bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Depressive Symptoms and Incidence of First Stroke Among Middle‐Aged and Older US Adults
Authors: Gilsanz Paola , Walter Stefan , Tchetgen Tchetgen Eric J. , Patton Kristen K. , Moon J. Robin , Capistrant Beatrix D. , Marden Jessica R. , Kubzansky Laura D. , Kawachi Ichiro , Glymour M. Maria 
Published: May 2015

Background
Although research has demonstrated that depressive symptoms predict stroke incidence, depressive symptoms are dynamic. It is unclear whether stroke risk persists if depressive symptoms remit.

Methods and Results

Health and Retirement Study participants (n=16 178, stroke free and noninstitutionalized at baseline) were interviewed biennially from 1998 to 2010. Stroke and depressive symptoms were assessed through self‐report of doctors’ diagnoses and a modified Center for Epidemiologic Studies ‐ Depression scale (high was ≥3 symptoms), respectively. We examined whether depressive symptom patterns, characterized across 2 successive interviews (stable low/no, onset, remitted, or stable high depressive symptoms) predicted incident stroke (1192 events) during the subsequent 2 years. We used marginal structural Cox proportional hazards models adjusted for demographics, health behaviors, chronic conditions, and attrition. We also estimated effects stratified by age (≥65 years), race or ethnicity (non‐Hispanic white, non‐Hispanic black, Hispanic), and sex. Stroke hazard was elevated among participants with stable high (adjusted hazard ratio 2.14, 95%
CI
1.69 to 2.71) or remitted (adjusted hazard ratio 1.66, 95%
CI
1.22 to 2.26) depressive symptoms compared with participants with stable low/no depressive symptoms. Stable high depressive symptom predicted stroke among all subgroups. Remitted depressive symptoms predicted increased stroke hazard among women (adjusted hazard ratio 1.86, 95%
CI
1.30 to 2.66) and non‐Hispanic white participants (adjusted hazard ratio 1.66, 95%
CI
1.18 to 2.33) and was marginally associated among Hispanics (adjusted hazard ratio 2.36, 95%
CI
0.98 to 5.67).

Conclusions
In this cohort, persistently high depressive symptoms were associated with increased stroke risk. Risk remained elevated even if depressive symptoms remitted over a 2‐year period, suggesting cumulative etiologic mechanisms linking depression and stroke.
Clusterless Decoding of Position from Multiunit Activity Using a Marked Point Process Filter
Authors: Deng Xinyi , Liu Daniel F. , Kay Kenneth , Frank Loren M. , Eden Uri T. 
Published: May 2015

Point process filters have been applied successfully to decode neural signals and track neural dynamics. Traditionally these methods assume that multiunit spiking activity has already been correctly spike-sorted. As a result, these methods are not appropriate for situations where sorting cannot be performed with high precision, such as real-time decoding for brain-computer interfaces. Because the unsupervised spike-sorting problem remains unsolved, we took an alternative approach that takes advantage of recent insights into clusterless decoding. Here we present a new point process decoding algorithm that does not require multiunit signals to be sorted into individual units. We use the theory of marked point processes to construct a function that characterizes the relationship between a covariate of interest (in this case, the location of a rat on a track) and features of the spike waveforms. In our example, we use tetrode recordings, and the marks represent a four-dimensional vector of the maximum amplitudes of the spike waveform on each of the four electrodes. In general, the marks may represent any features of the spike waveform. We then use Bayes’s rule to estimate spatial location from hippocampal neural activity. We validate our approach with a simulation study and experimental data recorded in the hippocampus of a rat moving through a linear environment. Our decoding algorithm accurately reconstructs the rat’s position from unsorted multiunit spiking activity. We then compare the quality of our decoding algorithm to that of a traditional spike-sorting and decoding algorithm. Our analyses show that the proposed decoding algorithm performs equivalent to or better than algorithms based on sorted single-unit activity. These results provide a path toward accurate real-time decoding of spiking patterns that could be used to carry out content-specific manipulations of population activity in hippocampus or elsewhere in the brain.
Comments and Correction on ”U-Processes and Preference Learning” (Neural Computation Vol. 26, pp. 2896–2924, 2014)
Authors: Rejchel Wojciech , Li Hong , Ren Chuanbao , Li Luoqing 
Published: May 2015

