bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rare case of complete gonadal dysgenesis in a female patient with primary amenorrhea and a 46XY karyotype
Authors: Monolov Nurbek , Nurbekova Ulbolsun , Mamytova Elmira , Unusov Abdurashid , Osmonova Meerim , Makambaeva Meerim , Vityala Yethindra , Tagaev Tugolbai 
Published: August 2024

Key Clinical MessageA comprehensive diagnostic approach is crucial for patients with primary amenorrhea and short stature. Karyotyping and imaging studies help to detect hidden chromosomal abnormalities and anatomical differences, emphasizing their value in this context.AbstractA 16‐year‐old girl with absent menstruation and short stature. Further examination revealed constitutional stunting and primary amenorrhea. Karyotyping revealed a 46, XY chromosomal abnormality, whereas pelvic ultrasonography showed uterine hypoplasia and a unicornuate uterus with a rudimentary horn. After 11 months of therapy, she experienced menarche and improved secondary sexual characteristics.
Late subsequent Merkel cell carcinoma after 21 years of the first primary diagnosis: When to de‐escalate surveillance?
Authors: Borda Luis J. , Cushman Courtny S. , Pariser Robert J. 
Published: August 2024

Key Clinical MessageMerkel cell carcinoma (MCC) presents challenges in surveillance due to varied recurrence rates and uncertain follow‐up protocols, especially in late recurrent cases. These cases need personalized monitoring strategies beyond traditional timelines, such as clinical and molecular factors, in order to optimize patient outcomes.AbstractMerkel cell carcinoma (MCC) is a rare, aggressive skin cancer with neuroendocrine differentiation with a propensity for recurrence following initial treatment. Surveillance strategies for MCC patients lack specificity, and the duration of surveillance remains uncertain, posing challenges in identifying appropriate follow‐up intervals. Therefore, we present a 94‐year‐old woman, with history of stage IA MCC in her left nasal wall 21 years prior, that presented with a dome‐shaped eroded nodule on her left fifth finger. Biopsy showed characteristic MCC features with positive immunohistochemistry for CD56, synaptophysin, and CK20 (perinuclear dotting). The patient opted against further imaging or lymph node biopsy and underwent Mohs micrographic surgery. To date, there has not been any evidence of recurrence at previous sites or development of new primary lesions. This case underscores the need for ongoing surveillance despite long disease‐free intervals. It also stands out as the case demonstrating the longest latency/recurrence‐free interval following the initial diagnosis of MCC in the literature. While most recurrences occur within the first few years post‐diagnosis, our case highlights the exceptional nature of late recurrences and prompts reevaluation of surveillance protocols. Current guidelines recommend surveillance for up to 3 years post‐treatment, but factors, such as patient demographics and tumor characteristics, may warrant extended monitoring periods. Emerging biomarkers, such as Merkel cell polyomavirus status and circulating tumor DNA, show promise in predicting and monitoring recurrences, but their utility in late recurrence detection requires further investigation.
N2O Assisted Ethane Transformation into Ethylene Using NiO−CeO2−ZrO2 Catalysts
Authors: Sánchez Ginebra , Dejoz Ana M. , Fernández‐Domene Ramón , Barroso‐Martín Isabel , Ballesteros‐Plata Daniel , Infantes‐Molina Antonia , Cecilia Juan A. , Rodríguez‐Castellón Enrique , López Nieto José M. , Sánchez‐Tovar Rita , Solsona Benjamín 
Published: August 2024

AbstractNiO−CeO2 and NiO−CeO2−ZrO2 catalysts have been synthesized, electrochemically characterized (Mott‐Schottky (MS) measurements and Electrochemical Impedance Spectroscopy), physicochemically characterized (by N2 adsorption, XRD, Transmission Electron Microscopy and XPS) and tested in the N2O assisted ethane oxydehydrogenation. The use of low Zr‐loadings (Zr/Ce=0.1 at. ratio) has led to the optimal results in the ethylene production, improving those obtained by the Zr‐free NiO−CeO2 catalyst. However, high Zr‐loadings have meant a decrease in the olefin production. The catalytic results obtained have been explained considering the amount of oxygen vacancies, the crystalline phases formed and, especially, the nature of the surface Ni species. Importantly, the use of N2O as an oxidizing agent leads to a remarkable improvement in the selectivity to the olefin compared to that obtained employing molecular O2. Then, for a given ethane conversion the selectivity to ethylene is ca. 15 points higher using N2O than using O2. Another additional positive aspect of this NiO−CeO2−ZrO2 catalyst is its high catalytic stability.
Bioinspired Molecular Scalpel for Two‐Dimensional Metal‐Organic Nanosheet: Design Strategies and Recent Progress
Authors: Liu Yang , Ge Fayuan , Duan Xinde , Wu Tingting , Qin Ling , Zheng Hegen 
Published: August 2024

