bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice
Authors: Nagura Hitoshi , Ishikawa Yasuyuki , Kobayashi Katsunori , Takao Keizo , Tanaka Tomo , Nishikawa Kouki , Tamura Hideki , Shiosaka Sadao , Suzuki Hidenori , Miyakawa Tsuyoshi , Fujiyoshi Yoshinori , Doi Tomoko 
Published: December 2012

Abstract

Background
Postsynaptic density (PSD)-95-like membrane-associated guanylate kinases (PSD-MAGUKs) are scaffold proteins in PSDs that cluster signaling molecules near NMDA receptors. PSD-MAGUKs share a common domain structure, including three PDZ (PDZ1/2/3) domains in their N-terminus. While multiple domains enable the PSD-MAGUKs to bind various ligands, the contribution of each PDZ domain to synaptic organization and function is not fully understood. Here, we focused on the PDZ1/2 domains of PSD-95 that bind NMDA-type receptors, and studied the specific roles of the ligand binding of these domains in the assembly of PSD proteins, synaptic properties of hippocampal neurons, and behavior, using ligand binding-deficient PSD-95 cDNA knockin (KI) mice.

Results
The KI mice showed decreased accumulation of mutant PSD-95, PSD-93 and AMPA receptor subunits in the PSD fraction of the hippocampus. In the hippocampal CA1 region of young KI mice, basal synaptic efficacy was reduced and long-term potentiation (LTP) was enhanced with intact long-term depression. In adult KI mice, there was no significant change in the magnitude of LTP in CA1, but robustly enhanced LTP was induced at the medial perforant path-dentate gyrus synapses, suggesting that PSD-95 has an age- and subregion-dependent role. In a battery of behavioral tests, KI mice showed markedly abnormal anxiety-like behavior, impaired spatial reference and working memory, and impaired remote memory and pattern separation in fear conditioning test.

Conclusions
These findings reveal that PSD-95 including its ligand binding of the PDZ1/2 domains controls the synaptic clustering of PSD-MAGUKs and AMPA receptors, which may have an essential role in regulating hippocampal synaptic transmission, plasticity, and hippocampus-dependent behavior.
4-Aryl-4H-naphthopyrans derivatives: one-pot synthesis, evaluation of Src kinase inhibitory and anti-proliferative activities
Authors: Rafinejad Ali , Fallah-Tafti Asal , Tiwari Rakesh , Shirazi Amir Nasrolahi , Mandal Deendayal , Shafiee Abbas , Parang Keykavous , Foroumadi Alireza , Akbarzadeh Tahmineh 
Published: December 2012

AbstractBackgroundA series of 2-amino-4-aryl-4H-benzo[h or f]chromene-3-carbonitrile derivatives were synthesized and evaluated for inhibition of Src kinase and cell proliferation in breast carcinoma (BT-20) cell lines.MethodsThe one-pot, three-component reaction of α or β-naphthol, malonitrile and an aromatic aldehyde in the presence of diammonium hydrogen phosphate was afforded the corresponding 2-amino-4-aryl-4H-benzo[h or f]chromene-3-carbonitrile derivatives, All target compounds were evaluated for inhibition of Src kinase and cell proliferation in breast carcinoma (BT-20) cell lines.ResultsAmong all tested compounds, unsubstituted 4-phenyl analog4ashowed Src kinas inhibitory effect with IC50value of 28.1 μM and was the most potent compound in this series. In general, the compounds were moderately active against BT-20. 3-Nitro-phenyl4eand 3-pyridinyl4hderivatives inhibited the cell proliferation of BT-20 cells by 33% and 31.5%, respectively, and found to be more potent compared to doxorubicin (25% inhibition of cell growth).ConclusionThe data indicate that 4-aryl-4H-naphthopyrans scaffold has the potential to be optimized further for designing more potent Src kinase inhibitors and/or anticancer lead compounds.
Differential analysis of high-throughput quantitative genetic interaction data
Authors: Bean Gordon J , Ideker Trey 
Published: December 2012

