bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wet‐Printed Stretchable and Strain‐Insensitive Conducting Polymer Electrodes: Facilitating In Vivo Gastric Slow Wave Mapping
Authors: Zhang Peikai , Athavale Omkar N. , Zhu Bicheng , Travas‐Sejdic Jadranka , Du Peng 
Published: July 2024

AbstractWearable and implantable devices play a crucial role in clinical diagnosis, disease treatment, and fundamental research on the body's electrophysiology and biochemical processes. Conducting polymers are emerging as promising solutions to surpass the limitations of traditional metal‐based electrodes, offering enhanced conformability, and stretchability. However, current microfabrication techniques of CP electrodes have a number of limitations. In this study, a novel wet‐printing technique is developed for the fabrication of highly stretchable poly(3,4‐ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS) microelectrodes. The wet‐printing, conducted in a liquid coagulation bath, has the advantages of being non‐contact, easy and fast to perform, and capable of printing low‐viscosity inks. Wet‐printing of PEDOT:PSS lines with a width of ≈20 µm is demonstrated. By adding D‐sorbitol as a plasticizer, an ultra‐high stretchability of PEDOT:PSS electrodes, of more than 720% is achieved while the electrodes remained conductive and strain‐insensitive up to high strains. The use of PEDOT:PSS wet‐printed electrode arrays for the electrophysiological recording from the stomach is demonstrated. The stretchable electrodes conformed swell to the tissue and recorded comparable electrophysiological signals to Au‐plated electrodes in porcine and rodent animal models. The wet‐printing approach to fabricating flexible and stretchable electrode arrays using low‐viscosity, conducting inks holds promise for applications in conformable electronics.
Magnesium Chalcogenide Nanocrystals and Their Core/Shell Nanostructures
Authors: Yu Chunyu , Li Yibo , Song Xuerong , Wang Yinghui , Ning Jiajia 
Published: July 2024

AbstractMagnesium chalcogenide with wide bandgap semiconductor is an important candidate for the next generation semiconductor for optoelectronic devices. Colloidal magnesium chalcogenide (MgS, MgSe, and MgTe) nanocrystals are produced with the colloidal method, showing the optoelectronic properties for wide bandgap semiconductors in the violet region. The shape and size of magnesium chalcogenide nanocrystals are precisely controlled via tuning the precursors and ligands. Magnesium chalcogenide are further deposited on ZnSe and ZnS quantum dots for shell materials to enhance fluorescence emission due to the wide bandgap and suitable lattice in magnesium chalcogenide. Magnesium chalcogenide in nanoscale exhibits the potential for wide‐band semiconductors and the shell materials to light‐emitting quantum dots.
Forkhead Box Protein K1 Promotes Chronic Kidney Disease by Driving Glycolysis in Tubular Epithelial Cells
Authors: Zhang Lu , Tian Maoqing , Zhang Meng , Li Chen , Wang Xiaofei , Long Yuyu , Wang Yujuan , Hu Jijia , Chen Cheng , Chen Xinghua , Liang Wei , Ding Guohua , Gan Hua , Liu Lunzhi , Wang Huiming 
Published: July 2024

AbstractRenal tubular epithelial cells (TECs) undergo an energy‐related metabolic shift from fatty acid oxidation to glycolysis during chronic kidney disease (CKD) progression. However, the mechanisms underlying this burst of glycolysis remain unclear. Herein, a new critical glycolysis regulator, the transcription factor forkhead box protein K1 (FOXK1) that is expressed in TECs during renal fibrosis and exhibits fibrogenic and metabolism‐rewiring capacities is reported. Genetic modification of the Foxk1 locus in TECs alters glycolytic metabolism and fibrotic lesions. A surge in the expression of a set of glycolysis‐related genes following FOXK1 protein activation contributes to the energy‐related metabolic shift. Nuclear‐translocated FOXK1 forms condensate through liquid‐liquid phase separation (LLPS) to drive the transcription of target genes. Core intrinsically disordered regions within FOXK1 protein are mapped and validated. A therapeutic strategy is explored by targeting the Foxk1 locus in a murine model of CKD by the renal subcapsular injection of a recombinant adeno‐associated virus 9 vector encoding Foxk1‐short hairpin RNA. In summary, the mechanism of a FOXK1‐mediated glycolytic burst in TECs, which involves the LLPS to enhance FOXK1 transcriptional activity is elucidated.
Hollow Octahedral Pr6O11‐Mn2O3 Heterostructures for High‐Performance Aqueous Zn‐Ion Batteries
Authors: Liu Qiang , Fan Guilan , Zeng Yinxiang , Zhang Xiaotao , Luan Deyan , Guo Yan , Gu Xiaojun , Lou Xiong Wen (David) 
Published: July 2024

