bluuebunny/crossref_metadata_2025_split huggingface dataset:
Canadian Pain Society and Canadian Rheumatology Association Recommendations for Rational Care of Persons with Fibromyalgia. A Summary Report
Authors: Fitzcharles Mary-Ann , Ste-Marie Peter A. , Goldenberg Don L. , Pereira John X. , Abbey Susan , Choinière Manon , Ko Gordon , Moulin Dwight E. , Panopalis Pantelis , Proulx Johanne , Shir Yoram 
Published: July 2013

Objective.To summarize the development of evidence-based guidelines for the clinical care of persons with fibromyalgia (FM), taking into account advances in understanding of the pathogenesis of FM, new diagnostic criteria, and new treatment options.Methods.Recommendations for diagnosis, treatment, and patient followup were drafted according to the classification system of the Oxford Centre for Evidence-Based Medicine, and following review were endorsed by the Canadian Rheumatology Association and the Canadian Pain Society.Results.FM is a polysymptomatic syndrome presenting a spectrum of severity, with a pivotal symptom of body pain. FM is a positive clinical diagnosis, not a diagnosis of exclusion, and not requiring specialist confirmation. There are no confirmatory laboratory tests, although some investigation may be indicated to exclude other conditions. Ideal care is in the primary care setting, incorporating nonpharmacologic and pharmacologic strategies in a multimodal approach with active patient participation. The treatment objective should be reduction of symptoms, but also improved function using a patient-tailored treatment approach that is symptom-based. Self-management strategies combining good lifestyle habits and fostering a strong locus of control are imperative. Medications afford only modest relief, with doses often lower than suggested, and drug combinations used according to clinical judgment. There is a need for continued reassessment of the risk-benefit ratio for any drug treatment. Outcome should be aimed toward functioning within a normal life pattern and any culture of disablement should be discouraged.Conclusion.These guidelines should provide the health community with reassurance for the global care of patients with FM with the aim of improving patient outcome by reducing symptoms and maintaining function.
Magnetic Resonance Imaging Compared to Conventional Radiographs for Detection of Chronic Structural Changes in Sacroiliac Joints in Axial Spondyloarthritis
Authors: Poddubnyy Denis , Gaydukova Inna , Hermann Kay-Geert , Song In-Ho , Haibel Hildrun , Braun Jürgen , Sieper Joachim 
Published: July 2013

Objective.We investigated the performance of magnetic resonance imaging (MRI) compared to conventional radiographs for detection of chronic structural changes in the sacroiliac joints (SIJ) in patients with axial spondyloarthritis (SpA).Methods.We included 112 patients with definite axial SpA (68 with ankylosing spondylitis and 44 with nonradiographic axial SpA), for whom radiographs and MRI scans of the SIJ performed at the same time were available. Radiographs and MRI of the SIJ were scored for subchondral sclerosis (score 0–2), erosions (score 0–3), and joint space changes (score 0–5) in each SIJ. Readers provided an overall impression of the extent of damage according to the scoring system of the modified New York criteria.Results.In total, 224 SIJ from 112 patients were available for analysis. There was rather low agreement between MRI and radiographs concerning definite erosions of SIJ (κ = 0.11), moderate agreement for definite subchondral sclerosis (κ = 0.46) and definite joint space abnormalities (κ = 0.41), and almost perfect agreement for joint ankylosis (κ = 0.85). MRI demonstrated a good overall performance in detection of definite “chronic” sacroiliitis, with a sensitivity of 84% and a specificity of 61%. For sacroiliitis fulfilling the modified New York criteria, MRI had a sensitivity of 81% and a specificity of 64% using radiographs as the reference method.Conclusion.MRI demonstrated good overall performance for detection of chronic structural changes in the SIJ as compared to radiographs.
Les plis du capitalisme cognitif
Authors: Auray Nicolas 
Published: July 2013

On s’intéresse à un roman, Théorie de l’information d’Aurélien Bellanger (Gallimard, 2012), qui est, de l’invention du Minitel à l’empire des fournisseurs d’accès, une fresque de la rupture industrielle induite par la révolution numérique. Mise en réseaux, passion hédoniste de l’activité libre, créativité diffuse, individualisme non possessif : il y est raconté, entre sociologie et fiction, l’émergence du capitalisme cognitif et l’irrésistible ascension d’un de ses entrepreneurs emblématiques. La tolérance au désordre et la terreur que cela engendre en font un roman d’horreur du capitalisme cognitif, un récit de l’oscillation tragique entre perte en monde et affrontement au chaos.
Émotions privées, émotions publiques
Authors: Paperman Patricia 
Published: July 2013

