bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unified tests for fine-scale mapping and identifying sparse high-dimensional sequence associations
Authors: Cao Shaolong , Qin Huaizhen , Gossmann Alexej , Deng Hong-Wen , Wang Yu-Ping 
Published: October 2015

AbstractMotivation: In searching for genetic variants for complex diseases with deep sequencing data, genomic marker sets of high-dimensional genotypic data and sparse functional variants are quite common. Existing sequence association tests are incapable of identifying such marker sets or individual causal loci, although they appeared powerful to identify small marker sets with dense functional variants. In sequence association studies of admixed individuals, cryptic relatedness and population structure are known to confound the association analyses.Method: We here propose a unified marker wise test (uFineMap) to accurately localize causal loci and a unified high-dimensional set based test (uHDSet) to identify high-dimensional sparse associations in deep sequencing genomic data of multi-ethnic individuals with random relatedness. These two novel tests are based on scaled sparse linear mixed regressions with Lp (0 &lt; p &lt; 1) norm regularization. They jointly adjust for cryptic relatedness, population structure and other confounders to prevent false discoveries and improve statistical power for identifying promising individual markers and marker sets that harbor functional genetic variants of a complex trait.Results: With large scale simulation data and real data analyses, the proposed tests appropriately controlled Type I error rates and appeared to be more powerful than several prominent methods. We illustrated their practical utilities by the applications to DNA sequence data of Framingham Heart Study for osteoporosis. The proposed tests identified 11 novel significant genes that were missed by the prominent famSKAT and GEMMA. In particular, four out of six most significant pathways identified by the uHDSet but missed by famSKAT have been reported to be related to BMD or osteoporosis in the literature.Availability and implementation: The computational toolkit is available for academic use: https://sites.google.com/site/shaolongscode/home/uhdsetContact: wyp@tulane.eduSupplementary information: Supplementary data are available at Bioinformatics online.
Seizures and cancer: drug interactions of anticonvulsants with chemotherapeutic agents, tyrosine kinase inhibitors and glucocorticoids
Authors: Bénit Christa P. , Vecht Charles J. 
Published: October 2015

AbstractPatients with cancer commonly experience seizures. Combined therapy with anticonvulsant drugs (AEDs) and chemotherapeutic drugs or tyrosine kinase inhibitors carries inherent risks on drug-drug interactions (DDIs). In this review, pharmacokinetic studies of AEDs with chemotherapeutic drugs, tyrosine kinase inhibitors, and glucocorticoids are discussed, including data on maximum tolerated dose, drug clearance, elimination half-life, and organ exposure. Enzyme-inducing AEDs (EIAEDs) cause about a 2-fold to 3-fold faster clearance of concurrent chemotherapeutic drugs metabolized along the same pathway, including cyclophosphamide, irinotecan, paclitaxel, and teniposide, and up to 4-fold faster clearance with the tyrosine kinase inhibitors crizotinib, dasatinib, imatinib, and lapatinib. The use of tyrosine kinase inhibitors, particularly imatinib and crizotinib, may lead to enzyme inhibition of concurrent therapy. Many of the newer generation AEDs do not induce or inhibit drug metabolism, but they can alter enzyme activity by other drugs including AEDs, chemotherapeutics and tyrosine kinase inhibitors. Glucocorticoids can both induce and undergo metabolic change. Quantitative data on changes in drug metabolism help to apply the appropriate dose regimens. Because the large individual variability in metabolic activity increases the risks for undertreatment and/or toxicity, we advocate routine plasma drug monitoring. There are insufficient data available on the effects of tyrosine kinase inhibitors on AED metabolism.
New identification of the mixed-morphology supernova remnant G298.6−0.0 with possible gamma-ray association
Authors: Bamba Aya , Sawada Makoto , Nakano Yuto , Terada Yukikatsu , Hewitt John , Petre Robert , Angelini Lorella 
Published: October 2015

Abstract
We present an X-ray analysis on the Galactic supernova remnant (SNR) G298.6−0.0 observed with Suzaku. The X-ray image shows a center-filled structure inside a radio shell, implying that this SNR can be categorized as a mixed-morphology (MM) SNR. The spectrum is well reproduced by a single-temperature plasma model in ionization equilibrium, with a temperature of 0.78 (0.70–0.87) keV. The total plasma mass of 30 M⊙ indicates that the plasma has an interstellar medium origin. The association with a GeV gamma-ray source, 3FGL J1214.0−6236, on the shell of the SNR is discussed, in comparison with other MM SNRs with GeV gamma-ray associations. It is found that the flux ratio between absorption-corrected thermal X-rays and GeV gamma-rays decreases as the physical size of MM SNRs becomes larger. The absorption-corrected thermal X-ray flux of G298.6−0.0 and the GeV gamma-ray flux of 3FGL J1214.0−6236 closely follow this trend, implying that 3FGL J1214.0−6236 is likely to be a GeV counterpart of G298.6−0.0.
Competitiveness: from a misleading concept to a strategy supporting Beyond GDP goals
Authors: Aiginger Karl , Vogel Johanna 
Published: October 2015

