bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of hypertrophic burn scars by combination laser‐cision and pinhole method using a carbon dioxide laser
Authors: Lee Sang Ju , Yeo In Kwon , Kang Jin Moon , Chung Won Soon , Kim Young Koo , Kim Beom Joon , Park Kui Young 
Published: April 2014

BackgroundHypertrophic burn scars induce cosmetic and functional complications. Although there are various treatment modalities, an ideal method has not yet been found. Recently, numerous laser treatment modalities have been introduced with encouraging results.ObjectiveTo assess the efficacy and safety of combination therapy with laser‐cision and pinhole method using a carbon dioxide (CO2) laser.MethodsWe conducted retrospective chart review of patients with hypertrophic burn scars treated by combination laser‐cision and pinhole method from January 2007 to December 2012.ResultsNine patients with hypertrophic burn scars (mean age 31.2 years; range, 13–52 years) were treated with combination therapy over the past 6 years. Subjects were treated with one to three treatment sessions at 1‐year intervals by laser‐cision and five to eight treatment sessions at 2‐ to 3‐month intervals by pinhole method. Two blinded observers evaluated photographs taken at baseline and 6 months after the final treatment. Compared with baseline, there was a mild to moderate improvement in all the patients (Grades 1–4; mean score: 2.89). The patient satisfaction survey revealed a mean improvement score of 3.11.ConclusionCombination laser‐cision and pinhole method using a CO2 laser may be a new effective treatment option for patients with hypertrophic burn scars. Lasers Surg. Med. 46:380–384, 2014. © 2014 Wiley Periodicals, Inc.
Steel shaft guide products for high productivity
Authors: Mawdsley Colin , Stockwell Matt 
Published: April 2014

AbstractThe Tata Steel mill at Skinningrove in the North East of England produces top hat sections for mineshaft guides in sizes 102 and 150 mm. The top hat section is the technically preferred shaft guide choice for modern deep mine shafts. This paper explores the relative service performance of top hat and square hollow section guides in service. Comparative corrosion performance is reviewed and the paper describes work commissioned by Tata Steel (as Corus) undertaken by Aker Kvaerner Engineering to evaluate relative winding speeds, relative loads and fatigue life in service. The experience of supply to UK Potash mining is discussed and the future view of high capacity hoisting and larger section size market need and availability is assessed.
The Impact of Rehabilitation and Counseling Services on the Labor Market Activity of Social Security Disability Insurance (SSDI) Beneficiaries
Authors: Weathers Robert R. , Bailey Michelle Stegman 
Published: April 2014

AbstractWe use data from a social experiment to estimate the impact of a rehabilitation and counseling program on the labor market activity of newly entitled Social Security Disability Insurance (SSDI) beneficiaries. Our results indicate that the program led to a 4.6 percentage point increase in the receipt of employment services within the first year following random assignment and a 5.1 percentage point increase in participation in the Social Security Administration's Ticket to Work program within the first three years following random assignment. The program led to a 5.3 percentage point increase, or almost 50 percent increase, in employment, and an $831 increase in annual earnings in the second calendar year after the calendar year of random assignment. The employment and earnings impacts are smaller and not statistically significant in the third calendar year following random assignment, and we describe SSDI rules that are consistent with this finding. Our findings indicate that disability reform proposals focusing on restoring the work capacity of people with disabilities can increase the disability employment rate.
Increasing the affinity of selective bZIP‐binding peptides through surface residue redesign
Authors: Kaplan Jenifer B. , Reinke Aaron W. , Keating Amy E. 
Published: April 2014

AbstractThe coiled‐coil dimer is a prevalent protein interaction motif that is important for many cellular processes. The basic leucine‐zipper (bZIP) transcription factors are one family of proteins for which coiled‐coil mediated dimerization is essential for function, and misregulation of bZIPs can lead to disease states including cancer. This makes coiled coils attractive protein–protein interaction targets to disrupt using engineered molecules. Previous work designing peptides to compete with native coiled‐coil interactions focused primarily on designing the core residues of the interface to achieve affinity and specificity. However, folding studies on the model bZIP GCN4 show that coiled‐coil surface residues also contribute to binding affinity. Here we extend a prior study in which peptides were designed to bind tightly and specifically to representative members of each of 20 human bZIP families. These “anti‐bZIP” peptides were designed with an emphasis on target‐binding specificity, with contributions to design‐target specificity and affinity engineered considering only the coiled‐coil core residues. High‐throughput testing using peptide arrays indicated many successes. We have now measured the binding affinities and specificities of anti‐bZIPs that bind to FOS, XBP1, ATF6, and CREBZF in solution and tested whether redesigning the surface residues can increase design–target affinity. Incorporating residues that favor helix formation into the designs increased binding affinities in all cases, providing low‐nanomolar binders of each target. However, changes in surface electrostatic interactions sometimes changed the binding specificity of the designed peptides.
Non‐target effects of two sunflower seed treatments on Orius insidiosus (Hemiptera: Anthocoridae)
Authors: Gontijo Pablo C , Moscardini Valéria F , Michaud JP , Carvalho Geraldo A 
Published: April 2014

