bluuebunny/crossref_metadata_2025_split huggingface dataset:
Switching From Tacrolimus to Cyclosporine A to Prevent Primary Biliary Cirrhosis Recurrence After Living-Donor Liver Transplantation
Authors: Shiba Hiroaki , Wakiyama Shigeki , Futagawa Yasuro , Gocho Takeshi , Ito Ryusuke , Furukawa Kenei , Ishida Yuichi , Misawa Takeyuki , Yanaga Katsuhiko 
Published: May 2013

Abstract
Recurrence of primary biliary cirrhosis (PBC) after liver transplantation has been shown to negatively affect graft and patient survival. Recently, protective effects of cyclosporine A against PBC recurrence after liver transplantation have been reported. Participants were 4 patients who underwent living-donor liver transplantation (LDLT) for end-stage liver disease due to PBC. Tacrolimus was used for initial immunosuppression, and this was switched to cyclosporine A at least 3 months after liver transplantation. Targeted trough level of cyclosporine A was 20 times that of tacrolimus. We assessed liver and renal function, as well as antimitochondrial M2 antibody for recipients prior to LDLT, as well as before and after switching immunosuppressive agents. Patients were 1 man and 3 women, and they were ages 45 to 47 years at LDLT. Timing of switching from tacrolimus to cyclosporine A was 13, 3, 7, and 4 months respectively after liver transplantation, and all 4 patients have been on cyclosporine A without adverse effects at 20 to 46 months after transplantation. In 2 of 4 patients who had high titers of antimitochondrial M2 antibody before transplantation, antibody titer did not elevate after LDLT. In the other 2 patients without elevation of antimitochondrial M2 antibody, the titer did not turn positive. Switching from tacrolimus to cyclosporine A was possible without medical problems, and all patients exhibit no recurrence of PBC. Cyclosporine A may be useful for prevention of PBC recurrence after LDLT.
Clinical Analysis of Thyroid Carcinoma Showing Thymus-Like Differentiation: Report of 8 Cases
Authors: Liu Zhen , Teng Xu-Yong , Sun Da-Xin , Xu Wei-Xue , Sun Shao-Long 
Published: May 2013

AbstractThyroid carcinoma showing thymus-like differentiation (CASTLE) is a kind of rare neoplasm of the thyroid gland. Because thyroid CASTLE is rare and difficult to diagnose, its clinicopathologic features have not been well defined, and no universally accepted treatment recommendation is available. We analyzed retrospectively the clinicopathologic data of 8 patients with thyroid CASTLE who underwent surgery and radiotherapy at the Shengjing Hospital of China Medical University between December 2008 and June 2012. All patients accepted radical surgery. All patients accepted postoperative radiotherapy, except one 79-year-old patient. There was no evidence of recurrence or metastasis during the follow-up period. The pattern of immunohistochemical staining was similar to that of thymic carcinoma. Six of 8 CASTLE cases expressed CD5. All 8 CASTLE patients were negatively expressed in thyroglobulin, thyroid transcription factor 1, and calcitonin. Patients with thyroid CASTLE have good outcomes after radical resection and postoperative radiotherapy. Positive CD5 immunoreactivity can contribute to diagnosis of this disease.
Mesothelin Expression Is a Prognostic Factor in Cholangiocellular Carcinoma
Authors: Nomura Ryohei , Fujii Hiroaki , Abe Masaaki , Sugo Hiroyuki , Ishizaki Yoichi , Kawasaki Seiji , Hino Okio 
Published: May 2013

