bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of dietary fiber intake on glycemic control, cardiovascular risk factors and chronic kidney disease in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry
Authors: Fujii Hiroki , Iwase Masanori , Ohkuma Toshiaki , Ogata-Kaizu Shinako , Ide Hitoshi , Kikuchi Yohei , Idewaki Yasuhiro , Joudai Tamaki , Hirakawa Yoichiro , Uchida Kazuhiro , Sasaki Satoshi , Nakamura Udai , Kitazono Takanari 
Published: December 2013

Abstract

Background
Dietary fiber is beneficial for the treatment of type 2 diabetes mellitus, although it is consumed differently in ethnic foods around the world. We investigated the association between dietary fiber intake and obesity, glycemic control, cardiovascular risk factors and chronic kidney disease in Japanese type 2 diabetic patients.

Methods
A total of 4,399 patients were assessed for dietary fiber intake using a brief self-administered diet history questionnaire. The associations between dietary fiber intake and various cardiovascular risk factors were investigated cross-sectionally.

Results
Body mass index, fasting plasma glucose, HbA1c, triglyceride and high-sensitivity C-reactive protein negatively associated with dietary fiber intake after adjusting for age, sex, duration of diabetes, current smoking, current drinking, total energy intake, fat intake, saturated fatty acid intake, leisure-time physical activity and use of oral hypoglycemic agents or insulin. The homeostasis model assessment insulin sensitivity and HDL cholesterol positively associated with dietary fiber intake. Dietary fiber intake was associated with reduced prevalence of abdominal obesity, hypertension and metabolic syndrome after multivariate adjustments including obesity. Furthermore, dietary fiber intake was associated with lower prevalence of albuminuria, low estimated glomerular filtration rate and chronic kidney disease after multivariate adjustments including protein intake. Additional adjustments for obesity, hypertension or metabolic syndrome did not change these associations.

Conclusion
We demonstrated that increased dietary fiber intake was associated with better glycemic control and more favorable cardiovascular disease risk factors including chronic kidney disease in Japanese type 2 diabetic patients. Diabetic patients should be encouraged to consume more dietary fiber in daily life.
Child-rated versus parent-rated quality of life of community-based obese children across gender and grade
Authors: Su Chia-Ting , Wang Jung-Der , Lin Chung-Ying 
Published: December 2013

Abstract

Background
Quality of life (QoL), which can be examined using self-reports or parental reports, might help healthcare providers understand obese children’s subjective well-being in several domains of life. Community-based obese children report their QoL lower than their parents do. However, the differences between child- and parent-reported QoL have neither been tested across gender and grade nor analyzed by item. This study probed the relationship between obesity and QoL item scores in children, and compared child-reported with parent-reported QoL stratified by gender and grade.

Methods
One hundred eighty-seven dyads of 8- to 12-year-old children (60 obese, 127 normal-weight) and their parents were recruited. QoL was assessed using both child- and parent-reported Pediatric Quality of Life Inventory 4.0 (PedsQL) questionnaires.

Results
Regression analyses showed specific difficulties with physical and emotional QoL in third- and fourth-grade obese boys (β = 0.278-0.620), and specific problems with social functioning in fifth- and sixth-grade obese girls (β = 0.337-0.411). Moreover, parents seemed unaware of the specific difficulties that their children faced (β = 0.274-0.435).

Conclusions
Obese children seemed to have their difficulties from third to fifth grade, respectively, and their parents seemed unaware of them. Thus, parents need to be more aware of specific difficulties related to childhood obesity.
CPRMethicillin resistant coagulase-negative staphylococci isolated from South Korean ducks exhibiting tremor
Authors: Han Jee Eun , Hwang Sun Young , Kim Ji Hyung , Shin Sang Phil , Jun Jin Woo , Chai Ji Young , Park Yong Ho , Park Se Chang 
Published: December 2013

Abstract

Background
We describe coagulase-negative staphylococci (CoNS) isolates collected from ducklings exhibiting tremor in South Korea over the period of 2010 to 2011. Screening of antimicrobial susceptibility and analysis of SCCmec elements of CoNS were also investigated.

