bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential correlations of dentogenic factors to the development of clinically verified fungus balls: A retrospective computed tomography–based analysis
Authors: Tomazic Peter Valentin , Dostal Eva , Magyar Marton , Lang‐Loidolt Doris , Wolf Axel , Koele Wolfgang , Truschnegg Astrid , Stammberger Heinz , Payer Michael 
Published: July 2015

Objectives/HypothesisFungus balls are a common disease of the paranasal sinuses, usually involving the maxillary sinus. To clarify the pathology, we analyzed patients treated for maxillary sinus fungus balls to see whether the latter correlated with dentogenic factors.Study DesignRetrospective case analysis.MethodsCases of maxillary sinus fungus balls diagnosed between January 2000 and December 2013 were analyzed retrospectively. Patients' charts were reviewed for diagnosis, gender, and age. Paranasal sinus computed tomography (CT) scans were reviewed according to the side of the fungus ball, calcifications/opacifications, and dentogenic factors.ResultsIn 98/102 patients (96.1%), 157 dentogenic factors could be identified on the side affected by a fungus ball. On the contralateral healthy side, there were 125 dentogenic factors. In four (3.9%) of the patients, no dentogenic pathology was identified on the CT scan. The presence of dentogenic factors (regardless of number) was significantly associated with a fungus ball compared to the healthy side (P = .024, χ2 test, odds ratio: 2.72 [95% confidence interval: 1.02–7.23]).ConclusionsDentogenic factors regardless of type potentially correlate with the presence of maxillary sinus fungus ball. Unlike the overall presence of dentogenic factors, the particular dentogenic factors in an individual patient do not significantly influence the development of fungus balls. After diagnosis of dentogenic pathology in penetrated maxillary sinus floors, patients should be closely monitored and informed about their higher risk of developing a fungus ball.Level of Evidence4. Laryngoscope, 126:39–43, 2016
Pediatric facial fractures: Demographic determinants influencing clinical outcomes
Authors: Chan Kenny H. , Gao Dexiang , Bronsert Michael , Chevallier Keely M. , Perkins Jonathan N. 
Published: July 2015

Objectives/HypothesisThere is limited data linking demographic determinants to clinical outcomes in facial trauma, particularly when comparing regional to national datasets; these are the aims of the present study.Study DesignRetrospective chart review.MethodsA 10‐year, retrospective single‐institutional chart review was undertaken at Children's Hospital Colorado (CHC) to characterize a pediatric population with facial fractures. A comparative analysis between the CHC and National Trauma Data Bank (NTDB) datasets was also conducted.ResultsIn the CHC dataset, increased hospital stay was positively predicted by bilateral mandible fracture, skull, intracranial, spine, thoracic, abdominal, and limb injuries. Predictors of increased intensive‐care unit (ICU) stay included skull, spine, and limb injuries. The CHC cohort had younger subjects, more females, fewer African Americans, and more Hispanics than the NTDB dataset. They were more likely to be injured by nonviolent activities than by altercations. Divergent facial and associated injuries between the datasets were found. Multivariate models showed longer length of hospital stay for the CHC group (P = .0085), but the NTDB group had higher ICU admission (P = .04) and longer lengths of ICU stay (P = .007).ConclusionThe demographic disparities (age, ethnicity, mechanism of injury, and injury type) resulted in divergent injury patterns and likely influenced clinical outcomes.Level of Evidence4. Laryngoscope, 126:485–490, 2016
Role of saposin C and D in auditory and vestibular function
Authors: Lustig Lawrence R. , Alemi Sean , Sun Ying , Grabowski Gregory , Akil Omar 
Published: July 2015

