bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nrf2 sensitizes prostate cancer cells to radiation via decreasing basal ROS levels
Authors: Liu Min , Yao Xu‐Dong , Li Wei , Geng Jiang , Yan Yang , Che Jian‐Ping , Xu Yun‐Fei , Zheng Jun‐Hua 
Published: February 2015

AbstractAndrogen deprivation therapy (ADT) was reported to lower basal ROS level in prostate cancer (PCa) and to sensitize PCa to radiation. We aimed to seek for the underlying molecular mechanism and to develop novel additive treatments to ADT in this regard. We simulated human androgen milieu in vitro and tested the ROS level in PCa cells undergoing ADT. We also tested the Nrf2 level in PCa cells with or without ADT. Genetic and pharmaceutical upregulation of Nrf2 was applied in vitro and in vivo in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice with or without castration to investigate whether Nrf2 overexpression supplemented the effect of ADT in PCa. We first discovered that androgen deprivation increased basal ROS level in PCa cells with AR expression. We then found that genetic Nrf2 upregulation lowered basal ROS similar to ADT. Also, SFN sensitized PCa cell to radiation via upregulation of Nrf2. We then found that Nrf2 level in control TRAMP groups was lower than castration or SFN groups. The SFN treated TRAMP mice showed similar level of Nrf2 to castration. Genetic and pharmaceutical upregulation of Nrf2 lowered the ROS in PCa cells and sensitized PCa cells to radiation similar to ADT, implicating possible administration of SFN in place of ADT for PCa patients requiring radiotherapy. © 2015 BioFactors, 41(1):52–57, 2015
Microtubule‐based nanomaterials: Exploiting nature's dynamic biopolymers
Authors: Bachand George D. , Spoerke Erik D. , Stevens Mark J. 
Published: February 2015

ABSTRACTFor more than a decade now, biomolecular systems have served as an inspiration for the development of synthetic nanomaterials and systems that are capable of reproducing many of unique and emergent behaviors of living systems. One intriguing element of such systems may be found in a specialized class of proteins known as biomolecular motors that are capable of performing useful work across multiple length scales through the efficient conversion of chemical energy. Microtubule (MT) filaments may be considered within this context as their dynamic assembly and disassembly dissipate energy, and perform work within the cell. MTs are one of three cytoskeletal filaments in eukaryotic cells, and play critical roles in a range of cellular processes including mitosis and vesicular trafficking. Based on their function, physical attributes, and unique dynamics, MTs also serve as a powerful archetype of a supramolecular filament that underlies and drives multiscale emergent behaviors. In this review, we briefly summarize recent efforts to generate hybrid and composite nanomaterials using MTs as biomolecular scaffolds, as well as computational and synthetic approaches to develop synthetic one‐dimensional nanostructures that display the enviable attributes of the natural filaments. Biotechnol. Bioeng. 2015;112: 1065–1073. © 2015 Wiley Periodicals, Inc.
A validated sensitive HPLC‐MS/MS method for quantification of a potential hypnotic drug MT502 and its application to a pharmacokinetic study in rat
Authors: Zhang Fang‐Fang , Cheng Ying , Wan Ning , Jing Zi‐Wei , Ju Jia , Jia Yi‐Yang , Zhou Si‐Yuan , Zhang Bang‐Le 
Published: February 2015

AbstractA rapid, sensitive HPLC‐MS/MS method was established and validated to assay the concentration and pharmacokinetic profile of MT502, a promising hypnotic drug. The plasma sample was treated by a liquid–liquid extraction and separated on a kromasil C18 column at an isocratic flow rate of 0.3 mL/min using methanol and 0.1% formic acid in water (75:25, v/v) as mobile phase. The mass spectrometric detection was carried out using a triple‐quadrupole system via positive electrospray ionization. Multiple reaction monitoring was used for quantitation of m/z transitions from 261 to 188 for MT502 and from 247 to 188 for MT501 (internal standard). Good linearity was achieved over the concentration range of 1–1000 ng/mL and 10–5000 ng/mL with lower limit of quantification of 0.30 and 0.80 ng/mL. The intra‐ and inter‐day precisions, accuracy, recovery and stability were satisfactory for the concentration test. The above method can be used for a pharmacokinetic study at doses of 1, 5 and 20 mg/kg. Results indicated that MT502 had rapid absorption, rapid elimination and linear pharmacokinetic properties within the range of the tested intragastric dose. This developed HPLC‐MS/MS method was successfully applied to a pharmacokinetic study of MT502 for the first time and was demonstrated to be simple and sensitive. Copyright © 2015 John Wiley & Sons, Ltd.
Synthesis of Sn‐Beta with Exclusive and High Framework Sn Content
Authors: van der Graaff William N. P. , Li Guanna , Mezari Brahim , Pidko Evgeny A. , Hensen Emiel J. M. 
Published: February 2015

