bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Impact of Using Mobile-Enabled Devices on Patient Engagement in Remote Monitoring Programs
Authors: Agboola Stephen , Havasy Rob , Myint-U Khinlei , Kvedar Joseph , Jethwani Kamal 
Published: January 2014

Background: Different types of data transmission technologies are used in remote monitoring (RM) programs. This study reports on a retrospective analysis of how participants engage, based on the type of data transfer technology used in a blood pressure (BP) RM program, and its potential impact on RM program design and outcomes. Methods: Thirty patients, aged 23–84 years (62 ± 14 years), who had completed at least 2 months in the program and were not participating in any other clinical trial were identified from the Remote Monitoring Data Repository. Half of these patients used wireless-based data transfer devices [wireless-based device (WBD)] while the other half used telephone modem-based data transfer devices [modem-based device (MBD)]. Participants were matched by practice and age. Engagement indices, which include frequency of BP measurements, frequency of data uploads, time to first BP measurement, and time to first data upload, were compared in both groups using the Wilcoxon-Mann-Whitney two-sample rank-sum test. Help desk call data were analyzed by Chi square test. Results: The frequency of BP measurements and data uploads was significantly higher in the WBD group versus the MBD group [median = 0.66 versus 0.2 measurements/day ( p = .01) and 0.46 versus 0.01 uploads/day ( p < .001), respectively]. Time to first upload was significantly lower in the WBD group (median = 4 versus 7 days; p = .02), but time to first BP measurement did not differ between the two groups (median = 2 versus 1 day; p = .98). Conclusion: Wireless transmission ensures instantaneous transmission of readings, providing clinicians timely data to intervene on. Our findings suggest that mobile-enabled wireless technologies can positively impact patient engagement, outcomes, and operational workflow in RM programs.
Understanding the evolutionary structural variability and target specificity of tick salivary Kunitz peptides using next generation transcriptome data
Authors: Schwarz Alexandra , Cabezas-Cruz Alejandro , Kopecký Jan , Valdés James J 
Published: January 2014

Abstract

Background
Ticks are blood-sucking arthropods and a primary function of tick salivary proteins is to counteract the host’s immune response. Tick salivary Kunitz-domain proteins perform multiple functions within the feeding lesion and have been classified as venoms; thereby, constituting them as one of the important elements in the arms race with the host. The two main mechanisms advocated to explain the functional heterogeneity of tick salivary Kunitz-domain proteins are gene sharing and gene duplication. Both do not, however, elucidate the evolution of the Kunitz family in ticks from a structural dynamic point of view. The Red Queen hypothesis offers a fruitful theoretical framework to give a dynamic explanation for host-parasite interactions. Using the recent salivary gland Ixodes ricinus transcriptome we analyze, for the first time, single Kunitz-domain encoding transcripts by means of computational, structural bioinformatics and phylogenetic approaches to improve our understanding of the structural evolution of this important multigenic protein family.

Results
Organizing the I. ricinus single Kunitz-domain peptides based on their cysteine motif allowed us to specify a putative target and to relate this target specificity to Illumina transcript reads during tick feeding. We observe that several of these Kunitz peptide groups vary in their translated amino acid sequence, secondary structure, antigenicity, and intrinsic disorder, and that the majority of these groups are subject to a purifying (negative) selection. We finalize by describing the evolution and emergence of these Kunitz peptides. The overall interpretation of our analyses discloses a rapidly emerging Kunitz group with a distinct disulfide bond pattern from the I. ricinus salivary gland transcriptome.

Conclusions
We propose a model to explain the structural and functional evolution of tick salivary Kunitz peptides that we call target-oriented evolution. Our study reveals that combining analytical approaches (transcriptomes, computational, bioinformatics and phylogenetics) improves our understanding of the biological functions of important salivary gland mediators during tick feeding.
The eleventh reported case of Mulvihill-Smith syndrome in the literature
Authors: Breinis Paulo , Alves Flavio Geraldes , Alves Camila AE , Cintra Rafael G , Almeida Débora , Passarelli Priscila C , Domingues Camila , Gerbim Talita , Gasparetto Régia , de Abreu Luiz Carlos , Valenti Vitor E , de Oliveira Adriana Gonçalves , de Mello Monteiro Carlos Bandeira , Wajnzstejn Rubens 
Published: January 2014

Abstract

Background
The Mulvihill-Smith Syndrome was first recognized in 1975. After the recognition of the Mulvihill-Smith Syndrome, ten cases have been described.

