bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiethnic Perspectives of Shared Decision‐Making in Hypertension: A Mixed‐Methods Study
Authors: Elias Sabrina , Wenzel Jennifer , Cooper Lisa A. , Perrin Nancy , Commodore‐Mensah Yvonne , Lewis Krystina B. , Koirala Binu , Slone Sarah , Byiringiro Samuel , Marsteller Jill , Himmelfarb Cheryl R. , Marsteller Jill A. , Ahima Rexford , Alvarez Carmen , Antoine Denis G. , Avornu Gideon , Bhattarai Jagriti , Bone Lee , Boonyasai Romsai T. , Carson Kathryn A. , Charleston Jeanne , Chung Suna , Cort Marcia , Crews Deidra C. , Daumit Gail L. , Dietz Katherine B. , Eyer Teresa , Frazier Demetrius , Greer Raquel , Hickman Debra , Hill‐Briggs Felicia , Dennison Himmelfarb Cheryl R. , Hines Anika , Hull Tammie , Ibe Chidinma A. , Johnson Lawrence , Johnson Susan , Kargbo Mary , Kelleher Mary , Lazo Mariana , Lubomski Lisa , Mathews Lena M. , Miller Edgar R. , Ndumele Chiadi E. , Turkson‐Ocran Ruth‐Alma , Parker Randy , Peterson Cassandra , Purnell Tanjala S. , Spicyn Natalie , Teagle DeNotta , Wang Nae‐Yuh , White Marcee , Yeh Hsin‐Chieh , Young Joan , Zeren Kimberly L. 
Published: July 2024

Background
Shared decision‐making (SDM) has the potential to improve hypertension care quality and equity. However, research lacks diverse representation and evidence about how race and ethnicity affect SDM. Therefore, this study aims to explore SDM in the context of hypertension management.

Methods and Results

Explanatory sequential mixed‐methods design was used. Quantitative data were sourced at baseline and 12‐month follow up from RICH LIFE (Reducing Inequities in Care of Hypertension: Lifestyle Improvement for Everyone) participants (n=1212) with hypertension. Qualitative data were collected from semistructured individual interviews, at 12‐month follow‐up, with participants (n=36) selected based on their SDM scores and blood pressure outcome. Patients were cross‐ categorized based on high or low SDM scores and systolic blood pressure reduction of ≥10 or <10 mm Hg. Multinomial logistic regression analysis showed that predictors of SDM scores and blood pressure outcome were race and ethnicity (relative risk ratio [RRR], 1.64;
P
=0.029), age (RRR, 1.03;
P
=0.002), educational level (RRR, 1.87;
P
=0.016), patient activation (RRR, 0.98;
P
<0.001; RRR, 0.99;
P
=0.039), and hypertension knowledge (RRR, 2.2;
P
<0.001; and RRR, 1.57;
P
=0.045). Qualitative and mixed‐methods findings highlight that provider–patient communication and relationship influenced SDM, being emphasized both as facilitators and barriers. Other facilitators were patients' understanding of hypertension; clinicians' interest in the patient, and clinicians' personality and attitudes; and barriers included perceived lack of compassion, relationship hierarchy, and time constraints.

Conclusions
Participants with different SDM scores and blood pressure outcomes varied in determinants of decision and descriptions of contextual factors influencing SDM. Results provide actionable information, are novel, and expand our understanding of factors influencing SDM in hypertension.
Building and Breaking the Chain: A Model of Reward Prediction Error Integration and Segmentation of Memory
Authors: Rouhani Nina , Clewett David , Antony James W. 
Published: July 2024

