bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Toxicity and Quality of Life After Dose-Intensified Salvage Radiation Therapy for Biochemically Recurrent Prostate Cancer After Prostatectomy: First Results of the Randomized Trial SAKK 09/10
Authors: Ghadjar Pirus , Hayoz Stefanie , Bernhard Jürg , Zwahlen Daniel R. , Hölscher Tobias , Gut Philipp , Guckenberger Matthias , Hildebrandt Guido , Müller Arndt-Christian , Plasswilm Ludwig , Papachristofilou Alexandros , Stalder Lukas , Biaggi-Rudolf Christine , Sumila Marcin , Kranzbühler Helmut , Najafi Yousef , Ost Piet , Azinwi Ngwa C. , Reuter Christiane , Bodis Stephan , Kaouthar Khanfir , Wust Peter , Thalmann George N. , Aebersold Daniel M. 
Published: November 2015

Purpose Patients with biochemical failure (BF) after radical prostatectomy may benefit from dose-intensified salvage radiation therapy (SRT) of the prostate bed. We performed a randomized phase III trial assessing dose intensification. Patients and Methods Patients with BF but without evidence of macroscopic disease were randomly assigned to either 64 or 70 Gy. Three-dimensional conformal radiation therapy or intensity-modulated radiation therapy/rotational techniques were used. The primary end point was freedom from BF. Secondary end points were acute toxicity according to the National Cancer Institute Common Terminology Criteria for Adverse Events (version 4.0) and quality of life (QoL) according to the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaires C30 and PR25. Results Three hundred fifty patients were enrolled between February 2011 and April 2014. Three patients withdrew informed consent, and three patients were not eligible, resulting in 344 patients age 48 to 75 years in the safety population. Thirty patients (8.7%) had grade 2 and two patients (0.6%) had grade 3 genitourinary (GU) baseline symptoms. Acute grade 2 and 3 GU toxicity was observed in 22 patients (13.0%) and one patient (0.6%), respectively, with 64 Gy and in 29 patients (16.6%) and three patients (1.7%), respectively, with 70 Gy (P = .2). Baseline grade 2 GI toxicity was observed in one patient (0.6%). Acute grade 2 and 3 GI toxicity was observed in 27 patients (16.0%) and one patient (0.6%), respectively, with 64 Gy, and in 27 patients (15.4%) and four patients (2.3%), respectively, with 70 Gy (P = .8). Changes in early QoL were minor. Patients receiving 70 Gy reported a more pronounced and clinically relevant worsening in urinary symptoms (mean difference in change score between arms, 3.6; P = .02). Conclusion Dose-intensified SRT was associated with low rates of acute grade 2 and 3 GU and GI toxicity. The impact of dose-intensified SRT on QoL was minor, except for a significantly greater worsening in urinary symptoms.
The cytolinker plectin regulates nuclear mechanotransduction in keratinocytes
Authors: Almeida Filipe V. , Walko Gernot , McMillan James R. , McGrath John A. , Wiche Gerhard , Barber Asa H. , Connelly John T. 
Published: November 2015

ABSTRACT
The transmission of mechanical forces to the nucleus is important for intracellular positioning, mitosis and cell motility, yet the contribution of specific components of the cytoskeleton to nuclear mechanotransduction remains unclear. In this study, we examine how crosstalk between the cytolinker plectin and F-actin controls keratin network organisation and the 3D nuclear morphology of keratinocytes. Using micro-patterned surfaces to precisely manipulate cell shape, we find that cell adhesion and spreading regulate the size and shape of the nucleus. Disruption of the keratin cytoskeleton through loss of plectin facilitated greater nuclear deformation, which depended on acto-myosin contractility. Nuclear morphology did not depend on direct linkage of the keratin cytoskeleton with the nuclear membrane, rather loss of plectin reduced keratin filament density around the nucleus. We further demonstrate that keratinocytes have abnormal nuclear morphologies in the epidermis of plectin-deficient, epidermolysis bullosa simplex patients. Taken together, our data demonstrate that plectin is an essential regulator of nuclear morphology in vitro and in vivo and protects the nucleus from mechanical deformation.
Fascial Manipulation® for chronic aspecific low back pain: a single blinded randomized controlled trial
Authors: Branchini Mirco , Lopopolo Francesca , Andreoli Ernesto , Loreti Ivano , Marchand Aurélie M , Stecco Antonio 
Published: November 2015

