bluuebunny/crossref_metadata_2025_split huggingface dataset:
Difference in Developmental Toxicity Among Structurally Similar N‐Phenylimide Herbicides in Rats and Rabbits
Authors: Kawamura Satoshi , Kato Terushige , Kannan Noboru , Fantel Alan G. 
Published: January 2014

BACKGROUNDS‐53482 is an N‐phenylimide herbicide and shows a remarkable species difference in developmental toxicity between rats and rabbits. The herbicide produced embryolethality, teratogenicity (mainly ventricular septal defects and wavy ribs), and growth retardation in rats, but not in rabbits. Our objective in this study was to investigate differences in developmental toxicity among N‐phenylimide compounds structurally similar to S‐53482 to better characterize the developmental effects of S‐53482 on rat and rabbit embryos as part of research investigation to elucidate a mechanism of rat developmental toxicity produced by S‐53482. This paper is part of a series of studies to be published serially.METHODSS‐23121 or S‐23031, both of which are structurally similar to S‐53482, was orally administered to rats and rabbits during fetal organogenesis. Fetuses were obtained by cesarian section and examined for external, visceral, and skeletal alterations.RESULTSS‐23121 produced the similar pattern of developmental toxicity such as embryolethality, teratogenicity, and growth retardation in rats. In contrast, S‐23031 showed no developmental toxicity at 1500 mg/kg. Rabbits were insensitive to all study compounds.CONCLUSIONSThe difference in developmental toxicity in rats was striking among N‐phenylimide herbicides. The mechanism of action of developmental toxicity by S‐53482 should account for the compound‐specific difference as well as species difference between rats and rabbits.
Europäische Bemessungsregeln für Doppelkopfanker als Durchstanzbewehrung
Authors: Ricker Marcus , Häusler Frank 
Published: January 2014

AbstractDoppelkopfanker können als Durchstanzbewehrung in Deckenplatten, Bodenplatten und Einzelfundamenten aus Stahl‐ und Spannbeton verwendet werden. Aufgrund ihrer schlupfarmen Verankerung erreichen Doppelkopfanker im Vergleich zu Bügeln höhere Durchstanzlasten. Ein weiterer Vorteil ist der im Vergleich zu konventioneller Durchstanzbewehrung geringere Verlegeaufwand und eine daraus resultierende Kostenersparnis. Bisher wurde in den meisten europäischen Ländern die Anwendung von Doppelkopfankern als Durchstanzbewehrung durch nationale Zulassungen geregelt. Seit Ende 2012 sind die ersten Europäischen Technischen Zulassungen (ETAs) verfügbar. Diese Zulassungen basieren alle auf dem gleichen Bemessungskonzept, das für eine Anwendung in Verbindung mit EN 1992‐1‐1 entwickelt wurde.Grundsätzlich ist ein Durchstanzversagen von Platten ohne und mit Durchstanzbewehrung zu unterscheiden. In Deckenplatten und Fundamenten mit Durchstanzbewehrung kann ein Versagen inner‐ und außerhalb der durchstanzbewehrten Zone sowie bei Erreichen der Maximaltragfähigkeit auftreten. Die ETAs geben Gleichungen für jede dieser möglichen Versagensarten an. Das Sicherheitsniveau dieser Bemessungsregeln wird anhand eigener Durchstanzversuche und Versuchen aus der Literatur überprüft. Weiterhin werden die Hintergründe zu den einzelnen Regelungen erläutert und Empfehlungen für die praktische Anwendung gegeben.European Technical Approvals provisions for double‐headed studs at shear reinforcementDouble‐headed studs are used as punching shear reinforcement in reinforced or pre‐stressed slabs and footings. Due to an improved anchoring behaviour, double‐headed studs have a higher load capacity than stirrups. Double‐headed studs are quick to install and are therefore more cost‐effective than stirrups. Previously in Europe, national technical approvals specified the design of double‐headed studs. Since the end of 2012, European technical approvals (ETAs) have been available. All approvals are based on the same design method, which is used in combination with EN 1992‐1‐1. It is necessary to distinguish between punching shear failure in slabs and foundations with and without shear reinforcement. In slabs and foundations with shear reinforcement, a failure can occur at maximum load level, in and outside the shear‐reinforced zone. The ETAs provide design equations for all types of failure modes. To quantify the safety level of the design provisions for slabs, footings, and ground slabs with and without shear reinforcement, test evaluations based on a reliable data bank are shown. The paper also provides useful background information and additional design recommendations for applications which are not covered by the design provisions of the ETAs.
Vergleich der nationalen Anhänge der EN 1992‐1‐1 zum Thema Querkraft und Durchstanzen
Authors: Walraven Joost , Gmainer Susanne 
Published: January 2014