AbstractSynthetic genetic arrays have been very effective at measuring genetic interactions in yeast in a high-throughput manner and recently have been expanded to measure quantitative changes in interaction, termed 'differential interactions', across multiple conditions. Here, we present a strategy that leverages statistical information from the experimental design to produce a novel, quantitative differential interaction score, which performs favorably compared to previous differential scores. We also discuss the added utility of differential genetic-similarity in differential network analysis. Our approach is preferred for differential network analysis, and our implementation, written in MATLAB, can be found at http://chianti.ucsd.edu/~gbean/compute_differential_scores.m.
Quantification of Negative Aesthetic Ratings in Primary Unrepaired Unilateral Cleft Lip Infants by Modified Paired Comparison Method
Authors: Uchiyama Takeshi , Kitamura Nobutaka , Watanabe Akira , Suga Ken-Ichiro , Nakano Yoko , Hitoshi Ohhata , Takagiwa Mutsumi 
Published: December 2012

Objective To quantify negative aesthetic ratings in primary unrepaired cleft lip infants by further refining our previously reported paired comparison method. Design The Thurstone paired comparison method was used to quantify negative aesthetic ratings of plaster facial models selected and ordered according to a table of paired random numbers. Patients, Participants A total of 30 facial models of unrepaired incomplete unilateral cleft lip infants were used in this study. Raters comprised 20 oral surgeons and anesthesiologists. Results Quantification of aesthetic ratings for the 30 face models of unrepaired incomplete unilateral cleft lip infants was obtained. The ratings ranged from 0 to 5.08. Conclusion Quantification of the aesthetic ratings for the 30 face models will be used as objective variables in a multivariate analysis in the third stage of this ongoing study.
Lex necessitatis vel contingentiae
Authors: Porro Pasquale 
Published: December 2012

Lex necessitatis vel contingentiae Cet article se propose de reconsidérer de manière critique deux présupposés spécifiques à l’interprétation gilsonienne de Thomas d’Aquin : (i) le fait que, dans l’univers thomasien, tous les étants différents de Dieu soient marqués par une « contingence radicale » ; (ii) l’idée qu’en dernière analyse cette contingence est fondée sur la distinction entre être et essence – et, plus généralement, (iii) la conviction que la conception thomiste de la providence se présente comme une alternative radicale au déterminisme et au nécessitarisme de la tradition gréco-arabe. À cette fin, nous examinerons successivement les points suivants : les significations les plus communes que Thomas confère aux notions de nécessité et de contingence ; le rapport entre fortune, sort et providence ; la réfutation conditionnée du déterminisme astral ; le mode sur lequel la providence dispose les événements nécessaires aussi bien que les événements contingents ; les réactions opposées de Siger de Brabant et de Jean Duns Scot au modèle par lequel Thomas tente de sauver la contingence au sein de l’ordre providentiel ; l’affirmation par Thomas de l’existence de créatures formellement nécessaires. En conclusion, on suggère que Thomas affaiblit certains présupposés fondamentaux de la stratégie anti-déterministe mise en œuvre par Aristote dans le livre VI de la Métaphysique , que l’alternative entre nécessité et contingence ne représente pas chez Thomas le véritable départ entre le créateur et la créature, et que, pour cette raison, la distinction entre être et essence n’a pas pour premier et principal objectif de rendre compte de la contingence de tous les étants créés.
Le jeune Sartre et le vieux Sertillanges : le chassé-croisé de la création
Authors: Clavier Paul 
Published: December 2012

Résumé Sans tomber dans le piège des débats pseudo-scientifiques sur l’entropie de l’univers ou la cosmologie de « l’atome primitif », Sartre et Sertillanges font tous les deux un sort au véritable concept métaphysique de création, c’est-à-dire le concept de dépendance ontologique. Tandis que Sartre nie que le créé puisse avoir la moindre consistance propre tant qu’il dépend d’un créateur, Sertillanges inverse la donne en affirmant que c’est parce que le créé a une consistance propre qu’il peut être dit dépendre d’un créateur. Deux réponses symétriques formulées dans un schème conceptuel presque commun.
La représentation selon Voegelin, ou les deux visages de Hobbes
Authors: Karsenti Bruno 
Published: December 2012

