bluuebunny/crossref_metadata_2025_split huggingface dataset:
Free cortisol and free 21-deoxycortisol in the clinical evaluation of congenital adrenal hyperplasia
Authors: Adriaansen Bas P.H. , Utari Agustini , Olthaar André J. , van der Steen Rob C.B.M. , Pijnenburg-Kleizen Karijn J. , Berkenbosch Lizanne , Span Paul N. , Sweep Fred C.G.J. , Claahsen-van der Grinten Hedi L. , van Herwaarden Antonius E. 
Published: July 2024

AbstractContextSome patients with classic congenital adrenal hyperplasia (CAH) survive without glucocorticoid treatment. Increased precursor concentrations in these patients might lead to higher free (biological active) cortisol concentrations by influencing the cortisol-protein binding. In 21-hydroxylase deficiency (21OHD), the most common CAH form, accumulated 21-deoxycortisol (21DF), a precursor steroid, may further increase glucocorticoid activity. Both mechanisms could explain the low occurrence of symptoms in some untreated classic CAH patients.ObjectiveEstablishment and validation of an LC-MS/MS method for (free) cortisol and (free) 21DF to quantify these steroids in untreated patients with classic CAH (n=29), non-classic CAH (NCCAH, n=5), other forms of adrenal insufficiency (AI, n=3), and controls (n=11) before and 60 minutes after Synacthen® administration.ResultsUnstimulated total cortisol levels of untreated classic CAH patients (median 109 nmol/L) were lower compared to levels in untreated NCCAH patients (249 nmol/L, p=0.010) and controls (202 nmol/L, p=0.016), but free cortisol concentrations were similar. Basal free 21DF levels were high in 21OHD patients (median 5.32 nmol/L) and undetectable in AI patients and controls (<0.19 nmol/L). After Synacthen® administration, free concentrations of 21DF -but not cortisol-increased only in patients with 21OHD.ConclusionsFree cortisol levels were similar in classic CAH compared to controls and NCCAH patients, suggesting a comparable availability of cortisol. Additionally, 21OHD patients produce high levels of the glucocorticoid 21DF, possibly explaining the low occurrence of symptoms in some classic 21OHD patients. Free cortisol and (free) 21DF levels should be considered in the clinical evaluation of adrenal insufficiency in patients with CAH.
Does motivation differ across generations? A two-wave study
Authors: Kothari Tanvi Paras , Pingle Sameer Sudhakar , Karani Mehta Anushree 
Published: July 2024

PurposeThe main objective of the study was to understand the impact of intrinsic and extrinsic motivation on productivity at two different times: before and after the pandemic era, among middle and top-level professionals across India.Design/methodology/approachThe study has adopted a shortitudinal approach. The data were collected two times from the same respondents: before the pandemic (T1) and after the pandemic (T2) following the convenience sampling. At T1, we received responses from 321 respondents. At T2, we received only 203 responses while contacting the same respondents. Thus, the final sample size was only 203 respondents.FindingsThe results revealed that in the pre-pandemic times, both intrinsic and extrinsic motivation impacted the productivity of middle and top-level professionals. Further, the study also revealed that only intrinsic motivation impacted productivity after the pandemic. Moreover, generational cohorts (pre-liberalization, early-liberalization and rapid growth generations) moderated the relationship between intrinsic and extrinsic motivation and Productivity at T1 and T2.Research limitations/implicationsWoven in the multiple theories, the study has some practical and theoretical nuances. The intrinsic and extrinsic motivations were rooted in the self-determination theory. The results also supported that extrinsic reward cannot increase intrinsic motivation in difficult times, and only intrinsic motivation is constant at all times, contributing to productivity. The HR department should understand the importance of intrinsic motivation and design employee benefits and policies.Practical implicationsThe results also supported that extrinsic reward cannot increase intrinsic motivation in difficult times, and only intrinsic motivation is constant at all times, contributing to productivity. The HR department should understand the importance of intrinsic motivation and design employee benefits and policies.Originality/valueFollowing the generational view, the study added that different generation reacts differently to the turbulent times.
The effect of early life care on childhood cognitive development in Ghana
Authors: Ofori Adofo Josephine 
Published: July 2024

