bluuebunny/crossref_metadata_2025_split huggingface dataset:
PEMBUATAN MEDIA PENGECAP DAUN PADA KERTAS TK B SANTA MARIA
Authors: Sudarto Sudarto , Fransiska Fransiska , Sarayati Sarayati 
Published: August 2024

Tujuan dari kegiatan Pengabdian kepada Masyarakat (PkM) ini adalah untuk memberikan pengetahuan dan pemahaman melalui aktivitas pembuatan media pengecap daun pada siswa/siswi TK Santa Maria DAK Jaya dalam pengenalan media daun sebagai media pembelajaran. Kegiatan Pembuatan media ini dilakukan di taman kanak-kanak karena kegiatan ini akan menuju pada praktek secara langsung tentang aktivitas pembuatan media ini dapat meransang aspek perkembangan anak yaitu aspek kognitif, motorik halus, dan sosial emosional. Metode yang digunakan dalam kegiatan pengabdian ini adalah metode pelatihan. Pelatihan dilaksanakan melalui kolaborasi antara tim pengabdian, siswa/siswi, dan guru TK Santa Maria Dak Jaya Kecamatan Binjai Hulu. Dalam pelaksanaannya, program ini melalui 3 tahap kegiatan yaitu tahap perencanaan, tahap pelaksanaan dan tahap evaluasi. Hasil dari kegiatan PkM ini adalah para siswa terlihat antusias dapat melaksanakan kegiatan pembuatan media dan mereka dapat melakukan semua tahapan kegiatan dengan baik mulai dari pengenalan tentang daun, pengenalan warna, serta cara membuat media pengecap, kegiatan mencuci tangan serta evaluasi dari kegiatan membuat media.
Fabrication of injectable alginate hydrogels with sustained release of 4-octyl itaconate for articular anti-inflammatory
Authors: Bao Ronghua , Mao Yifan , Zhang Yuliang , Chai Junlei , Zhang Yuanbin , Luo Cheng , Zhang Kailong , Jiang Guohua , He Xiaodan 
Published: August 2024

BACKGROUND: Osteoarthritis (OA) is a chronic and degenerative joint disease that remains a great challenge in treatment due to the lack of effective therapies. 4-octyl itaconate (4-OI) is a novel and potent modulator of inflammation for the treatment of inflammatory disease. However, the clinical usage of 4-OI is limited due to its poor solubility and low bioavailability. As a promising drug delivery strategy, injectable hydrogels offers an effective approach to address these limitations of 4-OI. OBJECTIVE: The aim of the study was to verify that the composite 4-OI/SA hydrogels could achieve a controlled release of 4-OI and reduce damage to articular cartilage in the group of osteoarthritic rats treated with the system. METHODS: In this study, an injectable composite hydrogel containing sodium alginate (SA) and 4-octyl itaconate (4-OI) has been developed for continuous intra-articular administration in the treatment of OA. RESULTS: After intra-articular injection in arthritic rats, the as-prepared 4-OI/SA hydrogel containing of 62.5 μM 4-OI effectively significantly reduced the expression of TNF-α, IL-1β, IL-6 and MMP3 in the ankle fluid. Most importantly, the as-prepared 4-OI/SA hydrogel system restored the morphological parameters of the ankle joints close to normal. CONCLUSION: 4-OI/SA hydrogel shows a good anti-inflammatory activity and reverse cartilage disruption, which provide a new strategy for the clinical treatment of OA.
Discrete variational method for partial differential equations of functionally gradient beam vibration
Authors: Yu Jianxi 
Published: August 2024

