bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Infiltrative Margins in Glioblastoma: Important Is What Has Been Left behind
Authors: Karschnia Philipp , Tonn Joerg-Christian , Cahill Daniel P. 
Published: August 2024

Summary
Supramaximal resection beyond the contrast-enhancing tumor borders represents an emerging surgical strategy for patients with newly diagnosed glioblastoma. A recent study provides evidence detailing the interactive effects of more aggressive surgery on other clinical predictors of outcome, supporting guidance for surgical decision-making and informing clinical trialists about the need to stratify for extent of resection.
See related article by Park et al., p. 4866
Desigualdades raciais para além do paradigma
Authors: França Danilo 
Published: August 2024

The so-called “paradigm of racial inequalities”, inaugurated by Carlos Hasenbalg, answered decisive questions about the permanence of disparities between blacks and whites in Brazil and guided new agendas, research designs and forms of analysis of racial inequalities. This article builds some critical notes on the way in which racial inequalities are thematized based on this paradigm, especially the focus on the market as a sphere of observation, and points out the potential for retaking this research object by the contemporary sociology of racial relations, renewed by perspective of intersectionalities and the emergence of new themes.
“Defendendo a paz social”: entre a naturalização e o racismo em decisões de decretação de prisão preventiva.
Authors: Marques Luiz Henrique Gamboa , Lourenço Luiz Cláudio 
Published: August 2024

This study aimed to analyze the arguments mobilized by judges to justify the issuance of preventive detention orders and to observe the existence of a relationship between these arguments and class and race factors. The methodology used was the documentary analysis of interlocutory decisions converting flagrant arrests into preventive detentions, referring to charges of theft and robbery that occurred between 2015 and 2018 in the metropolitan region of Salvador, Brazil. A total of 322 interlocutory decisions to decree preventive detention were analyzed, retrieved from the case files of Salvador Prison/BA, a unit for temporary detainees. At the end of the research, it was concluded that, among the justifications in force in Article 312 of the Code of Criminal Procedure, 100% of the decisions analyzed were based on the category of guaranteeing public order, understood as social harmony offended by the dangerousness of the prisoner. This dangerousness is expressed by the concepts of criminal recidivism and modus operandi. It was also concluded that these arguments reproduce class and race stereotypes, since they use mechanisms to naturalize the group most affected by the net of the criminal justice system (young black men), depriving them of the enjoyment of citizenship and protection of fundamental rights.
Pré-Cálculo: Um Curso Preparatório Para Ingressantes da ESALQ/USP
Authors: Souza Carolina Rodrigues , Zilio Jéssica Carolina , Oliveira Allison Queiroz de , Savian Taciana Villela , Silva Marcelo Andrade da 
Published: August 2024

Cálculo é uma disciplina fundamental para diversos cursos de nível superior, uma vez que promove a construção de um raciocínio lógico e matemático essencial para a resolução de problemas práticos e tomadas de decisão. Apesar da sua importância, uma parcela considerável dos alunos não obtém máximo aproveitamento das aulas, devido sobretudo à falta de conhecimento prévio em Matemática e à dificuldade em assimilar conceitos abstratos. A preocupação com relação ao mau desempenho dos graduandos na disciplina de Cálculo vai além da questão curricular, uma vez que o déficit de aprendizagem desses conceitos pode impactar no rendimento de disciplinas posteriores e até na vida profissional dos indivíduos. Diante desse impasse, foi criado em 2018 o Curso Pré-Cálculo, oferecido pelo Departamento de Ciências Exatas aos alunos ingressantes da ESALQ/USP. Este trabalho descreve o surgimento do curso, seu formato atual e os principais resultados obtidos ao longo do seu oferecimento. O curso passou por melhorias a cada nova edição, incluindo uma reestruturação da carga horária e a criação de uma apostila, baseada na demanda dos participantes. Graças ao empenho e dedicação dos professores e alunos da pós-graduação, tem sido observado nas últimas edições uma evolução positiva com relação à aprovação dos alunos na disciplina de Cálculo, bem como na avaliação do curso pelos próprios participantes.
Tissue-Based Predictors of Impaired Right Ventricular Strain in Coronary Artery Disease: A Multicenter Stress Perfusion Study
Authors: Villar-Calle Pablo , Kochav Jonathan D. , Vadaketh Krista , Chiu Caitlin , Tak Katherine , Agoglia Hannah , Liberman Nicole , Nguyen Kenny L. , Vizcarra-Tellez Abdier , Wu Alan , RoyChoudhury Arindam , Khalique Omar K. , Judd Robert M. , Kim Raymond J. , Shah Dipan J. , Heitner John F. , Farzaneh-Far Afshin , Shenoy Chetan , Owyang Clark G. , Mukherjee Monica , Horn Evelyn M. , Weinsaft Jonathan W. , Kim Jiwon 
Published: August 2024

