bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and characterization of a new adsorbent for biomolecule separation: intercalation and adsorption of clavulanic acid in layered double hydroxides
Authors: Forte Marcus Bruno Soares , Taviot‐Guého Christine , Leroux Fabrice , Rodrigues Maria Isabel , Maugeri Filho Francisco 
Published: June 2015

AbstractBACKGROUNDA new layered double hydroxide (LDH) material has been developed through a pioneering approach, with the goal of being an alternative adsorbent for the separation of biomolecules, such as clavulanic acid (CA).RESULTSZn2Cr‐CA hybrid LDH assemblies were prepared through a coprecipitation method to evaluate the affinity between the CA molecule and the interlayer sites. The resulting inorganic–organic ‘sandwich’ structure was characterized by a combination of techniques showing an expansion of the layered structure from 0.78 nm up to values of 2.30 nm upon CA intercalation. Isotherm studies were carried out to evaluate the adsorption capacity of LDH towards CA. The Freundlich adsorption model was found to fit the experimental data well, indicating a relatively large adsorption capacity for the adsorbent Zn2Cr‐NO3, as high as 73.63, 128.76, and 229.62 mg1‐nFLnFg−1 at 20, 30, and 35 °C, respectively.CONCLUSIONZn2Cr‐NO3 adsorption capacity was not influenced by the presence of amino acids, thus underlining that it is a LDH composition which may be a suitable alternative for the separation of CA. LDH micro‐particles were additionally encapsulated with calcium alginate gel (LDHME) and characterized for particle average diameter (dp = 171 µm), bulk density (ρbulk = 0.63 g cm−3), particle density (ρp = 2.2 g cm−3), particle porosity (ϵp = 0.71) and bed porosity (ϵB = 0.40). The application of LDHME in the separation of CA from complex mixtures, containing tyrosine and proline, was considered satisfactory based on purification factors of about 2.32 and degrees of purity higher than 99%. © 2015 Society of Chemical Industry
Hydatidosis of a Pregnant Woman of the 3rd Century bc, Greece
Authors: Antikas T. G. , Wynn‐Antikas L. K. 
Published: June 2015

AbstractAnalyses of cremains of three individuals from a 3rd‐century‐bc hydria revealed a calcified hydatid cyst among commingled bones of a man, woman and fetus. The free cyst likely belonged to the pregnant woman who may have died of hydatidosis, a disease known in Greece since the 5th century bc. Hydatid cyst finds are rare in the literature. This is the first cyst found with cremains and in Greece. Copyright © 2015 John Wiley & Sons, Ltd.
Learning ordinal data
Authors: Qiao Xingye 
Published: June 2015

Classification is an important topic in statistical learning. The goal of classification is to build a predictive model from the training dataset for the class label of an observation. It is commonly assumed that the class labels are unordered. However, in many real applications, there exists an intrinsic ordinal relation between the class labels. Examples of these include cancer patients grouped in early, mediocre, and terminal stages, customers grouped into low, middle, and high credit levels, and experimental subjects enriched with different amounts of bacterial. In this article, we focus on the classification problem for ordinal data and introduce the theoretical setup of the problem. We review both traditional and modern methods in learning ordinal data. In particular, we emphasize the trade‐off between model flexibility and interpretability. Lastly, we discuss some issues regarding ordinal data learning, including an appropriate loss function for this problem.WIREs Comput Stat2015, 7:341–346. doi: 10.1002/wics.1357This article is categorized under:Statistical Learning and Exploratory Methods of the Data Sciences > Clustering and ClassificationStatistical and Graphical Methods of Data Analysis > Multivariate Analysis
Post‐transcriptional regulation in corticogenesis: how RNA‐binding proteins help build the brain
Authors: Pilaz Louis‐Jan , Silver Debra L. 
Published: June 2015

