bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Differential Reactivity of Fluorinated Homopropargylic Amino Esters vs Gold(I) Salts. The Role of the Nitrogen Protecting Group.
Authors: Sanchez‐Rosello Maria , Miro Javier , del Pozo Carlos , Fustero Santos 
Published: June 2015

AbstractThe gold(I)‐catalyzed hydroarylation/isomerization reaction of N‐protected homopropargyl amino esters (III) gives quinoline derivatives of type (IV).
ChemInform Abstract: Chemoselective Deprotection and Deprotection with Concomitant Reduction of 1,3‐Dioxolanes, Acetals and Ketals Using Nickel Boride.
Authors: Khurana Jitender M. , Dawra Kiran , Sharma Purnima 
Published: June 2015

AbstractThe deprotection of acetals and ketals using in situ generated nickel boride is described.
ChemInform Abstract: Catalytic Asymmetric Henry Reaction of Nitroalkanes and Aldehydes Catalyzed by a Chiral N,N′‐Dioxide/Cu(I) Complex.
Authors: Mei Hongjiang , Xiao Xiao , Zhao Xiaohu , Fang Bing , Liu Xiaohua , Lin Lili , Feng Xiaoming 
Published: June 2015

AbstractThe asymmetric nitroaldol reaction of nitroethane with aromatic, heteroaromatic, or α,β‐unsaturated aldehydes gives the anti‐β‐nitroalcohols as main isomers.
ChemInform Abstract: A Novel Aromatic Carbocation‐Based Coupling Reagent for Esterification and Amidation Reactions.
Authors: Nguyen Thanh V. , Lyons Demelza J. M. 
Published: June 2015

AbstractChlorotropylium chloride is successfully applied as a novel coupling reagent for the two‐step esterification and amidation reactions of different carboxylic acids.
ChemInform Abstract: Cleavage of C—N Bonds in Guanidine Derivatives and Its Relevance to Efficient C—N Bonds Formation.
Authors: Chang Denghu , Zhu Dan , Zou Peng , Shi Lei 
Published: June 2015

AbstractDiarylguanidines are converted to amides by copper(II)‐salts in the presence of palladium acetate.
ChemInform Abstract: Variations in the Blaise Reaction: Conceptually New Synthesis of 3‐Amino Enones and 1,3‐Diketones.
Authors: Rao H. Surya Prakash , Muthanna Nandurka 
Published: June 2015

AbstractThe coupling reactions of 2‐bromoketones with nitriles results in the formation of 3‐amino enones or 1,3‐diketones depending on the hydrolysis conditions.
ChemInform Abstract: Pd‐Catalyzed Monoselective ortho‐C—H Alkylation of N‐Quinolyl Benzamides: Evidence for Stereoretentive Coupling of Secondary Alkyl Iodides.
Authors: Zhang Shu‐Yu , Li Qiong , He Gang , Nack William A. , Chen Gong 
Published: June 2015

AbstractA method for the monoselective alkylation of ortho‐C—H bonds of N‐quinolyl benzamides with both primary and secondary alkyl halides under palladium catalysis is reported.
ChemInform Abstract: A Phosphetane Catalyzes Deoxygenative Condensation of α‐Keto Esters and Carboxylic Acids via PIII/PV=O Redox Cycling.
Authors: Zhao Wei , Yan Patrick K. , Radosevich Alexander T. 
Published: June 2015

AbstractReduction of the P‐oxide APO with PhSiH3 affords a tricoordinate aminophosphetane which promotes the title reaction to produce α‐acyloxy esters with a high functional group compatibility.
ChemInform Abstract: Nickel‐Catalyzed and Benzoic Acid‐Promoted Direct Sulfenylation of Unactivated Arenes.
Authors: Yang Ke , Wang Yuqi , Chen Xinyong , Kadi Adnan A. , Fun Hoong‐Kun , Sun Hao , Zhang Yan , Lu Hongjian 
Published: June 2015

