bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linearity Study of Color Measurement Methods in Digital Image Colorimetry
Authors: Saukova Y. N. 
Published: July 2024

Color metrology is steadily developing in the interests of fundamental and applied science, improving industrial production processes. The author considers the problem of ensuring metrological traceability of color measurements under natural conditions.Digital image colorimetry methods demonstrate good linearity and precision in relatively small application ranges in studies of same type and mainly non-luminous objects. For complex scenes with a wide range of brightnesses, nonlinear functional color rendering models are used that are focused on visual perception, peak brightness of the monitor and reference viewing conditions, which complicates the processing of measurement results and reduces a confidence interval.The described method of measuring the chromaticity coordinates of an object by its digital image is based on tensor calculus and consists of multiple registration of an object and sets of reference samples with different exposure times, building calibration dependencies forming a multidimensional colorimetric scale in color space and determining chromaticity coordinates as points of intersection of color tensors with the plane of the color locus. In order to ensure accuracy and reliability of the measurement results in the software and hardware environments, a validation study of the performance indicators of this method was carried out, one of which is linearity. An experiment based on comparing the developed method with the reference measurement method showed the effectiveness of the developed wide-range measurement method with good linearity (correlation coefficient R=0.97… 0.99, residual relative standard deviation s0≈1–2%) when adjusting from the subjective factor and display device.The experimental materials may be useful to metrologists solving problems of determining the metrological traceability of the color of digital images in media. The article will be of interest to a wide range of readers with professional interests related to the colorimetry of digital images.
Producing Gel With Various Ingredients: a Review
Authors: Siagian Marthin Rivai Hezekiel , Abraham Sayid Umar , Yuliestyan Avido 
Published: July 2024

<p><strong>Abstract.</strong> Unhealthy fat choices in diets are linked to obesity and other health problems. The food industry faces a challenge to develop low-fat products that maintain desirable textures and functionalities. Food gels, semi-solid materials formed by small molecules or large organic molecules that can hold liquids, offer a promising approach for replacing fat in various food applications like yogurt, ice cream, and cheese. This review discusses recent research on: Types of biopolymers used for fat substitution in gels, including proteins, polysaccharides, and their combinations. The importance of rheological studies in understanding the characteristics of these fat-substituted gels. How manipulating rheological parameters can influence the texture and properties of food products.</p><p><strong>Keywords:</strong> </p><p align="left">Gel, Rheology, Fat, Protein, Polysaccharide</p>
Cell chirality reversal through tilted balance betweenpolymerization of radial bers and clockwise-swirling of transverse arcs
Authors: Kwong Hoi Kwan , Lam Miu Ling , Wu Siying , Chung Cho Fan , Chu Lok Ting , Chow Hiu Lam , Hartanto Hogi , Liu Wengang , Chen Ting-Hsuan , Wu Jianpeng , Lim King Hoo , Chow Kwan Ting 
Published: July 2024

Abstract

Cell chirality is an intrinsic property shown as biased cell rotation or orientation. While the righthanded helix of actin is known essential, it is intriguing of how single form of molecular handedness can be manifested into diverse and even mirrored forms of cell chirality. Here, we found that cell nucleus rotates with clockwise (CW) bias with smaller projected area but reverses to anticlockwise (ACW) bias when cell spreading increases. Actin analysis suggests that polymerization of righthanded radial fibers accounts for the ACW bias, while the CW bias is driven by the retrograde flow of CW-swirling transverse arc, which originates from tethered myosin II that simultaneously connect radial fibers and transverse arc. Thus, by tilting the balance between these two classes of actin fibers via cell spreading area or the main factors of actin, i.e., myosin II, α-actinin-1, Tpm4, and mDia2, the single form of actin helix can be unfolded into cell chirality with opposite bias. This finding suggests a mechanistic insight of cell chirality reversal, providing new perspective in mechanobiology and tissue formation.
Formation of deep mantle heterogeneities through basal exsolution contaminated magma ocean
Authors: DENG JIE , Miyazaki Yoshinori , Du Zhixue 
Published: July 2024

