bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guest‐Induced 2‐D Metallopolycapsular Networks Based on a 1,3‐Alternate Calix[4]arene Derivative
Authors: Lee Eunji , Ju Huiyeong , Kang Youngjin , Lee Shim Sung , Park Ki‐Min 
Published: March 2015

AbstractSolvothermal reactions of the calix[4]arene tetraacetic acid (H4CTA) with zinc nitrate in the presence of α,ω‐diaminoalkanes afford two‐dimensional metallopolycapsular networks of the formula {[Me2NH2]2[G@(Zn2(CTA)2)]⋅(DMF)2⋅(H2O)4}n (G=+NH3–(CH2)n–NH3+, n=2, 3, 4; DMF=N,N‐dimethylformamide). These metallopolycapsular networks are built up of metallocapsules that consist of two CTA and two ZnII ions. Short alkanediyldiammonium (+NH3–(CH2)n–NH3+, n=2, 3, 4) guest ions are accommodated in each capsule of the metallopolycapsular network through a variety of supramolecular interactions. The thermal behaviours and the solid‐state photoluminescent properties of these complexes were also investigated.
An Alternative to the Sandmeyer Approach to Aryl Iodides
Authors: Hu Bao , Miller William H. , Neumann Kiel D. , Linstad Ethan J. , DiMagno Stephen G. 
Published: March 2015

AbstractIodoarenes are important synthons for a wide range of organic transformations. Here we report a general strategy to prepare singly iodinated electron‐rich aromatic compounds through the intermediacy of diaryliodonium salts. This process, which incorporates a phase separation that greatly simplifies product purification, is an attractive replacement for the Sandmeyer approach to iodoarenes that are otherwise difficult to access.
Sinus of Valsalva Aneurysms: Review of the Literature and an Update on Management
Authors: Weinreich Michael , Yu Pey‐Jen , Trost Biana 
Published: March 2015

ABSTRACTSinus of Valsalva aneurysm (SOVA), a congenital or acquired cardiac defect that is present in roughly 0.09% of the general population, often presents as an incidental finding during cardiac imaging. Although an echocardiogram is the standard imaging technique for such findings, cardiac computed tomography angiography (CCTA) has been increasingly utilized. If SOVA is diagnosed, CCTA is also a useful test for patients who are at low to intermediate risk for coronary artery disease (CAD) prior to surgical repair. CCTA can accurately rule out CAD, obviating the need for invasive angiography in most cases, which may be more risky in SOVA patients because their coronaries may be more difficult to engage and their aortic root may be more prone to injury. Although surgery has previously been the treatment of choice, transcatheter techniques have added to the spectrum of nonsurgical alternatives for repair. We report here 4 incidental SOVA cases and review the current literature.
Incidence of secondary malignancies among patients with Waldenström macroglobulinemia: An analysis of the SEER database
Authors: Castillo Jorge J. , Olszewski Adam J. , Hunter Zachary R. , Kanan Sandra , Meid Kirsten , Treon Steven P. 
Published: March 2015

BACKGROUNDWaldenström macroglobulinemia (WM) is an indolent malignancy that predominantly affects older individuals who are at risk for secondary malignancies (SMs). The objective of this study was to characterize the incidence of SMs after a diagnosis of WM with the Surveillance, Epidemiology, and End Results (SEER) database.METHODSWith SEER‐13 data (1992‐2011), standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated for the rates of solid and hematologic SMs in WM patients versus the general population. The analysis was stratified by age, sex, race, year of diagnosis, and latency from the WM diagnosis.RESULTSAmong 4676 patients with WM, 681 SMs were recorded. The overall SIR was 1.49 (95% CI, 1.38‐1.61), and the median time to an SM was 3.7 years. The cumulative incidence of SMs was 10% at 5 years and 16% at 10 years. The risk was significantly increased for cancers of the lungs, urinary tract, and thyroid; melanoma; aggressive lymphoma; and acute leukemia. The SIR for SMs in patients with WM was increased, regardless of age, sex, race, or year of diagnosis.CONCLUSIONSPatients with WM had a 49% higher risk of SMs than the general population. The selectively increased risk for hematologic SMs and certain solid SMs may be associated with transformation, therapy, and immune dysregulation. Cancer 2015;121:2230–2236. © 2015 American Cancer Society.
Assemblies of Copper Ferrite and Palladium Nanoparticles on Silica Microparticles as a Magnetically Recoverable Catalyst for Sonogashira Reaction under Mild Conditions
Authors: Gholinejad Mohammad , Ahmadi Jahantab 
Published: March 2015

