bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase II Study of Bendamustine in Relapsed and Refractory Hodgkin Lymphoma
Authors: Moskowitz Alison J. , Hamlin Paul A. , Perales Miguel-Angel , Gerecitano John , Horwitz Steven M. , Matasar Matthew J. , Noy Ariela , Palomba Maria Lia , Portlock Carol S. , Straus David J. , Graustein Tricia , Zelenetz Andrew D. , Moskowitz Craig H. 
Published: December 2012

Purpose Limited data exist regarding the activity of bendamustine in Hodgkin lymphoma (HL). This phase II study evaluated the efficacy of bendamustine in relapsed and refractory HL. Patients and Methods Patients with relapsed and refractory HL who were ineligible for autologous stem-cell transplantation (ASCT), or for whom this treatment failed, received bendamustine 120 mg/m2 as a 30-minute infusion on days 1 and 2 every 28 days with growth factor support. The primary end point was overall response rate (ORR). A secondary end point was referral rate to allogeneic stem-cell transplantation (alloSCT) for patients deemed eligible for alloSCT at the time of enrollment. Results Of the 36 patients enrolled, 34 were evaluable for response. Patients had received a median of four prior treatments, and 75% had relapsed after ASCT. The ORR by intent-to-treat analysis was 53%, including 12 complete responses (33%) and seven partial responses (19%). The response rate among evaluable patients was 56%. Responses were seen in patients with prior refractory disease, prior ASCT, and prior alloSCT; however, no responses were seen in patients who relapsed within 3 months of ASCT. The median response duration was 5 months. Five patients (20% of those eligible) proceeded to alloSCT after treatment with bendamustine. Grade ≥ 3 adverse events were infrequent and most commonly included thrombocytopenia (20%), anemia (14%), and infection (14%). Conclusion This study confirms the efficacy of bendamustine in heavily pretreated patients with HL. These results support current and future studies evaluating bendamustine combinations in relapsed and refractory HL.
Effectiveness of Developmental Screening in an Urban Setting
Authors: Guevara James P. , Gerdes Marsha , Localio Russell , Huang Yuanshung V. , Pinto-Martin Jennifer , Minkovitz Cynthia S. , Hsu Diane , Kyriakou Lara , Baglivo Sofia , Kavanagh Jane , Pati Susmita 
Published: December 2012

OBJECTIVE:To determine the effectiveness of developmental screening on the identification of developmental delays, early intervention (EI) referrals, and EI eligibility.METHODS:This randomized controlled, parallel-group trial was conducted from December 2008 to June 2010 in 4 urban pediatric practices. Children were eligible if they were &lt;30 months old, term, without congenital malformations or genetic syndromes, not in foster care, and not enrolled in EI. Children were randomized to receive 1 of the following: (1) developmental screening using Ages and Stages Questionnaire-II (ASQ-II and Modified Checklist for Autism in Toddlers (M-CHAT) with office staff assistance, (2) developmental screening using ASQ-II and M-CHAT without office staff assistance, or (3) developmental surveillance using age-appropriate milestones at well visits. Outcomes were assessed using an intention-to-treat analysis.RESULTS:A total of 2103 children were enrolled. Most were African-American with family incomes less than $30 000. Children in either screening arm were more likely to be identified with delays (23.0% and 26.8% vs 13.0%; P &lt; .001), referred to EI (19.9% and 17.5% vs 10.2%; P &lt; .001), and eligible for EI services (7.0% and 5.3% vs 3.0%; P &lt; .001) than children in the surveillance arm. Children in the screening arms incurred a shorter time to identification, EI referral, and EI evaluation than children in the surveillance arm.CONCLUSIONS:Children who participated in a developmental screening program were more likely to be identified with developmental delays, referred to EI, and eligible for EI services in a timelier fashion than children who received surveillance alone. These results support policies endorsing developmental screening.
Efficacy and Safety of Sitagliptin Versus Glipizide in Patients With Type 2 Diabetes and Moderate-to-Severe Chronic Renal Insufficiency
Authors: Arjona Ferreira Juan Camilo , Marre Michel , Barzilai Nir , Guo Hua , Golm Gregory T. , Sisk Christine McCrary , Kaufman Keith D. , Goldstein Barry J. 
Published: December 2012

