bluuebunny/crossref_metadata_2025_split huggingface dataset:
Voltammetric Determination of Folic Acid Using Adsorption of Methylene Blue onto Electrodeposited of Reduced Graphene Oxide Film Modified Glassy Carbon Electrode
Authors: Zhang Dongdong , Ouyang Xiaoyan , Ma Weina , Li Lingzhi , Zhang Yanmin 
Published: July 2015

AbstractThis work presents a sensitive voltammetric method for determination of folic acid by adsorbing methylene blue onto electrodeposited reduced graphene oxide film modified glassy carbon electrode (MB/ERGO/GCE) in 100 mM KCl‐10 mM sodium phosphate buffer solution (pH 7.40). The surface morphology of the MB/ERGO/GCE modified electrode was characterized using scanning electron microscopy, displays that both MB and ERGO distributed homogeneously on the surface of GCE. The MB/ERGO/GCE modified electrode shows more favorable electron transfer kinetics for potassium ferricyanide and potassium ferrocyanide probe molecules, which are important electroactive compounds, compared with bare GCE, MB/GCE, and ERGO/GCE. The electrochemical behaviors of folic acid at MB/ERGO/GCE were investigated by cyclic voltammetry, suggesting that the modified electrode exhibited excellent electrocatalytic activity towards folic acid compared with other electrodes. Under physiological condition, the MB/ERGO/GCE modified electrode showed a linear voltammetric response from 4.0 μM to 167 μM for folic acid, and with the detection limit of 0.5 μM (S/N=3). The stability, reproducibility and anti‐interference ability of the modified electrode were examined. The developed method has been successfully applied to determination of FA in tablets with a satisfactory recovery from 96 % to 100 %. The work demonstrated that the electroactive MB adsorbing onto graphene modified electrode showed an enhanced electron transfer property and a high resolution capacity to FA.
The Influence of Different Carbon Sources on Li3V2(PO4)3/C Synthesized by a Hybrid Sol–Gel Method as Cathode for Lithium‐Ion Batteries
Authors: Li Lingfang , Fan Changling , Huang Xiaobing , Zhang Xiang , Han Shaochang 
Published: July 2015

AbstractUsing cetyltrimethyl ammonium bromide (CTAB) as the surfactant, here we present the synthesis of lithium vanadium phosphate (LVP) Li3V2(PO4)/C by using a hybrid sol–gel method. Glucose, phenolic resin, and polyvinylidene fluoride (PVDF) are respectively used as the carbon sources for the three final products, LVP@GC, LVP@PR, LVP@PF. In addition, pure Li3V2(PO4), which is marked as LVP@0, was synthesized under the same conditions for comparison. The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) results indicate that LVP@PR and LVP@PF have particle sizes less than 0.5 μm. Li‐cycling studies are preformed in half‐cell over the potential range of 3.0–3.4 V. All four samples exhibited outstanding cycle performance, but the rate performances of LVP@0 and LVP@GC are worse than the other two. LVP@0 only delivers a discharge capacity of 40 mAh g−1 and LVP@GC delivers 70 mAh g−1 at 15 C [Li3V2(PO4) theoretical capacity=132 mAh g−1 over 3.0–3.4 V). LVP@PR and LVP@PF showed impressive electrochemical performance. LVP@PF delivered a near‐theoretical capacity at ≤2 C rate. At rates of 10 C and 15 C, the capacities of LVP@PR and LVP@PF are both above 90 mAh g−1 and LVP@PF is slightly higher than LVP@PR.
Stability of the time‐domain analysis method including a frequency‐dependent soil–foundation system
Authors: Duarte Laudon Alex , Kwon Oh‐Sung , Ghaemmaghami Amir Reza 
Published: July 2015

SummaryA number of methods have been proposed that utilize the time‐domain transformations of frequency‐dependent dynamic impedance functions to perform a time‐history analysis. Though these methods have been available in literature for a number of years, the methods exhibit stability issues depending on how the model parameters are calibrated. In this study, a novel method is proposed with which the stability of a numerical integration scheme combined with time‐domain representation of a frequency‐dependent dynamic impedance function can be evaluated. The method is verified with three independent recursive parameter models. The proposed method is expected to be a useful tool in evaluating the potential stability issue of a time‐domain analysis before running a full‐fledged nonlinear time‐domain analysis of a soil–structure system in which the dynamic impedance of a soil–foundation system is represented with a recursive parameter model. Copyright © 2015 John Wiley & Sons, Ltd.
Low concentrations of dihydrotestosterone induce female-to-male sex reversal in the frog Pelophylax nigromaculatus
Authors: Xu Wei , Li Yuan-Yuan , Lou Qin-Qin , Chen Xiao-Ran , Qin Zhan-Fen , Wie Wu-Ji 
Published: July 2015

