bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network-based Multi-omics Disease–Drug Associations Reveal Drug Repurposing Candidates for Covid-19 Disease Phases
Authors: Agamah Francis E. , Ederveen Thomas H. A. , Skelton Michelle , Martin Darren P. , Chimusa Emile R. , ‘t Hoen Peter A. C. 
Published: July 2024

Background
The development and rollout of vaccines and the use of various drugs have contributed to controlling the coronavirus disease 2019 (Covid-19) pandemic. Nevertheless, challenges such as the inequitable distribution of vaccines, the influence of emerging viral lineages and immunoevasive variants on vaccine efficacy, and the inadequate immune defense in subgroups of the population continue to motivate the development of new drugs to combat the disease.

Aim
In this study, we sought to identify, prioritize, and characterize drug repurposing candidates appropriate for treating mild, moderate, or severe Covid-19 using a network-based integrative approach that systematically integrates drug-related data and multi-omics datasets.

Methods
We leveraged drug data and multi-omics data and used a random walk with restart algorithm to explore an integrated knowledge graph comprising three subgraphs: (i) a Covid-19 knowledge graph, (ii) a drug repurposing knowledge graph, and (iii) a Covid-19 disease state-specific omics graph.

Results
We prioritized 20 US Food and Drug Administration-approved agents as potential candidate drugs for mild, moderate, and severe Covid-19 disease phases. Specifically, drugs that could stimulate immune cell recruitment and activation including histamine, curcumin, and paclitaxel have potential utility in mild disease states to mitigate disease progression. Drugs like omacetaxine, crizotinib, and vorinostat that exhibit antiviral properties and have the potential to inhibit viral replication can be considered for mild to moderate Covid-19 disease states. Also, given the association between antioxidant deficiency and high inflammatory factors that trigger cytokine storms, antioxidants like glutathione can be considered for moderate disease states. Drugs that exhibit potent anti-inflammatory effects like (i) anti-inflammatory drugs (sarilumab and tocilizumab), (ii) corticosteroids (dexamethasone and hydrocortisone), and (iii) immunosuppressives (sirolimus and cyclosporine) are potential candidates for moderate to severe disease states that trigger a hyperinflammatory cascade of Covid-19.

Conclusion
Our study demonstrates that the multi-omics data-driven integrative analysis within the drug data enables prioritizing drug candidates for Covid-19 disease phases, offering a comprehensive basis for therapeutic strategies that can be brought to market quickly given their established safety profiles. Importantly, the multi-omics data-driven integrative analysis within the drug data approach implemented here can be used to prioritize drug repurposing candidates appropriate for other diseases.
Pengembangan Soal Matematika Mode PISA Konten Statistika Untuk Melatih Kemampuan Literasi Statistik Siswa di SMP
Authors: Taneo Yosti Andiyani , Ralmugiz Uke , Fatmawati Agustin 
Published: July 2024

The purpose of this study was to determine the development and results of the development of mathematical problems of the Pisa model of statistical content to train students' statistical literacy at SMP Negeri 5 Kupang. The research method used is the research and development method. This research uses a four-D development model, namely define, design, develop, and disseminate. Validation of the PISA question trial resulted in 5 questions tested being declared valid. Reliability is generally stated to be reliable, with a test probability score of 0.62 with high interpretation, the distinguishing power produces 3 questions with sufficient criteria (1, 2 and 5), 1 question with good criteria (4) and 1 question with bad criteria (5) while the difficulty level of the questions produces 1 question with easy criteria (1), 3 questions with medium criteria (2, 3 and 4) and 1 question with difficult criteria. Overall it has been declared good. The difficulty level of PISA model math problems can be seen from the difficulty index of each question item. In accordance with the quality criteria of the test questions, it is known that the 5 questions are worthy of being tested on the field test. The results of the Field Test trial were obtained from 30 students, there were 24 students who had statistical literacy skills with very good categories, 5 students had statistical literacy skills with good categories, and 1 student had statistical literacy skills with sufficient categories so that they had an average of 84,666 with very good categories.
Analisis Kemampuan Spasial Matematis Siswa Dalam Menyelesaikan Masalah Geometri Bangun Ruang
Authors: Yulia Putri , Amanda Putri Fenti 
Published: July 2024

