bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sublingual 400 μg Misoprostol vs Intravenous 0.2 mg Methylergometrine for Active Management of Third Stage of Labor
Authors: Bhute Sindhu , Shrivastava Deepti , Khamsara Deepali , Pandey Poonam 
Published: August 2013

ABSTRACT

Objectives
To compare the efficacy and side effects of sublingual 400 μg misoprostol with 0.2 mg intravenous methylergometrine in active management of third stage of labor.

Materials and methods
In a prospective, randomized comparative study conduted in Department of Obstetrics and Gynecology, AVBRH, Wardha, 200 women at full-term gestation, without any high risk factors were studied in two groups of 100 each, for safety and efficacy of 400 μg sublingual misoprostol in comparison to 0.2 mg intravenous methylergometrine at the delivery of anterior shoulder from December 2010 to November 2011. Main parameters used were duration of 3rd stage, amount of blood loss, need of aditional uterotonic, complications of third stage, drop in hemoglobin and side effects. Results were analyzed by Student's t-test.

Results
Mean duration of third stage in misoprostol group was 9.67 ± 1.98 min, amount of blood loss was 203 ± 24 ml, need of additional uterotonics was 13%, drop in hemoglobin 0.59 ± 0.79 which were almost comparable with other group and side effects were mainly shivering and pyrexia in misoprostol group and vomiting and giddiness in methergine group.

Conclusion
Sublingual 400 μg misoprostol is almost equally effective as intravenous methergine for active management of third stage of labor with advantage of simplicity of storage of drug, route of administration and no risk of injection associated infections, which make it very much relevant in rural scenario.

How to cite this article
Shrivastava D, Khamsara D, Pandey P, Bhute S. Sublingual 400 μg Misoprostol vs Intravenous 0.2 mg Methylergometrine for Active Management of Third Stage of Labor. J South Asian Feder Obst Gynae 2013;5(1):15-18.
Labor Analgesia: An Unmet Right of Laboring Women in India
Authors: Sharma Sudha , Menia Vinay , Bedi Jyoti , Dogra Sonica 
Published: August 2013

ABSTRACTLabor pain has been described as one of the worst pain experienced by women in their lives. Medical science has made a continuous effort in this field to find a better method to alleviate the pain of labor. Since the historical use of ether for labor analgesia (1847) various pharmacological and nonpharmacological methods for labor analgesia have been evolved, each having its own merits and demerits. But even today the hunt by medical science continues to find an ideal method for labor analgesia (simple, cheap, effective, easily available, and free of side effects). To date neuroaxial/regional analgesia remains the gold standard method for labor analgesia. More than 5 decades have passed since the establishment of its effectiveness and safety profile but even today it is not available to most laboring women in India, and the concept of labor analgesia is like a fairy tale story to them. High patient load in hospitals, high cost of equipment and poor doctor/patient ratio are important obstacles for this. Thus, providing labor analgesia which is a right of every woman remains an unmet need.How to cite this articleSharma S, Menia V, Bedi J, Dogra S. Labor Analgesia: An Unmet Right of Laboring Women in India. J South Asian Feder Obst Gynae 2013;5(1):26-32.
Uterine Leiomyoma presenting with Hemoperitoneum
Authors: Dahiya Krishna , Walecha Nymphaea 
Published: August 2013

ABSTRACTBleeding from uterine leiomyoma is a rare cause of hemoperitoneum. Although extremely rare, spontaneous bleeding from uterine leiomyoma should be in the differential diagnosis when there is no history of trauma, pregnancy, or other findings. This case report highlights that spontaneous vascular rupture in a fibroid can cause acute cardiovascular collapse, and that this should be borne in mind in cases of acute abdomen, especially in the presence of an abdomino-pelvic mass. Because surgical intervention is the only definitive treatment, emergency physicians should be aware of this rare complication.How to cite this articleDahiya K, Walecha N. Uterine Leiomyoma presenting with Hemoperitoneum. J South Asian Feder Obst Gynae 2013;5(1):33-34.
A Rare Case of Portal Vein Cavernoma with Pregnancy
Authors: Gawande Madhuri , Ghike Sunita , Jain Sheela , Mitra Kajal , Senani Sanjana , Ratnaparkhi Chetna 
Published: August 2013

