bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiviral Effect of Ferula Plants and their Potential for Treatment of COVID-19: A Comprehensive Review
Authors: Mohammadi Raziyeh , Forouzanfar Hasan , Rahimi Hossein , Mohamadi-Zarch Seyed-Mahdi , Jamhiri Khadijah , Bagheri Seyyed Majid 
Published: July 2024

Abstract:
Viral diseases have always been a threat to mankind throughout history, and many
people have lost their lives due to the epidemic of these diseases. In recent years, despite the
progress of science, we are still witnessing a pandemic of dangerous diseases such as COVID-19
all over the world, which can be a warning for humanity. Ferula is a genus of flowering plants
commonly found in Central Asia, and its species have shown antiviral activity against a variety
of viruses, including respiratory syncytial virus, Herpes simplex virus type 1, influenza, human
immunodeficiency virus, hepatitis B, and coronaviruses. In this study, we intend to review the
antiviral effects of Ferula plants, emphasizing the therapeutic potential of these plants in the
treatment of COVID-19. Google, PubMed, Web of Science, and Scopus databases were searched
to review the relevant literature on the antiviral effect of Ferula or its isolated compounds. The
search was performed using the keywords Ferula, antiviral, Coronaviruses, respiratory syncytial
virus, Herpes simplex virus type 1, influenza, human immunodeficiency virus, and hepatitis
B. According to the reviewed articles and available scientific evidence, it was determined that
the plants of this genus have strong antiviral effects. Also, clinical studies have shown that some
species, such as Ferula assa-foetida, can be used effectively in the treatment of COVID-19.
Ferula plants have inhibitory effects on various viruses, making them an attractive alternative to
conventional antiviral agents. Therefore, these plants are a natural source of valuable compounds
that can help us fight infectious diseases.
Development of CDK12 as a Cancer Therapeutic Target and Related Inhibitors
Authors: Chen Biqing , Liu Jiaqi 
Published: July 2024

Abstract:
Cyclin-dependent Kinase 12 (CDK12) is a Cyclin-dependent Kinase (CDK) that plays
a crucial role in various biological processes, including transcription, translation, mRNA splicing,
cell cycle regulation, and DNA damage repair. Dysregulation of CDK12 has been implicated in tumorigenesis,
and genetic alterations affecting CDK12 have been identified in multiple cancer
types, including breast cancer, ovarian cancer, gastric cancer, and prostate cancer. Numerous
studies have demonstrated that suppression of CDK12 expression effectively inhibits tumor
growth and proliferation, underscoring its significance as a cancer biomarker and a potential therapeutic
target in cancer treatment. A thorough comprehension of CDK12 is expected to significantly
enhance the advancement of novel approaches for the treatment and prevention of cancer. In recent
times, endeavors have been undertaken to formulate targeted inhibitors for CDK12, such as
PROTAC and molecular gel degraders. Concurrently, investigations have been conducted on the
combined utilization of CDK12 small molecule inhibitors and immunotherapy as a potential strategy.
This paper examines the diverse functions of CDK12 in the modulation of gene expression
and its implications in human tumors. Specifically, it explores the recently uncovered roles of CDK12
kinases in various cellular processes, emphasizing the potential of CDK12 as a viable therapeutic
target for the management of human tumors. Furthermore, this review provides an up-to--
date account of the advancements made in utilizing CDK12 in tumor therapy.
Arnicolide D Inhibits Proliferation and Induces Apoptosis of Osteosarcoma Cells through PI3K/Akt/mTOR Pathway
Authors: Chen Zhuo , Ni Renhua , Hu Yuanyu , Yang Yiyuan , Tian Yun 
Published: July 2024

Background:
Osteosarcoma is considered as the most prevalent form of primary malignant bone cancer,
prompting a pressing need for novel therapeutic options. Arnicolide D, a sesquiterpene lactone derived from
the traditional Chinese herbal medicine Centipeda minima (known as E Bu Shi Cao in Chinese), showed anticancer
efficacy against several kinds of cancers. However, its effect on osteosarcoma remains unclear.