AbstractDepending on substitution pattern, N‐(2‐(pyridin‐2‐yl)propan‐2‐yl)arylamides are regioselectively mono‐ and/or bis‐arylsulfenylated with diaryl disulfides (II) and (IX) in the ortho‐position(s) next to the amide group.
ChemInform Abstract: Pd(II)‐Catalyzed Allylic C—H Amination for the Preparation of 1,2‐ and 1,3‐Cyclic Ureas.
Authors: Nishikawa Yasuhiro , Kimura Seikou , Kato Yuri , Yamazaki Natsuka , Hara Osamu 
Published: June 2015

AbstractA general procedure for the synthesis of the title compounds by intramolecular allylic C—H amination is developed.
ChemInform Abstract: Synthesis of Adamantyl Substituted 1,2,3‐Triazol‐5‐ylidene Ligands and Their PEPPSI‐Type Palladium Complexes.
Authors: Mitsui Takashi , Sugihara Masato , Tokoro Yuichiro , Fukuzawa Shin‐ichi 
Published: June 2015

AbstractThe synthesized catalysts are applied in Hiyama and Suzuki‐Miyaura couplings providing biaryls in good to excellent yields.
ChemInform Abstract: Aminocatalytic Cross‐Coupling Approach via Iminium Ions to Different C—C Bonds.
Authors: Mupparapu Nagaraju , Battini Narsaiah , Battula Satyanarayana , Khan Shahnawaz , Vishwakarma Ram A. , Ahmed Qazi Naveed 
Published: June 2015

AbstractThe pyrrolidine‐catalyzed aerobic cross‐coupling of glyoxals (I) with phenols, naphthols, indoles, and pyrroles as nucleophiles leads to diones (III) [42 examples].
ChemInform Abstract: Cyclopropanation Using Flow‐Generated Diazo Compounds.
Authors: Roda Nuria M. , Tran Duc N. , Battilocchio Claudio , Labes Ricardo , Ingham Richard J. , Hawkins Joel M. , Ley Steven V. 
Published: June 2015

AbstractA method for the cyclopropanation of electron‐poor olefins using unstabilized diazo compounds generated under continuous flow conditions and room temperature is developed.
ChemInform Abstract: Stereoselective Synthesis of Highly Functionalized Indanes and Dibenzocycloheptadienes Through Complex Radical Cascade Reactions.
Authors: Kong Wangqing , Fuentes Noelia , Garcia‐Dominguez Andres , Merino Estibaliz , Nevado Cristina 
Published: June 2015

AbstractTwo highly stereoselective radical‐mediated syntheses of densely functionalized indanes and dibenzocycloheptadienes from ortho‐vinyl‐ and ortho‐vinylaryl‐substituted N‐(arylsulfonyl)‐acrylamides, respectively, are presented.
ChemInform Abstract: Synthesis of the First Completely Spin‐Compatible N@C60 Cyclopropane Derivatives by Carefully Tuning the DBU Base Catalyst.
Authors: Zhou Shen , Rasovic Ilija , Briggs G. Andrew D. , Porfyrakis Kyriakos 
Published: June 2015

AbstractTwo cyclopropane derivatives of N@C60 are synthesized by well‐controlled Bingel reactions, in which 94% of the spin centres are retained, as confirmed by a series of quantitative electron spin paramagnetic resonance measurements.
ChemInform Abstract: The Enantioselective Construction of Tetracyclic Diterpene Skeletons with Friedel—Crafts Alkylation and Palladium‐Catalyzed Cycloalkenylation Reactions.
Authors: Burke Sarah J. , Malachowski William P. , Mehta Sharan K. , Appenteng Roselyn 
Published: June 2015

AbstractTricarbocyclic products (II) are obtained by an extension of the enantioselective Birch‐Cope sequence with Friedel‐Crafts alkylation reactions.
ChemInform Abstract: Direct Generation of Oxygen‐Stabilized Radicals by H· Transfer from Transition Metal Hydrides.
Authors: Kuo Jonathan L. , Hartung John , Han Arthur , Norton Jack R. 
Published: June 2015

