bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family Environment, Social Support, and Health‐Related Quality of Life in Adolescents Following Kidney Transplant
Authors: Roberts Emma , Zelikovsky Nataliya 
Published: July 2024

ABSTRACTBackgroundKidney transplantation is the treatment of choice for pediatric end‐stage renal disease. Transplant recipients often have better neurocognitive, academic, and health‐related outcomes. While there is some evidence that health‐related quality of life (HRQOL) improves following kidney transplant, other studies have found adolescent transplant recipients report lower overall HRQOL than healthy peers. Current research has focused on individual‐level factors affecting adjustment to organ transplant, warranting examination of HRQOL from a systems perspective. Family environment and social support contribute to a system of proximal relationships that are crucial in adolescents' development, making them important factors to study in relation to HRQOL post‐transplant.MethodsThe current study utilized archival data of adolescent renal transplant patients who completed surveys about their family environment, social support, and HRQOL during routine transplant clinic visits.ResultsFamily cohesion, as well as social support from parents, classmates, and people in school, were positively correlated with HRQOL. Social support from people in school uniquely predicted variance in HRQOL, beyond the contribution of overall family environment after controlling for demographic factors. Relative to comparable adolescent samples, transplant recipients reported more optimal overall family environment, greater social support from teachers, and lower social support from close friends.ConclusionPsychosocial interventions for adolescent kidney transplant recipients may be enhanced by collaborating with school professionals and further bolstering strengths in the family environment. Kidney transplant recipients may benefit from long‐term intervention, as decreased HRQOL appears to persist years post‐transplant.
One‐pot, easy and scalable synthesis of large‐size short wave length IR emitting PbS quantum dots
Authors: Sahu Umasharan , Prasad Bhagavatula L. V. 
Published: July 2024

AbstractThis study presents a versatile and efficient method to synthesize large‐size lead sulfide (PbS) quantum dots (QDs) that display emission in the short‐wave infrared (SWIR) region, using accessible and stable diethylammonium diethyldithiocarbamate (C2)2DTCA and octylammonium octyldithiocarbamate (C8DTCA) as sulfur sources. As these sulfur sources enable the formation of well‐dispersed, large‐size PbS QDs in a very convenient way, this method can further be taken up for scale‐up studies. Importantly, this approach allows precise control over QD sizes, thereby enhancing their SWIR optical properties. By adjusting the hot injection temperatures and sulfur source concentrations, different synthesis routes are explored, providing flexibility for the desired QD characteristics. The results presented here offer a promising opportunity to leverage the synthesized PbS QDs in applications such as optoelectronics, sensors, and imaging technology.
Relationship commitment regulation: Influencing a partner's commitment to achieve one's commitment goals
Authors: Machia Laura V. , Tan Kenneth , Agnew Christopher R. 
Published: July 2024

AbstractWe introduce a model of relationship commitment regulation, which describes how romantic partners might use empirically‐validated antecedents of commitment level strategically to influence a partner's commitment toward their relationship based on certain commitment goals they have for the relationship. People are generally aware of and relatively accurate with respect to knowing their partner's level of commitment and also have preferences regarding their desired level. We summarize key antecedents of commitment level (i.e., satisfaction level, alternative quality, investment size, future plans, and subjective norms) and then describe how each can be manipulated via relationship maintenance activities to move a partner's commitment level up or down, or maintained at a desired current level. Collectively, the model provides a strategic roadmap for actions one can take to foster desired commitment in one's partner and provides insight into the dyadic processes and outcomes of relationship maintenance.
Association between HLA alleles and haplotypes with age at diagnosis of type 1 diabetes in an admixed Brazilian population: A nationwide study
Authors: Gomes Marília Brito , dos Santos Gilson Costa , de Sousa Azulay Rossana Santiago , Santos Deborah Conte , Silva Dayse Aparecida , Carvalho Paulo Ricardo Vilas Boas , Negrato Carlos Antonio , Porto Luís Cristóvão 
Published: July 2024

