bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards a therapeutic window of D2/3 occupancy for treatment of psychosis in Alzheimer's disease, with [18F]fallypride positron emission tomography
Authors: Clark‐Papasavas Chloe , Dunn Joel T. , Greaves Suki , Mogg Andrew , Gomes Rosemary , Brownings Stuart , Liu Kathy , Nwosu Bonnita , Marsden Paul , Joemon John , Cleij Marcel , Kessler Robert , Howard Robert , Reeves Suzanne 
Published: February 2014

ObjectiveDopamine D2/3 receptor positron emission tomography tracers have guided antipsychotic prescribing in young people with schizophrenia by establishing a ‘therapeutic window’ of striatal D2/3 receptor occupancy. Older people, particularly those with dementia, are highly susceptible to motor side effects and may benefit from the appropriate application of imaging techniques. The study aimed to adapt [18F]fallypride imaging for use in occupancy studies in Alzheimer's disease (AD) and to investigate whether data acquisition could be made more tolerable by piloting the protocol in a small sample.MethodsSix participants with AD (three men; 85.0 ± 5.6 years old; MMSE = 16.0 ± 2.4) were recruited prior to commencing amisulpride for the treatment of psychosis and associated agitation. [18F]fallypride binding potential (BPND) was determined using an interrupted scanning protocol at baseline (n = 6) and after 27.0 ± 6.1 days of amisulpride (25–50 mg) treatment (n = 4). D2/3 occupancy was calculated by percentage reduction in BPND between scanning sessions. Image data were re‐analysed after reducing individual sampling times to 20 min.ResultsThe protocol was tolerated well, apart from the final (40 min) session of the post‐treatment scan in one participant. Higher occupancies were achieved in the striatum (caudate 47–70%, putamen 31–58%) and thalamus (54–76%) than in the inferior temporal gyrus (27–43%). There was high agreement between occupancy values derived using longer and shorter sampling times (mean absolute difference 6.1% in the inferior temporal gyrus; <2% all other regions).ConclusionsThe protocol is feasible for use in AD and represents the first step towards establishing dose–occupancy relationships across older clinical populations. Copyright © 2014 John Wiley & Sons, Ltd.
Abuse of older persons with dementia by family caregivers: results of a 6‐month prospective study in Hong Kong
Authors: Yan Elsie 
Published: February 2014

ObjectiveTo examine the association between care recipients' agitated behaviors, family caregivers' burnout, and abuse in community dwelling older Chinese with dementia in Hong Kong.DesignThis was a 6‐month prospective study.MethodOne hundred forty‐nine caregivers provided information on their demographic characteristics, care recipients' everyday functioning and agitated behaviors, and caregivers' burnout symptoms. Caregivers were re‐interviewed 6 months later and provided information on changes in both care recipients' everyday functioning and agitated behaviors, and verbally and physically abusive behaviors directed at care recipients in the past month.ResultsThe single most significant variable in predicting abuse at 6‐month follow‐up was abuse at baseline. In addition, verbal abuse was predicted by more co‐residing days, a high level of agitated behavior, and a strong sense of caregiver depersonalization. Care recipients were more likely to be physically abused if they were male, had no chronic conditions other than dementia, and demonstrated a high level of agitated behaviors. Entering caregiver burnout into the model did not modify the association between care recipients' agitated behavior and abuse for either verbal or physical abuse.ConclusionThis study is the first to establish an association between care recipients' agitated behaviors, burnout, and abuse by family caregivers using prospective data. The present results confirmed that care recipients' agitated behaviors and caregivers' symptoms of burnout are associated with family caregivers' abusive behaviors. Caregiver burnout did not mediate the association between agitated behaviors and abuse. Proper management of care recipients' agitated behaviors and adequate support provided to family caregivers may help prevent the development of new cases of elder mistreatment. Copyright © 2014 John Wiley & Sons, Ltd.
The Effect of Medicaid on Health Care Consumption of Young Adults
Authors: Coey Dominic 
Published: February 2014

