bluuebunny/crossref_metadata_2025_split huggingface dataset:
Online motion synthesis using sequential Monte Carlo
Authors: Hämäläinen Perttu , Eriksson Sebastian , Tanskanen Esa , Kyrki Ville , Lehtinen Jaakko 
Published: July 2014

We present a Model-Predictive Control (MPC) system for online synthesis of interactive and physically valid character motion. Our system enables a complex (36-DOF) 3D human character model to balance in a given pose, dodge projectiles, and improvise a get up strategy if forced to lose balance, all in a dynamic and unpredictable environment. Such contact-rich, predictive and reactive motions have previously only been generated offline or using a handcrafted state machine or a dataset of reference motions, which our system does not require.
For each animation frame, our system generates trajectories of character control parameters for the near future --- a few seconds --- using Sequential Monte Carlo sampling. Our main technical contribution is a multimodal, tree-based sampler that simultaneously explores multiple different near-term control strategies represented as parameter splines. The strategies represented by each sample are evaluated in parallel using a causal physics engine. The best strategy, as determined by an objective function measuring goal achievement, fluidity of motion, etc., is used as the control signal for the current frame, but maintaining multiple hypotheses is crucial for adapting to dynamically changing environments.
A Multiple Iterated Integral Inequality and Applications
Authors: Hou Zongyi , Wang Wu-Sheng 
Published: July 2014

We establish new multiple iterated Volterra-Fredholm type integral inequalities, where the composite functionw(u(s))of the unknown functionuwith nonlinear functionwin integral functions in [Ma, QH, Pečarić, J: Estimates on solutions of some new nonlinear retarded Volterra-Fredholm type integral inequalities.Nonlinear Anal.69 (2008) 393–407] is changed into the composite functionsw1(u(s)),w2(u(s)),…, wn (u(s))of the unknown functionuwith different nonlinear functionsw1,w2,…,wn, respectively. By adopting novel analysis techniques, the upper bounds of the embedded unknown functions are estimated explicitly. The derived results can be applied in the study of solutions of ordinary differential equations and integral equations.
TGFβ Inhibition Prior to Hypofractionated Radiation Enhances Efficacy in Preclinical Models
Authors: Young Kristina H. , Newell Pippa , Cottam Benjamin , Friedman David , Savage Talicia , Baird Jason R. , Akporiaye Emmanuel , Gough Michael J. , Crittenden Marka 
Published: July 2014

AbstractThe immune infiltrate in colorectal cancer has been correlated with outcome, such that individuals with higher infiltrations of T cells have increased survival independent of the disease stage. For patients with lower immune infiltrates, overall survival is limited. Because the patients with colorectal cancer studied have received conventional cancer therapies, these data may indicate that the pretreatment tumor environment increases the efficacy of treatments such as chemotherapy, surgery, and radiotherapy. This study was designed to test the hypothesis that an improved immune environment in the tumor at the time of treatment will increase the efficacy of radiotherapy. We demonstrate that inhibition of TGFβ using the orally available small-molecule inhibitor SM16 improved the immune environment of tumors in mice and significantly improved the efficacy of subsequent radiotherapy. This effect was not due to changes in radiosensitivity, epithelial–mesenchymal transition, or changes in vascular function in the tumor; rather, this effect was dependent on adaptive immunity and resulted in long-term protective immunity in cured mice. These data demonstrate that immunotherapy is an option to improve the immune status of patients with poor tumor infiltrates and that pretreatment improves the efficacy of radiotherapy. Cancer Immunol Res; 2(10); 1011–22. ©2014 AACR.
Characterizing the Inflammatory Tissue Response to Acute Myocardial Infarction by Clinical Multimodality Noninvasive Imaging
Authors: Wollenweber Tim , Roentgen Philipp , Schäfer Andreas , Schatka Imke , Zwadlo Caroline , Brunkhorst Thomas , Berding Georg , Bauersachs Johann , Bengel Frank M. 
Published: July 2014

Background—
Myocardial infarction (MI) triggers a systemic inflammatory response which determines subsequent healing. Experimentally, cardiac positron emission tomography and magnetic resonance imaging have been used successfully to obtain mechanistic insights. We explored the translational potential in patients early after MI.