To investigate the potential relationship between HLA alleles and haplotypes and the age at diagnosis of type 1 diabetes (T1DAgeD) in an admixed Brazilian population. This nationwide study was conducted in public clinics across 12 Brazilian cities. We collected demographic and genetic data from 1,600 patients with T1D. DNA samples were utilised to determine genomic ancestry (GA) and perform HLA typings for DRB1, DQA1 and DQB1. We explored allele and haplotype frequencies and GA in patients grouped by T1DAgeD categories (<6 years, ≥6–<11 years, ≥11–<19 years and ≥19 years) through univariate and multivariate analyses and primary component analyses. Additionally, we considered self‐reported colour–race and identified a familiar history of T1D in first‐degree relatives. The homozygosity index for DRB1~DQA1~DQB1 haplotypes exhibited the highest variation among T1DAgeD groups, and the percentages of Sub‐Saharan African and European ancestries showed opposite trends in principal component analysis (PCA) analyses. Regarding the association of alleles and haplotypes with T1DAgeD, risk alleles such as HLA‐DQB1*03:02g, ‐DQA1*03:01g, ‐02:01g, DRB1*04:05g and ‐04:02g were more frequently observed in heterozygosity or homozygosity in T1D patients with an early disease onset. Conversely, alleles such as DRB1*07:01g, ‐13:03g, DQB1*06:02g and DQA1*02:01 were more prevalent in older T1D patients. The combination DR3/DR4.5 was significantly associated with early disease onset. However, gender, GA, familiar history of T1D and self‐reported colour–race identity did not exhibit significant associations with the onset of T1D. It is worth noting that the very common risk haplotype DRB1*03:01g~DQA1*05:01g~DQB1*02:01g did not differentiate between T1DAgeD groups. In the admixed Brazilian population, the high‐risk haplotype DRB1*04:05~DQA1*03:01~DQB1*03:02 was more prevalent in individuals diagnosed before 6 years of age. In contrast, the protective alleles DQA1*01:02g, DQB1*06:02g, DRB1*07:01g and DRB1*13:03g and haplotypes DRB1*13:03g~DQA1*05:01g~DQB1*03:01g and DRB1*16:02g~DQA1*01:02g~DQB1*05:02g were more frequently observed in patients diagnosed in adulthood. Notably, these associations were independent of factors such as sex, economic status, GA, familiar history of T1D and region of birth in Brazil. These alleles and haplotypes contribute to our understanding of the disease onset heterogeneity and may have implications for early interventions when detected in association with well‐known genomic risk or protection factors for T1D.
Xanthomonas oryzae pv. oryzicola effector Tal10a directly activates rice OsHXK5 expression to facilitate pathogenesis
Authors: Wang Jiuxiang , Liao Zhouxiang , Jin Xia , Liao Lindong , Zhang Yaqi , Zhang Rongbo , Zhao Xiyao , Qin Huajun , Chen Jianghong , He Yongqiang , Zhuang Chuxiong , Tang Jiliang , Huang Sheng 
Published: July 2024

SUMMARYBacterial leaf streak (BLS), caused by Xanthomonas oryzae pv. oryzicola (Xoc), is a major bacterial disease in rice. Transcription activator‐like effectors (TALEs) from Xanthomonas can induce host susceptibility (S) genes and facilitate infection. However, knowledge of the function of Xoc TALEs in promoting bacterial virulence is limited. In this study, we demonstrated the importance of Tal10a for the full virulence of Xoc. Through computational prediction and gene expression analysis, we identified the hexokinase gene OsHXK5 as a host target of Tal10a. Tal10a directly binds to the gene promoter region and activates the expression of OsHXK5. CRISPR/Cas9‐mediated gene editing in the effector binding element (EBE) of OsHXK5 significantly increases rice resistance to Xoc, while OsHXK5 overexpression enhances the susceptibility of rice plants and impairs rice defense responses. Moreover, simultaneous editing of the promoters of OsSULTR3;6 and OsHXK5 confers robust resistance to Xoc in rice. Taken together, our findings highlight the role of Tal10a in targeting OsHXK5 to promote infection and suggest that OsHXK5 represents a potential target for engineering rice resistance to Xoc.
Diversity and phylogeny of demosponge fauna in the abyssal nodule fields of the eastern Clarion‐Clipperton Zone, Pacific Ocean
Authors: Lim Swee‐Cheng , Wiklund Helena , Bribiesca‐Contreras Guadalupe , Glover Adrian G. , Dahlgren Thomas G. , Tan Koh‐Siang 
Published: July 2024

