bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prenatal diagnosis of SLC25A24 Fontaine progeroid syndrome: description of the fetal phenotype, genotype and detection of parental mosaicism
Authors: Pannier Emmanuelle , Sekri Abel , Roux Nathalie , Vasiljevic Alexandre , El Khattabi Laïla , Chatron Nicolas , Grotto Sarah , Menzella Delphine , Grangé Gilles , Thébault Florent , Massardier Jérôme , Fourrage Cécile , Lohmann Laurence , Tsatsaris Vassilis , Putoux Audrey , Boutaud Lucile , Attié‐Bitach Tania 
Published: July 2024

AbstractBackgroundFontaine progeroid syndrome (FPS, OMIM 612289) is a recently identified genetic disorder stemming from pathogenic variants in the SLC25A24 gene, encoding a mitochondrial carrier protein. It encompasses Gorlin–Chaudry–Moss syndrome and Fontaine–Farriaux syndrome, primarily manifesting as craniosynostosis with brachycephaly, distinctive dysmorphic facial features, hypertrichosis, severe prenatal and postnatal growth restriction, limb shortening, and early aging with characteristic skin changes, phalangeal anomalies, and genital malformations.CasesAll known occurrences of FPS have been postnatally observed until now. Here, we present the first two prenatal cases identified during the second trimester of pregnancy. While affirming the presence of most postnatal abnormalities in prenatal cases, we note the absence of a progeroid appearance in young fetuses. Notably, our reports introduce new phenotypic features like encephalocele and nephromegaly, which were previously unseen postnatally. Moreover, paternal SLC25A24 mosaicism was detected in one case.ConclusionsWe present the initial two fetal instances of FPS, complemented by thorough phenotypic and genetic assessments. Our findings expand the phenotypical spectrum of FPS, unveiling new fetal phenotypic characteristics. Furthermore, one case underscores a potential novel inheritance pattern in this disorder. Lastly, our observations emphasize the efficacy of exome/genome sequencing in both prenatal and postmortem diagnosis of rare polymalformative syndromes with a normal karyotype and array‐based comparative genomic hybridization (CGH).
Exploring the interplay between intellectual property models and sustainability transitions: A multi‐level analysis
Authors: Jain Akriti , Gurtoo Anjula , Eppinger Elizabeth , Vimalnath Pratheeba , Tietze Frank 
Published: July 2024

AbstractResearch on international technology transfer and partnership agreements provides a comprehensive understanding of country‐level impacts of intellectual property (IP) rights on sustainability transitions. However, firm‐level studies on how firms use and share their IP to support sustainability practices remains limited. The paper disentangles the relationship between firm‐level IP models and sustainability practices drawing from a cross‐case analysis of 28 firms offering sustainable innovations across four sectors. Analysis of firms' year‐wise data collected from 854 documents (typically 1996–2021) and 58 in‐depth interviews exploring linkage between IP models and sustainability practices of firms engaged in sustainable innovation provide six key findings: (a) emphasis on safeguarding registered and unregistered IP assets among firms with sustainable innovations; (b) widespread adoption of selectively open inbound IP models coupled with diverse IP sharing mechanisms; (c) a preference for collaborative (joint) IP ownership among internally driven firms, contrasting with a tendency for exclusive in‐licensing among those reacting to external pressures; (d) a divergence in outbound IP models, with internally motivated firms favouring selectively open approaches and externally driven firms favouring closed IP models; (e) the adoption of fully open outbound IP models democratize sustainable innovation diffusion; and (f) leveraging broadly open outbound IP models alongside closed or selectively open models balances widespread use with access control and achieves significant social sustainability. A framework is hence developed to guide technology‐sharing policies and procedures. Therefore, the paper creates a platform for prescribing sustainable IP incentives for encouraging firms to share IP for wider diffusion of sustainable innovations.
Energy band engineering of graphitic carbon nitride for photocatalytic hydrogen peroxide production
Authors: Gao Tengyang , Zhao Degui , Yuan Saisai , Zheng Ming , Pu Xianjuan , Tang Liang , Lei Zhendong 
Published: July 2024