Abstract

Earth’s mantle harbors two large low shear-wave velocity provinces (LLSVPs) with patches of ultra-low velocity zones (ULVZs) distributed in the bottom. These structures exhibit distinct seismic and geochemical signatures compared to the surrounding mantle. Yet, their origin remains enigmatic. One proposed explanation is the differentiation of an early basal magma ocean (BMO). However, the presence of an excessively thick layer of iron-rich ferropericlase in the crystallized BMO conflicts with seismic tomography. Here, we investigate the crystallization of a BMO continuously contaminated by oxide exsolutions from the core, termed BECMO, and find significant suppression of ferropericlase crystallization and consequently a mineralogical profile consistent with LLSVPs and ULVZs. In addition, diapirs of core exsolution entrained into the solid mantle may cause small-scale scattering. The BECMO inherits the light silicon isotope composition from the core and exhibits trace element enrichments, suggesting its potential role as a source material for ocean island basalts potentially sampling the lowermost LLSVPs, pointing to a unified mechanism for forming deep mantle heterogeneities.
Assessing Clustering Replicability in Sensorineural Hearing Loss: Insights from the UK's Largest Audiogram Cohort
Authors: Dimitrov Lilia , lilaonitkul watjana , Mehta Nishchay 
Published: July 2024

Abstract

Despite nearly 20% of the global population experiencing hearing loss, there remains limited insight into the underlying subtypes of its most prevalent cause, sensorineural hearing loss (SNHL). This understanding is crucial for effective therapeutic and preventative strategies. A recent study using a Gaussian Mixture Model (GMM) identified 10 distinct SNHL phenotypes in a large US cohort, highlighting the potential of unsupervised machine learning to provide a data-driven solution to this task. Rigorous validation of these models is essential; however, it is limited due to several factors, including the absence of ground truth labels for model evaluation, restricted data access, and the lack of a standardized reporting framework for comparing results across clustering studies. Here, we apply GMM to a UK database of 109,854 audiograms, revealing 9 phenotypes, partly overlapping prior findings. Notably, our study cohort is characterized by advanced age, a higher proportion of female participants, and more severe hearing impairments. We observed instability in the GMM model when subjected to variations in the original dataset. To enhance practices, we propose a Clustering Replicability Framework, ensuring robustness in unsupervised machine learning-driven health research for safe clinical translation. Words: 187
Feasibility of using a novel hand-training support robot for patients with acute stroke and severe hand paralysis: A retrospective study
Authors: Ochi Mitsuhiro , Hori Ryoko , Tokunaga Mizuki , Moriyama Yasuyuki , Hachisuka Akiko , Ito Hideaki , Matsushima Yasuyuki , Saeki Satoru 
Published: July 2024

Abstract

Background: Approximately 80% of patients with stroke develop upper limb dysfunction. Although the greatest recovery of hand function is seen in the acute phase, only 14% achieve complete recovery. Beginning upper extremity functional training and repetitive movements from the early stage of stroke onset is considered important; however, in the acute stage of stroke, during which getting out of the bedside and self-care training are prioritized, patients often use the unaffected upper extremity. The newly developed EsoGLOVE robot hand training module is expected to assist with bedside hand function training. In this retrospective study, we aimed to evaluate the feasibility of training using this novel hand training support robot and assess its effectiveness.
Methods: The pneumatic robot provided auxiliary movements, such as flexion and extension of the fingers and passive movements. Of 24 eligible patients with similar Brunnström hand recovery stage, 12 who received treatment with EsoGLOVE were assigned to the robot-assisted training group, and 12 who did not were assigned to the usual training group. Some durability issues were encountered, and improvements were made to the robot at the therapists’ requests to make it easier to use. The primary outcome was the Brunnström hand recovery stage. Baseline comparisons between men and women were performed using the chi-square test for categorical variables (ischemic or hemorrhagic stroke) and the Mann–Whitney test for continuous variables. Within-group comparisons were performed using the Wilcoxon test for the primary outcome. Owing to the non-normal distribution of the data, between-group comparisons were performed using the Mann–Whitney U test.
Results: No adverse events were associated with robot use (20–40 min a day, five times a week) in addition to conventional training during the early subacute phase. Compared with patients who underwent conventional training alone, hand and finger functions improved significantly (p=0.018) in those who used the robot after approximately 2 months.
Conclusions: The EsoGLOVE robot is safe to use and has high clinical practicality. Nevertheless, we plan to conduct a prospective comparative study to verify its effectiveness.
Enhancing the therapeutic effect of infliximab by inhibiting ferroptosis of M2 macrophages in experimental colitis
Authors: Feng Zelin , Ye Yulin , Liu Limin , Zhu Zhixin , Liu Yifei , Miao Junming , Wei Xinyue , Li Huizhen , Kang Guangbo , Huang He , Cao Xiaocang 
Published: July 2024

