bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rational Topological Design for Fluorescence Enhancement upon Aggregation of Distyrylfuran Derivatives
Authors: Mallet Charlotte , Moussallem Chady , Faurie Alexandre , Allain Magali , Gohier Frédéric , Skene William G. , Frère Pierre 
Published: April 2015

AbstractA series of 2,5‐distyrylfuran derivatives bearing pentafluorophenyl‐ and cyanovinyl units have been synthesized for aggregation‐induced emission (AIE). The effect of the type and extent of the supramolecular connections on the AIE of the furan derivatives were examined and correlated with their X‐ray crystal structures. It was found that the simultaneous presence of cyano and perfluorophenyl units strongly enhances the fluorescence upon aggregation. Single‐crystal X‐ray diffraction analysis confirmed that CH⋅⋅⋅F, F⋅⋅⋅F, CH⋅⋅⋅nitrile, Ar⋅⋅⋅ArF (Ar=aryl, ArF=fluoroaryl), and nitrile⋅⋅⋅ArF intra‐ and intermolecular interactions drive the topology of the molecule and that solid‐state supramolecular contacts favor AIE of the furan derivatives.
Stable [48]‐, [50]‐, and [52]Dodecaphyrins(1.1.0.1.1.0.1.1.0.1.1.0): The Largest Hückel Aromatic Molecules
Authors: Soya Takanori , Kim Woojae , Kim Dongho , Osuka Atsuhiro 
Published: April 2015

Abstract[52]Dodecaphyrin(1.1.0.1.1.0.1.1.0.1.1.0) was quantitatively oxidized with 2,3‐dichloro‐5,6‐dicyano‐1,4‐benzoquinone (DDQ) to the corresponding [50]dodecaphyrin. Further oxidation of [50]dodecaphyrin with MnO2 quantitatively afforded [48]dodecaphyrin. Of the three, [50]dodecaphyrin showed Hückel aromatic character as the largest aromatic molecule reported to date. Protonation of [50]dodecaphyrin with methanesulfonic acid (MSA) led to the formation of a planar tetraprotonated species that displayed a sharp and intense Soret‐like band at 906 nm with ε=6.5×105 M−1 cm−1 and Q‐band‐like bands at 1346 and 1600 nm.
(S)‐BINOL Immobilized onto Multiwalled Carbon Nanotubes through Covalent Linkage: A New Approach for Hybrid Nanomaterials Characterization
Authors: Monteiro Carlos J. P. , Carabineiro Sónia A. C. , Lauterbach Tobias , Hubbert Christoph , Hashmi A. Stephen K. , Figueiredo José L. , Pereira Mariette M. 
Published: April 2015

Abstract(S)‐6‐(4‐(Methoxycarbonyl)phenyl)‐1,1′‐bis‐2‐naphthol, a chiral 1,1′‐bis‐2‐naphthol (BINOL) derivative, was prepared via Suzuki C−C coupling and immobilized onto diamine‐functionalized multiwalled carbon nanotubes. The BINOL was first derivatized with a carboxylic acid, capable of forming an amide linkage with the amine–carbon nanotube modified surface. The 4‐methoxyphenylboronic acid was replaced by 3‐fluoro‐4‐(methoxycarbonyl)phenylboronic acid and (S)‐6‐(3‐fluoro‐4‐(methoxycarbonyl)phenyl)‐1,1′‐bis‐2‐naphthol was obtained and used as a probe to better quantify the organic material. It was found that in the hybrid material, 1/3 of amine groups have been transformed into the corresponding amide (S)‐BINOL derivative. The chemical and electronic integrity of the chiral BINOL ligand is maintained after the ligand immobilization. Evaluation in diethyl zinc and Ti(OiPr)4‐catalyzed alkylation of benzaldehyde showed that both methoxycarbonylphenyl and fluoromethoxycarbonylphenyl BINOL moieties do not significantly influence the catalytic activity or selectivity of the process. However, when hybrid materials were used, similar activities were obtained, but with lower enantioselectivities. This result could be due to a competitive alkylation reaction occurring on the carbon surface or by the constraint caused by the ligand proximity on the support surface.
Ligand‐Induced Evolution of Intrinsic Fluorescence and Catalytic Activity from Cobalt Ferrite Nanoparticles
Authors: Pal Monalisa , Kundu Anirban , Rakshit Rupali , Mandal Kalyan 
Published: April 2015

