bluuebunny/crossref_metadata_2025_split huggingface dataset:
A compensation model of cooperative downloading for vehicular network
Authors: Liu Jianhang , Bi Jingping , Ge Yuming , Cui Xuerong , Ding Shuyan , Li Zhongcheng 
Published: March 2013

ABSTRACTThe ever growing dependence on the Internet makes people keen on accessing the network anytime and anywhere, even while driving cars. Cooperative downloading among vehicles could help the clients obtain more data when running out of access point coverage area. One of the methods is that the access point predicts communication duration between the helper and the client according to the registered speed of vehicles to decide how many packets should be carried by the helper. However, it is possible that cooperative vehicles cannot always transmit all of the carried data to the client due to the changing speed. A key challenge that lies at the heart of this problem is how to increase the packet transmitting rate of cooperative vehicles. Towards the end, this paper proposes a novel compensation model that exploits nodes own regulatory function to mitigate the packet transmission loss. By analysing a real speed dataset collected from a test car with global positioning system running from May 2011 to July 2012 on the No. G15 highway in China, we derive a strong spatiotemporal regularity in vehicle speeds. Impending speed can be predicted, therefore, using Markov chain. On the basis of the aforementioned quantitative prediction, the compensation schemes is presented to increase received data amount by using the characteristics of encountering, overtaking and being overtaken among vehicles. Simulation results indicate the benefits of the proposed model in terms of increasing throughput and reducing delay. Copyright © 2013 John Wiley & Sons, Ltd.
Recurrent NCOA2 gene rearrangements in congenital/infantile spindle cell rhabdomyosarcoma
Authors: Mosquera Juan Miguel , Sboner Andrea , Zhang Lei , Kitabayashi Naoki , Chen Chun‐Liang , Sung Yun Shao , Wexler Leonard H. , LaQuaglia Michael P. , Edelman Morris , Sreekantaiah Chandrika , Rubin Mark A. , Antonescu Cristina R. 
Published: March 2013

AbstractSpindle cell rhabdomyosarcoma (RMS) is a rare form of RMS with different clinical characteristics between children and adult patients. Its genetic hallmark remains unknown and it remains debatable if there is pathogenetic relationship between the spindle cell and the so‐called sclerosing RMS. We studied two pediatric and one adult spindle cell RMS by next generation RNA sequencing and FusionSeq data analysis to detect novel fusions. An SRF‐NCOA2 fusion was detected in a spindle cell RMS from the posterior neck in a 7‐month‐old child. The fusion matched the tumor karyotype and was confirmed by FISH and RT‐PCR, which showed fusion of SRF exon 6 to NCOA2 exon 12. Additional 14 spindle cell (from 8 children and 6 adults) and 4 sclerosing (from 2 children and 2 adults) RMS were tested by FISH for the presence of abnormalities in NCOA2, SRF, as well as for PAX3 and NCOA1. NCOA2 rearrangements were found in two additional spindle cell RMS from a 3‐month‐old and a 4‐week‐old child. In the latter tumor, TEAD1 was identified by rapid amplification of cDNA ends (RACE) to be the NCOA2 gene fusion partner. None of the adult tumors were positive for NCOA2 rearrangement. Despite similar histomorphology in adults and young children, these results suggest that spindle cell RMS is a heterogeneous disease genetically as well as clinically. Our findings also support a relationship between NCOA2‐rearranged spindle cell RMS occurring in young childhood and the so‐called congenital RMS, which often displays rearrangements at 8q13 locus (NCOA2). © 2013 Wiley Periodicals, Inc.
Tissue metabolomics of hepatocellular carcinoma: Tumor energy metabolism and the role of transcriptomic classification
Authors: Beyoğlu Diren , Imbeaud Sandrine , Maurhofer Olivier , Bioulac-Sage Paulette , Zucman-Rossi Jessica , Dufour Jean-François , Idle Jeffrey R. 
Published: March 2013

