bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isokinetic Strength Profile of Shoulder Internal and External Rotators of Adolescent Volleyball Players
Authors: Harput Gulcan , Guney Hande , Colakoglu Fatma Filiz , Baltacı Gul 
Published: December 2014

Objectives: The aim of this study was to investigate the effects of limb dominance and gender on isometric, eccentric and concentric strength of the shoulder internal and external rotator muscles in adolescent volleyball players. Methods: Forty adolescent volleyball players [Male: 23( Age: 15.5±1.4 yrs, Body weight: 72±10.2 kg, Height: 184.4±7.6 cm, BMI: 20.9±2.6 kg/m2), Female: ( Age: 16.7±0.9 yrs, Body weight: 60.7±8.2 kg, Height: 172.5±5.3 cm, BMI: 20.4±2.3 kg/m2) participated in this study. Isomed 2000 isokinetic dynamometer was used to measure muscle strength testing. Isometric strength testing of shoulder internal and external rotator muscles were performed at 90 ° shoulder abduction and external rotation position. In the same position, concentric and eccentric muscle testing was performed at 90°/s angular velocity. Strength outcomes were recorded as Nm/kg. 2-way repeated measures of ANOVA was used for statistical analysis. Results: Dominance by gender interaction was not found significant for internal rotator (IR) and external rotator (ER) muscles' strength (IR: F(1,72)=2.87, p=0.06, ER: F(1,72)=1.98, p=0.15). There was a significant strength by dominance interaction for internal rotator muscles (F(2,72)=18.52, p<0.001). Isometric strength was greater in dominant limb (p<0.001)while concentric strength was found greater in non-dominant limb(p=0.006). Eccentric strength was found similar for limbs (p=0.18). IR muscles showed greater strength during eccentric (1.03±0.05), concentric (0.76±0.03) and isometric test (0.69±0.03), respectively. On the other hand, external rotators showed greater strength during eccentric (0.49±0.4), isometric (0.40±0.3) and concentric test (0.36±0.3), respectively. There was no significant gender effect on the strength (IR: F(2,72)=0.31, p=0.73, ER: F(2,72)=0.42, p=0.66). Conclusion: The strength of shoulder internal and external rotator muscles do not differ according to gender in adolescent volleyball players. Limb dominance has an effect on the strength of internal rotator muscles while it has no effect on the strength of external rotators. Both muscle groups show greater strength during eccentric testing.
HIV-1 reprograms the migration of macrophages
Authors: Vérollet Christel , Souriant Shanti , Bonnaud Emilie , Jolicoeur Paul , Raynaud-Messina Brigitte , Kinnaer Cassandre , Fourquaux Isabelle , Imle Andrea , Benichou Serge , Fackler Oliver T. , Poincloux Renaud , Maridonneau-Parini Isabelle 
Published: December 2014

Key PointsHIV-1 Nef reprograms human macrophage migration favoring the mesenchymal mode, which translates in vivo to macrophage tissue accumulation. Nef enhances mesenchymal migration by influencing podosome organization and function via the phagocyte-specific kinase Hck and WASP.
Synthesis of 2-cyclopropyl-3-(5-aryl-1H-pyrazol-3-yl)-1,8-naphthyridine
Authors: Bucha Mallaiah , Eppakayala Laxminarayana , Maringanti Thirumala Chary , Tharikoppula Giri , Kethireddy Shashikala 
Published: December 2014

Abstract

Background
1,8-Naphthyridine derivatives have attracted considerable attention because the 1,8-naphthyridine skeleton is present in many compounds that have been isolated from natural substances, with various biological activities.

Findings

N,N-dimethoxy-N-methyl-1,8-naphthyridine-3-carboxamide (1) on reaction with Grignard reagent forms 2-methoxy-1,8-naphthyridine-3-carbaldehyde (2). Compound 2 on reaction with different aromatic aldehydes provided 1-(2-cyclopropyl-1,8-naphthyridin-3-yl)-3-arylprop-2-en-1-ones (3a-e) and these compounds on cyclisation with hydrazine hydrate 99% yielded 2-cyclopropyl-3-(5-aryl-1H-pyrazol-3-yl)-1,8-naphthyridines (4-a-e).
Synthesis of the target compounds involved the formation of 4a-e. It was accomplished using Grignard reaction, condensation reaction, and cyclisation reactions. All the synthesized compounds were readily soluble in DMSO. Spectral data of the synthesized compounds were in full agreement with the proposed structures.

