bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protonation‐Assisted Conjugate Addition of Axially Chiral Enolates: Asymmetric Synthesis of Multisubstituted β‐Lactams from α‐Amino Acids
Authors: Yoshimura Tomoyuki , Takuwa Masatoshi , Tomohara Keisuke , Uyama Makoto , Hayashi Kazuhiro , Yang Pan , Hyakutake Ryuichi , Sasamori Takahiro , Tokitoh Norihiro , Kawabata Takeo 
Published: October 2012

Abstractβ‐Lactams with contiguous tetra‐ and trisubstituted carbon centers were prepared in a highly enantioselective manner through 4‐exo‐trig cyclization of axially chiral enolates generated from readily available α‐amino acids. Use of a weak base (metal carbonate) in a protic solvent (EtOH) is the key to the smooth production of β‐lactams. Use of the weak base is expected to generate the axially chiral enolates in a very low concentration, which undergo intramolecular conjugate addition without suffering intermolecular side reactions. Highly strained β‐lactam enolates thus formed through reversible intramolecular conjugate addition (4‐exo‐trig cyclization) of axially chiral enolates undergo prompt protonation by EtOH in the reaction media (not during the work‐up procedure) to give β‐lactams in up to 97 % ee.
M4(CH2)4 Cubane‐Type Rare‐Earth Methylidene Complexes: Unique Reactivity toward Unsaturated CO, CN, and CS Bonds
Authors: Li Tingting , Nishiura Masayoshi , Cheng Jianhua , Li Yang , Hou Zhaomin 
Published: October 2012

AbstractThe reactivity of the cubane‐type rare‐earth methylidene complex [Cp′Lu(μ3‐CH2)]4 (1, Cp′=C5Me4SiMe3) with various unsaturated electrophiles was investigated. The reaction of 1 with CO (1 atm) at room temperature gave the bis(ketene dianion)/dimethylidene complex [Cp′4Lu4(μ3‐CH2)2(μ3,η2‐O‐CCH2)2] (2) in 86 % yield through the insertion of two molecules of CO into two of the four lutetium–methylidene units. In the reaction with the sterically demanding N,N‐diisopropylcarbodiimide at 60 °C, only one of the four methylidene units in 1 reacted with one molecule of the carbodiimide substrate to give the mono(ethylene diamido)/trimethylidene complex [Cp′4Lu4(μ3‐CH2)3{iPrNC(=CH2)NiPr}] (3) in 83 % yield. Similarly, the reaction of 1 with phenyl isothiocyanate gave the ethylene amido thiolate/trimethylidene complex [Cp′4Lu4(μ3‐CH2)3{PhNC(S)=CH2}] (4). In the case of phenyl isocyanate, two of the four methylidene units in 1 reacted with four molecules of the substrate at ambient temperature to give the malonodiimidate/dimethylidene complex [Cp′4Lu4(μ3‐CH2)2{PhN=C(O)CH2(O)CNPh}2] (5) in 87 % yield. In this reaction, each of the two lutetium–methylidene bonds per methylidene unit inserted one molecule of phenyl isocyanate. All the products have been fully characterized by NMR spectroscopy, X‐ray diffraction, and microelemental analyses.
ChemInform Abstract: Structure Refinement and Two‐Center Luminescence of Ca3La3(BO3)5:Ce3+ under VUV—UV Excitation.
Authors: Liu Chunmeng , Liang Hongbin , Kuang Xiaojun , Zhong Jiuping , Sun Shuaishuai , Tao Ye 
Published: October 2012

AbstractCa3La3(1‐x)Ce3x(BO3)5 (x = 0, 0.01, 0.04, 0.10, 0.30, 0.50) phosphors are synthesized by solid state reaction of CaCO3, H3BO3, CeO2, and La2O3 (CO atmosphere, 1100 °C, 10 h).
ChemInform Abstract: Experimental and Computational Study of a New Wheel‐Shaped {[W5O21]3 [(UVIO2)2(μ‐O2)] 3}30‐ Polyoxometalate.
Authors: Miro Pere , Ling Jie , Qiu Jie , Burns Peter C. , Gagliardi Laura , Cramer Christopher J. 
Published: October 2012

