bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sternal Morphologic Characteristics of U.S. Military Males by Computed Tomography: Implications for Intraosseous Access
Authors: Kaylor Ryan , Edwards Jared , Yue Ivan , Zarow Gregory J , Crane Anise , Boswell Gilbert , Auten Jonathan 
Published: August 2024

ABSTRACT

Introduction
Sternal intraosseous (IO) access has advantages over humeral and tibial access for fluid resuscitation in military medical settings due to superior flow rates and pharmacokinetics. However, the morphology of the young adult manubrial cortical and medullary bone as it relates to IO catheter tips of currently available FDA-approved IO access devices is unclear.

Materials and Methods
Computed tomography manubrium images of active duty service members (N = 93) aged 18 to 30 were assessed by radiologists, including manubrial height, width, and cortical thickness, as well as total thickness and medullary thickness at the thickest (superior) and thinnest (inferior) parts of the manubrium. Inference regarding medullary or cortical IO catheter tip placement rates were made for FAST1 (5.5 mm catheter depth) and TALON (4.5 mm catheter depth) sternal IO devices. Data were analyzed using ANOVA, non-parametric, and correlational statistics at P &lt; 0.05.

Results
As inferred from case-specific CT-derived manubrium dimensions and maximal catheter tip penetration depths, both FAST1 and TALON would be placed in the target medullary space on 100% of opportunities if properly applied in the superior manubrium and on 99% of opportunities if properly applied in the inferior manubrium. Age was not significantly related to IO-relevant manubrial dimensions.

Conclusions
Present findings suggest that both FAST1 and TALON sternal IO catheter tips can be successfully placed into the target medullary bone with high accuracy in male military members aged 18 to 30 who require rapid resuscitation.
Practice-Based Implementation Network: Behavioral Health Technician Optimization Pilot Lessons Learned
Authors: Libretto Salvatore , Edwards-Stewart Amanda , Kazi Asiya K , Narayanan-Pandit Surya , DeRoma Virginia , McLaughlin Elizabeth , Shank Lisa M 
Published: August 2024

ABSTRACT

Introduction
Between June 2021 and December 2022, the Practice-Based Implementation (PBI) Network conducted a pilot to study the optimization of behavioral health technicians (BHTs) within military behavioral health (BH) care system specialty BH clinics. Behavioral health technicians are paraprofessionals found in all branches of the military, and with training across a variety of clinic functions. Behavioral health technicians support BH specialty providers in many clinic functions (i.e., administrative, case management, clinical, and outreach). The primary aim of the BHT optimization pilot was to increase BHTs’ involvement in clinical care.

Materials and Methods
Four military BH outpatient clinics participated in the BHT optimization pilot. Participants from the 4 clinics included 12 BHTs, 3 providers, 3 internal facilitators, and 3 dual-role providers/internal facilitators. The pilot asked each clinic to assess their BHT utilization needs, and then barriers and facilitators to BHT optimization were addressed by creating site-specific BHT optimization plans.

Results
The degree to which clinic optimization of BHTs impacts provider workload, clinic capability or capacity, and patient access to evidence-based care could not be determined during the BHT optimization pilot. However, individualized clinic BHT optimization plans and strategies appeared to be feasible and acceptable methods for military health system BH clinics to optimize BHTs’ clinical skills. Lessons learned from this pilot included that: (1) clinics should consider establishing and maintaining action plans with specific, actionable goals for use of BHTs, and (2) BHT supervision, training, and clinic processes supporting optimization should be prioritized despite time constraints.

Conclusion
Overall, individualized clinic BHT optimization plans and strategies appear to be feasible and acceptable methods for military health system BH clinics to optimize BHTs’ clinical skills.
Using Physiological Biomarkers to Optimize Management of TBI in Austere Environments
Authors: Moberg Dick , Moyer Ethan , Gomba Alec , Willner Meghan , Keenan Sean , Jarema Dennis 
Published: August 2024

ABSTRACT

Introduction
Multimodal monitoring is the use of data from multiple physiological sensors combined in a way to provide individualized patient management. It is becoming commonplace in the civilian care of traumatic brain-injured patients. We hypothesized we could bring the technology to the battlefield using a noninvasive sensor suite and an artificial intelligence-based patient management guidance system.

