bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blood-based protein biomarkers during the acute ischemic stroke treatment window: a systematic review
Authors: Rahmig Jan , Chanpura Aditya , Schultz Aaliyah , Barone Frank C. , Gustafson Deborah , Baird Alison E. 
Published: July 2024

BackgroundRapid and accurate acute ischemic stroke (AIS) diagnosis is needed to expedite emergent thrombolytic and mechanical thrombectomy treatment. Changes in blood-based protein biomarkers during the first 24 h of AIS, the time window for treatment, could complement imaging techniques and facilitate rapid diagnosis and treatment.MethodsWe performed a systematic review according to PRISMA guidelines. MEDLINE, EMBASE, Cochrane Library, and Web of Science databases were searched for eligible studies comparing levels of blood-based protein biomarkers in AIS patients with levels in healthy controls and stroke mimics. Protein biomarkers from the following pathophysiological categories were included: neurovascular inflammation (MMP-9, TNF-alpha), endothelial integrity (VCAM-1, ICAM-1), cell migration (E-Selectin, P-Selectin, L-Selectin), markers of glial and neuronal origin (GFAP, S100, S100B, NSE), and cardiac dysfunction (BNP, NT-proBNP). The literature search was limited to English-language publications before November 7th, 2023.ResultsA total of 61 studies from 20 different countries were identified, which included in total, 4,644 AIS patients, 2,242 stroke mimics, and 2,777 controls. Studies investigating TNF-alpha, MMP-9, VCAM-1, ICAM-1, E-Selectin, L-Selectin, GFAP, NSE, and S100B showed pronounced methodological heterogeneity, making between-study comparisons difficult. However, in 80% of NT-proBNP and BNP studies, and all P-selectin studies, higher biomarker levels were observed in AIS patients compared to healthy controls and/or patients with stroke mimics.ConclusionNone of the biomarkers included showed sufficient evidence for additional diagnostic benefit for AIS. Comprehensive standardized global multicenter studies are needed to (1) permit comparability, (2) enable valid statements about protein-based biomarkers, and (3) reflect real-world scenarios.
VKH-like uveitis during donafenib therapy for hepatocellular carcinoma: a case report and review of the literature
Authors: Liu Rui , Liu Guina , Lu Fang 
Published: July 2024

BackgroundThe incidence of uveitis has risen with the use of targeted therapies, particularly prevalent in the administration of immune checkpoint inhibitors and MAP-kinase pathway inhibitors. We report the first case of VKH-like uveitis linked to Donafenib employed for the primary hepatocellular carcinoma, highlighting the necessity of ophthalmological follow-up in patients undergoing treatment with Donafenib.Case presentationA 55-year-old man developed VKH-like symptoms, including sporadic white patches, tinnitus, headache, and mild bilateral vision reduction, after 18 months of treatment with Donafenib and Sintilimab for hepatocellular carcinoma. Based on ophthalmological examinations that fundus fluorescein angiography images demonstrating multiple focal areas of pinpoint hyperfluorescence, along with pooling indicative of neurosensory detachment and disc leakage in both eyes, choroid thickening in swept-source optical coherence tomography, and “sunset-glow” fundus appearance, a tentative diagnosis of VKH-like uveitis was made. Initially, his best-corrected visual acuity (BCVA) was 20/200 in the right eye and 20/80 in the left eye. Upon discontinuing Donafenib and starting a 3-month course of oral glucocorticoids, his BCVA improved to 20/30 in the right eye and 20/40 in the left eye.ConclusionTargeted drugs have been commonly used for cancer treatment in recent years, but challenges of ocular side effects emerged gradually. To optimize patient outcomes, regular ophthalmological follow-ups are essential for those undergoing treatment with targeted therapies like Donafenib.
Ophiopogonin D: review of pharmacological activity
Authors: Chen Ke-qian , Wang Shu-zhi , Lei Hai-bo , Liu Xiang 
Published: July 2024

BackgroundOphiopogon D is an important natural organic compound in Ophiopogon japonicus, which often has significant biological activity.PurposeThe purpose of this review is to systemically summarize and discuss the pharmacological activity and underlying mechanisms of OP-D in recent years.MethodPubMed and Web of Science were searched with the keywords:“Ophiopogon japonicus”, “Ophiopogon D” “pharmacology”, and “pharmacokinetics”. There was no restriction on the publication year, and the last search was conducted on 1 Jan 2024.ResultsEmerging evidence suggests that OP-D possess numerous pharmacological activities, including bone protection, cardiovascular protection, immune regulation, anti-cancer, anti-atherosclerosis, anti-inflammatory and anti-NAFLD.ConclusionOP-D has a potential value in the prevention and treatment of many diseases. We hope that this review will contribute to therapeutic development and future studies of OP-D.
An anatomical study of the subarachnoid space surrounding the trigeminal ganglion in horses—in preparation for a controlled glycerol rhizotomy in equids
Authors: Becker Richard , Haenssgen Kati , Precht Christina , Khoma Oleksiy-Zakhar , Hlushchuk Ruslan , Koch Christoph , Kaessmeyer Sabine , de Preux Mathieu 
Published: July 2024