Abstract
Prediction errors drive reinforcement learning and organize episodic memory into distinct contexts, but do these effects interact? Here, we review the roles of midbrain dopamine, the locus coeruleus, and the hippocampus in event cognition to propose and simulate the theoretical influence of two prediction error signals in integrating versus segmenting events in memory. We suggest that signed reward prediction errors can build mental models of reward environments, increasing the contextual similarity (integration) of experiences with stronger, more stable reward expectations. On the other hand, unsigned reward prediction errors can signal a new model of the environment, generating a contextual shift (segmentation) between experiences that crossed them. We moreover predicted that these differences in contextual similarity give rise to distinct patterns of temporal-order memory. We combined these ideas in a computational model to account for a seemingly paradoxical pattern of temporal-order memory where greater representational distance helps order memory within context but impairs it across contexts. We found that simulating signed reward prediction error integration and unsigned reward prediction error segmentation differentially enabled the model to perform associative chaining, which involved reactivating items between two tested probes to assist with sequential retrieval. In summary, our simulations provide a unifying explanation for the varied ways that neuromodulatory systems may alter event cognition and memory.
Is That You I Hear? Speaker Familiarity Modulates Neural Signatures of Lexical-semantic Activation in 18-month-old Infants
Authors: Montgomery Clarissa , Guellaï Bahia , Rämä Pia 
Published: July 2024

Abstract
Developmental language studies have shown that lexical-semantic organization develops between 18 and 24 months of age in monolingual infants. In the present study, we aimed to examine whether voice familiarity facilitates lexical-semantic activation in the infant brain. We recorded the brain activity of 18-month-old, French-learning infants using EEG while they listened to taxonomically related and unrelated spoken word pairs by one voice with which they were familiarized with before the experiment, and one voice with which they were not familiarized. The ERPs were measured in response to related and unrelated target words. Our results showed an N400 effect (greater amplitudes for unrelated as opposed to related target words) over the left hemisphere, only for the familiar voice, suggesting that the voice familiarity facilitated lexical-semantic activation. For unfamiliar voices, we observed an earlier congruence effect (greater amplitudes for related than for unrelated target words). This suggests that although 18-month-olds process lexical-semantic information from unfamiliar speakers, their neural signatures of lexical-semantic processing are less mature. Our results show that even in the absence of personal relation with a speaker, familiarity with a voice augments infant lexical-semantic processing. This supports the idea that extralinguistic information plays a role in infant lexical-semantic activation.
Musical Expertise Influences the Processing of Short and Long Auditory Time Intervals: An Electroencephalography Study
Authors: Thibault Nicola , D'amours Stéphanie , Albouy Philippe , Grondin Simon 
Published: July 2024

AbstractMusical expertise has been proven to be beneficial for time perception abilities, with musicians outperforming nonmusicians in several explicit timing tasks. However, it is unclear how musical expertise impacts implicit time perception. Twenty nonmusicians and 15 expert musicians participated in an EEG recording during a passive auditory oddball paradigm with 0.8- and 1.6-sec standard time intervals and deviant intervals that were either played earlier or delayed relative to the standard interval. We first confirmed that, as was the case for nonmusicians, musicians use different neurofunctional processes to support the perception of short (below 1.2 sec) and long (above 1.2 sec) time intervals: Whereas deviance detection for long intervals elicited a N1 component, P2 was associated with deviance detection for short time intervals. Interestingly, musicians did not elicit a contingent negative variation (CNV) for longer intervals but show additional components of deviance detection such as (i) an attention-related N1 component, even for deviants occurring during short intervals; (ii) a N2 component for above and below 1.2-sec deviance detection, and (iii) a P2 component for above 1.2-sec deviance detection. We propose that the N2 component is a marker of explicit deviance detection and acts as an inhibitory/conflict monitoring of the deviance. This hypothesis was supported by a positive correlation between CNV and N2 amplitudes: The CNV reflects the temporal accumulator and can predict explicit detection of the deviance. In expert musicians, a N2 component is observable without CNV, suggesting that deviance detection is optimized and does not require the temporal accumulator. Overall, this study suggests that musical expertise is associated with optimized implicit time perception.
Goal Shifts Structure Memories and Prioritize Event-defining Information in Memory
Authors: Cowan Emily T. , Chanales Avi J. , Davachi Lila , Clewett David 
Published: July 2024

