bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of the GGP gene family in potato (Solanum tuberosum L.) and Pepper (Capsicum annuum L.) and its expression analysis under hormonal and abiotic stresses
Authors: Ding Zhiqi , Yao Kangding , Yao Yandong , Pan Xuejuan , Luo Lizhen , Li Long , Wang Chunlei , Liao Weibiao 
Published: July 2024

AbstractGDP-l-galactose phosphorylase (GGP) is a key rate-limiting enzyme in plant ascorbic acid synthesis, which plays an important role in plant growth and development as well as stress response. However, the presence of GGP and its function in potato and pepper are not known. In this study, we first identified two GGP genes in each potato and pepper genomes using a genome-wide search approach. We then analyzed their physicochemical properties, conserved domains, protein structures and phylogenetic relationships. Phylogenetic tree analysis revealed that members of the potato and pepper GGP gene families are related to eggplant (Solanum melongena L.), Arabidopsis (Arabidopsis thaliana L.), tobacco (Nicotiana tabacum L.) and tomato (Solanum lycopersicum L.), with tomato being the most closely related. The promoter sequences mainly contain homeopathic elements such as light-responsive, hormone-responsive and stress-responsive, with light-responsive elements being the most abundant. By analyzing the structure of the genes, it was found that there is no transmembrane structure or signal peptide in the GGP gene family of potatoes and peppers, and that all of its members are hydrophilic proteins. The expression profiles of different tissues show that StGGP1 has the highest expression levels in leaves, StGGP2 has the highest expression levels in stamens, and CaGGPs have the highest expression levels in the early stages of fruit development (Dev1). It was found that StGGPs and CaGGPs genes showed different response to phytohormones and abiotic stresses. Abscisic acid (ABA) treatment induced the most significant change in the expression of StGGPs, while the expression of CaGGPs showed the most pronounced change under methyl jasmonate (MeJA) treatment. StGGPs responded mainly to dark treatment, whereas CaGGPs responded mainly to NaCl stress. These results provide an important basis for a detailed study about the functions of GGP homologous genes in potato and pepper in response to abiotic stresses.
Study on the dynamic response and roadways stability during mining under the disturbance of hard roof break
Authors: Peng Kong , Chang Liu , Dechuan Yang , Shihui Li , Ruiju Jin 
Published: July 2024

AbstractUnder the condition that the working face was directly covered with hard roof, the abrupt breaking of hard roof release significant amount of energy, thus prone to triggering dynamic disasters such as roadway instability or rockburst. This paper based on the engineering background of the Xieqiao Coal Mine's 11,618 working face, a numerical simulation method was put forward to study the dynamic response of roadway under the disturbance of hard roof breaking and proposed an evaluation index IC for roadway stability. Research indicates that the elastic energy released during the periodic weighting of the hard roof is higher than that released during the first weighting. Under the dynamic disturbance caused by hard roof breaking, the peak stresses of the roadway was slight decreased, accompanied by a significant increase in the range of stress concentration and plastic zone expansion. Roadway deformation patterns are significantly influenced by hard roof breaking, with noticeable increases in deformation on the roof and right side. During the period of hard roof breaking, the possibility of instability of the roadway increase significantly due to the disturbance caused by the dynamic load. The research results reveal the instability mechanism of roadway under the condition of hard roof, and provide a more reliable basis for evaluating the stability of roadway.
A non-invasive diagnostic nomogram for CHB-related early cirrhosis: a prospective study
Authors: Chen Yuxia , Wei Meijuan , Chen Meng , Wu Chenyu , Ding Hongbing , Pan Xingnan 
Published: July 2024

