bluuebunny/crossref_metadata_2025_split huggingface dataset:
SOSIALISASI WAWASAN KESEHATAN DASAR PADA SISWA SD MELALUI PROGRAM KULIAH KERJA NYATA INTERNASIONAL (KKN UNIVERISTAS MATARAM-FUKUSHIMA MEDICAL UNIVERSITY JEPANG) DI DESA PUYUNG KABUPATEN LOMBOK TENGAH
Authors: Prasedya Eka Sunarwidhi , Haqiqi Nirwana , Qoriasmadillah Wanda , Fitriani Fitriani , Utami Ni Wayan Putri , Ichfa Muh Syach Maulad , Arrazy Muadz , Tate Kazuma , Shinozuka Miho , Ikunaga Arisa , Miyake Masao , Hazama Akihiro 
Published: June 2024

Di negara berkembang, komplikasi kehamilan yang paling umum terjadi pada wanita hamil adalah anemia. Prevalensi anemia dalam kehamilan yang terjadi di Indonesia masih cukup tinggi termasuk di wilayah Jawa Timur. Permasalahan ibu hamil di Polindes Kaliwining wilayah Puskesmas Rambipuji Jember adalah status anemia tidak terdeteksi pada tiap trimester kehamilan. Kacang hijau mengandung zat besi yang membantu pembentukan eritrosit untuk meningkatkan kadar hemoglobin. Pengabdian kepada masyarakat ini bertujuan untuk memberikan edukasi gizi dan pemanfaatan kacang hijau dalam mencegah anemia dalam kehamilan. Pelaksanaan pengabdian ini menggunakan metode penyuluhan dengan menggunakan pendekatan media video. Selain itu, dilakukan juga pemeriksaan kadar hemoglobin darah pada ibu hamil sebagai deteksi dini anemia. Suplementasi besi diberikan dalam bentuk tablet tambah darah pada ibu hamil. Selain itu, pemberian minuman sari kacang hijau sebagai pelengkap suplementasi besi untuk mencegah anemia dalam kehamilan. Pendekatan edukasi melalui video terbukti efektif dalam meningkatkan pengetahuan ibu hamil sebesar 25% terkait anemia dan manfaat kacang hijau. Kadar hemoglobin darah berdasarkan hasil pemeriksaan dalam kegiatan pengabdian ini didapatkan 2 responden mengalami anemia pada trimester tiga kehamilan.Pemeriksaan Hb secara berkala sangat penting selama masa kehamilan. Kombinasi konsumsi tablet tambah darah dan kacang hijau dapat mengurangi insiden anemia dalam kehamilan.
A COMPARATIVE ANALYSIS OF COMPLIMENTS IN CELEBRITIES’ INSTAGRAM AND TIKTOK COMMENTS
Authors: Fajri Aulia Nur , Sudarwati Emy 
Published: June 2024

The purpose of this research is to examine the complementing strategies employed in celebrity Instagram and TikTok comments, as well as the differences between these strategies. This research used qualitative methods. The researchers selected 150 comments on Instagram and 150 comments on TikTok. Then, the researchers analyzed it using Ye's theory to analyze the compliments strategy and used Manes Wolfson's theory to analyze the syntactic pattern. Furthermore, the researchers compared the use of compliments on Instagram and Tiktok. The findings from this research showed that direct compliments tend to be used on both Instagram and TikTok. The study also discovered seven different types of direct compliments, including NP {is/looks} (really) ADJ; I (really) {like/love} NP; PRO is (really) (a) ADJ NP; You V (really) (a) ADJ NP; You V (NP) (really) ADV; You have (a) (really) ADJ NP; and ADJ NP! the use of form ADJ NP! is more likely to be used on Instagram. Meanwhile, the form NP {is/looks} (really) ADJ is more likely to be used on TikTok.
THE REPRESENTATION OF THE MYTHOLOGICAL TANUKI IN STUDIO GHIBLI’S POM POKO: BARTHESIAN SEMIOTIC ANALYSIS
Authors: Wedhowerti Wedhowerti 
Published: June 2024

