bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: PPA‐Mediated C—C Bond Formation: A Synthetic Route to Substituted Indeno[2,1‐c]quinolin‐6(7H)‐ones.
Authors: Liu Xu , Zhang Qian , Xin Xiaoqing , Zhang Rui , Zhou Fenguo , Dong Dewen 
Published: June 2013

AbstractA facile and efficient synthesis of the title compounds is developed by using readily available starting materials, mild conditions, and a wide range of substrate scope.
ChemInform Abstract: Synthesis of Pyrrolo‐[2,1‐j]quinolone Framework via Intramolecular Electrophilic ipso‐Cyclization.
Authors: Low‐Beinart Lila , Sun Xiaohan , Sidman Eli , Kesharwani Tanay 
Published: June 2013

AbstractIodine is successfully employed as electrophile for the transformation of N‐alkynoyltetrahydroisoquinolines to the alkaloid core structures.
ChemInform Abstract: Novel Synthesis of 4,4‐Difluoropyrido[4,3‐b]indoles via Intramolecular Heck Reaction.
Authors: Madaiah M. , Prashanth M. K. , Revanasiddappa H. D. 
Published: June 2013

AbstractAn efficient synthesis of the heterocyclic title system is achieved via condensation of difluoropiperidone (II) with ortho‐bromoanilines followed by intramolecular Heck reaction.
ChemInform Abstract: Asymmetric Intramolecular Oxa‐Michael Reactions of Cyclohexadienones Catalyzed by a Primary Amine Salt.
Authors: Wu Wenbin , Li Xin , Huang Huicai , Yuan Xiaoqian , Lu Junzhu , Zhu Kailong , Ye Jinxing 
Published: June 2013

AbstractInexpensive and easily prepared chiral primary diamine is an efficient catalyst for the title reaction under mild conditions.
ChemInform Abstract: Synthesis of 2‐Aryl‐1,2‐dihydrophthalazines via Reaction of 2‐(Bromomethyl)benzaldehydes with Arylhydrazines.
Authors: Aljaar Nayyef , Conrad Juergen , Beifuss Uwe 
Published: June 2013

AbstractIt provides a new, simple, and efficient approach to a number of 2‐aryldihydrophthalazines which are of biological interest.
ChemInform Abstract: N‐Nitroso Group‐Assisted Nucleophilic Aromatic Substitution of 6‐Chloropyrimidines: A Facile and Efficient Synthesis of Pyrimidine‐4,6‐ and ‐2,4‐diamines.
Authors: Jakubkiene Virginija , Zurba Justinas , Cikotiene Inga 
Published: June 2013

AbstractThe novel protocol involves N‐nitrosation of pyrimidine amines followed by nucleophilic substitution and denitrosation.
ChemInform Abstract: The Unambiguous Synthesis and NMR Assignment of 4‐Alkoxy and 3‐Alkylquinazolines.
Authors: Spulak Marcel , Novak Zdenek , Palat Karel , Kunes Jiri , Pourova Jana , Pour Milan 
Published: June 2013

AbstractContrary to previously reported results, alkylation of dihydroquinazoline (I) provides N3‐alkylated products instead of 4‐alkoxyquinazolines.
ChemInform Abstract: Synthesis of 7‐Iodo(arylsulfanyl)methyl‐7,8‐dihydro[1,3]thiazolo[2,3‐i]purinium Pentaiodide (Perchlorates) and Their Transformation into 4‐Amino‐5‐(1,3‐thiazol‐2‐yl)imidazole Derivatives.
Authors: Vas'kevich R. I. , Vas'kevich A. I. , Rusanov E. B. , Staninets V. I. , Vovk M. V. 
Published: June 2013

AbstractThe intramolecular electrophilic cyclization of 6‐allylsulfanylpurine (I) with iodine and arenesulfenyl chlorides, respectively and the subsequent behavior of the resulting fused heterocycles toward nucleophiles is explored.
ChemInform Abstract: Studies with Enamines: Route to Aminoazolopyrimidines and Arylazoazolopyrimidines.
Authors: Salaheldin Abdellatif M. , Khairou Khalid S. 
Published: June 2013