Abstract

Hepatocellular carcinoma (HCC) is one of the commonest causes of death from cancer. A plethora of metabolomic investigations of HCC have yielded molecules in biofluids that are both up- and down-regulated but no real consensus has emerged regarding exploitable biomarkers for early detection of HCC. We report here a different approach, a combined transcriptomics and metabolomics study of energy metabolism in HCC. A panel of 31 pairs of HCC tumors and corresponding nontumor liver tissues from the same patients was investigated by gas chromatography-mass spectrometry (GCMS)-based metabolomics. HCC was characterized by ˜2-fold depletion of glucose, glycerol 3- and 2-phosphate, malate, alanine, myo-inositol, and linoleic acid. Data are consistent with a metabolic remodeling involving a 4-fold increase in glycolysis over mitochondrial oxidative phosphorylation. A second panel of 59 HCC that had been typed by transcriptomics and classified in G1 to G6 subgroups was also subjected to GCMS tissue metabolomics. No differences in glucose, lactate, alanine, glycerol 3-phosphate, malate, myo-inositol, or stearic acid tissue concentrations were found, suggesting that the Wnt/β-catenin pathway activated by CTNNB1 mutation in subgroups G5 and G6 did not exhibit specific metabolic remodeling. However, subgroup G1 had markedly reduced tissue concentrations of 1-stearoylglycerol, 1-palmitoylglycerol, and palmitic acid, suggesting that the high serum α-fetoprotein phenotype of G1, associated with the known overexpression of lipid catabolic enzymes, could be detected through metabolomics as increased lipid catabolism. Conclusion: Tissue metabolomics yielded precise biochemical information regarding HCC tumor metabolic remodeling from mitochondrial oxidation to aerobic glycolysis and the impact of molecular subtypes on this process. (HEPATOLOGY 2013)
Lactoferricin mediates anti‐inflammatory and anti‐catabolic effects via inhibition of IL‐1 and LPS activity in the intervertebral disc
Authors: Kim Jae‐Sung , Ellman Michael B. , Yan Dongyao , An Howard S. , KC Ranjan , Li Xin , Chen Di , Xiao Guozhi , Cs‐Szabo Gabriella , Hoskin David W. , Buechter Doug D. , Van Wijnen Andre J. , Im Hee‐Jeong 
Published: March 2013

AbstractThe catabolic cytokine interleukin‐1 (IL‐1) and endotoxin lipopolysaccharide (LPS) are well‐known inflammatory mediators involved in degenerative disc disease, and inhibitors of IL‐1 and LPS may potentially be used to slow or prevent disc degeneration in vivo. Here, we elucidate the striking anti‐catabolic and anti‐inflammatory effects of bovine lactoferricin (LfcinB) in the intervertebral disc (IVD) via antagonism of both IL‐1 and LPS‐mediated catabolic activity using in vitro and ex vivo analyses. Specifically, we demonstrate the biological counteraction of LfcinB against IL‐1 and LPS‐mediated proteoglycan (PG) depletion, matrix‐degrading enzyme production, and enzyme activity in long‐term (alginate beads) and short‐term (monolayer) culture models using bovine and human nucleus pulposus (NP) cells. LfcinB significantly attenuates the IL‐1 and LPS‐mediated suppression of PG production and synthesis, and thus restores PG accumulation and pericellular matrix formation. Simultaneously, LfcinB antagonizes catabolic factor mediated induction of multiple cartilage‐degrading enzymes, including MMP‐1, MMP‐3, MMP‐13, ADAMTS‐4, and ADAMTS‐5, in bovine NP cells at both mRNA and protein levels. LfcinB also suppresses the catabolic factor‐induced stimulation of oxidative and inflammatory factors such as iNOS, IL‐6, and toll‐like receptor‐2 (TLR‐2) and TLR‐4. Finally, the ability of LfcinB to antagonize IL‐1 and LPS‐mediated suppression of PG is upheld in an en bloc intradiscal microinjection model followed by ex vivo organ culture using both mouse and rabbit IVD tissue, suggesting a potential therapeutic benefit of LfcinB on degenerative disc disease in the future. J. Cell. Physiol. 228: 1884–1896, 2013. © 2013 Wiley Periodicals, Inc.
Thermoplastic Polyurethanes From Undecylenic Acid‐Based Soft Segments: Structural Features and Release Properties
Authors: Lluch Cristina , Lligadas Gerard , Ronda Joan C. , Galià Marina , Cádiz Virginia 
Published: March 2013

