bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of gestational, placental and congenital malaria in north-west Colombia
Authors: Agudelo Olga , Arango Eliana , Maestre Amanda , Carmona-Fonseca Jaime 
Published: September 2013

AbstractBackgroundThe frequency of pregnancy-associated malaria is increasingly being documented in American countries. In Colombia, with higher frequency ofPlasmodium vivaxoverPlasmodium falciparuminfection, recent reports confirmed gestational malaria as a serious public health problem. Thick smear examination is the gold standard to diagnose malaria in endemic settings, but in recent years, molecular diagnostic methods have contributed to elucidate the dimension of the problem of gestational malaria. The study was aimed at exploring the prevalence of gestational, placental and congenital malaria in women who delivered at the local hospitals of north-west Colombia, between June 2008 and April 2011.MethodsA group of 129 parturient women was selected to explore the prevalence of gestational, placental and congenital malaria in a descriptive, prospective and transversal (prevalence) design. Diagnosis was based on the simultaneous application of two independent diagnostic tests: microscopy of thick blood smears and a polymerase chain reaction assay (PCR).ResultsThe prevalence of gestational malaria (thick smear /PCR) was 9.1%/14.0%; placental malaria was 3.3%/16.5% and congenital malaria was absent. A history of gestational malaria during the current pregnancy was significantly associated with gestational malaria at delivery.Plasmodium vivaxcaused 65% of cases of gestational malaria, whereasP. falciparumcaused most cases of placental malaria.ConclusionsGestational and placental malaria are a serious problem in the region, but the risk of congenital malaria is low. A history of malaria during pregnancy may be a practical indicator of infection at delivery.
Weight management interventions in adults with intellectual disabilities and obesity: a systematic review of the evidence
Authors: Spanos Dimitrios , Melville Craig Andrew , Hankey Catherine Ruth 
Published: September 2013

Abstract
To evaluate the clinical effectiveness of weight management interventions in adults with intellectual disabilities (ID) and obesity using recommendations from current clinical guidelines for the first line management of obesity in adults. Full papers on lifestyle modification interventions published between 1982 to 2011 were sought by searching the Medline, Embase, PsycINFO and CINAHL databases. Studies were evaluated based on 1) intervention components, 2) methodology, 3) attrition rate 4) reported weight loss and 5) duration of follow up. Twenty two studies met the inclusion criteria. The interventions were classified according to inclusion of the following components: behaviour change alone, behaviour change plus physical activity, dietary advice or physical activity alone, dietary plus physical activity advice and multi-component (all three components). The majority of the studies had the same methodological limitations: no sample size justification, small heterogeneous samples, no information on randomisation methodologies. Eight studies were classified as multi-component interventions, of which one study used a 600 kilocalorie (2510 kilojoule) daily energy deficit diet. Study durations were mostly below the duration recommended in clinical guidelines and varied widely. No study included an exercise program promoting 225–300 minutes or more of moderate intensity physical activity per week but the majority of the studies used the same behaviour change techniques. Three studies reported clinically significant weight loss (≥ 5%) at six months post intervention. Current data indicate weight management interventions in those with ID differ from recommended practice and further studies to examine the effectiveness of multi-component weight management interventions for adults with ID and obesity are justified.
Metastatic prostate cancer cell-specific phage-like particles as a targeted gene-delivery system
Authors: Fagbohun Olusegun A , Kazmierczak Robert A , Petrenko Valery A , Eisenstark Abraham 
Published: September 2013

