bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melanoma of the gallbladder: appropriate surgical management and review of the literature
Authors: Christou Demetris , Katodritis Nicos , Decatris Marios P. , Katodritou Angela , Michaelides Ioannis , Nicolaou Nicolaos , Kounoushis Michalis , Hadjicostas Panayiotis 
Published: September 2014

Key Clinical MessageMelanomas of the gallbladder (GB) are extremely rare with a very poor prognosis. They feature in the literature as a few case reports and the method of their management is not clear. We report a case of patient with metastatic cutaneous melanoma to the GB, and our treatment suggestion.
Kinetic Monte Carlo Simulations and Molecular Conductance Measurements of the Bacterial Decaheme Cytochrome MtrF
Authors: Byun Hye Suk , Pirbadian Sahand , Nakano Aiichiro , Shi Liang , El‐Naggar Mohamed Y. 
Published: September 2014

AbstractMicroorganisms overcome the considerable hurdle of respiring extracellular solid substrates by deploying large multiheme cytochrome complexes that form 20 nanometer conduits to traffic electrons through the periplasm and across the cellular outer membrane. Here we report the first kinetic Monte Carlo simulations and single‐molecule scanning tunneling microscopy (STM) measurements of the Shewanella oneidensis MR‐1 outer membrane decaheme cytochrome MtrF, which can perform the final electron transfer step from cells to minerals and microbial fuel cell anodes. We find that the calculated electron transport rate through MtrF is consistent with previously reported in vitro measurements of the Shewanella Mtr complex, as well as in vivo respiration rates on electrode surfaces assuming a reasonable (experimentally verified) coverage of cytochromes on the cell surface. The simulations also reveal a rich phase diagram in the overall electron occupation density of the hemes as a function of electron injection and ejection rates. Single‐molecule tunneling spectroscopy confirms MtrF’s ability to mediate electron transport between an STM tip and an underlying Au(111) surface, but at rates higher than expected from previously calculated heme‐to‐heme electron transfer rates for solvated molecules.
Unexpected Cyclization of Tritylamines Promoted by Copper Salt through CH and CN Bond Cleavages to Produce Acridine Derivatives
Authors: Morioka Ryosuke , Hirano Koji , Satoh Tetsuya , Miura Masahiro 
Published: September 2014

AbstractHerein, we demonstrate that tritylamines undergo an unprecedented copper‐mediated cyclization involving the cleavages of two CH bonds and one CN bond to give 9‐arylacridine derivatives. This kind of acridines is of interest due to their biological properties and their unique optical and electro‐ and photochemical properties. Some of obtained acridine derivatives exhibit intense fluorescence in the solid state.
SEAL by NMR: Glyco‐Based Selenium‐Labeled Affinity Ligands Detected by NMR Spectroscopy
Authors: Hamark Christoffer , Landström Jens , Widmalm Göran 
Published: September 2014

AbstractWe report a method for the screening of interactions between proteins and selenium‐labeled carbohydrate ligands. SEAL by NMR is demonstrated with selenoglycosides binding to lectins where the selenium nucleus serves as an NMR‐active handle and reports on binding through 77Se NMR spectroscopy. In terms of overall sensitivity, this nucleus is comparable to 13C NMR, while the NMR spectral width is ten times larger, yielding little overlap in 77Se NMR spectroscopy, even for similar compounds. The studied ligands are singly selenated bioisosteres of methyl glycosides for which straightforward preparation methods are at hand and libraries can readily be generated. The strength of the approach lies in its simplicity, sensitivity to binding events, the tolerance to additives and the possibility of having several ligands in the assay. This study extends the increasing potential of selenium in structure biology and medicinal chemistry. We anticipate that SEAL by NMR will be a beneficial tool for the development of selenium‐based bioactive compounds, such as glycomimetic drug candidates.
ChemInform Abstract: B182‐: A Quasi‐Planar Bowl Member of the Wankel Motor Family.
Authors: Moreno Diego , Pan Sudip , Zeonjuk Lei Liu , Islas Rafael , Osorio Edison , Martinez‐Guajardo Gerardo , Chattaraj Pratim K. , Heine Thomas , Merino Gabriel 
Published: September 2014

