bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurologic Disorders Among Pediatric Deaths Associated With the 2009 Pandemic Influenza
Authors: Blanton Lenee , Peacock Georgina , Cox Chad , Jhung Michael , Finelli Lyn , Moore Cynthia 
Published: August 2012

OBJECTIVE:The goal of this study was to describe reported influenza A (H1N1)pdm09 virus (pH1N1)-associated deaths in children with underlying neurologic disorders.METHODS:The study compared demographic characteristics, clinical course, and location of death of pH1N1-associated deaths among children with and without underlying neurologic disorders reported to the Centers for Disease Control and Prevention.RESULTS:Of 336 pH1N1-associated pediatric deaths with information on underlying conditions, 227 (68%) children had at least 1 underlying condition that conferred an increased risk of complications of influenza. Neurologic disorders were most frequently reported (146 of 227 [64%]), and, of those disorders, neurodevelopmental disorders such as cerebral palsy and intellectual disability were most common. Children with neurologic disorders were older (P = .02), had a significantly longer duration of illness from onset to death (P &lt; .01), and were more likely to die in the hospital versus at home or in the emergency department (P &lt; .01) compared with children without underlying medical conditions. Many children with neurologic disorders had additional risk factors for influenza-related complications, especially pulmonary disorders (48%). Children without underlying conditions were significantly more likely to have a positive result from a sterile-site bacterial culture than were those with an underlying neurologic disorder (P &lt; .01).CONCLUSIONS:Neurologic disorders were reported in nearly two-thirds of pH1N1-associated pediatric deaths with an underlying medical condition. Because of the potential for severe outcomes, children with underlying neurologic disorders should receive influenza vaccine and be treated early and aggressively if they develop influenza-like illness.
Cancer Patient Disclosure and Patient-Doctor Communication of Complementary and Alternative Medicine Use: A Systematic Review
Authors: Davis Esther L. , Oh Byeongsang , Butow Phyllis N. , Mullan Barbara A. , Clarke Stephen 
Published: August 2012

AbstractLearning ObjectivesAfter completing this course, the reader will be able to: Discuss the danger inherent in nondisclosure of complementary and alternative medicine (CAM) use due to the potential for herb- or vitamin-drug interactions with conventional treatment.Explain the need for greater patient-doctor communication about CAM use in oncology settings in order to maintain patient safety and wellbeing.CME This article is available for continuing medical education credit at CME.TheOncologist.comObjective.To explore the nondisclosure of complementary and alternative medicine (CAM) use among cancer patients, including reasons for and outcomes from nondisclosure of CAM use, within the context of patient-doctor communication.Method.A systematic review was conducted exploring investigations surrounding the communication of CAM use for patients with cancer published until August 2011.Results.A total of 21 studies were located, which reported a prevalence of CAM use among patients with cancer ranging between 11% and 95%; of these patients, 20% to 77% did not disclose their CAM use. The main reasons for nondisclosure were the doctor's lack of inquiry; patient's anticipation of the doctor's disapproval, disinterest, or inability to help; and patient's perception that disclosure of CAM use is irrelevant to their conventional care. There is some evidence to suggest that patient-doctor communication about the use of CAM was associated with an enhanced patient-doctor relationship and higher patient satisfaction.Conclusions.Although the use of CAM by patients with cancer is high, patients frequently fail to disclose its use to their health professionals for reasons emanating from both sides of the dyadic patient-doctor relationship. Because a substantial proportion of patients with cancer may use CAM and there is potential for herb- or vitamin-drug interactions, further research in patient-doctor communication about CAM is necessary to maintain patient safety and wellbeing. The development of effective interventions to improve the disclosure of CAM use should be an integral part of this future research.
Matrix Metalloproteinases, Tissue Inhibitors of Matrix Metalloproteinases, and Inflammation in Cyclosporine A–Induced Gingival Enlargement: A Pilot In Vitro Study Using a Three‐Dimensional Model of the Human Oral Mucosa
Authors: Johanson Matthew , Zhao Xiang R. , Huynh‐Ba Guy , Villar Cristina C. 
Published: August 2012