ABSTRACT
Portal vein cavernoma is a rare disease resulting from extrahepatic portal vein thrombosis and development from collateral venous circulation. It is a rare condition affecting both adults and children with equal gender distribution. Both local and systemic factors may contribute to development of portal vein thrombosis. Once there is portal vein thrombosis, cavernous transformation occurs in 5 weeks to 12 months of thrombotic event. We report a case of primigravida with portal vein cavernoma who presented to us in last trimester. Cesarean section was done with primary indication with premature rupture of membrane with poor bishop score. Cesarean section was given priority considering associated digestive varices. Both maternal and fetal outcome was good.

How to cite this article
Ghike S, Gawande M, Mitra K, Jain S, Senani S, Ratnaparkhi C. A Rare Case of Portal Vein Cavernoma with Pregnancy. J South Asian Feder Obst Gynae 2013;5(1):37-39.
Rare Case of Prolapsing Vaginal Cyst
Authors: Shah Neha , Valecha Shalini Mahana , Gandhewar Manisha , Shende Prajakta 
Published: August 2013

ABSTRACT
Müllerian cysts typically are <2 cm in size and asymptomatic. Our patient presented with big mass coming out per vaginum and intermittent vaginal discharge. A provisional diagnosis of first degree uterovaginal descent with cystorectocele with small right lateral vaginal wall cyst was made. The patient was posted for vaginal hysterectomy with anteroposterior colporrhaphy with excision of the cyst. What we thought was a routine vaginal hysterectomy for prolapse allotting another few minutes for a small cyst removal, turned out to be a complicated procedure, requiring additional time and expertize. Not all patients presenting with mass coming out per vaginum, necessarily, are a case of prolapse. One should not minimize the importance of vaginal wall cysts, irrespective of their size. A detailed evaluation, using MRI scan is indicated, prior to proceeding with their removal.

How to cite this article
Valecha SM, Shah N, Gandhewar M, Shende P. Rare Case of Prolapsing Vaginal Cyst. J South Asian Feder Obst Gynae 2013;5(1):40-41.
Preparation, characterization, and performance evaluation of coated PES polymer materials fabricated via dry/wet phase inversion technique
Authors: Kim KeeHong , Hyung ChanHeui , Ingole Pravin G. , Kim JongHak , Lee HyungKeun 
Published: August 2013

ABSTRACTSulfur dioxide (SO2) is the major air pollutant which is emitted from the power plant. In this study, hollow fiber membrane (HFM) separation process is applied for the improvement of SO2 removal efficiency in the post‐combustion gas. HFM was produced by dry/wet phase inversion method and then coated with Polydimethylsiloxane (PDMS). The membrane morphology and characterization were examined with help of scanning electron microscope (SEM), energy dispersion of X‐ray spectroscopy (EDX), Fourier transform infrared (FT‐IR) and atomic force microscopy (AFM). Polyethersulfone (PES) hollow fiber membranes were tested for the SO2/N2 binary mixed gas separation. Single gas permeance of SO2, N2, and binary mixture gas (200 ppm of SO2) separation experiment was initiated to observe membrane behavior according to temperature and pressure difference and retentate flow rate. As a result, permeance of SO2 was 24.9–47.4 GPU and selectivity of SO2/N2 was 1.6–4.2. From the mixture gas separation experiment, SO2 removal efficiency increased according to stage cut and operating pressure. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39711.
Lignin‐xylaric acid‐polyurethane‐based polymer network systems: Preparation and characterization
Authors: Pohjanlehto Helinä , Setälä Harri M. , Kiely Donald E. , McDonald Armando G. 
Published: August 2013

