bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolomics for undergraduates: Identification and pathway assignment of mitochondrial metabolites
Authors: Marques Ana Patrícia , Serralheiro Maria Luisa , Ferreira António E.N. , Freire Ana Ponces , Cordeiro Carlos , Silva Marta Sousa 
Published: November 2015

AbstractMetabolomics is a key discipline in systems biology, together with genomics, transcriptomics, and proteomics. In this omics cascade, the metabolome represents the biochemical products that arise from cellular processes and is often regarded as the final response of a biological system to environmental or genetic changes. The overall screening approach to identify all the metabolites in a given biological system is called metabolic fingerprinting. Using high‐resolution and high‐mass accuracy mass spectrometry, large metabolome coverage, sensitivity, and specificity can be attained. Although the theoretical concepts of this methodology are usually provided in life‐science programs, hands‐on laboratory experiments are not usually accessible to undergraduate students. Even if the instruments are available, there are not simple laboratory protocols created specifically for teaching metabolomics. We designed a straightforward hands‐on laboratory experiment to introduce students to this methodology, relating it to biochemical knowledge through metabolic pathway mapping of the identified metabolites. This study focuses on mitochondrial metabolomics since mitochondria have a well‐known, medium‐sized cellular sub‐metabolome. These features facilitate both data processing and pathway mapping. In this experiment, students isolate mitochondria from potatoes, extract the metabolites, and analyze them by high‐resolution mass spectrometry (using an FT‐ICR mass spectrometer). The resulting mass list is submitted to an online program for metabolite identification, and compounds associated with mitochondrial pathways can be highlighted in a metabolic network map. © 2015 by The International Union of Biochemistry and Molecular Biology, 44:38–54, 2016.
Catalytic Depolymerization of Chitin with Retention of N‐Acetyl Group
Authors: Yabushita Mizuho , Kobayashi Hirokazu , Kuroki Kyoichi , Ito Shogo , Fukuoka Atsushi 
Published: November 2015

AbstractChitin, a polymer of N‐acetylglucosamine units with β‐1,4‐glycosidic linkages, is the most abundant marine biomass. Chitin monomers containing N‐acetyl groups are useful precursors to various fine chemicals and medicines. However, the selective conversion of robust chitin to N‐acetylated monomers currently requires a large excess of acid or a long reaction time, which limits its application. We demonstrate a fast catalytic transformation of chitin to monomers with retention of N‐acetyl groups by combining mechanochemistry and homogeneous catalysis. Mechanical‐force‐assisted depolymerization of chitin with a catalytic amount of H2SO4 gave soluble short‐chain oligomers. Subsequent hydrolysis of the ball‐milled sample provided N‐acetylglucosamine in 53 % yield, and methanolysis afforded 1‐O‐methyl‐N‐acetylglucosamine in yields of up to 70 %. Our process can greatly reduce the use of acid compared to the conventional process.
Multi‐interface cognitive radio for enhanced routing in multi‐hop cellular networks
Authors: Thomas Ginu , Seet Boon‐Chong 
Published: November 2015

SummaryMulti‐hop cellular network (MCN) is a wireless communication architecture that combines the benefits of conventional single‐hop cellular networks and multi‐hop ad hoc relaying networks. The route selection in MCN depends on the availability of intermediate nodes and their neighborhood connectivity. Cognitive radio (CR) is an emerging communication paradigm that exploits the available radio frequencies opportunistically for the effective utilization of the radio frequency spectrum. The incorporation of CR and mobile ad hoc network routing protocols in MCN could potentially improve the spectrum utilization and the routing performance of MCN. This paper firstly presents the proposed model for the multi‐interface CR mobile node with transceiver synchronization and then investigates its opportunistic spectrum utilization and routing performance in MCN. Copyright © 2015 John Wiley & Sons, Ltd.
Conjugate margin pattern of the Southwest Sub‐basin, South China Sea: insights from deformation structures in the continent‐ocean transition zone
Authors: Ding Weiwei , Li Jiabiao 
Published: November 2015