AbstractDer Eurocode 2 (EN 1992‐1‐1) beschäftigt sich mit der Bemessung und Konstruktion von Stahlbeton‐ und Spannbetontragwerken. Eine eingehende Betrachtung und der Vergleich der nationalen Anhänge sind notwendig, um die Unterschiede der national festgelegten Berechnungsparameter zu verifizieren. Dieser Aufsatz gibt einen Überblick über die gegenwärtige Situation und zeigt die wesentlichen Unterschiede der nationalen Anhänge der EN 1992‐1‐1 zu den Themen Querkraft und Durchstanzen auf.Shear and Punching Shear verifications in comparison to the national annexes of the Eurocode 2In order to get the Eurocodes accepted, it was necessary to allow national choices with regard to parameters where no agreement between the countries involved could be reached. For the part EN 1992‐1‐1 “Design of concrete structures – Part I: General rules and rules for buildings” altogether 121 parameters have been defined which are subject to national choices. A comparison of the national choices can show where in future easily agreement can be reached. On the other hand parameters can be identified for which significant disagreement exist, which invites to further discussions and even research. In this paper, as an experiment, the nationally defined parameters of 18 countries are compared for the chapters on shear and punching, which subjects are now, for several reasons, again in the centre of interest.
ChemInform Abstract: A Co‐Catalyst‐Loaded Ta3N5 Photoanode with a High Solar Photocurrent for Water Splitting upon Facile Removal of the Surface Layer.
Authors: Li Mingxue , Luo Wenjun , Cao Dapeng , Zhao Xin , Li Zhaosheng , Yu Tao , Zou Zhigang 
Published: January 2014

AbstractTa3N5 photoelectrodes are prepared by oxidation of Ta foils at 550—610 °C in air followed by nitridation at 850 °C in flowing NH3.
ChemInform Abstract: Elusive 2‐Aminofuran Diels—Alder Substrates for a Straightforward Synthesis of Polysubstituted Anilines.
Authors: Neo Ana G. , Bornadiego Ana , Diaz Jesus , Marcaccini Stefano , Marcos Carlos F. 
Published: January 2014

AbstractThe first multicomponent coupling of α,β‐unsaturated carbonyl compounds (I), isocyanides (II) and dienophiles such as maleimides or maleic anhydride (III), based on trapping of unstable intermediate 2‐aminofurans, is described.
ChemInform Abstract: An Efficient Copper‐Catalyzed N‐Arylation of Amides: Synthesis of N‐Arylacrylamides and 4‐Amido‐N‐phenylbenzamides.
Authors: Quan Zheng‐Jun , Xia Hai‐Dong , Zhang Zhang , Da Yu‐Xia , Wang Xi‐Cun 
Published: January 2014

AbstractA novel method using CuSO4/sodium ascorbate as the catalyst system allows the synthesis of various secondary amides including the title amides, which are difficult to obtain by classical methods.
ChemInform Abstract: Synthesis of a New Squarylium Alkylamide Family and Its Organogelation Ability.
Authors: Ohsedo Yutaka , Miyamoto Misao , Tanaka Akihiro , Watanabe Hisayuki 
Published: January 2014

