bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Calcium Propionate Dip and Spray Applications on Botrytis Blight of Ornamental Plants
Authors: Borda Ana Maria , Gelain Jhulia , Minzheng Cai , Luo Chao-Xi , Schnabel Guido , Faust James E. 
Published: July 2024

The use of conventional fungicides to control Botrytis blight of ornamentals caused by Botrytis cinerea has its limitations due to increasing resistance to site-specific fungicides. Calcium propionate (CaP) has suppressive action against this disease, and resistance in B. cinerea to CaP has not been reported. This study evaluated the efficacy of postharvest dip applications of 0.1% CaP (pH 6.0) to control Botrytis blight in four cut rose ( Rosa × hybrida) cultivars and analyzed gene expression of CaP-treated rose petals. CaP reduced Botrytis blight symptoms in rose ‘Alive’ but not in ‘Freedom’, ‘Momentum’, and ‘Orange Crush’, and no change in gene expression in ‘Orange Crush’ was detected following CaP treatment. Aerial spray applications at 0.1, 0.2, 0.3, 0.4, and 0.5% CaP made twice a week for 5 weeks caused minimal phytotoxicity damage to calendula ( Calendula officinalis), carnation ( Dianthus sp.), dahlia ( Dahlia sp.), pansy ( Viola × wittrockiana), and snapdragon ( Antirrhinum majus) leaves; however, CaP spray applications generated residues at all CaP concentrations in all species except for dahlia, where no residue was observed. The results suggest that CaP will suppress Botrytis blight in some but not all rose cultivars and establish a reference for phytotoxicity symptoms and visible CaP residues on ornamental plants. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Virtual Reality for Subacute Pain After Orthopedic Traumatic Musculoskeletal Injuries
Authors: Mace Ryan A. , Brewer Julie R. , Cohen Joshua E. , Ly Thuan V. , Weaver Michael J. , Borsook David 
Published: July 2024

Objectives:
Acute orthopedic traumatic musculoskeletal injuries are prevalent, costly, and often lead to persistent pain and functional limitations. Psychological risk factors (eg, pain catastrophizing and anxiety) exacerbate these outcomes but are often overlooked in acute orthopedic care. Addressing gaps in current treatment approaches, this mixed-methods pilot study explored the use of a therapeutic virtual reality (VR; RelieVRx), integrating principles of mindfulness and cognitive-behavioral therapy, for pain self-management at home following orthopedic injury.

Methods:
We enrolled 10 adults with acute orthopedic injuries and elevated pain catastrophizing or pain anxiety from Level 1 Trauma Clinics within the Mass General Brigham health care system. Participants completed daily RelieVRx sessions at home for 8 weeks, which included pain education, relaxation, mindfulness, games, and dynamic breathing biofeedback. Primary outcomes were a priori feasibility, appropriateness, acceptability, satisfaction, and safety. Secondary outcomes were pre-post measures of pain, physical function, sleep, depression, and hypothesized mechanisms (pain self-efficacy, mindfulness, and coping).

Results:
The VR and study procedures met or exceeded all benchmarks. We observed preliminary improvements in pain, physical functioning, sleep, depression, and mechanisms. Qualitative exit interviews confirmed high satisfaction with RelieVRx and yielded recommendations for promoting VR-based trials with orthopedic patients.

Discussion:
The results support a larger randomized clinical trial of RelieVRx versus a sham placebo control to replicate the findings and explore mechanisms. There is potential for self-guided VR to promote evidence-based pain management strategies and address the critical mental health care gap for patients following acute orthopedic injuries.
Can We Screen for Limb Length Discrepancy on Spinal Radiographs of Patients With Adolescent Idiopathic Scoliosis?
Authors: Mishra Neeraj , Lee Nicole Kim Luan , Loo Liang Hui , Lim Kevin Boon Leong 
Published: July 2024

Background:
The aim of this study was to determine whether height differences in the levels of the iliac crests and femoral heads on erect spinal radiographs can be used as indirect measurements for the screening and surveillance of limb length discrepancy (LLD) in patients with scoliosis.

Methods:
Whole body posteroanterior (PA) and lateral erect radiographs of patients with adolescent idiopathic scoliosis (AIS) were retrospectively reviewed. Patients with congenital, syndromic, and neuromuscular scoliosis were excluded. A direct measurement of each limb was taken from the highest point of the femoral head to the middle of the tibial plafond; any difference between the sides was recorded as the LLD. In addition, the PACS Software tool was used to measure femoral head height difference (FHHD) and iliac crest height difference (ICHD). Pearson’s correlation, linear regression, and Bland–Altman plots were used to determine the relationships between LLD and FHHD, and LLD and ICHD.

