bluuebunny/crossref_metadata_2025_split huggingface dataset:
A simple nomogram for predicting the mortality of PICU patients with sepsis-associated encephalopathy: a multicenter retrospective study
Authors: Wang Guan , Gao Yan , Fu Yanan , Huo Qin , Guo Enyu , Jiang Qin , Liu Jing , Jiang Xinzhu , Liu Xinjie 
Published: July 2024

BackgroundAs one of the serious complications of sepsis in children, sepsis-associated encephalopathy (SAE) is associated with significantly poor prognosis and increased mortality. However, predictors of outcomes for pediatric SAE patients have yet to be identified. The aim of this study was to develop nomograms to predict the 14-day and 90-day mortality of children with SAE, providing early warning to take effective measures to improve prognosis and reduce mortality.MethodsIn this multicenter, retrospective study, we screened 291 patients with SAE admitted to the PICU between January 2017 and September 2022 in Shandong Province. A least absolute shrinkage and selector operation (LASSO) method was used to identify the optimal prognostic factors predicting the outcomes in pediatric patients with SAE. Then, multivariable logistic regression analysis was performed based on these variables, and two nomograms were built for visualization. We used the area under the curve (AUC), calibration curves and decision curves to test the accuracy and discrimination of the nomograms in predicting outcomes.ResultsThere were 129 patients with SAE in the training cohort, and there were 103 and 59 patients in the two independent validation cohorts, respectively. Vasopressor use, procalcitonin (PCT), lactate and pediatric critical illness score (PCIS) were independent predictive factors for 14-day mortality, and vasopressor use, PCT, lactate, PCIS and albumin were independent predictive factors for 90-day mortality. Based on the variables, we generated two nomograms for the early identification of 14-day mortality (AUC 0.853, 95% CI 0.787–0.919, sensitivity 72.4%, specificity 84.5%) and 90-day mortality (AUC 0.857, 95% CI 0.792–0.923, sensitivity 72.3%, specificity 90.6%), respectively. The calibration plots for nomograms showed excellent agreement of mortality probabilities between the observed and predicted values in both training and validation cohorts. Decision curve analyses (DCA) indicated that nomograms conferred high clinical net benefit.ConclusionThe nomograms in this study revealed optimal prognostic factors for the mortality of pediatric patients with SAE, and individualized quantitative risk evaluation by the models would be practical for treatment management.
Causal association of dietary factors with five common cancers: univariate and multivariate Mendelian randomization studies
Authors: Yang Lin , Wang Li , Bao Erhao , Wang Jiahao , Zhu Pingyu 
Published: July 2024

BackgroundDaily dietary habits are closely related to human health, and long-term unhealthy dietary intake, such as excessive consumption of alcohol and pickled foods, may promote the development of cancers. However, comprehensive research on the causal relationship between dietary habits and cancer is lacking. Therefore, this study aimed to reveal the potential causal link between dietary risk factors and the prognosis of cancer-related to genetic susceptibility.MethodsGWAS (Genome-Wide Association Studies) summary data on dietary habits and five common types of cancer and their pathological subtypes were obtained from the UK Biobank and various cancer association consortia. A univariable two-sample Mendelian randomization (UVMR) and FDR correction analysis was conducted to explore the causal relationships between 45 dietary habits and five common types of cancer and their histopathological subtypes. In addition, multivariable Mendelian randomization analysis (MVMR) was performed to adjust for traditional risk factors for dietary habits, and the direct or indirect effects of diet on cancer were evaluated. Finally, the prognostic impact of selected instrumental variables on cancer was analyzed using an online data platform.ResultsIn the UVMR analysis, four dietary habits were identified as risk factors for cancer, while five dietary habits were identified as protective factors. Among the latter, one dietary habit showed a significant association with cancer even after FDR correction, indicating a potential causal relationship. The MVMR analysis revealed that weekly beer and cider intake, may act as an independent risk factor for cancer development. Other causal associations between dietary habits and cancer risk may be mediated by intermediate factors. In the prognostic analysis, the SNPs (Single Nucleotide Polymorphisms) of average weekly beer and cider intake were set as independent risk factors and were found to significantly impact overall survival (OS) and cancer-specific survival (CSS) in lung cancer.ConclusionThis causal relationship study supports the notion that adjusting daily dietary habits and specific dietary interventions may decrease the risk of cancer.
Effect of lateral septum vasopressin administration on reward system neurochemistry and amphetamine-induced addictive-like behaviors in female rats
Authors: Gárate-Pérez Macarena Francisca , Cáceres-Vergara Daniela , Tobar Francisca , Bahamondes Carolina , Bahamonde Tamara , Sanhueza Claudia , Guzmán Fanny , Sotomayor-Zárate Ramón , Renard Georgina M. 
Published: July 2024