AbstractMore than 7000 demosponge species have been described to date globally but <2% are known from the abyssal plains, which occupy some 50% of the Earth's surface. The demosponge fauna in the abyssal nodule fields at Clarion‐Clipperton Zone (CCZ) in the Pacific Ocean, a region being explored for potential deep‐sea mining, is a case in point. A total of 21 species belonging to 13 genera in nine families and seven orders were identified from the eastern region of the CCZ, of which most are new to science. They are small in size (<5 mm), with simple skeletons and poor spicule diversity. All ordinal representatives of Demospongiae were utilized to determine taxonomic position of the highly homoplasious tiny demosponges in our molecular phylogenetic analyses. Our results indicated Plenaster craigi, the most common and abundant species in the eastern CCZ, represents a new family, and possibly in a new order. Interestingly, P. craigi and members of the families Polymastiidae and Hamacanthidae, all filter‐feeding demosponge species, are far more abundant in nodule fields than the carnivorous sponges (Cladorhizidae) which were widely known to be the most dominant demosponge group in the abyssal depths. Lastly, it is highly likely that such tiny demosponges are present in other habitats. They might have been overlooked and/or ignored by sponge researchers in the past due to their tiny size and nondescript habitus. These demosponges could be distinct new species, not juveniles or indeterminates and warrant full taxonomic treatment.
Can We Just Play? Internal Validity of Assessing Physiological State With a Semistandardized Kicking Drill in Professional Australian Football
Authors: Arguedas-Soley Adriano , Shushan Tzlil , Murphy Andrew , Poulos Nicholas , Lovell Ric , Norris Dean 
Published: July 2024

Purpose: To examine associations between exercise heart rate (HRex) during a continuous-fixed submaximal fitness test (CF-SMFT) and an intermittent-variable protocol (semistandardized kicking drill [SSD]) in Australian Football athletes, controlling for external intensities, within-session scheduling, and environmental conditions. Methods: Forty-four professional male Australian Football athletes (22.8 [8.0] y) were monitored over 10 sessions involving a 3-minute CF-SMFT (12 km·h−1) as the first activity and a SSD administered 35.7 (8.0) minutes after the CF-SMFT. Initial heart rate and HRex were collected, with external intensities measured as average velocity (in meters per minute) and average acceleration–deceleration (in meters per second squared). Environmental conditions were sampled. A penalized hierarchical linear mixed model was tuned for a Bayesian information criterion minima using a 10-fold cross-validation, with out-of-sample prediction accuracy assessed via root-mean-squared error. Results: SSD average acceleration–deceleration, initial heart rate, temperature, and ground hardness were significant moderators in the tuned model. When model covariates were held constant, a 1%-point change in SSD HRex associated with a 0.4%-point change in CF-SMFT HRex (95% CI, 0.3–0.5). The tuned model predicted CF-SMFT HRex with an average root-mean-squared error of 2.64 (0.57) over the 10-fold cross-validation, with 74% and 86% of out-of-sample predictions falling within 2.7%-points and 3.7%-points, respectively, from observed values, representing the lower and upper limits for detecting meaningful changes in HRex according to the documented typical error. Conclusions: Our findings support the use of an SSD to monitor physiological state in Australian Football athletes, despite varied scheduling within session. Model predictions of CF-SMFT HRex from SSD HRex closely aligned with observed values, considering measurement imprecision.
Effectiveness of Platelet-Rich Plasma in Reducing Pain and Increasing Function After Acute Lateral Ankle Sprain: A Critically Appraised Topic
Authors: Frey Erin , Brown Christopher D. , Tripp Brady 
Published: July 2024

Clinical Scenario: Ankle sprains are one of the most common injuries in athletics, and many lead to recurrent sprains, chronic ankle instability, and persistent symptoms. Treatment improvements are needed. Platelet-rich plasma (PRP) involves formulating autologous plasma with higher platelet concentration to be injected in the desired tissue. There is currently high-quality evidence supporting the use of PRP with lateral epicondylitis and knee osteoarthritis to accelerate the healing process and decrease pain. Clinical Question: Does the injection of PRP relieve pain faster and improve function compared with no injection or placebo in patients with a lateral ankle sprain? Summary of Key Findings: A computerized search yielded 191 studies; of these, 3 studies fit the inclusion and exclusion criteria. PRP injection reduces pain and increases function after lateral ankle sprain 5 to 8 weeks after intervention. Clinical Bottom Line: The use of PRP after lateral ankle sprain to decrease pain and increase function is supported with moderate evidence. Strength of Recommendation: Based on the Strength of Recommendation Taxonomy, evidence from the included studies is considered as level B, reflecting limited quality patient-oriented evidence.
Hierarchical multi-task deep learning-assisted construction of human gut microbiota reactive oxygen species-scavenging enzymes database
Authors: Yan Yueyang , Shi Zhanpeng , Zhang Yongrui 
Published: July 2024

