bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Diagnostic Efficacy and Biological Effects of microRNA-29b for Colon Cancer
Authors: Li Leping , Guo Ying , Chen Yuezhi , Wang Jinshen , Zhen Lei , Guo Xiaobo , Liu Jinglei , Jing Changqing 
Published: October 2015

Background: Colorectal cancer is one of the most common cancers worldwide in terms of both incidence and mortality. The associations of expressions of tissue and plasma miR-29b were not detected in this study. Methods: There are 400 healthy age- and gender-matched controls enrolled in this study in a rate of 1:2. The receiver operating characteristic curve analysis was undertaken using the expression level for miR-29b in the colorectal cancer specimens from patients with cancer and healthy controls to assess the diagnostic accuracy of both tissue and plasma miR-29b levels. Results: It was found that the expression of plasma miR-29b is associated with the tissue miR-29b. Advanced study showed that aberrant miR-29b expression in both cancer tissues and plasma is associated with the clinicopathological data of patients with colorectal cancer. Tissue miR-29b showed an AUC of 0.883, with a sensitivity of 81.6% and a specificity of 84.9%. However, the AUC for plasma miR-29b was 0.743, with a sensitivity of 61.4% and a specificity of 72.5%. The analyses of the biological effects of miR-29b for colorectal cancer showed that miR-29b could inhibit the cell viability and migration. Conclusion: In summary, our data suggest that both the tissue and the plasma miR-29b levels have some value as a diagnostic tool for colorectal cancer. Advanced biological effects were conducted to detect the potential effect on the cell viability and migration. Future investigations including larger patient populations and patients with early-stage colorectal cancer are needed to confirm the potential diagnostic value of miRNA-29b in colorectal cancer.
A comparison of the non-invasive ultrasonic cardiac output monitor (USCOM) with the oesophageal Doppler monitor during major abdominal surgery
Authors: Hodgson Luke E , Forni Lui G , Venn Richard , Samuels Theophilus L , Wakeling Howard G 
Published: October 2015

Background Perioperative interventions, targeted to increase global blood flow defined by explicit measured goals, reduce postoperative complications. Consequently, reliable non-invasive estimation of the cardiac output could have far-reaching benefit. Methods This study compared a non-invasive Doppler device – the ultrasonic cardiac output monitor (USCOM) – with the oesophageal Doppler monitor (ODM), on 25 patients during major abdominal surgery. Stroke volume was determined by USCOM (SVUSCOM) and ODM (SVODM) pre and post fluid challenges. Results A ≥ 10% change (Δ) SVUSCOM had a sensitivity of 94% and specificity of 88% to detect a ≥ 10% Δ SVODM; the area under the receiver operating curve was 0.94 (95% CI 0.90–0.99). Concordance was 98%, using an exclusion zone of <10% Δ SVODM. 135 measurements gave median SVUSCOM 80 ml (interquartile range 65–93 ml) and SVODM 86 ml (69–100 ml); mean bias was 5.9 ml (limits of agreement −20 to +30 ml) and percentage error 30%. Conclusions Following fluid challenges SVUSCOM showed good concordance and accurately discriminated a change ≥10% in SVODM.
Fluctuations of Hyperglycemia and Insulin Sensitivity Are Linked to Menstrual Cycle Phases in Women With T1D
Authors: Brown Sue A. , Jiang Boyi , McElwee-Malloy Molly , Wakeman Christian , Breton Marc D. 
Published: October 2015

Background: Factors influencing glycemic variability in type 1 diabetes (T1D) may play a significant role in the refinement of closed loop insulin administration. Phase of menstrual cycle is one such factor that has been inadequately investigated. We propose that unique individual patterns can be constructed and used as parameters of closed loop systems. Method: Women with T1D on continuous subcutaneous insulin infusion and continuous glucose monitoring were studied for 3 consecutive menstrual cycles. Ovulation prediction kits and labs were used to confirm phase of menstrual cycle. Glycemic risks were assessed using the low- and high blood glucose indices (LBGI and HBGI). Insulin sensitivity (SI) was estimated using a Kalman filtering method from meal and insulin data. Overall change significance for glycemic risks was assessed by repeated measures ANOVA, with specific phases emphasized using contrasts. Results: Ovulation was confirmed in 33/36 cycles studied in 12 subjects (age = 33.1 ± 7.0 years, BMI = 25.7 ± 2.9 kg/m2, A1c = 6.8 ± 0.7%). Risk for hyperglycemia changed significantly during the cycle ( P = .023), with HBGI increasing until early luteal phase and returning to initial levels thereafter. LBGI was steady in the follicular phase, decreasing thereafter but not significantly. SI was depressed during the luteal phase when compared to the early follicular phase ( P ≤ .05). Total daily insulin, carbohydrates, or calories did not show any significant fluctuations. Conclusions: Women with T1D have glycemic variability changes that are specific to the individual and are linked to phase of cycle. An increased risk of hyperglycemia was observed during periovulation and early luteal phases compared to the early follicular phase; these changes appear to be associated with decreased insulin sensitivity during the luteal phase.
Can We Find Signals of Inclusive Entrepreneurship in Small Businesses? Exploring the Motives of Small Businesses for Establish Linkages with Non-profit Organisations
Authors: Díaz-Ramírez Julia Helena 
Published: October 2015

