bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole-Genome Sequences of Low-Virulence Strain CB3 and Mild Strain CB7 of Chlamydia psittaci
Authors: Chu Jun , Sun Ruixue , Wu Zongxue , Liu Shanshan , Li Dongfang , Zhang Qiang , Ling Yong , Gong Yanping , Wu Renhua , Wu Honglong , Zhou Jizhang , He Cheng , Ni Peixiang 
Published: June 2014

ABSTRACT

Avian
Chlamydia psittaci
is an obligate intracellular zoonotic pathogen especially dispersed from birds, and it is known to cause pericarditis, pneumonia, lateral nasal adenitis, peritonitis, hepatitis, splenitis, and other diseases. Generalized infections result in fever, anorexia, lethargy, and diarrhea, depending on the chlamydial genotype and the affected bird species. Although many complete genomes of
C. psittaci
have been sequenced, we report here the genomes of two strains isolated from the free-living sparrows (strain CB3) and vinous-throated parrotbill (strain CB7) in China, which were first isolated from the spleens of healthy birds in a routine investigation.
Genome Sequences of Two Leuconostoc pseudomesenteroides Strains Isolated from Danish Dairy Starter Cultures
Authors: Pedersen T. B. , Kot W. P. , Hansen L. H. , Sørensen S. J. , Broadbent J. R. , Vogensen F. K. , Ardö Y. 
Published: June 2014

ABSTRACT

The lactic acid bacterium
Leuconostoc pseudomesenteroides
can be found in mesophilic cheese starters, where it produces aromatic compounds from, e.g., citrate. Here, we present the draft genome sequences of two
L. pseudomesenteroides
strains isolated from traditional Danish cheese starters.
Genome Sequence of a Promising Hydrogen-Producing Facultative Anaerobic Bacterium, Brevundimonas naejangsanensis Strain B1
Authors: Su Haijia , Zhang Ting , Bao Meidan , Jiang Yixin , Wang Yu , Tan Tianwei 
Published: June 2014

ABSTRACT

Brevundimonas naejangsanensis
strain B1 is a newly isolated, facultative anaerobic bacterium capable of producing hydrogen with high efficiency. Here, we present a 2.94-Mb assembly of the genome sequence of strain B1, which may provide further insights into the molecular mechanism of hydrogen production from bioresource.
Draft Genome Sequences of
Geobacillus
sp. Strains CAMR5420 and CAMR12739
Authors: De Maayer Pieter , Williamson Carolyn E. , Vennard Christopher T. , Danson Michael J. , Cowan Don A. 
Published: June 2014

ABSTRACT

Thermophilic
Geobacillus
spp. can efficiently hydrolyze hemicellulose polymers and are therefore of interest in biotechnological applications. Here we report the genome sequences of two hemicellulolytic strains,
Geobacillus
sp. CAMR12739 and CAMR5420.
Progressive intracranial hypertension and cerebral hypoperfusion in a fatal case of cerebral aspergilloma
Authors: Toksvang Linea Natalie , Plovsing Ronni R , Berg Ronan M G 
Published: June 2014

SummaryWe report a case of cerebral aspergilloma in a 25-year-old immunoincompetent man admitted to a general intensive care unit. Monitoring of intracranial pressure was instigated and revealed hour-long epochs of severe intracranial hypertension, despite a normal opening pressure, with decreases in cerebral perfusion pressure. We documented that this was associated with cerebral hypoperfusion by transcranial Doppler ultrasound. The present case illustrates that severe intracranial hypertension may evolve despite a normal opening pressure; it furthermore shows that continuous monitoring of intracranial pressure may be used to predict changes in cerebral haemodynamics in critically ill patients with neuroinfection.
Comparison of the aetiology of stillbirth over five decades in a single centre: a retrospective study
Authors: Wou Karen , Ouellet Marie-Pier , Chen Moy-Fong , Brown Richard N 
Published: June 2014

