bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive value of bile acids as metabolite biomarkers for gallstone disease: A systematic review and meta-analysis
Authors: Han Xu , Wang Juan , Wu Yingnan , Gu Hao , Zhao Ning , Liao Xing , Jiang Miao 
Published: July 2024

Background
The profiles of bile acids (BAs) in patients with gallstone disease (GSD) have been found to be altered markedly though in an inconsistent pattern. This study aims to characterize the variation of the BA profiles in GSD patients, thereby to discover the potential metabolite biomarkers for earlier detection of GSD.

Methods
Literature search of eight electronic database in both English and Chinese was completed on May 11, 2023. The qualitative and quantitative reviews were performed to summarize the changes of BA profiles in GSD patients compared with healthy subjects. The concentrations of BAs were adopted as the primary outcomes and the weighted mean differences (WMDs) and 95% confidence interval (CI) were generated by random-effects meta-analysis models.

Results
A total of 30 studies were enrolled which included 2313 participants and reported the 39 BAs or their ratios. Qualitative review demonstrated serum Taurocholic Acid (TCA), Glycochenodeoxycholic acid (GCDCA), Glycocholic acid (GCA), Taurochenodeoxycholic acid (TCDCA), Glycodeoxycholic acid (GDCA) and Deoxycholic acid (DCA) were significantly increased in GSD patients compared with healthy subjects. Meta analysis was performed in 16 studies and showed that serum Total BAs (TBA) (WMD = 1.36μmol/L, 95%CI = 0.33; 2.4) was elevated however bile TBA (WMD = -36.96mmol/L, 95%CI = -52.32; -21.6) was declined in GSD patients. GCA (WMD = 0.83μmol/L, 95%CI = 0.06; 1.6) and TCA (WMD = 0.51μmol/L; 95%CI = 0.18; 0.85) were both increased in serum sample; TCDCA (WMD = 2.64mmol/L, 95%CI = 0.16; 5.12) was rising, however GCDCA (WMD = -13.82mmol/L, 95%CI = -21.86; -5.78) was falling in bile sample of GSD patients. The level of serum DCA in the GSD patients was found to be increased by using chromatography, yet decreased by chromatography mass spectrometry.

Conclusion
The profiles of BAs demonstrated distinctive changes in GSD patients compared with healthy control subjects. Serum GCA, TCA and GCDCA, as the typically variant BAs, presented as a potential marker for earlier diagnosis of GSD, which could facilitate early prophylactic intervention. Yet, further validation of these biomarkers by longitudinal studies is still warranted in the future.
PROSPERO registration number CRD42022339649.
Experiences of food insecurity in the Roma population before and during the COVID-19 lockdown in Spain
Authors: Soares Panmela , Molins Betlem Heras , Martínez Milán Mª Asunción , Rodríguez Camacho Mª Félix , Clemente-Gómez Vicente , Comino Iris , Davó-Blanes Mª Carmen 
Published: July 2024

Objective
To explore the food insecurity experienced by the Roma population of the Valencian Community (Spain) and the effect of the COVID-19 lockdown.

Method
Quantitative, cross-sectional exploratory study using a questionnaire that collected information on socioeconomic status and situations of food insecurity experienced before and during lockdown, based on the Food Insecurity Experience Scale of the United Nations Food and Agriculture Organization. The questionnaire was applied by health workers from the Roma community with people over 18 years of age. A descriptive analysis was carried out stratifying by sex, calculating Chi-square test to identify differences in the variables of the experiences of food insecurity.

Results
468 people participated (57.1% women/42.9% men) who expressed: worry about a lack of food (67.3%); eating the same type of food (37.2%); not being able to eat healthy foods (34.4%); feeling hungry and not being able to eat (9.6%). Around 2.1 percent stated that they could not eat for a whole day, and 65 percent reported that they had to ask for or provide help to be able to eat. When stratifying by sex, it was found that women had more experiences of food insecurity. Except in the case of having stopped eating for a full day, where the percentage remained constant, an increase was observed in the other experiences of food insecurity during lockdown.