Background: It has been suggested that cyclosporine A (CsA) induces gingival enlargement by promoting an increase in the gingival extracellular matrix (ECM). Nonetheless, the variable occurrence of CsA‐induced gingival enlargement in patients receiving this medication indicates a multifactorial pathogenesis. Clinical observations suggest that local inflammation is associated with the development and severity of CsA‐induced gingival enlargement. Therefore, the purpose of this study is to investigate the effects of CsA and inflammation on the production of ECM homeostatic mediators.Methods: The effects of CsA and inflammation (as assessed using interleukin [IL]‐1β) on the secretion of mediators involved in ECM homeostasis were determined using fibroblast monolayers and three‐dimensional (3D) models of the human oral mucosa. Fibroblast monolayers and 3D cultures were treated with CsA alone or in combination with IL‐1β for up to 72 hours, and the secretion of matrix metalloproteinases (MMPs) 1, 2, 3, 8, 9, 10, and 13 and tissue inhibitors of MMPs (TIMPs) 1, 2, and 4 into the culture medium was assessed using enzyme‐linked immunoassay–based antibody arrays.Results: Fibroblast monolayers responded to CsA with no changes in the secretion of ECM mediators. Conversely, 3D cultures responded to CsA treatment with a reduction in MMP‐10 secretion. IL‐1β alone triggered higher secretory levels of MMPs in both fibroblast monolayers (MMP‐3 and MMP‐10) and 3D cultures (MMP‐9 and MMP‐10). Importantly, fibroblast monolayers and 3D cultures treated with a combination of IL‐1β and CsA showed a decrease in the MMP‐1/TIMP‐1 ratio.Conclusions: These data support the hypothesis that inflammation may alter the pathogenesis of CsA‐induced gingival enlargement by promoting a synergistic decrease in the MMP‐1/TIMP‐1 ratio.
The Moderating Effects of the Incentive System and Performance Measure on Managers' and Their Superiors' Expectations about the Manager's Effort
Authors: Cianci Anna M. , Kaplan Steven E. , Samuels Janet A. 
Published: August 2012

ABSTRACT:
The current study experimentally examines effort expectations (i.e., planned hours) for a manager made by participants in the role of the manager or the manager's superior. The experiment also manipulates the type of incentive system (i.e., bonus based on either strategic or all measures) and the type of performance measure (i.e., strategic or general). We predict and find that the participants in the manager role engage in self-enhancement (e.g., Pfeffer and Fong 2005; Sedikides and Gregg 2008). Specifically, the total hours that managers planned to work were more than the total hours their superiors expected the manager to work. We also find that both the type of incentive system and the type of performance measure moderate managers' tendency to engage in self-enhancement. Compared to a strategic incentive system, managers' self-enhancement was diminished under a comprehensive incentive system. Further, participants in the manager role engage in self-enhancement for planned strategic hours but not for planned general hours.
Data Availability: Available upon request.
Metabolic Syndrome Model Definitions Predicting Type 2 Diabetes and Cardiovascular Disease
Authors: Povel Cécile M. , Beulens Joline W. , van der Schouw Yvonne T. , Dollé Martijn E.T. , Spijkerman Annemieke M.W. , Verschuren W.M. Monique , Feskens Edith J.M. , Boer Jolanda M.A. 
Published: August 2012

OBJECTIVE
Metabolic syndrome (MetS) is a cluster of abdominal obesity, hyperglycemia, hypertension, and dyslipidemia, which increases the risk for type 2 diabetes and cardiovascular diseases (CVDs). Some argue that MetS is not a single disorder because the traditional MetS features do not represent one entity, and they would like to exclude features from MetS. Others would like to add additional features in order to increase predictive ability of MetS. The aim of this study was to identify a MetS model that optimally predicts type 2 diabetes and CVD while still representing a single entity.

RESEARCH DESIGN AND METHODS
In a random sample (n = 1,928) of the EPIC-NL cohort and a subset of the EPIC-NL MORGEN study (n = 1,333), we tested the model fit of several one-factor MetS models using confirmatory factor analysis. We compared predictive ability for type 2 diabetes and CVD of these models within the EPIC-NL case-cohort study of 545 incident type 2 diabetic subjects, 1,312 incident CVD case subjects, and the random sample, using survival analyses and reclassification.

RESULTS
The standard model, representing the current MetS definition (EPIC-NL comparative fit index [CFI] = 0.95; MORGEN CFI = 0.98); the standard model excluding blood pressure (EPIC-NL CFI = 0.95; MORGEN CFI = 1.00); and the standard model extended with hsCRP (EPIC-NL CFI = 0.95) had an acceptable model fit. The model extended with hsCRP predicted type 2 diabetes (integral discrimination index [IDI]: 0.34) and CVD (IDI: 0.07) slightly better than did the standard model.

