bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extra-articular ACL Reconstruction and Pivot Shift
Authors: Monaco Edoardo , Maestri Barbara , Conteduca Fabio , Mazza Daniele , Iorio Carlo , Ferretti Andrea 
Published: May 2014

Background: The pivot-shift test is considered a reliable examination to evaluate the results of anterior cruciate ligament (ACL) reconstruction, as it strongly correlates with patient satisfaction, giving-way episodes, and activity level. The addition of lateral tenodesis (LT) to current techniques of intra-articular reconstruction with a hamstring graft could potentially improve knee laxity in cases of severe rotational instability. Purpose: To biomechanically investigate the effect of intra- and extra-articular ACL reconstructions on knee laxity and the pivot-shift phenomenon. Study Design: Controlled laboratory study. Methods: Twenty patients underwent anatomic single-bundle ACL reconstruction with doubled semitendinosus and gracilis tendons with the addition of extra-articular reconstruction. In patients in group A, intra-articular reconstruction was performed first and LT thereafter; in patients in group B, LT was performed first and intra-articular reconstruction thereafter. A navigator equipped with software designed for both static and dynamic evaluations was used to measure maximum anterior tibial translation (ATT) and axial tibial rotation (ATR) at 30° of flexion (static evaluation) and during the pivot-shift test (dynamic evaluation). Measurements were performed before reconstruction, after the first procedure, and after the second procedure. Results: For the static evaluation, in group A, the mean ATT significantly decreased from 14.1 ± 3.7 mm in the preoperative (ACL-deficient) condition to 6.0 ± 1.9 mm after ACL reconstruction and to 5.3 ± 1.6 mm after LT. The mean ATR at 30° of knee flexion significantly decreased from 35.7° ± 4.8° to 28.9° ± 4.1° and to 20.9° ± 4.8°, respectively. In group B, the mean ATT significantly decreased from 13.5 ± 6.5 mm in the preoperative (ACL-deficient) condition to 10.2 ± 3.2 mm after LT and to 4.0 ± 1.6 mm after ACL reconstruction. The mean ATR at 30° of knee flexion significantly decreased from 36.7° ± 4.8° to 26.2° ± 6.2° and to 23.5° ± 4.9°, respectively. For the dynamic evaluation (pivot-shift test), in group A, the mean ATT significantly decreased from 15.0 ± 6.8 mm in the preoperative (ACL-deficient) condition to 9.4 ± 6.4 mm after ACL reconstruction and to 8.5 ± 5.4 mm after LT. The mean ATR significantly decreased from 16.9° ± 4.7° to 11.6° ± 4.1° and to 6.1° ± 2.2°, respectively. In group B, the mean ATT significantly decreased from 12.5 ± 3.3 mm in the preoperative (ACL-deficient) condition to 9.1 ± 5.9 mm after LT and to 8.1 ± 5.4 mm after ACL reconstruction. The mean ATR significantly decreased from 16.0° ± 4.5° to 9.2° ± 4.3° and to 7.5° ± 4.0°, respectively. Conclusion/Clinical Relevance: Extra-articular reconstruction had little effect in reducing the anterior displacement of the tibia at 30° of flexion, but it was more effective than intra-articular reconstruction in reducing ATR. Anatomic ACL reconstruction and LT were synergic in controlling the pivot-shift phenomenon.
Randomized, controlled pilot study comparing large-volume paracentesis using wall suction and traditional glass vacuum bottle methods
Authors: Konerman Monica A. , Price Jennifer , Torres Dawn , Li Zhiping 
Published: May 2014

