bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ice-sheet model sensitivities to environmental forcing and their use in projecting future sea level (the SeaRISE project)
Authors: Bindschadler Robert A. , Nowicki Sophie , Abe-Ouchi Ayako , Aschwanden Andy , Choi Hyeungu , Fastook Jim , Granzow Glen , Greve Ralf , Gutowski Gail , Herzfeld Ute , Jackson Charles , Johnson Jesse , Khroulev Constantine , Levermann Anders , Lipscomb William H. , Martin Maria A. , Morlighem Mathieu , Parizek Byron R. , Pollard David , Price Stephen F. , Ren Diandong , Saito Fuyuki , Sato Tatsuru , Seddik Hakime , Seroussi Helene , Takahashi Kunio , Walker Ryan , Wang Wei Li 
Published: March 2013

AbstractTen ice-sheet models are used to study sensitivity of the Greenland and Antarctic ice sheets to prescribed changes of surface mass balance, sub-ice-shelf melting and basal sliding. Results exhibit a large range in projected contributions to sea-level change. In most cases, the ice volume above flotation lost is linearly dependent on the strength of the forcing. Combinations of forcings can be closely approximated by linearly summing the contributions from single forcing experiments, suggesting that nonlinear feedbacks are modest. Our models indicate that Greenland is more sensitive than Antarctica to likely atmospheric changes in temperature and precipitation, while Antarctica is more sensitive to increased ice-shelf basal melting. An experiment approximating the Intergovernmental Panel on Climate Change’s RCP8.5 scenario produces additional first-century contributions to sea level of 22.3 and 8.1 cm from Greenland and Antarctica, respectively, with a range among models of 62 and 14 cm, respectively. By 200 years, projections increase to 53.2 and 26.7 cm, respectively, with ranges of 79 and 43 cm. Linear interpolation of the sensitivity results closely approximates these projections, revealing the relative contributions of the individual forcings on the combined volume change and suggesting that total ice-sheet response to complicated forcings over 200 years can be linearized.
A survey of the fern gametophyte flora of Japan: Frequent independent occurrences of noncordiform gametophytes
Authors: Ebihara Atsushi , Yamaoka Asami , Mizukami Naoko , Sakoda Aki , Nitta Joel H. , Imaichi Ryoko 
Published: March 2013

• Premise of the study: Ferns and lycophytes are the only extant land plants with two free‐living generations (sporophytes and gametophytes); hence, a single species may have two different distributions. The distribution of the gametophytes of most fern species, which are much smaller in size than sporophytes, are almost unknown due to the difficulty of identifying gametophytes using morphological characters.• Methods: Twelve quadrats (1 m2 or 0.25 m2), each subdivided into a grid of 100 (10 × 10) or 25 (5 × 5) squares, were used to survey gametophytes in the Japanese Archipelago, where distribution data of sporophytes and “DNA barcodes” for identification of gametophytes have fully been established in previous studies. Collected gametophytes were identified using the plastid rbcL‐a region.• Key results: In total, gametophytes of 38 species in two broad morphological categories (28 cordiform and 10 noncordiform species) were identified among 407 collections. The cordiform gametophytes discovered are without exception accompanied by their conspecific sporophytes at the periphery of the quadrats. On the other hand, the sporophytic counterparts of the noncordiform gametophytes are often not found or are rare around the sites.• Conclusions: This study demonstrates with a regional flora that fern gametophytes do not always co‐occur with sporophytes of the same species. In particular, noncordiform gametophytes tended to occur independently of conspecific sporophytes. This pattern may be due to the capability for indeterminate growth and vegetative reproduction by gemmae in noncordiform gametophytes.
Influence of Pars Plana Vitrectomy on Macular Sensitivity and Morphology in Patients with Branch Retinal Vein Occlusion and Serous Retinal Detachment
Authors: Noma Hidetaka , Funatsu Hideharu , Shimada Katsunori , Mimura Tatsuya 
Published: March 2013

BACKGROUND AND OBJECTIVE:
To evaluate the influence of serous retinal detachment (SRD) on the outcome of pars plana vitrectomy (PPV) for macular edema in patients with branch retinal vein occlusion (BRVO).

