bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mammographic Breast Density and Subsequent Risk of Breast Cancer in Postmenopausal Women According to the Time Since the Mammogram
Authors: Yaghjyan Lusine , Colditz Graham A. , Rosner Bernard , Tamimi Rulla M. 
Published: April 2013

Abstract
Background: Few studies have shown that the association between mammographic breast density and breast cancer persists for up to 10 years after the mammogram. We investigated associations of percent density, absolute dense, and nondense areas with breast cancer risk according to the time since the mammogram.
Methods: This study included 1,028 incident breast cancer cases diagnosed within the Nurses' Health Study and 1,780 matched controls. Breast density was measured from digitized film images with computerized techniques. Information on breast cancer risk factors was obtained prospectively from the biennial questionnaires before the date of cancer diagnosis for cases and their matched controls. The data were analyzed with logistic regression.
Results: Breast cancer risk increased with increasing percent density and increasing absolute dense area and decreased with increasing nondense area. In multivariate analysis, the magnitude of the association between percent density and breast cancer was similar when the time since the mammogram was &lt;2, 2 to &lt;5, and 5 to &lt;10 years [density ≥50% vs.&lt;10%: ORs, 3.12; 95% confidence interval (CI): 1.55–6.25, 5.35 (95% CI: 2.93–9.76), and 3.91 (95%CI: 2.22–6.88), respectively]. Similarly, the magnitude of association between quartiles of dense and nondense areas and breast cancer risk were similar across the time strata. We found no interactions between the time since the mammogram and breast density measures (Pinteraction &gt; 0.05).
Conclusions: Patterns of the associations between percent density, absolute dense, and nondense area with breast cancer risk persist for up to 10 years after the mammogram.
Impact: A one-time density measure can be used for long-term breast cancer risk prediction. Cancer Epidemiol Biomarkers Prev; 22(6); 1110–7. ©2013 AACR.
Epigenetic Control of NF-κB-Dependent FAS Gene Transcription during Progression of Myelodysplastic Syndromes
Authors: Ettou Sandrine , Humbrecht Catherine , Benet Blandine , Billot Katy , d'Allard Diane , Mariot Virginie , Goodhardt Michele , Kosmider Olivier , Mayeux Patrick , Solary Eric , Fontenay Michaela 
Published: April 2013

Abstract
The death domain containing TNF receptor 6 (CD95/Fas) is a direct target for the NF-κB transcription factor and is repressed in solid tumors such as colon carcinomas. Previously, we reported that the Fas death receptor, while overexpressed in low-risk myelodysplastic syndromes (MDS), becomes undetectable on CD34+ progenitors when the disease progresses to secondary acute myeloid leukemia (AML). This study determined the interplay between NF-κB and Fas during MDS progression. We first observed that Fas was induced by TNF-α in the HL60 cell line. In these cells, p65 (RELA) was associated with the FAS promoter, and inhibition of the NF-κB pathway by an IKKα inhibitor (BAY11-7082) or lentiviral expression of a nondegradable mutant of IκBα (IκSR) blocked Fas expression. In contrast, TNF-α failed to induce Fas expression in the colon carcinoma cell line SW480, due to hypermethylation of the FAS promoter. Azacitidine rescued p65 binding on FAS promoter in vitro, and subsequently Fas expression in SW480 cells. Furthermore, inhibition of the NF-κB pathway decreased the expression of Fas in MDS CD45loCD34+ bone marrow cells. However, despite the nuclear expression of p65, Fas was often low on CD45loCD34+ AML cells. TNF-α failed to stimulate its expression, while azacitidine efficiently rescued p65 binding and Fas reexpression. Overall, these data suggest that DNA methylation at NF-κB sites is responsible for FAS gene silencing. Mol Cancer Res; 11(7); 724–35. ©2013 AACR.
Neo-Pentecostal Spirituality and Theology of Creativity in the Work of Barbara A. Holmes
Authors: Ware Frederick L. 
Published: April 2013

Abstract
The works of black Pentecostal scholars who are members of classical Pentecostal denominations are well recognized. Less is known, however, about the work of black Pentecostal scholars from denominations rooted in different historical movements. One such Pentecostal scholar worthy of recognition is Barbara A. Holmes. While she self-identifies as Pentecostal/Charismatic, she is more accurately classified as neo-Pentecostal. The story of her spiritual journey reveals the complex routes and profound contributions of Pentecostalism toward the Charismatic movement in historic denominations like the United Church of Christ/Disciples of Christ Church. The influence of Pentecostalism on Holmes’s scholarship is most evident in her focus on spirituality and quest for a theology of creativity.
Subject to Spirit: The Promise of Pentecostal Feminist Pneumatology and Its Witness to Systematics
Authors: Rees Janice 
Published: April 2013

