bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical elements in implementations of just-in-time management: empirical study of cement industry in Pakistan
Authors: Qureshi Muhammad Imran , Iftikhar Mehwish , Bhatti Mansoor Nazir , Shams Tauqeer , Zaman Khalid 
Published: December 2013

AbstractIn recent years, inventory management is continuous challenge for all organizations not only due to heavy cost associated with inventory holding, but also it has a great deal to do with the organizations production process. Cement industry is a growing sector of Pakistan’s economy which is now facing problems in capacity utilization of their plants. This study attempts to identify the key strategies for successful implementation of just-in-time (JIT) management philosophy on the cement industry of Pakistan. The study uses survey responses from four hundred operations’ managers of cement industry in order to know about the advantages and benefits that cement industry have experienced by Just in time (JIT) adoption. The results show that implementing the quality, product design, inventory management, supply chain and production plans embodied through the JIT philosophy which infect enhances cement industry competitiveness in Pakistan. JIT implementation increases performance by lower level of inventory, reduced operations & inventory costs was reduced eliminates wastage from the processes and reduced unnecessary production which is a big challenge for the manufacturer who are trying to maintain the continuous flow processes. JIT implementation is a vital manufacturing strategy that reaches capacity utilization and minimizes the rate of defect in continuous flow processes. The study emphasize the need for top management commitment in order to incorporate the necessary changes that need to take place in cement industry so that JIT implementation can take place in an effective manner.
Bridges or buffers? Motives behind Immigrants’ Religiosity
Authors: Garcia-Muñoz Teresa , Neuman Shoshana 
Published: December 2013

AbstractThis study reviews and evaluates the motives and incentives behind immigrants’ religiosity, focusing on the two sides of the Atlantic – Europe and the United States. The contribution of the study is mainly empirical, trying to identify indicators for the type of incentive – whether immigrants’ religiosity serves as a ‘bridge’ or a ‘buffer’ in the process of adaptation to the receiving country. The statistical analysis draws on data from several waves of the European Social Survey (ESS), the American General Social Survey (GSS), and the International Social Survey Program (ISSP). Estimation of extended ‘mass participation equations’ and ‘prayer equations’ leads to the following findings: (a) immigrants are indeed more religious than the populations in the receiving countries, both in Europe and in the United States; and (b) while in the United States the religiosity of immigrants serves as a bridge between the immigrants and the local population, in Europe it has mainly the function of a buffer and of a “balm for the soul”. There is an extensive literature on the ‘bridge versus buffer’ (or ‘bridge versus boundary’) theories and their different implications in the United States and in Europe. However, to the best of our knowledge, our paper presents an innovative attempt to disentangle the two types of motives and to show that while the former is more relevant in the United States, the latter dominates in Europe.JEL codesJ11; J15; Z12; Z13
High-Dose Cytarabine in Induction Treatment Improves the Outcome of Adult Patients Younger Than Age 46 Years With Acute Myeloid Leukemia: Results of the EORTC-GIMEMA AML-12 Trial
Authors: Willemze Roelof , Suciu Stefan , Meloni Giovanna , Labar Boris , Marie Jean-Pierre , Halkes Constantijn J.M. , Muus Petra , Mistrik Martin , Amadori Sergio , Specchia Giorgina , Fabbiano Francesco , Nobile Francesco , Sborgia Marco , Camera Andrea , Selleslag Dominik L.D. , Lefrère Francois , Magro Domenico , Sica Simona , Cantore Nicola , Beksac Meral , Berneman Zwi , Thomas Xavier , Melillo Lorella , Guimaraes Jose E. , Leoni Pietro , Luppi Mario , Mitra Maria E. , Bron Dominique , Fillet Georges , Marijt Erik W.A. , Venditti Adriano , Hagemeijer Anne , Mancini Marco , Jansen Joop , Cilloni Daniela , Meert Liv , Fazi Paola , Vignetti Marco , Trisolini Silvia M. , Mandelli Franco , de Witte Theo 
Published: December 2013

