bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Single Platelet-Rich Plasma Injection for Chronic Midsubstance Achilles Tendinopathy
Authors: Murawski Christopher D. , Smyth Niall A. , Newman Hunter , Kennedy John G. 
Published: April 2014

The purpose of this study was to evaluate a series of patients undergoing a single platelet-rich plasma (PRP) injection for the treatment of chronic midsubstance Achilles tendinopathy, in whom conservative treatment had failed. Thirty-two patients underwent a single PRP injection for the treatment of chronic midsubstance Achilles tendinopathy and were evaluated at a 6-month final follow-up using the Foot and Ankle Outcome Score and Short Form 12 general health questionnaire. Magnetic resonance imaging was performed on all patients prior to and 6 months after injection. Twenty-five of 32 patients (78%) reported that they were asymptomatic at the 6-month follow-up visit and were able to participate in their respective sports and daily activities. The remaining 7 patients (22%) who reported symptoms that did not improve after 6 months ultimately required surgery. Four patients went on to have an Achilles tendoscopy, while the other 3 had an open debridement via a tendon splitting approach. A retrospective evaluation of patients receiving a single PRP injection for chronic midsubstance Achilles tendinopathy revealed that 78% had experienced clinical improvement and had avoided surgical intervention at 6-month follow-up. Levels of Evidence: Therapeutic, Level IV: Retrospective case series
Alternate Histories
Authors: Muralidharan Sukumar 
Published: May 2014

The past is never dead. It is not even past—William Faulkner This article reviews recent literature on the accession of the princely state of Hyderabad to the Indian union in 1948, in the context of events that have raised the temperature of communal confrontation in the region. Scholarship on nation formation has drawn attention to the role that the act of remembering only to forget, plays in cementing a sense of nationalist solidarity. By that criterion, the accession of Hyderabad presents a case of historical record that may have been abridged and in part effaced, without the consent of its more substantial minority group. This allows for historical tensions to emerge anew as fault-lines where modern democratic competition could spill over into communal antagonism. Recent efforts to restore the historical record, one by way of a memoir and the other, a work of archival scholarship, assume great importance in this regard.
De novo genome assembly of the soil-borne fungus and tomato pathogen Pyrenochaeta lycopersici
Authors: Aragona Maria , Minio Andrea , Ferrarini Alberto , Valente Maria Teresa , Bagnaresi Paolo , Orrù Luigi , Tononi Paola , Zamperin Gianpiero , Infantino Alessandro , Valè Giampiero , Cattivelli Luigi , Delledonne Massimo 
Published: April 2014

AbstractBackgroundPyrenochaeta lycopersiciis a soil-dwelling ascomycete pathogen that causes corky root rot disease in tomato (Solanum lycopersicum) and otherSolanaceouscrops, reducing fruit yields by up to 75%. Fungal pathogens that infect roots receive less attention than those infecting the aerial parts of crops despite their significant impact on plant growth and fruit production.ResultsWe assembled a 54.9MbP. lycopersicidraft genome sequence based on Illumina short reads, and annotated approximately 17,000 genes. TheP. lycopersicigenome is closely related to hemibiotrophs and necrotrophs, in agreement with the phenotypic characteristics of the fungus and its lifestyle. Several gene families related to host–pathogen interactions are strongly represented, including those responsible for nutrient absorption, the detoxification of fungicides and plant cell wall degradation, the latter confirming that much of the genome is devoted to the pathogenic activity of the fungus. We did not find a MAT gene, which is consistent with the classification ofP. lycopersicias an imperfect fungus, but we observed a significant expansion of the gene families associated with heterokaryon incompatibility (HI).ConclusionsTheP. lycopersicidraft genome sequence provided insight into the molecular and genetic basis of the fungal lifestyle, characterizing previously unknown pathogenic behaviors and defining strategies that allow this asexual fungus to increase genetic diversity and to acquire new pathogenic traits.
Systematic review and meta-analysis of the duration of clinical effect of onabotulinumtoxinA in cervical dystonia
Authors: Marsh Wallace A , Monroe Deirdre M , Brin Mitchell F , Gallagher Conor J 
Published: April 2014

Abstract

Background
Botulinum toxins are considered first-line therapy for treatment of cervical dystonia (CD) and must be injected on a repeat basis. Understanding the duration of clinical benefit of botulinum toxins and its impact on health care utilization are thus important in the contemporary environment. However, there is currently no overall consensus on the duration of effect of onabotulinumtoxinA in the treatment of CD. We performed a systematic review and meta-analysis to identify the duration of effect of onabotulinumtoxinA in CD and investigate factors that may influence it.