AbstractBACKGROUNDSystemic insecticides used as seed treatments are generally considered to be safe for natural enemies. However, predatory insects may feed directly on plants or use plant products to supplement their diet. This study examined whether chlorantraniliprole or thiamethoxam might negatively impact Orius insidiosus (Say) (Hemiptera: Anthocoridae) when bugs utilize sunflowers grown from treated seed.RESULTSWhen eggs of O. insidiosus were laid in the stems of treated sunflower seedlings (two‐leaf stage), thiamethoxam reduced egg viability and the longevity of females hatching from these eggs, whereas chlorantraniliprole reduced female survival. Thiamethoxam, but not chlorantraniliprole, reduced female fertility in six‐leaf‐stage plants. Nymphs exposed to thiamethoxam‐treated seedlings had reduced survival, delayed development and reduced fecundity as adults, relative to other treatments, whereas chlorantraniliprole delayed oviposition. Nymphs exposed to six‐leaf‐stage plants did not differ from controls in either treatment. Adults exposed to treated plants expressed no significant differences among treatments for any parameter evaluated for either plant growth stage.CONCLUSIONThiamethoxam treatment on sunflower seeds caused lethal and sublethal effects on O. insidiosus, whereas chlorantraniliprole was not lethal to any life stage, although sublethal effects were evident. The nymphal stage was most susceptible, and insecticidal toxicity diminished with plant development. © 2014 Society of Chemical Industry
Discrete‐time network‐based control under scheduling and actuator constraints
Authors: Liu Kun , Fridman Emilia 
Published: April 2014

SummaryThis paper is concerned with the solution bounds for discrete‐time networked control systems via delay‐dependent Lyapunov–Krasovskii methods. Solution bounds are widely used for systems with input saturation caused by actuator saturation or by the quantizers with saturation. The time‐delay approach has been developed recently for the stabilization of continuous‐time networked control systems under the round‐robin protocol and under a weighted try‐once‐discard protocol, respectively. Actuator saturation has not been taken into account. In the present paper, for the first time, the time‐delay approach is extended to the stability analysis of the discrete‐time networked control systems under both scheduling protocols and actuators saturation. The communication delays are allowed to be larger than the sampling intervals. A novel Lyapunov‐based method is presented for finding the domain of attraction. Polytopic uncertainties in the system model can be easily included in our analysis. The efficiency of the time‐delay approach is illustrated on the example of a cart–pendulum system. Copyright © 2014 John Wiley & Sons, Ltd.
Finite‐time attitude control of multiple rigid spacecraft using terminal sliding mode
Authors: Zhou Ning , Xia Yuanqing , Wang Meiling , Fu Mengyin 
Published: April 2014

SummaryThis paper investigates the control problem of finite‐time attitude synchronization and tracking for a group of rigid spacecraft in the presence of environmental disturbances. A new fast terminal sliding manifold is developed for multiple spacecraft formation flying under the undirected graph topology. On the basis of the finite‐time control and adaptive control strategies, two novel decentralized finite‐time control laws are proposed to force the spacecraft attitude error dynamics to converge to small regions in finite time, and adaptive control is applied to reject the disturbance. The finite‐time convergence and stability of the closed‐loop system can be guaranteed by Lyapunov theory. Simulation examples are provided to illustrate the feasibility of the control algorithm. Copyright © 2014 John Wiley & Sons, Ltd.
Relevance of Surgery after Embolization of Gastrointestinal and Abdominal Hemorrhage
Authors: Köhler Gernot , Koch Oliver Owen , Antoniou Stavros A. , Mayer Franz , Lechner Michael , Pallwein‐Prettner Leo , Emmanuel Klaus 
Published: April 2014

