bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuities and discontinuities in pharmaceutical treatment and medication use among older chronically ill patients of Turkish descent in Germany: a qualitative structuring content analysis
Authors: Tezcan-Güntekin Hürrem , Bird Rona , Aslan Sema , Kul Yagmur , Azman Özge , Aykaç Volkan , Klammt Beate , Aslan Meryem , Özer-Erdoğdu Ilknur 
Published: August 2024

BackgroundPolypharmacy occurs frequently among older adults and is associated with an increased risk of falls and medication-related adverse events. In particular, people with a history of migration may receive inappropriate medication due to language barriers or discrimination in healthcare. This study aims to assess the continuities, discontinuities and barriers to drug therapy in older migrants of Turkish descent in Berlin, Germany.MethodsEleven problem-centered qualitative interviews with chronically ill older persons of Turkish descent and family caregivers were conducted and analyzed qualitatively by means of structuring content analysis.ResultsThe chronically ill participants of Turkish descent predominantly take more than 5 types of medication per day and aim to take them regularly. Discontinuities emerge when medication is forgotten or intentionally omitted due to side effects. Frequent changes in medication and physicians' lack of time are relevant barriers to drug treatment plans. To avoid language barriers and disinterest on the part of professionals, respondents prefer Turkish-speaking physicians.
Relevant factors affecting nurse staffing: a qualitative study from the perspective of nursing managers
Authors: Li Gege , Wang Waner , Pu Jiangfeng , Xie Zhanghao , Xu Yixuan , Shen Tiemei , Huang Huigen 
Published: August 2024

ObjectiveTo understand the current situation of nursing manpower allocation, explore the factors affecting nurse staffing, improve nurse staffing level, and provide reference for better formulation of nursing human resources staffing standards.MethodsA descriptive research method was used to conduct semi-structured interviews with 14 nursing managers. The data were analyzed and refined by content analysis. The sample size was subject to content saturation.ResultsNine themes and twenty sub-themes of influencing factors for nursing staffing were identified across four levels: hospital level, department level, patient level, and nurse level.ConclusionHospital and department managers need to comprehensively consider the factors of affecting nurse staffing. Adopting multidimensional optimization measures, improving relevant systems, optimizing nurse structure, and establishing flexible and mobile nurse database to cope with public emergencies, so as to effectively improve nurse staffing and nursing service quality.
Effectiveness of Enriched Milk with Ashwagandha Extract and Tryptophan for Improving Subjective Sleep Quality in Adults with Sleep Problems: A Randomized Double-Blind Controlled Trial
Authors: Pérez-Piñero Silvia , Muñoz-Carrillo Juan Carlos , Echepare-Taberna Jon , Muñoz-Cámara Macarena , Herrera-Fernández Cristina , Ávila-Gandía Vicente , Heres Fernández Ladreda María , Menéndez Martínez Javier , López-Román Francisco Javier 
Published: August 2024

A randomized, double-blind and controlled study was conducted to assess the effectiveness of the intake of 250 mL of lactose-free skimmed milk enriched with ashwagandha (Withania somnifera) alone or combined with tryptophan vs. non-enriched milk (control) on the subjective quality of sleep in healthy adults with sleep problems. The duration of supplementation was 90 days. Fifty-two eligible subjects were assigned to the study arms of ashwagandha 250 mg, ashwagandha 250 mg plus tryptophan 175 mg, ashwagandha 600 mg, and control with 13 subjects in each group. It was hypothesized that ashwagandha plus tryptophan could be superior to ashwagandha alone for improving sleep-related variables. Changes in the visual analogue scale (VAS) for sleep quality were significantly higher in the three experimental groups as compared with controls (p = 0.014). Improvements in the subscales of the Pittsburg Sleep Quality Index (PSQI) were found in all groups, but between-group differences were not significant. In the index of insomnia severity, decreases were higher in the three experimental groups as compared with controls especially in the group of ashwagandha 600 mg. Daytime somnolence was also reduced in the three experimental groups. Changes in anxiety levels and Morningness–Eveningness Questionnaire were not observed. The study products did not elicit changes in body composition and were well tolerated and safe. The data did not support the hypothesis, as the combination of ashwagandha and tryptophan did not show greater benefits in improving sleep quality than ashwagandha alone. However, the results from the three experimental groups containing ashwagandha were more favorable compared to the placebo group.
Genome-Wide Characterization and Haplotypic Variation Analysis of the IDD Gene Family in Foxtail Millet (Setaria italica)
Authors: Wu Hongpo , Zhang Renliang , Diao Xianmin 
Published: August 2024

