bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remarkable improvement of symptoms and signs of severe dry eye treated by ocular immersion hydrotherapy
Authors: Tao Yong , Cui Haoran , Zhang Shuang , Zhang Tao 
Published: July 2024

Key Clinical MessageTraditional treatment options are often insufficient in treating severe dry eyes caused by systemic diseases. This case demonstrates that ocular immersion hydrotherapy significantly alleviated symptoms and ocular surface inflammation in ocular graft‐versus‐host disease. Based on these findings, we propose it as a promising option for managing severe dry eye disease.AbstractThis case report investigates the efficacy of ocular immersion hydrotherapy (OIH) in treating severe dry eye secondary to ocular graft‐versus‐host disease (oGVHD). A 35‐year‐old female with a history of acute myeloid leukemia‐M2 and subsequent hematopoietic stem cell transplantation (HSCT) developed high‐intensity oGVHD unresponsive to conventional treatments, including topical corticosteroids and lubricants. We introduced OIH, utilizing sterilized swimming goggles filled with intraocular irrigating solutions, providing a moist microenvironment for the ocular surface. Symptoms were significantly relieved after treatment. Corneal filaments and epithelial defects were significantly reduced, and in vivo confocal microscopy (IVCM) demonstrated resolution of inflammation and reappearance of corneal nerves. This case indicates that OIH could be a promising therapeutic approach for severe dry eye conditions arising from oGVHD, particularly for patients refractory to traditional treatments. Further studies are warranted to elucidate the long‐term benefits and mechanisms of OIH in oGVHD management.
Dynamic Kinetic Resolution of 2‐Hydroxybiaryl Atropisomers via Lipase‐Catalyzed Enantioselective O‐Acylation
Authors: Dhiman Neha , Moustafa Gamal A. I. , Kasama Kengo , Aoyama Hiroshi , Kanomata Kyohei , Gröger Harald , Akai Shuji 
Published: July 2024

AbstractThe increasing interest in axially chiral biaryl moieties, which are prevalent in chiral ligands, organocatalysts, and bioactive molecules, has raised the need for developing novel efficient synthetic methods for these types of molecules. In addition to the currently available methods, such as kinetic resolution, desymmetrization and enantio‐ and diastereo‐selective biaryl coupling, we herein report a lipase‐catalyzed dynamic kinetic resolution (DKR) of racemic 2‐hydroxybiaryls through enantioselective O‐acylation. This method features the production of enantiomerically enriched atropisomers (89 %–98 % ee) in 91 %–99 % yields from eleven racemates. Notably, the DKR proceeds without any racemization catalyst since in situ‐racemization was achieved by easy rotation about the biaryl axis of the substrates. The enzymatic O‐acylation then furnished conformationally stable biaryl‐containing esters, in which the increased steric bulkiness of the O‐acyl moiety suppresses the rotation, i. e., racemization, under the reaction conditions of 35–50 °C. This experimental study was accompanied by a computational determination of the rotational barrier of substrates and products. The choice of suitable substrates with a significant difference in their rotational barrier compared to that of their products turned out to be the key to an efficient implementation of this method.
Influence of Catalyst Structural Remodelling on The Performance of NH3‐SCR Reactions: A Mini Review
Authors: Liu Jun , Lv Dengke , Wang Ying , Zhao Yuqiong , Li Guoqiang , Zhang Guojie 
Published: July 2024

AbstractWith the continuous expansion of industrial activities worldwide, industrial emissions of nitrogen oxides (NOx) pose a serious threat to both ecosystems and human health. Ammonia selective catalytic reduction of NO (NH3‐SCR) technology has emerged as the most effective means to reduce NOx emissions, and the development of catalysts is crucial for the successful implementation of this technology. In gas‐solid multiphase catalytic systems, the performance limitations of conventional catalysts can be effectively overcome by meticulously designing the nanostructures of the catalysts to achieve improved catalytic efficiency. In this review, the unique structural features of core‐shell structures, layered double hydroxide (LDHs), hollow nano spheres and nanotubes, along with their preparation processes, are systematically examined, beginning with the effects of structural changes on catalytic performance. Based on this review, the impact of structural modifications on the catalytic efficiency of the catalysts for the NH3‐SCR reaction and their anti‐poisoning performance were investigated. Ultimately, the influence of catalyst structural changes on the future design of catalysts is anticipated. This provides a robust scientific foundation for the conception of higher performance catalysts, paving the way for technological innovation and advancements in NOx emission reduction practices.
High‐Temperature Heat Pumps for Industrial Use
Authors: Bever Paul‐Michael , Bless Frédéric , Arpagaus Cordin , Bertsch Stefan S. 
Published: July 2024