AbstractA set of thermoplastic polyurethanes is synthesized, combining undecylenic acid‐derived telechelic diols as soft segments and 1,4‐butanediol/4,4′‐methylenebis(phenylisocyanate) as a hard segment (HS). These polymers are fully chemically and physically characterized by means of NMR and Fourier transform IR (FTIR) spectroscopy, size‐exclusion chromatography (SEC), DSC, thermogravimetric analysis (TGA), tensile testing, and contact angle measurements. The obtained results reveal that both the molecular weight of the diol and the HS content greatly influence the physical and mechanical properties of these polymers. In addition, given the potential use of these materials for biomedical applications, hydrolytic degradation, their biocompatibility using a human fibroblast cell line, and performance as drug delivery carriers are evaluated. magnified image
Polythiophene Diblock Copolymer with Different Solvent Affinities of the Side‐Chain Substituents: Solvatochromism and Effect on the Electronic Conjugation
Authors: Angiolini Luigi , Brazzi Alice , Salatelli Elisabetta , Van den Bergh Karlien , Koeckelberghs Guy 
Published: March 2013

AbstractA new diblock copolymer composed of a regioregular block of poly[3‐[2‐(2‐methoxyethoxy)ethoxy]methylthiophene], bearing as side‐chain a hydrophilic substituent, and a regioregular block of poly[3‐(1‐octyloxy)thiophene], is prepared and characterized. The properties are compared with those of a related copolymer composed of poly(3‐hexylthiophene) and poly(3‐alkoxythiophene) blocks. The solvatochromic properties of these materials in solution are investigated by absorption and emission spectroscopy upon gradual addition of a poor solvent, and compared with those of the parent regioregular homopolymers. The experimental results are interpreted in terms of electronic interactions between the blocks. It is found that the different hydrophilicity of the side chain plays a crucial role for the electronic communication between blocks in poly(3‐alkylthiophene)‐block‐poly(3‐alkoxythiophene) copolymers.magnified image
Novel Test System for Gas Sensing Materials and Sensors
Authors: Stewart K. M. E. , Penlidis A. 
Published: March 2013

AbstractSummary: A growing interest in gas sensors necessitates the requirement for a test system that is reliable and capable of handling multiple gas analytes at various concentrations. Most test systems currently used do not incorporate some type of standard with which to verify the actual concentrations of the gas analytes being tested, but rather calculate concentrations indirectly. The problem is that the calculated concentrations rarely take into account any loss that may occur across the test system. The test system described herein uses a specialized gas chromatograph (GC) that is capable of detecting down to the ppb range. It can either be used to screen potential sensing materials or to verify the actual concentration being tested for a specific sensor.
State of the art of the gateroads in Polish coal mining
Authors: Prusek Stanislaw , Masny Wojciech 
Published: March 2013

AbstractGateroads play an important role in the process of hard coal mining. Maintaining an appropriate cross‐section for these workings is one of the fundamental factors that determine both production results and the occupational safety of the mine personnel. The paper describes the most important data in the field of gateroad support characteristics as well as gateroad design methods. Due to the fact that significant difficulties may arise from vertical and horizontal convergence occurring in gateroads, the article discusses this issue as well.
Respiration based steering for high intensity focused ultrasound liver ablation
Authors: Holbrook Andrew B. , Ghanouni Pejman , Santos Juan M. , Dumoulin Charles , Medan Yoav , Pauly Kim Butts 
Published: March 2013

PurposeRespiratory motion makes hepatic ablation using high intensity focused ultrasound (HIFO) challenging. Previous HIFU liver treatment had required apnea induced during general anesthesia. We describe and test a system that allows treatment of the liver in the presence of breathing motion.MethodsMapping a signal from an external respiratory bellow to treatment locations within the liver allows the ultrasound transducer to be steered in real time to the target location. Using a moving phantom, three metrics were used to compare static, steered, and unsteered sonications: the area of sonications once a temperature rise of 15°C was achieved, the energy deposition required to reach that temperature, and the average rate of temperature rise during the first 10 s of sonication. Steered HIFU in vivo ablations of the porcine liver were also performed and compared to breath‐hold ablations.ResultsFor the last phantom metric, all groups were found to be statistically significantly different (P ≤ 0.003). However, in the other two metrics, the static and unsteered sonications were not statistically different (P > 0.9999). Steered in vivo HIFU ablations were not statistically significantly different from ablations during breath‐holding.ConclusionsA system for performing HIFU steering during ablation of the liver with breathing motion is presented and shown to achieve results equivalent to ablation performed with breath‐holding. Magn Reson Med 71:797–806, 2014. © 2012 Wiley Periodicals, Inc.
Single shot fast spin echo diffusion imaging with correction for non‐linear phase errors using tailored RF pulses
Authors: Nunes Rita G. , Malik Shaihan J. , Hajnal Joseph V. 
Published: March 2013