Objective:
This study aimed to investigate the anticancer activity of arnicolide D and the underlying molecular
mechanism of its action in osteosarcoma cells, MG63 and U2OS.

Methods:
Cell viability and proliferation were evaluated through MTT assay and colony formation assay following
24 h and 48 h treatment with different concentrations of arnicolide D. Flow cytometry was employed to examine
cell cycle progression and apoptosis after 24 h treatment of arnicolide D. Western blotting was performed to
determine the expression of the PI3k, Akt and m-TOR and their phosphorylated forms.

Results:
Our findings revealed that arnicolide D treatment resulted in a significant reduction in cell viability, the
inhibition of proliferation, and the induction of apoptosis and cell cycle arrest in the G2/M phase. Furthermore,
arnicolide D could inhibit the activation of PI3K/Akt/mTOR pathway in osteosarcoma cells.

Conclusion:
Based on our results, arnicolide D demonstrated significant anti-osteosarcoma activity and held the
potential to be considered as a therapeutic candidate for osteosarcoma in the future.
Response Surface Methodology (RSM) for Optimization Carbonization Parameters of Exhausted Coffee Husk for Iron Removal from Aqueous Solution
Authors: Puari Aninda T. , Yanti Nika R. , Sari Nurmala , Rusnam Rusnam 
Published: July 2024

In this study, biochar derived from exhausted coffee husk (ECH) was used as biosorbent for removing Iron (II) from aqueous solution. The aim of this study was to improve the biosorption capacity of the biosorbent from agricultural solid waste and its usability for Fe²⁺ removal. The biosorption performance of ECH biochar was optimized through carbonization parameters: temperature, time, and temperature gradient. Response Surface Methodology (RSM) based on multivariate analysis was employed to evaluate the biosorption performance of ECH biochar for Fe²⁺ biosorption. The optimum performance predicted through Box-Behnken design experiment. The optimal combination of the three parameters was 549.37°C, 1.98 h and 21.98°C/min. At the optimal condition the removal efficiency (RE) was predicted to be 107.01% and biosorption capacity (qt) was 5.11 mg/g. SEM-EDX, FT-IR and XRD analysis were conducted in this study to evaluate the biosorption mechanism of ECH biochar on the iron ion. The results showed that ion exchange existed on the surface of the ECH biochar during the biosorption. Additionally, the presence of functional groups on the ECH biochar surface responsible for Fe(II) binding. Overall, the findings of this study suggested an eco-friendly strategy for optimizing the removal of Iron (II) from polluted water by the biosorption onto ECH biochar. Keywords: Biochar, Biosorption capacity, Box-Behnken design, Temperature, Time
DIGITALISASI PELAYANAN PUBLIK : KETIDAKSIAPAN MASYARAKAT DALAM PENGGUNAAN APLIKASI IDENTITAS KEPENDUDUKAN DIGITAL DI BOJONEGORO
Authors: Siti Marfu'ah  , Ana Kumalasari  , Ida Swasanti  
Published: July 2024

ABSTRAK
Dengan penerapan teknologi digital dalam pelayanan publik, terutama melalui penggunaan aplikasi Identitas Kependudukan digital di Bojonegoro, terdapat banyak pro dan kontra. Dengan menerapkan e-government, pemerintah harus meningkatkan pelayanan publik. Studi kasus Identitas Kependudukan Digital Kabupaten Bojonegoro merupakan salah satu contoh ketidaksiapan masyarakat dalam memasuki era digitalisasi pelayanan publik. Studi ini meningkatkan pemahaman tentang pro dan kontra digitalisasi pelayanan publik, khususnya di Bojonegoro, dan menekankan berbagai masalah yang dihadapi masyarakat. Sukses dalam menerapkan transformasi digital di tingkat lokal bergantung pada kebijakan yang dapat meningkatkan inklusi dan memenuhi kebutuhan masyarakat. Data mining, machine learning, sensor technology, dan service automation merupakan beberapa contoh potensi baru dalam digitalisasi pelayanan publik. Studi kualitatif dengan menggunakan studi kasus Untuk melakukan observasi dan wawancara mendalam dengan para informan di lokasi penelitian, peneliti terjun langsung ke lapangan. Fokus penelitian adalah pada individu yang menggunakan aplikasi IKD khususnya yang tinggal di wilayah Kabupaten Bojonegoro. Hasil penelitian menunjukkan bahwa masyarakat Indonesia, khususnya Bojonegoro, belum siap.

