bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Smoking History with Cancer Recurrence and Survival in Stage III–IV Male Gastric Cancer Patients
Authors: Han Mi Ah , Kim Young-Woo , Choi Il Ju , Oh Myueng Guen , Kim Chan Gyoo , Lee Jong Yeul , Cho Soo-Jeong , Eom Bang Wool , Yoon Hong Man , Ryu Keun Won 
Published: August 2013

Abstract
Background: Smoking and drinking alcohol are major risk factors for cancer development, and we investigated their effects on gastric cancer prognosis following initial resection.
Methods: Data from male patients with stage III–IV gastric adenocarcinoma who underwent surgery between 2001 and 2006 were retrospectively reviewed. Patients were followed up until 2011. Kaplan–Meier plots and Cox proportional hazards regressions were applied for survival rates.
Results: Among 238 patients, 151 (63.4%) smoked and 146 (61.3%) drank alcohol. Current smokers had an increased risk of cancer recurrence or death from any cause [adjusted HR (aHR), 1.94; 95% confidence interval (CI), 1.18–3.21], cancer recurrence (aHR, 1.89; 95% CI, 1.12–3.21), and overall mortality (aHR, 2.14; 95% CI, 1.23–3.73) compared with never-smokers. Patients with a lifetime cigarette smoking of &lt;40 and ≥40 pack-years had increased cancer recurrence or death from any cause (aHR, 1.72 and 2.43, respectively; 95% CI, 1.03–2.86 and 1.38–4.30, respectively), cancer recurrence (aHR, 1.63 and 2.61, respectively; 95% CI, 0.95–2.79 and 1.43–4.77, respectively), and overall mortality (aHR, 1.92 and 2.75, respectively; 95% CI, 1.09–3.38 and 1.47–5.12, respectively) compared with never-smokers. However, drinking alcohol was not associated with postsurgery survival.
Conclusions: Cigarette-smoking history at the time of diagnosis, but not drinking history, is associated with cancer recurrence and poor survival after surgery in male patients with stage III–IV gastric cancer.
Impact: These findings encourage physicians to advise patients with gastric cancer to stop smoking to obtain a general health benefit and likely improvement in the gastric cancer course. Cancer Epidemiol Biomarkers Prev; 22(10); 1805–12. ©2013 AACR.
Risk Assessment of Esophageal Adenocarcinoma Using γ-H2AX Assay
Authors: Xu Enping , Gong Yilei , Gu Jian , Jie Lin , Ajani Jaffer A. , Wu Xifeng 
Published: August 2013

Abstract
Background: Mutagen-induced DNA damage as measured in peripheral blood lymphocytes (PBL) has been associated with increased risks of cancers. The formation of γ-H2AX is an early cellular response to DNA double-strand breaks (DSB). We hypothesize that higher level of radiation-induced γ-H2AX in PBLs may be associated with an increased risk of esophageal adenocarcinoma.
Methods: Laser scanning cytometer-based immunocytochemical method was used to measure baseline and irradiation-induced γ-H2AX levels in PBLs from 211 patients with esophageal adenocarcinoma and 211 healthy controls. The ratio of induced γ-H2AX level to baseline level was used to evaluate individual susceptibility to DSBs. Relative risks for esophageal adenocarcinoma associated with γ-H2AX were assessed by multivariable logistic regression analysis.
Results: Radiation-induced γ-H2AX level and the γ-H2AX ratio were significantly higher in cases than in controls. Dichotomized at the median in controls, a significantly increased risk for esophageal adenocarcinoma was observed in association with high γ-H2AX ratio [OR = 2.94; 95% confidence interval (CI), 1.83–4.72]. Quartile analyses showed significant dose–response associations between higher γ-H2AX ratio and increased risk of esophageal adenocarcinoma (Ptrend, 1.64E-06). In addition, joint effect between γ-H2AX ratio and smoking was observed: smokers who had high γ-H2AX ratio exhibited the highest risk of esophageal adenocarcinoma (OR = 5.53; 95% CI, 2.71–11.25) compared with never smokers with low γ-H2AX ratio.
Conclusion: Radiation-induced DNA damage assessed by γ-H2AX ratio is associated with an increased risk of esophageal adenocarcinoma.
Impact: γ-H2AX assay is a new and robust method to measure DSB damage in PBLs, which can be used to assess mutagen sensitivity and esophageal adenocarcinoma risk. Cancer Epidemiol Biomarkers Prev; 22(10); 1797–804. ©2013 AACR.
Anticancer Effects of Niclosamide in Human Glioblastoma
Authors: Wieland Anja , Trageser Daniel , Gogolok Sabine , Reinartz Roman , Höfer Heike , Keller Mihaela , Leinhaas Anke , Schelle Ramona , Normann Sabine , Klaas Lil , Waha Andreas , Koch Philipp , Fimmers Rolf , Pietsch Torsten , Yachnis Anthony T. , Pincus David W. , Steindler Dennis A. , Brüstle Oliver , Simon Matthias , Glas Martin , Scheffler Björn 
Published: August 2013