Conclusions
In conclusion, we have developed a simple and an efficient Synthesis of 2-cyclopropyl-3-(5-aryl-1H-pyrazol-3-yl)-1,8-naphthyridine.
Seasonal and reproductive effects on wound healing in the flight membranes of captive big brown bats
Authors: Ceballos-Vasquez Alejandra , Caldwell John R. , Faure Paul A. 
Published: December 2014

ABSTRACT
The flight membranes of bats serve a number of physiological functions important for survival. Although flight membrane injuries are commonly observed in wild-caught bats, in most cases the damage heals completely. Previous studies examining wound healing in the flight membranes of bats have not taken into consideration energy constraints that could influence healing times. Wound healing results in increased energy demands, therefore we hypothesized that wound healing times would be slower during periods of energy conservation and/or energy output. In this study we used an 8 mm diameter circular punch tool to biopsy the wing membranes of healthy adult female big brown bats (Eptesicus fuscus) from a captive research colony to test the hypothesis that healing times will vary with seasonal temperature changes between the summer and winter seasons, and with reproductive condition between lactating and non-reproductive females. As expected, membrane biopsies took significantly longer to heal during the winter when bats were hibernating compared to the summer when bats were active. Surprisingly, no difference in healing time was observed between lactating and non-reproductive females. The wings of most bats fully healed, although some individuals showed wound expansion demonstrating that impaired healing is occasionally observed in otherwise healthy subjects.
Web-based Comparative Patient-reported Outcome Feedback to Support Quality
Improvement and Comparative Effectiveness Research in Total Joint Replacement
Authors: Zheng Hua , Li Wenjun , Harrold Leslie , Ayers David C. , Franklin Patricia D. 
Published: December 2014

Introduction: Patient-reported outcomes (PROs) are rarely included in quality
monitoring systems, surgeon comparative feedback reports, or registries. We present the
design and implementation of a secure website in a federally funded research
program—Function and Outcomes Research for Comparative Effectiveness in Total Joint
Replacement (FORCE-TJR)—to return comparative PRO reports to participating surgeons, in
addition to including traditional quality measures, in order to monitor and improve
quality and health outcomes.Methods: The surgeon-specific comparative PRO reports were
designed and structured based on user input for content, data elements, integration, and
display. Three questions are addressed regarding the knee and hip joint symptom profiles
of patients before TJR, as well as outcomes of surgery. The website is organized with a
hierarchical structure to display data at national, practice, and individual surgeon
levels, and provides a comprehensive site-level executive summary and surgeon-level data
reports that can be downloaded.Early Results: As of September 2014, over 22,000 patients
were enrolled from more than 130 surgeons in 22 states. The reporting website was
launched in September 2012 and has been updated quarterly for all surgeons to review
their site- and individual-specific outcomes data compared to national
benchmarks.Discussion: In this novel system, quarterly comparative surgeon feedback
extends beyond traditional measures of complication rates to include PROs of pain relief
and functional gain. We anticipate that this enhanced data will facilitate
patient-centered quality improvement (QI) and outcomes research from the registry. As
the Centers for Medicare & Medicaid Services (CMS) and other insurers consider
future implementation of PROs, surgeons will increasingly need comparative data by which
to self-monitor their practice outcomes.
Touching the ineffable: Collective creative collaboration, education and the secular-spiritual in performing arts
Authors: Jamieson Evelyn 
Published: December 2014

Abstract
This article considers a range of spiritual, psychological and pedagogical writing to examine whether the contemporary notion of ‘secular-spirituality’ can move forward our understanding of collaborative working processes in the performing arts. With reference to Anttila, Bigger, Bini, Czikszentmihalyi, Lave and Wenger, James, Roff, and Van Ness, the article focuses on the rehearsal room interplay of life world and social world through three key notions. These are ‘embodied knowing’, ‘bodily intelligence’ and ‘belonging’ in relation to the individual in the wider collaborative process. Some working practices of Forced Entertainment – as discussed by Tim Etchells – are then considered as a concluding and practice-based referent.
Returning to the dancing body: Honouring our divinity through dance
Authors: Kurnaedy Karen 
Published: December 2014

