bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sarcoidosis in children: HRCT findings and correlation with pulmonary function tests
Authors: Sileo C. , Epaud R. , Mahloul M. , Beydon N. , Elia D. , Clement A. , Pointe H. Ducou Le 
Published: December 2013

SummaryRationaleHigh‐resolution computed tomography (HRCT) plays an important role in the diagnosis and staging of pulmonary sarcoidosis, but implies radiation exposure. In this light, we aimed to describe HRCT findings as well as their relationship with pulmonary function tests (PFT) in children with pulmonary sarcoidosis.MethodsIn a retrospective study, 18 pediatric patients with sarcoidosis, including 12 with pulmonary abnormalities (PA group) and 6 without pulmonary abnormalities (APA group) were followed over a 16‐year period. Relationships between HRCT scores and PFT were studied by non‐parametric Spearman's test at diagnosis and by restricted maximum likelihood (REML) analysis during follow‐up.ResultsForty‐three HRCT were scored. Twelve patients showed abnormal HRCT findings at diagnosis with multiple nodules or micronodules, while ground‐glass opacities were seen in 11 patients. Ten patients exhibited pleural thickening or thickening of the fissure and 6 had interlobular septal thickening at diagnosis. No correlation between HRCT and forced vital capacity (FVC), forced expiratory volume in 1 sec (FEV1), forced expiratory flow during the mid‐half of the FVC (FEF25–75) and specific dynamical compliance (SpecCLdyn) was found at diagnosis. However, linear mixed models showed that changes in total HRCT scores over time were significantly associated with SpecCLdyn, FVC, and FEV1 modifications.ConclusionRadiologic findings in children with pulmonary sarcoidosis were similar to those in adults. HRCT and PFT are both essential investigations at diagnosis; however, the correlation between HRCT pulmonary parenchymal findings and PFT over time suggests the possibility of reducing the number of HRCT during follow‐up to decrease unnecessary radiation exposure. Pediatr Pulmonol. 2014; 49:1223–1233. © 2013 Wiley Periodicals, Inc.
The Otago Exercise Program Performed as Group Training Versus Home Training in Fall‐prone Older People: A Randomized Controlled Trial
Authors: Kyrdalen Ingebjørg L. , Moen Kjersti , Røysland Anne Sofie , Helbostad Jorunn L. 
Published: December 2013

AbstractBackground and PurposeExercise programs targeting muscle strength and balance can reduce falls. The study aimed to compare the Otago Exercise Program (OEP), originally designed as supervised home training (HT), with the same programme performed as GT, on functional balance and muscle strength, mobility, fall efficacy and self‐reported health.MethodsA single‐blind randomized controlled trial with assessments at baseline (T1), following the 12‐week intervention (T2), and 3 months following intervention (T3), was performed. 125 people, mean age 82.5 (SD = 5.7) years, 73% women, referred to a Falls Outpatient Clinic, participated. 74% had fallen, and 37% had a fall‐related hospital stay during the previous year. OEP supervised by physiotherapists was performed as GT twice weekly or as HT three times a week, for 12 weeks. Total exercise time was comparable between groups. The primary outcome was the Berg Balance Scale assessed at T2.ResultsFrom T1–T2, Berg Balance Scale improved significantly more in the GT group than in the HT group (mean group difference in change of 3.2 points, 95%CI = 0.7–5.8, p = 0.014). Of the secondary outcomes, the 30‐second sit‐to‐stand test (p = 0.004), and physical health measured by the Short Form‐36 (p = 0.004), improved significantly more for the GT group. Change in mobility measured by the Timed Up and Go test, mental health by the Short Form‐36, and fall efficacy by the Fall Efficacy Scale International did not differ between groups. The 30‐second sit‐to‐stand test and the Timed Up and Go, but not the Berg Balance Scale, was still better in the GT group at T3.DiscussionIn fall‐prone home‐dwelling older people, the OEP performed as GT is more effective for improving functional balance, muscle strength and physical health, but not fall efficacy and mental health than when performed as HT. The OEP provided as GT should be considered in this population. Copyright © 2013 John Wiley & Sons, Ltd.
Comparison of abiraterone acetate versus ketoconazole in patients with metastatic castration resistant prostate cancer refractory to docetaxel
Authors: Peer Avivit , Gottfried Maya , Sinibaldi Victoria , Carducci Michael A. , Eisenberger Mario A. , Sella Avishay , Leibowitz‐Amit Raya , Berger Raanan , Keizman Daniel 
Published: December 2013