L’article examine le privilège accordé par les principales analyses sociologiques des émotions aux émotions et sentiments « collectifs », ou rattachables à des règles sociales de cadrage ou d’interprétation des situations. Il soutient que la pertinence sociologique des émotions réside aussi dans l’identification et la compréhension de ces émotions et sentiments dits « particuliers », « individuels », « personnels », « privés », en décalage avec « la situation ». Les travaux sur les émotions issus de perspectives féministes reconsidèrent ces qualifications – « particulières », « personnelles » – comme un produit de relations sociales, i.e. de domination. Une analyse des émotions, à partir d’une position subordonnée ou dominée, emprunte d’autres chemins dégageant une dimension politique des émotions. Une vision restrictive de la moralité et une vision extensive et conformiste du social font obstacle à un compte rendu sociologiquement acceptable de la moralité des émotions.
Unilateral Rainbow Glare After Uncomplicated Femto-LASIK Using the FS-200 Femtosecond Laser
Authors: Gatinel Damien , Saad Alain , Guilbert Emmanuel , Rouger Hélène 
Published: July 2013

PURPOSE:
To report a case of rainbow glare following femtosecond laser-assisted LASIK (femto-LASIK) with the Wavelight FS-200 femtosecond laser (Alcon Laboratories, Inc., Fort Worth, TX).

METHODS:
A patient was treated bilaterally for myopia with femto-LASIK using the FS-200 femtosecond laser. Postoperatively, he complained of rainbow glare in his right eye.

RESULTS:
Three months postoperatively, the induced grating pattern (hyperreflective spot-like zones corresponding to the surgeon-programmed spot and line separation distance of the FS-200 femtosecond laser) was demonstrated with confocal microscopy at the level of the flap interface in the right eye.

CONCLUSIONS:
This is the first report of rainbow glare following femto-LASIK with the FS-200 femtosecond laser documented with in vivo confocal microscopy.

[
J Refract Surg.
2013;29(7):498–501.]
ICL Versus Veriflex Phakic IOL for Treatment of Moderately High Myopia: Randomized Paired-Eye Comparison
Authors: Awadein Ahmed , Habib Ahmed E. 
Published: July 2013

PURPOSE:
To compare the objective and subjective outcome of implantable collamer lenses (ICLs; Staar Surgical, Monrovia, CA) versus Veriflex lenses (AMO, Santa Ana, CA) for the correction of moderately high myopia.

METHODS:
A prospective randomized comparative eye study was performed on 24 patients with bilateral myopia that ranged from −6 to −14.5 diopters (D). One eye was implanted with an ICL and the other eye was implanted with a Veriflex phakic intraocular lens (PIOL). Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), higher-order aberrations (HOAs), contrast sensitivity, patient satisfaction, central endothelial cell count, and PIOL centration were determined 6 months after surgery

RESULTS:

The logMAR UDVA and CDVA improved significantly in both groups (
P
< .001). There was no statistically significant difference in postoperative logMAR UDVA (
P
= .41) or logMAR CDVA (
P
= .36) between the two groups. Postoperative deviation from target refraction was −0.06 ± 0.41 D in the ICL group and −0.07 ± 0.49 D in the Veriflex group (
P
= .15). The difference in both induced and absolute postoperative HOAs between groups was not statistically significant. The area under the log contrast sensitivity function increased significantly in both groups postoperatively. The difference in patient satisfaction between both PIOLs was not statistically significant. A higher but statistically insignificant central endothelial cell count loss occurred in the Veriflex group (
P
= .11).

CONCLUSION:
Both ICL and Veriflex PIOLs have equally satisfactory objective and subjective visual outcomes after surgery.

[
J Refract Surg.
2013;29(7):445–452.]
Astigmatism Correction With Toric IOL: Analysis of Visual Performance, Position, and Wavefront Error
Authors: Toto Lisa , Vecchiarino Luca , D’Ugo Erminia , Cardone Daniela , Mastropasqua Alessandra , Mastropasqua Rodolfo , Di Nicola Marta 
Published: July 2013

PURPOSE:
To evaluate astigmatism correction, visual performance, intraocular lens (IOL) position, and wavefront error after implantation of toric IOLs in patients with cataract.

METHODS:
This prospective study comprised 30 eyes of 30 patients with cataract who were candidates for phacoemulsification and implantation of the AcrySof toric IOL (Alcon Laboratories, Inc., Fort Worth, TX). Mean preoperative corneal keratometric and subjective refractive cylinder were 2.10 ± 0.47 and 2.17 ± 0.41 diopters (D), respectively.

