bluuebunny/crossref_metadata_2025_split huggingface dataset:
The combination of nanoparticles (NPs) and endophytes boosts Thyme (Thymus vulgaris L.) resistance to drought by elevating levels of phenolic compounds, flavonoids, and essential oils
Authors: Kamyab Afsoun , Samsampour Davood , Ahmadinasab Navid , Bagheri Abdonnabi 
Published: August 2024

Abstract

To assess the growth and biochemical responses of Thymus vulgaris to the application of iron oxide nanoparticles (Fe2O3 NPs) and endophytes under drought stress, a factorial experiment was designed in a completely randomized design (CRD). Experimental treatments included 4 irrigation levels (100, 75, 50, and 25% FC), 4 levels of Fe2O3 NPs (0, 0.5, 1, and 1.5 mgL− 1), and 3 levels of endophytes (control, bacteria and fungi). Drought stress had a detrimental impact on total dry matter (TDM). Inoculation of plants with endophytes and foliar Fe2O3 NPs spraying played a positive role in preserving and increasing the phenolic and flavonoid contents of thyme under drought-stress conditions. The highest total phenolic content (2.86 mg g− 1 FW) and total flavonoid content (4.54 mg g− 1 FW) were observed in plants treated with bacteria along with 1 mgL− 1 Fe2O3 NPs and fungal treatment with 0.5 mgL− 1 Fe2O3 NPs, respectively, under 25% FC irrigation. Exposure to moderate and severe drought stresses increased the predominant phenolic compounds (p-coumaric acid, caffeic acid, and ferulic acid) in the methanolic extract of thyme. During moderate stress conditions (50% FC), bacterial endophytes exerted a more substantial influence on the elevation of p-coumaric acid compared to fungal endophytes. In response to reduced irrigation levels, the essential oil percentage increased in thyme plants, while the predominant constituents of the essential oil, namely thymol and carvacrol, decreased. Endophytes and Fe2O3 NPs positively influenced the percentage of essential oil and the concentrations of thymol and carvacrol in the essential oil.
Modelling the alpha and beta diversity in the community of copepods across tropical and subtropical Atlantic ecoregions: a taxonomic and functional approach
Authors: Martínez-Leiva Lorena , Landeira Jose , de Puelles María Luz Fernández , Hernández-León Santiago , Tuset Víctor , Fatira Effrosyni 
Published: August 2024

Abstract

Copepods, the most abundant individuals of the mesozooplankton group, play a pivotal role in marine food webs and carbon cycling. However, few studies have focused on their diversity and the environmental factors influencing it. The objective of the present study is to model the alpha and beta diversity of copepods across the tropical and subtropical ecoregions of Atlantic Ocean using both taxonomic and functional approaches. The study used a dataset of 226 copepod species collected by stratified plankton hauls (0-800 m depth) across the tropical and equatorial Atlantic, from oligotrophic waters close to the Brazilian coast to more productive waters close to the Mauritanian Upwelling. To perform the functional analysis, six traits related to the behaviour, growth, and reproduction of copepods were selected. Several alpha diversities were estimated using taxonomic metrics (SR, Δ+, and Λ+) and functional metrics (FDis, FEve, FDiv, FOri, FSpe), and modelized with GAM model across spatial, temporal, and environmental gradients. The two components of beta diversity (turnover and nestedness) were shared between ecoregions. The surface layers of oligotrophic, equatorial, and Cape Verde ecoregions displayed higher values of taxonomic indices. More unpredictable were the functional indices, although they showed a tendency to be positive with depth during the daytime. The GAM analysis revealed spatial gradients as the key factors modelling the alpha taxonomic diversity. A similar pattern was found with functional diversity, although it was also influenced by night/daytime. Species turnover drove beta taxonomic diversity, whereas a nesting pattern characterized the functional beta diversity. The community structure of copepods changed across geographical regions, but this was not coupled to functional shifts; instead, functional redundancy was observed.
Intelligent support system for ground settlement management during TBM tunneling by combining machine learning with statistical analysis
Authors: Kwon Kibeom , Kang Minkyu , Kim Dongku , Pham Khanh , Choi Hangseok 
Published: August 2024