Results:
Radiographs of 141 patients (92 women, 49 men) with an average age of 12.0±2.65 years were analyzed. A strong correlation (r=0.730, P<0.001) was found between LLD and FHHD; the correlation between LLD and ICHD was weaker (r=0.585, P<0.001). The Bland–Altman analysis showed good agreements of LLD with FHHD and ICHD. Linear regression analysis predicted an LLD of ≤10 mm based on an FHHD of ≤11.5 mm or an ICHD of ≤15.3 mm.

Conclusions:
FHHD and ICHD on spinal PA radiographs can be used for the screening and monitoring of LLD in patients with AIS with FHHD being the preferred indirect measurement. These measurements are readily learned and quick to perform. The FHHD and ICHD can be measured on any erect scoliosis PA radiograph. Therefore, these proxy measurements can be used to screen and monitor for LLD in patients with AIS.

Level of Evidence:
Level III.
Can the 6-minute Walking Test Assess Ambulatory Function Impairment in Patients With Cervical Spondylotic Myelopathy?
Authors: Fu Wenyang , Xu Rongkun , Wang Xia , Li Hao , Chen Xing , Wang Lianlei , Yuan Suomao , Tian Yonghao , Liu Xinyu 
Published: July 2024

Study design.
Prospective cohort study.

Objective.
Investigating the ability of a 6-minute walking test (6MWT) to assess functional status in patients with cervical spondylotic myelopathy (CSM).

Summary of Background Data.
The 6MWT provides an objective assessment of a patient’s ability to walk. There is the potential for its application to the assessment of functional status in patients with CSM.

Materials and Methods.
One hundred thirty-five patients from our institution were prospectively enrolled from July 2022 to August 2023. A control group of age-matched and sex-matched healthy individuals was established. The 6MWT was conducted in strict accordance with established guidelines. The Nurick score, the Prolo score, the Cooper-myelopathy-scale score (CMS), the Japanese Orthopedic Association score (JOA) and the European-myelopathy-scale score (EMS) were assessed preoperatively. Visual Analog Scale (VAS) for pain or numbness and Oswestry Neck Disability Index (NDI) were also collected. Radiographic parameters were measured and recorded. Continuous variables between patients and controls were compared by applying the t test. The χ2 test was used to compare gender ratios between groups. Pearson correlation analysis was used to analyze the association between continuous variables and ordinal variables. Subgroups of CSM patients were analyzed according to global spinal alignment types based on whether the SVA was ≥50 mm. Clinical scores and imaging parameters were compared by t test.

Results.
The preoperative 6-minute walking distance (6MWD) of CSM patients was 309.34 ± 116.71 m, which was significantly lower than that of the controls (464.30 ± 52.59 m, P<0.01). The 6MWD was significantly correlated with scores on all clinical scales except the VAS. CMS Lower extremity score had the strongest correlation with preoperative 6MWD in CSM patients (r=−0.794, P<0.01). Of the sagittal alignment parameters, only C7 sagittal vertical axis (SVA) and T1 slope were significantly correlated with 6MWD(r=−0.510, −0.360, respectively). CSM patients with SVA >50 mm had significantly lower 6MWD than CSM patients with SVA ≤50 mm (168.00 ± 137.26 vs. 346.24 ± 84.27 m, P<.01).

Conclusions.
The 6MWD of CSM patients was significantly lower than that of the healthy population and correlated well with commonly used clinical scales. The 6MWD can potentially assist in the assessment of functional status in patients with CSM.
Randomized Controlled Trial to Assess Negative Pressure Wound Therapy versus Standard-of-care Dressings in Breast Surgery: A Pilot Study
Authors: Chow Oliver , Graham Susannah , Ricciardello Daniel , Davies Matthew , Lajevardi Sepehr , Hussain Gazi , Deva Anand K. 
Published: July 2024

Background:
Standard breast reduction dressings such as Prineo are used to cover surgical wounds, in combination with a binder or support bra. The Prevena Restor BellaForm is a negative pressure wound therapy dressing that covers the entirety of the breast mound and is purported to provide further support and reduce swelling. The aim of this study was to compare the Restor to standard-of-care dressings.

Methods:
The study was a randomized control trial of women undergoing bilateral breast reduction with one breast being dressed with the Prevena Restor BellaForm dressing and the other having standard of care (Prineo). Outcomes measured were drain outputs, postoperative length of stay, quality of scarring, patient preference for dressings, and adverse events. Follow-up was at 1, 2–6, and 26 weeks.

