bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Drosophila Prosecretory Transcription Factor dimmed Is Dynamically Regulated in Adult Enteroendocrine Cells and Protects Against Gram-Negative Infection
Authors: Beebe Katherine , Park Dongkook , Taghert Paul H , Micchelli Craig A 
Published: May 2015

Abstract
The endocrine system employs peptide hormone signals to translate environmental changes into physiological responses. The diffuse endocrine system embedded in the gastrointestinal barrier epithelium is one of the largest and most diverse endocrine tissues. Furthermore, it is the only endocrine tissue in direct physical contact with the microbial environment of the gut lumen. However, it remains unclear how this sensory epithelium responds to specific pathogenic challenges in a dynamic and regulated manner. We demonstrate that the enteroendocrine cells of the adult Drosophila melanogaster midgut display a transient, sensitive, and systemic induction of the prosecretory factor dimmed (dimm) in response to the Gram-negative pathogen Pseudomonas entomophila (Pe). In enteroendocrine cells, dimm controls the levels of the targets Phm, dcat-4, and the peptide hormone, Allatostatin A. Finally, we identify dimm as a host factor that protects against Pe infection and controls the expression of antimicrobial peptides. We propose that dimm provides “gain” in enteroendocrine output during the adaptive response to episodic pathogen exposure.
Istállóskő revisited: Lithic artefacts and assemblages, sixty years after
Authors: Markó András 
Published: May 2015

The Istállóskő cave, one of the classical sites in Hungary was generally regarded as the only important locality of the Aurignacian culture with two discrete culture-bearing layers. The assemblages played a key role in several theories on the appearance of the Upper Palaeolithic in Europe; however, this is the first time that all the lithic artefacts found since 1912 until 1965 are studied in details.
As a result of our analysis, none of the studied lithic assemblages could be attributed to to the s. str. Aurignacian industry as the diagnostic pieces are absent. Quite atypical fragmented blades and a bifacial tool have been uncovered in the poor ‘lower ( Aurignacian I) culture-bearing layer’, which — together with the rich osseous industry, including split based points — are compared to the assemblages of the Jankovich cave (Transdanubia), the Dzeravá skála/Pálffy cave (Slovakia) and layer G1 in the Vindija cave (Croatia).
In the ‘upper (Aurignacian II) culture-bearing layer’ the few Mladec/Olschewa-type osseous artefacts were associated with Gravettian flint lithics and Middle Palaeolithic and bifacial elements made from radiolarite and felsitic porphyry. This industry is compared to those known from early Gravettian sites and the Szeleta cave.
Comparison of two real-time PCR assays for the detection of malaria parasites from hemolytic blood samples — Short communication
Authors: Hagen Ralf Matthias , Hinz Rebecca , Tannich Egbert , Frickmann Hagen 
Published: May 2015

We compared the performance of an in-house and a commercial malaria polymerase chain reaction (PCR) assay using freeze–thawed hemolytic blood samples.
A total of 116 freeze–thawed ethylenediamine tetraacetic acid (EDTA) blood samples of patients with suspicion of malaria were analyzed by an in-house as well as by a commercially available real-time PCR.
Concordant malaria negative PCR results were reported for 39 samples and malaria-positive PCR results for 67 samples. The inhouse assay further detected one case of Plasmodium falciparum infection, which was negative in the commercial assay as well as five cases of P. falciparum malaria and three cases of Plasmodium vivax malaria, which showed sample inhibition in the commercial assay. The commercial malaria assay was positive in spite of a negative in-house PCR result in one case. In all concordant results, cycle threshold values of P. falciparum-positive samples were lower in the commercial PCR than in the in-house assay.
Although Ct values of the commercial PCR kit suggest higher sensitivity in case of concordant results, it is prone to inhibition if it is applied to hemolytic freeze–thawed blood samples. The number of misidentifications was, however, identical for both real-time PCR assays.
White beam X-ray Diffraction Topography (WBXDT) Studies of Bridgman Grown CdZnTe Crystals
Authors: Babalola Stephen , Uba Samuel , Hossain Anwar , Camarda Giuseppe , James Ralph , Montgomery Trent 
Published: May 2015

