bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dengue: descrevendo a epidemia em Aracaju, Sergipe, Brasil, 2008
Authors: Cunha Paulo Emidio Lobão , Bohland Anna Klara 
Published: January 2013

Introdução: a dengue é um dos maiores problemas de saúde pública no Brasil, caracterizando-se como doença febril aguda, com espectro clínico variando desde quadros febris inespecíficos até manifestações graves com hemorragia e choque. A Vigilância Epidemiológica (VE) da dengue deve ter agilidade suficiente para detectar precocemente as epidemias, e juntamente com a organização da rede de assistência, minimizar os casos de evolução grave, reduzindo a letalidade. Objetivos: estudar o perfil epidemiológico da dengue na cidade de Aracaju no ano de 2008. Métodos: foi realizado um estudo transversal, sendo utilizadas as seguintes variáveis: sexo, idade do paciente, cor da pele, semana epidemiológica de notificação, região de saúde, classificação da forma clínica da doença, resultado do exame (Mac-Elisa) e óbito. As informações foram colhidas do banco de dados do Sistema de Informações de Agravos de Notificação da Secretaria de Estado da Saúde de Sergipe. Os dados foram formatados utilizando o programa Microsoft Office ExcelÒ e transferidos para o Stats Direct (versão 2.7.9), onde foi realizada a análise. Resultados: foram notificados 11348 casos e 10165 casos confirmados de dengue, com taxa de incidência de 1,89 casos/1000 habitantes em 2008. A maior incidência (por mil habitantes) foi sexo feminino (20,5), entre os 5 e 15 anos (26,1) e cor de pele parda (28,1). No que se refere à semana epidemiológica, o período compreendido entre a 9a e a 24a semanas apresentou o maior número de casos. A região de saúde com maior coeficiente foi a quarta (22,3). Quanto à realização do exame, 43,1% dos casos graves foram confirmados sem a sua realização. Dos casos confirmados, 96,1% foram classificados como dengue clássica, 2,6% como dengue com complicações, 1,2% como febre hemorrágica da dengue e apenas 2 casos (0,02%) como síndrome do choque da dengue. O diagnóstico final de dengue comparado à sorologia apresentou uma sensibilidade de 99,4% e uma especificidade de 97,0%. A taxa de letalidade nos casos graves foi de 4,6%. Conclusão: o melhor entendimento epidemiológico da doença permitirá o aprimoramento da vigilância, detectando mais precocemente e evitando novas epidemias da doença.
Well-Differentiated Endocrine Carcinoma Originating From the Bile Duct in Association With a Congenital Choledochal Cyst
Authors: Takahashi Kazuhiro , Sasaki Ryoko , Oshiro Yukio , Fukunaga Kiyoshi , Oda Tatsuya , Ohkohchi Nobuhiro 
Published: January 2013

AbstractWe encountered a rare case of a well-differentiated endocrine carcinoma originating from the bile duct in association with a congenital choledochal cyst (CCC). The patient is a 28-year-old woman referred to our clinic for pruritus. Laboratory data showed mild elevation of serum hepatobiliary enzymes. Computed tomography and magnetic resonance imaging demonstrated pancreatobiliary maljunction and a Todani type IV-A CCC from the inferior bile duct to the bilateral intrahepatic bile ducts. A solid tumor was detected in the middle portion of the common bile duct. Pancreatoduodenectomy and total extrahepatic bile duct resection was performed. Based on pathologic and immunohistochemical examinations, a diagnosis of well-differentiated endocrine carcinoma was made according to the World Health Organization criteria. To our knowledge, this is the third report of a neuroendocrine tumor originating from the bile duct in association with a CCC.
A Literature Review on the Role of Totally Extraperitoneal Repairs for Groin Pain in Athletes
Authors: Siddiqui Muhammad R. S. , Kovzel Makysym , Brennan Stephen , Priest Oliver H. , Preston Shaun R. , Soon Yuen 
Published: January 2013