The indeterminate domain proteins (IDD proteins) play essential roles in the growth and development of various plant tissues and organs across different developmental stages, but members of this gene family have not yet been characterized in foxtail millet (Setaria italica). To have a comprehensive understanding of the IDD gene family in foxtail millet, we performed a genome-wide characterization and haplotypic variation analysis of the IDD gene family in foxtail millet. In this study, sixteen IDD genes were identified across the reference genome of Yugu1, a foxtail millet cultivar. Phylogenetic analysis revealed that the Setaria italica IDD (SiIDD) proteins were clustered into four groups together with IDD proteins from Arabidopsis thaliana (dicot) and Oryza sativa (monocot). Conserved protein motif and gene structure analyses revealed that the closely clustered SiIDD genes were highly conserved within each subgroup. Furthermore, chromosomal location analysis showed that the SiIDD genes were unevenly distributed on nine chromosomes of foxtail millet and shared collinear relationships with IDD genes of other grass species. Transcriptional analysis revealed that the SiIDD genes differed greatly in their expression patterns, and paralogous genes shared similar expression patterns. In addition, superior haplotypes for two SiIDD genes (SiIDD8 and SiIDD14) were identified to correlate with traits of early heading date, and high thousand seed weight and molecular markers were designed for SiIDD8 and SiIDD14 to distinguish different haplotypes for breeding. Taken together, the results of this study provide useful information for further functional investigation of SiIDD genes, and the superior haplotypes of SiIDD8 and SiIDD14 will be particularly beneficial for improving heading date and yield of foxtail millet in breeding programs.
Salmonirosea aquatica gen. nov., sp. nov., a Novel Genus within the Family Spirosomaceae, Was Isolated from Brackish Water in the Republic of Korea
Authors: Baek Kiwoon , Jang Sumin , Goh Jaeduk , Choi Ahyoung 
Published: August 2024

A Gram-stain-negative, obligately aerobic, non-motile, rod-shaped bacterial strain designated SJW1-29T was isolated from brackish water samples collected from the Seomjin River, Republic of Korea. The purpose of this study was to characterize strain SJW1-29T and determine its taxonomic position as a potential new genus within the family Spirosomaceae. The strain grew within the range of 10–30 °C (optimum, 25 °C), pH 5.0–10.0 (optimum, 7.0), and 1–4% NaCl (optimum, 3%). Phylogenetic analysis based on the 16S rRNA gene revealed that strain SJW1-29T belongs to the family Spirosomaceae and is closely related to Persicitalea jodogahamensis Shu-9-SY12-35CT (91.3% similarity), Rhabdobacter roseus R491T (90.6%), and Arundinibacter roseus DMA-K-7aT (90.0%), while the similarities to strains within the order Cytophagales were lower than 90.0%. The genome is 7.1 Mbp with a G+C content of 50.7 mol%. The use of genome-relatedness indices confirmed that this strain belongs to a new genus. The major polar lipid profile consisted of phosphatidylethanolamine, and MK-7 was the predominant menaquinone. The predominant fatty acids were summed feature 3 (C16:1 ω7c and/or C16:1 ω6c), iso-C15:0, iso-C17:0 3-OH, and C16:0, representing more than 80% of the total fatty acids. The phenotypic, chemotaxonomic, genetic, and phylogenetic properties suggest that strain SJW1-29T represents a novel species within a new genus in the family Spirosomaceae, for which the name Salmonirosea aquatica gen. nov., sp. nov., is proposed. The type strain of Salmonirosea aquatica is SJW1-29T (=KCTC 72493T = NBRC 114061T = FBCC-B16924T).
Hyaluronic Acid-Based Microparticles with Lubrication and Anti-Inflammation for Alleviating Temporomandibular Joint Osteoarthritis
Authors: Liu Lei , He Gang , Li Yixi , Xian Yiwen , He Guixian , Hong Yonglong , Zhang Chong , Wu Decheng 
Published: August 2024

