bluuebunny/crossref_metadata_2025_split huggingface dataset:
Psychometric Properties of Health-Related Quality of Life Instruments in Patients Undergoing Palmar Fasciectomy for Dupuytren's Disease: A Prospective Study
Authors: Thoma Achilleas , Kaur Manraj Nirmal , Ignacy Teegan Aili , Levis Carolyn , Martin Stuart , Duku Eric , Haines Ted 
Published: January 2014

Background The traditional outcome measured following treatment of Dupuytren's Disease (DD) has been digital range of motion; specifically the gain in digital extension. The outcomes research movement in the last three decades however has been advocating the measurement of outcomes from the patient's perspective using Health-Related Quality of Life questionnaires (HRQOL). Although several generic and region-specific HRQOL questionnaires exist, there is no guidance as to which one is the most appropriate for this population. The objective of this study is to evaluate the psychometric properties of three self-reported HRQOL outcome measures in patients with DD. Methods Patients with DD were enrolled from the practices of three plastic surgeons. Test-retest reliability, concurrent validity and responsiveness of three HRQOL questionnaires were compared in a prospective study design. The HRQOL measures included Health Utilities Index Mark 3 (HUI3), Short Form-36 (SF-36), and the Michigan Hand Questionnaire (MHQ). Results All three measures demonstrated good test-retest reliability (ICC=0.77–0.85). Concurrent validity was found between the HUI3 pain and dexterity attributes and SF-36 physical summary score. The sensitivity of the MHQ to detect changes in the status of the patient was found to be high (effect size=1.14) whereas that of the SF-36 was trivial. Conclusions The HUI3 and the MHQ seem to be reliable and valid tools to assess the HRQOL in patients with Dupuytren's Disease.
Performance of Spanish‐speaking community‐dwelling elders in the United States on the Uniform Data Set
Authors: Benson Gloria , de Felipe Jesús , Xiaodong  , Sano Mary 
Published: January 2014

AbstractBackgroundSpanish is the second‐most common language spoken in the United States, and Spanish speakers represent one third of the aging population. The National Alzheimer's Coordinating Center's Uniform Data Set implemented a Spanish neuropsychological battery. Previous work described the neuropsychological performance for English speakers. Here we describe performance on the Spanish version.MethodsData from 276 Spanish speakers with normal cognition were summarized, with descriptive tables of performance on individual cognitive tests. Regression techniques were used to evaluate the effect of demographics on cognitive performance.ResultsSpanish speakers were younger (70.0 vs 74.0 years) and less educated (10.7 vs 15.7 years) with more females (76% vs 63% female) than the previously described English speakers. Higher education and lower age were associated with better performance.ConclusionThis national cohort of well‐characterized Spanish‐speaking elders provides descriptive data on cognitive performance, an important tool for clinical and research efforts.
Who's Afraid of Determinism?
Authors: Stevenson Leslie 
Published: January 2014

AbstractBecause of the idealizations involved in the ideas of a total state of the world and of all the laws of nature, the thesis of all-encompassing determinism is unverifiable. Our everyday non-scientific talk of causation does not imply determinism; nor is it needed for the Kantian argument for a general causal framework as a condition for experience of an objective world. Determinism is at best a regulative ideal for science, something to be approached but never reached.
Beyond simple utility in predicting self-control fatigue: A proximate alternative to the opportunity cost model
Authors: Inzlicht Michael , Schmeichel Brandon J. 
Published: January 2014

AbstractThe opportunity cost model offers an ultimate explanation of ego depletion that helps to move the field beyond biologically improbable resource accounts. The model's more proximate explanation, however, falls short of accounting for much data and is based on an outdated view of human rationality. We suggest that our own process model offers a better proximate account of self-control fatigue.
Revisiting “the Long Night” of Iranian Workers: Labor Activism in the Iranian Oil Industry in the 1960s
Authors: Jefroudi Maral 
Published: January 2014

