bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Reappraisal of Albert Aftalion’s Theory of Structural Transformation in an Era of Decarbonization
Authors: Coffman D'Maris , Scazzieri Roberto 
Published: August 2024

AbstractDecarbonization is a momentous challenge for capitalism and makes one ask which changes in its morphology may be necessary to achieve that objective. The contribution by the French economist Albert Aftalion (1874–1956), with its emphasis on intermediate levels of aggregation (the “meso“ approach), the differentiated time profiles of economic actoivities, and their differential speeds of reaction to dynamic impulses, provides an invaluable heuristic for conceptualizing the structural transformations required by transition to a low energy regime. Aftalion’s analysis of industrial capitalism emphasizes that structural changes occur along multiple co-existing time horizons. This provides tools to analyze the time constraints on the sequencing of structural changes for different sectors on a decarbonization trajectory without neglecting the strict time requirements for implementing effective climate change mitigation. This interplay of time horizons is central to decarbonization, and it will require a new balance between the invisible hand of markets and the visible hand of states and other public bodies. Moreover, Aftalion’s emphasis on material constraints offers a novel approach to conceptualizing the importance of intermediate levels of aggregation in economic theory, thereby offering a new basis for sectoral policymaking and a fundamental challenge to institutionalist accounts of the morphology of capitalism.
The Bend on the Haiyuan Strike‐Slip Fault Leads to Segmented Activity of the Minle‐Damaying Thrust Fault in the Qilian Shan, the Northeastern Tibetan Plateau
Authors: Liu Qingri , Xiong Jianguo , Zhang Peizhen , Tao Wei , Huang Luyuan , Yang Xuhang , Zhang Yihui , Huang Feipeng , Zhang Xiuli , Zhang Huiping , Li Chuanyou , Li Youli 
Published: August 2024

AbstractThe present tectonic regime of the Qilian Shan is dominated by large northeast and northwest striking strike‐slip faults and northwest striking thrust faults. Deformation distribution between the subparallel Haiyuan Strike‐slip Fault and the Minle‐Damaying Thrust Fault (MDF) is crucial for understanding the orogenic mechanism of the northeastern Tibetan Plateau. However, the uncertain kinematics of the MDF and the stress variation along the strike‐varying Haiyuan Fault inhibit further discussion of their relationship. Five key sites along the MDF were selected for analysis of terrace abandonment ages and vertical offsets to determine the slip rates. Two finite element models were constructed to calculate the stress‐strain relationship between the Haiyuan Fault and MDF. We find that the activity of the MDF can be divided into two segments by a stepover with less activity and lower terrain at the Xida River site. Shortening rates of the MDF vary between 0.2 and 2.4 mm/a since the late Pleistocene with trapezoidal trends on both fault segments. The two finite element models and GPS data reveal that the strain rates are lower at the Xida River site but higher at the Menyuan Bend on the Haiyuan Fault. We infer that long‐term strain accumulation at the Menyuan Bend may have mitigated the tectonic activity northeast to the bend under the northeastward stress field, including the activity of the MDF at the Xida River site, and resulted in the segmentation of the MDF.
Aerosol‐Calibrated Matched Filter Method for Retrievals of Methane Point Source Emissions Over the Los Angeles Basin
Authors: Feng Chenxi , Chen Sihe , Zeng Zhao‐Cheng , Luo Yangcheng , Natraj Vijay , Yung Yuk L. 
Published: August 2024

AbstractMethane, with a global warming potential roughly 86 times greater than carbon dioxide over a 20‐year timeframe, plays a crucial role in global warming. Remote sensing retrieval is a pivotal methodology for identifying methane emission sources, with accuracy influenced largely by surface and atmospheric properties, including aerosols. In this study, we propose an Aerosol‐Calibrated Matched Filter (ACMF) algorithm to improve the traditional Matched Filter (MF) method. Our new approach incorporates an aerosol scattering correction factor to reduce the aerosol‐induced bias on methane retrievals. Validating our algorithm through simulated spectra, we demonstrate that considering the aerosol scattering effect significantly reduces retrieval errors compared to MF methods by an average of approximately 90%. We apply our newly developed algorithm to hyperspectral data obtained from the Airborne Visible/Infrared Imaging Spectrometer—Next Generation in the Los Angeles Basin and focus on 11 plumes identified through case studies. Our results reveal that ACMF estimates of emission rates and inversion uncertainties exhibit an average reduction of approximately 4% compared to corresponding MF results, with deviation increasing with aerosol optical depth (AOD).
Unveiling the Transition From Paleolake Lisan to Dead Sea Through the Analysis of Lake Paleoshorelines and Radiometric Dating of Fossil Stromatolites
Authors: Jara‐Muñoz Julius , Agnon Amotz , Fohlmeister Jens , Tomás Sara , Mey Jürgen , Frank Norbert , Schröder Birgit , Schröder‐Ritzrau Andrea , Garcin Yannick , Darvasi Yaniv , Melnick Daniel , Mutti Maria , Strecker Manfred R. 
Published: August 2024

