bluuebunny/crossref_metadata_2025_split huggingface dataset:
H3K4 monomethylation dictates nucleosome dynamics and chromatin remodeling at stress-responsive genes
Authors: Nadal-Ribelles Mariona , Mas Glòria , Millán-Zambrano Gonzalo , Solé Carme , Ammerer Gustav , Chávez Sebastián , Posas Francesc , de Nadal Eulàlia 
Published: March 2015

Abstract
Chromatin remodeling is essential for proper adaptation to extracellular stimuli. The p38-related Hog1 SAPK is an important regulator of transcription that mediates chromatin remodeling upon stress. Hog1 targets the RSC chromatin remodeling complex to stress-responsive genes and rsc deficient cells display reduced induction of gene expression. Here we show that the absence of H3K4 methylation, either achieved by deletion of the SET1 methyltransferase or by amino acid substitution of H3K4, bypasses the requirement of RSC for stress-responsive gene expression. Monomethylation of H3K4 is specifically inhibiting RSC-independent chromatin remodeling and thus, it prevents osmostress-induced gene expression. The absence of H3K4 monomethylation permits that the association of alternative remodelers with stress-responsive genes and the Swr1 complex (SWR-C) is instrumental in the induction of gene expression upon stress. Accordingly, the absence of SWR-C or histone H2A.Z results in compromised chromatin remodeling and impaired gene expression in the absence of RSC and H3K4 methylation. These results indicate that expression of stress-responsive genes is controlled by two remodeling mechanisms: RSC in the presence of monomethylated H3K4, and SWR-C in the absence of H3K4 monomethylation. Our findings point to a novel role for H3K4 monomethylation in dictating the specificity of chromatin remodeling, adding an extra layer of regulation to the transcriptional stress response.
Improving Survival in Patients Treated for a Lung Cancer Using Self-Evaluated Symptoms Reported Through a Web Application
Authors: Denis Fabrice , Yossi Senna , Septans Anne-Lise , Charron Alexandre , Voog Eric , Dupuis Olivier , Ganem Gérard , Pointreau Yoann , Letellier Christophe 
Published: March 2015

Objectives:
We retrospectively compared survivals in patients with a lung cancer history and followed by the so-called sentinel Web-application that allows early detection of relapse and early palliative care initiation versus a conventional follow-up in our center.

Methods:
The survival in 98 consecutive patients with lung cancer was assessed. The first part of them (the control arm) was retrospectively recruited between March 2011 and August 2012. The second half of them (the experimental arm) was prospectively recruited between August 2012 and December 2013 to weekly fill a form of 11 self-assessed symptoms, then processed by the “sentinel” Web-application. Data were sent to this sentinel application in real-time between planned visits. An email alert was sent to the oncologist when self-scored symptoms matched some predefined criteria. Follow-up visit and imaging were then organized after a phone call for confirming the suspect symptoms. In the control arm (49 patients), a common follow-up was applied (visit and imaging every 2 to 6 mo according to stage of tumor and kind of treatment).

Results:
Median follow-up duration was 12.3 months in the experimental arm and 16.7 months in the control arm (P=0.27). Survival was significantly better in the sentinel arm than in the control arm (P=0.0014). Median survival was 16.7 months in the control arm and 22.4 months in the experimental arm. One-year survival was 86.6% in the experimental arm and 59.1% in the control arm.

Conclusions:
Survival may be improved by early detection of relapse and early palliative care initiation by using sentinel-like Web-application.
RNAseq in the mosquito maxillary palp: a little antennal RNA goes a long way
Authors: Rinker David C. , Zhou Xiaofan , Pitts Ronald Jason , Jones Patrick L. , Rokas Antonis , Zwiebel Laurence J 
Published: March 2015

ABSTRACTA comparative transcriptomic study of mosquito olfactory tissues recently published inBMC Genomics(Hodges et al, 2014) reported several novel findings that have broad implications for the field of insect olfaction. In this brief commentary, we outline why the conclusions of Hodges et al. are problematic under the current models of insect olfaction and then contrast their findings with those of other RNAseq based studies of mosquito olfactory tissues. We also generated a new RNAseq data set from the maxillary palp ofAnopheles gambiaein an effort to replicate the novel results of Hodges et al. but were unable to reproduce their results. Instead, our new RNAseq data support the more straightforward explanation that the novel findings of Hodges et al. were a consequence of contamination by antennal RNA. In summary, we find strong evidence to suggest that the conclusions of Hodges et al were spurious, and that at least some of their RNAseq data sets were irrevocably compromised by cross-contamination between samples.
Exploring the effects of high concentration of glucose on soil microbial community: An experimental study using the soil of North Bangalore
Authors: Swain Anshuman 
Published: March 2015