AbstractBackgroundGastrointestinal and abdominal bleeding can lead to life‐threatening situations. Embolization is considered a feasible and safe treatment option. The relevance of surgery has thus diminished in the past. The aim of the present study was to evaluate the role of surgery in the management of patients after embolization.MethodsWe performed a retrospective single‐center analysis of outcomes after transarterial embolization of acute abdominal and gastrointestinal hemorrhage between January 2009 and December 2012 at the Sisters of Charity Hospital, Linz. Patients were divided into three groups, as follows: upper gastrointestinal bleeding (UGIB), lower gastrointestinal bleeding (LGIB), and abdominal hemorrhage.ResultsFifty‐four patients with 55 bleeding events were included. The bleeding source could be localized angiographically in 80 %, and the primary clinical success rate of embolization was 81.8 % (45/55 cases). Early recurrent bleeding (<30 days) occurred in 18.2 % (10/55) of the patients, and delayed recurrent hemorrhage (>30 days) developed in 3.6 % (2/55). The mean follow‐up was 8.4 months, and data were available for 85.2 % (46/54) of the patients. Surgery after embolization was required in 20.4 % of these patients (11/54). Failure to localize the bleeding site was identified as predictive of recurrent bleeding (p = 0.009). More than one embolization effort increased the risk of complications (p = 0.02) and rebleeding (p = 0.07).ConclusionsSurgery still has an important role after embolization in patients with gastrointestinal and abdominal hemorrhage. One of five patients required surgery in cases of early and delayed rebleeding or because of ischemic complications (2/55 both had ischemic damage of the gallbladder) and bleeding consequences.
La recherche de l’inclusion scolaire à travers les recours offerts aux familles : perspective comparative canadienne dans un contexte francophone minoritaire
Authors: Paré Mona , Bélanger Nathalie 
Published: April 2014

Résumé
Cet article traite de la question des recours offerts en Ontario aux familles dont les enfants sont identifiés comme étant en difficulté, en s’intéressant particulièrement au contexte francophone minoritaire, souvent négligé dans la recherche. Les orientations en faveur d’une approche inclusive de l’éducation encouragent parents et personnel scolaire à travailler conjointement pour assurer des situations d’apprentissage optimales à tous les élèves. La littérature et la recherche jurisprudentielle montrent pourtant que les actions des parents se situent plutôt en aval, quand il s’agit de contester les services que reçoivent leurs enfants. Dans un premier temps, il s’agit d’examiner les orientations politiques en faveur de l’éducation inclusive en Ontario, mais aussi au Manitoba et au Nouveau-Brunswick, qui ont été choisis comme terrains de comparaison en raison de la minorité francophone importante dans ces provinces. Par la suite, les procédures d’appel mises en place pour les parents dans ces contextes bien précis sont identifiées. Enfin, une analyse des affaires portées devant les tribunaux, et particulièrement devant le Tribunal de l’enfance en difficulté de l’Ontario (TEDO), est effectuée, avec une emphase sur les recours par les familles francophones. Les résultats montrent que le TEDO a été saisi moins par des familles francophones qu’anglophones et que la majorité des décisions rendues ont donné raison aux conseils scolaires plutôt qu’aux parents. De plus, malgré une demande parentale en faveur d’une révision de la programmation pédagogique, le TEDO s’est limité à examiner les décisions touchant à l’identification et au placement des élèves, contrairement aux deux provinces examinées en parallèle. Les recours dans les deux autres provinces prennent d’ailleurs d’autres formes qu’en Ontario où les procédures sont particulièrement formalisées, sans pour autant permettre aux parents de mieux se faire entendre. En conclusion, l’efficacité des voies de recours par rapport à l’objectif d’inclusion est discutée.
Extraintestinal nematodes of the red foxVulpes vulpesin north-west Italy
Authors: Magi M. , Guardone L. , Prati M.C. , Mignone W. , Macchioni F. 
Published: April 2014

