bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Design Applied for Cost and Efficiency of Antioxidants in Biodiesel
Authors: Orives Juliane Resges , Galvan Diego , Pereira Jaqueline Laís , Coppo Rodolfo Lopes , Borsato Dionísio 
Published: August 2014

AbstractOxidation stability is a parameter of great importance for biodiesel quality control to both producers and subsequent consumers. To maintain the quality of biodiesel, currently the most effective and economical method is the addition of antioxidants that prevent or retard the biofuel oxidation reaction. In this study, efficiency and cost of synthetic antioxidants added to B100 biodiesel from soybean oil and pork fat were evaluated, using butylhydroxyanisole (BHA), butylhydroxytoluene (BHT) and tert‐butylhydroquinone (TBHQ), in pure form or in mixtures, according to a simplex‐centroid mixture experimental design. Results demonstrate an increased induction period (IP) in all trials when compared to the control sample, and TBHQ was the only antioxidant alone that met all the specification standards, while BHT and BHA alone met only the American standard specifications. The antioxidant mixture that presented the highest synergistic effect was that of TBHQ and BHA. Multi‐response optimization indicated an optimum formulation containing 75 % TBHQ and 25 % BHA with an IP of 7.27 h at 110 °C and the antioxidant mixture cost of 31.31 USD, to be added for a ton of biodiesel. This simplex‐centroid mixture experimental design shows an ability to be applied in the biodiesel, oils and fats industry to evaluate the oxidation stability and the occurrence of synergism between different mixtures of synthetic or natural antioxidants and their costs.
Psychometric Properties of the Chinese Version of the Kid-KINDLR Questionnaire for Measuring the Health-related Quality of Life of School-aged Children
Authors: Chan Phoebe L.C. , Ng Serena S.W. , Chan Dora Y.L. 
Published: August 2014

Objective/Background The reliability and validity of the Chinese version of the Kid-KINDLR questionnaire were examined with school-aged children in Hong Kong. Methods A total of 112 healthy children were selected by convenience sampling from two primary schools and 30 children with global developmental delay were selected from an outpatient occupational therapy department of a convalescent hospital. The Kid-KINDLR questionnaire was translated using independent forward and backward translation. The content validity of the translated instrument was evaluated by four experts. Internal consistency, factor analysis, and construct validity were examined in the healthy children group, whereas known-group comparison was performed in the group with global developmental delay. Results The significance value of the Shapiro—Wilk test was greater than 0.05, indicating that the sample displayed a normal distribution. The total score had good internal consistency (Cronbach's alpha = .77); however, the consistency of the subscales varied (Cronbach's alpha ranged from .47 to .70). The children and parent questionnaires did not load onto the six factors originally hypothesized. Instead, seven factors were generated. Evidence supporting the questionnaire's validity included a lack of age and sex bias and positive known-group differentiation (Wilks’ lambda = 0.906, p = .035). Conclusion The Chinese version of the Kid-KINDLR questionnaire exhibited good psychometric properties, but the internal consistency of the translated instrument needs further improvement. It is recommended that practitioners focus on the Kid-KINDLR total score when interpreting the Kid-KINDLR data. Overall, the study findings indicate that the Chinese version of the Kid-KINDLR is an important tool for use in clinical practice.
Status epilepticus as presenting manifestation of H1N1 infection
Authors: Takkar Aastha , Goyal Manoj , Modi Manish , Kharbanda Parampreet , Yaddanapudi Lakshminarayana , Lal Vivek , Prabhakar Sudesh 
Published: August 2014