BACKGROUND:
Right ventricular (RV) dysfunction is known to impact prognosis, but its determinants in coronary artery disease are poorly understood. Stress cardiac magnetic resonance (CMR) has been used to assess ischemia and infarction in relation to the left ventricle (LV); the impact of myocardial tissue properties on RV function is unknown.

METHODS:

Vasodilator stress CMR was performed in patients with known coronary artery disease at 7 sites between May 2005 and October 2018. Myocardial infarction was identified on late gadolinium enhancement-CMR, and infarct transmurality was graded on a per-segment basis. Ischemia was assessed on stress CMR based on first-pass perfusion and localized by using segment partitions corresponding to cine and late gadolinium enhancement analyses. RV function was evaluated by CMR-feature tracking for primary analysis with a global longitudinal strain threshold of 20% used to define impaired RV strain (RV
IS
); secondary functional analysis via RV ejection fraction was also performed.

RESULTS:

A total of 2604 patients were studied, among whom RV
IS
was present in 461 patients (18%). The presence and magnitude of RV
IS
were strongly associated with LV dysfunction, irrespective of whether measured by LV ejection fraction or wall motion score (
P
<0.001 for all). Regarding tissue substrate, regions of ischemic and dysfunctional myocardium (ie, hibernating myocardium) and infarct size were each independently associated with RV
IS
(both
P
<0.001). During follow-up (median, 4.62 [interquartile range, 2.15–7.67] years), 555 deaths (21%) occurred. Kaplan-Meier analysis for patients stratified by presence and magnitude of RV dysfunction by global longitudinal strain and RV ejection fraction each demonstrated strong prognostic utility for all-cause mortality (
P
<0.001). RV
IS
conferred increased mortality risk (hazard ratio, 1.35 [95% CI, 1.11–1.66];
P
=0.003) even after controlling for LV function, infarction, and ischemia.

CONCLUSIONS:

RV
IS
in patients with known coronary artery disease is associated with potentially reversible LV processes, including LV functional impairment due to ischemic and predominantly viable myocardium, which confers increased mortality risk independent of LV function and tissue substrate.
Hypertensive Disorders of Pregnancy and Brain Health in Midlife: The CARDIA Study
Authors: Jiang Xiaqing , Schreiner Pamela J. , Gunderson Erica P. , Yaffe Kristine 
Published: August 2024

BACKGROUND:
To understand the role of hypertensive disorders of pregnancy (HDP), including preeclampsia and gestational hypertension (GH), in brain health earlier in life, we investigated the association of HDP with midlife cognition and brain health.

METHODS:
We studied a prospective cohort of women, baseline age 18 to 30 years, who were assessed at study years 25 and 30 with a cognitive battery and a subset with brain magnetic resonance imaging. A history of HDP was defined based on self-report. We conducted linear regression to assess the association of a history of preeclampsia, GH, or no HDP with cognition and brain magnetic resonance imaging white matter hyperintensities.

RESULTS:

Among 1441 women (mean age, 55.2±3.6 years), 202 reported preeclampsia and 112 reported GH. GH was associated with worse cognitive performance: global cognition (mean score, 23.2 versus 24.0;
P
=0.018), processing speed (67.5 versus 71.3;
P
=0.01), verbal fluency (29.5 versus 31.1;
P
=0.033), and a trend for executive function (24.3 versus 22.6;
P
=0.09), after multivariable adjustment. GH was associated with a greater 5-year decline in processing speed (mean change, −4.9 versus −2.7;
P
=0.049) and executive function (−1.7 versus 0.3;
P
=0.047); preeclampsia was associated with a greater 5-year decline on delayed verbal memory (−0.3 versus 0.1;
P
=0.041). GH and preeclampsia were associated with greater white matter hyperintensities in the parietal and frontal lobes, respectively.