AbstractThe employment of enaminonitriles in the synthesis of substituted pyrazol‐ and triazolamines and further reactions of the products with enamines and activated methylene compounds are described.
ChemInform Abstract: Diversely Substituted Imidazo[1,2‐a]pyrazine‐8‐oxo‐3‐carbaldehydes: An Iodine‐Mediated Cyclization/Oxidation Approach.
Authors: Mishra Nigam M. , Vachhani Dipak D. , Modha Sachin G. , Van der Eycken Erik V. 
Published: June 2013

AbstractThis is an efficient and mild method for the synthesis of the title compounds.
ChemInform Abstract: A New Route to Construct 1,2‐Dihydroquinoxaline and 1,4‐Benzoxazine Derivatives Stereoselectively and Its Application to Novel Pyrazolo[1,5‐α]quinoxaline Oxides.
Authors: Zhang Dongxu , Yang Yan , Gao Meng , Shu Wenming , Wu Liuming , Zhu Yanping , Wu Anxin 
Published: June 2013

AbstractBoth 1,4‐benzoxazines (III) and quinoxalines (VIII) are obtained stereoselectively via a novel approach from easily available 2‐methylthio‐1,4‐enediones.
ChemInform Abstract: Solvent‐Free, Metal‐Free, Aza‐Prins Cyclization: Unprecedented Access to δ‐Sultams.
Authors: Clarisse Damien , Pelotier Beatrice , Fache Fabienne 
Published: June 2013

AbstractThe reaction of allyl sulfonamide (I) with various aldehydes or ketones and trimethylsilyl halides afford the halogenated δ‐sultams under solvent‐ and metal‐free conditions.
ChemInform Abstract: An Efficient Synthesis of Pyrido‐Imidazodiazepinediones.
Authors: Arama Dominique P. , Lisowski Vincent , Scarlata Eliana , Fulcrand Pierre , Maillard Ludovic T. , Martinez Jean , Masurier Nicolas 
Published: June 2013

AbstractThe synthesis of optically pure heterocyclic scaffolds (V) (12 examples) is achieved through selective C‐acylation of the aminoimidazopyridine (I) with various amino acids and subsequent intramolecular carbonylation.
ChemInform Abstract: Stereo‐ and Regioselective Synthesis of Polysubstituted Chiral 1,4‐Oxazepanes.
Authors: Bezanson Michelle , Pottel Joshua , Bilbeisi Rana , Toumieux Sylvestre , Cueto Mickael , Moitessier Nicolas 
Published: June 2013

AbstractAn efficient and stereoselective access to the 7‐membered ring system is possible via cyclization of unsaturated amino alcohols.
ChemInform Abstract: Asperterpenoid A, a New Sesterterpenoid as an Inhibitor of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B from the Culture of Aspergillus sp. 16‐5c.
Authors: Huang Xishan , Huang Hongbo , Li Hanxiang , Sun Xuefeng , Huang Huarong , Lu Yongjun , Lin Yongcheng , Long Yuhua , She Zhigang 
Published: June 2013

AbstractAsperterpenoid A (I) exhibits strong inhibitory activity against the title phosphatase (mPTPB) with an IC50 value of 2.2 μM.
ChemInform Abstract: Approach to the Core Structure of abeo‐Abietanes and Gibberellins via Stork—Danheiser Sequence Followed by Friedel—Crafts Alkylations.
Authors: Kakde Badrinath N. , Bhunia Subhajit , Bisai Alakesh 
Published: June 2013

AbstractStork—Danheiser reaction of bicyclic vinylogous esters (I) with alkoxy‐substituted arylmagnesium bromides followed by intramolecular Friedel—Crafts alkylation of the resulting cyclohexenones (III) offers a short synthesis of [6,5,6] carbocyclic frameworks.
ChemInform Abstract: Giant Electric‐Field‐Induced Strains in Lead‐Free Ceramics for Actuator Applications ‐ Status and Perspective
Authors: Jo Wook , Dittmer Robert , Acosta Matias , Zang Jiadong , Groh Claudia , Sapper Eva , Wang Ke , Roedel Juergen 
Published: June 2013

