bluuebunny/crossref_metadata_2025_split huggingface dataset:
La Garantie de Qualité des Données Géospatiales
Authors: Plante Katherine , Gervais Marc 
Published: June 2015

Les données géospatiales sont maintenant omniprésentes au sein de notre société et sont abondamment utilisées autant par les institutions publiques pour remplir leur mission que par les citoyens dans la gestion courante de leurs affaires. La diffusion des données géospatiales soulève des interrogations quant à la nature du contrat applicable et de la garantie de qualité qui peut y être applicable. Les données doivent-elles être appréhendées telles des biens corporels ou incorporels? Les garanties usuelles définies au sein de notre législation trouvent-elles application si ce sont des biens incorporels? Qu'en est-il des caractéristiques particulières des données géospatiales? Est-ce simple d'en garantir la qualité? Cet article vise à présenter un tour d'horizon en matière de garantie de qualité des données géospatiales en droit québécois. Nous abordons d'abord les caractéristiques intrinsèques des données géospatiales, la notion de garantie de qualité et le concept d'exactitude ainsi que les garanties implicites et conventionnelles. Ensuite, nous investiguerons les effets que peuvent avoir les différentes catégories de contrat sur la portée, voire l'existence de la garantie de qualité. Le résultat de l'analyse est à l'effet que plusieurs déclinaisons possibles de la garantie de qualité existent, qu'il perdure encore certaines incertitudes juridiques faisant en sorte de compliquer la tâche d'une organisation désirant mettre en circulation des données géospatiales.
Concise Review: Manufacturing of Pancreatic Endoderm Cells for Clinical Trials in Type 1 Diabetes
Authors: Schulz Thomas C. 
Published: June 2015

Abstract

The cellular component of ViaCyte's VC-01 combination product for type 1 diabetes, pancreatic endoderm cells (PEC-01) derived from CyT49 human embryonic stem cells, matures after transplantation and functions to regulate blood glucose in rodent models. The aims in manufacturing PEC-01 at scale are to generate a consistent and robust transplantable population that functions reliably and safely in vivo. ViaCyte has integrated multiple bioprocessing strategies to enable a tightly controlled PEC-01 manufacturing process for clinical entry.

Significance
This review summarizes the manufacturing process for the first human embryonic stem cell-based candidate treatment for type 1 diabetes to enter clinical testing. It presents the key strategic principles used to enable scaled production of pancreatic endoderm and will have widespread interest in academia and biopharma.
Catalytically Active and Spectator Ce3+ in Ceria‐Supported Metal Catalysts
Authors: Kopelent René , van Bokhoven Jeroen A. , Szlachetko Jakub , Edebeli Jacinta , Paun Cristina , Nachtegaal Maarten , Safonova Olga V. 
Published: June 2015

AbstractIdentification of active species and the rate‐determining reaction steps are crucial for optimizing the performance of oxygen‐storage materials, which play an important role in catalysts lowering automotive emissions, as electrode materials for fuel cells, and as antioxidants in biomedicine. We demonstrated that active Ce3+ species in a ceria‐supported platinum catalyst during CO oxidation are short‐lived and therefore cannot be observed under steady‐state conditions. Using time‐resolved resonant X‐ray emission spectroscopy, we quantitatively correlated the initial rate of Ce3+ formation under transient conditions to the overall rate of CO oxidation under steady‐state conditions and showed that ceria reduction is a kinetically relevant step in CO oxidation, whereas a fraction of Ce3+ was present as spectators. This approach can be applied to various catalytic processes involving oxygen‐storage materials and reducible oxides to distinguish between redox and nonredox catalytic mechanisms.
Versatile In Situ Generated N‐Boc‐Imines: Application to Phase‐Transfer‐Catalyzed Asymmetric Mannich‐Type Reactions
Authors: Kano Taichi , Kobayashi Ryohei , Maruoka Keiji 
Published: June 2015

AbstractThe efficient construction of nitrogen‐containing organic compounds is a major challenge in chemical synthesis. Imines are one of the most important classes of electrophiles for this transformation. However, both the available imines and applicable nucleophiles for them are quite limited given the existing preparative methods. Described herein are imine precursors which generate reactive imines with a wide variety of substituents under mild basic conditions. This approach enables the construction of various nitrogen‐containing molecules which cannot be accessed by the traditional approach. The utility of the novel imine precursor was demonstrated in the asymmetric Mannich‐type reaction under phase‐transfer conditions.
Companions around the nearest luminous galaxies: Segregation and selection effects
Authors: Karachentsev I. D. , Kudrya Y. N. 
Published: June 2015

