bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human liver stem cells and derived extracellular vesicles improve recovery in a murine model of acute kidney injury
Authors: Sanchez Maria Beatriz Herrera , Bruno Stefania , Grange Cristina , Tapparo Marta , Cantaluppi Vincenzo , Tetta Ciro , Camussi Giovanni 
Published: November 2014

Abstract
Introduction
Several cellular sources of stem cells have been tested in the attempt to yield innovative interventions in acute kidney injury (AKI). Human liver stem cells (HLSCs) are cells isolated from the normal adult human liver which are gaining attention for their therapeutic potential. In the present study, we investigated whether HLSCs and the derived extracellular vesicles may promote tubular regeneration after AKI induced by glycerol injection in severe-combined immune-deficient mice.

Methods
HLSCs were expanded and conditioned medium (CM) and extracellular vesicles (EVs) were purified. HLSCs and their bioproducts were tested in a model of AKI induced by intra-muscle glycerol injection. Renal function and morphology were evaluated five days after induction of damage. The effect of EVs on proliferation and apoptosis of murine renal tubular cells was tested in vitro.

Results
We found that intravenous injection of 3.5×105 HLSCs into mice three days after induction of AKI significantly improved functional and morphological recovery. The injection of HLSCs decreased creatinine and urea, as well as hyaline cast formation, tubular necrosis and enhanced in vivo tubular cell proliferation. The effect of soluble factors release by HLSCs in the regenerative processes was also studied. CM produced by HLSCs, mimicked the effect of the cells. However, depletion of EVs significantly reduced the functional and morphological recovery of CM. Moreover, we found that purified HLSC-derived EVs ameliorated renal function and morphology in a manner comparable to the cells. In vitro HLSC-derived EVs were shown to stimulate proliferation and inhibit apoptosis of murine renal tubular cells.

Conclusions
These results indicate that HLSCs increase recovery after AKI. EVs are the main component of HLSC-derived CM capable of promoting regeneration in experimental AKI.
Randomized Phase III Trial of Amrubicin Versus Topotecan As Second-Line Treatment for Patients With Small-Cell Lung Cancer
Authors: von Pawel Joachim , Jotte Robert , Spigel David R. , O'Brien Mary E.R. , Socinski Mark A. , Mezger Jörg , Steins Martin , Bosquée Léon , Bubis Jeffrey , Nackaerts Kristiaan , Trigo José M. , Clingan Philip , Schütte Wolfgang , Lorigan Paul , Reck Martin , Domine Manuel , Shepherd Frances A. , Li Shaoyi , Renschler Markus F. 
Published: November 2014

Purpose Amrubicin, a third-generation anthracycline and potent topoisomerase II inhibitor, showed promising activity in small-cell lung cancer (SCLC) in phase II trials. This phase III trial compared the safety and efficacy of amrubicin versus topotecan as second-line treatment for SCLC. Patients and Methods A total of 637 patients with refractory or sensitive SCLC were randomly assigned at a ratio of 2:1 to 21-day cycles of amrubicin 40 mg/m2 intravenously (IV) on days 1 to 3 or topotecan 1.5 mg/m2 IV on days 1 to 5. Primary end point was overall survival (OS); secondary end points included overall response rate (ORR), progression-free survival (PFS), and safety. Results Median OS was 7.5 months with amrubicin versus 7.8 months with topotecan (hazard ratio [HR], 0.880; P = .170); in refractory patients, median OS was 6.2 and 5.7 months, respectively (HR, 0.77; P = .047). Median PFS was 4.1 months with amrubicin and 3.5 months with topotecan (HR, 0.802; P = .018). ORR was 31.1% with amrubicin and 16.9% with topotecan (odds ratio, 2.223; P < .001). Grade ≥ 3 treatment-emergent adverse events in the amrubicin and topotecan arms were: neutropenia (41% v 54%; P = .004), thrombocytopenia (21% v 54%; P < .001), anemia (16% v 31%; P < .001), infections (16% v 10%; P = .043), febrile neutropenia (10% v 3%; P = .003), and cardiac disorders (5% v 5%; P = .759); transfusion rates were 32% and 53% (P < .001), respectively. NQO1 polymorphisms did not influence safety outcomes. Conclusion Amrubicin did not improve survival when compared with topotecan in the second-line treatment of patients with SCLC. OS did not differ significantly between treatment groups, although an improvement in OS was noted in patients with refractory disease treated with amrubicin.
Young Patients With Non–Germinal Center B-Cell–Like Diffuse Large B-Cell Lymphoma Benefit From Intensified Chemotherapy With ACVBP Plus Rituximab Compared With CHOP Plus Rituximab: Analysis of Data From the Groupe d'Etudes des Lymphomes de l'Adulte/Lymphoma Study Association Phase III Trial LNH 03-2B
Authors: Molina Thierry Jo , Canioni Danielle , Copie-Bergman Christiane , Recher Christian , Brière Josette , Haioun Corinne , Berger Françoise , Fermé Christophe , Copin Marie-Christine , Casasnovas Olivier , Thieblemont Catherine , Petrella Tony , Leroy Karen , Salles Gilles , Fabiani Bettina , Morschauser Franck , Mounier Nicolas , Coiffier Bertrand , Jardin Fabrice , Gaulard Philippe , Jais Jean-Philippe , Tilly Hervé 
Published: November 2014

