bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous −1$-1$ hypergeometric orthogonal polynomials
Authors: Pelletier Jonathan , Vinet Luc , Zhedanov Alexei 
Published: July 2024

AbstractThe study of orthogonal polynomials viewed as limits of the ‐orthogonal polynomials is pursued. This paper presents the continuous polynomials part of the analog of the ‐Askey scheme. A compendium of the properties of all the continuous hypergeometric polynomials and their connections is provided.
The Saffman–Taylor problem and several sets of remarkable integral identities
Authors: Fokas A. S. , Kalimeris K. 
Published: July 2024

AbstractThe methodology based on the so‐called global relation, introduced by the first author, has recently led to the derivation of a novel nonlinear integral‐differential equation characterizing the classical problem of the Saffman–Taylor fingers with nonzero surface tension. In the particular case of zero surface tension, this equation is satisfied by the explicit solution obtained by Saffman and Taylor. Here, first, for the case of zero surface tension, we present a new nonlinear integrodifferential equation characterizing the Saffman–Taylor fingers. Then, by using the explicit Saffman–Taylor solution valid for the particular case of zero surface tension, we show that the above equations give rise to sets of remarkable integral trigonometric identities.
Theorizing a denial reaction to coming out: Revising Goffman's stigma through a sexual identity process model
Authors: Patel Sonali 
Published: July 2024

AbstractErving Goffman's seminal theorization of stigma is at the heart of social scientific conceptualizations of identity management. Using data from qualitative interviews with queer South Asian women in Canada, this article proposes revisions of Goffman's Stigma theory. Intervening his supposition of acceptance and hostility as the two possible reactions to stigma revelation, I establish denial as an additional reaction to identity disclosure. A denial reaction has four key characteristics: (1) resistance to queer sexuality, (2) prescriptive enforcement of heterosexuality, (3) refusal to accept lesbian relationships, and (4) avoidance of conversation about queerness. I argue that disclosure to parents does not always translate to outness; rather, it can force the individual back into the closet. I refer to this non‐linear process as the culturally expansive closet. The article presents a sexual identity management process model that accounts for these culturally collectivist experiences. The results are significant for rethinking and affirming non‐Western ways of managing stigmatized identities.
Models for predicting the risk of illness in leprosy contacts in Brazil: Leprosy prediction models in Brazilian contacts
Authors: de Alecrin Edilamar Silva , Martins Maria Auxiliadora Parreiras , de Oliveira Ana Laura Grossi , Lyon Sandra , Lages Ana Thereza Chaves , Reis Ilka Afonso , Pereira Fernando Henrique , Oliveira Dulcinea , Goulart Isabela Maria Bernardes , da Costa Rocha Manoel Otávio 
Published: July 2024

AbstractObjectiveThis study aims to develop and validate predictive models that assess the risk of leprosy development among contacts, contributing to an enhanced understanding of disease occurrence in this population.MethodsA cohort of 600 contacts of people with leprosy treated at the National Reference Center for Leprosy and Health Dermatology at the Federal University of Uberlândia (CREDESH/HC‐UFU) was followed up between 2002 and 2022. The database was divided into two parts: two‐third to construct the disease risk score and one‐third to validate this score. Multivariate logistic regression models were used to construct the disease score.ResultsOf the four models constructed, model 3, which included the variables anti‐phenolic glycolipid I immunoglobulin M positive, absence of Bacillus Calmette‐Guérin vaccine scar and age ≥60 years, was considered the best for identifying a higher risk of illness, with a specificity of 89.2%, a positive predictive value of 60% and an accuracy of 78%.ConclusionsRisk prediction models can contribute to the management of leprosy contacts and the systematisation of contact surveillance protocols.
Correcting mortality estimates among children and youth on antiretroviral therapy in southern Africa: A comparative analysis between a multi‐country tracing study and linkage to a health information exchange
Authors: Nyakato Patience , Schomaker Michael , Boulle Andrew , Euvrard Jonathan , Wood Robin , Eley Brian , Prozesky Hans , Christ Benedikt , Anderegg Nanina , Ayakaka Irene , Rafael Idiovino , Kunzekwenyika Cordelia , Moore Carolyn B. , van Lettow Monique , Chimbetete Cleophas , Mbewe Safari , Ballif Marie , Egger Matthias , Yiannoutsos Constantin T. , Cornell Morna , Davies Mary‐Ann 
Published: July 2024

