bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of local extension sites on survival in locally advanced maxillary sinus cancer
Authors: Kano Satoshi , Hayashi Ryuichi , Homma Akihiro , Matsuura Kazuto , Kato Kengo , Kawabata Kazuyoshi , Monden Nobuya , Hasegawa Yasuhisa , Onitsuka Tetsuro , Fujimoto Yasushi , Iwae Shigemichi , Okami Kenji , Matsuzuka Takashi , Yoshino Kunitoshi , Fujii Masato 
Published: August 2013

AbstractBackgroundWe analyzed the effects of local extension sites on survival in patients with locally advanced maxillary sinus cancer.MethodsThe criteria for inclusion in this study were as follows: (1) previously untreated maxillary sinus cancer; (2) squamous cell carcinoma; (3) T4 disease; and (4) curative‐intent treatment. The data for 118 patients were obtained from 28 institutions across Japan and analyzed for overall survival and local control rates by local extension site.ResultsSites with a poor prognosis included the cribriform plate, dura, nasopharynx, middle cranial fossa, and cranial nerves other than V2. There was a significant correlation among these sites, except for the cranial nerves. Additionally, the hard palate was the only site that correlated with nodal involvement and showed a poor treatment outcome.ConclusionEven in cases presenting with similar T4 maxillary sinus cancer, treatment should be performed in consideration of the local extension site. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1567–1572, 2014
Experience of palliative care for patients with head and neck cancer through the eyes of next of kin: Impact of an Expert Center
Authors: Offerman Marinella P. J. , Pruyn Jean F. A. , de Boer Maarten F. , Ledeboer Quirine C. P. , van Busschbach Jan J. , Baatenburg de Jong Robert J. , van der Velden Lilly‐Ann 
Published: August 2013

AbstractBackgroundLiterature is scarce on the palliative care experiences of patients with head and neck cancer. We report our experience in this patient population after the establishment of our Expert Center.MethodsWe administered a questionnaire to 40 surviving relatives of patients with head and neck cancer after the establishment of our Expert Center and compared the results to a similar group of patients with head and neck cancer before the establishment of our Expert Center.ResultsSince the establishment of our Expert Center, we found: an improved evaluation of the psychosocial support offered; better contact between head and neck surgeons, the patients, and families; and improvement in the quantity of information in the palliative phase. Some relatives, however, reported that patients received treatment against their wishes and life was not made as comfortable as possible.ConclusionImportant aspects of palliative care, such as psychosocial support and contact between patient and surgeon, have been improved since the establishment of our Expert Center. © 2013 Wiley Periodicals, Inc. Head Neck, 36: 1459–1466, 2014
Evaluation of shoulder disability questionnaires used for the assessment of shoulder disability after neck dissection for head and neck cancer
Authors: Goldstein David P. , Ringash Jolie , Bissada Eric , Jaquet Yves , Irish Jonathan , Chepeha Douglas , Davis Aileen M. 
Published: August 2013

AbstractBackgroundSeveral questionnaires have been used to evaluate shoulder disability after neck dissection. The purpose of this study was to review these measures and highlight their strengths and weaknesses.MethodsA literature review was performed to identify measures of shoulder disability after head and neck cancer surgery. These measures were evaluated in terms of their methods of development and assessment of their psychometric properties.ResultsSeven questionnaires were identified. Several of the other questionnaires have been well developed but have not had their psychometric properties assessed in the head and neck cancer population. Each questionnaire has its strengths and weaknesses.ConclusionThe strengths and weaknesses of the shoulder disability questionnaires should be considered when deciding which questionnaire to use. Efforts should be focused on using well‐designed questionnaires that have been assessed in this patient population rather than developing or using other questionnaires. © 2013 Wiley Periodicals, Inc. Head Neck, 36: 1453–1458, 2014
Conversion of glucose to lactic acid derivatives with mesoporous Sn‐MCM‐41 and microporous titanosilicates
Authors: Murillo Beatriz , Sánchez Arantxa , Sebastián Víctor , Casado‐Coterillo Clara , de la Iglesia Oscar , López‐Ram‐ de‐Viu María P. , Téllez Carlos , Coronas Joaquín 
Published: August 2013

