bluuebunny/crossref_metadata_2025_split huggingface dataset:
Competing institutional logics in the development and implementation of integrated treatment for concurrent disorders in Ontario: A case study
Authors: Novotná Gabriela 
Published: March 2013

Summary Rising health care costs have increased scrutiny on the performance of mental health and substance use services. The specifics of these human service organizations’ institutional environments make evaluating their organizational performance a challenging task. This study, based on 27 semi-structured interviews, document analyses and non-participant observation at two treatment programs, explored how two different institutional logics – managerial strategies striving for treatment effectiveness and client-centered care – guide the implementation of integrated treatment for concurrent disorders in Ontario, Canada. Findings Treatment services for concurrent disorders have been pressured to adopt more business-like, performance-oriented rationales that are part of corporatist institutional paradigms including, for example, the spread of managerial strategies focused on developing strong performance culture. Such development, however, can conflict with the principles of client-centered, comprehensive care that social workers and other helping professions adhere to. In this regard, the clash of different rationalities brings inconsistencies to the process of developing and implementing integrated treatments for concurrent disorders. Applications Despite the ideological commitment to comprehensive, individually-tailored and continuous treatment for concurrent disorders, there has been tension between such commitment and the emphasis on abbreviated, manual-based, routinized treatments associated with cost-containment and resource efficiency. This, however, can have serious consequences for treatment planning and treatment delivery, the client-clinician relationship and the displacement of client-centered care by program-centered approaches.
Readiness of boards of trustees in non-profit and voluntary sector organisations to meet the adult care ‘personalisation agenda’: A case study of a single English county
Authors: Donovan Ben , Gilbert Tony , Moran Beth , Stanley Selwyn , Barnett Samantha , Hocking Dave 
Published: March 2013

Summary In a multi-method assessment of non-profit and voluntary sector governance in Cornwall, England, 65 chairpersons of organisations completed a Board Self-Assessment Questionnaire (BSAQ) to identify the level at which the board was functioning. They also commented on their awareness of the Westminster Government's personalisation agenda. In addition, semi-structured interviews were undertaken with 17 board representatives from seven organisations to explore organisational support needs in respect of meeting the Adult Care ‘personalisation agenda’. Findings Board members who reported good awareness of the personalisation agenda also self-assessed themselves as scoring higher than other respondents on the six BSAQ factors. Multiple regression analysis indicated that 47% of the variation in personalisation agenda preparedness was accounted for by organisations’ BSAQ scores. Qualitative data highlighted a number of important issues that may impact on the successful development of the personalisation agenda. These included the difficulty voluntary boards have in attracting trustees with appropriate experience, blurring of roles where trustees take on multiple roles some with operational commitments and communication difficulties with the local authority that results in board members stating that they are not sure of what is expected. Applications While the study focussed on a single county the demographic of non-profit and voluntary sector organisations are not dissimilar from other areas which provide some basis for generalisability. Findings also resonate with previous studies of the sector. This suggests that local authorities and adult social care departments have considerable challenges to ensure the readiness of organisations in the sector and the robustness of governance delivered via trustees.
Civic practice: A new professional paradigm for social work
Authors: Harington Philip RJ , Beddoe Liz 
Published: March 2013

• Summary: Economic rationalism has had an impact upon the position of many professions in Western society. Drawing on New Zealand material this article argues that neoliberal targeting of professions’ capacity to capture domains of service and their funding has fuelled deprofessionalization, but also created space for alternative domains of practice. A case for a civic model of social work practice is argued. • Findings: Debates about the nature of professions flourish in current literature. An exploration of the features of the social work profession suggests three types: heroic, altruistic and civic. The development of civic practice in social work is suggested, presupposing a reframing of the role and focus of the profession toward social inquiry applied to the rights and needs of citizens. • Application: The contribution of this article is to explore a move forward in the de-professionalization debates and to propose a civic social work grounded in advocacy and critical social inquiry.
Is percentage theatre utilisation data an accurate predictor of cost-effectiveness and performance in urology?
Authors: Modgil V , Gordon K , Mak D , Liu S , Gommersall L 
Published: March 2013

