bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delivery of Mental Health Services in Bhutan: Challenges and Way Forward
Authors: Gyeltshen Kelzang , Chhetri Bikram , Gyeltshen Dawa 
Published: July 2024

ABSTRACTBhutan is known for its developmental philosophy of Gross National Happiness. Bhutan introduced mental health services in 1997 with the launch of Mental Health Program. Mental health includes psychological, emotional, and social well‐being. The Department of Psychiatry, Jigme Dorji Wangchuck National Referral Hospital in the capital city Thimphu is the only psychiatric unit providing specialized mental health services in Bhutan. The psychiatric unit consists of multidisciplinary team rendering both out‐ and in‐patient mental health services. However, mental health services were gradually integrated in district hospitals, Primary Healthcare Centres and in schools. Although mental health services are an essential component of the healthcare system, the system faces numerous difficulties. Inaccessibility to mental health services due to geographical location and inadequate mental health professionals poses challenges in addressing mental health issues. Mental health issues are perceived differently, and the people with mental health issues often suffer from stigmatization creating barriers in seeking mental health services. Therefore, misconception and stigma associated to mental illness also cause greater challenges in delivering mental health services. Mental health funding has been substantially lower than the World Health Organization recommended mental health budget, amounting to 1% of health budget. Inadequate mental health funding remained a serious concern for the last few decades. Adequate mental health funding is vital in expanding the overall Mental Health Program and improving both the quality and quantity of mental health professionals. Additionally, enhancing community mental health initiatives will reinforce mental health services. Furthermore, there is a need for advancements in evidence and mental health research to support evidence‐based practices and enhance mental health literacy.
Efficacy of aspirin for prevention of preeclampsia in twin pregnancy: A meta‐analysis
Authors: Elhalag Rowan H. , Chèbl Pensée , Abowafia Marwan , Mohamed Mai Saad , Moussa Momen Hassan , Ghali Paula , Abdelwahab Abdelrhaman M. , Alboji Shadi , Abourady Youmna , Shah Jaffer , Motawea Karam R. 
Published: July 2024

AbstractBackgroundAspirin has been proven to be effective in preventing preeclampsia (PE) in singleton pregnancies. However, the use of aspirin for women with twin pregnancies is still debatable. The purpose of our meta‐analysis is to evaluate the effectiveness of aspirin for preventing preeclampsia in twin pregnancies.MethodsWe searched the following databases: PubMed, Scopus, Cochrane Library and Web of Science. Twelve studies were included in the meta‐analysis. The quality assessment and ROB were executed using NOS and ROB 2 respectively. RevMan software 5.4 was used for performing the analysis.ResultsThe pooled analysis showed no significant difference between the administration of aspirin and the control group in decreased incidence of PE, hypertensive disorders, IUGR or twin‐to‐twin discordance (RR = 0.73, CI = 0.43–1.24, p = 0.24), (RR = 0.60, CI = 0.34–1.07, p = 0.08), (RR = 0.90, CI = 0.45–1.82, p = 0.77) and (RR = 1.76, CI = 0.83–3.73, p = 0.14), respectively. However, the pooled analysis showed a statistically significant association between aspirin and decreased incidence of preterm birth (PTB) (RR = 0.58, CI = 0.39–0.86, p = 0.006). Subgroup analysis of the dose revealed a significant association between 100 mg of aspirin and decreased PE incidence compared with the control group (RR = 0.44, CI = 0.23–0.84, p = 0.01).ConclusionThe overall analysis showed no significant role of Aspirin in reducing the incidence of PE. The dose subgroup analysis revealed that only 100 mg of Aspirin is effective in decreasing PE. Future multicentre randomized control trials are warranted to give us conclusive results.
Computational Insights into Enzyme‐Substrate Binding Interplay Exhibit Variable Binding Attributes: A Framework for Implementing Oxidoreductase‐Based Applications
Authors: Kumar Singh Anil , Kumar Katari Sudheer , Umamaheswari Amineni , Ahmad Imran , Ali Amena , Barkat Abul , Ali Abuzer , Siddiqui Sahabjada 
Published: July 2024

