bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetics and Outcome of Atypical Hemolytic Uremic Syndrome
Authors: Fremeaux-Bacchi Véronique , Fakhouri Fadi , Garnier Arnaud , Bienaimé Frank , Dragon-Durey Marie-Agnès , Ngo Stéphanie , Moulin Bruno , Servais Aude , Provot François , Rostaing Lionel , Burtey Stéphane , Niaudet Patrick , Deschênes Georges , Lebranchu Yvon , Zuber Julien , Loirat Chantal 
Published: January 2013

Summary

Background and objectives
Atypical hemolytic uremic syndrome (aHUS) is a rare complement-mediated kidney disease that was first recognized in children but also affects adults. This study assessed the disease presentation and outcome in a nationwide cohort of patients with aHUS according to the age at onset and the underlying complement abnormalities.

Design, setting, participants, & measurements
A total of 214 patients with aHUS were enrolled between 2000 and 2008 and screened for mutations in the six susceptibility factors for aHUS and for anti–factor H antibodies.

Results
Onset of aHUS occurred as frequently during adulthood (58.4%) as during childhood (41.6%). The percentages of patients who developed the disease were 23%, 40%, 70%, and 98% by age 2, 18, 40, and 60 years, respectively. Mortality was higher in children than in adults (6.7% versus 0.8% at 1 year) (P=0.02), but progression to ESRD after the first aHUS episode was more frequent in adults (46% versus 16%; P<0.001). Sixty-one percent of patients had mutations in their complement genes. The renal outcome was not significantly different in adults regardless of genetic background. Only membrane cofactor protein (MCP) and undetermined aHUS were less severe in children than adults. The frequency of relapse after 1 year was 92% in children with MCP-associated HUS and approximately 30% in all other subgroups.

Conclusion
Mortality rate was higher in children than adults with aHUS, but renal prognosis was worse in adults than children. In children, the prognosis strongly depends on the genetic background.
Camouflage treatment of skeletal Class III malocclusion with multiloop edgewise arch wire and modified Class III elastics by maxillary mini-implant anchorage
Authors: He Shushu , Gao Jinhui , Wamalwa Peter , Wang Yunji , Zou Shujuan , Chen Song 
Published: January 2013

ABSTRACT

Objective:
To evaluate the effect of the multiloop edgewise arch wire (MEAW) technique with maxillary mini-implants in the camouflage treatment of skeletal Class III malocclusion.

Materials and Methods:
Twenty patients were treated with the MEAW technique and modified Class III elastics from the maxillary mini-implants. Twenty-four patients were treated with MEAW and long Class III elastics from the upper second molars as control. Lateral cephalometric radiographs were obtained and analyzed before and after treatment, and 1 year after retention.

Results:
Satisfactory occlusion was established in both groups. Through principal component analysis, it could be concluded the anterior-posterior dental position, skeletal sagittal and vertical position, and upper molar vertical position changed within groups and between groups; vertical lower teeth position and Wits distance changed in the experimental group and between groups. In the experimental group, the lower incisors tipped lingually 2.7 mm and extruded 2.4 mm. The lingual inclination of the lower incisors increased 3.5°. The mandibular first molars tipped distally 9.1° and intruded 0.4 mm. Their cusps moved 3.4 mm distally. In the control group, the upper incisors proclined 3°, and the upper first molar extruded 2 mm. SN-MP increased 1.6° and S-Go/N-ME decreased 1.

Conclusions:
The MEAW technique combined with modified Class III elastics by maxillary mini-implants can effectively tip the mandibular molars distally without any extrusion and tip the lower incisors lingually with extrusion to camouflage skeletal Class III malocclusions. Clockwise rotation of the mandible and further proclination of upper incisors can be avoided. The MEAW technique and modified Class III elastics provided an appropriate treatment strategy especially for patients with high angle and open bite tendency.
Symptomatic multipartite patella: imaging findings and pain relief. A description of two cases
Authors: Perdikakis Evangelos , Pothitakis Chrysovalantis 
Published: January 2013

Abstract
Musculoskeletal injuries in the non-elite athletes are a clinical entity that is being seen more frequently nowadays. The term “weekend warriors” applies to amateur participants in sports activities and is related to an increasing number of musculoskeletal injuries mainly due to overuse. Concomitant skeletal variations may as well predispose to trauma. We add to the literature two cases of multipartite patella in which locally injected ropivacaine (ropivacaine hydrochloride) and steroid (betamethasone acetate-betamethasone sodium phosphate) relieved the symptoms completely. Here, we describe the clinical, imaging features and the course of treatment.
Chemical robotics — chemotactic drug carriers
Authors: Lagzi István 
Published: January 2013

