bluuebunny/crossref_metadata_2025_split huggingface dataset:
Re‐Examining the Predictive Validity and Establishing Risk Levels for the Dynamic Appraisal of Situational Aggression: Youth Version
Authors: Maguire Tessa , Bowe Steven , Kasinathan John , Daffern Michael 
Published: August 2024

ABSTRACTThe Dynamic Appraisal of Situational Aggression: Youth Version (DASA:YV) is a brief instrument, most often used by nurses and was specifically designed to assess risk of imminent violence in youth settings. To date, it has been recommended that DASA:YV scores are interpreted in a linear manner, with high scores indicating a greater level of risk and therefore need more assertive and immediate intervention. This study re‐analyses an existing data set using contemporary robust data analytic procedures to examine the predictive validity of the DASA:YV, and to determine appropriate risk bands. Mixed effect logistic regression models were used to determine whether the DASA:YV predicted aggression when the observations are correlated. Two approaches were employed to identify and test novel DASA:YV risk bands, where (1) three risk bands as previously generated for the adult DASA were used as a starting point to consider recategorising the DASA:YV into three risk bands, and (2) using a decision tree analysis method known as Chi‐square automated interaction detection to produce risk bands. There was no statistically significant difference between a four and three category of risk band. AUC values were 0.85 for the four‐ and three‐category options. A three‐category approach is recommended for the DASA:YV. The new risk bands may assist nursing staff by providing more accurate categorisation of risk state. Identification of escalation in risk state may prompt early intervention, which may also prevent reliance on the use of restrictive practices when young people are at risk of acting aggressively.
Talking About Things Important to Me: Mental Health Consumers' Experiences of Consumer‐Rated Measures
Authors: Lawn S. , Jiggins D. , Dickson R. , Coombs T. 
Published: August 2024

ABSTRACTSince 2002, National Outcomes and Casemix Collection of clinician‐rated and consumer‐rated outcome measures has become part of routine care within Australian clinical mental health services, aiming to ensure that services understand, improve and are accountable for effectiveness of treatment and care provision. Consumer‐rated outcome measures, implemented well, support basic human rights of consumers to be asked, heard and included equally in their own care. However, their use has lagged due to clinician inertia, uncertainty about their value to clinical care, assumptions about consumers' capacity to complete the measures and organisational cultural issues that have hampered more holistic assessment, consumer inclusion and care collaboration. Much is known about negative, largely tokenistic use of such measures, poor uptake and dominance of clinical approaches to measurement that privilege clinical expertise; however, little is known about consumers' positive experiences of using consumer‐rated measures, Therefore, our aims were as follows: to seek the views and experiences of mental health consumers of using consumer‐rated measures in their encounters with clinicians; to understand better whether there were benefits (and if so what) of consumer‐rated measures being used in routine mental health practice; to understand how feedback on the use of consumer‐rated measures can inform training for mental health staff; and to promote their wider use within mental health services. In‐depth interviews conducted with 10 Australian mental health consumers used interview questions co‐designed with lived experience and clinical advocates. Descriptive thematic analyses produced four themes emphasising consumers' preferences for completing the measures, the importance of explaining their purpose, how the process validated their feelings and was an opportunity for self‐reflection, sense‐making, trust‐building, and transparency in the encounter and empowerment. This research offers recommendations about the value of effective implementation of consumer‐rated measures.
Dual‐mode optical thermometry based on glass‐ceramics from blast furnace slag
Authors: Xie Jing , Cao Qianwen , Zhong Yue , Su Tao , Shu Weijia , Wei Xiantao , Pan Yan , Long Hongming , Li Yong 
Published: August 2024

AbstractA series of glass ceramic samples precipitated with Ca2(Mg0.5Al0.5)(Si1.5Al0.5O7): Yb3+, Er3+ nanoparticles were synthesized by the melt quenching method to effectively recycle blast furnace slag. Their structures, morphologies, and luminescent properties were comprehensively investigated using X‐ray diffraction, transmission electron microscopy, and photoluminescence, respectively. The impact of adding Al2O3/SiO2 to the blast furnace slag raw material on the transmittance, hardness, and luminescent properties of the glass‐ceramics was analyzed. Upon excitation with a 980 nm laser, all glass‐ceramic samples emitted strong Er3+ upconversion luminescence at 526, 549, and 650 nm. Moreover, the addition of Yb3+ ions significantly enhanced the luminescent intensity. A dual‐mode temperature sensor based on fluorescence intensity ratios was realized using a single luminescent center. All results indicate that the glass ceramic samples prepared from blast furnace slag are potentially promising for self‐referential optical temperature measurement.
Unleashing frailty from laboratory into real world: A critical step toward frailty‐guided clinical care of older adults
Authors: Kim Dae Hyun 
Published: August 2024