AbstractBowl‐like structured B182‐ as the fifth member of the so‐called “Wankel motor” family is found.
ChemInform Abstract: Na1.67Mn2.17(MoO4)3.
Authors: Bouzidi Chahira , Zid Mohamed Faouzi , Driss Ahmed , Frigui Wafa 
Published: September 2014

AbstractThe title compound is prepared by solid state reaction of Na2CO3, Mn(OAc)3·2H2O, and (NH4)2Mo4O13 in the molar ratio Na:Mn:Mo = 2:2:3 (porcelain crucible, 998 K, 3 weeks).
ChemInform Abstract: β‐Nb9VO25.
Authors: Nasri Rawia , Cherif Saida Fatma , Zid Mohamed Faouzi , Driss Ahmed 
Published: September 2014

Abstractβ‐Nb9VO25 is prepared by a solid‐state reaction of Nb2O5, V2O5, and Na2CO3 in the molar ratio of Na:Nb:V = 3:6:1 (porcelain crucible, 1198 K, 1 week, slow cooling).
ChemInform Abstract: Crystal Structure of Ammonium Divanadium(IV,V) Tellurium(IV) Heptaoxide.
Authors: Harrison William T. A. , Johnston Magnus G. 
Published: September 2014

Abstract(NH4)(VIVO2)(VVO2) (TeO3) is obtained by solvothermal processing of a mixture of V2O5, TeO2, NH3, and H2O (pH 8.5, autoclave, 438 K, 3 d).
ChemInform Abstract: Tetraammineplatinum(II) Dichloride Ammonia Tetrasolvate.
Authors: Grassl Tobias , Korber Nikolaus 
Published: September 2014

AbstractSingle crystals of [Pt(NH3)4]Cl2·4NH3 are grown from a mixture of PtCl2 and N‐acetylglucosamine in liquid NH3 (1.
ChemInform Abstract: Hydrated Manganese(II) Phosphate (Mn3(PO4)2·3H2O) as a Water Oxidation Catalyst.
Authors: Nam Ki Tae , et al. et al. 
Published: September 2014

AbstractMn3(PO4)2·3H2O is precipitated from an equimolar solution of KH2PO4 in HEPES (4‐(2‐hydroxyethyl)‐1‐piperazineethanesulfonic acid) buffer and aqueous MnCl2 (pH 7.4, 37 °C, 3 h).
ChemInform Abstract: A Facile Synthesis and Characterization of Sodium Bismuth Sulfide (NaBiS2) under Hydrothermal Condition.
Authors: Kang Sumin , Hong Yonghoon , Jeon Youngjin 
Published: September 2014

AbstractNanosheets of the title compound are hydrothermally synthesized as the sole product from mixtures of Bi(NO3)3, L‐cysteine, NaOH, and H2O (autoclave, 180 °C, 72 h, 46% yield).
ChemInform Abstract: Magnetically Retrievable Nano Crystalline Nickel Ferrite‐Catalyzed Aerobic, Ligand‐Free C—N, C—O and C—C Cross‐ Coupling Reactions for the Synthesis of a Diversified Library of Heterocyclic Molecules.
Authors: Paul Sanjay , Pradhan Koyel , Ghosh Sirshendu , De S. K. , Das Asish R. 
Published: September 2014

AbstractA facile protocol using NiFe2O4 nanoparticles as catalyst allows for the effective N‐arylation of amines, O‐arylation of phenols or hydroxycoumarins, and biaryl/heteroaryl synthesis.
ChemInform Abstract: Palladium Catalyzed N—H Bond Insertion and Intramolecular Cyclization Cascade: The Divergent Synthesis of Heterocyclics.
Authors: Ding Dong , Liu Gang , Xu Guangyang , Li Jian , Wang Guoping , Sun Jiangtao 
Published: September 2014