Abstract
This article is an invitation to celebrate and honour the divinity of the dance in each person. The phrase ‘returning to the dancing body’ highlights the inherent vitality, renewal and communion with the divine that may be experienced through dancing and may be experienced over and over as we return to the dance to refresh and cultivate a spiritual self. The physical body engaged holistically in movement with a phenomenological focused awareness appears to have the potential for us to experience our spirituality in new and rejuvenating ways. Honouring the body, movement and the sacred vitality of the dance may broaden our concepts and connections to our selves and the numinous, and allow experiences of unification and vital aliveness to occur.
Analysis of Model Variance for Ensemble Based Turbulence Modeling
Authors: Jiang Nan , Kaya Songul , Layton William 
Published: December 2014

Abstract
This report develops an ensemble or statistical eddy viscosity model.
The model is parameterized by an ensemble of solutions of an ensemble-Leray
regularization. The combined approach of ensemble time stepping and ensemble
eddy viscosity modeling allows direct parametrization of the turbulent
viscosity coefficient. We prove unconditional stability and that the model's solution approaches statistical equilibrium as t → ∞; the model's variance converges to zero as t → ∞. The ensemble method is used to interrogate a rotating flow, testing its predictability by computing effective averaged Lyapunov exponents.
Pitfalls in hormonal diagnosis of 17-beta hydroxysteroid dehydrogenase III deficiency
Authors: Khattab Ahmed , Yuen Tony , Yau Mabel , Domenice Sorahia , Frade Costa Elaine Maria , Diya Kazmi , Muhuri Dwaipayan , Pina Christian Enrique , Nishi Mirian Yumie , Yang Amy C. , de Mendonça Berenice Biharinho , New Maria I. 
Published: December 2014

AbstractSteroid 17β-hydroxysteroid dehydrogenase III (17β-HSD3) deficiency is a rare autosomal recessive disorder that usually presents in patients with a 46,XY karyotype with ambiguous genitalia at birth. The 17β-HSD3 enzyme, which is encoded by the
Carbohydrate-lipid profile and use of metformin with micronized fenofibrate in reducing metabolic consequences of craniopharyngioma treatment in children: single institution experience
Authors: Kalina Maria Aleksandra , Wilczek Marta , Kalina-Faska Barbara , Skała-Zamorowska Eliza , Mandera Marek , Małecka Tendera Ewa 
Published: December 2014

AbstractTo evaluate auxology and metabolic disturbances in children with craniopharyngioma, and to present observational results of treatment of metabolic sequels with metformin and micronized fenofibrate.The studied group comprised 22 children [median age at diagnosis 10.5 (0.17–16.75) years; median follow-up 5.1 years]. Assessment included height standard deviations (SDS), body mass index (BMI) SDS, concentrations of lipids, glucose and insulin (fasting or oral glucose tolerance test) and homeostatic model assessment of insulin resistance (HOMA-IR) index. Ten adolescents with hyperinsulinemia and dyslipidemia received therapy with metformin (500–1500 mg/daily) and micronized fenofibrate (160 mg/daily).At diagnosis, median hSDS was –1.66 (range: –4.08; +0.1). Nine (40.9%) children were growth hormone-treated. There was gradual increase of BMI SDS, 18 (81.8%) patients being overweight at the final assessment. Dyslipidaemia was found in 19 patients (86.4%), hyperinsulinaemia in 11 patients (50%) and elevated HOMA-IR in 15 patients (68.2%). Decrease of triglycerides [median 263.5 (171–362) mg/dL vs. 154 (102–183) mg/dL] and HOMA-IR [8.64 (5.08–12.65) vs. 4.68 (0.7–7.9)] was significant in the group treated with metformin and fenofibrate for 6 months.Significant auxologic changes and metabolic abnormalities were found in children treated for craniopharyngioma. The use of metformin and fenofibrate seemed to attenuate these disturbances in a short-term observation.
Marker-Based Estimation of Heritability in Immortal Populations
Authors: Kruijer Willem , Boer Martin P , Malosetti Marcos , Flood Pádraic J , Engel Bas , Kooke Rik , Keurentjes Joost J B , van Eeuwijk Fred A 
Published: December 2014

