bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rationale and design of the MGuard for acute ST elevation reperfusion MASTER trial
Authors: Costa J. Ribamar , Abizaid Alexandre , Dudek Dariusz , Silber Sigmund , Leon Martin B. , Stone Gregg W. 
Published: September 2012

BackgroundPrimary percutaneous coronary intervention (PCI) improves survival compared with thrombolytic therapy in ST‐segment elevation myocardial infarction (STEMI), with much of the benefit attributable to greater rates of normal epicardial and myocardial perfusion resulting in enhanced myocardial salvage. However, reduced tissue reperfusion after primary PCI may occur from distal thromboemboli with capillary plugging. The MGuard stent consists of a balloon‐expandable metallic scaffold with mesh sleeve fibers of polyethylene terephthalate attached to its outer surface to trap friable debris/thrombi and reduce distal embolization. The MGuard for Acute ST Elevation Reperfusion (MASTER) trial has been designed to evaluate the MGuard stent in patients with STEMI.Study DesignThe MASTER trial is a prospective, multicenter, randomized study designed to compare the incidence of complete (=70%) ST‐segment resolution with PCI using bare metal or drug‐eluting stents (the control arm) versus PCI with the MGuard stent, measured 60 to 90 min after the last angiogram (primary endpoint). Secondary endpoints include the rates of TIMI flow and myocardial blush, and clinical outcomes through 1‐year follow‐up. The study has enrolled 432 patients with STEMI undergoing primary or rescue angioplasty within 12 hr of symptom onset and includes substudies with cardiac magnetic resonance imaging and quantitative coronary angiography to evaluate infarct size, microvascular obstruction, and angiographic restenosis.ConclusionsDistal embolization is common during primary PCI and results in reduced myocardial perfusion and lack of reduction of infarct size. The MASTER trial is a prospective, randomized trial designed to assess the potential of the novel MGuard stent with protective mesh net to reduce embolization and enhance myocardial reperfusion compared with routine PCI in the setting of STEMI. © 2013 Wiley Periodicals, Inc.
Single‐center comparative outcomes of the edwards SAPIEN and medtronic melody transcatheter heart valves in the pulmonary position
Authors: Faza Nadeen , Kenny Damien , Kavinsky Clifford , Amin Zahid , Heitschmidt Mary , Hijazi Ziyad M. 
Published: September 2012

BackgroundTwo transcatheter pulmonary valve replacement (tPVR) systems (Edwards SAPIEN and Medtronic Melody) are available; however, comparative studies evaluating outcome data are lacking. The aim of this study was to compare short‐ with medium‐term outcome data of these valves in the pulmonary position from a single institution.MethodsRetrospective data analysis of all patients undergoing tPVR from April 2008 until April 2012. Pre‐procedural investigations, patient demographics, procedural hemodynamics, and clinical and echocardiographic follow‐up data were included. Data are presented as mean ± standard deviation.ResultsThirty‐three patients underwent successful tPVR (SAPIEN (S) n = 20, Melody (M) n = 13). Patient age and weight were similar between the two groups. Primary indication included regurgitation (S (n = 2), M (n = 3)), stenosis (S (n = 13), M (n = 7)), or mixed (S (n = 5), M (n = 3)). There was no difference in pre‐procedural peak Doppler gradients across the pulmonary outflow (S = 47.73 ± 21.14 mm Hg, M = 42.62 ± 15.59 mm Hg, P = 0.46). All but one patient underwent pre‐stenting prior to valve implantation. Immediately following valve deployment, the transvalvar gradient was not statistically different between the two groups (S = 11.5 ± 8.07 mm Hg, M = 8.15 ± 4.56 mm Hg, P = 0.18). There were no procedural deaths. Follow‐up mean pulmonary Doppler gradients were higher with the SAPIEN cohort (18.43 ± 9.06 mm Hg (S) and 11.17 ± 5.24 mm Hg (M), P = 0.016); however, no differences were seen when similar procedural epochs were assessed. All but one patient remained with PR grade = 2.ConclusionsIn a single‐center series, the SAPIEN and Melody valves demonstrated comparable medium‐term valve function. Greater residual gradients with the SAPIEN valve may represent a more conservative early pre‐stenting approach with this valve. © 2012 Wiley Periodicals, Inc.
Recent Advances in Asymmetric Counteranion‐directed Catalysis (ACDC)
Authors: Ávila Eloah P. , Amarante Giovanni W. 
Published: September 2012

