bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring the impact of the interthalamic adhesion on human cognition: insights from healthy subjects and thalamic stroke patients
Authors: Vidal Julie P. , Rachita Kévin , Servais Anaïs , Péran Patrice , Pariente Jérémie , Bonneville Fabrice , Albucher Jean-François , Danet Lola , Barbeau Emmanuel J. 
Published: July 2024

AbstractThe interthalamic adhesion (IA) is a structure that connects the median borders of both thalami. Its anatomical variants and functions remain poorly studied. The main objective of this study was to explore the role of the IA on cognition. 42 healthy subjects and 40 patients with chronic isolated thalamic strokes underwent a neuroimaging and a neuropsychological assessment. The presence, absence, or lesion of the IA and its anatomical variants were evaluated. 76% of participants had an IA, with a higher prevalence among women (92%) than men (61%). The presence or absence of an IA did not affect the neuropsychological performance of healthy subjects nor did the type of IA variant. Across all the tests and when compared to healthy subjects using a Bayesian rmANOVA, patients exhibiting more cognitive impairments were those without an IA (n = 10, BF10 = 10,648), while those with an IA were more preserved (n = 18, BF10 = 157). More specifically, patients without an IA performed more poorly in verbal memory or the Stroop task versus healthy subjects. This was not explained by age, laterality of the infarct, volume or localization of the lesion. Patients with a lesioned IA (n = 12) presented a similar trend to patients without an IA, which could however be explained by a greater volume of lesions. The IA does not appear to play a major role in cognition in healthy subjects, but could play a compensatory role in patients with thalamic lesions.
Development and validation of a simulation-based assessment of operative competence for higher specialist trainees in general surgery
Authors: Toale Conor , Morris Marie , Roche Adam , Voborsky Miroslav , Traynor Oscar , Kavanagh Dara 
Published: July 2024

Abstract
Background
Simulation is increasingly being explored as an assessment modality. This study sought to develop and collate validity evidence for a novel simulation-based assessment of operative competence. We describe the approach to assessment design, development, pilot testing, and validity investigation.

Methods
Eight procedural stations were generated using both virtual reality and bio-hybrid models. Content was identified from a previously conducted Delphi consensus study of trainers. Trainee performance was scored using an equally weighted Objective Structured Assessment of Technical Skills (OSATS) tool and a modified Procedure-Based Assessment (PBA) tool. Validity evidence was analyzed in accordance with Messick’s validity framework. Both ‘junior’ (ST2–ST4) and ‘senior’ trainees (ST 5–ST8) were included to allow for comparative analysis.

Results
Thirteen trainees were assessed by ten assessors across eight stations. Inter-station reliability was high (α = 0.81), and inter-rater reliability was acceptable (inter-class correlation coefficient 0.77). A significant difference in mean station score was observed between junior and senior trainees (44.82 vs 58.18, p = .004), while overall mean scores were moderately correlated with increasing training year (rs = .74, p = .004, Kendall’s tau-b .57, p = 0.009). A pass-fail score generated using borderline regression methodology resulted in all ‘senior’ trainees passing and 4/6 of junior trainees failing the assessment.

Conclusion
This study reports validity evidence for a novel simulation-based assessment, designed to assess the operative competence of higher specialist trainees in general surgery.

Graphical abstract
Data sovereignty requirements for patient-oriented AI-driven clinical research in Germany
Authors: Radic Marija , Busch-Casler Julia , Vosen Agnes , Herrmann Philipp , Appenzeller Arno , Mucha Henrik , Philipp Patrick , Frank Kevin , Dauth Stephanie , Köhm Michaela , Orak Berna , Spiecker genannt Döhmann Indra , Böhm Peter 
Published: July 2024

Abstract
Background
The rapidly growing quantity of health data presents researchers with ample opportunity for innovation. At the same time, exploitation of the value of Big Data poses various ethical challenges that must be addressed in order to fulfil the requirements of responsible research and innovation (Gerke et al. 2020; Howe III and Elenberg 2020). Data sovereignty and its principles of self-determination and informed consent are central goals in this endeavor. However, their consistent implementation has enormous consequences for the collection and processing of data in practice, especially given the complexity and growth of data in healthcare, which implies that artificial intelligence (AI) will increasingly be applied in the field due to its potential to unlock relevant, but previously hidden, information from the growing number of data (Jiang et al. 2017). Consequently, there is a need for ethically sound guidelines to help determine how data sovereignty and informed consent can be implemented in clinical research.