Conclusions
A large part of the Roma population studied, especially women, experienced situations of food insecurity before COVID-19 that were aggravated during lockdown. This situation was compensated for by community support networks.
Reliability of left ventricular hemodynamic forces derived from feature-tracking cardiac magnetic resonance
Authors: Ismailov Temirlan , Khamitova Zaukiya , Jumadilova Dinara , Khissamutdinov Nail , Toktarbay Bauyrzhan , Zholshybek Nurmakhan , Rakhmanov Yeltay , Salustri Alessandro 
Published: July 2024

Background
Hemodynamic forces (HDF) analysis has been proposed as a method to quantify intraventricular pressure gradients, however data on its reliability are still scanty. Thus, the aim of this study is to assess the reliability of HDF parameters derived from cardiac magnetic resonance (CMR).

Methods
CMR studies of 25 athletes were analysed by two independent observers and then re-analysed by the same observer one week apart. Intraclass Correlation Coefficient (ICC [95% CI]) and Bland-Altman plots were used to assess association, agreement, and bias of the longitudinal (A-B) HDF, transverse (L-S) HDF, and Impulse Angle. The sample size required to detect a relative change in the HDF parameters was also calculated.

Results
In terms of inter-observer variability, there was a good correlation for the A-B and L-S (ICC 0.85 [0.67–0.93] and 0.86 [0.69–0.94]; p<0.001 for both, respectively) and a moderate correlation for the Impulse Angle (ICC 0.73 [0.39–0.87]; p = 0.001). For intra-observer variability, A-B and L-S showed excellent correlation (ICC 0.91 [0.78–0.93] and 0.93 [0.83–0.97]; p<0.001 for both, respectively). Impulse Angle presented good correlation (ICC 0.80 [0.56–0.90]; p<0.001). Frame selection and aortic valve area measurements were the most vulnerable step in terms of reliability of the method. Sample size calculation to detect relative changes ranged from n = 1 to detect a 15% relative change in Impulse Angle to n = 171 for the detection of 10% relative change in A-B HDF.

Conclusions
The results of this study showed a low inter- and intra-observer variability of HDF parameters derived from feature-tracking CMR. This provides the fundamental basis for their use both in research and clinical practice, which could eventually lead to the detection of significant changes at follow-up studies.
A Physis Natural e Sublime Tecnológico no Cinema Experimental Austríaco em Três Casos de Estudo: Arnulf Rainer (1960), Tree Again (1978) e Train Again (2021)
Authors: Bergamaschi Novaes Bárbara 
Published: July 2024

Peter Kubelka, Kurt Kren e Peter Tscherkassky representam três gerações distintas do cinema de vanguarda austríaco. Neste artigo, analisamos uma obra de cada um desses cineastas, nomeadamente, Arnulf Rainer (1960), 37/78 Tree Again (1978) e Train Again (2021), que consideramos “filmes-opúsculos” de cada uma dessas gerações. Estes trabalhos engendram um pensamento a respeito da natureza do filme e no filme, privilegiando os sentidos afectivos (hápticos) com a imagem. Neles vêm à tona a relação visceral com a matéria fílmica, nos lembrando que esta também é feita de materiais orgânicos, ou seja, é um ser vivo, por isso, suscetível à morte. Como veremos, no choque dialógico entre dois corpos – o corpus fílmico e o corpo espectatorial – surge uma manifestação da natureza (physis). Os três filmes também investigam a temporalidade, considerada uma das qualidades intrínsecas do cinema. Será justamente a partir da observação da natureza-morta e da paisagem natural que diversos artistas buscaram apreender as qualidades lábeis, impalpáveis e atmosféricas do continuum do tempo. Para além de expor como estes estudos “naturais” retornam nos filmes dos três autores austríacos, demonstramos também como eles se aproximam dos conceitos de sublime kantiano por meio de um deslocamento da experiência com as forças da natureza para as forças da tecnologia. Concluímos que cada um desses cineastas elabora, à sua maneira, novos capítulos sobre a relação entre cinema e natureza, uma relação dialética com as artes visuais, sem necessariamente chegar a uma síntese redentora. Para tal, utilizamos conceitos e escritos de Jacques Aumont, Giorgio Agamben, David E. Nye e Victor Stoichita.
Anomalía de Jordans en síndrome de Chanarin-Dorfman
Authors: Sánchez-Cortés Jorge , Gabaldó-Barrios Xavier 
Published: July 2024

Resumen

Objetivos
El síndrome de Chanarin-Dorfman es un síndrome raro de herencia autosómica recesiva cuya prevalencia no supera los 130 casos en el mundo.

