bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personalized presentation builder for persuasive communication
Authors: Khataei Amirsam , Arya Ali 
Published: June 2015

Presentations are effective ways of communicating information, especially in the field of education, but they might not be equally or fully beneficial and persuasive to all users. Each member of the audience might be interested in a particular topic, come from a different background and profession, and have his or her own personality traits.
In this conceptual paper, we first describe our persuasive personalization model; the Individualization Pyramid based on Yale Attitude Change Approach. The model consists of the following main sections: selecting contents by applying segmentation, adjusting comprehensibility of the text, tailoring the language of the text to fit with user's personality and recommending content that is associated with user's personal history within the related subjects. We then propose an enhanced version of our previously published presentation builder, which uses users' digital traces such as those on social media to personalize presentation content. Finally, we highlight the available tools and algorithms to assist us with developing the system.
Ying Zhang
Authors: Zimmermann Roger , Kankanhalli Mohan , Brown Michael , Tsang Ooi Wei , Zhang Ying 
Published: June 2015

In recent years, we have witnessed an overwhelming number of user-generated videos being captured on a daily basis. An essential reason is the rapid development in camera technology and hence videos are easily recorded on multiple portable devices, especially mobile smartphones. Such flexibility encourages the modern videos to be tagged with additional various sensor properties. In this thesis, we are interested in geo-referenced videos whose metadata is closely tied to geographic identifications. These videos have great appeal for prospective travelers and visitors who are unfamiliar with a region, an area or a city. For example, before someone visits a place, a georeferenced video search engine can quickly retrieve a list of videos that are captured in this place so the visitors could obtain an overall visual impression, conveniently and quickly. However, users face the prospect of an ever increasing viewing burden if the size of these video repositories keeps increasing and as a result more videos are relevant to a search query. To manage these video retrievals and provide viewers with an efficient way to browse, we introduce a novel solution to automatically generate a summarization from multiple user generated videos and present their salience to viewers in an enjoyable manner.
In this thesis, we investigate how to formulate, display and improve a multi-video summarization with the following contributions. The first three works propose solutions to detect video salience among multiple videos according to their geographic properties and convert the summarization to a graph-analysis problem with a dynamic programming-based solution to achieve the optimized informativeness, quality and coherency. The fourth work proposes an interactive and dynamic video exploration system where people can conduct personalized summary queries through direct map-based manipulations. Lastly, we investigate whether external crowdsourcing databases contribute to improving the summary quality by recommending a list of photography spots which are of potential to capture appealing photos for a landmark.
Modulation of Glucocorticoid Resistance in Pediatric T-cell Acute Lymphoblastic Leukemia by Increasing BIM Expression with the PI3K/mTOR Inhibitor BEZ235
Authors: Hall Connor P. , Reynolds C. Patrick , Kang Min H. 
Published: June 2015

AbstractPurpose: The aim of our study is to evaluate the preclinical therapeutic activity and mechanism of action of BEZ235, a dual PI3K/mTOR inhibitor, in combination with dexamethasone in acute lymphoblastic leukemia (ALL).Experimental Design: The cytotoxic effects of BEZ235 and dexamethasone as single agents and in combination were assessed in a panel of ALL cell lines and xenograft models. The underlying mechanism of BEZ235 and dexamethasone was evaluated using immunoblotting, TaqMan RT-PCR, siRNA, immunohistochemistry, and immunoprecipitation.Results: Inhibition of the PI3K/AKT/mTOR pathway with the dual PI3K/mTOR inhibitor BEZ235 enhanced dexamethasone-induced anti-leukemic activity in in vitro (continuous cell lines and primary ALL cultures) and systemic in vivo models of T-ALL (including a patient-derived xenograft). Through inhibition of AKT1, BEZ235 was able to alleviate AKT1-mediated suppression of dexamethasone-induced apoptotic pathways leading to increased expression of the proapoptotic BCL-2 protein BIM. Downregulation of MCL-1 by BEZ235 further contributed to the modulation of dexamethasone resistance by increasing the amount of BIM available to induce apoptosis, especially in PTEN-null T-ALL where inhibition of AKT only partially overcame AKT-induced BIM suppression.Conclusions: Our data support the further investigation of agents targeting the PI3K/mTOR pathway to modulate glucocorticoid resistance in T-ALL. Clin Cancer Res; 22(3); 621–32. ©2015 AACR.
Synthetic Lethal Approaches Exploiting DNA Damage in Aggressive Myeloma
Authors: Cottini Francesca , Hideshima Teru , Suzuki Rikio , Tai Yu-Tzu , Bianchini Giampaolo , Richardson Paul G. , Anderson Kenneth C. , Tonon Giovanni 
Published: June 2015

