bluuebunny/crossref_metadata_2025_split huggingface dataset:
Haemoptysis in adults: a 5-year study using the French nationwide hospital administrative database
Authors: Abdulmalak Caroline , Cottenet Jonathan , Beltramo Guillaume , Georges Marjolaine , Camus Philippe , Bonniaud Philippe , Quantin Catherine 
Published: May 2015

Haemoptysis is a serious symptom with various aetiologies. Our aim was to define the aetiologies, outcomes and associations with lung cancer in the entire population of a high-income country.This retrospective multicentre study was based on the French nationwide hospital medical information database collected over 5 years (2008–2012). We analysed haemoptysis incidence, aetiologies, geographical and seasonal distribution and mortality. We studied recurrence, association with lung cancer and mortality in a 3-year follow-up analysis.Each year, ∼15 000 adult patients (mean age 62 years, male/female ratio 2/1) were admitted for haemoptysis or had haemoptysis as a complication of their hospital stay, representing 0.2% of all hospitalised patients. Haemoptysis was cryptogenic in 50% of cases. The main aetiologies were respiratory infections (22%), lung cancer (17.4%), bronchiectasis (6.8%), pulmonary oedema (4.2%), anticoagulants (3.5%), tuberculosis (2.7%), pulmonary embolism (2.6%) and aspergillosis (1.1%). Among incident cases, the 3-year recurrence rate was 16.3%. Of the initial cryptogenic haemoptysis patients, 4% were diagnosed with lung cancer within 3 years. Mortality rates during the first stay and at 1 and 3 years were 9.2%, 21.6% and 27%, respectively.This is the first epidemiological study analysing haemoptysis and its outcomes in an entire population. Haemoptysis is a life-threatening symptom unveiling potentially life-threatening underlying conditions.
Serum 25-hydroxyvitamin D level, smoking and lung function in adults: the HUNT Study
Authors: Larose Tricia L. , Brumpton Ben M. , Langhammer Arnulf , Camargo Carlos A. , Chen Yue , Romundstad Pål , Mai Xiao-Mei 
Published: May 2015

The association between serum 25-hydroxyvitamin D (25(OH)D) level and lung function changes in the general population remains unclear.We conducted cross-sectional (n=1220) and follow-up (n=869) studies to investigate the interrelationship of serum 25(OH)D, smoking and lung function changes in a random sample of adults from the Nord-Trøndelag Health (HUNT) Study, Norway.Lung function was measured using spirometry and included forced expiratory volume in 1 s (FEV1) % predicted, forced vital capacity (FVC) % pred and FEV1/FVC ratio. Multiple linear and logistic regression models estimated the adjusted difference in lung function measures or lung function decline, adjusted odds ratios for impaired lung function or development of impaired lung function and 95% confidence intervals.40% of adults had serum 25(OH)D levels <50 nmol·L−1. Overall, those with a serum 25(OH)D level <50 nmol·L−1showed worse lung function and increased odds of impaired lung function compared to the ≥50 nmol·L−1group. These associations tended to be stronger among ever-smokers, including greater decline in FEV1/FVC ratio and greater odds of the development of impaired lung function (FEV1/FVC <70% OR 2.4, 95% CI 1.2–4.9). Associations among never-smokers were null. Results from cross-sectional and follow-up studies were consistent. There were no associations between serum 25(OH)D levels and lung function or lung function changes in never-smokers, whereas significant associations were observed in ever-smokers.
Transcriptome profiling of the spl5 mutant reveals that SPL5 has a negative role in the biosynthesis of serotonin for rice disease resistance
Authors: Jin Bin , Zhou Xinru , Jiang Baolin , Gu Zhimin , Zhang Pinghua , Qian Qian , Chen Xifeng , Ma Bojun 
Published: May 2015