AbstractPurpose: Glioblastoma is a highly malignant, invariably fatal brain tumor for which effective pharmacotherapy remains an unmet medical need.Experimental Design: Screening of a compound library of 160 synthetic and natural toxic substances identified the antihelmintic niclosamide as a previously unrecognized candidate for clinical development. Considering the cellular and interindividual heterogeneity of glioblastoma, a portfolio of short-term expanded primary human glioblastoma cells (pGBM; n = 21), common glioma lines (n = 5), and noncancer human control cells (n = 3) was applied as a discovery platform and for preclinical validation. Pharmacodynamic analysis, study of cell-cycle progression, apoptosis, cell migration, proliferation, and on the frequency of multipotent/self-renewing pGBM cells were conducted in vitro, and orthotopic xenotransplantation was used to confirm anticancer effects in vivo.Results: Niclosamide led to cytostatic, cytotoxic, and antimigratory effects, strongly reduced the frequencies of multipotent/self-renewing cells in vitro, and after exposure significantly diminished the pGBMs' malignant potential in vivo. Mechanism of action analysis revealed that niclosamide simultaneously inhibited intracellular WNT/CTNNB1-, NOTCH-, mTOR-, and NF-κB signaling cascades. Furthermore, combinatorial drug testing established that a heterozygous deletion of the NFKBIA locus in glioblastoma samples could serve as a genomic biomarker for predicting a synergistic activity of niclosamide with temozolomide, the current standard in glioblastoma therapy.Conclusions: Together, our data advocate the use of pGBMs for exploration of compound libraries to reveal unexpected leads, for example, niclosamide that might be suited for further development toward personalized clinical application. Clin Cancer Res; 19(15); 4124–36. ©2013 AACR.
How I treat heterozygous hereditary antithrombin deficiency in pregnancy
Authors: Bramham Kate , Retter Andrew , Robinson Susan E. , Mitchell Michael , Moore Gary W. , Hunt Beverley J. 
Published: August 2013

summaryUntreated hereditary antithrombin deficiency in pregnancy is associated with maternal venous thromboembolism (VTE) and possibly with fetal loss. Thromboprophylaxis during pregnancy is recommended, but dosages remain controversial. Our objective was to perform a retrospective assessment of thrombotic events and pregnancy outcomes in women with hereditary antithrombin deficiency managed according to a standard protocol. Pregnancies in individuals with hereditary antithrombin deficiency were identified from a hospital database. Women with no prior VTE received enoxaparin 40 mg daily until 16 weeks gestation and thereafter 40 mg twice daily. Women with prior VTE received intermediate dose enoxaparin (1 mg/kg) once daily, increased to twice daily at 16 weeks and anti-Xa monitored dosing. Thromboprophylaxis was stopped at initiation of labour or 12 hours prior to caesarean and 50 IU/kg antithrombin concentrate given. Thromboprophylaxis was restarted after delivery. Eighteen pregnancies in 11 women with antithrombin deficiency were identified. Seventeen pregnancies (94%) were successful. Median gestation was 39 weeks (range 30–41) and median birth-weight was 2,995 g (910–4,120 g),but 6/17 infants (35%) were small for gestational age (p=0.01). Estimated blood loss at delivery was median 375 ml (200–600 ml). Four pregnancies were complicated by VTE; one newly presented with a thrombotic event, two patients were not taking thromboprophylaxis and one occurred despite thromboprophylaxis. Two novel mutations(p.Leu317Ser and p.His33GInfsX32) are described. In conclusion, in antithrombin deficiency the use of low-molecular-weight heparin in pregnancy and puerperium with antithrombin concentrate predelivery was associated with successful pregnancy outcome; rates of VTE appear to be lower than previously reported, but remain elevated
Prostate-specific kallikrein-related peptidases and their relation to prostate cancer biology and detection
Authors: Thorek Daniel L. J. , Evans Michael J. , Carlsson Sigrid V. , Ulmert David , Lilja Hans 
Published: August 2013

