bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic influences on resting‐state functional networks: A twin study
Authors: Fu Yixiao , Ma Zhiwei , Hamilton Christina , Liang Zhifeng , Hou Xiao , Ma Xingshun , Hu Xiaomei , He Qian , Deng Wei , Wang Yingcheng , Zhao Liansheng , Meng Huaqing , Li Tao , Zhang Nanyin 
Published: July 2015

AbstractAlterations in resting‐state networks (RSNs) are often associated with psychiatric and neurologic disorders. Given this critical linkage, it has been hypothesized that RSNs can potentially be used as endophenotypes for brain diseases. To validate this notion, a critical step is to show that RSNs exhibit heritability. However, the investigation of the genetic basis of RSNs has only been attempted in the default‐mode network at the region‐of‐interest level, while the genetic control on other RSNs has not been determined yet. Here, we examined the genetic and environmental influences on eight well‐characterized RSNs using a twin design. Resting‐state functional magnetic resonance imaging data in 56 pairs of twins were collected. The genetic and environmental effects on each RSN were estimated by fitting the functional connectivity covariance of each voxel in the RSN to the classic ACE twin model. The data showed that although environmental effects accounted for the majority of variance in wide‐spread areas, there were specific brain sites that showed significant genetic control for individual RSNs. These results suggest that part of the human brain functional connectome is shaped by genomic constraints. Importantly, this information can be useful for bridging genetic analysis and network‐level assessment of brain disorders. Hum Brain Mapp 36:3959–3972, 2015. © 2015 Wiley Periodicals, Inc.
Modeling and control strategies for anoxic biotrickling filtration in biogas purification
Authors: Almenglo Fernando , Ramírez Martín , Gómez José Manuel , Cantero Domingo , Gamisans Xavier , Dorado Antonio David 
Published: July 2015

AbstractBACKGROUNDAnoxic biotrickling filters have been used to 'sweeten' biogas. Nevertheless, the cost and availability of large amounts of nitrate could limit the use of this technology in comparison with aerobic biotrickling filters. The development of a dynamic mathematical model would be useful for the design of control strategies with regard to nitrate dosage.RESULTSA dynamic model has been developed to describe the performance of an anoxic biotrickling filter for biogas desulfurization. The model considers the most relevant phenomena involved in biotrickling filter operation: advection, absorption, diffusion and biodegradation. Moreover, a fraction of the liquid phase is stagnant – an assumption that increases the importance of diffusion phenomena for low liquid flow rates. Once the model had been validated, six control strategies were analyzed for different scenarios and purposes: i.e. to minimize nitrate consumption and/or to maximize H2S removal efficiency.CONCLUSIONThe mathematical model developed from the description of the phenomena involved in the process is a powerful tool to evaluate all possible strategies when considering and quantifying the savings and improvements in different operating modes. © 2015 Society of Chemical Industry
Factors Influencing Pastoral and Agropastoral Household Vulnerability to Food Insecurity in the Drylands of Kenya: A Case Study of Kajiado and Makueni Counties
Authors: Amwata Dorothy A. , Nyariki Dickson M. , Musimba Nashon R. K. 
Published: July 2015

AbstractThis study establishes the determinants of household vulnerability to food insecurity in pastoral households of Kajiado and agropastoral households of Makueni Counties of Kenya. A randomly selected sample of 198 households was interviewed. Descriptive analysis showed that pastoral households of Kajiado County were more vulnerable to food insecurity (VFI) with a VFI of 0.59 than agropastoral households in Makueni County, who had a VFI of 0.27. Further, a two stage least squares approach established that vulnerability of households to food insecurity is determined by land size, household size, rainfall and herd size for Makueni County and access to climate information, herd size, off‐farm employment and gender of the household head for Kajiado County. The findings imply that Makueni County needs access to and control over land resources, destocking through improved livestock breeds and creation of a microclimate to enhance rainfall levels. For Kajiado County, policies need to promote access to climate information, diversification of livelihoods and female access to production resources. Copyright © 2015 John Wiley & Sons, Ltd.
Prevention of post‐traumatic reinnervation with microtubule inhibitors
Authors: Park Andrea M. , Dhanda Patil Reena , Paniello Randal C. 
Published: July 2015