AbstractNa6Li24{[W5O21]3 [(UO2)2(O2)]3} is synthesized by slow evaporation of an aqueous solution containing UO2(NO3)2, H3PW12O40, H2O2, LiOH, and NaOH (initial pH 8.8, 8% yield).
ChemInform Abstract: Ultrasonic‐Assisted Surfactant‐Free Synthesis of Highly Magnetized FeCo Alloy Nanocrystallite from Ferric and Cobalt Salt.
Authors: Wei Xian‐Wen , Wu Kong‐Lin , Zhu Guo‐Xing , Liu Yuan‐Jun , Shi Wei , Li Xiang‐Zi , Rong Lu‐Lu , Chen Le , Wu Fang‐Hui 
Published: October 2012

AbstractCrystalline Fe64Co36 (44% yield), Fe59Co41 (80% yield), and Fe37Co63 (86% yield) nanoparticles with diameters of 5—12 nm are synthesized by addition of N2H4 and NaOH to aqueous solutions of CoCl2 and FeCl3 with various Fe3+:Co2+ ratios at room temperature (Ar, ultrasonication, 343 K, 3 h).
ChemInform Abstract: Synthesis and Characterization of the Crystal Structure and Magnetic Properties of the New Fluorophosphate LiNaCo[PO4]F.
Authors: Ben Yahia Hamdi , et al. et al. 
Published: October 2012

AbstractThe new title compound is synthesized by solid state reaction of a stoichiometric mixture of LiF and NaCoPO4 (air, Pt crucible, 700 °C, 12 h).
ChemInform Abstract: Syntheses and Magnetic Properties Study of Isostructural BiM2BP2O10 (M: Co, Ni) Containing a Quasi‐1D Linear Chain Structure.
Authors: Zhang Wei‐Long , He Zhang‐Zhen , Xia Tian‐Long , Luo Zhong‐Zhen , Zhang Hao , Lin Chen‐Sheng , Cheng Wen‐Dan 
Published: October 2012

AbstractThe title compounds are quantitatively prepared by solid state reaction of Bi2O3, Co(OAc)2 or Ni(HCO2)2, H3BO3, and NH4H2PO4 in a molar ratio of 1:4:2:4 (1123 or 1193 K, 30 h).
ChemInform Abstract: Enantio‐ and Diastereoselective Hetero‐Diels—Alder Reactions Between 2‐Aza‐3‐silyloxy‐1,3‐butadienes and Aldehydes Catalyzed by Chiral Dirhodium(II) Carboxamidates.
Authors: Watanabe Yudai , Washio Takuya , Krishnamurthi Janagiraman , Anada Masahiro , Hashimoto Shunichi 
Published: October 2012

AbstractThe first catalytic asymmetric hetero‐Diels—Alder reaction between 2‐aza‐3‐siloxybutadienes and aldehydes is achieved using a complex dirhodium (II) catalyst.
ChemInform Abstract: Palladium‐Catalyzed Synthesis of 2‐Amino Ketones from Propargylic Carbonates and Secondary Amines.
Authors: Cacchi Sandro , Fabrizi Giancarlo , Filisti Eleonora , Goggiamani Antonella , Iazzetti Antonia , Maurone Loredana 
Published: October 2012

AbstractThe novel simple and clean title synthesis of the title compounds from readily available starting materials involves a formal anti‐Markovnikov addition of water to the C‐C triple bond.
ChemInform Abstract: First Example of a Heterobimetallic “Pd—Sn” Catalyst for Direct Activation of Alcohol: Efficient Allylation, Benzylation and Propargylation of Arenes, Heteroarenes, Active Methylenes and Allyl‐Si Nucleophiles.
Authors: Das Debjit , Pratihar Sanjay , Roy Ujjal Kanti , Mal Dipakranjan , Roy Sujit 
Published: October 2012

AbstractA highly efficient, very selective, mild, air and water stable catalyst for direct alkylation of various carbon nucleophiles with a wide variety of π‐activated alcohols is presented.
ChemInform Abstract: Bis(perfluorooctanesulfonyl)imide Supported on Fluorous Silica Gel: Application to Protection of Carbonyls.
Authors: Hong Mei , Xiao Guomin 
Published: October 2012

AbstractThe immobilization of bis(perfluorooctanesulfonyl)imide on fluorous silica gel and its utilization in protection of aldehydes and ketones (I) as acetals and ketals (III) and (V) is described.
ChemInform Abstract: Side‐Arm‐Promoted Highly Enantioselective Ring‐Opening Reactions and Kinetic Resolution of Donor—Acceptor Cyclopropanes with Amines.
Authors: Zhou You‐Yun , Wang Li‐Jia , Li Jun , Sun Xiu‐Li , Tang Yong 
Published: October 2012

