bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Prolactin in Amniotic Membrane Regeneration: Therapeutic Potential for Premature Rupture of Membranes
Authors: Kong Deqi , Cho Heeryun , Hwang Soowon , Lee Ahyoung , Lee Uk , Kim Yun-Bae , Geum Dong Ho , Kim Byung-Soo , Jung Young Mi , Kim Ho Yeon , Cho Geum Joon , Ahn Kihoon , Oh Min-Jeong , Kim Hai-Joong , Cho Hee Young , Park Joong Shin , Hong SoonCheol 
Published: July 2024

Abstract
Premature rupture of membranes (PROM) is defined as rupture of fetal membranes before the onset of labor. Prolactin (PRL) is secreted by decidual membranes and accumulated significantly in the amniotic fluid during pregnancy. PRL could ameliorate inflammation and collagen degradation in fetal membranes. However, the role of PRL in amniotic membrane is not well characterized. We isolated human amniotic epithelial stem cells (hAESCs) from human fetal membranes to study the effect of PRL on proliferation, migration, and antioxidative stress. Amniotic pore culture technique (APCT) model was constructed to evaluate the tissue regeneration effect in vitro. The potential targets and pathways of PRL acting in amnion via integrated bioinformatic methods. PRL had a dose-dependent effect on hAESCs in vitro. PRL (500 ng/mL) significantly improved the viability of hAESCs and inhibited cell apoptosis, related to the upregulation of CCN2 expression and downregulation of Bax, Caspase 3, and Caspase 8. PRL accelerated migration process in hAESCs via downregulation of MMP2, MMP3, and MMP9. PRL attenuated the cellular damage and mitochondrial dysfunction induced by hydrogen peroxide in hAESCs. PRL accelerated the healing process in the APCT model significantly. The top 10 specific targets (IGF1R, SIRT1, MAP2K1, CASP8, MAPK14, MCL1, NFKB1, HIF1A, MTOR, and HSP90AA1) and signaling pathways (such as HIF signaling pathway) were selected using an integrated bioinformatics approach. PRL improves the viability and antioxidative stress function of hAESCs and the regeneration of ruptured amniotic membranes in vitro. Thus, PRL has great therapeutic potential for prevention and treatment of ruptured membranes.
Hippo pathway inactivation through subcellular localization of NF2/merlin in outer cells of mouse embryos
Authors: Goda Nanami , Ito Yui , Saito Shun , Suzuki Miyabi , Bai Hanako , Takahashi Masashi , Wakai Takuya , Kawahara Manabu 
Published: July 2024

ABSTRACT
The Hippo pathway plays a crucial role in cell proliferation and differentiation during tumorigenesis, tissue homeostasis and early embryogenesis. Scaffold proteins from the ezrin-radixin-moesin (ERM) family, including neurofibromin 2 (NF2; Merlin), regulate the Hippo pathway through cell polarity. However, the mechanisms underlying Hippo pathway regulation via cell polarity in establishing outer cells remain unclear. In this study, we generated artificial Nf2 mutants in the N-terminal FERM domain (L64P) and examined Hippo pathway activity by assessing the subcellular localization of YAP1 in early embryos expressing these mutant mRNAs. The L64P-Nf2 mutant inhibited NF2 localization around the cell membrane, resulting in YAP1 cytoplasmic translocation in the polar cells. L64P-Nf2 expression also disrupted the apical centralization of both large tumor suppressor 2 (LATS2) and ezrin in the polar cells. Furthermore, Lats2 mutants in the FERM binding domain (L83K) inhibited YAP1 nuclear translocation. These findings demonstrate that NF2 subcellular localization mediates cell polarity establishment involving ezrin centralization. This study provides previously unreported insights into how the orchestration of the cell-surface components, including NF2, LATS2 and ezrin, modulates the Hippo pathway during cell polarization.
Reprogramming macrophages with R848-loaded artificial protocells to modulate skin and skeletal wound healing
Authors: López-Cuevas Paco , Oates Tiah C. L. , Tong Qiao , McGowan Lucy M. , Cross Stephen J. , Xu Can , Zhao Yu , Yin Zhuping , Toye Ashley M. , Boussahel Asme , Hammond Chrissy L. , Mann Stephen , Martin Paul 
Published: July 2024