The pathogenesis of temporomandibular joint osteoarthritis (TMJOA) is closely associated with mechanical friction, which leads to the up-regulation of inflammatory mediators and the degradation of articular cartilage. Injectable drug-loaded microparticles have attracted widespread interest in intra-articular treatment of TMJOA by providing lubrication and facilitating localized drug delivery. Herein, a hyaluronic acid-based microparticle is developed with excellent lubrication properties, drug loading capacity, antioxidant activity, and anti-inflammatory effect for the treatment of TMJOA. The microparticles are facilely prepared by the self-assembly of 3-aminophenylboronic acid-modified hyaluronic acid (HP) through hydrophobic interaction in an aqueous solution, which can further encapsulate diol-containing drugs through dynamic boronate ester bonds. The resulting microparticles demonstrate excellent injectability, lubrication properties, radical scavenging efficiency, and antibacterial activity. Additionally, the drug-loaded microparticles exhibit a favorable cytoprotective effect on chondrocyte cells in vitro under an oxidative stress microenvironment. In vivo experiments validate that intra-articular injection of drug-loaded microparticles effectively alleviates osteoporosis-like damage, suppresses inflammatory response, and facilitates matrix regeneration in the treatment of TMJOA. The HP microparticles demonstrate excellent injectability and encapsulation capacity for diol-containing drugs, highlighting its potential as a versatile drug delivery vehicle in the intra-articular treatment of TMJOA.
Efektivitas Penggunaan Media Kartu Huruf Terhadap Keterampilan Membaca Dan Menulis Kelas 1 Di SD Inpres Maccini Sombala 1 Kota Makassar
Authors: Nurdiana Andi , Hamsiah Andi , Burhan Burhan 
Published: August 2024

Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan media kartu huruf pada pembelajaran bahasa indonesia siswa SD Kecamatan Tamalate Kota Makassar. Jenis penelitian yang digunakan dalam penelitian ini adalah kuantitatif Hasil penelitian menunjukkan bahwa penggunaan media kartu huruf berpengaruh terhadap permulaan keterampilan membaca dan menulis murid kelas I sebelum digunakan media kartu huruf adalah 52,9 dan hasil belajar setelah digunakan media kartu huruf adalah 80,4. Angka tersebut menunjukkan bahwa ada penggunaan media kartu huruf terhadap keterampilan permulaan membaca dan menulis murid kelas I SD Inpres Maccini Sombala 1 dan hasil uji hipotesis (t-tes) menunjukkan angka signifikansi 0,000 dengan demikian hipotesis h1 dalam penelitian ini diterima. Nilai t-hitung = -12,120 berarti uji pihak kiri, sehingga t- hitung = -12,120 < - t- tabel = -2,086. “Dari nilai t-hitung yang negatif mengindikasikan bahwa nilai sebelum perlakuan lebih rendah dibanding setelah perlakuan”. Kesimpulannya adalah t-hitung > t-tabel yakni H0 ditolak dan H1 diterima “Efektifitas Penggunaan Media Kartu Huruf terhadap Keterampilan Permulaan Membaca dan Menulis Murid Kelas I SD Inpres Maccini Sombala 1”.
This research aims to determine the effectiveness of using letter card media in Indonesian language learning for elementary school students in Tamalate District, Makassar City. The type of research used in this research is quantitative. The results of the research show that the use of card media has an influence on the initial reading and writing skills of class I students before using card media is 52.9 and learning outcomes after using card media is 80.4. This figure shows that there is use of card media on the initial reading and writing skills of class I students at SD Inpres Maccini Sombala 1 and the results of the hypothesis test (t-test) show a significance figure of 0.000, thus hypothesis h1 in this study is accepted. The t-count value = -12.120 means the left-hand test, so the t-count = -12.120 < - t-table = -2.086. "The negative t-value indicates that the value before treatment is lower than after treatment." And the conclusion is t-count > t-table, namely H0 is rejected and H1 is accepted, meaning that the use of Letter Card Media is effective on the initial reading and writing skills of 1 st Class Students at SD Inpres Maccini Sombala 1".
MANEJO CIRÚRGICO DE INSUFICIÊNCIA CARDÍACA AGUDA EM PACIENTES PEDIÁTRICOS EM SERVIÇOS DE EMERGÊNCIA. REVISÃO DE LITERATURA
Authors: Lopes Felipe Eduardo Fagundes , Salgado Bruna Aparecida Pires , Ramos Lucas Seta , Silva Bruna Rosa , Esteves Marcelo Oliveira , Andrade Icaro Rodrigues , Peres Gabriel Francisco Ferrari , Azevedo Analina de Freitas , Henn Cássio Frederico Andrade , Vinhal Wanessa Campos , Júnior Carlos de oliveira farias , Dantas Valentina Arantes , Santos Joao Pedro Belchior , Aragão Ana Paula de , Domingues Elizete de Fátima 
Published: August 2024

