bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactions Between River Floods and Human Activities on Sediment Transport in a Macrotidal Estuary
Authors: Yan Yuhan , Song Dehai , Huang Junbao , Han Yu , Xie Dongfeng , Bao Xianwen 
Published: August 2024

AbstractRiver floods and human activities would impact land‐to‐sea sediment transport, which is essential for understanding the evolution of the global sediment cycle in the Anthropocene era. This study focused on investigating how river floods and a dike constructed in 2005 along a river channel influence sediment transport from the Ou River Estuary to the East China Sea. A validated three‐dimensional sediment transport model based on the Finite Volume Community Ocean Model was utilized for this study. The presence of the dike obstructs alongshore currents and fish migrations, leading to negative effects on marine ecology. Therefore, selective dismantling and ecological restoration measures are deemed necessary. Three scenarios were considered in this study: no‐dike, dike‐constructed, and dike‐partially‐removed conditions, along with various types of river floods. The findings indicate that the monthly sediment flux to the sea decreased by 7.7% from 8.11 × 106 to 7.49 × 106 t following dike construction, while the proportion of cross‐shore sediment flux to the total flux increased from 37% to 59%. The dike consistently has a greater impact than river floods in their interactions. However, partially removing the dike reduces its influence and restores sediment transport to pre‐dike levels, the effectiveness of which is more pronounced with more frequent floods, larger volumes, and rising sea levels. This study provides valuable insights into the interplay between river floods and dikes on sediment transport, thereby enhancing our understanding of the repercussions of human interventions on sediment dynamics.
Association Between Prenatal Exposure to Per‐ and Poly‐Fluoroalkyl Substances From Electronic Waste Disassembly Areas and Steroid Hormones in Human Milk Samples
Authors: Li Qiyao , Zhang Yan , Chen Chen , Lou Jianlin , Wang Shenghang , Hang Jin Guo , Nakayama Shoji F. , Kido Teruhiko , Feng Hao , Sun Xian Liang , Shan Jiancong 
Published: August 2024

AbstractPer‐ and poly‐fluoroalkyl substances (PFAS), which are long‐lasting environmental contaminants that are released into the environment during the e‐waste disassembly process, pose a threat to human health. Human milk is a complex and dynamic mixture of endogenous and exogenous substances, including steroid hormones and PFAS. Therefore, in this study, we aimed to investigate the association between PFAS and steroid hormones in human milk from women living close to an e‐waste disassembly area. In 2021, we collected milk samples from 150 mothers within 4 weeks of delivery and analyzed them via liquid chromatography‐tandem mass spectrometry to determine the levels of 21 perfluorinated compounds and five steroid hormones (estrone, estriol, testosterone, progesterone, and androstenedione [A‐dione]). We also performed multiple linear regression analysis to clarify the association between maternal PFAS exposure and steroid hormone concentrations. Our results indicated that PFOA and PFOS were positively associated with estrone (β, 0.23; 95% CI, 0.08–0.39) and A‐dione (β, 0.186; 95% CI, 0.016–0.357) concentrations in human milk, respectively. Further, the average estimated daily intake of PFOA and PFOS were 36.5 ng/kg bw/day (range, 0.52–291.7 ng/kg bw/day) and 5.21 ng/kg bw/day (range, 0.26–32.3 ng/kg bw/day), respectively. Of concern, the PFAS intake of breastfeeding infants in the study area was higher than the recommended threshold. These findings suggested that prenatal exposure to PFAS from the e‐waste disassembly process can influence steroid hormones levels in human milk. Increased efforts to mitigate mother and infant exposure to environmental pollutants are also required.
Novel fetal phenotype of TAF8 deficiency
Authors: Nadav Golan , Odeh Marwan , Mesika Aviv , Abarbanel Har-Tal Yael , Goldfeld Moshe , Zalatkin Tania , Livoff Alejandro , Khoury Raghad Jeris , Sgayer Inshirah , Ben-Sira Liat , Kalfon Limor , Falik-Zaccai Tzipora C. 
Published: August 2024