Methods
Working with military medical personnel, we gathered requirements for a hand-held system that would adapt to the rapidly evolving field of neurocritical care. To select the optimal sensors, we developed a method to evaluate both the value of the sensor’s measurement in managing brain injury and the burden to deploy that sensor in the battlefield. We called this the Value-Burden Analysis which resulted in a score weighted by the Role of Care. The Value was assessed using 7 criteria, 1 of which was the clinical value as assessed by a consensus of clinicians. The Burden was assessed using 16 factors such as size, weight, and ease of use. We evaluated and scored 17 sensors to test the assessment methodology. In addition, we developed a design for the guidance system, built a prototype, and tested the feasibility.

Results
The resulting architecture of the system was modular, requiring the development of an interoperable description of each component including sensors, guideline steps, medications, analytics, resources, and the context of care. A Knowledge Base was created to describe the interactions of the modules. A prototype test set-up demonstrated the feasibility of the system in that simulated physiological inputs would mimic the guidance provided by the current Clinical Practice Guidelines for Traumatic Brain Injury in Prolonged Care (CPG ID:63). The Value-Burden analysis yielded a ranking of sensors as well as sensor metadata useful in the Knowledge Base.

Conclusion
We developed a design and tested the feasibility of a system that would allow the use of physiological biomarkers as a management tool in forward care. A key feature is the modular design that allows the system to adapt to changes in sensors, resources, and context as well as to updates in guidelines as they are developed. Continued work consists of further validation of the concept with simulated scenarios.
Performance During a Task That Simulates Passive Sonar Operator Duties Under Conditions of Varying Workloads
Authors: Peltier Chad , Guillory Sylvia , Bolkhovsky Jeffrey , Gever David , DeBrodt Dawn , Diaz Krystina 
Published: August 2024

ABSTRACT

Introduction
It is critical to develop and implement lab-based computer experiments that simulate real-world tasks in order to characterize operational requirements and challenges or identify potential solutions. Achieving a high degree of laboratory control, operational generalizability, and ease-of-use for a task is challenging, often leading to the development of tasks that can satisfy some facets but not all. This can result in insufficient solutions that leave real-world stakeholders with unsolved problems.

Materials and Methods
This issue is addressed using a customized passive sonar simulator application that provides extensive researcher control over the design and manipulation of a sonar task; a visual appearance and cognitive demand similar to a true submarine-based sonar task; and a convenient and short training routine for sonar novices. The task requires participants to watch for multiple signal sources of varying appearance and salience and subsequently classify these signals into their respective categories.

Results
The current study investigated the effects of stimulus signal strength and signal density on sonar task performance—including metrics of classification accuracy, classification confidence, and response times—finding an interaction between signal density and signal strength that resulted in greater performance errors with high signal density at the weakest signal strength.

Conclusions
The lab-based sonar application provides new possibilities for research, not limited to signal intensity and signal density but also through the manipulation of parameters such as the number of unique targets, target appearance, and task duration. This application may illuminate the operational demands that each of these factors may have on operator behavior within the dynamic tasks.
Sleep Behavior in Royal Australian Navy Shift Workers by Shift and Exposure to the SleepTank App
Authors: Devine Jaime K , Cooper Nadine , Choynowski Jake , Hursh Steven R 
Published: August 2024

ABSTRACT

Introduction
Rotating shiftwork schedules are known to disrupt sleep in a manner that can negatively impact safety. Consumer sleep technologies (CSTs) may be a useful tool for sleep tracking, but the standard feedback provided by CSTs may not be salient to shift-working populations. SleepTank is an app that uses the total sleep time data scored by a CST to compute a percentage that equates hours of sleep to the fuel in a car and warns the user to sleep when the “tank” is low. Royal Australian Navy aircraft maintenance workers operating on a novel rotational shift schedule were given Fitbit Versa 2s to assess sleep timing, duration, and efficiency across a 10-week period. Half of the participants had access to just the Fitbit app while the other half had access to Fitbit and the SleepTank app. The goal of this study was to evaluate differences in sleep behavior between shifts using an off-the-shelf CST and to investigate the potential of the SleepTank app to increase sleep duration during the 10-week rotational shift work schedule.

