bluuebunny/crossref_metadata_2025_split huggingface dataset:
Explainable machine learning framework to predict the risk of work-related neck and shoulder musculoskeletal disorders among healthcare professionals
Authors: Luo Na , Xu Xinyi , Jiang Biling , Zhang Zeyuan , Huang Jingyu , Zhang Xiulan , Tan Qiong , Wang Xuanyi , Bai Siyi , Liu Suyi , Pan Yishuang , Tang Chi , Zhu Pinghua 
Published: August 2024

ObjectiveThis study aims to develop risk prediction models for neck and shoulder musculoskeletal disorders among healthcare professionals.MethodsA stratified sampling method was employed to select employees from medical institutions in Nanning City, yielding 617 samples. The Boruta algorithm was used for feature selection, and various models, including Tree-Based Models, Single Hidden-Layer Neural Network Models (MLP), Elastic Net Models (ENet), and Support Vector Machines (SVM), were applied to predict the selected variables, utilizing SHAP algorithms for individual-level local explanations.ResultsThe SVM model excels in both Mean Absolute Error (MAE) and Root Mean Square Error (RMSE) and exhibits more stable performance when generalizing to unseen data. The Random Forest model exhibited relatively high overall performance on the training set. The MLP model emerges as the most consistent and accurate in predicting shoulder musculoskeletal disorders, while the SVM model shows strong fitting capabilities during the training phase, with occupational factors identified as the main contributors to WMSDs.ConclusionThis study successfully constructs work-related musculoskeletal disorder risk prediction models for healthcare professionals, enabling a quantitative analysis of the impact of occupational factors. This advancement is beneficial for future economical and convenient work-related musculoskeletal disorder screening in healthcare professions.
Knowledge, attitudes, and practices of family caregivers for patients with cerebral infarction toward home-based care
Authors: Chen Zhipeng , Zhou Xiaohua , Jiang Lu , Song Chunmei , Wang Shufang , Zhao Huilan , Liu Jianping , Ma Xiangxiang , Yu Jia 
Published: August 2024

ObjectiveThis study aimed to assess the knowledge, attitudes, and practices (KAP) among family caregivers of patients with cerebral infarction toward home-based care.MethodsThis web-based cross-sectional study was conducted between October 2023 and February 2024 at Yancheng Third People’s Hospital. A self-designed questionnaire was developed to collect demographic information, and assess the KAP among family caregivers of patients with cerebral infarction toward home-based care.ResultsA total of 761 questionnaires were included in the study. Among the participants, 453 (59.53%) were female, and 548 (72.01%) lived with the patients. The mean knowledge, attitudes and practices scores were 6.67 ± 1.73 (possible range: 0–9), 32.95 ± 2.46 (possible range: 9–45), and 28.64 ± 4.39 (possible range: 8–40), respectively. Path analysis showed the direct effect of knowledge on both attitudes (β = 0.885, p &lt; 0.001) and practices (β = 1.295, p &lt; 0.001), as well as of attitudes on practices (β = 0.838, p &lt; 0.001).ConclusionFamily caregivers of patients with cerebral infarction have sufficient knowledge, positive attitudes and proactive practices toward home-based care. However, they still exhibit deficiencies in certain aspects of knowledge, attitudes, and practice. Developing personalized educational strategies may be instrumental in enhancing family caregivers’ knowledge of home-based care. This, in turn, could improve their attitudes and elevate their practice levels.
Butyrylcholinesterase levels correlate with surgical site infection risk and severity after colorectal surgery: a prospective single-center study
Authors: Verras Georgios-Ioannis , Mulita Francesk 
Published: August 2024