Abstract
Mathematics is often considered a difficult and intimidating subject by most students. This causes many students to struggle with solving mathematical problems, especially in the field of spatial geometry. Therefore, analyzing the mathematical spatial ability of students in solving spatial geometry problems is important. The aim of this study is to analyze the mathematical spatial ability of students at MAN3 Kerinci school. This study is a descriptive quantitative research. The subjects of this study are 10 students from class X at MAN3 Kerinci. Data collection techniques include tests, interviews, and documentation, and the data is analyzed using qualitative data analysis techniques. Based on the data analysis, it can be concluded that the level of spatial ability of the students is very low compared to the total number of students in the class.
Keywords: Spatial ability, Mathematics, Analysis, Observation

Abstrak
Matematika sering dianggap sebagai pelajaran yang sulit dan menakutkan oleh sebagian besar siswa.Hal ini menyebabkan banyak siswa kesulitan dalam menyelesaikan masalah matematika, terutama dalam masalah geometri bangun ruang. Oleh karena itu, analisis kemampuan spasial matematis siswa dalam menyelesaikan masalah geometri bangun ruang menjadi hal yang penting untuk dilakukan.Tujuan: Penelitian ini bertujuan untuk menganalisis kemampuan spasial matematis siswa sekolah MAN 3 Kerinci. Metode dalam penelitian ini merupakan penelitian deskriptif kuantitatif. Pengumpulan Data: Subjek penelitian ini adalah siswa kelas X MAN3 Kerinci yang terdiri dari 10 orang siswa.Dengan teknik pengumpulan data menggunakan tes, wawancara dan dokumentasi kemudian data dianalisis menggunakan teknik analisis data kualitatif. Analisis Data: Data dianalisis secara deskriptif. Hasil/Kesimpulan: Berdasarkan analisis data diperoleh kesimpulan bahwa tingkat kemampuan Spasial peserta didik tergolong Sangat Rendah dari jumlah keseluruhan siswa kelas.
Kata Kunci: kemampuan spasial, matematika, analisis, observasi.
КРИЗИС ДВОРЯНСКОЙ СЕМЬИ В 70-Е ГОДЫ XIX ВЕКА В РОМАНЕ Ф.М. ДОСТОЕВСКОГО «ПОДРОСТОК»
Authors: Крылова Л.А. , Кадыров Жанбай , Синбаева Г.К. 
Published: July 2024

Фёдор Достоевский в 1875 году представил вниманию общественности свой новый роман «Подросток», который критика, писатели-современники и читатели не поняли и не приняли, поставив на произведении штамп авторской неудачи. Весь XX век этот роман никогда не изучался в вузовских аудиториях, не было его и в школьных программах. Первым, кто назвал этот роман, как «одно из самых гениальных и недостаточно еще оцененных творений Достоевского» был русский философ Н.А. Бердяев.
Вечная проблема «отцов и детей» в романе «Подросток», исследуемая Ф.М. Достоевским в новом ракурсе, чем у других русских писателей-классиков. Писатель сместил акцент в своём произведении на «дети и отцы». Проблема воспитания подрастающего поколения всегда волновала Достоевского-мыслителя. В данном романе нет ни одной нравственно здоровой дворянской семьи, все находятся в состоянии распада или раздора. Достоевский отмечал, что прошли времена дворянского семейного лада, каким его изображал Лев Толстой в своих романах. В пореформенной России 70-х годов XIX века происходит разрушение основы архетипа дворянской семьи. Новое время породило семью-мезальянс и её детей-изгоев.
Тема отцов представлена в романе чёткой оппозицией в сословном и аксиологическом плане: кровный отец-дворянин-скиталец по Европе, духовный отец–странник-праведник по России. У автора слово «подросток» указывает не столько на возрастной ценз главного героя, сколько на ценностный этап на пути познания им истины. Взросление, самооценка и самосуд главного героя автор раскрывает через его записки. Исповедь главного героя – это этапы его исканий, поиски ответов на ценностно-смысловые и онтологические вопросы: кто он в этом мире: «князь», «будущий миллионер», «игрок», «шантажист», «грешник»? Нигилистическая идея сына – стать русским Ротшильдом порождает в герое двойника и душу паука. Главный герой проходит нравственные и духовные мытарства, чтобы обрести кровного и духовного отца и выйти из состояния сиротства. Дан анализ русскому двойничеству философом Н.А. Бердяевым и писателем-критиком Д.С. Мережковским контексте данного романа. В предсмертном письме Достоевский признавался в своём личном раздвоении и стремился распознать этот недуг у себя и у своих героев.
ЖОЛДАУ МӘТІНДЕРІНДЕГІ «МЕН» ЕСІМДІГІНІҢ ФУНКЦИОНАЛДЫ-ПРАГМАТИКАЛЫҚ ҚЫЗМЕТІ
Authors: Слямбек Қымбат 
Published: July 2024

