bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preclinical evaluation of [18F]FP-CIT, the radiotracer targeting dopamine transporter for diagnosing Parkinson’s disease: pharmacokinetic and efficacy analysis
Authors: Ahn Jae Hun , Kim Min Hwan , Lee Kyongkyu , Oh Keumrok , Lim Hyunwoo , Kil Hee Seup , Kwon Soon Jeong , Choi Jae Yong , Chi Dae Yoon , Lee Yong Jin 
Published: July 2024

Abstract
Background
N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (FP-CIT), the representative cocaine derivative used in dopamine transporter imaging, is a promising biomarker, as it reflects the severity of Parkinson’s disease (PD). 123I- and 18F-labeled FP-CIT has been used for PD diagnosis. However, preclinical studies evaluating [18F]FP-CIT as a potential diagnostic biomarker are scarce. Among translational research advancements from bench to bedside, translating preclinical findings into clinical practice is one-directional. The aim of this study is to employ a circular approach, beginning back from the preclinical stage, progressing to the supplementation of [18F]FP-CIT, and subsequently returning to clinical application. We investigated the pharmacokinetic properties of [18F]FP-CIT and its efficacy for PD diagnosis using murine models.

Results
Biodistribution, metabolite and excretion analyses were performed in mice and PD models were induced in rats using 6-hydroxydopamine (6-OHDA). The targeting efficiency of [18F]FP-CIT for the dopamine receptor was assessed through animal PET/CT imaging. Subsequently, correlation analysis was conducted between animal PET/CT imaging results and immunohistochemistry (IHC) targeting tyrosine hydroxylase. Rapid circulation was confirmed after [18F]FP-CIT injection. [18F]FP-CIT reached the highest uptake of 23.50 ± 12.46%ID/g in the striatum 1 min after injection, and it was rapidly excreted within 60 min. The major metabolic organs of [18F]FP-CIT were confirmed to be the intestines, liver, and kidneys. Its uptake in the intestine was approximately 5% ID/g. The uptake in the liver gradually increased, with excretion beginning after reaching a maximum after 60 min. The kidneys exhibited rapid elimination after 10 min. In the excretion study, rapid elimination was verified, with 21.46 ± 9.53% of the compound excreted within a 6 h period. Additionally, the efficacy of [18F]FP-CIT PET was demonstrated in the PD model, with a high correlation with IHC for both the absolute value (R = 0.803, p = 0.0017) and the ratio value (R = 0.973, p = 0.0011).

Conclusions
This study fills the gap regarding insufficient preclinical studies on [18F]FP-CIT, including its ADME, metabolites, and efficiency. The pharmacological results, including accurate diagnosis, rapid circulation, and [18F]FP-CIT excretion, provide complementary evidence that [18F]FP-CIT can be used safely and efficiently to diagnose PD in clinics, although it is already used in clinics.
Upper gastrointestinal bleeding on veno-arterial extracorporeal membrane oxygenation support
Authors: de Roux Quentin , Disli Yekcan , Bougouin Wulfran , Renaudier Marie , Jendoubi Ali , Merle Jean-Claude , Delage Mathilde , Picard Lucile , Sayagh Faiza , Cherait Chamsedine , Folliguet Thierry , Quesnel Christophe , Becq Aymeric , Mongardon Nicolas 
Published: July 2024

Abstract
Introduction
Patients on veno-arterial extracorporeal membrane oxygenation (V-A ECMO) support are at a high risk of hemorrhagic complications, including upper gastrointestinal bleeding (UGIB). The objective of this study was to evaluate the incidence and impact of this complication in V-A ECMO patients.

Materials and methods
A retrospective single-center study (2013–2017) was conducted on V-A ECMO patients, excluding those who died within 24 h. All patients with suspected UGIB underwent esophagogastroduodenoscopy (EGD) and were analyzed and compared to the remainder of the cohort, from the initiation of ECMO until 5 days after explantation.