AbstractHydrogen peroxide (H2O2) is one of the 100 most important chemicals in the world with high energy density and environmental friendliness. Compared with anthraquinone oxidation, direct synthesis of H2O2 with hydrogen (H2) and oxygen (O2), and electrochemical methods, photocatalysis has the characteristics of low energy consumption, easy operation and less pollution, and broad application prospects in H2O2 generation. Various photocatalysts, such as titanium dioxide (TiO2), graphitic carbon nitride (g‐C3N4), metal‐organic materials, and nonmetallic materials, have been studied for H2O2 production. Among them, g‐C3N4 materials, which are simple to synthesize and functionalize, have attracted wide attention. The electronic band structure of g‐C3N4 shows a bandgap of 2.77 eV, a valence band maximum of 1.44 V, and a conduction band minimum of −1.33 V, which theoretically meets the requirements for hydrogen peroxide production. In comparison to semiconductor materials like TiO2 (3.2 eV), this material has a smaller bandgap, which results in a more efficient response to visible light. However, the photocatalytic activity of g‐C3N4 and the yield of H2O2 were severely inhibited by the electron‐hole pair with high recombination rate, low utilization rate of visible light, and poor selectivity of products. Although previous reviews also presented various strategies to improve photocatalytic H2O2 production, they did not systematically elaborate the inherent relationship between the control strategies and their energy band structure. From this point of view, this article focuses on energy band engineering and reviews the latest research progress of g‐C3N4 photocatalytic H2O2 production. On this basis, a strategy to improve the H2O2 production by g‐C3N4 photocatalysis is proposed through morphology control, crystallinity and defect, and doping, combined with other materials and other strategies. Finally, the challenges and prospects of industrialization of g‐C3N4 photocatalytic H2O2 production are discussed and envisioned.
Enantioselective Hydroaminations Catalyzed by Yttrium(III)‐Bis(sulfoximine) Complexes
Authors: Fuchs Julia , Immel Stefan , Bauer Dominik , Reggelin Michael 
Published: July 2024

AbstractBis(sulfoximine) yttrium complexes as catalysts for enantioselective intramolecular hydroaminations were prepared for the first time and characterized by a multinuclear NMR study including the nuclei 1H, 13C, 15N and 89Y. The stoichiometries of the complexes were confirmed by a Job plot. In addition to the experimental results, the 89Y NMR shifts and the complex structures were elucidated by DFT calculations.
From circular to square‐based section spouted beds: Scale‐up and design overview of a multistage thermal unit
Authors: Rovero Giorgio , Curti Massimo , Moliner Cristina , Arato Elisabetta 
Published: July 2024

AbstractThis work summarizes the results of several research projects to demonstrate the possibility of scaling‐up spouted beds by assembling a number of square‐based jet units. Cylindrical vessels with a bottom cone and parallelepiped ones with a frustum base do not differ to a large extent in terms of hydrodynamic features. The existing correlations can be used to predict these square‐based spouted beds. Spouted beds can be very reasonably described as well‐mixed reactors. By assembling several units, it is possible to approach a plug flow state for solids residence time distribution (RTD) in continuous processes. Spouting stability is fully reached when the modules do not interfere each other: this goal is obtained by positioning the downstream units at a certain lower level and having the solids move by overflow; placing internal vertical baffles between contiguous units is the solution. Two hydrodynamical models are proposed to describe single and multiple spouted beds; their predictions help in choosing the best geometrical configuration for the assemblage. A possible application of a multiple spouted bed reactor was envisaged for gasifying pelletized textile residues to generate syngas which can be directly used in situ as a co‐fuel. Two units were built: a single 0.2 m side square‐based spouted bed furnace and the consequent dual stage scale‐up apparatus suitable for an auto thermal process. In the bottom stage, four units work independently to run combustion/gasification of low‐quality solid residues, while the upper stage had a cascade of four modules to run pyrolysis/gasification of selected biomass and obtain valuable secondary products.
Enhancing healthcare security: Time‐based authentication for privacy‐preserving IoMT sensor monitoring framework leveraging blockchain technology
Authors: Sharma Aashima , Kaur Sanmeet , Singh Maninder 
Published: July 2024