Objective: The current economic and political climate demands a focus on efficiency and productivity, whilst delivering quality, across all aspects of the National Health Service (NHS). Operative theatres act as a critical, yet costly resource. The Audit Commission employs the use of percentage theatre utilisation as a principal measure of NHS operating theatre service and efficiency performance. We analysed theatre utilisation data in a five-consultant, high turnover, urology department within a NHS University Teaching Hospital. Our aim was to examine the relationship between theatre utilisation data, cost effectiveness and income generated. Patients and methods: Data on the usage of a dedicated urology theatre was collected over 251 hours for a full calendar month. A total of 176 consecutive procedures were performed. Linear regression analysis was performed to assess the correlation between number of operating hours, cases per hour, utilisation percentages and income generated. Results: There was no correlation between percentage theatre utilisation and income ( R2=0.0191, p=0.82). No relationship was identified between percentage theatre utilisation and total number of cases performed ( R2=0.0001, p=0.99). Although there appeared to be a positive correlation between the number of cases performed and income generated, this was not statistically significant ( R2=0.725, p=0.067). Furthermore, there was no association between the number of cases performed per hour and income generated ( R2=0.3184, p=0.32). Conclusion: Our data identifies no correlation between percentage theatre utilisation, income generated and number of cases performed. Utilisation percentages are not a reliable performance indicator when used in isolation, and therefore should be used as part of a more global picture when assessing cost effectiveness and efficiency performance.
Extracellular protein disulfide isomerase regulates ligand-binding activity of αMβ2 integrin and neutrophil recruitment during vascular inflammation
Authors: Hahm Eunsil , Li Jing , Kim Kyungho , Huh Sungjin , Rogelj Snezna , Cho Jaehyung 
Published: March 2013

Key PointsThis work is the first identification of a neutrophil surface thiol isomerase regulating adhesive function of αMβ2 integrin. PDI is required for neutrophil recruitment during vascular inflammation and its isomerase activity is critical for the regulatory effect.
Targeting B-cell anergy in chronic lymphocytic leukemia
Authors: Apollonio Benedetta , Scielzo Cristina , Bertilaccio Maria Teresa Sabrina , ten Hacken Elisa , Scarfò Lydia , Ranghetti Pamela , Stevenson Freda , Packham Graham , Ghia Paolo , Muzio Marta , Caligaris-Cappio Federico 
Published: March 2013

Key Points
A sizable fraction of CLL patients is characterized by the expansion of clonal B cells with anergic features. The constitutive biochemical signature of B-cell anergy can be efficiently targeted in CLL for therapeutic purposes.
Homomorphisms and derivations in induced fuzzy "Equation missing" -algebras
Authors: Azadi Kenary Hassan , Ghirati Mojtaba , Park Choonkil , Eshaghi Gordji Madjid 
Published: March 2013

Abstract
Using fixed point method, we establish the Hyers-Ulam stability of fuzzy ∗-homomorphisms in fuzzy

C
∗

-algebras and fuzzy ∗-derivations on fuzzy

C
∗

-algebras associated to the following

(
m
,
n
)

-Cauchy-Jensen additive functional equation:

∑

1
≤

i
1

<
⋯
<

i
m

≤
n

1
≤

k
l

(
≠

i
j

,
∀
j
∈
{
1
,
…
,
m
}
)
≤
n

f

(

∑

j
=
1

m

x

i
j

m

+

∑

l
=
1

n
−
m

x

k
l

)

=

(
n
−
m
+
1
)

n

(

n
m

)

∑

i
=
1

n

f
(

x
i

)
.

MSC:47S40, 39B52, 46S40, 47H10, 26E50.
Personality traits in chronic daily headache patients with and without psychiatric comorbidity: an observational study in a tertiary care headache center
Authors: Rausa Marialuisa , Cevoli Sabina , Sancisi Elisa , Grimaldi Daniela , Pollutri Gabriella , Casoria Michela , Grieco Daniela , Bisi Alberto , Cortelli Pietro , Pozzi Euro , Pierangeli Giulia 
Published: March 2013

Abstract

Background
Previous studies suggest that patients with Chronic Daily Headache (CDH) have higher levels of anxiety and depressive disorders than patients with episodic migraine or tension-type headache. However, no study has considered the presence of psychiatric comorbidity in the analysis of personality traits. The aim of this study is to investigate the prevalence of psychiatric comorbidity and specific personality traits in CDH patients, exploring if specific personality traits are associated to headache itself or to the psychiatric comorbidity associated with headache.

