bluuebunny/crossref_metadata_2025_split huggingface dataset:
X-ray diffraction study and powder patterns of double-perovskites Sr2RSbO6 (R = Pr, Nd, Sm, Eu, Gd, Dy, Ho, Y, Er, Tm, Yb, and Lu)
Authors: Wong-Ng W. , Kaduk J. A. , Luong M. , Huang Q. 
Published: September 2014

The X-ray diffraction powder patterns were prepared and the crystal structures were refined for the double-perovskite series of compounds, Sr2RSbO6 (R = Pr, Nd, Sm, Eu, Gd, Dy, Ho, Y, Er, Tm, Yb, and Lu). We found the structures of the entire Sr2RSbO6 series to be monoclinic with space group P21/n (no. 14), and Z = 2. From R = Lu to Pr, the lattice parameters “a” range from 5.7779(2) to 5.879 05(8) Å, “b” range from 5.7888(2) to 5.969 52(9) Å, “c” range from 8.1767(3) to 8.369 20(12) Å, “β” range from 90.112(2)° to 90.313(1)°, and “V” range from 273.483(4) to 293.714(7) Å3. These lattice parameters follow the well-established trend of “lanthanide contraction”. The R3+ and Sb5+ ions are found to be fully ordered in the double-perovskite arrangement of alternating corner-sharing octahedra in a zigzag fashion. The SrO12, RO6, and SbO6 cages are all found to have distorted coordination environments. Powder diffraction patterns of these compounds have been prepared, submitted, and published in the Powder Diffraction File.
Differential susceptibility to effects of maternal sensitivity? A study of candidate plasticity genes
Authors: Belsky Jay , Newman Daniel A. , Widaman Keith F. , Rodkin Phil , Pluess Michael , Fraley R. Chris , Berry Daniel , Helm Jonathan L. , Roisman Glenn I. 
Published: September 2014

AbstractHere we tested whether there was genetic moderation of effects of early maternal sensitivity on social–emotional and cognitive–linguistic development from early childhood onward and whether any detected Gene × Environment interaction effects proved consistent with differential-susceptibility or diathesis–stress models of Person × Environment interaction (N= 695). Two new approaches for evaluating models were employed with 12 candidate genes. Whereas maternal sensitivity proved to be a consistent predictor of child functioning across the primary-school years, candidate genes did not show many main effects, nor did they tend to interact with maternal sensitivity/insensitivity. These findings suggest that the developmental benefits of early sensitive mothering and the costs of insensitive mothering look more similar than different across genetically different children in the current sample. Although acknowledgement of this result is important, it is equally important that the generally null Gene × Environment results reported here not be overgeneralized to other samples, other predictors, other outcomes, and other candidate genes.
Cognitive Rehabilitation Multi-family Group Intervention for Individuals with Mild Cognitive Impairment and Their Care-Partners
Authors: Schmitter-Edgecombe Maureen , Dyck Dennis G. 
Published: September 2014

AbstractThere is increasing need for early, pro-active programs that can delay dementia diagnosis and enhance well-being of individuals with mild cognitive impairment (MCI) and their care-partners (i.e., care-dyads). This randomized controlled trial evaluated the efficacy of a combined cognitive rehabilitation and multi-family group treatment (CR-MFG) that was designed to facilitate adoption of newly learned cognitive strategies into the care-dyads everyday lives. Analyzed data included 23 care-dyads who participated in CR-MFG treatment and 23 care-dyads in standard care (SC). The 3-month intervention consisted of individual joining sessions, an educational workshop, and 20/twice weekly multifamily memory strategy training and problem-solving sessions. Everyday functioning, memory, and psychological functioning (i.e., quality-of-life, depression, coping) were assessed. The CR-MFG intervention was associated with significant post-test group differences and improved post-test performances by the MCI participants on performance-based measures of everyday functioning and neuropsychological tests of memory. There was also some suggestion that CR-MFG care-partners perceived positive change in the everyday functioning of the MCI participants. In contrast, no post-test group differences were found for either care-dyad member on the self-report psychological measures; care-partners in the treatment group did self-report improved coping behaviors at post-test. These 3-month results are preliminary but suggestive that CR-MFG may produce modest, practical everyday functional benefits for persons with MCI. (JINS, 2014, 20, 1–12)
The aetiology of anaemia during pregnancy: a study to evaluate the contribution of iron deficiency and common infections in pregnant Ugandan women
Authors: Baingana Rhona K , Enyaru John K , Tjalsma Harold , Swinkels Dorine W , Davidsson Lena 
Published: September 2014