AbstractEight cross‐sections from the continent‐ocean transition zone of the Southwest Sub‐basin, South China Sea, have been used to compare conjugate rifted margins that are typical of magma‐poor rift systems. The geological timing of the break‐up unconformity in the continental margins shows that the Reed Bank and the Dangerous Grounds in the south continental margin connect with the Zhongsha Islands and the western Phu Khanh Basin, which experienced northwest‐southeast oriented movement after the opening of the Southwest Sub‐basin. Detailed interpretations identify a range of deformational and sedimentary features in the continent‐ocean transition zones with and without rigid blocks. Remarkable structural similarities appear in the transition zone lying within the convex‐shaped area shaped by rigid blocks of the conjugate margin (e.g. the Zhongsha Islands and the Reed Bank) or within concave‐shaped areas sandwiched by rigid blocks. Rigid tectonic blocks such as the Zhongsha Islands and the Reed Bank played important roles in both the shaping of the continent‐ocean boundary and the initial continental break‐up. Copyright © 2015 John Wiley & Sons, Ltd.
The “silent” imprint of musical training
Authors: Klein Carina , Liem Franziskus , Hänggi Jürgen , Elmer Stefan , Jäncke Lutz 
Published: November 2015

AbstractPlaying a musical instrument at a professional level is a complex multimodal task requiring information integration between different brain regions supporting auditory, somatosensory, motor, and cognitive functions. These kinds of task‐specific activations are known to have a profound influence on both the functional and structural architecture of the human brain. However, until now, it is widely unknown whether this specific imprint of musical practice can still be detected during rest when no musical instrument is used. Therefore, we applied high‐density electroencephalography and evaluated whole‐brain functional connectivity as well as small‐world topologies (i.e., node degree) during resting state in a sample of 15 professional musicians and 15 nonmusicians. As expected, musicians demonstrate increased intra‐ and interhemispheric functional connectivity between those brain regions that are typically involved in music perception and production, such as the auditory, the sensorimotor, and prefrontal cortex as well as Broca's area. In addition, mean connectivity within this specific network was positively related to musical skill and the total number of training hours. Thus, we conclude that musical training distinctively shapes intrinsic functional network characteristics in such a manner that its signature can still be detected during a task‐free condition. Hum Brain Mapp 37:536–546, 2016. © 2015 Wiley Periodicals, Inc.
Viele Quellen anzapfen
Authors: Dworschak Dominik , Tesch Silke , Böhme Uwe 
Published: November 2015

AbstractDass eine Suche mit Google für eine wissenschaftliche Literaturrecherche nicht genügt, hat sich inzwischen herumgesprochen. Aber es reicht häufig nicht, in nur einer Datenbank zu suchen — so gut sie auch sein mag.
Social Return on Investment Analysis
Authors: Walk Marlene , Greenspan Itay , Crossley Honey , Handy Femida 
Published: November 2015

AbstractThis article uses a social return on investment (SROI) methodology to analyze the social impact of a social enterprise offering a job and skills training program to an unemployed, largely female population. The social enterprise is based in Toronto (Canada) and run by a nonprofit agency dedicated to the advancement and empowerment of women, primarily immigrants, through access to employment. We focus our analysis on a job and skills training program that provides clients with the skills and tools that they need to successfully seek employment in their efforts to (re‐)enter the Canadian labor market. Our goal is to determine the tangible and intangible program outcomes by applying and testing the SROI methodology.
Sensitivity analyses for partially observed recurrent event data
Authors: Akacha Mouna , Ogundimu Emmanuel O. 
Published: November 2015

Recurrent events involve the occurrences of the same type of event repeatedly over time and are commonly encountered in longitudinal studies. Examples include seizures in epileptic studies or occurrence of cancer tumors. In such studies, interest lies in the number of events that occur over a fixed period of time. One considerable challenge in analyzing such data arises when a large proportion of patients discontinues before the end of the study, for example, because of adverse events, leading to partially observed data. In this situation, data are often modeled using a negative binomial distribution with time‐in‐study as offset. Such an analysis assumes that data are missing at random (MAR). As we cannot test the adequacy of MAR, sensitivity analyses that assess the robustness of conclusions across a range of different assumptions need to be performed.Sophisticated sensitivity analyses for continuous data are being frequently performed. However, this is less the case for recurrent event or count data. We will present a flexible approach to perform clinically interpretable sensitivity analyses for recurrent event data. Our approach fits into the framework of reference‐based imputations, where information from reference arms can be borrowed to impute post‐discontinuation data. Different assumptions about the future behavior of dropouts dependent on reasons for dropout and received treatment can be made. The imputation model is based on a flexible model that allows for time‐varying baseline intensities. We assess the performance in a simulation study and provide an illustration with a clinical trial in patients who suffer from bladder cancer. Copyright © 2015 John Wiley & Sons, Ltd.
The effects of cavity‐filling techniques on microleakage in class II resin restorations prepared with Er:YAG laser and diamond bur: A scanning electron microscopy study
Authors: Ozel Emre , Tuna Elif Bahar , Firatli Erhan 
Published: November 2015

