bluuebunny/crossref_metadata_2025_split huggingface dataset:
Superficialization of the Radial Artery – An Alternative Secondary Vascular Access
Authors: Weyde Wacław , Kusztal Mariusz , Gołębiowski Tomasz , Letachowicz Krzysztof , Letachowicz Waldemar , Wątorek Ewa , Madziarska Katarzyna , Krajewska Magdalena , Szyber Przemysław , Janczak Dariusz , Klinger Marian 
Published: January 2013

Purpose The standard approach in patients with a clotted arteriovenous fistula (AVF) on the forearm is the creation of another vascular access on the arm using the patient's own vessels or a prosthetic graft. Here we propose another option as secondary angioaccess for chronic hemodialysis (HD): superficialization of the radial artery. Methods Indications for the procedure were 1) long-standing forearm AVF that has irreversibly clotted and/or central vein stenosis resistant to angioplasty; 2) patients who have no other prospect for forearm or even brachial AVF. The procedure was undertaken in 7 chronic HD patients dialyzed by forearm AVF for 27±26 months. Results In one case the superficialization was abandoned intra-operatively due to small diameter of the artery (<4 mm). Five of 6 elevated arteries were patent and the follow-up period ranges from 11 to 15 (median 12) months. In 1 male patient with prothrombin G20210a mutation the artery clotted after 13 months of usage. Conclusions Superficialized radial artery was successfully used for hemodialysis over one year. The only prerequisite for safe repeated puncture is a patent and enlarged radial artery. Due to avoidance of arteriovenous shunt this access type may be particularly suitable for patients with cardiac failure.
Área de Influência de um Bairro sob a Ótica de Conceitos de Espaço de Atividades
Authors: Faé Maria Inês , Simonelli Cristiano Hemerly 
Published: January 2013

Este artigo aborda conceitos de espaço de atividades e de área de influência direta de empreendimentos para subsidiar uma análise da atração de indivíduos para um dado bairro. Por definição esse espaço de atividades coincide com a área de Influência Direta, porém não a de um Empreendimento, mas sim a de um bairro a partir das características de infraestrutura urbana ofertadas como serviços, comércio, lazer, educação, saúde, etc. Um estudo de caso permite o traçado de linhas de desejo de viagens entre localidades o que complementa a análise conceitual realizada.
Assessment of diagnosis of inflammatory breast cancer cases at two cancer centers in Egypt and Tunisia
Authors: Schairer Catherine , Soliman Amr S. , Omar Sherif , Khaled Hussein , Eissa Saad , Ayed Farhat Ben , Khalafallah Samir , Ayoub Wided Ben , Kantor Elizabeth D. , Merajver Sofia , Swain Sandra M. , Gail Mitchell , Brown Linda Morris 
Published: January 2013

AbstractThe diagnosis of inflammatory breast cancer (IBC) is largely clinical and therefore inherently somewhat subjective. The objective of this study was to evaluate the diagnosis of IBC at two centers in North Africa where a higher proportion of breast cancer is diagnosed as IBC than in the United States (U.S.). Physicians prospectively enrolled suspected IBC cases at the National Cancer Institute (NCI) – Cairo, Egypt, and the Institut Salah Azaiz (ISA), Tunisia, recorded extent and duration of signs/symptoms of IBC on standardized forms, and took digital photographs of the breast. After second‐level review at study hospitals, photographs and clinical information for confirmed IBC cases were reviewed by two U.S. oncologists. We calculated percent agreement between study hospital and U.S. oncologist diagnoses. Among cases confirmed by at least one U.S. oncologist, we calculated median extent and duration of signs and Spearman correlations. At least one U.S. oncologist confirmed the IBC diagnosis for 69% (39/50) of cases with photographs at the NCI‐Cairo and 88% (21/24) of cases at the ISA. All confirmed cases had at least one sign of IBC (erythema, edema, peau d'orange) that covered at least one‐third of the breast. The median duration of signs ranged from 1 to 3 months; extent and duration of signs were not statistically significantly correlated. From the above‐mentioned outcomes, it can be concluded that the diagnosis of a substantial proportion of IBC cases is unambiguous, but a subset is difficult to distinguish from other types of locally advanced breast cancer. Among confirmed cases, the extent of signs was not related to delay in diagnosis.
Flickr images: What & why museums share
Authors: Beaudoin Joan E. , Bosshard Cécile 
Published: January 2013

