bluuebunny/crossref_metadata_2025_split huggingface dataset:
POLÍTICAS PÚBLICAS DE EDUCAÇÃO A DISTÂNCIA E A DEMOCRATIZAÇÃO DO ACESSO: ACERTOS, PERCALÇOS E CONTRATEMPOS
Authors: Oliveira Régis Tribuzy de , Lucena Ketlen Karine Teles , Dantas Adriana Doroteu , Dutra Jurandir Moura 
Published: July 2024

Políticas Públicas de educação devem priorizar a universalização e a democraatização do ensino a todos os brasileiros, de forma igualitária de oportunidades. Sua construção deve atender aos interesses coletivos em consulta à sociedade. O Programa Reuni Digital, criado no âmbito da Secretaria Especial de Ensino Superior (SESu) do Ministério da Educação (MEC), teve como objetivo expandir a educação a distância nas universidades públicas federais, sabidamente por oferecer um ensino de qualidade. Das 69 instituições federais existentes, 13 aderiram e pactuaram propostas diferentes junto à SESu. A UFAM foi uma destas instituições, criando o curso de Tecnologia em Gestão Ambiental. A oferta atingiu 25 cidades do estado do Amazonas, cujas prefeituras foram signatárias de um Acordo de Cooperação Técnica, por meio de parceria, disponibilizando em contrapartida estrutura física e tecnológica, assim como pessoal para apoio didático-pedagógico. O modelo elaborado foi um sucesso, promoveu inclusão e estimulou a cooperação entre os alunos, resultando em taxas de sucesso e evasão, dignas de serem comemoradas, embora somente 1/6 do curso tenha sido executado, por ora. Contudo, novas ações corretivas devem ser implementadas, a fim de dar continuidade ao propósito inicial de formar e qualificar cidadãos em todos os lugares do Brasil, inclusive os mais remotos.
Efek Antidiabetes Infusa Daun Pepaya Jepang (Cnidoscolus aconitifolius Mill.) Pada Mencit (Mus musculus L.) Jantan dengan Metode Tes Toleransi Glukosa
Authors: Zakaria Nurmalia , Sari Amelia , Fauziah Fauziah , Handayani Rini 
Published: July 2024

Daun pepaya jepang (Cnidoscolus aconitifolius Mill.) dipercaya secara empiris dapat menurunkan kadar glukosa darah atau mengontrol kondisi hiperglikemik yang lebih ringan. Daun pepaya jepang memiliki aktivitas sebagai antihiperglikemia karena salah satu kandungan kimia yang terdapat pada daun pepaya jepang yaitu flavonoid dan saponin. Penelitian ini bertujuan untuk menentukan efek antidiabetes dari infusa daun pepaya jepang terhadap mencint jantan. Metode uji antidiabetes menggunakan metode Tes Toleransi Glukosa (TTG) terhadap tiga kelompok dosis perlakuan infus daun pepaya yaitu dosis 16,5 mg/20g BB; 33 mg/20g BB; dan 66 mg/20g BB, serta kelompok kontrol negatif dan kontrol positif. Hasil uji menunjukkan bahwa ketiga kelompok dosis infusa pepaya jepang memiliki efek antidiabetes dengan cara menurunkan kadar glukosa darah (KGD) mencit hingga menit ke-120 dengan persentase penurunan KGD secara berurutan yaitu 60,2%, 70,0% dan 71,8%. Nilai persentase penurunan KGD ketiga kelompok infusa daun pepaya jepang memberikan hasil yang berbeda secara signifikan dengan kontrol positif dan kontrol negatif yaitu 51,8% dan 24,2% (P<0,05). Efek antidiabetes dari ketiga infusa daun pepaya lebih tinggi dibandingkan dengan obat antidiabetes oral Metformin. Persentase penurunan KGD paling tinggi diberikan oleh infusa daun pepaya jepang dosis 66 mg/20 g BB dan tidak berbeda secara signifikan dengan infusa daun pepaya jepang dosis 33 mg/20g BB.
Kata kunci : Antidiabetes, Tes Toleransi Glukosa (TTG), Infusa Daun Pepaya Jepang, Penurunan Kadar Gula Darah (KDG)
CLINICAL CASE OF SYPHILITIC ANEURYSM OF THE AORTIC ARCH
Authors: Хубулава Геннадий Григорьевич , Эфендиев Видади Умудович , Садовой Сергей Валериевич , Минин Евгений Александрович , Яценко Ирина Анатольевна , Садовая Наталья Дмитриевна , Ногинов Владимир Константинович , Букур Александр Максимович 
Published: July 2024

