bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does investigating an elevated C‐reactive protein detect infectious complications earlier after major colorectal surgery? A prospective clinical trial
Authors: Singh Primal (Parry) , Ganguly Timothy , Do Jee Eun , Murphy Elizabeth 
Published: June 2024

AbstractBackgroundC‐reactive protein (CRP) is a useful negative predictor of infectious complications following colorectal surgery. Whilst a CRP level below reported cut‐offs on postoperative day (POD) 3 to 5 can be reassuring, it can be difficult to interpret an elevated CRP above these cut‐offs. This study evaluated whether investigating an elevated CRP on POD 3–5 allows earlier detection of infectious complications.MethodsAdult patients undergoing elective colonic or rectal resection were prospectively evaluated over two consecutive time periods. Group 1 had CRP levels measured on POD 3–5 with routine clinical care while Group 2 followed an algorithm where CRP levels above certain cut‐offs (170 mg/L on POD3, 125 mg/L on POD4, or increase of 50 units from POD 3–4 or POD 4–5) led to an abdominopelvic CT scan and septic screen. Complications were graded as per the Clavien‐Dindo classification and Comprehensive Complication Index (CCI).Results120 patients were included in Group 1 and 60 patients were included in Group 2. There were no significant differences between the two groups with regards to patient, operation or disease characteristics. Whilst the overall complication burden was significantly greater in Group 2 (CCI 29.6 versus 12.2, P < 0.001), there were no significant differences between the groups in the day of diagnosis of infectious complication, the overall incidence, or type of complications.ConclusionEarly investigation of an elevated or increasing CRP on POD 3–5 following elective major colorectal surgery did not allow earlier detection of infectious complications.
Autonomic nervous system dysregulation in children with monosymptomatic nocturnal enuresis
Authors: Angeli Maria , Bitsori Maria , Schiza Sophia E. , Mamoulakis Charalampos , Mavridis Charalampos , Georgiadis Georgios , Tzatzarakis Manolis , Galanakis Emmanouil 
Published: June 2024

AbstractAimTo investigate the role of autonomic nervous system in subpopulations of children with enuresis.MethodsWe included 35 children with enuresis, divided in children with (17) and without nocturnal polyuria (18) and 43 healthy controls. For all participants hormones and neurotransmitters were measured. Patients and controls wore a sleep tracker device and children with enuresis underwent a 24 h blood pressure monitoring, nocturnal urine output measurement and uroflowmetry.ResultsChildren with enuresis had lower than controls copeptin and aldosterone, with the latter being more prominent in patients without nocturnal polyuria. Dopamine was lower in patients without nocturnal polyuria compared with patients with nocturnal polyuria. Children without polyuria experienced episodes only during NREM sleep, whereas in children with polyuria episodes occurred in both REM and NREM sleep. Children with enuresis experienced a non‐dipping phenomenon during sleep which was more prominent in the group without polyuria.ConclusionIn patients with nocturnal polyuria, nocturnal enuresis is associated with sympathetic hyperactivity which results in pressure polyuria and significantly lower systolic dipping during sleep. On the contrary, in children without nocturnal polyuria, it is mostly associated with bladder overactivity due to parasympathetic overstimulation as demonstrated by the NREM‐related enuretic episodes and the lower aldosterone and dopamine levels.
Examining the drivers of changes in mean earnings and earnings inequality in Indonesia
Authors: Wihardja Maria Monica , Pradana Abror Tegar 
Published: June 2024

AbstractThis article examines the main drivers behind changes in mean earnings and earnings inequality in Indonesia between 2001/2002 (data for 2001 and 2002 are combined) and 2018. During this period, there was an increase in workers' education level, average age, job quality and mean earnings. More women participated in the labor market, but women earn lower wages than men, therefore mean earnings fell. For the overall period, a decline in educational returns at all levels of education contributed negatively to earnings. Narrowing wage premia across provinces contributed to the increase in mean earnings. Indonesia's Gini index rose during this period, driven by the education distribution effect and the spatial location (place of residence) premium effect. Although improvement in education levels increased mean earnings, this was inequality‐increasing due to the “paradox of progress” (exponential wage returns to education). There is a need for complementary policies to attenuate the inequality‐increasing education and spatial location effects as well as gender wage gap.
Psychometric properties of the Child Anxiety and Depression Life Interference Scale – Young Adult version
Authors: Ienna Adrian F. , Sicouri Gemma , Peters Lorna , Hudson Jennifer L. 
Published: June 2024