AbstractCompared to heat pumps established in the building sector, high‐temperature heat pumps (HTHPs) suitable for industrial use still face challenges, not only from a mechanical engineering point of view but also regarding integration into existing processes. They need to supply larger amounts of heat at higher temperatures. The mere replacement of a gas boiler by an HTHP will rarely deliver an energy‐efficient solution. Instead, these units must often be tailored to the application and vice versa, making specifications a complex task. This paper intends to link thermodynamic and economic basics of HTHPs to the process engineering of the actual production process. It also ventures an outlook on the economic and regulatory boundary conditions in the EU as corner stones for a sustainable investment decision.
An SIR‐based Bayesian framework for COVID‐19 infection estimation
Authors: Wu Haoyu , Stephens David A. , Moodie Erica E. M. 
Published: July 2024

AbstractEstimating the COVID‐19 infection fatality rate, inferring the latent incidence and predicting the future epidemic evolution are critical to public health surveillance, but often challenging due to limited data availability or quality. Recently, a Bayesian framework combining time series deconvolution of deaths with a parametric Susceptible–Infectious–Recovered (SIR) model was proposed by Irons and Raftery, 2021. We assess the parameter identifiability of the model using the profile likelihood approach and simulations, when only the time series of deaths and seroprevalence survey data are available. The robustness of the model to the more complex but also more realistic Susceptible–Exposed–Infectious–Recovered (SEIR)‐based epidemics is evaluated through simulations; the influence of potential biases in the serosurveys on the inference is also investigated. We use a stationary first‐order autoregressive prior to account for the variability of transmission rate over time. The results suggest that the model is relatively robust to SEIR‐based epidemics, especially when the reproductive number is low, given sufficient information from serosurveys or priors. However, the lack of parameter identifiability under limited data availability cannot be neglected. We apply the model to infer the COVID‐19 infections in Ontario and Quebec, Canada during the Omicron era.
A Mechanistic Insight into the Acidic‐stable MnSb2O6 for Electrocatalytic Water Oxidation
Authors: Yin Li , Ding Yunxuan , Li Yingzheng , Liu Chang , Zhao Ziqi , Ning Hongxia , Zhang Peili , Li Fei , Sun Licheng , Li Fusheng 
Published: July 2024

AbstractThe abundant, active, and acidic‐stable catalysts for the oxygen evolution reaction (OER) are rare to proton exchange membrane‐based water electrolysis. Mn‐based materials show promise as electrocatalysts for OER in acid electrolytes. However, the relationship between the stability, activity and structure of Mn‐based catalysts in acidic environments remains unclear. In this study, phase‐pure MnSb2O6 was successfully prepared and investigated as a catalyst for OER in a sulfuric acid solution (pH of 2.0). A comprehensive mechanistic comparison between MnSb2O6 and Mn3O4 revealed that the rate‐determining step for OER on MnSb2O6 is the direct formation of MnIV=O from MnII−H2O by the 2H+/2e− process. This process avoids the rearrangement of adjacent MnIII intermediates, leading to outstanding stability and activity.
Clinical and translational research on cancer of the stomach and gastroesophageal junction: A pathologist's view
Authors: Röcken Christoph 
Published: July 2024

AbstractAdenocarcinomas of the stomach and gastroesophageal junction remain one of the most common malignant tumours in humans worldwide, often with a poor prognosis. Particularly in countries without upper gastrointestinal tract screening endoscopy, tumours that have been asymptomatic for a long time are only diagnosed at an advanced stage. This limits the therapeutic options. Often only palliative therapy concepts are available. Great progress has been made in the last two decades. The genetic basis of adenocarcinomas of the stomach and gastroesophageal junction has been deciphered and new targeted drugs have been developed. Cell and tissue‐based predictive diagnostics are becoming increasingly important in therapy planning. Here, surgical pathology forms an important link between basic research, clinical trials, and translation into clinical application. This review article summarizes the experiences made in translational tumour research, which point to the problems of spatial and temporal intratumoral heterogeneity of adenocarcinomas of the stomach and gastroesophageal, the development and continuous re‐assessment of therapeutically relevant cut‐off values, resistance mechanisms, tumour microenvironment, sexual dimorphism and the pitfalls molecular tumour boards may face.
B‐cell performance in chemotherapy: Unravelling the mystery of B‐cell therapeutic potential
Authors: Li Zizhuo , Lin Anqi , Gao Zhifei , Jiang Aimin , Xiong Minying , Song Jiapeng , Liu Zaoqu , Cheng Quan , Zhang Jian , Luo Peng 
Published: July 2024

