bluuebunny/crossref_metadata_2025_split huggingface dataset:
Industry of employment and occupational class in relation to cardiovascular health by race/ethnicity, sex/gender, age and income among adults in the USA: a cross-sectional study
Authors: Murkey Jamie A , Gaston Symielle A , Alhasan Dana M , Jackson W Braxton , Jackson Chandra L 
Published: July 2024

BackgroundRacially minoritised groups tend to have poorer cardiovascular health (CVH) than non-Hispanic (NH)-White adults and are generally more likely to work in labourer or support service positions where job strain—associated with cardiovascular disease—is often high. Yet, few studies have included racially/ethnically diverse samples.MethodsUsing 2004–2018 National Health Interview Survey cross-sectional data, we investigated standardised occupational classifications in relation to ‘ideal’ CVH using a modified ‘ideal’ CVH (mICVH) metric among US adults (n=230 196) by race/ethnicity, sex/gender, age, and income. mICVH was defined as a report of ‘yes’ to the following: never smoked/former smoker; body mass index (≥18.5–25 kg/m2); physical activity (≥150–300 min/week moderate or ≥75–150 min/week vigorous); sleep duration (7–9 hours/night); and no prior diagnosis of dyslipidaemia, hypertension, or diabetes/pre-diabetes. Adjusting for sociodemographic, clinical factors, and health behaviour confounders, we used Poisson regression with robust variance to estimate prevalence ratios (PRs) and 95% CIs of mICVH overall and by race/ethnicity and performed Wald tests for interaction.ResultsLatinx (53%) and NH-Black (37%) adults were more likely than NH-White adults (29%) to report labourer positions and had the lowest prevalence of mICVH (5.2% (Latinx) and 3.9% (NH-Black)). Labourer versus professional/management occupational class positions were associated with a lower mICVH prevalence among NH-Asian (PR=0.60 (0.46–0.79)), NH-White (PR=0.80 (0.74–0.87)) and NH-Black (PR=0.77 (0.58–1.01)), but with no evidence of an association among Latinx (PR=0.94 (0.78–1.14) adults; p interaction <0.001).ConclusionsIn conclusion, working in labourer versus professional/management positions was associated with lower mICVH, except among Latinx adults. Given the higher likelihood of labourer occupations and lower prevalence of mICVH among minoritised racial/ethnic groups, social determinants related to occupational class should be considered in future studies of racial and ethnic disparities in CVH.
Decoding behaviour change techniques in opioid deprescribing strategies following major surgery: a systematic review of interventions to reduce postoperative opioid use
Authors: Bansal Neetu , Armitage Christopher J , Hawkes Rhiannon E , Tinsley Sarah , Ashcroft Darren M , Chen Li-Chia 
Published: July 2024

Background and objectivesMethodsA structured search strategy encompassing databases including MEDLINE, Embase, CINAHL Plus, PsycINFO and Cochrane Library was implemented from inception to October 2023. Included studies focused on interventions targeting opioid reduction in adults following major surgeries. The risk of bias was evaluated using Cochrane risk-of-bias tool V.2 (RoB 2) and non-randomised studies of interventions (ROBINS-I) tools, and Cohen’sdeffect sizes were calculated. BCTs were identified using a validated taxonomy.Results22 studies, comprising 7 clinical trials and 15 cohort studies, were included, with varying risks of bias. Educational (n=12), guideline-focused (n=3), multifaceted (n=5) and pharmacist-led (n=2) interventions demonstrated diverse effect sizes (small-medium n=10, large n=12). A total of 23 unique BCTs were identified across studies, occurring 140 times. No significant association was observed between the number of BCTs and effect size, and interventions with large effect sizes predominantly targeted healthcare professionals. Key BCTs in interventions with the largest effect sizes included behaviour instructions, behaviour substitution, goal setting (outcome), social support (practical), social support (unspecified), pharmacological support, prompts/cues, feedback on behaviour, environmental modification, graded tasks, outcome goal review, health consequences information, action planning, social comparison, credible source, outcome feedback and social reward.ConclusionsUnderstanding the dominant BCTs in highly effective interventions provides valuable insights for future opioid tapering strategy implementations. Further research and validation are necessary to establish associations between BCTs and effectiveness, considering additional influencing factors.PROSPERO registration numberCRD42022290060.
Back to Bernoulli: a simple formula for trans-stenotic pressure gradients and retrospective estimation of flow rates in cerebral venous disease
Authors: Sidora Gurnish , Haley Anna L , Cancelliere Nicole M , Pereira Vitor M , Steinman David A 
Published: July 2024

