bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alzheimer Disease Cerebrospinal Fluid Biomarkers Moderate Baseline Differences and Predict Longitudinal Change in Attentional Control and Episodic Memory Composites in the Adult Children Study
Authors: Aschenbrenner Andrew J. , Balota David A. , Fagan Anne M. , Duchek Janet M. , Benzinger Tammie L.S. , Morris John C. 
Published: September 2015

AbstractCognitive measures that are sensitive to biological markers of Alzheimer disease (AD) pathology are needed to (a) facilitate preclinical staging, (b) identify individuals who are at the highest risk for developing clinical symptoms, and (c) serve as endpoints for evaluating the efficacy of interventions. The present study assesses the utility of two cognitive composite scores of attentional control and episodic memory as markers for preclinical AD pathology in a group of cognitively normal older adults (N=238), as part of the Adult Children Study. All participants were given a baseline cognitive assessment and follow-up assessments every 3 years over an 8-year period, as well as a lumbar puncture within 2 years of the initial assessment to collect cerebrospinal fluid (CSF) and amyloid tracer Pittsburgh compound-B scan for amyloid imaging. Results indicated that attentional control was correlated with levels of Aβ42 at the initial assessment whereas episodic memory was not. Longitudinally, individuals with high CSF tau exhibited a decline in both attention and episodic memory over the course of the study. These results indicate that measures of attentional control and episodic memory can be used to evaluate cognitive decline in preclinical AD and provide support that CSF tau may be a key mechanism driving longitudinal cognitive change. (JINS, 2015, 21, 573–583)
Senataxin controls meiotic silencing through ATR activation and chromatin remodeling
Authors: Yeo Abrey J , Becherel Olivier J , Luff John E , Graham Mark E , Richard Derek , Lavin Martin F 
Published: September 2015

AbstractSenataxin, defective in ataxia oculomotor apraxia type 2, protects the genome by facilitating the resolution of RNA–DNA hybrids (R-loops) and other aspects of RNA processing. Disruption of this gene in mice causes failure of meiotic recombination and defective meiotic sex chromosome inactivation, leading to male infertility. Here we provide evidence that the disruption of Setx leads to reduced SUMOylation and disruption of protein localization across the XY body during meiosis. We demonstrate that senataxin and other DNA damage repair proteins, including ataxia telangiectasia and Rad3-related protein-interacting partner, are SUMOylated, and a marked downregulation of both ataxia telangiectasia and Rad3-related protein-interacting partner and TopBP1 leading to defective activation and signaling through ataxia telangiectasia and Rad3-related protein occurs in the absence of senataxin. Furthermore, chromodomain helicase DNA-binding protein 4, a component of the nucleosome remodeling and deacetylase chromatin remodeler that interacts with both ataxia telangiectasia and Rad3-related protein and senataxin was not recruited efficiently to the XY body, triggering altered histone acetylation and chromatin conformation in Setx−/− pachytene-staged spermatocytes. These results demonstrate that senataxin has a critical role in ataxia telangiectasia and Rad3-related protein- and chromodomain helicase DNA-binding protein 4-mediated transcriptional silencing and chromatin remodeling during meiosis providing greater insight into its critical role in gene regulation to protect against neurodegeneration.
A recursive vesicle-based model protocell with a primitive model cell cycle
Authors: Kurihara Kensuke , Okura Yusaku , Matsuo Muneyuki , Toyota Taro , Suzuki Kentaro , Sugawara Tadashi 
Published: September 2015

AbstractSelf-organized lipid structures (protocells) have been proposed as an intermediate between nonliving material and cellular life. Synthetic production of model protocells can demonstrate the potential processes by which living cells first arose. While we have previously described a giant vesicle (GV)-based model protocell in which amplification of DNA was linked to self-reproduction, the ability of a protocell to recursively self-proliferate for multiple generations has not been demonstrated. Here we show that newborn daughter GVs can be restored to the status of their parental GVs by pH-induced vesicular fusion of daughter GVs with conveyer GVs filled with depleted substrates. We describe a primitive model cell cycle comprising four discrete phases (ingestion, replication, maturity and division), each of which is selectively activated by a specific external stimulus. The production of recursive self-proliferating model protocells represents a step towards eventual production of model protocells that are able to mimic evolution.
Flexible coherent control of plasmonic spin-Hall effect
Authors: Xiao Shiyi , Zhong Fan , Liu Hui , Zhu Shining , Li Jensen 
Published: September 2015

