bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serotonergic antidepressants and increased bleeding risk in patients undergoing breast biopsy
Authors: Mahdanian Artin A. , Looper Karl J. , Bacon Simon L. , Mesurolle Benoit , Meterissian Sarkis H. , Rej Soham 
Published: October 2015

Objectives: Recent investigations have shown that serotonergic antidepressant (SAd) use may increase the risk of peri-operative bleeding events. Our objective was to evaluate the possibility of a similar association in patients undergoing radiologic breast biopsies. Methods: We used data from 3890 patients undergoing 6300 biopsy procedures between January 2011 and October 2014 in the Breast Clinic of McGill University Health Centre, Montreal, Canada. In this case-control study, cases were patients reported to have abnormal bleeding during their biopsy by board-certified radiologists. A control group of nonbleeders was selected using matching according to age and type of biopsy. The correlation between abnormal bleeding and SAd use was assessed using bivariate and multivariate statistical analyses. Results: There were 97 patients with abnormal bleeding and 137 matched controls; 10 bleeders (cases) were on SAds (7 citalopram, 3 paroxetine) while only 1 nonbleeder (control group) was on a SAd (low-dose sertraline, 25 mg/day). SAds were significantly associated with increased bleeding risk (10.3% versus 0.7%, Fisher’s Exact p = 0.001). Moreover, after adjusting for confounding factors (age, type of biopsy, size of biopsy, needle caliber, pathology result and nonsteroidal anti-inflammatory drug use, multivariate logistic regression confirmed that SAds were associated with elevated bleeding risk (16.2, 95% confidence interval 1.87–140.1, p = 0.01). Conclusions: This is the first study demonstrating increased bleeding events in breast biopsy patients using SAds. Clinicians should be aware that SAds may be associated with peri-operative bleeding risk, even in relatively minor procedures such as breast biopsies.
Oral sucrose for heel lance enhances adenosine triphosphate use in preterm neonates with respiratory distress
Authors: Angeles Danilyn M , Asmerom Yayesh , Boskovic Danilo S , Slater Laurel , Bacot-Carter Sharon , Bahjri Khaled , Mukasa Joseph , Holden Megan , Fayard Elba 
Published: October 2015

Objective: To examine the effects of oral sucrose on procedural pain, and on biochemical markers of adenosine triphosphate utilization and oxidative stress in preterm neonates with mild to moderate respiratory distress. Study design: Preterm neonates with a clinically required heel lance that met study criteria (n = 49) were randomized into three groups: (1) control (n = 24), (2) heel lance treated with placebo and non-nutritive sucking (n = 15) and (3) heel lance treated with sucrose and non-nutritive sucking (n = 10). Plasma markers of adenosine triphosphate degradation (hypoxanthine, xanthine and uric acid) and oxidative stress (allantoin) were measured before and after the heel lance. Pain was measured using the Premature Infant Pain Profile. Data were analyzed using repeated measures analysis of variance, chi-square and one-way analysis of variance. Results: We found that in preterm neonates who were intubated and/or were receiving ⩾30% FiO2, a single dose of oral sucrose given before a heel lance significantly increased markers of adenosine triphosphate use. Conclusion: We found that oral sucrose enhanced adenosine triphosphate use in neonates who were intubated and/or were receiving ⩾30% FiO2. Although oral sucrose decreased pain scores, our data suggest that it also increased energy use as evidenced by increased plasma markers of adenosine triphosphate utilization. These effects of sucrose, specifically the fructose component, on adenosine triphosphate metabolism warrant further investigation.
Single high dose gentamicin for perioperative prophylaxis in orthopedic surgery: Evaluation of nephrotoxicity
Authors: Dubrovskaya Yanina , Tejada Rainer , Bosco Joseph , Stachel Anna , Chen Donald , Feng Melinda , Rosenberg Andrew , Phillips Michael 
Published: October 2015

