bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Investigation Into The Concepts And Applicability Of Agent Technologies
Authors:   ,   Institute of Technology Tralee, White Anne 
Published: June 2024

The software world is one of great richness and diversity Even though the concept of software agents date back to the days of AI (Artificial Intelligence) work (1970’s) the word “Agent” is currently in vogue in the computing press and computer science communities. This thesis presents a review of the ongoing evolution of software agents, places agents in context within today’s software domain, and takes a closer look at the ongoing debate of what really constitutes an '"Agenf\ The numerous dimensions of classification are studied and an opinion of the attributes that an agent should encompass is put forward. Leading on from the classifications existing agent frameworks are compared and contrasted under key functionality characteristics. A review of agents would not be complete without a study of how agents communicate with each other and with the environment in which they reside. Therefore the syntax and semantics of the ACL (Agent Communication Language) KQML (Knowledge Query and Manipulation) are investigated. For agent technology to succeed and become widely accepted it has to adhere to certain standards. Current agent standards are inadequate but are slowly being improved by the global software community, which continues to apply and adopt them. These existing standards are inspected and the importance of the adoption of a common international standard is highlighted. Finally potential areas for application of software agents are examined and two projects that have adopted agent technology as a basis are reviewed. An implementation was developed to demonstrate the total understanding of agent technology and their application. This implementation consisted of reviewing existing agent development tools, and the development of an agent program in the chosen one. Conclusions are drawn at the end on where agent technology is heading and the obstacles it faces along the way.
Thermal conductivity of BaZrO3 and KTaO3 single crystals
Authors: Tachibana Makoto , Bourgès Cédric , Mori Takao 
Published: June 2024

Abstract
BaZrO3 and KTaO3 are two rare examples of perovskite oxides that retain the ideal cubic structure down to the lowest temperature. In this paper, we report thermal conductivity (κ) between 300 and 773 K on single crystals of these compounds. For BaZrO3, the κ of 7.5 Wm−1K−1 at 300 K is ∼40% larger than the previously reported polycrystalline values. For KTaO3, our value of 13.1 Wm−1K−1 at 300 K clarifies the sources of error in some of the previously reported data. These results underscore the importance of high-quality experimental data in benchmarking the accuracy of advanced first-principles κ calculations.
Ciências Forense: Atuação do Enfermeiro forense em desastres naturais
Authors: Buzzacaro Fernanda Caetano , Farias Wanderson Santos de , Amorim Josias Nelson Torres de , Lopes Gabriel César Dias , Silva Felipe Arruda Barbosa da , Silva Uanderson Pereira da 
Published: June 2024

Introdução: O enfermeiro forense em desastres naturais avalia ferimentos, identifica vítimas, oferece suporte psicológico, previne doenças, coopera com outras agências e documenta tudo detalhadamente, unindo enfermagem e ciências forenses para cuidado integral. Objetivo: O objetivo do estudo foi analisar o papel do enfermeiro forense em desastres naturais, destacando suas funções essenciais e cooperação interagências. Método: trata-se de uma revisão integrativa Resultados: A atuação do enfermeiro forense em desastres naturais é um tema que necessita da criação de protocolos e ferramentas específicas para estudo e aprimoramento. Conclusões: A atuação do enfermeiro forense em desastres naturais requer a atenção de todos.
Relationship between changes in the electrical axis of the heart during inspiration and the structural and functional state of the heart according to echocardiography in patients with precapillary pulmonary hypertension
Authors: Sakhnova T. A. , Blinova E. V. , Martynyuk T. V. , Belevskaya A. A. , Saidova M. A. , Drozdov D. V. 
Published: June 2024