AbstractBACKGROUNDThe production of value‐added products from biomass has acquired increasing importance due to the high worldwide demand for chemicals and energy, uncertain petroleum availability and the necessity of finding environmentally friendly processes. This paper reports work on the synthesis of several catalysts for the conversion of glucose to methyl lactate.RESULTSA MCM‐41 type mesoporous material containing tin (Si/Sn = 55) was developed with a uniform ordered mesoporous structure, high specific surface area and high pore volume. Sn‐MCM‐41 was tested in three consecutive catalytic cycles to evaluate its reusability giving methyl lactate yields of 43%, 41% and 39%, in each cycle. The slightly reduction in activity could be explained by the reduction in the accessibility of active centers due to the adsorption of reaction products and structural changes. Microporous titanosilicates and MFI‐type zeolite ZSM‐5 showed a lower catalytic performance, but exfoliated materials gave higher yields of methyl lactate and pyruvaldehyde dimethyl acetal than their respective layered precursors.CONCLUSIONSSn‐MCM‐41 material showed good results in the conversion of glucose to methyl lactate over three catalytic cycles and exfoliated materials facilitated the access of glucose to the catalytic sites and fast desorption of products. © 2013 Society of Chemical Industry
Modeling the effects of irrigation on land surface fluxes and states over the conterminous United States: Sensitivity to input data and model parameters
Authors: Leng Guoyong , Huang Maoyi , Tang Qiuhong , Sacks William J. , Lei Huimin , Leung L. Ruby 
Published: August 2013

AbstractPrevious studies on irrigation impacts on land surface fluxes/states were mainly conducted as sensitivity experiments, with limited analysis of uncertainties from the input data and model irrigation schemes used. In this study, we calibrated and evaluated the performance of irrigation water use simulated by the Community Land Model version 4 (CLM4) against observations from agriculture census. We investigated the impacts of irrigation on land surface fluxes and states over the conterminous United States (CONUS) and explored possible directions of improvement. Specifically, we found large uncertainty in the irrigation area data from two widely used sources and CLM4 tended to produce unrealistically large temporal variations of irrigation demand for applications at the water resources region scale over CONUS. At seasonal to interannual time scales, the effects of irrigation on surface energy partitioning appeared to be large and persistent, and more pronounced in dry than wet years. Even with model calibration to yield overall good agreement with the irrigation amounts from the National Agricultural Statistics Service, differences between the two irrigation area data sets still dominate the differences in the interannual variability of land surface responses to irrigation. Our results suggest that irrigation amount simulated by CLM4 can be improved by calibrating model parameter values and accurate representation of the spatial distribution and intensity of irrigated areas. Furthermore, through a set of numerical experiments, the deficiency in the current parameterization is evaluated and a critical path forward to a realistic assessment of irrigation impacts using an earth system modeling approach is recommended.
Subcompartmentalization of extracellular extravascular space (EES) into permeability and leaky space with local arterial input function (AIF) results in improved discrimination between high‐ and low‐grade glioma using dynamic contrast‐enhanced (DCE) MRI
Authors: Sahoo Prativa , Rathore Ram K.S. , Awasthi Rishi , Roy Bhaswati , Verma Sanjay , Rathore Divya , Behari Sanjay , Husain Mazhar , Husain Nuzhat , Pandey Chandra M. , Mohakud Sudipta , Gupta Rakesh K. 
Published: August 2013

Purpose:To modify the generalized tracer kinetic model (GTKM) by introducing an additional tissue uptake leakage compartment in extracellular extravascular space (LTKM). In addition, an implicit determination of voxel‐wise local arterial input function (AIF) Cp(t) was performed to see whether these changes help in better discrimination between low‐ and high‐grade glioma using dynamic contrast‐enhanced (DCE) magnetic resonance imaging (MRI).Materials and Methods:The modified model (LTKM) was explored and fitted to the concentration–time curve C(t) of each voxel, in which the local AIF Cp(t) could be estimated by a time invariant convolution approximation based on a separately measured global AIF Ca(t). A comparative study of tracer kinetic analysis was performed on 184 glioma patients using DCE‐MRI data on 1.5T and 3T MRI systems.Results:The LTKM analysis provided more accurate pharmacokinetic parameters as evidenced by their relative constancy with respect to the length of concentration–time curve used. In addition, LTKM with local AIF resulted in improved discrimination between low‐grade and high‐grade gliomas.Conclusion:LTKM with local AIF provides more accurate estimation of physiological parameters and improves discrimination between low‐grade and high‐grade gliomas as compared with GTKM. J. Magn. Reson. Imaging 2013;38:677–688. © 2013 Wiley Periodicals, Inc.
Increased nanoparticle‐loaded exogenous macrophage migration into the brain following PDT‐induced blood–brain barrier disruption
Authors: Madsen Steen J. , Gach H. Michael , Hong Seok Jin , Uzal Francisco A. , Peng Qian , Hirschberg Henry 
Published: August 2013