OBJECTIVEPatients with type 2 diabetes mellitus (T2DM) and chronic kidney disease have an increased risk of micro- and macrovascular disease, but limited options for antihyperglycemic therapy. We compared the efficacy and safety of sitagliptin with glipizide in patients with T2DM and moderate-to-severe chronic renal insufficiency and inadequate glycemic control.RESEARCH DESIGN AND METHODSPatients (n = 426) were randomized 1:1 to sitagliptin (50 mg every day [q.d.] for moderate renal insufficiency and 25 mg q.d. for severe renal insufficiency) or glipizide (2.5 mg q.d., adjusted based on glycemic control to a 10-mg twice a day maximum dose). Randomization was stratified by: 1) renal status (moderate or severe renal insufficiency); 2) history of cardiovascular disease; and 3) history of heart failure.RESULTSAt week 54, treatment with sitagliptin was noninferior to treatment with glipizide in A1C change from baseline (−0.8 vs. −0.6%; between-group difference −0.11%; 95% CI −0.29 to 0.06) because the upper bound of the 95% CI was less than the prespecified noninferiority margin of 0.4%. There was a lower incidence of symptomatic hypoglycemia adverse events (AEs) with sitagliptin versus glipizide (6.2 and 17.0%, respectively; P = 0.001) and a decrease in body weight with sitagliptin (−0.6 kg) versus an increase (1.2 kg) with glipizide (difference, −1.8 kg; P &lt; 0.001). The incidence of gastrointestinal AEs was low with both treatments.CONCLUSIONSIn patients with T2DM and chronic renal insufficiency, sitagliptin and glipizide provided similar A1C-lowering efficacy. Sitagliptin was generally well-tolerated, with a lower risk of hypoglycemia and weight loss versus weight gain, relative to glipizide.
Mini-Open Sinus Tarsi Approach with Percutaneous Screw Fixation of Displaced Calcaneal Fractures: A Prospective Computed Tomography–Based Study
Authors: Nosewicz Tomasz , Knupp Markus , Barg Alexej , Maas Mario , Bolliger Lilianna , Goslings J. Carel , Hintermann Beat 
Published: December 2012

Background: Open reduction and internal fixation (ORIF) of calcaneal fractures using an extended lateral approach results in soft tissue disruption and theoretically subtalar joint stiffness. A minimally invasive sinus tarsi approach for posterior facet exposure and percutaneous screw fixation of the calcaneal body has been implemented. This report details the reduction and stability of the internal fixation resulting from this approach. Methods: Twenty-one consecutive patients (18 male, 3 female, 45 ± 16 years) with 22 calcaneal fractures underwent ORIF with minimal exposure through the sinus tarsi for reduction, lateral plate fixation, and percutaneous screw fixation. There were nine Sanders type II fractures and 13 type III fractures. Sixteen fractures had calcaneocuboid joint involvement. Nineteen patients (19 fractures) were available for follow-up (mean, 32 ± 14 months). Two computed tomography scans were obtained on each patient, one immediately postoperatively and one after a minimum of 1 year, to evaluate reduction and fixation stability, respectively. The posterior facet and calcaneocuboid joint were graded excellent, good, fair, or poor, according to articular step, defect, and angulation. Any change was considered loss of stability. Similarly, on a conventional two-dimensional radiograph, more than 5 of Bohler's angle difference was defined as loss of calcaneal height. Results: Postoperative posterior facet and calcaneocuboid joint reduction was good (step < 1 mm, defect < 5 mm, angulation < 5) or excellent (no step, defect, angulation) in 14/22 (64%) and 11/16 fractures, respectively. At follow-up, no loss of reduction at the posterior facet and calcaneocuboid joint was noted. More than 5 of Bohler's angle decrease was found in three patients. Conclusion: Even complex calcaneal fractures can be sufficiently exposed by a minimally invasive sinus tarsi approach for anatomic reduction and stable fixation. Most patients had good or excellent functional results, which may have resulted from minimal soft tissue disruption. Level of Evidence: IV, Case Series
Union Rate of Tibiotalocalcaneal Nails with Internal or External Bone Stimulation
Authors: DeVries J. George , Berlet Gregory C. , Hyer Christopher F. 
Published: December 2012

