bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intra‐ and interindividual variability in fasted gastric content volume
Authors: Roelofs Julia J. M. , Camps Guido , Leenders Louise M. , Marciani Luca , Spiller Robin C. , Van Eijnatten Elise J. M. , Alyami Jaber , Deng Ruoxuan , Freitas Daniela , Grimm Michael , Karhunen Leila J. , Krishnasamy Shanthi , Le Feunteun Steven , Lobo Dileep N. , Mackie Alan R. , Mayar Morwarid , Weitschies Werner , Smeets Paul A. M. 
Published: August 2024

AbstractBackgroundGastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra‐ and interindividual variation in fasted gastric content volume (FGCV) and to determine the association with age, sex, and body size characteristics.MethodsData from 24 MRI studies measuring FGCV in healthy, mostly young individuals after an overnight fast were pooled. The analysis included 366 participants who had up to 6 repeated measurements, with a total of 870 measurements. Linear mixed model analysis was performed to calculate intra‐ and interindividual variability and to assess the effects of age, sex, weight, height, weight*height as a proxy for body size, and body mass index (BMI).ResultsFGCV ranged from 0 to 156 mL, with a mean (± SD) value of 33 ± 25 mL. The overall coefficient of variation within the study population was 75.6%, interindividual SD was 15 mL, and the intraindividual SD was 19 mL. Age, weight, height, weight*height, and BMI had no effect on FGCV. Women had lower volumes compared to men (MD: −6 mL), when corrected for the aforementioned factors.ConclusionFGCV is highly variable, with higher intraindividual compared to interindividual variability, indicating that FGCV is subject to day‐to‐day and within‐day variation and is not a stable personal characteristic. This highlights the importance of considering FGCV when studying digestion and drug dissolution. Exact implications remain to be studied.
Vessel density, macula thickness and foveal avascular zone measurements in young African adults with moderate myopia: A pilot study
Authors: Munsamy Alvin J. , Monthati Lehlomela , Minenhle Mlambo , Zwelakhe Mngomezulu , Nokubongwa Ndlovu , Mthobisi Radebe 
Published: August 2024

AbstractPurposeThe aim of this study was to investigate the association between macula thickness and vessel density in African myopic and emmetropic eyes through the use of Spectral Domain Optical Coherence Tomography (OCT).MethodsThe study population comprised African adults aged 18–35 years old. The study was conducted at a University eye clinic located in Durban, South Africa. Purposive sampling was utilised to obtain 59 participants of whom 24 were myopes and 35 were emmetropes. Vessel density (VD), foveal avascular zone (FAZ) and retinal thickness (RT) were obtained using the Heidelberg Spectralis OCT with angiography. Thereafter, a multivariate linear regression was used to investigate associations between the spherical equivalent myopic refractive error and VD, FAZ and RT for the myopic group only.ResultsMyopic participants had a mean spherical equivalent (MSE) and standard deviation (SD) of −4.79 D (1.27) while the emmetropic group had an MSE (SD) of −0.32 D (0.46). Both superficial and deep VD were significantly decreased at the central fovea (radius (r) = 0.4 mm), peri‐foveal (r = 1.10–1.45 mm) and para‐foveal (r = 0.75–1.10 mm) sectors in myopes when compared with emmetropes. Myopes showed a significant reduction in RT in the inner retinal layer across the inferior and temporal zones of the peri‐foveal region as well as the inferior and temporal zones of the para‐foveal region when compared with emmetropes. A significantly smaller FAZ was found at both the superficial and deep vascular plexuses (p < 0.001). In African myopes, significant associations were not found between MSE and VD or FAZ and macula retinal thickness.ConclusionRetinal vascular and thickness reduction may occur in young African adults with moderate myopia. A broad‐based study targeting VD and IRT in African myopes is proposed to confirm preclinical myopic macula disruptions in adults of African ethnicity. OCT angiography should be considered when monitoring progressive myopia.
Ilizarov Distraction for Congenital Pseudoarthrosis of the Tibia in Adults
Authors: Li Yaxing , Li Jia , Gan Tingjiang , Geng Qirui , Ma Xikun , Yin Shijiu , Wu Ye , Fang Xiang , Xie Huiqi , Zhang Hui 
Published: August 2024

