bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Harnessing Applied Potential to Oxidation in Water.
Authors: Buckley Benjamin R. , Chan Yohan , Dreyfus Nicolas , Elliott Claire , Marken Frank , Page Philip C. Bulman 
Published: November 2012

AbstractA solvent‐free (biphasic) electrochemically driven oxidation system for the selective conversion of sulfides to the corresponding sulfoxides, and alkenes to epoxides, in a simple reactor system is described.
ChemInform Abstract: An Efficient Palladium‐NHC (NHC = N‐Heterocyclic Carbene) and Aryl Amination Pre‐Catalyst: [Pd(IPr*)(cinnamyl)Cl].
Authors: Chartoire Anthony , Frogneux Xavier , Nolan Steven P. 
Published: November 2012

AbstractPalladium complex PAL is an efficient catalyst at extremely low loading for the amination reaction of numerous aryl/pyridyl chlorides with primary or secondary amines at reflux temperature, or at some higher loading at room temperature.
ChemInform Abstract: Ligand Effects on the Stereochemistry of Stille Couplings, as Manifested in Reactions of (Z)‐Alkenyl Halides.
Authors: Lu Guo‐ping , Voigtritter Karl R. , Cai Chun , Lipshutz Bruce H. 
Published: November 2012

AbstractA new set of conditions is developed for the highly stereoselective and mild reaction of (Z)‐alkenyl halides along with improved yields.
ChemInform Abstract: Reactions of 1,4‐Enynes with the System CH2I2—Et3Al.
Authors: Ramazanov I. R. , Yaroslavova A. V. , Dzhemilev U. M. , Nefedov O. M. 
Published: November 2012

AbstractThe reaction of 1,4‐enynes (I) in the system diiodomethane / triethylaluminum is studied.
ChemInform Abstract: Cascade Carbopalladation Reaction Between Alkynes and gem‐Dibromoolefins: Facile Access to Monoanellated Pentalenes.
Authors: Rivera‐Fuentes Pablo , von Wantoch Rekowski Margarete , Schweizer W. Bernd , Gisselbrecht Jean‐Paul , Boudon Corinne , Diederich Francois 
Published: November 2012

AbstractThe chromophores are isolated as dark green to green‐brown solids.
ChemInform Abstract: Highly Enantioselective Addition of 1,3‐Diynes to Aldehydes Catalyzed by a Zinc—Amino Alcohol Complex.
Authors: Zheng Bing , Li Shuo‐Ning , Mao Jian‐You , Wang Bo , Bian Qing‐Hua , Liu Shang‐Zhong , Zhong Jiang‐Chun , Guo Hong‐Chao , Wang Min 
Published: November 2012

AbstractThe synthetic value of the present method is demonstrated by preparation of marine allynols (X).
ChemInform Abstract: One‐Pot Chemoenzymatic Synthesis of Aldoximes from Primary Alcohols in Water.
Authors: Zambelli Paolo , Pinto Andrea , Romano Diego , Crotti Elena , Conti Paola , Tamborini Lucia , Villa Raffaella , Molinari Francesco 
Published: November 2012

AbstractAn easy and efficient one‐pot methodology for the preparation of aldoximes combines the enzymatic oxidation of corresponding primary alcohols using different acetic acid bacteria and in situ condensation of the resulting aldehydes with hydroxylamine.
ChemInform Abstract: Aerobic Photooxidative Cleavage of Vicinal Diols to Carboxylic Acids Using 2‐Chloroanthraquinone.
Authors: Matsusaki Yoko , Yamaguchi Tomoaki , Tada Norihiro , Miura Tsuyoshi , Itoh Akichika 
Published: November 2012

AbstractA convenient procedure is developed for the title reaction.
ChemInform Abstract: An Efficient Organocatalytic Method for Highly Enantioselective Michael Addition of Malonates to Enones Catalyzed by Readily Accessible Primary Amine‐Thiourea.
Authors: Dudzinski Krzysztof , Pakulska Anna M. , Kwiatkowski Piotr 
Published: November 2012