AbstractBackgroundRice mutant,spl5(spotted leaf 5), has spontaneous hypersensitive-like lesions on its leaves and shows enhanced resistance to pathogens, indicating thatSPL5plays a role in programmed cell death (PCD) and disease resistance. To understand the molecular mechanism ofSPL5gene, we investigated the transcriptome profiles of thespl5mutant leaves with few lesions (FL) and leaves with many lesions (ML) compared to the wild-type (WT) leaves respectively by microarray.ResultsThe data from microarray revealed that 243 and 896 candidate genes (Fold change ≥ 3.0) were up- or down-regulated in thespl5-FL andspl5-ML, respectively, and a large number of these genes involved in biotic defense responses or reactive oxygen species (ROS) metabolism. Interestingly, according to our microarray and real-time PCR assays, the expressions of a transcription factorOsWRKY14and genes responsible for the biosynthesis of serotonin, anthranilate synthase (AS), indole-3-glycerolphosphate synthase (IGPS), tryptophan synthase (TS) and tryptophan decarboxylase (TDC) were significantly up-regulated in thespl5mutant. It has been reported previously thatTSandTDCexpressions are regulated byOsWRKY14in rice, which raises the possibility thatOsWRKY14regulates serotonin production through the up-regulation ofTSandTDC. Our HPLC analysis further confirmed that serotonin levels were higher in the leaves ofspl5mutant than that in WT.ConclusionsSince the serotonin plays a critical role in inducing disease-resistance, the increased serotonin level may contribute, at least partly, to the disease resistance inspl5. TheSPL5gene may act as a negative regulatory factor activating the serotonin metabolic pathway, and these results might provide a new insight into thespl5-induced defense response mechanisms in plants.
Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression
Authors: Strogantsev Ruslan , Krueger Felix , Yamazawa Kazuki , Shi Hui , Gould Poppy , Goldman-Roberts Megan , McEwen Kirsten , Sun Bowen , Pedersen Roger , Ferguson-Smith Anne C. 
Published: May 2015

Abstract
Background
Selective maintenance of genomic epigenetic imprints during pre-implantation development is required for parental origin-specific expression of imprinted genes. The Kruppel-like zinc finger protein ZFP57 acts as a factor necessary for maintaining the DNA methylation memory at multiple imprinting control regions in early mouse embryos and embryonic stem (ES) cells. Maternal-zygotic deletion of ZFP57 in mice presents a highly penetrant phenotype with no animals surviving to birth. Additionally, several cases of human transient neonatal diabetes are associated with somatic mutations in the ZFP57 coding sequence.

Results
Here, we comprehensively map sequence-specific ZFP57 binding sites in an allele-specific manner using hybrid ES cell lines from reciprocal crosses between C57BL/6J and Cast/EiJ mice, assigning allele specificity to approximately two-thirds of all binding sites. While half of these are biallelic and include endogenous retrovirus (ERV) targets, the rest show monoallelic binding based either on parental origin or on genetic background of the allele. Parental-origin allele-specific binding is methylation-dependent and maps only to imprinting control differentially methylated regions (DMRs) established in the germline. We identify a novel imprinted gene, Fkbp6, which has a critical function in mouse male germ cell development. Genetic background-specific sequence differences also influence ZFP57 binding, as genetic variation that disrupts the consensus binding motif and its methylation is often associated with monoallelic expression of neighboring genes.

Conclusions
The work described here uncovers further roles for ZFP57-mediated regulation of genomic imprinting and identifies a novel mechanism for genetically determined monoallelic gene expression.
A multi-label approach to target prediction taking ligand promiscuity into account
Authors: Afzal Avid M , Mussa Hamse Y , Turner Richard E , Bender Andreas , Glen Robert C 
Published: May 2015

