bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticoagulation methods used and role of antithrombin III level monitoring in children on continuous renal replacement therapy: an observational cross-sectional study
Authors: Fadel Fatina Ibrahim , Bazaraa Hafez Mahmoud , Anis Shahira Kamal , Mohamed Noha Mahmoud , Fahmy Yosra Aboelnaga 
Published: August 2024

Abstract
Background
In critically ill cases, CRRT is a renal replacement intervention. The most common reason why CRRT terminates prematurely (non-electively) is clotting in the extracorporeal circuit, more especially in the filter.

Aim of work
To determine the frequency of thrombotic and hemorrhage complications throughout CRRT, the role of antithrombin III level monitoring, the type of anticoagulation, and the dose and laboratory tests utilized to monitor it.

Method
The study was carried out on 58 children who were undergoing CRRT. The children underwent a comprehensive history-taking, assessment, CRRT prescription parameters and alterations, vascular access data, anticoagulation type, dose, and adjustment, as well as monitoring of antithrombin III levels. Furthermore, any extracorporeal circuit clotting or bleeding was documented.

Results
Of the 58 sessions that were examined, 25 (43.1%) resulted in filter clotting. The indication was cured in 16 cases (27.6%), 8 cases (13.8%) resulted in the patient’s mortality, and 9 cases (15.5%) had life-threatening bleeding. The remaining 33 cases (56.9%) were not terminated with filter clotting. Forty-one (70.7%) of studied sessions used unfractionated heparin as anticoagulation, 22.4% used heparin-protamine, 5.2% was not anticoagulated, and one circuit (1.7%) was anticoagulated using regional citrate.
Filter clotting incidence was significantly related to activated partial thromboplastin time (a PTT) value at the end of sessions (P value = 0.000), and platelets count after 4 h of session initiation (P value = 0.048). Antithrombin III levels pre-heparin infusion less than 80 were found in patients who received higher doses of a heparin bolus dose, median dose 35 (IQR 20–35), this relation is statistically significant (P value = 0.042).

Conclusion
In the 58 cases that were examined, the incidence of bleeding was 32.8%; however, 19% of the cases were not severe. The incidence of filter clotting was 43.1% in the study group. a PTT value at the end of sessions, and platelets count after 4 h could be predictors of thrombotic complications during CRRT, antithrombin III deficiency before sessions is a predictor of filter clotting.
Mechanical properties of a novel friction dampers incorporated with buckling restrained shape memory alloy bars
Authors: Yang Weifeng , Cao Sasa , Liu Wenxian , Dang Xinzhi 
Published: August 2024

AbstractTo improve the energy dissipation and self-resetting ability of bridge structures under strong earthquakes, a new buckling-restrained SMA bar-based friction damper (SFD) is proposed. The damper is composed of buckling-restrained super-elastic SMA bars, friction pads, and a steel frame. The buckling-restrained SMA bars provide self-reset capability, while the friction pads provide additional energy dissipation capacity. Firstly, the configuration, working mechanism, and restoring force model of the SMA bar-based friction damper are introduced. Secondly, a specimen of the damper is made, and the pseudo-static test is carried out. Finally, the experimental results are analyzed based on the Abaqus finite element model. The results indicate that the damper has better self-resetting ability and energy dissipation capacity.
Virtual reality assessment of reaching accuracy in patients with recent cerebellar stroke
Authors: Du Khai , Benavides Leonardo R. , Isenstein Emily L. , Tadin Duje , Busza Ania C. 
Published: August 2024

Abstract
Background
Dysmetria, the inability to accurately estimate distance in motor tasks, is a characteristic clinical feature of cerebellar injury. Even though subjective dysmetria can be quickly detected during the neurological examination with the finger-to-nose test, objective quantification of reaching accuracy for clinical assessment is still lacking. Emerging VR technology allows for the delivery of rich multisensory environmental stimuli with a high degree of control. Furthermore, recent improvements in the hand-tracking feature offer an opportunity to closely examine the speed, accuracy, and consistency of fine hand movements and proprioceptive function. This study aims to investigate the application of virtual reality (VR) with hand tracking in the rapid quantification of reaching accuracy at the bedside for patients with cerebellar stroke (CS).

