bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing the nutritional value and antioxidant properties of foxtail millet by solid‐state fermentation with edible fungi
Authors: Lin Tong , Li Zhanyong , Fan Gongjian , Xie Chunyan 
Published: July 2024

AbstractFoxtail millet is typically dehulled before consumption or processing. However, foxtail millet bran also contains abundant phenolic compounds and other nutrients. Edible fungi have rich extracellular enzyme systems; are environmentally friendly and safe for consumption; and have been shown to effectively degrade lignin and cellulose. This study aimed to screen edible fungi that can effectively ferment undehusked foxtail millet, improving its nutritional value and antioxidant properties through solid‐state fermentation (SSF). The results demonstrated that fermentation utilizing Pleurotus geesteranus exhibited significant improvements in both the phenolic compound content and antioxidant properties of foxtail millet, with the optimal fermentation period determined to be 30 days. The physical and functional properties of fermented undehusked foxtail millet (FFM) flour were effectively improved, increasing crude protein, vitamin C, and crude polysaccharide contents by 11.46%, 27.78%, and 54.17%, respectively. In vitro scavenging activities of FFM were 73.19%, 93.86%, and 63.75% for 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS·+), and superoxide anion radicals (O2−), respectively. The total antioxidant capability (T‐AOC) and superoxide dismutase (SOD) activity of FFM were 1.01 mM Trolox equivalents (TE)/g and 89.05 U/g, respectively. Additionally, T‐AOC, SOD, and glutathione peroxidase (GSH‐Px) activities increased, whereas malondialdehyde (MDA) levels decreased in the heart, liver, and kidneys of mice treated with FFM flour, indicating enhanced antioxidant capacity. Therefore, fermentation with edible fungi is suitable for improving the nutritional composition and antioxidant properties of foxtail millet.
Meteorological data from Badwater, Death Valley National Park 1998 to 2019
Authors: McKay Christopher P. 
Published: July 2024

AbstractWe installed a meteorological recording system at Badwater (elev. −75 m), the lowest point in Death Valley, California and recorded data over the period 1998–2019. A second station (the Outhouse Station) was established nearby from 2014 to 2019. Here, we report on and publicly archive the data from these two stations. Of interest was the comparison between two air temperature measurements at the Badwater Station, the first with an aspirated platinum resistance temperature device and the second with a thermistor probe in a passive sun shield. During the hottest periods of the summer when temperatures were typically between 30°C at night and 50°C daily peak, the passively shielded sensor indicated up to 0.5°C warmer than the aspirated temperature sensor due to radiative effects. The data suggest a correction for radiative heating of (T–35)/30, for T > 35°C, where, T, is the uncorrected temperature reading of a passively shielded sensor subtracted after any calibration at lower temperatures. Our station was the first precision temperature measurements at Badwater. A longer record exists for the reporting station near the visitor's centre at the Furnace Creek. The summer temperature maxima at the Badwater site correlate well with the values the same day from the Furnace Creek site. The daily maximum temperatures in winter at the Badwater site appear to be about 1°C lower than at the Furnace Creek site. The largest differences are in the minimum temperatures for which the Badwater site averages about 2–3°C warmer than the Furnace Creek site.
Colorimetric sensing of lead ion using gold nanorod with enhanced sensitivity via catalytic etching
Authors: Wang Suyan , Sun Jingbo , Cao Jiafeng , Lu Kun , Xu Dong 
Published: July 2024

AbstractLead, a prevalent heavy metal, poses significant risks to human health through various exposure pathways. Herein, we propose an extremely sensitive assay toward lead ion (Pb2+) using gold nanorods (GNRs) as probes based on its catalytic activity on etching gold in the presence of 2‐mercaptoethanol and sodium thiosulfate. In the presence of Pb2+, etching predominantly occurs at the two ends of GNRs, leading to the reduction of aspect ratio and the corresponding blueshift of the localized surface plasmon resonance (LSPR). With increasing Pb2+ concentration over the range of 0–50 μM, the color of GNR solution lightens, ultimately becoming colorless. The wavelength shift (Δλ) of LSPR is highly dependent on Pb2+ concentration, with a linear regression equation of Δλ = 10.05ln[Pb2+] + 9.59 and an R2 = 0.995. The assay demonstrates high selectivity for Pb2+ over other potentially interfering ions such as Cu2+ because of its special catalytic activity in the etching of GNRs and the complexing ability of 2‐mercaptoethanol and sodium thiosulfate. Validation of the assay was accomplished by analyzing several forest‐derived food samples, affirming the accuracy in real‐world scenarios. The assay we developed holds promise for many applications in environmental protection and food safety.
A staging table of Balkan crested newt embryonic development to serve as a baseline in evolutionary developmental studies
Authors: Vučić Tijana , Drobnjaković Marija , Ajduković Maja , Bugarčić Marko , Wielstra Ben , Ivanović Ana , Cvijanović Milena 
Published: July 2024

