bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temperament, parenting, and South Korean early adolescents’ physical aggression: A five-wave longitudinal analysis
Authors: Lee Julie 
Published: February 2013

Objective: This study examined the growth pattern in physical aggression over a five-year period among South Korean early adolescents and the effects of temperament (anger/frustration and emotion regulation) and parenting (harsh parenting and parental monitoring) on early adolescents’ physical aggression. Design: A five-year longitudinal design was used to explore the growth pattern in physical aggression. Method: Participants were 2844 early adolescents (1320 girls and 1524 boys; M age = 9.86 years, SD = 0.35 at wave 1) in the Korea Youth Panel Study (KYPS), a national representative of Korean children and adolescents. The latent growth curve model (LGM) was used for data analysis. Results: There was a significant linear growth over time in physical aggression during early adolescence. However, there were significant individual differences of developmental trajectories of adolescent aggression. The initial level of aggression in early adolescence was positively associated with anger/frustration, and the rate of change in aggression was negatively related to emotion regulation. Parenting variables, which were harsh parenting and parental monitoring, were not related to the initial level and rate of change in physical aggression. Conclusion: Temperament variables (anger/frustration, emotion regulation) cause the individual differences in initial level of aggression and rate of change in aggression.
The effect of normovolemic modified ultrafiltration on inflammatory mediators, endotoxins, terminal complement complexes and clinical outcome in high-risk cardiac surgery patients
Authors: Papadopoulos N , Bakhtiary F , Grün V , Weber CF , Strasser C , Moritz A 
Published: February 2013

Objective: The clinical benefit of normovolemic modified ultrafiltration (N-MUF) after cardiac surgery is still debated. As we have shown in a previous publication, there is a significant improvement in platelet function, so we were interested in whether ultrafiltration can reduce plasma levels of endotoxins, terminal complement complexes and cytokines after cardiopulmonary bypass (CPB) in adults with increased risk profiles. Methods: In this single-center, prospective, randomized trial, fifty high-risk patients (mean logistic EuroSCORE II: 17.5%) who underwent cardiac surgery were randomized. After CPB, Group 1 (n = 25) served as the control and in, Group 2 (n= 25), an N-MUF of 3000 ml was performed, using a BC140plus filter after weaning from CPB. Blood samples were taken after the induction of anesthesia, before CPB, before CPB weaning, 30 minutes after CPB and at 6, 24 and 48 hours postoperatively. Primary outcomes were plasma levels of lipopolysaccharide-binding protein (LBP), terminal complement complex (C5b9) and cytokines (IL-6, IL-10, IL-1beta, TNF-α). Secondary outcomes focused on differences in the clinical outcome. Results: A significant reduction in LBP concentration (preoperatively: 23.8±8.4 pg/ml, postoperatively: 14.2±12.9 pg/ml) and C5b9 (preoperatively: 4.18±2.6 pg/ml, postoperatively: 3.05±2.39 pg/ml) were detected 6 hours after N-MUF. In the N-MUF group, significantly lower concentrations of lactate could be detected in the early postoperative period. Furthermore, postoperative chest tube blood loss was significantly lower in the N-MUF group at 24 and 48 hours. Conclusions: N-MUF leads to a significant reduction of lipopolysaccharide-binding protein and terminal complement complex and was associated with reduced blood loss and postoperative lactate concentrations shortly after surgery.
Haplotype analysis of the folate-related genes MTHFR, MTRR, and MTR and migraine with aura
Authors: Roecklein Kathryn A , Scher Ann I , Smith Albert , Harris Tamara , Eiriksdottir Gudny , Garcia Melissa , Gudnason Villi , Launer Lenore J 
Published: February 2013