CONCLUSIONS
It seems valid to represent the traditional MetS features by a single entity. Extension of this entity with hsCRP slightly improves predictive ability for type 2 diabetes and CVD.
Novel Risk Factors and the Prediction of Type 2 Diabetes in the Atherosclerosis Risk in Communities (ARIC) Study
Authors: Raynor L.A. , Pankow James S. , Duncan Bruce B. , Schmidt Maria I. , Hoogeveen Ron C. , Pereira Mark A. , Young J. Hunter , Ballantyne Christie M. 
Published: August 2012

OBJECTIVE
The objective of this study was to determine potential added value of novel risk factors in predicting the development of type 2 diabetes beyond that provided by standard clinical risk factors.

RESEARCH DESIGN AND METHODS
The Atherosclerosis Risk in Communities (ARIC) Study is a population-based prospective cohort study in four U.S. communities. Novel risk factors were either measured in the full cohort or in a case-control sample nested within the cohort. We started with a basic prediction model, previously validated in ARIC, and evaluated 35 novel risk factors by adding them independently to the basic model. The area under the curve (AUC), net reclassification index (NRI), and integrated discrimination index (IDI) were calculated to determine if each of the novel risk factors improved risk prediction.

RESULTS
There were 1,457 incident cases of diabetes with a mean of &gt;7.6 years of follow-up among 12,277 participants at risk. None of the novel risk factors significantly improved the AUC. Forced expiratory volume in 1 s was the only novel risk factor that resulted in a significant NRI (0.54%; 95% CI: 0.33–0.86%). Adiponectin, leptin, γ-glutamyl transferase, ferritin, intercellular adhesion molecule 1, complement C3, white blood cell count, albumin, activated partial thromboplastin time, factor VIII, magnesium, hip circumference, heart rate, and a genetic risk score each significantly improved the IDI, but net changes were small.

CONCLUSIONS
Evaluation of a large panel of novel risk factors for type 2 diabetes indicated only small improvements in risk prediction, which are unlikely to meaningfully alter clinical risk reclassification or discrimination strategies.
LC-MS and FT-IR characterization of amber artifacts
Authors: Truică Georgiana , Teodor Eugenia , Litescu Simona , Radu Gabriel 
Published: August 2012

Abstract
This work focuses on using analytical methods, such as Fourier transform Infrared spectroscopy (FTIR) and high performance liquid chromatography (HPLC) with mass spectrometry (MS) detection to assess archaeological and geological amber. The main goal of this study is to apply the previously developed and optimized analytical methods in verifying criteria to ascribe and characterize the origin of materials found in archaeological sites. The proposed LC-MS method was successfully applied for the quantification of succinic acid content both in geological and archaeological samples of amber and offers excellent linearity between 0.1 and 5µg mL−1. The developed FTIR method provided some criteria which is able to differentiate between Baltic and Romanian amber (Romanite) that furthermore validates on archaeological amber artefacts.
Application of UV detection in HPLC in the total antioxidant potential assay
Authors: Wantusiak Paweł , Głód Bronisław 
Published: August 2012

Abstract
HPLC has been already used for the TAP estimation. Phenylalanine, salicylic, p-hydroxybenzoic (pHBA) or terephthalic (TPA) acids have been used as sensor compounds. Products of their reaction with the hydroxyl radicals, generated in the Fenton-like reaction, were analyzed using electrochemical or fluorescence detection. This paper describes the TAP assay based on the hydroxyl radicals reaction with pHBA, reversed-phase-HPLC separation and UV photometric detection. The elaborated assay has been used to evaluate TAP values of some apiculture products.
A new method of proof of Filippov’s theorem based on the viability theorem
Authors: Plaskacz Sławomir , Wiśniewska Magdalena 
Published: August 2012

Abstract
Filippov’s theorem implies that, given an absolutely continuous function y: [t
0; T] → ℝd and a set-valued map F(t, x) measurable in t and l(t)-Lipschitz in x, for any initial condition x
0, there exists a solution x(·) to the differential inclusion x′(t) ∈ F(t, x(t)) starting from x
0 at the time t
0 and satisfying the estimation $$\left| {x(t) - y(t)} \right| \leqslant r(t) = \left| {x_0 - y(t_0 )} \right|e^{\int_{t_0 }^t {l(s)ds} } + \int_{t_0 }^t \gamma (s)e^{\int_s^t {l(\tau )d\tau } } ds,$$ where the function γ(·) is the estimation of dist(y′(t), F(t, y(t))) ≤ γ(t). Setting P(t) = {x ∈ ℝn: |x −y(t)| ≤ r(t)}, we may formulate the conclusion in Filippov’s theorem as x(t) ∈ P(t). We calculate the contingent derivative DP(t, x)(1) and verify the tangential condition F(t, x) ∩ DP(t, x)(1) ≠ ø. It allows to obtain Filippov’s theorem from a viability result for tubes.
Characterization of novel microsatellite markers for Eschscholzia californica (Papaveraceae), an invasive species in central Chile
Authors: Véliz David , Gauci Rachel , Bustamante Ramiro O. 
Published: August 2012

