bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Effective Synthesis of Benzyl Halides Triggered by in situ Prepared Hypervalent Halides.
Authors: Ling Xue‐Ge , Xiong Yan , Zhang Shu‐Ting , Huang Ruo‐Feng , Zhang Xiao‐Hui 
Published: July 2013

AbstractDirect benzyl halogenation is achieved under conditions A) in the presence of CuI or CuBr with formation of monohalogenated products.
ChemInform Abstract: Enantioselective LaIII‐pyBOX‐Catalyzed Nitro‐Michael Addition to (E)‐2‐Azachalcones.
Authors: Blay Gonzalo , Incerti Celia , Munoz M. Carmen , Pedro Jose R. 
Published: July 2013

AbstractThis is the first catalytic asymmetric nitro‐Michael reaction with (E)‐2‐azachalcones.
ChemInform Abstract: Design, Synthesis, and Application of Novel Chiral ONN Ligands for Asymmetric Alkylation.
Authors: Bica Katharina , Leder Sonja , Mereiter Kurt , Gaertner Peter 
Published: July 2013

AbstractThe chiral ONN ligands are successfully used as catalysts for the addition of diethyl zinc (II) to various aromatic aldehydes leading to secondary alcohols.
ChemInform Abstract: Effective Palladium‐Catalyzed Hydroxycarbonylation of Aryl Halides with Substoichiometric Carbon Monoxide.
Authors: Korsager Signe , Taaning Rolf H. , Skrydstrup Troels 
Published: July 2013

AbstractThe presented mild reaction proceeds well with a number of aryl iodides and bromides, as well as aryl chlorides bearing electron poor substituents.
ChemInform Abstract: Mild Palladium‐Catalyzed Oxidative Direct ortho‐C—H Acylation of Anilides under Aqueous Conditions.
Authors: Szabo Fruzsina , Daru Janos , Simko Daniel , Nagy Tibor Zs. , Stirling Andras , Novak Zoltan 
Published: July 2013

AbstractThe rate accelerating effect of long chain anionic detergent and trifluoroacetic acid under aqueous conditions is shown.
ChemInform Abstract: Catalytic Enantioselective Decarboxylative Cyanoalkylation of Imines by Using Palladium Pincer Complexes with C2‐Symmetric Chiral Bis(imidazoline)s.
Authors: Hyodo Kengo , Kondo Masaru , Funahashi Yasuhiro , Nakamura Shuichi 
Published: July 2013

AbstractFor the first time the title reaction tolerating a range of imines is presented.
ChemInform Abstract: The Sulfinyl Group as a Remote Chiral Auxiliary in Stereoselective Conjugate Additions of Alkyl Groups to α‐Methylidene Carbonyl Compounds Initiated by Et3B/O2.
Authors: Fernandez‐Salas Jose Antonio , Maestro M. Carmen , Rodriguez‐Fernandez M. Mercedes , Garcia Ruano Jose L. 
Published: July 2013

AbstractThe outcome of this reaction depends on the type of radical used.
ChemInform Abstract: Heterobimetallic Ir—Sn Catalysis: Aza‐Friedel—Crafts Reaction of N‐Sulfonyl Aldimines.
Authors: Chatterjee Paresh Nath , Maity Arnab Kumar , Mohapatra Swapna Sarita , Roy Sujit 
Published: July 2013

AbstractThe authors present a convenient way for the formation of di‐ and triarylmethanes and heteroarylmethanes.
ChemInform Abstract: Palladium‐Catalyzed and Copper‐Mediated Cross‐Coupling Reaction of Aryl‐ or Alkenylboronic Acids with Acid Chlorides under Neutral Conditions: Efficient Synthetic Methods for Diaryl Ketones and Chalcones at Room Temperature.
Authors: Ogawa Daisuke , Hyodo Keita , Suetsugu Masato , Li Jing , Inoue Yoshiaki , Fujisawa Mamoru , Iwasaki Masayuki , Takagi Kentaro , Nishihara Yasushi 
Published: July 2013

AbstractThe non‐toxic and mild title reaction proceeds under strict non‐basic conditions for a wide range of substrates bearing an electron‐donating or an electron‐withdrawing substituent on the aromatic ring.
ChemInform Abstract: Palladium(II)‐Catalyzed Regioselective Arylation of Naphthylamides with Aryl Iodides Utilizing a Quinolinamide Bidentate System.
Authors: Huang Lehao , Li Qian , Wang Chen , Qi Chenze 
Published: July 2013