Résumé Placée sous le signe d’une restauration de la science politique pour l’époque moderne, la pensée de Voegelin tourne autour du concept de représentation, dont elle renouvelle complètement le sens en le reconduisant aux conditions d’existence d’une société politique. On peut estimer que la confrontation avec la théorie hobbesienne de la personne civile en est l’épicentre. Cet essai s’efforce de restituer cette confrontation, en faisant ressortir l’ambivalence sur laquelle elle repose : le double visage de Hobbes, jugé d’un côté responsable de la théorie abstraite de la représentation qui triomphe depuis le xvii e siècle, de l’autre résistant héroïque au déclin spirituel de la modernité, s’efforçant de forger un nouveau corpus mysticum dans un contexte où l’institution ecclésiale ne joue plus le rôle de garant. Plus radicalement, à travers la lecture voegelinienne de Hobbes, c’est le sens de ce que le christianisme fait subir à l’ épistémé politiké classique qui est soumis à l’examen. En reconstituant cette lecture, on fait apparaître pour finir les difficultés sur lesquelles Voegelin vient buter, dans la tâche restauratrice qu’il assigne à la pensée moderne tout entière.
Advancing the Educational and Career Pathway for Clinical Trials Nurses
Authors: Scott Kathleen , White Kathryn , Roydhouse Jessica K. 
Published: December 2012

Clinical trials nurses play a pivotal role in the conduct of clinical research, but the educational and career pathway for these nurses remains unclear. This article reports findings from a survey of nurses working in cancer clinical trials research in Australia. Most participants held postgraduate qualifications (42 of 61); however, clinical trials education was primarily attained through short professional development courses. Interest in pursuing trial-specific postgraduate education was high, but barriers were identified, including cost, time, and unclear benefit for career advancement. Job titles varied substantially, which is indicative of an unclear employment pathway. These findings suggest that initiatives to improve the educational and career pathway for clinical trials nurses are needed and should include the following: formal educational preparation, greater consistency in employment status, and clearer career progression. These strategies should be underpinned by broad professional recognition of the clinical trials nurse as a specialized nursing role.J Contin Educ Nurs2013;44(4):165–170.
Nursing Grand Rounds: The North Queensland, Australia, Experience
Authors: Smyth Wendy , Abernethy Gail 
Published: December 2012

How to Obtain Contact Hours by Reading this Issue

Instructions: 1.1
contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz.

A contact hour certificate will be awarded once you register, pay the registration fee, and complete the evaluation form online at
https://villanova.gosignmeup.com
.

In order to obtain contact hours you must:

1.
Read the article, “Nursing Grand Rounds: The North Queensland, Australia, Experience,” found on pages 203–208, carefully noting any tables and other illustrative materials that are included to enhance your knowledge and understanding of the content. Be sure to keep track of the amount of time (number of minutes) you spend reading the article and completing the quiz.

2.
Read and answer each question on the quiz. After completing all of the questions, compare your answers to those provided within this issue. If you have incorrect answers, return to the article for further study.

3.
Go to the Villanova website to register for contact hour credit. You will be asked to provide your name, contact information, and a VISA, MasterCard, or Discover card number for payment of the $20.00 fee. Once you complete the online evaluation, a certificate will be automatically generated.

This activity is valid for continuing education credit until
April 30, 2015.

Contact Hours
This activity is co-provided by Villanova University College of Nursing and SLACK Incorporated.
Villanova University College of Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.

Objective

Upon completion of this article, the learner will describe key logistical considerations in the establishment of an institutional nursing grand rounds program in Queensland, Australia.

Disclosure Statement
Neither the planners nor the authors have any conflicts of interest to disclose.

There are multiple opportunities and options to improve nurses’ engagement with research and evidence-based practice. Nursing grand rounds, in their various guises, are one such initiative. A large regional health service in North Queensland, Australia, introduced nursing grand rounds in late 2010 as a professional development activity. This article discusses the success of the initiative, as evaluated by the attendees and as assessed by members of the organizing group. One notable aspect of the initiative is that it allows both nurses working in small rural and remote facilities and nurses working in the regional city to participate in the presentations. Aspects of the initiative that require continued consideration to ensure the sustainability of nursing grand rounds are identified.

J Contin Educ Nurs
2013;44(5):203–208.
Educational Strategies for Rural New Graduate Registered Nurses
Authors: Dowdle-Simmons Sara 
Published: December 2012

How To Obtain Contact Hours By Reading This Issue

Instructions: 1.1
contact hours will be awarded by Villanova University College of Nursing upon successful completion of this activity. A contact hour is a unit of measurement that denotes 60 minutes of an organized learning activity. This is a learner-based activity. Villanova University College of Nursing does not require submission of your answers to the quiz.

