bluuebunny/crossref_metadata_2025_split huggingface dataset:
2196 – The Association Between Body Image Issues And Women's Sexual Functioning Through The Lens Of The Objectification Theory
Authors: Dakanalis A. , Riva G. , Timko A.C. , Volpato C. , Clerici M. , Zanetti A.M. 
Published: July 2013

IntroductionPhysical appearance is a major component of human sexuality. Body image is associated with females' sexual functioning; and poor body image is strongly related to sexual functioning problems (SFP). SFP are becoming more pervasive throughout Western culture. Objectification Theory (OT) provides a framework for understanding how sociocultural pressure is translated into psychological risk factors that promote body concerns and SFP. Previous research indicated that the core constructs of OT (body monitoring, body shame and appearance anxiety) predicted higher self-consciousness, which according to a recent review of 57 empirical studies, interferes with sexual responses and experiences during sexual activity.ObjectivesThe central purpose of the current study was to build upon the extant literature by incorporating internalization of the norms for body shape and weight portrayed by the media and self-consciousness during sexual activity into the OT model. Thus, we aimed to examine a more comprehensive model of women's SFP (i.e., lacking interest in sex, inability to achieve orgasm, trouble achieving or maintaining an adequate lubrication) grounded in OT.MethodsData were analysed from 391 sexually active Italian college women (Mage = 20.9) using latent variable structural equation modeling approach. Results. Internalization of media ideals led to body surveillance, which was related to body shame and appearance anxiety. The latter were related to self-consciousness during sexual activity, which in turn strongly women's SFP.ConclusionsThe study points to the role of body-image attitudes in sexual functioning and suggests that OT provides a useful framework to identify predictors of women's SFP.
2197 – Prevalence And Comorbidity Of The Autistic Disorder In School Age Children In Crete-greece
Authors: Efthimiou A. , Skounti M. , Philalithis A. 
Published: July 2013

IntroductionPrevalence of autistic disorder (AD) has increased dramatically in the last three decades. The comorbidity of the disorder with attention deficit hyperactivity disorder (ADHD) is well established, but current diagnostic criteria do not allow a dual diagnosis. In Greece, neither the prevalence of autism nor its comorbidity has been adequately examined.ObjectivesThe aim of the present study was to explore the prevalence of AD in schoolchildren in Crete and to assess its comorbidity with ADHD.MethodsThe initial sample was consisted of 7,661 children randomly selected. The study was conducted in two stages. Screening was based on school records. Only children with diagnosis of autism from the formal child psychiatric diagnostic centers were included in the sample. For each autistic child, the Teachers Report Form and the ADHD-IV scale were applied.ResultsOut of 7,661 children, 25 (0.3%) had AD. The estimated prevalence was 0.5% for boys and 0.1% for girls (p< 0.0001). Ten children (40%) fulfilled DSM-IV diagnostic criteria for ADHD. Age and gender were found to be associated significantly with the presence of ADHD. The most prevalent co-occurrent subtype of ADHD was the combined. There was not significant evidence of an association between academic impairment of autistic children and the presence of ADHD.ConclusionsThe prevalence of AD in schoolchildren in Crete, the risk factors and its comorbidity with ADHD were comparable to those reported in other countries worldwide. Younger age and male gender seems to be associated with the presence of ADHD in autistic children.
2199 – An Evaluation Of The Enhanced Cognitive-behavioural Model And Its Constructs As Moderators Of The Core Psychopathology Of Eating Pathology-bulimic Symptomatology Relationship
Authors: Dakanalis A. , Timko A.C. , Zanetti A.M. , Riva G. , Lombardi M. , Arrivabene P. , Fornoni J. , Bertelli S. , Rinaldi L. , Fraietta S. , Clerici M. 
Published: July 2013