AbstractTAF8 is part of the transcription factor TFIID complex. TFIID is crucial for recruiting the transcription factor complex containing RNA polymerase II. TAF8 deficiency was recently reported as causing a severe neurodevelopmental disorder in eight patients. We have ascertained three Muslim Arab couples with fetal brain malformations. Clinical, imaging, pathological, biochemical, and molecular analyses were performed. Pre-natal ultrasound performed in four pregnancies revealed massive cerebellar atrophy, microcephaly, cerebral and corpus callosum (CC) anomalies. Pre-natal MRI studies of two of the affected fetuses confirmed microcephaly, small vermis, abnormal sulcation pattern with malformation, and shortening of CC. The fetuses were found to carry a novel likely pathogenic homozygous variant (c.45 + 5 G > A) of TAF8, predicted to affect splicing and presenting autosomal recessive inheritance. Post-mortem examinations confirmed the imaging studies in one fetus. Dysmorphic features including hypertelorism, wide nasal bridge, clinodactyly, and hirsutism were present. Western blotting analysis in fibroblasts of an affected fetus demonstrated a significant reduction of TAF8 protein. We determined high expression levels of TAF8 which progressively diminish in fetal brains of WT mice. We report for the first time the fetal presentation of TAF8 deficiency due to a novel genetic variant, and study TAF8 presence during fetal and neonatal periods in mouse brains. Our study may contribute to understanding the role of TAF8 in the developing human brain.
Direct capture of low-concentration CO2 and selective hydrogenation to CH4 over Al2O3-supported Ni–La dual functional materials
Authors: Tatsumichi Tomotaka , Okuno Rei , Hashimoto Hideki , Namiki Norikazu , Maeno Zen 
Published: August 2024

La-modified Al2O3-supported Ni nanoparticles were developed as effective dual functional materials for direct capture of low-concentration CO2 and selective hydrogenation to CH4 under mild reaction conditions.
Artificial Intelligence–Assisted Speech Therapy for /ɹ/: A Single-Case Experimental Study
Authors: Benway Nina R. , Preston Jonathan L. 
Published: August 2024

Purpose:
This feasibility trial describes changes in rhotic production in residual speech sound disorder following ten 40-min sessions including artificial intelligence (AI)-assisted motor-based intervention with ChainingAI, a version of Speech Motor Chaining that predicts clinician perceptual judgment using the PERCEPT-R Classifier (Perceptual Error Rating for the Clinical Evaluation of Phonetic Targets). The primary purpose is to evaluate /ɹ/ productions directly after practice with ChainingAI versus directly before ChainingAI and to evaluate how the overall AI-assisted treatment package may lead to perceptual improvement in /ɹ/ productions compared to a no-treatment baseline phase.

Method:
Five participants ages 10;7–19;3 (years;months) who were stimulable for /ɹ/ participated in a multiple (no-treatment)-baseline ABA single-case experiment. Prepractice activities were led by a human clinician, and drill-based motor learning practice was automated by ChainingAI. Study outcomes were derived from masked expert listener perceptual ratings of /ɹ/ from treated and untreated utterances recorded during baseline, treatment, and posttreatment sessions.

Results:
Listeners perceived significantly more rhoticity in practiced utterances after 30 min of ChainingAI, without a clinician, than directly before ChainingAI. Three of five participants showed significant generalization of /ɹ/ to untreated words during the treatment phase compared to the no-treatment baseline. All five participants demonstrated statistically significant generalization of /ɹ/ to untreated words from pretreatment to posttreatment. PERCEPT-clinician rater agreement (i.e., F1 score) was largely within the range of human–human agreement for four of five participants. Survey data indicated that parents and participants felt hybrid computerized–clinician service delivery could facilitate at-home practice.

Conclusions:
This study provides evidence of participant improvement for /ɹ/ in untreated words in response to an AI-assisted treatment package. The continued development of AI-assisted treatments may someday mitigate barriers precluding access to sufficiently intense speech therapy for individuals with speech sound disorders.

