bluuebunny/crossref_metadata_2025_split huggingface dataset:
The accessory organ, a scolopidial sensory organ, in the cave cricket Troglophilus neglectus (Orthoptera: Ensifera: Rhaphidophoridae)
Authors: Strauß Johannes , Stritih Nataša 
Published: February 2015

AbstractMechanoreceptor organs occur in great diversity in insect legs. This study investigates sensory organs in the leg of atympanate cave crickets (Troglophilus neglectus KRAUSS, 1879) by neuronal tracing. Previously, the subgenual and the intermediate organs were recognised in the subgenual organ complex, lacking the tympanal membranes present for example in the tibial hearing organs of Gryllidae and Tettigoniidae. We document the presence of the accessory organ in T. neglectus. This scolopidial organ is located in the posterior tibia close to the subgenual organ and can be identified by position, innervation and orientation of the dendrites of sensory neurons. The main motor nerve in the leg innervates a part of the subgenual organ and the accessory organ. The dendrites of sensory neurons in the accessory organ are characteristically bent in proximo‐dorsal direction, while the subgenual organ dendrites run distally along the longitudinal axis of the leg. The accessory organ contains 6–10 scolopidial sensilla, and no differences in neuroanatomy occur between the three thoracic leg pairs. Hence, the subgenual organ complex in cave crickets is more complex than previously known. The wider taxonomic distribution of the accessory scolopidial organ among orthopteroid insects is inconsistent, indicating its repeated losses or convergent evolution.
Aromatic stacking interactions govern catalysis in aryl‐alcohol oxidase
Authors: Ferreira Patricia , Hernández‐Ortega Aitor , Lucas Fátima , Carro Juan , Herguedas Beatriz , Borrelli Kenneth W. , Guallar Victor , Martínez Angel T. , Medina Milagros 
Published: February 2015

Aryl‐alcohol oxidase (AAO, EC 1.1.3.7) generates H2O2 for lignin degradation at the expense of benzylic and other π system‐containing primary alcohols, which are oxidized to the corresponding aldehydes. Ligand diffusion studies on Pleurotus eryngii AAO showed a T‐shaped stacking interaction between the Tyr92 side chain and the alcohol substrate at the catalytically competent position for concerted hydride and proton transfers. Bi‐substrate kinetics analysis revealed that reactions with 3‐chloro‐ or 3‐fluorobenzyl alcohols (halogen substituents) proceed via a ping–pong mechanism. However, mono‐ and dimethoxylated substituents (in 4‐methoxybenzyl and 3,4‐dimethoxybenzyl alcohols) altered the mechanism and a ternary complex was formed. Electron‐withdrawing substituents resulted in lower quantum mechanics stacking energies between aldehyde and the tyrosine side chain, contributing to product release, in agreement with the ping–pong mechanism observed in 3‐chloro‐ and 3‐fluorobenzyl alcohol kinetics analysis. In contrast, the higher stacking energies when electron donor substituents are present result in reaction of O2 with the flavin through a ternary complex, in agreement with the kinetics of methoxylated alcohols. The contribution of Tyr92 to the AAO reaction mechanism was investigated by calculation of stacking interaction energies and site‐directed mutagenesis. Replacement of Tyr92 by phenylalanine does not alter the AAO kinetic constants (on 4‐methoxybenzyl alcohol), most probably because the stacking interaction is still possible. However, introduction of a tryptophan residue at this position strongly reduced the affinity for the substrate (i.e. the pre‐steady state Kd and steady‐state Km increase by 150‐fold and 75‐fold, respectively), and therefore the steady‐state catalytic efficiency, suggesting that proper stacking is impossible with this bulky residue. The above results confirm the role of Tyr92 in substrate binding, thus governing the kinetic mechanism in AAO.
Impacts of uncertain project duration and asymmetric risk sensitivity information in project management
Authors: Yang Kai , Zhao Ruiqing , Lan Yanfei 
Published: February 2015