AbstractThe surface plasmon polariton is an emerging candidate for miniaturizing optoelectronic circuits. Recent demonstrations of polarization-dependent splitting using metasurfaces, including focal-spot shifting and unidirectional propagation, allow us to exploit the spin degree of freedom in plasmonics. However, further progress has been hampered by the inability to generate more complicated and independent surface plasmon profiles for two incident spins, which work coherently together for more flexible and tunable functionalities. Here by matching the geometric phases of the nano-slots on silver to specific superimpositions of the inward and outward surface plasmon profiles for the two spins, arbitrary spin-dependent orbitals can be generated in a slot-free region. Furthermore, motion pictures with a series of picture frames can be assembled and played by varying the linear polarization angle of incident light. This spin-enabled control of orbitals is potentially useful for tip-free near-field scanning microscopy, holographic data storage, tunable plasmonic tweezers, and integrated optical components.
Macroscopic ordering of helical pores for arraying guest molecules noncentrosymmetrically
Authors: Li Chunji , Cho Joonil , Yamada Kuniyo , Hashizume Daisuke , Araoka Fumito , Takezoe Hideo , Aida Takuzo , Ishida Yasuhiro 
Published: September 2015

AbstractHelical nanostructures have attracted continuous attention, not only as media for chiral recognition and synthesis, but also as motifs for studying intriguing physical phenomena that never occur in centrosymmetric systems. To improve the quality of signals from these phenomena, which is a key issue for their further exploration, the most straightforward is the macroscopic orientation of helices. Here as a versatile scaffold to rationally construct this hardly accessible structure, we report a polymer framework with helical pores that unidirectionally orient over a large area (∼10 cm2). The framework, prepared by crosslinking a supramolecular liquid crystal preorganized in a magnetic field, is chemically robust, functionalized with carboxyl groups and capable of incorporating various basic or cationic guest molecules. When a nonlinear optical chromophore is incorporated in the framework, the resultant complex displays a markedly efficient nonlinear optical output, owing to the coherence of signals ensured by the macroscopically oriented helical structure.
Transcriptomes of parents identify parenting strategies and sexual conflict in a subsocial beetle
Authors: Parker Darren J. , Cunningham Christopher B. , Walling Craig A. , Stamper Clare E. , Head Megan L. , Roy-Zokan Eileen M. , McKinney Elizabeth C. , Ritchie Michael G. , Moore Allen J. 
Published: September 2015

AbstractParenting in the burying beetleNicrophorus vespilloidesis complex and, unusually, the sex and number of parents that can be present is flexible. Such flexibility is expected to involve specialized behaviour by the two sexes under biparental conditions. Here, we show that offspring fare equally well regardless of the sex or number of parents present. Comparing transcriptomes, we find a largely overlapping set of differentially expressed genes in both uniparental and biparental females and in uniparental males includingvitellogenin, associated with reproduction, andtakeout, influencing sex-specific mating and feeding behaviour. Gene expression in biparental males is similar to that in non-caring states. Thus, being ‘biparental’ inN. vespilloidesdescribes the family social organization rather than the number of directly parenting individuals. There was no specialization; instead, in biparental families, direct male parental care appears to be limited with female behaviour unchanged. This should lead to strong sexual conflict.
Carbon-bridged oligo(p-phenylenevinylene)s for photostable and broadly tunable, solution-processable thin film organic lasers
Authors: Morales-Vidal Marta , Boj Pedro G. , Villalvilla José M. , Quintana José A. , Yan Qifan , Lin Nai-Ti , Zhu Xiaozhang , Ruangsupapichat Nopporn , Casado Juan , Tsuji Hayato , Nakamura Eiichi , Díaz-García María A. 
Published: September 2015

