bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triboelectric Nanogenerators with Machine Learning for Internet of Things
Authors: Yang Jiayi , Hong Keke , Hao Yijun , Zhu Xiaopeng , Qin Yong , Su Wei , Zhang Hongke , Zhang Chuguo , Wang Zhong Lin , Li Xiuhan 
Published: August 2024

AbstractThe development of the Internet of Things (IoT) indicates that humankind has entered a new intelligent era of the “Internet of Everything”. Thanks to the characteristics of low‐cost, diverse structure, and high energy conversion efficiency, the self‐powered sensing systems, which are based on the Triboelectric Nanogenerator (TENG), demonstrate great potential in the field of IoT. In order to solve the challenges of TENG in sensing signal processing, such as signal noise and nonlinear relations, Machine Learning (ML), which is an efficient and mature data processing tool, is widely applied for efficiently processing the large and complex output signal data generated by TENG intelligent sensing system. This review summarizes and analyzes the adaptation of different algorithms in TENG and their advantages and disadvantages at the beginning, which provides a reference for the selection of algorithms for TENG. More importantly, the application of TENG is introduced in multiple scenarios, including health monitoring, fault detection, and human‐computer interaction. Finally, the limitations and development trend of the integration of TENG and ML are proposed by classification to promote the future development of the intelligent IoT era.
A Pyrazinyl Wide‐Bandgap Polymer Donor Yields 19.35% Efficiency in Tandem Organic Solar Cells
Authors: Liang Huazhe , Ma Kangqiao , Ding Shuhui , Zhao Wenkai , Si Xiaodong , Cao Xiangjian , Yao Zhaoyang , Duan Tainan , Long Guankui , Li Chenxi , Wan Xiangjian , Chen Yongsheng 
Published: August 2024

AbstractIn series‐connected tandem organic solar cells (TOSCs), various light‐harvesting molecules with complementary absorptions are explored with the aim of collaboratively utilizing solar light to the maximum extent. In sharp contrast to the small molecular acceptors that possessing almost the successively tunable bandgaps, high‐performance wide‐bandgap (WBG) polymer donors in TOSCs are quite scarce, with only PM6 (optical bandgaps, Egopt = 1.80 eV) and D18 (Egopt = 1.98 eV) being widely used. Herein, to develop WBG polymer donors with large open‐circuit voltages (VOC) and high‐energy photon absorption, two pyrazinyl polymer donors, PPy1 and PPy2, are synthesized with branched 2‐butyloctyl and n‐dodecyl chains on polymeric backbones, respectively, demonstrating the downshifted highest occupied molecular orbital energy levels of ≈−5.60 eV and thus afford Egopt over 2.0 eV. Consequently, when blending with a WBG acceptor F‐ThCl, PPy2:F‐ThCl‐based devices exhibit a higher power conversion efficiency (PCE) of 14.50% and fill factor of 77.66%. In light of its large VOC of 1.07 V, TOSCs based on PPy2 are further fabricated and exhibit an impressive PCE of 19.35% by using a narrow bandgap blend of PM6:CH1007:F‐2F as a rear cell. This work demonstrates the great potential of pyrazine units in constructing WBG polymer donors for achieving record‐breaking TOSCs.
Solving the Etiology of Developmental and Epileptic Encephalopathy with Spike–Wave Activation in Sleep (D/EE‐SWAS)
Authors: Viswanathan Sindhu , Oliver Karen L. , Regan Brigid M. , Schneider Amy L. , Myers Candace T. , Mehaffey Michele G. , LaCroix Amy J. , Antony Jayne , Webster Richard , Cardamone Michael , Subramanian Gopinath M. , Chiu Annie T.G. , Roza Eugenia , Teleanu Raluca I. , Malone Stephen , Leventer Richard J. , Gill Deepak , Berkovic Samuel F. , Hildebrand Michael S. , Goad Beatrice S. , Howell Katherine B. , Symonds Joseph D. , Brunklaus Andreas , Sadleir Lynette G. , Zuberi Sameer M. , Mefford Heather C. , Scheffer Ingrid E. 
Published: August 2024