Methods and Results—

Positron emission tomography/computed tomography and cardiac magnetic resonance were performed in 15 patients <7 days after first MI. Cardiac magnetic resonance showed regional transmural late gadolinium enhancement and edema exceeding the area of late gadolinium enhancement. Using F-18 deoxyglucose with heparin pretreatment, metabolic rate of glucose (MRGlc) was significantly increased in infarct versus remote myocardium (median, 2.0 versus 0.4 mg/min per 100 mL;
P
=0.0001). MRGlc in infarct correlated with remote myocardium (ρ=0.64;
P
=0.01), spleen (ρ=0.82;
P
=0.0002), and bone marrow(ρ=0.57;
P
=0.03), but not with muscle or liver. Regionally, F-18 deoxyglucose score was highest in segments with late gadolinium enhancement versus edema only and remote (median, 2.0 versus 1.8 versus 0.4;
P
<0.0001). Patients requiring repeat intervention during preliminary follow-up of 11±5 months tended to have higher early post-MI MRGlc. Five patients with chronic, stable MI served as controls. Opposite to acute MI, MRGlc was lower in infarct (median infarct/remote ratio, 0.6 versus 3.2 for acute MI;
P
=0.001), and there was no correlation with bone marrow or spleen MRGlc.

Conclusions—
Increased glucose utilization after heparin-induced suppression of myocyte uptake appears to mostly reflect inflammatory activity in damaged myocardium early after MI. Consistent with prior preclinical observations, and in contrast to chronic MI, this is associated with activity in spleen and bone marrow as sources of inflammatory cells. Positron emission tomography and cardiac magnetic resonance multimodality characterization of the acutely infarcted, inflamed myocardium may provide multiparametric end points for clinical studies aiming at support of infarct healing.
Evolution of male and female release calls in African clawed frogs
Authors: Tobias Martha L. , Korsh Jeremy , Kelley Darcy B. 
Published: July 2014

In anurans, male clasps can elicit release calls from either sex. Male release calls have been observed in many anuran genera and this vocal response is thus highly conserved. Female release calls, however, are not as prevalent, suggesting that evolutionary trajectories for anuran release calls differ by sex. We analyzed male and female release calls in all available species of Xenopus, a fully aquatic African genus. Phylogenetic relationships in this genus include three species groups, two of which are clades and one of which is characterized by a reticulated phylogeny due in part to hybridizations between species with different ploidy levels (Evans et al., 2004; Evans, 2008). In all species, males produce release calls when clasped by another male. Females in the reticulated group do not produce release calls, but females in the rest of the genus do. Release calls consist of click trains of variable durations and inter-call intervals. In both sexes, inter-click interval divides the genus into groups with different click rates and these groups are phylogenetically related. In general, inter-click interval is shorter in male than in female release calls. Across species and sexes, release calls are characterized by a single, low (∼1000 Hz) dominant frequency. In X. laevis Congo and X. borealis, clasp duration is longer for male–female than for male–male pairs and clasp duration is correlated with the number, but not the duration, of release calls in male–male pairs. We discuss evolutionary scenarios for release call traits as well as the sex difference in occurrence.
The Future of the Past
Authors: Gabrielle M. Spiegel 
Published: July 2014

The article examines revisions to theories of “linguistic turn” historiography in order to show the ways in which those revisions have created a path for a return of the analysis of individual agency and experience in history, changes that, it is argued, constitute a form of neo-phenomenology as the governing philosophical orientation in historiography. To the extent that this is correct, it establishes a philosophical and theoretical basis for the integration of memory and memorial testimony into the study of the past.
The article proceeds to investigate the methodological, historiographical and ethical implications of the rise of memory studies in contemporary history. Memorial literature, as Berber Bevernage has so compellingly demonstrated, relies on a certain haunting of the present by the past. It thus deploys a conception of historical temporality significantly different from the modernist assumption of the death of the past as the basis of historical understanding. In that sense, as Michael Roth has argued, the “acknowledgement of the past in the present is a necessary ingredient of modern historical consciousness.” Yet, to incorporate “memory” and trauma into historical representation will mean acknowledging and accepting as historiographically viable the differing status of analytically recuperated “facts” and victim testimony. This will require, in turn, that we find a way to theorize, as has yet to be done, the materiality and reality of “voices” from the past, without assuming the necessary truth of what they convey, at least in terms of the factuality of its content. In the end, however, what is at stake in not the epistemological question of “truth” but an ethical response to the catastrophes of the last century.
At the same time, it is clear that memory is no longer the sole vehicle for the promotion of a new ethical orientation in history, as recent work by Hayden White, Keith Jenkins and Frank Ankersmit, among others, suggest. Precisely how these different approaches to history, memory and ethics can be combined to constitute a viable and coherent mode of historiography remains an open, and debated, question.
The Continuing Relevance of Speculative Philosophy of History
Authors: Fillion Réal 
Published: July 2014