Objectives: Large-volume paracentesis (LVP) can be time and labor intensive depending on the amount of ascites removed and the method of drainage. Wall suction has been adopted as the preferred method of drainage at many centers, though the safety and benefits of this technique have not been formally evaluated. The primary objective of this study was to define the cost and time savings of wall suction over the traditional glass vacuum bottle method for ascites drainage. The secondary objective was to compare the safety profile and patient satisfaction using these two techniques. Methods: We conducted a randomized, controlled pilot study of the wall suction versus vacuum bottle methods for LVP in hospitalized patients. All LVPs were performed under ultrasound guidance by a single proceduralist. Patients with at least 4 liters removed received 25% intravenous albumin, 8 g/liter fluid removed. Demographic, clinical characteristics, and procedure details were recorded. Laboratory and hemodynamic data were recorded for 24 h prior to and 24–48 h post LVP. An electronic chart review was conducted to evaluate procedure-related complications. Data were compared using Fisher’s exact test, t test, or Mann–Whitney U test. Results: Thirty-four patients were randomized to wall suction at 200 mmHg ( n = 17) or glass vacuum bottle drainage ( n = 17). Wall suction was significantly faster and less costly than vacuum bottle drainage (7 versus 15 min, p = 0.002; $4.59 versus $12.73, p < 0.001). There were no differences in outcomes at 24 and 48 h post LVP, or at 60-day follow up. Conclusion: Performing LVP using wall suction resulted in significantly shorter procedure time and supply cost savings. There were no differences in outcomes between the groups, suggesting equivalent safety, though larger studies powered to detect small differences are needed. Given its efficiency, convenience, and cost effectiveness, wall suction may be a superior method of ascites drainage for LVP.
Online Mental Disability Law Education, a Disability Rights Tribunal and the Creation of an Asian Disability Law Database: Their Impact on Research, Training and Teaching of Law, Criminology and Criminal Justice in Asia
Authors: Perlin Michael L. , Cucolo Heather , Esq Yoshikazu Ikehara 
Published: May 2014

Two professors at New York Law School (NYLS) and the director of the Tokyo Advocacy Law Office are engaged in initiatives with the potential to have major influences on the study of law, criminology and criminal justice: the creation of a Disability Rights Tribunal for Asia and the Pacific (DRTAP) and expansion of NYLS’s online mental disability law programme (OMDLP) to include numerous Asian venues. DRTAP seeks to create a sub-regional body (a Commission and eventually a Court) to hear violations of the UN’s Convention on the Rights of Persons with Disabilities. This will explicitly inspire scholarship about issues such as treatment of forensic patients, relationships between mental disability enforcement and criminal law enforcement, and connections between mental disability and criminal procedure. NYLS’s OMDLP offers thirteen valuable courses to criminologists and criminal justice scholars and will host DRICAP (Disability Rights Information Center for Asia and the Pacific), providing Internet access to important disability rights developments from ten nations in the Asia/Pacific region. This partnership offers unrivalled knowledge in criminal justice and mental disability law. Our article will detail and explain how these programmes train, teach and foster new research, distinctively benefiting Asia’s legal/advocacy/criminology/criminal justice communities.
Valproic acid in combination with all-trans retinoic acid and intensive therapy for acute myeloid leukemia in older patients
Authors: Tassara Michela , Döhner Konstanze , Brossart Peter , Held Gerhard , Götze Katharina , Horst Heinz-A. , Ringhoffer Mark , Köhne Claus-Henning , Kremers Stephan , Raghavachar Aruna , Wulf Gerald , Kirchen Heinz , Nachbaur David , Derigs Hans Günter , Wattad Mohammed , Koller Elisabeth , Brugger Wolfram , Matzdorff Axel , Greil Richard , Heil Gerhard , Paschka Peter , Gaidzik Verena I. , Göttlicher Martin , Döhner Hartmut , Schlenk Richard F. 
Published: May 2014

Key Points
The addition of valproic acid to intensive induction therapy in combination with all-trans retinoic acid did not result in an improvement of clinical outcome. Valproic acid-related hematologic toxicity and higher death rates were observed when valproic acid and idarubicin were given in parallel.
Eltrombopag and high-dose dexamethasone as frontline treatment of newly diagnosed immune thrombocytopenia in adults
Authors: Gómez-Almaguer David , Herrera-Rojas Miguel A. , Jaime-Pérez José C. , Gómez-De León Andrés , Cantú-Rodríguez Olga G. , Gutiérrez-Aguirre César H. , Tarín-Arzaga Luz , Hernández-Reyes Jesús , Ruiz-Arguelles Guillermo J. 
Published: May 2014