AbstractIn the presence of Pd(O‐Ac)2 1‐naphthylamides bearing a 2‐quinoline or 2‐pyridine directing group smoothly undergo regioselective reaction with a wide range of aryl iodides to afford 8‐arylated analogues.
ChemInform Abstract: Efficient Microwave‐Assisted One‐Pot Three‐Component Synthesis of 2,3‐Disubstituted Benzofurans under Sonogashira Conditions
Authors: Markina Nataliya A. , Chen Yu , Larock Richard C. 
Published: July 2013

AbstractMicrowave irradiation shortens reaction times and minimizes side products, making this methodology particularly useful for combinatorial chemistry.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Cross‐Coupling Between Heterocycles and Terminal Alkynes with Low Catalyst Loading.
Authors: Jie Xiaoming , Shang Yaping , Hu Peng , Su Weiping 
Published: July 2013

AbstractThe direct alkynylation of a variety of thiophenes and some other heterocyclic systems proceeds best with using Ag2O as the oxidant and affords structural motifs of bioactive products and pharmaceuticals.
ChemInform Abstract: A Simple and Efficient Synthesis of Dibenzothiophene via BF3·OEt2‐Promoted Intramolecular Annulation.
Authors: Shang Xiaobo , Chen Wanzhi , Yao Yingming 
Published: July 2013

AbstractMetal‐free decomposition of triazene‐substituted biphenyls offers a straightforward synthesis of dibenzothiophene derivatives with high functionality tolerance.
ChemInform Abstract: Tandem Aza‐Michael/Spiro‐Ring Closure Sequence: Access to a Versatile Scaffold and Total Synthesis of (.+‐.)‐Coerulescine.
Authors: Goermen Meral , Le Goff Ronan , Lawson Ata Martin , Daich Adam , Comesse Sebastien 
Published: July 2013

AbstractA simple protocol is presented for the tandem reaction between Michael acceptors (I) and carbamate (II) to yield pyrrolidine derivatives.
ChemInform Abstract: Chiral Phosphoric Acid‐Catalyzed Enantioselective Aza‐Friedel—Crafts Alkylation of Indoles with γ‐Hydroxy‐γ‐lactams.
Authors: Courant Thibaut , Kumarn Sirirat , He Long , Retailleau Pascal , Masson Geraldine 
Published: July 2013

AbstractThe reaction tolerates a wide range of substituents on the indole aromatic ring but is sensitive to the steric effects at the C2‐position [cf.
ChemInform Abstract: Methylene Acetal Formation from 1,2‐ and 1,3‐Diols Using an O,S‐Acetal, 1,3‐Dibromo‐5,5‐dimethylhydantoin, and BHT.
Authors: Maegawa Tomohiro , Koutani Yasuyuki , Otake Kazuki , Fujioka Hiromichi 
Published: July 2013

AbstractThis new, mild, and efficient method affords different substituted acetals after short reaction times.
ChemInform Abstract: Synthesis of Some Novel Thiosemicarbazone Derivatives Having Anticancer, anti‐HIV as well as Antibacterial Activity.
Authors: Patel Hitesh Dahyabhai , Divatia Saavani Malove , de Clercq Erik 
Published: July 2013

AbstractSome new thiosemicarbazones containing benzimidazole moiety (VI) are synthesized and screened for their ability to inhibit the growth of 60 human cancer cell lines, in vitro replication on HIV virus strains as well as inhibition capacity for several bacterial strains.
ChemInform Abstract: Microwave Assisted Aminomethylation of Some Heterocyclic Compounds Bearing Imidazolone Moiety and Their Biological Assay.
Authors: Vyas Ritu , Rawal Manish K. , Ameta Rakshit , Chittora Anil K. , Punjabi Pinki B. 
Published: July 2013

AbstractAll the synthesized Mannich bases (9 examples) except for (VIIId) exhibit moderate to excellent antibacterial and strong antifungal activities.
ChemInform Abstract: Synthesis of Phenylalaninol‐Derived Oxazolopyrrolidone Lactams and Evaluation as NMDA Receptor Antagonists.
Authors: Pereira Nuno A. L. , Sureda Francesc X. , Turch Mireia , Amat Mercedes , Bosch Joan , Santos Maria M. M. 
Published: July 2013