Speculative philosophy of history is concerned with history as a whole, which includes explicitly relating the past to the present and the present to the future. It proposes a philosophical appreciation of the importance of history in our lives and in our self-knowledge, but where history is understood not only as revealing to us what is past, but also as a shaping of the present, which itself sets the conditions for future developments. The notion of history-as-a-whole I propose to call, for the purposes of discussion, the past-present-future complex and it is this complex that is the explicit concern of the speculative philosopher of history. The speculative philosopher of history is never far from the historian and her work, whose concern is to elucidate the past and reveal its intelligibility, and in that sense, the past remains the privileged “object” of history, precisely because the past, as past, needs to be re-presented in order to be known, and is known through its re-presentations. I will here briefly discuss Frank Ankersmit’s account of the work of representation in his recent Meaning, Truth, and Reference in Historical Representation (Ithaca: Cornell University Press, 2012).
Two things about this work of re-presentation will be noted: 1) because what is re-presented is a past reality, it provides a contrast to present reality, and 2) because the past re-presented is meant to be an account of the reality of the past, it gives us a sense of the necessity of what has been. For the speculative philosopher of history, taking these two features together raises the modal consideration of the relation between the necessity of what has come to pass (as re-presented) and the lived contingency of the present. Here I will briefly discuss the relevance of Michel Foucault’s work in relating past and present in terms of the contingent formations that shape our lives (including the histories we re-present). While Foucault’s focus on contingent formations privileges the notion of possibility within the historical field of the present, it does not systematically address how such possibility might relate to the future. For this last modal consideration, I will discuss briefly Ernst Bloch’s work, specifically the notions of Not-Yet- and What-Is- as discussed in the Principle of Hope (Cambridge: The MIT Press, 1986) as a way to address the future within the past-present-future complex that is the concern of speculative philosophy of history.
On the Recovery of 3D Spatial Statistics of Particles from 1D Measurements: Implications for Airborne Instruments
Authors: Larsen Michael L. , Briner Clarissa A. , Boehner Philip 
Published: July 2014

Abstract
The spatial positions of individual aerosol particles, cloud droplets, or raindrops can be modeled as a point processes in three dimensions. Characterization of three-dimensional point processes often involves the calculation or estimation of the radial distribution function (RDF) and/or the pair-correlation function (PCF) for the system. Sampling these three-dimensional systems is often impractical, however, and, consequently, these three-dimensional systems are directly measured by probing the system along a one-dimensional transect through the volume (e.g., an aircraft-mounted cloud probe measuring a thin horizontal “skewer” through a cloud). The measured RDF and PCF of these one-dimensional transects are related to (but not, in general, equal to) the RDF/PCF of the intrinsic three-dimensional systems from which the sample was taken. Previous work examined the formal mathematical relationship between the statistics of the intrinsic three-dimensional system and the one-dimensional transect; this study extends the previous work within the context of realistic sampling variability. Natural sampling variability is found to constrain substantially the usefulness of applying previous theoretical relationships. Implications for future sampling strategies are discussed.
A novel method for the measurement of plasma metanephrines using online solid phase extraction-liquid chromatography tandem mass spectrometry
Authors: Adaway Joanne E , Peitzsch Mirko , Keevil Brian G 
Published: July 2014