AbstractObjectivesA life interference measure specifically designed for young adults with anxiety and depressive symptoms does not currently exist. This paper describes the development and psychometric evaluation of a brief self‐report measure of life interference associated with young adult anxiety and depression, the Child Anxiety and Depression Life Interference Scale – Young Adult version (CADLIS‐YA).DesignCross‐sectional, correlational and exploratory factor analysis (EFA).MethodsFive‐hundred and thirty‐two participants aged 18–24 years recruited from an undergraduate and community sample completed the CADLIS‐YA.ResultsAn EFA supported a three‐factor model describing the impact of young adult anxiety and depression on social life, family and daily life interference. Test–retest reliability and internal consistency were good to excellent. Convergent validity was demonstrated, and the scale differentiated between young adults with and without elevated anxiety and depressive symptoms. Support for divergent validity was limited.ConclusionsThe CADLIS‐YA is a reliable and valid life interference measure for young adults with symptoms of anxiety and depression. It is potentially suitable for administration in low‐resource research settings and it has promise for use in clinical settings; however, it needs validation in a clinical sample.
The relationship between the secondary vascular system and the lymphatic vascular system in fish
Authors: Panara Virginia , Varaliová Zuzana , Wilting Jörg , Koltowska Katarzyna , Jeltsch Michael 
Published: June 2024

ABSTRACTNew technologies have resulted in a better understanding of blood and lymphatic vascular heterogeneity at the cellular and molecular levels. However, we still need to learn more about the heterogeneity of the cardiovascular and lymphatic systems among different species at the anatomical and functional levels. Even the deceptively simple question of the functions of fish lymphatic vessels has yet to be conclusively answered. The most common interpretation assumes a similar dual setup of the vasculature in zebrafish and mammals: a cardiovascular circulatory system, and a lymphatic vascular system (LVS), in which the unidirectional flow is derived from surplus interstitial fluid and returned into the cardiovascular system. A competing interpretation questions the identity of the lymphatic vessels in fish as at least some of them receive their flow from arteries via specialised anastomoses, neither requiring an interstitial source for the lymphatic flow nor stipulating unidirectionality. In this alternative view, the ‘fish lymphatics’ are a specialised subcompartment of the cardiovascular system, called the secondary vascular system (SVS). Many of the contradictions found in the literature appear to stem from the fact that the SVS develops in part or completely from an embryonic LVS by transdifferentiation. Future research needs to establish the extent of embryonic transdifferentiation of lymphatics into SVS blood vessels. Similarly, more insight is needed into the molecular regulation of vascular development in fish. Most fish possess more than the five vascular endothelial growth factor (VEGF) genes and three VEGF receptor genes that we know from mice or humans, and the relative tolerance of fish to whole‐genome and gene duplications could underlie the evolutionary diversification of the vasculature. This review discusses the key elements of the fish lymphatics versus the SVS and attempts to draw a picture coherent with the existing data, including phylogenetic knowledge.
Single‐piece zirconia versus single‐piece titanium, narrow‐diameter dental implants in the anterior maxilla: 5‐year post‐loading results of a randomized clinical trial
Authors: Ruiz Henao Paula Andrea , Magrin Gabriel Leonardo , Caneiro‐Queija Leticia , Benfatti Cesar Augusto Magalhães , Leira Yago , Liñares‐González Antonio , Blanco‐Carrión Juan 
Published: June 2024

