bluuebunny/crossref_metadata_2025_split huggingface dataset:
Staring into the abyss
Authors: Yu Xiangyao , Bezerra George , Pavlo Andrew , Devadas Srinivas , Stonebraker Michael 
Published: May 2015

Computer architectures are moving towards an era dominated by many-core machines with dozens or even hundreds of cores on a single chip. This unprecedented level of on-chip parallelism introduces a new dimension to scalability that current database management systems (DBMSs) were not designed for. In particular, as the number of cores increases, the problem of concurrency control becomes extremely challenging. With hundreds of threads running in parallel, the complexity of coordinating competing accesses to data will likely diminish the gains from increased core counts.
To better understand just how unprepared current DBMSs are for future CPU architectures, we performed an evaluation of concurrency control for on-line transaction processing (OLTP) workloads on many-core chips. We implemented seven concurrency control algorithms on a main-memory DBMS and using computer simulations scaled our system to 1024 cores. Our analysis shows that all algorithms fail to scale to this magnitude but for different reasons. In each case, we identify fundamental bottlenecks that are independent of the particular database implementation and argue that even state-of-the-art DBMSs suffer from these limitations. We conclude that rather than pursuing incremental solutions, many-core chips may require a completely redesigned DBMS architecture that is built from ground up and is tightly coupled with the hardware.
Divide & conquer-based inclusion dependency discovery
Authors: Papenbrock Thorsten , Kruse Sebastian , Quiané-Ruiz Jorge-Arnulfo , Naumann Felix 
Published: May 2015

The discovery of all inclusion dependencies (INDs) in a dataset is an important part of any data profiling effort. Apart from the detection of foreign key relationships, INDs can help to perform data integration, query optimization, integrity checking, or schema (re-)design. However, the detection of INDs gets harder as datasets become larger in terms of number of tuples as well as attributes.
To this end, we propose Binder, an IND detection system that is capable of detecting both unary and n-ary INDs. It is based on a divide & conquer approach, which allows to handle very large datasets -- an important property on the face of the ever increasing size of today's data. In contrast to most related works, we do not rely on existing database functionality nor assume that inspected datasets fit into main memory. This renders Binder an efficient and scalable competitor. Our exhaustive experimental evaluation shows the high superiority of Binder over the state-of-the-art in both unary (Spider) and n-ary (Mind) IND discovery. Binder is up to 26x faster than Spider and more than 2500x faster than Mind.
Effects of LEP, GYS1, MYOD1, and MYF5 polymorphisms on pig economic traits
Authors: Park Sang-Je , Ha Jeongim , Kim Il-Suk , Kwon Seul Gi , Hwang Jung Hye , Park Da Hye , Kang Deok Gyeong , Kim Tae Wan , Kim Sam Woong , Kim Chul Wook 
Published: May 2015

Abstract
In the present study, we examined the effect of single nucleotide polymorphisms (SNPs) of leptin (LEP), skeletal muscle glycogen synthase (GYS1), myogenic differentiation 1 (MYOD1), and myogenic factor 5 (MYF5) genes on economic trait association in pigs. LEP/HindIII, MYOD1/DdeI, MYF5/FokI, and GYS1/FokI genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) from 466 pigs comprised of Duroc, Landrace and Yorkshire breeds. The LEP/HindIII polymorphism differed significantly with respect to average daily gain (ADG) in Duroc pigs (P<0.05). However, the GYS1/FokI polymorphism was not significantly associated with any trait. The MYOD1/DdeI polymorphism was significantly associated with both ADG and meat percentage (MP) in Duroc pigs, and ADG, backfat thickness (BFT) and feed efficiency (FE) in Landrace pigs, whereas the MYOD1/DdeI polymorphism was not significantly associated with any trait in Yorkshire pigs. In addition, the MYF5/FokI polymorphism revealed a close relationship with ADG in Duroc pigs. In conclusion, we believe that the SNPs within LEP, MYOD1 and MYF5 in certain pig breeds play important roles as potential genetic markers for economic traits of pigs.
Cephalosporin resistant bacterial strains isolated from respiratory infections
Authors: Botnarciuc Mihaela , Stan Irina , Ispas Sorina 
Published: May 2015