AbstractSpecial emphasis is given for the choice of ligand (I) which supports the complexation and activation of the cyclopropane by interfering with the concommitant coordination of the amine.
ChemInform Abstract: Gold‐Catalyzed Ring Expansions of 1‐Alkynylcyclobutanol Derivatives via Tandem Hydration and α‐Ketol Rearrangement.
Authors: Kim Ki‐Dae , Yeom Hyun‐Suk , Shin Sunwoong , Shin Seunghoon 
Published: October 2012

AbstractThe process is optimized to yield mostly α‐hydroxycylopentanones.
ChemInform Abstract: Expanding the Scope of Arylsulfonylacetylenes as Alkynylating Reagents and Mechanistic Insights in the Formation of Csp2—Csp and Csp3—Csp Bonds from Organolithiums.
Authors: Garcia Ruano Jose Luis , Aleman Jose , Marzo Leyre , Alvarado Cuauhtemoc , Tortosa Mariola , Diaz‐Tendero Sergio , Fraile Alberto 
Published: October 2012

AbstractThe reaction of organolithium compounds with arylsulfonylacetylenes gives alkynes through addition followed by elimination of the sulfone group.
ChemInform Abstract: A Liquid—Liquid Biphasic Homogeneous Organocatalytic Aldol Protocol Based on the Use of a Silica Gel Bound Multilayered Ionic Liquid Phase.
Authors: Montroni Elisa , Lombardo Marco , Quintavalla Arianna , Trombini Claudio , Gruttadauria Michelangelo , Giacalone Francesco 
Published: October 2012

AbstractKey feature of the title protocol is the use of a cis‐ion‐tagged proline dissolved in a liquid film on a multilayered ionic liquid covalently bound to silica. The resulting catalytically active material is soaked in cyclohexanone and water to form a semi‐transparent gel which then reacts with the aldehyde.
ChemInform Abstract: Hypervalent Iodine Mediated Synthesis of Carbamate Protected p‐Quinone Monoimine Ketals and p‐Benzoquinone Monoketals.
Authors: Bodipati Naganjaneyulu , Peddinti Rama Krishna 
Published: October 2012

AbstractThe new and facile method for the synthesis of the title compounds from a single starting material is reported.
ChemInform Abstract: Enantioselective Iridium‐Catalyzed Hydrogenation of α‐Arylcinnamic Acids and Synthesis of (S)‐Equol.
Authors: Yang Shuang , Zhu Shou‐Fei , Zhang Can‐Ming , Song Song , Yu Yan‐Bo , Li Shen , Zhou Qi‐Lin 
Published: October 2012

AbstractThe use of indium catalyst (I) mostly allows the hydrogenation of α‐arylcinnamic acids under ambient pressure and low loading to afford propionic acid derivatives with excellent enantioselectivities.
ChemInform Abstract: The Ligand and Base‐Free Pd‐Catalyzed Oxidative Heck Reaction of Arylboronic Acids and Olefins.
Authors: Sun Peng , Zhu Yan , Yang Hailong , Yan Hong , Lu Linhua , Zhang Xiang , Mao Jincheng 
Published: October 2012

AbstractMany different types of substrates including organoboronic reagents and an organosilicon reagent, e.g. (IX), are tolerated in the highly effective title reaction.
ChemInform Abstract: Rh(II)‐Catalyzed [2,3]‐Sigmatropic Rearrangement of Sulfur Ylides Derived from N‐Tosylhydrazones and Sulfides.
Authors: Li Yuye , Huang Zhongxing , Wu Xinhu , Xu Peng‐Fei , Jin Jing , Zhang Yan , Wang Jianbo 
Published: October 2012

AbstractA broad spectrum of homoallylic sulfides and some related allenes (XIII) is prepared.
ChemInform Abstract: Asymmetric Conjugate Addition of Thioglycolate to a Range of Chalcones Using Tetrahydroisoquinoline (TIQ) N,N′‐Dioxide Ligands.
Authors: Chakka Sai Kumar , Cele Zamani E. D. , Sosibo Sphelele C. , Francis Vivian , Arvidsson Per I. , Kruger Hendrik G. , Maquire Glenn E. M. , Govender Thavendran 
Published: October 2012

AbstractThe presented ligand shows the best activity of the novel synthesized ligands for the title reaction.
ChemInform Abstract: Chiral SO/P Hybrid Ligands: An Enantioselective Switch in Palladium‐Catalyzed Asymmetric Allylic Etherifications.
Authors: Xing Junwei , Cao Peng , Liao Jian 
Published: October 2012

