bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kreativität bei Kindern und Jugendlichen mit Asperger Syndrom
Authors: Weiss Elisabeth M. , Gschaidbauer Bianca , Kaufmann Liane , Papousek Ilona , Fink Andreas 
Published: December 2013

Das Ziel der vorliegenden Studie war die systematische Erfassung der Kreativitätsleistung bei 5- bis 14-jährigen Jungen mit Asperger Syndrom im Vergleich mit einer gesunden Kontrollgruppe (je n=24). Untersucht wurden sowohl quantitative Kreativitätsaspekte (Ideenflüssigkeit, Ideenflexibilität) als auch qualitative Kreativitätsaspekte (Originalität) bei zwei Altersgruppen (jüngere Kinder: 5 – 9 Jahre, ältere Kinder/Jugendliche: 10 – 14 Jahre). Die Ergebnisse zeigen, dass bei Kindern/Jugendlichen mit Asperger Syndrom primär die quantitativen Aspekte der Kreativität beeinträchtigt sind (Ideenflüssigkeit und -flexibilität bei gleichbleibenden Items aus dem 5-Punkte Test), während die Kreativitätsleistung bei den abwechslungsreicheren Bildergänzungsaufgaben des Torrance Test of Creative Thinking, bei denen die Qualität/Originalität im Vordergrund steht, unbeeinträchtigt ist. In unserer Stichproben waren die Alterseffekte signifikant (jüngere Kinder zeigten schlechtere Leistungen), aber über die Gruppen vergleichbar (d. h. die Interaktionseffekte waren nicht signifikant). Im Sinne einer ressourcenorientierten Diagnostik, die für eine maßgeschneiderte Interventionsplanung unerlässlich ist, sollten also zusätzlich zu den quantitativen auch die qualitativen Aspekte kreativer und exekutiver Denkleistungen erfasst werden.
Verhaltensprobleme bei Kindern mit umschriebener und kombinierter schulischer Minderleistung
Authors: Endlich Darius , Dummert Friederike , Schneider Wolfgang , Schwenck Christina 
Published: December 2013

Ziel der vorliegenden Studie war es, den Zusammenhang zwischen Lerndefiziten und Verhaltensproblemen nachzuweisen und näher zu untersuchen. Aus einer Ausgangsstichprobe von N = 929 Kindern wurde zu Beginn der zweiten Jahrgangsstufe eine Zielstichprobe von N = 94 Kindern identifiziert, die eine Lese-/Rechtschreibschwäche (LRS), eine Rechenschwäche (RS), eine kombinierte Schwäche (KOM) oder keine Schwäche (KG) aufwiesen. Diese Kinder wurden bis zur Mitte der vierten Jahrgangsstufe längsschnittlich untersucht. Verhaltensprobleme wurden über das Elternurteil (CBCL) zu Beginn der vierten Klasse erfasst. Bei Kindern mit einer Lernschwäche zeigten sich mehr Verhaltensprobleme als in der KG. In der Art der Verhaltensprobleme konnten keine Unterschiede zwischen den Gruppen LRS und RS gefunden werden. Es ergaben sich Hinweise auf vermehrte Verhaltensprobleme bei erhöhter Intensität der Lernschwäche durch die Kombination an Defiziten sowie eine überdauernde Beeinträchtigung. Die Ergebnisse verdeutlichen, dass eine Berücksichtigung kombinierter Lerndefizite sowie eine umfassende Diagnostik, die Verhaltensprobleme mit einschließt, bereits im Grundschulalter von Bedeutung sind.
Das Frankfurter Frühinterventionsprogramm (FFIP) für Vorschulkinder mit Autismus-Spektrum-Störungen (ASS)
Authors: Kitzerow Janina , Wilker Christian , Teufel Karoline , Soll Sophie , Schneider Monika , Westerwald Eva , Sachse Michael , Marinović Vesna , Berndt Kerstin , Valerian Jennifer , Feineis-Matthews Sabine , Freitag Christine M. 
Published: December 2013

