bluuebunny/crossref_metadata_2025_split huggingface dataset:
An archive‐based method for efficiently handling small file problems in HDFS
Authors: Liu Junnan , Jin Shengyi , Wang Dong , Li Han 
Published: August 2024

SummaryHadoop distributed file system (HDFS) performs well when storing and managing large files. However, its performance significantly decreases when dealing with massive small files. In response to this problem, a novel archive‐based solution is proposed. The archive refers to merging multiple small files into larger data files, which can effectively reduce the memory usage of the NameNode. The current archive‐based solutions have the disadvantages of long access time, long archive construction time, and no support for storage, updating and deleting small files in the archive system. Our method utilizes a dynamic hash function to distribute the metadata of small files across multiple metadata files. We construct a primary index that combines dynamic and static indexes for these metadata files. Regarding data files, include some read‐only files and one readable–writable file. A small file's contents are written into a readable and writable file. Upon reaching a predetermined threshold, the readable–writable file transitions into read‐only status, with a fresh readable–writable file replacing it. Experimental results show that the scheme improves the efficiency of archive access and archive creation and is more efficient than the original HDFS storage and update efficiency.
Toward the development of a cross‐compatibility framework to enhance the utilization of peanut CWRs
Authors: García A. V. , Chalup L. , Seijo J. G. 
Published: August 2024

AbstractUtilizing valuable genes and alleles from crop wild relatives (CWRs) and transferring them to elite varieties requires a thorough understanding of species cross compatibility and reproductive systems. In this review, we examine interspecific crossing among peanut CWRs, chromosome pairing during meiosis, and pollen viability of Filial 1 hybrids. We analyze each parameter in relation to phylogenetic distances and current taxonomic and genomic classification, aiming to develop a cross‐compatibility scheme for the crop's secondary gene pool. Analysis of passport information and species names from research groups worldwide over the past 60 years revealed diverse frequencies of genome combinations (17) and species (26) used in hybridization assays. However, only eight species accounted for nearly 50% of successful hybridizations. In intragenomic hybrids, bivalent frequency ranged from 9.1 to 10, with pollen viability typically between 30% and 60%. Intergenomic hybrids exhibited bivalent frequency between 4.8 and 8.5, with pollen viability below 10%. Outliers were observed in the various parameters and hybrids were analyzed. Phylogenetic distance presented an inverse relationship with all variables; the correlation was low with crossing success while moderate with bivalent frequency and pollen viability. These findings suggest that differences in DNA sequences are not the sole determinants of interspecific cross‐compatibility, indicating the presence of pre‐ or postzygotic hybridization barriers. This organized information is crucial for establishing a framework to facilitate the rational selection of parents with desired traits and appropriate genome combinations, ultimately aiding in the development of new amphidiploids compatible with peanut varieties.
Tirbanibulin (KX2‐391) analog KX2‐361 inhibits botulinum neurotoxin serotype A mediated SNAP‐25 cleavage in pre‐ and post‐intoxication models in cells
Authors: Koc Dilara , Ibis Kubra , Besarat Peri , Banoglu Erden , Kiris Erkan 
Published: August 2024

AbstractBotulinum neurotoxins (BoNT) inhibit neuroexocytosis, leading to the potentially lethal disease botulism. BoNT serotype A is responsible for most human botulism cases, and there are no approved therapeutics to treat already intoxicated patients. A growing body of research has demonstrated that BoNT/A can escape into the central nervous system, and therefore, identification of BoNT/A inhibitors that can penetrate BBB and neutralize the toxin within intoxicated neurons would be important. We previously identified an FDA‐approved, orally bioavailable compound, KX2‐391 (Tirbanibulin) that inhibits BoNT/A in motor neuron assays. Recently, a structural analog of KX2‐391, KX2‐361, has been shown to exhibit good oral bioavailability and cross BBB with high efficiency in mouse experiments. Therefore, in this work, we evaluated the inhibitory effects of KX2‐361 against BoNT/A. Toward this goal, we first evaluated the compound for its effects on cell viability in PC12 cells, via MTT assay, and in mouse embryonic stem cell (mESC)‐derived motor neurons, with imaging‐based assays. Following, we tested KX2‐361 in mESC‐derived motor neurons intoxicated with BoNT/A holotoxin, and the compound exhibited activity against the toxin in both pre‐ and post‐intoxication conditions. Excitingly, KX2‐361 also inhibited BoNT/A enzymatic component (light chain; LC) in PC12 cells transfected with BoNT/A LC. Furthermore, our molecular docking analyses suggested that KX2‐361 can directly bind to BoNT/A LC. Medicinal chemistry approaches to develop structural analogs of KX2‐361 to increase its efficacy against BoNT/A may provide a critical lead compound with BBB penetration capacity for drug development efforts against BoNT/A intoxication.
Annual temperature, body size, and sexual size dimorphism in the evolution of Pyrgomorphidae
Authors: Cueva del Castillo Raúl , Sanabria‐Urbán Salomón , Mariño‐Pérez Ricardo , Song Hojun 
Published: August 2024

