bluuebunny/crossref_metadata_2025_split huggingface dataset:
Handel's use of plucked instruments
Authors: Fraga Orlando 
Published: September 2014

Three central features of Baroque music encompass a large portion of questions about the performance of this particular repertory: its improvisatory aspect, the use of basso continuo, and the instrumental color and variety. Teorbo and lute solos, aside of playing a role as a continuo, filled in the intermissions of oratorios in Italy since late 17th century, while organ concertos provided the same function for English oratorios in the early 18th century. It is from Handel's early period ‒ his first trip to Italy in 1707 ‒ that teorbo and archiliuto start to appear in his vocal music. Handel employed either the teorbo or archiliuto (or simply liuto) in twelve vocal works and in one instrumental Ouverture. A complete examination of the circumstances that involve this particular aspect of Handel's music is the subject this paper.
The child as musician: A handbook of musical development – Resenha Descritiva
Authors: Krüger Veridiana , Krüger Igor , Raby Melody , Rosa Anderson , Pscheidt Jean , Gross Elisa 
Published: September 2014

Resenha de The child as musician: A handbook of musical development (New York, Oxford University Press, 2006, 501 páginas) editado por Gary E. McPherson Grupo de Pesquisa PROFCEM/UFPR/CNPq
Diseño de un sistema de evaluación del rendimiento ambiental en corredores de movilidad urbana
Authors: Soria Lara Julio Alberto , Valenzuela Montes Luis Miguel 
Published: September 2014

Durante las últimas décadas ha existido un creciente interés por la dimensión ambiental de la movilidad urbana. De este modo, distintas técnicas de análisis y evaluación (EIA, EAE, Análisis Coste-Beneficio, Análisis del ciclo de vida, etc.) son utilizadas con el fin de reducir las posibles consecuencias ambientales de una intervención sobre la movilidad en nuestras ciudades. A pesar de que estas técnicas están ampliamente extendidas, existen evidencias que cuestionan su utilidad en el campo de la movilidad urbana, tanto por razones de procedimiento y/o forma, como por razones puramente técnicas o de fondo. Se explora aquí la conveniencia de utilizar métodos que pongan énfasis sobre la funcionalidad ambiental de proyectos de movilidad urbana en términos de rendimiento, como vía complementaria al uso de métodos de evaluación más convencionales. Para ello, se diseña y aplica un sistema de evaluación del rendimiento ambiental para corredores de movilidad urbana, incluyendo una aplicación práctica al caso del Área Metropolitana de Granada en España.
Durant les últimes dècades ha existit un creixent interès per la dimensió ambiental de la mobilitat urbana. D’aquesta manera, diferents tècniques d’anàlisi i avaluació (EIA, EAE, Anàlisi Cost-Benefici, Anàlisi del cicle de la vida, etc.) són utilitzades amb la finalitat de reduir les possibles conseqüències ambientals d’una intervenció sobre la mobilitat a les nostres ciutats. Tot i que aquestes tècniques estan àmpliament esteses, existeixen evidències que qüestionen la seva utilitat en el camp de la mobilitat urbana, tant per raons de procediment y/o forma, com per raons purament tècniques o de fons. S’explora aquí la conveniència d’utilitzar mètodes que posin èmfasi sobre la funcionalitat ambiental de projectes de mobilitat urbana en termes de rendiment, com a via complementària a l’ús de mètodes d’avaluació més convencionals. Per això es dissenya i aplica un sistema d’avaluació del rendiment ambiental per corredors de mobilitat urbana, incloent una aplicació pràctica del cas de l’Àrea Metropolitana de Grana a Espanya.
Over the last decades a growing interest regarding the environmental dimension of urban mobility has been experienced. Different environmental assessment techniques (EIA, SEA, Costs-Benefits analysis, vulnerability analysis, etc.) are frequently used to minimize environmental consequences of mobility projects on cities. Despite these techniques are widely extended, certain evidences show problems when confronted with complexity of urban mobility. This seems due to technical and conceptual reasons. The paper aims to gain insight into this problem through the study of evaluation methods orientated towards assessing the environmental performance of urban mobility. To illustrate and assess the worth of this hypothesis, an environmental performance system to assess urban transit corridors has been developed and applied on the real case of a metropolitan transit corridor in Granada (Spain).
Editorial de la Sección Especial
Authors: Pérez Sosa Isacó 
Published: September 2014