Autismus-Spektrum-Störungen (ASS) sind heterogene und persistierende Entwicklungsstörungen, für die in den letzten Jahrzehnten verschiedene Therapieansätze insbesondere zur frühen Förderung entwickelt wurden. Ziel dieser Studie war es, die Therapieeffekte des Frankfurter Frühinterventionsprogramms (FFIP), einem verhaltenstherapeutischen Ansatz basierend auf dem natürlichen Lernformat, in dem ambulante Einzel- und Gruppentherapie (2 Std./Wo.) mit intensiver Elternarbeit kombiniert werden, zu untersuchen. Nach dem ersten Therapiejahr zeigten sich eine signifikant beschleunigte Steigerung des Entwicklungsalters und eine Verbesserung der rezeptiven und expressiven Sprache. Ein niedrigeres chronologisches Alter und ein höheres Entwicklungsalter zu Therapiebeginn erwiesen sich als positive Einflussfaktoren auf den Zuwachs der expressiven Sprachfertigkeiten. Die Ergebnisse werden im Kontext anderer Frühförderprogramme diskutiert.
PKPD Modeling of Predictors for Adverse Effects and Overall Survival in Sunitinib‐Treated Patients With GIST
Authors: Hansson EK , Ma G , Amantea MA , French J , Milligan PA , Friberg LE , Karlsson MO 
Published: December 2013

A modeling framework relating exposure, biomarkers (vascular endothelial growth factor (VEGF), soluble vascular endothelial growth factor receptor (sVEGFR)‐2, ‐3, soluble stem cell factor receptor (sKIT)), and tumor growth to overall survival (OS) was extended to include adverse effects (myelosuppression, hypertension, fatigue, and hand–foot syndrome (HFS)). Longitudinal pharmacokinetic–pharmacodynamic models of sunitinib were developed based on data from 303 patients with gastrointestinal stromal tumor. Myelosuppression was characterized by a semiphysiological model and hypertension with an indirect response model. Proportional odds models with a first‐order Markov model described the incidence and severity of fatigue and HFS. Relative change in sVEGFR‐3 was the most effective predictor of the occurrence and severity of myelosuppression, fatigue, and HFS. Hypertension was correlated best with sunitinib exposure. Baseline tumor size, time courses of neutropenia, and relative increase of diastolic blood pressure were identified as predictors of OS. The framework has potential to be used for early monitoring of adverse effects and clinical response, thereby facilitating dose individualization to maximize OS.CPT Pharmacometrics Syst. Pharmacol. (2013) 2, e85; doi:10.1038/psp.2013.62; published online 4 December 2013
The relevance and applicability of oocyst prevalence as a read-out for mosquito feeding assays
Authors: Stone Will J. R. , Eldering Maarten , van Gemert Geert-Jan , Lanke Kjerstin H. W. , Grignard Lynn , van de Vegte-Bolmer Marga G. , Siebelink-Stoter Rianne , Graumans Wouter , Roeffen Will F. G. , Drakeley Chris J. , Sauerwein Robert W. , Bousema Teun 
Published: December 2013

AbstractMosquito feeding assays are important in evaluations of malaria transmission-reducing interventions. The proportion of mosquitoes with midgut oocysts is commonly used as an outcome measure, but in natural low intensity infections the effect of oocyst non-rupture on mosquito infectivity is unclear. By identifying ruptured as well as intact oocysts, we show that in low intensity P. falciparum infections i) 66.7–96.7% of infected mosquitoes experienced oocyst rupture between 11–21 days post-infection, ii) oocyst rupture led invariably to sporozoite release, iii) oocyst rupture led to salivary gland infections in 97.8% of mosquitoes and iv) 1250 (IQR 313-2400) salivary gland sporozoites were found per ruptured oocyst. These data show that infectivity can be predicted with reasonable certainty from oocyst prevalence in low intensity infections. High throughput methods for detecting infection in whole mosquitoes showed that 18s PCR but not circumsporozoite ELISA gave a reliable approximation of mosquito infection rates on day 7 post-infection.
15–40 GHz wideband CMOS mixer
Authors: Cao Jia , Li Zhiqun , Li Qin , Wang Zhigong 
Published: December 2013

A wideband double‐balanced mixer using 90 nm CMOS technology is demonstrated. The DC current paths of the transconductance stage and the switch stage are separated individually by an integrated transformer balun. The primary coil is absorbed in the DC path of transconductance and functions as an inductive load. Simultaneously, the secondary coils perform as a current source of the switch stage. The transconductance employs a common gate amplifier together with the gate‐inductive gain‐peaking technique for providing a wideband input matching and extending the operating bandwidth. The fabricated mixer operates from 15 to 40 GHz with around 5 dB conversion gain, matches to 50 Ω over the full band and only takes up 0.39 mm2.
6‐kV, 130‐ps rise‐time pulsed‐power circuit featuring cascaded compression by fast recovery and avalanche diodes
Authors: Kesar A. S. , Merensky L. M. , Ogranovich M. , Kardo‐Sysoev A. F. , Shmilovitz D. 
Published: December 2013

