bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen
Authors: Bailón Elvira , Ugarte-Berzal Estefanía , Amigo-Jiménez Irene , Van den Steen Philippe , Opdenakker Ghislain , García-Marco José A , García-Pardo Angeles 
Published: July 2014

AbstractThis study addresses the role of (pro)MMP-9 overexpression in CLL cell migration. We have used primary CLL cells and CLL-derived MEC-1 cells transfected with empty (mock cells) or proMMP-9-encoding (MMP-9 cells) lentiviral vectors. The constitutive (pro)MMP-9 expression in mock cells and primary CLL cells was similar, whereas in MMP-9 cells, expression resembled that of CLL cells incubated with proMMP-9. In xenograft models, in NOD/SCID mice, MMP-9-MEC-1 transfectants showed significantly reduced homing to bone marrow and spleen compared with mock cells. Likewise, incubation of primary CLL cells with proMMP-9, before injection into mice, inhibited their homing to these organs. This inhibition was specific, dose-dependent, and observed in all CLL tested, independently of prognostic markers or disease stage. Additionally, the MMP-9 catalytic activity was only partially involved, as the inactive mutant proMMP-9MutE had a partial effect. MMP-9 cells also showed impaired migration in vitro, which was reverted by reducing (pro)MMP-9 expression with siRNAs. CLL migration thus requires optimal (pro)MMP-9 expression levels, below or above which migration is hampered. Biochemical analysis of the (pro)MMP-9 effect indicated that MMP-9 cells or primary CLL cells incubated with proMMP-9 had reduced activation of migration regulatory molecules, including RhoAGTPase, Akt, ERK, and FAK. In contrast, p190RhoGAP (RhoA inhibitor) and PTEN (Akt/ERK/FAK inhibitor) were up-regulated in MMP-9 cells. Reduction of (pro)MMP-9 expression by siRNAs restored RhoA activity and diminished PTEN levels. Our results reveal a novel function for (pro)MMP-9 in modulating signaling pathways leading to CLL cell arrest. Therefore, local high (pro)MMP-9 expression may contribute to malignant cell retention in lymphoid organs and disease progression.
How a Beacon Community Program in New Orleans Helped Create a Better Health Care
System By Building Relationships Before Technology
Authors: Khurshid Anjum , Brown Lisanne 
Published: July 2014

Introduction: In the aftermath of Hurricane Katrina, much of New Orleans’
healthcare infrastructure was destroyed. Initial federal funding after the storm
expanded primary care services and helped set up medical homes for New Orleans’ large
uninsured and underinsured population. Following that, the Beacon Community in New
Orleans, charged with improving health care through the use of technology, decided the
best way to accomplish those goals was to build community partnerships and introduce
technology improvements based on their input and on their terms. The purpose of this
paper is to describe how those partnerships were wrought, including the innovative use
of a conceptual framework, and how they are being sustained; how different technologies
were and are being introduced; and what the results have been so far.Methods: Past
successful community experiences, as well as a proven conceptual framework, were used to
help establish community partnerships and governance structures, as well as to
demonstrate their linkages. This paper represents a compilation of reports and
information from key Beacon leaders, staff and providers and their firsthand experiences
in setting up those structures, as well as their conclusions.Results: The community
partnerships proved extremely successful in not only devising successful ways to
introduce new technology into healthcare settings, but in sustaining those changes by
creating a governance structure that has enough fluidity to adapt to changing
circumstances.Conclusions: Building and developing community partnerships takes time and
effort; however, these relationships are necessary and essential to introducing and
sustaining new technologies in a healthcare setting and should be a first step for any
organization looking to accomplish such goals.
Study of a Cu-Al-Mn Shape Memory Alloy Produced by Plasma Melting Followed by Injection Molding
Authors: Roberto Pereira Francisco Fernando , Ferreira Coutinho Maria Goretti , Miranda Bruno Moura , de Araújo Carlos José 
Published: July 2014

