bluuebunny/crossref_metadata_2025_split huggingface dataset:
Azobenzene switch with a long-lived cis-state to photocontrol the enzyme activity of a histone deacetylase-like amidohydrolase
Authors: Korbus Michael , Balasubramanian Ganesh , Müller-Plathe Florian , Kolmar Harald , Meyer-Almes Franz-Josef 
Published: November 2013

Abstract
The control of enzymes by use of an external stimulus such as light enables the temporal and spatial regulation of defined chemical reactions in a highly precise manner. In this work we investigated and characterized the reversible photocontrol of a bacterial histone deacetylase-like amidohydrolase (HDAH) from Bordetella/Alcaligenes strain FB188, which holds great potential to control deacetylation reactions of a broad spectrum of substrates in biotechnological and biomedical applications. Several HDAH variants with a single surface accessible cysteine close to the active site were developed and covalently modified by a monofunctional azobenzene-based photoswitch [4-phenylazomaleinanil (4-PAM)]. The enzymatic activity of three HDAH variants (M30C, S20C and M150C) were shown to be controlled by light. The thermal cis-to-trans relaxation of azobenzene conjugated to HDAH was up to 50-fold retarded compared to unbound 4-PAM allowing light pulse switching rather than continuing irradiation to maintain the thermodynamically less stable cis-state of covalently attached 4-PAM.
Occupational and Environmental Exposure to Mercury among Iranian Hairdressers
Authors: Fakour Hoda , Esmaili‐Sari Abbas 
Published: November 2013

Occupational and Environmental Exposure to Mercury among Iranian Hairdressers: Hoda FAKOUR, et al. Department of Environment, Faculty of Natural Resources and Marine Sciences, Tarbiat Modares University, Iran—ObjectivesThe aim of this study was to describe the mercury concentrations in female hairdressers associated with occupational and environmental exposure through cosmetic products and amalgam fillings.MethodsSixty‐two hair and nail samples were collected randomly from Iranian hairdressers. Hg level determination was carried out using a LECO, AMA 254, Advanced Mercury Analyzer according to ASTM, standard No. D‐6722.ResultsThe mean mercury levels were 1.15 ± 1.03 µg/g and 1.82 ± 1.12 µg/g in the hair and nail samples, respectively with a positive correlation among them (r=0.98). A significant relation was also observed between Hg levels and the number of amalgam fillings (p<0.001), use of cosmetics (p<0.001), and use of gloves (p=0.02).ConclusionsThe Hg levels in about one‐third of the studied samples were higher than the USEPA‐recommended 1 µg/g, which represents a serious health risk. Hairdressers with continuous use of cosmetics and a high number of amalgam fillings had significantly elevated mercury concentrations in their hair and nails, suggesting the importance of mercury exposure assessment in hidden, less‐explored sources of Hg in the workplace.
The Introduction of a Nurse Practitioner Model of Care Into an Australian Outpatient Setting
Authors: Scanlon Andrew 
Published: November 2013

Introduction: This article aims to examine the role of a nurse practitioner (NP) within a public hospital Department of Neurosurgery outpatient setting in Melbourne Australia. Background: Neurosurgical activity in the outpatient clinic has been increasing. Public health networks around Australia have introduced various initiatives to address the growing concern of timely access for specialized care. One such initiative has been the introduction of NPs in both outpatient and acute care settings.Contemporary practices of an NP working in an Australian neurosurgery department are described. How the role was first proposed initiated, and the training and capacity building is also explored and the national, state, and local structures and processes that have defined the role will be described.
Retroperitoneal fibrosis in feline renal transplant recipients: 29 cases (1998–2011)
Authors: Wormser Chloe , Phillips Heidi , Aronson Lillian R. 
Published: November 2013