AbstractUltrathin two‐dimensional (2D) metal‐organic nanosheets (MONs) have attracted continued attention in the field of advanced functional materials. Their nanoscale thickness, high surface‐to‐volume ratio, and abundant accessible active sites, are superior advantages compared with their 3D bulk counterparts. Bioinspired molecular scalpel strategy is a promising method for the creation of 2D MONs, and may solve the current shortcomings of MONs synthesis. This review aims to provide a state‐of‐the‐art overview of molecular scalpel strategies and share the results of current development to provide a better solution for MONs synthesis. Different types of molecular scalpel strategies have been systematically summarized. Both mechanisms, advantages and limitations of multiform molecular scalpel strategies have been discussed. Besides, the challenges to be overcome and the question to be solved are also introduced.
Exposure assessment of severe acute respiratory syndrome coronavirus 2 and norovirus genogroup I/genogroup II in aerosols generated by a municipal wastewater treatment plant
Authors: Gonçalves José , Franco Andrés Felipe , Gomes da Silva Priscilla , Rodriguez Elisa , Diaz Israel , González Peña Maria José , Mesquita João R. , Muñoz Raul , Garcia‐Encina Pedro 
Published: August 2024

AbstractThe presence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in wastewater and its potential as an airborne transmission source require extensive investigation, particularly in wastewater treatment plants (WWTPs), where few studies have been conducted. The aim of this study was to investigate the presence of SARS‐CoV‐2 and norovirus (NoV) RNA in wastewater and air samples collected from a municipal WWTP. In addition, the study assessed the potential risk of viral exposure among WWTP employees. In both the summer and winter campaigns of this study, SARS‐CoV‐2 and NoV RNA were quantified in wastewater/sludge samples other than effluent. Viral RNA was not detected in any of the air samples collected. The exposure risk assessment with the SARS‐CoV‐2 RNA concentrations in the influent pumping station of this study shows a lower risk than the calculation with the historical data provided by AquaVall, but both show a low‐to‐medium exposure risk for the WWTP workers. The sensitivity analysis shows that the result of the model is strongly influenced by the SARS‐CoV‐2 RNA quantification in the wastewater. This study underscores the need for extensive investigations into the presence and viability of SARS‐CoV‐2 in wastewater, especially as a potential airborne transmission source within WWTPs.
Factors associated with an inconclusive result from commercial homologous recombination deficiency testing in ovarian cancer
Authors: Sullivan Mackenzie W. , Graves Stephen , Adkoli Anusha , Zhou Qin , Iasonos Alexia , Ellenson Lora H. , Chi Dennis S. , Aghajanian Carol , Liu Ying L. , Sonoda Yukio , O’Cearbhaill Roisin E. , Weigelt Britta , Grisham Rachel N. 
Published: August 2024