ABSTRACTShape Memory Alloys (SMA) are characterized by the capacity to recover a permanent deformation after being heated above a critical temperature called Final Austenite Temperature (Af). The Ni-Ti SMA are the most commercially used, however recent studies showed that the Cu-Al-Mn SMA present significant shape recovery and mechanical properties, showing a strong potential for developing new applications. In this context, the main goal of this work is to manufacture a Cu-Al-Mn SMA through a plasma melting process followed by injection molding of liquid metal and then characterize the samples, using the following techniques: Optical Microscopy (OM), Differential Scanning Calorimetry (DSC), Electrical Resistance as a function of Temperature (ERT) tests, Dynamical Mechanical Analysis (DMA) and Microhardness (MH).
Self-Consolidating Green Concrete Based on Metakaolin and Aggregate Fines
Authors: Kuznetsova E.F. , Sobolev G.M. , Sobolev K. 
Published: July 2014

ABSTRACTThe improvement of concrete workability can provide a considerable reduction of production expenses and also leads to significant improvement of construction quality. This paper reports on the development of self-consolidating concrete (SCC) based on local materials, such as metakaolin (MK) and aggregate fines. The use of metakaolin in SCC is found to be very promising, due to its ability to increase the flowability and segregation resistance of concrete mixtures. Furthermore, due to pozzolanic properties, the application of MK provides an improvement of concrete microstructure, strength and durability. The proposed SCC design includes the optimization of aggregates and combined aggregate-binder powders to target 0.45- and 0.3- power particle size distributions, respectively.
Liquid-Droplet as a model for the rotation curve problem
Authors: Darabi Farhad 
Published: July 2014

Abstract
The dynamics of large scale gravitational structures like galaxies, local groups and clusters is studied based on the so-called Liquid-Droplet model describing the saturation property of the nuclear force. Using the assumption that the gravitational force is also saturated over large scale structures, it is argued that the Newtonian gravitational potential may be replaced by an effective Machian gravitational potential. Application of this new potential at these large scale structures may give the rotation curves in good agreement with observations. Then, the virial theorem for this kind of gravitational interaction is developed and also the Tully-Fisher relation is obtained. A physical explanation is given for the so-called constant acceleration in the MOND as the effective gravitational strength of these structures. Finally, a brief argument is given for comparison with dark matter models.
Eruption of palmoplantar pustular psoriasis in patient treated with anti-androgen therapy for prostate cancer and aggravation of lesions after statin treatment
Authors: Pietrzak Aldona , Mosiewicz Jerzy , Chodorowska Grażyna , Brzozowska Anna , Michalak-Stoma Anna , Szumiło Justyna , Trojnar Marcin , Krasowska Dorota , Wawrzycki Bartłomiej , Franciszkiewicz-Pietrzak Kinga , Polkowski Wojciech , Lotti Torello 
Published: July 2014

Abstract
The article focuses on the eruption of palmoplantar pustular psoriasis, which was documented in a 53-year-old man diagnosed with prostate cancer with bone metastases. This clinical finding was made during routine hormone therapy and palliative radiotherapy. The local improvement in skin lesions was achieved following administration of topical ointments and the use of UVA 311 nm radiation therapy. The management of prostate cancer in this subject resulted in malaise, onset of diabetes mellitus and increased concentration of serum lipids. Interestingly, a few days after the statin treatment was initiated, the intensive pustule eruption was observed as well as severe pain and burning sensation in the palms and soles. The dermatological treatment led to significant improvement. The patient is still receiving oncological therapy and is monitored by dermatologists on a regular basis.
Speech evoked auditory brainstem response in learning disabled children
Authors: Ghannoum Mohamed Tarek , Shalaby Amani Ahmed , Dabbous Abeir Osman , Abd-El-Raouf Ehab Ragaa , Abd-El-Hady Hebatallah Sherif 
Published: July 2014

Background:
Children with learning disability (LD) are thought to have deficits of neural origin. Speech evoked auditory brainstem responses (ABR) can objectively assess the biological processes underlying auditory processing of complex signals, not revealed using standard ABR responses to clicks.

Objective:
To assess central auditory processing functions in children with learning disability through electrophysiological testing.

Methods:
The present study comprised 60 normal hearing children of both genders. Cases included 30 learning disabled children and the controls included 30 healthy children without a learning disability. Each group was further subdivided into three subgroups according to age: subgroup age ranging from 6 to 8 years, > 8 to 10 years and > 10 to 12 years. All subjects were submitted to full history taking, otological examination, basic audiological evaluation, and Speech ABR testing. Parameters measured were latencies and amplitudes of the onset response and the steady state response waves.

