bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study into the reshaping process of large reservoir banks using remote sensing
Authors: Stepanova M. V. , Ekzaryan V. N. 
Published: August 2024

Background. During the first 10—20 years after the creation of large reservoirs, the process of processing of coastal territories is activated, which leads to the loss of land resources, has a negative impact on the existing coastal infrastructure and changes in the depth of the reservoir as a result of activation of the process of rock accumulation, destruction of coastal slopes. Shoreline retreat is 10—15 meters per year. The paper considers the process of recycling of reservoir banks on the example of the Volgograd reservoir.Aim. Development of a methodology for studying and forecasting the process of reshaping of reservoir banks using remote sensing.Materials and methods. The data of 1980—1990 on the actual magnitude of bank reprocessing of the Volgograd reservoir were collected, processed and analyzed, and the coastal territory was typified. It is proposed to use remote sensing materials to obtain the values of coastal overbanking for the period from the 1990s to the present time. Forecasting of the process of reformation of reservoir banks is carried out on the basis of application of mathematical statistics methods.Results. On the basis of solving the set tasks, a universal new methodology for studying and forecasting reservoir bank reformation was proposed. The methodology was tested on the materials of the Volgograd reservoir.Conclusion. The proposed new methodology makes it possible to obtain data on the dynamics of the Volgograd reservoir bank reformation process and to make a forecast for the next 10 years. This methodology can be used to study the process of bank reformation of large reservoirs.
تأثير تمرينات خاصة بدلالة التغذية الراجعة الصورية في اتقان بعض المهارات الكشفية لطلاب قسم التربية البدنية وعلوم الرياضة
Authors: Asst. Lec.Rawih Youssef Abdel Ali  
Published: August 2024

الملخص
يهدف البحث إلى معرفة تأثير تمرينات خاصة بدلالة التغذية الراجعة الصورية في اتقان بعض المهارات الكشفية، والتعرف على الافضلية بين مجموعتي البحث التجريبية والضابطة. ولقد تم استعمال المنهج التجريبي لملاءمته طبيعة البحث. وقد اُجري البحث على طلاب السنة الدراسية الثالثة بقسم التربية البدنية وعلوم الرياضة/كلية التربية الاساسية للعام الدراسي (2022-2023) بوصفهم مجتمعاً للبحث والبالغ عددهم (146) طالبا وطالبة موزعين على خمس شعب دراسية هي(أ-ب-ج-د-ه) تم اختيار عينة البحث بالطريقة العشوائية (القرعة) من مجتمع الأصل ، مثلوا الشعبتين(ج ، ه) على التوالي، حيث قسموا إلى مجموعتين تجريبية وضابطة بواقع (15) طالباً للمجموعة التجريبية التي تدرس وفق(التغذية الراجعة الصورية ) و(15) طالباً للمجموعة الضابطة التي تدرس وفق(الاسلوب التقليدي) ، تم إعداد وحدات تعليمية في اتقان المهارات الكشفية بالفصل الدراسي الثاني لعام (2022/2023) تدريسهما على ضوء محتوى المنهج المقرر. واستغرق تنفيذ البرنامج (5) أسابيع بواقع وحدة تعليمية واحدة في الأسبوع الواحد وبعد الانتهاء من تنفيذها تم إجراء الاختبارات البعدية وجمع البيانات ومعالجتها بالوسائل الإحصائية المناسبة.
Prevenção dos problemas associados ao abuso de álcool em adolescentes
Authors: Matos Paulo Jorge de Almeida , Silva Junior Firmino Lopes da , Campos Márcio Alexandre de Melo , Silva Erika de Nazaré Rodrigues da , Tavares Paula Guimarães Brito Costa 
Published: August 2024