Methods
A systematic literature search identified prospective or retrospective studies reporting duration of effect of onabotulinumtoxinA for the treatment of CD. Inclusion criteria included peer-reviewed, non-review, English-language articles published between January 1980 and January 2013. A formal meta-analysis using Comprehensive Meta-Analysis Version 2 was conducted to identify the duration of effect of onabotulinumtoxinA in the treatment of CD; both fixed and random effects models were performed. Subgroup analyses were performed to identify factors that influenced the duration of effect of onabotulinumtoxinA.

Results
A total of 18 studies (including >1,900 patients) met the inclusion criteria and were used for the meta-analysis. The mean duration of effect of onabotulinumtoxinA in CD was found to be 93.2 days (95% CI 91.8-94.6 days) for the fixed effects model and 95.2 days (95% CI 88.9-101.4 days) for the random effects model. A meta-regression found that dose of onabotulinumtoxinA and country of origin influenced the duration of effect of onabotulinumtoxinA, whereas quality score of the article and study type did not. In particular, doses ≥180 Units were associated with longer durations of effect than doses <180 Units (107-109 days vs. 86-88 days, respectively; p < 0.01). Limitations included pooling studies that used discrete definitions of duration and had different designs and study quality.

Conclusions
Based on the published literature, the mean duration of effect of onabotulinumtoxinA in CD was 93-95 days (13.2-13.5 weeks). This suggests that, in general, patients with CD treated with onabotulinumtoxinA should require ~4 treatments per year.
Production of recombinant human annexin V by fed-batch cultivation
Authors: Marder Laura S , Lunardi Juleane , Renard Gaby , Rostirolla Diana C , Petersen Guilherme O , Nunes José E S , de Souza Ana Paula D , de O Dias Ana Christina , Chies Jocelei M , Basso Luiz A , Santos Diógenes S , Bizarro Cristiano V 
Published: April 2014

AbstractBackgroundAnnexin V, a 35.8 kDa intracellular protein, is a Ca+2- dependent phospholipid binding protein with high affinity to phosphatidylserine (PS), which is a well-known hallmark of apoptosis. Annexin V is a sensitive probe for PS exposure upon the cell membrane, and used for detection of apoptotic cells bothin vivoandin vitro. Large-scale production of recombinant human annexin V is worth optimization, because of its wide use in nuclear medicine, radiolabeled with99mTc, for the evaluation of cancer chemotherapy treatments, and its use in identification of apoptotic cells in histologic studies. Here we describe the high-yield production of a tag-free version of human annexin V recombinant protein by linear fed-batch cultivation in a bioreactor.ResultsWe cloned the humanANXA5coding sequence into the pET-30a (+) expression vector and expressed rhANXA5 in batch and fed-batch cultures. UsingE. coliBL21 (DE3) in a semi-defined medium at 37°C, pH 7 in fed-batch cultures, we obtained a 45-fold increase in biomass production, respective to shaker cultivations. We developed a single-step protocol for rhANXA5 purification using a strong anion-exchange column (MonoQ HR16/10). Using these procedures, we obtained 28.5 mg of homogeneous, nontagged and biologically functional human annexin V recombinant protein from 3 g wet weight of bacterial cells from bioreactor cultures. The identity and molecular mass of rhANXA5 was confirmed by mass spectrometry. Moreover, the purified rhANXA5 protein was functionally evaluated in a FITC-annexin V binding experiment and the results demonstrated that rhANXA5 detected apoptotic cells similarly to a commercial kit.ConclusionsWe describe a new fed-batch method to produce recombinant human annexin V in large scale, which may expand the commercial utilities for rhANXAV to applications such asin vivoimaging studies.
Gender and regional disparities of tuberculosis in Hunan, China
Authors: Chen Mengshi , Kwaku Abuaku Benjamin , Chen Youfang , Huang Xin , Tan Hongzhuan , Wen Shi Wu 
Published: April 2014