Introduction. A deep breath causes a whole range of physiological effects that are reflected in the electrocardiogram. The purpose of the study is to assess the position of the electrical axis of the heart during deep inspiration compared to quiet breathing in patients with precapillary pulmonary hypertension and compare these data with echocardiographic characteristics of the structural and functional state of the heart. Materials and methods. The study included 40 patients with idiopathic pulmonary hypertension and 40 patients with chronic thromboembolic pulmonary hypertension. Echocardiography assessed the size of the heart chambers, systolic and diastolic function of the right and left ventricles, pulmonary artery pressure, pulmonary vascular resistance and indicators of cardiovascular coupling. Results. The values of the electrical axis of the heart during free breathing were 106° [84°; 123°], on inspiration – 89° [87°; 120°] (p = 0.68). In 50 (62.5 %) patients, during a deep inspiration, the electrical axis of the heart shifted to the left from the original one, and in 30 (37.5 %) patients – to the right. In patients with a displacement of the electrical axis of the heart to the left from the original, compared with the others, the end-diastolic size of the left ventricle, end-diastolic and end-systolic volumes of the left ventricle, stroke volume, cardiac output were statistically significantly lower, and the eccentricity index, pulmonary vascular resistance and effective aortic stiffness – significantly larger. Conclusion. In patients with precapillary pulmonary hypertension, two variants of changes of the heart electrical axis during deep inspiration were identified: a shift to the right from the original and to the left from the original. Patients with a displacement of the electrical axis to the left from the original were characterized by a significantly greater increase in pulmonary vascular resistance, a decrease in left ventricular volumes, stroke volume and cardiac output.
Russian Medical Society for Arterial Hypertension expert consensus. Arterial hypertension and adherence to antihypertensive therapy
Authors: Chazova I. E. , Solntseva T. D. , Sivakova O. A. , Ageev F. T. , Fofanova T. V. , Bragina A. E. , Trushina O. Iu. 
Published: June 2024

Despite the existing recommendations for the diagnosis and treatment of arterial hypertension, a wide selection of antihypertensive drugs, the efficacy of treatment of arterial hypertension remains low. The main cause for unsatisfactory control of arterial hypertension is patients’ non-adherence to treatment, which adversely affects the prognosis for cardiovascular complications. The first step in increasing adherence to antihypertensive therapy is to determine its level. There are various methods characterized by their accessibility and accuracy for assessing adherence. There are several categories of factors influencing the level of adherence. Identifying the cause in a subsequent patient is a significant step in reducing adherence to antihypertensive therapy. In addition, it’s necessary to use strategies to increase adherence to antihypertensive therapy, including both “simplification” of the treatment regimen and strengthening the doctor-patient interaction. The aim of this consensus is to summarize and supplement knowledge about the prevalence of adherence to antihypertensive therapy in patients with arterial hypertension, methods for assessing the level of adherence, the reasons for low adherence to the treatment of arterial hypertension and approaches to improving adherence to antihypertensive medications.
Reconstruction of Binary Black Hole Harmonics in LIGO Using Deep Learning
Authors: Chatterjee Chayan , Jani Karan 
Published: June 2024

Abstract
Gravitational-wave signals from coalescing compact binaries in the LIGO and Virgo interferometers are primarily detected by the template-based matched filtering method. While this method is optimal for stationary and Gaussian data scenarios, its sensitivity is often affected by nonstationary noise transients in the detectors. Moreover, most of the current searches do not account for the effects of precession of black hole spins and higher-order waveform harmonics, focusing solely on the leading-order quadrupolar modes. This limitation impacts our search for interesting astrophysical sources, such as intermediate-mass black hole binaries and hierarchical mergers. Here we show, for the first time, that deep learning can be used for accurate waveform reconstruction of precessing binary black hole signals with higher-order modes. This approach can also be adapted into a rapid trigger generation algorithm to enhance online searches. Our model, tested on simulated injections in real LIGO noise from the third observing run (2019–2020) achieved a high degree of overlap with injected signals. This accuracy was consistent across a wide range of black hole masses and spin configurations chosen for this study. When applied to real gravitational-wave events, our model's reconstructions achieved between 85% and 98% overlap with those obtained by Coherent WaveBurst (unmodeled) and LALInference (modeled) analyses. These results suggest that deep learning is a potent tool for analyzing signals from a diverse catalog of compact binaries.
De l’Anjou à la Bohême : le double portrait équestre de Pierre de Rohan-Gié
Authors: Alis Jeanne 
Published: June 2024

Au XIXe siècle, le château de Sychrov en Bohême du Nord devient le fief d’une branche de la famille de Rohan. Les vitres de la demeure conservent de cette période un double portrait équestre de Pierre de Rohan (1451-1513) réalisé à la demande de l’un de ses descendants le Prince Camille de Rohan (1800-1892). Précieux témoins de l’histoire de la famille, la présence de ces modèles artistiques interpelle : en effet, ceux-ci sont issus d’œuvres qui, agrémentant le château du Verger à la toute fin du Moyen Âge, disparaissent au XVIIIe siècle soit un siècle avant leur réemploi à Sychrov. Dans cet article, il s’agira de revenir sur la conception de ce vitrail et de remonter aux origines du modèle artistique employé pour faire l’histoire d’un objet disparu à travers ses copies successives.
Inflammatory Profiles Induced by Intranasal Immunization with Ricin Toxin-immune Complexes
Authors: Tolman Lindsey E , Mantis Nicholas J 
Published: June 2024