AbstractMn‐based oxides are broadly prospected cathode materials for aqueous Zn‐ion batteries (AZIBs) due to their rich abundance, low cost, and plentiful valence states. However, the further development of Mn‐based oxides is severely restricted by the dissolution of active materials and poor structural stability. Herein, hollow octahedral Pr6O11‐Mn2O3 (denoted as PrO‐MnO) heterostructures are developed through a facile metal–organic framework‐engaged templating approach, which realizes boosted Zn ion storage performance. Pr6O11 can not only effectively suppress the dissolution of Mn to stabilize Mn2O3 but also induce interfacial charge rearrangement and promote electron/ion transfer, contributing to the improved electrochemical activity and stability of PrO‐MnO. Moreover, the rationally designed hollow nanostructure offers sufficient active sites and facilitates the reaction kinetics. As expected, the PrO‐MnO cathode exhibits excellent rate and cycling performance with a high reversible capacity of 140.8 mAh g−1 after 2000 cycles at 1 A g−1, outperforming the Mn2O3 cathode.
Optimizing the Intermediates Adsorption by Manipulating the Second Coordination Shell of Ir Single Atoms for Efficient Water Oxidation
Authors: Wei Jie , Tang Hua , Liu Yan , Liu Guiliang , Sheng Li , Fan Minghui , Ma Yiling , Zhang Zhirong , Zeng Jie 
Published: July 2024

AbstractThe precise regulation of single‐atom catalysts (SACs) with the desired local chemical environment is vital to elucidate the relationship between the SACs structure and the catalytic performance. The debate on the effect of the local coordination environment is quite complicated even for the SACs with the same composition and chemical nature, calling for increased attention on the regulation of the second coordination shell. For oxide‐supported SACs, it remains a significant challenge to precisely manipulate the second coordination shell of single atoms supported on oxides due to the structural robustness of oxides. Here, Ir single atoms were anchored on NiO supports via different bonding strategies, resulting in the diverse Ir−O−Ni coordination numbers for Ir sites. Specifically, Ir1/NiO, Ir1−NiO, and Ir1@NiO SACs with increasing Ir−O−Ni coordination numbers of 3, 4, and 5 were synthesized, respectively. We found that the activity of the three samples towards oxygen evolution reaction (OER) exhibited a volcano‐shaped relationship with the Ir−O−Ni coordination number, with Ir1−NiO showing the lowest overpotential of 225 mV at 10 mA cm−2. Mechanism investigations indicate that the moderate coordination number of Ir−O−Ni in Ir1−NiO creates the higher occupied Ir dz2 orbital, weakening the adsorption strength for *OOH intermediates and thereby enhancing the OER activity.
Near–Infrared Heptamethine Cyanine Photosensitizers with Efficient Singlet Oxygen Generation for Anticancer Photodynamic Therapy
Authors: Liu Wenkai , He Shan , Ma Xue , Lv Chengyuan , Gu Hua , Cao Jianfang , Du Jianjun , Sun Wen , Fan Jiangli , Peng Xiaojun 
Published: July 2024

AbstractNear‐infrared photosensitizers are valuable tools to improve treatment depth in photodynamic therapy (PDT). However, their low singlet oxygen (1O2) generation ability, indicated by low 1O2 quantum yield, presents a formidable challenge for PDT. To overcome this challenge, the heptamethine cyanine was decorated with biocompatible S (Scy7) and Se (Secy7) atom. We observe that Secy7 exhibits a redshift in the main absorption to ~840 nm and an ultra‐efficient 1O2 generation capacity. The emergence of a strong intramolecular charge transfer effect between the Se atom and polymethine chain considerably narrows the energy gap (0.51 eV), and the heavy atom effect of Se strengthens spin–orbit coupling (1.44 cm−1), both of which greatly improved the high triplet state yield (61 %), a state that determines the energy transfer to O2. Therefore, Secy7 demonstrated excellent 1O2 generation capacity, which is ~24.5‐fold that of indocyanine green, ~8.2‐fold that of IR780, and ~1.3‐fold that of methylene blue under low‐power‐density 850 nm irradiation (5 mW cm−2). Secy7 exhibits considerable phototoxicity toward cancer cells buried under 12 mm of tissue. Nanoparticles formed by encapsulating Secy7 within amphiphilic polymers and lecithin, demonstrated promising antitumor and anti‐pulmonary metastatic effects, exhibiting remarkable potential for advancing PDT in deep tissues.
Integration of Perylene Diimide into a Covalent Organic Framework for Photocatalytic Oxidation
Authors: Li Zhenping , Jiao Junqiang , Fu Wenlong , Gao Ke , Peng Xinyuan , Wang Zhiwei , Zhuo Huagui , Yang Chao , Yang Mingyu , Chang Gang , Yang Lei , Zheng Xinglong , Yan Yang , Chen Feng , Zhang Mingming , Meng Zheng , Shang Xiaobo 
Published: July 2024