CONCLUSIONS:
GH and preeclampsia are associated with cognition and white matter hyperintensities during midlife, with differences in cognitive domains and brain lobes. Women with HDP may need to be closely monitored for adverse brain outcomes starting in midlife.
Do the New Brazilian Agreements on Cooperation and Facilitation of Investment Promote Outward Foreign Direct Investment?
Authors: Bellak Christian , Leibrecht Markus 
Published: August 2024

Abstract
Brazil has recently adopted a novel approach in investment protection, the Agreements on Cooperation and Facilitation of Investment (ACFIs) which aim inter alia at promoting Brazil’s rising outward FDI. Motivated by claims that ACFIs will not achieve this goal – while otherwise tying the hands of policy makers – we use data over the years 2001 to 2022 and apply a Synthetic Control approach to study whether outward Foreign Direct Investment Stock of Brazil in Mexico is spurred by the ratification of the Mexico–Brazil ACFI. The concerns about ACFIs cannot be dismissed as our evidence shows that the ACFI does not promote outward foreign direct investment (FDI), at least for the post-treatment years used in our analysis. The absence of an impact is most likely driven by the omission of substantive provisions and, most notably, of Investor-State Dispute Settlement, which would address the hold-up problem in international investment.
Use of rice by-products for production of the Tenebrio molitor larvae: emphasis on the fatty acid profile
Authors: Chamorro D.P. , Dias K.C. , Oliveira L.F.S. , Cordeiro M.W.S. , Wagner R. , Kuradomi R.Y. , Pedron F.A. , Ferrigolo F.R.G. , Pretto A. , Lanes C.F.C. 
Published: August 2024

Abstract
The objectives of this study were to assess the ability of Tenebrio molitor larvae to biotransform by-products from rice processing enriched with 1% flaxseed oil into high-nutritional value food and to obtain oil from T. molitor larvae with a fatty acid profile suitable for future application in animal nutrition. Larvae of T. molitor were cultured on seven experimental diets, including four diets composed of rice processing by-products enriched with 1% flaxseed oil (rice husk, rice cleaning residue, whole rice bran, and defatted rice bran), and three control diets (chicken feed, wheat bran in combination with yeast (in a 9:1 ratio) with the addition of 1% flaxseed oil, and wheat bran in combination with yeast (in a 9:1 ratio) without flaxseed oil). The addition of 1% flaxseed oil aimed to improve the larvae’s fatty acid profile. Growth and larval survival were assessed during the experimental period. The larvae were analyzed for dry matter, ash, protein, fat levels, and fatty acid profiles. Larvae fed diets containing wheat bran with oil (111.9 ± 5.2 mg) and wheat bran without oil (111.6 ± 1.9 mg) exhibited significantly higher final weights than the rest of the dietary treatments, followed by larvae fed diets composed of rice cleaning residue (75.8 ± 2.2 mg) and chicken feed (67.8 ± 7.0 mg). The remaining treatments showed significantly lower weights. Survival rates were similar among treatments, being equal to or greater than 90%. Protein content ranged from 39.3% to 49.1%, while lipid levels varied from 23.3% to 39.4%. The fatty acid profile differed significantly among treatments. Linoleic acid (C18:2n-6) was the predominant polyunsaturated fatty acid (PUFA), with the highest concentration observed in larvae fed chicken feed. Higher levels of polyunsaturated fatty acids (PUFAs) were found in larvae raised on whole rice bran. The highest omega-6 content was found in the larvae reared with chicken feed (24.1%), while the highest omega-3 content was found in the treatment with whole rice bran (6.1%). The omega-6/omega-3 ratio varied significantly among the treatments, reaching 42.9 in the treatment with rice cleaning residue, while in the whole rice bran treatment, the ratio was 3.5. Moreover, in wheat bran treatments, the addition of 1% flaxseed oil reduced the omega 6/omega-3 ratio from 29.1 to 8.9. The growth results of the current study demonstrate that among the tested rice by-products, the best outcomes were obtained with rice cleaning residue. However, the most favorable fatty acid profile for future application in animal nutrition was achieved with whole rice bran enriched with 1% flaxseed oil.
Tech Competency and the Pink pc: Illuminating the iMac G3 and pc Builds
Authors: Harkin Stephanie 
Published: August 2024

