bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computed tomography and magnetic resonance imaging findings of inflammatory myofibroblastic tumors of the head and neck
Authors: Gao Fei , Zhong Rui , Li Guo-hong , Zhang Wei-dong 
Published: August 2013

Background Inflammatory myofibroblastic tumor (IMT) is a rare tumor of mesenchymal origin that commonly occurs in the lung. Because of its non-specific clinical and imaging features, IMT is often misdiagnosed as a malignant tumor. There have been few imaging reports on IMT of the head and neck. Purpose To analyze the computed tomography (CT) and magnetic resonance imaging (MRI) findings of inflammatory myofibroblastic tumors (IMTs) of the head and neck. Material and Methods Six patients with IMTs of the head and neck confirmed by histopathologic examination were analyzed retrospectively. Results The mean patient age was 40 years. The tumor locations in the six patients were as follows: left bridge of the nose (one), right infratemporal fossa (two), and left parotid gland (three). Three patients who underwent CT all had soft tissue masses or nodules and no calcification. Bridge of the nose tumor showed a homogeneous isodense nodule and mild homogeneous enhancement. Infratemporal fossa tumor showed a homogeneous low density mass and intermediate homogeneous enhancement. Left parotid gland tumor showed a heterogeneous, mostly low density mass, and intermediate heterogeneous enhancement. T1-weighted images of the parotid gland tumors were hypointense; the infratemporal fossa tumor was isointense. T2-weighted images were mildly hypointense and of mixed hypo- and isointensity in the two parotid gland tumors; the infratemporal fossa tumor was homogeneously mildly hypointense. Heterogeneous intermediate enhancement was demonstrated in one parotid gland and the infratemporal fossa patients and mild homogeneous enhancement in another parotid gland patient. Conclusion The imaging features of IMTs of the head and neck are non-specific. An ill-defined, aggressive mass and variable enhancement on CT and MRI may suggest the diagnosis of IMT. IMT should be included in the differential diagnosis of regional tumors.
White matter atrophy in brain of neuromyelitis optica: a voxel-based morphometry study
Authors: Duan Yunyun , Liu Yaou , Liang Peipeng , Jia Xiuqin , Ye Jing , Dong Huiqing , Li Kuncheng 
Published: August 2013

Background Recent studies have shown that tissue damage in neuromyelitis optica (NMO) is not limited to the spinal cord and optic nerve but can also appear in the brain. Previous magnetic resonance imaging (MRI) studies have reported controversial findings regarding the presence of white matter atrophy in NMO patients. Purpose To investigate regional white matter changes in NMO using voxel-based morphometry (VBM). Material and Methods Conventional MRI and T1-weighted three-dimensional MRI were performed on 20 patients with NMO and 20 age- and sex-matched normal controls (NCs). The data were analyzed by statistical parametric mapping 5 (SPM5) to generate white matter concentration maps, and regional white matter concentrations were compared between the two groups. Relationships between the white matter concentration in regions with significant group differences and the Expanded Disability Status Scale (EDSS) and disease duration were further explored. Results Compared to NCs, NMO patients had decreased white matter volumes in the right precentral gyrus, right postcentral gyrus, left middle and medial frontal gyrus, right superior frontal gyrus, bilateral inferior and superior parietal lobule, right angular gyrus, right middle occipital gyrus, and left precuneus. No significant correlation was found between white matter regions with volume reduction and the EDSS and disease duration in NMO. Conclusion We found white matter atrophy in several brain regions in the frontal, parietal, and occipital lobes in NMO, suggesting that subtle white matter damage relevant to the motor, vision, and cognition systems exists in NMO patients. The pattern of white matter atrophy in NMO is different from that in multiple sclerosis (MS).
Lateral Talar Station
Authors: Veljkovic Andrea , Norton Adam , Salat Peter , Saltzman Charles , Femino John , Phisitkul Phinit , Amendola Annunziato 
Published: August 2013

