bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fertility Preservation Success Subsequent to Concurrent Aromatase Inhibitor Treatment and Ovarian Stimulation in Women With Breast Cancer
Authors: Oktay Kutluk , Turan Volkan , Bedoschi Giuliano , Pacheco Fernanda S. , Moy Fred 
Published: June 2015

Purpose We have previously reported an approach to ovarian stimulation for the purpose of fertility preservation (FP) in women with breast cancer via embryo freezing with the concurrent use of letrozole. The aim of this study was to provide the pregnancy and FP outcomes when embryos generated with the same protocol are used. Patients and Methods In all, 131 women with stage ≤ 3 breast cancer underwent ovarian stimulation and received concurrent letrozole 5 mg per day before receiving adjuvant chemotherapy and cryopreserving embryos. Results Thirty-three of the 131 women underwent 40 attempts to transfer embryos to their own uterus (n = 18) or via the use of a gestational carrier (n = 22) at a mean age of 41.5 ± 4.3 years with a median 5.25 years after embryo cryopreservation. The overall live birth rate per embryo transfer was similar to the US national mean among infertile women of a similar age undergoing in vitro fertilization–embryo transfer (45.0 v 38.2; P = .2). Seven (38.8%) of the 18 pregnancies were twins with no higher-order pregnancies being encountered. No fetal anomalies or malformations were reported in 25 children after a mean follow-up of 40.4 ± 26.4 months. Seventeen of the 33 women attempting pregnancy had at least one child, translating into an FP rate of 51.5% per attempting woman. Conclusion Embryo cryopreservation after ovarian stimulation with the letrozole and follicle-stimulating hormone protocol preserves fertility in women with breast cancer and results in pregnancy rates comparable to those expected in a noncancer population undergoing in vitro fertilization.
A EAD NO BRASIL E A IMPORTÂNCIA DE COMPETÊNCIAS SUBJACENTES PARA O RECONHECIMENTO DE CURSOS DE ACORDO COM A PERCEPÇÃO DE COORDENADORES DE CURSO
Authors: Fiorillo Aurélio , Maccari Emerson Antonio , Martins Cibele Barsalini 
Published: June 2015

<p>A Educação a Distância (EaD) é uma importante modalidade no contexto educacional, pois, além de democratizar a educação, também contribui para a sua ampliação, uma vez que abrange cidades longínquas. O número de organizações educacionais interessadas em obter a autorização e o reconhecimento para cursos superiores de EaD vem crescendo consideravelmente. No entanto, não existem estudos sobre o instrumento de avaliação de cursos do Ministério da Educação (MEC), unificado em dezembro de 2011 e atualizado em maio de 2012. O desafio central deste trabalho foi analisar esse instrumento e identificar as competências essenciais que devem ser desenvolvidas pelas instituições, bem como ressaltar as competências que podem ser caracterizadas como distintivas por conferir vantagens competitivas. Para tanto, realizou-se uma pesquisa descritivo-exploratória, em que foi feita a escolha de uma instituição de ensino superior que estava sendo submetida ao processo de mudanças impostas pelo MEC. O resultado da pesquisa mostrou quatro principais competências organizacionais desenvolvidas na instituição, que possibilitaram a aprovação do curso pelo MEC, a saber: Gestão de Avaliação de Curso; Gestão Estratégica e de Políticas para a EaD; Gestão de Recursos Humanos e das Equipes Multidisciplinares; e Gestão e Planejamento da Infraestrutura Física e Tecnológica.</p>
Sacred Text, Social Hierarchy, World Polity: The Journey of a Single Sentence That Shaped a World Religion
Authors: Velasco Ismael 
Published: June 2015