Abstract

Ground settlement management is crucial in tunnel boring machine (TBM) tunneling. Previous studies on predicting ground settlement have required substantial assumptions or information, making it challenging to explicitly determine their predictive criteria. This study developed an intelligent TBM operation support system for ground settlement management, by combining machine learning and statistical analysis. Initially, measured settlements were categorized into three classes: heaving, normal, and large settlement. Based on three key features selected through correlation analysis, the predictive criterion for the heaving class was determined using an initial model based on a decision tree algorithm. Subsequently, through statistical analysis, the predictive criteria for the normal and large settlement classes were established. The developed support system, using only three key features, achieved an accuracy of 0.847, F1 score of 0.784, precision of 0.798, and recall of 0.770, outperforming two ensemble machine learning models that used nine features. Moreover, the system can provide explicit predictive criteria, enhancing its practical applicability. Error analysis revealed that among the four instances misclassified by the support system, three pertained to minor settlements within ± 3 mm.
Moon Swirls Unveil the Origin of the Lunar Magnetic Field
Authors: Zuo Boxin , Hu Xiangyun , Wang Lizhe , Cai Yi , Kass Mason Andrew 
Published: August 2024

Abstract

The origin of magnetic anomalies and lunar swirls has long puzzled scientists. The prevailing theory posits that an ancient lunar dynamo core field magnetized extralunar meteoritic materials, leading to the current remnant magnetic anomalies that shield against solar wind ions, thereby contributing to the formation of lunar swirls. Our research reveals that these lunar swirls are the result of ancient electrical currents that traversed the Moon’s surface, generating powerful magnetizing fields impacting both native lunar rocks and extralunar projectile materials. We have reconstructed 3-D distribution maps of these ancient subsurface currents and developed coupling models of magnetic and electric fields that take into account the subsurface density in the prominent lunar maria and basins. Our simulations suggest these ancient currents could have reached density up to 13 A/m², with surface magnetizing field as strong as 469 µT. We propose that these intense electrical current discharges in the crust originate from ancient interior dynamo activity. This phenomenon may be common to celestial bodies with a dynamo core, potentially including Earth.
IRSN-23 Gene Diagnosis Predicts Response to Neoadjuvant Chemotherapy and Refines Breast Cancer Subtype Classification (Prospective Analyses)
Authors: Sota Yoshiaki , Seno Shigeto , Naoi Yasuto , Honma Keiichiro , Shimoda Masafumi , Tanei Tomonori , Matsuda Hideo , Shimazu Kenzo 
Published: August 2024

Abstract

Introduction:
This study evaluates the reproducibility of the IRSN-23 model, which classifies patients into highly chemotherapy-sensitive (Gp-R) or less-sensitive (Gp-NR) groups based on immune-related gene expression using DNA microarray analysis, and its impact on breast cancer subtype classification.
Methods:
Tumor tissues from 146 breast cancer patients receiving preoperative chemotherapy (paclitaxel-FEC) ± trastuzumab at Osaka University Hospital (OUH) were used to classify patients into Gp-R or Gp-NR using IRSN-23. The ability to predict a pathological complete response (pCR) was assessed and the results were validated with independent public datasets (N = 1,282).
Results:
In the OUH dataset, the pCR rate was significantly higher in the Gp-R group than in the Gp-NR group without trastuzumab (29 versus 1%, P = 1.70E-5). In all validation sets without anti-HER2 therapy, the pCR rate in the Gp-R group was significantly higher than that in the Gp-NR group. The pooled analysis of the validation set showed higher pCR rates in the Gp-R group than in the Gp-NR group, both without (N = 1103, 40 versus 12%, P = 2.02E-26) and with (N = 304, 49 versus 35%, P = 0.017) anti-HER2 therapy. Collaboration analyses of IRSN-23 and OncotypeDx or PAM50 could identify highly chemotherapy-sensitive groups and refine breast cancer subtype classification based on the tumor microenvironment (offensive factor - PAM50 and defensive factor - IRSN-23), and the immune subtype was correlated with a better prognosis after NAC.
Conclusions:
This study offers prospective analyses of IRSN-23 in predicting chemotherapy efficacy, showing high reproducibility. The findings indicate the clinical value of using IRSN-23 for refining breast cancer subtype classification, with implications for personalized treatment strategies and improved patient outcomes.
Intraoperative Pulmonary Embolism During General Anesthesia Diagnosed with Transesophageal Echocardiography: A Case Report
Authors: Rafizadeh M.D. Sassan , Abikenari M.S Matthew , Kakazu  
Published: August 2024