Studio Ghibli’s animated film Pom Poko presents the tanuki or raccoon dogs which, according to the Japanese myth, have magical power of impersonating human or shape-lifting. Mythology refers to the study of religious or heroic legends and tales created by particular communities or societies. Having the setting in the 1960s of post-war Japan, this animated film mediates the meaning of the tanuki’s moves in selected scenes. Therefore, Barthesian semiotic model is employed as semiotics itself is concerned with the film and its representation. This research is then aimed at finding out the representation of the tanuki. Employing qualitative method, this research selects six data in the forms of images to analyze. The results yield that the tanuki are the heroes of environmental conservation by struggling and using force for the sake of their environment, jungle, food sources, living territory, and future cubs. Their moves of defending nature represent their ecological terroristic ideology or ecoterrorism.
SELF-ACTUALIZATION IN IWAN SIMATUPANG’S NOVEL ZIARAH
Authors: Manugeren M. 
Published: June 2024

A person should achieve maximum satisfaction in life and achieve balance between physical, emotional, social and spiritual aspects as the manifestation of self-actualization. This research aims to reveal that an individual who experiences a self-actualization process is able to recognize and develop their talents, abilities and values. The entire research is carried out using a qualitative descriptive method to reveal that self-actualization can be used as a guide to achieving harmony between all elements of the environment. In the data collection procedures, all the data with a focus on self-actualzation are gathered from the novel, covering a comprehensive data selection to meet the objectives of the study. The selected data are then sorted out to be conformed with the types of self-actualization as the points of analysis. For the data analysis, deductive frequency method of analysis is applied, going from general to specific analysis. All the types of data needed are classified, coded and interpreted comprehensively based on the focus of the study. The main data source is obtained from the novel above and subsequently from other related references. By using a humanistic psychology approach with the concept of the process of self-understanding which is then generated with the theory of human needs by Abraham Maslow, with a formulation of the levels of human needs starting from the most basic to gaining self-understanding, it is found that the novel contains the concept of self-actualization in the form of free will, responsibility and self-awareness.
Impact of Gliclazide Modified Release or Glimepiride as Add-on Therapy to Metformin on Glycemic and Oxidative Stress Parameters in Type 2 Diabetic Patients
Authors: Fadhel A. Shehab  , Ali L. Jasim2  , Adel Gh. Mohammed  
Published: June 2024

Background: Type 2 diabetes mellitus is a condition characterized by an elevation of oxidative stress, which has been implicated in diabetic progression and its vascular complications.
Aim: Assessing the impact of gliclazide modified release (MR) versus glimepiride on oxidative stress markers, glycemic indices, lipid profile, and estimated glomerular filtration rate in uncontrolled type 2 diabetic patients on metformin monotherapy.
Methods: This was an observational comparative study conducted in Thi-Qar specialized diabetic, endocrine, and metabolism center. Sixty-six patients were randomized into two groups based on the addition of the sulfonylureas (SUs). Group 1 (33 patients) was on gliclazide MR, whereas Group 2 (33 patients) was on glimepiride. The measured oxidative stress markers were reduced glutathione (GSH), superoxide dismutase (SOD), malondialdehyde (MDA), and protein carbonyl (PC) evaluated before and after 16 weeks of SUs addition.
Results: There were significant drops in SOD (P < 0.001), MDA (P < 0.001), and PC (P = 0.001) and a significant increase in GSH (p = 0.029) levels after gliclazide MR add-on therapy. There were significant drops in SOD (P = 0.026) and MDA (P < 0.001) levels with non-significant changes in both GSH (P = 0.214) and PC (P = 0.538) after glimepiride add-on therapy. There was a significant difference in improvement of PC level (P = 0.048) in the gliclazide group compared to the glimepiride group, with a non-significant numerically higher improvement of GSH, SOD, and MDA in gliclazide MR than glimepiride. At the end of the study, there were no significant differences in glycemic control, lipid profile, or eGFR improvement between the two groups.
Conclusion: Glycemic control plays a pivotal role in decreasing oxidative stress. The control of diabetes with the gliclazide-MR-metformin combination reduced oxidative stress more than the glimepiride-metformin combination, indicating its antioxidant property.
Keywords: Oxidative Stress, T2DM, Gliclazide MR, Glimepiride, Metformin.
Synthesis, Molecular Docking Study, Anti-Oxidant and Cytotoxicity Evaluation of New Spiro Six Membered Ring Derivatives of 5-nitro isatin
Authors: Hala Ayad Mohamed Rasheed  , Suaad M. H. Al-Majidi  
Published: June 2024