AbstractBackground and ObjectivePhotodynamic therapy (PDT)‐induced disruption of the blood–brain barrier (BBB) has been investigated as a technique for the delivery of therapeutic agents to selective regions of the brain. The purpose of this study was to determine the effects of PDT on the migration of systemically administered exogenous macrophages (Ma) loaded with iron oxide nanoparticles in non‐tumor bearing rats.Materials and MethodsA control group consisting of three Sprague–Dawley rats was injected with iron oxide‐loaded rat alveolar Ma via jugular vein catheter while two animals were subjected to intracranial injection of iron oxide‐loaded Ma. PDT‐treated animals were injected with photosensitizer (AlPcS2a; 1 mg/kg i.p.) followed by light irradiation (wavelength = 670 nm; light dose = 2.5 J) 48 hours later. Light irradiation was performed through the skull. Prior to light irradiation, iron oxide‐loaded Ma were administered to each animal. Animals in all groups were imaged in a 7 Tesla (T) magnetic resonance (MR) imager to determine the extent of PDT‐induced edema and to evaluate for the presence of iron oxide nanoparticles. Animals were sacrificed 7 days post‐Ma administration and their brains analyzed for the presence of iron oxide using Perls staining.ResultsSignificant uptake of iron oxide nanoparticles by rat alveolar Ma was observed thus providing the rationale for their use as delivery vectors. Histopathological analyses failed to find evidence of iron oxide in normal rat brain. Accumulations of iron oxide‐loaded Ma were observed in both MR images and histological sections of non‐tumor bearing rat brain following PDT‐induced disruption of the BBB.ConclusionsMR imaging was shown to be useful for localizing iron‐oxide loaded Ma in rat brains. Exogenous Ma are incapable of traversing the normal BBB and therefore, the use of Ma as delivery vehicles into the brain requires selective disruption of the BBB. Lasers Surg. Med. 45:524–532, 2013. © 2013 Wiley Periodicals, Inc.
DEVELOPMENT ON MY TERMS: DEVELOPMENT CONSULTANTS AND KNOWLEDGE FOR DEVELOPMENT
Authors: Borda‐Rodriguez Alexander , Johnson Hazel 
Published: August 2013

SUMMARYConsultants are an integral component of development aid. Their involvement is based on an assumption of the transferability of knowledge to clients and beneficiaries. However, this role, its efficacy and the concept of knowledge transfer have all been questioned. Although research has shown interest in northern development consultants in recent years, detailed processes and practices of southern consultants' engagement with knowledge production are less analysed. Drawing on debates about knowledge, power and managing development interventions and on extensive fieldwork exploring a Bolivian consultancy company's assignments for northern development agencies, we analyse the ‘knowledge engagements’ between clients, consultants and beneficiaries. The results suggest a novel theorisation: knowledge engagements are shaped by power relations exercised through discourses and financial aid on one hand and shared and unshared lifeworlds and backgrounds of actors on the other. They are also characterised by collusive behaviour with the discourses and practices of aid on the part of consultants and beneficiaries, which in turn influences outcomes. Southern consultants, although aware of these issues, are in a difficult position to challenge these relationships. A greater recognition of the tensions could lead to a new role for consultants if collective action were to renegotiate their terms of engagement and aim for a new mutuality. Copyright © 2013 John Wiley & Sons, Ltd.
Syncope during resistance exercise in an individual with type 1 diabetes
Authors: Turner D , Ayles M , Gray BJ , Luzio S , Bain SC , Rees ED , West DJ , Campbell MD , Bastin L , Bracken RM 
Published: August 2013

AbstractAlthough metabolic and cardiovascular effects of resistance exercise in type 1 diabetes (T1DM) remain poorly explored, research employing type 2 diabetes suggests glycaemic and cardiovascular benefits. However, this intense exercise carries some risks.Here we describe the cardiovascular and metabolic responses of a newly diagnosed, previously sedentary T1DM individual experiencing syncope during an unaccustomed acute bout of resistance exercise.The cause of this exercise‐induced incident was attributed to inappropriate cardiovascular control and lack of habituation to accompanying acid‐base disturbances. Careful consideration of exercise intensity and progression in previously sedentary T1DM performing resistance exercise sessions is warranted. Copyright © 2013 John Wiley & Sons.
Cross‐resistance risk of the novel complex II inhibitors cyenopyrafen and cyflumetofen in resistant strains of the two‐spotted spider mite Tetranychus urticae
Authors: Khalighi Mousaalreza , Tirry Luc , Van Leeuwen Thomas 
Published: August 2013

