bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Satellite Quantitative Precipitation Estimation Using GOES-Retrieved Cloud Optical Depth
Authors: Stenz Ronald , Dong Xiquan , Xi Baike , Feng Zhe , Kuligowski Robert J. 
Published: October 2015

Abstract
To address gaps in ground-based radar coverage and rain gauge networks in the United States, geostationary satellite quantitative precipitation estimation (QPE) such as the Self-Calibrating Multivariate Precipitation Retrieval (SCaMPR) can be used to fill in both spatial and temporal gaps of ground-based measurements. Additionally, with the launch of Geostationary Operational Environmental Satellite R series (GOES-R), the temporal resolution of satellite QPEs may be comparable to Weather Surveillance Radar-1988 Doppler (WSR-88D) volume scans as GOES images will be available every 5 min. However, while satellite QPEs have strengths in spatial coverage and temporal resolution, they face limitations, particularly during convective events. Deep convective systems (DCSs) have large cloud shields with similar brightness temperatures (BTs) over nearly the entire system, but widely varying precipitation rates beneath these clouds. Geostationary satellite QPEs relying on the indirect relationship between BTs and precipitation rates often suffer from large errors because anvil regions (little or no precipitation) cannot be distinguished from rain cores (heavy precipitation) using only BTs. However, a combination of BTs and optical depth τ has been found to reduce overestimates of precipitation in anvil regions. A new rain mask algorithm incorporating both τ and BTs has been developed, and its application to the existing SCaMPR algorithm was evaluated. The performance of the modified SCaMPR was evaluated using traditional skill scores and a more detailed analysis of performance in individual DCS components by utilizing the Feng et al. classification algorithm. SCaMPR estimates with the new rain mask benefited from significantly reduced overestimates of precipitation in anvil regions and overall improvements in skill scores.
Perianchor Cyst Formation Around Biocomposite Biodegradable Suture Anchors After Rotator Cuff Repair
Authors: Kim Sae Hoon , Kim Do Yeon , Kwon Ji Eun , Park Ji Soon , Oh Joo Han 
Published: October 2015

Background: Biodegradable anchors may lead to perianchor cyst formation or osteolysis. A new generation of anchors containing osteoconductive material was recently presented, but there is currently no solid evidence that this concept decreases cyst formation around anchors. Hypothesis: The null hypothesis was that the prevalence and severity of cyst formation around anchors would be similar for all 3 anchor types. Study Design: Cohort study; Level of evidence, 2. Methods: To evaluate differences between anchor behaviors postoperatively, this study included 2 groups of patients who underwent rotator cuff repair. In group 1 (n = 38), transosseous-equivalent rotator cuff repair was performed in all patients. At the time of repair, 2 different anchors (anchor A: 23% microstructured β-tricalcium phosphate plus 77% polylactic acid enantiomers [PLLA]; and anchor B: 30% hydroxyapatite plus 70% PLLA) were used for medial-row repair. Insertion locations (anterior or posterior) were randomly assigned. In group 2 (n = 38), the same procedure was performed; however, 1 of the anchors used in group 1 was changed (anchor A: as above; and anchor C: 30% β-tricalcium phosphate plus 70% faster absorbing polylactic-co-glycolic acid copolymer [85% PLLA plus 15% polyglycolic acid]). The presence and severity of fluid collection around the anchors was evaluated by magnetic resonance imaging at approximately 1 year after rotator cuff repair (12.7 ± 0.9 months for group 1 and 12.6 ± 1.8 months for group 2). Results: In group 1, a fluid signal was observed in 14 patients (36.8%) for anchor A and in 12 patients (31.6%) for anchor B ( P > .05). The severity of perianchor cyst formation was no different for the 2 anchors (respective fluid signal grades [0-4]: 24, 3, 9, 1, and 1 for anchor A; and 26, 4, 7, 1, and 0 for anchor B; P > .05). However, in group 2, cysts were observed in 19 patients (50%) for anchor A and in 3 patients (7.9%) for anchor C ( P < .001). For anchor C, only 2 cases of grade 1 and 1 case of grade 2 fluid collection were observed. Intergroup analysis of anchor A revealed no significant differences in the prevalence or severity of perianchor cyst formation ( P > .05). Healing failure was observed in 12 patients (31.6%) in group 1 and 10 patients (26.3%) in group 2 ( P > .05). Conclusion: New-generation biodegradable suture anchors seem to decrease the severity of perianchor cyst formation. Future research is required to optimize the compositions and proportions of osteoconductive materials and polymers to improve adverse reactions. Nevertheless, controlling the properties of polymers and adding osteoconductive material both appear to enhance biocompatibility.
Comparison of serum and urine lead levels in opium addicts with healthy control group
Authors: Khatibi-Moghadam H , Khadem-Rezaiyan M , Afshari R 
Published: October 2015

