bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Neutron Diffraction and Electrochemical Study of FeNb11O29/Li11FeNb11 O29 for Lithium Battery Anode Applications.
Authors: Pinus Ilya , Catti Michele , Ruffo Riccardo , Salamone Matteo M. , Mari Claudio M. 
Published: May 2014

AbstractLi11FeNb11O29 is prepared by lithiation of FeNb11O29 with BuLi in hexane (50 °C, 96 h).
ChemInform Abstract: The Direct Synthesis of Hydrogen Peroxide Using Platinum‐Promoted Gold—Palladium Catalysts.
Authors: Edwards Jennifer K. , Pritchard James , Lu Li , Piccinini Marco , Shaw Greg , Carley Albert F. , Morgan David J. , Kiely Christopher J. , Hutchings Graham J. 
Published: May 2014

AbstractThe addition of a small amount of Pt to a CeO2‐supported AuPd (weight ratio of 1:1) catalyst significantly enhances the activity in the direct synthesis of H2O2 (autoclave, 5% H2/CO2 and 25% O2/CO2, 4.0 MPa, 2 °C, 30 min) and decreases the non‐desired over‐hydrogenation and decomposition reactions.
ChemInform Abstract: Substrate Stereocontrol in the Intramolecular Organocatalyzed Tsuji—Trost Reaction: Enantioselective Synthesis of Allokainates.
Authors: Vulovic Bojan , Gruden‐Pavlovic Maja , Matovic Radomir , Saicic Radomir N. 
Published: May 2014

AbstractOrgano‐catalyzed Tsuji—Trost cyclization of enantiopure educts (I) allows for a stereoselective access to (t)‐allokainic acids (III).
ChemInform Abstract: Catalytic Conjugate Addition of Acyl Anion Equivalents Promoted by Fluorodesilylation.
Authors: Denmark Scott E. , Cullen Lindsey R. 
Published: May 2014

AbstractConjugate addition of acyl anion equivalents derived from 2‐silyl‐1,3‐dithianes to α,β‐unsaturated ketones and esters is achieved using readily available Bu4NF as catalyst.
ChemInform Abstract: 3,3′‐Diiodo‐BINOL‐Fused Maleimides as Chiral Hypervalent Iodine(III) Organocatalysts.
Authors: Brenet Simon , Berthiol Florian , Einhorn Jacques 
Published: May 2014

AbstractAn intermolecular asymmetric MCPBA promoted oxidation of aryl alkyl ketones at the α‐position by using the title catalyst is developed.
ChemInform Abstract: An Optimized Synthetic Route for the Preparation of the Versatile Chiral Building Block 1,4‐Di‐O‐benzylthreitol.
Authors: Meier Bettina , Kollroser Manfred , Presser Armin 
Published: May 2014

AbstractA universal and facile synthetic route for the preparation of enantiopure L‐ and D‐1,4‐di‐O‐benzylthreitols (IX) from easily accessible L‐ or D‐tartaric acid, resp., is described.
ChemInform Abstract: Tin(II) Chloride Mediated Coupling Reactions Between Alkynes and Aldehydes.
Authors: Masuyama Yoshiro , Takamura Wataru , Suzuki Noriyuki 
Published: May 2014

AbstractTin dichloride mediates the coupling reaction between alkynes and aldehydes as a Lewis acid in nitromethane to stereoselectively produce (E)‐α,β‐unsaturated ketones by a skeletal transformation in which one alkynic carbon atom changes into an oxo carbon atom accompanied by the cleavage of a C=O bond in the starting aldehydes.
ChemInform Abstract: A Method to Prepare Optically Active Acyclic α‐Benzyl Ketones by Thermodynamically Controlled Deracemization.
Authors: Kaku Hiroto , Imai Takahiro , Kondo Risa , Mamba Shiho , Watanabe Yu , Inai Makoto , Nishii Takeshi , Horikawa Mitsuyo , Tsunoda Tetsuto 
Published: May 2014

AbstractThe process is appreciably influenced by the water/methanol solvent ratio.
ChemInform Abstract: Copper‐Catalyzed Oxidative Three‐Component Synthesis of N,N′,N′′‐Trisubstituted Guanidines.
Authors: Li Jihui , Neuville Luc 
Published: May 2014