AbstractTo date, the most complete paleolake‐level reconstructions for the late Pleistocene water bodies that once occupied the Dead Sea depression have been based on the combination of dating of lake sediments and terrestrial materials. However, despite these major accomplishments, there is still limited spatial control regarding the water levels, suggesting some degree of uncertainty concerning the magnitude and rate of lake‐level changes. Here, we re‐examine the late Pleistocene lake‐level changes in the Dead Sea during the transition from paleolake Lisan to the present‐day Dead Sea. We rely on systematic dating of fossil stromatolites including 84 radiocarbon and 15 U‐series ages, stable‐isotope measurements, paleobiology, high‐resolution topography, and numerical modeling to assess lake‐level changes. Our results indicate that the highstand of paleolake Lisan was of shorter duration and the transition between Lake Lisan and the Dead Sea occurred at least 5 Kyrs earlier than previously indicated. By refining the timeline and accuracy of lake‐level positions during the transition paleolake Lisan—Dead Sea, our study offers new insights into the regional and local paleo‐climatic conditions during the last glacial period in this region.
Unloading Uplift Caused by Surface Processes in New Zealand's Southern Alps
Authors: Liu Shaozhuo , Moulin Adrien , Jónsson Sigurjón 
Published: August 2024

AbstractThe Southern Alps experiences rapid bedrock uplift and intense surface processes like erosion and deglaciation. We quantify how the erosion and deglaciation contribute to the ongoing vertical motions using geophysical models. The erosional unloading uplift is found to be 0.5–1.5 mm/yr throughout the central Southern Alps, whereas the recent deglaciation may locally produce uplift up to 1–3 mm/yr. The estimated unloading uplift accounts for 10%–40% of the GNSS‐observed uplift. After correcting the unloading uplift, the GNSS‐observed uplift can be explained by about 4–6 mm/yr dip‐slip motion on the Alpine fault, which is 10%–50% below previous geodetic estimates. Hence, unloading uplift must be evaluated when interpreting geodetic observations in tectonically active mountain ranges subjected to intense surface processes.
Basaltic Pulses and Lithospheric Thinning—Plio‐Pleistocene Magmatism and Rifting in the Turkana Depression (East African Rift System)
Authors: Cancel Vazquez Sahira M. , Rooney Tyrone O. , Brown Eric L. , Bollinger Andrew , Bastow Ian D. , Steiner R. Alex , Kappelman John 
Published: August 2024

AbstractThe East African Rift System (EARS) provides an opportunity to constrain the relationship between magmatism and plate thinning. During continental rifting, magmatism is often considered a derivative of strain accommodation—as the continental plate thins, decompression melting of the upper mantle occurs. The Turkana Depression preserves among the most extensive Cenozoic magmatic record in the rift. This magmatic record, which comprises distinct basaltic pulses followed by periods of relative magmatic quiescence, is perplexing given the lack of evidence for temporal heterogeneity in the thermo‐chemical state of the upper mantle, the nonexistence of lithospheric delamination related fast‐wave speed anomalies in the upper mantle, and the absence of evidence for sudden, accelerated divergence of Nubia and Somalia. We focus on the Pliocene Gombe Stratoid Series and show how lithospheric thinning may result in pulsed magma generation from a plume‐influenced mantle. By solving the 1D advection‐diffusion equation using rates of plate thinning broadly equivalent to those measured geodetically today we show that despite elevated mantle potential temperature, melt generation may not occur and thereby result in extended intervals of quiescence. By contrast, an increase in the rate of plate thinning can generate magma volumes that are on the order of that estimated for the parental magma of the Gombe Stratoid Series. The coincidence of large‐volume stratiform basalt events within the East African Rift shortly before the development of axial zones of tectonic‐magmatic activity suggests that the plate thinning needed to form these stratiform basalts may herald the onset of the localization of strain.
Targeting Lactobacillus johnsonii to reverse chronic kidney disease
Authors: Miao Hua , Liu Fei , Wang Yan-Ni , Yu Xiao-Yong , Zhuang Shougang , Guo Yan , Vaziri Nosratola D. , Ma Shi-Xing , Su Wei , Shang You-Quan , Gao Ming , Zhang Jin-Hua , Zhang Li , Zhao Ying-Yong , Cao Gang 
Published: August 2024