ABSTRACTPolyurethanes (PU) were synthesized from lignin by first preparing a prepolymer from esterified sugar‐based trihydroxyl compound xylaric acid and a 20 mol % excess of methylene diphenyl diisocyanate. The prepolymer was crosslinked with 5, 10, and 15 wt % of an industrial soda lignin, and polyethylene glycol was used to bring soft segments into the material structure. The total amount of bio‐based starting materials was as high as 35%. Evidence for the reaction between the prepolymer and lignin was observed using Fourier transform infrared spectroscopic analysis and 13C nuclear magnetic resonance spectroscopy. The thermal properties of the materials were investigated by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The mechanical and viscoelastic properties of the materials were determined by dynamic mechanical analysis (DMA). The glass transition temperatures (Tg) obtained from DSC and DMA showed a trend of increasing Tg with the increasing amount of lignin. A similar trend was observed with TGA for the increasing thermal stability up to 550oC with the increasing amount of lignin. The lignin‐polyurethanes obtained were stiff materials showing high Young's modulus values. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39714.
Theoretical and Experimental Analysis of the Reaction Mechanism of MrTPS2, a Triquinane‐Forming Sesquiterpene Synthase from Chamomile
Authors: Hong Young J. , Irmisch Sandra , Wang Selina C. , Garms Stefan , Gershenzon Jonathan , Zu Liansuo , Köllner Tobias G. , Tantillo Dean J. 
Published: August 2013

AbstractTerpene synthases, as key enzymes of terpene biosynthesis, have garnered the attention of chemists and biologists for many years. Their carbocationic reaction mechanisms are responsible for the huge variety of terpene structures in nature. These mechanisms are amenable to study by using classical biochemical approaches as well as computational analysis, and in this study we combine quantum‐chemical calculations and deuterium‐labeling experiments to elucidate the reaction mechanism of a triquinane forming sesquiterpene synthase from chamomile. Our results suggest that the reaction from farnesyl diphosphate to triquinanes proceeds through caryophyllyl and presilphiperfolanyl cations and involves the protonation of a stable (−)‐(E)‐β‐caryophyllene intermediate. A tyrosine residue was identified that appears to be involved in the proton‐transfer process.
Functionalized Organotin‐Chalcogenide Complexes That Exhibit Defect Heterocubane Scaffolds: Formation, Synthesis, and Characterization
Authors: Eußner Jens P. , Barth Beatrix E. K. , Leusmann Eliza , You Zhiliang , Rinn Niklas , Dehnen Stefanie 
Published: August 2013

AbstractThe synthesis of new functionalized organotin‐chalcogenide complexes was achieved by systematic optimization of the reaction conditions. The structures of compounds [(R1, 2Sn)3S4Cl] (1, 2), [((R2Sn)2SnS4)2(μ‐S)2] (3), [(R1, 2Sn)3Se4][SnCl3] (4, 5), and [Li(thf)n][(R3Sn)(HR3Sn)2Se4Cl] (6), in which R1=CMe2CH2C(O)Me, R2=CMe2CH2C(NNH2)Me, and R3=CH2CH2COO, are based on defect heterocubane scaffolds, as shown by X‐ray diffraction, 119Sn NMR spectroscopy, and ESI mass spectrometry analyses. Compounds 4, 5, and 6 constitute the first examples of defect heterocubane‐type metal‐chalcogenide complexes that are comprised of selenide ligands. Comprehensive DFT calculations prompted us to search for the formal intermediates [(R1SnCl2)2(μ‐S)] (7) and [(R1SnCl)2(μ‐S)2] (8), which were isolated and helped to understand the stepwise formation of compounds 1–6.
Allenylidene Complexes Based on Pentacenequinone
Authors: Strinitz Frank , Waterloo Andreas , Tucher Johannes , Hübner Eike , Tykwinski Rik R. , Burzlaff Nicolai 
Published: August 2013

