bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uniqueness of the Gossypium mustelinum Genome Revealed by GISH and 45S rDNA FISH
Authors: Wu Qiong , Liu Fang , Li Shaohui , Song Guoli , Wang Chunying , Zhang Xiangdi , Wang Yuhong , Stelly David , Wang Kunbo 
Published: June 2013

AbstractGossypium mustelinum ((AD)4) is one of five disomic species in Gossypium. Three 45S ribosomal DNA (rDNA) loci were detected in (AD)4 with 45S rDNA as probe, and three pairs of brighter signals were detected with genomic DNA (gDNA) of Gossypium D genome species as probes. The size and the location of these brighter signals were the same as those detected with 45S rDNA as probe, and were named GISH‐NOR. One of them was super‐major, which accounted for the fact that about one‐half of its chromosome at metaphase was located at chromosome 3, and other two were minor and located at chromosomes 5 and 9, respectively. All GISH‐NORs were located in A sub‐genome chromosomes, separate from the other four allopolyploid cotton species. GISH‐NOR were detected with D genome species as probe, but not A. The greatly abnormal sizes and sites of (AD)4 NORs or GISH‐NORs indicate a possible mechanism for 45S rDNA diversification following (AD)4 speciation. Comparisons of GISH intensities and GISH‐NOR production with gDNA probes between A and D genomes show that the better relationship of (AD)4 is with A genome. The shortest two chromosomes of A sub‐genome of G. mustelinum were shorter than the longest chromosome of D sub‐genome chromosomes. Therefore, the longest 13 chromosomes of tetraploid cotton being classified as A sub‐genome, while the shorter 13 chromosomes being classified as D sub‐genome in traditional cytogenetic and karyotype analyses may not be entirely correct.
Virtual Histology Intravascular Ultrasound Analysis of Attenuated Plaque and Ulcerated Plaque Detected by Gray Scale Intravascular Ultrasound and the Relation Between the Plaque Composition and Slow Flow/No Reflow Phenomenon During Percutaneous Coronary Intervention
Authors: AMANO HIDEO , WAGATSUMA KENJI , YAMAZAKI JYUNICHI , IKEDA TAKANORI 
Published: June 2013

AbstractObjectiveThis study aimed to assess the plaque characteristics of attenuated and ulcerated plaques in virtual‐histology intravascular ultrasound (VH‐IVUS) and the incidence of slow flow/no reflow during percutaneous coronary intervention (PCI).BackgroundThe attenuated and ulcerated plaques are thought as embolic prone plaque; however, the plaque characteristics are unclear.MethodsSubjects were 119 patient's 121 lesions undergoing VH‐IVUS before coronary stenting. These lesions were divided into the 15 lesions showing attenuated plaque, 24 lesions showing ulcerated plaque, and 82 lesions revealing neither attenuated nor ulcerated plaque (the control group).ResultsFibro‐fatty tissue in the attenuation group was significantly larger than the control group (27.5 ± 9.5% vs 13.9 ± 8.2%, P < 0.01, 3.5 ± 1.9 mm2 vs 1.6 ± 1.2 mm2, P < 0.01). Necrotic core in ulceration group was significantly larger than the control group (20.7 ± 9.0% vs 15.9 ± 9.0%, P < 0.05, 2.5 ± 1.3 mm2 vs 1.7 ± 1.0 mm2, P < 0.01). Dense calcium in ulceration group was significantly larger than the control group (12.3 ± 6.4% vs 8.3 ± 7.1%, P < 0.05, 1.4 ± 0.7 mm2 vs 0.9 ± 0.8 mm2, P < 0.01). In the ulceration group, the necrotic core area of acute coronary syndrome was significantly larger than the stable angina pectoris (3.0 ± 1.4 mm2 vs 1.8 ± 1.0 mm2, P < 0.05). The incidence of slow flow/no reflow was significantly higher in the attenuation and ulceration group than the control group (20.0% [3/15], 20.8% [4/24] vs 4.9% [4/82], P < 0.05, 0.05).ConclusionThe attenuated plaque had significantly larger fibro‐fatty tissue. The ulcerated plaque had significantly larger necrotic core and dense calcium. The lesions with the attenuated and the ulcerated plaque had more frequent slow flow/no reflow during PCI. (J Interven Cardiol 2013;26:295–301)
Guilty, But Not Ashamed: “True” Self‐Conceptions Influence Affective Responses to Personal Shortcomings
Authors: Vess Matthew , Schlegel Rebecca J. , Hicks Joshua A. , Arndt Jamie 
Published: June 2013