The cerebral cortex, the brain structure responsible for our higher cognitive functions, is built during embryonic development in a process called corticogenesis. During corticogenesis, neural stem cells generate distinct populations of progenitors and excitatory neurons. These new neurons migrate radially in the cortex, eventually forming neuronal layers and establishing synaptic connections with other neurons both within and outside the cortex. Perturbations to corticogenesis can result in severe neurodevelopmental disorders, thus emphasizing the need to better understand molecular regulation of brain development. Recent studies in both model organisms and humans have collectively highlighted roles for post‐transcriptional regulation in virtually all steps of corticogenesis. Genomic approaches have revealed global RNA changes associated with spatial and temporal regulation of cortical development. Additionally, genetic studies have uncovered RNA‐binding proteins (RBPs) critical for cell proliferation, differentiation, and migration within the developing neocortex. Many of these same RBPs play causal roles in neurodevelopmental pathologies. In the developing neocortex, RBPs influence diverse steps of mRNA metabolism, including splicing, stability, translation, and localization. With the advent of new technologies, researchers have begun to uncover key transcripts regulated by these RBPs. Given the complexity of the developing mammalian cortex, a major challenge for the future will be to understand how dynamic RNA regulation occurs within heterogeneous cell populations, across space and time. In sum, post‐transcriptional regulation has emerged as a critical mechanism for driving corticogenesis and exciting direction of future research. WIREs RNA 2015, 6:501–515. doi: 10.1002/wrna.1289This article is categorized under:

RNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications
RNA Export and Localization > RNA Localization
RNA in Disease and Development > RNA in Development
A national survey of gynecologists on current practice patterns for management of abnormal uterine bleeding in South Korea
Authors: Lee Ji Young , Lee Dong‐Yun , Song Jae Yen , Lee Eun Sil , Jeong Kyungah , Choi DooSeok 
Published: June 2015

AbstractObjectiveTo evaluate practice patterns of gynecologists in the management of abnormal uterine bleeding (AUB) in South Korea.MethodsBetween February 24 and March 12, 2014, a cross‐sectional survey was performed through face‐to‐face interviews with 100 gynecologists selected through quota sampling reflecting regions and hospital types. Through the use of a questionnaire, the level of awareness and practice patterns regarding diagnosis and management of AUB were evaluated.ResultsAmong 100 respondents, 60 reported that they had not previously heard of the International Federation of Gynecology and Obstetrics (FIGO) classification system. The standardization of AUB terminology was reported to be necessary or very necessary by 70 respondents. Pelvic ultrasonography would be used for diagnosis by 99 physicians. The most common first‐line AUB treatment was combined oral contraceptives: 55 respondents would use them for heavy menstrual bleeding, 56 for intermenstrual bleeding, and 56 for polycystic ovary syndrome. Combined oral contraceptives were the preferred follow‐up medication: 30 would use them for heavy menstrual bleeding, 24 for intermenstrual bleeding, and 52 for polycystic ovary syndrome.ConclusionDespite implementation of the FIGO AUB classification system and guidelines, awareness and use among gynecologists in South Korea remains low.
Pluralism and the Fate of Perestroika: A Historical Reflection
Authors: Gunnell John 
Published: June 2015

Although a great deal has been written about the perestroika movement in turn-of-the century political science its actual place in the history of the discipline has been poorly understood by its founders, defenders, and critics. Perestroika can be best understood as a manifestation of the persistent crises of identity that have characterized the discipline of political science, and it cannot be explained apart from the manner in which it was reflection of issues that attended both the origins of the field and periods such as the 1920s and aftermath of the behavioral era. What has been particularly important in each case has been the impact on both American politics and political science of the ethic of pluralism, which has created significant difficulties for both the practical and epistemic relationship between the discipline and its subject matter. — John Gunnell.This essay is followed by responses from James Farr, Robert O. Keohane, David D. Laitin, Kristen Renwick Monroe, Anne Norton, and Sanford F. Schram. John Gunnell then offers a response to commentators.
Nitric oxide stress and activation of AMP-activated protein kinase impair β-cell sarcoendoplasmic reticulum calcium ATPase 2b activity and protein stability
Authors: Tong X , Kono T , Evans-Molina C 
Published: June 2015