Supplemental Material:

https://doi.org/10.23641/asha.26662807
Das Schweizer Klauengesundheitsprojekt – eine Zwischenbilanz nach 5
Jahren
Authors: Syring Claudia , Ruiters Maria Welham , Weber Jim , Fürmann Andreas , Sarbach Analena , Steiner Adrian 
Published: August 2024

Zusammenfassung
Gegenstand und ZielDas Schweizer Klauengesundheitsprojekt (SKGP) begann am
1.1.2019 und dauert 8 Jahre. Die Hauptziele des SKGP sind (a) die digitale
Erhebung von Klauengesundheitsdaten bei Rindern in der Schweiz im Rahmen der
Klauenpflege durch 100 gewerbsmäßig arbeitende Klauenpfleger, (b) die
Erarbeitung von Klauengesundheitskonzepten, (c) die Verbesserung der
Klauengesundheit bei Rindern in der Schweiz, (d) die Erarbeitung von Zuchtwerten
für Klauengesundheit und (e) die Reduktion des Einsatzes von Antibiotika zur
Bekämpfung von Klauengesundheitsproblemen.
Material und Methoden Die Datenerhebung erfolgte digital durch 45
Klauenpfleger, welche vorgängig das Fortbildungsprogramm zur Befundung und
digitalen Dokumentation gemäß ICAR Atlas der Klauengesundheit erfolgreich
abgeschlossen hatten. Für die Datenspeicherung wurde die nationale
Tiergesundheitsdatenbank weiterentwickelt. Tierhaltungsbetrieben mit ungünstiger
Klauengesundheit wurde eine Betriebsanalyse mit anschließenden jährlichen
Betreuungsbesuchen angeboten.
Ergebnisse Bis am Ende des 5. Projektjahres sind insgesamt 1155 Tierhalter
dem Projekt beigetreten. Die Klauengesundheitsdaten von 149753 Klauenpflegen auf
Tierebene wurden gespeichert und 176 Besuche und Analysen von Betrieben mit
Klauengesundheitsproblemen durchgeführt. Ein Gesundheitskonzept für
mechanisch-metabolisch assoziierte Klauenprobleme wurde erarbeitet und
erfolgreich etabliert. Die Biosicherheitsmaßnahmen anlässlich der Klauenpflege
wurden analysiert und eine Broschüre mit Empfehlungen für Klauenpfleger
erarbeitet. Risikofaktoren für das Vorkommen von Dermatitis Digitalis in
Milchviehbetrieben wurden identifiziert. Die Prävalenz von Alarmerkrankungen ist
in den Projektjahren 2 bis 4 bei den beteiligten Betrieben signifikant
gesunken.
Schlussfolgerungen Die wissenschaftliche Projektbegleitung erwies sich als
äußerst sinnvoll, da der Projektfortschritt kontinuierlich verfolgt und neue
Fragestellungen zeitnah angegangen werden konnten. Digital erfasste Befunde
während der Betriebsklauenpflege sind essenziell für die Überwachung und
Verbesserung der Klauengesundheit.
Klinische Relevanz Die Beschreibung und kritische Beurteilung der
Vorgehensweise kann von anderen Konsortien, welche ein ähnliches Projekt planen,
genutzt werden.
Wundversorgung – ein Lehrthema mit Potenzial
Authors: Erfurt-Berge Cornelia 
Published: August 2024