ObjectiveThe clinical evidence on the management for congenital pseudoarthrosis of the tibia (CPT) in adults is limited. The aim of this study is to assess the functional and radiological outcomes of Ilizarov distraction for treating CPT in adults.MethodsA retrospective analysis was conducted. Between 2013 and 2022, an Ilizarov distraction technique was performed on 14 adults (14 limbs) with CPT in our limb deformity center. There were seven females and seven males with a mean age of 33.7 (range, 18 ~ 53) years. The diagnosis of NF‐1 was confirmed in seven (50.0%) patients. Eight patients had a history of previous surgical failure. The pseudoarthrosis occurred in the middle and lower tibia in all limbs (six left and eight right). The CPT was classified by Crawford classification and Paley classification. The surgical procedures, external fixation time (EFT), and all outcomes and complications were recorded. The Kolmogorov–Smirnov test was performed to test the normality of the data. The American Orthopedic Foot and Ankle Society (AOFAS) ankle‐hindfoot score at the preoperative and final follow‐up was compared by using the Wilcoxon's signed‐rank test. The limb‐length discrepancy (LLD) and a self‐made exercise capacity score at the preoperative and final follow‐up were compared by using the student's t‐test. The clinical and radiological outcomes were assessed by the Inan scale.ResultsThe mean EFT of Ilizarov fixator was 19.5 months (range, 7.3 ~ 39.1). At a median follow‐up of 26.8 months (IQR, 20.2 ~ 34.3), bone union of the pseudarthrosis and consolidation of the distraction zone were achieved in all patients. The mean LLD was decreased from 11.3 cm (range, 3.4 ~ 17.3) preoperatively to 1.1 cm (range, 0.3 ~ 3.7) (p < 0.05). The mean or median AOFAS ankle‐hindfoot score was improved from 53.5 (IQR, 26.5 ~ 60.5) preoperatively to 63.9 (range, 53 to 73) at final follow‐up (p < 0.05). The mean score for exercise capacity were improved from 4.9 (range, 1 to 8) preoperatively to 9.6 (range, 7 ~ 12) at final follow‐up (p < 0.05). According to the criteria described by Inan et al., the clinical results were classified as good in 10 and fair in 4, while the radiological results were classified as excellent in three, good in 8, and fair in 2. The success rate was 92.9%, as refracture was defined as treatment failure and occurred in one patient.ConclusionIlizarov distraction provided a suitable treatment option for the CPT in adults, as it could achieve a high rate of bone union, a good correction of secondary deformity, a low risk of refracture, and consequently restore a relatively functional limb.
Focal Dome Osteotomy Combined with Ilizarov Technique for Treating Femoral Multiplanar Deformity
Authors: Li Yaxing , Li Jia , Gan Tingjiang , Gong Heng , Ma Xikun , Yin Shijiu , Qin Boquan , Wu Shizhou , Xie Huiqi , Zhang Hui 
Published: August 2024