AbstractIntroductionHomologous recombination deficiency (HRD) testing is used to determine the appropriateness of poly ADP‐ribose polymerase inhibitors for patients with epithelial ovarian cancer and no germline/somatic BRCA1/2 alterations. Myriad MyChoice CDx reports a genomic instability score (GIS) to quantify the level of HRD, with a positive score defined as ≥42. The authors sought to define factors associated with obtaining an inconclusive HRD test result.MethodsGIS was retrieved for patients at their institution with epithelial ovarian cancer without germline/somatic BRCA1/2 deleterious alterations who underwent HRD testing from April 2020–August 2023. Clinical data were abstracted from the medical record.ResultsOf 477 HRD test results identified, 57 (12%) were inconclusive. High‐grade serous ovarian cancers had higher GIS than other histologic types (median 29 vs. 21, p < .001). Most HRD cases were of high‐grade serous histology; no cases with clear cell or endometrioid histology were HRD‐positive. On univariate analysis, interval versus primary cytoreductive surgery, other specimen sources versus surgical specimens, and chemotherapy exposure were risk factors for inconclusive HRD testing. On multivariable analysis, chemotherapy exposure, and tissue source were associated with an inconclusive test result, with surgical specimens more likely to yield a conclusive result than other sources (biopsy, cytology, other). Age, stage, self‐reported race, and histology were not associated with an inconclusive result.ConclusionsSurgical tissue was more likely to yield a conclusive HRD test result versus other sources of epithelial ovarian cancer tissue acquisition. When feasible, laparoscopic biopsy before initiation of neoadjuvant chemotherapy may increase the likelihood of obtaining interpretable HRD test results.
Spectroscopic Investigation of a Ruthenium Tris‐Diimine Complex Featuring a Bioinspired Alloxazine Ligand
Authors: Hagmeyer Nina , Schwab Alexander , Mroweh Nabil , McManus Caitilin , Varghese Maneesha , Mouesca Jean‐Marie , Gambarelli Serge , Kupfer Stephan , Chavarot‐Kerlidou Murielle , Dietzek‐Ivanšić Benjamin 
Published: August 2024

AbstractMolecular charge accumulating systems that act as both, photosensitizer and electron storage unit, are of interest in the context of multielectron redox processes, e. g. in solar fuel production. To this end, the photophysical properties of RuL1, a ruthenium tris‐diimine complex with an alloxazine‐based ligand as bioinspired structural motif, were investigated. The study includes absorption, emission, resonance Raman and transient absorption spectroscopy in combination with quantum chemical simulations to determine the light‐driven reactivity of the complex. Moreover, spectroelectrochemistry was employed for an in‐depth characterization of the optical properties of the reduced complex. Finally, a photolysis experiment using triethanolamine as electron source, in conjunction with redox titrations, demonstrated that visible light irradiation triggers the formation of the doubly‐reduced singly‐protonated derivative of RuL1, where both redox equivalents are stored on the alloxazine‐based ligand.
Boosted Solar Thermochemical Low‐Temperature CO2 Splitting On Pt/CeO2 by Interface Catalysis
Authors: Zong Teng , Shen Qianqian , Han Yujia , Ruan Chongyan , Liu Shu , Wang Chaojie , Tian Ming , Li Lin , Zhu Yanyan , Wang Xiaodong 
Published: August 2024

AbstractSolar thermochemical CO2 splitting using metal oxides is considered as a promising approach to produce solar fuels since it is capable to tap abundant sunlight directly and store solar energy in the renewable fuel. It remains a grand challenge to achieve highly efficient CO2 splitting at low temperature (<800 °C) due to insufficient activation of metal oxides for CO2. Herein, the introduction of a small amount of Pt was found to be able to greatly increase the performance of CO2 splitting with the highest peak CO production rate of about 65 mL min−1 g−1, CO productivity of about 53 mL g−1, nearly 100 % CO2 conversion and long‐term stability for 0.5Pt/CeO2, which exceeded most of the state‐of‐the‐art transition metals‐based oxides even at lower temperature (700 °C). This could be attributed to the addition of Pt leading to the formation of an interface (Pt0‐Ov‐Ce3+) after CH4 reduction, which improved CO2 activation and dissociation due to beneficial breakage of C=O bond by the cooperation of Pt0 and oxygen vacancies in the interface.
s‐scheme3D/3D Bi0/BiOBr/P Doped g‐C3 N4 with Oxygen Vacancies (Ov) for Photodegradation of Pharmaceuticals: In‐situ H2O2 Production and Plasmon Induced Stability
Authors: Malefane Mope E. , Managa Muthumuni , Nkambule Thabo T. I. , Kuvarega Alex T. 
Published: August 2024

