bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Assist for Arthritis Studies: A 3D Cell Culture of Human Fibroblast‐Like Synoviocytes by Encapsulation in a Chitosan‐Based Hydrogel
Authors: Bisconti Francesco , Vilardo Beatrice , Corallo Gaia , Scalera Francesca , Gigli Giuseppe , Chiocchetti Annalisa , Polini Alessandro , Gervaso Francesca 
Published: August 2024

AbstractOsteoarthritis (OA) and Rheumatoid arthritis (RA) are the most common arthritis in which the synovium is involved, but the cellular and molecular basis of these pathologies still need better elucidation. Fibroblast‐like synoviocytes (FLS), one of the cellular elements of the synovium, play a key role in RA, an autoimmune disease characterized by joint inflammation and systemic symptoms that afflicts 1% of worldwide population. Despite articular damage starts from synovium and then proceeds involving cartilage till bone erosion, several 3D in vitro models are reported for cartilage and bone while only a few studies focused on the synovial component. Here, a hydrogel formulation suitable for 3D culturing human fibroblast‐like synoviocytes and evaluated its suitability with non‐RA and RA patients derived‐cells is developed. Among different formulations, a chitosan (Cs)‐based hydrogel, constituted by 70% of Cs and 30% of Matrigel, showed the best results in terms of stability as well as cell growth and morphology: non‐RA and RA FLS are able to grow within the hydrogel forming a complex 3D network. Thanks to the low cost, and high market availability of chitosan, this system represents a good alternative to the use of sole Matrigel for encapsulating human synoviocytes.
KS‐133/KS‐487 Nanoparticles Exhibit Potent Antitumor Effects through Synergistic LRP1 Targeting and VIPR2 Inhibition: Therapeutic Nanoarchitectonics for Solid Tumors
Authors: Sakamoto Kotaro , Nishiyama Taisei , Miyako Eijiro 
Published: August 2024

AbstractVIPR2 is associated with psychiatric disorders, breast cancer metastasis, and cancer immunostimulation. The VIPR2 antagonist KS‐133 changes the polarity of macrophages to the M1 type, and nanoparticles (NPs) releasing KS‐133 exhibit antitumor effects against mouse colon cancer cells (CT26) in vivo. To enhance the antitumor effect of KS‐133 NPs, KS‐133 NPs are combined with the peptide KS‐487 targeting LRP1, which is expressed on CT26 cells. Subcutaneous injection of NPs containing indocyanine green (ICG) fluorescent dye and presenting KS‐487 in CT26 subcutaneous tumor‐bearing mice resulted in significant accumulation of ICG in the CT26 tumor compared to administration of NPs without KS‐487. NPs containing KS‐133 and presenting KS‐487 (KS‐133/KS‐487 NPs) exhibited dose‐dependent antitumor effects in CT26 subcutaneous tumor‐bearing mice; the antitumor effects are more potent than the effects of KS‐133 NPs without KS‐487. In addition, CD8‐positive T cells and macrophages significantly infiltrated into CT26 tumors after injection of KS‐133/KS‐487 NPs. Thus, KS‐133/KS‐487 NPs efficiently deliver KS‐133 to CT26 tumors via LRP1‐targeting and activate immune system cells such as CD8 positive T cells and macrophages via KS‐133 inhibition of VIPR2 signaling, resulting in antitumor effects. These results demonstrate the potential of KS‐133/KS‐487 NPs as a therapeutic candidate for treating solid tumors.
Printed Memristors: An Overview of Ink, Materials, Deposition Techniques, and Applications
Authors: Franco Miguel , Kiazadeh Asal , Martins Rodrigo , Lanceros‐Méndez Senentxu , Carlos Emanuel 
Published: August 2024

AbstractIndustry 4.0 is accelerating the growth of connected devices, resulting in an exponential increase in generated data. The current semiconductor technology is facing challenges in miniaturization and power consumption, demanding for more efficient computation where new materials and devices need to be implemented. One of the most promising candidates for the next technological leap is the memristor. Due to their up‐scale manufacturing, the majority of memristors employed conventional deposition techniques (physical and chemical vapor deposition), which can be highly costly. Recently, printed memristors have gained a lot of attention because of their potential for large‐scale, fast, and affordable manufacturing. They can also help to reduce material waste, which supports the transition to a more sustainable and environmentally friendly economy. This review provides a perspective on the potential of printed electronics in the fabrication of memristive devices, presenting an overview of the main printing techniques, most suitable for memristors development. Additionally, it focuses on the materials used for the switching layer by comparing its performance. Ultimately, the application of printed memristors is highlighted by showing the tremendous evolution in this field, as well as the main challenges and opportunities that printed memristors are expected to face in the following years.
Adsorption–Activation Bifunctional Center of Al/Co‐Base Catalyst for Boosting 5‐Hydroxymethylfurfural Oxidation
Authors: Dai Hongliang , Huang Yifei , Bai Hongye , Li Hongping , Zhao Huaiquan , Wang Fagen , Fan Weiqiang , Shi Weidong 
Published: August 2024

