bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associated Inflammation or Increased Flow‐Mediated Shear Stress, but not Pressure Alone, Disrupts Endothelial Caveolin‐1 in Infants with Pulmonary Hypertension
Authors: Dereddy Narendra , Huang Jing , Erb Markus , Guzel Sibel , Wolk John H , Sett Suvro S , Gewitz Michael H , Mathew Rajamma 
Published: December 2012

Endothelial caveolin‐1 loss is an important feature of pulmonary hypertension (PH); the rescue of caveolin‐1 abrogates experimental PH. Recent studies in human PH suggest that the endothelial caveolin‐1 loss is followed by an enhanced expression of caveolin‐1 in smooth muscle cells (SMC) with subsequent neointima formation. In order to evaluate caveolin‐1 expression in infants with PH, we examined the available clinical histories, hemodynamic data, and the expression of caveolin‐1, PECAM‐1, vWF, and smooth muscle α‐actin in the lung biopsy/autopsy specimens obtained from infants with congenital heart disease (CHD, n = 8) and lung disease (n = 9). In CHD group, PH associated with increased pulmonary blood flow exhibited loss of endothelial caveolin‐1 and PECAM‐1 in pulmonary arteries; additional vWF loss was associated with enhanced expression of caveolin‐1 in SMC. In the absence of PH, increased or decreased pulmonary blood flow did not disrupt endothelial caveolin‐1, PECAM‐1, or vWF; nor was there any enhanced expression of caveolin‐1 in SMC. In Lung Disease + PH group, caveolin‐1, PECAM‐1, and vWF were well preserved in seven infants, and importantly, SMC in these arteries did not exhibit enhanced caveolin‐1 expression. Two infants with associated inflammatory disease exhibited loss of endothelial caveolin‐1 and PECAM‐1; additional loss of vWF was accompanied by enhanced expression of caveolin‐1 in SMC. Thus, associated flow‐induced shear stress or inflammation, but not elevated pulmonary artery pressure alone, disrupts endothelial caveolin‐1. Subsequent vWF loss, indicative of extensive endothelial damage is associated with enhanced expression of caveolin‐1 in SMC, which may worsen the disease.
Endothelin‐1 as a Mediator and Potential Biomarker for Interferon Induced Pulmonary Toxicity
Authors: George Peter M. , Cunningham Morven E. , Galloway‐Phillipps Neil , Badiger Rekha , Alazawi William , Foster Graham R. , Mitchell Jane A. 
Published: December 2012

Endothelin‐1 is a potent vasoconstrictor and a therapeutic target in pulmonary arterial hypertension. Endothelial cells are the physiological source of endothelin‐1 but in vitro data from our group shows that interferons (IFNα, IFNβ or IFNγ) induce endothelin‐1 in pulmonary vascular smooth muscle cells. IFNs are integral to innate immunity and their antiviral and immunomodulatory capability has been harnessed therapeutically; for example, IFNα plays a critical role in the treatment of chronic hepatitis C infection. However, in some patients, IFN causes pneumonitis and possibly irreversible pulmonary arterial hypertension. In this study, we found that of 16 patients undergoing a six‐month course of IFNα therapy, two demonstrated considerably increased serum levels of endothelin‐1. We propose that IFN therapy results in elevated levels of endothelin‐1 in some patients and when clinically significant levels are reached, pulmonary side effects could ensue. This hypothesis can be easily tested in IFN‐treated patients by measuring serum endothelin‐1 levels and cardiopulmonary physiological parameters.
Impact of Biofilms on Quality of Life of Rhinosinusitis Patients after Endoscopic Sinus Surgery
Authors: Gupta Neelima , Singh PP , Vaid Lakshmi , Arya Manish , Saha Rumpa 
Published: December 2012

ABSTRACT

Introduction
The chronic and recalcitrant nature of rhinosinusitis has been known from many years. Many reasons for this have been implicated and biofilms have now been established as one of the cause for its recurrent and persistent nature. Little literature and studies exist confirming this effect. This study presents analysis of sinonasal mucosal samples and correlates presence of biofilms with surgical outcomes.