AbstractThe current research examined how true self‐conceptions (who a person believes he or she truly is) influence negative self‐relevant emotions in response to shortcomings. In Study 1 (N = 83), an Internet sample of adults completed a measure of authenticity, reflected on a shortcoming or positive life event, and completed state shame and guilt measures. In Study 2 (N = 49), undergraduates focused on true versus other determined self‐attributes, received negative performance feedback, and completed state shame and guilt measures. In Study 3 (N = 138), undergraduates focused on self‐determined versus other determined self‐aspects, reflected on a shortcoming or neutral event, and completed state shame, guilt, and self‐esteem measures. In Study 4 (N = 75), undergraduates thought about true self‐attributes, an achievement, or an ordinary event; received positive or negative performance feedback; and completed state shame and guilt measures. In Study 1, differences in true self‐expression positively predicted shame‐free guilt (but not guilt‐free shame) following reminders of a shortcoming. Studies 2–4 found that experimental activation of true self‐conceptions increased shame‐free guilt and generally decreased guilt‐free shame in response to negative evaluative experiences. The findings offer novel insights into true self‐conceptions by revealing their impact on negative self‐conscious emotions.
Source Personality and Persuasiveness: Big Five Predispositions to Being Persuasive and the Role of Message Involvement
Authors: Oreg Shaul , Sverdlik Noga 
Published: June 2013

AbstractIn the present studies we incorporate a Person × Situation perspective into the study of the persuasion source. Specifically, we aimed to identify the personality characteristics of the persuasive individual and test the moderating role of target and source involvement. In three studies we found support for hypothesized relationships between source persuasiveness and Extraversion, Neuroticism, and Openness to Experience, and evidence for a moderating effect of involvement. In a preliminary study (N = 66, Mage = 22.7, 64% female), we demonstrated expected differences in the personality ratings assigned to a hypothetical persuasive versus nonpersuasive individual. In Study 1 (N = 95, Mage = 24.1, 62% female), through sets of two‐person debates, we showed that source Extraversion and Openness to Experience were positively, and Neuroticism negatively, associated with source persuasiveness. In Study 2 (N = 148, Mage = 24.3, 61% female), we manipulated the level of involvement and mostly replicated the results from Study 1, but, corresponding with our predictions, only when involvement was low. Our findings demonstrate the relevance of an interactionist approach to the study of persuasion, highlighting the role of personality in the study of the persuasion source.
Melatonin ameliorates Angiotensin II‐induced vascular endothelial damage via its antioxidative properties
Authors: Nakao Tomoko , Morita Hiroyuki , Maemura Koji , Amiya Eisuke , Inajima Tsukasa , Saito Yuichiro , Watanabe Masafumi , Manabe Ichiro , Kurabayashi Masahiko , Nagai Ryozo , Komuro Issei 
Published: June 2013

AbstractMelatonin is well known to have a beneficial effect on the cardiovascular system, but it remains to be elucidated whether melatonin has a therapeutic effect on the vascular damage induced by the potential vasoactive substance angiotensin II (Ang II). In this study, the effects of melatonin on Ang II‐induced vascular endothelial damage were investigated. In cultured vascular endothelial cells, Ang II stimulation increased ROS generation and inhibited eNOS phosphorylation (Ser1177), both of which were clearly restored by pretreatment with melatonin. The translocation of p47phox subunit of NADPH oxidase from the cytosol to plasma membrane was promoted in Ang II‐treated vascular endothelial cells, which was canceled by melatonin pretreatment. In Ang II‐infused rats, increased ROS generation in the aortic wall and impaired endothelial function of the aortic ring were observed, which were rescued by coadministration of melatonin. In vasculature, melatonin receptor agonist ramelteon had the antioxidative effect in the same manner as melatonin by itself. These findings suggest that melatonin directly ameliorates Ang II‐induced vascular endothelial damage partly via its antioxidative properties, providing with us the potential rationale for clinical application of melatonin to the prevention from cardiovascular diseases.
Melatonin inhibits visfatin‐induced inducible nitric oxide synthase expression and nitric oxide production in macrophages
Authors: Kang Young‐Soon , Kang Yong‐Gyu , Park Hyun‐Joo , Wee Hee‐Jun , Jang Hye‐Ock , Bae Moon‐Kyoung , Bae Soo‐Kyung 
Published: June 2013