ABSTRACT
After tissue injury, inflammatory cells are rapidly recruited to the wound where they clear microbes and other debris, and coordinate the behaviour of other cell lineages at the repair site in both positive and negative ways. In this study, we take advantage of the translucency and genetic tractability of zebrafish to evaluate the feasibility of reprogramming innate immune cells in vivo with cargo-loaded protocells and investigate how this alters the inflammatory response in the context of skin and skeletal repair. Using live imaging, we show that protocells loaded with R848 cargo (which targets TLR7 and TLR8 signalling), are engulfed by macrophages resulting in their switching to a pro-inflammatory phenotype and altering their regulation of angiogenesis, collagen deposition and re-epithelialization during skin wound healing, as well as dampening osteoblast and osteoclast recruitment and bone mineralization during fracture repair. For infected skin wounds, R848-reprogrammed macrophages exhibited enhanced bactericidal activities leading to improved healing. We replicated our zebrafish studies in cultured human macrophages, and showed that R848-loaded protocells similarly reprogramme human cells, indicating how this strategy might be used to modulate wound inflammation in the clinic.
Energy-efficient high-speed optical modulators based on the interplay of epsilon-near-zero effect in graphene and ITO
Authors: Rafatmah Afrooz , Miri Mehdi , Yasrebi Navid 
Published: July 2024

The epsilon-near-zero effect of graphene and indium-doped tin oxide (ITO) is combined in an optical waveguide with a metal–oxide–semiconductor arrangement to provide the possibility of effective, high-speed optical modulation with low power consumption. The active waveguide is designed to induce large variations in the real and imaginary parts of the effective refractive index with an applied voltage. The proposed active waveguide is then used to design absorption and Mach–Zehnder optical modulators to perform binary and also 4- and 16-point quadrature amplitude modulation (4QAM and 16QAM). All modulators were optimized for operation at a wavelength of 1550 nm. It was shown that the proposed absorption modulator has an extinction ratio (ER) of 9.5 dB, an insertion loss (IL) of 1.4 dB, and an energy consumption of 1.57 fJ/bit. Using the Mach–Zehnder structure, binary, 4QAM, and 16QAM modulators with small active lengths of 0.6907 µm, 0.34536 µm, and 1.58 µm, respectively, are achieved. The binary modulator has an ER of 4.9 dB, an IL of 0.4 dB, an energy consumption of 6.17 fJ/bit, and the VπLπ figure of merit of 0.55 V. µm. For the 4QAM/16QAM modulators, IL, energy consumption, and the achievable bit rate are estimated to be 1.45/9.64 dB, 0.05/0.113 fJ/bit, and 500/1000 Gbit/s, respectively.
Frequency tunable optoelectronic oscillator with parity-time symmetry by using integrated components
Authors: Ahmadfard Farnaz , Hosseini S. Esmail , Qashqaei Mohammadreza 
Published: July 2024

This study introduces a parity-time (PT) symmetric, frequency-tunable optoelectronic oscillator (OEO) using integrated components within a dual-polarization Sagnac loop (SL). By leveraging the natural birefringence of a Z-cut lithium niobate (LiNbO3) phase modulator, interconnected optoelectronic loops with orthogonally polarized light waves are established—one experiencing gain and the other loss. Fine-tuning the polarization states through multiple polarization controllers (PCs) enables precise control over the gain and loss coefficients, achieving the PT symmetry breaking condition necessary to generate a stable, single-frequency microwave signal. The integrated components––the phase modulator (PM), the SL, and the photodetector (PD)––function as a microwave photonic filter (MPF). A tunable laser source combined with a microheater-tuned microdisk resonator (MDR) allows precise frequency adjustments, enabling tunable microwave frequencies from 2 to 12 GHz without additional filters. This integrated approach simplifies the system, reduces its footprint, and enhances the stability against environmental factors. Simulation results demonstrate that the proposed OEO design generates a stable, frequency-tunable microwave signal, achieving single-mode oscillation at 11.8 GHz with a phase noise of −122.5dBc/Hz at a 10 kHz offset frequency.
A qualitative evaluation of treatment fidelity alongside a pilot trial of a novel therapy for pediatric Inflammatory Bowel Disease
Authors: Olson Jenny L. , Castillo Gisell , Palumbo Amelia , Harrison Megan , Singleton Ruth , Lalu Manoj M. , Fergusson Dean A. , Stintzi Alain , Mack David R. , Presseau Justin 
Published: July 2024

