bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound Examination for Infants Born Breech by Elective Cesarean Section With a Normal Hip Exam for Instability
Authors: Pacana Matthew J. , Hennrikus William L. , Slough Jennifer , Curtin William 
Published: October 2015

Introduction:
Because of the risk of developmental dysplasia of the hip in infants born breech—despite a normal physical exam—the American Academy of Pediatrics (AAP) guidelines recommend ultrasound (US) hip imaging at 6 weeks of age for breech females and optional imaging for breech males. The purpose of this study is to report US results and follow-up of infants born breech with a normal physical exam.

Methods:
The electronic medical record for children born at 1 hospital from 2008 to 2011 was reviewed. Data were analyzed for sex, birth weight, breech position, birth order, ethnicity, US and x-ray results, follow-up, and cost.

Results:
A total of 237 infants were born breech with a normal physical examination, all delivered by cesarean section. Of the infants, 55% were male and 45% female. About 151 breech infants (64%) with a normal Barlow and Ortolani exam had a precautionary hip US as recommended by the AAP performed at an average of 7 weeks of age. Eighty-six breech infants (35%) did not have an US and were followed clinically. Of the 151 infants that had an US, 140 (93%) were read as normal. None had a dislocated hip. Two patients had a normal physical exam but laxity on US. These 2 patients were the only infants treated in a Pavlik harness. A pediatric orthopaedic surgeon followed those with subtle US findings and no laxity until normal.

Conclusions:
The decision by the AAP to recommend US screening at 6 weeks of age for infants with a normal physical exam but breech position was based on an extensive literature review and expert opinion. Not all pediatricians are following the AAP guidelines. The decision to perform an US should be done on a case-by-case basis by the examining physician. A more practical, cost-effective strategy would be to skip the US if the physical exam is normal and simply obtain an AP pelvis x-ray at 4 months.

Level of Evidence:
Level III—this is a case-control study investigating the outcomes of infants on data drawn from the electronic medical record.
Long-term Outcome of External Tibial Derotation Osteotomies in Children With Cerebral Palsy
Authors: Er Mehmet S. , Bayhan Ilhan A. , Rogers Kenneth J. , Abousamra Oussama , Church Chris , Henley John , Miller Freeman 
Published: October 2015

Background:
Internal tibial torsion (ITT) is a common boney deformity in children with cerebral palsy (CP). The current recommended treatment is tibial derotation osteotomy (TDO) to improve gait biomechanics. Satisfactory short-term results after TDO have been reported but long-term results have not been studied. The purpose of this study was to evaluate the long-term outcome after external TDO performed to correct ITT in ambulatory children with CP.

Methods:
Following IRB approval, gait kinematics and passive range of motion measurements were retrospectively evaluated in children with spastic CP who underwent TDO due to ITT comparing preoperative (E0), short-term postoperative (E1; 1 to 3 y post), and long-term postoperative (E2; >5 y post) results. Limbs were categorized as corrected, undercorrected, or overcorrected at both E1 and E2, by comparing the subjects mean tibial rotation (MTR) in gait to a group of typically developing children. Age at surgery, preop MTR (at E0), preop gait velocity (at E0), gross motor function classification system score, and foot deformity were evaluated to determine their influence on long-term results.

Results:
The study sample consisted of 36 legs (with E0 and E2) and 17 legs (with E0, E1, and E2). The mean age at surgery was 7.4±2.8 (range, 4 to 16.6) years. Comparing the changes over time, kinematic MTR improved from 17±11 degrees initially (E0) to −10±14 degrees short term (E1) and progressed to −23±13 degrees long term (E2) (P<0.05 E0/E1/E2; internal rotation is positive). At E2, 16 legs (44%) were found to be in the kinematic corrected group and 20 legs (56%) in the kinematic overcorrected group. There were no significant differences between the corrected and overcorrected groups of children in respect to age of surgery, gross motor function classification system, E0 MTR, gait velocity, or foot deformity.