AbstractThe presence of an NH group in the cyanamide is necessary as the secondary N‐methyl‐N‐phenylcyanamide does not participate in the process.
ChemInform Abstract: Generally Applicable and Efficient Esterification of Aldehydes with Alcohols Catalyzed by Cyclopalladated Ferrocenylimine.
Authors: Ma Gaizhi , Leng Yuting , Qiao Huijie , Yang Fan , Wang Shiwei , Wu Yangjie 
Published: May 2014

AbstractThe reaction requires catalyst loadings of only 0.0625 mol%.
ChemInform Abstract: Synthesis of de novo Chiral γ‐Amino‐ynamides Using Lithiated Ynamides. Observation of a Unique 5‐endo‐dig Cyclization with an Inversion of S‐Center.
Authors: Hsung Richard P. , Wang Xiao‐Na , Fox Sierra K. , Qi Rui , Lv Ming‐Can 
Published: May 2014

AbstractThe structures of the products (IIIa) and (XIIIc) are confirmed by X‐ray analysis.
ChemInform Abstract: Copper‐Catalyzed Oxidative Decarboxylative Couplings of Sulfoximines and Aryl Propiolic Acids.
Authors: Priebbenow Daniel L. , Becker Peter , Bolm Carsten 
Published: May 2014

AbstractElectron‐rich aryl propiolic acids are not well tolerated affording the desired N‐alkynylated sulfoximes in less than 20% yield and the Glaser—Hay dimer instead.
ChemInform Abstract: Large yet Flexible N‐Heterocyclic Carbene Ligands for Palladium Catalysis.
Authors: Meiries Sebastien , Le Duc Gaetan , Chartoire Anthony , Collado Alba , Speck Klaus , Arachchige Kasun S. Athukorala , Slawin Alexandra M. Z. , Nolan Steven P. 
Published: May 2014

AbstractThe title catalysts can be synthesized in eight steps from inexpensive and readily available 2‐nitro‐m‐xylene.
ChemInform Abstract: Iron‐Catalyzed Cross‐Coupling of Unactivated Secondary Alkyl Thio Ethers and Sulfones with Aryl Grignard Reagents.
Authors: Denmark Scott E. , Cresswell Alexander J. 
Published: May 2014

AbstractThe cross‐coupling reaction of unactivated alkyl aryl thioethers with aryl Grignard compounds is realized with nitrogen as “directing group” [reaction of (VI)].
ChemInform Abstract: Sequential Asymmetric Catalysis in Michael—Michael—Michael—Aldol Reactions: Merging Organocatalysis with Photoredox Catalysis in a One‐Pot Enantioselective Synthesis of Highly Functionalized Decalines Bearing a Quaternary Carbon Stereocenter.
Authors: Hong Bor‐Cherng , Lin Cheng‐Wei , Liao Wei‐Kai , Lee Gene‐Hsiang 
Published: May 2014

AbstractReaction of bromoacrylate (I) with cinnamic aldehyde (II) in the presence of diphenylsilylprolinol is optimized to yield a dialdehyde (III) produced by double Michael reaction.
ChemInform Abstract: Nucleopalladation Triggering the Oxidative Heck Reaction: A General Strategy to Diverse β‐Indole Ketones.
Authors: Wang Qian , Huang Liangbin , Wu Xia , Jiang Huanfeng 
Published: May 2014

AbstractThe presented method gives an easy and efficient access to 2‐ and 3‐substituted indoles and shows a broad tolerance of functionalities.
ChemInform Abstract: Rhodium‐Catalyzed Tandem Annulation and [5 + 1] Cycloaddition: 3‐Hydroxy‐1,4‐enyne as the 5‐Carbon Component.
Authors: Li Xiaoxun , Song Wangze , Tang Weiping 
Published: May 2014

AbstractA variety of substituted carbazoles and dibenzofuran (XIV) are efficiently prepared via a Rh‐catalyzed tandem annulation/[5 + 1]‐cycloaddition sequence using 3‐hydroxy‐1,4‐enynes as a new 5‐carbon component in the cycloaddition step.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of 9H‐Pyrrolo[1,2‐a]indol‐9‐ones and the Isomeric Indeno[2,1‐b]pyrrol‐8‐ones.
Authors: Wang Shuyang , Yang Qinghua , Dong Jingjing , Li Changwei , Sun Li , Song Chuanjun , Chang Junbiao 
Published: May 2014

