bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fast cardiac T1ρ,adiab mapping using slice‐selective adiabatic spin‐lock preparation pulses
Authors: Tyler Andrew , Kunze Karl , Neji Radhouene , Masci Pier Giorgio , Razavi Reza , Chiribiri Amedeo , Roujol Sébastien 
Published: August 2024

AbstractPurposeMyocardial T1ρ mapping techniques commonly acquire multiple images in one breathhold to calculate a single‐slice T1ρ map. Recently, non‐selective adiabatic pulses have been used for robust spin‐lock preparation (T1ρ,adiab). The objective of this study was to develop a fast multi‐slice myocardial T1ρ,adiab mapping approach.MethodsThe proposed‐sequence reduces the number of breathholds required for whole‐heart 2D T1ρ,adiab mapping by acquiring multiple interleaved slices in each breathhold using slice‐selective T1ρ,adiab preparation pulses. The proposed‐sequence was implemented with two interleaved slices per breathhold scan and was quantitatively evaluated in phantom experiments and 10 healthy‐volunteers against a single‐slice T1ρ,adiab mapping sequence. The sequence was demonstrated in two patients with myocardial scar.ResultsThe phantom experiments showed the proposed‐sequence had slice‐to‐slice variation of 1.62% ± 1.05% and precision of 4.51 ± 0.68 ms. The healthy volunteer cohort subject‐wise mean relaxation time was lower for the proposed‐sequence than the single‐slice sequence (137.7 ± 5.3 ms vs. 148.4 ± 8.3 ms, p < 0.001), and spatial‐standard‐deviation was better (18.7 ± 1.8 ms vs. 21.8 ± 3.4 ms, p < 0.018). The mean within‐subject, coefficient of variation was 5.93% ± 1.57% for the proposed‐sequence and 6.31% ± 1.92% for the single‐slice sequence (p = 0.35) and the effect of slice variation (0.81 ± 4.87 ms) was not significantly different to zero (p = 0.61). In both patient examples increased T1ρ,adiab (maximum American Heart Association‐segment mean = 174 and 197 ms) was measured within the myocardial scar.ConclusionThe proposed sequence provides a twofold acceleration for myocardial T1ρ,adiab mapping using a multi‐slice approach. It has no significant difference in within‐subject variability, and significantly better precision, compared to a 2D T1ρ,adiab mapping sequence based on non‐selective adiabatic spin‐lock preparations.
Using the RE‐AIM and TDF frameworks to evaluate the implementation of a standardized cognitive assessment protocol in outpatient rehabilitation
Authors: Tierney‐Hendricks Carla , Schliep Megan E. , Sun Minsi , Gochyyev Perman , Carter Christopher 
Published: August 2024

AbstractBackgroundImpairments in cognition significantly affect patient functioning and rehabilitation outcomes. Assessment is essential to identifying at‐risk individuals and guiding care plans.ObjectiveA cognitive assessment protocol was implemented in occupational therapy (OT) and speech‐language pathology (SLP) outpatient practice. Using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE‐AIM) framework and Theoretical Domains Framework (TDF), this study (1) measured the reach and adoption of the cognitive assessment protocol and (2) explored determinants and strategies that may affect adoption.DesignSequential mixed methods.SettingTwo outpatient rehabilitation clinics (A and B) within a health care network.ParticipantsMedical records from 220 adult patients with neurologic diagnosis and 15 OT and SLP clinicians.InterventionsCognitive assessment protocol.Main Outcome Measure(s)Reach of the assessment protocol across patient characteristics and adoption across clinical sites were measured quantitatively via retrospective electronic medical records review. Qualitative data on effectiveness and the implementation process were collected via clinician focus groups.ResultsProtocol adoption rates were 71% and 54% at clinics A and B, respectively. Site B OT was more likely to be noncompliant with protocol adoption compared to Site A, when controlling for patient characteristics, (81% vs. 16%, respectively; odds ratio = 11.4, 95% confidence interval [3.36–38.64], p ≤ .001). Patient age was a significant factor for protocol reach; older age was associated with noncompliance of the SLP protocol adoption, p < .05. Both sites employed implementation strategies targeting the provider level (eg, education/training); Site A additionally included organization‐level strategies (eg, leadership engagement). In the absence of organization‐level strategies, OT and SLP clinicians at Site B identified barriers related to leadership support, resources, and workflow.ConclusionsStandardized practice protocols are feasible to implement within the rehabilitation setting, though multilevel implementation strategies may be needed to promote adoption. Aligning practices with the needs, values and priorities of the organization, providers, and patients and families is imperative.
Birth Weight and Labor Market Outcomes: Findings From Tohoku Medical Megabank Data
Authors: Matsushima Midori , Obara Taku , Ishikuro Mami , Nakaya Naoki , Hozawa Atsushi , Kuriyama Shinichi 
Published: August 2024

