bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasmacytoid dendritic cells in hypertrophic discoid lupus erythematosus: an objective evaluation of their diagnostic value
Authors: Walsh Noreen M. , Lai Jonathan , Hanly John G. , Green Peter J. , Bosisio Francesca , Garcias‐Ladaria Juan , Cerroni Lorenzo 
Published: November 2014

BackgroundHypertrophic discoid lupus erythematosus (HDLE), a rare variant of lupus skin disease, is difficult to distinguish from squamous neoplasms and certain dermatoses microscopically. Recently, recognition of the pathogenetic significance of plasmacytoid dendritic cells (PDCS) in cutaneous lupus erythematosus (LE) and of their patterns of distribution in different manifestations of the disease prompted us to study their diagnostic value in the context of HDLE.MethodsUsing immunohistochemistry (CD123) to label the cells, we examined their quantities and patterns of distribution in 27 tissue samples of HDLE from nine patients compared with 39 inflammatory and neoplastic control samples from 36 patients.ResultsUsing three parameters pertaining to PDCs: (i) their representation of 10% or more of the inflammatory infiltrate, (ii) their arrangement in clusters of 10 cells or more and (iii) their presence at the dermoepidermal junction, we found them to have significant diagnostic value, with accuracies of 77%, 74% and 71%, respectively.ConclusionsThis study supports the careful descriptive observations of previous authors in the field. It also lends validity to the diagnostic step of mapping, immunohistochemically, the density and distribution of PDCs in suspected cases of HDLE.
Evaluating protected area effectiveness using bird lists in the Australian Wet Tropics
Authors: Barnes Megan , Szabo Judit K. , Morris William K. , Possingham Hugh 
Published: November 2014

AbstractAimProtected areas underpin many global conservation efforts. However, it is often unclear whether they are effective in maintaining their biodiversity values, both absolutely, and also relative to other conservation actions or land uses. Longitudinal population data are critical for determining protected area performance robustly, but such data are rare. As such, there is often insufficient information with which to make adequate, informed decisions for policy and management. Conversely, informally collected data, such as species lists, are common, especially for birds, and they are often the only source of historical data. The aim of this study was to use list data to evaluate the contribution of protected areas to the conservation of endemic birds.LocationWet Tropics bioregion of Queensland, Australia.MethodsWe used a list‐length analysis (LLA), a recently developed approach. We estimate trends in species populations with a Bayesian logistic regression to infer bird presence from non‐standardized volunteer‐collected bird surveys from the New Atlas of Australian Birds that were conducted both inside and outside protected areas.ResultsOverall, the prevalence of the majority of wet tropics endemics (18 of 21) has been stable since 1998. Sixteen species were more likely to be found within protected areas, two were more likely to be recorded outside, and three showed little difference. However, there was no difference in trends in prevalence between protected and unprotected areas for all but one endemic species.Main conclusionsWhere formal data collection is too expensive or time consuming, it may still be possible to inform decision‐making when citizen‐collected species list data are available. In the Wet Tropics, our results suggest that for the majority of the species, protected areas may contain better habitat than unprotected areas, but that birds inside protected areas are not significantly better off through time than birds outside protected areas, as long as forest outside protected areas remains intact.
Ruptured Aneurysm of Anterior Mitral Leaflet in Aortic Valve Infective Endocarditis
Authors: Zegrí Isabel , Moñivas Vanessa , Mingo Susana , Garcia‐Montero Carlos , Cavero Miguel A. 
Published: November 2014

Mini‐AbstractWe report the case of a 71‐year‐old man admitted with acute heart failure and suspicion of infective endocarditis (IE). Three‐dimensional transesophageal echocardiography (3DTEE) showed ruptured aneurysm of anterior mitral leaflet (AAML) in scallop A2 with severe mitral regurgitation and perforation of right and noncoronary aortic cusps with severe aortic regurgitation. TEE is more sensitive than transthoracic echocardiography for the diagnosis of AAML and 3DTEE provides further morphological information as well about the relationship with adjacent structures. This information has important implications for medical and surgical purposes.
More than seizures: improving the lives of people with refractory epilepsy
Authors: Mula M. , Cock H. R. 
Published: November 2014