AbstractThis article reviews the labor historiography of Iran for the period between the 1953 coup and the early revolutionary activism of late the 1970s, an interlude marked by a lack of histories of labor activism. Based on a qualitative analysis of the types of collective actions that oil workers engaged in during the period, this article argues that contextualizing the struggles of workers and the types of collective actions they engaged in will tell us more about the social and political changes that they experienced and participated in than the search for an ideal type of labor activism. It is argued that the social and political climate of Iran during the 1960s, characterized by political repression and an extensive centralized reform program, added new tactics to workers’ repertoires of action as they made use of the discourse of the regime for their own ends. This study is based on archival research at the International Institute of Social History archives in Amsterdam, the BP archives at Coventry, the National Archives of UK in London, and the National Archives and Records Administration in Washington, DC.
Assessment of malaria incidence using the Richards model in Arunachal Pradesh, India
Authors: SRINIVASA RAO M. , SURYANARYANA MURTY U. , MADHUSUDHAN RAO K. , KARTIK N. , PREEYANTEE G. , BALAKRISHNA N. 
Published: January 2014

SUMMARYMonitoring of malaria intensity in terrain regions of Arunachal Pradesh, India is very difficult as the dynamics of mosquito populations varies to a large extent due to altitude and frequent changes in climatic conditions. There is a scarcity of information on the influence of climatic factors on malaria morbidity in Arunachal Pradesh. Hence, a pilot study was conducted from 2006 to 2010 to understand malaria transmission dynamics, seasonal distribution and disease morbidity. Plasmodium vivax and P. falciparum are the two major parasites for malaria transmission in Arunachal Pradesh. Out of 142 558 malaria cases analysed from 2006 to 2010, P. vivax infection contributed 72·1% followed by P. falciparum (27·9%). However, the overall morbidity of malaria declined from 37/1000 in 2006 to 18/1000 population in 2010. From this study it was observed that the temporal distribution of malaria cases varied between districts and high morbidity rates were reported mostly during the wet season. To understand malaria transmission dynamics in the study area, the Richards model was used to predict malaria cases. The output of the results from this model predicted a higher number of malaria cases (K) during 2006 and a gradual decline in subsequent years. Similarly, the growth rate r, and exponential deviation α, were almost identical for all the years, which shows that the Richards model is the most suitable model for the prediction of malaria cases.
Molecular cloning, gene expression and functional expression of a phosphoenolpyruvate carboxylaseOsppc1in developing rice seeds: implication of involvement in nitrogen accumulation
Authors: Yamamoto Naoki , Kubota Tatsuya , Masumura Takehiro , Shiraishi Naomasa , Tanaka Kunisuke , Sugimoto Toshio , Oji Yoshikiyo 
Published: January 2014

AbstractWe isolated two cDNAs of phosphoenolpyruvate carboxylase (PEPC) from developing rice seeds,Osppc1andOsppc3. The deduced amino acid sequences of both cDNAs share several conserved motifs with other non-photosynthetic PEPCases, and these common motifs are known to be functionally important to their regulatory properties. The deduced protein sequence ofOsppc1was clustered into a monocotyledonous plant-specific clade, andOsppc3was clustered into a gramineous plant-specific clade in the phylogenetic tree of plant PEPCases. The mRNA accumulations ofOsppc1andOsppc3were found in developing rice seeds throughout the grain-filling stages, although their expression patterns differed:Osppc1was strongly expressed at 7 d after flowering, andOsppc3was strongly expressed at 4 d after flowering. The kinetic properties of the Osppc1 recombinant protein were quite similar to those of maize root-type PEPCase, except that the sensitivity for malate at pH 7.3 was weaker. Mining rice microarray data, we observed thatOsppc1was co-expressed with aspartate aminotransferase and alanine aminotransferase, which are involved in seed nitrogen metabolism. Moreover, reannotation of the co-expressed genes revealed thatOsppc1, the two aminotransferases and the enolase were mapped on to the consecutive reaction from 2-phosphoglycerate to glutamate and pyruvate in the cytosol. These results imply thatOsppc1functions cooperatively with the two aminotransferases in the synthesis of amino acids that are used for storage protein synthesis in developing rice seeds.
Microstructure of Bentonite in Iron Ore Green Pellets
Authors: Bhuiyan Iftekhar U. , Mouzon Johanne , Schröppel Birgit , Kaech Andres , Dobryden Illia , Forsmo Seija P.E. , Hedlund Jonas 
Published: January 2014

