bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pseudolymphoma Syndrome due to Carbamazepine
Authors: Saeki Hidehisa , Etoh Takafumi , Toda Kiyoshi , Mihm Martin C. 
Published: April 2015

AbstractWe described a 29‐year‐old Japanese woman with a pseudolymphoma syndrome due to carbamazepine. Physical examination revealed a diffuse erythematous papular eruption over almost all of her body with generalized lymphadenopathy. Histopathologic examination disclosed histology compatible with the nodular pattern of pseudo‐T‐cell lymphoma. The Southern blot analysis did not disclose the monoclonality of the gamma T cell recepter gene. We consider that it is very important to recognize this pseudolymphoma syndrome due to carbamazepine to avoid possibly subjecting the patient to unnecessary chemotherapy.
Annular Vasculitis in Association with Sarcoidosis
Authors: Cecchi Roberto , Giomi Andrea 
Published: April 2015

AbstractWe report a case of cutaneous vasculitis with annular features in association with sarcoidosis. A 36‐year‐old woman presented with fever, polyarthralgias, erythema nodosum, bilateral hilar lymphadenopathy, and induration of a long‐standing scar on the face. In addition, she developed annular, erythematous, and purpuric patches over her thighs and buttocks that were histologically characterized by a small vessel leukocytoclastic vasculitis. The presence of circulating immune complexes in the early stages of sarcoidosis might be related to the occurrence of the vascular damage.
Cellular Neurothekeoma with Possible Neuroendocrine Differentiation
Authors: Chang Sung‐Eun , Lee Tae‐Jin , Ro Jae Y. , Choi Jee‐Ho , Sung Kyung‐Jeh , Moon Kee‐Chan , Koh Jai‐Kyoung 
Published: April 2015

AbstractWe report a case of cellular neurothekeoma showing unusual immunohistochemical findings and occurring on the left upper arm of a healthy 48‐year‐old woman. She presented with a 1 cm, red, asymptomatic, dermal nodule of 1 year duration. A biopsy showed dermal proliferation of plexiform fascicles of spindle‐shaped or polygonal cells with plentiful eosinophilic cytoplasms. The immunohistochemical profile included negative stains for S‐100, CD34, factor XIIa, CD68, HMB45, cytokeratins, and EMA, strongly positive stains for neuron specific enolase (NSE), synaptophysin, and chromogranin A, and focally positive ones for NKI/C3 and α‐smooth muscle actin. Ultrastructural analysis showed undifferentiated mesenchymal cells with cytoplasmic projections and abundant RER. Although we couldn't find any confirmative cell type in this cellular tumor, we believe that cellular neurothekeoma is predominantly composed of undifferentiated cells that can exhibit features of neuroendocrine cells in addition to fibroblastic or myofibroblastic ones, suggesting a divergent cell origin.
Two Cases of Gigantic Dystrophic Calcinosis Cutis Caused by Subcutaneous and/or Intramuscular Injections
Authors: Kanda Akira , Uchimiya Hiroshi , Ohtake Naoki , Setoyama Misturu , Kanzaki Tamotsu 
Published: April 2015

AbstractWe describe two female patients with gigantic dystrophic calcinosis cutis caused by a large number of sunbcutaneous and/or intramuscular injections which they received when they were much younger. Laboratory data and physical examinations were generally within normal limits, and we detected no disease which might induce cutaneous calcification. There are many reports of dystrophic calcinosis cutis caused by injection of several kinds of drugs. However, we found no previous report describing a patient with calcinosis cutis induced by local tissue injury from a large number of injections and with extraordinarily widespread calcification at the injection sites. Because we do not know the exact drugs injected, it is difficult to say if a specific ingredient in the injections was related to this condition. We do know that a large number of subcutaneous or intramuscular injections were frequently administered to patients who had difficulty in maintaining venous infusions in the past, so there may be similar cases of dystrophic calcinosis cutis which have not been reported.
A Case of Cutaneous Extramedullary Hematopoiesis in Myelofibrosis with a Preponderance of Eosinophilic Precursor Cells
Authors: Kwon Kyung‐Sool , Lee Jae‐Bong , Jang Ho‐Sun , Chung Tae‐Ahn , Oh Chang‐Keun 
Published: April 2015

