bluuebunny/crossref_metadata_2025_split huggingface dataset:
ZFP36, an RNA-binding protein promotes hBMSCs osteogenic differentiation via binding with JUN
Authors: Su Hairong , Liang Linyuan , Wang Junling , Yuan Xiaolu , Zhao Binxiu 
Published: August 2024

Abstract

Osteoporosis (OP) is a metabolic bone disease characterized by progressive decline of bone mass and bone quality, leading to bone fragility and an increased risk of fracture. The osteogenic differentiation of bone mesenchymal stem cells (BMSCs) is crucial to maintain the balance of osteoblast and osteoclast. Bioinformatics prediction indicates that ZFP36 ring finger protein (ZFP36), an RNA-binding protein, is a potential target of OP. Herein, we sought to probe the regulatory role and mechanisms of ZFP36 in the progression of OP. Overexpression of ZFP36 enhanced osteoblast viability, differentiation and mineralization of human BMSCs (hBMSCs). RNA immunoprecipitation qPCR (RIP-qPCR) assays demonstrated that ZFP36 could inhibit the translation of JUN, which was also verified with dual luciferase reporter gene assay. Furthermore, administration with T-5224, a transcription factor c-Fos/activator protein (AP)-1 inhibitor, which specifically inhibits the DNA binding activity of c-Fos/JUN, abolished the effect of ZFP36 knockdown on the behaviors of hBMSCs, suggesting that ZFP36 might promotes osteogenic differentiation through regulating JUN. These findings provide insights into the progression and a potential therapeutic target of OP.
Adapting to the Heat, Fighting with the Bite: A Two-fold Risk Assessment Coupling Indoor Heat Stress and Malaria Disease in Traditional African Settlements
Authors: Bardhan Ronita , Li Haiwei , Raman Haimavati , Abong'o Bernard , Bange Teresa , Zhao Yongling , Brayne Carol 
Published: August 2024

Abstract

Background Global south faces detrimental impacts of climate change, particularly the escalation of extreme heat and the heightened prevalence of vector-borne diseases. Building-level risk mitigation strategies frequently exhibit synergistic or conflicting effects on the two-fold risk. This research investigates health risks posed by indoor heat and malaria transmission in Kisumu, Kenya, across 138 local residents and their thirty traditional rural settlements, which are examined in their original architectural forms and modified forms.
Methods This study introduces a coupled health risk assessment method, examining indoor heat stress and malaria transmission. It computes risk indices by evaluating exposure, vulnerability, and hazard, aligning with the IPCC’s risk assessment framework. The approach combines environmental monitoring data, computational fluid dynamics (CFD) simulations, and questionnaire surveys to analyze risk in homes, including factors related to the architectural designs and residents.
Findings Our findings suggest that traditional informal settlements with overcrowding issues, extensive cooking activities, and limited ventilation facilities significantly heightened indoor exposure and vulnerabilities. Four houses classified as having extreme high heat stress risk demonstrate indoor air temperatures where over 70% of the volume exceeds 30°C, and over 10% of the volume exceeds 35°C. Our results underscore the importance of roof-level ventilation by open eaves, which promotes natural airflow, disperses heat trapped near the ceiling, and improves indoor air circulation. Such intervention resulted in a considerable rise in the proportion of houses categorized as low to medium risk, with only two out of thirty houses remaining as high-risk homes. Moreover, the installation of windows has conflicting effects, facilitating heat mitigation and increasing the risk of mosquito entry. The adaptive schedules for opening kitchen windows and front-and-back-door design interventions can reduce the risks.
Interpretation Our research reveals a complex interplay of demographic and socioeconomic factors, occupancy behavioral adaptations, and architectural modifications as influential intervention factors in indoor thermal comfort and malaria disease transmission control. By addressing these architectural and behavioral adaptation aspects, our study contributes valuable insights into striking a balance of exposure and hazard risks in the context of vulnerable neighborhoods in Kenya.
Funding OODA Global Challenges Research Fund (GCRF) and Newton Consolidation Accounts Research Fund Award
Methodological features of the description of thermal conductivity processes
Authors: Куликов А. А. , Иванова И. В. , Дюкова И. Н. 
Published: August 2024