Abstract

Previous studies have demonstrated that some amphibian species can be sex-reversed by high concentrations of androgens. Little attention has focused on the effects of androgenic endocrine-disrupting chemicals (EDCs) on amphibians. The present study aimed to investigate the effects of lower concentrations of the androgenic EDC 5α-dihydrotestosterone (DHT) on gonadal differentiation and development in Pelophylax nigromaculatus, a true frog distributed widely in East Asia. Tadpoles at Gosner stage 24/25 were exposed to nominal concentrations of 40 ng/L, 400 ng/L, and 4000 ng/L DHT to complete metamorphosis. In all DHT treatment groups, males and ambiguous sexes were identified based on gonadal morphology, whereas no females were found; thus, all treatment groups exhibited male-skewed ratios compared with the control group. Gonadal histological examination revealed that ambiguous sexes displayed overall testicular structure with certain ovarian characteristics, demonstrating that DHT-induced sex-ambiguous gonads were incomplete ovary-to-testis reversals (IOTTRs). The expression levels of some ovary-biased genes in the IOTTRs were significantly higher than in the control testes but lower than in the control ovaries. These results show that low concentrations of DHT induced complete or incomplete female-to-male sex reversal in P. nigromaculatus, and incomplete sex reversal retained certain ovarian characteristics not only at gonadal morphological and histological levels but also at the molecular level. They present study highlights potential risks of DHT and other androgenic EDCs for P. nigromaculatus. Environ Toxicol Chem 2015;34:2370–2377. © 2015 SETAC
Agents collaboration‐based service provisioning strategy for large enterprise business in hybrid cloud
Authors: Chunlin Li , Xin Yan , LaYuan Li 
Published: July 2015

AbstractThe paper proposes agent collaboration‐based service provisioning strategy for large enterprise business in hybrid cloud environment. The proposed service provisioning model is constructed by the agents, which include hybrid cloud user agent, hybrid cloud service agent and hybrid cloud provider agent. Hybrid cloud user agents adjust needed service according to the prices of hybrid cloud services. Hybrid cloud service agents compete actively for the requests from hybrid cloud user agents and execute them for gaining profits. Hybrid cloud service agents dynamically change cloud services' prices and send updated prices to all hybrid cloud user agents. Hybrid cloud services' prices are adjusted to accommodate the service demands from hybrid cloud user agents. Hybrid cloud provider agent tries to maximise its profit based on its resource capability and energy consumption. The paper also presents an agent collaboration‐based service provisioning algorithm. The simulations are designed to compare the performance of the proposed algorithm with the other related works. Copyright © 2015 John Wiley & Sons, Ltd.
Controlled release of an anthrax toxin‐neutralizing antibody from hydrolytically degradable polyethylene glycol hydrogels
Authors: Liang Yingkai , Coffin Megan V. , Manceva Slobodanka D. , Chichester Jessica A. , Jones R. Mark , Kiick Kristi L. 
Published: July 2015

AbstractIn this study, hydrophilic and hydrolytically degradable poly (ethylene glycol) (PEG) hydrogels were formed via Michael‐type addition and employed for sustained delivery of a monoclonal antibody against the protective antigen of anthrax. Taking advantage of the PEG‐induced precipitation of the antibody, burst release from the matrix was avoided. These hydrogels were able to release active antibodies in a controlled manner from 14 days to as long as 56 days in vitro by varying the polymer architectures and molecular weights of the precursors. Analysis of the secondary and tertiary structure and the in vitro activity of the released antibody showed that the encapsulation and release did not affect the protein conformation or functionality. The results suggest the promise for developing PEG‐based carriers for sustained release of therapeutic antibodies against toxins in various applications. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 113–123, 2016.
Magnesium Halide‐promoted Ring‐opening Reaction of Cyclic Ether in the Presence of Phosphine Halide
Authors: Chang Yu‐Chang , Weng Chia‐Ming , Shaikh Tanveer M. , Hong Fung‐E 
Published: July 2015