Kata kunci: Digitalisasi; E- goverment; IKD; Ketidaksiapan; Pelayanan publik
ABSTRACT
With the application of digital technology in public services, especially through the use of the IKD application in Bojonegoro, there are many pro and contra. By implementing e-government, the government must improve public services. The Bojonegoro Regency IKD case study is an example of the community's unreadiness to enter the era of digitization of public services. This study increases understanding of the pros and cons of digitizing public services, especially in Bojonegoro, and emphasizes various problems faced by the community. Success in implementing digital transformation at the local level depends on policies that increase inclusion and meet community needs. Data mining, machine learning, sensor technology, and service automation are some examples of new potentials in digitizing public service provision. Qualitative study using case studies To conduct in-depth observations and interviews with informants at the research location, researchers went directly to the field. The focus of the study was on individuals using the IKD application, especially those living in the Bojonegoro Regency area. The study shows that Indonesian society, especially Bojonegoro, is not yet ready.

Keywords: Digitalization; E-government; IKD; Unreadiness; Public service
The Role of Transparency International in Rationalizing Governance and combating Corruption
Authors:   College of Politic Science_Al Nahrain Uni. – Iraq, Isa Abdulrahman , Kadim Ali ,   Presidency of Kerbalaa Uni. -Iraq
Published: July 2024

اذا ما اردنا في بداية البحث ان نعرف منظمة الشفافية الدولية (Transparency International) والتي هي منظمة غير حكومية تهدف إلى تعزيز الشفافية ومكافحة الفساد في جميع مختلف انحاء العالم ، وتعمل تلك المنظمة بمجالات عدة اذ انها تقوم المنظمة بتنفيذ العديد من الأنشطة والمبادرات الهادفة إلى ترشيد الحكم ومكافحة الفساد، وتلعب دورًا هامًا في تعزيز النزاهة والحوكمة في القطاعين العام والخاص ، ويمكن تلخيص البعض من جوانب اساسية في دور منظمة الشفافية الدولية في ترشيد الحكم ومكافحة الفساد واهمها 1.	تقييم العمل ومراقبة اوجه الفساد: اذ انها تعمل على تقييم مستويات الفساد في الدول والعمل على تصنيفها وفقًا لمؤشرات الفساد الدولي الذي تعمل على اصداره بالاعتماد على استطلاعات الرأي وتقارير المؤسسات الدولية، ويوفر صورة عامة عن مستوى الفساد في الدول المختلفة. 2.	تعمل المنظمة على بث و تعزيز الوعي حول الفساد وابراز أثره السلبي على التنمية والمجتمعات ، كما انها تقوم بالدعوة إلى تحسين النظم القانونية والتشريعات المتعلقة بالنزاهة والشفافية، وتشجع على اعتماد معايير دولية لمكافحة الفساد. 3.	السعي الى بناء القدرات: اذ انها تقدم الدعم والتوجيه والمشورة للحكومات والمؤسسات والمجتمع المدني في تعزيز النزاهة وتطوير استراتيجيات مكافحة الفساد، تقوم بتنظيم ورش العمل والدورات التدريبية وتبادل المعرفة والخبرات. 4.	عقد التحالفات والشراكات عبر بناء شراكات قوية مع المؤسسات الحكومية والمنظمات غير الحكومية والقطاع الخاص ووسائل الإعلام والأفراد المهتمين بمكافحة الفساد تعزز المنظمة التعاون الدولي وتبادل المعلومات والأفكار لتعزيز جهود مكافحة الفساد. نشر الشفافية والنزاهة و تعزيز ثقافة الشفافية والنزاهة في القطاعين العام والخاص عبر تشجيع الاعتماد على الممارسات الشفافة وتعزيز حق الوصول إلى المعلومات والرقابة المستقلة
Urbanismo con perspectiva de género
Authors: Castañeda Miguel Alejandro , Gimelfarb Leonor Selena , Cordero Robles María Rosa , Valletto Marcela Beatriz , Torres Pagnussat Leticia , Millicay Selva Yanina 
Published: July 2024