Methods
Using the method of a narrative literature review combined with a design thinking approach, this paper aims to contribute to the literature by answering the following research question: What are the practical requirements for the thorough implementation of data sovereignty and informed consent in healthcare?

Results
We show that privacy-preserving technologies, human-centered usability and interaction design, explainable and trustworthy AI, user acceptance and trust, patient involvement, and effective legislation are key requirements for data sovereignty and self-determination in clinical research. We outline the implications for the development of IT solutions in the German healthcare system.
Timely integration of palliative care. the reality check. a retrospective analysis
Authors: Adamidis F. , Baumgartner N. S. , Kitta A. , Kum L. , Ecker F , Bär J , Marosi C. , Kreye G. , Fischer C. , Zeilinger E. L. , Paschen C. , Wenzel C. , Masel E. K. 
Published: July 2024

Abstract
Purpose
A large volume of literature suggests that timely integration of palliative care (PC) enhances the well-being, quality of life and satisfaction of patients and their families. It may also positively impact clinical outcomes and healthcare costs throughout the disease trajectory. Therefore, reviewing clinical practice to reflect real-life situations regarding timely PC integration is essential.

Methods
This study, conducted at the Vienna General Hospital between March 2016 and August 2022, retrospectively examined PC consultation (PCC) requests. It aimed to assess the timeliness of PC integration by analysing the duration between diagnosis and the first PCC request, as well as the interval between the first PCC request and death.

Results
This study included 895 PCCs. The median time from diagnosis to the first PCC was 16.6 (interquartile range (IQR): 3.9–48.4) months, while the median time from the first PCC to death was 17.2 (IQR: 6.1–50.7) days. The median time from diagnosis to first PCC was 10.4 months in females (confidence interval (CI): 6.0–14.8) compared to 10.6 months in males (CI: 8.1–13.1; p = 0.675). There were no gender disparities in the time from first PCC to death, with a median of 23.3 days (CI: 15.6–31.0) for females and 22.3 days (CI: 16.2–28.4) for males (p  = 0.93). Fifty percent of patients died between 5 and 47 days after the first PCC.

Conclusion
These findings highlight the discrepancy between the clinical perception of PC as end-of-life care and the existing literature, thereby emphasising the importance of timely PC integration.
Comparing the risk of severe oral mucositis associated with methotrexate as graft-versus host-disease prophylaxis to other immunosuppressive prophylactic agents in hematopoietic cell transplantation: a systematic review and meta-analysis
Authors: Al-Jamaei Aisha A. H. , Epstein Joel B. , de Visscher Jan G. A. M. , Spielberger Ricardo T. , Nakamura Ryotaro , Raber-Durlacher Judith E. 
Published: July 2024

Abstract
Purpose
This study examines the risk of severe oral mucositis (SOM) in graft-versus-host disease prophylaxis (GVHD) compared to other agents in hematopoietic cell transplantation patients.

Methods
A comprehensive search of four databases, including PubMed, Embassy, Web of Science, and Scopus, was conducted to identify studies reporting frequency and severity of oral mucositis in association with GVHD prophylactic regimens. RevMan 5.4 was used to perform the meta-analysis. Risk of bias assessment was carried out using the Rob-2 tool for randomized clinical trials (RCTs) and ROBINS-I tool for observational studies.

Results
Twenty-five papers, including 11 RCTs and 14 observational studies, met the inclusion criteria. The pooled results from eight RCTs showed a higher risk of SOM in patients receiving MTX or MTX-inclusive GVHD prophylaxis versus non-MTX alternatives (RR = 1.50, 95% CI [1.20, 1.87], I2 = 36%, P = 0.0003). Mycophenolate mofetil (MMF) and post-transplant cyclophosphamide (Pt-Cy) consistently showed lower risk of mucositis than MTX. Folinic acid (FA) rescue and mini-dosing of MTX were associated with reduced oral mucositis severity.