AbstractThe organogelation ability of the new squarylium mono‐ and dialkylamides (I) and (II) in DMF is evaluated.
ChemInform Abstract: Atropodiastereoselective C—H Olefination of Biphenyl p‐Tolyl Sulfoxides with Acrylates.
Authors: Wesch Thomas , Leroux Frederic R. , Colobert Francoise 
Published: January 2014

AbstractThe study shows a proof for the concept that sulfoxides are used both as a directing group and a chiral auxiliary.
ChemInform Abstract: Synthesis of 2,2′‐Bipyrrole‐5‐carboxaldehydes and Their Application in the Synthesis of B‐Ring Functionalized Prodiginines and Tambjamines.
Authors: Kancharla Papireddy , Reynolds Kevin A. 
Published: January 2014

AbstractSeveral synthetic routes for the synthesis of 3‐ and 4‐substituted 2,2′‐bipyrrole‐5‐carboxaldehydes are developed and the products are utilized to synthesize B‐ring functionalized prodiginines [cf.
ChemInform Abstract: Rapid Synthesis of Indole cis‐Enamides via Hydroamidation of Indolic Alkynes.
Authors: Dickson Emma , Copp Brent R. , Barker David 
Published: January 2014

AbstractThe selective synthesis of indolic cis‐enamides (VII) and (IX) via ruthenium‐catalyzed hydroamination of indole acetylenes (IV) with primary amides (V) and (VIII), resp.
ChemInform Abstract: Synthesis of Carbazoles via One‐Pot Copper‐Catalyzed Amine Insertion into Cyclic Diphenyleneiodoniums as a Strategy to Generate a Drug‐Like Chemical Library.
Authors: Zhu Daqian , Liu Qi , Luo Bingling , Chen Meihui , Pi Rongbiao , Huang Peng , Wen Shijun 
Published: January 2014

AbstractCarbazole (IIIc) shows an outstanding ability to protect HT‐22 neuronal cells from the damage induced by neurotoxins glutamate and homocysteic acid.
ChemInform Abstract: Fast CO2 Sequestration, Activation, and Catalytic Transformation Using N‐Heterocyclic Olefins.
Authors: Wang Yan‐Bo , Wang Yi‐Ming , Zhang Wen‐Zhen , Lu Xiao‐Bing 
Published: January 2014

AbstractThis method uses a N‐heterocyclic olefin/carbon dioxide adduct as organocatalyst for the synthesis of dioxolane derivatives.
ChemInform Abstract: Design, Synthesis, and in vitro hMAO‐B Inhibitory Evaluation of Some 1‐Methyl‐3,5‐diphenyl‐4,5‐dihydro‐1H‐pyrazoles.
Authors: Fioravanti Rossella , Desideri Nicoletta , Biava Mariangela , Proietti Monaco Luca , Grammatica Laura , Yanez Matilde 
Published: January 2014

AbstractThe synthesis of 30 title compounds of type (III) or (VI) is outlined and the compounds are screened for their inhibitory efficacy towards the two hMAO isoforms.
ChemInform Abstract: Synthesis and Biological Evaluation of Some N‐Arylpyrazoles and Pyrazolo[3,4‐d]pyridazines as Antiinflammatory Agents.
Authors: El‐Sabbagh Osama I. , Mostafa Samia , Abdel‐Aziz Hatem A. , Ibrahim Hany S. , Elaasser Mahmoud M. 
Published: January 2014

AbstractA series of pyrazole bis‐chalcone derivatives (V) and pyrazolopyridazines (VI) and (VIII) are synthesized from diacetylpyrazoles (III) and evaluated for their antiinflammatory, ulcerogenic and cyclooxygenase inhibitory activities.
ChemInform Abstract: Carbene Adduct of Cyclopalladated Ferrocenylimine‐Assisted Synthesis of Aminopyridine Derivatives by the Amination of Chloropyridines with Primary and Secondary Amines.
Authors: Mu Bing , Li Jingya , Wu Yangjie 
Published: January 2014

AbstractThis presents a catalyst for the Buchwald‐Hartwig amination of chloropyridines.
ChemInform Abstract: Copper(II)‐Catalyzed Trifluoromethylation of N‐Aryl Imines.
Authors: Zhang Yong‐Qiang , Liu Ji‐Dan , Xu Hao 
Published: January 2014

