bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation between Association of Psoriasis and Vitiligo
Authors: Yazdanpanah Mohammad Javad , Banihashemi Mahnaz , Pezeshkpoor Fakhrozaman , Moradifar Mehri , Feli Shahab , Esmaeili Habibollah 
Published: March 2015

Background Although the occurrence of psoriasis and vitiligo is reported in a few studies, no proper relationship has been found between these two diseases. Objective The aim of this study was to identify the frequency of the coincidence of these two diseases. Method A descriptive and cross-sectional study was conducted on 6,200 patients referred to dermatology clinics from September 2004 to June 2005. Results Among these patients, 219 and 154 patients suffered from psoriasis (3.53%) and vitiligo (2.48%), respectively, and 12 patients (0.19%) had psoriasis and vitiligo simultaneously. The coincidence in the psoriasis group was 5.48% and in the vitiligo group was 7.79%, so the coincidence of both diseases was greater than the incidence of each alone. This association was significant ( p = .004). Conclusion Coincidence of these two diseases was seen, but more studies should be done to find common genetic and immunologic factors.
POEMS Syndrome Complicated by Extensive Calciphylaxis: A Remarkable Recovery
Authors: Bourgeault Emilie , Dahl Alice , Thibeault Marie-Marthe , Dupéré Audrey , Drolet Anne-Marie , Mathieu Jean 
Published: March 2015

Background and Objective Calciphylaxis is life threatening. It has traditionally been associated with end-stage renal disease and hyperparathyroidism but is increasingly common in other clinical contexts. The association of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome and calciphylaxis has been reported only in a few cases. This case is the first of patient survival in such widespread disease. Methods and Results A 42-year-old man with POEMS syndrome developed extensive calciphylaxis despite normal renal and parathyroid function. Rapid diagnosis, treatment, and supportive care contributed to full clinical resolution. Conclusion This is the fifth case of POEMS syndrome associated with calciphylaxis. The observations from this report suggest that POEMS syndrome might be an independent risk factor for the development of calciphylaxis. This case underlines the importance of careful follow-up in patients with POEMS syndrome and prompt diagnosis and treatment of associated calciphylaxis.
Pigmented Mammary Paget Disease Mimicking Superficial Spreading Melanoma in an Elderly African-American Female
Authors: Napolitano Larry , Crowe David 
Published: March 2015

Background Pigmented mammary Paget disease (PMPD) is a rare disease that may mimic cutaneous melanoma both in clinical presentation and on histology. Objective The goal of this study was to discuss the clinical and histologic similarities between PMPD and cutaneous melanoma and how to differentiate between the two diseases. Methods We describe an African-American patient with PMPD who was thought to have cutaneous melanoma on presentation. We describe the similarities of PMPD to cutaneous melanoma both clinically and on histology and discuss the methods of differentiation. Results Clinical examination revealed a large pigmented patch of the left breast that appeared asymmetrical with irregular borders with a highly variable color pattern throughout. Histologic evaluation showed characteristics shared between PMPD and cutaneous melanoma. Immunohistochemical staining was needed for differentiation. Conclusion PMPD is a rare disease and is similar in clinical presentation and on histology to cutaneous melanoma. Immunohistochemical staining must be used to differentiate between the two diseases.
Multiple Cutaneous Creamy Papules and Nodules: A Case of Miliarial Gout
Authors: Kirchhof Mark G. , Collins David , Crawford Richard I. , Au Sheila 
Published: March 2015

Background Tophaceous gout is the nonarticular deposition of monosodium urate resulting from a disorder in purine metabolism that causes an elevation of serum uric acid. Cutaneous variants of tophaceous gout include papular, nodular, ulcerative, and pustular forms. Objective We present a case of a 67-year-old man who presented with multiple cutaneous creamy white papules and nodules. A biopsy was taken, and a diagnosis of cutaneous tophaceous gout was made. The treatment and pathophysiology are discussed. Conclusion Miliarial gout is a rare form of cutaneous tophaceous gout that is treated using xanthine oxidase inhibitors such as allopurinol and febuxostat or uricosurics such as probenecid.
Generalized Multinucleate Cell Angiohistiocytoma
Authors: Doane Jennifer A.E. , Purdy Kerri , Pasternak Sylvia 
Published: March 2015

