bluuebunny/crossref_metadata_2025_split huggingface dataset:
RDA perceptions among Malaysian catalogers
Authors: Mansor Yushiana , Ramdzan Emilia 
Published: June 2014

Purpose
– This study aims to investigate Malaysian catalogers’ awareness, familiarity and understanding of the new bibliographic content standard, i.e. Resource Description and Access (RDA).

Design/methodology/approach
– The survey method was adopted in this study. Questionnaires were used to gather data from respondents. The study included catalogers from higher education institutions in the area of Klang Valley, Malaysia. Purposive sampling method was used to identify the respondents.

Findings
– The results revealed that, in general, though Malaysian catalogers were aware of the RDA, they were only familiar with the basics of RDA and its related topics. They were mainly aware of topics regarding the overview and development of RDA, and indicated low understanding of other topics, such as Functional Requirements for Bibliographic Records (FRBR), related to RDA. The study found that respondents acknowledged the inadequacy of their basic understanding of RDA. The study also identified the catalogers’ needs and preference for RDA training. Most of the catalogers favored learning more about RDA context topics which include FRBR, Functional Requirements for Authority Data and International Cataloging Principles. They indicated willingness to undergo a two- to three-day intensive workshop to learn more about RDA.

Practical implications
– Like in other countries, catalogers in Malaysia may also encounter problems when implementing the new RDA. Findings of this study would be useful in designing RDA trainings for catalogers.

Originality/value
– No study has been done to investigate Malaysian catalogers’ awareness and understanding of RDA.
The impact of information and communication technology on retail property in Malaysia
Authors: Najib Razali Muhammad , Abdul Rahman Rohana , Mohd Adnan Yasmin , Mohd. Yassin Azlina 
Published: June 2014

Purpose– The purpose of this paper is to examine the impact of using information and communication technology (ICT) on retail property in Malaysia. It also examines what listed property companies perceive in terms of the implications of using ICT in the retail property sector in Malaysia.Design/methodology/approach– Data were collected from sample surveys completed by 79 property companies listed on the Bursa Malaysia (formerly known as the Kuala Lumpur Stock Exchange). An ICT retail impact matrix was then developed to assess the significance of ICT on retail property in Malaysia.Findings– The findings of the study revealed that ICT would have only a minor impact on retail property in Malaysia and that there would still be a need for the traditional means of conducting a retail property business. It also found that the listed property companies were ready to implement ICT applications and that the demand for retail property would still increase in Malaysia in the future.Research limitations/implications– Only 66 percent of listed property companies in Malaysia (the respondents) participated in the study.Originality/value– This paper seeks to look at the impact ICT has on retail property in Malaysia. For this purpose, an ICT retail impact matrix was developed to assess this impact. As such, this study will be used as a benchmark for future ICT studies relating to retail property and the real estate sector in Malaysia.
To what extent does the audit committee curb downward earnings forecast guidance?
Authors: Jennifer Ho Li-Chin , Liu Chao-Shin , Frank Wang Xu 
Published: June 2014

Purpose
– The purpose of this paper is to examine the association between audit committee characteristics and a firm’s ability to guide analysts’ forecasts downward to meet or beat earnings benchmarks.

Design/methodology/approach
– The authors expect that a more effective audit committee would be able to reduce managers’ propensity to use downward forecast guidance to avoid negative earnings surprises. Four committee characteristics are used to measure its effectiveness: independence, diligence, expertise and size.

Findings
– For the pre-SOX (Sarbanes-Oxley Act) period (1996-2002), none of the four audit committee characteristics are significantly associated with managers’ propensity to use downward forecast guidance to avoid negative earnings surprises. For the post-SOX era (2003-2004), however, the likelihood of engaging in downward forecast guidance is significantly lower for firms with larger and more independent audit committees. In addition, the likelihood is significantly lower for audit committees that are more diligent and have a higher proportion of the committee members with accounting or finance-related expertise.

Research limitations/implications
– Overall, the authors results suggest that, in response to the increased regulatory and listing requirements in the post-SOX era, audit committees have played a more active role in scrutinizing earnings guidance. Our results also suggest that a more effective audit committee in the post-SOX era curbs managers’ tendency to use downward forecast guidance to meet or beat quarterly earnings targets.