AbstractThe transition‐metal hydride HV(CO)4dppe containing a weak M—H bond is applied to convert enol ethers to α‐alkoxy radicals, which undergo cyclizations with high diastereoselectivities.
ChemInform Abstract: Nickel—NHC‐Catalyzed Cross‐Coupling of 2‐Methylsulfanylbenzofurans with Alkyl Grignard Reagents.
Authors: Baralle Alexandre , Otsuka Shinya , Guerin Vincent , Murakami Kei , Yorimitsu Hideki , Osuka Atsuhiro 
Published: June 2015

AbstractThe efficient method is applied in the synthesis of protein tyrosine phosphatase inhibitors of type (VI).
ChemInform Abstract: Copper‐Catalyzed Asymmetric Oxidative Cross‐Coupling of 2‐Naphthols with Aryl Methyl Ketones.
Authors: Deng Tao , Wang Hongjun , Cai Chun 
Published: June 2015

AbstractThe facile protocol uses the oxygen in air as the oxidant and gives enantioenriched naphthofuranones with up to 87% ee.
ChemInform Abstract: Domino [4 + 1]‐Annulation of α,β‐Unsaturated δ‐Amino Esters with Rh(II)—Carbenoids — A New Approach Towards Multi‐Functionalized N‐Aryl Pyrrolidines.
Authors: Medvedev J. J. , Galkina O. S. , Klinkova A. A. , Giera D. S. , Hennig L. , Schneider C. , Nikolaev V. A. 
Published: June 2015

AbstractMulti‐functionalized pyrrolidines are obtained by catalytic decomposition of diazomalonates and other diazoesters using Rh(II)‐complexes in the presence of α,β‐unsaturate δ‐(N‐aryl)aminoesters.
ChemInform Abstract: Chiral Broensted Acid Catalyzed Intermolecular Friedel—Crafts Alkylation of Styrenes with Indoles: Construction of All‐Carbon Quaternary Stereocenters.
Authors: Li Ming‐Li , Chen Dian‐Feng , Luo Shi‐Wei , Wu Xiang 
Published: June 2015

AbstractA breakthrough in asymmetric Friedel‐Crafts reactions is achieved by using terminal 1,1‐diarylalkenes as alkylating reagents, which avoids the generation of side products.
ChemInform Abstract: Copper‐Catalyzed Synthesis of N‐Aryl and N‐Sulfonyl Indoles from 2‐Vinylanilines with O2 as Terminal Oxidant and TEMPO as Cocatalyst.
Authors: Liwosz Timothy W. , Chemler Sherry R. 
Published: June 2015

AbstractWhereas N‐aryl and N‐sulfonyl 2‐vinyl aniline derivatives form the desired products in moderate to high yields, primary and N‐alkyl 2‐vinyl aniline analogues are unreactive.
ChemInform Abstract: Multi‐Site Cyclization via Initial C—H Activation Using a Rhodium(III) Catalyst: Rapid Assembly of Frameworks Containing Indoles and Indolines.
Authors: Huang Ji‐Rong , Qin Liu , Zhu Yu‐Qin , Song Qiang , Dong Lin 
Published: June 2015

AbstractThe Rh‐catalyzed cyclization of indolinones (I) with symmetrical alkynes (II) leads to pseudo‐indoxyls (III) in moderate to high yields.
ChemInform Abstract: Facile Synthesis of 11‐Aryl‐6H‐isoindolo[2,1‐a]indol‐6‐ones via Hypervalent Iodine(III)‐Promoted Cascade Cyclization.
Authors: Dev Kapil , Maurya Rakesh 
Published: June 2015