SummaryAll states provide Medicaid until the age of 19 years. After 19 years, young adults may become ineligible for Medicaid. Using the Medical Expenditure Panel Survey, we find that the resulting loss of Medicaid coverage causes substantial changes to the level and composition of health care use. The total number of visits to health care providers falls by over 60%, two‐thirds of which is due to a decline in office visits. Expenditures, in particular inpatient expenditures, also appear to fall sharply. Copyright © 2014 John Wiley & Sons, Ltd.
A Functional N‐terminal Domain in C/EBPβ‐LAP* is Required for Interacting with SWI/SNF and to Repress Ric‐8B Gene Transcription in Osteoblasts
Authors: Aguilar Rodrigo , Grandy Rodrigo , Meza Daniel , Sepulveda Hugo , Pihan Philippe , van Wijnen Andre J. , Lian Jane B. , Stein Gary S. , Stein Janet L. , Montecino Martin 
Published: February 2014

ABSTRACTThe chromatin remodeling complex SWI/SNF and the transcription factor C/EBPβ play critical roles in osteoblastic cells as they jointly control transcription of a number of bone‐related target genes. The largest C/EBPβ isoform, LAP*, possesses a short additional N‐terminal domain that has been proposed to mediate the interaction of this factor with SWI/SNF in myeloid cells. Here we examine the requirement of a functional N‐terminus in C/EBPβ‐LAP* for binding SWI/SNF and for recruiting this complex to the Ric‐8B gene to mediate transcriptional repression. We find that both C/EBPβ‐LAP* and SWI/SNF simultaneously bind to the Ric‐8B promoter in differentiating osteoblasts that repress Ric‐8B expression. This decreased expression of Ric‐8B is not accompanied by significant changes in histone acetylation at the Ric‐8B gene promoter sequence. A single aminoacid change at the C/EBPβ‐LAP* N‐terminus (R3L) that inhibits C/EBPβ‐LAP*‐SWI/SNF interaction, also prevents SWI/SNF recruitment to the Ric‐8B promoter as well as C/EBPβ‐LAP*‐dependent repression of the Ric‐8B gene. Inducible expression of the C/EBPβ‐LAP*R3L protein in stably transfected osteoblastic cells demonstrates that this mutant protein binds to C/EBPβ‐LAP*‐target promoters and competes with the endogenous C/EBPβ factor. Together our results indicate that a functional N‐terminus in C/EBPβ‐LAP* is required for interacting with SWI/SNF and for Ric‐8B gene repression in osteoblasts. J. Cell. Physiol. 229: 1521–1528, 2014. © 2014 Wiley Periodicals, Inc.
FLRT2 Interacts With Fibronectin in the ATDC5 Chondroprogenitor Cells
Authors: Flintoff K.A. , Arudchelvan Y. , Gong Siew‐Ging 
Published: February 2014

ABSTRACTExpression studies have implicated FLRT2 in cranial neural crest cell migration and prechondrogenic cell condensation during craniofacial skeletogenesis. We aimed to determine whether FLRT2 was involved in mediating cell‐matrix interactions in the ATDC5 chondroprogenitor cell line. Immunolocalization experiments of ATDC5 cells revealed that FLRT2 was present on the cell membrane as well as extracellularly, where it colocalized with Fibronectin (Fn). After cell extraction of the matrix, FLRT2 was identified in the ATDC5‐derived extracellular matrix (ECM) and was further found to be associated with Fn‐coated beads in cell cultures. Blockage of Fn fibril formation via a blocking peptide resulted in a concomitant decrease in extracellular FLRT2 accumulation. Over a 7‐day period following the replenishment of the Fn blocking peptide to the cultures, there was a partial rebound in Fn fibril formation that was accompanied by a concomitant reappearance of FLRT2 co‐expression. Co‐immunoprecipitation confirmed that FLRT2 and Fn interacted, either directly or indirectly. Immunoprecipitation and Western blot analyses with antibodies recognizing epitopes located on the extra‐ and intracellular domains of FLRT2 further revealed the presence of different sized bands, suggesting that FLRT2 may exist in both membrane‐bound and shed forms. Our data therefore provide evidence that FLRT2 and/or its cleavage products may be cooperating with Fn and other ECM proteins to regulate critical cellular events. Further studies will be necessary in delineate more precisely the roles of FLRT2 in mediating cell‐ and cell‐matrix interactions during normal development. J. Cell. Physiol. 229: 1538–1547, 2014. © 2014 Wiley Periodicals, Inc.
Rare malignant pediatric tumors registered in the German Childhood Cancer Registry 2001–2010
Authors: Brecht Ines B. , Bremensdorfer Claudia , Schneider Dominik T. , Frühwald Michael C. , Offenmüller Sonja , Mertens Rolf , Vorwerk Peter , Koscielniak Ewa , Bielack Stefan S. , Benesch Martin , Hero Barbara , Graf Norbert , ∨on Schweinitz Dietrich , Kaatsch Peter 
Published: February 2014