Originality/value
– To the authors knowledge, this study is one of the first to examine the role of the audit committee in reviewing managerial earnings guidance. As earnings guidance plays an important role in the overall financial reporting process over time and given the increasing importance of downward forecast guidance in earnings surprise games in recent years, the authors believe this study addresses an important question and adds to prior literature. Also, this study contributes to their understanding of the changing nature and scope of audit committee oversight activities since the passage of SOX.
Polyadenylation of Friend murine leukemia virus env‐mRNA is affected by its splicing
Authors: Machinaga Akihito , Takase‐Yoden Sayaka 
Published: June 2014

AbstractAs splicing was previously found to be important for increasing Friend murine leukemia virus env‐mRNA stability and translation, we investigated whether splicing of env‐mRNA affected the poly(A) tail length using env expression vectors that yielded unspliced or spliced env‐mRNA. Incomplete polyadenylation was detected in a fraction of the unspliced env‐mRNA products in an env gene‐dependent manner, showing that splicing of Friend murine leukemia virus plays an important role in the efficiency of complete polyadenylation of env‐mRNA. These results suggested that the promotion of complete polyadenylation of env‐mRNA by splicing might partially explain up‐regulation of Env protein expression as a result of splicing.
Optimizing methyl‐eugenol aromatherapy to maximize posttreatment effects to enhance mating competitiveness of male Bactrocera carambolae (Diptera: Tephritidae)
Authors: Haq Ihsan ul , Vreysen Marc J.B. , Cacéres Carlos , Shelly Todd E. , Hendrichs Jorge 
Published: June 2014

AbstractMethyl‐eugenol (ME) (1,2‐dimethoxy‐4‐(2‐propenyl)benzene), a natural phytochemical, did enhance male Bactrocera carambolae Drew & Hancock (Diptera: Tephritidae) mating competitiveness 3 d after ingestion. Enhanced male mating competitiveness can significantly increase the effectiveness of the sterile insect technique (SIT). ME application to mass reared sterile flies by feeding is infeasible. ME application by aromatherapy however, would be a very practical way of ME application in fly emergence and release facilities. This approach was shown to enhance mating competitiveness of B. carambolae 3 d posttreatment (DPT). Despite this added benefit, every additional day of delaying release will reduce sterile fly quality and will add cost to SIT application. The present study was planned to assess the effects of ME‐aromatherapy on male B. carambolae mating competitiveness 1DPT and 2DPT. ME aromatherapy 1DPT or 2DPT did enhance mating competitiveness of B. carambolae males whereas ME feeding 1DPT and 2DPT did not. Male mating competitiveness was enhanced by the ME aromatherapy irrespective if they received 1DPT, 2DPT or 3DPT. ME aromatherapy, being a viable approach for its application, did enhance mating competitiveness of male B. carambolae 1 d posttreatment as ME feeding did 3 d after ingestion.
Women, Enlightenment and the Literary Fairy Tale in English
Authors: Douglas Aileen 
Published: June 2014

AbstractIn eighteenth‐century England the literary fairy tale was known mainly through translation from the French, especially of the works of Marie‐Catherine, Comtesse d'Aulnoy. There were, however, several indigenous efforts at the form, including the two fairy tales in Sarah Fielding's The Governess (1749) and The Fairy‐Ring, or Emeline (1783), by Elizabeth Sheridan. Particularly identified with the female reader, the literary fairy tale was also hospitable to women writers. Appealing to the imagination through their fantastic and marvellous elements, the fairy tales of Fielding and Sheridan are also concerned with the exertions of female reason and the foundations of female autonomy.
Interleukin‐6 deletion in mice driven by aP2‐Cre‐ERT2 prevents against high‐fat diet‐induced gain weight and adiposity in female mice
Authors: Navia B. , Ferrer B. , Giralt M. , Comes G. , Carrasco J. , Molinero A. , Quintana A. , Leclerc J. , Viollet B. , Señarís R. M. , Hidalgo J. 
Published: June 2014

AbstractAimInterleukin‐6 (IL‐6) is a major cytokine controlling body weight and metabolism, but because many types of cells can synthesize and respond to IL‐6 considerable uncertainty still exists about the mechanisms underlying IL‐6 effects. Therefore, the aim of this study was to analyse the effects of tissue‐specific deletion of IL‐6 using a fatty acid binding protein (aP2) promoter‐Cre inducible system (aP2‐Cre‐ERT2).MethodsTissue‐specific IL‐6 KO mice (aP2‐IL‐6 KO mice) were produced upon tamoxifen administration and were fed a high‐fat diet (HFD, 58.4% kcal from fat) or a control diet (18%) for 14 weeks.ResultsaP2‐IL‐6 KO female mice on a HFD gained less weight and adiposity than littermate wild‐type mice, but these effects were not observed in males. Hypothalamic factors such as NPY and AgRP showed a pattern of expression consistent with this sex‐specific phenotype. PGC‐1α expression was increased in several tissues in aP2‐IL‐6 KO female mice, which is compatible with increased energy expenditure. Serum leptin, insulin, glucose, cholesterol and triglycerides levels were increased by HFD, and in females IL‐6 deficiency reversed this effect in the case of insulin and cholesterol. HFD induced impaired responses to insulin and glucose tolerance tests, but no significant differences between genotypes were observed.ConclusionThe present results demonstrate that deletion of IL‐6 driven by aP2‐Cre regulates body weight, body fat and metabolism in a sex‐specific fashion.
Metabolic syndrome‐like components and prostate cancer risk: results from the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study
Authors: Sourbeer Katharine N. , Howard Lauren E. , Andriole Gerald L. , Moreira Daniel M. , Castro‐Santamaria Ramiro , Freedland Stephen J. , Vidal Adriana C. 
Published: June 2014