AbstractThe title tetracyclic ring systems are efficiently obtained by regio‐ and chemoselective intramolecular cascade oxidative cyclization of various 2‐(1‐arylethynyl)benzamides under metal‐free reaction conditions.
ChemInform Abstract: Copper(II)‐Catalyzed Enantioselective Intramolecular Cyclization of N‐Alkenylureas.
Authors: Fu Shaomin , Yang Honghao , Li Guoqiang , Deng Yuanfu , Jiang Huanfeng , Zeng Wei 
Published: June 2015

AbstractThe first example of Cu(II)‐catalyzed asymmetric intramolecular cyclization of N‐alkenylureas is developed which provides a useful method for the rapid assembly of chiral vicinal diamino bicyclic heterocycles in good yields and high enantioselectivity.
ChemInform Abstract: Enantioselective Addition of Oxazolones to N‐Protected Imines Catalyzed by Chiral Thioureas.
Authors: Zabka Matej , Malastova Andrea , Sebesta Radovan 
Published: June 2015

AbstractThe hydrogen bond catalyzed aza‐Mannich addition of oxazolones to a wide range of protected aldimines using bifunctional thiourea catalysts is presented.
ChemInform Abstract: Large‐Scale Continuous Flow Transformation of Oximes into Fused‐Bicyclic Isoxazolidines: An Example of Process Intensification.
Authors: Rincon Juan A. , Mateos Carlos , Garcia‐Losada Pablo , Mergott Dustin J. 
Published: June 2015

AbstractBicyclic isoxazolidines are efficiently obtained by a continuous flow protocol via [3+2] cycloaddition of in situ formed nitrones obtained from oximes.
ChemInform Abstract: A New Multicomponent Reaction: Unexpected Formation of Derivatizable Cyclic α‐Alkoxy Isothioureas.
Authors: Brockmeyer Fabian , Morosow Valentin , Martens Juergen 
Published: June 2015

AbstractThe reaction of thiazoline S‐monoxides with isonitriles gives cyclic α‐alkoxy isothioureas.
ChemInform Abstract: Microwave Synthesis of 5‐Substituted 1H‐Tetrazoles Catalyzed by Bismuth Chloride in Water.
Authors: Coca Adiel , Feinn Liana , Dudley Joshua 
Published: June 2015

AbstractBismuth chloride is shown to be an effective catalyst for the [2+3] cycloaddition between various nitriles (aromatic, aliphatic, vinyl) and sodium azide under microwave irradiation and optimized reaction conditions.
ChemInform Abstract: Secondary Amine Based Ionic Liquid: An Efficient Catalyst for Solvent Free One Pot Synthesis of Xanthenes and Benzoxanthenes.
Authors: Das Pranab J. , Das Jupitara 
Published: June 2015

AbstractAmong three ionic liquids tested, propylammoniumhydrogensulfate is found to be the most efficient promoter for the synthesis of title compounds (III), (V), and (VI).
ChemInform Abstract: 3,5‐Disubstituted 2‐Aminopyridines via Nickel‐Catalyzed Cycloaddition of Terminal Alkynes and Cyanamides.
Authors: Zhong Yao , Spahn Nathan A. , Stolley Ryan M. , Nguyen Minh H. , Louie Janis 
Published: June 2015

AbstractIn addition to 3,5‐disubstituted 2‐aminopyridines the 4,6‐substituted isomers are isolated in trace to significant amounts.
ChemInform Abstract: Aza‐Annulation of Enynyl Azides: A New Approach to Substituted Pyridines.
Authors: Raji Reddy Chada , Panda Sujatarani A. , Reddy Motatipally Damoder 
Published: June 2015

AbstractA novel aza‐annulation of 2‐en‐4‐ynyl azides, derived from MBH‐acetates of acetylenic aldehydes, to synthesized substituted pyridines is developed.
ChemInform Abstract: Synthesis of Heteroarylogous 1H‐Indole‐3‐carboxamidines via a Three‐Component Interrupted Ugi Reaction.
Authors: La Spisa Fabio , Meneghetti Fiorella , Pozzi Beatrice , Tron Gian Cesare 
Published: June 2015

