bluuebunny/crossref_metadata_2025_split huggingface dataset:
Economic models as devices of policy change: Policy paradigms, paradigm shift, and performativity
Authors: Henriksen Lasse F. 
Published: August 2013

AbstractCan the emergence of a new policy model be a catalyst for a paradigm shift in the overall interpretative framework of how economic policy is conducted within a society? This paper claims that models are understudied as devices used by actors to induce policy change. This paper explores the role of models in Danish economic policy, where, from the 1970s onwards, executive public servants in this area have exclusively been specialists in model design. To understand changes in economic policy, this paper starts with a discussion of whether the notion of paradigm shift is adequate. It then examines the extent to which the performativity approach can help identify macroscopic changes in policy from seemingly microscopic changes in policy models. The concept of performativity is explored as a means of thinking about the constitution of agency directed at policy change. The paper brings this concept into play by arguing that the “performative” embedding of models in institutions is an important aspect of how paradigm shifts unfold that the current literature has neglected.
Confronting trade‐offs and interactive effects in the choice of policy focus: Specialized versus comprehensive private governance
Authors: Auld Graeme 
Published: August 2013

AbstractIn setting standards for responsible business practices, certification programs create issue boundaries delineated by the focus of their standards. These issue boundaries may impede action on certain causes of problems (i.e. problem interactive effects) or lead to policy actions that affect other governance initiatives (i.e. policy interactive effects). When these interactions are extensive, programs confront trade‐offs: develop as a comprehensive program (i.e. have a broad policy focus) and take on higher internal administrative costs, or develop as a specialized program (i.e. have a narrow policy focus) and undertake to develop mechanisms to facilitate across‐program coordination. This paper explores these trade‐offs. It examines the origins of the different policy foci of coffee, forest, and fisheries certification programs, and identifies five strategies that programs are currently using to manage policy and/or problem interactive effects. Then, informed by research in public administration and international relations, it details additional approaches for improving issue‐boundary management.
Vinorelbine rescue therapy for dogs with primary urinary bladder carcinoma
Authors: Kaye M. E. , Thamm D. H. , Weishaar K. , Lawrence J. A. 
Published: August 2013

AbstractThe goal of this study was to evaluate the anti‐tumour activity and toxicoses of vinorelbine as a palliative rescue therapy for dogs with primary urinary bladder carcinoma. Thirteen dogs refractory to prior chemotherapeutics and one dog naïve to chemotherapeutic treatment were enrolled. Vinorelbine (15 mg m−2IV) was administered intravenously along with concurrent oral anti‐inflammatory drugs, if tolerated. A median of six doses of vinorelbine (range: 1–16) was administered. Two dogs (14%) had partial responses, and eight (57%) experienced stable disease. Subjective improvement in clinical signs was noted in 11 dogs (78%). Adverse events were mild and primarily haematological in nature. Median time to progression was 93 days (range: 20–239 days). Median survival time for all dogs was 187 days; median survival for 13 pre‐treated dogs was 207 days. Vinorelbine may have utility in the management of canine primary urinary bladder carcinoma and should be evaluated in a prospective study.
Impact of site conditions and farming practices on the occurrence of rare and endangered weeds on arable land in the Czech Republic
Authors: Kolářová M , Tyšer L , Soukup J 
Published: August 2013

SummaryThis article documents the impact of site conditions and farming practices on the occurrence of rare and endangered weeds on arable land in the Czech Republic. A survey was conducted between 2006 and 2008 in winter cereals, spring cereals and wide‐row crops. The relationship between the occurrence of plants and explanatory factors was analysed using a multivariate analysis to calculate species frequencies in different types of farming, crops and altitudes. In total, 290 relevés were recorded, with a total number of 172 weed species. Nineteen weeds, classified as rare and endangered species according to the national Czech list, were identified in 106 relevés. The highest effect on the occurrence of rare and endangered weed species was observed for altitude. Almost half of the recorded endangered and rare species belonged to the thermophilous weed vegetation typical for cereals on basic soils. A higher occurrence of endangered species has been confirmed for organic farming, where the sum of frequencies was 4.5 times higher than in conventional farming. Field size was not included in our analyses, but could be a factor affecting weed assemblages. The highest frequency of rare species was recorded in spring cereals, followed by winter cereals and wide‐row crops. Higher numbers were identified within fields with higher weed coverage. Lower farming intensity and diversified farming systems at higher altitudes provided better conditions for the occurrence of rare species than intensively farmed lowlands.
A parameterization method and application in breast tomosynthesis dosimetry
Authors: Li Xinhua , Zhang Da , Liu Bob 
Published: August 2013