The field of engineering is becoming increasingly complex. In order to adapt to the numerical simulation of solving the partial differential equation of functionally graded beam vibration, a higher order stable numerical algorithm has been constructed. Differential quadrature method is used in discrete space domain. The discrete variational method is constructed in the time domain. The index differential Algebraic equation are obtained by combining the two methods. The discrete variational scheme is constructed for simulation. The results indicate that under long-term simulation, both the velocity and displacement constraints of the Runge Kutta method have defaulted. Displacement constraint values differ by 5 × 10 - 10. The velocity, displacement and acceleration constraints of the discrete variational method are stable. Compared with the Runge Kutta method, the constraint magnitude is reduced. The speed constraint is maintained at within 2.5 × 10 - 15. The displacement constraint level is maintained at within 1 × 10 - 16. This indicates that the discrete variational method has high accuracy and good stability when solving problems such as the vibration equation of functionally graded beams. When the step sizes are h= 0.1 m and h= 0.01 m, the accuracy of the discrete variational method is close. The larger the step size h, the higher the computational efficiency of the discrete variational method. The discrete variational method can maintain structural and energy conservation, making it suitable for long-term simulations. This has a good effect on solving complex problems in the field of partial differential equations.
Individuals and Families Affected by RYR1-Related Diseases: The Patient/Caregiver Perspective
Authors: van de Camp Sanne A.J.H. , Stinissen Lizan , Huseth Andrew , Simon Brentney , Ryan Jennifer , Sarkozy Anna , Van Petegem Filip , Goldberg Michael F. , Jungbluth Heinz , Böhm Johann , Oortwijn Wija , Dirksen Robert T. , Voermans Nicol C. 
Published: August 2024

Background and objective: Pathogenic variants of RYR1, the gene encoding the principal sarcoplasmic reticulum calcium release channel (RyR1) with a crucial role in excitation-contraction coupling, are among the most common genetic causes of non-dystrophic neuromuscular disorders. We recently conducted a questionnaire study focusing on functional impairments, fatigue, and quality of life (QoL) in patients with RYR1-related diseases ( RYR1-RD) throughout the recognized disease spectrum. In this previous questionnaire study the medical perspective was taken, reflective of a study protocol designed by neurologists and psychologists. With this present study we wanted to specifically address the patient perspective. Methods: Together with affected individuals, family members, and advocates concerned with RYR1-RD, we developed an online patient survey that was completed by 227 patients or their parents/other caretakers (143 females and 84 males, 0–85 years). We invited 12 individuals, representing most of the patient group based on age, sex, race, and type and severity of diagnosis, to share their personal experiences on living with a RYR1-RD during an international workshop in July 2022. Data were analyzed through a mixed-methods approach, employing both a quantitative analysis of the survey results and a qualitative analysis of the testimonials. Results: Data obtained from the combined quantitative and qualitative analyses provide important insights on six topics: 1) Diagnosis; 2) Symptoms and impact of the condition; 3) Physical activity; 4) Treatment; 5) Clinical research and studies; and 6) Expectations. Conclusions: Together, this study provides a unique patient perspective on the RYR1-RD spectrum, associated disease impact, suitable physical activities and expectations of future treatments and trials, and thus, offers an essential contribution to future research.
PENERAPAN REGENERATIVE DESIGN DALAM UPAYA MENGEMBALIKAN KERUSAKAN PADA LINGKUNGAN
Authors: Ghifari M. Nu’man Al , Mutia Fairuz 
Published: August 2024