Abstract
Ongoing DNA damage is a common feature of epithelial cancers. Here, we show that tumor cells derived from multiple myeloma, a disease of clonal plasma cells, demonstrate DNA-replicative stress, leading to DNA damage. We identified a poor-prognosis subset of multiple myeloma with extensive chromosomal instability and replicative stress, which rely on ATR to compensate for DNA-replicative stress; conversely, silencing of ATR or treatment with a specific ATR inhibitor triggers multiple myeloma cell apoptosis. We show that oncogenes, such as MYC, induce DNA damage in multiple myeloma cells not only by increased replicative stress, but also via increased oxidative stress, and that reactive oxygen species–inducer piperlongumine triggers further DNA damage and apoptosis. Importantly, ATR inhibition combined with piperlongumine triggers synergistic multiple myeloma cytotoxicity. This synthetic lethal approach, enhancing oxidative stress while concomitantly blocking replicative stress response, provides a novel combination targeted therapy to address an unmet medical need in this subset of multiple myeloma.
Significance: Multiple myeloma remains an incurable disease. We have identified a subset of multiple myeloma patients with poor prognosis, whose tumors present chromosomal instability, replicative and oxidative stress, and DNA damage. We define a synthetic lethal approach enhancing oxidative stress while targeting replicative stress response, inducing tumor cell apoptosis in this patient subset. Cancer Discov; 5(9); 972–87. ©2015 AACR.
This article is highlighted in the In This Issue feature, p. 893
Phonetic and Visual Cues to Questionhood in French Conversation
Authors: Torreira Francisco , Valtersson Emma 
Published: June 2015

AbstractWe investigate the extent to which French polar questions and continuation statements, two types of utterances with similar morphosyntactic and intonational forms but different pragmatic functions, can be distinguished in conversational data based on phonetic and visual bodily information. We show that the two utterance types can be distinguished well over chance level by automatic classification models including several phonetic and visual cues. We also show that a considerable amount of relevant phonetic and visual information is present before the last portion of the utterances, potentially assisting early speech act recognition by addressees. These findings indicate that bottom-up phonetic and visual cues may play an important role during the production and recognition of speech acts alongside top-down contextual information.
Impact of Freezing Time and Balloon Size on the Thermodynamics and Isolation Efficacy During Pulmonary Vein Isolation Using the Second Generation Cryoballoon
Authors: Takami Mitsuru , Lehmann H. Immo , Misiri Juna , Parker Kay D. , Sarmiento Ray I. , Johnson Susan B. , Packer Douglas L. 
Published: June 2015

Background—
The differences in ablation characteristics of freezing time and balloon size using second generation cryoballoon are still unknown.

