bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non‐suicidal self‐injury in high school students: Associations with identity processes and statuses
Authors: Luyckx Koen , Gandhi Amarendra , Bijttebier Patricia , Claes Laurence 
Published: March 2015

ABSTRACTNon‐suicidal self‐injury (NSSI) refers to the direct, deliberate destruction of one's body tissue without suicidal intent. Research has highlighted the importance of identity synthesis versus confusion for NSSI. However, the association with identity processes and statuses remains unknown. A total of 568 adolescents reported on NSSI, identity, anxiety, and depression. Although identity processes of identification with commitment (negatively) and ruminative exploration (positively) were related to NSSI variables, these relationships were no longer significant when controlling for anxiety and depression. When examining identity statuses (using cluster analysis), individuals who had engaged in NSSI in the past (but not currently) were more likely to be in the moratorium cluster and less likely to be in the achievement cluster. Individuals who were currently engaging in NSSI were more likely to be in the troubled diffusion cluster. Clinicians should be attentive to the complex interplay between identity and NSSI when treating adolescents.
Special Needs Population: Care of the Geriatric Patient Population in the Perioperative Setting
Authors: Oster Kristen A. , Oster Cynthia A. 
Published: March 2015

AbstractThe geriatric population, defined as people 65 years of age and older, undergoing surgical procedures is a vulnerable population. Age, once considered a contraindication for a surgical procedure, is no longer a constraint for individuals requiring surgical intervention. However, older adult patients are at increased risk for developing a variety of complications. This article reviews age‐related physiological changes and discusses the special needs of the geriatric population across the perioperative continuum of care.
Clinical Issues—April 2015
Authors: Ogg Mary J. 
Published: March 2015

This MonthMonitoring patients receiving local anesthesiaKey words: local anesthesia, nurse monitoring, staffing, assessment, acuity.Safe use of single‐ and multi‐dose medication vialsKey words: beyond‐use date, BUD, multi‐dose medication vials, medication expiration dates.Use of positive airway pressure respirators (PAPRs) in the ORKey words: positive airway pressure respirators, PAPRs, surgical mask, N95, surgical N95, droplet precautions, airborne precautions.
Conservative Management of Invasive Placenta Using Combined Prophylactic Internal Iliac Artery Balloon Occlusion and Immediate Postoperative Uterine Artery Embolization
Authors: D'Souza Donna L. , Kingdom John C. , Amsalem Hagai , Beecroft John R. , Windrim Rory C. , Kachura John R. 
Published: March 2015

Purpose The objective of the study was to evaluate the efficacy and safety of combined prophylactic intraoperative internal iliac artery balloon occlusion and postoperative uterine artery embolization in the conservative management (uterine preservation) of women with invasive placenta undergoing scheduled caesarean delivery. Methods Ten women (mean age 35 years) with invasive placenta choosing caesarean delivery without hysterectomy had preoperative insertion of internal iliac artery occlusion balloons, intraoperative inflation of the balloons, and immediate postoperative uterine artery embolization with absorbable gelatin sponge. A retrospective review was performed with institutional review board approval. Outcome measures were intraoperative blood loss, transfusion requirement, hysterectomy rate, endovascular complications, surgical complications, and postoperative morbidity. Results All women had placenta increta or percreta, and concomitant complete placenta previa. Mean gestational age at delivery was 36 weeks. In 6 women the placenta was left undisturbed in the uterus, 2 had partial removal of the placenta, and 2 had piecemeal removal of the whole placenta. Mean estimated blood loss during caesarean delivery was 1.2 L. Only 2 patients (20%) required blood transfusion. There were no intraoperative surgical complications, endovascular complications, maternal deaths, or perinatal deaths. Three women developed postpartum complications necessitating postpartum hysterectomy; the hysterectomy rate was therefore 30% and uterine preservation was successful in 70%. Conclusion Combined bilateral internal iliac artery balloon occlusion and uterine artery embolization may be an effective strategy to control intraoperative blood loss and preserve the uterus in patients with invasive placenta undergoing caesarean delivery.
Expression of vascular endothelial growth factor (VEGF) mRNA, VEGF receptor 2 (Flk‐1) mRNA, and of VEGF co‐receptor neuropilin (Nrp)‐1 mRNA in brain tissue of aging Tg2576 mice by in situ hybridization
Authors: Muche Abebe , Bigl Marina , Arendt Thomas , Schliebs Reinhard 
Published: March 2015

