bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of Tympanic Temperature Measurement in Firefighters Completing a Simulated Structural Firefighting Task
Authors: Keene Toby , Brearley Matt , Bowen Beth , Walker Anthony 
Published: September 2015

AbstractIntroductionIn the course of their duties, firefighters risk heat stroke and other medical conditions due to exertion in high-temperature environments. Infrared tympanic temperature measurement (TTym)is often used by Emergency Medical Services (EMS) to assess the core body temperature of firefighters. The accuracy of TTymin this setting has been called into question.Hypothesis/ProblemThis study aimed to examine the accuracy of TTymfor core body temperature assessment at emergency firefighting events compared with gastrointestinal temperature measurement (TGI) as measured by ingestible thermometers.MethodsForty-five (42 male, three female) professional urban firefighters from an Australian fire service completed two 20-minute work periods in a 100°C (± 5°C) heat chamber while wearing personal protective clothing (PPC) and breathing apparatus (weighing approximately 22 kg). Measurements were taken immediately before entering, and on exiting, the heat chamber. Tympanic temperature was assessed by an infrared tympanic thermometer and TGIwas measured by ingestible sensor and radio receiver.ResultsComplete data were available for 37 participants. Participant temperatures were higher on exiting the heat chamber than at baseline (TTym: 35.9°C (SD=0.7) vs 37.5°C (SD=0.8); TGI:37.2°C (SD=0.4) vs 38.6°C (SD=0.5)). Tympanic temperature underestimated TGIon average by 1.3°C (SD=0.5) before entering the chamber and by 1.0°C (SD=0.8) following the exercise. Using pooled data, the average underestimation was 1.2°C (SD=0.7).ConclusionTympanic thermometers cause an unreliable measure of core body temperature for firefighters engaged in fire suppression activities. Accurate and practical measures of core body temperature are required urgently.KeeneT,BrearleyM,BowenB,WalkerA.Accuracy of tympanic temperature measurement in firefighters completing a simulated structural firefighting task.Prehosp Disaster Med.2015;30(5):461–465.
The colonial origins of deforestation: an institutional analysis
Authors: Marchand Sébastien 
Published: September 2015

ABSTRACTThis paper investigates whether inherited colonial legacies influence deforestation rates in 60 former colonized developing countries. It is hypothesized that differences in deforestation among countries can be attributed to their colonial legacies shaping the current impact of the institutional background on deforestation. Overall, the author finds that institutions defined as the extent of democracy, the quality of property rights and the quality of government functioning (e.g., corruption), have a differential impact on deforestation rates according to colonial legacies as defined by the identity of the colonizer. More precisely, it is found that: (1) in countries characterized by ‘bad’ governance, former French colonies deforest relatively less than former British and Spanish colonies; whereas (2) in countries characterized by ‘good’ governance, the result is reversed. These results are robust when geography features are controlled for since the process of colonization was not random and depended on initial geographic and climatic conditions.
Improved answer-set programming encodings for abstract argumentation
Authors: GAGGL SARAH A. , MANTHEY NORBERT , RONCA ALESSANDRO , WALLNER JOHANNES P. , WOLTRAN STEFAN 
Published: September 2015

AbstractThe design of efficient solutions for abstract argumentation problems is a crucial step towards advanced argumentation systems. One of the most prominent approaches in the literature is to use Answer-Set Programming (ASP) for this endeavor. In this paper, we present new encodings for three prominent argumentation semantics using the concept of conditional literals in disjunctions as provided by the ASP-system clingo. Our new encodings are not only more succinct than previous versions, but also outperform them on standard benchmarks.
Concolic testing in logic programming
Authors: MESNARD FRED , PAYET ÉTIENNE , VIDAL GERMÁN 
Published: September 2015

AbstractSoftware testing is one of the most popular validation techniques in the software industry. Surprisingly, we can only find a few approaches to testing in the context of logic programming. In this paper, we introduce a systematic approach for dynamic testing that combines both concrete and symbolic execution. Our approach is fully automatic and guarantees full path coverage when it terminates. We prove some basic properties of our technique and illustrate its practical usefulness through a prototype implementation.
Practical run-time checking via unobtrusive property caching
Authors: STULOVA NATALIIA , MORALES JOSÉ F. , HERMENEGILDO MANUEL V. 
Published: September 2015