AbstractAccumulated evidence suggested that gut microbial dysbiosis interplayed with progressive chronic kidney disease (CKD). However, no available therapy is effective in suppressing progressive CKD. Here, using microbiomics in 480 participants including healthy controls and patients with stage 1–5 CKD, we identified an elongation taxonomic chain Bacilli-Lactobacillales-Lactobacillaceae-Lactobacillus-Lactobacillus johnsonii correlated with patients with CKD progression, whose abundance strongly correlated with clinical kidney markers. L. johnsonii abundance reduced with progressive CKD in rats with adenine-induced CKD. L. johnsonii supplementation ameliorated kidney lesion. Serum indole-3-aldehyde (IAld), whose level strongly negatively correlated with creatinine level in CKD rats, decreased in serum of rats induced using unilateral ureteral obstruction (UUO) and 5/6 nephrectomy (NX) as well as late CKD patients. Treatment with IAld dampened kidney lesion through suppressing aryl hydrocarbon receptor (AHR) signal in rats with CKD or UUO, and in cultured 1-hydroxypyrene-induced HK-2 cells. Renoprotective effect of IAld was partially diminished in AHR deficiency mice and HK-2 cells. Our further data showed that treatment with L. johnsonii attenuated kidney lesion by suppressing AHR signal via increasing serum IAld level. Taken together, targeting L. johnsonii might reverse patients with CKD. This study provides a deeper understanding of how microbial-produced tryptophan metabolism affects host disease and discovers potential pathways for prophylactic and therapeutic treatments for CKD patients.
The structure and catalytic mechanism of a pseudoknot-containing hammerhead ribozyme
Authors: Zhan Xuelin , Wilson Timothy J. , Li Zhenzhen , Zhang Jingjing , Yang Yili , Lilley David M. J. , Liu Yijin 
Published: August 2024

AbstractWe have determined the crystal structure of a pseudoknot (PK)-containing hammerhead ribozyme that closely resembles the pistol ribozyme, with essentially identical secondary structure and connectivity. The activity is more sensitive to deletion of the G8 2’OH than to the absence of magnesium ions, indicating that the catalytic mechanism is the same as the extended hammerhead, and distinct from the pistol ribozyme. Here we show that nucleophilic attack is almost perfectly in-line, and the G8 2’OH is well positioned to act as general acid, being directed towards the O5’ leaving group, and 2.9 Å away from it. Despite the similarity in overall structure to the pistol ribozyme, the local structure close to the cleavage site differs, and the PK hammerhead retains its unique mechanistic identity and demonstrates enhanced activity over other hammerhead ribozymes under standard conditions.
p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells
Authors: Majewska Julia , Agrawal Amit , Mayo Avi , Roitman Lior , Chatterjee Rishita , Sekeresova Kralova Jarmila , Landsberger Tomer , Katzenelenbogen Yonatan , Meir-Salame Tomer , Hagai Efrat , Sopher Ilanit , Perez-Correa Juan-Felipe , Wagner Wolfgang , Maimon Avi , Amit Ido , Alon Uri , Krizhanovsky Valery 
Published: August 2024

