bluuebunny/crossref_metadata_2025_split huggingface dataset:
More severe parotid gland histopathology in paediatric-onset than in adult-onset Sjögren’s disease
Authors: Legger Geertje Elizabeth , Nakshbandi Uzma , van Ginkel Martha S , Liefers Silvia C , de Wolff Lisette , Stel Alja J , Armbrust Wineke , Spijkervet Fred K L , Vissink Arjan , Arends Suzanne , Bootsma Hendrika , van der Vegt Bert , Verstappen Gwenny M , Kroese Frans G M 
Published: August 2024

ObjectivesThe aim of this study was to assess the histopathological features of the parotid glands in patients with paediatric-onset Sjögren’s disease (pedSjD) in comparison to patients with adult-onset Sjögren’s disease (adSjD).MethodsThis study was performed in Groningen, the Netherlands. Patients with pedSjD from a diagnostic paediatric cohort (n=19), patients with adSjD from a diagnostic adult cohort (n=32) and patients with adSjD who participated in a clinical trial (n=42) with a baseline parotid gland biopsy were included. Parotid gland biopsies were analysed after (immuno)histological staining for SjD-related histopathological markers and compared between groups.ResultsAll characteristic histopathological features of adSjD were also observed in pedSjD. There were no significant differences in lymphoepithelial lesions or immunoglobulin A (IgA)/IgG plasma cell shift between the pedSjD and the adSjD cohorts. However, compared with the diagnostic adSjD cohort (with comparable total EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI) scores), pedSjD showed more severe lymphocytic infiltration as reflected by a higher focus score (p=0.003), a higher relative surface area of CD45+ infiltrate (p=0.041), higher numbers of B and T lymphocytes/mm2(p=0.004 and p=0.029, respectively), a higher B/T lymphocyte ratio (p=0.013), higher numbers of CD21+ follicular dendritic cell networks/mm2(p=0.029) and germinal centres (GC)/mm2(p=0.002). Compared with the trial adSjD cohort, with significant higher total ESSDAI scores (p=0.001), only the B/T lymphocyte ratio and numbers of GC/mm2were significantly higher in the pedSjD cohort (p=0.023 and p=0.018, respectively).ConclusionPatients with pedSjD exhibit more pronounced histopathological features compared with patients with adSjD at diagnosis. Notably, the histopathology of patients with pedSjD aligns more closely with that observed in an adSjD clinical trial cohort, with even stronger B lymphocyte involvement.
Phase transitions and thermodynamic cycles in the broken PT-regime
Authors: Fring Andreas , Reboiro Marta 
Published: August 2024

AbstractWe propose a new type of quantum thermodynamic cycle whose efficiency is greater than the one of the classical Carnot cycle for the same conditions for a system when viewed as homogeneous. In our model, this type of cycle only exists in the low-temperature regime in the spontaneously broken parity-time-reversal (PT) symmetry regime of a non-Hermitian quantum theory and does not manifest in the PT-symmetric regime. We discuss this effect for an ensemble based on a model of a single boson coupled in a non-Hermitian way to a bath of different types of bosons with and without a time-dependent boundary. The cycle cannot be set up when considering our system as heterogeneous, i.e. undergoing a first-order phase transition. Within that interpretation, we find that the entropy is vanishing throughout the spontaneously broken PT-regime.
Controlling Oxygen Vacancy Content by Varying Calcination Temperature to Enhance the Gas Sensing Performance of BiVO4 Material
Authors: Jiao Si-Qi , Liu Yu-Feng , Zheng Xiao-Hong , Zhang Cheng , Wang Xiao-Rui 
Published: August 2024

Compared to gas sensors based on single metal oxide, gas sensors based on binary metal oxide semiconductors (MOS) offer a rich variety of structural types and hold great potential for excellent selectivity. Inspired by this, we synthesized BiVO4 powder through a stepwise reaction combining calcination with hydrothermal bath and investigated the influence of different calcination temperatures on its gas sensitivity performance. Our study revealed that BiVO4-600 exhibited optimal TEA gas sensing behavior at 225 °C, showing high response values (Ra/Rg = 43.4) and fast response/recovery times (15 s/52 s). Additionally, the sensor displayed high stability, repeatability, and exceptional selectivity. Preliminary research indicates that calcination temperature induces changes in the oxygen vacancy content of BiVO4, thus affecting its sensing performance.
Child Immunization Coverage in Urban Settings of Twelve Provinces Plus Kabul, Afghanistan, 2019
Authors: Saeed Khwaja Mir Islam , Naeemi Shoaib , Naser Ruqia , Rasooly Bahara , Hakim Mir Salamuddin , Arman Khalid , Nishat Homeira 
Published: August 2024

