bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-graduate and graduate entry medical students attitudes to psychiatry
Authors: Pillay S. M. , Sundram F. , Mullins D. , Rizvi N. , Grant T. , Boohan M. , Murphy K. C. 
Published: September 2013

ObjectiveGraduate entry medical students’ views of psychiatry may differ from those of school leavers. This study hypothesised that (i) exposure to a psychiatry attachment is associated with a positive change in attitudes towards psychiatry in both graduate entry and non-graduate entry students, (ii) graduate entry students exhibit a more positive attitude to psychiatry compared to non-graduate entry students and (iii) graduate entry students are more interested in a career in psychiatry than non-graduate entry students.MethodsIn this study 247 medical students (118 females and 129 males) completing their psychiatry rotation were invited to complete questionnaires examining career choice, attitudes to psychiatry and career attractiveness for a range of specialties including surgery, medicine, general practice and psychiatry before and after their psychiatry attachment. Questionnaires were distributed prior to commencement of their attachment and redistributed on the final day of the attachment.ResultsOf the 165 participants in the study, 75 students entered medicine via the traditional route (without a primary degree), 49 entered via the graduate entry programme and 41 had a primary degree. Overall, medical students displayed positive attitudes towards psychiatry. However, while there was an improvement in attitudes towards psychiatry and the career attractiveness of psychiatry on completion of the rotation, no differences were found between graduate and non-graduate entry students. Psychiatry and general practice had lower ratings for career attractiveness than other specialities. No significant changes were found in the first and second choice of specialty.ConclusionOur results show that improvements in attitude and career attractiveness do not necessarily correlate with increased choice of psychiatry as a specialty. Graduate entry has been considered a possible opportunity for increasing recruitment in psychiatry but our results suggest that this may not be the case. Follow-up studies are required to determine whether career attractiveness correlates with future career choice.
Postprandial response of plasma IL-6 to isoenergetic meals rich in casein or potato singly and combined in obese women
Authors: Manning Patrick J. , Sutherland Wayne H. F. , de Jong Sylvia A. , Ryalls Anne R. , Berry Elizabeth A. 
Published: September 2013

AbstractMilk consumption decreases inflammatory stress in overweight and obese subjects. Casein is the major protein in milk and enhances the secretion of insulin that has anti-inflammatory activity. The aim of the present study was to compare the acute effect of meals rich in casein and carbohydrate and a combination of both nutrients on postprandial plasma concentrations of IL-6, a marker of inflammation, in obese women. A total of twenty-five obese women aged 38–68 years consumed isoenergetic meals rich in potato (POT) or casein (CA) or a combination of both these meals (POT + CA), in random order in a cross-over trial. After an overnight fast, blood samples were collected before and at 1 and 4 h after the meals and circulating concentrations of IL-6, glucose, insulin and NEFA were measured. Plasma IL-6 concentrations increased significantly (P < 0·001) during 4 h after the meals. The AUC of postprandial IL-6 concentrations was not significantly (P = 0·77) different among the meals. Postprandial serum insulin concentration AUC was significantly higher during the POT + CA meal compared with the POT meal (P = 0·001) and the CA meal (P < 0·05), which in turn was significantly higher than the POT meal (P < 0·05). These data show that while ingestion of CA alone or combined with POT acutely increases circulating insulin concentrations, it does not appreciably alter the postprandial increase in plasma IL-6 concentrations in obese women.
Effects of dietary plant meal and soya-saponin supplementation on intestinal and hepatic lipid droplet accumulation and lipoprotein and sterol metabolism in Atlantic salmon (Salmo salarL.)
Authors: Gu Min , Kortner Trond M. , Penn Michael , Hansen Anne Kristine , Krogdahl Åshild 
Published: September 2013