Purpose To determine whether any tumor biomarkers could account for the survival advantage observed in the LNH 03-2B trial among patients with diffuse large B-cell lymphoma (DLBCL) and low-intermediate risk according to the International Prognostic Index when treated with dose-intensive rituximab, doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone (R-ACVBP) compared with standard rituximab, doxorubicin, cyclophosphamide, vincristine, and prednisone (R-CHOP). Patients and Methods Using immunohistochemistry, expression of CD10, BCL6, MUM1, MYC, and BCL2 and coexpression of MYC/BCL2 were examined. The interaction effects between each biomarker and treatment arm on survival were studied in a restricted model and a full model incorporating clinical parameters. Results Among the 379 patients analyzed in the trial, 229 tumors were evaluable for germinal center B-cell–like (GCB)/non-GCB subclassification according to the Hans algorithm. Among all the biomarkers, only the interaction between the Hans algorithm and the treatment arm was significant for progression-free survival (PFS) and overall survival (OS) in univariable (PFS, P = .04; OS, P = .01) and multivariable (PFS, P = .03; OS, P = .01) analyses. Non-GCB tumors predicted worse PFS (hazard ratio [HR], 3.21; 95% CI, 1.29 to 8.00; P = .01) and OS (HR, 6.09; 95% CI, 1.37 to 27.03; P = .02) among patients treated with R-CHOP compared with patients who received R-ACVBP, whereas there were no significant survival differences between these regimens among patients with GCB tumors. Conclusion The survival benefit related to R-ACVBP over R-CHOP is at least partly linked to improved survival among patients with non-GCB DLBCL. Therefore, the Hans algorithm could be considered a theragnostic biomarker for selecting young patients with DLBCL who can benefit from an intensified R-ACVBP immunochemotherapy regimen.
Identification of Independent Primary Tumors and Intrapulmonary Metastases Using DNA Rearrangements in Non–Small-Cell Lung Cancer
Authors: Murphy Stephen J. , Aubry Marie-Christine , Harris Faye R. , Halling Geoffrey C. , Johnson Sarah H. , Terra Simone , Drucker Travis M. , Asiedu Michael K. , Kipp Benjamin R. , Yi Eunhee S. , Peikert Tobias , Yang Ping , Vasmatzis George , Wigle Dennis A. 
Published: November 2014