AbstractSodium-activated calcium bentonite is used as a binder in iron ore pellets and is known to increase strength of both wet and dry iron ore green pellets. In this article, the microstructure of bentonite in magnetite pellets is revealed for the first time using scanning electron microscopy. The microstructure of bentonite in wet and dry iron ore pellets, as well as in distilled water, was imaged by various imaging techniques (e.g., imaging at low voltage with monochromatic and decelerated beam or low loss backscattered electrons) and cryogenic methods (i.e., high pressure freezing and plunge freezing in liquid ethane). In wet iron ore green pellets, clay tactoids (stacks of parallel primary clay platelets) were very well dispersed and formed a voluminous network occupying the space available between mineral particles. When the pellet was dried, bentonite was drawn to the contact points between the particles and formed solid bridges, which impart strength to the solid compact.
Genome-wide DNA methylation analysis of human brain tissue from schizophrenia patients
Authors: Wockner L F , Noble E P , Lawford B R , Young R McD , Morris C P , Whitehall V L J , Voisey J 
Published: January 2014

AbstractRecent studies suggest that genetic and environmental factors do not account for all the schizophrenia risk, and epigenetics also has a role in disease susceptibility. DNA methylation is a heritable epigenetic modification that can regulate gene expression. Genome-wide DNA methylation analysis was performed on post-mortem human brain tissue from 24 patients with schizophrenia and 24 unaffected controls. DNA methylation was assessed at over 485 000 CpG sites using the Illumina Infinium HumanMethylation450 Bead Chip. After adjusting for age and post-mortem interval, 4641 probes corresponding to 2929 unique genes were found to be differentially methylated. Of those genes, 1291 were located in a CpG island and 817 were in a promoter region. These includeNOS1,AKT1,DTNBP1,DNMT1,PPP3CCandSOX10, which have previously been associated with schizophrenia. More than 100 of these genes overlap with a previous DNA methylation study of peripheral blood from schizophrenia patients in which 27 000 CpG sites were analysed. Unsupervised clustering analysis of the top 3000 most variable probes revealed two distinct groups with significantly more people with schizophrenia in cluster one compared with controls (P=1.74 × 10−4). The first cluster composed of 88% of patients with schizophrenia and only 12% controls, whereas the second cluster composed of 27% of patients with schizophrenia and 73% controls. These results strongly suggest that differential DNA methylation is important in schizophrenia etiology and add support for the use of DNA methylation profiles as a future prognostic indicator of schizophrenia.
Perturbation of neuronal cobalamin transport by lysosomal enzyme inhibition
Authors: Zhao Hua , Ruberu Kalani , Li Hongyun , Garner Brett 
Published: January 2014

Cbl (cobalamin) utilization as an enzyme cofactor is dependent on its efficient transit through lysosomes to the cytosol and mitochondria. We have previously proposed that pathophysiological perturbations in lysosomal function may inhibit intracellular Cbl transport with consequences for down-stream metabolic pathways. In the current study, we used both HT1080 fibroblasts and SH-SY5Y neurons to assess the impact that protease inhibitors, chloroquine and leupeptin (N-acetyl-L-leucyl-L-leucyl-L-argininal), have on the distribution of [57Co]Cbl in lysosomes, mitochondria and cytosol. Under standard cell culture conditions the distribution of [57Co]Cbl in both neurons and fibroblasts was ~5% in lysosomes, 14% in mitochondria and 81% in cytosol. Treatment of cells with either 25 μM chloroquine or 40 μM leupeptin for 48 h significantly increased the lysosomal [57Co]Cbl levels, by 4-fold in fibroblasts and 10-fold in neurons, and this was associated with reduced cytosolic and mitochondrial [57Co]Cbl concentrations. Based on Western blotting of LAMP2 in fractions recovered from an OptiPrep density gradient, lysosomal Cbl trapping was associated with an expansion of the lysosomal compartment and an increase in a subpopulation of lysosomes with increased size and density. Moreover, the decreased mitochondrial Cbl that was associated with lysosomal Cbl trapping was correlated with decreased incorporation of [14C] propionate into cellular proteins/macromolecules, indicating an inhibition of Cbl-dependent Mm-CoA (methylmalonyl-coenzyme A) mutase activity. These results add support to the idea that lysosomal dysfunction may significantly impact upon Cbl transport and utilization.
Isolated discontinuous energy pump‐source inverters
Authors: Dehghan Seyed Mohammad , Seifi Ebrahim , Mohamadian Mustafa , Rajaei Amir Hossein , Amiri Arash 
Published: January 2014