IntroductionEquine trigeminal-mediated headshaking is a painful neuropathic disorder comparable to trigeminal neuralgia in humans. The selective destruction of pain fibers within the trigeminal ganglion, called rhizotomy, is the surgical treatment of choice for idiopathic trigeminal neuralgia refractory to medical treatment in humans. The human trigeminal ganglion is enclosed by a dural recess called the Meckel’s or trigeminal cave, in which the ganglion is surrounded by a cerebrospinal fluid (CSF)-filled subarachnoid space. During glycerol rhizotomy, glycerol is percutaneously injected in this CSF-filled space. Until now, information about the anatomy of the dural recess and the subarachnoid space surrounding the trigeminal ganglion is lacking in horses. The aim of this study was to explore if a CSF-filled subarachnoid space around the trigeminal ganglion exists in horses.Materials and methodsSix equine cadaver heads were investigated for CSF accumulation around the ganglion with a 3 Tesla MRI. After anatomical dissection to expose the trigeminal root, a polymer-based radiopaque contrast agent was injected through the porus trigeminus into the subarachnoid space (cisternography). The exact delineation and the volume of the contrast agent accumulation were determined on subsequent micro-computed tomographic scans and segmentation. Finally, the distribution of the contrast agent within the subarachnoid space was examined histologically in three specimens.ResultsIn all 12 specimens included in this study, the trigeminal ganglion was surrounded by a subarachnoid space forming a trigeminal cistern. The mean volume of the trigeminal cave in this study was 0.31 mL (±SD: 0.11 mL). Distribution of the contrast agent along the peripheral nerves (i.e., ophthalmic, maxillary and/or mandibular nerve) was observed in 7 out of 12 specimens.Discussion/conclusionA subarachnoid space surrounding the trigeminal ganglion exists in the horse and could be targeted for glycerol rhizotomy in horses suffering from trigeminal-mediated headshaking. However, the clinical relevance of contrast agent distribution along the peripheral nerves remains to be assessed.
Ruthenium(II) Complex-Based Tetradentate Schiff Bases: Synthesis, Spectroscopic, Antioxidant, and Antibacterial Investigations
Authors: Es-Sounni Bouchra , Harboul Kaoutar , Mouhib Ayoub , Alanazi Ashwag S. , Hefnawy Mohamed , Bakhouch Mohamed , Benali Taoufiq , Hammani Khalil , Mazoir Noureddine , El Yazidi Mohamed , Benharref Ahmed , Fahim Mohammed 
Published: July 2024

In this work, we describe the synthesis of novel Ruthenium (II) complex-based salen Schiff bases. The obtained Ruthenium (II) complexes are characterized using usual spectroscopic and spectrometric techniques, viz., IR, UV-Vis, NMR (1H and 13C), powder X-ray diffraction, and HRMS. Further techniques, such as DTA-TGA and elemental analysis, are used to well establish the structure of the obtained complexes. Octahedral geometries are tentatively proposed for the new Ru(II) complexes. The measured molar conductance for the Ruthenium (II) complexes shows their electrolytic nature (4.24–4.44 S/m). The new Ru(II) complexes are evaluated for their antioxidant and antibacterial activities. The DPPH radical scavenging, FRAP, and total antioxidant capacity (TAC) assays show that the obtained complexes are more potent than the used positive control. They also exhibit promising antibacterial responses against pathogen bacteria: [RuH2L3Cl2] exhibits an important inhibition against Bacillus subtilis DSM 6633, with an inhibition zone of 21 ± 1.41 mm with an MIC value of 0.39 mg/mL, and Proteus mirabilis INH, with 16.50 ± 0.70 mm and an MIC value of 0.78 mg/mL, while [RuH2L2Cl2] exerts interesting antibacterial effects versus Bacillus subtilis DSM 6633 (21 ± 1.41 mm) and Proteus mirabilis INH (25.5 ± 0.70 mm) with equal MIC values of 0.97 mg/mL.
Лінійні ігрові задачі з інтегральними обмеженнями на керування
Authors: Бєлоусов Андрій Олександрович , Чикрій Аркадій Олексійович , Корнюш Ірина Інокентіївна , Петрик Олена Семенівна 
Published: July 2024

