bluuebunny/crossref_metadata_2025_split huggingface dataset:
2D Zeolite Coatings: Langmuir–Schaefer Deposition of 3 nm Thick MFI Zeolite Nanosheets
Authors: Rangnekar Neel , Shete Meera , Agrawal Kumar Varoon , Topuz Berna , Kumar Prashant , Guo Qiang , Ismail Issam , Alyoubi Abdulrahman , Basahel Sulaiman , Narasimharao Katabathini , Macosko Christopher W. , Mkhoyan K. Andre , Al‐Thabaiti Shaeel , Stottrup Benjamin , Tsapatsis Michael 
Published: April 2015

AbstractStable suspensions of zeolite nanosheets (3 nm thick MFI layers) were prepared in ethanol following acid treatment, which partially removed the associated organic structure‐directing agent. Nanosheets from these suspensions could then be dispersed at the air–water interface and transferred to silicon wafers using Langmuir–Schaefer deposition. Using layer‐by‐layer deposition, control on coating thickness was demonstrated. In‐plane X‐ray diffraction (XRD) revealed that the deposited nanosheets contract upon calcination similar to bulk MFI crystals. Different methods for secondary growth resulted in preferentially oriented thin films of MFI, which had sub‐12‐nm thickness in certain cases. Upon calcination, there was no contraction detectable by in‐plane XRD, indicating well‐intergrown MFI films that are strongly attached to the substrate.
Methylene Blue as a Photosensitizer and Redox Agent: Synthesis of 5‐Hydroxy‐1H‐pyrrol‐2(5H)‐ones from Furans
Authors: Kalaitzakis Dimitris , Kouridaki Antonia , Noutsias Dimitris , Montagnon Tamsyn , Vassilikogiannakis Georgios 
Published: April 2015

AbstractA highly efficient and general singlet‐oxygen‐initiated one‐pot transformation of readily accessible furans into 5‐hydroxy‐1H‐pyrrol‐2(5H)‐ones has been developed. The methodology was extended to the synthesis of other high‐value α,β‐unsaturated γ‐lactams. This useful set of transformations relies not only on the photosensitizing ability of methylene blue, but also on its redox properties: properties that have until now been virtually ignored in a synthetic context.
Intermolecular CH Bond Activation by a Cationic Iridium(III) Dichloride Phenanthroline Complex
Authors: Swift Christopher A. , Gronert Scott 
Published: April 2015

AbstractIt is demonstrated that a cationic iridium(III) dichloride phenanthroline complex is capable of CH activation and H/D exchange. It can cleave benzylic and unactivated secondary CH bonds, but exhibits unique selectivity when compared to similar systems that have been studied in the condensed phase. Gas‐phase rate constants and kinetic isotope effects are reported for a variety of substrates and the analysis is supported by DFT calculations at the M06/QZVP level.
High Catalytic Activity of Heteropolynuclear Cyanide Complexes Containing Cobalt and Platinum Ions: Visible‐Light Driven Water Oxidation
Authors: Yamada Yusuke , Oyama Kohei , Gates Rachel , Fukuzumi Shunichi 
Published: April 2015

AbstractA near‐stoichiometric amount of O2 was evolved as observed in the visible‐light irradiation of an aqueous buffer (pH 8) containing [RuII(2,2′‐bipyridine)3] as a photosensitizer, Na2S2O8 as a sacrificial electron acceptor, and a heteropolynuclear cyanide complex as a water‐oxidation catalyst. The heteropolynuclear cyanide complexes exhibited higher catalytic activity than a polynuclear cyanide complex containing only CoIII or PtIV ions as C‐bound metal ions. The origin of the synergistic effect between Co and Pt ions is discussed in relation to electronic and local atomic structures of the complexes.
Selective Formation of a Trisubstituted Alkene Motif by trans‐Hydrostannation/Stille Coupling: Application to the Total Synthesis and Late‐Stage Modification of 5,6‐Dihydrocineromycin B
Authors: Rummelt Stephan M. , Preindl Johannes , Sommer Heiko , Fürstner Alois 
Published: April 2015

