bluuebunny/crossref_metadata_2025_split huggingface dataset:
Types of Stroke Recurrence in Patients with Ischemic Stroke: A Substudy from the PRoFESS Trial
Authors: Toni Danilo , Di Angelantonio Emanuele , Di Mascio Maria Teresa , Vinisko Richard , Bath Philip MW ,   for the PRoFESS Study Group
Published: October 2013

Background Risk profiles for stroke recurrence are poorly characterized. Aims We determined the variation in the risk and type of recurrent stroke among index ischemic stroke subtypes, and whether index stroke subtype and conventional stroke risk factors were predictors of stroke recurrence. Methods Patients enrolled in the Prevention Regimen for Effectively Avoiding Second Strokes trial were included in this study. Results In 1794 patients' recurrent stroke subtypes were the same as the index stroke in: 48·3% of patients with large artery atherothrombosis stroke; 50% of patients with cardioembolic stroke; 48·7% of patients with small artery occlusion stroke; 8·1% of patients with stroke of other etiology, and 45·3% of patients with undetermined etiology stroke. Patients with cardioembolic stroke, who were unwilling or unable to take oral anticoagulants, had the greatest risk of stroke recurrence. Predictors of stroke recurrence in multivariable analysis were: older age and previous stroke among large artery atherothrombosis strokes; older age, male sex, previous stroke, previous transient ischemic attack, hypertension, diabetes, and tobacco use among small artery occlusion strokes; older age among cardioembolic strokes; atrial fibrillation and anti-diabetic medications among other etiology strokes; older age, previous stroke and atrial fibrillation among undetermined etiology strokes. Predictors of brain hemorrhage as recurrent stroke were index small artery occlusion stroke, older age, previous stroke, and antiplatelet treatment with aspirin plus extended-release dipyridamole. Conclusions Risk predictors for stroke recurrence and for brain hemorrhage differ by index ischemic stroke subtype, information that is important when initiating secondary prevention therapy.
Incidence and Outcome of Cerebrovascular Events Related to Cervical Artery Dissection: The Dijon Stroke Registry
Authors: Béjot Yannick , Daubail Benoit , Debette Stéphanie , Durier Jérôme , Giroud Maurice 
Published: October 2013

Background Reliable epidemiological data on the true incidence of cerebrovascular events related to spontaneous cervical artery dissection, including stroke and transient ischemic attack, are scarce. Aims To evaluate the incidence, characteristics, and outcome of cerebrovascular events due to cervical artery dissection. Methods All cerebrovascular events (stroke and transient ischemic attack) occurring in Dijon, France, from 2006 to 2011, were retrieved from a population-based registry. Patients with a cervical artery dissection were identified. Incidence rates, baseline characteristics, and outcome at three-months were described. Results Among the 1368 patients with cerebrovascular events, 27 had cervical artery dissection (2·0%, 52% men, mean age 49·1 ± 17·1), including 10 patients with internal carotid artery dissection, 16 patients with vertebral artery dissection, and one patients with both internal carotid artery dissection and vertebral artery dissection. The crude incidence rate of cerebrovascular events due to cervical artery dissection was 2·97/100 000/ year. Corresponding rates were 1·21/100 000/year for internal carotid artery dissection, and 1·87/100 000/year for vertebral artery dissection. Seventy per cent of patients had a stroke and among these, higher severity was observed in those with internal carotid artery dissection. A good outcome (m-Rankin score 0–2) was observed in 89% of patients at three-months, whatever the location of the cervical artery dissection. One patient with vertebral artery dissection died at day 38. Conclusion The incidence of cerebrovascular events related to vertebral artery dissection is greater than previously reported, which may indicate a better identification of patients due to improvements in diagnostic procedures.
Disowned by the Ownership Society: How Native Americans Lost Their Land
Authors: Geisler Charles 
Published: October 2013