Materials and methods
An analysis of mucosal samples collected during endoscopic sinus surgery from 40 patients of chronic rhinosinusitis (CRS) was done. Preoperative symptoms, endoscopic and radiological scores were documented and mucosal samples collected intraoperatively were sent for biofilm detection. Biofilm detection was performed using microtiter plate method. Postoperatively patients were followed up for minimum of 3 months with endoscopic evaluation and presence of ongoing symptoms was also recorded.

Results
Thirteen patients out of 40 patients showed positive bacterial culture. Eight out of 13, i.e. 61.53% bacteria produced biofilms and five out of 13, i.e. 38.46% bacteria did not produce biofilms. Patients with biofilms had significantly worse preoperative and postoperative symptom and endoscopic scores. Thus, presence of biofilms was related to poor outcomes.

Conclusion
This study showed that the presence of biofilms was correlated with higher symptom scores and poorer surgical outcomes. Also, more recurrences were found in patients with positive biofilms. This strengthens the belief that biofilms may play an active role in persisting mucosal inflammation and persistent symptoms in some patients of CRS. Treatment modalities aiming removal of biofilms may be important in management of CRS.

How to cite this article
Vaid L, Arya M, Gupta N, Singh PP, Saha R. Impact of Biofilms on Quality of Life of Rhinosinusitis Patients after Endoscopic Sinus Surgery. Clin Rhinol An Int J 2012;5(3):95-102.
Acute Dacryocystitis with Abscess: Endonasal Dacryocystorhinostomy, the Primary Treatment of Choice
Authors: Naik Sudhir , Naik Sarika S 
Published: December 2012

ABSTRACT

Background/objectives
Acute dacryocystitis, or inflammation of the lacrimal sac with abscess, is almost always secondary to nasolacrimal duct obstruction. The standard practice for treatment is incision and drainage because of concerns about the risks of exacerbation and spread of infection. Here, we tried to evaluate primary endoscopic dacryocystorhinostomy (EnDCR) as a treatment for acute dacryocystitis with abscess formation.

Materials and methods
This is comparative case series analysis study done during the study period of 54 months from January 2007 to May 2011. A total of 46 cases of acute dacryocystitis with lacrimal abscess managed were included in the study. Twenty-one cases were operated primarily with EnDCR. Rest of the 25 cases was managed conventionally by incision and drainage and later by an external DCR.

Results
Swelling disappeared intraoperatively in all EnDCR cases while medial canthal edema and erythema completely reduced within 2 to 3 days postoperatively. While in incision and drainage swelling disappeared partially intraoperatively and repeated draining was needed on the 2nd and 3rd day. The mean visual analog scale (VAS) score on first postoperative day was 3.14 in group A and was 4.64 in group B. Group A had faster pain relief with 95.23% improvement in epiphora while group B had slower pain relief but epiphora remained. Mean intraoperative blood was 65 ml in group A and minimal in group B.

Conclusion
Primary EnDCR is successful as a procedure of choice for acute dacryocystitis with abscess preventing further episodes of abscess formation and epiphora in the patients. We recommend EnDCR as the treatment of choice for acute dacryocystitis with lacrimal abscess.

How to cite this article
Naik SM, Naik SS. Acute Dacryocystitis with Abscess: Endonasal Dacryocystorhinostomy, the Primary Treatment of Choice. Clin Rhinol An Int J 2012;5(3):107-113.
Capillary Hemangioma of the Lateral Nasal Wall: An Unusual Location
Authors: Gupta Dharmendra Kumar , Somavanshi Samvartika , Bharti Rajni , Shree Neetu 
Published: December 2012

ABSTRACT
Capillary hemangioma also known as lobular capillary hemangioma (LCH) or pyogenic granuloma is a benign, vascular lesion of unknown origin, composed of blood vessels and are probably developmental rather than neoplastic in origin. They usually affect skin and mucous membranes of the oral cavity and rarely nasal mucosa. LCH bleeds on manipulations due to high vascularity. Microtraumas and hormonal imbalance are the major etiological factors in its development. Total excisional surgery is sufficient for treatment of the LCH. Capillary hemangioma arising from the nasal cavity is rarely encountered in our practice and rarely reported in the literature. We are reporting this case of LCH of lateral nasal wall because of its unusual location.