AbstractSubstrate Induced Respiration (SIR) is a standard method to study microbial biomass in soil. It is observed that the soil microbial CO2respiration goes up with the glucose concentration till a certain concentration, and afterwards decreases and stabilizes. There are two possible mechanisms via which this can happen: increased osmotic pressure can kill off a group of microbial population or the Crabtree effect takes over the population. An experiment was designed using the SIR; to find the reason for the same and prove or disprove one of these hypothesises.
Repellent compound with larger protective zone than DEET identified through activity-screening ofIr40aneurons, does not requireOrfunction
Authors: Guda Tom , Kain Pinky , Sharma Kavita , Pham Christine Krause , Ray Anandasankar 
Published: March 2015

AbstractThe widely used insect repellent DEET has a limited spatial zone of protection, requiring it to be applied over all exposed areas of skin. Identification of insect DEET-sensing neurons expressing a highly conservedIonotropic receptor,Ir40a, provides an opportunity to identify new structural classes of volatile agonists as potential spatial repellents. By imaging the activity of theIr40a+neurons inD. melanogasterexpressing the calcium sensitive GCaMP3 protein, we identify a strong agonist, 4-methylpiperidine, with a much higher vapor pressure than DEET. Behavioral testing reveals that 4-methylpiperidine repelsAedes aegypti, which is consistent with our model thatIr40amarks a conserved innate aversive pathway. Using a spatial repellency assay we demonstrate that 4-methylpiperidine applied to one part of the hand repels mosquitoes on another part effectively, whereas DEET cannot do so. UsingorcomutantA. aegyptiwe demonstrate that avoidance to 4- methypiperidine is not dependent onOrfamily function. Additional testing oforcomutant mosquitoes demonstrates that they are also effectively repelled by DEET, without coming in contact with it, in heat attraction assays. Together, these results support our initial observations that the conservedIrpathway plays a key role in olfactory repellency and can be used to identify new classes of repellents.
Application of AV-ERP system for on-site project monitoring
Authors: Vegad Kunal , Madurwar Mangesh , Ralegaonkar Rahul 
Published: March 2015

Purpose
– The purpose of this paper is to report the results of a techno-economic feasibility study on the application of Audio Visual Enterprise Resource Planning (AV-ERP). Due to rapid urbanisation and economic growth in developing countries (DCs) like India, there has been tremendous development in infrastructural projects. To maintain the quality and competitive commercial pricing of the projects, stakeholders are working together from different geographic locations. Due to lack of culture in adopting the technological advancements, the on-site construction activities lack coordination among the stakeholders.

Design/methodology/approach
– In the present case, it is observed that the site and various stakeholders like consultants are physically monitoring and controlling the ongoing construction activity from different geographic locations. To manage the effective communication and information exchanges, an integrated tool for surveillance and AV-ERP is proposed in the present paper. These equipment and technologies play a very vital role in the construction industry, which, in turn, significantly affects the progress, cost and time of the project. The techno-economic feasibility of proposed AV-ERP system was evaluated for the ongoing township project over the study area.

Findings
– For the considered case study, 75 per cent cost of the project overhead incurred for site monitoring can be saved by implementing the proposed technology of AV-ERP system.

Practical implications
– The proposed AV-ERP system is a techno-economically viable solution for the effective project management.

Originality/value
– In the DCs like India, to develop the culture for adopting the technological advancements (AV-ERP system) for monitoring the on-site construction activities, the presented case becomes an innovative solution for upcoming medium as well as large-scale construction projects.
User-centred design for collaborative 4D modelling
Authors: Zhou Wei , Heesom David , Georgakis Panagiotis , H.M. Tah Joseph 
Published: March 2015

Purpose
– The purpose of this paper is to clarify the CSCW in collaborative 4D modelling and its user interface (UI)/interaction designs for prototyping. Four-dimensional (4D) modelling technology has potentials to integrate geographically dispersed planners to achieve collaborative construction planning. However, applying this technology in teamwork remains a challenge in computer-supported collaborative work (CSCW).