Background: Recent studies described an increase in acute kidney injury when high dose gentamicin was included in perioperative prophylaxis for orthopedic surgeries. To this effect, we compared the rate of nephrotoxicity for selected orthopedic surgeries where gentamicin was included (Gentamicin Group) to those where it was not included (Control Group) for perioperative prophylaxis and evaluated risk factors for nephrotoxicity. Methods: Spine, hip and knee surgeries performed between April 2011 and December 2013 were reviewed retrospectively. Gentamicin was given to eligible patients based on age, weight and Creatinine Clearance. Nephrotoxicity was assessed using Risk, Injury, Failure, Loss, End-stage kidney disease (RIFLE) criteria. Results: Among selected surgeries (N = 1590 in Gentamicin Group: hip = 926, spine = 600, knee = 64; N = 2587 in Control Group: hip = 980, spine = 902, knee = 705), patients’ body weight, serum creatinine, comorbidities and surgery duration were similar in Gentamicin Group and Control Group. Gentamicin median dose was 4.5 mg/kg of dosing weight. Nephrotoxicity rate was 2.5% in Gentamicin Group and 1.8% in Control Group, p = 0.17. Most cases of nephrotoxicity were Risk category by RIFLE criteria (67% in Gentamicin Group and 72% in Control Group, p = 0.49). In logistic regression, risk factors for nephrotoxicity were hospital stay >1 day prior to surgery (odds ratio = 8.1; 95% confidence interval = 2.25–28.97, p = 0.001), knee or hip surgery (odds ratio = 4.7; 95% confidence interval = 2.9–9.48, p = 0.0005) and diabetes (odds ratio = 1.95; 95% confidence interval = 1.13–3.35, p = 0.016). Receipt of gentamicin was not an independent predictor of nephrotoxicity (odds ratio = 1.5; 95% confidence interval = 0.97–2.35, p = 0.07). Conclusion: In this cohort, rate of nephrotoxicity was similar between Gentamicin Group and Control Group. Single high dose gentamicin is a safe and acceptable option for perioperative prophylaxis in eligible patients undergoing orthopedic surgeries.
Treating hepatitis C in American Indians/Alaskan Natives: A survey of Project ECHO® (Extension for Community Healthcare Outcomes) utilization by Indian Health Service providers
Authors: Pindyck Talia , Kalishman Summers , Flatow-Trujillo Lainey , Thornton Karla 
Published: October 2015

Background: American Indians/Alaskan Natives have a high mortality associated with hepatitis C virus, yet treatment rates are low. The ECHO (Extension for Community Healthcare Outcomes) model™, a videoconferencing technology for primary care providers, is underutilized at Indian Health Service facilities. Purpose: To ascertain Indian Health Service providers’ benefit of and barriers to utilizing hepatitis C virus TeleECHO clinics. Methods: We electronically sent an Active Participant Survey to Indian Health Service providers utilizing hepatitis C virus TeleECHO clinic and a Non-Participant Survey to other Indian Health Service providers interested in this clinic. Results: In total, 100% of Active Participant Survey respondents perceive moderate to major benefit of hepatitis C virus TeleECHO clinic in managing hepatitis C virus, and 67% of Non-Participant Survey respondents reported lack of administrative time as the major barrier to utilizing this resource. Conclusion: Indian Health Service providers participating in hepatitis C virus TeleECHO clinic perceive this resource as highly beneficial, but widespread utilization may be impractical without allocating time for participation.
Pediatric chronic myeloid leukemia is a unique disease that requires a different approach
Authors: Hijiya Nobuko , Schultz Kirk R. , Metzler Markus , Millot Frederic , Suttorp Meinolf 
Published: October 2015