AbstractObjectiveTo describe the aetiology of anaemia in pregnant Ugandan women and explore Fe deficiency and common infections as contributors to anaemia in this population.DesignCross-sectional study in which Hb, ferritin, transferrin receptor (sTfR), C-reactive protein, α-1 acid glycoprotein, hepcidin, malaria, hookworm infestation, syphilis andHelicobacter pyloriinfection were assessed.SettingAntenatal care clinic at Kawempe Health Centre, Kampala, Uganda.SubjectsHIV-negative women (n151) in their first or second pregnancy at 10–16 weeks’ gestation.ResultsThe prevalence of anaemia was 29·1 %. Fe deficiency was 40·4 % and 14·6 % based on ferritin <30 μg/l and on adjusted ferritin <12 μg/l respectively, and 6·6 % based on sTfR >8·3 μg/ml. The prevalence of Fe-deficiency anaemia was 9·3 % based on ferritin <30 μg/l, 6·6 % based on adjusted ferritin <12 μg/l and 4·3 % based on sTfR >8·3 μg/ml. Hepcidin concentration was positively correlated with ferritin concentration (n151,r=0·578,P<0·00001).H. pyloriinfection was highly prevalent (70 %) while malaria, hookworm infestation and syphilis were not common. Of all women, 60·3 % had α-1 acid glycoprotein >1 g/l and/or C-reactive protein >5 mg/l. Malaria parasitaemia (OR=6·85; 95 % CI 1·25, 37·41,P=0·026) and Fe deficiency defined using sTfR (OR=5·58; 95 % CI 1·26, 24·80,P=0·024) were independently and positively associated with anaemia. Population-attributable risk factors for anaemia for raised C-reactive protein, Fe deficiency defined by sTfR >8·3 μg/ml and presence of malaria parasites were 41·6 (95 % CI 11·1, 72·2) %, 13·5 (95 % CI 2·0, 25·0) % and 12·0 (95 % CI 1·4, 22·6) %, respectively.ConclusionsInfections and inflammation are of greater significance than Fe deficiency in the aetiology of anaemia in pregnant Ugandan women during the first trimester.
Changes in beverage consumption from pre-pregnancy to early pregnancy in the Norwegian Fit for Delivery study
Authors: Skreden Marianne , Bere Elling , Sagedal Linda R , Vistad Ingvild , Øverby Nina C 
Published: September 2014

AbstractObjectiveTo describe changes in consumption of different types of beverages from pre-pregnancy to early pregnancy, and to examine associations with maternal age, educational level and BMI.DesignCross-sectional design. Participants answered an FFQ at inclusion into a randomized controlled trial, the Fit for Delivery (FFD) trial, in median gestational week 15 (range: 9–20), reporting current consumption and in retrospect how often they drank the different beverages pre-pregnancy.SettingEight local antenatal clinics in southern Norway from September 2009 to February 2013.SubjectsFive hundred and seventy-five healthy pregnant nulliparous women.ResultsPre-pregnancy, 27 % reported drinking alcohol at least once weekly, compared with none in early pregnancy (P<0·001). The percentage of women drinking coffee (38 %v. 10 %,P<0·001), sugar-sweetened beverages (10 %v. 6 %,P=0·011) and artificially sweetened beverages (12 %v. 9 %,P=0·001) at least daily decreased significantly from pre-pregnancy to early pregnancy, while the percentage of women who reported to drink water (85 %v. 92 %,P<0·001), fruit juice (14 %v. 20 %,P=0·001) and milk (37 %v. 42 %,P=0·001) at least daily increased significantly. From pre-pregnancy to early pregnancy higher educated women reduced their consumption frequency of coffee significantly more than women with lower education. Older women reduced their consumption frequency of coffee and artificially sweetened beverages and increased their consumption frequency of fruit juice and milk significantly more than younger women.ConclusionsThere is a significant change in beverage consumption from pre-pregnancy to early pregnancy among Norwegian nulliparous women.
Body composition indices of a load–capacity model: gender- and BMI-specific reference curves
Authors: Siervo Mario , Prado Carla M , Mire Emily , Broyles Stephanie , Wells Jonathan CK , Heymsfield Steven , Katzmarzyk Peter T 
Published: September 2014

