bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of lipoprotein glomerulopathy with thrombotic microangiopathy due to malignant hypertension
Authors: Wu Yu , Chen Xiaohan , Yang Yuan , Wang Baohe , Liu Xiaoxia , Tao Ye , Fu Ping , Hu Zhangxue 
Published: March 2013

Abstract

Background
Lipoprotein glomerulopathy (LPG) is a rare inherited renal disease characterized by intraglomerular lipoprotein within the lumina of severely dilated glomerular capillaries. The common clinical presentation of LPG includes proteinuria or nephrotic syndrome. Hypertension and anemia were thought to be mild in LPG. Thrombotic microangiopathy (TMA) in LPG has not been previously reported. In this report, we present a patient with LPG that developed TMA. To the best of our knowledge, this is the first report of TMA in LPG.

Case presentation
Four years ago (2005), a 19-year-old Chinese woman was diagnosed with nephrotic syndrome and provided prednisone treatment. A combination of prednisone and cyclophosphamide did not have any effect and was discontinued after six months. Although she was steroid-resistant, over the next subsequent three years, she maintained normal renal function without anemia and thrombocytopenia. In February 2009, she had a severe headache and blurry vision and presented at a local hospital with severe hypertension. Blood pressure was 220/160 mmHg. Laboratory data showed hemoglobin 3.8 g/dL; platelet counts 29×109/L; urinary protein 7.90 g/d; total bilirubin 29.9 umol/L; indirect bilirubin 28.2 umol/L; LDH 1172 U/L; ALB 2.66 g/dL; urea nitrogen 52 mg/dL; serum creatinine 3.2 mg/dL; triglyceride 253 mg/dL; total cholesterol 273 mg/dL. ANA, ds-DNA, ANCA, anti-GBM antibody and anticardiolipin were all negative. A renal biopsy revealed LPG with TMA. Genetic evaluation showed the patient carried the APOE Kyoto mutation. Adequate control of blood pressure improved microangiopathic anemia and thrombocytopenia, however, renal function did not improve and she eventually developed uremia and became hemodialysis dependent.

Conclusion
We report on a rare case of TMA probably due to malignant hypertension in LPG. Early lipid-lowering and antihypertensive treatment may improve outcome. The pathophysiologic relationship between LPG and TMA should be investigated further.
Some existence and uniqueness theorems on ordered metric spaces via generalized distances
Authors: Rouzkard Fayyaz , Imdad Mohammad , Gopal Dhananjay 
Published: March 2013

Abstract
The purpose of this paper is to prove some fixed point theorems in a complete metric space equipped with a partial ordering using w-distances together with the aid of altering functions.

MSC:54H25, 47H10.
Comparison of prasugrel and clopidogrel reloading on high platelet reactivity in clopidogrel-loaded patients undergoing percutaneous coronary intervention (PRAISE-HPR): a study protocol for a prospective randomized controlled clinical trial
Authors: Lee Dong-Hyun , Kim Moo Hyun , Park Tae-Ho , Park Jong Sung , Park Kyungil , Zhang Hong-Zhe , Seo Jeong-Min , Lee Michael S 
Published: March 2013

Abstract

Background
Patients with reduced responsiveness to clopidogrel often have diminished platelet inhibition, a factor associated with increased rates of major adverse cardiovascular events. Clinical trials that have focused on reducing high on-treatment platelet reactivity (HPR) with an additional loading dose of clopidogrel have reported varying effects. Prasugrel, a newer thienopyridine, exhibits a more consistent antiplatelet effect and more rapid onset time when compared to clopidogrel. We hypothesize that prasugrel reloading would be more effective than clopidogrel reloading in patients with HPR after an initial loading dose of clopidogrel.

Method/Design
Comparison of Prasugrel and Clopidogrel Reloading on High Platelet Reactivity in Clopidogrel-loaded Patients Undergoing Percutaneous Coronary Intervention (PRAISE-HPR) is a prospective, randomized, open-label, active controlled study. A total of 76 patients undergoing percutaneous coronary intervention (PCI), with HPR after administration of a loading dose of clopidogrel will be randomly assigned to either prasugrel or clopidogrel groups, and patients in each group will be reloaded with 20 mg of prasugrel or 300 mg of clopidogrel. The primary endpoint will be HPR at 24 hours after PCI, as determined by the VerifyNow assay during the study period. The rate of sustained high platelet reactivity and 30-day clinical outcomes will also be measured.

