bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing Outcomes in Alzheimer's Disease: Exploring the Effects of a Diversified Rehabilitation Program Combined with Donepezil on Apathy, Cognitive Function, and Family Caregiver Burden
Authors: Ji Xiaoxia , Liang Lihua 
Published: August 2024

Background and objective: Alzheimer's disease is a progressive neurodegenerative disorder characterized by cognitive decline, behavioral changes, and functional impairments. Apathy, a common symptom in Alzheimer's disease, refers to a lack of motivation, interest, and emotional responsiveness. It can significantly impact patients' quality of life and increase caregiver burden. This study aimed to determine the effects of a diversified rehabilitation program combined with donepezil on apathy, cognitive function, and family caregiver burden of Alzheimer's disease patients.
Methods: A total of 105 Alzheimer's disease patients treated at our hospital between January 2020 and January 2023 were selected and analyzed retrospectively. They were assigned to the control group (n = 50) or the observation group (n = 55). The two groups did not differ in terms of general data such as age and sex. All patients were treated with donepezil orally. The control group was given routine nursing, whereas the observation group was given a diversified rehabilitation program intervention, including cognitive training and emotional support. The Hasegawa's dementia scale, mini-mental state examination, and Montreal cognitive assessment scale were adopted to evaluate the cognitive function of the two groups before and after treatment. A caregiver burden scale, the Zarit Burden Interview (ZBI) and the Apathy Evaluation Scale Informant version (AES-I) were used to evaluate the caregiver burden and apathy of the two groups.
Results: A significantly higher overall response rate to treatment was found in the observation group (94.55%) than in the control group (80.00%) (p = 0.024). After treatment, scores on the Hasegawa's dementia scale, mini-mental state examination, and Montreal cognitive assessment scale of the two groups increased to varying degrees, with greater increases in the observation group than in the control group (p < 0.05). The ZBI and AES-I scores of the two groups decreased to different degrees after treatment, with greater decreases in the observation group than in the control group (p < 0.05).
Conclusion: A diversified rehabilitation program combined with donepezil can substantially alleviate the apathy of Alzheimer's disease patients, improve their cognitive function, and reduce the burden on their families.
The Impact of Combined Application of Donepezil and Nimodipine on Patients with Comorbid Cerebral Small Vessel Disease and Cognitive Dysfunction: Efficacy and Influence on Nutritional Status
Authors: Sun Lu , Ma Linqing , Ren Liyan 
Published: August 2024

Background and objective: Cerebral small vessel disease (CSVD) often coexists with cognitive dysfunction in patients, leading to significant challenges in treatment and management. This study aimed to examine the efficacy of combined application of donepezil and nimodipine on patients with comorbid CSVD and cognitive dysfunction and the effects on patients' albumin and prealbumin levels.
Methods: The records of 112 patients with comorbid CSVD and cognitive dysfunction treated at the People's Hospital of Suzhou New District from January 2019 to December 2022 were analysed retrospectively. A total of 50 patients receiving donepezil were allocated to the control group, and 62 patients receiving both nimodipine and donepezil to the study group. Outcomes compared between the two groups included serum homocysteine (Hcy), high sensitivity C-reactive protein (hs-CRP), albumin, and prealbumin before and after therapy, efficacy, and adverse reactions. Additionally, logistic regression was performed to analyze the risk factors impacting patient prognosis.
Results: Prior to therapy, the two groups did not differ significantly in Hcy and hs-CRP levels (p > 0.05), whereas after therapy, the levels in both groups dropped significantly (p < 0.01), with more obvious lower levels in the study group (p < 0.05). After treatment, the study group presented significantly higher albumin and prealbumin levels than the control group (p < 0.001). An obvious higher overall response rate was observed in the study group compared to the control group (p = 0.012). No significant inter-group discrepancy was found regarding the total incidence of adverse reactions (p = 0.752). Univariate analysis identified age, course of disease, heart rate (HR), Montreal Cognitive Assessment (MoCA) score, diastolic blood pressure (DBP), systolic blood pressure (SBP), drinking history, as well as medication regimen as risk factors impacting patient prognosis. Multivariate logistic regression analysis identified SBP, DBP, and medication regimen as the independent risk factors.
Conclusion: Combined application of donepezil and nimodipine can effectively treat patients with comorbid CSVD and cognitive dysfunction. It can significantly lower the Hcy and hs-CRP levels and improve the nutritional status without increasing the frequency of adverse reactions. In addition, for CSVD patients with cognitive dysfunction, age, course of disease, MoCA score, HR, SBP, DBP, drinking history, and medication regimen are risk factors impacting patient prognosis, while SBP, DBP, and medication regimen are independent risk factors.
Predictors of Psychiatric Complications in Patients with Pancreatic Cancer: A Retrospective Cohort Study
Authors: Liu Lewei , Chen Shuo 
Published: August 2024