AbstractA new method for the trifluoromethylation of 8‐aminoquinoline derived N‐aryl imines, generated in situ, without the use of fluoride or HF‐based activators is described.
ChemInform Abstract: Copper‐Catalyzed Aerobic Oxidative Carbocyclization—Ketonization Cascade: Selective Synthesis of Quinolinones.
Authors: Xie Peng , Wang Zhi‐Qiang , Deng Guo‐Bo , Song Ren‐Jie , Xia Jia‐Dong , Hu Ming , Li Jin‐Heng 
Published: January 2014

AbstractA wide range of quinolinones is prepared using carbocyclization of α‐C(sp3)‐H bonds of amides with alkynes followed by ketonization of the alkynes.
ChemInform Abstract: An Efficient Route to Chiral N‐Heterocycles Bearing a C—F Stereogenic Center via Asymmetric Hydrogenation of Fluorinated Isoquinolines.
Authors: Guo Ran‐Ning , Cai Xian‐Feng , Shi Lei , Ye Zhi‐Shi , Chen Mu‐Wang , Zhou Yong‐Gui 
Published: January 2014

AbstractThe first successful example of an asymmetric hydrogenation of fluorinated heteroaromatics with high chemo‐, diastereo‐ and enantioselectivity is described.
ChemInform Abstract: Metal‐Free Intramolecular Carbocyanation of Activated Alkenes: Functionalized Nitriles Bearing β‐Quaternary Carbon Centers.
Authors: Chen Jianming , Zou Gongfeng , Liao Weiwei 
Published: January 2014

AbstractThis new title reaction provides an easy and facile access to a wide range of different functionalized quinoline and isoquinoline derivatives from readily available starting materials under mild conditions.
ChemInform Abstract: Alkaloid Inspired Spirocyclic Oxindoles from 1,3‐Dipolar Cycloaddition of Pyridinium Ylides.
Authors: Day Jonathan , Uroos Maliha , Castledine Richard A. , Lewis William , McKeever‐Abbas Ben , Dowden James 
Published: January 2014

AbstractCycloaddition reactions between pyridinium ylides and 3‐alkenyl oxindoles (I) proceed in high yields and with good regio‐ and diastereoselectivity.
ChemInform Abstract: Cobalt‐Catalyzed Oxidative [3 + 2] Cycloaddition Reactions: An Efficient Synthesis of Pyrrolo‐ and Imidazo‐[2,1‐a]isoquinolines.
Authors: Feng Chengtao , Su Ji‐Hu , Yan Yizhe , Guo Fengfeng , Wang Zhiyong 
Published: January 2014

AbstractThe cobalt‐catalyzed reaction of tetrahydroquinoline (I) with in situ generated aldimines leads to 5,6‐dihydroimidazo[2,1‐a]isoquinolines (III), whilst the reaction of tetrahydroquinolines (IV) with N‐tosyl aldimines as dipolarophiles affords a variety of hexahydroimidazo[2,1‐a]isoquinolines (VI).
ChemInform Abstract: Triterpenoids from the Stem Bark of Melia toosendan and Determination of Their Absolute Configurations at C(24)
Authors: Zhang Yi , Tang Chun‐Ping , Ke Chang‐Qiang , Yao Sheng , Ye Yang 
Published: January 2014

Abstractisolation and structure elucidation of meliasenins S‐X
ChemInform Abstract: One‐Pot Synthesis and Cytotoxicity Studies of New Mannich Base Derivatives of Polyether Antibiotic—Lasalocid Acid.
Authors: Huczynski Adam , Rutkowski Jacek , Borowicz Izabela , Wietrzyk Joanna , Maj Ewa , Brzezinski Bogumil 
Published: January 2014

Abstract7 Title compounds of type (IV) are prepared whereby, (IVb‐c) show very good anticancer activity.
ChemInform Abstract: Formation of Low Density Hydrous Iron Oxide via Conformal Transformation of MIL‐53(Fe).
Authors: Marken Frank , et al. et al. 
Published: January 2014

