bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stable operating area of photovoltaic cells feeding DC–DC converter in output voltage regulation mode
Authors: Qin Ling , Xie Shaojun , Hu Mao , Yang Chen 
Published: July 2015

From the perspective of output voltage control stability, this study investigates the stable operating area of photovoltaic (PV) cells feeding the DC–DC converter in output voltage regulation (OVR) mode. In this study, the boost interface converter is taken as an example, and its control system arrangements, small‐signal model including the dynamic equivalent circuit of PV cells and the closed‐loop transfer functions with different control loop formation are deduced at first. After that, according to the Hurwitz criterion, the essential condition for output voltage control stability is analysed and the relations between control loop formation of the interface converter in OVR mode and the stable operating area are obtained. The validity of the theoretical analysis has been verified by the experiment and simulation results of a 150 W prototype. The investigation shows that: (i) no matter what kind of control loop formation is adopted, the PV cells cannot output the maximum power when the PV interface converter operates in OVR mode; (ii) when the interface converter operates in OVR mode, PV cells can only operate stably in voltage area or current area. Moreover, the type of operating area entirely depends on the converter's output voltage control loop formation.
KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity
Authors: Dettmer Ulf , Newman Andrew J. , von Saucken Victoria E. , Bartels Tim , Selkoe Dennis 
Published: July 2015

Significance
The protein α-synuclein (αS) forms neuronal aggregates in Parkinson’s disease. Its normal folding and assembly state are unsettled. Cross-linking αS in living neurons reveals a major soluble 60-kDa form sizing as a tetramer, but the specificity of the cross-linking has been questioned. Here, we find that certain amino acid substitutions in the conserved αS “KTKEGV” repeat motifs specifically abolish the tetrameric form, indicating that cross-linking of normal αS into tetramers is not artifactual and models of monomeric αS as the major normal form should be reconsidered. An independent method, Venus-YFP complementation, confirms the cross-linking data. Importantly, tetramer abrogation causes αS insolubility, inclusions, and neurotoxicity, suggesting that the adoption of a folded tetrameric form is indispensible for normal αS homeostasis.
Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision
Authors: Boareto Marcelo , Jolly Mohit Kumar , Ben-Jacob Eshel , Onuchic José N. 
Published: July 2015

Significance
Developing effective antiangiogenesis strategies remains clinically challenging. Unlike physiological angiogenesis, pathological angiogenesis comprises of many microvessels that do not fully mature or develop functionally, because the cell fate decision about which endothelial cells become the tip and lead the following stalk cells is dysregulated. We devised a specific theoretical framework to decipher the cross-talk between two crucial players of the decision-making process of tip and stalk cell fate: VEGF and Notch-Delta-Jagged signaling. We find that high expression of Jagged, but not Delta, can destabilize the terminal differentiation into tip or stalk cells and give rise to a hybrid tip/stalk phenotype, a phenotype that can transform physiological into pathological angiogenesis. Our results offer insights into why tumor-stroma communication often implicates Jagged.
Etiology, pathogenesis, antivirals and vaccines of hand, foot, and mouth disease
Authors: Lei Xiaobo , Cui Sheng , Zhao Zhendong , Wang Jianwei 
Published: July 2015

Abstract
Hand, foot, and mouth disease (HFMD), caused by enteroviruses, is a syndrome characterized by fever with vesicular eruptions mainly on the skin of the hands, feet, and oral cavity. HFMD primarily affects infants and young children. Although infection is usually self-limited, severe neurological complications in the central nervous system can present in some cases, which can lead to death. Widespread infection of HFMD across the Asia-Pacific region over the past two decades has made HFMD a major public health challenge, ranking first among the category C notifiable communicable diseases in China every year since 2008. This review summarizes our understanding of HFMD, focusing on the etiology and pathogenesis of the disease, as well as on progress toward antivirals and vaccines. The review also discusses the implications of these studies as they relate to the control and prevention of the disease.
A Randomized Crossover Study Comparing a Novel Needle Guidance Technology for Simulated Internal Jugular Vein Cannulation
Authors: Auyong David B. , Yuan Stanley C. , Rymer Alyse N. , Green Cynthia L. , Hanson Neil A. 
Published: July 2015

AbstractAbstract
This study showed that using a simulated neck phantom and a novel needle guidance ultrasound technology decreased posterior vessel wall puncture and carotid puncture while improving needle passes and time.