AbstractBackgroundOne of the cardinal requirements for effective therapeutic management of tumors is the selective delivery of cancer drugs to the right site by ligand-decorated nanomedicines. Screening of 2 × 109clone landscape phage library provides a reliable avenue for generating protein ligands specific for tumor cells. It was shown that selective phage proteins derived from landscape phage libraries against breast and prostate cancer cells are able to navigate drug or siRNA loaded liposomes to corresponding cancer cells with minimal toxicity to non-neoplastic cells. In an alternative platform, glioma cell-specific phage proteins were used for assemblingin vivocancer-specific phage-like particles, named ‘phagemid infective particles’ as targeted gene-delivery vehicles.MethodsTo extend the panel of anticancer cell phages, we have screened a 2 × 109clone landscape phage library f8/8 to select phage clones specific for metastatic prostate cancer cell PC-3M. The phage clones were characterized for their selective interaction with PC-3M cells using phage capture assay, immunofluorescence microscopy and electron microscopy. A prostate cancer selective phage was converted to phage-like particles harboring emerald green fluorescent protein.ResultsPhage clone EPTHSWAT (designated by the sequence of inserted peptide) was found to be most selective for PC-3M cells and was observed to internalize PC-3M cells as revealed by immunofluorescence microscopy and electron microscopy. Conversion of this phage to phage-like particles harboring emerald green fluorescent protein and the expression of emerald green fluorescent protein in the phage-like particles treated PC-3M cells showed potential of adoption of this phage-like particle in prostate cancer therapeutic gene delivery.ConclusionSuccessful employment of phage-like particles expressing emerald green fluorescent protein genes targeted to prostate cancer cells PC-3M confirms a prospect of their use for targeted delivery of therapeutic genes to cancer cells.
Dynamics of bone healing after osteotomy with piezosurgery or conventional drilling– histomorphometrical, immunohistochemical, and molecular analysis
Authors: Esteves Jônatas Caldeira , Marcantonio Jr Elcio , de Souza Faloni Ana Paula , Rocha Fernanda Regina Godoy , Marcantonio Rosemary Adriana , Wilk Katarzyna , Intini Giuseppe 
Published: September 2013

Abstract

Background
Piezosurgery is an osteotomy system used in medical and dental surgery. Manystudies have proven clinical advantages of piezosurgery in terms of quality ofcut, maneuverability, ease of use, and safety. However, few investigations havetested its superiority over the traditional osteotomy systems in terms of dynamicsof bone healing. Therefore, the aim of this study was to evaluate the dynamics ofbone healing after osteotomies with piezosurgery and to compare them with thoseassociated to traditional bone drilling.

Methods
One hundred and ten rats were divided into two groups with 55 animals each. Theanimals were anesthetized and the tibiae were surgically exposed to create defects2 mm in diameter by using piezosurgery (Piezo group) and conventionaldrilling (Drill group). Animals were sacrificed at 3, 7, 14, 30 and 60 dayspost-surgery. Bone samples were collected and processed for histological,histomorphometrical, immunohistochemical, and molecular analysis. The histologicalanalysis was performed at all time points (n = 8) whereas thehistomorphometrical analysis was performed at 7, 14, 30 and 60 dayspost-surgery (n = 8). The immunolabeling was performed to detectVascular Endothelial Growth Factor (VEGF), Caspase-3 (CAS-3), Osteoprotegerin(OPG), Receptor Activator of Nuclear Factor kappa-B Ligand (RANKL), andOsteocalcin (OC) at 3, 7, and 14 days (n = 3). For the molecularanalysis, animals were sacrificed at 3, 7 and 14 days, total RNA wascollected, and quantification of the expression of 21 genes related to BMPsignaling, Wnt signaling, inflammation, osteogenenic and apoptotic pathways wasperformed by qRT-PCR (n = 5).

Results
Histologically and histomorphometrically, bone healing was similar in both groupswith the exception of a slightly higher amount of newly formed bone observed at30 days after piezosurgery (p < 0.05). Immunohistochemical andqRT-PCR analyses didn’t detect significant differences in expression of allthe proteins and most of the genes tested.

Conclusions
Based on the results of our study we conclude that in a rat tibial bone defectmodel the bone healing dynamics after piezosurgery are comparable to thoseobserved with conventional drilling.
HIV-1 envelope glycoprotein signatures that correlate with the development of cross-reactive neutralizing activity
Authors: van den Kerkhof Tom L G M , Feenstra K Anton , Euler Zelda , van Gils Marit J , Rijsdijk Linda W E , Boeser-Nunnink Brigitte D , Heringa Jaap , Schuitemaker Hanneke , Sanders Rogier W 
Published: September 2013

Abstract

Background
Current HIV-1 envelope glycoprotein (Env) vaccines are unable to induce cross-reactive neutralizing antibodies. However, such antibodies are elicited in 10-30% of HIV-1 infected individuals, but it is unknown why these antibodies are induced in some individuals and not in others. We hypothesized that the Envs of early HIV-1 variants in individuals who develop cross-reactive neutralizing activity (CrNA) might have unique characteristics that support the induction of CrNA.