AbstractUsing the “Updated Nearby Galaxy Catalog”, we consider different properties of companion galaxies around luminous hosts in the Local Volume. The data on stellar masses, linear diameters, surface brightnesses, HI‐richness, specific star formation rate (sSFR), and morphological types are discussed for members of the nearest groups, including the Milky Way and M 31 groups, as a function of their separation from the hosts. Companion galaxies in groups tend to have lower stellar masses, smaller linear diameters, and fainter mean surface brightnesses as the distance to their host decreases. The hydrogen‐to‐stellar mass ratio of the companions increases with their linear projected separation from the dominant luminous galaxy. This tendency is more expressed around the bulge‐dominated hosts. While linear separation of the companions decreases, their mean sSFR becomes lower, accompanied with the increasing sSFR scatter. the typical linear projected separation of dSphs around the bulge‐dominated hosts, 350 kpc, is substantially larger than that around the disk‐dominated ones, 130 kpc. This difference probably indicates the presence of larger hot/warm gas haloes around the early‐type host galaxies. The mean fraction of dSph (quenched) companions in the 11 nearest groups as a function of their projected separation Rp can be expressed as ƒ(E) = (0.55–0.69)×Rp. The fraction of dSphs around the Milky Way and M 31 looks much higher than in other nearby groups because the quenching efficiency dramatically increases towards the ultra‐low mass companions. We emphasize that the observed properties of the Local Group are not typical for other groups in the Local Volume due to the role of selection effects caused by our location inside the Local Group. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Studies on metabolism of total glucosides of paeony from Paeoniae Radix Alba in rats by UPLC‐Q‐TOF‐MS/MS
Authors: Cao Wenli , Wang Xinguo , Li Haojie , Shi Xuliang , Fan Wencheng , Zhao Shaohua , Liu Minyan , Niu Liying 
Published: June 2015

AbstractTotal glucosides of paeony are the active constituents of Paeoniae Radix Alba. In this study, a novel strategy was proposed to find more metabolites and the differences between paeoniflorin, albiflorin and total glucosides of paeony (TGP). This strategy was characterized as follows: firstly, the animals were divided into three groups (paeoniflorin, albiflorin and TGP) to identify the source of TGP metabolites from paeoniflorin or albiflorin; secondly, a generic information‐dependent acquisition scan for the low‐level metabolites was triggered by the multiple mass defect filter and dynamic background subtraction; thirdly, the metabolites were identified with a combination of data‐processing methods including mass defect filtering, neutral loss filtering and product ion filtering; finally, a comparative study was used in the metabolism of paeoniflorin, albiflorin and TGP. Based on the strategy, 18 metabolites of TGP, 10 metabolites of paeoniflorin and 13 metabolites of albiflorin were identified respectively. The results indicated that the hydrolysis, conjugation reaction and oxidization were the major metabolic pathways, and the metabolic sites were the glycosidic linkage, the ester bond and the benzene ring. This study is first to explore the metabolism of TGP, and these findings enhance our understanding of the metabolism and the interactions of paeoniflrin and albiflorin in TGP. Copyright © 2015 John Wiley & Sons, Ltd.
Brand image and brand loyalty: Do they show the same deviations from a common underlying pattern?
Authors: Stocchi Lara , Driesener Carl , Nenycz‐Thiel Magda 
Published: June 2015