Purpose Distinguishing independent primary tumors from intrapulmonary metastases in non–small-cell carcinoma remains a clinical dilemma with significant clinical implications. Using next-generation DNA sequencing, we developed a chromosomal rearrangement–based approach to differentiate multiple primary tumors from metastasis. Methods Tumor specimens from patients with known independent primary tumors and metastatic lesions were used for lineage test development, which was then applied to multifocal tumors. Laser capture microdissection was performed separately for each tumor. Genomic DNA was isolated using direct in situ whole-genome amplification methodology, and next-generation sequencing was performed using an Illumina mate-pair library protocol. Sequence reads were mapped to the human genome, and primers spanning the fusion junctions were used for validation polymerase chain reaction. Results A total of 41 tumor samples were sequenced (33 adenocarcinomas [ADs] and eight squamous cell carcinomas [SQCCs]), with a range of three to 276 breakpoints per tumor identified. Lung tumors predicted to be independent primary tumors based on different histologic subtype did not share any genomic rearrangements. In patients with lung primary tumors and paired distant metastases, shared rearrangements were identified in all tumor pairs, emphasizing the patient specificity of identified breakpoints. Multifocal AD and SQCC samples were reviewed independently by two pulmonary pathologists. Concordance between histology and genomic data occurred in the majority of samples. Discrepant tumor samples were resolved by genome sequencing. Conclusion A diagnostic lineage test based on genomic rearrangements from mate-pair sequencing demonstrates promise for distinguishing independent primary from metastatic disease in lung cancer.
Author Financial Conflicts of Interest, Industry Funding, and Clinical Practice Guidelines for Anticancer Drugs
Authors: Tibau Ariadna , Bedard Philippe L. , Srikanthan Amirrtha , Ethier Josee-Lyne , Vera-Badillo Francisco E. , Templeton Arnoud J. , Ocaña Alberto , Seruga Bostjan , Barnadas Agustí , Amir Eitan 
Published: November 2014

Purpose Clinical practice guidelines (CPGs) and consensus statements (CSs) are used to apply evidence-based medicine or expert recommendations to clinical practice. Here we explore author financial conflicts of interest (FCOIs), sources of guideline funding, and their relationship with endorsement of specific drugs. Methods An electronic search of MEDLINE was conducted to identify CPGs and CSs for common solid cancers published between January 2003 and October 2013. The search was restricted to articles evaluating systemic therapy. We extracted data on self-reported author FCOIs, funding sources, use of manuscript writers, and endorsement of specific drugs in the abstract of the article. Results Of 142 articles evaluated, 64% were CPGs, and 36% were CSs. The proportion of articles reporting FCOIs improved from 11% in 2003 to 93% in 2013 (P for trend < .001). Only 45% of articles explicitly reported funding sources. Of these, 65% disclosed partial or full industry sponsorship. Use of manuscript writers was declared in 13%, but many articles did not explicitly report the role of authors in the writing of the manuscript. Endorsement of specific drugs was significantly associated with author FCOIs (odds ratio [OR], 7.29; P = .001), but not with industry funding (OR, 0.95; P = .37). Conclusion Reporting of FCOIs in CPGs and CSs has improved over time. Despite prevalent funding of guideline development by industry, such funding is not associated with endorsement of specific drugs. Author FCOIs are prevalent, and endorsement of a specific drug seems to be more common when authors have FCOIs with the pharmaceutical company marketing that drug.
Recent Developments in Organocatalyzed Electroorganic Chemistry
Authors: Ogawa Kelli A , Boydston Andrew J 
Published: November 2014

Abstract
This highlight review focuses on the integration of organocatalysis and electrosynthesis. Specifically, we detail recent advances involving the use of organocatalysts to alter substrate redox potentials through the in situ generation of electroactive intermediates. The ability to redirect organocatalyzed pathways toward oxidative fates using electrolysis techniques has enabled highly efficient transformations that would traditionally require stoichiometric sacrificial oxidants.
Evaluation of Technogenic Impact on Hydrochemistry of the Teberda River
Authors: Онищенко  , Onishchenko V. , Дега  , Dega Natalya , Байчорова  , Baychorova E. 
Published: November 2014

The paper presents research results for water chemistry of one of the Karachay-Cherkessia largest rivers – Teberda. Authors
apply contemporary techniques of comprehensive assessment of surface water contamination in mountain rivers under the
influence of technogenic and recreational factors. No similar research has been previously conducted. The research reveals
features of distribution of basic elements and compounds levels between separate river sites in anthropogenic areas.
Analytical Model of Suspensions Separation in Hydrodynamic Filter with Pivoting Perforated Partition
Authors: Мягков  , Myagkov I. , Львов  , Lvov V. , Девисилов  , Devisilov Vladimir , Шарай  , Sharay E. 
Published: November 2014