AbstractThe isomeric title compounds are synthesized from the same substrates by intramolecular Heck reactions using different Pd catalysts.
ChemInform Abstract: Environmentally Benign Lewis Acid Promoted [2 + 3] Dipolar Cycloaddition Reactions of Nitrile Imines with Alkenes in Water.
Authors: Dadiboyena Sureshbabu , Hamme Ashton T. II 
Published: May 2014

AbstractThe nitrile imines emerge in situ from the α‐hydrazonyl chlorides (I) and undergo the title cycloaddition.
ChemInform Abstract: C—C Bond Cleavage of Keto‐Aziridines; Synthesis of Oxazoles via Regio‐Controlled Ring Expansion.
Authors: Samimi Heshmat Allah , Entezami Soraya 
Published: May 2014

AbstractVarious 2,5‐diaryloxazoles (II) are prepared regioselectively from the trans‐aziridines.
ChemInform Abstract: Chiral Phosphoric Acid Catalyzed Enantioselective Desymmetrization of meso‐Epoxides by Thiols.
Authors: Wang Zhaobin , Law Wai Kit , Sun Jianwei 
Published: May 2014

AbstractA mild and efficient protocol for the enantioselective opening of several cyclic and acyclic epoxides with good to high enantioselectivities is presented.
ChemInform Abstract: 5‐Ethoxymethylidene‐4‐thioxo‐2‐thiazolidinone as Versatile Building Block for Novel Biorelevant Small Molecules with Thiopyrano[2,3‐d][1,3]thiazole Core.
Authors: Atamanyuk Dmytro , Zimenkovsky Borys , Atamanyuk Vasyl , Lesyk Roman 
Published: May 2014

AbstractA variety of novel thiopyranothiazole derivatives are synthesized via hetero‐Diels—Alder reactions using the title ethoxymethylidene‐thiazolidinone (I) as heterodiene building block.
ChemInform Abstract: Catalytic Aromatization of 1,4‐Dihydropyridines by Radical Cation Salt Prompted Aerobic Oxidation.
Authors: Jia Xiaodong , Yu Liangliang , Huo Congde , Wang Yaxin , Liu Jing , Wang Xicun 
Published: May 2014

AbstractThe described method is advantageous with regards to mild reaction conditions, good functional group tolerance, and high efficiency for the oxidative aromatization.
ChemInform Abstract: Modular Isoquinoline Synthesis Using Catalytic Enolate Arylation and in situ Functionalization.
Authors: Pilgrim Ben S. , Gatland Alice E. , McTernan Charlie T. , Procopiou Panayiotis A. , Donohoe Timothy J. 
Published: May 2014

AbstractA multistep synthesis of functionalized isoquinolines using Pd‐catalyzed reaction of compounds (I), (V), and (XI) with methyl ketones followed by quenching with a variety of electrophiles is developed.
ChemInform Abstract: Ruthenium Hydride/Broensted Acid‐Catalyzed Tandem Isomerization/N‐Acyliminium Cyclization Sequence for the Synthesis of Tetrahydro‐β‐carbolines.
Authors: Hansen Casper L. , Clausen Janie W. , Ohm Ragnhild G. , Ascic Erhad , Le Quement Sebastian T. , Tanner David , Nielsen Thomas E. 
Published: May 2014

AbstractThis new approach represents an attractive alternative to the classical Pictet—Spengler reaction.
ChemInform Abstract: Synthesis of Polyhydroxylated Quinolizidines and Azaspiro[4.5]decanes from D‐Xylose.
Authors: Malik Michal , Witkowski Grzegorz , Ceborska Magdalena , Jarosz Slawomir 
Published: May 2014

AbstractDepending on the conditions the reaction of key intermediate (II) with allyl magnesium bromide yields either mono‐allylated compound (IV) or bis‐allylated compound (V) as main product.
ChemInform Abstract: BODIPY Based ′Click on′ Fluorogenic Dyes: Application in Live Cell Imaging.
Authors: Chauhan Dinesh Pratapsinh , Saha Tanmoy , Lahiri Mayurika , Talukdar Pinaki 
Published: May 2014