AbstractBackgroundAccording to Cobanoglu et al., it is now widely acknowledged that the single target paradigm (one protein/target, one disease, one drug) that has been the dominant premise in drug development in the recent past is untenable. More often than not, a drug-like compound (ligand) can be promiscuous – it can interact with more than one target protein.In recent years, inin silicotarget prediction methods the promiscuity issue has generally been approached computationally in three main ways: ligand-based methods; target-protein-based methods; and integrative schemes. In this study we confine attention to ligand-based target prediction machine learning approaches, commonly referred to astarget-fishing.Thetarget-fishingapproaches that are currently ubiquitous in cheminformatics literature can be essentially viewed as single-label multi-classification schemes; these approaches inherently bank on the single target paradigm assumption that a ligand can zero in on one single target. In order to address the ligand promiscuity issue, one might be able to casttarget-fishingas a multi-label multi-class classification problem. For illustrative and comparison purposes, single-label and multi-label Naïve Bayes classification models (denoted here by SMM and MMM, respectively) fortarget-fishingwere implemented. The models were constructed and tested on 65,587 compounds/ligands and 308 targets retrieved from the ChEMBL17 database.ResultsOn classifying 3,332 test multi-label (promiscuous) compounds, SMM and MMM performed differently. At the 0.05 significance level, a Wilcoxon signed rank test performed on the paired target predictions yielded by SMM and MMM for the test ligands gave a p-value < 5.1 × 10−94and test statistics value of 6.8 × 105, in favour of MMM. The two models performed differently when tested on four datasets comprising single-label (non-promiscuous) compounds; McNemar’s test yieldedχ2values of 15.657, 16.500 and 16.405 (with corresponding p-values of 7.594 × 10−05, 4.865 × 10−05and 5.115 × 10−05), respectively, for three test sets, in favour of MMM. The models performed similarly on the fourth set.ConclusionsThe target prediction results obtained in this study indicate that multi-label multi-class approaches are more apt than the ubiquitous single-label multi-class schemes when it comes to the application of ligand-based classifiers totarget-fishing.
The contractome – a systems view of actomyosin contractility in non-muscle cells
Authors: Zaidel-Bar Ronen , Zhenhuan Guo , Luxenburg Chen 
Published: May 2015

ABSTRACT
Actomyosin contractility is a highly regulated process that affects many fundamental biological processes in each and every cell in our body. In this Cell Science at a Glance article and the accompanying poster, we mined the literature and databases to map the contractome of non-muscle cells. Actomyosin contractility is involved in at least 49 distinct cellular functions that range from providing cell architecture to signal transduction and nuclear activity. Containing over 100 scaffolding and regulatory proteins, the contractome forms a highly complex network with more than 230 direct interactions between its components, 86 of them involving phosphorylation. Mapping these interactions, we identify the key regulatory pathways involved in the assembly of actomyosin structures and in activating myosin to produce contractile forces within non-muscle cells at the exact time and place necessary for cellular function.
Narody Kraju Rad
Authors: Duda Katarzyna 
Published: May 2015

The nations of Soviet Union. The coexistence and distraction of cultures (the literary output of Ludmila Ulitskaya)
After the October Revolution different nations were forced to live together on the area of totalitarian Soviet Union. Their history got worse after the Second World War when Soviet soldiers and especially Stalyn were considered as winners and in this way they cold “colonise” new countries. Their citizens wanted to regain freedom in the 60’s and 70’s od twentieth century. They were called dissidents. One of the most famous modern Russian writers who presents these subject matters is Ludmila Ulitskaya – the representative of new realism whose books have been translated into 25 languages. In her novels and short stories she concentrates mainly on the silmilarities and differences between The Russians and other nations being under communistic control. Ulitskaya shows that some of them wanted to keep their identity by looking after their own tradition, religion, customs. The novelist tries to prove that it is possible to coexist with each other if you respect different habits and culture and if you desire to communicate with others using constructive dialogue.
Współczesne kino francuskie wobec pamięci postkolonialnej
Authors: Kamecka Małgorzata 
Published: May 2015

Contemporary French Cinema Facing Postcolonial Memories
For years little has been said the French public discourse about North and West African contribution to the World War II efforts, the sacrifice in blood of their soldiers was mentioned only rarely and occasionally. However, filmmakers embraced this topic unfamiliar to the public. Rachid Bouchareb – a French director of Algerian descent – is one of them. His film Indigènes (2006) is a tribute of sorts to the “forgotten heroes”, who have lost their lives fighting Germans in the south of France and later Alsace. By portraying four soldiers, the artist poses important questions regarding topics such as ethnicity, equality, discrimination, and racism, but also that of being forsaken, leaving an emptiness in the collective mind of a nation. The author describes the attitude of contemporary French filmmakers towards the postcolonial past and themes of ethnicity, concentrating on a film by Rachid Bouchareb. The picture seems to be especially relevant from the point of mutual relations between ethnicity, the politics and culture.
Flamandowie i Walonowie – dwa narody w jednym państwie: polityczne i kulturowe dylematy Belgów
Authors: Klepka Rafał 
Published: May 2015

