bluuebunny/crossref_metadata_2025_split huggingface dataset:
Future projected impacts of ocean warming to potential squid habitat in western and central North Pacific
Authors: Alabia Irene D. , Saitoh Sei-Ichi , Igarashi Hiromichi , Ishikawa Yoichi , Usui Norihisa , Kamachi Masafumi , Awaji Toshiyuki , Seito Masaki 
Published: November 2015

Abstract
Climate-driven changes in the marine ecosystem largely influence the distribution, abundance, and the consequent availability of marine resources to the fishery. In this study, we examined the potential habitat distributions of the neon flying squid (Ommastrephes bartramii) under the projected impacts of ocean warming. We used the sea surface temperature (SST) from the three CMIP5 climate scenarios (RCP4.5, RCP6.0, and RCP8.5) with the low to high future emissions. Based on the squid habitat models, SST showed the highest effect on the present potential squid habitat distribution that accounted for at least 60% of the predicted spatial patterns from May to July 2000–2010. This result underpinned the species' high sensitivity to the temperature changes in its feeding environments. Moreover, the projected future potential squid habitats revealed pronounced differences in the spatial and temporal patterns relative to the present habitat distributions across the different regions of the western and central North Pacific. The future squid habitat predictions revealed a net reduction in the suitable squid habitat coupled with the corresponding northward habitat retreat. Moreover, the magnitude of the predicted habitat changes was proportional to the levels of warming for the representative periods from May to July 2025, 2050, and 2100. The highest decrease in the spatial extent and poleward retreat of the potential squid habitat were observed from May to July 2100 under the RCP 8.5 scenario. These trends could translate to shorter squid fishing periods and offshore shifts of the squid fishing grounds. Thus, insights into the future spatio-temporal patterns and trajectories of the potential squid habitats could lend important implications on the availability of squid resources to the fishery and subsequent evaluation of squid fishery management options under climate change.
Effects of long-term exposure to ocean acidification conditions on future southern Tanner crab (Chionoecetes bairdi) fisheries management
Authors: Punt André E. , Foy Robert J. , Dalton Michael G. , Long W. Christopher , Swiney Katherine M. 
Published: November 2015

AbstractDemographic models of pre- and post-recruitment population dynamics were developed to account for the effects of ocean acidification on biological parameters that affect southern Tanner crab (Chionoecetes bairdi) larval hatching success and larval and juvenile survival. Projections of stock biomass based on these linked models were used to calculate biological and economic reference points on which fisheries management advice is based and thus provide fisheries managers with strategic advice on the likely long-term consequences of ocean acidification. The models utilized information for southern Tanner crab in the eastern Bering Sea. This information included the monitoring data on which conventional size-structured stock assessments are based, as well as the functional relationships that determine survival based on experiments that evaluated the consequences of ocean acidification over the next 100–200 years on crab larval hatching success, larval survival, and the survival of juvenile crab. The results highlighted that juvenile survival had the largest effect (∼20% decrease over 75 years) on biological and economic reference points, while hatching success, particularly if density dependence occurs after hatching, and larval survival have smaller effects (&lt;10% decrease). Catch and profits would be expected to decrease by &gt;50% in 20 years if natural mortality is affected by ocean acidification. Additional laboratory data on oocyte and embryo development leads to large changes in biological reference points depending on the timing of ocean acidification effects relative to natural mortality. The results highlight the need for experiments to evaluate the longer term physiological effects of ocean acidification on multiple life history stages and to measure indices that directly inform population dynamics models to evaluate future management scenarios.
Fate of the other redcoat: remnants of colonial British foxes in the eastern United States
Authors: Kasprowicz Adrienne E. , Statham Mark J. , Sacks Benjamin N. 
Published: November 2015