Indonesia merupakan negara berkembang yang mana pembangunan infrastruktur terus meningkat dalam kurun waktu lima tahun terakhir. Pembangunan infrastruktur secara masif dan menyebar keseluruh wilayah Indonesia ini digagas guna memastikan terjaminya ketersediaan infrastruktur agar dapat menjadi lompatan bagi Indonesia untuk menjadi negara maju. Permasalahan pembangunan yang sering diangkat menurut beberapa pengamat lingkungan hidup adalah banyaknya pembangunan di Indonesia yang mengabaikan masalah dampak sosial dan lingkungan. Seperti halnya yang disampaikan salah satu pengamat tata kota, Darmaningtyas yang menilai pembangunan Megaproyek Kereta Cepat Jakarta-Bandung dapat merusak lingkungan karena resapan air jadi berkurang dan lumbung pangan juga berkurang.
Oleh karena itu dibutuhkan suatu konsep desain dalam pembangunan yang bisa mengembalikan kerusakan dan memiliki dampak positif terhadap kelestarian lingkungan. Tujuan penelitian ini adalah untuk mengetahui peranan konsep regenerative design dalam upaya mengembalikan kerusakan lingkungan dan memiliki dampak positif terhadap lingkungan. Metode deskriptif dan eksploratif digunakan dalam penelitian untuk memberikan penjelasan mengenai konsep atau pola yang digunakan dalam regenerative design dalam merespon permasalahan kelestarian lingkungan.
Dari hasil analisis didapatkan bahwa konsep regenerative design bisa membawa pembangunan menjadi sebuah proses untuk menjadi bagian dari ekosistem dan juga meningkatkan kualitasnya. Dengan demikian konsep tersebut bisa meminimalisir dampak lingkungan serta bisa menciptakan lingkungan atau merevitalisasi lingkungan yang telah rusak.
ANALISA POLA SPASIAL TERMINAL PENUMPANG GAPURA SURYA NUSANTARA PELABUHAN TANJUNG PERAK SURABAYA
Authors: Andini Dewanti Surya , Soedjarwo Mohammad Pranoto 
Published: August 2024

Terminal Penumpang Gapura Surya Nusantara di kawasan Pelabuhan Tanjung Perak Surabaya adalah kawasan industri, perdagangan serta jasa, berupa terminal cargo dan terminal penumpang. Tujuan penelitian ini, menganalisa keadaan bangunan meliputi hubungan pola sirkulasi dan ruang. Bangunan ini terdiri dari tiga lantai, lantai satu dan dua menggunakan pola sirkulasi radial yang sesuai dengan fungsi kegiatan alur pelayaran. Sementara pada lantai tiga menggunakan pola sirkulasi linear yang dapat menunjang kegiatan area komersil. Penataan ruang saat ini dapat menunjang kegiatan pelayaran domestik, tetapi tidak dapat menunjang kegiatan pelayaran internasional. Bangunan ini tidak dapat melayani pelayaran internasional karena ada beberapa ruang penunjang yang belum ada. Walaupun begitu pengelola bangunan berusaha meningkatkan pelayanan yang nyaman bagi pengguna bangunan. Hasil analisa pola spasial tata guna lahan dan ruang ini diharapkan meningkatkan kualitas menjadi pedoman bagi terminal penumpang pelabuhan lain di Indonesia agar pola tata guna lahan dan pola ruang sesuai dengan standar yang ditetapkan.
KAJIAN PENDEKATAN ARSITEKTUR KOLONIAL DALAM KONTEKS LOKALISM PADA BANGUNAN MUSEUM PENDIDIKAN DI SURABAYA
Authors: ALFATAH MOCHAMAD HARITS ADAM , Elviana Eva 
Published: August 2024

Di daerah Jawa Timur sendiri memiliki museum yang cukup banyak di Kota Surabaya yang memiliki. Dengan perkembangan zaman, bangunan museum di Jawa Timur termasuk Kota Surabaya sangatlah maju, di setiap daerah Kota Surabaya yang terdapat bagunan museum sedikit demi sedikit mulai di benahi. Bangunan museum di kota Surabaya sendiri memang sudah melakukan pembenahan dan perawatan agar masyarakat dapat nyaman dan sangat senang saat berkunjung ke museum tersebut tetapi dengan adanya fasilitas edukasi, pameran juga untuk masyarakat yang berkunjung di dalam bangunan museum tersebut, tak lupa juga dari segi fasad maupun langgam dan fasilitas hiburan dan rekreasi juga harus disediakan dalam bangunan museum di kota Surabaya untuk menambahkan kegiatan pada tempat tersebut. Dalam hal ini penelitui menggunakan subjek bangunan museum Pendidikan di Surabaya dan juga menggunakan objek pendekatan arsitektur kolonial. Penelitian bangunan museum ini bertujuan untuk mengembangkan ketertarikan pada masyarakat terhadap bangunan museum. Hasil penelitian ini yaitu diharapkan dapat menjadi wadah edukasi dan wisata agar lebih mengetahui sejarah local dengan kemauan diri sendiri.
PENERAPAN TRASIT-ORIENTED DEVELOPMENT DALAM MEWUJUDKAN TRANSPORTASI BERKELANJUTAN PADA KAWASAN JEMBATAN SURAMADU
Authors: Hidayat Rachmad , Zuhri Syaifuddin 
Published: August 2024

