bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macrophage responses to implants: prospects for personalized medicine
Authors: Kzhyshkowska Julia , Gudima Alexandru , Riabov Vladimir , Dollinger Camille , Lavalle Philippe , Vrana Nihal Engin 
Published: July 2015

Abstract
Implants, transplants, and implantable biomedical devices are mainstream solutions for a wide variety of human pathologies. One of the persistent problems around nondegradable metallic and polymeric implants is failure of macrophages to resolve the inflammation and their tendency to stay in a state, named “frustrated phagocytosis.” During the initial phase, proinflammatory macrophages induce acute reactions to trauma and foreign materials, whereas tolerogenic anti-inflammatory macrophages control resolution of inflammation and induce the subsequent healing stage. However, implanted materials can induce a mixed pro/anti-inflammatory phenotype, supporting chronic inflammatory reactions accompanied by microbial contamination and resulting in implant failure. Several materials based on natural polymers for improved interaction with host tissue or surfaces that release anti-inflammatory drugs/bioactive agents have been developed for implant coating to reduce implant rejection. However, no definitive, long-term solution to avoid adverse immune responses to the implanted materials is available to date. The prevention of implant-associated infections or chronic inflammation by manipulating the macrophage phenotype is a promising strategy to improve implant acceptance. The immunomodulatory properties of currently available implant coatings need to be improved to develop personalized therapeutic solutions. Human primary macrophages exposed to the implantable materials ex vivo can be used to predict the individual’s reactions and allow selection of an optimal coating composition. Our review describes current understanding of the mechanisms of macrophage interactions with implantable materials and outlines the prospects for use of human primary macrophages for diagnostic and therapeutic approaches to personalized implant therapy.
BREATH: Web-Based Self-Management for Psychological Adjustment After Primary Breast Cancer—Results of a Multicenter Randomized Controlled Trial
Authors: van den Berg Sanne W. , Gielissen Marieke F.M. , Custers José A.E. , van der Graaf Winette T.A. , Ottevanger Petronella B. , Prins Judith B. 
Published: July 2015

Purpose Early breast cancer survivors (BCSs) report high unmet care needs, and easily accessible care is not routinely available for this growing population. The Breast Cancer E-Health (BREATH) trial is a Web-based self-management intervention to support the psychological adjustment of women after primary treatment, by reducing distress and improving empowerment. Patients and Methods This multicenter, randomized, controlled, parallel-group trial evaluated whether care as usual (CAU) plus BREATH is superior to CAU alone. BREATH is delivered in sixteen fully automated weekly modules covering early survivorship issues. Two to 4 months post-treatment, BCSs were randomly assigned to receive CAU + BREATH (n = 70) or CAU alone (n = 80) using a stratified block design (ratio 1:1). Primary outcomes were distress (Symptom Checklist-90) and empowerment (Cancer Empowerment Questionnaire), assessed before random assignment (baseline, T0) and after 4 (T1), 6 (T2), and 10 months (T3) of follow-up. Statistical (analysis of covariance) and clinical effects (reliable change index) were tested in an intention-to-treat analysis (T0 to T1). Follow-up effects (T0 to T3) were assessed in assessment completers. Results CAU + BREATH participants reported significantly less distress than CAU-alone participants (−7.79; 95% CI, −14.31 to −1.27; P = .02) with a small-to-medium effect size (d = 0.33), but empowerment was not affected (−1.71; 95% CI, 5.20 to −1.79; P = .34). More CAU + BREATH participants (39 of 70 [56%]; 95% CI, 44.1 to 66.8) than CAU-alone participants (32 of 80 [40%]; 95% CI, 30.0 to 51.0) showed clinically significant improvement (P = .03). This clinical effect was most prominent in low-distress BCSs. Secondary outcomes confirmed primary outcomes. There were no between-group differences in primary outcomes during follow-up. Conclusion Access to BREATH reduced distress among BCSs, but this effect was not sustained during follow-up.
Phase II Study of Lapatinib in Combination With Trastuzumab in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer: Clinical Outcomes and Predictive Value of Early [18F]Fluorodeoxyglucose Positron Emission Tomography Imaging (TBCRC 003)
Authors: Lin Nancy U. , Guo Hao , Yap Jeffrey T. , Mayer Ingrid A. , Falkson Carla I. , Hobday Timothy J. , Dees E. Claire , Richardson Andrea L. , Nanda Rita , Rimawi Mothaffar F. , Ryabin Nicole , Najita Julie S. , Barry William T. , Arteaga Carlos L. , Wolff Antonio C. , Krop Ian E. , Winer Eric P. , Van den Abbeele Annick D. 
Published: July 2015

