bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Anti‐Epiligrin Cicatricial Pemphigoid Associated with Lung Carcinoma and Severe Laryngeal Stenosis: Review of Japanese Cases and Evaluation of Risk for Internal Malignancy
Authors: Matsushima Satoko , Horiguchi Yuji , Honda Tetsuya , Fujii Shinobu , Okano Takayuki , Tanabe Masahiro , Wakayama Toshiaki , Hashimoto Takashi , Yancey Kim B. 
Published: July 2014

AbstractA 68‐year‐old Japanese male with a five‐year‐history of lung carcinoma showed recurrent blisters and erosions on the oral and genital mucosae and the skin. The patient complained of dyspnea due to severe laryngeal stenosis and underwent a tracheostomy. A skin biopsy specimen showed a subepidermal blister and linear deposits of IgG and C3 at the basement membrane zone of the epidermis. Indirect immunofluorescence examination demonstrated circulating IgG anti‐basement membrane zone autoantibodies that reacted to epiligrin on immunoblotting. Based on a diagnosis of anti‐epiligrin cicatricial pemphigoid, he was treated with prednisolone, minocycline hydrochloride and nicotinamide. Although no new skin lesions appeared, he died of lung carcinoma five months after the tracheostomy. A review of reported cases with anti‐epiligrin cicatricial pemphigoid in Japan disclosed that 5 of 16 cases (31.2%) were complicated by internal malignancies.
Benign Fibrous Histiocytoma of the Eyelid with an Unusual Clinical Presentation
Authors: Kargı Eksal , Kargı Şebnem , Gün Banu , Hoşnuter Mübin , Altinyazar Cevdet , Aktunç Erol 
Published: July 2014

AbstractBenign fibrous histiocytoma is a common soft tissue tumor that can be deep or superficially located. Although the deep type of fibrous histiocytoma has a predilection for the orbit, the eyelids are an unusual location for the cutaneous type. A 42‐year‐old woman had bilateral yellowish nodular masses of the eyelids for two years. Pathological examination after excision revealed benign fibrous histiocytoma. Our case is an unusual clinical presentation of cutaneous fibrous histiocytoma as well as a rare location such as the eyelids.
Swan‐Neck Deformity and Paresthesia Following Giant Orf
Authors: Uzel Murat , Sasmaz Sezai , Ozkul Aykut , Cetinus Ercan , Bilgic Erkal , Karaoguz Ahmet 
Published: July 2014

AbstractOrf is a zoonotic infection caused by a parapoxvirus that primarily infects sheep and goats. Human orf infection can take place when abraded skin comes into contact with infected animals. It occurs most commonly on the index finger. The characteristic lesion resembles a tumor and resolves spontaneously, usually without any complications. However, rare complications such as lymphangitis, adenitis, erythema multiforme, erysipelas, papulovesicular eruption, Pseudomonas aeruginosa infection, and bullous pemphigoid have been reported. Herein, we report a case of giant orf causing swan‐neck deformity and paresthesia. These complications have not been previously reported in the literature.
Delayed Development of Foreign Body Granuloma from an Implanted Permanent Cardiac Pacemaker
Authors: Kootiratrakarn Tanawatt , Kimura Yutaka , Matsunaga Jun , Tagami Hachiro 
Published: July 2014

AbstractWe report a case of a late‐developing cutaneous mass on the chest wall that proved to be non‐specific mixed cell granuloma adjacent to the lead‐electrode parts of a permanent cardiac‐pacemaker that had been implanted in the left chest of an 81‐year‐old man 6 years previously. The lesion was treated by cardiac surgeons, whose management consisted of cutting only the intradermal part of the lead‐electrodes followed by tissue curettage, leaving the other portion embedded in the subendocardium because its removal could cause serious complications. Dermatologists should be alert to such late complications of embedded permanent pacemakers. Their removal requires close cooperation with cardiac surgeons to avoid unexpected complications.
Intermittent Topical Corticosteroid/Tacrolimus Sequential Therapy Improves Lichenification and Chronic Papules More Efficiently than Intermittent Topical Corticosteroid/Emollient Sequential Therapy in Patients with Atopic Dermatitis
Authors: Nakahara Takeshi , Koga Tetsuya , Fukagawa Shuji , Uchi Hiroshi , Furue Masutaka 
Published: July 2014