AbstractThe Pd‐catalyzed N—H insertion reaction of vinyldiazoacetates (II) with o‐triflate‐anilines (I) followed by a base‐promoted cyclization leads to lactones (III).
ChemInform Abstract: Palladium‐Catalyzed Annulation of Internal Alkynes in Aqueous Medium.
Authors: Ang Wei Jie , Tai Chih‐Hsuan , Lo Lee‐Chiang , Lam Yulin 
Published: September 2014

AbstractIt is demonstrated, that a reusable palladacycle efficiently catalyzes the carbo‐ and heteroannulation of internal alkynes with a wide variety of functionalized aryl halides in aqueous media.
ChemInform Abstract: Microwave‐Assisted Synthesis of Quinoxaline Derivatives Using Glycerol as a Green Solvent.
Authors: Zhou W.‐J. , Zhang X.‐Zh. , Sun X.‐B. , Wang B. , Wang J.‐X. , Bai L. 
Published: September 2014

AbstractThe microwave‐assisted synthesis of quinoxaline derivatives using glycerol as solvent is described.
ChemInform Abstract: Reductive Amination of Aldehydes and Amines with an Efficient Pd/NiO Catalyst.
Authors: Yang Huimin , Cui Xinjiang , Deng Youquan , Shi Feng 
Published: September 2014

AbstractThe Pd/NiO catalyst exhibits excellent activity and selectivity in the reductive amination reaction using a wide range of amines and aldehydes as substrates.
ChemInform Abstract: Regio‐ and Diastereoselective Construction of α‐Hydroxy‐δ‐amino Ester Derivatives via 1,4‐Conjugate Addition of β,γ‐Unsaturated N‐Sulfonylimines.
Authors: Qiu Lin , Gao Lixin , Tang Jixing , Wang Dongwei , Guo Xin , Liu Shunying , Yang Liping , Li Jia , Hu Wenhao 
Published: September 2014

AbstractThe title compounds show inhibitory activity on PTP1B and SIRT1 enzymes in vitro.
ChemInform Abstract: Cu(II)‐Mediated C—H Amidation and Amination of Arenes: Exceptional Compatibility with Heterocycles.
Authors: Shang Ming , Sun Shang‐Zheng , Dai Hui‐Xiong , Yu Jin‐Quan 
Published: September 2014

AbstractThe new method for the C—H amidation and amination of (hetero)arenes employs a readily removable directing group.
ChemInform Abstract: One‐Pot Synthesis of Mannich Bases under Solvent‐Free Conditions.
Authors: Demirkol Onur , Akbaslar Dilek , Giray Sultan , Anil B. Baris 
Published: September 2014

AbstractThe reported protocol offers several advantages such as good yield, simple processing with easy work‐up and without use of any volatile, hazardous organic solvents and metallic catalysts.
ChemInform Abstract: Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines Using a Recyclable Palladium Nanoparticle Catalyst Together with Lipases.
Authors: Gustafson Karl P. J. , Lihammar Richard , Verho Oscar , Engstroem Karin , Baeckvall Jan‐E. 
Published: September 2014

AbstractIn the presence of lipase B from Candida antarctica and Pd‐nanoparticles immobilized on amino‐functionalized siliceous mesocellular foam, primary benzylic amines are found to undergo efficient dynamic kinetic resolution.
ChemInform Abstract: Reaction of Phenols with 1‐Adamantanol in the Presence of 1‐Bromoadamantane.
Authors: Sokolenko W. A. , Svirskaya N. M. , Rubaylo A. I. 
Published: September 2014

AbstractThe adamantylation of phenols with 1‐adamantanol in the presence of 1‐bromoadamantan is described.
ChemInform Abstract: Iron‐Catalyzed Cross‐Dehydrogenative Coupling Esterification of Unactive C(sp3)—H Bonds with Carboxylic Acids for the Synthesis of α‐Acyloxy Ethers.
Authors: Zhao Jincan , Fang Hong , Zhou Wei , Han Jianlin , Pan Yi 
Published: September 2014

