bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between household and family composition and mental health of the elderly: mediating role of lifestyle
Authors: Dang Mingxi , Chen Yaojing , Ji John S. , Zhang Yutong , Chen Chuansheng , Zhang Zhanjun 
Published: July 2024

Abstract
Background
Mental health in the elderly has multiple determinants, and studies indicate household and family composition, economic status, and family support are key factors. However, these are difficult to modify, and better lifestyle for the elderly can be a possible intervention. The current study examined the mediating role of lifestyle in the association between these three types of the household and family composition (living alone, living with a spouse, and living with children) and mental health in older adults.

Methods
We studied 5,407 participants (58.7% female, age 45 + years) from the Beijing Aging Brain Rejuvenation Initiative Project. All participants underwent a battery of examinations to measure degree loneliness, depression, and global cognitive function. We also surveyed personal lifestyles. We used a mediation analysis to determine the relative contribution of each lifestyle factor on mental health outcomes.

Results
Older adults living alone rarely participated in mental and social activities and often had irregular diets; those adults living with children spent most of their time caring for grandchildren and had irregular eating and sleeping schedules; those living with a spouse often engaged in a variety of leisure activities and had the best life habits. Mediation analyses showed that dietary and sleeping irregularity partially mediated the negative effects of living alone on mental health, and were moderated by age and gender.

Conclusions
Living with a spouse was associated with benefits for the mental health of middle-aged and older adults (especially older and female individuals), through modifying better lifestyles than those of individuals with the other two types of the household and family composition.
Revealing the significance of early detection of chronic obstructive pulmonary disease: insights from healthy lung initiative data at COP27 conference
Authors: Amin Wagdy , Ashmawy Rasha , Sharaf Sandy , Zeina Sally , Hammouda Esraa Abdellatif , Mohamed Nancy , Gamal Rewan , Hamr Dina Abu , Gebril Heba , Alaa Ola , Taha Ussama , El-Feel Hazem 
Published: July 2024

Abstract
Background
Climate change poses a significant threat to respiratory health, exacerbating conditions like asthma, Chronic Obstructive Pulmonary Disease (COPD), and respiratory infections increasing morbidity and mortality indirectly through exposure to greenhouse gases. During the 27th Climate Change Conference (COP27), the Healthy Lung Initiative (HLI) for the early detection of COPD among smokers was launched in Egypt.

Objective
We aimed to detect the prevalence and predictors of confirmed COPD among smokers and assess physicians’ adherence to prescribing pulmonary function tests (PFTs) among the COP27 conference attendees.

Methods
This study utilized smokers’ data from the HLI, employing a cross-sectional design with an interview-based questionnaire, supplemented by spirometry for lung function evaluation. Participants, comprising Egyptian and non-Egyptian residents in Sharm El-Sheikh city, were provided with educational materials and encouraged to seek further evaluation from a pulmonologist.

Results
The HLI study, conducted from November 6th to 20th, 2022, involved 1133 participants, 90% (1047) of whom were smokers. Most smokers were males (96.3%) and Egyptians (98.6%), with half aged 30–39 and the majority starting smoking within the last 20 years. Despite common respiratory symptoms, 47% suffered from dyspnea on exertion, and only 4.3% have undergone lung function tests, suggesting a potential underdiagnosis of COPD. Most participants (82.6%) had an FEV1/FVC ratio > 70%, indicating no spirometry-confirmed COPD diagnosis, while 147 participants (17% of them) exhibited all three cardinal COPD symptoms simultaneously. Male gender and daily cigarette consumption were significant predictors for confirmed COPD, while age showed no significance in regression analyses.

Conclusion
The ongoing HLI focuses on early detection and education to combat smoking-related risks, particularly among middle-aged males, while also highlighting the need for comprehensive strategies to address the intersection of smoking and climate change.
Attention-enhanced dilated convolution for Parkinson’s disease detection using transcranial sonography
Authors: Chen Shuang , Shi Yuting , Wan Linlin , Liu Jing , Wan Yongyan , Jiang Hong , Qiu Rong 
Published: July 2024

Abstract
Background
Transcranial sonography (TCS) plays a crucial role in diagnosing Parkinson's disease. However, the intricate nature of TCS pathological features, the lack of consistent diagnostic criteria, and the dependence on physicians' expertise can hinder accurate diagnosis. Current TCS-based diagnostic methods, which rely on machine learning, often involve complex feature engineering and may struggle to capture deep image features. While deep learning offers advantages in image processing, it has not been tailored to address specific TCS and movement disorder considerations. Consequently, there is a scarcity of research on deep learning algorithms for TCS-based PD diagnosis.

