bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time‐course of vascular dysfunction of brachial artery after transradial access for coronary angiography
Authors: Munoz‐Mendoza Jerson , Ghatak Abhijit , Pinto Miranda Veronica , Bahadu Shaka , De Marchena Eduardo , Ferreira Alexandre C. , Mendoza Cesar E. 
Published: June 2015

BackgroundPrior studies have demonstrated endothelial and smooth muscle brachial artery dysfunction after transradial cardiac catheterization for diagnostic coronary angiography. The duration of this vascular dysfunction is unknown.ObjectiveTo determine the time‐course of endothelial and smooth muscle cell dysfunction in the upstream brachial artery after transradial cardiac catheterization.MethodsWe studied 22 consecutive patients with suspected coronary artery disease (age 64.4 ± 7.7 years) undergoing diagnostic transradial cardiac catheterization. Using high‐resolution vascular ultrasound, we measured ipsilateral brachial artery diameter changes during reactive hyperemia (endothelium‐dependent dilatation) and administration of sublingual nitroglycerin (endothelium‐independent dilatation). The measurements were taken at baseline (before cardiac catheterization), 6 h, 24 h, 1 week, and 1 month postprocedure. The contralateral brachial artery served as a control.ResultsIpsilateral brachial artery diameter during endothelium‐dependent dilatation decreased significantly compared with the contralateral diameters at 6 h and 24 h after transradial cardiac catheterization (3.22 vs. 4.11 and 3.29 vs. 4.11, respectively, P < 0.001). The administration of nitroglycerin did not affect this difference. At 1 week and 1 month postprocedure there was no significant difference in diameter of the ipsilateral versus the contralateral brachial artery. As expected the contralateral brachial artery showed no significant changes in diameter.ConclusionOur results showed that transradial cardiac catheterization causes transient vascular endothelial and smooth muscle dysfunction of the ipsilateral brachial artery, which resolves within 1 week postprocedure. These findings strongly suggest the absence of systemic vascular dysfunction after transradial catheterization both immediately postprocedure as well as 1 week postprocedure. © 2015 Wiley Periodicals, Inc.
Non‐Flat Bisbenzylisoquinoline Alkaloid Fangchinoline As a Class of Potent G‐Quadruplex Stabilizer with Anti‐cancer Activity
Authors: Li Qian , Xiang Junfeng , Tang Yalin 
Published: June 2015

AbstractCompounds selectively binding and stabilizing G‐quadruplex structures could inhibit the telomerase or down‐ regulate the oncogenes and may act as anti‐cancer drugs. An alkaloid with non‐flat structure, fangchinoline, showed to strongly stabilize the intermolecular and intramolecular parallel stranded G‐quadruplex structure, increasing melting temperature by 20 and 23°C, respectively. The binding mode was investigated by using NMR and molecular modelling methods. Four human cell lines (HL‐60, BGC‐823, Bel‐7402 and KB) were taken to test the anti‐proliferation effects of fangchinoline and the IC50 values were ranged from 16 to 32 µmol/L. These results showed that the fangchinoline or related moiety derivatives may represent a class of telomere‐targeted agents as potential anti‐cancer drugs.
Spatially Interlinked Graphene with Uniformly Loaded Sulfur for High Performance Li‐S Batteries
Authors: Liu Donghai , Zhang Chen , Lv Xiaohui , Zheng Xiaoyu , Zhang Lei , Zhi Linjie , Yang Quan‐Hong 
Published: June 2015

AbstractLithium‐sulfur (Li‐S) batteries have drawn extensive attentions due to their high energy density, environmental friendliness and low cost. In this study, three‐dimensional (3D) graphene/S hybrid (G/S) is prepared by a one‐pot hydrothermal method together with redox reaction between S‐based compound and graphene oxide (GO). G/S has a three dimensional porous structure, where graphene is interconnected with each other forming a 3D conductive network. It demonstrates that the pore structure of G/S can be well controlled by optimizing the drying method of the 3D graphene‐based materials. Freeze drying and evaporation‐induced drying can induce different density and pore structure of G/S. Electrochemical tests illustrate that the resulting hybrid can deliver a specific capacity of 891 mAh·g−1 and 575 mAh·g−1 for the 1st and 100th cycle at a current density of 500 mAh·g−1.
Ruthenium Trichloride Catalyzed Highly Efficient Deoximation of Oximes to the Carbonyl Compounds and Nitriles without Acceptors
Authors: Liu Yuxiao , Yang Na , Chu Changhu , Liu Renhua 
Published: June 2015