A contact hour certificate will be awarded once you register, pay the registration fee, and complete the evaluation form online at
https://villanova.gosignmeup.com
.

In order to obtain contact hours you must:

1.
Read the article, “Educational Strategies for Rural New Graduate Registered Nurses,” found on pages 107–110, carefully noting any tables and other illustrative materials that are included to enhance your knowledge and understanding of the content. Be sure to keep track of the amount of time (number of minutes) you spend reading the article and completing the quiz.

2.
Read and answer each question on the quiz. After completing all of the questions, compare your answers to those provided within this issue. If you have incorrect answers, return to the article for further study.

3.
Go to the Villanova website to register for contact hour credit. You will be asked to provide your name, contact information, and a VISA, MasterCard, or Discover card number for payment of the $20.00 fee. Once you complete the online evaluation, a certificate will be automatically generated.

This activity is valid for continuing education credit until
February 28, 2015
.

Contact Hours
This activity is co-provided by Villanova University College of Nursing and SLACK Incorporated.
Villanova University College of Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.

Objective

Upon completion of this article, the learner will have reviewed concepts and educational strategies for rural new graduate registered nurses.

Disclosure Statement
Neither the planners nor the author have any conflicts of interest to disclose.

Rural health care facilities are geographically remote, tend to be small, and often possess limited resources. Although newly graduated registered nurses are important to the work force of many rural communities, maintaining a formal preceptorship/mentorship program within a rural hospital may prove difficult as a result of limited resources. Unfortunately, the new graduate may become overwhelmed by the many expectations for clinical practice and the facility can experience high turnover rates of new graduate hires. This article explores the unique traits of the rural hospital and the new graduate nurse as well as the pros and cons of a formal preceptorship program within a rural setting. Constructivist learning theory is used to develop practical teaching strategies that can be used by the preceptor and the new graduate. These strategies are inexpensive, yet effective, and are feasible for even the smallest of facilities.
Protective Eyewear Use as Depicted in Children’s Television Programs
Authors: Korchak Michael E. , Glazier Robert U. , Slack Rebecca S. , Plankey Michael W. , Mayer Hylton R. 
Published: December 2012

Purpose:
To characterize the depiction of protective eyewear use in scripted children’s television programs.

Methods:
Viewership ratings data were acquired to generate a list of the most-watched scripted broadcast and cable programs for the 2- to 12-year-old age group. The three highest average viewership programs from broadcast and cable programming that met the inclusion criteria were analyzed by two independent reviewers.

Results:
Review of 30 episodes revealed a total of 244 exposure-scenes in which an individual was engaged in an activity requiring eye protection. There were 5.5 (mean = 8.1) exposure-scenes per episode, with 26 of 30 (87%) episodes containing at least one exposure-scene. There were 19 depictions of protective eyewear use (8% of total exposure-scenes). Fifteen of the 19 cases of protective eyewear use occurred on broadcast programming. Six eye injuries were depicted in the media content.

Conclusion:
The depiction of protective eyewear use during eye-risk activities is rare in scripted children’s television programs and eye injuries are rarely depicted.

[J Pediatr Ophthalmol Strabismus 2013;50:118–123.]
Thoracic Exploration for Mediastinal Parathyroids requires a Multidisciplinary Approach
Authors: Milas Mira , Siperstein Allan , Mitchell Jamie C , Berber Eren , Shin Joyce , Rice Thomas , Mihaljevic Tomislav , Mason David 
Published: December 2012

ABSTRACT
Mediastinal parathyroid disease requiring a thoracic surgical approach is a rare and challenging clinical entity. The objective of this study was to review our experience treating these patients, highlighting the importance of a multidisciplinary approach. Seven patients required a thoracic approach for mediastinal parathyroid disease between 1999 and 2010. All patients achieved biochemical cure with varying combinations of preoperative and intraoperative localizing studies interpreted by a multidisciplinary team, including radiologists, thoracic and endocrine surgeons, being required in each patient.