Spiro-5-nitro isatino six memberd ring (quinazoline-4-one, thiazine-4-one and oxazine-4-one) respectively were produced by a cycloaddition of 5-nitro isatin Schiff bases [1–5] with anthranilic acid, o-mercapto benzoic acid and salicylic acid. 1HNMR and 13CNMR nuclear magnetic resonance spectroscopies, as well as Fourier-transform infrared spectroscopy, were used to identify the structures of the obtained compounds. These spiro-5-nitro isatin are of interest to us due to their potential antioxidant and anticancer properties. The MTT assay ((3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide)) was used to examine in vitro bioactivity testing against breast cancer (MCF-7) cell lines which compound 14 (IC50=79.85, IC50=39) after 24 hours and 48 hours showed good cytotoxicity compared with drug reference tamoxifen. synthesized compounds 6-20 were evaluated for against antioxidant activity by using DPPH assay. In molecular docking, Promising compounds were used to reveal potential cytotoxic activity mechanisms.
Demokrasi dan Kontradiksi-Kontradiksinya, Perspektif Sejarah Filosofis Pierre Rosanvallon
Authors: Dua Mikhael 
Published: June 2024

<strong><em>Abstract: </em></strong><em>This Article discusses on Pierre Rosanvallon’s conceptual history of democracy both as a method to understand the antinomy and the pathology of democracy and as a reflection of the generality of moral politics. For this purpose, the article will consist into three parts. The first one will deal with Rosanvallon’s conceptual history of democracy. The second part will delve into the problem of antinomy and pathology of democracy. And the third part will focus of the search for the normativity which is based on the moral generality. As conclusion, the article will invite the researchers to pay attention to the possibility of searching local wisdom as the clues to build the moral generality which is based on social relationship<strong>. </strong></em>
Surgical infarct volume reduction and functional outcomes in patients with ischemic cerebellar stroke: results from a multicentric retrospective study
Authors: Hernandez-Duran Silvia , Walter Johannes , Behmanesh Bedjan , Bernstock Joshua D. , Czabanka Marcus , Dinc Nazife , Dubinski Daniel , Freiman Thomas M. , Konczalla Juergen , Melkonian Ruzanna , Mielke Dorothee , Mueller Sebastian , Naser Paul , Rohde Veit , Senft Christian , Schaefer Jan Hendrik , Unterberg Andreas , Won Sae-Yeon , Gessler Florian 
Published: June 2024

OBJECTIVE
Recent work on ischemic cerebellar stroke has suggested that the resection of infarcted tissue may lead to improved functional outcomes compared with decompressive surgery alone. Nonetheless, no studies have assessed the extent to which necrotic tissue should be resected or if there are any volumetric thresholds capable of predicting functional outcomes in this patient population. In this study, the authors aimed to determine potential thresholds for volume reduction in ischemic cerebellar stroke in an effort to optimize the management of ischemic cerebellar stroke and, in so doing, improve functional outcomes.