Conclusion
Patients receiving MTX have a higher SOM risk compared to other approaches to prevent GVHD, which should be considered in patient care. When appropriate, MMF, FA, and a mini-dose of MTX may be an alternative that is associated with less SOM. This work also underlines the scarcity of RCTs on MTX interventions to provide the best evidence-based recommendations.
On the credibility of threats to avoid the deployment of solar geoengineering
Authors: Finus Michael , Furini Francesco 
Published: July 2024

AbstractWe analyze how geoengineering in the form of solar radiation management (SRM), associated with the potential of high collateral damages, affects the governance architecture of climate agreements. We investigate under which conditions signatories to a climate agreement can avoid the deployment of SRM and implement a climate agreement on mitigation. We show that a climate agreement with all countries can be stable with the threat to deploy SRM in case a country free-rides. The threat is deterrent if collateral damages are perceived to be sufficiently high (lower threshold), but only credible if those damages are not too high (upper threshold). SRM deployment is the only threat available to signatories if they choose mitigation levels simultaneously with non-signatories (Nash–Cournot scenario). However, if signatories choose mitigation levels before non-signatories (Stackelberg scenario), an additional punishment option arises. Then if collateral damages are sufficiently large, signatories can reduce their mitigation levels and impose a heavier burden on non-signatories that would find it profitable to avoid the deployment of SRM. We show that our results are robust in two analytical frameworks frequently employed in the game-theoretic analysis of international environmental agreements.
Phosphorus and bioenergy recovery from anaerobic co-digestion of food waste and corn residues with digested sludge: effect of HRT and pre-treatment methods
Authors: Khaita Chutarat , Chinwetkitvanich Sopa , Polprasert Supawadee , Polprasert Chongchin , Patthanaissaranukool Withida 
Published: July 2024

AbstractOrganic wastes from the human ecosystem including food waste (FW), agricultural waste and digested sludge (DS) from wastewater treatment can be utilized as valuable materials in anaerobic co-digestion (AcoD) for the dual purpose of bioenergy production and phosphorus (P) recovery through a chemical precipitation process. In this study, AcoD using FW and corn residues (CS) with DS for simultaneous sustainable phosphate release and biogas production were investigated. Different hydraulic retention times (HRT) of 10, 20, and 30 days were investigated, and FW was grinded, while CS pre-treatment methods including physical (FWCS), chemical (FWCS-Chem), and thermal (FWCS-Temp) were considered. The substrates of FW and CS compositions were conducted with a total organic loading of 6 g volatile solids (VS)/L/d (5 FW/1 CS) with a carbon-to-nitrogen ratio (C/N) of 24. The results indicate that FWCS-Chem showed the highest cumulative biogas production simultaneously with P release at HRT 20 days with 7279 L/m3 and 29.67%, respectively. Moreover, the effluent from all digesters exhibited a Mg/P ratio above 1, suitable for struvite precipitation without an external Mg source. Accordingly, FW, FWCS, and FWCS-Chem achieved P recovery rates of 63.64%, 69.75%, and 70.19% at 20-day HRT, with corresponding P contents in solids of 9.45, 9.43, and 8.29%, respectively. These values are comparable to commercial phosphate fertilizer containing 8.80% P. Moreover, incinerating the precipitating solids offers high-quality P concentrations in solids of up to 15.52, 16.32, and 16.31%, respectively. Hence, 20-day HRT was found to be the optimal condition for FW, CS, and DS for anaerobic co-digestion, resulting in the highest biogas production, P release, and maximum financial return for P recovery.
Graphical abstract
Phosphorus and bioenergy recovery from anaerobic co-digestion of food waste and corn residues with digested sludge.
On the geometry and refined rate of primal–dual hybrid gradient for linear programming
Authors: Lu Haihao , Yang Jinwen 
Published: July 2024