Methods
This study introduces a deep learning residual network model, augmented with attention mechanisms and multi-scale feature extraction, termed AMSNet, to assist in accurate diagnosis. Initially, a multi-scale feature extraction module is implemented to robustly handle the irregular morphological features and significant area information present in TCS images. This module effectively mitigates the effects of artifacts and noise. When combined with a convolutional attention module, it enhances the model's ability to learn features of lesion areas. Subsequently, a residual network architecture, integrated with channel attention, is utilized to capture hierarchical and detailed textures within the images, further enhancing the model's feature representation capabilities.

Results
The study compiled TCS images and personal data from 1109 participants. Experiments conducted on this dataset demonstrated that AMSNet achieved remarkable classification accuracy (92.79%), precision (95.42%), and specificity (93.1%). It surpassed the performance of previously employed machine learning algorithms in this domain, as well as current general-purpose deep learning models.

Conclusion
The AMSNet proposed in this study deviates from traditional machine learning approaches that necessitate intricate feature engineering. It is capable of automatically extracting and learning deep pathological features, and has the capacity to comprehend and articulate complex data. This underscores the substantial potential of deep learning methods in the application of TCS images for the diagnosis of movement disorders.

Graphical Abstract
Clinical implications of the family history in patients with lung cancer: a systematic review of the literature and a new cross-sectional/prospective study design (FAHIC: lung)
Authors: Citarella Fabrizio , Takada Kazuki , Cascetta Priscilla , Crucitti Pierfilippo , Petti Roberta , Vincenzi Bruno , Tonini Giuseppe , Venanzi Francesco M. , Bulotta Alessandra , Oresti Sara , Greco Carlo , Ramella Sara , Crinò Lucio , Delmonte Angelo , Ferrara Roberto , Di Maio Massimo , Gurrieri Fiorella , Cortellini Alessio 
Published: July 2024

AbstractCompared to other malignancies, few studies have investigated the role of family history of cancer (FHC) in patients with lung cancer, yielding largely heterogeneous results. We performed a systematic literature review in accordance with PRISMA guidelines, searching the PubMed and Scopus databases from their inception to November 25, 2023, to identify studies reporting on the role of FHC in patients with lung cancer. A total of 53 articles were included, most with a retrospective design and encompassing a variety of geographical areas and ethnicities.Thirty studies (56.6%) assessed patients with non-small cell lung cancer (NSCLC), while 17 studies (32.1%) assessed patients with mixed histologies. Overall, the rates of FHC ranged from 8.3 to 68.9%, and the rates of family history of lung cancer ranged from 2 to 46.8%. Twenty-seven studies investigated FHC as a potential risk factor for lung cancer, with more than half reporting an increased risk for subjects with FHC. Five studies reported on the potential role of FHC in determining clinical outcomes, and twelve studies examined the relationship between FHC and germline mutations. Notably, only one study reported a significantly increased rate of germline mutations, including ATM, BRCA2, and TP53, for patients with a family history of lung cancer compared to those without, but both groups had a low prevalence of mutations (< 1%).The FAHIC—Lung (NCT06196424) is the first cross-sectional/prospective study specifically developed to identify FHC patterns and within-family clusters of other risk factors, including smoking, to guide patients with NSCLC to systematic genetic counseling. Acknowledging the largely heterogeneous results of our systematic review and considering the clinical implications of detecting pathogenic germline variants (PGVs), the FAHIC-lung study aims to identify patients potentially enriched with PGVs/likely PGVs to direct them to germline screening outside of the research setting.
Latent heterogeneity of deviant behaviors and associated factors among ethnic minority adolescents: a latent class analysis
Authors: Cui Kunjie , Fong Ted C. T. , Yip Paul Siu Fai 
Published: July 2024

Abstract
Background
Deviant behaviors are common during adolescence. Despite the diversity of juvenile delinquency, the patterns of deviant behaviors remain unclear in ethnic minorities. The present study aimed to evaluate the latent heterogeneity of deviant behaviors and associated factors in ethnic minority Yi adolescents.