summaryKallikreins are a family of serine proteases with a range of tissue-specific and essential proteolytic functions. Among the best studied are the prostate tissue-specific KLK2 and KLK3 genes and their secreted protease products, human kallikrein 2, hk2, and prostate-specific antigen (PSA). Members of the so-called classic kallikreins, these highly active trypsin-like serine proteases play established roles in human reproduction. Both hK2 and PSA expression is regulated by the androgen receptor which has a fundamental role in prostate tissue development and progression of disease. This feature, combined with the ability to sensitively detect different forms of these proteins in blood and biopsies, result in a crucially important biomarker for the presence and recurrence of cancer. Emerging evidence has begun to suggest a role for these kallikreins in critical vascular events. This review discusses the established and developing biological roles of hK2 and PSA, as well as the historical and advanced use of their detection to accurately and non-invasively detect and guide treatment of prostatic disease.
Does Rapid Auditory Stimulation Accelerate an Internal Pacemaker? Don’t Bet on It
Authors: Repp Bruno H. , Mendlowitz Hannah B. , Hove Michael J. 
Published: July 2013

Several interesting studies in the literature have demonstrated that a temporal interval coinciding with or following a rapid sequence of auditory stimuli is subjectively lengthened relative to a baseline interval without such rapid auditory stimulation (RAS). It has also been found that an interval preceding RAS is subjectively shortened. These effects have been attributed to acceleration of an internal pacemaker by RAS. The present study used musically trained participants in two experiments, similar to some reported in the literature. In Experiment 1, rapid chromatic scales preceded, followed, or intervened between two empty intervals that had to be compared. In Experiment 2, a series of comparison intervals, each preceded by a series of rapidly repeated tones, had to be compared to a memorized standard interval. Neither experiment yielded any effects of RAS relative to a control condition without RAS. These negative results raise questions about the conditions under which RAS affects interval judgment, and whether pacemaker acceleration is the correct explanation for these effects when they do occur.
Impaired Interval Timing and Spatial–Temporal Integration in Mice Deficient in CHL1, a Gene Associated with Schizophrenia
Authors: Buhusi Mona , Scripa Ioana , Williams Christina L. , Buhusi Catalin V. 
Published: July 2013

Interval timing is crucial for decision-making and motor control and is impaired in many neuropsychiatric disorders, including schizophrenia — a neurodevelopmental disorder with a strong genetic component. Several gene mutations, polymorphisms or rare copy number variants have been associated with schizophrenia. L1 cell adhesion molecules (L1CAMs) are involved in neurodevelopmental processes, and in synaptic function and plasticity in the adult brain. Mice deficient in the Close Homolog to L1 (CHL1) adhesion molecule show alterations of hippocampal and thalamo-cortical neuroanatomy as well as deficits in sensorimotor gating and exploratory behavior. We analyzed interval timing and attentional control of temporal and spatial information in male CHL1 deficient (KO) mice and wild type (WT) controls. In a 20-s peak-interval timing procedure (standard and reversed), KO mice showed a maintained leftward shift of the response function relative to WT, indicative of a deficit in memory encoding/decoding. In trials with 2, 5, or 10-s gaps, KO mice shifted their peak times less than WT controls at longer gap durations, suggesting a decreased (attentional) effect of interruptions. In the spatial–temporal task, KO mice made more working and reference memory errors than controls, suggestive of impaired use of spatial and/or temporal information. When the duration spent on the central platform of the maze was manipulated, WT mice showed fewer spatial errors at the trained duration than at shorter or longer durations, indicative of discrimination based upon spatial–temporal integration. In contrast, performance was similar at all tested durations in KO mice, indicative of control by spatial cues, but not by temporal cues. These results suggest that CHL1 KO mice selectively attend to the more relevant cues of the task, and fail to integrate more complex spatial–temporal information, possibly as a result of reduced memory capacity related to hippocampal impairment, and altered temporal-integration mechanisms possibly due to thalamo-cortical anomalies.
Dopaminergic Modulation of Motor Timing in Healthy Volunteers Differs as a Function of Baseline DA Precursor Availability
Authors: Coull Jennifer T. , Hwang Hye J. , Leyton Marco , Dagher Alain 
Published: July 2013

