bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of thresholds and a visualization tool for use of a blood test in routine clinical dementia practice
Authors: Verberk Inge M. W. , Jutte Jolien , Kingma Maurice Y. , Vigneswaran Sinthujah , Gouda Mariam M. T. E. E. , van Engelen Marie‐Paule , Alcolea Daniel , Arranz Javier , Fortea Juan , Lleó Alberto , Chevalier Claire , Marizzoni Moira , van de Giessen Elsmarieke M. , Lemstra Afina W. , Pijnenburg Yolande A. L. , van der Flier Wiesje M. , den Braber Anouk , Wilson David , Schut Martijn C. , van Harten Argonde C. , Teunissen Charlotte E. 
Published: August 2024

AbstractINTRODUCTIONWe developed a multimarker blood test result interpretation tool for the clinical dementia practice, including phosphorylated (P‐)tau181, amyloid‐beta (Abeta)42/40, glial fibrillary acidic protein (GFAP), and neurofilament light (NfL).METHODSWe measured the plasma biomarkers with Simoa (n = 1199), applied LASSO regression for biomarker selection and receiver operating characteristics (ROC) analyses to determine diagnostic accuracy. We validated our findings in two independent cohorts and constructed a visualization approach.RESULTSP‐tau181, GFAP, and NfL were selected. This combination had area under the curve (AUC) = 83% to identify amyloid positivity in pre‐dementia stages, AUC = 87%–89% to differentiate Alzheimer's or controls from frontotemporal dementia, AUC = 74%–76% to differentiate Alzheimer's or controls from dementia with Lewy bodies. Highly reproducible AUCs were obtained in independent cohorts. The resulting visualization tool includes UpSet plots to visualize the stand‐alone biomarker results and density plots to visualize the biomarker results combined.DISCUSSIONOur multimarker blood test interpretation tool is ready for testing in real‐world clinical dementia settings.Highlights
We developed a multimarker blood test interpretation tool for clinical dementia practice.
Our interpretation tool includes plasma biomarkers P‐tau, GFAP, and NfL.
Our tool is particularly useful for Alzheimer's and frontotemporal dementia diagnosis.
Guidelines for quantifying leaf chlorophyll content via non‐destructive spectrometry
Authors: Chiarenza Giancarlo M. , Slavich Eve , Moles Angela T. 
Published: August 2024

AbstractPremiseLeaf chlorophyll is a fundamental bioindicator used in several fields; however, we lack clear guidelines for optimizing sampling efforts and producing comparable studies.MethodsWe estimated the leaf chlorophyll content of 10 plant species using nondestructive spectrometry methods. We stored half of the leaves at 4°C and half at room temperature under similar light levels to assess the role of storage in the chlorophyll degradation rate.ResultsThe chilled mature leaves maintained a chlorophyll content within 5% of the original value for ~1.5 d, while the chlorophyll content of unrefrigerated mature leaves decreased rapidly, indicating that their chlorophyll content should be measured within 4 h. When refrigerated, the chlorophyll content of the expanding leaves remained within 5% of the original level for at least 5 d, but we suggest analyzing them within 3 d. In mature leaves, 73% of the variation in chlorophyll content is at the species level, 15% is between individuals, and the variation within leaves is negligible (<1%). Measuring one mature leaf from eight individuals was sufficient to provide a species chlorophyll estimate within 5% of the true value at least 80% of the time.DiscussionWe advise researchers to prioritize sampling more individuals rather than repeating measures within leaves or individuals. Our findings will help researchers to optimize their time and research efforts, and to obtain more robust ecological data.
Temperature and humidity as drivers for the transmission of zoonotic diseases
Authors: Zhang Li , Lv Chenrui , Guo Wenqiang , Li Zhenzhuo 
Published: August 2024