В физической модели процесса теплопроводности анализируется роль скорости, с которой в сплошной среде распространяется энергия. На базе общего определения вектора плотности энергии даётся основное определение вектора плотности теплового потока и выводится формула для определения объёмной плотности энергии, переносимой за счёт теплопроводности. Для общего случая выводится формула расчёта распределения локальной поверхностной плотности теплового потока на произвольной поверхности, принадлежащей телу, при известном поле вектора плотности теплового потока.
In the physical model, the role of the velocity at which energy propagates in a continuous medium is analyzed in the process of thermal conductivity. Based on the general definition of the energy density vector, the basic definition of the heat flux density vector is given and a formula is derived for determining the volumetric energy density transferred due to thermal conductivity. For the general case, a formula is derived for calculating the distribution of the local surface heat flux density on an arbitrary surface belonging to a body with a known field of the heat flux density vector.
Natural renewal of the forest in drained pine forests, passed by complex logging
Authors: Смирнов А. П. , Смирнов А. А. 
Published: August 2024

Опытные комплексные рубки проводились в разновозрастных сосняках в 1984 г., через 17 лет после устройства каналов на верховом торфянике. Удалялась старовозрастная часть древостоя, в молодой части проводилось разреживание. В год проведения рубок подрост сосны имелся на всех участках в количестве 7-10 тыс. экз./га. В течение последующих 15 лет (к 1999 г.) количество подроста сосны уменьшилось до 0,2-3,3 тыс. экз./га. Еще через 15 лет (2014 г.) подрост сосны полностью перешел в отпад. По-видимому, основной причиной явилась усилившаяся конкуренция за свет и питательные вещества почвы со стороны интенсивно растущего древостоя. Подрост берёзы сформировался через 15 лет после рубок на всех участках в количестве 0,4-4 тыс. экз./га. Еще через 15 лет (2014 г.) густота березы на большинстве участков возросла до 2-5 тыс. экз./га, и к настоящему времени (2023 г.) это количество почти не изменилось. Тем самым подтверждается, что молодое поколение березы лучше адаптируется к новым условиям на осушаемых объектах по сравнению с сосной. Больше подроста березы у каналов, где лучше световой и питательный режим. Подрост ели в год проведения рубок встречался единично. К 1999 г. густота подроста ели на отдельных участках составляла 0,1-0,4 тыс. экз./га, и в дальнейшем почти не увеличивалась. Несмотря на крайне незначительное количество елового подроста и его неравномерное распределение по площади, за последние 15-25 лет практически отсутствует его отпад.
Experimental complex felling was carried out in pine forests of different ages in 1984, 17 years after the construction of canals on the upland peat bog. The old-growth part of the stand was removed, and thinning was carried out in the young part. In the year of felling, pine undergrowth was available in all areas in the amount of 7-10 thousand specimens per hectare. Over the next 15 years (by 1999) the amount of pine undergrowth decreased to 0.2-3.3 thousand ind. per hectare. Apparently, the main reason was the increased competition for light and soil nutrients from the intensively growing stand. Birch undergrowth was formed in 15 years after felling in all areas in the amount of 0.4-4 thousand specimens per hectare. After another 15 years (2014), the density of birch in most areas increased to 2-5 thousand ind./ha, and by now (2023) this amount has not changed much. Thus, it is confirmed that the young generation of birch is better adapted to new conditions on drained objects compared to pine. There is more birch undergrowth near the canals, where the light and nutritional regime is better. In the year of felling, spruce undergrowth was found sporadically. By 1999, the density of spruce undergrowth in some areas was 0.1-0.4 thousand specimens per hectare, and in the future it almost did not increase. Despite the extremely small amount of spruce undergrowth and its uneven distribution over the area, over the past 15-25 years there has been practically no loss of it.
Gobierno Abierto y Universidad. Experiencias y resultados desde la cooperación Universidad- Estado en temáticas de Sustentabilidad Ambiental en Universidades de la Región Caribe 2018-2022
Authors: Obregón Rodríguez Celina , Amézquita López Julio , Perozo Edison 
Published: August 2024