Case presentation
This article describes the eleventh case of this syndrome in a male patient, 24 years-old with short stature and microcephaly with mild cognitive impairment, deafness and allergic conjunctivitis. The patient was hospitalized several times for repeated infections, and the presence of multiple melanocytic nevi on his skin was noticed.

Conclusions
Based on the entire set of signs and symptoms presented in our study, it was diagnosed the patient with Mulvihill-Smith Syndrome.
Interventions to decrease skin cancer risk in outdoor workers: update to a 2007 systematic review
Authors: Horsham Caitlin , Auster Josephine , Sendall Marguerite C , Stoneham Melissa , Youl Philippa , Crane Phil , Tenkate Thomas , Janda Monika , Kimlin Michael 
Published: January 2014

Abstract

Background
Outdoor workers are at high risk of harmful ultraviolet radiation exposure and are identified as an at risk group for the development of skin cancer. This systematic evidence based review provides an update to a previous review published in 2007 about interventions for the prevention of skin cancer in outdoor workers.

Results
This review includes interventions published between 2007-2012 and presents findings about sun protection behaviours and/or objective measures of skin cancer risk. Six papers met inclusion criteria and were included in the review. Large studies with extended follow-up times demonstrated the efficacy of educational and multi-component interventions to increase sun protection, with some higher use of personal protective equipment such as sunscreen. However, there is less evidence for the effectiveness of policy or specific intervention components.

Conclusions
Further research aimed at improving overall attitudes towards sun protection in outdoor workers is needed to provide an overarching framework.
Low dose aspirin and low-molecular-weight heparin in the treatment of pregnant Libyan women with recurrent miscarriage
Authors: Elmahashi Mohamed O , Elbareg Aisha M , Essadi Fathi M , Ashur Bashur M , Adam Ishag 
Published: January 2014

Abstract

Background
Recurrent miscarriage is a major women’s health problem. Aspirin and heparin have been shown to have potentially beneficial effects on trophoblast implantation. However, few published data on this issue are available from developing countries.

Methods
An open clinical trial was conducted at the Department of Obstetrics and Gynecology at Misurata Teaching Hospital in Libya from January 2009 to December 2010 to investigate the effects of treatment with low dose aspirin (LDA) versus treatment with low-molecular-weight-heparin (LMWH) in combination with LDA on patients with a history of recurrent miscarriages. A total of 150 women were enrolled in the study. Women were eligible for the study if they had a history of three or more consecutive miscarriages. Participants were randomly assigned to receive either LDA (75 mg daily) alone or a combination of LDA and LMWH (75 women per treatment group). The primary outcomes were the rate of miscarriages and live births for each group.

Results
Compared with the group who received LDA alone, the combination group had a significantly lower number of miscarriages (22/75 [29%] vs. 43/75 [47%], P < 0.001) and had a significantly higher number of live births (53/75 [71%] vs. 32/75 [42%], P < 0.001). Two preterm infants in the LDA group and three in the combination group were admitted to the neonatal intensive care unit. There were no significant differences in the mean (SD) birth weights of neonates born in either group (2955.4 ± 560 vs. 3050 ± 540 g for the LDA and combination groups, respectively, P = 0.444). There were no congenital abnormalities detected in either group.

Conclusion
The combination of LDA and LMWH is better than LDA alone for the maintenance of pregnancy in patients with recurrent first trimester miscarriage.