Abstract
The underlying contribution of immune complexes in modulating adaptive immunity in mucosal tissues remains poorly understood. In this report, we examined, in mice, the proinflammatory response elicited by intranasal delivery of the biothreat agent ricin toxin (RT) in association with two toxin-neutralizing mAbs, SylH3 and PB10. We previously demonstrated that ricin-immune complexes (RICs) induce the rapid onset of high-titer toxin-neutralizing Abs that persist for months. We now demonstrate that such responses are dependent on CD4+ T cell help, because treatment of mice with an anti-CD4 mAb abrogated the onset of RT-specific Abs following intranasal RICs exposure. To define the inflammatory environment associated with RIC exposure, we collected bronchoalveolar lavage fluid (BALF) and sera from mice 6, 12, and 18 h after they had received RT or RICs by the intranasal route. A 32-plex cytometric bead array revealed an inflammatory profile elicited by RT that was dominated by IL-6 (&gt;1500-fold increase in BALF) and secondarily by KC (CXCL1), G-CSF, GM-CSF, and MCP-1. RICs induced inflammatory profiles in both BALF and serum response that were similar to RT, albeit at markedly reduced levels. These results demonstrate that RICs retain the capacity to induce local and systemic inflammatory cytokines/chemokines that, in turn, may influence Ag sampling and presentation in the lung mucosa and draining lymph nodes. A better understanding of the fate of immune complexes following intranasal delivery has implications for the development of mucosal vaccines for biothreats and emerging infectious diseases.
The impact of high-altitude and cold environment on brain and heart damage in rats with hemorrhagic shock
Authors: Xu Jun , Yu Wantong , Li Ning , Li Sijie , Wang Xiaojie , Gao Chen , Liu Feng-Yong , Ji Xunming , Ren Changhong 
Published: June 2024

Abstract:

BACKGROUND:
Hemorrhagic shock (HS) causes severe organ damage, worsened by high-altitude conditions with lower oxygen and temperatures. Existing research lacks specific insights on brain and heart damage under these conditions. This study hypothesizes that high-altitude and cold (HAC) environments exacerbate HS-induced damage in the brain and heart, aiming to improve treatment strategies.

MATERIALS AND METHODS:
Twenty-four male Sprague-Dawley (SD) rats (200–250 g of weight) were randomly assigned into sham, HS + normal, HS + HAC (4,000 m), and HS + HAC (6,000 m). The HS model was established in SD rats (35% loss of total blood volume), and histopathological injuries of the brain and heart were detected using hematoxylin and eosin staining, Sirius red staining, and immunohistochemistry. Apoptosis of the brain and heart tissues was detected by terminal transferase-mediated dUTP nick end labeling (TUNEL) immunofluorescence staining. To determine the levels of tumor necrosis factor-α (TNF-α), interferon-gamma (IFN-γ), monocyte chemoattractant protein-1 (Mcp-1), BCL2-associated X (BAX), and myeloid cell leukemia-1 (Mcl-1) protein, western blotting assay was used.

RESULTS:
The HAC environment induced pathological damage to the brain and heart and aggravated the degree of cardiac fibrosis in HS rats. However, it did not cause apoptosis of the brain and heart. In addition, it upregulated TNF-α, IFN-γ, Mcp-1, and BAX protein levels, but downregulated Mcl-1 protein levels (P < 0.05).

CONCLUSIONS:
The HAC environment aggravated the degree of brain and heart damage in HS rats, which may be related to neuron nucleus pyknosis, myocardial fibrosis, and inflammatory and apoptosis activation.
Primary antiphospholipid syndrome in the elderly: Four strokes and mechanical thrombectomies until the diagnosis - A case report
Authors: Anastasiadi Anatoli , Bott Chiara , Kitterer Daniel , Roser Elke , Henkes Hans , Bäzner Hansjörg , Wolf Marc E. 
Published: June 2024