AbstractThe accumulation of senescent cells promotes ageing and age-related diseases, but molecular mechanisms that senescent cells use to evade immune clearance and accumulate in tissues remain to be elucidated. Here we report that p16-positive senescent cells upregulate the immune checkpoint protein programmed death-ligand 1 (PD-L1) to accumulate in ageing and chronic inflammation. We show that p16-mediated inhibition of cell cycle kinases CDK4/6 induces PD-L1 stability in senescent cells via downregulation of its ubiquitin-dependent degradation. p16-expressing senescent alveolar macrophages elevate PD-L1 to promote an immunosuppressive environment that can contribute to an increased burden of senescent cells. Treatment with activating anti-PD-L1 antibodies engaging Fcγ receptors on effector cells leads to the elimination of PD-L1 and p16-positive cells. Our study uncovers a molecular mechanism of p16-dependent regulation of PD-L1 protein stability in senescent cells and reveals the potential of targeting PD-L1 to improve immunosurveillance of senescent cells and ameliorate senescence-associated inflammation.
An activity-regulated transcriptional program directly drives synaptogenesis
Authors: Yee Callista , Xiao Yutong , Chen Hongwen , Reddy Anay R. , Xu Bing , Medwig-Kinney Taylor N. , Zhang Wan , Boyle Alan P. , Herbst Wendy A. , Xiang Yang Kevin , Matus David Q. , Shen Kang 
Published: August 2024

AbstractAlthough the molecular composition and architecture of synapses have been widely explored, much less is known about what genetic programs directly activate synaptic gene expression and how they are modulated. Here, using Caenorhabditis elegans dopaminergic neurons, we reveal that EGL-43/MECOM and FOS-1/FOS control an activity-dependent synaptogenesis program. Loss of either factor severely reduces presynaptic protein expression. Both factors bind directly to promoters of synaptic genes and act together with CUT homeobox transcription factors to activate transcription. egl-43 and fos-1 mutually promote each other’s expression, and increasing the binding affinity of FOS-1 to the egl-43 locus results in increased presynaptic protein expression and synaptic function. EGL-43 regulates the expression of multiple transcription factors, including activity-regulated factors and developmental factors that define multiple aspects of dopaminergic identity. Together, we describe a robust genetic program underlying activity-regulated synapse formation during development.
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer’s disease model mice
Authors: Sasmita Andrew Octavian , Depp Constanze , Nazarenko Taisiia , Sun Ting , Siems Sophie B. , Ong Erinne Cherisse , Nkeh Yakum B. , Böhler Carolin , Yu Xuan , Bues Bastian , Evangelista Lisa , Mao Shuying , Morgado Barbara , Wu Zoe , Ruhwedel Torben , Subramanian Swati , Börensen Friederike , Overhoff Katharina , Spieth Lena , Berghoff Stefan A. , Sadleir Katherine Rose , Vassar Robert , Eggert Simone , Goebbels Sandra , Saito Takashi , Saido Takaomi , Saher Gesine , Möbius Wiebke , Castelo-Branco Gonçalo , Klafki Hans-Wolfgang , Wirths Oliver , Wiltfang Jens , Jäkel Sarah , Yan Riqiang , Nave Klaus-Armin 
Published: August 2024

AbstractAmyloid-β (Aβ) is thought to be neuronally derived in Alzheimer’s disease (AD). However, transcripts of amyloid precursor protein (APP) and amyloidogenic enzymes are equally abundant in oligodendrocytes (OLs). By cell-type-specific deletion of Bace1 in a humanized knock-in AD model, APPNLGF, we demonstrate that OLs and neurons contribute to Aβ plaque burden. For rapid plaque seeding, excitatory projection neurons must provide a threshold level of Aβ. Ultimately, our findings are relevant for AD prevention and therapeutic strategies.
Newly synthesized chitosan nanoparticles loaded with caffeine/moringa leaf extracts Halt Her2, BRCA1, and BRCA2 expressions
Authors: Mohammed Hanaa , Karhib Mustafa M. , Al-Fahad Karrar Sabah Jaafar , Atef Atef Mohamed , Eskandrani Areej , Darwish Amira Abd-elfattah , Sary Ahmed Abdallah , Elwakil Bassma H. , Bakr Basant A. , Eldrieny Ahmed M. 
Published: August 2024