BackgroundVenous sinus stenosis can be associated with cerebrovascular disorders. Understanding the role of blood flow disturbances in these disorders is often hampered by the lack of patient-specific flow rates. Our goal was to demonstrate the impact of this by predicting individual flow rates retrospectively from routine manometry and angiography.MethodsTen cases, spanning a range of stenosis severities and pressure gradients, were selected from a cohort of patients who had undergone venous stenting for pulsatile tinnitus. Lumen geometries were digitally segmented from CT venograms. A simplified Bernoulli formula was derived to estimate individual cycle-average flow rates from clinical pressure gradients and minimum lumen cross-section areas. High-fidelity pulsatile computational fluid dynamics (CFD) simulations were performed to compare predictions of flow disturbances using generic versus individual flow rates, and to validate the Bernoulli formula.ResultsIndividual flow rates derived from the Bernoulli formula deviated by up to 47% from the assumed generic flow rate, resulting in substantial differences in CFD predictions of post-stenotic flow instabilities. Pressure gradients estimated by the simplified Bernoulli formula were, however, highly predictive of pressure gradients from the full CFD simulations (R2=0.95; slope=0.98, 95% CI 0.88 to 1.09).ConclusionsA simple Bernoulli formula can predict CFD-estimated trans-stenotic pressure gradients in realistic venous geometries. As demonstrated here, this may be used to recover individual flow rates from routine-but-invasive clinical measurements; however, it also suggests a simpler path towards non-invasive estimation of trans-stenotic pressure gradients that may avoid some of the challenges associated with 4D flow MRI approaches.
Impact of disease activity patterns on health-related quality of life (HRQoL) in patients with systemic lupus erythematosus (SLE)
Authors: Elefante Elena , Gualtieri Luca , Schilirò Davide , Stagnaro Chiara , Signorini Viola , Zucchi Dina , Cardelli Chiara , Carli Linda , Ferro Francesco , Tani Chiara , Mosca Marta 
Published: July 2024

ObjectiveTo assess the impact of different disease activity patterns—long quiescent (LQ), chronically active (CA) and relapsing-remitting (RR)—on health-related quality of life (HRQoL) in a cohort of patients with systemic lupus erythematosus (SLE).MethodsA retrospective, monocentric analysis of prospectively collected data. Adult SLE outpatients were enrolled between 2017 and 2021.For each year of follow-up, three disease activity patterns were defined: LQ if at each visit clinical Safety of Estrogens in Lupus Erythematosus National Assessment-Systemic Lupus Activity Index (SELENA-SLEDAI)=0, Physician Global Assessment (PGA)=0; CA if at each visit clinical SELENA-SLEDAI >0, PGA >0; RR if patients presented active disease in at least one visit during the observation period, interspersed with periods of remission. These patterns were applied to the year and the 3 years before enrolment.At enrolment, each patient completed: Short Form 36 (SF-36), Lupus Impact Tracker, Functional Assessment of Chronic Illness Therapy (FACIT), Hospital Anxiety and Depression Scale (HADS). The correlation between disease patterns and Patient-Reported Outcomes was analysed.Results241 SLE patients were enrolled, of which 222 had complete clinical data for the 3-year period before enrolment. Both in the year and during the 3 years before enrolment, the most frequent disease pattern was the LQ (154/241 and 122/222 patients, respectively), followed by RR (53/241 and 92/222 patients, respectively) and CA (34/241 and 8/222 patients, respectively).At baseline, fibromyalgia, organ damage, age and daily glucocorticoid dose were associated with worse HRQoL.At the multivariable analysis, after adjusting for confounding factors, patients with LQ disease during the 3 years before enrolment presented a better physical HRQoL (SF-36 physical component summary, regression coefficient=3.2, 95% CI 0.51–5.89, p=0.02) and minor depressive symptoms (HADS-D, regression coefficient=−1.17, 95% CI −2.38 to 0.0.27, p=0.055), compared with patients with CA/RR disease.ConclusionA persistently quiescent disease may have a positive impact on patients’ physical HRQoL and on depressive symptoms. However, this condition appears insufficient to obtain a significant improvement in mental health, fatigue and disease burden among patients with SLE.
Learning From Established Writers
Authors: Yaffe Philip 
Published: July 2024