BackgroundThe German Childhood Cancer Registry (GCCR) annually registers approximately 2,000 children diagnosed with a malignant disease (completeness of registration >95%). While most pediatric cancer patients are diagnosed and treated according to standardized cooperative protocols of the German Society for Pediatric Oncology and Hematology (GPOH), patients with rare tumors are at risk of not being integrated in the network including trials and reference centers.ProcedureA retrospective analysis of all rare extracranial solid tumors reported to the GCCR 2001–2010 (age <18 years) was undertaken using a combination of the International Classification of Childhood Cancer (ICCC‐3) and the International Classification of Diseases‐Oncology (ICD‐O‐3). Tumors accounting for <0.3% of all malignancies were defined as rare (approx. 6 cases/year and registered malignancy).ResultsAccording to this definition 1,189 rare extracranial solid tumors (18.2% of all malignant extracranial solid tumors) were registered, among these 232 patients (19.5% of rare tumor cases), were not included in preexisting GPOH studies/registries. Within 10 years, the number of registered non‐GPOH‐trial patients with a rare tumor increased.ConclusionsThough most of the GCCR‐registered patients with rare malignant tumors are treated within GPOH trials, there is a considerable number of patients that have been diagnosed and treated outside the structures of the GPOH. These patients should be reported to the recently founded German Pediatric Rare Tumor Registry (STEP). Active data accrual and the development of appropriate structures will allow for better registration and improvement of medical care in these patients. Pediatr Blood Cancer 2014;61:1202–1209. © 2014 Wiley Periodicals, Inc.
Primary service outage and secondary service performance in cognitive radio networks
Authors: Talebi Sayed Pouria 
Published: February 2014

AbstractIn this work, we have used stochastic geometry to analyze the effects of the radio environment and the secondary service sensing error on the primary service outage probability. We have also obtained a closed form expression for the primary service outage probability in a Rayleigh fading channel. Furthermore, an approximation was formulated for a general fading channel. The results obtained were used to drive an expression for the secondary service successful transmission density. Finally, we formulated an optimization problem to achieve highest density of secondary service successful transmissions while keeping the primary service outage probability in check by adjusting sensing error and secondary service node density to their optimal values. Copyright © 2014 John Wiley & Sons, Ltd.
A Genetic Counseling Intervention to Facilitate Family Communication About Inherited Conditions
Authors: Gaff Clara , Hodgson Jan 
Published: February 2014

AbstractThis paper describes the development and implementation of the first intervention to facilitate family communication of genetic information based on a genetic counseling model of practice. The intervention is telephone‐based and therefore designed to complement face‐to‐face genetic counseling consultations. It was developed by firstly reviewing the literature and a model of genetic counseling practice, leading to definition of seven core principles underpinning the intervention. A counseling framework based on these principles was developed through iterative role playing and review, tested for consistency with good practice and piloted on ten study participants. It was found to be feasible to implement and consistent with good genetic counseling practice. Implementation included training of the genetic counselors who would deliver the intervention as part of a randomized controlled trial. Noteworthy deviations from good genetic counseling practice were observed, with unexpected additional insights into the ‘black box’ of genetic counseling that may have wider implications and would benefit from further investigation. The intervention is currently being evaluated in a randomized controlled trial, to assess its impact on the number of family members attending genetic services.
Birth Cohort and the Specialization Gap Between Same-Sex and Different-Sex Couples
Authors: Giddings Lisa , Nunley John M. , Schneebaum Alyssa , Zietz Joachim 
Published: February 2014

AbstractWe examine differences in household specialization between same-sex and different-sex couples within and across three birth cohorts: Baby Boomers, Generation X, and Generation Y. Using three measures of household specialization, we find that same-sex couples are less likely than their different-sex counterparts to exhibit a high degree of specialization. However, the “specialization gap” between same-sex and different-sex couples narrows across birth cohorts. These findings are indicative of a cohort effect. Our results are largely robust to the inclusion of a control for the presence of children and for subsets of couples with and without children. We provide three potential explanations for why the specialization gap narrows across cohorts. First, different-sex couples from more recent birth cohorts may have become more like same-sex couples in terms of household specialization. Second, social and legal changes may have prompted a greater degree of specialization within same-sex couples relative to different-sex couples. Last, the advent of reproductive technologies, which made having children easier for same-sex couples from more recent birth cohorts, could result in more specialization in such couples relative to different-sex couples.
Back to Basics: Speak Up
Authors: Spruce Lisa 
Published: February 2014