AbstractCopper‐catalyzed cycloaddition of non‐fluorescent BODIPY azide affords fluorescent derivatives which display up to 532‐fold enhancement of fluorescence in the red region.
ChemInform Abstract: Total Synthesis of Cristatic Acid Based on Late‐Stage Decarboxylative Allylic Migration and Biomimetic Aromatization of a Diketo Dioxinone.
Authors: George Nicolas S. , Anderson Katie E. , Barrett Anthony G. M. 
Published: May 2014

AbstractThe total synthesis of the title compound (I) including 15 linear steps is achieved in 2.7% overall yield.
ChemInform Abstract: Acid Hydrazides, Potent Reagents for Synthesis of Oxygen‐, Nitrogen‐, and/or Sulfur‐Containing Heterocyclic Rings
Authors: Majumdar Poulomi , Pati Anita , Patra Manabendra , Behera Rajani Kanta , Behera Ajaya Kumar 
Published: May 2014

AbstractReview: 383 refs.
ChemInform Abstract: Strategies for the Consolidation of Biologically Mediated Events in the Conversion of Pre‐Treated Lignocellulose into Ethanol
Authors: Bhutto Abdul Waheed , Qureshi Khadija , Harijan Khanji , Zahedi Gholamreza , Bahadori Alireza 
Published: May 2014

AbstractReview: 141 refs.
Efficient multi‐hop wireless broadcast protocol in vehicular networks using automated threshold function design
Authors: Slavik Michael , Mahgoub Imad , Alwakeel Mohammed 
Published: May 2014

SummaryVehicular networking applications often use multi‐hop wireless broadcasting as a primary data dissemination mechanism. Therefore, protocols that efficiently and thoroughly propagate application data while adapting to a wide range of network density, vehicle distribution pattern, channel quality, and other conditions are critical for vehicular communications. Here, we design the Statistical Vehicular Broadcast (SVB) protocol to efficiently distribute data via multi‐hop broadcast in vehicular networks.First, we present an automated optimization technique for the design of threshold functions in statistical broadcasting methods. Next, we compare and analyze known statistical techniques, including different fundamental methods, assessment delay algorithms, and failsafe mechanisms. All combinations of these techniques are given threshold functions optimized using the proposed automated procedure then are evaluated in a wide range of simulations. High‐level statistical design principles and recommendations are established based on analysis of these results. Finally, we apply those principles to design SVB. It is evaluated in JiST/SWANS and is shown to achieve a high target reachability level while consuming less bandwidth than similar protocols across urban and highway vehicular networking scenarios.Copyright © 2014 John Wiley & Sons, Ltd.
Endocrine disruption effects of p,p′‐DDE on juvenile zebrafish
Authors: Monteiro Marta Sofia , Pavlaki Maria , Faustino Augusto , Rêma Alexandra , Franchi Mariana , Gediel Letícia , Loureiro Susana , Domingues Inês , Rendón von Osten Jaime , Mortágua Velho Maia Soares Amadeu 
Published: May 2014

AbstractThe persistent organic pollutant p,p′‐DDE, the major metabolite of the insecticide DDT, has displayed evidence of endocrine disruption through the inhibition of androgen binding to androgen receptors in different species. Although p,p′‐DDE was continuously detected in wild fish with abnormal gonad development such as intersex, little is known about its mode of action during gonad development in fish. To elucidate the potential endocrine effects of this pollutant in zebrafish (Danio rerio), juveniles (30 days post hatch) were exposed to p,p′‐DDE during the critical window of sexual differentiation. Fish were exposed to sublethal concentrations ranging from 0.01 to 20 µg l–1 over 14 days and were maintained in control water for an additional 4 months. As core endpoints, the vitellogenin (vtg) concentration was measured at the end of exposure, and sex ratio and the gonadosomatic index were assessed 4 months after the end of exposure. An increase in vtg production in whole body homogenate was observed in fish exposed to 0.2 and 2.0 µg l–1 p,p′‐DDE. No significant differences were displayed in morphological parameters such as the gonadosomatic index of males and females or sex ratio. However, exposed females presented histopathological changes that include the reduction of the number of mature oocytes, which might impair their successful reproduction. These results demonstrate the ability of p,p′‐DDE to cause endocrine disruption in zebrafish exposed during gonad differentiation of juvenile specimens. Furthermore, vtg induction by p,p′‐DDE in juvenile zebrafish arises as a predictive marker for adverse effects of this DDT metabolite on the ovarian function of female zebrafish. Copyright © 2014 John Wiley & Sons, Ltd.
Synergistic cytotoxicity and DNA strand breaks in cells and plasmid DNA exposed to uranyl acetate and ultraviolet radiation
Authors: Wilson Janice , Zuniga Mary C. , Yazzie Filbert , Stearns Diane M. 
Published: May 2014