SummaryThe rapid progression of the Internet of Things and its increasing use in healthcare has generated considerable concerns over the safeguarding and privacy of vital medical data. In response to these issues, blockchain has surfaced as a possible remedy, offering transparent, immutable, and decentralized storage. Nevertheless, conventional blockchain‐based systems still encounter constraints in maintaining anonymity, confidentiality, and privacy. Hence, this article suggests a framework based on a secure consortium blockchain that prioritizes data privacy and employs time‐based authentication to streamline patient data monitoring. First, we employ time‐based authentication to verify the identities of authorized users. This process utilizes the NIK‐512 hashing algorithm in conjunction with passwords and registered timestamps, which strengthens the confidentiality of data. Patient information undergoes encryption before transmission within the network. Further, our framework introduces a sensor registration service that the trusted node employs to assign a distinct identity to each sensor connected to a patient. The implementation of data processing and filtering techniques at the edge layer serves the purpose of mitigating disturbances that may occur during the collection of sensor‐based data. Finally, a comprehensive evaluation of performance and security has been carried out with various metrics. The findings indicate that the proposed solution effectively enhances the management of Internet of Medical Things data by providing improved privacy and security.
Preparation of WO3‐Mica Hybrid Coatings with Electrochromic Properties and Pearl Luster
Authors: Svensson Fredric G. , Uchiyama Hiroaki 
Published: July 2024

AbstractTungsten oxide‐mica composites were prepared by adding different amounts of commercial mica (alumina silicate) in order to provide high luster to electrochromic coatings. The mechanical stability was sustained for up to 50 weight % mica for application in aqueous medium. The electrochemical properties, coloration, and luster were investigated. The luster of the composites increased roughly linearly with increased mica content and was retained after coloration. The addition of 10 weight % mica was found to be optimal with respect to the compromise between electrochromic coloration and pearlescent luster. This is, to the best of our knowledge, the first report on the preparation and characterization of WO3‐mica inorganic composites with high luster in both bleached and colored states.
Characterization and Application of Cyrene as a Biomass‐Based Solvent for Homogeneous Heck‐Coupling Reaction
Authors: Medgyesi Zoltán , Mika László T. 
Published: July 2024

AbstractCyrene, a renewable, non‐toxic substance having negligible vapor pressure, even at high temperatures, was proposed as a reaction medium for homogeneous Pd‐catalyzed Heck‐coupling reactions. It was first characterized by its temperature‐dependent physicochemical properties, i. e., vapor pressure, density, surface tension, heat capacity, and viscosity, the key parameters of its reaction and process chemistry. Its refractive indices in the function of temperature were also determined. Hereafter, the effect of reaction parameters (Pd source, nature of the base, the water content of the reaction mixture, leaving group (−I, −Br, −Cl, and −OTf of aromatic substrates) on Pd‐catalyzed Heck‐coupling reaction was investigated using iodobenzene and styrene as model substrates. Subsequently, 4‐substituted iodobenzene and styrene derivatives were applied to investigate the effect of electronic parameters on the reaction efficiency and functional group tolerance. To demonstrate the applicability of the system, thirteen stilbene derivatives were isolated with good to high yields and purity (>95 %) using 0.2 mol % of Pd, 1.5 eq. of Et3N as a base, in 1 mL of Cyrene for 2 h at 100 °C.
Prescribe for patients with opioid use disorder — with confidence
Authors: Knopf Alison 
Published: July 2024