Abstract
The emergence of feminist Pentecostal studies poses a sharp challenge to both systematic theology and gender studies. The experiences of Pentecostal women, often in non-Western contexts, confront common assumptions regarding women’s ritual experience and the emergence of subjectivity. This paper will argue for an integration of insights from feminist Pentecostalism into the discipline of systematic theology. I explore the emergence of subjectivity in Pentecostal women in relation to the Holy Spirit and argue that a Pentecostal and feminist approach to pneumatology brings the critical elements together. This produces a clearer vision of the intimate relation between the doctrine of God and an embodied community of women (and men), thereby creating room within the systematic discipline to explore the boundaries of subjectivity itself.
Toward Useable Categories of “Women’s Experiences” and “Power”: A Canadian Feminist Pentecostal Considers the Work of Margaret Kamitsuka and Kwok Pui-lan
Authors: Holmes Pamela M.S. 
Published: April 2013

Abstract
This article explores the potential of, and problems associated with, the use of the concept of “women’s experiences” within feminist Pentecostalism, including the ways in which “power” is being exercised by, for, and against Pentecostal women. The exploration unfolds in dialogue with Margaret D. Kamitsuka’s Feminist Theology and the Challenge of Difference, which utilizes poststructuralist theory and Foucault’s work to demonstrate the potential of difference, and Kwok Pui-lan’s Postcolonial Imagination and Feminist Theology, which highlights the realities that many majority-world feminists face as they seek to address their own realities using the category of “strategic essentialism.” As the argument unfolds, Caucasian, first-world feminist Pentecostals are encouraged to make it explicit within their work that no one particular, located subset of Pentecostal women and their experiences can be generalized to speak for all. Rather, more privileged feminist Pentecostal theologians are encouraged to intentionally include diverse Pentecostal women’s voices in their scholarship.
Articular Cartilage Repair With Magnetic Mesenchymal Stem Cells
Authors: Kamei Goki , Kobayashi Takaaki , Ohkawa Shingo , Kongcharoensombat Wirat , Adachi Nobuo , Takazawa Kobun , Shibuya Hayatoshi , Deie Masataka , Hattori Koji , Goldberg Jeffrey L. , Ochi Mitsuo 
Published: April 2013

Background: Cell therapies are hampered by the difficulty of delivering cells to and retaining them in target tissues long enough to repair or regenerate local tissues. Hypothesis: Magnetic-assisted delivery of magnetically labeled mesenchymal stem cells (m-MSCs) would be rapid, allowing for chondrogenic differentiation and functional joint repair without replacement. Study Design: Controlled laboratory study. Methods: Sixteen mini-pigs aged 6 to 7 months were used. A full-thickness cartilage defect was created in the center of the patella with a cylindrical punch (diameter, 6 mm). At 4 weeks after creation of the cartilage defects, the animals were divided into 3 treatment groups: In the M group, m-MSCs (5 × 106 cells) were injected and accumulated to the cartilage defect using an external magnetic force (1.5 T) for 10 minutes; in the G group, the patella was faced upward, filled with MSCs (5 × 106 cells), and held for 10 minutes; and in the C group, only phosphate-buffered saline was injected. The regenerated cartilage was evaluated in 5 knees in each of the 3 groups by arthroscopic surgery at 6 and 12 weeks and histological and ultrasound evaluation at 12 and 24 weeks. Results: The mean arthroscopic scores at 6 weeks were 10.4 ± 1.10 in the M group, 8.8 ± 0.84 in the G group, and 7.4 ± 0.89 in the C group. There was a statistically significant difference between the M group and the other 2 groups. The mean arthroscopic scores at 12 weeks were 12.8 ± 1.30 (M group), 10.5 ± 1.30 (G group), and 9.5 ± 0.58 (C group), with a statistically significant difference between the M and C groups. The mean histological scores using the Wakitani scoring system at 12 weeks were 2.8 ± 0.96 (M group), 5.4 ± 0.55 (G group), and 6.0 ± 2.20 (C group), and the mean histological scores at 24 weeks were 2.4 ± 1.50 (M group), 3.5 ± 0.56 (G group), and 5.3 ± 1.50 (C group). The mean histological scores at 12 weeks were significantly better in the M group than in the other groups, and the M group maintained a significantly better histological score than did the C group at 24 weeks. Conclusion: The m-MSCs had no adverse effect on chondrogenic differentiation, and m-MSCs delivered by magnetic field application repaired cartilage defects. Clinical Relevance: The clinical application of this novel stem cell delivery system is a potential therapeutic option for treating cartilage defects and may be more applicable throughout the body than traditional methods.
Intermediate-Term Results Following First Metatarsal Cheilectomy
Authors: Bussewitz Bradly W. , Dyment Macaira M. , Hyer Christopher F. 
Published: April 2013