Results
We retrospectively generated and analyzed env sequences of early HIV-1 clonal variants from 31 individuals with diverse levels of CrNA 2–4 years post-seroconversion. These sequences revealed a number of Env signatures that coincided with CrNA development. These included a statistically shorter variable region 1 and a lower probability of glycosylation as implied by a high ratio of NXS versus NXT glycosylation motifs. Furthermore, lower probability of glycosylation at position 332, which is involved in the epitopes of many broadly reactive neutralizing antibodies, was associated with the induction of CrNA. Finally, Sequence Harmony identified a number of amino acid changes associated with the development of CrNA. These residues mapped to various Env subdomains, but in particular to the first and fourth variable region as well as the underlying α2 helix of the third constant region.

Conclusions
These findings imply that the development of CrNA might depend on specific characteristics of early Env. Env signatures that correlate with the induction of CrNA might be relevant for the design of effective HIV-1 vaccines.
Combined effects of C225 and 125-iodine seed radiation on colorectal cancer cells
Authors: Liu Jingjia , Wang Hao , Qu Ang , Li Jinna , Zhao Yong , Wang Junjie 
Published: September 2013

Abstract

Background
To characterize the effect of combined treatment of the anti-epidermal growth factor receptor (EGFR) monoclonal antibody C225 and 125-iodine (125I) seed radiation in human colorectal cancer.

Methods
We treated LS180 cells with 125I continuous low dose rate radiation in the presence and absence of 100 nM C225. The clonogenic capacity, cellular proliferation, cell cycle distribution, apoptosis, and molecular pathways of the cells following the treatments were analyzed in vitro.

Results
The sensitizer enhancement ratio of C225 was approximately 1.4. Treatment with C225 and radiation alone produced significant inhibition of cell growth, but combination therapy produced greater inhibition than either treatment administered alone. C225 increased the radiation-induced apoptosis and the fraction of γ-H2AX foci positive cells at 48 h after treatment. The Akt phosphorylation level was lower in the cells receiving the combination treatment than in the cells treated with radiation or C225 alone.

Conclusions
These findings indicate that C225 sensitizes LS180 cells to 125I seed radiation. Growth inhibition is mediated by inducing apoptosis and not cell cycle arrest. Additionally, we confirmed that C225 impairs DNA repair by reducing the cellular level of the DNA-PKcs and Ku70 proteins. Furthermore, the inhibition of Akt signaling activation may be responsible for the C225-mediated radiosensitization.
Propofol infusion syndrome resuscitation with extracorporeal life support: a case report and review of the literature
Authors: Mayette Michael , Gonda Jeremy , Hsu Joe L , Mihm Frederick G 
Published: September 2013

Abstract
We report a case of propofol infusion syndrome (PRIS) in a young female treated for status epilepticus. In this case, PRIS rapidly evolved to full cardiovascular collapse despite aggressive supportive care in the intensive care unit, as well as prompt discontinuation of the offending agent. She progressed to refractory cardiac arrest requiring emergent initiation of venoarterial extracorporeal membrane oxygenation (ECMO) during cardiopulmonary resuscitation (CPR). She regained a perfusing rhythm after prolonged (>8 hours) asystole, was weaned off ECMO and eventually all life support, and was discharged to home. We also present a review of the available literature on the use of ECMO for PRIS.
The Relationship Between Faculty Performance Assessment and Results on the In-Training Examination for Residents in an Emergency Medicine Training Program
Authors: Ryan James G. , Barlas David , Pollack Simcha 
Published: September 2013

AbstractBackgroundMedical knowledge (MK) in residents is commonly assessed by the in-training examination (ITE) and faculty evaluations of resident performance.ObjectiveWe assessed the reliability of clinical evaluations of residents by faculty and the relationship between faculty assessments of resident performance and ITE scores.MethodsWe conducted a cross-sectional, observational study at an academic emergency department with a postgraduate year (PGY)-1 to PGY-3 emergency medicine residency program, comparing summative, quarterly, faculty evaluation data for MK and overall clinical competency (OC) with annual ITE scores, accounting for PGY level. We also assessed the reliability of faculty evaluations using a random effects, intraclass correlation analysis.ResultsWe analyzed data for 59 emergency medicine residents during a 6-year period. Faculty evaluations of MK and OC were highly reliable (κ  =  0.99) and remained reliable after stratification by year of training (mean κ  =  0.68–0.84). Assessments of resident performance (MK and OC) and the ITE increased with PGY level. The MK and OC results had high correlations with PGY level, and ITE scores correlated moderately with PGY. The OC and MK results had a moderate correlation with ITE score. When residents were grouped by PGY level, there was no significant correlation between MK as assessed by the faculty and the ITE score.ConclusionsResident clinical performance and ITE scores both increase with resident PGY level, but ITE scores do not predict resident clinical performance compared with peers at their PGY level.
Hoarseness of Voice: Presentation of Neglected Denture Esophagus
Authors: Kumar Sunil , Singh Devendra Bahadur 
Published: September 2013