RESULTS:

The refractive cylinder decreased significantly from 2.17 ± 0.41 to 0.73 ± 0.45 D (
P
= .001) at 180 days postoperatively. The difference between preoperative corneal astigmatism and postoperative refractive astigmatism was statistically significant (
P
< .05). At 180 days postoperatively, the uncorrected distance visual acuity was 0.20 logMAR (Snellen 20/32) in 100% of patients and 0.0 logMAR (Snellen 20/20) in 64% of patients. The root mean square of internal coma and trefoil aberrations showed a trend toward reduction; internal spherical aberration significantly decreased, whereas corneal trefoil aberration significantly increased (
P
< .05). A low amount of IOL decentration and tilt were detected at 30 and 180 days postoperatively, respectively.

CONCLUSIONS:
Toric IOL implantation is an effective procedure for correction of preexisting corneal astigmatism, improving visual performance, and inducing a low amount of higher-order aberrations. Moreover, the toric IOLs is well positioned early after surgery and stable over time.

[
J Refract Surg.
2013;29(7):476–483.]
Comparison of IOL Power Calculation Methods and Intraoperative Wavefront Aberrometer in Eyes After Refractive Surgery
Authors: Canto Ana Paula , Chhadva Priyanka , Cabot Florence , Galor Anat , Yoo Sonia H. , Vaddavalli Pravin K. , Culbertson William W. 
Published: July 2013

PURPOSE:
To compare preoperative methods for calculating intraocular lens (IOL) power versus the intraoperative wavefront aberrometer in eyes with a history of refractive surgery.

METHODS:
A retrospective study of 46 eyes (33 patients) with previous refractive surgery that underwent subsequent cataract surgery was conducted. Suggested IOL power predicted by ORange intraoperative wavefront aberrometer (WaveTec Vision Systems, Inc., Aliso Viejo, CA) was compared to power predicted by the (1) SRK-T formula using keratometry and axial length measurements from the IOLMaster (Carl Zeiss Meditec, Dublin, CA), (2) average central keratometry (Avg K) from corneal topography, and (3) average IOL power predicted by the American Society of Cataract and Refractive Surgery (ASCRS) web site. No historical information was used for the calculations. IOL power required for emmetropia was back-calculated using manifest refraction and implanted IOL power after cataract surgery.

RESULTS:
Mean age was 60 ± 7.9 years. Fifteen percent had a history of myopic photorefractive keratectomy (n = 7), 57% myopic LASIK (n = 26), 13% hyperopic LASIK (n = 6), and 22% radial keratectomy (RK) (n = 10). In 37% of cases, ORange predicted IOL power to within ±0.50 diopters (D) of emmetropia, compared to 30% for IOLMaster keratometry, 26% for Avg K, and 17% for ASCRS web site. In eyes after myopic treatment, ORange, IOLMaster, Avg K, and ASCRS web site predicted within ±0.50 D of emmetropia in 39%, 27%, 24%, and 18%, respectively, and within ±1.0 D in 60%, 39%, 39%, and 51%, respectively. In eyes after RK, ORange, Avg K, and ASCRS web site predicted to within ±0.50 D of emmetropia in 14% and the IOLMaster in 43% cases.

CONCLUSIONS:
Although the ORange most often predicted to within ±0.5 D of emmetropia, no method was able to achieve this accuracy more than 50% of the time. Predictions for eyes after RK were worse than for other types of refractive procedures.

[
J Refract Surg.
2013;29(7):484–489.]
Effect of Hydration State and Storage Media on Corneal Biomechanical Response From In Vitro Inflation Tests
Authors: Kling Sabine , Marcos Susana 
Published: July 2013

PURPOSE:
To evaluate corneal deformation with varying intraocular pressure and the dependency of the biomechanical response on the corneal hydration state, modulated by the storage solutions or postmortem period.

METHODS:
Thirty fresh enucleated porcine eyes were used for in vitro whole eye globe inflation experiments. The eyes were separated into five groups and treated with different solutions: 20% dextran, 8% dextran, 0.125% riboflavin–20% dextran, Optisol-GS (Bausch & Lomb, Rochester, NY), and one control group of virgin (untreated) eyes. Intraocular pressure was increased (from 15 to 55 mm Hg) and decreased (to 15 mm Hg) in 5-mm Hg steps and Scheimpflug images were taken at each step. Measurements were repeated after 24 hours. Thickness and curvature changes were analyzed as a function of intraocular pressure.