Methods
The present study recruited a large sample of 1931 ethnic minority Yi adolescents (53.4% females, mean age = 14.7 years, SD 1.10) in five secondary schools in 2022 in Sichuan, China. The participants completed measures on 13 deviant behaviors and demographic characteristics, attitudinal self-control, and psychological distress. Sample heterogeneity of deviant behaviors was analyzed via latent class analysis using class as the cluster variable.

Results
The data supported three latent classes with measurement invariance by sex. 68.2%, 28.0%, and 3.8% of the sample were in the Normative, Borderline, and Deviant class, with minimal, occasional, and extensive deviant behaviors, respectively. The Deviant class was more prevalent in males (6.5%) than females (1.6%). There were significant class differences in domestic violence, school belonging, self-control, anxiety, and depressive symptoms. Males, domestic violence, low school belonging, and impaired self-control significantly predicted higher odds of the Deviant and Borderline classes compared to the normative class.

Conclusion
This study provided the first results on three latent classes of deviant behaviors with distinct profiles in ethnic minority adolescents in rural China. These results have practical implications to formulate targeted interventions to improve the psycho-behavioral functioning of the at-risk adolescents in ethnic minorities.
The triglyceride-glucose index is a predictor of major adverse cardiovascular events in patients with coronary artery disease and psoriasis: a retrospective cohort study
Authors: Fu Bingqi , Zeng Yan , Wang Man , Zhao Lin , Sun Lin , Wang Tianjie , Dong Junle , Yang Weixian , Hua Wei 
Published: July 2024

Abstract
Background
The association between the triglyceride-glucose (TyG) index and clinical outcomes in patients with both coronary artery disease (CAD) and psoriasis is unclear. This study investigated the association between the TyG index and major adverse cardiovascular events (MACE) in patients with both CAD and psoriasis.

Methods
This retrospective cohort study included patients diagnosed with both CAD and psoriasis who underwent coronary angiography at the Fuwai Hospital, Beijing, China, between January 2017 and May 2022. The study endpoint was the occurrence of MACE or end of follow-up time. Multivariate Cox proportional analysis and restricted cubic splines (RCS) were used to determine the association between the TyG index and MACE. Receiver operating characteristic (ROC) curves were used to determine the optimal threshold value of the TyG index for predicting MACE.

Results
This study enrolled 293 patients with both CAD and psoriasis, including 258 (88.1%) males with a mean age of 58.89 ± 9.61 years. Patients were divided into four groups based on the TyG quartiles: Q1 (N = 74), Q2 (N = 73), Q3 (N = 73), and Q4 (N = 73). After adjusting for the potential confounders, the TyG index was independently associated with MACE, both as a continuous variable (HR = 1.53, 95% CI = 1.03–2.28, P = 0.035) and as a categorical variable (Q1: reference; Q2: HR = 1.85, 95% CI = 0.88–3.87, P = 0.105; Q3: HR = 2.39, 95% CI = 1.14-5.00, P = 0.021; Q4: HR = 2.19, 95% CI = 1.001–4.81, P = 0.0497; P for trend = 0.039). RCS analysis showed an linear association between the TyG index and MACE (P-overall = 0.027, P-non-linear = 0.589). ROC curve analysis showed that the TyG index of ≥ 8.73 was the optimal threshold value (area under the ROC curve = 0.60, 95% CI 0.53–0.67). TyG index ≥ 8.73 was significantly associated with MACE (HR = 2.10, 95% CI = 1.32–3.34, P = 0.002). After adjustment for confounders, the TyG index showed independent association with MACE (HR = 2.00, 95% CI = 1.17–3.42, P = 0.011).

Conclusions
The TyG index showed a positive linear correlation with MACE in patients with both CAD and psoriasis. The TyG index of ≥ 8.73 might be the optimal threshold for predicting MACE.