This note corrects an error in the proof of corollary 1 of Li et al. ( 2014 ). The original claim of the contraction principle in appendix D of Li et al. no longer holds.
Long-Period Tides in an Atmospherically Driven, Stratified Ocean
Authors: Ponte Rui M. , Chaudhuri Ayan H. , Vinogradov Sergey V. 
Published: May 2015

AbstractLong-period tides (LPT) are studied using a stratified, primitive equation model on a global domain and in the presence of a fully developed, atmospherically forced ocean general circulation. The major LPT constituents, from termensual to nodal (18.6 yr) periods, are examined. Ocean circulation variability can overwhelm the longest tide signals and make inferring LPT from data difficult, but model results suggest that bottom pressure offers cleaner signal-to-noise ratios than sea level, particularly at low latitudes where atmospherically driven variability is substantially stronger at the surface than at the bottom. Most tides exhibit a significant large-scale dynamic response, with the tendency for weaker nonequilibrium signals in the Atlantic compared to the Pacific as seen in previous studies. However, across most tidal lines, the largest dynamic signals tend to occur in the Arctic and Nordic Seas and also in Hudson Bay. Bathymetry and coastal geometry contribute to the modeled nonequilibrium behavior. Baroclinic effects tend to increase with the tidal period. Apart from short spatial-scale modulations associated with topographic interactions, the excitation of various propagating baroclinic wave modes is clearly part of the modeled LPT, particularly at tropical latitudes, for fortnightly and longer-period tides.
Off-pump right atrial surgery: Vena caval inflow occlusion in cardiac lesions
Authors: Torabi Asad John , Dobrilovic Nikola , Raman Jai S 
Published: May 2015

Background Vena caval inflow occlusion, despite its utility in pediatrics, is rarely used in adults. We report the use of inflow occlusion in adults when cardiopulmonary bypass is contraindicated. Methods Between January 1999 and July 2014, 35 patients in 3 hospitals presented with right-sided cardiac lesions; 27 had right-sided endocarditis with sepsis despite maximal medical therapy, the rest had organized sterile masses with embolic potential in the right side of the heart. Comorbidities included immunosuppression, malignancy, and dialysis-dependent renal failure. Twelve patients had heparin-induced thrombocytopenia. Using inflow occlusion on a beating heart, tricuspid valve vegetectomy was performed in 23 patients, vegetectomy and tricuspid valve repair in 3, removal of infected pacing leads in 7, and removal of a migrated inferior vena cava filter in 1. Eight patients had a single 2-min period of vena caval inflow occlusion, and 25 had additional periods of vena caval inflow occlusion after periods of reperfusion. The first 23 procedures were performed through a sternotomy. Nine patients underwent a right minithoracotomy (redo in 2). Results There were no deaths. Infected patients had resolution of sepsis and improvement in respiratory status. Three patients had moderate tricuspid regurgitation, the rest had trivial to mild tricuspid regurgitation. One patient had a transient neurological deficit postoperatively, and one had late empyema. Conclusion Removal of infective material, sterile masses, and retained foreign bodies can safely be performed under vena caval inflow occlusion when cardiopulmonary bypass is contraindicated.
Occupations and personal projects: A comparison of the concepts
Authors: Arcand-Dusseault Caroline , Egan Mary 
Published: May 2015

Introduction The concept of personal projects has been used in occupational therapy research to understand occupation better. However, no clear distinction has been made between personal projects and occupations. An argumentative review was carried out to determine if the concepts of occupation, as outlined in the Canadian Model of Occupational Performance and Engagement and the Person Environment Occupation Model and personal projects are interchangeable. Method Definitions of each concept and seven points of comparison were identified through reading and discussion of key material related to: framework and origins; association with health and well-being; consideration of the environment; individualized and self-directed nature; consideration of aspects of the person; categories; and balance. Findings Occupation and personal projects represent similar concepts when they refer to concrete and time-limited activities. More abstract and extended personal projects may be broken down into more concrete, shorter-term occupations. Differences were noted with respect to consideration of the environment, aspects of the person, categories and balance. Conclusion Differences in the way the environment, aspects of the person, categories and balance are considered in personal projects may provide helpful insights for occupational therapists as they attempt to practice in a client-centered, strengths-based manner with a focus on occupation.
Flow-diverter stenting of post-traumatic bilateral anterior cerebral artery pseudoaneurysm: A case report
Authors: Giorgianni Andrea , Pellegrino Carlo , Minotto Renzo , Mercuri Anna , Frattini Lara , Baruzzi Fabio , Valvassori Luca 
Published: May 2015