Purpose Lapatinib plus trastuzumab improves outcomes relative to lapatinib alone in heavily pretreated, human epidermal growth factor receptor 2–positive metastatic breast cancer (MBC). We tested the combination in the earlier-line setting and explored the predictive value of [18F]fluorodeoxyglucose positron emission tomography ([18F]FDG-PET) for clinical outcomes. Patients and Methods Two cohorts were enrolled (cohort 1: no prior trastuzumab for MBC and ≥ 1 year from adjuvant trastuzumab, if given; cohort 2: one to two lines of chemotherapy including trastuzumab for MBC and/or recurrence < 1 year from adjuvant trastuzumab). The primary end point was objective response rate by RECIST v1.0; secondary end points included clinical benefit rate (complete response plus partial response plus stable disease ≥ 24 weeks) and progression-free survival. [18F]FDG-PET scans were acquired at baseline, week 1, and week 8. Associations between metabolic response and clinical outcomes were explored. Results Eighty-seven patients were registered (85 were evaluable for efficacy). The confirmed objective response rate was 50.0% (95% CI, 33.8% to 66.2%) in cohort 1 and 22.2% (95% CI, 11.3% to 37.3%) in cohort 2. Clinical benefit rate was 57.5% (95% CI, 40.9% to 73.0%) in cohort 1 and 40.0% (95% CI, 25.7% to 55.7%) in cohort 2. Median progression-free survival was 7.4 and 5.3 months, respectively. Lack of week-1 [18F]FDG-PET/computed tomography ([18F]FDG-PET/CT) response was associated with failure to achieve an objective response by RECIST (negative predictive value, 91% [95% CI, 74% to 100%] for cohort 1 and 91% [95% CI, 79% to 100%] for cohort 2). Conclusion Early use of lapatinib and trastuzumab is active in human epidermal growth factor receptor 2–positive MBC. Week-1 [18F]FDG-PET/CT may allow selection of patients who can be treated with targeted regimens and spared the toxicity of chemotherapy.
Phase III Multinational, Randomized, Double-Blind, Placebo-Controlled Study of Tivantinib (ARQ 197) Plus Erlotinib Versus Erlotinib Alone in Previously Treated Patients With Locally Advanced or Metastatic Nonsquamous Non–Small-Cell Lung Cancer
Authors: Scagliotti Giorgio , von Pawel Joachim , Novello Silvia , Ramlau Rodryg , Favaretto Adolfo , Barlesi Fabrice , Akerley Wallace , Orlov Sergey , Santoro Armando , Spigel David , Hirsh Vera , Shepherd Frances A. , Sequist Lecia V. , Sandler Alan , Ross Jeffrey S. , Wang Qiang , von Roemeling Reinhard , Shuster Dale , Schwartz Brian 
Published: July 2015

Purpose Tivantinib, a MET receptor tyrosine kinase inhibitor, demonstrated increased anticancer activity in preclinical and early clinical studies when combined with erlotinib. Our study aimed to confirm efficacy and safety of the combination in previously treated patients with non–small-cell lung cancer (NSCLC). Patients and Methods Patients with advanced nonsquamous NSCLC previously treated with one to two systemic regimens, including a platinum doublet, were randomly assigned at a 1:1 ratio to receive erlotinib 150 mg daily plus oral tivantinib 360 mg twice daily (E + T) or erlotinib plus placebo (E + P) until disease progression. Tumor specimens were evaluated for EGFR and KRAS mutations, MET expression, and MET gene amplification. The primary end point was overall survival (OS). Secondary and exploratory objectives included progression-free survival (PFS), OS in molecular subgroups, and safety. Results The study enrolled 1,048 patients and was discontinued for futility at the interim analysis. OS did not improve with E + T versus E + P (median OS, 8.5 v 7.8 months, respectively; hazard ratio [HR], 0.98; 95% CI, 0.84 to 1.15; P = .81), even though PFS increased (median PFS, 3.6 v 1.9 months; HR, 0.74; 95% CI, 0.62 to 0.89; P < .001). Exploratory subgroup analyses suggested OS improvement in patients with high MET expression (HR, 0.70; 95% CI, 0.49 to 1.01). Most common adverse events occurring with E + T versus E + P were rash (33.1% v 37.3%, respectively), diarrhea (34.6% v 41.0%), asthenia or fatigue (43.5% v 38.1%), and neutropenia (grade 3 to 4; 8.5% v 0.8%). Conclusion E + T was well tolerated and increased PFS but did not improve OS in the overall nonsquamous NSCLC population.
Heart Failure and Asymptomatic Left Ventricular Systolic Dysfunction in Lymphoma Survivors Treated With Autologous Stem-Cell Transplantation: A National Cross-Sectional Study
Authors: Murbraech Klaus , Smeland Knut B. , Holte Harald , Loge Jon Håvard , Lund May Brit , Wethal Torgeir , Holte Espen , Rösner Assami , Dalen Håvard , Kvaløy Stein , Falk Ragnhild S. , Aakhus Svend , Kiserud Cecilie E. 
Published: July 2015

