bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: A Versatile and Efficient Palladium‐meta‐Terarylphosphine Catalyst for the Copper‐Free Sonogashira Coupling of (Hetero‐)Aryl Chlorides and Alkynes.
Authors: Yang Yong , Chew Xinying , Johannes Charles W. , Robins Edward G. , Jong Howard , Lim Yee Hwee 
Published: March 2015

AbstractThe novel title ligand TAP, when combined in situ with a Pd‐source [cf.
ChemInform Abstract: Rhodium‐Catalyzed Oxidative Perfluoroalkenylation by Carbonyl Group Directed C—H Bond Activation.
Authors: Kathiravan Subban , Nicholls Ian A. 
Published: March 2015

AbstractA broad spectrum of substrates bearing a cyclic or acyclic keto function can be used in the title reaction with esters (II), (VII), and (XVIII).
ChemInform Abstract: A Synthetic and Mechanistic Investigation into the Cobalt(I) Catalyzed Amination of Aryl Halides.
Authors: Brennan Marshall R. , Kim Dongyoung , Fout Alison R. 
Published: March 2015

AbstractThe first Co(I)‐catalyzed amination of unactivated aryl iodides with (TMS)2NLi for the formation of anilines, including those not accessible by other cross‐coupling methods, is described.
ChemInform Abstract: BrettPhos Ligand Supported Palladium‐Catalyzed C—O Bond Formation Through an Electronic Pathway of Reductive Elimination: Fluoroalkoxylation of Activated Aryl Halides.
Authors: Rangarajan T. M. , Singh Rajendra , Brahma Raju , Devi Kavita , Singh Rishi Pal , Singh R. P. , Prasad Ashok K. 
Published: March 2015

AbstractThe optimized conditions allow the fluoroalkoxylation of aryl bromides and chlorides bearing electron withdrawing functional groups.
ChemInform Abstract: Enantioselective C—H Bond Functionalization Triggered by Radical Trifluoromethylation of Unactivated Alkene.
Authors: Yu Peng , Lin Jin‐Shun , Li Lei , Zheng Sheng‐Cai , Xiong Ya‐Ping , Zhao Li‐Jiao , Tan Bin , Liu Xin‐Yuan 
Published: March 2015

AbstractThe first examples of an enantioselective redox‐neutral tandem process providing simultaneous formation of C—CF3 and C—O bonds by functionalization of a C—H bond adjacent to an amide, triggered by CF3‐radical addition to an alkene.
ChemInform Abstract: A Green Protocol for the N‐Formylation of Amines Using Molybdate Sulfuric Acid as a Reusable Solid Catalyst.
Authors: Karami Bahador , Farahi Mahnaz , Pam Fariba 
Published: March 2015

AbstractThe method succeeds using aliphatic primary and secondary as well as aromatic primary amines except sterically hindered ones such as diphenylamine or tert‐butyl amine.
ChemInform Abstract: Copper‐Catalyzed Acyloxylation of the C(sp3)—H Bond Adjacent to an Oxygen by a Cross‐Dehydrogenative Coupling Approach.
Authors: Raju Kammari Bal , Kumar Bejjanki Naveen , Nagaiah Kommu 
Published: March 2015

AbstractThe acyloxylation of ethers succeeds with variously substituted benzylic alcohols, but fails using aliphatic alcohols such as butyl or allyl alcohol.
ChemInform Abstract: A Mild and Fast Photocatalytic Trifluoromethylation of Thiols in Batch and Continuous‐Flow.
Authors: Straathof Natan J. W. , Tegelbeckers Bart J. P. , Hessel Volker , Wang Xiao , Noel Timothy 
Published: March 2015

AbstractSome of the presented reactions are also performed using continuous‐flow instead of batch techniques in significantly reduced reaction times, but with varying yields.
ChemInform Abstract: Palladium‐Catalyzed Direct Thiolation of Ethers with Sodium Sulfinates.
Authors: Guo Shengrong , He Weimin , Xiang Jiannan , Yuan Yanqin 
Published: March 2015