El gobierno abierto refiere a un cambio de paradigma de gestión pública que atraviesa a las instituciones de todos los poderes del Estado, en tanto que el mismo sostiene que la relación con la ciudadanía debe ser el centro del accionar y de la toma de decisiones del quehacer público. El objetivo de este artículo es Evaluar el estado de la cooperación Universidad – Gobierno – Corporaciones ambientales frente a la estrategia de gobierno abierto en la dimensión ambiental con énfasis en cambio climático. La hipótesis formulada es la existencia de una baja implementación de Políticas Públicas pesar de profusión de convenios Universidad-estado. La metodología utilizada es del tipo descriptiva, por cuanto se desarrolló una evaluación sobre los fenómenos sociales identificados para evaluar el estado de la cooperación Universidad- Estado- Corporaciones Ambientales, el diseño de la investigación utilizada es del tipo no experimental de campo, debido a que no se manipulo la variable, y se trabajó directamente en los sitios o campos donde sucedieron los fenómenos, en este caso las universidades de la Región Caribe. Dentro de los resultados logrados con la investigación se observó que las iniciativas por parte de las universidades son muy extensas y significativas para aportar a la formulación de nuevas políticas públicas, frente a escenarios de apuesta frente al cambio climático desarrollados e identificados desde estas instituciones de educación superior como son: Agua y abastecimiento, protección y conservación de los ecosistemas para mantener la sostenibilidad ambiental, preservación de diversidad, actividades económicas ambientalmente sostenibles y socialmente responsables, promoción del desarrollo de los recursos hidrobiológicos, implementación de estrategias de adaptación al cambio climático, desarrollo urbano y rural ambientalmente sostenible, desarrollo de actividades empresariales responsables y oferta turística responsable con el medio ambiente. El articulo concluye que las universidades son un foco de generación de nuevo conocimiento frente a temas de cambio climático, siendo de vital importancia la adopción de nuevas estructuras en red, la colaboración y co-creación de políticas públicas que promuevan la interacción, la conversación y el diálogo de doble vía entre el Estado- Universidades y Corporaciones ambientales para la generación de estrategias con resultados efectivos, transparentes y participativos propios de un estado abierto.
Meta-analysis of the frequency of thoracolumbar junction fractures in the context of traumatic spinal injuries in the adult population
Authors: Nekhlopochyn O.S. , Verbov V.V. , Verbovska S.A. , Cheshuk I.V. 
Published: August 2024

Background. Traumatic spinal injuries are a significant medical and social issue, due to both the high costs associated with initial medical care for the injured and the extensive and expensive rehabilitation required. The thoracolumbar junction (TLJ) is prone to injuries due to its biomechanical characteristics. However, the actual frequency of injuries in this area, as reported in the literature, is inconsistent. The purpose of the study was to assess the proportion of fractures at the TLJ within the overall structure of traumatic spinal injuries in the adult population. Materials and me­thods. A meta-analysis was conducted based on searches in the MEDLINE database using MeSH terms and keywords in titles and abstracts to identify studies meeting the inclusion criteria. The search identified 22 full-length articles. Data extraction and analysis were conducted by two independent experts. Results. It was found that fractures at the TLJ accoun­ted for 46.51 % (95% confidence interval (CI): 36.76–56.27 %) of the overall structure of spinal injuries, specifically fractures at level Th11 — 4.26 % (95% CI: 3.35–5.17 %), Th12 — 13.98 % (95% CI: 10.41–17.56 %), at level L1 — 22.21 % (95% CI: 17.66–26.76 %), and L2 — 9.69 % (95% CI: 6.82–12.57 %). Within the thoracolumbar division, the frequency of TLJ trauma was 61.88 % (95% CI: 52.53–71.22 %). Within the TLJ, the frequency of fractures was: vertebra Th11 — 10.2 % (95% CI: 8.05–12.36 %), Th12 — 26.56 % (95% CI: 22.42–30.7 %), vertebra L1 — 42.76 % (95% CI: 39.7–45.81 %), and L2 — 20.48 % (95% CI: 16.73–24.23 %). Conclusions. The meta-analysis provi­ded objective indicators of the frequency distribution of TLJ fractures within the overall structure of traumatic spinal injuries. To our knowledge, this is the first study to provide such detailed information through meta-analysis.
Mobile Library: One Inovation of Literacy Information Reference
Authors: Iqbal Rahmat , Kusuma Mezan El-Khaeri , Yunita Irva , Dinasta Aldy Gyan 
Published: August 2024