Abstract

Objective
Drug combination presents a promising approach to surpassing the current efficacy limitations of biological agents in treating inflammatory bowel disease (IBD). Currently, ferroptosis has emerged as a novel therapeutic target for IBD. Therefore, combining ferroptosis inhibitors with biologics may provide a new therapeutic strategy to break the therapeutic ceiling of IBD treatment. Thus, this study investigated whether ferroptosis inhibitors could enhance infliximab (IFX) efficacy on IBD.
Methods
Immunofluorescence was used to analyze M2 macrophages in human colon specimens pre- and post-IFX treatment. The effect of IFX on ferroptosis of M1 and M2 macrophages was assessed on RAW264.7 in vitro. Moreover, a DSS-induced colitis mouse model was employed to evaluate the impact of ferroptosis inhibitors on IFX efficacy in vivo.
Results
Although M2 macrophages were increased in patients who responded to IFX treatment, there was no concurrent increase in non-responders which suggested that the efficacy of IFX was closely related to M2 macrophage. Notably, IFX enhanced ferroptosis in M1 and M2 macrophages in vitro, while M2 macrophages were more sensitive to ferroptosis than M1 macrophages. Finally, the ferroptosis inhibitor deferoxamine enhanced IFX efficacy by significantly alleviating mucosa ferroptosis in experimental colitis mice and also had a protective effect on M2 macrophages undergoing IFX.
Conclusions
The current results suggested that ferroptosis inhibitors could enhance the therapeutic efficacy of IFX by rescuing M2 macrophages from ferroptosis, thereby offering a new strategy for overcoming the current therapeutic ceiling of IBD biologic therapy.
RBM10 regulates LncRNA SNHG17 alternative splicing to suppress colorectal cancer invasion mechanism research
Authors: An Linxia , Chen Peng , He Miao , Li huifeng , Zhou Yingshu , Geng Changhui , zhao hong wei 
Published: July 2024

Abstract

Objective: To explore the role of RBM10 in colorectal cancer (CRC) and the regulatory mechanism of CRC invasion through alternative splicing (AS) of long non-coding RNA (lncRNA) SNHG17 by RBM10.
Methods: Samples were collected from sixty cases of CRC and their corresponding adjacent normal tissues. Immunohistochemistry and Western blot were performed to analyze the expression of RBM10. A Transwell invasion assay was conducted to evaluate the effect of RBM10 on the invasion of HCT116 cells, and a Western blot was performed to detect the expression of EMT-related proteins. Moreover, CLIP-seq and RIP experiments were performed to explore the interaction between RBM10 and SNHG17.
Results: The expression of RBM10 was significantly decreased in CRC tissues and cells compared to the normal adjacent tissues. Overexpression of RBM10 inhibited CRC invasion, while knockdown of RBM10 had the opposite effect. RBM10 was found to interact with SNHG17 and regulate its splice isoform balance. Specifically, the splice variant SNHG17_2 regulated by RBM10 was upregulated in CRC and was positively correlated with CRC invasion.
Conclusion: RBM10 inhibits CRC invasion by regulating the alternative splicing of SNHG17, providing new research directions and potential targets for CRC treatment.
Optimizing the Application of Machine Learning Models in Predicting Landslide Susceptibility Using the Information Value Model in Junlian County of Sichuan Basin
Authors: Qian Lijun , Ou Lihua , Li Guoxin , Cheng Ying 
Published: July 2024