Abstract
Every day, we encounter far more information than we could possibly remember. Thus, our memory systems must organize and prioritize the details from an experience that can adaptively guide the storage and retrieval of specific episodic events. Prior work has shown that shifts in internal goal states can function as event boundaries, chunking experiences into distinct and memorable episodes. In addition, at short delays, memory for contextual information at boundaries has been shown to be enhanced compared with items within each event. However, it remains unclear if these memory enhancements are limited to features that signal a meaningful transition between events. To determine how changes in dynamic goal states influence the organization and content of long-term memory, we designed a 2-day experiment in which participants viewed a series of black-and-white objects surrounded by a color border on a two-by-two grid. The location of the object on the grid determined which of two tasks participants performed on a given trial. To examine if distinct types of goal shifts modulate the effects of event segmentation, we changed the border color, the task, or both after every four items in a sequence. We found that goal shifts influenced temporal memory in a manner consistent with the formation of distinct events. However, for subjective memory representations in particular, these effects differed by the type of event boundary. Furthermore, to examine if goal shifts lead to the prioritization of goal-relevant features in longer lasting memories, we tested source memory for each object's color and grid location both immediately and after a 24-hr delay. On the immediate test, boundaries enhanced the memory for all concurrent source features compared with nonboundary items, but only if those boundaries involved a goal shift. In contrast, after a delay, the source memory was selectively enhanced for the feature relevant to the goal shift. These findings suggest that goals can adaptively structure memories by prioritizing contextual features that define a unique episode in memory.
Precipitation Proxies for Flash Flooding: A Seven-Year Analysis over the Contiguous United States
Authors: James Eric P. , Schumacher Russ S. 
Published: July 2024

Abstract
Flash flooding remains a challenging prediction problem, which is exacerbated by the lack of a universally accepted definition of the phenomenon. In this article, we extend prior analysis to examine the correspondence of various combinations of quantitative precipitation estimates (QPEs) and precipitation thresholds to observed occurrences of flash floods, additionally considering short-term quantitative precipitation forecasts from a convection-allowing model. Consistent with previous studies, there is large variability between QPE datasets in the frequency of “heavy” precipitation events. There is also large regional variability in the best thresholds for correspondence with reported flash floods. In general, flash flood guidance (FFG) exceedances provide the best correspondence with observed flash floods, although the best correspondence is often found for exceedances of ratios of FFG above or below unity. In the interior western United States, NOAA Atlas 14 derived recurrence interval thresholds (for the southwestern United States) and static thresholds (for the northern and central Rockies) provide better correspondence. The 6-h QPE provides better correspondence with observed flash floods than 1-h QPE in all regions except the West Coast and southwestern United States. Exceedances of precipitation thresholds in forecasts from the operational High-Resolution Rapid Refresh (HRRR) generally do not correspond with observed flash flood events as well as QPE datasets, but they outperform QPE datasets in some regions of complex terrain and sparse observational coverage such as the southwestern United States. These results can provide context for forecasters seeking to identify potential flash flood events based on QPE or forecast-based exceedances of precipitation thresholds.
Significance Statement
Flash floods result from heavy rainfall, but it is difficult to know exactly how much rain will cause a flash flood in a particular location. Furthermore, different precipitation datasets can show very different amounts of precipitation, even from the same storm. This study examines how well different precipitation datasets and model forecasts, used by forecasters to warn the public of flash flooding, represent heavy rainfall leading to flash flooding around the United States. We found that different datasets have dramatically different numbers of heavy rainfall events and that high-resolution model forecasts of heavy rain correspond with observed flash flood events about as well as precipitation datasets based on rain gauge and radar in some regions of the country with few observations.
Evaluation of Noah-MP Snow Simulation across Site Conditions in the Western United States
Authors: von Kaenel Manon , Margulis Steven A. 
Published: July 2024