AbtrakLiterasi informasi merupakan hal yang sangat dibutuhkan bagi segenap kalangan akademis ataupun kalangam masyarakat biasa dalam meningkat kemampuan dalam pengetahuan dalam sebuah informasi yang lagi terbaru atau yang lagi hangat disaat ini. Lahirnya budaya literasi digital seiring dengan kemajuan dalam teknologi informasi yang melahirkan sebuah kemudahan kepada masyarakat dalam mendapatkan informasi digital tanpa harus memikirkan dari jarak dan lokasi yang mereka upayakan dalam mendapatkan informasi. Transformasi penelusuran informasi di era teknologi informasi menghasilkan sebuah maha karya yang menjadikan sebuah perubahan dalam budaya penelusuran informasi yang awal menggunakan cetak sebagai koleksi referensi menjadi literasi digital dan menggunakan digital buku sebagai referensi informasi digital. Peneliti menggunakan metodologi kualitatif, penelitian ini memakai deskriptif kualitatif. Metode pengumpulan data peneliti menggunakan sistem observasi perhadap aplikasi mobile library, wawancara dan studi literature aplikasi mobile library dan disajikan secara deskriptif dengan menjelaskan hasil observasi sesuai temuan di lapangan. Lembaga pendidikan sudah mulai siap dalam berinteraksi dengan perkembangan teknologi informasi hal tersebut terlihat dari sejauh ini sudah cukup banyak menyediakan / menghadirkan aplikasi mobile library di lingkungan pendidikan mereka baik itu dikalangan perguruan tinggi sampai Sekolah Menengah Pertama (SMP). Keyword: Perpustakaan mobile, Literasi informasi, literasi dijital. AbstrakInformation literacy is something that is very much needed for all academic circles or among ordinary people in increasing their ability in knowledge in information that is more recent or hot at this time. The birth of a digital literacy culture is in line with advances in information technology which makes it easy for the public to obtain digital information without having to think about the distance and location they seek to obtain information. The transformation of information retrieval in the information technology era produces a masterpiece that makes a change in the culture of information retrieval, which initially used print as a reference collection to become digital literacy and use digital books as a reference for digital information. The researcher uses a qualitative methodology, this research uses a qualitative descriptive. The method of data collection by researchers used an observation system for mobile library applications, interviews and literature studies of mobile library applications and presented descriptively by explaining the results of observations according to the findings in the field. Educational institutions have begun to be ready to interact with information technology developments, this can be seen from so far there have been quite a number of providing/presenting mobile library applications in their educational environment, both among colleges and junior high schools (SMP).Keyword: Mobile library, Information literacy, digital literacy.
Kompetensi Seorang Pustakawan Dalam Menguasai Teknologi Informasi Untuk Mengelola Perpustakaan Digital Pada Era 4.0
Authors: Julianti Siti Aminah 
Published: August 2024

AbstrakPerkembangan teknologi informasi yang maju semakin pesat, menyebabkan berbagai instansi atau lembaga mengubah cara kerja mereka dengan teknologi yang berbasis digital, termasuk perpustakaan. Ini menjadi tantangan bagi lembaga atau instansi perpustakaan untuk meningakatkan sumber daya manusia karyawannya yaitu pustakawan. Oleh karena itu, perlu dilakukan pelatihan kepada para staf pustakawan agar mereka menguasi kompetensi dan kemampuan terhadap teknologi informasi untuk memberikan pelayanan terbaik kepada pemustaka dengan membangun perpustakaan digital. Tujuan dari tulisan ini adalah memberikan gambaran terkait kompetensi yang harus dikuasai oleh pustakawan dalam mengelola perpustakaan digital di zaman serba canggih ini agar perpustakaan tersebut tidak tertinggal dan habis dimakan zaman.Kata Kunci: Kompetensi Pustakawan, Perpustakaan Digital, Pustakawan, Teknologi Informasi. AbstractThe development of advanced information technology is increasing rapidly, causing various agencies or institutions to change the way they work with digital-based technology, including libraries. This is a challenge for library institutions or agencies to improve the human resources of their employees, namely librarians. Therefore, it is necessary to conduct training for librarian staff so that they master the competence and ability of information technology to provide the best service to users by building digital libraries. The purpose of this paper is to provide an overview of the competencies that librarians must master in managing digital libraries in this sophisticated era so that these libraries are not left behind and run out of time.Keywords: Librarian Competence, Digital Library, Librarian, Information Technology.
Promosi Perpustakaan Melalui Bulletin Di Perpustakaan "HAMKA" SD Muhammadiyah Condongcatur : Best Practice
Authors: Hidayah Nurrohmah 
Published: August 2024