Purpose Cytarabine plays a pivotal role in the treatment of patients with acute myeloid leukemia (AML). Most centers use 7 to 10 days of cytarabine at a daily dose of 100 to 200 mg/m2 for remission induction. Consensus has not been reached on the benefit of higher dosages of cytarabine. Patients and Methods The European Organisation for Research and Treatment of Cancer (EORTC) and Gruppo Italiano Malattie Ematologiche dell' Adulto (GIMEMA) Leukemia Groups conducted a randomized trial (AML-12; Combination Chemotherapy, Stem Cell Transplant and Interleukin-2 in Treating Patients With Acute Myeloid Leukemia) in 1,942 newly diagnosed patients with AML, age 15 to 60 years, comparing remission induction treatment containing daunorubicin, etoposide, and either standard-dose (SD) cytarabine (100 mg/m2 per day by continuous infusion for 10 days) or high-dose (HD) cytarabine (3,000 mg/m2 every 12 hours by 3-hour infusion on days 1, 3, 5, and 7). Patients in complete remission (CR) received a single consolidation cycle containing daunorubicin and intermediate-dose cytarabine (500 mg/m2 every 12 hours for 6 days). Subsequently, a stem-cell transplantation was planned. The primary end point was survival. Results At a median follow-up of 6 years, overall survival was 38.7% for patients randomly assigned to SD cytarabine and 42.5% for those randomly assigned to HD cytarabine (log-rank test P = .06; multivariable analysis P = .009). For patients younger than age 46 years, survival was 43.3% and 51.9%, respectively (P = .009; multivariable analysis P = .003), and for patients age 46 to 60 years, survival was 33.9% and 32.9%, respectively (P = .91). CR rates were 72.0% and 78.7%, respectively (P < .001) and were 75.6% and 82.4% for patients younger than age 46 years (P = .01) and 68.3% and 74.8% for patients age 46 years and older (P = .03). Patients of all ages with very-bad-risk cytogenetic abnormalities and/or FLT3-ITD (internal tandem duplication) mutation, or with secondary AML benefitted from HD cytarabine. Conclusion HD cytarabine produces higher remission and survival rates than SD cytarabine, especially in patients younger than age 46 years.
Bad sex and obscene undertakings: Ken Russell’s Women in Love
Authors: Williams Linda Ruth 
Published: December 2013

Abstract
This article examines how issues of fidelity and adaptation influenced the reception of Ken Russell’s Women in Love (1969) and its classification by the British Board of Film Censors at a galvanizing moment in British sexual history. Through the focus of Russell’s reading of D. H. Lawrence it opens up some wider questions about the fluctuating histories of adaptation, censorship, and liberty. The files documenting the classification of Women in Love held at the BBFC tell an important censorship story from a particularly incandescent cinematic moment.
Slow evolution: ‘First time fics’ and The X-Files porn parody
Authors: Jones Bethan 
Published: December 2013

Abstract
Chris Carter once said that he ‘didn’t want [The X-Files] to be another Moonlighting. [He] didn’t want the relationship to come before the cases’, ruling out the possibility of a relationship between the two main characters. While this did, ultimately, change by the end of the show’s run, the unresolved sexual tension that existed through the course of the series, particularly in seasons one to seven, gave fan fiction writers fuel with which to create their own erotic adaptations of the show. For a fandom that coined the term ‘shipper’, it is not surprising that a large amount of fan fiction concerning Mulder and Scully’s relationship has been written. It is less surprising that a high percentage of these deal with the first sexual encounter between the two agents. But this is also a subject that The Sex Files: A Dark XXX Parody (Hain, 2009) has chosen to explore. In this article I explore the interaction between the canon text, the fan fiction that has arisen from it, and The Sex Files, to examine the appeal of first time fics and the ways in which prior readings of the text(s) led to the fan readings of the porn parody.
There’s something rotten in the state of Texas: Genre, adaptation and The Texas Vibrator Massacre
Authors: Watson Thomas 
Published: December 2013