Purpose– This paper aims to show how the term competitiveness has been applied and adapted since Michael Porter made it respectable in economics, strategic management and consulting. This paper connects the concept with new developments in the theory of the firm, theories of growth and, finally, with Beyond GDP literature.Design/methodology/approach– This paper distinguishes between input and output competitiveness, developing a set of indictors for both. Countries are ranked according to costs, structure and capabilities (drivers of competitiveness) as well as according to economic, social and ecological performance (performance pillars). Finally, outcome competitiveness is explained by the individual drivers, using econometrics and principal component analyses.Practical implications– Defining competitiveness as the ability of a country or nation to deliver Beyond GDP goals changes the policy conclusions drawn from the quest for competitiveness. Policies to reduce costs prove inferior relative to “high-road strategies” built on skills, innovation and supporting institutions. Ecological ambition and social investment are not costs, but enablers of competitiveness for high-income countries.Originality/value– Connecting the well-known term competitiveness with Beyond GDP goals is a new approach. It is very different from the old concept of cost competitiveness criticized heavily by Paul Krugman. Supplying a set of indicators to measure “low-road” and “high-road” competitiveness leads to important new policy conclusions.
Threat orientation in small and medium-sized enterprises
Authors: Herbane Brahim 
Published: October 2015

Purpose– The purpose of this paper is to examine whether the experience, impact and likelihood of an acute business interruption, along with the perceived ability to intervene, influences the “threat orientation” of owner-managers in small- and medium-sized enterprises (SMEs) in the UK. The concept of “threat orientation” is introduced in this study as a way to eschew the binary view of whether an organisation does or does not have processes and capabilities to respond to acute interruptions.Design/methodology/approach– “Threat orientation” is operationalised and survey data are collected from 215 SMEs in the UK. Data from owner-managers are analysed using multiple regression techniques.Findings– The results of this study provide empirical evidence to highlight the importance of firm age rather than size as a determinant of the propensity to formalise activities to deal with acute interruptions. Recent experience and the ability to intervene were statistically significant predictors of threat orientation but the likelihood and concern about specific types of threat was not found to positively influence threat orientation.Research limitations/implications– Although the data are self-report in nature, the respondents in the study are the chief decision and policy makers in their organisations and thus it is essential to understand the influences on their threat orientation. Results are generalisable only to UK SMEs.Originality/value– The findings of the paper contribute to a nascent understanding of planning for acute interruptions in SMEs and (despite the cross-sectional nature of the study), the findings clearly reinforce the need for continuing longitudinal research into how resilience develops in smaller organisations.
Identity change in organizations: a philosophical exposition
Authors: Koskinen Kaj Untamo 
Published: October 2015

Purpose– This paper aims to describe how organization’s identity changes in the course of time. Focus is on project-based companies.Design/methodology/approach– The paper first highlights the concept of process thinking. Then follow descriptions of notions of identity and identity change as change processes. After that, three different identity change processes – negotiation of meaning, lauguaging and interaction – are illustrated. And after that follows the main content of the paper, namely, descriptions of identity changes in organizations. These descriptions focus on two approaches: “Unintentional identity change” and “Intentional identity change”.Findings– Identity provides organizations with powerful understanding of theories of who they are. These understandings guide subsequent resource allocation decisions. Identity change in an organization can be categorized into unintentional and intentional identity changes. Unintentional identity changes takes place through the previously mentioned three processes. Instead, intentional identity change takes place through strategy planning.Practical implications– Finding a viable view through which organizations can understand how their identities chance in the course of time is a very important issue. Therefore, in this paper, the authors have sought to offer a brief illustration of this area.Originality/value– In the literature, rather, a lot of attention has been focused on how identities are constructed, and what is their role, for example, in the companies’ strategic management and marketing. However, less attention has been paid to how identities are involved in organizations’ change processes. That is why the goal of this paper is to address that lack by studying identity change in organizations.
Enacting change through borrowed legitimacy: an institutional perspective
Authors: Mattingly Eric Shaunn , Westover Jonathan H. 
Published: October 2015

