bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computational modeling and uncertainty prediction of hyperelastic constitutive responses of damaged brain tissue under different temperature and strain rates
Authors: Meher Ashish Kumar , Srinivas A. Jyotiraditya , Kumar Vikash , Panda Subrata Kumar 
Published: August 2024

AbstractThe effect of strain rate and temperature on the hyperelastic material stress–strain characteristics of the damaged porcine brain tissue is evaluated in this present work. The desired constitutive responses are obtained using the commercially available finite element (FE) tool ABAQUS, utilizing 8‐noded brick elements. The model's accuracy has been verified by comparing the results from the previously published literature. Further, the stress–strain behavior of the brain tissue is evaluated by varying the damages at various strain rates and temperatures (13, 20, 27, and 37°C) under compression test. Additionally, the sensitivity analysis of the model is computed to check the effect of input parameters, that is, the temperature, strain rate, and damages on the material properties (shear modulus). The modeling and discussion sections enumerate the inclusive features and model capabilities.
Glucocorticoid modulates oxidative and thermogenic function of rat brown adipose tissue and human brown adipocytes
Authors: Bolin Anaysa Paola , de Fatima Silva Flaviane , Salgueiro Rafael Barrera , dos Santos Bruna Araújo , Komino Ayumi Cristina Medeiros , Andreotti Sandra , de Sousa Érica , de Castro Érique , Real Caroline Cristiano , de Paula Faria Daniele , Souza Gerson Profeta , Camara Henrique , Sorgi Carlos Arterio , Tseng Yu‐Hua , Lima Fábio Bessa , Rodrigues Alice Cristina 
Published: August 2024

AbstractChronic and excessive glucocorticoid (GC) exposure can cause Cushing's syndrome, resulting in fat accumulation in selected body areas. Particularly in the brown adipose tissue (BAT), GC acts negatively, resulting in whitening of the tissue. We hypothesized that dysregulation of microRNAs by GC could be an additional mechanism to explain its negative actions in BAT. Male Wistar rats were divided into two groups: (1) Control sham and (2) GC group that was administered dexamethasone 6.25 mg/200 μL via osmotic pump implantation over 28 days. After this period, the animals were euthanized and BAT tissue was properly stored. Human fat cells treated with dexamethasone were used to translate the experimental results found in animals to human biology. GC‐treated rat BAT presented with large lipid droplets, severely impaired thermogenic activation, and reduced glucose uptake measured by 18F‐FDG PET/CT. GC exposure induced a reduction in the mitochondrial OXPHOS system and oxygen consumption. MicroRNA profiling of BAT revealed five top‐regulated microRNAs and among them miR‐21‐5p was the most significantly upregulated in GC‐treated rats compared to the control group. Although upregulation of miR‐21‐5p in the tissue, differentiated primary brown adipocytes from GC‐treated rats had decreased miR‐21‐5p levels compared to the control group. To translate these results to the clinic, human brown adipocytes were treated with dexamethasone and miR‐21‐5p inhibitor. In human brown cells, inhibition of miR‐21‐5p increased brown adipocyte differentiation and prevented GC‐induced glucose uptake, resulting in a lower glycolysis rate. In conclusion, high‐dose GC therapy significantly impacts brown adipose tissue function, with a notable association between glucose uptake and miR‐21‐5p.
Formic and lactic acids from the conversion of xylose with the use of modified clinoptilolite by sonication
Authors: Sobuś Natalia , Król Magdalena 
Published: August 2024