Background: The sagittal relationship of the talus to the tibial shaft can prove invaluable to the orthopedist in understanding and effectively treating ankle pathologies such as ligamentous laxity and ankle arthritis. Any useful radiographic analysis tool to assess the lateral position of the talus must be employable reliably in the clinical setting. Previously published measurements to assess the lateral translational relationship of the talus relative to the tibial axis may not be available in the clinical setting or may be subject to significant inaccuracies. We have defined a sagittal talar position measurement (lateral talar station; LTS), which we postulated could be used reproducibly on clinical radiographs by the orthopedist to define the position of the talus as it relates to the anatomic tibial axis. In addition, we defined the normal range of the LTS measurement. Methods: A retrospective cohort of patients (121 ankles, 104 patients) who presented to our clinic with foot pain between 2005 and 2011 was evaluated for inclusion in the study. Exclusion criteria included patients with ankle trauma, instability, prior ankle surgery, or radiographic evidence of ankle osteoarthrosis. The final cohort consisted of 82 ankles. The LTS was measured digitally for each subject on weight-bearing lateral ankle radiographs by 3 observers. The mean LTS and standard deviation was determined for the entire cohort. In addition, as a means of validating our methodology, we performed an assessment of interobserver and intraobserver reliability in terms of the LTS measurements. Results: The LTS measurements for the entire cohort fit a Gaussian distribution with a mean of 1.17 mm (SD = 0.9893 mm). Interobserver intraclass coefficients for 2 observers (medical student and radiologist) and intraobserver intraclass coefficients for 1 reader (orthopaedic surgeon) indicated excellent reliability, being above 0.9. Conclusion: The LTS was a reliable measure that could be used on weight-bearing lateral ankle radiographs to define sagittal position of the talus in a clinical setting. The normal distribution for the LTS was described in our study population. Level of Evidence: Level IV, case series.
Antidepressant drugs as a complementary therapeutic strategy in cancer
Authors: Bielecka Anna M , Obuchowicz Ewa 
Published: August 2013

In the last decade, it has been increasingly recognized that antidepressant drugs may exert a range of effects, in addition to their well-documented ability to modulate neurotransmission. Although as a group they act on monoaminergic systems and receptors in different ways, a number of studies have demonstrated that at least some antidepressants might have other properties in common, including immunomodulatory, cyto/neuroprotective, analgesic and anti-inflammatory activities. These properties are partly related to the influence of antidepressants on glial cell function.Recently, emerging information about the possible anticancer properties of antidepressants has sparked increased interest within scientific community, and there is now evidence that these drugs affect the key cellular mechanisms of carcinogenesis. This review examines the putative cellular targets for the anticancer action of antidepressant drugs, and presents examples of the interaction between antidepressants and anticancer drugs. By reviewing the current state of research in this area, we hope to focus the attention of oncologists and researchers engaged in the study of cancer on the role that antidepressant drugs could play in the complementary therapy of cancer.
Sample size formulae for the Bayesian continual reassessment method
Authors: Kuen Cheung Ying 
Published: August 2013

Background In the planning of a dose finding study, a primary design objective is to maintain high accuracy in terms of the probability of selecting the maximum tolerated dose. While numerous dose finding methods have been proposed in the literature, concrete guidance on sample size determination is lacking. Purpose With a motivation to provide quick and easy calculations during trial planning, we present closed form formulae for sample size determination associated with the use of the Bayesian continual reassessment method (CRM). Methods We examine the sampling distribution of a nonparametric optimal design and exploit it as a proxy to empirically derive an accuracy index of the CRM using linear regression. Results We apply the formulae to determine the sample size of a phase I trial of PTEN-long in pancreatic cancer patients and demonstrate that the formulae give results very similar to simulation. The formulae are implemented by an R function ‘getn’ in the package ‘dfcrm’. Limitations The results are developed for the Bayesian CRM and should be validated by simulation when used for other dose finding methods. Conclusions The analytical formulae we propose give quick and accurate approximation of the required sample size for the CRM. The approach used to derive the formulae can be applied to obtain sample size formulae for other dose finding methods.
A Clinical and Radiological Study of Peroneal Tendon Pathology
Authors: Giza Eric , Mak Walter , Wong Stephanie E. , Roper Glade , Campanelli Valentina , Hunter John C. 
Published: August 2013

Background. The proportion of patients with clinical findings referable to peroneal pathology and magnetic resonance imaging (MRI)–diagnosed peroneal tendon pathology is unknown. Previous studies have correlated surgical findings with clinical data and preoperative MRI, but there are no published studies that reference clinical examination findings to imaging findings. Purpose. To determine the relationship between peroneal tendon pathology as diagnosed by MRI and clinical findings of peroneal tendon pathology. Methods. Fifty-six patients who had both MRI evidence of peroneal tendon pathology and an associated clinical examination of the ankle were evaluated over a 3-year period at a tertiary care institution. Clinical examination criteria included lateral ankle tenderness, dislocation/snapping, and lateral ankle pain. A board-certified, fellowship-trained musculoskeletal radiologist confirmed the presence of MRI findings consistent with peroneal tendon pathology. Results. Of the 56 patients with positive findings on MRI, 27 patients had an associated positive clinical exam and 29 patients had a negative clinical exam. The positive predictive value of MRI for peroneal tendon tears with positive clinical findings was 48% (95% confidence interval = 35% to 61%). Conclusion. Patients with MRI findings of peroneal tendon pathology should undergo careful clinical examination, as the positive predictive value of MRI for peroneal tendon pathology with actual clinical findings is low. This study demonstrates that peroneal tendon tears are often incidental findings on MRI. Levels of Evidence: Diagnostic, Level III
Multiple Tendon Ruptures of Unknown Etiology
Authors: Axibal Derek P. , Anderson John G. 
Published: August 2013