AbstractThe use of annotations, referred to as assertions or contracts, to describe program properties for which run-time tests are to be generated, has become frequent in dynamic programing languages. However, the frameworks proposed to support such run-time testing generally incur high time and/or space overheads over standard program execution. We present an approach for reducing this overhead that is based on the use of memoization to cache intermediate results of check evaluation, avoiding repeated checking of previously verified properties. Compared to approaches that reduce checking frequency, our proposal has the advantage of being exhaustive (i.e., all tests are checked at all points) while still being much more efficient than standard run-time checking. Compared to the limited previous work on memoization, it performs the task without requiring modifications to data structure representation or checking code. While the approach is general and system-independent, we present it for concreteness in the context of the Ciao run-time checking framework, which allows us to provide an operational semantics with checks and caching. We also report on a prototype implementation and provide some experimental results that support that using a relatively small cache leads to significant decreases in run-time checking overhead.
The Psychometric Properties of a Brief Version of the Systemizing Quotient
Authors: Veale Jaimie F. , Williams Matt N. 
Published: September 2015

Abstract. The construct of systemizing – the drive to construct or understand systems – has an important role in the Extreme Male Brain theory of autism. While a brief version of the Systemizing Quotient (SQ) has been proposed, there is a need to assess its psychometric properties. This study assessed factorial and construct validity of an 8-item version of the SQ on a sample of 627 participants. A single-factor latent variable model with a single correlated error term showed adequate fit in a confirmatory factor analysis. This model also demonstrated metric invariance across genders when controlling for an effect of age on item responses. Reliability was acceptable, α = .72. As further evidence for construct validity, SQ scores showed expected relationships with mental rotation performance, trait anxiety, childhood extroversion, childhood agreeableness, and gender. Overall, the results indicated good psychometric properties for the brief version of the SQ, suggesting that this scale could be useful when researchers require a systemizing measure that is minimally burdensome to complete.
Balancing functions of annexin A6 maintain equilibrium between hypertrophy and apoptosis in cardiomyocytes
Authors: Banerjee P , Chander V , Bandyopadhyay A 
Published: September 2015

AbstractPathological cardiac hypertrophy is a major risk factor associated with heart failure, a state concomitant with increased cell death. However, the mechanism governing progression of hypertrophy to apoptosis at the single-cell level remains elusive. Here, we demonstrate annexin A6 (Anxa6), a calcium (Ca2+)-dependent phospholipid-binding protein critically regulates the transition of chronic hypertrophied cardiomyocytes to apoptosis. Treatment of the H9c2(2-1) cardiomyocytes with hypertrophic agonists upregulates and relocalizes Anxa6 with increased cytosolic punctate appearance. Live cell imaging revealed that chronic exposure to hypertrophic agonists such as phenylephrine (PE) compromises the mitochondrial membrane potential (ΔΨm) and morphological dynamics. Such chronic hypertrophic induction also activated the caspases 9 and 3 and induced cleavage of the poly-(ADP-ribose) polymerase 1 (Parp1), which are the typical downstream events in the mitochondrial pathways of apoptosis. An increased rate of apoptosis was evident in the hypertrophied cardiomyocytes after 48–72 h of treatment with the hypertrophic agonists. Anxa6 was progressively associated with the mitochondrial fraction under chronic hypertrophic stimulation, and Anxa6 knockdown severely abrogated mitochondrial network and dynamics. Ectopically expressed Anxa6 protected the mitochondrial morphology and dynamics under PE treatment, and also increased the cellular susceptibility to apoptosis. Biochemical analysis showed that Anxa6 interacts with Parp1 and its 89 kDa cleaved product in a Ca2+-dependent manner through the N-terminal residues (1–28). Furthermore, expression of Anxa6S13E, a mutant dominant negative with respect to Parp1 binding, served as an enhancer of mitochondrial dynamics, even under chronic PE treatment. Chemical inhibition of Parp1 activity released the cellular vulnerability to apoptosis in Anxa6-expressing stable cell lines, thereby shifting the equilibrium away from cell death. Taken together, the present study depicts a dual regulatory function of Anxa6 that is crucial for balancing hypertrophy with apoptosis in cardiomyocytes.
mTORC2 controls cancer cell survival by modulating gluconeogenesis
Authors: Khan MW , Biswas D , Ghosh M , Mandloi S , Chakrabarti S , Chakrabarti P 
Published: September 2015