Background: The therapeutic approach to chronic aspecific low back pain (CALBP) has to consider the multifactorial aetiology of the disorder. International guidelines do not agree on unequivocal treatment indications. Recommendations for fascial therapy are few and of low level evidence but several studies indicate strong correlations between fascial thickness and low back pain. This study aims at comparing the effectiveness of Fascial Manipulation® associated with a physiotherapy program following guidelines for CALBP compared to a physiotherapy program alone.Methods: 24 subjects were randomized into two groups, both received eight treatments over 4 weeks. Outcomes were measured at baseline, at the end of therapy and at a 1 month and a 3 months follow-up. Pain was measured with the visual analogue scale (VAS) and the brief pain inventory (BPI), function with the Rolland-Morris disability questionnaire (RMDQ), state of well-being with the short-form 36 health-survey (SF-36). The mean clinical important difference (MCID) was also measured.Results: Patients receiving Fascial Manipulation® showed statistically and clinically significant improvements at the end of care for all outcomes, in the short (RMDQ, VAS, BPI) and medium term for VAS and BPI compared to manual therapy. The MCID show significant improvements in the means and percentage of subjects in groups in all outcomes post-treatment, in the short and medium term.Conclusion: Fascial tissues were implicated in the aetiology of CALBP and treatment led to decreased symptomatic, improved functional and perceived well-being outcomes that were of greater amplitude compared to manual therapy alone.
Tasks and Functions of Audit of Materials and Supplies Inventories in Agricultural Organizations
Authors: Фазульянова  , Fazulyanova Zulfiya 
Published: November 2015

The article is devoted to tasks and functions of audit of materials and supplies inventories in agriculture which
include both a set of general tasks and functions of audit and special tasks and functions of audit of materials and
supplies inventories, as well as specifics of agricultural organizations.
Comparison of halocarbon measurements in an atmospheric dry whole air sample
Authors: Rhoderick George C. , Hall Bradley D. , Harth Christina M. , Kim Jin Seog , Lee Jeongsoon , Montzka Stephen A. , Mühle Jens , Reimann Stefan , Vollmer Martin K. , Weiss Ray F. 
Published: November 2015

Abstract
The growing awareness of climate change/global warming, and continuing concerns regarding stratospheric ozone depletion, will require continued measurements and standards for many compounds, in particular halocarbons that are linked to these issues. In order to track atmospheric mole fractions and assess the impact of policy on emission rates, it is necessary to demonstrate measurement equivalence at the highest levels of accuracy for assigned values of standards. Precise measurements of these species aid in determining small changes in their atmospheric abundance. A common source of standards/scales and/or well-documented agreement of different scales used to calibrate the measurement instrumentation are key to understanding many sets of data reported by researchers. This report describes the results of a comparison study among National Metrology Institutes and atmospheric research laboratories for the chlorofluorocarbons (CFCs) dichlorodifluoromethane (CFC-12), trichlorofluoromethane (CFC-11), and 1,1,2-trichlorotrifluoroethane (CFC-113); the hydrochlorofluorocarbons (HCFCs) chlorodifluoromethane (HCFC-22) and 1-chloro-1,1-difluoroethane (HCFC-142b); and the hydrofluorocarbon (HFC) 1,1,1,2-tetrafluoroethane (HFC-134a), all in a dried whole air sample. The objective of this study is to compare calibration standards/scales and the measurement capabilities of the participants for these halocarbons at trace atmospheric levels. The results of this study show agreement among four independent calibration scales to better than 2.5% in almost all cases, with many of the reported agreements being better than 1.0%.
The clinical outcome of minimally invasive Phase 3 Oxford unicompartmental knee arthroplasty
Authors: Pandit H. , Hamilton T. W. , Jenkins C. , Mellon S. J. , Dodd C. A. F. , Murray D. W. 
Published: November 2015