Tendon ruptures are common findings in foot and ankle practice. The etiology of tendon ruptures tends to be multifactorial—usually due to a combination of trauma, effects of systemic diseases, adverse effects of medications, and obesity. We present an unusual case of right Achilles tendinitis, left Achilles tendon rupture, bilateral peroneus longus tendon rupture, and left peroneus brevis tendon rupture of unknown etiology. This case report highlights the need for research for other possible, lesser known etiologies of tendon pathology. Level of Evidence: Therapeutic, Level IV, Case Study
Predictors of Mortality among Tuberculosis/HIV-Coinfected Persons in Southwest Ethiopia
Authors: Deribe Kebede , Yami Alemeshet , Deribew Amare , Mesfin Nebiyu , Colebunders Robert , Van geertruyden Jean Pierre , Woldie Mirkuzie , Maja Todd 
Published: August 2013

Background: Tuberculosis (TB) remains the most common cause of death in people living with HIV/AIDS. The aim of the present study was to identify predictors of mortality in TB/HIV-coinfected patients. Methods: We conducted an unmatched case–control study among a cohort of TB/HIV-coinfected adults who were on antiretroviral therapy (ART). Cases comprised 69 TB/HIV-coinfected patients who died during this period. For each case, we selected 3 (207) TB/HIV-coinfected patients who were alive during the end of the follow-up period. Results: Male sex (odds ratio [OR] = 2.04, 95% confidence interval [CI]: 1.04-4.02), being bedridden at enrollment (OR = 2.84, 95% CI: 1.17-6.89), and cough of more than 2 weeks during initiation of ART (OR = 4.75 95% CI: 2.14-10.56) were the best predictors of mortality among TB/HIV-coinfected patients. Conclusion: Mortality among TB/HIV-coinfected patients accounted for a considerable number of deaths among the cohort. Patients with cough at ART initiation and with poor functional status should be strictly followed to reduce death.
Anterior Limbus Vertebra and Intervertebral Disk Degeneration in Japanese Collegiate Gymnasts
Authors: Koyama Koji , Nakazato Koichi , Min Seok-Ki , Gushiken Koji , Hatakeda Yoshiaki , Seo Kyoko , Hiranuma Kenji 
Published: August 2013

Background: Magnetic resonance imaging (MRI) studies have shown that gymnasts have a high prevalence of radiological abnormalities, such as intervertebral disk degeneration (IDD) and anterior limbus vertebra (ALV). These 2 abnormalities may coexist at the same spinal level. However, the relationship between IDD and ALV remains unclear. Hypothesis: A significant relationship exists between IDD and ALV in Japanese collegiate gymnasts. Study Design: Case-control study. Methods: A total of 104 Japanese collegiate gymnasts (70 men and 34 women; age, 19.7 ± 1.0 years) with 11.8 ± 3.6 years of sporting experience participated. T1- and T2-weighted MRIs were used to evaluate ALV and IDD. Results: The prevalence among the gymnasts of IDD and ALV was 40.4% (42/104) and 20.2% (21/104), respectively. The prevalence of IDD was significantly higher in gymnasts with ALV than those without ALV, as determined using the chi-square test. Logistic regression analysis demonstrated a significant association between IDD and ALV (adjusted odds ratio [OR], 6.60; 95% confidence interval [CI], 2.14-20.35). IDD was further grouped by whether it was present in the upper lumbar region (L1-2, L2-3, and L3-4 disks) or in the lower lumbar region (L4-5 and L5-S1 disks). Upper IDD had a greater association with ALV (adjusted OR, 33.17; 95% CI, 7.09-155.25) than did lower IDD (adjusted OR, 6.71; 95% CI, 1.57-28.73). Conclusion: In Japanese collegiate gymnasts, ALV is a predictor of IDD, especially in the upper lumbar region. Clinical Relevance: Information regarding ALV is important to prevent IDD in Japanese collegiate gymnasts.
Iliopsoas Syndrome in Dancers
Authors: Laible Catherine , Swanson David , Garofolo Garret , Rose Donald J. 
Published: August 2013