AbstractBACKGROUNDA material of natural origin, clinoptilolite, was modified with selected metals in order to obtain a catalyst for the conversion of xylose – the main component of the hemicellulose fraction present in lignocellulosic biomass – to selected carboxylic acids.RESULTSThe starting material without modification (0‐parent), the hydrogen form (0‐hydrogen) of zeolite and zeolite after hierarchization with hydrochloric acid (0‐dealuminated) were used. Iron, copper and cobalt ions were introduced as active centers using the sonication technique. The catalytic process was carried out in a pressure autoclave for 2 h at a temperature of 220 °C. Compounds such as formic acid with a yield of 91% (0‐parent) and lactic acid with a yield of 66.1% (Fe‐hydrogen) were obtained.ConclusionThe catalytic processes carried out using xylose lead to the obtaining of a mixture of carboxylic acids: lactic acid, pyruvic acid and formic acid. An important role here is played by the presence of iron as an active site, which leads to the transformation of xylose into lactic acid by dehydration, and the presence of Lewis and Brønsted active sites. In the case of formic acid, which has never been reported in publications on a similar topic, the starting zeolite without modification contributed to its preparation. It is possible that the content of alkali metals contributed to its preparation along with the coupling of the oxidation reaction of the intermediate product, because of the presence of small amounts of iron, which are present in the natural material. © 2024 Society of Chemical Industry (SCI).
Removal of Escherichia coli and Enterococcus faecalis from synthetic wastewater using thermally treated palygorskite as a bacterial adsorbent in fixed bed reactors
Authors: Mavrikos Aristodimos , Tekerlekopoulou Athanasia.G , Venieri Danae , Lazaratou Christina.V , Vayenas Dimitris , Papoulis Dimitris 
Published: August 2024

AbstractBACKGROUNDIn pursuit of innovative wastewater treatment solutions, this study investigates the use of thermally treated palygorskite (TP) as an adsorbent to remove Escherichia coli and Enterococcus faecalis from synthetic wastewater. The goal is to explore a natural alternative to chlorine‐based disinfectants by utilizing TP's antimicrobial properties. Columns were packed with two granulometries (G1: 0.25–0.6 mm; G2: 1.40–2.36 mm) of TP and arranged in three different configurations (CA1, CA2 and CA3) to assess their bacterial removal efficiency, kinetic behavior and potential for reuse after dry heat sterilization.RESULTSThe CA3 column configuration, with its multilayer arrangement of TP, achieved the highest bacterial removal efficiency, reaching 99.1% for E. coli and 98.1% for E. faecalis. Kinetic experiments revealed that most bacterial adsorption occurred within the first 3 min, with E. coli requiring up to 10 min to reach maximum removal. TP's antibacterial effectiveness remained above 90% after two reuses. Additionally, dry heat sterilization allowed for repeated use of TP, showing stable removal efficiencies for E. faecalis and a slight decline for E. coli with each successive reuse.CONCLUSIONSTP demonstrates significant potential as an adsorbent for wastewater disinfection, particularly in the CA3 multilayer configuration. Its rapid adsorption kinetics and resilience to heat sterilization underscore its reusability, making it a viable natural alternative to chemical disinfectants. Further research should focus on scaling this method to real wastewater treatment applications to validate its functionality in real‐world conditions. © 2024 Society of Chemical Industry (SCI).
Standardizing visual display of gastrointestinal pathology results for improved clinical interpretation
Authors: Huang Jeannie S. , Lindgren Ann , Katibian David J. , Dickerson Andrew , Aceves Seema , Mo Jun , Malicki Denise , Tucker Suzanne M. 
Published: August 2024

AbstractObjectivesPathology is an essential component of disease diagnosis and management in pediatric gastroenterology. Pathology reports have not been standardized in some areas of pediatric gastrointestinal pathology and pathology reporting varies. Development of electronic medical record (EMR) pathology synoptic report templates (PSRT) enables pathology data collection in a specific format and can help standardize pathology reporting. We developed, implemented, and evaluated EMR PSRTs for eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD).MethodsPSRTs were developed by a multidisciplinary team of pediatric experts of allergy, gastroenterology, and pathology for both EoE and IBD based on available literature and validated scales. Likert surveys (range 1 low acceptance to 5 high acceptance) based on the Technology Acceptance Model assessed user acceptance of the developed PSRTs. The use of PSRTs was monitored via control charts.ResultsOverall, evaluation questionnaires achieved >80% response rates. Clinicians and pathologists reported moderate‐to‐high levels of Perceived Usefulness (median (interquartile range) for EoE PSRT: clinicians 4.0 (4.0, 5.0) and pathologists 3.5 (3.5, 4.0); and IBD PSRT: clinicians 4.0 (3.0, 4.0) and pathologists 4.0 (4.0, 5.0)) and Perceived Ease of Use (EoE PSRT: clinicians 4.5 (4.0, 5.0) and pathologists 4.0 (4.0, 4.0); and IBD PSRT: clinicians 4.0 (4.0, 5.0) and pathologists 4.0 (4.0, 5.0)) of the developed PSRTs. Control charts demonstrated 100% utilization by 2–5 months from launch.ConclusionsWe demonstrate successful implementation of synoptic reporting for both pediatric EoE and IBD pathology. EMR synoptic reporting provides standardization of pathology reporting and improved methods of pathology data presentation, which could potentially optimize provider efficiency, clinician interpretation of pathology results and disease trajectory, patient care, and clinician satisfaction.
Chaos theory perspective on tourism crisis management: A case study of the COVID‐19 pandemic in South Korea
Authors: Choi Jinyoung Olivia , Hyun Sunghyup Sean 
Published: August 2024