AbstractA 48‐year‐old Korean man with myelofibrosis had erythematous papules and nodules on his scalp, anterior chest, back, lower abdomen, and both thighs. Skin biopsy showed cellular infiltration on the perivascular dermis and subcutaneous fat. Infiltrates were composed mainly of myeloid cells, especially of eosinophilic precursor cells. Erythroid and a few megakaryocyte precursors were also found. We diagnosed cutaneous extramedullary hematopoiesis with an interesting preponderance of eosinophile precursor cells.
Adenocarcinoma with Signet Ring Cells of the Axilla: Two Case Reports and Review of the Literature
Authors: Kuno Yoshinori , Tsuji Takuo , Yamamoto Keizo 
Published: April 2015

AbstractAdenocarcinoma with signet ring cells (ASRC) is a rare skin neoplasm whose histology shows a solid tumor intermingled with signet ring cells in variable numbers. There have been only ten reported cases. All were elderly males affected on the eyelids except for a single case in the axilla. Two new patients with ASRC of the axilla are described. In both of them, immunohistochemical studies revealed neoplastic cells that had differentiated toward apocrine glands. These are the second and third reported cases of ASRC in the axilla, one of them is the first ASRC case in a female. It seemed that the apocrine sweat gland or aberrant breast tissue in the axilla were possible origins of these tumors.
Juvenile Chronic Myelogenous Leukemia, Neurofibromatosis 1, and Xanthoma
Authors: Jang Kyoung‐Ae , Choi Jee‐Ho , Sung Kyung‐Jeh , Moon Kee‐Chan , Koh Jai‐Kyoung , Im Dong‐Jin 
Published: April 2015

AbstractThe triple association of leukemia, xanthomatous skin lesions, and neurofibromatosis 1 (NF) was first described by Royer et al. in 1958. Most of the leukemias were of the juvenile chronic myelogenous type (JCML). We describe a 7‐year‐old male child with xanthoma, neurofibromatosis 1, and juvenile chronic myelogenous leukemia. His mother also had NF1. We suggest that the presence of xanthomas and NF1 in a young child should raise awareness of the possible development of JCML, especially in patients with a family history of NF1.
Localized Soft Tissue Angiomatosis with Subsequent Development of Angiolymphoid Hyperplasia with Eosinophilia
Authors: Misago Noriyuki , Tanaka Taturou , Kodera Hanako , Narisawa Yutaka 
Published: April 2015

AbstractWe report an unusual case of arteriovenous (AV) malformation (localized form of soft tissue angiomatosis): a reaction of angiolymphoid hyperplasia with eosinophilia (ALHE) developed over the lesion of this pre‐existing AV malformation. To the best of our knowledge, there is no other report of ALHE in association with a pre‐existing bona fide AV malformation. A 71‐year‐old woman consulted our clinic because a reddish, dome‐shaped tumor on her preauricular region, present as a slightly elevated, skin‐colored tumor since her childhood, had rapidly enlarged and become more elevated with color change during the preceding two months. The histological features of most of the lesion corresponded to those of soft tissue angiomatosis (localized form). The proliferative vessels underlying the soft tissue angiomatosis streamed out and welled into the dermis with an accompanying prominent inflammatory infiltrate composed of lymphoid cells and eosinophils: these histological features were characteristic of ALHE. The recent abrupt clinical changes in the tumor were considered to represent a reaction to the angiomatosis with development of ALHE.
Acanthotic Type of Eccrine Poroma on the Arm: Report of a Case
Authors: Ohno Tomoya , Ueda Daizo , Koike Shun'ichi , Dekio Satoshi , Jidoi Joji 
Published: April 2015