Abstract
Objectives: The objective of the study is the evaluation of the actual resistance to second, third, and fourth generation cephalosporins over bacterial strains isolated from respiratory infections. The main causes for cephalosporin resistance of pathogenic and conditioned pathogen bacteria are: widespread usage, and impair immune response.
Materials and methods: The analyzed specimens were throat swabs and sputum, from adult patients. The tests were performed using disk diffusion technique. We tested the following cephalosporin: From second generation: cefuroxime axetil; from third generation: cefotaxime, ceftazidime, cefpodoxime; Combinations of cephalosporins and beta-lactamase inhibitors: cefotaxime + clavulanic acid; ceftazidim + clavulanic acid; From fourth generation: cefepime; and association cefepime and clavulanic acid.
Results: The following bacterial strains were isolated: Staphylococcus aureus, Streptococcus pneumoniae, Group C β-hemolytic Streptococcus, E. coli, Klebsiella pneumoniae and Proteus sp. The Group A. β-hemolytic Streptococcus isolated strains were not tested. For Staphylococcus aureus, E. coli, K. pneumoniae and Proteus, we found a high frequency resistance tocefuroxim, approximately 47%. Highest resistance to third generation cephalosporin was identified to E.coli and Klebsiella pneumoniae, especially resistant to cefotaxime, cefotaxime + clavulanic acid and ceftazidime.
Conclusions: Cefpodoxime can be considered as a first election antibiotic in treating upper and lower respiratory tract infections, due to the lowest level of bacterial strain resistance, approximately 10% of the third generation cephalosporines tested. Also, cefepime may be proper in treating severe respiratory tract infections, with resistant broad-spectrum antibiotics bacterial strains. In our trial, resistance to cefepime was to a minimum low, approximately 4%, represented by the E.coli strains.
Gastric primary non-Hodgkin lymphoma: a case report and literature review
Authors: Ghitoi Sinziana-Andra , Aşchie Mariana , Enciu Manuela , Cozaru Georgeta Camelia , Chisoi Anca 
Published: May 2015

Abstract
Non-Hodgkin malignant lymphomas represent a heterogeneous group of monoclonal tumors developing from cells belonging to the immune system. Primary gastric lymphomas are defined as those malignant limphoproliferative diseases whose initial symptoms are located in the stomach or tumor mass located in the stomach. This paper aims to present a new case of primary gastric non Hodgkin lymphoma diagnosed by histologic and immunohistochemical examination of a partial gastrectomy specimen. The patient is a 51-years old man with a history of smoking, hospitalized for asthenia, hematemesis and melena. Microscopically the tumor consisted of mature small lymphocytes admixed with plasmocitoid lymphocytes and mature plasmocytes. Some of the tumoral cells showed citoplasmatic pas positive inclusions. Immunohistochemical stains were strongly positive for CD20 and 30-40% positive for Ki67.Based on the clinical and histological findings, a diagnosis of gastric primary non-Hodgkin lymphoma was established.
Treatment of trochanteric fractures using the Gamma nail
Authors: Botnaru V. , Șerban Al. O. , Valcu Al. , Obadă B. 
Published: May 2015

Abstract
A retrospective study on 2 years and 4 months (April 2012 - August 2014) on 430 patients admitted with trochanteric fractures in our Clinic. The surgical indications depended on the patients age, degree of osteoporosis, level activity, associated pathologies and the anatomo-clinical particularity of the fractures. The fractures were operated with gamma nail. The surgery was done in the first 24-72 hours, patients were followed clinically and radiographically at 2, 4, 6 months postoperative. The age of the patients were between 28-95 years, female sex was predominant in 65% of case. It was reported a case of a fracture produced intraoperatory during progression of the nail, 11 bronhopulmonary complications, 5 phlebitis, 7 cases of hematoma after surgery, a case of pseudarthrosis with loosening of implant and 4 dead. There were no septic complications. Fractures consolidate within 12- 14 weeks. The results were appreciated according to fracture reduction, stability of implant, consolidation time and possibility of walking and weight bearing on operated limb.
Classification of persistent and long-standing persistent atrial fibrillation by means of surface electrocardiograms
Authors: Ortigosa Nuria , Fernández Carmen , Galbis Antonio , Cano Óscar 
Published: May 2015

