bluuebunny/crossref_metadata_2025_split huggingface dataset:
The inter‐disciplinary modelling of supply chains in the context of collaborative multi‐structural cyber‐physical networks
Authors: Ivanov Dmitry , Sokolov Boris 
Published: October 2012

PurposeOn modern markets, supply chains (SC) shape the competition landscape. At the same time, considerable research advancements have been recently achieved in the area of collaborative networks. Trends in information technology progress for networked systems include development of cyber‐physical networks, cloud service environments, etc. The purpose of this paper is to identify an inter‐disciplinary perspective and modelling tools for new generation SCs which will be collaborative cyber‐physical networks.Design/methodology/approachThis study addresses the above‐mentioned research goal by first, developing a methodical vision of an inter‐disciplinary modelling framework for SCM based on the existing studies on SC operations, control and systems theories; and second, by integrating elements of different structures with structures dynamics within an adaptive framework based upon the authors' own research.FindingsThe inter‐disciplinary modelling framework for multi‐structural SCs has been developed. A new inter‐disciplinary level of model‐based decision‐making support in those SCs is claimed based on the integration of previously isolated problems and modelling tools developed in such disciplines like operations research, control theory, system dynamics, and artificial intelligence.Originality/valueThe novelty of this paper is the consideration of SC modelling in the context of collaborative cyber‐physical systems. This topic is particularly relevant for researchers and practitioners who are interested in future generation SCs. Particular focus is directed towards the multi‐structural SC modelling, structure dynamics, and inter‐disciplinary problems and models in future SCs. Challenges of integrated optimization in the organizational and informational context are discussed.
Appraising interdisciplinary contributions to theory for collaborative (manufacturing) networks
Authors: Dekkers Rob , Kühnle Hermann 
Published: October 2012

PurposeProgress in theory building in the field of collaborative networks in manufacturing is preponderantly seen in contributions from disciplines outside manufacturing science. Interdisciplinary research is one way of accelerating the development of appropriate theory for this emerging domain where industrial practice has moved beyond the state of the art of scientific knowledge for establishing workable, competitive solutions. The purpose of this paper is to examine to what extent interdisciplinary research has contributed to a better understanding of collaborative (manufacturing) networks.Design/methodology/approachTo find out more about provenances of on‐going studies, to identify clusters of contributions and to provide direction for future work of researchers in this domain, publications of the past 22 years have been evaluated. To retrieve these contributions, a structured literature review has been undertaken by applying keywords to selected databases and using a strictly defined stepwise procedure. In total, 202 publications of all kinds have been evaluated.FindingsFrom the analysis of the results, it appears that most interdisciplinary contributions to collaborative (manufacturing) networks rely on one original outside discipline for either developing solutions or advancing theoretical insight. Consequently, and after further analysis, it seems that researchers in collaborative networks hardly resort to multi‐disciplinary approaches, unless “natural”; further advances might arrive from stimulating these multi‐disciplinary avenues rather than sticking to more mono‐disciplinary, and less risky, takes on both applications and theoretical insight. A more detailed investigation of the value of contributions reveals that efforts to make interdisciplinary advances are either difficult or limited. Also, the findings indicate that researchers tend to follow a more “technical” approach to decision making by actors in networks rather than searching for a shift in paradigm.Originality/valueWhile setting out these directions for future research and guiding research, this first‐of‐its‐kind review introduces the collaboration model as a systematic approach to collaborative (manufacturing) networks. This model might serve as a reference model to integrate disciplines for addressing the characteristics of Collaborative Networks. Its use in the review led to the finding that typical traits of networks, such as changeability, supplementary assets and decentralisation of decision making, are under‐researched.
Lessons learned from the lifecycle management of collaborative enterprises networks
Authors: Cheikhrouhou Naoufel , Pouly Michel , Huber Charles , Beeler Jean 
Published: October 2012