Altered lipid metabolism has been shown in fish fed plant protein sources. The present study aimed to gain further insights into how intestinal and hepatic lipid absorption and metabolism are modulated by plant meal (PM) and soya-saponin (SA) inclusion in salmon feed. Post-smolt Atlantic salmon were fed for 10 weeks one of four diets based on fishmeal or PM, with or without 10 g/kg SA. PM inclusion resulted in decreased growth performance, excessive lipid droplet accumulation in the pyloric caeca and liver, and reduced plasma cholesterol levels. Intestinal and hepatic gene expression profiling revealed an up-regulation of the expression of genes involved in lipid absorption and lipoprotein (LP) synthesis (apo, fatty acid transporters, microsomal TAG transfer protein, acyl-CoA cholesterol acyltransferase, choline kinase and choline-phosphate cytidylyltransferase A), cholesterol synthesis (3-hydroxy-3-methylglutaryl-CoA reductase) and associated transcription factors (sterol regulatory element-binding protein 2 and PPARγ). SA inclusion resulted in reduced body pools of cholesterol and bile salts. The hepatic gene expression of the rate-limiting enzyme in bile acid biosynthesis (cytochrome P450 7A1 (cyp7a1)) as well as the transcription factor liver X receptor and the bile acid transporterabcb11(ATP-binding cassette B11) was down-regulated by SA inclusion. A significant interaction was observed between PM inclusion and SA inclusion for plasma cholesterol levels. In conclusion, gene expression profiling suggested that the capacity for LP assembly and cholesterol synthesis was up-regulated by PM exposure, probably as a compensatory mechanism for excessive lipid droplet accumulation and reduced plasma cholesterol levels. SA inclusion had hypocholesterolaemic effects on Atlantic salmon, accompanied by decreased bile salt metabolism.
THE EFFECTS OF ALUMINIUM ON THE PHOTOSYNTHETIC APPARATUS OF TWO RICE CULTIVARS
Authors: JÚNIOR E. M. FONSECA , CAMBRAIA J. , RIBEIRO C. , OLIVA M. A. , OLIVEIRA J. A. , DaMATTA F. M. 
Published: September 2013

SUMMARYWe aimed to evaluate aluminium (Al) effects on the photosynthetic apparatus of two rice cultivars with contrasting tolerances to Al. Nine-days-old seedlings were exposed to 0 or 1 mM Al for 10 days, and then dry mass, Al and chloroplastidic pigment contents and photosynthetic parameters were determined. Al accumulated mainly in the roots of the Al-treated plants. In the leaves, Al increased only in the sensitive cultivar, but there was no difference between the cultivars in Al-treated plants. The root and leaf dry mass, the net carbon assimilation rate, stomatal conductance and internal CO2 concentration were all reduced in response to Al application, but only in the sensitive cultivar. Both the initial fluorescence and potential photochemical efficiency of photosystem II were unresponsive to the Al treatments, regardless of the cultivar. In the Al-sensitive cultivar, Al provoked significant decreases in the photochemical quenching coefficient, quantum yield of photosystem II electron transport and apparent electron transport rate, in parallel to an unaltered non-photochemical quenching coefficient. All of these parameters remained at the control levels in the tolerant cultivar. The chloroplastidic pigment content increased only in the Al-tolerant cultivar, whereas it remained unaltered after Al treatment in the sensitive cultivar. In conclusion, Al induced stomatal and (most likely) photochemical constraints on photosynthesis but with no apparent signs of photoinhibition in the Al-sensitive cultivar. Despite the similar Al levels of the cultivars, unchanging biomass accumulation or photosynthetic performance in the tolerant cultivar challenged with Al highlights its higher intrinsic ability to cope with Al stress.
Composing and performing in the key stage 3 classroom: a study using multi-trait, multi-method analysis
Authors: Fowler Andrew 
Published: September 2013

‘Music is both a creative and a performing art’ (Hallam, 2006, p. 70). Many musicians and music educators maintain that composing and performing, although related, are essentially different aspects of musical activity. In the professional musical sphere, composition and performance are almost invariably separated; academic studies have treated them discretely; GCSE and ‘A’ level specifications assess them distinctly, and many music teachers assess them in the classroom as if they were separate disciplines. It is common practice for students in the lower secondary school in England to work in a more integrated way, however (Philpott, 2001; Major, 2008), composing, performing to the class, and appraising each others’ work. Recently produced assessment guidelines for secondary school music teachers in England (NAME, 2011) encourage this more integrated view, accepting the assumption made by Swanwick and Franca (1999, p. 12) that ‘musical understanding is a broad conceptual dimension’ by considering composing and performing as inter-linked ways of demonstrating and communicating musicality. This study sets out to investigate the links between composing and performing in the secondary school classroom, through peer-rating, teacher rating and students’ self-report attitudinal questionnaires, analysing these using a multi-trait, multi-method technique.Evidence for convergent validity was found between performing and composing in the classroom, suggesting that they are closely linked and may indeed be related parts of the same trait. This may have implications for the ways in which composing and performing are taught and assessed. A larger-scale study could be undertaken to investigate this further.
Stability for the spherically symmetric Einstein–Vlasov system–a coercivity estimate
Authors: HADŽIĆ MAHIR , REIN GERHARD 
Published: September 2013