Мақалада саяси лидер тіліндегі «мен» жіктеу есімдігінің прагматикалық күші жайында ғылыми тұжырымдар беріледі. Қазақстан президенттерінің жолдауындағы «мен» есімдігінің коммуникативті мақсатының түрлері сипатталып, қай президенттің қолданысында қандай коммуникативті интенцияның басым екені анықталады. Мақаланың ұсынған гипотезасы – ҚР-ның экс-президенті Н.Назарбаев пен қазіргі президенті Қ.Тоқаев жолдауларындағы «Мен» тұлғалық көрсеткішінің бағалауыштық және прагматикалық аспектілерінде айырмашылық барын, ондай айырмашылық президенттердің жеке тұлғалық дискурсымен байланысты екенін анықтау.
Жолдау мәтіндеріндегі «мен» категориясының қолданысын талдау саяси тұлғаның репрезентациялық болмысын сипаттауға мүмкіндік тудырады. Сөйлеуші демонстрациялық «мен» есімдігін қолдану арқылы мінез-құлқынан, психологиялық-ментальды жай-күйінен, прагматикалық интенциясынан хабар береді. Мақаланың мақсаты – осындай жеке дискурс сипатына ие тұлғалық қасиеттердің жолдау мәтіндеріндегі көрінісін анықтау. Зерттеуде ой-тұжырымды бекіту мақсатында қолданылу жиілігін есептеу принципі қолданылып, сандық көрсеткіштерге арқа сүйедік.
Hubungan Tingkat Pengetahuan Keselamatan Kerja dan Pelatihan Basic Safety Awareness terhadap Safety Behaviour dengan Menggunakan Perkasa Learn
Authors: Taufik Ramdan Rayhan , Hamdan Alifal 
Published: July 2024

Penerapan keselamatan kerja pada sektor pertambangan merupakan sesuatu yang penting, karena sektor pertambangan memiliki risiko yang besar terhadap kecelakaan kerja atau kecelakaan tambang. Atas dasar tersebut PT Putra Perkasa Abadi jobsite PT Bukit Asam Tbk menaruh perhatian serius terhadap penerapan keselamatan kerja, menurut teori jumlah kecelakaan kerja disebabkan 82% karena perilaku pekerja. Penelitian ini bertujuan untuk mengetahui hubungan tingkat pengetahuan keselamatan kerja dan pelatihan basic safety awareness terhadap safety behaviour dengan menggunakan Perkasa Learn di PT Putra Perkasa Abadi jobsite PT Bukit Asam Tbk. Metode yang digunakan pada penelitian ini adalah dengan menggunakan populasi yang digunakan dalam penelitian ini adalah pekerja non staff dengan jumlah 678 orang. Teknik sampling yang digunakan adalah simple random sampling dengan margin error 15%, sehingga didapatkan jumlah sampel 42 orang. Analisis yang digunakan adalah analisis univariat dan bivariat dengan uji Somers’d. Hasil penelitian adalah dilakukan pada karyawan non-staff PPA-BA terkait variable pengetahuan pekerja tentang keselamatan kerja, digolongkan menjadi 3 kategori yaitu baik, cukup dan kurang baik. Hasil penelitian menunjukkan dari 42 responden terdapat 34 (81%) orang yang berpengetahuan baik, 6 (14%) orang yang berpengetahuan cukup dan 2 (5%) orang berpengetahuan kurang baik. Kesimpulan penelitian ini adalah bahwa terdapat hubungan antara pelatihan basic safety awareness dengan safety behavior pada pekerja non-staff PPA-BA, yang ditunjukkan dengan nilai p-value sebesar 0,003109 dimana hasil ini <0,05 dan dengan nilai kekuatan korelasi sangat kuat sebesar 0,942857.
Deteksi Boraks Pada Bakso Di Kota Kupang Dengan Menggunakan Rapid Test Kit Boraks
Authors: Ati Winarti Delfiana , Sulmiyati Sulmiyati , Armadianto Heri , Sipahelut Geertruida M. 
Published: July 2024