Context: Lead-contaminated opium is one of the new sources of lead exposure in our region. As far as the literature review is concerned, there are limited comparative studies about comparison of blood lead level (BLL) in addict patients with healthy controls. Objective: We aimed to compare BLL and urine lead level (ULL) between opium addicts with the healthy control group. Materials and Methods: Forty opium addict subjects (mean age: 43 ± 10 years) as the patient group and 40 healthy subjects (mean age: 41 ± 9 years) as the control group participated. Three milliliter of whole blood and urine was obtained from both groups and lead level was assessed using atomic absorption spectrophotometry. Results: The mean value of BLL in patient group was 7.14 ± 1.41 mcg/dL and that in the healthy control group was 5.42 ± 1.46 mcg/dL. The mean value of ULL was 2.62 ± 0.83 mcg/dL in the patient group and 2.50 ± 0.76 mcg/dL in the healthy control group. BLL was different in the two groups ( p < 0.001), but ULL was not ( p = 0.5). There was a significant correlation between BLL with duration of opium addiction in the patient group ( r = −0.403, p = 0.01). BLL and ULL were significantly correlated in controls ( r = 0.436, p = 0.005) and not in patients. Discussion and conclusion: It was observed that the BLL in opium addicts was significantly higher than that in the healthy control group. This can be due to use of adulterated opium with lead. Therefore, screening of blood lead concentration is helpful for opium-addict patients especially with nonspecific symptoms.
Efficacy of antiviral chemotherapy for retrovirus-infected cats
Authors: Hartmann Katrin 
Published: October 2015

Global importance: The two feline retroviruses, feline immunodeficiency virus (FIV) and feline leukaemia virus (FeLV), are global and widespread, but differ in their potential to cause disease. Viral infection – FIV: FIV, a lentivirus that shares many properties with human immunodeficiency virus (HIV), can cause an acquired immune deficiency syndrome, which predisposes cats to other infections, stomatitis, neurological disorders and tumours. Although secondary infections are common, specific opportunistic infections or acquired immunodeficiency virus-defining infections, such as those that occur with HIV, are not commonly reported in FIV-infected cats. In most naturally infected cats, FIV does not cause a severe clinical syndrome; with appropriate care, FIV-infected cats can live many years before succumbing to conditions unrelated to their FIV infection. Thus, overall survival time is not necessarily shorter than in uninfected cats, and quality of life is usually high over many years or lifelong. Viral infection – FeLV: FeLV, an oncornavirus, is more pathogenic than FIV. Historically, it was considered to account for more disease-related deaths and clinical syndromes in cats than any other infectious agent. Recently, the prevalence and importance of FeLV have been decreasing, mainly because of testing and eradication programmes and the use of FeLV vaccines. Progressive FeLV infection can cause tumours, bone marrow suppression and immunosuppression, as well as neurological and other disorders, and leads to a decrease in life expectancy. However, with appropriate care, many FeLV-infected cats can also live several years with a good quality of life. Practical relevance: A decision regarding treatment or euthanasia should never be based solely on the presence or absence of a retrovirus infection. Antiviral chemotherapy is of increasing interest in veterinary medicine, but is still not used commonly. Evidence base: This article reviews the current literature on antiviral chemotherapy in retrovirus-infected cats, focusing on drugs that are currently available on the market and, thus, could potentially be used in cats.
Cytauxzoonosis
Authors: Sherrill Meredith K , Cohn Leah A 
Published: October 2015

