bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Therapeutic Potential of Ganoderma lucidum Karst and Ziziphus jujuba Mill for Postsurgical Adhesion Band Formation
Authors: Khalili-Tanha Ghazaleh , Nazari Seyedeh Elnaz , Asgharzadeh Fereshteh , Mobasheri Leila , Babaei Maryam , Naimi Hamideh , Maftooh Mina , Hassanian Seyed Mahdi , Eskandari Moein , Askarnia-Faal Mohammad Mostafa , Alaei Maryam , Ghorbani Hamid Reza , Aliakbarian Mohsen , Ferns Gordon , Khazaei Majid , Avan Amir 
Published: August 2024

Background:
Intra-abdominal adhesions are a commonly occurring postoperative complication
following abdominopelvic surgery. Peritoneal adhesion formation can lead to infertility,
chronic pelvic pain, and intestinal obstruction. The anti-inflammatory and anti-oxidant activities of
Ganoderma lucidum Karst (G. lucidum) and Ziziphus jujuba Mill (Z. jujuba) have been reported.
Here, we have explored the therapeutic potential of Ganoderma lucidum Karst (G. lucidum) and Z.
jujuba against postsurgical adhesion band formation. The NC3Rs ARRIVE guidelines were followed
during experimental studies.

Methods:
G. lucidum powder (800 mg/kg) and Z. jujuba powder (400 mg/kg) were administered
using oral gavage to different groups of male albino Wistar rats. After ten days of treatment, macroscopic
evidence for peritoneal adhesions and adhesion band score were determined. Furthermore, the
anti-inflammatory and antifibrosis effects of G. lucidum and Z. jujuba were assessed using histopathology,
ELISA, and real-time polymerase chain reaction methods. Also, alterations in some oxidative
stress parameters were evaluated.

Results:
G. lucidum and Z. jujuba significantly decreased adhesion bands and were associated with a
reduction in inflammatory cell infiltration into damaged tissues and the mRNA and protein expression
of inflammatory cytokines via modulation of TNF-α, IL-6, IL-1β, and TGF-β. Moreover, both
agents inhibited fibrotic adhesion band formation by decreasing collagen deposition and reducing
profibrotic marker expression, Col1A1, at the peritoneum adhesion tissues. G. lucidum and Z. jujuba
improved some antioxidant factors in rats’ adhesion tissues. The result of LC-MS showed that
Ganoderma lucidum Karst and Ziziphus jujuba Mill consist of components with antioxidant activity,
including ganoderic acid, lucidenic acid, quercetin, linoleic acid, malic acid, and benzoic acid.

Conclusion:
The results have demonstrated the therapeutic potential of G. lucidum and Z. jujuba in
reducing peritoneal adhesion through anti-inflammatory and anti-fibrotic properties, indicating their
promising value as a new therapeutic approach in preventing postsurgical adhesion.
New Approach as Inhibitor Against Head-Neck Cancer by In silico, DFT, FMOs, Docking, Molecular Dynamic, and ADMET of Euphorbia tirucalli (Pencil Cactus)
Authors: Al Mashud Md. Abdullah , Devnath Ramprosad , Anzuman Masuma , Sumona Mahbuba Iasmin , Hossain Md. Shamim , Kumer Ajoy , Talukder Md. Enamul Kabir , Rahman Md. Mashiar , Imon Raihan Rahman , Akash Shopnil , El Moussaoui Abdelfattah , Salamatullah Ahmad Mohammad , Bourhia Mohammed 
Published: August 2024

Background:
Head and neck cancer (HNC) is on the rise worldwide, endangering lives and straining
healthcare systems in both developing and developed nations. Despite the availability of a number of therapy
options, the success rate for treating and controlling head and neck cancer remains dismal. To combat the aggressiveness
and drug resistance of Epstein-Barr virus (EBV)-positive Head-Neck cancer cells, this study looks
into the potential of Euphorbia tirucalli (pencil cactus) leaf extract.

Objectives:
The goal of this study is to identify prospective therapeutic candidates from the extract of Euphorbia
tirucalli (pencil cactus) leaves, which have the ability to inhibit Epstein-Barr virus (EBV)-positive Head-
Neck cancer cells.