AbstractUnderstanding patients' degree of frailty is crucial for tailoring clinical care for older adults based on their physiologic reserve and health needs (“frailty‐guided clinical care”). Two prerequisites for frailty‐guided clinical care are: (1) access to frailty information at the point of care and (2) evidence to inform decisions based on frailty information. Recent advancements include web‐based frailty assessment tools and their electronic health records integration for time‐efficient, standardized assessments in clinical practice. Additionally, database frailty scores from administrative claims and electronic health records data enable scalable assessments and evaluation of the effectiveness and safety of medical interventions across different frailty levels using real‐world data. Given limited evidence from clinical trials, real‐world database studies can complement trial results and help treatment decisions for individuals with frailty. This article, based on the Thomas and Catherine Yoshikawa Award lecture I gave at the American Geriatrics Society Annual Meeting in Long Beach, California, on May 5, 2023, outlines our group's contributions: (1) developing and integrating a frailty index calculator (Senior Health Calculator) into the electronic health records at an academic medical center; (2) developing a claims‐based frailty index for Medicare claims; (3) applying this index to evaluate the effect of medical interventions for patients with and without frailty; and (4) efforts to disseminate frailty assessment tools through the launch of the eFrailty website and the forthcoming addition of the claims‐based frailty index to the Centers for Medicare and Medicaid Services Chronic Conditions Data Warehouse. This article concludes with future directions for frailty‐guided clinical care.
Automated immunohistochemistry of intra‐epidermal nerve fibres in skin biopsies: A proof‐of‐concept study
Authors: Burgess Jamie , Marshall Anne , Rapteas Leandros , Hamill Kevin J. , Marshall Andrew , Malik Rayaz A. , Frank Bernhard , Alam Uazman 
Published: August 2024

AbstractAimsTo develop a standardised, automated protocol for detecting protein gene product 9.5 (PGP9.5) positive intra‐epidermal nerve fibres (IENFs) in skin biopsies, transitioning from the established manual technique to an automated platform. This automated method, although currently intended for research applications, may improve the accessibility of this diagnostic test for small fibre neuropathy in clinical settings.MethodsSkin biopsies (n = 274) from 100 participants (fibromyalgia syndrome n = 62; idiopathic small fibre neuropathy: n = 16; healthy volunteers: n = 22) were processed using an automated immunohistochemistry platform. IENF quantification was performed by blinded examiners, with reliability assessed via a two‐way mixed‐effects model to evaluate inter‐ and intra‐observer variability.ResultsThe automated staining system reproduced intra‐epidermal nerve fibre density (IENFD) counts consistent with free‐floating sections (mean ± standard deviation: free‐floating: 5.6 ± 3.4 fibres/mm; automated: 5.9 ± 3.2 fibres/mm). A median difference of 0.3 with a lower bound 95% Confidence Interval (CI) at −0.00005 established non‐inferiority against a margin of −0.4 (p = .08). Specifically, the inter‐class correlation coefficient (class denotes consistency in measured observations) was 99% (95% CI: 0.9–1), indicating excellent agreement between free‐floating and automated methods. The inter‐ and intra‐class coefficient between examiners were both 99% (95% CI: 0.9–0.1) for IENFD, demonstrating high reliability using sections stained using the automated method.InterpretationAutomated immunohistochemistry provides high‐throughput reliable and reproducible intra‐epidermal nerve fibre quantification. This method, although currently proof‐of‐concept, for research use only, may be more widely deployed in histopathology laboratories to increase the adoption of IENFD assessment for the diagnosis of peripheral neuropathies.
TWEAK increases angiogenesis to promote diabetic skin wound healing by regulating Fn14/EGFR signaling
Authors: Zhu Ying‐jie , Chen Hu‐lin , Huang Jing‐kai , Cai Xin‐jie , Zhan Bang‐le 
Published: August 2024