Each "Communication Corner" essay is self-contained; however, they build on each other. For best results, before reading this essay and doing the exercise, go to the first essay "How an Ugly Duckling Became a Swan," then read each succeeding essay.
It is almost cliché to say that to be a good writer (or good speaker), you should read (or listen to) good writers and speakers. This is true. However, it must be taken with a grain of salt because being too attentive to how others write and speak can lead you into dangerous territory.
The Impact of COVID‐19 Infection on Abdominal Aortic Aneurysms: Mechanisms and Clinical Implications
Authors: Cao Zenghan , Gao Jianhang , Wu Jianqiang , Zheng Yuehong 
Published: July 2024

Background: The COVID‐19 virus not only has significant pathogenicity but also influences the progression of many diseases, altering patient prognosis. Cardiovascular diseases, particularly aortic aneurysms, are among the most life‐threatening conditions.Main Idea: COVID‐19 infection is reported to accelerate the progression of abdominal aortic aneurysms (AAAs) and increase the risk of rupture; however, a comprehensive understanding of the underlying mechanisms remains elusive. This article primarily reviews the relevant foundational research, focusing on disruptions in the renin‐angiotensin‐aldosterone system (RAAS), immune system activation, and coagulation disorders. Furthermore, we summarize related clinical research, including the epidemiology of aortic aneurysms during the pandemic and specific case studies.Conclusion: COVID‐19 infection can influence the onset and progression of aortic aneurysms by affecting the RAAS, triggering inflammation and immune dysregulation in the arterial wall, and inducing a hypercoagulation state. It is crucial to comprehensively understand the impact of pandemic viral infections on aortic diseases at the foundational and clinical levels, thereby identifying potential preventative or therapeutic approaches and preparing for potential future outbreaks.
Random Forests’ Postprocessing Capability of Enhancing Predictive Skill on Subseasonal Time Scales—A Flow-Dependent View on Central European Winter Weather
Authors: Kiefer Selina M. , Lerch Sebastian , Ludwig Patrick , Pinto Joaquim G. 
Published: July 2024

Abstract
Weather predictions 2–4 weeks in advance, called the subseasonal time scale, are highly relevant for socioeconomic decision-makers. Unfortunately, the skill of numerical weather prediction models at this time scale is generally low. Here, we use probabilistic random forest (RF)-based machine learning models to postprocess the subseasonal to seasonal (S2S) reforecasts of the European Centre for Medium-Range Weather Forecasts (ECMWF). We show that these models are able to improve the forecasts slightly in a 20-winter mean at lead times of 14, 21, and 28 days for wintertime central European mean 2-m temperatures compared to the lead-time-dependent mean bias-corrected ECMWF’s S2S reforecasts and RF-based models using only reanalysis data as input. Predictions of the occurrence of cold wave days are improved at lead times of 21 and 28 days. Thereby, forecasts of continuous temperatures show a better skill than forecasts of binary occurrences of cold wave days. Furthermore, we analyze if the skill depends on the large-scale flow configuration of the atmosphere at initialization, as represented by weather regimes (WRs). We find that the WR at the start of the forecast influences the skill and its evolution across lead times. These results can be used to assess the conditional improvement of forecasts initialized during one WR in comparison to forecasts initialized during another WR.

Significance Statement
Forecasts of winter temperatures and cold waves 2–4 weeks in advance done by numerical weather prediction (NWP) models are often unsatisfactory due to the chaotic characteristics of the atmosphere and limited predictive skill at this time range. Here, we use statistical methods, belonging to the so-called machine learning (ML) models, to improve forecast quality by postprocessing predictions of a state-of-the-art NWP model. We compare the forecasts of the NWP and ML models considering different weather regimes (WRs), which represent the large-scale atmospheric circulation such as the typical westerly winds in Europe. We find that the ML models generally yield better temperature forecasts for 14, 21, and 28 days in advance and better forecasts of cold wave days 21 and 28 days in advance. The quality of forecasts depends on the WR present at the forecast start. This information can be used to assess the conditional improvement of forecasts.
The Changing Weather Information Landscape: Observations, Conjectures, and Thoughts about the Future
Authors: Krocak Makenzie J. , Ripberger Joseph , Berry Kodi , Silva Carol , Jenkins-Smith Hank 
Published: July 2024