С каждым годом по всему миру отмечается рост заболеваемости сифилисом. Его кардиоваскулярные осложнения при отсутствии должного лечения начинают проявляться спустя 15–30 лет после первичного заражения и могут сопровождаться поражением медии и адвентиции аорты. В дальнейшем патология аорты может манифестировать как острый аортальный синдром с высоким риском летальности, либо выявляться случайно в ходе обследования пациента. Нами представлен клинический случай успешного лечения сифилитической аневризмы дуги аорты, сопровождающейся сдавлением окружающих органов.
Every year there is an increase in the incidence of syphilis around the world. With the absence of proper treatment, cardiovascular complications begin to appear in 15–30 years after the initial infection and can be accompanied by damage to the media and adventitia of the aorta. Further aortic pathology may manifest as acute aortic syndrome with a high risk of mortality or be detected accidentally during examination of the patient. We present a clinical case of successful treatment of a syphilitic aortic arch aneurysm, accompanied by compression of surrounding organs.
A HYPERTROPHIC CARDIOMYOPATHY MASKED AS AN ACUTE CORONARY SYNDROME
Authors: Галенко Андрей Сергеевич , Соловьева Наталия Викторовна , Осипова Мария Валерьевна , Кузнецова Анна Владимировна 
Published: July 2024

Гипертрофическая кардиомиопатия, хотя и является наиболее часто встречающейся в практике первичной кардиомиопатией, зачастую служит причиной диагностических сложностей и даже ошибок. Для оценки частоты встречаемости заболевания среди госпитализированных пациентов проведен анализ работы кардиологических отделений многопрофильного городского стационара за 3,5 года, выявлены определенные клинические и морфологические особенности заболевания, дана их характеристика. Установлены основные факторы, препятствующие своевременной диагностике и возможные способы их преодоления.
Hypertrophic cardiomyopathy is the most frequent primary cardiomyopathy in clinical practice. Nevertheless, a number of diagnostic difficulties and even mistakes are happened due to the cardiomyopathy. Activity of cardiological departments in a multifunctional city hospital along 3,5 years was analyzed, frequency of hypertrophic cardiomyopathy among patients was established. Some specific anatomical and morphological features of the cardiomyopathy were found and characterized. The main factors hindering timely diagnostic have been identified and given someadvice to overcome them.
30th ISME World Conference: Pre-Conference Commission Seminar on Music in Special Education, Music Therapy and Music Medicine
Authors: Kaikkonen Markku 
Published: July 2024

30th ISME World ConferencePre-Conference Commission Seminar on Music in Special Education, Music Therapy and Music Medicine
12-14 July 2012
International Society for Music Education (ISME) and Greek Society for Music Education (GSME), University of Macedonia, Department of Educational and Social Policy Thessaloniki, Thessaloniki, Greece
Implementación de una interfaz cerebro computador para el efector final de un robot colaborativo UR3
Authors: Diaz Edwin , Vega Bryan , Chio Nayibe , Barragan Johann , Quiles Eduardo 
Published: July 2024