AbstractObjectiveTumor necrosis factor‐like weak inducer of apoptosis (TWEAK), a member of tumor necrosis factor superfamily, can bind to fibroblast growth factor‐inducible 14 (Fn14) receptor and stimulate angiogenesis. The interaction between epidermal growth factor receptor (EGFR) and endothelial growth factor (EGF) leads to EGFR signal transduction and promotes angiogenesis. The objective of this study was to explore whether TWEAK participated in the diabetic skin wound healing by regulating Fn14/EGFR signaling.MethodsHuman umbilical vein endothelial cells (HUVECs) were treated with 35 mmol/L d‐glucose and classified into the Control Group, High Glucose (HG) Group and HG + TWEAK Group. Then, the TWEAK expression and the proliferation, migration and tubule formation of HUVECs were detected, respectively. In vivo experiment, the diabetic model was established by injecting streptozotocin (STZ, 50 mg/kg) into male BALB/c mice. On the back of successfully modeled diabetic mice, a full‐thickness skin wound of 6 mm diameter was formed. Then, the mice were randomly assigned into three groups: Blank Group, Phosphate Buffer Saline (PBS) Group, and TWEAK Group. Subsequently, expression levels of TWEAK, Fn14, EGFR and vascular endothelial growth factor (VEGF)‐A were measured, and the CD31 expression in the wounded skin tissue of mice was checked by immunohistochemistry staining.ResultsThe expression level of TWEAK in HUVECs of HG Group decreased significantly, as well as the viability, migration, and tubule formation of cells. After over‐expression of TWEAK, the cell viability, migration, and tubule formation abilities of HUVECs recovered remarkably. In vivo, the wound healing rate of diabetic mice was raised, the neovascularization was increased, and the CD31 expression in the wounded tissue was obviously upregulated after injection with recombinant TWEAK antibody.ConclusionTWEAK stimulates angiogenesis and accelerates the wound healing of diabetic skin by regulating Fn14/EGFR signaling.
Krill oil supplementation improves transepidermal water loss, hydration and elasticity of the skin in healthy adults: Results from two randomized, double‐blind, placebo‐controlled, dose‐finding pilot studies
Authors: Handeland Katina , Wakeman Mike , Burri Lena 
Published: August 2024

AbstractBackgroundDietary marine omega‐3 fatty acids and phospholipids have individually shown favorable effects on skin barrier function. Krill oil offers a combination of omega‐3 in phospholipid form which might enhance the efficacy in supporting skin health.AimsThe aim was to investigate the impact of two different doses of krill oil on skin transepidermal water loss (TEWL) in healthy adults. Secondary outcomes were skin hydration, elasticity and the omega‐3 index.MethodsTwo randomized, double‐blind, placebo‐controlled, pilot studies were conducted in healthy adults with a baseline TEWL of >10 and ≤24.9 g/m2/h. In study 1, 51 participants consumed 1 g of krill oil or placebo daily. In study 2, 50 participants consumed 2 g of krill oil or placebo daily. The outcomes were assessed at baseline, 6 and 12 weeks.ResultsThe krill oil supplemented groups significantly increased their omega‐3 index versus placebo in both studies. Furthermore, the krill oil groups in both studies showed statistically significant beneficial reductions in TEWL (from 14.47 ± 3.65 to 13.83 ± 3.78 in study 1 and from 14.25 ± 3.21 to 13.02 ± 2.76 in study 2) and increases in hydration and elasticity when compared to placebo. There were significant linear relationships between changes in the omega‐3 index and changes in TEWL, hydration and elasticity in both studies.ConclusionsDaily oral supplementation with 1 and 2 g of krill oil showed significant and dose‐dependent improvements in skin TEWL, hydration, and elasticity compared to placebo that correlated with changes in the omega‐3 index.
A faster CO2 fractional scanner system mode for skin rejuvenation. A clinical study
Authors: Piccolo Domenico , Zingoni Tiziano , Fusco Irene , Madeddu Francesca , Conforti Claudio 
Published: August 2024