Results:
The results show a reduction in postoperative days 1 and 2 average drain output on the Restor side compared with standard dressings. Patient-reported outcome measures showed less bruising. There was no difference in postoperative length of stay and no difference in appearance of scars at the 26-week follow-up period. One patient required removal of the dressing due to irritation and one patient required assistance with resealing of the vacuum.

Conclusions:
We have shown benefits to drain output and comfort using close incisional negative pressure therapy in breast reduction mammaplasty. We plan to continue to investigate close incisional negative pressure therapy in larger comparative trials for other breast procedures including implant-based reconstruction, where a reduction in drain output could be of great benefit to both healing and reduction of infection risk.
Comparing the hemodynamic changes, bleeding, and surgeon’s satisfaction during rhinoplasty surgery by use of two drugs, labetalol and dexmedetomidine added to anesthetic technique: a randomized clinical trial
Authors: Radman Masoud , Mousavi Nila , Jadidi Fatemeh , Ayoobi Fatemeh 
Published: July 2024

Background:
Rhinoplasty is a common surgery in the world. Bleeding is a common concern during rhinoplasty. Hemodynamic stability and quality of view of the surgical field help to achieve the best results. The aim was to compare the effect of two drugs, dexmedetomidine and labetalol, on the amount of bleeding and satisfaction with rhinoplasty surgery.

Methods:
A cross-sectional descriptive study includes candidates for rhinoplasty surgery, referring to Moradi Hospital in Rafsanjan. Twenty patients were assigned to each group (dexmedetomidine and labetalol) based on the entry and exit criteria. Systolic and diastolic blood pressures and mean arterial pressure were measured before, 20 minutes after complete anesthesia, and the start of rhinoplasty surgery. All patients were operated by the same surgeon using the same technique. The surgeon’s level of satisfaction indicated with the field of vision is given as follows: good, moderate, and poor.

Results:
The study was performed on 40 subjects in two groups (n = 20), of which 14 (35 %) were male and 26 (65 %) were female. The results presented statistically significant differences in mean osteotomy systolic blood pressure (P = 0.018), osteotomy diastolic blood pressure (P = 0.015), mean osteotomy arterial pressure (P = 0.002), after 20 minutes heart rate (P < 0.001), and osteotomy heart rate (P = 0.001) between two groups. Furthermore, significant differences were observed regarding systolic blood pressure (P = 0.015), mean arterial pressure (P = 0.03), and heart rate (P < 0.001) after controlling for the effect of the group.

Conclusions:
The labetalol is the preferred option for controlling hypotension that provides better surgical field visibility compared to dexmedetomidine in rhinoplasty surgery.
Psychological General Well-being, Cognitive Failure, and Inflammation Biomarkers Among Workers 4 Months After a Mild/Asymptomatic SARS-CoV-2 Infection
Authors: Stufano Angela , Lucchese Guglielmo , Schino Valentina , Plantone Domenico , de Maria Luigi , Vimercati Luigi , Floel Agnes , Iavicoli Ivo , Lovreglio Piero 
Published: July 2024

Objective
To investigate the relationship between cognitive complaints, systemic inflammatory biomarkers, and psychological general well-being (PGWB) after mild/asymptomatic SARS-CoV-2 infection, according to the presence of long COVID and work tasks.

Methods
University employees and metal workers were recruited in a cross-sectional study 4 months after SARS-CoV-2 infection to assess cognitive impairment, individual PGWB index, inflammatory biomarkers, namely platelet-lymphocyte, neutrophil-lymphocyte, and lymphocyte-monocyte ratios, and the presence of long COVID symptoms.

Results
A significant increase in the levels of inflammatory biomarkers was observed in subjects with long COVID. Furthermore, the PGWB index was influenced by long COVID symptoms and subjective cognitive and depressive symptoms, but not by work activity.

Conclusions
In occupational settings, it is crucial to detect the presence of long COVID symptoms and systemic inflammation early, as they may be associated with lower PGWB.
Cardiorespiratory Fitness Associates Negatively With Arterial Stiffness in a Cohort of Industrial Workers Followed Up for 4 Years
Authors: Skogstad Marit , Skare Øivind , Mamen Asgeir , Zardin Erika , Sirnes Per Anton 
Published: July 2024

Objective
Previously, we have found increased carotid-to-femoral pulse wave velocity (cfPWV) among shift workers compared to day workers in industry, and a decline in maximal oxygen uptake (V̇O2max) in all 86 workers.

Methods
Utilizing all available measurements in 2018, 2021, and 2022, this study investigated associations between V̇O2max and measures of arterial stiffness. Using a mixed model approach, we analyzed the cross-sectional association between all V̇O2max (outcome) and measures of arterial stiffness (covariates).