PurposeThe use of tailored RF excitation pulses for prospective correction of non‐linear motion‐induced phase patterns is shown to enable diffusion‐weighted (DW) fast spin echo (FSE) imaging in vivo. Echo‐planar imaging (EPI) remains the most used sequence for DW imaging. Despite being highly sensitive to field inhomogeneities, EPI is robust to motion‐induced phase shifts. FSE sequences are much less sensitive to field inhomogeneities, but require precise control of the transverse magnetization phase, which is hard to achieve with DW. Real time measurements and correction of phase ramps due to rigid‐body motion had been proposed, but performance remained unsatisfactory because of non‐linear phase patterns related to pulsatile motion.MethodsReproducible non‐linear phase components are calibrated using 2D‐EPI navigators and tailored RF excitation pulses designed. Real time correction of rigid‐body motion was not yet implemented.ResultsPhase correction was confirmed with full signal DW‐FSE images obtained on co‐operative subjects. Full diffusion tensor acquisitions were obtained and color‐coded maps displaying principal fiber directionality calculated. Results were consistent with corresponding EPI acquisitions except for absence of spatial distortions.ConclusionCombining the proposed method with real time compensation of rigid‐body motion has the potential to allow high quality, distortion free diffusion imaging throughout the brain. Magn Reson Med 71:691–701, 2014. © 2013 Wiley Periodicals, Inc.
miR‐152 controls migration and invasive potential by targeting TGFα in prostate cancer cell lines
Authors: Zhu Chen , Li Jie , Ding Qi , Cheng Gong , Zhou Hai , Tao Liangjun , Cai Hongzhou , Li Pu , Cao Qiang , Ju Xiaobing , Meng Xiaoxin , Qin Chao , Hua Lixin , Shao Pengfei , Yin Changjun 
Published: March 2013

AbstractBACKGROUNDMicroRNAs (miRNAs) are a class of short non‐coding RNAs that function in diverse biological processes. Aberrant miR‐152 expression has been frequently reported in various malignant tumors. However, the mechanism of miR‐152 in prostate cancer (PCa) remains unclear. This study aims to determine the function of miR‐152 in PCa cells and identify the novel molecular targets regulated by miR‐152.METHODSThe expression levels of transforming growth factor‐alpha (TGFα) were determined in three samples of PCa and adjacent non‐tumorous tissues by Western blot analysis. miR‐152 levels in 48 primary PCa and 15 non‐malignant tissue samples were measured by qRT‐PCR. The effects of forced miR‐152 expression or TGFα knockdown on PCa cells were evaluated by cell migration and invasion assays, as well as Western blot analysis. Dual‐luciferase reporter assay was used to identify binding sites between miR‐152 and TGFα 3′‐UTR.RESULTSTGFα was upregulated in PCa tissue samples compared with that in adjacent normal ones. miR‐152 expression was significantly decreased in primary PCa samples compared with that in non‐malignant samples. Patients with Gleason scores >7 exhibited lower miR‐152 levels than those with lower scores. Moreover, low miR‐152 expression is correlated with advanced pathological T‐stages. Forced miR‐152 expression or TGFα knockdown significantly reduced the migratory and invasive capabilities of PCa cells in vitro. TGFα is a direct target gene of miR‐152.CONCLUSIONSOur findings suggest that miR‐152 can act as a tumor suppressor that targets TGFα. miR‐152 is a promising molecular target that inhibits PCa cell migration and invasion. Prostate 73: 1082–1089, 2013. © 2013 Wiley Periodicals, Inc.
Recoverable values for independent sets
Authors: Feige Uriel , Reichman Daniel 
Published: March 2013