ObjectiveThe management of femoral multiplanar deformity remains a great challenge for orthopaedic surgeons. The focal dome osteotomy (FDO) combined with Ilizarov technique is a theoretically ideal method for treating femoral multiplanar deformity, but the clinical evidence is limited. The aim of this study is to assess the clinical and radiological outcomes of this combined strategy for correcting femoral multiplanar deformities.MethodsA retrospective analysis was conducted to analyze 20 patients (29 limbs) with femoral multiplanar deformities treated by FDO combined with Ilizarov external fixation in our limb deformity center between 2017 and 2022. Preoperative and postoperative radiographical parameters were measured, including lateral proximal femoral angle (LPFA), mechanical lateral distal femoral angle (mLDFA), middle diaphysis angle (MDA), anatomic posterior distal femoral angle (aPDFA), mechanical axis deviation (MAD), and limb length discrepancy (LLD). Clinical assessments included a self‐made questionnaire for exercise capacity score (ECS), visual analog scale (VAS), and the 36‐Item Short‐Form Health Survey (SF‐36) score.ResultsThere were eight males and 12 females, with a mean age of 32.8 years (14–61 years). All patients completed follow‐up with a mean follow‐up duration of 41.5 (27–81) months. The mean EFT was 8.9 (1.4–20.2) months. At final follow‐up, significantly improvement was noted regarding mean LLD (from 1.8 to 0.4 cm, p < 0.05), MDA (from 31.8° to 10.4°, p < 0.05), aPDFA (from 97.6° to 91.8°, p < 0.05), MAD (from 22.4 to 5.3 mm, p < 0.05), CORA on the true deformity plane (from 32.4° to 6.8°, p < 0.05). The mean VAS was decreased from 4.03 (2.0–6.0) preoperatively to 1.38 (0–3.0) at final follow‐up (p < 0.05). The mean score of each item of SF‐36 was significantly improved at final follow‐up (p < 0.05). The mean ECS was improved from 8.2 (5–12) preoperatively to 11.4 (8–13) at final follow‐up (p < 0.05). During the follow‐up, one patient underwent pin exchange. One patient underwent internal fixation to replace the Ilizarov fixation 1.4 months after the first surgery. Residual LLD (>0.5 cm) was noted in four patients but without significant symptoms. No serious complications occurred.ConclusionsThe strategy of FDO combined with Ilizarov fixation could provide powerful ability and good flexibility for correcting femoral multiplanar deformities without significant complications.
The Gradual Correction of Rigid Pes Cavus Using Midfoot Osteotomy Combined with Ilizarov Methods
Authors: Li Yaxing , Qin Boquan , Li Jia , Yin Shijiu , Ren Yi , Wu Ye , Fang Xiang , Xie Huiqi , Zhang Hui 
Published: August 2024

ObjectiveMidfoot osteotomy combined with Ilizarov methods of correction is a rarely reported treatment that is particularly well‐suited for severe rigid pes cavus. The study aimed to assess the radiological and clinical results of patients who had been treated for rigid pes cavus using this method.MethodsThe study retrospectively analyzed the clinical and radiological data of 15 pes cavus in 12 patients who were corrected by midfoot osteotomy with Ilizarov external frame in our department from March 2020 to September 2022. Radiologic outcomes were measured using the Meary angle (MA), talus‐first metatarsal angle (TM1A), calcaneal varus angle (CVA) and foot length with weight‐bearing radiographs. Functional assessments were evaluated in terms of pain, function, and quality of life by using the visual analogue scale (VAS), the American Orthopedic Foot and Ankle Society hindfoot scale score (AOFAS), and 36‐item Short Form Health Survey (SF‐36). Additionally, the postoperative satisfaction of patients was investigated by a questionnaire. The clinical and radiological results were evaluated by a paired t‐test.ResultsAll patients received plantigrade feet and pain relief. The mean follow‐up was 33.1 ± 5.0 months (range from 25 to 41 months). The etiology included poliomyelitis (4), idiopathic (3), trauma (2), spina bifida (2) and tethered cord syndrome (1). The duration of gradual correction was 30.4 ± 10.6 days, and the external fixation time was 116.3 ± 33.3 days. The bony union rate was 100%. The VAS, AOFAS, and SF‐36 scores significantly improved (p < 0.05). The MA, TM1A, and CVA were close to or reached the normal range postoperative (p < 0.01). The length of each foot was well preserved, which was increased more than 0.8 cm than preoperative. No major complications were reported except two cases of mildly hindfoot varus deformity. The results of the questionnaire showed that patients' satisfaction was 92% (11/12).ConclusionMidfoot osteotomy combined with Ilizarov external frame proved to be a reasonable procedure with satisfying mid‐term results for the gradual correction of rigid pes cavus.
Investigating the causal relationship between major depressive disorder and benign prostatic hyperplasia: a bidirectional Mendelian randomisation study
Authors: Zheng Guanghao , Xiao Shuaiyun , Cheng Yu , Huang Jianbiao , Luo Chengwei , Peng Lifen , Zeng Tao 
Published: August 2024