Abstract
Where women were once historically at the forefront of computer programming, contemporary tech culture erases their participation. Today, however, tech-competency is showcased as feminine in online Pink pc build videos, which contest dominant narratives that place tech culture adjacent to geek masculinity. Before young people were building their own Pink pc’s, Apple’s G3 series represented an earlier articulation of feminine computer design. Apple’s rounded, colourful personal computer became an unconventional marker of femininity. Pink pc s challenge technology’s prevalent masculine-coding. Their hyperfeminine designs reflect possible agentic identity expression and resistance to hegemonic masculine taste values. Yet, the Pink pc also surfaces in corporate and post-feminist contexts and cultures, typically restricted by economic mobility. This article explores these contradictions through the Pink pc, from Apple’s G3 to Pink pc builds today, developing understandings towards feminist science and technology studies, invisible gaming cultures, and Critical Femininities.
Development of a Two-Step EOF Statistical Postprocessing Algorithm to Identify Patterns of Systematic Error and Variance within GEFSv12 Reforecasts
Authors: Stikeleather William D. , Roundy Paul E. 
Published: August 2024

Abstract
Analysis of seasonally varying signals of model error biases, as well as the diagnosis of space–time patterns of synoptic error, here is accomplished through the development of a statistical postprocessing algorithm based on time-extended empirical orthogonal functions (EEOFs) built on patterns of variance. This work analyzes GEFSv12 200-hPa geopotential height (Z200) model error against ERA5 reanalysis data. The mean-square error variance between GEFSv12 reforecast and ERA5 grows rapidly after day 7 of a forecast and continues to increase through the end of the 16-day forecast period. At lead time 16, the largest variance occurs in mid- to high-latitude oceanic storm tracks. Variance is highest during hemispheric winter when baroclinic energy is abundant. The seasonal cycle of error shows largest anomalies in the high latitudes during hemispheric winter. After running the titular two-step, space–time EEOF algorithm, a standardized spatial eigenspectrum shows that eigenvalues increase at longer lead times after decreasing in the medium range, demonstrating that the algorithm extracts large-scale signals of systematic error in the long range. Leading wintertime space–time eigenmode pairs include high-latitude blocking structures and Rossby wave trains. Results suggest that the large-scale systematic errors in GEFSv12 Z200 initiate in part from inaccurate representations of phase speeds of atmospheric waves in the polar jet.
Determining if Admission Thromboelastography can Predict the Development of Late Resolving Multiple Organ Failure in Trauma Patients
Authors: Smith Ross P. , Dwyer Lauren K. , O’Dell Jacob C. , McCoy Christopher C. , Guidry Christopher A. , Winfield Robert A. 
Published: August 2024

Background Normal coagulation TEG values on admission negatively correlate with overall risk of multiple organ failure, but less is known about association between coagulation and late-resolving multiple organ failure (LRMOF) risk. Here, the relationship between TEG parameters and development of LRMOF was investigated. Methods We conducted a retrospective assessment of patients at high postinjury multiple organ failure risk at our center. The primary outcome was LRMOF. Results Analysis included 742 patients. Demographics were 76% male, mean age of 41, mean ISS of 23, 34% hypercoagulability, and 16% developed LRMOF. Patients with normal admission TEG developed LRMOF at significantly lower unadjusted rates than patients with coagulation disturbances (9 vs 16%-19%, P = 0.029); however, multivariable logistic regression demonstrated that neither coagulation profile nor individual admission TEG parameters showed association with LRMOF. Conclusions In this series, we found no significant relationship between coagulation status and LRMOF development.
Systematic Literature Review of the Presentation and Management of Pediatric Relapsing Polychondritis
Authors: Montero Mackenzie L. , Panda Roshan M. , Palacios Victoria J. , Solis Roberto N. , Levi Jessica R. 
Published: August 2024