AbstractDepleted uranium (DU) has a chemical toxicity that is independent of its radioactivity. The purpose of this study was to explore the photoactivation of uranyl ion by ultraviolet (UV) radiation as a chemical mechanism of uranium genotoxicity. The ability of UVB (302 nm) and UVA (368 nm) radiation to photoactivate uranyl ion to produce single strand breaks was measured in pBR322 plasmid DNA, and the presence of adducts and apurinic/apyrimidinic sites that could be converted to single strand breaks by heat and piperidine was analyzed. Results showed that DNA lesions in plasmid DNA exposed to UVB‐ or UVA‐activated DU were only slightly heat reactive, but were piperidine sensitive. The cytotoxicity of UVB‐activated uranyl ion was measured in repair‐proficient and repair‐deficient Chinese hamster ovary cells and human keratinocyte HaCaT cells. The cytotoxicity of co‐exposures of uranyl ion and UVB radiation was dependent on the order of exposure and was greater than co‐exposures of arsenite and UVB radiation. Uranyl ion and UVB radiation were synergistically cytotoxic in cells, and cells exposed to photoactivated DU required different DNA repair pathways than cells exposed to non‐photoactivated DU. This study contributes to our understanding of the DNA lesions formed by DU, as well as their repair. Results suggest that excitation of uranyl ion by UV radiation can provide a pathway for uranyl ion to be chemically genotoxic in populations with dermal exposures to uranium and UV radiation, which would make skin an overlooked target organ for uranium exposures. Copyright © 2014 John Wiley & Sons, Ltd.
Citrate‐based biphasic scaffolds for the repair of large segmental bone defects
Authors: Guo Ying , Tran Richard T. , Xie Denghui , Wang Yuchen , Nguyen Dianna Y. , Gerhard Ethan , Guo Jinshan , Tang Jiajun , Zhang Zhongming , Bai Xiaochun , Yang Jian 
Published: May 2014

AbstractAttempts to replicate native tissue architecture have led to the design of biomimetic scaffolds focused on improving functionality. In this study, biomimetic citrate‐based poly (octanediol citrate)‐click‐hydroxyapatite (POC‐Click‐HA) scaffolds were developed to simultaneously replicate the compositional and architectural properties of native bone tissue while providing immediate structural support for large segmental defects following implantation. Biphasic scaffolds were fabricated with 70% internal phase porosity and various external phase porosities (between 5 and 50%) to mimic the bimodal distribution of cancellous and cortical bone, respectively. Biphasic POC‐Click‐HA scaffolds displayed compressive strengths up to 37.45 ± 3.83 MPa, which could be controlled through the external phase porosity. The biphasic scaffolds were also evaluated in vivo for the repair of 10‐mm long segmental radial defects in rabbits and compared to scaffolds of uniform porosity as well as autologous bone grafts after 5, 10, and 15 weeks of implantation. The results showed that all POC‐Click‐HA scaffolds exhibited good biocompatibility and extensive osteointegration with host bone tissue. Biphasic scaffolds significantly enhanced new bone formation with higher bone densities in the initial stages after implantation. Biomechanical and histomorphometric analysis supported a similar outcome with biphasic scaffolds providing increased compression strength, interfacial bone ingrowth, and periosteal remodeling in early time points, but were comparable to all experimental groups after 15 weeks. These results confirm the ability of biphasic scaffold architectures to restore bone tissue and physiological functions in the early stages of recovery, and the potential of citrate‐based biomaterials in orthopedic applications. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 772–781, 2015.
Delivery of alginate‐chitosan hydrogel promotes endogenous repair and preserves cardiac function in rats with myocardial infarction
Authors: Deng Biyong , Shen Li , Wu Yizhe , Shen Yunli , Ding Xuefeng , Lu Shuyang , Jia Jianguo , Qian Juying , Ge Junbo 
Published: May 2014

