bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wild and banal: the value of the arts as commons
Authors: Johanson Katya 
Published: July 2015

Purpose– The purpose of this paper is to identify the value of the arts play in public spaces in replicating a contemporary commons.Design/methodology/approach– The study is an exploratory investigation which uses a case study of cultural events in public parks – the Vancouver Parks Board’s fieldhouse residency program (2012-2015). The study uses content analysis of the social media sites created for these projects to identify how the sites and the cultural events were valued by stakeholders and participants.Findings– The paper finds that, in combination, the park events and the social media discussion of them function as a form of the commons, in which new urban communities are formed or defined around specific common social interests.Research limitations/implications– The paper finds that, in combination, the park events and the reflective engagement prompted by the social media discussion of them function as a form of the commons, in which new urban communities are formed or defined around specific common social interests.Practical implications– It is anticipated that cultural programs will increasingly interact with common public places.Social implications– The study supports the increased use of and recognition of public places as culturally significant.Originality/value– The study aims to encourage the expansion of arts and cultural policy and programs to incorporate common public places.
Le complémentaire des puissances -ièmes dans un corps de nombres est un ensemble diophantien
Authors: Colliot-Thélène Jean-Louis , Van Geel Jan 
Published: July 2015

For $n=2$ the statement in the title is a theorem of B. Poonen (2009). He uses a one-parameter family of varieties together with a theorem of Coray, Sansuc and one of the authors (1980), on the Brauer–Manin obstruction for rational points on these varieties. For $n=p$, $p$ any prime number, A. Várilly-Alvarado and B. Viray (2012) considered analogous families of varieties. Replacing this family by its $(2p+1)$th symmetric power, we prove the statement in the title using a theorem on the Brauer–Manin obstruction for rational points on such symmetric powers. The latter theorem is based on work of one of the authors with Swinnerton-Dyer (1994) and with Skorobogatov and Swinnerton-Dyer (1998), work generalising results of Salberger (1988).
Draft Genome Sequence of a Highly Virulent Rabbit Staphylococcus aureus Strain
Authors: Német Zoltán , Albert Ervin , Nagy Tibor , Olasz Ferenc , Barta Endre , Kiss János , Dán Ádám , Bányai Krisztián , Hermans Katleen , Biksi Imre 
Published: July 2015

ABSTRACT

We report the draft genome sequence of
Staphylococcus aureus
Sp17, a typical highly virulent (HV) rabbit strain. As current medicine apparently fails to effectively reduce disease and economical losses caused by this organism, it is essential to gain better insight on its genomic arrangement.
Complete Genome Sequences of Serotype O Foot-and-Mouth Disease Viruses Recovered from Experimental Persistently Infected Cattle
Authors: Parthiban AravindhBabu R. , Mahapatra Mana , Parida Satya 
Published: July 2015

ABSTRACT
For the first time, the complete genome sequences of the six serotype O foot-and-mouth disease viruses from persistently infected carrier cattle are reported here. No consistent amino acid changes were found in these viruses obtained from persistently infected cattle compared with the complete genome of the parent virus that was used to infect the cattle.
Draft Genome Sequence of Microvirga vignae Strain BR 3299
T
, a Novel Symbiotic Nitrogen-Fixing Alphaproteobacterium Isolated from a Brazilian Semiarid Region
Authors: Zilli Jerri Edson , Passos Samuel Ribeiro , Leite Jakson , Xavier Gustavo Ribeiro , Rumjaneck Norma Gouvea , Simoes-Araujo Jean Luiz 
Published: July 2015

ABSTRACT

Microvirga vignae
is a recently described species of root-nodule bacteria isolated from cowpeas grown in a Brazilian semiarid region. We report here the 6.4-Mb draft genome sequence and annotation of
M. vignae
type strain BR 3299. This genome information may help to understand the mechanisms underlying the ability of the organism to grow under drought and high-temperatures conditions.
Complete Genome Sequence of Tomato Mosaic Virus Isolated from Jasmine in the United States
Authors: Fillmer Kornelia , Adkins Scott , Pongam Patchara , D’Elia Tom 
Published: July 2015

ABSTRACT
Tomato mosaic virus was reported from jasmine in Florida. We present the first complete genome sequence of a tomato mosaic virus isolate from this woody perennial plant in the United States.
Complete Genome Sequence of Pragia fontium 24613, an Environmental Bacterium from the Family
Enterobacteriaceae
Authors: Snopková Kateřina , Sedlář Karel , Bosák Juraj , Chaloupková Eva , Provazník Ivo , Šmajs David 
Published: July 2015

