bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Literature Review: Media Pembelajaran Berbasis Android Untuk Memfasilitasi Kemampuan Pemahaman Konsep Matematis
Authors: Nur'aini Fatma Azzahra , Nurul Arfinanti  
Published: July 2024

Kemajuan teknologi memudahkan bidang pendidikan terutama pada proses pembelajaran. Keefektifan pembelajaran dapat tercapai melalui inovasi dalam pembelajaran, salah satunya adalah memanfaatkan media pembelajaran digital. Aplikasi Android menjadi alternatif media untuk membangkitkan motivasi dalam memahami materi. Penelitian ini bertujuan untuk melakukan kajian literatur artikel terdahulu tentang penggunaan media pembelajaran berbasis Android untuk memfasilitasi kemampuan pemahaman konsep peserta didik. Metode yang digunakan adalah Systematic Literature Review. Pengumpulan data dilakukan dengan menelaah dan mereviw artikel-artikel terkait media pembelajaran berbasis Android dalam memfasilitasi pemahaman konsep yang dipublikasikan dalam rentang waktu 2019-2024. Terdapat 15 artikel jurnal nasional dan prosiding seminar yang digunakan dalam penelitian ini, yang diperoleh melalui Google Scholar. Berdasarkan penelitian ini diperoleh hasil bahwa penggunaan media pembelajaran berbasis Android dapat memfasilitasi pemahaman konsep matematika dan memberikan dampak positif pada pembelajaran matematika.
Characterization and Animal Skin Irritations Investigation of Vemurafenib Microemulsion-Based Hydrogel Using Oily Ionic Liquid
Authors: J. Neamah Mohammed , J. Al- Akkam Entidhar 
Published: July 2024

Cutaneous melanoma accounts for a yearly mortality rate of 55,500 persons. The use of oral small-molecule kinase inhibitors, specifically targeting BRAFv600, has been licensed as the principal treatment strategy for managing both locally progressed and metastatic presentations of the condition. Approximately 30% of people on vemurafenib, a BRAFv600 inhibitor, have side effects when are taken orally. Objective: This research was attempted to develop a vemurafenib microemulsion by substituting conventional oil phases with ionic liquids (ILs). The microemulsions were created by dissolving vemurafenib in a combination of ionic liquid (1-Butyl-3-methylimidazolium hexafluorophosphate and 1-Octyl-3-methylimidazolium hexafluorophosphate) and surfactant (Triton x-100). Multiple tests were conducted to measure physical stability, pH determination, content homogeneity examination, and in vitro medicine release analysis. Four formulations of Vemurafenib microemulsions successfully met all criteria in the microemulsion characterisation and assessment tests. The droplet sizes in these microemulsions fell inside the range of microemulsions, which is less than 200 nm. They were then used to create microemulsion-based hydrogels, employing Carbamer 340 as a gelling agent by conducting a simple mixing method. Hydrogels formed from microemulsions containing 1-Octyl-3-methylimidazolium hexafluorophosphate demonstrated the ability to form clear hydrogels with desirable consistency. Regarding Ex-vivo permeability study and skin deposition the permeability profiles of GOT3 formula exhibits a permeability measurement of 33569± 344 mP.s at 6 rpm, whereas GOT4 demonstrates a permeability measurement of 54723± 380 mP.s at 6 rpm. During the skin irritation test, there was no apparent erythema and edema were observed when compared to the negative group. This may indicate that the designed microemulsion-based gel formulation demonstrates good biocompatibility with skin tissue. Topical delivery of vemurafenib is a promising route of drug administration to melanoma skin. Ionic liquids (ILs) have permeation-enhancing properties with either hydrophilic or lipophilic characteristics‎‎‎‎‎.
The scholia on Hecuba in the Comnenian Age: codices Vat. Gr. 1135 and Vat. Ott. Gr. 339
Authors: Cavarzeran Jacopo 
Published: July 2024

The paper examines the text of the scholia, mostly non yet edited, on Euripides’ Hecuba in the manuscript Vat. gr. 1135 and its apographon, with the aim of placing it within the textual tradition. The analysis of some scholia allows ascribing the most part of this material to the scholarly exegesis of the twelfth century, shedding light on the state of the Euripidean scholia after the eleventh century, which is the period to which the veteres manuscripts date back, but before the Palaeologan age.
Hermagoras of Temno and the ‘Commonplaces’ (T 17 Woerther)
Authors: Pirovano Luigi 
Published: July 2024