AbstractA new route to the direct preparation of H‐phosphinate esters has been explored. The ring‐opening reaction of cyclic ether (tetrahydrofuran or tetrahydropyrane) was carried out with magnesium halide in the presence of phosphine halide (PRCl2 or PCl3). The process is straightforward and all the reagents are relatively cheap and readily available. Magnesium halide‐mediated THF ring‐opening (SN2@C) and the subsequent SN2@P elementary reactions that giving rise to the intermediate of haloalkyl phosphinates have been discussed based on our experimental findings (Path I: SN2@C−+SN2@P). Another possible route, the direct SN2 between THF (nucleophile) and phosphine halide (electrophile) that followed by THF ring opening by halide dissociated from phosphine halide (Path II: SN2@P−+SN2@C), was also proposed. However, path II is the least likely reaction path because neutral THF is not a good nucleophile. H‐phosphinate esters could be readily available in the subsequent hydrolysis process. Considering the ionic bond strength in magnesium halides and the nucleophilicity of halides dissociated from MgX2 in protic solvents like water, MgBr2 is recommended for ring‐opening reactions of cyclic ethers.
Mannose‐Binding Lectin and Diabetic Nephropathy in Type 1 Diabetes
Authors: Zhao Shi‐qi , Hu Zhao 
Published: July 2015

ObjectiveThe aim of this study was to investigate serum levels of mannose‐binding lectin (MBL) in type 1 diabetes with diabetic nephropathy (DN) and persistent normoalbuminuria (PN).MethodSerum MBL levels were determined in 224 type 1 diabetes with overt nephropathy and 224 type 1 diabetes with PN matched for sex, age, and duration of diabetes The prediction value of MBL was compared with hemoglobin A1c (HbA1c), high‐sensitivity C‐reactive protein (Hs‐CRP) and other known predictors. Multivariate analyses were performed using logistic regression models.ResultsThe serum MBL levels were significantly higher in diabetes with DN as compared to with PN (P < 0.0001). Based on the receiver operating characteristic (ROC) curve, the optimal cutoff value of serum MBL levels as an indicator for diagnosis of DN was projected to be 1,680 μg/l, which yielded a sensitivity of 75.4% and a specificity of 78.8%, with the area under the curve at 0.768 (95% confidence interval [CI], 0.724–0.815). Multivariate logistic regression analysis adjusted for common factors showed that serum MBL level ≥ 1,680 μg/l was an independent indictor of DN (odds ratio [OR] = 6.99; 95% CI: 2.83–17.15).ConclusionIn type 1 diabetic patient, evaluated serum levels of MBL can be seen as an independent marker of DN even after correcting for possible confounding factors.
Biomimetic phantom for cardiac diffusion MRI
Authors: Teh Irvin , Zhou Feng‐Lei , Hubbard Cristinacce Penny L. , Parker Geoffrey J.M. , Schneider Jürgen E. 
Published: July 2015

PurposeDiffusion magnetic resonance imaging (MRI) is increasingly used to characterize cardiac tissue microstructure, necessitating the use of physiologically relevant phantoms for methods development. Existing phantoms are generally simplistic and mostly simulate diffusion in the brain. Thus, there is a need for phantoms mimicking diffusion in cardiac tissue.Materials and MethodsA biomimetic phantom composed of hollow microfibers generated using co‐electrospinning was developed to mimic myocardial diffusion properties and fiber and sheet orientations. Diffusion tensor imaging was carried out at monthly intervals over 4 months at 9.4T. 3D fiber tracking was performed using the phantom and compared with fiber tracking in an ex vivo rat heart.ResultsThe mean apparent diffusion coefficient and fractional anisotropy of the phantom remained stable over the 4‐month period, with mean values of 7.53 ± 0.16 × 10‐4 mm2/s and 0.388 ± 0.007, respectively. Fiber tracking of the 1st and 3rd eigenvectors generated analogous results to the fiber and sheet‐normal direction respectively, found in the left ventricular myocardium.ConclusionA biomimetic phantom simulating diffusion in the heart was designed and built. This could aid development and validation of novel diffusion MRI methods for investigating cardiac microstructure, decrease the number of animals and patients needed for methods development, and improve quality control in longitudinal and multicenter cardiac diffusion MRI studies. J. MAGN. RESON. IMAGING 2016;43:594–600.
Aroma volatiles obtained at harvest by HS‐SPME/GC‐MS and INDEX/MS‐E‐nose fingerprint discriminate climacteric behaviour in melon fruit
Authors: Chaparro‐Torres Libia A , Bueso María C , Fernández‐Trujillo Juan P 
Published: July 2015