Abstract
Quantifying spatiotemporal variability in snow water resources is a challenge especially relevant for regions that rely on snowmelt for water supply. Model accuracy is often limited by uncertainties in meteorological forcings and/or suboptimal physics representation. In this study, we evaluate the performance and sensitivity of Noah land surface model with multiparameterization options (Noah-MP) snow simulations from ten model configurations across 199 sites in the western United States. Nine experiments are constrained by observed meteorology to test snow-related physics options, and the 10th experiment tests an alternative source of meteorological forcings. We find that the base case, which aligns with the National Water Model configuration and uses observation-based forcings, overestimates observed accumulated snow water equivalent (SWE) at 90% of stations by a median of 9.6%. The model performs better in the accumulation season at colder, drier sites and in the melt season at wetter, warmer sites. Accumulation metrics are sensitive to model configuration in two experiments, and melt metrics, in six experiments. Alterations to model physics cause changes to median accumulation metrics from −13% to 2.3% with the greatest change due to precipitation partitioning and to melt metrics from −10% to 3% with the greatest change due to surface resistance configuration. The experiment with alternative forcings causes even greater and wider-ranging changes (medians ranging from −29% to 6%). Not all stations share the same best-performing model configuration. At most stations, the base case is outperformed by four alternative physics options which also significantly impact snow simulation. This research provides insights into the performance and sensitivity of snow predictions across site conditions and model configurations.

Significance Statement
The purpose of this work is to evaluate the performance and sensitivity of a land surface model’s simulation of snow across site conditions and in response to different model configurations. This is important because estimating snow distribution is a challenge especially relevant for regions that rely on snowmelt for water supply. While land surface models can provide useful large-scale estimates, they are often limited by uncertainties in forcings and/or suboptimal physics representation. The results, which show varying model behavior across geography, climate, vegetation types, and model configurations, highlight inadequacies in model physics representation, emphasize the need for accurate meteorological forcings, and suggest that customizing model configurations to the unique characteristics of the domain could yield more accurate and useful results.
A Systematic Review of Symptoms of Pernicious Anemia
Authors: Seage Catherine Heidi , Bennett Alexis , Ward Nicola , Semedo Lenira , Plattel Clara H. M. , Suijker Kim I. M. , Vis Jolande Y. , James Delyth H. 
Published: July 2024

Background: Pernicious anemia (PA) is a type of macrocytic anemia caused by autoimmune gastritis. To facilitate timely diagnosis and treatment of PA there is a pressing need for improved understanding among Healthcare providers of the condition’s symptoms and diagnostic criteria. Objective: This systematic review aims to extend existing clinical knowledge on the presentation of PA by determining which symptoms and clinical complications are reported in published adult case studies. Methods: Relevant studies were identified through electronic searches of PsycINFO, Embase, and MEDLINE, via OvidSP. During data extraction symptoms were categorized according to the International Classification of Diseases and were grouped based on frequency. Results: Symptoms were documented for 103 adults with a diagnosis of PA; the most frequent symptoms were fatigue (55%), loss of sensation in limbs (32%), excessive weight loss (27%), and a sore tongue (23%). Conclusions: This review highlights the diverse symptomology of adults who are diagnosed with PA. Most symptoms documented in case studies are consistent with the core signs of B12 and folate deficiencies. Research is needed to identify if there are common clusters of PA symptoms that can be used as prompts for diagnostic testing in patients with suspected B12 deficiency.
Indicators of Cobalamin Status During Pregnancy, Pregnancy Outcome and Long-Term Effects on Offspring Health
Authors: Santos-Calderón Luis Adolfo , Rojas-Gómez Alejandra , Ramos-Rodríguez Carla , Murphy Michelle M. 
Published: July 2024