AbstractDifferent ratios of TUCY/BzOH are found to optimal for the procedure, where diester (II) proves to be the best reactant.
ChemInform Abstract: The First Example for Cyanation of Arylboronic Acids with Nontoxic and Inexpensive K4[Fe(CN)6].
Authors: Tian Xinzhe , Sun Yanpei , Dong Chuanhua , Zhang Kaixuan , Liang Tengfei , Zhang Yu , Hou Chaodong 
Published: November 2012

AbstractA wide range of functionalized arylboronic acids and heterocyclic boronic acids is smoothly converted into the corresponding products.
ChemInform Abstract: Catalyst‐Free, One‐Pot, Expeditious Synthesis of Aminoalkylnaphthols at Room Temperature.
Authors: Mukhopadhyay Chhanda , Rana Sunil , Butcher Ray J. 
Published: November 2012

AbstractA very simple, catalyst‐free methodology for the multicomponent one‐pot synthesis of aminoalkylnaphthols and related coumarins (IX) is developed.
ChemInform Abstract: A Comparative Study in Oxidative Free Radical Reactions Between 9‐Benzylidene‐9H‐fluorene Derivatives and β‐Dicarbonyl Compounds in the Presence of Mn(OAc)3 and CAN.
Authors: Demirhan Hulya , Arslan Mustafa , Zengin Mustafa , Kucukislamoglu Mustafa 
Published: November 2012

AbstractAcetylacetone is also used as dicarbonyl starting material.
ChemInform Abstract: A Novel Class of Small‐Molecule Caspase‐3 Inhibitors Prepared by Multicomponent Reactions.
Authors: Zhu Qiuhua , Gao Lixin , Chen Zhipeng , Zheng Sichao , Shu Huafei , Li Jia , Jiang Huanfeng , Liu Shuwen 
Published: November 2012

AbstractA total of 39 tetra‐ and pentasubstituted polyfunctional dihydropyrrolones are synthesized via multicomponent reactions.
ChemInform Abstract: FeCl3‐Catalyzed Stereoselective Construction of Spirooxindole Tetrahydroquinolines via Tandem 1,5‐Hydride Transfer/Ring Closure.
Authors: Han Yan‐Yan , Han Wen‐Yong , Hou Xue , Zhang Xiao‐Mei , Yuan Wei‐Cheng 
Published: November 2012

AbstractThe reaction can also be carried out with some other Lewis acids, but a catalyst loading <10% gives only rise to trace amounts.
ChemInform Abstract: A Facile Synthesis of 4‐Acylamino‐tetrahydroindazoles via the Ritter Reaction.
Authors: Turks Maris , Strakova Inta , Gorovojs Kirils , Belyakov Sergey , Piven Yuri A. , Khlebnicova Tatyana S. , Lakhvich Fedor A. 
Published: November 2012

AbstractA new route to the title compounds proceeds via reaction of 4‐hydroxytetrahydroindazoles with various nitriles.
ChemInform Abstract: Dimedone‐Catalyzed Addition of Amines into Cyano Group: Facile Synthesis of Thiazol‐2‐yl Substituted E‐Acrylonitriles.
Authors: Zhu Weijun , Tu Xingchao , Feng Hui , Tu Mansu , Jiang Bo , Wu Feiyue , Tu Shujiang 
Published: November 2012

AbstractThe dimedone‐mediated addition of amines to a cyano group of (I) proceeds with high chemoselectivity and a broad scope of substrates can be employed.
ChemInform Abstract: Synthesis of 5‐Iodo‐1,4‐disubstituted‐1,2,3‐triazoles Mediated by in situ Generated Copper(I) Catalyst and Electrophilic Triiodide Ion.
Authors: Brotherton Wendy S. , Clark Ronald J. , Zhu Lei 
Published: November 2012

AbstractA one‐pot multicomponent synthesis of 5‐allylated analogues such as (VII) is possible.
ChemInform Abstract: Furazan‐Containing Bromoarenes in the Suzuki—Miyaura Reaction.
Authors: Vasil'ev A. A. , Struchkova M. I. , Sheremetev A. B. , Levinson F. S. , Varganov R. V. , Lyssenko K. A. 
Published: November 2012