AbstractObjectivesThe objective of this study is to assess the outcomes of children, adolescents and young adults with HIV reported as lost to follow‐up, correct mortality estimates for children, adolescents and young adults with HIV for unascertained outcomes in those loss to follow‐up (LTFU) based on tracing and linkage data separately using data from the International epidemiology Databases to Evaluate AIDS in Southern Africa.MethodsWe included data from two different populations of children, adolescents and young adults with HIV; (1) clinical data from children, adolescents and young adults with HIV aged ≤24 years from Lesotho, Malawi, Mozambique, Zambia and Zimbabwe; (2) clinical data from children, adolescents and young adults with HIV aged ≤14 years from the Western Cape (WC) in South Africa. Outcomes of patients lost to follow‐up were available from (1) a tracing study and (2) linkage to a health information exchange. For both populations, we compared six methods for correcting mortality estimates for all children, adolescents and young adults with HIV.ResultsWe found substantial variations of mortality estimates among children, adolescents and young adults with HIV reported as lost to follow‐up versus those retained in care. Ascertained mortality was higher among lost and traceable children, adolescents and young adults with HIV and lower among lost and linkable than those retained in care (mortality: 13.4% [traced] vs. 12.6% [retained‐other Southern Africa countries]; 3.4% [linked] vs. 9.4% [retained‐WC]). A high proportion of lost to follow‐up children, adolescents and young adults with HIV had self‐transferred (21.0% and 47.0%) in the traced and linked samples, respectively. The uncorrected method of non‐informative censoring yielded the lowest mortality estimates among all methods for both tracing (6.0%) and linkage (4.0%) approaches at 2 years from ART start. Among corrected methods using ascertained data, multiple imputation, incorporating ascertained data (MI(asc.)) and inverse probability weighting with logistic weights were most robust for the tracing approach. In contrast, for the linkage approach, MI(asc.) was the most robust.ConclusionsOur findings emphasise that lost to follow‐up is non‐ignorable and both tracing and linkage improved outcome ascertainment: tracing identified substantial mortality in those reported as lost to follow‐up, whereas linkage did not identify out‐of‐facility deaths, but showed that a large proportion of those reported as lost to follow‐up were self‐transfers.
Utilizing codon degeneracy in the design of donor DNA for CRISPR/Cas9‐mediated gene editing to streamline the screening process for single amino acid mutations
Authors: Li Xuecheng , Zhang Yongli , Wen Xin , Pan Junmin 
Published: July 2024

SUMMARYChlamydomonas reinhardtii, a unicellular green alga, has been widely used as a model organism for studies of algal, plant and ciliary biology. The generation of targeted amino acid mutations is often necessary, and this can be achieved using CRISPR/Cas9 induced homology‐directed repair to install genomic modifications from exogenous donor DNA. Due to the low gene editing efficiency, the technical challenge lies in identifying the mutant cells. Direct sequencing is not practical, and pre‐screening is required. Here, we report a strategy for generating and screening for amino acid point mutations using the CRISPR/Cas9 gene editing system. The strategy is based on designing donor DNA using codon degeneracy, which enables the design of specific primers to facilitate mutant screening by PCR. An in vitro assembled RNP complex, along with a dsDNA donor and an antibiotic resistance marker, was electroporated into wild‐type cells, followed by PCR screening. To demonstrate this principle, we have generated the E102K mutation in centrin and the K40R mutation in α‐tubulin. The editing efficiencies at the target sites for Centrin, TUA1, TUA2 were 4, 24 and 8% respectively, based on PCR screening. More than 80% of the mutants with the expected size of PCR products were precisely edited, as revealed by DNA sequencing. Subsequently, the precision‐edited mutants were biochemically verified. The introduction of codon degeneracy did not affect the gene expression of centrin and α‐tubulins. Thus, this approach can be used to facilitate the identification of point mutations, especially in genes with low editing rates.
On the Potential of Biomass-Fueled Externally Fired Micro-Gas Turbines in the Energy Transition: Off-Design Performance Analysis
Authors: Bollas Konstantinos , Banihabib Reyhaneh , Assadi Mohsen , Kalfas Anestis 
Published: July 2024