ABSTRACTBackgroundEpidemiological and economic literature has revealed that low birth weight (LBW) is related to poor health conditions and a broader range of negative socio‐economic outcomes, including academic achievement, income levels, and working status. However, Japanese evidence for labor outcomes is particularly lacking, as is the question of whether the impact of LBW on adulthood worsens when disasters occur. We aimed to reveal the impact on LBW on labor outcomes during the disaster recovery phase.MethodsWe used a cross‐sectional data set of 4156 national health insurance holders, males aged 40–60 years, from the Miyagi and Iwate prefectures during the earthquake recovery phase. Employing a multinomial probit and logistic model, we estimated the impact of LBW on the employment status, changes in income, and the propensity to face a decline in income with a job change.ResultsThe very low birth weights (VLBWs) have a disadvantage in all labor market outcomes. Compared to the non‐LBWs, the VLBWs were 15.2% less likely to be full‐time/self‐employed and 17.1% more likely to be contingent/temporary/part‐time workers. Moreover, 32.9% are more likely to face a decline in income and approximately 3.7 times more likely to change jobs leading to income decline. The LBWs were likely to face a decline in income by 8.6% and 4.6%, respectively, but no other significant effects were found on other outcomes.ConclusionsThe effects were apparent for the VLBW, but not so much for the LBW. The effects became larger during the disaster recovery phase, even though the regional economies were boosted.
Developing a methodology for user‐oriented verification of polar low forecasts
Authors: Hallerstig Matilda , Køltzow Morten Ødegaard , Mayer Stephanie 
Published: August 2024

AbstractPolar lows exhibit features with very sharp weather contrasts. In weather forecasting, a small misplacement of areas with hazardously high wind speeds can have fatal impacts for people living in polar regions. Therefore, a novel application of spatial verification methods for objective metrics of size, shape, and location of areas with hazardous weather is tested. To separate the effect of errors in polar low location and direction of motion from errors relative to the polar low centre, surface wind fields from the limited‐area weather forecasting model Applications of Research to Operations at Mesoscale‐Arctic and Copernicus Climate Change Service Arctic Regional Reanalysis are centred at the polar low centre and rotated according to the direction of background flow surrounding the polar low. Then the possibilities of the features‐based verification methods SAL (structure, amplitude, location) and MODE (Method for Object‐based Diagnostic Evaluation) are explored using a test case from October 2019. The study demonstrates that the methodology can provide valuable information about forecast performance. MODE is a flexible method with metrics that focus on characteristics of individual objects and can be adapted to questions at hand. For example, a measure of storm eye size was added. SAL, on the other hand, provides effective summary metrics for the full domain and proved particularly useful for evaluation of the overall distribution of wind speed. To evaluate the number of correctly or incorrectly identified areas with harsh weather rather than their details about their shape, contingency scores are more suitable. Applied to a larger dataset, this methodology can assess performance as a function of forecast length, as well as geographical area, and the type of polar low. The methodology can also be applied to other types of low‐pressure systems, such as extratropical cyclones.
Dual PGPR-AMF Inoculation Offsets Salinity Stress Impact on the Fodder Halophyte Sulla carnosa by Concomitantly Modulating Plant ABA Content and Leaf Antioxidant Response
Authors: Hidri Rabaa , Metoui-Ben Mahmoud Ouissal , Debez Ahmed , Zorrig Walid , Abdelly Chedly , Zamarreño Angel María , García-Mina José María , Azcon Rosario , Aroca Ricardo 
Published: August 2024