Abstract
Atrial fibrillation, which is the most common cardiac arrhythmia, is typically classified into four clinical subtypes: paroxysmal, persistent, long-standing persistent and permanent. The ability to distinguish between them is of crucial significance in choosing the most suitable therapy for each patient. Nevertheless, classification is currently established once the natural history of the arrhythmia has been disclosed as it is not possible to make an early differentiation. This paper presents a novel method to discriminate persistent and long-standing atrial fibrillation patients by means of a time-frequency analysis of the surface electrocardiogram. Classification results provide approximately 75% accuracy when evaluating ECGs of consecutive unselected patients from a tertiary center and higher than 80% when patients are not under antiarrhythmic treatment or do not have structural heart disease (76% sensitivity and 88% specificity). Moreover, to our knowledge, this is the first study that discriminates between persistent and long-standing persistent subtypes in a heterogeneous population sample and without discontinuing antiarrhythmic therapy to patients. Thus, it can help clinicians to address the most suitable therapeutic approach for each patient.
Towards Successful Cloud Ordering Service
Authors: Chen Yan-Kwang , Chen Yi-Ju , Chiu Fei-Rung , Wang Cheng-Yi 
Published: May 2015

Abstract
Background: The rise of cloud services has led to a drastic growth of e-commerce and a greater investment in development of new cloud services systems by related industries. For SaaS developers, it is important to understand customer needs and make use of available resources at as early as the system design and development stage. Objectives: This study integrates E-commerce Systems (ECS) Success model and Importance-Performance Analysis (IPA) into empirical research of the critical factors for cloud ordering system success. Methods/Approach: A survey research is conducted to collect data on customer perceptions of the importance and performance of each attribute of the particular cloud ordering service. The sample is further divided according to the degree of use of online shopping into high-usage users and low-usage users in order to explore their views regarding the system and generate adequate coping strategies. Results: Developers of online ordering systems can refer to the important factors obtained in this study when planning strategies of product/service improvement. Conclusions: The approach proposed in this study can also be applied to evaluation of other kinds of cloud services systems.
How to Write and Publish A Scientific Paper: A Closer Look to Eastern European Economics, Business and Management Journals
Authors: Bach Mirjana Pejić 
Published: May 2015

Abstract
Background: Scientific research publishing carries significant role in the development of the society. Apart from the dissemination of knowledge, there are also motives for publication of scientific research results at the level of individual researchers. Objectives: The goal of the paper is to propose simple, yet highly applicable advice when pursuing the publication of a paper in a scientific journal providing a closer look to economics, business and management journals that focus on Eastern European countries. Methods/Approach: The 4 Cs model of scientific writing and publication is presented, based on four questions: (1) How to pick a topic relevant for publication?; (2) How to select a journal for possible publication?; (3) How to structure the paper in accordance with the IMRAD format?, and (4) How to efficiently write the paper? Results: Step-by-step application of the 4C’s model is presented in the paper with an outlook to economics, business and management journals that focus on Eastern European countries. Conclusions: Publication in a scientific journal is an important venue for scientific researchers. In preparing the presentation of the scientific research results for the publication, number of issues relating content, style, composition and presentation should be taken into account.
埋怨类话语标记语的语用功能与认知特征
Authors: 明强 周 
Published: May 2015

提要
埋怨类话语标记语是一种表示埋怨情绪的话语标记，主要有 “真是/也真是” “真是的/也真是的” “何必呢” “何苦呢” “至于吗” “你看你” “不是我说你” “不是我V你” “看/瞧你说的” “你这个/种人啊” “再怎么说” 等。埋怨类话语标记语可以提示所说话语具有埋怨的特征，其埋怨程度随语境、埋怨对象、埋怨内容等不同而有所不同。埋怨内容与埋怨情绪相匹配，埋怨情绪以埋怨类话语标记语来显现，埋怨情绪随埋怨对象发生变化，埋怨类话语标记语需依语境作出选择。埋怨类话语标记语的认知，关键也在于对埋怨情绪的把握，在认知结果上具有互通性、差异性和趋同性等特征。
First trimester PAPP-A2, PAPP-A and hCGβ in small-for-gestational-age pregnancies
Authors: Hansen Young Bae , Myrhøj Vibeke , Jørgensen Finn Stener , Oxvig Claus , Sørensen Steen 
Published: May 2015