AbstractThe sarcoendoplasmic reticulum Ca2+ ATPase 2b (SERCA2b) pump maintains a steep Ca2+ concentration gradient between the cytosol and ER lumen in the pancreatic β-cell, and the integrity of this gradient has a central role in regulated insulin production and secretion, maintenance of ER function and β-cell survival. We have previously demonstrated loss of β-cell SERCA2b expression under diabetic conditions. To define the mechanisms underlying this, INS-1 cells and rat islets were treated with the proinflammatory cytokine interleukin-1β (IL-1β) combined with or without cycloheximide or actinomycin D. IL-1β treatment led to increased inducible nitric oxide synthase (iNOS) gene and protein expression, which occurred concurrently with the activation of AMP-activated protein kinase (AMPK). IL-1β led to decreased SERCA2b mRNA and protein expression, whereas time-course experiments revealed a reduction in protein half-life with no change in mRNA stability. Moreover, SERCA2b protein but not mRNA levels were rescued by treatment with the NOS inhibitor l-NMMA (NG-monomethyl l-arginine), whereas the NO donor SNAP (S-nitroso-N-acetyl-d,l-penicillamine) and the AMPK activator AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) recapitulated the effects of IL-1β on SERCA2b protein stability. Similarly, IL-1β-induced reductions in SERCA2b expression were rescued by pharmacological inhibition of AMPK with compound C or by transduction of a dominant-negative form of AMPK, whereas β-cell death was prevented in parallel. Finally, to determine a functional relationship between NO and AMPK signaling and SERCA2b activity, fura-2/AM (fura-2-acetoxymethylester) Ca2+ imaging experiments were performed in INS-1 cells. Consistent with observed changes in SERCA2b expression, IL-1β, SNAP and AICAR increased cytosolic Ca2+ and decreased ER Ca2+ levels, suggesting congruent modulation of SERCA activity under these conditions. In aggregate, these results show that SERCA2b protein stability is decreased under inflammatory conditions through NO- and AMPK-dependent pathways and provide novel insight into pathways leading to altered β-cell calcium homeostasis and reduced β-cell survival in diabetes.
A novel ETFB mutation in a patient with glutaric aciduria type II
Authors: Sudo Yosuke , Sasaki Ayako , Wakabayashi Takashi , Numakura Chikahiko , Hayasaka Kiyoshi 
Published: June 2015

AbstractGlutaric aciduria type II (GAII) is a rare inborn error of metabolism clinically classified into a neonatal-onset form with congenital anomalies, a neonatal-onset form without congenital anomalies and a mild and/or late-onset form (MIM #231680). Here, we report on a GAII patient carrying a homozygous novel c.143_145delAGG (p.Glu48del) mutation in the ETFB gene, who presented with a neonatal-onset form with congenital anomalies and rapidly developed cardiomegaly after birth.
Role of redox centre in charge transport investigated by novel self-assembled conjugated polymer molecular junctions
Authors: Wang Zongrui , Dong Huanli , Li Tao , Hviid Rune , Zou Ye , Wei Zhongming , Fu Xiaolong , Wang Erjing , Zhen Yonggang , Nørgaard Kasper , Laursen Bo W. , Hu Wenping 
Published: June 2015

AbstractMolecular electronics describes a field that seeks to implement electronic components made of molecular building blocks. To date, few studies have used conjugated polymers in molecular junctions despite the fact that they potentially transport charge more efficiently than the extensively investigated small-molecular systems. Here we report a novel type of molecular tunnelling junction exploring the use of conjugated polymers, which are self-assembled into ultrathin films in a distinguishable ‘planar’ manner from the traditional vertically oriented small-molecule monolayers. Electrical measurements on the junctions reveal molecular-specific characteristics of the polymeric molecules in comparison with less conjugated small molecules. More significantly, we decorate redox-active functionality into polymeric backbones, demonstrating a key role of redox centre in the modulation of charge transport behaviour via energy level engineering and external stimuli, and implying the potential of employing tailor-made polymeric components as alternatives to small molecules for future molecular-scale electronics.
iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity
Authors: Xu Yan , Ding Ya-Xin , Ding Jun , Lei Ya-Hui , Wu Ling-Yun , Deng Nai-Yang 
Published: June 2015

