bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of lycopene intake and consumption of tomato products to incident CVD
Authors: Jacques Paul F. , Lyass Asya , Massaro Joseph M. , Vasan Ramachandran S. , D'Agostino Sr Ralph B. 
Published: January 2013

Evidence for cardioprotective effects of lycopene is inconsistent. Studies of circulating lycopene generally report inverse associations with CVD risk, but studies based on lycopene intake do not. The failure of dietary studies to support the findings based on biomarkers may be due in part to misclassification of lycopene intakes. To address this potential misclassification, we used repeated measures of intake obtained over 10 years to characterise the relationship between lycopene intake and the incidence of CVD (n314), CHD (n171) and stroke (n99) in the Framingham Offspring Study. Hazard ratios (HR) for incident outcomes were derived from Cox proportional hazards regression models using logarithmically transformed lycopene intake adjusted for CVD risk factors and correlates of lycopene intake. HR were interpreted as the increased risk for a 2·7-fold difference in lycopene intake, a difference approximately equal to its interquartile range. Using an average of three intake measures with a 9-year follow-up, lycopene intake was inversely associated with CVD incidence (HR 0·83, 95 % CI 0·70, 0·98). Using an average of two intake measures and 11 years of follow-up, lycopene intake was inversely associated with CHD incidence (HR 0·74, 95 % CI 0·58, 0·94). Lycopene intake was unrelated to stroke incidence. The present study of lycopene intake and CVD provides supporting evidence for an inverse association between lycopene and CVD risk; however, additional research is needed to determine whether lycopene or other components of tomatoes, the major dietary source of lycopene, are responsible for the observed association.
Ageing and the prevalence and treatment of mental health problems
Authors: Jokela M. , Batty G. D. , Kivimäki M. 
Published: January 2013

BackgroundAgeing is an important factor in the development of mental health problems and their treatment. We assessed age trajectories of common mental disorders (CMDs) and psychotherapy utilization from adolescence to old age, and examined whether these trajectories were modified by time period or birth cohort effects.MethodBritish Household Panel Survey (BHPS) with an 18-year follow-up between 1991 and 2009 (n = 30 224 participants, aged 15–100 years, with an average 7.3 person-observations per person). CMDs were assessed with the 12-item version of the General Health Questionnaire (GHQ). Psychotherapy treatment utilization during the past year was self-reported by the participants. The modifying influences of time period and cohort effects were assessed in a cohort-sequential longitudinal setting.ResultsFollowing a moderate decrease after age 50, the prevalence of GHQ caseness increased steeply from age 75. This increase was more marked in the 2000s (GHQ prevalence increasing from 24% to 43%) than in the 1990s (from 22% to 34%). Psychotherapy utilization decreased after age 55, with no time period or cohort effects modifying the age trajectory. These ageing patterns were replicated in within-individual longitudinal analysis.ConclusionsOld age is associated with higher risk of CMDs, and this association has become more marked during the past two decades. Ageing is also associated with an increasing discrepancy between prevalence of mental disorders and provision of treatment, as indicated by lower use of psychotherapy in older individuals.
Supersession or Subsession? Exodus Typology, the Christian Eucharist and the Jewish Passover Meal
Authors: Boulton Matthew Myer 
Published: January 2013