ObjectiveTo compare the rates and aetiologies of stillbirth over the past 50 years.Study designWe reviewed all autopsy reports for stillbirths occurring between 1989 and 2009 at the McGill University Health Centre to determine the pathological aetiology of stillbirths. We also reviewed maternal characteristics. We compared our results with a previous study published in 1992 on aetiologies of stillbirth from 1961 to 1988 at the same institution.ResultsFrom among the 79 410 births between 1989 and 2009, 217 stillbirths were included in our study. The mean maternal age was 31.05 (±5.8) years. In 28.1% of cases, there was a history of subfertility. The mean gestational age at diagnosis was 32.69 (±5.58) weeks, with a birthweight of 1888 (±1084) g. The main causes of stillbirth were unknown (26.7%), placental factors (19.8%) and abruptio placentae (12.9%). Other causes included haematogenous or ascending infection (10.6%), fetal malformations (8.3%), maternal hypertension (3.2%), intrauterine growth restriction (2.8%), diabetes (1.8%) and intrapartum asphyxia (1.4%). Other fetal causes were found in 12.4% of cases.ConclusionsOwing to detailed pathological examination of most stillbirth cases over the past five decades at our tertiary obstetrical centre, we could study the trends in the aetiology of stillbirths in a cohort of more than 150 000 births. In 50 years, the rate of stillbirth has decreased from 115 to 32 cases/10 000 births from the 1960s to 2000s, which represents a reduction of 72%. Stillbirth from unknown cause remains the most common contributor, with 40% of these cases occurring in late pregnancy.
Predictors of injury mortality: findings from a large national cohort in Thailand
Authors: Yiengprugsawan Vasoontara , Berecki-Gisolf Janneke , Bain Christopher , McClure Roderick , Seubsman Sam-ang , Sleigh Adrian C 
Published: June 2014

ObjectiveTo present predictors of injury mortality by types of injury and by pre-existing attributes or other individual exposures identified at baseline.Design5-year prospective longitudinal study.SettingContemporary Thailand (2005–2010), a country undergoing epidemiological transition.ParticipantsData derived from a research cohort of 87 037 distance-learning students enrolled at Sukhothai Thammathirat Open University residing nationwide.MeasuresCohort members completed a comprehensive baseline mail-out questionnaire in 2005 reporting geodemographic, behavioural, health and injury data. These responses were matched with national death records using the Thai Citizen ID number. Age–sex adjusted multinomial logistic regression was used to calculate ORs linking exposure variables collected at baseline to injury deaths over the next 5 years.ResultsStatistically significant predictors of injury mortality were being male (adjustedOR 3.87, 95% CI 2.39 to 6.26), residing in the southern areas (AOR 1.71, 95% CI 1.05 to 2.79), being a current smoker (1.56, 95% CI 1.03 to 2.37), history of drunk driving (AOR 1.49, 95% CI 1.01 to 2.20) and ever having been diagnosed for depression (AOR 1.91, 95% CI 1.00 to 3.69). Other covariates such as being young, having low social support and reporting road injury in the past year at baseline had moderately predictive AORs ranging from 1.4 to 1.6 but were not statistically significant.ConclusionsWe complemented national death registration with longitudinal data on individual, social and health attributes. This information is invaluable in yielding insight into certain risk traits such as being a young male, history of drunk driving and history of depression. Such information could be used to inform injury prevention policies and strategies.
Identification of the optimum vagal manoeuvre technique for maximising vagal tone
Authors: Smith Gavin , Broek Alicia , Taylor David McD , Morgans Amee , Cameron Peter 
Published: June 2014

ObjectivesThis study sought to determine the most effective technique for Valsalva Manoeuvre (VM) and Human Dive Reflex Manoeuvre (HDR) generation of vagal tone.MethodsWe conducted a repeated-measures trial of healthy adult volunteers from a university campus, aged 18–56 years, in sinus rhythm. Participants were randomised to VM (in supine or Trendelenberg postures) and HDR (supine or sitting postures) sequentially. Participants performed three trials of each technique, in random order, with a continuous ECG recording. Single-blinded analysis of ECG data was conducted. Mean differences between premanoeuvre and postmanoeuvre R-R intervals and heart rates were calculated for each posture within and between vagal manoeuvres.ResultsSeventy-two participants were enrolled. The difference between VM (supine) and VM (Trendelenberg) was not significant at 0.008 s (−0.023 to 0.038). The difference in mean R-R intervals for HDR (supine) was greater than HDR (sitting) 0.062 (0.031 to 0.093), although this significance was not reflected in a heart-rate change of −0.87 (−3.00 to 1.26). VM supine generated greatest overall mean R-R interval difference, while HDR (sitting) provided the smallest change in R-R interval. The VM (supine) provided a significant maximum effectiveness over the HDR (supine) of 0.102 s (0.071 to 0.132).ConclusionsThis study demonstrates that VM (supine) generates the greatest vagal tone producing the largest transient heart rate decrease in healthy volunteers. No advantage was identified in Trendelenberg posturing for the VM in this study. These results may assist in the standardisation of vagal manoeuvre technique for the range of therapeutic and diagnostic applications.
A Conversation with Irma Adelman
Authors: Adelman Irma , Zilberman David , Kim Eunice 
Published: June 2014