Introduction: The use of bone growth stimulation has been reported in the application of hindfoot and ankle arthrodesis. Most studies have been retrospective case series with few patients. The authors present a comparative analysis of patients undergoing tibiotalocalcaneal (TTC) arthrodesis via a retrograde intramedullary arthrodesis nail to evaluate the influence of internal versus external bone stimulation in this population. Methods: One hundred fifty-four patients were treated with retrograde intramedullary nailing. A comprehensive chart and radiographic review was performed from a database of patients who underwent TTC fusion with or without bone stimulation. Ninety-one patients with retrograde TTC nailing were treated with direct current internal bone stimulation at the time of the index procedure (internal group) and 63 were treated with combined magnetic field external bone stimulation (external group). The primary end point was fusion with potential variables evaluated for influence on fusion rates. Results: Demographically the cohorts were similar groups in age and comorbidities. Surgical and outcome data were examined, and there were few statistically significant differences between the two groups. There was no statistically significant difference in rate of union (52.7% and 57.1%, p = .63) or rate of complications between the internal and external groups. Overall, the success rate for achieving a stable, functional limb for the groups was 81.3% (74/91 patients) and 82.5% (52/63 patients) in the internal and external groups, respectively ( p = .62). Conclusion: The authors demonstrated there were no statistically significant differences between the union and complication rate when comparing these types of internal and external bone stimulation in this patient population. Consideration of these results may help guide physicians when considering bone stimulation as an adjunct to TTC fusions with a retrograde intramedullary nail. Level of Evidence: III
Des actions concertées pour des « gangs de rue » ou des « gangs de rue » pour des actions concertées ?
Authors: Cauchie Jean-François , Corriveau Patrice 
Published: December 2012

À la suite de plusieurs rencontres professionnelles entre chercheurs et membres d’une Table de concertation sur les gangs à Gatineau, il est apparu que les divers partenaires à cette action concertée (service de police, organismes communautaires, hôpitaux, commissions scolaires) éprouvaient beaucoup de difficultés à saisir sur quoi ils travaillaient, à identifier les objectifs qu’ils poursuivaient mais aussi à comprendre qui ils étaient collectivement. Si des repositionnements professionnels et identitaires sont inévitables dans toute action concertée, un dispositif de recherche essentiellement basé sur la méthode d’analyse en groupe (MAG) a mis en évidence que dans le cas étudié, les malaises ressentis avaient surtout trait au fait que les organismes et les acteurs qui les représentent devaient vivre avec un mandat flou qui apparait par défaut. Ce n’était pas tant la présence d’une action concertée sur des « problématiques jeunesse » qui était mise en question que le fait de devoir passer par la case « gangs de rue » pour justifier cette action. Une question se pose donc : est-on dans un scénario où c’est l’action concertée qui répond à une problématique « gang » ou dans un cas de figure où c’est la problématique « gang » qui s’impose comme la meilleure justification de l’action concertée ?
Coactivator-Associated Arginine Methyltransferase 1 Regulates Fetal Hematopoiesis and Thymocyte Development
Authors: Li Jia , Zhao Ziqin , Carter Carla , Ehrlich Lauren I. R. , Bedford Mark T. , Richie Ellen R. 
Published: December 2012

Abstract
Coactivator-associated arginine methyltransferase 1 (CARM1) is a protein arginine methyltransferase that methylates histones and transcriptional regulators. We previously reported that the absence of CARM1 partially blocks thymocyte differentiation at embryonic day 18.5 (E18.5). In this study, we find that reduced thymopoiesis in Carm1−/− mice is due to a defect in the fetal hematopoietic compartment rather than in the thymic stroma. To determine the cellular basis for impaired thymopoiesis, we examined the number and function of fetal liver (FL) and bone marrow cells. Despite markedly reduced cellularity of hematopoietic progenitors in E18.5 bone marrow, the number of long-term hematopoietic stem cells and downstream subsets was not reduced in Carm1−/− E14.5 or E18.5 FL. Nevertheless, competitive reconstitution assays revealed a deficit in the ability of Carm1−/− FL cells to contribute to hematopoiesis. Furthermore, impaired differentiation of Carm1−/− FL cells in a CARM1-sufficient host showed that CARM1 is required cell autonomously in hematopoietic cells. Coculture of Carm1−/− FL cells on OP9-DL1 monolayers showed that CARM1 is required for survival of hematopoietic progenitors under conditions that promote differentiation. Taken together, this report demonstrates that CARM1 is a key epigenetic regulator of hematopoiesis that affects multiple lineages at various stages of differentiation.
Balance between NF-κB p100 and p52 Regulates T Cell Costimulation Dependence
Authors: Giardino Torchia Maria Letizia , Conze Dietrich B. , Jankovic Dragana , Ashwell Jonathan D. 
Published: December 2012