Discussion
PRAISE-HPR is a randomized controlled clinical trial to investigate the efficacy and safety of reloading prasugrel and clopidogrel in suppressing residual high platelet reactivity. The results will be made publicly available in the year 2013.

Trial registration

NCT01609647
Diagnostic accuracy of a short-duration 3 Tesla magnetic resonance protocol for diagnosing stifle joint lesions in dogs with non-traumatic cranial cruciate ligament rupture
Authors: Galindo-Zamora Vladimir , Dziallas Peter , Ludwig Davina C , Nolte Ingo , Wefstaedt Patrick 
Published: March 2013

Abstract

Background
Magnetic resonance (MR) imaging is the preferred diagnostic tool to evaluate internal disorders of many joints in humans; however, the usefulness of MR imaging in the context of osteoarthritis, and joint disease in general, has yet to be characterized in veterinary medicine. The objective of this study was to assess the diagnostic accuracy of short-duration 3 Tesla MR imaging for the evaluation of cranial and caudal cruciate ligament, meniscal and cartilage damage, as well as the degree of osteoarthritis, in dogs affected by non-traumatic, naturally-occurring cranial cruciate ligament rupture (CCLR). Diagnoses made from MR images were compared to those made during surgical exploration. Twenty-one client-owned dogs were included in this study, and one experienced evaluator assessed all images.

Results
All cranial cruciate ligaments were correctly identified as ruptured. With one exception, all caudal cruciate ligaments were correctly identified as intact. High sensitivities and specificities were obtained when diagnosing meniscal rupture. MR images revealed additional subclinical lesions in both the cranial and caudal cruciate ligaments and in the menisci. There was a “clear” statistical (kappa) agreement between the MR and the surgical findings for both cartilage damage and degree of osteoarthritis. However, the large 95% confidence intervals indicated that evaluation of cartilage damage and of degree of osteoarthritis is not clinically satisfactory.

Conclusions
The presence of cruciate ligament damage and meniscal tears could be accurately assessed using the MR images obtained with our protocol. However, in the case of meniscal evaluation, occasional misdiagnosis did occur. The presence of cartilage damage and the degree of osteoarthritis could not be properly evaluated.
Ratio of preoperative atrial natriuretic peptide to brain natriuretic peptide predicts the outcome of the maze procedure in mitral valve disease
Authors: Sato Masafumi , Mikamo Akihito , Kurazumi Hiroshi , Suzuki Ryo , Murakami Masanori , Kobayashi Toshiro , Yoshimura Koich , Hamano Kimikazu 
Published: March 2013

Abstract

Background
Although the maze procedure is an established surgical treatment for eliminating atrial fibrillation (AF), its efficacy in patients with mitral valve disease has remained unsatisfactory. A useful predictive marker for the outcome of the maze procedure is needed. The aim of this study was to investigate whether the preoperative ratio of atrial natriuretic peptide (ANP) to brain natriuretic peptide (BNP) reflects atrial fibrosis and can be used to predict the maze procedure outcome in patients with mitral valve disease.

Methods
A total of 23 consecutive patients who underwent the radial approach to the maze procedure combined with mitral valve surgery were included in this study and were divided into a sinus rhythm (SR) group (n=16) and an AF group (n=7) based on postoperative cardiac rhythm. Plasma samples were obtained at rest before the operation and were analysed for ANP and BNP levels. Atrial tissue samples taken during surgery were used to quantify interstitial fibrosis.

Results
The preoperative ANP-to-BNP ratio in the SR group was significantly higher than that in the AF group (0.74 +/− 0.29 vs. 0.42 +/− 0.28, respectively; p=0.025). Receiver operating characteristic (ROC) curve analysis was used to identify factors that predict outcomes after the maze procedure. The area under the ROC curve for the ANP-to-BNP ratio (0.81) was greater than for any other preoperative factors. Moreover, the preoperative ANP-to-BNP ratio demonstrated a negative correlation with left atrial fibrosis (r=−0.69; p=0.003).

Conclusions
The preoperative ANP-to-BNP ratio can predict maze procedure outcome in patients with mitral valve disease, and it represents a potential biomarker for left atrial fibrosis.
Labor market conditions and self-employment: a Denmark-Spain comparison
Authors: Carrasco Raquel , Ejrnæs Mette 
Published: March 2013

Abstract
Among the OECD countries, Spain faces one of the highest rates of self-employment and Denmark one of the lowest, being the difference specially relevant among women. These two countries present important differences in their labor market conditions in terms of labor market flexibility, generosity of the unemployment benefits system, child care policies, and barriers to start and operate a business. In this paper we analyze if the different institutional environment and employment conditions in both countries can help to interpret the different incidence of self-employment rates. The study is carried out for men and women separately using a strictly comparable panel data set. The results indicate that in Spain self-employment seems to offer individuals who normally are considered as marginalized in the labor market a beneficial alternative to wage employment, while this pattern is not so clear in Denmark. Specifically, in Spain those individuals in the bottom part of the wage distribution and non-employees, particularly unemployed without unemployment benefits and mothers with small children, start more often their own business than in Denmark.