Purpose:To present a parameterization method based on singular value decomposition (SVD), and to provide analytical parameterization of the mean glandular dose (MGD) conversion factors from eight references for evaluating breast tomosynthesis dose in the Mammography Quality Standards Act (MQSA) protocol and in the UK, European, and IAEA dosimetry protocols.Methods:MGD conversion factor is usually listed in lookup tables for the factors such as beam quality, breast thickness, breast glandularity, and projection angle. The authors analyzed multiple sets of MGD conversion factors from the Hologic Selenia Dimensions quality control manual and seven previous papers. Each data set was parameterized using a one‐ to three‐dimensional polynomial function of 2–16 terms. Variable substitution was used to improve accuracy. A least‐squares fit was conducted using the SVD.Results:The differences between the originally tabulated MGD conversion factors and the results computed using the parameterization algorithms were (a) 0.08%–0.18% on average and 1.31% maximum for the Selenia Dimensions quality control manual, (b) 0.09%–0.66% on average and 2.97% maximum for the published data by Dance et al. [Phys. Med. Biol. 35, – (1990) 10.1088/0031‐9155/35/9/002; Dance et al. Phys. Med. Biol. 45, 3225–3240 (2000) 10.1088/0031‐9155/45/11/308; Dance et al. Phys. Med. Biol. 54, 4361–4372 (2009) 10.1088/0031‐9155/54/14/002; Dance et al. Phys. Med. Biol. 56, 453–471 (2011)] 10.1088/0031‐9155/56/2/011, (c) 0.74%–0.99% on average and 3.94% maximum for the published data by Sechopoulos et al. [Med. Phys. 34, 221–232 (2007)10.1118/1.2400836; Sechopoulos et al. J. Appl. Clin. Med. Phys. 9, 161–171 (2008)] 10.1120/jacmp.v9i4.2887, and (d) 0.66%–1.33% on average and 2.72% maximum for the published data by Feng and Sechopoulos [Radiology 263, 35–42 (2012)] 10.1148/radiol.11111789, excluding one sample in (d) that does not follow the trends in the published data table.Conclusions:A flexible parameterization method is presented in this paper, and was applied to breast tomosynthesis dosimetry. The resultant data offer easy and accurate computations of MGD conversion factors for evaluating mean glandular breast dose in the MQSA protocol and in the UK, European, and IAEA dosimetry protocols. Microsoft Excel™ spreadsheets are provided for the convenience of readers.
Real‐time soft tissue motion estimation for lung tumors during radiotherapy delivery
Authors: Rottmann Joerg , Keall Paul , Berbeco Ross 
Published: August 2013

Purpose:To provide real‐time lung tumor motion estimation during radiotherapy treatment delivery without the need for implanted fiducial markers or additional imaging dose to the patient.Methods:2D radiographs from the therapy beam's‐eye‐view (BEV) perspective are captured at a frame rate of 12.8 Hz with a frame grabber allowing direct RAM access to the image buffer. An in‐house developed real‐time soft tissue localization algorithm is utilized to calculate soft tissue displacement from these images in real‐time. The system is tested with a Varian TX linear accelerator and an AS‐1000 amorphous silicon electronic portal imaging device operating at a resolution of 512 × 384 pixels. The accuracy of the motion estimation is verified with a dynamic motion phantom. Clinical accuracy was tested on lung SBRT images acquired at 2 fps.Results:Real‐time lung tumor motion estimation from BEV images without fiducial markers is successfully demonstrated. For the phantom study, a mean tracking error <1.0 mm [root mean square (rms) error of 0.3 mm] was observed. The tracking rms accuracy on BEV images from a lung SBRT patient (≈20 mm tumor motion range) is 1.0 mm.Conclusions:The authors demonstrate for the first time real‐time markerless lung tumor motion estimation from BEV images alone. The described system can operate at a frame rate of 12.8 Hz and does not require prior knowledge to establish traceable landmarks for tracking on the fly. The authors show that the geometric accuracy is similar to (or better than) previously published markerless algorithms not operating in real‐time.
Total target volume is a better predictor of whole brain dose from gamma stereotactic radiosurgery than the number, shape, or location of the lesions
Authors: Narayanasamy Ganesh , Smith Adam , Van Meter Emily , McGarry Ronald , Molloy Janelle A. 
Published: August 2013