AbstractWe study the convergence behaviors of primal–dual hybrid gradient (PDHG) for solving linear programming (LP). PDHG is the base algorithm of a new general-purpose first-order method LP solver, PDLP, which aims to scale up LP by taking advantage of modern computing architectures. Despite its numerical success, the theoretical understanding of PDHG for LP is still very limited; the previous complexity result relies on the global Hoffman constant of the KKT system, which is known to be very loose and uninformative. In this work, we aim to develop a fundamental understanding of the convergence behaviors of PDHG for LP and to develop a refined complexity rate that does not rely on the global Hoffman constant. We show that there are two major stages of PDHG for LP: in Stage I, PDHG identifies active variables and the length of the first stage is driven by a certain quantity which measures how close the non-degeneracy part of the LP instance is to degeneracy; in Stage II, PDHG effectively solves a homogeneous linear inequality system, and the complexity of the second stage is driven by a well-behaved local sharpness constant of the system. This finding is closely related to the concept of partial smoothness in non-smooth optimization, and it is the first complexity result of finite time identification without the non-degeneracy assumption. An interesting implication of our results is that degeneracy itself does not slow down the convergence of PDHG for LP, but near-degeneracy does.
Alternative therapies recently applied in controlling farmed fish diseases: mechanisms, challenges, and prospects
Authors: Elgendy Mamdouh Y. , Ali Shimaa E. , Dayem Ahmed Abdal , Khalil Riad H. , Moustafa Moustafa M. , Abdelsalam Mohamed 
Published: July 2024

AbstractThe aquaculture industry is suffering from significant financial setbacks due to an increasing frequency of disease outbreaks, posing a threat to the sector’s sustainability. Various bacterial, viral, parasitic, and fungal pathogens have led to massive mortalities in farmed fish worldwide. Throughout the years, the management of fish diseases has predominantly centered around the utilization of conventional antibiotics and chemicals. Nevertheless, their indiscriminate use has given rise to serious implications, including an increase in resistant pathogens, disruptions in the metabolic processes of fish, degradation of the aquatic environment, the presence of drug residues in aquatic products, and a potential threat to human health. Various effective bio-based and immunoprophylaxis alternative therapies have been developed to overcome these impediments. Recent alternative therapeutic approaches to fish diseases encompass a range of strategies, including phytotherapeutics, nanotherapeutics, probiotics, prebiotics, synbiotics, phage therapy, vaccination, quorum quenching, antimicrobial peptides, biosurfactants, bacteriocins, stem cells, and diagnostic-based therapy. Advancements in biotechnology have significantly enhanced the efficacy of these therapies. However, additional research is essential to refine the utilization of these therapeutic approaches. Critical concerns, such as efficacy, cost, risks, availability, and adverse effects on fish and the ecosystem, need to be addressed to establish guidelines for their sustainable application in aquaculture. This review will increase aquaculturists’ awareness of recent therapies used in fish farming, their mechanisms, challenges, and impacts while promoting the sustainability of commercial aquaculture.
Interest in and Willingness to Use PrEP: A Cross-Sectional Study of Individuals with Problematic Substance Use Residing in a High HIV Prevalence Jurisdiction
Authors: Heads Angela M. , de Dios Constanza , An Kaixuan , Yoon Jin H. , Suchting Robert , Gilmore-Thomas Adrienne , Schmitz Joy M. 
Published: July 2024

AbstractAlthough it is an effective HIV prevention method, pre-exposure prophylaxis (PrEP) is underutilized in the Southern US. Many people who use drugs (PWUD) have increased susceptibility to HIV which could be lessened by using PrEP. Potential barriers to PrEP use include lack of awareness of PrEP, low knowledge about HIV prevention, low self-efficacy for HIV prevention, inaccurate risk perceptions, and anticipated stigma. The current study examined predisposing, enabling, and reinforcing factors that may predict interest in PrEP. The purpose of the current study was to explore factors associated with interest in and willingness to use daily oral and long acting injectable PrEP among sexually active adult PWUD. The data were collected from adult participants (n = 270) residing in Harris County, TX, who self-reported problematic substance use and who reported oral, anal, or vaginal sex in the six months prior to completing the survey. The survey was distributed and completed online via Qualtrics Panels in March of 2022 and included measures of PrEP and HIV knowledge, PrEP stigma, sexual health self-efficacy, experiences of discrimination, health literacy, and medical mistrust. The majority of participants reported circumstances or behaviors that increased their susceptibility to HIV. Findings indicated that PrEP user stereotypes and PrEP anticipated disapproval by others were associated with interest in using daily oral PrEP and willingness to use long acting injectable PrEP. These results provide insight into reasons for low PrEP uptake among PWUD who live in a high HIV prevalence jurisdiction. Implications for HIV prevention intervention are discussed.
Metal distribution in three organs and edibility assessment on Coptodon rendalli from the Umgeni River impacted by metallurgic industrial activities
Authors: Hlatshwayo Sanelisiwe Siphumelele Brightness , Bissessur Ajay , Selala Mapurunyane Callies , Takai Yuki , Lebepe Jeffrey 
Published: July 2024