Background
Process evaluations conducted alongside clinical trials can improve understanding of treatment fidelity and provide contextual knowledge to aide interpretations of trial outcomes. We adopted a multiple-goals perspective to investigate treatment fidelity in two related pilot clinical trials of an adjuvant treatment for pediatric-onset Inflammatory Bowel Disease. This included a focus on barriers and enablers of performing trial-specific activities and of integrating those activities into daily life.

Methods
We conducted one-time semi-structured interviews with a sub-sample of participants of the Resistant Starch in Pediatric Inflammatory Bowel Disease (NCT04522271) and Optimized Resistant Starch in Inflammatory Bowel Disease pilot trials (NCT04520594) and their caregivers (N = 42). The trials examined the effects of personalized food-derived resistant starches as an adjuvant therapy on intestinal microbiome functioning. Interviews were conducted within 3-months of participants completing or withdrawing from the trials. Interview guides with age-appropriate language were developed and pilot tested. Codes were identified inductively though conventional content analysis and then mapped to personal projects analysis, to explore how participants navigated between activities.

Results
Three themes were identified. The first described the potential impact of living with inflammatory bowel disease and taking prescribed medications. The second described characteristics of trial-specific activities that might impact on their enactment, including perceived difficulty, and challenges following procedures or using trial materials. The third described the integration of trial-specific activities with school, work, household demands, and social, and extracurricular activities.

Conclusions
Adjusting to living with inflammatory bowel disease and managing its treatment can impact trial participation. Integrating trial-related activities into daily life can be challenging, which could heighten perceptions of goal conflict. Findings can inform interpretations of trial outcomes and development of strategies for trial optimization and implementation of the adjuvant therapy into clinical practice.
DeepDate: A deep fusion model based on whale optimization and artificial neural network for Arabian date classification
Authors: Khalifa Nour Eldeen Mahmoud , Wang Jiaji , Hamed N. Taha Mohamed , Zhang Yudong 
Published: July 2024

Purpose
As agricultural technology continues to develop, the scale of planting and production of date fruit is increasing, which brings higher yields. However, the increasing yields also put a lot of pressure on the classification step afterward. Image recognition based on deep learning algorithms can help to identify and classify the date fruit species, even in natural light.

Method
In this paper, a deep fusion model based on whale optimization and an artificial neural network for Arabian date classification is proposed. The dataset used in this study includes five classes of date fruit images (Barhi, Khalas, Meneifi, Naboot Saif, Sullaj). The process of designing each model can be divided into three phases. The first phase is feature extraction. The second phase is feature selection. The third phase is the training and testing phase. Finally, the best-performing model was selected and compared with the currently established models (Alexnet, Squeezenet, Googlenet, Resnet50).

Results
The experimental results show that, after trying different combinations of optimization algorithms and classifiers, the highest test accuracy achieved by DeepDate was 95.9%. It takes less time to achieve a balance between classification accuracy and time consumption. In addition, the performance of DeepDate is better than that of many deep transfer learning models such as Alexnet, Squeezenet, Googlenet, VGG-19, NasNet, and Inception-V3.

Conclusion
The proposed DeepDate improves the accuracy and efficiency of classifying date fruits and achieves better results in classification metrics such as accuracy and F1. DeepDate provides a promising classification solution for date fruit classification with higher accuracy. To further advance the industry, it is recommended that stakeholders invest in technology transfer programs to bring advanced image recognition and AI tools to smaller producers, enhancing sustainability and productivity across the sector. Collaborations between agricultural technologists and growers could also foster more tailored solutions that address specific regional challenges in date fruit production.
Depressive symptoms, functional impairment, and health-related quality of life in idiopathic normal pressure hydrocephalus: A population-based study
Authors: Andersson Johanna , Maripuu Martin , Sjövill Mathilda , Lindam Anna , Laurell Katarina 
Published: July 2024

Background
Maximising quality of life is a central goal for all healthcare, especially when dealing with dementing disorders. In this study we aimed to compare health-related quality of life (HRQoL), depressive symptoms and functional impairment between individuals with and without idiopathic normal pressure hydrocephalus (iNPH) from the general population.