AbstractIn many animal species, larger body size is positively correlated with male mating success and female fecundity. However, in the case of insects, in high seasonality environments, natural selection favors a faster maturation that decreases the risk of pre‐reproductive death. However, this advantageous adaptation comes at a tradeoff, resulting in a reduction in body size. Maturation time is influenced by environmental factors, such as temperature, season length, and food availability during the rains. The geographic variation in these parameters provides an opportunity to study their impact on the adaptive evolution of body size in Pyrgomorphidae grasshoppers. These grasshoppers exhibit remarkable variation in body size and wing development and can be found in diverse plant communities across Africa, Asia, Australia, and tropical America. In this study, we utilized a phylogenetic approach to examine the evolution of body size, considering climatic factors, and the influence of sexual selection on size differences between males and females. We found a positive correlation between mean annual temperature and sexual size dimorphism (SSD). Remarkably, species exhibiting a strong bias toward larger females were found to be adapted to regions with higher temperatures. In the Pyrgomorphidae family, an intermediate body size was identified as the ancestral trait. Additionally, winged male and female grasshoppers were observed to be larger than their wingless counterparts. Despite the potential conflicting pressures on body size in males and females, these grasshoppers adhere to Rench's Rule, suggesting that sexual selection on males' body size may explain the evolution of SSD.
Continuous daily sampling of airborne eDNA detects all vertebrate species identified by camera traps
Authors: Polling Marcel , Buij Ralph , Laros Ivo , de Groot G. Arjen 
Published: August 2024

AbstractOngoing pressures on global biodiversity require conservation action that is not possible without effective biomonitoring. Terrestrial vertebrate surveys are commonly performed using camera traps, a time‐intensive method known to miss many small or arboreal species and birds. Recent advances have shown airborne eDNA to be a potentially suitable technique to more effectively monitor vertebrate communities in a time‐ and cost‐effective manner. Here, we test whether commercially available air samplers that collect air particles 24/7 during a 1‐week period can be used to detect the presence of vertebrates through airborne eDNA. The results are compared to camera trap records at three locations with differing habitats in the Netherlands. Simultaneous sampling with three different air samplers for 3 weeks resulted in detection of 154 vertebrate taxa, of which the majority were birds or mammals (113 and 33 species, respectively), along with four fish and four amphibian species. All species observed using camera traps were also retrieved via airborne eDNA, although not on every day of sampling. The Burkard spore trap, used routinely for pollen monitoring, showed the highest number of vertebrate species, and only in three samples when a mammal species was detected using a camera trap it remained undetected via eDNA. We also detected unique species at the three locations using airborne eDNA, indicative of the habitat in which they were living. However, we also detected species that we could not account for. The multitude of species found using airborne eDNA compared to camera traps indicate the sensitivity of the method; however, subsequent studies should prioritize validation of these findings through alternative biomonitoring approaches.
Effectiveness of exercise interventions, alone or in combination with dietary modifications, on working memory in overweight and obese individuals: A systematic review
Authors: Cristi‐Montero Carlos , Barriga Victoria , Peña‐Jorquera Humberto , Martínez‐Flores Ricardo , Espinoza‐Puelles Juan Pablo , Flores Olivares Luis Alberto , Quintana Mendias Estefania , Enriquez‐del Castillo Liliana Aracely 
Published: August 2024