SummaryThe purpose of this study was to investigate how two cavity‐filling techniques affect microleakage in class II resin restorations prepared with Er:YAG laser and diamond bur. Standard MO and DO cavities were prepared in 20 extracted third molars, each randomly assigned to either Group‐1 [Herculite XRV Ultra‐bur‐prepared cavity(bp)], Group‐2 [Herculite XRV Ultra‐laser‐prepared cavity(lp)], Group‐3 (SonicFill‐(bp)], or Group‐4 [SonicFill‐(lp)]. For Groups 2 and 4, cavities were prepared by using an Er:YAG laser with a wavelength of 2.94 μm, output power of 200 mJ/pulse, and repetition rate of 20Hz. Teeth were restored with a one‐step, self‐etch adhesive material (OptiBond All‐in‐One), a nanohybrid composite (Herculite XRV Ultra), and a bulk‐fill composite (SonicFill) according to the manufacturer's instructions. Five teeth from each group were chosen for microleakage investigation and two teeth for scanning electron microscope evaluation. Statistical analysis was performed by using Kruskal–Wallis test. Pair‐wise comparisons were performed by Mann–Whitney U test with Bonferroni correction (p < 0.05). The statistical analysis of data revealed greater microleakage in cervical versus occlusal regions in all groups (P < 0.05). Group‐2 yielded a higher degree of marginal leakage than Group‐3 in terms of occlusal surfaces (p < 0.05). For cervical regions, a statistically significant difference was observed between Groups 2 and 3 as well as Groups 2 and 4 (p < 0.05). Group‐3 exhibited significantly better marginal sealing than Group‐1 in the cervical region (p < 0.05). The cavities prepared using an Er:YAG laser showed greater microleakage than those conventionally prepared using burs regardless of restorative material at both occlusal and cervical margins. SCANNING 38:389–395, 2016. © 2015 Wiley Periodicals, Inc.
Acute exposure to bisphenol A and cadmium causes changes in the morphology of gerbil ventral prostates and promotes alterations in androgen‐dependent proliferation and cell death
Authors: Colleta Simone J. , Antoniassi Julia Q. , Zanatelli Marianna , Santos Fernanda C.A. , Góes Rejane M. , Vilamaior Patricia S.L. , Taboga Sebastião R. 
Published: November 2015

ABSTRACTBisphenol A (BPA) and cadmium (Cd) are environmental pollutants that are implicated in potential reproductive effects, including damage to the prostate gland. Their action during puberty requires analysis to determine the relationship of these compounds with the testosterone peak that occurs during this phase. This study evaluated whether exposure to BPA and Cd during puberty can cause changes in the morphology, proliferation and cell death and androgen receptor (AR) immunostaining of the ventral prostates of normal and castrated male gerbils (Meriones unguiculatus), considering an acute exposure to the chemicals and evaluation after short (52d) and long (120d) periods. Generally, morphometric‐stereological results demonstrated that administration of BPA and Cd (individually or in combination) increased epithelial height, smooth muscle layer (SML) thickness and nuclear area and perimeter, and that these parameters were reduced in castrated animals. In addition, these groups showed important inflammatory processes but not prostate lesions. The proliferation/death rates of prostatic cells obtained by PCNA and TUNEL immunostaining demonstrated increased cell death in the 52d groups; in contrast, the gland acquired a more proliferative nature in the 120d groups. AR immunostaining showed that BPA and Cd compounds interact with ARs in different ways depending on the evaluated period and the hormonal profile of the animal. We conclude that BPA and cadmium are important agents in changing the morphology, proliferation and death of prostatic cells, in addition to interacting with ARs in different patterns. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 48–61, 2017.
The Characteristics of Bone Metastasis in Patients with Colorectal Cancer: A Long‐Term Report from a Single Institution
Authors: Baek Se‐Jin , Hur Hyuk , Min Byung‐Soh , Baik Seung‐Hyuk , Lee Kang‐Young , Kim Nam‐Kyu 
Published: November 2015