AbstractChronic myelogenous leukemia (CML) in children is relatively rare. Because of a lack of robust clinical study evidence, management of CML in children is not standardized and often follows guidelines developed for adults. Children and young adults tend to have a more aggressive clinical presentation than older adults, and prognostic scores for adult CML do not apply to children. CML in children has been considered to have the same biology as in adults, but recent data indicate that some genetic differences exist in pediatric and adult CML. Because children with CML may receive tyrosine kinase inhibitor (TKI) therapy for many decades, and are exposed to TKIs during a period of active growth, morbidities in children with CML may be distinct from those in adults and require careful monitoring. Aggressive strategies, such as eradication of CML stem cells with limited duration and intensive regimens of chemotherapy and TKIs, may be more advantageous in children as a way to avoid lifelong exposure to TKIs and their associated adverse effects. Blood and marrow transplantation in pediatric CML is currently indicated only for recurrent progressive disease, and the acute and long-term toxicities of this option should be carefully evaluated against the complications associated with lifelong use of TKIs.
Genericity and porosity in fixed point theory: a survey of recent results
Authors: Reich Simeon , Zaslavski Alexander J 
Published: October 2015

AbstractWe survey recent results regarding genericity and porosity in fixed point theory. These results concern, inter alia, infinite products, nonexpansive mappings, approximate fixed points, contractive mappings, bounded linear regularity, set-valued mappings, holomorphic mappings and weak ergodic theorems. We consider both normed linear spaces and hyperbolic metric spaces.
A topological degree for operators of generalized $(S_{+})$ type
Authors: Kim In-Sook , Hong Suk-Joon 
Published: October 2015

AbstractAs an extension of the Leray-Schauder degree, we introduce a topological degree theory for a class of demicontinuous operators of generalized $(S_{+})$
(

S
+

)
type in real reflexive Banach spaces, based on the recent Berkovits degree. Using the degree theory, we show that the Borsuk theorem holds true for this class. Moreover, we study the Dirichlet boundary value problem involving the p-Laplacian by way of an abstract Hammerstein equation.
Genome sequence of Oceanobacillus picturae strain S1, an halophilic bacterium first isolated in human gut
Authors: Lagier Jean-Christophe , Khelaifia Saber , Azhar Esam Ibraheem , Croce Olivier , Bibi Fehmida , Jiman-Fatani Asif Ahmad , Yasir Muhammad , Helaby Huda Ben , Robert Catherine , Fournier Pierre-Edouard , Raoult Didier 
Published: October 2015

AbstractOceanobacillus picturae is a strain of a moderately halophilic bacterium, first isolated from a mural painting. We demonstrate, for the first time, the culture of human Oceanobacillus picturae, strain S1T, whose genome is described here, from a stool sample collected from a 25-year-old Saoudian healthy individual. We used a slightly modified standard culture medium adding 100 g/L of NaCl. We provide a short description of this strain including its MALDI-TOF spectrum, the main identification tool currently used in clinical microbiology. The 3,675,175 bp long genome exhibits a G + C content of 39.15 % and contains 3666 protein-coding and 157 RNA genes. The draft genome sequence of Oceanobacillus picturae has a similar size to the Oceanobacillus kimchii (respectively 3.67 Mb versus 3.83 Mb). The G + C content was higher compared with Oceanobacillus kimchii (respectively 39.15 % and 35.2 %). Oceanobacillus picturae shared almost identical number of genes (3823 genes versus 3879 genes), with a similar ratio of genes per Mb (1041 genes/Mb versus 1012 genes/Mb).The genome sequencing of Oceanobacillus picturae strain S1 isolated for the first time in a human, will be added to the 778 genome projects from the gastrointestinal tract listed by the international consortium Human Microbiome Project.
Global Practice and Efficiency of Multidisciplinary Tumor Boards: Results of an American Society of Clinical Oncology International Survey
Authors: El Saghir Nagi S. , Charara Raghid N. , Kreidieh Firas Y. , Eaton Vanessa , Litvin Kate , Farhat Rania A. , Khoury Katia E. , Breidy Juliana , Tamim Hani , Eid Toufic A. 
Published: October 2015