ObjectiveTo evaluate the relationship between number of metabolic syndrome (MetS)‐like components and prostate cancer diagnosis in a group of men where nearly all biopsies were taken independent of prostate‐specific antigen (PSA) level, thus minimising any confounding from how the various MetS‐like components may influence PSA levels.Subjects/Patients and MethodsWe analysed data from 6426 men in the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study with at least one on‐study biopsy. REDUCE compared dutasteride vs placebo on prostate cancer risk among men with an elevated PSA level and negative pre‐study biopsy and included two on‐study biopsies regardless of PSA level at 2 and 4 years. Available data for MetS‐like components included data on diabetes, hypertension, hypercholesterolaemia, and body mass index. The association between number of these MetS‐like components and prostate cancer risk and low‐grade (Gleason sum <7) or high‐grade (Gleason sum >7) vs no prostate cancer was evaluated using logistic regression.ResultsIn all, 2171 men (34%) had one MetS‐like component, 724 (11%) had two, and 163 (3%) had three or four. Men with more MetS‐like components had lower PSA levels (P = 0.029). One vs no MetS‐like components was protective for overall prostate cancer (P = 0.041) and low‐grade prostate cancer (P = 0.010). Two (P = 0.69) or three to four (P = 0.15) MetS‐like components were not significantly related to prostate cancer. While one MetS‐like component was unrelated to high‐grade prostate cancer (P = 0.97), two (P = 0.059) or three to four MetS‐like components (P = 0.02) were associated with increased high‐grade prostate cancer risk, although only the latter was significant.ConclusionWhen biopsies are largely PSA level independent, men with an initial elevated PSA level and a previous negative biopsy, and multiple MetS‐like components were at an increased risk of high‐grade prostate cancer, suggesting the link between MetS‐like components and high‐grade prostate cancer is unrelated to a lowered PSA level.
Drug Repurposing Based on Drug–Drug Interaction
Authors: Zhou Bin , Wang Rong , Wu Ping , Kong De‐Xin 
Published: June 2014

Given the high risk and lengthy procedure of traditional drug development, drug repurposing is gaining more and more attention. Although many types of drug information have been used to repurpose drugs, drug–drug interaction data, which imply possible physiological effects or targets of drugs, remain unexploited. In this work, similarity of drug interaction was employed to infer similarity of the physiological effects or targets for the drugs. We collected 10 835 drug–drug interactions concerning 1074 drugs, and for 700 of them, drug similarity scores based on drug interaction profiles were computed and rendered using a drug association network with 589 nodes (drugs) and 2375 edges (drug similarity scores). The 589 drugs were clustered into 98 groups with Markov Clustering Algorithm, most of which were significantly correlated with certain drug functions. This indicates that the network can be used to infer the physiological effects of drugs. Furthermore, we evaluated the ability of this drug association network to predict drug targets. The results show that the method is effective for 317 of 561 drugs that have known targets. Comparison of this method with the structure‐based approach shows that they are complementary. In summary, this study demonstrates the feasibility of drug repurposing based on drug–drug interaction data.
Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories – indications for novel treatments of addiction
Authors: Everitt Barry J. 
Published: June 2014

AbstractThis review discusses the evidence for the hypothesis that the development of drug addiction can be understood in terms of interactions between Pavlovian and instrumental learning and memory mechanisms in the brain that underlie the seeking and taking of drugs. It is argued that these behaviours initially are goal‐directed, but increasingly become elicited as stimulus–response habits by drug‐associated conditioned stimuli that are established by Pavlovian conditioning. It is further argued that compulsive drug use emerges as the result of a loss of prefrontal cortical inhibitory control over drug seeking habits. Data are reviewed that indicate these transitions from use to abuse to addiction depend upon shifts from ventral to dorsal striatal control over behaviour, mediated in part by serial connectivity between the striatum and midbrain dopamine systems. Only some individuals lose control over their drug use, and the importance of behavioural impulsivity as a vulnerability trait predicting stimulant abuse and addiction in animals and humans, together with consideration of an emerging neuroendophenotype for addiction are discussed. Finally, the potential for developing treatments for addiction is considered in light of the neuropsychological advances that are reviewed, including the possibility of targeting drug memory reconsolidation and extinction to reduce Pavlovian influences on drug seeking as a means of promoting abstinence and preventing relapse.
Performance of compulsive behavior in rats is not a unitary phenomenon – validation of separate functional components in compulsive checking behavior
Authors: Tucci Mark C. , Dvorkin‐Gheva Anna , Johnson Eric , Cheon Paul , Taji Leena , Agarwal Arnav , Foster Jane , Szechtman Henry 
Published: June 2014