AbstractLaccase (LAC) is a potent multicopper oxidase that relies on O2 for its catalytic activity. LAC has been affirmed as an environmentally friendly biocatalyst that often catalyzes a wide array of phenolic substrates. Bacterial‐derived LACs have been less investigated for non‐phenolic substrates in contrast to fungi‐derived LAC. To comprehend the substrates (3,4‐Dimethoxybenzyl alcohol, and Dimer (Guaiacyl 4‐O‐5 guaiacyl) binding interactions of LAC (Thermus thermophilus HB27) was carried out and contrasted with fungal‐derived Lignin peroxidase (LiP) (Trametes cervina) exploiting computational methods, including physicochemical properties, Sequence Annotated by Structure (SAS), Extra precision docking (Glide), and DESMOND‐directed MD‐ simulation. Protein structures exhibited by LAC, and LiP have diverse dissimilar component architects. The XP docking suggested LiP‐Dimer seems to have a comparatively lowest binding affinity (−8.413 kcal/mol), with an MMGBSA score of −33.249 kcal/mol. Further, docked complexes were validated leveraging 50 ns NPT system‐based MD‐simulation for structural and functional stability. The system achieved equilibrium and stability at the end of the simulation, with only the LiP‐3,4‐Dimethoxybenzyl alcohol complex maintained stability. The results of this study offer a framework for improving the binding ability of substrates by way of the use of in‐silico protein engineering, which might eventually result in more effective catalytic applications.
Rational Design Strategy for High‐Valence Metal‐Driven Electronically Modulated High‐Entropy Co–Ni–Fe–Cu–Mo (Oxy)Hydroxide as Superior Multifunctional Electrocatalysts
Authors: Khan Imran , Khan Salman , Alwan Basem Al , Jery Atef El , Shayan Muhammad , Wang Shiliang , Hassan Sibt ul , Rizwan Muhammad 
Published: July 2024

AbstractCreating durable and efficient multifunctional electrocatalysts capable of high current densities at low applied potentials is crucial for widespread industrial use in hydrogen production. Herein, a Co–Ni–Fe–Cu–Mo (oxy)hydroxide electrocatalyst with abundant grain boundaries on nickel foam using a scalable coating method followed by chemical precipitation is synthesized. This technique efficiently organizes hierarchical Co–Ni–Fe–Cu–Mo (oxy)hydroxide nanoparticles within ultrafine crystalline regions (<4 nm), enriched with numerous grain boundaries, enhancing catalytic site density and facilitating charge and mass transfer. The resulting catalyst, structured into nanosheets enriched with grain boundaries, exhibits superior electrocatalytic activity. It achieves a reduced overpotential of 199 mV at 10 mA cm2 current density with a Tafel slope of 48.8 mV dec1 in a 1 m KOH solution, maintaining stability over 72 h. Advanced analytical techniques reveal that incorporating high‐valency copper and molybdenum elements significantly enhances lattice oxygen activation, attributed to weakened metal–oxygen bonds facilitating the lattice oxygen mechanism (LOM). Synchrotron radiation studies confirm a synergistic interaction among constituent elements. Furthermore, the developed high‐entropy electrode demonstrates exceptional long‐term stability under high current density in alkaline environments, showcasing the effectiveness of high‐entropy strategies in advancing electrocatalytic materials for energy‐related applications.
Flexible Hydrazone‐Linked Metal‐Covalent Organic Frameworks with Copper Clusters for Efficient Electrocatalytic Oxygen Evolution Reaction
Authors: Lin Chao , Ma Huayun , He Jun‐Ru , Xu Qing , Song Meng , Cui Cheng‐Xing , Chen Yong , Li Chun‐Xiang , Jiao Mingli , Zhai Lipeng 
Published: July 2024

AbstractDespite the challenges associated with the synthesis of flexible metal‐covalent organic frameworks (MCOFs), these offer the unique advantage of maximizing the atomic utilization efficiency. However, the construction of flexible MCOFs with flexible building units or linkages has rarely been reported. In this study, novel flexible MCOFs are constructed using flexible building blocks and copper clusters with hydrazone linkages. The heterometallic frameworks (Cu, Co) are prepared through the hydrazone linkage coordination method and evaluated as catalysts for the oxygen evolution reaction (OER). Owing to the spatial separation and functional cooperation of the heterometallic MCOF catalysts, the as‐synthesized MCOFs exhibited outstanding catalytic activities with an overpotential of 268.8 mV at 10 mA cm–2 for the OER in 1 M KOH, which is superior to those of the reported covalent organic frameworks (COFs)‐based OER catalysts. Theoretical calculations further elucidated the synergistic effect of heterometallic active sites within the linkages and frameworks, contributing to the enhanced OER activity. This study thus introduces a novel approach to the fundamental design of flexible MCOF catalysts for the OER, emphasizing their enhanced atomic utilization efficiency.
Rapidly Prepared Lithophilic Frameworks Stabilizes Lithium Anodes via Altered Lithium Deposition Patterns
Authors: Cai Weiming , Gao Yuancan , Feng Wei , Xu Junwei , Wang Meng , Sun Jiale , Cao Mengxue , Qu Zhongqing , Liu Xuying , Huang Xia , Zhou Haihui , Huang Zhongyuan 
Published: July 2024