AbstractAtopic dermatitis (AD) is a common, chronic, relapsing, severely pruritic, eczematous skin disease. Topical steroids are the mainstay of treatment. However, the adverse effects of steroids on hormonal function are the major obstacle for their use as long‐term topical therapy. Intermittent dosing with potent topical steroids and/or combination therapy with steroid and tacrolimus have been frequently used in the daily management of AD to overcome the problems accompanying the long term use of steroids. We compared the clinical effects of topical steroid/tacrolimus and steroid/emollient combination treatments in 17 patients with AD. An intermittent topical betamethasone butyrate propionate/tacrolimus sequential therapy improved lichenification and chronic papules of patients with AD more efficiently than an intermittent topical betamethasone butyrate propionate/emollient sequential therapy after four weeks of treatment. Only one out of 17 patients complained of a mild, but temporary, burning sensation after tacrolimus application. The intermittent topical steroid/tacrolimus sequential therapy may be a useful adjunctive treatment for AD.
Assessment of Cadexomer Iodine against Staphylococcus aureus Biofilm In vivo and In vitro Using Confocal Laser Scanning Microscopy
Authors: Akiyama Hisanori , Oono Takashi , Saito Masakazu , Iwatsuki Keiji 
Published: July 2014

AbstractCadexomer iodine releases iodine (0.9% weight/weight) slowly from beads of dextrin and epichlorhydrin. This preparation is an effective debridement and antiseptic agent for chronic exdudative wounds. The purpose of the present study is to examine the influence of cadexomer iodine against glycocalyx production of Staphylococcus aureus isolated from furuncle lesions on cut wounds in mice using confocal laser scanning microscope (CLSM), and the increase in and glycocalyx production of S. aureus in vitro. In the present study, distinct S. aureus cells and glycocalyx were not detected in the dermis around the cadexomer iodine beads or within those beads, while S. aureus cells encircled by glycocalyx were soaked up by the cadexomer beads and were detected within them in vivo and in vitro. We suggest that cadexomer iodine soaks up S. aureus cells encircled by glycocalyx, directly destroys biofilm structures, and collapses glycocalyx during dehydration, and further, that iodine can subsequently kill S. aureus cells within biofilm. Cadexomer iodine is a promising treatment to clear S. aureus cells within biofilm from skin lesions of exudative or infectious wounds and to prevent wound exacerbation.
A Case of Generalized Hair Follicle Hamartoma Associated with Systemic Lupus Erythematosus
Authors: Tsuru Kenta , Ohashi Akiko , Ueda Masato 
Published: July 2014

AbstractA hair‐follicle hamartoma (HFH) may be localized or diffuse. Generalized HFH is frequently associated with an autoimmune disease such as myasthenia gravis or systemic lupus erythematosus (SLE). We report here a female patient with SLE who developed typical generalized HFH. This is the fourth case of generalized HFH associated with SLE.
The Clinical Importance of Demodex folliculorum Presenting with Nonspecific Facial Signs and Symptoms
Authors: Karincaoglu Yelda , Bayram Nalan , Aycan Ozlem , Esrefoglu Muammer 
Published: July 2014