AbstractThe stability of static solutions of the spherically symmetric, asymptotically flat Einstein–Vlasov system is studied using a Hamiltonian approach based on energy-Casimir functionals. The main results are a coercivity estimate for the quadratic part of the expansion of the natural energy-Casimir functional about an isotropic steady state, and the linear stability of such steady states. The coercivity bound shows in a quantified way that this quadratic part is positive definite on a class of linearly dynamically accessible perturbations, provided the particle distribution of the steady state is a strictly decreasing function of the particle energy and provided the steady state is not too relativistic. In contrast to the stability theory for isotropic steady states of the gravitational Vlasov-Poisson system the monotonicity of the particle distribution alone does not determine the stability character of the state, a fact which was observed by Ze'ldovitch et al. in the 1960's. The result in an essential way exploits the non-linear structure of the Einstein equations satisfied by the steady state and is not just a perturbation result of the analogous coercivity bounds for the Newtonian case. It should be an essential step in a fully non-linear stability analysis for the Einstein–Vlasov system.
Factors Associated with High-Rise Evacuation: Qualitative Results from the World Trade Center Evacuation Study
Authors: Gershon Robyn R.M. , Qureshi Kristine A. , Rubin Marcie S. , Raveis Victoria H. 
Published: September 2013

AbstractIntroduction:Due to the fact that most high-rise structures (i.e., >75 feet high, or eight to ten stories) are constructed with extensive and redundant fire safety features, current fire safety procedures typically only involve limited evacuation during minor to moderate fire emergencies. Therefore, full-scale evacuation of high-rise buildings is highly unusual and consequently, little is known about how readily and rapidly high-rise structures can be evacuated fully. Factors that either facilitate or inhibit the evacuation process remain under-studied.Objective:This paper presents results from the qualitative phase of the World Trade Center Evacuation Study, a three-year, five-phase study designed to improve our understanding of the individual, organizational, and environmental factors that helped or hindered evacuation from the World Trade Center (WTC) Towers 1 and 2, on 11 September 2001.Methods:Qualitative data from semi-structured, in-depth interviews and focus groups involving WTC evacuees were collected and analyzed.Results:On the individual level, factors that affected evacuation included perception of risk (formed largely by sensory cues), preparedness training, degree of familiarity with the building, physical condition, health status, and footwear. Individual behavior also was affected by group behavior and leadership. At the organizational level, evacuation was affected by worksite preparedness planning, including the training and education of building occupants, and risk communication. The environmental conditions affecting evacuation included smoke, flames, debris, general condition and degree of crowdedness on staircases, and communication infrastructure systems (e.g., public address, landline, cellular and fire warden's telephones).Conclusions:Various factors at the individual, organizational, and environmental levels were identified that affected evacuation. Interventions that address the barriers to evacuation may improve the full-scale evacuation of other high-rise buildings under extreme conditions. Further studies should focus on the development and evaluation of targeted interventions, including model emergency preparedness planning for high-rise occupancies.
Prevalence and public health relevance of micronutrient deficiencies and undernutrition in pre-school children and women of reproductive age in Côte d'Ivoire, West Africa
Authors: Rohner Fabian , Northrop-Clewes Christine , Tschannen Andres B , Bosso Patrice E , Kouassi-Gohou Valérie , Erhardt Juergen G , Bui Mai , Zimmermann Michael B , Mascie-Taylor CG Nicholas 
Published: September 2013