AbstractThin film organic lasers represent a new generation of inexpensive, mechanically flexible devices for spectroscopy, optical communications and sensing. For this purpose, it is desired to develop highly efficient, stable, wavelength-tunable and solution-processable organic laser materials. Here we report that carbon-bridged oligo(p-phenylenevinylene)s serve as optimal materials combining all these properties simultaneously at the level required for applications by demonstrating amplified spontaneous emission and distributed feedback laser devices. A series of six compounds, with the repeating unit from 1 to 6, doped into polystyrene films undergo amplified spontaneous emission from 385 to 585 nm with remarkably low threshold and high net gain coefficients, as well as high photostability. The fabricated lasers show narrow linewidth (<0.13 nm) single mode emission at very low thresholds (0.7 kW cm−2), long operational lifetimes (>105 pump pulses for oligomers with three to six repeating units) and wavelength tunability across the visible spectrum (408–591 nm).
Entropy-stabilized oxides
Authors: Rost Christina M. , Sachet Edward , Borman Trent , Moballegh Ali , Dickey Elizabeth C. , Hou Dong , Jones Jacob L. , Curtarolo Stefano , Maria Jon-Paul 
Published: September 2015

AbstractConfigurational disorder can be compositionally engineered into mixed oxide by populating a single sublattice with many distinct cations. The formulations promote novel and entropy-stabilized forms of crystalline matter where metal cations are incorporated in new ways. Here, through rigorous experiments, a simple thermodynamic model, and a five-component oxide formulation, we demonstrate beyond reasonable doubt that entropy predominates the thermodynamic landscape, and drives a reversible solid-state transformation between a multiphase and single-phase state. In the latter, cation distributions are proven to be random and homogeneous. The findings validate the hypothesis that deliberate configurational disorder provides an orthogonal strategy to imagine and discover new phases of crystalline matter and untapped opportunities for property engineering.
Ultrahigh volumetric capacitance and cyclic stability of fluorine and nitrogen co-doped carbon microspheres
Authors: Zhou Junshuang , Lian Jie , Hou Li , Zhang Junchuan , Gou Huiyang , Xia Meirong , Zhao Yufeng , Strobel Timothy A. , Tao Lu , Gao Faming 
Published: September 2015

AbstractHighly porous nanostructures with large surface areas are typically employed for electrical double-layer capacitors to improve gravimetric energy storage capacity; however, high surface area carbon-based electrodes result in poor volumetric capacitance because of the low packing density of porous materials. Here, we demonstrate ultrahigh volumetric capacitance of 521 F cm−3 in aqueous electrolytes for non-porous carbon microsphere electrodes co-doped with fluorine and nitrogen synthesized by low-temperature solvothermal route, rivaling expensive RuO2 or MnO2 pseudo-capacitors. The new electrodes also exhibit excellent cyclic stability without capacitance loss after 10,000 cycles in both acidic and basic electrolytes at a high charge current of 5 A g−1. This work provides a new approach for designing high-performance electrodes with exceptional volumetric capacitance with high mass loadings and charge rates for long-lived electrochemical energy storage systems.
The body fades away: investigating the effects of transparency of an embodied virtual body on pain threshold and body ownership
Authors: Martini Matteo , Kilteni Konstantina , Maselli Antonella , Sanchez-Vives Maria V. 
Published: September 2015

AbstractThe feeling of “ownership” over an external dummy/virtual body (or body part) has been proven to have both physiological and behavioural consequences. For instance, the vision of an “embodied” dummy or virtual body can modulate pain perception. However, the impact of partial or total invisibility of the body on physiology and behaviour has been hardly explored since it presents obvious difficulties in the real world. In this study we explored how body transparency affects both body ownership and pain threshold. By means of virtual reality, we presented healthy participants with a virtual co-located body with four different levels of transparency, while participants were tested for pain threshold by increasing ramps of heat stimulation. We found that the strength of the body ownership illusion decreases when the body gets more transparent. Nevertheless, in the conditions where the body was semi-transparent, higher levels of ownership over a see-through body resulted in an increased pain sensitivity. Virtual body ownership can be used for the development of pain management interventions. However, we demonstrate that providing invisibility of the body does not increase pain threshold. Therefore, body transparency is not a good strategy to decrease pain in clinical contexts, yet this remains to be tested.
Increased epigenetic alterations at the promoters of transcriptional regulators following inadequate maternal gestational weight gain
Authors: Kawai Tomoko , Yamada Takahiro , Abe Kosei , Okamura Kohji , Kamura Hiromi , Akaishi Rina , Minakami Hisanori , Nakabayashi Kazuhiko , Hata Kenichiro 
Published: September 2015