AbstractCountless natural products of polyketide origin have an E‐configured 2‐methyl‐but‐2‐en‐1‐ol substructure. An unconventional entry into this important motif was developed as part of a concise total synthesis of 5,6‐dihydrocineromycin B. The choice of this particular target was inspired by a recent study, which suggested that the cineromycin family of antibiotics might have overlooked lead qualities, although our biodata do not necessarily support this view. The new approach consists of a sequence of alkyne metathesis followed by a hydroxy‐directed trans‐hydrostannation and a largely unprecedented methyl‐Stille coupling. The excellent yield and remarkable selectivity with which the signature trisubstituted alkene site of the target was procured is noteworthy considering the rather poor outcome of a classical ring‐closing metathesis reaction. Moreover, the unorthodox ruthenium‐catalyzed trans‐hydrostannation is shown to be a versatile handle for diversity‐oriented synthesis.
Multiscale Modeling of the Active Site of [Fe] Hydrogenase: The H2 Binding Site in Open and Closed Protein Conformations
Authors: Hedegård Erik Donovan , Kongsted Jacob , Ryde Ulf 
Published: April 2015

AbstractA series of QM/MM optimizations of the full protein of [Fe] hydrogenase were performed. The FeGP cofactor has been optimized in the water‐bound resting state (1), with a side‐on bound dihydrogen (2), or as a hydride intermediate (3). For inclusion of H4 MPT in the closed structure, advanced multiscale modeling appears to be necessary, especially to obtain reliable distances between CH‐H4MPT+ and the dihydrogen (H2) or hydride (H−) ligand in the FeGP cofactor. Inclusion of the full protein is further important for the relative energies of the two intermediates 2 and 3. We finally find that hydride transfer from 3 has a significantly higher barrier than found in previous studies neglecting the full protein environment.
Pharmacokinetic characterization of BMS‐936561, an anti‐CD70 antibody‐drug conjugate, in preclinical animal species and prediction of its pharmacokinetics in humans
Authors: Wang Haiqing , Rangan Vangipuram S. , Sung Mei‐Chen , Passmore David , Kempe Thomas , Wang Xiaoli , Thevanayagam Lourdes , Pan Chin , Rao Chetana , Srinivasan Mohan , Zhang Qian , Gangwar Sanjeev , Deshpande Shrikant , Cardarelli Pina , Marathe Punit , Yang Zheng 
Published: April 2015

AbstractCD70 is a tumor necrosis factor (TNF)‐like type II integral membrane protein that is transiently expressed on activated T‐ and B‐lymphocytes. Aberrant expression of CD70 was identified in both solid tumors and haematologic malignancies. BMS‐936561 (αCD70_MED‐A) is an antibody‐drug conjugate composed of a fully human anti‐CD70 monoclonal antibody (αCD70) conjugated with a duocarmycin derivative, MED‐A, through a maleimide‐containing citrulline‐valine dipeptide linker. MED‐A is a carbamate prodrug that is activated by carboxylesterase to its active form, MED‐B, to exert its DNA alkylation activity. In vitro serum stability studies suggested the efficiencies of hydrolyzing the carbamate‐protecting group in αCD70_MED‐A followed a rank order of mouse > rat > > monkey > dog ~ human. Pharmacokinetics of αCD70_MED‐A was evaluated in mice, monkeys, and dogs after single intravenous doses. In mice, αCD70_MED‐A was cleared rapidly, with no detectable exposures after 15 min following dosing. In contrast, αCD70_MED‐A was much more stable in monkeys and dogs. The clearance of αCD70_MED‐A in monkeys was 58 mL/d/kg, ~2‐fold faster than that in dogs (31 mL/d/kg). The human PK profiles of the total αCD70 and αCD70_MED‐A were predicted using allometrically scaled monkeys PK parameters of αCD70 and the carbamate hydrolysis rate constant estimated in dogs. Comparing the predicted and observed human PK from the phase I study, the dose‐normalized concentration‐time profiles of αCD70_MED‐A and the total αCD70 were largely within the 5th‐95th percentile of the predicted profiles. Copyright © 2015 John Wiley & Sons, Ltd.
Improving polyglucan production in cyanobacteria and microalgae via cultivation design and metabolic engineering
Authors: Aikawa Shimpei , Ho Shih‐Hsin , Nakanishi Akihito , Chang Jo‐Shu , Hasunuma Tomohisa , Kondo Akihiko 
Published: April 2015