Results
A total of 150 V-A ECMO cases (65 after cardiac surgery and 85 due to medical etiology) were included. 90% of the patients received prophylactic proton pump inhibitor therapy and enteral nutrition. Thirty-one patients underwent EGD for suspected UGIB, with 16 confirmed cases of UGIB. The incidence was 10.7%, with a median occurrence at 10 [7–17] days. There were no significant differences in clinical or biological characteristics on the day of EGD. However, patients with UGIB had significant increases in packed red blood cells and fresh frozen plasma needs, mechanical ventilation duration and V-A ECMO duration, as well as in length of intensive care unit and hospital stays. There was no significant difference in mortality. The only independent risk factor of UGIB was a history of peptic ulcer (OR = 7.32; 95% CI [1.07–50.01], p = 0.042).

Conclusion
UGIB occurred in at least 1 out of 10 cases of V-A ECMO patients, with significant consequences on healthcare resources. Enteral nutrition and proton pump inhibitor prophylaxis did not appear to protect V-A ECMO patients. Further studies should assess their real benefits in these patients with high risk of hemorrhage.
On generalized $(k,\psi )$-Hilfer proportional fractional operator and its applications to the higher-order Cauchy problem
Authors: Sudsutad Weerawat , Kongson Jutarat , Thaiprayoon Chatthai 
Published: July 2024

AbstractIn this work, we introduce a novel idea of generalized $({{k}},\psi )$
(
k
,
ψ
)
-Hilfer proportional fractional operators. The proposed operator combines the $({{k}},\psi )$
(
k
,
ψ
)
-Riemann–Liouville and $({{k}},\psi )$
(
k
,
ψ
)
-Caputo proportional fractional operators. Some properties and auxiliary results of the proposed operators are investigated. The ψ-Laplace transform and its properties of the proposed operators are established and utilized to solve Cauchy-type problems. Furthermore, the uniqueness result for a higher-order initial value problem under $({{k}},\psi )$
(
k
,
ψ
)
-Hilfer proportional fractional operators is proved by using Picard’s iterative technique. At the end, examples are provided to present the theoretical results. This new type of proposed operator can help other researchers who are still working on real-world problems.
Structural Performance of Ferrocement Hollow Shear Walls Subjected to Lateral and Compressive Axial Loads
Authors: Shaheen Yousry B. , Eltaly Boshra A. , Khairy Samar , Fayed Sabry 
Published: July 2024

AbstractIn this study, ten shear walls were experimentally tested to examine behaviour of ferrocement hollow shear walls subjected to axial and lateral loads. Ferrocement mortar (FM) was used to build eight walls, while normal concrete (NC) was used to build two controls. Walls were lateral reinforced using conventional stirrups, two layers of welded wire mesh (WWM), and expanded steel mesh (ESM). Two specimens lacked lateral reinforcement except for one transverse web in the center of the inner hole. Two symmetric groups of five walls each were created by dividing the walls. While the other group was loaded laterally, one group was loaded axially. In each group, the load–displacement relationship, maximum load and associated displacement, stiffness, ductility, and failure mechanism of FM and NC walls were compared. The results showed that FM walls provided with ESM and WWM had ultimate axial loads that were, respectively, 36% and 19% higher than NC control walls. Ultimate lateral loads and related ultimate drifts of FM walls reinforced with two layers of WWM and ESM were, respectively, 68% and 39%, 96% and 43.5%, larger than control NC wall. For lateral loads greater than those applied to the NC control wall, stiffness increase ratios for FM walls ranged from 2.5% to 89.5%, and for axial loads, they ranged from 20% to 150.5%. The ductility of FM walls increased when compared to NC walls by 58.5% and 158.8% for axial and lateral loading, respectively, when two layers of WWM were utilized to lateral reinforce FM walls. When two layers of ESM were applied to laterally reinforce FM walls in comparison to an NC wall, this increased the walls' ductility under axial and lateral loads by 110.5% and 214.7%, respectively.
Corrosion mechanisms for lead-glazed pottery from Qibi Ming Tomb of the Tang Dynasty in Xianyang, China
Authors: Li Yanli , Liu Panpan , Luo Yujia , Ge Mantang , Xing Huiping , Li Yuhu 
Published: July 2024