Background:
Despite ultrasound guidance for central line placement, complications persist, as exact needle location is often difficult to confirm with standard two-dimension ultrasound. A novel real-time needle guidance technology has recently become available (eZono, Germany) that tracks the needle during insertion. This randomized, blinded, crossover study examined whether this needle guidance technology improved cannulation of a simulated internal jugular (IJ) vein in an ultrasound phantom.

Methods:
One hundred physicians were randomized to place a standard needle in an ultrasound neck phantom with or without the needle guidance system. Video cameras were placed externally and within the lumens of the vessels to record needle location in real time. The primary outcome measured was the rate of posterior wall puncture. Secondary outcomes included number of carotid artery punctures, number of needle passes, final needle position, time to cannulation, and comfort level with this new technology.

Results:
The incidence of posterior vessel wall puncture without and with needle guidance was 49 and 13%, respectively (P < 0.001, odds ratio [OR] = 7.33 [3.44 to 15.61]). The rate of carotid artery puncture was higher without needle navigation technology than with needle navigation 21 versus 2%, respectively (P = 0.001, OR = 12.97 [2.89 to 58.18]). Final needle tip position being located within the lumen of the IJ was 97% accurate with the navigation technology and 76% accurate with standard ultrasound (P < 0.001, OR = 10.42 [2.76 to 40.0]). Average time for successful vessel cannulation was 1.37 times longer without guidance technology.

Conclusion:
This real-time needle guidance technology (eZono) shows significant improvement in needle accuracy and cannulation time during simulated IJ vein puncture.
Breastfeeding Self‐Efficacy Scale
Authors: Petrozzi Angela , Gagliardi Luigi 
Published: July 2015

ABSTRACTPsychological factors can influence breast‐feeding. We translated into Italian and validated the Breastfeeding Self‐Efficacy Scale Short Form (BSES‐SF) and investigated its predictive ability and its relation with postpartum depression symptoms.BSES‐SF and Edinburgh Postnatal Depression Scale (EPDS) were administered 2 to 3 days after delivery to 122 mothers. Breast‐feeding was assessed at 3 months.The BSES‐SF displayed good validity (receiver operating characteristic area = 0.69) for predicting full breast‐feeding at 3 months. In multivariate analysis, the probability of full breast‐feeding increased 2.4% for 1‐point increase of BSES‐SF. The BSES‐SF and EPDS scores were inversely correlated. BSES‐SF is a useful tool to identify the risk of early breast‐feeding attrition.
In vitro aggregate formation and unusual colony morphology impairing identification of Roseomonas sp. from a septic patient
Authors: Salimnia Hossein , Fairfax Marilynn R. , Gordon James J. , Lephart Paul R. 
Published: July 2015

Introduction:
The Gram-stained morphology of organisms from positive blood culture bottles often suggests diagnoses and therapeutic options. In vitro aggregate formation by the organism in this case led to initial confusion in the diagnosis.