This prospective study reports the 15-year survival and ten-year functional outcome of a consecutive series of 1000 minimally invasive Phase 3 Oxford medial UKAs (818 patients, 393 men, 48%, 425 women, 52%, mean age 66 years; 32 to 88). These were implanted by two surgeons involved with the design of the prosthesis to treat anteromedial osteoarthritis and spontaneous osteonecrosis of the knee, which are recommended indications. Patients were prospectively identified and followed up independently for a mean of 10.3 years (5.3 to 16.6).At ten years, the mean Oxford Knee Score was 40 (standard deviation (sd) 9; 2 to 48): 79% of knees (349) had an excellent or good outcome. There were 52 implant-related re-operations at a mean of 5.5 years (0.2 to 14.7). The most common reasons for re-operation were arthritis in the lateral compartment (2.5%, 25 knees), bearing dislocation (0.7%, seven knees) and unexplained pain (0.7%, seven knees). When all implant-related re-operations were considered as failures, the ten-year rate of survival was 94% (95% confidence interval (CI) 92 to 96) and the 15-year survival rate 91% (CI 83 to 98). When failure of the implant was the endpoint the 15-year survival was 99% (CI 96 to 100).This is the only large series of minimally invasive UKAs with 15-year survival data. The results support the continued use of minimally invasive UKA for the recommended indications.Cite this article: Bone Joint J 2015;97-B:1493–99.
Which patients need critical care intervention after total joint arthroplasty?
Authors: Courtney P. M. , Melnic C. M. , Gutsche J. , Hume E. L. , Lee G-C. 
Published: November 2015

Older patients with multiple medical co-morbidities are increasingly being offered and undergoing total joint arthroplasty (TJA). These patients are more likely to require intensive care support, following surgery. We prospectively evaluated the need for intensive care admission and intervention in a consecutive series of 738 patients undergoing elective hip and knee arthroplasty procedures. The mean age was 60.6 years (18 to 91; 440 women, 298 men. Risk factors, correlating with the need for critical care intervention, according to published guidelines, were analysed to identify high-risk patients who would benefit from post-operative critical care monitoring. A total of 50 patients (6.7%) in our series required critical care level interventions during their hospital stay. Six independent multivariate clinical predictors were identified (p < 0.001) including a history of congestive heart failure (odds ratio (OR) 24.26, 95% confidence interval (CI) 9.51 to 61.91), estimated blood loss > 1000 mL (OR 17.36, 95% CI 5.36 to 56.19), chronic obstructive pulmonary disease (13.90, 95% CI 4.78 to 40.36), intra-operative use of vasopressors (OR 8.10, 95% CI 3.23 to 20.27), revision hip arthroplasty (OR 2.71, 95% CI 1.04 to 7.04) and body mass index > 35 kg/m2(OR 2.70, 95% CI 123 to 5.94). The model was then validated against an independent, previously published data set of 1594 consecutive patients. The use of this risk stratification model can be helpful in predicting which high-risk patients would benefit from a higher level of monitoring and care after elective TJA and aid hospitals in allocating precious critical care resources.Cite this article: Bone Joint J 2015;97-B:1512–18.
The effect of the anatomy of the distal humerus and proximal ulna on the positioning of the components in total elbow arthroplasty
Authors: Lenoir H. , Chammas M. , Micallef J. P. , Lazerges C. , Waitzenegger T. , Coulet B. 
Published: November 2015

Determining and accurately restoring the flexion-extension axis of the elbow is essential for functional recovery after total elbow arthroplasty (TEA). We evaluated the effect of morphological features of the elbow on variations of alignment of the components at TEA. Morphological and positioning variables were compared by systematic CT scans of 22 elbows in 21 patients after TEA. There were five men and 16 women, and the mean age was 63 years (38 to 80). The mean follow-up was 22 months (11 to 44). The anterior offset and version of the humeral components were significantly affected by the anterior angulation of the humerus (p = 0.052 and p = 0.004, respectively). The anterior offset and version of the ulnar components were strongly significantly affected by the anterior angulation of the ulna (p < 0.001 and p < 0.001). The closer the anterior angulation of the ulna was to the joint, the lower the ulnar anterior offset (p = 0.030) and version of the ulnar component (p = 0.010). The distance from the joint to the varus angulation also affected the lateral offset of the ulnar component (p = 0.046). Anatomical variations at the distal humerus and proximal ulna affect the alignment of the components at TEA. This is explained by abutment of the stems of the components and is particularly severe when there are substantial deformities or the deformities are close to the joint. Cite this article: Bone Joint J 2015;97-B:1539–45.
Bariatric surgery does not improve outcomes in patients undergoing primary total knee arthroplasty
Authors: Martin J. R. , Watts C. D. , Taunton M. J. 
Published: November 2015