AbstractBackground and main bodyThe anti‐tumour and tumour‐promoting roles of B cells in the tumour microenvironment (TME) have gained considerable attention in recent years. As essential orchestrators of humoral immunity, B cells potentially play a crucial role in anti‐tumour therapies. Chemotherapy, a mainstay in cancer treatment, influences the proliferation and function of diverse B‐cell subsets and their crosstalk with the TME. Modulating B‐cell function by targeting B cells or their associated cells may enhance chemotherapy efficacy, presenting a promising avenue for future targeted therapy investigations.ConclusionThis review explores the intricate interplay between chemotherapy and B cells, underscoring the pivotal role of B cells in chemotherapy treatment. We summarise promising B‐cell‐related therapeutic targets, illustrating the immense potential of B cells in anti‐tumour therapy. Our work lays a theoretical foundation for harnessing B cells in chemotherapy and combination strategies for cancer treatment.Key points
Chemotherapy can inhibit B‐cell proliferation and alter subset distributions and functions, including factor secretion, receptor signalling, and costimulation.
Chemotherapy can modulate complex B‐cell–T‐cell interactions with variable effects on anti‐tumour immunity.
Targeting B‐cell surface markers or signalling improves chemotherapy responses, blocks immune evasion and inhibits tumour growth.
Critical knowledge gaps remain regarding B‐cell interactions in TME, B‐cell chemoresistance mechanisms, TLS biology, heterogeneity, spatial distributions, chemotherapy drug selection and B‐cell targets that future studies should address.
Outcomes of a Virtual Day Treatment Program for Adults With Eating Disorders—Comparison With In‐Person Day Treatment
Authors: Thaler Lea , Booij Linda , St‐Hilaire Annie , Paquin‐Hodge Chloé , Mesli Nesrine , Burko Hope , Lee Viveca , Oliverio Stephanie , Israël Mimi , Steiger Howard 
Published: July 2024

ABSTRACTObjectivePrevious studies have indicated that virtual treatments for eating disorders (EDs) are roughly as effective as are in‐person treatments; the present nonrandomized study aimed to expand on the current body of evidence by comparing outcomes from a virtual day treatment program with those of an in‐person program in an adult ED sample.MethodParticipants were 109 patients who completed at least 60% of day treatment sessions (n = 55 in‐person and n = 54 virtual). Outcome measures included ED and comorbid symptoms, and motivation.ResultsLinear mixed models showed that global EDE‐Q scores decreased during treatment (AIC = 376.396, F = 10.94, p = 0.002), irrespective of treatment modality (p = 0.186). BMI significantly increased over time (AIC = 389.029, F = 27.97, p < 0.001), with no effect of treatment modality (p = 0.779).DiscussionOur findings suggest that the virtual delivery of day treatments produces comparable outcomes to those obtained using in‐person formats, and that virtual formats may represent a pragmatic treatment option, especially in situations in which access to in‐person care is limited.
Controlled Study of Pre‐ and Postoperative Headache in Patients with Sellar Masses (HEADs‐uP Study)
Authors: Slagboom Tessa N. A. , Boertien Tessel M. , Bisschop Peter H. , Fliers Eric , Baaijen Johannes C. , Hoogmoed Jantien , Drent Madeleine L. 
Published: July 2024

