bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adherence to the mediterranean diet and risk of breast cancer in the European prospective investigation into cancer and nutrition cohort study
Authors: Buckland G. , Travier N. , Cottet V. , González C.A. , Luján‐Barroso L. , Agudo A. , Trichopoulou A. , Lagiou P. , Trichopoulos D. , Peeters P.H. , May A. , Bueno‐de‐Mesquita H.B. , Bvan Duijnhoven F.J. , Key T.J. , Allen N. , Khaw K.T. , Wareham N. , Romieu I. , McCormack V. , Boutron‐Ruault M. , Clavel‐Chapelon F. , Panico S. , Agnoli C. , Palli D. , Tumino R. , Vineis P. , Amiano P. , Barricarte A. , Rodríguez L. , Sanchez M.J. , Chirlaque M.D. , Kaaks R. , Teucher B. , Boeing H. , Bergmann M.M. , Overvad K. , Dahm C.C. , Tjønneland A. , Olsen A. , Manjer J. , Wirfält E. , Hallmans G. , Johansson I. , Lund E. , Hjartåker A. , Skeie G. , Vergnaud A.C. , Norat T. , Romaguera D. , Riboli E. 
Published: November 2012

AbstractEpidemiological evidence suggests that the Mediterranean diet (MD) could reduce the risk of breast cancer (BC). As evidence from the prospective studies remains scarce and conflicting, we investigated the association between adherence to the MD and risk of BC among 335,062 women recruited from 1992 to 2000, in ten European countries, and followed for 11 years on average. Adherence to the MD was estimated through an adapted relative Mediterranean diet (arMED) score excluding alcohol. Cox proportional hazards regression models were used while adjusting for BC risk factors. A total of 9,009 postmenopausal and 1,216 premenopausal first primary incident invasive BC were identified (5,862 estrogen or progesterone receptor positive [ER+/PR+] and 1,018 estrogen and progesterone receptor negative [ER−/PR−]). The arMED was inversely associated with the risk of BC overall and in postmenopausal women (high vs. low arMED score; hazard ratio [HR] = 0.94 [95% confidence interval [CI]: 0.88, 1.00] ptrend = 0.048, and HR = 0.93 [95% CI: 0.87, 0.99] ptrend = 0.037, respectively). The association was more pronounced in ER−/PR− tumors (HR = 0.80 [95% CI: 0.65, 0.99] ptrend = 0.043). The arMED score was not associated with BC in premenopausal women. Our findings show that adherence to a MD excluding alcohol was related to a modest reduced risk of BC in postmenopausal women, and this association was stronger in receptor‐negative tumors. The results support the potential scope for BC prevention through dietary modification.
Understanding long‐term protection of human papillomavirus vaccination against cervical carcinoma: Cancer registry‐based follow‐up
Authors: Rana Muhammad Mohsin , Huhtala Heini , Apter Dan , Eriksson Tiina , Luostarinen Tapio , Natunen Kari , Paavonen Jorma , Pukkala Eero , Lehtinen Matti 
Published: November 2012

AbstractPhase III clinical trials of human papilloma virus (HPV) vaccination have shown ≥95% efficacy against HPV16/18 associated cervical intraepithelial neoplasia (CIN) Grade 2/3. Long‐term surveillance is, however, needed to determine the overall vaccine efficacy (VE) against CIN3 and invasive cervical carcinoma (ICC). During population‐based recruitment between September 2002 and March 2003, 1,749 16− to 17‐year old Finns participated in a multi‐national randomized Phase III HPV6/11/16/18 vaccine (FUTURE II) trial for the determination of VE against HPV16/18 positive CIN2/3. The passive follow‐up started at the country‐wide, population‐based Finnish Cancer Registry (FCR) six months after the active follow‐up and voluntary cross‐vaccination in April 2007. A cluster randomized, population‐based reference cohort of 15,744 unvaccinated, originally 18–19 year old Finns was established in two phases in 2003 and 2005 after the FUTURE II recruitment. We linked these cohorts with the FCR in 2007–2011 (HPV vaccine and placebo cohorts) and 2006–2010 and 2008–2012 (unvaccinated reference cohorts 1 and 2) to compare their incidences of CIN3 and ICC. The four years passive follow‐up resulted in 3,464, 3,444 and 62,876 person years for the HPV6/11/16/18, original placebo and reference cohorts, after excluding cases discovered during the clinical follow‐up and individuals not at risk. The numbers of CIN3 and ICC cases identified were 0 and 0, 3 and 0, 59 and 3 for the HPV6/11/16/18, placebo and the unvaccinated reference cohorts. The corresponding CIN3 incidence rates were 0/100,000 (95% confidence interval 0.0–106.5), 87.1/100,000 (95% CI 17.9–254.5) and 93.8/100,000 (95% CI 71.4–121), respectively. Long‐term surveillance up to 8 years (and longer) post vaccination of the HPV6/11/16/18 vaccine and placebo cohorts, and the unvaccinated reference cohort (not exposed to interventions) for the most stringent efficacy end‐points by passive cancer registry‐based follow‐up is feasible.
An in vitro assessment of the interaction of cadmium selenide quantum dots with DNA, iron, and blood platelets
Authors: Dunpall Rekha , Nejo Adeola Ayodeji , Pullabhotla Viswanadha Srirama Rajasekhar , Opoku Andy R. , Revaprasadu Neerish , Shonhai Addmore 
Published: November 2012

