bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embolization with or without portal vein stenting for bleeding ectopic jejunal varices in hepatopetal portal collaterals due to extrahepatic portal vein occlusion or stenosis after hepatobiliary and pancreatic surgery
Authors: Ogawa Satoyuki , Yamamoto Akira , Jogo Atsushi , Kageyama Ken , Sohgawa Etsuji , Ohira Go , Kimura Kenjiro , Tanaka Shogo , Amano Ryosuke , Takemura Shigekazu , Ishizawa Takeaki , Miki Yukio 
Published: June 2024

Abstract
Purpose
To evaluate the efficacy and safety of embolization with or without portal vein stenting for bleeding ectopic jejunal varices in the hepatopetal portal collateral due to extrahepatic portal vein occlusion or stenosis after hepatobiliary and pancreatic surgery.

Materials and methods
This study included consecutive patients who underwent embolization for bleeding ectopic jejunal varices in the hepatopetal collateral due to extrahepatic portal vein occlusion or stenosis after hepatobiliary and pancreatic surgery between September 2012 and December 2020. The safety, technical and clinical success rates (no re-bleeding within 1 month) and re-bleeding-free survival after the first therapy and overall survival were assessed.

Results
Fourteen sessions in 11 patients were included. Four patients (7 sessions) underwent variceal embolization only, and the remaining seven patients (7 sessions) underwent portal vein stenting and variceal embolization. Technical success was achieved in all 14 sessions (100%). Clinical success was achieved in 13 of 14 sessions (92.9%). No treatment-related serious complications including liver failure were observed. One-year and 2-year re-bleeding-free survival rate after the first endovascular therapy in all 11 patients was 90.9 and 60.6%, respectively. Two patients who experienced re-bleeding had repeat embolization treatment. There was no significant difference in re-bleeding-free survival after endovascular therapy between the combination with stenting and embolization group and the embolization-only group (p = 0.13).

Conclusion
Embolization with or without portal vein stenting of bleeding ectopic jejunal varices in the hepatopetal portal collateral due to extrahepatic portal vein occlusion or stenosis after hepatobiliary and pancreatic surgery can be considered a safe, effective, and repeatable therapy for long-term hemostasis of uncontrollable bleeding.
Parental Knowledge and Attitudes Towards Helicobacter Pylori Screening in Adolescents: A School-Based Questionnaire Study Among Guardians of Junior High School Students in Yokosuka City, Japan
Authors: Saito Hiroaki , Uchiyama Taiga , Matsuoka Mikio , Kakiuchi Toshihiko , Eguchi Yuichiro , Tsubokura Masaharu , Mizuno Yasuhiro 
Published: June 2024

Abstract
Purpose
Helicobacter pylori (HP) infection, a risk factor for gastric cancer, is prevalent in Japan. Consequently, some municipalities across Japan are implementing HP screening and treatment programs for adolescents. However, little is known about parents’ attitudes and awareness regarding HP screening for their children. This study aimed to elucidate parental perspectives on HP screening for their children and identify the factors influencing these attitudes.

Methods
This study focused on the parents of first-year junior high school students in Yokosuka City, Kanagawa Prefecture, where an HP screening and treatment program had been implemented for adolescents. The survey questionnaire was distributed among parents in all 23 public junior high schools in Yokosuka City.

Results
Among the 618 respondents, 86.4% supported HP screening for their children. Regression analysis identified sufficient knowledge about HP (adjusted odds ratio (aOR) = 5.80; 95% confidence interval (CI), 2.10–16.03) and being in their 40s (aOR = 2.25; 95% CI, 1.35–3.77) as significant factors influencing supportive attitudes. For parents favoring the screening, common reasons included perceiving it as a promising opportunity (53.2%) and considering the test necessary (44.0%). In contrast, those who opposed screening frequently cited it as unnecessary (66.7%) or believed that their children did not have HP.

