bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maribellus mangrovi sp. nov., an iron-reducing bacterium isolated from mangrove sediment
Authors: Wang Hongxuan , Song Xiaoxuan , Xu Zhenxing , Du Zong-Jun 
Published: July 2024

A novel facultatively anaerobic and Gram-stain-negative bacterium, designated FJH33T, was isolated from mangrove sediment sampled in Zhangzhou, PR China. Cells of strain FJH33T were rod-shaped or slightly curved-shaped, with widths of 0.3–0.5 µm and lengths of 1.0–3.0 µm. Optimum growth of strain FJH33T occurred in the presence of 3 % NaCl (w/v), at 33 °C and at pH 7.0. Oxidase activity was negative, while catalase activity was positive. Its iron-reducing ability was determined. Based on 16S rRNA gene sequence similarity, strain FJH33T was most closely related to Maribellus luteus XSD2T (95.1 %), followed by Maribellus sediminis Y2-1-60T (95.0 %) and Maribellus maritimus 5E3T (94.9 %). Genome analysis of strains FJH33T and M. luteus XSD2T revealed low genome relatedness, with an average nucleotide identity value of 73.8% and a digital DNA–DNA hybridization value of 19.0%. Phylogenetic trees built from 16S rRNA genes and genome sequences showed that strain FJH33T represents a relatively independent phylogenetic lineage within the genus Maribellus. The major cellular fatty acids (≥10 %) were iso-C15 : 0 and C18 : 1
ω9c. The sole respiratory quinone was MK-7. The polar lipids consisted of phosphatidylethanolamine, diphosphatidylcholine, diphosphatidyglycerol and one unidentified lipid. The DNA G+C content was 41.4 mol%. Based on the integrated results of phylogenetic, physiological, biochemical and chemotaxonomic characterizations, we propose that strain FJH33T represents a novel species of the genus Maribellus, for which the name Maribellus mangrovi sp. nov. is proposed. The type strain is FJH33T (=KCTC 102210T=MCCC 1H01459T).
FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone
Authors: Verginadis Ioannis I. , Velalopoulou Anastasia , Kim Michele M. , Kim Kyle , Paraskevaidis Ioannis , Bell Brett , Oliaei Motlagh Seyyedeh Azar , Karaj Antoneta , Banerjee Esha , Finesso Giovanni , Assenmacher Charles-Antoine , Radaelli Enrico , Lu Jiawei , Lin Yuewei , Putt Mary E. , Diffenderfer Eric S. , Guha Chandan , Qin Ling , Metz James M. , Maity Amit , Cengel Keith A. , Koumenis Constantinos , Busch Theresa M. 
Published: July 2024

AbstractBackground and purposeThe normal tissue sparing afforded by FLASH radiotherapy (RT) is being intensely investigated for potential clinical translation. Here, we studied the effects of FLASH proton RT (F-PRT) in the reirradiation setting, with or without hypofractionation. Chronic toxicities in three murine models of normal tissue toxicity including the intestine, skin, and bone were investigated.Materials and methodsIn studies of the intestine, single-dose irradiation was performed with 12 Gy of Standard proton RT (S-PRT), followed by a second dose of 12 Gy of F-PRT or S-PRT. Additionally, a hypofractionation scheme was applied in the reirradiation setting (3 x 6.4 Gy of F-PRT or S-PRT, given every 48 hrs). In studies of skin/bone of the murine leg, 15 Gy of S-PRT was followed by hypofractionated reirradiation with F-PRT or S-PRT (3 x 11 Gy).ResultsCompared to reirradiation with S-PRT, F-PRT reduced intestinal fibrosis and collagen deposition in the reirradiation setting and significantly increased survival rate, demonstrating its protective effects on intestinal tissues. In previously irradiated leg tissues, reirradiation with hypofractionated F-PRT created transient dermatitis that fully resolved in contrast to reirradiation with hypofractionated S-PRT. Lymphedema was also alleviated after a second course of radiation with F-PRT, along with significant reductions in the accumulation of fibrous connective tissue in the skin compared to mice reirradiated with S-PRT. The delivery of a second course of fractionated S-PRT induced tibial fractures in 83.3% of the mice, whereas only 20% of mice reirradiated with F-PRT presented with fractures.ConclusionThese studies provide the first evidence of the sparing effects of F-PRT, in the setting of hypofractionated reirradiation. The results support FLASH as highly relevant to the reirradiation regimen where it exhibits significant potential to minimize chronic complications for patients undergoing RT.
Connectome predictive modeling of trait mindfulness
Authors: Treves Isaac N. , Kucyi Aaron , Park Madelynn , Kral Tammi R.A. , Goldberg Simon B. , Davidson Richard J. , Rosenkranz Melissa , Whitfield-Gabrieli Susan , Gabrieli John D.E. 
Published: July 2024