Abstract
The main focus of this article is to critically assess the recent hardcore porn film The Texas Vibrator Massacre. Following the decision of the British Board of Film Classification (BBFC) to ban the film in August 2008, this article explores the contexts of such regulatory control in response to what has proven to be a problematic conflation of hardcore porn and horror. Although the film is coded as a sex work, its callous tone and representations of violence have meant that the film complicates what is, on the surface, a pornographic parody film. Using the rejection of the film as a starting point, the article explores the now conventional porn parody sub-genre and how Rob Rotten positions himself in relation to this type of pornography. Moving beyond issues of parody and into the controversial representation of sexual violence, I position The Texas Vibrator Massacre as an example of both hardcore porn and graphic horror that problematizes the critical assessment of these respective genres. In discussing the film through the prism of censorship and the practicalities of classification, I argue how this framework of regulation can be used to outline the wider implications of conflating horror and hard-core pornography.
An excess of positions: The adaptation of Secret Diary of a Call Girl from blog to box
Authors: Knowles Joanne 
Published: December 2013

Abstract
This article focuses on the television series Secret Diary of a Call Girl as an adaptation of popular, but explicit and problematic, material for the avowedly mainstream television channel that commissioned and screened it, ITV2. Adapted from Belle du Jour’s blog and print memoirs about life as a high-class sex worker, the texts’ sexual content and erotic appeal necessarily varied when adapted from one media platform to another, but also proved a landmark success for ITV2 in shaping a distinctive channel identity. The article examines Secret Diary of a Call Girl’s strategy of operating in both comic and erotic modes to offer recognizable satisfactions to different audience groups, and explored the way in which its exploration of feminine sexuality as performance is augmented by this comedic structuring of the narrative. The article also attends in particular to two particular aspects of the adaptation: its visual strategies in shots and positioning of its protagonist, and its institutional and generic context, using Tony Bennett’s research on television viewing and cultural capital to explore the role of the series as reputation enhancing for ITV2 in being positioned as ‘original drama’ whilst also drawing viewer interest by offering multiple spectator positions to audiences in order to make available varied viewing pleasures for a heterogeneous range of viewers.
Physical Activity in Overweight and Obese Pregnant Women Is Associated With Higher Levels of Proinflammatory Cytokines and With Reduced Insulin Response Through Interleukin-6
Authors: van Poppel Mireille N.M. , Peinhaupt Miriam , Eekhoff Marelise E.W. , Heinemann Akos , Oostdam Nicolette , Wouters Maurice G.A.J. , van Mechelen Willem , Desoye Gernot 
Published: December 2013

OBJECTIVE
Previously, we reported the positive association of moderate-to-vigorous physical activity (MVPA) with insulin sensitivity in overweight and obese pregnant women. We sought to assess whether these MVPA-induced changes in insulin sensitivity are mediated by changes in interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, and IL-1β.

RESEARCH DESIGN AND METHODS
A prospective longitudinal study was conducted in 46 overweight and obese women at risk for gestational diabetes mellitus. Objective physical activity measurements and fasting blood samples were taken at 15, 24, and 32 weeks of pregnancy. At 24 and 32 weeks, a 100-g oral glucose test was performed in addition. Cytokines, C-reactive protein, and glucose and insulin levels were measured, and insulin sensitivity and first-phase insulin response were calculated. Relationships between the different parameters were assessed using linear regression models, adjusting for maternal age and BMI.

RESULTS
All cytokines were elevated in women with higher levels of MVPA at 15 weeks of gestation. Higher IL-6 was related to a lower first-phase insulin response (β −810.5 [95% CI –1,524.5 to –96.5]; P = 0.03). TNF-α and IL-1β had different effects in women with low MVPA (with low IL-6 levels) compared with more active women. CRP was not related to MVPA.