AbstractSn‐Beta zeolite was prepared by acid dealumination of Beta zeolite, followed by dehydration and impregnation with anhydrous SnCl4. The formation of extraframework Sn (EFSn) species was prevented by the removal of unreacted SnCl4 in a methanol washing step prior to calcination. The resulting Sn‐Beta zeolites were characterized by X‐ray diffraction, Ar physisorption, NMR, UV/Vis, and FTIR spectroscopy. These well‐defined Lewis acid zeolites exhibit good catalytic activity and selectivity in the conversion of 1,3‐dihydroxyacetone to methyl lactate. Their performance is similar to a reference Sn‐Beta zeolite prepared by hydrothermal synthesis. Sn‐BEA zeolites that contain EFSn species exhibit lower catalytic activity; the EFSn species also catalyze formation of byproducts. DFT calculations show that partially hydrolyzed framework Sn‐OH species (open sites), rather than the tetrahedral framework Sn sites (closed sites), are the most likely candidate active sites for methyl lactate formation.
Methode zur Untersuchung der Partikelbewegung in diskontinuierlich und kontinuierlich arbeitenden Wirbelschichten
Authors: Idakiev Vesselin V. , Mörl Lothar 
Published: February 2015

AbstractEin neuartiges Verfahren, das magnetische Monitoring, wurde zur Bestimmung der Partikelbewegung eines magnetisch markierten Teilchens im Partikelkollektiv in diskontinuierlich sowie kontinuierlich arbeitenden Wirbelschichten eingesetzt. Die Position in x‐, y‐ und z‐Richtung und die räumliche Ausrichtung des Markers wird gemessen. Daraus lassen sich die Geschwindigkeit, die Beschleunigung, die auf die Partikel wirkenden Kräfte und Energien sowohl für die Translation als auch für die Rotation der Partikel berechnen. In der vorliegenden Arbeit wurden die Bewegungskennwerte der Partikel ermittelt. Des Weiteren wurde der Einfluss von verschiedenen Apparate‐ und Betriebsparametern auf die Bewegungskennwerte untersucht.
Gender‐Related Mortality and In‐Hospital Complications Following ST‐Segment Elevation Myocardial Infarction: Data From a Primary Percutaneous Coronary Intervention Cohort
Authors: Laufer‐Perl Michal , Shacham Yacov , Letourneau‐Shesaf Sivan , Priesler Ofir , Keren Gad , Roth Arie , Steinvil Arie 
Published: February 2015

ABSTRACTBackgroundThe increased mortality related to female gender in ST‐segment elevation myocardial infarction (STEMI) patients treated with primary percutaneous coronary intervention (PPCI) has been reported from various patient cohorts and treatment strategies with controversial results. In the present work, we evaluated the impact of female gender on mortality and in‐hospital complications among a specific subset of consecutive STEMI patients managed solely by PPCI.HypothesisFemale gender is not an independent predicor for mortality among STEMI patients.MethodsWe performed a retrospective, single‐center observational study that included 1346 consecutive STEMI patients undergoing PPCI, of which 1075 (80%) were male. Patient's records were evaluated for 30‐day mortality, in‐hospital complications, and long‐term mortality over a mean period of 2.7 ± 1.6 years.ResultsCompared with males, females were older (69 ± 13 vs 60 ± 13 years, P < 0.001), had a significantly higher rate of baseline risk factors, and had prolonged symptom duration (460 ± 815 minutes vs 367 ± 596 minutes, P = 0.03). Females suffered from more in‐hospital complications and had higher 30‐day mortality (5% vs 2%, P = 0.008) as well as higher overall mortality (12.5% vs 6%, P < 0.001). In spite of the significant mortality risk in unadjusted models, a multivariate adjusted Cox regression model did not demonstrate that female gender was an independent predictor for mortality among STEMI patients.ConclusionsAmong patients with STEMI treated by PPCI, female gender is associated with a higher 30‐day mortality and complications rates compared to males. Following multivariate analysis, female gender was not a significant predictor of long‐term death following STEMI.
Treatment‐related toxicities in older adults with head and neck cancer: A population‐based analysis
Authors: O'Neill Caitriona B. , Baxi Shrujal S. , Atoria Coral L. , O'Neill James P. , Henman Martin C. , Sherman Eric J. , Lee Nancy Y. , Pfister David G. , Elkin Elena B. 
Published: February 2015