AbstractRed foxes were absent or rare in the southeastern United States until the late 1800s. Their origins potentially include natural population increase/expansion, translocations from Europe, and, eventually, 20th century fur farming. Previous studies have found no European haplotypes in North America, but few samples were sourced from the Atlantic coastal plain, closer to the source of putative introductions. Through analysis of mitochondrial DNA in 584 red foxes from this region, we identified indigenous haplotypes in ≥ 35% of foxes, 1 of 2 European haplotypes in 17% of foxes and fur farm haplotypes in ≥ 13% of foxes; another 35% of foxes had haplotypes potentially indigenous or native. In contrast, only 3 of 135 (2%) male foxes carried a single European Y chromosome haplotype. Most European and fur farm haplotypes were found near the densely human-populated coastal plain and Hudson River lowlands; most red foxes of the Appalachians and Piedmont had native eastern haplotypes. Our findings suggest that the more remote, upland populations primarily reflect indigenous red fox matrilines, whereas urban-associated populations in and around the mid-Atlantic coastal plain and Hudson lowlands reflect an admixture of native and nonnative maternal sources. Autosomal markers are needed to further elucidate the extent of European and fur farm introgression in the Appalachians and further west.
Perceptions of Peer-to-Peer Interprofessional Feedback Among Students in the Health Professions
Authors: van Schaik Sandrijn M. , Regehr Glenn , Eva Kevin W. , Irby David M. , O’Sullivan Patricia S. 
Published: November 2015

Purpose
Interprofessional teamwork should include interprofessional feedback to optimize performance and collaboration. Social identity theory predicts that hierarchy and stereotypes may limit receptiveness to interprofessional feedback, but literature on this is sparse. This study explores perceptions among health professions students regarding interprofessional peer feedback received after a team exercise.

Method
In 2012–2013, students from seven health professions schools (medicine, pharmacy, nursing, dentistry, physical therapy, dietetics, and social work) participated in a team-based interprofessional exercise early in clinical training. Afterward, they wrote anonymous feedback comments for each other. Each student subsequently completed an online survey to rate the usefulness and positivity (on five-point scales) of feedback received and guessed each comment’s source. Data analysis included analysis of variance to examine interactions (on usefulness and positivity ratings) between profession of feedback recipients and providers.

Results
Of 353 study participants, 242 (68.6%) accessed the feedback and 221 (62.6%) completed the survey. Overall, students perceived the feedback as useful (means across professions = 3.84–4.27) and positive (means = 4.17–4.86). There was no main effect of profession of the feedback provider, and no interactions between profession of recipient and profession of provider regardless of whether the actual or guessed provider profession was entered into the analysis.

Conclusions
These findings suggest that students have positive perceptions of interprofessional feedback without systematic bias against any specific group. Whether students actually use interprofessional feedback for performance improvement and remain receptive toward such feedback as they progress in their professional education deserves further study.
Television-Related Head Injuries in Children
Authors: Lichenstein Richard , Monroe David , Quayle Kimberly S. , Miskin Michelle , Cooper Arthur , Gerardi Michael J. , Callahan James M. , Dayan Peter S. , Holmes James F. , Kuppermann Nathan ,   for the Pediatric Emergency Care Applied Research Network (PECARN)
Published: November 2015

Objective
The objective of the study was to describe the epidemiology, cranial computed tomography (CT) findings, and clinical outcomes of children with blunt head trauma after television tip-over injuries.

Methods
We performed a secondary analysis of children younger than 18 years prospectively evaluated for blunt head trauma at 25 emergency departments (EDs) in the Pediatric Emergency Care Applied Research Network from June 2004 to September 2006. Children injured from falling televisions were included. Patients were excluded if injuries occurred more than 24 hours before ED evaluation or if neuroimaging was obtained before evaluation. Data collected included age, race, sex, cranial CT findings, and clinical outcomes. Clinically important traumatic brain injuries (ciTBIs) were defined as death from TBI, neurosurgery, intubation for more than 24 hours for the TBI, or hospital admission of 2 nights or more for the head injury, in association with TBI on CT.