Caso clínico
Paciente de 4 años afecto de síndrome ictiosiforme eritemato-descamativo generalizado desde los primeros días del nacimiento. En el informe de laboratorio destacó hipertransaminemia persistente en el tiempo. Entre otras pruebas complementarias, se realizó el frotis de sangre periférica (SP), revelando la presencia de múltiples vacuolas citoplasmáticas en el interior de los leucocitos polimorfonucleares (PMN) y plaquetas. Las lesiones ictiosiformes junto con la presencia de vacuolas lipídicas en los PMN de SP son signos compatibles con síndrome de Chanarin-Dorfman. El diagnóstico se confirmó mediante secuenciación genética.

Conclusiones
El síndrome de Chanarin-Dorfman está caracterizado por una mutación del gen CGI-58, el cual está implicado en el catabolismo de los triglicéridos de cadena larga almacenados en gotas lipídicas citoplasmáticas. La anomalía de Jordans es un rasgo congénito caracterizado por la presencia de abundantes vacuolas en la serie granulocítica debido a defectos en el metabolismo lipídico. En este síndrome, los triglicéridos de cadena larga se depositan en los tejidos produciendo principalmente manifestaciones dermatológicas controlables mediante la restricción de los mismos en la dieta.
Between Event and Object. Rhythms of Experience in Whitehead
Authors: Kong Aránguiz Felipe 
Published: July 2024

Abstract
This article seeks to clarify the role of the notion of rhythm in Whitehead’s philosophy, considering the mediating character it has between the order of events and that of objects. Deleuze and Harman, when commenting on Whitehead’s ontological system, have highlighted the value of events and objects, respectively. Here, we pretend to elucidate the limits of these readings and give relevance to the category between both planes, which is rhythm. This concepts evolve from a naturalistic view to a more metaphysical conception in Whitehead’s later work, and its applications go from science to education and aesthetics. Thus, rhythm can be understood as a complex that has an eventual face and an objectual face, internally defining itself as a system of contrasts that mobilizes creation and intensity through time. This rhythmic process of creation leads us to think a poetics of experience, considering its aesthetic and compositional nature.
The Artist and the Community: The Subversion of the Nude
Authors: Skagestad Peter 
Published: July 2024

Abstract
Collingwood’s concept of corruption of consciousness is introduced, followed by an extended example from art history. While the typical Renaissance nude enabled, or even encouraged, corruption of consciousness on the part of the male spectator, the nudes by Goya and Manet led the viewer to confront his disowned feelings, thus serving as a medicine for the corruption of consciousness. Finally, I examine the role of corruption of consciousness in the treatment of antisemitism in Elia Kazan’s 1947 film Gentleman’s Agreement.
Effects of different decaffeination methods on caffeine contents, physicochemical, and sensory properties of coffee
Authors: Shofinita Dian , Lestari Dianika , Purwadi Ronny , Sumampouw Giovanni A. , Gunawan Karen C. , Ambarwati Sekar A. , Achmadi Amarthya B. , Tjahjadi Jason T. 
Published: July 2024

Abstract
Coffee consumption could provide various benefits for human health, but also could contribute to several health problems. The growing trend of coffee consumption has created a rising demand for decaffeinated coffee that is safe for consumers with low caffeine tolerance. Decaffeination process, however, can result in the alteration of several properties of coffee which affect overall coffee taste. This review discussed current decaffeination methods such as water decaffeination, solvent decaffeination, supercritical decaffeination, and biodecaffeination which includes their mechanisms, benefits, and drawbacks as well as their effect in the physicochemical and sensory characteristics of coffee. Solvent decaffeination has showed potential improvements in the future such as the incorporation of membrane and ultrasonic technology. In addition, the mathematical model for caffeine diffusion has been arranged according to Fick’s second law of diffusion, based upon spherical and rectangular coordinates with several assumptions. Further research should be aimed to maintain the properties of coffee after decaffeination process. Furthermore, utilizing new solvents that are safe and non-toxic will potentially be favorable research in the development of decaffeination methods in the future.
Voluminous hiatal hernias – the role of robotic surgery
Authors: Dosch Michel , Chevallay Mickael , Jung Minoa K. , Mönig Stefan 
Published: July 2024

