bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of 2022 flood on socio-economic and health status of people residing in flood-stricken areas of Pakistan: a cross-sectional survey
Authors: Khan Qaisar Ali , Jan Ayiz , Iram Sumaira , Haider Iqbal , Badshah Aliena , Khan Arooba , Hidayat Aabdar , Farrukh Ameer Mustafa , Ain Hoor Ul , Verma Ravina 
Published: August 2024

Background:
The events of extreme weather and climate-related disasters such as drought, flood, and heat waves are increasing worldwide. This paper highlights the impact of the 2022 flood in Pakistan on the socio-economic and health status of people residing in flood-stricken areas of Pakistan.

Methodology:
A post-flood survey was conducted from three districts of Pakistan with a myriad of questions inquiring about the biopsychosocial aspects of the affected community. Data were collected through a validated questionnaire and was analyzed through SPSS software version 25.

Results:
Forty percent of people became homeless; the number of individuals with a low income decreased by 9%; and the number of individuals with a moderate income decreased by 22%. Additionally, 48.7% of subjects lost their income due to flooding, 83.4% of subjects reported having some type of illness or disability since the flooding (previously 16.4%), and 92.8% believed that the floods had affected the health and sanitation of their area. Importantly, 22.6% of subjects expressed difficulty in accessing food after flooding compared to before and 59.9% of respondents noted they were unaware of proper pre-flood evacuation protocols in their area.

Conclusion:
The authors’ study indicates that the floods had a significant impact on the socio-economic and health status of residents, particularly those with lower incomes depriving a large proportion of nutrition, health facilities, and property. Without access to necessities and healthcare, individuals are more vulnerable to illnesses, such as chronic respiratory disease, diabetes, and heart disease. The authors stress the importance of providing infrastructural, nutritional, and medical services support to ensure that a community such as Pakistan can recover and thrive post-environmental disaster.
The efficacy of virtual reality-based rehabilitation in improving motor function in patients with stroke: a systematic review and meta-analysis
Authors: Prajjwal Priyadarshi , Chandrasekar Kiran Kishor , Battula Pavani , Gaviria Elizabeth , Awe Mishael Oluwadamilola , Inban Pugazhendi , Almutairi Adel S. , Das Arpan , Tekuru Yogesh , Marsool Mohammed Dheyaa Marsool , Reddy Murali Mohan , Mitra Spandana , Bamba Hyma , Singh Gurmehar , Jain Hritvik , Gadam Srikanth , Hussin Omniat Amir 
Published: August 2024

Background:
Stroke is a major cause of adult disability, prompting the exploration of innovative rehabilitation methods. Virtual rehabilitation (VR), leveraging technological advances, has gained popularity as a treatment for stroke recovery.

Methodology:
The authors conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) published in English within the last decade, adhering to the PRISMA guidelines. The authors searched databases such as Medline/PubMed, and the Cochrane Library using specific search keywords and Medical Subject Headings (MeSH). The methodological quality was assessed using the PEDro scale, focusing on RCTs involving adult stroke patients undergoing VR rehabilitation, with outcomes related to motor function and quality of life.

Results:
The authors included 15 studies in our meta-analysis. VR rehabilitation offers several advantages over traditional therapy, such as enhanced feedback and increased patient motivation. Engaging VR environments helps improve focus during treatment, potentially boosting recovery from post-stroke impairments. VR therapies significantly benefit motor function, which can improve activities of daily living and overall quality of life.

Conclusion:
VR has demonstrated efficacy in improving motor function and quality of life for stroke survivors. Future research should explore patient variability and refine intervention methods. Incorporating VR into rehabilitation programs could optimize stroke recovery outcomes.
Impact of Regional Surgeon Competition on Use, Cost, and Outcomes of Breast Reconstruction in the United States
Authors: Fahmy Joseph N. , Nasser Jacob S. , Wu Hao , Wang Lu , Chung Kevin C. 
Published: August 2024

Background:
Breast reconstruction following mastectomy is underused in the United States. Evidence suggests that more competitive hospital markets offer increased access to procedural care across specialties. This study aimed to determine the impact of regional plastic surgeon competition on use, outcomes, and cost of breast reconstruction following mastectomy for breast cancer.