AbstractThe phenyl derivative (V*b) is found to be more potent as a NMDA receptor than amantadine.
ChemInform Abstract: Ammonium Metavanadate an Efficient Catalyst for Erlenmeyer Synthesis.
Authors: Madje Balaji , Ubale Milind , Bharad Jagdish , Shingare Murlidhar 
Published: July 2013

AbstractAn efficiently and environmentally friendly protocol for the synthesis of azlactone derivatives (III) (19 examples) via NH4VO3‐catalyzed condensation of hippuric acid (I) with carbonyl compounds (II) is developed.
ChemInform Abstract: Synthesis, Crystal Structure, and in vitro Antiprotozoal Activity of Some 5‐Phenyl(methyl)sulfonyl‐substituted Dihydroisoxazoles.
Authors: Dueruest Yasar , Altug Cevher , Kaiser Marcel , Fronczek Frank R. , Tasdemir Deniz 
Published: July 2013

AbstractTitle compounds are efficiently synthesized and tested for their antiprotozoal and cytotoxic activities.
ChemInform Abstract: Synthesis of Bis‐Acyclonucleoside Analogues Bearing Benzothienyl‐1,2,4‐triazol‐3‐yl‐disulfide under Conventional and Microwave Methods.
Authors: Aouad Mohamed R. , Rezki Nadjet , Messali Mouslim , El Ashry El Sayed H. 
Published: July 2013

AbstractTreatment of triazolethiol (I) with iodine and potassium iodide at room temperature gives rise to an oxidative dimerization affording triazoledisulfide (II).
ChemInform Abstract: Synthesis and Antifungal Potential of 3‐{4′‐(Chlorobenzyloxy)‐phenyl}‐4‐amino‐5‐mercapto‐1,2,4‐triazoles and Their Derivatives.
Authors: Rastogi Nisheeth , Kant Padam , Sethi Rakesh , Harrison Darwin Anil , Shukla Sarveshwar 
Published: July 2013

AbstractMost of the synthesized compounds show antifungal activity against human pathogenic fungi.
ChemInform Abstract: P2O5—SiO2 as an Efficient Heterogeneous Catalyst for the Solvent‐Free Synthesis of 1‐Substituted 1H‐1,2,3,4‐Tetrazoles under Conventional and Ultrasound Irradiation Conditions.
Authors: Habibi Davood , Nasrollahzadeh Mahmoud , Mehrabi Leila , Mostafaee Samaneh 
Published: July 2013

AbstractThe advantages of the title reaction are relatively short reaction times, ease of product isolation, and the use of a recoverable and reusable catalyst.
ChemInform Abstract: Enantioselective Phase‐Transfer Catalytic α‐Benzylation and α‐Allylation of α‐tert‐Butoxycarbonyllactones.
Authors: Park Hyeung‐geun , et al. et al. 
Published: July 2013

AbstractThe products are valuable building blocks for the preparation of the unnatural α‐quaternary homoserines, pyrrolidine and piperidine derivatives.
ChemInform Abstract: A Novel and Efficient Synthesis of 3‐[(4,5‐Dihydro‐1H‐pyrrol‐3‐yl)carbonyl]‐2H‐chromen‐2‐ones (= 3‐[(4,5‐Dihydro‐1H‐pyrrol‐3‐yl)carbonyl]‐2H‐1‐benzopyran‐2‐ones).
Authors: Alizadeh Abdolali , Ghanbaripour Rashid 
Published: July 2013

AbstractAn efficient one‐pot synthesis of the title benzopyran‐2‐one derivatives (V) by a four‐component reaction is reported.
ChemInform Abstract: First Selective Direct Mono‐Arylation of Piperidines Using Ruthenium‐Catalyzed C—H Activation.
Authors: Schwarz Maria C. , Dastbaravardeh Navid , Kirchner Karl , Schnuerch Michael , Mihovilovic Marko D. 
Published: July 2013

AbstractThe mono‐arylation in α‐position of saturated cyclic amines is presented.
ChemInform Abstract: Unsupported Nanoporous Gold Catalyst for Highly Selective Hydrogenation of Quinolines.
Authors: Jin Tienan , et al. et al. 
Published: July 2013