JEL codes

J15, J81, J61E64, J18, J38, J58, J24, J44, J62
Prevalence of PALB2 mutations in Australasian multiple-case breast cancer families
Authors: Teo Zhi L , Park Daniel J , Provenzano Elena , Chatfield Catherine A , Odefrey Fabrice A , Nguyen-Dumont Tu ,   kConFab, Dowty James G , Hopper John L , Winship Ingrid , Goldgar David E , Southey Melissa C 
Published: March 2013

Abstract
Introduction
Population-based studies of breast cancer have estimated that some PALB2 mutations confer a breast cancer risk (penetrance) comparable to the average pathogenic mutation in BRCA2. As this risk is of clinical relevance, we sought to identify mono-allelic PALB2 mutations and determine their frequencies in multiple-case breast cancer families attending Familial Cancer Clinics in Australia and New Zealand.

Methods
The youngest affected woman, not known to carry a mutation in BRCA1 or BRCA2, from 747 multiple-case breast cancer families participating in kConFab were selected for PALB2 mutation screening. The coding and flanking intronic regions of PALB2 in DNA extracted from blood were screened using high-resolution melt curve analysis with Sanger sequencing confirmation. Where possible, relatives of women found to carry PALB2 mutations were genotyped for the family-specific mutation, mutant transcripts were characterised and breast tumours arising in mutation carriers were recalled and reviewed. Missense mutations were assessed for potential to disrupt protein function via SIFT, Align GVGD and Polyphen-2.

Results
The mutation screen identified two nonsense mutations (PALB2 c.3113G>A in eight women and PALB2 c.196C>T in one woman), two frameshift mutations (PALB2 c.1947_1948insA and PALB2 c.2982_2983insT each in one woman), 10 missense variants, eight synonymous variants and four variants in intronic regions. Of the four PALB2 mutations identified that were predicted to produce truncated protein products, only PALB2 c.1947_1948insA had not previously been reported. PALB2 c.3113G>A and PALB2 c.196C>T were previously identified in the Australian population whereas PALB2 c.2982_2983insT was previously reported in the UK population. Transcripts derived from three of these mutant PALB2 alleles were vulnerable to nonsense-mediated decay. One missense mutation (PALB2 c.2993G>A) was predicted to disrupt protein function via the three in silico assessment methods applied. The majority of breast cancers arising in carriers that were available for review were high-grade invasive ductal carcinomas. Conclusions: About 1.5% (95% CI 0.6to 2.4) of Australasian multiple-case breast cancer families attending clinics are segregating protein-truncating mutations in PALB2, most being PALB2 c.3113G>A, p.Trp1038*. Given the prevalence, breast cancer risk, and tumour grade associated with this mutation, consideration of clinical PALB2 testing is warranted.
A computational framework for boosting confidence in high-throughput protein-protein interaction datasets
Authors: Hosur Raghavendra , Peng Jian , Vinayagam Arunachalam , Stelzl Ulrich , Xu Jinbo , Perrimon Norbert , Bienkowska Jadwiga , Berger Bonnie 
Published: March 2013

AbstractImproving the quality and coverage of the protein interactome is of tantamount importance for biomedical research, particularly given the various sources of uncertainty in high-throughput techniques. We introduce a structure-based framework, Coev2Net, for computing a single confidence score that addresses both false-positive and false-negative rates. Coev2Net is easily applied to thousands of binary protein interactions and has superior predictive performance over existing methods. We experimentally validate selected high-confidence predictions in the human MAPK network and show that predicted interfaces are enriched for cancer -related or damaging SNPs. Coev2Net can be downloaded at http://struct2net.csail.mit.edu.
Genome-wide association studies: what a psychiatrist needs to know
Authors: Craddock Nick 
Published: March 2013