Abstract

Introduction
Major efforts have been made to improve the health care system in Hunan province, China. The aims of this study were to assess whether and to what extent these efforts have impacted on gender and regional disparities of Tuberculosis (TB) incidence in recent years, especially for less developed areas.

Methods
We obtained data from the 2005–2009 China Information System for Disease Control and Prevention (CISDCP)to conduct this study in Hunan province. Counties within the province were divided into four regions according to quartiles based on the 2007 per capita GDP. Index of Disparity (ID) and Relative Index of Inequality (RII) were used to measure the disparities of TB incidence in relation to gender and region. Bootstrap technique was used to increase the precision.

Results
The average annual incidence of TB was 111.75 per 100,000 in males and 43.44 per 100 000 in females in Hunan. The gender disparity was stable, with ID from 42.34 in 2005 to 43.92 in 2009. For regional disparity, ID, RII (mean) and RII (ratio) decreased significantly from 2005 to 2009 in males (P < 0.05) but remained stable among the female population.

Conclusions
As interventions such as introduction of the New Rural Cooperative Scheme put in place to reduce health disparities in China, regional disparity in relation to incidence of TB decreased significantly, but the gender disparity remains in the Hunan province.
Spontaneous rupture of hepatic metastasis from small cell neuroendocrine carcinoma of maxillary sinus
Authors: Duan Yun-fei , Tan Yan , Yuan Bo , Zhu Feng 
Published: April 2014

Abstract

Background
Small cell neuroendocrine carcinoma of the maxillary sinus, a rare malignant tumor, has a poor prognosis because of its high incidence of metastasis. Moreover, metastatic cancer-induced hepatic rupture, characterized by hemoperitoneum, is infrequent, although several lines of evidences have reported that a wide variety of other neoplasms can cause this usually fatal manifestation.

Case presentation
We now present the first case of a 49-year-old man with spontaneous rupture of hepatic metastasis from small cell neuroendocrine carcinoma of the maxillary sinus and ultimately resulted in massive intraperitoneal bleeding, which was successfully controlled by subsequent surgery (partial hepatectomy). The postoperative clinical manifestation of the patient was uneventful. He was discharged on the 16th day after operation and without any complication.

Conclusions
Small cell neuroendocrine carcinoma of the maxillary sinus is very scarce and unfortunately has a poor prognosis. It has potential to cause spontaneous metastatic rupture which can elicit fatal hemorrhage. Emergency surgery is effective, although the long-term outcome is still unsatisfactory.
Utility-based resource allocation in high-speed railway wireless networks
Authors: Xu Shengfeng , Zhu Gang , Shen Chao , Lei Yan , Zhong Zhangdui 
Published: April 2014

AbstractIn this paper, we investigate the utility-based resource allocation problem at a base station in high-speed railway (HSR) wireless networks, jointly taking into account the power allocation along the time and the packet allocation among services. The problem to maximize the total utility under the average power constraint is formulated as a mixed-integer non-linear programming (MINLP) problem. Through the integer constraint relaxation, the MINLP problem can be simplified into a convex optimization problem. The detailed analysis reveals that the relaxed problem can be equivalently decomposed into power allocation problem along the time and packet allocation problem among services, which can reduce the problem size. When the optimality of the relaxed problem is achieved, the power allocation along the time and the packet allocation along the time for each service are both proportionally fair. Since the integer relaxation causes a non-integer solution not implementable in practice, a greedy algorithm is proposed to obtain a near-optimal integer solution of the MINLP problem. Finally, the performance of the proposed algorithm is analyzed by simulations under realistic conditions for HSR wireless networks.
A simplified evaluation system of surface-related lung lesions of pigs for official meat inspection under industrial slaughter conditions in Germany
Authors: Steinmann Thorsten , Blaha Thomas , Meemken Diana 
Published: April 2014

