bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic implementation of cardiopulmonary ultrasound imaging to optimize management of acute decompensated heart failure
Authors: Samir Ahmad , Yosry Doaa , Elgengehe Ahmed Talaat , Said Kareem 
Published: August 2024

Abstract
Background
Heart failure (HF) poses a major health problem, where frequent HF rehospitalizations (HFH) heavily burden national health systems. HFH are predominantly linked to inadequate decongestion before discharge. It is uncertain if systematic implementation of cardio-pulmonary ultra-sound imaging (CPUSI) to standard HF management can improve outcomes and reduce HFH.

Results
This study recruited 50 patients admitted with acute decompensated heart failure (ADHF). Besides the conventional daily assessment, CPUSI was systematically performed to guide treatment decisions, focusing on ventricular filling pressure and 8-zone lung ultrasound (LUS) score. On-admission and predischarge LUS scores were correlated to clinical outcomes. The mean age of the study group was 55.7 ± 10.59 years, with predominance of male gender. Supplementing clinical judgment, CPUSI modified therapeutic strategy in 57 out of 241 assessments (24%), improving patients’ care. Besides its value in guiding therapeutic decisions, the LUS score on admission had a significant positive correlation to the length of ICU stay and the total hospitalization length. Also, LUS score > 12 at discharge predicted 90-day HFH with sensitivity and specificity of 100% and 98%, respectively.

Conclusions
Systematic CPUSI can improve HF management by complementing the often challenging judgment of pulmonary congestion. Adding periodic evaluation of ventricular filling pressures and LUS scores to clinical assessment can optimize treatment decisions and improve patient care. LUS score was a significant predictor for in-hospital and post-discharge clinical outcomes.

Graphical abstract
Generalized lymphadenopathy as an initial presentation of systemic lupus erythematosus: case report and review of the literature
Authors: Ekpenyong Henry Jacob , Olaosebikan Hakeem Babatunde , Aliyu Hassana Hindatu , Babatunde Emmanuel Oladayo , Adelowo Olufemi Oladipo 
Published: August 2024

Abstract
Background
Systemic lupus erythematosus (SLE) is a chronic multisystemic autoimmune disorder with a wide array of clinical manifestations. Lymphadenopathy is occasionally observed in patients with SLE, and although it is sometimes a feature of active disease, it is rarely the initial presenting feature at the time of diagnosis.

Case presentation
We report the case of a 35-year-old woman with clinical features of generalized lymphadenopathy, fatigue, fever, and malaise of approximately 3 months duration with no other constitutional disorders or systemic involvement suggestive of SLE.
Despite extensive laboratory, radiological, and histological evaluations for malignancies and infectious causes of generalized lymphadenopathy, all results returned normal. About a month later, she developed inflammatory polyarthritis, with a markedly elevated erythrocyte sedimentation rate (ESR) of 120 mm/h, and a subsequent serologic workup confirmed the diagnosis of SLE.
Autoimmune serology testing revealed positive results for various antibodies, including antinuclear antibody (ANA) at a titre of 1:5120, homogenous and speckled pattern, anti-Sm, anti-dsDNA, U1-snRNP, Ku, SSA-AntiRo, SSB-AntiLa, anti-SM/RNP, anti-Histone, ribosomal-p protein, and anti-nucleosome antibodies. The diagnosis of SLE was established using the 2019 European League Against Rheumatism/American College of Rheumatology (EULAR/ ACR) criteria.
She was on oral prednisolone, hydroxychloroquine, and calcium/vitamin D3 tablets. The patient improved remarkably, all swollen lymph nodes regressed spontaneously and she had no further need for a hematology review.

Conclusion
While similar cases have been reported in Europe and some parts of Asia, in Africa, a careful search of the literature revealed that such cases have been reported only from Egypt in North Africa and not from other parts of the continent; hence, this case report highlights the importance of recognizing atypical presentations of SLE to improve awareness and diagnosis in different regions.
Clinical, pathologic and molecular findings in 2 Rottweiler littermates with appendicular osteosarcoma
Authors: Silver Kate I. , Mannheimer Joshua D. , Saba Corey , Hendricks William P. D. , Wang Guannan , Day Kenneth , Warrier Manisha , Beck Jessica A. , Mazcko Christina , LeBlanc Amy K. 
Published: August 2024