AbstractBACKGROUNDCyflumetofen and cyenopyrafen are novel acaricides acting as complex II inhibitors. This new mode of action is extremely useful for devising efficient resistance management strategies for mite control. The authors determined the cross‐resistance risk of both compounds, using a collection of well‐characterised resistant strains of Tetranychus urticae, and also selected for cyflumetofen resistance in the laboratory.RESULTSCross‐resistance to cyflumetofen and cyenopyrafen was detected in field strains, with LC50 values exceeding the registered field dose. Synergism experiments suggested that P450 monooxygenases are involved in resistance, and that the activation mechanism of the two compounds most likely differs. Laboratory selection with cyflumetofen resulted in a highly resistant T. urticae strain that displayed negative cross‐resistance to cyenopyrafen.CONCLUSIONSThe cross‐resistance risk of cyflumetofen and cyenopyrafen documented in this study needs to be integrated in resistance management strategies, especially in regions or crops with a history of frequent acaricide applications, in order to safeguard the efficacy of these compounds with a valuable new mode of action. © 2013 Society of Chemical Industry
Search‐based testing using constraint‐based mutation
Authors: Malburg Jan , Fraser Gordon 
Published: August 2013

SUMMARYMany modern automated test generators are based on either metaheuristic search techniques or use constraint solvers. Both approaches have their advantages, but they also have specific drawbacks: Search‐based methods may get stuck in local optima and degrade when the search landscape offers no guidance; constraint‐based approaches, on the other hand, can only handle certain domains efficiently. This paper describes a method that integrates both techniques and delivers the best of both worlds. On a high‐level view, the proposed method uses a genetic algorithm to generate tests, but the twist is that during evolution, a constraint solver is used to ensure that mutated offspring efficiently explores different control flow. Experiments on 20 case study programmes show that on average the combination improves branch coverage by 28% over search‐based techniques while reducing the number of tests by 55%, and improves coverage by 13% over constraint‐based techniques while reducing the number of tests by 73%. Copyright © 2013 John Wiley & Sons, Ltd.
Effects of chlorpyrifos on the metabolome of the freshwater carp, Cyprinus Carpio
Authors: Kokushi Emiko , Uno Seiichi , Pal Sandipan , Koyama Jiro 
Published: August 2013

ABSTRACTThis study investigated the effects of waterborne chlorpyrifos with concentrations of 1 and 100 µg/L for L and H‐groups, respectively, on metabolome profiles of carp plasma using 1H‐NMR. Principal component analysis suggests that chlorpyrifos exposure firstly affected in L and H‐groups on day 2 or 4, and followed a second effect in both exposure groups on day 14. Levels of metabolites related to the energy production in the body, such as glucose, glycerol, valine, leucine, isoleucine, lactate, alanine, 3‐D‐hydroxybutyrates and acetoacetate, significantly changed by exposures of chlorpyrifos. Those results suggest that energy production was severely affected in carp. The exposure could also be highly elevated ammonia levels especially in H‐group due to severe convulsion in muscle caused by the inhibition of acetylcholinesterase activity. © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 253–260, 2015.
Preoperative Cardiac Evaluation by Dipyridamole Thallium‐201 Myocardial Perfusion Scan Provides no Benefit in Patients with Abdominal Aortic Aneurysm
Authors: Shin Sung , Kwon Tae‐Won , Cho Yong‐Pil , Lee Jong‐Young , Park Hojong , Han Youngjin 
Published: August 2013

