bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing the Efficacy of Eletriptan for Migraine in Women During Menstrual and Non‐Menstrual Time Periods: A Pooled Analysis of Randomized Controlled Trials
Authors: Bhambri Rahul , Martin Vincent T. , Abdulsattar Younos , Silberstein Stephen , Almas Mary , Chatterjee Anjan , Ramos Elodie 
Published: October 2013

ObjectiveTo assess the efficacy and tolerability of eletriptan in treating migraine attacks occurring within the defined menstrual time period of 1 day before and 4 days after onset of menstruation (menses days –1 to +4) compared with attacks occurring during non‐menstrual time periods (occurring outside of menses days –1 to +4).BackgroundMigraine attacks during menses have been associated with longer duration, higher recurrence rates, greater treatment resistance, and greater functional disability than those not associated with menses. The efficacy of eletriptan in treating migraine attacks associated with menstruation vs those outside a defined menstrual period has not been evaluated.MethodsData were pooled from 5 similarly designed, double‐blind, randomized, placebo‐controlled trials of eletriptan 20 mg/40 mg/80 mg. Two groups were defined for this analysis: women with a single index migraine beginning during the menstrual (group 1) and non‐menstrual (group 2) time periods. End points of interest were headache response at 2 hours, migraine recurrence and sustained responses for nausea, photo/phonophobia, and function. Logistic regression was used to compare group 1 vs group 2 and each eletriptan dose (20, 40, or 80 mg) vs placebo. Adverse events were also assessed.ResultsOf 3217 subjects pooled from 5 studies, 2216 women were either in group 1 (n = 630) or group 2 (n = 1586). Rates of headache response at 2 hours were similar in group 1 vs group 2 (odds ratio [OR] = 1.11 [95% confidence interval (CI) 0.91, 1.36]; P = .2944). The rate of headache recurrence was significantly higher in group 1 vs group 2 (26.8% vs 18.6%; OR = 1.67 [95% CI 1.23, 2.26]; P < .001). The odds of achieving sustained nausea responses were significantly lower in group 1 than in group 2 (OR = 0.70 [95% CI 0.54, 0.92]; P = .0097). There was no significant difference between group 1 and group 2 in the odds of achieving a sustained photo/phonophobia and functional response (OR = 0.96 [95% CI 0.77, 1.20]; P = .7269 and OR = 1.14 [95% CI 0.87, 1.50]; P = .3425, respectively). Adverse events were comparable between group 1 and group 2.ConclusionsTwo‐hour headache outcome measures were similar in women treated with eletriptan both within and outside of the defined menstrual time period (menses days –1 to +4). The main treatment differences between the 2 groups occurred 2‐24 hours post‐treatment, with higher recurrence rates and lower sustained response rates for nausea in the group treated during the menstrual time period.
Prevalence of community‐acquired methicillin‐resistant Staphylococcus aureus and antibiotic resistance in patients with atopic dermatitis in Porto Alegre, Brazil
Authors: Petry Vanessa , Lipnharski Caroline , Bessa Giancarlo R. , Silveira Vera B. , Weber Magda B. , Bonamigo Renan R. , d'Azevedo Pedro A. 
Published: October 2013