Background: Low immunization and discrepancies in data sources have been a consistent challenge in Afghanistan. The objective of this was to estimate the coverage of immunization status among children of 12–23 months in urban settings of 12 provinces plus Kabul, Afghanistan in 2019.Methods: A cross‐sectional survey was conducted in the capital of 12 cities of polio high‐risk provinces plus Kabul during October–December 2019. A two‐stage cluster sampling was used to approach 30 clusters and interview seven households. The coverage for 13 vaccines against 10 childhood diseases prioritized by the Afghanistan Immunization program was assessed through observation of vaccine cards or by history from caregivers of children. Epi Info v.7.2.5 was used for data management and analysis.Results: Totally, 3382 caregivers of children aged 12–23 months, of whom 50.8% were boys, were interviewed. The literacy of mothers was 35%, and 86.4% were housewives with no formal employment. The average age of children was 17.07 ± 4.05 months. In total, 1261 (37.29%) children were fully vaccinated, 833 (54.2%) were partially vaccinated, and 288 (8.52%) did not receive any dose of routine vaccine. Of total, 71.82% had vaccination cards, 17.24% had lost them, and 11% had no cards. Generally, coverage of immunization by cards and history was 91.70% for BCG, 52% for Penta, 78% for OPV‐4, 63% for PCV2, 61% for Rota2, 68.50% for measles 1, and 58% for IPV. Nangarhar and Kunar provinces have the highest and lowest immunization coverage, respectively. Lack of awareness and time was the main factor cited by partially vaccinated individuals, while misconceptions about vaccines were reported among the unvaccinated.Conclusion: Child immunization levels, varying across cities, were suboptimal in the study population. Realistic goal‐setting and awareness campaigns are necessary to address the low immunization coverage and fight against barriers in Afghanistan.
Extreme weather event causes the death of White-collared Swift Streptoprocne zonaris (Shaw, 1796) (Aves, Apodidae) individuals in sinkholes in the State of Goiás, Brazil
Authors: Andrade Maurício Carlos Martins de , Nogueira Lauana Costa , Reino José Carlos Ribeiro , Merisse Raoni Japiassu , Vicente Mariana Canutti Mariano , De-Carvalho Mariana 
Published: August 2024

The use of caves and rocky walls is common for some birds, like swifts, to shelter, sleep, nest, feed, and protect themselves from predators, wind, and rain. Several environmental and ecological factors associated with the habits and adaptations of certain species allow birds to use cave environments. The White-collared Swift Streptoprocne zonaris (Shaw, 1796) is distributed from Mexico and the Antilles south to northern Argentina, Paraguay, and southern Brazill, being frequent in areas with waterfalls and river rapids with rocky beds and crystal-clear water. Individuals live in flocks and have the habit of roosting and nesting in damp, dark caves or behind waterfalls. Herein, we aim to report the case and identify the cause of death of S. zonaris individuals found dead in a sinkhole in the State of Goiás, Brazil, in 2020. Global warming resulting from anthropogenic emissions of greenhouse gases can alter the natural fluctuations of atmospheric circulation systems, responsible for rainfall distribution, substantially affecting rainfall and increasing the frequency of heavy rainfall events in some locations. Due to climate change and the increasing frequency of flooding records, we have raised the hypothesis and drawn attention to our record may have been originated due to these climatic events. However, we do not dismiss the hypothesis that the flooding may be due to an extreme event. The fact that S. zonaris spends the night and nests close to water bodies makes the species more susceptible to the effects of a flash flood. Further studies will be able to show the real effects of global warming on the species.
Redescription of the male of Pelecorhynchus vulpes (Macquart) and first description of the male terminalia (Diptera: Pelecorhynchidae)
Authors: González Christian R. 
Published: August 2024

Macquart (1850) provided the original description of Pelecorhynchus vulpes (= Pangonia vulpes) based on a holotype male from Chile. His description is brief and lacks many morphological details. Therefore, herein we redescribe, in far greater detail, the holotype male of Pelecorhynchus vulpes (Macquart) and describe and illustrate, for the first time, the morphology of the male terminalia.
Direct Entrainment as a Measure of Dilution
Authors: Oh Gunho (Loren) , Austin Philip H. 
Published: August 2024