AbstractOver the past five centuries, Europeans have enclosed the global commons and, in the process, incorporated whole continents of aboriginal land. Some scholars argue that Indians in North America were spared the ravages of compulsory enclosure, having sold their land to non‐Indians through willing‐seller transactions and benefited from federal government trust and treaty policies. Moreover, where enclosure existed, it is widely believed to have ended as Indians converted to agriculture, thereby internalizing hard work, sedentary life styles, and allotted ownership. This study disputes such historical accounts and suggests a wave of new enclosures in accordance with recent U.S. Department of Agricultural minority lending policies. By discriminating against Native American farmers and ranchers, the federal government has enabled the erasure of title, livelihood opportunities, and cultural identity among Indian farming and ranching communities. Evidence from the Fort Berthold Reservation of North Dakota reveals the complex complicity of the federal government in Indian land erasure and points to a changing reservation geography that, even now, makes castaways of agrarian Indians.
Patient dose simulations for scanning‐beam digital x‐ray tomosynthesis of the lungs
Authors: Nelson Geoff , Yoon Sungwon , Krishna Ganesh , Wilfley Brian , Fahrig Rebecca 
Published: October 2013

Purpose:An improved method of image guidance for lung tumor biopsies could help reduce the high rate of false negatives. The aim of this work is to optimize the geometry of the scanning‐beam digital tomography system (SBDX) for providing real‐time 3D tomographic reconstructions for target verification. The unique geometry of the system requires trade‐offs between patient dose, imaging field of view (FOV), and tomographic angle.Methods:Tomosynthetic angle as a function of tumor‐to‐detector distance was calculated. Monte Carlo Software (PCXMC) was used to calculate organ doses and effective dose for source‐to‐detector distances (SDDs) from 90 to 150 cm, patient locations with the tumor at 20 cm from the source to 20 cm from the detector, and FOVs centered on left lung and right lung as well as medial and distal peripheries of the lungs. These calculations were done for two systems, a SBDX system and a GE OEC‐9800 C‐arm fluoroscopic unit. To evaluate the dose effect of the system geometry, results from PCXMC were calculated using a scan of 300 mAs for both SBDX and fluoroscopy. The Rose Criterion was used to find the fluence required for a tumor SNR of 5, factoring in scatter, air‐gap, system geometry, and patient position for all models generated with PCXMC. Using the calculated fluence for constant tumor SNR, the results from PCXMC were used to compare the patient dose for a given SNR between SBDX and fluoroscopy.Results:Tomographic angle changes with SDD only in the region near the detector. Due to their geometry, the source array and detector have a peak tomographic angle for any given SDD at a source to tumor distance that is 69.7% of the SDD assuming constant source and detector size. Changing the patient location in order to increase tomographic angle has a significant effect on organ dose distribution due to geometrical considerations. With SBDX and fluoroscopy geometries, the dose to organs typically changes in an opposing manner with changing patient location. When tumor SNR is held constant (i.e., x‐ray fluence is scaled appropriately), SBDX gives 2–10 times less dose than fluoroscopy for the same conditions within the typical range of patient locations. The relative position of the patient (as a percent of SDD) has a much more significant impact on dose than either SDD or patient position. The patient position providing the minimum dose for a given tumor SNR and SDD is approximately the same as the position of maximum tomographic angle.Conclusions:SBDX offers a significant dose advantage over currently used C‐arm fluoroscopy. The patient location with lowest dose coincides with the location of maximum tomographic angle. In order to provide adequate space for the patient and for the pulmonologists’ equipment, a SDD of 100 cm is recommended.
Abiraterone Acetate in Combination with Prednisone for the Treatment of Patients with Metastatic Castration-Resistant Prostate Cancer: U.S. Food and Drug Administration Drug Approval Summary
Authors: Kluetz Paul G. , Ning Yang-Min , Maher V. Ellen , Zhang Lijun , Tang Shenghui , Ghosh Debasis , Aziz Robeena , Palmby Todd , Pfuma Elimika , Zirkelbach Jeanne Fourie , Mehrotra Nitin , Tilley Amy , Sridhara Rajeshwari , Ibrahim Amna , Justice Robert , Pazdur Richard 
Published: October 2013

