bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between preoperative serum cholinesterase and all-cause mortality in geriatric patients with hip fractures: a cohort study of 2387 patients
Authors: Zhang Yan-Ning , Xiao Peng , Zhang Bin-Fei 
Published: July 2024

Abstract
Objective
This study is to evaluate the association between preoperative cholinesterase levels and all-cause mortality in geriatric hip fractures.

Methods
Elderly patients with hip fractures were screened between Jan 2015 and Sep 2019. Demographic and clinical characteristics of patients were collected. Linear and nonlinear multivariate Cox regression models were used to identify the association between preoperative cholinesterase levels and mortality in these patients. Analyses were performed using EmpowerStats and the R software.

Results
Two thousand three hundred eighty-seven patients were included in this study. The mean follow-up period was 37.64 months. Seven hundred eighty-seven (33.0%) patients died due to all-cause mortality. Preoperative cholinesterase levels were 5910 ± 1700 U/L. Linear multivariate Cox regression models showed that preoperative cholinesterase level was associated with mortality (HR = 0.83, 95% CI: 0.78–0.88), P < 0.0001) for every 1000 U/L. However, the linear association was unstable, and nonlinearity was identified. A cholinesterase concentration of 5940 U/L was an inflection point. When preoperative cholinesterase level < 5940 U/L, the mortality decreased by 28% for every 1000 U/L increase in cholinesterase (HR = 0.72, 95%CI: 0.66–0.79, P < 0.0001). When cholinesterase was > 5940 U/L, the mortality was no longer decreased with the rise of cholinesterase (HR = 1.01, 95%CI: 0.91–1.11, P = 0.9157). We found the nonlinear association was very stable in the propensity score-matching sensitive analysis.

Conclusions
Preoperative cholinesterase levels were nonlinearly associated with mortality in elderly hip fractures, and cholinesterase was a risk indicator of all-cause mortality.

Trial registration
This study is registered on the website of the Chinese Clinical Trial Registry (ChiCTR: ChiCTR2200057323) (08/03/2022).
Use of colloids and crystalloids for perioperative clinical infusion management in cardiac surgery patients and postoperative outcomes: a meta-analysis
Authors: Chen Shan-Dong , Ma Yu-Tong , Wei Hui-Xia , Ou Xin-Rong , Liu Jia-Yi , Tian Ya-Lan , Zhang Chao , Xu Yun-Jin , Kong Yao 
Published: July 2024

Abstract
Background
The optimal fluid management strategy for patients undergoing cardiac surgery was controversial regarding fluid volume and intraoperative fluid types. This study aimed to assess the correlation between colloids and crystalloids used for perioperative fluid therapy in cardiac surgery patients and postoperative prognosis.

Methods
The Ovid MEDLINE(R) ALL, Embase, and Cochrane Central Register of Controlled Trials databases were searched for eligible studies on fluid management strategies using colloids and crystalloids for cardiac surgery patients published before August 25th, 2023.

Results
Ten randomized controlled trials met the eligibility criteria. Compared to the use of crystalloids, the use of colloids, including hydroxyethyl starch (HES), albumin, and gelatine, did not show any differences in mortality, transfusion, acute kidney injury, and atrial fibrillation rates, postoperative blood loss, the length of hospital stay, or the length of intensive care unit (ICU) stay. The results of this meta-analysis showed that the crystalloid group had significantly reduced postoperative chest tube output compared to the colloid group. In the subgroup analysis, the amount of fresh frozen plasma (FFP) infused was significantly lower when using fluid management in the ICU and when using isotonic crystalloids compared to the colloids. In addition, when using fluid management in the ICU, patients in the colloid group had a significant increase in urine volume 24 h after surgery. However, other related factors, including the type of crystalloid solution, type of colloidal solution, and timing of liquid management, did not affect most outcomes.

Conclusion
Both colloids and crystalloids could be used as alternatives for perioperative fluid management after cardiac surgery. The use of crystalloids significantly reduced the postoperative chest tube output, and the need for FFP infusion decreased significantly with the use of isotonic crystalloids or fluid management during the ICU stay. ICU patients in the colloid group had higher urine output 24 h after surgery. In addition, although the infusion method was not related to most outcomes, the rates of red blood cell and FFP transfusion and postoperative blood loss in the crystalloid group seemed to be lower, which needed to be further studied in high-quality and large-sample RCTs.