Este texto se propone esbozar el estado de la cuestión en torno a la relación entre urbanismo y perspectiva de énero presentando algunos rasgos característicos de su desarrollo en el contexto local (regional y nacional). El urbanismo con perspectiva de género comienza dentro de una tradición europea y norteamericana y exhibe, a partir de allí, una expansión teórica y práctica más allá de ese contexto original. Uno de esos nuevos escenarios en los que se despliega esta perspectiva del urbanismo es el de América Latina y Argentina. Especialmente atendiendo a esto último, la propuesta de este trabajo es (i) caracterizar el urbanismo con un enfoque de género; (ii) identificar algunos de los factores condicionantes más significativos para el surgimiento de esta peculiar imbricación; y (iii) delimitar algunos rasgos de la instanciación de este nuevo perfil del urbanismo en el contexto de la región y del país.
Selected Research Issues of Prototype Floating Systems
Authors: Derewońko Agnieszka , Krasoń Wiesław 
Published: July 2024

Abstract
The paper presents a solution that can be used as a temporary supplement to the existing infrastructure in cases of natural disasters, during structure or bridge repair, in military applications and in areas where it is necessary to provide a floating system crossing. The genesis of the proposed structure and its development, as well as examples of applications of the basic module, referred to as the river module – the floating cassette with the pneumatic pontoon – are presented. The original solutions, such as the bow–stern modules, designed using modern, light and durable materials acting as deflectors, are also described. Examples of the use of floating structures composed of identical/repeatable modules–cassettes are shown. The results of experimental tests of two prototype river modules sets are presented as a validation for numerical studies. Selected aspects of static, kinematic and dynamic analyses using finite element and multibody simulations are presented. The numerical simulation of the prototype floating bridge with an assessment of the impact of clearances and an estimation of the kinematic parameters of the floating ribbon with various configurations are described.
Self-Regulation of Property Civil Relations With the Participation of State-Owned Enterprises: Shortcomings of the Soviet Approach
Authors: Vasyliev Vladyslav 
Published: July 2024

Abstract
The article examines the peculiarities of the exercise of freedom of contract and freedom of entrepreneurial activity by state-owned enterprises in the USSR under the conditions of the state monopoly in the production of property goods, planned regulation of production and administrative-command economy in general.
The author examines certain historical aspects of the formation of state-owned enterprises as subjects of property relations on the basis of state-owned industries. The article highlights the problems of granting state-owned enterprises with civil legal personality and their participation in property turnover within the framework of the concept of economic calculation, the impact of the planned approach on the scope of freedom of contract and freedom of entrepreneurship of state-owned enterprises in the course of their activities. The author determines the correlation between the plan and the contract as means of regulating property relations and outlines the functions of the contract in the property turnover of the USSR.
Aristotle’s Notion of Deduction
Authors: Vlasáková Marta 
Published: July 2024