Conclusions
A significant proportion of parents in Yokosuka City, Japan, demonstrated a good understanding of HP and expressed a high level of interest in HP screening for their children. Further investigation of parents’ attitudes is essential for the effective implementation of adolescent HP screening programs.
Is the Self-Categorization of Social Network Consumption Related to Subjective Well-Being? A Longitudinal Study of Spanish Adolescents
Authors: Malo Cerrato Sara , Benítez Baena Isabel , González-Carrasco Mònica 
Published: June 2024

AbstractThe impact of social network consumption on adolescents’ subjective well-being (SWB) has remained a subject of debate in cross-sectional studies, and the understanding of how changing social network consumption patterns affect SWB over time is even more limited. This study adopts an innovative approach, utilizing various measurement scales to assess adolescents’ SWB alongside the evolution of their SSNC patterns. A four-wave longitudinal study was conducted involving 341 participants aged 9 to 14 from Spain. The findings indicate that as adolescents age, their perception of SSNC increases, while SWB declines over time. Adolescents categorizing themselves as low consumers of social networks consistently exhibited higher SWB scores than those with medium and high consumption levels. Notably, the relationship between SSNC and SWB showed variations depending on the measurement scale used. An analysis of the evolution of social network consumption profiles (SNCPs) revealed four distinct profiles, although these were not linked to changes in SWB over time. Finally, participants with an extreme consumption profile consistently exhibited significantly lower SWB scores. These findings underscore the importance of continuously monitoring social media use and its effects on SWB, especially within subgroups displaying more extreme consumption patterns, an insight that has implications for preventive interventions.
Logarithmic Sobolev-Type Inequalities on Lie Groups
Authors: Chatzakou Marianna , Kassymov Aidyn , Ruzhansky Michael 
Published: June 2024

AbstractIn this paper we show a number of logarithmic inequalities on several classes of Lie groups: log-Sobolev inequalities on general Lie groups, log-Sobolev (weighted and unweighted), log-Gagliardo–Nirenberg and log-Caffarelli–Kohn–Nirenberg inequalities on graded Lie groups. Furthermore, on stratified groups, we show that one of the obtained inequalities is equivalent to a Gross-type log-Sobolev inequality with the horizontal gradient. As a result, we obtain the Gross log-Sobolev inequality on general stratified groups but, very interestingly, with the Gaussian measure on the first stratum of the group. Moreover, our methods also yield weighted versions of the Gross log-Sobolev inequality. In particular, we also obtain new weighted Gross-type log-Sobolev inequalities on $${\mathbb {R}}^n$$

R

n

for arbitrary choices of homogeneous quasi-norms. As another consequence we derive the Nash inequalities on graded groups and an example application to the decay rate for the heat equations for sub-Laplacians on stratified groups. We also obtain weighted versions of log-Sobolev and Nash inequalities for general Lie groups.
LPA1 antagonist-derived LNPs deliver A20 mRNA and promote anti-fibrotic activities
Authors: Yan Jingyue , Kang Diana D. , Wang Chang , Hou Xucheng , Du Shi , Wang Siyu , Xue Yonger , Liu Zhengwei , Li Haoyuan , Zhong Yichen , Deng Binbin , McComb David W. , Dong Yizhou 
Published: June 2024

AbstractActivated fibroblasts are major mediators of pulmonary fibrosis. Fibroblasts are generally found in the connective tissue but upon activation can generate excess extracellular matrix (ECM) in the lung interstitial section. Therefore, fibroblasts are one of the most targeted cells for treating idiopathic pulmonary fibrosis (IPF). Here, we develop an anti-fibrotic platform that can modulate both the lysophosphatidic acid receptor 1 (LPA1) and the inflammatory pathway through tumor necrosis factor α-induced protein 3 (TNFAIP3, also known as A20) in fibroblasts. First, we synthesized a series of LPA1 antagonists, AM095 and AM966, derived amino lipids (LA lipids) which were formulated into LA-lipid nanoparticles (LA-LNPs) encapsulating mRNA. Specifically, LA5-LNPs, with AM966 head group and biodegradable acetal lipid tails, showed efficient A20 mRNA delivery to lung fibroblasts in vitro (80.2% ± 1.5%) and ex vivo (17.2% ± 0.4%). When treated to primary mouse lung fibroblasts (MLF), this formulation inhibited fibroblast migration and collagen production, thereby slowing the progression of IPF. Overall, LA5-LNPs encapsulated with A20 mRNA is a novel platform offering a potential approach to regulate fibroblast activation for the treatment of IPF.
Non-Thermal Processing Technologies for Allergen Control in Alternative Protein Sources for Food Industry Applications
Authors: Dong Gaoya , Hinds Laura M. , Soro Arturo B. , Hu Zhipeng , Sun Da-Wen , Tiwari Brijesh K. 
Published: June 2024