AbstractComplications accompanying photocatalyst stability and recombination of exciton charges in pollutants degradation has been addressed through the construction of heterojunctions, especially S‐scheme heterojunction with strong and distinctive redox centres. Herein, an S‐scheme BiOBr (BOR) and g‐C3N4PO4 (CNPO) catalyst (BORCNPO) with oxygen vacancy (Ov) was synthesized for levofloxacin (LVX) and oxytetracycline (OTC) photodegradation under visible light. The 3D/3D BORCNPO catalyst possessed C−O−Br bridging bonds for efficient charge transfer during the fabrication of S‐scheme heterojunction. In‐situ H2O2 formation affirmed by potassium titanium (IV) oxalate spectrophotometric method improved the mineralization ability of BORCNPO7.5 catalyst. Bi0 surface plasmon resonance (SPR) enhanced formation and involvement of ⋅O2− and the stability of the catalyst which increased reaction rate with increasing cycling experiments. XPS and radical trapping experiments supported the S‐scheme charge transfer mechanism formation with high degradation rate of LVX which was 3 times higher than OTC degradation rate. Mineralization of pollutants and their intermediates were demonstrated with florescence excitation and emission matrix (FEEM) and quadruple time of flight high performance liquid chromatography (QTOF‐HPLC). This work advances development of highly stable and efficient catalysts for photodegradation of pollutants through the formation of S‐scheme heterostructure.
Modeling, design, and performance analysis of a Y‐source DC‐DC converter under limitations of hardware and leakage inductances
Authors: Rodrigues Marcus V. M. , Santos Rafael , Oro Arenas Luis De , Marafão Fernando P. , Gonçalves Flávio A. S. 
Published: August 2024

AbstractThe widespread of renewable energy sources often requires DC‐DC power converters with higher operational flexibility and voltage gain capability. The Y‐source converter offers significant features to fill this demand, but its performance can be negatively affected by coupled‐inductor leakage inductances. This paper presents simplified models for the Y‐source DC‐DC converter (YSDC) that, although not directly including the presence of leakage inductances, offer a satisfactory description of how the converter operates in terms of its steady‐state behavior, small‐signal dynamics, and estimation of power losses. These models allow for a comprehensive analysis of how non‐ideal components in the converter affect the determination of the YSDC voltage gain and efficiency and allow one to identify the most interesting design alternatives to satisfy the current and voltage stress constraints placed on the converter power switches, thus excluding undesired converter design alternatives. Experimental results with a 280 W real converter, using coupled‐inductor with leakage inductances, present results similar to those of switched circuit simulations and the derived models, thus confirming that the simplified models present satisfactory adherence to the real converter performance over the majority extent of the maximum duty cycle.
Exploring the alignment between Australian university graduate attributes and emotional intelligence competencies
Authors: Turner Kristina , Gunasekara Asanka N. , Yuan Fung Chorng , Stough Con 
Published: August 2024

AbstractUniversities have an important role to play in developing 21st century competencies in graduates. Literature shows that Emotional Intelligence (EI) could be crucial in developing these graduate attributes. This study used an exploratory thematic analysis in which we integrate information from 40 Australian universities' websites that outline their respective vision for graduate attributes and discuss them in light of EI competencies. Our study revealed that Australian universities current graduate attributes align within eight themes: global citizenship and cultural competence, critical and creative thinking and problem‐solving, communication, ethical practice, collaboration, teamwork and leadership, lifelong learning, digital literacy and information literacy and self‐directed learning including self‐management and self‐awareness. A review of the published literature in each of these fields revealed that a well‐established alignment has been previously documented through research between each of the eight individual graduate attribute themes and EI. Therefore, we conclude that embedding discipline‐specific EI content and training in undergraduate and postgraduate courses may be an effective strategy to develop graduate attributes in students. This study was the first to examine whether developing higher education students' EI competencies would support their graduate attribute skill acquisition.
Oral Supplements and Dermatology: A Review
Authors: Reeves Rachel , Luks Emily Lebowitz 
Published: August 2024