• Premise of the study: We isolated and characterized microsatellite markers for the California poppy, Eschscholzia californica, which is an invasive species in central Chile.• Methods and Results: A total of eight polymorphic and six monomorphic loci were developed for the species. Between one and 12 alleles were observed per locus. Polymorphic loci showed heterozygosity ranging from 0 to 0.875 in a sample of 96 individuals obtained from four populations. Only one locus showed significant departures from Hardy–Weinberg equilibrium at all sites.• Conclusions: The successful microsatellite amplification makes this set of primers an important tool for understanding the recent and future patterns of invasion and adaptation of E. californica into the new Chilean geographic area. The variation detected is currently being used in a more inclusive study that assesses population expansion in central Chile.
1974. About Anti-Oedipus
Authors: David-Ménard Monique 
Published: August 2012

La publication, en 1972, de L’Anti-Œdipe. Capitalisme et schizophrénie, par Gilles Deleuze et Félix Guattari, marque l’éloignement sans explication entre les psychanalystes et les philosophes critiques du « complexe d’Œdipe », considéré comme un mythe forgé par Freud. En lisant trois prises de position sur « l’Œdipe », qui ont suivi cette publication – celles de Jacques Lacan, de Michel Foucault et de Wladimir Granoff –, il s’agit d’évaluer pour aujourd’hui l’intérêt de ce débat manqué il y a quarante ans.
Asexuality, contemporary phenomenon?
Authors: Pardo Éléonore 
Published: August 2012

Les asexuels sont des hommes et des femmes qui disent n’avoir jamais éprouvé de désir sexuel envers quiconque. Ce ne sont pas pour autant des asexués, ils ne sont pas sans sexe. Ils expriment clairement l’idée de n’avoir aucun problème avec le sexe. Ils ont toujours existé, mais depuis les années 2000, via internet, ils souhaitent être reconnus comme tels. C’est à ce titre qu’ils nous interrogent. Comment dans le monde post-moderne s’articulent le corps et l’identité ? Les asexuels constituent-ils une nouvelle entité psychique ?
The bodily event, jouissance and the (post)modern subject
Authors: Canellopoulos Lissy 
Published: August 2012

Le symptôme en tant qu’événement de corps est le point d’exception du lien social établi et est impliqué dans la jouissance du corps. Le sujet de la modernité est soumis au lien social du discours capitaliste. Sa structure n’a pas changé, néanmoins sa relation avec le langage et la jouissance est modifiée. Le sujet invente des solutions pour fabriquer sa subjectivité et supporter son existence, mais aussi pour s’opposer à l’Autre ou pour signifier son annulation comme celle-ci est dictée par le discours capitaliste. Quelle est la place de la psychanalyse dans ces conditions d’avènement du sujet ?
La fabrique du corps sexué
Authors: Laufer Laurie 
Published: August 2012

En quoi la question de la sexualité est-elle importante dans la construction identitaire ? En quoi l’image du corps peut-elle déterminer la construction d’une identité sexuelle ? La fabrique d’un corps échappe-t-elle aux représentations de son temps ? Depuis le XVIIe siècle, la sexualité et les pratiques sexuelles sont l’objet et l’enjeu d’un discours scientifique qui détermine l’identité d’un sujet. Dans ses travaux, Michel Foucault étudie le discours sur le sexe qui établit historiquement le lien entre la sexualité, la subjectivité et l’obligation de vérité, une triade qu’il verse au compte de la psychanalyse comme héritière de cette scientia sexualis qui cherche la vérité au fond du sexe. La psychanalyse a-t-elle perdu le tranchant subversif de son geste qui invente la sexualité infantile polymorphe ?
L'expérience queer et l'inquiétant
Authors: Bourseul Vincent 
Published: August 2012

L’insulte queer désigne celui ou celle dont l’identité sexuelle est vécue comme étrange par un autre. L’étrangeté rencontrée favorise le surgissement de l’inquiétant et de l’angoisse liée. Ainsi « l’expérience queer » peut se lire avec l’inquiétant développé par Sigmund Freud comme le signe du retour d’un conflit psychique anciennement traité, dont le renouvellement dans le présent fait vaciller les solutions, les traitements, les théories infantiles, institués pour défendre le moi contre un conflit historique, par exemple celui lié à la différence sexuelle.
L'asexualité, phénomène contemporain ?
Authors: Pardo Éléonore 
Published: August 2012