IntroductionSurgical site infections (SSIs) after colorectal surgery remain a significant concern, which warrants effective predictive markers for prompt diagnosis and treatment. Butyrylcholinesterase (BChE), a non-specific cholinesterase enzyme, has been correlated with the risk of hepatic dysfunction progression and, more recently, infectious diseases and septic shock with ongoing research into the utility of BChE in multiple systemic inflammatory conditions. Whether these preliminary results can be translated into predicting infection after colorectal surgery remains in remains in question. This prospective study aimed to assess BChE's potential as a predictive marker for surgical site infections and anastomotic leaks after colorectal surgery.Materials and methodsThis single-center prospective study (11/2019–05/2023) enrolled 402 patients who underwent colorectal surgery. BChE levels were measured at four postoperative time points. The primary endpoints focused on BChE's association with complications, particularly surgical site infections (SSIs). Further known predictors of SSI were utilized to construct multivariable models to assess for independent association with SSI development.ResultsDuring the third and fifth day postsurgery, SSI patients had significantly lower mean BChE levels (3.90 KU/L vs. 4.54 KU/L p-value &lt; 0.05, and 4.14 KU/L vs. 4.73 KU/L, p-value &lt; 0.05; t-test, respectively). However, multivariate analysis revealed that when adjusted for other factors, low BChE levels on the first postoperative day were associated with 2.6 times higher odds of developing SSI (OR: 2.6, 95%CI: 1.3–3.9, p-value &lt; 0.05). Similar results were found for low BChE levels on the third postoperative day as they were associated with a. 2.53 times higher odds for developing SSI (OR: 2.5, 95%CI: 1.27–3.87, p-value &lt; 0.05) when adjusted for other factors.ConclusionIn conclusion, in this prospective observational study, low levels in the first and third postsurgery were associated with an increased risk for the development of SSIs but not sepsis.
Association between admission inflammatory indicators and 3-year mortality risk in geriatric patients after hip fracture surgery: a retrospective analysis of a prospective cohort study
Authors: Chen Yimin , Tu Chao , Liu Gang , Peng Weidong , Zhang Jing , Ge Yufeng , Tan Zhelun , Bei Mingjian , Gao Feng , Tian Maoyi , Yang Minghui , Wu Xinbao 
Published: August 2024

BackgroundRecent research indicates that the monocyte lymphocyte ratio (MLR), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), C-reactive protein (CRP), and systemic immune-inflammation index (SII) may serve as valuable predictors of early postoperative mortality in elderly individuals with hip fractures. The primary objective of the study was to examine the association between preoperative MLR, NLR, PLR, CRP, and SII levels and 3-year mortality risk in geriatric patients after hip fracture surgery.Patients and methodsThe study included patients aged 65 years or older who underwent hip fracture surgery between November 2018 and November 2019. Admission levels of MLR, NLR, PLR, CRP, and SII were measured. The median follow-up period was 3.1 years. Cox proportional hazards models were used to calculate the hazard ratio (HR) for mortality with adjusting for potential covariates. Time-dependent receiver operating characteristic (ROC) curves were employed to assess the predictive capability of inflammatory indicators for mortality.ResultsA total of 760 patients completed the follow-up (79.4 ± 7.8 years, 71.1% female). A higher preoperative MLR was found to be significantly associated with an increased 3-year postoperative mortality risk (HR 1.811, 95% CI 1.047–3.132, P = 0.034). However, no significant correlations were observed between preoperative NLR, PLR, CRP, SII and 3-year mortality. The areas under the ROC curve (AUCs) of MLR for predicting 30-day, 120-day, 1-year, and 3-year mortality were 0.74 (95% CI 0.53–0.95), 0.70 (95% CI 0.57–0.83), 0.67 (95% CI 0.60–0.74), and 0.61 (95% CI 0.56–0.66), respectively.ConclusionPreoperative MLR is a useful inflammatory marker for predicting 3-year mortality in elderly hip fracture patients, but its predictive ability diminishes over time.
Efficacy analysis of endovascular treatment for ruptured internal carotid artery pseudoaneurysm hemorrhage in patients with nasopharyngeal carcinoma after radiotherapy
Authors: Lin Zhipeng , Zou Xugong , Chen Yuan , Li Xiaoqun , Zhang Jian , Huang Dabei 
Published: August 2024

BackgroundThis study aims to evaluate the efficacy and complications of endovascular treatment for hemorrhage caused by ruptured internal carotid artery pseudoaneurysms following radiotherapy in nasopharyngeal carcinoma (NPC) patients.MethodsThis study retrospectively analyzed NPC patients who underwent endovascular treatment for ruptured internal carotid artery pseudoaneurysm hemorrhage after radiotherapy at Zhongshan People's Hospital from January 2016 to December 2022. The study aims to assess the postoperative hemostasis rate, postoperative rebleeding rate, complication rate, and 1-year postoperative survival rate.ResultsDuring the study period, 36 patients underwent endovascular treatment, of which 24 patients underwent embolization of the internal carotid artery and 12 patients underwent stenting of the internal carotid artery. The procedure success rate was 100%. The rebleeding rate at 1 year after the procedure was 5.6% (2/36, one patient with stent placement and one patient with coil embolization), and the complication rate was 11.1% (4/36, four patients with coil embolization patients). Two patients developed large-area cerebral infarction after the procedure, and two patients had different degrees of neurological impairment after the procedure. The 1-year survival rate was 91.7% (33/36).ConclusionRuptured internal carotid artery pseudoaneurysm hemorrhage after radiotherapy is rare but life-threatening. Endovascular treatment with coil occlusion or stenting reconstruction of the internal carotid artery provides immediate hemostasis and elimination of the pseudoaneurysm with a low rate of recurrence, which may be effective in reducing patient mortality.
Performance of three multiplex real-time PCR assays for simultaneous detection of 12 infectious pathogens in mice affected with respiratory and digestive diseases
Authors: Wang Hye-young , Ahn Jaeil , Lee Jonghoon , Kang Sang Chul , Kim Hyunil 
Published: August 2024