AbstractCopper ferrite and palladium nanoparticles assembled on silica microparticles are prepared successfully and characterized by scanning electron microscopy, transmission electron microscopy, electron‐dispersive X‐ray analysis, X‐ray diffraction, thermogravimetric analysis, atomic absorption spectroscopy, and infrared studies. The catalyst is applied effectively for the Sonogashira coupling reaction of aryl iodides and bromides under heterogeneous and phosphine‐free reaction conditions. The reactions proceed at 50 °C with a low loading of palladium catalyst. The magnetically recoverable catalyst is recycled successfully for five consecutive runs with very small drops in catalytic activity.
‘Of the group’ and ‘for the group’: How followership is shaped by leaders' prototypicality and group identification
Authors: Steffens Niklas K. , Schuh Sebastian C. , Haslam S. Alexander , Pérez Antonia , van Dick Rolf 
Published: March 2015

AbstractPrevious research has focused on the importance of leaders being seen to be of the group (i.e. to be prototypical of a group) but less on the impact of leaders' own degree of identification with the group. Also, little is known about the combined impact of leader prototypicality and leader identification on followers' responses. This paper reports two studies that address these lacunae. Study 1 shows experimentally that perceived leader identification and prototypicality interact to determine followers' personal identification with leaders and their perceptions of leader charisma. Findings indicate that high identification can compensate for low prototypicality such that high‐identified leaders are able to inspire followership when leaders are low prototypical. Study 2 replicates these findings in the field by examining followers' responses to workgroup leaders. In addition, results demonstrate that the aforementioned responses are more pronounced for highly identified followers. The present research extends social identity theorizing by demonstrating that leaders' inability to inspire followership derives as much from their failure to project a sense of ‘we’ and ‘us’ as part of their self‐concept as from a failure to exemplify group‐typical attributes. Copyright © 2015 John Wiley & Sons, Ltd.
Modulation of hippocampal theta and hippocampal‐prefrontal cortex function by a schizophrenia risk gene
Authors: Cousijn Helena , Tunbridge Elizabeth M. , Rolinski Michal , Wallis George , Colclough Giles L. , Woolrich Mark W. , Nobre Anna C. , Harrison Paul J. 
Published: March 2015

AbstractHippocampal theta‐band oscillations are thought to facilitate the co‐ordination of brain activity across distributed networks, including between the hippocampus and prefrontal cortex (PFC). Impairments in hippocampus‐PFC functional connectivity are implicated in schizophrenia and are associated with a polymorphism within the ZNF804A gene that shows a genome‐wide significant association with schizophrenia. However, the mechanisms by which ZNF804A affects hippocampus‐PFC connectivity are unknown. We used a multimodal imaging approach to investigate the impact of the ZNF804A polymorphism on hippocampal theta and hippocampal network coactivity. Healthy volunteers homozygous for the ZNF804A rs1344706 (A[risk]/C[nonrisk]) polymorphism were imaged at rest using both magnetoencephalography (MEG) and functional magnetic resonance imaging (fMRI). A dual‐regression approach was used to investigate coactivations between the hippocampal network and other brain regions for both modalities, focusing on the theta band in the case of MEG. We found a significant decrease in intrahippocampal theta (using MEG) and greater coactivation of the superior frontal gyrus with the hippocampal network (using fMRI) in risk versus nonrisk homozygotes. Furthermore, these measures showed a significant negative correlation. Our demonstration of an inverse relationship between hippocampal theta and hippocampus‐PFC coactivation supports a role for hippocampal theta in coordinating hippocampal‐prefrontal activity. The ZNF804A‐related differences that we find in hippocampus‐PFC coactivation are consistent with previously reported associations with functional connectivity and with these changes lying downstream of altered hippocampal theta. Changes in hippocampal‐PFC co‐ordination, driven by differences in oscillatory activity, may be one mechanism by which ZNF804A impacts on brain function and risk for psychosis. Hum Brain Mapp 36:2387–2395, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
Ipsilateral hippocampal atrophy is associated with long‐term memory dysfunction after ischemic stroke in young adults
Authors: Schaapsmeerders Pauline , van Uden Inge W.M. , Tuladhar Anil M. , Maaijwee Noortje A.M. , van Dijk Ewoud J. , Rutten‐Jacobs Loes C.A. , Arntz Renate M. , Schoonderwaldt Hennie C. , Dorresteijn Lucille D.A. , de Leeuw Frank‐Erik , Kessels Roy P.C. 
Published: March 2015