AbstractTo develop CoFe2O4 as magneto‐fluorescent nanoparticles (NPs) for biomedical applications, it would be advantageous to identify any intrinsic fluorescence of this important magnetic material by simply adjusting the surface chemistry of the NPs themselves. Herein, we demonstrate that intrinsic multicolor fluorescence, covering the whole visible region, can be induced by facile functionalization of CoFe2O4 NPs with Na‐tartrate. Moreover, the functionalized CoFe2O4 NPs also show unprecedented catalytic efficiency in the degradation of both biologically and environmentally harmful dyes, pioneering the potential application of these NPs in therapeutics and wastewater treatment. Detailed investigation through various spectroscopic tools unveils the story behind the emergence of this unique optical property of CoFe2O4 NPs upon functionalization with tartrate ligands. We believe our developed multifunctional CoFe2O4 NPs hold great promise for advanced biomedical and technological applications.
Advances in toponomics drug discovery: Imaging cycler microscopy correctly predicts a therapy method of amyotrophic lateral sclerosis
Authors: Schubert Walter 
Published: April 2015

AbstractAn imaging cycler microscope (ICM) is a fully automated (epi)fluorescence microscope which overcomes the spectral resolution limit resulting in parameter‐ and dimension‐unlimited fluorescence imaging. This enables the spatial resolution of large molecular systems with their emergent topological properties (toponome) in morphologically intact cells and tissues displaying thousands of multi protein assemblies at a time. The resulting combinatorial geometry of these systems has been shown to be key for in‐vivo/in‐situ detection of lead proteins controlling protein network topology and (dys)function: If lead proteins are blocked or downregulated the corresponding disease protein network disassembles. Here, correct therapeutic predictions are exemplified for ALS. ICM drug target studies have discovered an 18‐dimensional cell surface molecular system in ALS‐PBMC with a lead drug target protein, whose therapeutic downregulation is now reported to show statistically significant effect with stop of disease progression in one third of the ALS patients. Together, this clinical and the earlier experimental validations of the ICM approach indicate that ICM readily discovers in vivo robustness nodes of disease with lead proteins controlling them. Breaking in vivo robustness nodes using drugs against their lead proteins is likely to overcome current high drug attrition rates. © 2015 The Author. Published by Wiley Periodicals, Inc, on behalf of ISAC.
Indirect selection of thermal tolerance during experimental evolution of Drosophila melanogaster
Authors: Condon Catriona , Acharya Ajjya , Adrian Gregory J. , Hurliman Alex M. , Malekooti David , Nguyen Phivu , Zelic Maximilian H. , Angilletta Michael J. 
Published: April 2015

AbstractNatural selection alters the distribution of a trait in a population and indirectly alters the distribution of genetically correlated traits. Long‐standing models of thermal adaptation assume that trade‐offs exist between fitness at different temperatures; however, experimental evolution often fails to reveal such trade‐offs. Here, we show that adaptation to benign temperatures in experimental populations of Drosophila melanogaster resulted in correlated responses at the boundaries of the thermal niche. Specifically, adaptation to fluctuating temperatures (16–25°C) decreased tolerance of extreme heat. Surprisingly, flies adapted to a constant temperature of 25°C had greater cold tolerance than did flies adapted to other thermal conditions, including a constant temperature of 16°C. As our populations were never exposed to extreme temperatures during selection, divergence of thermal tolerance likely reflects indirect selection of standing genetic variation via linkage or pleiotropy. We found no relationship between heat and cold tolerances in these populations. Our results show that the thermal niche evolves by direct and indirect selection, in ways that are more complicated than assumed by theoretical models.
Warming experiments elucidate the drivers of observed directional changes in tundra vegetation
Authors: Hollister Robert D. , May Jeremy L. , Kremers Kelseyann S. , Tweedie Craig E. , Oberbauer Steven F. , Liebig Jennifer A. , Botting Timothy F. , Barrett Robert T. , Gregory Jessica L. 
Published: April 2015

AbstractFew studies have clearly linked long‐term monitoring with in situ experiments to clarify potential drivers of observed change at a given site. This is especially necessary when findings from a site are applied to a much broader geographic area. Here, we document vegetation change at Barrow and Atqasuk, Alaska, occurring naturally and due to experimental warming over nearly two decades. An examination of plant cover, canopy height, and community indices showed more significant differences between years than due to experimental warming. However, changes with warming were more consistent than changes between years and were cumulative in many cases. Most cases of directional change observed in the control plots over time corresponded with a directional change in response to experimental warming. These included increases in canopy height and decreases in lichen cover. Experimental warming resulted in additional increases in evergreen shrub cover and decreases in diversity and bryophyte cover. This study suggests that the directional changes occurring at the sites are primarily due to warming and indicates that further changes are likely in the next two decades if the regional warming trend continues. These findings provide an example of the utility of coupling in situ experiments with long‐term monitoring to accurately document vegetation change in response to global change and to identify the underlying mechanisms driving observed changes.
Effects of flow regulation on the movement patterns and habitat use of a potamodromous cyprinid species
Authors: Alexandre C. M. , Almeida P. R. , Neves T. , Mateus C. S. , Costa J. L. , Quintella B. R. 
Published: April 2015

