bluuebunny/crossref_metadata_2025_split huggingface dataset:
cAMP ameliorates inflammation by modulation of macrophage receptor for advanced glycation end-products
Authors: Motoyoshi So , Yamamoto Yasuhiko , Munesue Seiichi , Igawa Hirobumi , Harashima Ai , Saito Hidehito , Han Dong , Watanabe Takuo , Sato Hiroshi , Yamamoto Hiroshi 
Published: July 2014

Clarification of the roles of PAMPs (pathogen-associated molecular patterns) and DAMPs (damage-associated molecular patterns) is indispensable for therapeutic strategies against various inflammatory diseases. RAGE (receptor for advanced glycation end-products) is one of the PRRs (pattern recognition receptors) and has been implicated in autoimmune and inflammatory diseases. Effective remedies targeting RAGE are required for the diseases. In the present study, we show that cAMP-induced modulation of the RAGE isoform in macrophages can control the inflammatory state in both in vitro and in vivo experimental conditions. The RAGE ligand S100B stimulated MCP-1 (monocyte chemoattractant protein-1) secretion from peritoneal macrophages, but cAMP elevation suppressed it by converting the RAGE isoform from a membrane-bound into a soluble form. This shedding is the result of ectodomain cleavage of mRAGE (membrane-bound RAGE) by MMP9 (matrix metalloproteinase 9). Furthermore, forskolin significantly inhibited peritoneal macrophage accumulation in a mouse S100B-induced peritonitis model. These results suggest that cAMP serves as a negative regulator of ligand–RAGE signalling and macrophage recruitment by mRAGE down-regulation and formation of decoys as soluble receptors. The present study should deepen our understanding of the pathogenesis of RAGE-mediated tissue derangement and provide new clues for overcoming RAGE-related inflammatory diseases.
Novel humanD-amino acid oxidase inhibitors stabilize an active-site lid-open conformation
Authors: Terry-Lorenzo Ryan T. , Chun Lawrence E. , Brown Scott P. , Heffernan Michele L. R. , Fang Q. Kevin , Orsini Michael A. , Pollegioni Loredano , Hardy Larry W. , Spear Kerry L. , Large Thomas H. 
Published: July 2014

The NMDAR (N-methyl-D-aspartate receptor) is a central regulator of synaptic plasticity and learning and memory. hDAAO (human D-amino acid oxidase) indirectly reduces NMDAR activity by degrading the NMDAR co-agonist D-serine. Since NMDAR hypofunction is thought to be a foundational defect in schizophrenia, hDAAO inhibitors have potential as treatments for schizophrenia and other nervous system disorders. Here, we sought to identify novel chemicals that inhibit hDAAO activity. We used computational tools to design a focused, purchasable library of compounds. After screening this library for hDAAO inhibition, we identified the structurally novel compound, ‘compound 2’ [3-(7-hydroxy-2-oxo-4-phenyl-2H-chromen-6-yl)propanoic acid], which displayed low nM hDAAO inhibitory potency (Ki=7 nM). Although the library was expected to enrich for compounds that were competitive for both D-serine and FAD, compound 2 actually was FAD uncompetitive, much like canonical hDAAO inhibitors such as benzoic acid. Compound 2 and an analog were independently co-crystalized with hDAAO. These compounds stabilized a novel conformation of hDAAO in which the active-site lid was in an open position. These results confirm previous hypotheses regarding active-site lid flexibility of mammalian D-amino acid oxidases and could assist in the design of the next generation of hDAAO inhibitors.
Describing Treatment Intensity in Milieu Teaching Interventions for Children With Developmental Disabilities: A Review
Authors: Parker-McGowan Quannah , Chen Mo , Reichle Joe , Pandit Shivani , Johnson LeAnne , Kreibich Shelley 
Published: July 2014

Purpose
This investigation aimed to apply the dosage framework proposed by Warren, Fey, and Yoder (2007) to variations of milieu language teaching intervention strategies to explore how each of the dosage parameters (i.e., dose, dose form, dose frequency, total duration, and cumulative intervention intensity) was reported in the located empirically based applications with learners between birth and 23 years of age.

Method
A systematic search located existing studies that implemented a milieu teaching intervention for children with developmental disabilities. Dosage data were then extracted from 42 studies along with study characteristics and participant characteristics.