ZusammenfassungDie Behandlung von Menschen mit chronischen Wunden ist Bestandteil der dermatologischen Grundversorgung. Mit zunehmendem Alter steigt die Prävalenz chronischer Wunden an und so ist auch zukünftig ein Zuwachs an Patienten zu erwarten. Gleichzeitig zeichnet sich das Thema Wundmanagement als Paradebeispiel für die interdisziplinäre und auch interprofessionelle Patientenversorgung aus und kann damit in vielen Fachdisziplinen als Unterrichtsthema aufgegriffen werden. Dem zukünftig als Hausarzt oder Hausärztin tätigen Studierenden kommt später eine Lotsenrolle zu und er muss in der Lage sein, den Patienten rechtzeitig zu den notwendigen Fachdisziplinen für Diagnostik und Therapie weiter zu verweisen. Eine chronische Wunde als Komorbidität kann in allen Fachdisziplinen auftreten und bedarf einer korrekten Basisversorgung. Die Dermatologie deckt im Bereich Wundmanagement nicht nur den phlebologischen Versorgungskreis mit ab, sondern hat gerade in der Diagnostik seltenerer Ursachen chronischer Wunden eine Schlüsselrolle. Die Indikationsstellung und Durchführung weiterführender Diagnostik wie bspw. eine histologische Untersuchung einer tiefen Gewebeprobe kann Teil einer Lerneinheit für viele dermatologische Krankheitsbilder sein, die sich mit einer Ulzeration als Symptom darstellen. Es bieten sich somit viele didaktische Möglichkeiten, das Thema in eine Lehreinheit zu integrieren. Neben kognitiven Lernzielen zur Pathophysiologie und Differenzialdiagnostik chronischer Wunden können praktische Kompetenzen wie Anlegen von Verbänden, Sonografie oder Debridementverfahren vermittelt werden. Auch affektive Lernziele können in den Bereichen Versorgung von Menschen mit chronischen Erkrankungen oder Umsetzung präventiver Maßnahmen in Lehrpläne integriert werden.
Anxiety in Endometriosis Patients: Implications for Clinical Practice
Authors: Kupec Tomas , Caspers Rebecca , Meyer-Wilmes Philipp , Najjari Laila , Stickeler Elmar , Wittenborn Julia 
Published: August 2024

AbstractEndometriosis is a chronic disease associated with pain that affects at least 10% of all women of reproductive age. The symptoms of endometriosis have a negative impact on quality of life; they limit the patient physically and psychologically and are the cause of significant anxiety. The aim of our study was to investigate the anxiety levels of women presenting to our specialized endometriosis outpatient clinic at the RWTH Aachen University Hospital. We sought to record their anxiety symptoms and investigate the effect of extensive counseling on anxiety in patients with endometriosis. We hypothesized that detailed counseling and the planning of multimodal endometriosis therapy would reduce anxiety.Data from 183 patients with lower abdominal pain or suspected endometriosis were analyzed. Prior to the examination, the patients completed a standardized anamnesis form including the German version of the STAI (State Trait Anxiety Inventory). The diagnosis of endometriosis was made in accordance with the recent ESHRE guideline and was based on anamnesis, gynecological examination, and ultrasound by a specialist senior physician with many years of experience in treating endometriosis.Prior to the medical examination, we observed a mean STAI-State score of 48.44 ± 11.56 and STAI-Trait score 45.68 ± 11.27. Following medical examination and planning of multimodal therapy, there was a significant decrease in the mean STAI-State score from 48.44 ± 11.56 to 42.43 ± 10.01 (p < 0.0001) and a minimal but significant decrease in the mean STAI-Trait score from 45.68 ± 11.27 to 45.01 ± 11.57 (p < 0.05).Our study showed that endometriosis is associated with high levels of anxiety. Detailed counseling and the planning of a multimodal therapy led to a significant improvement in anxiety levels.
Thymom bei einer jung-adulten Katze
Authors: Masche Anja , Bartels Kimberly , Mangelsdorf-Ziera Susanne , Schmerbach Kay , Gruber Achim D. , Hergt Franziska 
Published: August 2024