ABSTRACT

The complete genome sequence of
Pragia fontium
24613 was determined using PacBio RSII, Roche 454, and SOLiD sequencing. A total of 3,579 genes were predicted, including 3,338 protein-coding sequences and 146 pseudogenes. This is the first whole-genome sequence of a strain belonging to the environmental genera of the family
Enterobacteriaceae
.
Full-Genome Sequence of a Novel Varicella-Zoster Virus Clade Isolated in Mexico
Authors: Garcés-Ayala Fabiola , Rodríguez-Castillo Araceli , Ortiz-Alcántara Joanna María , Gonzalez-Durán Elizabeth , Segura-Candelas José Miguel , Pérez-Agüeros Sandra Ivette , Escobar-Escamilla Noé , Méndez-Tenorio Alfonso , Diaz-Quiñonez José Alberto , Ramirez-González José Ernesto 
Published: July 2015

ABSTRACT

Varicella-zoster virus (VZV) is a member of the
Herpesviridae
family, which causes varicella (chicken pox) and herpes zoster (shingles) in humans. Here, we report the complete genome sequence of varicella-zoster virus, isolated from a vesicular fluid sample, revealing the circulation of VZV clade VIII in Mexico.
Whole-Genome Sequences of Multidrug-Resistant Escherichia coli Strains Sharing the Same Sequence Type (ST410) and Isolated from Human and Avian Sources in Italy
Authors: Giufré Maria , Accogli Marisa , Graziani Caterina , Busani Luca , Cerquetti Marina 
Published: July 2015

ABSTRACT

Extraintestinal pathogenic
Escherichia coli
(ExPEC) is involved in a wide spectrum of human diseases. Chickens have been suggested as reservoirs for fluoroquinolone (FQ)-resistant ExPEC strains. Here, we report the whole-genome sequences of 4
E. coli
strains sharing the same sequence type (ST) (ST410) and that were isolated from human and avian sources in Italy.
Draft Genome Sequences of the Two Unrelated Macrolide-Resistant Corynebacterium argentoratense Strains CNM 463/05 and CNM 601/08, Isolated from Patients in the University Hospital of León, Spain
Authors: Fernández-Natal Maria Isabel , Soriano Francisco , Acedo Alberto , Hernandez Marta , Tauch Andreas , Rodríguez-Lázaro David 
Published: July 2015

ABSTRACT

Corynebacterium argentoratense
has been associated mainly with infections in the human respiratory tract. Genome sequencing of two unrelated clinical macrolide-resistant strains, CNM 463/05 and CNM 601/08, revealed the presence of the antibiotic resistance gene
erm
(X) allocated to a specific genomic region with 100% similarity to the widely distributed transposable element Tn
5432.
Complete Genome Sequence of Mycoplasma hominis Strain Sprott (ATCC 33131), Isolated from a Patient with Nongonococcal Urethritis
Authors: Calcutt Michael J. , Foecking Mark F. 
Published: July 2015

ABSTRACT

Presented here is the complete and annotated genome sequence of
Mycoplasma hominis
Sprott (ATCC 33131). The chromosome comprises 695,214 bp, which is approximately 30 kb larger than the syntenic genome of
M. hominis
PG21
T
. Tetracycline resistance of strain Sprott is most probably conferred by the
tetM
determinant, harbored on a mosaic transposon-like structure.
To tweet or not to tweet about schizophrenia systematic reviews (TweetSz): study protocol for a randomised controlled trial
Authors: Jayaram Mahesh , Bodart Angelique Y M , Sampson Stephanie , Zhao Sai , Montgomery Alan A , Adams Clive E 
Published: July 2015

IntroductionThe Cochrane Schizophrenia Group (CSzG) has produced and maintained systematic reviews of effects of interventions for schizophrenia and related illness. Each review has a Plain Language Summary (PLS), for those without specialised knowledge, and an abstract, which are freely available from The Cochrane Library (https://summaries.cochrane.org). Increasingly, evidence is being distributed using social media such as Twitter and Weibo (in China) alongside traditional publications.Methods and analysisIn a prospective two-arm, parallel, open randomised controlled trial with a 1:1 allocation ratio, we will allocate 170 published systematic reviews into the intervention group (tweeting arm/Weibo arm) versus the control group (non-tweeting arm). Reviews will be stratified by baseline access activity, defined as high (≥19 views per week, n=14), medium (4.3 to 18.99 views per week, n=72) or low (<4.3 views per week, n=84), based on Google Analytics, which will also be used for evaluating outcomes. The intervention group will have three tweets daily using Hootsuite with a slightly different accompanying text (written by CEA and AB) and a shortened Uniform Resource Locator (URL) to the PLS: a) The review title as it appears in summaries.cochrane.org, b) A pertinent extract from results or discussion sections of the abstract and c) An intriguing question or pithy statement related to the evidence in the abstract. The primary outcome will be: total number of visits to a PLS in 7 days following the tweet. Secondary outcomes will include % new visits, bounce rate, pages per visit, visit duration, page views, unique page views, time on page, entrances, exiting behaviour and country distribution.Ethics and disseminationThis study does not involve living participants, and uses information available in the public domain. Participants arepublished systematic reviews,hence, no ethical approval is required. Dissemination will be via Twitter, Weibo and traditional academic means.Trial registration numberISRCTN84658943.
A Strategic Roadmap for Navigating Academic-Industry Collaborations in Information Systems Research
Authors: Marcolin Barbara L. , Saunders W. Chad 
Published: July 2015