AbstractLithium metal batteries are regarded as promising candidates for next‐generation energy storage systems. However, their anodes are susceptible to interfacial instability due to significant volume changes, which significantly impacts the cycle life of lithium metal batteries. Here, a rapid method for the fabrication of 3D‐hosts with interface modified layers is reported. A simple infiltration and heating process enables the transformation of copper foam into Zn‐BDC‐modified copper foam within 1 min, rendering it suitable for use as a current collector for lithium metal anodes. The Zn‐BDC nanosheets with high lithiophilicity are uniformly distributed on the surface of the current collector, facilitating the uniform deposition of lithium and reducing the volume change. Consequently, the half cell exhibits a remarkably low overpotential (26 mV) at a current–density of 4 mA cm−2 and is cycled stably for 1000 h. Furthermore, it demonstrates a significant enhancement in performance in the LiFePO4 full cell. This study provides a crucial reference on the connection between the interfacial modification of the current collector and the lithium deposition behavior, which promotes the practicalization of lithium metal anodes.
Scalable Cathodic H2O2 Electrosynthesis using Cobalt‐Coordinated Nanocellulose Electrocatalyst
Authors: Qian Zhiyun , Liu Di , Liu Detao , Luo Yao , Ji Wenhao , Wang Yan , Chen Yonghao , Hu Rui , Pan Hui , Wu Peilin , Duan Yulong 
Published: July 2024

AbstractConverting hierarchical biomass structure into cutting‐edge architecture of electrocatalysts can effectively relieve the extreme dependency of nonrenewable fossil‐fuel‐resources typically suffering from low cost‐effectiveness, scarce supplies, and adverse environmental impacts. A cost‐effective cobalt‐coordinated nanocellulose (CNF) strategy is reported for realizing a high‐performance 2e‐ORR electrocatalysts through molecular engineering of hybrid ZIFs‐CNF architecture. By a coordination and pyrolysis process, it generates substantial oxygen‐capturing active sites within the typically oxygen‐insulating cellulose, promoting O2 mass and electron transfer efficiency along the nanostructured Co3O4 anchored with CNF‐based biochar. The Co‐CNF electrocatalyst exhibits an exceptional H2O2 electrosynthesis efficiency of ≈510.58 mg L−1 cm−2 h−1 with an exceptional superiority over the existing biochar‐, or fossil‐fuel‐derived electrocatalysts. The combination of the electrocatalysts with stainless steel mesh serving as a dual cathode can strongly decompose regular organic pollutants (up to 99.43% removal efficiency by 30 min), showing to be a desirable approach for clean environmental remediation with sustainability, ecological safety, and high‐performance.
Gastric Cancer Assembloids Derived from Patient‐Derived Xenografts: A Preclinical Model for Therapeutic Drug Screening
Authors: Xu Xinxin , Gao Yunhe , Dai Jianli , Wang Qianqian , Wang Zixuan , Liang Wenquan , Zhang Qing , Ma Wenbo , Liu Zibo , Luo Hao , Qiao Zhi , Li Li , Wang Zijian , Chen Lin , Zhang Yanmei , Xiong Zhuo 
Published: July 2024

AbstractThe construction of reliable preclinical models is crucial for understanding the molecular mechanisms involved in gastric cancer and for advancing precision medicine. Currently, existing in vitro tumor models often do not accurately replicate the human gastric cancer environment and are unsuitable for high‐throughput therapeutic drug screening. In this study, droplet microfluidic technology is employed to create novel gastric cancer assembloids by encapsulating patient‐derived xenograft gastric cancer cells and patient stromal cells in Gelatin methacryloyl (GelMA)‐Gelatin‐Matrigel microgels. The usage of GelMA‐Gelatin‐Matrigel composite hydrogel effectively alleviated cell aggregation and sedimentation during the assembly process, allowing for the handling of large volumes of cell‐laden hydrogel and the uniform generation of assembloids in a high‐throughput manner. Notably, the patient‐derived xenograft assembloids exhibited high consistency with primary tumors at both transcriptomic and histological levels, and can be efficiently scaled up for preclinical drug screening efforts. Furthermore, the drug screening results clearly demonstrated that the in vitro assembloid model closely mirrored in vivo drug responses. Thus, these findings suggest that gastric cancer assembloids, which effectively replicate the in vivo tumor microenvironment, show promise for enabling more precise high‐throughput drug screening and predicting the clinical outcomes of various drugs.
3D Porous Fibers with Spatial Traps and Excellent Zn2+ Transport Kinetics Enable Stable Zn‐Based Aqueous Battery
Authors: Chen Xiang , Chen Yuting , Li Yuanyuan , Guo Can , Pu Jun , Liu Yang , Li Xiaoge , Yao Yagang , Gong Wenbin , Xue Pan , Han Jie 
Published: July 2024