IntroductionResearch quality can be improved with reliable and reproducible experimental results when animal experiments are conducted using laboratory animals with guaranteed microbiological and genetic quality through health monitoring. Therefore, health monitoring requires the rapid and accurate diagnosis of infectious diseases in laboratory animals.MethodsThis study presents a performance evaluation of a commercially available multiplex real-time PCR (mRT-PCR) assay for the rapid detection of 12 infectious pathogens (Set 1: Sendai virus [SeV, formally murine respirovirus], Mycoplasma spp., Rodentibacter pneumotropicus, and Rodentibacter heylii; Set 2: Helicobacter spp., Murine norovirus [MNV], Murine hepatitis virus [MHV], and Salmonella spp.; Set 3: Staphylococcus aureus, Streptobacillus moniliformis, Corynebacterium kutscheri, and Pseudomonas aeruginosa). To evaluate the efficacy of the mRT-PCR assay, 102 clinical samples encompassing fecal and cecal specimens were analyzed. The resulting data were then compared with the findings from sequence analysis for validation.ResultsThe assay’s detection limit ranged from 1 to 100 copies per reaction. Specificity testing involving various viruses and bacteria indicated no cross-reactivity between strains. Additionally, the assay exhibited good reproducibility, with mean coefficients of variation for inter- and intra assay variation below 3%. The overall positive rate was 52.9% (n = 54), with the mRT-PCR assay findings matching sequence analysis results (κ = 1). MHV (n = 29, 28.4%) was the most prevalent pathogen, followed by Helicobacter spp. (n = 28, 27.5%), R. heylii (n = 18, 17.6%), Mycoplasma spp. (n = 14, 13.7%), MNV (n = 12, 11.8%), S. aureus (n = 9, 8.8%), P. aeruginosa (n = 4, 3.9%), and R. pneumotropicus (n = 1, 0.9%).DiscussionThis assay offers a rapid turnaround time of 100 min, including 30 min for DNA preparation and 70 min for target DNA/RNA amplification. It ensures accuracy, minimizing false positives or negatives, making it a convenient tool for the simultaneous detection of infectious diseases in many samples. Overall, the propose‑d assay holds promise for the effective detection of the most important pathogens in laboratory animal health monitoring.
Clickbait Contagion in International Quality Media: Tabloidisation and Information Gap to Attract Audiences
Authors: Diez-Gracia Alba , Sánchez-García Pilar , Palau-Sampio Dolors , Sánchez-Sobradillo Iris 
Published: August 2024

The competition to attract audiences has led to an increase in sensational or misleading headlines and content, with the aim of garnering user clicks in the news media. This dynamic alters the journalistic manner in which news is presented, and it does so by reducing informative quality and eroding the trust of the audience. This study examines the proliferation of clickbait strategies on the front pages of reputable international ‘serious’ press and how it manifests in readers’ consumption and sharing habits. We carried out a comparative content analysis of digital news articles from four international media sources (N = 1680): The Guardian (UK), The New York Times (USA), El País (Spain) and Público (Portugal). Our results confirm the existence of clickbait (N = 516) on the front pages, the most read content and the articles most shared on social media. Most clickbait titles resort to headline strategies of containing incomplete information that affect both hard and soft news topics. This particular finding highlights the inclusion of clickbait in the agenda of ‘serious’ journalism, despite the negative implications on information quality and trust. Associated with irrelevant content, this ‘hook’ captures the attention of the online audience more than the social media audience.
Parásito Cymothoa exigua en la ciudad de Riobamba, Ecuador: Análisis de prevalencia aplicando tecnologías básicas
Authors: Mora Andrés , Viteri Jimena , Mora Marilyn , Álvarez Kenny , Tiama Nicole 
Published: August 2024