AbstrakTulisan ini bertujuan untuk menjelaskan pengembangan produk promosi di Perpustakaan SD Muhammadiyah Condongcatur, melalui pembuatan buletin perpustakaan. Dalam penelitian ini, penulis bertujuan untuk menjelaskan enam tahap dalam pelaksanaan program ini: 1) menganalisis kebutuhan pengguna, 2)membangun kemitraan, 3) mengembangkan kegiatan dan sumber daya, 4) pelaksanaan promosi, 4) evaluasi. Hasil dari penelitian ini adalah produk buletin yang dapat digunakan sebagai alat promosi perpustakaan dan sebagai kegiatan untuk meningkatkan minat baca dan tulis bagi semua sivitas sekolah. Program dalam penelitian ini perlu ditangani karena ada banyak perpustakaan sekolah dasar lain untuk mengembangkan promosi di tingkat sekolah dasar.Kata Kunci: Perpustakaan Sekolah, Promosi Perpustakaan AbstractThis paper aims to explain the development of promotional products in Library elementary Muhammadiyah Condongcatur, through the creation of library bulletins. In this study, the authors aim to explain the six stages in the implementation of this program: 1) analyze user needs, 2) build partnerships, 3) develop activities and resources, 4) implementation of promotion, 4) evaluation. The results of this study is a bulletin product that can be used as a library promotion tool and as an activity to increase interest in reading and writing for all school civitas. The program in this study needs to be addressed as there are many other elementary school libraries to develop promotion at the primary school level.Keywords: School Library, Library Promotion.
Perawatan Kulit Kering pada Lansia
Authors: Yulisa Dennely , Menaldi Sri Linuwih 
Published: August 2024

Kulit kering atau xerosis kutis merupakan kondisi kulit yang mengalami kekurangan kandungan air di stratum korneum. Kondisi tersebut sering terjadi pada lansia akibat menurunnya aktivitas kelenjar keringat, sebasea, gangguan keratinisasi serta menurunnya jumlah seramid dan natural mosturizing factor (NMF) atau kondisi penyakit lainnya. Kasus kulit kering di Indonesia dilaporkan pada tahun 2008 hingga 2013 di RSCM sebanyak 63,78%. Gejala kulit kering adalah gatal dengan lesi mulai dari eritema, skuama hingga berfisura yang predileksinya pada ekstensor tungkai bawah dan panggul. Perawatan kulit kering meliputi pemberian pelembab topikal, perubahan gaya hidup dan penyesuaian terhadap lingkungan. Penggunaan emolien dan petrolatum disarankan mengandung 10% urea atau 5% asam laktat digunakan dua kali sehari segera setelah mandi. Pemilihan sediaan pelembab menyesuaikan derajat xerosis dan kenyamanan pasien. Dianjurkan menghindari pelembab yang mengandung agen iritatif atau memicu sensitisasi kulit. Modifikasi kebiasaan seperti durasi mandi yang singkat, penggunaan sabun yang tepat dan kelembaban lingkungan juga penting bagi perawatan kulit kering.
Eco-Maqāṣid in Climate Change Campaigns: From an Ecolinguistics Study to the Philosophy of Islamic Law
Authors: Haris Arkin , Widodo Aris , Tantri Irma Dwi , Sarah Siti 
Published: August 2024

This article aims to uncover ‘eco-maqāṣid’, an Islamic legal philosophy related to environmental awareness. Using a multimodality approach, the study begins by understanding the textual and visual meaning of climate change campaigns with Islamic themes on the @greenpeace.id Instagram account. The data were further explored through ecolinguistic studies to reveal The Stories We Live By, Ecological Philosophy (ecosophy), and Maqāṣid al-Sharī’ah. The findings show that the type of story constructed through the representation of the relationship between images and text is predominantly in the category of Salience, highlighting the importance of maqāṣid principles to environmental aspects. The principle of hifz al-nafs supports the promotion of environmental sustainability to protect Muslim health from the impacts of climate change. Hifz al-māl plays a role in the efforts of mitigation and adaptation to the threats of climate change to protect the assets and economic well-being of Muslim communities. Hifz al-nasl is related to the sustainable prese­­­rvation of Islamic rituals, holidays, and cultural traditions. Meanwhile, hifz al-dīn is reflected in the endeavor to care for the environment as a religious duty manifested from Quranic verses and Hadith. Hifz al-‘aql resonates with strengthening environmental education through Ulama advice and Islamic ethics. Finally, all ḍarūriyyāt al-khams advocates for the protection of all elements in nature. This integration of maqāṣid into ecosophy illustrates how Islamic principles guide environmental management against climate change, creating a framework called ‘eco-maqāṣid’.