AbstractStable ruthenium–allenylidene complexes based on pentacenequinone have been synthesized. The complexes show an electronic absorption in the NIR region that arises from forbidden MLCT transitions, as explained by DFT calculations. The crystal structure reveals promising features for the formation of metal‐influenced organic FETs.
Synthesis and Crystal Structures of [(iPr3P)2Cu(μ‐ESiMe3)(InMe3)] (E = S, Se): Lewis Acid–Base Adducts with Chalcogen Atoms in Planar Coordination
Authors: Biedermann Ralf , Kluge Oliver , Fuhrmann Daniel , Krautscheid Harald 
Published: August 2013

AbstractThe structures of [(iPr3P)2Cu(μ‐SSiMe3)(InMe3)] and [(iPr3P)2Cu(μ‐SeSiMe3)(InMe3)] were determined by single‐crystal X‐ray diffraction. Both complexes are Lewis acid–base adducts of the InMe3 acceptor and the chalcogen donor atom linking a Me3Si group and a (iPr3P)2Cu moiety. They are very unstable under atmospheric conditions and decompose at ambient temperatures. Results of DFT calculations for these complexes and the related hypothetical [(Me3P)2Cu(μ‐SSiMe3)(InMe3)] compound show that the unusual planar coordination of the chalcogen atoms is due to steric crowding.
Ionic‐Liquid‐Assisted Synthesis of Self‐Assembled TiO2‐B Nanosheets under Microwave Irradiation and Their Enhanced Lithium Storage Properties
Authors: Chen Chaoji , Hu Xianluo , Hu Pei , Qiao Yun , Qie Long , Huang Yunhui 
Published: August 2013

AbstractSelf‐assembled TiO2‐B nanosheets have been successfully synthesized by a rapid, one‐pot, ionic‐liquid‐assisted solvothermal route under microwave irritation. By adjusting the reaction temperature, reaction time, and reactant concentration, the morphology and phase of the as‐formed TiO2‐B nanostructures can be tailored. The unique role of the ionic liquid in the formation of self‐assembled TiO2 nanosheets has been investigated in detail, and a plausible growth mechanism has been proposed. Owing to the synergetic superiority of hierarchical porosity, a fast pseudocapacitive reaction, and large surface area, the electrode prepared from the self‐assembled porous TiO2‐B nanostructures exhibits high reversible capacity, excellent cyclability, and superior rate capability. The synthetic procedure is simple, efficient, and scalable for mass production. Therefore the as‐formed self‐assembled TiO2‐B nanosheets may offer great potential for next‐generation rechargeable batteries with high‐power densities, and are flexible building blocks for advanced functional devices.
Evaluating the sorption of organophosphate esters to different sourced humic acids and its effects on the toxicity to Daphnia magna
Authors: Pang Long , Liu Jingfu , Yin Yongguang , Shen Mohai 
Published: August 2013

Abstract

Because of large usage as flame retardants and additives, organophosphate esters (OPEs) are widely detected in the environment and regarded as emerging contaminants. However, the sorption of OPEs to organic matter and its effects have scarcely been studied. In the present study, the sorption of 9 commonly used OPEs to 4 representative humic acids—Elliott Soil humic acid, Suwannee River humic acid, Aldrich humic acid, and Acros humic acid—in the range of 0 mg/L to 50 mg/L dissolved organic carbon (DOC), was evaluated with negligible-depletion solid-phase microextraction and verified by its impacts on the toxicity to the aquatic invertebrate Daphnia magna. Whereas OPEs with a high octanol/water partition coefficient (log KOW = 4.51 − 6.64) were associated with humic acids mainly by hydrophobic interaction with DOC partition coefficient (KDOC) in the range of 102.22 to 105.31, the sorption of low-KOW OPEs (log KOW = −0.65 to 2.59) to humic acids was not hydrophobic interaction–dominant, with KDOC in the range of 103.47 to 104.29. These results were corroborated by the effects of humic acids on the acute toxicity of 3 high-KOW OPEs to D. magna. The sorption of OPEs to Suwannee River humic acid was weak and had negligible effects on the toxicity of high-KOW OPEs; the presence of terrestrial Acros humic acid (50 mg/L DOC), however, significantly decreased the toxicity by 53% to 60%. The results indicated that the strong sorption between high-KOW OPEs and terrestrial humic acid might affect their transportation and bioavailability. Environ Toxicol Chem 2013;32:2755–2761. © 2013 SETAC
Photosynthetic and cellular toxicity of cadmium in Chlorella vulgaris
Authors: Ou-Yang Hui-Ling , Kong Xiang-Zhen , Lavoie Michel , He Wei , Qin Ning , He Qi-Shuang , Yang Bin , Wang Rong , Xu Fu-Liu 
Published: August 2013