CONCLUSIONS
The association of MVPA with insulin sensitivity and first-phase insulin response may be (partly) mediated by IL-6, since this cytokine was related to reduced first-phase insulin response. The possible positive effects of the elevated cytokine profile in active obese pregnant women warrant further study.
Genomic and transcriptome analysis revealing an oncogenic functional module in meningiomas
Authors: Chang Xiao , Shi Lingling , Gao Fan , Russin Jonathan , Zeng Liyun , He Shuhan , Chen Thomas C. , Giannotta Steven L. , Weisenberger Daniel J. , Zada Gabriel , Wang Kai , Mack William J. 
Published: December 2013

Object
Meningiomas are among the most common primary adult brain tumors. Although typically benign, roughly 2%–5% display malignant pathological features. The key molecular pathways involved in malignant transformation remain to be determined.

Methods
Illumina expression microarrays were used to assess gene expression levels, and Illumina single-nucleotide polymorphism arrays were used to identify copy number variants in benign, atypical, and malignant meningiomas (19 tumors, including 4 malignant ones). The authors also reanalyzed 2 expression data sets generated on Affymetrix microarrays (n = 68, including 6 malignant ones; n = 56, including 3 malignant ones). A weighted gene coexpression network approach was used to identify coexpression modules associated with malignancy.

Results
At the genomic level, malignant meningiomas had more chromosomal losses than atypical and benign meningiomas, with average length of 528, 203, and 34 megabases, respectively. Monosomic loss of chromosome 22 was confirmed to be one of the primary chromosomal level abnormalities in all subtypes of meningiomas. At the transcriptome level, the authors identified 23 coexpression modules from the weighted gene coexpression network. Gene functional enrichment analysis highlighted a module with 356 genes that was highly related to tumorigenesis. Four intramodular hubs within the module (GAB2, KLF2, ID1, and CTF1) were oncogenic in other cancers such as leukemia. A putative meningioma tumor suppressor MN1 was also identified in this module with differential expression between malignant and benign meningiomas.

Conclusions
The authors' genomic and transcriptome analysis of meningiomas provides novel insights into the molecular pathways involved in malignant transformation of meningiomas, with implications for molecular heterogeneity of the disease.
Extracranial ligation of ethmoidal arteries before resection of giant olfactory groove or planum sphenoidale meningiomas: 3 illustrative cases with a review of the literature on surgical techniques
Authors: Manjila Sunil , Cox Efrem M. , Smith Gabriel A. , Corriveau Mark , Chhabra Nipun , Johnson Freedom , Geertman Robert T. 
Published: December 2013

Object
There are several surgical techniques for reducing blood loss—open surgical and endoscopic—prior to resection of giant anterior skull base meningiomas, especially when preoperative embolization is risky or not technically feasible. The authors present examples of an institutional experience using surgical ligation of the anterior and posterior ethmoidal arteries producing persistent tumor blush in partially embolized tumors.

Methods
The authors identified 12 patients who underwent extracranial surgical ligation of ethmoidal arteries through either a transcaruncular or a Lynch approach. Of these, 3 patients had giant olfactory groove or planum sphenoidale meningiomas. After approval from the institution privacy officer, the authors studied the medical records and imaging data of these 3 patients, with special attention to surgical technique and outcome. The variations of ethmoidal artery foramina pertaining to this surgical approach were studied using preserved human skulls from the Hamann-Todd Osteological Collection at the Museum of Natural History, Cleveland, Ohio.

Results
The extracranial ligation was performed successfully for control of the ethmoidal arteries prior to resection of hypervascular giant anterior skull base meningiomas. The surgical anatomy and landmarks for ethmoidal arteries were reviewed in anthropology specimens and available literature with reference to described surgical techniques.

Conclusions
Extracranial surgical ligation of anterior, and often posterior, ethmoidal arteries prior to resection of large olfactory groove or planum sphenoidale meningiomas provides a safe and feasible option for control of these vessels prior to either open or endoscopic resection of nonembolized or partially embolized tumors.
Recent developments in chemotherapy for meningiomas: a review
Authors: Moazzam Alan A. , Wagle Naveed , Zada Gabriel 
Published: December 2013

Object
Currently, few medical options exist for refractory and atypical/anaplastic meningiomas. New developments in chemotherapeutic options for meningiomas have been explored over the past decade. The authors review these recent developments, with an emphasis on emerging avenues for therapy, clinical efficacy, and adverse effects.