Objetivo: Identificação e descrição das principais complicações do suporte circulatório utilizando a Oxigenação por Membrana Extracorpórea venoarterial dentro da pediatria (ECMO-VA) no tratamento avançado da Insuficiência Cardíaca (IC). Revisão da literatura: A IC é uma condição clínica caracterizada por uma deficiência estrutural ou funcional que afeta a função dos ventrículos, levando a uma inadequação no suprimento das necessidades metabólicas dos tecidos. Nesse sentido, a utilização do suporte de Oxigenação por Membrana Extracorpórea (ECMO) é recomendada em cinco cenários: como ponte para recuperação, ponte para decisão, ponte para implante de dispositivos de longa duração, ponte para transplante e tratamento de destino. Dessa forma, o suporte ECMO-VA é prescrito para fornecer suporte cardíaco em pacientes com ou sem função pulmonar preservada. Além disso, durante o uso do ECMO, surgem complicações associadas ao tratamento, que podem ser decorrentes do estado clínico do paciente ou do próprio dispositivo. Considerações finais: É evidente que esse procedimento invasivo representa uma das opções mais eficazes devido aos seus benefícios finais e aos resultados favoráveis na melhora dos pacientes.
GESTÃO DE SEPSE E INFECÇÕES AGUDAS: ABORDAGEM EM PACIENTES CIRÚRGICOS
Authors: Santos Priscylla Lucena , Oliveira Marcellus de Lucena , Aquilino Raphael Navarro , Santos Matheus Lucena , Irrazabal Leandro Aparecido , Costa Marcus Vinícius Cordeiro , Schiphorst Luana Vasconcellos Mendonça , Parreira Anelise Molinari , Melo Kadyja Ferraz de , Castiel Daniel Felipe Nobre , Aguiar Pedro Henrique Barroso , Oliveira Taina Santos , Durães Danielli Xavier Tamietti 
Published: August 2024