AbstractSustainable food practices within the food industry are pertinent to allow efficient food supply while not negatively impacting the environment. Alternative proteins have gained the attention of the food industry and consumers. To provide safe novel food products, these protein sources need to be assessed for potential allergen risk to ensure food safety and allow effective labelling to protect the consumer. In this review, the various detection assays applied to target potential allergens in novel and alternative foods are described together with their applications, mechanisms and limitations. Additionally, the use of non-thermal technologies to mitigate the reactivity of food allergens in these new products is explored. Non-thermal techniques including cold plasma, pulsed electric field, ultrasound and gamma irradiation are discussed. This review examines the potential mechanisms by which non-thermal technologies may reduce food allergenicity, primarily through alterations in protein epitopes that could affect antibody recognition. However, it is important to note that the understanding of the precise mechanisms and outcomes in allergen mitigation through these methods remains an area requiring further research.
Analyzing operational risks of digital supply chain transformation using hybrid ISM-MICMAC method
Authors: Hasani Aliakbar , Haseli Gholamreza , Deveci Muhammet 
Published: June 2024

AbstractIdentifying and prioritizing risks is crucial for the successful digital transformation of a supply chain's key processes without disruption. An organized and comprehensive risk assessment framework will significantly ensure a sustainable transformation to a digital supply chain. In this study, digital transformation risks are identified and prioritized using a hybrid fuzzy multi-criteria decision-making (MCDM) method under uncertainty. Additionally, appropriate risk mitigation strategies for the top-ranked risks are presented, and potential relationships among them are addressed. Initially, potential risks in digital transformation were identified based on expert opinions. A fuzzy hierarchical and analytic network process was then applied to determine the importance of evaluation criteria and the final ranking of potential risks, respectively. Efficient risk mitigation strategies were proposed, and interrelationships among them were assessed using interpretive structural modeling and a matrices impacts croisés multiplication appliquée à un classement (MICMAC) analysis. The results indicate that information technology risk, supply chain management risk, and financial risks are the top three risks in the identified ranking. Furthermore, implementing an integrated data strategy and proposing comprehensive business agreements with supply chain players are considered the most impactful strategies for risks with top ranks.
Verständlichkeit mündlicher Erklärungen von Sportlehrkräften
Authors: Heemsoth Tim , Krieger Claus , Frerichs Rieke , Schmitz Anke , Wallot Sebastian , Härtig Hendrik , Leiss Dominik 
Published: June 2024

ZusammenfassungGute mündliche Erklärungen von Sportlehrkräften werden als mitentscheidend für das Verständnis von Schüler*innen im Sportunterricht angenommen. Dabei ist jedoch unklar, welche Merkmale in einer mündlichen Erklärung so zur Verständlichkeit beitragen, dass sie das Verstehen von Schüler*innen besonders fördern. Die vorliegende experimentelle Studie mit N = 356 Schüler*innen der Klassenstufen 7–9 variiert dafür im Rahmen eines 2 × 2-Designs die zwei Kohärenzbildungshilfen sprachliche Segmentierung (hoch vs. gering) und Qualität der zusammenfassenden Situationsbeispiele (regelkonform vs. regelwidrig) in einer videografierten mündlichen Erklärung des Spiels Kin-Ball. Die Befunde deuten darauf hin, dass der Grad der Segmentierung weder eine Bedeutung für das Erinnern und Wiedergeben zentraler Spielregeln (Regelwissen) noch für das Analysieren und Evaluieren von Spielsituationen (Regelanwenden) hat. Das Regelwissen wird jedoch unterstützt, wenn die Erklärung mit regelwidrigen statt mit regelkonformen Spielsituationen zusammengefasst wird. Das Regelanwenden hingegen profitiert von einer Kombination aus hoher Segmentierung und regelkonformen Situationsbeispielen. Sämtliche Effekte der Kohärenzbildungshilfen sind von der selbst eingeschätzten Sprachfähigkeit der Schüler*innen unabhängig. Insgesamt kann die Studie zu einem besseren Verstehen bedeutsamer sprachlicher Kohärenzbildungshilfen in mündlichen Erklärungen im Fach Sport beitragen.
CSRP1 gene: a potential novel prognostic marker in acute myeloid leukemia with implications for immune response
Authors: Zhao Chunxia , Wang Yulu , Wang Huan , Sharma Amit , Wu Yun , Schmidt-Wolf Ingo G. H. , Wang Zifeng 
Published: June 2024