Background: Coxa saltans refers to a constellation of diagnoses that cause snapping of the hip and is a major cause of anterior hip pain in dancers. When the internal type is accompanied by weakness or pain, it is referred to as iliopsoas syndrome. Iliopsoas syndrome is the result of repetitive active hip flexion in abduction and can be confused with other hip pathology, most commonly of labral etiology. Purpose: To report the incidence, clinical findings, treatment protocol, and results of treatment for iliopsoas syndrome in a population of dancers. Study Design: Retrospective case series; Level of evidence, 4. Methods: A retrospective database review of 653 consecutive patients evaluated for musculoskeletal complaints over a 3-year period was completed. The diagnosis of iliopsoas syndrome was made based on anterior hip or groin pain, weakness with resisted hip flexion in abduction, or symptomatic clicking or snapping with a positive iliopsoas test. Patients identified with iliopsoas syndrome were further stratified according to age at time of onset, insidious versus acute onset, duration of symptoms, side of injury, presence of rest pain, pain with activities of daily living, and associated lower back pain. All patients diagnosed with iliopsoas syndrome underwent physical therapy, including hip flexor stretching and strengthening, pelvic mobilization, and modification of dance technique or exposure as required. Results: A total of 49 dancers were diagnosed and treated for iliopsoas syndrome. Within this injured population of 653 patients, the incidence in female dancers was 9.2%, significantly higher than that in male dancers (3.2%). The mean age at the time of injury was 24.6 years. The incidence of iliopsoas syndrome in dancers younger than 18 years was 12.8%, compared with 7% in dancers older than 18 years. Student dancers had the highest incidence (14%), followed by amateur dancers (7.5%), while professional dancers had the lowest incidence (4.6%). All patients responded to conservative treatment, and no patients required corticosteroid injections or surgical intervention. Conclusion: This is the largest series reported to date of iliopsoas syndrome in the dance population, treated noninvasively. This study supports that conservative treatment with nonsteroidal anti-inflammatory medication, activity modification, and a physical therapy regimen specific to the iliopsoas should be the primary treatment for patients with iliopsoas syndrome. Clinical Relevance: This study supports current literature and conservative treatment of iliopsoas syndrome diagnosis. Furthermore, this study gives specific information regarding incidence of iliopsoas syndrome in dance populations and provides a test for diagnosis and an algorithm for treatment.
Švenekite, Ca[AsO2(OH)2]2, a new mineral from Jáchymov, Czech Republic
Authors: Ondruš P. , Skála R. , Plášil J. , Sejkora J. , Veselovský F. , Čejka J. , Kallistová A. , Hloušek J. , Fejfarová K. , Škoda R. , Dušek M. , Gabašová A. , Machovič V. , Lapčák L. 
Published: August 2013

AbstractŠvenekite (IMA 99-007), Ca[AsO2(OH)2]2, is a rare supergene arsenate mineral occurring in the Geschieber vein, Jáchymov ore district, Western Bohemia, Czech Republic. It grows directly on the granite rocks and occurs isolated from other arsenate minerals otherwise common in Jáchymov. Švenekite usually forms clear transparent coatings composed of indistinct radiating to rosette-shaped aggregates up to 3 mm across. They are composed of thin lens- or bladed-shaped crystals, usually 100 – 150 μm long. Švenekite is transparent to translucent and has a white streak and a vitreous lustre; it does not fluoresce under ultraviolet light. Cleavage is very good on {010}. The Mohs hardness is ∼2. Švenekite is biaxial, non-pleochroic. The refractive indices are α' = 1.602(2), γ' = 1.658(2). The empirical formula of švenekite (based on As + P + S = 2 a.p.f.u., an average of 10 spot analyses) is (Ca1.00Mg0.01)Σ1.01[AsO2(OH)2]1.96[PO2(OH)2]0.03(SO4)0.01. The simplified formula is Ca[AsO2(OH)2]2 and requires CaO 17.42, As2O571.39, H2O 11.19, total 100.00 wt.%. Raman and infrared spectroscopy exhibit dominance of O – H vibrations and vibration modes of distorted tetrahedral AsO2(OH)2 units. Švenekite is triclinic, space group P, with a = 8.5606(5), b = 7.6926(6), c = 5.7206(4) Å, α = 92.605(6), β = 109.9002(6), γ = 109.9017(6)º, and V = 327.48(4) Å3, Z = 2, Dcalc = 3.26 g·cm–3. The a:b:c ratio is 0.7436:1:1.1082 (for single-crystal data). The six strongest diffraction peaks in the X-ray powder diffraction pattern are [d (Å)/I(%)/(hkl)]: 3.968(33)(20); 3.766(35)(2); 3.697(49)(101); 3.554(100)(020); 3.259(33)(20); 3.097(49)(11). The crystal structure of švenekite was refined from single-crystal X-ray diffraction data to R1 = 0.0250 based on 1309 unique observed, and to wR2 = 0.0588, for all 1588 unique reflections (with GOFall = 1.20). The structure of švenekite consists of sheets of corner-sharing CaO8 polyhedra and AsO2 OH2 groups, stacked parallel to (001). Adjacent sheets are linked by hydrogen bonds. The švenekite structure possesses very short symmetrical hydrogen bonds (with the D–H lengths ∼1.22 Å). The mineral is named to honour Jaroslav Švenek, the former curator of the mineralogical collection of the National Museum in Prague, Czech Republic.
The dumortierite supergroup. I. A new nomenclature for the dumortierite and holtite groups
Authors: Pieczka A. , Evans R. J. , Grew E. S. , Groat L. A. , Ma C. , Rossman G. R. 
Published: August 2013