Purpose We aimed to determine the prevalence of left ventricular systolic dysfunction (LVSD), including symptomatic (ie, heart failure [HF]) and asymptomatic LVSD in adult lymphoma survivors (LSs) after autologous hematopoietic stem-cell transplantation (auto-HCT) and to identify risk factors for LVSD in this population. Patients and Methods All LSs treated with auto-HCT as adults in Norway from 1987 to 2008 were eligible for this national cross-sectional study. Asymptomatic LVSD was defined as left ventricular ejection fraction less than 50% by echocardiography, and HF was defined according to current recommendations. The results in LSs were compared with those found in an age- and sex-matched (1:1) control group. Results We examined 274 LSs (69% of all eligible survivors); 62% were men, the mean (± standard deviation) age was 56 ± 12 years, and mean follow-up time from lymphoma diagnosis was 13 ± 6 years. The mean cumulative doxorubicin dose was 316 ± 111 mg/m2, and 35% of LSs had received additional radiation therapy involving the heart. We found LVSD in 15.7% of the LSs, of whom 5.1% were asymptomatic. HF patients were symptomatically mildly affected, with 8.8% of all LSs classified as New York Heart Association class II, whereas more severe HF was rare (1.8%). Compared with controls, LSs had a substantially increased LVSD risk (odds ratio, 6.6; 95% CI, 2.5 to 17.6; P < .001). A doxorubicin dose ≥ 300 mg/m2 and cardiac radiation therapy dose greater than 30 Gy were independent risk factors for LVSD. Conclusion LVSD was frequent and HF more prevalent than previously reported in LSs after auto-HCT. Our results may help to identify LSs at increased LVSD risk and can serve as a basis for targeted surveillance strategies.
Long-Term Outcomes Following Therapy in Differentiated Thyroid Carcinoma: NTCTCS Registry Analysis 1987–2012
Authors: Carhill Aubrey A. , Litofsky Danielle R. , Ross Douglas S. , Jonklaas Jacqueline , Cooper David S. , Brierley James D. , Ladenson Paul W. , Ain Kenneth B. , Fein Henry G. , Haugen Bryan R. , Magner James , Skarulis Monica C. , Steward David L. , Xing Mingxhao , Maxon Harry R. , Sherman Steven I. 
Published: July 2015

Context:
Initial treatments for patients with differentiated thyroid cancer are supported primarily by single-institution, retrospective studies, with limited follow-up and low event rates. We report updated analyses of long-term outcomes after treatment in patients with differentiated thyroid cancer.

Objective:
The objective was to examine effects of initial therapies on outcomes.

Design/Setting:
This was a prospective multi-institutional registry.

Patients:
A total of 4941 patients, median follow-up, 6 years, participated.

Intervention:
Interventions included total/near-total thyroidectomy (T/NTT), postoperative radioiodine (RAI), and thyroid hormone suppression therapy (THST).

Main Outcome Measure:
Main outcome measures were overall survival (OS) and disease-free survival using product limit and proportional hazards analyses.

Results:
Improved OS was noted in NTCTCS stage III patients who received RAI (risk ratio [RR], 0.66; P = .04) and stage IV patients who received both T/NTT and RAI (RR, 0.66 and 0.70; combined P = .049). In all stages, moderate THST (TSH maintained subnormal-normal) was associated with significantly improved OS (RR stages I-IV: 0.13, 0.09, 0.13, 0.33) and disease-free survival (RR stages I-III: 0.52, 0.40, 0.18); no additional survival benefit was achieved with more aggressive THST (TSH maintained undetectable-subnormal). This remained true, even when distant metastatic disease was diagnosed during follow-up. Lower initial stage and moderate THST were independent predictors of improved OS during follow-up years 1–3.