ObjectiveTo understand the etiological landscape and phenotypic differences between 2 developmental and epileptic encephalopathy (DEE) syndromes: DEE with spike–wave activation in sleep (DEE‐SWAS) and epileptic encephalopathy with spike–wave activation in sleep (EE‐SWAS).MethodsAll patients fulfilled International League Against Epilepsy (ILAE) DEE‐SWAS or EE‐SWAS criteria with a Core cohort (n = 91) drawn from our Epilepsy Genetics research program, together with 10 etiologically solved patients referred by collaborators in the Expanded cohort (n = 101). Detailed phenotyping and analysis of molecular genetic results were performed. We compared the phenotypic features of individuals with DEE‐SWAS and EE‐SWAS. Brain‐specific gene co‐expression analysis was performed for D/EE‐SWAS genes.ResultsWe identified the etiology in 42/91 (46%) patients in our Core cohort, including 29/44 (66%) with DEE‐SWAS and 13/47 (28%) with EE‐SWAS. A genetic etiology was identified in 31/91 (34%). D/EE‐SWAS genes were highly co‐expressed in brain, highlighting the importance of channelopathies and transcriptional regulators. Structural etiologies were found in 12/91 (13%) individuals. We identified 10 novel D/EE‐SWAS genes with a range of functions: ATP1A2, CACNA1A, FOXP1, GRIN1, KCNMA1, KCNQ3, PPFIA3, PUF60, SETD1B, and ZBTB18, and 2 novel copy number variants, 17p11.2 duplication and 5q22 deletion. Although developmental regression patterns were similar in both syndromes, DEE‐SWAS was associated with a longer duration of epilepsy and poorer intellectual outcome than EE‐SWAS.InterpretationDEE‐SWAS and EE‐SWAS have highly heterogeneous genetic and structural etiologies. Phenotypic analysis highlights valuable clinical differences between DEE‐SWAS and EE‐SWAS which inform clinical care and prognostic counseling. Our etiological findings pave the way for the development of precision therapies. ANN NEUROL 2024;96:932–943
Evaluation of Glymphatic System Development in Neonatal Brain via Diffusion Analysis along the Perivascular Space Index
Authors: Lin Shiwei , Guo Meifen , Liang Qunjun , Lin Xiaoshan , Chen Shengli , Li Ying , Chen Peiqi , Qiu Yingwei 
Published: August 2024

ObjectiveGlymphatic system is a recently discovered macroscopic waste clearance system associated with numerous neurological diseases. However, little is known about glymphatic system development in neonates. We sought to evaluate diffusion along the perivascular space (ALPS) index, a proxy for glymphatic system function, in neonates and investigate its potential associations with maturation, sex, and preterm birth.MethodsDiffusion magnetic resonance imaging (MRI) data in 418 neonates, including 92 preterm neonates (57 males) and 326 term neonates (175 males), from the Developing Human Connectome Project were used for evaluating ALPS index. Linear regression modeling was performed to assess group differences in the ALPS index according to preterm birth and sex. Pearson's and partial correlation analysis were performed to assess the association between the ALPS index and gestational age (GA) as well as postmenstrual age (PMA) at MRI. Moderation analysis was performed to assess the moderation effect of preterm birth on the relationship between the ALPS index and PMA.ResultsCompared to term neonates, preterm neonates exhibited lower ALPS indices (p < 0.001). The ALPS index positively correlated with PMA (p = 0.004) and GA (p < 0.001). Preterm birth (p = 0.013) had a significant moderation effect on the relationship between the ALPS index and PMA. Sex had no significant direct effect (p = 0.639) or moderation effect (p = 0.333) on ALPS index.InterpretationGlymphatic system development is a dynamic process in neonates, which can be moderated by preterm birth, the ALPS index could serve as a sensitive biomarker for monitoring this process. ANN NEUROL 2024;96:970–980
Comparison of antioxidant efficiencies in oil‐in‐water emulsion using extracellular vesicles from olive co‐products or liposomes as antioxidants carriers
Authors: Baréa Bruno , Barouh Nathalie , Fenaghra Amal , Colosetti Pascal , Lecomte Jérôme , Durand Erwann , Mey Anne , Laugerette Fabienne , Michalski Marie‐Caroline , Bourlieu‐Lacanal Claire , Villeneuve Pierre 
Published: August 2024

