bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of kynurenic acid on enzymatic activity of the DNA base excision repair pathway in specific areas of the sheep brain
Authors: Młotkowska Patrycja , Misztal Tomasz , Kowalczyk Paweł , Marciniak Elżbieta 
Published: July 2024

AbstractRelatively low levels of antioxidant enzymes coupled with high oxygen metabolism result in the formation of numerous oxidative DNA damages in the tissues of the central nervous system. Recently, kynurenic acid (KYNA), knowns for its neuroprotective properties, has gained increasing attention in this context. Therefore, our hypothesis assumed that increased KYNA levels in the brain would positively influence mRNA expression of selected enzymes of the base excision repair pathway as well as enhance their efficiency in excising damaged nucleobases in specific areas of the sheep brain. The study was conducted on adult anestrous sheep (n = 18), in which two different doses of KYNA (20 and 100 μg/day) were infused into the third brain ventricle for three days. Molecular and biochemical analysis included the hypothalamus (preoptic and mediol-basal areas), hippocampus (CA3 field) and amygdala (central amygdaloid nucleus), dissected from the brain of sheep euthanized immediately after the last infusion. The results revealed a significant increase P < 0.001) in the relative mRNA abundance of N-methylpurine DNA glycosylase (MPG) following administration of both dose of KYNA across all examined tissues. The transcription of thymine-DNA glycosylase (TDG) increased significantly (P < 0.001) in all tissues in response to the lower KYNA dose compared to the control group. Moreover, 8-oxoguanine (8-oxoG) DNA glycosylase (OGG1) mRNA levels were also higher in both animal groups (P < 0.001). In addition, in the hypothalamus, hippocampus and amygdala, AP endonuclease 1 (APE1) mRNA expression increased under both doses of KYNA. Moreover, the both dose of KYNA significantly stimulated the efficiency of 8-oxoG excision in hypothalamus and amygdala (P < 0.05–0.001). The lower and higher doses of KYNA significantly influenced the effectiveness of εA and εC in all structures (P < 0.01–0.001). In conclusion, the favorable effect of KYNA in the brain may include the protection of genetic material in nerve and glial cells by stimulating the expression and efficiency of BER pathway enzymes.
NLRC5 promotes tumorigenesis by regulating the PI3K/AKT signaling pathway in cervical cancer
Authors: Ling Lin , Chen Jiahua , Zhan Lei , Fu Juanjuan , He Runhua , Wang Wenyan , Wei Bing , Ma Xiaofeng , Cao Yunxia 
Published: July 2024

AbstractCervical cancer (CC) is the fourth most common cancer among women worldwide. NLR Family CARD Domain Containing 5 (NLRC5) plays an important role in tumorigenesis. However, its effect and mechanism in CC remains unclear. In this study, we aimed to investigate the function of NLRC5 in CC. NLRC5 was found to be down-regulated in CC tissues compared with normal cervical tissues. However, patients with higher NLRC5 expression had better prognosis, patients with higher age, HPV infection, lymph node metastasis, recurrence and histological grade had worse prognosis. Univariate and multivariate analyses showed NLRC5 to be a potential prognostic indicator for CC. Pearson correlation analysis showed that NLRC5 might exert its function in CC through autophagy related proteins, especially LC3. In vitro experiments demonstrated that NLRC5 inhibited LC3 levels and promoted the proliferation, migration, and invasion of CC cells by activating the PI3K/AKT signaling pathway. Treatment with LY294002 reversed the above phenotype. Taken together, our finding suggested that NLRC5 would participate in cervical tumorigenesis and progression by regulating PI3K/AKT signaling pathway. In addition, NLRC5 and LC3 combined as possible predictors in CC.
IRF5 suppresses metastasis through the regulation of tumor-derived extracellular vesicles and pre-metastatic niche formation
Authors: Roberts Bailey K. , Li Dan Iris , Somerville Carter , Matta Bharati , Jha Vaishali , Steinke Adison , Brune Zarina , Blanc Lionel , Soffer Samuel Z. , Barnes Betsy J. 
Published: July 2024

