bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphatase and tensin homolog‐induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy
Authors: Tang Ying , Liu Jiankang , Long Jiangang 
Published: October 2014

AbstractDiabetes is an independent risk factor for cardiovascular morbidity and mortality. Diabetes‐associated cardiac pathophysiology is recognized to be due to reasons including metabolic consequences on the myocardium. The heart is a highly energy‐demanding tissue, with mitochondria supplying over 90% of adenosine triphosphate. The involvement of mitochondrial dysfunction in diabetes‐related cardiac pathogenesis has been studied. Phosphatase and tensin homolog‐induced putative kinase 1 (PINK1) and Parkin, initially identified to be associated with the pathogenesis of a familiar form of Parkinson's disease, have recently been recognized to play a critical role in mediating cardiomyocytes’ adaption to stresses. Extensive studies have suggested PINK1 and Parkin as key regulators of mitophagy. In the present review article, we will first summarize the new findings on PINK1/Parkin acting in cardioprotection, and then discuss the potential role of PINK1/Parkin in diabetic heart by mediating mitophagy.
Natural Occurrence of Wild tomato mosaic virus in Wild Eggplant in China
Authors: Zhang Shaoyan , Yu Naitong , Wang Xiang , Liang Jie , Xie Huimin , Wang Jianhua , Zhang Yuliang , Liu Zhixin 
Published: October 2014

AbstractIn winter 2013, typical symptoms of green crinkling and mosaic were observed on wild eggplant leaves in field in Hainan, China. The causal pathogen was identified to be a Wild tomato mosaic virus (WTMV) based upon reverse transcription‐touchdown PCR with degenerate primers. A specific product of 1700 bp containing the partial sequence of the NIb (~950 bp) and CP (~750 bp) coding regions of WTMV was amplified, and the predicted polypeptide consisted of 572 amino acids (Mr 65.52 kDa). This isolate was subsequently named WTMV‐Hainan (GenBank accession KF918754) isolate, and it shared sequence identities of 91% and 95% with WTMV‐Laichau isolate at the nucleotide and the amino acid levels, respectively. Phylogenetic analysis of the CP gene sequences provided further evidence that all WTMV isolates formed a high‐confidence subclade and WTMV‐Hainan most closely related to WTMV‐KAN, WTMV‐Laichau and WTMV‐GD1. To our knowledge, this is the first report of the natural infection of WTMV on wild eggplant in China.
Texture Properties of Miniature Chihuahua‐Type Cheese Manufactured with Different Strains of Lactococcus Lactis Isolated from Plants and Raw Milk Cheese
Authors: Nájera‐Domínguez Carolina , Gutiérrez‐Méndez Nestor , Aguirre‐Gardea Karen , Peralta‐Bolivar Ana , Chavez‐Garay Dely R. , Leal‐Ramos Martha Y. 
Published: October 2014

AbstractThere is a growing interest to explore new wild strains of Lactococcus lactis because of their ability to generate certain flavor compounds due to differences in their metabolic activities. However, it is believed that plant‐derived strains of lactococci have a limited ability to ferment lactose and hydrolyze the milk proteins. It is therefore hypothesized that cheese manufactured with plant‐derived strains of L. lactis might develop a harder texture than cheese manufactured with commercial strains or strains isolated from raw milk products. The aim of this work was to describe the texture properties of cheese manufactured with different strains of L. lactis isolated from raw milk cheese and vegetables. The miniature cheese manufactured with diverse strains of L. lactis showed a wide range of textures. The source of isolation of L. lactis did not predispose the proteolytic activities of the strains or the cheese texture properties. The plant‐derived strains did not produce the hardest cheese.Practical ApplicationsNowadays, cheese makers from Chihuahua are encouraged to produce cheese using pasteurized milk. However, these pasteurized milk cheese have shown differences in flavor and texture in comparison with artisanal raw milk cheese. One of the most promising options to emulate the flavor and texture of artisanal cheese is the utilization of native lactic acid bacteria isolated from raw milk cheese and vegetables. Some of these bacteria are able to produce flavor similar to that of artisanal cheese but their effect on cheese texture is still unclear. From the results of this work, it was observed that some of these wild strains of lactic acid bacteria are able to produce cheese with texture similar to that observed in artisanal Chihuahua cheese. Therefore, these bacteria could be used as a starter culture in the manufacture of Chihuahua cheese with pasteurized milk.
Synergistic Effects of Calcium Hydroxide and Konjac Glucomannan (KGM) on the Thermomechanical Properties of Buckwheat Flour and the Quality of Buckwheat Noodles
Authors: Han Lihong , Cheng Yongqiang , Zhang Qiang , Ma Haijun , Tatsumi Eizo , Li Lite 
Published: October 2014