AbstractThis study aimed to construct a non-invasive diagnostic nomogram based on high-frequency ultrasound and magnetic resonance imaging results for early liver cirrhosis patients with chronic hepatitis B (CHB) which cannot be detected by conventional non-invasive examination methods but can only be diagnosed through invasive liver puncture for pathological examination. 72 patients with CHB were enrolled in this prospective study, and divided into S4 stage of liver cirrhosis and S0-S3 stage of non-liver cirrhosis according to pathological findings. Binary logistic regression analysis was performed to identify independent predictors, and a diagnostic nomogram was constructed for CHB-related early cirrhosis. It was validated and calibrated by bootstrap self-extraction. Binary logistic regression analysis showed that age (OR 1.14, 95% CI (1.04–1.27)), right hepatic vein diameter (OR 0.43, 95% CI 0.23–0.82), presence or absence of nodules (OR 31.98, 95% CI 3.84–266.08), and hepatic parenchymal echogenicity grading (OR 12.82, 95% CI 2.12–77.51) were identified as independent predictive indicators. The nomogram based on the 4 factors above showed good performance, with a sensitivity and specificity of 90.70% and 89.66%, respectively. The area under the curve (AUC) of the prediction model was 0.96, and the predictive model showed better predictive performance than APRI score (AUC 0.57), FIB-4 score (AUC 0.64), INPR score (AUC 0.63), and LSM score (AUC 0.67). The calibration curve of the prediction model fit well with the ideal curve, and the decision curve analysis showed that the net benefit of the model was significant. The nomogram in this study can detect liver cirrhosis in most CHB patients without liver biopsy, providing a direct, fast, and accurate practical diagnostic tool for clinical doctors.
Direct and indirect pathways for heterosynaptic interaction underlying developmental synapse elimination in the mouse cerebellum
Authors: Nakayama Hisako , Miyazaki Taisuke , Abe Manabu , Yamazaki Maya , Kawamura Yoshinobu , Choo Myeongjeong , Konno Kohtarou , Kawata Shinya , Uesaka Naofumi , Hashimoto Kouichi , Miyata Mariko , Sakimura Kenji , Watanabe Masahiko , Kano Masanobu 
Published: July 2024

AbstractDevelopmental synapse elimination is crucial for shaping mature neural circuits. In the neonatal mouse cerebellum, Purkinje cells (PCs) receive excitatory synaptic inputs from multiple climbing fibers (CFs) and synapses from all but one CF are eliminated by around postnatal day 20. Heterosynaptic interaction between CFs and parallel fibers (PFs), the axons of cerebellar granule cells (GCs) forming excitatory synapses onto PCs and molecular layer interneurons (MLIs), is crucial for CF synapse elimination. However, mechanisms for this heterosynaptic interaction are largely unknown. Here we show that deletion of AMPA-type glutamate receptor functions in GCs impairs CF synapse elimination mediated by metabotropic glutamate receptor 1 (mGlu1) signaling in PCs. Furthermore, CF synapse elimination is impaired by deleting NMDA-type glutamate receptors from MLIs. We propose that PF activity is crucial for CF synapse elimination by directly activating mGlu1 in PCs and indirectly enhancing the inhibition of PCs through activating NMDA receptors in MLIs.
Gstp1 negatively regulates blood pressure in hypertensive rat via promoting APLNR ubiquitination degradation mediated by Nedd4
Authors: Lei Jianzhen , Zheng Fen , Chen Luyao , Zhang Ruyi , Yang Yang , Yin Zhimin , Luo Lan 
Published: July 2024

Abstract
Hypertension is a leading risk factor for disease burden worldwide. Vascular contraction and remodeling contribute to the development of hypertension. Glutathione S-transferase P1 (Gstp1) plays several critical roles in both normal and neoplastic cells. In this study, we investigated the effect of Gstp1 on hypertension as well as on vascular smooth muscle cell (VSMC) contraction and phenotypic switching. We identified the higher level of Gstp1 in arteries and VSMCs from hypertensive rats compared with normotensive rats for the first time. We then developed Adeno-associated virus 9 (AAV9) mediated Gstp1 down-regulation and overexpression in rats and measured rat blood pressure by using the tail-cuff and the carotid catheter method. We found that the blood pressure of spontaneously hypertensive rats (SHR) rose significantly with Gstp1 down-regulation and reduced apparently after Gstp1 overexpression. Similar results were obtained from the observations of 2-kidney-1-clip renovascular (2K1C) hypertensive rats. Gstp1 did not influence blood pressure of normotensive Wistar-Kyoto (WKY) rats and Sprague-Dawley (SD) rats. Further in vitro study indicated that Gstp1 knockdown in SHR-VSMCs promoted cell proliferation, migration, dedifferentiation and contraction, while Gstp1 overexpression showed opposite effects. Results from bioinformatic analysis showed that the Apelin/APLNR system was involved in the effect of Gstp1 on SHR-VSMCs. The rise in blood pressure of SHR induced by Gstp1 knockdown could be reversed by APLNR antagonist F13A. We further found that Gstp1 enhanced the association between APLNR and Nedd4 E3 ubiquitin ligases to induce APLNR ubiquitination degradation. Thus, in the present study, we discovered a novel anti-hypertensive role of Gstp1 in hypertensive rats and provided the experimental basis for designing an effective anti-hypertensive therapeutic strategy.
Is the TCA cycle malate dehydrogenase-citrate synthase metabolon an illusion?
Authors: Omini Joy , Dele-Osibanjo Taiwo , Kim Heejeong , Zhang Jing , Obata Toshihiro 
Published: July 2024