AbstractThe Suzuki—Miyaura cross‐coupling reaction of bromoarenes substituted with or fused to the 1,2,5‐oxadiazole scaffold is studied.
ChemInform Abstract: cis‐Nitenpyram Analogues Containing 1,4‐Dihydropyridine: Synthesis, Insecticidal Activities, and Molecular Docking Studies.
Authors: Sun Chuanwen , Chen Yanxia , Liu Tianyan , Wu Ying , Fang Ting , Wang Jing , Xing Jiahua 
Published: November 2012

AbstractCompounds (IVa) and (IVc) exhibit the best insecticidal activity against Aphis medicagini.
ChemInform Abstract: Copper‐Catalyzed Activation of Dioxygen: Oxidative Cyclization of 2‐Arylindoles.
Authors: Sang Peng , Xie Yongju , Zou Jianwei , Zhang Yuhong 
Published: November 2012

AbstractA series of diindolo‐fused quinolines (18 examples) is prepared from two molecules of 2‐arylindoles and molecular oxygen.
ChemInform Abstract: One‐Pot Synthesis of 4‐Aryl‐2‐cyanoimino‐3,4‐dihydro‐1H‐pyrimidines and Their Reactions.
Authors: Moustafa A. H. , Shestakov A. S. , Shikhaliev Kh. S. 
Published: November 2012

AbstractTitle compounds (IV) are synthesized by a multicomponent Biginelli reaction starting from dicarbonyl compounds (I), aldehydes (II) and cyanamide (III).
ChemInform Abstract: Green and One‐Pot Three‐Component Synthesis of 2,3‐Dihydroquinazolin‐4(1H)‐ones Promoted by Citric Acid as Recoverable Catalyst in Water.
Authors: Ghorbani‐Choghamarani Arash , Taghipour Tahereh 
Published: November 2012

AbstractThe applied catalyst citric acid can be reused several times.
ChemInform Abstract: An Expedient Four‐Component Domino Protocol for the Synthesis of Novel Benzo[a]phenazine Annulated Heterocycles and Their Photophysical Studies.
Authors: Khurana Jitender M. , Chaudhary Ankita , Lumb Anshika , Nand Bhaskara 
Published: November 2012

AbstractA new one‐pot, two‐step domino protocol for the efficient preparation of fluorescent fused benzo[a]phenazine derivatives (20 examples) is described.
ChemInform Abstract: Hydrophosphonylation of Aldimines under Catalysts‐Free Conditions.
Authors: Cai Zhihua , Fan Yecheng , Du Guangfen , He Lin 
Published: November 2012

AbstractHydrophosphonylation of aldimines (I) and (IV) works well, regardless of the nature of groups, the positions of the substituents on the aromatic ring, and the N‐protecting group used.
ChemInform Abstract: Efficient Synthesis of 4‐Halo‐2,5‐dihydro‐1,2‐oxaphosphole 2‐Oxides from 1,2‐Allenylphosphonates and CuX2 and Subsequent Suzuki Cross‐Coupling of the C—Cl Bonds.
Authors: Xin Ning , Ma Shengming 
Published: November 2012

AbstractIn comparison to previous results the advantages of the convenient title synthesis are better functional group tolerance, requirement of fewer steps, and simplicity.
ChemInform Abstract: Core‐extended Rylene Dyes via Thiophene Annulation.
Authors: Li Yan , Xu Wei , Di Motta Simone , Negri Fabrizia , Zhu Daoben , Wang Zhaohui 
Published: November 2012

AbstractPalladium‐catalyzed Stille cross‐coupling of halogenated rylene dyes with thiophene and subsequent ring fusion under Scholl conditions affords core‐extended rylene tetracarboxylic diimides.
ChemInform Abstract: Intramolecular Base‐Free Sonogashira Reaction for the Synthesis of Benzannulated Chiral Macrocycles Embedded in Carbohydrate Templates.
Authors: Hussain Altaf , Yousuf Syed Khalid , Kumar Deepak , Lambu Malikharjunarao , Singh Baldev , Maity Sudip , Mukherjee Debaraj 
Published: November 2012

AbstractA variety of furanoses and pyranoses (14 examples) bearing a bromobenzyl and a terminal alkynyl group undergo the reaction in the presence of a heterogeneous basic alumina‐supported palladium catalyst and CuI as co‐catalyst to give benzannulated 10‐ to 13‐membered macrocycles containing the carbohydrate moiety.
ChemInform Abstract: Heterocycle‐Functional Gramine Analogues: Solvent‐ and Catalyst‐Free Synthesis and Their Inhibition Activities Against Cell Proliferation.
Authors: Ke Shaoyong , Shi Liqiao , Cao Xiufang , Yang Qingyu , Liang Ying , Yang Ziwen 
Published: November 2012

