bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategizing and organizing in the innovation process
Authors: Gandia Romain , Tourancheau Florence 
Published: May 2015

Purpose– This paper aims to analyze the strategizing and organizing practices in the innovation process by using a processual approach. Three types of practices are examined: discursive, episodic and administrative. Their arrangement and their influence are also studied in the innovation process. The final objective is to understand the making process of the strategizing/organizing (S/O) duality, which remains today one of the major challenges of the strategy-as-practice.Design/methodology/approach– The paper uses a longitudinal and qualitative methodology applied to a single case study. Primary data are based on 18 semi-directive interviews during a three-year period. Secondary data came from various meeting and reports, Web sites, newspapers and newsletters.Findings– The results show that strategizing and organizing practices are preconditioned by the phases of the innovation process. In the idea generation, commercialization and diffusion phases, strategizing takes precedence over the organizing, whereas in the R & D phase, it is the opposite. In the industrialization phase, strategizing and organizing are carried out simultaneously. Other results highlight the influence between discursive, episodic and administrative practices in the innovation process.Practical implications– This research offers guidance to practitioners of innovation who want to attain a deeper understanding of the innovation-making process and its close ties with strategizing and organizing.Originality/value– The authors empirically validate the making process of the S/O duality and examine the theoretical and empirical relevance of an innovizing concept, when the innovation-making process implicitly generates the production of a new inseparable S/O duality.
Overconfidence of vocational education students when entering higher education
Authors: Bowden Mark P. , Abhayawansa Subhash , Bahtsevanoglou John 
Published: May 2015

Purpose
– There is evidence that students who attend Technical and Further Education (TAFE) prior to entering higher education underperform in their first year of study. The purpose of this paper is to examine the role of self-efficacy in understanding the performance of students who completed TAFE in the previous year in a first year subject of microeconomics in a dual sector university in Melbourne, Australia.

Design/methodology/approach
– The study utilises data collected by surveys of 151 students.

Findings
– A student’s self-efficacy is positively associated with their marks in a first year subject of microeconomics. However, the relationship between final marks and self-efficacy is negative for those students who attended TAFE in the previous year suggesting that they suffer from the problem of overconfidence. When holding self-efficacy constant, using econometric techniques, TAFE attendance is found to be positively related to final marks.

Research limitations/implications
– The findings are exploratory (based on a small sample) and lead to a need to conduct cross institutional studies.

Practical implications
– The research points to the need for early interventions so that TAFE students perform well in their first year of higher education. It also points to potential issues in the development of Victorian Certificate of Applied Learning (VCAL) programs.

Originality/value
– To the best of the authors’ knowledge, this is the first paper to examine the inter-related impact of attendance at TAFE in the previous year and self-efficacy on the subsequent academic performance of TAFE students.
Vitamin D3 levels and bone mineral density in patients with psoriasis and/or psoriatic arthritis
Authors: Kincse Gyöngyvér , Bhattoa Pál Harjit , Herédi Emese , Varga József , Szegedi Andrea , Kéri Judit , Gaál János 
Published: May 2015

AbstractLimited data are available on the vitamin D3 status and bone mineral density (BMD) of patients with psoriasis or with psoriatic arthritis. Our study intended to explore possible correlations between vitamin D status and BMD, as well as among these parameters and the features of the underlying disorder. Seventy‐two patients with psoriasis/or psoriatic arthritis (female : male ratio, 40:32; mean age, 58.5 ± 11.6 years; mean duration of follow up, 142.7 ± 147.7 months) participated in the study. We evaluated the characteristic clinical features of the underlying disease, performed bone densitometry of the lumbar spine and the hip region, measured the serum vitamin 25(OH)D3 levels of the patients, and undertook the statistical analysis of the relationships between the clinical and the laboratory parameters. The proportion of patients with a low BMD value did not exceed that seen in the general population. We found an inverse correlation between the serum level of vitamin 25(OH)D3 and body mass index, as well as between the former and the severity of skin involvement. Furthermore, the activity of psoriatic arthritis was significantly higher in patients with inadequate vitamin D3 status. In patients with psoriatic arthritis, BMD significantly exceeded the values measured in patients suffering from psoriatic skin lesions only. Our findings suggest the importance of evaluating the vitamin D3 status and screening for comorbid conditions in patients with psoriasis or psoriatic arthritis. This appears justified, in particular, due to the possible role of hypovitaminosis D3 in provoking the development of skin lesions and joint symptoms.
Familial Mediterranean fever variant with repeated atypical skin eruptions
Authors: Takahashi Tomoko , Fujisawa Tomomi , Kimura Masaki , Ohnishi Hidenori , Seishima Mariko 
Published: May 2015