AbstractThere is an increased interest in the evolution and development of newts from the genus Triturus because: (1) morphological differentiation among the nine constituent species largely corresponds to different ecological preferences, (2) hybridization between different species pairs has various evolutionary outcomes in terms of life history traits and morphology, and (3) the genus expresses a balanced lethal system that causes arrested growth and death of half of the embryos. These features provide natural experimental settings for molecular, morphological, and life‐history studies. Therefore, we produce a staging table for the Balkan crested newt (T. ivanbureschi). We provide detailed descriptions of 34 embryonic stages based on easily observable and interpretable external morphological characters, to ensure reproducibility. Compared with previous staging tables for Triturus, we include a vastly increased sample size and provide high‐resolution photographs in lateral, ventral, and dorsal view, complemented by videos of specific developmental periods, and accompanied by detailed explanations on how to delineate the specific stages. Our staging table will serve as a baseline in comparative studies on Triturus newts: an emerging model system in evolutionary and developmental studies.
船舶を活用した災害医療〜乗船における課題と今後の展望〜(Challenges and prospects for ship–based medical services in disaster: in relation to boarding ships)
Authors: 航 野口 , 飛鳥 土谷 , 弘道 青木 , 誠司 守田 , 儀英 中川 , 吉彦 山田 
Published: July 2024

要旨【目的】阪神・淡路大震災以降の大規模災害の経験から，国は「災害時等における船舶を活用した医療提供体制の整備の推進に関する法律」を整備し，医療支援に船舶を活用する方針を示した。一方，災害時には大型船舶が港へ着岸できない可能性が高いため，乗船の課題がある。そこで，実証訓練「被災者を陸から小型船舶を使用して沖合に停泊する大型船舶へ移乗させる」を行い，船から船へ「海上」で安全に移乗できる被災者要件や船舶課題を抽出し，災害時の船舶活用を検討した。【対象】模擬被災者計38名（軽症・中等症患者，避難者）に対して，小型船舶が停泊可能な桟橋前の海岸で，乗船前トリアージを行った。続いて海上で小型船舶から大型海洋調査研修船へ移乗する訓練を行った。【結果】歩行可能である患者や要配慮者が選定されれば，小型船舶から大型船舶へ海上乗船できることが判明した。天候による船舶間距離や波高変化が接舷と移乗タイミングに大きく影響した。関係者アンケートでは，乗船トリアージと船舶間の移乗における安全性確保の重要性が指摘された。【結語】災害時に小型船舶から大型船舶へ移乗する場合を想定し，船舶の安全設備の充実，乗船可能な患者や要配慮者要件の整理，事前訓練による安全性の確認と関係者の連携を行うことで，船舶活用の機会が広がることが期待される。
Effects of antiarrhythmic drug responsiveness and diagnosis‐to‐ablation time on outcomes after catheter ablation for persistent atrial fibrillation
Authors: Kim Hong‐Ju , Kim Daehoon , Kim Kipoong , Choi Sung Hwa , Kim Moon‐Hyun , Park Je‐Wook , Yu Hee Tae , Kim Tae‐Hoon , Uhm Jae‐Sun , Joung Boyoung , Lee Moon‐Hyoung , Pak Hui‐Nam 
Published: July 2024