AbstractSalt-tolerant microbes are known to mitigate various biotic and abiotic stresses in plants. However, the intimate mechanisms involved, as well as their effects on the production of signaling molecules associated with the host plant–microbe interaction remain largely unknown. The present work aimed to investigate the role and potential uses of arbuscular mycorrhizal fungi (AMF) Rhizophagus intraradices and/or halotolerant plant growth-promoting rhizobacteria (PGPR) Bacillus subtilis in improving plant growth, functional biochemical synthesis and signaling of endogenous abscisic acid during plant response to short- and long-term salt stress in the forage halophyte Sulla carnosa. Plant growth attributes and biochemical traits were determined at 2 different time intervals (45 and 60 d after transplanting time) when salinity was raised from 100 to 200 mM NaCl. S. carnosa showed significant reduction in dry biomass in response to NaCl stress at the second harvest (200 mM NaCl); however inoculating plants with B. subtilis alone or associated with R. intraradices offset salt impact. Leaf electrolyte leakage was significantly increased by salinity but was significantly reduced following dual microbial inoculation. The applied bacterial inoculants also mitigated oxidative stress as reflected by the higher activities of catalase (APX) and superoxide dismutase (SOD) antioxidant enzymes and reduced H2O2 level. Inoculation with B. subtilis and R. intraradices upregulated 9-cisepoxycarotenoid dioxygenase 1 (NCED1) and SOD genes expression in S. carnosa plants upon salinity treatment. Furthermore, dual AMF-PGPR -inoculated plants accumulated significantly higher levels of abscisic acid (ABA) in both leaves and roots than non-inoculated and single inoculated plants under salinity stress at both harvest times, thereby accounting for their higher salt tolerance of salt-challenged S. carnosa plants. As a whole, the use of halophytic plants associated with beneficial soil microorganisms could improve the effectiveness of biological methods for saline soil rehabilitation. At the mechanistic level, ABA might represent a key player in the attenuation of salt impact in inoculated plants.
Quantitative evaluation of striatal uptake ratios using an adaptive template registration method for 123I-ioflupane dopamine transporter SPECT
Authors: Mizumura Sunao , Tamamura Naoyuki , Ebina Junya , Watanabe Hikaru , Hori Masaaki 
Published: August 2024

Abstract
Introduction
123I-FP-CIT (123I-Ioflupane) SPECT shows strong accumulation in the striatum, but morphological standardization is challenging due to low accumulation outside the striatum, particularly in subjects with marked striatal decline. In this study, morphological standardization without MRI was achieved using the adaptive template registration (ATR) method to create a subject-specific optimized template with weighted images of normal-type and egg-shape-type templates. The accuracy of a quantitative method for calculating the ratio with nonspecific accumulation in the occipital lobe was evaluated by placing voxels-of-interest (VOI) on standardized images, particularly targeting the striatum.

Methods
The average images of eight subjects, demonstrating normal-type and egg-shape-type tracer accumulation in 123I-Ioflupane SPECT, were utilized as normal and disease templates, respectively. The study included 300 subjects that underwent both 123I-Ioflupane SPECT and MRI for the diagnosis of suspected Parkinson's disease or for exclusion diagnosis. Morphological standardization of SPECT images using structural MRI (MRI-based method) was considered the standard of truth (SOT). Three morphological standardizations without MRI were conducted. The first involved conventional morphological standardization using a normal template (fixed template method), the second employed the ATR method, with a weighted template, and the third used the split-ATR method, processing the left and right striatum separately to address asymmetrical accumulation. VOIs were set on the striatum, caudate, putamen as regions of specific accumulation, and on the occipital lobe as a reference region for nonspecific accumulation.

Results
Results showed significant and robust linearity in the striatal accumulation ratios for all templates when compared with the occipital lobe accumulation ratio when using the MRI-based method. Comparing intra-class correlations for different linearities, the ATR method and split-ATR method demonstrated higher linearity in the striatum, caudate, and putamen. The split-ATR method showed similar improvements, although more linearity than some of the ATR methods; the effectiveness of the Split-ATR method may vary by image quality, and further validation of its effectiveness in diverse asymmetric accumulation cases seemed warranted.