Flemings and Walloons – Two Nations in One State: the Political and Cultural Dilemmas of the Belgians
Belgium often is of interest to social scientists and the public. This is not merely a consequence of the fact that Brussels is the political heart of Europe. Difficulties with the appointment of the government, the extreme multi‑party system, disputes about the competence of Communities and Regions, the gradual social and cultural divergence between the Flemish and the Walloons are only the most important problems of modern Belgium. Initially, monolingual, through Flemish Movement’s activities, Belgium became a state that recognizes Dutch. Successive reforms have resulted in federalisation of the state. These changes do not resolve the problems of Belgium. Cultural diversity and political instability still provoke questions about the future of Belgium.
Pamięć jako narzędzie walki w konfliktach etnicznych
Authors: Szczecińska-Musielak Ewa 
Published: May 2015

Is Social Memory used as a Weapon in Ethnic Conflicts? Northern Ireland Casus
In case of ethnic conflicts, groups may use memories or symbols of casualties or events which happened during conflict, as a specific symbolic weapon. Weapon addressed to the opponent, usually “the other” group defined as “enemy”, but inthe same time as a message addressed to “my” group. Visual displays of Ulster conflict – murals, flags and emblems, painted kerbstones – have been used not only to create patterns of social memory and remembering but also social‑ethnic group identity. These visual displays play significant role in constructing Belfast landscape and Belfast “ethnic identity”.
“Take Two” Reviews Film
Authors: Herzog Matt , Zera Caitlin 
Published: May 2015

Abstract
We'll Meet Again: Musical Design in the Films of Stanley Kubrick, Kate McQuinston, (2013) New York: Oxford University Press, 256pp., ISBN: 9780199767663 (hbk), $99.00
We'll Meet Again: Musical Design in the Films of Stanley Kubrick, Kate McQuinston, (2013) New York: Oxford University Press, 256pp., ISBN: 9780199767663 (hbk), $99.00
Optimization of Biodiesel Ultrasound-Assisted Synthesis from Castor Oil Using Response Surface Methodology (RSM)
Authors: Sabzimaleki Mohammadreza , Ghobadian Barat , Mazloom Farsibaf Mohsen , Najafi Gholamhassan , Dehghani Soufi Masoud , Mohammad Safieddin Ardebili Seyed 
Published: May 2015

Abstract
Production of biodiesel from castor oil (CO) using ultrasound-assisted has been investigated in this study. The objective of the present work was therefore to determine the relationship between various important parameters of the alkaline-catalyzed transesterification process to obtain a high reaction yield in a short time. The response surface methodology (RSM) was used to statistically analyze and optimize the operating parameters of the process. A central composite design (CCD) was approved to study the effects of the reaction time, the methanol to oil molar ratio, the ultrasonic cycle and the ultrasonic amplitude on reaction yield. The optimum conditions for alkaline-catalyzed transesterification of CO was found to be a reaction time of 540 s, methanol to oil molar ratio of 8.15:1,ultrasonic cycle of 0.73% and ultrasonic amplitude 64.34%. By exerting the calculated optimum condition in the process, the reaction yield reached 87.0494%. The results from the RSM analysis indicated that the reaction time has the most significant effect on the reaction yield.
The milestones in twenty years of processing instruction research
Authors: Lee James F. 
Published: May 2015

AbstractVanPatten and Cadierno (1993) published the first empirical investigation on the effects of processing instruction just over twenty years ago. This work inspired many, many more in subsequent years and continues to inspire research to this day, as evidenced by the studies gathered in this special edition. The purpose of this paper is to identify the milestones among the many processing instruction studies. Each study marks a significant development in the processing instruction research program.
Deconstructing PI for the ages: Explicit instruction vs. practice in young and older adult bilinguals
Authors: Cox Jessica G. , Sanz Cristina 
Published: May 2015