AbstractThis paper investigates the impacts of uncertain project duration and asymmetric risk sensitivity information on the structure of incentive contract and profits in project management where a risk‐neutral project manager (she) engages a risk‐averse contractor (he) to complete a project. The project manager offers a duration‐based incentive contract to the contractor to ensure that he invests his effort to shorten the project duration and reports his risk sensitivity information truthfully. Within the framework of principal‐agent theory, we first develop a duration‐based incentive contract model, and then derive the optimal contract mechanism by solving its equivalent optimal control problem with Pontryagin maximum principle. We show that if the contractor is highly risk averse and the project duration is highly volatile, the project manager should lower the penalty term to motivate the contractor to make duration‐reduction efforts. Moreover, comparing with the symmetric information scenario, we find that the project manager distorts the penalty term for all contractor's risk types (but the lowest) downward. Our results show that the project manager is more willing to acquire the contractor's risk sensitivity information under the uncertain project duration. The results also suggest that from the project manager's perspective, it is beneficial to have better information about the contractor's risk sensitivity by using a numerical analysis.
Minimal Truthmakers
Authors: O'Conaill Donnchadh , Tahko Tuomas E. 
Published: February 2015

AbstractA minimal truthmaker for a given proposition is the smallest portion of reality which makes this proposition true. Minimal truthmakers are frequently mentioned in the literature, but there has been no systematic account of what they are or of their importance. In this article we shall clarify the notion of a minimal truthmaker and argue that there is reason to think that at least some propositions have minimal truthmakers. We shall then argue that the notion can play a useful role in truthmaker theory, by helping to explain the truth of certain propositions as precisely as possible.
The Priority and Posteriority of Right
Authors: Garthoff Jon 
Published: February 2015

AbstractIn this article I articulate two pairs of theses about the relationship between the right and the good and I sketch an account of morality that systematically vindicates all four theses, despite a nearly universal consensus that they are not all true. In the first half I elucidate and motivate the theses and explain why leading ethical theorists maintain that at least one of them is false; in the second half I present the outlines of an account of the relationship between the right and the good satisfying all four theses.
Advances in Shell Buckling: Theory and Experiments
Authors: Thompson J. Michael T. 
Published: February 2015

In a recent feature article in this journal, coauthored by Gert van der Heijden, I described the static-dynamic analogy and its role in understanding the localized post-buckling of shell-like structures, looking exclusively at integrable systems. We showed the true significance of the Maxwell energy criterion load in predicting the sudden onset of "shock sensitivity" to lateral disturbances. The present paper extends the survey to cover nonintegrable systems, such as thin compressed shells. These exhibit spatial chaos, generating a multiplicity of localized paths (and escape routes) with complex snaking and laddering phenomena. The final theoretical contribution shows how these concepts relate to the response and energy barriers of an axially compressed cylindrical shell. After surveying NASA's current shell-testing programme, a new nondestructive technique is proposed to estimate the "shock sensitivity" of a laboratory specimen that is in a compressed metastable state before buckling. A probe is used to measure the nonlinear load-deflection characteristic under a rigidly applied lateral displacement. Sensing the passive resisting force, it can be plotted in real time against the displacement, displaying an equilibrium path along which the force rises to a maximum and then decreases to zero: having reached the free state of the shell that forms a mountain-pass in the potential energy. The area under this graph gives the energy barrier against lateral shocks. The test is repeated at different levels of the overall compression. If a symmetry-breaking bifurcation is encountered on the path, computer simulations show how this can be suppressed by a controlled secondary probe tuned to deliver zero force on the shell.
Classification and Synoptic Analysis of Subtropical Cyclones within the Northeastern Atlantic Ocean
Authors: González-Alemán Juan J. , Valero Francisco , Martín-León Francisco , Evans Jenni L. 
Published: February 2015