AbstractIndole (I), arylaldehydes (II) and (V), and heteroarylamines (III) or azoles (VI) are appropriate starting materials for the synthesis of gramine analogues (IV) and (VII) by a three‐component condensation reaction.
ChemInform Abstract: Convergent Syntheses of 3,6‐Dihydroxydec‐4‐enolides.
Authors: Killen Jonathan C. , Axford Lorraine C. , Newberry Sarah E. , Simpson Thomas J. , Willis Christine L. 
Published: November 2012

AbstractA Nozaki—Hiyama—Kishi cyclization which creates the (6R) stereocenter in the ring system is the key step in the synthesis of the novel dihydroxy decanolide (Vb) and the known diastereomer (IXb), a constituent of Cordyceps militaris.
ChemInform Abstract: Synthesis and Biological Evaluation of 7‐(2‐Chlorophenylamino)‐5‐((2‐ [18F]fluoro‐ethyoxy)methyl)pyrazolo [1,5‐a]pyrimidine‐3‐carbonitrile as PET Tumor Imaging Agent.
Authors: Qi Chuanmin , et al. et al. 
Published: November 2012

AbstractThe title compound (I) is prepared in a four‐step synthesis with radiochemical purity higher than 98% and radiochemical yields of 25%.
ChemInform Abstract: Synthesis and Biological Evaluation of Novel 2,4,6‐Triazine Derivatives as Antimicrobial Agents.
Authors: Gavade Sandip N. , Markad Vijay L. , Kodam Kisan M. , Shingare Murlidhar S. , Mane Dhananjay V. 
Published: November 2012

AbstractThe three‐step synthesis and the antimicrobial evaluation of triazine salts (I) are given.
ChemInform Abstract: Stereoselective Construction of 5,11‐Methanomorphanthridine and 5,10b‐Phenanthridine Structural Frameworks: Total Syntheses of (.+‐.)‐Pancracine, (.+‐.)‐Brunsvigine, (.+‐.)‐Maritidine, and (.+‐.)‐Crinine
Authors: Pandey Ganesh , Gadre Smita R. 
Published: November 2012

AbstractReview: 107 refs.
Implementing a breast cancer registry and treatment plan/summary program in clinical practice: A pilot program
Authors: Partridge Ann H. , Norris Virginia W. , Blinder Victoria S. , Cutter Bruce A. , Halpern Michael T. , Malin Jennifer , Neuss Michael N. , Wolff Antonio C. ,   on behalf of the ASCO Breast Cancer Registry Pilot Steering Group
Published: November 2012

AbstractBACKGROUND:There is a need to better measure and improve the quality of oncology care and improve communication with patients and other providers. The American Society of Clinical Oncology Breast Cancer Registry (BCR) pilot evaluated the feasibility and acceptability of prospective data collection for quality assessment in daily clinical practice. Data were used to create and share treatment plans/summaries (TPSs) at the point of care.METHODS:Using a web‐based tool, 20 diverse practices entered clinical data on each new early‐stage breast cancer patient into the BCR for 14 months (September 2009 through November 2010). The tool created individual TPSs that were shared with patients. Practices received practice‐specific and aggregate BCR quality measures data, participated in a survey, and received a participation stipend.RESULTS:Twenty practices entered 2014 patients into the BCR, collecting demographic, clinical, and treatment information. Fifty‐two percent of practice participants replied to an end‐of‐pilot survey: 73% were satisfied with the BCR and web‐based tool, 31% expressed concern regarding time and effort, and 52% reported additional practice costs during the pilot. Among those who created or shared the TPSs, 90% thought the documents improved oncologist‐patient communication, and 95% favored using BCR data for practice quality improvement.CONCLUSIONS:Prospective data collection for quality assessment is feasible and allows sharing of TPSs with patients at the point of care. Future efforts should focus on decreasing implementation burden to practices, broadening participation, examining costs, and, most importantly, assessing its effects on patient outcomes. Cancer 2013. © 2012 American Cancer Society.
Theoretical Studies on Muti‐Hydroxyimides as Highly Efficient Catalysts for Aerobic Oxidation
Authors: Chen Kexian , Jia Lu , Dao Rina , Yao Jia , Wang Congmin , Chen Zhirong , Li Haoran 
Published: November 2012