Conclusion
The use of optimized templates, such as the ATR and split-ATR methods, improved reproducibility in fully automated processing and demonstrated superior linearity compared to that of MRI-based method, in the ratio to the occipital lobe. The ATR method, which enables morphological standardization when using SPECT images only, proved highly reproducible for clinical quantitative analysis of striatal accumulation, facilitating its clinical use.
Natural and revolutionary tumor-specific T-cell therapy
Authors: Dai Zhi , Liu Xue-Meng , Zhao Yun-li , Zhao Li-Xing , Luo Xiao-Dong 
Published: August 2024

AbstractRecently the FDA conducted a risk investigation and labeled the Boxed Warning for all BCMA- and CD19-directed CAR-T cell therapy, so does it mean that the public must take risk of secondary cancer to receive cell therapy? Here, without lentivirus and professional antigen presenting cell application, a novel tumor-specific T-cell therapy was successfully developed only by co-culturing MHC+ cancer cells and Naïve-T cells under the CD28 co-stimulatory signals. These tumor-specific T-cells could be separated through cell size and abundantly produced from peripheral blood, and would spontaneously attack target cells that carrying the same tumor antigen while avoiding others in vitro test. Moreover, it markedly decreased 90% tumor nodules companying with greatly improving overall survival (76 days vs 30 days) after twice infusion back to mice. This work maximally avoided the risks of secondary cancer and non-specific killing, and might open a revolutionary beginning of natural tumor-specific T-cell therapy.
Graphical Abstract
Racial Discrimination, Religious Coping, and Cardiovascular Disease Risk Among African American Women and Men
Authors: Ashe Jason , Bentley-Edwards Keisha , Skipper Antonius , Cuevas Adolfo , Vieytes Christian Maino , Bah Kristie , Evans Michele K. , Zonderman Alan B. , Waldstein Shari R. 
Published: August 2024

Abstract
Objective
This cross-sectional study examined whether religious coping buffered the associations between racial discrimination and several modifiable cardiovascular disease (CVD) risk factors—systolic and diastolic blood pressure (BP), glycated hemoglobin (HbA1c), body mass index (BMI), and cholesterol—in a sample of African American women and men.

Methods
Participant data were taken from the Healthy Aging in Neighborhoods of Diversity Across the Life Span study (N = 815; 55.2% women; 30–64 years old). Racial discrimination and religious coping were self-reported. CVD risk factors were clinically assessed.

Results
In sex-stratified hierarchical regression analyses adjusted for age, socioeconomic status, and medication use, findings revealed several significant interactive associations and opposite effects by sex. Among men who experienced racial discrimination, religious coping was negatively related to systolic BP and HbA1c. However, in men reporting no prior discrimination, religious coping was positively related to most risk factors. Among women who had experienced racial discrimination, greater religious coping was associated with higher HbA1c and BMI. The lowest levels of CVD risk were observed among women who seldom used religious coping but experienced discrimination.

Conclusion
Religious coping might mitigate the effects of racial discrimination on CVD risk for African American men but not women. Additional work is needed to understand whether reinforcing these coping strategies only benefits those who have experienced discrimination. It is also possible that religion may not buffer the effects of other psychosocial stressors linked with elevated CVD risk.
Longitudinal Relations Between Cyber Dating Aggression and Cyberbullying in Adolescence
Authors: Stevens L. Taylor , Coleman Jasmine N. , Waasdorp Tracy E. , Mehari Krista R. 
Published: August 2024

AbstractVery little research has examined the longitudinal relations between cyber dating aggression and cyberbullying during adolescence, which is important for informing prevention and intervention. This study fills a gap in the literature by examining the longitudinal relations between cyberbullying and cyber dating aggression. Data were collected from 185 ninth-grade students in the southeastern United States who endorsed being in a dating relationship within the past 30 days and participated in two waves of surveys three months apart. The sample was 50.3% female, 91.1% Black, and the mean age was 14.32 years old (SD = 0.56). Cyberbullying uniquely predicted subsequent increases in cyber dating aggression. Similarly, cyber dating aggression predicted subsequent increases in cyberbullying. In-person aggression (peer-targeted and dating) did not predict their online counterparts (cyberbullying and cyber dating aggression). Overall, these results indicate that aggression perpetrated online may generalize from one relational context (i.e., peer relationship) to another relationship context (i.e., dating relationship), such that efforts targeted at preventing online aggression in both relationship contexts may be most effective in preventing future online aggression.
Microstructurally resolved electrochemical evolution of mechanical- and irradiation-induced damage in nuclear alloys
Authors: Chen Xin , Pozuelo Marta , Gussev Maxim , Chancey Matthew , Wang Yongqiang , Balonis Magdalena , Bauchy Mathieu , Sant Gaurav 
Published: August 2024