Methods
A total of 122 individuals, 30 with iNPH (median age 75 years, 67 females) underwent neurological examinations and computed tomography of the brain with standardised rating of imaging findings and clinical symptoms. The participants completed the Geriatric Depression Scale (GDS-15) and the HRQoL instrument EQ5D-5L. In addition, the modified Rankin Scale (mRS) was used to evaluate functional impairment.

Results
Compared with participants without iNPH, those with iNPH reported a higher score on GDS-15 (median 3 vs 1) and mRS (median 2 vs 1) (p < 0.05). Further, those with iNPH rated lower on EQ5D-5L (index 0.79, VAS 70) than those without iNPH (index 0.86, VAS 80) (p < 0.05). In logistic regression models, low HRQoL was associated with more depressive symptoms, a higher degree of iNPH symptoms, and lower functional status.

Conclusions
In this population-based sample, those with iNPH had more depressive symptoms, lower functional status, and worse quality of life compared to those without iNPH. The strongest association with low HRQoL was found for depressive symptoms, functional level, and degree of iNPH symptoms. These results underline the value of shunt surgery because of its potential to reduce symptoms and disability in iNPH and therefore improve HRQoL.
The effect of the external magnetic field on the power of the laser passing through the magnetized plasma and the calculation of the radius of convergence and the investigation of the condition of the beam's filamentation in the Medium
Authors: Karimian Hamid , Naderali Rahim , Jafari Akbar 
Published: July 2024

In this article, the power of a laser passing through a magnetized plasma medium which is affected by an external magnetic field is calculated.The change in the intensity of the magnetic field and its rotation around the axis of laser beam propagation in the plasma, on the power of the passing beam is investigated.This work is done based on the indirect effect of the magnetic field on the density distribution of electrons in the plasma, which we can consider the density changes as changes in the refractive index of the medium, so the laser power in this case is different from the case where there is no magnetic field. Also, the condition of beam filamentation has been researched as one of the third-order nonlinear phenomena, and the convergence radius has been calculated under these conditions.
Inflation Uncertainty from Firms’ Perspective, Overconfidence and Credibility of Monetary Policy
Authors: Borraz Fernando , Orlik Anna , Zacheo Laura 
Published: July 2024

Abstract
This paper uses survey data to gauge firms’ inflation uncertainty. First, it shows how commonly used proxies of uncertainty, such as ex post squared forecast errors or forecast dispersion differ from measures of actual ex ante inflation uncertainty. Second, this paper documents novel stylized facts: firms’ uncertainty and overconfidence – low ex ante variances compared to ex post (squared) forecast errors – are shown to be relevant for how firms’ form their beliefs about inflation and their inflation forecasts accuracy (firms know what they do not know) and to impact firms’ beliefs about credibility of monetary policy.
Detecting angloversal tendencies in the outer circle: a pilot study on a Maltese English speaker
Authors: Daniele Antonio 
Published: July 2024