Results

Staphylococcus cohnii was the most frequent staphylococcus (9 isolates) and S. sciuri (4 isolates), S. lentus (3 isolate), S. simulans (1 isolate) and S. epidermidis (1 isolate) were also detected. Among the 15 antimicrobials tested in this study, resistance against oxacillin (15 isolates, 83.3%) was most frequently observed, but only one isolate (SNUDS-1) possessed mecA. This isolate was shown to possess SCCmec type III; the type 3 ccr complex and the class A mec complex.

Conclusions
Based on these results, isolate SNUDS-1 was shown to possess SCCmec type III; the type 3 ccr complex and the class A mec complex. Although the SCCmec type III is not predominant in human, MR-CoNS (Methicillin resistance Coagulase-negative staphylococci) in food animals should be monitored to prevent the dissemination of antimicrobial resistance genes and resistant pathogens to the community.
Choroid metastases revealing primary clear cell adenocarcinoma of the lung effectively treated with cisplatin and pemetrexed: a case report
Authors: Chang Yueh-Shih , Yeung Ling , Chang Liang-Che , Huang Jen-Seng , Yeh Kun-Yun 
Published: December 2013

Abstract

Introduction
The aim of the present report was to draw the attention of oncologists to the importance of prompt diagnosis of primary clear cell adenocarcinoma of the lung, which allows early initiation of treatment to maintain quality of life.

Case presentation
A 63-year-old Chinese woman initially presented to our facility with multifocal bilateral choroid metastatic lesions that were found to originate from a primary clear cell adenocarcinoma of the lung (T2bN2M1b, stage IV). A thorough ophthalmologic evaluation, study of our patient’s history, imaging studies and comprehensive immunohistochemical staining tests led to the diagnosis of this rare lung tumor.

Conclusions
Although this uncommon cancer is unfortunately already at a late stage when choroid metastases develop, systemic chemotherapy alone is sufficient to preserve vision and gain control over the disease.
Influence of resolution on elevation and slope at watershed scale in Loess Plateau
Authors: Chunmei Wang , Qinke Yang , Hongyan Liu , Weiling Guo , Jupp David LB , Rui Li 
Published: December 2013

Abstract
This article studied the effects of resolution on elevation and slope using Statistical and Geostatistical methods. Xian' Nan watershed in Loess Plateau was taking as the study area. The base data was a 1:10000 topographic map and the resolutions studied in this paper included 5 m, 25 m and 50 m. The results showed that: (1) for elevation and slope data, the mean value, STD value, histogram and semi-variogram changed with resolution reduction. The mean value, STD value became smaller in both elevation and slope cases. Histograms moved to the left which shows there was a decrease of elevation and slope with resolution. The sill for semi-variograms of elevation and slope decreased with resolution reduction; (2) the changes of Mean value; STD and histogram were greater in elevation data than in slope data. (3) By using the Independent Structure model, the semi-variogram could be modeled by 4 components for elevation data and the semi-variogram could be modeled by 3 components for slope data. There was more information in slope than in elevation in the components with short range (short wave-length) information. (4) The influence of resolution reduction was greater in the components with short range, so the degree of influence of resolution reduction was related to the amount of short wave-lengths information. The results of this paper had shown which information was lost with resolution reduction and the reason for the different changes on mean value, STD and histogram for elevation and slope. It could also be used to explain different scaling effects in different terrain areas in the future.
Relationship between seedling and mature vegetation on the hilly-gullied Loess Plateau
Authors: Jia Yan-feng , Jiao Ju-ying , Wang Ning 
Published: December 2013