Background There are less than 100 cases of multinucleate cell angiohistiocytoma (MCA) currently reported in the literature. It occurs as a localized, asymptomatic, benign proliferation of the skin, characterized histologically by irregular multinucleate cells. Due to its novelty, the etiology of the disease and treatment options are still under investigation. Objective To report a case of confirmed, generalized MCA along with a review of the literature on the histology, immunology, potential etiology, and treatment of MCA. Observations The patient was a 41-year-old female with asymptomatic violaceous plaques found on the extensor arms, legs, and trunk. Histopathology revealed increased dilated vascularity and cellularity (composed of mononuclear histiocytes and a few angulated multinucleated giant cells) in the dermis. Conclusions Overall, MCA is a poorly understood, distinct dermatologic phenomenon. Here we present a case of generalized MCA to further the understanding of this disease presentation.
Treatment effects produced by the Twin-block appliance vs the Forsus Fatigue Resistant Device in growing Class II patients
Authors: Giuntini Veronica , Vangelisti Andrea , Masucci Caterina , Defraia Efisio , McNamara Jr James A. , Franchi Lorenzo 
Published: March 2015

ABSTRACT

Objective:
To compare the dentoskeletal changes produced by the Twin-block appliance (TB) followed by fixed appliances vs the Forsus Fatigue Resistant Device (FRD) in combination with fixed appliances in growing patients having Class II division 1 malocclusion.

Materials and Methods:
Twenty-eight Class II patients (19 females and 9 males; mean age, 12.4 years) treated consecutively with the TB followed by fixed appliances were compared with a group of 36 patients (16 females and 20 males; mean age, 12.3 years) treated consecutively with the FRD in combination with fixed appliances and with a sample of 27 subjects having untreated Class II malocclusion (13 females and 14 males; mean age, 12.2 years). Mean observation interval was 2.3 years in all groups. Cephalometric changes were compared among the three groups by means of ANOVA and Tukey's post hoc tests.

Results:
The FRD produced a significant restraint of the maxilla compared with the TB and control samples (SNA, −1.1° and −1.8°, respectively). The TB sample exhibited significantly greater mandibular advancement and greater increments in total mandibular length than either the FRD or control groups (SNB, 1.9° and 1.5°, respectively; and Co-Gn, 2.0 mm and 3.4 mm, respectively). The FRD produced a significantly greater amount of proclination of the mandibular incisors than what occurred with the TB or the control samples (2.9° and 5.6°, respectively).

Conclusion:
The TB appliance produced greater skeletal effects in terms of mandibular advancement and growth stimulation while the Forsus caused significant proclination of the mandibular incisors.
Circulating and Dietary Trans Fatty Acids and Incident Type 2 Diabetes in Older Adults: The Cardiovascular Health Study
Authors: Wang Qianyi , Imamura Fumiaki , Ma Wenjie , Wang Molin , Lemaitre Rozenn N. , King Irena B. , Song Xiaoling , Biggs Mary L. , Delaney Joseph A. , Mukamal Kenneth J. , Djousse Luc , Siscovick David S. , Mozaffarian Dariush 
Published: March 2015

OBJECTIVE
To investigate the effects of trans fatty acids (TFAs) on type 2 diabetes mellitus (DM) by specific TFA subtype or method of assessment.

RESEARCH DESIGN AND METHODS
In the Cardiovascular Health Study, plasma phospholipid trans (t)-16:1n9, t-18:1, and cis (c)/t-, t/c-, and t/t-18:2 were measured in blood drawn from 2,919 adults aged 74 ± 5 years and free of prevalent DM in 1992. Dietary TFA was estimated among 4,207 adults free of prevalent DM when dietary questionnaires were initially administered in 1989 or 1996. Incident DM was defined through 2010 by medication use or blood glucose levels. Risks were assessed by Cox proportional hazards.

RESULTS
In biomarker analyses, 287 DM cases occurred during 30,825 person-years. Both t-16:1n9 (extreme quartile hazard ratio 1.59 [95% CI 1.04–2.42], P-trend = 0.04) and t-18:1 (1.91 [1.20–3.03], P-trend = 0.01) levels were associated with higher incident DM after adjustment for de novo lipogenesis fatty acids. In dietary analyses, 407 DM cases occurred during 50,105 person-years. Incident DM was positively associated with consumption of total TFAs (1.38 [1.03–1.86], P-trend = 0.02), t-18:1 (1.32 [1.00–1.76], P-trend = 0.04), and t-18:2 (1.41 [1.05–1.89], P-trend = 0.02). After further adjustment for other dietary habits, however, the associations of estimated dietary TFA with DM were attenuated, and only nonsignificant positive trends remained.