La imaginación motora en interfaces cerebro computador juega un papel cada vez más importante en la rehabilitación de trastornos motores y en la aplicación de múltiples tecnologías. Sin embargo, es un campo de investigación que tiene una gran trayectoria por delante, debido a la gran cantidad de variables que pueden cambiar los resultados de un experimento y que las señales EEG varían de un sujeto a otro. Por ello, se implementó una interfaz cerebro computador para controlar el efector final de un robot colaborativo UR3. La interfaz utiliza un Enobio 8 y la imaginación motora para la adquisición de la señal, MATLAB para el preprocesamiento, procesamiento, traducción y envío de comandos, y ROS para permitir la comunicación entre el MATLAB y el UR3.
Constructing Solar-Driven Photothermal Composite with High Mechanical Performance and Photothermal Conversion Efficiency via Covalent-Crosslinking
Authors: Wan Jianyong 
Published: July 2024

Integrating carbon nanotubes (CNT) and renewable biopolymers for producing solar-driven photothermal conversion materials exhibits unique advantages in cleanliness and controllability and represents a sustainable trend. However, such composites suffered from complex preparation processes, insufficient stability, leakage, photobleaching, and poor thermal conductivity. In harsh environments, corrosion resistance, mechanical properties, and photothermal conversion also face severe challenges. Here, we construct a CNT/natural polymer composite using carbohydrazide (CDH) as a block to covalent with sodium carboxymethyl cellulose (CMC) to prepare CMC-CDH networks, then combined with CNT to fabricate CMC-CDH-CNT film. As-prepared CMC-CDH-CNT film possessed extreme stability in harsh conditions and exhibited a high strength of 458.8 MPa, Young’s modulus of 18.8 GPa, and toughness of 13.3 MJ m−3. Besides, the CMC-CDH-CNT film also revealed an excellent photothermal conversion efficiency of 54.8%. CMC-CDH-CNT film showed good corrosion resistance, which led it to have high potential application in severe environments.
White Spot Lesions of Carious Etiology
Authors: Cosmina Ardelean Lavinia , Victoria Tigmeanu Codruta , Roi Alexandra , Rusu Laura-Cristina 
Published: July 2024

Demineralization-induced white spot lesions (WSL) are early non-cavitated carious lesions, representing the earliest stage of tooth decay, and appear as opaque, milky, porous areas, with a depth of only 40–130 μm. They are frequently found postfixed orthodontic treatment, because of the retentive nature of brackets and wires, and the inherent difficulties in maintaining proper oral hygiene, but can be found in non-orthodontic patients, as well. The main concern is of esthetic nature, but untreated WSL may evolve in dental caries, with important structural and functional consequences. The treatment approach more often uses conservative methods such as remineralization, microabrasion, tooth whitening, and resin infiltration, but, depending on the case, resin restorations and veneers may be involved. This chapter aims to discuss their etiology, characteristics and diagnosis, prevention and treatment methods, and to present three clinical cases of demineralized induced WSL, of orthodontic and non-orthodontic origin, treated by means of a microinvasive method, namely resin infiltration.
DNA Genetics and UHPLC-Q-TOF-MS Analysis of Phytochemicals for Asparagus racemosus Roots
Authors: Nguyen Thi Huong , Do Ngoc Thuy , Phung Van Trung , Le Ngoc Hung , Mai van Nam 
Published: July 2024

The medicinal herb Asparagus racemosus has been used in traditional medicine to treat various diseases such as cough, diarrhoea, diabetes, gastric issues, gonorrhoea, headaches, piles, rheumatism, and even lactation enhancement. This study explores the genetic information and phytochemicals of the species native to Gia Lai province, Vietnam before its conservation and cultivation. Five species of A. racemosus were analyzed using the trnL-e/trnL-f regions sequence. A. racemosus roots were extracted by water then Ultra-High-Performance Liquid Chromatography coupled with Quadrupole/Time-Of-Flight Mass Spectrometry (UHPLC-Q-TOF-MS) spectroscopy was used to screen for their phytochemicals. We have confirmed the DNA genetics of A. racemosus species collected in Gia Lai, Vietnam. In water extract of A. racemosus roots, UHPLC-Q-TOF-MS tentatively identified two flavonoids (Quercetin-3-glucuronide, Rutin), five steroidal saponins (Shatavarin I, Shatavarin IV, Shatavarin IX, Asparacoside, Asparanin A), and two steroids (β-sitosterol, Daucosterol). The experimental findings confirm the A. racemosus species for conservation and cultivation in Vietnam and contribute the benefits to the chemical literature of Vietnamese natural flora. A. racemosus should be further studied for pharmaceutical activities.
From Civil Society Organisations to Pirate Parties to Digital Democracy
Authors: Zakota Zoltan 
Published: July 2024