Materials and Methods
Royal Australian Navy volunteers agreed to wear a Fitbit Versa 2 with the SleepTank app (SleepTank condition), or without the SleepTank app (Controls), for up to 10 weeks from May to July 2023 during the trial of a novel shift rotation schedule. Participants from across 6 units worked a combination of early (6:00 AM to 2:00 PM), day (7:30 AM to 4:30 PM), late (4:00 PM to 12:00 AM), and night shifts (12:00 AM to 6:00 AM) or stable day shifts (6:00 AM to 4:00 PM). Differences in sleep behavior (time in bed, total sleep time, bedtime, wake time, sleep efficiency [SE]) between conditions and shift types were tested using Analysis of Variance. This study was approved by the Australian Departments of Defence and Veterans’ Affairs Human Research Ethics Committee.

Results
Thirty-four participants completed the full study (n = 17 Controls; n = 17 SleepTank). There was a significant effect of shift type on 24-hour time in bed (TIB24; F(4,9) = 8.15, P &lt; .001, η2 = 0.15) and total sleep time (TST24; F(4,9) = 8.54, P &lt; .001, η2 = 0.18); both were shorter in early shifts and night shifts compared to other shift types. TIB24 and TST24 were not significantly different between conditions, but there was a trend for greater SE in the SleepTank condition relative to Controls (F(1,9) = 2.99, P = .08, η2 = 0.11).

Conclusions
Sleep data collected by Fitbit Versa 2s indicated shorter sleep duration (TIB24, TST24) for Royal Australian Navy workers during early and late shifts relative to stable day shifts. Access to the SleepTank app did not greatly influence measures of sleep duration but may be protective against fatigue by affecting SE. Further research is needed to evaluate the utility of the SleepTank app as a means of improving sleep hygiene in real-world, shift-working environments.
Enhancing neuro-oncology care through equity-driven applications of artificial intelligence
Authors: Mehari Mulki , Sibih Youssef , Dada Abraham , Chang Susan M , Wen Patrick Y , Molinaro Annette M , Chukwueke Ugonma N , Budhu Joshua A , Jackson Sadhana , McFaline-Figueroa J Ricardo , Porter Alyx , Hervey-Jumper Shawn L 
Published: August 2024

Abstract
The disease course and clinical outcome for brain tumor patients depend not only on the molecular and histological features of the tumor but also on the patient’s demographics and social determinants of health. While current investigations in neuro-oncology have broadly utilized artificial intelligence (AI) to enrich tumor diagnosis and more accurately predict treatment response, postoperative complications, and survival, equity-driven applications of AI have been limited. However, AI applications to advance health equity in the broader medical field have the potential to serve as practical blueprints to address known disparities in neuro-oncologic care. In this consensus review, we will describe current applications of AI in neuro-oncology, postulate viable AI solutions for the most pressing inequities in neuro-oncology based on broader literature, propose a framework for the effective integration of equity into AI-based neuro-oncology research, and close with the limitations of AI.
Crystal Resorption as a Driver for Mush Maturation: an Experimental Investigation
Authors: Mangler Martin F , Humphreys Madeleine C S , Iveson Alexander A , Cooper Kari M , Clynne Michael A , Lindoo Amanda , Brooker Richard A , Wadsworth Fabian B 
Published: August 2024