Irma Adelman was born in Czernowitz, Romania, in March of 1930. Her father was a Jewish businessman with socialist leanings, and although her mother was educated to be a lawyer, she never practiced and thus concentrated her energies on her only daughter, Irma. Despite Irma’s Jewish background, she was educated by French Catholic nuns, and her family lived in affluence in her early life. It was not long before her family encountered anti-Semitism and discrimination in the late 1930s, her father foresaw the dark shadow of World War II, and the family immigrated to Palestine in 1939. Irma attended high school in Palestine and also fought in the Israeli war of independence. After the war, she immigrated to the United States, where she enrolled as an undergraduate at the University of California, Berkeley (UC Berkeley), as a business administration major. Soon after her arrival at Berkeley, she met and married her husband, an American physics PhD candidate. They decided to settle in the United States and had one son, Alex. After her undergraduate studies, Irma enrolled at UC Berkeley as a PhD student in economics. Given her strong quantitative skills, she benefited from training by Robert Dorfman in mathematical models in economics and from courses in econometrics and statistics offered by George Kuznets in the Department of Agricultural Economics. Her classmates in Kuznets's courses included Arnold Zellner, Zvi Griliches, and Yair Mundlak. After graduating at the top of her class in 1955, Irma faced considerable difficulties in landing a tenure-track academic position, which was typical of the discrimination against professional women at the time. She held various nontenure appointments at UC Berkeley, at Mills College, and at Stanford for several years. During this period, she published her first book ( Adelman & Morris 1973 ), the classic Klein-Goldberger paper ( Adelman & Adelman 1959 ), and the pathbreaking hedonic pricing paper ( Adelman & Griliches 1961 ), as well as many other publications in leading journals. Yet she was still unable to land a tenure-track position in the Bay Area. She and her husband decided to relocate due to her husband’s job offer, and thus she moved to Washington, DC, where she obtained a regular associate professorship at John Hopkins University. There she also met Cynthia Taft Morris, who would later become a lifelong friend and collaborator. While in Washington, DC, she became acquainted with agencies such as USAID and the World Bank. In 1966, she moved to Chicago for a position at Northwestern University, where she stayed until 1971. In 1973, she joined the World Bank along with having a professorship at the University of Maryland. From Maryland, in 1979 she returned to UC Berkeley’s Department of Agricultural Economics, where she stayed until her early retirement in 1995. She has been a professor emeritus of the Graduate School ever since.
Fine-Mapping IGF1 and Prostate Cancer Risk in African Americans: The Multiethnic Cohort Study
Authors: Giorgi Elena E. , Stram Daniel O. , Taverna Darin , Turner Stephen D. , Schumacher Fredrick , Haiman Christopher A. , Lum-Jones Annette , Tirikainen Maarit , Caberto Christian , Duggan David , Henderson Brian E. , Le Marchand Loic , Cheng Iona 
Published: June 2014

Abstract
Genetic variation at insulin-like growth factor 1 (IGF1) has been linked to prostate cancer risk. However, the specific predisposing variants have not been identified. In this study, we fine-mapped the IGF1 locus for prostate cancer risk in African Americans. We conducted targeted Roche GS-Junior 454 resequencing of a 156-kb region of IGF1 in 80 African American aggressive prostate cancer cases. Three hundred and thirty-four IGF1 SNPs were examined for their association with prostate cancer risk in 1,000 African American prostate cancer cases and 991 controls. The top associated SNP in African Americans, rs148371593, was examined in an additional 3,465 prostate cancer cases and 3,425 controls of non-African American ancestry—European Americans, Japanese Americans, Latinos, and Native Hawaiians. The overall association of 334 IGF1 SNPs and prostate cancer risk was assessed using logistic kernel-machine methods. The association between each SNP and prostate cancer risk was evaluated through unconditional logistic regression. A false discovery rate threshold of q &lt; 0.1 was used to determine statistical significance of associations. We identified 8 novel IGF1 SNPs. The cumulative effect of the 334 IGF1 SNPs was not associated with prostate cancer risk (P = 0.13) in African Americans. Twenty SNPs were nominally associated with prostate cancer at P &lt; 0.05. The top associated SNP among African Americans, rs148371593 [minor allele frequency (MAF) = 0.03; P = 0.0014; q &gt; 0.1], did not reach our criterion of statistical significance. This polymorphism was rare in non-African Americans (MAF &lt; 0.003) and was not associated with prostate cancer risk (P = 0.98). Our findings do not support the role of IGF1 variants and prostate cancer risk among African Americans. Cancer Epidemiol Biomarkers Prev; 23(9); 1928–32. ©2014 AACR.
LOBULITE LINFOCITÁRIA ESCLEROSANTE EM PACIENTES COM DIABETES MELLITUS TIPO 1
Authors: Ribeiro-Silva Alfredo 
Published: June 2014