AbstractA new, simple, and mild method for the synthesis of aryl alkyl sulfides from ethers and sodium sulfinate is developed.
ChemInform Abstract: Lossen Rearrangements under Heck Reaction Conditions.
Authors: Abdel Hafez El‐Shimaa M. N. , Aly Omar M. , Abuo‐Rahma Gamal El‐Din A. A. , King S. Bruce 
Published: March 2015

AbstractThe Lossen rearrangement of aromatic hydroxamic acids under Heck conditions affords the corresponding aryl amines while aliphatic and hetaryl hydroxamic acids yield symmetric ureas.
ChemInform Abstract: Triphyrin Catalyzed Direct C—H Arylation of Benzene with Aryl Halides.
Authors: Xue Zhao‐Li , Qian Ying Ying , Chan Kin Shing 
Published: March 2015

AbstractPhenyl iodide and aryl iodides equipped with electron‐donating groups react smoothly to afford biaryls.
ChemInform Abstract: Suzuki—Miyaura Coupling of Aryl Chlorides with Arylboronic Acids Using the Morpholine—NiCl2 Catalyst System.
Authors: Abe Taichi , Mino Takashi , Watanabe Kohei , Sakamoto Masami 
Published: March 2015

AbstractThe coupling of aryl chlorides succeeds with aryl and hetaryl boronic acids and even alkenyl boronic acids, but fails for alkyl boronic acids.
ChemInform Abstract: An Improvement of the Palladium‐Catalyzed [4 + 2] Cycloaddition of o‐(Silylmethyl)benzyl Carbonates with Alkenes.
Authors: Jin Yushu , Ishizuka Kentaro , Kuwano Ryoichi 
Published: March 2015

AbstractTris(4‐methoxy‐3,5‐dimethylphenyl)phosphane is evaluated as the ligand in hitherto unsuccesful Pd‐catalyzed transformations to substituted 1,2,3,4‐tetrahydronaphthalenes.
ChemInform Abstract: Gold(III)‐Catalyzed Enynamine—Cyclopentadiene Cycloisomerization with ChiralityTransfer: An Experimental and Theoretical Study Indicating Involvement of Dual Au(III) Push—Pull Assisted cis—trans Isomerism.
Authors: Wirtanen Tom , Muuronen Mikko , Melchionna Michele , Patzschke Michael , Helaja Juho 
Published: March 2015

AbstractA synthetic approach for asymmetric ring‐fused cyclopentadienes with a chiral carbon at the ring junction is established from chiral enynamines by achiral Au(III) catalysis.
ChemInform Abstract: An Organocatalytic Domino Michael‐Alkylation Reaction: Highly Enantioselective Construction of Spiro‐Cyclopentanoneoxindoles and Tetronic Acid Scaffolds.
Authors: Zhou Jing , Wang Qi‐Lin , Peng Lin , Tian Fang , Xu Xiao‐Ying , Wang Li‐Xin 
Published: March 2015

AbstractThe title reaction of methyleneindolinones with ketoester (II) results in the formation of various spiro‐cyclopentanoneoxindoles which are obtained in high yields, good diastereoselectivities and excellent enantioselectivities via α‐alkylation.
ChemInform Abstract: Titanium Salan Catalysts for the Asymmetric Epoxidation of Alkenes: Steric and Electronic Factors Governing the Activity and Enantioselectivity.
Authors: Talsi Evgenii P. , Samsonenko Denis G. , Bryliakov Konstantin P. 
Published: March 2015

AbstractScreening experiments of titanium salan catalysts show, that electronic effects modulate the catalytic activity, whereas steric effects account for the enantioselectivity of the process.
ChemInform Abstract: Gold Catalyzed Synthesis of Fluorinated Tetrahydrofurans and Lactones.
Authors: Malhotra Deepika , Liu Leping , Wang Weibo , Durham Mallory , Hammond Gerald B. , Xu Bo 
Published: March 2015