Aims The C677T variant in the methylenetetrahydrofolate reductase ( MTHFR; EC 1.5.1.20) enzyme, a key player in the folate metabolic pathway, has been associated with increased risk of migraine with aura. Other genes encoding molecular components of this pathway include methionine synthase ( MTR; EC 2.1.1.13) and methionine synthase reductase ( MTRR; EC 2.1.1.135) among others. We performed a haplotype analysis of migraine risk and MTHFR, MTR, and MTRR. Methods Study participants are from a random sub-sample participating in the population-based AGES-Reykjavik Study, including subjects with non-migraine headache ( n = 367), migraine without aura ( n = 85), migraine with aura ( n = 167), and no headache ( n = 1347). Haplotypes spanning each gene were constructed using Haploview. Association testing was performed on single SNP and haplotypes using logistic regression, controlling for demographic and cardiovascular risk factors and correcting for multiple testing. Results Haplotype analysis suggested an association between MTRR haplotypes and reduced risk of migraine with aura. All other associations were not significant after correcting for multiple testing. Conclusions These results suggest that MTRR variants may protect against migraine with aura in an older population.
Relationship Between Markers of Type II Collagen Metabolism and Tibiofemoral Joint Space Width Changes After ACL Injury and Reconstruction
Authors: Tourville Timothy W. , Johnson Robert J. , Slauterbeck James R. , Naud Shelly , Beynnon Bruce D. 
Published: February 2013

Background: Those who suffer anterior cruciate ligament (ACL) disruptions are at increased risk of experiencing posttraumatic osteoarthritis (OA); however, by the time they become symptomatic, irreversible damage has likely occurred. Little is known regarding the physiological changes in articular cartilage that occur after an ACL injury and the onset of OA. Purpose: To assess whether patient, functional, and clinical outcomes and type II collagen metabolism are associated with abnormal tibiofemoral joint space width (JSW) 4 years after injury and reconstruction. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 35 ACL-injured patients who underwent ACL reconstruction were enrolled soon after injury, as were 32 matched controls. At baseline and 1- and 4-year follow-ups, patient-oriented subjective and objective outcomes and markers of type II collagen metabolism (considered as the ratio of cleavage to synthesis of type II collagen) were evaluated, as were radiographic measurements of JSW changes about the medial and lateral compartments of the knee. ACL-injured patients were divided into normal and abnormal JSW groups. Results: Both ACL-injured groups (normal and abnormal JSW) had an increased ratio of collagen type I and II cleavage product (uC1,2C) to serum procollagen II C-propeptide (sCPII) compared with controls at 1- and 4-year follow-ups. Patients in the ACL group with an abnormal JSW difference had significantly increased cleavage-to-synthesis ratios of type II collagen (assessed as C-terminal cross-linked telopeptide of type II collagen [uCTX-II]/sCPII ratio) compared with controls at 4-year follow-up. ACL-injured patients with an abnormal JSW difference had significantly increased pain and decreased quality of life (Knee Injury and Osteoarthritis Outcome Score [KOOS]) scores than did ACL-injured patients with a normal JSW difference. Conclusion: ACL-injured patients with an abnormal tibiofemoral JSW had diminished quality of life, increased pain, and increased type II collagen uCTX-II/sCPII ratios compared with healthy controls. These changes occurred over an interval shortly after injury in patients who were fully functional and who had normal clinical examination findings, no pivoting/giving-way episodes, and no decrease in activity level.
Prevalence and Preoperative Demographic and Radiographic Predictors of Bilateral Femoroacetabular Impingement
Authors: Klingenstein Gregory G. , Zbeda Robert M. , Bedi Asheesh , Magennis Erin , Kelly Bryan T. 
Published: February 2013

Background: Patients with symptomatic femoroacetabular impingement (FAI) frequently have bilateral deformity and inquire about the prognosis of their contralateral, asymptomatic hip. Idiopathic coxarthrosis has been established as an independent risk factor for joint failure on the other side. Purpose: To determine the prevalence of bilateral arthroscopic treatment for FAI and to identify predictive patient demographics and radiographic findings for bilateral, symptomatic disease. Study Design: Case control study; Level of evidence, 3. Methods: Over a 2-year period, patients receiving single-sided FAI surgery for pain and radiographic deformity were identified as unilateral. In the same period, patients undergoing their second side were labeled bilateral, regardless of when the first surgery was performed. Proximal femoral alpha angle; lateral center edge angle; sagittal center edge angle; acetabular version at 1, 2, and 3 o’clock; and femoral torsion were measured on preoperative computed tomography scans. Results: The unilateral group included 514 patients, and the bilateral group included 132 patients. Women composed 48% of the unilateral group but only 35% of the bilateral group ( P = .006). The mean age of unilateral patients was 30.3 (±10.7) years and 27.6 (±9.7) years for the first side of bilateral patients ( P = .010). The bilateral hips had higher alpha angles (63.8° vs 59.8°, P = .004), less acetabular anteversion at the 3-o’clock position (13.0° vs 15.9°, P < .001), and similar femoral torsion (15.1° vs 15.5°, P = .793) compared with unilateral hips. A multivariable logistic regression model found that for every 5 years of younger age, 5° higher alpha angle, and 5° decrease in 3-o’clock acetabular version, patients were more likely to undergo bilateral treatment for FAI, by 13.5%, 14.5%, and 25.5%, respectively. In a side-to-side comparison of both hips in bilateral patients, alpha angle ( r = 0.72) and acetabular version at 1 o’clock ( r = 0.73) showed high correlation. Conclusion: Male sex, younger age, higher alpha angles, and reduced acetabular anteversion at initial presentation are significant risk factors for identifying patients who may ultimately require bilateral surgery for symptomatic FAI. Among bilaterally treated patients, no radiographic parameters were predictive of which side would require treatment first. Patients with FAI requiring surgery should be closely monitored for contralateral hip disease.
Qualitative validation of the FACIT-Fatigue scale in systemic lupus erythematosus
Authors: Kosinski M , Gajria K , Fernandes AW , Cella D 
Published: February 2013