Key Points
Eltrombopag/dexamethasone is a safe and effective combination for treating newly diagnosed ITP patients. This treatment may prove useful in achieving lasting responses without additional immunosuppression in some patients.
Pretransplant comorbidities predict severity of acute graft-versus-host disease and subsequent mortality
Authors: Sorror Mohamed L. , Martin Paul J. , Storb Rainer F. , Bhatia Smita , Maziarz Richard T. , Pulsipher Michael A. , Maris Michael B. , Davis Christopher , Deeg H. Joachim , Lee Stephanie J. , Maloney David G. , Sandmaier Brenda M. , Appelbaum Frederick R. , Gooley Theodore A. 
Published: May 2014

Key Points
The HCT-CI stratifies patients into 3 groups for risks of grades 3 to 4 GVHD regardless of conditioning intensity, donor, or graft types. Comorbidity burden and development of grades 2 to 4 acute GVHD have cumulative effects on mortality rates.
Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia
Authors: Pflug Natali , Bahlo Jasmin , Shanafelt Tait D. , Eichhorst Barbara F. , Bergmann Manuela A. , Elter Thomas , Bauer Kathrin , Malchau Gebhart , Rabe Kari G. , Stilgenbauer Stephan , Döhner Hartmut , Jäger Ulrich , Eckart Michael J. , Hopfinger Georg , Busch Raymonde , Fink Anna-Maria , Wendtner Clemens-Martin , Fischer Kirsten , Kay Neil E. , Hallek Michael 
Published: May 2014

Key PointsPrognostic tool for CLL patients with high discriminatory power compared with conventional clinical staging systems. Prognostication on the individual patient level independent of clinical stage.
Epidemiology, species distribution and outcome of nosocomial Candida spp.bloodstream infection in Shanghai
Authors: Yang Zhi-Tao , Wu Lin , Liu Xiao-Ying , Zhou Min , Li Jie , Wu Jia-Yin , Cai Yong , Mao En-Qiang , Chen Er-Zhen , Lortholary Olivier 
Published: May 2014

Abstract

Background
Yeasts, mostly Candida, are important causes of bloodstream infections (BSI), responsible for significant mortality and morbidity among hospitalized patients. The epidemiology and species distribution vary from different regions. The goals of this study were to report the current epidemiology of Candida BSI in a Shanghai Teaching Hospital and estimate the impact of appropriate antifungal therapy on the outcome.

Methods
From January 2008 to December 2012, all consecutive patients who developed Candida BSI at Ruijin University Hospital were enrolled. Underlying diseases, clinical severity, species distribution, antifungal therapy and its impact on the outcome were analyzed.

Results
A total of 121 episodes of Candida BSI were identified, with an incidence of 0.32 episodes/1,000 admissions (0.21 in 2008 and 0.42 in 2012) The proportion of candidemia caused by non-albicans species (62.8%), including C. parapsilosis (19.8%), C. tropicalis (14.9%), C. glabrata (7.4%), C. guilliermondii (5.8%), C. sake (5.0%) was higher than that of candidemia caused by C. albicans (37.2%). The overall crude 28-day mortality was 28.1% and significantly reduced with appropriate empiric antifungal therapy administered within 5 days (P = 0.006). Advanced age (OR 1.04; P = 0.014), neutropenia < 500/mm3 (OR 17.44; P < 0.001) were independent risk factors for 28-day mortality, while appropriate empiric antifungal therapy (OR 0.369; P = 0.035) was protective against 28-day mortality.