Design/methodology/approach
– The research adopted user-centred design (UCD) methodology to investigate a usable 4D collaboration prototype through analysis, design and usability testing. By applying CSCW theories, it first clarified the meaning of 4D CSCW to formulate design propositions as design target. By leveraging UCD theories, subsequently, the first-stage research sought an optimal standalone 4D modelling prototype following a parallel design approach. At the second stage, it further investigated into a collaborative 4D modelling prototype using an iterative design. It adopted collaborative task analysis into the UI/interaction design extension for a collaborative prototype based on results obtained from the first stage. The final usability testing was performed on the collaborative prototype to evaluate the designed CSCW and UI in a controlled geographically dispersed teamwork situation.

Findings
– The test results and user feedback verified their usability. It also disclosed design weaknesses in collaborators’ awareness and smooth tasks’ transitions for further enhancement.

Originality/value
– The combination of CSCW and UCD theories is practical for designing collaborative 4D modelling. It can also benefit designs for collaborative modelling in other dimensions like cost analysis, sustainable design, facility management, etc. in building information modelling.
An enabling BIM block library: an online repository to facilitate social inclusion in Australia
Authors: Bridge Catherine , Carnemolla Phillippa 
Published: March 2015

Purpose
– The purpose of this paper is to explore the implications of socially inclusive Building Information Modelling (BIM) library components. BIM requires and integrates many sets of predefined blocks or collection of attributes. Any one of the individual blocks can be replicated and/or stored in a block library for later reuse. However, few if any current block libraries contain or have access to the blocks that enable social inclusion.

Design/methodology/approach
– An action-based research methodology was used to design, develop and deploy three enabling blocks as part of a plan to develop a larger library of tools for BIM practitioners. The Enabling Block Library is an open access library of Australian code-compliant mobility elements published online. This paper discusses the design and development of the library components in detail, explaining how each of the three blocks was selected in our pilot evaluation and how each was identified; fact-checked; planned (designed); deployed (action); and then evaluated.

Findings
– The process and evaluation highlights that appropriate code-compliant design tools can support greater social inclusion aspects of a built environment project. These are tools that are relevant to the full spectrum of industry users of BIM, including designers, engineers and certifiers.

Research limitations/implications
– Because this paper documents the project while in an early launch phase, with a small number of launch blocks, the research results were limited in their ability to thoroughly measure industry or educational impact. However, the results showed how a socially inclusive BIM block library can be developed and why this is important, with literature supporting the potential of its dissemination to the design and construction industry.

Originality/value
– The paper applied action-based research methodology in the development, deployment and evaluation of exploratory BIM use to create more socially inclusive environments. It is of value because it facilitates designers creating the optimum of performance-based accessible environments, rather than the minimum “deemed to satisfy” Building Codes.
Implementing innovation: a stakeholder competency-based approach for BIM
Authors: Murphy M.E. 
Published: March 2015

Purpose– The purpose of the paper was twofold: to review established literature to define and classify BIM; and to identify gaps in current BIM literature with respect to stakeholder competency. Construction projects adopt innovation to address client requirements. Building information modelling (BIM) has been cited as one such innovation. However there is concern that the industry lacks the mechanisms to effectively implement BIM. It is proposed that the problem lies in that BIM is currently being delivered as a project rather than an innovation; and the failure to address stakeholder competency as the key delivery agent of BIM.Design/methodology/approach– A qualitative study using literature and gap analysis techniques was undertaken to establish the “state of the art”. Using an established Competency Framework 31, studies on BIM were assessed. A matrix was developed aligning the BIM studies with the Competency Framework and the findings systematically evaluated to identify gaps in the current literature.Findings– BIM was defined as a technical innovation and classified as a “System” of multiple innovations. Aligning the literature identified that BIM literature has largely focussed on strategic competence with some evidence of technical competence. However, there was scant investigation of information and communication competence which ranks as the most critical competency for BIM implementation. The study identified that whilst the competency-related literature on BIM was not yet rich enough to provide a sound conceptual foundation for investigation, it was evident that BIM implementation aligns closely with the innovation process.Practical implications– The findings highlighted the imperative of developing a competency-based approach for BIM implementation.Social implications– It was anticipated that a competency-based approach will provide insights to benefit construction industry clients and inform the targeted training of project stakeholders.Originality/value– BIM must be implemented as an innovation using a competency-based management approach as the key delivery mechanism.
Preliminary building information modelling adoption model in Malaysia
Authors: Imoudu Enegbuma Wallace , Godwin Aliagha Uche , Nita Ali Kherun 
Published: March 2015