The use of flow-diverter (FD) stents in recent years has positively changed the therapeutic approach to some vascular diseases, especially of certain types of aneurysms. This paper describes the case of a young patient after a major head trauma causing multiple skull fractures. The trauma occasioned two pseudoaneurysms from the A1 segment of the right anterior cerebral artery and from the A2 segment of the left anterior cerebral artery. Both lesions were treated with two Pipeline devices (ev3, Irvine, CA, USA) in two different sessions. The CT study and angiographic investigations performed in the following month showed a complete resolution of the post-traumatic pseudoaneurysmal lesions. Although the use of FD stents is described in the literature, particularly in the treatment of selected aneurysms, this paper shows good technical results in the use of these stents in cases of intracranial post-traumatic pseudoaneurysms with clinical improvement.
Use of an Intravascular Fluorescent Continuous Glucose Sensor in ICU Patients
Authors: Strasma Paul J. , Finfer Simon , Flower Oliver , Hipszer Brian , Kosiborod Mikhail , Macken Lewis , Sechterberger Marjolein , van der Voort Peter H. J. , DeVries J. Hans , Joseph Jeffrey I. 
Published: May 2015

Background: Hyperglycemia and hypoglycemia are associated with adverse clinical outcomes in intensive care patients. In product development studies at 4 ICUs, the safety and performance of an intravascular continuous glucose monitoring (IV-CGM) system was evaluated in 70 postsurgical patients. Methods: The GluCath System (GluMetrics, Inc) used a quenched chemical fluorescence mechanism to optically measure blood glucose when deployed via a radial artery catheter or directly into a peripheral vein. Periodic ultrasound assessed blood flow and thrombus formation. Patient glucose levels were managed according to the standard of care and existing protocols at each site. Reference blood samples were acquired hourly and compared against prospectively calibrated sensor results. Results: In all, 63 arterial sensors and 9 venous sensors were deployed in 70 patients. Arterial sensors did not interfere with invasive blood pressure monitoring, sampling or other aspects of patient care. A majority of venous sensors (66%) exhibited thrombus on ultrasound. In all, 89.4% (1383/1547) of arterial and 72.2% (182/252) of venous measurements met ISO15197:2003 criteria (within 20%), and 72.7% (1124/1547) of arterial and 56.3% (142/252) of venous measurements met CLSI POCT 12-A3 criteria (within 12.5%). The aggregate mean absolute relative difference (MARD) between the sensors and the reference was 9.6% for arterial and 14.2% for venous sensors. Conclusions: The GluCath System exhibited acceptable accuracy when deployed in a radial artery for up to 48 hours in ICU patients after elective cardiac surgery. Accuracy of venous deployment was substantially lower with significant rates of intravascular thrombus observed using ultrasound.
Pre-Osteoarthritis
Authors: Ryd Leif , Brittberg Mats , Eriksson Karl , Jurvelin Jukka S. , Lindahl Anders , Marlovits Stefan , Möller Per , Richardson James B. , Steinwachs Matthias , Zenobi-Wong Marcy 
Published: May 2015

Objective An attempt to define pre-osteoarthritis (OA) versus early OA and definitive osteoarthritis. Methods A group of specialists in the field of cartilage science and treatment was formed to consider the nature of OA onset and its possible diagnosis. Results Late-stage OA, necessitating total joint replacement, is the end stage of a biological process, with many previous earlier stages. Early-stage OA has been defined and involves structural changes identified by arthroscopy or radiography. The group argued that before the “early-stage OA” there must exist a stage where cellular processes, due to the presence of risk factors, have kicked into action but have not yet resulted in structural changes. The group suggested that this stage could be called “pre-osteoarthritis” (pre-OA). Conclusions The group suggests that defining points of initiation for OA in the knee could be defined, for example, by traumatic episodes or surgical meniscectomy. Such events may set in motion metabolic processes that could be diagnosed by modern MRI protocols or arthroscopy including probing techniques before structural changes of early OA have developed. Preventive measures should preferably be applied at this pre-OA stage in order to stop the projected OA “epidemic.”
Assessing knowledge, perceptions and attitudes to pain management among medical and nursing students: a review of the literature
Authors: Ung Andrew , Salamonson Yenna , Hu Wendy , Gallego Gisselle 
Published: May 2015