AbstractPerylene diimides (PDIs) have garnered considerable attention due to their immense potential in photocatalysis. However, manipulating the molecular packing within their aggregates and enhancing the efficiency of photogenerated carrier recombination remain significant challenges. In this study, we demonstrate the incorporation of a PDI unit into a covalent organic framework (COF), named PDI‐PDA, by linking an ortho‐substituted PDI with p‐phenylenediamine (PDA) to control its intermolecular aggregation. The incorporation enables precise modulation of electron‐transfer dynamics, leading to a ten‐fold increase in the efficiency of photocatalytic oxidation of thioether to sulfoxide with PDI‐PDA compared to the PDI molecular counterpart, with yields exceeding 90 %. Electron property studies and density functional theory calculations show that the PDI‐PDA with its well‐defined crystal structure, enhances π–π stacking and lowers the electron transition barrier. Moreover, the strong electron‐withdrawing ability of the PDI unit promotes the spatial separation of the valency band maximum and conduction band minimum of PDI‐PDA, suppressing the rapid recombination of photogenerated electron‐hole pairs and improving the charge‐separation efficiency to give high photocatalytic efficiency. This study provides a brief but effective way for improving the photocatalytic efficiency of commonly used PDI‐based dyes by integrating them into a framework skeleton.
Development of Organ Targeting Lipid Nanoparticles with Low Immunogenicity and Their Application in the Treatment of Pulmonary Fibrosis
Authors: Cheng Meiqi , Yu Xinyang , Qi Shaolong , Yang Kai , Lu Meixin , Cao Fangfang , Yu Guocan 
Published: July 2024

AbstractAs the most advanced non‐viral delivery system, lipid nanoparticles (LNPs) were approved by the FDA, propelling the advancements of gene therapy. However, their clinical applications are hampered by the potential immunogenicity of the lipid components that trigger immune‐related adverse events, like inflammation and allergy. Herein, we formulate various dLNPs with diminished immunogenicity by incorporating dexamethasone (Dex) into liver‐, spleen‐, and lung‐targeting LNPs formulations that exhibit excellent abilities to target specific organs and deliver various types of RNA, such as mRNA and siRNA. In vivo investigations demonstrate unparalleled advantages in safety as compared to conventional LNPs, showing promising potential in the development of RNA therapeutics. Intriguingly, the encapsulation of runt‐related transcription factor‐1 siRNA (siRUNX1) into lung‐targeting dLNPs (dLNPs@siRUNX1) demonstrates remarkable advantages in the treatment of pulmonary fibrosis through the synergy of gene therapy and drug therapy. This research establishes secure and universal platforms for the precise delivery of nucleic acid therapeutics, showcasing promising clinical applications in gene therapy.
Tail‐approach based design, synthesis, and molecular modeling of benzenesulfonamides carrying thiadiazole and urea moieties as novel carbonic anhydrase inhibitors
Authors: Han M. İhsan , Gündüz Miyase Gözde , Ammara Andrea , Supuran Claudiu T. , Doğan Şengül Dilem 
Published: July 2024

AbstractWe synthesized herein 16 compounds (SUT1–SUT16) as potential carbonic anhydrase (CA) inhibitors utilizing the tail‐approach design. Based on this strategy, we connected benzenesulfonamide, the zinc‐binding scaffold, to different urea moieties with the 1,3,4‐thiadiazole ring as a linker. We obtained the target compounds by the reaction of 4‐(5‐amino‐1,3,4‐thiadiazol‐2‐yl)benzenesulfonamide with aryl isocyanates. Upon confirmation of their structures, the compounds were screened for their ability to inhibit the tumor‐related human (h) isoforms human carbonic anhydrase (hCA) IX and XII, as well as the physiologically dominant hCA I and II. Most of the molecules demonstrated Ki values ≤ 10 nM with different selectivity profiles. The binding modes of SUT9, SUT10, and SUT5, the most effective inhibitors of hCA II, IX, and XII, respectively, were predicted by molecular docking. SUT16 (4‐{5‐[3‐(naphthalen‐1‐yl)ureido]‐1,3,4‐thiadiazol‐2‐yl}benzenesulfonamide) was found to be the most selective inhibitor of the cancer‐associated isoforms hCA IX and XII over the off‐target isoforms, hCAI and II. The interaction dynamics and stability of SUT16 within hCA IX and XII were investigated by molecular dynamics simulations as well as dynophore analysis. Based on computational data, increased hydrophobic contacts and hydrogen bonds in the tail part of these molecules within hCA IX and XII were found as favorable interactions leading to effective inhibitors of cancer‐related isoforms.
Paper‐Like 100 % Si Nanowires Electrodes Integrated with Argyrodite Li6PS5Cl Solid Electrolyte
Authors: Sánchez‐Ahijón Elena , Pendashteh Afshin , Vilatela Juan J. 
Published: July 2024