IntroductionThe original cognitive-behavioural model of bulimia nervosa (CBT-BN) proposes that specific dysfunctional cognitions and behavioural factors maintain BN, and has provided the basis for the widely used cognitive-behavioural therapy (CBT) of BN. However, Fairburn et al. (2003) noted that among treatment completers with BN, only 40% achieved full remission of the bulimic symptomatology. The enhanced CBT-BN model (CBT-E) proposed by the authors describes how four additional factors (i.e., clinical perfectionism, low self esteem, mood intolerance and interpersonal difficulties) interact with the core psychopathology of BN (i.e., over-evaluation of eating, weight, and shape and their control) to maintain the disorder.AimsThe goal of this study was to examine (a) the validity of the CBT-E model and (b) whether each of the four hypothesized maintenance factors intensifies the core psychopathology-bulimic symptomatology relationship in a clinical sample.MethodsData were analysed from 362 adults seeking treatment for BN (n = 167) or atypical BN (n =195) at four Italian specialized care centres, using latent variable structural equation modeling approach.ResultsBoth the measurement and the structural model were good fits for the data. All four hypothesized factors exacerbated the core psychopathology-bulimic symptomatology relationship. Core psychopathology explained approximately 47.7% of the variance of bulimic symptomatology. The inclusion of the direct effects and interaction terms increased the explained variance of bulimic symptomatology to 64%.ConclusionsOverall, results supported the validity of the CBT-E model and highlighted the importance of assessment and treatment of the four maintenance processes included in the CBT-E model.
2205 – Working Memory Dependent Prefrontal-parietal Connectivity And Model-based Diagnostic Classification In Schizophrenia
Authors: Deserno L. , Brodersen K. , Lin Z. , Penny W.D. , Heinz A. , Stephan K.E. , Schlagenhauf F. 
Published: July 2013

Impaired working memory (WM) is among the best-established findings in schizophrenia. Nevertheless, functional neuroimaging studies on WM yielded inconsistent results. Disrupted functional integration in the WM network may explain neural inefficiency more precisely. This so-called ‘dysconnectivity’-hypothesis of schizophrenia focuses on abnormal synaptic plasticity.In a step towards pathophysiologically informed diagnostic classification schemes, the recent introduction of “generative embedding” procedures to neuroimaging offers the combination of neurobiologically interpretable generative models (e.g. DCMs) and support vector machines (SVM) for diagnostic classification.This fMRI study in 41 schizophrenia patients and 42 healthy controls presents four major results:1)Across controls and patients, prefrontal activation is modulated by WM performance resulting in an inverted U-curve.2)DCM of the prefrontal-parietal WM network demonstrated that WM-dependent prefrontal to parietal connectivity is reduced in all patients independent of WM performance.3)Classification in a supervised setting using generative embedding yielded 78% accuracy. Using model-based clustering in an unsupervised fashion performed almost equally well (71% accuracy).4)Subclustering schizophrenia patients revealed three distinct subgroups of patients. These subgroups exhibited different profiles of prefrontal-parietal connectivity and, critically, were found to differ significantly in clinical symptoms.This study reveals putative mechanisms underlying prefrontal inefficiency and cognitive deficits in schizophrenia, providing direct experimental evidence for the dysconnectivity hypothesis. A novel model-based clustering approach revealed three distinct subgroups of patients with unique connectivity profiles and significant differences in clinical ratings. This translational approach may help to identify specific factors underlying the variability of treatment responses and to develop subgroup-specific treatment approaches.
2212 – Again Starting
Authors: Gordillo Montaño M.J. , Martinez Anguita M.A. , Guillén Guillén E. , Ramirez Domínguez M.C. , Alonso Díaz R. 
Published: July 2013

In a situation of imminent discharge with a serious problem such as no adherence, vague and imprecise concept of the concept of psychosis, poor support and family support, poor social relationships and social skills, little emotional resonance and leave the residence, what do we do?In this case we opted for patient referral to a rehabilitation unit as the TC. This is where targets are raised to make an Individual treatment plan: improving disease awareness and treatment adherence, family information about the disease, extend relationships and use of leisure time, reduction of negative symptoms and residential support.The patient is 32 years old, daughter of separated parents, diagnosed schizophrenic psychosis with 7 hospital admissions in the last 9 years. The disease is associated with the consumption of toxic. There are changes in the character, family relationship problems, clinical delusional and hallucinatory behavior disorders with numerous leaks of the home and making marginal life. Prior to the TC is trying two leads to Area Rehabilitation Unit with treatment failure after cessation of medication. After two years of follow up in TC have achieved most of the objectives proposed at the beginning, normalizing, as far as possible, the life of the patient.
2218 – Brain-derived Neurotrophic Factor Gene Polymorphism (val66met) And The Response To Escitalopram In Depression
Authors: El-Hage W. 
Published: July 2013

