bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative efficacy and acceptability of psychotherapies for acute anxiety disorders in children and adolescents: study protocol for a network meta-analysis
Authors: Zhang Yuqing , Zhou Xinyu , James Anthony C , Qin Bin , Whittington Craig J , Cuijpers Pim , Del Giovane Cinzia , Liu Yiyun , Cohen David , Weisz John R , Xie Peng 
Published: October 2015

IntroductionAnxiety disorders are associated with significant public health burden in young individuals. Cognitive-behavioural therapy (CBT) is the most commonly used psychotherapy for anxiety disorders in children and adolescents, but previous reviews were hindered by a limited number of trials with direct comparisons between different psychotherapies and their deliveries. Consequently, the main aim of this research was to investigate the comparative efficacy and acceptability of various types and deliveries of psychotherapies for anxiety disorders in children and adolescents.Methods and analysisWe will systematically search PubMed, EMBASE, Cochrane, Web of Science, PsycINFO, CINAHL, ProQuest Dissertations and LiLACS for randomised controlled trials, regardless of whether participants received blinding or not, published from 1 January 1966 to 30 January 2015 (updated to 1 July 2015), that compared any psychotherapy with either a control condition or an active comparator with different types and/or different delivery formats for the acute treatment of anxiety disorders in children and adolescents. Data extraction, risk of bias and quality assessments will be independently extracted by two reviewers. The primary outcome for efficacy will be mean overall change scores in anxiety symptoms (self-rated or assessor-rated) from baseline to post-treatment between two groups. The acceptability of treatment will be measured as the proportion of patients who discontinued treatment during the acute phase of treatment. We will assess efficacy, based on the standardised mean difference (SMD), and acceptability, based on the OR, using a random-effects network meta-analysis within a Bayesian framework. Subgroup and sensitivity analyses will be conducted to assess the robustness of the findings.Ethics and disseminationNo ethical issues are foreseen. The results will be published in a peer-reviewed journal and will be disseminated electronically and in print. The meta-analysis may be updated to inform and guide management of anxiety in children and adolescents.Trial registration numberPROSPERO CRD42015016283.
Assessing the feasibility of screening and providing brief advice for alcohol misuse in general dental practice: a clustered randomised control trial protocol for the DART study
Authors: Ntouva Antiopi , Porter Jessie , Crawford Mike J , Britton Annie , Gratus Christine , Newton Tim , Tsakos Georgios , Heilmann Anja , Pikhart Hynek , Watt Richard G 
Published: October 2015

IntroductionAlcohol misuse is a significant public health problem with major health, social and economic consequences. Systematic reviews have reported that brief advice interventions delivered in various health service settings can reduce harmful drinking. Although the links between alcohol and oral health are well established and dentists come into contact with large numbers of otherwise healthy patients regularly, no studies have been conducted in the UK to test the feasibility of delivering brief advice about alcohol in general dental settings.Methods and analysisThe Dental Alcohol Reduction Trial (DART) aims to assess the feasibility and acceptability of screening for alcohol misuse and delivering brief advice in patients attending National Health Service (NHS) general dental practices in North London. DART is a cluster randomised control feasibility trial and uses a mixed methods approach throughout the development, design, delivery and evaluation of the intervention. It will be conducted in 12 NHS general dental practices across North London and will include dental patients who drink above the recommended guidance, as measured by the Alcohol Use Disorders Identification Test (AUDIT-C) screening tool. The intervention involves 5 min of tailored brief advice delivered by dental practitioners during the patient's appointment. Feasibility and acceptability measures as well as suitability of proposed primary outcomes of alcohol consumption will be assessed. Initial economic evaluation will be undertaken. Recruitment and retention rates as well as acceptability of the study procedures from screening to follow-up will be measured.Ethics and disseminationEthical approval was obtained from the Camden and Islington Research Ethics Committee. Study outputs will be disseminated via scientific publications, newsletters, reports and conference presentations to a range of professional and patient groups and stakeholders. Based on the results of the trial, recommendations will be made on the conduct of a definitive randomised controlled trial.Trial registration numberISRCTN81193263.
Longitudinal cohort study describing persistent frequent attenders in Australian primary healthcare
Authors: Pymont Carly , Butterworth Peter 
Published: October 2015