AbstractAppendicular osteosarcoma was diagnosed and treated in a pair of littermate Rottweiler dogs, resulting in distinctly different clinical outcomes despite similar therapy within the context of a prospective, randomized clinical trial (NCI-COTC021/022). Histopathology, immunohistochemistry, mRNA sequencing, and targeted DNA hotspot sequencing techniques were applied to both dogs’ tumors to define factors that could underpin their differential response to treatment. We describe the comparison of their clinical, histologic and molecular characteristics, as well as those from a companion cohort of Rottweiler dogs. A pan-cancer genomic sequencing panel conducted in the sibling dogs demonstrated both shared and distinct alterations in several genes implicated in osteosarcoma, including CDKN2B, SETD2, MYC, and PDGFRA, while transcriptional profiling of primary tumor tissue indicated under-expression of key immunological response genes. This report provides new insight into molecular features and potential prognostic biomarkers for canine osteosarcoma.
Effects of titration speed, gender, obesity and concomitant medications on the risk and onset time of clozapine-associated fever among Japanese patients with schizophrenia: retrospective review of charts from 21 hospitals
Authors: Kikuchi Yuki , Kurosawa Masahiro , Sakata Mutsumi , Takahashi Yu , Yamamoto Kyohei , Tomita Hiroaki , Yoshio Takashi , Yasui-Furukori Norio 
Published: August 2024

BackgroundClozapine-induced inflammation, such as myocarditis and pneumonia, can occur during initial titration and can be fatal. Fever is often the first sign of severe inflammation, and early detection and prevention are essential. Few studies have investigated the effects of clozapine titration speed and concomitant medication use on the risk of clozapine-induced inflammation.AimsWe evaluated the risk factors for clozapine-associated fever, including titration speed, concomitant medication use, gender and obesity, and their impact on the risk of fever and the fever onset date.MethodWe conducted a case-control study. The medical records of 539 Japanese participants with treatment-resistant schizophrenia at 21 hospitals in Japan who received clozapine for the first time between 2010 and 2022 were retrospectively investigated. Of these, 512 individuals were included in the analysis. Individuals were divided into three groups according to the titration rate recommended by international guidelines for East Asians: the faster titration group, the slower titration group and the ultra-slower titration group. The use of concomitant medications (such as antipsychotics, mood stabilisers, hypnotics and anxiolytics) at clozapine initiation was comprehensively investigated. Logistic regression analysis was performed to identify the explanatory variables for the risk of a fever of 37.5°C or higher lasting at least 2 days.ResultsFever risk significantly increased with faster titration, male gender and concomitant use of valproic acid or quetiapine. No increased fever risk was detected with the use of other concomitant drugs, such as olanzapine, lithium or orexin receptor antagonists. Fever onset occurred significantly earlier with faster titration. Multivariate analysis identified obesity as being a factor that accelerated fever onset.ConclusionA faster titration speed and concomitant treatment with valproic acid and quetiapine at clozapine initiation increased the risk of clozapine-associated fever. Clinicians should titrate clozapine with caution and consider both the titration speed and concomitant medications.
Influence of anti-ferromagnetic ordering and electron correlation on the electronic structure of MnTiO3
Authors: Ali Asif , Maurya R. K. , Bansal Sakshi , Reddy B. H. , Singh Ravi Shankar 
Published: August 2024

Abstract
Electron correlation and long-range magnetic ordering have a significant impact on the electronic structure and physical properties of solids. Here, we investigate the electronic structure of ilmenite MnTiO3 using room temperature photoemission spectroscopy and theoretical approaches within density functional theory (DFT), DFT+ U and DFT+dynamical mean-field theory (DMFT). Mn 2p (Ti 2p) core level photoemission spectra, confirming Mn2+ (Ti4+) oxidation state, exhibit multiple satellites which are very similar to that of MnO (TiO2), suggesting similar strength of various interactions in this system. Valence band spectra collected at different photon energies suggest dominant Mn 3d character in the highest occupied band with a wide insulating gap. DFT(+ U) correctly predicts the experimentally observed anti-ferromagnetic (AFM) insulating ground state for MnTiO3 where the requirement of a large U to reproduce the experimental values of magnetic moment and band gap signifies the importance of electron correlation. Magnetically disordered paramagnetic (PM) phase could be well captured within DFT+DMFT, which provides an excellent agreement for the experimental band gap, paramagnetic moment, valence band spectra as well as dominant Mn 3d character in the highest occupied band. The calculated spectral function remains largely unaffected and exhibits sharper features in the magnetically ordered AFM phase. We show that the electronic structure of MnTiO3 in both the PM and AFM phases can be accurately described within DFT+DMFT.
Neurosarcoidosis With Panhypopituitarism: Two Cases and Literature Review
Authors: Niedzialkowska Ewelina , Blazin Tatjana , Shelden Daniel , Buras Eric D 
Published: August 2024

