bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spinal juvenile (Type III) extradural-intradural arteriovenous malformations
Authors: Gross Bradley A. , Du Rose 
Published: February 2014

ObjectOwing to their rarity, demographics, natural history, and treatment, results for spinal juvenile (Type III) extradural-intradural arteriovenous malformations (AVMs) are frequently only provided in case report format.MethodsA pooled analysis was performed utilizing the PubMed database through April 2013. Individualized patient data were extracted to elucidate demographics, hemorrhage risk, and treatment result information.ResultsTwenty-nine studies describing 51 patients were included. The mean age at presentation was 15.0 ± 10.5 years with a slight male predilection (63%, 1.7:1 sex ratio). Presentation modality included progressive deficits in 35%, hemorrhage in 31%, acute deficits not attributed to hemorrhage in 22%, and asymptomatic/incidental in 12% of patients. The annual hemorrhage rate was 2.1%; statistically significant risk factors for hemorrhage included presentation age (HR 0.39 [95% CI 0.18–0.87]) and associated aneurysms (HR 8.74 [95% CI 1.76–43.31]). Seventy-seven percent of patients underwent treatment; after a mean follow-up of 2.6 ± 3.2 years, 73% were improved, 10% were the same, and 17% were worse neurologically. Of 25 cases with described angiographic results, 8 lesions were obliterated (32%). Of these 25 patients, 8 had AVMs with associated aneurysms, and the aneurysm was obliterated in all 8 patients. Over the course of 57.9 patient-years of follow-up, including 55.3 patient-years for partially treated AVMs, no hemorrhages were described, reflecting a trend toward protection from hemorrhage after treatment (p = 0.12, likelihood ratio test).ConclusionsSpinal juvenile (Type III) extradural-intradural AVMs commonly present symptomatically. Associated arterial aneurysms increase their hemorrhage risk, and protection from hemorrhage may be achieved from partial obliteration of these lesions, particularly if targeted toward associated aneurysms.
Poclain Hydraulics, se mondialiser tout en s'enracinant
Authors: Bataille Laurent 
Published: February 2014

Poclain Hydraulics exporte 80 % de sa production et s’est implantée dans dix-neuf pays. Fruit d’une saga familiale, elle est devenue une leader mondial en restant attachée à des valeurs que beaucoup proclament, et qu’elle met en application...
Imaginarios urbanos de la discapacidad y la exclusión
Authors: Narváez Tijerina Adolfo Benito , Soto Canales Karina 
Published: February 2014

Este trabajo presenta los resultados de una investigación de campo sobre los imaginarios de la discapacidad en la ciudad de Monterrey, México. Se presentan antecedentes sobre la importancia y pertinencia de los estudios urbanos basados en los imaginarios sociales. Se hace una descripción del método con el que se realizó el trabajo, encontrándose que por la forma de abordar el tema, así como por la tradición disciplinar, se trabajaría con métodos cualitativos, decidiéndose por la recopilación de historias de vida de personajes que han atravesado por discapacidades no permanentes. Se presentan cinco historias de vida, resaltando las descripciones de la relación de cada personaje entrevistado con la ciudad y los ciudadanos. Se reflexiona finalmente sobre el papel que juega el imaginario de la discapacidad como elemento para entender los comportamientos de la ciudadanía frente a esta minoría y de cómo a través de la comprensión de las visiones exploradas, es posible explicar que las formas de la ciudad y de la arquitectura marginan y excluyen a esta minoría
Aquest treball presenta els resultats d’una investigació de camp sobre els imaginaris de la discapacitat a la ciutat de Monterrey, Mèxic. Es presenten antecedents sobre la importància i pertinència dels estudis urbans basats en els imaginaris socials. Es fa una descripció del mètode amb el que es va realitzar el treball, trobant que per la forma d’abordar el tema, així com per la tradició disciplinar, es treballaria amb mètodes qualitatius, decidint-se per la recopilació d’històries de vida de personatges que han patit discapacitats no permanents. Es presenten cinc històries de vida, ressaltant les descripcions de la relació de cada personatge entrevistat amb la ciutat i els ciutadans. Es reflexiona finalment sobre el paper que juga l’imaginari de la discapacitat com element per entendre els comportaments de la ciutadania front a aquesta minoria i com a través de la comprensió de les visions explorades és possible explicar que les formes de la ciutat i de l’arquitectura marginen i exclouen a aquesta minoria.
On this work are presented the main results of a field research about urban imaginaries of disability in Monterrey, Mexico. First presents the background about importance and pertinence of studying the city from social imaginaries theory. Second presents the research method, that from research main theme and field tradition, are decided work with qualitative methods, decided for the life stories recompilation from persons with a non-permanent disability. Third are presented five life stories focusing on the description of relationships between the person, the city and its inhabitants. Finally are presented a few reflections about the role that plays disability imaginaries as an element to understand the behaviour of citizens in front of these minority and how throw the comprehension of explored visions in this work, it is possible explain that the urban and architectural forms are vehicles to exclude the disability’s minority
An Immunohistochemical Analysis of a Newly Developed, Mouse Monoclonal p40 (BC28) Antibody in Lung, Bladder, Skin, Breast, Prostate, and Head and Neck Cancers
Authors: Tacha David , Bremer Ryan , Haas Thomas , Qi Weiman 
Published: February 2014