AbstractPhotosynthetic microorganisms, such as cyanobacteria and microalgae, are currently being investigated as alternative biomass resources for bioethanol production, owing to their benefits, including high‐photosynthetic activity and whole‐year cultivation without utilization of arable land. Polyglucans comprise the major carbohydrate content of these organisms. Polyglucans can be utilized as a carbon source for microbial fermentation. Although polyglucan production has so far been promoted by nutrient limitation, it must be further enhanced to accommodate market demand. This review focuses on the recent progress in the production of α‐polyglucans such asglycogen and starch in cyanobacteria and green microalgae via cultivation design, including modifying the nutrient supply and replacing the growth medium. The control and manipulation of polyglucan metabolism necessitates the elucidation of the polyglucan production mechanism. We reviewed gene expression and metabolite accumulation profiles of cyanobacteria and green microalgae during nutrient limitation‐stimulated α‐polyglucan accumulation. We also focus on the enhancement in cyanobacterial glycogen production via the genetic engineering of glycolysis, CO2 concentration mechanism, and photosynthetic light‐harvesting protein based on the polyglucan accumulation mechanism. The combined strategies of cultivation design and genetic engineering should be considered for further enhancement of polyglucan productivity for bioethanol production.
Effect of LSKL peptide on thrombospondin 1-mediated transforming growth factor β signal activation and liver regeneration after hepatectomy in an experimental model
Authors: Kuroki H , Hayashi H , Nakagawa S , Sakamoto K , Higashi T , Nitta H , Hashimoto D , Chikamoto A , Beppu T , Baba H 
Published: April 2015

Abstract

Background
A strategy for accelerating liver regeneration after hepatectomy would offer great benefits in preventing postoperative liver failure and improving surgical outcomes. Transforming growth factor (TGF) β is a potent inhibitor of hepatocyte proliferation. Recently, thrombospondin (TSP) 1 has been identified as a negative regulator of liver regeneration by activation of local TGF-β signals. This study aimed to clarify whether the LSKL (leucine–serine–lysine–leucine) peptide, which inhibits TSP-1-mediated TGF-β activation, promotes liver regeneration after hepatectomy in mice.

Methods
Mice were operated on with a 70 per cent hepatectomy or sham procedure. Operated mice received either LSKL peptide or normal saline intraperitoneally at abdominal closure and 6 h after hepatectomy. Perioperative plasma TSP-1 levels were measured by enzyme-linked immunosorbent assay in patients undergoing hepatectomy.

Results
Administration of LSKL peptide attenuated Smad2 phosphorylation at 6 h. S-phase entry of hepatocytes was accelerated at 24 and 48 h by LSKL peptide, which resulted in faster recovery of the residual liver and bodyweight. Haematoxylin and eosin tissue staining and blood biochemical examinations revealed no significant adverse effects following the two LSKL peptide administrations. In the clinical setting, plasma TSP-1 levels were lowest on the first day after hepatectomy. However, plasma TSP-1 levels at this stage were significantly higher in patients with subsequent liver dysfunction compared with levels in those without liver dysfunction following hepatectomy.

Conclusion
Only two doses of LSKL peptide during the early period after hepatectomy can promote liver regeneration. The transient inhibition of TSP-1/TGF-β signal activation using LSKL peptide soon after hepatectomy may be a promising strategy to promote subsequent liver regeneration.Surgical relevanceAlthough the mechanisms of liver regeneration after hepatectomy have been explored intensively in vivo, no therapeutic tools are thus far available to accelerate liver regeneration after hepatectomy in the clinical setting. Recently, the matricellular protein thrombospondin (TSP) 1, a major activator of latent transforming growth factor (TGF) β1, has been identified as a negative regulator of liver regeneration after hepatectomy.In this study, the inhibition of TSP-1-mediated TGF-β signal activation by LSKL (leucine–serine–lysine–leucine) peptide in the early period after hepatectomy accelerated liver regeneration without any adverse effects. In addition, continuous high plasma TSP-1 levels after hepatectomy were associated with liver damage in humans.The transient inhibition of TSP-1/TGF-β signal activation using LSKL peptide in the early period after hepatectomy could be a novel therapeutic strategy to accelerate liver regeneration after hepatectomy.
Net neutrality and the FCC: An information policy primer
Authors: Blumenthal Karl‐Rainer 
Published: April 2015