AbstractBackgroundAtopic dermatitis (AD) is a skin manifestation of atopy caused by hyperreactivity to various antigens. Studies have shown that 60–100% of patients with this condition present with colonization by Staphylococcus aureus. Given increasing rates of antimicrobial resistance, the sensitivity to antimicrobials of S. aureus colonizing atopic patients has been investigated. Cross‐sectional studies worldwide suggest that the prevalence of methicillin‐resistant S. aureus infection (MRSA) in the AD population varies from 0% to 30.8%.ObjectivesThe objectives of this study were to determinate the prevalence of S. aureus and MRSA in patients with AD in two dermatologic centers in Porto Alegre, Brazil.MethodsA total of 91 patients with AD attending two dermatologic centers in Porto Alegre were enrolled in this study from December 2009 to July 2011. Two skin swabs were taken from each patient, one from the nares and the other from a non‐infected eczematous skin lesion. The swabs were sent to the laboratory, where standard procedures to isolate bacteria and identify S. aureus, antimicrobial resistance, and sensitivity patterns were carried out. The severity of AD was defined using the Eczema Area and Severity Index (EASI).ResultsOf the 91 patients sampled, 67 (73.6%) patients were found to be positive for S. aureus colonization. Nasal swabs were positive in 55 (60.4%) patients, lesional swabs in 44 (48.4%) patients, and both lesional and nasal swabs were positive in 32 (35.2%) patients. Patients with positive swabs had a higher mean ± standard deviation EASI score [mean (9.1 ± 8.8)] compared with patients with negative swabs (3.9 ± 3.6) (P = 0.002). None of the 91 patients showed any evidence of MRSA infection. Overall, nearly 32% of the S. aureus isolated from nasal swabs and 36.40% of the S. aureus isolated from lesional swabs was resistant to erythromycin.ConclusionsThe results of this study confirm a high rate of S. aureus colonization in pediatric patients with AD and indicate a relevant association between colonization and high EASI score. No MRSA was found in cultures from this sample of patients in southern Brazil. Nearly one‐third of isolates were identified as resistant to erythromycin, an antibiotic that is commonly used in pediatric patients.
Downregulation of erythroid differentiation regulator 1 as a novel marker of skin tumors
Authors: Lee Young Bok , Kim Hee Jung , Jung Hwa Young , Park Yong Gyu , Kim Si Yong , Cho Baik Kee , Cho Daeho , Park Hyun Jeong 
Published: October 2013

SummaryBackgroundErythroid differentiation regulator 1 is decreased in malignant melanoma. However, the expression of erythroid differentiation regulator 1 has not been reported in normal epidermis, vessel, nerve, dermal adnexae, and various skin tumors.MethodsTo investigate the expression of erythroid differentiation regulator 1 in normal skin and various skin tumors, immunohistochemical analysis of normal skin, epidermal tumors, sebaceous tumors, and eccrine tumors was performed. The image analysis was quantitatively performed using HistoQuant™ software.ResultsErythroid differentiation regulator 1 was strongly expressed in the nuclei of normal epidermis, sebaceous gland, eccrine gland, vessel, and nerve. Expression of erythroid differentiation regulator 1 was weak in seborrheic keratosis, sebaceous hyperplasia, and eccrine spiradenoma. Erythroid differentiation regulator 1 was rarely observed in malignant skin tumors, including squamous cell carcinoma, basal cell carcinoma, malignant melanoma, sebaceous carcinoma, and eccrine porocarcinoma.ConclusionsThe expression of erythroid differentiation regulator 1 was negatively correlated with the malignant potential in various skin tumors. The results support the role of erythroid differentiation regulator 1 in cutaneous carcinogenesis and indicate its potential as a novel marker of skin tumors.
Downregulation of PTEN expression in psoriatic lesions
Authors: Li Yadi , Man Xiaohong , You Liping , Xiang Qing , Li Hongyan , Xu Bo , Chen Zhihua , Zhang Xiaoyan , Lian Shi 
Published: October 2013

AbstractBackgroundConsiderable studies showed that tumor suppressor phosphatase and tensin homolog (PTEN) deleted on chromosome 10 is a major tumor suppressor, which inhibits cell proliferation through inactivation of the PI3 kinase (PI3K)/Akt signal pathway. In many human tumors, there is loss of function or mutations in PTEN. In our previous study, it was found that Akt activity in psoriatic lesions increased compared with that in normal controls. However, the expression of PTEN and the correlation between PTEN and PI3K/Akt have not been investigated in patients with psoriasis.Materials and methodsSkin tissue samples were obtained from 18 patients with psoriasis and 19 healthy controls. The expressions of PTEN were measured with quantitative real‐time polymerase chain reaction (RT‐PCR) assay, Western blotting, and immunohistochemistry.ResultsQuantitative RT‐PCR analysis demonstrated that the mRNA levels of PTEN in psoriatic lesions were decreased in comparison with that in normal skin. Western blotting and immunohistochemistry analysis of PTEN showed that PTEN protein was lowly expressed in psoriatic lesions compared with that in normal controls, which suggested that the reduction of PTEN mRNA expression leads to decreased PTEN protein levels.ConclusionsThe downregulation of PTEN expressions may play a role in the overactivation of the PI3K/Akt pathway in psoriatic lesions and correlate with the hyperproliferation of psoriatic keratinocytes.
A recombinant human hyaluronidase sustained release gel for the treatment of post‐surgical edema
Authors: Nekoroski Tara , Paladini Rudolph D. , Sauder Daniel N. , Frost Gregory I. , Keller Gilbert‐A. 
Published: October 2013