Methods and results
Thirty individuals (10 CS patients and 20 age-matched neurologically healthy controls) performed a simple task that allowed us to measure reaching accuracy using a VR headset (Oculus Quest 2). During this task, the participant was asked to reach for a target placed along a horizontal sixty-degree arc. Once the fingertip passed through the arc, the target immediately extinguished. 50% of the trials displayed a visible, real-time rendering of the hand as the participant reached for the target (visible hand condition), while the remaining 50% only showed the target being extinguished (invisible hand condition). The invisible hand condition isolates proprioception-guided movements by removing the visibility of the participant’s hand. Reaching error was calculated as the difference in degrees between the location of the target, and where the fingertip contacted the arc. Both CS patients and age-matched controls displayed higher average reaching error and took longer to perform a reaching motion in the invisible hand condition than in the visible hand condition. Reaching error was higher in CS than in controls in the invisible hand condition but not in the visible hand condition. Average time taken to perform each trial was higher in CS than in controls in the invisible hand conditions but not in the visible hand condition.

Conclusions
Reaching accuracy assessed by VR offers a non-invasive and rapid approach to quantifying fine motor functions in clinical settings. Furthermore, this technology enhances our understanding of proprioceptive function in patients with visuomotor disabilities by allowing the isolation of proprioception from vision. Future studies with larger cohorts and longitudinal designs will examine the quantitative changes in reaching accuracy after stroke and explore the long-term benefits of VR in functional recovery.
Cyanobacteria and their metabolites - can they be helpful in the fight against pathogenic microbes?
Authors: Grabowski Łukasz , Wiśniewska Karolina , Żabińska Magdalena , Konarzewska Maria , Zielenkiewicz Monika , Rintz Estera , Cyske Zuzanna , Gaffke Lidia , Pierzynowska Karolina , Mazur-Marzec Hanna , Węgrzyn Grzegorz 
Published: August 2024

AbstractNatural ecosystems are a rich source of compounds that can be considered as drugs to combat viral and bacterial infections. Cyanobacteria play a key role in the search for these compounds. These microorganisms, besides their well-known cytotoxicity to humans, are also a rich reservoir of metabolites with antiviral and antibacterial activities. These compounds are extremely diverse in their chemical structures. Moreover, recent reports have shown that Cyanobacteria can be used as platforms for the synthesis of antibacterial molecules such as gold and silver nanoparticles. In this review, we summarize and discuss recent reports on antiviral significance of these metabolites against the most relevant viruses, such as Human Immunodeficiency Virus (HIV), Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), Herpes Simplex Virus (HSV), and Influenza Virus. We also focus on the effects of cyanobacterial metabolites against Gram-positive bacteria, including Staphylococcus aureus, as well as Gram-negative bacteria, including those from the ESKAPE group of pathogens. It is outlined what future research on the isolation of cyanobacterial metabolites should focus on to improve the effectiveness of this process and lead to the commercialization of widely available drugs for the pharmaceutical market.
Biosynthesis of polyhydroxyalkanoate copolymers consisting of α-methylated monomer units from glucose and propionate: thermal properties and chiral configuration
Authors: Miyahara Yuki , Ishino Marii , Nomura Christopher T. , Taguchi Seiichi , Abe Hideki , Tsuge Takeharu 
Published: August 2024

Abstract
Background
Expression of the Ascaris suum ketothiolase (Acat3) in recombinant Escherichia coli enables the production of α-methylated monomers such as 3-hydroxy-2-methylvalerate (3H2MV) and 3-hydroxy-2-methylbutyrate (3H2MB) for polyhydroxyalkanoate (PHA) biosynthesis from glucose and propionate as carbon sources. However, the chiral configurations and thermal properties of biosynthesized PHAs remain poorly understood.

Results
In this study, 3-hydroxybutyrate (3HB)-based PHA copolymers containing 3H2MV and 3H2MB units were synthesized from glucose and propionate using Acat3-expressing Escherichia coli LSBJ. The 3H2MV fraction of the synthesized PHA reached 15.7 mol%, while the 3H2MB fraction remained at approximately 0.2 mol%. Chirality analysis revealed that (2S,3R)- and (2R,3R)-3H2MV units were both detected; however, (2R,3R)-3H2MV units were dominant in the PHA copolymer produced by the strain expressing the (R)-specific enoyl-CoA hydratase (PhaJAc). To evaluate the effect of α-methylated monomers on the crystallization behavior of PHA copolymers, cold crystallization was compared for PHA polymers with different mol% 3-hydroxyvalerate (3HV) monomer units. The cold crystallization of the copolymer containing 11 mol% 3H2MV and 30 mol% 3HV was detected at 68 °C, while the non-α-methylated copolymer containing 24 mol% 3HV did not exhibit cold crystallization, indicating that α-methylated PHA had a greater tendency to crystallize.