Abstract
Among the central tropes of Baha’i socio-political theology is a single sentence from the Persian Bayan which, alluded to in Baha’u’llah’s Kitab-i Aqdas became, in Shoghi Effendi’s interpretation, the ‘myth of origin’, in the sense of a starting point in sacred narrative, for the Baha’i Administrative Order structuring the Baha’i community, and for the Baha’i World Order envisaged as its culmination, ultimate purpose and eventual fruit. The passage in question states, in Shoghi Effendi’s translation, ‘well is it with him who fixeth his gaze on the Order of Baha’u’llah’. Shoghi Effendi’s interpretation of that passage as alluding to a sacred socio-political entity which is the hallmark of the Baha’i revelation and is anticipated as the embodiment and structure of the millennial promise of the unification of humankind, represents a radical interpretive leap, given that the passage in the Persian Bayan in its most intuitive reading refers, not to an institutional idea, but to the compilation and arrangement of sacred Babi texts. At the heart of this seemingly incompatible usage lies the single word nazm, which may be translated as both order and arrangement.
The present paper will explore the interpretive trajectory of the word nazm, from its roots in the earliest Qur’anic hermeneutics dating from the 2nd Islamic century, to its complex articulation in the Bab’s writings, including various instances in the Persian Bayan and in the Kitabu’l-Asma’. It will contextualize these occurrences in the Bab’s subtle and esoteric (batini) cosmogony of the universe as Text, including the simultaneity and parallelism of levels of interpretation, within which the apparently inoccuous passage of the Bab is revealed to be charged with cosmological, communal and messianic dimensions, which it will be argued form the implicit substratum or at least demonstrate a substantive correlation to the counter-intuitive, although not exclusive interpretation of that passage by Shoghi Effendi as denoting likewise a communal, global and, in its deepest level, a messianic cosmic order.
The changing Uyghur religious soundscape
Authors: Harris Rachel 
Published: June 2015

Abstract
Recent studies in the anthropology of Islam have called for a new understanding of the relationship between global forms of Islam and local priorities, new ideologies and everyday religious experience. This article addresses these concerns in the context of Uyghur society in the Xinjiang Uyghur Autonomous Region of China where communities are increasingly engaging with transnational currents of Islamic ideology, and increasingly under pressure from the state which conflates religiosity with anti-state activity and extremist terrorism. The article focuses on Islamic media, in particular at the ways in which rural Uyghur women experience and reproduce globalized forms of Islamic media. It aims to understand how the most marginalized sectors of society are engaging with these changing religious ideologies and practices. The theoretical frame draws on notions of the ‘soundscape’, which explore the ways in which sound, practices of listening and perceptions of sound, may be central to making sense of the world around us.
Head-wagging and the sounds of obscenity: Conflicts over sound on the Qing-Muslim frontiers
Authors: Lipman Jonathan N. 
Published: June 2015

Abstract
On both the southwestern and the northwestern frontiers of their expanding empire, the eighteenth-century Qing dynasty (1636–1912) ruled over considerable numbers of Muslims. This article examines two legal cases in which Muslims sued other Muslims in a secular Qing court to resolve issues of Islamic practice that involved sound. The southwestern (Yunnan) Qalandar case (c.1710) pitted conventional imams and Sino-Muslim elites against ‘wild Sufis’ from India and northwest China. The northwestern (Gansu) litigation (1760s–1780s) was brought by two Sufi orders that claimed to practice different rituals: one silent and one vocal. In both cases, the Qing officials found themselves adjudicating accusations of Islamic heterodoxy, which they decided by analogy to Qing legal definitions of Confucian heterodoxy. Using new materials for the Gansu case, the article concludes that one of the Sufi orders manipulated the Qing officials’ ignorance of Islam, the Arabic language and Islamic sound to win a conflict that thereafter divided the region for more than a century.
Sound and silence in Chinese women’s mosques – identity, faith and equality
Authors: Jaschok Maria 
Published: June 2015