This paper offers a new interpretation of a passage from Theon’s progymnasmatic manual (120.13‑20 Sp.), which is traditionally included among Hermagoras of Temnos’ ‘fragments’ (T 17 W.). Based on the text preserved by Theon’s Armenian tradition and on the comparison with the parallel sources, the following conclusions can be drawn: (a) the ‘fragment’ consists of two sections, which must be considered separately; (b) while the first part can be prudently linked to Hermagoras of Temnos only, the second one is certainly attributable to him and – if correctly contextualised – may reveal some interesting details about his theory of argumentation.
MEKANISME BONUS DAN TUNNELING INCENTIVE TERHADAP PRAKTIK TRANSFER PRICING EFEK MODERASI TAX AVOIDANCE
Authors: Nuraisah Nuraisah , Amanda Reydina Pasya , Rambe Salsabila , Batubara Maryam 
Published: July 2024

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh mekanisme bonus dan tunneling incentive terhadap praktik transfer pricing dengan pengungkapan tax avoidance sebagai moderasi. Penelitian ini menggunakan sampel perusahaan IDX Growth 30 pada tahun 2017-2022. Metode penelitian ini adalah sampling jenuh, dan diperoleh 30 perusahaan yang dijadikan sampel penelitian dengan pengamatan selama 6 (enam) tahun, sehingga total data observasi adalah sebanyak 180 perusahaan. Metode analisis yang digunakan yaitu analisi statistic deskriptif dan analisis regresi data panel . Hasil penelitian ini menunjukan bahwa mekanisme bonus berpengaruh negatif terhadap praktik transfer pricing, tunneling incentive tidak berpengaruh terhadap praktik transfer pricing sedangkan mekanisme bonus dan tunneling incentive secara simultan berpengaruh terhadap praktik transfer pricing. Tax avoidance mampu memoderasi mekanisme bonus dan tunneling incentive terhadap praktik transfer pricing.
Minimally invasive methods of treatment of single recurrent metastases in the lymph nodes of the neck of highly differentiated thyroid cancer
Authors: Tovkai O. A. , Palamarchuk V. O. , Lishchynskyi P. O. , Stotska L. V. , Yatsiv A. R. , Vovk E. O. 
Published: July 2024

Papillary thyroid cancer is the most common type of cancer, which accounts for about 80—85% of malignant tumors of this organ. In 20—30% of patients, a relapse of the disease is detected after treatment. Repeated surgical intervention increases the likelihood of complications. Minimally invasive techniques give the possibility of effective ablation of individual metastases of the neck less traumatically and with lower costs.
Objective — to evaluate the effectiveness of minimally invasive treatment methods of isolated recurrent metastases of highly differentiated thyroid cancer.
Materials and methods. The study involved 34 patients with recurrent metastases of papillary thyroid cancer in neck lymph nodes. Patients were allocated into two groups depending on the use of minimally invasive methods: 31 underwent percutaneous ethanol sclerotherapy, three patients underwent laser‑induced interstitial thermotherapy. All patients underwent volume treatment: thyroidectomy, central and lateral neck dissection, lymphadenectomy followed by radioiodine therapy. Patients had solitary altered lymph nodes, metastases size <1.5 cm3, at a safe distance from main vessels, trachea, or esophagus, high risk of postoperative complications, and/or refused repeated surgical intervention.
Results. Percutaneous ethanol sclerotherapy technique in 28 patients resulted in the decrease in thyroglobulin levels by 33.6% at average; antibodies to thyroglobulin by 15.3%, and remission of the disease, according to ultrasound results. In three patients, the growth of a metastatic lymph node with an increase in the level of thyroglobulin was noted, which indicates that the described method wasn’t sufficiently effective. The laser‑induced interstitial thermotherapy procedure was performed only in three patients, this small group does not allow conducting a reliable analysis of the treatment results. Positive clinical, laboratory and pathomorphological effect was obtained in all three cases.
Conclusions. Minimally invasive techniques have no sufficient effectiveness in comparison with surgery, but they are effective enough for patients with a high risk of postoperative complications, anesthetic risk, and/or for those who refused to undergo repeated surgery.
Thyroid hormone receptor-beta agonists in the treatment of metabolically associated steatotic liver disease. Review
Authors: Tkach S. M. , Yuzvenko T. Y. , Pankiv V. I. , Chyrkov Y. E. , Dogotar V. B. 
Published: July 2024