How to cite this article
Gupta DK, Somavanshi S, Agrawal A, Bharti R, Shree N. Capillary Hemangioma of the Lateral Nasal Wall: An Unusual Location. Clin Rhinol An Int J 2012;5(3): 127-129.
Bilateral Congenital Choanal Atresia in an 11-year-old Girl: An Unusual Presentation
Authors: Chandrashekharayya SH , Handi Prakash S , Riyas Mohammed 
Published: December 2012

ABSTRACT
Congenital choanal atresia (CCA) is characterized by narrowing of posterior nasal apertures in newborns present with nasal obstruction and respiratory difficulty. Although unilateral obstruction goes unnoticed at birth, bilateral case is an emergency situation because newborn is an obligate nasal breather. Here, we present an unusual case of bilateral choanal atresia in an 11-year-old girl, which is a rare finding. Surgical correction was done by transnasal approach using endoscopes and otological drill.

How to cite this article
Chandrashekharayya SH, Handi PS, Riyas M. Bilateral Congenital Choanal Atresia in an 11-year-old Girl: An Unusual Presentation. Clin Rhinol An Int J 2012;5(3):132-134.
Rhinocerebral Mucormycosis Presenting as Oroantral Fistula
Authors: Mane Rajashri Shailendra , Patil Balasaheb Chougonda , Mohite Anjana Avinash 
Published: December 2012

ABSTRACT
Mucormycosis refers to a severe infection with fungi of order Mucorales, seen in diabetic and immunocompromised patients. Rhino-orbito-cerebral mucormycosis is known to exist in two forms, the well-known acute form and the less well-recognized chronic form. The most common presenting features of the chronic form are ophthalmologic, including ptosis, proptosis, visual loss and ophthalmoplegia. Here, we report a case of chronic rhinocerebral mucormycosis (RCM) presented with nonhealing oroantral fistula in a diabetic patient without any orbital symptoms. We are reporting this case for its unusual presentation.

How to cite this article
Mane RS, Patil BC, Mohite AA. Rhinocerebral Mucormycosis Presenting as Oroantral Fistula. Clin Rhinol An Int J 2012;5(3):135-137.
Universidade e compromisso social: o impacto cultural, econômico e social promovido pela Faculdade Municipal de Palhoça
Authors: Silva Carolina , Pereira Fabio Henrique , Rodrigues Joici Lilian , Pereira Mariah Terezinha Nascimento , Medeiros Maristela Vieira 
Published: December 2012

Este artigo tem como objetivo identificar o impacto social, econômico e cultural que a Faculdade Municipal de Palhoça provoca no município. Para fundamentar o tema realizou-se a revisão de literatura com base em autores clássicos e contemporâneos contemplando o tema administração universitária. Foi desenvolvida uma pesquisa documental com base em documentos internos da FMP. Utilizou-se do método de pesquisa bibliográfica, exploratória e descritiva e analise qualitativa. Concluiu-se que o impacto social, econômico e cultural da Faculdade Municipal de Palhoça é notório, fundamentado nas características e vocação da instituição que atua diretamente na comunidade com projetos extensionistas, e um modelo de gestão empreendedora com foco em atender as necessidades do município, desenvolve seus projetos de cursos de graduação e pós graduação com foco no desenvolvimento local. A FMP faz parte da cidade de Palhoça.
Importancia de la responsabilidad social universitaria como desarrollo social de la Ciudad de Coronel Oviedo
Authors: Recalde Hugo Alfredo , Lusardi Willian Cantero , Jara Juan 
Published: December 2012