Abstract
Background During the global H1N1 pandemic, neurological complications were reported in approximately 6–10% of children suffering from H1N1 infection, but only rarely in adults. Generalized convulsive status epilepticus (GCSE) as a presenting manifestation of H1N1 infection in an adult is exceedingly rare and has not been reported in literature. We report a patient who presented to us with GCSE as a presenting manifestation of H1N1 infection who improved following appropriate antiviral treatment.
Methods and results This 20-year-old gentleman presented to us with history of fever followed by GCSE of 24 h duration. He was treated symptomatically and was evaluated in detail. He was diagnosed to be suffering from H1N1 infection based on appropriate serological tests. After start of antiviral therapy, he improved and is doing well at 4 months follow up.
Conclusion This case report further expands the spectrum of clinical findings associated with sporadic H1N1 infection. A possibility of H1N1 infection should be considered in all patients who present with GCSE without any obvious cause so that appropriate diagnostic tests and treatment can be carried out at the earliest.
Trends in preterm birth in singleton deliveries in a Hong Kong population
Authors: Hui Annie S.Y. , Lao Terence T. , Leung Tak Yeung , Schaaf Jelle M. , Sahota Daljit S. 
Published: August 2014

AbstractObjectiveTo examine trends in preterm birth and its relationship with perinatal mortality in Hong Kong.MethodsIn a retrospective cohort study, data were reviewed from singletons delivered between 1995 and 2011 at a university teaching hospital. Trends in preterm birth (between 24 and 36 weeks of pregnancy), perinatal mortality, and subtypes of preterm birth (spontaneous, iatrogenic, and following preterm premature rupture of membranes [PPROM]) were examined via linear regression.ResultsThere were 103 364 singleton deliveries, of which 6722 (6.5%) occurred preterm, including 1835 (1.8%) early preterm births (24–33 weeks) and 4887 (4.7%) late preterm births (34–36 weeks). Frequency of preterm birth remained fairly consistent over the study period, but that of spontaneous preterm birth decreased by 25% (β = −0.83; P < 0.001), from 4.5% to 3.8%. Frequency of preterm birth following PPROM increased by 135% (β = 0.82; P < 0.001), from 0.7% to 1.7%. The perinatal mortality rate decreased from 56.7 to 37.0 deaths per 1000 deliveries before 37 weeks (β = −0.16; P = 0.54). Early preterm birth contributed to 16.0% of all deaths.ConclusionAlthough the overall rate of preterm birth in Hong Kong has remained constant, the frequencies of its subtypes have changed. Overall perinatal mortality is gradually decreasing, but early preterm birth remains a major contributor.
Serum metabolomic profiles evaluated after surgery may identify patients with oestrogen receptor negative early breast cancer at increased risk of disease recurrence. Results from a retrospective study
Authors: Tenori Leonardo , Oakman Catherine , Morris Patrick G. , Gralka Ewa , Turner Natalie , Cappadona Silvia , Fornier Monica , Hudis Cliff , Norton Larry , Luchinat Claudio , Di Leo Angelo 
Published: August 2014

PurposeMetabolomics is a global study of metabolites in biological samples. In this study we explored whether serum metabolomic spectra could distinguish between early and metastatic breast cancer patients and predict disease relapse.MethodsSerum samples were analysed from women with metastatic (n = 95) and predominantly oestrogen receptor (ER) negative early stage (n = 80) breast cancer using high resolution nuclear magnetic resonance spectroscopy. Multivariate statistics and a Random Forest classifier were used to create a prognostic model for disease relapse in early patients.ResultsIn the early breast cancer training set (n = 40), metabolomics correctly distinguished between early and metastatic disease in 83.7% of cases. A prognostic risk model predicted relapse with 90% sensitivity (95% CI 74.9–94.8%), 67% specificity (95% CI 63.0–73.4%) and 73% predictive accuracy (95% CI 70.6–74.8%). These results were reproduced in an independent early breast cancer set (n = 40), with 82% sensitivity, 72% specificity and 75% predictive accuracy. Disease relapse was associated with significantly lower levels of histidine (p = 0.0003) and higher levels of glucose (p = 0.01), and lipids (p = 0.0003), compared with patients with no relapse.ConclusionsThe performance of a serum metabolomic prognostic model for disease relapse in individuals with ER‐negative early stage breast cancer is promising. A confirmation study is ongoing to better define the potential of metabolomics as a host and tumour‐derived prognostic tool.
Global assessment of select phytonutrient intakes by level of fruit and vegetable consumption
Authors: Murphy Mary M. , Barraj Leila M. , Spungen Judith H. , Herman Dena R. , Randolph R. Keith 
Published: August 2014