AbstractGold‐catalyzed tandem cycloisomerization/fluorination of alkynylic alcohols (I) gives difluoro hydroxyl tetrahydrofurans of type (II).
ChemInform Abstract: Facile Synthesis of Pyrroles via Rh(II)‐Catalyzed Transannulation of 1‐Tosyl‐1,2,3‐triazoles with Silyl or Alkyl Enol Ethers.
Authors: Feng Juan , Wang Yuanhao , Li Qingong , Jiang Renwang , Tang Yefeng 
Published: March 2015

AbstractThe title reaction proceeds with high regioselectivity and provides a wide range of substituted pyrroles.
ChemInform Abstract: Synthesis of Enantiopure Furo[2,3‐b]pyrroles.
Authors: Nair Divya S. , Ibnusaud Ibrahim 
Published: March 2015

AbstractThis diastereo‐ and enantioselective synthesis of dihydroxyhexahydrofuro[2,3‐b]pyrrolones comprises the preparation of the key structural element of physovenine, madindoline and diazoamide A.
ChemInform Abstract: Direct Oxidative Coupling of N‐Acetyl Indoles and Phenols for the Synthesis of Benzofuroindolines Related to Phalarine.
Authors: Tomakinian Terry , Guillot Regis , Kouklovsky Cyrille , Vincent Guillaume 
Published: March 2015

AbstractA novel direct oxidative [3 + 2] coupling of phenols and indoles to give a regioselective formation of benzofuro[3,2‐b]indolines (III) and (V), representing the phalarine core, is developed.
ChemInform Abstract: Synthesis of 7‐Azabicyclo[2.2.1]heptane‐1‐carboxylate via Silver/ThioClickFerrophos‐Catalyzed Asymmetric 1,3‐Dipolar Cycloaddition of Dihydropyrrole Ester with N‐Substituted Maleimide.
Authors: Tada Atsuo , Watanabe Sayo , Kimura Midori , Tokoro Yuichiro , Fukuzawa Shin‐ichi 
Published: March 2015

AbstractThe reaction yields and enantioselectivities achieved in the construction of these substituted pharmacologically relevant scaffolds are neither influenced by electronic nor steric substituent effects.
ChemInform Abstract: Photocatalytic Generation of N‐Centered Hydrazonyl Radicals: A Strategy for Hydroamination of β,γ‐Unsaturated Hydrazones.
Authors: Hu Xiao‐Qiang , Chen Jia‐Rong , Wei Qiang , Liu Feng‐Lei , Deng Qiao‐Hui , Beauchemin Andre M. , Xiao Wen‐Jing 
Published: March 2015

AbstractIrradiation of solutions of β,γ‐unsaturated hydrazones (I), (III), and (V) with blue light LEDs gives the corresponding pyrazoles (II), (IV), and (VI).
ChemInform Abstract: Mechanism and Selectivity of N‐Triflylphosphoramide Catalyzed (3+ + 2) Cycloaddition Between Hydrazones and Alkenes.
Authors: Hong Xin , Kuecuek Hatice Baspinar , Maji Modhu Sudan , Yang Yun‐Fang , Rueping Magnus , Houk K. N. 
Published: March 2015

AbstractBroensted acid‐catalyzed cycloadditions between hydrazones and alkenes give rise to a general approach to pyrazolidines.
ChemInform Abstract: Synthesis of a New Class of Bis Heterocycles.
Authors: Padmavathi Venkatapuram , Sreelatha Tumma , Reddy Putta Ramachandra , Divya Kuppireddygari 
Published: March 2015

Abstractvia 1,3‐dipolar cycloaddition of tosylmethyl isocyanide (III) or diazomethane (V) to oxazolyl‐, thiazolyl‐, and imidazolyl acrylamides
ChemInform Abstract: An Efficient Protocol for the Synthesis of Benzoheterocyclic Compounds via Solid‐State Melt Reaction (SSMR).
Authors: Bakthadoss Manickam , Selvakumar Raman , Srinivasan Jayakumar 
Published: March 2015