As captured by the proposed new definition, epilepsy is increasingly recognized as a disorder characterized not only by an enduring predisposition to recurrent seizures but explicitly also by the neurobiological, cognitive, psychological and social consequences of this condition. Further, both in the estimated 15 million people worldwide who have ongoing seizures despite optimal management and in a substantial proportion of those in remission, the consequences and comorbidities of epilepsy are the major determinants of quality of life. These include mood disorders such as anxiety and depression, dose related and longer term effects of antiepileptic drugs, including on prenatal development and bone health, and neurobehavioural effects. Whilst separating those that are part of an underlying condition or have unrelated contributors from those that are potentially remediable can be difficult, given the range of tools now available to assist with screening and management there is no excuse for not at least trying as part of standard care for people with epilepsy. Managing epilepsy well is about much more than controlling seizures and this needs to be recognized in planning and delivering services, as well as in prioritizing research.
Identification of two p23 co‐chaperone isoforms in Leishmania braziliensis exhibiting similar structures and Hsp90 interaction properties despite divergent stabilities
Authors: Batista Fernanda A.H. , Almeida Glessler S. , Seraphim Thiago V. , Silva Kelly P. , Murta Silvane M.F. , Barbosa Leandro R.S. , Borges Júlio C. 
Published: November 2014

The small acidic protein called p23 acts as a co‐chaperone for heat‐shock protein of 90 kDa (Hsp90) during its ATPase cycle. p23 proteins inhibit Hsp90 ATPase activity and show intrinsic chaperone activity. A search for p23 in protozoa, especially trypanosomatids, led us to identify two putative proteins in the Leishmania braziliensis genome that share approximately 30% identity with each other and with the human p23. To understand the presence of two p23 isoforms in trypanosomatids, we obtained the recombinant p23 proteins of L. braziliensis (named Lbp23A and Lbp23B) and performed structural and functional studies. The recombinant proteins share similar solution structures; however, temperature‐ and chemical‐induced unfolding experiments showed that Lbp23A is more stable than Lbp23B, suggesting that they may have different functions. Lbp23B prevented the temperature‐induced aggregation of malic dehydrogenase more efficiently than did Lbp23A, whereas the two proteins had equivalent efficiencies with respect to preventing the temperature‐induced aggregation of luciferase. Both proteins interacted with L. braziliensis Hsp90 (LbHsp90) and inhibited its ATPase activity, although their efficiencies differed. In vivo identification studies suggested that both proteins are present in L. braziliensis cells grown under different conditions, although Lbp23B may undergo post‐translation modifications. Interaction studies indicated that both Lbp23 proteins interact with LbHsp90. Taken together, our data suggest that the two protozoa p23 isoforms act similarly when regulating Hsp90 function. However, they also have some differences, indicating that the L. braziliensis Hsp90 machine has features providing an opportunity for novel forms of selective inhibition of protozoan Hsp90.
Regenerative endodontic treatment of an immature tooth with a necrotic pulp and apical periodontitis using platelet‐rich plasma (PRP) and mineral trioxide aggregate (MTA): a case report
Authors: Sachdeva G. S. , Sachdeva L. T. , Goel M. , Bala S. 
Published: November 2014