AbstractObjectiveFat mass (FM) and fat-free mass (FFM) are frequently measured to define body composition phenotypes. The load–capacity model integrates the effects of both FM and FFM to improve disease-risk prediction. We aimed to derive age-, gender- and BMI-specific reference curves of load–capacity model indices in an adult population (≥18 years).DesignCross-sectional study. Dual-energy X-ray absorptiometry was used to measure FM, FFM, appendicular skeletal muscle mass (ASM) and truncal fat mass (TrFM). Two metabolic load–capacity indices were calculated: ratio of FM (kg) to FFM (kg) and ratio of TrFM (kg) to ASM (kg). Age-standardised reference curves, stratified by gender and BMI (<25·0 kg/m2, 25·0–29·9 kg/m2, ≥30·0 kg/m2), were constructed using an LMS approach. Percentiles of the reference curves were 5th, 15th, 25th, 50th, 75th, 85th and 95th.SettingSecondary analysis of data from the 1999–2004 National Health and Nutrition Examination Survey (NHANES).SubjectsThe population included 6580 females and 6656 males.ResultsThe unweighted proportions of obesity in males and females were 25·5 % and 34·7 %, respectively. The average values of both FM:FFM and TrFM:ASM were greater in female and obese subjects. Gender and BMI influenced the shape of the association of age with FM:FFM and TrFM:ASM, as a curvilinear relationship was observed in female and obese subjects. Menopause appeared to modify the steepness of the reference curves of both indices.ConclusionsThis is a novel risk-stratification approach integrating the effects of high adiposity and low muscle mass which may be particularly useful to identify cases of sarcopenic obesity and improve disease-risk prediction.
Metabolic differences in ripening of Solanum lycopersicum ‘Ailsa Craig’ and three monogenic mutants
Authors: Beisken Stephan , Earll Mark , Baxter Charles , Portwood David , Ament Zsuzsanna , Kende Aniko , Hodgman Charlie , Seymour Graham , Smith Rebecca , Fraser Paul , Seymour Mark , Salek Reza M. , Steinbeck Christoph 
Published: September 2014

AbstractApplication of mass spectrometry enables the detection of metabolic differences between groups of related organisms. Differences in the metabolic fingerprints of wild-type Solanum lycopersicum and three monogenic mutants, ripening inhibitor (rin), non-ripening (nor) and Colourless non-ripening (Cnr), of tomato are captured with regard to ripening behaviour. A high-resolution tandem mass spectrometry system coupled to liquid chromatography produced a time series of the ripening behaviour at discrete intervals with a focus on changes post-anthesis. Internal standards and quality controls were used to ensure system stability. The raw data of the samples and reference compounds including study protocols have been deposited in the open metabolomics database MetaboLights via the metadata annotation tool Isatab to enable efficient re-use of the datasets, such as in metabolomics cross-study comparisons or data fusion exercises.
A repository of assays to quantify 10,000 human proteins by SWATH-MS
Authors: Rosenberger George , Koh Ching Chiek , Guo Tiannan , Röst Hannes L. , Kouvonen Petri , Collins Ben C. , Heusel Moritz , Liu Yansheng , Caron Etienne , Vichalkovski Anton , Faini Marco , Schubert Olga T. , Faridi Pouya , Ebhardt H. Alexander , Matondo Mariette , Lam Henry , Bader Samuel L. , Campbell David S. , Deutsch Eric W. , Moritz Robert L. , Tate Stephen , Aebersold Ruedi 
Published: September 2014