AbstractThis paper presents the results of a study which explored the use of Flickr by cultural heritage institutions. The study examined two aspects of museums' use of Flickr: the content of images posted by museums, and the reasons behind sharing their images to the social media site. Images were categorized by the researchers into nine classes based on their visible content, and a brief questionnaire was used to gather data about the image sharing process from museum personnel. The findings reveal that imagery of people visiting the museum and taking part in museum events predominated in the total number of images posted by museums (54% of the total). The images posted to Flickr were most often selected by a single individual at the institution. The particular images posted to Flickr were chosen for a variety of reasons, the most common of these being that they were newsworthy recent events at the museum (e.g. openings, exhibitions, lectures, etc.), or that the staff found the images to have strong affective characteristics. In the responses from museum staff regarding the motivations behind posting the images to Flickr two replies were most commonly given: to provide access to the images, and to take advantage of the technical benefits provided by the photo‐sharing service.
Identifying content and levels of representation in scientific data
Authors: Wickett Karen M. , Sacchi Simone , Dubin David , Renear Allen H. 
Published: January 2013

AbstractHeterogeneous digital data that has been produced by different communities with varying practices and assumptions, and that is organized according to different representation schemes, encodings, and file formats, presents substantial obstacles to efficient integration, analysis, and preservation. This is a particular impediment to data reuse and interdisciplinary science. An underlying problem is that we have no shared formal conceptual model of information representation that is both accurate and sufficiently detailed to accommodate the management and analysis of real world digital data in varying formats. Developing such a model involves confronting extremely challenging foundational problems in information science. We present two complementary conceptual models for data representation, the Basic Representation Model and the Systematic Assertion Model. We show how these models work together to provide an analytical account of digitally encoded scientific data. These models will provide a better foundation for understanding and supporting a wide range of data curation activities, including format migration, data integration, data reuse, digital preservation strategies, and assessment of identity and scientific equivalence.
A Higher Glomerular Filtration Rate Predicts Low Risk of Developing Chronic Kidney Disease in Living Kidney Donors
Authors: Tsai Shang‐Feng , Shu Kuo‐Hsiung , Wu Ming‐Ju , Ho Hao‐Chung , Wen Mei‐Chin , Su Chung‐Kwang , Lian Jong‐Da , Chen Cheng‐Hsu 
Published: January 2013

AbstractBackgroundThe risk of developing chronic kidney disease (CKD) among living kidney donors (LKDs) is seldom included in evaluations of patients’ outcomes. Potential risk factors and new criteria for estimating the glomerular filtration rate (eGFR) indexed for body surface area (BSA) were investigated with a view to prevent the development of CKD in LKDs.MethodsWe conducted a retrospective study of LKDs from May 1983 to March 2011. The Mann–Whitney U test and χ2 test were used to analyze the male versus female groups. Survival analysis was plotted as CKD‐free survival and analyzed separately by different eGFR index classifications. The Cox regression model was used to identify potential risk factors for development of CKD.ResultsA total of 105 LKDs with a mean age of 46.3 ± 12.5 years had a mean eGFR indexed for BSA of 88.9 ± 21.5 ml/min per 1.73 m2. After a mean duration of 5.4 ± 4.9 years’ follow‐up, eGFR dropped to 61.4 ± 16.4 ml/min per 1.73 m2 (p = 0.002). Median CKD‐free survival was only 5.7 years. The difference between eGFR ≥ 80 ml/min per 1.73 m2 and <80 ml/min per 1.73 m2 was not statistically significant (p = 0.980). Multivariate Cox regression analysis showed that higher eGFR at donation (HR = 0.952, p = 0.0199) could be a protective factor. The receiver operating characteristic (ROC) curve for initial eGFR with best sensitivity of 52.78 % and specificity of 81.40 % was obtained with a cutoff value of 90.2 ml/min per 1.73 m2 for preoperative eGFR. An eGFR of 90 ml/min per 1.73 m2 yielded a significant survival curve (p = 0.0199) after 21 years of follow‐up. Further classifications of eGFR >90 ml/min per 1.73 m2 into 90–99 ml/min per 1.73 m2, 100–109 ml/min per 1.73 m2, and ≥110 ml/min per 1.73 m2 were examined, but this survival curve was not statistically significant (p = 0.1247).ConclusionsLiving kidney donors will develop CKD after a long duration of follow‐up if there is insufficiently high eGFR at donation. An eGFR above 90 ml/min per 1.73 m2 before donation is the only factor that predicts prevention of CKD. Larger studies with longer duration of follow‐up are necessary to clarify the clinical outcome of this postoperative CKD group, especially for patients with eGFR between 80 and 90 ml/min per 1.73 m2.
Hausarztzentrierte Versorgung aus Sicht der AOK Baden-Württemberg
Authors: Hermann Christopher , Graf Jürgen 
Published: January 2013