Abstract
c-IAP1 and c-IAP2 are ubiquitin protein ligases (E3s) that repress noncanonical NF-κB activation. We have created mice that bear a mutation in c-IAP2 that inactivates its E3 activity and interferes, in a dominant-negative fashion, with c-IAP1 E3 activity (c-IAP2H570A). The immune response of these animals was explored by infecting them with the Th1-inducing parasite Toxoplasma gondii. Surprisingly, c-IAP2H570A mice succumbed because of T cell production of high levels of proinflammatory cytokines. Unlike naive wild-type (WT) cells, which require signals generated by the TCR and costimulatory receptors to become fully activated, naive c-IAP2H570A T cells proliferated and produced high levels of IL-2 and IFN-γ to stimulation via TCR alone. c-IAP2H570A T cells had constitutive noncanonical NF-κB activation, and IκB kinase inhibition reduced their proliferation to anti-TCR alone to WT levels but had no effect when costimulation via CD28 was provided. Notably, T cells from nfkb2−/− mice, which cannot generate the p52 component of noncanonical NF-κB, were also costimulation independent, consistent with the negative role of this unprocessed protein in canonical NF-κB activation. Whereas T cells from nfkb2+/− mice behaved like WT, coexpression of a single copy of c-IAP2H570A resulted in cleavage of p100, upregulation of p52, and T cell costimulation independence. Thus, p100 represses and p52 promotes costimulation, and the ratio regulates T cell dependence on costimulatory signals.
Risk Factors to Develop Ocular Surface Disease in Treated Glaucoma or Ocular Hypertension Patients
Authors: Rossi Gemma Caterina Maria , Pasinetti Gian Maria , Scudeller Luigia , Raimondi Marta , Lanteri Sara , Bianchi Paolo Emilio 
Published: December 2012

Purpose To identify risk factors for developing ocular surface disease (OSD), to verify the prevalence of OSD, and to record efficacy of questionnaires in identifying symptoms' impact on patients' quality of life. Methods This was an observational, cross-sectional study of patients with topically treated glaucoma. Tear film break-up time (TFBUT) and punctate keratitis were evaluated; 2 quality-of-life questionnaires (National Eye Institute–Visual Function Questionnaire 25 and Glaucoma Symptom Scale) were submitted to all patients. Class of previous and current intraocular pressure (IOP)–lowering drugs, number of drugs, number of drops/day, and total and current benzalkonium chloride (BAK) exposure were collected. Results A total of 233 patients completed the study. TFBUT was abnormal in 71 (30.5%) eyes; punctate keratitis was present in 74 (31.7%). Keratitis was more frequent with increasing number of eyedrops (p=0.008) and number of instillations per day (p=0.009). Ocular surface disease was present in 97 (41.6%) patients and was statistically related to number of medications used (p=0.026). The univariate analysis pointed out that patients with OSD were older (p=0.04), had lower IOP values (p=0.03), were topically treated for more time (p<0.0001), had assumed more BAK (p<0.0001), and presented worst quality of life (p<0.01). The multivariate analysis found that OSD was related to number of medications used (p=0.002), prolonged use of preserved medications (p=0.005), and total BAK exposure (p<0.001). Conclusions There is clinical evidence that the number of medications, their prolonged use, and the total BAK exposure are risk factors to develop OSD in patients with glaucoma. To prevent OSD onset, BAK exposure and the number of topical medications should be reduced.
Comparison of Anatomic and Functional Results after Retinotomy for Retinal Detachment in Pediatric and Adult Patients
Authors: Stopa Marcin , Kocięcki Jarosław , Rakowicz Piotr , Gotz-Więckowska Anna , Rogulska Monika 
Published: December 2012

Purpose We investigated characteristics and treatment outcomes of pediatric vs adult retinal detachment managed by retinotomy and retinectomy. Methods This was a retrospective, nonrandomized, interventional study involving 20 pediatric patients and 25 adult patients operated with vitrectomy and retinectomy due to retinal detachment. Outcome measures included preoperative and postoperative visual acuity at 6 months and at final visit, postoperative proliferative vitreoretinopathy silicone oil removal, final intraocular pressure (IOP), and final anatomic success, defined as complete retinal reattachment. Results Reattachment was observed in 60% (12/20) of pediatric patients and 88% (22/25) of adults at final visit (p=0.041). Statistically significant improvement in visual acuity was observed in adults (p<0.001) but not in children (p=0.360) due to large proportion of anatomic failure. Children required a higher number of further reoperations (p=0.008). Postoperative proliferative vitreoretinopathy was significantly more frequent in pediatric eyes (p=0.003). Conclusions The clinical features and prognosis for pediatric retinotomies and retinectomies are different from those for adults. When a decision to perform retinotomy in children is made, we can anticipate significantly lower anatomic success than in adults. Even though the overall visual acuity was worse in children than in adults, 25% of pediatric eyes achieved 5/50 or better vision.
Recurrent Central Serous Chorioretinopathy after Peripheral Retinal Laser Photocoagulation: A Case Report
Authors: Semeraro Francesco , Russo Andrea , Delcassi Luisa , Costagliola Ciro 
Published: December 2012