AbstractPregnancy-associated plasma protein-A2 (PAPP-A2) is a recently discovered protease that cleaves a subset of insulin-like growth factor binding proteins (IGFBP). The molecular function suggests its involvement in the IGF system that is vital for fetal growth and development. Our objectives were to establish first trimester median curves of PAPP-A2, PAPP-A and hCGβ for singleton normal pregnancies and to investigate whether an altered level of one or more of the biomarkers is associated with small-for-gestational-age (SGA) neonates before and after stratification according to maternal hypertension and/or proteinuria.This was a case-control study based on 985 pregnant women delivering normal-weighted neonates and 170 pregnant women delivering SGA neonates. PAPP-A2 was measured by ELISA. PAPP-A and hCGβ were measured by an automatic analyzer. Median curves from 8+1 to 14+0 were established and all concentration values were converted to multiples of the median (MoM) values.Before stratification the SGA cases had unaffected PAPP-A2 MoM and hCGβ MoM levels but lower PAPP-A MoM compared with normal controls. After stratification the SGA normotensive subgroup had lower PAPP-A2 MoM and PAPP-A MoM levels than the normal normotensive subgroup. Severe preeclamptic women delivering SGA neonates had higher PAPP-A2 MoM compared to the normotensive women delivering SGA neonates.Pregnant women delivering SGA neonates did not have altered levels of PAPP-A2 or hCGβ but had lower PAPP-A level in the first trimester compared with pregnant women delivering normal-weighted neonates. Pregnancies complicated with severe preeclampsia and SGA may be associated with high PAPP-A2 level.
Exogenous hydrogen sulfide exhibits anti-cancer effects though p38 MAPK signaling pathway in C6 glioma cells
Authors: Zhao Lanfu , Wang Yuan , Yan Quan , Lv Wenhai , Zhang Yufu , He Shiming 
Published: May 2015

Abstract
It has been documented that H2S, in some types of cancer, promotes tumor proliferation, whereas, in the other types, it inhibits the tumor cell growth. In the present study, we investigated the anti-cancer effects and relevant mechanisms of NaHS in C6 glioma cells. C6 cells were subjected to different concentrations of NaHS, then cell viability and morphological changes were examined by MTT assay and Hoechst staining. The protein expression of Caspase-3, Bcl-2, Bax, p38 MAPK (mitogen-activated protein kinase), and p53 was measured by Western blotting. This work demonstrated that NaHS could reduce cell number and induce apoptosis of C6 gliomas cells. The protein expression of Caspase-3 and Bax was up-regulated, while the protein expression of Bcl-2 was down-regulated. Additionally, p38 MAPK and p53 were activated in response to NaHS. Moreover, p38 MAPK inhibitor, SB203580, counteracted the inhibitory effect of NaHS on C6 glioma cells. These data suggest that NaHS can effectively reduce cell number of C6 cells by triggering the apoptosis via Caspase-dependent pathway. p38 MAPK and p53 play an important role in NaHS-induced apoptosis in C6 cells. These findings imply that administration of NaHS may represent a new strategy for the treatment of glioma.
Simulator for Distribution Scheduling in Downstream
Authors: Heckl István , Borbás Péter István , Szombathelyi Béla , Frits Márton 
Published: May 2015

Abstract
A novel simulator for distribution scheduling in downstream of the oil industry is introduced in this work to identify inconsistencies in the proposed short term schedule. The simulation system is actively used in the MOL Plc which is a major regional oil company in Central Europe. It takes into account production and storage sites, tanks (mobile and immobile part), and of course the pipelines. The pipeline network features branching points, the pipe diameter may change between two sites, there are parallel pipelines between two sites, and the direction of a pipe can be reversed. Different products, next to each other, are transported through a single pipe. The movement of the product in the pipeline is driven by the recently pumped product. The exact locations of the products within the pipes are calculated by this custom simulator.
The simulation has three phases: providing the initial data and the input, such as the actual contents of the pipes, tanks, and the planned product transfers; the simulation itself; and the presentation of the results. The initial data come from human operators and other IT systems. The simulator highlights the potential error in the schedule. The changing content of each pipe and the levels of the tanks can be displayed. If inconsistency occurs, the schedule has to be modified and the simulation has to be restarted. The simulator is extended to be able to handle barge and train transportation, and spots errors regarding foreign inventory.
Online Algorithms for a Generalized Parallel Machine Scheduling Problem
Authors: Szalkai István , Dósa György 
Published: May 2015