Objectives/HypothesisFunctional recovery after a recurrent laryngeal nerve or facial nerve injury may be impaired due to aberrant reinnervation. Previous work in a rat peripheral nerve injury model found vincristine to be a potent inhibitor of reinnervation, and it has since been used to effectively block neural regeneration in other animal models. However, vincristine's narrow therapeutic index may limit its utility; therefore, another microtubule inhibitor, paclitaxel, which has a higher therapeutic index, was tested.Study DesignAnimal (rat) study.MethodsAfter controlled injury to the rat posterior tibial (PT) nerve, the gastrocnemius/soleus complex was injected with saline (control, n = 14), vincristine (n = 30), or paclitaxel (n = 20). Injections without a crush injury were performed using saline (n = 5) or paclitaxel (n = 9). The functional recovery (FR) of the PT nerve was assessed using walking track analysis.ResultsAt 6 weeks, controls had already recovered to baseline (FR = 1.0), whereas the paclitaxel group had FR = 0.724 ± 0.064 and the vincristine group had FR = 0.709 ± 0.078. At 6 months, the paclitaxel rats had FR = 0.798 ± 0.167 and the vincristine rats had FR = 0.754 ± 0.240. These differences were significantly different from baseline, but the two agents were not different from each other. Paclitaxel did not affect the FR in the absence of a nerve injury.ConclusionsIntramuscular paclitaxel and vincristine both significantly inhibit regeneration of the PT nerve after crush injury for at least 6 months. Potential clinical uses of inhibition of reinnervation are discussed.Level of EvidenceNA Laryngoscope, 125:E333–E337, 2015
Evaluating hypertrophic thyroidectomy scar outcomes after treatment with triamcinolone injections and copper bromide laser therapy
Authors: On Hye Rang , Lee Sang Hee , Lee Yong Sang , Chang Hang‐Seok , Park CheongSoo , Roh Mi Ryung 
Published: July 2015

Background and ObjectivesPostoperative hypertrophic scar following thyroidectomy can be a major concern due to its disfiguring appearance. Recently, copper bromide laser (CBL) and intralesional triamcinolone injection (TA ILI) have been used to treat hypertrophic thyroidectomy scars. Data regarding the number of treatment sessions needed to reach a certain endpoint and the prognostic factors that affect treatment duration are unknown. The aim of this study was to evaluate the number of treatment sessions required to reduce VSS score by 50%, which was regarded as the treatment endpoint, and to investigate the factors that influence treatment duration when using CBL and TA ILI.Materials and MethodsA total of 67 patients were enrolled in this study. Baseline characteristics of the patients including age, sex, body mass index (BMI), distance of the scar from the sternal notch, time of development of the hypertrophic scar, sternocleidomastoid (SCM) muscle prominence, and date of operation were collected on the first visit. They were treated with CBL and TA. The concentration of triamcinolone used was 2.5 mg/ml or 5 mg/ml according to the pliability score of each scar.ResultsThe mean number of treatment sessions required to achieve the endpoint was 3.85 ± 1.25. Among the variables assessed, location of the scar near the sternal notch (P = 0.020) and patient BMI (P = 0.001) were associated with the increasing number of treatment sessions.ConclusionIn our study cohort, four treatments were required to reduce the VSS of thyroidectomy scars by 50% when using a combination treatment of CBL and low concentration TA ILI. Also, scar location and patient BMI are factors that affect treatment outcome. Lasers Surg. Med. 47:479–484, 2015. © 2015 Wiley Periodicals, Inc.
The effect of low‐level laser therapy (LLLT) applied prior to muscle injury
Authors: Ribeiro Beatriz Guimarães , Alves Agnelo Neves , Santos Lucas Andreo Dias dos , Fernandes Kristianne Porta Santos , Cantero Tatiane Matarazzo , Gomes Mariana Teixeira , França Cristiane Miranda , de Fátima Teixeira da Silva Daniela , Bussadori Sandra Kalil , Mesquita‐Ferrari Raquel Agnelli 
Published: July 2015