BACKGROUNDAbiraterone, a potent CYP 17 inhibitor, is standard treatment in docetaxel refractory, metastatic castrate resistant prostate cancer (mCRPC). However, in countries where abiraterone has not been approved yet, or for patients who cannot afford it, ketoconazole is used as an alternative CYP 17 inhibitor. Although preclinical data suggests that ketoconazole is a less potent inhibitor of CYP 17, there are limited clinical data comparing both agents. We aimed to compare the clinical effectiveness of abiraterone versus ketoconazole in docetaxel refractory mCRPC.METHODSRecords from mCRPC patients treated with ketoconazole (international multicenter database, n = 162) were reviewed retrospectively. Twenty‐six patients treated post docetaxel were individually matched by clinicopathologic factors to patients treated with abiraterone (national multicenter database, n = 140). We compared the PSA response, biochemical and radiological progression free survival (PFS), and overall survival (OS) between the groups. PFS and OS were determined by Cox regression.RESULTSThe groups were matched by Gleason score, pre‐treatment disease extent, ECOG PS, pre‐treatment risk category (Keizman, Oncologist 2012). Furthermore, they were balanced regarding other known confounding risk factors. In the groups of abiraterone versus ketoconazole, PSA response was 46% versus 19% (OR 4.3, P = 0.04), median biochemical PFS 7 versus 2 months (HR 1.54, P = 0.02), median radiological PFS 8 versus 2.5 months (HR 1.8, P = 0.043), median OS 19 versus 11 months (HR 0.53, P = 0.79), and treatment interruption d/t severe adverse events 8% (n = 2) versus 31% (n = 8) (0R 0.6, P = 0.023).CONCLUSIONSIn docetaxel refractory mCRPC, the outcome of abiraterone treatment may be superior to ketoconazole. Prostate 74:433–440, 2014. © 2013 Wiley Periodicals, Inc.
The expanded FindCore method for identification of a core atom set for assessment of protein structure prediction
Authors: Snyder David A. , Grullon Jennifer , Huang Yuanpeng J. , Tejero Roberto , Montelione Gaetano T. 
Published: December 2013

ABSTRACTMaximizing the scientific impact of NMR‐based structure determination requires robust and statistically sound methods for assessing the precision of NMR‐derived structures. In particular, a method to define a core atom set for calculating superimpositions and validating structure predictions is critical to the use of NMR‐derived structures as targets in the CASP competition. FindCore (Snyder and Montelione, Proteins 2005;59:673–686) is a superimposition independent method for identifying a core atom set and partitioning that set into domains. However, as FindCore optimizes superimposition by sensitively excluding not‐well‐defined atoms, the FindCore core may not comprise all atoms suitable for use in certain applications of NMR structures, including the CASP assessment process. Adapting the FindCore approach to assess predicted models against experimental NMR structures in CASP10 required modification of the FindCore method. This paper describes conventions and a standard protocol to calculate an “Expanded FindCore” atom set suitable for validation and application in biological and biophysical contexts. A key application of the Expanded FindCore method is to identify a core set of atoms in the experimental NMR structure for which it makes sense to validate predicted protein structure models. We demonstrate the application of this Expanded FindCore method in characterizing well‐defined regions of 18 NMR‐derived CASP10 target structures. The Expanded FindCore protocol defines “expanded core atom sets” that match an expert's intuition of which parts of the structure are sufficiently well defined to use in assessing CASP model predictions. We also illustrate the impact of this analysis on the CASP GDT assessment scores. Proteins 2014; 82(Suppl 2):219–230. © 2013 Wiley Periodicals, Inc.
The future for weed control and technology
Authors: Shaner Dale L , Beckie Hugh J 
Published: December 2013

