bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Associated with Usage of Oral-PrEP among Female Sex Workers in Nairobi, Kenya, Assessed by Self-Report and a Point-of-Care Urine Tenofovir Immunoassay
Authors: Shah Pooja , Spinelli Matthew , Irungu Erastus , Kabuti Rhoda , Ngurukiri Pauline , Babu Hellen , Kungu Mary , Champions The Maisha Fiti Study , Nyabuto Chrispo , Mahero Anne , Devries Karen , Kyegombe Nambusi , Medley Graham F. , Gafos Mitzy , Seeley Janet , Weiss Helen A. , Kaul Rupert , Gandhi Monica , Beattie Tara S. , Kimani Joshua 
Published: August 2024

AbstractPre-exposure prophylaxis (PrEP) is highly effective at reducing HIV acquisition. We aimed to estimate usage of oral-PrEP, and factors associated with adherence among female sex workers (FSWs) in Nairobi, Kenya, using a novel point-of-care urine tenofovir lateral flow assay (LFA). The Maisha Fiti study randomly selected FSWs from Sex Worker Outreach Program clinics in Nairobi. Data were collected from 1003 FSWs from June-October 2019, including surveys on self-reported oral-PrEP adherence. Adherence was also measured using the LFA for HIV-negative FSWs currently taking oral-PrEP. Informed by a social-ecological theoretical framework, we used hierarchical multivariable logistic regression models to estimate associations between individual, interpersonal/community, and structural/institutional-level factors and either self-reported or LFA-assessed adherence. Overall, 746 HIV-negative FSWs aged 18–40 participated in the study, of whom 180 (24.1%) self-reported currently taking oral-PrEP. Of these, 56 (31.1%) were adherent to oral-PrEP as measured by LFA. In the multivariable analyses, associations with currently taking oral-PrEP included having completed secondary education, high alcohol/substance use, feeling empowered to use PrEP, current intimate partner, no recent intimate partner violence, having support from sex worker organisations, experiencing sex work-related stigma, and seeking healthcare services despite stigma. Associations with oral-PrEP LFA-measured adherence measured included having only primary education, experience of childhood emotional violence, belonging to a higher wealth tertile, and being nulliparous. Oral-PrEP adherence, measured by self-report or objectively, is low among FSWs in Nairobi. Programs to improve oral-PrEP usage among FSWs should work to mitigate social and structural barriers and involve collaboration between FSWs, healthcare providers and policymakers.
Should one (be allowed to) replace the Cipollini’s?
Authors: Ausloos Marcel 
Published: August 2024

AbstractOne examines and discusses proposals on whether riders could be replaced in a team during multi-stage races, and how much a team final time at the end of the race would change (be "adjusted") if only the riders having completed the race are taken into account for ranking teams. A few results of the two main multi-stage races, the men Tour de France and the Giro d’Italia, are used as case studies. The impact of disqualification later on, due to doping, much after the end of such a race, is also examined in the case of two Tour de France. The statistical discussion is based on the Kendall-$$\tau $$τcoefficients for comparing team ranks at the end of these multi-stages races cases. One observes that there are significant differences in the results of the discussed measures. It is shown that there is much variety in results significance, whence demonstrating many interests of the "adjusted indicators". Moreover, it is argued that the "adjusted" rank indicator would promote more competitive and more attractive daily stages and lead to more valuable race management.
Screening persistent organic pollutants for effects on testosterone and estrogen synthesis at human-relevant concentrations using H295R cells in 96-well plates
Authors: Strand Denise , Nylander Erik , Höglund Andrey , Lundgren Bo , Martin Jonathan W. , Karlsson Oskar 
Published: August 2024

AbstractMany persistent organic pollutants (POPs) are suspected endocrine disruptors and it is important to investigate their effects at low concentrations relevant to human exposure. Here, the OECD test guideline #456 steroidogenesis assay was downscaled to a 96-well microplate format to screen 24 POPs for their effects on viability, and testosterone and estradiol synthesis using the human adrenocortical cell line H295R. The compounds (six polyfluoroalkyl substances, five organochlorine pesticides, ten polychlorinated biphenyls and three polybrominated diphenyl ethers) were tested at human-relevant levels (1 nM to 10 µM). Increased estradiol synthesis, above the OECD guideline threshold of 1.5-fold solvent control, was shown after exposure to 10 µM PCB-156 (153%) and PCB-180 (196%). Interestingly, the base hormone synthesis varied depending on the cell batch. An alternative data analysis using a linear mixed-effects model that include multiple independent experiments and considers batch-dependent variation was therefore applied. This approach revealed small but statistically significant effects on estradiol or testosterone synthesis for 17 compounds. Increased testosterone levels were demonstrated even at 1 nM for PCB-74 (18%), PCB-99 (29%), PCB-118 (16%), PCB-138 (19%), PCB-180 (22%), and PBDE-153 (21%). The MTT assay revealed significant effects on cell viability after exposure to 1 nM of perfluoroundecanoic acid (12%), 3 nM PBDE-153 (9%), and 10 µM of PCB-156 (6%). This shows that some POPs can interfere with endocrine signaling at concentrations found in human blood, highlighting the need for further investigation into the toxicological mechanisms of POPs and their mixtures at low concentrations relevant to human exposure.
Graphical Abstract
Government participation in virtual negotiations: evidence from IPCC approval sessions
Authors: Bayer Patrick , Crippa Lorenzo , Hughes Hannah , Hermansen Erlend 
Published: August 2024