AbstractFor rapid tumor growth, cancer cells often reprogram the cellular metabolic processes to obtain enhanced anabolic precursors and energy. The molecular changes of such metabolic rewiring are far from established. Here we explored the role of mTOR (mechanistic target of rapamycin), which serves as a key regulator of cell growth, proliferation and survival, in the metabolic reprograming of cancer cells. When we inhibited mTOR in human hepatocellular carcinoma (HCC) and renal cell carcinoma (RCC) cells, using pharmacologic inhibitors or by RNA interference, we noticed shuttle of the glycolytic flux to gluconeogenesis pathway along with reduction in cellular proliferation and survival. Augmentation of gluconeogenesis was mechanistically linked to upregulation of the key gluconeogenic enzymes PCK1 and G6PC expressions, enhanced lactate dehydrogenase activity and glucose-derived lipogenesis without causing any attenuation in mitochondrial function. Interestingly, concomitant knocking down of PCK1 and not G6PC along with mTOR pathway could overcome the inhibition of cancer cell proliferation and survival. These observations were validated by identifying distinctive diminution of PCK1 and G6PC expressions in human HCC and RCC transcriptome data. Significant correlation between mTOR-dependent upregulation of PCK1 and cell death in different cancer cell lines further emphasizes the physiological relevance of this pathway. We reveal for the first time that inhibition of mTORC2 and consequent redistribution of glycolytic flux can have a prosurvival role in HCC and RCC cancer cells only in the presence of downregulation of gluconeogenesis pathway genes, thus identifying novel pivots of cancer cell metabolic rewiring and targets for therapy.
Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2
Authors: Gurgis FMS , Åkerfeldt MC , Heng B , Wong C , Adams S , Guillemin GJ , Johns TG , Chircop M , Munoz L 
Published: September 2015

AbstractMAPK-activated protein kinase 2 (MK2) is a checkpoint kinase involved in the DNA damage response. MK2 inhibition enhances the efficacy of chemotherapeutic agents; however, whether MK2 inhibition alone, without concurrent chemotherapy, would attenuate survival of cancer cells has not been investigated. CMPD1 is a widely used non-ATP competitive inhibitor that prevents MK2 phosphorylation. We employed CMPD1 together with MK2 knock-down and ATP-competitive MK2 inhibitor III (MK2i) in a panel of glioblastoma cells to assess whether MK2 inhibition could induce cancer cell death. While CMPD1 was effective at selective killing of cancer cells, MK2i and MK2 knock-down had no effect on viability of glioblastoma cells. CMPD1 treatment induced a significant G2/M arrest but MK2i-treated cells were only minimally arrested at G1 phase. Intriguingly, at doses that were cytotoxic to glioblastoma cells, CMPD1 did not inhibit phosphorylation of MK2 and of its downstream substrate Hsp27. These results suggest that CMPD1 exhibits cytotoxic activity independently of MK2 inhibition. Indeed, we identified tubulin as a primary target of the CMPD1 cytotoxic activity. This study demonstrates how functional and mechanistic studies with appropriate selection of test compounds, combining genetic knock-down and pharmacological inhibition, coordinating timing and dose levels enabled us to uncover the primary target of an MK2 inhibitor commonly used in the research community. Tubulin is emerging as one of the most common non-kinase targets for kinase inhibitors and we propose that potential tubulin-targeting activity should be assessed in preclinical pharmacology studies of all novel kinase inhibitors.
Predator strike shapes antipredator phenotype through new genetic interactions in water striders
Authors: Armisén David , Nagui Refki Peter , Crumière Antonin Jean Johan , Viala Séverine , Toubiana William , Khila Abderrahman 
Published: September 2015