Abstract
A literature review was made on the role of totally extraperitoneal (TEP) hernia repairs for groin pain in athletes. Electronic databases were searched for literature published from January 1993 to November 2011. There were 10 articles incorporating 196 patients included in this review. Thirty percent of patients were reported to have direct inguinal hernias, 22% had indirect inguinal hernias, and 41% had dilated internal rings. Of note, 30% of cases had no macroscopic abnormality. Four studies reported on an early follow-up ranging between 3 and 6 weeks. Only minimal or mild symptoms were reported. Up to 33% of patients had impaired ability to perform at peak levels. Up to 53% of patients had persistence of symptoms at the early follow-up. Total follow-up time ranged from 3 to 80 months, and most patients were active (90%–100%). At long-term follow-up, 3% to 10% were unable to play, and 5% were reported as being unable to train. Two studies from the same center reported on TEP surgery for osteitis pubis, and most patients returned to sporting activity after 4 to 8 weeks. TEP repair is a good operative intervention in athletes with chronic groin pain not relieved by conservative measures. Athletes recover quickly and return to sport early.
Usefulness of Indocyanine Green Angiography for Evaluation of Blood Supply in a Reconstructed Gastric Tube During Esophagectomy
Authors: Ishiguro Toru , Kumagai Youichi , Ono Tomojiro , Imaizumi Hideko , Honjo Hiroaki , Suzuki Okihide , Ito Tetsuya , Haga Norihiro , Kuwabara Kohki , Sobajima Jun , Kumamoto Kensuke , Ishibashi Keiichoro , Baba Hiroyuki , Ishida Hideyuki , Kawano Tatsuyuki 
Published: January 2013

Abstract
We report a case of necrosis of a reconstructed gastric tube in a 77-year-old male patient who had undergone esophagectomy. At the time of admission, the patient had active gastric ulcers, but these were resolved by treatment with a proton pump inhibitor. Subtotal esophagectomy with gastric tube reconstruction was performed. Visually, the reconstructed gastric tube appeared to be well perfused with blood. Using indocyanine green (ICG) fluorescence imaging the gastroepiploic vessels were well enhanced and no enhancement was visable 3 to 4 cm from the tip of the gastric tube. Four days after esophagectomy, gastric tube necrosis was confirmed, necessitating a second operation. The necrosis of the gastric tube matched the area that had been shown to lack blood perfusion by ICG angiography imaging. It seems that ICG angiography is useful for the evaluation of perfusion in a reconstructed gastric tube.
Neutrophil-to-Lymphocyte Ratio Has a Close Association With Gangrenous Appendicitis in Patients Undergoing Appendectomy
Authors: Ishizuka Mitsuru , Shimizu Takayuki , Kubota Keiichi 
Published: January 2013

Abstract
The purpose of this study was to clarify the clinical features most closely associated with gangrenous appendicitis. From among 314 patients who had undergone open appendectomy in our collected database, 222 for whom sufficient data were evaluable were enrolled. The results of univariate analysis revealed that age (≤40/&gt;40 years), sex (female/male), fever (≤37°/&gt;37°C), the serum levels of C-reactive protein and albumin, the Glasgow prognostic score (0, 1/2), and the neutrophil-to-lymphocyte ratio (NLR) (≤8/&gt;8) were associated with gangrenous appendicitis. Among these 7 clinical features, multivariate analysis disclosed that age (≤40/&gt;40 years) (odds ratio, 3.435; 95% confidence interval 1.744–6.766; P &lt; 0.001) and NLR (≤8/&gt;8) (odds ratio, 3.016; 95% confidence interval 1.535–5.926; P  =  0.001) were associated with gangrenous appendicitis. The sensitivity and specificity of these two clinical features were 65% and 27%, and 73% and 39%, respectively. NLR (&gt;8) shows a significant association with gangrenous appendicitis in patients undergoing appendectomy.
Distally Based Dorsal Digital Fasciocutaneous Flap for the Repair of Digital Terminal Amputation Defects
Authors: Hou Ruixing , Ju Jihui , Zhao Qiang , Liu Yuefei 
Published: January 2013