PurposeResearch on the dynamics of Collaborative Enterprises Networks (CEN) lacks consistency and industrial feedback. The purpose of this paper is to present insights and lessons learned from an industrial case study dealing with the practical experience gathered during the creation, alliance development, and business operation phases of a CEN.Design/methodology/approachThe proposed research methodology relies on qualitative approach, using unstructured interviews with the main decision makers in the network. The objective of the interviews is to highlight the most important events in the lifecycle of the network. From the important elements discussed, success and failure key factors are identified.FindingsThrough the case study, the authors identify the main success and failure key factors to consider in CENs. Furthermore, relying on the current state of the art, they highlight the main research directions, particularly with respect to the development of modelling approaches capturing the dynamics of these systems.Originality/valueThe identification of the success and failure key factors and their corresponding technologies, systems and human perspectives is aimed at providing links between theoretical models and practical implications to both academics and industrialists. The challenges and developmental areas proposed provide the basis for new models capturing the dynamics and the evolution of CENs.
Chinese online literature: creative consumers and evolving business models
Authors: Ren Xiang , Montgomery Lucy 
Published: October 2012

PurposeThe internet is transforming possibilities for creative interaction, experimentation and cultural consumption in China and raising important questions about the role that “publishers” might play in an open and networked digital world. The purpose of this paper is to consider the role that copyright is playing in the growth of a publishing industry that is being “born digital”.Design/methodology/approachThe paper approaches online literature as an example of a creative industry that is generating value for a wider creative economy through its social network market functions. It builds on the social network market definition of the creative industries proposed by Pottset al.and uses this definition to interrogate the role that copyright plays in a rapidly‐evolving creative economy.FindingsThe rapid growth of a market for crowd‐sourced content is combining with growing commercial freedom in cultural space to produce a dynamic landscape of business model experimentation. Using the social web to engage audiences, generate content, establish popularity and build reputation and then converting those assets into profit through less networked channels appears to be a driving strategy in the expansion of wider creative industries markets in China.Originality/valueAt a moment when publishing industries all over the world are struggling to come to terms with digital technology, the emergence of a rapidly‐growing area of publishing that is being born digital offers important clues about the future of publishing and what social network markets might mean for the role of copyright in a digital age.
Cultural consumption and souvenirs: an ethical framework
Authors: Brennan Linda , Savage Theresa 
Published: October 2012

PurposeThe purpose of this paper is to propose guidelines for business enterprises engaging with indigenous communities to protect their intellectual property rights, particularly indigenous art works produced for the souvenir industry.Design/methodology/approachLiterature on indigenous art and souvenirs demonstrating exploitation of indigenous communities’ intellectual property was facilitated by a lack of knowledge of how to otherwise behave. The proposed guidelines for commercial entities wishing to engage ethically with indigenous communities draws on international exemplars.FindingsA twelve‐point framework for ethical commerce in indigenous souvenirs between indigenous communities and businesses is proposed to ensure populations lacking economic and social power are not disenfranchised by limited experience in a market society.Social implicationsThe proposed guidelines contribute to achieving reconciliation between mainstream and indigenous people in various countries throughout the world.Originality/valueThis paper assists development of guidelines enabling ethical decision‐making in the souvenir industry applying a critical approach to the principles of corporate responsibility.
Metabolomics of hexachlorocyclohexane (HCH) transformation: ratio of LinA to LinB determines metabolic fate of HCH isomers
Authors: Geueke Birgit , Garg Nidhi , Ghosh Sneha , Fleischmann Thomas , Holliger Christof , Lal Rup , Kohler Hans‐Peter E. 
Published: October 2012

SummaryAlthough the production and use of technical hexachlorocyclohexane (HCH) and lindane (the purified insecticidal isomer γ‐HCH) are prohibited in most countries, residual concentrations still constitute an immense environmental burden. Many studies describe the mineralization of γ‐HCH by bacterial strains under aerobic conditions. However, the metabolic fate of the other HCH isomers is not well known. In this study, we investigated the transformation of α‐, β‐, γ‐, δ‐, ε‐HCH, and a heptachlorocyclohexane isomer in the presence of varying ratios of the two enzymes that initiate γ‐HCH degradation, a dehydrochlorinase (LinA) and a haloalkane dehalogenase (LinB). Each substrate yielded a unique metabolic profile that was strongly dependent on the enzyme ratio. Comparison of these results to those of in vivo experiments with different bacterial isolates showed that HCH transformation in the tested strains was highly optimized towards productive metabolism of γ‐HCH and that under these conditions other HCH‐isomers were metabolized to mixtures of dehydrochlorinated and hydroxylated side‐products. In view of these results, bioremediation efforts need very careful planning and toxicities of accumulating metabolites need to be evaluated.
Dryland biological soil crust cyanobacteria show unexpected decreases in abundance under long‐term elevated CO2
Authors: Steven Blaire , Gallegos‐Graves La Verne , Yeager Chris M. , Belnap Jayne , Evans R. David , Kuske Cheryl R. 
Published: October 2012