Practical relevance: Cytauxzoonosis is a life-threatening hematoprotozoal disease with a rapidly progressive clinical course. Once considered a rare disease only relevant to a small geographic area, it is now recognized in more than about a third of the United States. The geographic range seems likely to increase with expansion of the range of the vector tick. Clinical challenges: Both disease diagnosis and treatment offer challenges. The acute illness is often recognized by characteristic parasitic cellular inclusions, but illness may occur before parasites can be identified, and parasitic inclusions may persist long after illness has resolved. Also, while infection was once considered nearly uniformly fatal, subclinical infections are now recognized. Disease prognosis has improved for many cats through implementation of new therapies, but some pathogens are resistant to these therapies and death from disease is still common. Currently, prevention strategies are limited to ectoparasite control. Global importance: Cytauxzoonosis caused by Cytauxzoon felis is limited to the Americas, and is especially problematic in southeastern and south central USA. However, other Cytauxzoon species have been recognized in Europe and Asia. Audience: This review is aimed at veterinary practitioners and focuses on the diagnosis and treatment of cytauxzoonosis. Disease management is of crucial importance in endemic regions. Furthermore, the expanding geographic range of infection, and the possibility of parasite identification in chronically infected cats with a travel history, make understanding cytauxzoonosis relevant in non-endemic regions as well. Evidence base: The authors draw on evidence from prospective clinical trials, experimental infections, retrospective clinical studies and case reports, as well as their own personal experience with the diagnosis and treatment of cytauxzoonosis.
Spinal cord involvement in Behçet’s disease
Authors: Lee Hyung Seok , Kim Do Young , Shin Ha Young , Choi Young-Chul , Kim Seung Min 
Published: October 2015

Background: Spinal cord involvement in Behçet’s disease is not well studied. Objective: To evaluate the clinical, laboratory and magnetic resonance imaging characteristics of spinal cord involvement in Behçet’s disease. Methods: We retrospectively reviewed 10 spinal cord involvements in seven patients with Behçet’s disease. Results: The median age of onset for spinal cord involvement was 32 (23–45 years). Two patients showed a secondary progressive course. Cerebrospinal fluid findings revealed mild to moderate pleocytosis and/or elevated protein levels. In eight spinal cord involvements, the lesion was longer than three vertebrae. Serum anti-aquaporin-4 antibody was negative in all four patients tested. Conclusions: Longitudinally extensive transverse myelitis is a characteristic manifestation of spinal cord involvement in Behçet’s disease.
Utility of diffusion tensor imaging parameters for diagnosis of hemimegalencephaly
Authors: Oikawa Tomomi , Tatewaki Yasuko , Murata Takaki , Kato Yumiko , Mugikura Shunji , Takase Kei , Takahashi Shoki 
Published: October 2015