AbstractIntermolecular competing kinetic isotope effect experiments indicate, that C(sp3)—H bond cleavage may be the rate‐determining step of this cross dehydrogenative coupling reaction.
ChemInform Abstract: Synthesis of Thio‐heterocyclic Analogues from Baylis—Hillman Bromides as Potent Cyclooxygenase‐2 Inhibitors.
Authors: Santhoshi Amlipur , Mahendar Budde , Mattapally Saidulu , Sadhu Partha Sarathi , Banerjee Sanjay Kumar , Jayathirtha Rao Vaidya 
Published: September 2014

Abstract20 Compounds of type (VI) are prepared and screened for their COX‐1 and COX‐2 inhibitory activities.
ChemInform Abstract: Silica‐acac‐Supported Palladium Nanoparticles as an Efficient and Reusable Heterogeneous Catalyst in the Suzuki—Miyaura Cross‐Coupling Reaction in Water.
Authors: Hajipour Abdol Reza , Shirdashtzade Zohre , Azizi Ghobad 
Published: September 2014

AbstractThe catalyst can be reused up to six times without significant loss of its catalytic activity.
ChemInform Abstract: The Practical Preparation of Chiral N‐Sulfonyl Oxaziridines via Catalytic Asymmetric Payne Oxidation.
Authors: Tsutsumi Ryosuke , Kim Seonwoo , Uraguchi Daisuke , Ooi Takashi 
Published: September 2014

AbstractAromatic and aliphatic N‐sulfonyl imines are converted to N‐sulfonyl oxaziridines with excellent enantioselectivities.
ChemInform Abstract: A Facile and General Route to 3‐((Trifluoromethyl)thio)benzofurans and 3‐((Trifluoromethyl)thio)benzothiophenes
Authors: Sheng Jie , Fan Congbin , Wu Jie 
Published: September 2014

Abstractvia BiCl3‐promoted reaction of trifluoromethanesulfanylamide with 1‐methoxy‐2‐alkynylbenzenes (I) or related sulfanes (IV)
ChemInform Abstract: Concise Synthesis of 6‐Cyanobenzo[b]furan, a Useful Building Block.
Authors: Nguyen Son T. , Williams John D. , Majgier‐Baranowska Helena , Li Bing , Neelagiri Venugopal R. , Kim Hwa‐Ok , Peet Norton P. 
Published: September 2014

AbstractThe described synthesis starts from the commercially available furan‐3‐one derivative (I) which undergoes a reductive dehydration and conversion to a triflate derivative.
ChemInform Abstract: Pyrroles versus Cyclic Nitrones: Catalyst‐Controlled Divergent Cyclization of N‐(2‐Perfluoroalkyl‐3‐alkynyl) Hydroxylamines.
Authors: Zeng Qin , Zhang Li , Yang Jieru , Xu Bing , Xiao Yuanjing , Zhang Junliang 
Published: September 2014

AbstractNovel divergent cyclizations of perfluoroalkylated and alkynyl‐substituted hydroxylamines are developed.
ChemInform Abstract: Mild Gold‐Catalyzed Three‐Component Dehydrogenative Coupling of Terminal Alkynes to Amines and Indole‐2‐carboxaldehyde
Authors: Li Jian , Wang Hongni , Sun Jiangtao , Yang Yang , Liu Li 
Published: September 2014

Abstractleading to indoles (IV), (VI), and (VIII)
ChemInform Abstract: One‐Pot Conversion of 1‐Bromo‐β‐carboline and 1‐Bromocarbazole into Pentacyclic Compounds by Suzuki Cross‐Coupling Followed by Spontaneous Cyclization.
Authors: Gehring Andre P. , Tremmel Tim , Bracher Franz 
Published: September 2014

AbstractThe regioisomer of (VII), 3‐formylthiophene‐2‐boronic acid, fails to give defined products.
ChemInform Abstract: Silver(I)‐Promoted Intramolecular Addition of N‐Heterocyclic Carbenes Towards Unsaturated Esters in Water
Authors: Shang Xiaobo , Chen Chao , Qiu Huayu , Chen Wanzhi 
Published: September 2014