PATIENTS AND METHODS:
In an interventional case series, 20 patients (20 eyes) with BRVO and macular edema underwent PPV, including 12 patients with SRD and eight with cystoid macular edema (CME). Microperimetry of the macular region and optical coherence tomography were performed before and 6 months after PPV.

RESULTS:

In both the CME and SRD groups, the mean macular thickness and macular volume decreased significantly from baseline to 3 and 6 months after PPV (all
P
< .01), while visual acuity improved significantly in both groups (both
P
< .01). However, mean macular sensitivity only increased significantly in the SRD group (
P
< .05).

CONCLUSION:
PPV achieves greater improvement of macular sensitivity in BRVO patients with SRD than in those with CME.

[
Ophthalmic Surg Lasers Imaging Retina.
2013;44:160–167]
Disruption of circadian rhythm increases the risk of cancer, metabolic syndrome and cardiovascular disease
Authors: Shanmugam Vignesh , Wafi Amro , Al-Taweel Nawaf , Büsselberg Dietrich 
Published: March 2013

Abstract
Incidents of non-communicable diseases (NCD) like cardiovascular diseases, cancer, diabetes,
and chronic respiratory disease have increased dramatically and are currently the leading causes
of death worldwide. Their rising incidents coincide with the dramatic changes in industrialization
and development of societies over the past few hundred years. Therefore, current lifestyle
practices should be further explored to uncover novel risk factors for certain cancers (i.e. colon,
prostate, and breast cancer), metabolic syndrome (i.e. diabetes and obesity), and cardiovascular
disease (i.e. coronary artery disease). This review discusses how a disruption of the “biological
clock” or circadian rhythms could be involved in the development of these diseases as circadian
rhythms control multiple physiological processes such as wake/sleep cycles, hormonal levels,
body temperature, metabolism, and immune system.
Several environmental factors that disrupt circadian rhythms can be identified including
exposure to artificial light and electromagnetic (EM) waves, unbalanced diet and night shift work.
The mechanisms of how these “chronodisruptors” are associated with NCDs will be discussed.
Furthermore, the involvement of genetic factors in the disturbance of circadian rhythms and
predisposition to NCDs will be highlighted.
Overall there is strong evidence from animal models and epidemiological studies underlining
that circadian disruption is a significant player in several diseases particularly the multifactorial
diseases that pose a significant public health challenge in contemporary society. A circadian
disruption-based model of cancer, metabolic syndrome and cardiovascular disease etiology can
be proposed. But, to fully understand the complex interactions of the different components in the
network of disease development due to disruption of circadian rhythms, more investigations are
needed to unravel the causal relationship between modern lifestyle, circadian rhythm disruption
and complex disease. This summary will help to better understand the mechanisms and aid the
development of new methods and policies to lower incidence/death rates.
La reconversion des friches industrielles en quartiers durables
Authors: Benali Kenza 
Published: March 2013

Dans le contexte actuel de développement urbain durable, la densification du tissu bâti existant s’est imposée comme une solution adéquate pour contrecarrer l’étalement urbain et ses effets néfastes. Les friches industrielles, vastes et souvent bien situées au coeur des villes, constituent à cet égard un potentiel de développement majeur. Ces espaces sous-utilisés sont depuis peu la cible privilégiée pour la réalisation d’écoquartiers ou de « quartiers durables ». D’abord développés dans les pays d’Europe du Nord, ces quartiers modèles ont par la suite connu une diffusion européenne et nord-américaine. Si, de manière générale, ils ont reçu un accueil favorable et ont connu une popularité grandissante en raison de leurs promesses et de leur urbanisme « vertueux », il reste que de grandes lignes critiques apparaissent dans la littérature spécialisée. Cet article vise d’abord à définir, à travers une revue de la littérature récente, ce mouvement actuel en aménagement, puis à évoquer les principales critiques qui lui sont adressées.
Mesurer l’accessibilité territoriale par les transports collectifs
Authors: Richer Cyprien , Palmier Patrick 
Published: March 2013