Conclusions
This study conclusively demonstrated that (2S,3R)- and (2R,3R)-3H2MV units were both incorporated into PHA by expressing Acat3; however, the (2R,3R)-isomer became the dominant 3H2MV unit in the PHA copolymers by additionally expressing PhaJAc. The 3H2MV repeating unit facilitated the crystallization of PHA copolymers despite the high fraction of the 3HV unit.

Graphical Abstract
Structure and formation of mud volcanoes in the South Caspian Basin according to seismic data
Authors: Yusubov Namaz P. , Guliyev Ibragim S. , Soto Juan I. 
Published: August 2024

The South Caspian Basin (SCB) constitutes a classic province to study mud volcanoes and their associated processes. Approximately 280 active mud volcanoes have been documented in the offshore and the onshore areas of Azerbaijan, emitting water, hydrocarbons (oil and mainly methane), and fluidized muds that transport solid fragments from deep sedimentary sequences. Seismic characteristics of mud volcano systems in the Azerbaijan area of the SCB are used to address (1) the nature of the mud volcano source layer; (2) the internal geometry of the feeder systems; and (3) the processes associated with shale mobilization and extrusion. We confirm that the source layer is mainly the Maykop Suite (Oligocene-Lower Miocene), which is a thick (≤3 km) and deep (>10 km) clayey sequence rich in organic matter. This layer was quickly buried due to basin subsidence and the rapid deposition (since the Middle Miocene) of thick fluvio-lacustrine sediments of the Productive Series (PS) (Upper Miocene-Upper Pliocene), which contributed to the creation of high pore pressures and the transformation of organic matter into methane (through thermal cracking). Since the Middle Miocene and more important, during the Upper Pliocene, the Maykop shales mobilized due to an increase in shear stresses and pore pressures, which promoted a decrease in effective stresses and, as a consequence, facilitated the achievement of critical state conditions in the shales that began to flow. This process, repeated over time, allowed multiple pulses of shale mobilization to originate (as in a loading piston system). Shale piercing transporting deep-sourced fluids (and hydrocarbons) was carried out through fractures in the outer arc of anticlines, forming subvertical feeder systems. The mobilized hydrocarbons and fluids also recharged some of the younger and more permeable layers of the PS, creating shallower reservoirs in the vicinities of the mud volcano structures.
Sebaran Jenis Lamun di Perairan Pulau Panjang, Jepara
Authors: Nor Muhammad Muallifin , Suryono Chrisna Adhi , Endrawati Hadi 
Published: August 2024

Lamun adalah tumbuhan berbunga yang hidup di perairan dangkal dengan pengaruh sinar matahari. Lamun memiliki ciri morfologi yaitu daun, batang dan akar. Lamun dapat tumbuh dengan membentuk padang lamun yang terdiri dari satu atau lebih jenis lamun. Lamun tumbuh di perairan dengan substrat pasir dan berlumpur. Lamun memiliki fungsi ekologi yang banyak diantaranya adalah sebagai produktivitas primer, sumber makanan, menstabilkan sedimen, tempat asuhan dan habitat biota – biota laut. Ekosistem lamun menjadi ekosistem penting sehinga sebarannya di perairan perlu untuk dikaji. Penelitian ini dilakukan untuk mengetahui kerapatan lamun di Pulau Panjang, menggunakan metode line transek sehingga dapat diketahui komposisi lamun, dan kerapatan lamun. Berdasarkan penelitian diketahui bahwa di Pulau Panjang telah ditemukan empat jenis lamun dengan komposisi lamun yang paling banyak dijumpai adalah Thalassia hemprichii dan paling jarang dijumpai adalah Enhallus acoroides. Kerapatan jenis lamun tertinggi berada di stasiun 2 yaitu 283 tegakan/m2. Seagrass is a flowering plant that lives in shallow waters under the influence of sunlight. Seagrass has morphological characteristics, namely leaves, stems and roots,.Seagrass can grow by forming seagrass beds consisting of one or more types of seagrass. Seagrass grows in waters with sandy and muddy substrates. Seagrasses have many ecological functions, including primary productivity, food sources, stabilizing waters, nursery and habitat for marine biota. Seagrass ecosystems are important ecosystems so that their distribution in waters needs to be studied. This study was conducted to determine the density of seagrass in the Panjang Island, using the line transect method so that the composition, and density seagrass can be known. Based on the research, it is known that in Panjang Island, there were 4 species of seagrass have been found with the composition of the most common seagrass being Thalassia hemprichii and the least common being Enhallus acoroides. The highest density of seagrass species is at station 2, which is 283 ind/m2.
Korelasi Keanekaragaman Plankton Dengan Parameter Fisika-Kimia Perairan di Estuari Sungai Selan Kabupaten Bangka Tengah
Authors: Nazar Ahlun , Utami Eva , Umroh Umroh 
Published: August 2024