AbstractThe global tourism industry has been significantly affected by the COVID‐19 pandemic, underscoring the importance of innovative crisis management. Traditional crisis management approaches based on the generalized assumption of linearity fail to account for the complex and chaotic nature of tourism crises and systems. Chaos theory, well‐known for its ability to manage unpredictable events and facilitate the emergence of new orders, provides a useful framework for tourism crisis management. Thus, this study aims to investigate the application of chaos theory principles to crisis management during the COVID‐19 pandemic in South Korea. This study provides a synthesis of theoretical perspectives and practical examples with significant implications for tourism crisis management, emphasizing the importance of flexibility, adaptability, and collaboration. Overall, this study contributes to the theoretical discourse on tourism crisis management and provides practical guidance for industry stakeholders to navigate potential future crises effectively.
The moderating role of e‐word of mouth in the relationships between destination source credibility, awareness, attachment, travel motivation, and travel intention: A case study of Vietnamese film tourism
Authors: Luong The‐Bao 
Published: August 2024

AbstractBy adopting stimulus‐organism‐response theory, this study aims to investigate the role of destination source credibility, destination awareness, destination attachment, travel motivation, and e‐word of mouth (e‐WOM) in shaping audiences' travel intentions to visit locations depicted in movies or film series. A quantitative survey is conducted with 523 Vietnamese tourists, collecting their opinions on movie/film destinations. The findings highlight the significant influence of destination source credibility and travel motivation on destination attachment, further impacting travel intention. Additionally, the study reveals the effects of destination awareness, motivation, and attachment on travel intention. Notably, e‐WOM moderates the relationships between destination source credibility, travel intention, and destination attachment and travel intention. The study provides theoretical and practical implications, offering insights and suggestions for future research in the field.
m6A modification of VEGFA mRNA by RBM15/YTHDF2/IGF2BP3 contributes to angiogenesis of hepatocellular carcinoma
Authors: Xu Xiaoxin , Wu Shuxiang , Zhang Yi , Fan Weijie , Lin Xinjian , Chen Kunqi , Lin Xu 
Published: August 2024

AbstractVascular endothelial growth factor A (VEGFA) plays a critical role as a potent angiogenesis factor and is highly expressed in hepatocellular carcinoma (HCC). Although the expression of VEGFA has been strongly linked to the aggressive nature of HCC, the specific posttranscriptional modifications that might contribute to VEGFA expression and HCC angiogenesis are not yet well understood. In this study, we aimed to investigate the epitranscriptome regulation of VEGFA in HCC. A comprehensive analysis integrating MeRIP‐seq, RNA‐seq, and crosslinking‐immunprecipitation‐seq data revealed that VEGFA was hypermethylated in HCC and identified the potential m6A regulators of VEGFA including a m6A methyltransferase complex component RBM15 and the two readers, YTHDF2 and IGF2BP3. Through rigorous cell and molecular biology experiments, RBM15 was validated as a key component of methyltransferase complex responsible for m6A methylation of VEGFA, which was subsequently recognized and stabilized by IGF2BP3 and YTHDF2, leading to enhanced VEGFA expression and VEGFA‐related functions such as human umbilical vascular endothelial cells (HUVEC) migration and tube formation. In the HCC xenograft model, knockdown of RBM15, IGF2BP3, or YTHDF2 resulted in reduced expression of VEGFA, accompanied by significant inhibition of tumor growth closely associated with VEGFA expression and angiogenesis. Furthermore, our analysis of HCC clinical samples identified positive correlations between the expression levels of VEGFA and the regulators RBM15, IGF2BP3, and YTHDF2. Collectively, these findings offer novel insights into the posttranscriptional modulation of VEGFA and provide potential avenues for alternative approaches to antiangiogenesis therapy targeting VEGFA.
Utilization of antiobesity medications within the Military Health System
Authors: Neuman Taylor , Corrado Richele , Banaag Amanda , Koehlmoos Tracey Perez 
Published: August 2024