Case presentation:
A 57-year-old woman with a recent stroke returned to the emergency department with acute exacerbation of her neurological deficit. Although afebrile, she had an elevated white blood cell count. Urine analysis revealed 4+ blood, nitrates, leukocyte esterase and bacteria. Blood and urine cultures were collected and intravenous piperacillin/tazobactam treatment was begun. The urine culture grew >100 000 colonies Escherichia coli ml− 1; the antibiotic was changed to ceftriaxone when susceptibilities became available at 48 h. At 61 h, the aerobic blood culture bottle was flagged as positive. A Gram stain revealed spherical structures, which stained predominantly Gram-negative but were Gram-positive in some areas of the smear. Subcultures grew overnight on blood, chocolate and MacConkey agars and on brain–heart infusion (BHI) broth. Growth on MacConkey agar was sparse. A Gram stain of the snow-white, mucoid colonies revealed Gram-negative rods, spherical aggregates and thick-walled tetrads. Subsequent cultures on solid medium grew only Gram-negative rods, but inoculation of isolated colonies from these cultures into BHI broth or negative blood culture bottles caused the thick-walled spheres and tetrads to reappear.

Conclusion:
MicroScan and matrix-assisted laser desorption/ionization time of flight failed to identify the organism, but 16S rRNA gene sequencing identified it as Roseomonas genomospecies 5 (100 % match). To the best of our knowledge, there are no reports in the literature of aggregate-forming Roseomonas.
Tomato I2 immune receptor can be engineered to confer partial resistance to the oomycetePhytophthora infestansin addition to the fungusFusarium oxysporum
Authors: Giannakopoulou Artemis , Steele John F. C. , Segretin Maria Eugenia , Bozkurt Tolga O. , Zhou Ji , Robatzek Silke , Banfield Mark J. , Pais Marina , Kamoun Sophien 
Published: July 2015

AbstractPlants and animals rely on immune receptors, known as nucleotide-binding domain and leucine-rich repeat containing proteins (NB-LRR or NLR), to defend against invading pathogens and activate immune responses. How NLR receptors respond to pathogens is inadequately understood. We previously reported single-residue mutations that expand the response of the potato immune receptor R3a to AVR3aEM, a stealthy effector from the late blight oomycete pathogenPhytophthora infestans. I2, another NLR that mediates resistance to the wilt causing fungusFusarium oxysporum f. sp. lycopersici, is the tomato ortholog of R3a. We transferred previously identified R3a mutations to I2 to assess the degree to which the resulting I2 mutants have an altered response. We discovered that wild-type I2 protein responds weakly to AVR3a. One mutant in the N-terminal coiled-coil domain, I2I141N, appeared sensitized and displayed markedly increased response to AVR3a. Remarkably, I2I141Nconferred partial resistance toP. infestans.Further, I2I141Nhas an expanded response spectrum toF. oxysporum f. sp. lycopersicieffectors compared to the wild-type I2 protein. Our results suggest that synthetic immune receptors can be engineered to confer resistance to phylogenetically divergent pathogens and indicate that knowledge gathered for one NLR could be exploited to improve NLRs from other plant species.
The relationship between interpregnancy interval (IPI) and mother’s preceding pregnancies (PP)
Authors: Vernier Michel C. , Schulzer Michael , Vernier Pierre R. 
Published: July 2015

AbstractIntroductionFollowing the investigation of the mother’s preceding pregnancies on fetal development and postnatal survival of the neonate, we turned our attention to an earlier period, that is the interval separating the onset of the current pregnancy from the end of the preceding one. The objectives of this study is to investigate the variations of interpregnancy interval length associated to the mother’s preceding pregnancies.MethodsA population of 7773 neonates, alive at the time of hospital discharge, were divided into cohorts according to the current neonate’s sex and number and sex of the mother’s preceding pregnancies. Interpregnancy interval average of each cohort of same neonate’s sex and mother’s parity, but different configuration of preceding pregnancies, were measured and compared.ResultsA positive association was found between mother’s preceding pregnancies and length of interpregnancy interval when current pregnancy and preceding pregnancy were of the same sex, and a negative association when they were of opposite sex.DiscussionInterpregnancy interval length follows a pattern regarding the gravida’s preceding pregnancy similar to the other early life indicators pattern, birth weight, placenta weight, gestation length and neonatal survival. Our results confirm and complete an immunological explanation of the indicators variations associated to the gravida’s preceding pregnancy.
Automated segmentation of skin strata in reflectance confocal microscopy depth stacks
Authors: Hames Samuel C. , Ardigò Marco , Peter Soyer H. , Bradley Andrew P. , Prow Tarl W. 
Published: July 2015