AbstractCrystalline MIL‐53(Fe), (Fe(OH)(bdc)·DMF, bdc: 1,4‐benzenedicarboxylate), reacts within seconds with 0.1M aqueous NaOH at room temperature in a hydrolytic transformation to give low density hydrous iron oxide and hematite products with the crystal shape maintained but of complete amorphous nature.
ChemInform Abstract: The Acidity of Zeolites: Concepts, Measurements and Relation to Catalysis: A Review on Experimental and Theoretical Methods for the Study of Zeolite Acidity
Authors: Derouane E. G. , Vedrine J. C. , Pinto R. Ramos , Borges P. M. , Costa L. , Lemos M. A. N. D. A. , Lemos F. , Ribeiro F. Ramoa 
Published: January 2014

AbstractReview: 365 refs.
ChemInform Abstract: Magnetic Properties of MM′X (M = Mn, M′ = 3d or 4d Metal, X = P, As, Si, Ge) Compounds with Hexagonal or Orthorhombic Crystal Structure
Authors: Zach Ryszard , Tobola Janusz , Chajec Wieslaw , Fruchart Daniel , Ono Fumihisa 
Published: January 2014

AbstractReview: 16 refs.
Optimizing bladder cancer locoregional failure risk stratification after radical cystectomy using SWOG 8710
Authors: Christodouleas John P. , Baumann Brian C. , He Jiwei , Hwang Wei‐Ting , Tucker Kai N. , Bekelman Justin E. , Tangen Catherine M. , Lerner Seth P. , Guzzo Thomas J. , Malkowicz S. Bruce 
Published: January 2014

BACKGROUNDClinical trials of radiation after radical cystectomy (RC) and chemotherapy for bladder cancer are in development, but inclusion and stratification factors have not been clearly established. In this study, the authors evaluated and refined a published risk stratification for locoregional failure (LF) by applying it to a multicenter patient cohort.METHODSThe original stratification, which was developed using a single‐institution series, produced 3 subgroups with significantly different LF risk based on pathologic tumor (pT) classification and the number of lymph nodes identified. This model was then applied to patients in Southwest Oncology Group (SWOG) 8710, a randomized trial of RC with or without chemotherapy. LF was defined as any pelvic failure before or within 3 months of distant failure.RESULTSPatients in the development cohort and the SWOG cohort had significantly different baseline characteristics. The original risk model was not fully validated in the SWOG cohort, because lymph node yield was not as strongly associated with LF as in the development cohort. Regression analysis indicated that margin status could improve the model. A revised stratification using pT classification, margin status, and the number of lymph nodes identified produced 3 subgroups with significantly different LF risk in both cohorts: low risk (≤pT2), intermediate risk (≥pT3 with negative margins AND ≥10 lymph nodes identified), and high risk (≥pT3 with positive margins OR <10 lymph nodes identified) with 5‐year LF rates of 8%, 20%, and 41%, respectively, in the SWOG cohort and 8%, 19%, and 41%, respectively, in the development cohort.CONCLUSIONSA model incorporating pT classification, margin status, and the number of lymph nodes identified stratified LF risk in 2 different RC populations and may inform the design of future trials. Cancer 2014;120:1272–1280. © 2014 American Cancer Society.
Elevated levels of mitochondrion‐associated autophagy inhibitor LRPPRC are associated with poor prognosis in patients with prostate cancer
Authors: Jiang Xianhan , Li Xun , Huang Hai , Jiang Funeng , Lin Zhuoyuan , He Huichan , Chen Yanru , Yue Fei , Zou Jing , He Yongzhong , You Pan , Wang Wenwei , Yang Weiqing , Zhao Haibo , Lai Yiming , Wang Fen , Zhong Weide , Liu Leyuan 
Published: January 2014