AbstractElectrocatalytic conversion of biomass‐derived 5‐hydroxymethylfurfural (HMF) to value‐added 2,5‐furandicarboxylic acid (FDCA) is of great significance in compensating for the rapid consumption of fossil resources. However, it is a challenge to further improve the performance of HMF electrocatalytic oxidation (HMFOR) by synergistic kinetics (active sites) and thermodynamics (adsorption sites). In this work, Al(OH)3/Co(OH)2 is successfully fabricated as an efficient catalyst, and its catalytic mechanism for HMF oxidation is clarified. Extended X‐ray absorption fine structure (EXAFS) analysis demonstrate that electrochemically generated Co3+ is the main catalytic site for HMF oxidation. The HMF equilibrium adsorption capacity of Al(OH)3 reach 57.0 mg g−1, which effectively increase the initial concentration of substrate and promoted the reaction rate. The combined results, based on 24 stable cycles and an FDCA yield retention rate of 98.6% after 180 days, are the highest ever achieved. Additionally, it is shown that this system can oxidize four other biomass‐derived substrates. Therefore, this work provides insight into a hydroxide catalyst that owes its efficiency to synergy between active and adsorption sites.
Winter wheat yield stability as affected by fertilizer‐N, tillage, and yield environment
Authors: Obour Augustine K. , Holman Johnathan D. , Prasad P. V. V. , Assefa Yared 
Published: August 2024

AbstractWith an increase in the frequency of hot‐dry‐windy weather and reported significant increase in winter wheat (Triticum aestivum L.) in‐season average temperatures, it is important to understand how soil management affects yield stability. This study quantified the combined effects of tillage and fertilizer‐N on winter wheat yield stability in a wheat–sorghum [Sorghum bicolor (L.) Moench]–fallow crop rotation. The research was conducted from 1975 to 2022 and the experimental design was a randomized complete block with a split‐split‐plot arrangement. Crop phases were the main plots, tillage (conventional tillage [CT], reduced tillage [RT], and no‐tillage [NT]) in the sub‐plot, and N application rates (0, 22, 45, and 67 kg N ha−1 or 0, 45, 90, and 134 kg N ha−1) in the sub‐sub‐plot. Results showed winter wheat yield under NT increased by 0.8 Mg ha−1, compared with about 1.1 Mg ha−1 for CT and RT, when environmental average increased by 1 Mg ha−1 for N rates ≤90 kg ha−1. Yields with CT and RT increased by 0.8 Mg ha−1, compared with about 1.1 Mg ha−1 rate for NT, when environmental average increased by 1 Mg ha−1 for N >90 kg ha−1. In 30%–52% of the time, CT wheat yield was greater than NT, but yield advantage with CT decreased as fertilizer‐N rate increases. Yield stability of winter wheat varied by tillage and fertilizer rate. We concluded that NT wheat required greater N rates to reach the same yield potential as CT and RT, and long‐term CT or RT wheat at 45 kg N ha−1 was most stable.
Safe transportation and targeted destruction: Albumin encapsulated aggregation‐induced emission photosensitizer nanoaggregate for tumor photodynamic therapy through mitochondria damage‐triggered pyroptosis
Authors: Cao Juanmei , Qu Yong , Zhu Shaojie , Zhan Jinshan , Xu Yiting , Jin Yifan , Wang Yuqing , Li Zhuoxia , Chai Chuxing , Wu Xiangwei , Gao Meng , Huang Changzheng , Li Min 
Published: August 2024

