bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy comparison of immune combination therapies in subgroups for advanced hepatocellular carcinoma patients: Systematic review and network meta-analysis
Authors: Wang Yani , Lau Wanyee , Li Yafei , Tian Yichen , Lei Yongrong , Xia Feng , Wang Jianhua 
Published: July 2024

Background
There is a lack of precision in the immunotherapy strategy tailored for patients exhibiting diverse clinical characteristics. This study aims to employ a rigorous network meta-analysis (NMA) approach to systematically evaluate the effectiveness of immune-combination therapies among patients with advanced hepatocellular carcinoma, taking into account their varying clinico-characteristics.

Methods
Studies were retrieved from PubMed, Embase, Cochrane Library, and Web of Science databases. The included first-line phase III studies were categorized into three types: immunotherapy combined with anti-angiogenetic agents, immunotherapy combined with tyrosine kinase inhibitors, and dual immunotherapy, with sorafenib serving as the control group. The primary endpoint used to assess efficacy was overall survival (OS), facilitating a comparative analysis among the three treatment modalities. Furthermore, subgroup analyses were conducted to evaluate the varying effectiveness for patients with diverse clinico-characteristics. Secondary outcome measures included progression-free survival, objective response rate, and toxicity assessment.

Results
A total of 6 studies were included in the NMA, encompassing a cohort of 3840 patients. The results revealed that immunotherapy combined with anti-angiogenetic agents exhibited a significantly enhanced therapeutic effect in terms of improving OS compared to sorafenib (HR = 0.61, 95% CrI, 0.42–0.90). Furthermore, based on various clinicopathological features, this combination therapy demonstrated superior OS responses in specific patient subgroups: BCLC C (HR = 0.63, 95% CrI, 0.42–0.93), ECOG 1 (HR = 0.57, 95% CrI, 0.36–0.91), with extrahepatic spread (EHS) (HR = 0.59, 95% CrI, 0.37–0.92), alpha fetoprotein (AFP)<400ng/ml (HR = 0.56, 95% CrI, 0.33–0.94) and viral hepatitis positivity (HR = 0.56, 95% CrI, 0.39–0.77) (especially HBV (HR = 0.58, 95% CrI, 0.40–0.85)). Importantly, the advantage of this combination therapy was even more pronounced in patients with viral hepatitis positivity. Also, the adverse events associated with immunotherapy combined with antiangiogenic drugs were moderate.

Conclusions
Immunotherapy combined with anti-angiogenetic agents could represent the most effective first-line intervention for achieving improved OS, particularly in patients with viral hepatitis positivity.
Measuring HIV outcomes for adolescent girls and young women programs in Africa: Using the polling booth survey technique
Authors: Emmanuel Faran , Aloo Lize , Mahfooz Amna , Nkuatsana Mathato , Tswetla Nametsego , Mutenda Nicolus , Mwale Biziwick , Bissek Zounkanyi , Bhattacharjee Parinita 
Published: July 2024

Introduction
Adolescent girls and young women (AGYW) remain highly vulnerable to the risk of acquiring HIV (Human immunodeficiency virus). This study was conducted to measure behavioral, biomedical and structural outcomes for the Global Fund funded AGYW programmes in five African countries with high burden of HIV including Botswana, Cameroon. Lesotho, Malawi and Namibia.

Methods
The study used a mixed methods approach to collect behavioral, structural and biomedical outcome data. Quantitative data were collected through 418 Polling Booth Survey (PBS) sessions from 4,581 AGYWs. Participants were recruited through a community-based multistage sampling technique using sampling weights for urban and rural communities. 23 Focus Group Discussions (FGD) were conducted to understand barriers to use of HIV prevention programme and community recommendations for improved coverage. Ethical approvals were obtained from the ethics review board in all five countries.

Results
More than 50% of the respondents from all five countries reported to be sexually active, and at least 30% or more of those who were sexually active had multiple sex partners. There were wide variations between the countries in condom use with a non-marital sexual partner which ranged between 66% in Namibia to 42% in Cameroon. Cameroon (44%) had high percentage of AGYWs with independent income source while school drop-outs were higher in Malawi (55.5%) and Lesotho (46.6%). Nearly 1/4th of AGYWs in all countries, except Namibia, reported experiencing intimate partner violence. Nineteen percent of the respondents were pregnant in the last 12 months, and 50% of those pregnancies were unplanned. Lesotho had the highest proportion of AGYW (90.5%) ever tested for HIV, followed by Malawi (87.5%), Botswana (75%), Cameroon (69%) and Namibia (62.6%).