AbstractObjectivesThe aim of this study was to evaluate esthetic parameters in the anterior maxillary region by comparing single‐piece zirconia versus titanium narrow‐diameter implants. Additionally, clinical, radiological and patient‐reported outcome measures (PROMs) were analyzed.Materials and MethodsThirty implants (tissue level implant) were placed in 30 patients in the maxillary esthetic sector. Depending on randomization, a zirconia (test) or titanium implant (control) was placed. Esthetic, clinical, and radiological parameters, including the implant crown esthetic index (ICAI), pink esthetic score (PES), probing pocket depth, bleeding on probing, plaque index, and marginal bone levels, were evaluated at 12, 36 and 60 months after loading.ResultsSixty months after crown placement, no significant differences were found between groups. The ICAI values were 5.25 ± 4.21 and 4.50 ± 2.98 for the test and control groups, respectively. The corresponding PES values were 7.44 ± 1.93 and 7.43 ± 1.74 for the test and control groups, respectively. There were no significant intergroup differences for the rest of the parameters evaluated.ConclusionIt can be suggested that monotype zirconia implants may serve as a potential alternative to titanium implants in selected clinical scenarios. While the results demonstrated comparable esthetic, clinical, and radiological aspects for zirconia implants as compared to titanium implants after a 5‐year follow‐up period, further research with larger sample sizes and longer‐term follow‐up is recommended.
The Frequency of Health Anxiety, Coronavirus Anxiety and Anxiety Disorder in Patients With Tinnitus During the COVID‐19 Pandemic and the Impact of Pandemic on Tinnitus
Authors: Korkut Süleyman , Altıntaş Mustafa 
Published: June 2024

AbstractObjectivesThis study aimed to examine the frequency of anxiety disorder, coronavirus anxiety and health anxiety in tinnitus patients during the pandemic and also, determined the psychophysiological impact of COVID‐19 on tinnitus.MethodsThis cross‐sectional study was conducted in a tertiary central pandemic hospital from 15 July 2021 to 15 December 2022. In total, 124 patients with tinnitus and 77 healthy controls participated in the study. The sociodemographic data, a set of valid and reliable assessment instruments were used to measure outcomes of anxiety disorder, coronavirus anxiety, health anxiety and severity of tinnitus.ResultsPatients with tinnitus were found to experience higher levels of coronavirus anxiety, health anxiety and anxiety disorder than controls (p < 0.05). In tinnitus patients, the frequency of coronavirus anxiety was 22.6% and anxiety disorder was 18.5%. Notably, the levels of tinnitus severity were moderate to severe in more than half of the patients (51.6%) and also most of them (81.3%) reported that the severity of tinnitus during the pandemic was higher compared with the pre‐pandemic.ConclusionTinnitus patients had high levels of anxiety disorder, coronavirus anxiety and health anxiety. In line with these findings, it was evaluated that there was a relationship between the COVID‐19 pandemic with psychological problems and tinnitus. Therefore, the predominance of tinnitus symptoms at presentation should not lead the clinician to neglect the underlying psychopathological problems in these patients.
Aspects of glass and hybridization protocols for bonding of fiber posts to root dentine
Authors: Rauber Bárbara Facco , De Carli João Paulo , Dallepiane Felipe Gomes , Dogenski Letícia Copatti , Goedel Fábio , Cecchin Doglas , Palhano Huriel Scartazzini , Corazza Pedro Henrique , Collares Kauê Farias , Souza Matheus Albino , Farina Ana Paula 
Published: June 2024

AbstractThis study evaluated bond strength of glass fiber posts to root dentin using push‐out (PO) and diametral compression (DC), testing glycolic acid as a conditioner and varying dentin moisture. An additional aim was to test whether DC can be an alternative test to PO for bond strength assessment. Eighty bovine teeth were divided into eight groups (n = 10) defined by the use of either 37% glycolic acid or 37% phosphoric acid (PA) on moist or wet dentin before bonding with either Adapter SingleBond/RelyX ARC or One Step Plus/Duo‐Link Bisco. Each tooth provided discs with an internal diameter of 2 mm, external diameter of 5 mm, and height of 2 mm, which underwent PO and DC. Finite element analysis (FEA) was carried out on 3D models. When analyzing PO results through linear regression, the highest values of bond strength were observed using glycolic acid on wet dentin in the cervical and middle thirds of the teeth. Analyzing DC results, the only statistical influence on values was the dental thirds. The scatterplot of the DC results and the PO bond strength values indicated no relationship between the results of the two tests (r = 0.03; p = 0.64). PO test detected more sensitive changes in bond strength values than DC.
When birds of a feather flock together: Severe genomic erosion and the implications for genetic rescue in an endangered island passerine
Authors: Cavill Emily L. , Morales Hernán E. , Sun Xin , Westbury Michael V. , van Oosterhout Cock , Accouche Wilna , Zora Anna , Schulze Melissa J. , Shah Nirmal , Adam Pierre‐André , Brooke M. de L. , Sweet Paul , Gopalakrishnan Shyam , Gilbert M. Thomas P. 
Published: June 2024