AbstractThe aim of the paper is to investigate whether deviations from the double jeopardy pattern observed in brand buying (panel) data such as niche brands (brands with few users, but high levels of brand loyalty) and change‐of‐pace brands (brands with many users, but low levels of brand loyalty) correspond with deviations from the same pattern in brand image data (i.e. brand image associations gathered through consumer surveys). The analysis of a unique data set in three product categories including brand purchases and brand image associations from the same consumers and for the same brands shows that such deviations in brand buying data and in brand image data seldom correspond. Moreover, deviations from the double jeopardy pattern in brand image data are rare and imply the existence of an underlying impact of a brand's associative rate (i.e. the average number of associations a brand obtains in a brand image consumer survey) on brand loyalty (measured as the frequency of brand buying). These findings provide contribution to buyer behaviour theory and have practical implications for branding strategies. For instance, to obtain any impact on brand loyalty, marketers may need to develop branding strategies aimed at increasing a brand's associative rate, whilst maintaining or enlarging its level of market penetration. Copyright © 2015 John Wiley & Sons, Ltd.
Effect of Bed Depth on Granular Flow and Homogenization in a Vertical Bladed Mixer via Discrete Element Method
Authors: Barczi Tomas , Travnickova Tereza , Havlica Jaromir , Kohout Martin 
Published: June 2015

AbstractThe mixing of powders and granular materials is decisive for the quality of a final product. Simulations of granular mixing via discrete element method are performed. Mixing was done in a vertical cylindrical mixer with two opposed flat blades with 90° rake angle. The effects of packed‐bed depth and blade rotational speed on the process of homogenization and on the development of flow patterns were evaluated. The process of homogenization was analyzed at macroscopic scale by global mixing indexes and at microscopic scale by the complex flow patterns with different nature. Macroscopic and microscopic approaches were connected and from flow pattern observation optimal conditions for the best homogenization were predicted.
Effects of Ranolazine in Patients With Chronic Angina in Patients With and Without Percutaneous Coronary Intervention for Acute Coronary Syndrome: Observations From the MERLIN‐TIMI 36 Trial
Authors: Gutierrez Jorge A. , Karwatowska‐Prokopczuk Ewa , Murphy Sabina A. , Belardinelli Luiz , Farzaneh‐Far Ramin , Walker Gennyne , Morrow David A. , Scirica Benjamin M. 
Published: June 2015

ABSTRACTBackgroundRanolazine, a piperazine derivative with anti‐ischemic effects, reduces the frequency of angina and improves exercise performance in patients with chronic angina. The effects of ranolazine in patients with established ischemic heart disease and chronic angina undergoing percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS) is not well described. We hypothesized that ranolazine would reduce ischemic events, regardless of revascularization.MethodsWe examined the 1‐year incidence of recurrent cardiovascular (CV) events in the subgroup of patients with prior chronic angina (n = 3565) enrolled in the randomized, double‐blind, placebo‐controlled Metabolic Efficiency with Ranolazine for Less Ischemia in Non‐ST‐Elevation ACS (MERLIN)–Thrombolysis In Myocardial Infarction (TIMI) 36 trial who did or did not have a PCI within 30 days of the index event.ResultsRanolazine reduced the risk of recurrent ischemia following admission regardless of whether patients had (hazard ratio [HR], 0.69; 95% confidence interval [CI] 0.51‐0.92] or did not have PCI (HR, 0.81; 95% CI, 0.66‐0.99; P interaction = 0.39). CV death, myocardial infarction, and recurrent ischemia were similarly lower with ranolazine in the PCI group (HR, 0.71; 95% CI, 0.55‐0.91) vs the non‐PCI group (HR, 0.91; 95% CI, 0.78‐1.06; P interaction = 0.10), with a nominally significant decrease in CV death (HR, 0.39; 95% CI, 0.16‐0.93) in the PCI group vs no difference in the non‐PCI group (HR, 1.19; 95% CI, 0.89‐1.59; P interaction = 0.02).ConclusionsIn patients with chronic angina, ranolazine reduced recurrent ischemic events, regardless of whether patients did or did not receive PCI within 30 days of a non‐ST‐segment ACS.
Disparities in survival by insurance status in patients with Hodgkin lymphoma
Authors: Parikh Rahul R. , Grossbard Michael L. , Green B. Lee , Harrison Louis B. , Yahalom Joachim 
Published: June 2015