Les asexuels sont des hommes et des femmes qui disent n’avoir jamais éprouvé de désir sexuel envers quiconque. Ce ne sont pas pour autant des asexués, ils ne sont pas sans sexe. Ils expriment clairement l’idée de n’avoir aucun problème avec le sexe. Ils ont toujours existé, mais depuis les années 2000, via Internet, ils souhaitent être reconnus comme tels. C’est à ce titre qu’ils nous interrogent. Comment dans le monde post-moderne s’articulent le corps et l’identité ? Les asexuels constituent-ils une nouvelle entité psychique ?
Questions sur la simulation
Authors: Lippi Silvia 
Published: August 2012

La jouissance féminine est considérée, par Lacan, en tant que « Autre » par rapport à celle de l’homme. Elle est, de toute façon, difficile à cerner, d’autant plus qu’elle peut être, comme le montre la clinique, facilement simulée par une femme. Mais pourquoi une femme se met-elle dans la position de simuler l’orgasme ? Quels sont, pour elle, les enjeux de cette pratique ? Nous essayerons de montrer que la simulation n’est pas seulement synonyme de frigidité. Elle peut l’être, bien sûr, mais elle est aussi source de plaisir pour une femme et, paradoxalement, un expédient capable de favoriser la « rencontre » avec l’autre.
Droit naturel et « hétéronormativité » en psychanalyse et dans les sciences sociales : une critique polémique
Authors: Pechriggl Alice 
Published: August 2012

Le présent texte est une critique des supposés naturalistes du droit qu’on peut trouver dans les discours anthropologiques et psychanalytiques et de leurs implications homophobes. Ceci s’est manifesté notamment lors des processus de législation concernant les couples gays et lesbiens. De l’autre côté il faut aussi voir les enracinements d’un concept vague et passe-partout d’hétéronormativité dans cette même tradition « jusnaturaliste ». Enfin il s’agira de montrer en quoi la psychanalyse de groupe, par la triangulation liée au groupe thérapeutique, pourrait contribuer à rompre les supposés, voire les dogmes essentialistes et discriminants concernant la sexualité que diffusent les institutions classiques de psychanalyse.
Sexualité et défiguration : des théories médicales du XIXe aux théories sexuelles infantiles de la psychanalyse
Authors: Linhares Andréa 
Published: August 2012

La littérature médicale du début du XIXe siècle établissait de façon récurrente un lien entre anatomie et préférences sexuelles. Selon nombre de médecins de cette époque, l’idée de la défiguration corporelle était articulée à des pratiques sexuelles déviantes. Elle était tantôt envisagée comme la cause des désirs interdits, tantôt comme la conséquence physique visible des rapports sexuels illicites. Ces conceptions historiques du corps et du sexe peuvent-elles apporter un éclairage sur certaines expériences recueillies dans la clinique analytique ? Tel est le pari de cet article. En effet, dès lors qu’elles se réfèrent aux désirs refoulés, du moins socialement, ces théorisations anatomo-pathologiques peuvent fonctionner comme un terrain privilégié pour le déploiement des fantasmes inconscients. Chez les médecins du XIXe siècle, l’idée de la défiguration venait rendre visibles les traces des pratiques sexuelles qui devaient rester invisibles en société (masturbation, pédérastie et saphisme). De la même manière, certaines situations cliniques laisseraient penser que le fantasme de défiguration vient donner une forme corporelle à des positions psychiques angoissantes, de par leur contenu sexuel refoulé. Comme si, afin d’être circonscrits et contenus, l’excès et le désordre pulsionnels du retour du refoulé appelaient la construction psychique d’une figure du corps.
Événement de corps, jouissance et sujet de la (post)modernité
Authors: Canellopoulos Lissy 
Published: August 2012

Le symptôme en tant qu’événement de corps est le point d’exception du lien social établi et est impliqué dans la jouissance du corps. Le sujet de la modernité est soumis au lien social du discours capitaliste. Sa structure n’a pas changé, néanmoins sa relation avec le langage et la jouissance est modifiée. Le sujet invente des solutions pour fabriquer sa subjectivité et supporter son existence, mais aussi pour s’opposer à l’Autre ou pour signifier son annulation comme celle-ci est dictée par le discours capitaliste. Quelle est la place de la psychanalyse dans ces conditions d’avènement du sujet ?