AbstractBackgroundEuropean and national administrative legislation require objective evaluation systems for organ lesions at pig slaughter. These results can be used as basis for herd health improvement programs by farmers and their consulting veterinarians. Various studies have shown that the current evaluation and recording of lesions by authorized meat inspectors are not reliable and produce significant inter-rater disagreement especially for lung lesions in pigs. The objectives of this study were to increase the usability of official meat inspection data by a developed and validated scheme and to analyze potential improvements in the reliability of the proposed system under industrialized slaughter conditions.ResultsA simplified evaluation scheme for surface-related lung lesions was developed based on morphometric evaluations of unaffected lungs with quantitative relationships of each lobe to the whole lung (“Rule of Tens”). Furthermore, a theoretical as well as a hands-on training program for meat inspectors was developed and applied. Based on 5,183 lungs, the authors established a baseline of the inter-rater reliability of current routine assessments of lung lesions as documented by meat inspectors compared with the assessments of an independent veterinarian using the developed simplified evaluation scheme. Most frequent inter-rater disagreements greater than 75% were found for moderate pneumonia. Sources of the deviations most frequently included misinterpretations of technical artifacts, which were erroneously assessed by the meat inspectors as pneumonic lung lesions. Results of the post-training investigation based on 4,646 lungs showed a significantly improved reliability of lung lesion evaluation and the inter-rater agreement increased in all respects. Especially the disagreement of recording moderate cases of pneumonia decreased in total to 15% deviations from reference.ConclusionsThe presented simplified lung evaluation scheme showed its capability to standardize the evaluation of lung lesions according to administrative legislation under industrialial slaughter conditions. The reliability of official meat inspections can be significantly increased with the help of the presented scheme to assess surface-related lung lesions of slaughter pigs. Continuous standardization and optimization can be achieved by personalized training programs in the framework of quality assurance systems for meat inspectors.
Immediate versus delayed integrated point-of-care-ultrasonography to manage acute dyspnea in the emergency department
Authors: Pirozzi Concetta , Numis Fabio G , Pagano Antonio , Melillo Paolo , Copetti Roberto , Schiraldi Fernando 
Published: April 2014

Abstract

Background
Dyspnea is one of the most frequent complaints in the Emergency Department. Thoracic ultrasound should help to differentiate cardiogenic from non-cardiogenic causes of dyspnea. We evaluated whether the diagnostic accuracy can be improved by adding a point-of-care-ultrasonography (POC-US) to routine exams and if an early use of this technique produces any advantage.

Methods
One hundred sixty-eight patients were enrolled and randomized in two groups: Group 1 received an immediate POC-US in addition to routine laboratory and instrumental tests; group 2 received an ultrasound scan within 1 h from the admission to the Emergency Department. The concordance between initial and final diagnosis and the percentage of wrong diagnosis in the two groups were evaluated. Mortality, days of hospitalization in Emergency Medicine department and transfers to other wards were compared. Sensitivity and specificity of the routine protocol and the one including ultrasonography for the diagnosis of the causes of dyspnea were also analyzed.

Results
Eighty-eight patients were randomized in group 1 and 80 in group 2. The concordance rate between initial and final diagnoses was significantly different (0.94 in group 1 vs. 0.22 in group 2, p < 0.005). The percentage of wrong initial diagnosis was 5% in group 1 and 50% in group 2 (p < 0.0001).