Abstract
Background
Acute myeloid leukemia, constituting a majority of leukemias, grapples with a 24% 5-year survival rate. Recent strides in research have unveiled fresh targets for drug therapies. LIM-only, a pivotal transcription factor within LIM proteins, oversees cell development and is implicated in tumor formation. Among these critical LIM proteins, CSRP1, a Cysteine-rich protein, emerges as a significant player in various diseases. Despite its recognition as a potential prognostic factor and therapeutic target in various cancers, the specific link between CSRP1 and acute myeloid leukemia remains unexplored. Our previous work, identifying CSRP1 in a prognostic model for AML patients, instigates a dedicated exploration into the nuanced role of CSRP1 in acute myeloid leukemia.

Methods
R tool was conducted to analyze the public data. qPCR was applied to evaluate the expression of CSRP1 mRNA for clinical samples and cell line. Unpaired t test, Wilcoxon Rank Sum test, KM curves, spearman correlation test and Pearson correlation test were included in this study.

Results
CSRP1 displays notable expression variations between normal and tumor samples in acute myeloid leukemia (AML). It stands out as an independent prognostic factor for AML patients, showing correlations with clinical factors like age and cytogenetics risk. Additionally, CSRP1 correlates with immune-related pathways, immune cells, and immune checkpoints in AML. Furthermore, the alteration of CSRP1 mRNA levels is observed upon treatment with a DNMT1 inhibitor for THP1 cells.

Conclusion
The CSRP1 has potential as a novel prognostic factor and appears to influence the immune response in acute myeloid leukemia. Additionally, there is an observed association between CSRP1 and DNA methylation in acute myeloid leukemia.
Investigations of Differential Hypoxemia During Venoarterial Membrane Oxygenation with and Without Impella Support
Authors: Neidlin Michael , Amiri Ali , Hugenroth Kristin , Steinseifer Ulrich 
Published: June 2024

Abstract
Purpose
Venoarterial extracorporeal membrane oxygenation (VA ECMO) is used in patients with refractory cardiac or cardio-pulmonary failure. Native ventricular output interacts with VA ECMO flow and may hinder sufficient oxygenation to the heart and the brain. Further on, VA ECMO leads to afterload increase requiring ventricular unloading. The aim of the study was to investigate aortic blood flow and oxygenation for various ECMO settings and cannula positions with a numerical model.

Methods
Four different aortic cannula tip positions (ascending aorta, descending aorta, abdominal aorta, and iliac artery) were included in a model of a human aorta. Three degrees of cardiac dysfunction and VA ECMO support (50%, 75% and 90%) with a total blood flow of 6 l/min were investigated. Additionally, the Impella CP device was implemented under 50% support condition. Blood oxygen saturation at the aortic branches and the pressure acting on the aortic valve were calculated.

Results
A more proximal tip orientation is necessary to increase oxygen supply to the supra-aortic and coronary arteries for 50% and 75% support. During the 90% support scenario, proper oxygenation can be achieved independently of tip position. The use of Impella reduces afterload by 8–17 mmHg and vessel oxygenation is similar to 50% VA ECMO support. Pressure load on the aortic valve increases with more proximal tip position and is decreased during Impella use.

Conclusions
We present a simulation model for the investigation of hemodynamics and blood oxygenation with various mechanical circulatory support systems. Our results underline the intricate and patient-specific relationship between extracorporeal support, cannula tip orientation and oxygenation capacity.
A Novel Cooling System by Surface Corrugation and Nanofluid Utilization for the Performance Improvement of Photovoltaic Module Coupled with Thermoelectric Generator and Efficient Computations by Using Artificial Neural Network-Based Hybrid Scheme
Authors: Selimefendigil Fatih , Okulu Damla , Oztop Hakan F. 
Published: June 2024