AbstractAs expected, chemists have dedicated efforts in the development of asymmetric catalytic reactions based on lessons from nature. The decisive presence of the chiral anions in many natural chiral catalysts inspires the design of new asymmetric catalytic systems based on them. Thus, in this Minireview the recent contributions of asymmetric counteranion‐directed catalysis (ACDC) are reported. Discussions about development of new concepts, designed of catalysis and application of them in different reactions also are exposed.
Modeling of CO2‐Hydrate Formation at the Gas‐Water Interface in Sand Sediment
Authors: Takahashi T. , Sato T. , Inui M. , Hirabayashi S. , Brumby P. E. 
Published: September 2012

AbstractSub‐seabed geological storage of CO2 in the form of gas hydrate is attractive because clathrate hydrate stably exists at low temperature and high pressure, even if a fault occurs by diastrophism like a big earthquake. For the effective design of the storage system it is necessary to model the formation of CO2‐hydrate. Here, it is assumed that the formation of gas hydrate on the interface between gas and water consists of two stages: gas diffusion through the CO2‐hydrate film and consequent CO2‐hydrate formation on the interface, between film and water. Also proposed is the presence of a fresh reaction interface, which is part of the interface between the gas and aqueous phases and not covered with CO2‐hydrate. Parameters necessary to model the hydrate formation in sand sediment are derived by comparing the results of the present numerical simulations and the measurements in the literature.
Optimal Integration of Directly Combined Hydrophobic Interaction and Ion Exchange Chromatography Purification Processes
Authors: Helling C. , Borrmann C. , Strube J. 
Published: September 2012

AbstractHydrophobic interaction and ion exchange chromatography are basic steps in purification of fermentative biopharmaceuticals. An optimization by statistical design of experiments requires a huge amount of feed. An alternative approach is the combination of model parameter determination using small scale experimental model parameter determination (1‐mL columns) and rigorous process modeling. Applicability for the prediction of the separation of a fermentation mixture of CHO mammalian cell culture is validated and hence IgG is purified from cell culture supernatant. Hydrophobic interaction chromatography directly combined with ion exchange chromatography is optimized. Any direct integration of those two main unit operations in purification processes is a methodological first step towards total process optimization. The potential for cost reduction and overall yield improvement is demonstrated and this leads to the conclusion that single step optimization is a feigned and not a real optimum.
Uptake and Speciation of Inorganic Arsenic with Cellulose Fibre Coated with Yttrium Hydroxide Layer as a Novel Green Sorbent
Authors: An Myong‐Il , Zhang Xiaoxing , Yang Ting , Chen Mingli , Wang Jianhua 
Published: September 2012

AbstractA novel adsorbent was developed by coating yttrium hydroxide precipitate layer on cellulose fibre. This material takes upca. 98% of 5 µg·L−1As(III) and As(V) at low pH (pH<7), while a favorable selectivity for As(V) was achieved within pH 11–12. In practice, a mini‐column packed with Y(OH)3precipitate layer coated cellulose fibre particles was incorporated into a sequential injection system for selective uptake of arsenate at pH 11.5. The retained arsenate was afterwards recovered with 50 µL of 0.8 mol·L−1NaOH solution as eluent, followed by hydride generation in a reaction medium of 2.0 mol·L−1HCl and 1.0% NaBH4solution (W/V, in 0.5% NaOH) after pre‐reduction of arsenate to arsenite by KI‐ascorbic acid (5%,W/V), with detection by atomic fluorescence spectrometry. Total inorganic arsenic was quantitatively taken up at pH 6.0 by following the same procedure and arsenic speciation was performed by difference. With a sample volume of 1.0 mL, an enrichment factor of 16.4 was derived with a detection limit of 17 ng·L−1within a linear range of 0.05–2.0 µg·L−1. A relative standard deviation (RSD) of 2.6% (0.5 µg·L−1,n=11) was achieved. The procedure was validated by analyzing arsenic in a certified reference material GBW 09101 (human hair), and speciation of inorganic arsenic in natural water samples. The entire process requires no organic solvents, thus Y(OH)3coated cellulose fibre provides a green adsorbent.
Synthesis and Pressure‐induced Reversible Phase Transition of a Crystalline Solid Europium Germanate NaEuGeO4
Authors: Zhao Xinguang , Wang Kai , Yan Tingting , Yan Yan , Zou Bo , Yu Jihong , Xu Ruren 
Published: September 2012