AbstractReflectance confocal microscopy (RCM) is a powerful tool for in-vivo examination of a variety of skin diseases. However, current use of RCM depends on qualitative examination by a human expert to look for specific features in the different strata of the skin. Developing approaches to quantify features in RCM imagery requires an automated understanding of what anatomical strata is present in a given en-face section. This work presents an automated approach using a bag of features approach to represent en-face sections and a logistic regression classifier to classify sections into one of four classes (stratum corneum, viable epidermis, dermal-epidermal junction and papillary dermis). This approach was developed and tested using a dataset of 308 depth stacks from 54 volunteers in two age groups (20-30 and 50-70 years of age). The classification accuracy on the test set was 85.6%. The mean absolute error in determining the interface depth for each of the stratum corneum/viable epidermis, viable epidermis/dermal-epidermal junction and dermal-epidermal junction/papillary dermis interfaces were 3.1μm, 6.0μmand 5.5μmrespectively. The probabilities predicted by the classifier in the test set showed that the classifier learned an effective model of the anatomy of human skin.
Layout performance indicators and systematic planning
Authors: Flessas Milena , Rizzardi Vinicius , Tortorella Guilherme Luz , Fettermann Diego , Marodin Giuliano Almeida 
Published: July 2015

Purpose– The purpose of this paper is to plan the layout of the production area of an industrial kitchen of a theme restaurant through the application of the systematic layout planning (SLP) methodology and the establishment of layout indicators with a specific application in the restaurant business.Design/methodology/approach– The authors applied the SLP methodology in the industrial kitchen of a theme restaurant in order to plan and develop layout alternatives. Such layout alternatives were then evaluated according to a set of specific indicators consolidated based on a literature review. Finally, a multi-criteria decision-making tool was used to support the selection of the best layout alternative and suggest to the case study area.Findings– The main results could be highlighted as: first, an area, previously unexplored, of approximately 5.40 m² ended up being used as a productive area for the operations; second, 40 percent reduction in work-in-process by removing the refrigerators of groceries and the freezer from the production area; third, indirect indicators, such as customer satisfaction and the employee’s workplace environment, have increased their performance, since customers were better served and working environment became more conducive to a good employee performance.Originality/value– Most research in layout planning is typically developed in productive industrial areas, and this paper contributes to the understanding the differences of implementing SLP methodology in a food service business, such as restaurant, and proposes the utilization of specific layout indicators.
Parent voices guide smoking intervention development
Authors: Johnston Robyn , Hearn Lydia , Cross Donna , Thomas Laura T. , Bell Sharon 
Published: July 2015

Purpose– While parents’ influence on their children’s smoking behaviour is widely recognised, little is known about parents of four to eight year olds’ attitudes and beliefs around smoking cessation and how they communicate with their children about smoking. The purpose of this paper is to explore parents’ perceptions of quitting smoking and their beliefs and actions related to the use of parenting practices to discourage smoking by their children.Design/methodology/approach– Four focus groups and 17 interviews were conducted with parents (n=46) of four to eight year old children in Perth, Western Australia.Findings– Many parents indicated their children strongly influenced their quitting behaviours, however, some resented being made to feel guilty about their smoking because of their children. Parents were divided in their beliefs about the amount of influence they had on their children’s future smoking. Feelings of hypocrisy appear to influence the extent to which parents who smoked talked with their child about smoking. Parents recommended a variety of resource options to support quitting and talking with their child about smoking.Practical implications– Interventions aimed at parents who smoke and have young children should: reinforce parents’ importance as role models; highlight the importance of talking to children about smoking when they are young and provide strategies for maintaining ongoing communication; be supportive and avoid making parents feel guilty; and emphasise that quitting smoking is the best option for their child’s health (and their own), while also providing effective harm minimisation options for parents who have not yet quit.Originality/value– Parents of children of lower primary school age can be highly influential on their children’s later smoking behaviours, thus, effective interventions that address the current beliefs and practices of these parents may be particularly advantageous.
Multi-period demand allocation among supplier in a supply chain
Authors: Singh Amol 
Published: July 2015