Objetivos: Identificar estratégias para prevenir os problemas associados ao abuso de álcool em adolescentes, e explorar quais as intervenções de enfermagem para a prevenção dos danos associados ao abuso de álcool. Metodologia: Revisão Integrativa da Literatura (RIL), baseada em estudos primários, quantitativos e observacionais, obtidos através dos motores de busca PubMed, B-On, e das bases de dados Medline e CINAHL. Para a realização da pesquisa utilizámos o método PICOD, selecionamos sete artigos publicados entre 2019 e 2023. Resultados: Os estudos analisaram a eficácia de diferentes intervenções na redução do consumo de álcool entre adolescentes, destacando a importância de implementar programas de prevenção baseados em evidências nas escolas. Tais programas abordam fatores de risco específicos e utilizam estratégias adequadas ao contexto. A prevenção seletiva direcionada à personalidade, como o programa PreVenture, demonstrou efeitos duradouros na redução dos danos relacionados ao consumo de álcool ao longo de vários anos. Esses resultados sublinham a necessidade contínua de investir em iniciativas preventivas para reduzir os impactos negativos do consumo de álcool entre os jovens. Conclusão: É pertinente abordar precocemente o tema do abuso de álcool na adolescência, através de estratégias de prevenção eficazes. É crucial envolver não apenas os adolescentes, mas também as suas famílias, encarregados de educação e toda a comunidade educativa para um maior impacto significativo.
Influence of inflammation on the expression of microRNA-140 in extracellular vesicles from 2D and 3D culture models of synovial-membrane-derived stem cells
Authors: Pfeifer João Pedro Hübbe , Stievani Fernanda de Castro , Fernandes Célio J. da Costa , Rosa Gustavo dos Santos , Apolonio Emanuel Vitor Pereira , Rossi Mariana Correa , Zambuzzi Willian Fernando , Alves Ana Liz Garcia 
Published: August 2024

BackgroundIn osteoarthritis (OA), articular homeostasis is regulated by microRNA-140 that inhibits ADAMTS-5, an enzyme that cleaves aggrecan and stimulates the synthesis of other inflammatory mediators. This study aims to evaluate the expression of microRNA-140 in extracellular vesicles (EVs) derived from equine synovial-membrane-derived mesenchymal stem cells (eqSMMSCs) cultured in monolayer (2D) and three-dimensional (3D) culture models under an in vitro inflammatory environment.MethodsFour experimental groups of eqSMMSC cultures were defined for isolation of the EVs. The 2D and 3D control groups were cultured in a conventional cell culture medium, while the 2D-OA and 3D-OA treatment groups were exposed to an OA-like medium containing IL-1β and TNFα. The culture media samples were collected at 24 h, 72 h, and 120 h time points for EV isolation and characterization using nanoparticle tracking analysis (NTA) and transmission electron microscopy (TEM). Reverse transcription quantitative polymerase chain reaction was employed to assess the expressions of microRNA-140 in both the cells and EVs. All statistical analyses were conducted at the 5% significance level.ResultsEncapsulation of the eqSMMSCs protected the cells from the inflammatory media compared to the monolayer cultures. EVs were found in higher concentrations in the 3D-OA cultures. Additionally, higher expressions of microRNA-140 were observed in the cells of the 3D-OA group at 24 and 72 h, whereas microRNA-140 expressions in the EVs were higher in the 3D group at 72 h and in the 2D-OA group at 120 h (p &lt; 0.001). However, the 3D-OA culture showed higher expression of the mRNA Adamts5 in the EVs at 120 h.ConclusionThe responses of the eqSMMSCs to inflammatory stimuli involve intracellular expression of microRNA-140 and its subsequent transportation via the EVs, with quicker responses observed in the 3D than 2D cultures. This study sheds light on the behaviors of stem cells in restoring homeostasis in osteoarthritic joints.
Study on InSAR deformation information extraction and stress state assessment in a railway tunnel in a plateau area
Authors: Lyu Baihang , Liu Bo , Xie Binfu , Xiao Hairong , Liu Xing , Zhang Ziwen , Li Yang , Huang Xiameng , Shi Fangzhe 
Published: August 2024