Recently, several single‐stage buck–boost inverters, such as Z‐source inverter (ZSI), Luo‐source inverter and Cuk‐source inverter, have been developed. These inverters are considered as discontinuous energy pump‐source inverters (DEPSI), since these inverters benefit from a pump circuit with discontinuous output voltage as front‐end stage. Considering the concept, this study adds two new converters (Zeta and Forward‐source inverters) to this family and compares DEPSIs (including already investigated and the presented inverters) and two‐stage converters using DC/DC converter as the boost stage regarding several criteria: 1 – boost capability, 2 – cost, 3 – efficiency and 4 – passive components requirement. The results are discussed to determine the appropriate topology according to different voltage gains. Also, a new control algorithm called minimum constant boost control for optimum control of Luo, Cuk and Zeta source inverters has been proposed here, which is used in the analysis and comparison. Experimental tests for a 250 W prototype of the converters are performed, which confirm the simulations and theoretical results.
Carrier transport properties of Be-doped InAs/InAsSb type-II infrared superlattices
Authors: Steenbergen E. H. , Elhamri S. , Mitchel W. C. , Mou Shin , Brown G. J. 
Published: January 2014

The InAs/InAsSb type-II superlattice materials studied to date for infrared detector applications have been residually n-type, but p-type absorber regions with minority carrier electrons can result in increased photodiode quantum efficiency, RoA, and detectivity. Therefore, Be-doped InAs/InAsSb superlattices were investigated to determine the p-type InAs/InAsSb superlattice material transport properties essential to developing high quality photodiode absorber materials. Hall measurements performed at 10 K revealed that the superlattice converted to p-type with Be-doping of 3 × 1016 cm−3 and the hole mobility reached 24 400 cm2/Vs. Photoresponse measurements at 10 K confirmed the 175 meV bandgap and material optical quality.
Network of mutually repressive metastasis regulators can promote cell heterogeneity and metastatic transitions
Authors: Lee Jiyoung , Lee Jinho , Farquhar Kevin S. , Yun Jieun , Frankenberger Casey A. , Bevilacqua Elena , Yeung Kam , Kim Eun-Jin , Balázsi Gábor , Rosner Marsha Rich 
Published: January 2014

Significance
Cancer progression, as an evolutionary process, should accelerate if higher cellular variability is present. However, the sources of nongenetic variability in metastatic progression are largely unknown. To address this question, we characterized a transcriptional regulatory network for the metastasis suppressor Raf kinase inhibitory protein (RKIP). We previously showed that the transcription factor BACH1 is negatively regulated by RKIP and promotes breast cancer metastasis. Here we reveal a network architecture between the metastasis suppressor RKIP and the metastasis promoter BACH1 that enables single cells to generate a stable subpopulation of prometastatic cells without any genetic changes.
QCGWAS: A flexible R package for automated quality control of genome-wide association results
Authors: van der Most Peter J. , Vaez Ahmad , Prins Bram P. , Munoz M. Loretto , Snieder Harold , Alizadeh Behrooz Z. , Nolte Ilja M. 
Published: January 2014

Abstract
Summary: QCGWAS is an R package that automates the quality control of genome-wide association result files. Its main purpose is to facilitate the quality control of a large number of such files before meta-analysis. Alternatively, it can be used by individual cohorts to check their own result files. QCGWAS is flexible and has a wide range of options, allowing rapid generation of high-quality input files for meta-analysis of genome-wide association studies.
Availability: http://cran.r-project.org/web/packages/QCGWAS
Contact: i.m.nolte@umcg.nl
Supplementary information: Supplementary data are available at Bioinformatics online.
Identification of histone 3 variant 2 interacting factors
Authors: Latreille Daniel , Bluy Lisa , Benkirane Monsef , Kiernan Rosemary E. 
Published: January 2014