SummaryBiological soil crusts (biocrusts) cover soil surfaces in many drylands globally. The impacts of 10 years of elevated atmospheric CO2 on the cyanobacteria in biocrusts of an arid shrubland were examined at a large manipulated experiment in Nevada, USA. Cyanobacteria‐specific quantitative PCR surveys of cyanobacteria small‐subunit (SSU) rRNA genes suggested a reduction in biocrust cyanobacterial biomass in the elevated CO2 treatment relative to the ambient controls. Additionally, SSU rRNA gene libraries and shotgun metagenomes showed reduced representation of cyanobacteria in the total microbial community. Taxonomic composition of the cyanobacteria was similar under ambient and elevated CO2 conditions, indicating the decline was manifest across multiple cyanobacterial lineages. Recruitment of cyanobacteria sequences from replicate shotgun metagenomes to cyanobacterial genomes representing major biocrust orders also suggested decreased abundance of cyanobacteria sequences across the majority of genomes tested. Functional assignment of cyanobacteria‐related shotgun metagenome sequences indicated that four subsystem categories, three related to oxidative stress, were differentially abundant in relation to the elevated CO2 treatment. Taken together, these results suggest that elevated CO2 affected a generalized decrease in cyanobacteria in the biocrusts and may have favoured cyanobacteria with altered gene inventories for coping with oxidative stress.
Pyoverdine biosynthesis and secretion in Pseudomonas aeruginosa: implications for metal homeostasis
Authors: Schalk Isabelle J. , Guillon Laurent 
Published: October 2012

SummaryPyoverdines are siderophores produced by fluorescent Pseudomonads to acquire iron. At least 60 different pyoverdines produced by diverse strains have been chemically characterized. They all consist of a dihydroquinoline‐type chromophore linked to a peptide. These peptides are of various lengths and the sequences are strain specific. Pyoverdine biosynthesis in Pseudomonas aeruginosa and fluorescent Pseudomonads is a complex process involving at least 12 different proteins, starting in the cytoplasm and ending in the periplasm. The cellular localization of pyoverdine precursors was recently shown to be consistent with their biosynthetic enzymes. In the cytoplasm, pyoverdine appears to be assembled at the inner membrane and particularly at the old cell pole of the bacterium. Mature pyoverdine is uniformly distributed throughout the periplasm, like the periplasmic enzyme PvdQ. Secretion of pyoverdine involves a recently identified ATP‐dependent efflux pump, PvdRT‐OpmQ. This efflux system does not only secrete newly synthesized pyoverdine but also pyoverdine that already transported iron into the bacterial periplasm and any pyoverdine–metal complex other than ferri‐pyoverdine present in the periplasm. This review considers how these new insights into pyoverdine biosynthesis and secretion contribute to our understanding of the role of pyoverdine in iron and metal homeostasis in fluorescent Pseudomonads.
TheTOLnetwork ofPseudomonas putidamt‐2 processes multiple environmental inputs into a narrowresponse space
Authors: Silva‐Rocha Rafael , de Lorenzo Víctor 
Published: October 2012