Methods and Results—

Twenty-six dogs underwent pulmonary vein (PV) isolation. Balloon and tissue temperatures (left atrial–PV junction, phrenic nerve, and internal esophagus) were monitored. The ablation duration was randomized to either 3 or 4 minutes, which did not show significant differences in temperature profiles, PV isolation success rate, complications, or histological changes. Twenty dogs underwent cryoablation using 28-mm cryoballoon, 6 dogs were done using the 23-mm cryoballoon. Positioning of the 23-mm cryoballoon was more distal in the PV, which resulted in better PV occlusion. Temperature profiles showed lower temperatures in the 23-mm cryoballoon than in the 28-mm cryoballoon (inner balloon, median [range]: −51.5 [−66.0 to −31.0] versus −43.0 [−64.0 to −26.0]°C,
P
<0.001; balloon surface: −43.0 [−60.0 to −15.8] versus −6.5 [−46.2 to 28.9]°C,
P
<0.001; left atrial–PV junction: −6.7 [−20.0 to 21.4] versus 15.8 [−14.4 to 35.1]°C,
P
<0.001), and trended toward a higher PV isolation success rate in the 23-mm cryoballoon. Histologically, deeper extensions of ablative lesions into the PV were seen with 23-mm cryoballoon, and larger ablative lesions were seen in the left atrial antrum using 28-mm cryoballoon.

Conclusions—
The efficacy of 3-minute ablation was not significantly different from 4-minute ablation in dogs. The 23-mm cryoballoon had a greater cooling effect than the 28-mm cryoballoon for small PVs, but showed narrower ablative lesions in the left atrial antrum.
Personal recovery in personality disorder: Systematic review and meta-synthesis of qualitative methods studies
Authors: Shepherd Andrew , Sanders Caroline , Doyle Michael , Shaw Jenny 
Published: June 2015

Background and aims: Support of personal recovery represents the aim for many modern mental health services. There is a lack of conceptual clarity around the application of the term however and this is particularly problematic with regard to the personality disorder diagnoses. This study sought to review the existing qualitative methods literature in relation to the experience of personal recovery in personality disorder. Methods: A systematic literature search was conducted. Identified studies were incorporated through meta-synthesis in order to develop higher order descriptive themes representative of the individual experience described within included studies. Results: Three studies were identified and incorporated into the meta-synthesis. Three novel higher order themes were developed: Safety and containment as a prerequisite to recovery, social networks and autonomy in the recovery process and identity construction as a process of change. Conclusion: Personal recovery in personality disorder is revealed as a complex process reflecting both personal and social experiences or desires. These findings have important implications for clinical practice – emphasising the need to work closely with individuals and to develop an understanding of both their social experience and networks. Further research, taking greater account of social context in the recovery process, is necessary.
Effect of inter-segmental air exchanges on local and overall clothing ventilation
Authors: Ismail Nagham , Ghaddar Nesreen , Ghali Kamel 
Published: June 2015

The aim of this work is to study the effect of the connection between arm and trunk segments in changing the flow characteristics and local ventilation. A model is developed that solves coupled momentum, mass and heat balances, including buoyancy for the connected clothed upper human body. The model was validated by performing computational fluid dynamics simulations to compare the microclimate air flow characteristics and flow direction at the connections. In addition, the model was also validated by comparing predicted overall ventilation with published data. The interconnection air exchanges affected significantly local ventilation in the trunk segment and the direction of the flow in the open-aperture-clothed arm segment. It was found that at relatively high wind speed ( Vw ≥ 0.9 m/s) and with a permeable jacket, the inter-segmental ventilation became important and exceeded 5 l/min. Meanwhile, this inter-segmental ventilation caused an increase of 15% of trunk ventilation and a reduction of 4% of arm ventilation. The inter-segmental ventilation vanished and the air exchange between the trunk and the arm was no longer important at low permeability ( α = 0.05 m/s) and at low wind speed ( Vw = 0.1 m/s). Finally, the inter-segmental ventilation was more important for the open clothed arm aperture compared to when it was closed.
Unmasking the surgeons: the evidence base behind the use of facemasks in surgery
Authors: Da Zhou Charlie , Sivathondan Pamela , Handa Ashok 
Published: June 2015