ObjectivesTo describe patterns of frequent attendance in Australian primary care, and identify the prospective risk factors for persistent frequent attendance.Design, setting and participantsThis study draws on data from the Personality and Total Health (PATH) Through Life Project, a representative community cohort study of residents from the Canberra region of Australia. Participants were assessed on 3 occasions over 8 years. The survey assessed respondents’ experience of chronic physical conditions, self-reported health, symptoms of common mental disorders, personality, life events, sociodemographic characteristics and self-reported medication use. A balanced sample was used in analysis, comprising 1734 respondents with 3 waves of data. The survey data for each respondent were individually linked to their administrative health service use data which were used to generate an objective measure of general practitioner (GP) consultations in the 12 months surrounding their interview date.Main outcome measuresRespondents in the (approximate) highest decile of attenders on number of GP consultations over a 12-month period at each time point were defined as frequent attenders (FAs).ResultsBaseline FAs (8.4%) were responsible for 33.4% of baseline consultations, while persistent FAs (3.6%) for 15.5% of all consultations over the 3 occasions. While there was considerable movement between FA status over time, consistency was greater than expected by chance alone. While there were many factors that differentiated non-FAs from FAs in general, persistent frequent attendance was specifically associated with gender, baseline reports of depression, self-reported physical conditions and disability, and medication use.ConclusionsThe degree of persistence in GP consultations was limited. The findings of this study contribute to our understanding of the risk factors that predict subsequent persistent frequent attendance in primary care. However, further detailed investigation of longitudinal patterns of frequent attendance and consideration of time-varying determinants of frequent attendance is required.
Genome-Wide Identification of a Methylation Gene Panel as a Prognostic Biomarker in Nasopharyngeal Carcinoma
Authors: Jiang Wei , Liu Na , Chen Xiao-Zhong , Sun Ying , Li Bin , Ren Xian-Yue , Qin Wei-Feng , Jiang Ning , Xu Ya-Fei , Li Ying-Qin , Ren Jian , Cho William CS , Yun Jing-Ping , Zeng Jing , Liu Li-Zhi , Li Li , Guo Ying , Mai Hai-Qiang , Zeng Mu-Sheng , Kang Tie-Bang , Jia Wei-Hua , Shao Jian-Yong , Ma Jun 
Published: October 2015

Abstract
DNA methylation, the best known epigenetic marker, can be used as a prognostic biomarker in many cancers. We examined DNA methylation status and survival in nasopharyngeal carcinoma (NPC) patients. Aberrant DNA-methylated genes in 24 NPC tissues and 24 noncancer nasopharyngitis biopsy tissues (NCNBT) were identified using Illumina 450K BeadChip. Correlations between DNA methylation and clinical outcomes were evaluated using bisulfite pyrosequencing in 454 NPC patients. Genome-wide methylation analysis demonstrated that NPC tissues had distinct DNA methylation patterns compared with NCNBT. Among all significant CpG sites, 2,173 CpG sites with β change ≥ 0.2 (1,880 hypermethylated, 293 hypomethylated) were identified (P &lt; 0.05). A methylation gene panel comprising six hypermethylated genes was constructed with the average Z-score method. Patients in the training cohort with high methylation had poorer disease-free survival [DFS, HR, 2.26; 95% confidence interval (CI), 1.28–4.01; P, 0.005] and overall survival (OS, HR, 2.47; 95% CI, 1.30–4.71; P, 0.006) than those with low methylation. There were similar results in the validation (DFS, HR, 2.07; 95% CI, 1.17–3.67; P, 0.013; OS, HR, 1.83; 95% CI, 1.01–3.31; P, 0.046) and independent cohorts (DFS, HR, 1.94; 95% CI, 1.08–3.47; P, 0.026; OS, HR, 2.09; 95% CI, 1.10–3.98; P, 0.022). Analysis indicated that the methylation gene panel was an independent prognostic factor. Furthermore, patients with low methylation had a favorable response to concurrent chemotherapy with an improved DFS (P = 0.045) and OS (P = 0.031), whereas patients with high methylation did not benefit from concurrent chemotherapy. The six–hypermethylated gene panel was associated with poor survival in patients with NPC, demonstrating its potential usefulness as a prognostic biomarker to clinicians in NPC management. Mol Cancer Ther; 14(12); 2864–73. ©2015 AACR.
Differences in Common Genetic Predisposition to Ischemic Stroke by Age and Sex
Authors: Traylor Matthew , Rutten-Jacobs Loes C.A. , Holliday Elizabeth G. , Malik Rainer , Sudlow Cathie , Rothwell Peter M. , Maguire Jane M. , Koblar Simon A. , Bevan Steve , Boncoraglio Giorgio , Dichgans Martin , Levi Chris , Lewis Cathryn M. , Markus Hugh S. 
Published: October 2015

Background and Purpose—
Evidence from epidemiological studies points to differences in factors predisposing to stroke by age and sex. Whether these arise because of different genetic influences remained untested. Here, we use data from 4 genome-wide association data sets to study the relationship between genetic influence on stroke with both age and sex.