AbstractN,N‐dihydroxypyromellitimide (NDHPI) and N,N′,N′′‐trihydroxyisocyanuric acid (THICA) have been recently demonstrated to act as better carbon‐radical‐producing catalysts than the popular N‐hydroxyphthalimide (NHPI). To gain a mature understanding of these particular catalysts, herein their geometrical, electronic, and thermochemical properties, as well as their catalytic activities, have been systemically investigated by a theoretical analysis. It appears that THICA, unlike NDHPI and NHPI, is unsuitable for solvent‐free catalysis or catalysis in aprotic solvents due to its favorable coexistent planar conformer. Besides, the more remarkable catalytic efficiencies of NDHPI and THICA compared to NHPI can be ascribed to the lower barriers and the endothermicity in the H‐abstraction processes by their radicals, especially by their multi‐radicals which show stronger electron‐withdrawing effects. Furthermore, the generation of THICA radicals would be much feasible at high temperature without co‐catalysts. This study provides a new perspective towards the rational design of reactive hydroxyimide organocatalysts for industrial applications.
Epigenetics in autoimmune diseases with focus on type 1 diabetes
Authors: Dang Mary Ngoc , Buzzetti Raffaella , Pozzilli Paolo 
Published: November 2012

SummaryAutoimmune diseases arise when the body mounts an immune response against ‘self’ cells and tissues causing inflammation and damage. It is commonly accepted that these diseases develop because of the interplay of genetic and environmental factors. Evidence for genetic factors includes the higher concordance of disease in monozygotic twins than in dizygotic twins. However, monozygotic twins may remain discordant for disease indicating a role for environmental factors. Environmental factors may alter gene expression via epigenetic mechanisms. This is particularly pertinent in type 1 diabetes in which DNA methylation and histone modifications have been associated with altered gene expression. The low disease concordance rate in adult‐onset type 1 diabetes (<20%) suggests that environmental and epigenetic changes may play a predominant role. Defining the role of epigenetic changes could identify specific gene pathways and dysregulated expression of gene products that contribute to the pathogenesis of type 1 diabetes. This article reviews how epigenetic mechanisms may contribute to the development of autoimmune diseases with a focus on type 1 diabetes. Copyright © 2012 John Wiley & Sons, Ltd.
Eating disorders after bariatric surgery: A case series
Authors: Conceição Eva , Orcutt Molly , Mitchell James , Engel Scott , LaHaise Kim , Jorgensen Michelle , Woodbury Kara , Hass Naomi , Garcia Luis , Wonderlich Stephen 
Published: November 2012

AbstractObjective:A significant number of post‐bariatric surgery (BS) patients present with eating disorders (EDs) symptoms that require specialized treatment. These cases are thought to be underreported due to their frequent sub‐syndromal presentation. This article describes ED syndromes that develop subsequent to BS.Method:The clinical charts of 12 individuals who were hospitalized on a specialized inpatient EDs unit were reviewed.Results:Based on the new DSM‐5 proposed criteria, six patients would meet criteria for an anorexia nervosa (AN) diagnosis: three with binge eating/purge AN subtype and three with restrictive AN subtype. An additional four met criteria for atypical AN, since they were at a normal weight, and two patients met criteria for bulimia nervosa.Discussion:Several similarities to the classical EDs were found. The findings that most distinguished these patients from those with classical EDs were their ages, and the age of onset of the ED for some patients. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2013)
100 kg more or less, still the same person (and disorder): From overweight to underweight—exacerbation of an eating disorder after bariatric surgery
Authors: Lautenbach Anne , Kulinna Ulrike , Löwe Bernd , Rose Matthias 
Published: November 2012