AbstractZoonotic diseases remain a persistent threat to global public health. Many major zoonotic pathogens exhibit seasonal patterns associated with climatic variations. Quantifying the impacts of environmental variables such as temperature and humidity on disease transmission dynamics is critical for improving prediction and control measures. This review synthesizes current evidence on the relationships between temperature and humidity and major zoonotic diseases, including malaria, dengue, rabies, anisakiasis, and influenza. Overall, this review highlighted some overarching themes across the different zoonotic diseases examined. Higher temperatures within suitable ranges were generally associated with increased transmission risks, while excessively high or low temperatures had adverse effects. Humidity exhibited complex nonlinear relationships, facilitating transmission in certain temperature zones but inhibiting it in others. Heavy rainfall and high humidity were linked to vector‐borne disease outbreaks such as malaria by enabling vector breeding. However, reduced incidence of some diseases like dengue fever was observed with high rainfall. To address existing knowledge gaps, future research efforts should prioritize several key areas: enhancing data quality through robust surveillance and the integration of high‐resolution microclimate data; standardizing analytical frameworks and leveraging advanced methodologies such as machine learning; conducting mechanistic studies to elucidate pathogen, vector, and host responses to climatic stimuli; adopting interdisciplinary approaches to account for interacting drivers; and projecting disease impacts under various climate change scenarios to inform adaptation strategies. Investing in these research priorities can propel the development of evidence‐based climate‐aware disease prediction and control measures, ultimately safeguarding public health more effectively.
Best practices for user consultation in flow cytometry shared resource laboratories
Authors: Asosingh Kewal , Bayiyana Alice , Black Michele C. , Chakraborty Uttara , Clemente Michael J. , Graham Amy C. , Gregory Michael D. , Hogg Karen G. , Van Isterdael Gert , Liu ChunChun , Martínez Lola , Petersen Charlotte C. , Porat Ziv , Price Kylie M. , Prickett Laura B. , Rieger Aja M. , Roe Caroline E. , Smit Erica 
Published: August 2024

AbstractThis “Best Practices in User Consultation” article is the result of a 2022 International Society for the Advancement of Cytometry (ISAC) membership survey that collected valuable insights from the shared research laboratory (SRL) community and of a group discussion at the CYTO 2022 workshop of the same name. One key takeaway is the importance of initiating a consultation at the outset of a flow cytometry project, particularly for trainees. This approach enables the improvement and standardization of every step, from planning experiments to interpreting data. This proactive approach effectively mitigates experimental bias and avoids superfluous trial and error, thereby conserving valuable time and resources. In addition to guidelines, the optimal approaches for user consultation specify communication channels, methods, and critical information, thereby establishing a structure for productive correspondence between SRL and users. This framework functions as an exemplar for establishing robust and autonomous collaborative relationships. User consultation adds value by providing researchers with the necessary information to conduct reproducible flow cytometry experiments that adhere to scientific rigor. By following the steps, instructions, and strategies outlined in these best practices, an SRL can readily tailor them to its own setting, establishing a personalized workflow and formalizing user consultation services. This article provides a pragmatic guide for improving the caliber and efficacy of flow cytometry research and aggregates the flow cytometry SRL community's collective knowledge regarding user consultation.
A modified Koch‐snowflake monopole antenna for short‐range radio frequency identification reader and C band applications
Authors: Das Tanmaya Kumar , Dwivedy Biswajit , Behera Santanu Kumar 
Published: August 2024

SummaryIn this research work, the design and analysis of a compact microstrip antenna having a monopole structure with 64.86% of wide bandwidth is presented. The main radiator of the structure is a fractal‐based geometry with the shape of a half‐Koch snowflake, and the ground plane is partial (defected ground). The design methodology of the antenna is presented using analytical modeling, and the structure prototype is fabricated to verify the performance. Measurement outcomes confirm the −10 dB bandwidth in range of 4–7.84 GHz, thus covering approximately the C‐band with omnidirectional radiation patterns. The proposed antenna shows a peak realized gain of 3.4 dBi at 7.2 GHz and has an overall dimension of 0.33λ × 0.49λ × 0.03λ, at 5.8 GHz. The structure is found compact compared to some recently reported designs and the read range is found to be 1.98 cm at 5.8 GHz. The read range and validation of the propagation test indicate the suitability of the compact and wideband planar antenna in various short‐range reader applications.
On the performance of multiple‐IRS aided wireless networks over Nakagami‐m fading channels
Authors: Hindustani R. K. , Dixit Dharmendra , Sharma Sanjeev 
Published: August 2024