Abstract
Six corroded glazed pottery figurines, which excavated from the Qibi Ming Tomb of the Tang Dynasty in Xianyang, were selected to study the corrosion mechanism. Optical microscopy (OM), scanning electron microscopy equipped with energy dispersive X-ray spectrometry (SEM–EDS), Energy X-ray fluorescence spectrometry (EDX), and micro-Raman spectroscopy were applied to analyze the pristine composition of the glaze layer and pottery substrate, the composition and microstructure of corrosion products. The results indicate that lead-glazed pottery figurines are low-temperature PbO-CaO-SiO2 glaze, with Pb as the main flux, and Cu, Fe as the main colorant. The corrosion products include PbCO3, CaCO3, PbCO3·PbCl2, PbCl2, PbO2, and Si-rich layer. There are Aspergillus niger and Aspergillus sclerotiorum on the surface of glazed pottery. These microorganisms produce organic acids and mold spots on the surface of the pottery figurines, which in turn cause corrosion pits to form on the surface of the figurines. Chemical corrosion reactions mainly include dissolution–precipitation, combination reaction, and oxidation reaction. This article describes the corrosion process of lead-glazed pottery figurines and establishes corresponding corrosion models. This study provides new insights into the corrosion mechanism of lead-glazed pottery, which is of great significance for studying pottery corrosion.
Cervical vertebral and spinal cord injuries in rollover occupants
Authors: Al-Salehi Loay , Kroeker Shannon G. , Kerrigan Jason R. , Cripton Peter A. , Panzer Matthew B. , Siegmund Gunter P. 
Published: July 2024

Abstract
Background
Rollover crashes continue to be a substantial public health issue in North America. Previous research has shown that the cervical spine is the most injured spine segment in rollovers, but much of the past research has focused on risk factors rather than the actual cervical spine injuries. We sought to examine how different types of cervical spine injuries (vertebral and/or cord injury) vary with different occupant-related factors in rollovers and to compare these with non-rollovers.

Methods
We obtained crash and injury information from the National Automotive Sampling System–Crashworthiness Data System (NASS-CDS) for 2005–2015 and Crash Investigation Sampling System (CISS) for 2017–2022. Based on weighted data, we calculated relative risks to assess how occupant sex, seat belt use, ejection status, and fatal outcome relate to the rate of different cervical spine injuries in rollovers and non-rollovers.

Results
In NASS-CDS occupants with cervical spine injuries (N = 111,040 weighted cases), about 91.5% experienced at least one vertebral injury whereas only 11.3% experienced a spinal cord injury (most of which had a concomitant vertebral fracture). All types of cervical spine injuries we examined were 3.4–5.2 times more likely to occur in rollovers compared to non-rollovers. These relative risks were similar for both sexes, belted and unbelted, non-ejected, and non-fatal occupants. The number of weighted CISS occupants with cervical spine injuries (N = 42,003) was smaller than in the NASS analysis, but cervical spine injuries remained 6.25 to 6.36 times more likely in rollovers compared to non-rollovers despite a more modern vehicle fleet.

Conclusions
These findings underscore the continued need for rollover-specific safety countermeasures, especially those focused on cervical spine injury prevention, and elucidate the frequency, severity and other characteristics of the specific vertebral and spinal cord injuries being sustained in rollovers. Our findings suggest that countermeasures focused on preventing cervical vertebral fractures will also effectively prevent most cervical spinal cord injuries.
Cognition trajectory in Duchenne muscular dystrophy
Authors: Tony Abeer A. , Abdelrashid Sara , Ahmed Hoda S. , Khodair Mohamed Rizk 
Published: July 2024

Abstract
Background
Duchenne muscular dystrophy (DMD) is an X-linked recessive disease brought on by genetic changes that alter the dystrophin (DYS) protein. There has been growing evidence that children with DMD have been at higher risk of developing symptoms of neurodevelopmental disorders. We aimed at defining the cognitive difficulties and their categories in patients with DMD, compared to healthy controls, and assessing their relation with the functional severity. This work was a multi-center, observational, case–control study conducted on DMD patients. Age and sex-matched healthy subjects with no neurologic, psychiatric, or medical comorbidities were included as normal controls.

Results
There was a statistically significant difference in cognitive patterns between the studied groups. We have observed a significant relationship between cognitive difficulties and functional severity assessment in our patients. There was a statistically significant difference between the studied cases regarding basic characteristics and correlation between cognitive functions and demographic data.