Background: The relevant survey has shown a high incidence of psychiatric complications in patients with pancreatic cancer. While some studies have explored the factors influencing psychological complications in pancreatic cancer patients, some factors validated in other populations have not been confirmed in the pancreatic cancer population. This study aims to explore the predictors of psychiatric complications in patients with pancreatic cancer.
Methods: Patients with pancreatic cancer admitted to Yueqing People's Hospital Affiliated to Wenzhou Medical University, from January 2021 to January 2022 were retrospectively analyzed. The structured clinical interview (SCID-I) based on Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) was used by nurses to assess the incidence of psychiatric complications during hospitalization (baseline) and 3 months after the start of treatment. Binary logistic regression was used to identify predictors of psychiatric complications.
Results: 80 patients were enrolled in this study and 8 patients were diagnosed with psychiatric complications at base line. Among the rest 72 patients, 8 patients (11.11%) had new-onset psychiatric complications at 3-month follow-up. Gender (Odds Ratio (OR) = 1.674, p = 0.019), monthly income (OR = 1.735, p = 0.023) and sadness (M.D. Anderson Symptom Inventory (MDASI)) (OR = 1.804, p = 0.001) were all predictors for psychiatric complications in patients with pancreatic cancer.
Conclusions: Gender, monthly income and MDASI score are predictors of psychiatric complications in patients with pancreatic cancer.
Application of Psychotherapy Based on Five-Element Theory in Traditional Chinese Medicine in Improving the Mental States of Patients with Post-Stroke Depression
Authors: Xie Lixia , Zi Yaling 
Published: August 2024

Background: This study aims to explore the clinical effect of psychotherapy based on five-element theory in traditional Chinese medicine (TCM) in improving the mental states of patients with post-stroke depression (PSD), to provide reference and guidance for clinical treatment.
Methods: A retrospective study was conducted on 163 PSD cases treated in The Second Affiliated Hospital, Hengyang Medical School, University of South China from January 2022 to January 2023. The patients treated with conventional treatment were included in the control group (n = 84), and patients receiving psychotherapy based on five-element theory in TCM and conventional treatment were classified as the observation group (n = 79). The anxiety levels, depression levels, TCM syndrome scores and sleep quality were compared in both groups. The enumeration data were tested by χ2 test. Kolmogorov-Smirnov method tested whether the measurement data met normal distribution, and those did not meet normal distribution were tested by Mann-Whitney method. The difference was statistically significant at p < 0.05.
Results: After 4-week and 8-week treatments, the observation group had significantly lower scores of Hamilton Anxiety Scale (z = –4.562, –6.765; p < 0.001), Hamilton Depression Scale (z = –7.588, –8.023; p < 0.001), TCM syndrome (z = –7.138, –10.946; p < 0.001), and Pittsburgh sleep quality index (z = –6.819, –8.240; p < 0.001) than the control group.
Conclusion: Psychotherapy based on five-element theory in TCM is beneficial to patients with PSD and can bring a certain clinical reference value.
The Effectiveness of Micro-credential Programme from the Perspective of Tourism Students
Authors: Azmi Azila , Zubir Hanani Ahmad , Farook Ferial , Noorafizi Hamizah , Wahab Ahmad Mu’az Abd 
Published: August 2024