Conclusion
The epidemiology of candidemia in Shanghai differed from that observed in Western countries. Appropriate empiric antifungal therapy influenced the short-term survival.
Clinical and optic coherence tomography findings of focal choroidal excavation in Chinese patients
Authors: Guo Jie , Zhong Lu , Jiang Chunhui , Zhou Xin , Xu Gezhi , Wang Wenji , Wang Yuliang 
Published: May 2014

Abstract

Background
To describe the clinical and optical coherence tomography (OCT) features of focal choroidal excavation in Chinese patients.

Methods
Retrospectively, thirty-seven eyes (in 31 patients) that demonstrated focal choroidal excavation on spectral-domain OCT were collected. Their clinical characteristics and other features were also collected and analyzed.

Results
In total, 42 focal choroidal excavations were identified in 31 patients, including 25 unilateral and 6 bilateral (37 eyes). The abnormal changes in these eyes with choroidal excavation were more prominent at the outer part of the neuro-retina, the retinal pigment epithelium (RPE) and the choroid. The average transverse diameter and depth of the excavations were 670.8 μm and 106.9 μm, respectively. In addition to the conforming and nonconforming types, the excavations could also be classified into 2 types according to their shape: type 1 – small with a sharp, cut-down contour; and type 2 – slightly larger with a gradual edge. The transverse diameter/depth ratio of the two types were significantly different (type1: 4.57 ± 1.65, type 2: 10.0 ± 5.2; p = 0.000). Four central serous chorioretinopathy (CSCR) cases were confirmed by fluorescein angiography; in these cases, the retinal detachment was larger than the area of excavation, and the inner segment/outer segment (IS/OS) and external limiting membrane (ELM) were above those of the normal part. Concomitant CNV was also found in another 2 cases.

Conclusions
Focal choroidal excavation was not uncommon in Chinese patients. The choroid and the RPE at the excavation were impaired or vulnerable to other damage. Additionally, OCT might be useful in the differentiation between nonconforming excavations and ones with CSCR.
Existence of an unbounded branch of the set of solutions for Neumann problems involving the "Equation missing" -Laplacian
Authors: Hwang Byung-Hoon , Lee Seung Dae , Kim Yun-Ho 
Published: May 2014

Abstract
We are concerned with the following nonlinear problem:

−
div
(
w
(
x
)

|
∇
u
|

p
(
x
)
−
2

∇
u
)
+

|
u
|

p
(
x
)
−
2

u
=
μ
g
(
x
)

|
u
|

p
(
x
)
−
2

u
+
f
(
λ
,
x
,
u
,
∇
u
)

in Ω,

∂
u

∂
n

=
0

on ∂ Ω, which is subject to a Neumann boundary condition, provided that μ is not an eigenvalue of the

p
(
x
)

-Laplacian. The aim of this paper is to study the structure of the set of solutions for the degenerate

p
(
x
)

-Laplacian Neumann problems by applying a bifurcation result for nonlinear operator equations.

MSC:35B32, 35D30, 35J70, 47J10, 47J15.
The histamine H4 receptor is a potent inhibitor of adhesion-dependent degranulation in human neutrophils
Authors: Dib Karim , Perecko Tomas , Jenei Veronika , McFarlane Cheryl , Comer David , Brown Vanessa , Katebe Mwape , Scheithauer Torsten , Thurmond Robin L , Chazot Paul L , Ennis Madeleine 
Published: May 2014