Abstract:
Antiphospholipid syndrome (APS) is known as a rare etiology of embolic ischemic stroke. In individuals below 50 years, up to 20% of strokes are associated with APS, whereas in patients >50 years, it is considered a very seldom cause of stroke. We describe the course of a 66-year-old white woman, who experienced four embolic strokes with large vessel occlusion over a period of 2 years, which were repeatedly and successfully treated by mechanical thrombectomy. Initially attributed to atrial fibrillation and treated with direct oral anticoagulants, the patient was finally diagnosed with primary APS due to isolated anti-beta 2-glycoprotein antibodies and successfully treated after several stroke recurrences. After initiation of Vitamin K antagonist therapy, no further strokes occurred. For recurrent embolic stroke despite oral anticoagulation, late-onset APS might be considered a rare etiology also in the elderly.
A bibliometric review of unilateral neglect: Trends, frontiers, and frameworks
Authors: Zhao Wanying , Ye Linlin , Cao Lei , Song Weiqun 
Published: June 2024

Abstract:

BACKGROUND:
Owing to the adverse effects of unilateral neglect (UN) on rehabilitation outcomes, fall risk, and activities of daily living, this field has gradually got considerable interest. Notwithstanding, there is presently an absence of efficient portrayals of the entire research field; hence, the motivation behind this study was to dissect and evaluate the literature published in the field of UN following stroke and other nonprogressive brain injuries to identify hotspots and trends for future research.

MATERIALS AND METHODS:
Original articles and reviews related to UN from 1970 to 2022 were retrieved from the Science Citation Index Expanded of the Web of Science Core Collection. CiteSpace, VOSviewer, and Bibliometrix software were used to observe publication fields, countries, and authors.

RESULTS:
A total of 1,202 publications were incorporated, consisting of 92% of original articles, with an overall fluctuating upward trend in the number of publications. Italy, the United Kingdom, and the United States made critical contributions, with Neuropsychologia being the most persuasive academic journal, and Bartolomeo P. ranked first in both the quantity of publications and co-citations. Keywords were divided into four clusters, and burst keyword detection demonstrated that networks and virtual reality might additionally emerge as frontiers of future development and warrant additional attention.

CONCLUSIONS:
UN is an emerging field, and this study presents the first bibliometric analysis to provide a comprehensive overview of research in the field. The insights and guidance garnered from our research on frontiers, trends, and popular topics could prove highly valuable in facilitating the rapid development of this field while informing future research directions.
The effects of stress hyperglycemia in diabetic and nondiabetic patients with large vessel occlusions undergoing mechanical thrombectomy
Authors: Kasturiarachi Brittany M. , Saeed Omar , Gachechiladze Leila , Alsbrook Diana , Singh Savdeep , Zaid Ghaida , Eswaradass Prasanna , Goyal Nitin , Elangovan Cheran , Arthur Adam S. , Alexandrov Andrei V , Krishnaiah Balaji 
Published: June 2024

Abstract:

INTRODUCTION:
Diabetes and hyperglycemia are major risk factors that can increase infarction volume and contribute to poor functional status. Our study aim was to investigate the effect of stress hyperglycemia on various safety and efficacy outcomes in patients with large vessel occlusions (LVOs) undergoing mechanical thrombectomy (MT) with or without diabetes.

METHODS:
A retrospective analysis of consecutive LVO patient data treated with MT at a Comprehensive Stroke Center in the Mid-South was conducted. Adult patients with LVO on computed tomography angiography (CTA) and treated with MT within 24 h of symptom onset were included. The primary outcome was to determine if there was an association in collateral flow or infarct size in the setting of hyperglycemia. Secondary outcomes included National Institute of Health Sciences Score (NIHSS) and Modified Rankin Score (mRS).

RESULTS:
A total of 450 patients underwent MT, out of which 433 had baseline hemoglobin A1c recorded: mean age: 64 ± 15 years, 47% women, pretreatment NIHSS median 15 points (interquartile range 10–19), 323 (75%) with good collaterals grades >2 on multiphasic CTA, 326 (75%) were non-diabetic, and 107 (25%) were diabetic. Nondiabetics with stress hyperglycemia had a tendency toward higher pre-treatment NIHSS scores (mean 17.5 ± 7.6, P = 0.02) and at 24-h (12.9 ± 9.0, P = 0.02), poor collaterals (multiphasic CTA score ≥2; 21.4% vs. 34.5%, P = 0.02), larger infarct volumes (50.7 ± 63.6 vs. 24.4 ± 33.8 cc, P < 0.0001), and had poorer functional outcomes (good mRS 0–2 47.7% vs. good mRS 0–2 36.8%) when compared to nondiabetics without stress hyperglycemia. For every 1 mg/dL increase in admission blood glucose, there was a 0.3 cc increase in infarct volume (95% confidence intervals for β =0.2–0.4; P < 0.0001) after adjusting for the final thrombolysis in cerebral infarction score.