AbstractRiver regulation for hydroelectricity production results in rapid changes of flow and habitat features, but its effects in the movement patterns of freshwater fish are not well understood. Radiotelemetry was used to track Iberian barbel during a year cycle in non‐regulated and regulated rivers. We applied a kernel density method to estimate and compare home range sizes of the two populations. Seasonal patterns of movement and the intra‐annual variation in habitat preferences were also compared. Barbel inhabiting regulated river exhibit larger and more continuous home and core ranges, in opposition to the smaller and patchy areas used by fish inhabiting the non‐regulated river. Seasonal movements of both populations were differentiated by the drought period. Barbel from the non‐regulated river had to search for suitable refuges, with specific habitat characteristics, in which they remained aggregated during harsh summer conditions. Conversely, barbel from regulated river kept a continuous distribution along the river. This study contributes to the management of regulated rivers by providing insights about which flow components are more altered by hydropeaking operations and which are the most critical annual periods for fish movements. It also suggests several restoration actions, such as the protection of fish summer refuges, the restoration of large‐scale temporal streamflow variability and the reduction of daily rates of discharge rise and fall, which should be continuously monitored in order to increase their efficiency and provide new knowledge. Copyright © 2015 John Wiley & Sons, Ltd.
Electrochemical and Spectroelectrochemical Analysis of 4‐(4‐(5‐Phenyl‐1,3,4‐oxadiazole‐2‐yl)phenoxy)‐Substituted Cobalt(II), Lead(II) and Metal‐Free Phthalocyanines
Authors: Nas Asiye , Kantekin Halit , Koca Atıf 
Published: April 2015

AbstractElectrochemical and spectroelectrochemical analyses of 4‐(4‐(5‐phenyl‐1,3,4‐oxadiazole‐2‐yl)phenoxy)‐substituted metal‐free phthalocyanine (H2Pc (1)) and metallated phthalocyanines (PbPc (2) and CoPc (3)) were performed in solution. Voltammetric characterizations of the phthalocyanine complexes were investigated by using cyclic voltammetry and square wave voltammetry techniques. CoPc (3) gave common metal and ring based electron transfer reactions; however they split due to the aggregation. Although PbPc (2) illustrated reversible reduction processes during the voltammetric measurements, it was de‐metallized and thus turned to the metal free phthalocyanine during repetitive voltammetric cycles and in situ spectroelectrochemical measurements.
Nanostructured Cobalt(II) Tetracarboxyphthalocyanine Complex Supported Within the MWCNT Frameworks: Electron Transport and Charge Storage Capabilities
Authors: Pillay Sherilee , Pillay Jeseelan , Ejikeme Paul M. , Makgopa Katlego , Ozoemena Kenneth I. 
Published: April 2015

AbstractThe electrochemical redox properties of a surface‐confined thin solid film of nanostructured cobalt(II) tetracarboxyphthalocyanine integrated with multiwalled carbon nanotube (nanoCoTCPc/MWCNT) have been investigated. This novel nanoCoTCPc/MWCNT material was characterized using SEM, TEM, zeta analysis and electrochemical methods. The nanoCoTCPc/MWCNT nanohybrid material exhibited an extra‐ordinarily high conductivity (15 mS cm−1), which is more than an order of magnitude greater than that of the MWCNT‐SO3H (527 µS cm−1) and three orders of a magnitude greater than the nanoCoTCPc (4.33 µS cm−1). The heterogeneous electron transfer rate constant decreases as follows: nanoCoTCPc/MWCNT (kapp≈19.73×10−3 cm s−1)>MWCNT‐SO3H (kapp≈11.63×10−3 cm s−1)>nanoCoTCPc (kapp≈1.09×10−3 cm s−1). The energy‐storage capability was typical of pseudocapacitive behaviour; at a current density of 10 µA cm−2, the pseudocapacitance decreases as nanoCoTCPc/MWCNT (3.71×10−4 F cm−2)>nanoCoTCPc (2.57×10−4 F cm−2)>MWCNT‐SO3H (2.28×10−4 F cm−2). The new nanoCoTCPc/MWCNT nanohybrid material promises to serve as a potential material for the fabrication of thin film electrocatalysts or energy‐storage devices.
Partially Oxidized Graphene/Metallic Single‐Walled Carbon Nanotubes Film‐Coated Electrode for Nanomolar Detection of Dopamine
Authors: Sundramoorthy Ashok K. , Gunasekaran Sundaram 
Published: April 2015