Cymothoa exigua es un crustáceo isópodo de la familia Cymathoidae, que presenta alrededor de 42 géneros y 250 especies diversas. Este parásito ectoparásito se destaca por su amplia distribución geográfica. El objetivo del siguiente trabajo es estimar la prevalencia de este parásito en peces frescos comercializados en la ciudad de Riobamba. La investigación se realizó con un enfoque cuantitativo, de corte transversal y alcance descriptivo. Se tomaron muestras de peces en distintas zonas comerciales de la ciudad de Riobamba, incluyendo mercados y sitios de expendio de mariscos, donde se expende pescado procedente de la costa ecuatoriana. Se utilizó el método anatomopatológico y la técnica de la necropsia para intervenir cada pez, observar y describir las lesiones y parásitos en los casos positivos. Se encontró el parásito Cymothoa exigua en 15 de los 55 pescados analizados, lo que representa una prevalencia estimada del 27.27%. Se concluye que los peces de la especie Lutjanus campechanus que son expendidos en la ciudad de Riobamba, estaban parasitados con el isópodo Cymothoa exigua, siendo la prevalencia de un 27.27%. Se presume que existe una falta de control en la distribución y comercio de este tipo de pez entre región Costa a Sierra, o a su vez que los controles existentes no cumplen a cabalidad con la función para la detección de animales infectados; además, es vital considerar que, al ser animales extraídos de un ambiente no controlado, en este caso directamente del mar, la probabilidad de sufrir parasitismo aumenta exponencialmente.
Diphasic CeO
2
Nanocrystal/Bioactive Glass Nanosphere-Based Composite Hydrogel for Diabetic Wound Healing by Reactive Oxygen Species Scavenging and Inflammation Regulation
Authors: Qin Muyan , Zhu Ziyang , Ding Jingxin , Zhao Jinhui , Wang Lingtian , Jiang Dajun , Wang Deping , Jia Weitao 
Published: August 2024

Background:
Antioxidant therapy aimed at reducing excessive local oxidative stress is one of the most important strategies for promoting diabetic wound repair. The reversible transformation of Ce
3+
/Ce
4+
in ceria (CeO
2
) can reduce excessive local oxidative stress. However, inducing angiogenesis, local anti-inflammatory effects, and other positive effects are challenging. Therefore, ideal dressings for chronic diabetic wound management must concurrently reduce excessive oxidative stress, promote angiogenesis, and have anti-inflammatory effects.
Methods:
In this study, Ce-doped borosilicate bioactive glasses (BGs) were prepared using the sol–gel method, and CeO
2
nanocrystals (CeO
2
-NCs) were precipitated on the glass surface by heat treatment to obtain BG-
x
Ce composite glass nanospheres. Subsequently, nanospheres were modified by amino group and combined with dopamine and acrylamide to obtain BG-
x
Ce/polydopamine/polyacrylamide (PDA/PAM) composite hydrogel. Then, the morphology and properties of composite hydrogels were detected, and the properties to treat the diabetic wounds were also evaluated.
Results:
The results demonstrated that the BG-10Ce/PDA/PAM composite hydrogel possessed excellent tensile and adhesive properties. In vitro, the migration and angiogenesis of human umbilical vein endothelial cells (HUVECs) and fibroblasts (L929) were enhanced by reducing reactive oxygen species (ROS) levels in the conditioned medium. Animal experiments have shown that CeO
2
-NCs in hydrogels effectively scavenge ROS in diabetic wounds, and Sr dissolved from the glassy phase can modulate macrophage polarization to the M2 phenotype.
Conclusions:
The synergistic effect of both amorphous materials and nanocrystals provides the BG-10Ce/PDA/PAM composite hydrogel with great potential for diabetic wound healing.
PSYCHOLOGICAL FEATURES OF THE DOMINANT STRATEGY OF PSYCHOLOGICAL DEFENSE IN PATIENTS WITH OBSESSIVE-COMPULSIVE DISORDER
Authors: Халфина Р.Р. , Хабибуллина И.Р. , Тимербулатова М.Ф. 
Published: August 2024