Abstract
Numerous changes to information technology and media consumption over the last 2 decades have facilitated a fundamental shift in how people receive information, including weather forecasts. Historically, weather information was generally vetted through experts (often broadcast meteorologists) to members of the public in a relatively top-down system. Now, with the availability of internet websites, phone applications, and social media, people have an increasingly diverse set of sources from which to get weather forecasts. In this piece, we present results from CONUS-wide surveys that show this diversification of weather sources for nonroutine weather events. While older respondents still tend to get weather information from television, younger respondents are increasingly reliant on less traditional sources, including phone notifications, internet websites, social media, and family and friends. This shift to nontraditional sources means that a more diverse set of actors will have the opportunity to provide weather information to users, which could impact the quality, reliability, and accessibility of the weather information in the future.
Perceptions and experiences of clinicians and correctional officers facilitating palliative care for people in prison: A systematic review and meta-synthesis
Authors: Schaefer Isabelle , Panozzo Stacey , DiGiacomo Michelle , Heneka Nicole , Phillips Jane L. 
Published: July 2024

Background: As the number of people ageing in prison with complex healthcare needs continues to increase, so does the need for palliative care in the restrictive prison context. Palliative care for people in prison is facilitated by correctional officers, and prison- and hospital-based clinicians. A collective analysis of existing research to identify common experiences of these stakeholders globally has not been completed. Aim: To explore the perceptions and experiences of correctional officers and prison- and hospital-based clinicians who facilitate palliative care for people in prison. Design: A systematic review and meta-synthesis. Data sources: Keywords and subject headings related to palliative care and prisons were used to search seven databases with no time limitations. Peer-reviewed research in English, containing qualitative data from stakeholders facilitating palliative care for people in prison were included, and appraised using the CASP tool. Results: Two analytical themes emerged: (i) a prison lens on a palliative approach and (ii) coping complexities. Palliative care is ‘translated’ into the prison setting according to security and environmental constraints. Stakeholders experienced ethical, personal and professional difficulties, because prison-based palliative care did not align with community norms. Ambiguous policy and expectations regarding prioritising care needs and balancing custodial rules led to role stress. Conclusions: Providing palliative care for people in prison is complex and impacts stakeholders and people in prison with palliative care needs. Supporting person-centred care through a multi-service approach, stakeholder education and standards will improve the quality and accessibility of care.
The effects of short-time air pollution, SO2, and ozone on biochemical, histo-pathological, oxidative stress, and carcinogenesis related genes expressions in the liver of the rats
Authors: Sepehri Bita , Darbani Roya , Mesgari-Abbasi Mehran , Kheirouri Sorayya , Shanehbandi Dariush , Khordadmehr Monireh , Alizadeh Mohammad 
Published: July 2024

Objective of the Research Air pollution is a universal issue and has significant deleterious effects on both human health and also environment. The important indicators of air pollution include ozone (O3), particulate matter (PM), nitrogen dioxide (NO2), and sulfur dioxide (SO2). This research aims to investigate the impacts of ambient air pollution (AAP), SO2, and O3 on oxidative stress parameters, liver tissue histopathology, and expression of some carcinogenesis-related genes in the hepatic tissue of rats. Materials and Methods 32 Wistar rats were randomly allocated to four groups: the control group, the AAP group, the SO2 group (10 ppm), and the ozone group (0.6 ppm). Over a period of five consecutive weeks, the rats were exposed to the specified pollutants for 3 h daily; liver tissues were harvested and instantly fixed with formalin. Pathological changes were assessed in the tissue samples. Additionally, the RT-qPCR technique was utilized to investigate Expression alterations of BAX, p-53, BCL2, caspase-3, caspase-8 and caspase-9. Furthermore, 30 milligrams of hepatic tissues were extracted to assess the activities of oxidative stress enzymes. Results The liver catalase and MDA activity were elevated in the air pollution ( p < .05). Also, liver GPx activity in air pollution and ozone groups was significant in comparison to the control group ( p < .05). The SO2 group exhibited severe lesions in histopathology examinations. Conclusions The findings revealed an alteration in liver histopathology, an induction of oxidative stress, and the expression of some apoptosis-related genes in hepatic tissues after exposure to AAP, SO2, and O3.
Management of Metastatic Spinal Disease – A Practical Approach
Authors: Shea Graham Ka Hon , Kwan Kenny Yat Hong 
Published: July 2024