Dentro del marco de la responsabilidad social universitaria la UNC@, La Dirección de Investigación Científica realizo un “Estudio de Prevalencia de Parásitos Intestinales en Escolares de la Cuidad de Coronel Oviedo, se analizaron 638 muestras. Siendo los resultados: el 24% de los niños estaban parasitados, 45% de Áscaris lumbricoides, 35% de Giardia lamblia, 16% de Hymenolepis, 4% de Ansylotoma duodenale, de ello nace el proyecto un cambio en el barrio 1 de Marzo que consistió en talleres de capacitación en las áreas de las Ciencias Medicas, Ciencias Tecnológicas y Ciencias Económicas, dentro del campo de acción del conocimiento de cada Facultad. El trabajo se dividió en 2 etapas, la concienciación de la población estudiantil a través de charlas educativas impartidas por los becarios de la FCM, la segunda etapa en la realización del control antropométrico, administración de la dosis de antiparasitario y control de liendres de piojos con la entrega de los insumos para el tratamiento de los piojos. En esta actividad se invirtieron 56 horas distribuidas en 38 actividades, con una participación de aproximadamente 1.310 personas. De esta lógica de intervención se trabajo el componente de la transformación cultural de las personas al insertar en ellos las practicas de prevención y promoción de la salud, de esta manera la Universidad Nacional de Caaguazú cumple con la función integradora de la RSU
Explorer la mobilité internationale à travers le discours des grandes entreprises1
Authors: Point Sébastien , Dickmann Michael , Audouard Jean 
Published: December 2012

Cet article propose une analyse du discours officiel sur la mobilité internationale, à partir de 67 sites Internet de grands groupes français et allemands. Les messages demeurent très opérationnels, ne mentionnant que très rarement la carrière globale. Avant tout, le système de carrière national reste privilégié : si les groupes français proposent des messages élitistes, les messages allemands insistent sur la motivation des individus autour de l’acquisition de compétences dans une carrière de type fonctionnel. Cette étude propose également des pistes de réflexion permettant d’améliorer l’attractivité de l’entreprise envers les talents globaux, dans une stratégie de marque employeur.
Emergence d’une fonction d’innovation en PME : le rôle de l’intrapreneur1
Authors: Lerch Christophe , Schenk Eric , Cavallucci Denis 
Published: December 2012

Notre travail traite de l’émergence d’une fonction d’innovation (Le Massonet al., 2006) basée sur des activités de conception inventive au sein des PME. Notre attention se porte sur la démarche TRIZ (Altshuller, 1984), qui propose un certain nombre de concepts et outils qui permettent une approche systématique de la conception inventive.Comme le souligne Boldrini (2008, 2010), les PME peuvent bénéficier d’une aide extérieure pour la mise en oeuvre d’une telle fonction. Notre travail exploratoire repose sur l’étude de deux cas de PME innovantes, qui mettent en évidence le rôle de l’intrapreneur pour la mise en oeuvre d’innovations organisationnelles (Daft et Becker, 1978; Hage, 1999; Carrier, 1994, 1996, 1997) dans les PME.
Synthesis of Building Blocks and Oligonucleotides with {T}N3‐Alkylene‐N3{T} Cross‐Links
Authors: Sun Gang , Noronha Anne M. , Miller Paul S. , Wilds Christopher J. 
Published: December 2012

AbstractThis unit describes two methods to directly prepare oligonucleotide duplexes containing an N3thymidine‐alkylene‐N3thymidine inter‐strand cross‐link. The inter‐strand cross‐link can be engineered into the duplex with a number of possible orientations. Both methods require the preparation of a protected thymidine dimer where the N3 atoms of the two nucleosides are covalently attached by an alkyl linker. This linker is prepared starting from a protected diol using two successive alkylation reactions under basic conditions to accomplish the alkylation selectively at the N3 atom of the nucleoside. The chain length of the cross‐link can be varied based on the selection of the diol used in the dimer synthesis. The solid‐phase mono‐phosphoramidite approach involves oligonucleotide synthesis with 3′‐O‐phosphoramidites, on‐column removal of a 3′‐O‐tert‐butyldimethylsilyl protecting group, and continued oligonucleotide synthesis with 5′‐O‐phosphoramidites. The bis‐phosphoramidite approach does not require synthesis with 5′‐O‐phosphoramidites. At the end of synthesis using either method, the N3thymidine‐alkylene‐N3thymidine inter‐strand cross‐linked oligonucleotides can be removed from the solid‐support and purified using standard techniques (ion‐exchange HPLC) in yields sufficient for various structural studies and repair assays. Curr. Protoc. Nucleic Acid Chem. 51:5.11.1‐5.11.17. © 2012 by John Wiley & Sons, Inc.
Gene Editing in One‐Cell Embryos by Zinc‐Finger and TAL Nucleases
Authors: Wefers Benedikt , Meyer Melanie , Hensler Svenja , Panda Sudeepta , Ortiz Oskar , Wurst Wolfgang , Kühn Ralf 
Published: December 2012