Plankton adalah organisme hidup kecil yang mengapung di kolom air dan merupakan komponen ekosistem perairan yang sangat penting. Penelitian ini bertujuan untuk mengetahui parameter fisika-kimia perairan, komposisi plankton dan korelasi antara keanekaragaman plankton dengan parameter fisika-kimia perairan dengan menggunakan analisis statistik. Penelitian ini dilakukan pada bulan Juni 2022 di estuari Sungai Selan, Kabupaten Bangka Tengah. Penelitian dilakukan pada pagi hari. Pengambilan data plankton dilakukan dengan metode tarikan vertikal menggunakan jaring plankton. Sampel plankton yang dihasilkan diidentifikasi di bawah mikroskop dengan tiga ulangan untuk setiap sampel di setiap titik pengamatan. Hasil penelitian menunjukkan bahwa terdapat 24 jenis plankton yang ditemukan di estuary Sungai Selan. Kelimpahan plankton tertinggi terdapat pada titik 4 dengan 701,38 ind/L dan terendah pada titik 1 dengan 197,91 ind/L. Indeks keanekaragaman plankton tertinggi pada titik 5 sebesar 2.202 dan terendah pada titik 3 sebesar 1.549. Indeks keseragaman tertinggi pada titik 5 sebesar 0,858 dan terendah pada titik 4 sebesar 0,687. Dominasi tertinggi pada poin 3 sebesar 0,269 dan terendah pada titik 5 sebesar 0,169. Hubungan antara parameter fisika-kimia dan keanekaragaman plankton menunjukkan bahwa kecepatan aliran arus berpengaruh paling signifikan terhadap keanekaragaman plankton di estuari Sungai Selan. Plankton are tiny living organisms that float in the water column and are an important component of aquatic ecosystems. This study aims to determine the physico-chemical parameters of the waters, plankton composition, and the correlation between the diversity of plankton and the physico-chemical parameters of the waters using statistical analysis. This research was conducted in June 2022 at the Selan River estuary in Central Bangka Regency. The research was conducted in the morning. Plankton data collection was carried out using the vertical pull method using a plankton net. The resulting plankton samples were identified under a microscope with three replicates for each sample at each observation point. The results showed that 24 types of plankton were found in the Selan River estuary. The highest plankton abundance was at point 4 with 701.38 ind/L, and the lowest was at point 1 with 197.91 ind/L. The highest plankton diversity index was at point 5 of 2,202, and the lowest was at point 3 of 1,549. The highest uniformity index is at point 5 of 0.858, and the lowest is at point 4 of 0.687. The highest dominance is at point 3 of 0.269, and the lowest is at point 5 of 0.169. The relationship between physico-chemical parameters and plankton diversity shows that current velocity significantly affects plankton diversity in the Selan River estuary.
Struktur Komunitas Makrozoobentos di Pantai Tanah Merah, Perairan IKN Baru, Kalimantan Timur
Authors: Suryana Irma , Ritonga Irwan Ramadhan , Paputungan Mohammad Sumiran , Agathajani Brigitha Anjeli , Elisar Elisar 
Published: August 2024

Makrozoobentos mampu hidup di sedimen lumpur, pasir, batu, kerikil maupun sampah organik di perairan laut, sungai, kolam ataupun danau. Ia merupakan organisme yang berperan dalam rantai makanan sebagai konsumen primer dan konsumen sekunder serta membantu terdistribusinya nutrien dan mineral di substrat perairan. Penelitian pendahuluan ini diharapkan dapat memberikan gambaran tentang struktur komunitas Makrozooobentos di pantai Tanah Merah Samboja, serta melihat jenis substrat sedimen dan kandungan nutriennya. Peletakkan kuadran plot berukuran 2 x 0,25 m2 pada luasan 2400 m2 yang terbagi menjadi 6 titik pengamatan pada zona subtidal memperoleh 182 individu Makrozooobentos yang teridentifikasi sebagai 19 spesies kelas Gastropoda, 15 spesies Bivalvia dan 1 spesies dari kelas Scapopoda. Kelimpahan total dikonfirmasi sebesar 228 ind/m2 dimana pola sebaran kelimpahan per titik linear dengan kandungan Nitrat, Ortofosfat, total Fosfat dan Karbon organik dalam sedimen. Indeks keanekaragaman, keseragaman dan dominansi secara berurutan terukur 3,085 (tinggi), 0,854 (tinggi) dan 0,064 (tidak ada jenis yang mendominasi). Adapun persentase fraksi pasir dalam kisaran 90-97% sebagai kategori tipe substrat. Macrozoobenthos lives on mud, sand, stone, gravel or organic waste in the ocean floor, river, pond or lake. It is an active organism in the food chain as a decomposer and contributes to spreading some nutrients and minerals on the sediment substrate. This first record research had been to describe the structure community of Macrozoobenthos at Tanah Merah’s beach in Samboja district, also analyzed the type of substrate and the composition of the nutrient. The laying plot in size 2 x 0,25 m2 on the area of 2400 m2, which divided into six substations was, found 182 individuals of Macrozoobenthos, which is confirmed as 19 species of Gastropods, 15 species of Bivalva and 1 species of Scaphopoda. The total abundance was 227,5 ind/m2, whereas each substation's distribution pattern had linearity with nitrate, orthophosphate, total phosphate, and C-organic contents in the sediment. The diversity, uniformity, and dominance index sequentially confirmed 3,085 (high), 0,854 (high), and 0,064 (low). Then, it was confirmed sand fraction in range 90-97% for the type of substrate.
Réflexions sur la situation de l’enseignement Récits d’enseignants et de futurs en-seignants / Reflexões sobre a situação de ensino: as falas de professores e futuros professores
Authors: De Fátima dos Santos Morais Jaqueline 
Published: August 2024