Abstract
The thermal state of a magma reservoir controls its physical and rheological properties: at storage temperatures close to the liquidus, magmas are dominated by melt and therefore mobile, while at lower temperatures, magmas are stored as a rheologically locked crystal network with interstitial melt (crystal mush). Throughout the lifetime of a magmatic system, temperature fluctuations drive transitions between mush-dominated and melt-dominated conditions. For example, magma underplating or magma recharge into a crystal mush supplies heat, leading to mush disaggregation and an increase in melt fraction via crystal resorption, before subsequent cooling reinstates a crystal mush via crystal accumulation and recrystallisation. Here, we examine the textural effects of such temperature-driven mush reprocessing cycles on the crystal cargo. We conducted high-P-T resorption experiments during which we nucleated, grew, resorbed, and recrystallised plagioclase crystals in a rhyolitic melt, imposing temperature fluctuations typical for plumbing systems in intermediate arc volcanoes (20–40 °C). The experiments reproduce common resorption textures and show that plagioclase dissolution irreversibly reduces 3D crystal aspect ratios, leading to more equant shapes. Comparison of our experimental results with morphologies of resorbed and unresorbed plagioclase crystals from Mount St. Helens (MSH) (USA) reveals a consistent trend in natural rocks: unresorbed plagioclase crystals (found in MSH dacite, basalt and quenched magmatic inclusions [QMIs]) have tabular shapes, while plagioclase crystals with one or more resorption horizons (found in MSH dacite, QMIs, and mush inclusions) show more equant shapes. Plagioclase crystals showing pervasive resorption (found in the dacite and mush inclusions) have even lower aspect ratios. We therefore suggest that crystal mush maturation results in progressively more equant crystal shapes: the shapes of plagioclase crystals in a magma reservoir will become less tabular every time they are remobilised and resorbed. This has implications for magma rheology and, ultimately, eruptibility, as crystal shape controls the maximum packing fraction and permeability of a crystal mush. We hypothesise that a mature mush with more equant crystals due to multiple resorption–recrystallisation events will be more readily remobilised than an immature mush comprising unresorbed, tabular crystals. This implies that volcanic behaviour and pre-eruptive magmatic timescales may vary systematically during thermal maturation of a crustal magmatic system, with large eruptions due to rapid wholesale remobilisation of mushy reservoirs being more likely in thermally mature systems.
Wheat MYOSIN-RESEMBLING CHLOROPLAST PROTEIN controls B-type starch granule initiation timing during endosperm development
Authors: Chen Jiawen , Chen Yi , Watson-Lazowski Alexander , Hawkins Erica , Barclay J Elaine , Fahy Brendan , Denley Bowers Robin , Corbin Kendall , Warren Frederick J , Blennow Andreas , Uauy Cristobal , Seung David 
Published: August 2024

Abstract
Molecular factors that contribute to the diverse spatial and temporal patterns of starch granule initiation between species and organs are poorly understood. Wheat (Triticum sp.) endosperm contains both large A-type granules initiated during early grain development and small B-type granules that initiate about 10 to 15 days later. Here, we identify that the MYOSIN-RESEMBLING CHLOROPLAST PROTEIN (MRC) is required for the correct timing of B-type granule initiation in wheat endosperm during grain development. MRC is expressed in the endosperm exclusively in early grain development, before B-type granule initiation. We isolated three independent TILLING mutants of tetraploid wheat (Triticum turgidum cv. ‘Kronos’) with premature stop or missense mutations in the A-genome homeolog, which we showed to be the only active homeolog in tetraploid wheat due to a disruption of the B-genome homeolog. The mrc mutants had significantly smaller A-type granules and a higher relative volume of B-type granules in the endosperm than the wild type. Whereas B-type granules initiated 15 to 20 days post-anthesis (dpa) in the wild type, they appeared as early as 10 dpa in the mrc-1 mutant. These results suggest a temporal role for MRC in repressing B-type granule initiation, providing insight into how the distinct biochemical mechanisms that control A- and B-type granule initiation are regulated. This role of MRC in the wheat endosperm is distinct from the previously described role of Arabidopsis (Arabidopsis thaliana) MRC in promoting granule initiation in leaves, providing an example of functional diversification among granule initiation proteins.
Hypoxia represses pattern-triggered immune responses in Arabidopsis
Authors: Mooney Brian C , Doorly Catherine M , Mantz Melissa , García Pablo , Huesgen Pitter F , Graciet Emmanuelle 
Published: August 2024