BACKGROUNDDespite advantages in terms of cancer control and organ preservation, the benefits of chemotherapy and radiation therapy (CTRT) may be offset by potentially severe treatment‐related toxicities, particularly in older patients. The objectives of this study were to assess the types and frequencies of toxicities in older adults with locally or regionally advanced head and neck squamous cell carcinoma (HNSCC) who were receiving either primary CTRT or radiation therapy (RT) alone.METHODSWith Surveillance, Epidemiology, and End Results cancer registry data linked with Medicare claims, patients who were 66 years old or older with locally advanced HNSCC, were diagnosed from 2001 to 2009, and received CTRT or RT alone were identified. Differences in the frequency of toxicity‐related hospital admissions and emergency room visits as well as feeding tube use were examined, and controlling for demographic and disease characteristics, this study estimated the impact of chemotherapy on the likelihood of toxicity.RESULTSAmong patients who received CTRT (n = 1502), 62% had a treatment‐related toxicity, whereas 46% of patients who received RT alone (n = 775) did. When the study controlled for demographic and disease characteristics, CTRT patients were twice as likely to experience an acute toxicity in comparison with their RT‐only peers. Fifty‐five percent of CTRT patients had a feeding tube placed during or after treatment, whereas 28% of the RT‐only group did.CONCLUSIONSIn this population‐based cohort of older adults with HNSCC, the rates of acute toxicities and feeding tube use in patients receiving CTRT were considerable. It is possible that for certain older patients, the potential benefit of adding chemotherapy to RT does not outweigh the harms of this combined‐modality therapy. Cancer 2015. © 2015 American Cancer Society. Cancer 2015;121:2083–2089. © 2015 American Cancer Society.
Hydrothermal Targeted‐Explosion Synthesis of Hollow/Porous Upconversion Nano‐ and Microcrystals with Potential for Luminescent Displays and Biological Imaging
Authors: Qiu Peiyu , Sun Rongjin , Gao Guo , Chen Bin , Zhang Chunlei , Yin Ting , Zhang Jingpu , Fang Shan , Cui Daxiang 
Published: February 2015

AbstractA facile, one‐pot, hydrothermal ‘targeted‐explosion’ strategy was developed to construct β‐NaGdF4 and β‐NaYF4 hollow/porous upconversion nano‐ and microcrystals. We found that potassium sodium tartrate (PST) strongly complexes rare earth ions, which can reduce the reaction speed between rare earth ions and fluorine ions, leading to size‐ and morphology‐controlled crystals in a hydrothermal synthesis. Moreover, we simulated the ‘targeted‐explosion’ reaction process through structural mechanics finite element calculations to validate the feasibility of a ‘layer‐by‐layer blasting’ mechanism. Finally, we fabricated various models to show the potential of these materials for luminescent displays and as rare earth illuminants excited by near‐infrared light. In addition, the synthesized hollow/porous upconversion crystals were used for different types of biological imaging.
Temperature‐Dependent Immobilization of a Tungsten Peroxo Complex That Catalyzes the Hydroxymethoxylation of Olefins
Authors: Chen Jizhong , Hua Li , Chen Chen , Guo Li , Zhang Ran , Chen Angjun , Xiu Yuhe , Liu Xuerui , Hou Zhenshan 
Published: February 2015

AbstractA tungsten peroxo complex stabilized by the bidentate picolinato ligand has been synthesized and then immobilized successfully on imidazole‐functionalized silica. The immobilized tungsten‐based catalyst was employed as an efficient catalyst for the one‐pot synthesis of β‐alkoxy alcohols from olefins and methanol with H2O2. Regarding the catalyst evaluation and the results of characterization by the various methods, it was demonstrated that the immobilization of tungsten peroxo complex was highly temperature‐dependent. The tungsten peroxo complex can dissociate and diffuse into the liquid phase at reaction temperature, resulting in a homogeneous reaction. Nevertheless, the catalytically active species was anchored on the imidazole‐functionalized silica by hydrogen bonding as the temperature was lowered to 0 °C after the reaction, which thus offered a highly effective approach for recycling the catalyst for consecutive cycles. In addition, various olefins can be converted to the corresponding β‐alkoxy alcohols with good conversion and selectivity under relative mild conditions by H2O2.
Three‐Dimensional Arrays of 1D MnO2 Nanocrystals for All‐Solid‐State Asymmetric Supercapacitors
Authors: Dubal Deepak P. , Holze Rudolf , Gomez‐Romero Pedro 
Published: February 2015