ABSTRACTCZT is a semiconductor material that promises to be a good candidate for uncooled gamma radiation detectors. However, to date, we are yet to overcome the technological difficulties in production of large size, defect-free CZT crystals. The most common problem is accumulation of Tellurium precipitates as microscopic inclusions. These inclusions influence the charge collection through charge trapping and electric field distortion. We employed high energy transmission X-ray diffraction techniques to study the quality of the CdZnTe crystals grown by Bridgman Technique. Crystallinity and defects within two different growth set-ups, i.e. with and without choked seeding, were compared by imaging the crystal orientation topography with white beam X-ray diffraction topography (WBXDT). The X-ray diffraction topography results show high correlation with large-area infrared transmission images of the crystals. Grain boundaries that are highly decorated with Te inclusions are observed. Characteristic Te inclusion arrangements as a result of growth conditions are discussed. We also measured the electronic properties of the detectors fabricated from ingots grown using two Bridgman processes, and observed a reduction in electrical resistivity of choked-seeding-grown CdZnTe crystals. Our results show that although choked seeding technique holds a promise in the realization of high quality mono-crystalline CdZnTe, current growth parameters must be improved to obtain defect-free crystals. These results are helpful to attain optimal seeding process for Bridgman-growth of large single crystals of CdZnTe.
“There’s an App for That”: An Interview with Dr. Jennifer Stinson, an M-Health Expert
Authors: Napoleone Marc 
Published: May 2015

Increased adoption of smartphone technology by the general public has opened up an exciting new means by which healthcare professionals can interact with their patients [1]. The smartphone’s unique ability to combine mobile communication and computation offers a novel modality by which physicians can deliver healthcare interventions to their patients. Thus, it is no wonder that the use of smartphones in healthcare settings (so called “m-health”) has become the focus of widespread interest amongst healthcare professionals, with many smartphone-based medical applications already in widespread use amongst physicians and patients [2]. Leading the charge in this m-health revolution is Dr. Jennifer Stinson, a nurse clinician scientist based at The Hospital for Sick Children in Toronto, who aims to capitalize on the popularity of smartphones among adolescents [3]. Dr. Stinson is a pioneer in the field of m-health, creating one of the first electronic pain diaries using the Palm Tungsten PDA to help adolescents with juvenile idiopathic arthritis (JIA) related pain [4]. More recently, she has created the “Pain Squad” smartphone-based app, a multiple award-winning pain measurement tool for children and adolescents with cancer [5].I was able to speak with Dr. Stinson about her experience with m-health, her views about the future of m-health, and her advice for interested healthcare professionals and trainees who want to integrate mobile technology into their own patient care. The following is an edited version of that conversation.
Development of a mobile application, ImmunizeCA, for the management of patient immunization records: a discussion with Dr. Kumanan Wilson and Katherine Atkinson
Authors: Noel Ariana , Ranganath Nischal 
Published: May 2015

Vaccinations have “saved more lives than any other health measure” over the past 50 years [1]. Currently, patient immunization records are managed using the yellow immunization card; however, a team of researchers at the Ottawa Hospital Research Institute (OHRI) has recently created a mobile application for all operating systems, inclusive of all provinces and territories, that conveniently stores patient data for every vaccination schedule [2]. The UOJM 2014 – 2015 Editor-in-Chief Team met with Dr. Kumanan Wilson (General Internist, The Ottawa Hospital) and Katherine Atkinson (Research Coordinator, OHRI) to discuss the development of the ImmunizeCA app [3], the first national immunization app to be endorsed by the Minister of Health, Rona Ambrose [4].
Estimation of Solubility and Diffusivity of Gases in Heavy Oils by Use of Late-Time Pressure-Decay Data: An Analytical/Graphical Approach
Authors: Pacheco-Roman Francisco J. , Hejazi S. Hossein 
Published: May 2015