Conclusions
The decline in cognitive functions in DMD patients compared to healthy controls was established. Education was the most affected domain in patients, with more speech delay and dropping out of school. Therefore, it was recommended to establish cognitive screening as a routine in the evaluation and follow-up of DMD children.
Application of energy combined thermal comfort in intelligent building management in complex environments
Authors: Wang Xiaoyu 
Published: July 2024

AbstractThe efficient operation of heating ventilation and air conditioning systems relies on advanced control strategies. However, current control methods are often limited by issues such as uncertain system parameter information and spatial coupling constraints related to the supply rate of the air supply fan. To this end, an energy joint thermal comfort management method for complex environments in multiple regions is proposed. The long-term total cost minimization of the system is established, and then the Lyapunov optimization technology is used to design the distributed control algorithm. Simulation validation shows that the proposed method reduces the energy cost by an average of 11.24% compared to other methods with a thermal discomfort cost coefficient of 0. The average temperature deviation in the area is improved by 0.15 °C and 0.68 °C, respectively. The method saves more than 10% of the total energy cost under different thermal perturbations with an average total temperature deviation of 0.04 °C. The results indicate that the proposed energy joint thermal comfort management method can flexibly balance energy costs and user thermal comfort without knowing any prior information of system parameters, which can also greatly protect user privacy information. This method has application value in the control of heating ventilation and air conditioning systems in complex environments such as commercial buildings.
Understanding the epidemiology and perceived efficacy of cannabis use in patients with chronic musculoskeletal pain
Authors: Leroux Timothy , Ajrawat Prabjit , Sundararajan Kala , Maldonado-Rodriguez Naomi , Ravi Bheeshma , Gandhi Rajiv , Rampersaud Raja , Veillette Christian , Mahomed Nizar , Clarke Hance 
Published: July 2024

Abstract
Background
The belief that cannabis has analgesic and anti-inflammatory properties continues to attract patients with chronic musculoskeletal (MSK) pain towards its use. However, the role that cannabis will play in the management of chronic MSK pain remains to be determined. This study examined 1) the rate, patterns of use, and self-reported efficacy of cannabis use among patients with chronic MSK pain and 2) the interest and potential barriers to cannabis use among patients with chronic MSK pain not currently using cannabis.

Methods
Self-reported cannabis use and perceived efficacy were prospectively collected from chronic MSK pain patients presenting to the Orthopaedic Clinic at the University Health Network, Toronto, Canada. The primary dependent variable was current or past use of cannabis to manage chronic MSK pain; bivariate and multivariable logistic regression were used to identify patient characteristics independently associated with this outcome. Secondary outcomes were summarized descriptively, including self-perceived efficacy among cannabis users, and interest as well as barriers to cannabis use among cannabis non-users.

Results
The sample included 629 patients presenting with chronic MSK pain (mean age: 56±15.7 years; 56% female). Overall, 144 (23%) reported past or present cannabis use to manage their MSK pain, with 63.7% perceiving cannabis as very or somewhat effective and 26.6% considering it as slightly effective. The strongest predictor of cannabis use in this study population was a history of recreational cannabis use (OR 12.7, p<0.001). Among cannabis non-users (N=489), 65% expressed interest in using cannabis to manage their chronic MSK pain, but common barriers to use included lack of knowledge regarding access, use and evidence, and stigma.

Conclusions
One in five patients presenting to an orthopaedic surgeon with chronic MSK pain are using or have used cannabis with the specific intent to manage their pain, and most report it to be effective. Among non-users, two-thirds reported an interest in using cannabis to manage their MSK pain, but common barriers to use existed. Future double-blind placebo-controlled trials are required to understand if this reported efficacy is accurate, and what role, if any, cannabis may play in the management of chronic MSK pain.
A privacy-preserving image retrieval scheme with access control based on searchable encryption in media cloud
Authors: Tian Miao , Zhang Yushu , Zhang Yongming , Xiao Xiangli , Wen Wenying 
Published: July 2024