ZusammenfassungThymome und mediastinale Lymphome sind die häufigsten mediastinalen Neoplasien
der Katze. Während das mediastinale Lymphom vornehmlich bei jüngeren Katzen
(etwa 2 bis 4 Jahre) vorkommt, werden Thymome fast ausschließlich bei älteren
Katzen diagnostiziert. Dass das jedoch nicht zwingend immer zutrifft, zeigt der
folgende Fall.Ein 3 Jahre und 11 Monate alter, kastrierter Europäisch-Kurzhaar-Kater wurde mit
dem Vorbericht einer Belastungsintoleranz und erschwerter Atmung vorgestellt.
Beide Symptome traten vor allem bei hoher Umgebungstemperatur auf.
Röntgenologisch zeigte sich eine mediastinale Masse, die die Brusthöhle zu einem
erheblichen Anteil ausfüllte. Es wurde eine computertomografische Untersuchung
sowie eine ultraschallgestützte TruCut-Biopsie durchgeführt. Die histologische
Untersuchung ergab den Verdacht auf das Vorliegen eines Thymoms. Es erfolgte
eine sternale Thorakotomie und Resektion der Umfangsvermehrung. Die nachfolgende
histopathologische Untersuchung bestätigte die Verdachtsdiagnose eines
mediastinalen Thymoms. Der Kater erholte sich postoperativ gut und wurde nach
Hause entlassen. Eine klinische und röntgenologische Kontrolluntersuchung war
nach 8 Monaten unauffällig.
Gene Mutations in Gastrointestinal Stromal Tumors: Advances in Treatment and Mechanism Research
Authors: Cao Lei , Tian Wencong , Zhao Yongjie , Song Peng , Zhao Jia , Wang Chuntao , Liu Yanhong , Fang Hong , Liu Xingqiang 
Published: August 2024

AbstractAlthough gastrointestinal stromal tumors (GISTs) has been reported in patients of all ages, its diagnosis is more common in elders. The two most common types of mutation, receptor tyrosine kinase (KIT) and platelet-derived growth factor receptor a (PDGFRA) mutations, hold about 75 and 15% of GISTs cases, respectively. Tumors without KIT or PDGFRA mutations are known as wild type (WT)-GISTs, which takes up for 15% of all cases. WT-GISTs have other genetic alterations, including mutations of the succinate dehydrogenase and serine–threonine protein kinase BRAF and neurofibromatosis type 1. Other GISTs without any of the above genetic mutations are named “quadruple WT” GISTs. More types of rare mutations are being reported. These mutations or gene fusions were initially thought to be mutually exclusive in primary GISTs, but recently it has been reported that some of these rare mutations coexist with KIT or PDGFRA mutations. The treatment and management differ according to molecular subtypes of GISTs. Especially for patients with late-stage tumors, developing a personalized chemotherapy regimen based on mutation status is of great help to improve patient survival and quality of life. At present, imatinib mesylate is an effective first-line drug for the treatment of unresectable or metastatic recurrent GISTs, but how to overcome drug resistance is still an important clinical problem. The effectiveness of other drugs is being further evaluated. The progress in the study of relevant mechanisms also provides the possibility to develop new targets or new drugs.
Therapie auf Augenhöhe fördert die Compliance – die 5 Stufen des Shared Decision
Making
Authors: Höller Thune 
Published: August 2024

ZusammenfassungDie ICF-Faktoren Aktivität und Partizipation spielen eine zentrale Rolle in der modernen Physiotherapie.
Doch wie gelingt die Partizipation innerhalb der Therapie? Tatsächlich sollten Patient*innen bereits in
der Anamnese an ihrer Rehabilitation teilhaben und Behandlungsziele selbst formulieren. Das Konzept ist
bekannt unter Shared Decision Making (SDM).
Incoherent ultrafast energy transfer in phycocyanin 620 from Thermosynechococcus vulcanus revealed by polarization-controlled two dimensional electronic spectroscopy
Authors: Wang Jiayu , Zhu Ruidan , Zou Jiading , Liu Heyuan , Meng Hanting , Zhen Zhanghe , Li Wenjun , Wang Zhuan , Chen Hailong , Pu Yang , Weng Yuxiang 
Published: August 2024