Ce texte cherche à réfléchir sur les différentes paroles produites par des étudiants et des étudiantes du cours des Lettres de la Faculté de Formation des Profes-seurs, une unité académique de l’UERJ située à São Gon-çalo, sur des thèmes se rapportant à l’identité enseignante et à la crise de l’enseignement. La recherche empirique a résulté dans la collecte de dialogues produits par ces su-jets, dont nombreux sont déjà enseignants, lors des classes de didactique dans les années 2000 et 2001. L’investigation nous montre que les difficultés qu’expérimentent les sujets, loin d’être individuelles, sont plutôt les difficultés d’une grande partie de l’enseignement et celles-ci ont besoin, en vue d’un possible dépassement, d’être examinées collectivement.

Este texto busca refletir sobre diferentes falas produzidas por alunos e alunas do curso de Letras da Faculdade de Formação de Professores, uma unidade acadêmica da UERJ localizada em São Gonçalo, sobre temas ligados a identidade docente e a crise do magistério. A pesquisa empírica resultou no recolhimento de diálogos produzidos por esses sujeitos, muitos deles já professores, durante as aulas de didática nos anos de 2000 e 2001. A investigação nos mostra que as dificuldades que vivem esses sujeitos, longe de serem individuais, são dificuldades de grande parte do magistério e precisam, para uma possível superação, serem refletidas coletivamente.
VARIASI DAN KELIMPAHAN PLANKTON DI PERAIRAN BRONDONG, KABUPATEN LAMONGAN
Authors: Handayani Muliawati , Nuzapril Mulkan 
Published: August 2024

Keberadaan plankton di suatu perairan digunakan sebagai indikator kuliatas air dan produktivitas primer perairan. Perairan Brondong dikenal sebagai salah satu penghasil ikan dari sektor perikanan tangkap di Pesisir Utara Jawa. Tujuan penelitian ini adalah untuk mengetahui variasi dan kelimpahan plankton serta kualitas air di Perairan Brondong, Lamongan. Sampling dilakukan pada 10 titik yang perairan sejajar dengan garis pantai menggunakan purposive sampling. Penelitian ini menggunakan metode deskriptif eksploratif untuk identifikasi plankton dan parameter fisika kimia perairan serta analisis PCA untuk mengetahui korelasi antar variabel. Ditemukan 32 genus jenis fitoplankton dan 11 genus zooplankton. Ceratium adalah genus yang paling banyak ditemukan pada komunitas fitoplankton. Kelimpahan Ceratium yang tinggi di suatu perairan mengindikasikan kuaitas air yang tercemar. Sedangkan genus zooplankton dengan kelimpahan tertinggi adalah Nauplius. Nauplius merupakan hewan kecil dari yang sedang mengalami perkembangan stadia, biasanya berasal dari golongan Copepoda. Indeks komunitas fitoplankton berada pada keanekaragaman yang sedang, sedangkan zooplankton tergolong keanekaragaman yang rendah. Indeks keseragaman keduanya tergolong kategori labil dan indeks dominasi tergolong rendah. Faktor utama yang memiliki korelasi erat dengan kelimpahan baik itu fitoplankton maupun zooplankton adalah parameter suhu, DO dan pH. Pemanfaatan pesisir dengan aktivitas yang beragam diduga berpengaruh terhadap kualitas air dan kelimpahan plankton.