AbstractThe crystalline solid europium germanate NaEuGeO4 was prepared under hydrothermal conditions. The in‐situ photoluminescence spectroscopic measurement and the synchrotron X‐ray diffraction analysis in a diamond anvil cell (DAC) under high pressure were performed to study the pressure‐induced phase transition of NaEuGeO4 as well as changes of the luminescent properties of Eu3+ ions. Photoluminescence spectroscopic studies revealed that a phase transition occurred at a pressure range of 6.5–10 GPa and the high‐pressure phase of NaEuGeO4 (NaEuGeO4‐HP) was still stable when the pressure raised up to about 20 GPa. As the pressure was released, the spectra returned to the original state, revealing that the pressure‐induced phase transition is a completely reversible process. The synchrotron X‐ray diffraction analysis demonstrated that the structure of NaEuGeO4 transformed to an unidentified phase NaEuGeO4‐HP at a pressure higher than 10 GPa, and the phase transition is reversible. This result is consisted with that obtained by photoluminescence spectra analysis.
Suzuki Reactions in Water Catalyzed by an Active and Reusable PMO‐Type Pd(II) Organometal Catalyst with Cage‐Like Mesoporous Structure
Authors: Zhu Fengxia , Li Hexing 
Published: September 2012

AbstractA novel Pd(II) organometal catalyst with three‐dimensional (3D) cage‐like Ia3d cubic mesoporous structure and high surface area was prepared. In comparison with the corresponding catalyst with two‐dimensional (2D) P6mm hexagonal mesoporous structure, the as‐prepared catalyst exhibited higher activities in the water‐medium Suzuki coupling reactions owing to the diminished diffusion limit. It showed comparable efficiencies with the Pd(PPh3)2Cl2 homogeneous catalyst and could be easily recycled and reused for five times without significant loss of activity.
Perfectly Green Organocatalysis: Quaternary Ammonium Base Triggered Cyanosilylation of Aldehydes
Authors: Wen Yeqian , Liang Mengwei , Wang Yiming , Ren Weimin , Lü Xiaobing 
Published: September 2012

AbstractQuaternary ammonium bases, such as aqueous (CH3)4NOH, were found to be an extraordinarily efficient catalyst for cyanosilylation of aldehydes. The addition reaction of trimethylsilyl cyanide (TMSCN) to equivalent aldehydes could proceed smoothly with turnover frequency (TOF) up to 3000000 h−1and in near 100% yield under solvent‐free conditions. These organic catalysts also tolerated various aldehydes including aromatic, aliphatic andα,β‐unsaturated aldehydes. This process perfectly conforms to the features of green chemistry: no waste regarding side‐products and unconverted reactants, solvent‐free, excellent catalytic activity, and no requirement for separation.
Enhanced Ionization of Phosphatidylcholines during MALDI Mass Spectrometry Using DCTB as Matrix
Authors: Zhang Ying , Lu Haojie 
Published: September 2012