Summary
Solubility and diffusivity of gases in heavy oils, quantified by Henry's constant (Hij) and the diffusion coefficient (D), respectively, are essential properties for the design of recovery processes that require the injection of gas or vapor solvents into the reservoir. Data, obtained from various experimental procedures such as the pressure-decay technique (PDT), are used to estimate these two parameters. The PDT uses a pressure/volume/temperature (PVT) cell where the gas-phase pressure declines as gas diffuses into heavy oil following an early- and a late-time regime. Current approaches to analyze data from the conventional PDT are either graphical techniques based on early-time data or full numerical simulation. Early-time data, when the diffusing gas has not reached the bottom of the PVT cell, do not provide enough information to simultaneously estimate both the diffusion coefficient and Henry's constant. Hence, existing graphical procedures are limited to diffusion-coefficient estimation.
In this paper, we propose a novel graphical technique to estimate the diffusion coefficient and Henry's constant by use of the late-time data from pressure-decay experiments. Our method is derived from the modeling of gas-phase pressure decay by use of Fick's second law and gas-phase mass-balance equations. We use the integral method to provide an approximate analytical solution to the set of equations. In addition, by use of the resultant solution, we develop a simple graphical method to directly estimate both the diffusion coefficient and Henry's constant. The estimated parameters through the proposed technique for methane/bitumen and carbon dioxide/bitumen experiments are in close agreement with those reported in the literature.
Participation in Physical Play and Leisure in Children With Motor Impairments: Mixed-Methods Study to Generate Evidence for Developing an Intervention
Authors: Kolehmainen Niina , Ramsay Craig , McKee Lorna , Missiuna Cheryl , Owen Christine , Francis Jill 
Published: May 2015

BackgroundParticipation in physical play/leisure (PPP) is an important therapy goal of children with motor impairments. Evidence for interventions promoting PPP in these children is scarce. The first step is to identify modifiable, clinically meaningful predictors of PPP for targeting by interventions.ObjectiveThe study objective was to identify, in children with motor impairments, body function and structure, activity, environmental, and personal factors related to PPP and modifiable by therapists.DesignThis was a mixed-methods, intervention development study. The World Health Organization framework International Classification of Functioning, Disability and Health was used.MethodsParticipants were children (6–8 years old) with motor impairments, mobilizing independently with or without equipment and seen by physical therapists or occupational therapists in 6 regions in the United Kingdom, and their parents. Self-reported PPP was assessed with the Children's Assessment of Participation and Enjoyment. Modifiable-factor data were collected with therapists' observations, parent questionnaires, and child-friendly interviews. The Children's Assessment of Participation and Enjoyment, therapist, and parent data were analyzed using descriptive statistics and linear regression. Interview data were analyzed for emerging themes.ResultsChildren's (n=195) PPP (X=18 times per week, interquartile range=11–25) was mainly ‘recreational’ (eg, pretend play, playing with pets) rather than ‘active physical’ (eg, riding a bike/scooter). Parents (n=152) reported positive beliefs about children's PPP but various levels of family PPP. Therapists reported 23 unique impairments (eg, muscle tone), 16 activity limitations (eg, walking), and 3 personal factors (eg, child's PPP confidence). Children interviewed (n=17) reported a strong preference for active play but indicated that adults regulated their PPP. Family PPP and impairment in the child's movement-related body structures explained 18% of the variation in PPP. Family PPP explained most of the variation.LimitationsIt is likely that the study had a degree of self-selection bias, and caution must be taken in generalizing the results to children whose parents have less positive views about PPP.ConclusionsThe results converge with wider literature about the child's social context as a PPP intervention target. In addition, the results question therapists' observations in explaining PPP.
Antarctic firn compaction rates from repeat-track airborne radar data: II. Firn model evaluation
Authors: Ligtenberg S.R.M. , Medley B. , Van Den Broeke M.R. , Kuipers Munneke P. 
Published: May 2015

AbstractThe thickness and density of the Antarctic firn layer vary considerably in time and space, thereby contributing to ice-sheet volume and mass changes. Distinguishing between these mass and volume changes is important for ice-sheet mass-balance studies. Evolution of firn layer depth and density is often modeled, because direct measurements are scarce. Here we directly compare modeled firn compaction rates with observed rates obtained from repeat-track airborne radar data over a 2 year interval (2009–11) in West Antarctica. Spatially, the observed compaction rates exhibit significant variability, but when averaged to scales comparable to the model resolution (20–50 km), the measurements and model results qualitatively agree. A colder and drier period preceding the 2009 survey led to lower compaction rates during the 2009–10 interval, when compared to 2010–11, which is partly captured by the firn model. Spatially, higher compaction rates are observed and modeled in warmer regions with higher accumulation.
La protection sociale libre et volontaire, notamment mutualiste, jusqu’aux années 1930
Authors: Dreyfus Michel 
Published: May 2015