Abstract
In this review we show and describe a concept of designing autonomously moving artificial cells (chemical robots) carrying drugs and having tactic behavior based on artificial chemotaxis. Such systems could help to provide new and more efficient drug delivery applications. Chemical robot can be constructed based on the self-organization — natural “bottom-up” way — of fatty acid or lipid molecules into ordered nano- or micrometer size objects that have the ability to move and respond to environmental stimuli. The idea of using tactic carriers in drug delivery applications can be justified by the fact that cancer sites in the living body have different physiological characters (lower pH and higher resting temperature) compared to normal cells. The proposed “bottom-up” design method for self-propelled objects at small scales for targeted drug delivery applications could realize the original designation of nanoscience proposed 50 years ago by Richard Feynman.
Biodiversität im Wald: Konzept und Methode der Erfolgskontrolle im Kanton Thurgau
Authors: Schmider Peter , Bernowitz Karin 
Published: January 2013

Forest biodiversity: concept and methods of succes monitoring in the canton Thurgau
In the canton of Thurgau about 1,700 ha of forest reserves have been established. Of these, about 250 ha are unmanaged forests. In the 1,450 ha of special forest reserves, the Forestry Department of the canton Thurgau undertakes specific measures to promote forest biodiversity, which will be intensifed in the coming years. The effects will be observed by means of success monitoring. In the article, we present the concept “biodiversity: success monitoring in forest”, which was developed in 2009 and which implements a standardized method for the success monitoring. It is based on forest target types which are defined by ecological objectives. To assess the bio-ecological conditions of a research area or to verify the achievement of objectives, characteristic and rare plants and animal species as well as habitat structures were defined as indicators in each forest target type. The success monitoring is carried out on ten sites of 1 ha each per forest type. Within these areas there are permanent plots with defined sizes. The indicators are monitored either on the 1 ha site or the smaller permanent plots. Since the beginning of 2010, success monitoring is conducted according to this concept. During the first phase, monitoring is concentrated on the relevant forest target types in the canton of Thurgau: “open forest”, “oak-dominated forest with old oaks”, “alluvial forest” and “forest margins”. Success monitoring will continue until 2020. Results and key findings of the monitoring are annually documented in a report.
Flächenhafte Modellierung von Waldboden-eigenschaften in der Nordwestschweiz
Authors: Mosimann Thomas , Herbst Philipp 
Published: January 2013

Spatial modeling of forest soil properties in Northwestern Switzerland
Forest soils are an important natural resource. However, up to now almost no area-wide forest soil information was available for Switzerland. Since 2006, model-based, high-resolution maps of forest soil properties in the cantons Basel-Landschaft and Basel-Stadt were generated, depicting soil depth, stone content, soil wetness, acidity and water storage capacity. These maps are based on all available point information on soils, and on 95 recently analyzed pedological forest soil profiles. Two different methods were applied in parallel: 1) the development of decision trees based on frequency statistics combined with expertise and 2) the semi-automated Random Forest modeling approach. Highly branched hierarchical decision trees were used to derive soil properties from 24 predictors (relief forms, parent material, vegetation, forest type, location, climate, etc.). This article describes the approaches and portrays the mapped results of soil depth, top soil acidity and water storage capacity. Our project shows that it is basically feasible to predict soil properties with a high spatial resolution, classifying them into 4–5 categories. However, depending on soil type, for 10–30% of the area no predictions are possible, especially because of high soil heterogeneity, inadequate morphographic slope differentiation in the terrain models and the implausibility of predictor information. Soil property maps provide basic information for set up forestry maps for forest development, forest management and risk assessment.
Identités et dilemmes de l'enseignant-chercheur en sciences comptables
Authors: Dupuy Yves , Lacroix Monique , Naro Gérald 
Published: January 2013

Cet article porte sur les questionnements identitaires de l’enseignant-chercheur en sciences comptables. Enseignant et chercheur à la fois, ce dernier en quête d’identité est confronté à plusieurs dilemmes de nature épistémologique et didactique, le conduisant à un « va et vient » entre recherche et pédagogie. Envisagé comme un relais des pratiques comptables, l’enseignant-chercheur en comptabilité, contrôle, audit, peut s’identifier comme un traducteur mimétique et un agent légitimateur de ces pratiques. En même temps, il apparaît également comme un constructeur de théories comptables. En quête de lectures théoriques, c’est dans les fondamentaux économiques et organisationnels, que le chercheur peut construire les bases de son enseignement.
La construction d'une façade légaliste en contexte répressif
Authors: Codaccioni Vanessa 
Published: January 2013