Abstract

Acute pulmonary embolism (APE) can be a life-threatening event with significant morbidity and mortality, particularly in the perioperative period. While early detection and intervention are essential, the common signs and symptoms are not overtly detectable under general anesthesia. Here, we present a case of an otherwise healthy 43-year-old female who presented with an intraoperative pulmonary embolism during general anesthesia for left patella tendon repair following a ground-level fall. Rescue transesophageal echocardiography (TEE) revealed a thrombus in the right main pulmonary artery and signs of right heart strain, including tricuspid regurgitation and right ventricular dilation. The patient was emergently taken to the interventional radiology suite and treated with catheter thrombectomy. The patient’s condition stabilized post-procedure, and she was subsequently discharged with anticoagulation therapy. The current case study elucidates the clinical challenges of diagnosing intraoperative APE, particularly in anesthetized patients where typical symptoms are masked. Intraoperative TEE played a pivotal role in early embolism detection and facilitated prompt, life-saving intervention. This case recapitulates the vital importance of utilizing advanced diagnostic tools in managing intraoperative emergencies. Future studies on developing pathophysiologic models and flowcharts specifically for intraoperative APE could significantly reduce adverse outcomes in diagnostically challenging cases.
Preliminary Feasibility and Efficacy of a Brief Behavioural Treatment for Insomnia after Acquired Brain Injury: A Case Series
Authors: Gardani Maria , Baylan Satu , Zouhar Veronika 
Published: August 2024

Abstract

Insomnia after Acquired Brain Injury (ABI) is common and can negatively impact individuals’ rehabilitation, recovery and quality of life. The present study investigated the feasibility and preliminary efficacy of a Brief Behavioural Treatment for Insomnia (BBTI) in a community sample following ABI. Ten participants were recruited. Seven participants attended four weekly sessions of BBTI and kept a daily sleep diary. Participants completed a semi-structured sleep interview at baseline and self-report measures of sleep, anxiety and depression pre- and post-treatment as well as a treatment acceptability questionnaire post-treatment. Follow-up data were collected at one, two- and three-months post-treatment. Visual analyses of the data were performed on a case-by-case basis. Five participants (71%) demonstrated clinically significant improvements in sleep questionnaire measures, one showed treatment response and one (14%) showed nonresponse post-treatment. Treatment effects on sleep outcomes were either maintained or augmented at follow-ups. BBTI was found to be well-tolerable, as evidenced by high overall retention rates (70%) and positive feedback on the treatment acceptability questionnaire. These results provide preliminary evidence of BBTI being both feasible to use and efficacious in individuals with post-brain-injury insomnia. Larger-scale randomised controlled trials are needed to establish the effectiveness of BBTI following ABI.
Genotyping and Antiretroviral Drug Resistance Mutations among HIV Patients in Southern Santa Catarina, Brazil
Authors: Mendes Marcon Chaiana Esmeraldino , Schlindwein Aline Daiane , de Macedo Brigido Luis Fernando , Lopez-Lopes Giselle Ibette , Cabral Gabriela Bastos , Schuelter-Trevisol Fabiana 
Published: August 2024

Introduction:
Therapeutic measures have been successful in increasing survival rates
and quality of life of HIV/AIDS-infected people. However, some people fail to respond to antiretroviral
therapy (HAART) because of viral resistance-associated mutations.

Objective:
To identify virus genotype and the presence of mutations that alter the susceptibility to
HAART, and factors associated with the occurrence of these mutations.

Methods:
A cross-sectional study was conducted on adults living with HIV attending a specialized
outpatient clinic in southern Santa Catarina, Brazil. The participants were interviewed and had
blood samples collected for analysis. Those with detectable viral load were genotyped.