AbstractObjectiveThe prevalence of overweight and obesity among beneficiaries of the Military Health System (MHS) is 41.6% and 30.5%, respectively. This incurs significant medical, fiscal, and military readiness costs. It is not currently known how the utilization of antiobesity medications (AOMs) within the MHS compares with that in the Veterans Health Administration or the private sector. Our aim was to assess the utilization of AOMs within the MHS.MethodsA cross‐sectional study was conducted using data gathered from the MHS Data Repository and the inclusion of all adult TRICARE Prime and Plus beneficiaries ages 18 to 64 years who were prescribed at least one TRICARE‐approved AOM during the years 2018 to 2022.ResultsThe total study population included 4,414,127 beneficiaries, of whom 1,871,780 were active‐duty service members. The utilization of AOMs among the eligible population was 0.56% (0.44% among active‐duty personnel). Liraglutide was the most‐prescribed AOM (36% of the total). Female sex, age greater than or equal to 30 but less than 60 years, and enlisted or warrant officer rank were all associated with statistically significant higher odds of receiving AOMs.ConclusionsComparable with the US private sector, the MHS significantly underutilizes AOMs, including among active‐duty service members, despite coverage of AOMs since 2018.
Vaccinium corymbosum–Derived Carbon Dots and Anthocyanin‐Infused Gelatin Multifunctional Films for Smart Packaging Applications
Authors: Wagh Rajesh V. , Ezati Parya , Khan Ajahar , Priyadarshi Ruchir , Rhim Jong‐Whan 
Published: August 2024

ABSTRACTConsumers and food industry stakeholders have expressed great interest in using simple, non‐destructive and inexpensive methods to control/maintain or monitor the freshness of perishable foods. The idea of smart packaging has been introduced to address these requirements satisfactorily, revolutionizing conventional food packaging. Vaccinium corymbosum (VC)–based carbon dots (CDs) and anthocyanin were matrixed on gelatin (GEL) to fabricate smart packaging film. The VC biowaste–derived carbon dots (VC‐CDs) were characterized using photoluminescence, fluorescence spectrometry, FTIR, antibacterial/antioxidant potential, TEM and XPS analysis. Fabricated films were subjected to physico‐chemical, antioxidant and optical properties, SEM, TGA simulation and in vivo food model system. The VC‐CDs exhibited excellent functional properties like ultraviolet (UV) blocking and antibacterial properties. The reinforcement with 1.5% VC‐CDs and 6% VC anthocyanins (VCA) in the GEL polymer matrix improved UV blocking (> 189%) properties and showed potent antioxidant potential (> 164%) compared to the neat GEL film. In vivo food packaging (minced pork, fish and shrimp) with films has shown that indicator films work efficiently and non‐destructively and monitor real‐time freshness. The GEL/VC‐CDs/VCA‐based active and intelligent films are expected to be applied as multifunctional nanocomposite packaging materials that can indicate quality changes in real time, maintain quality and prolong the shelf life of packaged foods.
In Situ Measurement of the Non‐Orthogonal Angles of Magnetic Field Coils Based on Single‐Beam Magnetic Resonance
Authors: Liu Zhi , Dong Lihong , Qi Zhe , Zhu Hongyang , Zhao Bingquan , Zhao Xiaoming 
Published: August 2024

AbstractThis work proposes a novel method for in situ measurement of the non‐orthogonal angles of magnetic field coils based on single‐beam magnetic resonance. The orthogonality of magnetic field coils is crucial for ensuring the accuracy of atomic magnetometers. The theoretical principles are derived to establish a measurement method for the non‐orthogonal angles. The proposed method requires only one single beam of light to perform in situ measurements of non‐orthogonal angles in the YZ and XZ directions. The experimental results demonstrate that the angle between the Y and Z coils is 89.3001 ± 0.0045°, a value that remains stable despite variations in experimental parameters such as temperature and light power, thereby confirming the robustness of the method. Additionally, the measured gyromagnetic ratio is 6.9963 ± 0.0005 Hz nT−1, which closely matches the theoretical value of 6.9958 Hz nT−1, further validating the method's accuracy. The proposed method provides a more straightforward approach and has significant potential for widespread application across various atomic magnetometers, especially in miniaturized configurations. Furthermore, this method may be extended to the field of atomic gyroscopes.
Asynchronous control of continuous‐time switched systems with all unstable modes under DoS attacks
Authors: Huang Guoxuan , Du Yingxue , Zhang Ancai , Liu Yang , Liu Zhi 
Published: August 2024