A new message from the Food and Drug Administration (FDA) encourages primary care providers to prescribe medication — primarily, buprenorphine — for opioid use disorder (OUD) “with confidence.” In the missive, subtitled “Patients with opioid use disorder need you,” the FDA noted that more than 6 million people age 12 or older have an OUD. Below is the FDA statement.
Advances and Challenges in Interfacial Binding Forces for Electrocatalysts
Authors: Yan Xing , An Fengxia , Li Yuxiang , Xie Junliang , Du Heng , Yu Zhonghao , Jiang Fang , Chen Huan 
Published: July 2024

AbstractAs a practical chemical energy conversion technology, electrocatalysis could be used in fields of energy conversion and environmental protection. In recent years, significant research efforts have been devoted to the design and development of high‐performance electrocatalysts because the rational design of catalysts is crucial for enhancing electrocatalytic performance. Creating electrocatalysts by forming interactions between different components at the interface is an important means of controlling and improving performance. Therefore, several common interfacial binding forces used for synthesizing electrocatalysts was systematically summarized in this review for the first time. The discussion revolves around the crucial roles these binding forces play in various electrocatalytic reaction processes. Various characterization techniques capable of proving the existence of these interfacial binding forces was also involved in the review. Finally, some prospects and challenges for designing and researching materials through the utilization of interfacial binding forces were presented.
Harnessing Ultrasound‐Derived Hydroxyl Radicals for the Selective Oxidation of Aldehyde Functions
Authors: Fischer Ari F. , Bahry Teseer , Xie Zhangyue , Qian Kaicheng , Li Renhong , Kwan James , Jerome François , Valange Sabine , Liu Wen , Amaniampong Prince N. , Choksi Tej S. 
Published: July 2024

AbstractUltrasonic irradiation holds potential for the selective oxidation of non‐volatile organic substrates in the aqueous phase by harnessing hydroxyl radicals as chemical initiators. Here, a mechanistic description of hydroxyl radical‐initiated glyoxal oxidation is constructed by gleaning insights from photolysis and radiation chemistry to explain the yields and kinetic trends for oxidation products. The mechanistic description and kinetic measurements reported herein reveal that increasing the formation rate of hydroxyl radicals by changing the ultrasound frequency increases both the rates of glyoxal consumption and the selectivity towards C2 acid products over those from C−C cleavage. Glyoxal consumption also occurs more rapidly and with greater selectivity towards C2 acids under acidic conditions, which favor the protonation of carboxylate intermediates into their less reactive acidic forms. Leveraging such pH and frequency effects is crucial to mitigating product degradation by secondary reactions with hydroxyl radicals and oxidation products (specifically hydrogen peroxide and superoxide). These findings demonstrate the potential of ultrasound as a driver for the selective oxidation of aldehyde functions to carboxylic acids, offering a sustainable route for valorizing biomass‐derived platform molecules.
Graphitic Carbon Nitride Structures on Carbon Cloth Containing Ultra‐ and Nano‐Dispersed NiO for Photoactivated Oxygen Evolution
Authors: Scattolin Enrico , Benedet Mattia , Rizzi Gian Andrea , Gasparotto Alberto , Lebedev Oleg I. , Barreca Davide , Maccato Chiara 
Published: July 2024

AbstractThe development of low‐cost and high‐efficiency oxygen evolution reaction (OER) photoelectrocatalysts is a key requirement for H2 generation via solar‐assisted water splitting. In this study, we report on an amenable fabrication route to carbon cloth‐supported graphitic carbon nitride (gCN) nanoarchitectures, featuring a modular dispersion of NiO as co‐catalyst. The synergistic interaction between gCN and NiO, along with the tailoring of their size and spatial distribution, yield very attractive OER performances and durability in freshwater splitting, of great significance for practical end‐uses. The potential of gCN electrocatalysts containing ultra‐dispersed, i. e. “quasi‐atomic” NiO, exhibiting a higher activity than the ones containing nickel oxide nanoaggregates, is further highlighted by their activity even in real seawater. This work suggests that efficient OER catalysts can be designed through the construction of optimized interfaces between transition metal oxides and carbon nitride, yielding inexpensive and promising noble metal‐free systems for real‐world applications.
Following the Structural Changes of Iron Oxides during Reduction under Transient Conditions
Authors: Braun Lukas , Spielmann Jonas , Doronkin Dmitry E. , Kuhn Carola , Maliugin Aleksandr , Sharapa Dmitry I. , Huck Isabel , Bao Jianing , Tischer Steffen , Studt Felix , Deutschmann Olaf , Kramm Ulrike I. , Grunwaldt Jan‐Dierk 
Published: July 2024