Abstract
Objective—To evaluate features, treatment, and prognosis associated with retroperitoneal fibrosis that developed after renal transplantation in cats.
Design—Retrospective case series.
Animals—29 cats.
Procedures—Medical records of cats that developed retroperitoneal fibrosis after renal transplantation at the College of Veterinary Medicine, University of Pennsylvania, between 1998 and 2011 were reviewed for signalment, date of transplantation, age, results of urine and blood analyses, blood pressure at the time of diagnosis, infectious disease and medication anamneses, anesthetic protocols, and intraoperative complications.
Results—Of 138 transplant recipients, 29 (21%) developed clinically important retroperitoneal fibrosis. Nineteen (66%) were male, and median age at the time of renal transplantation was 8 years (range, 4 to 13 years). Median number of days after transplantation to diagnosis of retroperitoneal fibrosis was 62 (range, 4 to 730 days; mean, 125 days). The most common clinical signs were lethargy and anorexia. All affected cats were azotemic (BUN concentration > 32 mg/dL; creatinine concentration > 2.0 mg/dL) and anemic (PCV < 35%) at the time of retroperitoneal fibrosis diagnosis, although cats were nonazotemic at the time of discharge following transplantation, and anemia was less pronounced. Twenty-five cats successfully underwent surgical ureterolysis in which scar tissue was dissected away from the allograft ureter to relieve extraluminal compression. Retroperitoneal fibrosis recurred in 6 (22%) cats a median of 180 days (range, 8 to 343 days) following the original diagnosis and was treated successfully by repeated ureterolysis.
Conclusions and Clinical Relevance—Retroperitoneal fibrosis occurred in a substantial percentage of feline renal transplant recipients and should be considered a differential diagnosis in any feline renal transplant recipient with clinicopathologic findings, imaging abnormalities, or signs suggestive of obstructive uropathy.
Clinical signs, treatment, and prognosis for horses with impaction of the cranial aspect of the base of the cecum: 7 cases (2000–2010)
Authors: Sherlock Ceri E. , Eggleston Randall B. 
Published: November 2013

Abstract
Objective—To determine the clinical signs, treatment, and prognosis for horses with impaction of the cranial aspect of the base of the cecum (cecal cupula).
Design—Retrospective observational case series.
Animals—7 horses with colic attributed to cecal cupula impaction.
Procedures—Medical records were reviewed and horses that underwent exploratory celiotomy from 2000 through 2010 were identified. Horses with cecal cupula impaction and without other abdominal problems to which colic could be attributed were selected for inclusion in the study. Information regarding history, clinical findings, diagnostic testing, surgical findings and treatments, and treatments and complications after surgery was recorded. Rate of survival of horses to discharge from the hospital was determined. Long-term follow-up information was obtained with telephone questionnaires.
Results—Cecal cupula impaction without other cecal abnormalities was identified in 7 horses during exploratory celiotomy. Although clinical signs varied, horses typically had mild signs of colic and nondiagnostic rectal examination findings but were in systemically stable conditions at the time of the initial evaluation. Typhlotomies were performed and impactions were resolved by means of lavage and evacuation. All horses survived to discharge from the hospital and lived ≥ 2 years after surgery.
Conclusions and Clinical Relevance—Results of this study suggested cecal cupula impaction was a novel type of cecal impaction that was uncommon. Impactions did not involve the cecal body or apex and hypertrophy of the cecal wall was not grossly detected. Impactions were successfully treated with typhlotomy, lavage, and evacuation. Horses had a good prognosis after surgical treatment.
Differences in Neuromuscular Control and Quadriceps Morphology Between Potential Copers and Noncopers Following Anterior Cruciate Ligament Injury
Authors: MacLeod Toran D. , Snyder-Mackler Lynn , Buchanan Thomas S. 
Published: November 2013