AbstractDemodex folliculorum (D. folliculorum), found in the pilosebaceous unit, is the most common ectoparasite of humans. Various clinical forms such as pustular folliculitis, papulopustular scalp eruptions, perioral dermatitis, and blepharitis have been defined, although in general, the disease has been classified into three main groups as “pityriasis folliculitis”, “rosacea‐like demodicidosis”, and granulomatous rosacea‐like“demodicidosis gravis”. Our aim was to test for the presence of D. folliculorum in pathogenic numbers in patients who came to our clinic with non‐specific symptoms such as facial itching with or without erythema, seborrheic dermatitis‐like or perioral dermatitis‐like lesions, papulopustular lesions, and an acneiform clinical appearance without telengiectasia or flushing. Twenty‐eight (87.5%) female and 4 male (12.5%), patients and 33 age‐and‐sex matched healthy subjects enrolled in this study. D. folliculorum was sought in the lesion sites using the noninvasive method known as the Standardised Skin Surface Biopsy (SSSB). The discovery of more than five parasites in an area of 1 cm2, was evaluated as pathogenic. For treatment, 5% permethrine cream was applied twice daily for 15 to 30 days. The clinical symptoms of the patients were classified into clinical groups and evaluated as facial itching in 2 (6.3%), nonspecific erythema and itching in 21 (65.6%), erythema and pityriasiform squamous lesions in 3 (9.4%), acneiform in 3 (9.4%), papulopustular lesions in 1 (3.1%), granulomatous rosacea‐like in 1 (3.1%), and perioral dermatitis‐like symptoms in 1 (3.3%), D. folliculorum density was determined as 5>D/cm2 in all clinical lesions. A significant clinical healing and density of D. folliculorum at <=5 D/cm2 was determined in all but two patients after treatment. We consider that D. folliculorum presentation with different symptoms and signs than classical forms is not rare. For this reason, we suggest that it is useful to test for D. folliculorum in patients with non‐classical presentations like facial itching, itching accompanied by non‐specific erythema, itching and non‐specific pityriasiform squamous lesions, and acneiform lesions.
Cutaneous Ulcerations Following Subcutaneous Interferon β Injection to a Patient with Multiple Sclerosis
Authors: Inafuku Hisashi , Khan Mohammed Abul Kasem , Nagata Tomoko , Nonaka Shigeo 
Published: July 2014

AbstractWe report a case treated with interferon beta‐1b for multiple sclerosis (MS), who developed severe cutaneous ulcers after six months of therapy. Interferon beta‐1b had been used in a regimen of 8 million IU administered subcutaneously through oblique direction of the needle, twice a week. The cutaneous ulcers developed at inoculation sites, as a result of penetration of interferon beta into dermis. Other underlying diseases of coagulative or bleeding disorders or secondary infection were excluded. Histological features of non‐specific inflammatory reactions including hyperplastic changes of blood vessels without any evidence of vasculitis were the prominent features in this case. Corticosteroid and interferon beta‐1b therapy was continued on restricted sites on the extremities with care not to repeat injections at the same sites previously used. The administration of interferon beta into subcutaneous fatty tissues vertically reduced the incidence of dermal penetration of drug and occurrence of ulcerations in this patient. We review other case reports of severe cutaneous reactions associated with interferon beta‐1b therapy in MS patients and conclude that local cytokine‐mediated, adverse, immune reaction or non‐specific cutaneous inflammatory reaction to interferon beta‐1b initiated the skin ulceration long after institution of therapy at the injection sites, and the reaction might be related to the depth of injection.
The Characteristics of Patients with Atopic Dermatitis Demonstrating a Positive Reaction in a Scratch Test after 48 Hours against House Dust Mite Antigen
Authors: Katoh Norito , Hirano Shinya , Suehiro Mitsuhiro , Masuda Kouji , Kishimoto Saburo 
Published: July 2014

