bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soft power in complicated and complex education systems: Gender, education and global governance in organisational responses to SDG 4
Authors: Unterhalter Elaine 
Published: August 2024

AbstractThis article examines how the distinction between complicated and complex education systems contributes to our understanding of global governance and how “soft power” concerned with gender is used in international development organisations’ responses to Sustainable Development Goal (SDG) 4, the global goal for education. Four global governance approaches which shape these organisations are distinguished: partnership building, gender mainstreaming, gender activism and contestation by global feminist movements. These strands of soft power have implications for how meanings of gender, education, power and accountability are interpreted. The work of three organisations – the Global Partnership for Education (GPE), the Gender at the Centre Initiative (GCI) and the Malala Fund – are reviewed to exemplify these global governance approaches. The analysis draws on a close reading of the organisations’ published documents to build a history of how the gender concerns of SDG 4 came to be interpreted, negotiated, contested or ignored. The activities of the three organisations show considerable interplay between concepts of complicated and complex education systems. The discussion raises questions regarding what kind of work soft power in gender and education does in a context of huge and growing global inequalities and insecurities. In addition, the question is posed why there is still no institutional base to articulate a global feminist politics which confronts and seeks to dismantle unjust structures of power.
Analysis of microplastics in the reuse of compost in three agricultural sites (Cádiz, Spain) as a circular economy strategy: detection of micropollutants and incidence of plastic ingestion levels by annelids
Authors: Sakali Ayda , Egea-Corbacho Agata , Coello Dolores , Albendín Gemma , Arellano Juana , Rodríguez-Barroso Rocío 
Published: August 2024

AbstractThe system of fertilizing agricultural soils with sludge or compost from wastewater treatment processes, as one of the principles of the circular economy, can lead to microplastic (MP) contamination. The existing technical standards for fertilization are very recent and do not consider this problem, although there is scientific evidence of their existence. Therefore, this study, on the one hand, evaluates the presence of MPs in agricultural soils, previously treated with sludge or compost from wastewater treatment plants for fertilization, and on the second hand, it studies the effect of these MPs on earthworms in three different locations in the south of Spain. For the study, selected composts deriving from the different stages of the composting process and three fertilized soils with increasing MP doses were followed. Samples were taken from different sections in depth (0–5, 5–10, and 10–20 cm) to study the shape, size, type, and abundance of MPs using infrared spectroscopy (FTIR). The results showed that the most abundant shape was fiber, followed by fragment and finally bulk, for both composts and soils. Regarding size distribution, 100 µm was the predominant size in composts (64.3% ± 9.8), while in the case of soils, the predominant range was from 100 to 500 µm. The prevalent polymers in both, composts and soils, were PTFE, TPE, PP, and PET, with four times higher amounts in composts than in soils. Ingestion of common MPs were also verified in two earthworm species, which ingested concentrations higher than 2.1% w/w. PP was the most ingested MP and Eisenia fetida was more voracious compared with Lumbricus terrestris. Therefore, it can be considered a suitable bioindicator for monitoring microplastic contamination in agricultural soil.
Graphical Abstract
Comparative study of polyphenol extraction using physical techniques and water as a solvent: a sustainable approach for the valorization of apple pomace
Authors: Fraterrigo Garofalo Silvia , Demichelis Francesca , Peletti Veronica , Picco Lorenzo , Tommasi Tonia , Fino Debora 
Published: August 2024

AbstractApples are among the most commonly cultivated fruits globally. Approximately 65% of annual apple production is transformed into apple juice concentrate generating a large amount of waste material named apple pomace, which includes seeds, skin, and other components. Disposing of apple by-products directly into the environment constitutes a source of environmental pollution due to its high-water content and easily fermentable nature. Apple pomace is rich in polyphenols that can be utilized as active components in cosmetic, nutraceutical, or pharmaceutical products. The present study aims to describe and compare different physical methods for the extraction of polyphenols from apple pomace. Water was used as the extraction solvent in thermal-stirred extraction (TSE), ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE). The best extraction conditions were identified in terms of solid to solvent ratio, temperature, power, and time through a kinetic study. The best extraction parameters were compared environmentally on a pilot scale through a life cycle assessment (LCA). All the results demonstrated the MAE is the best technique to extract polyphenol from apple pomace in terms yield and environmental impact proving that it is possible to transform waste into a sustainable source of bioactive ingredients.
Educational heterogeneity of the founding team of innovative start-ups: confirmations and denials
Authors: Fiorentino Raffaele , Longobardi Sergio , Morrone Carla , Scaletti Alessandro 
Published: August 2024