Research collaboration between industry and academia remains challenging despite progress being made on a number of fronts. We are not implying that all information systems researchers should be engaging in industry collaborations, nor should the value of critique and work exclusively addressing academic and other audiences be viewed as less valuable than those engaging industry. The intent is instead to encourage more industry collaboration, and for those considering such initiatives to roadmap the activities strategically giving consideration to the full range of activities required so reasonable tradeoffs can be made in the context of building longer-term sustainable relationships.
We develop a roadmap from literature that organizes the building blocks (component activities) needed to plan and implement strategic academic-industry collaborations over longer time horizons. Specifically, we identify the key themes or layers of (1) Strategic Business Problem(s), (2) Governance, (3) Funding Criteria, (4) Privacy, Security and Ethics, (5) Intellectual Property, (6) Research Design and (7) Recognized Outputs, which need to be in place if you are to succeed with academic-industry research.
The roadmap framework highlights the need to consider the implications of the components across each of the layers at a particular point in time (vertical slice), the relationship between layers (dependencies) and the need for aligning the various activities in a coordinated manner; otherwise success at one layer is often undermined by a lack of awareness or failure at another layer.
Our hope is that these themes (layers) facilitate organizing this collaboration in a systematic and coordinated manner to produce academic-industry collaborations that progressively improve over time.
Effects of Extended-Release Nicotinic Acid on Apolipoprotein (a) Kinetics in Hypertriglyceridemic Patients
Authors: Croyal Mikaël , Ouguerram Khadija , Passard Maxime , Ferchaud-Roucher Véronique , Chétiveaux Maud , Billon-Crossouard Stéphanie , de Gouville Anne-Charlotte , Lambert Gilles , Krempf Michel , Nobécourt Estelle 
Published: July 2015

Objective—
To determine the mechanisms by which extended-release nicotinic acid reduces circulating lipoprotein (a) concentrations in hypertriglyceridemic patients.

Approach and Results—

Eight nondiabetic, obese male subjects (aged 48±12 years; body mass index, 31.2±1.8 kg/m
2
) with hypertriglyceridemia (triglycerides, 226±78 mg/dL) were enrolled in an 8 week, double blind, placebo-controlled cross-over study. At the end of each treatment phase, fasted subjects received a 10 µmol/L per kg bolus injection of [5,5,5-
2
H
3
]-
l
-Leucine immediately followed by constant infusion of [5,5,5-
2
H
3
]-
l
-Leucine (10 µmol L
−1
kg
−1
h
−1
) for 14 hours, and blood samples were collected. A liquid chromatography–tandem mass spectrometry method was used to study apolipoprotein (a) (Apo(a)) kinetics. The fractional catabolic rate of Apo(a) was calculated with a single compartmental model using the apolipoprotein B100 (ApoB100) containing very low density lipoprotein tracer enrichment as a precursor pool. Extended-release nicotinic acid decreased plasma triglycerides (−46%;
P
=0.023), raised high-density lipoprotein cholesterol (+20%;
P
=0.008), and decreased Apo(a) plasma concentrations (−20%;
P
=0.008). Extended-release nicotinic acid also decreased ApoB100 (22%;
P
=0.008) and proprotein convertase subtilisin/kexin type 9 (PCSK9, −29%;
P
=0.008) plasma concentrations. Apo(a) fractional catabolic rate and production rates were decreased by 37% (0.58±0.28 versus 0.36±0.19 pool/d;
P
=0.008) and 50% (1.4±0.8 versus 0.7±0.4 nmol/kg per day;
P
=0.008), respectively.