Modelo do estudo: Revisão da literatura. Importância do problema: A mastopatia diabética é uma doença mamária benigna freqüentemente associada ao diabetes melitus do tipo 1 de longa evolução. Comentários: Embora consagrado pelo uso, o termo mastopatia diabética não é correto porque um quadro morfológico idêntico (lobulite linfocítica esclerosante) pode aparecer em mulheres com outras doenças autoimunes e mesmo em mulheres sem nenhuma alteração sistêmica aparente.
ATIVIDADE OCUPACIONAL E CATARATA SENIL – OPINIÃO DE PACIENTES DE HOSPITAL UNIVERSITÁRIO
Authors: Marback Roberta F. , Temporini Edméa R. , Maia Junior Otacílio O. , Schaefer Tânia , Kara-José Junior Newton , Kara-José Newton 
Published: June 2014

Objetivo: Identificar a situação ocupacional e percepções de portadores de catarata senil sobre a relação entre a atividade ocupacional exercida e o surgimento da doença. Métodos: Desenvolveu-se estudo observacional transversal descritivo, por meio de questionário estruturado, aplicado por entrevista, elaborado a partir de estudo exploratório. A amostra, prontamente acessível, foi formada por pacientes atendidos pelo setor de catarata da clínica oftalmológica de um hospital universitário. Resultados: A amostra foi constituída por 110 sujeitos de ambos os sexos (34,5% homens; 65,5% mulheres), com idade entre 43 e 89 anos, ± 10,3 anos. A maior proporção dos entrevistados não exercia atividade remunerada (87,3%). Dentre as opiniões acerca das causas da catarata, destacaram-se a velhice (69,1%), o uso excessivo dos olhos (57,3%) e a exposição ao calor nos olhos (40,9%). Quanto à opinião sobre relação entre atividades profissionais exercidas e catarata, 56,4% não acreditavam que o trabalho tivesse influído, enquanto 43,6% atribuíram às atividades ocupacionais a essa afecção ocular. Foram atribuídos às atividades profissionais: o cansaço visual (37,5%), contato com calor excessivo (12,5%) e uso de produto químico (10,3%). Conclusões: Evidenciou-se predominância acentuada de idosos de baixa escolaridade, não mais exercendo atividade ocupacional e inativos no mercado de trabalho. Entre os que exerciam, prevaleceram as ocupações manuais especializadas, o que sugere reduzido nível socioeconômico e baixo poder aquisitivo. Atribuíram como causas do comprometimento visual situações decorrentes de atividades ocupacionais, como o uso excessivo dos olhos e a exposição ao calor, evidenciando-se conhecimentos errôneos.
RATOS ESPONTANEAMENTE HIPERTENSOS E NEUROPATIAS PERIFÉRICAS
Authors: Fazan Valéria P. S. , Kalil Andréa L. R. , Alcântara Adriana C. L. , Genari Adriana B. , Tavares Marcelo R. , Rodrigues Anaceres R. , Salgado Helio C. 
Published: June 2014