AbstractBased on the results of previous studies, 0.4% calcium hydroxide and varying proportions of konjac glucomannan (KGM) were used to optimize the rheological behavior of buckwheat flour and the quality of buckwheat noodles in this study. The results revealed that the thermomechanical properties of buckwheat flour were markedly improved by KGM and calcium hydroxide, as shown in detail by the increased stability and decreased degree of protein weakening in the buckwheat dough. Adding 1.5% KGM and 0.4% calcium hydroxide significantly improved the tensile strength and firmness of the cooked noodles. Microstructural analysis confirmed that 0.4% calcium hydroxide notably affected the development of the starch–gel and KGM–gel network in the cooked noodle samples. These results indicate that a combination of calcium hydroxide and KGM can be used to improve the properties of buckwheat flour for buckwheat‐based food production and to improve the quality of buckwheat end products.Practical ApplicationsBuckwheat has been limited in noodle preparations by manufacturing difficulties and poor cooking and sensory qualities. These results indicate that a combination of calcium hydroxide and konjac glucomannan can be used to improve the properties of buckwheat flour for buckwheat‐based food production and to improve the quality of buckwheat end products.
Size and shape of the sella turcica in subjects withDown syndrome
Authors: Korayem M. , AlKofide E. 
Published: October 2014

Structured AbstractObjectivesTo study size and shape of the sella turcica in individuals with Down syndrome (DS) and compare them to matched controls without the syndrome.Setting and sample populationThe Department of Pediatric Dentistry and Orthodontics. Lateral cephalograms of sixtyDSindividuals and sixty controls were obtained with an age range of 12–22 years.Materials and methodsThe length, depth, and diameter of the sella turcica were calculated. In addition, the shape of the sella turcica was described as either normal or with aberrations such as; oblique anterior wall, sella turcica bridging, extremely low sella turcica, irregularity in the posterior part of the dorsum sella, and pyramidal shape of the dorsum sella.ResultsAn increase in the diameter and depth of sella turcica was found more frequently inDSgroup as compared to controls (P < 0.05 andP < 0.0001, respectively). When the shape of the sella turcica was examined, a normal sella turcica shape was found less often inDS(P < 0.05). The most common abnormality detected was an oblique anterior wall (P < 0.05). A sella turcica bridge, irregularity in the posterior wall, and a pyramidal shape of sella turcica were present simultaneously in some individuals withDS(P < 0.01).ConclusionThe sella turcica inDSdiffers in size and morphology when compared to individuals without the syndrome. The diameter and depth of the sella turcica inDSare larger than controls, with a tendency toward more abnormalities in the shape of sella turcica.
Observational assessment of communication disorders in vascular dementia patients with right hemisphere damage
Authors: Kawada Miyuki , Tanaka Naofumi , Yamaguchi Satoshi , Meguro Kenichi 
Published: October 2014