Objectives/HypothesisSaposins are small proteins derived from a precursor protein, prosaposin. Each of the four saposins (A–D) is necessary for the activity of lysosomal glycosphingolipid hydrolases. Individual saposin mutations lead to lysosomal storage diseases, some of which are associated with hearing loss. Here we evaluate the effects of the loss of saposins C and D on auditory and vestibular function in transgenic mice.MethodsTransgenic mice with either loss of saposin C function or a combined loss of saposin C + D function were studied. Light microscopy and immunofluorescence were used to evaluate histologic and morphologic changes in the auditory and vestibular organs. Acoustic brainstem response thresholds and distortion product otoacoustic emissions were used to study the auditory phenotype.ResultsA null mutation of saposin C did not result in any identifiable histologic changes or loss of hearing through postnatal day 55. Combined losses of saposins C and D similarly did not result in any changes in organ of Corti histology or loss of hearing. However, inclusions within the vestibular end organs was noted, consistent with afferent and efferent neuronal sprouting, although to a much milder degree than seen in the previously studied prosaposin knockout mouse.ConclusionsLoss of saposin C and D function, although causing mild phenotypic changes in the vestibular end organs, otherwise results in minimal functional impairment and no changes in the auditory system. It is more likely that the auditory and vestibular effects of the loss of prosaposin are mediated through the actions of saposin A and/or B.Level of EvidenceNA. Laryngoscope, 126:452–459, 2016
Effects of different bronchoalveolar lavage methods on tracheobronchial foreign body patients
Authors: Luo Hua‐Nan , Ma Si‐Jing , Guo Hai‐Li , Wang Zheng‐Hui , Ren Xiao‐Yong 
Published: July 2015

Objectives/HypothesisTo compare the different effects of bronchoalveolar lavage (BAL) with diverse combinations of lidocaine, epinephrine, and dexamethasone on pediatric patients with an inhaled tracheobronchial foreign body (TFB).Study DesignRandomized controlled study.MethodsTwo hundred forty cases of pediatric patients with inhaled TFB were included in this study, and were randomly divided into four groups using three kinds of drugs for BAL, namely 0.9% saline (S) group, 2% lidocaine with diluted epinephrine (LE) group, 2% lidocaine with diluted epinephrine and 0.5% dexamethasone (LED), control group (C) without BAL. The incidences of intraoperative or postoperative complications and recovery periods were compared. Meanwhile, the concentrations of interleukin (IL)−1β, IL‐6, and tumor necrosis factor (TNF)‐α in BAL fluids and plasma were evaluated by enzyme‐linked immunosorbent assay.ResultsThe incidences of bronchospasm, hypoxemia, and postoperative fever were significantly lower in the LED group than other groups (P < .001). Fever after the TFB removal procedure appeared later in the LED group than the other groups. The improvement and healing periods in the LE and LED groups were significantly shorter than those in the C and S groups (P < .001). The concentrations of IL‐1β, IL‐6, and TNF‐α in BAL fluids were significantly higher in the LE and LED groups than those in the S group (P < .001), but those in the plasma of the C and S groups were lower compared with the LE and LED groups (P < .001).ConclusionsBAL with lidocaine, epinephrine, and dexamethasone could promote recovery for TFB patients and reduce incidences of complications, possibly by regulating release of proinflammatory cytokines.Level of Evidence1b. Laryngoscope, 126:1000–1005, 2016
Unplanned reoperations after microvascular free tissue transfer: An analysis of 2,244 patients using the american college of surgeons national surgical quality improvement program database
Authors: Kwok Alvin C. , Agarwal Jayant P. 
Published: July 2015

PurposeOur intent was to evaluate unplanned reoperations as a quality indicator for microvascular free tissue transfer (MFTT).MethodsThe National Surgical Quality Improvement Program database was used to identify MFTT cases from January 2012 to December 2013. Multivariate logistic regression models were used to determine risk factors for unplanned reoperations.ResultsWe identified 2,244 MFTT cases. There were 290 associated unplanned reoperations (12.92%). There was a threefold increase in the rate of complications when patients underwent reoperation (58.28% vs 18.12%, p < 0.0001). Head and neck reconstructions had the highest rate of reoperations (18.04%). Most reoperations were debridements (38.28%), followed by microvascular procedures (28.97%) and flap revisions (26.55%). American Society of Anesthesiologist (ASA) classification ≥3 [OR 1.565, 95% CI (1.204, 2.034), p = 0.0008] and prolonged operative time [OR 1.597, 95% CI (1.221, 2.089), p = 0.0006] were significant independent risk factors for reoperations.ConclusionsUnplanned reoperations are a useful quality indicator for MFTT. ASA classification ≥3 and prolonged operative time were risk factors associated with an increased risk for unplanned reoperations. © 2015 Wiley Periodicals, Inc. Microsurgery 37:184–189, 2017.
Multiparametric MRI analysis for the evaluation of MR‐guided high intensity focused ultrasound tumor treatment
Authors: Hectors Stefanie J. C. G. , Jacobs Igor , Heijman Edwin , Keupp Jochen , Berben Monique , Strijkers Gustav J. , Grüll Holger , Nicolay Klaas 
Published: July 2015