Boraks merupakan zat kimia yang tidak termasuk sebagai bahan tambahan pangan namun beberapa kali digunakan dalam pembuatan bakso. Penelitian ini bertujuan, 1) untuk membandingkan hasil bakso yang terdeteksi dengan menggunakan rapid test kit boraks, uji organoleptik, dan uji penegasan, uji pH boraks, 2) untuk mengetahui penggunaan boraks pada pedagang bakso yang tersebar di kota Kupang. Penelitian ini telah dilaksanakan di Laboratorium Teknologi Hasil Ternak Peternakan Undana. Metode penelitian yang digunakan adalah menggunakan metode survey. Variabel yang diamati adalah deteksi boraks dengan rapid test kit boraks, uji organoleptik, uji penegasan, dan uji pH. Hasil penelitian menunjukkan hasil uji laboratorium terhadap 25 sampel bakso yang diambil pada pedagang di kota Kupang menggunakan rapid test kit boraks terdapat 5 (20%) sampel bakso yang terdeteksi boraks dari hasil uji rapid test kit boraks, hasil uji organoleptik menunjukkan bahwa warna, aroma, tekstur, tidak ada perbedaan antara bakso yang terdeteksi boraks sedangkan rasa terdapat perbedaan (P<0,05), uji penegasan menunjukkan bahwa tidak ada perbedaan antara bakso yang terdeteksi dan yang tidak terdeteksi, dan uji pH menunjukkan bahwa tidak ada perbedaan antara yang terdeteksi boraks dan yang tidak terdeteksi boraks. Berdasarkan hasil pembahasan maka disimpulkan bahwa hasil uji laboratorium 25 sampel bakso yang diambil pada pedagang di Kota Kupang menggunakan rapid test kit boraks terdapat 5 sampel bakso yang terdeteksi boraks dan 20 yang tidak terdeteksi boraks. Hasil uji organoleptik menunjukkan bahwa dari keempat kriteria yang berpengaruh nyata adalah dari segi rasa karena nilai P<0,05. Uji penegasan dan uji pH tidak bisa mendeskripsikan bakso tersebut positif boraks atau tidak karena kadar boraks yang dipakai sedikit dan hanya untuk membuat bakso tersebut terasa kenyal.
Modern approaches to the creation of 2D and 3D cellular models for the study of lung fibrosis
Authors: Tolstoluzhinskaya A. E. , Basalova N. A. , Efimenko A. Y. 
Published: July 2024

Lung fibrosis is a consequence of many influences leading to damage to lung tissue and the development of subsequent inflammation. Fibrosis is an overgrowth of connective tissue, which can lead to a violation of the architectonics of the lungs and reduce their functionality up to a fatal outcome. At the same time, the mechanisms underlying fibrogenesis are currently insufficiently studied. In this regard, the task of studying them does not lose its relevance, and its solution requires the development of models of lung fibrosis that can reflect all the key processes of fibrogenesis.The in vivo model using animals has multiple undeniable advantages, but at the same time it has strict ethical limitations and does not reflect all the mechanisms of lung fibrosis inherent in the human body. At the same time, in vitro research, scientists can afford to use biomaterials not only of animals, but also of humans, and build cellular systems based on them — from 2D to 3D models. Modeling of pulmonary fibrosis is mainly based on the use of the main types of cells involved in the development of pulmonary fibrosis, such as myofibroblasts, fibroblasts, alveolocytes and others. Some models are also based on a specific fibrosis-associated extracellular matrix and further study of the interaction of cells with each other and with the matrix. It should be borne in mind that different models display individual nuances of the native processes of lung fibrogenesis, which requires the research community to use a wide range of models. Taking into account the multifactorial pathogenesis of pulmonary fibrosis, it is important to understand the totality of the processes taking place in order to obtain the completeness of the real picture, close to the picture in vivo, and therefore the multicomponence of models is important. This review focuses on the analysis of various models of lung fibrosis in vitro in two-dimensional and three-dimensional systems, shows approaches to their creation, key differences, main advantages and disadvantages of models, both particular and general.
Nghiên cứu nhiệt phân nhựa tái chế từ rác sinh hoạt để sản xuất nhiên liêu
Authors: Van Dinh Son Tho  
Published: July 2024