Abstract
Seedling is an indispensable stage in plant cycle life, and seedling survival is important during natural vegetation restoration, especially on the Loess Plateau. In 2007, we selected 4 plots of Artemisia scoparia communities (ASC) and 4 plots of Artemisia gmelinii + Artemisia giraldii communities (AGC), examined seedling richness, diversity during the rainy season, and examined mature vegetation richness, coverage, and frequency in August. The results showed that seedlings density of ASC were 29 n m-2, 33 n m-2, 20 n m-2 and 31 n m-2 in July to October respectively, and that of AGC were 14 n m-2, 12 n m-2, 6 n m-2 and 9 n m-2 respectively; A. scoparia seedlings represented 53.2% of the total seedlings in ASC, the dominant species in AGC only account for less than 5% of the total seedlings. Most of the seedlings found were belonged to Compositae, Leguminoseae and Gramineae; 80% of seedlings in ASC were mainly comprised of A. scoparia and Lespedeza davurica, while in AGC that consisted of more than 6 species, such as L. davurica, Sophora viciifolia, Dracocephalum moldavicaand, A. gmelinii, Patrinia heterophylla, Heteropappus altaicus so on. Sørensen similarity index between monthly seedlings was approximately 0.47 in ASC and 0.35 in AGC; Sørensen similarity index between seedlings and mature vegetation ranged from 0.18 to 0.34 in ASC, and varied from 0.26 to 0.39 in AGC. These results suggested that seedling establishment would be a bottleneck for natural vegetation restoration when seed supply and seedling emergence were possible.
Pulmonary vascular remodeling and right heart failure in pulmonary hypertension: future role of positron emission tomography in decoding the enigma
Authors: Harms Hendrik J , van de Veerdonk Mariëlle C , Lammertsma Adriaan A , Noordegraaf Anton Vonk , Bogaard Harm Jan 
Published: December 2013

Abstract
Whereas the insights into the cellular and molecular mechanisms of pulmonary arterial hypertension (PAH) and associated right heart failure have increased in recent years, there is a lack of clinical tools to assess the pathobiological mechanisms in patients. Positron emission tomography (PET) provides an array of new possibilities to image and quantify relevant disease processes, including proliferation, angiogenesis, matrix remodeling, shifts in metabolism and neurohormonal signaling. Here we describe the first studies which were conducted to image pulmonary vascular remodeling and right heart failure in vivo and discuss additional targets for imaging which hold great promise for future use in PAH patients.
Procalcitonin-guided therapy in intensive care unit patients with severe sepsis and septic shock – a systematic review and meta-analysis
Authors: Prkno Anna , Wacker Christina , Brunkhorst Frank M , Schlattmann Peter 
Published: December 2013

Abstract
Introduction
Procalcitonin (PCT) algorithms for antibiotic treatment decisions have been studied in adult patients from primary care, emergency department, and intensive care unit (ICU) settings, suggesting that procalcitonin-guided therapy may reduce antibiotic exposure without increasing the mortality rate. However, information on the efficacy and safety of this approach in the most vulnerable population of critically ill patients with severe sepsis and septic shock is missing.

Method
Two reviewers independently performed a systematic search in PubMed, Embase, ISI Web of Knowledge, BioMed Central, ScienceDirect, Cochrane Central Register of Controlled Trials, http://www.ClinicalTrials.gov and http://www.ISRCTN.org.
Eligible studies had to be randomized controlled clinical trials or cohort studies which compare procalcitonin-guided therapy with standard care in severe sepsis patients and report at least one of the following outcomes: hospital mortality, 28-day mortality, duration of antimicrobial therapy, length of stay in the intensive care unit or length of hospital stay. Disagreements about inclusion of studies and judgment of bias were solved by consensus.

Results
Finally seven studies comprising a total of 1,075 patients with severe sepsis or septic shock were included in the meta-analysis.
Both hospital mortality (RR [relative risk]: 0.91, 95%CI [confidence interval]: 0.61; 1.36) and 28-day mortality (RR: 1.02, 95%CI: 0.85; 1.23) were not different between procalcitonin-guided therapy and standard treatment groups.
Duration of antimicrobial therapy was significantly reduced in favor of procalcitonin-guided therapy (HR [hazard ratio]: 1.27, 95%CI: 1.01; 1.53). Combined estimates of the length of stay in the ICU and in hospital did not differ between groups.

Conclusion
Procalcitonin-guided therapy is a helpful approach to guide antibiotic therapy and surgical interventions without a beneficial effect on mortality. The major benefit of PCT-guided therapy consists of a shorter duration of antibiotic treatment compared to standard care.
Trials are needed to investigate the effect of PCT-guided therapy on mortality, length of ICU and in-hospital stay in severe sepsis patients.
Genistein decreases the breast cancer stem-like cell population through Hedgehog pathway
Authors: Fan Panhong , Fan Shujun , Wang Huan , Mao Jun , Shi Yu , Ibrahim Mohammed M , Ma Wei , Yu Xiaotang , Hou Zhenhuan , Wang Bo , Li Lianhong 
Published: December 2013

Abstract
Introduction
The existence of breast cancer stem-like cells (BCSCs) has profound implications for cancer prevention. Genistein, a predominant isoflavone found in soy products, has multiple robust anti-tumor effects in various cancers, especially in the breast and prostate cancer. In this study, we aimed to evaluate genistein inhibition of BCSCs and its potential mechanism by culturing MCF-7 breast cancer cells and implanting these cells into nude mice.