Artículo que define los diferentes artículos de la Sección Especial del nº 25 de la Revista ACE.
Article que defineix els articles de la Secció Especial del nº 25 de la Revista ACE.
This article define the contents of the Special Section of Issue nº 25 of the ACE Journal.
Urban intervention on the coastline of Catalunya: a new understanding of tourism
Authors: Roca Blanch Estanislao 
Published: September 2014

El artículo presenta un breve resumen del paralelismo entre el fenómeno del turismo, la legislación de ordenación del territorio y la planificación urbanística municipal en España. En él se establecen los argumentos que han conducido a un cambio de modelo en una nueva era del turismo, aunque éste no haya reemplazado ni eliminado el turismo de masas de la etapa fordista, el cual sigue siendo hegemónico. Se presentan, además, diversos casos ilustrativos de cómo, a través del planeamiento, se han podido reconducir proyecciones agresivas de la urbanización sobre el litoral catalán, apuntando hacia a un cambio cualitativo de los destinos turísticos maduros. Estos casos vienen precedidos por una propuesta sorprendente para proteger un sector de la costa de Tarragona en los años 80.
Aquest article presenta un breu resum del paral·lelisme entre el fenomen del turisme, la legislació d’ordenació del territori i la planificació urbanística municipal a Espanya. En ell s’estableixen els arguments que han conduït a un canvi de model en una nova era del turisme, tot i que aquest no hagi substituït ni eliminat el turisme de masses de l’etapa fordista, el qual segueix essent hegemònic. Es presenten, a més, diversos casos il·lustratius de com, a través del planejament, s’ha pogut reconduir projeccions agressives de la urbanització sobre el litoral català, apuntant cap a un canvi qualitatiu de les destinacions turístiques madures. Aquests casos venen precedits per una proposta sorprenent per a protegir un sector de la costa de Tarragona en els anys 80.
This article presents a brief summary of the relationship between tourism, urban law and municipal planning in Spain. It sets out the arguments which led to a change of model in a new era of tourism, although other forms of tourism have not yet replaced Fordist mass tourism, which remains hegemonic. Furthermore, it exposes several cases which illustrate how territorial planning helped review and amend some harmful provisions for the rampant urbanization of the Catalan coast. This attitude points to a qualitative change of mature vacation spots. These cases are preceded by a presentation of an unusual counter-proposal for the protection of the coastline of Tarragona, carried out at the beginning of the 1980s.
Walgreens Connected Care
Authors: DuChane Janeen , Clark Bobby , Staskon Francis , Miller Rick , Love Kathleen , Duncan Ian 
Published: September 2014

Background: The Walgreens Connected Care Multiple Sclerosis (CCMS) treatment management program provides enhanced levels of monitoring, oversight, and care for patients taking MS disease-modifying agents. This study compared rates of adherence to MS medications for patients participating in the CCMS program for at least 6 months with those for patients participating for less than 6 months. For a subsample of patients, we also examined the relationship between adherence and the presence of fatigue or depression.Methods: This was a retrospective study of patients new to the CCMS program and followed up for 1 year of participation. Adherence to MS medications was measured as the proportion of days covered, with propensity scores used to match the CCMS intervention group to the less-managed comparison group. The impact of program participation on the relationship between depression or fatigue and adherence over time was a separate analysis.Results: Mean proportion of days covered rates improved significantly in the group managed for at least 6 months compared with those who were less managed. Positive screenings for fatigue and depression reduced adherence in the less-managed group but not in patients with longer participation in the program.Conclusions: Overall, the CCMS program significantly increased adherence to MS medications. This improved adherence was not negatively impacted by positive screenings for fatigue and depression.
Patient Preferences for Attributes of Multiple Sclerosis Disease-Modifying Therapies
Authors: Wilson Leslie S. , Loucks Aimee , Gipson Gregory , Zhong Lixian , Bui Christine , Miller Elizabeth , Owen Mary , Pelletier Daniel , Goodin Douglas , Waubant Emmanuelle , McCulloch Charles E. 
Published: September 2014