AbstractPhosphatidylcholines (PCs) are the most abundant phospholipids constituents of the cellular membrane, which exhibit a variety of biological functions. The distinct critical roles in cellular function make their analysis quite demanding. Although MALDI‐MS is one of the most powerful tools for biomolecules identification, it is still limited to phospholipids studies. The ionization of phosphatidylcholines is insufficient, and signals of PCs are frequently confused and suppressed by matrix clusters occurring in the same mass range. As an alternative matrix, T‐2‐(3‐(4‐t‐butyl‐phenyl)‐2‐methyl‐2‐propenylidene) malononitrile (DCTB) was introduced to overcome these problems in our study. Specifically, the signal intensity of phosphatidylcholines from soybean was enhanced more than several ten‐folds using DCTB during positive ion MALDI‐TOFMS. Peak overlaps caused by the wide distributions of series fatty acid residues from phospholipids were separated by introducing cesium cation. The occurred mass shift of 131.90 Da between [M+Cs]+ and [M+H]+ ("M" represents the molecular weight of the corresponding neutral hosphatidylcholine) was approved to be helpful in the assignments of ambiguous peaks of PCs from soybean. For real sample analysis, employing cesium chloride as an auxiliary reagent successfully facilitated the profiling and characterizing of PCs extracted from mouse lung and egg yolk followed by analysis with MALDI‐TOFMS using DCTB as matrix.
Synthesis and Characterization of Comb‐like P(MPEGA‐co‐AM) Copolymer as Phase Change Materials
Authors: Xiang Hengxue , Chen Shaohua , Wang Shichao , Peng Cheng , Zhu Meifang 
Published: September 2012

AbstractComb‐like acrylic acid poly(ethylene glycol) methyl ether ester (MPEGA)‐co‐acrylamide (AM) copolymer [P(MPEGA‐co‐AM)] as novel phase change materials (PCMs) was successfully synthesized via free‐radical water solution polymerization. The structures of P(MPEGA‐co‐AM) was characterized by Fourier Transform Infrared (FT‐IR). The experimental results showed that P(MPEGA‐co‐AM) copolymer possessed high molecular weight (Mn=66 kg/mol), narrow molecular weight distribution (PDI≈1.14). The phase transition temperature of copolymer decreases to 31 °C, which is very much appreciated and urgently needed for smart PCM related to human body. Moreover, P(MPEGA‐co‐AM) had good thermal stability even at 380°C.
Cucurbit[7]uril‐Based Vesicles Formed by Self‐assembly of Supramolecular Amphiphiles
Authors: Li Jiaxi , Zhou Lipeng , Luo Quan , Wang Yongguo , Zhang Chunqiu , Lu Wei , Xu Jiayun , Liu Junqiu 
Published: September 2012

AbstractCucurbituril (CB), a well‐known macrocyclic cavitand, has been used extensively to construct supramolecular aggregates. Based on host‐guest intertactions, an adamantanyl derivative guest molecule was designed and synthesized to prepare a supramolecular amphiphile with cucurbit[7]uril. In aqueous solution, the cucurbit[7]uril based supramolecular amphiphiles self‐assemble into well‐defined vesicles, and their disassembly can be achieved by addition of excess competitive agent 1‐adamantanamine hydrochloride. This vesicle functions as a new nanocapsule to encapsulate molecules within its hollow cavity. Through competitive disassembly of supramolecular amphiphiles, the vesicles behave as a novel drug delivery carrier.
Synthesis, Structure of Zinc Complexes Containing Sulfonylated Binaphtholate Ligands and Their Catalytic Activities towards Ring‐Opening Polymerization of Lactide and ε‐Caprolactone
Authors: Zhou Shuangliu , Jiang Yongyao , Xie Tao , Wu Zhanshuan , Zhou Linmin , Xu Wenjing , Zhang Lijun , Wang Shaowu 
Published: September 2012

AbstractReaction of sulfonylated binaphthol [2‐hydroxy‐2′‐tosyloxy‐1,1‐binaphthyl (1a, Ts‐Binol) or 2‐hydroxy‐2′‐(phenylsulfonyloxy)‐1,1‐binaphthyl (1b, Ps‐Binol)] with 1 equiv. of ZnEt2 afforded zinc complexes [(Ts‐Binol)ZnEt]2 (2a) and [(Ps‐Binol)ZnEt]2 (2b). Further reaction of zinc complexes 2a and 2b with benzyl alcohol (BnOH) gave the zinc benzyloxide [(Ts‐Binol)2Zn2(OBn)2]2 (3a) and [(Ps‐Binol)2Zn2(OBn)2]2 (3b). Alternatively, the zinc benzyloxides 3a and 3b could also be obtained by reaction of compound 1a or 1b with Zn(OBn)2 (in situ reaction of ZnEt2 and BnOH). The complexes were fully characterized by elemental analyses and spectroscopic analyses, and complexes 2a, 2b and 3a were further characterized by single‐crystal X‐ray analyses. The catalytic activities of these zinc complexes towards ring‐opening polymerization of ε‐caprolactone and D,L‐lactide were studied.
Effect of SnO2‐Sb2O5 Interlayer on Electrochemical Performances of a Ti‐Substrate Lead Dioxide Electrode
Authors: Kong Haishen , Huang Weimin , Lin Haibo , Lu Haiyan , Zhang Wenli 
Published: September 2012