RESULTS:

Corneal deformation differed across conditions and hydration states. Dehydration by any dextran solution increased the hysteresis after the inflation/deflation cycle (14.29 vs 22.07 to 41.75
μ
m), whereas overnight hydration did not lead to a significant difference. Compared to control corneas, corneas treated with Optisol-GS showed the most similar behavior. Corneas treated with 0.125% riboflavin–20% dextran deformed most (Δthickness
max
= 38.27
μ
m), indicating a softening of the corneal tissue compared to control corneas (23.18
μ
m) and corneas treated with 8% dextran (21.01
μ
m) and 20% dextran (29.07
μ
m). Dextran instillation decreased corneal thickness on average to 56.5% at 0 hours and 72.7% at 24 hours.

CONCLUSIONS:
Corneal hydration and tissue preservation changed corneal biomechanics, in particular its relaxation over a period of 24 hours.

[
J Refract Surg.
2013;29(7):490–497.]
Rotationally Asymmetric Multifocal IOL Implantation in Acquired Nystagmus With Spectacle and Contact Lens Intolerance
Authors: Amigó Alfredo , Bonaque Sergio 
Published: July 2013

PURPOSE:
To describe a case of refractive lens exchange with multifocal intraocular lens implantation in a 52-year-old woman with emmetropic presbyopia who had near glasses and contact lens intolerance after acquired nystagmus.

METHODS:
Preoperative corrected distance visual acuity was 20/25 in the right eye, 20/20 in the left eye, and 20/20 binocularly. Corrected near visual acuity was 20/30 in the right eye and 20/20 in the left eye, reaching 20/20 binocularly but showing unsatisfactory binocular vision with asthenopia and intolerance to prolonged reading. The surgical plan entailed bilateral implantation of multifocal intraocular lens.

RESULTS:
Three months postoperatively, uncorrected distance visual acuity was 20/20 in the right eye and 20/20 in the left eye, reaching 20/20 binocularly. Monocular and binocular uncorrected near visual acuity of 20/20 was achieved without symptoms of asthenopia in prolonged reading. There were no changes in nystagmus characteristics after surgery.

CONCLUSIONS:
Multifocal intraocular lens implantation to manage a case of clinically significant acquired nystagmus may be a safe alternative, especially if others options have failed.

[
J Refract Surg.
2013;29(7):506–508.]
Censoring of Self-Reactive B Cells by Follicular Dendritic Cell–Displayed Self-Antigen
Authors: Yau Irene W. , Cato Matthew H. , Jellusova Julia , Hurtado de Mendoza Tatiana , Brink Robert , Rickert Robert C. 
Published: July 2013

AbstractIn the secondary lymphoid organs, intimate contact with follicular dendritic cells (FDCs) is required for B cell retention and Ag-driven selection during the germinal center response. However, selection of self-reactive B cells by Ag on FDCs has not been addressed. To this end, we generated a mouse model to conditionally express a membrane-bound self-antigen on FDCs and to monitor the fate of developing self-reactive B cells. In this article, we show that self-antigen displayed on FDCs mediates effective elimination of self-reactive B cells at the transitional stage. Notwithstanding, some self-reactive B cells persist beyond this checkpoint, showing evidence of Ag experience and intact proximal BCR signaling, but they are short-lived and unable to elicit T cell help. These results implicate FDCs as an important component of peripheral B cell tolerance that prevents the emergence of naive B cells capable of responding to sequestered self-antigens.
Histamine H2 Receptor Signaling in the Pathogenesis of Sepsis: Studies in a Murine Diabetes Model
Authors: Carlos Daniela , Spiller Fernando , Souto Fabrício O. , Trevelin Silvia C. , Borges Vanessa F. , de Freitas Andressa , Alves-Filho José C. , Silva João S. , Ryffel Bernhard , Cunha Fernando Q. 
Published: July 2013