AbstractBACKGROUNDMelon aroma volatiles were extracted at harvest from juice of a climacteric near‐isogenic line (NIL) SC3‐5‐1 with two quantitative trait loci (QTLs) introgressed which produced climacteric behaviour and its non‐climacteric parental (PS) using two methodologies of analysis: static headspace solid phase micro‐extraction (HS‐SPME) by gas chromatography–mass spectrometry (GC‐MS) and inside needle dynamic extraction (INDEX) by MS‐based electronic nose (MS‐E‐nose).RESULTSOf the 137 volatiles compounds identified, most were found at significantly higher concentrations in SC3‐5‐1 than in PS in both seasons. These volatiles were mostly esters, alcohols, sulfur‐derived esters and even some aldehydes and others. The number of variables with high correlation values was reduced by using correlation network analysis. Partial least squares‐discriminant analysis (PLS‐DA) achieved the correct classification of PS and SC3‐5‐1. The ions m/z 74, 91, 104, 105, 106 and 108, mainly volatile derivatives precursor phenylalanine, were the most discriminant in SC3‐5‐1 and PS. As many as 104 QTLs were mapped in season 1 and at least 78 QTLs in each season with an effect above the PS mean.CONCLUSIONGC‐MS gave better discrimination than E‐nose. Most of the QTLs that mapped in both seasons enhanced aroma volatiles associated with climacteric behaviour. © 2015 Society of Chemical Industry
Heuristic approach to selecting a color appearance model for hue‐preserved wide‐color gamut mapping
Authors: Masaoka Kenichiro , Yamashita Takayuki , Nishida Yukihiro , Sugawara Masayuki 
Published: July 2015

AbstractWith the advent of wide‐gamut system colorimetry for ultra‐high definition television, the development of a gamut mapping algorithm for wide to standard gamuts is greatly needed. Most gamut mapping techniques have been developed to retain the perceived hues of the source as predicted by a color appearance model. However, some color appearance models erroneously predict the saturated colors, generating a serious hue discontinuity in wide‐color gamut mapping onto the Rec. 709 gamut boundary. This paper presents a heuristic approach to determining whether a color appearance model may create such artifacts when used in hue‐preserved gamut mapping algorithms.
Pediatric endoscopic ear surgery in clinical practice: Lessons learned and early outcomes
Authors: Cohen Michael S. , Landegger Lukas D. , Kozin Elliott D. , Lee Daniel J. 
Published: July 2015

Objectives/HypothesisOnly a few reports describe the outcomes following endoscopic ear surgery (EES) in children for chronic ear disease. We differentiate between transcanal endoscopic ear surgery (TEES), where the case is performed with only endoscopic visualization, from non‐TEES, where the endoscope is not used at all or used as an adjunct to the microscope. We hypothesize that EES is an effective approach to manage middle ear pathology using a transcanal approach in most cases, and can be incorporated into a pediatric otology practice with a neutral or positive effect on outcomes. Lessons learned during this process are analyzed and discussed.Study DesignSingle‐institution, retrospective chart review of outcomes following TEES and non‐TEES in children from January 1, 2013 through July 1, 2014.MethodsProcedures included tympanoplasty, ossiculoplasty, and cholesteatoma resection. Primary outcome measures included closure rate of tympanic membrane perforations, audiometric outcomes, and complications. Surgical times were reported as secondary measures.ResultsNinety‐four patients underwent 121 middle ear procedures. TEES was performed in 51/121 of cases (42.1%). Comparison of TEES versus non‐TEES cases showed no significant difference in rate of tympanoplasty closure (P > .99). The mean pure‐tone improvement following TEES tympanoplasty was −7.8 dB versus −1.33 dB for non‐TEES cases (P = .03). Surgical times were similar between groups.ConclusionsEES techniques were readily incorporated into a pediatric otology practice. A standardized EES classification system is useful for analyzing utilization patterns and results across institutions. Tympanic membrane closure rates and hearing outcomes were similar in TEES and non‐TEES cases.Level of Evidence4. Laryngoscope, 126:732–738, 2016
Sinonasal malignancies: A population‐based analysis of site‐specific incidence and survival
Authors: Dutta Rahul , Dubal Pariket M. , Svider Peter F. , Liu James K. , Baredes Soly , Eloy Jean Anderson 
Published: July 2015