EDITOR'S SUMMARYNet neutrality, a set of telecommunications industry standards, would deliver equal service levels for all who contribute to and use broadband Internet. The issue has been embroiled in controversy between the Federal Communications Commission (FCC) and Internet service providers, with content providers and users caught in the middle. The core of the dispute is classification under the Communications Act of 1934, to group broadband Internet as a common carrier service regulated by the FCC or to view it as an enhanced information service, ambiguously included in a 1996 amendment to the act. The FCC reinforced a regulatory framework through its Open Internet Order of 2010, stressing equity and transparency under the agency's authority. Service providers have sought to limit the FCC's control and to permit selective limiting, slowing or blocking of service to customers. The FCC's own concessions and subsequent court decisions have trimmed the agency's authority, refueling the drive to reclassify broadband Internet as a utility under the FCC's control, ensuring a telecommunications infrastructure that provides fair and equal Internet access.
Cybersecurity in the federal government: Failing to maintain a secure cyber infrastructure
Authors: Lino Christine 
Published: April 2015

EDITOR'S SUMMARYSince the first cyber‐attack in 1988, online viruses have proliferated through personal, organizational and government computers worldwide with devastating consequences. Concern was raised in 1999 regarding potential effects on the nation's poorly protected nuclear weapons, and further reports have highlighted flaws in the country's information infrastructure that put national security, public safety and personal privacy at risk. A 2014 report revealed the alarming frequency of attacks on government systems and agencies, gaps in awareness and response and minimal disclosure. Software protections are often nonexistent, ineffective or simply unused and insufficient to match rapidly advancing technology. Lack of leadership, expertise, funding, time and other resources adds to the challenge. Creation and implementation of cybersecurity policy standards have been thwarted by conflict over public and private sector roles, capabilities and inaction, and compliance with existing standards is negligible and ineffective. Joint pressure from the public and government will be needed for meaningful action.
Buying and selling information
Authors: Gruenberg Michael L. 
Published: April 2015

EDITOR'S SUMMARYWhile some individuals prefer to think they make decisions independently, uninfluenced by any salesperson, few major decisions are made without input from others. Considering another's suggestion requires trust in the person, and selling products, including information products to libraries, depends on a trusting relationship between the buyer and seller. With limited budgets, libraries must be selective in choosing subscription‐based products. Yearly renewals of a product depend not only on the quality and fit of the product but on a positive working relationship with the representative. Sales meetings demand careful preparation, with understanding of the organization's long‐ and short‐term goals and priorities. Efficient and professional meeting management and open communication demonstrate respect and reinforce trust, boosting sales and customer satisfaction.
The ASIS&T oral history program: An interim report
Authors: Williams Robert V. 
Published: April 2015

EDITOR'S SUMMARYAs part of the 75th anniversary celebration of ASIS&T, an oral history program was started to document the background, significant events and careers of outstanding individuals in information science and technology. The ongoing project takes a cue from oral histories of the Medical Library Association and the Chemical Heritage Foundation and captures individuals' experiences and decisions in their personal and professional lives, reflecting the development of the association itself. With seed funding from the ASIS&T SIG Special Projects Fund and help from graduate classes and Special Interest Group/History and the Foundations of Information Science, the initiative has relied on volunteers to identify and visit with interviewees and to record, transcribe and prepare materials for deposit in the ASIS&T archives at the University of Michigan Library. Interviews illustrate the leaps in telecommunications influencing personal careers and helping the Association in its early years, the expansion of centers for information retrieval science, bureaucratic challenges and the interplay of personalities. The ASIS&T oral history project is an important documentation of the growth of the field, capturing recordings, photos and biographies of key contributors.
Ready, engage! outreach for library data services
Authors: Mannheimer Sara 
Published: April 2015