AbstractBreast cancer is among the highest morbidity and mortality rates in women around the world. In the present investigation we aimed to synthesis novel nanosystem combining two naturally important anticancer agents with different mechanism of action namely Moringa oleifera and caffeine. Firstly, chemical analysis of Moringa oleifera extract and caffeine was done by gas chromatography-mass spectroscopy (GC–MS) in order to assess the main chemical compounds present and correlate between them and the possible anticancer effect. The novel nanosystem was characterized through dynamic light scattering techniques which revealed the stability and homogeneity of the prepared M. oleifera leaves extract/Caffeine loaded chitosan nanoparticles, while FTIR and transmission electron microscope (TEM) proved the shape and the successful incorporation of M. oleifera leaves extract/Caffeine onto the nanochitosan carrier. Our initial step was to assess the anticancer effect in vitro in cancer cell line MCF-7 which proved the significant enhanced effect of M. oleifera leaves extract/Caffeine nanosystem compared to M. oleifera leaves extract or caffeine loaded nanoparticles. Further studies were conducted in vivo namely tumor biomarkers, tumor volume, bioluminescence imaging, molecular and histopathological investigations. The present study proved the potent anticancer effect of the synthesized M. oleifera leaves extract/Caffeine loaded chitosan nanoparticles. Mo/Caf/CsNPs exhibited a large number of apoptotic cells within the tumor mass while the adipose tissue regeneration was higher compared to the positive control. The prepared nanoparticles downregulated the expression of Her2, BRCA1 and BRCA2 while mTOR expression was upregulated. The aforementioned data demonstrated the successful synergistic impact of Moringa and caffeine in decreasing the carcinoma grade.
Comparison of the therapeutic effect of platelet-rich plasma and injectable platelet-rich fibrin on testicular torsion/detorsion injury in rats
Authors: Eisa Eslam F. M. , Ezzeldein Shimaa A. M. , Mohammed Haiam A. , Abdallah Asmaa A. , Ghonimi Wael A. M. , Abd El Raouf Mustafa 
Published: August 2024

AbstractTesticular torsion is a common disorder in males and results in blockage of testicular circulation with subsequent damage of testicular germ cells. The current work aimed to compare the therapeutic effect of platelet-rich plasma (PRP) and injectable platelet-rich fibrin (i-PRF) on torsion/detorsion (T/D) injury in rats. Forty mature male Wister rats were arranged into 4 groups; (1) Control, (2) T/D, (3) T/D + PRP, and (4) T/D+ i-PRF. The right testis was twisting 1080° clockwise for 3 h in groups 2, 3 and 4, then 10 μl of PRP or i-PRF was injected intra-testicular 3 h after detorsion in groups 3 and 4, respectively. After 30 days postoperatively, the semen quality and hormonal assay were improved in PRP and i-PRF-treated groups with superiority of i-PRF (P < 0.001). High significance of Catalase, Glutathione Peroxidase (GPx), Superoxide Dismutase, Interleukin-1β (IL-1β), Caspase-3 and Tumor necrosis factor-α (TNF-α) was reported in treated rats with PRP and i-PRF (P < 0.001) with superiority to i-PRF-treated rats (P < 0.001). Testicular histoarchitectures were improved in PRP and i-PRF-treated rats with superiority of i-PRF-treated rats. It was concluded that PRP and i-PRF have regenerative efficacy on testicular damage after induced T/D injury with a superior efficacy of i-PRF.
Computational investigation of stochastic Zika virus optimal control model using Legendre spectral method
Authors: Zhu Junjie , Khan Feroz , Khan Sami Ullah , Sumelka Wojciech , Khan Farman U. , AlQahtani Salman A. 
Published: August 2024

AbstractThis study presents a computational investigation of a stochastic Zika virus along with optimal control model using the Legendre spectral collocation method (LSCM). By accumulation of stochasticity into the model through the proposed stochastic differential equations, we appropriating the random fluctuations essential in the progression and disease transmission. The stability, convergence and accuracy properties of the LSCM are conscientiously analyzed and also demonstrating its strength for solving the complex epidemiological models. Moreover, the study evaluates the various control strategies, such as treatment, prevention and treatment pesticide control, and identifies optimal combinations that the intervention costs and also minimize the proposed infection rates. The basic properties of the given model, such as the reproduction number, were determined with and without the presence of the control strategies. For $$R_0<0$$

R
0

<
0

, the model satisfies the disease-free equilibrium, in this case the disease die out after some time, while for $$R_0>1$$

R
0

>
1

, then endemic equilibrium is satisfied, in this case the disease spread in the population at higher scale. The fundamental findings acknowledge the significant impact of stochastic phonemes on the robustness and effectiveness of control strategies that accelerating the need for cost-effective and multi-faceted approaches. In last the results provide the valuable insights for public health department to enabling more impressive mitigation of Zika virus outbreaks and management in real-world scenarios.