Metabolic dysfunction-associated steatotic liver disease, or metabolically-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease, has become the leading chronic liver disease worldwide in the last decade. The spectrum of MASLD ranges from simple hepatic steatosis to metabolic-associated steatohepatitis (MASH), advanced liver fibrosis, liver cirrhosis, and hepatocellular carcinoma. Hepatic inflammation and progressive fibrosis are considered to be the most important driving forces for the progression of MASLD/MASH. Therefore, patients with MASH are a key target group for the development of new therapeutic agents. Although many clinical trials have been conducted in patients with MASLD/MASH over the past two decades, until recently there was no licensed drug for the treatment of this very common metabolic liver disease. Preclinical experimental studies and results from human studies have confirmed the importance of thyroid hormone receptor-β (TGR-β) in the development of hepatic steatosis and stimulated interest in the development of TGR-β agonists as potential treatments for MASLD. The effects of TGR-β agonists, mainly resmetirom, on hepatic and cardiometabolic risk factors have been tested in randomized placebo-controlled trials (RCTs) in patients with MASLD/MASH. As a result of the positive data obtained in the phase III RCT (MAESTRO-NASH), the USA FDA agency on March 14, 2024 accelerated approval of the first TGR-β agonist resmetirom as a drug for the treatment of steatohepatitis associated with metabolic dysfunction. Thus, resmetirom has become the first officially approved drug to be recommended in combination with diet and exercise for use in adults with non-cirrhotic MASH with moderate or advanced liver fibrosis (stages F2-F3 fibrosis).
Prognostic factors for the development of obstetric and perinatal pathology in pregnant women under conditions of iodine deficiency
Authors: Paienok O. S. , Soloshchenko V. I. , Hrytsyshyn B. R. , Ignatovych S. V. 
Published: July 2024

According to the World Health Organization (WHO), iodine deficiency is the main cause of mental retardation in children, and at the same time, it significantly affects the pathological course of pregnancy and childbirth. The problem is complicated by the fact that more than 100.000 children with cretinism are born annually in the world. In recent years, there has been a significant increase in endemic thyroid diseases in Ukraine, the main cause of which is insufficient iodine consumption. Iodine deficiency conditions are aggravated by socio‑economic, ecological and radiological factors, while at the same time mass and group iodine prophylaxis is carried out improperly on the state level.
Objective. To determine prognostic factors for the development of obstetric and perinatal pathology in pregnant women under conditions of iodine deficiency.
Materials and methods. To compile a diagnostic table of prognostic factors of the threat of miscarriage, the analysis has been performed of 185 cases of threatened abortion (111 in the first trimester, 56 in the second, 18 in the third) and 223 control observations (without the threat of miscarriage). A diagnosis was considered as confirmed if it was established using all applicable methods of examination of pregnant women.
Results. The risk factors of the occurrence of perinatal pathology include hypothyroxinemia (DC=–2.5) and ioduria in pregnant women less than 100 mg/l (DC=–1.9). In the intranatal period, a negative impact is exerted by the lack of coordination and weakness of labor activity (DC=–8.1). Levels of thyroid‑stimulating hormone (TSH) in umbilical cord blood >10 mIU/ml (DC=–4.6) are the prognostically favorable factors for the postnatal adaptation of the newborn, especially TSH levels >20 mIU/ml (DC=–8.3). Conduction of iodine prophylaxis (DC=7.7) and ioduria in pregnant women 200—400 mg/l (DC=5.1) contribute to the improvement of perinatal outcomes.
Conclusions. A retrospective review of the prognostic significance of the diagnostic table in 188 patients with diffuse nontoxic goiter revealed its sensitivity (76%) and specificity (68%). On the basis of the conducted research, we established risk factors for the development of obstetric and perinatal complications, and assessed their informativeness. The developed algorithm is represented by a diagnostic table for the prediction of complications of pregnancy, childbirth and adverse perinatal outcomes in women with endemic thyropathies.
Sleep disorders and diabetes mellitus. Literature review and own data
Authors: Urbanovych A. M. , Shykula S. I. 
Published: July 2024