AbstractWith the popularity of the media cloud computing industry, individuals and organizations outsource image computation and storage to the media cloud server to reduce the storage burden. Media images usually contain a large amount of private information. To prevent disclosure of privacy of the image owners, media images are encrypted before uploading to the server. However, this operation will greatly limit the utilization of the image for the user, such as content-based image retrieval. We propose an efficient similarity query algorithm with access control based on Bkd-tree in this paper, in which a searchable encryption scheme is designed for similarity image retrieval, and the encrypted image is used to extract image features by a pre-trained CNN model. The Bkd-tree is utilized to generate an index tree for the image features to speed up retrieval and make it faster than linear indexing. Finally, the security performances of the proposed scheme is analyzed and the performance of this scheme is evaluated by experiments. The results show that the security of the image content and image features can be ensured, and it has a shorter retrieval time and higher retrieval efficiency.
Characterization of the fungal genus Sphaerellopsis associated with rust fungi: species diversity, host-specificity, biogeography, and in-vitro mycoparasitic events of S. macroconidialis on the southern corn rust, Puccinia polysora
Authors: Gómez-Zapata Paula Andrea , Díaz-Valderrama Jorge Ronny , Fatemi Samira , Ruiz-Castro Cristhian Orlando , Aime M. Catherine 
Published: July 2024

AbstractSphaerellopsis species are putative hyperparasites of rust fungi and may be promising biological control agents (BCA) of rust diseases. However, few detailed studies limit potential BCA development in Sphaerellopsis. Here, we explored the biogeography, host-specificity, and species diversity of Sphaerellopsis and examined the early infection stage of one species, S. macroconidialis, to infer its trophic status. We randomly screened 5,621 rust specimens spanning 99 genera at the Arthur Fungarium for the presence of Sphaerellopsis. We identified 199 rust specimens infected with Sphaerellopsis species on which we conducted morphological and multi-locus phylogenetic analyses. Five Sphaerellopsis species were recovered, infecting a total of 122 rust species in 18 genera from 34 countries. Sphaerellopsis melampsorinearum sp. nov. is described as a new species based on molecular phylogenetic data and morphological features of the sexual and asexual morphs. Sphaerellopsis paraphysata was the most commonly encountered species, found on 77 rust specimens, followed by Sphaerellopsis macroconidialis on 56 and S. melampsorinearum on 55 examined specimens. The type species, Sphaerellopsis filum, was found on 12 rust specimens and Sphaerellopsis hakeae on a single specimen. We also recovered and documented for the first time, the sexual morph of S. macroconidialis, from a specimen collected in Brazil. Our data indicate that Sphaerellopsis species are not host specific and furthermore that most species are cosmopolitan in distribution. However, S. paraphysata is more abundant in the tropics, and S. hakeae may be restricted to Australia. Finally, we confirm the mycoparasitic strategy of S. macroconidialis through in-vitro interaction tests with the urediniospores of Puccinia polysora. Shortly after germination, hyphae of S. macroconidialis began growing along the germ tubes of P. polysora and coiling around them. After 12 days of co-cultivation, turgor loss was evident in the germ tubes of P. polysora, and appressorium-like structures had formed on urediniospores. The interaction studies indicate that Sphaerellopsis species may be more effective as a BCA during the initial stages of rust establishment.
The effect of transferring a low-quality embryo along with a high-quality embryo on the pregnancy outcome
Authors: Huang Xianju , Lu Xinle , Jiang Xue , Chao Ludan , Wang Xiao 
Published: July 2024

Abstract
Background
Previous evidence suggests that low-quality embryos may send negative signals to the endometrium and affect the receptivity of the endometrium. This study aimed to evaluate the influence of transferring an additional low-quality embryo with a high-quality embryo on the pregnancy outcome.

Methods
A total of 1506 fresh embryo transfer cycles between January 2018 and June 2020 were included. The patients were separated into two groups: a single embryo transfer group (SET, patients receiving a single high-quality embryo) and a double embryo transfer group (DET, patients receiving a high-quality embryo and a low-quality embryo). Main outcome measures including multiple pregnancy rate and live birth rate were discussed.
Overall, in the primary analysis, patients who receive an additional low-quality embryo improved the live birth by 8.7% and multiple pregnancy rate by 10.0%. In women aged less than 35 years, compared with SET, DET increased the birth rate by 6.0% but resulted in a 13.5% increase in multiples. Women of 35 years above, adding a low-quality embryo increased the live birth rate by only 2.2% but increased multiples by 14.7%. In patients with one cycle of ET, the same results were obtained. In patients with multiple cycles of ET and adding a low-quality embryo, the live birth rate was similar to SET but with a 14.7% increase in multiples.

Conclusions
Compared to DET, we prefer to transfer a high-quality embryo. Nevertheless, in women 35 years or older or in patients with multiple cycles of embryo transfer, adding a low-quality embryo did not significantly improve live birth but increased the multiple rate.