AbstractVascular endothelial growth factor (VEGF) has been characterized as a heparin binding angiogenic growth factor displaying high specificity for endothelial cells. It is profoundly accumulated and co‐localized with amyloid beta (Aβ) plaques in the brain of Alzheimer's disease patients. In order to examine the effect of Aβ plaques on the expression level of VEGF mRNA and its receptors, brain tissue of both transgenic Tg2576 and wild type mice at ages ranging from 13 to 22 months was subjected to in situ hybridization followed by densitometric assessment using computer‐assisted image analysis. Strong expression of VEGF mRNA, fetal liver kinase (Flk)‐1 mRNA, and neuropilin (Nrp)‐1 mRNA in the piriform, entorhinal, somatosensory, frontal cortex and hippocampal formation of both transgenic and non‐transgenic mice brain was detected. Developmentally, only expression of VEGF mRNA was increased with age in the entorhinal, and somatosensory cortex of wild type mice. In 20‐month‐old transgenic Tg2576 mice, up‐regulation of VEGF mRNA, Flk‐1 mRNA, and Nrp‐1 mRNA transcripts was observed in the entorhinal cortex compared to age‐matched wild type mice. Our data suggest up‐regulation of VEGF mRNA, Flk‐1 mRNA and Nrp‐1 mRNA, at least in the entorhinal cortex at ages when Aβ deposition in Tg2576 is typically increasing.
Adirondack Park Incidents: A Retrospective Review of Search and Rescue Reports From 2008 and 2009
Authors: Sadeghi Rokhsanna , Konwinski Joseph C. , Cydulka Rita K. 
Published: March 2015

Background The Adirondack Park is a 6 million acre recreational area in northeastern New York used for activities such as hiking, camping, canoeing, hunting, fishing, snowmobiling, skiing, and rock climbing. Given the large number of people who use the Adirondacks for recreation, there exists the potential for many accidents, injuries, and illnesses to occur in areas ranging from state-operated campgrounds to remote backcountry. Objective The aim of this study was to gain insight into the demographics of search and rescue (SAR) operations in the Adirondack Park. Methods This study is a retrospective review of the Adirondack Park Forest Ranger SAR reports from January 1, 2008, through December 31, 2009. Epidemiologic data were gathered from the NY State Department of Environmental Conservation for each report, including victim demographics, incident, reason for injury, medical care needed, preparation of victim, and prior medical conditions. Results In all, 239 SAR missions were carried out involving at least 349 victims. Of all cases, 28% (66) involved an injured victim, and 9% (21) involved illness; 56% (10) of the victims had a known prior illness or medical condition; and 21% (27) of cases were due to victims exceeding their abilities. Of the search missions, 54% of victims (93) had little experience with the activity, and 9% (15) had no experience. Only 43% (62) of victims had any form of orientation equipment. Conclusions This study portrays the initial demographics of SAR efforts in Adirondack Park. It will aid in educating people on preparing for wilderness activities, as well as tailoring SAR resources to the demographics of injury and illness within the park.
Distal Junctional Disease after Occipitothoracic Fusion for Rheumatoid Cervical Disorders: Correlation with Cervical Spine Sagittal Alignment
Authors: Tanouchi Tetsu , Shimizu Takachika , Fueki Keisuke , Ino Masatake , Toda Naofumi , Manabe Nodoka , Itoh Kanako 
Published: March 2015