Conclusions:
Although external TDO is an accepted form of treatment in children with CP, in the long term a tendency to move into external tibial torsion is common. Therefore, caution is warranted with children who initially present with ITT to avoid overcorrection.

Level of Evidence:
Level IV—therapeutic study.
Preoperative Computer Simulation and Patient-specific Guides are Safe and Effective to Correct Forearm Deformity in Children
Authors: Bauer Andrea S. , Storelli Dora A. R. , Sibbel Sarah E. , McCarroll H. Relton , Lattanza Lisa L. 
Published: October 2015

Background:
Posttraumatic and congenital forearm deformities in children can be difficult to appreciate in all planes. In cases of distal radioulnar joint instability and loss of forearm rotation, surgical correction is challenging. Advances in 3-dimensional printing allow creation of custom guides at a reasonable cost, enabling precise correction of the deformity in all planes.

Methods:
Nineteen children with deformity of the forearm had corrective osteotomies performed using preoperative 3-dimensional computer modeling and patient-specific surgical guides. Surgicase software was used for 3-dimensional planning of the corrective osteotomy, by superimposing a mirror image of the unaffected side as a template. Based upon this planning, patient-specific surgical guides were manufactured. Radiographic and clinical outcomes were assessed.

Results:
Three patients had a diagnosis of multiple hereditary exostoses, and one of Madelung’s deformity. The remaining 15 patients had a diagnosis of fracture malunion. Average preoperative angulation of both the radius and ulna was 23 degrees. For the patients with fracture malunions, the time from injury to surgery ranged from 6 months to 8 years. Twelve patients underwent osteotomies of both the radius and ulna, 5 had osteotomies of the radius alone, and 2 had a single osteotomy of the ulna only. All osteotomies went on to unite and no patient lost range of motion. Preoperative arc of forearm rotation averaged 101 degrees (range 0 to 180 degrees). Postoperatively, this improved to 133 degrees (range 85 to 180 degrees). Eight patients had distal radioulnar instability preoperatively, all of which normalized after surgery. There were 4 complications: 1 hypertrophic scar, 1 subject with extensor pollicis longus weakness, and 2 transient sensory losses in the superficial radial nerve distribution.

Conclusions:
This case series demonstrates that 3-dimensional computer modeling permits complex and multiple osteotomies to be done safely to achieve deformity correction in children. Limitations in forearm rotation and distal radioulnar malalignment can be reliably improved using this technique.

Level of Evidence:
Level IV—retrospective case series.
Predictors of Recurrent Patellar Instability in Children and Adolescents After First-time Dislocation
Authors: Jaquith Bradley P. , Parikh Shital N. 
Published: October 2015

Background:
Patellar dislocations are one of the most common knee injuries in children and adolescents and are challenging to treat. Recurrence rates are relatively high and many patients have functional limitations, even in the absence of a recurrent instability episode. The purpose of this study was to examine the risk factors in patients with first-time patellofemoral dislocations to develop a prediction model of recurrence.

Methods:
A single institution retrospective review of all patients with a first-time patellofemoral dislocation from 2002 to 2013 was performed. Demographic risk factors (age, sex, laterality, mechanism of injury, and history of contralateral patellar dislocation) and radiographic risk factors (increased patella height, trochlear dysplasia, and skeletal immaturity) were examined. Patella height was measured using Caton-Deschamps index (CDI). Trochlear dysplasia was assessed using the 2-grade Dejour classification and skeletal immaturity was assessed based on the distal femur and proximal tibia physis (open, closing, or closed).

