bluuebunny/crossref_metadata_2025_split huggingface dataset:
The acute effect of commercially available pulse powders on postprandial glycaemic response in healthy young men
Authors: Anderson G. Harvey , Liu Yudan , Smith Christopher E. , Liu Ting Ting , Nunez Maria Fernanda , Mollard Rebecca C. , Luhovyy Bohdan L. 
Published: October 2014

Whole pulses (beans, peas, chickpeas and lentils) elicit low postprandial blood glucose (BG) responses in adults; however, their consumption in North America is low. One potential strategy to increase the dietary intake of pulses is the utilisation of commercial pulse powders in food products; however, it is unclear whether they retain the biological benefits observed with whole pulses. Therefore, the present study examined the effects of commercially prepared pulse powders on BG response before and after a subsequent meal in healthy young men. Overall, three randomised, within-subject experiments were conducted. In each experiment, participants received whole, puréed and powdered pulses (navy beans in Expt 1; lentils in Expt 2; chickpeas in Expt 3) and whole-wheat flour as the control. All treatments were controlled for available carbohydrate content. A fixed-energy pizza meal (50·2 kJ/kg body weight) was provided at 120 min. BG concentration was measured before (0–120 min) and after (140–200 min) the pizza meal. BG concentration peaked at 30 min in all experiments, and pulse forms did not predict their effect on BG response. Compared with the whole-wheat flour control, navy bean treatments lowered peak BG concentrations (Expt 1, P< 0·05), but not the mean BG concentration over 120 min. The mean BG concentration was lower for all lentil (Expt 2, P= 0·008) and chickpea (Expt 3, P= 0·002) treatments over 120 min. Processing pulses to powdered form does not eliminate the benefits of whole pulses on BG response, lending support to the use of pulse powders as value-added food ingredients to moderate postprandial glycaemic response.
Higher breakfast glycaemic load is associated with increased metabolic syndrome risk, including lower HDL-cholesterol concentrations and increased TAG concentrations, in adolescent girls
Authors: Nicholl Analise , du Heaume Mary , Mori Trevor A. , Beilin Lawrence J. , Oddy Wendy H. , Bremner Alexandra P. , O'Sullivan Therese A. 
Published: October 2014

Almost all previous studies examining the associations between glycaemic load (GL) and metabolic syndrome risk have used a daily GL value. The daily value does not distinguish between peaks of GL intake over the day, which may be more closely associated with the risk of the metabolic syndrome. The aim of the present study was to investigate the cross-sectional associations between daily and mealtime measures of GL and metabolic syndrome risk, including metabolic syndrome components, in adolescents. Adolescents participating in the 14-year follow-up of the Western Australian Pregnancy Cohort (Raine) Study completed 3 d food records and metabolic assessments. Breakfast GL, lunch GL, dinner GL and a score representing meal GL peaks over the day were determined in 516 adolescents. Logistic regression models were used to investigate whether GL variables were independent predictors of the metabolic syndrome in this population-based cohort (3·5 % prevalence of the metabolic syndrome). Breakfast GL was found to be predictive of the metabolic syndrome in girls (OR 1·15, 95 % CI 1·04, 1·27;P <0·01), but not in boys. Other meal GL values and daily GL were found to be not significant predictors of the metabolic syndrome. When breakfast GL was examined in relation to each of the components of the metabolic syndrome in girls, it was found to be negatively associated with fasting HDL-cholesterol concentrations (P= 0·037; β = − 0·004; 95 % CI − 0·008, − 0·002) and positively associated with fasting TAG concentrations (P= 0·008; exp(β) = 1·002; 95 % CI 1·001, 1·004). The results of the present study suggest that there may be an association between breakfast composition and metabolic syndrome components in adolescent girls. These findings support further investigation into including lower-GL foods as part of a healthy breakfast in adolescence, particularly for girls.
Effect of oligofructose supplementation on body weight in overweight and obese children: a randomised, double-blind, placebo-controlled trial
Authors: Liber Anna , Szajewska Hania 
Published: October 2014

