bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interim Hydrologic Responses to Phase I of the Kissimmee River Restoration Project, Florida
Authors: Anderson David H. 
Published: May 2014

AbstractHydrologic conditions were evaluated during a 10‐year Interim Period following completion of Phase I of the Kissimmee River Restoration Project and initiation of environmental water releases from upstream to provide adaptive management of flow to the Phase I area. Phase I construction backfilled 13 km of flood control canal C‐38 and redirected flow into 22 km of reconnected river channel. Evaluations focused on five restoration expectations (performance measures) based on pre‐channelization hydrologic data for the Kissimmee River. Environmental releases resulted in more continuous discharge from upstream, but did not affect the magnitude of discharge. After backfilling of C‐38, water levels in the Phase I area varied with discharge and periodically inundated the floodplain. However, the long, annual recession event, characteristic of pre‐channelization, was not reestablished; instead, most Interim Period years had multiple events with shorter durations and faster recession rates. Mean channel water velocity increased during the Interim Period but was not always in the desired range. Hydrologic conditions throughout much of the Phase I area were affected by the backwater effect of the downstream water control structure. Four expectations showed improvements in terms of number of years met; however, none met the expectation targets. The inability to meet expectation targets reflects in part the incomplete or interim status of the restoration project.
Hidden Costs of Passive Restoration
Authors: Zahawi Rakan A. , Reid John L. , Holl Karen D. 
Published: May 2014

AbstractThe first few years of tropical forest restoration can be expensive, especially when applied to expansive areas. In light of this, passive restoration has been recommended as a considerably cheaper or even free alternative. There are, however, both direct and indirect costs associated with passive restoration. First, the longer recovery time that is typically required in passive restoration can be perceived as project failure, especially when compared with nearby active restoration efforts. In the worst‐case scenario, this can lead to the premature termination of a project by a landowner who would like to see more rapid or visible results. Second, passive restoration may be viewed as land abandonment, and in developing nations where land tenure is not always strictly enforced this may invite unanticipated uses, such as ranchers who may unintentionally or intentionally allow livestock to take advantage of the “unused” forage grass, thus setting back recovery efforts. Lastly, passive restoration does have direct financial costs, including material costs for establishing fences and repairing them, and labor costs for site vigilance. These upfront investments may need to be made repeatedly in passive restoration efforts, and for a longer time period than for an active restoration project. Both the direct and indirect costs should be considered prior to choosing passive restoration as a strategy in a particular restoration project.
Induction of Bcl‐xL‐Specific Cytotoxic T Lymphocytes in Mice
Authors: Larsen H. L. , Andersen M. H. , Wandall H. H. , Madsen C. B. , Christensen R. E. , Petersen T. R. , Pedersen A. E. 
Published: May 2014

AbstractThe induction of active immunity against tumour‐associated antigens to prevent relapse of cancer is a promising approach but has so far shown only low efficacy. This low efficacy may in part be due to clonal escape of tumour cell variants by the downregulation of antigen expression or inflammation‐induced dedifferentiation. Identification of novel tumour‐associated antigens that at the same time are essential for continued tumour cell survival is thus critical for the development of active cancer vaccinations. At the same time, identification of novel endogenous murine tumour antigens will help improve preclinical development of cancer immunotherapy. The anti‐apoptotic protein Bcl‐xL has been suggested to be such an essential tumour antigen, but the lack of well‐defined murine epitopes have delayed preclinical studies of Bcl‐xL‐targeting cancer vaccines. Here, we report the identification of two novel murine tumour‐associated epitopes TAYQSFEQV and AFFSFGGAL derived from mouse Bcl‐xL. Dendritic cell (DC)‐based vaccination induced CD8+ T cells capable of producing IFN‐γ upon restimulation with these epitopes. Thus, our data may benefit the design of future immunotherapy strategies by providing a preclinical model for cancer vaccination with an endogenous tumour antigen that can be combined with other cancer treatments.
Possible Role of Toll‐like Receptor‐2 in the Intracellular Survival of Staphylococcus aureus in Murine Peritoneal Macrophages: Involvement of Cytokines and Anti‐Oxidant Enzymes
Authors: Bishayi B. , Bandyopadhyay D. , Majhi A. , Adhikary R. 
Published: May 2014