Abstract
The potential of replacing the use of natural gas with biomass gasification syngas through an externally fired micro-gas turbine (EFMGTs) is the main scope of this study. This includes the performance assessment at various off-design and ambient conditions compared to a reference natural-gas-fired Micro-Gas Turbine. The penetration of biomass use in the decentralized combined heat and power (CHP) sector can reduce fossil fuel dependency and contribute to the achievement of the net-zero emissions target. For this purpose, an analytical externally fired thermodynamic model is incorporated and validated with an artificial neural network (ANN) based on a natural-gas-fired micro-gas turbine unit. An operating strategy is proposed to ensure the system's safe operation under any fuel input conditions. The performance between the investigated cases is compared using an exergetic analysis. The main loss contributors that determine each case's performance are the exit losses. The substantial decrease of the latter results in high externally fired part-load efficiency, maximizing 110% of design-point efficiency. System performance has a linear dependency on ambient conditions. The increased flexibility introduced by the proposed operating strategy case facilitates the transition from natural gas to biomass, especially for higher heat-to-power ratio demands. The analysis highlights that the current externally fired configuration lags behind in high electrical demands (&gt;90 kWel). However, this deficiency is diminished in cold ambient temperatures (&lt;0 °C), indicating that the proposed technology is very opportune for these climatic conditions.
A Dynamic Testing Approach for Particulate Erosion–Corrosion for Gas Turbine Coatings
Authors: Stokes Jamesa L. , Presby Michael J. 
Published: July 2024

Abstract
Particle interactions in engines can be complex phenomena leading to degradation of thermal (TBCs) and environmental barrier coatings (EBCs) meant to protect engine components. Ingestion of particles into the engine can lead to recession of coatings due to particle erosion. Similarly, these particles can become molten, adhere to coatings, and result in thermochemical corrosion of coating materials. Erosion testing is often carried out where particles are injected into a gas stream, accelerated within a nozzle, and impinge on samples. Conversely, most molten particle corrosion testing is often done in static furnaces, which does not capture the dynamic nature of deposition. Nevertheless, these damage mechanisms are often tested separately, and no standard exists to test both erosive/corrosive particle interactions with coating materials under relevant turbine operating conditions. Understanding the synergies of particle interactions is crucial in determining operating lifetimes of potential coating materials. Such considerations emphasize the need for realistic approaches in standardizing particle interaction testing in combustion environments. This study outlines efforts at NASA Glenn's Erosion Burner Rig Facility in improving dynamic erosion/corrosion testing methods by assessing the durability of state-of-the-art (SOA) TBC 7 wt % yttria-stabilized zirconia (7YSZ) as a function of particle deposition rate, burner temperature, and particle size. Calibration data to determine particle deposition rate will be presented, and mass and optical profilometry measurements were utilized to estimate mass/volume loss versus deposition per increment of particulate used. Electron microscopy analyses were then carried out to assess coating damage after testing.
Local tumour control and patient survival after ruthenium-106 brachytherapy for small choroidal melanoma
Authors: Gallo Beatrice , Hussain Rohan , Al-Jamal Ranaa , Khalid Hagar , Stoker Ian , Hay Gordon , Arora Amit K , Szlosarek Peter W , Sagoo Mandeep S 
Published: July 2024

Aim
To report local tumour control, metastasis and survival rates of patients with small choroidal melanoma (CM) after treatment with ruthenium-106 (Ru-106) plaque brachytherapy.

Methods
Retrospective case series of 353 consecutive eyes with small CM (thickness ≤2.5 mm and largest basal diameter ≤16 mm) treated with Ru-106 brachytherapy at the London Ocular Oncology Service, between October 2004 and May 2019.

Results
The final cohort included 310 eyes and tumour recurrence was observed in 52 (17%) eyes. Ocular retention rate was 96%. Metastatic disease and tumour-related death occurred in 18 (5.8%) and 12 (3.9%) patients, respectively. Metastases were diagnosed after a median of 54 (54±35; range 3.6–118) months from initial treatment. Kaplan-Meier estimates for tumour recurrence, melanoma-related metastases and survival were 17% (95% CI 13.3% to 22.9%), 4.8% (95% CI 2.6% to 8.5%) and 98% (95% CI 94.4% to 99.1%) at 5 years and 26% (95% CI 18.3% to 35.3%), 16% (95% CI 8.7% to 27.7%) and 92% (95% CI 84.5% to 95.7%) at 10 years, respectively. On multivariable analysis, factors predictive for tumour recurrence included juxtapapillary location, larger plaque and final tumour thickness, and for metastasis exudative retinal detachment.