Abstract
Heritability is a central parameter in quantitative genetics, from both an evolutionary and a breeding perspective. For plant traits heritability is traditionally estimated by comparing within- and between-genotype variability. This approach estimates broad-sense heritability and does not account for different genetic relatedness. With the availability of high-density markers there is growing interest in marker-based estimates of narrow-sense heritability, using mixed models in which genetic relatedness is estimated from genetic markers. Such estimates have received much attention in human genetics but are rarely reported for plant traits. A major obstacle is that current methodology and software assume a single phenotypic value per genotype, hence requiring genotypic means. An alternative that we propose here is to use mixed models at the individual plant or plot level. Using statistical arguments, simulations, and real data we investigate the feasibility of both approaches and how these affect genomic prediction with the best linear unbiased predictor and genome-wide association studies. Heritability estimates obtained from genotypic means had very large standard errors and were sometimes biologically unrealistic. Mixed models at the individual plant or plot level produced more realistic estimates, and for simulated traits standard errors were up to 13 times smaller. Genomic prediction was also improved by using these mixed models, with up to a 49% increase in accuracy. For genome-wide association studies on simulated traits, the use of individual plant data gave almost no increase in power. The new methodology is applicable to any complex trait where multiple replicates of individual genotypes can be scored. This includes important agronomic crops, as well as bacteria and fungi.
Mitotic Accumulation of Dimethylated Lysine 79 of Histone H3 Is Important for Maintaining Genome Integrity During Mitosis in Human Cells
Authors: Guppy Brent J , McManus Kirk J 
Published: December 2014

Abstract
The loss of genome stability is an early event that drives the development and progression of virtually all tumor types. Recent studies have revealed that certain histone post-translational modifications exhibit dynamic and global increases in abundance that coincide with mitosis and exhibit essential roles in maintaining genomic stability. Histone H2B ubiquitination at lysine 120 (H2Bub1) is regulated by RNF20, an E3 ubiquitin ligase that is altered in many tumor types. Through an evolutionarily conserved trans-histone pathway, H2Bub1 is an essential prerequisite for subsequent downstream dimethylation events at lysines 4 (H3K4me2) and 79 (H3K79me2) of histone H3. Although the role that RNF20 plays in tumorigenesis has garnered much attention, the downstream components of the trans-histone pathway, H3K4me2 and H3K79me2, and their potential contributions to genome stability remain largely overlooked. In this study, we employ single-cell imaging and biochemical approaches to investigate the spatial and temporal patterning of RNF20, H2Bub1, H3K4me2, and H3K79me2 throughout the cell cycle, with a particular focus on mitosis. We show that H2Bub1, H3K4me2, and H3K79me2 exhibit distinct temporal progression patterns throughout the cell cycle. Most notably, we demonstrate that H3K79me2 is a highly dynamic histone post-translational modification that reaches maximal abundance during mitosis in an H2Bub1-independent manner. Using RNAi and chemical genetic approaches, we identify DOT1L as a histone methyltransferase required for the mitotic-associated increases in H3K79me2. We also demonstrate that the loss of mitotic H3K79me2 levels correlates with increases in chromosome numbers and increases in mitotic defects. Collectively, these data suggest that H3K79me2 dynamics during mitosis are normally required to maintain genome stability and further implicate the loss of H3K79me2 during mitosis as a pathogenic event that contributes to the development and progression of tumors.
Air Abrasion Before and/or After Zirconia Sintering: Surface Characterization, Flexural Strength, and Resin Cement Bond Strength
Authors: Abi-Rached FO , Martins SB , Almeida-Júnior AA , Adabo GL , Góes M Sousa , Fonseca RG 
Published: December 2014