Bariatric surgery has been advocated as a means of reducing body mass index (BMI) and the risks associated with total knee arthroplasty (TKA). However, this has not been proved clinically. In order to determine the impact of bariatric surgery on the outcome of TKA, we identified a cohort of 91 TKAs that were performed in patients who had undergone bariatric surgery (bariatric cohort). These were matched with two separate cohorts of patients who had not undergone bariatric surgery. One was matched 1:1 with those with a higher pre-bariatric BMI (high BMI group), and the other was matched 1:2 based on those with a lower pre-TKA BMI (low BMI group). In the bariatric group, the mean BMI before bariatric surgery was 51.1 kg/m2 (37 to 72), which improved to 37.3 kg/m2 (24 to 59) at the time of TKA. Patients in the bariatric group had a higher risk of, and worse survival free of, re-operation (hazard ratio (HR) 2.6; 95% confidence interval (CI) 1.2 to 6.2; p = 0.02) compared with the high BMI group. Furthermore, the bariatric group had a higher risk of, and worse survival free of re-operation (HR 2.4; 95% CI 1.2 to 3.3; p = 0.2) and revision (HR 2.2; 95% CI 1.1 to 6.5; p = 0.04) compared with the low BMI group. While bariatric surgery reduced the BMI in our patients, more analysis is needed before recommending bariatric surgery before TKA in obese patients. Cite this article: Bone Joint J 2015;97-B:1501–5.
An Anatomy of Tradition: The Case of the Charitêsion
Authors: Bruyn Theodore S. de 
Published: November 2015

Abstract This paper traces continuity and change in the structure and formulation of Demotic, Greek, and Coptic charitêsia (“good luck charms”) in Roman Egypt. Drawing on the theoretical work of Roy Rappaport and Catherine Bell, it argues that the producers of these charms created a sense of tradition by echoing and modulating pre-established forms of incantation. The resulting products combined both elasticity and specificity so as to be at once recognizable in a broad cultural context and relevant to specific audiences.
Ishtar Rejected: Reading a Mesopotamian Goddess in the Homeric Hymn to Aphrodite
Authors: Eisenfeld Hanne 
Published: November 2015

Abstract This paper argues that the poet of the Homeric Hymn to Aphrodite crafted his mythical narrative in conscious conversation with contemporary traditions surrounding the Mesopotamian goddess Ishtar. The poetic representation of Aphrodite in her encounter with Anchises flirts with characteristics appropriate to Ishtar-personal sexuality, high status within the pantheon, a role as divine patron to mortal kings-only to reject their relevance to Aphrodite. By recognizing that the Greek poet could exert agency in his adaption of Mesopotamian motifs, using them to delimit Aphrodite’s nature within the Greek pantheon, we can perceive the serious conceptual work that the Hymn is doing and the potential use of multicultural models within that process.
Cognitive vs. generative construction grammar: The case of coercion and argument structure
Authors: van Trijp Remi 
Published: November 2015

AbstractOne of the most salient hallmarks of construction grammar is its approach to argument structure and coercion: rather than positing many different verb senses in the lexicon, the same lexical construction may freely interact with multiple argument structure constructions. This view has however been criticized from within the construction grammar movement for leading to overgeneration. This paper argues that this criticism falls flat for two reasons: (1) lexicalism, which is the alternative solution proposed by the critics, has already been proven to overgenerate itself, and (2) the argument of overgeneration becomes void if grammar is implemented as a problem-solving model rather than as a generative competence model; a claim that the paper substantiates through a computational operationalization of argument structure and coercion in Fluid Construction Grammar. The paper thus shows that the current debate on argument structure is hiding a much more fundamental rift between practitioners of construction grammar that touches upon the role of grammar itself.
Diffusion trends and Nahuatlisms of American Spanish: Evidence from dialectal vocabularies
Authors: Cáceres-Lorenzo María-Teresa 
Published: November 2015