BACKGROUNDThe association between insurance status and outcomes has not been well established for patients with Hodgkin lymphoma (HL). The purpose of this study was to examine the disparities in overall survival (OS) by insurance status in a large cohort of patients with HL.METHODSThe National Cancer Data Base (NCDB) was used to evaluate patients with stage I to IV HL from 1998 to 2011. The association between insurance status, covariables, and outcomes was assessed in a multivariate Cox proportional hazards model. Survival was estimated with the Kaplan‐Meier method.RESULTSAmong the 76,681 patients within the NCDB, 45,777 patients with stage I to IV HL were eligible for this study (median follow‐up, 6.0 years). The median age was 39 years (range, 18‐90 years). The insurance status was as follows: 3247 (7.1%) were uninsured, 7962 (17.4%) had Medicaid, 30,334 (66.3%) had private insurance, 3746 (8.2%) had managed care, and 488 (1.1%) had Medicare. Patients with an unfavorable insurance status (Medicaid/uninsured) were at a more advanced stage, had higher comorbidity scores, had B symptoms, and were in a lower income/education quartile (all P < .01). These patients were less likely to receive radiotherapy and start chemotherapy promptly and were less commonly treated at academic/research centers (all P < .01). Patients with unfavorable insurance had a 5‐year OS of 54% versus 87% for those favorably insured (P < .01). When adjustments were made for covariates, an unfavorable insurance status was associated with significantly decreased OS (hazard ratio, 1.60; 95% confidence interval, 1.34‐1.91; P < .01). The unfavorable insurance status rate increased from 22.8% to 28.8% between 1998 and 2011.CONCLUSIONSThis study reveals that HL patients with Medicaid and uninsured patients have outcomes inferior to those of patients with more favorable insurance. Targeting this subset of patients with limited access to care may help to improve outcomes. Cancer 2015;121:3435–43. © 2015 American Cancer Society.
Zeolitic Core@Shell Adsorbents for the Selective Removal of Free Glycerol from Crude Biodiesel
Authors: Masoumifard Nima , Arnal Pablo M. , Kaliaguine Serge , Kleitz Freddy 
Published: June 2015

AbstractSelective adsorption of free glycerol from crude biodiesel was investigated by using mesoporous silica spheres coated with a thin shell of microporous silicalite‐1. A polycrystalline silicalite‐1 shell was formed upon first covering the external surfaces of various core templates with discrete silicalite‐1 nanocrystals, and this was followed by short hydrothermal treatment to ensure shell uniformity. Batch glycerol adsorption experiments were conducted to evaluate the ability of the sorbents to remove free glycerol selectively from crude biodiesel mixtures at various temperatures, also in comparison to that of conventional sorbents, for example, bare mesoporous silica gel spheres and zeolites. The silicalite‐1 shell provided a microporous membrane that hindered the diffusion of fatty acid methyl esters into the mesopores of the composite sorbent, whereas the large pore volume of the mesoporous core enabled multilayer glycerol adsorption; this ultimately substantially enhanced the performance in terms of purification yield and adsorption capacity.
A Computational Comparison of Oxygen Atom Transfer Catalyzed by Dimethyl Sulf­oxide Reductase with Mo and W
Authors: Li Jilai , Andrejić Milica , Mata Ricardo A. , Ryde Ulf 
Published: June 2015

AbstractA thorough computational study has been performed to investigate oxygen atom transfer (OAT) reactions catalyzed by dimethyl sulfoxide reductase (DMSOR) with a catalytic molybdenum or tungsten ion. Thirteen different density functional theory (DFT) methods have been employed to obtain structural parameters along the reaction pathway, and single‐point energies were computed with local correlation coupled‐cluster methods [LCCSD(T0)]. For both Mo and W, most DFT methods indicate that the enzyme follows a two‐step mechanism with a stable intermediate in which a DMSO molecule coordinates to the metal ion in the +IV oxidation state, and this is also confirmed by the LCCSD(T0) energies. The W‐substituted models have a 26–30 kJ/mol lower activation barrier for the OAT reaction, and the reaction is 63–70 kJ/mol more exothermic than that with Mo. Different DFT methods give widely different activation and reaction energies, which roughly depend on the amount of exact exchange in the method; these differences are also reflected in the structures, especially for the rate‐limiting transition state. Consequently, there is quite a large variation in energies and various energy corrections (thermal, solvation, dispersion, and relativistic; up to 39 kJ/mol) depending on which DFT method is used to obtain the geometries. Therefore, a mechanism predicted by a single method should be viewed with caution.
Reduction of downlink delay time for heterogeneous users in Fi‐Wi indoor networks
Authors: DebBarma D. 
Published: June 2015