Abstract
The epigenome is defined as a type of information that can be transmitted independently of the DNA sequence, at the chromatin level, through post-translational modifications present on histone tails. Recent advances in the identification of histone 3 variants suggest a new model of information transmission through deposition of specific histone variants. To date, several non-centromeric histone 3 variants have been identified in mammals. Despite protein sequence similarity, specific deposition complexes have been characterized for both histone 3.1 (H3.1) and histone 3.3 (H3.3), whereas no deposition complex for histone 3.2 (H3.2) has been identified to date. Here, we identified human H3.2 partners by immunopurification of nuclear H3.2 complexes followed by mass spectrometry analysis. Further biochemical analyses highlighted two major complexes associated with H3.2, one containing chromatin associated factor-1 subunits and the other consisting of a subcomplex of mini chromosome maintenance helicases, together with Asf1. The purified complexes could associate with a DNA template in vitro.
The Carbon/Nitrogen Regulator ARABIDOPSIS TOXICOS EN LEVADURA31 Controls Papilla Formation in Response to Powdery Mildew Fungi Penetration by Interacting with SYNTAXIN OF PLANTS121 in Arabidopsis
Authors: Maekawa Shugo , Inada Noriko , Yasuda Shigetaka , Fukao Yoichiro , Fujiwara Masayuki , Sato Takeo , Yamaguchi Junji 
Published: January 2014

Abstract
The carbon/nitrogen (C/N) balance of plants is not only required for growth and development but also plays an important role in basal immunity. However, the mechanisms that link C/N regulation and basal immunity are poorly understood. We previously demonstrated that the Arabidopsis (Arabidopsis thaliana) Arabidopsis Tóxicos en Levadura31 (ATL31) ubiquitin ligase, a regulator of the C/N response, positively regulates the defense response against bacterial pathogens. In this study, we identified the plasma membrane-localized soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor SYNTAXIN OF PLANTS121 (SYP121) as a novel ATL31 interactor. The syp121-1 loss-of-function mutant showed similar hypersensitivity to C/N stress conditions as the atl31 atl6 double mutant. SYP121 is essential for resistance to penetration by powdery mildew fungus and positively regulates the formation of cell wall appositions (papillae) at fungal entry sites. Microscopic analysis demonstrated that ATL31 was specifically localized around papillae. In addition, ATL31 overexpressors showed accelerated papilla formation, enhancing their resistance to penetration by powdery mildew fungus. Together, these data indicate that ATL31 plays an important role in connecting the C/N response with basal immunity by promoting papilla formation through its association with SYP121.
Determining the core activities in the order fulfillment process: an empirical application
Authors: F. Espino-Rodríguez Tomas , Rodríguez-Díaz Manuel 
Published: January 2014

Purpose– This work examines the relationship between internal and relational capabilities and the creation of value to the end consumer in the case of the process of receipt, manufacture, and delivery of orders within the supply chain. This work develops a methodology to identify operations that generate core competences and those that do not, with the aim of improving the management of the supply chain.Design/methodology/approach– This work analyses the order fulfillment process in a representative sample of firms operating in a region of Spain. To accomplish the research objectives, a personal survey was conducted using a questionnaire to evaluate 13 activities of the order distribution process in the supply chain.Findings– The results of the study reveal that internal and relational capabilities explain the creation of value to the consumer. They also identify two groups of operations in line with their ability to be sources of relational or internal competitive advantage. With regard to the activities, it was shown that there are some activities that form part of the core competences, while others constitute non-core competences. This work demonstrates that the core activities generate higher value to the end consumer; however, it also shows how important the non-core activities may be to the creation of value.Practical implications– The work offers orientation as to how the analyzed process should be redesigned to obtain a competitive advantage. Thus, this higher value to the end consumer will enable the firm to reduce prices or at least maintain them, in which case the firm will be able to offer additional services that differentiate it from the competition.Originality/value– Finally, although the literature contains some works that analyze capabilities or relational performance, none to date have used variables such as activity simplification, integration and relational competitiveness in the framework of relational capabilities in the order fulfillment process. Another significant innovation of this work is the analysis at operation level, in which 13 activities belonging to an important process in the supply chain are analyzed.