CONCLUSIONS:
LVO patients with stress hyperglycemia without previously diagnosed diabetes had more severe strokes, developed larger infarct volumes, poorer collaterals, and had worse functional outcomes at 90 days post-MT. In addition, LVO patients with diabetes and stress hyperglycemia exhibited more passes during MT and worse functional outcomes.
Palliative Right Ventricular Outflow Tract Stenting in Tetralogy of Fallot with Severe Cyanosis: Experience from a Single Center in Southern India
Authors: Priyadarshini Bhavana , Kasturi Sowmya , Reddy Srinath N. , Mohanty Satish 
Published: June 2024

Background:
This study conducted at an Indian tertiary care hospital aimed to characterize the clinical profile of tetralogy of Fallot (ToF) patients undergoing right ventricular outflow tract (RVOT) stenting and assess their immediate postprocedural outcomes until discharge.

Methods:
In this retrospective analysis, the clinical and procedural outcomes were analyzed for 20 patients who underwent palliative stenting in the RVOT for severe cyanosis associated with ToF during 2021–2023.

Results:
The median age for the patients was 2.3 years (range 3 months–21 years), two being adults (>18 years). Fourteen (70%) patients underwent elective RVOT stent and 30% underwent emergency stenting. The most common indication of RVOT stenting was hypoplastic branch pulmonary arteries (PAs) (n = 11, 78.6%) and cyanotic spell (n = 4, 66.7%) for elective and emergency surgeries, respectively. The average improvement in SpO2 was 27.2% (95% confidence interval 23.4–31.0, P < 0.001). Six (30%) patients had complications including reperfusion injury of lungs (n = 2, 33.4%) sepsis (n = 1, 16.7%), stent embolization (n = 1, 16.7%), re-stenting (n = 1, 16.7%), transient complete heart block (n = 1, 16.7%) during the procedure, and. One child went through RVOT stent postoperative due to severe residual stenosis and child developed severe tricuspid regurgitation and succumbed to death due to culture positive sepsis with multi-organ dysfunction. Rest (n = 19, 95%) were discharged with an average 6.7 days of hospital stay.

Conclusion:
ROVT stenting is a safe and effective palliative management in ToF enhancing oxygen saturation prior to definitive surgical repair.
Troponin-I as a Prognostic Marker in Patients with Coronavirus Disease 2019: Insights from a Single-center Investigation
Authors: John Dany , Kawade Ramesh , Shelke Abhijeet B 
Published: June 2024

Background:
Troponin-I is conventionally correlated with myocardial injury, but its relevance in assessing the severity of coronavirus disease 2019 (COVID-19) and its implications for patient management remains an area of ongoing investigation. This study was designed to assess the correlation between troponin-I levels and the disease severity among patients with COVID-19.

Materials and Methods:
This retrospective study was conducted at a tertiary care center in India between April 2020 and November 2021. The patients with reverse transcription-polymerase chain reaction who tested positive for COVID-19 infection, and who underwent troponin-I examination at presentation were included in the study. A comparison of baseline clinical characteristics among patients who survived and who did not survive post-COVID-19 was done, and risk factors associated with mortality among hospitalized patients were analyzed.

Results:
A total of 1673 patients were enrolled in this study. Of these, 1431 patients survived, and 242 patients did not survive post-COVID-19. The mean age of the patients with troponin-I levels ≤0.06 ng/ml was 49.66 ± 17.88 years and that of patients with troponin-I levels >0.06 ng/ml was 60.13 ± 20.04 years. The nonsurvival rate was high in patients aged >50 years compared to the patients aged ≤50 years (81.4% vs. 18.6%; P < 0.001). The mortality rate was high in patients with troponin-I levels >0.06 ng/ml compared to the patients with troponin-I levels ≤0.06 ng/ml (51.7% vs. 48.3%; P < 0.001). Breathlessness (odds ratio [OR]: 26.901; P < 0.001), cut-off troponin-I levels (OR: 8.246; P < 0.001), and other comorbidities (OR: 8.246; P < 0.001) were independently correlated with mortality among hospitalized patients with COVID-19.

Conclusion:
This study demonstrated that elevated troponin-I level at presentation was associated with disease severity and increased mortality in patients with COVID-19.