Abstract
This review discusses the intriguing yet controversial concept of metabolons, focusing on the malate dehydrogenase-citrate synthase (MDH-CISY) metabolon as a model. Metabolons are multienzyme complexes composed of enzymes that catalyze sequential reactions in metabolic pathways. Metabolons have been proposed to enhance metabolic pathway efficiency by facilitating substrate channeling. However, there is skepticism about the presence of metabolons and their functionality in physiological conditions in vivo. We address the skepticism by reviewing compelling evidence supporting the existence of the MDH-CISY metabolon and highlighting its potential functions in cellular metabolism. The electrostatic interaction between MDH and CISY and the intermediate oxaloacetate, channeled within the metabolon, has been demonstrated using various experimental techniques, including protein–protein interaction assays, isotope dilution studies, and enzyme coupling assays. Regardless of the wealth of in vitro evidence, further validation is required to elucidate the functionality of MDH-CISY metabolons in living systems using advanced structural and spatial analysis techniques.
Charge sign dependence of recurrent Forbush decreases in 2016–2017
Authors: Romaneehsen L. , Heber B. , Marquardt J. 
Published: July 2024

Context. This study investigates the periodicities of galactic cosmic ray flux attributed to corotating interaction regions (CIRs) using Alpha Magnetic Spectrometer (AMS-02) data from late 2016 to early 2017.
Aims. We determine the rigidity dependence of recurrent Forbush decrease (RFD) amplitudes induced by CIRs for different particles with a focus on charge sign.
Methods. We carried out a frequency analysis using a Lomb-Scargle algorithm and superposed epoch analysis for all particles. For protons and helium, we compared the results with a single Forbush decrease (FD) analysis.
Results. Our results reveal that the rigidity dependence of proton amplitudes attributed to the northern coronal hole is in qualitative agreement with previous findings. In contrast, the amplitudes attributed to the southern coronal hole show no rigidity dependence. Furthermore, the amplitude of the helium modulation exceeds that of protons, in line with the observation for long-term modulation. For positrons, statistical limitations stand in the way of any definitive conclusions. In comparison to the positively charged particles, the modulation behavior of electrons reveals a different pattern.
Hüftimpingement im Tanzsport
Authors: Bohnsack Michael 
Published: July 2024

ZusammenfassungDie verschiedenen Formen des morphologischen Hüftimpingements führen insbesondere bei jungen und aktiven Menschen häufig zu Beschwerden. Sportarten mit einer wiederkehrend hohen Dynamik in der Hüftbeugung und Rotation sind prädisponiert, das Einklemmen im oder am Hüftgelenk regelmäßig auszulösen und mögliche Strukturschäden zu verstärken. Neben Fußball und Hockey treten vor allem beim Tanzsport bei Patienten mit Hüftimpingement früh und intensiv Belastungsschmerzen auf.
Health and Performance Screenings im professionellen Bühnentanz
Authors: Hauschild Anja , Arens Tabea , Richter Martha 
Published: July 2024

ZusammenfassungProfessionelle Bühnentänzer*innen haben ein hohes Risiko, sich zu verletzen. Anders als bei
Leistungssportlern haben sich bisher aber nur wenige Testverfahren etabliert, die das Verletzungsrisiko
erfassen und so dazu beitragen können, verletzungsbedingte Ausfälle zu verringern. Die Autorinnen dieses
Artikels wollen das ändern.
Interprofessionelles Team-Training für Pflegeauszubildende und
Medizinstudierende in der Pädiatrie: analoge und digitale Formate im
Vergleich
Authors: Fleig Katharina , Tiroke Petra , Pittau Fabian , Mücke Urs 
Published: July 2024