Methods—
Using genomic-relatedness-matrix restricted maximum likelihood methods, we performed 4 analyses: (1) we calculated the genetic correlation between groups divided by age and (2) by sex, (3) we calculated the heritability of age-at-stroke-onset, and (4) we evaluated the evidence that heritability of stroke is greater in women than in men.

Results—

We found that genetic factors influence age at stroke onset (
h
2
[SE]=18.0 [6.8];
P
=0.0038), with a trend toward a stronger influence in women (women:
h
2
[SE]=21.6 [3.5]; Men:
h
2
[SE]=13.9 [2.8]). Although a moderate proportion of genetic factors was shared between sexes (
rG
[SE]=0.68 [0.16]) and between younger and older cases (
rG
[SE]=0.70 [0.17]), there was evidence to suggest that there are genetic susceptibility factors that are specific to sex (
P
=0.037) and to younger or older groups (
P
=0.056), particularly for women (
P
=0.0068). Finally, we found a trend toward higher heritability of stroke in women although this was not significantly greater than in men (
P
=0.084).

Conclusions—
Our results indicate that there are genetic factors that are either unique to or have a different effect between younger and older age groups and between women and men. Performing large, well-powered genome-wide association study analyses in these groups is likely to uncover further associations.
Nukuhiva Berland, 1935 is a troglobitic wolf spider (Araneae: Lycosidae), not a nursery-web spider (Pisauridae)
Authors: FRAMENAU VOLKER W. , LEHTINEN PEKKA T. 
Published: October 2015

The monotypic genus Nukuhiva Berland, 1935 with N. adamsoni (Berland, 1933) as type species, is re-described and transferred from the Pisauridae Simon, 1890 (fishing or nursery-web spiders) to the Lycosidae Sundevall, 1833 (wolf spiders) based on genitalic and somatic characters. Nukuhiva adamsoni, originally described from French Polynesia, appears to inhabit mountainous habitats of volcanic origin. Its troglobitic morphology—comparatively small eyes and pale, uniform coloration—suggest it to be associated with subterranean habitats such as caves or lava tubes, similar to the Hawaiian troglobitic species Lycosa howarthi Gertsch, 1973 and Adelocosa anops Gertsch, 1973.
Impact of Diabetes Mellitus on Head and Neck Cancer Patients Undergoing Surgery
Authors: Raikundalia Milap D. , Fang Christina H. , Spinazzi Eleonora F. , Vazquez Alejandro , Park Richard Chan , Baredes Soly , Eloy Jean Anderson 
Published: October 2015

ObjectiveThe impact of diabetes mellitus (DM) on surgical outcomes and cost of care for patients undergoing surgery for head and neck cancer (HNCA) is not well established. We used the Nationwide Inpatient Sample to analyze the postoperative impact of DM on HNCA patients.Study DesignPopulation‐based inpatient registry analysis.SettingAcademic medical center.Subjects and MethodsDischarge data from the Nationwide Inpatient Sample were analyzed for patients undergoing HNCA surgery from 2002 to 2010. Patient demographics, comorbidities, length of stay, hospital charges, and postoperative complications were compared between HNCA patients with and without DM.ResultsOf 31,075 patients, 4029 patients (13.0%) had a DM diagnosis. DM patients were older (65.7 ± 10.8 vs 61.1 ± 14.1 years old; P <. 001), had more preexisting comorbidities, had longer hospitalizations, and incurred greater hospital charges. Compared with the non‐DM cohort, DM patients experienced significantly higher rates of postoperative infections (2.6% vs 2.1%, P =. 025), cardiac events (9.0% vs 4.3%, P <. 001), pulmonary edema/failure (6.6% vs 5.7%, P =. 023), acute renal failure (3.3% vs 1.5%, P <. 001), and urinary tract infections (2.8 % vs 2.1%, P =. 005). No differences in surgical wound healing rates were observed (0.1 vs 0.1, P =. 794). On multivariate logistic regression corrected for age and race, DM patients had greater odds of postoperative infections (1.382, P =. 007), cardiac events (1.893, P <. 001), and acute renal failure (2.023, P <. 001).ConclusionsDM is associated with greater length of stay and hospital charges among HNCA patients. DM patients have significantly greater rates of postoperative complications, including postoperative infections, cardiac events, and acute renal failure.
slan-defined subsets of CD16-positive monocytes: impact of granulomatous inflammation and M-CSF receptor mutation
Authors: Hofer Thomas P. , Zawada Adam M. , Frankenberger Marion , Skokann Kerstin , Satzl Anna A. , Gesierich Wolfgang , Schuberth Madeleine , Levin Johannes , Danek Adrian , Rotter Björn , Heine Gunnar H. , Ziegler-Heitbrock Loems 
Published: October 2015