Results
Only 37.8% of empirical investigations provided a clear definition of treatment intensity and reported the full range of dosage parameters, thus making it difficult to compare the results across investigations. Of the investigations that reported on all dosage parameters, the majority were single-case design as opposed to group design studies.

Conclusions
Given the limited reporting of dosage parameters in existing studies, there is a need for closer attention to reporting this information in early communication intervention protocols. Replication and customization of interventions for learners experiencing developmental disabilities will only be possible with additional empirical examination of dosage parameters.
Proteome-wide remodeling of protein location and function by stress
Authors: Lee KiYoung , Sung Min-Kyung , Kim Jihyun , Kim Kyung , Byun Junghyun , Paik Hyojung , Kim Bongkeun , Huh Won-Ki , Ideker Trey 
Published: July 2014

Significance
Protein location and function are dependent on diverse cell states. We develop a conditional function predictor (CoFP) for proteome-wide prediction of condition-specific locations and functions of proteins. In addition to highly accurate retrieval of condition-dependent locations and functions in individual conditions, CoFP successfully discovers dynamic function changes of yeast proteins, including Tsr1, Caf120, Dip5, Skg6, Lte1, and Nnf2, under DNA-damaging stresses. Beyond specific predictions, CoFP reveals a global landscape of changes in protein location and function, highlighting a surprising number of proteins that translocate from the mitochondria to the nucleus or from endoplasmic reticulum to Golgi apparatus under stress. CoFP has the potential to discover previously unidentified condition-specific locations and functions under diverse conditions of cellular growth.
ASP-G: an ASP-based method for finding attractors in genetic regulatory networks
Authors: Mushthofa Mushthofa , Torres Gustavo , Van de Peer Yves , Marchal Kathleen , De Cock Martine 
Published: July 2014

AbstractMotivation: Boolean network models are suitable to simulate GRNs in the absence of detailed kinetic information. However, reducing the biological reality implies making assumptions on how genes interact (interaction rules) and how their state is updated during the simulation (update scheme). The exact choice of the assumptions largely determines the outcome of the simulations. In most cases, however, the biologically correct assumptions are unknown. An ideal simulation thus implies testing different rules and schemes to determine those that best capture an observed biological phenomenon. This is not trivial because most current methods to simulate Boolean network models of GRNs and to compute their attractors impose specific assumptions that cannot be easily altered, as they are built into the system.Results: To allow for a more flexible simulation framework, we developed ASP-G. We show the correctness of ASP-G in simulating Boolean network models and obtaining attractors under different assumptions by successfully recapitulating the detection of attractors of previously published studies. We also provide an example of how performing simulation of network models under different settings help determine the assumptions under which a certain conclusion holds. The main added value of ASP-G is in its modularity and declarativity, making it more flexible and less error-prone than traditional approaches. The declarative nature of ASP-G comes at the expense of being slower than the more dedicated systems but still achieves a good efficiency with respect to computational time.Availability and implementation: The source code of ASP-G is available at http://bioinformatics.intec.ugent.be/kmarchal/Supplementary_Information_Musthofa_2014/asp-g.zip .Contact : Kathleen.Marchal@UGent.be or Martine.DeCock@UGent.beSupplementary information: Supplementary data are available at Bioinformatics online.
Mapping inshore fishing activity using aerial, land, and vessel-based sighting information
Authors: Breen Patricia , Vanstaen Koen , Clark Robert W. E. 
Published: July 2014

Abstract
Information on the distribution and intensity of inshore fishing activity is needed to inform marine spatial planning and to assess fisheries interactions with the environment and other industries. Although fishing vessels under 15 m (overall length) account for 98.4% (2011 value) by the number of the European fleet, information on inshore fishing activity in Europe is very limited as there is no statutory satellite monitoring of smaller vessels (&lt;15 m length before 2012, &lt;12 m thereafter). Here, we develop, present, and apply a method which uses sightings-per-unit-effort (SPUE) estimates calculated from fisheries enforcement data to describe the distribution and intensity of inshore fishing activity off the coasts of England and Wales. For the larger inshore vessels, the SPUE estimates of activity were validated with vessel monitoring system (VMS) data and showed good agreement at the scale of analysis. Fishing activity estimates from SPUE are presented with an assessment of uncertainty, to account for spatial differences in enforcement activity. Our estimates of the distribution and intensity of inshore fishing activity and will complement estimates of offshore fishing activity based on VMS.
Augustus
Authors: Cooley Alison E. 
Published: July 2014