Abstract
Robotic surgery has become increasingly prevalent in UGI surgery over the last decade, particularly for treating hiatal hernias. Voluminous hiatal hernias, defined as the herniation of 30–50 % of the stomach into the thorax, often require surgical intervention due to associated dysphagia and potential severe complications. Given the challenges of repairing voluminous hiatal hernias, especially in elderly and fragile patients, the surgical technique should be optimal. Robotic surgery affords excellent visualization, allowing high mediastinal dissection and precise hiatus reconstruction. Despite the clear technical advantages, it remains to be demonstrated if the robotic approach matches the outcomes of conventional laparoscopic techniques. We review here the fundamentals of hiatal hernia surgery and describe our surgical technique using the da Vinci Xi robot to operate voluminous hiatal hernias. Additionally, we performed a systematic research analysis and selected recent publications focusing on robotic surgery for voluminous hiatal hernias. Recent studies report comparable complication rates, recurrence, and hospital stay lengths between robotic and laparoscopy surgery. Initial robotic procedures had longer operative times, which decreased with surgeon experience. Most of the studies were observational and retrospective, reporting the experience of a single center. Robotic surgery appears to be a viable option with similar complications rates to laparoscopic surgery under optimized conditions. Current literature supports the broader adoption of robotic surgery for voluminous hiatal hernias. However, prospective randomized studies are needed to further validate its use.
Reflection length at infinity in hyperbolic reflection groups
Authors: Lotz Marco 
Published: July 2024

Abstract
In a discrete group generated by hyperplane reflections in the 𝑛-dimensional hyperbolic space, the reflection length of an element is the minimal number of hyperplane reflections in the group that suffices to factor the element.
For a Coxeter group that arises in this way and does not split into a direct product of spherical and affine reflection groups, the reflection length is unbounded.
The action of the Coxeter group induces a tessellation of the hyperbolic space.
After fixing a fundamental domain, there exists a bijection between the tiles and the group elements.
We describe certain points in the visual boundary of the 𝑛-dimensional hyperbolic space for which every neighbourhood contains tiles of every reflection length.
To prove this, we show that two disjoint hyperplanes in the 𝑛-dimensional hyperbolic space without common boundary points have a unique common perpendicular.
Personalized resource recommendation method of student online learning platform based on LSTM and collaborative filtering
Authors: Zhang Zhenpeng 
Published: July 2024

Abstract
Online education resources are more and more abundant, which brings some challenges to learners’ personalized selection. How to provide personalized recommendation services from massive resources according to the needs of learners has gradually become the focus of scholars’ research. Therefore, this article improves the traditional collaborative filtering recommendation algorithm and constructs a personalized recommendation model of an online learning platform based on a long-term memory network and collaborative filtering. First, the stack noise reduction autoencoder combined with auxiliary information is used to extract the user potential vector, and the project potential vector is extracted by using the short-duration memory network and the attention mechanism. Then, the double attribute scoring matrix is used to divide the attributes, and the backpropagation network is used to predict the scores. Through the experimental analysis, the hit rate and recall rate of the model constructed by the research institute are 0.7548 and 0.7247, respectively, and the cumulative gain of normalized loss and running time are 0.3385 and 2.72 s, respectively. This model can effectively make up for the defects of the traditional algorithm caused by cold start and sparse score data and provide more effective and high-quality learning resource recommendations for students.
Ovarian hyperthecosis in adolescent females: two case reports and a review of the literature
Authors: Angley Eleanor , Vollenhoven Beverley , White Mary 
Published: July 2024

Abstract

Objectives
Ovarian hyperthecosis (OHT) is a rare cause of severe hyperandrogenism in the adolescent age group. We describe two case reports, and present an approach to management in this age group based on a review of the literature.