AbstractThe regenerative potential of alginate‐chitosan composite in bone and cartilage tissue has been well documented, but its potential utility in cardiac tissue engineering has remained unknown. This study sought to determine whether early intramyocardial injection of alginate‐chitosan could prevent left ventricular (LV) remodeling after myocardial infarction (MI), leading to a more favorable course of tissue restoration. In a rat model of acute MI, local injection of alginate‐chitosan hydrogel into the peri‐infarct zone preserved scar thickness, attenuated infarct expansion, and reduced scar fibrosis after 8 weeks, concomitantly with promoting increased angiogenesis and greater recruitment of endogenous repair at the infarct zone. Furthermore, this treatment prevented cell apoptosis, induced cardiomyocyte cell cycle re‐entry. The cardiac function of the control‐injected animals deteriorated over the 8‐week course, while that of the hydrogel‐injected animals did not.In addition, the hydrogel did not exacerbate inflammation in the heart. Intramyocardial injection of alginate‐chitosan hydrogel represents a useful strategy to treat MI. It demonstrated marked therapeutic efficacies on various tissue levels after extensive MI, as well as potential to induce endogenous cardiomyocyte proliferation and recruit cardiac stem cells. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 907–918, 2015.
Lack of meaningful effect of ridaforolimus on the pharmacokinetics of midazolam in cancer patients: Model prediction and clinical confirmation
Authors: Stroh Mark , Talaty Jennifer , Sandhu Punam , McCrea Jacqueline , Patnaik Amita , Tolcher Anthony , Palcza John , Orford Keith , Breidinger Sheila , Narasimhan Narayana , Panebianco Deborah , Lush Richard , Papadopoulos Kyriakos P. , Wagner John A. , Trucksis Michele , Agrawal Nancy 
Published: May 2014

AbstractRidaforolimus, a unique non‐prodrug analog of rapamycin, is a potent inhibitor of mTOR under development for cancer treatment. In vitro data suggest ridaforolimus is a reversible and time‐dependent inhibitor of CYP3A. A model‐based evaluation suggested an increase in midazolam area under the curve (AUC0–∞) of between 1.13‐ and 1.25‐fold in the presence of therapeutic concentrations of ridaforolimus. The pharmacokinetic interaction between multiple oral doses of ridaforolimus and a single oral dose of midazolam was evaluated in an open‐label, fixed‐sequence study, in which cancer patients received a single oral dose of 2 mg midazolam followed by 5 consecutive daily single oral doses of 40 mg ridaforolimus with a single dose of 2 mg midazolam with the fifth ridaforolimus dose. Changes in midazolam exposure were minimal [geometric mean ratios and 90% confidence intervals: 1.23 (1.07, 1.40) for AUC0–∞ and 0.92 (0.82, 1.03) for maximum concentrations (Cmax), respectively]. Consistent with model predictions, ridaforolimus had no clinically important effect on midazolam pharmacokinetics and is not anticipated to be a perpetrator of drug–drug interactions (DDIs) when coadministered with CYP3A substrates. Model‐based approaches can provide reasonable estimates of DDI liability, potentially obviating the need to conduct dedicated DDI studies especially in challenging populations like cancer patients.
Consumer Intentions to Revisit Online Retailers: A Mental Imagery Account
Authors: Argyriou Evmorfia 
Published: May 2014

ABSTRACTThe current research explores the role of Web site characteristics, such as animation and iconic navigation aids, in predicting consumers’ self‐reported intentions to revisit a retailer's Web site. An experimental study (n= 339) shows that Web site characteristics do not affect revisit intentions directly but through the vividness of mental images that consumers hold of the Web site as a whole. Vivid mental Web site imagery is stimulated by animation and facilitated by individual tendencies to put faith in intuitive rather than rational thinking, while it does not relate to the use of icons in navigation. The implications of these findings for researchers, Web designers and marketers are discussed.