Purpose Multidisciplinary tumor boards (MDTBs) are universally recommended, but recent literature has challenged their efficiency. Methods The American Society of Clinical Oncology (ASCO) conducted a survey of a randomly selected cohort of international ASCO members. The survey was built on SurveyMonkey and was sent via e-mail to a sample of 5,357 members. Results In all, 501 ASCO members practicing outside the United States responded, and 86% of them participated in MDTBs at their own institutions. Those who attended represented a variety of disciplines in 70% to 86% of all MDTBs. The majority of MDTBs held weekly specialty and/or general meetings. Eighty-nine percent of 409 respondents attended for advice on treatment decisions. Survey respondents reported changes of 1% to 25% in treatment plans for 44% to 49% of patients with breast cancer and in 47% to 50% of patients with colorectal cancer. They reported 25% to 50% changes in surgery type and/or treatment plans for 14% to 21% of patients with breast cancer and 12% to 18% of patients with colorectal cancer. Of the 430 respondents 96% said overall benefit to patients was worth the time and effort spent at MDTBs, and 96% said that MDTBs have teaching value. Mini tumor boards held with whatever types of specialists were available were considered valid. In all, 94.8% (425 of 448) said that MDTBs should be required in institutions in which patients with cancer are treated. Conclusion MDTBs are commonplace worldwide. A majority of respondents attend them to obtain recommendations, and they report changes in patient management. Change occurred more frequently with nonmedical oncologists and with physicians who had less than 15 years in practice. MDTBs helped practitioners make management decisions. Mini tumor boards may improve time efficiency and are favored when the full team is not available. Suggestions for improving MDTBs included making them more efficient, better selection and preparation of cases, choosing an effective team leader, and improving how time is used, but more research is needed on ways to improve the efficiency of MDTBs.
Compliance With Neoadjuvant Chemotherapy in T4 Oral Cancers: Place, Person, Socioeconomic Status, or Assistance
Authors: Patil Vijay M. , Noronha Vanita , Joshi Amit , Muddu Vamshi , Dhumal Sachin , Bhattacharjee Atanu , Prabhash Kumar 
Published: October 2015

Purpose Approximately 15% to 20% of our patients with head and neck cancer receiving neoadjuvant chemotherapy (NACT) discontinue therapy because of various nonmedical reasons. We sought to analyze the factors associated with treatment default and noncompliance among these patients. Patients and Methods We performed a retrospective analysis of patients with T4 oral cancer treated with NACT between January 2011 and December 2012. We included patients who discontinued treatment for nonmedical reasons before the second cycle of NACT. The factors analyzed were income, education, socioeconomic status, age, sex, place of residence, habits, and payment pattern (government supported or personal capacity). Pearson χ2 test was used to identify significant factors associated with noncompliance. Results Of 486 patients, 91 patients (18.7%) were noncompliant. Percentages of noncompliant patients in the age groups < 30, between 30 and 60, and > 60 years were 25.0%, 17.4%, and 25.5%, respectively (P = .27). Percentages of noncompliance in patients residing within the city, same state, or different state were 20.7%, 20.9%, and 17.1%, respectively (P = .44). Noncompliance rates were 20.3%, 15.7%, 18.1%, and 22.5% in upper middle, lower middle, upper lower, and lower economic strata, respectively (P = .60). Similarly, there was no significant difference in noncompliance according to occupation, education level, payment pattern, sex, or habits. Conclusion Our analysis failed to identify any specific significant factor associated with noncompliance with NACT among our patients with T4 oral cancers.
Synthesis and Photophysical Properties of 9,10-Bis(3-aryl-2-naphthyl)anthracenes
Authors: Umeda Rui , Kimura Masahiro , Tobe Yoshito , Nishiyama Yutaka 
Published: October 2015

Abstract
The 9,10-bis(3-aryl-2-naphthyl)anthracenes 3 were prepared by the benzannulation reaction of 2-(phenylethynyl)benzaldehyde (1) and the corresponding 9,10-bis(arylethynyl)anthracenes 2 in the presence of Cu or Re catalyst and trichloroacetic acid. The photophysical properties of 3 in solutions were investigated.
Ecological perspectives and children’s use of the Internet: exploring micro to macro level analysis
Authors: O’Neill Brian 
Published: October 2015