Results:
In total, 266 knees in 250 patients were included in the study. Of these, 222 (83.5%) were treated nonoperatively and 44 (16.5%) were treated surgically. Of the knees treated nonoperatively, 77 (34.7%) had a recurrence. Significant risk factors for recurrence on univariate analysis were age 14 years and below, history of contralateral patellar dislocation, trochlear dysplasia, skeletal immaturity, and a CDI>1.45. Multivariate analysis was performed and trochlear dysplasia and skeletal immaturity were the most significant factors with odds ratios of 3.56 and 2.23, respectively. The presence of all 4 multivariate risk factors (CDI>1.45, history of contralateral patellar dislocation, trochlear dysplasia, and skeletal immaturity) had a predicted risk of recurrence of 88%. The presence of any 3 risk factors had a predicted risk of about 75% and the presence of any 2 risk factors had a predicted risk of about 55%.

Conclusions:
Trochlear dysplasia, skeletal immaturity, CDI>1.45, and a history of contralateral patellar dislocation were all significant risk factors for recurrence in patients with first-time patellar dislocations. A predictive model for calculation of recurrence risk was developed for any combination of the different risk factors. This information is useful when counseling patients and their families after first-time patellar dislocation about prognosis and potential outcomes.

Level of Evidence:
Level IV—retrospective case series.
Efficient genome-wide sequencing and low coverage pedigree analysis from non-invasively collected samples
Authors: Snyder-Mackler Noah , Majoros William H. , Yuan Michael L. , Shaver Amanda O. , Gordon Jacob B. , Kopp Gisela H. , Schlebusch Stephen A. , Wall Jeffrey D. , Alberts Susan C. , Mukherjee Sayan , Zhou Xiang , Tung Jenny 
Published: October 2015

ABSTRACTResearch on the genetics of natural populations was revolutionized in the 1990’s by methods for genotyping non-invasively collected samples. However, these methods have remained largely unchanged for the past 20 years and lag far behind the genomics era. To close this gap, here we report an optimized laboratory protocol for genome-wide capture of endogenous DNA from non-invasively collected samples, coupled with a novel computational approach to reconstruct pedigree links from the resulting low-coverage data. We validated both methods using fecal samples from 62 wild baboons, including 48 from an independently constructed extended pedigree. We enriched fecal-derived DNA samples up to 40-fold for endogenous baboon DNA, and reconstructed near-perfect pedigree relationships even with extremely low-coverage sequencing. We anticipate that these methods will be broadly applicable to the many research systems for which only non-invasive samples are available. The lab protocol and software (“WHODAD”) are freely available atwww.tung-lab.org/protocolsandwww.xzlab.org/software, respectively.
Robust and Stable Gene Selection via Maximum-Minimum Correntropy Criterion
Authors: Mohammadi Majid , Sharifi Noghabi Hossein , Hodtani Ghosheh Abed , Rajabi Mashhadi Habib 
Published: October 2015

AbstractOne of the central challenges in cancer research is identifying significant genes among thousands of others on a microarray. Since preventing outbreak and progression of cancer is the ultimate goal in bioinformatics and computational biology, detection of genes that are most involved is vital and crucial. In this article, we propose a Maximum-Minimum Correntropy Criterion (MMCC) approach for selection of biologically meaningful genes from microarray data sets which is stable, fast and robust against diverse noise and outliers and competitively accurate in comparison with other algorithms. Moreover, via an evolutionary optimization process, the optimal number of features for each data set is determined. Through broad experimental evaluation, MMCC is proved to be significantly better compared to other well-known gene selection algorithms for 25 commonly used microarray data sets. Surprisingly, high accuracy in classification by Support Vector Machine (SVM) is achieved by less than10 genes selected by MMCC in all of the cases.
A scalable permutation approach reveals replication and preservation patterns of gene coexpression modules
Authors: Ritchie Scott C. , Fearnley Liam G. , Abraham Gad , Inouye Michael 
Published: October 2015