Phycocyanin 620 (PC620) is the outermost light-harvesting complex in phycobilisome of cyanobacteria, engaged in light collection and energy transfer to the core antenna, allophycocyanin. Recently, long-lived exciton–vibrational coherences have been observed in allophycocyanin, accounting for the coherent energy transfer [Zhu et al., Nat. Commun. 15, 3171 (2024)]. PC620 has a nearly identical spatial location of three α84–β84 phycocyanobilin pigment pairs to those in allophycocyanin, inferring an existence of possible coherent energy transfer pathways. However, whether PC620 undergoes coherent or incoherent energy transfer remains debated. Furthermore, accurate determination of energy transfer rates in PC620 is still necessary owing to the spectral overlap and broadening in conventional time-resolved spectroscopic measurements. In this work, the energy transfer process within PC620 was directly resolved by polarization-controlled two dimensional electronic spectroscopy (2DES) and global analysis. The results show that the energy transfer from α84 to the adjacent β84 has a lifetime constant of 400 fs, from β155 to β84 of 6–8 ps, and from β155 to α84 of 66 ps, fully conforming to the Förster resonance energy transfer mechanism. The circular dichroism spectrum also reveals that the α84–β84 pigment pair does not form excitonic dimer, and the observed oscillatory signals are confirmed to be vibrational coherence, excluding the exciton–vibrational coupling. Nodal line slope analysis of 2DES further reveals that all the vibrational modes participate in the energy dissipation of the excited states. Our results consolidate that the ultrafast energy transfer process in PC620 is incoherent, where the twisted conformation of α84 is suggested as the main cause for preventing the formation of α84–β84 excitonic dimer in contrast to allophycocyanin.
A mathematical model of animal-human Brucellosis transmission in Armenia: Implications for prevention and control
Authors: Anyanwu Uchenna , Wang Yuqian , Walker Alexandra , Dimov Artemiy , Zinsstag Jakob , Akladios Youssef , Chitnis Nakul , Volken Sandra , Li Binyu , Paronyan Lusine , Manukyan Ani , Simonyan Jon , Markosian Tigran , Hattendorf Jan 
Published: August 2024

Abstract
Brucellosis, a zoonotic disease impacting public health and economies, is prevalent in several countries, particularly low- and middle-income regions. This study centers on Armenia, where the Veterinary Department of the Food Safety Inspection Body employs a test-and-slaughter strategy to control the disease. A dynamic deterministic compartmental model was constructed using seropositive reported data from humans and livestock (cattle and sheep) from 2019 to 2021. The model simulates the effects of enhanced test-and-slaughter strategies from 2022 to 2031 on brucellosis transmission among sheep, cattle, and humans. The results suggest that an increase in testing and slaughter rates leads to a decrease in infected populations among both humans and livestock. Approximately 65% of the human brucellosis cases are a result of sheep-to-human transmissions. This reduction in infected populations is expected to subsequently lower the overall transmission rates in livestock and humans. However, even with the highest coverage levels (75% for sheep and 90% for cattle), infections in humans and livestock are projected to persist. The study highlights the need for a One Health approach that integrates mathematical modeling with public health intervention strategies. While the upgraded test-and-slaughter strategy could prove effective, an economic analysis of the predicted cumulative incidence in humans and livestock prevalence could guide decision making processes. Compensation for culled animals is a critical factor. The success of the intervention relies on collaboration between veterinary and public health sectors, community engagement, and awareness campaigns.

One Health impact statement
This study applied a mathematical model to investigate brucellosis transmission within the livestock population and from animals to humans. It assessed the impact of different test-and-slaughter coverage levels from 2022 to 2031 on disease burden and livestock populations. Although the research did not encompass the entire One Health spectrum, it shed light on the potential benefits of integrating human and animal health interventions. Local institutions (such as the Food Safety and Inspectorate Body and the National Centre for Disease Control in Armenia) and international collaboration among scientists contributed to a better understanding and controlling zoonotic diseases. The findings offer valuable insights for decision making, aiding Armenian policy makers in effectively managing brucellosis and enhancing public health, food safety, and monetary savings. Furthermore, the research provides a basis for further exploration in this field.