AbstractReported is the synthesis of 3D hierarchical structures based on one‐dimensional MnO2 nanobuilding blocks (nanorods, nanowires, and nanoneedles) by means of a facile and scalable coprecipitation method and their use as electrodes for the assembly of all‐solid‐state supercapacitors. Asymmetric devices were also assembled by using these nanostructured MnO2 materials as the positive electrode and reduced graphene oxide (rGO) as the negative electrode with a polymeric gel electrolyte. The asymmetric cells successfully extend the working voltage windows beyond 1.4 V and allowed for a maximum voltage of 1.8 V. An asymmetric device based on hierarchical nanoneedle‐like MnO2 and rGO achieved a maximum specific capacitance of 99 F g−1 at a scan rate of 10 mV s−1 with a stable operational voltage of 1.8 V. This high value allowed for a large specific energy of 24.12 Wh kg−1.
Interpersonal Subtypes and Therapy Response in Patients Treated for Posttraumatic Stress Disorder
Authors: König Julia , Onnen Margarete , Karl Regina , Rosner Rita , Butollo Willi 
Published: February 2015

Interpersonal traits may influence psychotherapy success. One way of conceptualizing such traits is the interpersonal circumplex model. In this study, we analyse interpersonal circumplex data, assessed with the Inventory of Interpersonal Problems (Horowitz, Strauß, & Kordy, 1994) from a randomized study with 138 patients suffering from posttraumatic stress disorder after trauma in adulthood. The study compared cognitive processing therapy and dialogical exposure therapy, a Gestalt‐based intervention. We divided the interpersonally heterogeneous sample according to the quadrants of the interpersonal circumplex. The division into quadrants yielded subgroups that did not differ in their general psychological distress, but the cold‐submissive quadrant tended to exhibit higher posttraumatic stress disorder symptom severity and interpersonal distress than the other three. There was also a trend for patients in different quadrants to be affected differently by the treatments. Correlation analyses supported these results: in cognitive processing therapy, more dominant patients had more successful therapies, while in dialogical exposure therapy, success was not correlated with interpersonal style. Results indicate that especially patients with cold interpersonal styles profited differentially from the two treatments offered. Dividing samples according to the interpersonal circumplex quadrants seems promising. Copyright © 2015 John Wiley & Sons, Ltd.Key Practitioner Message:

Interpersonal traits may contribute to psychotherapy outcome.
Dividing the sample according to the quadrants of the interpersonal circumplex, as opposed to cluster analysis, yielded promising results.
Patients higher in dominance fared better with cognitive processing therapy, while interpersonal style had no correlations with therapy success in dialogical exposure therapy.
Pressure‐Driven Enthalpic and Lifshitz Transition in 122‐Pnictides
Authors: Quader K.F. , Widom M. 
Published: February 2015

AbstractIron‐arsenic pnictides are a class of compounds in which strong Coulomb interactions manifest in novel prop¬erties. We discuss basic ideas behind a Lifshitz transition and review salient properties of 122‐pnictides (AFe2As2; A = Ca, Sr, Ba, Ra). Using T = 0 first principles total energy calculations, as a function of hydro¬static pressure, we show that several pressure‐driven anomalies, and the tetragonal (T) to collapsed tetragonal (cT) phase transition in the 122‐pnictides family, can be understood as consequences of Lifshitz transitions arising from nontrivial changes in Fermi surface topology. We also show that several features found in our calculations, namely, enthalpic, magnetic and T‐cT transitions, are universal to the 122‐pnictides. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Fine needle aspiration of thyroid nodules in the pediatric population: A 12‐year cyto‐histological correlation experience at north shore‐long island jewish health system
Authors: Lale Seema A. , Morgenstern Nora N. , Chiara Sugrue , Wasserman Patricia 
Published: February 2015