AbstractThe method serves for the facile synthesis of biologically active benzothiazoles, benzimidazoles, benzospirothiazoles, and quinoxalines, such as the anti‐tumor agents (IIId,e).
ChemInform Abstract: Polystyrene Resin‐Supported CuI‐Cryptand 22 Complex: A Highly Efficient and Reusable Catalyst for Three‐Component Synthesis of 1,4‐Disubstituted 1,2,3‐Triazoles under Aerobic Conditions in Water.
Authors: Movassagh Barahman , Rezaei Nasrin 
Published: March 2015

AbstractThe catalyst is used for the two‐component Huisgen [3 + 2]‐cycloaddition of alkynes and organic azides as well as the three‐component addition of alkynes, sodium azide and alkyl halides to form triazoles.
ChemInform Abstract: Organocatalysis in Aqueous Micellar Medium: A New Protocol for the Synthesis of [1,2,4]‐Triazolyl‐thiazolidinones.
Authors: Singh Mandavi , Saquib Mohammad , Singh Shyam Babu , Singh Swastika , Ankit Preyas , Fatma Shahin , Singh Jagdamba 
Published: March 2015

AbstractThe presented efficient method for the synthesis of biologically relevant hybrid triazolyl‐thiazolidinones is environmentally benign.
ChemInform Abstract: Transient Protection of Strained Alkynes from Click Reaction via Complexation with Copper.
Authors: Yoshida Suguru , Hatakeyama Yasutomo , Johmoto Kohei , Uekusa Hidehiro , Hosoya Takamitsu 
Published: March 2015

AbstractThe strained alkyne moiety of a cyclooctyne can be transiently masked through complexation with a copper(I) salt, thus enabling the selective copper‐catalyzed click conjugation with an azide at the terminal alkyne.
ChemInform Abstract: Synthesis and Biological Evaluation of New Oxadiazoline‐Substituted Naphthalenyl Acetates as Anticancer Agents.
Authors: Chaaban Ibrahim , El Khawass El Sayeda M. , Abd El Razik Heba A. , El Salamouni Nehad S. , Redondo‐Horcajo Mariano , Barasoain Isabel , Diaz J. Fernando , Yli‐Kauhaluoma Jari , Moreira Vania M. 
Published: March 2015

AbstractAll new oxadiazoline‐substituted naphthalenyl acetates (III), (V) are tested for their in vitro anticancer activity.
ChemInform Abstract: Broensted Acid/Lewis Acid Cooperatively Catalyzed Addition of Diazoesters to 2H‐Chromene Acetals.
Authors: Luan Yi , Qi Yue , Gao Hongyi , Ma Qianqian , Schaus Scott E. 
Published: March 2015

AbstractThe title reaction gives oxocarbenium precursors under mild conditions.
ChemInform Abstract: L‐Proline‐Catalyzed Unusual Product Formation from the Reaction of 4‐ Hydroxydithiocoumarin and Aldehydes Through a Pseudo‐Three‐Component Reaction.
Authors: Mahato Karuna , Ray Bagdi Prasanta , Khan Abu T. 
Published: March 2015

AbstractThe structure of the hitherto unknown compounds synthesized by an efficient protocol is proven by X‐ray analysis.
ChemInform Abstract: Oxidative Aromatization of Hantzsch 1,4‐Dihydropyridines by Cupric Bromide under Mild Heterogeneous Condition.
Authors: Saikh Forid , De Rimpa , Ghosh Somnath 
Published: March 2015

AbstractIn contrast to previously published procedures, this protocol does not only tolerate aryl, but also alkyl substituents.
ChemInform Abstract: Co(II), a Catalyst for Selective Conversion of Phenyl Rings to Carboxylic Acid Groups.
Authors: Sinha Shashi Bhushan , Campos Jesus , Brudvig Gary W. , Crabtree Robert H. 
Published: March 2015