AbstractAimAfter stroke, communication disability often occurs, with left side brain‐damaged (LBD) patients having aphasia and right side brain‐damaged (RBD) patients having deficits in conversation, despite their apparent lack of any language disability. Herein, we developed an original scale, theDailyCommunicationAssessmentScale (DCAS) and compared the scores from theRBDand left side brain‐damaged patients with their matchedMini‐MentalStateExamination (MMSE) scores.MethodsThis cross‐sectional survey involved three pairs ofMMSE‐matched patients (n= 6) with vascular dementia who met the following criteria: a history of stroke, unilateral localized basal ganglia legion (as shown by magnetic resonance imaging/computed tomography images),MMSEscores ≥9, and ability to engage in minimal conversation. Patients'MMSEscores were 11, 12, 15, 16, and 19. We interviewed patients' primary staff regarding their abilities to communicate over the previous 4 weeks in order to evaluate them using theDCAS.ResultsIn eachMMSE‐matched pair, theRBDpatient had a lower Deviation score on theDCAS, and in two pairs, the left side brain‐damaged patient had a lower score for Coarse speech.ConclusionWe believe that communication disorder in theRBDpatients may be evaluated with theDCAS. We plan to standardize theDCASand apply it for use in rehabilitation in the future.
Ipsative imputation for a 15‐item Geriatric Depression Scale in community‐dwelling elderly people
Authors: Imai Hissei , Furukawa Toshiaki A. , Kasahara Yoriko , Ishimoto Yasuko , Kimura Yumi , Fukutomi Eriko , Chen Wen‐ling , Tanaka Mire , Sakamoto Ryota , Wada Taizo , Fujisawa Michiko , Okumiya Kiyohito , Matsubayashi Kozo 
Published: October 2014

AbstractBackgroundMissing data are inevitable in almost all medical studies. Imputation methods using the probabilistic model are common, but they cannot impute individual data and require special software. In contrast, the ipsative imputation method, which substitutes the missing items by the mean of the remaining items within the individual, is easy and does not need any special software, but it can provide individual scores. The aim of the present study was to evaluate the validity of the ipsative imputation method using data involving the 15‐item Geriatric Depression Scale.MethodsParticipants were community‐dwelling elderly individuals (n = 1178). A structural equation model was constructed. The model fit indexes were calculated to assess the validity of the imputation method when it is used for individuals who were missing 20% of data or less and 40% of data or less, depending on whether we assumed that their correlation coefficients were the same as the dataset with no missing items. Finally, we compared path coefficients of the dataset imputed by ipsative imputation with those by multiple imputation.ResultsWhen compared with the assumption that the datasets differed, all of the model fit indexes were better under the assumption that the dataset without missing data is the same as that that was missing 20% of data or less. However, by the same assumption, the model fit indexes were worse in the dataset that was missing 40% of data or less. The path coefficients of the dataset imputed by ipsative imputation and by multiple imputation were compatible with each other if the proportion of missing items was 20% or less.ConclusionIpsative imputation appears to be a valid imputation method and can be used to impute data in studies using the 15‐item Geriatric Depression Scale, if the percentage of its missing items is 20% or less.
Measuring the Foreign Exchange Premium and the Premium for Non‐Tradable Outlays for 20 Countries in Africa
Authors: Kuo Chun‐Yan , Salci Sener , Jenkins Glenn P. 
Published: October 2014

AbstractIn this paper, we develop an analytical general equilibrium framework to measure the foreign exchange premium and the premium for non‐tradable outlays for a country. The framework allows us to capture in a consistent manner the impacts of the sourcing of funds and their expenditure on tradable and non‐tradable goods and services of investment projects. An application of the model is carried out for 20 countries in Africa. The results show that the foreign exchange premiums range from 2.4% to 9.0% and the premium for non‐tradable outlays from −0.7% to 2.9%. The empirical values depend on a number of factors, including the indirect taxes, production subsidies and international trade distortions of a country. These premiums should be incorporated into the economic evaluation of investment projects.
Resurrection, revision and molecular phylogenetics of ErageniaBanks with implications for Ageniellini systematics (Hymenoptera: Pompilidae)
Authors: WAICHERT CECILIA , VON DOHLEN CAROL D. , PITTS JAMES P. 
Published: October 2014