Background Hemimegalencephaly is a rare hamartomatous entity characterised by enlargement of all or part of the cerebral hemisphere ipsilaterally with cortical dysgenesis, large lateral ventricle and white matter hypertrophy with or without advanced myelination. Although conventional magnetic resonance imaging (MRI) is useful for detecting these diagnostic features, hemimegalencephaly is not always easily distinguished from other entities, especially when hemimegalencephaly shows blurring between the grey and white matter. Diffusion tensor imaging (DTI) is a functional MRI technique commonly used to assess the integrity of white matter. The usefulness of DTI in assessing hemimegalencephaly has not been fully elucidated. In this study, we clarified the characteristics of hemimegalencephaly with regard to DTI and its parameters including fractional anisotropy and apparent diffusion coefficient. Methods Three patients with hemimegalencephaly underwent MRI including DTI. We first visually compared fractional anisotropy mapping and conventional MRI. Next, we quantitatively measured the fractional anisotropy and apparent diffusion coefficient values in the subcortical white matter of the hemisphere with hemimegalencephaly and corresponding normal-appearing contralateral regions and analysed the values using the Mann–Whitney U test. Results On fractional anisotropy mapping, we could clearly distinguish the junction of grey and white matter and observed thicker white matter in the hemisphere with hemimegalencephaly, which was unclear on conventional MRI. The white matter in the hemisphere with hemimegalencephaly showed significantly higher fractional anisotropy ( P < 0.0001) and lower apparent diffusion coefficient ( P = 0.0022) values than the normal contralateral side. Conclusion DTI parameters showed salient hemimegalencephaly features and could be useful in its assessment.
Long-term survival and T-cell kinetics in relapsed/refractory ALL patients who achieved MRD response after blinatumomab treatment
Authors: Zugmaier Gerhard , Gökbuget Nicola , Klinger Matthias , Viardot Andreas , Stelljes Matthias , Neumann Svenja , Horst Heinz-A. , Marks Reinhard , Faul Christoph , Diedrich Helmut , Reichle Albrecht , Brüggemann Monika , Holland Chris , Schmidt Margit , Einsele Hermann , Bargou Ralf C. , Topp Max S. 
Published: October 2015

Key Points
Ten of 36 patients (28%) achieved an OS ≥30 months in a blinatumomab study in relapsed/refractory acute lymphoblastic leukemia. Long-term survival may be associated with T-cell expansion, B-cell depletion, and a minimal residual disease response.
Novel biomarkers for risk stratification in pulmonary arterial hypertension
Authors: Zelniker Thomas , Uhlmann Lorenz , Spaich Sebastian , Friedrich Jörg , Preusch Michael R. , Meyer Franz J. , Katus Hugo A. , Giannitsis Evangelos 
Published: October 2015

Risk stratification in pulmonary arterial hypertension (PAH) is paramount to identifying individuals at highest risk of death. So far, there are only limited parameters for prognostication in patients with PAH.95 patients with confirmed PAH were included in the present analysis and followed for a total of 4 years. Blood samples were analysed for serum levels of N-terminal pro-brain natriuretic peptide, high-sensitivity troponin T (hsTnT), pro-atrial natriuretic peptide (proANP), growth differentiation factor 15, soluble fms-like tyrosine kinase 1 and placental growth factor.27 (28.4%) patients died during a follow-up of 4 years. Levels of all tested biomarkers, except for placental growth factor, were significantly elevated in nonsurvivors compared with survivors. Receiver operating characteristic analyses demonstrated that cardiac biomarkers had the highest power in predicting mortality. In particular, proANP exhibited the highest area under the curve, followed by N-terminal pro-brain natriuretic peptide and hsTnT. Furthermore, proANP and hsTnT added significant additive prognostic value to the established markers in categorical and continuous net reclassification index. Moreover, after Cox regression, proANP (hazard ratio (HR) 1.91), hsTnT (HR 1.41), echocardiographic right ventricular impairment (HR 1.30) and 6-min walk test (HR 0.97 per 10 m) remained the only significant parameters in prognostication of mortality.Our data suggest benefits of the implementation of proANP and hsTnT as additive biomarkers for risk stratification in patients with PAH.
Differential ability of MSCs isolated from placenta and cord as feeders for supporting ex vivo expansion of umbilical cord blood derived CD34+ cells
Authors: Kadekar Darshana , Kale Vaijayanti , Limaye Lalita 
Published: October 2015