Разом з прямими методами Л.С. Понтрягіна, правилом екстремального прицілювання М.М. Красовського, методом Гамільтона–Якобі–Беллмана–Ай­зекса (ГЯБА) в теорії динамічних ігор ефективним для досліджень є метод розв’язуючих функцій. Останній має широке коло застосувань, включаючи задачі з групами учасників (переслідувачів та втікачів) та процеси зі складною динамікою (рівняння в частинних похідних та з дробовими похідними різних типів). У статті розглядаються лінійні конфліктно-керовані процеси з інтегральними обмеженнями на керування. В основу досліджень покладено ідеї методу розв’язуючих функцій з використанням накопичувального принципу при побудові вищезгаданих скалярних функцій, які визначають момент виведення траєкторії системи на термінальну множину. Вважається виконаною певна умова переваги переслідувача над втікачем за ресурсами керування — аналог умови Понтрягіна, яка надає можливість будувати гарантовані керування переслідувача (вимірні функції) на основі теореми Філіпова–Кастена про вимірний вибір на активному та пасивному проміжках у процесі гри. З використанням техніки багатозначних відображень вивчено властивості розв’язуючих функцій та встановлено достатні умови завершення диференціальної гри. Теоретичні результати ілюструються на модельному прикладі з простими рухами гравців та контрольному прикладі Понтрягіна. Вказана можливість перенесення викладених результатів на випадок більш складних інтегральних обмежень на керування.
Avalanche disaster review in Turkey
Authors: Гурер И. 
Published: July 2024

Одним из стихийных бедствий, встречающихся в основном на склонах и в весенний период, в горных районах и высокогорных плоскогорьях Турции, в Центральной и Восточной Анатолии, являются лавины. Особенно в сильноснежных районах Восточной Анатолии люди, живущие в деревнях, удаленных от городских центров, лишаются жизни и домов, дороги перекрываются. Энергетические опоры и линии электропередач разрушаются из-за сильного снежного покрова и схода лавин. Во время метелей чрезмерное скопление снега на плоских и земляных крышах, обледенение карнизов отрицательно сказываются на условиях жизни людей. Ежегодно около 25 человек погибает в результате схода лавин в городских районах, очень мало в местах зимнего туризма, а потери имущества точно не известны. В этом исследовании иллюстрируется нынешняя ситуация с территориальным распространением лавин, их распределение во времени и, в этом контексте, недавние исследования по картированию лавин, моделированию, которые были выполнены до сих пор. На основании имеющихся данных выделены лавиноопасные зоны в Турции, дан анализ лавинных данных за период с 1950 по 2019 год. Определены структурные и неструктурные меры, необходимые для борьбы с лавинной проблемой. Обсуждаются мнения о необходимости координации деятельности государственных структур по предотвращению схода лавин.
One of the natural disasters encountered mostly on barren slopes and in the spring season, in the mountainous parts and high plateaus of Turkey, in Central and Eastern Anatolia, is avalanche. Especially in heavy snow areas of the Eastern Anatolia, people living in villages and hamlets far from the city centers, lose their lives and homes, roads are closed. Energy pilons and energy transmission lines are destroyed due to heavy snow accumulation and avalanches. During snow storms, excessive snow accumulation on flat and earthen roofs, and icing on eaves adversly affect the living conditions of people. Every year, about 25 people lives are lost in avalanche accidents in urban areas, very few at winter tourism locations, and the loss of property is not clearly known. In this study, the present situation of the areal distribution of avalanche events, their distribution in time, and in this context, the recent avalanche mapping, modelling and simulation studies that have been done so far are exemplified. Based on the data available, avalanche-hazardous zones in Turkey are identified, the analysis of avalanche data for the period 1950–2019 is given. The structural and non-structural measures necessary to control the avalanche problem are defined. Opinions are shared on the necessity of coordination among the state institutions working on avalanche disaster prevention.
On the issue of the factors of the collapse of the Kolka Glacier in 2002
Authors: Барановский А.Ф. , Запорожченко Э.В. 
Published: July 2024