AbstractLysine succinylation in protein is one type of post-translational modifications (PTMs). Succinylation is associated with some diseases and succinylated sites data just has been found in recent years in experiments. It is highly desired to develop computational methods to identify the candidate proteins and their sites. In view of this, a new predictor called iSuc-PseAAC was proposed by incorporating the peptide position-specific propensity into the general form of pseudo amino acid composition. The accuracy is 79.94%, sensitivity 51.07%, specificity 89.42% and MCC 0.431 in leave-one-out cross validation with support vector machine algorithm. It demonstrated by rigorous leave-one-out on stringent benchmark dataset that the new predictor is quite promising and may become a useful high throughput tool in this area. Meanwhile a user-friendly web-server for iSuc-PseAAC is accessible at http://app.aporc.org/iSuc-PseAAC/ . Users can easily obtain their desired results without the need to understand the complicated mathematical equations presented in this paper just for its integrity.
Epitaxial growth of InP to bury directly bonded thin active layer on SiO2 /Si substrate for fabricating distributed feedback lasers on silicon
Authors: Fujii Takuro , Sato Tomonari , Takeda Koji , Hasebe Koichi , Kakitsuka Takaaki , Matsuo Shinji 
Published: June 2015

The authors have developed a new heterogeneous‐integration method for fabricating semiconductor lasers with high modulation efficiency on Si substrates. The method employs the direct bonding of an InP‐based active layer to the SiO2 layer of a thermally oxidised Si substrate (SiO2 /Si substrate), followed by the epitaxial growth of InP to form a buried heterostructure (BH). By using the InP membrane, the authors realise epitaxial growth of an InP on the InP membrane directly bonded to Si without crystal quality degradation. Both a theoretical estimation and photoluminescence measurements revealed that the total laser thickness must be less than the critical thickness determined by the applied thermal strain. The authors confirmed that the crystal quality of the BH is comparable to that fabricated on an InP substrate when using a 250‐nm‐thick InP‐based membrane. A distributed feedback laser fabricated on a SiO2 /Si substrate exhibited continuous‐wave operation up to 100°C and was directly modulated by a 40 Gbit/s non‐return‐to‐zero signal with a bias current of 15 mA. These results indicate that epitaxial growth using a directly bonded InP‐based active layer on a SiO2 /Si substrate allows us to achieve lasers with high modulation efficiency and to use a large‐scale Si wafer as a fabrication platform, resulting in low‐cost fabrication.
Identification of peanut seed prolamins with an antifungal role by 2D-GE and drought treatment
Authors: Senakoon Waraluk , Nuchadomrong Suporn , Chiou Robin Y-Y , Senawong Gulsiri , Jogloy Sanun , Songsri Patcharin , Patanothai Aran 
Published: June 2015

Abstract
This work revealed peanut seed prolamins likely displaying a defensive role besides the known nitrogen storage. Drought stress and proteomic approaches were used in varieties of peanuts to explore the prolamin member in association with a test against Aspergillus flavus spore germination. The stress effect was showed by aerial biomass, leaf content of malondialdehyde, and seed contamination by A. flavus. Sodium dodecyl sulfate–polyacrylamide gel electrophoresis profiles were not informative for the antifungal polypeptides. From two-dimensional gel electrophoresis, the suspected polypeptides were those with pI 5.45–5.75 and sizes of 22.0–30.5 kDa specifically in Spanish-type peanuts. Regarding to the drought effect in most of these peanuts, the spot peak volume analysis deduced three novel prolamin-related antifungal polypeptides at pI 5.75–5.8 with 30.5, 27.5–28.5, and 22.0–22.5 kDa, which was confirmed after isoelectric purification at pH 5.60. The data could not yet conclude their correlation with resistance to drought and to seed infection by A. flavus.
Explicit examples of equivalence relations and II₁ factors with prescribed fundamental group and outer automorphism group
Authors: Deprez Steven 
Published: June 2015

In this paper we give a number of explicit constructions for II

1

_1

factors and II

1

_1

equivalence relations that have prescribed fundamental group and outer automorphism group. We construct factors and relations that have uncountable fundamental group different from

R

+

∗

\mathbb {R}_{+}^{\ast }

. In fact, given any II

1

_1

equivalence relation, we construct a II

1

_1

factor with the same fundamental group. Given any locally compact unimodular second countable group

G
G

, our construction gives a II

1

_1

equivalence relation

R

\mathcal {R}

whose outer automorphism group is

G
G

. The same construction does not give a II

1

_1

factor with

G
G

as outer automorphism group, but when

G
G

is a compact group or if

G
=

S
L

n

±

R

=
{
g
∈

G
L

n

R

∣
det
(
g
)
=
±
1
}

G=\mathrm {SL}^{\pm }_n\mathbb {R}=\{g\in \mathrm {GL}_n\mathbb {R}\mid \det (g)=\pm 1\}