SUMMARY
The purpose of this in vitro study was to evaluate the effect of air-abrasion/zirconia sintering order on the yttria partially stabilized tetragonal zirconia polycrystal (Y-TZP) surface characterization (roughness, morphology, and phase transformation), flexural strength (FS), and shear bond strength (SBS) to a resin cement. Y-TZP specimens were air abraded with 50-μm Al2O3 particles after (AS), before (BS), or before and after zirconia sintering (BAS). For roughness (Ra), 30 block specimens (12×12×3.0 mm; n=10) had their surfaces analyzed by a profilometer. Next, on the air-abraded surfaces of these specimens, composite resin discs (n=30) were bonded with RelyX ARC. The bonded specimens were stored for 24 hours in distilled water at 37°C before shear testing. Failure mode was determined with a stereomicroscope (20×). The surface morphology (n=2) was evaluated by SEM (500×). For the four-point flexural strength test (EMIC DL2000), 39 bar-shaped specimens (20×4.0×1.2 mm; n=13) were air abraded according to the three conditions proposed, and an additional group (nonabraded) was evaluated (n=13). The quantitative analysis of phase transformation (n=1) was completed with Rietveld refinement with X-ray diffraction data. Ra (μm) and SBS (MPa) data were analyzed by one-way analysis of variance (ANOVA) and the Tukey test (α=0.05). Pearson correlation analysis was used to determine if there was a correlation between roughness and SBS. For FS (MPa) data, one-way ANOVA and the Dunnett C-test (α=0.05) were used. The air-abrasion/zirconia sintering order influenced significantly (p&lt;0.001) Ra, SBS, and FS. The BS and AS groups presented the highest (1.3 μm) and the lowest (0.7 μm) Ra. The highest SBS (7.0 MPa) was exhibited by the BAS group, followed by the AS group (5.4 MPa) and finally by the BS group (2.6 MPa). All groups presented 100% adhesive failure. A weak correlation (r=−0.45, p&lt;0.05) was found between roughness and SBS. The air-abrasion/zirconia sintering order provided differences in the surface morphology. The nonabraded (926.8 MPa) and BS (816.3 MPa) groups exhibited statistically similar FS values but lower values than the AS (1249.1 MPa) and BAS (1181.4 MPa) groups, with no significant difference between them. The nonabraded, AS, BS, and BAS groups exhibited, respectively, percentages of monoclinic phase of 0.0 wt%, 12.2 wt%, 0.0 wt%, and 8.6 wt%. The rougher surface provided by the air-abrasion before zirconia sintering may have impaired the bonding with the resin cement. The morphological patterns were consistent with the surface roughness. Considering the short-term SBS and FS, the BAS group exhibited the best performance. Air abrasion, regardless of its performance order, provides tetragonal to monoclinic transformation, while sintering tends to zero the monoclinic phase content.
Are Sportspersons Good Moral Role Models?
Authors: Melin Roger 
Published: December 2014

Abstract
It has been thought that sportspersons, through their participation in sport, acquire moral attitudes and behavior that make them good moral role models. These moral attitudes and behavior can be called the ethos of sport, and consist of the principles of fair play and courage, justice, and honesty. In this article, it is argued that this belief is mistaken. Through four very common examples of sporting practice, it is shown that sport, contrary to providing a good basis for proper moral behavior, promotes what otherwise would be called non-moral attitudes and behavior. As a conclusion, it is pointed out that sportspersons might very well be good moral role models, but that they would be moral role models in spite of the fact that they are involved in sporting activities.
First-principles study of solid methane at high pressure
Authors: Pantha Nurapati , Acharya Jagaran , Adhikari Narayan Prasad 
Published: December 2014

We study the structural and electronic properties of solid methane of space group P212121 at high pressure. The density-functional theory (DFT) based first-principles calculations within the Generalized Gradient Approximations (GGA) have been performed by using Quantum Espresso package. Our findings show that the solid methane in orthorhombic structure compresses fast at the first, and then slowly as a function of elevated hydrostatic pressure. The pressure-volume diagram agrees with the available previously reported data up to pressure of around 200 GPa. In orthorhombic structure, solid methane is a wide band gap insulator at low pressures (tens of GPa). The band gap decreases with increase in the pressure. At high pressure (around 900 GPa), the band gap decreases to semi-conductor range (1.78 eV). Our results reveal that methane to be metallic above the pressure coverage of the present study which is consistent to the interior of the giant planets. The band gap as a function of pressure (from the present work) agrees well with the previously reported data. DOI: http://dx.doi.org/10.3126/bibechana.v12i0.11779BIBECHANA 12 (2015) 70-79
Conductometric study of nickel chloride in ethanol-water mixed solvent media at various temperatures
Authors: Basnet Nabin , Bhattarai Ajaya 
Published: December 2014

The conductivity measurement of nickel chloride has been done in binary solvent of the ethanol-water system. The different percentage of ethanol including 10, 20, 30, 40, 50, 60, 70, 80, 90 and 100 (v/v) has been chosen as binary solvents. The concentration of the electrolyte in the prepared solutions varies from 0.008 to 0.1 mol.l-1 for temperatures 298.15 K, 303.15 K and 308.15 K. The conductivity of the electrolyte decreases with increase in ethanol content in the solvent at a particular temperature, which is due to the decrease in dielectric constant of the medium. The conductivity increases with increase in temperature and concentration, due to increase in mobility of ions and number of ions from observed electrolyte respectively. DOI: http://dx.doi.org/10.3126/bibechana.v12i0.11789BIBECHANA 12 (2015) 128-134