AbstractA 72‐year‐old Japanese man with eccrine poroma on the arm is described. To the best of our knowledge, he is the fifth patient with this tumor on the arm reported from Japan. The histopathological type of the tumor of our patient was unique because it was acanthotic; those of the previous patients were all of the intradermal type.
Intraepidermal Expression of Basement Membrane Components in the Lesional Skin of a Patient with Dystrophic Epidermolysis Bullosa
Authors: Muramatsu Tsutomu , Ko Toshiko , Honoki Kumiko , Hatoko Mituso , Shirai Toshihiko , Vnittanakom Pramote 
Published: April 2015

AbstractThe patient was a 15‐year‐old male. Since birth, he had developed blistering and erosion of the skin. Biopsy skin specimen of the bullous lesions showed subepidermal blister formation. Electron microscopic examination revealed that tissue separation had occurred at the sublamina densa level. By indirect immunofluorescence using antibodies specific for α6 integrin, laminin 5, type IV collagen, and type VII collagen, all of these basement membrane components were detected as coarse granular intracytoplasmic deposits only in the basal and suprabasal cells of the blister roof. In the non‐blistered regions, these basement membrane components showed a linear pattern similar to that seen in normal skin. These findings suggest that intraepidermal expression of basement membrane components was closely related to the blister formation. The biological meaning of intraepidermal expression of basement membrane components were also discussed.
Subcutaneous Emphysema with Spontaneous Pneumomediastinum and Pneumothorax in Adult Dermatomyositis
Authors: Jang Kyoung‐Ae , Kim So‐Hyung , Choi Jee‐Ho , Sung Kyung‐Jeh , Moon Kee‐Chan , Koh Jai‐Kyoung 
Published: April 2015

AbstractWe describe a 32‐year‐old patient with adult dermatomyositis who developed dyspnea and worsening of pre‐existing infarcted skin lesions of the fingers. Chest radiographs showed diffuse hazy reticulonodular infiltration in both lungs, subcutaneous emphysema, pneumomediastinum, and pneumothorax. The pulmonary symptoms and cutaneous lesions gradually improved with a high dose of prednisolone. Although subcutaneous emphysema and pneumomediastinum occur frequently in association with traumatic disruption of cutaneous and mucosal barriers and assisted ventilation, it has rarely been observed in patients with interstitial pneumonitis in connective tissue diseases. Although dermatomyositis and subcutaneous emphysema are all relatively well‐known diseases to dermatologists, the occurrence of spontaneous pneumomediastinum and pneumothorax and subsequent subcutaneous emphysema in connective tissue diseases such as dermatomyositis is unfamiliar. We discuss the possible mechanisms of this condition.
Palmoplantar Keratoderma (Voerner) with Composite Keratohyalin Granules: Studies on Keratinization Parameters and Ultrastructures
Authors: Hashimoto Ken , Mizuguchi Richard , Tanaka Kazuaki , Dorman Michael 
Published: April 2015

AbstractA case of the Voerner type palmoplantar keratoderma was studied for abnormalities of keratinization parameters. An enzyme and materials used to build the marginal band or cellular envelope of the cornified cell were all abnormally expressed; i.e. transglutaminase I (TGK), loricrin, and involucrin were abnormally immunostained. In the normal controls, their expression was limited to the upper epidermis, mainly in the granular layer. In the lesional skin, they were detected from the suprabasal layer to the lower horny layer. Filaggrin, the protein of the keratohyalin granule, was also expressed more widely than in controls. Ultrastructural abnormalities included a significantly higher frequency of composite keratohyalin granules than controls, early formation of a marginal band in the midepidermis, and, most remarkably, the clumping of tonofilaments causing vacuolization of the cytoplasm of affected keratinocytes.
Repeated 5–Aminolevulinic Acid‐Based Photodynamic Therapy Following Electro‐Curettage for Pigmented Basal Cell Carcinoma
Authors: Itoh Yoshiyasu , Henta Tetsuro , Ninomiya Yoshiharu , Tajima Shingo , Ishibashi Akira 
Published: April 2015