AbstractFor the first time, the highly efficient and regioselective hydrogenation of selected quinoline derivatives to 1,2,3,4‐tetrahydroquinolines using unsupported nanoporous gold as catalyst and organosilane with water as a hydrogen source is reported.
ChemInform Abstract: Enantioselective Iridium‐Catalyzed Hydrogenation of 1‐ and 3‐Substituted Isoquinolinium Salts.
Authors: Ye Zhi‐Shi , Guo Ran‐Ning , Cai Xian‐Feng , Chen Mu‐Wang , Shi Lei , Zhou Yong‐Gui 
Published: July 2013

AbstractA C3‐TunePhos is used as ligand in the title reaction to produce chiral products which represent subunits of pharmaceuticals.
ChemInform Abstract: Synthesis of Pyrazolo[1,5‐a]pyridines by Thermal Intramolecular Cyclization.
Authors: Hoashi Yasutaka , Takai Takafumi , Kotani Etsuo , Koike Tatsuki 
Published: July 2013

AbstractThe title reaction of N‐amino‐2‐alkynylpyridinium salts produces excellent yields of target heterocycles.
ChemInform Abstract: Ligand‐Free Palladium‐Catalyzed Intramolecular Arylation of Chromones: An Expedient Synthesis of 1‐Benzopyrano[3,2‐c]quinolines.
Authors: Ghosh Jaydip , Biswas Pritam , Maiti Sourav , Sarkar Tapas , Drew Michael G. B. , Bandyopadhyay Chandrakanta 
Published: July 2013

AbstractThe Pd‐catalyzed intramolecular arylation of Ugi products leads to formation of the novel ring system which is of biological interest.
ChemInform Abstract: An Efficient One‐Pot Four‐Component Synthesis of Functionalized Imidazo[1,2‐a]pyridines.
Authors: Movahed Siyavash Kazemi , Dabiri Minoo , Bazgir Ayoob 
Published: July 2013

AbstractA new one‐pot, four‐component, and catalyst‐free synthesis of highly functionalized imidazo[1,2‐a]pyridines is developed by condensing ethane‐1,2‐diamine, 1,2‐bis(methylthio)‐2‐nitroethene, aldehydes and activated methylene compounds.
ChemInform Abstract: Lithium Triflate (LiOTf): A Highly Efficient and Reusable Catalytic System for the Synthesis of Diversified Quinolines under Neat Conditions.
Authors: Atar Amol B. , Dindulkar Someshwer D. , Jeong Yeon Tae 
Published: July 2013

AbstractQuinolines [(III) and (V)] and acridines [(VII) and (IX)] are synthesized via Friedlander condensation.
ChemInform Abstract: Regioselective N‐Alkylation with Alcohols for the Preparation of 2‐(N‐Alkylamino)quinazolines and 2‐(N‐Alkylamino)pyrimidines.
Authors: Li Feng , Chen Lin , Kang Qikai , Cai Jianguang , Zhu Guangjun 
Published: July 2013

AbstractThe Ir‐catalyzed direct N‐alkylation reaction features easily available starting materials, high atom efficiency, and environmental benign conditions.
ChemInform Abstract: Regio‐ and Stereoselective Synthesis of Tri‐ and Tetrasubstituted Enamides via Palladium‐Catalyzed Silaboration of Ynamides.
Authors: Saito Nozomi , Saito Keiichi , Sato Hiroyasu , Sato Yoshihiro 
Published: July 2013

AbstractTri‐ and tetrasubstituted enamide derivatives are formed in highly regio‐ and stereoselective manner via a silaboration of ynamides.
ChemInform Abstract: Regio‐ and Stereoselective Hydrosilylation of 1,3‐Enynes Catalyzed by Palladium.
Authors: Zhou Hui , Moberg Christina 
Published: July 2013

AbstractIn the presence of Pd(0) and a phosphine, hydrosilylation of 1,3‐enynes with dimethylchlorosilane proceeds to yield dienylsilanes with the silicon function added to the internal alkyne carbon atom and with (E)‐configuration of the newly formed olefinic bond.
ChemInform Abstract: Inhibitory Effects of the Constituents of Hippophae rhamnoides on 3T3‐L1 Cell Differentiation and Nitric Oxide Production in RAW264.7 Cells.
Authors: Yang Zhi‐Gang , Wen Xiu‐Feng , Li Yong‐Hai , Matsuzaki Keiichi , Kitanaka Susumu 
Published: July 2013