AbstractAberrant expression of inducible nitric oxide synthase (iNOS) in macrophages, which has been reported to be suppressed by melatonin, has an important contribution in the development of pathological inflammation. Visfatin, an adipokine, regulates the expression of various inflammatory factors, leading to inflammation; however, the influence of visfatin on iNOS‐driven processes in macrophages is unclear. Here, we report the assessment of the role of visfatin in the regulation of iNOS gene expression in macrophages. Our data show that the levels of iNOS protein in peritoneal macrophages as well as nitric oxide (NO) in blood plasma were significantly lower after lipopolysaccharide treatment in visfatin+/− mice than those in the WT mice. In addition, visfatin increases iNOS mRNA and protein levels in RAW 264.7 cells, along with increasing production of NO. The enhancement of iNOS expression was prevented by treating the cells with inhibitors of the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3), nuclear factor (NF)‐κB, extracellular signal–regulated kinase 1/2, and c‐Jun N‐terminal kinase pathways. Our results also show that visfatin‐induced iNOS expression and NO production were significantly inhibited by melatonin, an effect that was closely associated with a reduction in phosphorylated JAK2/STAT3 levels and with the inhibition of p65 translocation into nucleus. In conclusion, our data show, for the first time, that melatonin suppresses visfatin‐induced iNOS upregulation in macrophages by inhibiting the STAT3 and NF‐κB pathways. Moreover, our data suggest that melatonin could be therapeutically useful for attenuating the development of visfatin–iNOS axis‐associated diseases.
Personal beliefs, learned resourcefulness, and adaptive functioning in depressed adults
Authors: Lai C. Y. , Zauszniewski J. A. , Tang T‐C. , Hou S‐Y. , Su S‐F. , Lai P. Y. 
Published: June 2013

Accessible summary
Learned resourcefulness and personal beliefs are significant predictors of adaptive functioning.
The mediating effect of personal beliefs on the relationship between learned resourcefulness and adaptive functioning was validated in adults with depression.
The findings from this study may provide the basis for developing a useful nursing intervention constituting resourcefulness skills with positive personal beliefs to help patients with depression improve their ability to function well in their daily activities.
AbstractResearch has shown that patients with depression have difficulty with performing daily tasks and meeting their own personal care needs. According to Beck's cognitive theory of depression, such deficits in adaptive functioning are affected by disturbances in specific personal beliefs that reflect the process of regulating cognitions. Rosenbaum's learned resourcefulness theory proposed that adaptive functioning is influenced by learned resourcefulness, while learned resourcefulness is associated with the process regulating cognitions. This study aims to test the mediating effect of personal beliefs on the relationship between resourcefulness and adaptive functioning. The study involved a cross‐sectional design. Participants consisted of 187 adults with depression in southern Taiwan. The data were collected through four instruments: Cognitive Triad Inventory, Self‐Control Schedule, modified Community Living Skills Scale, and a demographic questionnaire. Both resourcefulness and personal beliefs were significant predictors of adaptive functioning, and personal beliefs mediated the effect of learned resourcefulness on the adaptive functioning of the adults with depression. The results validate the role played by personal beliefs in effecting learned resourcefulness and adaptive functioning among adults with depression and provide direction for designing nursing interventions that consider personal beliefs when teaching resourcefulness skills to adults with depression.
Perceptions of parents and children regarding asthma management responsibilities
Authors: Ekim Ayfer , Ocakci Ayse Ferda 
Published: June 2013

AbstractPurposeThe purpose of this study was to examine perceptions of children and parents regarding shared responsibilities for asthma management.Design and MethodsThe study included 72 children with asthma who were between the ages of 7 and 12 years and their parents. Asthma management responsibilities were assessed by the “Asthma Responsibility Questionnaire.”ResultsDisagreements occurred between parents and children on assuming responsibility. Children reported higher asthma management responsibility scores than reported by parents for them.Practice ImplicationsIt is important that nurses provide education and counseling to both children and their families to ensure that children take responsibility for disease management.
Commodity price shocks and inflation in a net oil‐importing economy
Authors: Misati Roseline Nyakerario , Nyamongo Esman Morekwa , Mwangi Isaac 
Published: June 2013