AbstractThe histamine H4 receptor regulates the inflammatory response. However, it is not known whether this receptor has a functional role in human neutrophils. We found that fMLP (1 μM), but not histamine (0.1–1 μM), induced Mac-1-dependent adhesion, polarization, and degranulation (release of lactoferrin). A pretreatment of neutrophils with histamine (0.001–1 μM) or JNJ 28610244 (0.1–10 μM), a specific H4 receptor agonist, led to inhibition of degranulation. Total inhibition of degranulation was obtained with 0.1 μM histamine and 10 μM JNJ 28610244. Furthermore, such inhibition by histamine of degranulation was reversed by JNJ 7777120 and JNJ 28307474, two selective H4 receptor antagonists. However, neither histamine nor the H4 receptor agonist JNJ 28610244 prevented fMLP-induced, Mac-1-dependent adhesion, indicating that the H4 receptor may block signals emanating from Mac-1-controlling degranulation. Likewise, engagement of the H4 receptor by the selective agonist JNJ 28610244 blocked Mac-1-dependent activation of p38 MAPK, the kinase that controls neutrophil degranulation. We also show expression of the H4 receptor at the mRNA level in ultrapure human neutrophils and myeloid leukemia PLB-985 cells. We concluded that engagement of this receptor by selective H4 receptor agonists may represent a good, therapeutic approach to accelerate resolution of inflammation.
Drug analog inhibition of indoleamine 2,3-dioxygenase (IDO) activity modifies pattern recognition receptor expression and proinflammatory cytokine responses early during influenza virus infection
Authors: Fox Julie M , Sage Leo K , Poore Spencer , Johnson Scott , Tompkins S Mark , Tripp Ralph A 
Published: May 2014

AbstractInfluenza virus is recognized by PRRs, which are critical in the early response to virus infection and induction of proinflammatory cytokines. IDO is increased in the lung of mice immediately following influenza infection, and the presence of IDO has been shown to mediate immune suppression through depletion of trp and reduction in IL-6 production. To determine the role of IDO activity in the early immune response to influenza infection, IDO activity was inhibited using the synthetic analog, 1MT. The results show that IDO inhibition enhanced proinflammatory cytokine gene and protein expression at 24 and 48 h postinfection, respectively, compared with control-treated mice and affected PRR expression. The enhanced proinflammatory response in the presence of 1MT was attributed to macrophages in the airways, as Raw264.7 and primary AMs showed enhanced production of IFN-β, IL-1β, IL-6, and TNF-α in the presence of 1MT. These findings provide important knowledge for the role of IDO during initial host response to influenza infection.
Active Idiotypic Vaccination Versus Control Immunotherapy for Follicular Lymphoma
Authors: Levy Ronald , Ganjoo Kristen N. , Leonard John P. , Vose Julie M. , Flinn Ian W. , Ambinder Richard F. , Connors Joseph M. , Berinstein Neil L. , Belch Andrew R. , Bartlett Nancy L. , Nichols Craig , Emmanouilides Christos E. , Timmerman John M. , Gregory Stephanie A. , Link Brian K. , Inwards David J. , Freedman Arnold S. , Matous Jeffrey V. , Robertson Michael J. , Kunkel Lori A. , Ingolia Diane E. , Gentles Andrew J. , Liu Chih Long , Tibshirani Robert , Alizadeh Ash A. , Denney Dan W. 
Published: May 2014

PurposeIdiotypes (Ids), the unique portions of tumor immunoglobulins, can serve as targets for passive and active immunotherapies for lymphoma. We performed a multicenter, randomized trial comparing a specific vaccine (MyVax), comprising Id chemically coupled to keyhole limpet hemocyanin (KLH) plus granulocyte macrophage colony-stimulating factor (GM-CSF) to a control immunotherapy with KLH plus GM-CSF.Patients and MethodsPatients with previously untreated advanced-stage follicular lymphoma (FL) received eight cycles of chemotherapy with cyclophosphamide, vincristine, and prednisone. Those achieving sustained partial or complete remission (n = 287 [44%]) were randomly assigned at a ratio of 2:1 to receive one injection per month for 7 months of MyVax or control immunotherapy. Anti-Id antibody responses (humoral immune responses [IRs]) were measured before each immunization. The primary end point was progression-free survival (PFS). Secondary end points included IR and time to subsequent antilymphoma therapy.ResultsAt a median follow-up of 58 months, no significant difference was observed in either PFS or time to next therapy between the two arms. In the MyVax group (n = 195), anti-Id IRs were observed in 41% of patients, with a median PFS of 40 months, significantly exceeding the median PFS observed in patients without such Id-induced IRs and in those receiving control immunotherapy.ConclusionThis trial failed to demonstrate clinical benefit of specific immunotherapy. The subset of vaccinated patients mounting specific anti-Id responses had superior outcomes. Whether this reflects a therapeutic benefit or is a marker for more favorable underlying prognosis requires further study.
Predictive Value of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society Classification of Lung Adenocarcinoma in Tumor Recurrence and Patient Survival
Authors: Hung Jung-Jyh , Yeh Yi-Chen , Jeng Wen-Juei , Wu Kou-Juey , Huang Biing-Shiun , Wu Yu-Chung , Chou Teh-Ying , Hsu Wen-Hu 
Published: May 2014