The use of surgical facemasks is ubiquitous in surgical practice. Facemasks have long been thought to confer protection to the patient from wound infection and contamination from the operating surgeon and other members of the surgical staff. More recently, protection of the theatre staff from patient-derived blood/bodily fluid splashes has also been offered as a reason for their continued use. In light of current NHS budget constraints and cost-cutting strategies, we examined the evidence base behind the use of surgical facemasks. Examination of the literature revealed much of the published work on the matter to be quite dated and often studies had poorly elucidated methodologies. As a result, we recommend caution in extrapolating their findings to contemporary surgical practice. However, overall there is a lack of substantial evidence to support claims that facemasks protect either patient or surgeon from infectious contamination. More rigorous contemporary research is needed to make a definitive comment on the effectiveness of surgical facemasks.
National Institute for Clinical Excellence: NICE works
Authors: Rawlins Michael D 
Published: June 2015

Summary The National Institute for Clinical Excellence was established in 1999. Its original remit was to undertake technology appraisals of (mainly) new interventions and to develop clinical guidelines. In providing both forms of guidance, it was required to take into account both clinical and cost effectiveness. After a difficult first few months, it gained the confidence and trust of the professions. It subsequently gained additional responsibilities with a commensurate increase in its staffing and budget. It is, moreover, the only one of the National Health Service organisations established in the late 1990s and early 2000s to have not only survived but grown. This paper describes not only the National Institute for Clinical Excellence’s early years but also, in the author’s view, the features of its guidance programmes that led to its success and (in retrospect) some things it could have done differently.
Agricultural Trade and Markets in British India
Authors: Sheel Alok 
Published: June 2015

The study draws upon both unpublished as well as published sources to describe the structure of, and changes in, agricultural trade and markets at the regional and local level in the British India districts of Shahabad and Gaya, spanning parts of the current state of Bihar, in northern India during 1800–1920.  Agricultural trade and markets during the period under study were largely shaped by the logic of subsistence agriculture, available infrastructure, the land rent payment system and patterns of demand. There were six striking developments. First, the construction of all-weather roads and the railway, part of the modern public infrastructure put in place soon after the administration of the two districts came directly under the British Crown in 1858, gave a great fillip to trading activity. Old trade routes lost their pre-eminence, as new channels took root. The modern infrastructure also tended to integrate the markets in the two districts on the one hand, while increasing the pulls of external markets on the other. This was reflected in greater price equalisation between markets. Second, notwithstanding greater market integration and increased stability in annual farm yields on account of the construction of modern irrigation canals that reduced the reliance on monsoonal precipitation, sharp seasonal fluctuations in the market price of food grains continued. Third, there was a sustained secular upswing in agricultural prices practically throughout the period, with the terms of trade moving in favour of agriculture, as the entry of mass produced wage goods into local markets had a deflationary impact on industrial goods. This, along with the growing depth of trade and markets, and changes in the land rent payment system, facilitated the rise of a new social group that became a new source of demand and was to subsequently play a major role in the emerging political economy. Fourth, there were three inter-dependent tiers of trading activity—long-distance trade conducted by arhatiyas, trade between major trade centres conducted by ladu beparis and trade within the village dominated by the grihasta bepari, the chief source of agricultural credit and frequently an agriculturist himself. Modern infrastructure transformed the conduct of long-distance trade, even as the pattern of short-distance trade and credit remained remarkably resilient. The fifth feature was the sharp and sudden expansion of the range of products traded in the market, as the latter was drawn into the emerging global system with the first industrial nation at the epicentre. While locally produced handicraft products like indigenous cotton cloth and paper lost their former importance, trade in agricultural commodities and imported industrial goods grew. Sixth, and last, was the increase in the monetisation of the rural economy at the cutting edge as the traditional system of paying rent in kind was commuted to cash.
National Breast Cancer Screening Programme, Singapore: Evaluation of participation and performance indicators
Authors: Loy En Yun , Molinar Darko , Chow Khuan Yew , Fock Christine 
Published: June 2015