AbstractThis review is both a retrospective (what have we missed?) and prospective (where are we going?) examination of weed control and technology, particularly as it applies to herbicide‐resistant weed management (RWM). Major obstacles to RWM are discussed, including lack of diversity in weed management, unwillingness of many weed researchers to conduct real integrated weed management research or growers to accept recommendations, influence or role of agrichemical marketing and governmental policy and lack of multidisciplinary research. We then look ahead to new technologies that are needed for future weed control in general and RWM in particular, in areas such as non‐chemical and chemical weed management, novel herbicides, site‐specific weed management, drones for monitoring large areas, wider application of ‘omics’ and simulation model development. Finally, we discuss implementation strategies for integrated weed management to achieve RWM, development of RWM for developing countries, a new classification of herbicides based on mode of metabolism to facilitate greater stewardship and greater global exchange of information to focus efforts on areas that maximize progress in weed control and RWM. There is little doubt that new or emerging technologies will provide novel tools for RMW in the future, but will they arrive in time? © 2013 Her Majesty the Queen in Right of Canada Pest Management Science © 2013 Society of Chemical Industry
Effect of solvent evaporation on the self‐assembly of poly(3‐hexylthiophene‐2,5‐diyl) and on the film morphology during electrospray deposition
Authors: Liao Yingjie , Fukuda Takeshi , Kamata Norihiko 
Published: December 2013

AbstractA high‐voltage rectangular pulse was applied to the electro‐spray deposition (ESD) to control the evaporation‐induced self‐assembly of poly(3‐hexylthiophene‐2,5‐diyl) (P3HT). Two groups of P3HT thin films were deposited by a series of high‐voltage rectangular pulses. Compared with the ESD driven by a constant voltage, the pulse‐driven ESD enables to probe the effect of solvent evaporation on the self‐assembly of P3HT molecules. The droplet size and the evaporation of residual solvent in the droplet determine the film morphology. Ultraviolet–visible absorption spectroscopy was used to identify the ordering of P3HT molecules in the films. The self‐assembly of P3HT molecules took place during the solvent evaporation which can be controlled by a combination of the pulse amplitude and the pulse interval. With an appropriate combination of the amplitude and the interval, the ESD produced a P3HT thin film with high chain ordering.magnified image(© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Two‐way regularization for MEG source reconstruction via multilevel coordinate descent
Authors: Siva Tian Tian , Huang Jianhua Z. , Shen Haipeng 
Published: December 2013

AbstractMagnetoencephalography (MEG) source reconstruction refers to the inverse problem of recovering the neural activity from the MEG time course measurements. A spatiotemporal two‐way regularization (TWR) method was recently proposed by Tianet al.to solve this inverse problem and was shown to outperform several one‐way regularization methods and spatiotemporal methods. This TWR method is a two‐stage procedure that first obtains a raw estimate of the source signals and then refines the raw estimate to ensure spatial focality and temporal smoothness using spatiotemporal regularized matrix decomposition. Although proven to be effective, the performance of two‐stage TWR depends on the quality of the raw estimate. In this paper we directly solve the MEG source reconstruction problem using a multivariate penalized regression where the number of variables is much larger than the number of cases. A special feature of this regression is that the regression coefficient matrix has a spatiotemporal two‐way structure that naturally invites a two‐way penalty. Making use of this structure, we develop a computationally efficient multilevel coordinate descent algorithm to implement the method. This new one‐stage TWR method has shown its superiority to the two‐stage TWR method in three simulation studies with different levels of complexity and a real‐world MEG data analysis. © 2013 Wiley Periodicals, Inc. Statistical Analysis and Data Mining, 2013
Preventive effect of different toothpastes on enamel erosion: AFM and SEM studies
Authors: Lombardini Marco , Ceci Matteo , Colombo Marco , Bianchi Stefano , Poggio Claudio 
Published: December 2013

SummaryThe aim of the present in vitro study was the evaluation of new formulation toothpastes on preventing enamel erosion produced by a soft drink (Coca Cola), using atomic force microscopy (AFM) and scanning electron microscopy (SEM). Fifty enamel specimens were assigned to 10 groups of 5 specimens each. 1: intact enamel, 2: enamel + soft drink, 3: intact enamel + BioRepair Plus‐Sensitive Teeth, 4: enamel + soft drink + BioRepair Plus‐Sensitive Teeth, 5: intact enamel + BioRepair Plus‐Total Protection, 6: enamel + soft drink + BioRepair Plus‐Total Protection, group 7: intact enamel + Sensodyne Repair & Protect, 8: dentin + soft drink + Sensodyne Repair & Protect, 9: intact dentin + Colgate Sensitive Pro Relief, 10: dentin + soft drink + Colgate Sensitive Pro Relief. The surface of each specimen was imaged by AFM and SEM. The root mean‐square roughness (Rrms) was obtained from the AFM images and the differences in the averaged values among the groups were analyzed by ANOVA test. Comparing groups 4, 6, 8, 10 (soft drink + toothpastes) Colgate Sensitive Pro Relief promoted enamel remineralization, while BioRepair Plus‐Sensitive Teeth, Biorepair Plus‐Total Protection and Sensodyne Repair & Protect provided lower effectiveness in protecting enamel against erosion. Significance: the use of new formulation toothpastes can prevent enamel demineralization. SCANNING 36:401–410, 2014. © 2013 Wiley Periodicals, Inc.
Publication rates of presentations given at annual conferences of The Wildlife Society, 1994–2006
Authors: McRoberts Jon T. , Ferguson Adam W. , Schwalm Donelle L. , Timmer Jennifer M. , Ballard Warren B. 
Published: December 2013