Purpose– This paper aims to investigate the relationship between building information modelling (BIM) adoption from the perspectives of people, process and technology to strategic information technology (IT) in construction mediated by collaborative processes for new BIM entrants. The demand pull for more effective project delivery in the construction industry across the globe has continued to transform design techniques from two-dimensional, three-dimensional (3D) and, currently, BIM. Leverage on IT is pivotal for construction industry development as earmarked by the Malaysian construction industry master plan. BIM uptake by stakeholders in Malaysia construction industry is on a gradual increase. BIM generates and manages building data during its life cycle via 3D, real-time, dynamic building modelling.Design/methodology/approach– BIM model is dependent on collaborative contribution by project teams’ input at various stages. However, challenges such as people, process and technology impede an effective adoption rate in Malaysia. This paper presents a continuation of an ongoing theoretical framework developed, to further investigate the relationship between BIM adoption from perspectives of people, process and technology to strategic IT in construction and collaborative process. To develop the framework, an extensive literature review on factors affecting BIM adoption was carried out. The underlining gap stems from a positivist standpoint in examining human – IT interaction. The model builds on conceptual technology acceptance models incorporating strategic IT implementation and collaborative processes in the industry.Findings– The paper examined factors affecting BIM adoption in Malaysia. The factors are further affected by the environment where BIM is utilised. The paper also presents the mediating effect of collaboration for new BIM entrants. Overall, the theorised hypotheses delineate the strength and significance of the examined relationship within the model. Subsequently, the data will be collected from construction industry professionals (architects, quantity surveyors, engineers and contractors) through the developed survey instrument. The hypotheses will undergo structural equation modelling to analyse the desired statistical power, test for close versus exact fit and complexity of the model.Social implications– The findings will delineate the variables with predominant impact on BIM adoption and serves as a guide to future policymaking on BIM implementation in Malaysia.Originality/value– Current research on BIM in Malaysia is limited to readiness and awareness. This paper extends the need for empirical findings from construction professionals’ perception of BIM. The findings also explain reasons for BIM adoption in new BIM entrants and add to current body of knowledge on IT acceptance model formation.
Learning and behaviour: addressing the culture change conundrum: part one
Authors: Coulson-Thomas Colin Joseph 
Published: March 2015

Purpose
– Calls for culture change often result from a desire to change certain behaviours. The purpose of this paper is to summarise some key findings of a five-year investigation into quicker and more affordable routes to creating high-performance organisations. It suggests a practical and cost-effective way of quickly changing the behaviour of key work-groups independently of corporate culture which integrates working and learning and simultaneously achieves multiple corporate objectives.

Design/methodology/approach
– A programme of critical success factor, “issue” and other surveys was complemented with a five-year evaluation of more recent case studies to understand early adoptions of performance support and to assess their results and implications. The applications examined were discussed with the relevant technical architect and the results obtained corroborated with commissioner/user performance data and/or documented assessments/reactions.

Findings
– The use of performance support which can integrate learning and working represents an affordable way of changing the behaviour of particular and front-line work-groups independently of corporate culture. Changing a culture defined in terms of deeply held attitudes, values and beliefs is problematic, but required changes of behaviour can often be quickly accomplished using performance support, which can also address particular problems and deliver benefits for multiple stakeholders.

Practical implications
– Culture change is neither necessary nor desirable where there are quicker, practical and affordable ways of altering behaviours while organisational cultures remain unchanged. It might also be problematic in organisations that need to embrace a diversity of cultures and encourage a variety of approaches and behaviours across different functions and business units. One can avoid certain general, expensive, time consuming and disruptive corporate programmes in an area such as culture change and adopt a quick, focused and cost-effective alternative that can quickly deliver multiple benefits for people and organisations.

Originality/value
– This paper summarises the main findings of an investigation that has identified deficiencies of contemporary responses to a requirement to change certain behaviours that involve seeking to change a corporate culture and questions their practicality, desirability, time-scale and affordability. It presents and evidence-based alternative approach that is more affordable and can more quickly deliver changes of behaviour required and ensure compliance with relevant laws, regulations, policies and codes.