Discussion
There is diversity across the countries, with country-wise and age-wise variations in results. In all countries, the AGYW programme will benefit from a more targeted approach to reach out to the most vulnerable AGYW, strengthening structural interventions, strengthening linkage to PrEP (Pre-Exposure Prophylaxis) and ART (Antiretroviral Therapy) for those who are living with HIV and a strong linkage with reproductive health services. The assessment helped countries to understand the gaps and opportunities to improve the HIV prevention programme with AGYW.
Physical therapy for muscle strengthening in individuals with amyotrophic lateral sclerosis: A protocol for a systematic review and meta-analysis
Authors: Souza Aline Alves de , da Silva Stephano Tomaz , Macedo Lorenna Raquel Dantas de , Aires Diogo Neres , Pondofe Karen de Medeiros , Melo Luciana Protásio de , Valentim Ricardo Alexsandro de Medeiros , Ribeiro Tatiana Souza 
Published: July 2024

Introduction
People with Amyotrophic Lateral Sclerosis (ALS) can present initially muscle weakness, which is a debilitating symptom that may be improved by engaging in muscle strengthening activities. Currently, the effects of motor interventions for muscle strengthening in people with ALS are unclear. This review intends to analyze the effects of motor interventions for muscle strengthening in individuals with ALS

Methods and analysis
Randomized, non-randomized, and quasi-experimental clinical trials assessing individuals with ALS of both sexes, aged 18 years or older, who have received motor interventions for muscle strengthening considering all practices that can lead to increased strength, endurance, power and muscular hypertrophy will be included. No restriction on language, location, or publication date will be applied. MEDLINE, EMBASE, Cochrane Library (CENTRAL), SPORTDiscus, and Physiotherapy Evidence Database (PEDro) databases will be searched. The US National Institutes of Health Ongoing, ClinicalTrials.gov, and the reference lists of included studies will also be searched. Two reviewers will independently screen titles and abstracts and extract data from included studies. The methodological quality of the included studies will be assessed by the PEDro scale and the certainty of the evidence by the GRADE approach. Disagreements will be resolved by a third researcher. Findings will be presented in text and table formats. A meta-analysis will compare the effects of motor interventions for muscle strengthening versus placebo or other interventions.
Effects of KRAS, STK11, KEAP1, and TP53 mutations on the clinical outcomes of immune checkpoint inhibitors among patients with lung adenocarcinoma
Authors: Liang Yao , Maeda Osamu , Kondo Chiaki , Nishida Kazuki , Ando Yuichi 
Published: July 2024

Background
This study aimed to identify the associations between individual KRAS, STK11, KEAP1, or TP53 mutations, as well as the comutation status of these genes, and the tumor mutation burden (TMB) with clinical outcomes of lung adenocarcinoma patients treated with immune checkpoint inhibitors (ICIs).

Methods
We collected data from patients with lung adenocarcinoma treated with ICIs from the Center for Cancer Genomics and Advanced Therapeutics (C-CAT) database between June 2019 and August 2023. The main endpoints were the treatment response and overall survival (OS).

Results
Among 343 patients with lung adenocarcinoma, 61 (18%), 69 (20%), 41 (12%), and 222 (65%) patients had KRAS, STK11, KEAP1, and TP53 mutations, respectively. An overall objective response was observed in 94 of 338 patients (28%), including 2 (1%) who achieved a complete response and 92 (27%) who achieved a partial response. Patients with STK11, KEAP1, or TP53 mutations had a significantly greater TMB (P<0.001). According to the univariate analysis, the treatment response was significantly correlated with TP53 mutation in both the general (P = 0.041) and KRAS wild-type (P = 0.009) populations. KEAP1 and TP53 mutations were associated with worse OS among assessable patients (hazard ratio (HR) = 2.027, P = 0.002; HR = 1.673, P = 0.007, respectively) and among patients without KRAS mutations (HR = 1.897, P = 0.012; HR = 1.908, P = 0.004, respectively). According to the multivariate analysis, KEAP1 (HR = 1.890, P = 0.008) and TP53 (HR = 1.735, P = 0.011) mutations were found to be independent factors for OS.