Tourism micro-credential programmes have gained significant attention in recent years as a means of enhancing the skills and knowledge of students pursuing careers in the tourism industry. However, it is important to evaluate the effectiveness of these programmes from the perspective of tourism students at various universities in Malaysia. These digital proofs of learning serve as evidence of the learner's achievements, knowledge, and experience, which can be utilised to progress towards a more comprehensive certification or degree that focuses on a specific topic of study within a shorter time. Despite the increasing use of this platform in recent years, there are limited studies discussing its impact on students' perceptions and its effectiveness in enhancing their engagement with tourism subjects. Thus, this research was conducted to determine the effectiveness of the micro-credential programmes from the perspective of tourism students so that they can be managed more effectively in higher education institutions. To obtain data, the qualitative technique of interpretive phenomenological analysis (IPA) was applied to thoroughly examine the participants’ actual experiences. The participants were selected among the tourism students from various universities in Malaysia that offer tourism and hospitality courses. The interview data were analysed using thematic analysis, which enabled the identification of four themes and fourteen codes. The findings highlighted that the students have positive experiences following micro-credential programmes. Further research should be carried out to ensure micro-credential programmes stay relevant in a constant tourism industry.
Pemetaan Data Fakir Miskin Di Desa Sidodadi Berbasis Web Dengan Menggunakan Metode Simple Additive Weighting (SAW)
Authors: Wali Ja’far Shudiq  
Published: August 2024

Berbagai program dari bantuan Pemerintah dalam upaya penanggulangan kemiskinan memang telah banyak, tetapi berbagai bantuan yang sampai di tangan rakyat tidak sesuai dengan yang diharapkan serta banyaknya parameter atau indikator kemiskinan mengakibatkan kurang efektifnya program penanganan kemiskinan. Di desa Sidodadi dalam proses pemetaan data fakir miskin masih menggunakan pendataan manual dalam perangkingan fakir miskin yang mendapatkan bantuan, penginputan data serta laporan data masih menggunakan pencatatan pada MS Excel dan dicetak dalam bentuk hardcopy, sehingga memerlukan banyak tempat penyimpanan dan juga memerlukan banyak kertas. Metode perancangan yang digunakan adalah metode waterfall melalui langkah-langkah dimulai dengan analisis sistem lama dengan melakukan wawancara secara langsung dan tidak langsung atau by phone dan memeriksa dokumen-dokumen yang terkait dengan sistem yang dibangun. Sistem Pendukung Keputusan pemetaan data fakir miskin di desa Sidodadi Menggunakan Metode Simple Additive Weighting (SAW). Hasil yang dicapai dalam penelitian ini adalah membangun sistem pemetaan data fakir miskin di desa Sidodadi agar dapat memebantu dan mengatasi permasalahan pada proses penginputan data dan perangkingan data fakir miskin serta mempermudah kepala desa dalam proses pemetaan data fakir miskin dan pelaporan yang sudah berorientasi pada sistem jaringan internet. Kesimpulan yang didapat pada penelitian ini adalah terbangunnya sebuah sistem pemetaan data fakir miskin yang berkualitas dan dapat memperbaiki sistem lama serta memberikan kemudahan dalam proses perangkingan data fakir miskin.
PERSEPSI ULAMA NU BLORA TERHADAP BATAS MINIMAL USIA PERKAWINAN DALAM UU NO 16 TAHUN 2019
Authors: Chumayro Saidatul 
Published: August 2024

This study aims to describe the perceptions of the ulama of Nu Blora regarding the age limit for marriage stipulated in Law No. 16/2019. The emergence of this new provision raises a difference of opinion, especially among the ulama, which basically the provisions for the permissibility of marriage in Islam have reached baligh only without mentioning age. This research was conducted in Blora Regency with descriptive qualitative research and empirical juridical approach. The data was obtained by conducting interviews with Ulama Nu Blora and then describing it by means of data reduction, data presentation, and conclusions. The results obtained are the opinions of ulama who agree, disagree, and moderate ulama (not fully agree and disagree) against the law. Scholars who agree consider the regulation to be very beneficial for the community because in the household there is a need for emotional and financial preparedness. However, not all scholars can accept these rules, there are some who remain principled with Islamic law, namely the principle of baligh. They assume that if the marriage is delayed it is feared that an adultery will occur, especially seeing the promiscuity that occurs in the current era. Then moderate scholars argue that in implementing the law, they must look at the madharat and mashlahat aspects. Based on these results, the author specifically concludes that preparing mentally, physically and materially is very important because when we dare to get married, we are ready to be responsible for our rights and obligations after marriage.
O USO DAS METODOLOGIAS ATIVAS NO ENSINO DE MATEMÁTICA NAS SÉRIES FINAIS DO ENSINO FUNDAMENTAL II DA ESCOLA ESTADUAL RUY ARAÚJO
Authors: Moreira de Alencar José Jorge , Siqueira da Silva José Amauri , Gusmão Lima Suzana 
Published: August 2024