AbstractGene coexpression network modules provide a framework for identifying shared biological functions. Analysis of topological preservation of modules across datasets is important for assessing reproducibility, and can reveal common function between tissues, cell types, and species. Although module preservation statistics have been developed, heuristics have been required for significance testing. However, the scale of current and future analyses requires accurate and unbiased p-values, particularly to address the challenge of multiple testing. Here, we developed a rapid and efficient approach (NetRep) for assessing module preservation and show that module preservation statistics are typically non-normal, necessitating a permutation approach. Quantification of module preservation across brain, liver, adipose, and muscle tissues in a BxH mouse cross revealed complex patterns of multi-tissue preservation with 52% of modules showing unambiguous preservation in one or more tissues and 25% showing preservation in all four tissues. Phenotype association analysis uncovered a liver-derived gene module which harboured housekeeping genes and which also displayed adipose and muscle tissue specific association with body weight. Taken together, our study presents a rapid unbiased approach for testing preservation of gene network topology, thus enabling rigorous assessment of potentially conserved function and phenotype association analysis.
Variation in linked selection and recombination drive genomic divergence during allopatric speciation of European and American aspens
Authors: Wang Jing , Street Nathaniel R. , Scofield Douglas G. , Ingvarsson Pär K. 
Published: October 2015

AbstractDespite the global economic and ecological importance of forest trees, the genomic basis of differential adaptation and speciation in tree species is still poorly understood.Populus tremulaandP. tremuloidesare two of the most widespread tree species in the Northern Hemisphere. Using whole-genome re-sequencing data of 24P. tremulaand 22P. tremuloidesindividuals, we find that the two species diverged ∼2.2-3.1 million years ago, coinciding with the severing of the Bering land bridge and the onset of dramatic climatic oscillations during the Pleistocene. Both species have experienced substantial population expansions following long-term declines after species divergence. We detect widespread and heterogeneous genomic differentiation between species, and in accordance with the expectation of allopatric speciation, coalescent simulations suggest that neutral evolutionary processes can account for most of the observed patterns of genomic differentiation. However, there is an excess of regions exhibiting extreme differentiation relative to those expected under demographic simulations, which is indicative of the action of natural selection. Overall genetic differentiation is negatively associated with recombination rate in both species, providing strong support for a role of linked selection in generating the heterogeneous genomic landscape of differentiation between species. Finally, we identify a number of candidate regions and genes that may have been subject to positive and/or balancing selection during the speciation process.
Auto-body assembly process fault diagnosis based on a dynamic variation modeling approach
Authors: Liu Yinhua , Ye Xialiang , Ji Feixiang , Jin Sun 
Published: October 2015

Purpose
– This paper aims to provide a new dynamic modeling approach for root cause detection of the auto-body assembly variation.

Design/methodology/approach
– The dynamic characteristics, such as fixture element wear and quality of incoming parts, are considered in assembly variation modeling with the dynamic Bayesian network. Based on the network structure mapping, the parameter learning of different types of nodes is conducted by integrating process knowledge and Monte Carlo simulation. The inference was that both the measurement data and maintenance actions are evidence for the improvement of diagnosis accuracy.

Findings
– The proposed assembly variation model which has incorporated dynamic manufacturing features could be used to detect multiple process faults effectively.

Originality/value
– A dynamic variation modeling method is proposed. This method could be used to provide more accurate diagnosis results and preventive maintenance guidelines for the assembly process.
Proximity query based on second order cone programming using convex superquadrics: a static collision detection algorithm for narrow-phase
Authors: Chen Lin , Ni Chongqi , Feng Junjie , Dai Jun , Huang Bingqiong , Liu Huaping , Pan Haihong 
Published: October 2015

Purpose
– This paper aims to find an objects representation scheme with high precision and to compute the objects’ separation distance effectively in final analysis. Proximity queries have been used widely in robot trajectory planning, automatic assembly planning, virtual surgery and many other applications. The core of proximity query is the precise computation of (minimum) separation distance in narrow phase, and specific object representation scheme corresponds to different methods of separation distance computation.