AbstractContemporary Christian construals of the Eucharist, both in doctrine and in practice, generally tend to subordinate, de-emphasise or omit theological reference to the Jewish Passover meal. And yet the key New Testament texts in which the Eucharist's institution is variously narrated – the very texts and institution allegedly ‘remembered’ in eucharistic rites – are virtually unintelligible apart from Passover. Thus, at the heart of Christian doctrine and practical life sits a particular theological problem: namely, precisely how to relate the distinctively Jewish character of the Eucharist's origins as narrated in the New Testament to the distinctively Christian character of eucharistic doctrine and liturgy. Drawing on two Jewish thinkers, Michael Fishbane and Yair Zakovitch, in this article I offer one model for understanding the Eucharist–Passover relationship in particular, and the Christian–Jewish relationship generally, as fundamentally typological, performative and ‘subsessionist’. That is, I propose a subsessionist (as opposed to supersessionist) typological understanding of the Eucharist as a Christian rendition of Passover, at once distinct from its Jewish counterparts today and utterly dependent on the ancient Israelite festival for its intelligibility and force. From Fishbane, I draw the idea that throughout the Hebrew Bible, the exodus narrative provides a crucial interpretative key applicable to both prior and anticipated redemptions. From Zakovitch, I draw the idea that the ubiquity of exodus typology in Hebrew scripture may function to create an impression of periodic repetition in salvation history, in effect reassuring Israel that future deliverance will conform to the essential patterns of the prestigious past. The typology at play here, then, so far from being a triumphalist ‘prophecy-fulfilment’ arrangement in which the ‘old’ is valuable only insofar as it serves as a signpost pointing to the ‘new’, is rather a ‘paradigm-rendition’ typology in which the new performance is clarified and authenticated precisely insofar as it corresponds to the old, exalted original. At stake here, I contend, is not only a more fruitful framework for conceiving the relationship between Eucharist and Passover (or indeed between Christianity and Judaism), but also a crucial theological strategy for resisting what amounts to ade factoMarcionism in contemporary Christian communities.
‘Dignified’: An Exegetical Soteriology of Divine Honour
Authors: Borges Jason 
Published: January 2013

AbstractSocial scientists in disparate fields are now employing the construct of honour to ameliorate various social problems, such as immorality, failed states, international discord, poverty and mental illness. Moreover, historians of global religion cite Christianity's shift towards cultures shaped by the values of honour and shame. Despite this growing prominence of honour in social theories and the emergence of Christianity in honour–shame cultures, the notion of honour remains absent from theological discourse. In light of these global realities, we explore how God's active transformation of humanity from shame to honour can interpret both salvation-history and Christian theology. To this end I first explore the nature of humanity's problem of shame before God, using anthropological and biblical insights. Throughout the Old Testament, God's covenant initiatives with Abram, Moses and David, along with the common socio-literary pattern of God exalting a servant from unjust shame, reveals the dignified status God intends for humanity. God's programme to restore people from shame to honour climaxes in Jesus, who embodies honour in the incarnation, mediates dignity to the marginalised by healings and public fellowship, elaborates God's new code of honour which reinterprets social stigmas, and procures an exalted status for all peoples by atoning for shame and resurrecting to exaltation. Romans and 1 Peter are interpreted in their socio-historic contexts as apostolic instruments which expound the social implications of God's honour code. To unify the fractured Romans for the upcoming Spanish mission, Paul confronts social imperialism by replacing false honour claims with God's status now available by faith through grace in Christ. Meanwhile, 1 Peter assures maligned Christians of their exalted status and outlines honourable social relations. Then, in closing, we examine a soteriology of honour diachronically and systematically. In particular, how: biblical metaphors symbolise believers’ status transposition, group incorporation is key to New Testament soteriology, Eastern Orthodoxy's doctrine oftheosisarticulates the infusion of divine status, and other theological categories could be interpreted through honour-shame social values. These reflections towards an exegetical soteriology of divine honour are offered as an initial theological platform for addressing social issues where honour values prevail.
Efficient large-scale configuration via integer linear programming
Authors: Feinerer Ingo 
Published: January 2013

AbstractConfiguration of large-scale applications in an engineering context requires a modeling environment that allows the design engineer to draft the configuration problem in a natural way and efficient methods that can process the modeled setting and scale with the number of components. Existing configuration methods in artificial intelligence typically perform quite well in certain subareas but are hard to use for general-purpose modeling without mathematical or logics background (the so-called knowledge acquisition bottleneck) and/or have scalability issues. As a remedy to this important issue both in theory and in practical applications, we use a standard modeling environment like the Unified Modeling Language that has been proposed by the configuration community as a suitable object-oriented formalism for configuration problems. We provide a translation of key concepts of class diagrams to inequalities and identify relevant configuration aspects and show how they are treated as an integer linear program. Solving an integer linear program can be done efficiently, and integer linear programming scales well to large configurations consisting of several thousands components and interactions. We conduct an empirical study in the context of package management for operating systems and for the Linux kernel configuration. We evaluate our methodology by a benchmark and obtain convincing results in support for using integer linear programming for configuration applications of realistic size and complexity.
Improving the link between computer-assisted design and configuration tools for the design of mechanical products
Authors: Raffaeli Roberto , Mengoni Maura , Germani Michele 
Published: January 2013