Drift‐step‐recovery diodes (DSRDs) are used as ∼ 1 ns high‐voltage opening switches by pumping them slowly in the forward direction and then pulsing them quickly in the reverse direction. The fast opening occurs when the reverse current discharges the carriers that were stored in the DSRD junction during the forward cycle. Typical forward and reverse timescales are tens and a few nanoseconds, respectively. Although a state‐of‐the‐art metal‐oxide semiconductor field effect transistor may pulse the DSRD at a rise‐rate of about 20 A/ns, the DSRD itself can be used to pulse another DSRD at a rise‐rate of about 60 A/ns. An enhanced performance by the proposed method, resulting in a high‐voltage nanosecond pulse has been reported. This pulse was then further sharpened by driving a fast avalanche diode. A 6‐kV, 130‐ps rise‐time, with a rise‐rate exceeding 40 kV/ns circuit is presented.
High output power, fibre‐coupled distributed feedback lasers operating near 2.05 μm wavelength range
Authors: Bagheri M. , Frez C. , Kelly B. , Gupta J.A. , Forouhar S. 
Published: December 2013

Single‐mode operation of fibre‐pigtailed distributed feedback semiconductor lasers in the 2.05 μm range has been demonstrated. The lasers are packaged inside standard butterfly modules with output powers in excess of 10 mW at the end of polarisation maintaining optical fibre. The fibre‐pigtailed lasers show excellent sidemode suppression ratios (> 50 dB) and have a mode‐hop free tunability larger than 1 nm. The output of the optical fibre has linear polarisation with better than 20 dB extinction over the operating current and temperatures.
Compact UWB BPF using coupled‐line triple‐mode resonator
Authors: Chen Hui 
Published: December 2013

A novel and compact microstrip ultra‐wideband (UWB) bandpass filter (BPF) based on a triple‐mode resonator is designed, fabricated and measured. The proposed resonator is composed of a coupled line with a half‐pass characteristic, which is connected directly with each other at one end and is short‐circuited to the grounding plane at the other end. A simple structure and design approach to the proposed filter is provided and demonstrated. To implement the design on a microstrip, the directly tapped‐transition input/output ports are used to excite the coupled‐line multi‐mode resonator. The measured results are in good agreement with the electromagnetic simulated results. The proposed filter shows a 3 dB fractional bandwidth of 117.3% at the central frequency (fc) with a return loss of better than 12 dB and an insertion loss of < 0.5 dB within the passband response.
75 nm T‐shaped gate for In0.17Al0.83N/GaN HEMTs with minimal short‐channel effect
Authors: Geum D.M. , Shin S.H. , Kim M.S. , Jang J.H. 
Published: December 2013

Lattice‐matched InAlN/gallium nitride high electron‐mobility transistors with a 6 nm‐thick InAlN barrier layer were fabricated and characterised. By introducing a very thin InAlN Schottky layer, the short‐channel effect could be minimised. The devices with a gate length of 75 nm exhibited output resistance as high as 56.9 Ω mm together with a drain‐induced barrier lowering as low as 63 mV/V. The devices also demonstrated excellent high‐frequency characteristics such as a unity current gain cutoff frequency (fT) of 170 GHz and a maximum oscillation frequency (fmax) of 210 GHz.
Flexible meandered loop antenna for implants in MedRadio and ISM bands
Authors: Alrawashdeh R. , Huang Y. , Cao P. 
Published: December 2013

A flexible meandered loop antenna is proposed, designed and realised for small cylindrical implantable devices. This antenna covers the Medical Device Radiocommunications Service (MedRadio) and the 433–434 MHz industrial, scientific and medical (ISM) bands, and is probably the smallest reported flexible implantable antenna that covers these bands. This antenna has shown a robust performance in the presence of implant internal components and has a realised gain of − 28.4 dBi inside a model of a human upper arm.
Tunable bandpass filter with low‐loss and enhanced selectivity based on controllable coupled negative resistance
Authors: Chen Jun , Zhu Xiao‐Wei , Ge Chuan , Cao Li‐Na 
Published: December 2013

A tunable bandpass filter (BPF) with low‐loss and enhanced selectivity based on controllable coupled negative resistance is presented. Owing to the use of the coupled negative resistance, the insertion loss and the selectivity are improved significantly from 800 to 1000 MHz. Furthermore, a novel method of introducing an open‐circuited stub and a short‐circuited stub to control the negative resistance effect is proposed, which makes the adjustment of the negative resistance much more flexible. The measured active BPF shows a bandwidth of 56 MHz, an insertion loss of − 0.44 dB, a noise figure of 2.6 dB, 1 dB compression point of 0 dBm and third‐order intercept point of 8.8 dBm at 900 MHz.
Ultra‐wideband SAW sensors and tags
Authors: Lamothe M. , Plessky V. , Friedt J.‐M. , Ostertag T. , Ballandras S. 
Published: December 2013