SummaryTheTOLsystem encoded by plasmidpWW0ofPseudomonas putidamt‐2 is able to sense a large number of both exogenous and endogenous signals as inputs for the genetic and metabolic circuit that determines the biodegradation ofm‐xylene. However, whether the enormous combinatorial space of inputs is translated into an equally variable response landscape or is processed into very few outcomes remains unclear. To address this question, we set out to define the number of states that can be obtained by a network of a given set of genes under the control of a specified regulatory circuit that is exposed to all possible combinations of inputs. To this end, theTOLnetwork and its regulatory wiring were formalized as a synchronous logicBoolean circuit that had 10 signals (i.e. pathway substrates, temperature, sugars, amino acids, metabolic regimes and global regulators) as possible inputs. The analysis of the attractors of the circuit using a satisfiability (SAT) algorithm revealed that only eight transcriptional states are reached in response to the 1024 possible combinations of stimuli. The experimental validation resulted in a refinement of the model through the addition of a previously unknown interaction that controls themetacatabolic pathway. The full induction of the twoxyloperons occurred with only 1.6% of the input combinations, which suggests that the architecture of the network allows the expression of thexylgenes only under a very narrow range of conditions. These data not only explain much of the unusual layout of theTOLcircuit but also strengthen the view of the regulatory circuits of environmental bacteria as digital decision‐making devices.
Active sulfur cycling by diverse mesophilic and thermophilic microorganisms in terrestrial mud volcanoes of Azerbaijan
Authors: Green‐Saxena A. , Feyzullayev A. , Hubert C. R. J. , Kallmeyer J. , Krueger M. , Sauer P. , Schulz H.‐M. , Orphan V. J. 
Published: October 2012

SummaryTerrestrial mud volcanoes (TMVs) represent geochemically diverse habitats with varying sulfur sources and yet sulfur cycling in these environments remains largely unexplored. Here we characterized the sulfur‐metabolizing microorganisms and activity in four TMVs in Azerbaijan. A combination of geochemical analyses, biological rate measurements and molecular diversity surveys (targeting metabolic genes aprA and dsrA and SSU ribosomal RNA) supported the presence of active sulfur‐oxidizing and sulfate‐reducing guilds in all four TMVs across a range of physiochemical conditions, with diversity of these guilds being unique to each TMV. The TMVs varied in potential sulfate reduction rates (SRR) by up to four orders of magnitude with highest SRR observed in sediments where in situ sulfate concentrations were highest. Maximum temperatures at which SRR were measured was 60°C in two TMVs. Corresponding with these trends in SRR, members of the potentially thermophilic, spore‐forming, Desulfotomaculum were detected in these TMVs by targeted 16S rRNA analysis. Additional sulfate‐reducing bacterial lineages included members of the Desulfobacteraceae and Desulfobulbaceae detected by aprA and dsrA analyses and likely contributing to the mesophilic SRR measured. Phylotypes affiliated with sulfide‐oxidizing Gamma‐ and Betaproteobacteria were abundant in aprA libraries from low sulfate TMVs, while the highest sulfate TMV harboured 16S rRNA phylotypes associated with sulfur‐oxidizing Epsilonproteobacteria. Altogether, the biogeochemical and microbiological data indicate these unique terrestrial habitats support diverse active sulfur‐cycling microorganisms reflecting the in situ geochemical environment.
Fine‐scale degrader community profiling over an aerobic/anaerobic redox gradient in a toluene‐contaminated aquifer
Authors: Larentis Michael , Hoermann Katrin , Lueders Tillmann 
Published: October 2012

SummaryHydrocarbon contaminants in groundwater can be degraded by microbes under different redox settings, forming hot spots of degradation especially at the fringes of contaminant plumes. At a tar‐oil‐contaminated aquifer in Germany, it was previously shown that the distribution of anaerobic toluene degraders as traced via catabolic and ribosomal marker genes is highly correlated to zones of increased anaerobic degradation at the lower fringe of the plume. Here, we trace the respective distribution of aerobic toluene degraders over a fine‐scale depth transect of sediments taken at the upper fringe of the plume and below, based on the analysis of 16S rRNA genes as well as catabolic markers in intervals of 3–10 cm. Well‐defined small‐scale distribution maxima of typical aerobic degrader lineages within the Pseudomonadaceae, Comamonadaceae and Burkholderiaceae are revealed over the redox gradient. An unexpected maximal abundance of 9.2 × 106 toluene monooxygenase (tmoA) genes per g of sediment was detected in the strongly reduced plume core, and gene counts did not increase towards the more oxidized upper plume fringe. This may point towards unusual ecological controls of these yet unidentified aerobic degraders, and indicates that competitive niche partitioning between aerobic and anaerobic hydrocarbon degraders in the field is not yet fully understood. These findings demonstrate the potential of catabolic marker gene assays in elaborating the ecology of contaminant plumes, which is a prerequisite for developing integrated monitoring strategies for natural attenuation.
Revealing children's implicit spelling representations
Authors: Critten Sarah , Pine Karen J. , Messer David J. 
Published: October 2012