METHODS
This study is a multicentric retrospective study of patients who underwent surgery for the management of ischemic cerebellar stroke. Volumetric analyses of infarcted tissue present on CT scans were performed before and after surgical intervention(s). The final infarct volume (FIV) was computed as a percentage of the initial infarct volume (postoperative infarct volume/preoperative infarct volume × 100). The primary endpoint was functional outcome at 3 months, as determined by the modified Rankin Scale (mRS) score; mRS scores 0–2 were considered as favorable and mRS scores 3–6 as unfavorable. Receiver operating characteristic curves were used to explore the relationship between postoperative infarct volumes and FIV versus mRS score, and Youden’s index was used to estimate potential volumetric thresholds.

RESULTS
A total of 91 patients were included in the study. The mean pre- and postoperative infarct volumes were 45.25 (SD 18.32) cm3 and 29.56 (SD 26.61) cm3, respectively. Patients undergoing necrosectomy, regardless of whether via craniotomy or craniectomy, were more likely to have a favorable outcome at discharge (OR 16.62, 95% CI 2.12–130.33; p = 0.008) and at 3 months (OR 24.12, 95% CI 3.03–192.18; p = 0.003) postoperatively. Postoperative infarct volumes ≤ 17 cm3 yielded a sensitivity of 77% and a specificity of 68% with regard to the prediction of favorable outcome at 3 months. The resection ≥ 50% of infarcted tissue was also predictive of favorable outcomes at 3 months (OR 7.7, 95% CI 2.7–21.8; p < 0.001).

CONCLUSIONS
The reduction of necrotic tissue volumes by at least 50% and/or the reduction of the infarct volume by ≤ 17 cm3 appear to be associated with favorable outcomes in patients with surgically managed ischemic cerebellar strokes.
Hearing preservation outcomes using direct cranial nerve eight and auditory brainstem response neuromonitoring in the resection of vestibular schwannomas
Authors: Sloane Dayna C. , Nuru Mohammed , Pecoraro Nathan C. , Hand Rob , Strelko Oleksandr , Shin William Y. , Russ Adriana , Rajasekhar Rebecca , Jusue-Torres Ignacio , Hadjipanayis Constantinos , Leonetti John P. , Anderson Douglas E. 
Published: June 2024

OBJECTIVE
Advancements in microsurgical technique and technology continue to improve outcomes in patients with skull base tumor. The primary cranial nerve eight monitoring systems used in hearing preservation surgery for vestibular schwannomas (VSs) are direct cranial nerve eight monitoring (DCNEM) and auditory brainstem response (ABR), although current guidelines are unable to definitively recommend one over the other due to limited literature on the topic. Thus, further research is needed to determine the utility of DCNEM and ABR. The authors performed a retrospective cohort study and created an interactive model that compares hearing preservation outcomes based on tumor size in patients receiving ABR+DCNEM and ABR-only monitoring.

METHODS
Twenty-eight patients received ABR+DCNEM and 72 patients received ABR-only monitoring during VS hearing preservation surgery at a single tertiary academic medical center between January 2008 and November 2022. Inclusion criteria consisted of adult patients with a preoperative American Academy of Otolaryngology–Head and Neck Surgery (AAO-HNS) hearing classification of A or B. Tumor size was measured as the maximal medial to lateral length, including the internal auditory canal component.

RESULTS
Overall hearing preservation (word recognition score [WRS] > 0%) was achieved in 31 patients with ABR-only monitoring (43.1%) and in 18 patients with ABR+DCNEM (64.3%). Serviceable hearing preservation (AAO-HNS class A or B) was attained in 19 patients with ABR-only monitoring (26.4%) and in 11 patients with ABR+DCNEM (39.3%). There was no difference in overall hearing preservation between the two groups (p = 0.13). Change in tumor size was not associated with the odds of serviceable hearing preservation for the ABR-only group (p = 0.89); however, for ABR+DCNEM, there was some indication of an interaction between tumor size and the association of ABR+DCNEM versus ABR-only monitoring, with the odds of serviceable hearing preservation at p = 0.089. Furthermore, with ABR+DCNEM, every 0.5-cm increase in tumor size was associated with a decreased odds of serviceable hearing preservation on multivariable analysis (p = 0.05). For both overall and serviceable hearing preservation, a worse preoperative AAO-HNS classification was associated with a decreased odds of preservation (OR 0.43, 95% CI 0.19–0.97, p = 0.042; OR 0.17, 95% CI 0.053–0.55, p = 0.0031, respectively).