CONCLUSIONS
Among older adults, plasma phospholipid t-16:1n9 and t-18:1 levels were positively related to DM after adjustment for de novo lipogenesis fatty acids. Estimated dietary TFA was not significantly associated with DM. These findings highlight the need for further observational, interventional, and experimental studies of the effects TFA on DM.
Comparison of Glycemic and Metabolic Control in Youth With Type 1 Diabetes With and Without Antipsychotic Medication: Analysis From the Nationwide German/Austrian Diabetes Survey (DPV)
Authors: Galler Angela , Bollow Esther , Meusers Michael , Bartus Bela , Näke Andrea , Haberland Holger , Schober Edith , Holl Reinhard W. 
Published: March 2015

OBJECTIVEThe objective of this study was to explore metabolic risk factors and glycemic control in youth with type 1 diabetes treated with typical or atypical antipsychotics.RESEARCH DESIGN AND METHODSData for 60,162 subjects with type 1 diabetes up to the age of 25 years registered in the nationwide German/Austrian Diabetes Survey were included in the analysis. BMI; HbA1c; treatment strategy; prevalence of hypertension, dyslipidemia, microalbuminuria, and retinopathy; frequency of hypoglycemia and diabetic ketoacidosis (DKA); and immigrant status among subjects treated with typical or atypical antipsychotics were compared with those without antipsychotic medication and analyzed by regression analysis.RESULTSA total of 291 subjects with type 1 diabetes (median diabetes duration 7.2 years) received antipsychotic medications (most commonly risperidone). Subjects treated with antipsychotics had a higher BMI (P = 0.004) and dyslipidemia was more frequent (P = 0.045) compared with subjects not receiving antipsychotic medication. Frequencies of severe hypoglycemia and DKA were significantly higher in subjects receiving antipsychotics (P &lt; 0.001). The prevalences of hypertension, microalbuminuria, and retinopathy were not different. In subjects treated with typical antipsychotics, glycemic control did not differ compared with those who did not receive antipsychotic medications. By contrast, subjects treated with atypical antipsychotics had higher HbA1c levels (P = 0.022).CONCLUSIONSThis analysis from a real-life survey demonstrated that subjects with antipsychotic medication had worse glycemic control and a higher rate of acute complications compared with those without antipsychotic medication. Health care teams caring for youth with type 1 diabetes taking antipsychotic medication need to know about these findings. We suggest monitoring metabolic risk factors as well as providing diabetes education about prevention of acute complications.
Association Between Cardiorespiratory Fitness and the Determinants of Glycemic Control Across the Entire Glucose Tolerance Continuum
Authors: Solomon Thomas P.J. , Malin Steven K. , Karstoft Kristian , Knudsen Sine H. , Haus Jacob M. , Laye Matthew J. , Kirwan John P. 
Published: March 2015

OBJECTIVE
Cardiorespiratory fitness (VO2max) is associated with glycemic control, yet the relationship between VO2max and the underlying determinants of glycemic control is less clear. Our aim was to determine whether VO2max is associated with insulin sensitivity, insulin secretion, and the disposition index, a measure of compensatory pancreatic β-cell insulin secretion relative to insulin sensitivity, in subjects representing the entire range of the glucose tolerance continuum.

RESEARCH DESIGN AND METHODS
A cohort of subjects (N = 313) with heterogeneous age, sex, BMI, and glycemic control underwent measurements of body composition, HbA1c, fasting glucose, oral glucose tolerance (OGTT), and VO2max. OGTT-derived insulin sensitivity (SiOGTT), glucose-stimulated insulin secretion (GSISOGTT), and the disposition index (DIOGTT) (the product of SiOGTT and GSISOGTT) were measured, and associations between VO2max and these determinants of glycemic control were examined.

RESULTS
A low VO2max was associated with high HbA1c (r = −0.33), high fasting glucose (r = −0.34), high 2-h OGTT glucose (r = −0.33), low SiOGTT (r = 0.73), and high early-phase (r = −0.34) and late-phase (r = −0.36) GSISOGTT. Furthermore, a low VO2max was associated with low early- and late-phase DIOGTT (both r = 0.41). Interestingly, relationships between VO2max and either glycemic control or late-phase GSISOGTT deteriorated across the glucose tolerance continuum.