AbstractAn acceptor‐free catalysis protocol for the deoximation of ketoximes and aldoximes using RuCl3 as the catalyst has been developed. Under the optimized conditions, various oximes were converted to ketones and nitriles with excellent isolated yields.
Rhodamine B removal using polyaniline‐supported zero‐valent iron powder in the presence of dissolved oxygen
Authors: Guo Weilin , Hao Feifei , Yue Xinxin , Liu Zhonghua , Zhang Qiying , Li Xianghui , Wei Jing 
Published: June 2015

In this study, the PANI‐supported nanoscale zero‐valent iron (PANI/nZVI) composites have been successfully synthesized to remove Rhodamine B (RhB) from aqueous solutions using a heterogeneous Fenton‐like system. The synthetic PANI/nZVI composites were characterized using X‐ray diffraction (XRD), Transmission electron microscope (TEM) and Fourier transform infrared (FTIR). The results showed that they were lamellar structures and nZVI nanoparticles were introduced into their structures. The performances of PANI/nZVI composites on the activation of molecular oxygen for removal of RhB were investigated and the effects of operating parameters, such as PANI/nZVI dosage, PANI and nZVI mass ratio, RhB initial concentration, and pH value on RhB removal were also discussed. The results indicate that PANI/nZVI was proved to be the most efficient in that more than 83.31% of RhB was removed, whereas only 11.15% when using nZVI after reacting for 120 min with an initial RhB concentration of 0.02 mmol L−1 (pH = 6.50). Furthermore, the reaction mechanism was discussed by measuring the concentrations of Fe(II), total Fe and H2O2 formed in the system and examining scavenging effects using copper chloride and methanol. Finally, the stability of PANI/nZVI nanocatalyst was studied. © 2015 American Institute of Chemical Engineers Environ Prog, 35: 48–55, 2016
Experimental Study of Internal Reforming on Large‐area Anode Supported Solid Oxide Fuel Cells
Authors: Lim H.‐T. , Yang C. , Hwang S. C. , Choi Y.‐J. 
Published: June 2015

AbstractThe effect of endothermic internal steam reformation of methane and exothermic fuel cell reaction on the temperature of a planar‐type anode‐supported solid oxide fuel cell was experimentally investigated as a function of current density and fuel utilization. We fabricated a large‐area (22 × 33 cm2) cell and compared temperature profiles along the cell using 30 thermocouples inserted through the cathode end plate at 750 °C under various conditions (Uf ∼50% at 0.4 A cm−2; Uf ∼70% at 0.4 A cm−2; Uf ∼50% at 0.2 A cm−2) with hydrogen fuel and methane‐steam internal reforming. The endothermic effect due to internal reforming mainly occurs at the gas inlet region, so this process is not very effective to cool down the hot spot created by the exothermic fuel cell reaction. This eventually results in a larger temperature difference on the cell. The most moderate condition with regards to thermal gradient on the cell corresponds to high fuel utilization (Uf ∼70%) and low current density (∼0.2 A cm−2). The electrochemical performance was also measured, and it was found that the current–voltage characteristics are comparable for the cell operated under hydrogen fuel and internal steam reforming of methane because of lower polarization resistance with high partial pressure of water vapor.
π‐Excess Aromatic σ2P Ligands: Formation of a Heterocyclic 1,2‐Diphosphine by the Addition of tBuLi and Subsequent Inverse Addition of the Product at the P=C Bonds of Two Molecules of 1‐Neopentyl‐1,3‐benzazaphosphole
Authors: Aluri Bhaskar R. , Ghalib Mohammed , Kindermann Markus K. , Jones Peter G. , Heinicke Joachim W. 
Published: June 2015