Zusammenfassung
Hintergrund Die Kinderheilkunde stellt höchste Anforderungen an
interprofessionelle Teams. Obwohl sich Ausbildung und Studium weiterentwickeln,
sind interprofessionelle Lehreinheiten mit analoger und digitaler
Vermittlungsmöglichkeit im deutschsprachigen Raum selten.
Methode Seit 2018 wird ein freiwilliges eintägiges Teamtraining namens
„SICKO Junior“ für Pflegeauszubildende und Medizinstudierende regelmäßig analog
und zwischenzeitlich digital durchgeführt. Evaluationsergebnisse zum analogen
und digitalen Format werden verglichen. Inhalte des eintägigen Workshops
orientieren sich an einem Konzept für Mitarbeiter:innen. Exemplarisch wird
Kommunikation in der Visite in Simulationen reflektiert, Training am Simulator
für Lumbalpunktionen dient dem Perspektivwechsel.
Ergebnisse Insgesamt 104 Teilnehmer:innen (21 digital) haben teilgenommen.
Die Weiterempfehlungsrate liegt bei 100%. Alle Teilnehmer:innen sind davon
überzeugt, dass sich der Workshop positiv auf die gemeinsame interprofessionelle
Arbeit auswirkt. Es zeigten sich keine signifikanten Unterschiede in der
Bewertung der einzelnen Workshop-Elemente zwischen den digitalen und analogen
Trainings.
Diskussion Die vorliegende Arbeit unterstreicht den positiven Einfluss
unabhängig von der Vermittlungsform (analog vs. digital). Die Darstellung bildet
einen Blueprint für eine Dissemination. Eine curriculare Einbindung erscheint
erstrebenswert.Schlussfolgerung Freiwillige interprofessionelle Teamtrainings
für Pflegeauszubildende und Medizinstudierende mit Fokus auf Kommunikation und
Fehlerkultur erfreuen sich in digitaler Form ebenso großer Teilnahmebereitschaft
wie analog. Zukünftige Untersuchungen sollten den Einfluss auf
Kompetenzentwicklung und Sicherheitskultur beleuchten.
Scientific Contributions of Prof. Valentin Felixovich Voyno-Yasenetsky (Saint Luke of Simferopol; 1877–1961) to Surgical Operations of the Nervous System
Authors: Koletsas Vassileios , Mavridis Ioannis , Pyrgelis Efstratios-Stylianos , Georgiadis Georgios , Vadikolias Konstantinos , Birbilis Theodossios A. 
Published: July 2024

AbstractValentin Felixovich Voyno-Yasenetsky (VFVY; also known as Saint Luke of Simferopol) was a famous professor of anatomy and surgery of the previous century. He was a particularly skilled surgeon, proficient in various surgical subspecialties, with main interest in regional anesthesia and pyogenic infections. The primary aim of this article is to explore his scientific contributions to surgical operations of the nervous system. His contributions are in three primary fields, namely, neuroanatomy, neurosurgery, and regional anesthesia. His work is characterized by meticulous descriptions of various anatomical structures of the brain and skull and of the intraoperative findings of his neurosurgical procedures. He clarified neurosurgical terms and described neurosurgical techniques. He also provided advice regarding the safety of neurosurgical procedures. Furthermore, he pioneered in techniques for regional anesthesia of the sciatic and trigeminal nerves. His exceptional talent as a scientist and surgeon, as well as his contributions to the neurosciences, makes him an exemplary doctor for modern neurosurgeons.
Recurrent Syncope and Cardiopulmonary Resuscitation Due to a Papillary Fibroelastoma
Authors: Escherich Teresa , Czesla Markus , Massoudy Parwis 
Published: July 2024

AbstractSymptoms of papillary fibroelastomas are often related to thromboembolic events but are rarely caused by a mechanical impairment of blood supply by the tumor itself. We describe a case of a papillary fibroelastoma in a 91-year-old female patient leading to a cardiac arrest through intermittent occlusion of the left coronary artery.
France’s militarized interstate disputes: diversion from domestic problems?
Authors: Bussmann Margit 
Published: July 2024

AbstractA large body of research investigates whether democracies’ decisions to intervene militarily are guided by external threats and strategic considerations or whether domestic factors play the predominant role. Foreign military intervention can create a “rally-round-the-flag” effect and might be used to divert attention away from domestic problems. A reassessment of diversionary theory for France, as one of the most militarily active European powers, which has hardly been subject to rigorous empirical research so far, is not supportive of the theory’s theses. There is only weak support that France is more likely to intervene in months with low presidential popularity and no evidence of a systematic rally effect after France gets involved in military disputes. With few exceptions, presidential approval ratings do not improve.
Edge-based strategies enhance cooperation in intertwined dynamics of cooperation and synchronization
Authors: Dong Yuting , Dai Xiangfeng , Lu Yikang , Jin Haoyu , Shi Lei 
Published: July 2024