AbstractOlive extracellular vesicles and synthetic liposomes were evaluated as carriers of antioxidants to stabilize oil‐in‐water emulsions against oxidative degradation. For this, hydroxytyrosol, rosmarinic acid and their lipophilic counterparts, (hydroxytyrosyl dodecanoate esters or eicosyl rosmarinate esters) were loaded into these carrier vesicles and the antioxidant efficiencies of these formulations were compared with those of the corresponding antioxidants alone. Using the conjugated autoxidizable triene assay (CAT assay), our results shows that loaded synthetic liposome mimicking the lipid membrane composition of olive extracellular vesicle allowed to enhance the antioxidant effect of the loaded antioxidant especially with the two lipophilic hydroxytyrosol and rosmarinic acid esters. On the contrary, the loading of the studied antioxidant into the olive extracellular vesicles did not result in an improvement of the antioxidant activity. The antioxidant effects of loaded vesicles were also evaluated in rapeseed oil (1% w/w)‐in‐water emulsions that were stored at 40°C for 21 days and for which oxidative status was monitored by the quantification of primary and secondary oxidation compounds. In that case, the boosting effect of liposomal carriers was not confirmed. This could be due to a different type of emulsions compared to the one used with the CAT assay as different surfactants and oxidation inducers were employed. Additionally, the limited physical stability of the carrier could be involved as liposomes loaded with the most lipophilic antioxidants, namely hydroxytyrosyl dodecanoate and eicosyl rosmarinate were shown to be instable for period exceeding 10 days of storage.
Adsorption studies of organic azo dyes from their aqueous solutions by a pH sensitive sodium alginate‐cl‐poly (N‐hydroxyethyl acrylamide‐co‐methacrylic acid) @Au/ montmorillonite nanocomposite hydrogel
Authors: Samanta Santu Kumar , Adak Shubhadeep , Tripathy Tridib 
Published: August 2024

AbstractA pH responsive monometallic‐clay nanocomposite hydrogel, sodium alginate‐cl‐poly (N‐hydroxy ethyl acrylamide‐co‐methacrylic acid) @ Au/ montmorillonite clay (SANCHG@Au/MMT) is synthesized in situ using sodium alginate (SA) as a polysaccharide. Two other nano composite hydrogels namely sodium alginate‐cl‐poly (N‐hydroxy ethyl acrylamide‐co‐methacrylic acid) @ Au (SANCHG@Au) and sodium alginate‐cl‐poly (N‐hydroxy ethyl acrylamide‐co‐methacrylic acid) @ montmorillonite clay (SANCHG@MMT) are also prepared. All the synthesized nano composite hydrogels are characterized using various techniques. Water swelling of the three hydrogels along with their textile dye adsorption properties is evaluated in congo red (CR), benzopurpurin (BP) and tartrazine (TZ) from their aqueous solutions. Among the three hydrogels the % water swelling of SANCHG@Au/MMT is superior (396% at pH = 8) and also the adsorption capacity over the other two. The dye adsorption property of SANCHG@Au/MMT is found to be pH sensitive. Adsorption follows both the Langmuir adsorption isotherm with Qmax values 512.19 mg.g−1 for CR at pH = 4, 476.09 mg.g−1 at pH = 4 for BP and 454.79 mg.g−1 at pH = 6 for TZ respectively and Dubinin–Radushkevich isotherm model. The kinetic data fit with pseudo second order kinetic model. Thermodynamic parameters like negative and positive values suggest that the adsorption process is spontaneous and endothermic in nature.
Pupillary response during social emotion tasks in autism spectrum disorder
Authors: Lee Juei‐Po , Chang Yi‐Hsuan , Tseng Yi‐Li , Chou Tai‐Li , Chien Yi‐Ling 
Published: August 2024

AbstractAutistic individuals encounter challenges in recognizing emotional expressions of others. Pupillary response has been proposed as an indicator of arousal dysregulation or cognitive load. The pupillary response of autistic individuals during socio‐affective tasks remains unclear. This study investigated pupillary response in autistic adults when viewing emotional faces/eyes and recognizing emotions during the Reading the Mind in the Eyes Test (RMET) and watching interpersonal touch scenes in the social touch task. The study included 98 participants diagnosed with autism spectrum disorder and 37 typically developing controls (TD). Pupil size was measured using the Tobii X2‐30 Eye Tracker. The results showed that autistic adults had larger maximal pupil sizes, smaller minimal pupil sizes, and greater change rates of pupil size, particularly during the RMET Eyes task. Clinical correlations revealed that attention switching difficulty positively correlated with mean pupil size in TD participants, while social communication deficits positively correlated with mean pupil size in autistic participants. In conclusion, our findings suggest atypical pupillary responses in autistic adults during socio‐affective tasks, indicating heightened cognitive demand. Further investigation is necessary to understand the underlying mechanisms and their association with autistic traits.
Edge‐Enriched MoS2 as a High‐Performance Cathode for Aqueous Zn‐Ion Batteries
Authors: Niu Mengfan , Wan Falian , Xin Wenli , Zhang Lei , Xiao Xilin , Zhang Hui , Yan Zichao , Zhu Zhiqiang 
Published: August 2024