Results:
This study showed that all subjects demonstrated identifiable and repeatable waves. The reliability of the response peaks was generally very good. All LD children showed statistically significant delayed latencies of waves V, A and F in both ears in all tested subgroups, compared to their controls. There was a statistically significant diminished amplitude of wave F in all tested subgroups in both ears compared to their controls. There was a statistically significant decreased amplitudes of waves D and E in 6–8 years subgroup and waves C and D in 8–10 years subgroup compared to their controls. In addition, compared to the controls, the amplitude of waves D and E were statistically significantly decreased in the 6-8 years subgroup, and waves C and D in the 8-10 years subgroup.

Conclusion:
Speech evoked ABR response parameters are affected in LD children, reflecting abnormalities in brainstem encoding of speech signals.
Considérations sur les phénomènes somatiques et l'autisme adulte. Une tension du 3 e Plan autisme
Authors: Diébold Lionel , Pedinielli Jean-Louis 
Published: July 2014

La séparation entre organisme et vivant tend à révéler les deux médecines qui s’opposent dans l’autisme adulte. Il apparaît que la maladie somatique peut échapper au discernement, en raison d’un envahissement trop important de la structure psychopathologique de l’autisme et d’une absence de connaissances des maladies somatiques. Parallèlement, la méconnaissance de la médecine somatique vers l’accompagnement soignant de la façon d’être autistique, montre une défaillance susceptible d’empêcher l’accès aux soins. Conformément au Plan autisme 2013, pour tenter de contrarier ces deux tendances, nous plaidons en faveur d’une formation pour les soignants intervenant en somatique et pour les soignants intervenant en psychiatrie, en rappelant que ce rapprochement, programmé dans le plan, noue les deux grandes peurs de nos sociétés modernes : la mort et la folie.
Incidence and Risk of Infection in Egyptian Patients with Systemic Lupus Erythematosus
Authors: Mohamed Dalia F. , Habeeb Reem A. , Hosny Sherin M. , Ebrahim Shafika E. 
Published: July 2014

Background Infection in systemic lupus erythematosus (SLE) is common and is one of the leading causes of morbidity and mortality. Objective To study the risk and occurrence of infection in Egyptian SLE patients and to determine its characteristics. Methods A total of 200 SLE patients were followed up for 1 year at monthly intervals, undergoing clinical and laboratory evaluation. Disease activity was assessed by SLE disease activity measurement (SLAM) score. Infections were diagnosed on basis of clinical findings, medical opinion, positive blood and urine cultures, Gram stain results, and specific serological assays as measurement of CMV and EBV antibodies. Results A total of 55% of patients developed infection, 45% had one infection, and the rest had multiple infection episodes. Total number of infections was 233 infections/year, 47.2% were major and 52.8% were minor infections. Urinary tract was the most commonly involved site with bacterial infection being the commonest isolated organism (46.4%), and E. coli the commonest isolated bacteria (14.2%). There were 51 episodes caused by systemic viral infection (CMV in 25, EBV in 22, HCV in 3, and 1 in HBV). Conclusion There is a high rate of infection among SLE patients. Disease activity, leukopenia, high CRP level, positive anti-dsDNA, consumed C3, and cyclophosphamide therapy are independent risk factors for infection in SLE.
Combined First-Trimester Screening in Northern Finland: Experiences of the First Ten Years
Authors: Anna Merilainen , Sini Peuhkurinen , Timppa Honkasalo , Paivi Laitinen , Hannaleena Kokkonen , Markku Ryynanen , Jaana Marttala 
Published: July 2014