Abstract

Constructing accurate landslide susceptibility models is crucial for effective landslide prevention.This study explores methods to enhance the accuracy of landslide susceptibility models.This paper focuses on Junlian County, Sichuan, as the study area.Initially, a landslide inventory was created using field surveys and historical records.Eight environmental factors were identified via correlation analysis: elevation, slope, aspect, stratigraphic lithology, and distances from faults, roads, rivers, and areas of land use.Subsequently, we constructed an information value model.For training the IV-RF model, non-landslide points in areas of low susceptibility were randomly selected at various ratios (1:1, 1:2, 1:3, 1:4, 1:5).The optimal ratio was used to develop coupled models (IV-RF, IV-LR, IV-SVM, IV-BP), comparing their accuracy and discussing the impact of environmental factors on landslide susceptibility.Results indicate that: (1) the highest prediction accuracy was achieved with a non-landslide ratio of 1:1; (2) the IV-RF model achieved the highest AUC of 0.994; and (3) the most significant factors influencing landslide distribution were stratigraphic lithology and river proximity, followed by elevation and fault distance.
Contusion expansion, bifrontal contusions and low platelet count is associated with worse patient outcome following traumatic brain injury - a retrospective single-center study
Authors: Andersson Alice S. , Hossain Iftakher , Marklund Niklas 
Published: July 2024

Abstract

Background Cortical contusions are common in moderate-severe traumatic brain injury (TBI). Cortical contusions often expand, potentially causing neuro-worsening several hours to days post-trauma. While contusion expansion (CE) may affect outcome, potential clinical and radiological markers that can predict CE have been insufficiently explored. In the present single-center retrospective observational cohort study, we evaluated clinical outcome by the Glasgow Outcome Scale extended (GOSE) scale and evaluated risk factor for CE.Method Adult TBI patients > 18 years of age, and of all injury severities, were included. Main variables of interest were low platelet count, defined as < 150x109/L, presence of bifrontal contusions and CE, defined as absolute contusion volume increase in cm³. Factors associated with CE and clinical outcome according to GOSE were analyzed.Results Between 2012–2022, 271 patients were included. Contusion size on admission correlated positively with CE, as did the Marshall and Rotterdam radiological classification scores. Bifrontal contusions were significantly larger at admission, experienced larger CE, and had a worse outcome than contusions in other locations. Patients with a platelet count < 150x109/L experienced a greater volume CE and had a worse outcome when compared to patients with a normal platelet count. In a multivariate analysis, CE remained significantly associated with a poor outcome six months post- injury.Conclusion Contusion volume at admission, and Marshall- and Rotterdam scores, positively correlated to CE. Bifrontal contusions and a platelet count < 150x109/L were associated with CE, and a poor clinical outcome. Large CE volumes were associated with a worse clinical outcome, and CE was per se associated with outcome in a multivariate analysis. Management of these risk factors for CE in the acute post-injury setting may be needed to attenuate contusion expansion and to improve clinical outcome in TBI patients suffering from cortical contusion injuries.
Lactobacillus paracasei-derived extracellular vesicles reverse molecular and behavioral deficits in mouse models of autism spectrum disorder
Authors: Han Pyung-Lim , Park Jin-Young , Lee Eun-Hwa , Paeng Jae-Won , Paeng Jin-Chul , Kim Yoon-Keun 
Published: July 2024