Design/methodology/approach
– In this paper, a second-order cone programming (SOCP)-based (minimum) separation distance computation algorithm was proposed. It treats convex superquadrics, descriptive primitives of complex object as the study objects. The separation distance between two convex superquadrics was written as a general nonlinear programming (NLP) problem with superquadric constraints and then transformed into an SOCP problem with the method of conic formulation of superquadric constraints. Finally, a primal-dual interior point method embedded in MOSEK was used for solving the SOCP problem.

Findings
– The proposed algorithm achieved exact separation distance computation between convex superquadrics, with a relative error of 10-6. It is particularly suitable for proximity queries in narrow phase of static collision detection algorithms. Further, the proposed algorithm achieved continuous collision detection between rectilinear translation superquadrics.

Originality/value
– The proposed algorithm in narrow phase of static collision detection algorithms makes objects’ separation distance effectively computed. Proximity queries are easy and more accurate to perform in this way.
Improvement of location and orientation tolerances propagation control in cylindrical components assembly using stack-build assembly technique
Authors: Wang Lei , Sun Chuanzhi , Tan Jiubin , Zhao Bo , Wan Gu 
Published: October 2015

Purpose
– This paper aims to provide an assembly method to improve cylindrical components assembly quality. The proposed method not only could be applied to tolerance allocation, but also could guide the assembly of cylindrical components.

Design/methodology/approach
– The paper claims to provide a stack-build assembly method using a connective assembly model to take the location and orientation tolerances of a rotor stage into account. Through the separate analysis of the location and orientation tolerances propagation process in the assembly, the quality of the final assembly of the rotationally symmetric cylindrical components assembly could be improved by properly selecting component orientations to minimize the eccentric deviation in the assembly.

Findings
– The effectiveness of the proposed stack-build assembly technique in improving the tolerance propagation in the assembly of cylindrical components was verified through experiments run with a measuring machine. A real aero-engine rotor was assembly using the proposed method; compared to the direct-build assembly technique, which had the component orientations without consideration, the stack-build assembly technique could be used to reduce the eccentric deviation in cylindrical components assembly by nearly 50 per cent.

Originality/value
– Different with the old methods, the new method defined the tolerances in detail, such as perpendicularity and angle of the lowest point, and could guide the assembly by the features of surfaces on different components. Through measuring the special tolerances of surfaces on the components, the best assembly angle for each component could be obtained.
A zigzag path based joining method for fuselage panels in digital assembly
Authors: Wang Qing , Dou Yadong , Li Jiangxiong , Ke Yinglin 
Published: October 2015

Purpose
– The purpose of this paper is to design a reasonable joining path and achieve assembly automation for multiple arc-shaped panels. A fuselage panel is primarily composed of skins, stringers, frames and clips. Both inserted and nested structures are adopted in the panels to improve the strength and hermeticity of the fuselage. Due to the complex structures and relationships, it is a challenge to coordinate the arc-shaped panels in the assembly process.

Design/methodology/approach
– A motion sequence model which achieves arc approximation based on the relative motion of multiple panels is established. The initial position of the panels is obtained by decomposing the computer-aided design model of the panels. Two translation rules, i.e. progressively decreasing translation and limited deformation translation, are applied to determine the moving path of the panels. If a panel is not at its path node, a search algorithm is used to find the nearest path node. Finally, the key algorithms are implemented in an integration system to promote joining automation of multiple panels.

Findings
– The zigzag path is effective for the joining of multiple panels with complex mating relationships. The automation of the join–separate–rejoin operations is time-saving and safety-assuring. The proposed method is demonstrated in practical engineering and a good efficiency is obtained.

Practical implications
– This method has been used in a middle fuselage assembly project. The practical results show that the zigzag path is convenient to be stored and reused, and the synchronous movements of multiple curved panels are precisely realized. Additionally, the posture accuracy of panels is significantly improved, and the operating time is reduced considerably.

Originality/value
– This paper gives a solution including path planning and process integration to solve the joining problem of multiple panels. The research will promote the automation of fuselage assembly.