Introduction: Chronic pain results in significant personal, societal and economic burden. Doctors and nurses have a pivotal role in patient pain management. In order to determine the effectiveness of current pain education on knowledge, attitudes and perceptions of medical and nursing students, there needs to be a valid measure to assess and quantify these domains. We reviewed the literature to identify approaches for assessing knowledge, perceptions and attitudes to pain management among nursing and medical students. Methods: Databases of peer-reviewed literature including CINAHL, EMBASE, ERIC, PsycInfo, Medline and PubMed were searched for articles published between 1993 and December 2014 using the following search terms: student, graduate, intern, junior, pain, pain management, analgesia, analgesic, pharmacology, pharmacological, knowledge, competence, attitude, preparedness, practice, nursing, medical, doctor, nurse. Results: The search revealed over 3500 articles, and on application of the inclusion criteria, 26 articles were included in the review. A total of 14 instruments were used in these studies with the Knowledge and Attitudes Survey Regarding Pain (KASRP) as the main instrument in 9 out of the 26 articles. The various instruments used different question formats such as multiple-choice questions (MCQs), true/false statements and Likert scales that went from 3 points to 7 points. Clinical skills examinations were also used in four studies to assess pain management. Conclusion: There is no gold standard instrument currently used to assess knowledge, perceptions and attitudes to pain management. The results of this review showed, despite the diversity of standardised instruments that have been used to assess knowledge, perceptions and attitude to pain management, the literature has consistently reported that knowledge about pain management among nursing and medical students was generally poor among both groups.
Inducing iron deficiency improves erythropoiesis and photosensitivity in congenital erythropoietic porphyria
Authors: Egan Daniel N. , Yang Zhantao , Phillips John , Abkowitz Janis L. 
Published: May 2015

Key PointsIron deficiency results in symptom improvement in CEP and could be considered a novel therapeutic approach for this disease. CEP marrow cells demonstrated improved growth and erythroid differentiation in vitro under conditions of relative iron restriction.
von Willebrand factor fibers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans
Authors: Bauer Alexander T. , Suckau Jan , Frank Kathrin , Desch Anna , Goertz Lukas , Wagner Andreas H. , Hecker Markus , Goerge Tobias , Umansky Ludmila , Beckhove Philipp , Utikal Jochen , Gorzelanny Christian , Diaz-Valdes Nancy , Umansky Viktor , Schneider Stefan W. 
Published: May 2015

Key Points
Tumor-derived VEGF-A mediates endothelial cell activation, VWF release, and platelet aggregation provoking coagulation in tumor patients. Local ADAMTS13 inhibition promotes VWF fiber formation in tumor microvessels.
Visualizing translocation dynamics and nascent transcript errors in paused RNA polymerases in vivo
Authors: Imashimizu Masahiko , Takahashi Hiroki , Oshima Taku , McIntosh Carl , Bubunenko Mikhail , Court Donald L. , Kashlev Mikhail 
Published: May 2015

Abstract
Background
Transcription elongation is frequently interrupted by pausing signals in DNA, with downstream effects on gene expression. Transcription errors also induce prolonged pausing, which can lead to a destabilized genome by interfering with DNA replication. Mechanisms of pausing associated with translocation blocks and misincorporation have been characterized in vitro, but not in vivo.