AbstractMetastasis is driven by extensive cooperation between a tumor and its microenvironment, resulting in the adaptation of molecular mechanisms that evade the immune system and enable pre-metastatic niche (PMN) formation. Little is known of the tumor-intrinsic factors that regulate these mechanisms. Here we show that expression of the transcription factor interferon regulatory factor 5 (IRF5) in osteosarcoma (OS) and breast carcinoma (BC) clinically correlates with prolonged survival and decreased secretion of tumor-derived extracellular vesicles (t-dEVs). Conversely, loss of intra-tumoral IRF5 establishes a PMN that supports metastasis. Mechanistically, IRF5-positive tumor cells retain IRF5 transcripts within t-dEVs that contribute to altered composition, secretion, and trafficking of t-dEVs to sites of metastasis. Upon whole-body pre-conditioning with t-dEVs from IRF5-high or -low OS and BC cells, we found increased lung metastatic colonization that replicated findings from orthotopically implanted cancer cells. Collectively, our findings uncover a new role for IRF5 in cancer metastasis through its regulation of t-dEV programming of the PMN.
Effects of the ligand linkers on stability of mixed-valence Cu(I)Cu(II) and catalytic aerobic alcohol oxidation activity
Authors: Jehdaramarn Attawit , Chantarojsiri Teera , Worakul Thanapat , Surawatanawong Panida , Chainok Kittipong , Sangtrirutnugul Preeyanuch 
Published: July 2024

AbstractWe synthesized a class of ligands that feature single (L1) and dual amine-bis(triazole) chelates (L2 with a 1,3-phenylene linker and L3 with a 1,5-naphthalene linker). Our findings which were derived from UV–Vis titrations, crystal structure analysis of relevant copper complexes, and DFT calculations indicate the formation of both mononuclear CuBr(L1) and dinuclear (μ-Ln)(CuBr)2 (Ln = L2 and L3) complexes. The catalytic activities of CuBr/Ln, in combination with TEMPO (2,2,6,6-tetramethylpiperidin-1-yl)oxyl) co-catalyst and NMI (N-methylimidazole) for aerobic alcohol oxidation, reveal the following activity trend: CuBr/L3 > CuBr/L2 > CuBr/L1. Furthermore, electrochemical data from in-situ generated CuBr complexes suggest that the higher catalytic performance of CuBr/L3 is attributed to the presence of less stable mixed-valence and more reducible Cu(I)-L3-Cu(II) species compared to Cu(I)-L2-Cu(II). This difference is a result of weaker σ interactions between Cu–Namine, larger bridging π systems, and a longer Cu···Cu distance in the presence of L3. Additionally, the catalyst system, CuBr/L3/TEMPO/NMI, efficiently promotes the aerobic oxidation of benzyl alcohol to benzaldehyde at room temperature in CH3CN with a high turnover frequency (TOF) of 38 h−1 at 1 h.
Establishing resilience-targeted prediction models of rainfall for transportation infrastructures for three demonstration regions in China
Authors: Zeng Wen , Sun Xiaodan , Xing Hongping , Liu Yu , Liu Lu 
Published: July 2024

AbstractRainstorm is one of the global meteorological disasters that threaten the safety of transportation infrastructure and the connectivity of transportation system. Aiming to support the resilience assessment of transportation infrastructure in three representative regions: Sichuan–Chongqing, Yangtze River Delta, and Beijing-Tianjin-Hebei-Shandong, rainfall data over 40 years in the three regions are collected, and the temporal distribution of rainfall are analyzed. Prediction equations of rainfall are established. For the purpose of this, the probabilistic density function (PDF) is assigned to the rainfall by fitting the frequency distribution histogram. Using the assigned PDF, the rainfall data are transformed into standard normal space where regression of prediction equations is performed and the prediction accuracy is tested. The results show that: (1) The frequency of rainfall in the three regions follows a lognormal distribution based on which the prediction equations of rainfall can be established in standard normal space. The error of regression shows no remarkable dependence on self-variables, and the significance analysis indicates that the equations proposed in this paper are plausible for predicting rainfalls for the three regions. (2) The Yangtze River Delta region has a higher risk of rainstorm disaster compared to the other two regions according to the frequency of rainfall and the return period of precipitation concentration. (3) Over the period of 1980–2021, the Sichuan–Chongqing region witnessed an increase in yearly rainfall but a decrease in rainstorm disasters, whereas the other two regions experienced a consistent rise in both metrics.
Control over self and others’ face: exploitation and exploration
Authors: Wen Wen , Mei Jie , Aktas Hakan , Chang Acer Yu-Chan , Suzuishi Yosuke , Kasahara Shunichi 
Published: July 2024