AbstractFamilial Mediterranean fever (FMF) is characterized by self‐limited bouts of fever and polyserositis. Skin involvement is not common in FMF, and erysipelas‐like erythema is found to be the most frequent skin eruption which is often accompanied by arthritis and fever, and disappears within 12–72 h. We report a 40‐year‐old Japanese woman who presented with a 2‐year history of recurrent fever with general fatigue, polyarthralgia and transient maculopapular eruptions on her lower extremities and trunk. The histological findings of the maculopapular eruption showed lymphocyte infiltration around the capillaries in the entire dermis. Mutation analysis showed a heterozygous E148Q‐P369S mutation of MEFV. These findings suggested a diagnosis of late‐onset FMF variant with atypical skin eruptions. The patient was successfully treated with colchicine. Thus, we should pay attention to repeated atypical skin eruptions for the early detection of atypical FMF.
Three‐dimensional focused seismic imaging for geothermal exploration in crystalline rock near Schneeberg, Germany
Authors: Hloušek Felix , Hellwig Olaf , Buske Stefan 
Published: May 2015

ABSTRACTWe present the results of a 3D seismic survey acquired near the city of Schneeberg in the western Erzgebirge (Germany). The main objective of this survey was to use reflection seismic exploration methods to image a major fault zone in crystalline rock, which could serve as a geothermal reservoir at a target depth of about 5 km–6 km with expected temperatures between 160°C–180°C. For this purpose, a high‐resolution 3D Vibroseis survey was performed in late 2012 covering an area of about 10 km × 12 km. The 3D survey was complemented by a wide‐angle seismic survey for obtaining velocity information from greater depths using explosives along ten profile lines radially centred at the target area. The region itself is dominated by the northwest‐southeast striking Gera‐Jáchymov fault system and the southwest–northeast striking Lössnitz–Zwönitz syncline. The main geological features in the survey area are well known from intensive mining activities down to a depth of about 2 km. The seismic investigations aimed at imaging the partly steeply dipping fault branches at greater depths, in particular a dominant steeply northeast dipping fault (Roter Kamm) in the central part of the survey area. In addition to this main structure, the Gera–Jáchymov fault zone consists of a series of steeply southwest dipping conjugate faults. For imaging these structures, we used a focusing pre‐stack depth migration technique, where the wavefield coherency at neighbouring receivers is used for weighting the amplitudes during migration. This method delivers a clear, focused image of the 3D structures within the target area. A 3D velocity model for depth imaging was obtained by first‐arrival tomography of the wide‐angle survey data. With this approach, we were able to image several pronounced structures interpreted as faults within the crystalline rock units, which partly reach the target depth where the temperatures for a geothermal usage would be sufficient. In general, the results show a complex three‐dimensional image of the geological structures with different reflection characteristics, which can serve as a basis for a detailed characterization of the potential deep geothermal reservoir.
Co‐administration of deflazacort and doxycycline: a potential pharmacotherapy for Duchenne muscular dystrophy
Authors: Pereira Juliano Alves , Marques Maria Julia , Santo Neto Humberto 
Published: May 2015