Abstract[as a facile method for the synthesis of imidazo[1,2‐a]indole derivatives].
ChemInform Abstract: Recoverable Cu/SiO2 Composite‐Catalyzed Click Synthesis of 1,2,3‐Triazoles in Water Media.
Authors: Radatz Catia Schwartz , Soares Liliana do Amaral , Vieira Estefano Roberto , Alves Diego , Russowsky Dennis , Schneider Paulo Henrique 
Published: September 2014

AbstractA green version of Huisgen reaction is developed.
ChemInform Abstract: Synthesis and Anticonvulsant Activity Evaluation of 7‐Alkoxy[1,2,4]triazolo[3,4‐b]benzothiazol‐3(2H)‐ones.
Authors: Liu Da‐Chuan , Deng Xian‐Qing , Wang Shi‐Ben , Quan Zhe‐Shan 
Published: September 2014

AbstractAmong the title compounds (III) (21 examples), derivatives (IIIa) and (IIIb) show the highest anticonvulsant activity.
ChemInform Abstract: A Rapid Approach for the Copper, Amine, and Ligand‐Free Sonogashira Coupling of 4‐Methyl‐7‐nonafluorobutylsulfonyloxy Coumarins under Microwave Irradiation.
Authors: Joy M. Nibin , Bodke Yadav D. , Abdul Khader K. K. , Sajith Ayyiliyath M. 
Published: September 2014

AbstractThe key for success of the coupling of nonaflate (I) with alkynes is the use of hydrated Bu4NF as mild base and as solvating agent to suppress the competitive nonaflate hydrolysis.
ChemInform Abstract: One‐Pot Four‐Component Approach for the Construction of Dihydropyridines and Dihydropyridinones Using Amines and Activated Alkynes.
Authors: Kiruthika Selvarangam E. , Perumal Paramasivan T. 
Published: September 2014

AbstractThis is the first report on the synthesis of dihydropyridines using dimethyl acetylenedicarboxylate, primary amines, and in situ generated Knoevenagel condensation products.
ChemInform Abstract: Rapid and Efficient Synthesis of 1,4‐Dihydropyridines Using a Sulfonic Acid‐Functionalized Ionic Liquid.
Authors: Nia Roghayeh Hossein , Mamaghani Manouchehr , Shirini Farhad , Tabatabaeian Khalil , Heidary Marzieh 
Published: September 2014

AbstractTitle compounds are prepared under neat conditions using a sulfonic acid‐functionalized ionic liquid as catalyst which can be easily recycled and reused several times without significant loss of activity.
ChemInform Abstract: One‐Pot Synthesis of Octahydroqinazolinones Derivatives Catalyzed by [C4(mim)2](FeCl4)2 under Solvent Free Conditions.
Authors: Godajdar Bijan Mombani , Soleimani Soghra 
Published: September 2014

AbstractThe dicationic liquid mentioned in the title is reported to be an efficient catalyst for the three component reaction of cyclohexa‐1,3‐diones (I), aromatic aldehydes (II), and urea or thiourea under solvent free conditions.
ChemInform Abstract: Four‐Component Strategy for Selective Synthesis of Azepino[5,4,3‐cd]indoles and Pyrazolo[3,4‐b]pyridines.
Authors: Jiang Bo , Ye Qin , Fan Wei , Wang Shu‐Liang , Tu Shu‐Jiang , Li Guigen 
Published: September 2014

AbstractThe chemoselectivity of the reaction is controlled by the electronic effects of arylglyoxals and aromatic amines.
ChemInform Abstract: Synthesis and Photochromism of Novel Unsymmetrical Diarylethenes with an Azaindole Unit.
Authors: Sun Zhiyuan , Li Hui , Pu Shouzhi , Liu Gang , Chen Bing 
Published: September 2014

AbstractThe synthesized unsymmetrical photochromic diarylethenes exhibit fluorescence in solution and in PMMA films.
ChemInform Abstract: 6,7‐seco‐ent‐Kaurane Diterpenoids from Isodon sculponeatus and Their Bioactivity.
Authors: Jiang Hua‐Yi , Wang Wei‐Guang , Zhou Min , Wu Hai‐Yan , Zhan Rui , Du Xue , Pu Jian‐Xin , Sun Han‐Dong 
Published: September 2014