Despite dietary recommendations that have repeatedly underscored the importance of increasing consumption of fruits and vegetables, intakes worldwide are lower than recommended levels. Consequently, the diets of many individuals may be lacking in nutrients and phytonutrients typical of a diet rich in a variety of fruits and vegetables. In the present study, we estimated phytonutrient intakes by adults categorised by sex, level of fruit and vegetable consumption ( < 5v.≥ 5 servings/d), and geographic diet cluster. Intakes of nine select phytonutrients were estimated from the 2002–4 World Health Survey fruit and vegetable servings intake data (n198 637), the FAO supply utilisation accounts data, and phytonutrient concentration data obtained from the US Department of Agriculture databases and the published literature. Percentage contributions to each phytonutrient intake from fruit and vegetable sources were also estimated. Estimated intakes of phytonutrients from fruits and vegetables varied across the thirteen geographic diet clusters, reflecting regional differences in both numbers and proportions of fruit and vegetable servings consumed, and the specific types of fruits and vegetables available in the diet. The mean phytonutrient intakes by adults consuming ≥ 5 servings/d of fruits and vegetables were approximately 2- to 6-fold the mean phytonutrient intakes by adults with low fruit and vegetable consumption ( < 5 servings/d). In some cases, phytonutrient intakes by adults consuming ≥ 5 servings/d of fruits and vegetables in one geographic diet cluster were lower than the intakes by adults reporting < 5 servings/d in another cluster. The findings from this assessment provide important information regarding the major dietary patterns of phytonutrient intakes across geographic diet clusters.
Phytonutrient intakes in relation to European fruit and vegetable consumption patterns observed in different food surveys
Authors: Tennant David R. , Davidson Julia , Day Andrea J. 
Published: August 2014

Fruit and vegetables make an important contribution to health, partly due to the composition of phytonutrients, such as carotenoids and polyphenols. The aim of the present study was to quantify the intake of fruit and vegetables across different European countries using food consumption data of increasing complexity: food balance sheets (FBS); the European Food Safety Authority (EFSA) Comprehensive Database; individual food consumption data from the UK National Diet and Nutrition Survey (NDNS). Across Europe, the average consumption of fruit and vegetables ranged from 192 to 824 g/d (FBS data). Based on EFSA data, nine out of fourteen countries consumed < 400 g/d (recommended by the WHO), although even in the highest-consuming countries such as Spain, 36 % did not reach the target intake. In the UK, the average consumption of fruit and vegetables was 310 g/d (NDNS data). Generally, phytonutrient intake increased in accordance with fruit and vegetable intake across all European countries with the exception of lycopene (from tomatoes), which appeared to be higher in some countries that consumed less fruit and vegetables. There were little differences in the average intake of flavanols, flavonols and lycopene in those who did or did not meet the 400 g/d recommendation in the UK. However, average intakes of carotenoid, flavanone, anthocyanidin and ellagic acid were higher in those who consumed >400 g/d of fruit and vegetables compared with those who did not. Overall, intakes of phytonutrients are highly variable, suggesting that while some individuals obtain healthful amounts, there may be others who do not gain all the potential benefits associated with phytonutrients in the diet.
The epidemiology and global burden of autism spectrum disorders
Authors: Baxter A. J. , Brugha T. S. , Erskine H. E. , Scheurer R. W. , Vos T. , Scott J. G. 
Published: August 2014