Einleitung
Die AOK Baden-Württemberg startete für ihre Versicherten am 1. Oktober 2008 gemeinsam mit ihren Vertragspartnern Hausärzteverband und MEDI die deutschlandweite Premiere zur hausarztzentrierten Versorgung (HZV) mit Budgetbereinigung. Der mittlerweile evaluierte Vertrag mit 1,1 Millionen teilnehmenden Versicherten und 3.500 aktiven Hausärzten setzt Maßstäbe und bestätigt die Intention des Gesetzgebers zur Stärkung der hausärztlichen Versorgung in einer älter werdenden Gesellschaft.
Proust at the Ballet: Literature and Dance in Dialogue
Authors: Schmid Marion 
Published: January 2013

Abstract

This article examines French choreographer Roland Petit's ballet adaptation of
À la recherche du temps perdu
as an example of the little-researched interartistic relations between literature and dance. Drawing on translation theory and recent dance scholarship, it argues that Petit's ‘lecture dancée’,
Proust ou les intermittences du cœur
, offers a bold critical reading of the source text that challenges conservative public perceptions of Proust through its foregrounding of the darker side of human passions in the text and its focus on homosexuality as a major theme. By lifting the novel out of its traditional medium, the ballet brings to the fore aspects of the work that criticism tends to overlook: Proust's interest in the body in motion, the gestural and choreographic qualities of his writing, the marked theatricality of some of the text's most prominent scenes. Not bound by the strictures of faithfulness, Petit signs a performance that extracts Proustian ‘essences’ in the interstices between text and performance.
Phylogenetic Investigations on Ten Genera of Tintinnid Ciliates (Ciliophora: Spirotrichea: Tintinnida), Based on Small Subunit Ribosomal RNA Gene Sequences
Authors: Xu Dapeng , Sun Ping , Warren Alan , Hoon Noh Jae , Lim Choi Dong , Kyoon Shin Mann , Ok Kim Young 
Published: January 2013

AbstractTintinnida is a diverse taxon that accommodates over 1,500 morphospecies, which is an important component of marine planktonic food webs. However, evolutionary relationships of tintinnids are poorly known because molecular data of most groups within this order are lacking. In our study, the small subunit (SSU) rRNA genes representing 10 genera, 5 families of Tintinnida were sequenced, including the first SSU rRNA gene sequences for Coxliella, Dadayiella, Epiplocyloides, and Protorhabdonella, and phylogenetic trees were constructed to assess their intergeneric relationships. Phylogenies inferred from different methods showed that (1) Three newly sequenced Eutintinnus species fell into Eutintinnus clade forming a sister group to the clade containing Amphorides, Steenstrupiella, Amphorellopsis, and Salpingella; (2) Surprisingly, the genetic distances between Amphorides amphora and Amphorellopsis acuta population 1 was even smaller than that between the two populations of Amphorellopsis acuta, casting doubt on the validity of Amphorides and Amphorellopsis as presently defined; (3) The SSU rRNA sequences of Dadayiella ganymedes and Parundella aculeata were almost identical. Therefore, Parundella ganymedes novel combination is proposed; (4) Coxliella, which is currently assigned within Metacylididae, branched instead with some Tintinnopsis species. Furthermore, the validation of Coxliella, which was considered to be a “questionable” genus, was confirmed based on evidences from morphology, ecology, and molecular data; (5) Protorhabdonella and Rhabdonella showed rather low intergeneric distance and grouped together with strong support suggesting that Rhabdonellidae is a well‐defined taxon; and (6) Epiplocyloides branched with species in Cyttarocylididae indicating their close relationship.
CHILE: An Evidence‐Based Preschool Intervention for Obesity Prevention in Head Start
Authors: Davis Sally M. , Sanders Sarah G. , FitzGerald Courtney A. , Keane Patricia C. , Canaca Glenda F. , Volker‐Rector Renee 
Published: January 2013