AbstractThe Co(II)‐catalyzed oxidative conversion of the phenyl ring in aryl‐substituted pyridines using Oxone as oxidant is studied.
ChemInform Abstract: Metal‐Free Synthesis of Substituted Pyridines from Aldehydes and NH4OAc under Air.
Authors: Yan Rulong , Zhou Xiaoqiang , Li Ming , Li Xiaoni , Kang Xing , Liu Xingxing , Huo Xing , Huang Guosheng 
Published: March 2015

AbstractWhereas substituted 2‐aryl propanals yield 3,5‐diarylpyridines, substituted 3‐aryl propanals react to 3,5‐diarylmethyl‐2‐(arylethyl)pyridines.
ChemInform Abstract: Synthesis of Substituted Quinoline via Copper‐Catalyzed One‐Pot Cascade Reactions of 2‐Bromobenzaldehydes with Aryl Methyl Ketones and Aqueous Ammonia.
Authors: Li Bin , Guo Chenhao , Fan Xuesen , Zhang Ju , Zhang Xinying 
Published: March 2015

AbstractThe reaction fails using aliphatic methyl ketones such as acetone, but succeeds with excellent efficiency for aromatic methyl ketones, thus providing an alternative approach to synthetically and medicinally relevant aryl‐substituted quinolines.
ChemInform Abstract: Synthesis of Substituted Quinolines via Allylic Amination and Intramolecular Heck‐Coupling.
Authors: Murru Siva , McGough Brandon , Srivastava Radhey S. 
Published: March 2015

AbstractThe method also succeeds for the preparation of a bis‐heterocyclic product (XIII) representing a derivative of medicinally relevant 1,5‐naphthyridines.
ChemInform Abstract: Keteniminium Ion‐Initiated Cascade Cationic Polycyclization.
Authors: Theunissen Cedric , Metayer Benoit , Henry Nicolas , Compain Guillaume , Marrot Jerome , Martin‐Mingot Agnes , Thibaudeau Sebastien , Evano Gwilherm 
Published: March 2015

AbstractA highly efficient keteniminium‐initiated cationic polycyclization is developed.
ChemInform Abstract: Domino Synthesis of Fused Hexacyclic Imidazoquinolinoacridinones Catalyzed by CuI/l‐Proline.
Authors: Li Chao , Zhang Wen‐Ting , Wang Xiang‐Shan 
Published: March 2015

AbstractThe one‐pot procedure provides access to hexacyclic skeletons with two newly formed heterocycles and six newly formed bonds.
ChemInform Abstract: TBHP‐Promoted Sequential Carboxamidation and Aromatisation of Aryl Isonitriles with Formamides.
Authors: Feng Xiaomei , Zhu Hui , Wang Lei , Jiang Yan , Cheng Jiang , Yu Jin‐Tao 
Published: March 2015

AbstractThis efficient method for the synthesis of phenanthridine‐6‐carboxamides tolerates a range of functional groups and succeeds with formamides deriving from secondary cyclic and secondary acyclic aliphatic amino moieties.
ChemInform Abstract: SnO Nanoparticles as an Efficient Catalyst for the One‐Pot Synthesis of Chromeno[2,3‐b]pyridines and 2‐Amino‐3,5‐dicyano‐6‐sulfanyl Pyridines.
Authors: Safaei‐Ghomi Javad , Shahbazi‐Alavi Hossein , Heidari‐Baghbahadorani Elham 
Published: March 2015

AbstractThe catalyst is recycled and reused for five times without significant loss of activity.
ChemInform Abstract: Glyoxylic Acid in the Reaction of Isatoic Anhydride with Amines: A Rapid Synthesis of 3‐(Un)substituted Quinazolin‐4(3H)‐ones Leading to Rutaecarpine and Evodiamine.
Authors: Rao K. Raghavendra , Raghunadh Akula , Mekala Ramamohan , Meruva Suresh Babu , Pratap T. V. , Krishna T. , Kalita Dipak , Laxminarayana Eppakayala , Prasad Bagineni , Pal Manojit 
Published: March 2015