Abstract
The turbulent transport of mass, energy, moisture, and momentum between the clouds and the surrounding environment plays a central role in determining the vertical structure of the troposphere. This article investigates the connection between net entrainment, defined here as the net transport of air into individual clouds, and net dilution, defined as the tendencies of passive tracers such as static energy or total water mixing ratio. Entrainment and detrainment rates for 2.6 × 106 individual cloud samples are obtained from a large-eddy simulation of shallow convective boundary layer atmosphere that explicitly calculates the turbulent fluxes across the cloud boundaries. The equations describing the tendencies of cloud mass and tracer concentrations are derived as a function of directly calculated entrainment and detrainment rates of the individual clouds, and used to calculate net entrainment and dilution rates. Directly calculated net entrainment and dilution rates agree well with cloud mass and tracer tendencies and give a dilution time scale of 13 min. In contrast, the traditional bulk-plume approximation overestimates the effect of entrainment and detrainment on the dilution of cloud field properties due to the differential tracer transport through the moist shell surrounding the cloud. Using direct measures of entrainment and detrainment for individual clouds separates different processes that influence the turbulent mass transport between the clouds and their environment.
Ulinastatin shortens the length of ICU stay in critical patients with organ failure: A 7-year real-world study
Authors: Wu Lixue , Xu Deduo , Liu Yanru , Li Wenfang , Jiang Weiwei , Tao Xia , Zhang Jinyuan , Yu Ze , Gao Fei , Chen Wansheng , Lin Zhaofen , Shan Yi 
Published: August 2024

Background: Ulinastatin has been applied in a series of diseases associated with inflammation but its clinical effects remain somewhat elusive. Objective: We aimed to investigate the potential effects of ulinastatin on organ failure patients admitted to the intensive care unit (ICU). Methods: This is a single-center retrospective study on organ failure patients from 2013 to 2019. Patients were divided into two groups according to using ulinastatin or not during hospitalization. Propensity score matching was applied to reduce bias. The outcomes of interest were 28-day all-cause mortality, length of ICU stay, and mechanical ventilation duration. Results: Of the 841 patients who fulfilled the entry criteria, 247 received ulinastatin. A propensity-matched cohort of 608 patients was created. No significant differences in 28-day mortality between the two groups. Sequential organ failure assessment (SOFA) was identified as the independent risk factor associated with mortality. In the subgroup with SOFA ≤ 10, patients received ulinastatin experienced significantly shorter time in ICU (10.0 d [interquartile range, IQR: 7.0∼20.0] vs 15.0 d [IQR: 7.0∼25.0]; p = .004) and on mechanical ventilation (222 h [IQR:114∼349] vs 251 h [IQR: 123∼499]; P = .01), but the 28-day mortality revealed no obvious difference (10.5% vs 9.4%; p = .74). Conclusion: Ulinastatin was beneficial in treating patients in ICU with organ failure, mainly by reducing the length of ICU stay and duration of mechanical ventilation.
The impact of stent protrusion into the inferior vena cava or jailing of the contralateral iliac vein on the incidence of contralateral deep vein thrombosis following venous stenting
Authors: Nguyen Duy , Pappas Karl , Mahadevan Shreya , Sulakvelidze Levan , Kennedy Richard , Lakhanpal Gaurav , Lakhanpal Sanjiv , Pappas Peter J 
Published: August 2024