Purpose:To assess the hypothesis that the volume of whole brain that receives a certain dose level is primarily dependent on the treated volume rather than on the number, shape, or location of the lesions. This would help a physician validate the suitability of GammaKnife® based stereotactic radiosurgery (GKSR) prior to treatment.Methods:Simulation studies were performed to establish the hypothesis for both oblong and spherical shaped lesions of various numbers and sizes. Forty patients who underwent GKSR [mean age of 54 years (range 7–80), mean number of lesions of 2.5 (range 1–6), and mean lesion volume of 4.4 cm3 (range 0.02–22.2 cm3)] were also studied retrospectively. Following recommendations of QUANTEC, the volume of brain irradiated by the 12 Gy (VB12) isodose line was measured and a power‐law based relation is proposed here for estimating VB12 from the known tumor volume and the prescription dose.Results:In the simulation study on oblong, spherical, and multiple lesions, the volume of brain irradiated by 50%, 10%, and 1% of maximum dose was found to have linear, linear, and exponentially increasing dependence on the volume of the treated region, respectively. In the retrospective study on 40 GKSR patients, a similar relationship was found to predict the brain dose with a Spearman correlation coefficient >0.9. In both the studies, the volume of brain irradiated by a certain dose level does not have a statistically significant relationship (p ≥ 0.05) with the number, shape, or position of the lesions. The measured VB12 agrees with calculation to within 1.7%.Conclusions:The results from the simulation and the retrospective clinical studies indicate that the volume of whole brain that receives a certain percentage of the maximum dose is primarily dependent on the treated volume and less on the number, shape, and location of the lesions.
Latent Heating and Mixing due to Entrainment in Tropical Deep Convection
Authors: McGee Clayton J. , van den Heever Susan C. 
Published: August 2013

Abstract
Recent studies have noted the role of latent heating above the freezing level in reconciling Riehl and Malkus' hot tower hypothesis (HTH) with evidence of diluted tropical deep convective cores. This study evaluates recent modifications to the HTH through Lagrangian trajectory analysis of deep convective cores in an idealized, high-resolution cloud-resolving model (CRM) simulation that uses a sophisticated two-moment microphysical scheme. A line of tropical convective cells develops within a finer nested grid whose boundary conditions are obtained from a large-domain CRM simulation approaching radiative convective equilibrium (RCE). Microphysical impacts on latent heating and equivalent potential temperature (θe) are analyzed along trajectories ascending within convective regions of the high-resolution nested grid. Changes in θe along backward trajectories are partitioned into contributions from latent heating due to ice processes and a residual term that is shown to be an approximate representation of mixing. The simulations demonstrate that mixing with dry environmental air decreases θe along ascending trajectories below the freezing level, while latent heating due to freezing and vapor deposition increase θe above the freezing level. Latent heating contributions along trajectories from cloud nucleation, condensation, evaporation, freezing, deposition, and sublimation are also quantified. Finally, the source regions of trajectories reaching the upper troposphere are identified. Much of the air ascending within convective updrafts originates from above the lowest 2 km AGL, but the strongest updrafts are composed of air from closer to the surface. The importance of both boundary layer and midlevel inflow in moist environments is underscored in this study.
Impact of Northward-Propagating Intraseasonal Variability on the Onset of Indian Summer Monsoon
Authors: Zhou Lei , Murtugudde Raghu 
Published: August 2013

Abstract
The onset of the Indian summer monsoon (ISM) has a pronounced interannual variability, part of which originates from the large-scale circulation and its thermodynamic properties. While the northward-propagating intraseasonal variabilities (ISVs) are a prominent characteristic of the ISM, they tend to initiate an early onset by transferring moisture and momentum from the deep tropics to the Indian subcontinent. However, not all early onsets of ISM are attributable to strong ISVs and not all strong ISVs can lead to early ISM onsets. With a daily Indian monsoon index and a simple regression model, the onsets of ISM from 1982 to 2011 are separated into two groups. The years in which the early onsets of ISM are closely related to the northward-propagating ISVs are categorized as the ISVO years, and the other years in which the ISM onsets are not closely related to ISVs are categorized as non-ISVO years. The former category is the focus of this study. Before the onset of ISM in the ISVO years, the convective features are prominent, such as a cyclone over the Bay of Bengal (BoB) and the associated strong convection. The ocean–atmosphere interaction is found to be important for the northward-propagating ISVs before the ISM onset in the ISVO years. Evidence shows that warm SST anomalies drive the atmosphere and lead to atmospheric instability and convection. This reinforces the more recent view that the ocean does not just play a passive role in the northward-propagating ISVs. This process understanding helps shape the path to enhancing predictive understanding and monsoon prediction skills with obvious implications for the prediction of El Niño–Southern Oscillation.
Principal Components of Multifrequency Microwave Land Surface Emissivities. Part II: Effects of Previous-Time Precipitation
Authors: You Yalei , Turk F. Joseph , Haddad Ziad S. , Li Li , Liu Guosheng 
Published: August 2013