Abstract
The evolution from early beginnings of Muslim women’s religious education in China, in the seventeenth century, when women were provided with rudimentary Islamic instruction, and taught from behind screens, to the emergence of more permanent women’s mosques (qingzhen nüsi) in the course of the nineteenth century, constitutes the historical background to an exploration of the relationship among silence, speech, voice, gender and power. Starting as informal gatherings in ad hoc, transitional spaces, dynamic and complex institutional sites developed to serve multiple functions and purposes, giving in the course of time rise to richly expressive cultures of sentiment and sound, piety and fear. The article seeks to problematize the coming-to-voice of Chinese believing women within the interlinking frameworks of aural ethnography and cross-cultural feminist theory. Written and audio-visual materials provide the sensory text for the author’s evocation of tangible surroundings, silenced and fleeting sensations, and for the historicizing of women’s lives lived at the intersection of Islamic/Confucian moral codes of jie – as feminine purity enshrouded, segregated and silenced – and modern claims for voice and gender equality.
Metal bridges to probe membrane ion channel structure and function
Authors: Linsdell Paul 
Published: June 2015

AbstractIon channels are integral membrane proteins that undergo important conformational changes as they open and close to control transmembrane flux of different ions. The molecular underpinnings of these dynamic conformational rearrangements are difficult to ascertain using current structural methods. Several functional approaches have been used to understand two- and three-dimensional dynamic structures of ion channels, based on the reactivity of the cysteine side-chain. Two-dimensional structural rearrangements, such as changes in the accessibility of different parts of the channel protein to the bulk solution on either side of the membrane, are used to define movements within the permeation pathway, such as those that open and close ion channel gates. Three-dimensional rearrangements – in which two different parts of the channel protein change their proximity during conformational changes – are probed by cross-linking or bridging together two cysteine side-chains. Particularly useful in this regard are so-called metal bridges formed when two or more cysteine side-chains form a high-affinity binding site for metal ions such as Cd2+or Zn2+. This review describes the use of these different techniques for the study of ion channel dynamic structure and function, including a comprehensive review of the different kinds of conformational rearrangements that have been studied in different channel typesviathe identification of intra-molecular metal bridges. Factors that influence the affinities and conformational sensitivities of these metal bridges, as well as the kinds of structural inferences that can be drawn from these studies, are also discussed.
Unusual presentation of fetus in fetu in triplet pregnancy mimicking abdominal wall defect
Authors: Erdogdu Emre , Arısoy Resul , Kumru Pınar , Pakay Kaan , Demirci Oya , Pekin Oya , Aydin Hatip 
Published: June 2015

Abstract
Fetus in fetu (FIF) is a rare form of twinning in which an immature twin develops parasitically inside the other twin. The most frequent location of a parasitic fetus is the retroperitoneal region. A FIF located on the abdominal wall is an unusual condition, and it should be kept in mind as one of the differential diagnoses of abdominal wall masses.
A case of fetal cardiac rupture diagnosed by postmortem magnetic resonance image
Authors: Hishikawa Kenji , Wada Seiji , Ozawa Katsusuke , Matsuoka Kentaro , Miyazaki Osamu , Sago Haruhiko 
Published: June 2015

Abstract

Background: Fetal cardiac rupture is very rare and has been scarcely reported. Prenatal image diagnosis of fetal cardiac rupture is not well characterized.

Case: An 18-week fetus with a pericardial mass and effusion revealed by ultrasound was suspected to have a pericardial tumor. Fetal demise occurred at 19 weeks’ gestation. Postmortem magnetic resonance image (MRI) found a pericardial mass diagnosed as a hematoma caused by cardiac rupture. Findings were confirmed by autopsy.