Trial registration
PROSPERO, CRD42023415234.
What influences user continuous intention of digital museum: integrating task-technology fit (TTF) and unified theory of acceptance and usage of technology (UTAUT) models
Authors: Zheng Feiyu , Wu Shan , Liu Ren , Bai Yiqun 
Published: July 2024

Abstract
Digital museums play a crucial role in facilitating users' access to and exploration of digital cultural heritage resources. However, exploring the factors influencing user engagement with these digital museums from a user experience perspective remains essential. This study evaluates the factors driving user continuous behavioral intention towards the digital museum of Beijing’s central axis, integrating the new task-technology fit (TTF) and the new unified theory of acceptance and use of technology (UTAUT) models, and introducing perceived enjoyment, design aesthetics, and perceived cultural value as additional variables. Analyzing survey data (n = 377) utilizing structural equation modeling (SEM), the study identifies the following key findings: (1) the task and technology characteristics of digital museums significantly impact the TTF; (2) performance expectancy, effort expectancy, design aesthetics, perceived enjoyment, and perceived cultural value all positively impact user continuous behavioral intention; (3) the technological characteristics of digital museums were observed to positively impact users' effort expectancy; but (4) the TTF and social influence did not have no significant impact the user continuous behavioral intention. These findings offer valuable insights into the factors driving users' continuous behavioral intention to use digital museums of cultural heritage, offering practical guidance for future development and optimization of these digital museums, and highlighting specific implications and suggestions for enhancing the user experience.
Modified ILM flap techniques versus classical inverted ILM flap technique for large macular holes: a systematic review and meta-analysis of randomized controlled trials
Authors: Alghamdi Sarah A. , Aljahdali Faisal F. , Sharif Rahaf K. , Homsi Jumanah J. , Alzahrani Asma A. , Alomari Lugean K. , Abukhashabah Amro 
Published: July 2024

Abstract
Background
Macular holes (MHs) constitute a vitreoretinal interface disorder that occurs when structural abnormalities in the fovea lead to impaired central vision. The standard treatment for MHs is mainly surgical. Using an inverted internal limiting membrane (ILM) flap has enhanced the success rates of MH surgeries. This systematic review and meta-analysis aimed to compare the classical inverted ILM flap technique to modified ILM flap techniques for managing large MHs.

Methods
We searched Medline, Embase, and CENTRAL. We included randomized controlled trials (RCTs) that compared the classic inverted ILM flap technique to modified ILM flap techniques as initial surgical treatment of eyes with large MHs of more than 400 microns. We sought to evaluate the following outcomes: (1) MH closure. (2) Best-corrected visual acuity (BCVA). (3) Foveal closure type (4) Rate of ellipsoid zone (EZ) defects and external limiting membrane (ELM) defects. The standardized mean difference (SMD) was used to represent continuous outcomes, while the risk ratio (RR) was used to represent dichotomous outcomes.

Results
Four RCTs that enrolled 220 participants were deemed eligible. The analysis revealed no statistically significant differences in MH closure between both groups (95% CI: 0.20, 7.96; P = 0.81). No statistically significant differences in mean BCVA were found at 1 and 3 months between both groups (SMD: 0.04; 95% CI: −0.16, 0.23; P = 0.70 and SMD: −0.167; 95%CI: −1.240, 0.906; P = 0.760, respectively). In addition, there were no significant differences between the two groups in the pattern of foveal closure, namely U-shape, V-shape, and flap open at 3, 6, and 12 months (RR: 0.87; 95% CI: 0.67, 1.12; P = 0.28, RR: 0.96; 95% CI: 0.58, 1.61; P = 0.89, and RR: 1.95, 95% CI: 0.26, 14.50; P = 0.51, respectively). Finally, the analysis showed no statistically significant difference in both groups’ EZ and ELM defect rates at 3, 6, and 12 months (RR: 1; 95% CI: 0.85; 1.18: P = 1 and RR: 1.14; 95% CI: 0.90, 1.45; P = 0.27).