AbstractThe novel one‐pot multicomponent reaction is based on the reaction of N‐alkyl‐N‐(1H‐indol‐2‐ylmethyl)amines, with various carbonyl compounds, such as aldehydes including formaldehyde or cyclohexenone, and variously functionalized isocyanides.
ChemInform Abstract: Silver Catalyzed Decarboxylative Alkylation and Acylation of Pyrimidines in Aqueous Media.
Authors: Mai Wen‐Peng , Sun Bin , You Li‐Qin , Yang Liang‐Ru , Mao Pu , Yuan Jin‐Wei , Xiao Yong‐Mei , Qu Ling‐Bo 
Published: June 2015

Abstract4‐Alkylated pyrimidines or acylated pyrimidines are efficiently obtained using aliphatic carboxylic acids or 2‐oxocarboxylic acids as substrates and silver salt as catalyst under mild conditions.
ChemInform Abstract: An “All‐Water” Strategy for Regiocontrolled Synthesis of 2‐Aryl Quinoxalines.
Authors: Tanwar Babita , Purohit Priyank , Raju Banothu Naga , Kumar Dinesh , Kommi Damodara N. , Chakraborti Asit K. 
Published: June 2015

AbstractOptimum reaction conditions for the one‐pot two‐step synthesis of 2‐aryl quinoxalines in aqueous medium are studied.
ChemInform Abstract: Copper‐Catalyzed Ring Expansion of 2‐Aminobenzothiazoles with Alkynyl Carboxylic Acids to 1,4‐Benzothiazines.
Authors: Qiu Jing‐Wen , Hu Bo‐Lun , Zhang Xing‐Guo , Tang Ri‐Yuan , Zhong Ping , Li Jin‐Heng 
Published: June 2015

AbstractA one‐pot synthesis of the title compounds (III) is presented via decarboxylative coupling, nucleophilic ring‐opening reaction, and an intramolecular hydroamination process.
ChemInform Abstract: Nucleophile‐Dependent Diastereoselectivity in the Ring Expansion of Pyrimidines to Give 1,3‐Diazepines.
Authors: Fesenko Anastasia A. , Trafimova Ludmila A. , Albov Dmitry V. , Shutalev Anatoly D. 
Published: June 2015

AbstractThe conversion of pyrimidine (I) into 1,3‐diazepines involves the stereoselective addition of a nucleophile to a bicyclic cyclopropane intermediate to give cis or trans substituted products.
ChemInform Abstract: A New Approach to the Synthesis of 4‐Phosphonylated β‐Lactams.
Authors: Piotrowska Dorota G. , Bujnowicz Aneta , Wroblewski Andrzej E. , Glowacka Iwona E. 
Published: June 2015

AbstractA Kinugasa reaction between phosphonylated nitrones and terminal alkynes leads to the title compounds as mixtures of only partially separable diastereomers.
ChemInform Abstract: Two New Labdane‐Type Diterpene Acids from the Wood of Cunninghamia konishii
Authors: Chang Chi‐I , Li Yen‐Cheng , Yang Chang‐Syan , Chao Che‐Yi , Li Yi‐Jen , Chang Hsun‐Shuo , Huang Ching‐Jeng , Kuo Ching‐Chuan , Kuo Yueh‐Hsiung 
Published: June 2015

Abstractisolation and structure elucidation
ChemInform Abstract: Practical Synthesis of ε‐Carotene.
Authors: Wu Chunlei , Cao Ruiwei , Song Xiaohua , Lv Chunlei , Ye Weidong , Pi Shiqing , Chen Chaohui , Shen Runpu 
Published: June 2015

AbstractThe developed route is supposed to be useful for a large‐scale preparation of the title compound.
ChemInform Abstract: One‐Step Protecting‐Group‐Free Synthesis of Azepinomycin in Water.
Authors: Coggins Adam J. , Tocher Derek A. , Powner Matthew W. 
Published: June 2015