AbstractThis paper focuses on the value drivers of innovative start-ups (ISUs). Few companies can overcome the start-up stage; often, the early performance is insufficient, and the potential contribution of innovation to economic development is very poor. Studies based on a firm-level perspective show mixed results on the factors affecting the growth of ISUs. Most studies emphasize the role of “external” drivers of ISUs growth, while more knowledge is required of “internal” drivers. Consequently, this research focuses on the relationship between the features of the founding teams and the early performance of ISUs. Specifically, it concentrates on education heterogeneity and analyzes whether the heterogeneity of the founding team in terms of educational level (vertical heterogeneity) and field of studies (horizontal heterogeneity) affects the Italian ISUs performance. Growth regression and unconditional quantile regression models confirm the prior literature: the educational level affects the performance and the vertical heterogeneity in the composition of the founding team is relevant for ISUs performance. However, the results also suggest interesting denials: horizontal heterogeneity does not play any role, and no moderating effect of heterogeneity is shown. These findings are strongly attractive for new ventures and policymakers.
Effect of stress conditions on concentrated leak erosion resistant of fine-grained soils with different characteristics
Authors: Topçu Sadettin , Savaş Hasan , Tosun Hasan 
Published: August 2024

AbstractInternal erosion is one of the most important factors that cause earth structures that retain water, such as embankment dams, to collapse. Concentrated leak erosion, one of the forms of internal erosion, occurs in cracked fine-grained soils and pressurized flow conditions. To evaluate the concentrated leak erosion risk of cracks/voids, it is necessary to ascertain the erosion resistance of these materials. The erosion rate and critical shear stresses determine internal erosion resistance in concentrated leak erosion. This study determined soil’s concentrated leak erosion resistance using test equipment that allowed the flow to pass through a hole with stress-free (no loading), anisotropic-compression stress, anisotropic-expansion stress, and isotropic stress conditions. The stresses that developed in the samples’ hole wall where erosion occurred were determined with numerical modeling as pre-experimental stress conditions. The experiments were performed under a single hydraulic head on four selected cohesive soils with different erosion sensitivity. Time-dependent flow rates obtained from the test system can be used to determine hydraulic parameters, such as energy grade lines, with the help of basic theorems of pipe hydraulics in theoretical hydraulic models. Moreover, the erosion rates were quantitatively determined using the continuity equation, while critical shear stresses were qualitatively compared for concentrated leak erosion developed by the dispersion mechanism. As a result of the experiments, stress conditions influence the concentrated leak erosion resistance in the soil samples with dispersive erosion. Moreover, the shear strength in the Mohr–Coulomb hypothesis can explain the erosion resistance in these soils under stress conditions depending on the sand/clay ratio.
Development of a human machine interface for robotically assisted surgery optimized for laparoscopic workflows
Authors: Wegener Luca , Wilhelm Dirk , Berlet Maximilian , Fuchtmann Jonas 
Published: August 2024

Abstract

Introduction

In robotic-assisted surgery (RAS), the input device is the primary site for the flow of information between the user and the robot. Most RAS systems remove the surgeon’s console from the sterile surgical site. Beneficial for performing lengthy procedures with complex systems, this ultimately lacks the flexibility that comes with the surgeon being able to remain at the sterile site.

Methods

A prototype of an input device for RAS is constructed. The focus lies on intuitive control for surgeons and a seamless integration into the surgical workflow within the sterile environment. The kinematic design is translated from the kinematics of laparoscopic surgery. The input device uses three degrees of freedom from a flexible instrument as input. The prototype’s performance is compared to that of a commercially available device in an evaluation. Metrics are used to evaluate the surgeons’ performance with the respective input device in a virtual environment implemented for the evaluation.

Results

The evaluation of the two input devices shows statistically significant differences in the performance metrics. With the proposed prototype, the surgeons perform the tasks faster, more precisely, and with fewer errors.