PurposeIn most Sub-Saharan African countries, a widely adopted policy to increase access to healthcare is the complete or partial removal of health user fees. This paper examines the effect of removing health user fees on the cognitive development of children in Ghana.Design/methodology/approachThe study uses the Ghana Socioeconomic Panel Survey (GSPS) and a difference-in-differences method to analyze the impacts of free healthcare.FindingsThe findings show that improved access to healthcare enhances the cognitive ability of children. More importantly, children who received free healthcare in early life experienced significant improvement in their cognitive ability. The benefits are also huge for girls and children from low-income families. The findings further show that maternal health, the timely receipt of vaccinations and regular infant health visits are important operative channels through which improved access to healthcare affects children’s cognitive ability.Originality/valueThere are several studies on the effects of eliminating health user fees on various outcomes, but only a few focus on children’s outcomes. This study contributes to the literature by focusing on a vital child outcome, cognitive ability and exploring the timing and pathways through which abolishing health user fees affect cognitive development in children. Because cognitive ability is crucial for educational and labor market outcomes, the findings are useful for policymakers in determining the population to target and the timing of interventions that yield huge impacts when designing health intervention programs in developing countries.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-11-2022-0739.
CEO social media celebrity status and credit rating assessment
Authors: Fang Yue , Bao Xin , Sun Baiqing , Lau Raymond Yiu Keung 
Published: July 2024

PurposeThis paper aims to investigate the effect of CEO social media celebrity status on credit ratings and to determine whether potential threats on the CEO celebrity status negatively moderate the above association.Design/methodology/approachThe authors collected tweets for 874 CEOs from 513 unique S&P 1500 firms. A panel data analysis was conducted on a panel with 4,235 observations from 2009 to 2020. We then tested the hypothesis with the ordinal logit model.FindingsThe empirical findings confirmed that CEO social media celebrity status is positively associated with corporate credit rating outcomes. Our path analyses revealed that CEOs with higher social media celebrity status have less incentive to conduct risk-taking behaviors and thus benefit credit ratings. When the rating agencies perceive potential threats to CEO celebrity status, including CEO myopia and CEO overconfidence, the association between CEO social media celebrity status and credit rating is weakened.Practical implicationsThis study provides an in-depth understanding of CEO social media perception on credit ratings for firms' managers and capital market participants. Findings can help managers and firms improve their strategies for leveraging social media to release credit constraints. The debt market participants could adopt the CEO social media celebrity status and its concerned threats to setting debt contracts with an adequate price.Originality/valueThis is likely to be the first study that examines the effect of CEO social media celebrity status on credit ratings. The findings of this study also reveal that social media certificated celebrity CEOs tend to be capable of enhancing firm revenue and have lower risk-taking incentives, unlike mass media certificated celebrity CEOs.
Bricolage and the entrepreneurial process in times of crisis: insights from new ventures in the Philippines
Authors: Francisco Jamil Paolo 
Published: July 2024

Purpose
How does entrepreneurship flourish amidst persistent resource scarcity, market imperfections, underdeveloped infrastructure and institutional voids? In recent years, bricolage has emerged in the entrepreneurship literature as an effective form of resource mobilization in resource-constrained environments and crisis situations. The purpose of this study is to investigate the role of bricolage in new venture creation by examining the use of bricolage at each stage of the entrepreneurial process of opportunity discovery, development and exploitation.

Design/methodology/approach
The author conducted a qualitative analysis of 10 new business ventures established in the Philippines during the COVID-19 pandemic.

Findings
The author found a prevalence of bricolage at every stage of the entrepreneurial process in all cases, showing that bricolage was embedded in the behavior and decision-making of entrepreneurs throughout the process.

Practical implications
The finding have implications for policymakers aiming to support entrepreneurship in emerging economies.