ABSTRACTIntroductionThere is growing interest in the utility of oral supplements for improving overall health and wellness. Dietary supplements and nutraceuticals with antioxidant and anti‐inflammatory properties have gained particular attention for their potential to optimize skin health. This review summarizes evidence for the following vitamins, minerals, and natural compounds in the realm of dermatology: niacinamide, vitamin D, vitamin C, vitamin E, zinc, omega‐3 fatty acids, probiotics, polyphenols, Polypodium leucotomos, coenzyme Q10, and astaxanthin.ResultsNiacinamide and vitamins C, D, and E may all protect against UV damage. Zinc and omega‐3 fatty acids may be useful for the treatment of acne and for minimizing side effects from isotretinoin. There is convincing evidence for the utility of probiotics in complementing standard treatments for acne, psoriasis, and atopic dermatitis. Collagen supplements have demonstrated anti‐aging effects but should not be routinely recommended due to their unreliable quality. Antioxidants such as P. leucotomos, coenzyme Q10, astaxanthin, and polyphenols may play a role in anti‐aging and photoprotection.ConclusionOral supplements may play a beneficial role in skin health, namely in terms of photoprotection, anti‐aging, and inflammatory conditions such as atopic dermatitis, acne, and psoriasis. However, further high‐quality studies are needed.
Superior lesion detection on 3D FSE T1WI with magnetization transfer and CHESS preparation pulses in children with focal epilepsy: Preliminary results
Authors: Wei Xing‐Chang , Assis Zarina , Sherriff Martin , Hader Walter J. , Appendino Juan Pablo 
Published: August 2024

AbstractIn childhood drug‐resistant focal epilepsy, the identification of a magnetic resonance imaging lesion significantly affects the management and prognosis, although it is often challenging. Herein we report the preliminary results of a modified MR sequence, in which both magnetization transfer and chemical shift selective preparation pulses are added to a 3D fast spin echo T1‐weighted sequence to recognize focal cortical dysplasia. The scan time is short, and the images have expected uniform suppression of the background normal gray and white matter. We report four children with focal epilepsy, in whom the focal cortical and subcortical lesions are superiorly conspicuous on the aforementioned MR sequence compared to the high‐resolution fluid‐attenuated inversion recovery images obtained with typical epilepsy MR protocols.
Characterization of the volatile components in the processing of Citri Exocarpium Rubrum black tea based on HS‐SPME and GC/MS
Authors: Zhou Qiaoyi , Liang Dongxia , Ling Caijin , Gao Liyang , Ling Zhi 
Published: August 2024

AbstractCitri Exocarpium Rubrum black tea (CER tea) is a novel blend tea infusion combining tea and CER. Due to its potential health benefits and unique flavor, it has gained popularity among consumers. Nevertheless, the aroma characteristics and key odorants of it remain to be distinguished and cognized. The HS‐SPME and GC/MS techniques were employed to analyze the alterations in volatile constituents throughout the critical stages of CER tea production. A total of 200 chemical compounds exhibited notable disparities during the processing procedures. Among them, terpenes and esters were the most abundant compounds in CER tea, which might be the key material basis for the aroma quality of CER tea. It is worth noting that 124 metabolites were significantly increased in the kneading stage and drying stage, including benzeneacet aldehyde, trans‐nerolidol, and D‐limonene, with contained floral and fruity odors, which might be closely related to the aroma of CER tea. Monoterpenes might be important contributors to the aroma of CER tea. This study provided a theoretical basis for the quality improvement of CER tea.
Effects of chemoradiation and tongue exercise on swallow biomechanics and bolus kinematics
Authors: Schaen‐Heacock Nicole E. , Rowe Linda M. , Ciucci Michelle R. , Russell John A. 
Published: August 2024

AbstractBackgroundCommon treatments for head and neck cancer (radiation and chemotherapy) can lead to dysphagia; tongue exercise is a common intervention. This study aimed to assess swallow biomechanics and bolus kinematics using a well‐established rat model of radiation or chemoradiation treatment to the tongue base, with or without tongue exercise intervention.MethodsPre‐ and post‐treatment videofluoroscopy was conducted on 32 male Sprague–Dawley rats treated with radiation/chemoradiation and exercise/no exercise. Rats in the exercise groups completed a progressive resistance tongue training paradigm. Swallow biomechanics, bolus kinematics, jaw opening, and post‐swallow respiration were assessed.ResultsBoth treatments impacted outcome measures; the addition of exercise intervention showed benefit for some measures, particularly in rats treated with radiation, vs. chemoradiation.ConclusionsRadiation and chemoradiation can significantly affect aspects of deglutition; combined treatment may result in worse outcomes. Tongue exercise intervention can mitigate deficits; more intensive intervention may be warranted in proportion to combined treatment.