AbstractType 1 diabetes enhances susceptibility to infection and favors the sepsis development. In addition, diabetic mice produced higher levels of histamine in several tissues and in the blood after LPS stimulation than nondiabetic mice. In this study, we aimed to explore the role of mast cells (MCs) and histamine in neutrophil migration and, consequently, infection control in diabetic mice with mild sepsis (MS) induced by cecum ligation and puncture. We used female BALB/c, MC-sufficient (WB/B6), MC-deficient (W/Wv), and NOD mice. Diabetic mice given MS displayed 100% mortality within 24 h, whereas all nondiabetic mice survived for at least 5 d. The mortality rate of diabetic mice was reduced to 57% after the depletion of MC granules with compound 48/80. Moreover, this pretreatment increased neutrophil migration to the focus of infection, which reduced systemic inflammatory response and bacteremia. The downregulation of CXCR2 and upregulation of G protein–coupled receptor kinase 2 in neutrophils was prevented by pretreatment of diabetic mice given MS with compound 48/80. In addition, blocking the histamine H2 receptor restored neutrophil migration, enhanced CXCR2 expression, decreased bacteremia, and improved sepsis survival in alloxan-induced diabetic and spontaneous NOD mice. Finally, diabetic W/Wv mice had neutrophil migration to the peritoneal cavity, increased CXCR2 expression, and reduced bacteremia compared with diabetic WB/B6 mice. These results demonstrate that histamine released by MCs reduces diabetic host resistance to septic peritonitis in mice.
The Archaic Roles of the Amphioxus NF-κB/IκB Complex in Innate Immune Responses
Authors: Yuan Shaochun , Zhang Jie , Zhang Lingling , Huang Ling , Peng Jian , Huang Shengfeng , Chen Shangwu , Xu Anlong 
Published: July 2013

Abstract
NF-κB transcription factors play important roles in immune responses and the development of the immune system. Many aspects of NF-κB signaling differ significantly among distinct species, although many similarities in signaling exist in flies and humans. Thus, to understand the functional refinement of the NF-κB cascade from invertebrates to vertebrates, the Rel and NF-κB proteins, identified as bbtRel and bbtp105, were characterized in a basal chordate amphioxus. Consistent with the sequence similarities, bbtRel was found to interact with a mammalian κB response element, to move into the nucleus when activated, and to be inhibited by the NF-κB–specific inhibitor helenalin. Similar to the other class I members, bbtp105 could be cleaved into the mature form p58. Such endoproteolysis depends on the GRR sequence and requires both protease degradation and caspase 8 cleavage. Furthermore, we found that bbtIκB and the unprocessed bbtp105 can inhibit the transcriptional activity of bbtRel, whereas bbtp58 forms homodimers or heterodimers with bbtRel to create a mature NF-κB complex. Finally, we found that the survival rate and the expression of bbtIκB and TNF-α–like genes were decreased when adult amphioxus were treated with helanalin before immune challenge, suggesting the archaic roles for NF-κB signaling in innate immune responses in a basal chordate. The presence of the NF-κB–IκB cascade in amphioxus indicates that it is a significant feature linking invertebrates to vertebrates and is refined in vertebrates through the expansion and divergence of genes involved in the cascade.
Regulation of Adaptive Immunity by the Fractalkine Receptor during Autoimmune Inflammation
Authors: Garcia Jenny A. , Pino Paula A. , Mizutani Makiko , Cardona Sandra M. , Charo Israel F. , Ransohoff Richard M. , Forsthuber Thomas G. , Cardona Astrid E. 
Published: July 2013

Abstract
Fractalkine, a chemokine anchored to neurons or peripheral endothelial cells, serves as an adhesion molecule or as a soluble chemoattractant. Fractalkine binds CX3CR1 on microglia and circulating monocytes, dendritic cells, and NK cells. The aim of this study is to determine the role of CX3CR1 in the trafficking and function of myeloid cells to the CNS during experimental autoimmune encephalomyelitis (EAE). Our results show that, in models of active EAE, Cx3cr1−/− mice exhibited more severe neurologic deficiencies. Bone marrow chimeric mice confirmed that CX3CR1 deficiency in bone marrow enhanced EAE severity. Notably, CX3CR1 deficiency was associated with an increased accumulation of CD115+Ly6C−CD11c+ dendritic cells into EAE-affected brains that correlated with enhanced demyelination and neuronal damage. Furthermore, higher IFN-γ and IL-17 levels were detected in cerebellar and spinal cord tissues of CX3CR1-deficient mice. Analyses of peripheral responses during disease initiation revealed a higher frequency of IFN-γ– and IL-17–producing T cells in lymphoid tissues of CX3CR1-deficient as well as enhanced T cell proliferation induced by CX3CR1-deficient dendritic cells. In addition, adoptive transfer of myelin oligodendrocyte glycoprotein35–55-reactive wild-type T cells induced substantially more severe EAE in CX3CR1-deficient recipients when compared with wild-type recipients. Collectively, the data demonstrate that besides its role in chemoattraction, CX3CR1 is a key regulator of myeloid cell activation contributing to the establishment of adaptive immune responses.