A presente proposta de pesquisa visa apresentar o emprego de metodologias ativas de ensino voltadas ao ensino de matemática de modo tal que venha a propiciar aos alunos situações reais e imaginárias que tenham uma interrelação direta com sua vivência cotidiana. Ressalta-se que tais situações-problemas propostas estejam voltadas a experiência de vida do educando em detrimento da aplicação prática dos conteúdos de Matemática apresentados em sala de aula e uso deste em sua vida cotidiana prática. A proposta de trabalho foi desenvolvida nas turmas 01 e 03 dos 9º anos do Ensino Fundamental da Escola Estadual Ruy Araújo ao longo do ano letivo de 2023 e esta foi aplicada adotando-se o modelo “Qualiquantitativo Projetivo”, recorrendo ao uso das metodologias ativas nas aulas da disciplina de Matemática.” A abordagem temática visou explorar o uso de recursos lúdicos e tecnológicos diversos tendo como um dos principais objetivos foi de favorecer o desenvolvimento das habilidades e competências do educando nas diversas áreas de saberes a qual foi adotada nas turmas de 9º ano primando pela qualidade instrucional embasando-se em orientações recomendadas pela Base Nacional Comum Curricular (BNCC), lançando mão ainda das tecnologias disponíveis e a interação destes com seu contexto de vida. Além disso, observou-se um maior interesse e participação dos alunos durante aulas que fazem uso de metodologias ativas, demonstrando também uma maior compreensão e domínio dos conteúdos apresentados em sala de aula.
AVALIAÇÃO DO PONTO DE CRUZAMENTO DA LINHA DE TUFFIER COM A COLUNA VERTEBRAL NOS USUÁRIOS DE UM HOSPITAL PÚBLICO NO DISTRITO FEDERAL ATRAVÉS DA ULTRASSONOGRAFIA.
Authors: de Macedo Dalla Corte Ludimila , Gonçalves Fleury Bruno Antônio 
Published: August 2024

Introdução: O método palpatório é hoje o mais utilizado para identificação da referência anatômica da linha de Tuffier, descrito na literatura como uma linha imaginária que liga as duas cristas ilíacas, correspondendo ao espaço intervertebral L4-L5 ou apófise de L4. Este seria o espaço considerado seguro para a realização da anestesia subaracnóidea, e da punção lombar, visto que a extremidade caudal da medula espinhal fica situada entre L1-L2 na maioria dos indivíduos adultos. Objetivo: Identificar o espaço intervertebral de correspondência da linha de Tuffier por meio da ultrassonografia, analisando a prevalência deste espaço na população da região metropolitana de Brasília. Método: Trata-se de um estudo transversal e observacional. Com coleta de dados de indivíduos atendidos no Hospital Regional da Asa Norte – HRAN, durante os meses de maio a dezembro de 2022. Foram incluídos no estudo os indivíduos acima de 18 anos atendidos no HRAN. Os dados foram coletados através de formulário digital do Google®, a plataforma possibilita baixar os dados coletados já tabulados em planilhas. Foi realizada análise estatística com construção de tabelas para a exposição dos resultados. Além disso, foi realizada análise estatística analítica para avaliação dos resultados das variáveis categóricas da amostra por meio de testes específicos para tabelas bivariadas. Sendo realizada correlação dos achados ultrassonográficos do nível lombar da linha de Tuffier com as variáveis epidemiológicas levantadas (idade, peso, altura e índice de massa corpórea). Resultados: Durante o período proposto para o estudo (maio a dezembro de 2022) foram avaliados 70 indivíduos atendidos no Hospital Regional da Asa Norte. 65,71% eram do sexo feminino e 34,29% do sexo masculino, a média da idade dos indivíduos foi de 45 anos (19- 83 anos), peso médio de 72 Kg (44-140Kg), altura média de 165cm (147- 194 cm) e índice de massa corpórea médio de 26,23 (18,08-43,56). O espaço IV encontrado no USG com maior frequência foi L3-L4 em 57,14% dos casos. Conclusão: conclui-se que o presente estudo demonstrou concordância com a literatura em relação a grande variação na localização da linha de Tuffier, e em discordância com a literatura o espaço predominante localizado foi em L3-L4.
Pengaruh Kompensasi, Kepuasan Kerja Dan Kemampuan Kerja Terhadap Kinerja Pegawai Di Kantor Pelayanan Pajak Pratama Medan Polonia
Authors: Nanda Ananda Fitriani Dewi , Purwita Sari  
Published: August 2024