ABSTRACTAnnual conferences of The Wildlife Society (TWS) are important venues to advance wildlife science research through the presentation of papers and posters. However, no longitudinal analysis has been conducted of publication rates of TWS conference presentations. We classified all conference presentations from 1994 to 2006 by publication status, publication outlet, lead author affiliation, and elapsed time between presentation and publication to analyze presentation and publication trends. Of the 6,279 presentations reviewed, 1,771 were published (28.2%), primarily in the Journal of Wildlife Management (22.9%) or the Wildlife Society Bulletin (15.2%). The average time between presentation and publication was 30.1 ± 0.6 months. Academics provided most of the presentations (52.6%), as well as publications (62.4%). We believe consideration of TWS annual conference presentation and publication metrics by TWS membership and conference organizers is warranted to ensure maximum stakeholder benefit. We discuss these implications of publication analysis and offer suggestions for increasing publication rates, if that becomes a goal of TWS. We encourage periodic investigation to quantify conference benefits and to better assess the efficacy of TWS conferences. © 2013 The Wildlife Society.
Polynitro Containing Energetic Materials based on Carbonyldiisocyanate and 2, 2‐Dinitropropane‐1, 3‐diol
Authors: Klapötke Thomas M. , Krumm Burkhard , Rest Sebastian F. , Sućeska Muhamed 
Published: December 2013

AbstractNew polynitro compounds containing a carbonyl biscarbamate moiety derived from the precursor carbonyldiisocyanate were synthesized. In addition, 2, 2‐dinitropropane‐1, 3‐diyl bis(2, 2,2‐trinitroethylcarbamate) and 2, 2‐dinitropropane‐1, 3‐diyl bis(2, 2,2‐trinitroethyl) dicarbonate, were synthesized using 2, 2‐dinitropropane‐1, 3‐diol as starting material. The compounds were characterized by using the analytical methods, single‐crystal X‐ray diffraction, vibrational spectroscopy (IR and Raman), multinuclear NMR spectroscopy, elemental analysis, and mass spectrometry. The thermal behavior was investigated with DSC measurements. The suitability of the compounds as potential oxidizers in energetic formulations was determined. The heats of formation of the compounds were calculated with GAUSSIAN 09. The detonation parameters such as the detonation pressure, velocity, energy, and temperature were computed using the EXPLO5 code. For a secure handling of the materials, the sensitivity towards impact, friction, and electrical discharge was tested using the BAM drop hammer, BAM friction tester as well as a small‐scale electrical discharge device, respectively.
Castor bean growth and rhizosphere soil property response to different proportions of arbuscular mycorrhizal and phosphate‐solubilizing fungi
Authors: Zhang Huan Shi , Li Gang , Qin Feng Fei , Zhou Ming Xi , Qin Pei , Pan Shao Ming 
Published: December 2013