AbstractThe competitive market forces companies to offer tailored products to meet specific customer needs. To avoid wasting time, design efforts generally address the configuration of existing solutions, without producing substantial design modifications. Configuration tools are used to achieve customized products starting from a common platform. Many approaches have been successfully proposed in literature to configure products. However, in the mechanical field they need further investigation in order to be efficiently linked to computer-aided design technologies. Research is focused on tools and methods to automatically produce geometrical models and improve the flexibility of the continuous product updating process. In this context, this paper aims to combine product configuration approaches with design automation techniques in order to support design activities of products to fulfill specific requirements. The approach is based on entities called configurable virtual prototypes. Three different domains are managed and connected via configurable virtual prototypes: product specifications, geometrical data, and product knowledge. In particular, geometry recognition rules are used to identify the parameterization of parts and the assembly mating constraints. The approach is exemplified through an industrial case study where a tool has been developed on the basis of the described method. Advantages of the system are shown in terms of achieved product configuration efficiency.
Effects of age, sex and activity level on counter‐movement jump performance in children and adolescents
Authors: Focke Anne , Strutzenberger Gerda , Jekauc Darko , Worth Annette , Woll Alexander , Schwameder Hermann 
Published: January 2013

AbstractThe aim of this study was to investigate counter‐movement jump performance and its reliability in children and adolescents with respect to age, sex and activity level. We tested 1835 children and adolescents aged between 4 and 17 years. All participants performed three counter‐movement jumps on a force platform with arms akimbo. The participants were divided into six age groups and subdivided by sex within each group, to analyse age and sex effects. Subsequently, jumping performance of active and sedentary participants was compared. Jump height was calculated and the highest jump out of three was used for the calculations of peak force and peak rate of force development. Variability of all parameters was quantified using the coefficient of variation over all jumps. Jump height increased significantly with increasing age while peak rate of force development decreased. Peak force was similar for all age groups. Jump height was significantly higher in male participants and peak force and peak rate of force development was significantly lower in male participants. Variability of jump height and peak force decreased significantly with increasing age leading to reliable data above the age of 10 years. Peak rate of force development showed a high variability and, therefore, should be interpreted with caution. This could be useful information for coaches as they need to know from which age onwards the counter‐movement jump is applicable in performance diagnostics and which parameters are sensible for interpretation. Finally, the present study provides data to be used as normative references.
Findings of the International Nosocomial Infection Control Consortium (INICC), Part III Effectiveness of a Multidimensional Infection Control Approach to Reduce Central Line—Associated Bloodstream Infections in the Neonatal Intensive Care Units of 4 Developing Countries
Authors: Rosenthal Victor Daniel , Dueñas Lourdes , Sobreyra-Oropeza Martha , Ammar Khaldi , Navoa-Ng Josephine Anne , Casares Ana Conceptión Bran de , Machuca Lilian de Jesús , Ben-Jaballah Nejla , Hamdi Asma , Villanueva Victoria D. , Tolentino María Corazon V. 
Published: January 2013