L’accessibilité n’est pas un concept univoque. Si toutes les approches insistent sur l’enjeu du « potentiel de mobilité » pour l’espace et les sociétés, il convient de distinguer les multiples dimensions du système d’accessibilité territoriale (approche théorique). Cet article porte sur une de ses facettes, celle de l’accessibilité structurelle du territoire en transport collectif à travers la construction d’un indicateur multicritère (croisement de critères de temps, d’intensité des relations et de pénibilité des déplacements). L’enjeu est d’estimer plus finement des potentiels d’accessibilité en transport collectif (approche méthodologique) et d’interpréter (approche opérationnelle) les (dés)équilibres d’accès aux pôles d’excellence dans le territoire métropolitain lillois. Les résultats fournis par l’outil de calcul de l’accessibilité multimodale MUSLIW, développé au CETE Nord-Picardie, permettent de mettre en débat les politiques stratégiques de la Communauté urbaine de Lille Métropole (LMCU) dans une optique d’aide à la décision. La démarche élaborée dans cet article est mise en perspective avec la méthode anglo-saxonnePublic Transport Accessibility Level(PTAL) utilisée dans la planification stratégique au Royaume-Uni. Ce croisement des regards donne la mesure de l’enjeu d’une meilleure estimation de la performance territoriale des réseaux de transport collectif pour assister les autorités responsables de l’aménagement, par exemple, dans leur choix d’urbanisation et de normes de stationnement.
An Efficient and Recyclable Catalyst for N‐Alkylation of Amines and β‐Alkylation of Secondary Alcohols with Primary Alcohols: SBA‐15 Supported N‐Heterocyclic Carbene Iridium Complex
Authors: Wang Dong , Guo Xu‐Qing , Wang Chen‐Xi , Wang Ya‐Nong , Zhong Rui , Zhu Xiao‐Han , Cai Li‐Hua , Gao Zi‐Wei , Hou Xiu‐Feng 
Published: March 2013

AbstractA mesoporous silica (SBA‐15)‐supported pyrimidine‐substituted N‐heterocyclic carbene iridium complex was prepared and used as a catalyst for both environmentally friendly N‐alkylation of amines and β‐alkylation of secondary alcohols with primary alcohols. The structure of the supported iridium catalyst was characterized by Fourier transform infrared (FT‐IR), 13C and 29Si solid‐state nuclear magnetic resonance (NMR), small‐angle X‐ray scattering (SAXS), transmission electron microscopy (TEM), iridium K‐edge X‐ray absorption near‐edge structure (XANES) and extended X‐ray absorption fine structure (EXAFS) spectroscopic analyses which demonstrated that the coordination environment of the iridium centre and the 3‐dimensional‐hexagonal pore structure of SBA‐15 were retained after the immobilization. The catalyst was found to be highly efficient for both kinds of reaction on a wide range of substrates under mild conditions. Moreover, the supported iridium catalyst was obviously superior to the unsupported one in the N‐alkylation of aniline and β‐alkylation of 1‐phenylethanol with benzyl alcohol as substrate, which indicated that not only the iridium complex moiety but also the support material contributed to the catalytic activity of the supported iridium catalyst in these reactions. The supported iridium catalyst can be easily recycled by simple washing without chemical treatment, and exhibited excellent recycling performance without notable decrease in catalytic efficiency even after twelve test cycles for N‐alkylation of aniline with benzyl alcohol, nine cycles for N‐alkylation of different amines with different alcohols, and eight cycles for β‐alkylation of 1‐phenylethanol with benzyl alcohol, respectively.
Tuning the Peri Effect for Enantioselectivity: Asymmetric Hydrogenation of Unfunctionalized Olefins with the BIPI Ligands
Authors: Busacca Carl A. , Qu Bo , Grět Nicole , Fandrick Keith R. , Saha Anjan K. , Marsini Maurice , Reeves Diana , Haddad Nizar , Eriksson Magnus , Wu Jiang‐Ping , Grinberg Nelu , Lee Heewon , Li Zhibin , Lu Bruce , Chen Dajun , Hong Yaping , Ma Shengli , Senanayake Chris H. 
Published: March 2013