AbstractA direct synthesis of the title compound (III) is achieved by the uncatalyzed reaction of 5‐aminoimidazole‐4‐carboxamide (I) with glycolaldehyde dimer in buffered aqueous solution.
ChemInform Abstract: Hydrothermal Synthesis of N‐Acetyl‐L‐Cysteine‐Capped CuInS2 Nanoparticles.
Authors: Bu Hang‐Beom , Yokota Hiroki , Shimura Kunio , Takahasi Kohji , Taniguchi Taichi , Kim DaeGwi 
Published: June 2015

AbstractThe title nanoparticles are hydrothermally prepared from aqueous mixtures of N‐acetyl‐L‐cysteine, CuCl2, InCl3, and Na2S (autoclave, 180 °C, 5—20 min).
ChemInform Abstract: Phonon and Raman Scattering of Two‐Dimensional Transition Metal Dichalcogenides from Monolayer, Multilayer to Bulk Material
Authors: Zhang Xin , Qiao Xiao‐Fen , Shi Wei , Wu Jiang‐Bin , Jiang De‐Sheng , Tan Ping‐Heng 
Published: June 2015

AbstractReview: 195 refs.
Enhanced γ‐H2AX DNA damage foci detection using multimagnification and extended depth of field in imaging flow cytometry
Authors: Parris Christopher N. , Adam Zahir Sheba , Al‐Ali Hussein , Bourton Emma C. , Plowman Christina , Plowman Piers N. 
Published: June 2015

AbstractAccurate and rapid methods for the detection of DNA damage foci in eukaryotic cells are central to DNA repair studies, which identify differences in DNA repair capacity in cell lines. Such assays have been important in delineating mechanisms of DNA repair in human cells. Previously we were the first to demonstrate the use of imaging flow cytometry for the detection of γ‐H2AX foci in cells exposed to ionizing radiation causing the induction of DNA strand breaks. In this report we extend these studies and show an enhancement of foci quantitation and image resolution using next generation imaging flow cytometry with the Amnis ImagestreamX Mark II. We demonstrate using cell lines derived from normal individuals, and DNA double strand break repair defective cells that the number of foci observed is significantly increased when using 60× as compared to 40× magnification. Also, foci numbers and resolution is further increased with the application of the focus stacking (Extended Depth of Field–EDF) capacity activated. This report represents the first such demonstration of multimagnification and EDF for the enhanced quantitation of DNA damage in cells and provides a level of resolution, which near matches in situ microscopy methods for the detection of γ‐H2AX foci. © 2015 The Authors. Published by Wiley Periodicals Inc. on behalf of ISAC.
Effect of Pulse Width of Square Potential to Remove Silver Interference in the Determination of Mercury(II)
Authors: Farahi A. , Achak M. , El Gaini L. , El Yamani S. , Bakasse M. , El Mhammedi M. A. 
Published: June 2015

AbstractA graphite electrode modified with silver (Ag‐CPE) has been applied to detect mercury(II) using differential pulse voltammetry (DPV). Under optimized conditions, the calibration curve is linear in the range from 5.0×10−8 mol L−1 to 1.0×10−4 mol L−1 of mercury(II). The detection limit was found to be 3.38×10−8 mol L−1 with a relative standard deviation (RSD) of 2.25 % (n=8). The proposed method was successfully applied for the detection of mercury(II) in leachate samples. The Ag‐CP composites were characterized using X‐ray diffraction (XRD), BET adsorption analysis and scanning electron microscopy (SEM).
Electrochemical Determination of Uric Acid, Dopamine and Tryptophan at Zinc Hexacyanoferrate Clay Modified Electrode
Authors: Kemmegne‐Mbouguen Justin Claude , Angnes Lúcio , Mouafo‐Tchinda Edwige , Ngameni Emmanuel 
Published: June 2015