Conclusions:
We confirm previous findings that T/NTT followed by RAI is associated with benefit in high-risk patients, but not in low-risk patients. In contrast with earlier reports, moderate THST is associated with better outcomes across all stages, and aggressive THST may not be warranted even in patients diagnosed with distant metastatic disease during follow-up. Moderate THST continued at least 3 years after diagnosis may be indicated in high-risk patients.
Photoisomerization and Photoinduced Intramolecular Hydrogen Atom Transfer of 2-[2-(2-Pyrrolyl)ethenyl]pyridine Derivatives
Authors: Kurihara Seiya , Nishimura Yoshinobu , Arai Tatsuo 
Published: July 2015

Abstract
Introduction of an electron-donating methoxy group to 2-[2-(2-pyrrolyl)ethenyl]pyridine, which undergoes photoinduced intramolecular hydrogen atom transfer and one-way trans-to-cis photoisomerization, induced significant changes in these photochemical behaviors.
An Existential Psychoanalyst in the Literary Therapy Genre: The Representation of a Psychoanalytic Encounter in Irvin Yalom’s The Schopenhauer Cure
Authors: Huang Yen‐Chi 
Published: July 2015

Abstract
The aim of this paper is to describe the fictionalisation of psychoanalysis in the literary therapy genre written by psychotherapists. Being a psychotherapist, Irvin Yalom has written and published several literary therapy novels. The Schopenhauer Cure (2006) presents a psychoanalytic encounter with focus on the patient’s interpersonal issues in a group therapy session and draws a parallel line between fictional patients and the philosopher Arthur Schopenhauer. The fictionalisation of patients’ psychological symptoms and the way therapists examine themselves in the therapeutic milieu in The Schopenhauer Cure correspond to the fundamental concerns of isolation, meaninglessness, death and freedom in existential psychotherapy. I explore the literary representation of the psychotherapist and therapist-patient relationship and the therapeutic encounter in The Schopenhauer Cure in the context of how fictional narratives can be read as a form of highlighting the psychoanalytic encounter
Parametric programming of industrial robots
Authors: Szulczyński Paweł , Kozłowski Krzysztof 
Published: July 2015

Abstract
This article proposes the use of parametric design software, commonly used by architects, in order to obtain complex trajectory and program code for industrial robots. The paper describes the drawbacks of existing solutions and proposes a new script to obtain a correct program. The result of the algorithm was verified experimentally.
The Navier–Stokes–Fourier system: From weak solutions to numerical analysis
Authors: Feireisl Eduard 
Published: July 2015

Abstract
We discuss the impact of certain recent results concerning stability of weak solutions to the complete Navier–Stokes–Fourier system
on the problem of convergence of the associated numerical schemes. In particular, we show that solutions of certain numerical schemes converge
unconditionally to the exact solution as long as the numerical solutions remain bounded.
Analysis of the Accuracy of Uncertainty Noise Measurement
Authors: Przysucha Bartosz , Batko Wojciech , Szeląg Agata 
Published: July 2015

AbstractThe paper formulates some objections to the methods of evaluation of uncertainty in noise measurement which are presented in two standards: ISO 9612 (2009) and DIN 45641 (1990). In particular, it focuses on approximation of an equivalent sound level by a function which depends on the arithmetic average of sound levels. Depending on the nature of a random sample the exact value of the equivalent sound level may be significantly different from an approximate one, which might lead to erroneous estimation of the uncertainty of noise indicators. The article presents an analysis of this problem and the adequacy of the solution depending on the type of a random sample.
Recognition of Acoustic Signals of Loaded Synchronous Motor Using FFT, MSAF-5 and LSVM
Authors: Glowacz Adam 
Published: July 2015

AbstractThis article discusses a system of recognition of acoustic signals of loaded synchronous motor. This software can recognize various types of incipient failures by means of analysis of the acoustic signals. Proposed approach uses the acoustic signals generated by loaded synchronous motor. A plan of study of the acoustic signals of loaded synchronous motor is proposed. Studies include following states: healthy loaded synchronous motor, loaded synchronous motor with shorted stator coil, loaded synchronous motor with shorted stator coil and broken coil, loaded synchronous motor with shorted stator coil and two broken coils. The methods such as FFT, method of selection of amplitudes of frequencies (MSAF-5), Linear Support Vector Machine were used to identify specific state of the motor. The proposed approach can keep high recognition rate and reduce the maintenance cost of synchronous motors.
Real-Time Acoustic Phenomena Modelling for Computer Games Audio Engine
Authors: Miga Bartłomiej , Ziółko Bartosz 
Published: July 2015