Abstract
Aristotle’s notion of deduction (syllogism) differs from the conception of logical consequence in classical logic in two essential features, which are required by Aristotle’s definition of syllogism and are incorporated into his formalisation of deduction: in addition to the standard necessary truth-preservation, Aristotle requires relevance of premises for the conclusion and non-repetition of premises in the conclusion. These requirements, together with Aristotle’s conception of simple propositions, lead to the result that valid deductive steps (syllogisms) must have very specific forms, namely the well-known syllogistic shape. All other kinds of deduction lacking this shape, such as “syllogisms based on a hypothesis”, can be considered “syllogisms” only in a relative sense: they are based on an assumption of the existence of genuine syllogistic deductions in the syllogistic shape. Aristotle’s demands should cover all kinds of deduction: all valid deduction must be relevant and non-repetitive. This brings Aristotle’s definition much closer to the intuition associated with the notion of logical consequence.
Determining the Influence of Curing Temperature and SCMs on C-A-S-H Composition Using SEM-EDS Hypermaps
Authors: Hemstad Petter , Kjellemyr Petter , Weerdt Klaartje De 
Published: July 2024

Abstract
Calcium-alumina-silicate-hydrate (C-A-S-H) is the main hydration product formed in Portland composite cement pastes. C-A-S-H is a key phase with regard to the strength and durability of concrete. Proper characterization of C-A-S-H is difficult due to intermixing with other phases, thus limiting the applicability of point scan analyses using scanning electron microscopy (SEM). Recent advances have enabled the use of hypermaps from energy dispersive spectroscopy (EDS) to investigate hydrate phases with better statistics. This study investigated how increased curing temperature and the inclusion of pozzolanic SCMs change the composition of the C-A-S-H, using the edxia plugin and SEM-EDS hypermaps. Composite cement pastes were cured at 20, 38, and 60°C for 180 days before analysis. We discuss the interpretation of the data from hypermaps in comparison to the traditional point scan approach.
Penerapan Prinsip Eko-Arsitektur pada Redesain dan Relokasi Pasar Tradisional Kota Panton Labu
Authors: Anggraini Anggi Pusfita , Nursaniah Cut , Haiqal Muhammad 
Published: July 2024

Pasar tradisional merupakan salah satu aspek yang berperan penting dalam mendongkrak pertumbuhan dan perkembangan di suatu daerah maupun perkotaan. Kota Panton Labu sendiri merupakan kota dengan pelayanan perdagangan skala regional yang merupakan sumber Pendapatan Asli Daerah (PAD) kabupaten Aceh Utara dalam bidang perdagangan dan jasa. Letak strategis kota Panton Labu juga merupakan jalur utama lintas Sumatra yang mempermudah akses sirkulasi kontribusi pemasaran barang, oleh karena itu Pasar Tradisional kota Panton Labu menjadi pusat pasar sentral dan pusat perputaran ekonomi dalam segi pelayanan perdagangan dari beberapa kecamatan yang berada di sekitarnya. Kota Panton Labu untuk ke depannya juga akan menjadi pusat kota dan sebagai pusat sentral pembangunan ekonomi sekaligus pembangunan kota Daerah Otonomi Baru (DOB) dari beberapa kecamatan. Peran ekologi sendiri sebagai ilmu interaksi antara makhluk hidup serta menyelaraskan hubungan dengan lingkungan alam merupakan tema yang sangat cocok diterapkan pada bangunan pasar, di mana hubungan antara makhluk hidup dengan lingkungan yang terjadi dalam aktivitas sebuah pasar sangat besar kaitannya, mulai dari pencemaran lingkungan dan kenyamanan pengguna terhadap bangunan sendiri. Pendekatan prinsip Eko-Arsitektur diimplementasikan pada sistem pengolahan air, tanah, udara, penanganan limbah dan efisiensi dalam penggunaan energi pada pasar yang menciptakan bangunan pasar tradisional ramah lingkungan, tidak mencemari lingkungan dan mengoptimalkan kenyamanan penggunanya, sehingga fungsi pasar berjalan dengan sangat baik untuk ke depannya.
Arsitektur Kontemporer dalam Perancangan Hotel Resort di Pantai Iboih, Sabang
Authors: Rihanna Rihanna , Ariatsyah Ardian , Priandi Riza 
Published: July 2024