Cet article analyse la manière dont une partie du groupe dirigeant communiste construit progressivement, pendant la guerre d’Algérie, une façade légaliste destinée à éviter la répression, à intégrer le champ politique et à préserver un électorat favorable à l’Algérie française. Il s’agit dès lors d’insister sur le caractère processuel de la mise en forme du PCF entre 1954 et 1956, de restituer ses conditions sociales de possibilité mais aussi d’analyser son imposition aux membres du PCF, et en particulier à ceux qui veulent engager une contestation plus radicale contre le conflit algérien.
Comparison of Postoperative Vault Height Predictability Using White-to-White or Sulcus Diameter–based Sizing for the Visian Implantable Collamer Lens
Authors: Reinstein Dan Z. , Lovisolo Carlo F. , Archer Timothy J. , Gobbe Marine 
Published: January 2013

PURPOSE:
To compare vault height predictability of Implantable Collamer Lens (ICL; Staar Surgical) sizing using a sulcus diameter–based formula or the manufacturer-recommended white-to-white–based method.

METHODS:
In 50 myopic eyes, ICL size was calculated using both a formula including sulcus diameter and the traditional formula based on white-to-white diameter. Sulcus diameter was measured using Artemis 2 very high-frequency (VHF) digital ultrasound (ArcScan Inc). Implantation was based on the sulcus diameter derived size. Actual postoperative vault height achieved was measured by VHF digital ultrasound scanning. Circle segment trigonometry was used to calculate the vault height that would have resulted had lens sizing been based on the white-to-white formula.

RESULTS:
The same lens size would have been used in 60% of eyes, a smaller lens would have been used in 34% of eyes and a larger lens in 6% of eyes had lens sizing been based on the white-to-white formula. Mean vault for eyes with lenses sized using the sulcus diameter formula was 0.37±0.16 mm (range: 0.08 to 0.92 mm), with 2% <0.09 mm, the recognized low-vault height for risk of cataract. Circle segment trigonometry predicted that the vault height would have been 0.24±0.28 mm (range: −0.31 to 0.92 mm), with 26% <0.09 mm had lens sizing been based on the white-to-white formula.

CONCLUSIONS:
Significantly better predictability of postoperative vault height was achieved by including sulcus diameter into the ICL sizing formula compared with using the traditional white-to-white–based formula.
Effect of Experimentally Induced Astigmatism on Functional, Conventional, and Low-Contrast Visual Acuity
Authors: Watanabe Kazuhiro , Negishi Kazuno , Kawai Miho , Torii Hidemasa , Kaido Minako , Tsubota Kazuo 
Published: January 2013

PURPOSE:
To report the changes in functional visual acuity (FVA) in eyes with experimentally induced astigmatism.

METHODS:
This study included 26 right eyes from 26 healthy participants (mean age: 27.0±4.4 years). After confirming best correction under cycloplegia, the cylinder power ×90° and ×180° (against-the-rule [ATR] and with-the-rule [WTR] astigmatism, respectively) were added with 0.50-diopter (D) steps, from 0.50 to 2.50 D. Conventional visual acuity (VA), FVA as measured by the FVA Measurement System (NIDEK Co Ltd), and 10% low-contrast visual acuity (LCVA) were measured with 3-mm artificial pupil under each condition.

RESULTS:
The mean corrected logMAR VA, FVA, LCVA were −0.18±0.00 (20/13), −0.10±0.08 (20/16), and 0.06±0.06 (20/23), respectively. The VA, FVA, and LCVA had a significant linear negative correlation with the addition of cylinder irrespective of the axes. A significant decrease in FVA was noted on addition of ⩾0.50 D WTR astigmatism and ⩾1.00 D ATR astigmatism. With the addition of 1.00 D of cylindrical lens, 96% of eyes with WTR and ATR astigmatism could maintain 20/20 in VA testing, whereas only 50% and 62% of eyes with WTR and ATR astigmatism, respectively, could maintain 20/20 in FVA testing.