Originality/value
This paper contributes to the literature by providing empirical evidence of bricolage behavior identified at every step of the entrepreneurial process in a specific emerging economy context.
AI adoption in supply chain management: a systematic literature review
Authors: Shahzadi Gulnaz , Jia Fu , Chen Lujie , John Albert 
Published: July 2024

PurposeThis systematic literature review (SLR) aims to critically analyze the current academic research on the adoption of artificial intelligence (AI) in supply chain management (SCM) and develop a theoretical framework and future research agenda.Design/methodology/approachThrough a comprehensive review of 68 relevant papers, this study synthesizes the findings to identify key themes based on extended technology-organization-environment (TOE) theory.FindingsThis study analyzes AI integration in SCM based on the TOE framework, identifying drivers (technological, organizational, environmental and human), barriers (technical, organizational, economic and human) and outcomes (operational, environmental, social and economic) of AI adoption. It emphasizes AI's potential in improving SCM practices like resilience, process improvement and sustainable operations, contributing to better decision-making, efficiency and sustainable practices. The study also provided a novel framework that offers insights for strategic AI integration in SCM, aiding policymakers and managers in understanding and leveraging AI's multifaceted impact.Originality/valueThe originality of the study lies in the development of a theoretical framework that not only elucidates the drivers and barriers of AI in SCM but also maps the operational, financial, environmental and social outcomes of AI-enabled practices. This framework serves as a novel tool for policymakers and managers, offering specific, actionable insights for the strategic integration of AI in supply chains (SCs). Furthermore, the study's value is underscored by its potential to guide policy formulation and managerial decision-making, with a focus on optimizing SC efficiency, sustainability and resilience through AI adoption.
Publication performance and trends in psychological capital research: a bibliometric analysis
Authors: Pham Van-Chien , Wong Wing-Keung , Bui Xuan Thi 
Published: July 2024

PurposeThis research aims to provide a comprehensive understanding of the evolution and trends in psychological capital (PsyCap) research and related issues.Design/methodology/approachThis research uses bibliometric analysis. A total of 2,244 journal articles were extracted from the Scopus database using relevant keywords, covering the period from 1997 to 2023. The data analysis was conducted utilizing VOSviewer software, Microsoft Excel, and an online text analysis tool.FindingsThere is a rapid rise in the quantity of PsyCap publications, especially from 2017, with significant contribution of research from Chinese scholars with 577 articles in the period 2019–2023. The antecedents of PsyCap have a stagnation of leadership-related topics and increased focus on social support and perceived organizational support. The attention has been specifically directed toward well-being and mental health, with special emphasis on work engagement, job satisfaction, and job performance.Research limitations/implicationsThe exclusion of certain publications in this research may overlook emerging trends. Thus, future research endeavors should adopt a multifaceted approach that combines bibliometric analysis with qualitative and quantitative methods to glean comprehensive insights into PsyCap research.Originality/valuePsyCap research is growing rapidly, with more publications in the last three years than in all the previous years combined. This study, updating data until the end of 2023, provides the most up-to-date insights on research trends in PsyCap to aid scholars in discerning suitable avenues for their research endeavors.
Multi-stakeholder recommendations system with deep learning-based diversity personalization and multi-objective optimization for establishing trade-off among competing preferences
Authors: Shrivastava Rahul , Sisodia Dilip Singh , Nagwani Naresh Kumar 
Published: July 2024