AbstractThe global economy experienced sharp spikes in food and oil prices in 2008–2009 and 2011 period. Oil prices and food price shocks are believed to have played a prominent role in the build‐up of persistent inflationary pressures in Kenya in the recent past. This study uses Granger causality and structural vector autoregressive (SVAR) methods to examine the dynamic linkages between commodity prices and both overall inflation and non‐food non‐fuel inflation. The study finds a significant role of oil and food prices in both measures of inflation. Specifically, the study reveals that food prices are more important than oil prices in explaining overall and non‐food non‐fuel inflation when both variables are considered in the same VAR framework. However, the effect of oil prices on inflation is more persistent than the effect of food prices. The paper also finds that the food and oil inflation effects have more significant influence on non‐food non‐fuel inflation than money supply growth rate and that oil price shocks immediately depreciate the exchange rate. Based on the results, the study recommends adoption of measures to reduce oil dependence, usage of targeted intervention rather than tax waivers during crisis periods, strengthening of supply response measures and a neutral monetary policy stance in the face of shocks unless they get entrenched in the non‐food non‐fuel inflation.
Role of co‐infection by Pectobacterium and Verticillium dahliae in the development of early dying and aerial stem rot of Russet Burbank potato
Authors: Dung J. K. S. , Johnson D. A. , Schroeder B. K. 
Published: June 2013

Potato early dying (PED) is a disease complex primarily caused by the fungus Verticillium dahliae. Pectolytic bacteria in the genus Pectobacterium can also cause PED symptoms as well as aerial stem rot (ASR) of potato. Both pathogens can be present in potato production settings, but it is not entirely clear if additive or synergistic interactions occur during co‐infection of potato. The objective of this study was to determine if co‐infection by V. dahliae and Pectobacterium results in greater PED or ASR severity using a greenhouse assay and quantitative real‐time PCR to quantify pathogen levels in planta. PED symptoms caused by Pectobacterium carotovorum subsp. carotovorum isolate Ec101 or V. dahliae isolate 653 alone included wilt, chlorosis and senescence and were nearly indistinguishable. Pectobacterium wasabiae isolate PwO405 caused ASR symptoms including water‐soaked lesions and necrosis. Greater Pectobacterium levels were detected in plants inoculated with PwO405 compared to Ec101, suggesting that ASR can result in high Pectobacterium populations in potato stems. Significant additive or synergistic effects were not observed following co‐inoculation with these strains of V. dahliae and Pectobacterium. However, infection coefficients of V. dahliae and Ec101 were higher and premature senescence was greater in plants co‐inoculated with both pathogens compared to either pathogen alone in both trials, and V. dahliae levels were greater in basal stems of plants co‐inoculated with either Pectobacterium isolate. Overall, these results indicate that although co‐infection by Pectobacterium and V. dahliae does not always result in significant additive or synergistic interactions in potato, co‐infection can increase PED severity.
Efficient Bayesian Multivariate Surface Regression
Authors: Li Feng , Villani Mattias 
Published: June 2013

ABSTRACTMethods for choosing a fixed set of knot locations in additive spline models are fairly well established in the statistical literature. The curse of dimensionality makes it nontrivial to extend these methods to nonadditive surface models, especially when there are more than a couple of covariates. We propose a multivariate Gaussian surface regression model that combines both additive splines and interactive splines, and a highly efficient Markov chain Monte Carlo algorithm that updates all the knot locations jointly. We use shrinkage prior to avoid overfitting with different estimated shrinkage factors for the additive and surface part of the model, and also different shrinkage parameters for the different response variables. Simulated data and an application to firm leverage data show that the approach is computationally efficient, and that allowing for freely estimated knot locations can offer a substantial improvement in out‐of‐sample predictive performance.
How WM Load Influences Linguistic Processing in Adults: A Computational Model of Pronoun Interpretation in Discourse
Authors: van Rij Jacolien , van Rijn Hedderik , Hendriks Petra 
Published: June 2013