AbstractThe Covid-19 pandemic challenged global governance in unprecedented ways by requiring intergovernmental meetings to be held online. For the Intergovernmental Panel on Climate Change (IPCC), this meant that the intergovernmental approval of the key findings of the Sixth Assessment Report (AR6) had to be conducted virtually. In this paper, we assess how the move away from face-to-face meetings affected country participation in IPCC approval sessions. Our findings demonstrate that virtual meetings increased the size of member governments’ delegations, but this did not necessarily translate into a greater number of interventions during the approval of the Summary for Policymakers (SPM) as time zone differences reduced engagement levels significantly—particularly for countries from the Pacific, East Asian, and Latin American regions whose delegations often found themselves in IPCC meetings late at night and early in the morning. These results offer initial, empirically robust evidence about what online meetings can and cannot achieve for promoting more inclusive global governance at a time when the IPCC and other organizations reflect on the future use of virtual and hybrid meeting formats.
Urbanisation has impacted the population genetic structure of the Eurasian red squirrel in Japan within a short period of 30 years
Authors: Takahata Yu , Uchida Kenta , Kutsukake Nobuyuki , Shimamoto Tatsuki , Asari Yushin , Terai Yohey 
Published: August 2024

AbstractHuman activities often induce maladaptive effects in urban wildlife, such as increased inbreeding and decreased gene flow, consequently leading to a loss of biodiversity. Although maladaptive effects are commonly reported in urban wildlife, some wildlife species are not affected. Understanding the conditions and factors that affect the genetic structure of wildlife is crucial for its conservation in urban environments. Eurasian red squirrels Sciurus vulgaris in Obihiro City, Hokkaido, Japan, have settled in large residential lots with a high risk of vehicle collisions for approximately 30 years, raising the possibility that the urban population would be genetically isolated from nearby rural populations and may experience a rapid decrease in genetic diversity. In this study, we analysed the population structure, genetic distance, and nucleotide diversity of squirrels in the Obihiro area using genome-wide single nucleotide polymorphisms (SNPs). Principal component analysis and ADMIXTURE showed that urban and rural squirrel populations formed distinct clusters with intermediate urban and rural boundary populations. Genetic distances between the urban populations were greater than that of other pairs. Nucleotide diversities were lower in urban populations than in other populations, suggesting limited gene flow between urban and other populations, possibly due to urbanisation. The change in the genetic characteristics of urban squirrel populations during this short period demonstrates the strong impact of urbanisation. Our findings suggest that a genome-wide approach to the genetic structure of wildlife contributes to its conservation in urban environments.
The Effects of Growing Groups and Scarcity on the Use of a Common Pool Resource – a Lab-in-the-Field Experiment with Lake Victoria Fishers
Authors: Dannenberg Astrid , Klatt Charlotte , Pico Pia 
Published: August 2024

AbstractUsing a lab-in-the-field experiment with Ugandan fishers, we study if and how the use of a common pool resource changes when the resource is either scarce or abundant and when the number of users increases over time. Both resource scarcity and a growing group require users to be more constrained, that is, more cooperative, in order to maintain the resource. However, the results show that fishers do not curtail their harvesting behavior under increased pressure, leading to rapid overexploitation when scarce resources are used by a growing group. This implies a particular need for sustainable management when scarce resources are exposed to in-migration.
Distance: A 2024 re-examination
Authors: Kellerman Aharon 
Published: August 2024

AbstractDistance, a concept that continues to be relevant and rather complex, is far from being obsolete despite its diminishing role in the age of virtual space. It represents spatial separation, a notion that was first quantified in Egypt some 5,000 years ago. The evolution of distance can be traced through five distinct phases: natural (absolute and relative distances), relational (time and cost distances, distance decay, friction of distance, and distanciation), technological (extensibility, accessibility, and speed), virtual (proximity, digital, cognitive, and metaphorical distances), and optional (optional and estimated distances). These historical phases have built upon each other, leading to our contemporary experience of all distance classes depending on specific separation cases. Modern humans may overcome any distance on earth, one way or another, unless prevented from doing so by political national sovereignties.
Riemannian Newton Methods for Energy Minimization Problems of Kohn–Sham Type
Authors: Altmann R. , Peterseim D. , Stykel T. 
Published: August 2024