AbstractThis systematic review aimed to establish the effectiveness of exercise interventions, alone or in combination with dietary modifications, on working memory (WM) in individuals living with overweight and obesity. A comprehensive literature search was conducted using the Scopus, PubMed, Springer‐Link, RefSeek, and Cochrane Library databases to identify relevant publications up to January 18, 2024. Data on participants' characteristics, intervention settings, and key outcomes related to WM were extracted. The quality of the studies was assessed using the PEDro scale. A total of 15 articles met pre‐established inclusion criteria, involving participants across nine countries with a range of 12–125 individuals and ages spanning from 6 to 80 years old. Among the studies analyzed, 10 exclusively investigated exercise interventions, whereas five explored the combined effects. Notably, 70% of the exercise interventions (7 out of 10) exhibited positive improvements in WM. Likewise, 60% of the combined interventions (3 out of 5) demonstrated favorable enhancements in WM. No differences were found between the two protocols. Common features between the protocols were identified and described. Both protocols showed favorable and promising effects on WM in this clinical population. Nonetheless, the limited evidence addressing the combination of exercise and diet in the same research approach reduces the generalizability of the findings. This review offers valuable insights for future clinical and research applications in people with overweight and obesity.
A Cost‐Effective Electrochemical Sensor Using a Graphite Pencil Electrode for Sensitive Quantification of Phenolic Antioxidants in Human Plasma and Food Samples
Authors: Bakr Ahmed , Newair Emad F. , Ismael Mohamed , Khairy Mohamed 
Published: August 2024

AbstractThe pressing challenge in electroanalysis revolves around the creation of a user‐friendly analytical sensor that is accessible to individuals lacking specialized expertise. Such sensor should offer minimal cost, while simultaneously ensuring high sensitivity and reproducibility. Herein, graphite pencil electrode (GPE) has emerged as a promising electrochemical sensor for the determination of polyphenolic compounds, including gentisic acid (GEN), gallic acid (GA), caffeic acid (CAF), and sinapic acid (SA). To comprehensively explore the electrochemical oxidation processes of these antioxidants, a range of electrochemical techniques, namely cyclic voltammetry (CV), differential pulse voltammetry (DPV), and chronoamperometry (CA), were deployed. The results of these investigations unveiled a diffusional oxidation wave associated with phenolic hydroxyl groups, involving a two‐electron/two‐proton loss step, occurring within the potential range of 0.4–0.6 V vs. Ag/AgCl. Crucially, the GPE exhibited the capacity to establish linear calibration curves for GEN, GA, CAF, and SA, encompassing concentrations from nanomolar to sub‐micromolar which highlighted by the corresponding limits of detection (LoD), recorded at 0.086, 0.046, 0.112, and 0.115 μM, respectively. The heightened sensitivity and reproducibility demonstrated by the GPE underscore its potential as an efficient tool for the determination of polyphenolic compounds. Beyond its analytical capabilities, the GPE displayed remarkable applicability in facilitating on‐site, cost‐effective determinations of polyphenolic compounds in both plasma and food samples. This versatility positions the GPE as a valuable asset in addressing the challenges associated with electrochemical analysis, making it an attractive option for a wide range of applications where simplicity, affordability, and reliability are paramount.
High‐Performance Single‐Phase Bi‐Directional Novel On‐Board Charger for Electric Vehicles
Authors: Ali Md Inayat , Mandal Rajib , Kumar Amitesh 
Published: August 2024

ABSTRACTThe design and development of a 550 W non‐isolated single‐phase two‐stage level‐1 bidirectional on‐board battery charger (OBC) for electric vehicles (EVs) have been discussed in this article, which is also capable of supplying the utility grid's reactive power needs. There are two stages in this topology. The first stage consists of a full bridge bidirectional AC to DC converter, and the second stage consists of a half‐bridge bidirectional DC to DC converter with enhanced vehicle‐to‐vehicle (V2V) capabilities for emergency roadside charging assistance scenarios. In an emergency, if there is not a charging station nearby and the battery is dead, EVs can use this feature to charge from other EVs. It can also work like a regular vehicle‐to‐grid (V2G) or grid‐to‐vehicle (G2V) system. The suggested charging topology has a maximum efficiency of 99.09%, a power factor of 0.99, and a total harmonic distortion (THD) of 6.31%. MATLAB/Simulink is used to develop and simulate the suggested EV charger, and simulation results are compared with the other on‐board chargers in the literature.
Electric Vehicle Smart‐Charging Control for Parking Lots Based on Individual State of Charge Priority
Authors: Haasis Frederico , Solano Oscar , Dias Daniel , Borba Bruno 
Published: August 2024