AbstractSilicon anodes are a promising solution in all‐solid‐state batteries (ASSBs) due to minor lithium dendrite risk, high capacity, and low potential. Research on Si integration in ASSBs is still nascent, requiring a deep understanding of the interplay between electrode composition, structure, and performance. Here, we present the first study on 100 % Si nanowires integrated with Li6PS5Cl solid electrolyte (SE). The anodes are paper‐like networks of aggregated Si nanowires produced by a slurry‐free method without carbon/binders. Despite the lack of any conductor, the Si anodes provide >2.5 Ah/g capacity at a high mass loading of 1.7 mg/cm2(~5 mAh/cm2), demonstrating sufficient electric and ionic conductivities. Electro‐chemo‐mechanical properties of the electrodes over (de)lithiation were probed through electrochemical impedance spectroscopy, ex‐situ microscopy, and in‐operando pressure regulation measurements. The lithiated electrode/SE interface was found to be electrochemically stable. Cross‐sectional microscopy at various states‐of‐charge confirmed the buffering effect of the anode porosity, resulting in the preservation of the electrode's thickness after the first lithiation but a considerable shrinkage during delithiation, producing cracking and formation of the new interface. Capacity remains constant for five cycles, then decreases linearly up to 40 cycles. This is attributed to repeated fracture of the anode/electrolyte interface and the corresponding impedance increase.
Can the teaching style reduce inequality in the classroom? Evidence from a quasi‐experiment
Authors: Xu Lei , Tani Massimiliano , Zhu Yu 
Published: July 2024

AbstractWe investigate the effects of ‘lecture‐based’ (LBT)—i.e. individual work and rote learning—vs. ‘discussion‐based’ (DBT)—i.e. participative and focused on student‐centred learning—teaching styles on the test scores and socio‐economic inequality of middle‐school students randomly assigned to classes using data from the China Education Panel Survey—a large‐scale nationally representative survey. Estimates from unconditional quantile regressions and decompositions based on the recentred influence function suggest that LBT raises scores in mathematics, but the effect is non‐linear, as students in the bottom and top quintiles are more likely to benefit from it. In contrast, LBT lowers scores in Chinese and English. Lecture‐based teaching also has greater influence on socio‐economically advantaged students, resulting in larger inequality within classrooms, especially between top and median students. These effects arise under various robustness checks, implying that (i) teaching styles affect scores and classroom inequality and (ii) they appear to be subject‐specific. These results suggest that teaching styles can be used as a tool to influence students’ academic performance as well as the socio‐economic heterogeneity that they bring to their classrooms.
Potential role of the methanolic extract for Olea europaea (stem and leaves) on sporulation of Eimeria papillata oocysts: In vitro study
Authors: Al‐Shaebi Esam M. , Al‐Quraishy Saleh , Abdel‐Gaber Rewaida 
Published: July 2024

AbstractMany plants are efficient anticoccidial agents owing to their content of active chemicals. Drug‐resistant Eimeria species have emerged as a result of excessive drug use. The current work aimed to investigate the oocysticidal activity (Eimeria papillata) of Olea europaea stem extract (OESE) and leaf extract (OELE) in vitro. The results of gas chromatography–mass spectrometry analysis for OELE and OESE showed the presence of 12 and 9 phytochemical compounds, respectively. Also, chemical examination revealed that the plant extracts are rich in phenols, flavonoids and tannins. Additionally, the best radical scavenging activity of OESE and OELE was at a concentration of 100 μg/ml, reaching 92.04 ± 0.02 and 92.4 ± 0.2%, respectively. The in vitro study revealed that concentrations of 200 mg/ml from OESE and OELE caused significant inhibition (100%) of process sporulation for E. papillata oocysts, in contrast to the other commercial products, which displayed varying degrees of suppression sporulation. Our findings showed that OESE and OELE have anticoccidial activity, which motivates further the conduction of in vivo studies in the search for a less expensive and more efficient cure.
Development of a biocompatible 3D hydrogel scaffold using continuous liquid interface production for the delivery of cell therapies to treat recurrent glioblastoma
Authors: Kass Lauren , Thang Morrent , Zhang Yu , DeVane Cathleen , Logan Julia , Tessema Addis , Perry Jillian , Hingtgen Shawn 
Published: July 2024