The article presents analysis of current research on sleep disorders in patients with type 2 diabetes mellitus (T2DM). The mechanisms underlying the relationship between insomnia and glycemic control are complex, as both DM can cause sleep disorders and insomnia can worsen the course of diabetes. It is well known that both short (< 6 hours) and long (> 8 hours) sleep durations are associated with an elevated risk of diabetes development. The reported prevalence of sleep disorders in diabetes patients ranges between 28.0% and 59.1%. Our investigation performed in Lviv with the use of Pittsburgh Sleep Quality Index (PSQI) questionnaire, identified that 46.2% of T2DM patients experienced sleep disorders. A comprehensive literature review also unveils association between DM and diverse sleep disorders such as insomnia, circadian rhythm disturbances, obstructive sleep apnea (OSA), and restless legs syndrome (RLS). The article furnishes insights into the classification, diagnostic principles, and treatment modalities for these disorders. Referral of patients to sleep specialists for the management of sleep disorders and the integration of sleep hygiene into diabetes care can effectively mitigate symptoms, forestall DM complications, and enhance patients’ quality of life. Circadian molecules like nobiletin, REV‑ERB agonists, and CRY stabilizers have demonstrated efficacy in preclinical studies and hold potential for the development of novel treatments for conditions associated with circadian dysregulation. Considering the frequency of detection of sleep disorders in T2DM patients according to the modern literary sources and own research, the study of this problem is important for the development of an algorithm for the examination of such patients, namely the need for endocrinologists to pay attention to the sleep status of patients and, if necessary, to refer them to somnologists. Further investigation into the etiology of sleep disorders in T2DM patients and their correlation with carbohydrate metabolism indicators exhibits promise. It is imperative to explore avenues to address these causes by complementing the primary therapy for T2DM.
LOS PRINCIPIOS Y GARANTÍAS DE LA MEDIACIÓN EN LA LEY 10543 Y EN LA NORMATIVA DICTADA DURANTE LA PANDEMIA
Authors: Campodónico Manuel 
Published: July 2024

El presente trabajo analiza en profundidad los principios y garantías contenidos en la ley provincial de mediación 10543 (Córdoba, 2018) a partir de los aportes teóricos de distintos autores, identificando tanto aquellos que fueron introducidos por la nueva normativa como aquellos que ya estaban presentes en la anterior ley 8858. Además, hace una revisión de la nueva normativa dictada a partir de la pandemia Covid-19, que implementa protocolos de actuación en la virtualidad tanto para los Centros Judiciales de Mediación (Acuerdos reglamentarios 1625 y 1643 del Tribunal Superior de Justicia) como para centros públicos y privados (Resoluciones 02/20 y 03/20 de la Secretaría de Justicia), indagando sobre sus impactos sobre los principios previamente relacionados.
SUCESION INTERNACIONAL
Authors: Assandri Mónica 
Published: July 2024

El presente trabajo pretende abordar el examen de la competencia internacional y su extensión cuando se abren procesos sucesorios por la sola circunstancia de la existencia de bienes inmuebles situados en el país. Al respecto el Código Civil y Comercial de la Nación (en adelante CCyC) establece en el art. 2643 como principio general que dicha competencia le viene asignada a los jueces argentinos por el último domicilio del causante o por el lugar de situación de bienes inmuebles en el país, respecto de éstos. En otras palabras, ello significa que los jueces argentinos tendrán competencia si los inmuebles se encuentran situados en nuestro territorio, pero solamente podrán entender en la sucesión respecto de ellos, si el domicilio del causante se hallaba en el extranjero. En este contexto, se afirma que la jurisdicción en CCyC no corresponde única y exclusivamente a los jueces del último domicilio del cujus, sino que se consagra el criterio del foro patrimonial, reconociendo el criterio doctrinal y jurisprudencial imperante en el tema.
LA AUSENCIA DE LO NECESARIO TRANSPORTE, COMERCIO EXTERIOR, TURISMO Y DERECHO ADUANERO EN LA FORMACIÓN DEL ABOGADO
Authors: Javurek Giselle 
Published: July 2024