AbstractAimTo report the successful clinical and radiographic outcome of a regenerative endodontic treatment.SummaryA 16‐year‐old male patient presented with a discoloured, maxillary left lateral incisor with a necrotic pulp. Radiographic examination revealed an incompletely developed root with an open apex. Under local anaesthesia and rubber dam isolation, an access cavity was prepared and the necrotic pulpal remnants were removed. The canal was disinfected without mechanical instrumentation with 5.25% NaOCl solution and dried with sterile paper points. A triple antibiotic (metronidazole, ciprofloxacin and minocycline) mixed with distilled water was packed in the canal and left for 28 days. Ten millimetres of whole blood was drawn by venipuncture from the patients antecubital vein for preparation of platelet‐rich plasma (PRP). After removal of the antibiotic mixture, the PRP was injected into the canal space up to the cementoenamel junction level. Three millimetres of white MTA was placed directly over the PRP clot. Two days later, the tooth was restored with permanent filling materials. The patient was recalled for 3, 6, 12, 24 and 36 months clinical/radiographic follow‐up. A 3‐year follow‐up radiograph revealed resolution of the periapical lesion, increased thickening of the root walls, further root development and continued apical closure of the root apex. The tooth was not responsive to cold tests; however, sensitivity tests with an electric pulp tester (EPT) elicited a delayed positive response.Key learning points

Regeneration is a viable treatment modality that allows continued root development of immature teeth with open apices and necrotic pulps.

Platelet‐rich plasma appears to be a suitable scaffold for regeneration of vital tissues in teeth with a necrotic pulps and an associated periapical lesion.

Regenerative endodontic procedures may offer an effective treatment option to save teeth with compromised structural integrity.
TIA Triage in Emergency Department Using Acute MRI (TIA-TEAM): A Feasibility and Safety Study
Authors: Vora Nirali , Tung Christie E. , Mlynash Michael , Garcia Madelleine , Kemp Stephanie , Kleinman Jonathan , Zaharchuk Greg , Albers Gregory , Olivot Jean-Marc 
Published: November 2014

Background Positive diffusion weighted imaging (DWI) on MRI is associated with increased recurrent stroke risk in TIA patients. Acute MRI aids in TIA risk stratification and diagnosis. Aim To evaluate the feasibility and safety of TIA triage directly from the emergency department (ED) with acute MRI and neurological consultation. Methods Consecutive ED TIA patients assessed by a neurologist underwent acute MRI/MRA of head/neck per protocol and were hospitalized if positive DWI, symptomatic vessel stenosis, or per clinical judgment. Stroke neurologist adjudicated the final TIA diagnosis as definite, possible, or not a cerebrovascular event. Stroke recurrence rates were calculated at 7, 90, 365 days and compared with predicted stroke rates derived from historical DWI and ABCD2 score data. Results One hundred twenty-nine enrolled patients had a mean age of 69 years (±17) and median ABCD2 score of 3 (interquartile range [IQR] 3–4). During triage, 112 (87%) patients underwent acute MRI after a median of 16 h (IQR 10–23) from symptom onset. No patients experienced a recurrent event before imaging. Twenty-four (21%) had positive DWI and 8 (7%) had symptomatic vessel stenosis. Of the total cohort, 83 (64%) were discharged and 46 (36%) were hospitalized. By one-year follow-up, one patient in each group had experienced a stroke. Of 92 patients with MRI and index cerebrovascular event, recurrent stroke rates were 1·1% at 7 and 90 days. These were similar to predicted recurrence rates. Conclusion TIA triage in the ED using a protocol with neurological consultation and acute MRI is feasible and safe. The majority of patients were discharged without hospitalization and rates of recurrent stroke were not higher than predicted.
Why closing the Aboriginal health gap is so elusive
Authors: Gracey M. 
Published: November 2014

AbstractA wide gap persists between the health of Aboriginal and non‐Aboriginal Australians despite a recent Federal government commitment to close the gap by 2030. The complex underlying factors include socioeconomic and environmental disadvantage, inadequate education, underemployment, racial prejudice, high‐risk health‐related behaviours and limited access to clinical services and health promotion programmes. Over recent decades some aspects of Aboriginal health have deteriorated badly, largely from a surge in chronic ‘lifestyle’ diseases like diabetes, cardiovascular and kidney disorders plus the effects of tobacco smoking, alcohol and drug abuse and high rates of violence and trauma. To correct these inequities will require improving many social and environmental factors. These include education, living conditions, vocational training, employment, closer cooperation between government and non‐government agencies, access to affordable and nutritious fresh food, with better access to high‐quality medical treatment, health promotion and disease prevention programmes. Indigenous people must be encouraged to become more involved in activities to improve their health and have more responsibility for the decision‐making processes this will entail. Governments must support these changes to help close the Aboriginal health gap.
Evangelism and Popular Culture
Authors: Währisch‐Oblau Claudia 
Published: November 2014