AbstractThis paper is devoted to the numerical solution of constrained energy minimization problems arising in computational physics and chemistry such as the Gross–Pitaevskii and Kohn–Sham models. In particular, we introduce Riemannian Newton methods on the infinite-dimensional Stiefel and Grassmann manifolds. We study the geometry of these two manifolds, its impact on the Newton algorithms, and present expressions of the Riemannian Hessians in the infinite-dimensional setting, which are suitable for variational spatial discretizations. A series of numerical experiments illustrates the performance of the methods and demonstrates their supremacy compared to other well-established schemes such as the self-consistent field iteration and gradient descent schemes.
Plastic deformation and heat-enabled structural recovery of monolithic silica aerogels
Authors: Gonthier Julien , Scoppola Ernesto , Gurlo Aleksander , Fratzl Peter , Wagermaier Wolfgang 
Published: August 2024

AbstractDrying shrinkage during ambient pressure drying of silica gels is made reversible by preventing condensation reactions of surface silanol groups via surface modification. This partial recovery of the gel volume and structure is referred to as the spring-back effect (SBE) and enables the production of monolithic silica aerogels by evaporative drying. The SBE is sometimes completed by annealing at mild temperatures. Similarities between drying-related deformations and deformations induced by mechanical stimuli suggest analogous underlying mechanisms. While the causes of drying shrinkage are relatively well-known, it remains unclear how the relaxation of the structure by drying and annealing occurs across the different length scales. Here we show a complete structural recovery of silica aerogels at the macro- and nano-scale enabled by annealing. We propose that residual deformations after drying and mechanical compression are caused by the entanglement of silica clusters that can be unraveled by annealing at 230 °C. The deformation under loading is interpreted as two different re-arrangement mechanisms for dry and annealed gels, by the sliding of the silica clusters along the loading direction and by the compression of large pores beyond the fractal structure, respectively. Our results demonstrate how the shape and structure of silica aerogels can be restored and controlled by thermal activation, broadening the various applications of these materials. We also emphasize how tuning silica gels to promote a two-step SBE by annealing can pave the way toward the production of larger monolithic aerogels by APD.
Graphical Abstract
Towards time-reduced cure cycles of epoxy resins for mass production of composites maintaining the thermo-mechanical properties
Authors: González José Antonio , Farjas Jordi , Blanco Norbert , Costa Josep , Gascons Marc , Sánchez-Rodríguez Daniel 
Published: August 2024

AbstractBecause long curing times hinder the mass manufacturing of composite products, there is a constant quest to develop shorter curing cycles that maintain material quality. The authors recently developed a curing prediction methodology for thermoset composites based on an isoconversional model, which is used in this work to shorten the curing time of real practice processes. The investigation presents two optimized cure cycles devised to reduce the curing times recommended by the resin manufacturer while assure a complete degree of cure and restricting the exothermal flow to avoid undesired overheating. The mechanical (compression, in-plane, and interlaminar shear) and physical ($$T_\mathrm{{g}}$$

T
g

, void content, and outgassing) properties of specimens extracted from panels manufactured according to recommended curing cycles and the two time-reduced cycles (up to 72% shorter) presented here, exhibited deviations of less than 4%, and always fell within the acceptable range for the most demanding of industrial sectors: aeronautics. The results support the prediction model’s feasibility to achieve more efficient and productive processes.
A Monte Carlo-based approach to reduce the cost of generating synthetic holograms for 3D computer graphics scenes
Authors: Serón Francisco , Blesa Alfonso 
Published: August 2024

AbstractSimilar to computer graphics, the digital approach of holography (Computer Genarated Holograms) inherently samples the world. Calculating CGHs needs additional phase-related calculations, elevating computational demands.These calculations can make the development time excessively long or, in the worst case, unaffordable. Our approach, Partial Monte Carlo Sampling (PMCS), calculates CGHs via Monte Carlo techniques. By varying sampling resolution and ray percentages, reasonable quality is achieved, even with fewer rays. Quality analysis employing RMSE and CC reveals that reducing ray percentages does not severely compromise image quality. Both simulated and laboratory holograms display consistent trends, showcasing improved quality with increased rays and resolution. A direct relationship is established between image quality and computational time, addressing specific needs.
Entrepreneurial STEM Education: Enhancing students’ Resourcefulness and Problem-solving Skills
Authors: Kaya-Capocci Sila , Pabuccu-Akis Aybuke , Orhan-Ozteber Nil 
Published: August 2024