Abstract
The preferred plastic surgery regimen for distal digital segment wounds remains unknown, although multiple options are available for the repair. The purpose of this investigation is to study its anatomic rationale and clinical outcomes, in addition to the role of dorsal digital veins in digital reconstruction. Patients (n  =  765) suffering from digital terminal segment traumatic wounds (823 digits) were identified and reviewed in a retrospective manner. The wounds were repaired using distally based dorsal digital fasciocutaneous flaps with venoneuroadipofascial pedicles. Skin flaps survived in 818 digits (99.4%), whereas 5 flaps (0.6%) became partially necrotic. Postoperative follow-up data were available from 521 patients involving 559 digits, for an average duration of 10 months (range, 4–36 months). The wider pedicled fascial flap (1.0–1.5 cm) was significantly associated with a decreased occurrence of blebs, whereas the first few patients with pedicled fascial flaps 0.5 to 1.0 cm wide exhibited more frequent occurrence of blebs and flap contractures. The flaps retracted in size within the first 2 to 3 months at the rate of 10% compared with the intraoperative outlined size. The skin flaps became mildly pigmented within the first postoperative month, and at 6 months the flaps turned brighter in color, almost approximating the color of the normal digits. At 12 months, both the texture and appearance of the flaps were acceptable. The donor sites healed without any scar contracture. The digital terminals appeared grossly normal with acceptable digital function. Without any neural reconstruction, skin flap sensation was rated as S2 to S3+, whereas with neural reconstruction the 2-point discrimination sensitivity measured 4 to 9 mm. The use of a distally based dorsal digital fasciocutaneous flap with venoneuroadipofascial pedicle was a simple, safe, and less invasive regimen for repairing digital terminal segment wounds.
Pure de novo partial trisomy 6p in a girl with craniosynostosis
Authors: Varvagiannis Konstantinos , Stefanidou Amalia , Gyftodimou Yolanda , Lord Helen , Williams Louise , Sarri Catherine , Pandelia Efi , Bazopoulou‐Kyrkanidou Euterpe , Noakes Charlotte , Lester Tracy , Wilkie Andrew O.M. , Petersen Michael B. 
Published: January 2013

AbstractDuplications of chromosome 6p are rarely reported. We present the case of a girl with a de novo trisomy 6p12.3–p21.1 who showed clinical features characteristic of this syndrome, notably facial anomalies, psychomotor delay, and recurrent respiratory tract infections. The most striking feature, however, was craniosynostosis, manifested by the premature fusion of the right coronal and sagittal sutures. A review of the literature revealed that the presence of abnormal fontanelles and sutures is relatively common among patients with proximal trisomy 6p. Exclusion of the most frequently occurring craniosynostosis mutations, as well as of further chromosomal anomalies in our case, suggest the presence of a gene regulating suture formation within this region. Based on recent findings, we hypothesize that the runt‐related transcription factor 2 (RUNX2) may be a reasonable candidate gene for craniosynostosis in such patients. © 2013 Wiley Periodicals, Inc.
Photodynamic therapy of antibiotic‐resistant biofilms in a maxillary sinus model
Authors: Biel Merrill A. , Pedigo Lisa , Gibbs Aaron , Loebel Nicolas 
Published: January 2013

BackgroundChronic rhinosinusitis (CRS) is one of the most common chronic conditions in the United States. There is a significant subpopulation of CRS patients who remain resistant to cure despite rigorous treatment regimens including surgery, allergy therapy, and prolonged antibiotic therapy. Antimicrobial photodynamic therapy (aPDT) is a noninvasive nonantibiotic broad spectrum antimicrobial treatment. Our previous in vitro studies demonstrated that aPDT reduced CRS polymicrobial planktonic bacteria and fungi by >99.9% after a single treatment. However, prior to human treatment, the effectiveness of aPDT to eradicate polymicrobial biofilms in a maxillary sinus cavity must be demonstrated. The objective of this study was to demonstrate the effectiveness of a noninvasive aPDT treatment of antibiotic resistant biofilms known to cause CRS in a novel anatomically correct maxillary sinus in vitro model using an enhanced photosensitizer solution.MethodsAntibiotic resistant polymicrobial biofilms of Pseudomonas aeruginosa and methicillin‐resistant Staphylococcus aureus (MRSA) were grown in an anatomically correct novel maxillary sinus model and treated with a methylene blue/ethylenediamine tetraacetic acid (EDTA) photosensitizer and 670‐nm nonthermal activating light. Cultures of the biofilms were obtained before and after light treatment to determine efficacy of biofilm reduction.ResultsThe in vitro maxillary sinus CRS biofilm study demonstrated that aPDT reduced the CRS polymicrobial biofilm by >99.99% after a single treatment.ConclusionaPDT can effectively treat CRS polymicrobial antibiotic resistant Pseudomonas aeruginosa and MRSA biofilms in a maxillary sinus cavity model.
Cost‐effectiveness of endoscopic sphenopalatine artery ligation versus nasal packing as first‐line treatment for posterior epistaxis
Authors: Dedhia Raj C. , Desai Shamit S. , Smith Kenneth J. , Lee Stella , Schaitkin Barry M. , Snyderman Carl H. , Wang Eric W. 
Published: January 2013