ABSTRACTThe integration of electric vehicles (EVs) into the power grid could pose challenges to power quality (PQ) depending on quantity of EVs and when they are connected. To mitigate these impacts without using drastic measures, such as disconnecting EVs, this study investigates centralized control strategies within parking facilities that prioritize EV charging based on individual State of Charge (SoC) levels. The study utilizes the IEEE 34 Bus system and conducts 3888 simulations for different scenarios to assess the impact of the quantity and placement of EVs in parking lots. The study applies the Monte Carlo method to compare the performance of different proposed controls: (i) limiting the charging current to a fixed level and (ii) varying the current based on the voltage droop step. Furthermore, Power Hardware‐in‐the‐Loop (PHIL) simulations were carried out to validate the hierarchical control using the droop step control, demonstrating the best average performance in the previous scenarios. The findings indicated that the control responded within the expected timeframe and successfully addressed voltage sag issues, maintaining PQ in the distribution system in most cases, with its performance being influenced by the placement of parking lots in the network. Additionally, it was confirmed through quartiles that the classification based on SoC leads to a more balanced charging time for different SoC levels.
Accumulation of Parabens, Their Metabolites, and Halogenated Byproducts in Migratory Birds of Prey: A Comparative Study in Texas and North Carolina, USA
Authors: Rojo Macarena , Ball Ashley L. , Penrose Mike T. , Weir Scott M. , LeBaron Hailey , Terasaki Masanori , Cobb George P. , Lavado Ramon 
Published: August 2024

Abstract
Parabens are alkyl esters of p-hydroxybenzoic acid that are commonly used as preservatives in personal care products such as cosmetics. Recent studies have revealed the presence of parabens in surface and tap water because of their use as disinfection products; however, little is known about their occurrence in biological samples and their bioaccumulation potential, particularly in raptor birds known as sentinels for pollutant detection. We examined the occurrence and tissue distribution of parabens, their metabolites, and halogenated byproducts in the liver, kidney, brain, and muscle of birds of prey from Texas and North Carolina (USA). Methylparaben (MeP), propylparaben (PrP), and butylparaben (BuP) were detected in more than 50% of all tissues examined, with the kidney exhibiting the highest concentration of MeP (0.65–6.84 ng/g wet wt). Para-hydroxybenzoic acid (PHBA), a primary metabolite, had the highest detection frequency (&gt;50%) and a high accumulation range in the liver, of 4.64 to 12.55 ng/g. The chlorinated compounds chloromethylparaben and chloroethylparaben were found in over half of the tissues, of which dichloromethylparaben (2.20–3.99 ng/g) and dichloroethylparaben (1.01–5.95 ng/g) in the kidney exhibited the highest concentrations. The dibrominated derivatives dibromideethylparaben (Br2EtP) was detected in more than 50% of samples, particularly in muscle and brain. Concentrations in the range of 0.14 to 17.38 ng/g of Br2EtP were detected in the kidney. Dibromidepropylparaben (Br2PrP) was not frequently detected, but concentrations ranged from 0.09 to 21.70 ng/g in muscle. The accumulations of total amounts (sum) of parent parabens (∑P), metabolites (∑M), and halogenated byproducts (∑H) in different species were not significantly different, but their distribution in tissues differed among the species. Positive correlations were observed among MeP, PrP, BuP, and PHBA in the liver, suggesting similar origins and metabolic pathways. Environ Toxicol Chem 2024;43:2365–2376. © 2024 The Author(s). Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
The potential of Gynostemma pentaphyllum in the treatment of hyperlipidemia and its interaction with the LOX1‐PI3K‐AKT‐eNOS pathway
Authors: Shen Zhuyang , Gao Xin , Huang Dan , Xu Xiaojin , Shen Jianping 
Published: August 2024