Results
A total of 43,904 children were enrolled into the primary study and 218 (0.5%; 95% confidence interval [CI], 0.4% to 0.6%) were struck by falling televisions. The median (interquartile range) age of the 218 patients was 3.1 (1.9–4.9) years. Seventy-five (34%) of the 218 underwent CT scanning. Ten (13.3%; 95% CI, 6.6% to 23.2%) of the 75 patients with an ED CT had traumatic findings on cranial CT scan. Six patients met the criteria for ciTBI. Three of these patients died. All 6 patients with ciTBIs were younger than 5 years.

Conclusions
Television tip-overs may cause ciTBIs in children, including death, and the most severe injuries occur in children 5 years or younger. These injuries may be preventable by simple preventive measures such as anchoring television sets with straps.
Modularity and Morphometrics: Error Rates in Hypothesis Testing
Authors: Garcia Guilherme , de Oliveira Felipe Bandoni , Marroig Gabriel 
Published: November 2015

AbstractThe study of modularity in morphological systems has increased in the past twenty years, parallel to the popularization of geometric morphometrics, which has led to the emergence of different criteria for detecting modularity on landmark data. However, compared to usual covariance matrix estimators, Procrustes estimators have properties that hinder their use. Here, we compare different representations of form, focusing on detecting modularity patterns defineda priori;we also compare two metrics: one derived from traditional morphometrics (MHI) and another that emerged in the context of landmark data (RV). Using Anthropoid skulls, we compare these metrics over three representations of form: interlandmark distances, Procrustes residuals, and local shape variables. Over Procrustes residuals, both tests fail to detect modularity patterns, while in remaining representations they show the distinction between early and late development in skull ontogeny. To estimate type I and II error rates, we built covariance matrices of known structure; these tests indicate that, considering both effect and sample sizes, tests using MHI are more robust than those using RV. However, both metrics have low power when used on Procrustes residuals. Thus, we conclude that the influence of development and function is poorly represented on Procrustes estimators for covariance matrices.
Dynamical Model of Drug Accumulation in Bacteria: Sensitivity Analysis and Experimentally Testable Predictions
Authors: Vesselinova Neda , Alexandrov Boian S. , Wall Michael E. 
Published: November 2015

AbstractWe present a dynamical model of drug accumulation in bacteria. The model captures key features in experimental time courses on ofloxacin accumulation: initial uptake; two-phase response; and long-term acclimation. In combination with experimental data, the model provides estimates of import and export rates in each phase, the time of entry into the second phase, and the decrease of internal drug during acclimation. Global sensitivity analysis, local sensitivity analysis, and Bayesian sensitivity analysis of the model provide information about the robustness of these estimates, and about the relative importance of different parameters in determining the features of the accumulation time courses in three different bacterial species:Escherichia coli, Staphylococcus aureus, andPseudomonas aeruginosa. The results lead to experimentally testable predictions of the effects of membrane permeability, drug efflux and trapping (e.g., by DNA binding) on drug accumulation. A key prediction is that a sudden increase in ofloxacin accumulation in bothE. coliandS. aureusis accompanied by a decrease in membrane permeability.Author SummaryBacteria live or die depending on how much antibiotic gets inside them. Using a simple mathematical model, detailed information about drug import and export can be teased out of time courses of internal drug levels after a sudden exposure. The results suggest that membrane permeability can suddenly decrease during exposure to drug, accompanied by an increase, rather than a decrease, in the internal drug level.
Strongly asymmetric hybridization barriers shape the origin of a new polyploid species and its hybrid ancestor
Authors: Vallejo-Marin Marío , Cooley Arielle M. , Yue Qi Michelle Lee , Folmer Madison , McKain Michael R. , Puzey Joshua R. 
Published: November 2015