AbstractThe absolute configuration of the product can be controlled by the phosphorus substituents of the ligand.
ChemInform Abstract: Facile Synthesis of Lipophilic δ‐Amino Acid Conjugates from 4‐Alkoxy‐dithionaphthoic Acids.
Authors: Worth Anna C. , Needham Catherine E. , Franklin Donald B. , Lampkins Andrew J. 
Published: October 2012

AbstractKey features of the synthesis of novel dithionaphthoic acid derivatives (X) are the acylation of in situ generated Grignard reagents [from bromides (III)] with carbon disulfide and the chemoselective reaction of dithioesters (VII) with protected (VIII) or unprotected (XI) δ‐amino acids.
ChemInform Abstract: Straightforward Synthesis of Phenanthrenes from Styrenes and Arenes.
Authors: Li Hu , He Ke‐Han , Liu Jia , Wang Bi‐Qin , Zhao Ke‐Qing , Hu Ping , Shi Zhang‐Jie 
Published: October 2012

AbstractA simple two‐step method is elaborated for the preparation of phenanthrenes (IV), benzo[c]phenanthrenes (VII), and crysenes (IX) using a sequence of Heck‐type coupling and photocyclization.
ChemInform Abstract: Gold‐Catalyzed Synthesis of Substituted 2‐Aminofurans via Formal [4 + 1]‐Cycloadditions on 3‐En‐1‐ynamides.
Authors: Dateer Ramesh B. , Pati Kamalkishore , Liu Rai‐Shung 
Published: October 2012

AbstractThe reaction proceeds as well with 3‐en‐1‐ynamides who bear alternative withdrawing groups like tosyl instead of mesyl at the nitrogen.
ChemInform Abstract: Synthesis of Substituted Dihydrobenzofurans and Bis‐dihydrobenzofurans.
Authors: Chang Meng‐Yang , Lee Tein‐Wei , Wu Ming‐Hao 
Published: October 2012

AbstractVarious benzofuran derivatives, e.g. compounds (VII) and (XII), are prepared via an intramolecular debenzylative annulation as key step.
ChemInform Abstract: Copper‐Catalyzed Direct C—H Bond Oxidative Acetoxylation and Iodination of Indoles.
Authors: Ge Shao‐peng , Zhang Xiao‐hong , Han Jiang‐sheng , Zhong Ping 
Published: October 2012

AbstractVarious indol‐3‐yl acetates (III) and 3‐iodoindoles (IV) are obtained under optimized reaction conditions in nearly 1:1 ratio.
ChemInform Abstract: Intramolecular Hydrogen Bonding‐Assisted Cyclocondensation of α‐Diazoketones with Various Amines: A Strategy for Highly Efficient Wolff 1,2,3‐Triazole Synthesis.
Authors: Wang Zikun , Bi Xihe , Liao Peiqiu , Zhang Rui , Liang Yongjiu , Dong Dewen 
Published: October 2012

AbstractA convenient synthetic procedure is elaborated for the preparation of triazoles (III), (V), and (VI) by Wolff cyclocondensation reactions.
ChemInform Abstract: Synthesis and Anticonvulsant Activities of Some Triazolothiadiazole Derivatives.
Authors: Deng Xian‐Qing , Dong Zheng‐Qi , Song Ming‐Xia , Shu Bing , Wang Shi‐Ben , Quan Zhe‐Shan 
Published: October 2012

AbstractSynthesis and anticonvulsant activity of 6‐substituted [1,2,4]triazolo[3,4‐b][1,3,4]thiadiazole derivatives (III) and (V) are described.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Chromene Derivatives by Iminium Ion Catalysis.
Authors: Rueping Magnus , Merino Estibaliz , Sugiono Erli 
Published: October 2012

AbstractThe asymmetric cyclization of cyclic β‐diketones with α,β‐unsaturated aldehydes is efficiently catalyzed by diarylprolinol silyl ethers to afford hydroxychromenone derivatives, e.g. (III), in good yields and enantioselectivities.
ChemInform Abstract: Nickel(II) Chloride Hexahydrate as an Efficient Catalyst for the Preparation of Highly Functionalized Piperidine Derivatives.
Authors: Shafiee Mohammad Reza Mohammad , Najafabadi Batool Hojati , Ghashang Majid 
Published: October 2012