Objective To evaluate the efficacy of first trimester combined screening for Down's syndrome in Northern Finland during the first 10 years of practice. Methods During 1 January 2002 to 31 December 2011, 47,896 women participated voluntarily in combined screening during first trimester. The risk cutoff was 1:250. The study period was divided into two time periods; 2002-2006 and 2007-2011. Results During the first half of the study period, the detection rate (DR) was 77.3% with a 4.9% false-positive rate (FPR). During the latter half, the DR was 77.1% with a 2.8% FPR. Conclusions An important issue is the number of invasive procedures needed to detect one case of Down's syndrome. The screening performance improved markedly in the latter five years period since the FPR lowered from 4.9% to 2.8% and the number of invasive procedures needed to detect one case of Down's syndrome lowered from 15 to 11.
Comprehensive electronic medical record implementation levels not associated with 30-day all-cause readmissions within Medicare beneficiaries with heart failure.
Authors: Marken P. , Zhong Y. , Simon S. D. , Ketcherside W. , Patterson M. E. 
Published: July 2014

SummaryBackground: Regulatory standards for 30-day readmissions incentivize hospitals to improve quality of care. Implementing comprehensive electronic health record systems potentially decreases readmission rates by improving medication reconciliation at discharge, demonstrating the additional benefits of inpatient EHRs beyond improved safety and decreased errors.Objective: To compare 30-day all-cause readmission incidence rates within Medicare fee-for-service with heart failure discharged from hospitals with full implementation levels of comprehensive EHR systems versus those without.Methods: This retrospective cohort study uses data from the American Hospital Association Health IT survey and Medicare Part A claims to measure associations between hospital EHR implementation levels and beneficiary readmissions. Multivariable Cox regressions estimate the hazard ratio of 30-day all-cause readmissions within beneficiaries discharged from hospitals implementing comprehensive EHRs versus those without, controlling for beneficiary health status and hospital organizational factors. Propensity scores are used to account for selection bias.Results: The proportion of heart failure patients with 30-day all-cause readmissions was 30%, 29%, and 32% for those discharged from hospitals with full, some, and no comprehensive EHR systems. Heart failure patients discharged from hospitals with fully implemented comprehensive EHRs compared to those with no comprehensive EHR systems had equivalent 30-day readmission incidence rates (HR = 0.97, 95% CI 0.73 – 1.3)Conclusions: Implementation of comprehensive electronic health record systems does not necessarily improve a hospital’s ability to decrease 30-day readmission rates. Improving the efficiency of post-acute care will require more coordination of information systems between inpatient and ambulatory providers.Citation: Patterson ME, Marken P, Zhong Y, Simon SD, Ketcherside W. Comprehensive electronic medical record implementation levels not associated with 30-day all-cause readmissions within Medicare beneficiaries with heart failure. Appl Clin Inf 2014; 5: 670–684http://dx.doi.org/10.4338/ACI-2014-01-RA-0008
Por uma Perspectiva Culturalista nos Estudos de Comunicação
Authors: SOUZA Humberto Da Cunha Alves de 
Published: July 2014

Bauman explora, na obra A cultura no mundo líquido moderno, como o conceito de cultura assumiu diferentes “missões” desde sua interpretação mais original a serviço das elites culturais, até estar a serviço da sedução na sociedade de consumo – período que o autor chama de modernidade líquida. É preciso lembrar que esse período é tratado por outros autores como pós-modernidade, modernidade tardia, hipermodernidade; metáforas que, como justificou o próprio Bauman, não é seu objetivo debater. O que chama atenção é a linguagem complexa do autor, característica que se identifica na leitura de outras obras. Exige-se, portanto, profunda atenção do leitor; bem como seu conhecimento prévio de que Bauman é um estudioso cuidadoso da “sociedade de consumo”, conceito muito presente em suas obras.
Clinical Consequences of Specimen Rejection: A College of American Pathologists Q-Probes Analysis of 78 Clinical Laboratories
Authors: Karcher Donald S. , Lehman Christopher M. 
Published: July 2014