For the clinical application of high intensity focused ultrasound (HIFU) for thermal ablation of malignant tumors, accurate treatment evaluation is of key importance. In this study, we have employed a multiparametric MRI protocol, consisting of quantitative T1, T2, ADC, amide proton transfer (APT), T1ρ and DCE‐MRI measurements, to evaluate MR‐guided HIFU treatment of subcutaneous tumors in rats. K‐means clustering using all different combinations of the endogenous contrast MRI parameters (feature vectors) was performed to segment the multiparametric data into tissue populations with similar MR parameter values. The optimal feature vector for identification of the extent of non‐viable tumor tissue after HIFU treatment was determined by quantitative comparison between clustering‐derived and histology‐derived non‐viable tumor fractions. The highest one‐to‐one correspondence between these clustering‐based and histology‐based non‐viable tumor fractions was observed for the feature vector {ADC, APT‐weighted signal} (R2 to line of identity (R2y=x) = 0.92) and the strongest agreement was seen 3 days after HIFU (R2y=x = 0.97). To compare the multiparametric MRI analysis results with conventional HIFU monitoring and evaluation methods, the histology‐derived non‐viable tumor fractions were also quantitatively compared with non‐perfused tumor fractions (derived from the level of contrast enhancement in the DCE‐MRI measurements) and 240 CEM tumor fractions (i.e. thermal dose > 240 cumulative equivalent minutes at 43 °C). The correlation between histology‐derived non‐viable tumor fractions directly after HIFU and the 240 CEM fractions was high, but not significant. The non‐perfused fractions overestimated the extent of non‐viable tumor tissue directly after HIFU, whereas an underestimation was observed 3 days after HIFU.In conclusion, we have shown that a multiparametric MR analysis, especially based on the ADC and the APT‐weighted signal, can potentially be used to determine the extent of non‐viable tumor tissue 3 days after HIFU treatment. We expect that this method can be incorporated in the current clinical workflow of MR–HIFU ablation therapies. Copyright © 2015 John Wiley & Sons, Ltd.
Mid‐Cretaceous rudists (Bivalvia: Hippuritida) from the Langshan Formation, Lhasa block, Tibet
Authors: Rao Xin , Skelton Peter W. , Sha Jingeng , Cai Huawei , Iba Yasuhiro 
Published: July 2015

AbstractThe Cretaceous Langshan Formation, which crops out along the northern portion of the Lhasa block, is composed mainly of grey or grey‐black fine‐grained limestones, argillaceous limestones and a few thin‐bedded siltstones and silty mudstones. From specimens collected and/or photographed in the field, combined with a revision of taxa previously recorded from the Langshan Formation, four rudist taxa are recognized: (1) Auroradiolites gen. nov.; (2) Eoradiolites cf. davidsoni; (3) Magallanesia rutogensis sp. nov.; and (4) Sellaea sp. We propose Auroradiolites gen. nov. for the grouping of SW Asian to Pacific radiolitid species formerly attributed to Eoradiolites and characterized by a compact (non‐celluloprismatic) outer shell layer. The new genus is represented in the Langshan Formation by A. biconvexus (Yang et al., 1982), including several other synonymized taxa. Taxonomic confusion in the literature has resulted from the varied appearance of the strongly developed ligamentary infolding in such forms: in the right valve, it has a forked inner termination, but common transverse sections through both valves show the latter juxtaposed against its broad, rounded counterpart in the left valve, giving the combined terminations a bulb‐shaped appearance. Associated Eoradiolites cf. davidsoni is of smaller size and, by contrast, shows the celluloprismatic structure of the outer shell layer. The recently described canaliculate polyconitid genus, Magallanesia Sano et al., 2014, is represented by M. rutogensis sp. nov., which differs from the type species in possessing more numerous and ventrally extended canals in the left valve. Possibly belonging with the latter species are isolated right valves, similar to Horiopleura, but containing tabulae. A probable Sellaea sp. is represented by poorly preserved right valves nevertheless showing typical features, including a very thin outer shell layer and an erect posterior myophoral wall, separating off a broad posterior ectomyophoral cavity. Based on the presence of Magallanesia and the orbitolinid record, this rudist fauna is probably no older than late Albian, while a younger age cannot be excluded. Both Magallanesia and Auroradiolites are characteristic of a SW Asian/central Pacific faunal province, while the other two genera are more widely distributed.
Genome-Wide Identification of MESP1 Targets Demonstrates Primary Regulation Over Mesendoderm Gene Activity
Authors: Soibam Benjamin , Benham Ashley , Kim Jong , Weng Kuo-Chan , Yang Litao , Xu Xueping , Robertson Matthew , Azares Alon , Cooney Austin J. , Schwartz Robert J. , Liu Yu 
Published: July 2015