Graphical Abstract
Investigation of the long-term variation of gravity waves over South America using empirical orthogonal function analysis
Authors: Ayorinde Toyese Tunde , Wrasse Cristiano Max , Takahashi Hisao , Barros Diego , Figueiredo Cosme Alexandre Oliveira Barros , da silva Ligia Alves , Bilibio Anderson Vestena 
Published: July 2024

AbstractThe spatial and temporal variability of gravity waves (GWs) potential energy (Ep) over South America (SA) was examined by analyzing temperature profiles obtained through the utilization of Sounding of the Atmosphere using Broadband Emission Radiometry (SABER) from January 2002 to December 2021. We used the empirical orthogonal function (EOF) analysis to decompose GWs parameters and to analyze the GW variations over SA. We considered the first three eigenmodes (EOF1, EOF2, and EOF3) and their principal components (PC1, PC2, and PC3) of the EOF decomposition, which accounts for ∼80–90% of the total GWs variation over SA. Further, we analyzed the coupled variation of Ep and zonal mean wind (U) to verify their inter-dependencies using the singular value decomposition (SVD). The spatial variation showed that different localized mechanisms generate GWs at different sectors of the continent. The EOF1 of Ep comprised more than 50%, the EOF2 ∼20–25%, and the third ∼10–15% of the total GWs variation. The positive variation of GWs energy in the EOF1 is localized in the tropical region from the lower stratosphere to the lower mesosphere and southward below 1.5° S in the upper mesosphere. The spectral analysis of GWs energy showed biannual, annual, semiannual, and 11-year variations at different eigenvectors. Relative Ep (REp) showed an asymmetric hemispheric response to solar flux over South America. The REp response to QBO showed a modulating effect below 70 km and a positive response above 70 km. There is a good positive correlation between the temporal component of EOF2 of Ep and the quasi-biennial oscillation (QBO) at 30 mb and 50 mb in the PC2 temporal variation.
Graphical Abstract
Interference mechanism of plasma self-organization in transparent dielectrics under the intense femtosecond laser pulse exposure
Authors: Bogatskaya A. V. , Volkova E. A. , Popov A. M. 
Published: July 2024

Abstract
A new mechanism of plasma self-organization in transparent dielectrics with wide bandgap exposed to the intense tightly focused laser radiation was revealed, which causes the generation of 3D periodic ring structures with subwavelength period both along the laser pulse propagation and in the radial direction. The mechanism involves formation of dense plasma burst in the pre-focal region that provides efficient scattering of the incident wave. The interference of a plane incident laser wave in the focal region and a divergent reflected one will form the standing wave pattern with local minima and maxima of laser field both in the direction of the incident wave propagation and perpendicular to it producing the ring patterns of effective ionization regions in the dielectric volume. Analytical and numerical simulations of the process of laser wave scattering on a near-spherical plasma object with dimensions both smaller and larger than the laser radiation wavelength are performed to verify the proposed model.
Congenital Hyperinsulinism and Novel KDM6A Duplications -Resolving Pathogenicity With Genome and Epigenetic Analyses
Authors: Männistö Jonna M E , Hopkins Jasmin J , Hewat Thomas I , Nasser Fatima , Burrage Joseph , Dastamani Antonia , Mirante Alice , Murphy Nuala , Rzasa Jessica , Kerkhof Jennifer , Relator Raissa , Johnson Matthew B , Laver Thomas W , Weymouth Luke , Houghton Jayne A L , Wakeling Matthew N , Sadikovic Bekim , Dempster Emma L , Flanagan Sarah E 
Published: July 2024

Abstract

Context
Hyperinsulinemic hypoglycemia (HI) can be the presenting feature of Kabuki syndrome (KS), which is caused by loss-of-function variants in KMT2D or KDM6A. As these genes play a critical role in maintaining methylation status in chromatin, individuals with pathogenic variants have a disease-specific epigenomic profile—an episignature.

Objective
We evaluated the pathogenicity of 3 novel partial KDM6A duplications identified in 3 individuals presenting with neonatal-onset HI without typical features of KS at the time of genetic testing.