AbstractExtraintestinal nematodes of the red fox (Vulpes vulpes) are a wide group of parasites that infect wild and domestic carnivores and occasionally humans. Nematodes in the cardiopulmonary system, stomach, urinary apparatus and muscle tissue of 165 red foxes (Vulpes vulpes) from north-west Italy (Liguria and Piedmont) were investigated between 2009 and 2012. Of the cardiopulmonary nematodes, a high prevalence ofAngiostrongylus vasorumandEucoleus aerophilus(syn.Capillaria aerophila) was found, 78.2% and 41.8% respectively;Crenosoma vulpis(15.8%) andFilaroidesspp. (4.8%) were also found.Spirocerca lupi(23.5%),Aonchotheca putorii(syn.Capillaria putorii) (8.6%) andPhysalopteraspp. (2.5%) were detected in the stomach andPearsonema plica(syn.Capillaria plica) (56.8%) in the bladder.Eucoleus boehmi(syn.Capillaria boehmi)was also detected in the nasal cavities of one of the two foxes examined. A coprological examination revealed eggs ofE. aerophilus,A. putorii,S. lupi,Physalopteraspp. and eggs of intestinal parasites. Filarial worms were absent in all the 165 animals examined, nor was there evidence ofTrichinellaspp. in any of the foxes. The foxes were found to host a high prevalence of many species of extraintestinal nematodes. The prevalence ofA. vasorumin foxes found in the present study is among the highest in Europe. In addition, to the best of our knowledge,E. boehmiandFilaroidesspp. have never been reported before in this host in Italy.
Subtypen-spezifisches Training bei Dyslexie
Authors: Brinkhaus Moti , van Ermingen-Marbach Muna , Grande Marion , Reimers Julia , Pape-Neumann Julia , Sturm Walter , Heim Stefan 
Published: April 2014

Kognitive Subtypen von Entwicklungsdyslexie können Defizite vor allem in der Phonologie oder der visuell-räumlichen Aufmerksamkeit haben, die mit hirnfunktionellen Unterschieden zu Normallesern einhergehen. Die subtypenspezifische Aktivierungsänderung durch ein visuelles Aufmerksamkeitstraining wurde bisher noch nicht untersucht.Die vorliegende fMRT-Studie untersucht den Einfluss von defizitspezifischen Trainings vs. Lesetrainings auf die neuronalen Korrelate dyslektischer Subtypen verglichen wiederum mit Normallesern. Dritt- und Viertklässler wurden psychometrischen Tests unterzogen, u. a. zu phonologischen und Aufmerksamkeitsfähigkeiten. Alle Dyslektiker erhielten ein vierwöchiges Training: Dyslektiker mit primär phonologischem Defizit ein rein phonologisches Training, Kinder mit primärem Aufmerksamkeitsdefizit ein Aufmerksamkeitstraining. Ein reines Lesetraining erhielt eine dritte Dyslexiegruppe: Dyslektiker unabhängig von ihrem kognitiven Defizit. Mittels fMRT wurde vor und nach dem Training das Posner Paradigma zur visuell-räumlichen Aufmerksamkeitsausrichtung mit den drei Trainingsgruppen und einer vierten Gruppe, den Normallesern, durchgeführt, um zu untersuchen, wie sich das Training auf die neurofunktionelle Verarbeitung der drei Dyslexiegruppen auswirkt. Die fMRT-Daten ergaben für alle Trainingsgruppen eine signifikante Veränderung im linken inferioren Frontalcortex. Das Maximum dieser Aktivierungsveränderung lag jedoch jeweils an verschiedenen Stellen innerhalb dieser Region: für die Trainingsgruppe Phonologie auf dem GFI in der Broca-Region, für die Trainingsgruppen Aufmerksamkeit und Lesen jeweils im Sulcus frontalis inferior. Die drei Gruppen verarbeiten möglicherweise verschiedene Funktionen in dieser sehr heterogenen Region. Das linkshemisphärische Aktivierungsmuster könnte somit auf unterschiedliche Kompensation nach den verschiedenen Dyslexie-Trainings hinweisen, die nicht in klassischen rechts-hemisphärischen Aufmerksamkeitsarealen, sondern im linkshemispärischen Sprachnetzwerk lokalisiert sind.
Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen
Authors: Liakath-Ali Kifayathullah , Vancollie Valerie E. , Heath Emma , Smedley Damian P. , Estabel Jeanne , Sunter David , DiTommaso Tia , White Jacqueline K. , Ramirez-Solis Ramiro , Smyth Ian , Steel Karen P. , Watt Fiona M. 
Published: April 2014

AbstractPermanent stop-and-shop large-scale mouse mutant resources provide an excellent platform to decipher tissue phenogenomics. Here we analyse skin from 538 knockout mouse mutants generated by the Sanger Institute Mouse Genetics Project. We optimize immunolabelling of tail epidermal wholemounts to allow systematic annotation of hair follicle, sebaceous gland and interfollicular epidermal abnormalities using ontology terms from the Mammalian Phenotype Ontology. Of the 50 mutants with an epidermal phenotype, 9 map to human genetic conditions with skin abnormalities. Some mutant genes are expressed in the skin, whereas others are not, indicating systemic effects. One phenotype is affected by diet and several are incompletely penetrant. In-depth analysis of three mutants, Krt76, Myo5a (a model of human Griscelli syndrome) and Mysm1, provides validation of the screen. Our study is the first large-scale genome-wide tissue phenotype screen from the International Knockout Mouse Consortium and provides an open access resource for the scientific community.
Enhanced Antibacterial Activity of Silver Nanoparticles/Halloysite Nanotubes/Graphene Nanocomposites with Sandwich-Like Structure
Authors: Yu Liang , Zhang Yatao , Zhang Bing , Liu Jindun 
Published: April 2014