Trial registration

NCT01917799
Tumour angiogenesis in Epstein-Barr virus-associated post-transplant smooth muscle tumours
Authors: Jonigk Danny , Izykowski Nicole , Maegel Lavinia , Schormann Eileen , Ludewig Britta , Kreipe Hans , Hussein Kais 
Published: January 2014

Abstract
Epstein-Barr virus (EBV)-associated post-transplant smooth muscle tumours (PTSMT), are rare complications following organ/stem cell transplantation. Despite the mainly benign behaviour of PTSMT, alternative therapies are needed for those patients with progressive tumours. In tumours not approachable by surgery or reduction of immunosuppression, the angiogenic microenvironment might be a potential target of therapy, an approach that is well utilised in other soft tissue neoplasms. In a previous study, we evaluated the expression of EBV-related genes and the microRNA profile in PTSMT, but so far the characteristics of angiogenesis in PTSMT are not known. Therefore, the aim of this study was to evaluate the expression pattern of angiogenesis-related genes in PTSMT, in order to identify potential target molecules for anti-angiogenic therapy.
PTSMT (n = 5 tumours) were compared with uterine leiomyomas (n = 7). Analyses included real-time PCR of 45 angiogenesis-associated genes, immunohistochemistry (CD31, prostaglandin endoperoxide synthase 1/PTGS1) and assessment of tumour vascularisation by conventional histopathology.
PTSMT showed similar or fewer vessels than leiomyomas. Of the genes under investigation, 23 were down-deregulated (pro-angiogenic and some anti-angiogenic factors) and five were up-regulated (e.g. PTGS1 which is expressed at very low levels in leiomyomas but moderately higher levels in PTSMT).
In summary, no particular target molecule could be identified, because tumour angiogenesis in PTSMT is characterised by low levels of major pro-angiogenic factors and there is no prominent increase in tumour vascularisation. EBV can induce angiogenesis via its viral late membrane protein 1 (LMP1) but PTSMT frequently do not express LMP1, which could be an explanation why, despite EBV infection, PTSMT show no exaggerated tumour angiogenesis.
Removal of heavy metals from aqueous solution using platinum nanopartcles/Zeolite-4A
Authors: Mehdizadeh Sofia , Sadjadi Sodeh , Ahmadi Seyed Javad , Outokesh Mohammad 
Published: January 2014

Abstract
The effects of varying operating conditions on metals removal from aqueous solution using a novel platinum nanopartcles/Zeolite-4A adsorbent are reported in this paper. Characterization of the adsorbent showed successful production of platinum nanopartcles on Zeolite-4A using 3 Wt% platinum. The effects of operation conditions on metals removal using this adsorbent were investigated. The optimal metals adsorption was observed at pH 7, 0.1 g/10 mL dosage and 30 min contact time. Sorption data have been interpreted in terms of Langmuir and Freundlich isotherms.
Dust storm simulation over Iran using HYSPLIT
Authors: Ashrafi Khosro , Shafiepour-Motlagh Majid , Aslemand Alireza , Ghader Sarmad 
Published: January 2014

Abstract
Particulate matters have detrimental effects on human health, environment and economic. This pollutant may emit from anthropogenic or natural sources. On global scale, main proportion of natural particulate matter release to the atmosphere because of wind erosion from arid and semi-arid regions. Recently, the amount of dust coming from Arabian countries has dramatically increased, especially dust storms that are affecting western and even central parts of Iran. This phenomenon has caused a lot of environmental problems. Dust source identification and trajectory simulation using numerical techniques are the main aims of this study. HYSPLIT (Hybrid Single Particle Lagrangian Integrated Trajectory) model dust module and trajectory simulation are utilized in this research and two case studies are investigated (in May and June 2010). The base of the HYSPLIT dust module is the PM10 dust storm emission algorithm for desert land use. This methodology is applied to estimate hotspots and trajectories. Due to the results, dust storms started on May 17th and June 7th because of high wind shear (>8.5 m/s) from the western Syrian Desert. The source region limited to 32.50 °N to 33.80 °N and 38.00 °E to 38.80 °E coordinates. Dust plumes lifted and dispersed towards the east and southeast of the sources and reached Ahvaz on May 18th and June 8th. The average of PM10 concentration in these dates reached 625 and 494

μg

m
3

on Ahvaz monitoring stations, respectively. Moreover, the results gained from the model for dust motion simulation are similar to the MODIS satellite images.
Metrological Ensuring of Laser Safety
Authors: Рахманов  , Rakhmanov Boris , Кибовский  , Kibovskiy V. 
Published: January 2014