Methods:
The authors conducted a retrospective cross-sectional analysis using MarketScan claims data from 2009 to 2020. The Herfindahl–Hirschman Index, a measure of market concentration, was calculated using the sum of squares of the proportion of breast reconstruction cases performed by each surgeon in a metropolitan statistical area. Multivariable logistic regression was used to identify differences in rates, outcomes, and costs of reconstruction by the Herfindahl–Hirschman Index.

Results:
Odds of receiving breast reconstruction within 2 years of mastectomy were higher for those in moderately competitive (OR, 1.51 [95% CI, 1.37 to 1.66]; P < 0.001) or competitive (OR, 1.71 [95% CI, 1.58 to 1.86]; P < 0.001) regions compared with noncompetitive regions. Patient out-of-pocket costs decreased when comparing moderately competitive regions with noncompetitive regions (−$67.38 [95% CI, −$88.65 to −$46.11]; P = 0.007), and decreased further when comparing competitive with noncompetitive regions (−$113.06 [95% CI, −$137.00 to −$89.12]; P = 0.02). No linear association between total, surgeon, or facility cost and market competition strata was identified.

Conclusions:
Greater competition among surgeons is associated with improved access to reconstructive surgery, but no difference in cost. Application of this evidence may include system-level strategies to bolster care coordination, while targeting drivers of cost, such as hospitals and hospital systems, through policy.
FDG PET/CT in an Interesting Case of Paraneoplastic Relapsing Polychondritis Associated With Adenocarcinoma of the Lung
Authors: Purohit Priyavrat , Preet Komal , Mittal Bhagwant Rai , Kumar Rajender , Singh Harmandeep , Sharma Aman , Singh Navneet 
Published: August 2024

AbstractRelapsing polychondritis (RP) is an uncommon autoimmune disease that causes inflammation of the cartilage and proteoglycan-rich structures, including the ear, nose, and airway. Paraneoplastic RP is a subset of RP that occurs in some individuals following the detection and treatment of certain types of cancers. FDG PET/CT helps with early diagnosis of RP, identifying inflammatory areas even in the absence of symptoms, and guiding the selection of appropriate biopsy sites. Here, we present a case of adenocarcinoma of the lung presenting with paraneoplastic symptoms of RP as initial presentation, and symptoms were resolved after 3 cycles of chemotherapy.
CXCR4-Targeted 68Ga-Pentixafor PET/CT Imaging in Inflammatory Bowel Disease
Authors: Chen Yang , Yuan Hui , Tan Xiaoyue , Shang Yuxiang , Sun Xiaolin , Wang Peng , Jiang Lei 
Published: August 2024

Purpose
To investigate the role of CXCR4-targeted 68Ga-pentixafor PET/CT imaging in inflammatory bowel disease (IBD).

Methods
Five IBD patients and 12 control subjects performing 68Ga-pentixafor PET/CT examinations were included. 68Ga-pentixafor PET/CT imaging and endoscopic findings were recorded and compared. The semiquantitative parameters of 68Ga-pentixafor uptake by the lesion segments in IBD patients and the normal intestines in the control were investigated.

Results
Among these 5 IBD patients, endoscopy successfully examined a total of 26 intestinal segments, with 13 segments showing endoscopic lesions. 68Ga-pentixafor PET/CT was positive in all endoscopy-proven lesions (13/13). Additionally, 68Ga-pentixafor PET/CT revealed the lesions in small intestines and colons that cannot be reached by endoscopy due to severe stenosis, and mesenteric lymphadenitis accompanied IBD. The SUVmax of the lesion segments in IBD patients was significantly higher than that of the normal intestines in the control group (median, 3.15 [range, 1.61–6.26] vs 1.67 [1.18–2.29], P < 0.001). Moreover, the SUVmax ratios of the lesion segments/liver or blood pool were higher when compared with the control (2.20 [1.13–3.26] vs 0.85 [0.54–1.20]; 1.66 [0.94–2.95] vs 0.67 [0.52–1.04]; P ≤ 0.001).