AbstractRechargeable aqueous zinc ion batteries (AZIBs) with the advantages in low cost, high safety, and environmental friendliness have broad application prospects in the field of energy storage. However, the slow diffusion kinetics of multivalent Zn2+ in materials make it hard to find a suitable cathode. Herein, HNO3 etched MoS2 with edge‐enriched feature is proved to be a promising cathode for high‐performance AZIBs. The highly exposed edges with superior electrochemical activity can not only offer more reactive sites for zinc storage but also facilitate electrolyte accessibility and shortens the ion transport pathway, thus accelerating reaction kinetics. As a result, the edge‐enriched MoS2 cathode exhibited higher specific capacity of 187 mAh g−1 at 0.1 A g−1 and outstanding cycling performance (89 % capacity retention after 700 cycles at 1 A g−1).
Association of county level poverty with mortality from primary liver cancers
Authors: Ledenko Matthew , Patel Tushar 
Published: August 2024

AbstractBackgroundThe highly variable occurrence of primary liver cancers across the United States emphasize the relevance of location‐based factors. Social determinants such as income, educational attainment, housing, and other factors may contribute to regional variations in outcomes. To evaluate their impact, this study identified and analyzed clusters of high mortality from primary liver cancers and the association of location‐based determinants with mortality across the contiguous United States.MethodsA geospatial analysis of age‐adjusted incidence and standardized mortality rates from primary liver cancers from 2000 to 2020 was performed. Local indicators of spatial association identified hot‐spots, clusters of counties with significantly higher mortality. Temporal analysis of locations with persistent poverty, defined as high (>20%) poverty for at least 30 years, was performed. Social determinants were analyzed individually or globally using composite measures such as the social vulnerability index or social deprivation index. Disparities in county level social determinants between hot‐spots and non‐hot‐spots were analyzed by univariate and multivariate logistic regression.ResultsThere are distinct clusters of liver cancer incidence and mortality, with hotspots in east Texas and Louisiana. The percentage of people living below the poverty line or Hispanics had a significantly higher odds ratio for being in the top quintile for mortality rates in comparison to other quintiles and were highly connected with mortality rates. Current and persistent poverty were both associated with an evolution from non‐hotspots to new hotspots of mortality. Hotspots were predominantly associated with locations with significant levels of socioeconomic vulnerability or deprivation.ConclusionsPoverty at a county level is associated with mortality from primary liver cancer and clusters of higher mortality. These findings emphasize the importance of addressing poverty and related socio‐economic determinants as modifiable factors in public health policies and interventions aimed at reducing mortality from primary liver cancers.
Anion exchanger1 (AE1/SLC4A1) function is impaired in red blood cells from prediabetic subjects: Potential benefits of finger lime (Citrus australasica, Faustrime cultivar) juice extract
Authors: Remigante Alessia , Spinelli Sara , Gambardella Lucrezia , Straface Elisabetta , Cafeo Giovanna , Russo Marina , Caruso Daniele , Dugo Paola , Dossena Silvia , Marino Angela , Morabito Rossana 
Published: August 2024

AbstractPrediabetes is a risk state that defines a high chance of developing diabetes and cardiovascular disease. Oxidative stress mediated by hyperglycemia‐induced production of reactive species could play a crucial role in this context. In the present study, we investigated whether the anion exchange capability mediated by AE1 (SLC4A1), which is sensitive to oxidative stress, was altered in human red blood cells (RBCs) obtained from prediabetic volunteers. In addition, we assessed the precise composition of bioactive compounds and the potential benefits of finger lime juice extract (Citrus australasica, Faustrime cultivar) in counteracting oxidative stress‐related functional alterations. Human RBCs from normal and prediabetic volunteers were incubated with 50 µg/mL juice extract for 2 h at 25°C. Juice extract restored alterations of the anion exchange capability mediated by AE1 and prevented the structural rearrangements of AE1 and α/β‐spectrin in prediabetic RBCs. AE1 functional and structural alterations were not associated with an increase in lipid peroxidation or protein oxidation at the level of the plasma membrane. An increased production of intracellular ROS, which provoked the oxidation of hemoglobin to methemoglobin, both reverted by juice extract, was instead observed. Importantly, juice extract also induced a reduction in glycated hemoglobin levels in prediabetic RBCs. Finally, juice extract blunted the overactivation of the endogenous antioxidant enzymes catalase and superoxide dismutase and prevented glutathione depletion in prediabetic RBCs. These findings contribute to clarifying cellular and molecular mechanisms related to oxidative stress and glycation events that may influence RBC and systemic homeostasis in prediabetes, identify AE1 as a sensitive biomarker of RBC structural and function alterations in prediabetes and propose finger lime juice extract as a natural antioxidant for the treatment and/or prevention of the complications associated with the prediabetic condition.
Structural Stability of Mixed‐Halide Perovskite Nanocrystals in Energy Storage: The Role of Iodine Expulsion
Authors: Kumar Arun , Suhail Atif , Sagar Shukla Prem , Bag Monojit 
Published: August 2024