Questions of historical development and current state in the area of metrological support related to laser safety system in
Russia have been considered. A review of main metrological normative documents in the area of laser dosimetry has been
performed. Technical characteristics of modern laser dosimeters have been presented. A need of development of new perspective
methods related to laser dosimetry on open spaces has been shown.
Problems of safety and standard ensuring control of vector dynamic parameters of objects of a technosphere
Authors: Хлыстунов  , Khlystunov Mikhail , Подувальцев  , Poduvaltsev V. , Могилюк  , Mogilyuk Zhanna 
Published: January 2014

Metrological problems related to normative and mathematical support of technosphere objects’ safety vector dynamic parameters
spatial control are considered in this paper. On the example of analysis of regulatory documents regulating dynamic surveys,
the absence evidence in these documents of necessary and sufficient criteria for practical realization of safety problems have
been presented. On the basis of results related to dynamic surveys of technosphere’s real objects it has been shown that existing
regulatory approach doesn´t allow to identify controlled forms of vibrations of buildings and constructions.
Application of Vortex Technology for Purification of Vinyl Chloride Production Waste
Authors: Девисилов  , Devisilov Vladimir , Жидков  , Zhidkov Dmitriy 
Published: January 2014

The settlement assessment of Ranque—Hilsch vortex pipes application for low-temperature purification of vinyl chloride
production waste gases has been presented. It is shown that implementation of the recuperative scheme with vortex pipes will
allow to improve ecological and economic indicators of the main chemical technology. Bench tests of vortex generators of cold
as a part of the industrial unit gave the chance to receive their thermodynamic characteristics on real waste gas and technical
nitrogen. It is established that in lack of the recuperative heat exchanger a condensation of vinyl chloride vapors proceeds in
vortex pipe itself. Application of a three-line vortex pipe is recommended in case of need. At research of not adiabatic vortex pipe
cooled by a coolant, it has been established an experiment divergence with the theory of micro refrigerating cycles. It is offered
to explain the arisen contradiction from a position of shock and wave mechanism of Ranque—Hilsch effect developed by authors.
Russian Industry and Industrial Dangers in Transition Period. Accident Rate and Traumatism of Deindustrialization
Authors: Гражданкин  , Grazhdankin Aleksandr , Пуликовский  , Pulikovskiy K. 
Published: January 2014

The solution of industrial safety problems in new Russia is substituted for formation of danger without industry – an unprecedented
phenomenon for the large industrial country. Reformers are beginning to measure inability of new business to execute &#34;backward&#34;
safety standards by rubles of &#34;excess investments&#34;, trampling on freedom of economic efficiency. Monetization apologists calculate
rising accidents danger as miserly micro shares of risk (10-6). Businessmen began to look at industrial production as at risky
game on retreat and even on refusal from &#34;written down by blood&#34; existing industrial safety requirements. For this purpose it has
become necessary to build urgently a new pseudo science – theory and practice of &#34;risk management&#34; – well-known abroad social
and engineering technology on kindling or pacification of inhabitants’ technophobia. In this imitating program virtual &#34;risk&#34; has
become &#34;noble cause&#34; of deindustrialization of Russia. Planning of Russia’s safe enter on new industrial rails is urgently requiring
a map development of real dangers of major industrial accidents. Available numerous schemes of &#34;risk management&#34; don´t suit for
development of crucial decisions on industrial safety ensuring in modern Russian conditions.
Generation Changes of Polish Adolescents Self-Image (cohorts 1987 versus 2001)
Authors: Modrzejewska Renata , Badura-Madej Wanda 
Published: January 2014

Aim of the studyTo compare the self-image of adolescents over fifteen years in Poland (1987 versus 2001).Subject or material and methodsParticipants were 1872 school students aged 16 to 17 years randomly selected from high school in Kraków (university town). Self-image was measured by the Offer Self-Image Questionnaire. MANOVA, ANOVAs and CFA were applied as statistical methods.ResultsBetween 1987 and 2001 self-image changes toward a more positive self perceptions in 2001. Boys described themselves better on most scales. Girls score better on vocational and educational goals and superior adjustment.DiscussionBased on the results of population studies on adolescents’ self-image, it can be claimed that within nearly 15 years, 17-year-olds’ self-image improved. Thus, the hypothesis was confirmed that adolescents’ self-image in subsequent birth cohorts had changed. A similar conclusion had been drawn by Offer in studies quoted earlier.ConclusionsSelf-image changes over time. It is influenced by macrosocial conditions. The research confirm 5-factor model of self-image structure of the questionnaire and its inter-generational and inter-cultural stability.
The ecological approach of J. J. Gibson
Authors: MacDougall Robert C. 
Published: January 2014