AbstractReview: 224 refs.
ChemInform Abstract: Beyond Perylene Diimides—Diazaperopyrenium Dications as Chameleonic Nanoscale Building Blocks
Authors: Basuray Ashish N. , Jacquot de Rouville Henri‐Pierre , Hartlieb Karel J. , Fahrenbach Albert C. , Stoddart J. Fraser 
Published: June 2013

AbstractReview: 57 refs.
Atomic Layer Deposition of High Performance Ultrathin TiO2 Blocking Layers for Dye‐Sensitized Solar Cells
Authors: Kim Do Han , Woodroof Mariah , Lee Kyoungmi , Parsons Gregory N. 
Published: June 2013

AbstractInvited for this month′s cover is the group of Gregory Parsons at North Carolina State University. The image shows one cycle of TiO2 atomic layer deposition (ALD), in which the sequential dosing and purging of TiCl4 and H2O forms ultrathin and conformal TiO2 films on rough FTO glass. Pinhole‐free ALD TiO2 forms a blocking layer to impede electron–hole recombination at the FTO/electrolyte interface in dye‐sensitized solar cells. The ALD process allows discrete tuning of the blocking‐layer thickness to maximize performance improvement. Read the full text of the article at 10.1002/cssc.201300067
Molecular Copper(II) Complexes Derived from Phosphonoacetic Acid: Crystal Structures and Magnetic Behavior
Authors: Mautner Franz A. , El Fallah M. Salah , Roubeau Olivier , Speed Saskia , Teat Simon J. , Vicente Ramon 
Published: June 2013

AbstractThe syntheses, structural characterization, and magnetic behavior of five new copper(II) complexes derived from phosphonoacetic acid, H2O3PCH2CO2H, with the formulae [Cu{(py)2C(OH)2}](HO3PCH2CO2H)2 (1), [Cu2(HO3PCH2CO2)2{(py)2C(OCH3)OH}2] (2), [Cu2(HO3PCH2CO2)2(bpy)2] (3), [Cu4(O3PCH2CO2)2(5‐dmbpy)4(H2O)4](NO3)2 (4), and [Cu4(O3PCH2CO2)2(5‐dmbpy)4(H2O)4](ClO4)2 (5) are reported. [H2O3PCH2CO2H = phosphonoacetic acid, (py)2C(OH)2 = bis(2‐pyridyl)methanediol, {(py)2C(OCH3)OH} = bis(2‐pyridyl)methoxymethanol, bpy = 2,2′‐dipyridyl, 5‐dmbpy = 5,5′‐dimethyl‐2,2′‐dipyridyl, terpy = 2,2′:6′,2″‐terpyridine]. Complex 1 is a mononuclear compound with hydrogenphosphonateacetic acid in its monoanionic form, complexes 2 and 3 are dinuclear compounds with hydrogenphosphonoacetate(2–) bridging ligands, and complexes 4 and 5 are tetranuclear compounds with phosphonoacetate(3–) bridging ligands. The magnetic properties of polynuclear complexes 2–5 are reported.
Straightforward Approach to Ferrocenyl Amino Acids and Peptides by Allylic Alk­ylation
Authors: Gorges Jan , Ullrich Angelika , Kazmaier Uli 
Published: June 2013

AbstractFerrocenylallyl carbonates have been found to be suitable substrates for palladium‐catalyzed allylic alkylation reactions. Amino acid ester and peptide enolates were employed as nucleophiles for the regio‐ and stereoselective introduction of the redox‐active ferrocenyl unit into peptide chains.
A study on the seismic performance of steel‐reinforced concrete frame‐concrete core wall high‐rise mixed structure by large‐scale shaking table tests and numerical simulations
Authors: Xu Ziguo , Xu Peifu , Xiao Congzhen 
Published: June 2013