Abstract
Missionary linguistics and considerations of Nahuatl as a lingua franca lead us to propose that Nahuatlisms have historically been prominent in American Spanish. Diachronic studies show that after Spanish spelling was standardised, involving occasional losses and extensions of meaning, Aztec words were incorporated into Spanish language vocabularies in the Americas. Because 16th and 17th -century data provide inconsistent depictions of the spread of Nahuatlisms in the Caribbean and in South American regions, our research aims to collect data from American Spanish dialectal vocabularies to reconstruct regionalisation and diffusion trends of Nahuatlisms in the centuries that followed. Utilising quantitative and qualitative methodologies, we design a research study that identifies restricted and regional characteristics of more than 84% of Nahuatlisms and of remnants of Nahuatl words in the Caribbean and in South American regions.
Dry reforming of methane over Ni/CeO2 catalysts prepared by three different methods
Authors: Yahi Nora , Menad Saliha , Rodríguez-Ramos Inmaculada 
Published: November 2015

AbstractCerium-supported nickel catalysts with Ni loading close to 15%wt were synthesized using three different methods (microemulsion, sol-gel and autocombustion) with the aim to design efficient catalysts for the dry reforming of methane to produce syngas (H
Crystal structure of cleaved vaspin (serpinA12)
Authors: Pippel Jan , Kuettner E. Bartholomeus , Ulbricht David , Daberger Jan , Schultz Stephan , Heiker John T. , Sträter Norbert 
Published: November 2015

Abstract
The adipokine vaspin (serpinA12) is mainly expressed in white adipose tissue and exhibits various beneficial effects on obesity-related processes. Kallikrein 7 is the only known target protease of vaspin and is inhibited by the classical serpin inhibitory mechanism involving a cleavage of the reactive center loop between P1 (M378) and P1′ (E379). Here, we present the X-ray structure of vaspin, cleaved between M378 and E379. We provide a comprehensive analysis of differences between the uncleaved and cleaved forms in the shutter, breach, and hinge regions with relation to common molecular features underlying the serpin inhibitory mode. Furthermore, we point out differences towards other serpins and provide novel data underlining the remarkable stability of vaspin. We speculate that the previously reported FKGx1Wx2x3 motif in the breach region may play a decisive role in determining the reactive center loop configuration in the native vaspin state and might contribute to the high thermostability of vaspin. Thus, this structure may provide a basis for future mutational studies.
Functional and Parametric Estimation in a Semi- and Nonparametric Model with Application to Mass-Spectrometry Data
Authors: Ma Weiping , Feng Yang , Chen Kani , Ying Zhiliang 
Published: November 2015

AbstractMotivated by modeling and analysis of mass-spectrometry data, a semi- and nonparametric model is proposed that consists of linear parametric components for individual location and scale and a nonparametric regression function for the common shape. A multi-step approach is developed that simultaneously estimates the parametric components and the nonparametric function. Under certain regularity conditions, it is shown that the resulting estimators is consistent and asymptotic normal for the parametric part and achieve the optimal rate of convergence for the nonparametric part when the bandwidth is suitably chosen. Simulation results are presented to demonstrate the effectiveness and finite-sample performance of the method. The method is also applied to a SELDI-TOF mass spectrometry data set from a study of liver cancer patients.
Radiative Three-Dimensional Flow with Chemical Reaction
Authors: Hayat Tasawar , Muhammad Taseer , Shehzad Sabir Ali , Alsaedi Ahmed , Al-Solamy Falleh 
Published: November 2015

Abstract
We discuss the three-dimensional boundary layer flow of Maxwell nanofluid in the present article. The flow is caused due to bidirectional stretching surface. An applied magnetic field is taken into account. Heat and mass transfer characteristics are considered in the presence of thermal radiation, Brownian motion, thermophoresis and chemical reaction effects. Mathematical modelling is made under a low magnetic Reynolds number and Rosseland’s approximation. Expressions of series solutions for velocities, temperature and concentration are developed. Impacts of influential parameters on the temperature and concentration are sketched and examined. Numerical values of local Nusselt and Sherwood numbers are computed and analyzed. We found that an increase in thermophoresis and Brownian motion parameters enhanced the temperature field and thermal boundary layer thickness. The concentration field reduced gradually when we enhance the values of Lewis number and chemical reaction parameter. The values of local Nusselt number are higher for a larger radiation parameter.