Although numerous experiments in patients and animals implicate the dopamine (DA) system in timing, there are relatively few studies examining this effect in healthy volunteers. Moreover, the majority of these studies employed tasks of perceptual timing. We therefore investigated the DA modulation of motor timing in healthy volunteers using Acute Phenylalanine/Tyrosine Depletion (APTD), an amino-acid drink that reduces concentrations of the DA precursors tyrosine and phenylalanine. We also examined how APTD’s effects on timing might differ as a function of underlying DA function, as indexed by baseline levels of DA precursors. 18 healthy volunteers performed a Mixed Temporal Reproduction task, in which reproduction of five different sample durations (500 ms–1500 ms) were tested within a single testing block. Reproduction times conformed to Vierordt’s Law, such that the shortest durations were overestimated and the longest ones underestimated. Yet contrary to reported effects in Parkinson’s disease, we found no DA modulation of this ‘migration’ effect in our healthy volunteers. Instead, APTD produced systematic shifts in reproduction time across all durations. However, the direction of the shift differed according to individual differences in baseline levels of DA precursor availability. Specifically, APTD slowed reproduction times in participants with low baseline DA precursor levels whereas it speeded them in participants with high baseline levels. These apparently paradoxical effects can be reconciled in terms of the inverted U-shaped relationship between DA function and cognition. Finally, APTD had no effect on a test of temporal production in which participants were asked to provide spontaneous estimates of a one-second time interval. The differential effect of APTD on the reproduction versus production tasks suggests DA modulates the magnitude of the duration initially encoded into working memory, rather than clock-speed.
Krobia petitella, a new species of cichlid fish from the Berbice River in Guyana (Teleostei: Cichlidae)
Authors: STEELE SARAH E. , LIVERPOOL ELFORD , LÓPEZ-FERNÁNDEZ HERNÁN 
Published: July 2013

Krobia petitella, new species, is described from the Berbice River drainage of northeastern Guyana. It is distinguished from all other described species of Krobia (K. guianensis Regan, K. itanyi Puyo and K. xinguensis Kullander) as well as the closely related ‘Aequidens’ potaroensis and ‘A’. paloemeuensis by tubed scales of the upper lateral line extending caudally into a line bisecting the lateral band blotches posterior to the mid-lateral spot. Krobia petitella n. sp. can be further diagnosed by the anterior lateral band spots lying immediately ventral to the upper lateral line, instead of being separated from the upper lateral line by a complete row of scales in all other species. Additionally, K. petitella n. sp. possesses a unique lateral coloration pattern formed by the combination of six vertical bars and four lateral band spots (vs. K. itanyi 5 bars/3 or 4 spots, K. guianensis 5/5, K. xinguensis 7/6, ‘Aequidens’ potaroensis 6/6, ‘A’. paloemeuensis 5/5). The presence of Krobia petitella n. sp. in reaches of the Berbice River drainage in the Upper Demerara–Berbice region provides a novel locality for the genus in the Guianas and suggests the Berbice River has been isolated from the rest of nearby Guianese basins, particularly the Essequibo and the Corantijn.
Tersilochinae (Hymenoptera: Ichneumonidae) of Costa Rica, part 2. Genera Megalochus gen. nov. and Stethantyx Townes
Authors: KHALAIM ANDREY I. , BROAD GAVIN R. 
Published: July 2013