BackgroundAutism spectrum disorders (ASDs) are persistent disabling neurodevelopmental disorders clinically evident from early childhood. For the first time, the burden of ASDs has been estimated for the Global Burden of Disease Study 2010 (GBD 2010). The aims of this study were to develop global and regional prevalence models and estimate the global burden of disease of ASDs.MethodA systematic review was conducted for epidemiological data (prevalence, incidence, remission and mortality risk) of autistic disorder and other ASDs. Data were pooled using a Bayesian meta-regression approach while adjusting for between-study variance to derive prevalence models. Burden was calculated in terms of years lived with disability (YLDs) and disability-adjusted life-years (DALYs), which are reported here by world region for 1990 and 2010.ResultsIn 2010 there were an estimated 52 million cases of ASDs, equating to a prevalence of 7.6 per 1000 or one in 132 persons. After accounting for methodological variations, there was no clear evidence of a change in prevalence for autistic disorder or other ASDs between 1990 and 2010. Worldwide, there was little regional variation in the prevalence of ASDs. Globally, autistic disorders accounted for more than 58 DALYs per 100 000 population and other ASDs accounted for 53 DALYs per 100 000.ConclusionsASDs account for substantial health loss across the lifespan. Understanding the burden of ASDs is essential for effective policy making. An accurate epidemiological description of ASDs is needed to inform public health policy and to plan for education, housing and financial support services.
Simulation-based fast collision detection for scaled polyhedral objects in motion by exploiting analytical contact equations
Authors: Liu Jing-Sin , Pan Wen-Hua , Ku Wen-Yang , Tsao Y.-H. , Chang Y.-Z. 
Published: August 2014

SUMMARYBased on the results of the study of convex object motion1 (J. Hopcroft and G. Wilfong, “Motion of objects in contact,” Int. J. Robot. Res., 4(4), 32–46 (1986)), this paper addresses the problem of exact collision detection of a pair of scaled convex polyhedra in relative motion, and determines the contact conditions of tangential contact features, arbitrary relative motion involving translation and rotation, and uniform scaling of the objects about a fixed point. We propose a new concept of the decision curve based on analytical contact equations that characterize a continuum of scaling factors (or a single scaling factor), which ensures that a pair of objects undergoing a scaling transformation will maintain the same tangential contact feature pair (or make instantaneous tangential contact feature transitions). We propose a reliable simulation-based approach to construct the decision curve by hybridizing analytical contact equations and conventional collision detection method, called the Fast Collision Detection Method (FCDM). This method can determine whether two scaled objects will make contact at specific tangential contact features (vertices, edges, or faces) under particular uniform scaling factors and after distinctive relative motion with better accuracy and less computational time than the existing collision detection methods. Finally, we demonstrate our approach for solving motion design in simple assembly/disassembly problems.
The association between invasive Lantana camara and seedlings/saplings of a plant community in Mudumalai Tiger Reserve, India
Authors: Wilson Gaius , Desai Ajay A. , Sim Dalice A. , Gruber Monica A. M. , Lester Philip J. 
Published: August 2014

Abstract:We examined changes in a community of seedlings/saplings 10–150 cm tall associated with the presence of a widely invasive plant, Lantana camara and environmental covariates along 67 randomly located transects, in Mudumalai, India. We compared plant species assemblage and grass cover in L. camara-invaded and uninvaded plots in three habitats. Multivariate analyses revealed a significant association of all environmental covariates with plant species assemblage. Pairwise tests indicated that L. camara was significantly associated with changes in plant species assemblage and grass cover within the moist and dry deciduous forest, but not in the thorn forest. The relationship between L. camara and that of elephant browse plants varied with species. A linear regression analysis indicated that L. camara invasion was the only significant predictor of grass occupancy. Our results indicate that in addition to other factors, L. camara was associated with altering plant species assemblage, some elephant browse plants and grass cover in the moist and dry deciduous forest. It appears that L. camara can have a major effect on diversity within this reserve, but whether this effect is by L. camara driving the change or being associated with other habitat change requires further experimental evidence.
Stepping on Congress
Authors: Maltzman Forrest , Mark Alyx , Shipan Charles R. , Zilis Michael A. 
Published: August 2014

AbstractLegislative enactment is only one step in the life of a law. How a law shapes public life after enactment is frequently the result of whether the judiciary interprets the provisions contained in a law and how courts reconcile provisions within and across laws. But the factors that determine whether the judiciary ends up playing such a role are not well understood. We investigate why the courts, through statutory interpretation, address some major laws but not others and why some laws are addressed soon after enactment, while others are on the books for years before they reach the judicial branch. Our evidence shows that conditions at the time of enactment, plus features of the law, play a major role in determining whether, and when, a law reaches the courts. More specifically, both divided government and disagreement between the two chambers increase the likelihood that the courts will address significant laws.
Can Agricultural Cooperatives Reduce Poverty? Heterogeneous Impact of Cooperative Membership on Farmers' Welfare in Rwanda
Authors: Verhofstadt Ellen , Maertens Miet 
Published: August 2014