Conclusion: MRI may be applicable for prenatal diagnosis of cardiac rupture.
Tapping into the wisdom in the room: results from participant discussion at the 7th International Conference on Diagnostic Error in Medicine facilitated by a World Café technique
Authors: Cosby Karen S. , Zipperer Lorri , Balik Barbara 
Published: June 2015

Abstract
The patient safety literature is full of exhortations to approach medical error from a system perspective and seek multidisciplinary solutions from groups including clinicians, patients themselves, as well as experts outside the traditional medical domain. The 7th annual International Conference on Diagnostic Error in Medicine sought to attract a multispecialty audience, and attempted to capture some of the conversations by engaging participants in a World Café, a technique used to stimulate discussion and preserve insight gained during the conference. We present the ideas generated in this session, discuss them in the context of psychological safety, and demonstrate the application of this novel technique.
Numerical computation of fractional Lotka-Volterra equation arising in biological systems
Authors: Ramswroop  , Singh Jagdev , Kumar Devendra 
Published: June 2015

AbstractIn this paper, we present the homotopy analysis transform method (HATM) to solve fractional Lotka- Volterra equation, which describes the long term servival of species. The HATM solutions, denotes less error compare with their respective exact solution for alpha = 1. In addition to non-proposed techniques, HATMis valid for both small and large parameters, it also provides us with a simpleway to adjust and control the parameter hbar and auxiliary function H(t), which play effective role for convergence solutions of fractional differential-difference equations (FDDEs).
Synthesis and superconductivity in spark plasma sintered pristine and graphene-doped FeSe0.5Te0.5
Authors: Puneet Pooja , Podila Ramakrishna , He Jian , Rao Apparao M. , Howard Austin , Cornell Nicholas , Zakhidov Anvar A. 
Published: June 2015

Abstract
Here, we present a new ball-milling and spark plasma sintering (SPS)-based technique for the facile synthesis of FeSe0.5Te0.5 superconductors without the need for pre-alloying. This method is advantageous since it is quick and flexible for incorporating other dopants such as graphene for vortex pinning. We observed that FeSe0.5Te0.5 exhibits a coexistence of ferromagnetic (FM) and superconductivity signature plausibly arising from a FM core-superconducting shell structure. More importantly, the H

c2 values observed from resistivity data are higher than 7 T, indicating that SPS process synthesized FeSe0.5Te0.5 samples could lead to next-generation superconducting wires and cables.
TSH-secreting pituitary adenoma: benefits of pre-operative octreotide
Authors: Wallace I R , Healy E , Cooke R S , Ellis P K , Harper R , Hunter S J 
Published: June 2015

Summary
TSH-secreting pituitary adenomas are rare and the optimal investigation and management is uncertain. We describe a case of a 43 year-old woman with a TSH-secreting pituitary adenoma, highlighting diagnostic testing and our use, pre-operatively of somatostatin analogue therapy, which induced biochemical euthyroidism and a reduction in tumour size.

Learning points

The differential diagnosis of the syndrome of inappropriate TSH secretion is non-thyroidal illness, medications, assay interference due to heterophilic antibodies, thyroid hormone resistance and TSH-secreting pituitary adenoma.

TRH stimulation test and triiodothyronine suppression test assist in differentiating thyroid hormone resistance and TSH-secreting pituitary adenoma.

Somatostatin analogue therapy can induce biochemical euthyroidism and reduce tumour size.
Pancreatic neuroendocrine tumors with transformation to insulinoma: an unusual presentation of a rare disease
Authors: Nahmias Avital , Grozinsky-Glasberg Simona , Salmon Asher , Gross David J 
Published: June 2015

Summary
Approximately 35% of the pancreatic neuroendocrine tumors (pNETs) are functional, the most common of which is an insulinoma. Rarely can initially nonfunctioning tumor undergo biological transformation to a hormone-secreting tumor with subsequent changes in the clinical picture. We present here three unique patients with long-standing pNETs who developed life-threatening hyperinsulinemic hypoglycemia along with tumor progression. In two of the patients, everolimus (Afinitor) was administered in an attempt to control both tumor growth and hypoglycemia. In two cases everolimus therapy resulted in the abolishment of hypoglycemia and induced significant tumor regression; however these beneficial responses were transient. These cases highlight the exceptional ability of pNETs to change biological behavior in parallel with disease progression. Our experience concurs with recently published studies demonstrating the utility of everolimus for the control of both hypoglycemia and tumor progression.