Igivanad arutelud, milles käsitletakse laste kokkupuudet meediatehnoloogiaga, toovad kommunikatsiooni ja meediauuringute suunal esile erimeelsusi ja vaidlusi põhjustanud pikaajalise traditsiooni. Olgugi et meediatarbimise mõju lastele on uuritud juba ringhäälingu algusaegadest peale, on selle üle endiselt vähe teoretiseeritud ja seda on kirjanduses harva käsitletud, samuti on see meediapoliitika debattides pälvinud vaid vähest mõistmist. Laste ja internetiuuringute puhul on vanad vaidlused süvenenud. Lähtudes ühelt poolt hoiatavatest teadetest riskide, ülemäärase arvutikasutuse ja selle kahjuliku mõju kohta ning teiselt poolt kiidu laulust "digimaailma päriselanikele" ja tehnoloogia võimele muuta maailma, seadis EU Kids Online endale eesmärgiks koguda andmeid, mis aitavad luua terviklikumat pilti veebikeskkonnast, milles noored tegutsevad. Siinses artiklis paigutan selle valdkonna tööd ökoloogilisse raamistikku, lähtudes nii Bronfenbrenneri bioökoloogilisest käsitlusviisist, mis on olnud tähtsal kohal uutes lapsepõlve sotsioloogilistes käsitlustes, kui ka üldisemalt defineeritud meediaökoloogia teoreetilisest raamistikust. Viimast seostatakse peamiselt McLuhani ja hiljem Postmani töödega, kus kirjeldatakse meediakeskkonda kui keerulise vastastikuse mõjutamise süsteemi tehnoloogia ja ühiskonna vahel, kus mitmesugused suhtlusviisid ja vahendatud vastastikune mõjutamine kujundavad oluliselt inimkäitumist ja ühiskondlikku elu. Selline vaatenurk on mõningate põletavate probleemidega tegelemisel väga vajalik, kui kõne all on teadusuuringutel põhinev poliitikakujundamine, mis on seotud interneti haldamise ja reguleerimisega ning noorte kaitsmisega internetikeskkonnas.
Full text
Ecological perspectives and children’s use of the Internet: exploring micro to macro level analysis
Authors: O’Neill Brian 
Published: October 2015

Age-old debates on children’s encounters with media technologies reveal a long, fractured and contentious tradition within communication and media studies. Despite the fact there have been studies of effects of media use by children since the earliest days of broadcasting, the subject remains under-theorised, poorly represented in the literature and not widely understood in media policy debates. Old debates have intensified in relation to the study of children and the internet. Pitted between alarmist accounts of risks, excessive use and harmful effects on the one hand and the many accounts about "digital natives" and the transformational power of technology is the empirical project – represented by EU Kids Online among others – of building an evidence base for understanding the evolving environment for youth online engagement. In this paper, I situate that body of work in an ecological context, both in the sense of the Bronfenbrenner’s bio-ecological model that has been so important in the new sociology of childhood, as well as in the more loosely defined theoretical approach of media ecology. The latter tradition, associated primarily with McLuhan and later Postman, frames the media environment as a complex interplay between technology and society in which modes of communication and mediated interaction fundamentally shape human behaviour and social life. These strands offer the basis for framing some of the issues of evidence-based policymaking relating to internet governance, regulation and youth protection online.
Parents’ opinions on parental mediation strategies used to instruct toddlers
Authors: Nevski Elyna , Vinter Kristi 
Published: October 2015