ABSTRACTBACKGROUNDObesity is a major concern among American Indians and Hispanics. The Child Health Initiative for Lifelong Eating and Exercise (CHILE) is an evidence‐based intervention to prevent obesity in children enrolled in 16 Head Start (HS) Centers in rural communities. The design and implementation of CHILE are described.METHODSCHILE uses a socioecological approach to improve dietary intake and increase physical activity. The intervention includes: a classroom curriculum; teacher and food service training; family engagement; grocery store participation; and health care provider support.RESULTSLessons learned from CHILE include the need to consider availability of recommended foods; the necessity of multiple training sessions for teachers and food service; the need to tailor the family events to local needs; consideration of the profit needs of grocery stores; and sensitivity to the time constraints of health care providers.CONCLUSIONSHS can play an important role in preventing obesity in children. CHILE is an example of a feasible intervention that addresses nutrition and physical activity for preschool children that can be incorporated into HS curricula and aligns with HS national performance standards.
Characteristics of Condom and Lubricant Use Among a Nationally Representative Probability Sample of Adults Ages 18–59 in the United States
Authors: Herbenick Debby , Schick Vanessa , Reece Michael , Sanders Stephanie A. , Smith Nicole , Dodge Brian , Fortenberry J. Dennis 
Published: January 2013

ABSTRACT

Introduction
Although most Americans have used condoms and/or lubricant during sex, little is known about the context of sexual events that involve the use of such products outside of experimentally manipulated studies.

Aims
To assess, in a nationally representative study of men and women in the United States ages 18–59, the characteristics of condom and lubricant use during participants' most recent sexual event and the relationship of their condom and lubricant use to event-level ratings of sexual quality.

Methods
Data are from the National Survey of Sexual Health and Behavior, which involved the administration of an online questionnaire to a nationally representative probability sample of the U.S. adults.

Main Outcome Measures
Sociodemographic items: event-level items related to sexual behavior, condom use, lubricant use, and participants' perceptions of their arousal, pleasure, ease of erection or lubrication, and pain associated with sex.

Results
During their most recent sexual experience, 27.5% of men (N = 237) and 22.3% of women (N = 175) reported using a condom. More than twice as many women as men were unsure whether the condom was lubricated (26.6% vs. 11.4%) and the material it was made of (23.6% vs. 8.9%). Participants consistently rated sex to be arousing and pleasurable whether or not they used condoms or lubricant. No significant differences were found in regard to men's ratings of the ease of their erections based on condom and lubricant use.

Conclusions
Although some have concerns about how condoms or lubricants may impact their enjoyment of sex, in a nationally representative sample of men and women ages 18–59, ratings of sex were largely quite high, with few differences based on condom and lubricant use. Women, more often than men, reported being unsure about the type of condom and lubricant used, which has implications for patient education.
Assessment of Brain Metabolites Change during Visual Sexual Stimulation in Healthy Women Using Functional MR Spectroscopy
Authors: Kim Tae-Hoon , Kang Heoung-Keun , Jeong Gwang-Woo 
Published: January 2013

ABSTRACT

Introduction
Numerous functional magnetic resonance imaging (fMRI) studies demonstrated the key brain areas associated with visual sexual arousal. However, the changes in brain metabolites involved in sexual stimuli have not been reported.

Aim
This study utilized functional MR spectroscopy (fMRS) to evaluate the changes in brain metabolites associated with sexual arousal induced by stimulation with erotic video clips in healthy women.

Methods
Twenty-three healthy, right-handed women (38.4 ± 10.0 years) participated in 1H-fMRS and fMRI studies. T1 and T2 MR images were used for voxel localization of the anterior cingulate gyrus, which is one of the most important key centers associated with sexual arousal.

Main Outcome Measures
The changes of brain metabolites were measured using 1H-fMRS during time-course activation: “before,” “during,” and “after” visual sexual stimulation. The time-course variation of the brain metabolites was analyzed by the repeated-measures analysis of variance.

Results
The CVmean of all the metabolites had &lt;30% (range, 9–29%). The ICCs of α-glutamine-glutamate (Glx), choline (Cho), β·γ-Glx, N-acetylaspartate (NAA) and lactate (Lac) all exceeded 0.6. However, myo-inositol (mI) and lipid (Lip) were &lt;0.6. The concentration of brain metabolites including α-Glx, β·γ-Glx, Cho, and Lac comparatively increased significantly during visual sexual stimulation.