AbstractThe current study considered effects of PI (explicit information and practice) in two populations: older (age 60+) and young adults (age 19–27), all of whom were late English/Spanish bilinguals. Twenty-one participants completed a computer-based lesson on Latin morphosyntax, namely the assignment of the thematic roles
Investigation of autoimmune diseases accompanying Hashimoto’s thyroiditis in children and adolescents and evaluation of cardiac signs
Authors: Baş Veysel Nijat , Yılmaz Agladioglu Sebahat , Özgür Senem , Karademir Selmin , Aycan Zehra 
Published: May 2015

AbstractIn the present study, it was aimed to investigate the concomitance of additional cardiac problems, mainly mitral valve prolapse, in adolescents and pediatric patients with Hashimoto’s thyroiditis, by screening autoimmune markers.Fifty-seven euthyroid patients, who applied to the Pediatric Endocrinology clinic at our institution with marked symptoms of hypothyroidism at the time of diagnosis, and were diagnosed and treated for Hashimoto’s thyroiditis, were included in the present study. All patients were evaluated by performing non-organ specific autoantibodies which could be tested at our institution, thyroid ultrasonography, two-dimensional echocardiography, and 24-h holter monitorization.Of the 57 cases with Hashimoto’s thyroiditis, 48 (84.2%) were female, and nine (15.8%) were male. In the echocardiographic evaluation, mitral valve problems were detected in 10 (17.5%) of all cases; mitral valve prolapse was diagnosed in eight (seven females and one male) cases, and mitral insufficiency was diagnosed in two female cases. First-degree atrioventricular block was observed in only two patients during 24-h holter monitorization. Different non-organ specific autoantibody positivity was distributed as antinuclear antibody in 15 (26.3%) cases, anticardiolipin IgG in two cases, anticardiolipin IgM in three cases, tissue transglutaminase IgA in one, glutamic acid decarboxylase in one, anti-insulin antibody in four cases, antiphospholipid IgG in one, and antiphospholipid IgM in one case.It should be underlined that patients with Hashimoto’s thyroiditis should to be followed up closely for mitral valve prolapse and accompanying autoimmune diseases.
Ideas, Not Interests or Institutions, Caused the Great Enrichment
Authors: McCloskey Deirdre N. 
Published: May 2015

Abstract
The question is why the Great Enrichment of 4,000 or 10,000 percent increase in material scope per person, 1800 to the present, awaited 1800. The answer lies with ideas, ideologies, sociology, habits of lip, conversation, ethics – in short, how people viewed each other. They began rather suddenly in northwestern Europe from 1600 or so to view each other as having liberty and dignity, which is to say the legal ability to have a go and and social honor in doing so. Not that material causes do not matter. But none of material causes are unique to Europe or the modern world – coal was use anciently in China on a large scale, trade was larger in the Indian Ocean than anywhere until the nineteenth century, property rights were fully protected under Roman law, and yet none of these places had a great enrichment. There is nothing unscientific about emphasizing ideas. The unscientific attitude would be to assume, as economists are inclined to do, that only incentives of a straightforwardly Samuelsonian sort can matter. The unscientific attitude characterizes many of a neo-institutionalist tendency.
Acid-Catalyzed Dehydration of Fructose to 5-(Hydroxymethyl)furfural
Authors: Qiao Yunxiang , Theyssen Nils , Hou Zhenshan 
Published: May 2015

AbstractHydroxymethylfurfural (abbreviated as HMF), also 5-(hydroxymethyl)furfural, is an organic compound derived from dehydration of certain sugars. HMF is primarily considered as a starting material for liquid transportation fuels and polyester building block chemicals. The most convenient synthetic method of HMF is based on acidcatalyzed triple dehydration of fructose. Although there are many studies about fructose dehydration to 5-HMF since this field started to be investigated, it is necessary to provide a new review about fructose dehydration to 5-HMF. In the following, we will make a summary (in detail) of catalytic systems of fructose dehydration to HMF achieved by different acid catalysts, including mineral and organic acids, metal complexes, heteropoly acid-based materials, Ionic Liquids, ion-exchange resins, zeolites, functionalized carbonaceous materials and mesoporous silica materials. It has been demonstrated that nearly full conversion of fructose and 100% HMF selectivity could be obtained with some acidic catalytic systems up to now.