AbstractPriocnemella Banks is a small Neotropical genus within Ageniellini with remarkable morphological variation between species. Some species are small and variable in colour, whereas others are large with black integument and yellow wings. We conducted a phylogenetic analysis of Priocnemella based on the mitochondrial gene cytochrome oxidase I and the nuclear marker long‐wavelength rhodopsin. Our results indicated that Priocnemella is a paraphyletic genus. Based on molecular phylogenetic analyses, we discuss the taxonomic validity of Priocnemella, its implications and a new circumscription of genera of Ageniellini. Eragenia Banks is revalidated (stat. rev.) and applied to 16 species, eight of which are newly described: Eragenia bella Waichert & Pitts sp.n., E. carinata Waichert & Pitts sp.n., E. dentata Waichert & Pitts sp.n., E. oliva Waichert & Pitts sp.n., E. pseudomicans Waichert & Pitts sp.n., E. setosa Waichert & Pitts sp.n., E. rotunda Waichert & Pitts sp.n., E. villosa Waichert & Pitts sp.n., E. abdominalis (Smith), E. amabilis (Taschenberg), E. aureicornis (Smith), E. coerulipes (Smith), E. congrua (Fox), E. isolata (Banks), E. micans (Fabricius), and E. tabascoensis (Cameron). Priocnemella fairchildi (Banks), P. insignis (Banks), P. eurytheme Banks, P. hexagona (Fox) and P. hexagona omissa Banks maintain their generic status. Phanochilus Banks is considered a junior synonym of Priocnemella and the following species are newly placed within Priocnemella: P. fuscomarginata (Fox), P. gloriosa (Smith), P. nobilitata (Smith) and P. ornata (Banks). The following nomenclatural changes are proposed: Priocnemella rufothorax (Banks) is synonymized under Eragenia micans (Fabricius) (syn. n.); Priocnemella delila (Banks), Priocnemella bequaerti (Banks) and Priocnemella infelix (Banks) are junior synonyms of Eragenia aureicornis (Smith) (syn.n.) (comb.n). New combinations are proposed for Eragenia aureicornis (Smith) comb.n., Eragenia abdominalis (Smith) comb.n. and Eragenia coerulipes (Smith) comb.n. from Agenia; and Eragenia congrua (Fox) comb.n. from Salius. A neotype is designated for E. coerulipes and for E. tabascoensis. Divergence dates between species of Eragenia, ancestral areas and pattern of dispersal that shaped the current geographic distribution are discussed. The genus is about 9.8 Ma old, originating in Mesoamerica during the Miocene. Finally, newly described male genitalic characters are discussed and illustrated, and illustrated keys for males and females species of Eragenia are provided.This work has been registered in ZooBank, http://zoobank.org/urn:lsid:zoobank.org:pub:8308D00F‐E25E‐4019‐A94B‐DCAEDED67D4C.
Draft Genome Sequence of Virulent Strain AUSTRAL-005 of Piscirickettsia salmonis, the Etiological Agent of Piscirickettsiosis
Authors: Yañez Alejandro J. , Molina Cristian , Haro Ronie E. , Sanchez Patricio , Isla Adolfo , Mendoza Julio , Rojas-Herrera Marcelo , Trombert Annette , Silva Andrea X. , Cárcamo Juan G. , Figueroa Jaime , Polanco Victor , Manque Patricio , Maracaja-Coutinho Vinicius , Olavarría Víctor H. 
Published: October 2014