Introdução: A gestão de sepse e infecções agudas em pacientes cirúrgicos é essencial para prevenir complicações graves. A sepse, uma resposta inflamatória sistêmica a uma infecção, requer detecção precoce e tratamento rápido para evitar a progressão para choque séptico. Dessa forma, medidas como o uso de protocolos de monitoramento, administração imediata de antibióticos e higiene rigorosa das feridas são cruciais. Objetivo: Fornecer uma compreensão abrangente e prática sobre como identificar, tratar e prevenir a sepse e outras infecções agudas em pacientes que passaram por procedimentos cirúrgicos. Metodologia: Foram utilizadas as bases de dados Cochrane, Scielo e Medline, buscando artigos publicados entre os anos de 2022 e 2024, nos idiomas Português ou Inglês. Considerações Finais: A gestão de sepse e infecções agudas em pacientes cirúrgicos requer uma abordagem multidisciplinar e imediata, pois o reconhecimento precoce e o uso rápido de terapias antimicrobianas, junto com o controle da fonte de infecção, são cruciais. Além disso, o manejo hemodinâmico deve ser personalizado, e a prevenção por meio de protocolos de profilaxia e controle rigoroso de infecções é essencial.
TRATAMENTO DOS PACIENTES COM INSUFICIÊNCIA CARDÍACA NA UNIDADE DE TERAPIA INTENSIVA
Authors: Reis Viana Naiara Pereira dos , Silva Gemerson Clemenson da , Pinto Enzo Grobério , Morais Matheus Torquato , Lopes de Alencar Hugo Peixoto , Ferreira Thiago Araujo , Rodrigues Júlia Assis , Romiti Luísa Ribeiro , Daenecke Ferreira Maria Eduarda , Muzzy Leonardo Alves 
Published: August 2024

A Insuficiência Cardíaca (IC) pode ser definida como uma disfunção cardíaca onde o coração não é capaz de gerar um volume sistólico adequado para as demandas do organismo ou tem a capacidade de realização, porém com pressões de enchimento mais altas. A descompensação está relacionada ao início ou piora das manifestações clínicas das doenças que podem incluir dispneia e cansaço a realização de esforços físicos. A mortalidade dessa condição nos ambientes hospitalares pode ir de 20 a 60% dos casos, principalmente, em pacientes com outras comorbidades associadas. O objetivo do trabalho é analisar a importância do tratamento precoce nos pacientes com insuficiência cardíaca na unidade de terapia intensiva. Trata-se de uma revisão narrativa dos últimos 2 anos, do periodo de 2022 a 2024, utilizando a base de dados da MEDLINE com os descritores: "insuficiencia" "cardiaca" "manejo" "tratamento" "UTI". Evidencia-se a importância do diagnóstico e tratamento precoce da doença, uma vez que a postergação do tratamento está relacionada a um aumento da morbimortalidade. A cada 6 horas de postergação do tratamento, há um aumento de 6,8% da mortalidade. O tratamento deve ser individualizado a depender das condições clínicas dos pacientes. O tratamento pode ser com uso de diuréticos, vasodilatadores e oxigenoterapia (pacientes com hipoxemia). Nessa perspectiva, o tratamento é importante para melhorar o prognóstico do paciente e diminuir o tempo de internação hospitalar.
HARMONIZAÇÃO DO SORRISO GENGIVAL ATRAVÉS DE AUMENTO DE COROA CLÍNICA: RELATO DE CASO
Authors: Ludimila Sofia Machado Alves Teixeira  , Mateus Henrique Hermes da Silva  , Gabriella Rennisy de Sousa Silva  , Millena Mirella Silva de Araújo  , Ariela Vilela Rizuto  
Published: August 2024

Introdução: A busca por um sorriso mais estético e natural tem sido cada vez mais vislumbrada, para isto, é levado em consideração a posição, cor e formato dos dentes e o contorno gengival. Sendo assim, as cirurgias plásticas periodontais possuem um papel fundamental para construção de um sorriso mais harmônico e desejável. Para isto, é necessário um diagnóstico preciso e planejamento adequado do caso, com escolha da técnica cirúrgica mais indicada. Objetivo: O objetivo deste trabalho foi relatar um caso clínico de correção de sorriso gengival por meio da gengivoplastia. Relato de