Reshaping our political and social systems for a sustainable future requires a multifaceted approach that addresses several key areas, such as: political reform, social change, economic development, environmental preservation, or technological innovation. In order to achieve a sustainable future, we need to implement its ideals in every societal sector. When dealing with the political system, we cannot ignore the antidemocratic tendencies arising or taking over our everyday life even in the Western World. Under these circumstances, political reform is a must and we have to admit that one of its most important tasks is strengthening democracy. The actual political discourse is full of ideas like proportional representation, direct democracy, sustainability-focused governance, transparency, accountability, and equity. Among the many actors that try to solve these problems there is a group that proposes some new solutions, based on the means of Information Society, Pirate Parties. Emerging from the digital world, they are a fresh wave of political movements with deep roots in online activism. These parties, some born from anti-establishment protests, have rapidly spread across the globe in just two decades. Their journey is one of transformation, from grassroots movements to established political players. Pirate Parties have a clear digital agenda, focusing on issues like copyright reform, open access to information, and online privacy. They champion net neutrality and the free flow of knowledge. However, most of them have recognized the importance of broader democratic values for political success. Beyond their digital focus, Pirate Parties also advocate for traditional democratic ideals, including civil rights, transparency, and combating corruption. They promote free speech, direct democracy, and exploring alternative forms of citizen participation in government, often leveraging technology (e-democracy). The future impact of Pirate Parties remains uncertain, but their influence is undeniable. They’ve challenged traditional political norms and brought issues of the digital age to the forefront. Pirate Parties have reshaped the European political landscape and inspired similar movements around the world. My paper aims to briefly present these political formations, with special regard to their origins in and their relations with civil society. After outlining the broad framework, I present some of the most notorious of these formations.
Impact of seedbed types and scarification methods on germination percentage and growth performance of Bambara groundnut (Vigna subterranea (L.) Verdc.) in the Sudan Savanna zone of Nigeria
Authors: Ibrahim A M , Bala U M , Halima M I 
Published: July 2024

The field experiments were conducted during the 2021 and 2022 wet seasons at The National Institute for Horticultural Research, Bagauda, and Hadejia-Jama’are River Basin Development Authority, Wudil, both in Kano State within the Sudan Savannah agro-ecological zone of Nigeria. The study aimed to find a better seedbed arrangement and the best scarification methods for good germination and growth of Bambara groundnut cultivars. The treatments consisted of four seedbed types (ridge, ridge+earthing, flat, and flat+earthing), four scarification methods (zero, mechanical, acid, and hot water treatments), and three cultivars (cream, black, and speckled). The treatments were factorially combined and laid out in a split-split plot design with three replications. Seedbed was assigned to the main plot, scarification methods were assigned to the subplot, and cultivars were assigned to the sub-subplot. Data collected were days to first emergence, establishment count (%), canopy height (cm), and kernel yield (kg ha-1). The result indicated that mechanically scarified Bambara groundnut seeds resulted in a higher establishment count and uniform canopy height (cm), which led to more dry matter accumulation and a higher kernel yield (kg ha-1).
Effect of halo priming on germination and growth parameters of finger millet, little millet, and barnyard millet under osmotic stress
Authors: Venothini S , Sujith Aastha S , Riya E , Soji Sunil A , Vinodha K , Ashokkumar Kaliyaperumal 
Published: July 2024