Kabupaten Bangkalan menjadi pintu gerbang utama dalam berbagai kegiatan yang menghubungkan Jawa dan Madura. Masuknya Kabupaten Bangkalan dalam rencana pengembangan wilayah Gerbangkertosusilo menjadi konsentrasi Pemerintah dalam pembangunan infrastruktur. Transportasi yang terdapat di Kabupaten Bangkalan saat ini hanya mengandalkan jaringan jalan raya yang terhubung dari Jembatan Suramadu. Berdasarkan data BPWS,2017 menyebutkan bahwa akan membangun dan mengelola wilayah kaki Jembatan Suramadu sebagai pintu gerbang dalam pengembangan simpul-simpul penghubung transportasi utama dengan menetapkan luasan ±600 Ha. Dengan adanya layanan transportasi yang menyeluruh kepada masyarakat maka Transit Oriented Development menjadi sebuah jawaban untuk layanan moda transportasi yang teringrasi dengan layanan mode lain. Penelitian ini dapat menjadi dasar pertimbangan dalam mengarahkan kebijakan agar dapat terlaksana secara tepat pengembangan kawasan di sekitar transit berbasis Transit Oriented Development sehingga dapat mendorong pengguna moda transportasi dalam terwujudnya keberlanjutan transportasi di Kabupaten Bangkalan.
KAJIAN KONSEP ARSITEKTUR KONTEMPORER PADA EXTERIOR BANGUNAN BOGOR CREATIVE CENTER
Authors: Zidan Ahmad Ikhbar , Utomo He 
Published: August 2024

Indonesia merupakan negara dengan tingkat pertumbuhan ekonomi yang relatif cepat, Pemerintah memusatkan pembangunan ekonomi Indonesia dengan memperkuat basis ekonomi. Salah satu industri yang sangat layak mendapat prioritas yaitu ekonomi kreatif. Pemerintah Daerah Jawa Barat melihat potensi Kota Bogor dengan memusatkan industri kreatif. Bogor Creative Center dibangun di bawah program strategis Pemerintah Provinsi Jawa Barat untuk menciptakan wadah bagi para pelaku kreatif untuk meningkatkan Industri Kreatif 4.0 di Kota Hujan. Bogor Creative Center dibangun dengan hati-hati tanpa merusak warisan budaya di sekitarnya. Desain Bogor Creative Center lebih dari sekedar bangunan, melainkan merepresentasikan ruang terbuka hijau yang cukup luas. Metode penelitian ini menggunakan teknik deskriptif kualitatif, yaitu hubungan antara subjek penelitian dengan tujuh konsep dasar arsitektur kontemporer. Hasil penelitian ini menunjukkan bahwa penerapan konsep dasar yang belum maksimal diterapkan pada exterior Bogor Creative Center yaitu bangunan kokoh, memiliki fasad yang transparan, eksplorasi elemen lansekap. Sedangkan konsep dasar yang telah diterapkan gubahan ekspresif dan dinamis, harmonisasi ruang luar dan ruang dalam, konsep ruang terkesan terbuka, kenyamanan hakiki.
Analysis of the correlation between cervical HPV infection, cervical lesions and vaginal microecology
Authors: Fan Zhongru , Han Dongyu , Fan Xin , Zeng Yu , Zhao Lin 
Published: August 2024