Abstract
Neurosarcoidosis (NS) with hypothalamic-pituitary (HP) involvement (HP-NS) is a rare clinical condition, conferring variable hormonal deficits that are typically irreversible. Here, we present 2 cases of NS with panhypopituitarism. The first patient presented with cauda equina syndrome and arginine vasopressin deficiency, while the second developed recurrent optic neuritis and vision loss in the setting of a sellar mass. In the first case, neurological symptoms resolved after therapy with high-dose glucocorticoids, infliximab, and methotrexate; while in the second, visual restoration followed resection of the granulomatous tissue and immunosuppressive therapy. In both cases, pituitary dysfunction persisted despite neurological improvement. We contextualized the presentations and outcomes through a literature review of HP-NS case reports and case series. This revealed high rates of extraneurologic sarcoidosis in HP-NS patients with panhypopituitarism, while underscoring the need for hormonal replacement—as endocrinopathies rarely respond to sarcoidosis-directed immunosuppression.
Jiang Qing, the Iconic Anti-icon: Visual Dissection of Female Political Power in Post-Mao People's Republic of China
Authors: Pozzi Laura , Mandzunowski Damian 
Published: August 2024

Abstract
This article examines how, in the years following the end of the Cultural Revolution (1966–76), Jiang Qing 江青 (1914–91) became a negative icon of a liberated woman in high office in the People’s Republic of China (PRC). During the Cultural Revolution, Jiang Qing transformed herself into a model female political leader. After her arrest in 1976, however, political caricatures systematically deconstructed her curated image by transforming her into the antithesis of the ideal powerful woman in a socialist society. Since a model liberated female politician was not yet available, Jiang Qing served as an “iconic anti-iconic” of women in politics under state socialism. Acknowledging the importance of Jiang Qing as a historical figure in Maoist China, this article analyzes how post–Cultural Revolution caricatures of her provide us with an understanding of the Chinese Communist Party’s anxieties about women in power, and it raises questions about the absence of an iconic woman-leader in the PRC’ s political visual culture despite years of campaigning to achieve women’s liberation.
Lower-limb coordination changes following a 6-week training intervention that elicited enhancements to maximum velocity sprint performance
Authors: Lenthall Daniel , Brazil Adam , Castaño-Zambudio Adrián , Lightfoot Harry , Mendiguchia Jurdan , Jiménez-Reyes Pedro , Colyer Steffi L. 
Published: August 2024

ABSTRACT
Alterations to intra- and inter-limb coordination with improved maximal velocity performance remain largely unexplored. This study quantified within-day variability in lower-limb segmental coordination profiles during maximal velocity sprinting and investigated the modifications to coordination strategies in 15 recreationally active males following a 6-week period comprised of a multimodal training programme [intervention group (INT); n=7] or continued participation in sports (control group; n=8). The INT demonstrated a large decrease (effect size=−1.54) in within-day coordination profile variability, suggesting potential skill development. Thigh-thigh coordination modifications for the INT were characterised by an earlier onset of trail thigh reversal in early swing (26 versus 28% stride) and lead thigh reversal in late swing (76 versus 79% stride), rather than increases in overall time spent in anti-phase. Moreover, an increase in backward rotation of thigh relative to shank (effect size, 95% CIs: 0.75, 0.17 to 1.33) and shank relative to foot (0.76, −0.17 to 1.68) during late swing likely facilitated more aggressive acceleration of the limb, contributing to reduced touchdown distance and more favourable lower-limb configuration at initial ground contact. These novel findings provide empirical support for the role of longitudinal coordination modifications in improving maximal velocity performance.
The highly metastatic 4T1 breast carcinoma model possesses features of a hybrid epithelial/mesenchymal phenotype
Authors: Herndon Mary E. , Ayers Mitchell , Gibson-Corley Katherine N. , Wendt Michael K. , Wallrath Lori L. , Henry Michael D. , Stipp Christopher S. 
Published: August 2024