The article develops a stochastic model of suspensions separation in hydrodynamic filter. Suspensions separation in the
filter is carried out due to hydrodynamic force action on suspension flow (first stage of separation) and filtering through a
porous membrane (second stage). Pivoting perforated partition is put into filter in front of the porous filtering membrane
to increase effectiveness of suspensions separation at stage one. Complex Couette flow develops in the gap between
filter bowl and the perforated partition. Specific modes of flow in the gap produce Taylor vortex, size and intensity of
which depend on parti-tion’s rotation speed and flow velocity. It produces a flow currently known as Couette-Taylor flow.
Multidirectional Taylor vortex arising in the mainstream disrupts its hydrodynamics and creates turbulence. Given such
flow, calculation of hard phase separation with use of determinate models can be an error as does not include stochastic
processes. The article presents a new analytical model of suspensions separation, which takes in stochastic (probabilistic)
separation processes and is based on the theory of Markovian processes. Equations of diffusion type, particularly the
Fokker-Planck-Kolmogorov equation, are offered to describe process of suspensions separation in hydrodynamic filters with
pivoting perforated partition.
Disaster cosmopolitanism: Catastrophe and global community in the fiction of Daniel Maximin and Maryse Condé
Authors: Brant Daniel 
Published: November 2014

Abstract
This article examines how Guadeloupean novelists Daniel Maximin and Maryse Condé – the former in L’Isolé soleil ([1981] 2001) and Soufrières ([1987] 2004) and the latter in En attendant la montée des eaux (2010) – articulate a ‘disaster cosmopolitanism’ in response to global catastrophes and suffering. Through close readings of these novels, this article explores how each author actualizes a framework for global solidarity beyond a purely French or Francophone scope in a world where the risk of catastrophe is ubiquitous. It argues that in these novels Maximin and Condé outline a global ‘disasterscape’ in which catastrophe becomes the link between different peoples and cultures across the world. Disaster cosmopolitanism imagines, then, globalization in terms of geographies of solidarity rather than neo-liberal economic competition. Incorporating humanitarian action into its response, disaster cosmopolitanism makes risk and catastrophe fundamental conditions of contemporary society and thinks about catastrophes relationally by drawing disparate peoples and regions together in the recognition of and shared responsibility for financial, ecological and technological risks and vulnerabilities.
Cet article examine la manière dont les romanciers guadeloupéens Daniel Maximin et Maryse Condé – le premier dans L’Isolé soleil ([1981] 2001) et Soufrières ([1987] 2004), la seconde dans En attendant la montée des eaux (2010) – articulent un ‘cosmopolitisme du désastre’ face à la souffrance et aux catastrophes mondiales. A travers des lectures détaillées de ces romans, cet article analyse comment les auteurs pensent la solidarité au-delà des contextes français et francophone dans un monde où le risque de catastrophes est omniprésent. Il soutient que Maximin et Condé tracent dans leurs romans les contours d’un ‘paysage’ mondial de désastres dans lequel les catastrophes deviennent un lien important entre peuples et cultures disparates. Le cosmopolitisme du désastre revient donc à imaginer la mondialisation comme un ensemble de géographies de solidarités au lieu de la concurrence économique acharnée que prône le néolibéralisme. Tout en intégrant l’action humanitaire à sa réponse, le cosmopolitisme du désastre fait du risque et des catastrophes des conditions fondamentales de la société contemporaine. Ainsi propose-t-il de penser les catastrophes de manière relationnelle afin de relier des peuples et des régions différents aussi bien autour de la reconnaissance que de la responsabilité partagée des risques et des vulnérabilités financiers, écologiques et technologiques.
AmmanNet (Al-Balad) Internet radio in Jordan and the West Bank: or, ‘I have seen the future of radio, and it is AmmanNet’
Authors: Najjar Orayb 
Published: November 2014

Abstract
Arab states have used terrestrial radio for nationalist mobilization and development extensively in the 1950s and 1960s. However, government restrictions, combined with the high cost of terrestrial broadcasting, kept radio out of private hands. After discussing the technological context that made digital radio possible in Jordan and the West Bank, I trace the development of the first Internet radio station in the Arab world, AmmanNet, and describe its developmental local programming as an example of a new type of media that digitally savvy youth are broadcasting. However, because some of the funding comes from NGOs (non-governmental organizations) and foreign governments, Arabs face a dilemma: accepting such funding provides them with equipment and training they may not otherwise have, but accepting it sometimes restricts their programming choices to discussions of local problems, rather than problems created by the Israeli occupation. Yet foreign funding also provides opportunities to discuss taboo social issues that state media rarely consider airing.
Nigerian or British: Muslim identity and the framing of Umar Farouk Abdulmutallab in the British press
Authors: Yusha’u Muhammad Jameel 
Published: November 2014