Abstract
This article presents an efficient method of modelling acoustic phenomena for real-time applications such as computer games. Simplified models of reflections, transmission, and medium attenuation are described along with assessments conducted by a professional sound designer. The article introduces representation of sound phenomena using digital filters for further digital audio processing.
Frequency of the Audiometric Notch Following Excessive Noise Exposure
Authors: Ristovska Lidija , Jachova Zora , Atanasova Nikica 
Published: July 2015

AbstractThe aim of the study was to determine the configuration of pathologic audiograms in patients with excessive noise exposure, and to calculate the frequency of notches in the audiogram in patients with and without excessive noise exposure by avoiding the effect of age-related hearing loss. We have analyzed 514 audiograms of 257 patients aged between 20 to 50 years: 240 patients (mean age of 38.7 years) with excessive noise exposure and 17 patients (mean age of 41.2 years) with notches in the audiogram, but without a history of excessive noise exposure. For statistical data analysis we have used the Chi-square test and Fisher exact test with the level of significancep< 0.05. Pathologic audiograms were classified into five different types: Slope at 4000 Hz (0.8%), Slope at 2000 Hz (15.1%), Notch at 4000 Hz (67.4%), Notch at 2000 Hz (0.8%), Flat (8.9%), and 7% were out of this classification. A total of 190 (79.2%) patients with excessive noise exposure had a notch in the audiogram. Left ear notches were the most common. Among the patients with notched audiograms, 91.8% had a history of excessive noise exposure, either occupational or nonoccupational, and 8.2% did not report any excessive noise exposure.
On Certain Practical Issues Relating to Construction of the In-duct Single Mode Synthesizer
Authors: Gorazd Łukasz , Snakowska Anna , Jurkiewicz Jerzy , Flach Artur 
Published: July 2015

Abstract
It is convenient to have a device and a method of generating single cut-on modes in cylindrical hard-walled waveguides or at least in laboratory models of such systems. This allows to examine, among other things, properties of various active and/or passive elements inserted in a cylindrical duct by testing them in conditions when the incident (input) wave comprises only one cut-on mode and determining the reflection and transmission coefficients for single selected incident modes. As it has been already demonstrated by the present authors, it is possible to generate single cut-on modes in a circular duct using a small (although increasing with mode order) number of acoustic monopoles arranged properly on a duct cross-section and driven with appropriate acoustic volume amplitudes and phases. Laboratory models of such sources are proposed in this paper and results of tests verifying their directional properties are presented. The other technical issue relating to practical utilization of the proposed method is the possible error introduced by the apparatus used for scanning the acoustic field inside the duct model. It is shown that insertion of the measuring probe changes the total energy radiated into the free space only by a fraction of a decibel.
Research on the Impact of Amplitude of Vibrations on Electrical Parameters of Vibroarc Weld Overlay in Argon
Authors: Nikolov Mitko Ivanov 
Published: July 2015

Abstract
The research is taken on the vibroarc welding apparatus ENTON-60 equipped with an axial non-inertial vibrator in argon shield. The criteria used for assessing the flow of the electric arc process and the formation of weld overlay clad surfaces are: short circuit voltage, voltage at the start of arc combustion, short circuit amperage, and amperage at the end of arc combustion. Wire electrode‘s vibrating frequency is considered as an input variable of the cybernetic model. It has been found that amplitude of vibrations has a significant impact on the vibroarc process - voltage parameters and welding current ratio, as the minimum amperage of short circuit and the lowest voltage at the start of arc combustion is realized at 2 mm amplitude of vibrations.
Study of Injection Process Capability in Production of Plastic Boxes
Authors: Lestyánszka Škůrková Katarína , Kudičová Jozefína 
Published: July 2015

Abstract
Ensuring the process capability currently means the warranty that produced products will be in accordance with requirements, both on the company‘s as well as customer‘s side. This study focuses on the statistical control of injection process capability in serial production in a company focusing on products for healthcare. The injection process is evaluated by control charts, specifically by control chart for average and range ( x̄ , R). As the results showed, based on the chart for average and range, we are able to say that the injection process is under statistical control. The requirement for process capability was met; the indices of process capability Cp and Cpk are higher than the determined value 1.33. The normality of measured values was verified by histogram. The obtained values are: Cp = 1.85 and Cpk = 1.82. Therefore, we may consider the process as capable.