Abstract
Introduction
Ex vivo expansion of umbilical cord blood (UCB) is attempted to increase cell numbers to overcome the limitation of cell dose. Presently, suspension cultures or feeder mediated co-cultures are performed for expansion of hematopoietic stem cells (HSCs). Mesenchymal stem cells (MSCs) have proved to be efficient feeders for the maintenance of HSCs. Here, we have established MSCs-HSCs co-culture system with MSCs isolated from less invasive and ethically acceptable sources like umbilical cord tissue (C-MSCs) and placenta (P-MSCs). MSCs derived from these tissues are often compared with bone marrow derived MSCs (BM-MSCs) which are considered as a gold standard. However, so far none of the studies have directly compared C-MSCs with P-MSCs as feeders for ex vivo expansion of HSCs. Thus, we for the first time performed a systematic comparison of hematopoietic supportive capability of C and P-MSCs using paired samples.

Methods
UCB-derived CD34+ cells were isolated and co-cultured on irradiated C and P-MSCs for 10 days. C-MSCs and P-MSCs were isolated from the same donor. The cultures comprised of serum-free medium supplemented with 25 ng/ml each of SCF, TPO, Flt-3 L and IL-6. After 10 days cells were collected and analyzed for phenotype and functionality.

Results
C-MSCs and P-MSCs were found to be morphologically and phenotypically similar but exhibited differential ability to support ex vivo hematopoiesis. Cells expanded on P-MSCs showed higher percentage of primitive cells (CD34+CD38−), CFU (Colony forming unit) content and LTC-IC (Long term culture initiating cells) ability. CD34+ cells expanded on P-MSCs also exhibited better in vitro adhesion to fibronectin and migration towards SDF-1α and enhanced NOD/SCID repopulation ability, as compared to those grown on C-MSCs. P-MSCs were found to be closer to BM-MSCs in their ability to expand HSCs. P-MSCs supported expansion of functionally superior HSCs by virtue of reduction in apoptosis of primitive HSCs, higher Wnt and Notch activity, HGF secretion and cell-cell contact. On the other hand, C-MSCs facilitated expansion of progenitors (CD34+CD38+) and differentiated (CD34−CD38+) cells by secretion of IL1-α, β, MCP-2, 3 and MIP-3α.

Conclusions
P-MSCs were found to be better feeders for ex vivo maintenance of primitive HSCs with higher engraftment potential than the cells expanded with C-MSCs as feeders.
p-adic Eisenstein-Kronecker series for CM elliptic curves and the Kronecker limit formulas
Authors: Bannai Kenichi , Furusho Hidekazu , Kobayashi Shinichi 
Published: October 2015

AbstractConsider an elliptic curve defined over an imaginary quadratic field K with good reduction at the primes above p ≥ 5 and with complex multiplication by the full ring of integers of K. In this paper, we construct p-adic analogues of the Eisenstein-Kronecker series for such an elliptic curve as Coleman functions on the elliptic curve. We then prove p-adic analogues of the first and second Kronecker limit formulas by using the distribution relation of the Kronecker theta function.
Prevalence of depressive symptoms in school aged children with type 1 diabetes – a questionnaire study.
Authors: Sendela Joanna , Zduńczyk Beata , Trippenbach-Dulska Hanna , Szypowska Agnieszka 
Published: October 2015