Introduction: Pediatric Relapsing Polychondritis (RP) is a rare autoimmune disorder that causes inflammation and damage to cartilage in children. Common symptoms include pain, swelling and deformities in the ears, nose, trachea, joints, and eyes. The lack of research on the pediatric population necessitates further evaluation of the literature on pediatric RP to summarize existing patterns in presentation, management, and treatment. Methods: A systematic review was conducted on PubMed and Embase from 1947 to April 2023 on RP in patients under 21 years old abiding by the 2020 PRISMA checklist. Only patient presentations meeting McAdam criteria for RP and including information on management were included. Results: From the 304 initial studies, 54 studies were included for final analysis with a total of 68 patients, who were predominantly female (65%). With a median diagnostic delay of 1 year, the mean age of onset was 12 years old. The most common symptoms on presentation included bilateral auricular chondritis (69%), nasal cartilage inflammation (62%), and respiratory tract chondritis (63%). The most commonly reported information in the literature for the initial workup usually included CT/MRI (72%), bronchoscopy (57%), biopsy (51%), and labs (88%), which most commonly displayed elevated ESR (59%). The most common medications were corticosteroids (91%) and methotrexate (35%) and the most common procedural treatment was tracheostomy (38%). The most efficacious treatment options were monoclonal antibodies (87%, n = 15) and corticosteroids (66%, n = 62) used in 22% and 91% of patients, respectively. The most commonly used monoclonal antibody therapy was infliximab (13%, n = 9). Conclusion: The most common presentation for pediatric RP includes chondritis of the ear, nose, and respiratory tract. The most effective treatment options include corticosteroids and monoclonal antibody therapy, such as infliximab. Our findings highlight increasing remission achieved with anti-rheumatic drugs and monoclonal antibody treatment, especially alongside corticosteroids.
Research on airfoil surface flow structure testing based on Tuft velocity measurement method
Authors: Du Hai , Gui Hongping , Li Gang , Qiao Peng , Jiang Hao , Yang Zhangyi , Qi Bin 
Published: August 2024

Fluorescent tuft visualization technology, as a practical and convenient technique, has attracted widespread attention. In this study, a novel fluorescent tuft velocity measurement method is developed based on existing technologies. This method involves the recognition of tuft deflection angles, image transformation, block processing, temporal averaging, and post-visualization processing. Additionally, quantitative measurement of flow field velocity is achieved through tuft calibration. The study begins by comparing tufts of different materials, examining both fluorescent and deflection characteristics to determine optimal tuft parameters. The impact of tuft length on deflection characteristics is also investigated. Finally, the cotton tuft with a length of 7 mm and a diameter of about 0.1 mm was obtained as the best tuft sought in this experiment. Subsequently, at Reynolds number Re = 1.7 × 105, airfoil surface flow field visualization and quantitative analysis are conducted, exploring the relationship between airfoil surface flow structure and aerodynamics at different angles of attack. Finally, a comparative study is conducted between tuft velocity results and oil flow visualization experiments, as well as particle image velocimetry experiments, confirming the feasibility of the fluorescent tuft velocity measurement method.
Study of electrocardiographic corrected QT interval and QT dispersion abnormalities, erythrocyte sedimentation rate, serum uric acid in patients with systemic lupus erythematosus
Authors: Vijaykumar Shinde Vikrant , G Gopikrishna , Nandi Dhruva , Kumar JS 
Published: August 2024

Introduction Systemic Lupus Erythematosus (SLE) is an autoimmune disease having a variety of clinical symptoms because of multiple organs being affected at once or progressively over time. Cardiovascular system (CVS) involvement is the third most frequent cause of death in SLE, among other factors. The prognosis can be determined by looking at QT interval measurements, which have shown an elevated risk of mortality from cardiovascular causes. Methods A case-control study was conducted on 80 patients (40 SLE patients and 40 controls) for a duration of 16 months. SLE patients and controls were identified from the general medicine and rheumatology outpatient department (OPD) based on the inclusion criteria. A thorough clinical examination was performed after obtaining a detailed clinical history. Baseline blood tests were then performed on the SLE patients and ECG was taken from both cases and controls. The serum uric acid level was measured using an automated analyzer, and the ESR was computed using Westergren’s Method. The corrected QT interval (QTc) was estimated using Bazett’s method. All the collected data were compared and analyzed using IBM SPSS Statistics version 23.0. Results The majority of age distribution among SLE patients and controls was 21–25 years (37.5%) (Mean - 15.7 ± 14.9 years). Duration of SLE was predominantly reported between 1 and 12 months (62.5%). Very high (40%) and high (40%) lupus disease activity was recorded in the majority as per the SELENA-SLEDAI score. There was a significant difference between QTc values among SLE patients and controls (t- 8.117) ( p-.0005). Upon correlating SLEDAI with the QTc, QTd, ESR, and Uric acid parameters among the SLE patients, ESR parameters were found to be moderately correlated (r-0.460) with the SLEDAI which was statistically significant ( p- .003). Conclusion QTc interval and ESR values can be a simple and potential method for early detection of cardiac involvement in SLE patients with active disease activity. This will not only facilitate early diagnosis of disease activity, but it will also provide an affordable and accessible avenue for low and middle-income countries to decrease the SLE burden.