AbstractThe modular nature of the BIPI ligands allows for systematic optimization of each ligand region. The development of ligands optimized for asymmetric hydrogenation of the challenging unfunctionalized olefin substrate class is described. The naphthyl peri position, C‐8, has been identified as a critical stereocontrol element in the design of these ligands. Highly enantioselective ligands suitable for hydrogenation of tri‐ and tetrasubstituted olefins are detailed.
Controlling Metallurgical Phase Separation Reactions of the Ge0.87Pb0.13Te Alloy for High Thermoelectric Performance
Authors: Gelbstein Yaniv , Davidow Joseph , Girard Steven N. , Chung Duck Young , Kanatzidis Mercouri 
Published: March 2013

AbstractWe demonstrate the potential of metallurgical controlling of the phase separation reaction, by means of spark plasma sintering consolidation and subsequently controlled heat treatments sequence, for enhancement the thermoelectric properties of the p‐type Ge0.87Pb0.13Te composition. Very high ZTs of up to ∼2, attributed to the nucleation of sub‐micron phase separation domains and to comparable sized twinning and dislocation networks features, were observed. Based on the experimentally measured transport properties, combined with the previously reported phase separated n‐type (Pb0.95Sn0.05Te)0.92(PbS)0.08 composition, a maximal efficiency value of ∼11.5% was theoretically calculated. These ZT and efficiency values are among the highest reported for single composition non‐segmented bulk material legs.
Management of sinonasal chondrosarcoma: a systematic review of 161 patients
Authors: Khan Mohemmed N. , Husain Qasim , Kanumuri Vivek V. , Boghani Zain , Patel Chirag R. , Liu James K. , Eloy Jean Anderson 
Published: March 2013

BackgroundThis study reviews the published literature related to management of sinonasal chondrosarcoma. Clinical presentation, demographics, radiographic diagnosis, treatment, and management outcomes of this uncommon disease are reported.MethodsA systematic review of studies for sinonasal chondrosarcoma from 1950 to 2012 was conducted. A PubMed search for articles related to this condition, along with bibliographies of the selected articles was performed. Articles were examined for patient data that reported survivability. Demographic data, disease site, treatment strategies, follow‐up, outcome, and survival were analyzed.ResultsA total of 63 journal articles were included, comprising a total of 161 cases of sinonasal chondrosarcoma. The average follow‐up was 77.4 months (range, 1 to 325.2 months). Surgical resection was the most common treatment modality, used in 72.0% of cases. A combination of surgery and radiation therapy was the second most commonly used treatment modality, used in 21.7% of cases.ConclusionThis review contains the largest pool of sinonasal chondrosarcoma patients to date and suggests aggressive surgical resection is the most common treatment modality for this condition. The use of adjuvant radiotherapy for prevention of local recurrence after subtotal or total resection has not been proven effective. However, the use of radiotherapy in addition to surgical resection has shown benefit in some studies in terms of survival.
Mucosal brush biopsy of the oral cavity to detect local, peanut‐specific immunoglobulin E
Authors: Reisacher William R. , Cohen Justin C. 
Published: March 2013