Learning points

Nonfunctional pNET can gain new features such as insulin secretion with related morbidity.

Gain of function in a previously nonfunctional pNET signifies tumor progression and is usually associated with poor prognosis.

Everolimus proved to be a viable treatment for hypoglycemia in insulinoma patients and was also proven highly effective in the patients presented here.

As disease progresses, the effect of everolimus on hypoglycemia wanes. We report for the first time the development of hypoglycemia during everolimus treatment.
TECNOLOGÍAS PARA LA REMOCIÓN DE COLORANTES Y PIGMENTOS PRESENTES EN AGUAS RESIDUALES
Authors: Barrios-Ziolo Leonardo Fabio , Gaviria-Restrepo Luisa Fernanda , Agudelo Edison Alexander , Cardona Gallo Santiago Alonso 
Published: June 2015

<p>Los colorantes y pigmentos están comenzando hacer considerados en el país como compuestos que pueden presentar características toxicológicas más allá de los aspectos estéticos en las aguas residuales. El estado del arte presenta los tratamientos más efectivos para la remoción, destrucción y mineralización de colorantes y pigmentos presentes en aguas residuales en función de las propiedades fisicoquímicas de las moléculas constituyentes. Las cinéticas de remoción de DBO<sub>5</sub>, DQO, color “real” y “aparente” en los efluentes, además de los tiempos de operación, fueron estudiadas para determinar el conjunto de tecnologías físicas, químicas, biológicas y combinadas de mayor importancia e influencia en la actualidad. Entre las tecnologías de tratamiento más relevantes se destacan los procesos de adsorción y filtración, las tecnologías avanzadas de oxidación (fotocatálisis, ozonación, fenton/UV, electrocoagulación, etc) y los procesos biológicos secuenciales (del tipo anaerobio – aerobio). Se evidenció la influencia de variables como el pH, la concentración inicial del colorante y la solubilidad, entre otras, sobre las cinéticas de remoción de colorantes específicos. </p>
A nitrogén és a réz közötti kölcsönhatás vizsgálata szabadföldi kukorica kísérletben
Authors: Kádár Imre , Csathó Péter 
Published: June 2015

Mészlepedékes csernozjom vályogtalajon beállított szabadföldi kísérletben vizs-gáltuk a NxCu elemek közötti kölcsönhatásokat 1991-ben kukoricával. A termőhely talaja a szántott rétegben 3% humuszt, 5% körüli CaCO3-ot és kb. 20% agyagot tartalmazott.
Az elemzések alapján a terület talaja jó Ca-, Mg-, K-, Mn-, kielégítő Cu-, köze-pes N-, valamint gyenge-közepes P- és Zn-ellátottságú volt. A talajvíz 13–15 m mélyen van, tehát a terület aszályérzékeny. A kísérletet 4N×3Cu = 12 kezelés × 3 ismétlés = 36 parcellával állítottuk be osztott parcellás (split-plot) elrendezéssel.
A N 0, 100, 200, 300 kg·ha−1, a Cu 0, 50, 100 kg·ha−1 adagokat jelentett Ca-ammóniumnitrát, illetve CuSO4 formájában. Az árpilis, május és a július hónapokat aszály jellemezte.
Főbb eredményeink:

1. Az 1991. év első fele erősen csapadékhiányos volt, a N-trágyázás termés-csökkenést eredményezett. Igazolhatóan mérséklődött a termő tövek száma. Az 1000-szem tömeg 278 g maradt. A Cu-trágyázással igazolhatóan emelkedett az egy tőre eső szemek száma, illetve a csövenkénti szemtömeg. A szemtermés az NxCu kezelésekben 7,0 és 8,6 t·ha−1 között változott.