Study Design Narrative review. Objective This review presents a comprehensive approach to the management of spinal metastases. Methods N/A. Results The wide spectrum of clinical presentation in spinal metastases necessitates a personalized approach to treatment planning. This includes a comprehensive diagnostic workup, oncological management, palliation of symptoms, and surgical intervention if appropriate. A systematic and multidisciplinary approach allows optimal shared decision making to reach an evidence-informed and value-congruent treatment plan for the patient. We highlight how advances in stereotactic body radiotherapy (SBRT) and separation surgery may be incorporated into clinical management from a spine surgeon’s perspective. Conclusion This review summarizes the approach and management of spinal metastases, its outcomes and complications.
Costs and Timing of Surgery in the Management of Meniscal Tears
Authors: Nin Darren Z. , Chen Ya-Wen , Mandalia Krishna , Parman Michael , Shah Sarav S. , Ramappa Arun J. , Chang David C. , Matzkin Elizabeth G. 
Published: July 2024

Background: Treatment strategies for meniscal tears range from nonoperative management to surgical intervention. However, national trends in cost-related outcomes and patient factors related to the failure of nonoperative management remain poorly understood. Purpose: To describe the costs associated with nonoperative versus operative management of meniscal tears in the 2 years after diagnosis and examine the relationship between patient characteristics and timing of surgery. Study Design: Cross-sectional study; Level of evidence, 3. Methods: This study was conducted using the MarketScan databases. Patients diagnosed with a meniscal tear without concomitant knee osteoarthritis between January 1 and December 31, 2017, were included. The primary outcome was the total cost of meniscal tear-related procedures—including insurance deductibles, coinsurance, and net insurance payments—in the 2 years after diagnosis. Procedures included were as follows: (1) surgery—including meniscectomy or meniscal repair; (2) physical therapy; (3) medication—including nonsteroidal anti-inflammatories, opioids, and acetaminophen; (4) intra-articular injections—including professional fee, hyaluronic acid, and corticosteroids; (5) imaging; and (6) clinic visits to orthopaedic specialists. Patients were grouped as having undergone early surgery (ES) (≤3 months of diagnosis), late surgery (LS) (>3 months after diagnosis), or no surgery (NS). Multivariate logistic regression was performed to determine the likelihood of undergoing surgery early and failing nonoperative treatment. Results: The study population included 29,924 patients with a mean age of 43.9 ± 12.9 years (ES: n = 9507 (31.8%); LS: n = 2021 (6.8%); NS: n = 18,396 (61.5%)). Complex (36.6%) and medial (58.8%) meniscal tears were the most common type and location of injuries, respectively. The mean cost of management per patient was $3835 ± $4795. Costs were lower in the NS group ($1905 ± $3175) compared with the ES group ($6759 ± $5155), while the highest costs were observed in the LS group ($7649 ± $5913) ( P < .001). Patients who were men, >40 years, and with a bucket-handle or lateral meniscal tear were more likely to undergo surgery early. Patients who were men, <30 years, and with a complex tear or tear to the lateral meniscus were more likely to fail nonoperative management. Conclusion: Nonoperative management had the lowest cost burden and should be recommended for patients with appropriate indications. However, if surgery is necessary, it should be performed earlier.
A novel transdermal drug delivery system: drug-loaded ROS-responsive ferrocene fibers for effective photoprotective and wound healing activity
Authors: Kim Sangwoo , Kim Yoon , Kim Chaehyun , Choi Won Il , Kim Byoung Soo , Hong Jinkee , Lee Hoik , Sung Daekyung 
Published: July 2024

AbstractThe present study proposes an innovative transdermal drug delivery system using ferrocene-incorporated fibers to enhance the bioavailability and therapeutic efficacy of ascorbyl tetraisopalmitate. Using electrospinning technology, the authors created ferrocene polymer fibers capable of highly efficient drug encapsulation and controlled release in response to reactive oxygen species commonly found in wound sites. The approach improves upon previous methods significantly by offering higher drug loading capacities and sustained release, directly targeting diseased cells. The results confirm the potential of ferrocene fibers for localized drug delivery, potentially reducing side effects and increasing patient convenience. The method could facilitate the application of bioactive compounds in medical textiles and targeted therapy.