Methods
An observational, cross-sectional study. Ninety-four CDH patients with and without medication overuse were included in the study and assessed by clinical psychiatric interview and Mini International Neuropsychiatric Interview (M.I.N.I.) as diagnostic tools. Minnesota Multiphasic Personality Inventory-2 (MMPI-2), Hamilton Depression Rating Scale (HAM-D) were afterwards administered. Patients with and without psychiatric comorbidity were compared. Further analyses were made by splitting the whole group according to the headache diagnosis and the presence or not of medication overuse.

Results
Psychiatric comorbidity was detected in 44 patients (46.8%) (group A) and was absent in the remaining 50 patients (53.2%) (group B). Mood and anxiety disorders were the most frequently diagnosed (43.6%).
In the overall group, mean scores of MMPI-2 showed a high level in the so-called neurotic triad; in particular the mean score in the Hypochondriasis subscale was in the pathologic area (73.55 ± 13.59), while Depression and Hysteria scores were moderate but not severe (62.53 and 61.61, respectively). In content scales, score in Health Concern was also high (66.73).
Group A presented higher scores compared to Group B in the following MMPI-2 subscales: Hypochondriasis (p = .036), Depression (p = .032), Hysteria (p < .0001), Hypomania (p = .030). Group B had a high score only in the Hypochondriasis subscale. No significant differences were found between chronic migraine (CM)-probable CM (pCM) plus probable medication overuse headache (pMOH) and chronic tension-type headache (CTTH)-probable CTTH (pCTTH) plus pMOH patients or between patients with and without drug overuse.

Conclusions
The so-called “Neurotic Profile” reached clinical level only in CDH patients with psychiatric comorbidity while a high concern about their general health status was a common feature in all CDH patients.
GenePainter: a fast tool for aligning gene structures of eukaryotic protein families, visualizing the alignments and mapping gene structures onto protein structures
Authors: Hammesfahr Björn , Odronitz Florian , Mühlhausen Stefanie , Waack Stephan , Kollmar Martin 
Published: March 2013

Abstract

Background
All sequenced eukaryotic genomes have been shown to possess at least a few introns. This includes those unicellular organisms, which were previously suspected to be intron-less. Therefore, gene splicing must have been present at least in the last common ancestor of the eukaryotes. To explain the evolution of introns, basically two mutually exclusive concepts have been developed. The introns-early hypothesis says that already the very first protein-coding genes contained introns while the introns-late concept asserts that eukaryotic genes gained introns only after the emergence of the eukaryotic lineage. A very important aspect in this respect is the conservation of intron positions within homologous genes of different taxa.

Results
GenePainter is a standalone application for mapping gene structure information onto protein multiple sequence alignments. Based on the multiple sequence alignments the gene structures are aligned down to single nucleotides. GenePainter accounts for variable lengths in exons and introns, respects split codons at intron junctions and is able to handle sequencing and assembly errors, which are possible reasons for frame-shifts in exons and gaps in genome assemblies. Thus, even gene structures of considerably divergent proteins can properly be compared, as it is needed in phylogenetic analyses. Conserved intron positions can also be mapped to user-provided protein structures. For their visualization GenePainter provides scripts for the molecular graphics system PyMol.

Conclusions
GenePainter is a tool to analyse gene structure conservation providing various visualization options. A stable version of GenePainter for all operating systems as well as documentation and example data are available at http://www.motorprotein.de/genepainter.html.
The interaction of Kinesin-1 with its adaptor protein JIP1 can be regulated via proteins binding to the JIP1-PTB domain
Authors: Satake Tomoko , Otsuki Karin , Banba Yumi , Suenaga Jun , Hirano Hisashi , Yamanaka Yuko , Ohno Shigeo , Hirai Syu-ichi 
Published: March 2013

Abstract

Background
The regulatory mechanisms of motor protein-dependent intracellular transport are still not fully understood. The kinesin-1-binding protein, JIP1, can function as an adaptor protein that links kinesin-1 and other JIP1-binding “cargo” proteins. However, it is unknown whether these “cargo” proteins influence the JIP1–kinesin-1 binding.