AbstractBackgroundThe market requires ever‐faster techniques, in particular for pre‐rejuvenation condition.AimThe purpose of this study was to assess if a fractional CO2 scanner modality (called moveo) results in a faster full‐face rejuvenation treatment in comparison to the standard mode, currently existing in the scanner system.Materials and MethodsA total of 12 female patients affected by fine lines participated in a split‐face clinical investigation and underwent to two sessions with a fractional CO2 laser system equipped with an existing and a faster dedicated scanner units. Pain was assessed using VAS. Three‐dimensional clinical photographs were captured before, immediately after, 3 days, 14 days after the first treatment and immediately after the second treatment and 1 months after the last one. The uniformity and aesthetic coverage of treatments were assessed using dermatoscopy. Global aesthetic improvement scale (GAIS) was used. The time taken to treat the two sides of the face and all possible side effects were monitored.ResultsFollowing only two treatment session with both scanner modes, the patient's skin texture improved significantly, with fine lines reduction. There is no statistically significant difference in perceived pain between patients. The GAIS score showed satisfactory results following both modalities. The time parameters indicated that with the faster scanner mode the full‐face treatment time was reduced by 30% compared to the standard one. No adverse effects were observed.ConclusionsThe moveo modality provide faster treatment and a better final dermal aesthetic outcome than the standard procedure while maintaining the same safety profile.
Helicobacter pylori infection in psoriatic patients and its relation to psoriasis severity: Cross Sectional Study
Authors: Abdel‐Hamid Soheir , Abdel‐Monem Shimaa Arafat 
Published: August 2024

AbstractBackgroundPsoriasis is a prevalent inflammatory skin condition that can be recognized by silvery‐white scales on plaques and erythematous papules, despite the fact that psoriasis appears to have multiple causes. Helicobacter pylori (H. pylori) has been investigated recently as a potential infectious etiological component.AimsThe objective of the study was to evaluate the prevalence of H. pylori infection in psoriatic patients compared to that of healthy controls and determine whether the degree of psoriasis and H. pylori infection were related.Patients and methodsThe dermatology, venerology, and andrology department at South Valley University Outpatient Clinic carried out this cross‐sectional study. Psoriatic patients of both sexes and ages were included. In addition to the control group, H. Pylori antigen was measured from psoriatic and control groups by using H. pylori stool antigen‐enzyme linked immunosorbent assay (HpSA‐ELISA), a test for H. pylori stool antigen. More than 20 ng/mL of antigen proved positive, or less than 15 ng/mL proved negative.ResultsThere was a significant difference between psoriatic patients and control regarding H. pylori infection (p = 0.046): (30.66%) positive in controls, (45.33%) positive in psoriatic patients. Both groups were matched for age (p = 0.908), that is, the mean age of psoriatic patients was 37.44 ± 15.79 years, and the control group was 37.15 ± 15.15 years. Twenty‐five psoriatic patients in each group: mild, moderate, and severe psoriasis according to the Psoriasis Area Severity Index (PASI) score. No significant correlation between H. pylori infection and PASI, age, or duration of illness in psoriatic patients.ConclusionsPatients with psoriasis had greater rates of H. pylori infection but didn't affect the severity of psoriasis.
LC‐OCT as a tool to visualize in vivo location of dermal fillers
Authors: Musolff Noah , Sanabria Bianca , Caetano Victoria , Pulgarin Laura , Chaudhry Zaima Sohail , Rao Babar 
Published: August 2024

AbstractBackgroundDermal fillers have emerged as a popular non‐surgical solution for facial rejuvenation and enhancement. Apart from botulinum toxin injections, they are the most common non‐surgical procedure performed in the US. Line‐field optical coherence tomography (LC‐OCT; deepLive system Damae Medical, France) represents one of the most recent developments in non‐invasive skin imaging technologies.Materials and methodsWe performed LC‐OCT image acquisition on six patients that were treated with hyaluronic acid (HA) dermal fillers in various locations on the face. The images were acquired before the application of the fillers (T0), immediately after (T1), and at a 6‐ to 8‐week (T2) follow‐up visit.ResultsAt T0, we were able to appreciate a normal‐appearing epidermis, dermoepithelial junction, and dermis. At T1, the intradermal filler deposits appeared as homogeneously hyporeflective areas, clearly discernible from surrounding vessels and other structures. At T2, the deposits were distinguishable as hyporeflective areas, although they were diminished in size compared to T1. On enface view, collagen fibers had increased thickness and were more homogeneously organized and hyperreflective.ConclusionsWe established the usefulness of LC‐OCT in the non‐invasive evaluation of dermal HA fillers to visualize both short‐term and medium‐term effects. LC‐OCT may be a valuable tool in evaluating the precise location of filler placement and follow‐up of resulting in vivo changes.
Collecting Duct Pro(Renin) Receptor Contributes to Unilateral Ureteral Obstruction–Induced Kidney Injury via Activation of the Intrarenal RAS
Authors: Luo Renfei , Yang Kevin T. , Wang Fei , Zheng Huaqing , Yang Tianxin 
Published: August 2024