Study Design Prospective cross-sectional study. Objectives To compare knee muscle morphology and voluntary neuromuscular control in individuals who sustained an anterior cruciate ligament (ACL) injury and were identified as being capable of avoiding surgery (potential copers) and those who were recommended for surgery (noncopers), within 6 months of injury. Background Quadriceps atrophy and poor neuromuscular control have been found in noncopers. However, the reasons why some noncopers may be able to avoid surgery remain elusive. Methods Twenty participants (10 ACL-deficient noncopers and 10 ACL-deficient potential copers) were included in this study. Axial spin-echo, T1-weighted magnetic resonance imaging data of the lower extremities were captured. The volume and maximum cross-sectional area (CSA) of each muscle of the quadriceps and hamstrings were calculated following digital reconstruction. In addition, voluntary neuromuscular control was evaluated using an established target-matching task that required participants to produce static isometric loads across the knee joint. Electromyography was acquired from 5 muscles as participants performed the target-matching task. Circular statistics were used to calculate a specificity index to describe how well focused each muscle was activated toward its primary direction of muscle action. The ACL-deficient limb was then compared to the uninvolved limb of the noncopers and potential copers. Results The vasti (vastus medialis and vastus intermedius) of the involved limb of the noncopers were significantly smaller (P<.031) in comparison to those of their uninvolved limb. The potential copers' vastus lateralis maximum CSA (P = .047), total quadriceps muscle volume (P = .020) and maximum CSA (P = .015), and quadriceps-hamstring ratio volume (P = .021) and maximum CSA (P = .007) demonstrated quadriceps atrophy. However, only the ACL-deficient limb of the older (mean ± SD age, 27.4 ± 11.4 versus 19.9 ± 3.3 years; P = .032) and lower-activity-level (3.3 ± 0.5 versus 3.6 ± 0.5; P = .098) noncoper group demonstrated reduced rectus femoris (P = .057) and lateral hamstring (P = .064) neuromuscular control in comparison to their uninvolved limb. Conclusion These findings suggest that quadriceps and hamstring muscle function, rather than muscle size, may be an important factor in the varied response early after ACL injury. J Orthop Sports Phys Ther 2014;44(2):76–84. Epub 21 November 2013. doi:10.2519/jospt.2014.4876
Evolution of leaf anatomy and photosynthetic pathways in Portulacaceae
Authors: Ocampo Gilberto , Koteyeva Nuria K. , Voznesenskaya Elena V. , Edwards Gerald E. , Sage Tammy L. , Sage Rowan F. , Columbus J. Travis 
Published: November 2013

• Premise of the study: Portulacaceae is a family with a remarkable diversity in photosynthetic pathways. This lineage not only has species with different C4 biochemistry (NADP‐ME and NAD‐ME types) and C3‐C4 intermediacy, but also displays different leaf anatomical configurations. Here we addressed the evolutionary history of leaf anatomy and photosynthetic pathways in Portulacaceae.• Methods: Photosynthetic pathways were assessed based on leaf anatomy and carbon isotope ratios. Information on the NADP‐ME and NAD‐ME C4 variants was obtained from the literature. The evolutionary relationships and trait evolution were estimated under a Bayesian framework, and divergence times were calibrated using the ages obtained in a previous study.• Key results: C4 photosynthesis is the main pathway in Portulacaceae. One clade (Cryptopetala), however, includes species that have non‐Kranz anatomy and C3 type isotope values, two of which are C3‐C4 intermediates. The ancestral leaf anatomy for the family is uncertain. The analysis showed one origin of the C4 pathway, which was lost in the Cryptopetala clade. Nevertheless, when a second analysis was performed taking into account the limited number of species with NAD‐ME and NADP‐ME data, a secondary gain of the C4 pathway from a C3‐C4 intermediate was inferred.• Conclusions: The C4 pathway evolved ca. 23 Myr in the Portulacaceae. The number of times that the pathway evolved in the family is uncertain. The diversity of leaf anatomical types and C4 biochemical variants suggest multiple independent origins of C4 photosynthesis. Evidence for a switch from C4 to C3‐C4 intermediacy supports the hypothesis that intermediates represent a distinct successful strategy.
Créativité-habitude : le divorce improbable du travail enseignant. Le cas de l'éducation physique et sportive.
Authors: Jelen Nathalie , Necker Sophie 
Published: November 2013

À partir de l’analyse de matériaux issus d’une enquête qualitative auprès d’enseignants du secondaire, combinant entretiens et observations in situ , cet article vise à examiner l’interaction entre deux phases de l’activité du travail : la créativité et l’habitude. Comment, dans les pratiques enseignantes, se déclinent, se distinguent et interagissent créativité et habitude ? Quels sont les facteurs qui les induisent ? Comment et sous quelles conditions la création devient-elle routine et la routine source de création ? Nous discuterons de leur complémentarité en étudiant l’activité de l’enseignant, sa recherche d’une relative stabilité dans les interactions sociales visant à favoriser l’apprentissage des élèves en EPS. Ainsi, l’analyse du travail « en train de se faire » met en évidence différents facteurs agissant sur l’articulation créativité/habitude. Les processus et procédés distinctifs identifiés renvoient aux caractéristiques des acteurs, aux diverses interactions sociales hors et dans la classe (face aux élèves, avec les collègues) ainsi qu’au poids des attendus sociaux et de l’évaluation subjective des effets de l’expérimentation.
Implant Imaging
Authors: Bhoosreddy Ajay R , Bhoosreddy Seema , Shirsekar Vinayak Umesh 
Published: November 2013