AbstractPhotodynamic therapy is a highly recommended alternative treatment for solid tumors, such as cutaneous or luminal tumors, in clinical practice. However, conventional photosensitizers (PSs) often induce undesirable phototoxic effects because of their normal tissue distribution and a reduction in antitumor effects resulting from aggregation‐caused quenching effects. The present study developed a novel nano‐formulated aggregation‐induced emission (AIE)‐characteristic PS, nab‐TTVPHE, which is composed of human serum albumin as a carrier and TTVPHE as a therapeutic agent, as a more effective cancer treatment with lower phototoxic effects. Notably, the reactive oxygen species generated by TTVPHE were shielded by the nanoaggregate structure, and the photodynamic activity was after nanostructure dissociation. Nab‐TTVPHE was actively internalized in tumor cells via secreted protein, acidic and rich in cysteine and released to form nanoaggregates. TTVPHE accumulated in mitochondria, where it triggered mitochondrial damage under light irradiation via its photodynamic activity and induced pyroptosis via the caspase‐3/gasdermin E (GSDME) signaling pathway to kill tumor cells. Therefore, this nano‐formulated AIE‐characteristic PS provides an innovative strategy for cancer treatment with lower phototoxic effect and the ability to boost potential antitumor immunity via GSDME‐mediated pyroptosis.
Ultralong thermally activated delayed fluorescence based on intermolecular charge transfer induced by isomer in carbazole derivative
Authors: Chen Junru , Zhang Xianhe , Xie Zongliang , Liu Bin 
Published: August 2024

AbstractUltralong thermally activated delayed fluorescence (UTADF) materials play an important role in realizing time‐dependent color‐tunable afterglow. Some typical carbazole (Cz) derivatives have been reported to exhibit UTADF properties. However, a 10‐fold difference in TADF lifetime was found between commercial Cz derivatives and the corresponding lab‐synthesized ones, which indicated that UTADF may not be derived from the single Cz derivatives as reported. To reveal the real mechanism, we synthesized three Cz derivatives and one isomer to form three host‐guest pairs for optical studies. The photophysical properties revealed that UTADF originated from the intermolecular charge transfer between host and guest, while the ultralong organic phosphorescence was from the guest. Thanks to the rich color variations in luminescence displayed by 4‐(1H‐benzo[f]indol‐1‐yl)−4′‐(9H‐carbazol‐9‐yl)‐[1,1′‐biphenyl]−3,3′‐dicarbonitrile/4,4′‐di(9H‐carbazol‐9‐yl)‐[1,1′‐biphenyl]−3,3′‐dicarbonitrile (CBP‐2CN) at different delay times, it can be applied to realize multi‐dimensional encryption in both delay time and luminescent color.
In memory of our mentor: Frans de Waal (1948–2024)
Authors: Brosnan Sarah F. , Aureli Filippo , Bonnie Kristin , Calcutt Sarah , Campbell Matthew , Carter Devyn , Clay Zanna , Danforth Marietta D. , Eppley Timothy M. , Flack Jessica , Hall Katie , Huneycutt Sarah , Judge Peter , Long Darren , Parish Amy , Plotnik Joshua M. , Pokorny Jennifer J. , Preston Stephanie D. , Proctor Darby , Romero Teresa , Seres Michael , Suchak Malini , Verbeek Peter , Weaver Ann , Webb Christine 
Published: August 2024

AbstractThe world lost a towering figure when primatologist Frans de Waal passed away on March 14, 2024. Many are aware of his multitude of contributions to the field. His ability to see what animals were actually doing changed how we viewed first primates, then other species. He shared these insights through both traditional scientific outputs, such as journal articles and scientific presentations, and less common outputs, such as 15 books and two TED talks viewed millions of times. What may be less well known is his impact as a mentor. Here, 25 of us who were Frans' graduate students, postdocs, and long‐term research assistants share his personal impact on our lives.
The Bayesian approach for real‐world implementation of plasma p‐tau217 in tertiary care memory clinics in Thailand
Authors: Thanapornsangsuth Poosanu , Booncharoen Kittithatch , Khieukhajee Jedsada , Luechaipanit Watayuth , Haethaisong Thanaporn , Chongsuksantikul Adipa , Supharatpariyakorn Thirawat , Chunharas Chaipat , Likitjaroen Yuttachai , Hemachudha Thiravat 
Published: August 2024