Objective.To analyze the impact of the International Nosocomial Infection Control Consortium (INICC) multidimensional infection control approach to reduce central line-associated bloodstream infection (CLABSI) rates.Setting.Four neonatal intensive care units (NICUs) of INICC member hospitals from El Salvador, Mexico, Philippines, and Tunisia.Patients.A total of 2,241 patients hospitalized in 4 NICUs for 40,045 bed-days.Methods.We conducted a before-after prospective surveillance study. During Phase 1 we performed active surveillance, and during phase 2 the INICC multidimensional infection control approach was implemented, including the following practices: (1) central line care bundle, (2) education, (3) outcome surveillance, (4) process surveillance, (5) feedback of CLABSI rates, and (6) performance feedback of infection control practices. We compared CLABSI rates obtained during the 2 phases. We calculated crude stratified rates, and, using random-effects Poisson regression to allow for clustering by ICU, we calculated the incidence rate ratio (IRR) for each follow-up time period compared with the 3-month baseline.Results.During phase 1 we recorded 2,105 CL-days, and during phase 2 we recorded 17,117 CL-days. After implementation of the multidimensional approach, the CLABSI rate decreased by 55%, from 21.4 per 1,000 CL-days during phase 1 to 9.7 per 1,000 CL-days during phase 2 (rate ratio, 0.45 [95% confidence interval, 0.33–0.63]). The IRR was 0.53 during the 4–12-month period and 0.07 during the final period of the study (more than 45 months).Conclusions.Implementation of a multidimensional infection control approach was associated with a significant reduction in CLABSI rates in NICUs.
Serum 25‐hydroxyvitamin D and left ventricular systolic function in a non‐smoking population: the Tromsø Study
Authors: Kamycheva Elena , Wilsgaard Tom , Schirmer Henrik , Jorde Rolf 
Published: January 2013

AimsThe myocardium is considered to be an important target organ for parathyroid hormone and 1,25‐dihydroxyvitamin D, the active metabolite of vitamin D. Vitamin D inadequacy has also been linked to cardiovascular morbidity. We aimed to evaluate the relationship between serum 25‐hydroxyvitamin D [25(OH)D] and LV systolic function in a general population.Methods and resultsIn the fourth Tromsø Study, M‐mode echocardiography was performed in 2504 subjects with available serum 25(OH)D measurements. Measurements of EF and LV mass indexed by height (LVMH) were obtained. Only non‐smoking men (n = 790) and women (n = 944) were included in the final analysis. Linear regression was used to assess the association between serum 25(OH)D and measurements of systolic function, and logistic regression was applied to assess the effect of serum 25(OH)D on the lowest quartile of EF (yes/no) and LV hypertrophy (LVH) (yes/no). We found no significant associations between vitamin D concentrations and measures of LV systolic function, when adjusted for other risk factors and the season when 25(OH)D sampling was performed [β –0.03, 95% confidence interval (CI) –0.08 to 0.03, and β –0.01, 95% CI –0.07 to 0.06 for LVMH and EF in men; and β 0.02, 95% CI –0.03 to 0.07, and β 0.01, 95% CI –0.05 to 0.07 for LVMH and EF in women]. Serum 25(OH)D did not predict EF and/or LVH in both genders.ConclusionsIn our population‐based study, increased serum 25(OH)D was not associated with better LV systolic function, when adjusted for other risk factors and for season of vitamin D sampling.
First Report of Lettuce mosaic virus Infecting Lactuca sativa in India
Authors: Sharma P. , Jain R. K. , Saha S. , Kalia P. 
Published: January 2013