AbstractBeing able to identify problems and bring them to the attention of OR team colleagues is crucial for the safety of both patients and perioperative team members; however, being able to do this means being comfortable with speaking up under circumstances that may be difficult. Disruptive or intimidating coworker behavior also makes speaking up difficult, but it is important to address in the interest of providing safe, effective care to patients. To remedy this, health care workers should create awareness of the problem and motivate others to take action; establish a culture of respect; set expectations to help eliminate disrespectful behavior; and create a learning environment that eliminates hierarchical structures, fosters professionalism, demonstrates respect, and enforces a zero tolerance policy.
Using Preoperative Assessment and Patient Instruction to Improve Patient Safety
Authors: Allison Jan , George Michelle 
Published: February 2014

AbstractRates of patient transfers, cancellations, and patient visits to the emergency department after discharge are quality metrics for ambulatory surgery centers. To improve these metrics, it is imperative to establish best practices for conducting preoperative assessments, including identifying key patient conditions (ie, obstructive sleep apnea, cardiovascular disease, reactive airway disease, obesity). To guide appropriate patient selection, practitioners should review the patient's allergies and sensitivities, alcohol use, medications, and medical history. To help ensure good patient outcomes, it is imperative to provide complete preoperative instructions (eg, NPO guidelines, medications, what to bring, cancellation instructions) and discharge instructions (eg, postoperative medications, appropriate activity restrictions, diet, surgical and anesthetic side effects, special circumstances [eg, regional blocks], symptoms of possible complications, treatment and tests, access to postdischarge follow‐up care). Generally, the routine outpatient surgical patient is discharged home; however, there are circumstances that occasionally necessitate transfer or admission to a higher level of care. For transfers, ambulatory surgery centers should adhere to applicable federal and state guidelines and should have a clear policy in place to guide transfers.
Correlation between the ore formation processes in the Berezitovoe gold–complex-metal deposit (western part of the Selenga–Stanovoy superterrane) and the regional tectonomagmatic events
Authors: Sorokin A.A. , Ponomarchuk V.A. , Travin A.V. , Rogulina L.I. , Ponomarchuk A.V. 
Published: February 2014

Abstract
The age of the major igneous complexes in the western part of the Selenga–Stanovoy superterrane has been estimated by 40Ar/39Ar dating: trachyandesite-basalts of the Kuitun (Chichatka) complex—259.4 ± 6.2 Ma; gabbro of the Tukuringra complex—156.3 ± 4.8 Ma; granites and pegmatites of the Tukuringra complex—153.1 ± 3.8, 154.0 ± 4.4, 156.8 ± 4.0, and 151.2 ± 3.2 Ma; granodiorites, granites, and leucogranites of the Amudzhikan complex—131.7 ± 2.4, 134.5 ± 2.8, and 131.6 ± 4.2 Ma; and lamprophyre dikes—125.2 ± 2.4 and 125.2 ± 3.4 Ma. Two stages of hydrothermal ore formation process have been recognized: 132–131 and ~ 125 Ma. It is shown that the deposit formation and superposed processes follow the general regularities of the Late Mesozoic evolution of the Pacific Asia margin.
Crustal structure in the Polar sector of the Urals folded system (from DSS data)
Authors: Druzhinin V.S. , Rakitov V.A. , Osipov V.Yu. , Nachapkin N.I. , Nedyad’ko V.V. 
Published: February 2014

Abstract
A 450 km long composite crustal section of the Urals folded system at 67° N and 60-69° E has been compiled from seismic data on the Polar Urals transect and the results of targeted studies. The main elements of the subsurface structure at more southerly latitudes are preserved for this cross section. The general deep-seated structure is divided into the western and eastern branches. The western one has a northwestern trend and corresponds to the West Urals megazone. The eastern one, with a northeastern trend, includes the Central Urals and East Urals megazones.
A Search for Long-Period Variables in Globular Clusters: M22 and IC4499
Authors: Sahay A. , Lebzelter T. , Wood P. R. 
Published: February 2014