ABSTRACTIntroductionSellar masses are common intracranial neoplasms. Their clinical manifestations vary widely and include headache. We aimed to determine whether the prevalence and characteristics of headache in patients with sellar tumours differ from the general population and to investigate the effect of tumour resection on this complaint.MethodsWe performed a prospective, controlled study in a single tertiary centre and included 57 patients that underwent transsphenoidal resection for a sellar mass (53% females, mean age 53.5 ± 16.4) and 29 of their partners (controls; 45% females, mean age 54.8 ± 14.9). Outcome measures were prevalence, characteristics and impact of headache 1 month preoperatively and at neurosurgical follow‐up 3 months postoperatively.ResultsPreoperatively, the prevalence of regular headache (≥1 time per month) was higher in patients than in controls (54% vs. 17%, p < 0.001), and patients scored higher on headache impact questionnaires (all p ≤ 0.01). At postoperative follow‐up, headache prevalence decreased in both groups, but the decrease in regular headache frequency and impact was larger in patients than in controls, and no between‐group differences remained.ConclusionsMore than half of patients with sellar tumours suffer from at least once‐monthly headaches, and both regular headache occurrence and impact are higher compared with controls. The more pronounced decrease in headache complaints in patients versus controls at postoperative follow‐up suggests an additional effect of tumour resection next to the factor time.
Stable and Reusable Pd/Cu Bimetallic Nanoparticle Catalysts for the Synthesis of Hydroxy Isoindolones by Domino C−H Activation and Annulation
Authors: Narasimha Rao Gollapalli , Behera Mousumi , Kathirvel Krishnamoorthy , Sekar Govindasamy 
Published: July 2024

AbstractA domino C−H activation and annulation process catalyzed by stable and reusable bimetallic nanoparticles (Pd/Cu‐binapthyl nanoparticles) was developed for the synthesis of 3‐hydroxyisoindolin‐1‐ones/thiones. The scope of the reaction was examined utilizing a variety of N‐alkoxy benzamide/benzothioamide derivatives and benzaldehydes, which yielded moderate to good yields of 3‐hydroxyisoindolin‐1‐ones/thiones, one of which was used to synthesize a BRD4 inhibitor. A gram‐scale synthesis is also reported. The Pd/Cu‐binapthyl nanocatalyst has been recovered and reused up to four times without any major change in particle size and reactivity.
Investigation into the overcurrent failure and combustion characteristics of copper‐clad aluminum conductors
Authors: Wang Weifeng , He Di , Zhao Xuanchong , Ji Xiaohan , Zhang Fangzhi , Wang Lin , Yang Ze 
Published: July 2024

AbstractElectrical fires perennially rank first in fire occurrence types, with conductor overcurrent being one of the main inducements. This topic draws significant attention from scientific researchers and fire investigators. To understand the overcurrent fault and combustion characteristics of copper‐clad aluminum conductors, this paper examines 2.5 mm2 copper‐clad aluminum conductors that meet national standards, investigating morphological changes, temperature variations in the core and insulation layer, and flame propagation patterns under overcurrent conditions. Experiments using an electrical fault simulation device were conducted to study overcurrent failures of copper‐clad aluminum conductors under 52.5–105 A conditions. The results indicate that when the current exceeds 67.5 A, the conductor undergoes a series of changes during energization, including smoking, expanding, carbonizing, burning, and breaking; at 52.5 A, the insulation layer reaches thermal equilibrium at 150 s without combustion; for currents between 60–67.5 A, wire core temperature variations can be divided into three stages; at 75 A, the insulation layer reaches thermal equilibrium 10s before breaking; currents above 82.5 A see a sharp increase in temperature in both the core and insulation layer before the conductor breaks; above 97.5 A, the conductor first breaks and then burns. The research results have significant theoretical value in improving the scientific rigor of fire accident investigations and forensic evidence examinations.
Newborn's neural representation of instrumental and vocal music as revealed by fMRI: A dynamic effective brain connectivity study
Authors: Loukas Serafeim , Filippa Manuela , de Almeida Joana Sa , Boehringer Andrew S. , Tolsa Cristina Borradori , Barcos‐Munoz Francisca , Grandjean Didier M. , van de Ville Dimitri , Hüppi Petra S. 
Published: July 2024