Limited evidence suggests that the dietary inclusion of oligofructose, an inulin-type fructan with prebiotic properties, may increase satiety and, thus, reduce energy intake and body weight in overweight and obese adults. The aim of the present study was to assess the effect of oligofructose supplementation for 12 weeks on the BMI of overweight and obese children. A total of ninety-seven children aged 7–18 years who were overweight and obese (BMI >85th percentile) were randomly assigned to receive placebo (maltodextrin) or oligofructose (both at an age-dependent dose: 8 g/d for children aged 7–11 years and 15 g/d for children aged 12–18 years) for 12 weeks. Before the intervention, all children received dietetic advice and they were encouraged to engage in physical activity. The primary outcome measure was the BMI-for-age z-score difference between the groups at the end of the intervention. Data from seventy-nine (81 %) children were available for analysis. At 12 weeks, the BMI-for-age z-score difference did not differ between the experimental (n 40) and control (n 39) groups (mean difference 0·002, 95 % CI − 0·11, 0·1). There were also no significant differences between the groups with regard to any of the secondary outcomes, such as the mean BMI-for-age z-score, percentage of body weight reduction and the difference in total body fat. Adverse effects were similar in both groups. In conclusion, oligofructose supplementation for 12 weeks has no effect on body weight in overweight and obese children.
Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications
Authors: Park Dong-Wook , Schendel Amelia A. , Mikael Solomon , Brodnick Sarah K. , Richner Thomas J. , Ness Jared P. , Hayat Mohammed R. , Atry Farid , Frye Seth T. , Pashaie Ramin , Thongpang Sanitta , Ma Zhenqiang , Williams Justin C. 
Published: October 2014

AbstractNeural micro-electrode arrays that are transparent over a broad wavelength spectrum from ultraviolet to infrared could allow for simultaneous electrophysiology and optical imaging, as well as optogenetic modulation of the underlying brain tissue. The long-term biocompatibility and reliability of neural micro-electrodes also require their mechanical flexibility and compliance with soft tissues. Here we present a graphene-based, carbon-layered electrode array (CLEAR) device, which can be implanted on the brain surface in rodents for high-resolution neurophysiological recording. We characterize optical transparency of the device at >90% transmission over the ultraviolet to infrared spectrum and demonstrate its utility through optical interface experiments that use this broad spectrum transparency. These include optogenetic activation of focal cortical areas directly beneath electrodes, in vivo imaging of the cortical vasculature via fluorescence microscopy and 3D optical coherence tomography. This study demonstrates an array of interfacing abilities of the CLEAR device and its utility for neural applications.
Altered levels of serum sphingomyelin and ceramide containing distinct acyl chains in young obese adults
Authors: Hanamatsu H , Ohnishi S , Sakai S , Yuyama K , Mitsutake S , Takeda H , Hashino S , Igarashi Y 
Published: October 2014

Abstract
Objective:
Recent studies indicate that sphingolipids, sphingomyelin (SM) and ceramide (Cer) are associated with the development of metabolic syndrome. However, detailed profiles of serum sphingolipids in the pathogenesis of this syndrome are lacking. Here we have investigated the relationship between the molecular species of sphingolipids in serum and the clinical features of metabolic syndrome, such as obesity, insulin resistance, fatty liver disease and atherogenic dyslipidemia.

Subjects:
We collected serum from obese (body mass index, BMI⩾35, n=12) and control (BMI=20−22, n=11) volunteers (18−27 years old), measured the levels of molecular species of SM and Cer in the serum by liquid chromatography-mass spectrometry and analyzed the parameters for insulin resistance, liver function and lipid metabolism by biochemical blood test.

Results:
The SM C18:0 and C24:0 levels were higher, and the C20:0 and C22:0 levels tended to be higher in the obese group than in the control group. SM C18:0, C20:0, C22:0 and C24:0 significantly correlated with the parameters for obesity, insulin resistance, liver function and lipid metabolism, respectively. In addition, some Cer species tended to correlate with these parameters. However, SM species containing unsaturated acyl chains and most of the Cer species were not associated with these parameters.

Conclusions:
The present results demonstrate that the high levels of serum SM species with distinct saturated acyl chains (C18:0, C20:0, C22:0 and C24:0) closely correlate with the parameters of obesity, insulin resistance, liver function and lipid metabolism, suggesting that these SM species are associated with the development of metabolic syndrome and serve as novel biomarkers of metabolic syndrome and its associated diseases.
Autophagy inhibition sensitizes hepatocellular carcinoma to the multikinase inhibitor linifanib
Authors: Pan Hongming , Wang Zhanggui , Jiang Liming , Sui Xinbing , You Liangkun , Shou Jiawei , Jing Zhao , Xie Jiansheng , Ge Weiting , Cai Xiujun , Huang Wendong , Han Weidong 
Published: October 2014