Purpose
– This paper aims to address the problem of optimal allocation of demand of items among candidate suppliers to maximize the purchase value of items. The purchase value of the items directly relates to cost and quality of raw materials purchased from the supplier. In an increasingly competitive environment, firms are paying more attention to selecting the right suppliers for procurement of raw materials and component parts for their products. The present research work focuses on this issue of supply chain management.

Design/methodology/approach
– This present research work devises a hybrid algorithm for multi-period demand allocation among the suppliers. The customer demand is allocated by using a hybrid algorithm based on the technique for order preference by similarity to ideal solution (TOPSIS), fuzzy set theory and the mixed linear integer programming (MILP) approaches.

Findings
– The supply chain network is witnessing a changing business environment due to government policies aimed at promoting new small manufacturing enterprises (small and medium-sized enterprises) for intermediate parts and components. Hence, the managers have an option to select a new group of suppliers and allocate the optimal multi-period demand among the new group of suppliers to maximize their purchase value. In this context, the proposed hybrid model would be beneficial for the managers to operate their supply chain effectively and efficiently. The present research work will be helpful for the managers who are interested to reconfigure their supply chain under the failure of any supply chain partner or in a changing business environment. The model provides flexibility to the managers for evaluation of the different available alternatives to take a decision of optimal demand allocation among the suppliers. The proposed hybrid (fuzzy, TOPSIS and MILP) model provides more objective information for supplier evaluation and demand allocation among suppliers in a supply chain. The managers can use the proposed model to the analysis of other management decision-making problems.

Originality/value
– This present research work devises a hybrid algorithm for multi-period demand allocation among the suppliers. This hybrid algorithm prioritizes the suppliers and then allocates the multi-period demand among the suppliers. The customer demand is allocated by using a hybrid algorithm based on the technique for order preference by similarity to ideal solution (TOPSIS), fuzzy set theory and the mixed linear integer programming (MILP) approaches.
A qualitative meta-analysis of trust in supervisor-subordinate relationships
Authors: Nienaber Ann-Marie , Romeike Philipp Daniel , Searle Rosalind , Schewe Gerhard 
Published: July 2015

Purpose– Interpersonal trust is often considered as the “glue” that binds supervisors together with their subordinates, and creates a positive organisational climate. The purpose of this paper is to investigate factors affecting subordinates’ trust to their supervisor, and the consequences of such a trusting relationship.Design/methodology/approach– The authors conducted a qualitative meta-analysis of the trust literature between 1995 and 2011, to identify 73 articles and review 37 theoretical propositions, 139 significant model parameters and 58 further empirical findings.Findings– Four distinct clusters of trust antecedents are found: supervisor attributes; subordinate attributes; interpersonal processes and organisational characteristics. Similarly, the authors identify three categories of trust consequences: subordinates’ work behaviour; subordinates’ attitude towards the supervisor; and organisational level effects.Research limitations/implications– The authors find a bias towards studying supervisor attributes and interpersonal processes, yet a dearth of attention on subordinate attributes and organisational characteristics. Similarly, the conceptual attention on trust between supervisors and subordinates has been limited, with empirical work reporting predominantly significant findings. Social exchange has dominated as the theoretical perspective, and cross-section as the main research approach. In order to advance this important field more heterogeneity is needed, utilising a range of different theoretical schools and employing different methodologies.Originality/value– This seems to be the first qualitative meta-analysis explicitly directed to understanding trust between supervisors and subordinates. The authors contribute to the field of trust by revealing current gaps in the literature and highlighting potential areas of future research.