AbstractEpigenetic modifications are thought to serve as a memory of exposure to in utero environments. However, few human studies have investigated the associations between maternal nutritional conditions during pregnancy and epigenetic alterations in offspring. In this study, we report genome-wide methylation profiles for 33 postpartum placentas from pregnancies of normal and foetal growth restriction with various extents of maternal gestational weight gain. Epigenetic alterations accumulate in the placenta under adverse in utero environments, as shown by application of Smirnov-Grubbs’ outlier test. Moreover, hypermethylation occurs frequently at the promoter regions of transcriptional regulator genes, including polycomb targets and zinc-finger genes, as shown by annotations of the genomic and functional features of loci with altered DNA methylation. Aberrant epigenetic modifications at such developmental regulator loci, if occurring in foetuses as well, will elevate the risk of developing various diseases, including metabolic and mental disorders, later in life.
Multigenerational epigenetic inheritance in humans: DNA methylation changes associated with maternal exposure to lead can be transmitted to the grandchildren
Authors: Sen Arko , Heredia Nicole , Senut Marie-Claude , Land Susan , Hollocher Kurt , Lu Xiangyi , Dereski Mary O. , Ruden Douglas M. 
Published: September 2015

AbstractWe report that the DNA methylation profile of a child’s neonatal whole blood can be significantly influenced by his or her mother’s neonatal blood lead levels (BLL). We recruited 35 mother-infant pairs in Detroit and measured the whole blood lead (Pb) levels and DNA methylation levels at over 450,000 loci from current blood and neonatal blood from both the mother and the child. We found that mothers with high neonatal BLL correlate with altered DNA methylation at 564 loci in their children’s neonatal blood. Our results suggest that Pb exposure during pregnancy affects the DNA methylation status of the fetal germ cells, which leads to altered DNA methylation in grandchildren’s neonatal dried blood spots. This is the first demonstration that an environmental exposure in pregnant mothers can have an epigenetic effect on the DNA methylation pattern in the grandchildren.
Global change feed-back inhibits cyanobacterial photosynthesis
Authors: Walter Helbling E. , Banaszak Anastazia T. , Villafañe Virginia E. 
Published: September 2015

AbstractCyanobacteria are an important component of aquatic ecosystems, with a proliferation of massive cyanobacterial blooms predicted worldwide under increasing warming conditions. In addition to temperature, other global change related variables, such as water column stratification, increases in dissolved organic matter (DOM) discharge into freshwater systems and greater wind stress (i.e., more opaque and mixed upper water column/epilimnion) might also affect the responses of cyanobacteria. However, the combined effects of these variables on cyanobacterial photosynthesis remain virtually unknown. Here we present evidence that this combination of global-change conditions results in a feed-back mechanism by which, fluctuations in solar ultraviolet radiation (UVR, 280–400 nm) due to vertical mixing within the epilimnion act synergistically with increased DOM to impair cyanobacterial photosynthesis as the water column progressively darkens. The main consequence of such a feed-back response is that these organisms will not develop large blooms in areas of latitudes higher than 30°, in both the Northern and Southern Hemispheres, where DOM inputs and surface wind stress are increasing.
Vertical transport in graphene-hexagonal boron nitride heterostructure devices
Authors: Bruzzone Samantha , Logoteta Demetrio , Fiori Gianluca , Iannaccone Giuseppe 
Published: September 2015

AbstractResearch in graphene-based electronics is recently focusing on devices based on vertical heterostructures of two-dimensional materials. Here we use density functional theory and multiscale simulations to investigate the tunneling properties of single- and double-barrier structures with graphene and few-layer hexagonal boron nitride (h-BN) or hexagonal boron carbon nitride (h-BC2N). We find that tunneling through a single barrier exhibit a weak dependence on energy. We also show that in double barriers separated by a graphene layer we do not observe resonant tunneling, but a significant increase of the tunneling probability with respect to a single barrier of thickness equal to the sum of the two barriers. This is due to the fact that the graphene layer acts as an effective phase randomizer, suppressing resonant tunneling and effectively letting a double-barrier structure behave as two single-barriers in series. Finally, we use multiscale simulations to reproduce a current-voltage characteristics resembling that of a resonant tunneling diode, that has been experimentally observed in single barrier structure. The peak current is obtained when there is perfect matching between the densities of states of the cathode and anode graphene regions.
Potential causal associations between vitamin D and uric acid: Bidirectional mediation analysis
Authors: Thakkinstian Ammarin , Anothaisintawee Thunyarat , Chailurkit Laor , Ratanachaiwong Wipa , Yamwong Sukit , Sritara Piyamitr , Ongphiphadhanakul Boonsong 
Published: September 2015