AbstractThe face serves as a crucial cue for self-identification, while the sense of agency plays a significant role in determining our influence through actions in the environment. The current study investigates how self-identification through facial recognition may influence the perception of control via motion. We propose that self-identification might engender a belief in having control over one’s own face, leading to a more acute detection and greater emphasis on discrepancies between their actions and the sensory feedback in control judgments. We refer to the condition governed by the belief in having control as the exploitation mode. Conversely, when manipulating another individual’s face, the belief in personal control is absent. In such cases, individuals are likely to rely on the regularity between actions and sensory input for control judgments, exhibiting behaviors that are exploratory in nature to glean such information. This condition is termed the explorative mode. The study utilized a face-motion mixing paradigm, employing a deep generative model to enable participants to interact with either their own or another person’s face through facial and head movements. During the experiment, participants observed either their own face or someone else’s face (self-face vs. other-face) on the screen. The motion of the face was driven either purely by their own facial and head motion or by an average of the participant’s and the experimenter’s motion (full control vs. partial control). The results showed that participants reported a higher sense of agency over the other-face than the self-face, while their self-identification rating was significantly higher for the self-face. More importantly, controlling someone else’s face resulted in more movement diversity than controlling one’s own face. These findings support our exploration–exploitation theory: When participants had a strong belief in control triggered by the self-face, they became highly sensitive to any sensorimotor prediction errors, leading to a lower sense of agency. In contrast, when the belief of control was absent, the exploration mode triggered more explorative behaviors, allowing participants to efficiently gather information to establish a sense of agency.
Dynamics of confined water inside carbon nanotubes based on studying tetrahedral order parameters
Authors: Srivastava Amit , Abedrabbo Sufian , Hassan Jamal , Homouz Dirar 
Published: July 2024

AbstractWater dynamics inside hydrophobic confinement, such as carbon nanotubes (CNTs), has garnered significant attention, focusing on water diffusion. However, a crucial aspect remains unexplored - the influence of confinement size on water ordering and intrinsic hydrogen bond dynamics. To address this gap, we conducted extensive molecular dynamics simulations to investigate local ordering and intrinsic hydrogen bond dynamics of water molecules within CNTs of various sizes (length:20 nm, diameters: 1.0 nm to 5.0 nm) over a wide range of temperatures (260K, 280K, 300K, and 320K). A striking observation emerged: in smaller CNTs, water molecules adopt an icy structure near tube walls while maintaining liquid state towards the center. Notably, water behavior within a 2.0 nm CNT stands out as an anomaly, distinct from other CNT sizes considered in this study. This anomaly was explained through the formation of water layers inside CNTs. The hydrogen bond correlation function of water within CNTs decayed more slowly than bulk water, with an increasing rate as CNT diameter increased. In smaller CNTs, water molecules hold onto their hydrogen bond longer than larger ones. Interestingly, in larger CNTs, the innermost layer’s hydrogen bond lasts a shorter time compared to the other layers, and this changes with temperature.
Influence of thickness and strength on plastic instability in tailored steel structures
Authors: Lu Rihuan , Chen Shoudong , Wang Xiaogong , Li Meihui , Zhang Sijia , Wang Sai , Hu Xianlei , Chen Jingqi , Huang Huagui , Liu Xianghua 
Published: July 2024

AbstractA mathematical model was intricately devised to explore the influence of continuous variations in thickness and mechanical properties on the performance of tailor rolled blanks (TRB) and tailor rolled tubes (TRT). Through the integration of analytical and numerical techniques, it was discerned that these variations play a pivotal role in modulating stress distribution and strain localization, thereby inducing a spectrum of plastic instability behaviors within the structures. The introduction of an ‘equivalent strength’ metric as a novel means to quantify structural performance shed light on strategic material distribution to enhance durability and mechanical efficiency. Moreover, the insights garnered from this research deepen the understanding of the mechanical responses of tailor-rolled constructs under varying loads, offering valuable perspectives for the development and fabrication of engineered materials with bespoke properties. This study not only contributes to bridging a knowledge gap in the realm of tailored material engineering but also fosters the advancement of design methodologies in the construction of high-performance engineered structures.
Increased risks of retinal vascular occlusion in patients with migraine and the protective effects of migraine treatment: a population-based retrospective cohort study
Authors: Ho Kuan-Yun , Lin Chia-Der , Hsu Tzu-Ju , Huang Yu-Han , Tsai Fuu-Jen , Liang Chiao-Ying 
Published: July 2024