AbstractCadmium selenide (CdSe) quantum dots have gained increased attention for their potential use in biomedical applications. This has raised interest in assessing their toxicity. In this study, water‐soluble, cysteine‐capped CdSe nanocrystals with an average size of 15 nm were prepared through a one‐pot solution‐based method. The CdSe nanoparticles were synthesized in batches in which the concentration of the capping agent was varied with the aim of stabilizing the quantum dot core. The effects of the CdSe quantum dots on DNA stability, aggregation of blood platelets, and reducing activity of iron were evaluated in vitro . DNA damage was observed at a concentration of 200 μg/mL of CdSe quantum dots. Furthermore, the CdSe nanocrystals exhibited high reducing power and chelating activity, suggesting that they may impair the function of haemoglobin by interacting with iron. In addition, the CdSe quantum dots promoted aggregation of blood platelets in a dose dependent manner. © 2012 IUBMB IUBMB Life, 64(12): 995–1002, 2012
Automated fluorescence lifetime imaging plate reader and its application to Förster resonant energy transfer readout of Gag protein aggregation
Authors: Alibhai Dominic , Kelly Douglas J. , Warren Sean , Kumar Sunil , Margineau Anca , Serwa Remigiusz A. , Thinon Emmanuelle , Alexandrov Yuriy , Murray Edward J. , Stuhmeier Frank , Tate Edward W. , Neil Mark A. A. , Dunsby Chris , French Paul M. W. 
Published: November 2012

AbstractFluorescence lifetime measurements can provide quantitative readouts of local fluorophore environment and can be applied to biomolecular interactions via Förster resonant energy transfer (FRET). Fluorescence lifetime imaging (FLIM) can therefore provide a high content analysis (HCA) modality to map protein‐protein interactions (PPIs) with applications in drug discovery, systems biology and basic research. We present here an automated multiwell plate reader able to perform rapid unsupervised optically sectioned FLIM of fixed and live biological samples and illustrate its potential to assay PPIs through application to Gag protein aggregation during the HIV life cycle. We demonstrate both hetero‐FRET and homo‐FRET readouts of protein aggregation and report the first quantitative evaluation of a FLIM HCA assay by generating dose response curves through addition of an inhibitor of Gag myristoylation. Z ′ factors exceeding 0.6 are realised for this FLIM FRET assay. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Cationic closo‐carboranes 2. Do computed 11B and 13C NMR chemical shifts support their experimental availability?
Authors: Hnyk Drahomír , Jayasree Elambalassery G. 
Published: November 2012

Abstract11B and 13C NMR spectra of so‐far experimentally unknown carbon‐rich cationic closo‐carboranes C3Bn–3Hn+ (n = 5, 6, 7, 10, 12) have been calculated at the GIAO‐MP2 level and subsequently analyzed to reveal the nature of bonding in these potentially weakly coordinating cations. All previous rules derived for understanding 11B NMR spectra of borane derivatives can be applied to realistically account for the corresponding shieldings. The correlated wavefunction for n = 5 and, to a lesser extent, for n = 10 seems to be decisive when trying to compute realistic shielding tensors, which is in agreement with the corresponding known dicarbaboranes. For other cluster dimensions noncorrelated wavefunctions also work well, in particular in relation to the corresponding dicarbaboranes. All these observations strongly support the fact that experimental availability of these unique clusters is possible. © 2012 Wiley Periodicals, Inc.
A novel quarter‐wave retardation film for improving viewing angle properties in time‐sequential stereoscopic 3D‐LCDs
Authors: Ishiguro Makoto , Ohmuro Katsufumi , Saitoh Yukito , Takahashi Yuuta , Watanabe Jun , Arai Tsutomu , Ito Yoji , Mihayashi Keiji 
Published: November 2012