AbstractThis article reports on the work and the deliberations of the United Evangelical Mission's Working Group on Evangelism and Popular Culture. Working with rough heuristic categories, the group identifies Protestantism's discomfort with popular cultural expressions and finds it rooted in Protestant history and modernist cultural theory. Using a postmodernist approach that looks at ways of meaning making in popular culture, the group calls for theological discernment and the identification of the work of the Holy Spirit within popular cultural expressions. Following J. K. A. Smith, liturgies are identified as shaping human identities. Secular, thick liturgies are often far more influential than Christian thin practices. Popular culture is a mirror of groundbreaking social change, but classical Protestant churches still follow the organizational principles of the 19th century. The group argues that to evangelize within popular culture, these churches will have to change their shape and structures, becoming missional but not consumer‐driven.
The Apostolic Exhortation Evangelii Gaudium on the Proclamation of the Gospel in Today's World
Authors: Bevans Stephen 
Published: November 2014

AbstractPope Francis's Apostolic Exhortation Evangelii Gaudium has much to teach both Catholics and other Christians about the way the gospel needs to be proclaimed in today's world. This article first outlines five implications of the document for gospel preaching: the embodiment of the gospel in the church, a message of joy, a message of mercy and tenderness, a contextualized message, and a message in solidarity with the poor. It then sketches four prospects of these implications in terms of the church. The message calls for a church of “missionary disciples,” a church that is “poor and for the poor,” a de‐clericalized church, and a church of dialogue.
Expressions of Evangelism in Latin America
Authors: Alfaro Rubén (Tito) Paredes 
Published: November 2014

AbstractThe purpose of this article is to explore the expressions of evangelism that are emerging in Latin America within the Evangelical‐Pentecostal context of the continent. We will do this by approaching our subject from the perspective of change, religious mutation and transformational change: we will first refer to the shift in evangelism and mission perspective in Latin America. We will explore the shift in numerical growth, then will deal with the shift in the concept and praxis of evangelism. This will be followed by a discussion on the shift from Western forms in church liturgy, music and hymnology to more contextual and indigenous expressions. Finally, I will refer to the shift toward holistic practices in times of turmoil and violence.
Species richness and areas of endemism of oryzomyine rodents (Cricetidae, Sigmodontinae) in South America: an ndm/vndm approach
Authors: do Prado Joyce R. , Brennand Pamella G. G. , Godoy Leandro P. , Libardi Gustavo S. , de Abreu‐Júnior Edson F. , Roth Paulo R. O. , Chiquito Elisandra A. , Percequillo Alexandre R. 
Published: November 2014

AbstractAimTo infer areas of endemism for the tribe Oryzomyini in South America by employing a database of species richness and geographical distribution, and to compare these results with areas of endemism and species richness proposed in the literature for other taxa.LocationWe analysed specimens of the tribe Oryzomyini distributed throughout South and Central America, which are housed in European, North and South American museums and collections.MethodsWe analysed 2768 occurrence records for 102 species of the tribe Oryzomyini using the ndm/vndm algorithm and three different grid sizes to assess the possible effects of grid cell area on the results.ResultsUsing the overlap of consensus areas in South America, we identified three generalized areas of endemism for the Oryzomyini: north‐western South America (NWSA), eastern South American (ESA), and northern South America (NSA); we also identified the Galápagos archipelago (GA) as an area of endemism.Main conclusionsAreas of endemism detected in the continental portion of South America include its three main mountain chains: the Andes Cordillera, the Guyanan Shields, and an area east of the Brazilian Shield named Serra do Mar. Each of these regions encompasses many different types of vegetation, and the species richness and composition of the areas of endemism of the tribe are directly related to this environmental diversity. Different grid sizes affected the distributional heterogeneity of the consensus areas. The smallest grid cell size identified mainly Andean areas, which contain a higher number of more exclusive species in a small area along a steep elevational gradient. In contrast, the largest grid size identified areas of endemism along an environmental gradient that co‐varied with latitude and longitude. The identified areas of endemism are corroborated by previous studies on other taxa.
Feasibility and Efficacy of Percutaneously Delivered Leadless Cardiac Pacing in an In Vivo Ovine Model
Authors: KORUTH JACOB S. , RIPPY MARIAN K. , KHAIRKHAHAN ALEXANDER , LIGON DAVID A. , HUBBARD CHRISTOPHER A. , GOAR FREDERICK ST. , LEE RANDALL , RIBEIRO LEONARDO , MILLER MARC , DUKKIPATI SRINIVAS , NEUZIL PETR , REDDY VIVEK Y. 
Published: November 2014