Abstract
Although mesothelin is highly expressed in epithelial mesotheliomas, and also in adenocarcinomas of the ovary and pancreas, the clinical significance of mesothelin in cholangiocellular carcinoma (CC) has not been reported, and its biologic features are largely unknown. In the present study, mesothelin expression was evaluated in 25 patients with CC using a well-characterized mesothelin monoclonal antibody (5B2). A total of 8 of the 25 patients with CC (32%) showed mesothelin immunoreactivity. The 25 patients were divided into 2 groups according to the percentage of tumor cells that were positive for mesothelin expression: negative (n = 17) or focally positive (mesothelin expression evident in less than 50%, n = 4; total, n = 21 for both groups), and positive (mesothelin expression evident in 50% or more, n = 4). The survival periods in both groups were statistically analyzed. The negative/focally positive group showed significantly longer postoperative survival than the positive group (P = 0.006). Also, mesothelin positivity was identified as an independent predictor of short postoperative survival. The present results suggest that mesothelin expression is a prognostic indicator in patients with CC.
Exercise Improves Cognitive Control: Evidence from the Stop Signal Task
Authors: Padilla Concepcion , Perez Laura , Andres Pilar , Parmentier Fabrice B. R. 
Published: May 2013

SummaryThe aim of this study was to test the hypothesis that exercise improves executive control. We compared the performance of physically active and passive young participants in two versions of the stop signal task: a strategic (more executive) and a standard version. The results showed that active participants were more efficient than passive at inhibiting a response in the strategic version, suggesting that (1) physical exercise appears positively associated with improved cognitive control in healthy young participants, adding to evidence gathered in children, aging and clinical populations; and that (2) the strategic version of the stop signal task constitutes a more sensitive task than executive tasks previously used. Although the data point out a link between physical activity and executive control, they also have potential practical implications for health authorities and the general public by strengthening the view that exercise, beyond its physical health benefits, also has positive effects on cognitive functioning. Copyright © 2013 John Wiley & Sons, Ltd.
Mesoporous Calcium Carbonate as a Phase Stabilizer of Amorphous Celecoxib – An Approach to Increase the Bioavailability of Poorly Soluble Pharmaceutical Substances
Authors: Forsgren Johan , Andersson Mattias , Nilsson Peter , Mihranyan Albert 
Published: May 2013

AbstractThe bioavailability of crystalline pharmaceutical substances is often limited by their poor aqueous solubility but it can be improved by formulating the active substance in the amorphous state that is featured with a higher apparent solubility. Although the possibility of stabilizing amorphous drugs inside nano‐sized pores of carbon nanotubes and ordered mesoporous silica has been shown, no conventional pharmaceutical excipients have so far been shown to possess this property. This study demonstrates the potential of using CaCO3, a widely used excipient in oral drug formulations, to stabilize the amorphous state of active pharmaceutical ingredients, in particular celecoxib. After incorporation of celecoxib in the vaterite particles, a five to sixfold enhancement in apparent solubility of celecoxib is achieved due to pore‐induced amorphization. To eliminate the possibility of uncontrolled phase transitions, the vaterite particles are stored in an inert atmosphere at 5 °C throughout the study. Also, to demonstrate that the amorphization effect is indeed associated with vaterite mesopores, accelerated stress conditions of 100% relative humidity are employed to impose transition from mesoporous vaterite to an essentially non‐porous aragonite phase of CaCO3, which shows only limited amorphization ability. Further, an improvement in solubility is also confirmed for ketoconazole when formulated with the mesoporous vaterite. Synthesis of the carrier particles and the incorporation of the active substances are carried out simultaneously in a one‐step procedure, enabling easy fabrication. These results represent a promising approach to achieve enhanced bioavailability in new formulations of Type II BCS drugs.
Dendrimers or Nanoparticles as Supports for the Design of Efficient and Recoverable Organocatalysts?
Authors: Keller Michel , Perrier Arnaud , Linhardt Roland , Travers Laurie , Wittmann Sebastian , Caminade Anne‐Marie , Majoral Jean‐Pierre , Reiser Oliver , Ouali Armelle 
Published: May 2013