BackgroundVaginal microbiota is involved in human papillomavirus (HPV) infection and cervical cancer (CC) progression, and the specific changes in vaginal microbial composition during this process remains uncertain.ObjectiveThis study aimed to observe the changes in the specific composition of vaginal microorganisms in different cervical lesions and identify biomarkers at different stages of lesions.MethodsIn this study we used the illumina high-throughput gene sequencing technology to determine the V4 region of 16SrRNA and observed the vaginal microbial composition in different cervical lesions.ResultsThe vaginal microbiota of patients with high-risk HPV infection and cervical lesions is significantly different from that of the normal population, but there is no significant difference in the richness of vaginal microbes. The diversity of vaginal species in CC patients is higher than that in high-risk HPV infection or CIN patients. The main manifestation is an increase in the diversity of vaginal microbes, a decrease in the relative abundance of cyanobacteria and Lactobacillus, and an increase in the relative abundance of dialister, peptonephila and other miscellaneous bacteria. There are characteristic vaginal biomarker in normal women, high risk HPV patients and CC patients. In detail, the biomarker in the normal group was varibaculum, the biomarker in the high-risk HPV group was saccharopolyspora, the biomarker of the CC group was the Proteobacteria, Corynebacterium, Coprococcus, Peptococcus and Ruminococcus.ConclusionsThe study indicated that the compositions of vaginal microbes in different cervical lesions is different. The vaginal microbial composition has a certain diagnostic effect on healthy women, patients with high-risk HPV infection and cervical lesions. These microbes may serve as potential biomarkers for CC. It also provided an effective way for the treatment of HPV infections and cervical lesions.
Scale to measure student perception in collaborative online international learning experiences: design and validation
Authors: Rozo-García Hugo , Alcantar-Nieblas Carolina , Ramírez-Montoya María Soledad 
Published: August 2024

IntroductionDigital education is favorably positioned as a learning option; it employs various strategies, pedagogies, and methodologies, including collaborative online international learning experiences (COIL). This alternative, inherent to the digital era, transcends traditional educational methods by boosting technology to enhance learning experiences. Its given purpose is to improve learning gains, foster interculturality, internationalizing the curriculum, and strengthening skills necessary for the 21st century. Moreover, it can potentially address global educational needs that have not been fulfilled in the past.MethodsThis study conducted a content validation of a scale (instrument) intending to measure students' perception of collaborative online international learning experiences (COIL) in three dimensions: (a) interaction among students in digital environments, (b) collaborative work in multicultural teams to achieve goals, and (c) peer reflection on differences and similarities during collaboration. The study employed the Delphi method of expert judgment.ResultsIn the overall scale, Aiken's V values indicated that the clarity criterion did not attain an acceptable score. Therefore, a review is desired to determine which instrument items need reformulation. However, Aiken's V scores met acceptable coherence, relevance, and sufficiency values.ConclusionThe proposed scale contributes to research on collaborative online international learning experiences, serving as a valuable tool for future investigations, particularly those focused on measurement, and as a reference for evaluating COIL experiences among students.
Non-linear relationship between TyG index and the risk of prediabetes in young people: a 5-year retrospective cohort study in Chinese young adults
Authors: Xiao Jianhui , Zhou Li , Luo Cheng , Han Yong , Huang Zhenhua 
Published: August 2024