Seed priming has gained attention as a sustainable approach to improve crop performance. Halopriming, in particular, has shown promise in enhancing germination, growth, and stress tolerance. This study aimed to assess the effect of halopriming on the growth of finger millet (Eleusine coracana) variety CO(Ra) 15, little millet (Panicum sumatrense) variety ATL 1, and barnyard millet (Echinochloa frumentacea) variety CO(KV) 2 in osmotic conditions. The experiment used different salt solutions with 0, 1, and 1.8 g/L NaCl concentrations. In Hp1 (halo priming 1) finger millet variety CO(Ra) 15, 100% seed germination was observed in normal conditions. In Hp2, the little millet variety ATL 1 has shown 100% seed germination under osmotic stress with a concentration of 1 g/L NaCl (S1). In Hp1, barnyard millet variety CO(KV)2 showed 100% seed germination under osmotic stress with a concentration of 1.8 g/L NaCl (S2). Various growth parameters were recorded, and results showed that the barnyard millet variety Co (KV)2 and the little millet variety ATL 1, both under the Hp1 category, demonstrated the longest shoot lengths of 7.3 cm and 5.85 cm respectively under salt stress (S1). Furthermore, In Hp 1 finger millet variety CO(Ra) 15 recorded the highest root length of 12.25 under salt stress (S2). Vigour Index showed that Hp1 showed positive results regarding the germination percentage and seedling growth of finger millet variety CO(Ra) 15 and little millet variety ATL 1. This study suggested halopriming is an effective technique for promoting sustainable agriculture, especially in areas affected by salinity stress.
Media Used by English Teachers in Teaching Listening at Junior High School in Payakumbuh District
Authors: Roza Susanti  , Dwi Settya Mahaputri  
Published: July 2024

Listening is the activity of obtaining information about processes by listening to sounds. This study is a descriptive study using qualitative methods. The aim was to identify the media used by English teachers in listening classes at secondary schools in Payakumbuh district. Researchers conducted this study at a secondary school in Payakumbuh District. Twelve English teachers from Payakumbu District Middle School were selected through an open recruitment process. Researchers used questionnaires and interviews to obtain data. After conducting the study, the findings revealed that graphic media, which received percentages of 54.4% with a final score of 604, made up the majority of the materials used by English teachers to teach listening. Then, audio media received percentages of 25.4% and a score of 283. Audiovisual media, which is hardly often used, received percentages of 20.2% with a final score of 224. According to the data from the questionnaire and the teachers' responses from the interview, English teachers also employ graphic, audio, and audio visual media to teach listening. Thus, it can be said that listening skills were taught using media by English teachers at Payakumbuh District Junior High School.
PENGARUH KARAKTERISTIK KEWIRAUSAHAAN, KEPERCAYAAN DIRI, DAN KEUNGGULAN BERSAING TERHADAP KINERJA USAHA SENTRA KULINER (UMK) DI PERUMTAS 3 SIDOARJO
Authors: Sari Hanny Rosa Puspita , Mulyati Awin , Pratiwi Ni Made Ida 
Published: July 2024