Abstract
MESP1 is considered the first sign of the nascent cardiac mesoderm and plays a critical role in the appearance of cardiac progenitors, while exhibiting a transient expression in the developing embryo. We profiled the transcriptome of a pure population of differentiating MESP1-marked cells and found that they chiefly contribute to the mesendoderm lineage. High-throughput sequencing of endogenous MESP1-bound DNA revealed that MESP1 preferentially binds to two variants of E-box sequences and activates critical mesendoderm modulators, including Eomes, Gata4, Wnt5a, Wnt5b, Mixl1, T, Gsc, and Wnt3. These mesendoderm markers were enriched in the MESP1 marked population before the appearance of cardiac progenitors and myocytes. Further, MESP1-binding is globally associated with H3K27 acetylation, supporting a novel pivotal role of it in regulating target gene epigenetics. Therefore, MESP1, the pioneer cardiac factor, primarily directs the appearance of mesendoderm, the intermediary of the earliest progenitors of mesoderm and endoderm organogenesis. Stem Cells 2015;33:3254–3265
Network planning for Type 1 and Type 1a relay nodes in LTE‐Advanced networks
Authors: Tseng Fan‐Hsun , Chou Li‐Der , Chao Han‐Chieh 
Published: July 2015

AbstractIn this paper, the planning problem of multiple evolved Node Bs (eNBs) and two types of relay nodes is defined base on linear programming. Type 1 relay nodes are placed in the center of eNB, and Type 1a relay nodes are deployed at cell edge. Three algorithms are proposed to investigate the Type 1a relay node placement and communication interference. All algorithms are designed on the basis of graph theory and analyzed in planning case and simulation results. The ultimate goal is to maximize the average throughput of all served users with minimum communication interference. Results showed that the proposed interference coordination algorithm not only provides the lowest construction cost with slightly fewer numbers of served users but also eliminates the communication interference with the highest average throughput. Most importantly, it achieves the best communication quality for next generation mobile networks. Copyright © 2015 John Wiley & Sons, Ltd.
Evaluation of a waistband for attaching external radiotransmitters to anurans
Authors: Groff Luke A. , Pitt Amber L. , Baldwin Robert F. , Calhoun Aram J. K. , Loftin Cynthia S. 
Published: July 2015

ABSTRACTRadiotelemetry provides fine‐scale temporal and spatial information about an individual's movements and habitat use; however, its use for monitoring amphibians has been restricted by transmitter mass and lack of suitable attachment techniques. We describe a novel waistband for attaching external radiotransmitters to anurans and evaluate the percentages of resulting abrasions, lacerations, and shed transmitters. We used radiotelemetry to monitor movements and habitat use of wood frogs (Lithobates sylvaticus) in 2006 and 2011–2013 in Maine, USA; American toads (Anaxyrus americanus) in 2012 in North Carolina, USA; and, wood frogs, southern leopard frogs (L. sphenocephalus), and green frogs (L. clamitans) in 2012 in South Carolina, USA. We monitored 172 anurans for 1–365 days (56.4 ± 59.4) in a single year and 1–691 days (60.5 ± 94.1) across years. Our waistband resulted in an injury percentage comparable to 7 alternative anuran waistband attachment techniques; however, 12.5% fewer anurans shed their waistband when attached with our technique. Waistband retention facilitates longer monitoring periods and, thus, provides a greater quantity of data per radiotagged individual. © 2015 The Wildlife Society.
Parental attachment and Chinese adolescents' delinquency: The mediating role of moral disengagement
Authors: Bao Zhenzhou , Zhang Wei , Lai Xuefen , Sun Wenqiang , Wang Yanhui 
Published: July 2015