AbstractWe have successfully developed a quarter‐wave retardation film (QWF) for wide viewing angle 3D liquid crystal displays (3D‐LCDs) that provides high luminance, low crosstalk, low color change, and low head‐tilt‐angle dependency. It was found that the out‐of‐plane retardation (Rth) of the QWF in the LCD needs to be close to 0 nm in order to improve the 3D display properties at an off‐axis position and that the in‐plane retardation (Re) needs to be adjusted from 120 to 130 nm to achieve low color change with head tilting. We adopted a coating process for making our QWF because of its potential for retardation control. 3D‐LCDs with this QWF whose Rth was nearly zero had high performance and allowed off‐axis other than on‐axis.
Flexible LCDs fabricated with a slit coater: Not requiring an alignment film
Authors: Kimura Munehiro , Honda Kenshin , Yodogawa Satoshi , Ohtsuka Keisuke , Oo Thet Naing , Miyashita Katsuyoshi , Hirata Hajime , Akahane Tadashi 
Published: November 2012

AbstractA homogeneously aligned liquid crystal layer on a substrate film on which it is not necessary to form a liquid crystal alignment film can be assembled by a slit coater. Types of twisted nematic and in‐plane switching flexible liquid crystal displays were demonstrated. The production time can be considerably shortened because of the lack of need for an alignment film. The slit coater method is also applicable to the roll‐to‐roll process.
Social Support Moderates Posttraumatic Stress and General Distress After Disaster
Authors: Arnberg Filip K. , Hultman Christina M. , Michel Per‐Olof , Lundin Tom 
Published: November 2012

Social support buffers the negative impact of stressful events. Less, however, is known about the characteristics of this association in the context of disaster and findings have been discrepant regarding direct and buffering effects. This study tested whether the protective effects of social support differed across levels of exposure severity (i.e., buffered distress) and assessed whether the buffering effect differed between event‐specific and general distress. Participants were 4,600 adult Swedish tourists (44% of invited; 55% women) repatriated within 3 weeks after the 2004 Indian Ocean tsunami. A survey 14 months after the disaster included the Crisis Support Scale, the Impact of Event Scale‐Revised (IES‐R), and the General Health Questionnaire (GHQ‐12). Social support buffered the negative impact of exposure on both outcomes. The support and distress association ranged from very small in participants with low exposure to moderate in those with high exposure (ηp2 = .004 to .053). The buffering effect was not found to differ between the IES‐R and GHQ‐12, F(2, 4589) = 0.87, p = .42. The findings suggest that social support moderates the stressor‐distress relationship after disasters. This study might help explain discrepant findings and point to refinements of postdisaster interventions.
Novel Inorganic Proton‐Conducting Graft Copolymers Based on 4‐Vinyl Benzene Boronic Acid and Vinyl Phosphonic Acid
Authors: Çelik Sevim Ünügür , Bozkurt Ayhan 
Published: November 2012

AbstractAs proton‐conducting polymers, phosphonic acid functional polymers are commonly preferred due to their high proton conductivity in humidified and anhydrous systems. In this work, a new copolymer based on 4‐vinyl benzene boronic acid (VBBA) and vinyl phosphonic acid (VPA) is synthesized and then boronic acid groups are grafted with polyethylene glycol methyl ether to produce more‐flexible materials. The reactions are verified by FTIR spectroscopy and thermal analysis (thermogravimetric analysis (TGA) and DSC). The P content of the samples is analyzed by scanning electron microscopy (SEM)–energy dispersive X‐ray spectrometry (EDS). The ion‐exchange capacity (IEC) of the copolymers is measured and compared with the P content. The proton conductivity is investigated in both humidified conditions and the anhydrous state. In 50% humidity, P(VBBA‐co‐VPA)1:0.5 shows a proton conductivity of 5.3 × 10−3 S cm−1 at 30 °C.
On a characterization of convolutions of Gaussian and Haar distributions
Authors: Feldman Gennadiy 
Published: November 2012

AbstractWe prove some analogues of the well‐known Skitovich–Darmois and Heyde characterization theorems for a second countable locally compact Abelian group X under the assumption that the distributions of the random variables have continuous positive densities with respect to a Haar measure on X and the coefficients in the linear forms considered are topological automorphisms of X.
Extremal spectral properties of Otsuki tori
Authors: Penskoi Alexei V. 
Published: November 2012