ABSTRACT
Epithelial-mesenchymal transitions (EMTs) are thought to promote metastasis via downregulation of E-cadherin (also known as Cdh1) and upregulation of mesenchymal markers such as N-cadherin (Cdh2) and vimentin (Vim). Contrary to this, E-cadherin is retained in many invasive carcinomas and promotes collective cell invasion. To investigate how E-cadherin regulates metastasis, we examined the highly metastatic, E-cadherin-positive murine 4T1 breast cancer model, together with the less metastatic, 4T1-related cell lines 4T07, 168FARN and 67NR. We found that 4T1 cells display a hybrid epithelial/mesenchymal phenotype with co-expression of epithelial and mesenchymal markers, whereas 4T07, 168FARN, and 67NR cells display progressively more mesenchymal phenotypes in vitro that relate inversely to their metastatic capacity in vivo. Using RNA interference and constitutive expression, we demonstrate that the expression level of E-cadherin does not determine 4T1 or 4T07 cell metastatic capacity in mice. Mechanistically, 4T1 cells possess highly dynamic, unstable cell-cell junctions and can undergo collective invasion without E-cadherin downregulation. However, 4T1 orthotopic tumors in vivo also contain subregions of EMT-like loss of E-cadherin. Thus, 4T1 cells function as a model for carcinomas with a hybrid epithelial/mesenchymal phenotype that promotes invasion and metastasis.
Gain-switched pulse generation of 5.3 ps from 30 GHz-modulation-bandwidth 1270 nm DFB laser diode: erratum
Authors: Kobayashi Masataka , Nakamura Takahiro , Nakamae Hidekazu , Kim Changsu , Akiyama Hidefumi 
Published: August 2024

We present an erratum to our Letter [Opt. Lett. 48, 6344 (2023)10.1364/OL.510237]. This erratum corrects the error of Figs. 3(b) and 4(b) made via incorrect scaling in the horizontal axes. The corrections have no influence on the main text and conclusions of the original Letter.
Hot topic: Mapping of the human intranasal mucosal thermal sensitivity: A clinical study on thermal threshold and trigeminal receptors
Authors: Weise Susanne , Hanslik Pauline , Mignot Coralie , Glushkov Evgenii , Bertsch Arnaud , Dubreuil Romain , Bensafi Moustafa , Fuessel Susanne , Hummel Thomas 
Published: August 2024

Introduction
The olfactory and trigeminal system are closely interlinked. Existing literature has primarily focused on characterizing trigeminal stimulation through mechanical and chemical stimulation, neglecting thermal stimulation thus far. The present study aimed to characterize the intranasal sensitivity to heat and the expression of trigeminal receptors (transient receptor potential channels, TRP).

Methods
A total of 20 healthy participants (aged 21–27 years, 11 women) were screened for olfactory function and trigeminal sensitivity using several tests. Under endoscopic control, a thermal stimulator was placed in 7 intranasal locations: anterior septum, lateral vestibulum, interior nose tip, lower turbinate, middle septum, middle turbinate, and olfactory cleft to determine the thermal threshold. Nasal swabs were obtained in 3 different locations (anterior septum, middle turbinate, olfactory cleft) to analyze the expression of trigeminal receptors TRP: TRPV1, TRPV3, TRPA1, TRPM8.

Results
The thermal threshold differed between locations (p = 0.018), with a trend for a higher threshold at the anterior septum (p = 0.092). There were no differences in quantitative receptor expression (p = 0.46) at the different sites. The highest overall receptor RNA expression was detected for TRPV1 over all sites (p<0.001). The expression of TRPV3 was highest at the anterior septum compared to the middle turbinate or the olfactory cleft. The thermal sensitivity correlated with olfactory sensitivity and results from tests were related to trigeminal function like intensity ratings of ammonium, a questionnaire regarding trigeminal function, nasal patency, and CO2 thresholds. However, no correlation was found between receptor expression and psychophysical measures of trigeminal function.