AbstractThe Ti/SnO2‐Sb2O5/PbO2 electrode was prepared by electrodeposition method onto Ti substrate with SnO2‐Sb2O5 interlayer. Microstructure information of SnO2‐Sb2O5 interlayer and PbO2 coating was characterized by scanning electron microscopy (SEM), X‐ray diffraction (XRD) and X‐ray photoelectron spectroscopy (XPS). Our study shows that the titanium substrate is completely covered by the SnO2‐Sb2O5 solid solution interlayer and the interlayer combines the Ti substrate closely with the PbO2 coating. The electrochemical performance of the Ti/SnO2‐Sb2O5/PbO2 electrode was studied by cyclic voltammogram (CV), electrochemical impedance spectroscopy (EIS) and accelerated life test. The results show the electrochemical activity, electrical conductivity and stability of Ti‐substrate lead dioxide electrode are increased. The deactivation process of the Ti/SnO2‐Sb2O5/PbO2 electrode was also studied by the EIS. The SnO2‐Sb2O5 interlayer can effectively prevent the growth of a TiO2 insulating layer between the substrate and the PbO2 coating during the lifetime tests, thus maintain high activity of Ti/SnO2‐Sb2O5/PbO2 electrode for 10 times longer than Ti/PbO2 electrode without interlayer.
Dissipative Particle Dynamics Study on Aggregation of MPEG‐PAE‐PLA Block Polymer Micelles Loading Doxorubicine
Authors: Yang Chufen , Sun Yao , Zhang Lijuan 
Published: September 2012

AbstractTo guide the molecular design of the pH‐sensitive triblock amphiphilic polymer MPEG‐PAE‐PLA and the formula design of its doxorubicine (DOX)‐loaded micelles, dissipative particle dynamics (DPD) simulations are employed to investigate the aggregation behaviors of the DOX‐loaded micelles. The simulation results showed that the aggregate morphologies of micelles and DOX distribution are influenced by degree of polymerization of blocks, and the proposed structure of polymer is MPEG44‐PAE3‐PLA4. With different contents of polymer or DOX, different aggregate morphologies of the micelles, like microsphere, spindle/column, reticulation or lamella are observed. To prepare the micro‐spherical DOX‐loaded micelles, the polymer content is proposed as 10%–15%, and the DOX content less than 10%.
Effect of Molecular Weight and Processing Additive on the Performance of Low Bandgap Polymer Solar Cells
Authors: Zhao Xiaoli , Tang Haowei , Yang Dalei , Li Hui , Xu Wentao , Yin Li , Yang Xiaoniu 
Published: September 2012

AbstractIn this work, we synthesized a low bandgap polymer polysilole(‐2,6‐diyl‐alt‐5‐octylthieno[3,4‐c]pyrrole‐4,6‐dione) (PDTSTPD) with different molecular weights (Mn). The devices based on PDTSTPD/PC71BM composite are prepared and the dependence of power conversion efficiency (PCE) of the devices on the Mn of conjugated polymers is addressed. We found the hole mobility of PDTSTPD is dependent on the Mn of the polymer, which should be the main reason contributing to the drastic difference of device performance, i.e. the PCE of the device using 10 kDa polymer is only 0.52%, in contrast to 2.3% for 24 kDa polymer device. This PCE data is then further improved to 5.0% via using 1,8‐diiodoctane as processing additive to achieve an optimized morphology for the photoactive layer with an appropriate length‐scale of phase separation for both exciton dissociation and charge transportation.
Electrodeposition of Prussian Blue Nanoparticles on Electrochemically Reduced Graphene Oxide and Synergistically Electrocatalytic Activity toward Guanine
Authors: Yang Tao , Guan Qian , Ma Suyan , Li Qianhe , Jiao Kui 
Published: September 2012