Abstract
In various ecosystems and human societies, living organisms and systems often exhibit cooperative and synchronous behaviors during survival. Recently, co-evolutionary models of cooperation and synchronization have shed light on the underlying mechanisms driving such behaviors, offering an intriguing avenue for studying these phenomena. However, current research predominantly focuses on a point-strategy decision mode, where each individual is limited to taking the same actions towards its neighbors. Such an assumption implies that an individual is unable to differentiate its neighbors and adjust its strategy accordingly, making it difficult to capture the complexity and diversity of interactive behaviors observed in reality. To this end, we introduce the interaction mode based on the edge-strategy and investigate how synchronization and cooperation co-evolve under interaction diversity. Specifically, we explore a scenario in which individuals can adopt different strategic decisions toward their neighbors based on their differences, thereby extending the traditional point strategy. Our research clarifies the positive role of interaction diversity in alleviating the evolutionary Kuramoto’s dilemma. Moreover, it provides new insights and ideas for comprehending the influence of edge-strategy on the co-evolution of cooperative and synchronous behaviors.
Experimental and computational Insights Into the magnetic anisotropy and magnetic behaviour of layered room-temperature ferromagnet Cr1.38Te2
Authors: Purwar Shubham , Bhowmik Tushar Kanti , Rajesh Tijare Mandar , Gorai Anupam , Chittari Bheema Lingam , Thirupathaiah Setti 
Published: July 2024

Abstract
We investigate the structural, magnetocrystalline anisotropy, critical behaviour, and magnetocaloric effect in the layered room-temperature monoclinic ferromagnet Cr1.38Te2. The critical behavior is studied by employing various techniques such as the modified Arrott plot (MAP), the Kouvel-Fisher method (KF), and the critical isothermal analysis (CI) around the Curie temperature (T

C
) of 316 K. The derived critical exponents are self-consistent and obey the rescaling analysis. The Monte-Carlo simulations reproduce the experimentally obtained critical exponents. However, the derived critical exponents do not suggest any single universality class of the magnetic interactions. On the other hand, the renormalization group (RG) theory suggests 3D-Ising type long-range exchange interactions [J(r)], decaying with distance (r) as J(r) = r
−(d+σ) = r
−4.73. Further, magnetocrystalline anisotropy energy density (K
u
) is found to be temperature dependent. The ground state magnetic easy-axis (b-axis) is identified by analyzing the magnetocrystalline anisotropy energy (MAE) using the density functional theory calculations. Maximum entropy change -

Δ

S

m

max

≈2.51 J/kg-K is found near the T

C
.
A view of optical soliton solution of the coupled Schrödinger equation with a different approach
Authors: Özkan Ayten , Özdemir Nagehan , Özkan Erdoĝan Mehmet 
Published: July 2024

Abstract
The goal of this study is to investigate to optical soliton solution of the nonlinear coupled space-time Schrödinger equation using the Beta derivative and Sine-Gordon Expansion Method. All calculations in this study are made using some software program and the solutions obtained are substituted in the equations. New soliton solutions have been found using the suggested method for solving these problems. The solutions obtained have important areas of use in the fields of mathematical physics, in the field of quantum physics, optic and engineering.
Noise analysis of six pulsars and a limit on the gravitational wave background
Authors: Wang J 
Published: July 2024

Abstract
The direct detection of ultra-low frequency gravitational waves (GWs, 10−9 − 10−6 Hz) using pulsar timing arrays (PTAs) is a significant application of millisecond pulsars. The initial detection of GWs in the nano-Hertz range will probably be an isotropic stochastic GW background (GWB) emitted by the combination of merging super-massive black hole binaries (SMBHBs). In this study, we utilize data from six pulsars collected with four European PTA (EPTA) telescopes to place an upper limit on the GWB amplitude

A
=

2.34

−
1.32

+
0.75

×

10

−
15

(95%) as a function of the spectral slope α = − 2/3, corresponding to a GWB generated by inspiraling SMBHBs. The posterior for the amplitude that we obtained from the six brightest EPTA pulsars is strongly consistent with previously published upper limits set by the three PTAs. We also compare the sensitivity of our reprocessed pulsar pulse times of arrival (ToAs) determined by the superior ToA creation method, which utilizes a combination of the best template generation algorithm and template-matching algorithm, with the ToAs determined by the EPTA groups. Our analysis shows that the reprocessed ToAs obtained with the superior ToA creation method yield narrower posteriors, indicating an overall increased sensitivity to GW.
The study of nonlinear fractional boundary value problems involving the p-Laplacian operator
Authors: Khan Asad Ullah , Khan Rahman Ullah , Ali Gohar , Kamran  , Aljawi Salma 
Published: July 2024

AbstractThep-Laplacian has attracted considerable attention in numerous fields such as mechanics, image processing and game theory. It is a nonlinear operator which has been used in the modelling and qualitative aspects in numerous problems. In this research work, we propose a new nonlinear fractional differential equation involving thep-Laplacian, which include the generalized Caputo fractional derivatives. We investigate the existence and uniqueness of solutions to our proposed problem through the application using the Banach and Schauder’s fixed-point theorems. Additionally, we illustrate the practical applicability of our findings by applying them to a specific example, thereby validating their efficacy.