Conclusion
Macular holes (MHs) constitute a vitreoretinal interface disorder that occurs when structural abnormalities in the fovea lead to impaired central vision. The standard treatment for MHs is mainly surgical. Using an inverted internal limiting membrane (ILM) flap has enhanced the success rates of MH surgeries. This systematic review and meta-analysis aimed to compare the classical inverted ILM flap technique to modified ILM flap techniques for managing large MHs.
The development and implementation of trauma, posttraumatic growth and trauma-informed rehabilitation course for psychiatric personnel-case study
Authors: Mazor Y. , Ezra A. , Hadas-Lidor N. 
Published: July 2024

Introduction
The National School for Training in Mental Health Rehabilitation and Recovery at the Ono academic college operates under the auspices of, and is funded by, the Division for Mental Health Rehabilitation of the Israeli Ministry of Health. Intended to hone the quality of services provided, it offers numerous training courses, that target various populations associated with and working in the field of mental health recovery, among them clients and their family members, as well rehabilitation professionals and support personnel. The novel course of trauma and posttraumatic growth (PTG) was developed and aimed at supporting recovery, coping strategies and ultimately PTG through the lenses of both recovery and trauma informed care for psychiatric and support personnel, professionals with lived experience, and family members. It is built of eleven six hours long sessions with lectures, in-vivo assignments, and group supervision.

Objectives
Portray the development, implementation, and outcomes of the course from psycho-educational, clinical, social, and personal perspectives of students as well as the course’s developers.

Methods
A case study of the course that will be portrayed through qualitative anonymous testimonials from students’ surveys and assignments, as well as the analyses of processes that the course underwent through the years.

Results
The course has several dimensions that allow the integration between trauma, recovery, and PTG in psychiatric rehabilitation: the integration between academia and research-based knowledge with experiential knowledge; integration between the perspectives of PTG and recovery; and, integration between social and cultural perspectives and person-centred care. In addition, the course promotes trauma-informed models in psychiatric rehabilitation; offers new perspective and implantation to psychiatric recovery-oriented tools so as to promote PTG; and enhances social support and cohesion within mental health services and personnel.

Conclusions
The current case study portrays the unique processes of knowledge development, implementation, and training in psychiatric rehabilitation personnel, supported staff and people with lived experience. The course brings a focus on PTG as a promising addition to the trauma-informed approach in psychiatric rehabilitation, which is only scarcely linked to recovery.

Disclosure of Interest
None Declared
Novel approach of prophylactic radiation to reduce toxicities comparing 2-step 40 Gy with 56 Gy simultaneous integrated boost intensity-modulated radiation therapy for locally advanced squamous cell carcinoma of the head and neck: A phase III trial (JCOG1912, NEW BRIDGE).
Authors: Yokota Tomoya , Zenda Sadamoto , Kodaira Takeshi , Kiyota Naomi , Fujimoto Yasushi , Wasano Koichiro , Takahashi Ryo , Mizowaki Takashi , Homma Akihiro , Sasaki Keita , Machida Ryunosuke , Sekino Yuta , Fukuda Haruhiko 
Published: July 2024