AbstractAn efficient three‐component cyclocondensation reaction of aldehydes, aromatic amines, and acetoacetic esters leading to highly functionalized piperidines (IV) under ambient conditions is presented.
ChemInform Abstract: Tetrahydroisoquinolines by Friedel—Crafts Cyclizations Promoted by Iron(III) Chloride Hexahydrate.
Authors: Bunce Richard A. , Cain Nicholas R. , Cooper John G. 
Published: October 2012

AbstractApplying more stringent Lewis acid catalysts such as Amberlyst 15 or aluminium chloride gives primarily loss of the alcohol‐bearing side‐chain.
ChemInform Abstract: A Novel Chemoselective Synthesis of 1,2‐Dihydroisoquinolines Linked to 2‐Thiohydantoins in Water
Authors: Ghanbari Mohammad Mehdi , Jamali Marzieh 
Published: October 2012

Abstractvia three‐component, one‐pot condensation of various isocyanides, isoquinoline, and thiohydantoins
ChemInform Abstract: Synthesis and Electrochemical Evaluation of Substituted Imidazo[4,5‐d]pyrrolo[3,2‐f][1,3]diazepine Scaffolds.
Authors: Zaki Magdi E. A. , Bettencourt A. Paula , Fernandes Francisco M. , Proenca M. Fernanda 
Published: October 2012

AbstractThe electrochemical properties of the title compounds in comparison to that of known physiologically active substances reveals compound (VII) as a promising anti‐cancer agent.
ChemInform Abstract: Lycobelines A—C, Novel C16N2‐Type Lycopodium Alkaloids from Huperzia goebelii.
Authors: Hirasawa Yusuke , Matsuya Ryo , Shaari Khozirah , Lajis Nordin Hj , Uchiyama Nahoko , Goda Yukihiro , Morita Hiroshi 
Published: October 2012

AbstractPreliminary investigations concerning cytotoxic effects reveal that the title compounds are inactive.
ChemInform Abstract: Nanoengineered Glycan Sensors Enabling Native Glycoprofiling for Medicinal Applications: Towards Profiling Glycoproteins Without Labeling or Liberation Steps
Authors: Reuel Nigel F. , Mu Bin , Zhang Jingqing , Hinckley Allison , Strano Michael S. 
Published: October 2012

AbstractReview: 208 refs.
Analysis and implementation of a soft switching DC/DC converter with three asymmetric PWM circuits
Authors: Lin Bor‐Ren , Chen Chih‐Chieh 
Published: October 2012

SUMMARYThis paper presents a soft switching converter with three buck‐type active clamp circuits (or asymmetric half‐bridge circuits) to achieve the functions of the low power rating on the transformers and power semiconductors and low current rating on the rectifier diodes and output inductors. Three half‐bridge circuits are stacked at the high voltage side to reduce the voltage stress of each power switch at one‐half of input voltage and connected in parallel at the low voltage side to share load current and reduce the current rating on each magnetic component and the rectifier diode. Thus, the size of the output chokes is reduced. In each half‐bridge converter, the asymmetric pulse‐width modulation is adopted to control power switches. Power MOSFETs can be turned on with zero voltage during the transition interval due to the resonant behavior by the output capacitance of MOSFETs and the leakage inductance (or external inductance) of transformers. Experiments based on a laboratory prototype with 1 kW rated power are provided to demonstrate the performance of proposed converter. Copyright © 2012 John Wiley & Sons, Ltd.
Catalytic One‐Pot Synthesis of 1‐Substituted 5,6,7,8‐Tetrahydroindolizine Derivatives
Authors: Biletzki Tobias , Imhof Wolfgang 
Published: October 2012

AbstractThe reaction of α,β‐unsaturated aldehydes, carbon monoxide, and but‐3‐en‐1‐amine in the presence of Ru3(CO)12 as a precatalyst yields 1‐substituted 5,6,7,8‐tetrahydroindolizine derivatives for a wide variety of groups R1 at the C‐3 position of the α,β‐unsaturated aldehyde.
Polymorphisms in pattern‐recognition genes in the innate immunity system and risk of non‐Hodgkin lymphoma
Authors: Hu Wei , Bassig Bryan A. , Xu Jun , Zheng Tongzhang , Zhang Yawei , Berndt Sonja I. , Holford Theodore R. , Hosgood H. Dean , Leaderer Brian , Yeager Meredith , Menashe Idan , Boyle Peter , Zou Kaiyong , Zhu Yong , Chanock Stephen , Lan Qing , Rothman Nathaniel 
Published: October 2012