Objective Iliac vein stenting is the standard of care for patients with pelvic venous disorders secondary to symptomatic iliac vein outflow obstruction. Venous stents are often extended proximally into the inferior vena cava (IVC) which may result in partial or complete coverage of the contralateral iliac vein. The purpose of this investigation is to determine if extension of iliac vein stents into the IVC results in increased risk of contralateral deep venous thrombosis (DVT). Methods We retrospectively reviewed prospectively collected data from 409 patients who underwent iliac vein stenting at the Center for Vascular Medicine (CVM) from 2019 to 2020. Stent type, covered territories, initial and follow-up consults, ultrasound and operative reports were reviewed to assess for incidence of post-implantation DVT. Patients were stratified into three groups: Iliac vein stents which protruded into the IVC, stents that completely covered the orifice of the contralateral iliac vein and those with no stent protrusion into the IVC. Results Out of 409 patients, the average age was 53.96 ± 13.40 years with 94 males and 315 females. All stents placed were Venovo stents and all iliac vein lesions were non-thrombotic stenoses. The average follow-up period was 14.35 ± 10.09 months. The most common territories stented were the IVC-LCIV-LEIV ( n = , 74%) and the IVC-RCIV-REIV ( n = , 26%). Stent protrusion and distance into the IVC in millimeters (mm) was the following: Partial protrusion ( n = 314, 77%, 27.6 ± 19.1), jailing of the contralateral iliac vein ( n = 78, 19%, 45.9 ± 18.6), no protrusion ( n = 16, 4%). The overall DVT rate post-implantation was 0.49% ( n = 2). No DVTs ipsilateral to the index stent were identified and both DVTs were contralateral DVTs. A hypercoaguable disorder was reported in 6 patients (1.5%). There were no significant differences in prevalence of contralateral DVT between the three groups. ( p = .35). Conclusion The rate of contralateral DVTs post iliac vein stenting with Nitonol based stents is extremely low. Partial or complete coverage of the contralateral iliac vein via stenting does not result in an increased incidence of contralateral DVT in the short-term. Longer follow up is needed to determine if contralateral DVTs occur after long-term implantation.
Prenatal Cannabis and Tobacco Co-Exposure and Its Association with Behavioural Outcomes in Middle Childhood: Co-exposition prénatale au cannabis et au tabac et son association avec les résultats comportementaux au cours de l'enfance intermédiaire
Authors: Nadler Emma , Jacobus Joanna , Rabin Rachel A. 
Published: August 2024

Objectives Cannabis legalization has triggered an increase in prenatal cannabis use. Given that tobacco is commonly co-used with cannabis, determining outcomes associated with prenatal cannabis and tobacco co-exposure is crucial. While literature exists regarding the individual effects of prenatal cannabis and tobacco exposure on childhood behaviour, there is a gap regarding their combined use, which may have interactive effects. Therefore, we investigated whether prenatal cannabis and tobacco co-exposure was associated with greater externalizing and internalizing problems in middle childhood compared to prenatal exposure to either substance alone or no exposure. Methods Baseline data from the Adolescent Brain Cognitive Development (ABCD) Study (collected in children ages 9–11) were used to explore differences in externalizing and internalizing scores derived from the Childhood Behavior Checklist across four groups: children with prenatal cannabis and tobacco co-exposure (CT, n = 290), children with prenatal cannabis-only exposure (CAN, n = 225), children with prenatal tobacco-only exposure (TOB, n = 966), and unexposed children (CTL, n = 8,311). We also examined if the daily quantity of tobacco exposure modulated the effect of cannabis exposure on outcomes. Results Adjusting for covariates, a 2 × 2 ANCOVA revealed significant main effects for prenatal cannabis ( p = 0.03) and tobacco exposure ( p < 0.001), and a significant interaction effect on externalizing scores ( p = 0.032); no significant main effects or interactions were found for internalizing scores. However, interactions between daily quantity of cannabis and tobacco exposure significantly predicted both externalizing and internalizing scores ( p < 0.01). Conclusions These findings indicate that co-exposure is associated with greater externalizing problems than exposure to either substance alone, which did not differ from each other. Further, greater tobacco exposure may amplify the negative effect of cannabis exposure on both externalizing and internalizing behaviours in children. These findings underscore the need for interventions that target cannabis and tobacco co-use in pregnant women to circumvent their adverse impact on middle childhood behaviour. Plain Language Summary Title Prenatal Cannabis and Tobacco Co-exposure and its Association with Middle Childhood Behaviours
Chronic aluminium chloride exposure induces redox imbalance, metabolic distress, DNA damage, and histopathologic alterations in Wistar rat liver
Authors: Shahabuddin Farha , Naseem Samina , Alam Tauseef , Khan Aijaz Ahmed , Khan Farah 
Published: August 2024