AbstractThe Jørgensen–Hayashi catalyst [(S)‐α,α‐diphenylprolinol trimethylsilyl ether] was grafted onto the surface of two different supports: phosphorus dendrimers (generations 1 to 3) and magnetic, polymer‐coated cobalt/carbon (Co/C) nanobeads. These new supported catalysts displayed high activities and selectivities in the Michael additions of a wide range of aldehydes to different nitroolefins. Moreover, the dendrimer of the third generation displayed excellent recycling abilities since it could be recovered and reused in 7 consecutive runs without loss of activity.
Deletion 16p13.11 uncovers NDE1 mutations on the non‐deleted homolog and extends the spectrum of severe microcephaly to include fetal brain disruption
Authors: Paciorkowski Alex R. , Keppler‐Noreuil Kim , Robinson Luther , Sullivan Christopher , Sajan Samin , Christian Susan L. , Bukshpun Polina , Gabriel Stacy B. , Gleeson Joseph G. , Sherr Elliott H. , Dobyns William B. 
Published: May 2013

AbstractDeletions of 16p13.11 have been associated with a variety of phenotypes, and have also been found in normal individuals. We report on two unrelated patients with severe microcephaly, agenesis of the corpus callosum, scalp rugae, and a fetal brain disruption (FBD)‐like phenotype with inherited deletions of 16p13.11. The first patient was subsequently found on whole exome sequencing to have a nonsense mutation (p.R44X) in NDE1 on the non‐deleted chromosome 16 homolog. We then undertook copy number studies of 16p13.11 and sequencing of NDE1 in nine additional patients with a similar severe microcephaly, agenesis of the corpus callosum, and FBD‐like phenotype. The second patient was found to have an inherited deletion of the entire NDE1 gene combined with a frameshift mutation (c.1020‐1021het_delGA) in the non‐deleted NDE1. These observations broaden the phenotype seen in NDE1‐related microcephaly to include FBD. These data also represent the second described syndrome, after Bernard‐Soulier syndrome, where an autosomal recessive condition combines an inherited segmental duplication mediated deletion with a mutation in a gene within the non‐deleted homolog. Finally, we performed informatics analysis of the 16p13.11 gene content, and found that there are many genes within the region with evidence for role(s) in brain development. Sequencing of other candidate genes in this region in patients with deletion 16p13.11 and more severe neurophenotypes may be warranted. © 2013 Wiley Periodicals, Inc.
Cost of outpatient endoscopic sinus surgery from the perspective of the Canadian government: a time‐driven activity‐based costing approach
Authors: Au Jennifer , Rudmik Luke 
Published: May 2013

BackgroundThe time‐driven activity‐based costing (TD‐ABC) method is a novel approach to quantify the costs of a complex system. The aim of this study was to apply the TD‐ABC technique to define the overall cost of a routine outpatient endoscopic sinus surgery (ESS) from the perspective of the Canadian government payer.MethodsCosting perspective was the Canadian government payer. All monetary values are in Canadian dollars as of December 2012. Costs were obtained by contacting staff unions, reviewing purchasing databases and provincial physician fee schedules. Practical capacity time values were collected from the College and Association of Registered Nurses of Alberta. Capacity cost rates ($/min) were calculated for all staff, capital equipment, and hospital space.ResultsThe overall cost for routine outpatient ESS was $3510.31. The cost per ESS case for each clinical pathway encounter was as follows: preoperative holding ($49.19); intraoperative ($3296.60); sterilization ($90.20); postanesthesia care unit ($28.64); and postoperative day ward ($45.68). The 3 major cost drivers were physician fees, disposable equipment, and nursing costs. The intraoperative phase contributed to 94.5% of the overall cost.ConclusionThis study applied the TD‐ABC method to evaluate the cost of outpatient ESS from the perspective of the Canadian government payer and defined the overall cost to be $3510.31 per case.
Biodiversity value of a geographically restricted soft coral species within a temperate estuary
Authors: Poulos Davina E , Harasti David , Gallen Christopher , Booth David J 
Published: May 2013