SummaryThe standard therapy used in the treatment of Duchenne muscle dystrophy (DMD) is corticoids, such as deflazacort and prednisone. However, they have limited therapeutic value, and their combination with drugs already in use to treat other human diseases could potentially increase corticoid outcomes in DMD. In the present study, we evaluated whether a combined therapy of the corticoid deflazacort with doxycycline could result in greater improvement in mdx dystrophy than deflazacort alone. Deflazacort alone or deflazacort/doxycycline were administered for 36 days (starting on postnatal day 0) in drinking water. Histopathological, biochemical (creatine kinase), functional (forelimb muscle grip strength and fatigue) parameters and inflammatory markers (MMP‐9, TNF‐α, NF‐kB) were evaluated in biceps brachii and diaphragm muscles of the mdx mice. The combined therapy was superior in improving the dystrophic phenotype compared to monotherapy. The primary results were observed in attenuating muscle fatigue, decreasing muscle total calcium and inflammatory markers and increasing β‐dystroglycan, a main component of the dystrophin‐protein complex. Furthermore, the combined therapy was effective in preventing the loss of body mass observed with deflazacort alone at this very early stage of therapy. The present study offers preclinical data to support further studies with deflazacort/doxycycline combined therapy in DMD clinical trials.
SLE myopathy: a clinicopathological study
Authors: Jakati Saumya , Rajasekhar Liza , Uppin Megha , Challa Sundaram 
Published: May 2015

AbstractAimTo study the histological changes in muscle biopsy in patients diagnosed with systemic lupus erythematosus (SLE) and presenting with muscle symptoms.Materials and MethodsPatients with SLE presenting with muscle symptoms at presentation or during follow‐up and treatment between January 2010 and May 2014 and who underwent muscle biopsy were included in the study. Demographic, clinical features, serological markers, and Electromyoneurography findings were collected. Muscle biopsies were evaluated for inflammation, fiber type abnormalities, vasculitis and interstitial changes according to 2004 European Neuromuscular Centre criteria.ResultsFifteen patients underwent muscle biopsy in the study period. Clinical presentations included mucocutaneous (9), musculoskeletal (14), hematological (3), renal (8), hepatic (1) and central nervous system (CNS) (4) manifestations, and neuropathy (4), serositis (2), Raynaud's phenomenon (1) and infectious complications (8). Histological findings were perivascular/perimysial inflammation (7/15), type 1 predominance (7/15) and type 2 atrophy (13/15). Clinical evidence of myositis was seen in 8.8% of patients in the SLE registry, whereas histological evidence of myositis was seen in 46.66% of biopsied patients with muscle symptoms. There was no significant difference in clinical, serological, laboratory and muscle histology features between groups of patients with or without myositis. Type 2 atrophy was the predominant finding in SLE patients irrespective of time of muscle biopsy, treatment received and presence or absence of myositis.ConclusionsHistological evidence of myositis was found in 46.66% of SLE patients and there were no significant differences in clinical/laboratory features in patients with or without myositis. Type 2 atrophy was seen in patients irrespective of time of the biopsy, treatment received and presence or absence of myositis. Type 2 atrophy was considered the major cause for muscle symptoms.
Global statistics on addictive behaviours: 2014 status report
Authors: Gowing Linda R. , Ali Robert L. , Allsop Steve , Marsden John , Turf Elizabeth E. , West Robert , Witton John 
Published: May 2015

AbstractBackground and aimsAddictive behaviours are among the greatest scourges on humankind. It is important to estimate the extent of the problem globally and in different geographical regions. Such estimates are available, but there is a need to collate and evaluate these to arrive at the best available synthetic figures. Addiction has commissioned this paper as the first of a series attempting to do this.MethodsOnline sources of global, regional and national information on prevalence and major harms relating to alcohol use, tobacco use, unsanctioned psychoactive drug use and gambling were identified through expert review and assessed. The primary data sources located were the websites of the World Health Organization (WHO), the United Nations Office on Drugs and Crime (UNODC) and the Alberta Gambling Research Institute. Summary statistics were compared with recent publications on the global epidemiology of addictive behaviours.ResultsAn estimated 4.9% of the world's adult population (240 million people) suffer from alcohol use disorder (7.8% of men and 1.5% of women), with alcohol causing an estimated 257 disability‐adjusted life years lost per 100 000 population. An estimated 22.5% of adults in the world (1 billion people) smoke tobacco products (32.0% of men and 7.0% of women). It is estimated that 11% of deaths in males and 6% of deaths in females each year are due to tobacco. Of ‘unsanctioned psychoactive drugs’, cannabis is the most prevalent at 3.5% globally, with each of the others at < 1%; 0.3% of the world's adult population (15 million people) inject drugs. Use of unsanctioned psychoactive drugs accounts for an estimated 83 disability‐adjusted life years lost per 100 000 population. Global estimates of problem gambling are not possible, but in countries where it has been assessed the prevalence is estimated at 1.5%.ConclusionsTobacco and alcohol use are by far the most prevalent addictive behaviours and cause the large majority of the harm. However, the quality of data on prevalence and addiction‐related harms is mostly low, and comparisons between countries and regions must be viewed with caution. There is an urgent need to review the quality of data on which global estimates are made and coordinate efforts to arrive at a more consistent approach.
SVSI: Fast and Powerful Set‐Valued System Identification Approach to Identifying Rare Variants in Sequencing Studies for Ordered Categorical Traits
Authors: Bi Wenjian , Kang Guolian , Zhao Yanlong , Cui Yuehua , Yan Song , Li Yun , Cheng Cheng , Pounds Stanley B. , Borowitz Michael J. , Relling Mary V. , Yang Jun J. , Liu Zhifa , Pui Ching‐Hon , Hunger Stephen P. , Hartford Christine M. , Leung Wing , Zhang Ji‐Feng 
Published: May 2015