A sensor system using ultra‐wideband frequency technology and passive surface acoustic wave (SAW) sensors/tags has been demonstrated experimentally. The system operates with a frequency bandwidth of 500 MHz, which results in compressed RF pulses of about 2 ns duration, including just a few sinusoids with amplitude modulation. A correlation method is developed to measure the delay between two echoes with high resolution, avoiding the phase ambiguity problem. For temperature, deformation or other measurand a simple structure including only two reflectors is sufficient. This method is used in a system which simultaneously remotely measures a few temperature sensors with a resolution of 0.1°C. The operation of the system in a strongly reflecting environment (inside a metal box) is demonstrated.
Views of pregnant women in South Western Sydney towards dental care and an oral‐health program initiated by midwives
Authors: George Ajesh , Johnson Maree , Blinkhorn Anthony , Ajwani Shilpi , Ellis Sharon , Bhole Sameer 
Published: December 2013

Issues addressedOral health during pregnancy is important, yet is often neglected by women. A program is currently being developed for midwives in Australia to promote maternal oral health. The aim of this study was to record the views of pregnant women in Australia towards dental care and midwives promoting oral health.MethodsUsing convenience sampling, a cross‐sectional survey was undertaken of 241 pregnant women attending a metropolitan hospital in South Western Sydney in 2010.ResultsOnly 10% of women received oral‐health promotional material during pregnancy. More than 50% reported dental problems, yet only 17% had discussed this with their midwives and less than half (44.6%) had sought dental treatment. The main barriers to obtaining dental care were: lack of awareness, safety concerns about dental treatment and dental costs. Pregnant women were more likely (P < 0.05) to see a dentist if they had received information about oral health (odds ratio (OR) 3.25, 95% CI 1.34–7.90) and had private health insurance (OR 2.47, 95% CI 1.26–4.85). Most women (> 90%) were receptive to midwives providing oral‐health education, assessments and referrals to affordable dental services.ConclusionThis study has shown that pregnant women are receiving limited dental advice and are concerned about dental costs. It has also confirmed for the first time in Australia that women are very positive about receiving oral‐health advice from midwives during their pregnancy.So what?Oral‐health promotion programs during pregnancy should consider using midwives to increase dental awareness among women and provide pathways to affordable dental services.
Automated annotation of developmental stages ofDrosophilaembryos in images containing spatial patterns of expression
Authors: Yuan Lei , Pan Cheng , Ji Shuiwang , McCutchan Michael , Zhou Zhi-Hua , Newfeld Stuart J. , Kumar Sudhir , Ye Jieping 
Published: December 2013

AbstractMotivation: Drosophila melanogaster is a major model organism for investigating the function and interconnection of animal genes in the earliest stages of embryogenesis. Today, images capturing Drosophila gene expression patterns are being produced at a higher throughput than ever before. The analysis of spatial patterns of gene expression is most biologically meaningful when images from a similar time point during development are compared. Thus, the critical first step is to determine the developmental stage of an embryo. This information is also needed to observe and analyze expression changes over developmental time. Currently, developmental stages (time) of embryos in images capturing spatial expression pattern are annotated manually, which is time- and labor-intensive. Embryos are often designated into stage ranges, making the information on developmental time course. This makes downstream analyses inefficient and biological interpretations of similarities and differences in spatial expression patterns challenging, particularly when using automated tools for analyzing expression patterns of large number of images.Results: Here, we present a new computational approach to annotate developmental stage for Drosophila embryos in the gene expression images. In an analysis of 3724 images, the new approach shows high accuracy in predicting the developmental stage correctly (79%). In addition, it provides a stage score that enables one to more finely annotate each embryo so that they are divided into early and late periods of development within standard stage demarcations. Stage scores for all images containing expression patterns of the same gene enable a direct way to view expression changes over developmental time for any gene. We show that the genomewide-expression-maps generated using images from embryos in refined stages illuminate global gene activities and changes much better, and more refined stage annotations improve our ability to better interpret results when expression pattern matches are discovered between genes.Availability and implementation: The software package is available for download at: http://www.public.asu.edu/∼jye02/Software/Fly-Project/.Contact: jieping.ye@asu.eduSupplementary information: Supplementary data are available at Bioinformatics online.
On the origin of variable structures in the winds of hot luminous stars
Authors: Michaux Yannick J. L. , Moffat Anthony F. J. , Chené André-Nicolas , St-Louis Nicole 
Published: December 2013