Objective To evaluate participation rates and performance indicators in the National Breast Cancer Screening Programme, BreastScreen Singapore (BSS). Methods Data on women aged 40-69 screened in the period 2002-2009 was obtained from BSS and from the Singapore Cancer Registry. Participation rates and performance indicators (including screen detection rates, small tumour detection rates, recall rates, accuracy and interval cancer rates) were examined. Results BSS participation rate has remained above 10% since 2005. Based on health surveys, national mammography rates have increased from 29.7% before BSS to 39.6% in 2010 after BSS. Performance indicators, with the exception of recall rates, specificity, and interval cancer rate (for first screen), generally improved from 2002-2006 to 2007-2009 and are comparable with organized breast screening programmes in other developed countries. Conclusion BSS breast cancer screening coverage and rescreen rates in Singapore could be improved. Mechanisms to monitor recall rates are in place, and training opportunities are provided to aid the professional development of radiologists.
Identification of Biomarkers Associated With Alzheimer’s Disease by Bioinformatics Analysis
Authors: Zhao Yanxin , Tan Wei , Sheng Wenhua , Li Xiaohong 
Published: June 2015

Background: This study aimed to explore the biomarkers of Alzheimer’s disease (AD). Methods: The microarray data of GSE16759 were from the expression profile samples of 4 parietal lobe tissues from patients with AD and 4 ones from age-matched control participants. The differentially expressed micro RNAs (miRNAs) and genes (DEGs) underwent hierarchical clustering and function analysis followed by target genes prediction. Finally, DEGs were mapped to the target genes to construct miRNA-regulated networks. Results: A total of 427 DEGs were obtained and clustered into 5 functions. After DEGs were mapped to the predicted target genes, 313 regulatory pairs were established. The target genes SEC22 vesicle trafficking protein homolog B ( SEC22B) and SEC63 homolog ( SEC63) regulated by miRNA-206, RAB10, member RAS oncogene family ( RAB10) regulated by miRNA-655, and fms-related tyrosine kinase 1 ( FLT1) regulated by miRNA-30e-3p and miRNA-369-3p were involved in the biological processes of protein transport and regulation of cell motion. Conclusion: The target genes SEC22B, RAB10, and FLT1 may be potential biomarkers of AD.
Morphologic predictors of aortic expansion in chronic type B aortic dissection
Authors: Kotelis D , Grebe G , Kraus P , Müller-Eschner M , Bischoff M , von Tengg-Kobligk H , Böckler D 
Published: June 2015

Aim To identify morphologic factors affecting aortic expansion in patients with uncomplicated type B aortic dissections. Methods Computed tomography data of 24 patients (18 male; median age: 61 years), diagnosed with acute uncomplicated type B aortic dissections between 2002 and 2013, were retrospectively reviewed. All patients had at least two computed tomography angiography scans and six months of uneventful follow-up. Computed tomography scans were assessed by two independent readers with regard to presence and number of entry tears. Thoracic and abdominal aortic diameters were derived using image processing software. Results Twenty-two of 24 patients showed aortic expansion over a median computed tomography angiographic follow-up of 33.2 months. Annual rates showed an increase of 1.7 mm for total aortic diameter, 2.1 mm for the false and a decrease of −0.4 mm for the true lumen. In three patients (12.5%), aortic diameter exceeded 60 mm during follow-up, and all three patients underwent thoracic endovascular aortic repair. Patients with a maximum aortic diameter <4 cm at baseline showed a significantly higher expansion rate compared to cases with an initial maximum aortic diameter of ≥4 cm ( p=0.0471). A median of two entries (range: 1–5) was recognized per patient. Presence of more than two entry tears ( n = 13) was associated with faster overall diameter expansion (mean annual rates: 2.18 mm vs. 1.16 mm; p = 0.4556), and decrease of the cross-sectional surface of the true lumen over time (annual rate for > 2 entries vs. ≤2 entries: −7.8 mm2 vs. +37.5 mm2; p = 0.0369). Median size of entry tears was 12 mm (range: 2–53 mm). Conclusions The results presented herein suggest that uncomplicated type B aortic dissection patients with more than two entry tears and/or an initial maximum aortic diameter of<4 cm are at risk for aortic dilatation and, therefore, may require stricter follow-up including the possible need for early intervention.