Abstract5–Aminolevulinic acid‐based photodynamic therapy (ALA‐PDT) in the standard manner is ineffective for pigmented basal cell carcinoma (pBCC), because melanin absorbs the photoactivating light interred for protoporphyrin IX. The objective of this study was to assess the therapeutic outcome of pBCCs with repeated ALA‐PDT following removal of pigmentation with electro‐curettage. After electro‐curettage, 16 pBCCs were treated with a combination of topical application of 20% ALA in O/W emulsion and topical instillation of 10% ALA solution, followed by photoactivating light. ALA‐PDT was performed more than three times. Fourteen of 16 pBCCs showed CR. Two pBCCs showing PR or NR were excised. Repeated ALA‐PDT following electro‐curettage was effective for pBCC.
Trichotillomania and Trichophagia Leading to Trichobezoar
Authors: Sharma Nand Lal , Sharma Ramesh Chander , Mahajan Vikram Kumar , Sharma Ravi Chand , Chauhan Dayal , Sharma Ashok Kumar 
Published: April 2015

AbstractA 14‐year‐old female presented with the complaints of loss of hair, scalp pruritus, and pain in the abdomen. On careful work‐up, she was found to have trichotillomania as well as trichophagia. Investigations also revealed a trichobezoar which completely filled the stomach. Hemogram showed moderate hypochromic anemia. Her detailed psychiatric profile showed a few additional features like obsessive hand washing, knuckle cracking, nose picking and body rocking. Her trichobezoar was removed surgically, and she had an uneventful post‐operative recovery. She is being maintained on fluoxetine and is doing well. The role of a multi‐disciplinary approach to trichotillomania patients is highlighted.
A Case of Linear Scleroderma and Myasthenia Gravis
Authors: Kim Hee Sung , Chun Yoon‐Sun , Hann Seung‐Kyung , Park Wook‐Hwa 
Published: April 2015

AbstractWe report a case of a 28‐year‐old woman with myasthenia gravis who developed linear scleroderma seven years later. Myasthenia gravis and scleroderma are rarely found in direct association with each other; there are only five such reported cases, all of which were systemic scleroderma patients. Although localized and systemic scleroderma are distinct entities, autoimmunity is believed to be involved in the pathogenesis of both. Myasthenia gravis and scleroderma may occur coincidentally, but an autoimmune predisposition seems to be the more likely underlying cause, as evidenced by an increased incidence of autoantibodies and autoimmune diseases.
Pityrosporum Folliculitis: Renal Transplantation Case Report
Authors: Alves Emerson Vicente , Martins Jose Eduardo Costa , de O. Ribeiro Eliane Barbosa , Sotto Mirian N. 
Published: April 2015

AbstractPityrosporum folliculitis is caused by the fungus Pityrosporum ovale. It is characterized by the presence of pruriginous follicular papulae and papulae‐pustules in face, upper part of the trunk, and upper limb root. It is more prevailing in places with hot and humid climates. Its incidence can be associated with either immunosuppressive or chemotherapy states secondary to pathiologies. We report herewith a case of pityrosporum folliculitis in a patient who had previously underwent kidney transplantation and thes result of the itraconazol therapeutics given.
Malignant Hidroacanthoma Simplex: A Case Report
Authors: Lee Woong‐Jae , Seo Young‐Joon , Yoon Ji‐Seog , Suhr Ki‐Beom , Lee Jeung‐Hoon , Park Jang‐Kyu , Suh Kwang‐Sun 
Published: April 2015