AbstractThe flavonol glycosides, hippophaeossides A‐C (I*a‐c) are isolated along with 27 known compounds from the leaves of Hippophae rhamnoides L.
ChemInform Abstract: Structural and Optoelectronic Characterization of RF Sputtered ZnSnN2.
Authors: Lahourcade Lise , Coronel Naomi C. , Delaney Kris T. , Shukla Sujeet K. , Spaldin Nicola A. , Atwater Harry A. 
Published: July 2013

AbstractThin films of stoichiometric ZnSnN2, a new earth‐abundant small bandgap semiconductor, are prepared by reactive RF magnetron sputter deposition from Zn0.75Sn0.25 or from elemental Zn and Sn at about 250 °C in an atmosphere of Ar and N2.
ChemInform Abstract: Diels—Alder Reaction of Electron‐Deficient 2H‐Pyran‐2‐ones with Vinyl Moiety Containing Dienophiles and Characterization of the Intermediate Products
Authors: Juranovic Amadej , Kranjc Kristof , Keglevich Gyorgy , Polanc Slovenko , Kocevar Marijan 
Published: July 2013

AbstractReview: 27 refs.
ChemInform Abstract: Allicin and Related Compounds: Biosynthesis, Synthesis and Pharmacological Activity
Authors: Ilic Dusica P. , Nikolic Vesna D. , Nikolic Ljubisa B. , Stankovic Mihajlo Z. , Stanojevic Ljiljana P. , Cakic Milorad D. 
Published: July 2013

AbstractReview: 43 refs.
ChemInform Abstract: Crossed and Linked Histories of Tetrapyrrolic Macrocycles and Their Use for Engineering Pores Within Sol—Gel Matrices
Authors: Garcia‐Sanchez Miguel A. , Rojas‐Gonzalez Fernando , Menchaca‐Campos E. Carmina , Tello‐Solis Salvador R. , Quiroz‐Segoviano R. Iris Y. , Diaz‐Alejo Luis A. , Salas‐Banales Eduardo , Campero Antonio 
Published: July 2013

AbstractReview: 454 refs.
Fostering partnerships and program success
Authors: Phillips‐Angeles Ellen , Song Lin , Hannon Peggy A. , Celedonia Megan , Stearns Steven , Edwards Kris , Feest Scott , Shumann Amy 
Published: July 2013

BACKGROUNDFostering partnerships was critical to the success of the Colon Health Program (CHP) in Greater Seattle. The CHP was built on the Breast and Cervical Health Program (BCHP) framework. A replicable system to provide quality colorectal screening services for individuals with limited incomes and no health insurance was developed.METHODSPartners were recruited and engaged during 3 programmatic phases: 1) development and start‐up, 2) implementation, and 3) sustainability planning. Several tactics were used to develop trust and build bridges among the partners and to create an effective work group.RESULTSThe partners were critical to developing clinic policies, procedures, and systems to increase colorectal screening and improve follow‐up; expanding access to colonoscopies; and initiating statewide dissemination of training and systems as well as policy change. The fecal occult blood test completion rate was 61%, and the colonoscopy completion rate was 78%. The colonoscopy navigation system was effective with a low “no show” rate (8%). The partners were instrumental in helping Washington State obtain funding from the Centers for Disease Control and Prevention to continue the CHP statewide.CONCLUSIONSDuring implementation, key elements for success included: building the project on the successful BCHP framework, meticulous training of clinic staff about colorectal cancer and screening methods, frequent consultation to identify and solve problems, active support of the clinic administration, and the presence of a CHP champion in the clinic. Institutionalization of the CHP depended on: assessing progress after the first year, documenting experience with the program, disseminating lessons learned, engaging new partners, and determining steps to expand the program. Cancer 2013;119(15 suppl):2884–93. © 2013 American Cancer Society.
Delivering colonoscopy screening for low‐income populations in Suffolk County
Authors: Lane Dorothy S. , Messina Catherine R. , Cavanagh Mary F. , Anderson Joseph C. 
Published: July 2013