How to cite this article
Mitchell JC, Milas M, Berber E, Siperstein A, Shin J, Rice T, Mihaljevic T, Mason D. Thoracic Exploration for Mediastinal Parathyroids requires a Multidisciplinary Approach. World J Endoc Surg 2012;4(3): 87-92.
Dual Localization with Ultrasound and Iodine 123 and Technetium (99mTc) Sestamibi Scintigraphy is Superior to Single Imaging Modalities in Facilitating Minimally Invasive Parathyroidectomy for Primary Hyperparathyroidism
Authors: Lyon Alison , Komolafe Olusegun O , Wilson Christopher R , Doughty Julie C 
Published: December 2012

ABSTRACT
Primary hyperparathyroidism is caused by a single parathyroid adenoma in the majority of patients. Localization of parathyroid adenomas prior to surgery has the benefit of allowing a minimally invasive approach. Over the years, multiple imaging modalities have been employed in an attempt to identify the site preoperatively, with varying degrees of success. In this study, we explore the accuracy of a combination of ultrasound and nuclear medicine planar scintigraphy with iodine-123 and technetium (99mTc) sestamibi. A retrospective study of consecutive series of 117 patients undergoing minimally invasive parathyroidectomy was carried out. Inclusion criteria incorporated clinical and biochemical evidence of primary hyperparathyroidism. All patients had at least one form of imaging: Ultrasound or nuclear medicine scintigraphy or both. The accuracy was compared with surgical findings. Gland weight was also related to imaging accuracy. A total of 101 patients underwent surgery for primary hyperparathyroidism. There was no significant difference between ultrasound and scintigraphy ability to localize a parathyroid adenoma (p = 0.738). The combination of ultrasound and scintigraphy was superior at preoperative localization compared to ultrasound (p = 0.039) or scintigraphy alone (p = 0.0078). Gland weight had no significant bearing on the accuracy of the scan (ultrasound, p = 0.89; scintigraphy, p = 0.16). Dual localization with ultrasound and scintigraphy in primary hyperparathyroidism is superior to a single imaging technique. Dual localization facilitates minimally invasive parathyroidectomy.

How to cite this article
Lyon A, Komolafe OO, Wilson CR, Doughty JC. Dual Localization with Ultrasound and Iodine 123 and Technetium (99mTc) Sestamibi Scintigraphy is Superior to Single Imaging Modalities in Facilitating Minimally Invasive Parathyroidectomy for Primary Hyperparathyroidism. World J Endoc Surg 2012;4(3):93-98.
Bilateral Pheochromocytoma in von Hippel-Lindau Syndrome Simultaneously Removed by Lateral Retroperitoneal Endoscopic Approach
Authors: Todorov Georgi , Grozdev Konstantin , Lukanova Tsonka , Mioljevikj-Miserliovska Biljana , Miserliovski Risto 
Published: December 2012

ABSTRACT
Von Hippel-Lindau (VHL) syndrome is an autosomal dominant familial neoplastic syndrome caused by mutation in VHL tumor suppressor gene localized on chromosome 3p25. The disease is characterized by abnormal vascular proliferation and increased risk of developing renal cell carcinoma, pheochromocytoma, hemangioblastoma of the central nervous system, tumors of the endolymphatic bag, cysts of the kidney, liver and pancreas, epididymal cystadenomas, neuroendocrine tumors of the pancreas, angiomas in the retina. We report a case of a bilateral pheochromocytoma, simultaneously removed by unilateral total and contralateral subtotal retroperitoneal endoscopic adrenalectomy.

How to cite this article
Todorov G, Grozdev K, Lukanova T, Mioljevikj-Miserliovska B, Miserliovski R. Bilateral Pheochromocytoma in von Hippel-Lindau Syndrome Simultaneously Removed by Lateral Retroperitoneal Endoscopic Approach. World J Endoc Surg 2012;4(3):102-104.
Nonrecurrent Laryngeal Nerve: A Case Report and a Review of an Important Anatomical Variant
Authors: Sukharamwala Prashant , Korbin Seth , Ghani Abdul , Smith James 
Published: December 2012

ABSTRACTAn important anatomical structure commonly encountered during major head and neck surgery is the recurrent inferior laryngeal nerve. Nonrecurrent inferior laryngeal nerve variants are rarely encountered. Although much less common, these variants represent a significant risk for intraoperative nerve injury and patient morbidity. We present a case of a right nonrecurrent inferior laryngeal nerve variant along with a retrospective analysis and systematic review investigating the overall incidence of these variants.How to cite this articleSukharamwala P, Korbin S, Ghani A, Smith J. Nonrecurrent Laryngeal Nerve: A Case Report and a Review of an Important Anatomical Variant. World J Endoc Surg 2012;4(3):112-114.