AbstractIn this paper, a simple and reliable fabrication method about electrochemically reduced graphene oxide (ERGNO)‐prussian blue (PB) nanocomposite was proposed for determination of guanine. Due to its unique structural, physical and chemical properties, ERGNO, which was fabricated on the carbon paste electrode (CPE) beforehand through electrochemical reduction of graphene oxide, was selected as a compatible precursor for next‐step PB electrodeposition. Electrochemical behaviors of the resulted PB/ERGNO/CPE were investigated by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The electrochemical results showed that PB/ERGNO/CPE exhibited good electrochemical performances. The electrocatalytic results of guanine further illustrated that graphene prompted the electrocatalytic ability of PB via the redox shift between PB and prussian yellow (PY) in the potential range from 0.5 to 1.2 V, which has not been widely adopted in the PB based electrochemical sensors. The detection limit of guanine could be calculated to be 1.0×10−8 mol/L. It means this PB/ERGNO/CPE platform is quite sensitive and can be readily applied in biosensor field.
Synthesis of Osmapyridiniums by [4+2] Cycloaddition Reaction between Osmium Alkenylcarbyne and Nitriles
Authors: Liu Bin , Zhao Qianyi , Wang Huijuan , Chen Jinxiang , Cao Xiaoyu , Cao Zexing , Xia Haiping 
Published: September 2012

AbstractA novel [4+2] cycloaddition reaction between osmium alkenylcarbyne complex [OsHCl2{CC(PPh3)CHPh}(PPh3)2]+BF4− (1) and nitriles (acetonitrile and benzonitrile) provided metallapyridiniums [OsCl2{CHC(PPh3)CPhCRNH}(PPh3)2]+BF4− (R=CH3 (2), Ph (3)) and OsCl3{CHC(PPh3)CPhCPhNH}(PPh3) (4). A possible mechanism was proposed. Treatment of 2 with n‐BuLi and NEt3 afforded osmapyridines OsCl2{CHC(PPh3)CPhCCH3N}(PPh3)2 (5) and [OsCl{CHC(PPh3)CPhCCH3N}(C6H5N)(PPh3)2]+BF4− (6). The ligands of osmapyridiniums 2 and 4 were changed, thus providing a series of osmapyridiniums [OsCl(SCN){CHC(PPh3)CPhC(CH3)NH}(PPh3)2]+Cl− (7), OsCl(SCN)2{CHC(PPh3)CPhC(CH3)NH}(PPh3) (8), Os(SCN)3{CHC(PPh3)CPhC(CH3)NH}(PPh3) (9), [OsCl{CHC(PPh3)CPhC(CH3)NH}(CH3CN)(PPh3)2]+(BF4−)2 (10), [OsCl{CHC(PPh3)CPhC(CH3)NH}‐(η2‐1,10‐phenanthroline)(PPh3)]+(BF4−)Cl− (11), [OsCl{CHC(PPh3)CPhC(CH3)NH}(η2‐8‐hydroxyquinoline) (PPh3)]+BF4− (12), and [Os{CHC(PPh3)CPhCPhNH}(CH3CN)3(PPh3)]+(BF4−)3 (13). Most of these products were characterized by NMR spectroscopy, elemental analysis and single crystal X‐ray diffraction.
A Near‐infrared Fluorescent Probe for Selective Simultaneous Detection of Fe2+ and Cl− in Living Cells
Authors: Li Ping , Xiao Haibin , Tang Bo 
Published: September 2012

AbstractA naked‐eyed chromo‐near infrared fluorescent probe for simultaneous detection of Fe2+ and Cl− has been developed, based on photoinduced electron transfer mechanism (PET). The fluorophore is cyanine (Cy‐SO3−) and the Fe2+ receptor is 4′‐(aminomethylphenyl)‐2,2′,6′,2′′‐terpyridine (Tpy). The probe responds linearly and rapidly to [Fe2+] and [Cl−] variations under physiological conditions and exhibits high sensitivity, good photostability, and excellent cell membrane permeability. The real‐time imaging of cellular Fe2+ was achieved successfully in living HL‐7702, HepG2, and RAW264.7 cell lines.