Abstract
Biotic and abiotic stresses frequently co-occur in nature, yet relatively little is known about how plants coordinate the response to combined stresses. Protein degradation by the ubiquitin/proteasome system is central to the regulation of multiple independent stress response pathways in plants. The Arg/N-degron pathway is a subset of the ubiquitin/proteasome system that targets proteins based on their N-termini and has been specifically implicated in the responses to biotic and abiotic stresses, including hypoxia, via accumulation of group VII ETHYLENE RESPONSE FACTOR (ERF-VII) transcription factors that orchestrate the onset of the hypoxia response program. Here, we investigated the role of the Arabidopsis (Arabidopsis thaliana) Arg/N-degron pathway in mediating the crosstalk between combined abiotic and biotic stresses using hypoxia treatments and the flg22 elicitor of pattern-triggered immunity (PTI), respectively. We uncovered a link between the plant transcriptional responses to hypoxia and flg22. Combined hypoxia and flg22 treatments showed that hypoxia represses the flg22 transcriptional program, as well as the expression of pattern recognition receptors, mitogen-activated protein kinase (MAPK) signaling and callose deposition during PTI through mechanisms that are mostly independent from the ERF-VIIs. These findings improve our understanding of the tradeoffs between plant responses to combined abiotic and biotic stresses in the context of our efforts to increase crop resilience to global climate change. Our results also show that the well-known repressive effect of hypoxia on innate immunity in animals also applies to plants.
Chromosome-specific painting reveals the Y genome origin and chromosome rearrangements of the St genome in Triticeae
Authors: Chen Chen , Zhang Xuan , Li Yuling , Zou Bingcan , Xiao He , Han Yangshuo , Yang Xunzhe , Wu Dandan , Sha Lina , Yang Cairong , Liu Songqing , Cheng Yiran , Wang Yi , Kang Houyang , Fan Xing , Zhou Yonghong , Zhang Peng , Chen Zhong-Hua , Zhang Tao , Zhang Haiqin 
Published: August 2024

Abstract
Karyotypes provide key cytogenetic information on phylogenetic relationships and evolutionary origins in related plant species. The St genome of Pseudoroegneria contributes to 8 alloploid genera, representing over half of the species that are highly valuable for wheat (Triticum aestivum) breeding and for understanding Triticeae species evolution. However, St chromosome characterization is challenging due to limited cytogenetic markers and DNA information. We developed a complete set of St genome-specific chromosome painting probes for identification of the individual chromosomes 1St to 7St based on the genome sequences of Pseudoroegneria libanotica and wheat. We revealed the conservation of St chromosomes in St-containing species by chromosome painting, including Pseudoroegneria, Roegneria, Elymus, and Campeiostachys. Notably, the Y genome showed hybridization signals, albeit weaker than those of the St genome. The awnless species harboring the Y genome exhibited more intense hybridization signals compare to the awned species in Roegneria and Campeiostachys, yet weaker than the hybridization signals of the St genome in autotetraploid Pseudoroegneria strigosa. Although awnless species were morphologically more similar to each other, phenotypic divergence progressively increased from awnless to awned species. Our results indicate that the Y genome originated from the St genome and shed light on the possible origin of the Roegneria and Campeiostachys species, enhancing our understanding of St-genome-containing species evolution.
Having a granddaughter and voting for female candidates
Authors: Yamamura Eiji 
Published: August 2024

Abstract
This study examines the influence of grandchildren’s sex on grandparents’ voting behaviour by using independently collected individual-level data. The survey was conducted immediately after the 2016 House of Councillors election in Japan. It was found that individuals who had a granddaughter were more likely to vote for female candidates by a 10 per cent margin compared to those who did not. However, having a daughter did not affect parents’ voting behaviour. Furthermore, having a son or grandson also did not influence grandparents’ voting behaviour. This finding implies that grandparents vote with their granddaughters’ future benefits in mind, because granddaughters may be too young to vote in a male-dominated and ageing society.