Methods
A review of the literature was performed to identify any studies exploring recent medical and chemotherapeutic agents that have been or are currently being tested for meningiomas. Results from included preclinical and human clinical trials were reviewed and summarized.

Results
Current guidelines recommend only 3 drugs that can be used to treat patients with refractory and highgrade meningiomas: hydroxyurea, interferon-α 2B, and Sandostatin long-acting release. Recent developments in the medical treatment of meningiomas have been made across a variety of pharmacological classes, including cytotoxic agents, hormonal agents, immunomodulators, and targeted agents toward a variety of growth factors and their signaling cascades. Promising avenues of therapy that are being evaluated for efficacy and safety include antagonists of platelet-derived growth factor receptor, epidermal growth factor receptor, vascular endothelial growth factor receptor, and mammalian target of rapamycin. Because malignant transformation in meningiomas is likely to be mediated by numerous processes interacting via a complex matrix of signals, combination therapies affecting multiple molecular targets are currently being explored and hold significant promise as adjuvant therapy options.

Conclusions
Improved understanding of the molecular mechanisms driving meningioma tumorigenesis and malignant transformation has resulted in the targeted development of more specific agents for chemotherapeutic intervention in patients with nonresectable, aggressive, and malignant meningiomas.
Technical nuances in the management of tuberculum sellae and diaphragma sellae meningiomas
Authors: Nanda Anil , Ambekar Sudheer , Javalkar Vijayakumar , Sharma Mayur 
Published: December 2013

Object
Tuberculum sellae meningiomas (TSMs) and diaphragma sellae meningiomas (DSMs) are challenging lesions to treat due to their proximity to neurovascular structures.

Methods
The authors reviewed the medical records of patients who underwent surgical excision of TSMs and DSMs from 1990 to 2013. They also describe the technical strategies used to minimize injury to the optic apparatus, vascular structures, and pituitary stalk.

Results
Twenty-four patients with TSM and 6 patients with DSM were included in the study. Seventy percent of the tumors were large (≥ 5 cm). The pterional approach was employed in most cases. Optic canal involvement was observed in 4 patients. Twenty-one patients (70%) had visual dysfunction before surgery. At follow-up (median 18 months), visual improvement was noted in 10 (47.6%) of 21 patients. Gross-total excision was achieved in 22 patients (91.6%) with TSM and 5 (83.3%) with DSM. At last follow-up, 28 patients (93.3%) had a Glasgow Outcome Scale score of 5. There were no deaths in this series.

Conclusions
Tuberculum and diaphragma sellae meningiomas present a unique subset of tumors due to their location. They can be safely excised with minimal morbidity and mortality using microsurgical techniques. Attention to technical details during surgery leads to greater respectability and superior visual outcome.
A review of epigenetic and gene expression alterations associated with intracranial meningiomas
Authors: He Shuhan , Pham Martin H. , Pease Matthew , Zada Gabriel , Giannotta Steven L. , Wang Kai , Mack William J. 
Published: December 2013

Object
A more comprehensive understanding of the epigenetic abnormalities associated with meningioma tumorigenesis, growth, and invasion may provide useful targets for molecular classification and development of targeted therapies for meningiomas.

Methods
The authors performed a review of the current literature to identify the epigenetic modifications associated with the formation and/or progression of meningiomas.

Results
Several epigenomic alterations, mainly pertaining to DNA methylation, have been associated with meningiomas. Hypermethylation of TIMP3 inactivates its tumor suppression activity while CDKN2 (p14[ARF]) and TP73 gene hypermethylation and HIST1H1c upregulation interact with the p53 regulation of cell cycle control. Other factors such as HOX, IGF, WNK2, and TGF-β epigenetic modifications allow either upregulation or downregulation of critical pathways for meningioma development, progression, and recurrence.

Conclusions
Genome-wide methylation profiling demonstrated that global hypomethylation correlates with tumor grades and severity. Identification of additional epigenetic changes, such as histone modification and higher-order chromosomal structure, may allow for a more thorough understanding of tumorigenesis and enable future individualized treatment strategies for meningiomas.