Aluminium, a ubiquitous environmental toxicant, is distinguished for eliciting a broad range of physiological, biochemical, and behavioural alterations in laboratory animals and humans. The present work was conducted to study the functional and structural changes induced by aluminium in rat liver. Twenty five adult male Wistar rats (150–200 g) were randomly divided into five groups; control group and four Al-treated groups viz: Al 1 (25 mg AlCl3/kg b.wt), Al 2 (35 mg AlCl3/kg b.wt), Al 3 (45 mg AlCl3/kg b.wt), and Al 4 (55 mg AlCl3/kg b.wt). Rats in the aluminium-treated groups were administered AlCl3 for 30 days through oral gavage. Aluminium significantly increased the serum levels of liver function markers (ALT, AST, and ALP), phospholipids, and cholesterol. The activities of hepatocyte membrane (ALP, GGT, and LAP) and carbohydrate metabolic (G6P, F16BP, HK, LDH, MDH, ME, and G6PDH) enzymes were significantly altered by AlCl3 administration. Prolonged Al exposure induced oxidative stress in the liver, as evident by significant hepatocellular DNA damage, increased lipid peroxidation, and decreased non-enzymatic and enzymatic antioxidants. The toxic effects observed in this study were AlCl3 dose-dependent. Histopathological examination of liver sections revealed enlargement of sinusoidal spaces, derangement of the hepatic chord, loss of discrete hepatic cell boundaries, congestion of hepatic sinusoids, and degeneration of hepatocytes in Al-intoxicated rats. In conclusion, aluminium causes severe hepatotoxicity by inhibiting the hepatocyte membrane enzymes and disrupting the liver’s energy metabolism and antioxidant defence.
Palliative Care Experiences Among Adults From Underrepresented Racial and Ethnic Groups in the United States: A Scoping Review
Authors: Oduro Elisha Baafi , Jackson Amy , Fu Yunting , Carpenter Joan G. 
Published: August 2024

Background Patients from underrepresented racial and ethnic groups (URGs) in the United States (US) experience disparities in accessing palliative care (PC) at the end of life (EOL). Additionally, little effort has been made to understand their experiences with PC. Objectives To identify and synthesize existing literature on PC experiences among adults from URGs in nursing homes, community settings, and hospitals in the US. Methods Guided by the Joanna Briggs Institute methodological recommendation and Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews, we conducted a scoping review. We searched PubMed, EMBASE, CINAHL, Scopus, and ProQuest Dissertations & Theses Global from inception to January 2024. Results We included five studies representing Hispanic/Latino, American Indian, African/Black American, and Chinese individuals. Data were organized around two themes: navigating PC pathway and choices and practices during PC. Navigating PC pathway theme highlights that despite the several barriers URGs face when accessing PC, they seek PC services due to their limited formal family assistance in managing their chronic conditions and pain. The choices and practices during PC theme emphasize the roles URG family members play in EOL care, the patient’s care preferences, and their spiritual practices and beliefs related to EOL care. Conclusion This scoping review reveals limited literature about URG experiences with PC and highlights the need for more studies to focus on making PC services more accessible to URGs and providing culturally sensitive care to meet the needs of the diverse growing US population.
Aerobic Training and Ointment Effect on range of motion, von Willebrand factor, vascular endothelial factor and Femoral Artery Hemodynamics in Joint Contracture: A Rat Model
Authors: Maimaiti Palida , Shu Jiaojiao , Miao Tianyu , Keqike Nuerbiya , Tuersun Asiguli , Ruiqi Yang  , Wang Ningning 
Published: August 2024

Objective Using a rat model, we investigated the effect of multidisciplinary rehabilitation, including aerobic training and ointment, on the ROM, vWF, VEGF content, and femoral artery hemodynamics in rats with joint contracture. Methods A total of 44 Wistar rats were divided into the normal control group (NC, eight rats) and the experimental group (EG). A joint contracture model was established for the rats in the EG group by an external fixator. After fixator removal, 32 rats are further divided into the MC, SC, RE, and SR groups ( n = 8). Before and after the 42 day intervention, the ROM, vWF, VEGF, PS, ED, and RI were measured using X-ray imaging, ELISA, and color Doppler ultrasound, respectively. Results After fixator removal, ROM for EG group was lower than that of the NC group ( p < .01). After the intervention, ROM for the SR, RE, and SC groups was improved. The ROM for the SR group reached a similar value for NC group. vWF and VEGF levels in SR group were lower than in the MC, SC, and RE groups ( p < .05), and had a similar value to the NC groups. PS value for SR and RE groups was higher than the MC and SC groups. The RI value for SR group was higher than that of NC and MC groups. Conclusion Multidisciplinary rehabilitation used in this study can treat joint contracture synergistically. It improves the ROM of the joint, reduces the content of vWF and VEGF, and improves the femoral artery hemodynamics.