ABSTRACT
Implants improve the quality of life for patients who are unable to keep their natural teeth, fix acute problems, and give patients the benefit of restorative improvements for a modern lifestyle. The greatest key to successful implant placement is accurate preplacement assessment. Imaging plays a pivotal role in preplacement assessment. Success of dental implant restorations is in part, dependent on adequate diagnostic information about the bony structures of the oral region. This article reviews the applications of different imaging technologies and their diagnostic contribution to presurgical evaluation, treatment planning and postoperative assessment of dental implants.

How to cite this article
Bhoosreddy AR, Bhoosreddy S, Shirsekar VU. Implant Imaging. J Contemp Dent 2013;3(3): 127-132.
Treatment of Skeletal Class II Malocclusion Using a Fixed Functional Appliance
Authors: Sonawane Manish Suresh , Karandikar Girish Ramchandra , Shah Shaili Sanjay , Kulkarni Vinayak Shridharrao , Burad Hitesh Jagadish 
Published: November 2013

ABSTRACT
Treatment of class II malocclusion has always been an enigma to the orthodontic fraternity. Noncompliant correction of class II malocclusion using fixed functional appliances at the deceleration stage of growth has gained tremendous popularity in the recent times. Aim of the illustrated article is to demonstrate the efficacy of a fixed functional appliance in correction of class II malocclusion. We are reporting a 12-year-old female patient with a skeletal class II malocclusion treated using the Forsus appliance. Forsus FRD was the best option considering age, patient comfort, ease of installation, predictable results and patient compliance. The appliance was worn for 5 months after the initial alignment with fixed mechanotherapy (MBT 0.022"). The mandible was brought forward to a class I skeletal and dental relationship by the end of this phase of treatment.

How to cite this article
Shah SS, Karandikar GR, Sonawane MS, Kulkarni VS, Burad HJ. Treatment of Skeletal Class II Malocclusion Using a Fixed Functional Appliance. J Contemp Dent 2013;3(3):153-158.
Attachments: A Boon for Hemimandibulectomy Patients
Authors: Nadgere Jyoti B , Chandavarkar Saili Mohan , Gurav Sandeep 
Published: November 2013

ABSTRACTDiscontinuity defects in the mandible cause various ill effects like imbalance in the muscles of the lower face, facial disfigurement, restriction of tongue causing alteration of speech and altered salivation. It leads to decreased mandibular function by deviation of the residual segment toward the surgical side and affects masticatory function adversely. Postoperative care and prosthodontic rehabilitation required in hemimandibulectomy patients is interdisciplinary including surgical management, prosthodontic treatment, speech therapy, oral physiotherapy and psychologic care. It is difficult to provide a functional, retentive and stable prosthesis to such patients. In the described case report, a hemimandibulectomy patient was successfully rehabilitated by providing maxillary and mandibular overdentures with intraradicular ball attachments on natural teeth. This treatment option was a simple, convenient and economical method of enhancing denture retention and stability; and providing security and comfort to the patient.How to cite this articleChandavarkar SM, Ram SM, Gurav S, Nadgere JB, Shah N. Attachments: A Boon for Hemimandibulectomy Patients. J Contemp Dent 2013;3(3):159-164.
A Sense of Stile Rhetoric in Edgar Allan Poe's “Never Bet the Devil Your Head”
Authors: Dern John A. 
Published: November 2013

Abstract
Is Poe's “Never Bet the Devil Your Head” a mere trifle, or is it a tale warranting serious attention? More than just a satirical farce, this overtly comic story from 1841 is a rhetorical lampoon of what Daniel Royot dubs “the Transcendentalist postulation of secret essence.” Deriving archetypal elements of plot and characterization from two earlier Poe tales, “The Bargain Lost” and “Bon-Bon,” “Never Bet the Devil Your Head” combines “the fantastic” with what Poe labels “the quaint in phraseology.” In other words, Poe unleashes a tale of uncertain identity, rhetorical flourish, and double meaning, where the hapless victim of an ill-fated pigeon-wing over a turnstile may or may not be a boy's pet dog. If he is a dog, the protagonist is no ordinary dog, but an oath-making product of the narrator's fancy, acting in comic juxtaposition with the narrator's erudite schemes of language—and his penchant for whingeing. If he is not a dog, however, then he is no less ill-fated owing to a lack of what J. A. Cuddon calls the Transcendentalist emphasis on “individual conscience.” Still, the real lesson of “Never Bet the Devil Your Head” is not the titular moral, but the satirical substitution of rhetorical minutiae for “secret essence.”
Purloined Letters Edgar Allan Poe, Maria Edgeworth, and the Study of Chirography
Authors: Tarr Clayton Carlyle 
Published: November 2013