Materials and Methods:
The thirteen most important chemical components found in Euphorbia tirucalli (pencil
cactus) leaves were analyzed by means of molecular modeling techniques such as Absorption, Distribution,
Metabolism, Excretion, and Toxicity (ADMET), Quantum Mechanics (QM) calculation, molecular docking,
and molecular dynamics (MD) simulations. Using the Prediction of Activity Spectra for Substances (PASS)
model, we assess the potency of these compounds. Important molecular properties such as chemical potential,
electronegativity, hardness, and softness can be determined with the use of quantum chemical calculations employing
HOMO-LUMO analysis. These drugs' safety and toxicological characteristics are better understood to
assessments of their pharmacokinetics and ADMET. Finally, molecular dynamics simulations are employed to
verify binding interactions and assess the stability of docked complexes.

Results:
The molecular docking analysis identifies ligands (01), (02), and (10) as strong competitors, with
strong binding affinity for the Epstein-Barr virus (EBV)-positive Head-Neck cancer cell line. Not only do the
ligands (01), (02), and (10) match the criteria for a potential new inhibitor of head-neck cancer, but they also
outperform the present FDA-approved treatment.

Conclusion:
Taraxerol, euphol, and ephorginol, three phytochemicals isolated from the leaves of the Euphorbia
tirucalli (pencil cactus), have been identified as effective anti-cancer agents with the potential to serve as a foundation
for novel head-neck cancer therapies, particularly those targeting the Epstein-Barr virus (EBV)-overexpressing
subtype of this disease. An effective, individualized treatment plan for head-neck cancer is a long way off, but this
study is a major step forward that could change the lives of patients and reduce the global burden of this disease.
The Role of Mycorrhizal Fungi in Orchids
Authors: Kaur Saranjeet , Deb Akash 
Published: August 2024

Background:
In nature, orchid plants are obligate myco-heterotrophs, and rely
on mycorrhizal nutrient resources to grow and sustain in the wild, until they become
physiologically active photosynthetic plants. Their seeds lack nutrient reserves and receive
the necessary carbon from symbiotic fungi during germination. A mycorrhizal fungus
provides nutrients, especially sugars, as well as water to the corresponding host plant.
The range and distribution of orchid mycorrhizal fungi influence the survivability of orchid
populations in their natural habitats. Mycorrhizae form symbiotic connections with
the parenchymatous tissues of the roots of orchid plants. That the symbiotic orchid
mycorrhiza can invade through roots of orchid seedling, raised in vitro, has been patented.

Objective:
The objective of this study was to examine the presence of mycorrhiza in the
roots of Aerides multiflora during the vegetative phase

Methods:
Fresh roots were hand-sectioned, and thin sections were observed under the
microscope to locate the presence of mycorrhiza. Simultaneously, to observe the expansion
of mycorrhiza in the cortical region.

Results:
During the vegetative phase of plant growth, a peloton-like structure forms within
the cortical region of the orchid roots. Mycorrhizae was observed to be distributed
throughout the cortical layer of the root.

Conclusion:
This communication reviews the role of mycorrhiza in orchid plants.
The Landscape of Products for Diabetic Peripheral Neuropathy: A Scientific and Patent Systematic Review
Authors: dos Santos Barros Giselda , dos Passos Menezes Paula , de Cassia Silva Simone , da Silva Gabriel Francisco 
Published: August 2024

Background:
Diabetic peripheral neuropathy (DPN) is a complication of diabetes
that occurs in 40 - 60 million individuals worldwide and is associated with other
chronic diseases. However, there are no review studies that present the state-of- the- art
and technologies developed to circumvent this important health problem.

Material and Methods:
This review was conducted based on scientific papers and patents.
The papers were retrieved from Lilacs, PubMed, and Web of Science databases,
and the patents from INPI, ESPACENET, WIPO, and GOOGLE PATENTS. Thus, a
sample consisting of 14 scientific articles and 667 patents was analyzed.

Results:
From the analysis of the data, we drew an overview of the development of biomedical
technologies for DPN and detected the pioneering spirit of China, the USA, and
Japan in the area, with a focus on the treatment of DPN. Based on this, we carried out a
SWOT analysis to help direct future efforts in the area, which should focus primarily on
developing technologies for prevention, early diagnosis, and, above all, cure of the disease
to reduce the important impact of this disease in various sectors of society.

Conclusion:
This study finds a concentration of diabetic peripheral neuropathy products,
especially therapeutic drugs, in high-income countries. It highlights the need for global
collaboration and strategic focus on therapeutic adherence and preventive strategies to
effectively manage DPN.
Horizontal Augmentation Using Customized Zirconia Membrane: A Case Report
Authors: Albash Ziad , Abdallah Yamen , Moawad Shadi , Khalil Ali , Assad Mounzer , Noureddin Hassan 
Published: August 2024

Background
Horizontal bone defects are frequently observed after tooth extraction, primarily resulting from the physiological resorption of the alveolar ridge. Reconstruction of horizontal defects is essential before or during dental implant placement, particularly in the esthetic zone. This case report aims to evaluate the effectiveness of horizontal alveolar ridge augmentation utilizing a customized zirconia membrane.