AbstractA previous analysis of the quinpirole sensitisation rat model of obsessive‐compulsive disorder revealed that the behavioral phenotype of compulsive checking consists of three constitutive components – vigor of checking performance, focus on the task of checking, and satiety following a bout of checking. As confirmation of this analysis, the aim of the present study was to reconstitute, without quinpirole treatment, each of the putative components, with the expectation that these would self‐assemble into compulsive checking. To reconstitute vigor and satiety, the employed treatment was a bilateral lesion of the nucleus accumbens core (NAc), as this treatment was shown previously to exaggerate these components. To reconstitute focus, the employed treatment was a low dose of the serotonin‐1A receptor agonist 8‐hydroxy‐2‐(di‐n‐propylamino) tetralin hydrochloride (DPAT) (0.0625 mg/kg), as high doses of this drug induce compulsive behavior and exacerbate focus. Results showed that injection of DPAT to NAc lesion rats did yield compulsive checking. Neither the drug alone nor the NAc lesion by itself produced compulsive checking. The demonstrated synthesis of compulsive checking by the combined treatment of low‐dose DPAT and NAc lesion strengthened the previous fractionation of the model obsessive‐compulsive disorder phenotype into three constitutive components, and suggested a role for serotonin‐1A receptors outside the NAc in enhanced focus on the task of checking.
Hyperactive antifreeze protein from an Antarctic sea ice bacterium Colwellia sp. has a compound ice‐binding site without repetitive sequences
Authors: Hanada Yuichi , Nishimiya Yoshiyuki , Miura Ai , Tsuda Sakae , Kondo Hidemasa 
Published: June 2014

Antifreeze proteins (AFPs) are structurally diverse macromolecules that bind to ice crystals and inhibit their growth to protect the organism from injuries caused by freezing. An AFP identified from the Antarctic bacterium Colwellia sp. strain SLW05 (ColAFP) is homologous to AFPs from a wide variety of psychrophilic microorganisms. To understand the antifreeze function of ColAFP, we have characterized its antifreeze activity and determined the crystal structure of this protein. The recombinant ColAFP exhibited thermal hysteresis activity of approximately 4 °C at a concentration of 0.14 mm, and induced rapid growth of ice crystals in the hexagonal direction. Fluorescence‐based ice plane affinity analysis showed that ColAFP binds to multiple planes of ice, including the basal plane. These observations show that ColAFP is a hyperactive AFP. The crystal structure of ColAFP determined at 1.6 Å resolution revealed an irregular β‐helical structure, similar to known homologs. Mutational and molecular docking studies showed that ColAFP binds to ice through a compound ice‐binding site (IBS) located at a flat surface of the β‐helix and the adjoining loop region. The IBS of ColAFP lacks the repetitive sequences that are characteristic of hyperactive AFPs. These results suggest that ColAFP exerts antifreeze activity through a compound IBS that differs from the characteristic IBSs shared by other hyperactive AFPs. This study demonstrates a novel method for protection from freezing by AFPs in psychrophilic microorganisms.DatabaseStructural data for ColAFP have been submitted to the Protein Data Bank (PDB) under accession number 3WP9.
Decoupling Streamflow Responses to Climate Variability and Land Use/Cover Changes in a Watershed in Northern China
Authors: Guo Junting , Zhang Zhiqiang , Zhou Jie , Wang Shengping , Strauss Peter 
Published: June 2014

AbstractRestored annual streamflow (Qr) and measured daily streamflow of the Chaohe watershed located in northern China and associated long‐term climate and land use/cover data were used to explore the effects of land use/cover change and climate variability on the streamflow during 1961‐2009. There were no significant changes in annual precipitation (P) and potential evapotranspiration, whereas Qr decreased significantly by 0.81 mm/yr (p < 0.001) over the study period with a change point in 1999. We used 1961‐1998 as the baseline period (BP) and 1999‐2009 the change period (CP). The mean Qr during the CP decreased by 39.4 mm compared with that in the BP. From 1979 to 2009, the grassland area declined by 69.6%, and the forest and shrublands increased by 105.4 and 73.1%, respectively. The land use/cover change and climate variability contributed for 58.4 and 41.6% reduction in mean annual Qr, respectively. Compared with the BP, median and high flows in the CP decreased by 38.8 and up to 75.5%, respectively. The study concludes that large‐scale ecological restoration and watershed management in northern China has greatly decreased water yield and reduced high flows due to the improved land cover by afforestation leading to higher water loss through evapotranspiration. At a large watershed scale, land use/cover change could play as much of an important role as climate variability on water resources.