AbstractMusic is ubiquitous, both in its instrumental and vocal forms. While speech perception at birth has been at the core of an extensive corpus of research, the origins of the ability to discriminate instrumental or vocal melodies is still not well investigated. In previous studies comparing vocal and musical perception, the vocal stimuli were mainly related to speaking, including language, and not to the non‐language singing voice. In the present study, to better compare a melodic instrumental line with the voice, we used singing as a comparison stimulus, to reduce the dissimilarities between the two stimuli as much as possible, separating language perception from vocal musical perception. In the present study, 45 newborns were scanned, 10 full‐term born infants and 35 preterm infants at term‐equivalent age (mean gestational age at test = 40.17 weeks, SD = 0.44) using functional magnetic resonance imaging while listening to five melodies played by a musical instrument (flute) or sung by a female voice. To examine the dynamic task‐based effective connectivity, we employed a psychophysiological interaction of co‐activation patterns (PPI‐CAPs) analysis, using the auditory cortices as seed region, to investigate moment‐to‐moment changes in task‐driven modulation of cortical activity during an fMRI task. Our findings reveal condition‐specific, dynamically occurring patterns of co‐activation (PPI‐CAPs). During the vocal condition, the auditory cortex co‐activates with the sensorimotor and salience networks, while during the instrumental condition, it co‐activates with the visual cortex and the superior frontal cortex. Our results show that the vocal stimulus elicits sensorimotor aspects of the auditory perception and is processed as a more salient stimulus while the instrumental condition activated higher‐order cognitive and visuo‐spatial networks. Common neural signatures for both auditory stimuli were found in the precuneus and posterior cingulate gyrus. Finally, this study adds knowledge on the dynamic brain connectivity underlying the newborns capability of early and specialized auditory processing, highlighting the relevance of dynamic approaches to study brain function in newborn populations.
The combined anterior cruciate and medial collateral ligament replacement by various materials: A comparative animal study
Authors: Claes L. , Dürselen L. , Kiefer H. , Mohr W. 
Published: July 2024

On 30 sheep, a combined replacement of the anterior cruciate and medial collateral ligament of the right knee was performed with four different materials. Dacron prostheses and glutaraldehyde‐preserved bovine tendon prostheses as well as braided ligament prostheses made of carbon fibers and braided resorbable polydioxanone fibers surrounded by lyophilized dura in their intra‐articular part were used. Ten un‐operated sheep served as a control group. After 1 year the animals were sacrificed and the knee joints were explanted and biomechanically as well as histomorphologically investigated. The gross inspection of the joints showed no ruptured medial collateral ligament replacement but did show partially and totally ruptured anterior cruciate ligament replacements. The Dacron prosthesis was broken in 50% of the cases, whereas for the other materials one ruptured ligament replacement each (12.5%) could be observed. The anterior drawer test and the determination of the tensile stiffness of the remaining ligament replacements revealed that none of the operated knees achieved the properties of the normal control knees. However, the carbon fiber implants had the best result of all prostheses tested.For all materials except the resorbable polydioxanone, abrasion particles could be found in the anterior cruciate ligament and in the synovial membrane. The tissue reaction to these particles was a mild synovitis for carbon fragments, a strong synovitis for Dacron particles, and a chronic inflammatory response to bovine tendon fragments with macrophage granulomas and fibrosis.
On Gloeotrichia Ag. from paddy fields of Kaira District, Gujarat, India
Authors: Mahajan A. D. , Patel R. J. 
Published: July 2024

SummaryDuring the study of algal flora from the rice fields of Kaira district, Gujarat, the authors collected 12 forms of genus Gloeotrichia Ag. from Limbasi and Navagam, well‐known places for paddy cultivation in Gujarat. Of these except G. raciborskii var. salsettense Dixit, all are reported for the first time from Gujarat.
Vegetation of inland desert wadis in Egypt VI. Wadi Qassab
Authors: El‐Shakawi H. M. , Fayed A. A. , Salama F. M. 
Published: July 2024

SummarySporadie torrential rains drain the Red Sea mountain ranges into wadi systems that pour huge amounts of water and sediments into either the outskirts of the Nile valley or the Red Sea coast. Wadi Qassab is one of the former group that received considerable amounts of surface runoff waters in December 1980, thus calling for this investigation. Fourty eight species comprising the vegetation of the wadi are seggregated in two community types not previously recorded in this desert: 1. Zygophyllum simplex‐Frankenia pulverulenta community and 2. Salsola baryosma‐Ochradenus baccatus community. Fourteen species are common to both communities and are considered as members of the alliance «Zygo coceineum“ previously recognized in other wadis of this desert.
Infrageneric chemosystematics of some cultivated species of Ixora L.
Authors: Mai K. Kiran , Radhakrishnaiah M. , Narayana L. L. 
Published: July 2024

SummaryThe chemataxonomy of six cultivated species of Ixora is studied with reference to the distribution of different classes of chemical constituents and phenolic compounds. The quantified chemical data, presented in the form of synthetic numerical indices and dendrogram are suggestive of close chemical ties among them and support their placement in one section.