ObjectiveGiven the limited evidence on the relationship between the triglyceride-glucose (TyG) index and the risk of prediabetes among young adults, our study aimed to investigate the potential impact of the TyG index on the future development of prediabetes in young individuals.MethodsThis retrospective cohort study included 125,327 healthy adults aged 20 to 45 years. We utilized Cox proportional hazards regression models, combined with cubic spline functions and smooth curve fitting, to assess the relationship between baseline TyG index and the risk of prediabetes among young adults, exploring its non-linear association. A series of sensitivity analyses and subgroup analyses were conducted to ensure the robustness of our findings.ResultsAfter adjusting for covariates, the study found a positive correlation between the TyG index and the risk of prediabetes (HR=1.81, 95%CI: 1.54–2.13, p&lt;0.0001). The risk of prediabetes increased progressively across quartiles of the TyG index (Q1 to Q4), with Q4 showing a significantly higher risk compared to Q1 (adjusted HR=2.33, 95% CI=1.72–3.16). Moreover, a non-linear relationship was identified between the TyG index and the risk of prediabetes, with an inflection point at 9.39. To the left of the inflection point, the HR was 2.04 (95% CI: 1.69 to 2.46), while to the right, the HR was 0.89 (95% CI: 0.48 to 1.65).ConclusionOur study reveals a non-linear relationship and a saturation effect between the TyG index and the development of prediabetes among young individuals in China, with an inflection point at 9.39. Understanding this non-linear relationship can assist clinicians in identifying young individuals at high risk and implementing targeted interventions to reduce their risk of progressing to diabetes.
Evaluation of the risk of hypothyroidism and its clinical manifestations using the Zulewski scale
Authors: Ferreira-Hermosillo Aldo , Toledo Juan Omar , Cordoba Karla 
Published: August 2024

BackgroundGlobally, clinical hypothyroidism affects an estimated 0.5 to 5% of the population, while subclinical hypothyroidism affects 5-20%. Limited data is available on the prevalence of thyroid disease within the Mexican population. The objective of this study was to describe the characteristics of people screened for hypothyroidism in Mexico during 2022 using the Zulewski scale.MethodsA cross-sectional analysis was conducted using data obtained from a digital survey administered by an e-Health platform. This study included participants of all genders, aged 18 years and older (n = 31,449). Descriptive statistics (frequencies and percentages) were sued to describe the data. Differences between groups were assessed through the chi-square or Fischer’s exact test. Information gathered was subjected to hierarchical segmentation analysis to explore trends and patterns. Statistical significance was set as &lt;0.05.ResultsAmong the participants, 87.7% were women, and 80% fell within the age group 18 and 44 years. According to the Zulewski scale, 27% of the participants had a low risk of hypothyroidism, 37.4% were classified as having an intermediate risk, and 35.6% were at a high risk. In people at high risk of hypothyroidism, the most common symptom was constipation (29.2%) whereas the most common sign was decreased speed of movement (26.2%). Inquiry of slow movements, dry skin, and facial edema allowed the identification of 90.2% of participants at high risk of hypothyroidism.ConclusionsIn Mexico, a significant portion of the population is at an intermediate or high risk of hypothyroidism, requiring confirmatory diagnostic tests.
Genome assemblies for Chromidotilapia guntheri (Teleostei: Cichlidae) identify a novel candidate gene for vertebrate sex determination, RIN3
Authors: Behrens Kristen A. , Koblmüller Stephan , Kocher Thomas D. 
Published: August 2024

Advances in genome sequencing have greatly accelerated the identification of sex chromosomes in a variety of species. Many of these species have experienced structural rearrangements that reduce recombination between the sex chromosomes, allowing the accumulation of sequence differences over many megabases. Identification of the genes that are responsible for sex determination within these sometimes large regions has proved difficult. Here, we identify an XY sex chromosome system on LG19 in the West African cichlid fish Chromidotilapia guntheri in which the region of differentiation extends over less than 400 kb. We develop high-quality male and female genome assemblies for this species, which confirm the absence of structural variants, and which facilitate the annotation of genes in the region. The peak of differentiation lies within rin3, which has experienced several debilitating mutations on the Y chromosome. We suggest two hypotheses about how these mutations might disrupt endocytosis, leading to Mendelian effects on sexual development.