Introduction: The chronic use of psychostimulants increases the risk of addiction and, there is no specific pharmacologic treatment for psychostimulant addiction. The vasopressin (AVP) system is a possible pharmacological target in drug addiction. Previous results obtained in our laboratory showed that amphetamine (AMPH) treatment decreases lateral septum (LS) AVP levels in male rats, and AVP microinjection in LS decreases addictive-like behavior. The aim of the present work was to investigate the effect of AMPH treatment on LS AVP levels and the effect of LS AVP administration on the expression of AMPH-conditioned place preference (CPP) in female rats. The secondary objectives were to study the effect of LS AVP administration on LS GABA and glutamate release in male and female rats and on nucleus accumbens (NAc) dopamine (DA) release in female rats.Methods: Female rats were conditioned with AMPH (1.5 mg/kg i.p.) or saline for 4 days.Results: Conditioning with AMPH did not change LS AVP content in females. However, AVP microinjection into the LS decreased the expression of conditioned place preference (CPP) to AMPH. Glutamate and GABA extracellular levels in the LS induced by AVP were studied in males and females. NAc GABA and DA extracellular levels induced by LS AVP microinjection in female rats were measured by microdialysis. In males, AVP perfusion produced a significant increase in LS GABA extracellular levels; however, a decrease in GABA extracellular levels was observed in females. Both in males and females, LS AVP perfusion did not produce changes in LS glutamate extracellular levels. Microinjection of AVP into the LS did not change GABA or DA extracellular levels in the NAc of females.Discussion: Therefore, AVP administration into the LS produces different LS-NAc neurochemical responses in females than males but decreases CPP to AMPH in both sexes. The behavioral response in males is due to a decrease in NAc DA levels, but in females, it could be due to a preventive increase in NAc DA levels. It is reasonable to postulate that, in females, the decrease in conditioning produced by AVP microinjection is influenced by other factors inherent to sex, and an effect on anxiety cannot be discarded.
Comprehensive analysis of B3 family genes in pearl millet (Pennisetum glaucum) and the negative regulator role of PgRAV-04 in drought tolerance
Authors: Wang Yin-Hua , Ye Xing , Zhao Bi-Yao , Wang Wen-Jing , Zhou Zheng-Feng , Zhang Xiang-Qian , Du Juan , Song Jian-Ling , Huang Xiao-Ling , Ouyang Kun-Xi , Zhong Tian-Xiu , Liao Fei-Xiong 
Published: July 2024

IntroductionMembers of the plant-specific B3 transcription factor superfamily play crucial roles in various plant growth and developmental processes. Despite numerous valuable studies on B3 genes in other species, little is known about the B3 superfamily in pearl millet.Methods and resultsHere, through comparative genomic analysis, we identified 70 B3 proteins in pearl millet and categorized them into four subfamilies based on phylogenetic affiliations: ARF, RAV, LAV, and REM. We also mapped the chromosomal locations of these proteins and analyzed their gene structures, conserved motifs, and gene duplication events, providing new insights into their potential functional interactions. Using transcriptomic sequencing and real-time quantitative PCR, we determined that most PgB3 genes exhibit upregulated expression under drought and high-temperature stresses, indicating their involvement in stress response regulation. To delve deeper into the abiotic stress roles of the B3 family, we focused on a specific gene within the RAV subfamily, PgRAV-04, cloning it and overexpressing it in tobacco. PgRAV-04 overexpression led to increased drought sensitivity in the transgenic plants due to decreased proline levels and peroxidase activity.DiscussionThis study not only adds to the existing body of knowledge on the B3 family’s characteristics but also advances our functional understanding of the PgB3 genes in pearl millet, reinforcing the significance of these factors in stress adaptation mechanisms.
Correlations between non-suicidal self-injury and problematic internet use among Chinese adolescents: a systematic review and meta-analysis
Authors: He Xubin , Yu Qinyao , Peng Jing , Yu Jianghong , Wu Taiying , Qin Yuan , Wang Shengjun , Dong Tiaoxia , Liao Yulong , Hu Chunbi , Yang Ping , Yang Bo 
Published: July 2024