AbstractGlyoxylic acid (II) serves as a reactant and the catalyst, thus playing a dual role in this novel and robust metal‐free reaction.
ChemInform Abstract: Polyethylene Glycol (PEG‐400): An Efficient Green Reaction Medium for the Synthesis of Benzo[4,5]imidazo[1,2‐a]‐pyrimido[4,5‐d]pyrimidin‐4(1H)‐ones under Catalyst‐Free Conditions.
Authors: Veeranarayana Reddy Mudumala , Kim Jong Su , Lim Kwon Taek , Jeong Yeon Tae 
Published: March 2015

AbstractA simple protocol for the synthesis of the title species via three‐component reaction of amine (I), aromatic aldehydes (II), and 2‐cyanoacetamide (III).
ChemInform Abstract: New MCR Based on Intramolecular Heck Reaction under Aerobic Conditions: A Direct Access to Cytotoxic Fused N‐Heterocycles.
Authors: Adepu Raju , Prasad Bagineni , Ashfaq Mohd Ashraf , Ehtesham Nasreen Z. , Pal Manojit 
Published: March 2015

AbstractTitle compounds are prepared from isatoic anhydride (I), aromatic 2‐bromo‐substituted arylaldehydes, and allyl amine.
ChemInform Abstract: 1,1′‐Sulfinyldipyridinium Bis (Hydrogen Sulfate) Ionic Liquid: Synthesis and Application in the Temperature‐Influenced Synthesis of Novel Pyranopyrimidinediones and Pyranopyrimidinetriones.
Authors: Patil Jayavant D. , Korade Suyog N. , Pore Dattaprasad M. 
Published: March 2015

AbstractAt ambient temperature the reaction between 6‐amino uracil (I) and salicylaldehydes in ethanol provides pyranopyrimidinediones [cf.
ChemInform Abstract: Switching Between Reaction Pathways by an Alcohol Cosolvent Effect: SmI2—Ethylene Glycol vs SmI2—H2O Mediated Synthesis of Uracils.
Authors: Szostak Michal , Spain Malcolm , Sautier Brice , Procter David J. 
Published: March 2015

AbstractThe SmI2‐mediated reduction of barbituric acids using ethylene glycol as coordinating co‐solvent is followed by a 1,2‐migration process to give 6‐substituted uracils (II) and (IV).
ChemInform Abstract: One‐Pot Synthesis of 1H‐Pyrazolo[1,2‐b]phthalazine‐5,10‐dione Derivatives under Solvent‐Free Conditions.
Authors: Ghorbani‐Vaghei Ramin , Noori Samira , Toghraei‐Semiromi Zahra , Salimi Zahra 
Published: March 2015

AbstractThe catalyst is recovered and reused without decreasing the yield of the products.
ChemInform Abstract: 2,1‐Benzothiazine 2,2‐Dioxides. Part 5. Hydrolysis of Alkyl 1‐R‐4‐Hydroxy‐2,2‐dioxo‐1H‐2λ 6,1‐benzothiazine‐3‐carboxylates.
Authors: Ukrainets I. V. , Petrushova L. A. , Dzyubenko S. P. , Yangyang Liu 
Published: March 2015

AbstractHydrolysis of the title benzothiazinecarboxylates (I) is accompanied by decarboxylation both in acidic and alkaline medium.
ChemInform Abstract: Synthesis, Characterization and Antimicrobial Activity of 2‐(11‐Oxodibenzo[b,f][1,4]thiazepin‐10(11H)‐yl)‐N (Substituted Phenyl) Acetamide Derivatives.
Authors: Tailor Jitesh H. , Patel Priti C. , Malik G. M. 
Published: March 2015

AbstractMost of the title compounds (III) (13 examples) show considerable activity against E.
ChemInform Abstract: Synthesis of Nor‐sesquiterpene Spirolactones and Their Steroidal Hybrids Revisited. The Neopentyl Dilemma: Misassignment of One Stereocentre May Necessitate a Completely New Approach.
Authors: Safir Imad , Chanu Angeline , Elkhayat Zobida , Basak Ramkrishna , Arseniyadis Simeon 
Published: March 2015