AbstractINTRODUCTIONPlasma phosphorylated tau (p‐tau)217 is a promising biomarker for Alzheimer's disease (AD) diagnosis, but its clinical implementation remains challenging. We propose a strategy based on Bayes’ theorem and test it in real‐life memory clinics.METHODSMemory clinic patients were evaluated by neurocognitive specialists for prespecified diagnosis and subsequently underwent blood collection for p‐tau217, cerebrospinal fluid, or amyloid positron emission tomography. Using cross‐validation, the Bayesian approach (pretest probability × individualized likelihood ratio) was compared to other models for AD diagnosis.RESULTSThe Bayesian strategy demonstrated an area under the receiver operating characteristic curve (AUC) of 0.98 (95% confidence interval [CI]: 0.96–1.0), significantly outperforming multivariable logistic regression (p‐tau217, age, apolipoprotein E; AUC 0.95, p = 0.024) and p‐tau217 alone (AUC = 0.94, p = 0.007). When applying the two‐threshold approach, the Bayesian strategy yielded an accuracy of 0.94 (95% CI: 0.88–1.0) without requiring confirmatory tests in 62.9% of the iterations.DISCUSSIONThe Bayesian strategy offers an effective and flexible approach to address the limitations of plasma p‐tau217 in clinical practice.Highlights
Incorporating pretest probability into the interpretation of plasma phosphorylated tau (p‐tau)217 improves the diagnostic performance significantly.
The strategy could obviate the need for confirmatory testing in most of the patients.
Plasma p‐tau217 proves useful as a biomarker for Alzheimer's disease in low‐ and middle‐income country such as Thailand.
SnF2‐Catalyzed Lithiophilic–Lithiophobic Gradient Interface for High‐Rate PEO‐Based All‐Solid‐State Batteries
Authors: Wu Kai , Li Ao , Tan Jin , Zhou Fu , Yan Hanbing , Wang Pengcheng , Xie Ting , Zeng Qing , Han Cuiping , Liu Qi , Li Baohua 
Published: August 2024

AbstractPolyethylene oxide (PEO)‐based all‐solid‐state lithium metal batteries (ASSLMBs) are strongly hindered by the fast dendrite growth at the Li metal/electrolyte interface, especially under large rates. The above issue stems from the suboptimal interfacial chemistry and poor Li+ transport kinetics during cycling. Herein, a SnF2‐catalyzed lithiophilic‐lithiophobic gradient solid electrolyte interphase (SCG‐SEI) of LixSny/LiF‐Li2O is in situ formed. The superior ionic LiF‐Li2O rich upper layer (17.1 nm) possesses high interfacial energy and fast Li+ diffusion channels, wherein lithiophilic LixSny alloy layer (8.4 nm) could highly reduce the nucleation overpotential with lower diffusion barrier and promote rapid electron transportation for reversible Li+ plating/stripping. Simultaneously, the insoluble SnF2‐coordinated PEO promotes the rapid Li+ ion transport in the bulk phase. As a result, an over 46.7 and 3.5 times improvements for lifespan and critical current density of symmetrical cells are achieved, respectively. Furthermore, LiFePO4‐based ASSLMBs deliver a recorded cycling performance at 5 C (over 1000 cycles with a capacity retention of 80.0 %). More importantly, impressive electrochemical performances and safety tests with LiNi0.8Mn0.1Co0.1O2 and pouch cell with LiFePO4, even under extreme conditions (i.e., 100 °C), are also demonstrated, reconfirmed the importance of lithiophilic‐lithiophobic gradient interfacial chemistry in the design of high‐rate ASSLMBs for safety applications.
Orthogonal Persulfide Generation through Precision Tools Provides Insights into Mitochondrial Sulfane Sulfur
Authors: Manna Suman , Agrawal Ragini , Yadav Tarun , Kumar T. Anand , Kumari Pooja , Dalai Aadishakti , Kanade Shaunak , Balasubramanian Nagaraj , Singh Amit , Chakrapani Harinath 
Published: August 2024

AbstractThe sulfane sulfur pool, comprised of persulfide (RS‐SH) and polysulfide (RS‐SnH) derived from hydrogen sulfide (H2S), has emerged as a major player in redox biochemistry. Mitochondria, besides energy generation, serve as significant cellular redox hubs, mediate stress response and cellular health. However, the effects of endogenous mitochondrial sulfane sulfur (MSS) remain largely uncharacterized as compared with their cytosolic counterparts, cytosolic sulfane sulfur (CSS). To investigate this, we designed a novel artificial substrate for mitochondrial 3‐mercaptopyruvate sulfurtransferase (3‐MST), a key enzyme involved in MSS biosynthesis. Using cells expressing a mitochondrion‐localized persulfide biosensor, we demonstrate this tool's ability to selectively enhance MSS. While H2S was previously known to suppress human immunodeficiency virus (HIV‐1), we found that MSS profoundly affected the HIV‐1 life cycle, mediating viral reactivation from latency. Additionally, we provide evidence for the role of the host's mitochondrial redox state, membrane potential, apoptosis, and respiration rates in managing HIV‐1 latency and reactivation. Together, dynamic fluctuations in the MSS pool have a significant and possibly conflicting effect on HIV‐1 viral latency. The precision tools developed herein allow for orthogonal generation of persulfide within both mitochondria and the cytosol and will be useful in interrogating disease biology.
Multi‐Axial Self‐Driven X‐Ray Detection by a Two‐Dimensional Biaxial Hybrid Organic‐Inorganic Perovskite Ferroelectric
Authors: Jiang Yuhang , Zhang Chengshu , Zhu Zeng‐Kui , Wu Jianbo , Yu Panpan , Zeng Ying , Ye Huang , Dai Hongliang , Li Ruiqing , Guan Qianwen , Chen Guirong , Yang Huawei , Luo Junhua 
Published: August 2024