AbstractMass spectrometry is the method of choice for deep and reliable exploration of the (human) proteome. Targeted mass spectrometry reliably detects and quantifies pre-determined sets of proteins in a complex biological matrix and is used in studies that rely on the quantitatively accurate and reproducible measurement of proteins across multiple samples. It requires the one-time, a priori generation of a specific measurement assay for each targeted protein. SWATH-MS is a mass spectrometric method that combines data-independent acquisition (DIA) and targeted data analysis and vastly extends the throughput of proteins that can be targeted in a sample compared to selected reaction monitoring (SRM). Here we present a compendium of highly specific assays covering more than 10,000 human proteins and enabling their targeted analysis in SWATH-MS datasets acquired from research or clinical specimens. This resource supports the confident detection and quantification of 50.9% of all human proteins annotated by UniProtKB/Swiss-Prot and is therefore expected to find wide application in basic and clinical research. Data are available via ProteomeXchange (PXD000953-954) and SWATHAtlas (SAL00016-35).
Vascular calcification is coupled with phenotypic conversion of vascular smooth muscle cells through Klf5-mediated transactivation of the Runx2 promoter
Authors: Zhang Jing , Zheng Bin , Zhou Pei-pei , Zhang Ruo-Nan , He Ming , Yang Zhan , Wen Jin-Kun 
Published: September 2014

Both Klf5 (Krüppel-like factor 5) and Runx2 are involved in phenotypic switching of VSMC (vascular smooth muscle cells). However, the potential link between Klf5 and Runx2 in mediating vascular calcification remains unclear. The aim of the present study was to elucidate the actual relationship between Klf5 and Runx2 in mediating VSMC calcification. We found that high Pi (phosphate) increased the expression of Klf5, which is accompanied by loss of SM α-actin and SM22α (smooth muscle 22 α), as well as gain of Runx2 expression. Overexpression of Klf5 increased, while knockdown of Klf5 decreased, Runx2 expression and calcification. Further study showed that Klf5 bound directly to the Runx2 promoter and activated its transcription. Klf5 was also induced markedly in the calcified aorta of adenine-induced uremic rats. In conclusion, we demonstrate a critical role for Klf5-mediated induction of Runx2 in high Pi -induced VSMC calcification.
Synthetic Cannabinoids: Use and Predictors in a Community Sample of Young Adults
Authors: Caviness Celeste M. , Tzilos Golfo , Anderson Bradley J. , Stein Michael D. 
Published: September 2014

Background Synthetic cannabinoids (SCs) are a class of drugs of abuse with deleterious consequences. Despite governmental regulations related to distribution and sale, SC variants are still available online. More research is needed to determine SC use prevalence and factors associated with SC use, especially among young adults. Methods One thousand eighty individuals, 18–25 years old, were surveyed, between January 2012 and July 2013, during recruitment for a randomized controlled trial investigating health behaviors in young adults. Advertisements were placed online and in community locations seeking individuals “who had recently used marijuana or alcohol.” Respondents were queried about their use of alcohol and drugs, including SCs, in the last month. Results Participants averaged 21.4 years old and were 53.4% male. Nearly 59% were non-Hispanic white, 15% were African American, 15% were Hispanic, and 11% identified as other. Approximately 9% reported SC use in the last month, a level higher than the reported use of opioids, cocaine, or hallucinogens. SC use was significantly associated with male gender, not being enrolled in school, and with use of cigarettes, binge alcohol drinking, daily and weekly marijuana use, and other drugs of abuse. There was a significant decrease in SC use after the federal ban in July 2012. Conclusions SC use was common in the past month and often overlaps with other drug use, particularly marijuana use, and should be asked about during clinical encounters with young adults.
Comorbid Addiction and Major Mental Illness in Europe: A Narrative Review
Authors: Carrà Giuseppe , Bartoli Francesco , Brambilla Giulia , Crocamo Cristina , Clerici Massimo 
Published: September 2014