Objective Fatigue in systemic lupus erythematosus (SLE) is burdensome and must be assessed using validated scales. Although the psychometric properties of the Functional Assessment of Chronic Illness Therapy–Fatigue (FACIT-Fatigue) scale in SLE have been evaluated previously, its content validity in this disease remains to be evaluated. The study objective was, therefore, to evaluate content validity of the FACIT-Fatigue in SLE. Methods Three SLE focus groups ( n = 21) in the United States were conducted using semi-structured interviews. Participant comments were categorized by response type, and relative response strength was qualitatively assessed. Results Participants were mostly female (90%; n = 19), white (57%; n = 12) with a mean age of 43.7 years (range = 28–70). Most scale items were considered relevant with the exception of four items for which participant interpretations varied . Consistent with the scale’s measurement model, “listless” on item 3 (“ I feel listless (‘ washed out’)”) was interpreted as physical or mental impairment. Participant responses to item 8 (“ I am able to do my usual activities”) sometimes included influence of other health conditions, which is acceptable because it is difficult to separate disease-specific and general fatigue. Some participants found item 7 (“ I have energy”) irrelevant and most could not relate to item 10 (“ I am too tired to eat”). However, both items were intended to capture the extreme ends of fatigue (item 7, ceiling; item 10, floor). Conclusions From a content perspective, items of the FACIT-Fatigue scale were relevant for measuring fatigue in SLE.
Hearing and vestibular disorders in patients with systemic lupus erythematosus
Authors: Batuecas-Caletrío A , del Pino-Montes J , Cordero-Civantos C , Calle-Cabanillas MI , Lopez-Escamez JA 
Published: February 2013

Objectives Systemic lupus erythematosus (SLE) is associated with several comorbidities, including hearing and vestibular disorders. We recently described an increase of SLE prevalence in patients with Menierés disease (MD). The aim of this study is to explore if a subset of SLE patients may have a common inner ear disorder and determine the potential relationship with migraine. Methods Eighty-nine patients with SLE (according to the American College of Rheumatology criteria for the diagnosis of SLE) were evaluated for audiovestibular symptoms by a telephone interview carried out by two experienced otoneurologists. Twenty-one patients with SLE were referred to the otoneurology clinic for a detailed clinical history for criteria assessment for MD and a complete audiovestibular examination (audiogram, oculomotor, and caloric testing with video-oculography). Results Recurrent headache was found in 50/89 patients, and 26 of them had diagnostic criteria for migraine. Twenty-four percent of patients reported sensorineural hearing loss (SNHL) or episodic vertigo. Among the eight patients (9%) with episodic vertigo, one had criteria for definite MD and another two patients had criteria for possible MD. SNHL was found to be associated with a history of episodic vertigo (Fisher’s test, p = 0.02), but not with headache or migraine. SLE and episodic vertigo were not associated with tinnitus, migraine, lupus nephritis, antinuclear antibodies or antiphospholipid syndrome. Conclusions Migraine, SNHL and episodic vertigo are comorbid conditions in patients with SLE, but migraine is not associated with SNHL or vertigo in these patients. However, SNHL and vertigo are associated conditions in SLE, suggesting a common audiovestibular dysfunction.
Implementation of Do Not Attempt Resuscitate Orders in a Japanese Nursing Home
Authors: Asai Nobuhiro , Ohkuni Yoshihiro , Ashworth Lonny , Kaneko Norihiro 
Published: February 2013