Conclusions
Adding POC-US to routine exams improves the diagnostic accuracy of dyspnea and reduces errors in the Emergency Department.
Psychometric properties of the Polish version of the Body Attitude Test
Authors: Brytek-Matera Anna , Probst Michel 
Published: May 2014

Aim of the studyPolish studies have not been focused on measures which assess attitude toward one’s own body. The purpose of the study was to develop the Polish version of the Body Attitude Test (BAT) and examine its reliability.Subject or material and methodsThe study included 48 patients with anorexia nervosa, 39 patients with bulimia nervosa as well as 115 female university students. The mean age was 18.69 years (SD = 3.52) in women with anorexia, 22.28 years (SD = 3.79) in women with bulimia as well as 20.53 years (SD = 1.79) in women without a current eating disorder. The mean duration of illness was 3.31 years (SD = 2.71) in patients with anorexia and 5.10 years (SD = 2.92) in patients with bulimia, respectively.ResultsThe BAT demonstrates satisfactory levels of internal reliability (α = .892). The BAT was strongly related with the Eating Disorder Inventory subscales: drive for thinness (r = .687, p < .001), ineffectiveness (r=.643, p<.001) and body dissatisfaction (r=.634, p<.001) and the Self-Esteem Inventory subscale: familial self-esteem (r=-.601, p<.001). Women with eating disorders presented more negative body experience than women without a current eating disorder. In addition, patients with bulimia had more negative appreciation of their body size in comparison with patients with anorexia.DiscussionThe results support the criterion validity of the BAT which is able to differentiate clinical from non-clinical subjects.ConclusionsThe Polish version of the BAT could be used as an appropriate measure assessing subjective attitude towards the body in women with and without eating disorders in Poland.
An International Termite Field Test of Wood Treated with Insecticides in a Buffered Amine Oxide Carrier
Authors: Morris Paul Ian , Grace J. Kenneth , Yoshimura Tsuyoshi , Tsunoda Kunio 
Published: April 2014

Abstract
A buffered amine oxide carrier has shown promise to deeply penetrate dry lumber with insecticides for termite control without using pressure treatment. Pine sapwood from trees attacked by mountain pine beetle (MPB) has increased permeability. In this study, short lengths of heavily blue stained, post-MPB lodgepole pine lumber (Pinus contorta) were treated with the buffered amine oxide carrier to borate levels less than the retentions recommended for protection against attack by the Formosan subterranean termite (average, 0.5% mass/mass boric acid equivalent ), with and without the addition of organic insecticides. Additional samples were pressure treated with alkaline copper quaternary type D carbonate (ACQ-D) and disodium octaborate tetrahydrate (DOT). The boards were installed in field tests in Hawaii and Japan at sites with confirmed populations of Formosan subterranean termites. They were inspected after 2 and 5 years. Dip plus kiln-conditioning treatment with imidacloprid, permethrin plus imidacloprid, and permethrin provided good protection to post-MPB lodgepole pine lumber against termite attack over 5 years in Hawaii and Japan. Dip plus kiln-conditioning treatment with the buffered amine oxide alone provided no protection because of the low loading of borate used as the buffer. Samples that were DOT pressure treated to below the retention required for Formosan termites in American Wood Protection Association standards did not perform as well, possibly as a result of poor heartwood penetration as well as below-standard retentions. Addition of permethrin to DOT pressure treatment improved performance. ACQ pressure-treated samples did not perform as well, with two failures in Hawaii. This was also likely associated with poor penetration in the heartwood because this material was not incised.
Being Spike Jonze: Intertextuality and convergence in film, music video and advertising
Authors: Annesley James 
Published: April 2014

Abstract
For many, the films of Spike Jonze are metafictional works that rearticulate established postmodernist debates about ontology and identity. This article rejects these views and suggests that Jonze’s interest in metaphysical play is better explained as an engagement with the blurred boundaries of an increasingly convergent culture. Considering his advertisements and music videos alongside Being John Malkovich (Jonze, 1999) and Adaptation (Jonze, 2002) and reflecting upon the thematic and stylistic continuities that link them all together, the suggestion is that for Jonze these different practices can be read as parts of a creative whole. Made in a common production context, using a shared genepool of production staff and talent, and financed by media companies that are themselves continually merging and hybridizing, Jonze’s stories about celebrity and cinema do not just open ‘a metaphysical can of worms’, but speak more broadly about an environment in which the distinctions between the film business and other parts of the media are increasingly meaningless. The implication is that in narratives preoccupied with the ways in which supposedly different terrains bleed into each other, Jonze’s films, music videos and commercials offer a self-conscious vision of the intertextuality of the contemporary mediascape.