Purpose. To report a case of recurrent central serous chorioretinopathy (CSC) after performing peripheral laser photocoagulation for retinal degenerations. Methods. A 44-year-old woman with ocular history of CSC presented to the emergency room of our department complaining of heavy photopsia due to retinal tuft and lattice degenerations, and underwent laser photocoagulation to prevent retinal detachment. Results. Two days after laser treatment, the visual acuity dropped, and optical coherence tomography scan showed the onset of CSC. The serous detachment completely resolved in 20 days with no therapy. A new CSC episode occurred in the same eye after another analogous laser treatment and, similarly, quickly resolved spontaneously. Conclusions. We reviewed the literature and discuss the possibility that laser-induced inflammation could rouse an inflammatory cascade mediated by proinflammatory cytokines and PAI-1, leading to the exacerbation of retinal serous detachment in susceptible patients.
Influence of Co-Monomer Ratio on the Chemical Properties and Cytotoxicity of Poly[Acrylonitrile-Co-(N-Vinylpyrrolidone)] Nanoparticles
Authors: Li Wenzhong , Pierce Benjamin Franklin , Scharnagl Nico , Wischke Christian , Sisson Adam Lee , Lendlein Andreas 
Published: December 2012

Purpose A system of nanoparticles with varying hydrophilicities may include promising biomaterial candidates as they offer various cellular uptake properties and a range of drug encapsulation efficacies, which would be advantageous in regenerative therapies. Therefore, a model system of nanoparticles with varying hydrophilicities was synthesized and assessed for its candidacy as a biomaterial. Methods Here, acrylonitrile (AN) was copolymerized with N-vinylpyrrolidone (NVP) in a mini-emulsion to form a family of nanoparticles, thereby enabling the systematic variation of the copolymer hydrophilicity. The nanoparticles based on these copolymers were prepared and characterized using 1H-NMR, dynamic light scattering, differential scanning calorimetry, and thermal gravimetric analysis. Finally, the cytotoxicity of the nanoparticles was assessed by conducting indirect tests using L929 fibroblasts. Results The nanoparticles showed well controlled NVP/AN molar ratios as determined by 1H NMR, well defined diameters ranging from approximately 100 nm to 200 nm, and increasing glass transition temperatures with increasing molar NVP content. Finally, L929 fibroblasts only slightly changed their morphology upon incubation with material eluates. Conclusions Poly[acrylonitrile-co-(N-vinylpyrrolidone)] nanoparticles with varying amounts of NVP were shown to be a promising model system for further biological assessment.
Writing Assessment in the Humanities:
Authors: Barrett Jason M. 
Published: December 2012

Abstract
This article examines methodological and institutional challenges for empirically measuring student performance on writing. Writing's intrinsic subjectivity and the great variety of writing formats appropriate to diverse contexts raise fundamental questions about the empirical bias of the assessment culture taking root in U.S. higher education. At the same time, the academic training of humanist scholars, who typically have primary responsibility for writing pedagogy in universities, may predispose them to skepticism about assessment culture's broader mission. This article narrates the process by which the Humanities Department at Lawrence Technological University implemented a writing assessment process designed to address these challenges and evaluates the data generated by this process.
The Eyes and Ears of Engagement:
Authors: Naser Curtis R. , Donoghue Karen , Burrell Stephanie 
Published: December 2012

Abstract
This article analyzes the effectiveness of an effort to assess the extent of student engagement at Fairfield University through the assistance of resident assistants (RAs) and the adaptation of a methodology used by the university's schools of engineering and education. Asking RAs to participate in an assessment of their residents provides several clear benefits: the assessment rubric sets clear expectations in plain language; the rubric sets out clear expectations to the residents; and the assessment data appear to be a valid indicator of student engagement and allow the institution to identify students who may benefit from additional counseling or attention.