CONCLUSIONS:
Astigmatism may be associated with deterioration of visual function even when conventional VA of 20/20 is attained. Functional VA testing seems to be useful in evaluating the masked astigmatic visual impairment that cannot be detected by conventional VA testing.
The forked flap repair for hypospadias
Authors: Chadha Anil , Singh Amitabh 
Published: January 2013

ABSTRACT
Context: Despite the abundance of techniques for the repair of Hypospadias, its problems still persist and a satisfactory design to correct the penile curvature with the formation of neourethra from the native urethral tissue or genital or extragenital tissues, with minimal postoperative complications has yet to evolve. Aim: Persisting with such an endeavor, a new technique for the repair of distal and midpenile hypospadias is described. Materials and Methods: The study has been done in 70 cases over the past 11 years. The "Forked-Flap" repair is a single stage method for the repair of such Hypospadias with chordee. It takes advantage of the rich vascular communication at the corona and capitalizes on the established reliability of the meatal based flip-flap. The repair achieves straightening of the curvature of the penis by complete excision of chordee tissue from the ventral surface of the penis beneath the urethral plate. The urethra is reconstructed using the native plate with forked flap extensions and genital tissue relying on the concept of meatal based flaps. Water proofing by dartos tissue and reinforcement by Nesbit′s prepucial tissue transfer completes the one stage procedure. Statistical Analysis: An analysis of 70 cases of this single stage technique of repair of penile hypospadias with chordee, operated at 3 to 5 years of age over the past 11 years is presented. Results and Conclusion: The Forked Flap gives comparable and replicable results; except for a urethrocutaneous fistula rate of 4% no other complications were observed.
Plastic surgical trauma: A single-centre experience
Authors: Khan Mansoor , Aziz Asif , Naz Shazia , Khan Imran M. , Ullah Atif , Ullah Hidayat , Ullah Tahmeed , Tahir Muhammad 
Published: January 2013

ABSTRACT
Objectives: To analyse the demographics, mechanism, nature, anatomical distribution, management and complications in trauma patients presenting to the plastic surgery unit. Study Design: Descriptive cross-sectional study. Setting: This study was conducted in the Plastic and Reconstructive Surgery Unit, Hayatabad Medical Complex, Peshawar, from 1 st January 2009 to 30 th April 2012. Materials and Methods: All trauma patients referred from emergency department and other departments irrespective of age and gender were enrolled in the study, excluding acute burns and trauma sequelae patients. The details were obtained from the data sheets of the patients. All the data were analysed and projected in the form of tables and figures. Results: A total of 1034 patients including 855 (82.7%) males and 179 (17.3%) females presented with plastic surgical trauma, with age ranging from 1 to 86 years, with a mean age of 20.84 ± 15.469 SD. The upper limb was affected in 492 (47.6%) patients, followed by head and neck in 273 (26.4%) cases. Road traffic accidents (RTAs) were the main cause of trauma, affecting 340 (32.9%) patients. Wound excision and closure was performed in 473 (45.7%) patients, followed by skin grafting and flap coverage in 232 (22.4%) and 132 (13.2%) patients, respectively. Postoperative complications were observed in 45 (4.35%) patients. Conclusion: Males in their young age mainly presented with plastic surgical trauma with RTA as the main mechanism and laceration as the most common type of these injuries. The upper limb was the most commonly affected region. The frequency of different types of surgical procedures and postoperative complications observed are comparable with international literature except for the microvascular surgery which is not performed in our centre. Regular audit of the plastic surgical trauma should be conducted in all plastic surgical units to both improve trauma care and reaffirm the role of Plastic Surgery in the new age trauma.
<b>Educação socioambiental, imaginário e Artes Visuais</b>
Authors: Ormezzano Graciela René , Poma Silviani Teixeira 
Published: January 2013

http://dx.doi.org/10.5902/198464443499 Este artigo surge de uma pesquisa bibliográfica que opta pela cosmovisão estética proposta por Maffesoli e fala do imaginário social como fundamento para o estudo. Ainda faz um breve levantamento de algumas políticas públicas educacionais que favorecem a educação ambiental e a transversalidade e, por fim, discute a relevância das artes visuais no processo de ensino-aprendizagem transdisciplinar realizando uma proposta metodológica que se considera apta a ser desenvolvida nos diversos níveis de ensino formal ou na educação não formal. O modo de execução sugerido está fundamentado no emprego de oficinas como metodologia pedagógica, juntando as artes visuais dos vários campos do saber com os quais pode se relacionar ao tratar o tema da educação socioambiental. A proposta trata da necessidade de se voltar para a experiência inventiva com a finalidade de (re)descobrir a ação de educar e de educar-se sem perder de vista a totalidade. Busca o sentido da vida em sociedade, transformando a percepção humana do Cosmos, respeitando o ambiente natural e a complementaridade das múltiplas culturas. Palavras-chave: educação socioambiental, imaginário, artes visuais.
<b>Pensando sobre a aprendizagem de conceitos em sala de aula</b>
Authors: Carlino Eliana Prado 
Published: January 2013