Key Points
The slan marker can be used to define nonclassical and intermediate monocytes in human blood. slan-negative intermediate monocytes are expanded in sarcoidosis, and slan-positive nonclassical monocytes are depleted in HDLS.
Intake of multivitamin supplements and incident asthma in Norwegian adults: the HUNT study
Authors: Jiang Lin , Brumpton Ben , Langhammer Arnulf , Chen Yue , Mai Xiao-Mei 
Published: October 2015

Although intake of multivitamin supplements is becoming increasingly popular, the relationship between intake of multivitamin supplements and incident asthma remains unclear. Prospective studies in adults with long-term follow-up are especially scarce. Our objective was to investigate the association between intake of multivitamin supplements and asthma development in Norwegian adults.We followed 16 952 adult subjects from the second survey of the Nord-Trøndelag Health Study (1995–1997) up to 2006–2008, who, at baseline, were free of asthma and provided information on their intake of multivitamin supplements and cod liver oil. Regular intake of multivitamin supplements or cod liver oil was defined as daily intake for ≥3 months during the year prior to baseline. Incident asthma was defined as reported new-onset asthma after the 11-year follow-up.Intake of multivitamin supplements only was associated with an increased odds ratio for incident asthma (OR 1.55, 95% CI 1.12–2.13) after adjustment for a number of common confounding factors (model I). Similar odds ratios were found for intake of cod liver oil only and for intake of both supplements (1.59 and 1.73, respectively).Regular intake of multivitamin supplements was associated with an increased odds ratio for incident asthma in Norwegian adults.
Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells
Authors: Zhang Fengyun , Cui Jinjin , Liu Xiaojing , Lv Bo , Liu Xinxin , Xie Zulong , Yu Bo 
Published: October 2015

Abstract
Introduction
Mesenchymal stem cell (MSC)-based therapies have had positive outcomes both in animal models of cardiovascular diseases and in clinical patients. However, the number and function of MSCs decline during hypoxia and serum deprivation (H/SD), reducing their ability to contribute to endogenous injury repair. MicroRNA-34a (miR-34a) is originally identified as a TP53-targeted miRNA that modulates cell functions, including apoptosis, proliferation, and senescence via several signaling pathways, and hence is an appealing target for MSC-based therapy for myocardial infarction.

Methods
Bone marrow-derived MSCs were isolated from 60–80 g male donor rats. Expression levels of miR-34a were determined by qRT-PCR. The roles of miR-34a in regulating cell vitality, apoptosis and senescence were investigated using the cell counting kit (CCK-8) assay, flow cytometric analysis of Annexin V-FITC/PI staining and senescence-associated β-galactosidase (SA-β-gal) staining, respectively. The expression of silent information regulator 1 (SIRT1) and forkhead box class O 3a (FOXO3a) and of apoptosis- and senescence-associated proteins in MSCs were analyzed by western blotting.

Results
The results of the current study showed that miR-34a was significantly up-regulated under H/SD conditions in MSCs, while overexpression of miR-34a was significantly associated with increased apoptosis, impaired cell vitality and aggravated senescence. Moreover, we found that the mechanism underlying the proapoptotic function of miR-34a involves activation of the SIRT1/FOXO3a pathway, mitochondrial dysfunction and finally, activation of the intrinsic apoptosis pathway. Further study showed that miR-34a can also aggravate MSC senescence, an effect which was partly abolished by the reactive oxygen species (ROS) scavenger, N-acetylcysteine (NAC).