BackgroundNon-Suicidal Self-Injury (NSSI) has continued to be a major issue for public health worldwide, especially among teenagers. Studies have found a certain correlation between NSSI and Problematic Internet Use (PIU). However, this relationship is still unclear among Chinese adolescents, a specific population. Hence, a meta-analysis was carried out on observational studies to explore the connection between NSSI and PIU in Chinese teenagers, aiming to provide more clarity on the correlation.MethodsTo identify the link between NSSI and PIU, we scoured seven digital repositories until November 16, 2023. Employing a random-effects meta-analysis framework, we delved into the association between NSSI and PIU. Additionally, we carried out subgroup evaluations to scrutinize variables including geographical location, age demographics, research methodology, diagnostic instruments, gender, and variables controlled for confounding, like symptoms of depression. For amalgamating data, STATA software (version 16) was deployed.ResultsIn this analysis, we included 15 research papers encompassing a collective sample of 137,166 individuals. Our findings revealed a significant positive association between NSSI and PIU within the adolescent population in China, with an Odds Ratio (OR) of 2.02 and a 95% Confidence Interval (CI) ranging from 1.73 to 2.37. Notably, this correlation was markedly stronger in specific subgroups: adolescents from China’s Western regions exhibited an OR of 4.22 (95% CI: 3.44, 5.18); middle school attendees had an OR of 2.09 (95% CI: 1.92, 2.28); those diagnosed with concurrent depression disorders showed an OR of 2.32 (95% CI: 1.98, 2.73); and female adolescents demonstrated an OR of 2.49 (95% CI: 2.26, 2.75), highlighting the nuanced dynamics of this relationship.ConclusionThis meta-analysis indicates that PIU among adolescents is associated with an increased risk of NSSI. Our findings underscore the importance of targeting specific populations, including those in the western region of China, middle school students, adolescents with comorbid depression disorders, and female adolescents, who may be at higher risk of PIU and subsequently NSSI. These results emphasize the need for tailored interventions and preventive strategies to address these intertwined issues effectively.Systematic review registrationPROSPERO, identifier CRD42024496579.
Toripalimab plus chemotherapy in the treatment of metastatic triple-negative breast cancer: a cost-effectiveness analysis
Authors: Cai Hongfu , Huang Lisheng , Zheng Zhiwei 
Published: July 2024

ObjectiveThis study focuses on assessing the cost-effectiveness of incorporating toripalimab alongside chemotherapy for the treatment of patients diagnosed with metastatic triple-negative breast cancer from the perspective of the Chinese healthcare system.MethodsA partitioned survival model was constructed to simulate the costs and health outcomes over the lifetime of patients with mTNBC. Clinical data regarding overall survival, progression-free survival, and treatment-related adverse events were derived from the TORCHLIGHT clinical trials. Incremental cost-effectiveness ratio (ICER) were calculated based on the gains in quality-adjusted life-year (QALY). The willingness-to-pay (WTP) threshold was defined as $39,855.79 per QALY. Additionally, sensitivity analyses were conducted to examine the robustness of the model.ResultsThe total cost incurred by the group receiving toripalimab was $38,040.62, while the placebo plus chemotherapy was $26,102.07. The utilization of the toripalimab regimen resulted in an increase of 0.74 QALYs and an incremental cost of $11,938.55 compared to the placebo plus chemotherapy group. The ICER was $16,133.18/QALY, indicating that toripalimab plus chemotherapy is a cost-effective strategy according to the WTP threshold. Sensitivity analyses confirmed the robustness of the results.ConclusionThis study suggests that the addition of toripalimab to chemotherapy for the treatment of mTNBC is a cost-effective strategy. The findings provide valuable evidence to guide decision-making regarding treatment selection for patients with mTNBC in China.
Implementing a scoping review to explore sport officials' mental health
Authors: Carter Tori B. , Gorczynski Paul , Coady Christopher J. , Cunningham Ian J. , Mascarenhas Duncan R. D. , Grant Murray , Sullivan Philip , Webb Tom , Livingston Lori A. , Hancock David J. 
Published: July 2024