This study explores the motives and interests of small businesses (SBs) to establish partnerships with non-profit organisations (NPOs) in a developing country. Social issues in small and medium-sized enterprises (SMEs) are a topic of considerable research interest, and in this paper I explore those interactions that link the entrepreneurial nature of the SB with the actions that address social–economic issues. These partnerships enable to the SB to connect its economic purpose with its social function. I argue that the SB acts as a ‘social entrepreneur’ through those interactions. A sample of Colombian SBs which have established interactions with NPOs in the food sector is examined using an exploratory inductive methodological approach based on case studies. Furthermore, the findings reveal that the establishment of these kinds of partnerships depends on a combination of SBs surrounding conditions, the stage of development of the SB and the motivations of the owner-manager (OM). Those combinations are associated with a variety of logics and interests that give some signs of social and inclusive entrepreneurial behaviour in the SBs.
Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo
Authors: Block Helena , Stadtmann Anika , Riad Daniel , Rossaint Jan , Sohlbach Charlotte , Germena Giulia , Wu Dianqing , Simon Scott I. , Ley Klaus , Zarbock Alexander 
Published: October 2015

Key PointsGnb isoforms are centrally involved in Rac1-dependent chemokine-induced LFA-1 activation. Plcβ2 and Plcβ3 function nonredundantly to produce inositol triphosphate with subsequent calcium flux leading to LFA-1 activation.
Plasma preparation to measure FDA‐approved protein markers by selected reaction monitoring
Authors: Kiseleva Olga I. , Romashova Yulia A. , Moskaleva Natalia E. , Petushkova Natalia A. , Teryaeva Nadezhda B. , Belyaev Artem Yu. , Lisitsa Andrey V. 
Published: October 2015

AbstractBackgroundThe development of commercially available panels for human blood plasma screening via selected reaction monitoring (SRM) offers reliable, cost‐efficient and highly‐standardized discovery and validation of protein biomarkers. However, protein detection by SRM can be hampered by interfering peptide fragment ions. To estimate the influence of interference on protein detection, we performed different types of sample preparation and implemented SRM measurements for well‐characterized protein targets approved by the US Food and Drug Administration.MethodsWe used the PlasmaDeepDive™ SRM assay from BiognoSYS AG for absolute quantification of 18 proteins in 19 samples of human plasma using three different protocols for sample preparation. SRM measurements were performed using iRT standards for retention time normalization and isotopically‐labeled reference peptides for absolute quantification. SpectroDive™ software was used for automated detection of reliable peak groups.ResultsFourteen targeted proteins were quantitatively measured in more than half of the samples. Depletion of highly‐abundant plasma proteins and peptide fraction clean‐up on centrifuge plates resulted in detection of all 18 targeted proteins in femtomolar to picomolar concentrations.ConclusionsIt was shown that commercially designed SRM kits are suitable for SRM detection of well‐established plasma/serum biomarkers.
The contribution of contraception, marriage and postpartum insusceptibility to fertility levels in Uganda: an application of the aggregate fertility model
Authors: Rutaremwa Gideon , Galande Johnstone , Nviiri Hellen Laetitia , Akiror Edith , Jhamba Tapiwa 
Published: October 2015

Abstract
Background
While recent studies have indicated that fertility has remained high in Uganda, no systematic attempt has been made to identify the factors responsible for this persistent trend and to quantify these factors. This paper uses the Uganda Demographic and Health Surveys (UDHS) of 2006 and 2011, to examine the contribution contraceptive use, marriage and postpartum infecundability on one hand and Total Fertility Rate (TFR) on the other.
We constructed a database using the Woman’s Questionnaire from the UDHS 2006 and 2011. We then apply Bongaarts aggregate fertility model procedures to derive estimates of total fertility rate for the different socioeconomic groups.