AbstractAssociations between migraine and retinal vascular occlusion have been reported, but there is no large-scale and comprehensive study. Therefore, we aimed to determine risks of retinal vascular occlusion in patients with migraine. Using the Taiwan National Health Insurance Research Database from 2009 to 2020, we enrolled 628,760 patients with migraine and 628,760 matched individuals without migraine. Study outcomes were diagnoses of retinal vascular occlusion, including retinal artery occlusion (RAO) and retinal vein occlusion (RVO). Adjusted hazard ratio (aHR) of retinal vascular occlusion related to migraine was estimated. The cumulative incidences of subsequent retinal vascular occlusion, RAO, and RVO were significantly higher in migraine patients compared with controls (0.31% vs. 0.21%; 0.09% vs. 0.05%; 0.22% vs. 0.17%; all p < 0.001). The hazards of retinal vascular occlusion, RAO, and RVO were significantly greater in the migraine group (aHR, 1.69 [95% CI, 1.57, 1.83], 2.13 [95% CI, 1.84, 2.48] and 1.53 [95% CI, 1.40, 1.68], respectively). Risks of retinal vascular occlusion were significantly higher in migraine both with aura (MA) and without aura (MO) (aHR, 1.77 [95% CI, 1.58, 1.98], and 1.92 [95% CI, 1.64, 2.25]). Among patients with migraine, nonsteroidal anti-inflammatory drugs, propranolol, and flunarizine significantly reduce their risks of retinal vascular occlusion (aHR, 0.19 [95% CI, 0.16, 0.22], 0.73 [95% CI, 0.62, 0.86], 0.84 [95% CI, 0.76, 0.93]). Migraine, MA and MO are independently associated with higher risks of retinal vascular occlusion, RAO, and RVO.
Study on adsorption of kaolinite and gold thiosulfate
Authors: Chen Zhonghang , Li Pengcheng , Wang Qianqian , Dai Shujuan 
Published: July 2024

AbstractThe adsorption behavior of gold thiosulfate ions on the surface of kaolinite was studied using a combination of experimental research and quantum chemical calculations. Under the condition of a stirring time of 30 min, a stirring speed of 500 r·min−1, and a mass ratio of 30% kaolinite in the slurry, when the initial gold concentration of 56.50 mg·L−1,the adsorption rate of gold-thiosulfate ions from a kaolinite-containing solution was 7.44%. The results of Fourier transform infrared spectroscopy (FTIR) and energy dispersive spectroscopy (EDS) showed that the physical and chemical adsorption of kaolinite and gold thiosulfate occurred in solution. Quantum chemical calculations were performed using the CASTEP module in Materials Studio. The adsorption energy of gold thiosulfate on the surface of kaolinite (001) was calculated as − 438.01 kJ·mol−1.The calculated H76–O289 distance was 1.615 Å. Mulliken Charge population analysis and bond population analysis showed that gold thiosulfate ions form relatively stable bonds on the kaolinite surface (001). In the process of thiosulfate immersion, part of gold is adsorbed by kaolinite, which affects the extraction of gold. These results indicate that during the leaching process of gold thiosulfate, kaolinite has the ability to "catch" gold, which affects the leaching efficiency.
A three-dimensional quantitative assessment on bony growth and symmetrical recovery of mandible after decompression for unicystic ameloblastoma
Authors: Bao Tingwei , Yu Di , Zheng Jiaqi , Zhu Wenyuan , Wei Dong , Wang Huiming 
Published: July 2024