AbstractEnriched metallic single‐walled carbon nanotubes (mSWCNTs) were dispersed in aqueous solution of partially oxidized graphene (po‐Gr). As‐prepared po‐Gr/mSWCNTs suspension was used to modify glassy carbon electrode (GCE) surface, which showed high electrocatalytic activity for dopamine (DA) oxidation in pH 7.0 phosphate buffered saline (PBS) solution. Using po‐Gr/mSWCNTs/GCE we could detect DA from 350 to 3600 nM, with a detection limit down to 25 nM in physiological condition (in pH 7.0 PBS); whereas, po‐Gr/GCE (without mSWCNTs) and bare GCE produced measurable signals only at or above 200 nM DA. Thus, the po‐Gr/mSWCNTs film we fabricated is a promising nanomaterial for fabrication of biosensors for nanomolar detection of DA.
Wings as a new route of exposure to pesticides in the honey bee
Authors: Poquet Yannick , Kairo Guillaume , Tchamitchian Sylvie , Brunet Jean-Luc , Belzunces Luc P. 
Published: April 2015

Abstract

In pesticide risk assessment, estimating the routes and levels of exposure is critical. For honey bees subjected to pesticide spray, toxicity is assessed by thorax contact to account for all possible contact exposures. In the present study, the authors tested 6 active substances with different hydrophobicity. For the first time, the authors demonstrated that it is possible to induce mortality by pesticide contact with only the wings of the honey bee. The toxicities induced by contact with the wings and thorax were similar, with the wing median lethal dose (LD50) being 0.99 to 2.23 times higher than that of the thorax. This finding demonstrates that the wings represent a relevant route of exposure in the honey bee. In a second approach, the authors estimated the air volume displaced by the wings during 1 beating cycle to be 0.51 ± 0.03 cm3, which corresponds to a volume of 116.8 ± 5.8 cm3 s–1 at a wing beat frequency of 230 Hz. The authors then tested realistic scenarios of exposure for bees flying through a pesticide cloud at different concentrations. In the worst-case scenario, the dose accumulated during the flight reached 525 ng bee–1 s–1. These results show that the procedure used to assess the risk posed by contact with pesticides could be improved by accounting for wing exposure. Environ Toxicol Chem 2015;34:1983–1988. © 2015 SETAC
An energy‐reduced dietary pattern, including moderate protein and increased nonfat dairy intake combined with walking promotes beneficial body composition and metabolic changes in women with excess adiposity: a randomized comparative trial
Authors: Shlisky Julie D. , Durward Carrie M. , Zack Melissa K. , Gugger Carolyn K. , Campbell Jessica K. , Nickols‐Richardson Sharon M. 
Published: April 2015

AbstractModerate protein and nonfat dairy intake within an energy‐reduced diet (ERD) may contribute to health benefits achieved with body weight (BW) loss. The current study examined the effectiveness of a weight‐loss/weight‐loss maintenance intervention using an ERD with moderate dietary protein (30% of kcals) and increased nonfat dairy intake (4–5 svg/d), including yogurt (INT group) and daily walking compared to an ERD with standard protein (16–17% of kcals) and standard nonfat dairy intake (3 svg/d) (COM group) with daily walking. A randomized comparative trial with 104 healthy premenopausal women with overweight/obesity was conducted in a university setting. Women were randomized to INT group or COM group. Anthropometric measurements, as well as dietary intake, selected vital signs, resting energy expenditure, blood lipids, glucose, insulin, and selected adipose‐derived hormones were measured at baseline, and weeks 2, 12, and 24. Targets for dietary protein and nonfat dairy intake, while initially achieved, were not sustained in the INT group. There were no significant effects of diet group on anthropometric measurements. Women in the INT group and COM group, respectively, reduced BW (−4.9 ± 3.2 and −4.3 ± 3.3 kg, P < 0.001) and fat mass (−3.0 ± 2.2 and −2.3 ± 2.3 kg, P < 0.001) during the 12‐week weight‐loss phase and maintained these losses at 24 weeks. Both groups experienced significant decreases in body mass index, fat‐free soft tissue mass, body fat percentage, waist and hip circumferences and serum triglycerides, total cholesterol, and leptin (all P < 0.001). Healthy premenopausal women with excess adiposity effectively lost BW and fat mass and improved some metabolic risk factors following an ERD with approximately 20% protein and 3 svg/d of nonfat dairy intake.
Ectopic intravagal parathyroid adenoma
Authors: Daruwalla Jurstine , Sachithanandan Nirupa , Andrews David , Miller Julie A. 
Published: April 2015