Results
The findings indicate that a woman’s contraceptive behavior; marriage status and postpartum infecundability (also referred to as postpartum insusceptibility due to postpartum amenorrhea, which is intended to measure the effects on fertility breastfeeding), are important predictors of fertility outcomes. The results also show that higher education levels and urban residence are consistently associated with lower fertility rates and are positively associated with contraceptive use. Other key predictors of fertility include: wealth status, and region of residence.

Conclusion
The country needs to scale-up target interventions that are aimed at uplifting the education status of women and improving their economic wellbeing, because such interventions have a positive impact on fertility reduction and on improving maternal and reproductive health outcomes.
Joining up land and marine seismic data: Case study from Procida and Ventotene Islands (Tyrrhenian Sea, Italy)
Authors: Di Fiore Vincenzo , Cavuoto Giuseppe , Punzo Michele , Tarallo Daniela , Pelosi Nicola , Giordano Laura , Alberico Ines , Marsella Ennio , Mazzola Salvatore 
Published: October 2015

The seismic refraction survey, routinely used to obtain information on subsurface geology, has a limited use in the foreshore zone. We have evaluated a nonstandard approach to acquire seismic data in the backshore-foreshore area, joining up land and marine seismic data. The innovative part was the acquisition of a continuous seismic profile that allowed the recording of high-resolution data in a transition zone (TZ) to establish an integrated approach for improving the land-marine seismic model in areas characterized by a complex near surface geology. To achieve this objective, two seismic tests were carried out along the beaches of the Tyrrhenian islands of Procida and Ventotene. We defined the P-wave [Formula: see text] and S-wave velocities [Formula: see text] with depth by integrating the tomography of the refracted first arrivals ([Formula: see text] velocities versus depth) with the inversion of the phase velocities dispersion curves extracted from the surface waves (1D [Formula: see text] velocities models). Working with both seismic methods allowed us to overcame the limitations of each approach and to compare and check the obtained results. The velocity models enabled resolution of the near-surface velocity variations and definition of refractors down to a maximum depth of 40 m below ground level. This has provided useful insights to map the 2D bedrock surface and to evaluate ground stiffness and dynamic behavior of soil. Our study, aiming to demonstrate the feasibility of high-resolution seismic surveys in the land-sea TZ, proved that the use of a marine streamer connected to land cable, was a powerful tool to define different subsoil structures to assist with future planning (coastal management) of these areas.
Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice
Authors: Ock Sangmi , Lee Wang Soo , Ahn Jihyun , Kim Hyun Min , Kang Hyun , Kim Ho-Shik , Jo Daewoong , Abel E. Dale , Lee Tae Jin , Kim Jaetaek 
Published: October 2015

Abstract
IGF-1 receptor (IGF-1R) signaling is implicated in cardiac hypertrophy and longevity. However, the role of IGF-1R in age-related cardiac remodeling is only partially understood. We therefore sought to determine whether the deletion of the IGF-1R in cardiomyocytes might delay the development of aging-associated myocardial pathologies by examining 2-year-old male cardiomyocyte-specific IGF-1R knockout (CIGF1RKO) mice. Aging was associated with the induction of IGF-1R expression in hearts. Cardiomyocytes hypertrophied with age in wild-type (WT) mice. In contrast, the cardiac hypertrophic response associated with aging was blunted in CIGF1RKO mice. Concomitantly, fibrosis was reduced in aged CIGF1RKO compared with aged WT hearts. Expression of proinflammatory cytokines such as IL-1α, IL-1β, IL-6, and receptor activator of nuclear factor-κB ligand was increased in aged WT hearts, but this increase was attenuated in aged CIGF1RKO hearts. Phosphorylation of Akt was increased in aged WT, but not in aged CIGF1RKO, hearts. In cultured cardiomyocytes, IGF-1 induced senescence as demonstrated by increased senescence-associated β-galactosidase staining, and a phosphoinositide 3-kinase inhibitor inhibited this effect. Furthermore, inhibition of phosphoinositide 3-kinase significantly prevented the increase in IL-1α, IL-1β, receptor activator of nuclear factor-κB ligand, and p21 protein expression by IGF-1. These data reveal an essential role for the IGF-1-IGF-1R-Akt pathway in mediating cardiomyocyte senescence.
Ζωγραφικές μαρτυρίες του 12ου αιώνα στην Ανατολική Μακεδονία
Authors: ΣΤΡΑΤΗ Αγγελική 
Published: October 2015