SummaryMultiple intelligent reflecting surfaces (IRS) in a wireless system are considered to enhance performance, efficiency, and flexibility in wireless networks. In this paper, we analyze outage probability (OP) for multiple IRS panels‐assisted wireless systems over Nakagami‐
fading channels. We focus on selecting the best IRS panel to maintain the quality of service and enhance the user experience. We derive two closed‐form OP expressions using the central limit theorem and Laguerre series expansion. Additionally, we develop a novel asymptotic OP expression and obtain a novel diversity order. The diversity order of the considered system model depends on the minimum fading parameter (
) between the transmitter‐IRS panel and IRS panel‐receiver links and the number of IRS panels. We thoroughly investigate the impact of system parameters and validate our analytical results with simulations. Our findings emphasize that diversity order depends on the minimum fading parameter (
) between the transmitter‐IRS panel and IRS panel‐receiver links, the number of IRS elements in each panel, and the number of IRS panels.
Hydrocortisone treatment as a tool to study conjunctival placode induction
Authors: Drake Paige M. , Franz‐Odendaal Tamara A. 
Published: August 2024

AbstractBackgroundConjunctival placodes are a series of placodes that develop into the conjunctival (scleral) papillae and ultimately induce a series of scleral ossicles in the eyes of many vertebrates. This study establishes a hydrocortisone injection procedure (incl. dosage) that consistently inhibits all conjunctival papillae in the embryonic chicken eye. The effects of this hydrocortisone treatment on apoptosis, vasculature, and placode‐related gene expression were assessed.ResultsHydrocortisone treatment does not increase apoptotic cell death or have a major effect on the ciliary artery or vascular plexus in the eye. β‐catenin and Eda expression levels were not significantly altered following hydrocortisone treatment, despite the absence of conjunctival papillae. Notably, Fgf20 expression was significantly reduced following hydrocortisone treatment, and the distribution of β‐catenin was altered.ConclusionsOur study showed that conjunctival papillae induction begins as early as HH27.5 (E5.5). Hydrocortisone treatment reduces Fgf20 expression independently of β‐catenin and Eda and may instead affect other members of the Wnt/β‐catenin or Eda/Edar pathways, or it may affect the ability of morphogens to diffuse through the extracellular matrix. This study contributes to a growing profile of gene expression data during placode development and enhances our understanding of how some vertebrate eyes develop these fascinating bones.
Nutritional analysis of vegan recipes: From social media to plate
Authors: Yoldaş Tuba , Kaya Gözde Sultan , Parmaksız Ayhan , Işıklar Handan , Günalan Elif 
Published: August 2024

AbstractThe study aimed to determine the nutritional composition of vegan recipes shared on the Instagram social media platform and to compare these ingredients with their non‐vegan/omnivorous versions. Turkish and English vegan recipes of meatballs (n = 53), burgers (n = 12), pizza (n = 15), pasta (n = 38), cake (n = 58), and cookies (n = 52) were obtained from Instagram. They all met the criteria of being shared as #vegan labeled, presented detailed information about ingredients, and only included plant‐based ingredients. Afterward, non‐vegan/omnivorous recipes (n = 228) were determined as equivalent to the vegan recipes in each food group, and a total of 456 recipes were evaluated. The amounts of macro‐ and micronutrients per 100‐gram serving were obtained by the Nutritional Data System (BeBiS). According to the outcomes, the most significant differences in nutritional composition were found between vegan and non‐vegan meatball recipes. The levels of cholesterol and B12 were significantly lower in English vegan recipes of meatballs, pasta, cake, and cookies compared to their non‐vegan versions (p < .05). Consuming different vegan foods throughout the day could provide complementary nutrient intake and sustainable optimal health. Nevertheless, recipe‐based updates could be an innovative approach in future vegan studies. In addition, analysis of vegan recipes could be considered to modulate vegan supplementation programs.
Prognostic value of the “dynamic” R2‐ISS in patients with multiple myeloma undergoing anti‐CD38 antibody‐based triplet therapies
Authors: Kikuchi Taku , Oda Yuki , Kondo Ukyo , Tsukada Nobuhiro , Kunisada Kodai , Matsumoto Chiaki , Nomura‐Yogo Moe , Sato Kota , Takei Tomomi , Ogura Mizuki , Abe Yu , Suzuki Kenshi , Hosoya Osamu , Ishida Tadao 
Published: August 2024