Results
We show here that JIP1–kinesin-1 binding in Neuro2a cells was dependent on conserved amino acid residues in the JIP1-phosphotyrosine binding (PTB) domain, including F687. In addition, mutation of F687 severely affected the neurite tip localization of JIP1. Proteomic analysis revealed another kinesin-1 binding protein, JIP3, as a major JIP1 binding protein. The association between JIP1 and JIP3 was dependent on the F687 residue in JIP1, and this association induced the formation of a stable ternary complex with kinesin-1. On the other hand, the binding of JIP1 and JIP3 was independent of kinesin-1 binding. We also show that other PTB binding proteins can interrupt the formation of the ternary complex.

Conclusions
The formation of the JIP1–kinesin-1 complex depends on the protein binding-status of the JIP1 PTB domain. This may imply a regulatory mechanism of kinesin-1-dependent intracellular transport.
A variance component based multi-marker association test using family and unrelated data
Authors: Wang Xuefeng , Morris Nathan J , Zhu Xiaofeng , Elston Robert C 
Published: March 2013

Abstract

Background
Incorporating family data in genetic association studies has become increasingly appreciated, especially for its potential value in testing rare variants. We introduce here a variance-component based association test that can test multiple common or rare variants jointly using both family and unrelated samples.

Results
The proposed approach implemented in our R package aggregates or collapses the information across a region based on genetic similarity instead of genotype scores, which avoids the power loss when the effects are in different directions or have different association strengths. The method is also able to effectively leverage the LD information in a region and it can produce a test statistic with an adaptively estimated number of degrees of freedom. Our method can readily allow for the adjustment of non-genetic contributions to the familial similarity, as well as multiple covariates.

Conclusions
We demonstrate through simulations that the proposed method achieves good performance in terms of Type I error control and statistical power. The method is implemented in the R package “fassoc”, which provides a useful tool for data analysis and exploration.
SMART – Sunflower Mutant population And Reverse genetic Tool for crop improvement
Authors: Kumar Anish PK , Boualem Adnane , Bhattacharya Anjanabha , Parikh Seema , Desai Nirali , Zambelli Andres , Leon Alberto , Chatterjee Manash , Bendahmane Abdelhafid 
Published: March 2013

Abstract

Background
Sunflower (Helianthus annuus L.) is an important oilseed crop grown widely in various areas of the world. Classical genetic studies have been extensively undertaken for the improvement of this particular oilseed crop. Pertaining to this endeavor, we developed a “chemically induced mutated genetic resource for detecting SNP by TILLING” in sunflower to create new traits.

Results
To optimize the EMS mutagenesis, we first conducted a “kill curve” analysis with a range of EMS dose from 0.5% to 3%. Based on the observed germination rate, a 50% survival rate i.e. LD50, treatment with 0.6% EMS for 8 hours was chosen to generate 5,000 M2 populations, out of which, 4,763 M3 plants with fertile seed set. Phenotypic characterization of the 5,000 M2 mutagenised lines were undertaken to assess the mutagenesis quality and to identify traits of interest. In the M2 population, about 1.1% of the plants showed phenotypic variations. The sunflower TILLING platform was setup using Endo-1-nuclease as mismatch detection system coupled with an eight fold DNA pooling strategy. As proof-of-concept, we screened the M2 population for induced mutations in two genes related to fatty acid biosynthesis, FatA an acyl-ACP thioesterase and SAD the stearoyl-ACP desaturase and identified a total of 26 mutations.

Conclusion
Based on the TILLING of FatA and SAD genes, we calculated the overall mutation rate to one mutation every 480 kb, similar to other report for this crop so far. As sunflower is a plant model for seed oil biosynthesis, we anticipate that the developed genetic resource will be a useful tool to identify novel traits for sunflower crop improvement.
Rate of candidiasis among HIV-infected children in Spain in the era of highly active antiretroviral therapy (1997–2008)
Authors: Álvaro-Meca Alejandro , Jensen Julia , Micheloud Dariela , Díaz Asunción , Gurbindo Dolores , Resino Salvador 
Published: March 2013

Abstract

Background
Candidiasis is the most common opportunistic infection seen in human immunodeficiency virus (HIV)-infected individuals. The aim of our study was to estimate the candidiasis rate and evaluate its trend in HIV-infected children in Spain during the era of highly active antiretroviral therapy (HAART) compared to HIV-uninfected children.