AbstractVitamin D deficiency, a major public-health worldwide, is associated with hyperuricemia but casual association is questioned. The study was conducted to determine potential causal associations between 25-hydroxy vitamin D (25(OH)D) and uric acid (UA). A cross-sectional study of the Electricity Generating Authority of Thailand (EGAT3) cohort was conducted. Subjects (n = 2,288) were used to genotype the group-specific component (GC) at rs2282679 and ATP-binding cassette subfamily G member 2 (ABCG2) at rs2231142. Mediation analysis with 1000-replication bootstrap was applied to construct causal pathways i.e., rs2282679 → 25(OH)D → UA and rs2231142 → UA → 25(OH)D: The mediator (i.e., 25(OH)D and UA) was firstly regressed on the studied gene (i.e., rs2282679 and rs2231142). A potential causal effect of C allele on UA through 25(OH)D was −0.0236 (95% CI: −0.0411, −0.0058), indicating every minor C allele resulted in decreasing the 25(OH)D and then significantly decreased the UA by 0.0236 unit. For the second pathway, the mediation effect was 0.0806 (95% CI: 0.0107, 0.1628); every T allele copy for rs2231142 increased UA and thus increased 25(OH)D by 0.0806 unit. Our study suggested potential causal associations between the GC gene and UA through the 25(OH)D mediator and the ABCG2 and the 25(OH)D through the UA mediator but the absolute effects are very clinically small.
Mitochondrial ADP/ATP exchange inhibition: a novel off-target mechanism underlying ibipinabant-induced myotoxicity
Authors: Schirris Tom J. J. , Ritschel Tina , Herma Renkema G. , Willems Peter H. G. M. , Smeitink Jan A. M. , Russel Frans G. M. 
Published: September 2015

AbstractCannabinoid receptor 1 (CB1R) antagonists appear to be promising drugs for the treatment of obesity, however, serious side effects have hampered their clinical application. Rimonabant, the first in class CB1R antagonist, was withdrawn from the market because of psychiatric side effects. This has led to the search for more peripherally restricted CB1R antagonists, one of which is ibipinabant. However, this 3,4-diarylpyrazoline derivative showed muscle toxicity in a pre-clinical dog study with mitochondrial dysfunction. Here, we studied the molecular mechanism by which ibipinabant induces mitochondrial toxicity. We observed a strong cytotoxic potency of ibipinabant in C2C12 myoblasts. Functional characterization of mitochondria revealed increased cellular reactive oxygen species generation and a decreased ATP production capacity, without effects on the catalytic activities of mitochondrial enzyme complexes I–V or the complex specific-driven oxygen consumption. Using in silico off-target prediction modelling, combined with in vitro validation in isolated mitochondria and mitoplasts, we identified adenine nucleotide translocase (ANT)-dependent mitochondrial ADP/ATP exchange as a novel molecular mechanism underlying ibipinabant-induced toxicity. Minor structural modification of ibipinabant could abolish ANT inhibition leading to a decreased cytotoxic potency, as observed with the ibipinabant derivative CB23. Our results will be instrumental in the development of new types of safer CB1R antagonists.
Longitudinal domain wall formation in elongated assemblies of ferromagnetic nanoparticles
Authors: Varón Miriam , Beleggia Marco , Jordanovic Jelena , Schiøtz Jakob , Kasama Takeshi , Puntes Victor F. , Frandsen Cathrine 
Published: September 2015

AbstractThrough evaporation of dense colloids of ferromagnetic ~13 nm ε-Co particles onto carbon substrates, anisotropic magnetic dipolar interactions can support formation of elongated particle structures with aggregate thicknesses of 100–400 nm and lengths of up to some hundred microns. Lorenz microscopy and electron holography reveal collective magnetic ordering in these structures. However, in contrast to continuous ferromagnetic thin films of comparable dimensions, domain walls appear preferentially as longitudinal, i.e., oriented parallel to the long axis of the nanoparticle assemblies. We explain this unusual domain structure as the result of dipolar interactions and shape anisotropy, in the absence of inter-particle exchange coupling.