AbstractSculponin T (I) is isolated from the aerial parts of Isodon sculpneatus along with four known analogs.
ChemInform Abstract: Grevillosides J—Q, Arbutin Derivatives from the Leaves of Grevillea robusta and Their Melanogenesis Inhibitory Activity.
Authors: Yamashita‐Higuchi Yukiko , Sugimoto Sachiko , Matsunami Katsuyoshi , Otsuka Hideaki , Nakai Takahito 
Published: September 2014

AbstractNew arbutin derivatives grevillosides J—Q (I), (II), are isolated along with eight known compunds from the leaves of Grevillea robusta.
ChemInform Abstract: Stereoselective Total Synthesis of Cananginones (D—I) Using Ireland—Claisen Rearrangement as a Key Step.
Authors: Kuilya Tapan Kumar , Chatterjee Shamba , Goswami Rajib Kumar 
Published: September 2014

AbstractA strategy for the stereoselective total synthesis of cananginones D‐G (Ia)—(Id) and H‐I (II) is developed using D‐mannitol as chiral template.
ChemInform Abstract: Limonoids from Azadirachta indica var. siamensis Extracts and Their Cytotoxic and Melanogenesis‐Inhibitory Activities.
Authors: Akihisa Toshihiro , et al. et al. 
Published: September 2014

AbstractSix new limonoids (structure examples (I), (II), and (III)) together with 28 known limonoids and two known flavanoids are isolated and evaluated for their cytotoxic activities.
ChemInform Abstract: Synthesis and Biological Evaluation of 20‐Hydroxytriptonide and Its Analogues.
Authors: Xu Hongtao , Tang Huanyu , Yang Zhuo , Feng Huijin , Li Yuanchao 
Published: September 2014

AbstractThe natural product 20‐hydroxytriptonide (Ia) and its analogues triptonide (Ib), triptolide (IIa) and 5‐hydroxytriptolide (IIb) are synthesized and evaluated toward their cytotoxic activity.
ChemInform Abstract: The btp [2,6‐Bis(1,2,3‐triazol‐4‐yl)pyridine] Binding Motif: A New Versatile Terdentate Ligand for Supramolecular and Coordination Chemistry
Authors: Byrne Joseph P. , Kitchen Jonathan A. , Gunnlaugsson Thorfinnur 
Published: September 2014

AbstractReview: 164 refs.
ChemInform Abstract: Silica Functionalized Propyl Sulfonic Acid (SiO2‐Pr‐SO3H): An Efficient Catalyst in Organic Reactions
Authors: Gholamzadeh Parisa , Mohammadi Ziarani Ghodsi , Lashgari Negar , Badiei Alireza , Asadiatouei Paria 
Published: September 2014

AbstractReview: 175 refs.
ChemInform Abstract: Transfer Reaction Studies with Spectrometers
Authors: Szilner S. , Corradi L. , Pollarolo G. , Fioretto E. , Stefanini A. M. , de Angelis G. , Valiente‐Dobon J. J. , Farnea E. , Lunardi S. , Mengoni D. , et al. et al. 
Published: September 2014

AbstractReview: 22 refs.
From Antidiabetic to Antifungal: Discovery of Highly Potent Triazole–Thiazolidinedione Hybrids as Novel Antifungal Agents
Authors: Wu Shanchao , Zhang Yongqiang , He Xiaomeng , Che Xiaoying , Wang Shengzheng , Liu Yang , Jiang Yan , Liu Na , Dong Guoqiang , Yao Jianzhong , Miao Zhenyuan , Wang Yan , Zhang Wannian , Sheng Chunquan 
Published: September 2014