TPS6121 Background: Chemoradiotherapy (CRT) with concurrent cisplatin is the standard of care as a nonsurgical definitive treatment for patients with locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). However, CRT is associated with increased severe late adverse events, including swallowing dysfunction, xerostomia, ototoxicity, and hypothyroidism. Few strategies aimed at less invasive CRT without compromising treatment outcomes have been successful. The purpose of this study is to confirm the non-inferiority of reduced dose prophylactic radiation with 40 Gy compared to standard dose prophylactic radiation with 56 Gy in terms of the time to treatment failure (TTF) among patients with clinical stage III-IVB LA-SCCHN. Methods: This study is a multicenter, two-arm, open-label, randomized phase III trial. The main inclusion criteria are as follows: (i) Primary lesions are located in the oropharynx, hypopharynx, or larynx. (ii) Histologically proven SCC on biopsy specimens of the primary lesion. Immunohistochemistry reveals p16 negativity in patients with oropharyngeal cancer. (iii) Clinical stage of III, IVA, or IVB (excluding N3a) based on the 8th UICC-TNM classification. Patients are randomized to the standard arm or experimental arm. A total dose of 70 Gy for tumors with concurrent cisplatin at 100 mg/m2 are administered in both arms. For prophylactic field, patients in the standard arm receive a total dose of 56 Gy in 35 fractions for 7 weeks using simultaneous integrated boost (SIB56) and those in the experimental arm receive 40 Gy in 20 fractions using two-step methods for 4 weeks (2-step40). A total of 400 patients will be enrolled from 52 Japanese institutions within 5 years. The primary endpoint is TTF, and the secondary endpoints are overall survival, complete response rate, progression-free survival, locoregional relapse-free survival, acute and late adverse events, quality of life score, and swallowing function score.Patient accrual was started in May 2021 and the study is now open for accrual. A total of 186 patients have been enrolled as of January 2024. This trial has been registered in the Japan Registry of Clinical Trials as jRCTs031210100. Clinical trial information: jRCTs031210100 .
Evaluating the Performance of Two Automated Anti-drug Antibodies Assays for Infliximab and Adalimumab Without Acid Dissociation
Authors: Karsten Carley , Grannas Karin , Bergman Oskar , Movérare Robert , Roforth Matthew , Willrich Maria Alice V. , Snyder Melissa R. , Yang Yifei K. 
Published: July 2024

AbstractMonitoring anti-drug antibodies (ADAs) to infliximab and adalimumab is critical to treatment management in various autoimmune disorders. The growing need for proactive therapeutic monitoring further requires the detection of ADAs in the presence of measurable concentrations of infliximab or adalimumab. To provide robust analytical assays for clinical application, we evaluated two automated immunoassays developed using ImmunoCAP™ technology and based on the bridging format to measure serum ADAs to infliximab and adalimumab respectively. Without an acid-dissociation step, these research prototype assays can detect a positive control monoclonal ADA towards infliximab and adalimumab, ranging from < 25 ng/ml to 10,000 ng/mL. Both assays exhibit imprecision less than 20% at different ADA titer levels and can distinguish ADAs towards different drug targets. In method comparison using authentic patient samples, the quantitative results of the ADA assays are not directly comparable to two existing clinical immunoassays for ADAs (correlation coefficient rs = 0.673 for infliximab ADAs; rs = 0.510 for adalimumab ADAs), presumably due to the lack of commutable ADA standards and the polyclonal nature of ADAs. Nevertheless, there is qualitative agreement between the methods when evaluating putative positive and negative patient samples (overall agreement 0.83 for infliximab ADAs; 0.76 for adalimumab ADAs). Biotin and high levels of rheumatoid factors may interfere with the performance of the automated assays due to competitive binding with the biotinylated drug and non-specific formation of bridging complexes. The two ImmunoCAP assays can provide new analytical methods for proactive therapeutic monitoring of adalimumab and infliximab.
Graphical Abstract
Pathogenesis, diagnosis and current treatment of prolactinoma: a review of the literature
Authors: Szyszka Monika , Kruszewski Adrian , Kucharska Maja , Dąbrowska Anna , Błaszczak Karolina , Paduszyńska Natalia , Przybysz Paulina 
Published: July 2024