Discussion
This study provided the first insights about intranasal thermal sensitivity and suggested the presence of topographical differences in thermal thresholds. There was no correlation between thermal sensitivity and trigeminal mRNA receptor expression. However, thermal sensitivity was found to be associated with psychophysical measures of trigeminal and olfactory function.
Muddying the Pioneer Past-Present
Authors: Brandley ben , Stanley Liahnna 
Published: August 2024

Abstract
This essay explores how rhetorics of whiteness and settler colonialism operate within tours performed at two official Church Historic Sites—The Mormon Battalion Center and the Mormon Trails Center. Using settler colonialism as a theoretical framework, we offer three examples of how tours given at these sites reify settler colonial logics including object representations of family relationalities, the trading of a woven basket, and an interactive narrated map detailing U.S.-Mormon government and war policies. We present a critical case for how the Church does not just merely erase nor downplay memory, but that white Mormons materially and systematically shape memory by reconfiguring Indigeneity and reorganizing colonial pasts, a rhetorical strategy which recasts Indigenous land and Black bodies as property in order to secure white Mormonism and settler colonial development. To conclude, we make two suggestions for intersectional points of engagement from which we can challenge Indigenous erasure in communication.
An overview of the production and use of Bacillus thuringiensis toxin
Authors: Li Kaixiao , Chen Mingzhu , Shi Jingyi , Mao Tian 
Published: August 2024

Abstract
The widespread utilization of traditional chemical pesticides has given rise to numerous negative impacts, leading to a surge in interest in exploring environmentally friendly alternatives. Bacillus thuringiensis (Bt), a bacterium renowned for its insecticidal properties, produces Cry proteins during its lifecycle. These proteins have distinct advantages over traditional chemical pesticides, including higher environmental safety, broader insecticidal spectra, and lower pesticide residues. Consequently, the discovery and application of Bt hold immense significance in plant disease and pest management, as well as in plant protection. Currently, Bt preparations occupy a prominent position as the world’s largest and most widely used biopesticides. This article comprehensively reviews the fundamental aspects, insecticidal mechanisms, practical applications, and fermentation technologies related to Bt.
Biosynthesis of Ag/Cu nanocomposite mediated by Curcuma longa: Evaluation of its antibacterial properties against oral pathogens
Authors: Yan Huanfang , Wang Li , Mu Yanfei 
Published: August 2024

Abstract

Curcuma longa is a popular plant around the world with various applications in food and medicinal aspects. An investigation has been conducted on the formulation of Ag/Cu nanocomposite by C. longa as a natural stabilizing agent, without the use of any toxic or harmful reagents. This bio-inspired approach is focused on applicative, facile, and green chemical research. The study also explored the potential of Ag/Cu nanocomposite to prevent dental bacteria growth and prevent adherence in vitro. The biomediated Ag/Cu@ turmeric NCs were characterized by advanced physicochemical techniques. The FE-SEM imaging has established that Ag/Cu@ turmeric has a semi-spherical shape (60.92 nm). The crystallinity of nanocomposite has been confirmed by the XRD technique. Subsequently, the biological activity of the Ag/Cu nanocomposite functionalized with biomolecules was examined. The concentration of 1,000 µg/mL showed the most effective minimum inhibitory concentrations (MICs) against Porphyromonas gingivalis and Streptococcus mutans (MIC  =  16 µg/mL) during the investigation. The addition of Ag/Cu nanocomposite (MIC  =  32 µg/mL) significantly hindered the S. mutans in vitro adherence. According to the findings of this research, Ag/Cu nanocomposite could potentially serve as an effective oral hygiene agent for managing periodontopathic and dental caries conditions.
Energy cost prediction for chromium removal by nanofiltration membrane
Authors: Fadhil Sufyan 
Published: August 2024

Abstract
This paper aims to investigate the energy cost of eliminating Cr(VI) by nanofiltration membranes (NF). The modified pore flow model was utilized to predict the performance of NF membrane in terms of ion retention and water productivity. Then, the energy cost was estimated according to the obtained results from this model as well as available data from literature. The effect of feed flow, applied pressure, and temperature on energy cost were highlighted and thoroughly assessed. It is shown that high retention values can be achieved with relatively high energy cost. Nonetheless, energy cost of 0.04 $/m3 have been estimated for Cr retention less than 95 % at a pressure of 5 bar. It is also assessed that feed flow has a significant influence on energy cost relative to other operating parameters. In particular, increasing feed flow from 40 to 760 L/h leading the energy cost to be increased by twelve times. At high feed flow, however, energy cost can be largely reduced by applying pressure higher than 10 bar. It is concluded that high feed temperature is favored if there is no need for heating equipment.