AbstractAlthough the distinction between magnesiodumortieite and dumortierite, i.e. Mg vs. Al dominance at the partially vacant octahedral Al1 site, had met current criteria of the IMA Commission on New Minerals, Nomenclature and Classification (CNMNC) for distinguishing mineral species, the distinction between holtite and dumortierite had not, since Al and Si are dominant over Ta and (Sb, As) at the Al1 and two Si sites, respectively, in both minerals. Recent studies have revealed extensive solid solution between Al, Ti, Ta and Nb at Al1 and between Si, As and Sb at the two Si sites or nearly coincident (As, Sb) sites in dumortierite and holtite, further blurring the distinction between the two minerals.This situation necessitated revision in the nomenclature of the dumortierite group. The newly constituted dumortierite supergroup, space group Pnma (no. 62), comprises two groups and six minerals, one of which is the first member of a potential third group, all isostructural with dumortierite. The supergroup, which has been approved by the CNMNC, is based on more specific end-member compositions for dumortierite and holtite, in which occupancy of the Al1 site is critical.(1) Dumortierite group, with Al1 = Al3+, Mg2+ and ☐, where ☐ denotes cation vacancy. Charge balance is provided by OH substitution for O at the O2, O7 and O10 sites. In addition to dumortierite, endmember composition AlAl6BSi3O18, and magnesiodumortierite, endmember composition MgAl6BSi3O17(OH), plus three endmembers, “hydroxydumortierite”, ☐Al6BSi3O15(OH)3 and two Mg-Ti analogues of dumortierite, (Mg0.5Ti0.5)Al6BSi3O18 and (Mg0.5Ti0.5)Mg2Al4BSi3O16(OH)2, none of which correspond to mineral species. Three more hypothetical endmembers are derived by homovalent substitutions of Fe3+ for Al and Fe2+ for Mg.(2) Holtite group, with Al1 = Ta5+, Nb5+, Ti4+ and ☐. In contrast to the dumortierite group, vacancies serve not only to balance the extra charge introduced by the incorporation of pentavalent and quadrivalent cations for trivalent cations at Al1, but also to reduce repulsion between the highly charged cations. This group includes holtite, endmember composition (Ta0.6☐0.4)Al6BSi3O18, nioboholite (2012-68), endmember composition (Nb0.6☐0.4)Al6BSi3O18, and titanoholtite (2012-69), endmember composition (Ti0.75☐0.25)Al6BSi3O18.(3) Szklaryite (2012-70) with Al1 = ☐ and an endmember formula ☐Al6BAs3+3O15. Vacancies at Al1 are caused by loss of O at O2 and O7, which coordinate the Al1 with the Si sites, due to replacement of Si4+ by As3+ and Sb3+, and thus this mineral does not belong in either the dumortierite or the holtite group. Although szklaryite is distinguished by the mechanism introducing vacancies at the Al1 site, the primary criterion for identifying it is based on occupancy of the Si/As, Sb sites: (As3+ + Sb3+) > Si4+ consistent with the dominant-valency rule. A Sb3+ analogue to szklaryite is possible.
On a geometric equation involving the Sobolev trace critical exponent
Authors: Al-Ghamdi Mohamed Ali , Chtioui Hichem , Sharaf Khadija 
Published: August 2013

Abstract
In this paper we consider the problem of prescribing the mean curvature on the boundary of the unit ball of

R
n

,

n
≥
4

. Under the assumption that the prescribed function is flat near its critical point, we give precise estimates on the losses of the compactness, and we provide a new existence result of Bahri-Coron type. Moreover, we establish, under generic boundary condition, a Morse inequality at infinity, which gives a lower bound on the number of solutions to the above problem.

MSC:58E05, 35J65, 53C21, 35B40.