Conclusions
Our study demonstrates for the first time that miR-34a plays pro-apoptotic and pro-senescence roles in MSCs by targeting SIRT1. Thus, inhibition of miR-34a might have important therapeutic implications in MSC-based therapy for myocardial infarction.
The mud-sand crossover on marine seismic data
Authors: Cook Ann E. , Sawyer Derek E. 
Published: October 2015

The average depth or traveltime in which the acoustic impedance of marine muds exceeds surrounding sands is not clearly established but is important for a host of applications, such as geohazard analysis for deepwater drilling, slope stability, and prospecting for natural gas hydrates. We have established a practical depth and time for the mud-sand crossover. We have assembled the largest bulk density and compressional velocity data set for marine muds in the first 1200 m below the seafloor (mbsf) from drilling data. The marine mud data set is combined with laboratory data for sands at pressure to determine the physical property trends and crossovers in the average marine sediment column. We have used a simple lithologic model, the average marine mud and sand trends, and a Ricker wavelet to link the physical properties to marine seismic data. We found that a seismic mud-sand crossover occurs, on average, at 875 mbsf, which is approximately [Formula: see text] two-way time below the seafloor. More practically, the impedance contrast between sand layers and marine mud layers may only be sufficiently visible to 500 mbsf or approximately [Formula: see text] two-way time due to the similar acoustic impedances of muds and sands below that depth.
Like Not Like: Writing Portraits in The Peony Pavilion
Authors: Burkus-Chasson Anne 
Published: October 2015

Abstract
In this essay, the author examines the portraits that are featured in Tang Xianzu's The Peony Pavilion. The textual portraits are mixed in nature. They contain semiotic elements that can be readily described in language and understood through iconographical interpretation. But other elements in the textual portrait cannot be fully captured by words. The latter apparently fascinated Tang Xianzu, for he explained the source of inspired writing by comparing a writer to a painter. In The Peony Pavilion, the ambiguous and unfinished pictorial marks in Du Liniang's self-portrait—its “antisemiotic elements,” a phrase borrowed from James Elkins—are prominent. This picture thus conveniently partakes in the play's comedy of errors, for at times it cannot be fully or even partially recognized. Without discounting the representational potential of pictures and other ritual objects, such as imperial portraits, Tang probes in The Peony Pavilion the mimetic and the nonrepresentational elements of writing and picture making.
Care Certificate Standards 1 and 2: your role and your personal development
Authors: Peate Ian 
Published: October 2015

This article is the first in a series that will address all 15 standards of the Care Certificate. The Care Certificate provides healthcare assistants and assistant practitioners (HCAs and APs) in any care setting with the knowledge and skills needed to offer safe, compassionate care. There are 15 standards associated with the Care Certificate. When the HCA or AP has been assessed as being competent against all of the standards within the Care Certificate, the Certificate can be awarded. In this article, we look at the first two standards of the Care Certificate, which focus on the importance of understanding your role and why your personal development is key in offering care to people that is safe and effective. Lifelong learning is seen as a key component of working in an effective manner, with the patient at the heart of all that is done.
Más allá del modelo del problem–solving
Authors: Burgos Carlos Eduardo 
Published: October 2015

En este artículo se analiza la inadecuación de la teoría del diseño actual (mainstream) para comprender la complejidad de la praxis proyectual y el modo en que sus resultados modifican o impactan en la producción cultural. Desde este contexto se cuestiona la definición del diseño como una actividad autónoma de problem-solving. Para ello se introduce el concepto de investigación proyectual como categoría clave para avanzar en la elucidación del tipo particular de práctica que implica el diseño, en un contexto ontoepistémico y metodológico ampliado, a partir del cual puedan construirse vinculaciones con otras disciplinas con base representacional. Esta cuestión es analizada a partir de categorías y estrategias consistentes con la investigación filosófica y la sistematización teórica utilizando los antecedentes que la literatura especializada proporciona. Los resultados permiten ubicar al proceso de diseño en un contexto [trans]disciplinar expandido y comprender sus sistemas de prácticas como procesos de investigación y producción tanto semiótico-cognitivos como tecnológico–productivos.
Palabras clave
epistemología; filosofía de la Ciencia; metodología; representaciones; teoría del Diseño