Выполнен анализ факторов, которые могли оказать влияние на катастрофическое развитие событий при сходе ледника Колка 20 сентября 2002 г. Основываясь на материалах многочисленных публикаций и приведенных в статье новых данных, авторы предлагают свою оценку и интерпретацию некоторых особенностей эндогенных и экзогенных процессов, происходивших в ущелье Колка. Выделены гравитационно-тектонические блоки в скальном массиве на правобережном склоне ледникового цирка Колка, к которым приурочены крупные обвалы льда и горных пород, наблюдавшиеся в 2002 г. Приведены доказательства эндогенной активности в долине р. Колка. Прослежены две системы разрывных нарушений, к пересечению которых приурочен участок проявления газовых извержений в днище ледникового цирка Колка. Установлено, что причиной формирования катастрофической ледово-каменной лавины в 2002 г. являются эндогенные факторы, а именно, взрыв газов и пара в тыловой части ледника Колка.
The analysis of factors that could have influenced the catastrophic development of events during the descent of the Kolka glacier on September 20, 2002 was carried out. Based on numerous publications and the new data presented in the article, the authors offer their assessment and interpretation of some features of endogenous and exogenous processes occuring in the Kolka Gorge. Gravitational-tectonic blocks in the rock massif on the right-bank slope of the Kolka glacier cirque have been identified, which are associated with large collapses of ice and rocks observed in 2002. The evidence of endogenous activity in the Kolka River valley is presented. Two systems of discontinuous faults have been traced, the intersection of which is associated with the site of the manifestation of gas eruptions in the bottom of the Kolka glacier cirque. It has been established that the cause of the formation of a catastrophic ice-stone avalanche in 2002 is endogenous factors, namely, the explosion of gases and steam in the rear part of the Kolka glacier.
ALLUVIAL FACIES IN THE UPPER NEOPLEISTOCENE DEPOSITS OF THE KIRYAS SECTION
Authors: Коркин С.Е. , Коркина Е.А. 
Published: July 2024

В данной работе, представлены новые результаты геохронометрических данных, полученные на основе изучения геолого-геоморфологического разреза «Кирьяс К». Обнажение Юганско-Ларъёганской возвышенной террасы, относится к долине р. Обь, расположено к северу от 60°50′ с.ш. Разрез вскрывает аллювиальные фации палеорусла Оби, которые сверху перекрыты лессово-почвенными комплексами. Методами датирования проб: OSL и C 14 было определено, что аллювиальные отложения относятся к Кирьяским стадиям позднеплейстоценового времени на уровне МИС 5e, d. Их перекрывают палеопочвенные комплексы, представленные перегнойно-глеевой палеопочвой, с водно-аккумулятивными признаками и серо-гумусово-глеевой палеопочвой с криогенными признаками. Палеопочвы относятся к каргинской стадии и синхронизируются со стадией неоплейстоцена МИС 3.
This article presents new results of geochronometric indicators, which were obtained during the study of the geological and geomorphological rock outcrop "Kiryas K." The Yugan-Laryogan elevated terrace is located north of 60° 50′ N and belongs to the valley of the Ob River. The geological rock outcrop in the lower part is penetrated by the alluvial facies of the Ob paleo-riverbed rhound, which are overlain by loess-soil complexes from above. The Kiryan stage of late Pleistocene time at the level of MIS 5e, d and MIS 3 were determined by methods of age determination: OSL and radiocarbon. The alluvial sediments are overlain by paleosteal complexes, which are represented by humus-gley paleosteum, with water-accumulative features and gray-humus-gley paleosteum with cryogenic features. Paleo-soils belong to the Kargin stage and synchronize with the Neopleistocene stage.
DYNAMICS OF DOWNCUTTING AND ACCUMULATION IN RIVER VALLEYS OF THE VOLGA BASIN DURING THE LATE PLENIGLACIAL
Authors: Украинцев В.Ю. , Захаров А.Л. 
Published: July 2024