Abstract
Letters, both political and amorous, prove vital to the plot of Maria Edgeworth's Helen (1834), but to this point no text had been so concerned with the potential hazards of epistolary promiscuity once handwriting is transformed to print. Edgeworth champions the subjectivity of handwriting over the machinery of print because the former reveals hidden attributes about the writer's character. Edgar Allan Poe follows Edgeworth in placing importance on the intersections between chirography and character, but that is not where the influence between the authors stopped. In Helen, the eponymous heroine demonstrates her dynamic agency through a capacity for detective work, as she solves a vital case of theft and extortion through visual and circumstantial evidence. Although Lady Davenant keeps her letters in a desk equipped with a reliable lock, the Portuguese boy she employs nevertheless manages to steal them. Helen's detective work places the agency of perception squarely on the shoulders of a woman and prefigures the customs of detective fiction later recognizable in Poe's short stories.
Decentralized simple adaptive control of nonlinear systems
Authors: Ulrich Steve , Sasiadek Jurek Z. 
Published: November 2013

SUMMARYRecently, the passivity results for linear time‐invariant systems were successfully extended to nonlinear and nonstationary systems, thus guaranteeing stability of adaptive control of nonlinear square systems. Based on this theoretical development, this paper presents the development of a new class of direct adaptive controllers, which employ a new decentralized adaptation law mechanism that is developed from the simple adaptive control technique. The resulting direct adaptive control methodology is referred to as decentralized simple adaptive control. A simplification of this new control algorithm, referred to as decentralized modified simple adaptive control, is also presented. In addition, it is shown that both control methodologies can be modified to avoid divergence in practical situations, where the trajectory tracking errors cannot reach zero. Using Lyapunov direct method and Lasalle's invariance principle for nonautonomous systems, the formal proof of stability is established. As well, a numerical simulation study for a trajectory tracking problem by a rigid‐joint manipulator is presented to illustrate the new adaptive control approaches. Copyright © 2013 John Wiley & Sons, Ltd.
Overgrowth syndrome associated with a gain‐of‐function mutation of the natriuretic peptide receptor 2 (NPR2) gene
Authors: Miura Kohji , Kim Ok‐Hwa , Lee Hey Ran , Namba Noriyuki , Michigami Toshimi , Yoo Won Joon , Choi In Ho , Ozono Keiichi , Cho Tae‐Joon 
Published: November 2013

ABSTRACTThe signal pathway of the C‐type natriuretic (CNP) and its receptor, natriuretic peptide receptor 2 (NPR2) is involved in the longitudinal growth of long bones. Loss of function mutations at NPR2 cause acromesomelic dysplasia, type Maroteaux, while overproduction of CNP by chromosomal translocation and a gain‐of‐function mutation at NPR2 have been reported to be responsible for an overgrowth syndrome in three cases and one family, respectively. We identified a four‐generation family with an overgrowth syndrome characterized by tall stature, macrodactyly of the great toes, scoliosis, coxa valga and slipped capital femoral epiphysis, similar to those previously reported in association with CNP/NPR2 overactivity. The serum level of amino‐terminal proCNP was normal in the proband. A novel missense mutation of NPR2, c.1462G>C (p.Ala488Pro) was found to co‐segregate with the phenotype in this family. In vitro transfection assay of the mutant NPR2 revealed overactivity of the mutant receptor at baseline as well as with the ligand. This overgrowth syndrome caused by a gain‐of‐function mutation at NPR2 should be differentiated from Marfan or related syndromes, and may be categorized along with the overgrowth syndrome caused by overproduction of CNP due to its phenotypical similarity as overgrowth CNP/NPR2 signalopathy. © 2013 Wiley Periodicals, Inc.