Conclusion

The prototype is an efficient and intuitive input device for surgeons with laparoscopic experience. The placement in the sterile working area allows for seamless integration into the surgical workflow and can potentially enable new robotic approaches.
Exploring Microstructure and Magnetic Domain Evolution in the As-cast Soft Magnetic Fe74B20Nb2Hf2Si2 Alloy: A Comprehensive Study Using STEM, Lorentz TEM, and LM-STEM DPC Microscopy
Authors: Czaja Pawel , Rezaei-Shahreza Parisa , Hasani Saeed , Seifoddini Amir , ´Sliwa Agata , Nabiałek Marcin 
Published: August 2024

AbstractThis study delves into subtle changes in the microstructure and domain arrangement of a Fe74B20Nb2Hf2Si2 soft magnetic amorphous alloy. Utilizing transmission electron microscopy in Lorentz mode, low-magnification STEM, and differential phase contrast analysis (DPC), the research explores both the as-cast state and annealed samples. The results confirmed the formation of α-Fe, Fe23B6, Fe2(Hf, Nb), and Fe2B crystalline phases with increasing annealing temperature. Consequently, these crystallization stages induce significant alterations in magnetic domain size and spatial distribution due to microstructural changes. As the crystallization temperature rises, the volume fraction of crystalline phases increases, leading to modifications in the arrangement and size of magnetic domains. The decrease in magnetic domain size, associated with the formation of pinning sites during heat treatment, leads to alterations in soft magnetic properties. This includes an increase in coercivity (Hc) up to 40 A/m in the sample annealed at the temperature range of the third crystallization stage compared to the as-cast sample (1.5 A/m). Furthermore, as the annealing temperature rises, there is a corresponding increase in saturation magnetization (Ms), which reached to 1.71 T in the sample annealed within the temperature range of the third crystallization stage. These findings hold substantial implications for the practical applications of the Fe-based soft bulk metallic glasses (BMGs) alloy across various industries.
A simple and effective method coupling coagulation and UV/TiO2 photocatalysis for treating real-produced wastewater from oil processing
Authors: Rosa Domenico , Hasanova Seynura , Abbasova Nigar , Nacer Hamza , Aliyev Fegan , Di Palma Luca 
Published: August 2024

AbstractThe complex composition of real-produced wastewater from oil processing poses significant challenges for wastewater treatment. The employed conventional methods have disadvantages such as low efficiency, high-cost demand, secondary waste, adverse effects on the environment and need to be intensified. The combined treatment of coagulation (carried out with Al2(SO4)3) and photocatalysis (UV/TiO2) was studied on wastewater produced from a SOCAR (Pirallahi dry well) oil extraction plant and synthetic paracetamol-based wastewater. Two different dosages of Degussa P25 catalyst at different pH conditions and ion presence were studied. Characterization of the produced wastewater showed the complexity of the treated matrix given the presence of inorganic ions and aromatic and aliphatic contaminants, and an important parameter that was reduced through coagulation was turbidity. The initial concentration expressed as THC was 714 mg/L. At the end of the treatment, a THC value of 210 mg/L was reached.
The Composition of Graded Dental Zirconias
Authors: Maharishi Anvita , Horkley Kenny , Unruh Daniel K. , McLaren Edward A. , White Shane N. 
Published: August 2024

AbstractZirconia dental ceramics have evolved from uniform blocks of 3 mol.% yttria (3Y) to strength- and color-graded blocks containing 3 mol.% and 5 mol.% components. Relatively little is known about the graded materials’ compositions and microstructures. Concerns have been raised about aging and degradation. This study investigated the microstructure, elemental composition, and phase content of different zones of strength- and color-graded zirconia blocks using scanning electron microscopy, x-ray fluorescence, and x-ray diffraction. Specimens were made from green-state blocks using CAD/CAM machining and sintering. Two strength- and color-graded zirconia materials had different grain sizes, elemental compositions, and phase contents between their top and bottom zones, these data being internally consistent as well as being broadly consistent with prior compositional physical property data. A color-graded zirconia material did not exhibit substantial differences between its top and bottom zones, consistent with expectations and previously published data. Modeling phase content for complex yttria-doped zirconia crystal systems with multiple heterogeneous crystal lattices from XRD data was inherently difficult, which may account for the ranges among previously published data; authors should describe detailed methodologies. Detailed compositional data at the scale of the microstructure is needed to relate composition to phase content, physical behavior, including crack evolution.
Native nephrectomies in patients with autosomal dominant polycystic kidney disease: retrospective cohort study
Authors: Hogan Richard Edmund , McHale Barry , Dowling Gavin Paul , Elhassan Elhussein , Kilkenny Conor James , Mohan Ponnusamy , Conlon Peter 
Published: August 2024