<p> </p> <p><span style="font-family: 'Times New Roman', serif;"><span style="font-size: small;">Εξετάζονται δείγματα τοιχογραφικών διακοσμήσεων του 12ου αιώνα στον χώρο της Ανατολικής Μακεδονίας που έχουν εντοπιστεί σε ανασκαφέντα ναό στο Δέλτα του ποταμού Στρυμόνα κοντά στην Αμφίπολη, στις σωζόμενες τοιχογραφίες του ναού του Αγίου Νικολάου στον Ελαιώνα Σερρών και σε ένα μεμονωμένο φυλλοφόρο σταυρό, σε Αγίασμα στην Παλαιά Μητρόπολη Σερρών. Η ζωγραφική αυτή, παρά τον αποσπασματικό χαρακτήρα της, ακολουθεί πιστά τα ποικίλα ρεύματα της υστεροκομνήνειας κυρίως φάσης του 12ου αι., δημιουργώντας και εκφράζοντας τη δική της ανεξάρτητη καλλιτεχνική πρόταση.</span></span></p>
Η κτιτορική τοιχογραφία στο περίστωο της Παντανάσσης Φιλιππιάδος
Authors: ΒΟΚΟΤΟΠΟΥΛΟΣ Παναγιώτης Λ. 
Published: October 2015

<p><span style="color: #000000;"><span style="font-family: 'Times New Roman', serif;"><span style="font-size: small;">Σπαράγματα τοιχογραφίας που βρέθηκαν στο δυτικό άκρο της νότιας στοάς του καθολικού της Μονής Παντανάσσης, βορείως της Φιλιππιάδος, ανασυνετέθησαν το 2005. Παριστάνεται ηγεμονικό ζεύγος που στέφει η Θεοτόκος και ευλογεί ο Χριστός. Λείψανα μόνο σώθηκαν από δύο πριγκηπόπουλα. Από τις αποσπασματικά σωζόμενες επιγραφές το ζεύγος ταυτίζεται με τον δεσπότη της Ηπείρου Νικηφόρο Α΄(1267-1286) και την σύζυγό του Άννα Κομνηνοδουκένη Παλαιολογίνα, στους οποίους πρέπει ν’ αποδοθεί η ανέγερση του περιστώου. Διάφορα στοιχεία οδηγούν στην απόδοση της τοιχογραφίας γύρω στο 1294.</span></span></span></p> <p> </p>
Leukocyte telomere length and hippocampus volume: a meta-analysis
Authors: Nilsonne Gustav , Tamm Sandra , Månsson Kristoffer N. T. , Åkerstedt Torbjörn , Lekander Mats 
Published: October 2015

Leukocyte telomere length has been shown to correlate to hippocampus volume, but effect estimates differ in magnitude and are not uniformly positive. This study aimed primarily to investigate the relationship between leukocyte telomere length and hippocampus gray matter volume by meta-analysis and secondarily to investigate possible effect moderators. Five studies were included with a total of 2107 participants, of which 1960 were contributed by one single influential study. A random-effects meta-analysis estimated the effect to r = 0.12 [95% CI -0.13, 0.37] in the presence of heterogeneity and a subjectively estimated moderate to high risk of bias. There was no evidence that apolipoprotein E (APOE) genotype was an effect moderator, nor that the ratio of leukocyte telomerase activity to telomere length was a better predictor than leukocyte telomere length for hippocampus volume. This meta-analysis, while not proving a positive relationship, also is not able to disprove the earlier finding of a positive correlation in the one large study included in analyses. We propose that a relationship between leukocyte telomere length and hippocamus volume may be mediated by transmigrating monocytes which differentiate into microglia in the brain parenchyma.
The Role of Exosomes in Breast Cancer
Authors: Lowry Michelle C , Gallagher William M , O'Driscoll Lorraine 
Published: October 2015

AbstractBACKGROUNDAlthough it has been long realized that eukaryotic cells release complex vesicular structures into their environment, only in recent years has it been established that these entities are not merely junk or debris, but that they are tailor-made specialized minimaps of their cell of origin and of both physiological and pathological relevance. These exosomes and microvesicles (ectosomes), collectively termed extracellular vesicles (EVs), are often defined and subgrouped first and foremost according to size and proposed origin (exosomes approximately 30–120 nm, endosomal origin; microvesicles 120–1000 nm, from the cell membrane). There is growing interest in elucidating the relevance and roles of EVs in cancer.CONTENTMuch of the pioneering work on EVs in cancer has focused on breast cancer, possibly because breast cancer is a leading cause of cancer-related deaths worldwide. This review provides an in-depth summary of such studies, supporting key roles for exosomes and other EVs in breast cancer cell invasion and metastasis, stem cell stimulation, apoptosis, immune system modulation, and anti–cancer drug resistance. Exosomes as diagnostic, prognostic, and/or predictive biomarkers and their potential use in the development of therapeutics are discussed.SUMMARYAlthough not fully elucidated, the involvement of exosomes in breast cancer development, progression, and resistance is becoming increasingly apparent from preclinical and clinical studies, with mounting interest in the potential exploitation of these vesicles for breast cancer biomarkers, as drug delivery systems, and in the development of future novel breast cancer therapies.
Cell-Free RNA Is a Reliable Fetoplacental Marker in Noninvasive Fetal Sex Determination
Authors: Mersy Elke , Faas Brigitte H W , Spierts Sabine , Houben Leonie M H , Macville Merryn V E , Frints Suzanna G M , Paulussen Aimee D C , Veltman Joris A 
Published: October 2015