SummaryIn genetic association studies of an ordered categorical phenotype, it is usual to either regroup multiple categories of the phenotype into two categories and then apply the logistic regression(LG), or apply ordered logistic(oLG), or ordered probit(oPRB)regression, which accounts for the ordinal nature of the phenotype. However, they may lose statistical power or may not control type I error due to their model assumption and/or instable parameter estimation algorithm when the genetic variant is rare or sample size is limited. To solve this problem, we propose a set‐valued(SV)system model to identify genetic variants associated with an ordinal categorical phenotype. We couple this model with a SV system identification algorithm to identify all the key system parameters. Simulations and two real data analyses show thatSVandLGaccurately controlled the Type I error rate even at a significance level of 10−6but notoLGandoPRBin some cases.LGhad significantly less power than the other three methods due to disregarding of the ordinal nature of the phenotype, andSVhad similar or greater power thanoLGandoPRB. We argue thatSVshould be employed in genetic association studies for ordered categorical phenotype.
Influence of less than full‐time or full‐time on totality of training and subsequent consultant appointment in anaesthesia
Authors: Randive S. , Johnston C. L. , Fowler A. M. , Evans C. S. 
Published: May 2015

SummaryChanges in medical training have increased the popularity of less than full‐time training. However, there are no data on the impact on training time or consultant workforce. We reviewed a three‐year cohort of trainees via the Royal College of Anaesthetist's training and recruitment databases. Eighty‐eight (96%) less than full‐time trainees and 677 (95%) full‐time trainees were appointed to a substantive consultant post (p = 0.82). Three (3%) less than full‐time trainees and 12 (2%) full‐time trainees gained part‐time consultant posts (p < 0.001). Average length of training (years, months, days) was 8 y, 5 m, 6 d (median (IQR [range]) 5 y, 0 m, 14 d (4 y, 11 m, 29 d – 9 y, 8 m, 3 d [4 y, 2 m, 18 d – 12 y, 0 m, 0 d]) for full‐time and 10 y, 8 m, 23 d (median (IQR [range]) 7 y, 3 m, 28 d (6 y, 7 m, 24 d – 11 y, 1 m, 23 d [4 y, 11 m, 29 d – 11 y, 9 m, 10 d]) for less than full‐time trainees. The average length of training for both groups is significantly longer than the seven years used in workforce planning.
In patients with myelodysplastic syndromes with del(5q), factors other than age and sex contribute to the prognostic advantage, which diminishes over time
Authors: Lauseker Michael , Schemenau Jennifer , Strupp Corinna , Kündgen Andrea , Gattermann Norbert , Hasford Joerg , Germing Ulrich 
Published: May 2015