Caso: Paciente do sexo feminino, 23 anos, apresentou como queixa principal insatisfação estética, com coroas clínicas dos dentes superiores curtas e excesso de exposição gengival ao sorrir. Após a avaliação clínica e periodontal, foi observado saúde periodontal, biótipo gengival espesso, erupção passiva alterada e sorriso gengival na região anterior superior. Após a solicitação e avaliação de exames complementares, foi realizado planejamento e execução de plastia periodontal com aumento de coroa clínica dos dentes 15 ao 25, através da técnica flapless. Conclusão: O diagnóstico e planejamento são essenciais na cirurgia plástica gengival, que quando bem executada, traz ao paciente resultados estéticos satisfatórios.
Karakter Agronomi Tanaman Bawang Merah (Allium ascalonicum L.) yang Diberi Perlakuan Pupuk Kasgot dan Zeolit di Tanah Inceptisol
Authors: Kharisun Kharisun , Pramesti Varadita Anggraeni , Hidayah Ratri Noor , Kurniawan Ruly Eko K. , Purwanto Purwanto 
Published: August 2024

Penelitian ini bertujuan untuk mengetahui pengaruh pemupukan kasgot dan zeolit terhadap karakter agronomi tanaman bawang merah di Inceptisol. Penelitian dilaksanakan di Screen House, Laboratorium Ilmu Tanah, dan Laboratorium Agronomi dan Hortikultura Fakultas Pertanian, Universitas Jenderal Soedirman, Purwokerto. Penelitian ini dilakukan dengan rancangan acak kelompok lengkap (RAKL) yang terdiri dari 2 faktor dengan 3 ulangan. Faktor pertama adalah dosis pupuk kasgot yang terdiri dari 5 taraf yaitu K0: kontrol, K1: 500 kg. ha־¹, K2: 1000 kg. ha־¹, K3: 1500 kg. ha־¹, dan K4: 2000 kg.ha־¹ dan faktor kedua dosis zeolit yang terdiri dari 2 taraf yaitu Z0: kontrol dan Z1: 500 kg. ha־¹ Variabel yang diamati yaitu tinggi tanaman, jumlah daun, jumlah anakan, panjang akar, jumlah umbi, bobot basah umbi, bobot kering umbi, bobot kering total umbi, bobot basah tanaman dan bobot kering total tanaman. Hasil penelitian menunjukkan bahwa pemberian pupuk kasgot dosis 1000 kg. ha־¹ ampu meningkatkan variabel tinggi tanaman, jumlah daun, jumlah umbi, bobot basah umbi, bobot kering askip umbi, bobot kering total umbi dan bobot kering total tanaman. Pemberian zeolite meningkatkan beberapa komponen pertumbuhan dan produksi tanaman yaitu : tinggi tanaman,panjang akar, bobot basah umbi, bobot kering askip umbi, berat kering total umbi, berat basah tanaman, dan berat kering total tanaman. Pengaruh interaksi antara pupuk kasgot dan zeolite diperoleh pada variabel jumlah anakan dan jumlah umbi, dengan kombinasi perlakuan terbaik dosis pupuk kasgot 1000 kg. ha־¹ dan zeolit 500 kg.ha־¹.
Penerapan Peraturan Pemerintah No. 23 Tahun 2018 Pada CV Karya Rasa Indonesia
Authors: Maharani Mira , Dewi Kusuma , Wahyuni Iis 
Published: August 2024

Taxes are a source of state financial income collected by gathering funds or money from taxpayers into the state treasury. One tax that significantly contributes to the state is income tax. Among the types of income taxes is the Final Income Tax based on Government Regulation Number 23 of 2018 for MSMEs (Micro, Small, and Medium Enterprises) with a certain gross circulation. The review was conducted at CV. Karya Rasa Indonesia, an MSME engaged in the sale and manufacture of Bogor specialty souvenirs. The purpose of this discussion is to understand the implementation, calculation methods, payment, and reporting of the Final Income Tax based on Government Regulation Number 23 of 2018 as practiced by CV. Karya Rasa Indonesia. The review results at CV. Karya Rasa Indonesia show that the calculation, payment, and reporting of the final income tax for 2021 were in accordance with the applicable tax procedures and regulations in Indonesia. Considering the time frame for the application of Government Regulation Number 23 of 2018 with corporate taxpayers in the form of limited partnerships, it is expected that the company will continue to monitor and follow the development of tax regulations and provisions to avoid miscalculation and tax reporting errors.

Keywords: Tax, Government Regulation No. 23 of 2018, MSMEs