Background Measurement of plasma metanephrine, normetanephrine and 3-methoxytyramine is useful in the diagnosis of phaeochromocytomas, but many assays require a large volume of plasma due to poor assay sensitivity, and often require lengthy sample preparation. Our aim was to develop a method for measurement of plasma metanephrines using a small sample volume with minimal hands-on preparation. Methods Samples were deproteinised using 10 K spin filters prior to online solid phase extraction using a Waters Acquity UPLC Online SPE Manager (Waters, Manchester, UK) coupled to a Waters Xevo TQ-S mass spectrometer (Waters, Manchester, UK). The assay was validated and results compared to a previously published method. Results We achieved a limit of quantification of 37.5 pmol/L for metanephrine and 3-methoxytyramine and 75 pmol/L for normetanephrine using only 150  µL of sample. The assay was linear up to 30,000 pmol/L for all analytes and in a method comparison study results showed good agreement with a previously published LC-MS/MS assay. Conclusions We have developed a simple method for measurement of plasma metanephrine, normetanephrine and 3-methoxytyramine using only 150  µL of sample. There is minimal hands-on sample preparation required and the assay is suitable for routine use in a clinical laboratory.
Risk factors associated with adverse outcome following extracorporeal life support: analysis from 360 consecutive patients
Authors: Papadopoulos N , Marinos S , El-Sayed Ahmad A , Keller H , Meybohm P , Zacharowski K , Moritz A , Zierer A 
Published: July 2014

Objective: Risk factors for adverse outcome after extracorporeal life support (ECLS) are yet to be defined. For this purpose, we reviewed our institutional data from more than a decade, focusing on patients with ECLS. Methods: Between December 2001 and June 2013, 360 consecutive cardiac surgical patients received ECLS for post-cardiotomy cardiogenic shock, with high mortality risk despite optimal conventional therapy. Patient demographics, clinical characteristics, ECLS-related morbidity, as well as in-hospital and long-term mortality were analysed. Multivariate logistic regression analysis was performed to identify independent predictors of adverse outcome (failed ECLS weaning, in-hospital mortality). Results: The mean age was 62±17 years, 76% were male and the mean preoperative ejection fraction was 35±16%. ECLS was established through peripheral (90%) or central thoracic cannulation. The mean duration of ECLS was 7±1 days. Intra-aortic balloon pumps were implanted in 22% of the patients. ECLS weaning was successful in 58% and 30% could be discharged from hospital. The main cause of death was sepsis (69%). Overall, major cerebrovascular events occurred in 12% (bleeding 3%, embolic 9%), limb ischaemia in 13%, gastrointestinal complications in 16% and renal replacement therapy in 61%. Independent risk factors for adverse outcome were prior cardiorespiratory resuscitation (OR: 4.1, 95%CI: 0.34-4.21, p=0.04), pH <7.1 (OR: 2.8, 95%CI: 0.45-3.28, p=0.01), serum lactate >120 mg/dL (OR: 2.6, 95%CI: 0.75-2.96, p< 0.01), norepinephrine dosage >0.5 µg/kg/min (OR: 2.4, 95%CI: 0.35-2.92, p=0.02) and age >75 years (OR: 2.0, 95%CI: 0.41-2.88, p=0.02). Kaplan Meier estimates for long-term survival were 26±3% at one year and 22±2% at five years. Conclusion: ECLS therapy offers one-year survival to one quarter of patients with an otherwise fatal prognosis. Procedural mortality is low and morbidity at the implantation site typically moderate. Thus, prolonged metabolic deterioration in combination with high-dose vasopressor support prior to ECLS therapy should be avoided, particularly in younger patients.
Re-examining the role of benzodiazepines in the treatment of schizophrenia: A systematic review
Authors: Sim Faye , Sweetman Isabel , Kapur Shitij , Patel Maxine X 
Published: July 2014