Waste plastic originates from different sources. Currently, plastic mixed with solid municipal waste is separated for recycling and incineration. Waste plastic is derived from crude oil and can be converted into fuel by pyrolysis. This study conducted experiments on pyrolysis of plastic at 500oC, which was separated from household waste, and evaluated the properties of pyrolysis oil. Using FCC waste catalyst to improve the clouding point of pyrolysis oil products has been measured and discussed. Based on an experimental data, a process for plastic pyrolysis combination with vapor cracking unit is proposed and adapted to the infranstructure of a waste treatment plant in Central Vietnam
Peran Badan Permusyawaratan Desa (BPD) Dalam Pelaksanaan Kebijakan Vaksinasi Covid-19
Authors: Oratmangun Alfalyan Paschalis 
Published: July 2024

Tujuan penelitian ini adalah 1) Mengetahui Peran Badan Permusyawaratan Desa (BPD) dalam pelaksanaan Vaksinasi Covid-19 di Desa Sumbersekar Kecamatan Dau Kabupaten Malang; 2) Mengetahui Wewenang Badan Permusyawaratan Desa (BPD) dalam pelaksanaan Vaksinasi Covid-19 di Desa Sumbersekar Kecamatan Dau Kabupaten Malang; 3) mengetahui Hak dan Tanggung Jawab Badan Permusyawaratan Desa (BPD) dalam pelaksanaan Vaksinasi Covid-19 di Desa Sumbersekar Kecamatan Dau Kabupaten Malang; 4) Mengetahui Faktor – faktor yang mempengaruhi Peran Badan Permusyawaratan Desa (BPD) dalam pelaksanaan Vaksinasi Covid-19 di Desa Sumbersekar Kecamatan Dau Kabupaten Malang. Hasil penelitia diperolah kesimpulan. 1) Peran Badan Permusyawaratan Desa (BPD) di Desa Sumbersekar Kecamatan Dau Kabupaten Malang yaitu A.Menggerakan perangkat pemerintah desa untuk megsosialisai masyarakat dalam pelaksanaan Vaksinasi Covid-19, B.Mengayomi dan mendorong partisipasi masyarakat dalam pengenalan vaksinasi, C. Terlibat dalam membantu Pemerintah Pusat untuk mengsukseskan vaksinasi bagi penduduk Indonesia, D.Mengkoordinir pelaksanaan vaksinasi covid-19; 2) Wewenang dalam pelaksanaan kegaiatan vaksinasi covid-19 di Desa Sumbersekar kecamatan Dau kabupaten Malang yaitu: A. Memberikan pengarahan kepada bawahan atau masyarakat, B.Menggali, menampung, menghimpun, merumuskandan menyalurkan aspirasi masyarakat, C.Mengawasi pelaksanaan kegiatan vaksinasi covid-19, D.Mengambil keputusan dalam proses pelaksanaan kegaiatan vaksinasi covid-19; 3) Hak dan Tanggung jawab BPD (Badan Permusyawaratan Desa) lembaga legislatif mempunyai hak dan tanggung jawab dalam membuat suatu kebijakan. Kebijakan yang di buat oleh BPD berupa peraturan desa atau ketentuan desa yang di berlakukan bagi segenap warga masyarakat di desa, sama halnya dengan pelaksanaan vaksinasi covid-19 adalah salah satu hak dan tanggung jawab BPD karena BPD berperan sebagai pelayan masyarakat.
Potensi Pengembangan Pangan Ikan Haruan Sebagai Ikan Lokal Kalimantan Tengah melalui Perbaikan Sistem P4t1 di Era Milenial
Authors: Prisca Pricilla Chintya , Nedik Mira , Pebti Fauziah Lutfiatul 
Published: July 2024