Results:
Out of the 629 patients recruited, 127 subjects were included due to having a detectable
viral load. The most common mutations were M184V and K103N. HIV-1 subtype C was the most
prevalent strain. Resistance to HAART was associated with modification in the treatment regimen
(p <0.001).

Conclusion:
This study concluded that the circulating subtype virus was subtype C and that the
mutations K103N and M184V were the most prevalent strains in southern Santa Catarina, Brazil.
Effects of Auditory and Visual White Noise on Oculomotor Inhibition in Children With Attention-Deficit/Hyperactivity Disorder: Protocol for a Crossover Study
Authors: Jostrup Erica , Nyström Marcus , Tallberg Pia , Söderlund Göran , Gustafsson Peik , Claesdotter-Knutsson Emma 
Published: August 2024

Background
In attention-deficit/hyperactivity disorder (ADHD), poor inhibitory control is one of the main characteristics, with oculomotor inhibition impairments being considered a potential biomarker of the disorder. While auditory white noise has demonstrated the ability to enhance working memory in this group, visual white noise is still unexplored and so are the effects of both types of white noise stimulation on oculomotor inhibition.

Objective
This crossover study aims to explore the impact of auditory and visual white noise on oculomotor inhibition in children with ADHD and typically developing (TD) children. The study will investigate the impact of different noise levels (25% and 50% visual, 78 dB auditory), and performance will be evaluated both with and without noise stimulation. We hypothesize that exposure to white noise will improve performance in children with ADHD and impair the performance for TD children.

Methods
Memory-guided saccades and prolonged fixations, known for their sensitivity in detecting oculomotor disinhibition in ADHD, will be used to assess performance. Children diagnosed with ADHD, withdrawing from medication for 24 hours, and TD children without psychiatric disorders were recruited for the study.

Results
Data collection was initiated in October 2023 and ended in February 2024. A total of 97 participants were enrolled, and the first results are expected between September and November 2024.

Conclusions
This study will examine whether cross-modal sensory stimulation can enhance executive function, specifically eye movement control, in children with ADHD. In addition, the study will explore potential differences between auditory and visual noise effects in both groups. Our goal is to identify implications for understanding how noise can be used to improve cognitive performance.

Trial Registration
ClinicalTrials.gov NCT06057441; https://clinicaltrials.gov/study/NCT06057441

International Registered Report Identifier (IRRID)
DERR1-10.2196/56388
Análise textual discursiva enquanto um cenário viável para as pesquisas qualitativas na área de educação
Authors: Rezende da Silva Arthur , De Souza Marcelino Valéria 
Published: August 2024

O objetivo deste trabalho é analisar a relação da Análise Textual Discursiva (ATD) enquanto metodologia qualitativa no campo da educação. Para isso, optou-se por uma coleta de dados a partir de um Estado da Arte, envolvendo teses de doutorado de programas de pós-graduação em educação, oriundas do Banco de Teses e Dissertações da CAPES, no período de 2018 a 2021. A partir desse compilamento, analisamos os resumos de cada tese e a metodologia de compreensão desses resumos foi a ATD. Com o propósito de dar consistência à referida investigação, o estudo baseou-se na seguinte questão norteadora: O que apontam as pesquisas dos programas de doutorado em educação cuja escolha metodológica foi a ATD? Como resultado, o estudo possibilitou compreender o potencial da ATD no campo da educação, tendo em vista os variados apontamentos das teses de doutorado, desde desafios e adversidades dentro do campo até os horizontes possíveis. Assim, pelo seu caráter hermenêutico e fenomenológico, a ATD se mostra como um caminho possível nas pesquisas qualitativas no campo da educação, visto que possibilita um esforço permanente de construir e expressar novas compreensões sobre os fenômenos investigados.