Abstract
On December 10, 2012, the U.S. Food and Drug Administration granted full approval for a modified indication for abiraterone acetate (Zytiga tablets; Janssen Biotech, Inc.) in combination with prednisone for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC). The approval was based on clinical trial COU-AA-302, which randomly allocated asymptomatic or mildly symptomatic patients with chemotherapy-naïve mCRPC and no visceral metastases to either abiraterone acetate plus prednisone (N = 546) or placebo plus prednisone (N = 542). The coprimary endpoints were radiographic progression-free survival (rPFS) and overall survival (OS). The median rPFS was 8.3 months in the placebo arm and had not yet been reached in the abiraterone acetate arm {HR, 0.43 [95% confidence interval (CI) 0.35–0.52]; P &lt; 0.0001}. A prespecified interim analysis demonstrated an improvement in OS favoring the abiraterone acetate arm [HR, 0.79 (95% CI, 0.66–0.96)] but did not cross the O'Brien-Fleming boundary for statistical significance. Safety data confirmed the known adverse reaction profile of abiraterone acetate. Full approval was granted on the basis of a large magnitude of effect on rPFS, a favorable trend in OS, and internal consistency across multiple secondary endpoints and exploratory patient-reported pain data. This is the first drug approval for mCRPC to use rPFS as the primary endpoint. Importantly, this approval was granted in the context of a prior statistically significant OS benefit that formed the basis of the original April 28, 2011, approval of abiraterone acetate for patients with mCRPC who had received prior chemotherapy containing docetaxel. Clin Cancer Res; 19(24); 6650–6. ©2013 AACR.
Limited Sinus Tarsi Approach for Intra-articular Calcaneus Fractures
Authors: Kikuchi Christian , Charlton Timothy P. , Thordarson David B. 
Published: October 2013

Background: Operative treatment of calcaneal fractures has a historically high rate of wound complications, so the most optimal operative approach has been a topic of investigation. This study reviews the radiographic and clinical outcomes of the use of the sinus tarsi approach for operative fixation of these fractures with attention to the rate of infection and restoration of angular measurements. Methods: The radiographs and charts of 20 patients with 22 calcaneal fractures were reviewed to assess for restoration of angular and linear dimensions of the calcaneus as well as time to radiographic union. Secondary outcome measures included the rate of postoperative infection, osteomyelitis, revision surgeries, and nonunion. Results: We found a statistically significant restoration of Böhler’s angle and calcaneal width. Three of the 22 cases had a superficial wound infection. One patient had revision surgery for symptomatic hardware removal. There were no events of osteomyelitis, deep infection, malunion, or nonunion. Conclusion: We found that the sinus tarsi approach yielded similar outcomes to those reported in the literature. Level of Evidence: Level IV, retrospective case series.
Upper Respiratory Tract Endoscopy in the Cat
Authors: Sobel David S 
Published: October 2013

Clinical challenges: Endoscopy of the feline upper respiratory tract has always taken a bit of a back seat to exploration of the canine nose and paranasal sinuses, pharynx and trachea, due to some anatomic limitations and lack of availability of appropriate-sized equipment. Practical relevance: With proper training, however, even the inexperienced endoscopist can find that endoscopy and endoscopic surgery can be of tremendous utility in feline practice. What had previously been largely off-limits sites, in terms of direct visualization and surgical intervention, the feline rhinarium, paranasal sinuses, pharynx and trachea are now anatomic areas that can be effectively visualized in most clinical scenarios. Moreover, endoscopic surgery is now an area gaining significant appreciation for its diagnostic and therapeutic benefits. Audience: This article will not serve as a complete treatise on disease processes of the upper respiratory tract in cats, but rather is intended as a technical and instructional reference point on upper airway endoscopy for veterinary surgeons, both in first opinion as well as referral small animal practice.
Erratum: 2013 AAFP Feline Vaccination Advisory Panel Report
Authors: Scherk M A , Ford R B , Gaskell R M , Hartmann K , Hurley K F , Lappin M R , Levy J K , Little S E , Nordone S K , Sparkes A H 
Published: October 2013