Study Design Retrospective radiographic study. Objective We have performed occipitothoracic (OT) fusion for severe rheumatoid cervical disorders since 1991. In our previous study, we reported that the distal junctional disease occurred in patients with fusion of O–T4 or longer due to increased mechanical stress. The present study further evaluated the association between the distal junctional disease and the cervical spine sagittal alignment. Methods Among 60 consecutive OT fusion cases between 1991 and 2010, 24 patients who underwent O–T5 fusion were enrolled in this study. The patients were grouped based on whether they developed postoperative distal junctional disease (group F) or not (group N). We measured pre- and postoperative O–C2, C2–C7, and O–C7 angles and evaluated the association between these values and the occurrence of distal junctional disease. Results Seven (29%) of 24 patients developed adjacent-level vertebral fractures as distal junctional disease. In group F, the mean pre- and postoperative O–C2, C2–C7, and O–C7 angles were 12.1 and 16.8, 7.2 and 11.2, and 19.4 and 27.9 degrees, respectively. In group N, the mean pre- and postoperative O–C2, C2–C7, and O–C7 angles were 15.9 and 15.0, 4.9 and 5.8, and 21.0 and 20.9 degrees, respectively. There were no significant differences between the two groups. The difference in the O–C7 angle (postoperative angle − preoperative angle) in group F was significantly larger than that in group N ( p = 0.04). Conclusion Excessive correction of the O–C7 angle (hyperlordotic alignment) is likely to cause postoperative distal junctional disease following the OT fusion.
A Worldwide Analysis of the Reliability and Perceived Importance of an Injury to the Posterior Ligamentous Complex in AO Type a Fractures
Authors: Schroeder Gregory D. , Kepler Christopher K. , Koerner John D. , Oner F. Cumhur , Fehlings Michael G. , Aarabi Bizhan , Dvorak Marcel F. , Reinhold Max , Kandziora Frank , Bellabarba Carlo , Chapman Jens R. , Vialle Luiz R. , Vaccaro Alexander R. 
Published: March 2015

Study Design Survey of spine surgeons. Objective To determine the reliability with which international spine surgeons identify a posterior ligamentous complex (PLC) injury in a patient with a compression-type vertebral body fracture (type A). Methods A survey was sent to all AOSpine members from the six AO regions of the world. The survey consisted of 10 cases of type A fractures (2 subtype A1, 2 subtype A2, 3 subtype A3, and 3 subtype A4 fractures) with appropriate imaging (plain radiographs, computed tomography, and/or magnetic resonance imaging), and the respondent was asked to identify fractures with a PLC disruption, as well as to indicate if the integrity of the PLC would affect their treatment recommendation. Results Five hundred twenty-nine spine surgeons from all six AO regions of the world completed the survey. The overall interobserver reliability in determining the integrity of the PLC was slight (kappa = 0.11). No substantial regional or experiential difference was identified in determining PLC integrity or its absence; however, a regional difference was identified ( p < 0.001) in how PLC integrity influenced the treatment of type A fractures. Conclusion The results of this survey indicate that there is only slight international reliability in determining the integrity of the PLC in type A fractures. Although the biomechanical importance of the PLC is not in doubt, the inability to reliably determine the integrity of the PLC may limit the utility of the M1 modifier in the AOSpine Thoracolumbar Spine Injury Classification System.
Can a Thoracolumbar Injury Severity Score be Uniformly Applied from T1 to L5 or Are Modifications Necessary?
Authors: Schroeder Gregory D. , Kepler Christopher K. , Koerner John D. , Oner F. Cumhur , Fehlings Michael G. , Aarabi Bizhan , Schnake Klaus J. , Rajasekaran Shanmuganathan , Kandziora Frank , Vialle Luiz R. , Vaccaro Alexander R. 
Published: March 2015