AbstractBackgroundEdema commonly accompanies surgical procedures and when excessive, can adversely affect surgical outcomes. The skin extracellular matrix, including one of its primary components, hyaluronan (HA), is a significant barrier to effective drainage of accumulated edematous fluid. Recombinant human hyaluronidase (rHuPH20) is a human hyaluronidase that acts transiently and locally to depolymerize HA. A non‐liposomal gel formulation that provides a sustained release of rHuPH20 was tested in vivo in a preclinical murine model of acquired lymphedema.MethodsLymphedemic mice were injected 24 hours before surgery, and at 2 and 12 days following surgery with rHuPH20 sustained release gel (PH20 SR gel). Quantitative assessment of treatment response indicated that a single dose of PH20 SR gel resulted in accelerated resolution and reduced severity of post‐surgical edema as compared to the gel vehicle (control).ResultsStatistically significant enzymatic degradation of HA was demonstrated up to 5 mm from the injection site, and histological analysis confirmed removal of HA up to 72 hours following PH20 SR gel administration.ConclusionsThese results demonstrate sustained hyaluronidase enzymatic activity that promotes diffusion of accumulated post‐surgical edematous fluid, suggesting that PH20 SR gel may be a useful adjuvant in promoting postoperative edema resolution.
A case of pachyonychia congenita with unusual manifestations: an unusual type or a new syndrome?
Authors: Gönül Müzeyyen , Gül Ülker , Kılıç Arzu , Soylu Seçil , Koçak Oğuzhan , Demiriz Murat 
Published: October 2013

AbstractA 30‐year‐old man presented with lesions on his oral mucosa and soles. There were no similar complaints in his family members. The dermatological examination revealed follicular hyperkeratosis on his trunk and upper extremities and flesh‐colored, firm cystic lesions on his axillae. He had focal, painful, hyperkeratotic areas sited particularly on both his soles and palms. In addition to these, leukokeratosis and ulcerative areas on buccal, labial mucosa, tongue, and at corners of the mouth, and complete loss of teeth was observed. The proximal layering was revealed on all of his nails. The laboratory investigations produced normal results except the deficiency of immunoglobulin A. The psychiatric examination revealed mild mental retardation. Keratin gene (KRT6a, KRT6b, KRT16, and KRT17) mutations for pachyonychia congenita were negative. He got removable dental prosthesis because of inadequate alimentation. Squamous cell cancer developed on lower lip mucosa during follow‐up.We present an individual who had different nail dystrophy, epidermal cysts, mental retardation, blepharitis, complete loss of teeth, and negative keratin gene mutations for pachyonychia congenita and developed squamous cell cancer on the oral leukokeratosis lesions. We think that the present case may be an unusual new type of pachyonychia congenita.
European Financial Management Association (EFMA) Annual Meetings: a Retrospective Evaluation
Authors: Doukas John A. , Walter Andreas 
Published: October 2013

AbstractWe provide a retrospective evaluation of the European Financial Management Association (EFMA) annual meetings from 2001 to 2010. In the 10‐year investigation period, 2,986 papers have been presented at the annual EFMA meetings. Presented research has, in accordance with the objective of the EFMA, a strong focus on European financial topics, and most accepted papers were written by European authors. Our analysis reveals that empirical papers analysing European datasets have a positive impact on the likelihood of being published in the European Financial Management (EFM), the journal of the EFMA, compared to other peer‐reviewed journals. This evidence appears to be consistent with the EFM objectives to foster more research on European finance issues.
Uncertainties in Climate Models: Living with Uncertainty in an Uncertain World
Authors: Lee Lindsay 
Published: October 2013

Abstract
Climate change is hugely complicated, physically and statistically. Debate rages about predictions and the uncertainties within them. Understanding such uncertainties is vital. Lindsay Lee works on the Leeds University GLOMAP model of aerosols in the atmosphere and the changes they may bring. This article was a runner-up in the Significance/Young Statisticians Section writers’ competition earlier this year.
Visualising Movement: The Seagull
Authors: Demšar Urška , van Loon Emiel 
Published: October 2013