AbstractIntroductionTrait mindfulness refers to one’s disposition or tendency to pay attention to their experiences in the present moment, in a non-judgmental and accepting way. Trait mindfulness has been robustly associated with positive mental health outcomes, but its neural underpinnings are poorly understood. Prior resting-state fMRI studies have associated trait mindfulness with within- and between-network connectivity of the default-mode (DMN), fronto-parietal (FPN), and salience networks. However, it is unclear how generalizable the findings are, how they relate to different components of trait mindfulness, and how other networks and brain areas may be involved.MethodsTo address these gaps, we conducted the largest resting-state fMRI study of trait mindfulness to-date, consisting of a pre-registered connectome predictive modeling analysis in 367 adults across three samples collected at different sites.ResultsIn the model-training dataset, we did not find connections that predicted overall trait mindfulness, but we identified neural models of two mindfulness subscales,Acting with AwarenessandNon-judging. Models included both positive networks (sets of pairwise connections that positively predicted mindfulness with increasing connectivity) and negative networks, which showed the inverse relationship. TheActing with AwarenessandNon-judgingpositive network models showed distinct network representations involving FPN and DMN, respectively. The negative network models, which overlapped significantly across subscales, involved connections across the whole brain with prominent involvement of somatomotor, visual and DMN networks. Only the negative networks generalized to predict subscale scores out-of-sample, and not across both test datasets. Predictions from both models were also negatively correlated with predictions from a well-established mind-wandering connectome model.ConclusionsWe present preliminary neural evidence for a generalizable connectivity models of trait mindfulness based on specific affective and cognitive facets. However, the incomplete generalization of the models across all sites and scanners, limited stability of the models, as well as the substantial overlap between the models, underscores the difficulty of finding robust brain markers of mindfulness facets.
Spurious correlations in surface-based functional brain imaging
Authors: Jeganathan Jayson , Koussis Nikitas C , Paton Bryan , L Sina Mansour , Zalesky Andrew , Breakspear Michael 
Published: July 2024

AbstractThe study of functional MRI data is increasingly performed after mapping from volumetric voxels to surface vertices. Processing pipelines commonly used to achieve this mapping produce meshes with uneven vertex spacing, with closer neighbours in sulci compared to gyri. Consequently, correlations between the fMRI time series of neighbouring sulcal vertices are stronger than expected. However, the causes, extent, and impacts of this bias are not well understood or widely appreciated. We explain the origins of these biases, and usingin-silicomodels of fMRI data, illustrate how they lead to spurious results. The bias leads to leakage of anatomical cortical folding information into fMRI time series. We show that many common analyses can be affected by this “gyral bias”, including test-retest reliability, fingerprinting, functional parcellations, regional homogeneity, and brain-behaviour associations. Finally, we provide recommendations to avoid or remedy this spatial bias.
Quantifying ‘just-right’ APC inactivation for colorectal cancer initiation
Authors: Brunet Guasch Meritxell , Feeley Nathalie , Soriano Ignacio , Thorn Steve , Tomlinson Ian , Nicholson Michael D. , Antal Tibor 
Published: July 2024