Hallux rigidus is a term describing degenerative joint disease (DJD) to the first metatarsal phalangeal joint (MTPJ). It is the most common DJD encountered in the foot and is the second most common pathology of the great toe behind hallux valgus. The goal of a cheilectomy is to relieve pain and increase MTPJ motion. Critical evaluation of the cheilectomy must include longevity of desired results. The primary goal of this study was to determine how long a cheilectomy can be expected to last before an arthrodesis or joint destructive procedure is performed, if ever. We examined 189 cheilectomies with a mean radiographic follow-up of 235 days and mean chart review follow-up of 1184 days (3.2 years). Analysis showed 5 repeat cheilectomies, 1 interpositional arthroplasty, and only 2 arthrodeses subsequently performed. This retrospective study provides intermediate term evidence that cheilectomy is an appropriate procedure for stages 1, 2, and 3 first MTPJ DJD with reliable, lasting results. Levels of Evidence: Therapeutic, Level III
Trends and Factors Associated with Initial and Recurrent Methicillin-Resistant Staphylococcus aureus (MRSA) Skin and Soft-Tissue Infections among HIV-Infected Persons
Authors: Vyas Kartavya J. , Shadyab Aladdin H. , Lin Chii-Dean , Crum-Cianflone Nancy F. 
Published: April 2013

Background: Factors associated with initial methicillin-resistant Staphylococcus aureus (MRSA) skin and soft-tissue infections (SSTIs) and their recurrence have not been fully elucidated among HIV-infected persons. Methods: We retrospectively evaluated a large cohort of HIV-infected patients from 1993 to 2010 for culture-proven MRSA SSTIs. Separate logistic regression models evaluated factors associated with initial and recurrent infections. Results: Of the 794 patients, 63 (8%) developed an initial infection (19.8 infections/1000 person years [PY]); risk factors included CD4 count <500 cells/mm3 and HIV RNA level ≥400 copies/mL ( P < .01), US Centers for Disease Control and Prevention (CDC) stage C versus A/B ( P < .01), and injection drug use (IDU, P < .01). In all, 27% developed recurrence (206 infections/1000 PY); risk factors included hospital admission ( P = .02). Minocycline for treatment of the initial infection was associated with an 80% decreased odds for recurrence ( P = .03). Conclusion: HIV control and avoidance of IDU may be useful in reducing rates of MRSA SSTIs among HIV-infected persons.
Whole-exome sequencing in adult ETP-ALL reveals a high rate of DNMT3A mutations
Authors: Neumann Martin , Heesch Sandra , Schlee Cornelia , Schwartz Stefan , Gökbuget Nicola , Hoelzer Dieter , Konstandin Nikola P. , Ksienzyk Bianka , Vosberg Sebastian , Graf Alexander , Krebs Stefan , Blum Helmut , Raff Thorsten , Brüggemann Monika , Hofmann Wolf-Karsten , Hecht Jochen , Bohlander Stefan K. , Greif Philipp A. , Baldus Claudia D. 
Published: April 2013

Key Points
Exome sequencing of adult ETP-ALL reveals new recurrent mutations; in particular, DNMT3A is frequently mutated in adult ETP-ALL. More than 60% of all adult patients with ETP-ALL harbor a mutation that could potentially be targeted by a specific therapy.
Comparison of automated and manual FISH for evaluation of HER2 gene status on breast carcinoma core biopsies
Authors: Öhlschlegel Christian , Kradolfer Doris , Hell Margreth , Jochum Wolfram 
Published: April 2013

Abstract

Background
Positive HER2 status identifies breast carcinomas that might respond to trastuzumab treatment. Manual HER2 fluorescent in situ hybridisation (FISH) is the most readily used method to detect HER2 gene amplification which defines positive HER2 status in addition to HER2 protein overexpression. Automation of HER2 FISH may improve HER2 gene testing. The aim of our study was to evaluate an automated HER2 FISH assay for assessing the HER2 genomic status.