Conclusion

68Ga-pentixafor PET/CT can be a potentially valuable tool to assess the active intestinal lesions of IBD with high sensitivity. Moreover, this noninvasive approach does not require fasting or bowel preparation, offering good tolerance and safety.
Improvement of Laboratory Hepatic Parameters After Treatment With 177Lu-DOTATATE
Authors: dos Santos Soares Filipe , de Carvalho Juliana Ribeiro , de Lima Beatriz Arruda Matheos , Felix Renata Christian Martins , Bulzico Daniel Alves , Pujatti Priscilla Brunelli 
Published: August 2024

Purpose
Well-differentiated neuroendocrine neoplasms (NETs) overexpress the somatostatin receptor, which is the target for the peptide receptor radionuclide therapy (PRRT). NETs have a slow growth rate and can metastasize to liver, bone, and lungs. In NETs patients, liver metastasis is an important prognostic marker because liver failure is one of the most common causes of death in this population. In this regard, we aimed to describe the changes in laboratorial parameters in patients submitted to PRRT with 177Lu-DOTATATE, focusing on hepatic parameters.

Patients and Methods
One hundred ten patients treated with 1 to 4 cycles of 7.4 GBq (200 mCi) of 177Lu-DOTATATE from January 2011 to December 2021 were analyzed in this retrospective observational single-center study. Patients were submitted to blood tests before and after each cycle of PRRT. Laboratory measurements were collected to assess liver function, cholestasis, kidney, and bone marrow function.

Results
In the general population (n = 110), ALP (P = 0.013) and GGT (P < 0.001) showed a statistically significant reduction. Patients with high liver disease volume showed a statistically significant reduction in ALT (P = 0.016), whereas patients with low liver disease volume showed a statistically significant reduction in GGT (P = 0.013). All parameters for bone marrow function showed a statistically significant decrease in all population subsets.

Conclusions
Patients treated with 177Lu-DOTATATE showed a significant improvement in liver function and cholestasis parameters, and a consistent decrease in bone marrow function, even in the presence of advanced liver disease.
Prognostic Value of Bone Scintigraphy in Cardiac Amyloidosis
Authors: Cho Sang-Geon , Han Sangwon 
Published: August 2024

Objectives
The prognostic value of bone scintigraphy in cardiac amyloidosis (CA) remains undetermined. We conducted a systematic review and meta-analysis on the association of cardiac uptake on bone scintigraphy with mortality in known or suspected CA.

Patients and Methods
PubMed, Embase, and Cochrane library databases were searched up to November 2023 for studies that evaluated cardiac uptake on bone scintigraphy as a prognostic factor in the workup of CA. Hazards ratios (HRs) of high cardiac uptake for outcomes of all-cause or cardiac death were pooled and analyzed with stratifications according to the study populations, analytical methodologies, and radiotracers.

Results
Fourteen studies (3325 patients) were finally included. In studies regarding known or suspected CA, visual grades were not prognostically significant, regardless of the threshold used, with pooled HRs of 2.25 (95% confidence interval [CI], 0.93–5.48), 1.55 (95% CI, 0.89–2.68), and 1.53 (95% CI, 0.95–2.47) for visual grades ≥1, ≥2, and ≥3, respectively. By contrast, high cardiac uptake on semiquantitative measurements (heart-to-contralateral lung ratio, n = 6; heart-to-whole-body ratio, n = 1) was associated with increased mortality (pooled HR = 2.27 [95% CI, 1.87–2.76] for all semiquantitative measurements; 2.26 [1.86–2.74] for heart-to-contralateral lung ratio only). No difference in prognostic significance was found across 3 different 99mTc-radiotracers (P = 0.619). However, high cardiac uptake was not predictive of mortality in aortic stenosis-related CA (pooled HR = 1.13 [95% CI, 0.96–1.32]).

Conclusions
High semiquantitative cardiac uptake on bone scintigraphy is associated with an increased risk of mortality in patients with known or suspected CA.
Use of Electroconvulsive Therapy in Children and Adolescents With Catatonia—A Case Series
Authors: Pal Reeti , Cheng Tiffany , Eddington Sarah , Subramanian Subha , Wenzinger Michael , Cristancho Pilar 
Published: August 2024

Background
Electroconvulsive therapy (ECT) is highly efficacious in catatonia yet remains underutilized in pediatric patients. Practice guidelines recommend bilateral placement in cases with urgent need for response such as catatonia. Because of significantly lower cognitive burden and efficacy (compared to bilateral), right unilateral placement (RUL) is preferred for major depression. Increasing literature shows RUL is effective for catatonia in adults, but its use in catatonic youth is largely unknown.