AbstractThe notion of recoverable value was advocated in the work of Feige, Immorlica, Mirrokni and Nazerzadeh (APPROX 2009) as a measure of quality for approximation algorithms. There, this concept was applied to facility location problems. In the current work we apply a similar framework to the maximum independent set problem (MIS). We say that an approximation algorithm has recoverable factor ρ, if for every graph it recovers an independent set of size at least

urn:x-wiley:10429832:media:rsa20492:rsa20492-math-0001

where d(v) is the degree of vertex v, and I ranges over all independent sets in G. Hence, in a sense, from every vertex v in the maximum independent set the algorithm recovers a value of at least toward the solution. This quality measure is most effective in graphs in which the maximum independent set is composed of low degree vertices. A simple greedy algorithm achieves . We design a new randomized algorithm for MIS that ensures an expected recoverable factor of at least . In passing, we prove that approximating MIS in graphs with a given k‐coloring within a ratio larger than 2/ k is unique‐games hard. This rules out an alternative approach for obtaining . © 2013 Wiley Periodicals, Inc. Random Struct. Alg., 46, 142–159, 2015
Effects of Ar‐ and Ar/O2‐plasma‐treated amorphous and crystalline polymer surfaces revealed by ToF‐SIMS and principal component analysis
Authors: Ren Xianwen , Weng Lu‐Tao , Ng Kai‐Mo , Chan Chi‐Ming 
Published: March 2013

AbstractThe effects of argon (Ar) and a mixture of Ar and oxgyen(Ar/O2) plasmas on amorphous and semi‐crystalline poly(bisphenol A hexane ether) thin films were investigated by time‐of‐flight secondary ion mass spectroscopy (ToF‐SIMS) and principal component analysis (PCA). PCA results of the ToF‐SIMS spectra indicate that an Ar/O2 plasma produced less physical sputtering and had a higher chemical reactivity than did an Ar plasma, regardless of whether an amorphous or a crystalline surface was involved. However, the chemical differences between the Ar‐ and Ar/O2‐plasma‐treated semi‐crystalline films were much smaller. The observed results can be explained by the higher resistance of the polymer crystalline regions to physical sputtering and chemical etching. Copyright © 2013 John Wiley & Sons, Ltd.
Mechanochemical Synthesis and Characterization of Hydrated and Dehydrated Crystalline Strontium Terephtalates
Authors: Scholz Gudrun , Emmerling Franziska , Dreger Maik , Kemnitz Erhard 
Published: March 2013

AbstractA successful mechanochemical synthesis of strontium terephthalate trihydrate is described for the first time. The dehydration of Sr(C8H4O4)·3H2O occurs at about 100 °C and results in a well‐defined strontium terephtalate, Sr(C8H4O4), thermally stable up to 550 °C. Both compounds are not described so far in the literature. Their structures were solved by ab initio structure determination and subsequent Rietveld refinement of the powder diffraction data. Further methods like DTA‐TG, MAS NMR and FT‐IR spectroscopy, and BET measurements were used to characterize these compounds.
Structural Control on Landscape Development of Barak Valley, Northeast India
Authors: Laskar A. Alam , Phukon P. 
Published: March 2013

Abstract:
The Barak Valley, comprising a contiguous region of three south Assam districts of Cachar, Hailakandi and Karimganj, represents a ridge and valley province with meridional to sub-meridional anticlinal hills and synclinal valleys. Thin skinned tectonics resulted in the deformation of Neogene clastics which is manifested in the form of a series of anticlines and synclines. These structural elements have profound control on the development of present-day landscape in Barak valley. Structurally controlled fluvial erosion produced a series of cuesta ridges and strike valleys which were further subjected to erosional dissection leading to development of numerous topographic highs. Along the northern part of Barak valley adjoining Barail range, three terrace levels stand out with topographic offsets of upto ~10 m. These terraces are linked to tectonic adjustments along Haflong-Disang Thrust that traverse along the Barail foothills. Numerous wetlands linked to fluvial activities and also isolated from the fluvial domain form a significant element of the Barak valley landscape. Some of these wetlands have their origin to tectonic activities of the region. While the trunk channel of the region follows a nearly E-W trend, all the major tributaries join it at nearly orthogonal position following the prevailing structural trend.
Three coins in a fountain
Authors: Moffatt H. K. 
Published: March 2013

AbstractIf, in a large expanse of fluid such as air or water, an object that is heavier than the fluid displaced is released from rest, it descends in a manner that can depend in a complex way on its geometry and density (relative to that of the fluid), and on the fluid viscosity, which, as in other fluid contexts, remains important no matter how small this viscosity may be. A major numerical attack on this problem for the case in which the object is a thin circular disc is presented by Auguste, Magnaudet & Fabre (J. Fluid Mech., vol. 719, 2013, pp. 388–405).