http://dx.doi.org/10.5902/198464444476 Muitas são as teorias de aprendizagem a subsidiar a atividade do professor, quando ele se propõe a trabalhar um determinado conhecimento ou conceito em sala de aula. A partir desses referenciais teóricos que circulam nos espaços educacionais e embasam, ainda que implicitamente, o fazer docente, surgiu nossa preocupação com o processo de ensino e as relações estabelecidas com a/pela linguagem na aprendizagem de conceitos. Procuramos, neste artigo, explicitar o movimento que ocorre por meio das inter-relações envolvendo alunos, professores e conhecimentos. Assim, apresentamos aqui a dinamicidade de que se reveste o trabalho de elaboração conceitual, no qual os sentidos produzidos nem sempre são aqueles previstos na intencionalidade do professor. Essa não convergência, contudo, não torna essa produção equivocada ou incorreta, mas faz parte da dinâmica que caracteriza a linguagem e a produção de sentidos. Para evidenciar esse processo, embasamos nossas considerações em Vygotsky e Bakhtin, por terem o signo e a linguagem como centralidade em suas elaborações teóricas e por considerarem a dialogia como princípio das interações humanas. Palavras-chave: conceito; linguagem; sentido
<b>Produções do invisível: considerações sobre o tempo e a formação de professores</b>
Authors: Dalmaso Alice , Sangoi Deisi 
Published: January 2013

http://dx.doi.org/10.5902/198464444493 O presente texto se propõe a abordar, mesmo que brevemente, a temática da invenção no âmbito da formação de professores. Para tanto, faremos um apanhado das contribuições de Virgínia Kastrup a esse respeito, trazendo a questão do tempo – através da problematização de duração, de Henri Bergson – e seu emprego na temática da formação. A partir disso, tentaremos desconstruir um olhar de referência identitária na contemporaneidade para modos de existência que se percebem múltiplos e abertos. Na processualidade que se trata em explicar, nos movimentos inventivos que funcionam com ela, o tempo é considerado como expressão da dimensionalidade do ser individuando-se. Ou seja, durar refere-se a uma imediatidade do ser, do tempo de ser, que é modulável, mutante, sempre em devir, sempre em criação. Na construção de produzir um corpo que abandona uma referência identitária – que diverge com a transformação de si – inevitavelmente reportamo-nos à relação da ideia de tempo como duração com a operação de individuação de Gilbert Simondon. É do intercruzamento destes conceitos, e sua possível ressonância no debate que concerne a políticas formativas, que se pode desenvolver um olhar do invisível a uma formação de professores, de aprendizes de outros modos de operar no mundo. A invenção como alavanca nos direciona a um campo de possibilidades de conceber e vivenciar um outro tempo (e espaço) que é ele mesmo produção de subjetividades, singularidades e diferenças. Palavras-chave: tempo, individuação, formação de professores.
<b>Cultura escrita: aprender a ler e escrever na escola</b>
Authors: Bolzan Doris Pires Vargas , Santos Eliane Aparecida Galvão dos , Powaczuk Ana Carla Hollweg 
Published: January 2013

http://dx.doi.org/10.5902/198464446095 Este texto discute os aspectos formais da escrita e da leitura no contexto da sala de aula, destacando a importância do protagonismo dos estudantes, favorecendo sua autoria como escritores e leitores a partir da cultura escrita. Compreendemos que é indispensável que a escola tenha uma visão prospectiva em relação às aprendizagens dos estudantes, ou seja, que valorize suas poten-cialidades, levando em conta a cultura na qual estão inseridos. Colocamos em relevo o papel do alfabetizador no processo de organização do trabalho pedagógico, voltado ao ensino e à aprendizagem da lectoescrita dos estudantes nos anos iniciais do Ensino Fundamental. Nesse sentido, destacamos que a organização do ensino exige investimento docente em direção ao aprimoramento dos fazeres e saberes que incidem na organização do trabalho pedagógico, demarcando um longo caminho a percorrer, de modo a permitir a assunção do protagonismo pedagógico. Palavras-chave: alfabetização; cultura escrita; atividades diversificadas.