Palavras-chave: Análise Textual Discursiva (ATD); Pesquisa qualitativa em Educação; Pós-Graduação em Educação
Violência doméstica contra a mulher em tempos de pandemia
Authors: Oliveira Hilderline , Rodrigues Maria Emilia 
Published: August 2024

A pandemia de Covid-19 criou novas formas de convivência, no âmbito social e no privado. O aumento da violência doméstica contra a mulher é um exemplo desse ‘novo normal’. Nesse cenário de Covid-19, na realidade brasileira, o presente artigo visa analisar em que medida o isolamento social contribuiu para o aumento dos dados da violência doméstica contra a mulher. Trata-se de uma pesquisa bibliográfica e documental, de caráter exploratório e abordagem quantitativa e qualitativa. Os resultados indicaram que houve um significativo aumento dos casos de violência doméstica contra a mulher durante o isolamento social adotado na pandemia, pois a denúncia se tornou mais difícil — o que afetou, consequentemente, a resolução dos casos.
"Um instante por favor meu filho está me chamando": notas sobre maternidade e trabalho pós-março de 2020 a partir do Youtube
Authors: Lopes Luis Fernando , Cavazzani André Luiz M. 
Published: August 2024

Este estudo, de caráter bibliográfico e documental, tem como objetivo recolher, analisar e constituir memória a partir de depoimentos de mulheres professoras pesquisadoras e acadêmicas que debatem publicamente, em meio digital, a partir da plataforma YouTube, os desafios decorrentes da necessidade de conciliar maternidade e atividades acadêmicas profissionais no período pós-março de 2020. As análises dos discursos dessas mães consideraram pressupostos teóricos da fenomenologia, que tem como um de seus princípios fundamentais a necessidade de suspender os pré-juízos e dar voz aos sujeitos de pesquisa, com vistas a descrever o fenômeno estudado reconhecendo sentidos e significados. Dado o volume elevado de vídeos encontrados a partir dos descritores “mães pesquisadoras” e “pandemia”, esta pesquisa considerou os 25 primeiros resultados referentes ao período entre pós-março de 2020 até dezembro de 2021, os quais indicam que as tecnologias digitais, com destaque para as redes sociais e aplicativos para transmissões ao vivo, foram e ainda são instrumentos fundamentais de apoio a mães pesquisadoras e professores de maneira geral. Além disso, constata-se que o material disponível no YouTube, entre outras redes sociais e plataformas, constitui fonte muito rica e ainda pouco explorada para realização de pesquisas acadêmicas, sobretudo para o campo educacional.
Arquitetura pedagógica e o uso de objetos digitais de aprendizagem:computação afetiva em ambientes virtuais de aprendizagem
Authors: Gava Gustavo , Haviaras Mariana 
Published: August 2024

Nesta pesquisa, buscou-se discutir uma necessidade pedagógica que vem se destacando celeremente nos últimos anos à Educação e, principalmente, devido ao fenômeno da pandemia causado pelo coronavírus: a urgência de ambientes virtuais de aprendizagem capazes de potencializar a sensação de pertencimento nos estudantes. Diante dessa questão, o objetivo final dessa pesquisa foi idear um Objeto Digital de Aprendizagem (ODA), tendo como mote as dores dos estudantes de uma Instituição de Ensino Superior (IES). O intuito foi o de apresentar uma proposta de um ODA pensado de forma situacional, a fim de potencializar o uso do próprio Ambiente Virtual de Aprendizagem (AVA), e de instigar o sentimento de pertencimento a um lugar (virtual) entre docente e discente, ou seja, a relação afetiva mesmo em ciberespaço. Para isso, questionou-se: como seria possível a relação afetiva por meio de um ambiente virtual que busca promover a aprendizagem? A fundamentação metodológica dessa pesquisa foi subdividida em três momentos e por meio de natureza triangular: bibliográfica, qualitativa e exploratória-retrodutiva (a de construir uma hipótese). Em geral, o resultado alcançado nessa pesquisa demostra que existem alguns fatores que devem ser considerados na relação afetiva e o sentimento de pertencimento entre os estudantes: a qualidade de acesso à Internet, a arquitetura pedagógica do ambiente virtual e a experiência neurocognitiva com os objetos digitais. Por fim, destacou-se uma proposta de objeto digital de aprendizagem denominado “Conecta Mais” que se encontra em fase piloto de aplicação em uma Instituição de Ensino Superior do Estado do Paraná.