Abstract
Background
Approximately 1 in 5 patients with autosomal dominant polycystic kidney disease (ADPKD) will undergo a native nephrectomy in their lifetime. These can be emergent or planned and the indications can range from space for kidney transplant, pain, hematuria and frequent urinary tract infections (UTIs). Due to the diverse nature of presentations, there is a lack of certainty about outcomes and optimal management.

Aims
This study aimed to evaluate preoperative indications and perioperative/postoperative complications in this patient cohort.

Methods
This retrospective review included 41 patients with ADPKD who underwent unilateral or bilateral nephrectomy in a single hospital between 2010 and 2020. We collected data on patient demographics, surgical indications, histological results and postoperative complications. We sourced this information using the hospital’s patient medical records.

Results
The main indications for nephrectomy were pain (39.5%) and bleeding (41.8%). Further indications included recurrent UTIs (16.3%), space for transplantation (27.9%), query malignancy (4.7%) and compressive gastropathy (2.3%). With regard to side, 55.8% were right-sided, 23.3% were left-sided, and 20.9% were bilateral. Seven percent of nephrectomy specimens demonstrated malignancy. Postoperative morbidity included requiring blood transfusion and long hospital stay. Thirty-seven percent of patients received a postoperative blood transfusion. There was no immediate or postoperative mortality associated with any of the cases reviewed.

Conclusions
In conclusion, this study demonstrates that native nephrectomy remains a safe operation for patients with ADPKD. Although further research is needed into, transfusion protocols, adjunctive therapies, such as TAE and research into timing of nephrectomy are still needed.
A Methodological Benchmark in Determining the Urban Growth: Spatiotemporal Projections for Eskişehir, Türkiye
Authors: Isinkaralar Oznur 
Published: August 2024

AbstractUrban growth changes spatial uses over time due to different dynamics. These processes cause many physical, environmental, and socioeconomic problems, such as climate change, pollution, and population-related events. Therefore, it is essential to predict future urban expansion to produce effective policies in sustainable urban planning and make long-term plans. Many models, such as dynamic, statistical, and Cellular Automata and Markov Chain (CA-MC) models, are used in geographic information system (GIS) environments to meet the high-performance requirements of land use modeling. This study estimated the growth of settled areas in Eskişehir city center using models developed using two different methods. In this context, settled areas in the city center were examined within the scope of 1990–2018, and the growth areas of settled areas in 2046 were predicted using the CA-Markov method in Model 1: Quantum GIS (QGIS) MOLUSCE plugin and Model 2: IDRISI Selva. While settled areas are continuously increasing, other urban areas are decreasing. Model 1 predicts an increase of 1195 ha in settled areas by 2046, while Model 2 predicts an increase of 45,022 ha. At the same time, it is concluded that settled areas will grow in a central location in Model 1, while they will spread in an east-west extension in Model 2. The study results show that QGIS-based modeling predicts more limited spatial growth than IDRISI Selva. The research interprets growth in terms of the staging of urban services, the population size of neighboring cities, distances, and income levels based on the internal and external dynamics of the city.
Tumor-exosomal miR-205-5p as a diagnostic biomarker for colorectal cancer
Authors: Zhao Yajing , Zhao Yapeng , Liu Lisheng , Li Guanghao , Wu Yawen , Cui Yanan , Xie Li 
Published: August 2024

Abstract
Background
Tumor-derived exosomal miRNAs play crucial roles in cancer diagnosis. Current studies aim to identify exosomal miRNAs associated with colorectal cancer (CRC) that are noninvasive, sensitive, and specific.

