpression of the mitotic cyclin CYCLINA2;1 (CYCA2;1), which hints at a role for cell divisions in regulating hyponasty. Indeed, mathematical analysis suggested that the observed changes in abaxial cell elongation rates during ethylene treatment should result in a larger hyponastic amplitude than observed, unless a decrease in cell proliferation rate at the proximal abaxial side of the petiole relative to the adaxial side was implemented. Our model predicts that when this differential proliferation mechanism is disrupted by either ectopic overexpression or mutation of CYCA2;1, the hyponastic growth response becomes exaggerated. This is in accordance with experimental observations on CYCA2;1 overexpression lines and cyca2;1 knockouts. We therefore propose a bipartite mechanism controlling leaf movement: ethylene induces longitudinal cell expansion in the abaxial petiole epidermis to induce hyponasty and simultaneously affects its amplitude by controlling cell proliferation through CYCA2;1. Further corroborating the model, we found that ethylene treatment results in transcriptional down-regulation of A2-type CYCLINs and propose that this, and possibly other regulatory mechanisms affecting CYCA2;1, may contribute to this attenuation of hyponastic growth.
Explore the feasibility of adopting crowdsourcing for innovative problem solving
Authors: Lee C.K.M. , Chan CY , Ho Sophie , Choy KL , Ip WH 
Published: June 2015

Purpose– The purpose of this paper is to explore the feasibility of adopting crowdsourcing for enhancing innovative problem solving through task design on task attributes. Task attributes have been proven to be an important factor influencing participation and engagement of crowdworkers.Design/methodology/approach– A survey questionnaire was developed and data from potential and experienced crowdworkers was collected and analyzed to identify the influence of task attributes on the quantity and quality of innovative solutions from crowds. This study finds that extrinsic and intrinsic motivation of task attributes are linked to psychological participation attention and the contribution of innovative solutions.Findings– It is found that crowdsourcing projects with higher awards and recognition as extrinsic motivation is positively associated with the quantity of solution. Competitive selection with performance feedback, problems with diversity of knowledge and job autonomy with more information from sponsors are positive associate with the quality of innovative solutions. These results can complement existing research studies on how task attributes influence the performance of existing crowdworkers in crowdsourcing and can also be a starting point for analyzing potential crowdworkers’ psychological perspectives.Originality/value– The novelty of this paper is that it illustrates the influential effects of five selected task attributes – monetary rewards and recognition, competitive selection, knowledge diversity, task complexity and autonomy – to enhance extrinsic and intrinsic motivation toward crowdsourcing feasibility in terms of quantity and quality of innovative solutions.
Franchising decision support system for formulating a center positioning strategy
Authors: Wu C.H. , Ho G.T.S. , Lam Cathy H. Y. , Ip W.H. 
Published: June 2015

Purpose– The purpose of this paper is to propose a franchising decision support system (FDSS) for future development planning by center positioning strategy formulation under a franchising business model.Design/methodology/approach– The system makes use of data collected from the franchising business and external environment analysis for decision making in center positioning problems. The fuzzy logic approach is integrated into the system for analyzing the geographical market dynamics including profitability and competitiveness in the district concerned. To demonstrate the application of the proposed FDSS, a case study is conducted in a Hong Kong-based franchising private education center, i.e. Dr I-Kids Education Center.Findings– The tailor made FDSS helps to facilitate the business operations of the franchising education center and develops a district positioning model for the centers located in the 18 districts of Hong Kong. The findings provide a solid foundation for marketing strategy and expansion direction formulation.Originality/value– Due to the globalization of business, managing a growing franchising business model becomes challenging to the franchisor. In order to fully leverage the merits of the franchising system, an intelligent decision support model, focusing on making strategic development plans, is needed so as to expand the scale of business efficiently.
An exploratory analysis of the relations between the rate of physiological habituation, the acquired capability for suicide, and acute risk factors for suicide
Authors: Smith Phillip N , Wolford-Clevenger Caitlin , Selwyn Candice N , Poindexter Erin , Lechner William , Grant DeMond M. , Cukrowicz Kelly C 
Published: June 2015

Purpose
– The interpersonal theory of suicide proposes that an individual must acquire the capability for suicide to carry out a near-lethal or lethal suicide attempt. This capability develops via habituation in response to painful and provocative life events. Some individuals might be more vulnerable to developing the capability for suicide because they habituate more quickly to stimuli. The purpose of this paper is to examine the relations between the rate of physiological habituation and acquired capability, proxies for acquired capability, and acute risk factors for suicide.

Design/methodology/approach
– Depressed, suicidal individuals completed self-report assessments and a startle reflex task assessing the rate or speed of physiological habituation in response to repeated bursts of white noise.

Findings
– Slower habituation was associated with hopelessness and negative stressors. The rate of habituation was not associated with acquired capability.