Objective: To investigate whether do not attempt resuscitation (DNAR) orders can be implemented in a standard nursing home in Japan, where routine DNAR orders are not yet common in many facilities including hospitals. Method: Ninety-eight residents in a 100-bed nursing home were evaluated. All of the eligible residents and/or their family members were asked whether they wanted to receive resuscitation, including mechanical ventilation. Result: The residents were 54 to 101 years of age (mean 83.3), with 27 males and 71 females. After administering the questionnaire, 92 (94%) patients did not want resuscitation and mechanical ventilation. Conclusion: In a nursing home, it was possible to obtain advance directives by which most residents/families rejected resuscitation and mechanical ventilation. This could avoid unnecessary and undesirable resuscitation procedures.
Integrating Massage Therapy Within the Palliative Care of Veterans With Advanced Illnesses
Authors: Mitchinson Allison , Fletcher Carol E. , Kim Hyungjin Myra , Montagnini Marcos , Hinshaw Daniel B. 
Published: February 2013

Aims: To describe the integration of massage therapy into a palliative care service and to examine the relationship between massage and symptoms in patients with advanced illnesses. Methods: Between April 1, 2009, and July 31, 2010, 153 patients received massage at the VA Ann Arbor Health Care System. Data on pain, anxiety, dyspnea, relaxation, and inner peace were collected pre and post massage. Diagnoses, chronic pain, and social support were also abstracted. Analysis of covariance was used to examine changes over time. Results: All short-term changes in symptoms showed improvement and all were statistically significant. Pain intensity decreased by 1.65 (0-10 scale, P < .001), anxiety decreased by 1.52 (0-10 scale, P < .001), patients’ sense of relaxation increased by 2.92 (0-10 scale, P < .001), and inner peace improved by 1.80 (0-10 scale, P < .001). Conclusion: Massage is a useful tool for improving symptom management and reducing suffering in palliative care patients.
Three-Dimensional, Digital, and Gross Anatomy of the Lisfranc Ligament
Authors: Panchbhavi Vinod K. , Molina Domingo , Villarreal Jaime , Curry Michael C. , Andersen Clark R. 
Published: February 2013

Background: There are inconsistencies in the descriptive anatomy of the Lisfranc ligament. No information is available on orientation of fibers or presence of bundles, nor are there 3-dimensional anatomic data on the ligaments or their attachments. This study assessed the 3-dimensional anatomy of the Lisfranc ligament and its attachment sites. Methods: A total of 37 cadaver feet were dissected to expose the ligament attachments at the Lisfranc joint. The Lisfranc ligament and plantar ligament attachments were outlined separately and then removed with the attachment outlines preserved. A 3-dimensional digitizer was used to digitize bony and articular surfaces, as well as ligament attachment sites, at approximately 1 mm intervals; the positional accuracy was 0.23 mm. The surface areas of the entire bone, articular regions, and Lisfranc and plantar ligament attachment regions were determined and anatomic details were noted. Results: The Lisfranc ligament had a single bundle in 73% of the specimens and 2 bundles in 27%. Both variations had a single attachment to the second metatarsal (M2; mean attachment surface area, 135 mm2). The single-bundle variation attached to the medial cuneiform (C1; mean attachment surface area, 140 mm2). The plantar ligament, C1-M2-M3, attached to the anterior plantar surface of the lateral aspect of C1 (mean attachment surface, 64 mm2) and had attachment sites at the bases of M2 and M3. Its fibers ran anteriorly and inferiorly, with attachments to the proximal inferomedial aspect of M2 (mean attachment surface, 63 mm2) and fibers extending to a smaller attachment at the plantar aspect of M3 (mean attachment surface area, 26 mm2). Conclusion: The Lisfranc ligament is variable in anatomy and can have a single- or double-bundle arrangement. Its area of attachment is larger than that of the plantar ligament. Clinical Relevance: Anatomic descriptions of location, dimensions, and variability in the position and surface area of the ligament attachment sites and of orientation of the bundles provide information for future attempts at repair or reconstruction of the Lisfranc ligament.
Acceptability of Oral versus Rectal HIV Preexposure Prophylaxis among Men Who Have Sex with Men and Transgender Women in Peru
Authors: Peinado Jesus , Lama Javier R. , Galea Jerome T. , Segura Patricia , Casapia Martin , Ortiz Abner , Montano Silvia M. , Kochel Tadeusz , Sánchez Jorge 
Published: February 2013