ABSTRACT

In the process of oxygen reduction, reactive oxygen species (ROS) are generated as intermediates, including superoxide anion (O
2−
), hydrogen peroxide (H
2
O
2
), and hydroxyl radicals (OH
−
). ROS can be destructive, and an imbalance between oxidants and antioxidants in the body can lead to pathological inflammation. Inappropriate ROS production can cause oxidative damage, disrupting the balance in the body and potentially leading to DNA damage in intestinal epithelial cells and beneficial bacteria. Microorganisms have evolved various enzymes to mitigate the harmful effects of ROS. Accurately predicting the types of ROS-scavenging enzymes (ROSes) is crucial for understanding the oxidative stress mechanisms and formulating strategies to combat diseases related to the “gut–organ axis.” Currently, there are no available ROSes databases (DBs). In this study, we propose a systematic workflow comprising three modules and employ a hierarchical multi-task deep learning approach to collect, expand, and explore ROSes-related entries. Based on this, we have developed the human gut microbiota ROSes DB (
http://39.101.72.186/
), which includes 7,689 entries. This DB provides user-friendly browsing and search features to support various applications. With the assistance of ROSes DB, various communication-based microbial interactions can be explored, further enabling the construction and analysis of the evolutionary and complex networks of ROSes DB in human gut microbiota species.

IMPORTANCE
Reactive oxygen species (ROS) is generated during the process of oxygen reduction, including superoxide anion, hydrogen peroxide, and hydroxyl radicals. ROS can potentially cause damage to cells and DNA, leading to pathological inflammation within the body. Microorganisms have evolved various enzymes to mitigate the harmful effects of ROS, thereby maintaining a balance of microorganisms within the host. The study highlights the current absence of a ROSes DB, emphasizing the crucial importance of accurately predicting the types of ROSes for understanding oxidative stress mechanisms and developing strategies for diseases related to the “gut–organ axis.” This research proposes a systematic workflow and employs a multi-task deep learning approach to establish the human gut microbiota ROSes DB. This DB comprises 7,689 entries and serves as a valuable tool for researchers to delve into the role of ROSes in the human gut microbiota.
Barriers and facilitators of habit building for long-term adherence to antihypertensive therapy among people with hypertensive disorders in Los Angeles, California: a qualitative study
Authors: Ghai Ishita , Palimaru Alina , Ebinger Joseph E , Barajas Denisse , Vallejo Rocio , Morales Michelle , Linnemayr Sebastian 
Published: July 2024

ObjectivesThe aim of this study was to a) explore barriers and facilitators associated with medication-taking habit formation, and b) elicit feedback on the components of an intervention designed to help form strong habits for long-term medication adherence.DesignThe study design was qualitative; we conducted semistructured interviews between September 2021 and February 2022.SettingThe interviews were conducted online, with 27 participants recruited at the Cedars-Sinai Medical Center in Los Angeles, California.ParticipantsA purposive sample of 20 patients who were over 18 years of age, had been diagnosed with hypertensive disorder (or reported high blood pressure; >140/90 mm Hg) and who were prescribed antihypertensive therapy at the time of recruitment, along with seven providers were interviewed.ResultsContextual factors included frequent changes to prescription for regimen adjustment, and polypharmacy. Forgetfulness, perceived need for medication, and routine disruptions were identified as possible barriers to habit formation. Facilitators of habit formation included identification of stable routines for anchoring, planning, use of external reminders (including visual reminders) and pillboxes for prescription management, and extrinsic motivation for forming habits. Interestingly, experiencing medication side effects was identified as a possible barrier and a possible facilitator of habit formation. Feedback on study components included increasing text size, and visual appeal of the habit leaflet; and imparting variation in text message content and adjusting their frequency to once a day. Patients generally favoured the use of conditional financial incentives to support habit formation.ConclusionThe study sheds light on some key considerations concerning the contextual factors for habit formation among people with hypertension. As such, future studies may evaluate the generalisability of our findings, consider the role of visual reminders in habit formation and sustenance, and explore possible disruptions to habits.Trial registration numberNCT04029883.
‘The unexpected journey’: a qualitative interview study exploring patient and health professionals experiences of participating in the knee arthroplasty versus joint distraction study (KARDS)
Authors: Arnold Susanne , Pandit Hemant , Croft Julie , Stocken Deborah D , Ellard David R 
Published: July 2024