La protection sociale française a une longue histoire qui commence bien avant la Sécurité sociale. Elle s’exerce tout d’abord dans le cadre de la bienfaisance, et ce dans une logique caritative. Elle se poursuit tout au long du xix e siècle sous de multiples formes : catholique, protestante et sur un plan un peu différent, patronale. La révolution industrielle favorise également l’essor des sociétés de secours mutuels : dès lors, elles poursuivent leur progression à tel point que le mouvement mutualiste est le plus important du pays en 1914. Depuis deux décennies, l’État commence à s’investir dans la protection sociale mais il faudra attendre les lendemains de la Grande Guerre pour qu’il le fasse davantage, ce qui le conduira à engager de nouveaux rapports avec les acteurs de la protection sociale privée.
Sécurité sociale et assurances sociales : la mise en œuvre de la sécurité sociale
Authors: Laroque Pierre 
Published: May 2015

Il n’existe pas de texte qui définisse aussi bien l’origine et les buts de la sécurité sociale que la conférence prononcée par Pierre Laroque, directeur général des Assurances sociales, devant les futurs cadres de la Sécurité sociale, le 23 mars 1945 (la Seconde Guerre mondiale n’est pas finie). C’est un texte de combat qui commence par rappeler que « la sécurité sociale doit fournir à tous les hommes et à toutes les femmes en âge de travailler un emploi rémunérateur. Elle commande donc l’élimination du chômage ». La deuxième conférence a été prononcée le 15 février 1947 lors de l’inauguration des nouveaux services de la caisse primaire du département de l’Yonne. Elle permet à Pierre Laroque, directeur général de la Sécurité sociale, de montrer toute l’œuvre accomplie en moins de deux ans. Depuis les deux ordonnances des 4 et 19 octobre 1945, on a fait la réforme des mutuelles, celle des prestations familiales, de la législation des accidents du travail, de l’extension progressive aux non-salariés. Les caisses ont été mises en place, ainsi que la collaboration entre les organismes de Sécurité sociale et le corps médical, le développement de la Protection maternelle et infantile, l’équipement ou la création d’hôpitaux, le renouvellement du service social et un immense effort éducatif afin que les intéressés prennent en main la gestion de leurs propres intérêts.
La démocratie sociale dans la gestion de la Sécurité sociale de 1945 à 1994
Authors: Valat Bruno , Laroque Michel 
Published: May 2015

L’instauration d’une gestion de la Sécurité sociale contribuant à une démocratie sociale était l’une des ambitions de ses créateurs. Elle fut effectivement mise en œuvre dans ses toutes premières années, sous l’égide d’une cgt unifiée qui contribua activement à la mise en place des nouvelles caisses. La gestion par les partenaires sociaux se trouva cependant rapidement plongée dans une période de turbulences, marquée par la concurrence syndicale et la contestation patronale. Ces rapports de force ainsi que les difficultés financières ont conduit à la réforme de 1967 : suppression des élections aux conseils d’administration, paritarisme et reconcentration progressive de la gestion au niveau des nouvelles caisses nationales. La généralisation de la sécurité sociale et la compensation entre régimes soulèvent la question des modalités d’un retour à plus de participation sociale, question notamment étudiée dans le cadre des états généraux de la Sécurité sociale de 1987.
La question du financement
Authors: Ferras Benjamin , Matt Jean-Luc 
Published: May 2015

La création, en 1945, de la Sécurité sociale a conduit à la mise en œuvre d’un système de financement autonome de l’État. Cette autonomie s’est matérialisée notamment par la constitution d’une organisation financière spécifique et reposant sur des recettes affectées particulières, les cotisations sociales. Par la suite, l’évolution du mode de financement de la Sécurité sociale, du « tout cotisations » vers une part croissante de recettes fiscales affectées, a entraîné une évolution de la gouvernance financière des régimes de Sécurité sociale, avec un renforcement du rôle de pilotage de l’équilibre des régimes par l’État.
La gouvernance de la Sécurité sociale à partir du plan Juppé de 1995
Authors: Ruellan Rolande 
Published: May 2015