AbstractAdverse side reactions and uncontrolled Zn dendrites growth are the dominant factors that have restricted the application of Zn ion batteries. Herein, a 3D self‐supporting porous carbon fibers (denoted as PCFs) host is developed with “trap” effect to adjust the Zn deposition. The unique open structural design of N‐doped carbon can act as the zincophilic sites to induce uniform deposition and inhibit adverse side reactions. More importantly, the porous hollow PCFs host with “trap” effect can induce Zn deposition in the fiber by adjusting the local electric field and current density, thereby increasing the specific energy density of the battery and inhibiting dendrite growth. In addition, the 3D open frameworks can regulate Zn2+ flux to enable outstanding cycling performance at ultra‐high current densities. As expected, the PCFs framework guarantees the uniform Zn plating and stripping with an outstanding stability over 6000 cycles at the current density of 40 mA cm−2. And the Zn@PCFs||MnO2 full battery shows an excellent lifespan over 1300 cycles at 2000 mA g−1.
Effect of Different Calcium and Magnesium Treatments on the Evolution of Nonmetallic Inclusions in AH36 Ship Plate Steel
Authors: Wu Ting , Peng Chun‐Lin , Kong Hui , Kang Lei , Cheng Xiang , Zhang Peng , Qiu Yue 
Published: July 2024

Comprehensive thermodynamic calculations and high‐temperature experiments are performed to systematically evaluate the effect of calcium and magnesium additions on the modification and control of inclusions in AH36 ship plate steel. The results show that Al2O3 or MgAl2O4 inclusions are formed under the casting temperature conditions. Calcium treatment modifies the inclusions into calcium aluminate, of which components partially fall into the liquidus region, and the aspect ratio and number density of inclusions became smaller, avoiding nozzle clogging, but the inclusions are easy to gather and grow up, which would affect the steel properties. Magnesium treatment modifies the inclusions into dispersed magnesium‐aluminum spinel with small size. However, the number density and aspect ratio of inclusions increase, as well as the melting points of inclusions are high, which would easily cause nozzle clogging. When calcium–magnesium synergistic treatment, with the increase of magnesium proportion, the inclusions types increased, and the liquidus area of inclusions became narrower until it disappeared. Synergistic treatment with more calcium and less magnesium (Ca2Mg1) is optimal since the inclusions were fine and diffuse, and the corresponding liquidus area of inclusions is wider than the calcium treatment.
Measuring dynamic supply chain risks for the offshoring decision in the post‐COVID‐19 era: A longitudinal study
Authors: Min Hokey , Ahn Young‐Hyo , Ma Jin‐Hee 
Published: July 2024

AbstractIn times of prolonged economic doldrums across the globe, multinational firms (MNFs) offshoring blunders can undermine their competitiveness in the marketplace. To help the MNF formulate a more resilient offshoring strategy and identify the most desirable offshoring destination, this article aims to identify dynamic risk factors that significantly hinder the efficiency of offshoring and then measure specific offshoring risks over time using two different versions of data envelopment analysis (DEA) models and Malmquist productivity index (MPI). After assessing the degree of risk resiliency of the offshoring host countries over extended periods and then conducting Tobit regression analysis to identify key factors that significantly influence offshoring risks, we found that the host country's logistics efficiency (i.e., logistics performance index [LPI]) and domestic market size were critical indicators of offshoring success in that country. Since low‐cost sourcing countries (LCCs) tend to have relatively low LPIs and smaller domestic market sizes, they are not attractive offshoring destinations. This finding defies conventional wisdom. This article is one of the first longitudinal studies to assess the comprehensive risk resilience of 87 different offshoring destinations (countries) during multiple periods (6‐year span).
Methacrylic acid grafted inulin and carboxymethyl cellulose as additives in the development of pH sensitive hydrogel matrix for colon targeting
Authors: Dutta Pallobi , Mukherjee Kaushik , Giri Tapan Kumar 
Published: July 2024