Context.—Immunohistochemistry is important to the pathologist for accurate diagnosis of lung cancer. In recent studies, a rabbit polyclonal p40 (RPp40) antibody demonstrated equivalent staining versus anti-p63 in lung squamous cell carcinoma, and superior specificity because it stains a lesser percentage of lung adenocarcinoma.
Objectives.—To develop an anti-p40 mouse monoclonal antibody (MMp40) for immunohistochemistry, and to evaluate its sensitivity and specificity in normal and neoplastic tissues, with emphasis on lung cancer.
Design.—The MMp40 (BC28) antibody was developed and tested for specificity and sensitivity on normal (n = 34) and neoplastic tissues (n = 493). Staining of MMp40, p63, and RPp40 were directly compared in lung cancers, and MMp40 was evaluated in breast, bladder, skin, prostate, and head and neck cancers. Benign prostate glands and prostatic intraepithelial neoplasia were also tested in a direct comparison of MMp40 versus p63.
Results.—The MMp40 provided equivalent staining versus RPp40 and p63 in lung squamous cell carcinoma, but stained a lesser percentage of lung adenocarcinoma than p63 did. The MMp40 staining was observed in a greater percentage of urothelial carcinomas, squamous and basal cell skin cancers, and head and neck cancers of squamous cell origin. No breast-infiltrating ductal carcinomas or prostatic adenocarcinomas were stained. The MMp40 expression in basal cells of prostate glands and prostatic intraepithelial neoplasia were almost identical to those of p63.
Conclusion.—The MMp40 (BC28) monoclonal antibody is a high-quality screening antibody for determining squamous cell carcinoma in lung cancers, skin cancers of squamous or basal cell origin, squamous cell head and neck cancers, and urothelial carcinomas.
Nancy Huston : penser l’identité multiple
Authors: Balint-Babos Adina 
Published: February 2014

Le dialogue entre la construction de soi et l’espace géographique est loin d’être transparent, d’où notre intérêt à questionner comment se dé/construit le soi au croisement de l’Ouest canadien et de Paris. « On ne naît pas (un) soi, on le devient. Le soi est une construction péniblement élaborée », affirme Nancy Huston. Comment l’expression de soi à la rencontre du mot peut-elle acquérir une valeur subversive? Et quel rapport avec l’espace « réel » ou imaginaire? Ou encore, comment être écrivaine et habiter un « entre-deux-langues » (Daniel Sibony)? Par l’analyse de textes essayistiques de Désirs et réalités et Âmes et corps, en passant par Lettres parisiennes, nous proposons de dégager une pensée du « devenir-écrivaine » à la lumière de trois axes : l’avènement du soi multiple, le retour aux sources et la grâce de l’entre-deux. Il s’agira de réfléchir à une poétique de la traversée des frontières en interrogeant la singularité d’une oeuvre-passerelle entre le Canada et la France.
Lise Gaboury-Diallo : entre l’esprit cartésien et le réalisme merveilleux
Authors: Arentsen Maria Fernanda 
Published: February 2014