Case Presentation
A 20-year-old female patient desired to replace the missing right upper central incisor with a dental implant. The radiographic evaluation showed a concave bone defect, which makes it impossible to place a dental implant. The treatment plan was made for localized ridge augmentation using a customized zirconia membrane (CZM) prior to dental implant placement.

Conclusion
The customized Zirconia membrane is an effective and very satisfactory treatment option in the management of horizontal defects. Customized zirconia membranes reduce surgical time, facilitate the procedure for the patient and the practitioner, reduce the rate of complications, and achieve good horizontal bone gain.
Mental Health Issues Among Adolescents: Challenges and Management
Authors: Kumar Saurabh , Kumar Krishan , Avti Pramod , Anand Akshay 
Published: August 2024

Abstract:
Adolescence is an important stage of life between childhood and adulthood. The
shift in lifestyle, physical inactivity, high expectations of family/friends/teachers, and continuous
exposure to social media and the internet have created physical, social, emotional, and
mental imbalances in adolescents. The individuals of this age group are vulnerable and exposed
to these stressful factors, leading to psychological complications. Most psychological problems
diagnosed in the later stages of life begin in adolescence. The purpose of this mini-review was
to identify mental health problems and available non-pharmacological interventions to manage
the overall well-being of adolescents. A literature search was conducted to identify relevant
studies, including research, review, and other articles/data available on PubMed, Google
Scholar, ScienceDirect, WHO, GHDx, and AACAP. Search keys included essential keywords
like adolescence, yoga, mental health, anxiety, depression, and a combination of these words.
The literature search identified several mental disorders like emotional, behavioral, identity,
psychosis, dietary, and other risky behaviors. Most of these non-pharmacological interventions
adopted focused on improving the mental and physical well-being in school and community
settings. Among all the interventions, we found yoga to be the most popular and widely accepted
effective tool that reduces anxiety, depression, and psychological problems. Yoga also improved
resilience, attention, and other well-being parameters. Yoga helps manage physical and
mental health in adolescence.
PENGARUH DANA PIHAK KETIGA (DPK), CAPITAL ADEQUACY RATIO (CAR), NON PERFORMING LOAN (NPL), NET INTEREST MARGIN (NIM), DAN LOAN TO DEPOSIT RATIO (LDR) TERHADAP PENYALURAN KREDIT
Authors: Sudimoro Family Syafira Tauhida Qulby 
Published: August 2024

Banking is an important part that plays a role in the economic development of a country. Banking also functions as an intermediary institutions whose job is to collect funds from the public and channel them back to the community in the form of credit. In extending credit, there are internal factors that must be considered, namely the activities of banks collecting public funds are indicated by the amount of DPK, from the capital side it is indicated by CAR, the level of collectibility is indicated by NPL, the level of bank operational efficiency is indicated by NIM, and from a banking liquidity perspective indicated by LDR. This study aims to determine the effect of Third Party Funds (DPK), Capital Adequacy Ratio (CAR), Non Performing Loans (NPL), Net Interest Margin (NIM), and Loan to Deposit Ratio (LDR) on bank lending listed on the Stock Exchange. Indonesian securities for the 2012-2021 period using the purposive sampling method. The analytical method uses panel data regression. The results showed that DPK, CAR, NIM, and LDR had a positive and significant effect on lending. Meanwhile, NPL has a significant negative effect on lending.
Keywords: Lending, DPK, CAR, NPL, NIM, LDR
DIGITALISASI DAN PENGANGGURAN DI PEDESAAN JAWA TIMUR PADA MASA PANDEMI COVID-19 (STUDI KASUS PADA SEKTOR INFORMAL)
Authors: Mawarni Sherina Indah , Syafitri Wildan 
Published: August 2024

The COVID-19 pandemic has caused unemployment increase, but COVID-19 has also provided a digital acceleration boost. In 2020 East Java has highest rate of digital literacy. Using SAKERNAS 2020 data, This study employs logistic regression to determine how East Java's unemployment is affected by digitalization. This study indicated that East Java's unemployment rate was significantly and negatively impacted by digitization. Workers who can master information technology through use of the internet will have an impact on have a smaller tendency to become unemployed than those who cannot use the internet. In addition, other factors such as area of residence, employment sector, gender, training, pre-employment card ownership, education and migration also affect the tendency of the workforce to become unemployed.
Pengaruh Service Quality, Customer Perceived Value, dan Customer Trust Terhadap Customer Loyalty
Authors: Al-Qadrie Muhammad Nur Mi'raj 
Published: August 2024