PurposeThe Multi-Stakeholder Recommendation System learns consumer and producer preferences to make fair and balanced recommendations. Exclusive consumer-focused studies have improved the recommendation accuracy but lack in addressing producers' priorities for promoting their diverse items to target consumers, resulting in minimal utility gain for producers. These techniques also neglect latent and implicit stakeholders' preferences across item categories. Hence, this study proposes a personalized diversity-based optimized multi-stakeholder recommendation system by developing the deep learning-based diversity personalization model and establishing the trade-off relationship among stakeholders.Design/methodology/approachThe proposed methodology develops the deep autoencoder-based diversity personalization model to investigate the producers' latent interest in diversity. Next, this work builds the personalized diversity-based objective function by evaluating the diversity distribution of producers' preferences in different item categories. Next, this work builds the multi-stakeholder, multi-objective evolutionary algorithm to establish the accuracy-diversity trade-off among stakeholders.FindingsThe experimental and evaluation results over the Movie Lens 100K and 1M datasets demonstrate that the proposed models achieve the minimum average improvement of 40.81 and 32.67% over producers' utility and maximum improvement of 7.74 and 9.75% over the consumers' utility and successfully deliver the trade-off recommendations.Originality/valueThe proposed algorithm for measuring and personalizing producers' diversity-based preferences improves producers' exposure and reach to various users. Additionally, the trade-off recommendation solution generated by the proposed model ensures a balanced enhancement in both consumer and producer utilities.
Exploring consumer engagement and satisfaction in health and wellness tourism through text-mining
Authors: Balcioglu Yavuz Selim 
Published: July 2024

PurposeThis study aims to deepen the understanding of consumer engagement and satisfaction within the health and wellness tourism sector, a rapidly growing niche in the global tourism industry. It focuses on identifying key elements that influence consumer perceptions and experiences in this domain.Design/methodology/approachEmploying a quantitative approach, this research utilizes Dynamic Correlated Topic Models (DCTM) and sentiment analysis techniques to analyze user-generated content from TripAdvisor. The methodology involves parsing through extensive online reviews to extract thematic patterns and emotional sentiments related to various wellness tourism experiences.FindingsThe findings reveal that wellness and relaxation, spa and therapy services, and cultural immersion are significant factors influencing consumer satisfaction in health and wellness tourism. These elements contribute to a more profound and emotionally satisfying tourist experience, highlighting the shift from traditional tourism to more holistic, wellness-focused travel.Research limitations/implicationsThe study is limited by its focus on user-generated content from a single platform, which may not fully represent the diverse range of consumer experiences in health and wellness tourism. Future research could expand to include other platforms and cross-reference with qualitative data.Practical implicationsThe study offers valuable implications for destination managers and marketers in the health and wellness tourism industry, suggesting that enhancing and promoting wellness-centric experiences can significantly improve consumer satisfaction and engagement.Social implicationsThe research underscores the growing importance of health and wellness in societal values, reflecting a shift in consumer preferences towards travel experiences that offer mental, physical, and spiritual benefits. This has broader implications for how destinations can cater to the evolving demands of socially conscious travelers.Originality/valueThis research contributes original insights into the evolving field of health and wellness tourism by integrating advanced text mining techniques to analyze consumer feedback, offering a novel perspective on what drives engagement and satisfaction in this sector.
Commentary on “Stakeholder experiences of deprescribing psychotropic medicines for challenging behaviour in people with intellectual disabilities”
Authors: Clifford Adam , Omokanye Mariam , Bagalkote Deval 
Published: July 2024

Purpose
This paper aims to provide a commentary response to “Stakeholder experiences of deprescribing psychotropic medicines for challenging behaviour in people with intellectual disabilities”.

Design/methodology/approach
The commentary provides some evidence-based perspectives on the risks and challenges of psychiatric drug-withdrawal, emphasising the importance of the patient experience in deprescribing decisions. It also makes the case for clinical clarity and carer-engagement in optimising deprescribing outcomes for individuals. Some clinical reflections are provided.

Findings
Whilst efforts to reduce the overmedication of people with learning disabilities are welcomed, there is lacking evidence around this population’s experience of adverse effects from psychiatric deprescribing decisions, including differentiating between withdrawal and relapse effects. Clinical clarity and carer engagement are key to safe and effective prescribing, although in reality, this can be challenging.