Study Design Literature review. Objective The aim of this review is to highlight challenges in the development of a comprehensive surgical algorithm to accompany the AOSpine Thoracolumbar Spine Injury Classification System. Methods A narrative review of the relevant spine trauma literature was undertaken with input from the multidisciplinary AOSpine International Trauma Knowledge Forum. Results The transitional areas of the spine, in particular the cervicothoracic junction, pose unique challenges. The upper thoracic vertebrae have a transitional anatomy with elements similar to the subaxial cervical spine. When treating these fractures, the surgeon must be aware of the instability due to the junctional location of these fractures. Additionally, although the narrow spinal canal makes neurologic injuries common, the small pedicles and the inability to perform an anterior exposure make decompression surgery challenging. Similarly, low lumbar fractures and fractures at the lumbosacral junction cannot always be treated in the same manner as fractures in the more cephalad thoracolumbar spine. Although the unique biomechanical environment of the low lumbar spine makes a progressive kyphotic deformity less likely because of the substantial lordosis normally present in the low lumbar spine, even a fracture leading to a neutral alignment may dramatically alter the patient's sagittal balance. Conclusion Although the new AOSpine Thoracolumbar Spine Injury Classification System was designed to be a comprehensive thoracolumbar classification, fractures at the cervicothoracic junction and the lumbosacral junction have properties unique to these junctional locations. The specific characteristics of injuries in these regions may alter the most appropriate treatment, and so surgeons must use clinical judgment to determine the optimal treatment of these complex fractures.
MSA-PAD: DNA multiple sequence alignment framework based on PFAM accessed domain information
Authors: Balech Bachir , Vicario Saverio , Donvito Giacinto , Monaco Alfonso , Notarangelo Pasquale , Pesole Graziano 
Published: March 2015

Abstract
Summary: Here we present the MSA-PAD application, a DNA multiple sequence alignment framework that uses PFAM protein domain information to align DNA sequences encoding either single or multiple protein domains. MSA-PAD has two alignment options: gene and genome mode.
Availability and Implementation: MSA-PAD is available as a web application (https://recasgateway.ba.infn.it/) and as two Taverna workflows corresponding to two alignment modes (Gene mode: http://www.myexperiment.org/workflows/4549.html; Genome Mode: http://www.myexperiment.org/workflows/4551.html).
Contact: g.pesole@ibbe.cnr.it
Supplementary information: Supplementary data are available at Bioinformatics online.
Near-IR imaging of T Cha: evidence for scattered-light disc structures at Solar system scales
Authors: Cheetham A. , Huélamo N. , Lacour S. , de Gregorio-Monsalvo I. , Tuthill P. 
Published: March 2015

Abstract
T Chamaeleontis is a young star surrounded by a transitional disc, and a plausible candidate for ongoing planet formation. Recently, a substellar companion candidate was reported within the disc gap of this star. However, its existence remains controversial, with the counter-hypothesis that light from a high-inclination disc may also be consistent with the observed data. The aim of this work is to investigate the origin of the observed closure phase signal to determine if it is best explained by a compact companion. We observed T Cha in the L′ and Ks filters with sparse aperture masking, with seven data sets covering a period of 3 years. A consistent closure phase signal is recovered in all L′ and Ks data sets. Data were fitted with a companion model and an inclined circumstellar disc model based on known disc parameters: both were shown to provide an adequate fit. However, the absence of expected relative motion for an orbiting body over the 3-year time baseline spanned by the observations rules out the companion model. Applying image reconstruction techniques to each data set reveals a stationary structure consistent with forward scattering from the near edge of an inclined disc.
Outer rotation curve of the Galaxy with VERA. II. Annual parallax and proper motion of the star-forming region IRAS 21379+5106
Authors: Nakanishi Hiroyuki , Sakai Nobuyuki , Kurayama Tomoharu , Matsuo Mitsuhiro , Imai Hiroshi , Burns Ross A. , Ozawa Takeaki , Honma Mareki , Shibata Katsunori M. , Kawaguchi Noriyuki 
Published: March 2015

Abstract
We conducted astrometric very long baseline interferometry (VLBI) observations of water-vapor maser emission in the massive star-forming region IRAS 21379+5106 in order to measure the annual parallax and proper motion, using VLBI Exploration of Radio Astrometry (VERA). The annual parallax measured 0.262 ± 0.031 mas, corresponding to a distance of $3.82^{+0.51}_{-0.41}\:$kpc. The proper motion was (μαcos δ, μδ) = (−2.74 ± 0.08, −2.87 ± 0.18) mas yr−1. By using this result, the Galactic rotational velocity was estimated to be Vθ = 218 ± 19 km s−1 at the galactocentric distance R = 9.22 ± 0.43 kpc, when we adopted the Galactic constants R0 = 8.05 ± 0.45 kpc and V0 = 238 ± 14 km s−1. With the newly determined distance, the bolometric luminosity of the central young stellar object was reestimated to be (2.15 ± 0.54) × 103 L⊙, which corresponds to the spectral type of B2–B3. The maser features were found to be distributed along a straight line extending from the southwest to the northeast. In addition, a vector map of the internal motions, constructed from the residual proper motions, implies that the maser features trace a bipolar flow, and that it cannot be explained by simple ballistic motions.
Brachytherapy-based Accelerated Partial Breast Irradiation Provides Equivalent 10-Year Outcomes to Whole Breast Irradiation
Authors: Wobb Jessica L. , Shah Chirag , Chen Peter Y. , Wallace Michelle , Ye Hong , Jawad Maha S. , Grills Inga S. 
Published: March 2015