Kalimantan Tengah merupakan salah satu provinsi terbesar yang berada di Pulau Kalimantan yang berbatasan langsung dengan laut Jawa. Pulau Kalimantan terkenal dengan banyaknya sungai yang ada. Di berbagai daerah di Kalimantan Tengah juga memiliki banyak anak sungai. Sehinga, sumber daya perikanan yang ada di Kalimantan Tengah sangatlah melimpah. Menurut data BPS Provinsi Kalteng tahun 2016 total produksi pengolahan perikanan Kalimantan Tengah sebesar 5,4 juta ton. Pada tahun 2016 unit pengolahan hasil perikanan Kalimantan Tengah berjumlah 2.466 unit dengan berbagai macam jenis pengolahan seperti penggaraman, pemindangan, fermentasi, dan pengasapan. Di era milenial seperti sekarang ini minat masyarakat untuk mengkonsumsi ikan juga bervariatif. Masyarakat lebih suka mengkonsumsi ikan dalam bentuk olahan seperti nugget, bakso, ikan kalengan, kerupuk, maupun jenis olahan ikan lainnya. Sehingga untuk menarik minat konsumen dalam mengkonsumsi ikan terutama ikan haruan sebagai ikan lokal Kalimantan Tengah diperlukan sebuah strategi produksi yang diperankan oleh para milenial yang dapat berkontribusi aktif dalam pengembangan pangan lokal melalui produk olahan ikan yang berdaya saing tinggi. Salah satu strategi yang dapat diterapkan dalam meningkatkan pangan ikan lokal yaitu P4T1 (Product, Price, Packaging, Promotion and Taste). Melalui desain ini, diharapkan adanya peningkatan pangan lokal khususnya ikan haruan sebagai ikan lokal daerah.
Кодекс безопасности рыбаков и рыболовных судов 2005 года: Часть А
– Практика в области безопасности и гигиены труда
Authors:   Международная морская организация
Published: July 2024

The revised Code was approved by the Maritime Safety Committee (MSC) at its seventy-ninth session in 2004, by the FAO Committee on Fisheries at its twenty-sixth session in 2005 and by the Governing Body of International Labour Organization (ILO) at its 293rd Session in 2005. It is divided into two parts (sold separately):

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Part A – Safety and Health Practices for Skippers and Crews, 2005

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Part B – Safety and Health Requirements for the Construction and Equipment of Fishing Vessels, 2005
Código de Seguridad para Pescadores y Buques Pesqueros 2005: Parte A – Directrices Prácticas de Seguridad e Higiene
Authors:   Organización Marítima Internacional
Published: July 2024

The revised Code was approved by the Maritime Safety Committee (MSC) at its seventy-ninth session in 2004, by the FAO Committee on Fisheries at its twenty-sixth session in 2005 and by the Governing Body of International Labour Organization (ILO) at its 293rd Session in 2005. It is divided into two parts (sold separately):

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Part A – Safety and Health Practices for Skippers and Crews, 2005

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Part B – Safety and Health Requirements for the Construction and Equipment of Fishing Vessels, 2005
اتفاقية ماربول
Authors:   International Maritime Organization
Published: July 2024

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<p>تُعنى الاتفاقية الدولية لمنع التلوث من السفن لعام 1973 (اتفاقية ماربول) بالحفاظ على البيئة البحرية عبر الحيلولة دون تلوثها بالزيت وسائر المواد الضارة والتخفيف إلى الحد الأدنى من التسرُّب العرَضَي لهذه المواد. وتُعرَض الجوانب الفنية لهذه الاتفاقية في ستة مرفقات، اعتُمدت المرفقات الخمسة الأولى منها بموجب اتفاقية عام 1973، في صيغتها المعدلة ببروتوكول عام 1978 . وتتناول هذه المرفقات مسائل تلوث البحار من جراء الزيت والمواد الضارة السائلة السائبة والمواد الضارة المعبّأة المنقولة بحراً وقاذورات مجارير السفن والقمامة من السفن. واعتُمد المرفق VI ببروتوكول آخر في عام 1997، وهو يتناول تلوث الهواء من جراء السفن.</p>
<p>وتقدم الطبعة الجامعة لعام 2022 مرجعاً سهلاً و شاملاً إلى آخر الأحكام المحدَّثة من مواد اتفاقية ماربول ومن تفسيراتها الموحدة وبروتوكولاتها ومرفقاتها، مع إدراج كل التعديلات التي اعتمدتها لجنة حماية البيئة البحرية (MEPC) التي دخلت حيّز النفاذ اعتباراً من 1 تشرين الثاني/ نوفمبر 2022.</p>
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