AbstractUnicystic ameloblastoma (UAM) of the jaw can be effectively reduced in volume through decompression, which promotes bone regeneration and restores jaw symmetry. This study quantitatively evaluated changes in mandible volume and symmetry following decompression of mandibular UAM. This study included 17 patients who underwent surgical decompression followed by second-stage curettage for mandibular UAM. Preoperative and postoperative three-dimensional computed tomography (CT) images were collected. Bone volume and the area of cortical perforation were measured to assess bone growth during decompression. Mandibular volumetric symmetry was analyzed by calculating the volumetric ratio of the two sides of the mandible. Twelve pairs of landmarks were identified on the surface of the lesion regions, and their coordinates were used to calculate the mean asymmetry index (AI) of the mandible. Paired t-tests and the Mann–Whitney U test were used for statistical analysis, with p < 0.05 considered indicative of statistical significance. The mean duration of decompression was 9.41 ± 3.28 months. The mean bone volume increased by 8.07 ± 2.41%, and cortical perforation recovery was 71.97 ± 14.99%. The volumetric symmetry of the mandible improved significantly (p < 0.05), and a statistically significant decrease in AI was observed (p < 0.05). In conclusion, UAM decompression enhances bone growth and symmetry recovery of the mandible. The present evaluation technique is clinically useful for quantitatively assessing mandibular asymmetry.
Elevated pulse pressure preceded incident chronic kidney disease in the general older population in Sweden
Authors: Månsson Tomas , Rosso Aldana , Ellström Katarina , Elmståhl Sölve 
Published: July 2024

AbstractArterial stiffness (AS) and chronic kidney disease (CKD) are common in the older population. AS results in increased pulsatile pressure, elevated pulse pressure (PP), and is linked to hypertension. PP is a surrogate for AS. The kidney has low vascular resistance mechanisms, presumably making it vulnerable to the increased pulsatile pressure and hypertension associated with AS. The aims of this study were to investigate the impact of PP elevation on incident CKD (glomerular filtration rate < 60 ml/min/1.73 m2) and all-cause mortality. The data was collected from the general population cohort study “Good Aging in Skåne”. Cox proportional hazard regression models adjusted for age, sex, diabetes, and smoking habits were used to investigate the impact of three levels of PP elevation on incident CKD (n = 2693) and all-cause mortality (n = 5253). For PP < 60 mmHg, the median survival time was 18.7 years (event incident CKD) and first quartile survival time (event all-cause mortality) 15.4 years. Elevated PP ≥ 80 mmHg was associated with incident CKD (hazard ratio 1.59, CI 1.28–1.97), but not all-cause mortality. Our results suggest that a finding of PP ≥ 80 mmHg in older age should raise concern of kidney function.
Design of dual mode antenna using CMA and broadband dual-polarized antenna for 5G networks
Authors: Sathishkumar N. , Palanisamy SatheeshKumar , Natarajan Rajesh , Ouahada Khmaies , Hamam Habib 
Published: July 2024

AbstractThis article proposes a dual mode dual-polarized antenna configuration for IRNSS and fifth generation (5G) applications, operating at a frequency of 3.5 GHz based on characteristic mode analysis (CMA), and aims to provide broadband dual-polarized functionality. The original design of the antenna is a traditional patch antenna, and its dual-polarized features are determined using characteristic mode analysis. The full-wave method is used to stimulate both orthogonal modes using a 50 Ω coaxial input line at 3.5 GHz. In this design, the circular patch has been extended into an elliptical patch through a process of mode separation. The circular patch exhibits resonance at a frequency of 2.5 GHz, whereas the extended elliptical radiator demonstrates two resonance modes at 2.5 GHz and 3.5 GHz. The operational mechanism is elucidated by modal analysis and characteristic angle. This antenna operates on two different frequencies at the 2.5 GHz IRNSS band with horizontal polarization and the 3.5 GHz 5G service with vertical polarization. The maximum gain achieved with these frequency ranges is 5.31 dBi and 4.72 dBi, respectively. A ring resonator is chosen to improve the axial ratio and impedance bandwidth of the suggested prototype. The antenna's ground plane is shaped like a rectangle and features a V-shaped slot in the radiating patch. The antenna's physical footprint is 50 mm × 50 mm × 1.6 mm and an FR4 dielectric substrate serves as its foundation. Through its interaction with a PIN diode, the diode modifies the polarization of the antenna. The antenna functions as a right-handed circular polarization (RHCP), when the diode is operational. The bandwidth from 4.3 to 7.5 GHz is covered. On the other hand, it generates linear polarization (LP) between 4.2 and 5.3 GHz. The experimental antenna is evaluated and examined for its performance characteristics. The simulations are carried out utilizing the CST simulator. A prototype antenna has been manufactured and its performance has been validated against simulated findings.