Patients and methods
Exosomes were extracted from CRC patients and healthy donors via ultracentrifugation, followed by verification via transmission electron microscopy (TEM), qNano, and Western blot analysis. The differential expression levels and clinical characteristics of miR-205-5p were analyzed in CRC via data from The Cancer Genome Atlas (TCGA). Real-time quantitative PCR was used to assess the expression levels of exosomal miRNAs in 157 primary CRC patients, 20 patients with benign diseases, and 135 healthy donors. Predictions regarding target genes were made to guide further exploration of the disease’s etiopathogenesis through bioinformatics.

Results
Compared with that in healthy donors, the expression of miR-205-5p in colorectal cancer (CRC) patients was significantly lower, as determined through analysis of the TCGA database. We conducted a prediction and analysis of the functional enrichment of downstream target genes regulated by miR-205-5p. A lower level of exosomal miR-205-5p in the serum of CRC patients than in that of healthy controls (p < 0.0001) and patients with benign disease (p < 0.0001) was observed. Furthermore, the expression levels of exosomal miR-205-5p were significantly lower in early-stage CRC patients than in the comparison groups (p<0.001 and p < 0.0001). Notably, the expression levels of exosomal miR-205-5p significantly increased postoperatively (p = 0.0053).

Conclusions
The present study demonstrated that serum exosomal miR-205-5p may be a diagnostic biomarker for CRC.
Importance of allogeneic stem cell transplantation in myelofibrosis
Authors: Hirschbühl Klaus , Schmid Christoph 
Published: August 2024

SummaryAllogeneic stem cell transplantation (alloSCT) is the only curative treatment option for patients with high-risk myelofibrosis (MF). However, it is important to bear in mind that alloSCT in MF is associated with a nonrelapse mortality that should not be underestimated. Therefore, both exact disease risk categorization and thorough evaluation of the individual transplant-related risk are mandatory to identify those patients to whom alloSCT should be offered. This short review is intended to provide a concise overview on relevant aspects to be considered for patient selection, planning, and performing alloSCT.
Trastuzumab deruxtecan for the treatment of patients with HER2-positive breast cancer with brain and/or leptomeningeal metastases: an updated overall survival analysis using data from a multicenter retrospective study (ROSET-BM)
Authors: Nakayama Takahiro , Niikura Naoki , Yamanaka Takashi , Yamamoto Mitsugu , Matsuura Kazuo , Inoue Kenichi , Takahara Sachiko , Nomura Hironori , Kita Shosuke , Yamaguchi Miki , Aruga Tomoyuki , Shibata Nobuhiro , Shimomura Akihiko , Ozaki Yuri , Sakai Shuji , Takiguchi Daisuke , Takata Takehiko , Bastanfard Armin , Shiosakai Kazuhito , Tsurutani Junji 
Published: August 2024

AbstractWe provide updated results (median follow-up duration: 20.4 months) of a retrospective study on the effectiveness of trastuzumab deruxtecan (T-DXd) in patients with human epidermal growth factor receptor 2-positive (HER2+) breast cancer with brain metastases (BM) and/or leptomeningeal disease (ROSET-BM). Median progression-free survival (PFS) was 14.6 months. Median overall survival (OS) was not reached (NR); 24-month OS rate was 56.0%. Subgroup analysis showed that median PFS was 13.2 months in patients with analytical active BM, 17.5 months in patients with leptomeningeal carcinomatosis (LMC), and NR in patients with analytical stable BM (24-month PFS rates in patients with analytical active BM, LMC, and analytical stable BM were 32.7%, 25.1%, and 60.8%, respectively). Median OS was 27.0 months in patients with analytical active BM and NR in patients with LMC or analytical stable BM (24-month OS rates in patients with analytical active BM, LMC, and analytical stable BM were 52.0%, 61.6%, and 71.6%, respectively). The most common adverse event leading to discontinuation of T-DXd was interstitial lung disease (ILD; 23.1%); median ILD onset time among patients who discontinued T-DXd treatment due to ILD was 5.3 months. T-DXd has promising effectiveness in heavily pre-treated HER2+ metastatic breast cancer patients with BM and LMC. The incidence and median onset time of ILD were similar to those of Japanese subgroups in previous studies.