AbstractBackgroundThe impact of delaying atrial fibrillation catheter ablation (AFCA) for antiarrhythmic drug (AAD) management on the disease course remains unclear. This study investigated AFCA rhythm outcomes based on the diagnosis‐to‐ablation time (DAT) and AAD responsiveness in participants with persistent AF (PeAF).MethodsWe included data from 1038 AAD‐resistant PeAF participants, all of whom had a clear time point for AF diagnosis, especially PeAF at diagnosis time, and had undergone an AFCA for the first time. Participants who experienced recurrences of paroxysmal type on AAD therapy were analyzed as a cohort of AAD‐partial responders; those maintaining PeAF on AAD were AAD‐non‐responders. We determined the DAT cutoff for best discriminating long‐term rhythm outcomes using a maximum log‐likelihood estimation method based on the Cox proportional hazard regression model.ResultsOf the participants (79.8% male; median age 61), 806 (77.6%) were AAD‐non‐responders. AAD‐non‐responders had a higher body mass index and a larger left atrial diameter than AAD‐partial‐responders. They also had a higher incidence of AF recurrence after AFCA (adjusted hazard ratio 1.75, 95% confidence interval 1.33–2.30; log‐rank p < .001) compared to AAD‐partial‐responders. The maximum log‐likelihood estimation showed bimodal cutoffs at 22 and 40 months. The optimal DAT cutoff rhythm outcome was 22 months, which discriminated better in the AAD‐partial‐responders than in the AAD‐non‐responders.ConclusionsBoth DAT and AAD responsiveness influenced AFCA rhythm outcomes. Delaying AFCA to a DAT of longer than 22 months was inadvisable, particularly in the participants in whom PeAF was changed to paroxysmal AF during AAD therapy.
Evaluation of bone integrity around the acetabular cup using noninvasive laser resonance frequency analysis
Authors: Hatakeyama Takuto , Nakashima Daisuke , Mikami Katsuhiro , Oya Akihito , Fujie Atsuhiro , Sujino Asahi , Nakamura Masaya , Nagura Takeo 
Published: July 2024

AbstractResonance frequency analysis (RFA) is valuable for assessing implant status. In a previous investigation, acetabular cup fixation was assessed using laser RFA and the pull‐down force was predicted in an in vitro setting. While the pull‐down force alone is sufficient for initial fixation evaluation, it is desirable to evaluate the bone strength of the foundation for subsequent fixation. Diminished bone quality causes micromotion, migration, and protracted osseointegration, consequently elevating susceptibility to periprosthetic fractures and failure of ingrained trabecular bone. Limited research exists on the evaluation of bone mineral density (BMD) around the cup using RFA. For in vivo application of laser RFA, we implemented the sweep pulse excitation method and engineered an innovative laser RFA device having low laser energy and small dimensions. We focused on a specific frequency range (2500–4500 Hz), where the peak frequency was presumed to be influenced by foundational density. Quantitative computed tomography with a phantom was employed to assess periprosthetic BMD. Correlation between the resonance frequency within the designated range and the density around the cup was evaluated both in the laboratory and in vivo using the novel laser RFA device. The Kruskal–Wallis test showed robust correlations in both experiments (laboratory study: R = 0.728, p < 0.001; in vivo study: R = 0.619, p < 0.001). Our laser RFA system can assess the quality of bone surrounding the cup. Laser RFA holds promise in predicting the risk of loosening and might aid in the decision‐making process for additional fixation through screw insertion.
Late Pleistocene to Holocene vegetation changes in southeastern Patagonia (49° S): landscape changes related to disturbances
Authors: Merino‐Campos Víctor , Sottile Gonzalo David , de Porras María Eugenia , Tonello Marcela Sandra 
Published: July 2024

ABSTRACTSoutheastern Patagonia's (49° S) post‐glacial history inferred from high Andean lake sediments provides new insights regarding Late Pleistocene and Holocene vegetation dynamics at the eastern margin of the Southern Patagonian Icefield. The fossil records of pollen, charcoal and geochemical data from tephra layers from Laguna Chiquita and Laguna Gemelas Este were analysed to reveal past landscape dynamics related to vegetation changes, fire and volcanic events from ca. 15 200 cal a
bp to the present. Nothofagus forest expanded over shrubland communities sometime between 15 200 and 4600 cal a
bp, along with at least three disturbance sources related to the volcanic eruptions of Lautaro, Aguilera and Hudson, important local fire episodes, and neoglacial advances. Major charcoal deposition reveals moderate fire activity during the Late Pleistocene related to an open landscape characterised by a grass/shrub steppe. Local glacier advances may have affected the Laguna Gemelas Este sedimentation. Tephra deposition events do not correlate to vegetation changes inferred from the Laguna Gemelas Este and Laguna Chiquita pollen records. Late Holocene eastern Andean forest changes and fire activity at 49° S match other southern palaeoenvironmental records (50–52° S) suggesting that changes in the Southern Westerly Wind latitudinal position and intensity drove major palaeovegetation and fire dynamics before the European settlement. In the last centuries, fire and vegetation changes have been closely related to an increase in local ignition sources and the introduction of alien species.
Similar QALY gain in primary and revision knee arthroplasty: A cost analysis and Markov model
Authors: Möller Soeren , Gautschi Nora , Möller Klaus , Hamilton David F. , Giesinger Karlmeinrad 
Published: July 2024