Abstract

The toxic effects of cadmium (Cd) on the green alga Chlorella vulgaris were investigated by following the response to Cd of various toxicity endpoints (cell growth, cell size, photochemical efficiency of PSII in the light or ΦPSII , maximal photochemical efficiency or Fv/Fm, chlorophyll a fluorescence, esterase activity, and cell viability). These toxicity endpoints were studied in laboratory batch cultures of C. vulgaris over a long-term 96-h exposure to different Cd concentrations using flow cytometry and pulse amplitude modulated fluorometry. The sequence of sensitivity of these toxicity endpoints was: cell yield &gt;&gt; ΦPSII ≈ esterase activity &gt; Fv/Fm &gt; chlorophyll a fluorescence ≈ cell viability. It is shown that cell apoptosis or cell death only accounted for a minor part of the reduction in cell yield even at very high algistatic free Cd2+ concentrations, and other mechanisms such as blocked cell divisions are major contributors to cell yield inhibition. Furthermore, cadmium may affect both the electron donors and acceptors of the electron transport chain at high free Cd2+ concentration. Finally, the resistance of cells to cell death was size-dependent; medium-sized cells had the highest toxicity threshold. The present study brings new insights into the toxicity mechanisms of Cd in C. vulgaris and provides a detailed comparison of the sensitivity of various Cd toxicity endpoints. Environ Toxicol Chem 2013;32:2762–2770. © 2013 SETAC
Sinonasal adenocarcinoma: A 16‐year experience at a single institution
Authors: Bhayani Mihir K. , Yilmaz Turker , Sweeney Alex , Calzada Gabriel , Roberts Dianna B. , Levine Nicholas B. , DeMonte Franco , Hanna Ehab Y. , Kupferman Michael E. 
Published: August 2013

AbstractBackgroundAdenocarcinoma is a rare tumor of the sinonasal tract. The purpose of this study was to characterize a single institution's experience with this malignancy.MethodsRetrospective review was performed of patients with adenocarcinoma of the sinonasal tract from 1993 to 2009. Demographic data, disease presentation, treatment, and survival rates were collected and evaluated.ResultsWe identified 66 patients with sinonasal adenocarcinoma; 48 were men and 18 women. Average age at time of diagnosis was 57.1 years (range, 20–88 years), and median follow‐up was 55.3 months (range, 1–238 months). The ethmoid sinus (38%) and nasal cavity (36%) were the most common sites of origin. Nasal obstruction (36%), epistaxis (30%), and nasal discharge (21%) were the most common presenting symptoms. Fifty‐one percent of patients presented with T1 or T2 tumors. Surgery was the primary form of treatment in 81% of patients. Twenty‐six percent of surgical patients underwent an endoscopic tumor resection. Adjuvant radiation was utilized in 50% of patients and chemotherapy in 10%. Recurrence was seen in 24 patients (37%): 29% recurred locally and 7.6% recurred distantly. The overall 5‐year survival was 65.9%. Survival was decreased significantly in patients with T4 tumors (p < .05), high‐grade histology (p < .05), and sphenoid sinus involvement (p < .05). Survival was not affected by surgical approach between endoscopic and open approaches (p = .76).ConclusionSinonasal adenocarcinomas are commonly identified in the sinonasal cavity and are associated with a relatively favorable prognosis, despite a substantial local failure rate of 30%. Advanced‐stage tumors, sphenoid sinus and skull base invasion, and high‐grade histology portend poor prognosis. In our experience, endoscopic resection was not associated with adverse outcomes and suggests that this minimally invasive approach can provide acceptable oncologic outcomes in selected patients. © 2014 Wiley Periodicals, Inc. Head Neck, 36: 1490–1496, 2014
No clinical evidence for performing trough plasma and intracellular imatinib concentrations monitoring in patients with chronic myelogenous leukaemia
Authors: Racil Zdenek , Razga Filip , Klamova Hana , Voglova Jaroslava , Belohlavkova Petra , Malaskova Ludmila , Potesil David , Muzik Jan , Zackova Daniela , Polakova Katerina Machova , Zdrahal Zbynek , Malakova Jana , Suttnar Jiri , Dyr Jan , Mayer Jiri 
Published: August 2013