CONCLUSIONS
The result of this interactive model study proposes that there may be a higher chance of hearing preservation when using ABR+DCNEM rather than ABR alone for smaller tumors, with that relationship reversing as tumor size increases.
The natural course, treatment outcomes, and long-term prognosis of cervical spinal cord arteriovenous shunts
Authors: Lu Hao-Han , Li Zheng-Song , Li Jing-Wei , Li Gui-Lin , He Chuan , Ye Ming , Hu Peng , Sun Li-Yong , Ma Yong-Jie , Ren Jian , Ling Feng , Zhang Hong-Qi , Yu Jia-Xing , Hong Tao 
Published: June 2024

OBJECTIVE
The highly intricate nature of the cervical spinal cord can cause arteriovenous shunts in these segments that may be associated with heightened clinical risks and treatment complexities. In this article, the authors aimed to provide a comprehensive analysis of the detailed natural course, treatment, and clinical outcomes of cervical spinal cord arteriovenous shunts (SCAVSs) based on the largest cohort to date.

METHODS
Two hundred forty consecutive patients were included. Data on clinical presentation, angioarchitecture, treatment, and follow-up were retrospectively reviewed.

RESULTS
The cohort demonstrated a greater prevalence of acute onset (63.3% vs 36.7%). Spontaneous recovery was observed in 63.7% of patients after onset, with a significantly elevated recovery rate observed among patients experiencing acute onset (72.4% vs 48.9%, p < 0.001). The risks of acute and gradual clinical deterioration after onset was 11.9%/year and 13.4%/year, respectively. Microsurgery was performed in 39.6% of patients, while the remaining 60.4% exclusively underwent embolization. The complete obliteration rate was 65.3% after microsurgery and 21.4% after embolization. The rate of treatment-related deterioration was 14.7% after microsurgery and 6.2% after embolization. After partial treatment, the acute and gradual deterioration rates were 4.1%/year and 6.6%/year, respectively. Lack of spontaneous recovery after onset was an independent predictor of embolization-related deterioration (OR 17.905, p = 0.007) and long-term gradual deterioration after partial treatment (HR 2.325, p = 0.021). After a median follow-up period of 32.55 months, prognosis was unfavorable in 16.7% of patients, with the sole independent risk factor being the absence of spontaneous recovery after onset (OR 2.476, p = 0.018).

CONCLUSIONS
The outcomes of patients with cervical SCAVS were generally favorable, even in patients with only partial obliteration of the lesions. However, patients who did not show a trend toward spontaneous recovery after onset had a significantly elevated risk of unfavorable prognosis, highlighting the need for prompt clinical intervention.
Subventricular zone–associated classification in isocitrate dehydrogenase–wildtype glioblastomas: improved prognostic value through integration of FLAIR with contrast-enhanced imaging
Authors: Zhao Xuzhe , Ren Xiaohui , Li Mingxiao , Jiang Haihui , Li Ming , Wan Haibin , Zhang Yutao , Lin Song , Zhou Dabiao 
Published: June 2024

OBJECTIVE
Controversy surrounds the prognostic value of contrast-enhanced T1-weighted (T1CE) imaging–based subventricular zone (SVZ) classification in isocitrate dehydrogenase (IDH)–wildtype glioblastomas (GBMs). In this study, the authors aimed to assess the potential of incorporating FLAIR imaging into T1CE imaging–based classification for improving prognostic accuracy.