Ce travail propose une lecture de la nouvelle de Lise Gaboury-Diallo « Errances lointaines », publiée dans le recueil Lointaines (2010). On y analyse les mécanismes par lesquels la romancière manitobaine réussit à susciter un nouveau regard par rapport à la folie par le biais d’un discours rafraîchissant impliquant la présentation d’une nouvelle vision du monde qui remet en question certaines valeurs des sociétés modernes, comme « l’esprit cartésien ». Plus précisément, ce travail analyse le récit de la vie de Kady, jeune femme africaine supposément folle, à la lumière des théories sur le réalisme magique ou merveilleux, tel que défini par Alejo Carpentier et Jacques Stéphan Alexis. La perspective réaliste merveilleuse permet à l’auteure de contester les catégories binaires rigides des sociétés occidentales et d’introduire une nouvelle version de l’histoire des femmes, ce qui suppose une remise en question de la société patriarcale permettant d’offrir de nouvelles possibilités d’être au féminin, même si cela implique une rupture avec les relations humaines. On analysera comment ce récit subversif réussit à contester en même temps les valeurs des sociétés modernes (l’esprit cartésien) et des sociétés traditionnelles (le patriarcat), tout en s’insérant dans le dialogue multiculturel de l’Ouest canadien comme une voix inquiétante et provocante.
L’écosystème d’innovation universitaire de Aalto : une contribution au repérage des acteurs impliqués lors de la phase d’émergence
Authors: Froehlicher Thomas , Barès Franck 
Published: February 2014

L’objectif de cet article est de mieux comprendre comment l’écosystème d’innovation de Aalto, dans la région d’Helsinki en Finlande, s’est structuré au début des années 2000. En s’appuyant tant sur une analyse de données secondaires que sur les principes d’une analyse structurale de réseau, nous avons procédé au repérage des acteurs et de leurs liens au cours de la période dite d’émergence de cet écosystème. Les résultats montrent la coexistence de deux espaces organisés comme des réseaux sociocognitifs pouvant entrer en interaction et se renforcer mutuellement. Un espace territorialisé, centré sur une dynamique d’innovation s’appuyant sur la stratégie de convergence des trois recteurs impliqués sur Aalto. Un espace déterritorialisé construit par une communauté d’acteurs centrée sur l’affirmation de propositions et d’idées destinées à la mise en oeuvre de nouvelles pratiques de gouvernance de l’innovation.
Thermodynamic and dynamic effects on regional monsoon rainfall changes in a warmer climate
Authors: Endo Hirokazu , Kitoh Akio 
Published: February 2014

AbstractThis study investigates thermodynamic and dynamic effects on regional monsoon rainfall changes in a warmer climate, by using 20 climate model outputs in the Coupled Model Intercomparison Project (CMIP) Phase 5. In a warmer climate, rainfall is projected to increase in most monsoon regions. However, the rates of increase are quite different among the monsoon regions. A diagnosis based on a linearized moisture budget equation reveals that the regional differences of the rainfall change are largely explained by differences in the dynamic effect. In the Asian monsoon regions, monsoon circulation slows down at a much lower rate than in the other monsoon regions; in addition, surface evaporation increases at a higher rate, resulting in a much larger increase in rainfall. These features are commonly found in both CMIP Phase 3 and Phase 5 model projections.
Study on the process of fermentation coupling with foam fractionation and membrane module for nisin production
Authors: Cui Xiaoying , Zhang Da , Zheng Huijie , Wu Zhaoliang , Cui Shaofei , Dong Kai 
Published: February 2014

ABSTRACTNisin, an antimicrobial peptide, is commercially used as a food preservative and a promising alternative in medical applications for inhibiting bacterial infection in both humans and livestock. It is produced by fermentation using certain strains of Lactococcus lactis ssp. lactis. In traditional fermentation, the yield of nisin has always been limited by adsorption of nisin onto its producer, enzymatic degradation and product inhibition. This limitation can be solved by fast removal of the product from the broth during fermentation. In the current work, a technology of fermentation coupling with foam fractionation and membrane module was developed to achieve in situ removal of nisin produced by L. lactis ssp. lactis ATCC 11454 from the broth. The effects of air flow rate, the initial aeration time and interval time on the performance of the technology were studied to increase the yield of nisin. The results showed that under the optimal conditions of air flow rate 60 mL/min, the initial aeration time of the fourth hour and regular 30‐min interval, the total nisin titer reached 3946 IU/mL, increased by 24.2%, compared with the control group (3177 IU/mL). Therefore the coupling technology can effectively weaken the feedback inhibition and thus increase the yield of nisin by in situ fast removal of the product from broth during fermentation. © 2014 Curtin University of Technology and John Wiley & Sons, Ltd.
An inhibitory role for caspase‐3 at the late stage of RANKL‐induced osteoclast differentiation in RAW264 cells and mouse bone marrow macrophages
Authors: Katao Yuko , Shishido Mika , Inami Kaoru , Matsumoto Naoyuki , Sawai Hirofumi 
Published: February 2014