AbstractBACKGROUNDNoninvasive genetic tests that use cell-free fetal DNA (cffDNA) are used increasingly in prenatal care. A low amount of cffDNA can have detrimental effects on the reliability of these tests. A marker to confirm the presence of fetal nucleic acids is therefore required that is universally applicable and easy to incorporate.METHODSWe developed a novel multiplex, single-tube, noninvasive fetal sex determination assay by combining amplification of AMELY cffDNA with one-step reverse transcription (RT)-PCR of trophoblast-derived cell-free RNA (cfRNA), which functions as a sex-independent fetoplacental marker. We tested plasma samples from 75 pregnant women in duplicate in a blinded fashion. The fetus was considered to be male in the case of a positive result for AMELY and cfRNA amplification in both RT-PCRs. The fetus was considered to be female in the case of negative AMELY and positive cfRNA result in both RT-PCRs. In other cases, the test was repeated. We compared the results with invasive prenatal testing and pregnancy outcomes.RESULTSThe AMELY cffDNA amplification and cfRNA result was unambiguous and identical in duplicate in 71 of 75 plasma samples (95%). Four samples (5%) required an extra replicate because of an absent fetoplacental marker. Thereafter, fetal sex was correctly determined in all 75 plasma samples.CONCLUSIONSAmplification of trophoblast-derived cfRNA is a reliable marker for the confirmation of the presence of fetoplacentally derived nucleic acids in noninvasive fetal sex determination.
A sketch of the universe – the visual influences of D’Arcy Thompson’s On Growth and Form
Authors: Jarron Matthew 
Published: October 2015

Abstract
D’Arcy Thompson’s groundbreaking book On Growth and Form (1917) pioneered the science of mathematical biology. Its literary qualities have been frequently commented upon but arguably more influential have been its illustrations, particularly the famous transformation diagrams. This article discusses the origins and context of these iconic images, exploring D’Arcy Thompson’s own artistic and scientific interests, the long development of his controversial theories and the other collaborators involved, including illustrators Doris MacKinnon and Helen Ogilvie. It explores the various influences that the images have had in science, geography and particularly in art. Many notable artists have been drawn to the images and visual analogies of D’Arcy Thompson’s work, and the article concludes by describing examples ranging from the early graphic work of Henry Moore to the illustrative exercises created by Richard Hamilton and Victor Pasmore for their pioneering Basic Design Course, and on to current artists including Lindsay Sekulowicz and Gemma Anderson.
Nutzung von Hochschulbibliotheken
Authors: Vogel Bernd 
Published: October 2015

Zusammenfassung
Eine empirische Studie des Hochschul-Informations-Systems (HIS) hat im Jahr 20131
Vogel, Bernd; Woisch, Andreas. Orte des Selbststudiums. Eine empirische Studie zur zeitlichen und räumlichen Organisation des Lernens von Studierenden. Hannover, 2013.
die zeitliche und räumliche Organisation des Selbststudiums von Studierenden untersucht. Im Ergebnis zeigt sich, dass rund zwei Drittel der Studierenden am liebsten zu Hause lernen, während ein Drittel das Selbststudium in der Hochschule vorzieht. Beim Selbststudium in der Hochschule lernen die Studierenden am häufigsten in der Bibliothek (Universitäten 4 Stunden / Woche; Fachhochschulen 1,7 Stunden / Woche). Insgesamt lässt sich auch eine starke Polarisierung der Studierenden aus den Daten herauslesen: Viele Studierende lernen wenig in der Hochschule, wenige Studierende lernen viel in der Hochschule und erzeugen den Hauptbedarf an Arbeitsplätzen. Aus dem zeitlichen Aufwand für das Selbststudium, den die Studierenden angegeben haben, werden Planungsempfehlungen für den Bedarf an Arbeitsplätzen für das Selbststudium in den Hochschulen und speziell in den Hochschulbibliotheken abgeleitet.