Conclusions—
Extended-release nicotinic acid treatment decreased Apo(a) plasma concentrations by 20%, production rates by 50%, and catabolism by 37%. ApoB100 and PCSK9 concentrations were also decreased by treatment, but no correlation was found with Apo(a) kinetic parameters.
Contribution of Rare and Common Genetic Variants to Plasma Lipid Levels and Carotid Stiffness and Geometry
Authors: Proust Carole , Empana Jean-Philippe , Boutouyrie Pierre , Alivon Maureen , Challande Pascal , Danchin Nicolas , Escriou Guillaume , Esslinger Ulrike , Laurent Stéphane , Li Zhenlin , Pannier Bruno , Regnault Veronique , Thomas Frederique , Jouven Xavier , Cambien François , Lacolley Patrick 
Published: July 2015

Background—
We assess the contribution of common and rare putatively functional genetic variants (most of them coding) present on the Illumina exome Beadchip to the variability of plasma lipids and stiffness of the common carotid artery.

Methods and Results—

Measurements were obtained from 2283 men and 1398 women, and after filtering and exclusion of monomorphic variants, 32 827 common (minor allele frequency >0.01) and 68 770 rare variants were analyzed. A large fraction of the heritability of plasma lipids is attributable to variants present on the array, especially for triglycerides (fraction of variance attributable to measured genotypes:
V
(G)/
V
p
=31.4%,
P
<3.1×10
–11
) and high-density lipoprotein cholesterol (
V
(G)/
V
p
=26.4%,
P
<4.2×10
–12
). Plasma lipids were associated with common variants located in known candidate genes, but no implication of rare variants could be established. Gene sets for plasma lipids, blood pressure, and coronary artery disease were defined on the basis of recent meta-analyses of genome-wide association studies. We observed a strong association between the plasma lipids gene set and plasma lipid variables, but none of the 3 genome-wide association studies gene sets was associated with the carotid parameters. Significant
V
(G)/
V
p
ratios were observed for external (14.5%,
P
<2.7×10
–5
) and internal diameter (13.4%,
P
<4.3×10
–4
), stiffness (12.5%,
P
<8.0×10
–4
), intima-media thickness (10.6%,
P
<7.9×10
–4
), and wall cross-sectional area (13.2%,
P
<2.4×10
–5
). A significant association was observed between the common rs2903692 polymorphism of the
CLEC16A
gene and the internal diameter (
P
<4.3×10
–7
).

Conclusions—

These results suggest an involvement of
CLEC16A
, a gene that has been reported to be associated with immune disorders, in the modulation of carotid vasodilatation.
Embolic Strokes of Undetermined Source in the Athens Stroke Registry
Authors: Ntaios George , Papavasileiou Vasileios , Milionis Haralampos , Makaritsis Konstantinos , Vemmou Anastasia , Koroboki Eleni , Manios Efstathios , Spengos Konstantinos , Michel Patrik , Vemmos Konstantinos 
Published: July 2015

Background and Purpose—
Information about outcomes in Embolic Stroke of Undetermined Source (ESUS) patients is unavailable. This study provides a detailed analysis of outcomes of a large ESUS population.

Methods—
Data set was derived from the Athens Stroke Registry. ESUS was defined according to the Cryptogenic Stroke/ESUS International Working Group criteria. End points were mortality, stroke recurrence, functional outcome, and a composite cardiovascular end point comprising recurrent stroke, myocardial infarction, aortic aneurysm rupture, systemic embolism, or sudden cardiac death. We performed Kaplan–Meier analyses to estimate cumulative probabilities of outcomes by stroke type and Cox-regression to investigate whether stroke type was outcome predictor.

Results—
2731 patients were followed-up for a mean of 30.5±24.1months. There were 73 (26.5%) deaths, 60 (21.8%) recurrences, and 78 (28.4%) composite cardiovascular end points in the 275 ESUS patients. The cumulative probability of survival in ESUS was 65.6% (95% confidence intervals [CI], 58.9%–72.2%), significantly higher compared with cardioembolic stroke (38.8%, 95% CI, 34.9%–42.7%). The cumulative probability of stroke recurrence in ESUS was 29.0% (95% CI, 22.3%–35.7%), similar to cardioembolic strokes (26.8%, 95% CI, 22.1%–31.5%), but significantly higher compared with all types of noncardioembolic stroke. One hundred seventy-two (62.5%) ESUS patients had favorable functional outcome compared with 280 (32.2%) in cardioembolic and 303 (60.9%) in large-artery atherosclerotic. ESUS patients had similar risk of composite cardiovascular end point as all other stroke types, with the exception of lacunar strokes, which had significantly lower risk (adjusted hazard ratio, 0.70 [95% CI, 0.52–0.94]).