Abstract
The microwave land surface emissivity (MLSE) over the continental United States was examined during 2011 as a function of prior rainfall conditions using two independent emissivity estimation techniques, one providing instantaneous estimates based on a clear-scene emissivity principal component (PC) analysis and the other based on physical radiative transfer modeling. Results show that over grass, closed shrub, and cropland, prior rainfall can cause the horizontally polarized 10-GHz brightness temperature (TB) to drop by as much as 20 K, with a corresponding emissivity drop of approximately 0.06, whereby prior rain exhibited little influence on the emissivity over forest because of the dense vegetation. The correlation between emissivity and its leading principal components and the prior rainfall over grass, closed shrub, and cropland is −0.6, while it is only −0.1 over forested areas. Forward-simulated TB using the PC-based emissivity derived from instantaneous Tropical Rainfall Measuring Mission (TRMM) satellite overpasses agrees much better with TRMM Microwave Imager (TMI) observations relative to a climatologically based emissivity, especially after a period of heavy rain. Two potential applications of the PC-based emissivity are demonstrated. The first exploits the time history change of the MLSE to estimate the amount of prior rainfall. The second application is a method to estimate the emissivity underneath precipitating radiometric scenes by first adjusting the surface-sensitive principal components that were derived under clear-sky scenes and then by reconstructing the joint emissivity (all channels simultaneously) from the modified PC structure. The results are applicable to future overland passive microwave rainfall retrieval algorithms to simultaneously detect and estimate precipitation amounts under dynamically changing surface conditions.
Development and evaluation of an intervention aiming to reduce fatigue in airline pilots: design of a randomised controlled trial
Authors: van Drongelen Alwin , van der Beek Allard J , Hlobil Hynek , Smid Tjabe , Boot Cécile RL 
Published: August 2013

Abstract

Background
A considerable percentage of flight crew reports to be fatigued regularly. This is partly caused by irregular and long working hours and the crossing of time zones. It has been shown that persistent fatigue can lead to health problems, impaired performance during work, and a decreased work-private life balance. It is hypothesized that an intervention consisting of tailored advice regarding exposure to daylight, optimising sleep, physical activity, and nutrition will lead to a reduction of fatigue in airline pilots compared to a control group, which receives a minimal intervention with standard available information.

Methods/design
The study population will consist of pilots of a large airline company. All pilots who posses a smartphone or tablet, and who are not on sick leave for more than four weeks at the moment of recruitment, will be eligible for participation.
In a two-armed randomised controlled trial, participants will be allocated to an intervention group that will receive the tailored advice to optimise exposure to daylight, sleep, physical activity and nutrition, and a control group that will receive standard available information. The intervention will be applied using a smartphone application and a website, and will be tailored on flight- and participant-specific characteristics. The primary outcome of the study is perceived fatigue. Secondary outcomes are need for recovery, duration and quality of sleep, dietary and physical activity behaviours, work-private life balance, general health, and sickness absence. A process evaluation will be conducted as well. Outcomes will be measured at baseline and at three and six months after baseline.

Discussion
This paper describes the development of an intervention for airline pilots, consisting of tailored advice (on exposure to daylight and sleep-, physical activity, and nutrition) applied into a smartphone application. Further, the paper describes the design of the randomised controlled trial evaluating the effect of the intervention on fatigue, health and sickness absence. If proven effective, the intervention can be applied as a new and practical tool in fatigue management. Results are expected at the end of 2013.

Trial registration
Netherlands Trial Register: NTR2722
Nutritional supplements for diabetes sold on the internet: business or health promotion?
Authors: Covolo Loredana , Capelli Michela , Ceretti Elisabetta , Feretti Donatella , Caimi Luigi , Gelatti Umberto 
Published: August 2013

Abstract

Background
Diabetes is one of the most widespread chronic disease. Although many medications are available for the treatment and prevention of diabetes, many people turn to nutritional supplements (NSs). In these years, the online sales have contributed to the growth of use of nutritional supplement. The aim of the research was to investigate the type of information provided by sales websites on NSs, and analyse the existence of scientific evidence about some of the most common ingredients found in available NSs for diabetes.

Methods
A web search was conducted in April 2012 to identify web sites selling NSs in the treatment of diabetes using Google, Yahoo and Bing! and the key word used was “diabetes nutritional supplements”. Website content was evaluated for the quality of information available to consumers and for the presence of a complete list of ingredients in the first NS suggested by the site. Subsequently, in order to analyze the scientific evidence on the efficacy of these supplements a PubMed search was carried out on the ingredients that were shared in at least 3 nutritional supplements.

Results
A total of 10 websites selling NSs were selected. Only half of the websites had a Food and Drug Administration disclaimer and 40% declared clearly that the NS offered was not a substitute for proper medication. A total of 10 NS ingredients were searched for on PubMed. Systematic reviews, meta-analyses or randomized control trials were present for all the ingredients except one. Most of the studies, however, were of poor quality and/or the results were conflicting.

Conclusions
Easy internet access to NSs lacking in adequate medical information and strong scientific evidence is a matter of public health concern, mainly considering that a misleading information could lead to an improper prevention both in healthy people and people suffering from diabetes. There is a clear need for more trials to assess the efficacy and safety of these NSs, better quality control of websites, more informed physicians and greater public awareness of these widely used products.