AbstractOtsuki tori form a countable family of immersed minimal two‐dimensional tori in the unitary three‐dimensional sphere. According to the El Soufi‐Ilias theorem, the metrics on the Otsuki tori are extremal for some unknown eigenvalues of the Laplace‐Beltrami operator. Despite the fact that the Otsuki tori are defined in quite an implicit way, we find explicitly the numbers of the corresponding extremal eigenvalues. In particular we provide an extremal metric for the third eigenvalue of the torus.
Deficiency indices and spectrum of fourth order difference equations with unbounded coefficients
Authors: Agure John Ogonji , Ambogo David Otieno , Nyamwala Fredrick Oluoch 
Published: November 2012

AbstractUsing subspace theory together with appropriate smoothness and decay conditions, we calculated the deficiency indices and absolutely continuous spectrum of fourth order difference equations with unbounded coefficients. In particular, we found the absolutely continuous spectrum to be \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}${\mathbb {R}}$\end{document} with a spectral multiplicity one.
Performance analysis of networked predictive control systems with data dropout
Authors: Xia Yuanqing , Xie Wen , Zhu Zheng , Wang Ge , Wang Xiaoyun 
Published: November 2012

SUMMARYThis paper is concerned with the design of networked control systems with random network data dropout. It presents a new control scheme, which is termed networked predictive control. This scheme mainly consists of the control prediction generator and network data dropout compensator. Besides, the control prediction generator provides a set of future control predictions to make the closed‐loop system achieve the desired control performance, and the network data dropout compensator removes the effects of the network transmission data dropout. Simulation results are presented to illustrate the effectiveness of the control strategy via comparing with other three existing control schemes. Copyright © 2012 John Wiley & Sons, Ltd.
Reduction of Depressive Symptoms in an Elderly Mexican‐American Female with Type 2 Diabetes Mellitus: A Single‐Subject Study
Authors: Haltiwanger Emily Piven , Galindo David 
Published: November 2012

AbstractThe purpose of this study was to determine if occupation‐based activities improve diabetes self‐management and reduce depressive symptoms in an elderly Mexican‐American woman with type 2 diabetes mellitus (T2DM). There have been no known studies showing occupational therapy's role in self‐care management of T2DM in people with depressive symptoms. The individual in this single‐subject research was evaluated using glycosylated haemoglobin blood tests, four self‐reported standardized questionnaires, participant reflective logs and clinical observations following an 8‐week intervention. The participant improved on all measures, which were sustained 1 month after treatment ended. Clinical implications highlight a new role for occupational therapists providing early intervention in people with diabetes and depression for secondary prevention of complications of uncontrolled diabetes. Research suggestions include multiple single‐subject studies showing occupational therapy contributions. Copyright © 2012 John Wiley & Sons, Ltd.
P‐cadherin functional role is dependent on E‐cadherin cellular context: a proof of concept using the breast cancer model
Authors: Ribeiro Ana Sofia , Sousa Bárbara , Carreto Laura , Mendes Nuno , Nobre Ana Rita , Ricardo Sara , Albergaria André , Cameselle‐Teijeiro Jorge F , Gerhard Rene , Söderberg Ola , Seruca Raquel , Santos Manuel A , Schmitt Fernando , Paredes Joana 
Published: November 2012

AbstractP‐cadherin overexpression is associated with worse breast cancer survival, being a poor prognostic marker as well as a putative therapeutic target for the aggressive triple‐negative and basal‐like carcinomas (TNBCs). Previously, we have shown that P‐cadherin promotes breast cancer invasion of cells where membrane E‐cadherin was maintained; however, it suppresses invasion in models without endogenous cadherins, like melanomas. Here, we investigated if P‐cadherin expression would interfere with the normal adhesion complex and which were the cellular/molecular consequences, constituting, in this way, a new mechanism by which E‐cadherin invasive‐suppressor function was disrupted. Using breast TNBC models, we demonstrated, for the first time, that P‐cadherin co‐localizes with E‐cadherin, promoting cell invasion due to the disruption caused in the interaction between E‐cadherin and cytoplasmic catenins. P‐cadherin also induces cell migration and survival, modifying the expression profile of cells expressing wild‐type E‐cadherin and contributing to alter their cellular behaviour. Additionally, E‐ and P‐cadherin co‐expressing cells significantly enhanced in vivo tumour growth, compared with cells expressing only E‐ or only P‐cadherin. Finally, we still found that co‐expression of both molecules was significantly correlated with high‐grade breast carcinomas, biologically aggressive, and with poor patient survival, being a strong prognostic factor in this disease. Our results show a role for E‐ and P‐cadherin co‐expression in breast cancer progression and highlight the potential benefit of targeting P‐cadherin in the aggressive tumours expressing high levels of this protein. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Multilocus sequence typing (MLST) analysis of Propionibacterium acnes isolates from radical prostatectomy specimens
Authors: Mak Tim N. , Yu Shu‐Han , De Marzo Angelo M. , Brüggemann Holger , Sfanos Karen S. 
Published: November 2012