Methods
We carried out a retrospective study. Data were obtained from the records of the Minimum Basic Data Set from hospitals in Spain. All HIV-infected children were under 17 years of age, and a group of HIV-uninfected children with hospital admissions matching the study group by gender and age were randomly selected. The follow-up period (1997–2008) was divided into three calendar periods: a) From 1997 to 1999 for early-period HAART; b) from 2000 to 2002 for mid-period HAART; and c) from 2003 to 2008 for late-period HAART.

Results
Among children with hospital admissions, HIV-infected children had much higher values than HIV-uninfected children during each of the three calendar periods for overall candidiasis rates (150.0 versus 6.1 events per 1,000 child hospital admissions/year (p < 0.001), 90.3 versus 3.1 (p < 0.001), and 79.3 versus 10.7 (p < 0.001), respectively) and for non-invasive Candida mycosis (ICM) rates (118.5 versus 3.8 (p < 0.001), 85.3 versus 2.3 (p < 0.001), and 80.6 versus 6.0 (p < 0.001), respectively). In addition, HIV-infected children also had higher values of ICM rates than HIV-uninfected children, except during the last calendar period when no significant difference was found (32.4 versus 1.2 (p < 0.001), 11.6 versus 0.4 (p < 0.001), and 4.6 versus 2.3 (p = 0.387), respectively). For all children living with HIV/AIDS, the overall candidiasis rate (events per 1,000 HIV-infected children/year) decreased from 1997–1999 to 2000–2002 (18.8 to 10.6; p < 0.001) and from 2000–2002 to 2003–2008 (10.6 to 5.7; p = 0.060). Within each category of candidiasis, both non-ICM and ICM rates experienced significant decreases from 1997–1999 to 2003–2008 (15.9 to 5.7 (p < 0.001) and 4.1 to 0.3 (p < 0.001), respectively).

Conclusions
Although the candidiasis rate still remains higher than in the general population (from 1997 to 2008), candidiasis diagnoses have decreased among HIV-infected children throughout the HAART era, and it has ceased to be a major health problem among children with HIV infection.
Immune response, antibody persistence, and safety of a single dose of the quadrivalent meningococcal serogroups A, C, W-135, and Y tetanus toxoid conjugate vaccine in adolescents and adults: results of an open, randomised, controlled study
Authors: Borja-Tabora Charissa , Montalban Cecilia , Memish Ziad A , Van der Wielen Marie , Bianco Veronique , Boutriau Dominique , Miller Jacqueline 
Published: March 2013

Abstract

Background
The best strategy to protect individuals against meningococcal disease is to immunize against multiple serogroups. Immunogenicity, antibody persistence, and safety of the EU-licensed meningococcal ACWY-tetanus toxoid conjugate vaccine (MenACWY-TT) were evaluated in healthy participants aged 11–55 years from the Philippines and Saudi Arabia.

Methods
In this phase IIb, open, controlled study, 500 participants were randomised (3:1) to receive one dose of MenACWY-TT or a licensed meningococcal polysaccharide vaccine (Men-PS). Functional antibody responses against meningococcal serogroups A, C, W-135, and Y were assessed by a serum bactericidal antibody assay using rabbit complement (rSBA) at Month 0, Month 1, Year 1, Year 2, and Year 3. Vaccine response was defined as an rSBA titre ≥32 at Month 1 in participants who were seronegative (rSBA titre <8) pre-vaccination and as at least a four-fold increase in titre in participants who were seropositive pre-vaccination. Solicited symptoms were recorded up to Day 4, safety outcomes up to Month 6, and serious adverse events related to vaccination up to Year 3.

Results
Pre-specified criteria for non-inferiority of MenACWY-TT versus Men-PS were met in terms of rSBA vaccine response and incidence of grade 3 general symptoms. At Month 1, 82.7%–96.3% of MenACWY-TT and 69.7%–91.7% in Men-PS recipients had a vaccine response for each serogroup. At Year 3, ≥99.1% and ≥92.9% of MenACWY-TT recipients retained rSBA titres ≥8 and ≥128, respectively, as compared to ≥86.7% and ≥80.0% in the Men-PS group. Both vaccines had a clinically acceptable safety profile, although injection site redness and swelling were more frequent in MenACWY-TT recipients.

Conclusions
These results suggest that MenACWY-TT could protect adolescents and adults against meningococcal disease up to three years post-vaccination.

Trial registration
This study is registered at http://www.clinicaltrials.gov/NCT00356369.