Major changes have been made since the outbreak of the COVID-19 pandemic, several companies have collapsed and some have survived and even made profits. Changes in the dynamics of demand for the situation at hand bring new business models developing faster than they should, thus driving significant change. One of the industries affected is online food and one of the concepts is cloud kitchen. This study aims to analyze the effect of service quality, customer perceived value, and customer trust on customer loyalty cloud kitchen Kleise. The questionnaire was used to collect data from users of the Kleise cloud kitchen service with a total of 142 respondents. Data analysis using SPSS from IBM. The results of this study shows there are no influence of service quality variables on customer loyalty and yet the relationship is inversely or negatively related. Conversely, the customer perceived value and customer trust variables show a significant influence with a positive or unidirectional relationship. From the results of this study the authors can provide suggestions to focus on perceived value and trust in running the Kleise cloud kitchen business operations in order to increase customer loyalty.

Abstrak
Perubahan secara besar dilakukan semenjak terjadinya wabah pandemi COVID-19, ada beberapa perusahaan yang collapse dan ada juga yang bertahan bahkan meraup keuntungan. Perubahan dinamika permintaan aka situasi yang dihadapi membawa model bisnis baru berkembang lebih cepat dari semestinya sehingga mendorong perubahan secara signifikan. Salah satu industri yang terkena dampak adalah online food dan salah satu konsepnya adalah cloud kitchen. Penelitian ini bertujuan untuk menganalisa pengaruh service quality, customer perceived value, dan customer trust terhadap customer loyalty cloud kitchen Kleise. Kuesioner digunakan untuk mengumpulkan data dari pengguna layanan cloud kitchen Kleise dengan total partisipan sebanyak 142 responden. Analisis data menggunakan SPSS dari IBM. Hasil dari penelitian ini adalah tidak adanya pengaruh dari variabel service quality terhadap customer loyalty dan hubungannya berbanding terbalik atau negatif. Sebaliknya variabel customer perceived value dan customer trust menunjukkan pengaruh yang signifikan dengan hubungan positif atau searah. Dari hasil penelitian ini penulis dapat memberikan saran untuk fokus terhadap perceived value dan trust dalam menjalankan operasional usaha cloud kitchen Kleise agar dapat meningkatkan customer loyalty.
The Effect of Product Quality and Service Quality on Customer Satisfaction at Bank Sinarmas
Authors: Aulia Alif Izzah , Rofiaty Rofiaty 
Published: August 2024

The purpose of this research is to identify the effects of product quality and service quality on the satisfaction of Bank Sinarmas’ customers. The effect to be identified is the direct effect of product quality and service quality on satisfaction. This explanatory research explains the causal relationship between variables through hypothesis testing. The sample of this research is 112 respondents who were selected using purposive sampling with the criteria of the customers of Bank Sinarmas. The assessment tools used in this study are research instrument test and classical assumption test performed in SPSS. The results of the analysis indicate that product quality and service quality can enhance customer satisfaction.

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh kualitas produk, dan kualitas pelayanan, terhadap kepuasan nasabah Bank Sinarmas. Pengaruh yang ingin diketahui adalah pengaruh langsung kualitas produk, dan kualitas pelayanan, terhadap kepuasan. Jenis penelitian ini adalah explanatory research yang menjelaskan hubungan kausal antara variabel-variabel melalui pengujian hipotesis. Penelitian ini menggunakan sampel sebanyak 112 responden. Pengambilan sampel menggunakan purposive sampling dengan karakteristik merupakan nasabah Bank Sinarmas. Alat uji yang digunakan adalah uji instrumen penelitian dan uji asumsi klasik menggunakan program SPSS. Dari hasil pengujian ini dapat disimpulkan bahwa kualitas produk dan kualitas pelayanan dapat mendorong kepuasan nasabah.
Pengaruh Celebrity Endorsement, EWOM, dan Limited Edition Product Terhadap Purchase Intention
Authors: Agustin Tika , Hakim Abdurrahman 
Published: August 2024

The objective of this research is to identify the effects of Song Joong-ki’s celebrity endorsement, electronic word-of-mouth, and Song Joong-ki limited edition product on the intention of Indonesian Generation Z to purchase Scarlett Whitening. This explanatory research elucidates and proves the relationship between independent and dependent variables. Using non-probability sampling method and purposive sampling technique, 250 people were selected as the respondents. The data of this study was harvested from Google Forms questionnaires and was analyzed using multiple linear regression in SPSS version 29. This study finds that Song Joong-ki’s celebrity endorsement positively yet insignificantly influences the purchase intention, that electronic word-of-mouth positively and significantly influences the purchase intention, and that Song Joong-ki limited edition product positively and significantly impacts the purchase intention. Furthermore, Song Joong-ki’s celebrity endorsement, electronic word-of-mouth, and Song Joong-ki limited edition product simultaneously do not contribute to the purchase intention.