SummaryRecent advances in high-throughput genotyping have made possible genome-wide association studies (GWAS) in which hundreds of thousands of common DNA variants spread across all the chromosomes are examined in a large number of individuals rapidly and for a realistic cost. The GWAS approach has been successfully used to identify common susceptibility variants involved in many non-psychiatric diseases, such as heart disease, diabetes, Crohn's disease, and in normal traits such as height. The typical finding is numerous susceptibility loci, each of which has a small effect size. Genome-wide association studies are similarly providing robust and replicable evidence for genes and, hence, proteins and biological systems/pathways that are involved in the aetiology and pathogenesis of major psychiatric disorders, including schizophrenia, bipolar disorder, attention-deficit hyperactivity disorder, autism and Alzheimer's disease. This article outlines for the busy psychiatrist some of the key messages emerging from this line of research.
Squaring the circle: developing clinical risk management strategies in mental healthcare organisations
Authors: Boland Billy , Bremner Sandy 
Published: March 2013

SummaryThis article explores the challenges of developing clinical risk management practice and policy within large mental healthcare organisations. The national context is outlined and requirements of organisations explained. Consideration is given to how clinical risk relates to clinical quality and the benefits of standardisation are explored. We highlight the complexities and conflicts of implementing standardised procedures, given the current evidence base, and the difficulties of applying this in clinical practice. Using concepts from strategic planning and psychology, we suggest an approach to respond to these factors at a local level to achieve better outcomes for service users and clinicians.
Adjustment disorder considered
Authors: Casey Patricia , Jabbar Faraz 
Published: March 2013

SummaryAdjustment disorder has been included in psychiatric classifications for over 40 years but has received little attention from the research community. It is particularly common in consultation liaison psychiatry. Evaluation is problematic since it may be mistaken for major depression, generalised anxiety or non-pathological reactions to stress. Its measurement by structured interview is difficult since it is not included in many instruments and, in others, cannot be diagnosed once the threshold for another disorder is reached. There are few evidence-based treatments and it is possible that these transient reactions may not require any formal intervention. Adjustment disorder generally carries an excellent prognosis but in some individuals is associated with self-harm and suicide.
Bipolar disorder and substance misuse: pathological and therapeutic implications of their comorbidity and cross-sensitisation
Authors: Post Robert M. , Kalivas Peter 
Published: March 2013

BackgroundBipolar disorder has a high co-occurrence with substance use disorders, but the pathophysiological mechanisms have not been adequately explored.AimsTo review the role of stress in the onset and recurrence of affective episodes and substance misuse.MethodWe review the mechanisms involved in sensitisation (increased responsivity) to recurrence of stressors, mood episodes and cocaine use.ResultsEvidence suggests that intermittent stressors, mood episodes and bouts of cocaine use not only show sensitisation to themselves, but cross-sensitisation to the others contributing to illness progression. Converseley, an understanding of the common mechanisms of sensitisation (such as regionally selective alterations in brain derived neurotrophic factor (BDNF) and hyperactivity of striatally based habit memories), could also result in single therapies (such as N-acetylcysteine) having positive effects in all three domains.ConclusionsThese interacting sensitisation processes suggest the importance of early intervention in attempting to prevent increasingly severe manifestations of bipolar illness and substance misuse progression.
A critical appraisal of the role of respiratory supercomplexes in mitochondria
Authors: Genova Maria Luisa , Lenaz Giorgio 
Published: March 2013

Abstract
Substantial evidence exists that the mitochondrial respiratory chain is organized in supramolecular units called supercomplexes or respirasomes. While the structural evidence of the supercomplexes is overwhelming, fewer studies have focused on their functional relevance. Although the presence of coenzyme Q channeling between complexes I and III has been ascertained, no such clear demonstration has been carried out for cytochrome c between complexes III and IV, at least in mammalian mitochondria. This review also discusses the implications concerning the number of respiratory complexes organized in supercomplexes and the possibility that they represent associations in dynamic equilibrium with the individual complexes.
Crystal structure of 1-methyl-5-(4-(1-methyl-1H-tetrazol-5-ylthio) butylthio)-1H-tetrazole, C8H14N8S2
Authors: Xia Daocheng , Feng Feng 
Published: March 2013

Abstract C8H14N8S2, monoclinic, P21/n (no. 14), a = 8.455(1) Å, b = 9.7574(8) Å, c = 8.9024(9) Å, β = 116.23(1)°, V = 658.8 Å3, Z = 2, Rgt(F) = 0.0528, wRref(F2) = 0.1224, T = 293 K.
Crystal structure of aqua-di-μ-hydroxy-bis(3-(pyridin-3-yl-oxy)-benzene- 1,2-dicarboxylato)tri-zinc(II), C26H18N2O13Zn3
Authors: Li Guan-Feng , Feng Xun , Shi Zhi-Qiang , Xie Shi-Yu 
Published: March 2013