AbstractWe report on the results of a long time photometric monitoring of the two metal-poor Galactic globular clusters, M22 and IC4499, searching for long-period variables (LPVs) on the upper giant branch. We detected 22 new LPVs in the field of M22 and confirmed the variability of six known variables. Periods could be determined for 16 of them. In the field of IC4499 we detected and characterised two new LPVs. Cluster membership is evaluated for all the variables based on photometry and literature data, and the location of the stars in logP-K-diagram is discussed. Our findings give further support to the presence of LPVs at metallicities as low as [Fe/H] = −1.7. The luminosity range where LPVs are found in metal-poor clusters is lower than in more metal-rich clusters.
Local Stellar Kinematics from RAVE data – V. Kinematic Investigation of the Galaxy with Red Clump Stars
Authors: Karaali S. , Bilir S. , Ak S. , Gökçe E. Yaz , Önal Ö. , Ak T. 
Published: February 2014

AbstractWe investigated the space velocity components of 6 610 red clump (RC) stars in terms of vertical distance, Galactocentric radial distance and Galactic longitude. Stellar velocity vectors are corrected for differential rotation of the Galaxy which is taken into account using photometric distances of RC stars. The space velocity components estimated for the sample stars above and below the Galactic plane are compatible only for the space velocity component in the direction to the Galactic rotation of the thin disc stars. The space velocity component in the direction to the Galactic rotation (Vlsr) shows a smooth variation relative to the mean Galactocentric radial distance (Rm), while it attains its maximum at the Galactic plane. The space velocity components in the direction to the Galactic centre (Ulsr) and in the vertical direction (Wlsr) show almost flat distributions relative to Rm, with small changes in their trends at Rm ~ 7.5 kpc. Ulsr values estimated for the RC stars in quadrant 180° < l ⩽ 270° are larger than the ones in quadrants 0° < l ⩽ 90° and 270° < l ⩽ 360°. The smooth distribution of the space velocity dispersions reveals that the thin and thick discs are kinematically continuous components of the Galaxy. Based on the Wlsr space velocity components estimated in the quadrants 0° < l ⩽ 90° and 270° < l ⩽ 360°, in the inward direction relative to the Sun, we showed that RC stars above the Galactic plane move towards the North Galactic Pole, whereas those below the Galactic plane move in the opposite direction. In the case of quadrant 180° < l ⩽ 270°, their behaviour is different, i.e. the RC stars above and below the Galactic plane move towards the Galactic plane. We stated that the Galactic long bar is the probable origin of many, but not all, of the detected features.
Postprandial activation of metabolic and inflammatory signalling pathways in human peripheral mononuclear cells
Authors: Ehlers Kerstin , Brand Tina , Bangert Adina , Hauner Hans , Laumen Helmut 
Published: February 2014

High-fat, high-carbohydrate (HFHC) meals induce an inflammatory response in mononuclear cells (MNC). Here, we studied the interaction between metabolic and inflammatory signalling pathways by the measurement of postprandial effects of three different test meals on intracellular Akt, S6 kinase (S6K)/mammalian target of rapamycin and NF-κB signalling in human MNC. We recruited six healthy, lean individuals. Each individual ingested three different meals in the morning separated by at least 3 d: a HFHC meal; an oral lipid-tolerance test meal; a healthy breakfast. Blood samples were obtained before and 1, 2, 4, 6 and 8 h after ingestion. Plasma insulin and IL-6 levels were measured. Intracellular metabolic and inflammatory signalling pathways were assessed by measuring the phosphorylation of Akt kinase and S6K, the degradation of inhibitory κB-α (IκB-α) protein and the DNA binding activity of NF-κB in MNC. mRNA expression levels of the Akt and NF-κB target genes Mn superoxide dismutase (MnSOD), CC-chemokine-receptor 5 (CCR5), intercellular adhesion molecule 1 (ICAM-1) and plasminogen activator inhibitor-1 (PAI-1) were measured by quantitative RT-PCR. We found a positive correlation of Akt phosphorylation with NF-κB activation (NF-κB binding activity: r 0·4500, P= 0·0003; IκB-α protein levels: r − 0·5435, P< 0·0001), a negative correlation of plasma insulin levels with NF-κB binding activity (r − 0·3993, P= 0·0016) and a positive correlation of plasma insulin levels with S6K activation (r 0·4786, P< 0·0001). The activation of Akt and pro-inflammatory NF-κB signalling was supported by the up-regulation of the respective target genes MnSOD and CCR5. In conclusion, the present data suggest a postprandial interaction between the metabolic and inflammatory signalling pathways Akt and NF-κB in MNC.