CONCLUSIONS
The association between poor cardiorespiratory fitness and compromised pancreatic β-cell compensation across the entire glucose tolerance continuum provides additional evidence highlighting the importance of fitness in protection against the onset of a fundamental pathophysiological event that leads to type 2 diabetes.
A Risk Metric Assessment of Scenario-Based Market Risk Measures for Volatility and Risk Estimation: Evidence from Emerging Markets
Authors: Sitima Innocent , Hlatywayo Clifford K. 
Published: March 2015

Abstract
The study evaluated the sensitivity of the Value- at- Risk (VaR) and Expected Shortfalls (ES) with respect to portfolio allocation in emerging markets with an index portfolio of a developed market. This study utilised different models for VaR and ES techniques using various scenario-based models such as Covariance Methods, Historical Simulation and the GARCH (1, 1) for the predictive ability of these models in both relatively stable market conditions and extreme market conditions. The results showed that Expected Shortfall has less risk tolerance than VaR based on the same scenario-based market risk measures
Histamine Downregulates Aquaporin 5 in Human Nasal Epithelial Cells
Authors: Wang Weiwei , Wang Xiaolian , Ma Lan , Zhang Ruitao 
Published: March 2015

Background Aquaporin 5 (AQP5) is a water-specific channel protein. It is thought to be a key participant in fluid secretion and a rate-limiting barrier to the secretion seen during allergic inflammation. We sought to determine the effect of histamine on AQP5 expression in human nasal epithelial cells (HNEpC). Methods HNEpC cells were cultured with four concentrations of histamine in vitro. The phosphorylation of cyclic adenosine monophosphate-responsive element binding protein (CREB) at serine 133 and the AQP5 protein were measured by using immunocytochemistry and Western blotting. Real-time polymerase chain reaction was used to detect AQP5 messenger ribonucleic acid (mRNA). Results Concentration-dependent histamine induced-inhibition of CREB phosphorylation at serine 133 in HNEpC cells was observed, and AQP5 mRNA and protein were also downregulated in a concentration-dependent fashion. Conclusion Histamine downregulates AQP5 production in HNEpC cells by inhibiting CREB phosphorylation at serine 133.
Evaluation of Polymer Flooding Potential Based on Orthogonal Design and BP Artificial Neural Network
Authors: Wang Yanbin , Hou Jian , Cao Xulong , Wu Guanghuan , Wang Chuanfei 
Published: March 2015

Abstract
This paper has proposed a novel approach for evaluation of polymer flooding potential during oil reservoir development, which has integrated orthogonal design and BP artificial network.
This paper firstly divides the evaluated polymer flooding reservoir units into four styles using Weighted Euclidean Distance method. On the basic of unit sorting, we have generated predictive samples sets for polymer flooding potential with orthogonal design and reservoir simulation. In order to enhance the reliability and prediction ability of the polymer flooding network models, this paper has created a new orthogonal experiment design table to meet this study. It can cover the evaluated reservoir blocks but improve the extendibility of the network by enhancing training sample numbers. After that, Enhanced Oil Recovery(EOR) and Internal Rate of Return(IRR) predictive models of polymer flooding are constructed using BP artificial neural network method. At last, the paper has introduced two new concepts of applicability degree and risk degree to assess reservoir conditions for polymer flooding and implementation risk.
Taking technical, economic and risk factors into account, comprehensive potential evaluation was carried out with the predictive models of polymer flooding potential for part of reservoir blocks in Shengli oilfield in China.
The evaluation results have shown that the predictive models are of higher accuracy and better extendibility, which can satisfy the demands of engineering computation application.