AbstractThe clinical characteristics of patients in whom an IgE‐mediated reaction against house dust mite (HDM) antigens that contribute to the pathogenesis of atopic dermatitis (AD) remain unclear. This study attempted to elucidate the characteristics of patients who exhibit a positive reaction 48 hr or later against HDM in scratch tests. The reactions after epicutaneous application of the allergen to skin with prior scratching were observed for one week in sixteen AD patients showing positive immediate‐type hypersensitivity reactions for HDM. Fifty percent of the patients demonstrated positive reactions at 48 hours after epicutaneous application of HDM. Significantly higher values were demonstrated in the group positive for HDM after 48 h in serum total IgE, specific IgE for Der f1, and lactate dehydrogenase, peripheral eosinophil counts, eruption score, and the area of eruption than in the group negative for HDM after 48 h. Domestic exposure to Der f1 was also higher in the group positive for HDM after 48 h than in the negative group. These results indicate that the patients in whom the HDM‐induced reaction continuing more than 48 h and contributing to their real eczematous eruptions are characterized by considerably increased levels of specific IgE for HDM antigens, high disease activity in AD, and increased exposure to domestic HDM.
Acquired Dermal Melanocytosis: A Case with Conjunctival and Gingival Pigmentation
Authors: Wang Wenqing , Fujiwara Sakuhei , Seguchi Shun‐ichiro , Yokoyama Shigeo , Mizoguchi Masako 
Published: July 2014

AbstractA 28‐year‐old Japanese woman was referred to us because of widespread bilateral blue‐gray and brown pigmentation on her face. Pigmentation was apparant on both sclerae, the alae of the nose, the lower lip and the gingiva; and it was also evident on her extremities. A biopsy specimen revealed melanin‐containing cells and numerous mononulear cells in the upper dermis, particularly, near the small vessels. The melanin‐containing cells immunoreacted with S100‐specific antibodies but did not react with CD68‐specific antibodies, these observations indicated that they were melanocytes. A diagnosis was made of acquired dermal melanocytosis (ADM), even though ADM is very rarely associated with conjunctival and mucosal involvement. Dermal melanocytes and large numbers of mononuclear cells adjacent to small vessels in the upper dermis have not previously been reported in ADM. Such melanocytes might play an important role in protecting blood cells from ultraviolet light. The presence of mononuclear cells close to melanocytes suggests that an inflammatory reaction might have initiated the activation of these dermal melanocytes.
Pigmentation: A Potential Cutaneous Marker for AIDS?
Authors: Grover Chander , Kubba Samir , Bansal Shikha , Nanda Soni , Reddy Belum Siva Nagi 
Published: July 2014

AbstractPigmentation of skin, nails and mucosae has frequently been described in HIV positive patients. Various causes for this phenomenon have been ascribed, which include intake of various drugs like zidovudine, opportunistic infections like toxoplasmosis and adrenocortical suppression. However, there has been no uniform explanation. We describe three AIDS patients with different personal and disease profiles but essentially the same pattern of pigmentation. This pattern of pigmentation is thereby discussed. We also propose that this pigmentation could be a result of late stage HIV disease per se and thus could serve as a useful cutaneous marker for the same.
Prurigo Pigmentosa in a Patient with Primary Biliary Cirrhosis and Sjögren Syndrome
Authors: Togawa Yaei , Shinkai Hiroshi , Utani Atsushi 
Published: July 2014

AbstractA 44‐year‐old Japanese woman suddenly developed severely pruritic erythematous papules on her trunk in a symmetrical distribution. Biopsy specimens showed the typical histopathological findings of prurigo pigmentosa. She had had recurrent episodes of high fever spikes for several years, and lost 10 kg in the last year. She was diagnosed as primary biliary cirrhosis (PBC) associated with subclinical Sjögren syndrome (SjS). Predonisolone (60 mg/day) for two weeks was effective for the PBC and fever, but not for the prurigo pigmentosa. PBC may be involved in the pathogenesis of this rare skin disease.
Oxidative Stress‐Mediated Skin Damage in an Experimental Mobile Phone Model Can Be Prevented by Melatonin
Authors: Ayata Ali , Mollaoglu Hakan , Yilmaz H. Ramazan , Akturk Onur , Ozguner Fehmi , Altuntas Irfan 
Published: July 2014