Two Costa Rican genera, Megalochus gen. nov. and Stethantyx Townes, are revised. These genera comprise a distinctive generic group that we refer to as the Stethantyx genus-group, veins Rs+2r and Rs angled more than 90°, vein 2rs-m and abscissa of M between 2rs-m and 2m-cu not or very weakly thickened, hind wing with vein cu1&cu-a (nervellus) more or less vertical, and prepectal carina with upper end not reaching anterior margin of mesopleuron, continuing above and backwards to the subtegular ridge. Both genera include medium sized to large species with body length 4.0 to 15.0 mm. Megalochus comprises only the type species, M. grandis sp. nov., occurring in Costa Rica, Ecuador and southern Brazil. It is the largest representative of the subfamily, with a body length of 10.5 to 15.0 mm. Megalochus differs from Stethantyx, besides the larger body size, by the slenderer first metasomal segment, which is round in cross-section and lacking glymmae, propodeum and metapleuron with coarse rugae, and shortened antennae with strongly transverse flagellomeres. Stethantyx is the dominant, most species-rich genus in the Costa Rican tersilochine fauna and probably in the Neotropical region. Twenty two species of this genus were discovered in Costa Rica, all are new: S. alajuela sp. nov., S. altamira sp. nov., S. aprica sp. nov., S. cacaoensis sp. nov., S. cartagoa sp. nov., S. cecilia sp. nov., S. curvator sp. nov., S. guanacasteca sp. nov., S. heredia sp. nov., S. limona sp. nov., S. mesoscutator sp. nov., S. niger sp. nov., S. nigrofemorata sp. nov., S. notaulator sp. nov., S. orosia sp. nov., S. osa sp. nov., S. propodeator sp. nov., S. pseudoorosia sp. nov., S. pseudoosa sp. nov., S. puntarenasa sp. nov., S. sanjosea sp. nov. and S. tenoriosa sp. nov. A key for distinguishing the genera Megalochus and Stethantyx, and a key to 22 Costa Rican species of Stethantyx are provided.
A new species of the genus Achaemenothrombium (Acari: Achaemenothrombiidae) from Iran
Authors: SABOORI ALIREZA , WOHLTMANN ANDREAS , HAKIMITABAR MASOUD , SHIRVANI ASGHAR 
Published: August 2013

Achaemenothrombium dariusi Saboori, Wohltmann & Hakimitabar sp. nov. (Acari, Prostigmata: Trombidioidea) is described and illustrated from larvae ectoparasitic on Euxoa fallax (Eversmann) (Lepidoptera: Noctuidae) from Sirch and Cheshmeh Bondar, Kerman province, Iran. It is the third species of this genus, which is recorded only from Iran. The status of this small family is discussed and a key to species of Achaemenothrombium (larvae) is presented.
A Conservative Semi-Lagrangian Discontinuous Galerkin Scheme on the Cubed Sphere
Authors: Guo Wei , Nair Ramachandran D. , Qiu Jing-Mei 
Published: August 2013

Abstract
The discontinuous Galerkin (DG) methods designed for hyperbolic problems arising from a wide range of applications are known to enjoy many computational advantages. DG methods coupled with strong-stability-preserving explicit Runge–Kutta discontinuous Galerkin (RKDG) time discretizations provide a robust numerical approach suitable for geoscience applications including atmospheric modeling. However, a major drawback of the RKDG method is its stringent Courant–Friedrichs–Lewy (CFL) stability restriction associated with explicit time stepping. To address this issue, the authors adopt a dimension-splitting approach where a semi-Lagrangian (SL) time-stepping strategy is combined with the DG method. The resulting SLDG scheme employs a sequence of 1D operations for solving multidimensional transport equations. The SLDG scheme is inherently conservative and has the option to incorporate a local positivity-preserving filter for tracers. A novel feature of the SLDG algorithm is that it can be used for multitracer transport for global models employing spectral-element grids, without using an additional finite-volume grid system. The quality of the proposed method is demonstrated via benchmark tests on Cartesian and cubed-sphere geometry, which employs nonorthogonal, curvilinear coordinates.
The effect of electronic ordering on pre-analytical errors in primary care
Authors: Turner Helen E , Deans Kevin A , Kite Austen , Croal Bernie L 
Published: July 2013

Background Pre-analytical variables are common across all laboratories and can negatively impact on patient care. The aim of this study was to review the impact of electronic requesting in Primary Care on the number of pre-analytical errors seen by the laboratory. Method Error data were reviewed during two six-month periods, pre- and post-implementation of Primary Care electronic requesting. The outcome measures related to: the correct information on the sample tube (patient name, unique patient ID number, date of collection); the correct sample received and the availability of a clinical history. Results There was a marked decrease in the number of pre-analytical errors following the introduction of electronic requesting (2764 pre-implementation vs. 498 post-implementation, P < 0.001). There was an improvement in the quality of information provided with each request in the forms of clinical history, date and time of sample collection. Conclusions The introduction of electronic requesting in Primary Care can reduce the number of pre-analytical errors and can improve the quality of information received with each request.