Background Most evidence about comorbid addiction and major mental illness comes from the USA, since this literature remains relatively limited in many European countries. The purpose of this review was to examine prevalence, policies, and treatment systems of comorbid substance misuse and psychotic illness in Europe, illustrating differences and similarities with US findings. Methods Based on computerized main databases searches, a narrative review was performed. Results The availability of substances but also the social contexts in terms of individual and local issues are factors likely to explain different dual diagnosis prevalence rates in Europe as compared with the USA. Conclusions Integrated models implemented following US example might perform differently within the context of well-established European Union (EU) community mental health services. Such programs would require additional resources and radical redesign of service delivery systems.
A contribution to the validation of the Wii Balance Board for the assessment of standing balance
Authors: Pavan Piero , Cardaioli Matteo , Ferri Ilaria , Gobbi Erica , Carraro Attilio 
Published: September 2014

AbstractValid and reliable accessible measures of balance are required in a health‐related fitness test battery, both in the general population and in groups with special needs. For this purpose, the capability of the Wii Balance Board (WBB) in evaluating standing balance was analysed and compared with a laboratory‐graded force platform (FP). A 30‐s double limb standing test with open and closed eyes was performed by 28 individuals (12 male and 16 female, mean age = 23.8, SD = ±2.7 years). A simple method of acquisition of the centre of pressure (CoP) over time was applied to compare WBB and FP simultaneously on the same signal. User‐defined software was developed to obtain the CoP from WBB over time and the resulting related measures and graphical representations. The comparison of measures, such as sway path and maximum oscillations along the anterior–posterior and medial–lateral direction, obtained with the FP and the WBB shows that the latter, in conjunction with the user‐defined developed software, can be appropriate, considering prescribed limits, and an easy‐to‐use tool for evaluating standing balance.
Variation of Seed Mineral Concentrations in Seven Quinoa Cultivars Grown in Two Agroecological Sites
Authors: Prado Fernando E. , Fernández‐Turiel José L. , Tsarouchi Martha , Psaras George K. , González Juan A. 
Published: September 2014

ABSTRACTVariations in concentration and tissue distribution of mineral elements in seeds of seven quinoa cultivars from both a “natural” habitat (Patacamaya, Bolivia, 3,960 m above sea level) and a “nonnatural” habitat (Encalilla, Argentina, 1,980 m above sea level) were analyzed. Data clearly showed inter‐ and intravarietal differences in seed mineral concentrations between the two sites. Correlation analysis revealed that concentrations of major and minor dietary minerals as well as essential ultratrace elements of Encalilla seeds showed, in general, higher correlations with both seed protein and seed yield than did element concentrations of Patacamaya seeds. Results of scanning electron microscopy combined with energy dispersive X‐ray spectroscopy showed clearly differences in the contents of major mineral elements (calcium, magnesium, potassium, phosphorus, and sulfur) in the pericarp and embryonic axis (cotyledon + radicle). Obtained data could indicate that genotype × environment interactions are responsible for mineral variations occurring in quinoa cultivars. Results can also be useful for developing mineral biofortification strategies for the world's poorest regions.
Suitability of Ontario‐Grown Hard and Soft Wheat Flour Blends for Noodle Making
Authors: Lu Zhanhui , Seetharaman Koushik 
Published: September 2014

ABSTRACTThis study evaluated the blending of flours made from an Ontario hard red winter wheat (HWF) and an Ontario soft red winter wheat (SWF) and compared it with a commercial standard noodle flour (control) made from Canadian Western Hard Red Spring wheat to assess the impact on white salted noodle‐making performance and texture of cooked noodles. Flour characteristics, gluten aggregation, and starch pasting properties were assessed with a farinograph, GlutoPeak tester, and Rapid Visco Analyzer, respectively. The machinability of dough was evaluated with an SMS/Kieffer rig attached to a TA.XT Plus texture analyzer. Tensile and bite tests of cooked noodles were also conducted. Blending HWF with standard noodle flour decreased gluten strength and dough extensibility linearly proportional to the blend ratio, whereas a curvilinear response from blending SWF with standard noodle flour was observed. HWF demonstrated more favorable pasting properties except for lower peak viscosity for noodle making than standard noodle flour. Below a 20% blend ratio with HWF, no significant changes were seen on dough extensibility, cooking loss, tensile properties, and bite testing parameters of cooked noodles. It can be concluded that blending HWF up to a 20% level caused no significant change in the processing properties of dough and cooked noodle quality. The results also showed that the GlutoPeak tester is a sensitive tool for evaluating gluten strength in wheat flour.