AbstractThe Seychelles magpie‐robin's (SMR) five island populations exhibit some of the lowest recorded levels of genetic diversity among endangered birds, and high levels of inbreeding. These populations collapsed during the 20th century, and the species was listed as Critically Endangered in the IUCN Red List in 1994. An assisted translocation‐for‐recovery program initiated in the 1990s increased the number of mature individuals, resulting in its downlisting to Endangered in 2005. Here, we explore the temporal genomic erosion of the SMR based on a dataset of 201 re‐sequenced whole genomes that span the past ~150 years. Our sample set includes individuals that predate the bottleneck by up to 100 years, as well as individuals from contemporary populations established during the species recovery program. Despite the SMR's recent demographic recovery, our data reveal a marked increase in both the genetic load and realized load in the extant populations when compared to the historical samples. Conservation management may have reduced the intensity of selection by increasing juvenile survival and relaxing intraspecific competition between individuals, resulting in the accumulation of loss‐of‐function mutations (i.e. severely deleterious variants) in the rapidly recovering population. In addition, we found a 3‐fold decrease in genetic diversity between temporal samples. While the low genetic diversity in modern populations may limit the species' adaptability to future environmental changes, future conservation efforts (including IUCN assessments) may also need to assess the threats posed by their high genetic load. Our computer simulations highlight the value of translocations for genetic rescue and show how this could halt genomic erosion in threatened species such as the SMR.
Reflections on the opportunities and challenges of applying experience‐based co‐design (EBCD) to phase 1 clinical trials in oncology
Authors: Graber Nils , Canova Nina , Bryant‐Lukosius Denise , Robert Glenn , Navarro‐Rodrigo Blanca , Trueb Lionel , Coukos George , Eicher Manuela , Corbière Tourane , Colomer‐Lahiguera Sara 
Published: June 2024

AbstractBackgroundExperience‐Based Co‐Design (EBCD) is a multi‐stage participatory action research process which was developed originally to increase patient involvement in service improvement initiatives. This viewpoint article serves as a reflection on the researchers' experiences, focusing on the application and feasibility of participatory approaches, particularly co‐design, in the specific context of early‐phase clinical trials.MethodsWe reflect on the opportunities and challenges of applying EBCD in a new context of early‐phase clinical trials in oncology where experimental treatments are increasingly perceived as a therapeutic option and, in certain instances, their efficacy may lead to accelerated approval facilitating a swifter integration into standard care.ResultsWe propose that the opportunity of applying EBCD in such trials lies in improving the delivery of person‐centered care, care coordination, and support during the transition from experimental to standard care. Three potential challenges when applying EBCD in early‐phase clinical trials are discussed related to: the need for standardization in trial processes; planning EBCD in a context of high uncertainty; and vulnerability of patient populations.ConclusionIntegrating EBCD into early‐phase oncology trials presents an opportunity to enhance person‐centered care and can lead to simultaneous improvements in care processes and therapeutic development.Patient or Public ContributionThis article has been developed with the collaboration of a patient partner who serves on the advisory board of our ongoing EBCD study in early clinical trials.
Setting up the endoscopy room for benign prostatic hypertrophy treatment: Nursing expertise relevance
Authors: Corso Luca Dal , Gilioli Veronica , Boldini Michele , Bianchi Alberto , Brusa Davide , Rubilotta Emanuele , Antonelli Alessandro 
Published: June 2024