AbstractEffects of blocking toll‐like receptor‐2 (TLR‐2) on the survival of Staphylococcus aureus (S. aureus) and cytokine production in peritoneal macrophages of Swiss albino mice were analysed. Macrophages were infected with S. aureus in the presence and absence of anti‐TLR‐2 antibody. Tumour necrosis factor‐α (TNF‐α) interleukin‐6 (IL‐6), interferon‐gamma (IFN‐γ), interleukin‐1β (IL‐1β), interleukin‐12 (IL‐12) and interleukin‐10 (IL‐10) concentrations were measured. Expressions of TLR‐2, NF‐κB, MyD 88 were analysed by Western Blot. Expression of TLR‐2 was increased in S. aureus‐infected macrophages with respect to control and was MyD 88 independent. TLR2 blocking significantly reduced TNF‐α, IL‐6, IL‐1β and IL‐10 and increased IFN‐γ and IL‐12 production. Decreased catalase activity and increased superoxide dismutase (SOD) by S. aureus with concomitant increase in H2O2 and nitric oxide (NO) were observed in the case of prior TLR‐2 blocking. To understand whether catalase contributing in the intracellular survival, was of bacterial origin or not, 3‐amino, 1, 2, 4‐triazole (ATZ) was used to inhibit specifically macrophage‐derived catalase. Catalase enzyme activity from the whole staphylococcal cells in the presence of ATZ suggested that the released catalase were of extracellular origin. From the intracellular survival assay, it was evident that pretreatment of macrophages with ATZ reduces the bacterial burden in macrophages when infected with the recovered bacteria only from the anti‐TLR‐2 antibody‐treated macrophages after phagocytosis. Catalase protein expression from the whole staphylococcal cells recovered after phagocytosis also indicated the catalase release from S. aureus. Capturing of S. aureus via TLR‐2 induces inflammatory reactions through activation of NF‐κB‐signalling pathways which was MyD88‐independent.
EINSTEIN AND MYSTICISM
Authors: Bowman Gary E. 
Published: May 2014

AbstractAlbert Einstein deliberately and repeatedly expressed his general religious views. But what were his views of mysticism? His statements on the subject were few, relatively obscure, and often misunderstood. A coherent answer requires setting those statements in historical, cultural, and theological context, as well as examining Einstein's philosophical and religious views. Though the Einstein that emerges clearly rejected supernatural mysticism, his views of “essential” mysticism were—though largely implicit—more nuanced, more subtle, and ultimately more sympathetic than “mere appearance” suggests.
PROSPECTS FOR THE FIELD OF SCIENCE AND RELIGION: AN OCTOPUS VIEW
Authors: Gregersen Niels Henrik 
Published: May 2014

AbstractThe organic unity between the head and the vital arms of the octopus is proposed as a metaphor for science and religion as an academic field. While the specific object of the field is to pursue second‐order reflections on existing and possible relations between sciences and religions, it is argued that several aspects of realism and normativity are constitutive to the field. The vital arms of the field are related to engagements with distinctive scientific theories, specialized philosophy of science, representative theological proposals, and the input from the study of world religions.
SCIENTISTS AND RELIGIOUS COMMUNITIES: INVESTIGATING PERCEPTIONS, BUILDING UNDERSTANDING
Authors: Wiseman Jennifer , Arveson Paul 
Published: May 2014