BackgroundThe advent of endoscopic sphenopalatine artery ligation (ESPAL) for the control of posterior epistaxis provides an effective, low‐morbidity treatment option. In the current practice algorithm, ESPAL is pursued after failure of posterior packing. Given the morbidity and limited effectiveness of posterior packing, we sought to determine the cost‐effectiveness of first‐line ESPAL compared to the current practice model.MethodsA standard decision analysis model was constructed comparing first‐line ESPAL and current practice algorithms. A literature search was performed to determine event probabilities and published Medicare data largely provided cost parameters. The primary outcomes were cost of treatment and resolution of epistaxis. One‐way sensitivity analysis was performed for key parameters.ResultsCosts for the first‐line ESPAL arm and the current practice arm were $6450 and $8246, respectively. One‐way sensitivity analyses were performed for key variables including duration of packing. The baseline difference of $1796 in favor of the first‐line ESPAL arm was increased to $6263 when the duration of nasal packing was increased from 3 to 5 days. Current practice was favored (cost savings of $437 per patient) if posterior packing duration was decreased from 3 to 2 days.ConclusionThis study demonstrates that ESPAL is cost‐saving as first‐line therapy for posterior epistaxis. Given the improved effectiveness and patient comfort of ESPAL compared to posterior packing, ESPAL should be offered as an initial treatment option for medically stable patients with posterior epistaxis.
Sinonasal manifestations of sarcoidosis: a single institution experience with 38 cases
Authors: Aloulah Mohammad , Manes R. Peter , Ng Yuk Hui , Fitzgerald John E. , Glazer Craig S. , Ryan Matthew W. , Marple Bradley F. , Batra Pete S. 
Published: January 2013

BackgroundSarcoidosis is a chronic disease process characterized by non‐caseating granulomatous inflammation, usually involving the lower respiratory tract. Given the rarity of rhinologic involvement, the objectives of the present study were (1) to describe clinical features, and (2) to review outcomes of rhinologic surgery for sinonasal sarcoidosis.MethodsRetrospective analysis was performed of patients evaluated at a tertiary care referral center between January 2006 and July 2011.ResultsThe mean age of the 38 patients with sinonasal sarcoidosis was 52 years, with a female:male ratio of 2.8:1. The most common presenting symptoms included nasal obstruction (65.8%), crusting (29.9%), and epistaxis (18.4%). Most frequent endoscopic findings included crusting (55.3%), mucosal thickening (44.7%), and subcutaneous nodules (21%). Computed tomography (CT) imaging demonstrated turbinate or septal nodularity (21%), osteoneogenesis (15.8%), and bone erosion (10.5%). Medical management was typically comprised of saline irrigations (73.3%), topical nasal steroids (68.4%), and oral steroids (63.2%). Refractory sinus symptoms required sinonasal surgery in 4 cases. Overall subjective symptom improvement was noted in 39.5% at mean follow‐up of 16.2 months.ConclusionSinonasal involvement was noted in approximately 30% of patients with known sarcoidosis evaluated in the otolaryngology clinic. Patients typically present with nasal obstruction and endoscopic evidence of crusting and mucosal thickening. Medical therapy with irrigations and topical/oral steroids suffices in majority of patients, with surgery for refractory symptoms being required in a small subset of cases.
Nanostructured Electrodes for High‐Performance Pseudocapacitors
Authors: Lu Qi , Chen Jingguang G. , Xiao John Q 
Published: January 2013

AbstractThe depletion of traditional energy resources as well as the desire to reduce high CO2 emissions associated with energy production means that energy storage is now becoming more important than ever. New functional electrode materials are urgently needed for next‐generation energy storage systems, such as supercapacitors or batteries, to meet the ever increasing demand for higher energy and power densities. Advances in nanotechnology are essential to meet those future challenges. It is critical to develop ways of synthesizing new nanomaterials with enhanced properties or combinations of properties to meet future challenges. In this Minireview we discuss several important recent studies in developing nanostructured pseudocapacitor electrodes, and summarize three major parameters that are the most important in determining the performance of electrode materials. A technique to optimize these parameters simultaneously and to achieve both high energy and power densities is also introduced.
Attrition of granola as a function of manufacturing process parameters during fluidised bed granulation and subsequent pneumatic conveying
Authors: Pathare Pankaj B. , Baş Nurşin , Byrne Edmond P. 
Published: January 2013