Abstract
Examination of the temporal variability properties of several strong optical recombination lines in a large sample of Galactic Wolf–Rayet (WR) stars reveals possible trends, especially in the more homogeneous WC than the diverse WN subtypes, of increasing wind variability with cooler subtypes. This could imply that a serious contender for the driver of the variations is stochastic, magnetic subsurface convection associated with the 170 kK partial-ionization zone of iron, which should occupy a deeper and larger zone of greater mass in cooler WR subtypes. This empirical evidence suggests that the heretofore proposed ubiquitous driver of wind variability, radiative instabilities, may not be the only mechanism playing a role in the stochastic multiple small-scaled structures seen in the winds of hot luminous stars. In addition to small-scale stochastic behaviour, subsurface convection guided by a global magnetic field with localized emerging loops may also be at the origin of the large-scale corotating interaction regions as seen frequently in O stars and occasionally in the winds of their descendant WR stars.
The complex methylome of the human gastric pathogen Helicobacter pylori
Authors: Krebes Juliane , Morgan Richard D. , Bunk Boyke , Spröer Cathrin , Luong Khai , Parusel Raphael , Anton Brian P. , König Christoph , Josenhans Christine , Overmann Jörg , Roberts Richard J. , Korlach Jonas , Suerbaum Sebastian 
Published: December 2013

Abstract
The genome of Helicobacter pylori is remarkable for its large number of restriction-modification (R-M) systems, and strain-specific diversity in R-M systems has been suggested to limit natural transformation, the major driving force of genetic diversification in H. pylori. We have determined the comprehensive methylomes of two H. pylori strains at single base resolution, using Single Molecule Real-Time (SMRT®) sequencing. For strains 26695 and J99-R3, 17 and 22 methylated sequence motifs were identified, respectively. For most motifs, almost all sites occurring in the genome were detected as methylated. Twelve novel methylation patterns corresponding to nine recognition sequences were detected (26695, 3; J99-R3, 6). Functional inactivation, correction of frameshifts as well as cloning and expression of candidate methyltransferases (MTases) permitted not only the functional characterization of multiple, yet undescribed, MTases, but also revealed novel features of both Type I and Type II R-M systems, including frameshift-mediated changes of sequence specificity and the interaction of one MTase with two alternative specificity subunits resulting in different methylation patterns. The methylomes of these well-characterized H. pylori strains will provide a valuable resource for future studies investigating the role of H. pylori R-M systems in limiting transformation as well as in gene regulation and host interaction.
High Genetic Diversity and Adaptive Potential of Two Simian Hemorrhagic Fever Viruses in a Wild Primate Population
Authors: Bailey Adam L. , Lauck Michael , Weiler Andrea , Sibley Samuel D. , Dinis Jorge M. , Bergman Zachary , Nelson Chase W. , Correll Michael , Gleicher Michael , Hyeroba David , Tumukunde Alex , Weny Geoffrey , Chapman Colin , Kuhn Jens H. , Hughes Austin L. , Friedrich Thomas C. , Goldberg Tony L. , O’Connor David H. 
Published: December 2013

ABSTRACTKey biological properties such as high genetic diversity and high evolutionary rate enhance the potential of certain RNA viruses to adapt and emerge. Identifying viruses with these properties in their natural hosts could dramatically improve disease forecasting and surveillance. Recently, we discovered two novel members of the viral familyArteriviridae: simian hemorrhagic fever virus (SHFV)-krc1 and SHFV-krc2, infecting a single wild red colobus (Procolobus rufomitratus tephrosceles) in Kibale National Park, Uganda. Nearly nothing is known about the biological properties of SHFVs in nature, although the SHFV type strain, SHFV-LVR, has caused devastating outbreaks of viral hemorrhagic fever in captive macaques. Here we detected SHFV-krc1 and SHFV-krc2 in 40% and 47% of 60 wild red colobus tested, respectively. We found viral loads in excess of 106− 107RNA copies per milliliter of blood plasma for each of these viruses. SHFV-krc1 and SHFV-krc2 also showed high genetic diversity at both the inter- and intra-host levels. Analyses of synonymous and non-synonymous nucleotide diversity across viral genomes revealed patterns suggestive of positive selection in SHFV open reading frames (ORF) 5 (SHFV-krc2 only) and 7 (SHFV-krc1 and SHFV-krc2). Thus, these viruses share several important properties with some of the most rapidly evolving, emergent RNA viruses.