Regrettably, an error appeared in the ‘Injectable vaccine administration’ box on page 798: the pictures in Figures 8 and 9 were swapped with each other. ( The error appears in the printed copies of the journal, and in online versions downloaded before mid-October 2013.) The amended box is reproduced here in full. DOI of original article: 10.1177/1098612X13500429
Risk-assessment score for screening diabetes mellitus among Omani adults
Authors: D’Souza Melba S , Amirtharaj Anandhi , Venkatesaperumal Ramesh , Isac Chandrani , Maroof Samira 
Published: October 2013

Purpose: The purpose of this study was to evaluate a self-administered risk-assessment scoring system for identifying Omani adults with type 2 diabetes mellitus (T2DM). Methods: An exploratory cross-sectional design was used. Simple random sampling was used to select 93 adults in Muscat. Ethical approval was obtained from the College of Nursing Research and Ethics Committee. The Finnish Diabetes Risk Score (FINDRISC) was used to collect the data in 2009. Informed consent was obtained from the participants. Data were analysed with the Pearson chi-square test. Results: A total of 9.7% of the adults had very high FINDRISC and 17.2% had slightly elevated risk of developing T2DM within 10 years. The risk assessment (family history, waist circumference, body mass index, physical activity, dietary intake, hypertension and high blood glucose) of T2DM was significant and positively related to the prediction of T2DM among Omani adults.
Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes
Authors: Clemente Michael J. , Przychodzen Bartlomiej , Jerez Andres , Dienes Brittney E. , Afable Manuel G. , Husseinzadeh Holleh , Rajala Hanna L. M. , Wlodarski Marcin W. , Mustjoki Satu , Maciejewski Jaroslaw P. 
Published: October 2013

Key PointsT-cell repertoire deep sequencing clearly identifies the nucleotide and amino acid sequence of the immunodominant clone in T-LGL leukemia patients. Deep-sequencing results suggest that CD8+ T-LGL leukemia is characterized by specific CDR3 clonotypes that are private to the disease.
Amyloid β peptide-mediated neurotoxicity is attenuated by the proliferating microglia more potently than by the quiescent phenotype
Authors: Tsay Huey-Jen , Huang Yung-Cheng , Huang Fong-Lee , Chen Chia-Ping , Tsai Yu-Chun , Wang Ying-Hsiu , Wu Mine-Fong , Chiang Feng-Yi , Shiao Young-Ji 
Published: October 2013

Abstract

Background
The specific role of microglia on Aβ-mediated neurotoxicity is difficult to assign in vivo due to their complicated environment in the brain. Therefore, most of the current microglia-related studies employed the isolated microglia. However, the previous in vitro studies have suggested either beneficial or destructive function in microglia. Therefore, to investigate the phenotypes of the isolated microglia which exert activity of neuroprotective or destructive is required.

Results
The present study investigates the phenotypes of isolated microglia on protecting neuron against Aβ-mediated neurotoxicity. Primary microglia were isolated from the mixed glia culture, and were further cultured to distinct phenotypes, designated as proliferating amoeboid microglia (PAM) and differentiated process-bearing microglia (DPM). Their inflammatory phenotypes, response to amyloid β (Aβ), and the beneficial or destructive effects on neurons were investigated. DPM may induce both direct neurotoxicity without exogenous stimulation and indirect neurotoxicity after Aβ activation. On the other hand, PAM attenuates Aβ-mediated neurotoxicity through Aβ phagocytosis and/or Aβ degradation.

Conclusions
Our results suggest that the proliferating microglia, but not the differentiated microglia, protect neurons against Aβ-mediated neurotoxicity. This discovery may be helpful on the therapeutic investigation of Alzheimer’s disease.
Selenized milk casein in the diet of BALB/c nude mice reduces growth of intramammary MCF-7 tumors
Authors: Warrington Jenny M , Kim Julie JM , Stahel Priska , Cieslar Scott RL , Moorehead Roger A , Coomber Brenda L , Corredig Milena , Cant John P 
Published: October 2013

Abstract

Background
Dietary selenium has the potential to reduce growth of mammary tumors. Increasing the Se content of cows’ milk proteins is a potentially effective means to increase Se intake in humans. We investigate the effects of selenized milk protein on human mammary tumor progression in immunodeficient BALB/c nude mice.