AbstractSince more research is needed on subtropical cyclones (STCs) formed within the North Atlantic eastern basin, this survey analyzes them from a synoptic point of view, on a climatological basis, with the main aims of studying their common features, complementing other studies of these storms in the North Atlantic, and aiding the forecasting community. Fifteen cases of STCs were identified during the period 1979–2011 by applying a set of criteria from two databases. Composite analysis reveals that an extratropical depression acts as a precursor when it is isolated from the westerlies and then suffers a deepening when becoming subtropical instead of decaying through occlusion. This process is accompanied by an atmospheric circulation, within the North Atlantic, whose main feature is characterized by notable departures from the climatological pattern with a statistically significant anomalous high pressure to the north of the STCs. Three conceptual models of synoptic pattern of subtropical cyclogenesis are derived and show that these departures appeared because the westerly circulation moves poleward and/or the flow has a great meridional component, with the possibility of a blocked flow pattern occurring. Moreover, the identified STCs predominantly formed in a highly sheared (>10 m s−1) environment with low sea surface temperature values (<25°C), which differs from the dominant features of STCs in the North Atlantic, especially within its western region. Finally, a recent (2010) STC, identified by the authors, is synoptically discussed in order to achieve a better interpretation of the general results.
Characteristics of Binary Tropical Cyclones Observed in the Western North Pacific for 62 Years (1951–2012)
Authors: Jang Wook , Chun Hye-Yeong 
Published: February 2015

Abstract
The statistical and dynamical characteristics of binary tropical cyclones (TCs) observed in the western North Pacific (WNP) for 62 years (1951–2012) are investigated by using best track and reanalysis data. A total of 98 binary TCs occurred with an annual average of 1.58. The occurrence frequency of binary TCs shows significant year-to-year variations and there are two peaks in the mid-1960s and early 1990s. Three-fourths (76.3%) of the binary TCs occurred between July and September, which is consistent with the high activity season of TCs in general. A relatively higher track density for binary TCs is present to the east of the maximum track density for total TCs. This result is likely due to the differences in the locations of genesis and environmental steering flow between binary and total TCs. The poleward steering flow, weaker vertical wind shear, and warmer sea surface temperature are pronounced for binary TCs, and these result in a longer lifetime of TCs, which can increase the chances that they would be detected as binary TCs. By applying the clustering analysis technique, six representative trajectories of the binary TCs are obtained. The transitional speed and recurving location are significantly different with respect to the clustered types. The trajectories of each type are strongly related to the temporal variations in the environmental steering flow and the location of the North Pacific high.
Pore-lining sudoite in Rotliegend sandstones from the eastern part of the Southern Permian Basin
Authors: Biernacka J . 
Published: February 2015

AbstractSudoite, an aluminium-rich di-trioctahedral chlorite, is known primarily from highgrade diagenetic/ low-temperature metamorphic Al-rich rocks and from hydrothermal deposits in Alrich terrains. This contribution reports a rare occurrence of pore-lining sudoite in Permian red beds from the eastern part of the Southern Permian Basin. Sudoite is a ubiquitous mineral in aeolian sandstones of the Eastern Erg, a large dune field buried in the subsurface of the Fore-Sudetic Monocline, SW Poland. Sudoite crystals are arranged in a honeycomb texture and often associated with high-porosity intervals. It is concluded that sudoite crystallized at the expense of early diagenetic dioctahedral smectite at a temperature lower than 180°C under the influence of hot, Mgrich and K-poor fluids, which migrated from a basement and/or deep part of the basin upward through permeable aeolian sandstones and mixed with colder pore solutions. Tosudite was a likely intermediate phase in the smectite to sudoite conversion.
Synthesis and optical properties of composites based on ternary Zn1–xCdxS nanoparticles enclosed in a layered octosilicate
Authors: Chen Y. , Yu Z. , Yu G. , Yan Y. 
Published: February 2015