Purpose– This paper aims to offer borrowed legitimacy through coalitions as an explanation for how an organization might successfully deviate from social norms to enact change, yet still gain sufficient cognitive and sociopolitical legitimacy for survival. This paper explains that borrowing legitimacy through a coalition allows an illegitimate organization to impose an alternative future despite institutional pressures for its convergence to social norms, rules and expectations.Design/methodology/approach– To explore the ability of an organization that lacks legitimacy to borrow legitimacy through a coalition, the authors use a case study and content analysis of interviews, news articles and other publicly available secondary data to examine an environmentalist organization, Sea Shepherds, who openly seek legitimacy and resources, and are engaged in enacting change while using a unique or alternative form.Findings– The case study here shows how a coalition with another organization that already has legitimacy can help the reference organization gain legitimacy themselves by borrowing legitimacy initially. Specifically, because more constituents are aware of the organization with existing legitimacy, the coalition allows the reference organization to borrow that cognitive legitimacy and constituents become aware of the reference organization as well.Research limitations/implications– Although this study provides meaningful insights to the phenomena at hand, it is limited in method and scope. As noted by Zucker, the institutional environment is very important to organization form and likelihood of success (Zucker, 1987); however, this paper does not include a parameter that recognizes the environment specifically. Instead, the model includes a parameter, p, to acknowledge that there are exogenous factors that affect the likelihood of a successful outcome that are not considered individually in the model. Also, this study does not empirically test specific hypotheses using a generalizable sample.Originality/value– This paper contributes to institutional theory by providing a case study of an organization that is enacting change in lieu of the forces that promote institutionalization. The reference organization in the case study demonstrates one form of entrepreneurial organization that successfully deviates from social norms to enact change, yet still gains cognitive and sociopolitical legitimacy. The case study in this paper contributes by providing an example of an organizational form that allows a seemingly illegitimate organization to envision and impose an alternative future despite institutional pressures by forming a coalition with an actor that already has legitimacy.
The connection between organizational climate and well-being at work
Authors: Viitala Riitta , Tanskanen Jussi , Säntti Risto 
Published: October 2015

Purpose– The purpose of this paper is to examine the connections between organizational climate and well-being at work.Design/methodology/approach– Connections between perceived organizational climate and well-being at work were studied through quantitative data gathered from 24 public day-care centers in Finland.Findings– The unit-level analyses revealed that different types of organizational climates were connected to different types of job well-being in the unit. Organizational climate types were differentially connected to stress and cynicism, but were not connected to work engagement. Employees in units where work climate was collectively evaluated as particularly weak reported significantly lower well-being than those in units with better work climate. The most positive climates – “relaxed and friendly” and “encouraging and supportive of new ideas” – seemed to be more strongly connected to well-being than negative climates.Originality/value– The study confirmed and clarified the link between organizational climate and job well-being and emphasized how different climate types have varying types of connection to well-being at work.
Negotiating organizational future: symbolic struggles in a fiscal crisis
Authors: Schaefer Zachary A. , Lynch Owen H. 
Published: October 2015

Purpose– The authors use concepts from the “communication constitutes organizations” (CCO) literature in combination with Cooren’s (2010, 2012) ventriloquism to demonstrate the symbolic uses of texts and shifting interpretations of authority during a negotiation regarding the future of a nonprofit educational institution. The two sides negotiating over how to resolve a fiscal crisis struggled to achieve legitimacy through competing institutional logics, and this paper captures this process through a detailed account. The paper aims to discuss these issues.Design/methodology/approach– This study emerged from a multi-year full immersion ethnography undertaken by the second author, who spent over 5,000 hours as a participant observer at the organization. The quotes and observations come form field notes taken during this time.Findings– Communication constitutes the nonprofit institution through two communication flows – self-structuring processes and institutional positioning – and these flows symbolically and materially unified the opposing negotiation parties during the negotiation process as each side struggled to gain legitimacy through competing institutional logics. The process of ventriloquism was the mechanism through which different actors and texts negotiated their levels of authority.Practical implications– This case demonstrates how oppositional groups used and viewed texts throughout a negotiation process, revealing the agency, authority, legitimacy, and symbolic power of texts. This case also highlights the political struggle between institutional logics backed by financial models and professional logics backed by traditional organizational values.Originality/value– At a material level, this case is a detailed examination of organizational members navigating the negotiation process during a fiscal crisis, but on a symbolic level this case demonstrates the communicative means through which oppositional groups negotiate core organizational values, and whether past values can lead organizations to a sustainable future. The observational depth of this case study was only possible through long term, full immersion ethnography, and this depth provides clarity to abstract concepts from CCO, ventriloquism, and institutional theory.
Exploring the role of personality traits in followee recommendation
Authors: Tommasel Antonela , Corbellini Alejandro , Godoy Daniela , Schiaffino Silvia 
Published: October 2015