AbstractHow novel genetic interactions evolve, under what selective pressures, and how they shape adaptive traits is often unknown. Here we uncover behavioural and developmental genetic mechanisms that enable water striders to survive attacks by bottom-striking predators. Long midlegs, critical for antipredator strategy, are shaped through a lineage-specific interaction between the Hox protein Ultrabithorax (Ubx) and a new target gene calledgilt. The differences in leg morphologies are established through modulation ofgiltdifferential expression between mid and hindlegs under Ubx control. Furthermore, short-legged water striders, generated throughgiltRNAi knockdown, exhibit reduced performance in predation tests. Therefore, the evolution of the new Ubx–giltinteraction contributes to shaping the legs that enable water striders to dodge predator strikes. These data show how divergent selection, associated with novel prey–predator interactions, can favour the evolution of new genetic interactions and drive adaptive evolution.
Novel approach for label free super-resolution imaging in far field
Authors: Alexandrov Sergey A. , McGrath James , Subhash Hrebesh , Boccafoschi Francesca , Giannini Cinzia , Leahy Martin 
Published: September 2015

AbstractProgress in the emerging areas of science and technology, such as bio- and nano-technologies, depends on development of corresponding techniques for imaging and probing the structures with high resolution. Recently, the far field diffraction resolution limit in the optical range has been circumvented and different methods of super-resolution optical microscopy have been developed. The importance of this breakthrough achievement has been recognized by Nobel Prize for Chemistry in 2014. However, the fluorescence based super-resolution techniques only function with fluorescent molecules (most of which are toxic and can destroy or lead to artificial results in living biological objects) and suffer from photobleaching. Here we show a new way to break the diffraction resolution limit, which is based on nano-sensitivity to internal structure. Instead of conventional image formation as 2D intensity distribution, in our approach images are formed as a result of comparison of the axial spatial frequency profiles, reconstructed for each image point. The proposed approach dramatically increases the lateral resolution even in presence of noise and allows objects to be imaged in their natural state, without any labels.
Silver Nanowire Transparent Conductive Electrodes for High-Efficiency III-Nitride Light-Emitting Diodes
Authors: Oh Munsik , Jin Won-Yong , Jun Jeong Hyeon , Jeong Mun Seok , Kang Jae-Wook , Kim Hyunsoo 
Published: September 2015

AbstractSilver nanowires (AgNWs) have been successfully demonstrated to function as next-generation transparent conductive electrodes (TCEs) in organic semiconductor devices owing to their figures of merit, including high optical transmittance, low sheet resistance, flexibility and low-cost processing. In this article, high-quality, solution-processed AgNWs with an excellent optical transmittance of 96.5% at 450 nm and a low sheet resistance of 11.7 Ω/sq were demonstrated as TCEs in inorganic III-nitride LEDs. The transmission line model applied to the AgNW contact to p-GaN showed that near ohmic contact with a specific contact resistance of ~10−3 Ωcm2 was obtained. The contact resistance had a strong bias-voltage (or current-density) dependence: namely, field-enhanced ohmic contact. LEDs fabricated with AgNW electrodes exhibited a 56% reduction in series resistance, 56.5% brighter output power, a 67.5% reduction in efficiency droop and a approximately 30% longer current spreading length compared to LEDs fabricated with reference TCEs. In addition to the cost reduction, the observed improvements in device performance suggest that the AgNWs are promising for application as next-generation TCEs, to realise brighter, larger-area, cost-competitive inorganic III-nitride light emitters.
Light intensity modulation by coccoliths of Emiliania huxleyi as a micro-photo-regulator
Authors: Mizukawa Yuri , Miyashita Yuito , Satoh Manami , Shiraiwa Yoshihiro , Iwasaka Masakazu 
Published: September 2015

AbstractIn this study, we present experimental evidence showing that coccoliths have light-scattering anisotropy that contributes to a possible control of solar light exposure in the ocean. Changing the angle between the incident light and an applied magnetic field causes differences in the light-scattering intensities of a suspension of coccoliths isolated from Emiliania huxleyi. The magnetic field effect is induced by the diamagnetic torque force directing the coccolith radial plane perpendicular to the applied magnetic fields at 400 to 500 mT. The developed technique reveals the light-scattering anisotropies in the 3-μm-diameter floating coccoliths by orienting themselves in response to the magnetic fields. The detached coccolith scatters radially the light incident to its radial plane. The experimental results on magnetically oriented coccoliths show that an individual coccolith has a specific direction of light scattering, although the possible physiological effect of the coccolith remains for further study, focusing on the light-scattering anisotropies of coccoliths on living cells.
Layered Seed-Growth of AgGe Football-like Microspheres via Precursor-Free Picosecond Laser Synthesis in Water
Authors: Zhang Dongshi , Gökce Bilal , Notthoff Christian , Barcikowski Stephan 
Published: September 2015