Preclinical Feasibility of a Leadless PacemakerIntroductionIn this in vivo ovine study, we describe the course of pacing and sensing parameters during follow‐up as well as the gross and histopathological features at the implant site of the recently described leadless cardiac pacemaker (LCP).Methods and ResultsAll sheep underwent LCP implantation in the right ventricular (RV) apex. Serial pacing/sensing thresholds were assessed. In the first cohort, 11 animals were followed up for a period of 3 months, followed by necropsy. In the second cohort, 7 additional sheep were followed for a period of up to 18 months. Mean pacing and sensing thresholds in the 3‐month cohort were 1.0 ± 0.5 V and 9.0 ± 3.7 mV at implant, and 0.7 ± 0.2 V and 8.1 ± 3.9 mV at 90 days, respectively. At necropsy at 3 months, all devices were securely implanted at the RV apex without extrusion of helix beyond the RV wall. Besides endocardial reactive changes in the RV apex surrounding the distal portion of the LCP, there were no other grossly visible abnormalities. In the second cohort (7 sheep), mean pacing and sensing thresholds were 1.0 ± 0.5 V and 9.9 ± 3.8 mV at implant, and 0.86 ± 0.4 V and 4.25 ± 1 mV, respectively, at 18 months of follow‐up.ConclusionWe demonstrate that after implantation of the LCP, pacing/sensing parameters remain adequate up to 18 months in follow‐up. In addition, pathological changes at the implant site and within the RV are limited in severity at 90 days, supporting the efficacy and safety of this novel approach to pacing.
Restructuring Care for Older Adults Undergoing Surgery: Preliminary Data from the Co‐Management of Older Operative Patients En Route Across Treatment Environments (CO‐OPERATE) Model of Care
Authors: Walke Lisa M. , Rosenthal Ronnie A. , Trentalange Mark , Perkal Melissa F. , Maiaroto Maria , Jeffery Sean M. , Marottoli Richard A. 
Published: November 2014

Surgery is common in older adults, so geriatric and surgical providers need to develop expertise in the care of older adults undergoing surgery. The Co‐management of Older Operative Patients En Route Across Treatment Environments (CO‐OPERATE) program is a clinical and educational collaboration between geriatrics and several surgical specialties at Veterans Affairs Health Care Connecticut. Individuals in CO‐OPERATE are co‐managed during the pre‐, peri‐, and postoperative periods. General surgery, urology, vascular surgery, orthopedics, cardiothoracic surgery and neurosurgery all participate in the program, with geriatrics expertise provided by a geriatrician, geriatric nurse practitioner and a geriatric clinical pharmacist. In the initial 3 years, there were 211 CO‐OPERATE participants; 31% were evaluated preoperatively, and 62% of the individuals seen preoperatively were seen in clinic. There was a median of three recommendations per consultation. At discharge, 56% returned to the community. Individuals seen preoperatively were more likely to return to the community (63%) than those seen after surgery (50%, P = .10). Geriatrics co‐management with a variety of surgical specialties is feasible and may be associated with higher rates of discharge back to the community.