Conclusions
STK11, KEAP1, and TP53 mutations are significantly associated with a high TMB. TP53 mutation could affect the treatment response to some degree, and both KEAP1 and TP53 mutations resulted in inferior OS in the general patient population and in those with KRAS-wild-type lung adenocarcinoma, indicating that KEAP1 and TP53 mutations might act as prognostic factors for ICI treatment in lung adenocarcinoma patients.
Feco-prevalence, endoscopic pattern and associated factors of Helicobacter Pylori infection among symptomatic adult patients in Northern Tanzania
Authors: Muhina Ibrahim Ali Ibrahim , Sadiq Abid M. , Said Fuad H. , Raza Faryal M. , Gharib Sarah K. , Muhali Sophia S. , Costantine Andrea R. , Abdalla Mulhati S. , Shirima Laura J. , Chamba Nyasatu G. , Lyamuya Furaha S. , Mkwizu Elifuraha W. , Kilonzo Kajiru G. , Maro Venance P. , Shao Elichilia R. 
Published: July 2024

Background
Africa has consistently had the highest prevalence (70.1%) of H. pylori, and this has led to significant cases of dyspepsia, gastric cancers, and upper gastrointestinal bleeding. However, most studies have used sero-prevalence, which might not give the current state of the infection. Among the tests, the stool antigen test is simple, quick, and effective. The study aimed to determine the feco-prevalence, endoscopic pattern, and associated factors of H. pylori infection among symptomatic adult patients in Northern Tanzania.

Materials and methods
A hospital-based, cross-sectional study was conducted from October 2022 to April 2023 among adults attending the gastroenterology clinic at Kilimanjaro Chistian Medical Centre. A systematic random sampling was used to select the participants with indications of undergoing esophagogastroduodenoscopy. Questionnaires, stool and blood samples, and endoscopy were used to collect variable data. Numerical and categorical variables were summarized into narrations and tables. Logistic regression was used to assess the factors associated with H. pylori.

Results
The feco-prevalence of H. pylori was 43.4%. Chronic gastritis (51.1%) was the most common endoscopic pattern, whereas duodenal ulcers and gastric ulcers were significantly associated with H. pylori infection. Increasing in age (p <0.001) and blood group (p <0.001) were significantly associated with H. pylori infection in the adjusted analysis.

Conclusion
The feco-prevalence of H. pylori is high in this setting. H. pylori stool antigen can be used as the initial workup for symptomatic patients before the initiation of proton pump inhibitors. Additionally, due to other causes of dyspepsia, it is advised that H. pylori stool antigen testing be part of the initial evaluation and esophagogastroduodenoscopy be considered in the absence of other alarm symptoms if symptoms persist despite an appropriate trial of medical therapy.
The Routledge Companion to Global Literary Adaptation in the Twenty-First Century, B. Chua and E. Ho (eds) (2023)
Authors: Blackwell Reviewed by Anna 
Published: July 2024

Review of: The Routledge Companion to Global Literary Adaptation in the Twenty-First Century, B. Chua and E. Ho (eds) (2023)
Abingdon: Routledge, 375 pp.,
ISBN 978-0-36748-170-4, h/bk, £195
Exploring the phytochemical profile and antioxidant evaluation: Molecular docking and ADMET analysis of main compounds from three Solanum species in Saudi Arabia
Authors: Herqash Rashed N. , Alanzi Abdullah R. , Ahamad Syed Rizwan , Rehman Md. Tabish , Alharbi Mohammed S. , Alsufyani Sami A. , Al-Mishari Abdullah A. , Alqahtani Ali S. 
Published: July 2024

Abstract
This study aimed to comprehensively assess the phytochemical composition, employing gas chromatography–mass spectrometry (GC–MS) and reverse-phase high-performance liquid chromatography (RP-HPLC) analyses, molecular docking, ADMET analysis, and antioxidant activity evaluation, of three Solanum species (Solanum forsskalii [SF], Solanum villosum [SV], and Solanum incanum [SI]) from the diverse flora of Saudi Arabia. Two solvents, hydro-methanolic (HME) and hydro-acetonic extract, were utilized for extraction, finding HME more efficient, especially for SV. GC–MS analysis identified diverse compounds, with palmitic acid, linoleic acid, methyl palmitate, cis-13-octadecenoic acid, and oleic acid as the main constituents. RP-HPLC quantified 12 phenolic compounds, identifying chlorogenic acid, rutin, and p-coumaric acid as abundant. Antioxidant assays showed HME extracts to be more effective in both diphenyl 1-picrylhydrazyl and ABTS assays, with SV exhibiting the strongest antioxidant effect, followed by SF and SI. Pearson correlation analysis indicated a positive correlation between phenolic content and antioxidant activity (r = 0.6067–0.8927). Molecular docking simulations demonstrated robust binding energies between predominant compounds and Cyt-c, underscoring their potential as effective antioxidants. ADMET analysis showcased varied profiles, suggesting promising pharmaceutical prospects. This study explores the phytochemical profiles of these Solanum species, emphasizing their strong antioxidant capacity as natural sources of phenolic compounds, advancing our understanding of their promising medicinal applicability.
Preparation and characterization of Ni/Al2O3 catalyst for catalytic reduction of CO2 to formic acid in the presence of hydrazine hydrate as a hydrogen source
Authors: Ranjan Rajeev , Biswas Prakash 
Published: July 2024