ABSTRACTThe reactivity of tBuLi (pentane) toward the N‐neopentyl‐substituted π‐excess P=CH–N heterocycle 1 depends on the solvent (tetrahydrofuran, diethyl ether, hexane, and toluene) and reaction conditions. Trapping of the resulting organolithium compounds with CO2/ClSiMe3, ClSiMe3, or EtI led to various products indicating CH lithiation (1a,b), normal addition of tBuLi at the P=C bond (E/Z‐2a,b), inverse addition of the primary addition product 2Li at the P=C bond of a second molecule 1, affording 3‐tert‐butyl‐2,2’‐bis(1,3‐benzazaphospholines) 3, or inverse addition of tBuLi (4b,c). The formation of 3 demonstrates a novel route to asymmetric heterocyclic 1,2‐diphosphine ligands. The structure elucidation of the new compounds is based on their 31P and 13C NMR data with conclusive chemical shifts and P–C coupling constants, that of the isolated PH‐functionalized diphosphine 3 on crystal structure analysis.
Low CD23 expression correlates with high CD38 expression and the presence of trisomy 12 in CLL
Authors: Kriston Csilla , Bödör Csaba , Szenthe Kálmán , Bánáti Ferenc , Bánkuti Barbara , Csernus Balázs , Reiniger Lilla , Csomor Judit , Matolcsy András , Barna Gábor 
Published: June 2015

AbstractChronic lymphocytic leukemia (CLL) is characterized by a neoplastic B‐cell population coexpressing CD5 and CD23; however, the expression of CD23 is variable. In human, two isotypes of CD23 have been identified and related to different functions. The aim of our study was to investigate the relative expression of the two CD23 isotypes in CLL and find possible correlation with other prognostic factors. The expression of CD23 isotypes was analyzed in 54 cases of CLL by polymerase chain reaction (PCR) and quantitative real‐time PCR. The immunophenotype of CLL cells was characterized by flow cytometry. We demonstrated a higher CD23a than CD23b expression of CLL cells. Our results also revealed two subsets of CLL cases with a distinct CD23 isotype expression pattern. Thirty‐two percent of the cases (group CLL1) showed both low mRNA level of CD23 isotypes and high protein levels of CD20 and CD38 in contrast to group CLL2 with high CD23 mRNA levels. By correlating these results to the presence of prognostic factors determined by fluorescence in situ hybridization, we found that the majority of the cases of group CLL1 (14/17) carried trisomy 12. In summary, our results confirm a high CD23a/CD23b ratio of the CLL cells and demonstrate that in a subset of CLL cases, low CD23 expression together with high CD20 and CD38 expressions may serve as a surrogate for trisomy 12. Copyright © 2015 John Wiley & Sons, Ltd.
Cyclic mechanical stimulation rescues achilles tendon from degeneration in a bioreactor system
Authors: Wang Tao , Lin Zhen , Ni Ming , Thien Christine , Day Robert E. , Gardiner Bruce , Rubenson Jonas , Kirk Thomas B. , Smith David W. , Wang Allan , Lloyd David G. , Wang Yan , Zheng Qiujian , Zheng Ming H. 
Published: June 2015

ABSTRACTPhysiotherapy is one of the effective treatments for tendinopathy, whereby symptoms are relieved by changing the biomechanical environment of the pathological tendon. However, the underlying mechanism remains unclear. In this study, we first established a model of progressive tendinopathy‐like degeneration in the rabbit Achilles. Following ex vivo loading deprivation culture in a bioreactor system for 6 and 12 days, tendons exhibited progressive degenerative changes, abnormal collagen type III production, increased cell apoptosis, and weakened mechanical properties. When intervention was applied at day 7 for another 6 days by using cyclic tensile mechanical stimulation (6% strain, 0.25 Hz, 8 h/day) in a bioreactor, the pathological changes and mechanical properties were almost restored to levels seen in healthy tendon. Our results indicated that a proper biomechanical environment was able to rescue early‐stage pathological changes by increased collagen type I production, decreased collagen degradation and cell apoptosis. The ex vivo model developed in this study allows systematic study on the effect of mechanical stimulation on tendon biology. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1888–1896, 2015.
A Lateglacial archaeological site in the far north‐west of Europe at Rubha Port an t‐Seilich, Isle of Islay, western Scotland: Ahrensburgian‐style artefacts, absolute dating and geoarchaeology
Authors: MITHEN STEVEN , WICKS KAREN , PIRIE ANNE , RIEDE FELIX , LANE CHRISTINE , BANERJEA ROWENA , CULLEN VICTORIA , GITTINS MATTHEW , PANKHURST NICHOLAS 
Published: June 2015