Methods
Four isonitrogenous diets with selenium levels of 0.16, 0.51, 0.85 and 1.15 ppm were formulated by mixing low- and high-selenium milk casein isolates with a rodent premix. MCF-7 cells were inoculated into the mammary fat pad of female BALB/c nude mice implanted with slow-release 17 β-estradiol pellets. Mice with palpable tumors were randomly assigned to one of the four diets for 10 weeks, during which time weekly tumor caliper measurements were conducted. Individual growth curves were fit with the Gompertz equation. Apoptotic cells and Bcl-2, Bax, and Cyclin D1 protein levels in tumors were determined.

Results
There was a linear decrease in mean tumor volume at 70 days with increasing Se intake (P < 0.05), where final tumor volume decreased 35% between 0.16 and 1.15 ppm Se. There was a linear decrease in mean predicted tumor volume at 56, 63 and 70 days, and the number of tumors with a final volume above 500 mm3, with increasing Se intake (P < 0.05). This tumor volume effect was associated with a decrease in the proportion of tumors with a maximum growth rate above 0.03 day-1. The predicted maximum volume of tumors (Vmax) and the number of tumors with a large Vmax, were not affected by Se-casein. Final tumor mass, Bcl-2, Bax, and Cyclin D1 protein levels in tumors were not significantly affected by Se-casein. There was a significantly higher number of apoptotic cells in high-Se tumors as compared to low-Se tumors.

Conclusions
Taken together, these results suggest that turnover of cells in the tumor, but not its nutrient supply, were affected by dairy Se. We have shown that 1.1 ppm dietary Se from selenized casein can effectively reduce tumor progression in an MCF-7 xenograft breast cancer model. These results show promise for selenized milk protein as an effective supplement during chemotherapy.
Type I pyridoxal 5′-phosphate dependent enzymatic domains embedded within multimodular nonribosomal peptide synthetase and polyketide synthase assembly lines
Authors: Milano Teresa , Paiardini Alessandro , Grgurina Ingeborg , Pascarella Stefano 
Published: October 2013

Abstract

Background
Pyridoxal 5′-phosphate (PLP)-dependent enzymes of fold type I, the most studied structural class of the PLP-dependent enzyme superfamily, are known to exist as stand-alone homodimers or homotetramers. These enzymes have been found also embedded in multimodular and multidomain assembly lines involved in the biosynthesis of polyketides (PKS) and nonribosomal peptides (NRPS). The aim of this work is to provide a proteome-wide view of the distribution and characteristics of type I domains covalently integrated in these assemblies in prokaryotes.

Results
An ad-hoc Hidden Markov profile was calculated using a sequence alignment derived from a multiple structural superposition of distantly related PLP-enzymes of fold type I. The profile was utilized to scan the sequence databank and to collect the proteins containing at least one type I domain linked to a component of an assembly line in bacterial genomes. The domains adjacent to a carrier protein were further investigated. Phylogenetic analysis suggested the presence of four PLP-dependent families: Aminotran_3, Beta_elim_lyase and Pyridoxal_deC, occurring mainly within mixed NRPS/PKS clusters, and Aminotran_1_2 found mainly in PKS clusters. Sequence similarity to the reference PLP enzymes with solved structures ranged from 24 to 42% identity. Homology models were built for each representative type I domain and molecular docking simulations with putative substrates were carried out. Prediction of the protein-protein interaction sites evidenced that the surface regions of the type I domains embedded within multienzyme assemblies were different from those of the self-standing enzymes; these structural features appear to be required for productive interactions with the adjacent domains in a multidomain context.

Conclusions
This work provides a systematic view of the occurrence of type I domain within NRPS and PKS assembly lines and it predicts their structural characteristics using computational methods. Comparison with the corresponding stand-alone enzymes highlighted the common and different traits related to various aspects of their structure-function relationship. Therefore, the results of this work, on one hand contribute to the understanding of the functional and structural diversity of the PLP-dependent type I enzymes and, on the other, pave the way to further studies aimed at their applications in combinatorial biosynthesis.