EDITOR'S SUMMARYThe demand for data management planning and archiving is expanding, largely prompted by funding agencies, with researchers turning to librarians for help. The Montana State University library is responding with a three‐part strategy to promote data management services, focusing on partnerships, social media use and simple marketing messages. The library has partnered with university stakeholders in research development, information technology and data management, clarifying roles and integrating related efforts. Overlapping goals become points of collaboration. Social media is a growing channel for building community engagement, relying on Twitter, Facebook and a blog. Streamlined and artistically designed promotional materials highlight concise bullet points with content related to researchers' career goals.
President's page
Authors: Hirsh Sandy 
Published: April 2015

EDITOR'S SUMMARYPlans to mobilize the goals of Association president Sandy Hirsh have been put into place with feedback from focus groups and 2014 Annual Meeting attendees and the formation of several task forces. The primary goal is to develop a strategic plan for the Association, ensuring that resources align with the group's mission and members' needs. As the second goal, member attraction, engagement and retention efforts will promote membership among practitioners as a new membership category recognizing applied information science, as well as students and international members. The 2016 Annual Meeting planned for Copenhagen is an expression of the Association's global view. The third goal is for ASIS&T to advocate for the information professions, expanding understanding of professionals' diverse activities and value. ASIS&T members are encouraged to participate in these initiatives designed to strengthen the Association.
ASIS&T's social media presence: Where do we go from here?
Authors: Pennington Diane Rasmussen 
Published: April 2015

EDITOR'S SUMMARYAs part of ASIS&T's renewed attention to social media, the author extended her professional expertise with the communication channel to serve as the Association's social media manager, joining five contributors in examining members' practices and possible future directions. The Association maintains multiple social media outlets, including a listserv, accounts on Facebook, Twitter and LinkedIn, and a blog, and uses third party tools for metrics and analytics. An August 2014 survey garnered responses from 76 individuals, 58% of whom were members. Respondents clearly favored Facebook, followed by LinkedIn and Twitter, and used the services for networking and sharing resources and organizational announcements. Engaging topics are most likely to motivate participation. Responses revealed clear differences of opinion about ASIS&T's online offerings, while 26% were unaware of ASIS&T social media outlets. With the overhauled ASIS&T website, social content is prominently displayed and easy to engage with. Further strategic planning by Association president Sandy Hirsh will guide future social media activity. The author offers assistance to SIGs, chapters and committees to develop their social media presence and invites members to contribute to The ASIS&T Blog and mention ASIS&T in tweets and in Facebook and LinkedIn comments.
Mapping science introduction: Past, present and future
Authors: Börner Katy , Theriault Todd N. , Boyack Kevin W. 
Published: April 2015

EDITOR'S SUMMARYFrom early cartography to modern science maps, visual presentations facilitate understanding of large amounts of data. A traveling exhibit entitled Places and Spaces: Mapping Science has presented outstanding maps illustrating different designs and applications since 2005. The 10th year of the exhibit focuses on the future of science mapping and features five maps described in this special section of the Bulletin. Topics include the history of physics and key contributors, the development of the Internet and the structure of fields and topics in science and technology. Each emerged from latent relationships among elements in large volumes of data, made clear through visualization in an easily understandable format. Given high quality data, processing tools, design and analysis expertise and research funding, science mapping can be expected to expand in application and usefulness. Key challenges include insufficient numbers of experts, lack of sophisticated tools, low literacy in data visualization and absence of design standards.
Mapping the linguistic context of citations
Authors: Bertin Marc , Atanassova Iana , Larivière Vincent , Gingras Yves 
Published: April 2015

EDITOR'S SUMMARYScientific papers are routinely structured in sections for introduction, methods, research and discussion, a standard since the 1970s. Citations originating within each section serve different purposes and can be meaningfully classified according to position, shedding light on an author's purpose for the citation. Furthermore, words near the citations in the various sections differ, providing the basis for lexical and semantic analysis of citation contexts. Approximately 50,000 scientific papers from seven PLOS journals published between 2009 and 2012 were analyzed for citation use within the identifiable document structure and for verbs used in the context of the citations. Frequencies of verbs in the four section types demonstrate the predominant use of certain words by section. Introduction sections showed greater variety of verbs, while a more limited range of verbs was seen in Methods sections. The lexical distribution process may be applied to other contexts supporting text processing based on XML format.