Results
We observed a significant association between V̇O2max and cfPWV of −1.59 (95% confidence interval [CI], −3.03 to −0.16), and between augmentation pressure (AP) and augmentation index (Aix) of −0.32 (95% CI, −0.58 to −0.06) and −0.12 (95% CI, –0.23 to −0.005), respectively.

Conclusions
We found a significant negative association between cardiorespiratory fitness and measures of arterial stiffness. The former and present results pose challenges for shift workers' future macrovascular and microvascular health.
Comparative Analysis of Upper Limb Impairment Rating Processes in the American Medical Association Guides Sixth Edition 2024 Versus 2008
Authors: Melhorn J. Mark , Gelinas Barry , Martin Douglas W. , Hegmann Kurt T. , Thiese Matthew S. 
Published: July 2024

Objectives
The aims of the study are to evaluate how upper limb impairment ratings are affected by updates to the AMA Guides to the Evaluation of Permanent Impairment (AMA Guides) Sixth Edition 2024 compared with the AMA Guides Sixth Edition 2008 and to investigate potential correlations with judicial, legislative, and economic factors.

Methods
Two expert evaluators reviewed 31 upper limb clinical vignettes from the 2008 and 2024 versions. The impairment ratings for each version were compared.

Results
After following the impairment ratings steps in each version, the results for 2024 showed no significant differences when compared with the impairment ratings generated using 2008 methods (Cohen’s kappa = 1.00).

Conclusions
The updated AMA Guides Sixth Edition 2024 with improved, transparent processes and enhanced diagnosis-based impairment tables provides efficiency while retaining the accuracy, validity, and reliability of past versions of the AMA Guides.
Duration of surgical antibiotic prophylaxis and surgical site infection in orthopaedic surgery: a prospective cohort study
Authors: Yang Zhenbang , Wang Yuchuan , Wang Zhongzheng , Li Junyong , Du Pei , Meng Hongyu , Zhao Kuo , Zhang Junzhe , Li Ming , Jin Zhucheng , Peng Ziheng , Ye Dandan , Ding Kai , Lv Hongzhi , Wang Juan , Xing Xin , Song Zhaohui , Chen Wei , Zhu Yanbin , Zhang Yingze 
Published: July 2024

Background:
The optimal duration for surgical antibiotic prophylaxis (SAP) for preventing surgical site infection (SSI) in orthopaedic surgeries remains poorly supported by high-level evidence. This study aimed to assess the association between SAP duration and the occurrence of SSI within one year postoperatively.

Methods:
This prospective cohort study was based on the database from Surgical Site Infection Surveillance and Improvement Project (SISIP) of a tertiary orthopaedic university hospital from October 2014 to December 2020. The main outcome was SSI, defined according to the CDC/NHSN criteria, determined by a review of index hospitalization medical records, microbiology laboratory reports, and readmission records for SSI treatment within one year after discharge. Adjusted generalized additive models (GAMs) were performed to assess the relationships between SAP duration and SSI, determine the cut-off point of SAP duration, and estimate the relative contribution of each included variable across the overall cohort and the three subgroups (open fracture, closed fracture, and non-traumatic group). Multivariable logistic regression models were used to estimate the association between prolonging SAP duration based on the cut-off point and SSI.

Results:
There were 37 046 patients (55.1% male) included, with an overall SSI incidence of 2.35% (871/37 046). In adjusted GAMs, no statistically significant relationships were observed in the overall cohort and open or closed group (P>0.05), but a non-linear relationship was exhibited in the non-traumatic group (P=0.03); the cut-off point was 2.4 days for the overall cohort and 3.6 days (open), 2.6 days (closed), 1.1 days (non-trauma) for three subgroups. In adjusted logistic regression, prolonging SAP duration did not demonstrate a statistically significant protective effect in overall cohort (aOR=0.868; 95% CI, 0.746–1.011) and three groups (open: aOR=0.867; 95% CI, 0.668–1.124; closed: aOR=0.925; 95% CI, 0.754–1.135; non-trauma: aOR=1.184; 95% CI, 0.832–1.683). The relative contribution ranks of SAP duration were 21st overall among 34 factors, 14th for open fractures, 28th for closed fractures, and 3rd for the non-traumatic group among 33 factors.