AbstractOsteoclast differentiation/activation is involved in orthodontic tooth movement at the compression sites of the alveolar bone. RANKL, a member of the TNF family expressed in osteoblasts, binds to RANK, a member of the TNF receptor family expressed on preosteoclasts, resulting in differentiation of preosteoclasts into mature osteoclasts. Several members of the TNF family, such as TNF and Fas ligand, can induce apoptosis by activation of caspase‐3. We have investigated whether caspase‐3 be involved in the late stage of RANKL‐induced osteoclast differentiation. Increased active caspase‐3 was found in mouse monocytic RAW264 cells differentiated into mature osteoclasts by treatment with RANKL for 3 days. Co‐treatment with Z‐Asp‐CH2‐DCB, a caspase‐3‐specific inhibitor, augmented RANKL‐induced osteoclast differentiation in RAW264 cells, also seen in mouse bone marrow macrophages. This suggests that activation of caspase‐3 may play an inhibitory role at the late stage of RANKL‐induced osteoclast differentiation.
Thrombin promotes proliferation of human lung fibroblasts via protease activated receptor‐1‐dependent and NF‐κB‐independent pathways
Authors: Zhou Shengyu , Xiao Wei , Pan Xiujie , Zhu Maoxiang , Yang Zhihua , Zhang Fayan , Zheng Chunyan 
Published: February 2014

AbstractAcute and chronic respiratory diseases are associated with abnormal coagulation regulation and fibrolysis. However, the detailed mechanism by which coagulation regulation and fibrolysis affect the occurrence and development of lung diseases remain to be elucidated. Protease activated receptor‐1 (PAR‐1), a major high‐affinity thrombin receptor, and nuclear factor kappa B (NF‐κB), a transcription factor, are involved in cell survival, differentiation, and proliferation. We have investigated the potential mechanism of thrombin‐induced fibroblast proliferation and roles of PAR‐1 and NF‐κB signalling in this process. The effect of thrombin on proliferation of human pulmonary fibroblasts (HPF) was assessed by 5‐bromo‐2‐deoxyuridine (BrdU) incorporation assay. The expression of PAR1 and NF‐κB subunit p65 protein was detected by Western blot. Nuclear translocation of p65 was examined by laser scanning confocal microscopy. We show that thrombin significantly increased proliferation of HPF as determined by induction of BrdU‐positive incorporation ratio. Induced PAR1 protein expression was also seen in HPF cells treated with thrombin. However, thrombin had no significant effect on expression and translocation of NF‐κB p65 in HPF cells. The results indicate that, by increasing protein expression and interacting with PAR1, thrombin promotes HPF proliferation. NF‐κB signalling appears to play no role in this process.
A novel verifiable secret sharing mechanism using theory of numbers and a method for sharing secrets
Authors: Liu Yanjun , Harn Lein , Chang Chin‐Chen 
Published: February 2014

SummaryVerifiable secret sharing (VSS) has been extensively used as a cryptographic tool in many applications of information security in recent years. A VSS enables a dealer to divide a secret s into n shares and allows shareholders to verify whether their shares are generated by the dealer consistently without revealing the secrecy of both shares and the secret. More specifically, shareholders can verify that (i) the secret can be recovered by any t or more than t shares and (ii) the secret cannot be obtained by fewer than t shares. Many VSSs are based on polynomial, and only a few of them are based on the Chinese Remainder Theorem (CRT). Recently, Harn et al. proposed a CRT‐based VSS in which multiple verification secrets are used during the phase of verification. In this paper, we propose a VSS based on Asmuth‐Bloom's (t, n) SS scheme, which depends on the CRT. Our proposed VSS is simpler and more efficient than the scheme of Harn et al. Our proposed VSS is unconditionally secure. Copyright © 2014 John Wiley & Sons, Ltd.
Modeling and measurement of cross‐talk transmission between coupled lines
Authors: Sabolić Dubravko 
Published: February 2014