AbstractDysregulation of the tumour suppressor gene Adenomatous Polyposis Coli (APC)is a canonical step in colorectal cancer development. Curiously, most colorectal tumours carry biallelic mutations that result in only partial loss of APC function, suggesting that a ‘just-right’ level of APC inactivation, and hence Wnt signalling, provides the optimal conditions for tumorigenesis. Mutational processes act variably across theAPCgene, which could contribute to the bias against complete APC inactivation. Thus the selective consequences of partial APC loss are unclear. Here we propose a mathematical model to quantify the tumorigenic effect of biallelicAPCgenotypes, controlling for somatic mutational processes. Analysing sequence data from >2500 colorectal cancers, we find thatAPCgenotypes resulting in partial protein function confer about 50 times higher probability of progressing to cancer compared to complete APC inactivation. The optimal inactivation level varies with anatomical location and additional mutations of Wnt pathway regulators. We use this context dependency to assess the regulatory effect of secondary Wnt drivers in combination with APCin vivo, and provide evidence that mutantAMER1combines withAPCgenotypes that lead to relatively low Wnt. The fitness landscape of APC inactivation is consistent across microsatellite unstable andPOLE-deficient colorectal cancers and tumours in patients with Familial Adenomatous Polyposis suggesting a general ‘just-right’ optimum, and pointing to Wnt hyperactivation as a potential cancer vulnerability.
The regulatory potential of transposable elements in maize
Authors: Bubb Kerry L. , Hamm Morgan O. , Tullius Thomas W. , Min Joseph K. , Ramirez-Corona Bryan , Mueth Nicholas A. , Ranchalis Jane , Mao Yizi , Bergstrom Erik J. , Vollger Mitchell R. , Trapnell Cole , Cuperus Josh T. , Stergachis Andrew B. , Queitsch Christine 
Published: July 2024

AbstractThe genomes of flowering plants consist largely of transposable elements (TEs), some of which modulate gene regulation and function. However, the repetitive nature of TEs and difficulty of mapping individual TEs by short-read-sequencing have hindered our understanding of their regulatory potential. We demonstrate that long-read chromatin fiber sequencing (Fiber-seq) comprehensively identifies accessible chromatin regions (ACRs) and CpG methylation across the maize genome. We uncover stereotypical ACR patterns at young TEs that degenerate with evolutionary age, resulting in TE-enhancers preferentially marked by a novel plant-specific epigenetic feature: simultaneous hyper-CpG methylation and chromatin accessibility. We show that TE ACRs are co-opted as gene promoters and that ACR-containing TEs can facilitate gene amplification. Lastly, we uncover a pervasive epigenetic signature – hypo-5mCpG methylation and diffuse chromatin accessibility – directing TEs to specific loci, including the loci that sparked McClintock’s discovery of TEs.
Reconciling ecology and evolutionary game theory or ‘When not to think cooperation’
Authors: Tarnita Corina E. , Traulsen Arne 
Published: July 2024

AbstractEvolutionary game theory (EGT)—overwhelmingly employed today for the study of cooperation in a variety of systems, from microbes to cancer and from insect to human societies—started with the seminal 1973 paper by John Maynard Smith and George Price [1], in which they probed the logic of limited war in animal conflict. If fighting was essential to get access to mates and territory, then why did fights rarely lead to serious injury? Maynard Smith and Price developed game theory to show that limited war can be selected at the individual level. Owing to the explanatory potential of this first paper, and enabled by the elegant and powerful machinery of the soon-to-be-developed replicator dynamics [2, 3], EGT took off at an accelerated pace and began to shape expectations across systems and scales. But, even as it expanded its reach from animals to microbes [4–8] and from microbes to cancer [9–11], the field did not revisit a fundamental assumption of that first paper, which subsequently got weaved into the very fabric of the framework—that individual differences in reproduction are determined only by payoff from the game (i.e. in isolation, all individuals, regardless of strategy, were assumed to have identical intrinsic growth rates). Here, we argue that this original assumption substantially limits the scope of EGT. But, because it is not explicitly presented as a caveat, predictions of EGT have been empirically tested broadly across real systems, where the intrinsic growth rates are generally not equal. That has, unsurprisingly, led to puzzling findings and contentious debates [7, 12–15]. Flagging the high potential for confusion to arise from applications of EGT to empirical systems that it is not designed to study and suggesting a way forward constitute our main motivation for this work. In the process, we reestablish a dialog with ecology that can be fruitful both ways, e.g., by providing a so-far-elusive explanation for how diverse ecological communities can assemble evolutionarily.
Apoptotic caspases cleave DRP1 to promote mitochondrial fusion and anti-viral immune responses
Authors: Fang Yujie , Guan Zihan , Zhu Xiangtao , Guan Zhenqiong , Li Shufen , Peng Ke 
Published: July 2024