AbstractThis paper presents a study of the effect of working memory load on the interpretation of pronouns in different discourse contexts: stories with and without a topic shift. We discuss a computational model (in ACT‐R, Anderson, 2007) to explain how referring expressions are acquired and used. On the basis of simulations of this model, it is predicted that WM constraints only affect adults' pronoun resolution in stories with a topic shift, but not in stories without a topic shift. This latter prediction was tested in an experiment. The results of this experiment confirm that WM load reduces adults' sensitivity to discourse cues signaling a topic shift, thus influencing their interpretation of subsequent pronouns.
The Griffithsin Dimer Is Required for High-Potency Inhibition of HIV-1: Evidence for Manipulation of the Structure of gp120 as Part of the Griffithsin Dimer Mechanism
Authors: Xue Jie , Hoorelbeke Bart , Kagiampakis Ioannis , Demeler Borries , Balzarini Jan , LiWang Patricia J. 
Published: June 2013

ABSTRACT
Griffithsin (Grft) is a protein lectin derived from red algae that tightly binds the HIV envelope protein gp120 and effectively inhibits virus infection. This inhibition is due to the binding by Grft of high-mannose saccharides on the surface of gp120. Grft has been shown to be a tight dimer, but the role of the dimer in Grft's anti-HIV function has not been fully explored. To investigate the role of the Grft dimer in anti-HIV function, an obligate dimer of Grft was designed by expressing the protein with a peptide linker between the two subunits. This “Grft-linker-Grft” is a folded protein dimer, apparently nearly identical in structural properties to the wild-type protein. A “one-armed” obligate dimer was also designed (Grft-linker-Grft OneArm), with each of the three carbohydrate binding sites of one subunit mutated while the other subunit remained intact. While both constructed dimers retained the ability to bind gp120 and the viral surface, Grft-linker-Grft OneArm was 84- to 1,010-fold less able to inhibit HIV than wild-type Grft, while Grft-linker-Grft had near-wild-type antiviral potency. Furthermore, while the wild-type protein demonstrated the ability to alter the structure of gp120 by exposing the CD4 binding site, Grft-linker-Grft OneArm largely lost this ability. In experiments to investigate gp120 shedding, it was found that Grft has different effects on gp120 shedding for strains from subtype B and subtype C, and this might correlate with Grft function. Evidence is provided that the dimer form of Grft is critical to the function of this protein in HIV inhibition.
Klebsiella pneumoniae Sequence Type 11 from Companion Animals Bearing ArmA Methyltransferase, DHA-1 β-Lactamase, and QnrB4
Authors: Hidalgo Laura , Gutierrez Belen , Ovejero Cristina M. , Carrilero Laura , Matrat Stephanie , Saba Courage K. S. , Santos-Lopez Alfonso , Thomas-Lopez Daniel , Hoefer Andreas , Suarez Monica , Santurde Gloria , Martin-Espada Carmen , Gonzalez-Zorn Bruno 
Published: June 2013

ABSTRACT

Seven
Klebsiella pneumoniae
isolates from dogs and cats in Spain were found to be highly resistant to aminoglycosides, and ArmA methyltransferase was responsible for this phenotype. All isolates were typed by multilocus sequence typing (MLST) as ST11, a human epidemic clone reported worldwide and associated with, among others, OXA-48 and NDM carbapenemases. In the seven strains,
armA
was borne by an IncR plasmid, pB1025, of 50 kb. The isolates were found to coproduce DHA-1 and SHV-11 β-lactamases, as well as the QnrB4 resistance determinant. This first report of the ArmA methyltransferase in pets illustrates their importance as a reservoir for human multidrug-resistant
K. pneumoniae
.
CTX-M-123, a Novel Hybrid of the CTX-M-1 and CTX-M-9 Group β-Lactamases Recovered from Escherichia coli Isolates in China
Authors: He Dandan , Partridge Sally R. , Shen Jianzhong , Zeng Zhenling , Liu Lanping , Rao Lili , Lv Luchao , Liu Jian-Hua 
Published: June 2013

ABSTRACT

The chimeric
bla
CTX-M-123
gene was identified in two ceftazidime-resistant
Escherichia coli
isolates from animals in different Chinese provinces. Like other CTX-M-1/9 group hybrids (CTX-M-64 and CTX-M-132), the ends (amino acids 1 to 135 and 234 to 291) of CTX-M-123 match CTX-M-15 while the central part (122 to 241) matches CTX-M-14.
bla
CTX-M-123
is carried on related, but not identical, ∼90-kb IncI1 plasmids in the two isolates, and one isolate simultaneously carries the group 1
bla
CTX-M-55
gene on an additional IncI2 plasmid.