ABSTRACTThe exact pattern, process and timing of the human re‐colonization of northern Europe after the end of the last Ice Age remain controversial. Recent research has provided increasingly early dates for at least pioneer explorations of latitudes above 54°N in many regions, yet the far north‐west of the European landmass, Scotland, has remained an unexplained exception to this pattern. Although the recently described Hamburgian artefacts from Howburn and an assemblage belonging to the arch‐backed point complex from Kilmelfort Cave have established at least a sporadic human presence during earlier stages of the Lateglacial Interstadial, we currently lack evidence for Younger Dryas/Greenland Stadial 1 (GS‐1) activity other than rare stray finds that have been claimed to be of Ahrensburgian affiliation but are difficult to interpret in isolation. We here report the discovery of chipped stone artefacts with technological and typological characteristics similar to those of the continental Ahrensburgian at a locality in western Scotland. A preliminary analysis of associated tephra, pollen and phytoliths, along with microstratigraphic analysis, suggest the artefacts represent one or more episodes of human activity that fall within the second half of GS‐1 and the Preboreal period. © 2015 The Authors. Journal of Quaternary Science published by John Wiley & Sons, Ltd.
Simple and Precise Quantification of Iron Catalyst Content in Carbon Nanotubes Using UV/Visible Spectroscopy
Authors: Agustina Elsye , Goak Jeungchoon , Lee Suntae , Seo Youngho , Park Jun‐Young , Lee Naesung 
Published: June 2015

AbstractIron catalysts have been used widely for the mass production of carbon nanotubes (CNTs) with high yield. In this study, UV/visible spectroscopy was used to determine the Fe catalyst content in CNTs using a colorimetric technique. Fe ions in solution form red–orange complexes with 1,10‐phenanthroline, producing an absorption peak at λ=510 nm, the intensity of which is proportional to the solution Fe concentration. A series of standard Fe solutions were formulated to establish the relationship between optical absorbance and Fe concentration. Many Fe catalysts were microscopically observed to be encased by graphitic layers, thus preventing their extraction. Fe catalyst dissolution from CNTs was investigated with various single and mixed acids, and Fe concentration was found to be highest with CNTs being held at reflux in HClO4/HNO3 and H2SO4/HNO3 mixtures. This novel colorimetric method to measure Fe concentrations by UV/Vis spectroscopy was validated by inductively coupled plasma optical emission spectroscopy, indicating its reliability and applicability to asses Fe content in CNTs.
Participation in Physical Activity, Fitness, and Risk for Obesity in Children with Developmental Coordination Disorder: A Cross‐cultural Study
Authors: Cermak S. A. , Katz N. , Weintraub N. , Steinhart S. , Raz‐Silbiger S. , Munoz M. , Lifshitz N. 
Published: June 2015

AbstractDecreased physical activity has been linked to poor fitness and obesity, resulting in increased risk for health concerns. The objective is to study the relationships between children's motor coordination and their physical activity, sedentary behaviour, fitness and weight status in a cross‐cultural study in the United States and Israel. Participants included 118 children 6–11 years of age: 53 children with developmental coordination disorder (DCD) and 65 typical children. The US sample included 31 DCD children and 44 typical children. The Israeli sample included 22 DCD children and 21 typical children. Participants were assessed on Movement Assessment Battery for Children 2, strength test of the Bruininks–Oseretsky Test of Motor Proficiency 2 and Six‐minute Walk Test and wore an accelerometer. Parents completed physical activity questionnaires and demographic information. Body mass index was calculated based on height and weight. Testing took place in two sessions. Findings are that in both Israel and the United States, children with DCD demonstrated significantly reduced physical activity, increased sedentary behaviour, poorer fitness and increased overweight compared with typical children. No significant differences were found for country. With relevance to clinical practice, fitness and obesity are major concerns for children with DCD in both countries. Inclusion of occupational therapy in health promotion for this population is critical. Additional studies with testers blind to group, larger samples and other countries are recommended. Copyright © 2015 John Wiley & Sons, Ltd.
Many private mutations originate from the first few divisions of a human colorectal adenoma
Authors: Kang Haeyoun , Salomon Matthew P , Sottoriva Andrea , Zhao Junsong , Toy Morgan , Press Michael F , Curtis Christina , Marjoram Paul , Siegmund Kimberly , Shibata Darryl 
Published: June 2015