Methods
Core biopsies of 100 invasive breast carcinomas were analysed in parallel using the PathVysion™ HER-2 DNA Probe Kit and the Leica HER2 FISH System for BOND™. To assess inter-method agreement, concordance analysis was performed for various numerical and categorical HER2/CEP17 FISH parameters.

Results
Carcinomas with all HER2 immunohistochemical scores were included (0+: 20; 1+: 20; 2+: 30; 3+: 30). Using either HER2/CEP17 ratio >2.2 or ≥2.0 as criterion for HER2 amplification, high levels of concordance were observed between automated and manual FISH (concordance rate 96%, κ coefficient 0.92). High levels of inter-method agreement were also found for HER2 copy number, CEP17 copy number, HER2/CEP17 ratio, the percentage of carcinoma cells with HER2/CEP17 ratio >2.2, and the presence of HER2 genetic heterogeneity, HER2 clusters and CEP17 polyploidy.

Conclusions

HER2 testing using automated FISH is feasible on breast carcinoma core biopsies. Automated HER2 FISH using the Leica HER2 FISH System for BOND is a practical and efficient alternative to manual HER2 FISH in evaluating the HER2 status of primary invasive breast carcinomas.
Diesel exhaust but not ozone increases fraction of exhaled nitric oxide in a randomized controlled experimental exposure study of healthy human subjects
Authors: Barath Stefan , Mills Nicholas L , Ädelroth Ellinor , Olin Anna-Carin , Blomberg Anders 
Published: April 2013

Abstract

Background
Fraction of exhaled nitric oxide (FENO) is a promising non-invasive index of airway inflammation that may be used to assess respiratory effects of air pollution. We evaluated FENO as a measure of airway inflammation after controlled exposure to diesel exhaust or ozone.

Methods
Healthy volunteers were exposed to either diesel exhaust (particle concentration 300 μg/m3) and filtered air for one hour, or ozone (300 ppb) and filtered air for 75 minutes. FENO was measured in duplicate at expiratory flow rates of 10, 50, 100 and 270 mL/s before, 6 and 24 hours after each exposure.

Results
Exposure to diesel exhaust increased FENO at 6 hours compared with air at expiratory flow rates of 10 mL/s (p = 0.01) and at 50 mL/s (p = 0.011), but FENO did not differ significantly at higher flow rates. Increases in FENO following diesel exhaust were attenuated at 24 hours. Ozone did not affect FENO at any flow rate or time point.

Conclusions
Exposure to diesel exhaust, but not ozone, increased FENO concentrations in healthy subjects. Differences in the induction of airway inflammation may explain divergent responses to diesel exhaust and ozone, with implications for the use of FENO as an index of exposure to air pollution.
ZnO nanorod array-coated mesh film for the separation of water and oil
Authors: Li Hong , Li Yushan , Liu Qinzhuang 
Published: April 2013

Abstract
Dense and vertically aligned ZnO nanorod arrays with a large area have been fabricated successfully on the stainless steel mesh by a simple chemical vapor deposition method. The coated mesh exhibited both superoleophilic and superhydrophobic properties, even if it was not modified by low surface energy materials. The separation efficiencies were more than 97% in the filtration of water and oil. Besides, the wettability of the coated mesh was still stable after it was soaked in the corrosive solutions for 1 h. A detailed investigation showed that the coated mesh has the best superhydrophobic property when the stainless steel mesh pore size was about 75 μm.
A mutual GrabCut method to solve co-segmentation
Authors: Gao Zhisheng , Shi Peng , Karimi Hamid Reza , Pei Zheng 
Published: April 2013

Abstract
Co-segmentation aims at segmenting common objects from a group of images. Markov random field (MRF) has been widely used to solve co-segmentation, which introduces a global constraint to make the foreground similar to each other. However, it is difficult to minimize the new model. In this paper, we propose a new Markov random field-based co-segmentation model to solve co-segmentation problem without minimization problem. In our model, foreground similarity constraint is added into the unary term of MRF model rather than the global term, which can be minimized by graph cut method. In the model, a new energy function is designed by considering both the foreground similarity and the background consistency. Then, a mutual optimization approach is used to minimize the energy function. We test the proposed method on many pairs of images. The experimental results demonstrate the effectiveness of the proposed method.
The anatomical evaluation of the dental arches using cone beam computed tomography - an investigation of the availability of bone for placement of mini-screws
Authors: Pan Feng , Kau Chung H , Zhou Hong , Souccar Nada 
Published: April 2013

Abstract

Objective
To assess the amount of maxillary and mandibular inter-radicular bone mass and determine the most reliable mini-screw placement sites.