Methods
Cell counting, colony formation and cell apoptosis analysis were used to evaluate the effect of genistein on breast cancer cells’ growth, proliferation and apoptosis. We then used mammosphere formation assay and CD44CD24 staining to evaluate the effect of genistein on BCSCs in vitro. A nude mice xenograft model was employed to determine whether genistein could target BCSCs in vivo, as assessed by real-time polymerase chain reaction (PCR) and immunohistochemical staining. The potential mechanism was investigated utilizing real-time PCR, western blotting analysis and immunohistochemical staining.

Results
Genistein inhibited the MCF-7 breast cancer cells’ growth and proliferation and promoted apoptosis. Both in vitro and in vivo genistein decreased breast cancer stem cells, and inhibited breast cancer stem-like cells through down-regulation of the Hedgehog-Gli1 Signaling Pathway.

Conclusions
We demonstrated for the first time that genistein inhibits BCSCs by down-regulating Hedgehog-Gli1 signaling pathway. These findings provide support and rationale for investigating the clinical application of genistein in treating breast cancer, and specifically by targeting breast cancer stem cells.
Mutagenesis and homologous recombination in Drosophila cell lines using CRISPR/Cas9
Authors: Bassett Andrew R. , Tibbit Charlotte , Ponting Chris P. , Liu Ji-Long 
Published: December 2013

Summary
We have applied the CRISPR/Cas9 system to Drosophila S2 cells to generate targeted genetic mutations in more than 85% of alleles. By targeting a constitutive exon of the AGO1 gene, we demonstrate homozygous mutation in up to 82% of cells, thereby allowing the study of genetic knockouts in a Drosophila cell line for the first time. We have shown that homologous gene targeting is possible at 1–4% efficiency using this system, allowing for the construction of defined insertions and deletions. We demonstrate that a 1 kb homology arm length is optimal for integration by homologous gene targeting, and demonstrate its efficacy by tagging the endogenous AGO1 protein. This technology enables controlled genetic manipulation in Drosophila cell lines, and its simplicity offers the opportunity to study cellular phenotypes genome-wide.
MECHANISM TO INCREASE THE RATIONALITY OF MANAGEMENT OF INFORMATIVE SUPPORT OF THE EDUCATIONAL PROCESS IN THE BRANCHES OF UNIVERSITIES
Authors: Васин Сергей , Vasin Sergey , Яшина Инна , Yashina Inna 
Published: December 2013

The article considers a methodical point of view to evaluating
the rationality of management of informative support of the
educational process in the branches of universities. The factual calculation
is made corresponding figure by the example of several
organizations. The authors created regression models describing the
dependence of the results of the operation of branches of universities
on the level of rationality management of informative support of
their educational process. The article formulates an algorithm for
improving the rationality of management impact on the development
of informative support.
Narrative form and the rhetoric of fashion in the promotional fashion film
Authors: Mijovic Nikola 
Published: December 2013

Abstract
Online promotional fashion film has become a significant aspect of the symbolic production of fashion in the twenty-first century. This article presents a broad overview of the genre’s most prominent aesthetic and formal tendencies. Three approaches to fashion film-making are discussed: first, the non-narrative, where the status of fashion as a designed object is foregrounded; second, the conventional narrative, in which fashion acts as an aspirational symbol; and finally, the ‘organic’ narrative approach, where the visual style and the formal system of the moving image are constructed around clothing. The films discussed include Portent (2009), directed by Nick Knight, Karl Lagerfeld’s Remember Now (2010) and Once Upon a Time ... (2013), and Lucrecia Martel’s Muta (2011). The article assesses this medium in relation to its potential to challenge the existing paradigm associated with the rhetoric of fashion on the one hand, and the narrative film form on the other. Promotional fashion film, while being a form of ‘new media’, is also firmly situated within the domain of postmodernism, which may explain its limited ability to undermine the established dominant representational codes.
Community music and music pedagogy: Collaborations, intersections and new perspectives: A personal reflection
Authors: Deane Kathryn 
Published: December 2013