SUMMARYThis paper reports a study for the seismic performance of one large‐scaled (1/15) model of 30‐story steel‐reinforced concrete frame‐concrete core wall mixed structure. The study was implemented by both shaking table tests, in which the similarity ratio for lateral and gravitational accelerations was kept to 1:1, and numerical nonlinear dynamic analysis. The test observations presented herein include story displacement, interstory drift, natural vibration periods, and final failure mode. The numerical analysis was performed to simulate the shaking table test procedure, and the numerically obtained responses were verified by the test results. On the basis of the numerical results, the progressions of structural stiffness, base shear, and overturning moment were investigated, and the distributions of base shear and overturning moment between frame and core wall were also discussed. The test demonstrates the seismic performance of the steel‐reinforced concrete frame‐core wall mixed structure and reveals the potential overturning failure mode for high rise structures. The nonlinear analysis results indicate that the peripheral frames could take more shear forces after core wall damaged under severe earthquakes. Copyright © 2013 John Wiley & Sons, Ltd.
Impacts of post‐glacial rebound on landslide spatial distribution at a regional scale in northern Iceland (Skagafjörður)
Authors: Cossart Etienne , Mercier Denis , Decaulne Armelle , Feuillet Thierry , Jónsson Helgi Páll , Sæmundsson Þorsteinn 
Published: June 2013

ABSTRACTIn de‐glaciated areas, para‐glaciation (i.e. the conditioning of landscapes by prior glaciation) has often been considered a major predisposing factor in landslide occurrence; its consequences have been particularly well identified at a fine scale (especially on bedrock jointing). Hitherto, the relative impacts of para‐glaciation on hillslope dynamics at a regional scale had nevertheless not been quantified statistically. We examine Skagafjörður area (northern Iceland) where landslides are widespread (at least 108 were mapped in an area of c. 3000 km2). We compare the role of para‐glaciation (debuttressing, influence of post‐glacial rebound) with that of classic factors (topography, lithology, etc.) in landslide occurrence and location, using a spatial analysis based on a chi‐square test. On the one hand, the results highlight that landslides are over‐represented in areas where post‐glacial rebound was at its maximum, with a stronger concentration of landslides in the northern part of the fjord. On the other hand, the distribution of landslides did not show any clear relationship with the pattern of glacial debuttressing. Tschuprow coefficient highlights that the influence of post‐glacial rebound on landslide location is higher than the combined influence of slope gradient, curvature or geological structure. This result is supported by our initial evidence for the timing of landslides in the area: most landslides occurred during the first half of the Holocene, and a period of hillslope instability was initiated when the post‐glacial uplift was at its maximum. Finally, the mechanisms that link post‐glacial rebound and landsliding as well as the geomorphic impacts of landslides, are discussed. Copyright © 2013 John Wiley & Sons, Ltd.
Cardiovascular effects induced by α‐terpineol in hypertensive rats
Authors: Sabino Carla Kelly Barroso , Ferreira‐Filho Edson Santos , Mendes Marcelo Bezerra , da Silva‐Filho José Couras , Ponte Marco Philipe Teles Reis , Moura Lucas Henrique Porfírio , Oliveira Elisangela Cláudia Alves , Quintans‐Junior Lucindo José , dos Santos Márcio Roberto Viana , de Cássia Meneses Oliveira Rita , de Oliveira Aldeídia Pereira 
Published: June 2013

ABSTRACTThe antihypertensive and antioxidant effects of α‐terpineol on hypertensive rats were evaluated in this study. Hypertension was induced in male Wistar rats by oral administration of the NG‐nitro‐L‐arginine methyl ester (L‐NAME) 50 mg/kg body weight/day) in drinking water for 1 week. Rats with mean arterial pressure > 140 mmHg were considered hypertensive. In order to evaluate the α‐terpineol effect on haemodynamic parameters, rats were treated once a day with different doses of α‐terpineol (25, 50, or 100 mg/kg/day) or vehicle for one week. After this time, blood samples were collected and activities of antioxidant enzymes were assessed. Furthermore, the vasorelaxant effect of α‐terpineol was also assessed in mesenteric artery rings. Oral administration of α‐terpineol was able to reduce mean arterial pressure in up to 38.15 ± 8.7 mmHg. In mesenteric artery rings, α‐terpineol (10−9–10−2 M) induced vascular endothelium independent vasodilatation. In addition, rats treated with α‐terpineol showed alterations in biochemical parameters indicating an antioxidant effect. Such results suggest that α‐terpineol is able to reduce arterial pressure, possibly due to a decrease of vascular resistance, and restore enzymatic antioxidants in L‐NAME‐induced hypertensive rats. Copyright © 2013 John Wiley & Sons, Ltd.
Jet grouting in tunnelling / Düsenstrahlverfahren im Tunnelbau
Authors: Trunk Ulrich , Winkler Friedrich 
Published: June 2013