BackgroundDiagnostic evaluation of thyroid nodules by FNA is used in the clinical management triage based on the knowledge of the rate of malignancy of each diagnostic category. The Bethesda System for Reporting Thyroid Cytopathology was published in 2007 by the National Cancer Institute (NCI). Using this classification, we studied our institution's experience in the pediatric population calculating the rate of malignancy for each diagnostic category, comparing our findings to our general patient population and that of the literature.Methods13,312 thyroid FNAs were performed at our institution between 1998 and 2010. 282 cases were from patients under 19 years of age. We reviewed and reclassified these cases using the new NCI categories, and pursued cytology‐surgical follow‐up.ResultsOf the 282 FNA cases, 20.92% (59) were classified as unsatisfactory (U), 48.22, % (136) benign (B), 2.12% (6) Atypia of undetermined significance (AUS), 14.18% (40) suspicious for follicular neoplasm (FN), 2.12% (6) suspicious for malignancy (SM) and 12.41% (35) positive for malignancy (P). The U‐category was further classified into nondiagnostic (ND) 12.41% (35) and cysts (C) 8.51% (24). Seventy‐four children had surgical follow‐up. The rates of histologically confirmed malignancy were 10% in U (1/10), 0% in B (0/17), 50% in AUS (2/4), 39% in FN (7/18), 100% in SM (4/4) and 100% in P (24/24) categories respectively. Among the U category, malignancy rate was 0% for the ND category and 25% for the C category.ConclusionsTo our knowledge, this is the first study to apply the NCI categories to the pediatric population. The rate of malignancy in the U category was only seen in the specimens with cystic component. AUS and FN categories had a higher malignancy rate (50 and 39% respectively) as compared with that of the general population (15 and 30% respectively). Given that the rates of malignancy are higher for cysts and AUS, the literature recommendation to “follow‐up and repeat” may not apply to the pediatric population. Surgery may be reasonable in these categories instead. Diagn. Cytopathol. 2015;43:598‐604. © 2015 Wiley Periodicals, Inc.
Reduced evapotranspiration from leaf beetle induced tamarisk defoliation in the Lower Virgin River using satellite‐based energy balance
Authors: Liebert Ryan , Huntington Justin , Morton Charles , Sueki Sachiko , Acharya Kumud 
Published: February 2015

AbstractTamarisk (Tamarix spp.) is an invasive shrubby tree native to Eurasia. Since its introduction to the United States, it has established itself along Southwestern American riparian systems. Control programs aimed at removing tamarisk were initiated in an effort to restore riparian areas, and potentially salvage water. Biological control of tamarisk with the Diorhabda spp. (leaf beetles) defoliates tamarisk and reduces evapotranspiration (ET). In 2009, the beetle arrived at Mesquite, Nevada, along the Virgin River, and dispersed to the Lower Virgin River riparian area in 2011. This study estimates reduced Lower Virgin River riparian ET caused by leaf beetle activity. Multi‐temporal spectral angle mapper was used to detect established leaf beetle communities in the Lower Virgin River riparian area. The Mapping Evapotranspiration at High Resolution with Internal Calibration (METRIC) land surface energy balance model was used to estimate Lower Virgin River riparian ET. METRIC ET results were compared with eddy covariance ET estimates made in tamarisk along the Lower Virgin River. Comparisons indicated that METRIC accurately estimates pre‐beetle ET and post‐beetle reduced ET. The 2007–2010 (pre‐beetle) average ET for the Lower Virgin River riparian area was 1245 mm/yr compared with 1041 mm/yr for the 2011–2012 (post‐beetle) period. Given the 4700 acre riparian area, leaf beetle induced defoliation results in a mean annual ET reduction of 3161 acre‐ft. In 2011 and 2012, volumetric reductions to ET were estimated to be 817 and 5505 acre‐ft, respectively. The METRIC model was shown to be a useful tool for monitoring ET during pre‐beetle and post‐beetle defoliation periods. Copyright © 2015 John Wiley & Sons, Ltd.
Amine‐bis(phenolato)cobalt(II) Catalysts for the Formation of Organic Carbonates from Carbon Dioxide and Epoxides
Authors: Reiter Marina , Altenbuchner Peter T. , Kissling Stefan , Herdtweck Eberhardt , Rieger Bernhard 
Published: February 2015

AbstractNew monometallic amine‐bis(phenolato)cobalt(II) [(ONNO)RCoII] (R = CMe2Ph; Cl; Br) complexes have been synthesized and fully characterized including X‐ray crystallographic analysis. These CoII complexes show good activity for the formation of cyclic propylene carbonate in combination with tetrabutylammonium bromide (TBAB) as a co‐catalyst. The reaction parameters such as carbon dioxide pressure, co‐catalyst loadings and temperature were varied to determine the ideal reaction conditions. These catalysts were also employed in copolymerization reactions of cyclohexene oxide/CO2 and propylene oxide/CO2. [(ONNO)ClCoII]*(MeOH) was found to effectively copolymerize cyclohexene oxide (CHO) and CO2. This is the first reported amine‐bis(phenolato) cobalt(II) complex to be active in the copolymerization of CO2 and CHO. In‐depth stability studies were conducted (Evan's method) to validate CoII as the active species required for copolymerization. End‐group analysis via NMR, ESI‐MS and MALDI‐TOF revealed the presence of 4‐(dimethylamino)pyridine (DMAP) and methoxy terminated chains.