BACKGROUNDCurrent and pending legislation provides colorectal cancer screening reimbursement for previously uninsured populations. Colonoscopy is currently the screening method most frequently recommended by physicians for insured patients. The experience of the SCOPE (Suffolk County Preventive Endoscopy) demonstration project (Project SCOPE) at Stony Brook University Medical Center provides a model for delivering colonoscopy screening to low‐income populations to meet anticipated increasing demands.METHODSProject SCOPE, based in the Department of Preventive Medicine, featured internal collaboration with the academic medical center's large gastroenterology practice and external collaboration with the Suffolk County Department of Health Services' network of community health centers. Colonoscopies were performed by faculty gastroenterologists or supervised fellows. Measures of colonoscopy performance were compared with quality indicators and differences between faculty and supervised fellows were identified.RESULTSDuring a 40‐month screening period, 800 initial colonoscopies were performed. Approximately 21% of women screened were found to have adenomatous polyps compared with 36% of men. Five cancers were detected. The majority of the population screened (70%) were members of minority populations. African American individuals had a higher percentage of proximally located adenomas (78%) compared with white individuals (65%) and Hispanics (49%), based on the location of the most advanced lesion. Hispanic individuals had a 36% lower risk of adenomas compared with white individuals. Performance measures including the percentage of procedures with adequate bowel preparation, cecum reached, scope withdrawal time, and adenoma detection rate met quality benchmarks when performed by either faculty or supervised fellows.CONCLUSIONSProject SCOPE's operational strategies demonstrated a feasible method for an academic medical center to provide high‐quality screening colonoscopy for low‐income populations. Cancer 2013;119(15 suppl):2842–8. © 2013 American Cancer Society.
Recruiting patients into the CDC's Colorectal Cancer Screening Demonstration Program
Authors: Boehm Jennifer E. , Rohan Elizabeth A. , Preissle Judith , DeGroff Amy , Glover‐Kudon Rebecca 
Published: July 2013

BACKGROUNDIn 2005, the Centers for Disease Control and Prevention (CDC) funded 5 sites as part of the Colorectal Cancer Screening Demonstration Program (CRCSDP) to provide colorectal cancer screening to low‐income, uninsured, and underinsured individuals. Funded sites experienced unexpected challenges in recruiting patients for services.METHODSThe authors conducted a longitudinal, qualitative case study of all 5 sites to document program implementation, including recruitment. Data were collected during 3 periods over the 4‐year program and included interviews, document review, and observations. After coding and analyzing the data, themes were identified and triangulated across the research team. Patterns were confirmed through member checking, further validating the analytic interpretation.RESULTSDuring early implementation, patient enrollment was low at 4 of the 5 CRCSDP sites. Evaluators found 3 primary challenges to patient recruitment: overreliance on in‐reach to National Breast and Cervical Cancer Early Detection Program patients, difficulty keeping colorectal cancer screening and the program a priority among staff at partnering primary care clinics responsible for patient recruitment, and a lack of public knowledge about the need for colorectal cancer screening among patients. To address these challenges, site staff expanded partnerships with additional primary care networks for greater reach, enhanced technical support to primary care providers to ensure more consistent patient enrollment, and developed tailored outreach and education.CONCLUSIONSRemoving financial barriers to colorectal cancer screening was necessary but not sufficient to reach the priority population. To optimize colorectal cancer screening, public health practitioners must work closely with the health care sector to implement evidence‐based, comprehensive strategies across individual, environmental, and systems levels of society. Cancer 2013;119(15 suppl):2914–25. © 2013 American Cancer Society.
The relationship of family characteristics and bipolar disorder using causal-pie models
Authors: Chen Y.-C. , Kao C.-F. , Lu M.-K. , Yang Y.-K. , Liao S.-C. , Jang F.-L. , Chen W.J. , Lu R.-B. , Kuo P.-H. 
Published: July 2013

AbstractMany family characteristics were reported to increase the risk of bipolar disorder (BPD). The development of BPD may be mediated through different pathways, involving diverse risk factor profiles. We evaluated the associations of family characteristics to build influential causal-pie models to estimate their contributions on the risk of developing BPD at the population level. We recruited 329 clinically diagnosed BPD patients and 202 healthy controls to collect information in parental psychopathology, parent-child relationship, and conflict within family. Other than logistic regression models, we applied causal-pie models to identify pathways involved with different family factors for BPD. The risk of BPD was significantly increased with parental depression, neurosis, anxiety, paternal substance use problems, and poor relationship with parents. Having a depressed mother further predicted early onset of BPD. Additionally, a greater risk for BPD was observed with higher numbers of paternal/maternal psychopathologies. Three significant risk profiles were identified for BPD, including paternal substance use problems (73.0%), maternal depression (17.6%), and through poor relationship with parents and conflict within the family (6.3%). Our findings demonstrate that different aspects of family characteristics elicit negative impacts on bipolar illness, which can be utilized to target specific factors to design and employ efficient intervention programs.