AbstractBackgroundThe purpose of the present study was to evaluate the benefits of a preoperative dipyridamole thallium‐201 myocardial perfusion scan in patients undergoing abdominal aortic aneurysm (AAA) repair.MethodsWe retrospectively reviewed findings in a prospectively collected database of patients undergoing open or endovascular repair of AAA at the Asan Medical Center, Seoul, Korea, from January 2001 to May 2011.ResultsOf 373 patients, 11 (2.9 %) had postoperative myocardial infarction (MI), whereas 24 (6.4 %), 17 (4.6 %), 24 (6.4 %), and 8 (2.1 %) were diagnosed with myocardial ischemia, atrial fibrillation, ventricular arrhythmia, and congestive heart failure, respectively. The incidence of 30‐day cardiac‐related mortality was 1.6 % (6 of 373 patients). The preoperative variables significantly associated with postoperative cardiac events in multivariate analysis were preoperative congestive heart failure (odds ratio [OR] 8.8, 95 % confidence interval [CI] 1.36–56.73, p = 0.022), long‐acting nitrates (OR 8.1, 95 % CI 1.22–54.26, p = 0.03), and body mass index (BMI) higher than 26 (OR 3.6, 95 % CI 1.49–8.48, p = 0.004). The variables obtained from dipyridamole thallium‐201 myocardial perfusion scan were not correlates of postoperative cardiac events. The sensitivity of reversible defects for postoperative cardiac events was 14 % and the specificity was 90 %. Subgroup analyses revealed that thallium defects were not significant variables in predicting postoperative cardiac events in patients with coronary artery disease (CAD) or in no‐CAD patients.ConclusionsPreoperative dipyridamole thallium‐201 myocardial perfusion scans were ineffective in predicting postoperative cardiac complications in AAA patients. These results suggest that the routine use of these tests for preoperative screening of patients undergoing AAA repair may not be warranted.
Early-summer temperature variations over the past 563 yr inferred from tree rings in the Shaluli Mountains, southeastern Tibet Plateau
Authors: Deng Yang , Gou Xiaohua , Gao Linlin , Yang Tao , Yang Meixue 
Published: August 2013

AbstractWe developed a tree-ring chronology (AD 1446–2008) based on 75 cores from 37Abies squamataMast. trees from the Shaluli Mountains, southeastern Tibet Plateau, China, using signal-free methods, which are ideally suited to remove or reduce the distortion introduced during traditional standardization. This chronology correlates best with regional temperatures in June–July, which allowed us to develop a June–July temperature reconstruction that explained 51.2% of the variance in the instrumental record. The reconstruction showed seven cold periods and five warm periods. Cold periods were identified from AD 1472 to 1524, 1599 to 1653, 1661 to 1715, 1732 to 1828, 1837 to 1847, 1865 to 1876 and 1907 to 1926. Warm intervals occurred from AD 1446 to 1471, 1525 to 1598, 1716 to 1731, 1848 to 1864, 1877 to 1906 and 1927 to present. The reconstruction agrees well with nearby tree-ring-based temperature reconstructions. Spatial correlation analyses suggest that our reconstructions provide information on June–July temperature variability for the southeastern Tibetan Plateau and its vicinity. Spectral analyses revealed significant peaks at 2–6, 10.7, 51.2, 102.2 and 204.8 yr. The temperature variability in this area may be affected by ENSO, the Pacific Decadal Oscillation and solar activity.
Coulomb explosion of nanodroplets drives the conversion of laser energy to nuclear energy
Authors: Last Isidore , Ron Shlomo , Heidenreich Andreas , Jortner Joshua 
Published: August 2013

AbstractTheoretical–computational studies of table-top laser-driven nuclear fusion of high-energy (up to 15 MeV) deuterons with ${}^{7} \mathrm{Li} $, ${}^{6} \mathrm{Li} $, and D nuclei demonstrate the attainment of high fusion yields within a source–target reaction design. This constitutes a source of Coulomb-exploding deuterium nanodroplets driven by an ultraintense femtosecond near-infrared laser and a solid hollow cylindrical target containing the second element. The source–target reaction design attains the highest table-top fusion efficiencies (up to $4\times 1{0}^{9} ~{\mathrm{J} }^{- 1} $ per laser pulse) obtained to date. The highest conversion efficiency of laser energy to nuclear energy ($1{0}^{- 2} $–$1{0}^{- 3} )$ for table-top DD fusion attained in the source–target design is comparable to that for DT fusion currently accomplished for ‘big science’ inertial fusion setups.
Gravity-driven thin-film flow on a flexible substrate
Authors: Howell P. D. , Robinson J. , Stone H. A. 
Published: August 2013

AbstractWe study the flow of a thin liquid film along a flexible substrate. The flow is modelled using lubrication theory, assuming that gravity is the dominant driving force. The substrate is modelled as an elastic beam that deforms in two dimensions. Steady solutions are found using numerical and perturbation methods, and several different asymptotic regimes are identified. We obtain a complete characterization of how the length and stiffness of the beam and the imposed liquid flux determine the profile of the liquid film and the resulting beam deformation.