Abstract
World Englishes constitute an ever-developing study field where keeping track of the real-time changes which occur in language usage is a challenging task. This chapter aims at broadening the application field of the research on angloversals, described in literature as particular features divergent from Standard English and shared by English varieties across the world regardless of their geographical proximity or cultural affiliation. The present qualitative study hypothesises the presence of angloversals in Maltese English and considers a blended methodological approach to verify the research hypothesis. The study was performed on selected oral excerpts taken from a random interview to a speaker of the Maltese English continuum. Both the interviewee and the interviewer are native Maltese speakers and communicated in English all throughout the interview with no instances of code mixing between the two languages. Syntactical structures containing the overuse of the progressive aspect, article omission and resumptive pronouns, as well as unmarked phonology traits have been included in the angloversal categories by previous research on the matter. Said features are particularly found in contexts where language contact has had an impact on both the substrate and superstrate languages. This is the case for the Maltese context, where explanations for the plausible presence of the above features are to be sought in the realms of transfer from Maltese to English, language universals and pragmatic principles.
Crystal structure of catena-poly[bis(μ
2-1-(3-carboxyphenyl)-5-methyl-4-oxo-1,4-dihydropyridazine-3-carboxylato-k3-O,O
′:O
″)hexaqua-dicobalt tetrahydrate], C26H36N4O20Co2
Authors: Liu Er-Nu , Tuo Meng-Qi , Liu Bo , Liu Jin , Lu Jiu-Fu 
Published: July 2024

Abstract
C26H36N4O20Co2, monoclinic, P21 (no. 4), a = 10.7226(2) Å, b = 7.41690(10) Å, c = 20.3510(3) Å, β = 90.107(1)°, V = 1618.48(4) Å3, Z = 2, R

gt
(F) = 0.0672, wR

ref
(F
2) = 0.1759, T = 293 K.
“Everyone is Furthest from Himself”: An Interpretation of Nietzsche’s Recovery and Inversion of Terence’s Formula “I Am the Closest to Myself”
Authors: Quérini Nicolas 
Published: July 2024

AbstractThis essay examines Nietzsche’s inversion of Terence’s formula “I am the closest to myself” into “Everyone is furthest from himself [Jeder ist sich selbst der Fernste]” (GM, Preface 1). In a contextual reading, I am going to ask how Nietzsche relates this formula to the difficulty of acquiring self-knowledge, as emphasized at the beginning ofOn theGenealogy of Morality. First, I argue that Nietzsche does not prohibit self-knowledge, but instead invites us to think about it differently; and second, I will show that the formula according to which “everyone is furthest from himself” can also be understood as an injunction to keep the self always at a distance. I will link these two aspects by arguing that Nietzsche replaces self-knowledge in the classical sense by an interpretation of the self, and that this interpretation must never be thought of as an undertaking that seeks to reify their self. Nietzsche urges us to make ourselves into creative projects, even this will entail fiction and illusion.
Comprehensive evaluation of the impact of ionic liquid incorporation on the optical properties, Urbach energy, thin film morphology, and surface roughness of poly(vinyl chloride) based on ionic materials
Authors: Akram Evon , Rashad Alaa A. , Rahman Mokdad Hayawi , Abed Rasheed N. , Al-Baidhani Mohammed , Basem Ali , Kadhom Mohammed , Bufaroosha Muna S. , Hadawey Abas , Yousif Emad 
Published: July 2024

Abstract
A newly synthesis composite thin films of poly(vinyl chloride) has been refinement with ionic liquid, where PVC dissolved in THF with various concentrations of IL by casting method to form the composite thin films, without any reaction and IL dangles within PVC matrix. The thin films were examined by the diffusive reflectance device under the wavelength range (238–1300 nm). The XRD, EDX, and AFM techniques were utilized to discover the structure of the PVC matrix after additive IL. The XRD analysis illustrated the amorphous structure of the films, while the EDS analysis illustrated the main composition of pure PVC and composite PVC/IL. The optical properties and optical parameters were studied. The reflectance, extinction factor, transmittance, and imaginary dielectric constant declined, the absorption value was between (80–89 %), and the refractive index, real dielectric constant, and optical conductivity were increased. The indirect energy gap declined from 4.2 eV to 2.2 eV and the direct energy gap declined from 3.7 eV to 2.6 eV. The Urbach energy was increased from 2.09 eV to 15.45 eV revealing an increase in the disorders of electrons. The E

d
increased from 23.42 eV to 70.68 eV and E

o
increased from 7.00 eV to 10.88 eV. AFM analysis illustrated the roughness of the films increased after additive IL to the PVC Matrix from 1.08 nm to 4.45 nm and the root mean square of the particles ranged from 1.57 nm to 5.56 nm. The PVC composite thin films are utilized in solar cell and sodium-ion battery applications.