Abstract
In this study, the catalytic reduction of CO2 into formic acid was investigated over a Ni/Al2O3 catalyst synthesized by wet-impregnation technique. The CO2 hydrogenation reaction was performed in a slurry reactor in the temperature range of 100–300 °C and at an autogenerated pressure. The Na2CO3 was used as a CO2 source, and hydrazine hydrate was used as a hydrogen source. The effect of reaction temperature, catalyst metal loading (5–15 wt%), and catalyst amount were optimized for the higher yield of formic acid. The catalyst was very selective to formic acid, and a very high formic acid selectivity of ∼99 % was achieved in the presence of 10 wt% Ni/Al2O3 catalyst at a much lower reaction temperature of 250 °C. The obtained formic acid yield was ∼53.5 %. The result demonstrated that the Ni/Al2O3 catalyst developed was very promising for the selective hydrogenation of CO2 molecules to formic acid via the in situ hydrogenation from hydrazine hydrate.
A Matter of Values: On the Link Between Economic Performance and Schwartz Human Values
Authors: Czupryna Marcin , Schaff Frederik 
Published: July 2024

Abstract
The goal of the paper is to propose an abstract but formalised model of how Schwartz higher order values may influence individual decisions on sharing an individual effort among alternative economic activities. Subsequently, individual decisions are aggregated into the total (collective) economic output, taking into account interactions between the agents. In particular, we explore the relationship between individual higher order values: Self-Enhancement, Self-Transcendence, Openness to Change and Conservation – measured according to Schwartz’s universal human values theory – and individual and collective economic performance, by means of a theoretical agent based model. Furthermore, based on empirical observations, Openness to Change (measured by the population average in the case of collective output) is positively associated with individual and collective output. These relations are negative for Conservation. Self-Enhancement is positively associated with individual output but negatively with collective output. In case of Self-Transcendence, this effect is opposite. The model provides the potential explanations, in terms of individual and population differences in propensity for management, willingness to change and skills (measured by an educational level) for the empirically observed relations between Schwartz higher order values and individual and collective output. We directly calibrate the micro-level of the model using data from the ninth round of the European Social Survey (ESS9) and present the results of numerical simulations.
Research progress on freeze–thaw constitutive model of concrete based on damage mechanics
Authors: Zimei Liu , Xueliang Ge , Cairong Lu , Zhengnan Zhang , Yuwei Duan , Haiyan Xu 
Published: July 2024

Abstract
In cold areas, freeze–thaw damage seriously affects the long-term use and safe operation of concrete structures. The constitutive model is an important foundation for predicting deformation and strength characteristics of concrete materials and for the non-linear analysis of concrete structures. This study is based on the elaboration of methods for the constitutive model of damaged materials by using damage mechanics and others. This study focuses on the existing constitutive model results of concrete under the static axial compression load, dynamic load, and coupling environmental load, and analyzing the problems in existing studies. Research has shown that segmented models exhibit higher fitting accuracy of concrete freeze–thaw constitutive model under static axial compression loads. By defining coupled damage variables, it is possible to approach the actual freeze–thaw damage of concrete under environmental coupling, and attention should be paid to the differences or interactions between damage factors. In order to meet the actual engineering needs of high altitude and cold areas needs to expand the temperature range of freeze–thaw tests and consider the dynamic loads impact on concrete damage, the establishment of constitutive model of concrete under the actual freeze–thaw damage is the focus of frost-resistant durability research of hydraulic concrete in cold regions.
Study on the basic properties of iron tailings powder-desulfurization ash mine filling cementitious material
Authors: Yu Feng , Chen Xing , Fang Yuan , Cao Yue , Bu Shuangshuang , Zhang Shijiang 
Published: July 2024