Objectives
The aims of the study are to describe naturalistic outcomes of ECT in pediatric patients with catatonia and to discuss ECT parameter considerations.

Methods
This is a retrospective chart review of patients under 18-years of age at Saint Louis Children's Hospital with diagnosis of catatonia who received ECT from 2019 to November 2023. All cases received ECT per clinical protocol. Catatonic symptoms were monitored using the Busch Francis Catatonia Scale. Institutional review board approved the study.

Results
Twelve inpatients with debilitating catatonia and a failed benzodiazepine trial underwent ECT. Ten of these 12 patients initiated RUL placement, one received bifrontal, and another bilateral. All patients achieved resolution of catatonia: 6 patients with RUL alone and 4 who started with RUL later switched to bilateral due to nonresponse. The patient receiving bifrontal switched to bilateral due to nonresponse. Patients with malignant catatonia preferentially responded to bilateral placement. Patients experienced expected side effects from ECT.

Conclusions
RUL ECT was effective for catatonia in pediatric patients and can be considered as initial placement. A switch to bilateral can be considered in nonresponse, similar to current approach for major depression. For malignant catatonia, bilateral placement remains preferential.
Psychological Impact of the 2023 Kahramanmaraş Earthquakes on Non-Victims
Authors: Çınaroğlu Metin , Yılmazer Eda , Alpugan Zeynep , Sayar Gökben Hızlı 
Published: August 2024

AbstractThe 2023 Kahramanmaraş earthquakes, with magnitudes of 7.7 and 7.6, caused extensive destruction and psychological distress across southeastern Turkey. This study explores the psychological impact on non-victims, particularly Istanbul residents, focusing on mental health outcomes and coping mechanisms. A cross-sectional survey was conducted from March to May 2024 with 721 participants from various Turkish cities, including a significant portion from Istanbul. Validated psychological scales such as the Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), Warwick-Edinburgh Mental Well-being Scale (WEMWBS), and PTSD Checklist for DSM-5 (PCL-5) measured depression, anxiety, well-being, and PTSD symptoms. Sociodemographic factors like age, gender, occupation, income, education level, and previous earthquake experience were also analyzed.Results showed significant psychological distress among non-victims: 51.9% reported high levels of distress, with 24% meeting PTSD criteria, 30% exhibiting moderate to severe depression, and 28% experiencing significant anxiety. Higher income and education levels correlated with better mental health outcomes. Higher education levels were linked to lower PTSD risk (β = -0.20, p < 0.01) and fewer depression symptoms (β = -0.15, p < 0.05). Higher income was associated with lower depression scores (β = -0.20, p < 0.01) and fewer PTSD symptoms (β = -0.15, p < 0.05). Age positively correlated with well-being (r = 0.68, p < 0.001) and negatively with PTSD symptoms (r = -0.15, p < 0.05).Comparisons with victim studies of major earthquakes, such as the 1995 Great Hanshin-Awaji earthquake, the 1999 Marmara earthquake, the 2008 Wenchuan earthquake, and the 2000 Iceland earthquakes, revealed similar profound psychological impacts. This highlights the need for comprehensive mental health interventions for both direct and indirect exposures. This study underscores the necessity for inclusive mental health strategies to enhance resilience and well-being, ensuring robust recovery after catastrophic events.
Changes in self-reported alcohol consumption at high and low consumption in the wake of the COVID-19 pandemic: A test of the polarization hypothesis
Authors: Tran Alexander , Jiang Huan , Lange Shannon , Štelemėkas Mindaugas , Stumbrys Daumantas , Tamutienė Ilona , Rehm Jürgen 
Published: August 2024