Augustus, famous as Rome’s first emperor, came to power in the aftermath of his defeat of Antony and Cleopatra. The benefit of hindsight allows us to view him as the founder of a new political system at Rome, known as the Principate. This neat summary obscures the fact that the period of Augustus’s rule was one of experimentation and innovation, exploring what the place of Augustus and his family should be within the structures of Roman society. The period is distinctive both for its innovative approach toward visual and material culture, notably art and architecture, coins, and inscriptions, and for claims to be restoring traditional Roman virtues, particularly in the sphere of religion. It also produced the Golden Age of Latin poetry, represented especially by Virgil, Propertius, Horace, and Ovid. Their works give insights into the moral and emotional compass of their world, engaging with public life and politics, but not in the form of propaganda. The whole of Roman society was restructured during this period. The introduction of an imperial court, with domus Augusta (“Augustan household,” i.e., the emperor and his relations) and familia Caesaris (slaves and freedmen associated with the emperor and his family) at its center, produced new structures of administration and government, while existing bodies, notably the Senate and equestrian order, were overhauled and their roles redefined. New laws on marriage, adultery, and the manumission of slaves were introduced to maintain the quality of the Roman citizen body. Financial reforms included the introduction of new coinage, setting up a new state mint at Lugdunum, and the establishment of a military treasury in Rome. Colonies were founded in many parts of the empire, and cities in both Italy and the provinces experienced a striking phase of monumental development, while the appearance of the city of Rome itself was radically modified, with particular emphasis on honoring the gods and providing amenities for the plebs. These benefits arose from the long period of peace ushered in by Augustus ending decades of civil wars, but the outbreak of peace did not exclude ongoing military campaigns beyond Italy. Augustus claimed at the end of his life that he had conquered the whole known world. Membership in the Roman army became a profession, bound to Augustus, who increasingly monopolized traditional military honors. By the time Augustus died in 14 ce, society at Rome, in Italy, and in the provinces had been radically transformed.
It Happened One Night
Authors: Mizejewski Linda 
Published: July 2014

The low-budget sleeper It Happened One Night (1934), directed by Frank Capra (b. 1897–d. 1991) was the first film to sweep the Academy Awards by winning Best Picture, Best Director, Best Actor, Best Actress, and Best Writing/Adaptation, a feat that remains rare in Oscar history. However, the more substantial impact of It Happened One Night is evident in its legacy. Well into the early twenty-first century, mainstream cinema continues to reproduce this film’s formula of the unlikely couple who “meet cute” and bicker their way into happily ever after. It Happened One Night is considered the template for the romantic-comedy film and screwball comedy and is also an early “road” film, structured around the bus/car/hitchhiking journey of spoiled heiress Ellie Andrews (Claudette Colbert) and unemployed reporter Peter Warne (Clark Gable). Together they evade the authorities so Ellie can get from Florida to New York and consummate her ill-conceived marriage to a well-heeled playboy. The sexual tension between Ellie and Peter plays out as class conflict, resolved at the film’s conclusion when Ellie runs away from the altar at her high-society wedding, returns to Peter, and honeymoons with him at a humble motel cottage resembling the ones they used—illegitimately but chastely—during their journey. Ellie’s wealthy father, at first an antagonist, becomes the patriarch with the heart of gold who enables Ellie and Peter to unite. Because the 1930 Hays Code was in force while the film was being shot, its sexual innuendoes were primarily conveyed through the witty conversation. Screenwriter Robert Riskin adapted the script from “Night Bus,” a short story by Samuel Hopkins Adams that first appeared in Cosmopolitan magazine in 1933 and got the notice of Capra, who was the leading director at Columbia Pictures at the time. It Happened One Night was the first of several Capra films that secured his reputation as an auteur and as a “populist” Depression-era director. A huge moneymaker for Columbia, the film was rebooked in theaters continuously for nearly a year. It Happened One Night also dramatically enhanced the careers of Gable and Colbert, whose star value increased considerably following their roles as the original screwball couple.
Novel Mutation in Cytochrome B of Plasmodium falciparum in One of Two Atovaquone-Proguanil Treatment Failures in Travelers Returning From Same Site in Nigeria
Authors: Plucinski Mateusz M. , Huber Curtis S. , Akinyi Sheila , Dalton Willard , Eschete Mary , Grady Katharine , Silva-Flannery Luciana , Mathison Blaine A. , Udhayakumar Venkatachalam , Arguin Paul M. , Barnwell John W. 
Published: July 2014