Objectives/HypothesisSinonasal malignancies vary in behavior according to histology and anatomical location. Incidence, survival, and optimal treatment for these lesions are thus uncertain in various cases. Our objective was to utilize a national population‐based registry to identify the most common sinonasal histopathologies by anatomical site, and subsequently analyze the data by incidence trends, survival rates, patient demographics, and treatment modalities.Study DesignRetrospective analysis of the United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry.MethodsThe SEER database was examined for patients diagnosed with sinonasal malignancies between 1973 and 2011. Data were stratified according to anatomical site, incidence, survival, histology, staging, and patient demographics. Therapy‐based outcomes were analyzed for cases from 1983 to 2011.ResultsA total of 13,295 patients were identified, with an incidence of 0.83 per 100,000 people. Males comprised 58.6% of cases. Whites represented 81.5% of cases, while blacks comprised 8.7%. Squamous cell carcinoma was the most common histology (41.9%) across all sites of the sinonasal tract. The most common anatomical site of malignancy was the nasal cavity (45.7%), and least common was the frontal sinus (1.2%). For single sites, 5‐year disease‐specific survival (DSS) was highest for nasal cavity tumors (67.1%) and lowest for overlapping sinus malignancies (37.6%). The overall 5‐year DSS for all sinonasal malignancies was 53.7%.ConclusionSinonasal malignancies are rare entities with poor overall prognosis. By anatomical site, prognosis is best for nasal cavity cancers and worst for overlapping lesions.Level of Evidence4. Laryngoscope, 125:2491–2497, 2015
Retropharyngeal lymph node involvement in human papillomavirus–associated oropharyngeal squamous cell carcinoma
Authors: Baxter Michael , Chan Jason Y. K. , Mydlarz Wojciech K. , Labruzzo Salvatore V. , Kiess Ana , Ha Patrick K. , Nafi Aygun , Nishant Agrawal 
Published: July 2015

Objectives/HypothesisThe purpose of this study was to retrospectively review patients with human papillomavirus (HPV)–associated oropharyngeal squamous cell carcinoma (OPSCC) for the presence of retropharyngeal lymph nodes (RPLNs) prior to treatment using positron emission tomography/computed tomography (PET/CT), and to determine if the presence of RPLNs is of utility in predicting outcomes.Study DesignRetrospective review of patient data from a single institution.MethodsTwo hundred thirty patients with a diagnosis of HPV‐associated OPSCC were identified from 2002 to 2013. The presence of RPLNs was determined primarily from findings on PET/CT as reviewed in a standardized fashion by two neuroradiologists.ResultsOf the 230 patients, 165 had pretreatment PET/CT imaging available for review. There were a total of 16 patients (9.70%) with evidence of RPLNs. Among patients positive for RPLNs pretreatment, with an average follow‐up of 2 years, there was a 5.2‐times greater odds of having recurrence or death (31.3% vs. 8.1%, P = .004). When T and N stage were adjusted for with multiple regression, there was no significant association between RPLN status and recurrence free survival.ConclusionsThis is a unique investigation utilizing PET/CT to classify RPLN status in HPV‐associated OPSCC. RPLNs were relatively common in our HPV‐associated OPSCC cohort at 9.70%, at the low end of the quoted positivity of 10% to 27% in all OPSCC. A combination of PET/CT is useful in identifying RPLNs. Prospective investigation will be needed to determine the sensitivity and specificity of PET/CT in identifying RPLNs, and the precise impact of RPLNs on HPV‐associated OPSCC treatment and outcomes.Level of Evidence4. Laryngoscope, 125:2503–2508, 2015
Normative data for rotational chair stratified by age
Authors: Chan Fung M. , Galatioto Jessica , Amato Michael , Kim Ana H. 
Published: July 2015

Objectives/HypothesisThe purpose of this study is to examine the range of vestibulo‐ocular reflex (VOR) gain on rotary chair (RC) testing in subjects without ear and vestibular problems stratified by age and gender.Study DesignProspective cross‐sectional study.MethodsOne hundred subjects ranging in age from 6 to 78 years underwent RC testing. VOR gains at frequencies ranging from 0.01 to 0.64 Hz were recorded. The PROC MIXED procedure in SAS was used to analyze differences in VOR gain between gender and the following age groups: group 1 (6–12 years), group 2 (13–17 years), group 3 (18–30 years), group 4 (31–50 years), and group 5 (>50 years).ResultsTwenty subjects were recruited for each of the five groups. Group 1 showed the highest average VOR gain compared to all other age groups (P < .05). There was an inverse correlation between VOR gain and age (P < .05). The lowest frequency (0.01 Hz) had the highest correlation between VOR gain and age (r = −0.425; P < .0001).ConclusionsOur study demonstrates VOR gain differences with age, especially in the preadolescent and geriatric groups. The current manufacturer‐provided normative data do not serve as an accurate reference, especially for these two age groups. A larger population of all age groups should be compared to the current RC manufacturer normative values to ensure that they accurately reflect the true normative data.Level of Evidence2. Laryngoscope, 126:460–463, 2016