AimTo evaluate the effect of LLLT (780 nm; 10 J/cm2, 40 mW, 3.2 J) prior to injury on the morphological analysis, collagen deposition, and activity of matrix metalloproteinase‐2 (MMP‐2).MethodsWistar rats were divided into groups: control; sham; only LLLT; only muscle injury and LLLT + injury. The rats were euthanized at 1, 3, and 7 days following cryoinjury to muscle that was removed for analysis.ResultsLLLT applied prior to muscle injury led to a reduction in myonecrosis and inflammatory cells, an increase of blood vessels and immature muscle fibers. An increase in MMP‐2 activity and a decrease in collagen deposition were also found, with a better collagen organization and distribution.ConclusionLLLT applied immediately prior to injury had positive effects during the muscle regeneration process. Therefore, this resource may have considerable therapeutic value, especially for athletes who practice sports in which there is a constant risk of muscle injury. Lasers Surg. Med. 47:571–578, 2015. © 2015 Wiley Periodicals, Inc.
Validity of diagnostic codes and laboratory measurements to identify patients with idiopathic acute liver injury in a hospital database
Authors: Udo Renate , Maitland‐van der Zee Anke H. , Egberts Toine C. G. , den Breeijen Johanna H. , Leufkens Hubert G. M. , van Solinge Wouter W. , De Bruin Marie L. 
Published: July 2015

AbstractPurposeThe development and validation of algorithms to identify cases of idiopathic acute liver injury (ALI) are essential to facilitate epidemiologic studies on drug‐induced liver injury. The aim of this study is to determine the ability of diagnostic codes and laboratory measurements to identify idiopathic ALI cases.MethodsIn this cross‐sectional validation study, patients were selected from the hospital‐based Utrecht Patient Oriented Database between 2008 and 2010. Patients were identified using (I) algorithms based on ICD‐9‐CM codes indicative of idiopathic ALI combined with sets of liver enzyme values (ALT > 2× upper limit of normal (ULN); AST > 1ULN + AP > 1ULN + bilirubin > 1ULN; ALT > 3ULN; ALT > 3ULN + bilirubin > 2ULN; ALT > 10ULN) and (II) algorithms based on solely liver enzyme values (ALT > 3ULN + bilirubin > 2ULN; ALT > 10ULN). Hospital medical records were reviewed to confirm final diagnosis. The positive predictive value (PPV) of each algorithm was calculated.ResultsA total of 707 cases of ALI were identified. After medical review 194 (27%) patients had confirmed idiopathic ALI. The PPV for (I) algorithms with an ICD‐9‐CM code as well as abnormal tests ranged from 32% (13/41) to 48% (43/90) with the highest PPV found with ALT > 2ULN. The PPV for (II) algorithms with liver test abnormalities was maximally 26% (150/571).ConclusionsThe algorithm based on ICD‐9‐CM codes indicative of ALI combined with abnormal liver‐related laboratory tests is the most efficient algorithm for identifying idiopathic ALI cases. However, cases were missed using this algorithm, because not all ALI cases had been assigned the relevant diagnostic codes in daily practice. Copyright © 2015 John Wiley & Sons, Ltd.
Association between drug‐specific indicators of prescribing quality and quality of drug treatment: a validation study
Authors: Wallerstedt Susanna M. , Belfrage Björn , Fastbom Johan 
Published: July 2015

AbstractPurposeTo evaluate the concurrent validity of three European sets of drug‐specific indicators of prescribing qualityMethodsIn 200 hip fracture patients (≥65 years), consecutively recruited to a randomized controlled study in Sahlgrenska University Hospital in 2009, quality of drug treatment at study entry was assessed according to a gold standard as well as to three drug‐specific indicator sets (Swedish National Board of Health and Welfare, French consensus panel list, and German PRISCUS list). As gold standard, two specialist physicians independently assessed and then agreed on the quality for each patient, after initial screening with STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions) and START (Screening Tool to Alert to Right Treatment).ResultsAccording to the Swedish, French, and German indicator sets, 82 (41%), 54 (27%), and 43 (22%) patients had potentially inappropriate drug treatment. A total of 141 (71%) patients had suboptimal drug treatment according to the gold standard. The sensitivity for the indicator sets was 0.51 (95% confidence interval: 0.43; 0.59), 0.33 (0.26; 0.41), and 0.29 (0.22; 0.37), respectively. The specificity was 0.83 (0.72; 0.91), 0.88 (0.77; 0.94), and 0.97 (0.88; 0.99). Suboptimal drug treatment was 2.0 (0.8; 5.3), 1.9 (0.7; 5.1), and 6.1 (1.3; 28.6) times as common in patients with potentially inappropriate drug treatment according to the indicator sets, after adjustments for age, sex, cognition, residence, multi‐dose drug dispensing, and number of drugs.ConclusionsIn this setting, the indicator sets had high specificity and low sensitivity. This needs to be considered upon use and interpretation. Copyright © 2015 The Authors Pharmacoepidemiology and Drug Safety Published by John Wiley & Sons, Ltd.
Proteomic analysis of integrin‐associated complexes from mesenchymal stem cells
Authors: Ajeian Jila N. , Horton Edward R. , Astudillo Pablo , Byron Adam , Askari Janet A. , Millon‐Frémillon Angélique , Knight David , Kimber Susan J. , Humphries Martin J. , Humphries Jonathan D. 
Published: July 2015