Le plan Juppé est une réforme majeure dans l’histoire de la Sécurité sociale. Il est intervenu dans un contexte marqué par des déficits importants, des relations conflictuelles entre l’État et les partenaires sociaux et l’adoption prochaine de la monnaie unique. Il traduit la prise de conscience de la place importante de la protection sociale au sein des finances publiques. Ses points forts sont les compétences nouvelles accordées au Parlement par la réforme constitutionnelle de 1996 créant les lois de financement de la sécurité sociale ainsi que l’organisation d’un partenariat entre l’État et les caisses nationales de Sécurité sociale au moyen de la signature de conventions d’objectifs et de gestion. De la clarification des pouvoirs qu’il opère devait résulter une responsabilisation accrue des différents acteurs au service de la maîtrise des dépenses et donc des déficits. La réforme est conçue comme l’an I d’une nouvelle ère : à cette fin, les déficits cumulés sont externalisés dans une structure de défaisance, la Caisse d’amortissement de la dette sociale, alimentée par une nouvelle contribution, la contribution de remboursement de la dette sociale. Le plan Juppé a été accusé d’opérer une étatisation de la gestion de la sécurité sociale en limitant la démocratie sociale au profit des acteurs étatiques. En fait, les mesures de gouvernance adoptées en 1996 et ultérieurement ne sont plus contestées en cette année du 70 e anniversaire de la Sécurité sociale, ce qui montre qu’elles correspondent aux enjeux actuels.
The SL(2, C) Casson Invariant for Knots and the Â-polynomial
Authors: Boden Hans U. , Curtis Cynthia L. 
Published: May 2015

AbstractIn this paper, we extend the definition of the SL(2,ℂ) Casson invariant to arbitrary knots K in integral homology 3-spheres and relate it to the m-degree of the Â-polynomial of K. We prove a product formula for the Â-polynomial of the connected sum K1#K2 of two knots in S3 and deduce additivity of the SL(2,ℂ) Casson knot invariant under connected sums for a large class of knots in S3. We also present an example of a nontrivial knot K in S3 with trivial Â-polynomial and trivial SL(2,ℂ) Casson knot invariant, showing that neither of these invariants detect the unknot.
Use of Intralesional Bleomycin for Oral Hemangioma of Sturge-Weber Syndrome
Authors: Shinde Devayani , Dabholkar Yogesh G , Saberwal Akanksha A , Velankar Haritosh Kamalakar , Shetty Adip K 
Published: May 2015

ABSTRACT
Sturge-Weber syndrome (SWS) or encephalotrigeminal angiomatosis is a rare neurocutaneous disorder characterized with vascular malformations and capillary venous angiomas involving the face, choroid of the eye and leptomeninges with port wine stain, seizures activity and mental retardation. In this paper we report a case of a patient affected by Sturge-Weber syndrome presenting with tongue hemangioma and emphasize the importance of an accurate diagnosis and management in the clinical practice.

How to cite this article
Shinde D, Dabholkar YG, Saberwal AA, Velankar HK, Shetty AK. Use of Intralesional Bleomycin for Oral Hemangioma of Sturge-Weber Syndrome. Int J Head Neck Surg 2015;6(1):17-19.
Castleman's Disease: An Orphan Lymphoproliferative Disorder
Authors: Shah Pratik Dipak , Mukherji Srijon , Chauhan Yogendra 
Published: May 2015

ABSTRACT
Castleman's disease (CD) is a rare, benign disease of unknown cause that induces reactive lymph node hyperplasia. The disease was first defined by Dr Benjamin Castleman. It is an unusual cause of a neck mass. The goal of this paper is to report a rare case of Castleman's disease at unusual site (level IB) and discuss its management.

How to cite this article
Shah PD, Chauhan Y, Mukherji s. Castleman's Disease: An Orphan Lymphoproliferative Disorder. Int J Head Neck Surg 2015;6(1):20-22.
A Giant Pleomorphic Adenoma of the Palatine Arch in a 75-Year-Old Man: A Case Report with Review of Literature
Authors: Swain Santosh Kumar , Sahu Mahesh Chandra , Tripathy Rajashree 
Published: May 2015

ABSTRACT
Pleomorphic adenoma (PA) is the most common benign tumor of the salivary glands and has both epithelial and mesenchymal tissues. It most commonly arises from the parotid or submandibular glands. Rarely, it arises from the minor salivary glands. We report here a case of pleomorphic adenoma arising from the soft palate and both sides of anterior tonsillar pillars in a 75-year-old man. This patient was presenting painless slow growing large swelling in the soft palate over 20 years causing mechanical obstruction of airway and food. The entire tumor mass was excised along with overlying mucosa.

How to cite this article
Swain SK, Sahu MC, Tripathy R. A Giant Pleomorphic Adenoma of the Palatine Arch in a 75-Year-Old Man: A Case Report with Review of Literature. Int J Head Neck Surg 2015;6(1):23-25.