AbstractA sandwich-like antibacterial reagent (Ag/HNTs/rGO) was constructed through the direct growth of silver nanoparticles on the surface graphene-based HNTs nanosheets. Herein, various nanomaterials were combined by adhesion effect of DOPA after self-polymerization. Ag/HNTs/rGO posses enhanced antibacterial ability against E. coli and S. aureus compared with individual silver nanoparticles, rGO nanosheets or their nanocomposites.
TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli
Authors: Munne Pauliina M. , Gu Yuexi , Tumiati Manuela , Gao Ping , Koopal Sonja , Uusivirta Sanna , Sawicki Janet , Wei Gong-Hong , Kuznetsov Sergey G. 
Published: April 2014

AbstractMultiple observations suggest a cell type-specific role forTP53in mammary epithelia. We developed anin vitroassay, in which primary mouse mammary epithelial cells (mMECs) progressed from lumenal to basal-like phenotypes based on expression of Krt18 or ΔNp63, respectively. Such transition was markedly delayed inTrp53−/−mMECs suggesting that Trp53 is required for specification of the basal, but not lumenal cells. Evidence from human basal-like cell lines suggests that TP53 may support the activity of ΔNp63 by preventing its translocation from nucleoplasm into nucleoli. In human lumenal cells, activation of TP53 by inhibiting MDM2 or BRCA1 restored the nucleoplasmic expression of ΔNp63.Trp53−/−mMECs eventually lost epithelial features resulting in upregulation of MDM2 and translocation of ΔNp63 into nucleoli. We propose thatTP63may contribute toTP53-mediated oncogenic transformation of epithelial cells and shed light on tissue- and cell type-specific biases observed for TP53-related cancers.
RNA–RNA interactions and pre-mRNA mislocalization as drivers of group II intron loss from nuclear genomes
Authors: Qu Guosheng , Dong Xiaolong , Piazza Carol Lyn , Chalamcharla Venkata R. , Lutz Sheila , Curcio M. Joan , Belfort Marlene 
Published: April 2014

Significance
For over three decades, group II introns have been conjectured to be the ancestors of splicesomal introns, but there are no group II introns in extant nuclear genomes. Might these introns have been expunged as spliceosomal introns proliferated? We showed previously that nuclear expression of a group II intron in yeast resulted specifically in down-regulation of its host gene. Here, we report on the discovery that pre-mRNA mislocalization and a consequent interaction between the pre-mRNA or intron and spliced mRNA together account for the mechanism of gene silencing. Our data support the hypothesis that such roadblocks to gene expression resulted in purging of group II introns from nuclear genomes while promoting the evolution of spliceosomal introns.
Ultrasonic Characterization of Unyeasted Bread Dough of Different Sodium Chloride Concentrations
Authors: Koksel Filiz , Strybulevych Anatoliy , Page John H. , Scanlon Martin G. 
Published: April 2014

ABSTRACTAltering the properties of dough by reducing sodium chloride (NaCl) content affects aeration processes during mixing. The effect of NaCl concentration on the bubble size distribution (BSD) in unyeasted doughs was investigated by an ultrasonic transmission technique through analysis of frequency‐dependent ultrasonic phase velocity and attenuation coefficient. As NaCl concentration was decreased, the volume fraction of gas in the dough increased, resulting in a larger attenuation coefficient for the dough. From the peak in attenuation coefficient, estimates of the median radius and the width of the lognormal BSD in the dough were extracted, both of which were sensitive to the dough's NaCl concentration. As NaCl concentration was reduced, the bubble radius decreased and the width of the distribution increased, in accordance with expectations arising from changes in the dough's consistency. Over the course of 150 min, the radius increased (40–50%) and the width decreased (4–8%) for all dough formulations, consistent with changes in the BSD arising from disproportionation. These dynamic changes demonstrate that dough is an interesting soft material whose formulation can be manipulated to enable it to possess different BSDs; the diffusively driven evolution in these bubble sizes can be investigated noninvasively with ultrasound.