AbstractBackgroundIntraneural parathyroid adenomas are rare, with only 9 cases of intravagal adenomas reported. All but one of the reported cases was found after multiple neck explorations. To the best of our knowledge, we report the first case of nonsupernumerary ectopic intravagal parathyroid identified at primary exploration.Methods and ResultsA 17‐year‐old girl with primary hyperparathyroidism and nephrolithiasis was referred with a sestamibi scan reporting a left lower parathyroid adenoma. No eutopic parathyroid tissue was identified during full exploration of the left side of the neck. Exploration of the carotid sheath revealed a fusiform swelling of the vagus nerve at the level of the carotid bifurcation. Longitudinal incision of the vagal perineurium revealed a 7‐mm parathyroid adenoma, which was enucleated. The patient recovered uneventfully, with normalization of serum calcium, parathyroid hormone (PTH), and normal vocal cord function.ConclusionWe believe that this is the first reported case of nonsupernumerary intravagal parathyroid adenoma resected at initial exploration. The vagus nerve is a rare location for a parathyroid adenoma, but one that should be considered, even during primary exploration. © 2015 Wiley Periodicals, Inc. Head Neck 37: E200–E204, 2015
Summer evapotranspiration in western Siberia: a comparison between eddy covariance and Penman method formulations
Authors: Fleischer Elisa , Bölter Jana , Klemm Otto 
Published: April 2015

AbstractEvapotranspiration is difficult to quantify because of the many factors and complex processes that influence it. Several empirical methods have been developed over the years to estimate potential evapotranspiration based on easily available parameters. Directly measured data of actual evapotranspiration have been rather sparse in the past and still need to be improved in particular regions like western Siberia. The transition zone between the warm temperate and cold temperate continental climates is very sensitive to climate change, and water stress is an increasingly important issue in these regions with a highly dynamic agricultural activity. So there is a growing need to estimate actual evapotranspiration. Widely usable approximations are needed. In this study, the values of potential evapotranspiration computed with the original version, and eight modifications of the Penman formulation were compared and related to the actual evapotranspiration measured by eddy covariance over a grassland area in western Siberia. The original 1948 and 1963 Penman formulations are best for estimating potential evapotranspiration in the transition zone between the forest steppes and the pre‐taiga. A nearly linear relationship between the potential and actual evapotranspiration was found. A simple modification of the Penman equation (i.e. the multiplication of the result by a factor of 0.47) is suggested for approximating the actual evapotranspiration based on standard meteorological data for the region.The original Penman formulation is most robust and will provide the widest applicability in the future under changing climate and environmental conditions. In this context, it is further recommended not to neglect the ventilation term of the Penman equation, which is often assumed to be negligibly small. A detailed correlation analysis showed that under dry soil conditions, the vegetation largely contributed to the actual evapotranspiration and, in contrast to widely held expectations, that the Penman equation is best adapted to vegetated surfaces. Copyright © 2015 John Wiley & Sons, Ltd.
Impact of an Educational Program on Antibiotic Use in Paediatric Appendectomy Procedures
Authors: Angalakuditi Mallik , Sunderland V Bruce , Roberts Malcolm J , Turner Sean , Lilley Brian J 
Published: April 2015

ABSTRACTAimTo evaluate antibiotic use in paediatric appendectomy procedures.MethodDemographic, clinical and antibiotic prescribing data for patients who had appendectomies were reviewed in two paediatric hospitals retrospectively (pre‐intervention). The data was analysed against standard guidelines for abdominal surgery. A multifaceted education strategy was designed and administered only in the case hospital. A post‐intervention evaluation was conducted in both hospitals (case and control).Results207 cases and 224 controls were evaluated. There was no significant difference (p > 0.05) between gender, age and length of stay between the groups. Post‐intervention, appropriateness of theatre antibiotics changed from 0 to 65% (cases) and from 52.9% to 53.3% (controls). The appropriateness of ward antibiotics changed from 48 to 84.7% (cases) and 76.4 to 71.4% (controls). The total antibiotic dosage appropriateness changed from 0 to 58.2% (cases) and 12 to 3.8% (controls).ConclusionAntibiotic use significantly improved following the multifaceted educational intervention.