Introduction: The study proposes a method for evaluating stress distribution in high-altitude Tibetan Plateau railway tunnels using high-precision radar satellite time-series interferometric synthetic aperture radar technology.Methods: To effectively monitor and prevent geological hazards during the construction process, this method i employed, as it serves as a component of advanced geological prediction and surrounding rock deformation monitoring technology for high-altitude tunnels, particularly in the Dongelu Tunnel of the China–Tibet Railway. The study utilizes time-series interferometric synthetic aperture radar to obtain deformation information for Dongelu Tunnel area between 2022 and 2023 from Sentinel- 1A orbit images. This quantitatively investigates the upper mountain body and line-of-sight direction along the tunnel. The deformation characteristics are correlated with high-frequency and high-precision automated vertical displacement monitoring results, determining the spatiotemporal distribution of tunnel deformation. In this study, a model that determines the vertical stress state of the Dongelu Tunnel under loading near the entrance and evaluates its health status was established.Results: The results show that the surface deformation of the mountain above the tunnel axis develops slowly and is relatively small, with a maximum vertical deformation rate of 1–3 mm/year. The average stress on the tunnel arch is 5.54 MPa, with a fluctuation range of 0.01 MPa. Temporal Q9 changes in various parts of the tunnel are periodic, with maximum fluctuations observed in December 2022. The study reveals inconsistent surface settlement of the tunnel arch and mountain above it, causing minor vertical stress changes. As the tunnel construction progresses, vertical stress variation shows periodicity because of an initial imbalance in internal stress within the mountain. Stress fluctuations near the tunnel entrance occur during the initial excavation phase, gradually diminishing as the project progresses and internal stress stabilizes.Discussion: The proposed tunnel monitoring and stability assessment method can reduce its impact on engineering construction and provide guidance for advanced geological prediction.
A nomogram based on inflammation and nutritional biomarkers for predicting the survival of breast cancer patients
Authors: Wei Caibiao , Ai Huaying , Mo Dan , Wang Peidong , Wei Liling , Liu Zhimin , Li Peizhang , Huang Taijun , Liu Miaofeng 
Published: August 2024

BackgroundWe aim to develop a new prognostic model that incorporates inflammation, nutritional parameters and clinical-pathological features to predict overall survival (OS) and disease free survival (DFS) of breast cancer (BC) patients.MethodsThe study included clinicopathological and follow-up data from a total of 2857 BC patients between 2013 and 2021. Data were randomly divided into two cohorts: training (n=2001) and validation (n=856) cohorts. A nomogram was established based on the results of a multivariate Cox regression analysis from the training cohorts. The predictive accuracy and discriminative ability of the nomogram were evaluated by the concordance index (C-index) and calibration curve. Furthermore, decision curve analysis (DCA) was performed to assess the clinical value of the nomogram.ResultsA nomogram was developed for BC, incorporating lymphocyte, platelet count, hemoglobin levels, albumin-to-globulin ratio, prealbumin level and other key variables: subtype and TNM staging. In the prediction of OS and DFS, the concordance index (C-index) of the nomogram is statistically greater than the C-index values obtained using TNM staging alone. Moreover, the time-dependent AUC, exceeding the threshold of 0.7, demonstrated the nomogram’s satisfactory discriminative performance over different periods. DCA revealed that the nomogram offered a greater overall net benefit than the TNM staging system.ConclusionThe nomogram incorporating inflammation, nutritional and clinicopathological variables exhibited excellent discrimination. This nomogram is a promising instrument for predicting outcomes and defining personalized treatment strategies for patients with BC.
Association of immune evasion in myeloid sarcomas with disease manifestation and patients’ survival
Authors: Bauer Marcus , Monecke Astrid , Hackl Hubert , Wilfer Andreas , Jaekel Nadja , Bläker Hendrik , Al-Ali Haifa Kathrin , Seliger Barbara , Wickenhauser Claudia 
Published: August 2024

IntroductionMyeloid sarcomas (MS) comprise rare extramedullary manifestations of myeloid neoplasms with poor patients’ outcome. While the clinical relevance of the tumor microenvironment (TME) is well established in many malignancies, there exists limited information in MS. MethodsThe expression of the human leukocyte antigen class I (HLA-I) antigens, HLA-I antigen processing and presenting machinery (APM) components and the composition of the TME of 45 MS and paired bone marrow (BM) samples from two independent cohorts were assessed by immunohistochemistry, multispectral imaging, and RNA sequencing (RNAseq).ResultsA significant downregulation of the HLA-I heavy chain (HC; 67.5%) and ß2-microglobulin (ß2M; 64.8%), but an upregulation of HLA-G was found in MS compared to BM samples, which was confirmed in a publicly available dataset. Moreover, MS tumors showed a predominantly immune cell excluded TME with decreased numbers of tissue infiltrating lymphocytes (TILs) (9.5%) compared to paired BM (22.9%). RNAseq analysis of a subset of 10 MS patients with preserved and reduced HLA-I HC expression revealed 150 differentially expressed genes and a significantly reduced expression of inflammatory response genes was found in samples with preserved HLA-I expression. Furthermore, low HLA-I expression and low TIL numbers in the TME of MS cases were linked to an inferior patients’ outcome.DiscussionThis study demonstrated a high prevalence of immune escape strategies in the pathogenesis and extramedullary spread of MS, which was also found in patients without evidence of any BM pathology, which yields the rational for the development of novel individually tailored therapies for MS patients.
Establishment of a chemokine-based prognostic model and identification of CXCL10+ M1 macrophages as predictors of neoadjuvant therapy efficacy in colorectal cancer
Authors: Tuersun Abudumaimaitijiang , Huo Jianting , Lv Zeping , Zhang Yuchen , Chen Fangqian , Zhao Jingkun , Feng Wenqing , Xu Zhuoqing , Mao Zhihai , Xue Pei , Lu Aiguo 
Published: August 2024