IntroductionSport officials are tasked with applying rules, maintaining fairness, and ensuring athlete safety. However, sport officials experience anxiety, burnout, and non-accidental violence, with the incidence of these events increasing worldwide. This has led to rising attrition rates among sport officials, with many sport organizations concerned for their operational capacity. The effects of anxiety, burnout, and non-accidental violence might contribute to or be indicative of sport officials' negative mental health outcomes. To develop a clear understanding of how sport officials' mental health is affected by their occupation, it is necessary to identify the mental health outcomes and predictors they experience, and to what extent. The purpose of this scoping review was to identify and examine the empirical research and policy documents surrounding sport officials' mental health.MethodOne thousand, two hundred six articles were identified across four databases: PubMed, Web of Science, SportDiscus, and PsycINFO. Next, a policy search was conducted on the respective international governing body websites from English-speaking countries for the 60 included sports. Following screening, 18 studies and one policy document met the inclusion criteria for exploring sport officials' mental health.ResultsParticipants (N = 7,941) in the studies were mainly European male soccer and basketball referees. Most studies utilized quantitative inquiry (n = 15) rather than qualitative methods (n = 2) or framework development (n = 1). The research demonstrated that sport officials frequently experienced negative mental health outcomes and predictors including anxiety, depression, burnout, lower mental health literacy, and high levels of stigmatization towards mental health.DiscussionThese outcomes were influenced by gender/sex, age, and experience. There is a need to explore personal and environmental (including occupational) factors that cause or contribute to sport officials' mental health symptoms and disorders.
Evolução farmacêutica: implementação em um hospital universitário com a utilização de prontuário eletrônico
Authors: Trindade Marianne Teixeira , Minateli Milene Machado 
Published: July 2024

Objective: The study aimed to build semi-structured models to implement the pharmaceutical evolution in the electronic health records in the pediatrics unit of the University Hospital of the Federal University of Juiz de Fora - Minas Gerais. Methods: The descriptive cross-sectional study was conducted with individuals who were admitted to the non-COVID-19 pediatrics unit from December 01, 2021 to January 31, 2022, and had the pharmacist's clinical activities recorded in their electronic health record. Information was collected from users through the Pharmaceutical History Taking and from the history taking of other professionals, besides the evaluation of prescriptions and recording of interventions suggested by the pharmacist according to the identification of inconsistencies regarding dose, dilutions/diluents, drug interactions, occurrence of adverse reactions, therapeutic duplicity, Y- incompatibilities, and health education. Results: Fourteen semi-structured models based on the SOAP method (Subjective; Objective; Assessment; Plan) were created to implement the pharmaceutical evolution with record standardization. During the study period there were 66 hospitalizations. Of these, 45 were eligible and recorded in the electronic document of the pharmaceutical history taking and the result of the assessment of the daily prescriptions, with or without pharmaceutical interventions. Conclusion: The study showed that the electronic health record provides better continuity of care by the pharmacy team within the pediatric sector and broad access to information, in addition to enriching communication and valuing the service of the clinical pharmacist.
Innovative Development of Enterprises in the Conditions of Sanctions Pressure
Authors: Ахмадеев А.М. 
Published: July 2024

В статье рассмотрены экономические основы инновационного развития предприятий и выделены факторы, которые его обеспечивают. В работе уделяется внимание эффективности становления государственной инновационной политики и указан общественный эффект от внедрения инноваций. Для наглядности проведено сравнение инновационного развития РФ и стран ЕС. Обоснована необходимость привлечения зарубежного опыта инновационных процессов.
The article deals with the economic basis of innovative development of enterprises and highlighted the factors that provide it. The paper focuses on the effectiveness of the formation of the state innovation policy and indicates the social effect of innovation. For visual comparison of innovative development of the Russian Federation and EU countries conducted. The necessity of attracting foreign experience of innovative processes is substantiated.
Innovative Approach to the Organization of Controlling in Terms of Digitalization
Authors: Лабазнова Е.В. , Сердюкова Л.О. , Пахомова А.В. , Баширзаде Р.Р. 
Published: July 2024