AbstractThe American Association for the Advancement of Science (AAAS) Dialogue on Science, Ethics, and Religion (DoSER) program has embarked on an exciting project, “Scientists and Religious Communities: Investigating Perceptions to Build Understanding.” The project will provide the first quantitative data on the underlying assumptions and concerns that shape national attitudes on science. A nationally representative survey conducted in collaboration with sociologists at Rice University has reached 10,000 people, including evangelical Christians, mainline Protestants, Catholics, and Jews. The survey probed how a broad range of religious people, particularly evangelical Christians, understands and thinks about science, and what they perceive about scientists. Scientists, broadly defined, were likewise surveyed to gauge their perceptions of how religious people regard science. The goal for AAAS is to increase understanding between the scientific and evangelical Christian communities and redefine this critical relationship. DoSER will bring together leaders from scientific and evangelical communities to discuss the implications of survey results and to use them for building better understanding and communication strategies. Building relationships between scientists and religious communities has the potential to create a new paradigm of understanding. Finding out what each group actually thinks, through a survey, is only the beginning.
Altered Oral Viral Ecology in Association with Periodontal Disease
Authors: Ly Melissa , Abeles Shira R. , Boehm Tobias K. , Robles-Sikisaka Refugio , Naidu Mayuri , Santiago-Rodriguez Tasha , Pride David T. 
Published: May 2014

ABSTRACTThe human oral cavity is home to a large and diverse community of viruses that have yet to be characterized in patients with periodontal disease. We recruited and sampled saliva and oral biofilm from a cohort of humans either periodontally healthy or with mild or significant periodontal disease to discern whether there are differences in viral communities that reflect their oral health status. We found communities of viruses inhabiting saliva and the subgingival and supragingival biofilms of each subject that were composed largely of bacteriophage. While there were homologous viruses common to different subjects and biogeographic sites, for most of the subjects, virome compositions were significantly associated with the oral sites from which they were derived. The largest distinctions between virome compositions were found when comparing the subgingival and supragingival biofilms to those of planktonic saliva. Differences in virome composition were significantly associated with oral health status for both subgingival and supragingival biofilm viruses but not for salivary viruses. Among the differences identified in virome compositions was a significant expansion of myoviruses in subgingival biofilm, suggesting that periodontal disease favors lytic phage. We also characterized the bacterial communities in each subject at each biogeographic site by using the V3 hypervariable segment of the 16S rRNA and did not identify distinctions between oral health and disease similar to those found in viral communities. The significantly altered ecology of viruses of oral biofilm in subjects with periodontal disease compared to that of relatively periodontally healthy ones suggests that viruses may serve as useful indicators of oral health status.IMPORTANCELittle is known about the role or the constituents of viruses as members of the human microbiome. We investigated the composition of human oral viral communities in a group of relatively periodontally healthy subjects or significant periodontitis to determine whether health status may be associated with differences in viruses. We found that most of the viruses present were predators of bacteria. The viruses inhabiting dental plaque were significantly different on the basis of oral health status, while those present in saliva were not. Dental plaque viruses in periodontitis were predicted to be significantly more likely to kill their bacterial hosts than those found in healthy mouths. Because oral diseases such as periodontitis have been shown to have altered bacterial communities, we believe that viruses and their role as drivers of ecosystem diversity are important contributors to the human oral microbiome in health and disease states.
Improving the quality of patient handover on a surgical ward
Authors: Bradley Alison 
Published: May 2014