SummaryThis study aimed to determine the extent to which the prognostic advantage of myelodysplastic syndromes (MDS) with del(5q) is due to the more favourable age and sex distribution of patients in that group when compared to other MDS subtypes. A total of 1912 MDS patients from the Duesseldorf registry with less than 5% blasts in the bone marrow were evaluable and had complete covariates. As endpoints, overall survival and progression to acute myeloid leukaemia (AML) were considered. Cox models were computed for both outcomes. A multivariate Cox model for survival confirmed higher age and male sex as risk factors. In addition, we found a survival advantage of 9·1 years for MDS del(5q) patients compared to refractory cytopenia with unilineage dysplasia, while the survival advantage of MDS del(5q) over refractory cytopenia with multilineage dysplasia was 18·6 years. Considering progression to AML, we did not find any significant differences between the World Health Organization classification subtypes. Our analyses show that the higher survival probabilities of MDS del(5q) patients are not only due to age and sex, although higher age and male sex were also important risk factors. Interestingly, it seems that the survival advantage of MDS del(5q) decreases over time.
A meta‐analysis of mammographic screening with and without clinical breast examination
Authors: Hamashima Chisato , Ohta Koji , Kasahara Yoshio , Katayama Takafumi , Nakayama Tomio , Honjo Satoshi , Ohnuki Koji 
Published: May 2015

Mammographic screening with clinical breast examination has been recommended in Japan since 2000. Although mammographic screening without clinical breast examination has not been recommended, its introduction is anticipated. The efficacies of mammographic screening with and without clinical breast examination were evaluated based on the results of randomized controlled trials. PubMed and other databases for studies published between 1985 and 2014 were searched. The study design was limited to randomized controlled trials to evaluate mortality reduction from breast cancer. Five studies were eligible for meta‐analysis of mammographic screening without clinical breast examination. The relative risk for women aged 40–74 years was 0.75 (95% confidence interval, 0.67–0.83). Three studies evaluated the efficacy of mammographic screening with clinical breast examination. The relative risk for women aged 40–64 years was 0.87 (95% confidence interval, 0.77–0.98). The number needed to invite was always lower in mammographic screening without clinical breast examination than in mammographic screening with clinical breast examination. In both screening methods, the number needed to invite was higher in women aged 40–49 years than in women aged 50–70 years. These results suggest that mammographic screening without clinical breast examination can afford higher benefits to women aged 50 years and over. Although evidence of the efficacy of mammographic screening without clinical breast examination was confirmed based on the results of the randomized controlled trials, a Japanese study is needed to resolve local problems.
Real-time quantitative reverse transcription–polymerase chain reaction to detect propionibacterial ribosomal RNA in the lymph nodes of Chinese patients with sarcoidosis
Authors: Zhou Y , Wei Y-R , Zhang Y , Du S-S , Baughman R P , Li H-P 
Published: May 2015

Summary
The aim of this study was to investigate the diagnostic value of using the copy number of propionibacterial rRNA as a biomarker for sarcoidosis. Ribosomal RNA of Propionibacterium acnes and P. granulosum was measured by real-time quantitative reverse transcription–polymerase chain reaction (RT–PCR) using formalin-fixed and paraffin-embedded tissue of lymph node biopsy from 65 Chinese patients with sarcoidosis, 45 with tuberculosis and 50 controls with other diseases (23 with non-specific lymphadenitis and 27 with mediastinal lymph node metastasis from lung cancer). The receiver operating characteristic (ROC) curve was analysed to determine an optimal cut-off value for diagnosis, and the diagnostic accuracy of the cut-off value was evaluated in additional tissue samples [24 patients with sarcoidosis and 22 with tuberculosis (TB)]. P. acnes or P. granulosum rRNA was detected in 48 of the 65 sarcoidosis samples but only in four of the 45 TB samples and three of the 50 control samples. Analysis of the ROC curve revealed that an optimal cut-off value of the copy number of propionibacterial rRNA for diagnosis of sarcoidosis was 50·5 copies/ml with a sensitivity and specificity of 73·8 and 92·6%, respectively. Based on the cut-off value, 19 of the 24 additional sarcoidosis samples exhibited positive P. acnes or P. granulosum, whereas only one of the 22 additional TB samples was positive, resulting in a sensitivity and specificity of 79·2 and 95·5%, respectively. These findings suggest that propionibacteria might be associated with sarcoidosis granulomatous inflammation. Detection of propionibacterial rRNA by RT–PCR might possibly distinguish sarcoidosis from TB.