ABSTRACTPremise of the study:Hybridization between diploids and tetraploids can lead to new allopolyploid species, often via a triploid intermediate. Viable triploids are often produced asymmetrically, with greater success observed for “maternal-excess” crosses where the mother has a higher ploidy than the father. Here we investigate the evolutionary origins ofMimulus peregrinus, an allohexaploid recently derived from the triploidM. x robertsii, to determine whether reproductive asymmetry has shaped the formation of this new species.Methods:We used reciprocal crosses between the diploid (M. guttatus) and tetraploid (M. luteus) progenitors to determine the viability of triploidM. x robertsiihybrids resulting from paternal-versus maternal-excess crosses. To investigate whether experimental results predict patterns seen in the field, we performed parentage analyses comparing natural populations ofM. peregrinusto its diploid, tetraploid, and triploid progenitors. Organellar sequences obtained from pre-existing genomic data, supplemented with additional genotyping was used to establish the maternal ancestry of multipleM. peregrinusandM. x robertsiipopulations.Key results:We find strong evidence for asymmetric origins ofM. peregrinus, but opposite to the common pattern, with paternal-excess crosses significantly more successful than maternal-excess crosses. These results successfully predicted hybrid formation in nature: 111 of 114M. x robertsiiindividuals, and 27 of 27M. peregrinus, had anM. guttatusmaternal haplotype.Conclusion:This study, which includes the firstMimuluschloroplast genome assembly, demonstrates the utility of parentage analysis through genome skimming. We highlight the benefits of complementing genomic analyses with experimental approaches to understand asymmetry in allopolyploid speciation.
Targeted mutations on 3D hub loci alter spatial interaction environment
Authors: Ding Bo , Zheng Lina , Medovoy David , Wang Wei 
Published: November 2015

AbstractMany disease-related genotype variations (GVs) reside in non-gene coding regions and the mechanisms of their association with diseases are largely unknown. A possible impact of GVs on disease formation is to alter the spatial organization of chromosome. However, the relationship between GVs and 3D genome structure has not been studied at the chromosome scale. The kilobase resolution of chromosomal structures measured by Hi-C have provided an unprecedented opportunity to tackle this problem. Here we proposed a network-based method to capture global properties of the chromosomal structure. We uncovered that genome organization is scale free and the genomic loci interacting with many other loci in space, termed as hubs, are critical for stabilizing local chromosomal structure. Importantly, we found that cancer-specific GVs target hubs to drastically alter the local chromosomal interactions. These analyses revealed the general principles of 3D genome organization and provided a new direction to pinpoint genotype variations in non-coding regions that are critical for disease formation.
A computational model of inhibition of HIV-1 by interferon-alpha
Authors: Browne Edward P , Letham Benjamin , Rudin Cynthia 
Published: November 2015

AbstractType 1 interferons such as interferon-alpha (IFNα) inhibit replication of Human immunodeficiency virus (HIV-1) by upregulating the expression of genes that interfere with specific steps in the viral life cycle. This pathway thus represents a potential target for immune-based therapies that can alter the dynamics of host-virus interactions to benefit the host. To obtain a deeper mechanistic understanding of how IFNα impacts spreading HIV-1 infection, we modeled the interaction of HIV-1 with CD4 T cells and IFNαas a dynamical system. This model was then tested using experimental data from a cell culture model of spreading HIV-1 infection. We found that a model in which IFNαinduces reversible cellular states that block both early and late stages of HIV-1 infection, combined with a saturating rate of conversion to these states, was able to successfully fit the experimental dataset. Sensitivity analysis showed that the potency of inhibition by IFNαwas particularly dependent on specific network parameters and rate constants. This model will be useful for designing new therapies targeting the IFNαnetwork in HIV-1-infected individuals, as well as potentially serving as a template for understanding the interaction of IFNαwith other viruses.Author SummaryInterferon-alpha (IFNα) is a key component of the host response to HIV-1, but the details of how IFNαregulates infection are still incompletely understood. To provide a deeper understanding of the dynamics of how IFNαinhibits HIV-1, we simulated the interaction of IFNαand HIV-1 as a computational model and compared this model to an experimental dataset. We identify a model structure that is able to fit many key features of the data. Furthermore, we use the model to predict optimal strategies for targeting the IFNαpathway therapeutically. We anticipate that this model will be useful for further analysis of HIV-IFNα interactions and will help to guide new therapeutic strategies.
Excessive drinking of fluids in children and adults on the autism spectrum: a brief report
Authors: Mills Richard , Wing Lorna 
Published: November 2015