Abstract
Where does a seagull spend its day? Overcrowded diagrams don't help you to see it. More cunning designs show it all clearly. Urška Demšar and Emiel van Loon describe how visualising the geography of time and movement supports the study of animal ecology.
Receptor‐Like Kinases in Plant Innate Immunity
Authors: Wu Ying , Zhou Jian‐Min 
Published: October 2013

AbstractPlants employ a highly effective surveillance system to detect potential pathogens, which is critical for the success of land plants in an environment surrounded by numerous microbes. Recent efforts have led to the identification of a number of immune receptors and components of immune receptor complexes. It is now clear that receptor‐like kinases (RLKs) and receptor‐like proteins (RLPs) are key pattern‐recognition receptors (PRRs) for microbe‐ and plant‐derived molecular patterns that are associated with pathogen invasion. RLKs and RLPs involved in immune signaling belong to large gene families in plants and have undergone lineage specific expansion. Molecular evolution and population studies on phytopathogenic molecular signatures and their receptors have provided crucial insight into the co‐evolution between plants and pathogens.imageJian‐Min Zhou(Corresponding author)
Association analysis of fiber quality traits and exploration of elite alleles in Upland cotton cultivars/accessions (Gossypium hirsutum L.)
Authors: Cai Caiping , Ye Wenxue , Zhang Tianzhen , Guo Wangzhen 
Published: October 2013

AbstractExploring the elite alleles and germplasm accessions related to fiber quality traits will accelerate the breeding of cotton for fiber quality improvement. In this study, 99 Gossypium hirsutum L. accessions with diverse origins were used to perform association analysis of fiber quality traits using 97 polymorphic microsatellite marker primer pairs. A total of 107 significant marker‐trait associations were detected for three fiber quality traits under three different environments, with 70 detected in two or three environments and 37 detected in only one environment. Among the 70 significant marker‐trait associations, 52.86% were reported previously, implying that these are stable loci for target traits. Furthermore, we detected a large number of elite alleles associated simultaneously with two or three traits. These elite alleles were mainly from accessions collected in China, introduced to China from the United States, or rare alleles with a frequency of less than 5%. No one cultivar contained more than half of the elite alleles, but 10 accessions were collected from China and the two introduced from the United States did contain more than half of these alleles. Therefore, there is great potential for mining elite alleles from germplasm accessions for use in fiber quality improvement in modern cotton breeding.
The Effect of Condoms on Penile Vibrotactile Sensitivity Thresholds in Young, Heterosexual Men
Authors: Hill Brandon J. , Janssen Erick , Kvam Peter , Amick Erick E. , Sanders Stephanie A. 
Published: October 2013

Abstract

Introduction
Investigating the ways in which barrier methods such as condoms may affect penile sensory thresholds has potential relevance to the development of interventions in men who experience negative effects of condoms on sexual response and sensation. A quantitative, psychophysiological investigation examining the degree to which sensations are altered by condoms has, to date, not been conducted.

Aim
The objective of this study was to examine penile vibrotactile sensitivity thresholds in both flaccid and erect penises with and without a condom while comparing men who do and those who do not report condom-associated erection problems (CAEP).

Methods
Penile vibrotactile sensitivity thresholds were assessed among a total of 141 young, heterosexual men using biothesiometry. An incremental two-step staircase method was used and repeated three times for each of four conditions. Intra-class correlation coefficients (ICCs) were calculated for all vibratory assessments. Penile vibratory thresholds were compared using a mixed-model analysis of variance.

Main Outcome Measures
Penile vibrotactile sensitivity thresholds with and without a condom, erectile function measured by International Index of Erectile Function Questionnaire, and self-reported degree of erection.

Results
Significant main effects of condoms (yes/no) and erection (yes/no) were found. No main or interaction effects of CAEP were found. Condoms were associated with higher penile vibrotactile sensitivity thresholds (F[1,124] = 17.11, P &lt; 0.001). Penile vibrotactile thresholds were higher with an erect penis than with a flaccid penis (F[1,124] = 4.21, P = 0.042).