Background Benzodiazepine prescribing for schizophrenia occurs in clinical practice and antipsychotic trials. This review examined the clinical outcomes for benzodiazepines in schizophrenia. Method A systematic search identified randomised controlled trials that evaluated benzodiazepines in comparison with placebo or antipsychotics, and also as adjuncts to antipsychotics. Relevant clinical outcome data was extracted. Results Twenty six studies were included with some reporting multiple comparisons. Seven short-term studies compared benzodiazepines with placebo: benzodiazepine superiority was found in two out of five studies for global improvements and two out of four studies for psychiatric/behavioural outcomes. Eleven studies compared benzodiazepines with first-generation antipsychotics (FGAs): four out of nine studies (including two long-term studies) reported greater global improvements for antipsychotics; four out of five studies showed no treatment differences for psychiatric/behavioural outcomes. Fourteen studies compared benzodiazepines (as adjunct to antipsychotics) vs antipsychotics alone (mostly FGAs); benzodiazepine superiority was found for global improvement in one out of eight studies and inferiority in two out of eight short-term studies whereas superiority was found for psychiatric/behavioural outcomes in three out of 12 short-term studies and inferiority in three out of 12 studies. Conclusion Benzodiazepine superiority over placebo was found for global, psychiatric and behavioural outcomes, but inferiority to antipsychotics on longer-term global outcomes. Conflicting evidence exists regarding the addition of benzodiazepines to antipsychotics; thus the use of benzodiazepines in clinical practice and antipsychotic trials should be limited.
Return to Duty After Elective Fasciotomy for Chronic Exertional Compartment Syndrome
Authors: McCallum Jeremy R. , Cook Jay B. , Hines Adam C. , Shaha James S. , Jex Jefferson W. , Orchowski Joseph R. 
Published: July 2014

Background: Civilian literature has reported excellent outcomes after elective fasciotomy for chronic exertional compartment syndrome (CECS). Our study’s purpose was to objectively investigate the functional outcome of fasciotomies performed for CECS in a high demand military population. Methods: A retrospective review of all fasciotomies performed for CECS at a single tertiary military medical center was performed. The primary outcome measure was the ability to return to full active duty. Diagnosis, operative technique, and number of compartments addressed were collected and analyzed. Patients were contacted and the visual analog scale (VAS) pain score, functional single assessment numeric evaluation (SANE) score, as well as overall satisfaction were reported. Return to duty status was collected on 70 of 70 (100%) consecutive operative extremities in 46 patients with an average follow-up of 26 months. Results: Only 19 patients (41.3%) were able to return to full active duty. Ten patients (21.7%) underwent a medical separation from the military and 17 patients (37%) remained in the military but were on restricted duty secondary to persistent leg pain. Thirty-five of 46 (76%) of the patients were contacted and provided subjective feedback. The average SANE score was 72.3, and there was a mean improvement of 4.4 points in VAS score postoperatively. Overall, 71% of patients were satisfied and would undergo the procedure again. Outcomes were correlated to operative technique, patient rank, and branch of military service. Conclusion: Our study showed a return to full military duty in 41% of patients who underwent elective fasciotomy for CECS. Overall 78% of patients remained in the military, which is consistent with previous military literature. Subjective satisfaction rate was 71%. Both the return to activity and subjective outcomes in our study population were substantially lower than reported results in civilian populations. Level of Evidence: Level IV, case series.
Novel Insulin Delivery Profiles for Mixed Meals for Sensor-Augmented Pump and Closed-Loop Artificial Pancreas Therapy for Type 1 Diabetes Mellitus
Authors: Srinivasan Asavari , Lee Joon Bok , Dassau Eyal , Doyle Francis J. 
Published: July 2014

Background: Maintaining euglycemia for people with type 1 diabetes is highly challenging, and variations in glucose absorption rates with meal composition require meal type specific insulin delivery profiles for optimal blood glucose control. Traditional basal/bolus therapy is not fully optimized for meals of varied fat contents. Thus, regimens for low- and high-fat meals were developed to improve current insulin pump therapy. Method: Simulations of meals with varied fat content demonstrably replicated published data. Subsequently, an insulin profile library with optimized delivery regimens under open and closed loop for various meal compositions was constructed using particle swarm optimization. Results: Calculations showed that the optimal basal bolus insulin profiles for low-fat meals comprise a normal bolus or a short wave. The preferred delivery for high-fat meals is typically biphasic, but can extend to multiple phases depending on meal characteristics. Results also revealed that patients that are highly sensitive to insulin could benefit from biphasic deliveries. Preliminary investigations of the optimal closed-loop regimens also display bi- or multiphasic patterns for high-fat meals. Conclusions: The novel insulin delivery profiles present new waveforms that provide better control of postprandial glucose excursions than existing schemes. Furthermore, the proposed novel regimens are also more or similarly robust to uncertainties in meal parameter estimates, with the closed-loop schemes demonstrating superior performance and robustness.