AbstractMetal halide perovskite ferroelectrics combining spontaneous polarization and excellent semiconducting properties is an ideal platform for enabling self‐driven X‐ray detection. However, achievements to date have been only based on uniaxiality, which increases the complexity of device fabrication. Multi‐axial ferroelectric materials have multiple equivalent polarization directions, making them potentially amenable to multi‐axial self‐driven X‐ray detection, but the report on these types of materials is still a huge blank. Herein, a high‐quality (BA)2(EA)2Pb3I10 (1) biaxial ferroelectric single crystal was successfully grown, which exhibited significant spontaneous polarization along the c‐axis and b‐axis. Under X‐ray irradiation, bulk photovoltaic effect (BPVE) was exhibited along both the c‐axis and b‐axis, with open circuit voltages (Voc) of 0.23 V and 0.22 V, respectively. Then, the BPVE revealed along the inversion of polarized direction with the polarized electric fields. Intriguingly, due to the BPVE of 1, 1 achieved multi‐axial self‐driven X‐ray detection for the first time (c‐axis and b‐axis) with relatively high sensitivities and ultralow detection limits (17.2 nGyair s−1 and 19.4 nGyair s−1, respectively). This work provides a reference for the subsequent use of multi‐axial ferroelectricity for multi‐axial self‐driven optoelectronic detection.
The Formation Mechanism of Carbonized Polymer Dots: Crosslinking‐Induced Nucleation and Carbonization
Authors: Xia Chunlei , Zhong Jundong , Han Xiao , Zhu Shoujun , Li Yunfeng , Liu Hong , Yang Bai 
Published: August 2024

AbstractCarbon dots (CDs), as a kind of zero‐dimensional nanomaterials, have been widely synthesized by bottom‐up methods from various precursors. However, the formation mechanism is still unclear and controversial, which also brings difficulty to the regulation of structures and properties. Only some tentative formation processes were postulated by analyzing the products obtained at different reaction times and temperatures. Here, the effect of crosslinking on the formation of carbonized polymer dots (CPDs) is explored. Crosslinking‐induced nucleation and carbonization (CINC) is proposed as the driving force for the formation of CPDs. Under hydrothermal synthesis, the precursors are initiated to polymerize and crosslink. The crosslinking brings higher hydrophobicity to generate the hydrophilic/hydrophobic microphase separation, which promotes dehydration and carbonization resulting in the formation of CPDs. Based on the principle of CINC, the influence factors of size are also revealed. Moreover, the dissipative particle dynamics (DPD) simulation is employed to support this formation mechanism. This concept of CINC will bring light to the formation process of CPDs, as well as facilitate the regulation of CPDs’ size and photoluminescence.
Advances in Metasurface‐Based Terahertz Sensing
Authors: Zhao Jing , Zhang Lei , Liang Huawei 
Published: August 2024

AbstractTerahertz (THz) technology has attracted significant attention because of its unique applications in biological/chemical sensing, medical imaging, non‐invasive detection, and high‐speed communication. Metasurfaces provide a dynamic platform for THz sensing applications, showcasing greater flexibility in design and the ability to optimize light‐matter interactions for specific target enhancements, which includes enhancing the intramolecular and intermolecular vibration modes of the target biological/chemical molecules, setting them apart from conventional approaches. This review focuses on recent THz metasurface sensing methods, including metasurfaces based on toroidal dipole and quasi‐bound states in the continuum to improve sensing sensitivity, nanomaterial‐assisted metasurfaces for specific recognition, and metasurfaces combined with microfluidic with reduce water absorption loss. Furthermore, the applications of THz metasurface sensing is reviewed, including detecting the concentration of biomolecules, cells, tissues, and microbes, THz biomolecular fingerprint absorption spectra recognition, and identifying chiral compounds using chiral and achiral metasurfaces. Finally, the prospects for the next generation of THz sensors are examined.