, then we still find a type II

1

_1

factor whose outer automorphism group is

G
G

.
"Something Dreadful and Grand"
Authors: Watt Stephen 
Published: June 2015

Abstract
This book traces the often uncanny relationships between Irish- and Jewish-Americans, arguing for the centrality of these diasporic groups to the development of American popular music, fiction, and especially drama. The book reads such cultural forms as tenement fiction, Tin Pan Alley music, and melodrama as part of a larger “circum–North Atlantic” world in which texts and performers from Ireland, Europe, and America were involved in a continuous cultural exchange within which stereotypes and performances of Jewishness and Irishness took center stage. For this reason, such Irish writers as James Joyce, Bernard Shaw, and Sean O’Casey played pivotal roles in the development of modern American culture, particularly as they influenced and interacted with writers like Elmer Rice, Clifford Odets, Henry Roth, and many others. Such Irish-American writers as Eugene O’Neill were similarly influenced by their interactions with Jewish-American writers like Michael Gold and Edward Dahlberg. While focusing on the modern period, this project traces a genealogy of modern drama and fiction to the nineteenth-century stage in which Irish and Jewish melodrama—and the appearances of international stars in such roles as Shylock and Leah, the Forsaken—shaped the often contradictory and excessive dimensions of ethnicity that are both allo-Semitic and allo-Hibernian. It also explores the larger dimensions of an Irish-Jewish unconscious underlying cultural production in America. The closing chapter considers more recent representations of Irish-Jewish interactions by John Banville, Brendan Behan, Norman Mailer, and Harold Pinter; and examples from a newer immigrant literature bring this discussion into the present.
Aiming for Global Accounting Standards
Authors: Camfferman Kees , Zeff Stephen A. 
Published: June 2015

Abstract
This book provides a historical study of the International Accounting Standards Board (IASB) from 2001 to 2011. During this period, the IASB and its International Financial Reporting Standards (IFRSs) acquired a central position in the practice and regulation of financial reporting around the world. As a unique instance of a private-sector body setting standards with legal force in many jurisdictions, the IASB’s rise to prominence has been accompanied by vivid political debates about its governance and accountability. Similarly, the IASB’s often innovative attempts to change the face of financial reporting have made it the centre of numerous controversies. The book traces the history of the IASB from its foundation as successor to the International Accounting Standards Committee (IASC), and discusses its operation, changing membership and leadership, the development of its standards, and their reception in jurisdictions around the world. The book gives particular attention to the IASB’s relationships with the European Union, the United States, and Japan, as well as to the impact of the financial crisis on the IASB’s work.
Setting Up the IASB
Authors: Camfferman Kees , Zeff Stephen A. 
Published: June 2015

Abstract
This chapter discusses the appointment of the initial trustees of the IASC Foundation, including their chairman Paul Volcker, and the trustees’ decisions and activities to bring the new IASB into being. The most vital of these decisions were the selection of the first chairman of the IASB and the other initial Board members. Once appointed, the initial Board chairman, Sir David Tweedie, played an active role in setting up the IASB. Other aspects of the IASB’s initial organization covered in this chapter include the creation of a Standards Advisory Council (SAC) and an International Financial Reporting Interpretations Committee (IFRIC), the building of a technical staff, and the soliciting of a sufficient amount of voluntary contributions to fund the new organization.
The First Wave of Jurisdictional Adoptions of IFRSs
Authors: Camfferman Kees , Zeff Stephen A. 
Published: June 2015

Abstract
The announcement by the European Union in 2000 of the required use of IFRSs in the consolidated financial statements of European listed companies, beginning in 2005, marked a turning point in the acceptance of IFRSs. Following the European example, other jurisdictions, including Australia and New Zealand also announced a mandatory transition to IFRSs. Meanwhile, some jurisdictions that had already adopted a policy of convergence with International Accounting Standards in the 1990s, particularly Hong Kong and South Africa, decided to move towards full adoption of IFRSs. Yet, there was little evidence of enthusiasm for IFRSs in Japan. In the United States, Enron and other accounting scandals helped to spark an interest in IFRSs. In 2002 the IASB and the FASB announced their so-called Norwalk Agreement aimed at converging their standards.