AbstractThe European Working Time Directive means safe patient hand over is imperative. It is the responsibility of every doctor and an issue of patient safety and clinical governance [1]. The aims of this project were to improve the quality of patient handover between combined assessment unit (CAU) and surgical ward FY1 doctors.The Royal College of Surgeons England (RCSEng) guidelines on surgical patient handover [1] were used as the standard. Data was collected throughout November 2013. A handover tool was then introduced and attached to the front of patient notes when a patient was transferred from CAU to the surgical ward. The doctor handing over the patient and the ward doctor receiving the handover signed this document. Policy was also changed so that handover should take place once the patient had received senior review on the CAU and was deemed appropriate for transfer to the surgical ward. Data from the handover tool was collated and checked against the list of surgical admission for February 2014.The number of patients handed over improved from 15 % to 45%. The quality of patient handover also improved. 0 patient handovers in November 2013 included all of the information recommended by the RCSEng guidelines. 100% of the patient handovers in February 2014 contained all the recommended information.Introduction of a handover tool and formalisation of timing of patient handover helped to improve quality and number of patients being handed over. Further work needs to be done to improve safe handover of surgical patients, particularly out of hours.
Domestic violence in a UK abortion clinic: anonymous cross-sectional prevalence survey
Authors: Motta Silvia , Penn-Kekana Loveday , Bewley Susan 
Published: May 2014

ObjectiveTo measure the prevalence of domestic violence (DV) experienced by women seeking termination of pregnancy (TOP) in a UK abortion clinic.MethodsA cross-sectional anonymous questionnaire survey of all women aged over 16 years accessing a TOP clinic in inner London between 20 May 2012 and 2 July 2012. The main outcome measures were: distribution of questionnaires, response rate, lifetime prevalence of abuse, past-year prevalence of physical and sexual abuse, prevalence of physical abuse during current pregnancy, relationship of lifetime abuse to number of terminations, and receptivity to DV services.ResultsQuestionnaires were distributed to 46% (383/828) of women accessing the clinic. Response rate was 50% (190/383). Lifetime prevalence of abuse was 16%. Past-year prevalence of physical abuse was 11% and sexual abuse was 4%. Prevalence of physical abuse during the current pregnancy was 4%. Prevalence of lifetime abuse was lower in women having a first termination (12%) versus one (20%) or two or more previous terminations (24%), although this was not statistically significant (p=0.192). The majority (75%) of participants expressing an opinion on the possibility of having a support service for DV in the abortion clinic setting were positive, unrelated to their personal experience, but some concerns were raised about implementation.ConclusionsIn order to provide effective support for women, services require a needs assessment of their local population. Asking women presenting for abortion about DV, even anonymously, is challenging but feasible. Future work should be directed to women's unmet safety needs.
A taxonomic revision of Otomantis Bolivar, 1890 (Mantodea: Hymenopodidae, Acromantinae) with description of five new species
Authors: LOMBARDO FRANCESCO , STIEWE MARTIN B.D. , IPPOLITO SALVATRICE , MARLETTA ALESSANDRO 
Published: May 2014

The African genus Otomantis Bolivar, 1890, is taxonomically treated via the re-description of its species on the basis of new morphological features (pronotum and male genitalia). Five new species, O. centralis sp. n. from D. R. of Congo and Angola, O. gracilis sp. n. from D. R. of Congo, O. trimacula sp. n. from Zambia and Malawi, O. bolivari sp. n. from Kenya and Tanzania and O. minima sp. n. from South Africa are described. The taxonomic position of the syntypes of O. capirica Giglio-Tos is revised. A lectotype is designated for the female of O. capirica. The female of O. rendalli (Kirby) and the male of O. aurita (Saussure & Zehntner) are described for the first time. Also provided are many new localities for all nominal species. A key to the species of Otomantis is included for both male and female, each key fully illustrated. Finally, observations on species distributions and relationships are presented.
Improving Storm Surge Risk Communication: Stakeholder Perspectives
Authors: Morrow Betty H. , Lazo Jeffrey K. , Rhome Jamie , Feyen Jesse 
Published: May 2014