Väikelaste kokkupuude puutetundlike ekraanidega algab juba imikueas ning esimese eluaasta jooksul saavad lastest regulaarsed meediatarbijad. Paraku ei ole ühest vastust, mil määral väikelapsed on suutelised puutetundliku ekraani vahendusel õppima ning kui palju nad vajavad selleks lapsevanema kaasabi. Kuna laste tehnoloogiakasutus on mõjutatud lapsevanemate uskumustest, on nende uurimine oluline. Uurimuse eesmärk on välja selgitada Eesti lapsevanemate arvamused puutetundlike seadmete kasutamise vajalikkuse kohta ning nende hinnangud juhendamisstrateegiatele nutiseadme kasutamisel väikelapseeas. Uuringust, milles osales 400 lapsevanemat, kellel on laps(i) vanuses 0–36 kuud, selgub, et peredes, kus vanemad seavad laste nutiseadmete kasutamisele nii aja- kui ka sisupiiranguid, kasutavad lapsed nutiseadmeid sagedamini kui peredes, kus piiranguid ei seata. Lapsevanemad näevad nutiseadme kasutamise eelisena seda, et laps õpib uusi oskusi, saab uusi teadmisi ning seade pakub lapsele meelelahutust. Nutiseadme võimaldamise peamine põhjus on vanemate võimalus teha samal ajal oma asjatoimetusi. 0–3aastaste laste vanemate seas pole aga välja kujunenud selgeid ja konkreetseid juhendamisstrateegiaid, pigem kasutavad vanemad nii aktiivse kui ka keelava juhendamise elemente korraga ja omavahel seotult. Tulemustest ilmneb, et puutetundliku ekraani kasutamise sagedus suureneb lapse vanuse kasvades. Samas ei mõjuta lapsevanemate haridustase nutiseadme kasutamise sagedust ega vanemlikke juhendamisstrateegiaid.
Summary
Classroom strategies in teaching the media
Authors: Kupiainen Reijo 
Published: October 2015

Artikkel põhineb minu raamatu "Meedia ja digitaalne kirjaoskus keskkoolis" ("Media and digital literacies in secondary school") (2013) 5. peatükil. Artikli tarbeks olen seda peatükki veidi lühendanud ja ümber sõnastanud. Keskendun mitmesugustele õppestrateegiatele, mida jälgiti 2009/2010. õppeaastal ühes Soome keskkoolis toimunud etnograafilise kooliuuringu käigus. Uuring näitab, et meediahariduse peamise strateegiana kasutavad õpetajad analüüsi ja meediatekstide loomist. Artiklis esitan selliste strateegiate näidetena reklaamiprojekti, seebiooperi loomise, animatsiooniprojekti, eluloo koostamise ja ajalehe esikaane kujundamise eri õppekeskkondades. Kõik näited viitavad sellele, et meediaharidus peab rajama tugeva silla noorte ja koolikultuuri vahele ning koolis kasutatav tehnoloogia peab õppesisuga kaasas käima.
Full text
The role of Estonian teachers in the social mediation of children’s internet use
Authors: Soo Kadri , Kalmus Veronika , Ainsaar Mare 
Published: October 2015

Õpetajatel on oluline roll laste ettevalmistamisel internetimaailmas toimetulekuks. Artiklis analüüsitakse Eesti õpetajate tegevust 9–16aastaste laste internetikasutuse sotsiaalses vahendamises, mille mõõtmiseks kasutati kaheksat tunnust EU Kids Online’i uuringust. Tulemused näitavad, et enamik Eesti õpetajatest on õpilaste internetikasutust sotsiaalselt vahendanud: üksnes 13% lastest ei suutnud meenutada, et nad oleks õpetajatelt kunagi juhiseid või informatsiooni saanud. Peamised erinevused Eesti õpetajate tegevuses ilmnesid keele ja asula suuruse puhul. Uuring lubab väita, et eesti keelt rääkivate ja väikestest asulatest pärit laste õpetajad vahendavad laste internetitegevusi aktiivsemalt ja mitmekülgsemalt ning pakuvad internetiohtude korral rohkem nõuandeid. See, kuidas on õpetajate tegevus ja laste kokkupuude internetiohtudega omavahel seotud, erineb vanuseja keelerühmiti. Internetis kahju kogemine ei ole seotud õpetajatepoolse sotsiaalse vahendamisega.
Summary