AbstractPurposeThe aim of this study is to investigate the cost‐effectiveness of revision total knee arthroplasty compared to primary total knee arthroplasty in terms of cost‐per‐quality‐adjusted life year (QALY).MethodsData were retrieved for all primary and revision total knee replacement (TKA) procedures performed at a tertiary Swiss hospital between 2006 and 2019. A Markov model was created to evaluate revision risk and we calculated lifetime QALY gain and lifetime procedure costs through individual EuroQol 5 dimension (EQ‐5D) scores, hospital costs, national life expectancy tables and standard discounting processes. Cost‐per‐QALY gain was calculated for primary and revision procedures.ResultsEQ‐5D data were available for 1343 primary and 103 revision procedures. Significant QALY gains were seen following surgery in all cases. Similar, but significantly more QALYs were gained following primary TKA (PTKA) (5.67 ± 3.98) than following revision TKA (RTKA) (4.67 ± 4.20). Cost‐per‐QALY was €4686 for PTKA and €10,364 for RTKA. The highest average cost‐per‐QALY was seen in two‐stage RTKA (€12,292), followed by one‐stage RTKA (€8982).ConclusionRTKA results in a similar QALY gain as PTKA. The costs of achieving health gain are two to three times higher in RTKA, but both procedures are highly cost‐effective.Level of EvidenceEconomic level II.
Biotechnological Production of Fungal Colorants
Authors: Bergmann Pia , Berger R. G. , Ersoy F. , Krings U. 
Published: July 2024

Da eine globale Transformation in Richtung zirkulärer Bioökonomie auf nachhaltige Prozesse und umweltfreundliche Produkte angewiesen ist, werden in dieser Arbeit Alternativen für aktuell eingesetzte Farbstoffe untersucht. Die biotechnologische Produktion von Farbstoffen aus Pilzen wird als Lösungsstrategie vorgeschlagen.Zwei verschiedene Spezies wurden auf ihr Potential als Farbstoff‐Produzenten untersucht: der Gemeine Schwefelporling (Laetiporus sulphureus) und der Zottige Schillerporling (Inonotus hispidus). Beide Arten sind bekannt dafür, sowohl im Fruchtkörper, als auch im Myzel in flüssiger Nährkultur farbige Moleküle zu synthetisieren. L. sulphureus produziert die orangen Laetiporsäuren und I. hispidus bildet das gelbe Hispidin, ein bekanntes Antioxidant mit vielen weiteren Bioaktivitäten.Die Kultivierung beider Spezies wurde in dieser Arbeit vom Schüttelkolben bis zum 4 bzw. 7 L Maßstab im Bioreaktor vergrößert und die Nährmedien optimiert. Durch den Vergleich vier verschiedener L. sulphureus Stämme wurde der potenteste Produktionsstamm ausgewählt und erzielte Ausbeuten von rund 1 g/L Laetiporsäure. Bei der Kultivierung von I. hispidus wurden verschiedene physikalische und chemische Einflussfaktoren zur Steigerung der Hispidin‐Ausbeute getestet. Der Einsatz von Belichtung und oxidativem Stress stimulierte die Farbstoffsynthese, genau wie dem Nährmedium zugesetzte Prekursoren. Alle Effektoren wurden in parallelen Kultivierungen in Bioreaktoren zweier verschiedener Bauarten getestet und eine Ausbeute von 5,5 g/L Hispidin erzielt. Verschiedene Produktaufarbeitungs‐Strategien wurden etabliert, von der klassischen Extraktion bis zum Zwei‐Phasen‐System. Die zuvor geringe Stabilität der Laetiporsäure‐Extrakte konnte durch Stickstoff und Lagerung bei niedrigen Temperaturen stabilisiert werden und das Potential für die Anwendung in Textilien, Kosmetika und Lebensmitteln wurde demonstriert.Zusammenfassend wurde in dieser Arbeit anhand von zwei Beispielen gezeigt, dass die biotechnologische Produktion von Pilzfarbstoffen möglich ist. Die Maßstabsvergrößerung von Labor bis zur Pilotanlage wurde berichtet und die Kombination von chemischen und physikalischen Einflussfaktoren sorgte für Ausbeuten im g/L Bereich, die einen entsprechenden Bioprozess wettbewerbsfähig mit konventionellen Prozessen für natürliche Farbstoffe machen.
Capturing Transient Events in Series: A Review of Framing Photography
Authors: Yao Yunhua , Liu Xianglei , Qi Dalong , Yao Jiali , Jin Chengzhi , He Yu , Huang Zhengqi , He Yilin , Shen Yuecheng , Deng Lianzhong , Wang Zhiyong , Sun Zhenrong , Liang Jinyang , Zhang Shian 
Published: July 2024