AbstractIn recent decades, nursing has been integrated into increasingly advanced and complex healthcare settings. One of the environments in which the level of preparation and expertise required of nurses is most adaptable is the operating room, where the variety of surgical approaches and the use of sometimes complex equipment at times requires a long learning curve. One of the specialties most affected in this regard is urology, with several techniques having emerged in recent years, particularly in the field of endoscopic treatment of benign prostatic hyperplasia (BPH). Understanding how the expertise of the surgical nurse may be influenced by the learning of new surgical procedures allows us to grasp how different the learning curve may differ between experienced and less experienced nurses in dealing with new surgical approaches. A total of 36 patients diagnosed with BPH and eligible for endoscopic treatments were enrolled (9 candidates for TURP, 9 for Holmium laser enucleation of the prostate (HoLEP), 9 for REZUM water vapour therapy, and 9 for UROLIFT). The nursing expertise was divided into three levels: novice (endoscopic room experience <6 months), competent (>1 year and 6 months of experience), and expert (experience >6 years). Objectively measurable data were collected regarding the instrumentation required to perform procedures, the setup time of the operating room and surgical devices, and the transition time between procedures in the same operating room. Surgical nurses were also asked to provide subjective commentary on the perceived difficulty in dealing with the four types of procedures. Regarding the learning curve of the surgical nurse, minimally invasive procedures were found to be more accessible to less experienced nurses. In particular, REZUM showed the most significant impact on reducing skill assimilation time. The impact of experience gained was notable for the endoscopic approaches of TURP and HoLEP: experienced surgical nurses were faster in acquiring new skills and setting up the materials needed for the surgical procedure. Considering nursing staff expertise and learning needs in the urologic endoscopy operating room is necessary and desirable because it allows easier and faster learning of new surgical approaches, especially in more complex techniques. Relying on experienced nursing staff is also desirable because it has an impact on overall operating time.
Escape from education fever?: Impact of migration on child education practice
Authors: Jung Yong Moon 
Published: June 2024

AbstractAn extraordinary interest in education has a historical and cultural foundation in Korea, but its harmful nature has created education emigration of Korean parents. This study sought to track if and how the culturally embedded education fever changed over migration generations. To this end, this study compared three different parent groups: staying‐put parents in the origin country (Korean parents in Korea), first‐generation migrant parents (Korean–Australian parents with no school‐age education in Australia) and next‐generation migrant parents (Korean–Australian parents who were born or fully educated in Australia). Continuity and discontinuity in child education practice in the context of migration were explored and the education fever was seen to be persistent as part of a strategy for social inclusion. Despite a high level of aspiration for academic success of children, migrant parents were seen to take an acculturated or modified form of parenting with a recognition of diversified paths of success.
Factors influencing the job embeddedness of new graduate nurses: A multicentre cross‐sectional study
Authors: Song Ziling , Yao Xin , Wang Jing , Shen Yuanyuan , Zhang Peihua , Huang Xiaoqiong 
Published: June 2024

AbstractAimTo identify factors associated with job embeddedness from the perspective of retaining new graduate nurses.DesignThe study was cross‐sectional in design.MethodsConvenience and stratified sampling were used to recruit 415 newly graduated nurses from 12 tertiary hospitals in China. Anonymized data were collected through self‐designed sociodemographic questionnaires, job embeddedness scale, feedback‐seeking behaviour scale, authentic leadership perception scale and decent work scale. Appropriate indicators were used for descriptive statistics and t‐tests, ANOVA, Pearson correlation analysis and multiple linear regression to examine the influencing factors.ResultsThe study showed that monthly income level, decent labour, authentic leadership and feedback‐seeking behaviour were significant predictors of job embeddedness among new graduate nurses.ConclusionThe job embeddedness of new graduate nurses is moderate. Nursing managers need to construct reasonable and fair compensation incentives, adopt positive leadership styles and encourage proactive feedback‐seeking behaviours to improve the job embeddedness of new graduate nurses and alleviate the nursing talent shortage.ImpactExploring the factors influencing the job embeddedness of new graduate nurses provides a reference for establishing new graduate nurse retention strategies to help promote the career development of new graduate nurses and alleviate the nursing brain drain.Reporting MethodWe adhered to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines.Patient or Public ContributionNo patient or public contribution.