Abstract C26H18N2O13Zn3, monoclinic, C2/c (no. 15), a = 24.794(5) Å, b = 9.362(2) Å, c = 11.950(2) Å, β = 112.452(4)°, V = 2563.7 Å3, Z = 4, Rgt(F) = 0.0681, wRref(F2) = 0.1855, T = 293 K.
Crystal structure of tert-butyl-3-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropurin- 7-yl)propanoate, C14H20N4O4
Authors: Liu Jian-Ping , Wang Chao , Yuan Wei 
Published: March 2013

Abstract C14H20N4O4, orthorhombic, Pccn (no. 56), a = 25.821(3) Å, b = 6.9466(8) Å, c = 17.551(2) Å, V = 3148.1 Å3, Z = 8, Rgt(F) = 0.0456, wRref(F2) = 0.1405, T = 298 K.
Crys tal struc ture of 2,6-diiodo-8-phenyl-BODIPY, C19H17BF2I2N2
Authors: Li Xiaochuan , Jiang Wenjuan , Li Yajuan , Zhang Junna , Son Young-A 
Published: March 2013

Abstract C19H17BF2I2N2, monoclinic, P21/c1 (no. 14), a = 15.326(2) A, b = 7.5985(8) A, c = 17.189(2) A, β = 91.834(1)°, V = 2000.7 A3, Z = 4, Rgt(F) = 0.0270, wRref(F2) = 0.0680, T = 296 K.
Crystal structure of 2-(4-diethylamino-2-hydroxyphenyl)-benzoxazole, C17H18N2O2
Authors: Li Xiaochuan , Li Yajuan , Zhang Junna , Son Young-A 
Published: March 2013

Abstract C17H18N2O2, monoclinic, P21/n (no. 14), a = 7.192(1) Å, b = 14.948(2) Å, c = 14.001(2) Å, β = 94.520(2)°, V = 1500.5 Å3, Z = 4, Rgt(F) = 0.0533, wRref(F2) = 0.1685, T = 296 K.
Redetermination of the structure of 1-(4-benzyloxyphenyl)-2-bromopropan- 1-one, C16H15BrO2
Authors: Kaur Manpreet , Yathirajan Hemmige S. , Dayananda Alaloor S. , Gerber Thomas , Hosten Eric , Betz Richard 
Published: March 2013

Abstract C16H15BrO2, monoclinic, P21/c (no. 14), a = 4.8925(2) Å, b = 9.6531(3) Å, c = 29.896(1) Å, β = 97.802(2)°, V = 1398.9 Å3, Z = 4, Rgt(F) = 0.0445, wRref(F2) = 0.0894, T = 200 K
Crystal structure of 3,4,5-trimethoxy-N-(4-(4-methoxyphenyl)-6-phenyl pyridin-2-yl)benzamide, C56H52N4O10
Authors: Guo Chang-Bin , Hou Zhen-Geng , He Yang 
Published: March 2013

Abstract C56H52N4O10, monoclinic, P21/c (no. 14), a = 13.448(3) Å, b = 18.975(4) Å, c = 19.670(4) Å, β = 105.63(1)°, V = 4833.8 Å3, Z = 4, Rgt(F) = 0.0515, wRref(F2) = 0.1789, T = 296 K
Crystal structure of lithium disulfate, Li2[S2O7], Li2O7S2
Authors: Logemann Christian , Witt Julia , Wickleder Mathias S. 
Published: March 2013

Abstract Li2O7S2, orthorhombic, Pnma (no. 62), a = 13.177(2) Å, b = 8.2516(7) Å, c = 4.8547(4) Å, V = 527.8 Å3, Z = 4, Rgt(F) = 0.0338, wRref(F2) = 0.1054, T = 153 K.
Crystal structure of di-acetato-bis-pyridine-palladium(II), [Pd(C2H3O2)2(C5H5N)2], C14H16N2O4Pd
Authors: Gudenschwager Marit , Wickleder Mathias S. 
Published: March 2013

AbstractC14H16N2O4Pd, monoclinic, P21/c (no. 14), a = 7.7797(4) Å, b = 11.7520(6) Å, c = 8.0914(4) Å, β = 90.754(2)°, V = 739.7 Å3, Z = 2, Rgt(F) = 0.0186, wRref(F2) = 0.0437, T = 153 K.