На основе изученных научных подходов зарубежных и отечественных психологов становится ясно, что психологическая защита личности представляет собой выработанную в онтогенезе и присущую любому человеку стратегию бессознательного искажения аффективных и когнитивных аспектов тех ситуаций, которые несут угрозу сложившейся картине мира. Психологическая защита - это то, с помощью чего личность развивается целостно через адаптацию или устранение чувства тревоги, которое связанно с осознанием внутриличностного конфликта и преодолением психотравмирующей ситуации. В ходе исследования установлено, что обсессии и компульсии - банальные ритуализированные действия или психические акты, которые расцениваются пациентами как "защитные". Эти "защитные" действия представляют собой ритуалы, призванные «Вестник психофизиологии» №2 2020 120 предотвращать или минимизировать опасения больного. Когда ритуал будет совершен, то это приводит к тому, что больной испытывает временное облегчение. Нарушение каких-либо традиций, норм поведения, мыслей о нарушениях моральных предписаний вызывают защиту в виде навязчивостей, которые являются средством избежать каких-либо болезней, наказания в целом. Ключевые слова: психологические защиты, обсессивнокомпульсивное расстройство
On the basis of the studied scientific approaches of foreign and domestic psychologists, it becomes clear that the psychological protection of the individual is developed in ontogenesis and inherent in any person strategy of unconscious distortion of affective and cognitive aspects of those situations that threaten the current picture of the world. Psychological protection is something by which a person develops holistically through the adaptation or elimination of anxiety, which is associated with awareness of intrapersonal conflict and overcoming psychotraumatic situation. The study found that obsessions and compulsions - banal ritualized actions or mental acts, which are regarded by patients as "protective". These "protective" actions are rituals designed to prevent or minimize the patient's fears. When the ritual is performed, it leads to the fact that the patient experiences temporary relief. Violation of any traditions, norms behavior, thought about violations moral prescriptions cause protection in the form of obsessions, which are a means avoid any diseases, punishment in a whole. Key words: psychological defenses, obsessive compulsive disorder
PSYCHOLOGICAL FEATURES OF MANIFESTATIONWITH GAME COMPUTER ADDICTION (CYBERADDICTION) DEPENDING ON GENDER
Authors: Хох И.Р. , Халфина Р.Р. , Тимербулатов И.Ф. , Хабибуллина И.Р. 
Published: August 2024

В статье рассмотрены вопросы особенностей проявления кибераддикции в зависимости от гендерных различий. Установлены гендерные предпочтения в играх: респонденты женского пола предпочитают более спокойные и размеренные игры, не требующие активных и быстрых действий, и не содержащие соревновательного момента с другими игроками, мужчины же, напротив, преобладают в играх таких жанров, которые характеризуются быстротой действий, насилием, военным уклоном, включающие игрока в роль персонажа.
The article considers the issues of the peculiarities of the manifestation of cyberaddiction depending on gender differences. Gender preferences in games have been established: female respondents prefer more calm and measured games that do not require active and quick actions and do not contain a competitive moment with other players, while men, on the contrary, prevail in games of such genres that are characterized by speed of action, violence, military bias, including the player in the role of a character.
SOVIET HERITAGE OF MILITARY DOCTORS - ANTI-VIRAL THERAPY
Authors: Резункова О.П. 
Published: August 2024

У нас в стране новый класс высокоэффективных противоинфекционных препаратов начал своѐ формирование на основе исследований и клинической практики, начиная с работ, выполненных доктором В. Д. Макеевым на основе рецептурного применения веществ, сформированных позднее в формульную группу тролимед. Предлагаемые противовирусные формы лекарств отличаются от антибиотиков не только структурой, но и механизмом действия. Наиболее привлекательным из их качеств является нейтральное отношение к соматическим (здоровым) клеткам.
In our country, a new class of highly effective anti-infectious drugs began to form on the basis of research and clinical practice, starting with the work carried out by Dr. Makeev on the basis of prescription use of substances later formed into the trolimed formula group. The proposed antiviral forms of drugs differ from antibiotics not only in structure, but also in the mechanism of action. The most attractive of their qualities is a neutral attitude towards somatic (healthy) cells.
FEATURES OF THE EMOTIONAL SPHERE OF PRESCHOOL CHILDREN VISUALLY IMPAIRED
Authors: Быкова Е.Б. , Купцова Е.Д. 
Published: August 2024

В данной статье описывается экспериментальное исследование особенности эмоциональной сферы дошкольников с нарушениями зрения, целью которого является выявление трудностей, связанных с пониманием мимики, жестов, пантомимики дошкольниками, имеющими зрительную патологию. Актуальность выбранной темы исследования обусловлена тем, что дети с нарушением зрения развиваются по тем же законам, что и нормально видящие дети, однако нарушение понимания мимических и пантомимических проявлений партнёра в условиях зрительной депривации осложняет процесс общения, что препятствует их вхождению в социум.
This article describes an experimental study of the features of the emotional sphere of preschoolers with visual impairments, the purpose of which is to identify the difficulties associated with understanding facial expressions, gestures, pantomimes by preschoolers with visual pathology. The relevance of the chosen research topic is due to the fact that visually impaired children develop according to the same laws as normally seeing children, however, a violation of the understanding of the mimic and pantomimic manifestations of a partner in conditions of visual deprivation complicates the process of communication, which prevents them from entering society.