Originality/value
– The current study informs the understanding of how physiological habituation is related to suicide risk factors.
Murder-suicide: bridging the gap between mass murder, amok, and suicide
Authors: Hagan Christopher Ryan , Podlogar Matthew C , Joiner Thomas E 
Published: June 2015

Purpose– The purpose of this paper is to review the existing literature on mass murder and amok, and the relationship of these phenomena to murder-suicide as well as to determine future research directions.Design/methodology/approach– Research literature on mass murder, amok, and murder-suicide was reviewed in the context of recent developments in the understanding of suicide, aggressive behavior, and psychiatric diagnostics.Findings– Amok, typically viewed as a culture-bound disorder, occurs throughout the world and is best characterized as mass murder, similar to school shootings. Additionally, the phenomenon of mass murder may be best understood as a form of murder-suicide, related to the phenomenon of suicide-by-cop.Originality/value– This paper provides a review of the literature on murder-suicide, mass murder, and amok spanning over 110 years in the context of modern psychological research, new insights into the possible motivations of those who “run amok” and commit mass murder and provides future research directions for this important phenomenon.
Clinical supervision in prison settings: three strategies for approaching suicide risk
Authors: Magaletta Philip R , McLearen Alix M 
Published: June 2015

Purpose
– Delivering suicide risk services (SRS; i.e., assessment and intervention) is an important and demanding aspect of psychological practice in prison settings. Yet the authors know from the training literature that supervised opportunities to build skills in this domain are hard to obtain. The unpredictable nature of these crisis events and the seriousness of their consequences make it difficult for psychologists-in-training to gain experience managing them. An effective method for building the foundational base of such skill is through clinical activities during internship. The purpose of this paper is to introduce the topic from the perspective of doctoral psychology internship training in prisons. Conceptualized within a developmental training perspective, three specific supervisory actions that facilitate the practice of SRS for interns are detailed: locating opportunities to monitor the practice of developmentally appropriate SRS skills; utilizing an assessment tool to shape documentation and provide structured feedback on the quality of SRS work; and developing group-based role plays to practice the management skill of verbal interdisciplinary communication.

Design/methodology/approach
– Conceptualized within a developmental training perspective, three specific supervisory actions that facilitate the practice of SRS for interns are detailed.

Findings
– Findings include three actions: locating opportunities to monitor the practice of developmentally appropriate SRS skills; utilizing an assessment tool to shape documentation and provide structured feedback on the quality of SRS work; and developing group-based role plays to practice the management skill of verbal interdisciplinary communication.

Practical implications
– The authors have proposed three clinical supervision activities that can be used to facilitate the SRS learning experience. The strategies proposed are flexible enough to address variability within an individual intern or across a group of interns. While the authors apply the activities to interns, the authors believe it can also be used with early career psychologists as they transition to licensure and/or clinical independence within this practice setting. Ongoing consideration of how supervision is used to transmit the essential skills in this setting is paramount, and the authors hope this paper has provided sufficient justification for beginning the dialogue in this area.

Originality/value
– This work has never before been published.
Treating suicidal risk in a post-healthcare reform era
Authors: Jobes David A , Bowers Maureen Elizabeth 
Published: June 2015

Purpose– The purpose of this paper is to fully consider the potential changes in clinical suicide prevention that may evolve after the passing of the Patient Protection and Affordable Care Act (ACA). The authors argue that it is wise to anticipate demand for suicide-specific evidence-based treatments (EBTs) moving forward. The authors outline current best practices in clinical suicide prevention, and describe the Collaborative Assessment and Management of Suicidality (CAMS) as an example of how a suicide-focussed EBT can adapt to some predicted changes.Design/methodology/approach– This conceptual paper first presents an overview of the main effects of ACA within the behavioral health care (BHC) system. Next, the authors review contemporary approaches to the treatment of suicidal patients, as well as current treatment limitations. The authors present CAMS as a model of a suicide-focussed EBT that holds promise for use in the post-ACA era. To close, the authors discuss anticipated changes in suicide treatment and illustrate that CAMS is adaptable to these changes.Findings– ACA mandates several changes: implementation of EBTs, better preventative care, integrated treatment models, and improved healthcare administration. A central effect of ACA in BHC is the increased use of EBTs. Therefore effective EBTs for suicide prevention are described.Originality/value– Anticipating how ACA will affect clinical suicide prevention is necessary, as it is historically a very challenging area of treatment within BHC and a significant public health concern. This paper highlights the importance of the use suicide-specific EBTs.
“We(b)care”
Authors: Dens Nathalie , De Pelsmacker Patrick , Purnawirawan Nathalia 
Published: June 2015

Purpose– Consumers often discuss brands and companies online, but no research details how service providers’ responses to online reviews influence other readers’ perceptions of the reviews and responses. Based on justice theory and the accountability principle, both integrated in equity theory, the purpose of this paper is to examine how service providers should react to different degrees of negative reviews to enhance readers’ attitudes, patronage intentions, and intentions to spread positive word of mouth.Design/methodology/approach– A 3 (review set balance: positive, neutral, negative) × 6 (response strategy) full-factorial between-subjects experiment included 973 respondents.Findings– More negative balance demands more effort from the service provider to create positive attitudes and encourage behavioural intentions. If a minority of reviewers are dissatisfied, no response is necessary; if the review set is neutral, the service provider should apologize and promise to resolve the problem; if a majority of reviewers are dissatisfied, the most effective response includes both an apology, promise and compensation. These effects are mediated by readers’ perceived trust in the response. Word of mouth also requires more effort than favourable attitudes or patronage intentions.Research limitations/implications– This research reflects the authors’ choices with regard to review set balance and managerial responses, which ensure internal validity but may limit external validity.Originality/value– This study applies offline service recovery strategies to an online review context. It also explicitly incorporates the bystander (potential customer) perspective.