AbstractTo retrospectively analyze whether the second revision of the international staging system (R2‐ISS) influenced prognosis at treatment initiation in patients with multiple myeloma (MM) receiving anti‐CD38 antibody‐based triplet treatments. High‐risk chromosomal abnormalities were examined from diagnosis to treatment initiation and considered positive if detected once. R2‐ISS was recalculated at the initiation of treatment and defined as “dynamic R2‐ISS." Data from 150 patients who underwent the defined treatments were analyzed. The median progression‐free survival (PFS) was 19.5 months, and the median overall survival (OS) was 36.5 months. Dynamic R2‐ISS significantly stratified prognoses for both PFS and OS. The median PFS for patients with dynamic R2‐ISS IV was 3.3 months, and the median OS was 11.7 months, indicating extremely poor outcomes. Although the Revised International Staging System (R‐ISS) calculated at the initiation of treatment significantly stratified treatment outcomes, the patients classified as R‐ISS could be further stratified by R2‐ISS to provide better prognostic information. Dynamic R2‐ISS showed potential as a prognostic tool in patients with MM who are treated with anti‐CD38 antibody‐based triplet therapies.
Implementing a real‐time patient experience feedback in inpatient rehabilitation: Process evaluation informed by the normalisation process theory
Authors: Struhar Jan , Walters Taylor , Gracz Kristen , Sheth Mansi , Fernandez Andrea , Lopez Courtney , Jesus Tiago S. 
Published: August 2024

AbstractPurposeNear real‐time patient experience feedback (NRTPEF) can enable a patient‐centric, immediate service recovery but has not been widely used in inpatient rehabilitation. We 1) assess the utility, feasibility, and acceptability of implementing a new NRTPEF, perceived by patients and providers; and 2) understand how the NRTPEF became embedded into routine provider practices.Materials and MethodsMixed methods process evaluation of the 8‐month implementation of an innovative NRTPEF in an inpatient rehabilitation unit, using interviews and focus groups with all the service‐unit leaders and interviews with a randomised sample of patients. Beyond descriptive statistics and content analysis, the Normalisation Process Theory (NPT) informed a framework analysis.ResultsPatients and service‐unit leaders perceived high utility in the NRTPEF (median: 9 for both; 0–10 scale) and qualitative comments emphasised the value of providing/obtaining timely feedback. The system was found feasible and acceptable for patients (median: 9.5), but with an improvement margin for providers (median: 7.3). Suggestions include strengthening the data‐relay format. Even in the pilot form, providers found the NRTPEF became embedded into practice (median 10; average: 8.6). The analysis based on the NPT shows how providers saw differential value, engaged with, and used the patient feedback into reconfigured practices.ConclusionAn innovative NRTPEF was found useful, feasible and acceptable, but with refinement opportunities before scale‐up.
The mortality burden of cachexia or weight loss in patients with colorectal or pancreatic cancer: A systematic literature review
Authors: Dunne Richard F. , Crawford Jeffrey , Smoyer Karen E. , McRae Thomas D. , Rossulek Michelle I. , Revkin James H. , Tarasenko Lisa C. , Bonomi Philip D. 
Published: August 2024

AbstractCancer‐associated cachexia is a multifactorial wasting disorder characterized by anorexia, unintentional weight loss (skeletal muscle mass with or without loss of fat mass), progressive functional impairment, and poor prognosis. This systematic literature review (SLR) examined the relationship between cachexia and survival in patients with colorectal or pancreatic cancer in recent literature. The SLR was conducted following PRISMA guidelines. Embase® and PubMed were searched to identify articles published in English between 1 January 2016 and 10 October 2021 reporting survival in adults with cancer and cachexia or at risk of cachexia, defined by international consensus (IC) diagnostic criteria or a broader definition of any weight loss. Included publications were studies in ≥100 patients with colorectal or pancreatic cancer. Thirteen publications in patients with colorectal cancer and 13 with pancreatic cancer met eligibility criteria. Included studies were observational and primarily from Europe and the United States. Eleven studies (42%) reported cachexia using IC criteria and 15 (58%) reported any weight loss. An association between survival and cachexia or weight loss was assessed across studies using multivariate (n = 23) or univariate (n = 3) analyses and within each study across multiple weight loss categories. Cachexia/weight loss was associated with a statistically significantly poorer survival in at least one weight loss category in 16 of 23 studies that used multivariate analyses and in 1 of 3 studies (33%) that used univariate analyses. Of the 17 studies demonstrating a significant association, 9 were in patients with colorectal cancer and 8 were in patients with pancreatic cancer. Cachexia or weight loss was associated with significantly poorer survival in patients with colorectal or pancreatic cancer in nearly two‐thirds of the studies. The classification of weight loss varied across and within studies (multiple categories were evaluated) and may have contributed to variability. Nonetheless, awareness of cachexia and routine assessment of weight change in clinical practice in patients with colorectal or pancreatic cancer could help inform prognosis and influence early disease management strategies.
Unusual late‐onset hypertrophic pyloric stenosis in an adolescent girl with down syndrome: Case report and review of the literature
Authors: Chiodi Annalisa , Escolino Maria , Di Mento Claudia , Salvati Vincenzo , Mazzone Valerio , Esposito Giorgia , Porcaro Mauro , Esposito Ciro 
Published: August 2024