AbstractFor a photovoltaic module coupled with thermoelectric generator, a unique wavy cooling channel is proposed, and its performance is numerically assessed by using three-dimensional computations. The cooling channel uses nanofluid of alumina–water with various shaped nanoparticles (spherical, cylindrical and brick). Numerical simulations are performed for a range of parameters for the corrugation amplitude ($$0 \le \text {Amp} \le 0.1$$

0
≤
Amp
≤
0.1

), wave frequency ($$2 \le \text {Nf} \le 16$$

2
≤
Nf
≤
16

), nanoparticle loading quantity ($$0 \le \text {SVF} \le 0.03$$

0
≤
SVF
≤
0.03

), and nanoparticle shape (spherical, brick, and cylindrical). We analyze the photovoltaic module’s average temperature and temperature uniformity for a variety of parameter variations. When nanofluid and greater channel corrugation amplitudes are utilized, the average panel surface temperature is decreased more. A wavy shape of the cooling channel at the maximum corrugation amplitude yields a cell temperature reduction of 1.88 $$^\text {o}$$

o

C, while frequency has little impact on average cell temperature and its uniformity. The best-performing particles are those with cylindrical shapes, and the drop-in average photovoltaic temperature with solid volume fraction is essentially linear. As utilizing cylindrical-shaped particles, the average temperature of corrugated cooling channels decreases by around 1.9 $$^\text {o}$$

o

C as compared to flat cooling channels with base fluid at the greatest solid volume fraction. As compared to un-cooled photovoltaic, cell temperature drops by around 43.2 $$^\text {o}$$

o

C when employing thermoelectric generator. However, temperature drop value of 59.8 $$^\text {o}$$

o

C can be obtained by using thermoelectric generator and nano-enhanced wavy cooling channel utilizing cylindrical-shaped nanoparticles. An hybrid computational strategy for the fully coupled system of photovoltaic with cooling system is provided, which reduces the computational time by a factor of 75.
System Identification Based on Experimental Technique Using Stability Boundary Locus Method for Linear Fractional Order Systems
Authors: Yüce Ali 
Published: June 2024

AbstractFractional calculus is an important mathematical tool that is widely used in control systems. It is established in the literature that fractional order models are more accurate and more effective in system modelling. In this study, an alternative and novel technique is proposed to identify the fractional order time-delayed model of an unknown system. The method is based on obtaining the approximate stability boundary locus (SBL) curve of the unknown system by applying three different experimental tests. Three points on the SBL curve are determined by the experimental tests and then the parameters of the fractional order time-delayed model are computed by solving the nonlinear systems of equation. The system model with double fractional order element plus a time delay is obtained using the proposed method. The proposed method is explained through simulations on a twin rotor system. The proposed method is also used in model order reduction calculation of the higher order transfer functions.
Trawling through time: reconstructing a late nineteenth century beam trawl for scientific inshore fishery investigations
Authors: Hunt Georgina L. , Engelhard Georg H. , Pinnegar John K. , Wigham Benjamin D. , Polunin Nicholas V. C. 
Published: June 2024

AbstractUnderstanding long-term change in fish populations often relies on comparing catches from historical and contemporary trawl surveys. However, such comparisons may not resolve biases associated with differences in fishing gears and their relative catchabilities. It is possible to reduce these uncertainties by replicating historical trawl gear and practices. With the availability of unique historical catch data, we investigated the trawl gear employed by the Northumberland Sea Fisheries Committee (NSFC) during scientific surveys conducted between 1892–1913 in inshore waters of the Northumberland coast (UK), and describe our attempt to reconstruct the gear using currently available materials. We reviewed the historical literature, photographs and acquired technical expertise to reconstruct a late nineteenth century beam trawl used by the NSFC. The replica gear consisted of a 6.7 m beam connected by two Brixham style wrought-iron trawl heads, which held open a triangular-shaped trawl net with rounded ground-rope. Following construction, we tested the performance and catchability of the replica gear by conducting comparative trawls using a modern otter trawl in August 2018 and March 2019. Both trawl gears exhibited similar catches for flatfish in August trials, yet a higher proportion of individuals were landed by the otter trawl in March. Zero or negligible catches were exhibited by the replica gear during this period. This work collates relevant information to describe the evolution, design and functioning of late nineteenth century beam trawls used around the British Isles, providing an important repository for investigators interested in trawl technology and survey designs.