AbstractThere is a need for high-throughput, scale-relevant, and direct electrochemical analysis to understand the corrosion behavior and sensitivity of nuclear materials that are exposed to extreme (high pressure, temperature, and radiation exposure) environments. We demonstrate the multi-scale, multi-modal application of scanning electrochemical cell microscopy (SECCM) to electrochemically profile corrosion alterations in nuclear alloys in a microstructurally resolved manner. Particularly, we identify that both mechanically deformed and irradiated microstructures show reduced charge-transfer resistance that leads to accelerated oxidation. We highlight that the effects of mechanical deformation and irradiation are synergistic, and may in fact, superimpose each other, with implications including general-, galvanic-, and/or irradiation-activated stress-corrosion cracking. Taken together, we highlight the ability of non-destructive, electrochemical interrogations to ascertain how microstructural alterations result in changes in the corrosion tendency of a nuclear alloy: knowledge which has implications to rank, qualify and examine alloys for use in nuclear construction applications.
The role of pit lake thermal dynamics on the thermal performance of ground heat exchangers
Authors: Carcamo-Medel Mauricio , Narsilio Guillermo , Fuentes Raul 
Published: August 2024

AbstractThe addition of ground heat exchangers (GHEs) to a pit lake’s basin has the potential for abundant, clean and renewable geothermal energy extraction using shallow geothermal systems. Basin-embedded GHEs avoid direct interaction with mine water, which has been shown to impact efficiency and longevity in mine open-loop geothermal systems negatively. The now accelerated closure of open-pit coal mines presents itself as an opportunity to use this technology. However, no guidelines currently exist for designing or operating GHEs embedded in the sediment of water bodies. Furthermore, the two-way coupling between the complex annual thermal fluid dynamics that lakes are naturally subjected to and heat fluxes on the sediments and the GHE system has not been explored. In this study, we develop and validate finite element models to assess the relevance of lake thermal stratification in the performance of a geothermal system embedded in water bodies basins, e.g., on open-pit mine closures, under temperate residential thermal loads. The results show that the pit lake’s role as a thermal sink improves significantly when the lake’s thermal dynamics are accounted for, with an increase of up to 292% in the lake’s available energy budget. A minor variation in energy budget (~8%) was found whether the lake is modelled explicitly or simplified as a transient Dirichlet temperature boundary condition. This small difference vanishes if horizontal circulation along the lake is considered, highlighting the lake’s thermal energy potential. Finally, the impact on the GHE Coefficient of Performance (COP) is evaluated, with a maximum of ~15% difference among all cases.
The protective effect of vinpocetine against Estradiol-benzoate induced cervical hyperkeratosis in female rats via modulation of SIRT1/Nrf2, and NLRP3 inflammasome
Authors: Rofaeil Remon R. , Mohyeldin Reham H. , Sharata Ehab E. , Attya Mina Ezzat , Essawy Hany , Ibrahim Osama A. , Abdelzaher Walaa Yehia 
Published: August 2024

AbstractThe current study was assigned to determine the putative preventive role of vinpocetine (VIN) in cervical hyperkeratosis (CHK) in female rats. Estradiol Benzoate (EB) was utilized in a dose f (60 μg/100 g, i.m) three times/week for 4 weeks to induce cervical hyperkeratosis. VIN was administered alone in a dose of (10 mg/kg/day, orally) for 4 weeks and in the presence of EB. Levels of malondialdehyde (MDA), total nitrites (NOx), reduced glutathione (GSH), interleukin-18 (IL-18), IL-1β, tumor necrosis factor-alpha (TNF-α) were measured in cervical tissue. The expression of NLRP3/GSDMD/Caspase-1, and SIRT1/Nrf2 was determined using ELISA. Cervical histopathological examination was also done. EB significantly raised MDA, NOx, TNF-α, IL-18, IL-1β, and GSDMD and up-regulated NLRP3/Caspase-1 proteins. However, GSH, SIRT1, and Nrf2 levels were reduced in cervical tissue. VIN significantly alleviates all biochemical and histopathological abnormalities. VIN considerably mitigates EB-induced cervical hyperkeratosis via NLRP3-induced pyroptosis and SIRT1/Nrf2 signaling pathway.