Conclusion:
Prolonged postoperative SAP duration has no protective effect against SSI in orthopaedic surgery. Our findings support current guidelines against the practice of continuing SAP postoperatively.
Oncological survival in pancreatic head ductal carcinoma: hybrid minimally invasive versus open pancreatoduodenectomy – a single centre analysis
Authors: Lettner Johannes D. , Kuesters Simon , Fichtner-Feigl Stefan , Biesel Esther A. , Chikhladze Sophia , Wittel Uwe A. 
Published: July 2024

Background:
Surgery remains the only curative treatment option for pancreatic head cancer. Laparoscopic surgical techniques are increasingly used, in line with the development of visceral surgery as a whole. The success of surgery is measured by the oncological outcome. Aim of this study is to evaluate the oncological outcome and survival after laparoscopic assisted resection of the pancreatic head compared to open surgery for ductal adenocarcinoma.

Materials and methods:
Data were collected in a prospectively maintained database. Perioperative and oncological outcomes of 182 laparoscopic pancreatic head resections for ductal carcinoma were compared with 585 open pancreatic head resections. The laparoscopic procedures were performed between 2010 and 2022, the open procedures between 2002 and 2022.

Results:
Laparoscopic procedure was significantly superior in terms of intraoperative blood loss (575 vs. 600 ml, P=0.021) and operative time (413 vs. 427 min, P=0.033). Tumor size (25 vs. 27 mm, P=0.028), need for portal vein resection (P=0.009) and blood transfusion (P=0.004) were significantly greater in the open group (P=0.009). The resection margin remained negative significantly more often in the laparoscopic group (159 [87%] vs. 449 [77%], P<0.001). There was no difference in postoperative mortality and morbidity. Postoperative survival at 5 years was significantly better in the laparoscopic group (37 vs. 15%, P<0.001).

Conclusions:
In our cohort, patients who underwent hybrid laparoscopic resection of pancreatic head cancer showed a significantly improved oncological outcome. Most of these effects are due to selection bias, which is not captured by the clinical parameters used to date. Our results highlight the need for additional prognostic factors in pancreatic cancer.
The role of adjuvant chemotherapy after radical surgery in patients with lymph node-positive bladder cancer or locally advanced (pT3, pT4a) bladder cancer: a meta-analysis and systematic review
Authors: Chen CaiXia , Wang ChongJian , Huang HaoTian , Li HongYuan , Wen Zhi , Liu Yang , Yang Xue-song 
Published: July 2024

Purpose:
This study aims to evaluate the impact of adjuvant chemotherapy (AC) on survival outcomes in patients with lymph node-positive bladder cancer or locally advanced (pT3, pT4a) bladder cancer after surgery. The authors also seek to identify which patients with pN+ bladder cancer are most likely to benefit from AC after radical cystectomy (RC).

Methods:
The authors searched databases including Embase, PubMed, Cochrane, and ClinicalTrials.gov to identify relevant literature published in English up to February 2024. The authors used Stata to compare various parameters. The study has been registered in PROSPERO.

Results:
A total of 21 studies were analyzed, including 1 randomized controlled trial, 6 prospective studies, and 14 retrospective studies, encompassing 12 888 patients. The meta-analysis showed that for patients with lymph node-positive bladder cancer, the AC group had higher overall survival (OS) [I
2=58.2%, hazard ratio (HR) 0.69; 95% CI: 0.57–0.83; P=0.019] and recurrence-free survival (I
2=66.6%, HR 0.71; 95% CI: 0.57–0.89; P=0.006) compared to the RC group. For patients with pT3 and pT4a bladder cancer, the AC group had higher OS (I
2=57.3%, HR 0.77; 95% CI: 0.67–0.89; P=0.022) and cancer-specific survival (I
2=47.2%, HR 0.75; 95% CI: 0.64–0.88; P=0.0048) compared to the RC group. At the same time, according to the different chemotherapy regimens, the authors divided the cisplatin-based chemotherapy regimen and carboplatin-based chemotherapy or other regimens into two subgroups for analysis, and found that the OS (I
2=41.4%, HR 0.64; 95% CI: 0.51–0.80; P=0.000) was better than carboplatin and other chemotherapy regimens (I
2=64.1%, HR 0.77; 95% CI: 069–0.86; P=0.000); lymph node density was found to be an independent predictor of OS (HR=1.6; 95% CI: 1.31–1.95; P=0.0000).

Conclusion:
This study found that postoperative AC improves OS, cancer-specific survival, and recurrence-free survival in patients with pT3, pT4a. It was also confirmed that cisplatin-based chemotherapy regimen was more beneficial for patients with bladder cancer; and lymph node-positive bladder cancer. Additionally, our analysis revealed that patients with lymph node-positive bladder cancer benefit more from postoperative AC. It was further demonstrated that cisplatin-based chemotherapy regimens are more beneficial than other regimens for patients with locally advanced bladder cancer.