ObjectiveThe aim of the knee arthroplasty versus joint distraction (KARDS) randomised trial was to investigate whether knee joint distraction (KJD) is non-inferior to knee arthroplasty, also known as knee replacement (KR). Here we report the findings from qualitative interviews that were part of the planned KARDS process evaluation.Design and methodsSemi-structured qualitative interviews with staff and participants in secondary care. Data were analysed using thematic content analysis.FindingsWe were unable to complete the full-planned KARDS process evaluation as recruitment to the trial was closed early but key common themes emerged.Eleven members of staff were interviewed from two KARDS sites (eight initial interviews just after site opening and three follow-up interviews at 12 months). Eleven KARDS participants (six KR and five KJD) were interviewed. One overarching theme emerged: ‘An unexpected journey’. This incorporated subthemes including ‘an important research question’, ‘a roller coaster ride’, ‘lessons learnt’, ‘managing expectations’ and ‘a slow recovery’. These encapsulate experiences of both staff and participants.ConclusionThe information that we were able to collect highlights that providing adequate and comprehensive information about all aspects of treatment including estimated timelines of recovery are essential in clinical trials of novel interventions. Incorporating a comprehensive rehabilitation package following KJD was a key learning. Process evaluations in these complex trials are essential to determine issues as early as possible so appropriate changes can be made to ensure participants have a smooth journey through the trial experience.Trial registration numberISRCTN14879004.
Background incidence rates of health outcomes of interest for COVID-19 vaccine safety monitoring in a US population: a claims database analysis
Authors: Banga Sonja , Khromava Alena , Serradell Laurence , Chabanon Anne-Laure , Pan Chunshen , Estevez Irisdaly , Schilsky Samantha , Kreisberg Hannah 
Published: July 2024

ObjectiveTo evaluate background incidence rates of 59 health outcomes of interest (HOI) in a diverse population, including important subpopulations, during the pre-COVID-19 era (1 January 2017–31 December 2019) and the COVID-19 era (1 March 2020–31 December 2020), before the introduction of COVID-19 vaccines.DesignObservational retrospective cohort study. Annual incidence rates and 95% confidence intervals (CIs) of HOIs were estimated for each population of interest, stratified by: age, sex, age and sex and seasonality.Data sourceOptum’s de-identified Clinformatics Data Mart Database (CDM).ParticipantsIndividuals from the US general population and four subgroups of interest: influenza-vaccinated, paediatric (<18 years of age), elderly (≥65 years of age) and pregnant women.ResultsDuring the COVID-19 era, the incidence of several cardiac conditions, coagulation disorders and acute liver injury increased across all populations assessed while the rates of some dermatological and neurological HOIs decreased relative to the pre-COVID-19 era. The incidence of acute respiratory distress syndrome (ARDS) varied considerably by subgroup: among the elderly, it decreased annually during the pre-COVID-19 era but peaked during the COVID-19 era; among pregnant women, it slightly increased annually during the pre-COVID-19 era and substantially increased during the COVID-19 era; among paediatrics, it decreased annually over the entire study. The incidence of the majority of HOIs increased with age, but were generally comparable between sexes with few exceptions. Cardiac, gastrointestinal, neurological and haematological HOIs, along with acute kidney injury and ARDS, were more common in males, whereas several immunological HOIs and chilblain-like lesions were more common in females. Pregnancy-related HOIs did not increase during the COVID-19 era, except for spontaneous abortions which increased annually over the entire study.ConclusionThese observations help contextualise fluctuations in background rates of adverse events noted during the COVID-19 era, and provide insight on how their use may impact safety surveillance for other vaccines.