Background: Little attention has been given to prenatal cobalamin insufficiency in settings where dietary cobalamin intake is presumed adequate, such as populations with habitual intake of foods from animal sources. Results: However, low cobalamin status in women of fertile age has been reported in Europe, United States, and Canada. In India, where cobalamin deficiency is highly prevalent, it has been associated with an increased risk of miscarriage, intrauterine growth retardation, as well as insulin resistance and lower neurodevelopment scores in the offspring. Low cobalamin status in pregnancy has been associated with similar outcomes as those reported in the Indian studies although the evidence is scant and conflicting. Conclusions: Consideration should be given to maternal cobalamin status in the context of prevention of adverse pregnancy outcomes as well as cobalamin insufficiency both in the mother and the offspring during lactation. Further attention is now justified with the increasing tendency toward plant-based diets. Reference intervals for cobalamin status during each trimester of pregnancy are needed and further investigation of the long-term conse-quences of low cobalamin status during pregnancy for health and development in the offspring is warranted.
Excess Folic Acid and Vitamin B12 Deficiency: Clinical Implications?
Authors: Miller Joshua W. , Smith Andre , Troen Aron M. , Mason Joel B. , Jacques Paul F. , Selhub Jacob 
Published: July 2024

Background: In the 1940s to 1950s, high-dose folic acid supplements (>5 mg/d) were used clinically to reverse the megaloblastic anemia of vitamin B12 deficiency caused by pernicious anemia. However, this treatment strategy masked the underlying B12 deficiency and possibly exacerbated its neuropathological progression. The issue of masking and exacerbating B12 deficiency has recently been rekindled with the institution of folic acid fortification and the wide-spread use of folic acid supplements. Objectives: The objectives of this review are to describe clinical and epidemiological evidence that excess folic acid exacerbates B12 deficiency, to summarize a hypothesis to explain this phenomenon, and to provide guidance for clinicians. Results: Cognitive function test scores are lower and blood homocysteine and methylmalonic acid concentrations are higher in people with low B12 and elevated folate than in those with low B12 and nonelevated folate. High-dose folic acid supplementation in patients with pernicious anemia or epilepsy cause significant reductions in serum B12. It is hypothesized that high-dose folic acid supplements cause depletion of serum holotranscobalamin and thus exacerbate B12 deficiency. Conclusion: The evidence for excess folic acid exacerbating B12 deficiency is primarily correlative or from uncontrolled clinical observations, and the hypothesis to explain the phenomenon has not yet been tested. Nonetheless, the evidence is sufficiently compelling to warrant increased vigilance for identifying B12 deficiency in at risk individuals, including older adults and others with low B12 intake or conditions that are associated with B12 malabsorption, who also ingest excessive folic acid or are prescribed folic acid in high doses.
Development of a Vitamin B12 Deficiency Patient-Reported Outcome Measure for Clinical Practice and Research
Authors: Suijker Kim I. M. , Plattel Clara H. M. , Seage Catherine H. , Ward Nicola , James Delyth H. , Vis Jolande Y. 
Published: July 2024

Background: It is difficult to recognize vitamin B12 deficiency and to evaluate the effect of B12 treatment due to a broad range of variable clinical symptoms overlapping with other diseases and diagnostic biomarkers that quickly normalize during treatment. This poses a risk of delay in diagnosis and a challenge to uniformly monitor the effect of B12 treatment. There is a need for a new clinical outcome measure suitable for clinical practice and clinical evaluation studies. Objective: To develop a Patient-Reported Outcome Measure (PROM) which measures the severity of vitamin B12 deficiency symptoms. Methods: The B12 PROM was developed by (1) gathering input from experts and literature review to define a construct and develop a conceptual model, (2) processing input from health care providers, scientists, and patients to develop items and response options, and (3) improving items based on the feedback from laypersons, test interviews, semi-structured cognitive interviews with patients, and forward and backward translation (ENG-NL). Results: The B12 PROM includes 62 items grouped into 8 categories of symptoms related to vitamin B12 deficiency (General, Senses, Thinking, In limbs and/or face, Movement, Emotions, Mouth & Abdomen, Urinary tract & Reproductive organs). Cognitive interviews demonstrated good comprehensibility and comprehensiveness. Conclusions: This study is the first step in the development of a disease-specific PROM for vitamin B12 deficiency to measure the burden of symptoms. Further validation and reliability testing are necessary before the PROM can be applied in clinical practice and research.