AbstractBackgroundEvidence from various cohort studies indicate a potential association between depressive disorder and benign prostatic hyperplasia (BPH), yet findings are inconsistent. This study employs bidirectional two‐sample Mendelian randomisation (MR) analysis to explore the causal relationship between BPH and major depressive disorder (MDD).MethodsGenetic variants strongly associated with MDD were extracted as instrumental variables conducted by the Psychiatric Genomics Consortium (PGC). Two sets of genetic variants associated with BPH were extracted from the recent FinnGen and Medical Research Council‐Integrative Epidemiology Unit Consortium of BPH as the discovery and replication stages, respectively. Bidirectional MR analysis employed methods such as inverse variance weighted, MR‐Egger, weighted median, maximum likelihood, and weighted mode. The inverse variance weighted method was primarily used to evaluate the causal relationship.ResultsMR analysis in both the discovery and replication stages showed a significant causal relationship between MDD and the risk of BPH (discovery stages, odds ratio (OR) = 1.1146, 95% CI 1.0058–1.2353, P = 0.03852; replication stage, OR: 1.0042, 95% CI 1.0019–1.0065, P = 0.0004). No causal relationship was found between BPH and MDD risk in the reverse MR analysis.ConclusionsOur findings highlight a significant association between MDD and an increased risk of BPH development. Further investigation is needed to elucidate the underlying mechanisms linking depression and BPH.
Arsenical keratosis in China: A case report and review of the literature
Authors: Tao Rong , Wang Ruojun 
Published: August 2024

AbstractBackgroundArsenical keratosis is a precancerous dermatosis which could be induced by long‐term exposure to arsenic poisoning. Arsenic is often added to traditional Chinese medicine in a non‐compliant manner to increase the effectiveness of psoriasis treatment, which is often the main cause of arsenic poisoning in Chinese patients with psoriasis.ObjectivesWe performed a systemic review of arsenic keratosis during the past 32 years to better understand the sources, treatment, and prognosis of arsenic keratosis in China.MethodsWe searched Medline/PubMed, Embase, CNKI, and Wanfang databases for research studies published between 1992 and 2024. A total of 64 papers with 78 individual Chinese of arsenical keratosis were included in this analysis.ResultsOf the patients included in the analysis, 92.21% of arsenic poisoning was due to iatrogenic factors: Chinese traditional medicine. Seventy‐six patients (98.70%) had skin manifestation of hyperkeratotic papules and plaques, 68 patients (88.31%) had hyperpigmentation, 43 cases (55.84%) had hypopigmentation, and only 4 had a clear indication of Mees' lines in nails. A total of 52.63% of patients presented with tumors, including squamous cell carcinoma, Bowen's disease, and basal cell carcinoma. For patients with tumors, 20 opted for surgery, 6 for radiotherapy, and 3 for PDT. All patients with only cutaneous tumors are currently well‐controlled. Death occurred in one patient with metastatic squamous cell carcinoma. Keratinizing papules improved significantly in 70.59% of patients treated with Acitretin Capsules.ConclusionsIn this study, arsenic sources in Chinese patients were mainly from traditional Chinese medicine, and there were no reports of exposure to water sources or occupational sources in the past 32 years. Most of the patients showed keratinizing papules and pigmentation, and more than 1/2 of the patients showed skin tumors, mainly squamous cell carcinoma. The treatments of tumors are mainly surgical treatment, PDT and radiotherapy can also be selected. The improvement in keratinizing rash was greater than 70% with acitretin capsules. Patients with this disease should be regularly followed up for early detection and timely treatment of potential malignant tumors.
CO2‐Rich Xenoliths at Mt. Vulture Volcano (Southern Italy): New Constraints on the Volcano Plumbing System
Authors: Carnevale Gabriele , Caracausi Antonio , Coltorti Massimo , Faccini Barbara , Marras Giulia , Paternoster Michele , Rotolo Silvio G. , Stagno Vincenzo , Zanon Vittorio , Zummo Filippo 
Published: August 2024

ABSTRACTThis study provides new mineral chemistry data together with micro‐thermometric measurements on fluid inclusions hosted in ultramafic xenoliths (lherzolite, wehrlite, and dunite) brought to the surface by the last Mt. Vulture volcano activity (140 ka; southern Italy), and fed by melilitite‐carbonatite magmas. Petrographic evidence and mineralogical compositions of Mt. Vulture xenoliths are consistent with an origin in the upper mantle. Fluid inclusions in rock‐forming minerals of lherzolite and wehrlite xenoliths are CO2‐dominated. The equilibrium temperature calculated by geothermometric estimates ranges from 1039 C (±36°C) to 1142°C (±15°C), and entrapment pressures of fluid inclusions with post‐trapping re‐equilibration correspond to the local crust–mantle boundary (32 km depth), and to a shallow reservoir located at 12–14 km depth. These results contribute to constrain the origin of these xenoliths and the depth of storage of magmas erupted from Mt. Vulture, where carbonatite‐like metasomatism and mantle‐derived CO2 degassing occur.
Acceptability of sexual history questions in a gender‐neutral risk assessment for blood donation
Authors: Mowat Yasmin , Haire Bridget , Masser Barbara , Hoad Veronica , Heywood Anita , Thorpe Rachel , McManus Hamish , Kaldor John , McGregor Skye 
Published: August 2024