Abstract
Background.  Atovaquone-proguanil (AP) is the most commonly used treatment for uncomplicated Plasmodium falciparum malaria in the United States. Apparent AP treatment failures were reported 7 months apart in 2 American travelers who stayed in the same compound for foreign workers in Rivers State, Nigeria.
Methods.  We analyzed pretreatment (day 0) and day of failure samples from both travelers for mutations in the P falciparum cytochrome B (pfcytb) and dihydrofolate reductase (pfdhfr) genes associated with resistance to atovaquone and cycloguanil, the active metabolite of proguanil, respectively. We genotyped the parasites and sequenced their mitochondrial genomes.
Results.  On day 0, both travelers had proguanil-resistant genotypes but atovaquone-sensitive cytb sequences. Day of failure samples exhibited mutations in cytb for both travelers. One traveler had the common Y268S mutation, whereas the other traveler had a previously unreported mutation, I258M. The travelers had unrelated parasite genotypes and different mitochondrial genomes.
Conclusions.  Despite the infections likely having been contracted in the same site, there is no evidence that the cases were related. The mutations likely arose independently during the acute infection or treatment. Our results highlight the importance of genotyping parasites and sequencing the full cytb and dhfr genes in AP failures to rule out transmission of AP-resistant strains and identify novel mechanisms of AP resistance.
On the initial value problem for the wave equation in Friedmann–Robertson–Walker space–times
Authors: Abbasi Bilal , Craig Walter 
Published: July 2014

The propagatorW(t0,t1)(g,h) for the wave equation in a given space–time takes initial data (g(x),h(x)) on a Cauchy surface {(t,x) : t=t0} and evaluates the solution (u(t1,x),∂tu(t1,x)) at other timest1. The Friedmann–Robertson–Walker space–times are defined fort0,t1>0, whereas fort0→0, there is a metric singularity. There is a spherical means representation for the general solution of the wave equation with the Friedmann–Robertson–Walker background metric in the three spatial dimensional cases of curvatureK=0 andK=−1 given by S. Klainerman and P. Sarnak. We derive from the expression of their representation three results about the wave propagator for the Cauchy problem in these space–times. First, we give an elementary proof of the sharp rate of time decay of solutions with compactly supported data. Second, we observe that the sharp Huygens principle is not satisfied by solutions, unlike in the case of three-dimensional Minkowski space–time (the usual Huygens principle of finite propagation speed is satisfied, of course). Third, we show that for 0<t0<tthe limit,limt0→0+W(t0,t)(g,h)=W(0,t)(g)exists, it is independent ofh(x), and for all reasonable initial datag(x), it gives rise to a well-defined solution for allt>0 emanating from the space–time singularity att=0. Under reflectiont→−t, the Friedmann–Robertson–Walker metric gives a space–time metric fort<0 with a singular future att=0, and the same solution formulae hold. We thus have constructed solutionsu(t,x) of the wave equation in Friedmann–Robertson–Walker space–times which exist for all−∞<t<0and0<t<+∞, where in conformally regularized coordinates, these solutions are continuous through the singularityt=0 of space–time, taking on specified datau(0,⋅)=g(⋅) at the singular time.
Phylogeny, speciation, and distribution of the Japanese dwarf bamboos of genus Sasa and allies
Authors: Kobayashi Mikio 
Published: July 2014