Conclusions
1H-fMRS, for the first time, was applied to assess the brain metabolic changes during visually-evoked sexual arousal. The fMRS outcomes in relation to functional MRI data will be useful to understand the neural mechanism associated with sexual arousal.
LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis
Authors: Cox Thomas R. , Bird Demelza , Baker Ann-Marie , Barker Holly E. , Ho Melisa W-Y. , Lang Georgina , Erler Janine T. 
Published: January 2013

Abstract
Tumor metastasis is a highly complex, dynamic, and inefficient process involving multiple steps, yet it accounts for more than 90% of cancer-related deaths. Although it has long been known that fibrotic signals enhance tumor progression and metastasis, the underlying molecular mechanisms are still unclear. Identifying events involved in creating environments that promote metastatic colonization and growth are critical for the development of effective cancer therapies. Here, we show a critical role for lysyl oxidase (LOX) in establishing a milieu within fibrosing tissues that is favorable to growth of metastastic tumor cells. We show that LOX-dependent collagen crosslinking is involved in creating a growth-permissive fibrotic microenvironment capable of supporting metastatic growth by enhancing tumor cell persistence and survival. We show that therapeutic targeting of LOX abrogates not only the extent to which fibrosis manifests, but also prevents fibrosis-enhanced metastatic colonization. Finally, we show that the LOX-mediated collagen crosslinking directly increases tumor cell proliferation, enhancing metastatic colonization and growth manifesting in vivo as increased metastasis. This is the first time that crosslinking of collagen I has been shown to enhance metastatic growth. These findings provide an important link between ECM homeostasis, fibrosis, and cancer with important clinical implications for both the treatment of fibrotic disease and cancer. Cancer Res; 73(6); 1721–32. ©2012 AACR.
Enhancement of invasion of hepatocellular carcinoma cells through lysophosphatidic acid receptor
Authors: Lou Lianqing , Chen Yong Xin , Jin Lingzhen , Li Xiaofei , Tao Xingfei , Zhu Jinhong , Chen Xiangyi , Wu Shuang , Ye Weiwei , He Jinke , Ding Guoqiang 
Published: January 2013

Objectives Lysophosphatidic acid (LPA) is a bioactive lipid mediator involved in tumour progression, cell invasion and metastasis. The mechanism of action of LPA in the invasive and metastatic capacity of human hepatocellular carcinoma (HCC) is not fully understood. This study investigated the effects of LPA on HCC cell invasion and induction of matrix metalloproteinase (MMP) −2 and −9. Methods LPA receptor levels in HCC cell lines were detected by Western blot analysis; HCC cell invasion was analysed by the Transwell® system. The LPA receptor blocker Ki16425 was used to determine whether HCC cell invasion was LPA dependent. Expression of the MMP2 and MMP9 genes in HCC cells was determined by real-time quantitative reverse transcription–polymerase chain reaction (qPCR). Results LPA increased HCC cell invasion, which was LPA-receptor dependent. Real-time RT–qPCR showed that LPA increased MMP9, but not MMP2, expression in HCC cells. Pharmacological inhibition of LPA receptors with Ki16452 significantly attenuated LPA-induced HCC cell invasion. Conclusions HCC invasiveness is facilitated by LPA and may be relevant to tumour progression. Thus, LPA receptors may be a potential therapeutic target for HCC.
Factors influencing delayed extubation after infratentorial craniotomy for tumour resection: a prospective cohort study of 800 patients in a Chinese neurosurgical centre
Authors: Cai Ye‐Hua , Zeng Heng-Yu , Shi Zhong-Hua , Shen Jing , Lei Yan-Ni , Chen Bi-Yao , Zhou Jian-Xin 
Published: January 2013

Objectives To investigate prospectively the rate of, and factors influencing, delayed extubation following infratentorial craniotomy in a Chinese neurosurgical centre. Methods Patients undergoing infratentorial craniotomy for tumour resection were prospectively enrolled and stratified according to whether extubation was attempted in the operating theatre (early extubation) or not (delayed extubation). Pre- and intraoperative variables were collected and analysed. Multiple logistic regression analysis was performed, to identify factors related to delayed extubation. Results The study included 800 patients, 398 (49.8%) of whom underwent delayed extubation. The overall rate of extubation failure was 3.6%. Independent factors related to delayed extubation were: preoperative lower cranial nerve dysfunction; hydrocephalus; tumour location; duration of surgery ≥6 h; estimated blood loss ≥1000 ml. Compared with patients in the early extubation group, those in the delayed extubation group had a higher rate of pneumonia, longer intensive care unit and postoperative hospital stays, and higher hospitalization costs. Conclusions Brain stem and lower cranial nerve function were the main factors affecting extubation decision-making. Further research is required, to establish criteria for delayed extubation following infratentorial craniotomy.