AbstractBackgroundCurrently in Australia, men are deferred from donating blood if they have had sex with another man within the past 3  months. However, a proposed gender‐neutral assessment (GNA) process will ask all donors questions about sex with new or multiple recent partners, with deferral based on responses to a question about anal sex. Understanding the acceptability of such questions among existing and potential blood donors is paramount for successful implementation of GNA.Study Design and MethodsWe used data from a nationally representative survey to estimate the levels of comfort with the proposed GNA questions among the Australian population and subgroups, defined by self‐reported ethnicity and religion. Respondents were aged over 18 and living in Australia. Results were weighted to represent the population.ResultsMost of the 5178 respondents described themselves as comfortable with answering questions about new partners (73.1%) or anal sex (64.0%) to donate blood. However, 2.2% and 4.5% indicated that questions about new sex partners and anal sex, respectively, would stop them from donating, and 4.4% and 7.7% respectively, said they were “completely uncomfortable.” By religion, the least comfortable were Muslim or Eastern Orthodox respondents, and by country of birth, the least comfortable were those born in the Middle East, followed by those born in Southern Europe and Asia.DiscussionGNA appears to be broadly acceptable in the Australian context, but our findings suggest that key GNA questions are less acceptable in some population subgroups, indicating a need for targeted campaigns that consider cultural sensitivities.
Ketone monoester attenuates declines in cognitive performance and oxygen saturation during acute severe hypoxic exposure under resting conditions
Authors: McClure Tyler S. , Phillips Jeffrey , Koutnik Andrew P. , Coleman Kody , Chappe Ed , Cutter Gary R. , Egan Brendan , Norell Todd , Stubbs Brianna J. , Bamman Marcas M. , Kernagis Dawn 
Published: August 2024

AbstractExogenous ketone supplements are a potential augmentation strategy for cognitive resilience during acute hypoxic exposure due to their capacity to attenuate the decline in oxygen (O2) availability, and by providing an alternative substrate for cerebral metabolism. Utilizing a single‐blind randomized crossover design, 16 male military personnel (age, 25.3 ± 2.4 year, body mass, 86.2 ± 9.3 kg) performed tests of cognitive performance at rest in three environments: room air (baseline), normoxia (20 min; 0 m; 20.9% O2) and hypoxia (20 min; 6096 m, 9.7% O2) using a reduced O2 breathing device (ROBD). (R)‐3‐Hydroxybutyl (R)‐3‐hydroxybutyrate (R‐BD R‐βHB) ketone monoester (KME; 650 mg/kg, split dose given at 30 min prior to each exposure) or taste‐matched placebo (PLA) was ingested prior to normoxia and hypoxic exposure. Blood R‐βHB and glucose concentrations, cognitive performance and O2 saturation () were collected throughout. KME ingestion increased blood R‐βHB concentration, which was rapid and sustained (>4 mM 30 min post; P < 0.001) and accompanied by lower blood glucose concentration (∼20 mg/dL; P < 0.01) compared to PLA. Declines in cognitive performance during hypoxic exposure, assessed as cognitive efficiency during a Defense Automated Neurobehavioral Assessment (DANA) code substitution task, were attenuated with KME leading to 6.8 (95% CL: 1.0, 12.6) more correct responses per minute compared to PLA (P = 0.018). The decline in during hypoxic exposure was attenuated (6.40% ; 95% CL: 0.04, 12.75; P = 0.049) in KME compared to PLA (KME, 76.8 ± 6.4% ; PLA, 70.4 ± 7.4% ). Acute ingestion of KME attenuated the decline in cognitive performance during acute severe hypoxic exposure, which coincided with attenuation of declines in O2 saturation.