AbstractObjectiveTo provide nationally representative data on the prevalence of anaemia, vitamin A and Fe deficiencies among pre-school age children (pre-SAC) and non-pregnant women of reproductive age (WRA), and on vitamin B12and folate deficiencies in WRA, and the influence of inflammation on their interpretation.DesignA cross-sectional survey to measure anthropometry, malaria parasitaemia and micronutrient status. Specifically, blood samples were analysed for Hb, plasma ferritin, soluble transferrin receptors, C-reactive protein, α1-acid glycoprotein, retinol-binding protein, vitamin B12and folate.SettingCôte d'Ivoire in 2007.SubjectsNine hundred and twenty-eight WRA and 879 pre-SAC.ResultsIn WRA, prevalence ofPlasmodiumparasitaemia (5 %) was low, but inflammation (34 %) was higher. Anaemia was a severe public health problem and prevalence differed by residency and eco-region. Inflammation-adjusted Fe deficiency was highest in urban areas (20 %). Nationally, folate deficiency was 86 %, higher in urban areas and varied by eco-region. Prevalence of vitamin B12deficiency was low but higher in the rural areas and the north. Inflammation-adjusted vitamin A deficiency was very low (1 %). In pre-SAC, prevalence of inflammation (67 %) andPlasmodiumparasites (25 %) was high; the latter was associated with poverty, rural residency and higher ferritin concentrations. Anaemia was classified as a severe public health problem (72 %), and was higher in rural areas (76 %) and the north (87 %). A quarter of pre-SAC suffered from vitamin A deficiency (inflammation-adjusted) and prevalence of undernutrition was high.ConclusionsPrevalence of inflammation,Plasmodiumparasitaemia and micronutrient deficiencies were high in Côte d'Ivoire, particularly in pre-SAC. Nutritional interventions should be accompanied by strategies to reduce exposure to infections.
Risk factors for childhood overweight: a 30-month longitudinal study of 3- to 6-year-old children
Authors: De Coen Valerie , De Bourdeaudhuij Ilse , Verbestel Vera , Maes Lea , Vereecken Carine 
Published: September 2013

AbstractObjectiveThe increasing prevalence of childhood overweight is an important health issue. There is a need for longitudinal research among children in order to identify risk factors for childhood overweight. The objective of the present research was to identify potential sociodemographic and behavioural risk factors for development of childhood overweight among 3- to 6-year-old children.DesignLongitudinal study.SettingSixteen pre-primary and primary schools.SubjectsBMI Z-scores at baseline and two follow-up measurements were calculated for 568 children. Sociodemographic, parental adiposity, familial composition, child's diet, physical activity and sedentary behavioural data were collected through questionnaires.ResultsSeveral risk factors for the development of childhood overweight were found. Being an only child, lower maternal educational level, maternal and paternal overweight, more than 1 h screen time on weekdays and high soft drinks consumption were shown to be positively associated with the development of childhood overweight.ConclusionsAlthough behavioural factors are important, our findings support the thesis that interventions on the prevention of childhood overweight should focus on high-risk groups, i.e. children from low socio-economic background or with high parental BMI. Interventions should address the whole family and take into account their lifestyle and structure.
Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion
Authors: Agrawal Alka , Roué Mélanie , Spitzfaden Claus , Petrella Stéphanie , Aubry Alexandra , Hann Michael , Bax Benjamin , Mayer Claudine 
Published: September 2013

DNA gyrase, a type II topoisomerase, regulates DNA topology by creating a double-stranded break in one DNA duplex and transporting another DNA duplex [T-DNA (transported DNA)] through this break. The ATPase domains dimerize, in the presence of ATP, to trap the T-DNA segment. Hydrolysis of only one of the two ATPs, and release of the resulting Pi, is ratelimiting in DNA strand passage. A long unresolved puzzle is how the non-hydrolysable ATP analogue AMP-PNP (adenosine 5′-[β,γ-imido]triphosphate) can catalyse one round of DNA strand passage without Pi release. In the present paper we discuss two crystal structures of the Mycobacterium tuberculosis DNA gyrase ATPase domain: one complexed with AMP-PCP (adenosine 5′-[β,γ-methylene]triphosphate) was unexpectedly monomeric, the other, an AMP-PNP complex, crystallized as a dimer. In the AMP-PNP structure, the unprotonated nitrogen (P-N=P imino) accepts hydrogen bonds from a well-ordered ‘ATP lid’, which is known to be required for dimerization. The equivalent CH2 group, in AMP-PCP, cannot accept hydrogen bonds, leaving the ‘ATP lid’ region disordered. Further analysis suggested that AMP-PNP can be converted from the imino (P-N=P) form into the imido form (P-NH-P) during the catalytic cycle. A main-chain NH is proposed to move to either protonate AMP-P-N=P to AMP-P-NH-P, or to protonate ATP to initiate ATP hydrolysis. This suggests a novel dissociative mechanism for ATP hydrolysis that could be applicable not only to GHKL phosphotransferases, but also to unrelated ATPases and GTPases such as Ras. On the basis of the domain orientation in our AMP-PCP structure we propose a mechanochemical scheme to explain how ATP hydrolysis is coupled to domain motion.
Input Subsidies, Cash Constraints, and Timing of Input Supply
Authors: Holden Stein T. , Lunduka Rodney W. 
Published: September 2013