IntroductionThe Brain-derived neurotrophic factor (BDNF) gene is a candidate gene for influencing the clinical response to treatment with antidepressants.ObjectiveThe aim of the study was to determine the effects of 3 and 6 weeks of escitalopram treatment in depressed patients subdivided according to the treatment response.MethodsWe included 188 French subjects with depression, 153 completed a 6-week treatment with escitalopram (10–20 mg/d). Clinical evaluation was performed using the Montgomery and Asberg Depression Rating Scale (MADRS) before treatment and after 3 and 6 weeks of treatment.ResultsAt 3 weeks of escitalopram treatment, the Met carriers had increased antidepressant response in comparison to Val/Val homozygotes. No significant clinical difference between genotype groups remained at 6 weeks of escitalopram treatment.ConclusionsOur findings further support that the Brain-Derived Neurotrophic Factor gene polymorphism (Val66Met) may play a role in antidepressant treatment response phenotypes in mood depressive episode.
2222 – Comprehensive Therapeuric Rehabilitation
Authors: Guillén E. , Ramírez Domínguez M.C. , Alonso Díaz R. , Gordillo Montaño M.J. , Martinez Anguita M.A. 
Published: July 2013

Addressing the psychosocial rehabilitation of mental health patients, can be approached in various ways. In this case illustrates how a multidisciplinary approach so early impact on rehabilitation os psychiatric illness.Patient is a woman of 45 years, starting in mental health in 1989 and with five entries in the inpatient psychiatric unit between 2006–2011, with a diagnosis of bipolar disorder. During this period has come to irregularly shaped mental health unit, with poor adherence therapeutics and instability in their symtoms, without being able to normalize their mood. Has presented several manic episodes with psychotic symptoms and depressive episodes.Treatment begins with a comprehensive approach: psychiatry, psychology, social work, and assistant nursing.Treatment objectives were: raise awareness of disease, adherence and development and expansion of social skills in order to reduce the number of admissions and achieve clinical stabilization.Included in the treatment psychoeducational group therapy, activities and social skills workshops and home visits. Therefore, we emphasize the importance of integrative treatment in the rehabilitation of this patient and the approach of this type of intervention to detect these cases.
2230 – Preliminary Validation Study Of Portuguese Version Of Cancer Coping Questionnaire
Authors: Torres A. , Pereira A. , Monteiro S. 
Published: July 2013

IntroductionThere is some evidence that cognitive behavioral therapy (CBT) in serious illness does work through its impact on coping. Cancer Coping Questionnaire (CCQ) was originally developed to assess coping strategies taught in CBT.ObjectivesIn this work the preliminary study of the psychometric characteristics of CCQ in a sample of breast cancer Portuguese women is described.AimsWe purpose to evaluate psychometric characteristics of CCQ in a Portuguese sample, namely: internal consistency, test-retest reliability and concurrent validity.MethodsThe convenience sample included 189 breast cancer patients, who fulfill CCQ and the following measures: Courtauld Emotional Control Scale (CEC); Hospital Anxiety and Depression Scale (HADS) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and the Questionnaire Breast Cancer Module (EORTC QLQC30 and BR-23). CCQ was used in two moments of assessment, the second moment after 2 months of the first.ResultsIt was obtained a Cronbach alpha of .80. The test-retest reliability show significant statistical positive correlations (rS = .59, p = .000 for individual sub-scale and rS = 65, p = .000 for interpersonal sub-scale). Significant statistical correlations between CCQ and the other measures used were also obtained.ConclusionsThe validation of the Portuguese CCQ has good psychometric proprieties of internal consistency and test-retest reliability with Portuguese breast cancer women. This instrument also demonstrated to be correlated with other assessment tools used with this population. We conclude that CCQ is a useful and a valid scale for assess the evolution of coping strategies with cancer. Future studies should include other populations.
2243 – Externalizing Problems In Young Foster Children: Prevalence Rates, Predictors And Service Use
Authors: Vanschoonlandt F. , Vanderfaeillie J. , Van Holen F. , De Maeyer S. , Robberechts M. 
Published: July 2013