Aceh merupakan salah satu provinsi Indonesia yang terletak sebelah barat Sumatra. Aceh memiliki tempat wisata alam yang sangat banyak diminati oleh wisatawan. Salah satu tempat wisata yang sangat diminati berada di Kota Sabang yaitu Pantai Iboih yang berkarateristik pantai berpasir dan berkarang indah yang menjadi daya tarik bagi wisatawa, Pantai Iboih juga berhadapan dengan Pulau Rubiah yang merupakan pulau destinasi bagi parawisata untuk melakukan snorkelling dan hal seru lainnya. Dengan adanya peningkatan jumlah pariwisata setiap tahunnya, maka perlu adanya sarana untuk penginapan hotel resort yang memiliki standard bintang 5 dengan fasilitas yang terpenuhi. Perancangan hotel resort pada kawasan Pantai Iboih untuk memberikan fasilitas kepada parawisata yang ingin bermalam di Pantai Iboih. Pada era berkembang saat ini banyak muncul berbagai konsep tema arsitektur, agar fasad yang didesain pada hotel resort dapat menampilkan kesan yang menarik dan nyaman bagi wisatawan maka dalam perancangan ini menerapkan konsep arsitektur kontemporer baik pada interior maupun eksterior bangunan dengan penekanan rancangan yang menggunakan warna-warna netral sesuai dengan standard konsep arsitektur kontemporer. Arsitektur kontemporer adalah arsitektur yang memiliki kebebasan untuk berekspresi dan berkreasi, dapat menampilkan suatu yang berbeda dari aliran terbaru. Diharapkan dengan adanya hasil rancangan hotel resort di Pantai Iboih dapat mendukung fasilias bagi wisatawan dan menjadikan rancangan sebagai tempat wisata.
SOSIALISASI GOOD FARMING PRACTICE (GMP) PADA PETERNAKAN SAPI POTONG DI DESA REUDEUP KECAMATAN MONTASIK KABUPATEN ACEH BESAR
Authors: Pratama Said Mirza , Sriwati Rina , Ferasyi Teuku Reza , Nasrullah Nasrullah , Resthu Muhammad , Samadi Samadi 
Published: July 2024

Salah satu ternak penghasil daging yang memiliki nilai ekonomis tinggi adalah sapi potong. Secara umum peternakan sapi potong masih dikelola secara tradisional oleh masyarakat, sehingga terdapat banyak problematika dalam pengembangannya. Mitra pada kegiatan ini adalah kelompok ternak Al-Falah yang berada di Desa Reudeup, Kecamatan Montasik, Kabupaten Aceh Besar. Permasalahan yang dihadapi peternak adalah rendahnya produktivitas ternak, ketersediaan pakan, kualitas pakan yang rendah, dan masalah lainnya. Solusi dari permasalahan tersebut adalah penerapan Good Farming Practice (GMP) di atur dalam Peraturan Menteri Pertanian Republik Indonesia Nomor 46/Permentan/PK.210/8/2015 tentang Budidaya Sapi Potong yang Baik. Kegiatan sosialisasi ini bertujuan untuk meningkatkan kualitas sumber daya manusia melalui peningkatan pengetahuan peternak sapi potong terkait dengan penerapan Good Farming Practice (GMP) pada peternakan sapi potong. Kegiatan ini dilakukan di Desa Reudeup Kecamatan Montasik Kabupaten Aceh Besar pada bulan November 2022. Kegiatan ini mendapat respon yang sangat baik serta antusiasme dari peterak, ditandai dengan minat peternak untuk bertanya dan permintaan peternak agar desa Reudeup dijadikan desa binaan sehingga memudahkan akses untuk mendapatkan bimbingan teknis teknologi peternakan yang berkesinambungan. Kesimpulan dari kegiatan pengabdian ini adalah para peternak di kelompok ternak Al-Falah Desa Reudeup Kecamatan Montasik Kabupaten Aceh Besar telah memiliki pengetahuan yang baik terkait penerapan Good Farming Practice (GMP) hal ini ditandai dengan meningkatnya nilai peternak saat dilakukan evaluasi. Peternak mempunyai komitmen untuk menerapkan materi yang telah disampaikan sesuai dengan materi yang disampaikan oleh pemateri.