Materials and methods
Retrospective Cone Beam Computed Tomography (CBCT) images of 40 Angle Class I subjects (20 females, 20 males, aged 16 to 32) were obtained. Measurements on the buccal (BI), medial (MI) and lingual (LI) sides of the inter-radicular spaces were taken at 0, 1, 2, 3, 4, 5 mm from the cemento-enamel junction (CEJ) in an apical direction.

Results
The male and female BI scores ranged from 2.99±0.73 mm to 6.18±1.03 mm and 2.69±0.84 mm to 6.21±1.22 mm respectively. The male and female MI scores ranged from 1.36±0.38 mm to 4.50±0.99 and 1.53±0.66 to 4.77±1.99 mm respectively. LI scores ranged from 2.37±0.70 to 6.47±1.0 mm and 2.45±0.56 mm and 6.66±1.33 mm respectively. In both maxillary and mandibular arch, the inter-radicular space increased in the apical direction except for the buccal and medial inter-radicular spaces between the maxillary first and second molars.

Conclusion
The medial inter-radicular spaces are the decisive parameter for mini-screw placement. In the maxillary arch, regions between central and lateral incisors, lateral incisor and canine, first and second molars are not viable for mini-screw insertion. The residual inter-radicular regions are proper for implantation at 3 mm above the CEJ. In the mandible, the regions between incisors and canines are too narrow for mini-screw insertion and the reliable sites for mini-screws are regions between premolars, molars or first molar and second premolar at 2 mm below the CEJ.
Ki-67 labeling in canine perianal glands neoplasms: a novel approach for immunohistological diagnostic and prognostic
Authors: Pereira Rodrigo Storti , Schweigert Augusto , Melo Guilherme Dias de , Fernandes Fernando Vissani , Sueiro Felipe Augusto Ruiz , Machado Gisele Fabrino 
Published: April 2013

Abstract

Background
The antibody Ki-67 is a reliable and easy tool to accurately assess the growth fraction of neoplasms in humans and animals, and it has been used to predict the clinical outcome. Therefore, the aim of the present study was to investigate the immunohistochemical expression pattern of Ki-67 in normal and neoplastic perianal glands of dogs to evaluate the possible use of this proliferation marker as an ancillary method of perianal tumor diagnosis. We studied 42 cases of perianal gland neoplasms including adenomas (n = 15), epitheliomas (n = 15), and carcinomas (n = 12). As controls, 13 tissue samples from normal perianal glands were used. A Ki-67 index was established by a computer-assisted image analysis and compared with manual counting.

Results
Out of the 42 cases of perianal gland neoplasms, 34 were from males and eight from females. Recurrence was reported in 14 cases, being higher (8/12) in carcinomas. Immunostaining for Ki-67 revealed that the carcinomas showed a higher proliferation rate (9.87%) compared to groups of epitheliomas (2.66%) and adenomas (0.36%). For adenomas and epitheliomas of the perianal glands the computer-assisted counting and the manual counting gave similar results; however, only the computer-assisted image analysis was efficient to predict the perianal gland carcinoma recurrence.

Conclusion
Since there were significant differences in the number of Ki-67-positive nuclei, this marker proved to be effective in helping the classification of perianal gland neoplasms and to refine the diagnosis criteria, especially in those samples with high variation in morphology/area. Also, higher Ki-67 index is related to recurrence in cases of perianal gland carcinomas. Further, the computer-assisted image analysis proved to be a fast and reliable method to assess the Ki-67 index in perianal gland neoplasms.
Synthesis and characterization of ZnO nanostructures using palm olein as biotemplate
Authors: Ramimoghadam Donya , Hussein Mohd Zobir Bin , Taufiq-Yap Yun Hin 
Published: April 2013

Abstract

Background
A green approach to synthesize nanomaterials using biotemplates has been subjected to intense research due to several advantages. Palm olein as a biotemplate offers the benefits of eco-friendliness, low-cost and scale-up for large scale production. Therefore, the effect of palm olein on morphology and surface properties of ZnO nanostructures were investigated.

Results
The results indicate that palm olein as a biotemplate can be used to modify the shape and size of ZnO particles synthesized by hydrothermal method. Different morphology including flake-, flower- and three dimensional star-like structures were obtained. FTIR study indicated the reaction between carboxyl group of palm olein and zinc species had taken place. Specific surface area enhanced while no considerable change were observed in optical properties.

Conclusion

Phase-pure ZnO particles were successfully synthesized using palm olein as soft biotemplating agent by hydrothermal method. The physico-chemical properties of the resulting ZnO particles can be tuned using the ratio of palm olein to Zn cation.