Conclusion
Small CMs treated with Ru-106 brachytherapy show recurrence and death rates of 17% and 2% at 5 years and 26% and 8% at 10 years. As small CMs have better prognosis than large tumours, early treatment is the key for better survival outcomes.
Navigating process evaluation in co-creation: a Health CASCADE scoping review of used frameworks and assessed components
Authors: Longworth Giuliana Raffaella , de Boer Janneke , Goh Kunshan , Agnello Danielle Marie , McCaffrey Lauren , Zapata Restrepo Jorge Raul , An Qingfan , Chastin Sebastien , Davis Aaron , Altenburg Teatske , Verloigne Maite , Giné-Garriga Maria 
Published: July 2024

BackgroundCo-creation is seen as a way to ensure all relevant needs and perspectives are included and to increase its potential for beneficial effects and uptake process evaluation is crucial. However, existing process evaluation frameworks have been built on practices characterised by top-down developed and implemented interventions and may be limited in capturing essential elements of co-creation. This study aims to provide a review of studies planning and/or conducting a process evaluation of public health interventions adopting a co-creation approach and aims to derive assessed process evaluation components, used frameworks and insights into formative and/or participatory evaluation.MethodsWe searched for studies on Scopus and the Health CASCADE Co-Creation Database. Co-authors performed a concept-mapping exercise to create a set of overarching dimensions for clustering the identified process evaluation components.Results54 studies were included. Conceptualisation of process evaluation included in studies concerned intervention implementation, outcome evaluation, mechanisms of impact, context and the co-creation process. 22 studies (40%) referenced ten existing process evaluation or evaluation frameworks and most referenced were the frameworks developed by Mooreet al(14%), Saunderset al(5%), Steckler and Linnan (5%) and Nielsen and Randall (5%).38 process evaluation components were identified, with a focus on participation (48%), context (40%), the experience of co-creators (29%), impact (29%), satisfaction (25%) and fidelity (24%).13 studies (24%) conducted formative evaluation, 37 (68%) conducted summative evaluation and 2 studies (3%) conducted participatory evaluation.ConclusionThe broad spectrum of process evaluation components addressed in co-creation studies, covering both the evaluation of the co-creation process and the intervention implementation, highlights the need for a process evaluation tailored to co-creation studies. This work provides an overview of process evaluation components, clustered in dimensions and reflections which researchers and practitioners can use to plan a process evaluation of a co-creation process and intervention.
Exploring early discontinuation of mental health outpatient treatment: language, demographics and clinical characteristics among migrant populations in Japan
Authors: Tsoh Janice Y , Takubo Youji , Fukui Eriko , Suzuki Ayaka , Iwai Momoko , Saito Hisaaki , Tsujino Naohisa , Uchino Takashi , Katagiri Naoyuki , Nemoto Takahiro 
Published: July 2024

BackgroundThe fast-growing migrant population in Japan and globally poses challenges in mental healthcare, yet research addressing migrants’ mental health treatment engagement remains limited.ObjectiveThis study examined language proficiency, demographic and clinical characteristics as predictors of early treatment discontinuation among migrants.MethodsElectronic health record data from 196 adult migrants, identified from 14 511 patients who received mental health outpatient treatment during 2016 and 2019 at three central hospitals in the Tokyo-Yokohama metropolitan region of Japan, were used. We conducted multivariable regression models to identify predictors of early discontinuation within 3 months.FindingsThe study cohort (66% women, age range: 18–90 years, from 29 countries or regions) included 23% non-Japanese speakers. Japanese and non-Japanese speakers had similar discontinuation rates (26% vs 22%). Multivariable models revealed younger age (OR=0.97; 95% CI: 0.95, 0.99; p=0.016) and those with a primary diagnosis other than a schizophrenia spectrum disorder (OR=3.99; 95% CI: 1.36, 11.77; p=0.012) or a neurotic, stress-related and somatoform disorder (OR=2.79; 95% CI: 1.14, 6.84; p=0.025) had higher odds of early discontinuation. These effects were more pronounced among the Japanese speakers with significant language-by-age and language-by-diagnoses interactions.ConclusionYounger age and having a primary diagnosis other than a schizophrenia spectrum disorder or a neurotic, stress-related and somatoform disorder increased vulnerability for discontinuing mental health treatment early in Japanese-speaking migrants but not for migrants with limited Japanese proficiency.Clinical implicationsUnderstanding language needs within a context of mental health treatment should go beyond assumed or observed fluency. Unmet language needs might increase vulnerability for treatment disengagement among migrants. Targeted clinical efforts are crucial for enhancing early treatment engagement and informing health practices in Japan and countries with growing migrant populations.
Developing a customised set of evidence-based quality indicators for measuring workplace violence towards healthcare workers: a modified Delphi method
Authors: Sethi Rickinder , Lyver Brendan , Gorla Jaswanth , Singh Brendan , Hanagan Trevor , Haines Jennifer , Toppings Marc , Schulz-Quach Christian 
Published: July 2024