Background: Timely individualized treatment is essential to improving relapsing-remitting multiple sclerosis (RRMS) patient health outcomes, yet little is known about how patients make treatment decisions. We sought to evaluate RRMS patient preferences for risks and benefits of treatment.
Methods: Fifty patients with RRMS completed conjoint analysis surveys with 16 hypothetical disease-modifying therapy (DMT) medication profiles developed using a fractional factorial design. Medication profiles were assigned preference ratings from 0 (not acceptable) to 10 (most favorable). Medication attributes included a range of benefits, adverse effects, administration routes, and market durations. Analytical models used linear mixed-effects regression.
Results: Participants showed the highest preference for medication profiles that would improve their symptoms (β = 0.81–1.03, P &lt; .001), not a proven DMT outcome. Preventing relapses, the main clinical trial outcome, was not associated with significant preferences (P = .35). Each year of preventing magnetic resonance imaging changes and disease symptom progression showed DMT preferences of 0.17 point (β = 0.17, P = .002) and 0.12 point (β = 0.12, P &lt; .001), respectively. Daily oral administration was preferred over all parenteral routes (P &lt; .001). A 1% increase in death or severe disability decreased relative DMT preference by 1.15 points (P &lt; .001).
Conclusions: Patient preference focused on symptoms and prevention of progression but not on relapse prevention, the proven drug outcome. Patients were willing to accept some level of serious risk for certain types and amounts of benefits, and they strongly preferred daily oral administration over all other options.
A Randomized Placebo-Controlled Trial of Duloxetine for Central Pain in Multiple Sclerosis
Authors: Brown Theodore R. , Slee April 
Published: September 2014

Background: Pain is common in multiple sclerosis (MS). Duloxetine has a potential therapeutic role in treating MS-related pain.
Methods: Thirty-eight MS patients were randomized 1:1 to receive duloxetine (n = 18) or matched placebo (n = 20). The dosing regimen was 30 mg daily for 1 week, then 60 mg daily for 5 weeks. The primary outcome measure was change in worst pain for week 6 relative to baseline recorded on a daily pain diary.
Results: Of 38 randomized patients, 14 (78%) patients randomized to duloxetine and 18 (90%) randomized to placebo completed treatment per protocol. These participants had an average age of 55.5 years, 25% were male, and 66% had relapsing-remitting MS (RRMS). Baseline characteristics were similar. Discontinuations were due primarily to drug intolerance. Among those who completed treatment, worst pain at 6 weeks was reduced by 29% (±20%) for duloxetine versus 12% (±18%) for placebo (P = .016). Average daily pain at 6 weeks was reduced by 39% (±29%) in the duloxetine group compared to 10% (±18.8%) in the placebo group (P = .002). There were no significant changes (week 6 vs. baseline) or between-group differences for subject global impression, Beck Depression Inventory, 36-item Short Form Health Status Survey (SF-36), or sleep quality score.
Conclusions: Fewer patients could tolerate duloxetine compared to placebo. Among patients who completed 6 weeks of treatment, there were significant reductions in average and worst daily pain scores with duloxetine compared to placebo. This study suggests that duloxetine has a direct pain-relieving effect in MS.
No evident association between efavirenz use and suicidality was identified from a disproportionality analysis using the FAERS database
Authors: Napoli Andrew A , Wood Jennifer J , Coumbis John J , Soitkar Amit M , Seekins Daniel W , Tilson Hugh H 
Published: September 2014

ObjectiveTo assess the potential association of selected antiretrovirals (ARVs), including efavirenz, with suicidality.DesignRetrospective analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS), by performing a Multi‐Item Gamma Poisson Shrinker (MGPS) disproportionality analysis.MethodsMGPS disproportionality analysis, a technique to identify associations between drugs and adverse events, was performed using cumulative data from the FAERS database collected up to August 2012. This method yields an Empirical Bayesian Geometric Mean score and corresponding 90% confidence interval (EB05, EB95). EB05 scores ≥2 were pre‐defined as a signal for a potential drug‐event association. The FAERS database includes spontaneous adverse‐event reports from consumers and healthcare professionals. All FAERS reports of suicidality (including suicidal ideation, suicide attempt and completed suicide or a composite of these) in patients taking efavirenz (as single agent or in fixed‐dose combination), atazanavir, darunavir, etravirine, nevirapine and raltegravir were identified. A number of parallel analyses were performed to assess the validity of the methodology: fluoxetine and sertraline, antidepressants with a known association with suicidality, and raltegravir, an ARV with rhabdomyolysis and myopathy listed as “uncommon” events in the US‐prescribing information.ResultsA total of 29,856 adverse event reports were identified among patients receiving efavirenz, atazanavir, darunavir, etravirine, nevirapine and raltegravir, of which 457 were reports of suicidality events. EB05 scores observed for the composite suicidality term for efavirenz (EB05=0.796), and other ARVs (EB05=0.279–0.368), were below the pre‐defined threshold. Fluoxetine and sertraline gave EB05 scores for suicidality >2. Raltegravir gave EB05 scores >2 for myopathy and rhabdomyolysis.ConclusionsThe pre‐determined threshold for signals for suicidality, including suicidal ideation, suicide attempt, completed suicide and a composite suicidality endpoint, was not exceeded for efavirenz and other ARVs in this analysis. Efavirenz has been associated with suicidality in clinical trials. Further studies that adjust for confounding factors are needed to better understand any potential association with ARVs and suicidality.
USDA‐ARS Riesel Watersheds, Riesel, Texas, USA: Water quality research database
Authors: Harmel R. Daren , Haney Richard L. , Smith Douglas R. , White Michael , King Kevin W. 
Published: September 2014