AbstractFish is among the most affordable and readily available protein sources for communities residing near water bodies. However, the recent pollution status of aquatic ecosystems has rendered fish consumption risky for human health. The study evaluated metal levels in the liver, gill, and muscle tissues of Redbreast tilapia (Coptodon rendalli) from Inanda and Nagle dams in the uMgeni River system. Metals, Al, Sb, Cd, Cr, Fe, Mn, Mo, Pb, and Zn were analysed using ICP-OES. Fish size showed no significant difference between the two dams (p > 0.05) whereas a descending trend liver > gill > muscle was observed for most metal levels at both dams. Moreover, there was a clear separation for metal levels in the liver, gill, and muscle between the two dams (p < 0.001) and a similar trend was observed for organs in each dam (p < 0.001). No relationship was observed between fish length and metal levels and no definite trend was observed for inter-metal relationships. Antimony, Cr, and Pb showed THQs greater than 1 at both dams which suggests health risks for consumers. Molybdenum has also shown a concerning THQs with some individuals exhibiting values ranging from 0.5 – 0.9. These findings suggest that consuming C. rendalli from the Inanda and Nagle dams could result in adverse health effects from Sb, Cr and Pb.
Culture War Complexity: How Contaminated Words and Heterodox Positions Challenge Traditional Dichotomies
Authors: Johansen Mikkel Bækby 
Published: July 2024

AbstractThis essay addresses some of the key terminological conflicts of the ongoing culture war between “wokes” and “anti-wokes” in many Western societies. In a public debate culture where words and labels are rapidly contaminated when appropriated by the “other side,” it is increasingly difficult to make sense of the key positions and battle lines to decode who is battling whom. The “culture war matrix” serves as a heuristic tool to contain some of the central culture war positions in an otherwise fragmented space of mediated discourse. Two intersecting tensions are suggested between woke and anti-woke and between cancel culture and free speech. While this two-dimensional understanding by no means exhausts the complex positionings in the culture war landscape, it represents an alternative to the one-dimensional dichotomy-thinking, which reduces the struggle to a matter of left versus right. In conclusion, a third way of understanding contemporary culture wars is suggested by focusing on heterodox impulses and alternative sources of intellectual authority.
Automatic transcription system for parliamentary debates in the context of assembly of the republic of Portugal
Authors: Nascimento Pedro , Ferreira João C. , Batista Fernando 
Published: July 2024

AbstractThe transcription of parliamentary proceedings is essential for democratic governance. Traditional methods are manual and time-consuming. This work introduces an Automatic Transcription System for the Assembly of the Republic of Portugal (STAAR) that uses an automatic speech recognition model and speaker diarization technologies. STAAR was developed after analyzing existing technologies and the Assembly’s specific needs, leading to an effective solution that integrates with current processes. STAAR stands out for its efficiency in transcribing debates and adapting to parliamentary language nuances. It significantly exceeded expectations by presenting a low transcription error rate, ranging from 1.7 to 11.3%, depending on the context and speech style, reducing the time required to produce the official parliamentary debates journal, and improving overall transcription efficiency. Additionally, STAAR enabled the transcription of previously undocumented parliamentary committee meetings, enhancing the documentation of parliamentary activities. This achievement marks a significant step in modernizing parliamentary processes, increasing transparency and accessibility of political information, and positions the Portuguese Parliament at the forefront of technological innovation in parliamentary debates transcription.