PurposeMultipotent mesenchymal stem cells (MSCs) have the capability to differentiate down adipocyte, osteocyte and chondrocyte lineages and as such offer a range of potential therapeutic applications. The composition and stiffness of the extracellular matrix (ECM) environment that surrounds cells dictates their transcriptional programme, thereby affecting stem cell lineage decision‐making. Cells sense force via linkages between themselves and their microenvironment, and this is transmitted by integrin receptors and associated adhesion signalling complexes. To identify regulators of MSC force sensing, we sought to catalogue MSC integrin‐associated adhesion complex composition.Experimental designAdhesion complexes formed by MSCs plated on the ECM ligand fibronectin were isolated and characterised by MS. Identified proteins were interrogated by comparison to a literature‐based reference set of cell adhesion‐related components and using ontological and protein–protein interaction network analyses.ResultsAdhesion complex‐specific proteins in MSCs were identified that comprised predominantly cell adhesion‐related adaptors and actin cytoskeleton regulators. Furthermore, LIM domain‐containing proteins in MSC adhesion complexes were highlighted, which may act as force‐sensing components.Conclusion and clinical relevanceThese data provide a valuable resource of information regarding the molecular connections that link integrins and adhesion signalling in MSCs, and as such may present novel opportunities for therapeutic intervention.
Gas‐phase conformations of capistruin – comparison of lasso, branched‐cyclic and linear topologies
Authors: Jeanne Dit Fouque Kevin , Lavanant Hélène , Zirah Séverine , Lemoine Jérôme , Rebuffat Sylvie , Tabet Jean‐Claude , Kulesza Alexander , Afonso Carlos , Dugourd Philippe , Chirot Fabien 
Published: July 2015

RationaleCapistruin is a peptide synthesized by Burkholderia thailandensis E264, which displays a lasso topology. This knot‐like structure confers interesting properties to peptides (e.g. antibacterial). Therefore, it is important to evaluate the sensitivity of structural characterization methods to such topological constraints.MethodsIon mobility mass spectrometry (IMS‐MS) experiments, using both drift tube and travelling wave instruments, were performed on lasso capistruin and on peptides with the same sequence, but displaying a branched‐cyclic (un‐threaded) or linear topology. Molecular dynamics (MD) simulations were then performed to further interpret the IMS results in terms of conformation.ResultsThe collision cross sections (CCSs) measured via IMS for the different forms of capistruin were found to be similar, despite their different topologies for the doubly charged species, but significant differences arise as the charge state is increased. MD simulations for the doubly charged linear peptide were consistent with the hypothesis that salt bridges are present in the gas phase. Moreover, through CCS measurements for peptides with site‐specific mutations, the arginine residue at position 11 was found to play a major role in the stabilization of compact structures for the linear peptide.ConclusionsDifferences in peptide topologies did not yield marked signatures in their respective IMS spectra. Such signatures were only visible for relatively high charge states, that allow Coulomb repulsion to force unfolding. At low charge states, the topologically unconstrained linear form of capistruin was found to adopt charge solvation‐constrained structures, possibly including salt bridges, with CCSs comparable to those measured for the topologically constrained lasso form. Copyright © 2015 John Wiley & Sons, Ltd.
Thermodynamic study of gaseous tin molybdates by high‐temperature mass spectrometry
Authors: Shugurov Sergey M. , Panin Andrej I. , Lopatin Sergey I. , Emelyanova Ksenia A. 
Published: July 2015