AbstractStorm surge associated with tropical and extratropical cyclones has a long history of causing death and destruction along our coastlines. With more than 123 million people living in coastal shoreline areas and much of the densely populated Atlantic and Gulf coastal areas less than 10 ft (∼3 m) above mean sea level, the threat has never been greater. In this article, we summarize and integrate the most intensive series of studies completed to date on communication of storm surge risk. These were primarily geographically focused stakeholder surveys for evaluating the storm surge communication perceptions and preferences of forecasters, broadcast meteorologists, public officials, and members of the public—each a primary user group for storm surge forecasts. According to findings from seven surveys, each group strongly supports the National Weather Service (NWS) issuing watches and warnings for storm surge, whether associated with tropical cyclones (TC) or extratropical (ET) cyclones. We discuss results on public understanding of storm surge vulnerability, respondents’ preferences for separate storm surge information products, and initial assessments of potential storm surge warning text and graphics. Findings from the research reported here are being used to support relevant NWS decisions, including a storm surge watch and warning product that has been approved for use on an experimental basis in 2015 and the National Hurricane Center (NHC) issuance of local surge inundations maps on an experimental basis in 2014.
Reemergence Mechanisms for North Pacific Sea Ice Revealed through Nonlinear Laplacian Spectral Analysis*
Authors: Bushuk Mitchell , Giannakis Dimitrios , Majda Andrew J. 
Published: May 2014

Abstract
This paper studies spatiotemporal modes of variability of sea ice concentration and sea surface temperature (SST) in the North Pacific sector in a comprehensive climate model and observations. These modes are obtained via nonlinear Laplacian spectral analysis (NLSA), a recently developed data analysis technique for high-dimensional nonlinear datasets. The existing NLSA algorithm is modified to allow for a scale-invariant coupled analysis of multiple variables in different physical units. The coupled NLSA modes are utilized to investigate North Pacific sea ice reemergence: a process in which sea ice anomalies originating in the melt season (spring) are positively correlated with anomalies in the growth season (fall) despite a loss of correlation in the intervening summer months. It is found that a low-dimensional family of NLSA modes is able to reproduce the lagged correlations observed in sea ice data from the North Pacific Ocean. This mode family exists in both model output and observations and is closely related to the North Pacific gyre oscillation (NPGO), a low-frequency pattern of North Pacific SST variability. Moreover, this mode family provides a mechanism for sea ice reemergence in which summer SST anomalies store the memory of spring sea ice anomalies, allowing for sea ice anomalies of the same sign to appear in the fall season. Lagged correlations in model output and observations are significantly strengthened by conditioning on the NPGO mode being active, in either positive or negative phase. Another family of NLSA modes, related to the Pacific decadal oscillation (PDO), is found to capture a winter-to-winter reemergence of SST anomalies.
Tolerability, Toxicity, and Temporal Implications of Transoral Robotic Surgery (TORS) on Adjuvant Radiation Therapy in Carcinoma of the Head and Neck
Authors: Carpenter Todd J. , Kann Benjamin , Buckstein Michael H. , Ko Eric C. , Bakst Richard L. , Misiukiewicz Krzysztof J. , Posner Marshall R. , Genden Eric M. , Gupta Vishal 
Published: May 2014

Objectives: Overall treatment package time (from surgery to radiotherapy [RT] completion) > 100 days can portend poor outcomes in head and neck cancer. Faster postoperative recovery seen with transoral robotic surgery may decrease treatment duration and toxicity for adjuvant RT and chemoradiation. Methods: We retrospectively reviewed all patients treated with transoral robotic surgery (n = 124) and adjuvant RT and chemoradiation (n = 33) at our institution for head and neck cancer from April 2007 to December 2011 to determine treatment duration, acute toxicity, and long-term percutaneous gastric tube rates. Results: The median overall treatment time was 86 days and from surgery to RT start was 41 days; median RT duration was 44 days. No wound breakdown or infection occurred during or after RT. Two-year actuarial locoregional control, distant metastasis–free survival, and overall survival rates were 93%, 96%, and 97%, respectively. Conclusions: Adjuvant RT after transoral robotic surgery for head and neck cancer can be completed safely and in a timely fashion. Longer follow-up and a larger cohort will be needed to determine if this regimen is more effective than traditional surgery followed by adjuvant RT.