ABSTRACT

A threatened and uncommon soft coral species, Dendronephthya australis found in large abundance in Port Stephens, within the Port Stephens–Great Lakes Marine Park (PSGLMP), New South Wales, Australia, was hypothesized to be an important habitat for many marine fishes and invertebrates, but is currently under threat from boat anchors, fishing debris entanglement and sand inundation.
Surveys were undertaken to assess the biodiversity associated with the soft coral habitat and its adjacent habitats (sponge, seagrass and unvegetated sand), using a combination of Underwater Visual Census (UVC) and Baited Remote Underwater Video System (BRUVS) techniques.
In total, 77 fish species and 21 invertebrate species utilized the D. australis habitat, and multivariate fish assemblages associated with soft corals were significantly different to those associated with nearby sponges, seagrass and sand habitats. Species richness of fishes and invertebrates were significantly higher in soft coral and sponge habitats than seagrass.
The D. australis habitat was found to be of high importance to juvenile snapper (Pagrus auratus: Sparidae), a species of recreational and commercial fishery importance, which occurred in highest abundance within D. australis, and were significantly smaller in size within the soft coral habitat than the adjacent sponge habitat.
Evidently, this rare soft coral habitat supports an extensive marine assemblage, potentially providing a valuable source of food and shelter for fishes and invertebrates, and given it is threatened by human‐induced impacts, its protection should be a priority. Copyright © 2013 John Wiley & Sons, Ltd.
Intermittent Impulsive Synchronization of Hyperchaos with Application to Secure Communication
Authors: Zhang Hongtao , Liu Xinzhi , Shen Xuemin (Sherman) , Liu Jun 
Published: May 2013

AbstractIn this paper, a hyperchaotic system is presented as the chaotic carrier to encrypt information in secure communication. The sensitivity to the system parameters and delay of the hyperchaotic system, i.e., its chaotic degree indicated by the number of positive Lyapunov exponents, increases with its system parameter and delay, guaranteeing a large enough key space when one selects its system parameter and delay as the secret key. Furthermore, we develop an intermittent impulsive synchronization scheme (IISS) to achieve chaos synchronization, a crucial process in chaos‐based secure communication. In our scheme, impulsive control is only activated in the control windows, not during the whole time, which breaks through the limitation on the upper bound of the impulsive intervals in the general impulsive synchronization scheme (GISS). Specifically, IISS improves the security of the chaos‐based secure communication scheme since the encrypted signal (cipher) is transmitted in the free windows, different from the synchronization signal in the control windows. Finally, a secure communication scheme employing our hyperchaotic system and IISS technique is proposed and numerical results are given to demonstrate the performance of this scheme.
Growth, metabolic activity, and productivity of immobilized and freely suspended CHO cells in perfusion culture
Authors: Hilal‐Alnaqbi Ali , Hu Alan Y. C. , Zhang Zhibing , Al‐Rubeai Mohamed 
Published: May 2013

AbstractChinese hamster ovary (CHO) cells producing β‐galactosidase (β‐gal) were successfully cultured on silicone‐based porous microcarriers (ImmobaSil FS) in a 1 L stirred‐tank perfusion bioreactor. We studied the growth, metabolism, and productivity of free and immobilized cells to understand cellular activity in immobilized conditions. CHO cells attached to ImmobaSil FS significantly better than to other microcarriers. Scanning electron microscope images showed that the CHO cells thoroughly colonized the porous surfaces of the ImmobaSil FS, exhibiting a spherical morphology with microvilli that extended to anchorage cells on the silicone surface. In perfusion culture, the concentration of the attached cells reached 8 × 108 cells/mL of carrier, whereas those that remained freely suspended reached 2 × 107 cells/mL medium. The β‐gal concentration reached more than 5 unit/mL in perfusion culture, more than fivefold that of batch culture. The maximum concentration per microcarrier was proportional to the initial cell density. The specific growth rate, the specific β‐gal production rate, the percentage of S phase, and the oxygen uptake rate were all relatively lower for immobilized cells than freely suspended cells in the same bioreactor, indicating that not only do cells survive and grow to a greater extent in a free suspension state, but they are also metabolically more active than viable cells inside the pores of the microcarriers.
A Transdisciplinary Exploratory Model of Corporate Responses to the Challenges of Environmental Sustainability
Authors: Elliot Steve 
Published: May 2013