AbstractObserving transient events is of great importance for understanding fundamental principles and further controlling the related processes. To surmount the limitations of human vision, special tools are required to detect and record these transient events. Among existing approaches, framing photography stands out by its high spatiotemporal resolution with a 2D field of view and low crosstalk between adjacent frames. This review aims to summarize the technical routes of framing photography and provide a guide for choosing suitable tools for the observation of transient phenomena. The basic principles of framing photography are introduced and then an overview of the main categories by analyzing the system configurations and working principles are presented. Then, the existing devices are classified into mechanical, electrical, and optical framing photography. For each category, representative techniques and applications are discussed. Finally, a prospect for framing photography is provided.
Hyphenation of microflow chromatography with electrospray ionization mass spectrometry for bioanalytical applications focusing on low molecular weight compounds: A tutorial review
Authors: Girel Sergey , Meister Isabel , Glauser Gaetan , Rudaz Serge 
Published: July 2024

AbstractBenefits of miniaturized chromatography with various detection modes, such as increased sensitivity, chromatographic efficiency, and speed, were recognized nearly 50 years ago. Over the past two decades, this approach has experienced rapid growth, driven by the emergence of mass spectrometry applications serving ‐omics sciences and the need for analyzing minute volumes of precious samples with ever higher sensitivity. While nanoscale liquid chromatography (flow rates <1 μL/min) has gained widespread recognition in proteomics, the adoption of microscale setups (flow rates ranging from 1 to 100 μL/min) for low molecular weight compound applications, including metabolomics, has been surprisingly slow, despite the inherent advantages of the approach. Highly heterogeneous matrices and chemical structures accompanied by a relative lack of options for both selective sample preparation and user‐friendly equipment are usually reported as major hindrances. To facilitate the wider implementation of microscale analyses, we present here a comprehensive tutorial encompassing important theoretical and practical considerations. We provide fundamental principles in micro‐chromatography and guide the reader through the main elements of a microflow workflow, from LC pumps to ionization devices. Finally, based on both our literature overview and experience, illustrated by some in‐house data, we highlight the critical importance of the ionization source design and its careful optimization to achieve significant sensitivity improvement.
The role of immune checkpoint inhibitors: Variable number of tandem repeat (VNTR) polymorphism in the second exon of the P‐selectin glycoprotein ligand‐1 (PSGL‐1) gene polymorphism in multiple myeloma
Authors: Oyaci Yasemin , Pehlivan Mustafa , Pehlivan Sacide , Cinli Tahir Alper , Tuncel Fatima Ceren , Ertas Elif , Serin Istemi 
Published: July 2024

AbstractSomatic mutations and polymorphisms may play a role in multiple myeloma (MM) susceptibility and survival. One of the immune checkpoint inhibitors is P‐selectin glycoprotein ligand‐1 (PSGL‐1); the majority of tumor‐infiltrating leukocytes express PSGL‐1, causing T cell and immune inhibition via PSGL‐1 mediator molecules. We aimed to investigate the effect of variable number of tandem repeat (VNTR) polymorphism in the second exon of the PSGL‐1 gene on MM susceptibility, response to treatment and survival in our patient group. A total of 238 patients diagnosed with MM between January 2010 and January 2021 and 162 healthy individuals as a control group were included in this cross‐sectional study. The genotypes of the VNTR polymorphism in the second exon of the PSGL‐1 gene were statistically compared between patients and healthy controls; the statistically significant effects of the genotypes on response to first‐line treatment and survival were examined. The AC genotype was significantly higher in healthy controls compared to patients diagnosed with MM (p < 0.001). The median PFS in patients with AA/AB/AC was 56 months, while it was 100 months in patients with BB/CC. The hazard ratio of 1.34 for PFS was found to be clinically significant and having the BB/CC genotype could provide a longer PFS compared to others, but it was not statistically significant due to the sample size. Our study results will shed light on new study plans in terms of immune checkpoint target therapies among conventional treatment preferences in MM.
Error bounds for the approximation of matrix functions with rational Krylov methods
Authors: Simunec Igor 
Published: July 2024

AbstractWe obtain an expression for the error in the approximation of and with rational Krylov methods, where is a symmetric matrix, is a vector and the function admits an integral representation. The error expression is obtained by linking the matrix function error with the error in the approximate solution of shifted linear systems using the same rational Krylov subspace, and it can be exploited to derive both a priori and a posteriori error bounds. The error bounds are a generalization of the ones given in Chen et al. for the Lanczos method for matrix functions. A technique that we employ in the rational Krylov context can also be applied to refine the bounds for the Lanczos case.