Abstract
We consider different online algorithms for a generalized scheduling problem for parallel machines, described in details in the second section. This problem is the generalization of the classical parallel machine scheduling problem, when the makespan is minimized; in that case each job contains only one task. On the other hand, the problem in consideration is still a special version of the workflow scheduling problem. We present several heuristic algorithms and compare them by computer tests.
Wpływ wystąpienia incydentów „burzy elektrycznej” na jakość życia i aktywność fizyczną u pacjentów po implantacji kardiowertera- defibrylatora / The influence “electrical storm” incidents on the quality of life and physical activity in patients after cardioverter defibrillator implantation
Authors: Kazimierska Barbara , Suska-Bąk Natasza , Kowalik Ilona , Maciąg Aleksander , Smolis-Bąk Edyta 
Published: May 2015

Streszczenie
Wstęp: Celem pracy była ocena poziomu aktywności fizycznej, jakości życia oraz lęku, stresu i depresji u pacjentów po wszczepieniu kardiowertera-defibrylatora (ICD), u których wystąpił bądź nie incydent burzy elektrycznej związany z wielokrotnymi interwencjami ICD.
Materiał i metody: Przebadano 36 pacjentów z ICD w wieku od 39 do 83 lat. Pacjentów podzielono na dwie grupy: osoby u których wystąpił (Burza +) lub nie (Burza -) incydent burzy elektrycznej. Badano: poziom aktywności fizycznej, jakości życia oraz depresji, stresu i lęku.
Wyniki: W grupie Burza (+) znamiennie częściej występowały utraty przytomności przed wszczepieniem ICD i wyładowania po implantacji, niż w grupie Burza (-). Stwierdzono, iż w grupie Burza (+) u znamiennie większej ilości osob występowała obawa przed wyładowaniami, w porównaniu z grupą Burza (-). Istotnie większy był też u niej poziom lęku. W grupie Burza (+) występowały łagodne objawy depresyjne, poziom stresu był natomiast zbliżony w obu grupach. Badani nie różnili się pomiędzy sobą w większości parametrów jakości życia oraz całotygodniowej aktywności fizycznej.
Wnioski: 1.Występowanie incydentów burzy elektrycznej u pacjentów z ICD istotnie zwiększa poziomu lęku przed detekcją urządzenia, wpływa na występowanie łagodnych objawów depresyjnych. 2.Burza elektryczna nie rzutuje na wzrost poziomu odczuwanego stresu, ani też na całotygodniową aktywność fizyczną. 3. Burze elektryczne ograniczają wykonywanie pracy zawodowej i prac domowych.4.Częstsze utraty przytomności u pacjentów przed wszczepieniem ICD mogą wskazywać na zwiększenie częstotliwości burz elektrycznych pojawiających się po implantacji urządzenia.
European standards and North American practice parameters for skin prick testing panels in allergic rhinitis and asthma
Authors: Popescu Florin-Dan 
Published: May 2015

Abstract
According to the Global Allergy and Asthma European Network (GA²LEN), a pan-European skin prick test panel for the diagnosis of allergic rhinitis and asthma includes 18 aeroallergen extracts, supplemented if necessary for regional or for particular patient needs, while the Allergen Subcommittee and Immunotherapy Committee of the American Academy of Allergy, Asthma and Immunology (AAAAI) selected 36 major clinically relevant aeroallergens for North America.
Misdiagnosis of laryngeal sarcomatoid squamous cell carcinoma – case report
Authors: Csiszér Irén , Mocanu Simona , Budu Vlad , Neagos Adriana 
Published: May 2015

Abstract
BACKGROUND. Even if it is a rare variant growth pattern of squamous cell carcinoma, sarcomatoid carcinoma seems to have almost the same clinical manifestations and risk factors as conventional squamous cell carcinoma.
CASE REPORT. This paper presents a complex case of a 59-year-old female patient known with laryngeal papillomatosis, who presented in our Department for moderate to severe inspiratory dyspnea associated with dysphonia and difficulty in swallowing. We mention that the patient had been previously evaluated by a pneumologist for apnea, snoring and daytime sleepiness and diagnosed and treated for sleep apnea syndrome. Clinical, laboratory, imaging and pathologic examinations revealed the association of upper airway obstruction with laryngeal cancer. Surgical intervention consisted in total laryngectomy and selective neck dissection associated with permanent tracheotomy. The microscopic appearance was that of a bilateral transglottic sarcomatoid squamous cell carcinoma without metastasis in the right lymph node.
CONCLUSION. It is important to evaluate the clinical and imagistic status of patients with laryngeal tumors in order to make a correct decision concerning their treatment policy. We emphasize that cooperation between multiple departments is absolutely necessary in order to adequately resolve, explore, diagnose and treat patients with laryngeal pathology.