AbstractA Cameroonian smectite clay has been transformed into Zn2+ homoionic form and then used to prepare film modified glassy carbon electrodes and carbon paste electrodes. These electrodes containing Zn2+ were exploited to prepare a mixed valence zinc hexacyanoferrate (ZnHCF). Cyclic voltammetry has been employed to monitor the in situ growth of ZnHCF on clay modified electrodes. Although interesting electrocatalytic properties toward UA were observed with these modified electrodes, the modified carbon paste electrodes were the most suitable for dopamine, uric acid and tryptophan detection and exhibited for these analytes extended linear range, high sensitivities, selectivity and low limit.
The toxic effects of Bisphenol A on the mouse spermatocyte GC‐2 cell line: the role of the Ca2+‐calmodulin‐Ca2+/calmodulin‐dependent protein kinase II axis
Authors: Qian Wenyi , Wang Yixin , Zhu Jingying , Mao Changfei , Wang Qiang , Huan Fei , Cheng Jie , Liu Yanqing , Wang Jun , Xiao Hang 
Published: June 2015

AbstractBisphenol A (BPA), an endocrine‐disrupting chemical (EDC), is known to induce male reproductive toxicity in rodents. However, its toxic effects on the germ cells are still poorly understood. It has been proposed that Ca2+ homeostasis and Ca2+ sensors, including calmodulin (CaM) and calmodulin‐dependent protein kinase II (CaMKII), play critical roles in spermatogenesis. Therefore, in the present study, we aimed to investigate whether a perturbation in Ca2+‐CaM‐CaMKII signaling was involved in the BPA‐induced injury to mouse spermatocyte GC‐2spd (ts) (GC‐2) cells. Our results showed that BPA (range from 0.2 to 20 μM) induced obvious GC‐2 cell injury, including decreased cell viability, the release of mitochondrial cytochrome c and the activation of caspase‐3. However, these processes could be partially abrogated by pretreatment with a Ca2+ chelator (BAPTA/AM), a CaM antagonist (W7) or a CaMKII inhibitor (KN93). These results, taken together, indicate that BPA exposure contributes to male germ cell injury, which may be partially mediated through a perturbation in Ca2+/CaM/CaMKII signaling and the mitochondrial apoptotic process. Copyright © 2015 John Wiley & Sons, Ltd.
Percutaneous transhepatic portal vein stenting for malignant portal vein stenosis secondary to recurrent perihilar biliary cancer
Authors: Mizuno Takashi , Ebata Tomoki , Yokoyama Yukihiro , Igami Tsuyoshi , Sugawara Gen , Mori Yoshine , Suzuki Kojiro , Nagino Masato 
Published: June 2015

AbstractBackgroundTranshepatic portal vein (PV) stenting has been shown to be one of the most important treatments for patients with PV stenosis caused by hepatopancreatobiliary malignancy.MethodsTen consecutive patients with PV stenosis caused by the recurrence of a perihilar biliary malignancy underwent transhepatic PV stenting. A self‐expandable metallic stent was deployed at the stenosis site. The patients were retrospectively analyzed with regard to the procedure, complications, and survival after the stent placement.ResultsThe median interval between the primary resection and the PV stenting was 22 months. The initial hepatic resection was a left trisectionectomy with caudate lobectomy in seven patients, a left hepatectomy with caudate lobectomy in one patient, a right anterior sectionectomy with caudate lobectomy following a left hepatectomy in one patient and a partial liver resection in one patient. The angle of the PV around the stenosis was greater in the patients with PV stenosis located in the right posterior PV. Eight patients with successful PV stent placement were able to receive anticancer treatment, with a median survival of 14 months. The remaining two patients without successful PV stent placement survived less than 6 months.ConclusionsPortal vein stenting might offer relief from the symptoms associated with PV hypertension and the opportunity for sustainable anticancer therapy in patients with recurrent perihilar biliary malignancy.