Methods
Three different partial KDM6A duplications were identified by routine targeted next-generation sequencing for HI and initially classified as variants of uncertain significance (VUS) as their location, and hence their impact on the gene, was not known. Whole-genome sequencing (WGS) was undertaken to map the breakpoints of the duplications with DNA methylation profiling performed in 2 individuals to investigate the presence of a KS-specific episignature.

Results
WGS confirmed the duplication in proband 1 as pathogenic as it caused a frameshift in the normal copy of the gene leading to a premature termination codon. The duplications identified in probands 2 and 3 did not alter the reading frame, and therefore their significance remained uncertain after WGS. Subsequent DNA methylation profiling identified a KS-specific episignature in proband 2 but not in proband 3.

Conclusion
Our findings confirm a role for KDM6A partial gene duplications in the etiology of KS and highlight the importance of performing in-depth molecular genetic analysis to properly assess the clinical significance of VUS' in the KDM6A gene.
LEAFY and WAPO1 jointly regulate spikelet number per spike and floret development in wheat
Authors: Paraiso Francine , Lin Huiqiong , Li Chengxia , Woods Daniel P. , Lan Tianyu , Tumelty Connor , Debernardi Juan M. , Joe Anna , Dubcovsky Jorge 
Published: July 2024

ABSTRACT
In wheat, the transition of the inflorescence meristem to a terminal spikelet (IM→TS) determines the spikelet number per spike (SNS), an important yield component. In this study, we demonstrate that the plant-specific transcription factor LEAFY (LFY) physically and genetically interacts with WHEAT ORTHOLOG OF APO1 (WAPO1) to regulate SNS and floret development. Loss-of-function mutations in either or both genes result in significant and similar reductions in SNS, as a result of a reduction in the rate of spikelet meristem formation per day. SNS is also modulated by significant genetic interactions between LFY and the SQUAMOSA MADS-box genes VRN1 and FUL2, which promote the IM→TS transition. Single-molecule fluorescence in situ hybridization revealed a downregulation of LFY and upregulation of the SQUAMOSA MADS-box genes in the distal part of the developing spike during the IM→TS transition, supporting their opposite roles in the regulation of SNS in wheat. Concurrently, the overlap of LFY and WAPO1 transcription domains in the developing spikelets contributes to normal floret development. Understanding the genetic network regulating SNS is a necessary first step to engineer this important agronomic trait.
Nursing undergraduates’ experience of participating in the Internet + Nursing Program and their spiritual education needs: A qualitative study from the perspective of the Neuman System Model
Authors: Huang Ying , Dong Xiaotong , Wu Wei , Zhang Haoran , Qi Fei 
Published: July 2024

Objective: This study aimed to explore the qualitative aspects of nursing undergraduates’ experience of participating in the Internet + nursing program and their spiritual education needs from the perspective of the Neuman system model.
Methods: Using a descriptive qualitative study design, twelve full-time undergraduates at Chengde Medical University from June to July 2022 who had completed their clinical internship were interviewed one-on-one, and a purposive sampling method was adopted. Moreover, Colaizzi’s phenomenological method was employed to analyze the data and improve the themes.
Results: In the Internet + nursing program, the lack of spiritual education for undergraduates can be summarized into the following four themes: lack of spiritual consciousness; lack of spiritual education and spiritual nursing knowledge; high demand for spiritual education; and cognition of the current situation of basic nursing education in China and thoughts on incorporating Internet-related technologies into future nursing education.
Conclusion: At the school and hospital level, importance should be placed on the basic education of spirituality and psychological nursing, and appropriate measures should be taken to improve the knowledge level of spirituality and psychological nursing as well as the capacity of spiritual nursing, in order to ensure high-quality nursing services.
doi: https://doi.org/10.12669/pjms.40.8.8822
How to cite this: Huang Y, Dong X, Wu W, Zhang H, Qi F. Nursing undergraduates’ experience of participating in the Internet + Nursing Program and their spiritual education needs: A qualitative study from the perspective of the Neuman System Model. Pak J Med Sci. 2024;40(8):---------. doi: https://doi.org/10.12669/pjms.40.8.8822
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.