BackgroundThis study compares the ability of mucosal brush biopsy (MBB) from 2 separate locations in the oral cavity to detect peanut‐specific immunoglobulin E (IgE) in patients who report adverse oral cavity reactions when ingesting peanuts.MethodsTwenty patients who reported a history of oral cavity itching or swelling when ingesting peanuts underwent either MBB of the dorsal tongue (n = 10) or the vestibule (n = 10). Serum testing for total and peanut‐specific IgE, using standard immunofluorescent assay, was obtained for all patients. Total and specific IgE for each location were compared. Additionally, the correlation between MBB and peanut‐specific IgE on serum was determined using Fisher's exact probability testing.ResultsPeanut‐specific IgE was detected in 3 of 10 (30%) MBB specimens from the dorsal tongue and in 10 of 10 (100%) MBB specimens from the vestibule. The mean peanut‐specific IgE on MBB (kU/L) in the dorsal tongue group was 0.03 vs 0.17 in the vestibule group (p = 0.0002). No significant association was noted for peanut‐specific IgE between MBB and serum testing (p = 1.0).ConclusionThis study demonstrates for the first time that peanut‐specific IgE can be detected using MBB in the oral cavity of patients who are symptomatic when consuming peanuts. The vestibule was a superior location compared to the dorsal tongue for oral cavity MBB, correlating very well with self‐reported symptoms. Peanut‐specific IgE on MBB overall did not correlate well with serum testing for peanut‐specific IgE.
Fabrication of transition‐metal‐doped polypyrrole/multiwalled carbon nanotubes nanocomposites for supercapacitor applications
Authors: Dhibar Saptarshi , Sahoo Sumanta , Das C. K. 
Published: March 2013

AbstractCopper chloride (CuCl2)‐doped polypyrrole (PPy)/multiwalled carbon nanotube (MWCNTs) nanocomposites were synthesized by an in
situ oxidative polymerization method with ammonium persulfate as the oxidant in HCl medium and investigated as electrode materials for supercapacitors. The interaction of metal cations (Cu2+ ions) with PPy was confirmed by Fourier transform infrared spectroscopic analysis. The morphology of the nanocomposites was characterized by field emission scanning electron microscopy and high‐resolution transmission electron microscopy. Electrochemical characterizations of the composites materials were carried out by a three‐electrode probe method, where platinum and a saturated standard calomel electrode were used as the counter and reference electrodes, respectively. A 1M KCl solution was used as the electrolyte for all of the electrochemical characterizations. The transition‐metal‐ion doping enhanced the electrochemical properties of the conducting polymer. Among all of the composites, the CuCl2‐doped PPy/MWCNTs showed the highest specific capacitance value of 312 F/g at a 10 mV/s scan rate. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Orientation of HDPE inclusions within solid‐state drawn rubber‐modified isotactic polypropylene: DSC insight
Authors: Sližová Marta , Raab Miroslav 
Published: March 2013

AbstractEffect of drawing temperature on the melting behavior of oriented isotactic polypropylene (PP) modified with ethylene‐propylene‐diene monomer rubber with a small amount of high‐density polyethylene (HDPE) is explored in this study. Injection‐molded specimens both neat and 8 vol % modified PP were solid‐state drawn to natural drawing ratio and characterized by X‐ray diffraction, dynamic mechanical analysis (DMA), Charpy impact test and differential scanning calorimetry (DSC). A synergy of orientation and embedding rubber particles caused a significant increase of low‐temperature notched impact strength of oriented blends. It was shown, that the DSC method can be used successfully for the indirect but very sensitive characterization of orientation on a nanometre scale. At the drawing temperature of 120°C, the DSC data indicated an incomplete transition of the PP crystalline structure: This is reflected by splitting and shifting of the melting peak of PP. An increase of the melting temperature of the HDPE inclusions by 3.5°C reflects the high orientation. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Opposite Modulation of Cell Migration by Distinct Subregions of Urokinase Connecting Peptide
Authors: Franco Paola , Carotenuto Alfonso , Marcozzi Cristina , Votta Giuseppina , Sarno Ciro , Iaccarino Ingram , Brancaccio Diego , De Vincenzo Anna , Novellino Ettore , Grieco Paolo , Stoppelli Maria Patrizia 
Published: March 2013