Originality/value
This paper will be of value to all professionals with a role in the effective deprescribing of psychiatric medications with and/or for people with intellectual disability. It provides perspectives on aspects of stakeholder experience that warrant further consideration and research.
Evaluation of the extended Japan NBI expert team classification of subtype 2B in laterally spreading colorectal tumors based on blue laser imaging
Authors: Zheng Lin Fu , Chen Long Ping , Zhou Lin Xin , Zheng Jin , Jiang Chuan Shen , Peng Shi Rui , Li Da Zhou , Wang Wen 
Published: July 2024

ObjectivesThe Japan NBI Expert Team (JNET) classification has good diagnostic potential for colorectal diseases. We aimed to explore the diagnostic value of the JNET classification type 2B (JNET2B) criteria for colorectal laterally spreading tumors (LSTs) based on magnifying endoscopy with blue laser imaging (ME‐BLI) examination.MethodsBetween January 2017 and June 2023, 218 patients who were diagnosed as having JNET2B‐type LSTs using ME‐BLI were included retrospectively. Endoscopic images were reinterpreted to categorize the LSTs as JNET2B‐low (n = 178) and JNET2B‐high (n = 53) LSTs. The JNET2B‐low and JNET2B‐high LSTs were compared based on their histopathological and morphological classifications.ResultsAmong the 178 JNET2B‐low LSTs, 86 (48.3%) were histopathologically classified as low‐grade intraepithelial neoplasia, 54 (30.3%) as high‐grade intraepithelial neoplasia (HGIN), 37 (20.8%) as intramucosal carcinoma (IMC), and one (0.6%) as superficial invasive submucosal carcinoma (SMC1). Among the 53 JNET2B‐high LSTs, five (9.4%) were classified as HGIN, 28 (52.9%) as IMC, 15 (28.3%) as SMC1, and 5 (9.4%) as deep invasive submucosal carcinoma. There were significant differences in this histopathological classification between the two groups (P < 0.001). However, there was no significant difference between JNET2B‐low and JNET2B‐high LSTs based on their morphological classification (granular vs nongranular) or size (<20 mm vs ≥20 mm). Besides, the κ value for JNET2B subtyping was 0.698 (95% confidence interval 0.592–0.804) between the two endoscopists who reassessed the endoscopic images.ConclusionThe JNET2B subtyping of LSTs has a diagnostic potential in the preoperative setting, and may be valuable for treatment decision‐making.
The efficacy of almonertinib and anlotinib combination therapy for advanced non‐small‐cell lung cancer patients who continued to experience cancer progression during third‐generation EGFR‐TKI treatment: a retrospective study
Authors: Zhang Yu , Wang Chengmeng , Zhao Jing , Wang Meng 
Published: July 2024

AbstractBackgroundEpidermal growth factor receptor (EGFR) mutations are key drivers in a significant portion of non‐small‐cell lung cancer (NSCLC) patients. While third‐generation EGFR‐tyrosine kinase inhibitors (TKIs) such as osimertinib have demonstrated efficacy, the management of patients who continue to experience disease progression during treatment remains challenging. The emergence of drug resistance, including the development of secondary mutations, necessitates exploration of alternative treatment strategies. This study aims to evaluate and observe the efficacy and safety of almonertinib combined with anlotinib in patients after cancer progression during third‐generation EGFR‐TKI therapy.MethodsIn this retrospective analysis, we included EGFR‐mutated NSCLC patients who were resistant to third‐generation EGFR‐TKIs. All patients were treated with almonertinib combined with anlotinib. The clinical characteristics, treatment history, clinical benefits, and adverse events of these patients were retrospectively collected.ResultsA total of 16 eligible patients were included in the analysis. The results revealed that combination therapy with almonertinib and anlotinib was effective in this patient cohort. The overall response rate was 25% and the disease control rate was 93.75%. The 6 and 12 months of PFS rates were 92.9% (95% confidence interval [CI] 80.3%, 100.0%) and 84.4% (95% CI 66.6%, 100.0%), respectively. Moreover, this combination therapy was generally well‐tolerated, with manageable adverse events.ConclusionOur retrospective analysis suggests that almonertinib and anlotinib combination therapy may represent a viable option for EGFR‐mutated NSCLC patients who have progressed on third‐generation EGFR‐TKIs, especially for those with posterior lines and no standard treatment options. Further investigation and larger clinical trials are warranted to validate these observations and refine treatment guidelines.