En septiembre de 2017, por Resolución N° 3401-E2017, el Ministerio de Educación de la Nación aprobó los contenidos curriculares mínimos de la Carrera de Abogacía, en miras a la primera convocatoria para acreditar la misma por ante la Comisión Nacional de Evaluación y Acreditación Universitaria (CONEAU) y que se concretara el 18 de diciembre de ese mismo año. Sorprendentemente,la temática base del presente trabajo, es decir, transporte, comercio exterior, turismo y derecho aduanero, se encuentra ausente de lo exigido para otorgar el título de abogado en nuestro país, a pesar de las innumerables situaciones que se presentan en el ejercicio de la profesión y que requieren el conocimiento de normativa específica.
LA JURISDICCIÓN CONTENCIOSO ADMINISTRATIVA EN LA PROVINCIA DE CÓRDOBA COMO JURISDICCIÓN CONSTITUCIONAL
Authors: Sosa Daniela Susana 
Published: July 2024

En Córdoba, tras la reforma introducida a la Ley General de Amparo -Ley 4915- a través de las leyes 10249 y 10323, se ratificó la existencia de una jurisdicción constitucional cuya finalidad es garantizar la protección de los derechos fundamentales frente a toda actividad u omisión estatal. La atribución de la intervención de una justicia especializada en todos los procesos de amparos interpuestos en contra de la administración pública provincial, municipal o comunal en el ámbito de la Provincia, configura una jurisdicción contencioso administrativo moderna y acorde a las directrices constitucionales y convencionales que tutelan los derechos de los ciudadanos. Un recorrido por los antecedentes legislativos provinciales y los casos jurisprudenciales resueltos por el Tribunal Superior de Justicia de Córdoba, dan razón a la decisión acertada del legislador provincial de recurrir a un modelo mixto de distribución de competencias en materia de amparos, donde además del carácter de sujeto público del demandado, el contenido de la pretensión y la preeminencia del régimen de derecho público aplicable, condicionan la asignación de competencia al fuero especializado.
Metallurgical Fundamentals of Quenching
Authors: Lozano Diego E. , Martínez-Cázares Gabriela M. , Bedolla-Gil Yaneth 
Published: July 2024

Abstract
Steels are among the most versatile materials in modifying their microstructure and properties by heat treatment. This article outlines the basic concepts of physical metallurgy relating to the heat treatment of steel. It considers the phases and microstructures of steel together with the transformations observed and critical temperatures during heat treatment. Additionally, the different types of steels, heat treatments, and their purposes are also discussed.
Hardenability of Steels and Cast Irons
Authors: Canale Lauralice C.F. , Albano Luigi L.M. , Zordao Luís H.P. , Totten George E. 
Published: July 2024

Abstract
Hardening and depth of hardening of steel is a critically important material and process design parameter. This article presents a selective overview of experimental and predictive procedures to determine steel hardenability. It also covers the breadth of steel hardenability, ranging from shallow, to very difficult to harden, to air-hardening steels.
Nanofluid Quench Media for Industrial Heat Treatment
Authors: Samuel Augustine , Prabhu K. Narayan 
Published: July 2024

Abstract
This article details investigations on the characterization of various nanofluids as quenchants for industrial heat treatment. It provides a discussion on the preparation, stability, thermophysical properties, and wetting characteristics of nanofluids. The article explains the mechanism of heat transfer in nanofluids and discusses the effect of the deposition of nanoparticles on the probe surface. The article also presents the microstructure and mechanical properties of steel quenched in nanofluids.
Development of Teamwork Competencies among Students in Project Activity
Authors: Adzhieva Elena Mikhailovna , Petrenko Antonina Anatolyevna 
Published: July 2024

In line with the Federal State Educational Standard, the university incorporates requirements for developing universal competencies, such as program design, teamwork, and leadership skills. Fostering teamwork competencies through project activities aligns with the university's goals for modern education. The importance of this issue is underscored by the introduction of new disciplines on project activities and teamwork, aiming to enhance pedagogical practices. The study aimed to assess students' teamwork competence levels essential for their professional and personal lives, and to provide recommendations for its development. Research methods included theoretical analysis and practical surveys of 214 students from the 2nd-5th courses at S.A. Yesenin Russian State University. The results highlighted students' readiness for teamwork based on their values. While various team-building activities are recognized, there is a lack of clear value orientations driving real-world teamwork. The findings emphasize the need to enhance educational processes, teaching methods, and curriculum content in this area.