AbstractFunctional analysis of isolated protein domains may uncover cryptic activities otherwise missed. The serine protease urokinase (uPA) has a clear‐cut motogen activity that is catalytically independent and resides in its amino‐terminal growth factor domain (GFD, residues 1‐49) and connecting peptide region (CP, residues 132–158). To functionally dissect the CP region, we analysed the biological activity of two synthetic peptides corresponding to the N‐terminal [uPA‐(135–143), residues 135–143] and C‐terminal [uPA‐(144–158), residues 144–158] CP subregions. Most of the chemotactic activity of connecting peptide‐derived peptide (CPp, [uPA‐(135–158)]) for embryonic kidney HEK293/uPAR‐25 cells is retained by uPA‐(144–158) at nanomolar concentrations. In contrast, uPA‐(135–143) inhibits basal, CPp ‐, vitronectin‐ and fibronectin‐induced cell migration. Radioreceptor binding assays on intact HEK293 cells revealed that uPA‐(135–143) and uPA‐(144–158) are both able to compete with [125I]‐CPp, albeit with different binding affinities. The consequences of phospho‐mimicking, S138E substitution, were studied using [138E]uPA‐(135–158) and [138E]uPA‐(135–143) peptides. Unlike CPp, [138E]uPA‐(135–158) and [138E]uPA‐(135–143) exhibit remarkable inhibitory properties. Finally, analysis of the conformational preferences of the peptides allowed to identify secondary structure elements exclusively characterising the stimulatory CPp and uPA‐(144–158) versus the inhibitory uPA‐(135–143), [138E]uPA‐(135–158) and [138E]uPA‐(135–143) peptides. In conclusion, these data shed light on the cryptic activities of uPA connecting peptide, revealing the occurrence of two adjacent regions, both competing for binding to cell surface but conveying opposite signalling on cell migration.
Magnetic Anisotropy of Cyanide‐Bridged Core and Core–Shell Coordination Nanoparticles Probed by X‐ray Magnetic Circular Dichroism
Authors: Prado Yoann , Arrio Marie‐Anne , Volatron Florence , Otero Edwige , Cartier dit Moulin Christophe , Sainctavit Philippe , Catala Laure , Mallah Talal 
Published: March 2013

AbstractThe local symmetry and local magnetic properties of 6 nm‐sized, bimetallic, cyanide‐bridged CsNiCr(CN)6 coordination nanoparticles 1 and 8 nm‐sized, trimetallic, CsNiCr(CN)6@CsCoCr(CN)6 core–shell nanoparticles 2 were studied by X‐ray absorption spectroscopy (XAS) and X‐ray magnetic circular dichroism (XMCD). The measurements were performed at the NiII, CoII, and CrIII L2,3 edges. This study revealed the presence of distorted NiII sites located on the particle surface of 1 that account for the uniaxial magnetic anisotropy observed by SQUID measurements. For the core–shell particles, a combination of the exchange anisotropy between the core and the shell and the pronounced anisotropy of the CoII ions is the origin of the large increase in coercive field from 120 to 890 Oe on going from 1 to 2. In addition, XMCD allows the relative orientation of the magnetic moments throughout the core–shell particles to be determined. While for the bimetallic particles of 1, alignment of the magnetic moments of CrIII ions with those of NiII ions leads to uniform magnetization, in the core–shell particles 2 the magnetic moments of the isotropic CrIII follow those of CoII ions in the shell and those of NiII ions in the core, and this leads to nonuniform magnetization in the whole nanoobject, mainly due to the large difference in local anisotropy between the CoII ions belonging to the surface and the NiII ions in the core.