AbstractAutophagy is a critical survival pathway for cancer cells under conditions of stress. Thus, induction of autophagy has emerged as a drug resistance mechanism. This study is to determine whether autophagy is activated by a novel multikinase inhibitor linifanib, thereby impairing the sensitivity of hepatocellular carcinoma (HCC) cells to this targeted therapy. Here, we found that linifanib induced a high level of autophagy in HCC cells, which was accompanied by suppression of phosphorylation of PDGFR-β and its downstream Akt/mTOR and Mek/Erk signaling pathways. Cell death induced by linifanib was greatly enhanced after autophagy inhibition by the pharmacological inhibitors or siRNAs against autophagy related genes, ATG5 and ATG7, in vitro. Moreover, HCQ, an FDA-approved drug used to inhibit autophagy, could significantly augment the anti-HCC effect of linifanib in a mouse xenograft model. In conclusion, linifanib can induce cytoprotective autophagy by suppression of PDGFR-β activities in HCC cells. Thus, autophagy inhibition represents a promising approach to improve the efficacy of linifanib in the treatment of HCC patients.
DOSE: an R/Bioconductor package for disease ontology semantic and enrichment analysis
Authors: Yu Guangchuang , Wang Li-Gen , Yan Guang-Rong , He Qing-Yu 
Published: October 2014

Summary: Disease ontology (DO) annotates human genes in the context of disease. DO is important annotation in translating molecular findings from high-throughput data to clinical relevance. DOSE is an R package providing semantic similarity computations among DO terms and genes which allows biologists to explore the similarities of diseases and of gene functions in disease perspective. Enrichment analyses including hypergeometric model and gene set enrichment analysis are also implemented to support discovering disease associations of high-throughput biological data. This allows biologists to verify disease relevance in a biological experiment and identify unexpected disease associations. Comparison among gene clusters is also supported.
Availability and implementation: DOSE is released under Artistic-2.0 License. The source code and documents are freely available through Bioconductor (http://www.bioconductor.org/packages/release/bioc/html/DOSE.html).
Supplementary information: Supplementary Data are available at Bioinformatics online.
Contact: gcyu@connect.hku.hk or tqyhe@jnu.edu.cn
Has Sverdrup's critical depth hypothesis been tested? Mixed layers vs. turbulent layers
Authors: Franks Peter J. S. 
Published: October 2014

AbstractSverdrup (1953. On conditions for the vernal blooming of phytoplankton. Journal du Conseil International pour l'Exploration de la Mer, 18: 287–295) was quite careful in formulating his critical depth hypothesis, specifying a “thoroughly mixed top layer” with mixing “strong enough to distribute the plankton organisms evenly through the layer”. With a few notable exceptions, most subsequent tests of the critical depth hypothesis have ignored those assumptions, using estimates of a hydrographically defined mixed-layer depth as a proxy for the actual turbulence-driven movement of the phytoplankton. However, a closer examination of the sources of turbulence and stratification in turbulent layers shows that active turbulence is highly variable over time scales of hours, vertical scales of metres, and horizontal scales of kilometres. Furthermore, the mixed layer as defined by temperature or density gradients is a poor indicator of the depth or intensity of active turbulence. Without time series of coincident, in situ measurements of turbulence and phytoplankton rates, it is not possible to properly test Sverdrup's critical depth hypothesis.
Evolving readiness index for overhauling the retailing sector through retailing process reengineering implementation
Authors: S. Padhi Sidhartha , K. Jena Sarat , Zanger Ingmar , Kapil Kanwal 
Published: October 2014

Purpose– The purpose of this paper is to examine the state of readiness of the Indian retailing sector for the implementation of mobile retailing applications. It also identifies the most critical success factors (CSFs) for mobile retailing implementation through retailing process reengineering (RPR) framework.Design/methodology/approach– This paper attempts to identify a few CSFs through questionnaire survey and interview, subsequently establishing the inter-factor relationships through interpretive structural modeling framework and computing the priority weights of the interrelated factors using analytic network process. Finally, the authors compute the retailers’ RPR implementation readiness indices for mobile retailing using Multi-Level data envelopment analysis methodology.Findings– The 11 CSFs have been identified. Out of these, two factors namely Strategic Alignment and Management Control and Quality Contribute profoundly for mobile retailing implementation. Finally, a readiness index has been computed for implementation of mobile retailing in the selected retail outlets through RPR framework.Research limitations/implications– Only a few selected large retail outlets have been considered in this study and the sample size was modest. This study only revolves around the Indian retail sector.Practical implications– This study can be used as a decision support system for mobile retailing implementation in Indian retail sector. Moreover, based on the results of this study, a few retail outlets are completely ready for mobile retailing implementation. Apart from them, the other retail outlets can improve their readiness index by emphasizing on performance scores of the CSFs.Originality/value– Due to the scanty literature on mobile retailing, this study contributes to the mobile retailing body of literature in three ways: first, identification of CSFs in mobile retailing; second, interrelationship among the factors; and third, proposes a rational framework to compute retail outlets’ readiness indices for the implementation of mobile retailing through RPR framework.
Can Bharat Bazar sustain its growth? The story of an Indian retail giant
Authors: Goswami Susobham , Nath Vikas 
Published: October 2014

Subject area
The subject area is retailing in the Indian business context.