ABSTRACTGlobal surveys of business leaders identify the environment as a major issue of concern, but uncertainties about how to address the challenges of environmental sustainability are cited as a significant inhibitor to business responses. Persistent levels of corporate uncertainty in this domain may be due to the complexity of issues and difficulties in meaningfully capturing this complexity. Calls have been made for new ways to produce knowledge about complex societal challenges, including environmental sustainability.This paper aims to reduce business uncertainties and to stimulate business and research initiatives. The paper describes a field study of a global corporation's pioneering responses to environmental sustainability. The study highlights academic and practitioner collaboration to generate, transfer and implement new knowledge through an innovative research approach. The outcome is a transdisciplinary, exploratory model, presenting a progression of integrated activities and processes within eight categories of corporate responses. Implications for research and practice are considered. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment.
ChemInform Abstract: Supramolecular Assembly of Borate with Quaternary Ammonium: Crystal Structure and Tunable Luminescent Properties.
Authors: Liang Jie , Wang Yong‐gang , Wang Ying‐xia , Liao Fu‐hui , Lin Jian‐hua 
Published: May 2013

AbstractThe new borate [iPrNHMe3][B5O6(OH)4] is prepared by hydrothermal reaction of isopropyltrimethylammonium hydroxide with H3BO3 (H2O, 135 °C, 10 d).
ChemInform Abstract: A Neutral, Chiral, Bis(imidazolidine)‐Derived NCN‐Type Palladium Pincer Complex with Catalytic Activity.
Authors: Arai Takayoshi , Oka Ikiyo , Morihata Takuma , Awata Atsuko , Masu Hyuma 
Published: May 2013

AbstractThe well‐organized asymmetric reaction sphere of the title complexes is employed to catalyze the asymmetric reaction of nitroalkenes with malononitrile.
ChemInform Abstract: A New Mild Method for the C‐Acylation of Ketone Enolates. A Convenient Synthesis of β‐Keto‐esters, ‐Thionoesters, and ‐Thioesters.
Authors: Hale Karl J. , Grabski Milosz , Flasz Jakub T. 
Published: May 2013

AbstractA new method for ketone enolate C‐acylation is described which utilizes alkyl pentafluorophenylcarbonates, ‐thiocarbonates, and ‐thionocarbonates as reactive acylating agents.
ChemInform Abstract: Bidentate Hydroxyalkyl NHC Ligands for the Copper‐Catalyzed Asymmetric Allylic Substitution of Allyl Phosphates with Grignard Reagents.
Authors: Magrez Magaly , Le Guen Yann , Basle Olivier , Crevisy Christophe , Mauduit Marc 
Published: May 2013

AbstractThe reaction proceeds with high regio‐ and enantioselectivity.
ChemInform Abstract: Metal‐Free Synthesis of Secondary Arylamines: An Aliphatic‐to‐Aromatic Transformation.
Authors: Barros M. Teresa , Dey Suvendu S. , Maycock Christopher D. 
Published: May 2013

AbstractThis is a facile method for the synthesis of diaryl‐ and monoarylamines from simple, inexpensive starting materials.
ChemInform Abstract: Synthesis of Ar‐BINMOL Ligands by [1,2]‐Wittig Rearrangement to Probe Their Catalytic Activity in 1,2‐Addition Reactions of Aldehydes with Grignard Reagents.
Authors: Zheng Long‐Sheng , Jiang Ke‐Zhi , Deng Yuan , Bai Xing‐Feng , Gao Guang , Gu Feng‐Lei , Xu Li‐Wen 
Published: May 2013

AbstractThis publication also contains the syntheses of several Ar‐BINMOL ligands including the one applied in the presented asymmetric Grignard reactions.
ChemInform Abstract: β‐Amination of Saturated Nitriles Through Palladium‐Catalyzed Dehydrogenation, 1,4‐Addition, and Re‐dehydrogenation.
Authors: Ueno Satoshi , Maeda Ryohei , Yasuoka Shohei , Kuwano Ryoichi 
Published: May 2013