Abstract
To realize the recycling of iron tailings powder (IP) and desulfurization ash (DA) and reduce the high preparation cost of mine filling cementitious materials (MCs), this article adopts sodium carbonate (SC) as an activator to prepare iron tailings powder-desulfurization ash mine filling cementitious materials (IDMC). The effects of IP content, DA content, SC content, and mirabilite content on the mechanical properties and setting time are experimentally investigated. The micromorphology and phase compositions of the hydration products of IDMC are analyzed and characterized by scanning electron microscopy and X-ray diffraction. The results show that the initial setting time of the IDMC is reduced by 0.87 and 21.83% when the mirabilite content is increased from 0 to 1% and 2%, respectively, and the compressive and flexural strengths of the IDMC are increased by 24.01 and 86.25% when the IP content is increased from 0 to 20%, respectively. The IP not only participates in the hydration reaction but also plays an aggregate filling effect, significantly improving the mechanical properties of the IDMC. The pozzolanic effect is gradually enhanced with the increase of the DA content, and the hydration degree of the IDMC increases. The SC as an activator can moderately reduce the shrinkage rate of the IDMC. Based on the multi-index optimization analysis, the optimal mix proportion of the IDMC is obtained, which provides an effective reference for the preparation of the novel MC.
Advancing psoriasis drug delivery through topical liposomes
Authors: Kapoor Devesh U. , Garg Rahul , Maheshwari Rahul , Gaur Mansi , Sharma Deepak , Prajapati Bhupendra G. 
Published: July 2024

Abstract
Psoriasis, recognized as a chronic inflammatory skin disorder, disrupts immune system functionality. Global estimates by the World Psoriasis Day consortium indicate its impact on approximately 130 million people, constituting 4 to 5 percent of the worldwide population. Conventional drug delivery systems, mainly designed to alleviate psoriasis symptoms, fall short in achieving targeted action and optimal bioavailability due to inherent challenges such as the drug’s brief half-life, instability, and a deficiency in ensuring both safety and efficacy. Liposomes, employed in drug delivery systems, emerge as highly promising carriers for augmenting the therapeutic efficacy of topically applied drugs. These small unilamellar vesicles demonstrate enhanced penetration capabilities, facilitating drug delivery through the stratum corneum layer of skin. This comprehensive review article illuminates diverse facets of liposomes as a promising drug delivery system to treat psoriasis. Addressing various aspects such as formulation strategies, encapsulation techniques, and targeted delivery, the review underscores the potential of liposomes in enhancing the efficacy and specificity of psoriasis treatments.
La Beauté du Paysage est une Richesse nationale: limites à proteção à paisagem francesa no início do século XX.
Authors: Chacham Vera 
Published: July 2024

Em 1906 foi promulgada na França a primeira Lei de proteção especificamente voltada para os sítios e monumentos naturais de caráter artístico. Com esta lei, segundo LEBRUN (CORBIN, 2001), a França inaugura uma política da paisagem: a nova lei autorizava o “classement” –tombamento- dos sítios/paisagens pitorescos, o que colocava em questão o caráter absoluto do direito de propriedade. Embora a França não tenha sido pioneira em matéria de proteção de paisagens e sítios –assim como não o foi na pintura da paisagem- a lei foi de certa forma preparada, sobretudo, pela fundação, em 1901, da Société de protection des paysages de France. Nos textos do Boletim da Société, e na aplicação da lei de 1906 encontramos alguns subsídios para a discussão e reflexão sobre a proteção da paisagem no Brasil.
Um inventário das técnicas construtivas tradicionais brasileiras
Authors: Castriota Leonardo Barci , De Sousa Vilmar Pereira 
Published: July 2024

Este trabalho apresenta uma reflexão sobre o inventário das técnicas construtivas tradicionais brasileiras, realizada pelo Instituto do Patrimônio Histórico e Artístico Nacional (IPHAN) e pela Universidade Federal de Minas Gerais (UFMG), através do projeto Mestres Artífices, nos anos de 2010 e 2011. Trata-se de um trabalho interdisciplinar, que envolve os campos da Antropologia, Arquitetura e História, que trabalharam conjuntamente para aperfeiçoar a metodologia já estruturada pelo Inventário Nacional de Referências Culturais (INRC) daquele órgão.