AbstractApoptosis has been recognized as a suicidal host-defense programmed cell death pathway against invading pathogens. However, recent evidences showed that viruses can employ caspases to cleave and inactivate immune signaling molecules to facilitate infection. Whether caspases can promote anti-viral immune responses is currently unknown. Here, we demonstrated that the NSs protein of RVFV triggers activation of apoptotic caspases, which cleave the mitochondrial fission factor DRP1 resulting in mitochondrial elongation. Elongated mitochondria promote MAVS aggregation leading to enhanced anti-viral immunity. Apoptotic caspases, including caspase-3, -6, -7 and -8, cleave DRP1 at the motifs of D500FAD503and/or AEAD556, suggesting that this cleavage event may occur during infection of different viruses. Indeed, infection of H1N1, SeV and HSV-1 all triggered apoptotic caspases activation to cleave DRP1 promoting anti-viral immune responses. Compared with wild-type DRP1, introduction of caspase-resistant DRP1 strongly attenuated immune responses triggered by virus infection. These results revealed a novel mechanism through which apoptotic caspases promote anti-viral immunity by regulating mitochondrial morphodynamics.
Comparative Analysis of RT-PCR, RT-LAMP, and Antigen Testing Strategies for Effective COVID-19 Outbreak Control: A Modeling Study
Authors: Chantanasaro Tanakorn , Sararat Chayanin , Yolai Noppamas , Suttirat Pikkanet , Nawattanapaiboon Kawin , Chauvatcharin Somchai , Chadsuthi Sudarat , Modchang Charin 
Published: July 2024

AbstractThe COVID-19 pandemic has highlighted the crucial role of testing in mitigating disease transmission. This study comprehensively evaluates the effectiveness and cost-efficiency of various testing strategies, including daily screening, symptom-based testing, and contact-based testing, using assays such as RT-PCR, RT-LAMP, and antigen tests. Employing stochastic modeling on a contact network, we assessed the impact of these strategies on outbreak control, using COVID-19 as a case study. Our findings demonstrate that daily screening, particularly with RT-PCR and RT-LAMP, significantly reduces transmission risks but incurs higher costs. In contrast, symptom-based testing offers a more cost-effective alternative, albeit with lower efficacy in mitigating outbreaks. Notably, testing turnaround time emerges as a more critical factor than assay sensitivity in containing outbreaks. Moreover, combining symptom-based testing with contact tracing further reduces outbreak probability and scale. To provide a comprehensive analysis, we also explored the application of these strategies in scenarios where a portion of the population has acquired immunity. Our results suggest that testing all symptomatic individuals is the most effective and cost-efficient approach in the later stages of an epidemic. These findings provide valuable insights for optimizing testing strategies to tackle current and future infectious disease outbreaks effectively and efficiently. By adapting strategies based on the stage of the epidemic, population immunity, and available resources, public health authorities can design targeted interventions to protect communities while managing limited resources.
In situ photodeposition of ultra-small palladium particles on TiO2
Authors: Kozyr Elizaveta , Martí-Sánchez Sara , Skorynina Alina , Arbiol Jordi , Escudero Carlos , Mino Lorenzo , Bugaev Aram 
Published: July 2024

In situ and operando investigation of photocatalysts plays a fundamental role in understanding the processes of active phase formation and the mechanisms of catalytic reactions, which is crucial for the rational design of more efficient materials. Using a custom-made operando photocatalytic cell, an in situ procedure to follow the formation steps of Pd/TiO2 photocatalyst by synchrotron-based X-ray absorption spectroscopy (XAS) is proposed. The procedure resulted in the formation of ∼1 nm Pd particles with a much narrower size distribution and homogeneous spreading over TiO2 support compared with the samples generated in a conventional batch reactor. The combination of in situ XAS spectroscopy with high-angle annular dark-field scanning transmission electron microscopy demonstrated the formation of single-atom Pd(0) sites on TiO2 as the initial step of the photodeposition process. Palladium hydride particles were observed for all investigated samples upon exposure to formic acid solutions.
Is internationalization abroad a prerequisite for university students' intercultural competence development?
Authors: Wang Xiaoqing , Shen Yuting 
Published: July 2024