Большие палеорусла – сохранившиеся в рельефе речных пойм древние речные русла, размеры которых значительно превышают размеры современных русел тех же рек. Их параметры и морфология указывают на то, что они формировались при увеличенном речном стоке. Большие палеорусла бассейна Волги могли играть ключевую роль в динамике береговой линии Каспийского моря. Произведено бурение и изучение строения больших палеорусел в разных частях бассейна Волги. Русловую фацию аллювия больших палеорусел подстилают мощные пачки отложений, заполняющих глубокие врезы. Датирование этих отложений показало, что в средневалдайскую эпоху реки были врезаны на значительную глубину, а в её конце и в первую половину поздневалдайского времени в речных долинах происходило заполнение этих врезов. По данным геодезической съёмки установлены отметки высоты кровли современного и поздневалдайского руслового аллювия. Хотя в течение эпохи формирования больших палеорусел реки бассейна должны были испытывать врезание вследствие роста стока воды, часто кровля руслового аллювия больших палеорусел расположена выше кровли современного руслового аллювия, формирующегося при более низком речном стоке. Это объясняется тем, что современные реки унаследовали профили дна долин от поздневалдайских; по окончании эпохи обильного стока лишь у части рек произошла адаптация продольных профилей к уменьшившимся величинам стока.
Large paleochannels are ancient river channels preserved in the landscape of river floodplains, the dimensions of which significantly exceed the proportions of modern channels of the same rivers. Their parameters and morphology indicate that they were formed during periods of heightened water runoff. The large paleochannels of the Volga basin may have significant implications for the dynamics of the Caspian shoreline in past. This paper presents results of the drilling, dating, and study of the large paleochannels in different parts within the Volga basin. The channel alluvium of large paleochannels is underlain by thick units of sediments filling deep incisions. Dating of these deposits showed that in the Middle Weichselian time, river valleys were deep-incisioned, and at the end of this epoch and in the first half of the Late Weichselian time, these deep incisions were filled. According to geodetic survey data, the true altitude of modern and ancient alluvium tops was established. Although during the formation of large paleochannels, the rivers of the Volga basin must have incised due to increased runoff, often the top of the channel alluvium of large paleochannels is located above the top of the modern channel alluvium, which formed at the lower runoff volume. This is explained by the fact that modern rivers inherited the grade lines from the late Weichselian ones; at the end of the epoch with high fluvial activity, only a part of the rivers adapted their grade to decreased runoff.
LEGAL AND MANAGEMENT ASPECTS OF THE FORMATION OF SOVIET STATEHOOD
Authors: ПЛОТНИКОВА Е.В. , БАТ З.А. , ГАСАНОВА А.А. 
Published: July 2024

В работе рассмотрен период социалистической революции 1917 года, характеризующийся зарождением советской бюрократии.
The period of socialist revolution of 1917 which is characterized by the emergence of the Soviet bureaucracy is studied in this work.
BUDGET RISK MANAGEMENT
Authors: ЧИСТЯКОВА М.К. , ШМИДТ Ю.И. 
Published: July 2024

В статье рассмотрены проблемы управления бюджетными рисками на уровне бюджетов субъектов России. Выявлено, что невыполнение бюджетов по доходам наблюдается более сильное, чем невыполнение по расходам. Сделан вывод о необходимости разработки единых подходов к формированию резервных фондов субъектов РФ, как элемента управления бюджетными рисками.
The article deals with the problems of budget risk management at the level of budgets of the subjects of Russia. It was revealed that the non-fulfillment of budgets by income is stronger than the non-fulfillment by expenses. It is concluded that it is necessary to develop unified approaches to the formation of reserve funds of the subjects of the Russian Federation as an element of budget risk management.
Biophysics Concept Inventory Survey: An Assessment in Biophysical Undergraduate Education
Authors: Latham Danielle R. , Alper Joshua D. , Sanabria Hugo 
Published: July 2024

ABSTRACT
Since the Force Concept Inventory in 1992, many concept inventories have been developed to cover classical scientific fields. However, there is a lack of concept inventories for interdisciplinary fields, such as biophysics. We introduce a Biophysics Concept Inventory Survey (BCIS), a 20-question, multiple-choice survey to measure student gains in biophysical concepts. The BCIS contains 5 question classifications: remember, understand, apply, analyze, and create, as well as question concepts divided into primarily physics or primarily biology questions. We administered the BCIS to 3 cohorts of students over 4 years. Each cohort participated in a 10-week summer Research Experience for Undergraduates (REU) in biophysics. We compared the presurvey (before REU) and postsurvey (after REU) scores to determine the fraction of the maximum possible gain or loss realized. Our analysis of the results suggests that the BCIS shows no biases based on sex or ethnicity. Further, we used the BCIS to show that 69% of the REU participants showed gains in biophysics concepts, with most of the total participant mean of gain occurring at higher levels of Bloom’s taxonomy: create and analyze. Overall, participants obtain slightly higher scores in physics (8% increase) than biology (5% increase) when comparing the pre- and postscores. The coronavirus disease 2019 pandemic allows a splitting of prepandemic and postpandemic cohorts, with the postpandemic cohort showing significantly larger gains than the prepandemic students. These results show that the BCIS, with question classifications and concepts, probes the students’ ability to apply knowledge to various biophysical science topics without underlying biases and enables instructors to obtain answers to important questions about the effectiveness of the educational programs. The BCIS fills a gap for interdisciplinary concept inventories.