BACKGROUNDAutophagy has recently been found to play important roles in tumorigenesis and leucine‐rich pentatricopeptide repeat motif‐containing protein (LRPPRC) has been identified as an inhibitor that suppresses autophagy and mitophagy and maintains mitochondrial activity. The authors hypothesized that LRPPRC levels can be used as a biomarker for the diagnosis and prognosis of prostate cancer.METHODSImmunochemistry analysis was performed to evaluate the levels of LRPPRC in 112 samples collected from patients with prostate adenocarcinoma (PCa) and 38 samples from patients with benign prostatic hyperplasia (BPH) who were enrolled in hospitals in Guangzhou City, China and were followed for 10 years.RESULTSSignificantly higher levels of LRPPRC were found in PCa samples compared with BPH samples. Greater than 75% of patients with PCa demonstrated high levels of LRPPRC whereas only 10% of patients with BPH were found to have similar levels of LRPPRC. The levels of LRPPRC were found to be positively correlated with tumor grade, metastasis, and serum prostate‐specific antigen level, but were negatively correlated with hormone therapy sensitivity after 2 years of surgery and overall survival. The association between high levels of LRPPRC and late‐stage PCa or hormone therapy insensitivity was confirmed in tissue samples collected from prostate‐specific phosphatase and tensin homolog (PTEN)‐/‐ mice or hormone‐dependent and hormone‐independent PCa cell lines.CONCLUSIONSLRPPRC levels may be used as an independent biomarker for patients with PCa at a late stage with poor prognosis. Cancer 2014;120:1228–1236. © 2014 American Cancer Society.
A compressive sensing‐based network tomography approach to estimating origin–destination flow traffic in large‐scale backbone networks
Authors: Nie Laisen , Jiang Dingde 
Published: January 2014

SummaryA traffic matrix can exhibit the volume of network traffic from origin nodes to destination nodes. It is a critical input parameter to network management and traffic engineering, and thus it is necessary to obtain accurate traffic matrix estimates. Network tomography method is widely used to reconstruct end‐to‐end network traffic from link loads and routing matrix in a large‐scale Internet protocol backbone networks. However, it is a significant challenge because solving network tomography model is an ill‐posed and under‐constrained inverse problem. Compressive sensing reconstruction algorithms have been well known as efficient and precise approaches to deal with the under‐constrained inference problem. Hence, in this paper, we propose a compressive sensing‐based network traffic reconstruction algorithm. Taking into account the constraints in compressive sensing theory, we propose an approach for constructing a novel network tomography model that obeys the constraints of compressive sensing. In the proposed network tomography model, a framework of measurement matrix according to routing matrix is proposed. To obtain optimal traffic matrix estimates, we propose an iteration algorithm to solve the proposed model. Numerical results demonstrate that our method is able to pursuit the trace of each origin–destination flow faithfully. Copyright © 2014 John Wiley & Sons, Ltd.
Influence of air temperature on the first flowering date of Prunus yedoensis Matsum
Authors: Shi Peijian , Chen Zhenghong , Yang Qingpei , Harris Marvin K. , Xiao Mei 
Published: January 2014

AbstractClimate change is expected to have a significant effect on the first flowering date (FFD) in plants flowering in early spring. Prunus yedoensis Matsum is a good model plant for analyzing this effect. In this study, we used a degree day model to analyze the effect of air temperatures on the FFDs of P. yedoensis at Wuhan University from a long‐time series from 1951 to 2012. First, the starting date (=7 February) is determined according to the lowest correlation coefficient between the FFD and the daily average accumulated degree days (ADD). Second, the base temperature (=−1.2°C) is determined according to the lowest root mean square error (RMSE) between the observed and predicted FFDs based on the mean of 62‐year ADDs. Finally, based on this combination of starting date and base temperature, the daily average ADD of every year was calculated. Performing a linear fit of the daily average ADD to year, we find that there is an increasing trend that indicates climate warming from a biological climatic indicator. In addition, we find that the minimum annual temperature also has a significant effect on the FFD of P. yedoensis using the generalized additive model. This study provides a method for analyzing the climate change on the FFD in plants' flowering in early spring.