AbstractIn order to improve the optical properties and enhance the stability of Zn1–xCdxS nanoparticles, which are important optoelectrical materials, the ternary Zn1–xCdxS nanoparticles were enclosed in a layered octosilicate by a three-step process, namely (i) protonation of Naoctosilicate, (ii) ion-exchange in order to introduce Zn and Cd ions into the interlayer space, and (iii) addition of S2– to form Zn1–xCdxS particles in the interlayer space of the octosilicate. The basal spacing (~10 Å) of the final ZnCdS-Oct-n (n = 1, 2, 3, 4) composites noticeably increased in comparison with that of the precursor H-Oct (7.5 Å). This may be attributed to the incorporation of larger size Zn1–xCdxS particles into the interlayer space of H-Oct. The UV-visible spectra of the composites suggested that the transmission band-edges gradually shifted to low energy with increasing molar ratio of Cd/Zn. Moreover, the transmission band-edges of the composites are between those of layered Octosilicate, ZnS, and CdS. TEM observation confirmed that the size of Zn1–xCdxS nanoparticles enclosed in the layered silicate was about ~3–5 nm.
Discharge diagnoses versus medical record review in the identification of community-acquired sepsis
Authors: Wang Henry E , Addis Dylan R , Donnelly John P , Shapiro Nathan I , Griffin Russell L , Safford Monika M , Baddley John W 
Published: February 2015

Abstract
Introduction
We evaluated the accuracy of hospital discharge diagnoses in the identification of community-acquired sepsis and severe sepsis.

Methods
We reviewed 379 serious infection hospitalizations from 2003 to 2012 from the national population-based reasons for geographic and racial differences in stroke (REGARDS) cohort. Through manual review of medical records, we defined criterion-standard community-acquired sepsis events as the presence of a serious infection on hospital presentation with ≥2 systemic inflammatory response syndrome criteria. We also defined criterion-standard community-acquired severe sepsis events as sepsis with >1 sequential organ failure assessment organ dysfunction. For the same hospitalizations, we identified sepsis and severe sepsis events indicated by Martin et al. and Angus et al. International Classifications of Diseases 9th edition discharge diagnoses. We evaluated the diagnostic accuracy of the Martin and Angus criteria for detecting criterion-standard community-acquired sepsis and severe sepsis events.

Results
Among the 379 hospitalizations, there were 156 community-acquired sepsis and 122 community-acquired severe sepsis events. Discharge diagnoses identified 55 Martin-sepsis and 89 Angus-severe sepsis events. The accuracy of Martin-sepsis criteria for detecting community-acquired sepsis were: sensitivity 27.6%; specificity 94.6%; positive predictive value (PPV) 78.2%; negative predictive value (NPV) 65.1%. The accuracy of the Angus-severe sepsis criteria for detecting community-acquired severe sepsis were: sensitivity 42.6%; specificity 86.0%; PPV 58.4%; NPV 75.9%. Mortality was higher for Martin-sepsis than community-acquired sepsis (25.5% versus 10.3%, P = 0.006), as well as for Angus-severe sepsis than community-acquired severe sepsis (25.5 versus 11.5%, P = 0.002). Other baseline characteristics were similar between sepsis groups.

Conclusions
Hospital discharge diagnoses show good specificity but poor sensitivity for detecting community-acquired sepsis and severe sepsis. While sharing similar baseline subject characteristics as cases identified by hospital record review, discharge diagnoses selected for higher mortality sepsis and severe sepsis cohorts. The epidemiology of a sepsis population may vary with the methods used for sepsis event identification.
Common 4977 bp deletion and novel alterations in mitochondrial DNA in Vietnamese patients with breast cancer
Authors: Dimberg Jan , Hong Thai Trinh , Nguyen Linh Tu Thi , Skarstedt Marita , Löfgren Sture , Matussek Andreas 
Published: February 2015