ABSTRACT
Aspiration or ingestion of a foreign body is well-known in the pediatric as well as in the adult population. The majority of esophageal foreign bodies pass through the gastrointestinal tract without causing complications. However, large sharp foreign bodies like dentures and meat bones can get deeply embedded in the wall leading to life-threatening complications. We report a case of a neglected denture in a 55-year-old patient who presented with an unusual complaint as hoarseness of voice and was removed with the help of rigid esophagoscope.

How to cite this article
Kumar S, Singh DB. Hoarseness of Voice: Presentation of Neglected Denture Esophagus. Int J Prosthodont Restor Dent 2013;3(1):30-32.
Management of a Complicated Crown-Root Fracture using Single-Visit Endodontic Treatment and Fiber Post as an Intracanal Anchorage
Authors: Bansode Pradnya Vilas , Pathak Seema Dhananjay , Deore Rahul Bhikanrao 
Published: September 2013

ABSTRACT
This case report describes the management of complicated crown-root fracture of a maxillary central incisor. Initially, the fractured fragment was stabilized by splinting it with composite and wire splint to adjacent teeth. During next appointment single-visit endodontic treatment was performed, the fractured crown portion was reattached using fiber post and composite resin. Success was achieved by normality in function, esthetics, health of tooth and surrounding periodontal structures. This reattachment technique presents several advantages, such as better and long-lasting esthetics, improved function and a positive psychological response, faster and less complicated procedure. The main objective of the presented technique restoration is to provide highly conservative approach that combines esthetics and function. Advantages, disadvantages and prognosis of this treatment approach are discussed.

How to cite this article
Bansode PV, Pathak SD, Deore RB. Management of a Complicated Crown-Root Fracture using Single-Visit Endodontic Treatment and Fiber Post as an Intracanal Anchorage. Int J Prosthodont Restor Dent 2013; 3(1):33-36.
Lanthanide Nanoparticles for Medical Imaging
Authors: Laurent Sophie , Elst Luce Vander , Muller Robert N. 
Published: September 2013

Abstract

This article briefly reviews the methods for the synthesis and characterization of lanthanide nanoparticles (NPs) with luminescent and/or magnetic properties. Lanthanide ions exhibit advantageous optical properties, such as high photostability, a long luminescence lifetime, narrow emission bands, and a broad absorption band. Different nanosystems are described in terms of their biomedical applications: luminescent LaF
3
NPs (the most chosen host matrix), persistent luminescence NPs (Ln‐doped Ca
0.2
Mg
0.9
Zn
0.9
Si
2
O
6
NPs), upconversion NPs (NaYF
4
), and paramagnetic NPs (Gd complexes on Au NPs or on silica NPs).
Decision‐making processes for the uptake and implementation of family‐based therapy by eating disorder treatment teams: A qualitative study
Authors: Kimber Melissa , Couturier Jennifer , Jack Susan , Niccols Alison , Van Blyderveen Sherry , McVey Gail 
Published: September 2013

ABSTRACTObjectiveTo explore the decision‐making processes involved in the uptake and implementation of evidence‐based treatments (EBTs), namely, family‐based treatment (FBT), among therapists and their administrators within publically funded eating disorder treatment programs in Ontario, Canada.MethodFundamental qualitative description guided sampling, data collection, and analytic decisions. Forty therapists and 11 administrators belonging to a network of clinicians treating eating disorders completed an in‐depth interview regarding the decision‐making processes involved in EBT uptake and implementation within their organizations. Content analysis and the constant comparative technique were used to analyze interview transcripts, with 20% of the data independently double‐coded by a second coder.ResultsTherapists and their administrators identified the importance of an inclusive change culture in evidence‐based practice (EBP) decision‐making. Each group indicated reluctance to make EBP decisions in isolation from the other. Additionally, participants identified seven stages of decision‐making involved in EBT adoption, beginning with exposure to the EBT model and ending with evaluating the impact of the EBT on patient outcomes. Support for a stage‐based decision‐making process was in participants' indication that the stages were needed to demonstrate that they considered the costs and benefits of making a practice change. Participants indicated that EBTs endorsed by the Provincial Network for Eating Disorders or the Academy for Eating Disorders would more likely be adopted.DiscussionFuture work should focus on integrating the important decision‐making processes identified in this study with known implementation models to increase the use of low‐cost and effective treatments, such as FBT, within eating disorder treatment programs. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:32–39)
Four Discrete Transition Metal Complexes Involving Pyridyl‐substituted Nitronyl Nitroxide: Syntheses, Crystal Structures, and Magnetic Properties
Authors: Zhou Jie , Du Lin , Hu Yan , Chen Peng , Li Bin , Zhao Qi‐Hua 
Published: September 2013