AbstractIn the pursuit of efficient optoelectronics devices, hybrid lead halide perovskite quantum dots (PQDs) have emerged as highly promising semiconductor materials due to their intriguing properties. While these materials have been used in many applications, the fundamental understanding of their behavior remains relatively unexplored, especially for the mixed halide perovskite samples. To facilitate the advancement of PQD technologies for commercial applications, it is essential to gain insights into the role of ion migration. This study delves into the fundamental aspects of ion migration in halide perovskite nanocrystals. Porous electrodes for supercapacitor application were fabricated using CsPbBr3–xIx (x=0,1,2) nanocrystals prepared via the ligand‐assisted re‐precipitation (LARP) method. Three‐electrode electrochemical measurements and several other characterizations were conducted under dark conditions to evaluate device performance and elucidate the impact of mixed halides on device kinetics and stability. X‐ray photoelectron spectroscopy before and after the electrochemical measurement reveals intriguing findings. Notably, the analysis uncovered the phase segregation in the metal halide perovskite nanocrystals with particular emphasis on CsPbBr2I due to its distinctive mixed‐halide behavior. The specific capacitance increases with the increasing cycles. Interestingly, as the iodide content increases, there is no selective halide expulsion as the structure collapses rapidly.
A Century of Prolactin: Emerging Perspectives as a Metabolic Regulator
Authors: Wu Tianyu , Duan Yanjie , Jiang Jiaxuan , Gu Tianwei , Zhang Pengzi , Bi Yan 
Published: August 2024

ABSTRACTProlactin, a hormone that has been studied for almost a century, has evolved from a reproductive regulator to a key player in metabolic health. Initially identified for its lactogenic role, the impact of prolactin on glucose and lipid metabolism became evident in the 1970s, leading to a paradigm shift in our understanding. Deviations in prolactin levels, including hyperprolactinaemia and hypoprolactinaemia, have been associated with adverse effects on glucose and lipid metabolism. Mechanistically, prolactin regulates metabolic homoeostasis by maintaining islet abundance, regulating the hypothalamic energy regulatory centre, balancing adipose tissue expansion, and regulating hepatic metabolism. Given the widespread use of pharmaceutical agents that affect prolactin levels, it is important to examine prolactin‐related metabolic effects. Recently, a profound exploration of the intricate metabolic role of prolactin has been conducted, encompassing its rhythm‐dependent regulatory influence on metabolism and its correlation with cognitive impairment associated with metabolic diseases. In this review, we highlight the role of prolactin as a metabolic regulator, summarise its metabolic effects, and discuss topics related to the association between prolactin and metabolic comorbidities.
Don't ignore the middle: Distinct mnemonic functions of intermediate hippocampus
Authors: Whitley Kathryn , Briggs Sherri B. , Sharma Karan , Parent Marise B. 
Published: August 2024

AbstractThe dorsal region of the hippocampus (dHC) mediates many of the mnemonic functions traditionally associated with the hippocampus proper, such as spatial and episodic memory, whereas ventral hippocampus (vHC) has been extensively implicated in emotional memory and motivational processes. By contrast, the functions of the intermediate hippocampus (iHC) are far less understood. In this study, we aimed to investigate the mnemonic functions of iHC by reversibly inactivating iHC prior to testing memory in behavioral tasks dependent on the integrity of dHC, iHC, or vHC, namely, rapid place water maze, inhibitory avoidance, spontaneous alternation, and temporal ordering of odors. Given our previous findings showing that dHC and vHC are involved in mnemonic control of ingestive behavior, we also assessed the effects of iHC inactivation on sucrose intake. The results showed that pharmacological inhibition of iHC impairs rapid place water maze memory, which has been previously shown to be dependent on iHC but not dHC or vHC. iHC inactivation does not impact memory dependent on dHC (spontaneous alternation), vHC (temporal odor memory), or either dHC or vHC (inhibitory avoidance), and only modestly affects sucrose intake. These findings provide support for the involvement of iHC in mnemonic functions that are distinct from dHC and vHC and highlight the need to further advance our understanding of the functions of this hippocampal region that has been relatively understudied.