AbstractMemory impairment after stroke in young adults is poorly understood. In elderly stroke survivors memory impairments and the concomitant loss of hippocampal volume are usually explained by coexisting neurodegenerative disease (e.g., amyloid pathology) in interaction with stroke. However, neurodegenerative disease, such as amyloid pathology, is generally absent at young age. Accumulating evidence suggests that infarction itself may cause secondary neurodegeneration in remote areas. Therefore, we investigated the relation between long‐term memory performance and hippocampal volume in young patients with first‐ever ischemic stroke. We studied all consecutive first‐ever ischemic stroke patients, aged 18–50 years, admitted to our academic hospital center between 1980 and 2010. Episodic memory of 173 patients was assessed using the Rey Auditory Verbal Learning Test and the Rey Complex Figure and compared with 87 stroke‐free controls. Hippocampal volume was determined using FSL‐FIRST, with manual correction. On average 10 years after stroke, patients had smaller ipsilateral hippocampal volumes compared with controls after left‐hemispheric stroke (5.4%) and right‐hemispheric stroke (7.7%), with most apparent memory dysfunctioning after left‐hemispheric stroke. A larger hemispheric stroke was associated with a smaller ipsilateral hippocampal volume (b=−0.003, P<0.0001). Longer follow‐up duration was associated with smaller ipsilateral hippocampal volume after left‐hemispheric stroke (b=−0.028 ml, P=0.002) and right‐hemispheric stroke (b=−0.015 ml, P=0.03). Our results suggest that infarction is associated with remote injury to the hippocampus, which may lower or expedite the threshold for cognitive impairment or even dementia later in life. Hum Brain Mapp 36:2432–2442, 2015. © 2015 Wiley Periodicals, Inc.
Functional Significance of Nuclear α Spectrin
Authors: Lambert Muriel W. 
Published: March 2015

ABSTRACTNonerythroid alpha spectrin (αIISp) interacts in the nucleus with an array of different proteins indicating its involvement in a number of diverse functions. However, the significance of these interactions and their functional importance has been a relatively unexplored area. The best documented role of nuclear αIISp is in DNA repair where it is critical for repair of DNA interstrand cross‐links (ICLs), acting as a scaffold recruiting proteins to sites of damage in genomic and telomeric DNA. A deficiency in αIISp can importantly impact DNA ICL repair as is seen in cells from patients with the genetic disorder, Fanconi anemia (FA), where loss of αIISp leads to not only defects in repair of both genomic and telomeric DNA but also to telomere dysfunction and chromosome instability. This previously unexplored link between αIISp and telomere function is important in developing an understanding of maintenance of genomic stability after ICL damage. In FA cells, these defects in chromosome instability after ICL damage can be corrected when levels of αIISp are returned to normal by knocking down μ‐calpain, a protease which cleaves αIISp. These studies suggest a new direction for correcting a number of the phenotypic defects in FA and could serve as a basis for therapeutic intervention. More in depth, examination of the interactions of αIISp with other proteins in the nucleus is of major importance in development of insights into the interacting key elements involved in the diverse processes occurring in the nucleus and the consequences loss of αIISp has on them. J. Cell. Biochem. 116: 1816–1830, 2015. © 2015 Wiley Periodicals, Inc.
Systems Chemo‐Biology and Transcriptomic Meta‐Analysis Reveal the Molecular Roles of Bioactive Lipids in Cardiomyocyte Differentiation
Authors: de Faria Poloni Joice , Bonatto Diego 
Published: March 2015