SummaryIn multiwire cables, high‐frequency signals can, and do, propagate not only by direct conduction over a pair of wires the signal was inserted to but also by electromagnetic coupling between adjacent transmission lines formed out of multiple wire pairs, too. Thus, it is useful to be able to measure relevant parameters, dependent of cable geometry and isolation material, that would enable modeling of cross‐talk propagation. In this article, signal propagation between ports of two coupled lines is first theoretically analyzed using z‐parameters. Then, the physical quantities needed for calculation of z‐parameters in systems with electrically long cable sections were defined and measured, and the results were verified against measurements performed on real cables. Copyright © 2014 John Wiley & Sons, Ltd.
Alternative reproductive tactics and sex‐biased gene expression: the study of the bulb mite transcriptome
Authors: Stuglik Michal T. , Babik Wiesław , Prokop Zofia , Radwan Jacek 
Published: February 2014

AbstractThe sexes experience different selective pressures, which can lead to highly divergent phenotypes that are achieved via sex‐biased gene expression. The effect of sexual dimorphism on the degree of sex‐bias in gene expression can be studied in species characterized by sexually selected alternative male phenotypes. We analyzed gene expression in the bulb mite Rhizoglyphus robini (Acari, Acaridae), in which more sexually dimorphic, aggressive fighter males, possessing thickened legs of the third pair which are used to kill rivals, coexist with unarmored scrambler males. We sequenced transcriptomes of adult females and both types of males and de‐novo assembled 114,456 transcriptome‐based gene models (TGMs). Significantly more TGMs had male‐biased expression than female‐biased expression. Among TGMs that were over expressed in one, but not both, male morphs (compared to expression in females), we found about four times more fighter‐biased genes than scrambler‐biased genes. This demonstrates that the degree of expression bias reflects the degree of sexually selected dimorphism. However, the number of sex‐biased genes was much higher than the number of genes differentially expressed between male morphs, and most male‐biased genes were shared between morphs, suggesting that selection pressures act similarly on males irrespective of their morph. Furthermore, we found that male‐biased genes evolved at a faster rate than female‐biased genes, as evidenced by a higher rate of both gene‐turnover and amino acid substitution, indicating that sexual selection, acting more strongly on males, accelerates the rate of molecular evolution. Interestingly, gene turnover was relatively higher, but amino acid substitution rate relatively lower among fighter‐biased genes, suggesting that different components of sexual selection may have different effects on the evolution of sex‐biased genes.
Facile Synthesis of Multipodal MnO Nanocrystals and Their Catalytic Performance
Authors: Kim Aram , Shin Dongwoo , Kim Mijong , Yoon Chohye , Song Hyunjoon , Park Kang Hyun 
Published: February 2014

AbstractMultipodal manganese oxide nanocrystals, synthesized through the thermal decomposition of a Mn‐oleate complex, exhibited catalytic activity for the synthesis of a quinoxaline derivative from a α‐hydroxy ketone with a 1,2‐diamine. The MnO nanocrystals are single crystalline and uniform multipodal, with an average estimated distance of (47 ± 2) nm between the tips of two pods.
Metal‐Free Synthesis of Cyclic and Acyclic Carbonates from CO2 and Alcohols
Authors: Lim Yu Na , Lee Chan , Jang Hye‐Young 
Published: February 2014

AbstractDiverse cyclic and acyclic carbonates such as ethylene carbonate, propylene carbonate, glycerol carbonate, and dimethyl carbonate were synthesized in moderate to good yields by the direct coupling of the corresponding alcohols with carbon dioxide in the absence of metal catalysts and inorganic bases. The direct carbonation mechanism of alcohols in the presence of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene, 1‐butyl‐3‐methylimidazolium hexafluorophosphate, and dibromomethane was probed by 18O‐labeling experiments and chiral alcohol experiments.