Case presentation
Patient A presented at age 13 years with a 2 year history of androphonia and hirsuitism. Her testosterone level was elevated at 8.3 nmol/L, and there was marked enlargement of her ovaries bilaterally. There were no focal adrenal or ovarian lesions identified on imaging. She was treated with a gonadotropin releasing hormone (GnRH) agonist and spironolactone with biochemical and clinical improvement. Patient B presented at age 14 years with secondary amenorrhoea, and a 2 year history of androphonia, hirsutism and androgenetic alopecia. Her testosterone level was 12 nmol/L, and a pelvic ultrasound revealed numerous follicles in each ovary which were otherwise normal in size. She was managed with GnRH agonist initially, and now continues on a combined oral contraceptive pill.

Conclusions
Ovarian hyperthecosis needs to be considered in pre-menopausal women presenting with severe hyperandrogenism, after exclusion of androgen-producing adrenal and ovarian tumours. The principles of management in this age group are gonadotropin suppression and hormone replacement.
Comprehensive review of surface contamination in nuclear waste waters: identification, quantification, and mitigation strategies
Authors: Chenniappan Thiagarajan , Devarajan Yuvarajan 
Published: July 2024

Abstract
The safety and reliability of nuclear facilities hinge critically on addressing metallic surface contamination in nuclear waste waters. This contamination poses significant hazards to the environment, human health, and the structural integrity of equipment. Key contaminants include heavy metals such as lead, cadmium, and mercury from industrial processes, and radioactive isotopes like uranium, plutonium, and cesium, which present severe radiological risks due to their formation during nuclear reactions and fuel cycles. Corrosive chemicals further exacerbate the problem by promoting the accumulation of rust and other metallic compounds. Additionally, organic contaminants from equipment leaks and microbiological elements, including fungi and bacteria, can form biofilms that accelerate the corrosion process. The objective of this review is to evaluate the various techniques used to identify and quantify these contaminants on metal surfaces, such as surface sampling and microbiological analysis. By implementing appropriate mitigation measures based on these findings, it is possible to reduce risks and ensure the safety and operational integrity of nuclear plants. This comprehensive assessment aims to provide a framework for enhancing contamination management practices in nuclear facilities.
The crystal structure of pyrrolidin-1-yl pivalate, C9H13NO4
Authors: Bogdanov Ivan P. , Stammler Hans-Georg , Tzvetkov Nikolay T. 
Published: July 2024

Abstract
C9H13NO4, orthorhombic, P212121 (no. 19), a = 5.8406(1) Å, b = 7.0840(1) Å, c = 24.3697(3) Å, V = 1,008.29(3) Å3, Z = 4, Rgt
(F) = 0.0148, wRref
(F
2) = 0.0381, T = 100.0(1) K.
Improving Antibiotic Stewardship in a Pediatric Long-term Care Facility
Authors: Safarians Gevick , Guo Rong , Weiss Irwin K. , Lin James A. 
Published: July 2024

OBJECTIVES
Antimicrobial stewardship is little studied in pediatric long-term care facilities. We sought to determine whether empirical ciprofloxacin for febrile respiratory illnesses could be safely reduced in our pediatric long-term care facility.

METHODS
All patients living in the 45-bed facility were included. A 1-year educational intervention for antimicrobial stewardship was implemented. Days of ciprofloxacin therapy, infections, microbiology, hospitalizations, other antibiotic use, methicillin-resistant Staphylococcus aureus and Clostridioides difficile infections, and mortality were recorded at regular intervals retrospectively from 5 years before intervention and prospectively for 8 years after intervention. Data were analyzed using statistical process control charts.

RESULTS
A majority of patients had tracheostomy tubes (96%) and ventilator dependence (58%). Ciprofloxacin use declined by 76% (17 to 4 days/1000 facility patient days). Antibiotic prescriptions for bacterial tracheitis decreased by 89% (38 to 4 courses per 6-month period). No increases in positive blood or urine cultures, hospitalizations, or need for hospital antibiotics were observed.

CONCLUSIONS
An antimicrobial stewardship intervention in a pediatric long-term care facility led to decreases in ciprofloxacin use, bacterial tracheitis diagnoses, and overall antibiotic use without increasing negative outcomes.