2. A N-túlsúly, azaz az agronómiailag indokoltat jelentősen meghaladó N-adagok hatására a 4–6 leveles korú növény gyökerének N%-a, a virágzáselejei leve-lek N- és Zn-felvétele, valamint az aratáskori szár N-, K- és Ca-koncentrációja nőtt. A Cu-trágyázással a kontrollhoz viszonyítva a fiatal hajtás, a virágzás elejei levél és a szár Cu-tartalma átlagosan 1/3-ával emelkedett. A gyökér Cu-készlete a Cu-adagolással 2,5-szeresére nőtt. A Cu növényen belüli vertikális mozgása azonban gátolt volt.

3. A 12 t·ha−1 (szem + szár) földfeletti biomasszába kereken 114 kg N, 77 kg K (92 kg K2O), 22 kg P (50 kg P2O5),15 kg Ca, és 18 kg Mg épült be. Az 1 t szem + a hozzátartozó melléktermék fajlagos elemtartalma 15 kg N, 10 kg K (12 kg K2O), 3 kg P (7 kg P2O5), illetve 3 kg körüli CaO és MgO mennyiségnek adódott.

Adataink a tervezett kukoricatermés elemszükségletének számításakor a szakta-nácsadásban használhatók fel.
Cianobaktériumok és eukarióta algák talajszuszpenzióból történő közvetlen vizsgálatának lehetősége áramlási citométerrel
Authors: Lepossa Anita , Hoffmann Sándor , Nagy Szabolcs 
Published: June 2015

A talajokban élő cianobaktériumok és eukarióta algák edafonban betöltött szerepe kulcsfontosságú. Eddig megismert kölcsönhatásaik a talaj más szervezeteivel és a magasabb rendű növényekkel, valamint hozzájárulásuk a talajok mikroszerkezetének kialakulásához és a nitrogénellátáshoz a legismertebbek.
A talajalgák mennyiségi és minőségi kimutatására meglehetősen kevés közvetlen és közvetett sejtszámolási módszer és adat áll rendelkezésre.
Jelen munkánkban Ramannféle barna erdőtalajon őszi búza, bíborhere, kukori-ca és szója parcellákból gyűjtött talajminták cianobaktérium és eukarióta mikroalga sejtszám vizsgálatát végeztük el egy — ezen a téren még újnak számító — nagysebes-ségű, automatizált sejtanalitikai módszer, az áramlási citometria alkalmazásával.
A négy növénykultúrából 2013 júliusában, Keszthelyen, a felszíni öt centiméte-res talajrétegből hat ismétlésben vett talajmintákból vizes szuszpenziót készítettünk, majd mértük azok aktív algasejt-tartalmát. A cianobaktériumokat és az eukarióta algákat klorofill-a és fikoeritrin autofluoreszcencia alapján különböztettük meg a szuszpenzió egyéb elemeitől. A mérésekhez Beckman Coulter FC–500 áramlási citométert használtunk, mintánként öt perc futtatási idővel. A műszer által rögzített eseményszámból következtettünk az algasejtszám-értékekre.
A citométeres ábrákon — megfelelő beállítások után — jól elkülönülő alga sejtpopulációk jelentek meg. Valamennyi mintában a cianobaktériumok domináltak, legalább 60%-os aránnyal. A kukorica talajában mutattuk ki a legnagyobb alga jelenlétet (2,4·105 sejt·g−1 száraz talaj), míg a búzáéban a legkevesebbet, alig 50%-ot (1,1·105 sejt·g−1 száraz talaj). A cianobaktériumok becsült sejtszámát tekintve a kukorica és a szója talajában jelentősen nagyobb abundancia mutatkozott a bíborhere és őszi búza talajához viszonyítva. Szignifikáns különbséget találtunk a becsült eukarióta alga sejtszámban a kukorica- és szója talaja között, a kukorica javára.
Eredményeink igazolták, hogy az áramlási citometria megfelelő és hiánypótló módszer lehet a talajok kvantitatív mikrobiológiai vizsgálatai során, különös tekin-tettel a fotoszintetizáló szervezetekre.