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh celebrity endorsement Song Joong-ki, electronic word of mouth dan Song Joong-ki limited edition product terhadap purchase intention generasi z pada Scarlett Whitening di Indonesia. Jenis penelitian ini adalah explanatory research yang menjelaskan atau membuktikan hubungan atau pengaruh antar variabel independen dan dependen. Penelitian ini menggunakan sampel sebanyak 250 responden dimana penyebaran kuesioner dilaksakan menggunakan google form. Pengambilan sampel menggunakan metode non-probability sampling dengan teknik purposive sampling. Analisis data menggunakan Analisis Regresi Linier Berganda dengan menggunakan SPSS ver. 29. Hasil analisis yang didapat dalam penelitian ini adalah celebrity endorsement Song Joong-ki memiliki pengaruh yang positif namun tidak signifikan terhadap purchase intention, electronic word of mouth berpengaruh positif dan signifikan terhadap purchase intention, Song Joong-ki limited edition product berpengaruh positif dan signifikan terhadap purchase intention, dan celebrity endorsement Song Joong-ki, electronic word of mouth, Song Joong-ki limited edition product secara bersama-sama tidak memiliki kontribusi terhadap Purchase Intention.
Perbedaan Persepsi Atas Expertise Psikolog Dan Pengaruhnya Terhadap Customer Satisfaction
Authors: Kamila Cintia Okta , Hendrawan Dimas 
Published: August 2024

The aim of this research is to analyze the difference in expertise between psychologists Dian and Putri on customer satisfaction at the Psychology Service Bureau (BLP) Lentera and Bunga. This explanatory research aims to explain and analyze the relationship between the research variable expertise and customer satisfaction. The research method is used to understand the cause-and-effect relationship between variables in the study. The research uses a sample of 50 respondents taken from the BLP Lentera and BLP Bunga client populations using purposive sampling. The sample characteristics selected are clients who are at least 19-40 years old and have undergone counseling with psychologists Dian and Putri at BLP Lentera or BLP Bunga, both offline and online. The data analysis technique in this study uses a difference test, supported by Validity Test, Reliability Test, and Simple Linear Regression Test. The hypothesis test is conducted using the t-test with the SPSS 26 program. The results show that there is a significant difference in the expertise of psychologists Dian and Putri on customer satisfaction. Furthermore, there is a significant influence between consumer perceptions of the expertise of psychologists Dian and Putri on customer satisfaction.

Abstrak
Penelitian ini bertujuan untuk menganalisis perbedaan expertise psikolog Dian dan psikolog Putri terhadap customer satisfaction pada Biro Layanan Psikologi (BLP) Lentera dan Bunga. Jenis penelitian ini adalah explanatory research yang bertujuan untuk menjelaskan dan menganalisis hubungan antara variabel expertise penelitian dengan customer satisfaction. Metode ini digunakan untuk memahami hubungan sebab-akibat antar variabel dalam penelitian. Penelitian ini menggunakan sampel sebanyak 50 responden yang diambil populasi klien BLP Lentera dan BLP Bunga. Pengambilan sampel menggunakan teknik non-probability sampling yaitu purposive sampling. Karakteristik sampel yang dipilih yaitu, minimal berusia 19 – 40 tahun dan klien yang pernah melakukan konseling bersama psikolog Dian dan psikolog Putri di BLP Lentera maupun BLP Bunga, baik konseling secara offline maupun online. Teknik analisis data dalam penelitian ini menggunakan uji beda, yang ditunjang dengan Uji Validitas, Uji Reliabillitas, dan Uji Linear Regresi Sederhana. Uji hipotesis dilakukan menggunakan Uji-t dengan menggunakan program SPSS 26. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang signifikan atas expertise psikolog Dian dan Psikolog Putri terhadap customer satisfaction. Kemudian terdapat pengaruh signifikan antara persepsi konsumen atas expertise psikolog Dian dan psikolog Putri terhadap customer satisfaction.