AbstractWe analyze the inclusiveness and effectiveness of agricultural cooperatives in Rwanda. We estimate mean income and poverty effects of cooperative membership using propensity score matching techniques. We analyze heterogeneous treatment effects across farmers by analyzing how estimated treatment effects vary over farm and farmer characteristics and over the estimated propensity score. We find that cooperative membership in general increases income and reduces poverty and that these effects are largest for larger farms and in more remote areas. We find evidence of a negative selection because impact is largest for farmers with the lowest propensity to be a cooperative member.
Modeling genome coverage in single-cell sequencing
Authors: Daley Timothy , Smith Andrew D. 
Published: August 2014

Abstract
Motivation: Single-cell DNA sequencing is necessary for examining genetic variation at the cellular level, which remains hidden in bulk sequencing experiments. But because they begin with such small amounts of starting material, the amount of information that is obtained from single-cell sequencing experiment is highly sensitive to the choice of protocol employed and variability in library preparation. In particular, the fraction of the genome represented in single-cell sequencing libraries exhibits extreme variability due to quantitative biases in amplification and loss of genetic material.
Results: We propose a method to predict the genome coverage of a deep sequencing experiment using information from an initial shallow sequencing experiment mapped to a reference genome. The observed coverage statistics are used in a non-parametric empirical Bayes Poisson model to estimate the gain in coverage from deeper sequencing. This approach allows researchers to know statistical features of deep sequencing experiments without actually sequencing deeply, providing a basis for optimizing and comparing single-cell sequencing protocols or screening libraries.
Availability and implementation: The method is available as part of the preseq software package. Source code is available at http://smithlabresearch.org/preseq .
Contact: andrewds@usc.edu
Supplementary information: Supplementary material is available at Bioinformatics online.
Fast construction of FM-index for long sequence reads
Authors: Li Heng 
Published: August 2014

Abstract
Summary: We present a new method to incrementally construct the FM-index for both short and long sequence reads, up to the size of a genome. It is the first algorithm that can build the index while implicitly sorting the sequences in the reverse (complement) lexicographical order without a separate sorting step. The implementation is among the fastest for indexing short reads and the only one that practically works for reads of averaged kilobases in length.
Availability and implementation: https://github.com/lh3/ropebwt2
Contact: hengli@broadinstitute.org
Using simulated escape events to assess the annual numbers and
destinies of escaped farmed Atlantic salmon of different life stages from farm
sites in Norway
Authors: Skilbrei Ove T. , Heino Mikko , Svåsand Terje 
Published: August 2014

Abstract
To improve assessments of the environmental risks of aquaculture, a series of simulated escapes of farmed Atlantic salmon (Salmo salar L.) from seawater netpens were performed. Individually tagged post-smolts and adult Atlantic salmon were released from various locations at different times of the year. Post-smolts that escaped during their first summer were capable of rapid migration towards the open sea. A small fraction returned to spawn and were recaptured after 1–3 years at sea (0.4%, range 0.0–1.1%). A total of 13% of the post-smolts that escaped during autumn were reported in nearby fisheries during subsequent months, partly because they had grown large enough to be caught in the gillnets used, but more importantly because migratory behaviour diminished towards the end of the year. The mean recapture rate of adult salmon was high after releases in fjords (7–33%), lower after coastal releases (4–7%), and zero on the outer coast. Most of these recaptures were immature fish recaptured in sea relatively close to the release site during their first months post-release. Recaptures of adult escapees after 1–2 years in the wild were very rare (0.09%), probably because of their low survival. A Monte-Carlo method was developed to estimate the annual numbers of escapees from Norwegian fish farms based on reported catches of escaped farmed salmon in the sea and in rivers and the recapture probabilities reported here. The model provides a tool to estimate numbers of escapees independently from the reported numbers. Importantly, our analysis suggests that the total numbers of post-smolt and adult escapees have been two- to fourfold as high as the numbers reported to the authorities by fish farmers, depending on whether the incomplete sea fishery statistics are compensated for.