Pelnelitlian ini belrtujuan untluk mengeltahui adalkah penlgaruh Karakteristik Kewilrausahaan, Kepercayaan Diri, dan Keunglgulan Bersaling Terlhadap Kinlerja Uslaha pada Sentra Kuliner Perumtas 3 di Sidoarjo. UMK di Indonesia telah membuat banyak kemajuan dalam beberapa tahun terakhir. Hal ini dikarenakan kapasitas mereka untuk menyerap sejumlah besar orang yang menganggur dan kontribusi mereka yalng signlifiklan terhladap Prolduk Domlestik Blruto. Uslaha Miklro Kelcil sendiri memiliki damlpak yalng signilfikan telrhadlap perelkonolmian naslional. Olleh karlena itlu, perlu adanya meningkatkan Karakteristik Kewirausahaan, meningkatkan Kepercayaan diri, meningkatkan keunggulan bersaing, dan juga meningkatkan kinerja usaha dengan cara memiliki pemahaman tentang Karakteristik Kewirausahaan, Kepercayaan Diri, dan Keunggulan bersaing. Sehingga pelaku usaha dapat mengembangkan strategi yang efektif untuk meningkatkan Kinerja Usaha. Penelitian ini menggunakan pendlekatan Kualntitlatif. Datla ini dikumpulkan dengan melalui kuesioner yang disebarkan kepada pelaku usaha sentra kuliner Perumtas 3 dengan jumlah 96 pelaku usaha. Teknik sampel yang digunakan yaitu teknik samlplling jenluh yalng telrmalsuk dallam jenlis nonl-probabillity sampling,sedangkan teknik analisis data menggunakan Uji Linier Berganda, Uji t, Uji F, Uji r (kolerasi), dan Uji R2 (koelfisilen detelrminlasi). Halsil penleliltian ini menulnjukkan bahlwa valrialbel Karakteristik Kewirausahaan, Kepercayaan Diri, dan Keunggulan Bersaing berpengaruh secara parsial maupun secara simultan terhadap Kinerja Usaha hal ini dikarenakan ketiga variabel tersebut saling mendukung dalam menciptakan lingkungan bisnis yang kompetitif.
Cellular uptake of allicin in the hCMEC/D3 human brain endothelial cells: exploring blood-brain barrier penetration in an in vitro model
Authors: Satsantitham Kankawi , Sritangos Pishyaporn , Wet-osot Sirawit , Chudapongse Nuannoi , Weeranantanapan Oratai 
Published: July 2024

Background
Allicin, a bioactive compound derived from garlic (Allium sativum), demonstrates antibacterial activity against a broad spectrum of bacteria including the most common meningitis pathogens. In order to advocate for allicin as a potential therapeutic candidate for bacterial meningitis, the present study aimed to assess the ability of allicin to cross the blood-brain barrier (BBB) using an in vitro model.

Methods
The cell viability of the human brain endothelial cell line hCMEC/D3 after incubation with various concentrations of allicin was investigated using an MTT assay at 3 and 24 h. Additionally, reactive oxygen species (ROS) production of allicin-treated hCMEC/D3 cells was examined at 3 h. The concentrations of allicin that were not toxic to the cells, as determined by the MTT assay, and did not significantly increase ROS generation, were then used to investigate allicin’s ability to traverse the in vitro BBB model for 3 h. High-performance liquid chromatography (HPLC) analysis was utilized to examine the allicin concentration capable of passing the in vitro BBB model. The cellular uptake experiments were subsequently performed to observe the uptake of allicin into hCMEC/D3 cells. The pkCSM online tool was used to predict the absorption, distribution, metabolism, excretion, and pharmacokinetic properties of allicin and S-allylmercaptoglutathione (GSSA).

Results
The results from MTT assay indicated that the highest non-toxicity concentration of allicin on hCMEC/D3 cells was 5 µg/ml at 3 h and 2 µg/ml at 24 h. Allicin significantly enhanced ROS production of hCMEC/D3 cells at 10 µg/ml at 3 h. After applying the non-toxicity concentrations of allicin (0.5–5 µg/ml) to the in vitro BBB model for 3 h, allicin was not detectable in both apical and basolateral chambers in the presence of hCMEC/D3 cells. On the contrary, allicin was detected in both chambers in the absence of the cells. The results from cellular uptake experiments at 3 h revealed that hCMEC/D3 cells at 1 × 104 cells could uptake allicin at concentrations of 0.5, 1, and 2 µg/ml. Moreover, allicin uptake of hCMEC/D3 cells was proportional to the cell number, and the cells at 5 × 104 could completely uptake allicin at a concentration of 5 µg/ml within 0.5 h. The topological polar surface area (TPSA) predicting for allicin was determined to be 62.082 Å2, indicating its potential ability to cross the BBB. Additionally, the calculated logBB value surpassing 0.3 suggests that the compound may exhibit ease of penetration through the BBB.

Conclusion
The present results suggested that allicin was rapidly taken up by hCMEC/D3 cells in vitro BBB model. The prediction results of allicin’s distribution patterns suggested that the compound possesses the capability to enter the brain.