AbstractIn an attempt to discover a new generation of triazole antifungal agents, a series of triazole–thiazolidinedione hybrids were designed and synthesized by molecular hybridization of the antifungal agent fluconazole and rosiglitazone (an antidiabetic). Most of the target compounds showed good to excellent inhibitory activity against a variety of clinically important fungal pathogens. In particular, compounds (Z)‐5‐(2,4‐dichlorobenzylidene)‐3‐(2‐(2,4‐difluorophenyl)‐2‐hydroxy‐3‐(1H‐1,2,4‐triazol‐1‐yl)propyl)thiazolidine‐2,4‐dione) (15 c), (Z)‐3‐(2‐(2,4‐difluorophenyl)‐2‐hydroxy‐3‐(1H‐1,2,4‐triazol‐1‐yl)propyl)‐5‐(furan‐3‐ylmethylene)thiazolidine‐2,4‐dione (15 j), and (Z)‐3‐(2‐(2,4‐difluorophenyl)‐2‐hydroxy‐3‐(1H‐1,2,4‐triazol‐1‐yl)propyl)‐5‐(furan‐3‐ylmethylene)thiazolidine‐2,4‐dione (15 r) were highly active against Candida albicans, with MIC80 values in the range of 0.03–0.15 μM. Moreover, compounds 15 j and 15 r were found to be effective against four fluconazole‐resistant clinical isolates; these two compounds are particularly promising antifungal leads for further optimization. Molecular docking studies revealed that the hydrogen bonding interactions between thiazolidinedione and CYP51 from C. albicans are important for antifungal activity. This study also demonstrates the effectiveness of molecular hybridization in antifungal drug discovery.
Quinone‐Rich Poly(dopamine) Magnetic Nanoparticles for Biosensor Applications
Authors: Martín Miriam , González Orive Alejandro , Lorenzo‐Luis Pablo , Hernández Creus Alberto , González‐Mora José Luis , Salazar Pedro 
Published: September 2014

AbstractNovel core‐shell quinone‐rich poly(dopamine)–magnetic nanoparticles (MNPs) were prepared by using an in situ polymerization method. Catechol groups were oxidized to quinone by using a thermal treatment. MNPs were characterized by using X‐ray diffraction, X‐ray photoelectron spectroscopy, atomic force microscopy, magnetic force microscopy, UV/Vis, Fourier‐transform infrared spectroscopy, and electrochemical techniques. The hybrid nanomaterial showed an average core diameter of 17 nm and a polymer‐film thickness of 2 nm. The core‐shell nanoparticles showed high reactivity and were used as solid supports for the covalent immobilization of glucose oxidase (Gox) through Schiff base formation and Michael addition. The amount of Gox immobilized onto the nanoparticle surface was almost twice that of the nonoxidized film. The resulting biofunctionalized MNPs were used to construct an amperometric biosensor for glucose. The enzyme biosensor has a sensitivity of 8.7 mA M−1 cm−2, a low limit of detection (0.02 mM), and high stability for 45 days. Finally, the biosensor was used to determine glucose in blood samples and was checked against a commercial glucometer.
Oxygen‐Plasma‐Functionalized Carbon Nanotubes as Supports for Platinum–Ruthenium Catalysts Applied in Electrochemical Methanol Oxidation
Authors: Chetty Raghuram , Maniam Kranthi Kumar , Schuhmann Wolfgang , Muhler Martin 
Published: September 2014

AbstractMultiwalled carbon nanotubes (CNTs) functionalized by oxygen plasma were used as a support for platinum–ruthenium nanoparticles for electrochemical methanol oxidation. The influence of plasma treatment time on the electrocatalytic activity was investigated by cyclic voltammetry, CO stripping voltammetry, and chronoamperometry. The electrocatalysts were characterized by Raman spectroscopy, X‐ray photoelectron spectroscopy, scanning electron microscopy, transmission electron microscopy, and X‐ray diffraction. The results showed that oxygen plasma treatment led to the formation of CO and COO groups on the CNT surface. Platinum–ruthenium nanoparticles dispersed with an optimum plasma treatment time of 30 min exhibited the maximum catalytic activity towards methanol oxidation. The rationale for the high catalytic activity is discussed.