AbstractAmination at the β‐position of 2‐arylpropionitriles (I) through catalytic dehydrogenation occurs in the presence of a Pd‐catalyst and bromobenzene.
ChemInform Abstract: Highly Efficient Synthesis of 3a,6a‐Dihydrofuro[2,3‐b]furans via a Novel Bicyclization.
Authors: Shu Wen‐Ming , Yang Yan , Zhang Dong‐Xue , Wu Liu‐Ming , Zhu Yan‐Ping , Yin Guo‐Dong , Wu An‐Xin 
Published: May 2013

AbstractThis method is also applicable to a one‐pot sequence starting from methyl ketones.
ChemInform Abstract: Pd‐Catalyzed Tandem Chemoselective Synthesis of 2‐Arylbenzofurans Using Threefold Arylating Triarylbismuth Reagents.
Authors: Rao Maddali L. N. , Jadhav Deepak N. , Dasgupta Priyabrata 
Published: May 2013

AbstractThis one‐pot tandem process obviates the use of preformed 2‐halobenzofurans to give 2‐arylbenzofurans.
ChemInform Abstract: Catalytic Asymmetric Michael Addition/Cyclization of Isothiocyanato Oxindoles: Highly Efficient and Versatile Approach for the Synthesis of 3,2′‐Pyrrolidinyl Mono‐ and Bi‐spirooxindole Frameworks.
Authors: Cao Yi‐Ming , Shen Fang‐Fang , Zhang Fu‐Ting , Wang Rui 
Published: May 2013

AbstractThe presented new method provides an easy and highly efficient way to access not only enantioenriched 3,2′‐pyrrolidinyl spirooxindole frameworks but also bi‐spirooxindoles containing three contiguous stereocenters and two spiro‐quaternary centers.
ChemInform Abstract: Synthesis and Stereochemical Investigation of Highly Functionalized Novel Dispirobisoxindole Derivatives via [3 + 2] Cycloaddition Reaction in Ionic Liquid.
Authors: Dandia Anshu , Jian Anuj K. , Laxkar Ashok K. , Bhati Dharmendra S. 
Published: May 2013

AbstractThe use of an ionic liquid for this reaction avoids the need for other reagents, e.
ChemInform Abstract: PEG‐SO3H as a Catalyst in Aqueous Media: A Simple, Proficient and Green Approach for the Synthesis of Quinoline Derivatives.
Authors: Nasseri M. A. , Alavi S. A. , Zakerinasab B. 
Published: May 2013

AbstractPEG‐6000‐anchored sulfonic acid is used as catalyst for a Friedlaender synthesis under environmentally benign conditions.
ChemInform Abstract: Efficient Synthesis of Substituted 3‐Azabicyclo[3.1.0]hexan‐2‐ones from 2‐Iodocyclopropanecarboxamides Using a Copper‐Free Sonogashira Coupling.
Authors: de Carne‐Carnavalet Benoit , Archambeau Alexis , Meyer Christophe , Cossy Janine , Folleas Benoit , Brayer Jean‐Louis , Demoute Jean‐Pierre 
Published: May 2013

AbstractA remarkable efficient synthesis of the title compounds is achieved from readily available cis‐2‐iodocyclopropanecarboxamides and terminal aryl‐, heteroaryl‐alkynes or enynes.
ChemInform Abstract: Synthesis of 2‐(3‐Methyl‐2‐oxoquinoxalin‐1(2H)‐yl)acetamide‐Based Azetidinone Derivatives as Potent Antibacterial and Antifungal Agents.
Authors: Kumar Shiv , Kumar Nitin , Drabu Sushma , Minhaj Md. Akram 
Published: May 2013

AbstractA variety of new azetidinone derivatives (V) (12 examples) are synthesized and evaluated for their antimicrobial activities.