AbstractBackgroundBone metastasis in patients with colorectal cancer (CRC) is very rare, and data are extremely lacking. We aimed to evaluate the characteristics of bone metastasis in patients with CRC.
Materials and methodsWe performed a chart review of 63 patients (1.1 %) with bone metastasis among 5479 patients who underwent surgery for CRC.ResultsMost patients were stage 3 (17.5 %) or 4 (73.0 %), and 32 patients (50.8 %) were diagnosed with bone metastasis at initial diagnoses of CRC. Thirty‐one patients developed bone metastasis during the follow‐up period with median 10.1‐month interval. PET–CT was most frequently used for the diagnosis of bone metastasis (71.4 %), and the spine was the most commonly involved site (77.8 %). Most patients had multiple bone metastases (73.0 %) and other metastases (87.3 %). Bone pain was the most common skeletal‐related event (25.4 %), and patients were treated with radiation (25.4 %), surgery (14.3 %), or bisphosphonate (6.3 %). The median survival time was 17.8 months, and the 5‐year survival rate was 5.7 %. In the multivariate analysis, the risk factors for survival included initial bone metastasis (hazard ratio [HR] 3.03; P < 0.001) and bone metastasis from colon cancer (HR 1.87; P = 0.04).
ConclusionBone metastasis in patients with CRC is extremely rare and shows poor prognosis.
ISDN2014_0016: REMOVED: Reproducibility in science: How video journals increase research validity and productivity
Authors: Henderson Kira M. 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0018: REMOVED: The relationship between Chinese high school students' academic stress and depressive symptoms: The 5‐HTTLPR gene polymorphism as a moderator
Authors: Liu Yangyang 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0020: REMOVED: Glycoconjugates distribution during developing mouse Spinal Cord motor organizer
Authors: Fazel Alireza , Vojoudi Elham , Ebrahimi Vahid , Ebrahimzadeh Alireza 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0023: REMOVED: Mindfulness meditation with incarcerated youth: A randomized controlled trial informed by neuropsychosocial theories of adolescence
Authors: Evans‐Chase Michelle 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0024: REMOVED: Risk‐taking and self‐regulation: A systematic review of the analysis of delinquency outcomes in the juvenile justice intervention literature 1996–2009
Authors: Evans‐Chase Michelle , Kim Minseop , Zhou Huiquan 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0030: REMOVED: Age‐dependent regulation of GLT‐1/EAAT2 expression during traumatic brain injury: A coherent and mutual role for NF‐κB and N‐myc
Authors: Gupta R.K. , Prasad S. 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0046: REMOVED: Assessment of examination stress in young adults
Authors: Pranita A. , Kharche J.S. , Balsubramanian B. , Joshi A.R. 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0050: REMOVED: Apocyanin, a microglia PHOX inhibitor prevents dopaminergic degeneration in Lipopolysaccharide induced Parkinson's disease model
Authors: Sharma Neha , Nehru Bimla 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0052: REMOVED: The effects of melodic intonation therapy on MLU in 7–10‐year Persian non‐verbal autistic, male children
Authors: Ferdosi Neda , Ashayeri Hassan , Modarresi Yahya , Rovshan Belghis 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0063: REMOVED: Pathological sharp waves and hyperexcitability in a mouse model of Fetal Alcohol Spectrum Disorder (FASD)
Authors: Krawczyk Micahl , Ramani Meera , Mylvaganam Shanthini , Carlen Peter L. 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0071: REMOVED: Insulin protects SH‐SY5Y neuroblastoma cells against 6‐OHDA induced toxicity
Authors: Maryam Moosavi , Esmat Amiri , Rasoul Ghasemi , Asadollah Zarifkar 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0074: REMOVED: Effects of adenosine A2a receptor agonist and antagonist on hippocampal nuclear factor‐kB expression preceded by MDMA toxicity
Authors: Mehdizadeh Mehdi , Kermanian Fatemeh , Soleimani Mansooreh , Ebrahimzadeh Alireza , Haghir Hossein 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0106: REMOVED: Age‐of‐script‐acquisition effects in the default‐mode network
Authors: Gilead M. , Liberman N. , Maril A. 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.