Purpose This study investigated the pattern of recurrence of lung adenocarcinoma and the predictive value of histologic classification in resected lung adenocarcinoma using the new International Association for the Study of Lung Cancer (IASLC)/American Thoracic Society (ATS)/European Respiratory Society (ERS) classification system. Patients and Methods Histologic classification of 573 patients undergoing resection for lung adenocarcinoma was determined according to the IASLC/ATS/ERS classification system, and the percentage of each histologic component (lepidic, acinar, papillary, micropapillary, and solid) was recorded. The pattern of recurrence of those components and their predictive value were investigated. Results The predominant histologic pattern was significantly associated with sex (P < .01), invasive tumor size (P < .01), T status (P < .01), N status (P < .01), TNM stage (P < .01), and visceral pleural invasion (P < .01). The percentage of recurrence was significantly higher in micropapillary- and solid-predominant adenocarcinomas (P < .01). Micropapillary- and solid-predominant adenocarcinomas had a significantly higher possibility of developing initial extrathoracic-only recurrence than other types (P < .01). The predominant pattern group (micropapillary or solid v lepidic, acinar, or papillary) was a significant prognostic factor in overall survival (OS; P < .01), probability of freedom from recurrence (P < .01), and disease-specific survival (P < .01) in multivariable analysis. For patients receiving adjuvant chemotherapy, solid-predominant adenocarcinoma was a significant predictor for poor OS (P = .04). Conclusion In lung adenocarcinoma, the IASLC/ATS/ERS classification system has significant prognostic and predictive value regarding death and recurrence. Solid-predominant adenocarcinoma was also a significant predictor in patients undergoing adjuvant chemotherapy. Prognostic and predictive information is important for stratifying patients for aggressive adjuvant chemoradiotherapy.
Patient Education, Coaching, and Self-Management for Cancer Pain
Authors: Lovell Melanie R. , Luckett Tim , Boyle Frances M. , Phillips Jane , Agar Meera , Davidson Patricia M. 
Published: May 2014

Purpose Multiple systematic reviews and meta-analyses have identified the effectiveness of patient education in improving cancer pain management. However, the mechanisms by which patient education improves pain outcomes are uncertain, as are the optimal delivery, content, timing, frequency, and duration. This review provides best-bet recommendations based on available evidence to guide service managers and clinicians in developing a patient education program. Methods We used patient-centered care, self-management, coaching, and a behavior change wheel as lenses through which to consider the evidence for elements of patient education most likely to be effective within the context of other strategies for overcoming barriers to cancer pain assessment and management. Results The evidence suggests that optimal strategies include those that are patient-centered and tailored to individual needs, are embedded within health professional–patient communication and therapeutic relationships, empower patients to self-manage and coordinate their care, and are routinely integrated into standard cancer care. An approach that integrates patient education with processes and systems to ensure implementation of key standards for pain assessment and management and education of health professionals has been shown to be most effective. Conclusion Patient education is effective in reducing cancer pain and should be standard practice in all settings. For optimal results, patient education should be integrated with other strategies for implementing evidence-based, person-centered care and overcoming barriers at the levels of patient, provider, and health system.