In January 2012, lettuce (Lactuca sativa L.) plants (19 out of 38) of one of the accessions (EC687345, variety NVRS-10:001818) exhibiting mild mosaic and stunted growth symptoms were observed at the Indian Agricultural Research Institute (IARI) experimental farm, New Delhi. Similar disease symptoms in lettuce plants in India were previously described (3) and the associated virus was characterized for host range, dilution end point, thermal inactivation point, and longevity in vitro. In this study, definitive molecular evidence is presented for the presence of Lettuce mosaic virus (LMV) infecting lettuce in India. Analysis of preparations from leaves of symptomatic samples with an electron microscope revealed flexuous virus particles measuring 750 × 13 nm, suggesting the association of a potyvirus (4). To identify the potyvirus infecting these lettuce plants, the 3′ terminal portion of the genome including the part of the nuclear inclusion b (NIb), complete coat protein (CP) region, and 3′ untranslated region (UTR) was amplified by RT-PCR, cloned, and sequenced. Total RNA was extracted from infected leaves using an RNeasy Plant Mini Kit (Qiagen, Valencia, CA) and subjected to RT-PCR using potyvirus specific forward (5′ ACCACAGGATCCGGBAAYAAYAGYGGDCARCC 3′) and reverse (5′ CACGGATCCCGGG(T17)V 3′) primers (2). PCR products (~1.8 kb) were cloned into pGEM-T Easy vector (Promega, Madison, WI) and sequenced (GenBank Accession No. JQ794776). Sequence comparisons revealed the CP of the virus infecting lettuce (834 bp) shared 96 to 100% nucleotide and deduced amino acid sequence identity with the corresponding regions of LMV isolates AJ306288 and AJ297630 from the United Kingdom, CAA46603 and NC003605 from the United States, AJ278854 and AJ278854 from Brazil, and AJ488153 from China, thus complying with the cut off range of 90 to 99% for identifying isolates/strains of the same virus (1). Similarly, 99 to 100% nucleotide sequence identity was observed with the corresponding region of the 3′UTR (245 bp) while 93 to 96% nucleotide identity of NIb region (654 bp) with LMV isolates. These results confirm that the virus infecting the symptomatic lettuce plants was an isolate of LMV. The amino acid sequences (DAG and WCIEN) conserved among majority of potyviruses were also present. Since the virus is aphid transmissible, its natural infection on other hosts and spread can't be ruled out. References: (1) M. J. Adams et al. Arch Virol. 150:459, 2005. (2) A. Gibbs and A. Mackenzie. J. Virol. Methods 63:9, 1997. (3) T. K. Nariani and P. S. Pathanian. Indian Phytopathol. 13:172, 1960. (4) D. D. Shukla et al. The Potyviridae, page 338, 1994.
Effect of Proton Pump Inhibitor on Esophageal Eosinophilia
Authors: Schroeder Shauna , Capocelli Kelley E. , Masterson Joanne C. , Harris Rachel , Protheroe Cheryl , Lee James J. , Furuta Glenn T. 
Published: January 2013

ABSTRACTObjective:Differentiation between the common etiologies of dense esophageal eosinophilia such as gastroesophageal reflux disease (GERD) and eosinophilic esophagitis can be difficult. We hypothesized that histologic features may provide diagnostic clues concerning the etiology of esophageal eosinophilia.Methods:We performed a retrospective chart review of 204 children with the diagnosis of esophagitis characterized by ≥15 eosinophils (eos) per high‐power field (HPF) in at least 1 biopsy. We then restricted our analysis to subjects who had received at least 8 weeks of only proton pump inhibitors (PPIs) followed by endoscopy and who had a clinicopathologic response to this treatment. Symptoms, endoscopic findings, and pathologic descriptions were reviewed and an eosinophil peroxidase (EPX) index was determined to assess for degranulation/eosinophil activation.Results:Of the 204 identified charts, 7 subjects identified met the inclusion criteria. Five of these 7 patients showed a clinicopathologic response to PPIs after their follow‐up endoscopy, (mean peak eosinophil count: 92 vs 5 eos/HPF, and EPX index: 39.2 vs 14.6, pre‐ and posttreatment, respectively). Two patients experienced initial resolution of symptoms and esophageal eosinophilia with PPI therapy; however, within 17–23 months they redeveloped symptoms and esophageal eosinophilia while receiving PPI therapy at the time of a third endoscopy (mean peak eosinophil count: 40 vs 11 vs 36 eos/HPF, and EPX index: 44 vs 21 vs 36.5, pre‐, post‐ and posttreatment, respectively). No clinicopathologic features or degranulation patterns differentiated subjects with GERD/PPI responsive esophageal eosinophilia from those who had transient response to PPI treatment.Conclusions:No clinicopathologic features differentiated subjects who responded to PPI treatment. PPI treatment can be helpful to exclude GERD and PPI responsive esophageal eosinophilia but long‐term follow‐up is critical in the management of esophagitis.