Abstract
The importance of enhancing entrepreneurial STEM education has become accentuated to foster sustainable, collegial, and innovative STEM practices. The study aimed to enhance high-school students’ entrepreneurial skills, namely resourcefulness and problem-solving skills, and investigate their experiences and feelings of entrepreneurial STEM education. Three entrepreneurial STEM activities were implemented with 30 students in a private high school in Turkey. The qualitative data were collected through pre- and post-interviews and group reflective journals and analysed with content analysis. The quantitative data were collected through the Self-Control Schedule (SCS) and the Problem-Solving Scale (PS) and analysed through SPSS. The quantitative data indicated that the participants’ average SCS results increased from 117.63 to 122.40 (no significant difference) and their average PS results increased from 130.00 to 135.55 (no significant difference) following an intervention. This may be because of participants’ prior experiences or the number of participants attending the study. However, there were significant changes in the subscales of SCS and PS, showing that participants’ approach-avoidance style (PS subscale) as well as planning of behaviour and control of emotions (SCS subscales) can be enhanced by implementing entrepreneurial STEM activities. The qualitative data showed that participants started to face their problems more and try to find them different solutions rather than avoiding them. The qualitative data also pointed to the changes in participants’ capability of making connections between the subject disciplines and everyday life. Moreover, students found entrepreneurial STEM activities entertaining and helpful for improving understanding of chemistry topics. The study contributes to the field by bringing authenticity to STEM education by incorporating social and green entrepreneurship, supporting students’ entrepreneurial skill development, and helping teachers and students make connections between STEM, real-world, and public.
“Black Boxes, full of them”: Biology Teachers’ Perception of the Role of Explanatory Black Boxes in Their Classroom
Authors: Livni Alcasid Gur Arie , Haskel-Ittah Michal 
Published: August 2024

AbstractMechanistic explanations, aiming to disclose details of entities and their activities, employ the act of unpacking which, inherently and paradoxically, produces explanatory gaps—pieces of undisclosed, undetailed mechanistic information. These gaps, termed explanatory black boxes, are often perceived as counterproductive to the teaching of mechanisms, yet are integral to it, and their cognizant use is a nuanced skill. Amidst the discourse on mechanistic reasoning in science education, this paper focuses on biology teachers’ perception of explanatory black boxes and the explicit discussion of them in their classroom. Using interviews with 11 experienced high-school biology teachers, we unraveled perceived affordances and constraints in teachers’ use of black boxes in the context of challenges in teaching mechanisms. Utilizing the pedagogical content knowledge (PCK) framework, we expose a nuanced interplay of considerations related to strategies, students, curriculum alignment, assessment, and orientation toward science teaching. A constant tension existed—with considerations supporting and opposing the use of both unpacking and black boxing as teaching strategies—both within and between PCK components. In contrast, contemplating the explication of black boxes led teachers to illustrate this strategy as an intermediate one, attenuating constraints of both unpacking and black-boxing strategies while also promoting teachers’ ability to align curricular items and endorse student agency. Implications for teacher training are discussed, emphasizing the need to make teachers aware of the involvement of black boxes in mechanistic reasoning, and familiarize them with black-box explication as an intermediate strategy that can enrich their pedagogy.
Interpretation of Law as Language Game: The Game of Giving and Asking for Reasons in the Courtroom
Authors: Tvrdíková Linda 
Published: August 2024

Abstract
In this text we will focus on the interpretation of law, specifically on the question of how the meaning of legal texts is created and recreated through judicial interpretation of law. To be able to explain how this happens, we will use the philosophy of language, in particular the philosophy of the late Ludwig Wittgenstein, Wilfrid Sellars and Robert B. Brandom. In their view, language is not a tool that serves primarily and exclusively to describe a world that exists independently of us and our attitudes, but through language we co-create the world we live in. Many of the things we perceive in the world around us are accessible to us and exist because of our language.
Modelling Loans to Non-Financial Corporations in the Eurozone: A Long-Memory Approach
Authors: Caporale Guglielmo Maria , Gil-Alana Luis Alberiko , Rubino Nicola , Vilchez Inmaculada 
Published: August 2024

AbstractThis paper uses fractional integration and cointegration methods to analyze the long-run relationship between loans to non-financial corporations, real gross domestic product, real gross fixed capital formation, the cost of borrowing differential between long- and short-term rates, and a proxy for the cost of debt, securities, and equity issuance. The analysis includes four Eurozone countries, namely Germany, France, Italy, and Spain, and spans the most recent decades. More precisely, fractional integration and cointegration models are estimated to investigate the persistence of the series as well as their long-run relationships and short-run dynamics using both unrestricted and restricted specifications. The univariate results are heterogeneous, the highest degrees of integration being found in the case of loans to non-financial corporations, whilst the multivariate ones provide evidence of a single fractional cointegration vector as well as of a lower adjustment speed to the long-run equilibrium compared to previous studies in all four countries. Moreover, both the short- and long-run response of loans to exogenous shocks to real gross domestic product and the cost of borrowing differentials differs across countries because of country-specific factors.