ABSTRACTThe present study examines the breakage of particulate granola produced by fluidised bed granulation during pneumatic conveying process. Granola was pneumatically conveyed in a purpose built conveying rig designed to mimic product conveying and packaging. Three different conveying rig configurations were employed: a straight pipe, a rig consisting two 45o bends and one with a 90o bend. Particle breakage increases with applied pressure drop, and a 90o bend pipe results in more attrition for all conveying velocities relative to other pipe geometry. In terms of the fluidised bed granulation, there was no single operating parameter that was deemed to have a significant effect on breakage during subsequent conveying. A simple power law breakage model based on process input parameters was developed to describe aggregate breakage during pneumatic conveying. © 2013 Curtin University of Technology and John Wiley & Sons, Ltd.
Analytical problems with the determination of coenzyme Q10 in biological samples
Authors: Turkowicz Monika Joanna , Karpińska Joanna 
Published: January 2013

AbstractThe article discusses analytical problems related to the determination of coenzyme Q10 in biological samples. The assaying of coenzyme Q10 in complex samples, such as plasma, tissues, or food items requires meticulous sample preparation prior to final quantification. The process typically consists of the following steps: deproteinization, extraction, and ultimately reduction of extract volumes. At times drying under a gentle stream of neutral gas is applied. In the case of solid samples, a careful homogenization is also required. Each step of the sample preparation process can be a source of analytical errors that may lead to inaccurate results. The main aim of this work is to point to sources of analytical errors in the preparation process and their relation to physicochemical properties of coenzyme Q10. The article also discusses ways of avoiding and reducing the errors. © 2012 BioFactors, 2013
A Triazatruxene‐Based Glycocluster as a Fluorescent Sensor for Concanavalin A
Authors: Wang Ke‐Rang , Wang Yue‐Qing , An Hong‐Wei , Zhang Jin‐Chao , Li Xiao‐Liu 
Published: January 2013

AbstractA new triazatruxene‐based fluorescent glycocluster has been designed, synthesized, and fully characterized by NMR spectroscopy and mass spectrometry. Furthermore, its specific and selective binding properties with concanavalin A (Con A) have been investigated by fluorescence spectroscopy, circular dichroism (CD) spectroscopy, and turbidity assay. The obtained results showed that the multivalent mannose‐modified triazatruxene exhibited specific binding with Con A, but no binding to peanut agglutinin (PNA) lectin or bovine serum albumin (BSA), corresponding to a two‐orders‐of‐magnitude higher affinity than that of monovalent mannose ligands. Most interestingly, a fluorescence enhancement of the triazatruxene‐based glycocluster was observed upon binding with Con A because of hydrophobic interactions involving sites close to the triazatruxene moiety. Furthermore, the inhibitory ability of the triazatruxene‐based glycocluster against ORN178‐ induced haemagglutination has been investigated by haemagglutination inhibition assay. The results indicated selective binding with ORN178.
Role‐Allocated Combination of Two Types of Hydrogen Bonds towards Constructing a Breathing Diamondoid Porous Organic Salt
Authors: Yamamoto Atsushi , Hasegawa Tetsuya , Hamada Tomoya , Hirukawa Tomofumi , Hisaki Ichiro , Miyata Mikiji , Tohnai Norimitsu 
Published: January 2013

AbstractA diamondoid porous organic salt (d‐POS) composed of 8‐hydroxyquinoline‐5‐sulfonic acid (HQS) and triphenylmethylamine (TPMA) shows reversible structure contraction and expansion (“breathing”) in response to guest desorption and adsorption. This flexible structure is designed hierarchically by utilizing two different types of hydrogen bonds. X‐ray crystallographic analysis reveals that the two types of hydrogen bonds are formed separately to play respective roles for constructing the d‐POS. The strong charge‐assisted hydrogen bond between the sulfonate anion of HQS and the ammonium cation of TPMA serves as a static node to provide a supramolecular cluster for a building block. In contrast, the complementary neutral hydrogen bond between the hydroxyl and quinolyl groups of HQS acts as a dynamic linker to connect the clusters. Consequently, these two types of hydrogen bonds yield the d‐POS with one‐dimensional channels through the formation of diamondoid networks. We clarify that the d‐POS undergoes dynamic structure transformation that originates in the cleavage and reformation of the complementary neutral hydrogen bond during guest desorption and adsorption. From the comparative studies, it is also demonstrated that applying the complementary neutral hydrogen bond in the d‐POS provides significant advantages in terms of the responsivity of the structure over applying other weak noncovalent interactions for the connection of the clusters. Furthermore, the resultant d‐POS also modulates fluorescent profiles dynamically responsive to guest adsorption and desorption.