AbstractIntratumoural mutational heterogeneity (ITH) or the presence of different private mutations in different parts of the same tumour is commonly observed in human tumours. The mechanisms generating such ITH are uncertain. Here we find that ITH can be remarkably well structured by measuring point mutations, chromosome copy numbers, and DNA passenger methylation from opposite sides and individual glands of a 6 cm human colorectal adenoma. ITH was present between tumour sides and individual glands, but the private mutations were side‐specific and subdivided the adenoma into two major subclones. Furthermore, ITH disappeared within individual glands because the glands were clonal populations composed of cells with identical mutant genotypes. Despite mutation clonality, the glands were relatively old, diverse populations when their individual cells were compared for passenger methylation and by FISH. These observations can be organized into an expanding star‐like ancestral tree with co‐clonal expansion, where many private mutations and multiple related clones arise during the first few divisions. As a consequence, most detectable mutational ITH in the final tumour originates from the first few divisions. Much of the early history of a tumour, especially the first few divisions, may be embedded within the detectable ITH of tumour genomes. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Randomized psychosocial interventions for breast cancer: impact on life purpose
Authors: Mens Maria G. , Helgeson Vicki S. , Lembersky Barry C. , Baum Andrew , Scheier Michael F. 
Published: June 2015

AbstractObjectiveThe present study sought to identify mediators underlying the effects of an education and a peer support intervention for women with breast cancer and to determine if the efficacy of a peer support intervention is moderated by cancer severity.MethodsParticipants included 180 patients with early stage (I or II) and 65 patients with late stage (IV) breast cancer. The study was originally planned as a 2 (early stage, late stage) × 3 (education intervention, peer support intervention, control condition) design; however, the education condition for the late stage cancer group was dropped, because of slow recruitment. Participants completed measures of well‐being prior to being randomized (Time 1), then again 2 weeks after the group meetings ended (Time 2), and 6 months later (Time 3).ResultsAmong the participants who had attended at least one group meeting, the education intervention predicted more life purpose and marginally predicted more perceived physical health at Time 2. The peer support intervention predicted more life purpose and less depressive symptoms at Time 2. Cancer severity did not moderate these effects. The effect of the peer support intervention on depressive symptoms was mediated by life purpose. None of the intervention effects were evident at Time 3.ConclusionsPeer support interventions have positive short‐term effects on well‐being, among women with late and early stage breast cancer, and these effects are partially mediated by changes in life purpose. Education interventions have positive short‐term effects on well‐being among women with early stage breast cancer. Copyright © 2015 John Wiley & Sons, Ltd.
Priorities and trends in the study of proteins in eye research, 1924–2014
Authors: Semba Richard D. , Lam Maggie , Sun Kai , Zhang Pingbo , Schaumberg Debra A. , Ferrucci Luigi , Ping Peipei , Van Eyk Jennifer E. 
Published: June 2015

PurposeTo identify the proteins that are relevant to eye research and develop assays for the study of a set of these proteins.Experimental designWe conducted a bibliometric analysis by merging gene lists for human and mouse from the National Center for Biotechnology Information FTP site and combining them with PubMed references that were retrieved with the search terms “eye” [MeSH Terms] OR “eye” [All Fields] OR “eyes” [All Fields].ResultsFor human and mouse eye studies, respectively, the total number of publications was 13 525 and 23 895 and the total number of proteins was 4050 and 4717. For proteins in human and mouse eye studies, respectively, 88.7 and 81.7% had five or fewer citations. The top 50 most intensively studied proteins for human and mouse eye studies were generally in the areas of photoreceptors and phototransduction, inflammation, and angiogenesis, neurodevelopment, lens transparency, and cell‐cycle and cellular processes. We proposed selected reaction monitoring assays that were developed in silico for the top fifty most intensively studied proteins in human and mouse eye research.Conclusions and clinical relevanceWe conclude that scientists engaged in eye research tend to focus on the same proteins. Newer resources and tools in proteomics can expand the investigations to lesser‐known proteins of the eye.