ABSTRACT

We report here the draft genome sequence of a lethal pathogen of farmed salmonids,
Piscirickettsia salmonis
strain AUSTRAL-005. This virulent strain was isolated in 2008 from
Oncorhynchus mykiss
farms, and multiple genes involved in pathogenicity, environmental adaptation, and metabolic pathways were identified.
Genome Sequence of Coxsackievirus A6, Isolated during a Hand-Foot-and-Mouth Disease Outbreak in Finland in 2008
Authors: Österback Riikka , Koskinen Satu , Merilahti Pirjo , Pursiheimo Juha-Pekka , Blomqvist Soile , Roivainen Merja , Laiho Asta , Susi Petri , Waris Matti 
Published: October 2014

ABSTRACTReports of hand-foot-and-mouth disease (HFMD) outbreaks caused by coxsackievirus A6 have increased worldwide after the report of the first outbreak in Finland in 2008. The complete genome of the first outbreak strain from a vesicle fluid specimen was determined.
Genome Sequence of an Extremely Drug-Resistant Clinical Isolate of Acinetobacter baumannii Strain AB030
Authors: Loewen Peter C. , Alsaadi Yasser , Fernando Dinesh , Kumar Ayush 
Published: October 2014

ABSTRACT

We report the 4.3-Mbp genome sequence of a blood isolate of
Acinetobacter baumannii
strain AB030.
Genome Sequence of a Tigecycline-Resistant Clinical Isolate of Acinetobacter baumannii Strain AB031 Obtained from a Bloodstream Infection
Authors: Loewen Peter C. , Alsaadi Yasser , Fernando Dinesh , Kumar Ayush 
Published: October 2014

ABSTRACT

We report here the 3.8-Mbp genome sequence of a blood isolate of
Acinetobacter baumannii
strain AB031.
Draft Genome Sequence of Amycolatopsis lurida NRRL 2430, Producer of the Glycopeptide Family Antibiotic Ristocetin
Authors: Kwun Min Jung , Hong Hee-Jeon 
Published: October 2014

ABSTRACT

We report here the first draft genome sequence for
Amycolatopsis lurida
NRRL 2430, the producer of the glycopeptide antibiotic ristocetin. The 9-Mbp genome is predicted to harbor 8,143 genes, including those belonging to the ristocetin biosynthesis cluster and 31 additional predicted secondary metabolite gene clusters.
Complete Genome Sequence of the Solvent Producer Clostridium saccharoperbutylacetonicum Strain DSM 14923
Authors: Poehlein Anja , Krabben Preben , Dürre Peter , Daniel Rolf 
Published: October 2014

ABSTRACT

Clostridium saccharoperbutylacetonicum
strain DSM 14923 is known as a butanol-producing bacterium. Various organic compounds such as glucose, fructose, sucrose, mannose, and cellobiose are fermented. The genome consists of one chromosome and one circular megaplasmid.
C. saccharoperbutylacetonicum
was used in industrial fermentation processes to produce the solvents acetone, butanol, and ethanol.
Complete Genome Sequence of Mycoplasma capricolum subsp.
capripneumoniae
Strain 9231-Abomsa
Authors: Dupuy Virginie , Thiaucourt François 
Published: October 2014

ABSTRACT

Mycoplasma capricolum
subsp.
capripneumoniae
is the etiological agent of contagious caprine pleuropneumonia. We report here the complete and annotated genome sequence of
M. capricolum
subsp.
capripneumoniae
strain 9231-Abomsa.
Genome Sequence of Legionella massiliensis, Isolated from a Cooling Tower Water Sample
Authors: Pagnier Isabelle , Croce Olivier , Robert Catherine , Raoult Didier , La Scola Bernard 
Published: October 2014

ABSTRACT

We present the draft genome sequence of
Legionella massiliensis
strain LegA
T
, recovered from a cooling tower water sample, using an amoebal coculture procedure. The strain described here is composed of 4,387,007 bp, with a G+C content of 41.19%, and its genome has 3,767 protein-coding genes and 60 predicted RNA genes.
Contributions of Nitric Oxide and Prostaglandins to the Local Increase in Muscle Blood Flow following Manual Acupuncture in Rats
Authors: Shinbara Hisashi , Okubo Masamichi , Kimura Keisaku , Mizunuma Kunio , Sumiya Eiji 
Published: October 2014