BackgroundAlthough neoadjuvant therapy has brought numerous benefits to patients, not all patients can benefit from it. Chemokines play a crucial role in the tumor microenvironment and are closely associated with the prognosis and treatment of colorectal cancer. Therefore, constructing a prognostic model based on chemokines will help risk stratification and providing a reference for the personalized treatment.MethodsEmploying LASSO-Cox predictive modeling, a chemokine-based prognostic model was formulated, harnessing the data from TCGA and GEO databases. Then, our exploration focused on the correlation between the chemokine signature and elements such as the immune landscape, somatic mutations, copy number variations, and drug sensitivity. CXCL10+M1 macrophages identified via scRNA-seq. Monocle2 showed cell pseudotime trajectories, CellChat characterized intercellular communication. CytoTRACE analyzed neoadjuvant therapy stemness, SCENIC detected cell type-specific regulation. Lastly, validation was performed through multiplex immunofluorescence experiments.ResultsA model based on 15 chemokines was constructed and validated. High-risk scores correlated with poorer prognosis and advanced TNM and clinical stages. Individuals presenting elevated risk scores demonstrated an increased propensity towards the development of chemotherapy resistance. Subsequent scRNA-seq data analysis indicated that patients with higher presence of CXCL10+ M1 macrophages in tumor tissues are more likely to benefit from neoadjuvant therapy.ConclusionWe developed a chemokine-based prognostic model by integrating both single-cell and bulk RNA-seq data. Furthermore, we revealed epithelial cell heterogeneity in neoadjuvant outcomes and identified CXCL10+ M1 macrophages as potential therapy response predictors. These findings could significantly contribute to risk stratification and serve as a key guide for the advancement of personalized therapeutic approaches.
Metabolic profiling of idiopathic pulmonary fibrosis in a mouse model: implications for pathogenesis and biomarker discovery
Authors: Zhang Yu-zhu , Jia Xiu-juan , Xu Wen-juan , Ding Xiao-qian , Wang Xiao-meng , Chi Xiao-sa , Hu Yi , Yang Xiao-hui 
Published: August 2024

BackgroundAlterations in metabolites and metabolic pathways are thought to be important triggers of idiopathic pulmonary fibrosis (IPF), but our lack of a comprehensive understanding of this process has hampered the development of IPF-targeted drugs.MethodsTo fully understand the metabolic profile of IPF, C57BL/6 J male mice were injected intratracheally with bleomycin so that it could be used to construct a mouse model of IPF, and lung tissues from 28-day and control IPF mice were analyzed by pathology and immunohistochemistry. In addition, serum metabolites from IPF mice were examined using LC-ESI-MS/MS, and the differential metabolites were analyzed for KEGG metabolic pathways and screened for biomarkers using machine learning algorithms.ResultsIn total, the levels of 1465 metabolites were detected, of which 104 metabolites were significantly altered after IPF formation. In IPF mouse serum, 52% of metabolite expression was downregulated, with lipids (e.g., GP, FA) and organic acids and their derivatives together accounting for more than 70% of the downregulated differentially expressed metabolites. In contrast, FA and oxidised lipids together accounted for 60% of the up-regulated differentially expressed metabolites. KEGG pathway enrichment analyses of differential metabolites were mainly enriched in the biosynthesis of unsaturated fatty acids, pentose phosphate pathway, and alanine, aspartate, and glutamate metabolism. Seven metabolites were screened by machine learning LASSO models and evaluated as ideal diagnostic tools by receiver operating characteristic curves (ROCs).DiscussionIn conclusion, the serum metabolic disorders found to be associated with pulmonary fibrosis formation will help to deepen our understanding of the pathogenesis of pulmonary fibrosis.
Time to recovery from moderate acute malnutrition and its predictors among children aged 6–59 months in Fedis Woreda, East Hararghe Zone, Eastern Ethiopia
Authors: Melaku Berhanu , Gebremichael Berhe , Negash Belay , Kitessa Monas , Kassa Obsan , Dereje Jerman , Kefelegn Reta , Firdisa Dawit 
Published: August 2024