BackgroundWorkplace violence (WPV) is a complex global challenge in healthcare that can only be addressed through a quality improvement initiative composed of a complex intervention. However, multiple WPV-specific quality indicators are required to effectively monitor WPV and demonstrate an intervention’s impact. This study aims to determine a set of quality indicators capable of effectively monitoring WPV in healthcare.MethodsThis study used a modified Delphi process to systematically arrive at an expert consensus on relevant WPV quality indicators at a large, multisite academic health science centre in Toronto, Canada. The expert panel consisted of 30 stakeholders from the University Health Network (UHN) and its affiliates. Relevant literature-based quality indicators which had been identified through a rapid review were categorised according to the Donabedian model and presented to experts for two consecutive Delphi rounds.Results87 distinct quality indicators identified through the rapid review process were assessed by our expert panel. The surveys received an average response rate of 83.1% in the first round and 96.7% in the second round. From the initial set of 87 quality indicators, our expert panel arrived at a consensus on 17 indicators including 7 structure, 6 process and 4 outcome indicators. A WPV dashboard was created to provide real-time data on each of these indicators.ConclusionsUsing a modified Delphi methodology, a set of quality indicators validated by expert opinion was identified measuring WPV specific to UHN. The indicators identified in this study were found to be operationalisable at UHN and will provide longitudinal quality monitoring. They will inform data visualisation and dissemination tools which will impact organisational decision-making in real time.
Cold versus hot snare endoscopic mucosal resection for large (≥15 mm) flat non-pedunculated colorectal polyps: a randomised controlled trial
Authors: O’Sullivan Timothy , Cronin Oliver , van Hattem W Arnout , Mandarino Francesco Vito , Gauci Julia L , Kerrison Clarence , Whitfield Anthony , Gupta Sunil , Lee Eric , Williams Stephen J , Burgess Nicholas , Bourke Michael J 
Published: July 2024

Background and aims
Conventional hot snare endoscopic mucosal resection (H-EMR) is effective for the management of large (≥20 mm) non-pedunculated colon polyps (LNPCPs) however, electrocautery-related complications may incur significant morbidity. With a superior safety profile, cold snare EMR (C-EMR) of LNPCPs is an attractive alternative however evidence is lacking. We conducted a randomised trial to compare the efficacy and safety of C-EMR to H-EMR.

Methods
Flat, 15–50 mm adenomatous LNPCPs were prospectively enrolled and randomly assigned to C-EMR or H-EMR with margin thermal ablation at a single tertiary centre. The primary outcome was endoscopically visible and/or histologically confirmed recurrence at 6 months surveillance colonoscopy. Secondary outcomes were clinically significant post-EMR bleeding (CSPEB), delayed perforation and technical success.

Results
177 LNPCPs in 177 patients were randomised to C-EMR arm (n=87) or H-EMR (n=90). Treatment groups were equivalent for technical success 86/87 (98.9%) C-EMR versus H-EMR 90/90 (100%); p=0.31. Recurrence was significantly greater in C-EMR (16/87, 18.4% vs 1/90, 1.1%; relative risk (RR) 16.6, 95% CI 2.24 to 122; p<0.001).
Delayed perforation (1/90 (1.1%) vs 0; p=0.32) only occurred in the H-EMR group. CSPEB was significantly greater in the H-EMR arm (7/90 (7.8%) vs 1/87 (1.1%); RR 6.77, 95% CI 0.85 to 53.9; p=0.034).

Conclusion
Compared with H-EMR, C-EMR for flat, adenomatous LNPCPs, demonstrates superior safety with equivalent technical success. However, endoscopic recurrence is significantly greater for cold snare resection and is currently a limitation of the technique.

Trial registration number

NCT04138030