Objective: Oral preexposure prophylaxis (PrEP) with antiretrovirals (ARVs) is at the forefront of biomedical HIV prevention research, and ARVs are also being tested for rectal administration to target people practicing unprotected receptive anal intercourse (URAI) and at risk of HIV infection. This study assessed the acceptability of daily oral PrEP and rectal PrEP during URAI among men who have sex with men (MSM) and transgender women (TGW) in Peru. Methods: During the 2008 HIV sentinel surveillance survey conducted in 3 Peruvian cities (Lima, Iquitos, and Pucallpa), MSM and TGW reported being “versatile,” “most of the time receptive,” and “exclusively receptive” during anal sex behavior where surveyed on their acceptability of oral and rectal PrEP. Results: Among 532 individuals, high acceptance of either oral (96.2%) or rectal (91.7%) PrEP products was reported. If both products were efficacious/available, 28.6% would prefer a pill, 57.3% a rectal lubricant, and 14.1% either. A trend toward higher acceptance was observed as receptive anal sex behavior exclusivity rose ( P = .013). Being receptive most of the time (adjusted odds ratio [aOR]: 9.1, P = .01) and exclusively receptive (aOR: 7.5, P = .01), compared to being versatile, were independently associated with oral PrEP acceptability. A similar association was found with the acceptability of rectal formulations (aOR: 2.3, P = .07; and aOR: 2.5, P = .02; respectively). Conclusions: Oral and rectal PrEP were highly acceptable among Peruvian MSM and TGW, particularly among those at the highest HIV infection risk. These data can guide the implementation of PrEP programs in Peru and similar settings and populations.
Tibialis Anterior Tendon Entrapment After Ankle Tightrope Insertion for Acute Syndesmosis Injury
Authors: Welck Matthew James , Ray Pinak 
Published: February 2013

Ankle syndesmotic injuries often require anatomic reduction and fixation. Syndesmosis screw fixation is commonly used; however, this prevents physiological motion at the joint, often requires a second operation for screw removal, and may limit postoperative weight bearing. The Ankle Tightrope (Arthrex, Naples, FL) was introduced to allow physiological tibiofibular micromotion, early ankle range of motion, and weight bearing, and did not require a second operation for removal. For Maisonneuve injuries, or more severe syndesmosis instability, a second tightrope is required. This is advised to be placed 1 cm above the first with axial divergence in the coronal plane to increase rotational stability. Initial series have shown the main complications of tightrope fixation to be knot prominence or wound complications. Other documented complications include erosion of the buttons into bone, synostosis, and diastasis. This is the first report of tendon entrapment from the medial button. Reasons for this are discussed with suggestions for surgical technique. Levels of Evidence: Therapeutic, Level IV
Incidental Findings on Upper Gastrointestinal Endoscopic Ultrasonography
Authors: Sotoudehmanesh Rasoul , Arab Payman , Ali-Asgari Ali 
Published: February 2013

Objective: The aim of this prospective study was to assess the frequency and clinical significance of incidental findings on upper gastrointestinal endoscopic ultrasonography (EUS). Methods: Patients referred for upper gastrointestinal EUS were consecutively enrolled into this prospective study. Any coincidental abnormality found during standard EUS was considered an incidental finding. Significant incidental findings were defined as abnormalities that required further medical, surgical, or endoscopic intervention, including surveillance. Results: In 552 patients who underwent EUS, 41 incidental findings were detected in 39 patients (7.1%). Twenty-one abnormalities had clinical significance. The frequency of incidental findings increased significantly with increasing age ( P = .001). The most frequent incidental findings were gallstones, subepithelial lesions, and pancreatic lesions. Conclusions: Incidental findings on EUS are not uncommon in clinical practice and might be a clue to a significant pathology. The appropriate extent of evaluation of incidental findings noted during a standard EUS procedure warrants further research yet to be defined.