AbstractFour discrete metal‐radical complexes, [Cu(p‐MePh‐COO)2(NITpPy)2] (1), [Ni(m‐MePhCOO)2(NITpPy)2(H2O)2]·(CH3‐OH)2 (2), [Mn(p‐MePhCOO)2(NITpPy)2(H2O)2] (3), and [Mn(m‐MePhCOO)2(NITpPy)2(H2O)2] (4) [NITpPy = 2‐(4‐pyridyl)‐4,4,5,5‐tetramethyl‐4,5‐dihydro‐1H‐imidazolyl‐1‐oxyl‐3‐oxide] were synthesized and characterized by elemental analyses, IR spectroscopy, PXRD, single‐crystal X‐ray diffraction, and magnetic susceptibility. For the four complexes, the crystal structural analyses indicate that the two radical ligands coordinated to the metal ions by the nitrogen atoms of the pyridine rings form three spin complexes, where toluates act as co‐ligands. Weak antiferromagnetic interactions [JCu–Rad = –6.75 cm–1 (1), JCo–Rad = –4.15 cm–1 (2), JMn–Rad = –0.22 cm–1 (3), and JMn–Rad = –3.74 cm–1 (4)] were observed, spin polarization mechanism and orbital symmetry are used to explain the magnetic coupling in these complexes.
On integrating confidentiality and functionality in a formal method
Authors: Banks Michael J. , Jacob Jeremy L. 
Published: September 2013

Abstract

This paper proposes a formal method, based on
Circus
, for developing software systems that respect a joint specification of functionality and confidentiality attributes. We extend the semantics of
Circus
to capture the information that users can infer about a system’s behaviour, enabling confidentiality and functionality attributes of a system to be specified together. We represent inconsistencies between functionality and confidentiality properties as miracles, rendering insecure functionality infeasible. We present techniques for verifying that a system design’s functionality and confidentiality attributes are mutually consistent, and for ensuring that consistency is maintained by refinement steps.
Fatty Acids in Heterocyclic Synthesis. Part XIV: Synthesis of Surface Active Agents from Some Novel Class of Oxadiazole, Thiadiazole and Triazole Derivatives Having Microbiological Activities
Authors: Gad El‐Karim Iman A. , Amine Mahasen S. , Mahmoud Amal A. , Gouda Alaa S. 
Published: September 2013

AbstractReaction of stearic acid with semicarbazide in refluxing POCl3 afforded 2‐amino‐5‐heptadecyl 1,3,4‐oxadiazole. Acylation of the amino group with acetic anhydride, ethyl chloroacetate and chloroacetic acid gave amide and β‐amino acid derivatives. These compounds were cyclized to imidazo[2,1‐b]oxadiazole derivatives by two different techniques. Treating the starting oxadiazole compound with P2S5, hydroxyl amine and hydrazine hydrate in benzene afforded thiadiazole and triazole derivatives. Unexpectedly, triazolo[3,4‐b][1,3,4]oxadiazole derivative was obtained when 1,3,4‐oxadiazole derivative was refluxed with hydrazine hydrate in ethanol. The biological activities of the synthesized compounds were screened in vitro against some gram positive and gram negative bacteria and fungi. Addition of quantitative amount of propylene oxide units (3, 5, 7 mol) to the synthesized compounds afforded new nonionic surfactants. The physico‐chemical and surface properties of the novel synthesized surfactants such as surface and interfacial tension, cloud point, wetting time, emulsion stability, foam height, CMC, resistance to hydrolysis and their biodegradability were investigated. In addition, surface parameters including effectiveness (πCMC), efficiency (PC20), maximum surface excess (Γmax) and (Amin) were examined.