AbstractBackgroundThe Coronavirus Disease 2019 (COVID-19) pandemic and associated public health measures had an impact on alcohol use. Based on the literature of past crises (health, economic, etc.), it was hypothesized that the COVID-19 pandemic led to a polarization of drinking–that is, heavy drinkers increased their drinking, while light to moderate drinkers decreased their drinking and/or temporarily abstained. The aim of the current study was to test the respective hypothesis.MethodsData from the Reducing Alcohol Related Harm Standard European Alcohol Survey for Lithuania were obtained for 2015 and 2020. Average daily consumption (in grams per day) was decomposed into deciles for each year, and compared pre-COVID to onset-of-COVID pandemic across the highest, second highest, and lowest deciles. A comparison of population-levels of mental health was conducted between pre-COVID and the onset-of-COVID.ResultsThe findings indicated that overall, there was higher consumption in 2015, M2015= 11.49 (SD = 8.23) vs. M2020= 10.71 (SD = 12.12), p < .00001. However the opposite was found in the highest decile M2015= 29.26 (SD = 5.44) vs. M2020= 39.23 (SD = 20.58),p= .0003. This reversal pattern was not observed in the second highest nor the lowest decile. There was a lower proportion of respondents indicating “bad” mental health pre- vs.post-COVID (3.4% vs. 6.5%).ConclusionAlthough COVID was associated with nationwide declines in alcohol consumption, this was not the case for all segments of the population. In Lithuania, it appears that there was an increase in consumption among the heaviest drinkers, supporting the polarization hypothesis.
Gene transfer of human cardiomyopathy β-MyHC mutant R403Q directly alters intact cardiac myocyte calcium homeostasis and causes hyper-contractility
Authors: Herron Todd J. , Devaney Eric , Guerrero-Serna Guadalupe , Mundada Lakshmi , Metzger Joseph M. 
Published: August 2024

AbstractThe R403Q mutation of human cardiac β-myosin heavy chain was the first missense mutation of a sarcomeric protein identified as being causal for hypertrophic cardiomyopathy (HCM), in humans. The direct effect of the R403Q mutant myosin on intracellular calcium homeostasis and contractility is not fully known. Here we have usedin vitrogene transfer of the R403Q mutant human β-myosin to study its direct effects on single intact adult cardiac myocyte contractility and calcium homeostasis. In the first experiments, adult cardiac myocytes transduced with the R403Q mutant myosin recombinant viral vectors were compared to myocytes transduced with wild-type human β-myosin (wtMYH7). Efficiency of gene transfer was high in both groups (>98%) and the degree of stoichiometric myofilament incorporation of either the mutant or normal myosin was comparable at ∼40% in quiescent myocytes in primary culture. Sarcomere structure and cellular morphology were unaffected by R403Q myosin expression and myofilament incorporation. Functionally, in electrically paced cardiac myocytes, the R403Q mutant myosin caused a significant increase in intracellular calcium concentration and myocyte hyper-contractility. At the sub-cellular myofilament level, the mutant myosin increased the calcium sensitivity of steady state isometric tension development and increased isometric cross-bridge cycling kinetics. R403Q myocytes became arrhythmic after β-adrenergic stimulation with spontaneous calcium transients and contractions in between electrical stimuli. These results indicate that human R403Q mutant myosin directly alters myofilament function and intracellular calcium cycling. Elevated calcium levels may provide a trigger for the ensuing hypertrophy and susceptibility to arrhythmia that are characteristic of HCM.
Mapping the landscape: a bibliometric review of mergers and acquisitions through the lens of sustainability
Authors: Begum N. Ayisha , Shaik Saleem 
Published: August 2024

Purpose
The purpose of this study of M&A in relation to sustainability aims to create synergies that drive both financial performance and positive environmental and social outcomes, aligning business objectives with broader societal goals. The study can help in understanding the structure, collaborations and recent keywords and topics that are related to M&A in relation to sustainability.

Design/methodology/approach
This study applies comprehensive bibliometric analysis on performance analysis and science mapping of the scholarly literature related to M&A in relation to sustainability published between 2004 and 2024 in 196 publications on Web of science and Scopus by leveraging biblioshiny within R Studio and the VOS viewer software for enhanced visualization and interpretation of the bibliometric data.

Findings
This study helps to find out the co-occurrence analysis, bibliographical coupling and keyword analysis. Moreover, it scrutinizes patterns of collaboration among researchers, institutions and nations, shedding light on the global reach and influence of scholarly contributions in the field of M&A in relation to sustainability.

Practical implications
This study identified trends can help scholars, policymakers and business experts to study M&A through the lens of sustainability.

Social implications
This bibliometric study of M&A in relation to sustainability can drive positive change by promoting responsible business practices, fostering innovation and creating value for both shareholders and society as a whole.

Originality/value
The paper concludes by finding emerging topics of the research and future directions, it gives a good input to extend the line on the graph. This study provides overview of 20 years of research on M&A in relation to sustainability and discusses its findings to identify the research gap.