Abstract
Mitochondrial DNA (mtDNA) has been proposed to be involved in carcinogenesis and ageing. The mtDNA 4977 bp deletion is one of the most frequently observed mtDNA mutations in human tissues and may play a role in breast cancer (BC). The aim of this study was to investigate the frequency of mtDNA 4977 bp deletion in BC tissue and its association with clinical factors.
We determined the presence of the 4977 bp common deletion in cancer and normal paired tissue samples from 106 Vietnamese patients with BC by sequencing PCR products.
The mtDNA 4977 bp deletion was significantly more frequent in normal tissue in comparison with paired cancer tissue. Moreover, the incidence of the 4977 bp deletion in BC tissue was significantly higher in patients with estrogen receptor (ER) positive as compared with ER negative BC tissue. Preliminary results showed, in cancerous tissue, a significantly higher incidence of novel deletions in the group of patients with lymph node metastasis in comparison with the patients with no lymph node metastasis.
We have found 4977 bp deletion in mtDNA to be a common event in BC and with special reference to ER positive BC. In addition, the novel deletions were shown to be related to lymph node metastasis. Our finding may provide complementary information in prediction of clinical outcome including metastasis, recurrence and survival of patients with BC.
Surgical exploration and discovery program: Inaugural involvement of otolaryngology – head and neck surgery
Authors: Greene Brittany , Head Linden , Gawad Nada , Hamstra Stanley J , McLean Laurie 
Published: February 2015

Background There is significant variability in undergraduate Otolaryngology – Head and Neck Surgery (OTOHNS) curricula across Canadian medical schools. As part of an extracurricular program delivered jointly with other surgical specialties, the Surgical Exploration and Discovery (SEAD) program presents an opportunity for medical students to experience OTOHNS. The purpose of this study is to review the participation and outcome of OTOHNS in the SEAD program. Methods The SEAD program is a two-week, 80-hour, structured curriculum that exposes first-year medical students to nine surgical specialties across three domains: (1) operating room observerships, (2) career discussions with surgeons, and (3) simulation workshops. During observerships students watched or assisted in surgical cases over a 4-hour period. The one-hour career discussion provided a specialty overview and time for students’ questions. The simulation included four stations, each run by a surgeon or resident; students rotated in small groups to each station: epistaxis, peritonsillar abscess, tracheostomy, and ear examination. Participants completed questionnaires before and after the program to evaluate changes in career interests; self-assessment of knowledge and skills was also completed following each simulation. Baseline and final evaluations were compared using the Wilcoxon Signed-Rank test. Results SEAD participants showed significant improvement in knowledge and confidence in surgical skills specific to OTOHNS. The greatest knowledge gain was in ear examination, and greatest gain in confidence was in draining peritonsillar abscesses. The OTOHNS session received a mean rating of 4.8 on a 5-point scale and was the most popular surgical specialty participating in the program. Eight of the 18 participants were interested in OTOHNS as a career at baseline; over the course of the program, two students gained interest and two lost interest in OTOHNS as a potential career path, demonstrating the potential for helping students refine their career choice. Conclusions Participants were able to develop OTOHNS knowledge and surgical skills as well as refine their perspective on OTOHNS as a potential career option. These findings demonstrate the potential benefits of OTOHNS departments/divisions implementing observerships, simulations, and career information sessions in pre-clerkship medical education, either in the context of SEAD or as an independent initiative.
Constructing the social democratic developmental state in Africa: lessons from the “Global South”
Authors: Kieh George Klay 
Published: February 2015

Since the dawn of the post-colonial era in the various regions of the “Global South,” including Africa, the appropriate role of the state in the development process has been a frontier issue. The resulting debate has revolved around two major trajectories: the minimalist state and the maximalist state. The former, shaped by the liberal cum neo-liberal Weltanschauung, posits that the state should have a limited role in socio-economic development—basically the creation of propitious conditions for the private accumulation of capital. Essentially, the suzerainty over the development process should rest with the “market” and its associated forces, particularly businesses. On the other hand, the maximalist state perspective asserts that the state should have a prominent role in the development process, including serving as the engine. Importantly, the debate has gone through various cycles, each dominated by the minimalist state paradigm.In spite of the hegemony of the minimalist state perspective, several states in the “Global South” have experimented with various models of statedirigisme— the “developmental state:” authoritarian (e.g. Singapore and South Korea) and democratic (e.g. Botswana and Mauritius). Against this backdrop, using the lessons learned from the experiences of some of the states in the “Global South” that have experimented with variants of the developmental state model, this article concluded that the social democratic developmental state is the best trajectory for promoting human-centered democracy and development in Africa.