В статье рассмотрены основные методологические положения инновационного подхода к организации контроллинга, заключающегося в таких ориентированных на рынок и на клиента функционалах, как планирование, анализ, учет. Отражается переосмысление содержания задач контроллера, состоящее в акцентировании внимания на информационной поддержке процесса контроллинга в условиях цифровой трансформации экономики. Новизна подхода к исследованию контроллинга состоит в том, что авторы рассматривают контроллинг как управленческий сервис, предназначенный для внешних по отношению к подразделению контроллинга пользователей и для функциональных подразделений данного предпринимательства. Предложены рекомендации по созданию системы критериев оценки результатов подразделения контроллинга, на условном примере показано их прикладное значение, состоящее в дифференцированном подходе к оценке показателей, отражающих решение внутренних и внешних задач.
The article deals with the main methodological provisions of the innovative approach to the organization of controlling, which consists in market-oriented and customer-oriented functions such as planning, analysis, accounting. The article reflects the rethinking of the content of the tasks of the controller, which consists in focusing on the information support of the controlling process in the conditions of digital transformation of the economy. The novelty of the approach to the study of controlling is that the authors consider controlling as a management service designed for external, in relation to the controlling unit, users, and for the functional units of this enterprise. Recommendations for the creation of a system of criteria for assessing the results of the controlling unit are proposed, their applied value consisting in a differentiated approach to the assessment of indicators reflecting the solution of internal and external problems is shown on a conditional example.
Motivational Human Resources Management
Authors: Гафарова З.Р. , Гареева З.А. 
Published: July 2024

В статье проведен обзор существующего множества систем стимулирования, результаты анализа используемых в нефтегазодобыче форм мотивационного управления человеческими ресурсами. Раскрывая сущность действующих систем стимулирования, авторы критически рассматривают возможности их использования на предприятиях нефтяной и газовой промышленности. Также в статье отражены результаты использования различных систем стимулирования на предприятиях.
The article reviewed the existing set of incentive systems, the results of the analysis of existing forms of motivational human resource management. Revealing the essence of incentive systems, the authors critically consider the possibilities of their use in the enterprises of the oil and gas industry. The article also reflects the results of using various incentive systems in enterprises.
Project Financing of Housing Construction Using Crowdfunding Technology
Authors: Садыкова А.И. , Курманова Л.Р. 
Published: July 2024

В условиях постепенного перехода от долевого к проектному финансированию жилищного строительства застройщики и банки сталкиваются с проблемой дефицита ресурсов на финансирование всех новостроек и завершение проектов. Механизм проектного финансирования остается не вполне проработанным, что вызывает интерес в рассмотрении иных форм финансирования строительных объектов, в частности, с применением технологии краудфандинга, возможности и преимущества которого рассматриваются в научной статье.
In the context of a gradual transition from equity to project financing of housing construction, developers and banks are faced with the problem of a shortage of resources to finance all new buildings and the completion of projects. The mechanism of project financing remains not fully developed, which causes interest in considering other forms of financing of construction projects, in particular, using the technology of crowdfunding, the possibilities and advantages of which are discussed in a scientific article.
Principles of Development of the Transport and Logistics System of Ufa
Authors: Шайахметов Р.Р. 
Published: July 2024

В статье рассмотрены основные направления развития транспортно-логистической системы города Уфы. Выявлены проблемы, накопленные в данной сфере. Автором установлены тренды пространственного развития Уфимской агломерации. Предложен механизм повышения эффективности общественного транспорта, а также система взаимодействия бизнеса и власти.
The article deals with the main directions of development of transport and logistics system of the city of Ufa. The problems accumulated in this sphere are revealed. The author establishes the trends of spatial development of the Ufa agglomeration. The mechanism of increase of efficiency of public transport, and also system of interaction of business and the power is offered.