AbstractGlioblastoma (GBM) is the most common primary malignant brain tumor diagnosed in adults, carrying with it an extremely poor prognosis and limited options for effective treatment. Various cell therapies have emerged as promising candidates for GBM treatment but fail in the clinic due to poor tumor trafficking, poor transplantation efficiency, and high systemic toxicity. In this study, we design, characterize, and test a 3D‐printed cell delivery platform that can enhance the survival of therapeutic cells implanted in the GBM resection cavity. Using continuous liquid interface production (CLIP) to generate a biocompatible 3D hydrogel, we demonstrate that we can effectively seed neural stem cells (NSCs) onto the surface of the hydrogel, and that the cells can proliferate to high densities when cultured for 14 days in vitro. We show that NSCs seeded on CLIP scaffolds persist longer than freely injected cells in vivo, proliferating to 20% higher than their original density in 6 days after implantation. Finally, we demonstrate that therapeutic fibroblasts seeded on CLIP more effectively suppress tumor growth and extend survival in a mouse model of LN229 GBM resection compared to the scaffold or therapeutic cells alone. These promising results demonstrate the potential to leverage CLIP to design hydrogels with various features to control the delivery of different types of cell therapies. Future work will include a more thorough evaluation of the immunological response to the material and improvement of the printing resolution for biocompatible aqueous resins.
Acetylene Hydrogenation Processes Studied Using CFD in a Packed Bed Reactor
Authors: Guo Zhixin , Xin Siying , Du Du Chongpeng , Yao Hedan , Pan Liuyi , Lu Chenyang , Li Dong 
Published: July 2024

AbstractAcetylene hydrogenation reactions (AHR) are typically carried out in fixed bed reactors (FBRs) with high diameter‐to‐particle diameter (D/d). In this study, first, a real catalyst bed was built using the discrete element method, and the suitability of the bed was assessed using empirical equations. Second, a discrete element method‐computational fluid dynamics (DEM‐CFD) model was developed using CFD in conjunction with the reaction mechanism to simulate the AHR in the FBR and was compared with the experimental results. The results show that the DEM‐CFD can well predict the 3D interactions of velocity, temperature, and species for different D/d. The results can provide favorable theoretical guidance for the optimization of FBR and process intensification.
Self‐Assembly of Chemically Programmed Amphiphiles into Aqueous Nanotubes with a Lipophilic Lumen
Authors: Aparicio Fátima , Sancho‐Casado Irene , Chamorro Paula B. , González‐Sánchez Marina , Pujals Silvia , Vega‐Mayoral Victor , González‐Rodríguez David 
Published: July 2024

AbstractThe creation of complex hollow nanostructures with precise control over size and shape represents a great challenge in supramolecular soft materials. Here, we have further developed a bioinspired methodology for the formation of aqueous nanotubes of well‐defined dimensions and pore coating through the self‐assembly of amphiphiles that are chemically programmed with complementary nucleobases. These nanotubes are endowed with a hydrophobic lumen, whose diameter can be expanded as a function of the monomer length, in which apolar dyes can be efficiently encapsulated.
The application of aptamers in the field of aging and age‐related diseases
Authors: Xu LiuJun , Jiang Beier , Qiu WenJing , Jiang Chunxia , Zhang Feng , Tan Weihong 
Published: July 2024

AbstractThe world is transitioning into an aging society, a phenomenon that escalates the risk of age‐related diseases, posing a significant threat to human health. Addressing how to delay aging or achieve healthy aging has become an urgent and pivotal issue. Presently, diverse anti‐aging drugs are under development and entering clinical validation stages. However, the absence of specific aging biomarkers has hindered the identification of corresponding targets for diagnosing and treating aging and age‐related diseases. Aptamer, a novel molecular recognition tool, has found broad application in diagnosing and treating various diseases. Additionally, cell‐based selection holds the potential to identify unidentified molecules that could serve as biomarkers for diseases. Recent years have seen a surge in attention towards aging and age‐related diseases, with the application of aptamer in this domain rapidly advancing. Consequently, this review will provide a concise overview of the aging, with a focus on the utilisation of aptamer in aging and age‐related diseases.