Abstract

Autism spectrum disorder (ASD) is a heterogenous group of neurodevelopmental disorders characterized by social communication deficits and repetitive behaviors. While our current understanding the mechanisms underlying ASD is growing, effective treatment options are still underdevelopment. Extracellular vesicles derived from the probiotic Lactobacillus paracasei (LpEV) exhibit neuroprotective effects in vitro and in vivo models. This study investigates whether LpEV can improve core symptoms in genetic ASD models that represent accumulated developmental deficits. Mice lacking dopamine receptor-2 (Drd2 KO mice) exhibit social behavior deficits and excessive grooming. LpEV treatment in Drd2 KO mice significantly improves these autistic-like behaviors, suggesting LpEV's ability to potentially mitigate the persistent dysregulated signaling pathways in these mice. RNA sequencing followed by gene ontology enrichment analysis of LpEV-treated Drd2 KO mice reveals distinct groups of genes with expression reversed by LpEV. Notably, a high proportion of these genes overlap significantly with known ASD genes in the SFARI database, strengthening the potential of LpEV to target relevant pathways in ASD. Further investigation identifies Oxytocin and Oxytocin receptor (Oxtr) as potential therapeutic targets. LpEV treatment significantly improves autistic-like behaviors in mice with reduced Oxtr function (Oxtr heterozygous mice). LpEV treatment also improves autistic-like behaviors in mice lacking adenylyl cyclase-5, suggesting its potential to target ASD through broader mechanisms beyond a single pathway. These results highlight the therapeutic potential of LpEV in reversing the accumulated dysregulated signaling pathways critical for ASD core symptoms and improving autistic-like behaviors.
Performance Measurement Systems in Primary Health Care: A Systematic Literature Review
Authors: Santos Carlos Jefferson de Melo , Barbosa Ava Santana , Sant'Anna Ângelo Marcio Oliveira 
Published: July 2024

Abstract

Background: Performance measurements are increasingly used in health services, however, there is a lack of these types of applications in the literature, especially for performance measurement systems in primary health care. The concepts of a performance measurement system (SMD) constitute a limitation in the literature for what has been implemented to date in primary health care services. This article constructs a systematic review of peer-reviewed literature to demonstrate current constructs used in performance measurement systems in different areas of primary care.
Methods: The document uses the PRISMA approach, considered the gold standard for synthesis of evidence and studies reported as scientific or dark literature. To evaluate the quality of the selected studies, the four categories of The Rosalind Franklin Qualitative Research Appraisal Instrument - RF-QRA were used.
Results: Of the 167 articles extracted, fourteen studies were selected and showed that there is a difficulty in evaluating the post-implementation of performance measurement systems directly in primary care units, which brings a study limitation and the lack of evidence of monitoring indicators throughout over time.
Conclusions: The development of the systematic review process that emphasizes heterogeneity, diversification, reliability and originality reflected a diagnosis based on the last five years of the best MDS models implemented around the world. This may reflect the implementation of public policies focusing on high-performance primary health care.
Finite Element Analysis of PFNA and PFNA Combined with Locking Plate in Treatment of Femoral Intertrochanteric Fracture with Lateral Wall Fracture
Authors: Zhou Long , Wang Liang , Xu Rui , Bao Yidong , He Shuangjian 
Published: July 2024

Abstract

Purpose: The biomechanical characteristics of Proximal Femoral Nail Antirotation (PFNA) and PFNA combined with Proximal Humerus Locking Plate (PHLP) in treatment of femoral intertrochanteric fracture with lateral wall fracture were compared by finite element analysis, and the biomechanical strength, stress and displacement distribution of the two internal fixation methods were compared.
Methods: A healthy middle-aged female patient was selected. According to the femur CT scan data, the three-dimensional finite element models of the femur, PFNA, and PHLP were established .The simulated AO classification was 31-A3.3 femoral intertrochanteric fracture, and the two internal fixation assembly models of PFNA and PNFA+PHLP were established. The von mises stress distribution and displacement distribution nephograms of the two internal fixation models were observed when the same load was applied on the two models under the dynamic and static status.
Result: Compared with PFNA fixation, PFNA+PHLP fixation reduced the maximum von mises stress by about 40%, while the maximum displacement changed little. The stress at the fracture end and the main nail position decreased, with a noticeablereduction of about 40% at the main nail. The Von Mises stress of the femoral head, femoral neck, medial, wall and spiral blade changed little. The total displacement of the femoral head, femoral neck, lateral wall, and spiral blade of PFNA+PHLP fixation decreased insignificant.
Conclusion: PFNA + PHLP internal fixation in the treatment of femoral intertrochanteric fracture with lateral wall fracture has higher fixation strength and more reasonable stress distribution than PFNA internal fixation.