AbstractA 16‐year‐old girl with down syndrome came to our attention for recurrent postprandial vomiting and significant weight loss (>5 kgs). Diagnostic assessment (barium swallow study, ultrasonography, and CT) confirmed hypertrophic pyloric stenosis (HPS). Initial attempt with endoscopic dilation was not successful. The patient underwent Heineke–Mikulicz pyloroplasty. Full oral feeding was achieved by Day 7 postoperatively. At 6‐month follow‐up, the patient reported relief of symptoms, normal feeding habits and substantial weight gain. HPS should be considered in the differential diagnosis of recurrent vomiting, regardless of age. A comprehensive diagnostic work‐up, including ultrasonography, endoscopy, and CT, is recommended to confirm the diagnosis.
Evaluating physiological barriers to oral intake in hospitalized patients: A secondary analysis
Authors: Viner Smith Elizabeth , Kouw Imre W. K. , Summers Matthew J. , Louis Rhea , Chapman Marianne J. , Chapple Lee‐anne S. 
Published: August 2024

AbstractBackgroundOral intake in hospitalized patients is frequently below estimated targets. Multiple physiological symptoms are proposed to impact oral intake, yet many have not been quantified objectively.AimTo describe the challenges of objectively measuring physiological nutrition‐impacting symptoms in hospitalized patients.MethodA secondary analysis of data from a single‐center, descriptive cohort study of physiological nutrition‐impacting symptoms in intensive care unit (ICU) survivors and general medical patients was conducted. Demographic and clinical characteristics were extracted for patients who completed the original study and collected retrospectively for those who were screened and recruited but did not complete the original study. Reasons for patient exclusion from the original study were quantified from the screening database. Descriptive data are reported as mean ± SD, median [interquartile range], or number (percentage).ResultsICU survivors and general medical patients were screened for inclusion in the original study between March 1 and December 23, 2021. Of the 644 patients screened, 97% did not complete the study, with 93% excluded at screening. Of the 266 ICU survivors and 398 general medical patients screened, 89% and 95% were excluded, respectively. Major exclusion criteria included the inability to follow commands or give informed consent (n = 155, 25%), the inability to consume the easy‐to‐chew and thin‐fluid buffet meal, and imminent discharge (both, n = 120, 19%).ConclusionUnderstanding physiological factors that drive reduced oral intake in hospitalized patients is challenging. Exclusion criteria required to objectively quantify physiological nutrition‐impacting symptoms significantly preclude participation and likely act as independent barriers to oral intake.
Travel market maven in a traditional marketplace
Authors: Taheri Babak , Olya Hossein , Kim Jinkyung Jenny 
Published: August 2024

AbstractMarket mavenism enhances the economic impacts of tourism. Using a convergent parallel mixed‐methods design, first, a quantitative study tests a conceptual model supported by goal‐setting theory to stimulate market mavenism in the traditional marketplace. Quantitative data are used to apply structural equation modeling and analysis of necessity to assess the sufficiency and necessity of market maven antecedents, respectively. The effect of nationality and travel types on the study variables are also investigated. Second, a qualitative study conducts interviews to explore mechanisms of market maven development through experience with the market in a traditional marketplace. Confusion proneness and choice confidence are sufficient and necessary predictors of market mavenism. Evaluation costs and final negative affect are sufficient but unnecessary to achieve market mavenism. Asian consumers receive a greater market maven experience compared to consumers from other regions.