AbstractThis multicentre study focused on monitoring imatinib mesylate (IMA) trough plasma (Ctrough) and intracellular (IMA Cintrac) concentrations in 228 chronic myelogenous leukaemia patients. The median of measured IMA Ctrough in our patient group was 905.8 ng ml (range: 27.7–4628.1 ng/ml). We found a correlation between IMA Ctrough and alpha 1‐acid glycoprotein plasma concentrations (rS = 0.42; p < 0.001). All other analysed parameters revealed only weak (gender, dose of IMA per kg) or not significant (age, albumin, creatinine plasma concentration or body mass index) impact on measured IMA Ctrough. The IMA Ctrough decreased during the first 6 months and significantly increased later during treatment. The IMA Ctrough at the first month of therapy did not differ between patients with and without an optimal response at the 12th (p = 0.724) and 18th month (p = 0.135) of therapy. There were no significant differences in medians of IMA Ctrough between both groups measured during the first year of treatment. The IMA Cintrac during the first month were not different between patients with and without an optimal response at the 6th (p = 0.273) and the 12th month (p = 0.193) of therapy. Our data obtained from real life clinical practice did not find a benefit of routine and regular IMA Ctrough nor IMA Cintrac therapeutic drug monitoring in chronic myelogenous leukaemia patients or for subsequent adjustments of the IMA dose based on these results. Moreover, actual alpha 1‐acid glycoprotein plasma concentration should be used for proper interpretation of IMA Ctrough results. Copyright © 2013 John Wiley & Sons, Ltd.
A review of topical high‐concentration L‐menthol as a translational model of cold allodynia and hyperalgesia
Authors: Andersen H.H. , Olsen R.V. , Møller H.G. , Eskelund P.W. , Gazerani P. , Arendt‐Nielsen L. 
Published: August 2013

AbstractBackgroundCold allodynia and cold hyperalgesia are both elusive features of neuropathic pain, particularly in patients with various polyneuropathies. Numerous studies have suggested that topical application of L‐menthol causes temporary cold hypersensitivity and thus acts as a proxy for associated symptoms. This review summarizes studies on L‐menthol‐induced nociception, cold allodynia and cold hyperalgesia in vitro, in animals and in humans.MethodsA comprehensive literature search was performed using the PubMed and Google Scholar databases until February 2013. Obtained manuscripts were reviewed for relevancy and reference lists of the retrieved articles were cross‐checked for additional important studies. Solely the literature regarding topical application of L‐menthol in humans was attained systematically. Of the total identified studies (96), 10 met the inclusion criteria being controlled studies applying L‐menthol at a concentration of ≥30%.ResultsThe extracted data are meticulously compared and presented with emphasis on clarity and transparency. In seven animal studies, cold allodynia or hyperalgesia was successfully established utilizing various methods. Eight studies in healthy volunteers unanimously reported a significant increase in cold pain threshold, representing cold allodynia and increased supra‐threshold cold pain sensitivity, thus demonstrating cold hyperalgesia.ConclusionsTopical high‐concentration L‐menthol consistently induces cold hypersensitivity in animals and humans, thus constituting a predictable surrogate model of cold allodynia and hyperalgesia. Understanding translational features of this model and its underlying mechanisms could be valuable in preclinical and human phases of drug development and in improving current treatment of patients with polyneuropathy.