Results
We investigate the pausing pattern of RNA polymerase (RNAP) in Escherichia coli by a novel approach, combining native elongating transcript sequencing (NET-seq) with RNase footprinting of the transcripts (RNET-seq). We reveal that the G-dC base pair at the 5′ end of the RNA-DNA hybrid interferes with RNAP translocation. The distance between the 5′ G-dC base pair and the 3′ end of RNA fluctuates over a three-nucleotide width. Thus, the G-dC base pair can induce pausing in post-translocated, pre-translocated, and backtracked states of RNAP. Additionally, a CpG sequence of the template DNA strand spanning the active site of RNAP inhibits elongation and induces G-to-A errors, which leads to backtracking of RNAP. Gre factors efficiently proofread the errors and rescue the backtracked complexes. We also find that pausing events are enriched in the 5′ untranslated region and antisense transcription of mRNA genes and are reduced in rRNA genes.

Conclusions
In E. coli, robust transcriptional pausing involves RNAP interaction with G-dC at the upstream end of the RNA-DNA hybrid, which interferes with translocation. CpG DNA sequences induce transcriptional pausing and G-to-A errors.
Associations of antibodies against citrullinated peptides with human leukocyte antigen-shared epitope and smoking prior to the development of rheumatoid arthritis
Authors: Kokkonen Heidi , Brink Mikael , Hansson Monika , Lassen Ewa , Mathsson-Alm Linda , Holmdahl Rikard , Rönnelid Johan , Klareskog Lars , Rantapää-Dahlqvist Solbritt 
Published: May 2015

Abstract
Introduction
It has previously been shown that an increased number of antibodies against citrullinated peptides/proteins (ACPA) predate the onset of rheumatoid arthritis (RA). Over time antibody positivity expands, involving more specific responses when approaching the onset of symptoms. We investigated the impact of human leukocyte antigen-shared epitope (HLA-SE) alleles and smoking on the development of ACPA, as well as in combination with ACPA during the state of quiescent autoimmunity (before the onset of symptoms), on the development of RA.

Methods
Blood samples donated to the Medical Biobank of Northern Sweden from individuals prior to the onset of symptoms of RA (n = 370) and after onset (n = 203) and from population-based controls (n = 585) were used. Antibodies against 10 citrullinated peptides, fibrinogen (Fibα561-583, α580-600, ß62-81a, ß62-81b, ß36-52), vimentin (Vim2-17, 60-75), filaggrin (CCP-1/Fil307-324), α-enolase (CEP-1/Eno5-21), collagen type II (citC1359-369), and anti-cyclic citrullinated peptide (CCP)2 antibodies were analysed.

Results
HLA-SE-positive individuals were more frequently positive for ACPA compared with HLA-SE-negative individuals prior to the onset of symptoms of RA, particularly for antibodies against CEP-1 and Fibß62-81a (72). Smoking was associated with antibodies against Vim2-17 and citC1359-369. HLA-SE and smoking showed increasing association to the presence of the antibodies closer to disease onset. The highest odds ratio (OR) for development of RA was for the combination of HLA-SE alleles and ACPA positivity, especially for antibodies against Fibß62-81b, CCP-1/Fil307-324, and Fibβ36-52. A gene-environment additive interaction between smoking and HLA-SE alleles for the risk of disease development was found, with the highest OR for individuals positive for antibodies against Fibβ36-52, CEP-1, and Fibα580-600.

Conclusions
The relationships between antibodies against the different ACPA specificities, HLA-SE, and smoking showed a variable pattern in individuals prior to the onset of RA. The combination of smoking and HLA-SE alleles was significantly associated with the development of some of the antibody specificities closer to onset of symptoms, and these associations remained significant at diagnosis. An additive gene-environment interaction was found for several of the antibodies for the development of RA.
Vibrational spectroscopy for the study of Chilean cultural heritage
Authors: Campos Marcelo M Vallette , Aguayo Tomás Alvarado 
Published: May 2015

Abstract

Background
Natural and synthetic colouring products along with its associated supporting materials have been studied in several expressions of the Chilean cultural heritage using vibrational spectroscopy. These expressions include archaeological remains as well as works of art.

Results
Among the materials studied so far we can count pigments found in archaeological sites from the north of Chile, in plaster (wall paintings) and in polychrome (beams), and dyes mainly related to added components on historic silk textiles. Identification of materials resulted to be relevant to know about Chilean culture through history.

Conclusions
The vibrational knowledge obtained contributes to give solid data as a complement to the different information aspects collected by conservation professionals involved in the characterization and conservation procedures of cultural heritage and also it gives us the opportunity to share knowledge and to give value to objects that not always are of the public domain.