BACKGROUND:
Although the concept of the intrarenal renin-angiotensin system (RAS) in renal disease is well-described in the literature, the precise pathogenic role and mechanism of this local system have not been directly assessed in the absence of confounding influence from the systemic RAS. The present study used novel mouse models of collecting duct (CD)–specific deletion of (pro)renin receptor (PRR) or renin together with pharmacological inhibition of soluble PRR production to unravel the precise contribution of the intrarenal RAS to renal injury induced by unilateral ureteral obstruction.

METHODS:
We examined the impact of CD-specific deletion of PRR, CD-specific deletion of renin, and S1P (site-1 protease) inhibitor PF429242 treatment on renal fibrosis and inflammation and the indices of the intrarenal RAS in a mouse model of unilateral ureteral obstruction.

RESULTS:
After 3 days of unilateral ureteral obstruction, the indices of the intrarenal RAS including the renal medullary renin content, activity and mRNA expression, and Ang (angiotensin) II content in obstructed kidneys of floxed mice were all increased. That effect was reversed with CD-specific deletion of PRR, CD-specific deletion of renin, and PF429242 treatment, accompanied by consistent improvement in renal fibrosis and inflammation. On the other hand, renal cortical renin levels were unaffected by unilateral ureteral obstruction, irrespective of the genotype. Similar results were obtained via pharmacological inhibition of S1P, the key protease for the generation of soluble PRR.

CONCLUSIONS:
Our results reveal that PRR-dependent/soluble PRR–dependent activation of CD renin represents a key determinant of the intrarenal RAS and, thus, obstruction-induced renal inflammation and fibrosis.
Predictive Ability of the Dynamic Appraisal of Situational Aggression-Inpatient Version (DASA-IV) in Medical-Surgical Units
Authors: Shirk Heather , Kreider Christy , Bell Theodore , Gervase Suzanne , Buchko Barbara L. , Danford Cynthia A. 
Published: August 2024

Background: Workplace violence persists in health care with nurses reporting physical and verbal abuse from aggressive patients causing emotional stress and lost workdays. The Dynamic Appraisal of Situational Aggression–Inpatient Version (DASA-IV) was developed to measure risk for aggression in patients with behavioral health conditions in psychiatric and emergency department settings. The DASA-IV has not been validated with adult patients admitted to medical-surgical units. Objective: To determine whether DASA-IV scores are predictive of aggressive events in adults hospitalized on medical-surgical units. Methods: This multisite study used a case-control design. DASA-IV scores and acts of aggression were extracted from the medical record retrospectively to validate the appraisal’s predictability. Receiver operating characteristic (ROC) and area under the curve (AUC) were used to correlate DASA-IV scores with aggressive events. Results: DASA-IV assessments (N=156 999; mean [SD] 10.1 [10.7]/patient; range 1-220) were collected from 13 611 patients. Patients were primarily White (86.1%) and female (51.7%). Aggression (n = 509 patients; 3.7%) was significantly associated with older age, male sex, smoking, illicit drug use, and high DASA-IV scores. AUC of the ROC analysis for the DASA-IV showed a 97% probability (95% confidence interval [CI] 0.964-0.977) that an aggressive patient would have a higher score on the DASA-IV than a nonaggressive patient. Binary logistic regression predicted that for every point increase in the DASA-IV, there was a 3.51 (95% CI 3.38-3.63) times increased risk for aggression ( B  = 1.255, SE = 0.18, Wald = 4766.6, P < .001). Conclusions: This study is the first to validate use of the DASA-IV in medical-surgical populations, demonstrating predictive ability for aggressive incidents. The DASA-IV can be used successfully in medical-surgical populations for early identification of potential aggression.