AbstractThere is substantial literature documenting the negative association between secure parental attachment and lower adolescent delinquency, but little is known about the mediating mechanisms (i.e., how does parental attachment relate to delinquency?) underlying this relation. The present study examined whether secure parental attachment would be indirectly related to lower adolescent delinquency through lower adolescent moral disengagement. A total of 1766 adolescents (44% male; mean age = 14.25 years,SD= 1.54) living in an urban area of southern China completed anonymous questionnaires regarding parental attachment, moral disengagement and delinquency. After controlling for gender, age, socioeconomic status, and school variable, it was found that secure parental attachment was negatively associated with adolescent delinquency and this negative association was fully mediated by the extent of adolescent moral disengagement. These findings contribute to an understanding of the mechanisms underlying the development of adolescent delinquency and have important implications for intervention.
Brief report: Executive functions in adolescent offspring of mothers with a history of depression
Authors: Wagner Clara , Abramson Lyn Y. , Alloy Lauren B. 
Published: July 2015

AbstractDeficits in executive functions (EFs) have been documented among individuals with unipolar depression, but controversy exists as to whether such deficits are state‐dependent or are trait markers that precede disorder onset. The present study examined whether maternal history of unipolar depression was associated with deficits in EFs in early adolescent offspring, a finding that would support a trait marker conceptualization of EF deficits.Participants were a diverse sample (N = 493) of adolescents and their mothers recruited through local schools. Measures included semi‐structured diagnostic interviews of mother and adolescent, mother‐report forms assessing demographic information, and tests of executive function. Hierarchical linear regression analyses were conducted to examine the association between maternal depression diagnosis and adolescent offspring performance on tests of EF. Maternal lifetime history of depression was not associated with offspring EF task performance. Findings are not consistent with the conceptualization of impaired executive functions as trait markers of unipolar depression.
Impact of Glaucoma on Quality of Life and Activities of Daily Living
Authors: Park Sangshin , Kho Young Lim , Kim Hyo-Jin , Kim JiHyun , Lee Eun-Hee 
Published: July 2015

Objective/Background This study was performed to assess the associations of glaucoma with health-related quality of life (HRQOL) and activities of daily living (ADL). Methods Using data from the Korean National Health and Nutrition Examination Survey III in 2005, we analysed 9,047 participants (≥ 50 years old) and 3,518 participants (> 65 years old) to assess the associations of glaucoma with HRQOL and ADL, respectively. The diagnosis of glaucoma was based on questionnaires. HRQOL was evaluated by the EuroQol five-dimension descriptive system (EQ-5D) and the EuroQol visual analogue scale. The ADL was evaluated by the Korean-optimised ADL questionnaire. Logistic-regression analyses were used to assess the associations of glaucoma with HRQOL and ADL. Results The glaucoma patients showed lower HRQOL and ADL scores compared to the healthy participants. The glaucoma patients showed significantly higher prevalence of impaired health status in all dimensions of EQ-5D, as well as in the “bathing” dimension of ADL as compared with the healthy participants. Impaired HRQOL and ADL were significantly associated with the risk of glaucomatous status (odds ratio [95% confidence interval] of EQ-5D: 1.65 [1.33, 2.05], EuroQol visual analogue scale: 1.75 [1.43, 2.15], and ADL: 2.04 [1.12, 3.74]). Conclusion In line with previous studies conducted in other countries, Koreans with glaucoma had impaired HRQOL and ADL as compared with healthy Koreans.
Round robin test on quantification of amyloid‐β 1–42 in cerebrospinal fluid by mass spectrometry
Authors: Pannee Josef , Gobom Johan , Shaw Leslie M. , Korecka Magdalena , Chambers Erin E. , Lame Mary , Jenkins Rand , Mylott William , Carrillo Maria C. , Zegers Ingrid , Zetterberg Henrik , Blennow Kaj , Portelius Erik 
Published: July 2015

AbstractIntroductionCerebrospinal fluid (CSF) amyloid‐β 1–42 (Aβ42) is an important biomarker for Alzheimer's disease, both in diagnostics and to monitor disease‐modifying therapies. However, there is a great need for standardization of methods used for quantification. To overcome problems associated with immunoassays, liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) has emerged as a critical orthogonal alternative.MethodsWe compared results for CSF Aβ42 quantification in a round robin study performed in four laboratories using similar sample preparation methods and LC‐MS instrumentation.ResultsThe LC‐MS results showed excellent correlation between laboratories (r2 >0.98), high analytical precision, and good correlation with enzyme‐linked immunosorbent assay (r2 >0.85). The use of a common reference sample further decreased interlaboratory variation.DiscussionOur results indicate that LC‐MS is suitable for absolute quantification of Aβ42 in CSF and highlight the importance of developing a certified reference material.