AbstractMost mobile phones emit 900 MHz of radiation that is mainly absorbed by the external organs. The effects of 900 MHz of radiation on fibrosis, lipid peroxidation, and antioxidant enzymes and the ameliorating effects of melatonin (Mel) were evaluated in rat skin. Thirty Wistar‐Albino rats were used in the study. The experimental groups were the control group, the irradiated group (IR), and the irradiated+Mel treated group (IR+Mel). A dose of 900 MHz, 2 W radiation was applied to the IR group every day for 10 days (30 min/day). The IR+Mel group received 10 mg/kg/day melatonin in tap water for 10 days before the irradiation. At the end of the 10th day, a skin specimen was excised from the thoracoabdominal area. The levels of malondialdehyde (MDA) and hydroxypyroline and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), and catalase (CAT) were studied in the skin samples. MDA and hydroxyproline levels and activities of CAT and GSH‐Px were increased significantly in the IR group compared to the control group (p<0.05) and decreased significantly in the IR+Mel group (p<0.05). SOD activity was decreased significantly in the IR group and this decrease was not prevented by the Mel treatment. These results suggest that rats irradiated with 900 MHz suffer from increased fibrosis and lipid peroxidation (LPO). Mel treatment can reduce the fibrosis and LPO caused by radiation.
Angiotropic B‐Cell Lymphoma with Telangiectasia, Accompanied by Panniculitic Formation
Authors: Nishiyama Hiromi , Tanei Ryoji , Motegi Takashi , Ohta Masatsugu , Sawabe Motoji 
Published: July 2014

AbstractA 67‐year‐old female presented with diffuse edema, generalized telangiectasia, and indurated skin plaques. Histopathological findings of the skin lesion included CD45+/CD79+/CD20+ large lymphoma cells that filled the vascular lumina and infiltrated the subcutaneous tissues with panniculitic formations. Three cycles of a CHOP (cyclophosphamide, adriamycin, vincristine, and prednisolone) chemotherapy regimen resolved the skin manifestations. After five cycles of CHOP, however, she developed dementia‐like symptoms. Three cycles of additional intrathecal chemotherapy (methotrexate, cytarabine and prednisolone) did not improve the neurological symptoms.
A Case of Systemic Osteomyelitides Due to Mycobacterium avium
Authors: Yamashita Toshiharu , Endo Takao , Hamamoto Yasuo , Akiba Hidenari , Ono Ichiro , Jimbow Kowichi 
Published: July 2014

AbstractA case of multiple osteomyelitides due to Mycobacterium avium (M. avium) infection with osteosclerotic bone lesions is reported. A 67‐year‐old male had been suffering from persistent fever and back pain since October 1999, and 20.0–2.5 mg prednisolone per day was prescribed for continuous inflammatory symptoms in January 2000. Six months later, computed tomography revealed osteosclerotic lesions in the left femur and thoracic vertebrae, but no skin lesion associated with mastocytosis or internal malignancy was identified. In September of 2002, a dome‐shaped, soft subcutaneous tumor developed on the upper sternum. Histopathological findings revealed subcutaneous adipose tissue with several foci of tiny abscesses. Two weeks later, creamy pus was discharged through a draining sinus at the center of the wound. M. avium was demonstrated in the pus by Zeel‐Nielsen staining and microplate hybridization.
Metaplastic Ossification in a Cutaneous Pyogenic Granuloma: A Case Report
Authors: Kim Eun Sung , Kim Kyoung Jin , Chang Sung Eun , Lee Mi Woo , Choi Jee Ho , Moon Kee Chan , Koh Jai Kyoung 
Published: July 2014