Modelo do Estudo: O presente estudo é uma revisão de literatura sobre o modelo de hipertensão espontânea e as conseqüências da hipertensão para o sistema nervoso periférico, somático e autonômico. Importância do problema: Hipertensão é o principal fator de risco para acidente vascular cerebral e demência vascular, por causar importantes mudanças cerebrovasculares, tornando o cérebro propenso a infartos, microaneurismas e isquemias. As principais mudanças causadas no sistema nervoso central (SNC) pela hipertensão, incluem: diminuição do volume cerebral, aumento no volume dos ventrículos e perda neuronal. Além das alterações no cérebro, a hipertens ão causa outros danos que culminam em uma série de alterações patológicas renais e outras doenças, as quais sustentam a elevação da pressão arterial, aumento da freqüência cardíaca, e aumento da resistência vascular periférica. O rato espontaneamente hipertenso (SHR) é reconhecido como um excelente modelo de hipertensão experimental e pode servir como modelo de estudos clínicos da hipertensão essencial humana. Embora esse modelo tenha sido bastante explorado em termos fisiológicos, estudos morfológicos, quando presentes, se limitam aos vasos. Mesmo quando nervos periféricos foram estudados morfologicamente nesses animais, os vasos epineurais, perineurais e endoneurais foram o alvo do estudo. Raros são os estudos que envolvem as fibras nervosas nesse modelo de hipertensão. Comentários: Recentemente, estudamos as alterações do nervo depressor aórtico (NDA) em SHR. Nossos resultados mostraram redução do tamanho das fibras mielínicas e redução do tamanho e número das fibras amielínicas, comparados aos controles normotensos da linhagem Wistar-Kyoto. Outro estudo recente do nosso laboratório mostrou que, embora os níveis pressóricos dos SHR machos, bem como a freqüência cardíaca, sejam muito superiores aos das fêmeas, não há diferença morfológica nos nervos vagos cervicais entre SHR machos e fêmeas. Ainda, fazemos uma descrição morfológica e morfométrica do nervo sural de SHR, fornecendo parâmetros morfológicos para posteriores estudos funcionais.
REPRESENTAÇÕES SOCIAIS DA SURDEZ
Authors: Bittencourt Zélia Z L C , Montagnoli Ana Paula 
Published: June 2014

O objetivo deste estudo foi conhecer as representações sociais e o impacto da surdez no cotidiano de familiares de crianças surdas. Métodos: Nesta investigação adotou-se a metodologia qualitativa utilizando-se entrevistas com questões abertas como ferramenta de coleta de dados. A amostra contou com 15 familiares (pais ou mães) de crianças surdas atendidas em um serviço de reabilitação. Resultados : A surdez foi representada como “um fardo”, “sofrimento”, “transtorno”, “sobrecarga” gerando “sentimento de culpa”, e dificuldade de aceitação por parte da família, enquanto a reabilitação remete à idéias de “socialização”, “respeito’ e “aceitação” no meio social. Conclusão : O conhecimento das representações e expectativas dos pais trouxe subsídios para novas ações que incluam maior atenção às famílias, incentivo à participação em grupos de pais, visando a troca de experiências.
ESTADIAMENTO DO CÂNCER DE MAMA DIAGNOSTICADO NO SISTEMA PÚBLICO DE SAÚDE DE SÃO CARLOS
Authors: Macchetti Alexandre Henrique 
Published: June 2014

Introdução: dados sobre o estadio do câncer no momento do diagnóstico são facilmente disponíveis para a maioria dos países desenvolvidos, mas para os países da América Latina estes são difíceis de serem obtidos. Dados do Instituto Nacional do Câncer referem 60% dos casos de câncer de mama em estadio avançado, no entanto o presente do Serviço de Mastologia da Secretaria de Saúde de São Carlos mostrou dados diversos que estimularam a avaliação da idade e do estadio do câncer de mama dos pacientes do Sistema Único de Saúde residentes na cidade de São Carlos e a comparação às estatísticas de outras instituições. Pacientes e Métodos: registros de 106 pacientes com diagnóstico de câncer de mama entre Março de 2000 e Dezembro de 2004 no Serviço de Mastologia da Secretaria de Saúde de São Carlos (SUS) foram revisados quanto ao estadio e a idade no momento do diagnóstico. Os casos de câncer de mama foram agrupados segundo os sistemas de estadiamento TNM e SEER, e a idade conforme valor acima ou abaixo da idade mediana do grupo de pacientes com o objetivo de correlacioná-los. Resultados: no sistema de estadiamento TNM os tumores corresponderam a 6,6% de todos os casos, tumores no estadio I a 25,4%, estadio II a 44,3%, estadio III a 17,0 % e estadio IV a 6,6%. No sistema de estadiamento SEER os tumores in situ corresponderam a 6,6% de todos os casos, tumores locais a 62,2%, tumores regionais a 24,5%, e disseminados a 6,6%. Houve mais casos em estadio inicial utilizando o sistema TNM (76,3%) do que o sistema SEER (68,8%). Houve associação do grupo de pacientes com menos de 56 anos com o estadio inicial ao diagnóstico com o sistema TNM, mas não com o sistema SEER. Conclusões: dados relevantes para o melhor entendimento da atenção ao câncer de mama são apresentados, permitindo melhora das intervenções ao nível da comunidade para detecção do câncer e também uma estratégia dirigida por dados na alocação de recursos para políticas, programas e serviços relacionados ao câncer.