METHODS
A retrospective analysis was conducted on 281 patients with IDH-wildtype GBM. T1CE imaging–based classification was performed, and T2-weighted/FLAIR imaging was integrated to evaluate its prognostic estimation ability. Based on the relationship between the tumors and SVZ, patients were categorized into SVZ+ and SVZ− cohorts based on T1CE and T2-weighted/FLAIR imaging findings. Kaplan-Meier and Cox proportional hazards regression analyses were used to assess progression-free survival (PFS) and overall survival (OS), respectively. Patients were then categorized into three subgroups based on their combined classifications: group 1 (SVZ+ on T1CE and T2-weighted/FLAIR imaging), group 2 (SVZ− on T1CE but SVZ+ on T2-weighted/FLAIR imaging), and group 3 (SVZ− on T1CE and T2-weighted/FLAIR imaging). Subgroup analysis was used to evaluate differences in clinical and molecular factors as well as in prognoses.

RESULTS
The T1CE imaging–based classification failed to stratify OS between SVZ+ and SVZ− cohorts (16.0 vs 20.0 months, p = 0.36). Survival analysis revealed similar prognoses for patients in groups 1 and 2, and patients in group 2 exhibited worse OS compared with those in group 3 (19.0 vs 23.5 months, p = 0.024). Logistic regression identified lower Karnofsky Performance Status (KPS) (p = 0.011), tumor diameter (p = 0.002), and telomerase reverse transcriptase (TERT) promoter mutation (p = 0.003) to be associated with a higher incidence of group 2 GBMs. Additionally, T2-weighted/FLAIR imaging–based classification provided significant prognostic value (17.0 vs 23.5 months p = 0.021) and was found to be an independent prognostic factor in the Cox multivariate analysis (HR 1.79, 95% CI 1.08–2.96; p = 0.024).

CONCLUSIONS
This study underscores the limitations of T1CE imaging–based SVZ-associated classification in predicting prognosis for IDH-wildtype GBMs. The authors therefore propose an integrated approach that involves T2-weighted/FLAIR imaging that can provide improved prognostic ability. Notably, the presence of TERT promoter mutation was identified as a critical factor in nonenhancing tumor infiltration into the SVZ. Further validation through extensive cohort studies is recommended to confirm these findings.
Full-endoscopic lumbar discectomy for lumbar disc herniation in young adults: 199 consecutive cases treated by a single surgeon with a mean 3.7-year follow-up
Authors: Feng Fei , Zhao Rugang , Dong Huajun , Yu Lingjia , Yang Yong , Tang Hai , Liu Xiaoguang , Zhu Bin 
Published: June 2024

OBJECTIVE
Lumbar disc herniation (LDH) is rare in young adults. The present study aimed to evaluate the clinical outcomes of full-endoscopic lumbar discectomy (FELD) for LDH in young adults and to determine the risk factors that predict unfavorable outcomes of FELD for LDH in young adults.

METHODS
A retrospective two-center cohort study was performed between January 2015 and October 2021 at the authors’ institutions. Clinical outcomes were assessed using the visual analog scale (VAS) for low-back pain and leg pain and the Oswestry Disability Index (ODI). The modified Macnab criteria were used to evaluate clinical efficacy at the last follow-up, and the global outcomes were classified into 4 groups, namely excellent, good, fair, and poor. The fair and poor groups were defined as unfavorable outcomes.

RESULTS
One hundred ninety-nine patients were analyzed in this study (mean age 18.5 years, mean BMI 25.1 kg/m2, male/female sex ratio 2.8). The duration from the onset of symptoms to the operation was in general prolonged with age. The VAS and ODI scores significantly improved after surgery. A total of 17 of 195 single-segment cases had unfavorable outcomes based on the modified Macnab criteria. Lateral disc herniation (OR 3.72, 95% CI 1.14–12.12, p = 0.029) and high preoperative VAS score (OR 1.98, 95% CI 1.13–3.46, p = 0.017) were identified as risk factors for unfavorable outcomes after FELD.

CONCLUSIONS
FELD for LDH in young adults is safe and effective. Preoperative VAS score and lateral disc herniation are risk factors of nonfavorable outcomes after surgery and may be a useful index for surgical procedure selection.