AbstractUbiquitous presence of umpteen WiFi access points (AP) in indoor locations leads to massive degradation in effective data rates acquired by users. Indoor space contributes approximately 80%  of the data generated in today's world. Thus, radio resource management in indoor environment calls for immediate attention. Hybrid Fibre‐Wireless (Fi‐Wi) architecture for indoor has been proposed to combine the benefits of a huge bandwidth availability of fibre with the mobility offered by wireless access. In this paper, we propose a managed hybrid Fi‐Wi indoor network. It consists of fibre infrastructure emanating from central home communication controller. Radio‐over‐fibre technology is used to distribute the radio signals throughout the indoor space using cell access nodes (CANs) to cover the immediate periphery inside rooms. The biggest advantage of such architecture is the ease of managing centrally the indoor radio resources for guaranteeing a better Quality of Service amongst heterogeneous user. In this paper, we model the problem of CAN to AP assignment based on downlink transmission delay experienced by users. We propose a centralised assignment method based on the reduction of overall network downlink transmission delay. Using MATLAB simulations, we show that a massive 66% reduction in the maximum downlink delay time for non‐uniform distribution of heterogeneous users can be achieved. Finally, we prove the optimality of the centralised assignment algorithm using coalition game theory. Copyright © 2015 John Wiley & Sons, Ltd.
Analysis of asphaltene deposition, carbonate precipitation, and their cementation in depleted reservoirs during CO2injection
Authors: Khurshid Ilyas , Choe Jonggeun 
Published: June 2015

AbstractCarbon dioxide (CO2) injection in depleted oil reservoirs is a potential means of reducing CO2emissions. In this regard, CO2‐related formation damages are considered key technical and economical issues. When CO2is injected after water flooding, it can be stored by hydrodynamic trapping, dissolution, and mineral trapping. This process leads to the formation of carbonic acid, which may react and dissolve the carbonates. The precipitation of these carbonates can reduce oil productivity and CO2injectivity. In this study, we develop an analytical model to predict the amount of asphaltene deposition, rock dissolution, and their cementation. Primarily, we develop an analytical model that treats the asphaltene deposition and carbonate dissolution in radial geometry. Then, this model predicts cementation, which is evaluated to determine the effect of cementation on reservoir permeability. Finally the developed model is compared with experimental data and determined the factors affecting the cementation. From analyses of different cases, cementation is a few percent but its percentage increases with time. The results presented in this study indicate that the amount of cementation depends on asphaltene percentage, flow rate, flow period, and reservoir depth. The model assumes constant reservoir temperature and no capillary and gravity forces. However, these forces might increase asphaltene‐carbonate cementation in the reservoir.© 2015 Society of Chemical Industry and John Wiley & Sons, Ltd
XI. Management of paediatric and adult non‐Hodgkin lymphoma: what lessons can each teach the other?
Authors: Burkhardt Birgit , Lenz Georg 
Published: June 2015

AbstractIs there anything that we can learn from each other regarding paediatric and adult non‐Hodgkin Lymphoma (NHL) management? Do we treat the same patients? Are there differences in lymphoma biology in the different age groups? Are the procedures of decision making and the infrastructure comparable? Is the weighing of toxicity and outcome aspects in the benefit and risk assessments prior to treatment decisions comparable? Interestingly, the proportional distribution of the NHL subtypes and the spectrum of NHL occurring in children and adolescents differs significantly from that in adults. This observation might motivate biological studies aiming to elucidate the pathomechanisms of lymphomagenesis. Concerning NHL diagnosis and staging, the comparison of outcome data reported for paediatric and adult patient series is often impaired by the use of different staging systems. However, the impact of reference laboratories supporting correct subtyping and the advantages of population‐based patient recruitment are experiences that might be transferable between paediatric and adult oncologists. Interestingly, the process of implementing new drugs into current treatment strategies and making these drugs available to patients varies substantially across patient's age groups. The far lower absolute number of patients, especially of relapsed patients, and the favorable outcome with current standard treatment may contribute to the marked differences in the kinetic of implementing new compounds comparing adult with paediatric NHL patients. Also, the basis for the conduction of cooperative clinical trials with pharmaceutical companies needs to be strengthened in paediatric clinical trial groups. In conclusion, both paediatric and adult oncologists benefit from the interdisciplinary discussion with each other, not only concerning results and experiences in clinical trials but also with respect to critical aspects of infrastructure.