Study level/applicability
The case is suitable for an MBA course on retail marketing. Positioning is that of an advanced elective, trying to educate, apply and synthesize the facets of learning, thinking and assimilating concepts with practicalities.

Case overview
The case elucidates the trials and tribulations of Bharat Bazar, one of the top contenders in the Indian retail scene. It explores the journey of brand making and customer patronage. Under consideration is a set of options for the retailer's next stage of growth. While the decisions are not to be mutually exclusive, it is clear that the firm has neither the capacity to scale up without proper locations nor unlimited management resources for economic viability. The retailer naturally has to choose the best direction possible and dedicate all efforts to bring the firm to the next level of growth. The strategy has to be robust in any case.

Expected learning outcomes
The case will help students to: appreciate Indian macro retail variables; analyse business decisions of a retailer based on location, merchandise, and profitability; and explore future strategy options from the growth perspective as well as a socially responsible player.

Social implications
Socially, the case is nourishing and enriching as it connotes not only a wealth creation angle, but also a green and efficient supply chain one. Retailers must cater for the choice pattern of the society, whether essential or non essential items of consumption.

Supplementary materials
Teaching notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.
Clinical decision support system (CDSS) – effects on care quality
Authors: António Ferreira Rodrigues Nogueira dos Santos Marco , Tygesen Hans , Eriksson Henrik , Herlitz Johan 
Published: October 2014

Purpose
– Despite their efficacy, some recommended therapies are underused. The purpose of this paper is to describe clinical decision support system (CDSS) development and its impact on clinical guideline adherence.

Design/methodology/approach
– A new CDSS was developed and introduced in a cardiac intensive care unit (CICU) in 2003, which provided physicians with patient-tailored reminders and permitted data export from electronic patient records into a national quality registry. To evaluate CDSS effects in the CICU, process indicators were compared to a control group using registry data. All CICUs were in the same region and only patients with acute coronary syndrome were included.

Findings
– CDSS introduction was associated with increases in guideline adherence, which ranged from 16 to 35 per cent, depending on the therapy. Statistically significant associations between guideline adherence and CDSS use remained over the five-year period after its introduction. During the same period, no relapses occurred in the intervention CICU.

Practical implications
– Guideline adherence and healthcare quality can be enhanced using CDSS. This study suggests that practitioners should turn to CDSS to improve healthcare quality.

Originality/value
– This paper describes and evaluates an intervention that successfully increased guideline adherence, which improved healthcare quality when the intervention CICU was compared to the control group.
Library and information services: impact on patient care quality
Authors: Gard Marshall Joanne , Craft Morgan Jennifer , A. Thompson Cheryl , L. Wells Amber 
Published: October 2014

Purpose
– The purpose of this paper is to explore library and information service impact on patient care quality.

Design/methodology/approach
– A large-scale critical incident survey of physicians and residents at 56 library sites serving 118 hospitals in the USA and Canada. Respondents were asked to base their answers on a recent incident in which they had used library resources to search for information related to a specific clinical case.

Findings
– Of 4,520 respondents, 75 percent said that they definitely or probably handled patient care differently using information obtained through the library. In a multivariate analysis, three summary clinical outcome measures were used as value and impact indicators: first, time saved; second, patient care changes; and third, adverse events avoided. The outcomes were examined in relation to four information access methods: first, asking librarian for assistance; second, performing search in a physical library; third, searching library's web site; or fourth, searching library resources on an institutional intranet. All library access methods had consistently positive relationships with the clinical outcomes, providing evidence that library services have a positive impact on patient care quality.

Originality/value
– Electronic collections and services provided by the library and the librarian contribute to patient care quality.
Business value of in-memory technology – multiple-case study insights
Authors: Bärenfänger Rieke , Otto Boris , Österle Hubert 
Published: October 2014

Purpose
– The purpose of this paper is to assess the business value of in-memory computing (IMC) technology by analyzing its organizational impact in different application scenarios.

Design/methodology/approach
– This research applies a multiple-case study methodology analyzing five cases of IMC application scenarios in five large European industrial and service-sector companies.

Findings
– Results show that IMC can deliver business value in various applications ranging from advanced analytic insights to support of real-time processes. This enables higher-level organizational advantages like data-driven decision making, superior transparency of operations, and experience with Big Data technology. The findings are summarized in a business value generation model which captures the business benefits along with preceding enabling changes in the organizational environment.

Practical implications
– Results aid managers in identifying different application scenarios where IMC technology may generate value for their organizations from business and IT management perspectives. The research also sheds light on the socio-technical factors that influence the likelihood of success or failure of IMC initiatives.

Originality/value
– This research is among the first to model the business value creation process of in-memory technology based on insights from multiple implemented applications in different industries.