AbstractGynostemma pentaphyllum, a traditional Chinese medicine, is widely used to treat various diseases, but its therapeutic effects and mechanisms of action on hyperlipidemia remain unclear. This study aims to investigate the effects of Danshen leaf on hyperlipidemia through network pharmacology, molecular docking, and cellular experiments, elucidating its multifaceted mechanism of action within the LOX1‐PI3K‐AKT‐eNOS pathway. First, the active ingredients and targets of G. pentaphyllum were screened using the Traditional Chinese Medicine Systems Pharmacology database. Then, targets for hyperlipidemia were identified using the OMIM and GeneCards databases, and potential therapeutic targets for G. pentaphyllum in treating hyperlipidemia were determined. An active ingredient‐target network was constructed using Cytoscape software, and a protein–protein interaction (PPI) network was built and visualized using the STRING database and Cytoscape software. Finally, GO functional and KEGG pathway enrichment analyses were performed, and the predicted mechanisms were validated through molecular docking and cell experiments. 85 targets for G. pentaphyllum and 1556 for Hyperlipidemia were screened, with 53 common targets. Twenty‐four active ingredients of G. pentaphyllum were found to be involved in the treatment of hyperlipidemia. Key nodes such as Rhamnazin, Isofucosterol, and quercetin, and targets NCOA2, NR3C2, PGR, and PPARG showed high relevance. In the PPI network, 8 nodes, including IL6, PPARG, and VEGFA, exhibited high centrality. GO functional and KEGG pathway enrichment analyses indicated that G. pentaphyllum may treat hyperlipidemia by influencing various biological functions and pathways, such as DNA‐binding transcription factor binding, RNA polymerase II‐specific DNA‐binding transcription factor binding, and lipid and atherosclerosis. Cell experiments demonstrated that G. pentaphyllum significantly regulated the expression of key proteins in the LOX1‐PI3K‐AKT‐eNOS pathway, thereby improving hyperlipidemia. G. pentaphyllum improves hyperlipidemia by mediating the LOX1‐PI3K‐AKT‐eNOS pathway. This study provides a new theoretical basis and experimental evidence for applying G. pentaphyllum to treating hyperlipidemia.
Later Life Food Insecurity and Social Isolation in Ghana: The Importance of Psychological Factors
Authors: Gyasi Razak M. , Phillips David R. , Aikins Emelia , Peltzer Karl , Accam Burnett Tetteh , Frempong Foster , Dwumah Peter , Koomson‐Yalley Elizabeth Nana Mbrah , Asiedu Hubert Bimpeh , Abass Kabila , Hajek André 
Published: August 2024

ABSTRACTBackgroundSocial isolation (SI) and food insecurity (FI) are important social determinants of health that can negatively impact well‐being in old age. While research on the association between FI and SI is limited in LMICs, the mediators of this association are largely unknown. This cross‐sectional study examined whether FI is associated with SI among older adults in Ghana and whether psychological factors (i.e., depression, anxiety, and sleep problems) mediated the association.MethodsOur study consisted of adults aged ≥50 years in the Aging, Health, Well‐being, and Health‐seeking Behavior Study. SI was assessed with the Berkman‐Syme Social Network Index, while FI was assessed with dietary inadequacy‐related items. We used an ordinary least squares regression (OLS), logistic regressions, and bootstrapping modeling approach to examine our hypotheses with p < 0.05.ResultsThe analysis included 1201 individuals (Mage = 66 [SD = 12], women = 63%). In the full sample (β = 0.21; p < 0.001) and in women (β = 0.30, p < 0.001) but not in men, FI was independently associated with SI. FI was comparably associated with increases in SI for the 50–64 age group (β = 0.21, p < 0.001) and ≥65 age cohort (β = 0.19, p < 0.01). Moreover, FI showed differential associations with specific domains of SI (OR = 1.81 to 1.45, p < 0.001). Finally, the FI‐SI association was mediated by depressive symptoms (65.16%), anxiety symptoms (30.16%), and sleep problems (9.50%).ConclusionsOur data highlight the fundamental role of FI in SI among older adults, and the effect is explained by psychosocial factors. Interventions targeted toward strengthening interpersonal ties in old age should include addressing FI and older adults' psychosocial outcomes.