AbstractBACKGROUNDInflammation is commonly observed in radical prostatectomy specimens, and evidence suggests that inflammation may contribute to prostate carcinogenesis. Multiple microorganisms have been implicated in serving as a stimulus for prostatic inflammation. The pro‐inflammatory anaerobe, Propionibacterium acnes, is ubiquitously found on human skin and is associated with the skin disease acne vulgaris. Recent studies have shown that P. acnes can be detected in prostatectomy specimens by bacterial culture or by culture‐independent molecular techniques.METHODSRadical prostatectomy tissue samples were obtained from 30 prostate cancer patients and subject to both aerobic and anaerobic culture. Cultured species were identified by 16S rDNA gene sequencing. Propionibacterium acnes isolates were typed using multilocus sequence typing (MLST).RESULTSOur study confirmed that P. acnes can be readily cultured from prostatectomy tissues (7 of 30 cases, 23%). In some cases, multiple isolates of P. acnes were cultured as well as other Propionibacterium species, such as P. granulosum and P. avidum. Overall, 9 of 30 cases (30%) were positive for Propionibacterium spp. MLST analyses identified eight different sequence types (STs) among prostate‐derived P. acnes isolates. These STs belong to two clonal complexes, namely CC36 (type I‐2) and CC53/60 (type II), or are CC53/60‐related singletons.CONCLUSIONSMLST typing results indicated that prostate‐derived P. acnes isolates do not fall within the typical skin/acne STs, but rather are characteristic of STs associated with opportunistic infections and/or urethral flora. The MLST typing results argue against the likelihood that prostatectomy‐derived P. acnes isolates represent contamination from skin flora. Prostate 73: 770–777, 2013. © 2012 Wiley Periodicals, Inc.
Optical and electrical properties of ZnO thin films doped with Al, V and Nb
Authors: Angelov Orlin , Lovchinov Konstantin , Dimova‐Malinovska Doriana 
Published: November 2012

AbstractThis study addresses the optical and electrical properties of ZnO thin films doped with Al, V and Nb (ZnO:Al, ZnO:V and ZnO:Nb, respectively) deposited by r.f. magnetron sputtering in Ar atmosphere. The films are deposited on glass substrates without heating and heated at 100 °C, 150 °C and 275 °C. The optical spectra of transmittance and reflectance are measured and the optical band gap of the films is determined. The different films have band gap values in the range of 3.37‐3.57 eV. The films have about 90% transmittance and their resistivity is in the range of 8.5‐2.0 mΩ.cm. The influence of doping elements on the optical and electrical characteristics of the obtained thin films is discussed (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Three‐Dimensional Exploration and Mechano‐Biophysical Analysis of the Inner Structure of Living Cells
Authors: Barroso Álvaro , Woerdemann Mike , Vollmer Angelika , von Bally Gert , Kemper Björn , Denz Cornelia 
Published: November 2012

AbstractA novel mechanobiological method is presented to explore qualitatively and quantitatively the inside of living biological cells in three dimensions, paving the way to sense intracellular changes during dynamic cellular processes. For this purpose, holographic optical tweezers, which allow the versatile manipulation of nanoscopic and microscopic particles by means of tailored light fields, are combined with self‐interference digital holographic microscopy. This biophotonic holographic workstation enables non‐contact, minimally invasive, flexible, high‐precision optical manipulation and accurate 3D tracking of probe particles that are incorporated by phagocytosis in cells, while simultaneously quantitatively phase imaging the cell morphology. In a first model experiment, internalized polystyrene microspheres with 1 μm diameter are three‐dimensionally moved and tracked in order to quantify distances within the intracellular volume with submicrometer accuracy. Results from investigations on cell swelling provoked by osmotic stimulation demonstrate the homogeneous stretching of the cytoskeleton network, and thus that the proposed method provides a new way for the quantitative 3D analysis of the dynamic intracellular morphology.