Conclusions—
Long-term mortality risk in ESUS is lower compared with cardioembolic strokes, despite similar rates of recurrence and composite cardiovascular end point. Recurrent stroke risk is higher in ESUS than in noncardioembolic strokes.
Genetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke
Authors: Hanscombe Ken B. , Traylor Matthew , Hysi Pirro G. , Bevan Stephen , Dichgans Martin , Rothwell Peter M. , Worrall Bradford B. , Seshadri Sudha , Sudlow Cathie ,   the METASTROKE Consortium,   the Wellcome Trust Case Control Consortium 2, Williams Frances M.K. , Markus Hugh S. , Lewis Cathryn M. 
Published: July 2015

Background and Purpose—
Abnormal coagulation has been implicated in the pathogenesis of ischemic stroke, but how this association is mediated and whether it differs between ischemic stroke subtypes is unknown. We determined the shared genetic risk between 14 coagulation factors and ischemic stroke and its subtypes.

Methods—
Using genome-wide association study results for 14 coagulation factors from the population-based TwinsUK sample (N≈2000 for each factor), meta-analysis results from the METASTROKE consortium ischemic stroke genome-wide association study (12 389 cases, 62 004 controls), and genotype data for 9520 individuals from the WTCCC2 ischemic stroke study (3548 cases, 5972 controls—the largest METASTROKE subsample), we explored shared genetic risk for coagulation and stroke. We performed three analyses: (1) a test for excess concordance (or discordance) in single nucleotide polymorphism effect direction across coagulation and stroke, (2) an estimation of the joint effect of multiple coagulation-associated single nucleotide polymorphisms in stroke, and (3) an evaluation of common genetic risk between coagulation and stroke.

Results—

One coagulation factor, factor XIII subunit B (FXIIIB), showed consistent effects in the concordance analysis, the estimation of polygenic risk, and the validation with genotype data, with associations specific to the cardioembolic stroke subtype. Effect directions for FXIIIB-associated single nucleotide polymorphisms were significantly discordant with cardioembolic disease (smallest
P
=5.7×10
−04
); the joint effect of FXIIIB-associated single nucleotide polymorphisms was significantly predictive of ischemic stroke (smallest
P
=1.8×10
−04
) and the cardioembolic subtype (smallest
P
=1.7×10
−04
). We found substantial negative genetic covariation between FXIIIB and ischemic stroke (rG=−0.71,
P
=0.01) and the cardioembolic subtype (rG=−0.80,
P
=0.03).

Conclusions—
Genetic markers associated with low FXIIIB levels increase risk of ischemic stroke cardioembolic subtype.
Resveratrol Preconditioning Induces a Novel Extended Window of Ischemic Tolerance in the Mouse Brain
Authors: Koronowski Kevin B. , Dave Kunjan R. , Saul Isabel , Camarena Vladimir , Thompson John W. , Neumann Jake T. , Young Juan I. , Perez-Pinzon Miguel A. 
Published: July 2015

Background and Purpose—
Prophylactic treatments that afford neuroprotection against stroke may emerge from the field of preconditioning. Resveratrol mimics ischemic preconditioning, reducing ischemic brain injury when administered 2 days before global ischemia in rats. This protection is linked to silent information regulator 2 homologue 1 (Sirt1) and enhanced mitochondrial function possibly through its repression of uncoupling protein 2. Brain-derived neurotrophic factor (BDNF) is another neuroprotective protein associated with Sirt1. In this study, we sought to identify the conditions of resveratrol preconditioning (RPC) that most robustly induce neuroprotection against focal ischemia in mice.

Methods—
We tested 4 different RPC paradigms against a middle cerebral artery occlusion model of stroke. Infarct volume and neurological score were calculated 24 hours after middle cerebral artery occlusion. Sirt1-chromatin binding was evaluated by ChIP-qPCR. Percoll gradients were used to isolate synaptic fractions, and changes in protein expression were determined via Western blot analysis. BDNF concentration was measured using a BDNF-specific ELISA assay.

Results—
Although repetitive RPC induced neuroprotection from middle cerebral artery occlusion, strikingly one application of RPC 14 days before middle cerebral artery occlusion showed the most robust protection, reducing infarct volume by 33% and improving neurological score by 28%. Fourteen days after RPC, Sirt1 protein was increased 1.5-fold and differentially bound to the uncoupling protein 2 and BDNF promoter regions. Accordingly, synaptic uncoupling protein 2 level decreased by 23% and cortical BDNF concentration increased 26%.

Conclusions—
RPC induces a novel extended window of ischemic tolerance in the brain that lasts for at least 14 days. Our data suggest that this tolerance may be mediated by Sirt1 through upregulation of BDNF and downregulation of uncoupling protein 2.