AbstractCompression‐coated matrix tablets were developed to target budesonide (BUD) in the colonic region using methacrylic acid (MAA) grafted inulin (INU) and carboxymethyl cellulose (CMC). INU was grafted with MAA to impart anionic characteristics to the gum, making it feasible to form a hydrogel by cross‐linking with calcium gluconate (CG). The core matrix made up of MAA‐g‐INU alone disintegrated within 30 min and the core matrix made up of CMC alone completely released BUD within 6 h. The combination of MAA‐g‐INU and CMC produced a rigid matrix, which was able to completely release BUD after 7 h. Compression coating of the core tablets with MAA‐g‐INU and CMC did not release BUD in the first 4 h, and complete BUD release took place in the next 4 h. Compression coating led to the formation of a rigid and viscous gel layer outside the core matrices, which hindered BUD release. We conclude that compression coating with CG cross‐linked CMC and MAA‐g‐INU could be used as a matrix for colonic delivery of drugs.Highlights
Compression coated matrices were developed for colonic delivery of BUD.
The matrix retained drug release up to 4 h in upper gastrointestinal tract (GIT).
The matrix exhibited complete drug release in the next 4 h in the colon.
A simple infiltrometer automated with a user‐friendly pressure datalogger
Authors: Leite Pedro A. M. , Di Prima Simone , Schmidt Logan M. , Wilcox Bradford P. 
Published: July 2024

AbstractWe have constructed a new, simplified constant‐head infiltrometer automated with a self‐contained water level datalogger (HOBO U20L‐01) repurposed to measure changes in gas pressure inside an inverted bottle reservoir. Our field tests of six of these infiltrometers confirmed that recorded changes in gas pressure were strongly correlated with changes in water level in the infiltrometer reservoir (R2 = 0.9998). Further, by using the derived experimental calibration function, we were able to obtain accurate near‐steady‐state infiltration rates. This infiltrometer is cheaper and lighter than current commercially available infiltrometers. It can be easily assembled with materials readily available in most hardware stores, and its user‐friendly datalogger does not require any programming knowledge. This infiltrometer is compatible with various ponding infiltration methods, and its generic design allows for modifications with locally available materials to meet diverse research needs.
The Independence of Prosecutors: Cornerstone of the Rule of Law and Precondition for the Overall Independence of a Judicial System
Authors: Guglielmi Mariarosaria 
Published: July 2024

AbstractIt is clear that in the current crisis of the Rule of Law, that in recent years harvested a systematic weakening of the independence of the judiciary in Europe (and its sheer disappearance in Turkey, Hungary and Poland), what is endangered are the rights and freedoms of citizens.
Equational Anti-unification over Absorption Theories
Authors: Ayala-Rincón Mauricio , Cerna David M. , Barragán Andrés Felipe González , Kutsia Temur 
Published: July 2024

AbstractInterest in anti-unification, the dual problem of unification, is rising due to various new applications. For example, anti-unification-based techniques have been used recently in software analysis and related areas such as clone detection and automatic program repair. While syntactic forms of anti-unification have found many interesting uses, some aspects of modern applications are more appropriately modeled by reasoning modulo an equational theory. Thus, extending existing anti-unification methods to deal with important equational theories is the natural step forward. This paper considers anti-unification modulo pure absorption theories, i.e., where some function symbols are associated with a special constant satisfying the axiom $$f(x,\varepsilon _{f}) \,\approx \, f(\varepsilon _{f},x) \,\approx \, \varepsilon _{f}$$

f

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. We provide a sound and complete rule-based algorithm for such theories. Furthermore, we show that anti-unification modulo absorption is infinitary. Despite this, our algorithm terminates and produces a finitary algorithmic representation of the minimal complete set of solutions.
Solving Quantitative Equations
Authors: Ehling Georg , Kutsia Temur 
Published: July 2024

AbstractQuantitative equational reasoning provides a framework that extends equality to an abstract notion of proximity by endowing equations with an element of a quantale. In this paper, we discuss the unification problem for a special class of shallow subterm-collapse-free quantitative equational theories. We outline rule-based algorithms for solving such equational unification problems over generic as well as idempotent Lawvereian quantales and study their properties.