Conclusion
The current study demonstrates the feasibility of measuring penile vibratory thresholds with and without a condom in both erect and flaccid experimental conditions. As might be expected, condoms increased penile vibrotactile sensitivity thresholds. Interestingly, erections were associated with the highest thresholds. Thus, this study was the first to document that erect penises are less sensitive to vibrotactile stimulation than flaccid penises.
Determination of Aroma Volatile Diffusion Coefficients in Set‐Type Acidified Dairy Matrices of Different Composition and Microstructure by Means of the Concentration Profile Technique in Combination with Headspace Gas Chromatography
Authors: Heilig Andrej , Hahn Christian , Erpenbach Kerstin , Kübler Katya , Hinrichs Jörg 
Published: October 2013

AbstractThe diffusion of aroma volatiles in set‐type acidified dairy matrices of different composition and structure was investigated using the concentration profile technique (CPT) in combination with headspace gas chromatography (HSGC). Multiphase confocal laser scanning microscopy and puncture testing were used to characterize the micro‐ and macrostructure of the matrices. Aroma volatiles under investigation included diacetyl, (Z)‐3‐hexenol, ethyl butanoate, ethyl‐2‐methylbutanoate, (Z)‐3‐hexenyl acetate, ethyl hexanoate and limonene, and covered a wide range of hydrophobicity. CPT in combination with HSGC was found suitable to determine apparent diffusion coefficients at equilibrium. Increased overall protein content decreased the diffusivity of hydrophobic volatiles. At 4% protein content, diffusivity remained unaffected by process‐induced changes in the protein network density. Addition of milk fat substantially decreased the mobility of hydrophobic volatiles. In milk fat‐containing matrices, the addition of pectin did not change the diffusion properties of the volatiles, independent of their hydrophobicity.Practical ApplicationsThis study is relevant to the producers of acidified dairy products such as yoghurt, fresh cheese and quarg. The results specify within which boundaries several core parameters of manufacture, such as the addition of pectin, the intensity of milk heating, shearing and adaptations in protein and fat content, may be changed at a minimized risk of altered aroma delivery during consumption. This information amplifies the technological possibilities of the manufacturers and increases their flexibility in terms of product composition and processing. Aroma suppliers could use the outcomes of this study to modify the composition of their aromas based on dairy product specifications and the hydrophobicity of the individual aroma compounds they are using.
Small Deformation Rheology for Characterization of Anhydrous Milk Fat/Rapeseed Oil Samples
Authors: Rønholt Stine , Mortensen Kell , Knudsen Jes C. 
Published: October 2013

AbstractSamples of anhydrous milk fat and rapeseed oil were characterized by small amplitude oscillatory shear rheology using nine different instrumental geometrical combinations to monitor elastic modulus (G′) and relative deformation (strain) at fracture. First, G′ was continuously recorded during crystallization in a fluted cup at 5C. Second, crystallization of the blends occurred for 24 h, at 5C, in external containers. Samples were gently cut into disks or filled in the rheometer prior to analysis. Among the geometries tested, corrugated parallel plates with top and bottom temperature control are most suitable due to reproducibility and dependence on shear and strain. Similar levels for G′ were obtained for samples measured with parallel plate setup and identical samples crystallized in situ in the geometry. Samples measured with other geometries have G′ orders of magnitude lower than identical samples crystallized in situ. This emphasizes the importance of gentle sample pre handling, temperature control and preventing slip.Practical ApplicationsSmall deformation rheology is widely used to study and evaluate textural behavior of fat‐based systems. As different research groups use different geometries, a systematic evaluation of data gained using different geometrical combinations is needed. By conducting a methodic evaluation, this work provides an increased knowledge of how to characterize fat‐based systems using small deformation rheology and evaluates the relations between geometries. Because of the rigid nature of fat‐based systems, wall slip is likely to occur. Moreover, when characterizing such systems during storage and/or produced at industrial scale, in situ crystallization is not possible. In such cases, the sample must be loaded at the geometry prior to analysis. Such loading will affect the fat crystal network to some extent and consequently the data obtained. However, as the physical conditions differ between the geometries available, they affect both the fat crystal network and the tendency of wall slip to occur differently.