AbstractHidroacanthoma simplex is a benign tumor of the skin originating from or showing differentiation to the sweat glands. It grossly resembles seborrheic keratosis or Bowen's disease and histologically shows intraepidermal focal growth of epithelial cells. Malignant transformation of this tumor is rare. We report a case of pigmented hidroacanthoma with malignant transformation in a 67‐year‐old woman. There was a 20‐year history of a skin lesion on the right thigh, which first appeared as a small verrucous papule, progressed to a dark‐brown colored patch, and then to a pigmented plaque. Histologically, the primary tumor was composed of small squamoid cells with marked cellular atypia. Most of the tumor cells were located in the epidermis. Immunohistochemically, the cytoplasm of some tumor cells showed a positive reaction for epithelial membrane antigen, but not for either carcino‐embryonic antigen or the S‐100 protein.
Acquired Vulvar Smooth Muscle Hamartoma: A Case Report and Review of the Literature
Authors: Kwon Kyung‐Sool , Lee Chea‐Wook , Seo Kyung‐Hyung , Park Jung‐Hum , Oh Chang‐Keun , Jang Ho‐Sun , Chung Tae‐Ahn 
Published: April 2015

AbstractA 36‐year‐old Korean woman had had a flesh‐colored, indurated plaque with pruritus on the labium majora for five years. The lesion was not found in association with hyperpigmented or hypertrichotic patches. Results of biopsy specimens showed an excess of haphazardly oriented smooth‐muscle bundles in the mid to lower dermis with an unremarkable overlying epidermis. Our diagnosis was an acquired smooth‐muscle hamartoma in the vulva. Although there have been previously reported cases of acquired smooth‐muscle hamartoma, this was the first reported case in the vulva. We also describe the characteristics differing between our case and the six previously reported ones.
Melasma in Men: A Hormonal Profile
Authors: Sialy Ravinder , Hassan Iffat , Kaur Inderjeet , Dash R.J. 
Published: April 2015

AbstractMelasma in men is much less common than in women. In the present communication, we evaluated circulating levels of LH, FSH, and testosterone in 15 men with idiopathic melasma. When compared with eleven age matched control men, the circulating LH was significantly higher and testosterone was markedly low in the melasmic men. We conclude that male melasma involves subtle testicular resistance.
Acute Infectious Urticaria: Clinical and Laboratory Analysis in Nineteen Patients
Authors: Sakurai Michiyo , Oba Misao , Matsumoto Kentaro , Tokura Yoshiki , Furukawa Fukumi , Takigawa Masahiro 
Published: April 2015

AbstractWe treated 19 Japanese patients with acute urticaria presumably caused by infection during the five years from 1994 to 1998. The patients' ages ranged from 2 to 66 years (8 males and 11 females). Most of them had urticaria, angioedema, high fever, neutrophilia, and high serum levels of C reactive protein (CRP). The skin rash lasted more than 24 hours. In four patients, a flow cytometric analysis revealed that the percentage of circulating T cells bearing T‐cell receptor Vβ3 was decreased during the active stage and that this decrease was sustained for at least 2 to 3 weeks. This suggests that certain T‐cell populations were numerically altered in association with the occurrence of the disease. A retrospective review indicated that the combination therapy with corticosteroid and antibiotics was more effective than the single use of either agent.
Conventional Cold Excision Combined with Dermabrasion for Rhinophyma
Authors: Gupta Somesh , Handa Sanjeev , Saraswat Abir , Kumar Bhushan 
Published: April 2015

AbstractA 65‐year‐old man, farmer by occupation, presented with redness and gradual enlargement of the nose. Examination revealed marked nodular enlargement of the nose and loss of normal nasal contours. Sebaceous material could be expressed from widened pores. The patient was diagnosed as rhinophyma of moderate degree. He was treated with cold knife excision combined with dermabrasion. A literature scan revealed that currently there is no evidence of superiority of much popular laser surgery over conventional cold knife surgery combined with dermabrasion for rhinophyma. Conventional surgery is time‐tested, and it does not require expensive equiment or special training.
Keratosis Lichenoides Chronica: Marked Response to Calcipotriol Ointment
Authors: Chang Sung‐Eun , Jung Eui‐Chang , Hong Seung‐Mo , Choi Jee‐Ho , Sung Kyung‐Jeh , Moon Kee‐Chan , Koh Jai‐Kyoung 
Published: April 2015