AbstractThe correct C1 configuration in natural pathylactone A (I) is clarified.
ChemInform Abstract: Sequential Biocatalytic Aldol Reactions in Multistep Asymmetric Synthesis: Pipecolic Acid, Piperidine and Pyrrolidine (Homo)Iminocyclitol Derivatives from Achiral Building Blocks.
Authors: Soler Anna , Garrabou Xavier , Hernandez Karel , Gutierrez Mariana L. , Busto Eduardo , Bujons Jordi , Parella Teodor , Joglar Jesus , Clapes Pere 
Published: March 2015

AbstractTwo consecutive enzymatic and asymmetric aldol reactions allow the synthesis of stereodefined pipecolic acid (I), piperidine, and pyrrolidine (homo)iminocyclitol [(II) and (III)] derivatives from dimethoxy acetaldehyde and glycine.
How Many Molecules Does It Take to Tell a Story? Case Studies, Language, and an Epistemic View of Medicinal Chemistry
Authors: Stahl Martin , Baier Sabine 
Published: March 2015

AbstractMedicinal chemistry has always been closer to the arts than other disciplines in the natural sciences. Instead of searching for natural laws, medicinal chemistry creates new molecular entities entailing desired pharmaceutical characteristics. While the productive output of medicinal chemistry is comprehensively documented, the epistemic paths of the creative process are less well described. Here we show how such paths could be visualized and how these visualizations relate to images developed in the history and philosophy of science. Based on the discussion of these visualizations, we argue that there is a need for a new language of creativity that can be employed during the very course of research, as opposed to its retrospective analysis. This language should be able to reflect both the status and directions in highly complex research processes that may have a clear goal, yet must remain open to unexpected moments of serendipity.
Finite element simulation of the insertion of guidewires during an EVAR procedure: example of a complex patient case, a first step toward patient‐specific parameterized models
Authors: Gindre Juliette , Bel‐Brunon Aline , Kaladji Adrien , Duménil Aurélien , Rochette Michel , Lucas Antoine , Haigron Pascal , Combescure Alain 
Published: March 2015

SummaryDeformations of the vascular structure due to the insertion of tools during endovascular treatment of aneurysms of the abdominal aorta, unless properly anticipated during the preoperative planning phase, may be the source of intraoperative or postoperative complications. We propose here an explicit finite element simulation method which enables one to predict such deformations. This method is based on a mechanical model of the vascular structure which takes into account the nonlinear behavior of the arterial wall, the prestressing effect induced by the blood pressure and the mechanical support of the surrounding organs and structures. An analysis of the model sensitivity to the parameters used to represent this environment is done. This allows determining the parameters that have the largest influence on the quality of the prediction and also provides realistic values for each of them as no experimental data are available in the literature. Moreover, for the first time, the results are compared with 3D intraoperative data. This is done for a patient‐specific case with a complex anatomy in order to assess the feasibility of the method. Finally, the predictive capability of the simulation is evaluated on a group of nine patients. The error between the final simulated and intraoperatively measured tool positions was 2.1 mm after the calibration phase on one patient. It results in a 4.6 ± 2.5 mm in average error for the blind evaluation on nine patients. Copyright © 2015 John Wiley & Sons, Ltd.
UV Emission of Gd3+ in the Presence of Cu2+: Towards Luminescence Quenching through Quantum Cutting?
Authors: Jiménez José A. 
Published: March 2015

AbstractThe first investigation into the ultraviolet (UV) photoluminescence of gadolinium(III) in the presence of copper(II) is reported. A melt‐quenched barium phosphate glass was used as a model matrix. The optical spectroscopy assessment shows that with increasing CuO concentration the Cu2+ absorption band grows steadily, whereas the UV emission from Gd3+ ions is progressively quenched. The data, thus, suggests the existence of a Gd3+→Cu2+ energy‐transfer process ocurring through quantum cutting. A downconversion/cross‐relaxation pathway proceeding through a virtual state in Gd3+ is proposed. These findings suggest gadolinium(III) could potentially be used in the optical sensing of copper(II).