AbstractGene targeting by sequence‐specific nucleases in one‐cell embryos provides an expedited mutagenesis approach in rodents. This technology has been recently established to create knockout and knockin mutants through sequence deletion or sequence insertion. This article provides protocols for the preparation and microinjection of nuclease mRNA and targeting vector DNA into fertilized mouse eggs. Furthermore, we provide guidelines for genotyping the desired mouse mutants. Curr. Protoc. Mouse Biol. 2:347‐364 © 2012 by John Wiley & Sons, Inc.
Short Introduction to Atomic and Molecular Configuration
Authors: Bender Dirk , González Leticia , Gräfe Stefanie 
Published: December 2012

Abstract
The sections in this article are

Introduction

Basics of Quantum Mechanics

Wavefunctions and Operators

Particle in a Box

Harmonic Oscillator – Vibrations

Particle on a Sphere, Rigid Rotor – Rotations

The Hydrogen Atom

Approximations

Variational Principle

Perturbation Theory

Born–
O
ppenheimer Approximation

Linear Combination of Atomic Orbitals

Solving the Electronic
S
chrödinger Equation

The Hartree–Fock Method

Basis Sets

Slater Versus
G
aussian Functions

Number of Basis Functions

Contracted Basis Sets

Electron Correlation

Configuration Interaction

Coupled Cluster Method

Multi‐Configurational Self‐Consistent Field Theory

M
øller–
P
lesset Perturbation Theory

Density Functional Theory

The Hohenberg–
K
ohn Theorems

The
K
ohn–
S
ham Approach

Advantages

Disadvantages

Time‐Dependent Density Functional Theory

Semiempirical Methods

Force Field Methods
Light Sources
Authors: Riesenberg Rainer , Wutting Andreas 
Published: December 2012

AbstractThe sections in this article areIntroductionBrief Review of Light PropertiesSpectrumRadiometric Properties and Beam Parameter ProductDiffuse SourcesNondiffuse SourcesCoherenceTemporal CoherenceSpatial CoherencePolarizationLight Generation and Light SourcesProcesses of Light GenerationGeneral Emission ProcessesLaser EmissionThermal SourcesTungsten Filament LampsHalogen LampsLow‐Pressure Gas Discharge LampsCold Cathode Fluorescent Lamps and Spectral LampsEnergy‐Saving LampsHollow‐Cathode LampsHydrogen and Deuterium LampsHigh‐Pressure Gas Discharge LampsShort Arc Lamps/High‐Intensity Discharge (HID) LampsOther High‐Pressure Gas Discharge LampsGas LasersLight–Emitting Diodes (LEDs)Laser DiodesOptically Pumped Semiconductor LasersOther Sources
Classical Microscopy
Authors: Roeser Kerstin , Zuehlke Dietlind , Gluch Martin , Grunst Gernoth , Sticker Markus , Bendrat Klaus , Niendorf Axel 
Published: December 2012

Abstract
The sections in this article are

Appearance

Application

Pathology

Materials

Methods (Tissue Processing)

Histological Staining

Microscopy

Diagnostics

Context‐Dependent Aspects in Morphological Diagnostics

Cognitive Aspects of Digital Microscopy
Raman Microscopy
Authors: Krafft Christoph , Popp Jürgen 
Published: December 2012