Purpose
– Excessive drinking of fluids occurs across the autism spectrum but despite the detrimental and potentially hazardous consequences very few studies of this phenomenon have been published. Literature on the topic is sparse. The purpose of this paper is to explore the issues via a large on-line survey and a clinic sample. It is hoped this study will encourage further interest in and investigation including exploration of the links with the neurology underlying autistic conditions.

Design/methodology/approach
– Results were obtained via a large on-line survey of autistic individuals and parents and carers (n=637) and data from referrals to a single diagnostic assessment and diagnostic clinic.

Findings
– Of 634 respondents of the on-line survey 474 reported excessive drinking of fluids in severe form. Almost two-thirds stated that this started before the age of five years. Of the children and adults seen at the clinic approximately one-third had dunk fluids excessively in the past. The effects of gender, type of autism condition, intellectual disability, reported stress and associated conditions were examined as were the type of fluids drunk and rate of drinking. The response to having to wait for a drink and the occurrence of vomiting and diarrhoea were also examined.

Research limitations/implications
– This is a preliminary study but with a large sample size. Limitations lie in the sparse amount of literature on this topic as it affects autism and reliance on parental and self-reports from an on-line survey, the majority of whom responded to an appeal for participants for whom excessive drinking of fluids was an established problem. The clinic sample comprised children and adults who had not been referred for reasons connected to excessive drinking of fluids but for whom this was still a significant problem. A further limitation concerns the absence of data on sensory profiles. This would be worth including in any follow up.

Practical implications
– It is important to be aware of the implications of excessive drinking of fluids on the health and well-being of children and adults on the autism spectrum. As there are potentially lethal consequences associated with such behaviours it is essential that they are recognised, understood and responded to.

Social implications
– Excessive drinking of fluids has implications for the development of the child and far reaching consequences for physical and social well-being.

Originality/value
– This is an original paper that draws on the limited literature available but is primarily based on the results of a unique on-line survey and evaluation of a clinic sample.
The brand origin meaning transfer model (BOMT): an integrative theoretical model
Authors: D'Antone Simona , Merunka Dwight 
Published: November 2015

Purpose
– The purpose of this paper is to explore how brand origin (BO) cues affect the consumer’s association of a new brand with BO learning and the subsequent effects on brand image (BO semiotics). An integrative theoretical framework is proposed that includes both processes.

Design/methodology/approach
– The proposed model is based on analogical learning theory and triadic semiotic theory.

Findings
– Two types of BO knowledge form BO meanings in consumer minds: country-related categories and exemplar brands, which have a classification and/or inferential role. The brand cues (indexes or icons) used by consumers to identify BO generate one or the other type of BO knowledge. Indexes trigger the classification function of country-related categories while icons trigger the inferential role of country-related categories and exemplar brands. BO knowledge informs the meaning transfer when consumers interpret the meaning of a new brand, leading to either a transfer of relations or a transfer of attributes to the new brand.

Practical implications
– Marketers should monitor BO exemplar brands that consumers use as meaning sources and carefully select the signs used in their communications to evoke BO.

Originality/value
– The proposed framework contrasts with dominant categorisation perspectives, re-establishing the dual role of categories and emphasising the relevance of brand cues in BO identification and BO exemplar brands in the BO meaning transfer process. A meaning-centred perspective is adopted to integrate BO identification and the related transfer mechanisms.