AbstractObjective:To report the case of a morbidly obese 49‐year‐old woman with nonspecific interstitial pneumonia who underwent bariatric surgery. Because of inadequate weight loss after sleeve gastrectomy, duodenal switch as component of a stepwise treatment was performed and led to unexplained progressive weight loss and malnutrition.Method:Case report.Results:After duodenal switch surgery, the patient presented with late postsurgical symptoms of malabsorption. Postsurgical psychological evaluation revealed a persistent binge eating disorder. Along with exocrine pancreatic insufficiency, binge eating had led to progressive weight loss of ≈100 kg from a body mass index of 50.3 kg/m2 presurgery to 17.3 kg/m2 postsurgery.Discussion:Recent research has focused on eating patterns after bariatric surgery and the risks of exacerbating eating disorders after surgery. This case study illustrates the need for auxiliary prepsychotherapeutic and postpsychotherapeutic evaluation and subsequent support for patients with eating disorders preparing for bariatric surgery. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2013)
Synthesis of Fluorescent Alanines by a Rhodium‐Catalysed Conjugate Addition of Arylboronic Acids to Dehydroalanine Derivatives
Authors: Ferreira Paula M. T. , Monteiro Luís S. , Pereira Goreti , Castanheira Elisabete M. S. , Frost Christopher G. 
Published: November 2012

AbstractSeveral β‐arylalanine derivatives containing fluorescent groups were prepared in good yields using a rhodium‐catalysed conjugate addition of arylboronic acids to N,N‐diprotected and N‐monoprotected dehydroalanines. The best conditions for these reactions required the use of an excess of arylboronic acid (4 equiv.), [Rh(COD)2]BF4 as catalyst, and CsF as base in dioxane/H2O (10:1) at 110 °C. These conditions were also applied to several dipeptides with dehydroalanine residues. The photophysical properties of some of the β‐arylalanines were studied in three solvents with different polarities. Due to the absence of the α,β‐double bond, the absorption and fluorescence emission of the new compounds are dominated by the photophysical properties of the polycyclic aromatic fluorophores (naphthalene, phenanthrene, and pyrene). Considering the relatively high fluorescence quantum yield of these compounds, some of them may be useful as fluorescent markers for peptides and proteins.
Electrochemically Assisted Injection in Combination with Capillary Electrophoresis‐Mass Spectrometry (EAI‐CE‐MS) – Mechanistic and Quantitative Studies of the Reduction of 4‐Nitrotoluene at Various Carbon‐Based Screen‐Printed Electrodes
Authors: Palatzky Peter , Zöpfl Alexander , Hirsch Thomas , Matysik Frank‐Michael 
Published: November 2012

AbstractElectrochemically assisted injection (EAI) is a recently introduced injection concept for capillary electrophoresis (CE) enabling the separation of neutral analytes by means of electrochemical generation of charged species during the injection process. EAI‐CE is particularly attractive in combination with mass spectrometry (MS) leading to enhanced performance of MS detection. In this work, a fully automated EAI injection device was developed and applied to mechanistic and quantitative studies of the reduction of 4‐nitrotoluene (4‐NT). Three different carbon‐based screen‐printed electrodes (SPEs) were used including unmodified carbon, carbon nanofiber and reduced graphene oxide SPEs. Under acidic conditions the main products of 4‐NT reduction were 4‐hydroxylaminotoluene (4‐HAT) and 4‐aminotoluene (4‐AT). The EAI‐CE‐MS approach enabled the separation and selective determination of both compounds. On the basis of this methodical concept it was possible to study the formation of reduction products of 4‐NT in dependence on electrode potential and electrode material. In contrast to conventional electrochemical techniques like cyclic voltammetry EAI‐CE‐MS provides detailed information regarding changes of the product composition in dependence on various experimental conditions. Over the complete potential range studied the ratio of 4‐HAT/4‐AT was clearly different for the reduced graphene oxide SPE compared to the unmodified carbon and carbon fiber SPE. The construction of mass voltammograms added considerably to the information content of voltammetric experiments. Another aspect of this work was the reliable quantitative determination of 4‐NT by EAI‐CE‐MS using isotopically labeled 4‐NT as an internal standard. In this way the “classical” problem of changing response characteristics at solid electrodes could be eliminated based on the assumption that the target analyte and its isotopically labeled form behave in the same way. A corresponding protocol for quantitative EAI‐CE‐MS determinations of 4‐NT was elaborated and applied to standard solutions and spiked soil samples.