BackgroundAcute malnutrition is a major global public health problem, particularly in low-and middle-income countries. A targeted supplementary feeding program is an approach recommended to address moderate acute malnutrition in food-insecure settings. Preventing and treating moderate acute malnutrition requires identifying factors shown to affect the treatment outcome and duration of stay on treatment. This study aimed to determine the time to recovery from moderate acute malnutrition and its predictors among children aged 6–59 months in Fedis Woreda East Hararghe Zone, Eastern Ethiopia, from January 1 to December 31, 2022.MethodsA facility-based retrospective cohort study was conducted on 567 children with moderate acute malnutrition in Fedis Woreda, East Hararghe Zone, eastern Ethiopia. A multi-stage sampling technique was employed, and data was collected using a structured checklist. Data were extracted from randomly selected records after obtaining ethical clearance. Data were cleaned, coded, entered into EpiData 4.6, and analyzed using STATA/SE version 14. Descriptive statistics and analytic analysis schemes, including bivariable and multivariable Cox proportional hazards models, were conducted, and finally, statistical significance was considered at p &lt; 0.05.ResultsThe overall median time to recovery was 16 weeks. The major predicting factors for time to recovery among children aged 6–59 months were admission with a mid-upper arm circumference of 12.1–12.4 centimeters (AHR = 1.02, 95% CI: 1.01–1.19), access to transportation to facilities (AHR = 0.62, 95% CI: 0.36–0.81), children using specialized nutritious foods (RUSF; AHR = 1.96, 95% CI: 1.36–3.11), and children who had diarrhea (AHR = 0.4, 95% CI: 0.31–0.71).ConclusionThe study found a median recovery time of 16 weeks for children with targeted supplementary feeding. Significant predictors included admission with a MUAC of 12.1–12.4 centimeters, transportation access, RUSF use, and the presence of diarrhea. These findings highlighted the importance of these factors in determining and improving recovery from moderate-acute malnutrition.
Simulation model to assess the validity of the clinical portfolio diet score used in the PortfolioDiet.app for dietary self-tracking: a secondary analysis of a randomized controlled trial in hyperlipidemic adults
Authors: Kavanagh Meaghan E. , Glenn Andrea J. , Chiavaroli Laura , Morgan Gloria A. , Josse Robert G. , Malik Vasanti S. , Marinangeli Christopher P. F. , Kendall Cyril W. C. , Jenkins David J. A. , Sievenpiper John L. 
Published: August 2024

IntroductionThe Portfolio Diet combines cholesterol-lowering plant foods for the management of cardiovascular disease risk. However, the translation of this dietary approach into clinical practice necessitates a user-friendly method for patients to autonomously monitor their adherence.ObjectiveThis study aimed to develop and validate the clinical-Portfolio Diet Score (c-PDS) as a food-based metric to facilitate self-tracking of the Portfolio Diet.MethodsUsing a simulation model to estimate the c-PDS, the validity was assessed in a secondary analysis of a completed trial of the Portfolio Diet in 98 participants with hyperlipidemia over 6 months. Concurrent and predictive validity of the estimated c-PDS were assessed against the reference measure (weighed 7-day diet records) and concomitant changes in LDL-C from baseline to 6 months. Bland–Altman analysis was used to assess the limits of agreement between the two methods.ResultsThe c-PDS was positively correlated with dietary adherence as measured using the 7-day diet records (r = 0.94, p &lt; 0.001). The c-PDS was negatively correlated with change in LDL-C (r = −0.43, p &lt; 0.001) with a 1-point increase in the c-PDS being associated with a − 0.04 mmol/L (CI:−0.06,−0.03; p &lt; 0.001) or a 1.09% reduction in LDL-C. Visual evaluation of the Bland–Altman plots showed reasonable agreement.ConclusionThese findings indicate good validity of the c-PDS for primary prevention in adults with hyperlipidemia. The predictive validity findings have informed the goals and messaging within the PortfolioDiet.app, a digital health application for delivering the Portfolio Diet. Future research will assess the effectiveness of the intended combination of the c-PDS and the PortfolioDiet.app in supporting behavior change.