Introduction
Polymer flooding has become one of the main enhanced oil recovery methods for inshore oilfields in China. At present, enhanced oil recovery techniques such as polymer flooding and chemical combination flooding, have been widely implemented in Daqing oilfield and Shengli oilfield in China and obtained great economic and social benefits (Chang et al., 2006; Sun,2006). But as a kind of tertiary recovery method for polymer flooding itself, there must be some certain risk for its field implementation owing to intricate reservoir conditions and high cost of chemical agent. And yet, under the situation of high international oil price, were the polymer flooding applied rationally and appropriately, it would still be able to gain better economic benefits. Therefore, it is very necessary to carry out the evaluation of polymer flooding potential including technical, economic and risk aspects so as to supply guidance for polymer flooding application to reduce investment risk and enhance economic benefits.
How Malfunctioning Completion Accessories Affect Well Performance Offshore Saudi Arabia
Authors: Al-Khanferi Mohammed Tariq , Bubshait Ahmed Khalid , Abd El-Fattah Mahmoud Mohamed , Al-Shabibi Hussain , Bawazir Mustafa Abdulrahman 
Published: March 2015

Abstract
To overcome horizontal well reservoir and production challenges, inflow control devices are adopted as the optimal completion method in many parts of the world. The main industry drivers for adopting inflow control device completions include balancing inflow along the well, delaying water and gas breakthrough, controlling water and sand production, and providing a cost-effective reservoir completion solution to meet the majority of the reservoir challenges. In offshore Saudi Arabia, inflow control devices have been used successfully in fulfilling these objectives. The downhole completion efficiency is evaluated using multiphase production logging tools.
Many completion accessories can be run with inflow control device completion strings, these include isolation packers, liner hangers, setting tools, end-of-completion string plugs and valves. All of these accessories may affect the well's production performance. New challenges arise when one of these accessories, such as the end-of-completion valve or isolating packers malfunction and develop a leak; thus, affecting the inflow control device completion performance. A major failure can result from such a malfunction, including fluid drainage from the toe section, sand production, early water breakthrough and water coning.
This paper presents two field examples in which multiphase production logging profiles of horizontal wells are used to evaluate the inflow control device completion performance and detect any completion-accessory malfunction. Multiple sensitivity simulation runs — supported by multiphase production logging results — facilitate optimizing the inflow control device completed well performance. This integrated approach is used to recommend solutions or remedial actions to overcome sub-optimal well completion performance. Also, the approach provides a comprehensive understanding of the reservoir results that should be considered in planning future completion and workover strategies.

Introduction
Hydrocarbon demands continue to drive production, particularly among assets in offshore reservoirs. Horizontal wells produce fluids by nonuniform inflow due to reservoir permeability/pressure variations along laterals, frictional effects along the wellbore, and sand production. The nonuniform inflow promotes early water/gas breakthrough. These wells are completed using inflow control devices (ICDs) with screens to optimize the well performance and overcome the main field challenges, namely formation damage during drilling by better cleanup processes, pressure loss due to heel-to-toe friction, and sand control.
Geomechanical Evaluation Enabled Successful Stimulation of a HPHT Tight Gas Reservoir in Western China
Authors: Zhang Hui , Qiu Kaibin , Fuller John , Yin Guoqing , Yuan Fang , Chen Sheng 
Published: March 2015

Keshen reservoir is a deep, tight gas sandstone reservoir under high tectonic stress with reservoir pressure over 16,000 psi (110 MPa) and temperatures up to 165 °C. Development wells for this field are in excess of 6500m in true vertical depth. Stimulation is required to provide production rates that compensate for the high cost of drilling and completing wells. Hydraulic fracture design and execution must be optimal to ensure economic production.To effectively stimulate a more than 200 m thick sandstone reservoir with consistently high performance, it is necessary to understand the mechanical behaviour of the reservoir, especially mechanical properties and in-situ stresses as the two control initiation and propagation of each hydraulic fracture. The mechanical behaviour is complicated by high tectonic stresses, significant compaction, and high overpressure.To gain an in-depth understanding of the mechanical properties and in-situ stresses of Keshen reservoir, an integrated geomechanical evaluation was conducted. The evaluation used core from two wells, KS205 and KS207, and log data obtained from 15 wells including the wells with core evaluation in the field. A laboratory testing program to investigate the mechanical behavior of the reservoir sandstone under realistic in-situ stresses, pore pressures, and temperature was performed. The description of mechanical behavior obtained from the laboratory testing was used to calibrate and augment mechanical earth models (MEMs) constructed from well log data. The reliability of the completed MEMs was validated through comparison between wellbore stability predictions with observation of borehole failure from the borehole microresistivity image.The geomechanics information was delivered to the stimulation engineering team. Hydraulic fracture design and execution was conducted based on this information. The outcome of hydraulic fracturing was very encouraging.This study demonstrated that successful stimulation of tight reservoir in high pressure, high temperature relies on integrated geomechanical analysis.