AbstractThe 75 year legacy database including discharge, sediment loss, land management, and meteorological data for the USDA‐ARS Riesel Watersheds, Riesel, TX, USA has been available on the web for more than a decade (www.ars.usda.gov/spa/hydro‐data) and used in numerous studies and publications; however, only recently have these data been added to the Sustaining the Earth's Watersheds, Agricultural Research Data System (STEWARDS) database (www.nrrig.mwa.ars.usda.gov/stewards/stewards.html). In addition, water quality data including dissolved inorganic N and P compounds measured from more than 1000 storm runoff events, 1300 base flow sampling events (lateral subsurface return flow or seepage flow), and 157 precipitation events through 2012 were added. The objectives of this manuscript are to present relevant background information on these data, summarize the data collection and analysis methodology, present the measured data along with cursory analyses, and convey the commitment of the USDA‐ARS Riesel Watersheds to long‐term data accessibility and database enhancement for water quality data and research.
Global dry deposition of nitrogen dioxide and sulfur dioxide inferred from space‐based measurements
Authors: Nowlan C. R. , Martin R. V. , Philip S. , Lamsal L. N. , Krotkov N. A. , Marais E. A. , Wang S. , Zhang Q. 
Published: September 2014

AbstractA method is developed to estimate global NO2 and SO2 dry deposition fluxes at high spatial resolution (0.1°×0.1°) using satellite measurements from the Ozone Monitoring Instrument (OMI) on the Aura satellite, in combination with simulations from the Goddard Earth Observing System chemical transport model (GEOS‐Chem). These global maps for 2005–2007 provide a data set for use in examining global and regional budgets of deposition. In order to properly assess SO2 on a global scale, a method is developed to account for the geospatial character of background offsets in retrieved satellite columns. Globally, annual dry deposition to land estimated from OMI as NO2 contributes 1.5 ± 0.5 Tg of nitrogen and as SO2 contributes 13.7 ± 4.0 Tg of sulfur. Differences between OMI‐inferred NO2 dry deposition fluxes and those of other models and observations vary from excellent agreement to an order of magnitude difference, with OMI typically on the low end of estimates. SO2 dry deposition fluxes compare well with in situ Clear Air Status and Trends Network‐inferred flux over North America (slope = 0.98, r = 0.71). The most significant NO2 dry deposition flux to land per area occurs in the Pearl River Delta, China, at 13.9 kg N ha−1 yr−1, while SO2 dry deposition has a global maximum rate of 72.0 kg S ha−1 yr−1 to the east of Jinan in China's Shandong province. Dry deposition fluxes are explored in several urban areas, where NO2 contributes on average 9–36% and as much as 85% of total NOy dry deposition.
First spaceborne observation of the entire concentric airglow structure caused by tropospheric disturbance
Authors: Akiya Y. , Saito A. , Sakanoi T. , Hozumi Y. , Yamazaki A. , Otsuka Y. , Nishioka M. , Tsugawa T. 
Published: September 2014