PurposeThis study aims to examine how intercultural competence (IC) among university students can be enhanced through two streams of higher education internationalization: internationalization abroad and internationalization at home (IaH). By doing so, it aims to improve university students' IC through identifying which factors are more effective in fostering IC.Design/methodology/approachThe study is not solely a literature review, but rather a conceptual exploration based on a selective review of the literature. Due to the exploratory nature of this study, we employed a thematic analysis approach to reviewing English language literature while incorporating relevant Chinese literature to ensure a more balanced representation.FindingsWe found that international students’ IC is influenced by their overseas learning experiences, which are closely related to the duration of stay, language proficiency, intercultural contact, university management and teachers and administrative support. On the other hand, domestic students’ IC has been influenced by various IaH experiences primarily within their home university campus, such as foreign language learning, international curriculum, extracurricular activities, communication between domestic and international students, integrated management of international students, the use of Internet and communication technology and so forth. Although a direct and definitive comparison is lacking, some comparative analyses suggest that IaH experiences may yield better results in enhancing the IC of domestic students.Originality/valueThis article advances the understanding of IC development. We call for further research that values the importance of IaH in the increasingly uncertain globalization and delves into comparative analysis of the effects of two streams of higher education internationalization.
On primality of Cartesian product of graphs
Authors: El Amri Nadia , Boudabbous Imed , Yaich Mouna 
Published: July 2024

PurposeThe present work focuses on the primality and the Cartesian product of graphs.Design/methodology/approachGiven a graph G, a subset M of V (G) is a module of G if, for a, b ∈ M and x ∈ V (G) \ M, xa ∈ E(G) if and only if xb ∈ E(G). A graph G with at least three vertices is prime if the empty set, the single-vertex sets and V (G) are the only modules of G.FindingsMotivated by works obtained on “the Cartesian product of graphs” and “the primality,” this paper creates a link between the two notions.Originality/valueIn fact, we study the primality of the Cartesian product of two connected graphs minus k vertices, where k ∈ {0, 1, 2}.
Is all that glitters gold? Exploring sustainability and business ethics education in ethics-friendly environments
Authors: Seguí-Mas Elies , Tormo-Carbó Guillermina , Sigurjonsson Throstur Olaf , Arnardóttir Auður Arna 
Published: July 2024

Purpose
This study aims to identify students’ perceptions of the importance and objectives of sustainability and business ethics education, considering contextual factors (ethics-friendly environments) and including the social desirability (SD) bias to strengthen data robustness and assess response truthfulness.

Design/methodology/approach
A survey was administered to 170 business students at an Icelandic university to measure their attitudes and perceptions toward sustainability and business ethics courses. Descriptive statistics, Mann–Whitney tests, χ2 tests and multivariate regression were used for the analysis.

Findings
The results show no significant differences among participants, depending on individual and organizational factors. The authors did not find significant differences in gender, age or exposure to sustainability and business ethics courses concerning social desirability bias. Contextual solid factors can explain these results.

Originality/value
This study expands on previous research by examining students’ perceptions of sustainability and business ethics education in an “ethics-friendly environment” like Iceland, a new and fertile territory for business ethics education research. These elements are crucial for further research on students’ attitudes toward sustainability and business ethics and the role of this subject in university curricula.
Tribological properties and synergistic effects of ionic liquids and silver complexes
Authors: Sun Long , Jin Chengjie , Tang Xiaodong , Cao Kexin , Wang Songquan , Hu Ningning 
Published: July 2024

Purpose
The purpose of this paper is to solve the abrupt deterioration of lubricant performance in high-temperature conditions.

Design/methodology/approach
Three silver pyrazolyl methyl pyridine complexes with different morphologies were synthesized. A four-ball tribometer was used to assess the tribological characteristics as an additive for pentaerythritol oleate both independently and compound with 1-hexyl-3-methylimidazolium bis(trifluoromethane sulfonyl)imide.

Findings
The results showed that when silver complexes and ionic liquids (IL) act independently, sheet silver complex 1 and rod silver complex 2 exhibit good lubricating performance; the optimal antifriction concentration of the ILs is 0.25 Wt.%. The tribological results of the compounds additive of ILs and silver complexes indicate that the wear scar diameter of compound 1 decreased by 16.914%, the wear volume reduced by 7.44% and the lubrication effect surpassed that of the two substances individually; rod compound 2 exhibited an antagonistic effect, intensifying wear; compound 3’s lubrication effect fell between that of the two individual components.

Originality/value
The compound of sheet silver complexes and ILs effectively solves the agglomeration problem of micro/nano lubricant additives. When the interface fails, self-repair is completed, improving the stability and antiwear performance of the lubricating oil.

Peer review
The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-04-2024-0128