Penelitian ini bertujuan untuk mengetahui pengaruh kompensasi, kepuasan kerja dan kemampuan kerja secara parsial dan secara bersamaan terhadap kinerja pegawai di Kantor Pelayanan Pajak Pratama Medan Polonia dengan populasi sebanyak 95 orang, dan sampel penelitian sebanyak 93 orang. Pengumpulan data dilakukan dengan wawancara, kuesioner dan dokumentasi. Teknik analisis data yang digunakan adalah analisis regresi berganda dengan menggunakan program komputer IMB Statistik for Product and Service Solution (SPSS) versi 24. Berdasarkan hasil analisis diperoleh kompensasi berpengaruh positif dan signifikan terhadap kinerja pegawai Kantor Pelayanan Pajak Pratama Medan Polonia, hal ini didukung hasil analisis t hitung > t-tabel (2,938 > 1,987) pada n = 93 pada taraf sifgifikansi 95%. Kepuasan kerja berpengaruh berpengaruh positif dan signifikan terhadap kinerja pegawai Kantor Pelayanan Pajak Pratama Medan Polonia, hal ini didukung analisis t hitung > t-tabel (2,128 > 1,987) pada n = 93 pada taraf signifikansi 95%. Kemampuan kerja berpengaruh positif dan signifikan terhadap kinerja pegawai Kantor Pelayanan Pajak Pratama Medan Polonia, hal ini didukung analisis t hitung > t-tabel (3,335 > 1,987) pada n = 93 dengan taraf sifgnifikan 95%. Nilai F-hitung > F tabel (16,396 > 2,71) hal ini menyatakan bahwa secara bersama-sama (multiple) terdapat pengaruh positif dan signifikan kompensasi, kepuasan kerja dan kemampuan kerja terhadap kinerja pegawai Kantor Pelayanan Pajak Pratama Medan Polonia.

Kata kunci : Kompensasi, Kepuasan Kerja, Kemampuan kerja, kinerja pegawai.
Prediction of PM2.5 concentration based on a CNN-LSTM neural network algorithm
Authors: Bai Xuesong , Zhang Na , Cao Xiaoyi , Chen Wenqian 
Published: August 2024

Fine particulate matter (PM2.5) is a major air pollutant affecting human survival, development and health. By predicting the spatial distribution concentration of PM2.5, pollutant sources can be better traced, allowing measures to protect human health to be implemented. Thus, the purpose of this study is to predict and analyze the PM2.5 concentration of stations based on the integrated deep learning of a convolutional neural network long short-term memory (CNN-LSTM) model. To solve the complexity and nonlinear characteristics of PM2.5 time series data problems, we adopted the CNN-LSTM deep learning model. We collected the PM2.5data of Qingdao in 2020 as well as meteorological factors such as temperature, wind speed and air pressure for pre-processing and characteristic analysis. Then, the CNN-LSTM deep learning model was integrated to capture the temporal and spatial features and trends in the data. The CNN layer was used to extract spatial features, while the LSTM layer was used to learn time dependencies. Through comparative experiments and model evaluation, we found that the CNN-LSTM model can achieve excellent PM2.5 prediction performance. The results show that the coefficient of determination (R2) is 0.91, and the root mean square error (RMSE) is 8.216 µg/m3. The CNN-LSTM model achieves better prediction accuracy and generalizability compared with those of the CNN and LSTM models (R2 values of 0.85 and 0.83, respectively, and RMSE values of 11.356 and 14.367, respectively). Finally, we analyzed and explained the predicted results. We also found that some meteorological factors (such as air temperature, pressure, and wind speed) have significant effects on the PM2.5 concentration at ground stations in Qingdao. In summary, by using deep learning methods, we obtained better prediction performance and revealed the association between PM2.5 concentration and meteorological factors. These findings are of great significance for improving the quality of the atmospheric environment and protecting public health.