AbstractA pot culture experiment was performed to study the effects of infection with different proportions of arbuscular mycorrhizal fungus (AMF) and phosphate‐solubilizing fungus (PSF) on the rhizosphere soil property of castor bean (Ricinus communis L.). One AMF, Glomus mosseae, and one PSF, Mortierella sp. (Ms), were applied to non‐sterilized coastal saline soil. The plant dry mass, leaf chlorophyll content, and P‐uptake of castor bean were assessed. In coastal saline soil, the different proportions of both fungi‐inoculated seedlings showed significantly greater shoot and root dry weight than the controls, which had lower root‐to‐shoot ratios than the inoculated seedlings. An increase in phosphorus (P) and chlorophyll contents was also observed in the inoculated seedlings compared with the controls. The appropriate Ms proportion seemed to be advantageous for AMF colonization. However, available P content of fungi‐treated soil increased in proportion to the increase in Ms population and AMF colonization. By contrast, the pH of inoculated soil decreased because of the increased proportion of Mortierella, and electrical conductivity values showed a negative correlation with AMF colonization. Soil enzyme activities (i.e., urease, invertase, neutral phosphatase, and alkaline phosphatase) and soil organic matter were also stimulated by inoculation with different proportions of both fungi. However, the catalase activities of inoculated soil were inhibited compared with those of the control soil. Results from this study prove that castor bean planting associated with an appropriate proportion of AMF and PSF will benefit the amelioration of coastal saline soils of eastern China.
Ausgewählte Ionenkanalerkrankungen des peripheren Nervensystems
Authors: Borck G. , Kubisch C. 
Published: December 2013

Zusammenfassung
Ionenkanalerkrankungen des peripheren Nervensystems können sich primär als Syndrome mit veränderter Schmerzwahrnehmung oder als periphere Neuropathien manifestieren. Von besonderem Interesse sind die Erkrankungen, die durch Mutationen im SCN9A-Gen verursacht werden, das für den spannungsabhängigen Natriumkanal Nav1.7 kodiert. Während Gain-of-function-Mutationen in SCN9A die erbliche Erythromelalgie und andere seltene Erkrankungen verursachen, die mit starken Schmerzattacken einhergehen, wurden SCN9A-Funktionsverlustmutationen bei Patienten mit kompletter angeborener Schmerzinsensitivität identifiziert. Diese Erkrankungen und die durch Mutationen in TRPV4 („transient receptor potential channel 4“) bedingten Neuropathien, wie skapuloperoneale spinale Muskelatrophie und Charcot-Marie-Tooth-Erkrankung 2C, verdeutlichen die klinische Relevanz der Fehlfunktion von Ionenkanälen nicht nur im zentralen, sondern auch im peripheren Nervensystem.
Ionenkanalerkrankungen des Gehirns – monogene Migräneformen
Authors: Freilinger T. , Dichgans M. 
Published: December 2013

ZusammenfassungIm Gegensatz zu den häufigen genetisch komplexen Formen der Migräne existieren auch einige seltene monogene Migränevarianten. Klassischer Vertreter ist die sog. familiäre hemiplegische Migräne (FHM), eine schwere Unterform der Migräne mit Aura, für die mittlerweile 3 ursächliche Gene (FHM1–3; allesamt Ionenkanäle bzw. -transporter) bekannt sind. Dieser Artikel stellt den derzeitigen Wissensstand über Klinik, (Differenzial-)Diagnostik, Therapie, Genetik sowie Pathophysiologie der FHM kompakt dar. Dabei werden auch klinisch bzw. genetisch überlappende Erkrankungen, wie episodische Ataxie Typ 2 (EA-2), spinozerebelläre Ataxie Typ 6 (SCA-6), alternierende Hemiplegie der Kindheit (AHC), besprochen und neue Gene, die in Einzelfällen mit der HM oder Migräne in Verbindung gebracht werden, kritisch beleuchtet. Ergänzend werden monogene vaskuläre Syndrome besprochen, bei denen als Teil des Phänotyps eine Migräne auftritt.
Culture and Demography: From Reluctant Bedfellows to Committed Partners
Authors: Bachrach Christine A. 
Published: December 2013

Abstract
Demography and culture have had a long but ambivalent relationship. Cultural influences are widely recognized as important for demographic outcomes but are often “backgrounded” in demographic research. I argue that progress toward a more successful integration is feasible and suggest a network model of culture as a potential tool. The network model bridges both traditional (holistic and institutional) and contemporary (tool kit) models of culture used in the social sciences and offers a simple vocabulary for a diverse set of cultural concepts, such as attitudes, beliefs, and norms, as well as quantitative measures of how culture is organized. The proposed model conceptualizes culture as a nested network of meanings represented by schemas that range in complexity from simple concepts to multifaceted cultural models. I illustrate the potential value of a model using accounts of the cultural changes underpinning the transformation of marriage in the United States and point to developments in the social, cognitive, and computational sciences that could facilitate the application of the model in empirical demographic research.