Conceptualizing the underlying representations and cognitive mechanisms of children's spelling development is a key challenge for literacy researchers. Using the Representational Redescription model (Karmiloff‐Smith), Critten, Pine and Steffler (2007) demonstrated that the acquisition of phonological and morphological knowledge may be underpinned by increasingly explicit levels of spelling representation. However, their proposal that implicit representations may underlie early ‘visually based’ spelling remains unresolved. Children (N = 101, aged 4–6 years) were given a recognition task (Critten et al., 2007) and a novel production task, both involving verbal justifications of why spellings are correct/incorrect, strategy use and word pattern similarity. Results for both tasks supported an implicit level of spelling characterized by the ability to correctly recognize/produce words but the inability to explain operational strategies or generalize knowledge. Explicit levels and multiple representations were also in evidence across the two tasks. Implications for cognitive mechanisms underlying spelling development are discussed.
HbA2 levels in normal adults are influenced by two distinct genetic mechanisms
Authors: Menzel Stephan , Garner Chad , Rooks Helen , Spector Tim D. , Thein Swee Lay 
Published: October 2012

SummaryUsing a genome‐wide association study, we found that common inter‐individual differences in haemoglobin A2 (HbA2, α2δ2) levels are largely governed by genetic factors (42% of variability). The influence of age (1%) and sex (4%) was small. HbA2 levels were influenced by two loci: the HBS1L‐MYB locus on chromosome 6q, which has been shown to have pleiotropic effects on other haematological traits; and a second locus surrounding HBB, the gene encoding β‐globin. Our results suggest that HbA2 levels in adults are influenced by two different biological processes: one via kinetics of erythropoiesis, and the other, via competition between HBB and HBD activity.
Upregulation of IL‐6, IL‐8 and CXCL‐1 production in dermal fibroblasts by normal/malignant epithelial cells in vitro: Immunohistochemical and transcriptomic analyses
Authors: Kolář Michal , Szabo Pavol , Dvořánková Barbora , Lacina Lukáš , Gabius Hans‐Joachim , Strnad Hynek , Šáchová Jana , Vlček Čestmír , Plzák Jan , Chovanec Martin , Čada Zdeněk , Betka Jan , Fík Zdeněk , Pačes Jan , Kovářová Hana , Motlík Jan , Jarkovská Karla , Smetana Jr Karel 
Published: October 2012

AbstractBackground informationConsidering an analogy between wound healing and tumour progression, we studied chemokine and cytokine transcription and expression in normal fibroblasts by co‐culture and in situ.ResultsWhole‐genome transcriptome profiling revealed strong upregulation for the interleukin (IL)‐6, IL‐8 and the chemokine CXCL‐1 in in vitro co‐cultures of normal fibroblasts with either normal or malignant epithelial cells compared to fibroblast cultures. The same ILs/chemokines were distinctly upregulated in clinical samples of squamous cell carcinoma when compared with paired normal mucosae. Analysis of culture supernatants showed that during the course of co‐culture of the fibroblasts with the epithelial cells, IL‐6, IL‐8 and CXCL‐1 were secreted to the culture medium. Experiments with addition of any of the proteins to the culture medium supported the notion that these ILs/chemokines strongly contributed to maintenance of a low‐differentiation phenotype of epithelial cells, evaluated by the detection of keratin‐8. Simultaneous addition of all factors increased the extent of the effect. These studies were extended by experiments with epithelial cells, either cultured in medium conditioned by preceding use for malignant keratinocytes without and in the presence of normal or cancer‐associated fibroblasts or medium containing antibodies against IL‐6, IL‐8 and CXCL‐1.ConclusionsOur results indicate an analogy between wound healing and tumour growth, support the importance of epithelial–mesenchymal interaction in this model system and establish a potential bio‐inspired anticancer therapy.