AbstractIn tunnelling, jet grouting may be used for excavation support ahead of the tunnel face in situations presenting scarce overburden or insufficient rock stability. This paper discusses jet grouting (JG) applications in which the jet grouted elements are produced from within the tunnel. Exhaustive data on soil composition is a necessary condition for choosing the most suitable method, dimensioning and planning.Common applications are horizontal JG umbrella arches, JG columns reinforcing the side walls and waterproof inverts. Production sequence, column diameter, choice of tools, quality assurance and logistics must be matched to the specific boundary conditions for the execution of JG works from inside the tunnel. The range of possible solutions is here shown by presenting previous JG projects.Das Düsenstrahlverfahren (DSV) wird im Tunnelbau z.B. zur Voraussicherung des Vortriebs bei geringer Überdeckung oder nicht ausreichender Standsicherheit des anstehenden Gebirges eingesetzt. Der Beitrag stellt Einsatzmöglichkeiten des Düsenstrahlverfahrens vor, bei denen die Düsenstrahlelemente aus dem Tunnel heraus hergestellt werden. Voraussetzung für die Wahl der geeigneten Methode, Dimensionierung und Planung sind ausreichende Baugrundinformationen. Ausgeführt werden vor allem horizontale DSV‐Schirme, Säulen zur Verstärkung des Ulmengewölbes und Sohlabdichtungen. Herstellabfolge, Säulendurchmesser, Gerätetechnik, Qualitätssicherung und Logistik sind auf die besonderen Randbedingungen für die Ausführung der DSV‐Arbeiten aus dem Tunnel abzustimmen. Die Bandbreite möglicher Lösungen wird anhand ausgeführter DSV‐Arbeiten aufgezeigt.
Internal solitary wave refraction at Dongsha Atoll, South China Sea
Authors: Li Xiaofeng , Jackson Christopher R. , Pichel William G. 
Published: June 2013

AbstractInternal solitary waves (ISWs) are regularly generated at the Luzon Strait, propagate westward into the South China Sea, and dissipate on the continental shelf after persisting for more than 4 days. The Dongsha Atoll stands in the middle of their propagation path and the incident ISW bifurcates as it interacts with, and passes the atoll. As the two arms meet on the western side of Dongsha, they produce complex patterns from nonlinear internal wave interactions. In this study, new satellite observations are presented that show unusual ISW refraction patterns at the Dongsha Atoll. In these satellite images the incident wave is located on one side of Dongsha, and the portion of the wave closest to the atoll continues to propagate around the atoll circularly, while the remaining portion of the arm continues its westward propagation. The process is adequately modeled using a function relating ISW phase speed to ocean depth.
Aging and KIBRA/WWC1 genotype affect spatial memory processes in a virtual navigation task
Authors: Schuck Nicolas W. , Doeller Christian F. , Schjeide Brit‐Maren M. , Schröder Julia , Frensch Peter A. , Bertram Lars , Li Shu‐Chen 
Published: June 2013