Abstract
The affordance concept became a core feature of psychologist J. J. Gibson’s later work informing his ‘ecological approach’ to perception. Affordance refers to the practical properties of objects or artefacts; how these properties illuminate the many different possibilities and prohibitions for thought and action that emerge in that altered context. The aim of this article is to detail how and where Gibson’s thinking aligns with, qualifies, and extends the general methodological approach of media ecology, with a special focus on his affordance concept as an analogue to Marshall McLuhan’s technological extension or prosthesis idea. With a soft kind of determinism operating in the background, the affordance and extension can work synergistically to help us understand how the formal properties of some things, and the interaction of organisms and things does much to enable, limit, delimit, and even help determine what some thing or someone can do.
Binary and ternary combinations of anti-HIV protease inhibitors: effect on gene expression and functional activity of CYP3A4 and efflux transporters
Authors: Kwatra Deep , Vadlapudi Aswani Dutt , Vadlapatla Ramya Krishna , Khurana Varun , Pal Dhananjay , Mitra Ashim K. 
Published: January 2014

Abstract

Background: The purpose of this study is to identify the effect of binary and ternary combinations of anti-HIV protease inhibitors (PIs) on the expression of metabolizing enzyme (CYP3A4) and efflux transporters [multidrug resistance-associated protein 2 (MRP2), P-glycoprotein (P-gp) and breast cancer resistant protein (BCRP)] in a model intestinal cell line (LS-180).

Methods: LS-180 cells were treated with various combinations of PIs (amprenavir, indinavir, saquinavir and lopinavir), and the mRNA expression levels of metabolizing enzyme and efflux transporters were measured using quantitative reverse transcription polymerase chain reaction. The alteration of gene expression was further correlated to the expression of nuclear hormone receptor PXR. Uptake of fluorescent and radioactive substrates was carried out to study the functional activity of these proteins. Cytotoxicity and adenosine triphosphate (ATP) assays were carried out to measure stress responses.

Results: Binary and ternary combinations of PIs appeared to modulate the expression of CYP3A4, MRP2, P-gp and BCRP in a considerable manner. Unlike the individual PIs, their binary combinations showed much greater induction of metabolizing enzyme and efflux proteins. However, such pronounced induction was not observed in the presence of ternary combinations. The observed trend of altered mRNA expression was found to correlate well with the change in expression levels of PXR. The gene expression was found to correlate with activity assays. Lack of cytotoxicity and ATP activity was observed in the treatment samples, suggesting that these alterations in expression levels were probably not stress responses.

Conclusions: In the present study, we demonstrated that combinations of drugs can have serious consequences toward the treatment of HIV infection by altering their bioavailability and disposition.
Diagnosing diagnostic failure
Authors: Weed Lawrence L. , Weed Lincoln 
Published: January 2014

AbstractDiagnostic failure results from misplaced dependence on the clinical judgments of expert physicians. The remedy for diagnostic failure involves defining standards of care for managing clinical information (medical knowledge and patient data), and implementing those standards with information tools designed for that purpose. These standards and tools are external to the minds of physicians, thus bypassing two inherent constraints on human cognition: limited capacities for information retrieval and processing, and innate heuristics and biases. Medical education and credentialing socialize physicians into misplaced acceptance of these constraints. Medical students acquire scientific knowledge, but not scientific behaviors. A scientific approach to diagnosis begins with using information tools to identify all diagnostic possibilities for the presenting problem and the initial findings needed to determine which possibilities are worth investigating in the patient. If the initial findings do not reveal a clear diagnostic solution, then information tools must be employed as part of a system of care to enforce highly organized follow-up processes, that is, careful problem definition, planning, execution, feedback, and corrective action over time, all documented under strict standards of care for managing the complexities involved.