Abstract
Raman microscopy combines the power of label‐free and nondestructive vibrational spectroscopy with diffraction‐limited spatial resolution in the submicrometer range. Of particular interest is the application of Raman microscopy as an imaging modality. In the context of biophotonics, Raman microscopy has been used as a complementary tool in cytology and histopathology to assess cells and tissues. To improve the sensitive and specific detection of biomolecules with low scattering intensities or low abundance, signal‐enhancement techniques have been developed such as surface‐enhanced Raman scattering and resonance Raman scattering. This chapter describes recent biomedical examples.
Detection of Viral Infection in Epithelial Cells by Infrared Spectral Cytopathology
Authors: Diem Max , Laver Nora , Bedrossian Kristi , Schubert Jennifer , Papamarkakis Kostas , Bird Benjamin , Miljković Miloš 
Published: December 2012

Abstract
Recent results suggest that infrared microspectroscopy, coupled to methods of multivariate analysis, can distinguish normal from virally infected cells. This was established for infection of the oral cavity by the herpes simplex virus, which is associated with the outbreak of cold sores, and for infection of the cervix uteri by the human papillomavirus (HPV). In both cases, subtle (but different) spectral changes are observed that could be used for fast and inexpensive viral screening.
Organic Light‐Emitting Diodes (
OLEDs
): Next‐Generation Photodynamic Therapy of Skin Cancer
Authors: Samuel Ifor D.W. , Ferguson James , McNeill Andrew 
Published: December 2012

Abstract
The sections in this article are

Introduction

PDT
of Skin Cancer: Current Approach

Advances in Light Sources: Organic Light‐Emitting Diodes

Transforming
PDT
with Wearable Light Sources

Developing
OLEDs
for
PDT

Testing
OLEDs
for
PDT

Ambulatory
PDT
: a New Paradigm

Commercialization of Ambulatory
PDT

Conclusion
Intraoperative Optical Coherence Tomographic Monitoring
Authors: Douplik Alexandre 
Published: December 2012

AbstractOptical coherence tomography (OCT) modalities are considered in this chapter as intraoperative tools assisting the surgeon in decision‐making processes, guiding surgery near sensitive structures such as vessels and nerves, and delineating normal and pathologic tissue. Basic principles and modalities of OCT are briefly provided without details as those can be found in other chapters. Advantages, limitations, artifacts, and reproducibility of OCT imaging are briefly reviewed, together with particular intraoperative applications.
Bronchoscopy
Authors: Freitag Lutz , Darwiche Kaid , Hüttenberger Dirk 
Published: December 2012

AbstractThe sections in this article areDiagnosticsCancer DetectionFilter‐Based Techniques for Tumor DetectionFluorescence Techniques, Drug Induced FluorescenceFluorescence Techniques, Auto‐FluorescenceCommercially Available SystemsRemaining ProblemsTherapyLasers in BronchologyThermal Laser ApplicationsPhotodynamic TherapyNew Techniques: Fluorescence Microimaging, Optical Coherence Tomography
Advanced Laser Endoscopy in Urology: Laser Prostate Vaporization, Laser Surgery, and Laser Removal of Renal Calculi
Authors: Sroka Ronald , Seitz Michael , Bader Markus 
Published: December 2012

Abstract
The sections in this article are

Introduction

High‐Power Diode Laser for
BPH
‐Treatment

Preclinical Investigations

Clinical Laser Application for
BPH

Summary

Laser Therapy for the Upper Urinary Tract Tumors

Laser Interventions

Complications

Laser‐Assisted Lithotripsy

Experience from Preclinical Investigations

Laser Lithotripsy from the Clinical Point of View

Conclusion
Barrett's Esophagus and Gastroesophageal Reflux Disease – Diagnosis and Therapy
Authors: Dunn Jason M. , Bown Steven G. , Lovat Laurence B. 
Published: December 2012

AbstractThe sections in this article areIntroductionDiagnosisSpectroscopyScattering (Reflectance) SpectroscopyRaman SpectroscopyAbsorption SpectroscopyFluorescence SpectroscopySummaryTherapyArgon Plasma CoagulationPhotodynamic TherapyPhotofrinLevulanFoscanRadiofrequency AblationClinical StudiesAdverse EventsSubsquamous Specialized Intestinal MetaplasiaSSIMConclusion