AbstractIs low input use by poor, smallholder farmers caused by time‐inconsistent behavior or by limited ability to buy inputs? Are input subsidies the best solution to stimulate input demand or are there smarter solutions? These issues are investigated by combining survey data, stated preference questions, and randomized experiments in Malawi. The demand for fertilizer at harvest time and at planting time, farm gate shadow prices for fertilizer, and the gap between the willingness‐to‐accept (WTA) and willingness‐to‐pay (WTP) prices for a standard input package were investigated. Significant effects of timing and of cash constraints were found, suggesting the possibility that smarter designs exist, such as distribution of smaller packages from harvest time to planting time.
Explicet: graphical user interface software for metadata-driven management, analysis and visualization of microbiome data
Authors: Robertson Charles E. , Harris J. Kirk , Wagner Brandie D. , Granger David , Browne Kathy , Tatem Beth , Feazel Leah M. , Park Kristin , Pace Norman R. , Frank Daniel N. 
Published: September 2013

Abstract
Summary: Studies of the human microbiome, and microbial community ecology in general, have blossomed of late and are now a burgeoning source of exciting research findings. Along with the advent of next-generation sequencing platforms, which have dramatically increased the scope of microbiome-related projects, several high-performance sequence analysis pipelines (e.g. QIIME, MOTHUR, VAMPS) are now available to investigators for microbiome analysis. The subject of our manuscript, the graphical user interface-based Explicet software package, fills a previously unmet need for a robust, yet intuitive means of integrating the outputs of the software pipelines with user-specified metadata and then visualizing the combined data.
Availability and Implementation: Explicet is implemented in C++ via the Qt framework and supported in native code on all major operating systems (Windows, Macintosh, Linux). The source code, documents and tutorials are freely available under an open-source license at www.explicet.org.
Contact: daniel.frank@ucdenver.edu
Pulmonary function
Authors: Nixon Patricia
                A. 
Published: September 2013

Abstract
The focus of this chapter is the assessment and interpretation of pulmonary function during exercise in children, with emphasis on the parameters commonly measured in the paediatric setting. The measurements of resting pulmonary function (i.e. lung volumes and expiratory flow rates) are presented to provide the basic foundation for understanding changes that occur with exercise. Some measurements are more relevant to children with cardiopulmonary disorders, and examples of normal and abnormal responses are provided. In some instances, data on children are lacking, so responses of adults are presented.
Physical activity
Authors: Corder Kirsten , Ekelund Ulf 
Published: September 2013

Abstract
Chapter 10 discusses the assessment and interpretation of physical activity in young people in three main sections. The first section is an introduction to why we need to measure physical activity more accurately with definitions of various terminologies commonly used in the field of physical activity research. It then moves on to describe methods used to measure habitual physical activity in children and adolescents, summarizing advantages and limitations of each. The last section discusses the issues surrounding the interpretation of physical activity data in young people.
Pulmonary function
Authors: Fawkner Samantha
                G. 
Published: September 2013

Abstract
Chapter 18 describes important developmental changes in pulmonary structure and function that contribute to changes in the ventilatory response to exercise during growth, describes age and sex differences in the ventilatory response to exercise, provides insights into the developmental aspects of the control of exercise hyperpnoea, explores current issues regarding the ventilatory response to exercise in children, and discusses the potential for training adaptations of pulmonary function during growth.