ObjectiveExamining the prevalence of externalizing problems, its predictors and the mental health service use for these problems by foster children and foster parents in a representative group of foster children aged 3 to 12 in Flanders.MethodSurvey data were collected on 212 foster children, who had been in the foster family for approximately four months. Foster parents filled out a Child Behavior Checklist to measure foster children’s externalizing problems. Foster care workers reported on several potential risk variables for externalizing problems and on foster children's and foster parent's mental health service use. Predictors of externalizing problems were identified from a large number of variables using the method of purposeful selection of variables in logistic regression.Results40.6% of the foster children had externalizing problems. Foster children who were placed because of behavioral problems and whose parents received home based family support prior to the out-of-home placement had more externalizing problems. Only 20.9% of the foster children with externalizing problems and only 13.9% of their foster parents received professional help.ConclusionsThis study showed that externalizing problems are prevalent in this young foster care population, that it is hard to predict which foster children had externalizing problems, and that foster children and their foster parents rarely receive services for these problems. These findings call for a standard protocol of assessment of foster children’s externalizing problems. Moreover, from a preventive viewpoint, guidelines are needed to systematically link young foster children with externalizing problems and their foster parents to appropriate services.
2247 – Manic Episode In An Elderly Patient Secondary To The Application Of Corticosteroid Eye Drops: a Case Report
Authors: Mok V.W.L. , Malladi S.S. 
Published: July 2013

IntroductionAn eighty-one-year-old lady presented with mood changes within days of the commencement of prednisolone eye drops, which was prescribed following a cataract operation. She had a history of chronic schizophrenia, with one previous episode of hypomania in the early1990s. She was admitted to our institution on this occasion, with symptoms including elated mood, disinhibition, insomnia, pressured speech, flight of ideas and grandiose ideation. This was a distinctly different presentation from her previous relapses and the duration of this episode was prolonged. Her symptoms persisted despite an aggressive titration of psychotropic medications. After a review of her medication, the possible causal relationship between the prednisolone eye drops and manic episode was made. As the steroid eye drops were necessary following her eye operation, we allowed the completion of its course. Within days of its discontinuation, we saw a dramatIc improvement in her mental state and she was discharged. She currently remains in remission two months from the cessation of prednisolone.DiscussionThe postulation that the prednisolone eye drops triggered this manic episode can be substantiated by the clear observation that her symptoms completely resolved after the steroid course was completed. This appeared to be the one single factor which coincided with the emergence, maintenance and termination of her symptoms. Steroid-induced psychiatric symptoms are a well documented phenomenon, but are typically seen with higher doses and systemic administration of corticosteroids. This case report is of a rare presentation, and to our knowledge there are no similar cases described.
2249 – Efficacy And Safety Of 3 Agomelatine Dose Regimens (10, 25, 25-50 Mg) Versus Placebo In Out-patients Suffering From Moderate To Severe Major Depressive Disorder
Authors: Kennedy S.H. , Avedisova A. 
Published: July 2013

The present analysis assesses the 6-week antidepressant efficacy and safety of 3 agomelatine dose regimens of (10, 25, 25-50 mg) versus placebo in out-patients suffering from moderate to severe Major Depressive Disorder (MDD). In this phase III, multicentre, international, randomised, double-blind, placebo-controlled trial, 549 patients were randomized in four parallel groups: agomelatine 10 mg (n=133), agomelatine 25 mg (n=138), agomelatine 25 mg -50 mg (n=137) or placebo (n=141). In the 25-50 mg group, a dose up-titration in blinded conditions to 50 mg at week 2 was done if insufficient improvement.In the FAS (N=547), at last post-baseline assessment, there were significant and incremental differences (E(SE)) on mean HAM-D total score in favor of each agomelatine dose vs placebo: 10 mg - 2.46(0.76) (p=0.001); 25 mg - 4.71 (0.75) (p< 0.0001); 25-50 mg - 4.92 (0.76) (p< 0.0001).The response rate (decrease in HAM-D total score = 50% from baseline) was higher on each agomelatine group: 40.9% on 10 mg, 50.7% on 25 mg, 52.2% on 25-50 mg than on placebo (24.8%), p=0.005, p< 0.0001 and p< 0.0001 respectively. There were less study discontinuation on agomelatine 10 mg, 25 mg and 25-50 mg than on placebo (7.5%, 5.8%, 8.0% and 10.6% respectively) and few discontinuations for adverse events (0.8%, 0.7% and 0.7% respectively) vs none on placebo. The most frequent emergent adverse events on agomelatine (in at least 5% of patients in any agomelatine groups) were headache and nausea.These results demonstrate antidepressant efficacy at 3 dose regimens of agomelatine (10, 25, 25-50 mg) in MDD patients.
2251 – Cortical And Subcortical Gene-expression Imaging By Different n-methyl-daspartate Receptor (nmda-r) Antagonists At Glutammatergic Synapses: Implications For Dopamine-glutamate Interplay In Psychoses
Authors: Avvisati L. , Rossi R. , Latte G. , Buonaguro E.F. , Eramo A. , Marmo F. , Tomasetti C. , Sarappa C. , Iasevoli F. , de Bartolomeis A. 
Published: July 2013