Introduction:
Although whole breast irradiation (WBI) represents the standard radiotherapy technique in breast conserving therapy, accelerated partial breast irradiation (APBI) has emerged as an option to reduce treatment duration with comparable clinical outcomes. The purpose of this analysis is to present long-term clinical outcomes between WBI and APBI.

Methods:
A total of 3009 patients were treated with breast conserving therapy at a single institution between 1980 and 2012. Among them, 2528 patients received WBI and 481 received APBI (interstitial or balloon based). A matched-pair analysis was performed with patients matched by age (±3 years), stage (T-stage vs. T1 vs. T2), and estrogen receptor status (+/−). All patients had a minimum of 12 months follow-up. A total of 274 matches (ratio 1:1) were made.

Results:
No differences between groups were noted with respect to clinicopathologic features; WBI patients demonstrated a trend for slightly larger tumors (1.3 vs. 1.1 cm, P=0.06). At 10 years, no differences were noted with respect to rates of ipsilateral breast tumor recurrence (4% vs. 4%, P=0.11), regional recurrence (1% vs. 1%, P=0.20), contralateral breast failure (9% vs. 3%, P=0.06), or distant metastases (3% vs. 6%, P=0.47) for WBI and APBI, respectively. In addition, 10-year disease-free survival (93% vs. 91%, P=0.10) and overall survival (83% vs. 75%, P=0.34) were similar. Long-term cosmesis was good to excellent in 94% of WBI patients versus 95% of APBI patients (P=0.78).

Conclusions:
At 10 years, no differences in recurrence or survival were found between patients undergoing WBI or brachytherapy-based APBI.
Protocol for Reducing Time to Antibiotics in Pediatric Patients Presenting to an Emergency Department With Fever and Neutropenia
Authors: Cohen Clay , King Amber , Lin Chee Paul , Friedman Gregory K. , Monroe Kathy , Kutny Matthew 
Published: March 2015

Objectives
Patients with febrile neutropenia are at high risk of morbidity and mortality from infectious causes. Decreasing time to antibiotic (TTA) administration is associated with improved patient outcomes. We sought to reduce TTA for children presenting to the emergency department with fever and neutropenia.

Methods
In a prospective cohort study with historical comparison, TTA administration was evaluated in patients with neutropenia presenting to the Children's of Alabama Emergency Department. A protocol was established to reduce delays in antibiotic administration and increase the percentage of patients who receive treatment within 60 minutes of presentation. One hundred pre-protocol patient visits between August 2010 and December 2011 were evaluated and 153 post-protocol visits were evaluated between August 2012 and September 2013. We reviewed individual cases to determine barriers to rapid antibiotic administration.

Results
Antibiotics were administered in 96.9 ± 57.8 minutes in the pre-protocol patient group, and only 35% of patients received antibiotics within 60 minutes of presentation and 70% received antibiotics within 120 minutes. After implementation of the protocol, TTA for neutropenic patients was decreased to 64.3 ± 28.4 minutes (P < 0.0001) with 51.4% receiving antibiotics within 60 minutes and 93.2% within 120 minutes.

Conclusions
Implementing a standard approach to patients at risk for neutropenia decreased TTA. There are numerous challenges in providing timely antibiotics to children with febrile neutropenia. Identified delays included venous access (time to effect of topical anesthetics, and difficulty obtaining access), physicians waiting on laboratory results, and antibiotic availability.