ABSTRACTLipids, which are essential constituents of biological membranes, play structural and functional roles in the cell. In recent years, certain lipids have been identified as regulatory signaling molecules and have been termed “bioactive lipids”. Subsequently, the importance of bioactive lipids in stem cell differentiation and cardiogenesis has gained increasing recognition. Therefore, the aim of this study was to identify the biological processes underlying murine cardiac differentiation and the mechanisms by which bioactive lipids affect these processes. For this purpose, a transcriptomic meta‐analysis of microarray and RNA‐seq data from murine stem cells undergoing cardiogenic differentiation was performed. The differentially expressed genes identified via this meta‐analysis, as well as bioactive lipids, were evaluated using systems chemo‐biology tools. These data indicated that bioactive lipids are associated with the regulation of cell motility, cell adhesion, cytoskeletal rearrangement, and gene expression. Moreover, bioactive lipids integrate the signaling pathways involved in cell migration, the secretion and remodeling of extracellular matrix components, and the establishment of the cardiac phenotype. In conclusion, this study provides new insights into the contribution of bioactive lipids to the induction of cellular responses to various stimuli, which may originate from the extracellular environment and morphogens, and the manner in which this contribution directly affects murine heart morphogenesis. J. Cell. Biochem. 116: 2018–2031, 2015. © 2015 Wiley Periodicals, Inc.
Therapeutic role of curcumin in oxidative DNA damage caused by formaldehyde
Authors: Ciftci Gulay , Aksoy Abdurrahman , cenesiz Sena , sogut Mehtap unlu , Yarim Gul Fatma , Nisbet Cevat , Guvenc Dilek , Ertekin Ali 
Published: March 2015

ABSTRACTPurposeFormaldehyde is a common environmental contaminant that causes oxidative DNA damage in cells by increasing the production of reactive oxygen species. The aim of this study was to investigate the amount of 8‐hydroxy‐deoxyguanosine (8‐OhdG), tumor protein 53(TP53), beta‐amyloid[Aß(1‐42), Aß (1‐40)], total antioxidant capacity (TAC) and malondialdehyde (MDA) and the therapeutic role of curcumin in rat cells with oxidative DNA damage caused by formaldehyde. Method: The control group was given physiological saline for 15 days (ip) and the second group was given 37% formaldehyde (ip) at a dose of 9 mg/kg group every other day. The third group was given 9 mg/kg formaldehyde (ip) every other day and treated therapeutically with 100 mg/kg curcumin every day by gavage. At the end of the trial period, urine, blood, and brain tissue was collected from the rats. Results: The levels of MDA in sera were increased and the TAC, TP53, and Aß (1−40) levels were reduced in the formaldehyde‐treated group with respect to the control group (p<0.005). After treatment with curcumin, the levels of sera MDA were significantly reduced, the TAC, TP53, and Aß (1‐40) levels were significantly increased (P < 0.05). The levels of whole brain Aß (1‐42) and 8‐OhdG were increased in the formaldehyde‐treated group and reduced after treatment with curcumin (P < 0.05). Urinary 8‐OhdG excretion increased in the formaldehyde‐treated group (P < 0.05) and decreased after treatment with curcumin (P > 0.05).ConclusionsIn conclusion, the oxidative stress caused by formaldehyde exposure was reduced with the application of curcumin. Microsc. Res. Tech. 78:391–395, 2015. © 2015 Wiley Periodicals, Inc.
Study of the sensitivity and resonant frequency of the torsional modes of an AFM cantilever with a sidewall probe based on a nonlocal elasticity theory
Authors: Abbasi Mohammad , Karami Mohammadi Ardeshir 
Published: March 2015

ABSTRACTA relationship based on a nonlocal elasticity theory is developed to investigate the torsional sensitivity and resonant frequency of an atomic force microscope (AFM) with assembled cantilever probe (ACP). This ACP comprises a horizontal cantilever and a vertical extension, and a tip located at the free end of the extension, which makes the AFM capable of topography at sidewalls of microstructures. First, the governing differential equations of motion and boundary conditions for dynamic analysis are obtained by a combination of the basic equations of nonlocal elasticity theory and Hamilton's principle. Afterward, a closed‐form expression for the sensitivity of vibration modes has been obtained using the relationship between the resonant frequency and contact stiffness of cantilever and sample. These analysis accounts for a better representation of the torsional behavior of an AFM with sidewall probe where the small‐scale effect are significant. The results of the proposed model are compared with those of classical beam theory. The results show that the sensitivities and resonant frequencies of ACP predicted by the nonlocal elasticity theory are smaller than those obtained by the classical beam theory. Microsc. Res. Tech. 78:408–415, 2015. © 2015 Wiley Periodicals, Inc.
Development and implementation of healthcare waste management policy at Civil Service Hospital, Nepal
Authors: Sapkota Binaya , Gupta Gopal Kumar , Mainali Dhiraj , Shrestha Nirmal 
Published: March 2015