AbstractIron is considered as attractive energy carrier in a carbon‐free, circular energy economy. The reduction of iron oxide is crucial for its application as a metal fuel as it determines the efficiency of the cycle. Temperature programmed reduction of α‐Fe2O3 was monitored by complementary X‐ray absorption spectroscopy (XAS) and diffraction (XRD) to obtain the phase composition with high time resolution. Synchrotron Mössbauer spectroscopy (SMS) was additionally employed due to its high sensitivity to the different iron species. Theoretical calculations of surface and bulk adsorption processes were performed to establish the potential reaction pathways and the corresponding energy barriers. A kinetic particle model was then developed to bridge the experimental data and theoretical calculations, which reproduced the reduction onset and behavior. The reduction process was found to be strongly dependent on the heating rate in terms of the reduction window and the observed intermediate species. We propose that a core‐shell mechanism determines the reaction by forming an iron layer which subsequently hinders diffusion of water out of the porous particles leading to some unreduced FeO at high temperature. This study demonstrates the need for complementary methods for describing complex heterogeneous systems and overcoming the chemical sensitivity limitations of any single method.
Pavlov dog feature memory circuit based on memristor under different emotional conditions
Authors: Wang Zexin , Yang Yan , Xin Yuan , Wang Dongqing 
Published: July 2024

AbstractThe memristor‐based Pavlov circuits have been extensively studied, but most of the circuits only have learning functions plus forgetting function, and lack emotional function and feature memory. This leads to not be realistic enough for simulating Pavlovian circuit experiments. In this paper, we simulate learning and three forgetting processes on the classic Pavlov circuit, which is consistent with the brain's forgetting mechanism. Then, we add feature memory part, which includes an emotion module, synapse modules, and feature switch modules. The emotion module with positive and negative emotion functions has different effects on memory time, so as to improve its imitating ability of human emotional behavior. The synapse modules and feature switching modules realize different feature memory for different things, so as to promote the circuit's associative memory ability to be more realistic. Through these improvements, the function of the Pavlov dog experiment circuit is more similar to biological mechanism. Furthermore, the LTSPICE software is used to verify the correctness of the proposed circuit.
Soft charging and fewer switches based single‐source double‐boost multilevel DC‐AC converter for low/medium voltage applications
Authors: Tiwari Anurag , Agarwal Ruchi 
Published: July 2024

AbstractThis paper presents a novel generalized step‐up switched‐capacitor multilevel inverter (SCMLI) appropriate for low/medium voltage input applications. To reduce the overall number of power switches, the suggested topology makes use of reduction switch count (SC) technology. The complementary working mechanism of each pair of switches simplifies the modulation method. The complete inductive‐load capability is taken into account in the proposed inverter. Furthermore, because capacitor voltages are automatically balanced, complex voltage control circuitry is not necessary. Due to a reduction in current spikes on the devices, the topology also has the ability to soft‐charge the capacitors in a quasi‐resonant manner. Performance is also enhanced by extending the lifetime and dependability of the inverters. The construction, operation, modulation method, values of the capacitors, and circuit losses are explained to demonstrate how the suggested topology should function. One of the inverter's primary differentiators from the others is its double‐boosting capability based on reduced components. Based on loss calculations, a thorough analysis of the suggested topology's efficiency of 98.31% is presented. Next, the benefits of the suggested inverter are compared to those of other inverters that have been recently suggested. The steady‐state and dynamic performance of the suggested topology is then confirmed by modeling the system on the Simulink platform and performing experiments using a DSP‐based prototype experimental setup.