AbstractKeratosis lichenoides chronica (KCL) is a rare dermatosis characterized by a distinctive seborrheic dermatitis‐like facial eruption, together with violaceous, papular, and nodular lesions on the extremities and trunk, typically arranged in a linear and reticulate pattern. KLC is resistant to therapy, although spontaneous remission has been reported. We describe a 35‐year‐old woman with KLC who had the typical features of widespread violaceous, reticulate, and striae‐like erutpions with a prominent keratotic component over a nine‐year period and who responded well to treatment with calcipotriol ointment. The immunohistochemical profiles are presented in addition to typical histopathologic features.
Correlation between Deposition of Immuno‐Components and Infiltration Pattern of Polymorphonuclear Leukocytes in the Lesions of Chronic Urticaria
Authors: Sugita Yasushi , Morita Eishin , Kawamoto Hiroaki , Horiuchi Kenji , Yamada Satoru , Koro Osamu , Yamamoto Shoso 
Published: April 2015

AbstractUrticaria is often associated with perivascular infiltration of leukocytes into the lesions. Although mast cell‐derived chemical mediators are considered to play crucial roles in the infiltration of leukocytes as well as in the dermal edema, other mechanisms for the leukocyte infiltration have not been well defined. This study revealed that approximately 25% of the cases of chronic idiopathic urticaria in whom wheals had continued for more than 12h had deposition of immuno‐components in the lesions, although histological examination of the lesions did not show leukocytoclastic vasculitis. In these lesions with deposition of immuno‐components, both neutrophils and eosinophils had infiltrated at a constant ratio (approximately 2:1), whereas, in the lesions without deposition, a variable population of leukocytes was seen. This result suggests that activation of complements occurs in the lesions of a considerable percentage of patients with chronic idiopathic urticaria and that the complement fragments influence the infiltration patterns of polymorphonuclear leukocytes.
Post‐Scabetic Nodules: A Lymphohistiocytic Reaction Rich in Indeterminate Cells
Authors: Hashimoto Ken , Fujiwara Keiko , Punwaney Juanita , DiGregorio Fiorino , Bostrom Paul , El‐Hoshy Khaled , Aronson Peter J. , Schoenfeld Robert J. 
Published: April 2015

AbstractWe studied six infants and two adult cases of nodular scabies with immunostains and electron microscopy. All eight cases have had either direct (KOH) or family histories of scabies and were treated with lindane 1% cream or permethrin 5% cream. Family members responded very well, but our patients developed multiple papulo‐nodular lesions which were initially very pruritic and, in some cases, persisted from several months to over one year. H & E stain of biopsied tissue sections revealed a heavy perivascular and periappendageal lymphohistiocytic cell infiltration. Immunophenotype of these cells was compatible with Langerhans cells, i.e. CD1A (+), S‐100 (+) and HLA‐DR (+). Electron microscopy showed that these histiocytic cells satisfied all the ultrastructural criteria of Langerhans cells except for the absence of Birbeck's granules. Lag, a monoclonal antibody for Birbeck's granules, was negative. “Persistent nodules in scabies” or “nodular scabies” seems to represent a prolonged response of indeterminate cells‐lymphocytes to mite antigens.
Eosinophilic Pustular Folliculitis: Report of Seven Cases in Thailand
Authors: Rattana‐Apiromyakij Niramol , Kullavanijaya Preya 
Published: April 2015

AbstractSeven cases of eosinophilic pustular folliculitis (EPF) were diagnosed at the Institute of Dermatology within the seven years from 1989–1996. There were 4 males and 3 females, age 24–44 years, with durations of the disease before diagnosis ranging from 3 months to 5 years. The face was the most commonly involved area. Lesions also occured simultaneously on other sites including the chest, trunk, scalp, and palmoplantar areas. Diagnosis was made from clinical features, hematologic examinations, and histopathologic pictures. Topical piroxicam gel, 0.5%, and oral indomethacin gave good results; some lesions subsided within a few days, and the remissions lasted for four months to five years.