Objective To investigate the contributions of nitric oxide (NO) and prostaglandins (PGs) to the increase in local muscle blood flow (MBF) observed following manual acupuncture (MA). Methods Male Sprague-Dawley rats (n=112; 250–310 g) were injected intraperitoneally with a non-selective NO synthase inhibitor (NG-nitro-L-arginine methyl ester hydrochloride: L-NAME; 10, 50 or 500 mg/kg), a non-selective cyclo-oxygenase inhibitor (indomethacin; 10, 50 or 500 mg/kg), a combination of L-NAME and indomethacin (500 mg/kg each) or saline only under urethane anaesthesia (1.2 g/kg). We used the sparrow pecking technique for 1 min with a stainless steel acupuncture needle (0.20×30 mm) as the acupuncture stimulation method. The stimulus point was on the right tibialis anterior muscle. 51Chromium-labelled microspheres were used for MBF measurement. Results MA increased MBF in the saline-injected group (p<0.001). This increase was partially inhibited by L-NAME in a dose-dependent manner (p>0.05, p<0.05 and p<0.001 for 10, 50 and 500 mg/kg, respectively). On the other hand, indomethacin did not suppress the increase (p>0.05 each for 10, 50 and 500 mg/kg). No significant difference was observed between the inhibitory effects of combined administration of L-NAME and indomethacin and single administration of L-NAME (p>0.05). Conclusions These results suggest that NO is a major factor in the MA-induced increase in MBF, while PGs do not contribute significantly to this increase. As complete inhibition was not achieved by administration of L-NAME±indomethacin, it appears that non-NO and non-PG vasodilators are additionally involved.
Towards a new point of view on the phenotype of patients with a 17q12 microdeletion syndrome
Authors: Laffargue Fanny , Bourthoumieu Sylvie , Llanas Brigitte , Baudouin Véronique , Lahoche Annie , Morin Denis , Bessenay Lucie , De Parscau Loïc , Cloarec Sylvie , Delrue Marie-Ange , Taupiac Emmanuelle , Dizier Emilie , Laroche Cécile , Bahans Claire , Yardin Catherine , Lacombe Didier , Guigonis Vincent 
Published: October 2014

Objective17q12 microdeletion syndrome involves 15 genes, includingHNF1B, and is considered to confer a high risk of neuropsychiatric disorders. Patients withHNF1Bgene deletion diagnosed secondary to renal disorders are only very rarely reported to have neuropsychiatric disorders. Interestingly, however, when tested, patients withHNF1Bgene deletion are found to have 17q12 deletion. This brings into question the extent to which 17q12 deletion is genuinely associated with severe neuropsychological disorders and in which patients. In this study, we sought to confirm 17q12 microdeletion in kidney patients initially diagnosed withHNF1Bgene deletion and evaluate neuropsychological disorders in these patients compared with those withHNF1Bpoint mutation.Patients and designThirty-nine children withHNF1Bdisorders (26 with deletions) diagnosed secondary to renal abnormalities were included in this prospective study and tested for 17q12 microdeletion and neuropsychological disorders.ResultsThe same 17q12 microdeletion found in patients with neuropsychological disorders was identified in all of our patients withHNF1Bdeletion. Neurological examinations found no severe impairments except for one patient with autism. No significant differences were found between patients with deletions and those with point mutations as concerns learning abilities and schooling. Nevertheless, patients with deletions tended to have lower developmental quotients and more difficulties at school.ConclusionsComplete deletion of theHNF1Bgene and 17q12 microdeletion syndrome are actually the same genetic disorder. The neuropsychological phenotype of patients appears less severe when 17q12 deletion is diagnosed secondary to kidney rather than neuropsychological abnormalities. These data may influence antenatal counselling.