AbstractSpaceborne imagers are able to observe the airglow structures with wide field of views regardless of the tropospheric condition that limits the observational time of the ground‐based imagers. Concentric wave structures of the O2 airglow in 762 nm wavelength were observed over North America on 1 June 2013 from the International Space Station. This was the first observation in which the entire image of the structure was captured from space, and its spatial scale size was determined to be 1200 km radius without assumptions. The apparent horizontal wavelength was 80 km, and the amplitude in the intensity was approximately 20% of the background intensity. The propagation velocity of the structure was derived as 125 ± 62 m/s and atmospheric gravity waves were estimated to be generated for 3.5 ± 1.7 h. Concentric structures observed in this event were interpreted to be generated by super cells that caused a tornado in its early phase.
Observations on stratified flow over a bank at low Froude numbers
Authors: Jarosz Ewa , Wijesekera Hemantha W. , Teague William J. , Fribance Diane B. , Moline Mark A. 
Published: September 2014

AbstractIn June 2011, a 9 day oceanographic survey was conducted over the East Flower Garden Bank, a coral reef, located on the outer shelf in the northwestern Gulf of Mexico. Current, temperature, conductivity, and microstructure measurements were collected to characterize flow evolution, turbulence, and mixing over the bank. During the experiment, the flow was highly stratified, subcritical (Froude number below 0.4), hydrostatic, and nonlinear with rotational effects being important. Observations showed that flow structure, turbulence, and mixing were highly dependent on the direction and strength of the current; thus, they varied spatially and temporarily. Responses resulting from interactions between the free‐stream flow and the obstacle were significantly different on the upstream and downstream sides of the bank. Blocking and diverging of the flow just below the bank height was observed on the upstream side. On the downstream side, a wake with imbedded vortices developed. Moreover, turbulence was amplified over the bank top and on its downstream side. Turbulent dissipation rates were as high as 10−6 W kg−1 and resulted in measured rates of energy dissipation and mixing by turbulence per unit width as high as 40 W m−1. Mixing on the downstream side was elevated with eddy diffusivities reaching 10−3 m2 s−1, well above a typical value of 10−5 m2 s−1 commonly found in the ocean thermocline and over shelves with flat topography. On the upstream side, estimated eddy diffusivities were close to that for the ocean thermocline, i.e., they were generally less than 0.5×10−4 m2 s−1.
Uncovering the Stoichiometry of Pyrococcus furiosus RNase P, a Multi‐Subunit Catalytic Ribonucleoprotein Complex, by Surface‐Induced Dissociation and Ion Mobility Mass Spectrometry
Authors: Ma Xin , Lai Lien B. , Lai Stella M. , Tanimoto Akiko , Foster Mark P. , Wysocki Vicki H. , Gopalan Venkat 
Published: September 2014

AbstractWe demonstrate that surface‐induced dissociation (SID) coupled with ion mobility mass spectrometry (IM‐MS) is a powerful tool for determining the stoichiometry of a multi‐subunit ribonucleoprotein (RNP) complex assembled in a solution containing Mg2+. We investigated Pyrococcus furiosus (Pfu) RNase P, an archaeal RNP that catalyzes tRNA 5′ maturation. Previous step‐wise, Mg2+‐dependent reconstitutions of Pfu RNase P with its catalytic RNA subunit and two interacting protein cofactor pairs (RPP21⋅RPP29 and POP5⋅RPP30) revealed functional RNP intermediates en route to the RNase P enzyme, but provided no information on subunit stoichiometry. Our native MS studies with the proteins showed RPP21⋅RPP29 and (POP5⋅RPP30)2 complexes, but indicated a 1:1 composition for all subunits when either one or both protein complexes bind the cognate RNA. These results highlight the utility of SID and IM‐MS in resolving conformational heterogeneity and yielding insights on RNP assembly.
Monitoring the Transition from Spherical to Polymer‐like Surfactant Micelles Using Small‐Angle X‐Ray Scattering
Authors: Jensen Grethe Vestergaard , Lund Reidar , Gummel Jérémie , Narayanan Theyencheri , Pedersen Jan Skov 
Published: September 2014

AbstractDespite over a century of modern surfactant science, the kinetic pathways of morphological transitions in micellar systems are still not well understood. This is mainly as a result of the lack of sufficiently fast methods that can capture the structural changes of such transitions. Herein, a simple surfactant system consisting of sodium dodecyl sulfate (SDS) in aqueous NaCl solutions is investigated. Combining synchrotron radiation small‐angle X‐ray scattering (SAXS) with fast stopped‐flow mixing schemes allows monitoring the process where polymer‐like micelles are formed from globular micelles when the salt concentration is suddenly increased. The results show that “worm‐like” micelles are formed by fusion of globular micelles and short cylinders in a fashion that bears similarities to a step‐like polymerization process.