CelBadania pokazują, iż istnieje większe ryzyko rozwoju zaburzeń psychicznych u osób z cukrzycą w porównaniu z ogólna populacją. Celem pracy była ocena częstości występowania objawów depresji u dzieci w wieku szkolnym chorych na cukrzycę typu 1 (T1D).MetodaW badaniu wzięło udział 477 dzieci chorujących co najmniej rok na cukrzycę typu 1 w wieku 13,1 ± 2,7 lat. Średni czas choroby wynosił 5,0 ± 3,5 lat. Badani wypełniali polskie wersje kwestionariuszy: Inwentarza Depresji Dziecięcej (CDI) i Jakości Życia (QoL). Zbierano również dane demograficzne o wieku, masie ciała, czasie chorowania, dobowej dawce insuliny (TDD).Wyniki17% (81/477) badanych prezentowało symptomy depresji (CDI ≥ 13), wśród których 20,9% to dzieci ≥ 12 roku życia, a 8,1% ≤ 12 roku życia, p=0,0005. Badani z wynikiem CDI równym 13 i powyżej byli starsi (p=0,002), mieli większe BMI (p=0,029), TDD (p=0,026) i gorszą jakość życia (p<0,0001) w porównaniu z badanymi, którzy osiągnęli wynik <13. Nie było różnicy istotnej statystycznie w poziomie hemoglobiny glikowanej (HbA1c) między grupami z i bez objawów depresji (p=0,249).Istnieje korelacja między poziomem HbA1c, a wynikiem CDI (r = 0,16, p = 0,0002).WnioskiObjawy depresji są obserwowane u 1 na 12 dzieci z cukrzycą typu 1 w szkole podstawowej i u 1 na 5 nastolatków i mogą wpływać na kontrolę metaboliczną i jakość życia pacjentów, dlatego wczesne ich wykrywanie i zapobieganie powinny stać się standardem w leczeniu dzieci i młodzieży z cukrzycą typu 1.
The orthogonal-oblique bi-level model of the Outcome Questionnaire (OQ-45.2): Polish adaptation based on factor analysis
Authors: Simon Witold , Śliwka Piotr , Sobański Jerzy , Klasa Katarzyna , Sala Paweł , Żak Wojciech , Busath Gregory , Lambert Michael 
Published: October 2015

CelCelem niniejszego projektu było przeprowadzenie międzykulturowej walidacji Kwestionariusza Wyniku (Outcome Questionnaire, OQ-45.2) dla polskiej populacji.MetodaDane pozyskano od pacjentów psychoterapeutycznego oddziału dziennego (n = 211), pacjentów całodobowego ośrodka psychoterapeutycznego (n = 234), pacjentów psychoterapii ambulatoryjnej (n=137) oraz nie-pacjentów (n = 426). Zastosowano następujące metody statystyczne: metodę równoległą, eksploracyjną analizę czynnikową, konfirmacyjną analizę czynnikową, analizę współczynników korelacji, kryterium równoważności, kliniczną istotność i indeks rzetelnej zmiany, oraz metodę powtórnego testowania.WynikiAnalizy statystyczne wskazują na model dwupoziomowy – obejmujący wynik całkowity, pięć czynników ortogonalnych (podskale specyficzne dla polskiego OQ: Konflikty Społeczne i Zachowania Uzależnieniowe oraz oryginalne, lecz zmodyfikowane podskale: Nasilenie Objawów, Relacje Interpersonalne i Rola Społeczna) oraz dwa czynniki ukośne (Somatyzacja i Lęk oraz Rola Społeczna 2) – jako na najlepiej dopasowane do zebranych danych. Właściwości psychometryczne polskiego OQ są adekwatne i zbliżone zarówno do oryginalnego amerykańskiego narzędzia jak i jego międzynarodowych adaptacji. Ustalono specyficzne dla polskiego OQ punkty odcięcia służące do obliczania istotności klinicznej. Omówiono jak różnice międzykulturowe oraz upływ czasu mogą wpływać na uzyskane wyniki.WnioskiPolska wersja OQ 45-2 może zostać uznana za narzędzie adekwatnie mierzące funkcjonowanie jednostki zarówno w ogólnym zakresie jak i w kilku specyficznych obszarach. Wyniki niniejszej analizy czynnikowej wydają się być wartościowe nie tylko dla terapeutów korzystających z OQ-45, ale również dla badaczy, którzy tworzą narzędzia oceniające skuteczność psychoterapii.