AbstractCutaneous ossification may occur in association with a variety of cutaneous neoplasms and inflammatory conditions, such as pilomatricomas, basal cell carcinomas, nevi, chondroid syringomas, venous stasis, and scars. However, it has rarely been reported in pyogenic granuloma, a relatively common benign vascular tumor of the skin and mucous membranes. We herein presented a rare case of cutaneous pyogenic granuloma with ectopic ossification on the big toe of a 37‐year‐old man, with high recurrence despite repeated CO2 laser ablations. We propose the hypothesis that vascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMPs) play pathologic roles in the development of ectopic bone formation in pyogenic granuloma.
Elastin Gene Expression in Blepharochalasis
Authors: Kaneoya Kyoko , Momota Yutaka , Hatamochi Atsushi , Matsumoto Fumiaki , Arima Yaeno , Miyachi Yoshiki , Shinkai Hiroshi , Utani Atsushi 
Published: July 2014

AbstractBlepharochalasis is a rare condition characterized by recurrent episodes of eyelid edema lead to an atrophic eyelid skin with fine wrinkles and peculiar bronze discoloration. A 32‐year‐old female presented with loose and redundant skin of the bilateral eyelids. We diagnosed her disease as blepharochalasis by clinical features and by disappearance of elastic fibers from the dermis in the biopsied specimen. Because elastic fibers diminish in the late phase of blepharochalasis, we performed RT‐PCR to analyze the mRNA expression of elastin, a major component of elastic fiber. Elastin mRNA expression in the patient's cultured fibroblasts had not decreased compared with that in the control fibroblasts. This result suggests that environmental factors or other matrix components of elastic fibers may be involved in the loss of elastic fiber.
Impaired Contact Hypersensitivity Reaction and Reduced Production of Vascular Endothelial Growth Factor in Tumor Necrosis Factor‐α Gene‐Deficient Mice
Authors: Shibata Mari , Sueki Hirohiko , Suzuki Hirotake , Watanabe Hideaki , Ohtaki Hirokazu , Shioda Seiji , Nakanishi‐Ueda Takako , Yasuhara Hajime , Sekikawa Kenji , Iijima Masafumi 
Published: July 2014

AbstractTumor necrosis factor (TNF)‐α is an important proinflammatory cytokine in contact hypersensitivity (CHS) reactions. Previous efforts to assay CHS in TNF‐α gene‐deficient (‐/‐) mice have demonstrated a significant reduction in ear skin weight at 24 h following challenge by oxazolone, although the mechanisms of this suppression have not been examined. To further characterize the impaired CHS during evolution of the elicitation phase in TNF‐α ‐/‐ mice and to clarify its mechanisms, focusing on the roles of TNF‐α and vascular endothelial growth factor (VEGF), we used an established method of CHS assay‐sensitization and challenge by trinitrochlorobenzene (TNCB)‐ in TNF‐α ‐/‐ and wild‐type mice. We compared the histopathology of the sequential evolution of CHS between the two groups of mice and assessed both the extent of inflammatory cell infiltration and the degree of dilatation in dermal vessels labeled with CD31. We quantified the production of VEGF in the epidermis at specific time points by using a murine VEGF ELISA kit. The CHS reaction was markedly suppressed in TNF‐α ‐/‐ mice at all time points of the elicitation phase. Histologically, in TNF‐α ‐/‐ mice we observed diminished vascular permeability, reduced numbers of infiltrating inflammatory cells, neutrophils at 12 h, mononuclear cells and eosinophils at 24 h, and a decreased area of dilatation of vessels labeled with CD31. The level of epidermal VEGF in wild type mice increased rapidly after challenge and peaked at 24 h, paralleling the peak of ear swelling. In contrast, the peak level of epidermal VEGF in TNF‐α ‐/‐ mice was significantly reduced. These results suggest that TNF‐α plays an enhancing role in the elicitation phase of the CHS reaction. Diminished degrees of vascular permeability, dilatation of CD31+ vessels, and inflammatory cell infiltration in TNF‐α ‐/‐ mice are likely to be the result of a lack of TNF‐α and reduced production of epidermal VEGF.