Context.—Clinical laboratory specimens may be rejected as unsuitable for analysis for a variety of reasons and specimen rejection may have significant clinical consequences.Objective.—To quantify the clinical consequences of specimen rejection and determine the impact of laboratories' policies and practices on these consequences.Design.—Participants prospectively reviewed consecutive blood and urine specimens submitted to the chemistry and/or hematology laboratories to identify rejected specimens. For each rejected specimen, the patient's age, specimen type, testing priority, rejection reason, time from specimen receipt to receipt of recollected/relabeled specimen, recollection method, and test result time were recorded. Specimen/test abandonment was determined by failure to recollect or relabel a rejected specimen. Each laboratory's policy regarding relabeling of incorrectly labeled specimens was recorded, along with how many relabeled specimens were subsequently discovered to be mislabeled.Results.—Specimen rejection led to a (1) high rate of specimen recollection, (2) delay in result availability (median of 65 minutes), and (3) high rate of specimen/test abandonment. Longer test result delay was associated with higher hospital bed size; and higher test abandonment rate, with failure of the laboratory to request specimen recollection. Relabeling of incorrectly labeled specimens was found to be of little benefit and was associated with a substantial percentage of subsequently mislabeled specimens.Conclusion.—Specimen rejection has significant clinical consequences, including patient discomfort, significant delay in result availability, and high rate of specimen/test abandonment. Allowing routine relabeling of incorrectly labeled specimens is a dangerous practice, with little measureable benefit and with an increased risk to patient safety.
Histologic Grade Remains a Prognostic Factor for Breast Cancer Regardless of the Number of Positive Lymph Nodes and Tumor Size: A Study of 161 708 Cases of Breast Cancer From the SEER Program
Authors: Schwartz Arnold M. , Henson Donald Earl , Chen Dechang , Rajamarthandan Sivasankari 
Published: July 2014

Context.—The appropriate staging of breast cancers includes an evaluation of tumor size and nodal status. Histologic grade in breast cancer, though important and assessed for all tumors, is not integrated within tumor staging.
Objective.—To determine whether the histologic grade remains a prognostic factor for breast cancer regardless of tumor size and the number of involved axillary lymph nodes.
Design.—By using a new clustering algorithm, the 10-year survival for every combination of T, N, and the histologic grade was determined for cases of breast cancer obtained from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute. There were 36 combinations of TN, defined according to the American Joint Committee on Cancer, and grade.
Results.—For each combination of T and N, a categorical increase in the histologic grade was associated with a progressive decrease in 10-year survival regardless of the number of involved axillary lymph nodes or size of the primary tumor. Absolute survival differences between high and low grade persisted despite larger tumor sizes and greater nodal involvement, though trends were apparent with increasing breast cancer stage. Statistical significance depended on the number of cases for each combination.
Conclusions.—Histologic grade continues to be of prognostic importance for overall survival despite tumor size and nodal status. Furthermore, these results seem to indicate that the assignment of the histologic grade has been consistent among pathologists when evaluated in a large data set of patients with breast cancer. The incorporation of histologic grade in TNM staging for breast cancer provides important prognostic information.
Performance Evaluation of Samsung LABGEOHC10 Hematology Analyzer
Authors: Park Il Joong , Ahn Sunhyun , Kim Young In , Kang Seon Joo , Cho Sung Ran 
Published: July 2014

Context.—The Samsung LABGEOHC10 Hematology Analyzer (LABGEOHC10) is a recently developed automated hematology analyzer that uses impedance technologies. The analyzer provides 18 parameters including 3-part differential at a maximum rate of 80 samples per hour.
Objective.—To evaluate the performance of the LABGEOHC10.
Design.—We evaluated precision, linearity, carryover, and relationship for complete blood cell count parameters between the LABGEOHC10 and the LH780 (Beckman Coulter Inc) in a university hospital in Korea according to the Clinical and Laboratory Standards Institute guidelines. Sample stability and differences due to the anticoagulant used (K2EDTA versus K3EDTA) were also evaluated.
Results.—The LABGEOHC10 showed linearity over a wide range and minimal carryover (&lt;1%) for white blood cell, hemoglobin, red blood cell, and platelet parameters. Correlation between the LABGEOHC10 and the LH780 was good for all complete blood cell count parameters (R &gt; 0.92) except for mean corpuscular hemoglobin concentration. The bias estimated was acceptable for all parameters investigated except for monocyte count. Most parameters were stable until 24 hours both at room temperature and at 4°C. The difference by anticoagulant type was statistically insignificant for all parameters except for a few red cell parameters.
Conclusions.—The accurate results achievable and simplicity of operation make the unit recommendable for small to medium-sized laboratories.