AbstractIn this article, the asynchronous control problem of switched linear systems with all unstable modes under denial‐of‐service (DoS) attacks is studied. First, the upper bound of the sampling period, which can be easily calculated based on the scenario where all modes are unstable, is obtained under a periodic sampling control strategy. Second, by constructing an appropriate discrete multiple linear quadratic Lyapunov function, an asynchronous control scheme in the form of linear matrix inequalities is devised. To ensure the stability of switched systems under DoS attacks, a sufficient condition for the total duration and frequency of DoS attacks is established. It is shown that the switched system can tolerate DoS attacks up to a certain limit while maintaining exponential stability, and this result is applicable even when all subsystems are unstable. Finally, numerical examples and a comparative study are presented to demonstrate the effectiveness of the proposed method.
Environmental, social and governance (ESG) disclosure and firm performance: Moderating role of board gender diversity and sustainability committee
Authors: Alodat Ahmad Yuosef , Hao Yunhong 
Published: August 2024

AbstractThis paper aims to investigate the moderating effect of board gender diversity (BGD) and sustainability committee in the relationship between environmental, social and governance (ESG) disclosure and the performance of the firm in European countries. This study encompasses an analysis of data obtained from non‐financial firms listed in European markets spanning the years 2013–2022. The findings indicate that ESG disclosure has a pronounced and statistically significant influence on the performance of the firms. Furthermore, BGD plays a positive moderating role in enhancing the relationship between ESG disclosure and ROA. In addition, the sustainability committee showed a moderate positive relationship. The findings have substantial managerial implications for professionals spanning different sectors, such as practitioners, policymakers, senior executives, and corporate leaders. Firms are advised to strategically consider board restructuring to enhance effectiveness in overseeing and advancing ESG practices. Prioritizing ESG efforts is recommended as it enhances overall performance, with investing in gender diversity on boards further strengthening this relationship. Establishing a dedicated sustainability committee can also positively impact firm outcomes, highlighting the importance of proactive ESG integration within corporate strategies. Analyzing the role of BGD as a moderating factor represents a valuable addition to the current body of research. It enhances our comprehension of how ESG disclosure indirectly influences firm performance.
Highly Stable CsPbBr3@MoS2 Nanostructures: Synthesis and Optoelectronic Properties Toward Implementation into Solar Cells
Authors: Goldreich Achiad , Prilusky Jonathan , Prasad Neena , Puravankara Akshay , Yadgarov Lena 
Published: August 2024

AbstractHalide perovskites (HPs) have gained significant interest in the scientific and technological sectors due to their unique optical, catalytic, and electrical characteristics. However, the HPs are prone to decomposition when exposed to air, oxygen, or heat. The instability of HP materials limits their commercialization, prompting significant efforts to address and overcome these limitations. Transition metal dichalcogenides, such as MoS2, are chemically stable and are suitable for electronic, optical, and catalytic applications. Moreover, it can be used as a protective media or shell for other nanoparticles. In this study, a novel CsPbBr3@MoS2 core–shell nanostructure (CS‐NS) is successfully synthesized by enveloping CsPbBr3 within a MoS2 shell for the first time. Significant stability of CS‐NSs dispersed in polar solvents for extended periods is also demonstrated. Remarkably, the hybrid CS‐NS exhibits an absorption of MoS2 and quenching of the HP's photoluminescence, implying potential charge or energy transfer from HPs to MoS2. Using finite difference time domain simulations, it is found that the CS‐NSs can be utilized to produce efficient solar cells. The addition of a MoS2 shell enhances the performance of CS‐NS‐based solar cells by 220% compared to their CsPbBr3 counterparts. The innovative CS‐NS represents important progress in harnessing HPs for photovoltaic and optoelectronic applications.