ABSTRACTSpatial navigation relies on multiple mnemonic mechanisms and previous work in younger adults has described two separate types of spatial memory. One type uses directional as well as boundary‐related information for spatial memory and mainly implicates the hippocampal formation. The other type has been linked to directional and landmark‐related information and primarily involves the striatum. Using a virtual reality navigation paradigm, we studied the impacts of aging and a single nucleotide polymorphism (SNP rs17070145) of the KIBRA gene (official name: WWC1) on these memory forms. Our data showed that older adult's spatial learning was preferentially related to processing of landmark information, whereas processing of boundary information played a more prominent role in younger adults. Moreover, among older adults T‐allele carriers of the examined KIBRA polymorphism showed better spatial learning compared to C homozygotes. Together these findings provide the first evidence for an effect of the KIBRA rs17070145 polymorphism on spatial memory in humans and age differences in the reliance on landmark and boundary‐related spatial information. © 2013 Wiley Periodicals, Inc.
No strong temporal relationship between obesity and multisite pain – results from a population‐based 20‐year follow‐up study
Authors: Magnusson K. , Østerås N. , Mowinckel P. , Natvig B. , Hagen K.B. 
Published: June 2013

AbstractBackgroundMultisite pain and obesity are cross‐sectionally related and are common conditions that may influence each other through socio‐demographic, lifestyle and/or health‐related factors. The aim of the present study was to examine the cross‐sectional and prospective associations between overweight/obesity and multisite pain in a general population.MethodsIn a 20‐year population‐based prospective cohort study, persons aged 20–62 years in 1990 participated in postal surveys in 1990, 1994, 2004 and 2010 (n = 855). Multisite pain was defined as reporting ≥ 2 number of pain sites (NPS) on the Standardized Nordic Questionnaire. Overweight was defined as body mass index (BMI) 25–30 kg/m2 and obesity as BMI ≥ 30 kg/m2. To exploit all measurement times, generalized estimating equation analyses adjusting for age, sex, educational and occupational status, smoking, sleep quality, mental distress and physical activity were employed.ResultsThe mean age was 41 years at baseline and 57% were women. Overweight/obesity and NPS were significantly associated cross‐sectionally. Being overweight/obese was associated with reporting future NPS ≥ 2 [overweight: odds ratio (OR), 1.40, 95% confidence interval (CI), 1.12–1.75, obese: OR, 1.54, 95% CI, 1.04–2.28]. Having NPS ≥ 2 was not associated with becoming overweight, but increased the OR for future obesity (OR 1.27, 95% CI, 1.02, 1.59). Smoking was a confounder in this relationship.ConclusionsBeing overweight or obese was associated with future multisite pain, although the magnitude of the association was small and the dose‐response relationship observed in cross‐sectional analyses disappeared in prospective analyses. There was less evidence that having multisite pain was a predictor of future overweight/obesity.
Patterning human neuronal networks on photolithographically engineered silicon dioxide substrates functionalized with glial analogues
Authors: Hughes Mark A. , Brennan Paul M. , Bunting Andrew S. , Cameron Katherine , Murray Alan F. , Shipston Mike J. 
Published: June 2013

AbstractInterfacing neurons with silicon semiconductors is a challenge being tackled through various bioengineering approaches. Such constructs inform our understanding of neuronal coding and learning and ultimately guide us toward creating intelligent neuroprostheses. A fundamental prerequisite is to dictate the spatial organization of neuronal cells. We sought to pattern neurons using photolithographically defined arrays of polymer parylene‐C, activated with fetal calf serum. We used a purified human neuronal cell line [Lund human mesencephalic (LUHMES)] to establish whether neurons remain viable when isolated on‐chip or whether they require a supporting cell substrate. When cultured in isolation, LUHMES neurons failed to pattern and did not show any morphological signs of differentiation. We therefore sought a cell type with which to prepattern parylene regions, hypothesizing that this cellular template would enable secondary neuronal adhesion and network formation. From a range of cell lines tested, human embryonal kidney (HEK) 293 cells patterned with highest accuracy. LUHMES neurons adhered to pre‐established HEK 293 cell clusters and this coculture environment promoted morphological differentiation of neurons. Neurites extended between islands of adherent cell somata, creating an orthogonally arranged neuronal network. HEK 293 cells appear to fulfill a role analogous to glia, dictating cell adhesion, and generating an environment conducive to neuronal survival. We next replaced HEK 293 cells with slower growing glioma‐derived precursors. These primary human cells patterned accurately on parylene and provided a similarly effective scaffold for neuronal adhesion. These findings advance the use of this microfabrication‐compatible platform for neuronal patterning. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1350–1360, 2014.