Abstract
The lenses through which community music and music pedagogy can be viewed are many. A navigation through a symposium on community music and music pedagogy at Ludwig Maximillians University Munich in February 2013 can be provided by examining the purposes of the activities presented in various papers. This approach could address the concerns of a number of speakers about a lack of shared terminology and understanding, and reduce oppositionality sometimes present when we pit community music against music pedagogy.
Building a landscape for Parks
Authors: Gulden Leslie S. 
Published: December 2013

Abstract
Would modernist techniques in design help to ground, clarify and (for lack of a better term) unify postmodern texts for a theatrical audience? Given a script like Suzan-Lori Parks’s. The America Play, how have scenographers dealt with ambiguous stage directions like, ‘Place: A great hole. In the middle of nowhere. The hole is an exact replica of The Great Hole of History’?
Using the questions above, among others, I analyse the scenographic choices in four productions of The America Play. Created in different parts of the United States and in theatres of various sizes, these productions demonstrate that not only can the design aspects be modernist while the script/text is postmodern, but that choosing a modernist design approach could be beneficial to the production. I examined several images from each production, supported by interviews with many of their respective designers, to argue that through the use of various modernist design elements each production offered visual elements that might have helped audiences to relate to the text and provide a way in to the postmodern language. Stated another way, these designs were used to bring the text more ‘down to earth’ by leaning towards visual metaphors to which the audience could relate. Since Parks appears to intentionally neglect any mention of design in the play script, there is a certain freedom offered to any design team, but that freedom also creates challenges. If we accept that this play is a landscape in the tradition of Gertrude Stein than could the best practice for this or other postmodernist plays be to surround them with a modernist design? This article will use primarily Park’s play and the works of postmodern theorists, to argue that the answer is ‘Yes’.
Demon: A View from Above – When director and performers are scenographers
Authors: Thomas James 
Published: December 2013

Abstract
Dmitry Krymov is a Russian artist who has developed an international reputation through work that combines images from paintings, poems, prose, plays, music and popular culture to create phantasmagorical, one-of-a-kind performances. Following no obvious linear narratives and no literary dramaturgy as such, the images built up on Krymov’s stage may be seen as dynamic montages. Montages because they combine visual and aural elements from various sources; dynamic because they are constructed literally before our eyes. Of special interest is the fact that his performance style developed along aside of, and emerged from, his approach to teaching scenography, where designers actually devise and execute the performances.
Recent breakthroughs in carrier depletion based silicon optical modulators
Authors: Reed Graham T. , Mashanovich Goran Z. , Gardes Frederic Y. , Nedeljkovic Milos , Hu Youfang , Thomson David J. , Li Ke , Wilson Peter R. , Chen Sheng-Wen , Hsu Shawn S. 
Published: December 2013

AbstractThe majority of the most successful optical modulators in silicon demonstrated in recent years operate via the plasma dispersion effect and are more specifically based upon free carrier depletion in a silicon rib waveguide. In this work we overview the different types of free carrier depletion type optical modulators in silicon. A summary of some recent example devices for each configuration is then presented together with the performance that they have achieved. Finally an insight into some current research trends involving silicon based optical modulators is provided including integration, operation in the mid-infrared wavelength range and application in short and long haul data transmission links.
Investigation of experimental study of end milling of CFRP composite
Authors: Kiliçkap Erol , Yardimeden Ahmet , Çelik Yahya Hışman 
Published: December 2013

AbstractCarbon fiber-reinforced plastic (CFRP) composites are materials that are difficult to machine due to the anisotropic and heterogeneous properties of the material and poor surface quality, which can be seen during the machining process. The machining of these materials causes delamination and surface roughness owing to excessive cutting forces. This causes the material not to be used. The reduction of damage and surface roughness is an important aspect for product quality. Therefore, the experimental study carried out on milling of CFRP composite material is of great importance. End milling tests were performed at CNC milling vertical machining center. In the experiments, parameters considered for the end milling of CFRP were cutting speed, feed rate, and flute number of end mill. The results showed that damage, surface roughness, and cutting forces were affected by cutting parameters and flute number of end mill. The best machining conditions were achieved at low feed rate and four-flute end mill.