IntroductionAccording to the NMDA-R hypofunction hypothesis of psychosis, the administration of certain antagonists at NMDA-R, such as ketamine, may exacerbate psychotic symptoms in humans and provide a preclinical model of psychosis. Both ketamine and antipsychotic drugs induce molecular changes in genes of the post-synaptic density (PSD), involved in glutamate signaling and dopamine-glutamate interplay.Memantine, an antagonist/partial agonist at NMDA-Rs with procognitive properties, has been proposed as an adjunctive treatment for schizophrenia.AimsWe tested the hypothesis that memantine and propsychotic NMDA-Rs antagonists (ketamine and MK-801) may elicit divergent molecular changes at glutamatergic synapses.MethodsSprague-Dawley rats were treated by:1)vehicle;2)MK-801 0.8 mg/kg;3)memantine 5 mg/kg;4)ketamine 25 mg/kg;5)ketamine 50 mg/kg.We compared, by in situ hybridization histochemistry, the expression of PSD genes in cortical and striatal brain regions.ResultsHomer1a expression was significantly induced by ketamine 25 mg/kg and reduced by MK-801 in striatum and cortex. Arc expression was significantly induced by ketamine and memantine in the cortex and by MK-801 in nucleus accumbens. Homer1b/c expression was significantly decreased by ketamine compared to vehicle in motor cortex and dorsolateral striatum. PSD-95 expression was significantly decreased by MK-801 compared to vehicle in all striatal regions and by ketamine in dorsomedial striatum.ConclusionsThese results demonstrate that NMDA-Rs antagonists with different pharmacological properties trigger different molecular changes at glutamatergic synapses. These results are consistent with the different clinical profiles of these compounds and with the observation that NMDA-R blockade is not necessarily associated to psychosis exacerbation.
2253 – Long-term Consequences Of Childhood Abuse: Effects On Mental Health
Authors: Al-Modallal H. 
Published: July 2013

IntroductionChildhood abuse is inherited in families and mainly associated with poor physical and mental health. Its association with mental health problems in adulthood is not well-studied in Jordanian women.AimThis study aimed at examining the relationship between history of childhood abuse and experiences of mental health problems in Jordanian women.ObjectivesTo assess the prevalence of childhood abuse in Jordanian women and to examine differences in mental health problems based on type of childhood abuse.MethodsData about childhood abuse and mental health problems were assessed in 409 women visiting healthcare centers. Statistical analysis included descriptive statistics for prevalence rates and one-way between-groups multivariate analysis of variance (MANOVA) for relationship between mental health and abuse experiences.ResultsEmotional abuse and physical abuse were the most frequently reported during childhood (47.1% and 46.5%, respectively). Statistically significant differences in mental health between women who experienced emotional abuse and childhood neglect and their counterparts were found (Wilks' Lambda for emotional abuse = 0.914, p < .0001; Wilks' Lambda for childhood neglect = 0.83, p < .0001). Mental health problems did not differ significantly between physically and sexually abused women with their counterparts.ConclusionsMental health consequences of childhood abuse last to adulthood. Emotional abuse and neglect can be more harmful and more damaging to women's mental well-being than physical and sexual abuse. Mental health consequences of childhood abuse may alter women's commitments and obligations to others. Therefore, professional health efforts focusing on mental health should be established in healthcare centers.