AbstractThe pattern‐recognition pathway plays an important role in infection recognition and immune responses, and previous studies have suggested an association between genetic variation in innate immunity genes and non‐Hodgkin lymphoma (NHL). We evaluated NHL risk associated with genetic variation in pattern‐recognition genes using data from a case–control study of NHL conducted in Connecticut women. Single nucleotide polymorphisms (SNPs) in 27 pattern‐recognition genes were genotyped in 432 Caucasian incident NHL cases and 494 frequency‐matched controls. Unconditional logistic regression was used to compute odds ratios (ORs) for NHL and common NHL subtypes in relation to individual SNPs and haplotypes. A gene‐based analysis that adjusted for the number of tagSNPs genotyped in each gene showed a significant association with overall NHL for the MBP gene (P = 0.028), with the diffuse large B‐cell lymphoma (DLBCL) subtype for the MASP2 gene (P = 0.011), and with the follicular lymphoma (FL) subtype for DEFB126 (P = 0.041). A SNP‐based analysis showed that MBP rs8094402 was associated with decreased risks of overall NHL (allele risk OR = 0.72, P‐trend = 0.0018), DLBCL (allele risk OR = 0.72, P‐trend = 0.036), and FL (allele risk OR = 0.67, P‐trend = 0.021), while MASP2 rs12711521 was associated with a decreased risk of DLBCL (allele risk OR = 0.57, P‐trend = 0.0042). We also observed an increased risk of FL for DEFB126 rs6054706 (allele risk OR = 1.39, P‐trend = 0.033). Our results suggest that genetic variation in pattern‐recognition genes is associated with the risk of NHL or specific NHL subtypes, but these preliminary findings require replication in larger studies. Mol. Mutagen. 2013. © 2012 Wiley Periodicals, Inc.
High levels of transcription stimulate transversions at GC base pairs in yeast
Authors: Alexander Matthew P. , Begins Kaitlyn J. , Crall William C. , Holmes Margaret P. , Lippert Malcolm J. 
Published: October 2012

AbstractHigh‐levels of transcription through a gene stimulate spontaneous mutation rate, a phenomenon termed transcription‐associated mutation (TAM). While transcriptional effects on specific mutation classes have been identified using forward mutation and frameshift‐reversion assays, little is yet known about transcription‐associated base substitutions in yeast. To address this issue, we developed a new base substitution reversion assay (the lys2‐TAG allele). We report a 22‐fold increase in overall reversion rate in the high‐ relative to the low‐transcription strain (from 2.1‐ to 47‐ × 10−9). While all detectable base substitution types increased in the high‐transcription strain, G→T and G→C transversions increased disproportionately by 58‐ and 52‐fold, respectively. To assess a potential role of DNA damage in the TAM events, we measured mutation rates and spectra in individual strains defective in the repair of specific DNA lesions or null for the error‐prone translesion DNA polymerase zeta (Pol zeta). Results exclude a role of 8‐oxoGuanine, general oxidative damage, or apurinic/apyrimidinic sites in the generation of TAM G→T and G→C transversions. In contrast, the TAM transversions at GC base pairs depend on Pol zeta for occurrence implicating DNA damage, other than oxidative lesions or AP sites, in the TAM mechanism. Results further indicate that transcription‐dependent G→T transversions in yeast differ mechanistically from equivalent events in E. coli reported by others. Given their occurrences in repair‐proficient cells, transcription‐associated G→T and G→C events represent a novel type of transcription‐associated mutagenesis in normal cells with potentially important implications for evolution and genetic disease. Mol. Mutagen. 2013. © 2012 Wiley Periodicals, Inc.
Anorexia Nervosa and Low Weight EDNOS: A 10‐year Study of Service Consumption and Outcome in a Local Specialised Service for Adults
Authors: Wales Jackie , Brewin Nicola , Palmer Robert L 
Published: October 2012

AbstractA 10‐year retrospective case note study of adults with eating disorders at low weight examined levels of service consumption and the outcome in terms of body mass index. Records of 202 such patients, referred to a specialist secondary service, were studied. Just over one quarter of the patients failed to engage in treatment, attending five or fewer appointments. Of those who did engage, most were treated as out‐patients and had an average contact with the service of almost 2.5 years and 46 sessions. Only about one in six patients was admitted as an in‐patient at any time. These results suggest that most adults with eating disorder at low weight can be managed as out‐patients. However, service providers should expect prolonged contact and high service consumption. Copyright © 2012 John Wiley & Sons, Ltd and Eating Disorders Association.