AbstractDevelopment of the concept of the subfamily Bambusoideae during the past three decades is briefly reviewed. Phylogeny, putative hybrid taxa, a new, simplified key to explicit identification, and the revision of the distribution range among the Japanese dwarf bamboos of genus Sasa and its close allies are discussed. Based on analyses of the random amplified polymorphic DNA and morphological data and of FLOWERING LOCUS T (FT) homologs, parsimonious trees resolved that genus Sasa sec. Macrochlamys were the most basal and sect. Monilicladae were the next most basal, followed by the terminal sister clades of sects. Sasa and Crassinodi.
Neuropsychological follow‐up at school age of children with asymmetric ventricles or unilateral ventriculomegaly identified in utero
Authors: Atad‐Rapoport M , Schweiger A , Lev D , Sadan‐Strul S , Malinger G , Lerman‐Sagie T 
Published: July 2014

ObjectiveTo examine the long‐term neuropsychological outcome of children with a prenatal diagnosis of asymmetric ventricles or unilateral ventriculomegaly.DesignA clinic‐based neuropsychological study.SettingPaediatric neurology clinic.PopulationThirty‐three of 41 children, previously assessed at kindergarten age, with asymmetric ventricles or unilateral ventriculomegaly identified in utero, were recruited at school age for a neuropsychological follow‐up.MethodsAll children, 9–11 years of age, underwent a battery of neuropsychological tests and the parents completed behavioural rating questionnaires.Main outcome measuresResults of the neuropsychological assessment and parents' questionnaires.ResultsThere were no significant differences between children diagnosed with either asymmetric ventricles or unilateral ventriculomegaly in most parameters relative to the general population; the full‐scale IQ scores were 103.13 ± 12.43 and 103.56 ± 10.5, respectively. A significantly lower performance was found only on one measure of attention among the unilateral ventriculomegaly group and on writing speed tasks among the asymmetric ventricles group. Both study groups showed significantly higher scores than expected in the normal population on a verbal fluency test. Comparison of both groups combined with the normative population yielded significantly lower scores only in attention tests. Yet, the clinical population showed significantly higher scores on writing accuracy, processing speed and verbal fluency and lower rates of executive dysfunction.ConclusionsAsymmetric ventricles or unilateral ventriculomegaly identified in utero does not appear to affect long‐term mental development and school achievements. Further prospective research on a larger sample is needed in order to confirm our findings.
The effects of the Yuan‐dollar exchange rate on agricultural commodity trade between the United States, China, and their competitors
Authors: Devadoss Stephen , Hilland Amy , Mittelhammer Ron , Foltz John 
Published: July 2014

AbstractThe United States claims that the undervaluation of Chinese currency, the Yuan, causes U.S. exports to China to decrease and imports from China to increase. Furthermore, because the Yuan is undervalued only against the dollar, U.S. competitors have an advantage in exporting to China and China has an advantage over its competitors in exporting to the United States. This study develops a theoretical model to analyze the effect of the Yuan undervaluation on prices, supply, demand, and trade in the United States, China, and their competitors. This study applies a cointegration/error‐correction model to empirically quantify the short‐run and long‐run effects of the devaluation of the Yuan on important agricultural commodities traded between the United States, China, and their competitors. These commodities include Chinese imports of milk, soybeans, and cotton from the United States and U.S. imports of beans, fruit juice, and fruit from China. The results show that Yuan devaluation causes Chinese imports of U.S. milk, soybeans, and cotton to decline and U.S. imports of beans, fruit juice, and fruit from China to increase in the short run and in the long run.
AutoStyle: Automatic Style Transfer from Image Collections to Users' Images
Authors: Liu Yiming , Cohen Michael , Uyttendaele Matt , Rusinkiewicz Szymon 
Published: July 2014

AbstractStylizing photos, to give them an antique or artistic look, has become popular in recent years. The available stylization filters, however, are usually created manually by artists, resulting in a narrow set of choices. Moreover, it can be difficult for the user to select a desired filter, since the filters’ names often do not convey their functions. We investigate an approach to photo filtering in which the user provides one or more keywords, and the desired style is defined by the set of images returned by searching the web for those keywords. Our method clusters the returned images, allows the user to select a cluster, then stylizes the user's photos by transferring vignetting, color, and local contrast from that cluster. This approach vastly expands the range of available styles, and gives each filter a meaningful name by default. We demonstrate that our method is able to robustly transfer a wide range of styles from image collections to users’ photos.