Abstract
The story of Umar Farouk Abdulmutallab’s alleged attempt to blow up a US airliner on 25 December 2009 received a lot of attention in the media. As the story developed it appeared that Umar Farouk studied in the United Kingdom and was resident in the country. Although Nigerian by birth, he received his education either in Britain or in British institutions. The nature of his upbringing and education raises questions about his identity. So how was the story framed in the British press? How was the story reported in relation to the representation of Muslims in the British press? This article studied the representation of the Umar Farouk Abdulmutallab story in four British newspapers: The Guardian, The Telegraph, The Times and The Independent. These newspapers are among the quality press in the United Kingdom, and are read not only in the United Kingdom but across the world. Using the framing theory to provide a critique of the coverage of this story in the British press within the context of representation of identity, the research found that although there are ideological differences between the liberal and the conservative press in Britain, they share similarities when it comes to reporting stories that relate to Muslims. The findings of this research suggested that there are three key frames that shaped the reporting of the story in the British broadsheets. The frames are Muslim identity, Nigerian citizenship and British education. All the newspapers under study paid significant attention to these frames, while being silent on the main causes of radicalization. A common feature from the newspapers under study is the commonality in reporting between the conservative and the liberal press.
Atypical presentation and manifestations in X-linked agammaglobulinemia patients with novelBTKmutations
Authors: Nahum Amit , Manson David , Ngan Bo 
Published: November 2014

X-linked agammaglobulinemia (XLA) is a rare immunodeficiency caused by defects in the Bruton tyrosine kinase (BTK) gene, characterized by impaired B-cell development, reduced immunoglobulin production, and increased susceptibility to bacterial infections at an early age. Some XLA patients show atypical presentations, with most reports concentrating on the diagnosis at a relatively old age. They presented with infections at late age or with unusual pathogens; however, other atypical manifestations have only rarely been reported.Methods: Description of patients with XLA and novel mutations in BTK who presented with atypical manifestations or developed noninfectious complications.Results: Four patients presented unique manifestations unusual for XLA. The first with Granulomatous Dermatitis, the second with acute demyelinating encephalomyelitis, the third with “Crohn's disease like” localized protein-losing enteropathy, and the last patient with idiopathic thrombocytopenic purpura, which is an unexpected finding in a patient devoid of endogenous immunoglobulins. Mutations in BTK were found in all domains of the gene; 1 resulted in a stop codon and 3 were missense mutations.Conclusions: Early recognition of atypical presentations and manifestations of patients with XLA is crucial for timely initiation of life-saving therapy, which may include anti-bacterial and anti-inflammatory treatments in addition to immunoglobulin.Statement of novelty: In this study we present unique inflammatory and autoimmune phenomenons in XLA patients that were not described previously and are somewhat unexpected. These should alert the immunologist for the possibility of XLA diagnosis.
Splicing knot complements and bordered Floer homology
Authors: Hedden Matthew , Levine Adam Simon 
Published: November 2014

Abstract
We show that the integer homology sphere obtained by splicing two nontrivial knot complements in integer homology sphere L-spaces has Heegaard Floer homology of rank strictly greater than one. In particular, splicing the complements of nontrivial knots in the 3-sphere never produces an L-space. The proof uses bordered Floer homology.
Hydrogenolysis of lignin in ZnCl2 and KCl as an inorganic molten salt medium
Authors: Appelt Jörn , Gohrbandt Anne , Peters Jana , Bremer Martina , Fischer Steffen 
Published: November 2014

Abstract
Lignin can be converted into monomeric products with the aid of molten salt media. Molten zinc chloride (ZnCl2)/potassium chloride (KCl) mixtures are suitable for this purpose. The application of an eutectic mixture with low melting points leads to similar main products as are obtained by pyrolysis. The hydrogenolysis of an organosolv lignin in molten salts of ZnCl2/KCl was investigated as a function of reaction temperature, residence time, and lignin concentration, and the composition of liquid products and monophenols was analyzed by gas chromatography-mass spectrometry (GC-MS). The yields can be optimized by the proper selection of the reaction temperature. A longer residence time and higher lignin concentrations lead to increased formation of solid residues and gaseous products. The liquid products mainly consist of substituted phenols derived from lignins. Polymeric products are the result of condensation reactions (i.e., the formation of new C-C linkages in the course of secondary reactions).