Purpose– Followee recommendation is a problem rapidly gaining importance in Twitter as well as in other micro-blogging communities. To find interesting users to follow, most recommendation systems leverage different factors such as graph topology or user-generated content, among others. Those systems mostly disregard, however, the effect of psychological characteristics, such as personality, over the followee selection process. As personality is considered one of the primary factors that influence human behaviour, the purpose of this paper is to shed some light on the impact of personality traits on followee selection.Design/methodology/approach– The authors performed a data analysis comparing the similarity among Twitter users and their followees regarding personality traits. The authors analysed three different similarity measures. First, the authors computed an overall similarity considering the five personality traits or dimensions of the Five-Factor model as a whole. Second, the authors computed the dimension-to-dimension similarity considering each individual personality trait independently of each other. Third, the authors computed a cross-dimension similarity considering each personality dimension in relation to the others.Findings– This study showed that personality should be considered as a distinctive factor in the process of followee selection. However, personality dimensions should not be analysed as a whole as the overall personality similarity might not accurately assess the actual matching between individuals. Instead, the performed data analysis showed the existence of relations among the individual dimensions. Thus, the importance of considering each personality trait with respect to others is stated.Originality/value– This study is among the firsts to study the impact of personality, one of the primary factors that influence human behaviour and social relationships, in the selection of followees in micro-blogging communities.
What Do Young People Think About the CAP? An Experiment
Authors: Azcárate Tomás García , Terrile Daniela 
Published: October 2015

SummaryThe new Commission wants to close the gap between Europe and the citizens. We bring to the debate on the future of the Common Agricultural Policy the results of our experiment with three different groups of young people in Brussels and Paris. They were asked to identify and classify the main five achievements and weaknesses of the CAP and to provide another five recommendations to European politicians. Despite the differences between the groups, we observed important convergences on what was the most positive aspect, namely, a common policy which has provided self‐sufficiency in Europe. The most negative opinion concerned a policy which is not targeted at those most in need. In terms of recommended changes, the groups thought that the CAP should be more environmentally friendly, sustainable and democratic; and there was also a need for a rebalancing of the food chain in order to achieve a better distribution of value added within the chain. Surprisingly, some issues that are usually popular in the Anglo‐Saxon world, such as the budgetary cost of the CAP or the need for more subsidiarity and fewer Brussels‐driven instructions, were only marginally present in the debate.
DNA barcode library and its efficacy for identifying food‐associated insect pests in Korea
Authors: Cho Seo Young , Suh Kyong In , Bae Yeon Jae 
Published: October 2015

AbstractFood‐associated insect pests are of great economic and hygienic importance. However, their identification requires expert knowledge and excessive time. Such pests are discovered in food as body parts or immature stages, which further complicates the identification process. In this study, we constructed a DNA barcode dataset of insect pests that can be detected in food. We also tested the efficacy of these DNA barcode sequences for identifying food‐associated insect pests. A 658 bp fragment of the mitochondrial cytochrome c oxidase subunit I (COI) gene was analyzed from 55 species of food‐associated insect pests in Korea. The results indicated that this portion of the COI gene effectively discriminated >90% of the food‐associated insect pests. Mean genetic divergences among individuals belonging to one species/between species belonging to one genus of the five orders, Blattaria, Coleoptera, Hymenoptera, Lepidoptera and Diptera, were 0.59%/13.18%, 0.84%/20.10%, 0.02%/22.61%, 0.24%/3.48% and 0.17%/15.90%, respectively. In conclusion, we established the first DNA barcode dataset and confirmed its efficiency for identifying food‐associated insect pests in Korea.
The integration of climate change, spatial dynamics, and habitat fragmentation: A conceptual overview
Authors: HOLYOAK Marcel , HEATH Sacha K. 
Published: October 2015

AbstractA growing number of studies have looked at how climate change alters the effects of habitat fragmentation and degradation on both single and multiple species; some raise concern that biodiversity loss and its effects will be exacerbated. The published literature on spatial dynamics (such as dispersal and metapopulation dynamics), habitat fragmentation and climate change requires synthesis and a conceptual framework to simplify thinking. We propose a framework that integrates how climate change affects spatial population dynamics and the effects of habitat fragmentation in terms of: (i) habitat quality, quantity and distribution; (ii) habitat connectivity; and (iii) the dynamics of habitat itself. We use the framework to categorize existing autecological studies and investigate how each is affected by anthropogenic climate change. It is clear that a changing climate produces changes in the geographic distribution of climatic conditions, and the amount and quality of habitat. The most thorough published studies show how such changes impact metapopulation persistence, source–sink dynamics, changes in species' geographic range and community composition. Climate‐related changes in movement behavior and quantity, quality and distribution of habitat have also produced empirical changes in habitat connectivity for some species. An underexplored area is how habitat dynamics that are driven by climatic processes will affect species that live in dynamic habitats. We end our discussion by suggesting ways to improve current attempts to integrate climate change, spatial population dynamics and habitat fragmentation effects, and suggest distinct areas of study that might provide opportunities for more fully integrative work