RationaleMolybdenum and tin are components of various construction materials which are often used at high temperature and in an oxidizing atmosphere. Oxides of molybdenum and tin, with their high reactivity, can, in their turn, form a number of gaseous compounds. To predict the possibility of the existence of gaseous associates formed by tin and molybdenum oxides it is important to know their thermodynamic characteristics. Until the present investigation only a few gaseous salts of tin were known.MethodsHigh‐temperature Knudsen effusion mass spectrometry was used to determine the partial pressures of vapor species over the SnO2–MoO3 system. The formation enthalpies of gaseous SnMoO4, Sn2MoO5 and SnMo2O7 were derived. Measurements were performed with a MS‐1301 mass spectrometer. Vaporization was carried out using a molybdenum effusion cell containing the samples under study and pure gold as the reference substance. A theoretical study of gaseous tin molybdates was performed by several quantum chemical methods: wave function based explicitly correlated F12 methods and DFT M06 methods.ResultsIn the temperature range of 1200–1400 K, SnO, Sn2O2, SnMoO4, Sn2MoO5, SnMo2O7, MoO3, Mo2O6 and Mo3O9 were found to be the main vapor species over the samples studied. On the basis of the equilibrium constants of gaseous reactions, the standard formation enthalpies of gaseous SnMoO4 (–699 ± 29 kJ/mol), Sn2MoO5 (–1001 ± 38 kJ/mol) and SnMo2O7 (–1456 ± 60 kJ/mol) at 298 K were determined. Energetically favorable structures were found and vibrational frequencies were evaluated in the harmonic approximation.ConclusionsThe stability of gaseous species, SnMoO4, Sn2MoO5 and SnMo2O7, was confirmed by high‐temperature mass spectrometry. A number of gas‐phase reactions involving tin‐containing gaseous salts were studied. The enthalpies of reactions of gaseous tin molybdates were evaluated theoretically and the obtained values are in agreement with those obtained experimentally. Copyright © 2015 John Wiley & Sons, Ltd.
Rainbow matchings and Hamilton cycles in random graphs
Authors: Bal Deepak , Frieze Alan 
Published: July 2015

AbstractLet be drawn uniformly from all m‐edge, k‐uniform, k‐partite hypergraphs where each part of the partition is a disjoint copy of . We let be an edge colored version, where we color each edge randomly from one of colors. We show that if and where K is sufficiently large then w.h.p. there is a rainbow colored perfect matching. I.e. a perfect matching in which every edge has a different color. We also show that if n is even and where K is sufficiently large then w.h.p. there is a rainbow colored Hamilton cycle in . Here denotes a random edge coloring of with n colors. When n is odd, our proof requires for there to be a rainbow Hamilton cycle. © 2015 Wiley Periodicals, Inc. Random Struct. Alg., 48, 503–523, 2016
Long-Term RST Analysis of Anomalous TIR Sequences in Relation with Earthquakes Occurred in Greece in the Period 2004–2013
Authors: Eleftheriou Alexander , Filizzola Carolina , Genzano Nicola , Lacava Teodosio , Lisi Mariano , Paciello Rossana , Pergola Nicola , Vallianatos Filippos , Tramutoli Valerio 
Published: July 2015

AbstractReal-time integration of multi-parametric observations is expected to accelerate the process toward improved, and operationally more effective, systems for time-Dependent Assessment of Seismic Hazard (t-DASH) and earthquake short-term (from days to weeks) forecast. However, a very preliminary step in this direction is the identification of those parameters (chemical, physical, biological, etc.) whose anomalous variations can be, to some extent, associated with the complex process of preparation for major earthquakes. In this paper one of these parameters (the Earth’s emitted radiation in the Thermal InfraRed spectral region) is considered for its possible correlation withM ≥ 4 earthquakes occurred in Greece in between 2004 and 2013. The Robust Satellite Technique (RST) data analysis approach and Robust Estimator of TIR Anomalies (RETIRA) index were used to preliminarily define, and then to identify, significant sequences of TIR anomalies (SSTAs) in 10 years (2004–2013) of daily TIR images acquired by the Spinning Enhanced Visible and Infrared Imager on board the Meteosat Second Generation satellite. Taking into account the physical models proposed for justifying the existence of a correlation among TIR anomalies and earthquake occurrences, specific validation rules (in line with the ones used by the Collaboratory for the Study of Earthquake Predictability—CSEP—Project) have been defined to drive a retrospective correlation analysis process. The analysis shows that more than 93 % of all identified SSTAs occur in the prefixed space–time window around (M ≥ 4) earthquake's time and location of occurrence with a false positive rate smaller than 7 %. Molchan error diagram analysis shows that such a correlation is far to be achievable by chance notwithstanding the huge amount of missed events due to frequent space/time data gaps produced by the presence of clouds over the scene. Achieved results, and particularly the very low rate of false positives registered on a so long testing period, seems already sufficient (at least) to qualify TIR anomalies (identified by RST approach and RETIRA index) among the parameters to be considered in the framework of a multi-parametric approach to t-DASH.