AbstractHybrid particles are of great significance in terms of their adjustable optical, electronic, magnetic, thermal and mechanical properties. As a novel technique, laser ablation in liquids (LAL) is famous for its precursor-free, “clean” synthesis of hybrid particles with various materials. Till now, almost all the LAL-generated particles originate from the nucleation-growth mechanism. Seed-growth of particles similar to chemical methods seems difficult to be achieved by LAL. Here, we not only present novel patch-joint football-like AgGe microspheres with a diameter in the range of 1 ~ 7 μm achievable by laser ablation in distilled water but also find direct evidences of their layered seed growth mechanism. Many critical factors contribute to the formation of AgGe microspheres: fast laser-generated plasma process provide an excellent condition for generating large amount of Ge and Ag ions/atoms, their initial nucleation and galvanic replacement reaction, while cavitation bubble confinement plays an important role for the increase of AgGe nuclei and subsequent layered growth in water after bubble collapse. Driven by work function difference, Ge acts as nucleation agent for silver during alloy formation. This new seed-growth mechanism for LAL technique opens new opportunities to develop a large variety of novel hybrid materials with controllable properties.
Hidden biodiversity in an ancient lake: phylogenetic congruence between Lake Tanganyika tropheine cichlids and their monogenean flatworm parasites
Authors: Vanhove Maarten P. M. , Pariselle Antoine , Van Steenberge Maarten , Raeymaekers Joost A. M. , Hablützel Pascal I. , Gillardin Céline , Hellemans Bart , Breman Floris C. , Koblmüller Stephan , Sturmbauer Christian , Snoeks Jos , Volckaert Filip A. M. , Huyse Tine 
Published: September 2015

AbstractThe stunning diversity of cichlid fishes has greatly enhanced our understanding of speciation and radiation. Little is known about the evolution of cichlid parasites. Parasites are abundant components of biodiversity, whose diversity typically exceeds that of their hosts. In the first comprehensive phylogenetic parasitological analysis of a vertebrate radiation, we study monogenean parasites infecting tropheine cichlids from Lake Tanganyika. Monogeneans are flatworms usually infecting the body surface and gills of fishes. In contrast to many other parasites, they depend only on a single host species to complete their lifecycle. Our spatially comprehensive combined nuclear-mitochondrial DNA dataset of the parasites covering almost all tropheine host species (N = 18), reveals species-rich parasite assemblages and shows consistent host-specificity. Statistical comparisons of host and parasite phylogenies based on distance and topology-based tests demonstrate significant congruence and suggest that host-switching is rare. Molecular rate evaluation indicates that species ofCichlidogyrusprobably diverged synchronically with the initial radiation of the tropheines. They further diversified through within-host speciation into an overlooked species radiation. The unique life history and specialisation of certain parasite groups has profound evolutionary consequences. Hence, evolutionary parasitology adds a new dimension to the study of biodiversity hotspots like Lake Tanganyika.
Self-assembled large scale metal alloy grid patterns as flexible transparent conductive layers
Authors: Mohl Melinda , Dombovari Aron , Vajtai Robert , Ajayan Pulickel M. , Kordas Krisztian 
Published: September 2015

AbstractThe development of scalable synthesis techniques for optically transparent, electrically conductive coatings is in great demand due to the constantly increasing market price and limited resources of indium for indium tin oxide (ITO) materials currently applied in most of the optoelectronic devices. This work pioneers the scalable synthesis of transparent conductive films (TCFs) by exploiting the coffee-ring effect deposition coupled with reactive inkjet printing and subsequent chemical copper plating. Here we report two different promising alternatives to replace ITO, palladium-copper (PdCu) grid patterns and silver-copper (AgCu) fish scale like structures printed on flexible poly(ethylene terephthalate) (PET) substrates, achieving sheet resistance values as low as 8.1 and 4.9 Ω/sq, with corresponding optical transmittance of 79% and 65% at 500 nm, respectively. Both films show excellent adhesion and also preserve their structural integrity and good contact with the substrate for severe bending showing less than 4% decrease of conductivity even after 105 cycles. Transparent conductive films for capacitive touch screens and pixels of microscopic resistive electrodes are demonstrated.