ABSTRACT:
Prolactinoma is a benign tumor of the pituitary gland that leads to the overproduction of prolactin. It is the most common type of pituitary adenoma, accounting for approximately 50% of all pituitary tumors. The clinical presentation of prolactinoma varies depending on the level of prolactin elevation and the size of the tumor. In women, common symptoms include galactorrhea, amenorrhea, and infertility. Men may present with hypogonadism, decreased libido, erectile dysfunction, and gynecomastia. Large prolactinomas, known as macroadenomas, can cause mass effects such as headaches, visual disturbances due to compression of the optic chiasm, and hypopituitarism due to pressure on surrounding pituitary tissue. Understanding the pathogenesis of prolactinoma is crucial for developing effective treatments and improving patient outcomes. The development of prolactinomas involves a complex interplay of genetic, hormonal, and cellular factors. Treatment of prolactinoma aims to normalize prolactin levels, reduce tumor size, and alleviate symptoms. The first-line therapy is dopamine agonists, such as cabergoline and bromocriptine, with surgery and radiotherapy reserved for refractory cases. Furthermore, chemotherapeutic agent - temozolomide may be a treatment of choice in aggressive or malignant prolactinomas. By understanding the underlying mechanisms and different treatment methods, healthcare providers can optimize the management and outcomes for patients with prolactinoma.
Destroying Phantom Jams with Connectivity and Automation: Nonlinear Dynamics and Control of Mixed Traffic
Authors: Molnar Tamas G. , Orosz Gábor 
Published: July 2024

Connected automated vehicles (CAVs) have the potential to improve the efficiency of vehicular traffic. In this paper, we discuss how CAVs can positively impact the dynamic behavior of mixed traffic systems on highways through the lens of nonlinear dynamics theory. First, we show that human-driven traffic exhibits a bistability phenomenon, in which the same drivers can both drive smoothly or cause congestion, depending on perturbations like a braking of an individual driver. As such, bistability can lead to unexpected phantom traffic jams, which are undesired. By analyzing the corresponding nonlinear dynamical model, we explain the mechanism of bistability and identify which human driver parameters may cause it. Second, we study mixed traffic that includes both human drivers and CAVs, and we analyze how CAVs affect the nonlinear dynamic behavior. We show that a large-enough penetration of CAVs in the traffic flow can eliminate bistability, and we identify the controller parameters of CAVs that are able to do so. Ultimately, this helps to achieve stable and smooth mobility on highways. History: This paper has been accepted for the Transportation Science Special Issue on ISTTT25 Conference. Funding: This work was supported by the University of Michigan’s Center for Connected and Automated Transportation [U.S. DOT Grant 69A3551747105]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/trsc.2023.0498 .
Anxiety and associated factors among medical and surgical patients in Ethiopia: A systematic review and meta-analysis
Authors: Rtbey Gidey , Mihertabe Milen , Andualem Fantahun , Melkam Mamaru , Takelle Girmaw Medfu , Tinsae Techilo , Fentahun Setegn 
Published: July 2024

Background
Individuals diagnosed with chronic medical conditions and patients appointed to undergo surgery face various degrees of anxiety as a result of doubts related to the outcome of surgery, and the psycho-socioeconomic costs of the medical illness. This can affect the treatment process and even the outcome of patients with medical and surgical cases. Though different studies were conducted on anxiety and associated factors among medical and surgical patients in Ethiopia, the findings were found to be inconsistent and had a wide discrepancy. So, this systematic review and meta-analysis estimated the pooled effect size of anxiety among this population and guides to plan appropriate intervention at a national level.

Methods
Studies conducted on anxiety and associated factors among medical and surgical patients in Ethiopia were included. Data was extracted using Microsoft Excel and analyzed using STATA version 11. The random-effects model was used to estimate the pooled effect size of anxiety and its determinants with 95% confidence intervals. Funnel plots and Egger’s regression tests were employed to check publication bias. Sub-group and sensitivity analyses were also conducted.

Results
The pooled prevalence of anxiety among medical and surgical patients in Ethiopia was found to be 48.82% with a 95% CI (42.66, 54.99). Being female[OR = 2.84(2.02, 4.01)], fear of death [OR = 2.93(1.57, 5.50)], and history of surgery[OR = 0.42(0.27, 0.065)], among surgical patients and being female[OR = 2.35(1.94, 2.850], having poor social support[OR = 2.22(1.62, 3.05)], perceived stigma[OR = 4.25(1.97, 9.18)] and family history of mental illness[OR = 1.86(1.21, 2.86)] among medical patients were significantly associated with anxiety in this systematic review and meta-analysis.

Conclusion and recommendation
The pooled prevalence of anxiety among medical and surgical patients in Ethiopia was found to be high. Therefore, it would be good for professionals to screen patients for anxiety besides managing their medical or surgical cases to detect them early and address them.