AbstractOver the last 5 years, the Civil Service Hospital (Nepal) has dealt with various serious health hazards including infectious diseases and other important risks. A management committee was appointed to develop a healthcare waste management policy in 2013. The policy deals with the management of safety issues associated with occupational hazards, as well as raising public awareness of the importance of proper waste management. Safe management of healthcare waste enhances patient safety and promotes occupational safety. This policy was categorised into three chapters: preliminary discussion, organisational and managerial aspects and occupational health and safety. The policy was implemented in several phases. During the first phase, medicine, orthopedics, gynecology, obstetrics and paediatric services were targeted, while the second phase included the surgical, post‐operative and haematology wards, the high care unit and emergency and laboratory departments. The third phase involved the pharmacy, out‐patient department and hospital administration, while the fourth phase eventually included the whole hospital. Development of this policy was guided by Government of Nepal Solid Waste Management Act 2011 and the World Health Organisation Guidelines.
Improving the transition of elderly patients with multiple comorbidities into the community: impact of a pharmacist in a General Medicine outpatient follow‐up clinic
Authors: Tong Erica , Choo Shin , Ooi Sheue‐Ching , Newnham Harvey 
Published: March 2015

AbstractAimTo investigate the impact of extending the traditional roles of pharmacists from that of providing a service to inpatients under the General Medical Unit in the acute hospital setting, to the enhancement of continuity of care and reduction in medication misadventure by implementing clinical pharmacy services in the outpatient follow‐up clinic.MethodA prospective pilot study was conducted in the General Medical Unit post‐discharge follow‐up clinic between March 2012 and February 2014. Each patient enrolled in the study was reviewed by a pharmacist through a scheduled 20 min consultation after their appointment with the medical doctor. Patient's demographic data, number of days from discharge to clinic review and number of regular medications were collected. Drug‐related problems (DRPs) identified by the pharmacist were recorded. Any discrepancies from the discharge medication plan identified by the pharmacist were also recorded, in addition to compliance issues, initiation of dose‐administration aids and referrals to the outreach pharmacy service.ResultsEighty‐seven patients were enrolled (average age: 73 years) with an average time between discharge and clinic review of 25 days. The most frequent intervention made by the pharmacist was therapeutic drug monitoring (74%) followed by counselling on new or changed medications (49%). The pharmacist identified a number of patients who had continued taking medications that were ceased during their admission (15%) and patients who were not taking medications which had been initiated during hospitalisation (15%). Ten patients (11%) were taking the wrong dose of at least one medication. At least one DRP was identified in 77 (89%) patients, and discrepancies between the discharge medication plan and what the patient was taking at the time of the clinic visit were identified in 33 patients (38%).ConclusionMedication discrepancies often occur at transitions of care. Our data highlight the potential role of a pharmacist in this setting and the importance that the medication management plan put in place at the time of discharge should be communicated to the appropriate healthcare practitioners and the patient.
PRO‐OSTEO Extend I study (improving osteoporosis management in the acute and rehabilitation settings): multicentre audit
Authors: Banakh Iouri , Chao Sarah 
Published: March 2015

AbstractBackgroundOsteoporosis contributes to a large number of admissions to hospitals after minimal‐trauma fractures but is poorly recognised as an underlying cause of admissions and may be inadequately managed following hospitalisation.AimThe aim of this study was to examine osteoporosis management across Peninsula Health, assessing the effect of the introduction of a standard form to guide osteoporosis management after minimal‐trauma fractures.MethodThis was a retrospective cohort study measuring rates of osteoporosis assessment and treatment for patients admitted with minimal‐trauma fractures. Two periods were compared (in 2012 and 2013), before and after the introduction of an osteoporosis management form that allowed a pharmacist‐driven approach to management. The study end points were the extents of use of the osteoporosis form and the rates of osteoporosis assessment and treatment.ResultsOsteoporosis assessment and treatment rates varied widely across Peninsula Health, with acute wards such as the emergency departments providing no assessment or treatment (before and after the intervention). The uptake of the osteoporosis management form was negligible in the post‐intervention period. The overall 2‐year mortality rate was 7.4% following any fracture within 2 years of admission, and up to 33% following a hip or neck of femur fracture at some sites.ConclusionOsteoporosis management remained inadequate in the hospital settings despite intervention. Strategies such as ongoing prescriber education and employment of a local change champion specialised in osteoporosis management with support from all departments may be needed to achieve the aim of lowering the morbidity and mortality associated with this disease.