bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multiple Multicomponent Approach to Chimeric Peptide–Peptoid Podands
Authors: Rivera Daniel G. , León Fredy , Concepción Odette , Morales Fidel E. , Wessjohann Ludger A. 
Published: March 2013

AbstractThe success of multi‐armed, peptide‐based receptors in supramolecular chemistry traditionally is not only based on the sequence but equally on an appropriate positioning of various peptidic chains to create a multivalent array of binding elements. As a faster, more versatile and alternative access toward (pseudo)peptidic receptors, a new approach based on multiple Ugi four‐component reactions (Ugi‐4CR) is proposed as a means of simultaneously incorporating several binding and catalytic elements into organizing scaffolds. By employing α‐amino acids either as the amino or acid components of the Ugi‐4CRs, this multiple multicomponent process allows for the one‐pot assembly of podands bearing chimeric peptide–peptoid chains as appended arms. Tripodal, bowl‐shaped, and concave polyfunctional skeletons are employed as topologically varied platforms for positioning the multiple peptidic chains formed by Ugi‐4CRs. In a similar approach, steroidal building blocks with several axially‐oriented isocyano groups are synthesized and utilized to align the chimeric chains with conformational constrains, thus providing an alternative to the classical peptido‐steroidal receptors. The branched and hybrid peptide–peptoid appendages allow new possibilities for both rational design and combinatorial production of synthetic receptors. The concept is also expandable to other multicomponent reactions.
Wide‐Ranging Host Capability of a PdII‐Linked M2L4 Molecular Capsule with an Anthracene Shell
Authors: Kishi Norifumi , Li Zhiou , Sei Yoshihisa , Akita Munetaka , Yoza Kenji , Siegel Jay S. , Yoshizawa Michito 
Published: March 2013

AbstractThis article reports that an M2L4 molecular capsule is capable of encapsulating various neutral molecules in quantitative yields. The capsule was obtained as a single product by mixing a small number of components; two PdII ions and four bent bispyridine ligands containing two anthracene panels. Detailed studies of the host capability of the PdII‐linked capsule revealed that spherical (e.g., paracyclophane, adamantanes, and fullerene C60), planar (e.g., pyrenes and triphenylene), and bowl‐shaped molecules (e.g., corannulene) were encapsulated in the large spherical cavity, giving rise to 1:1 and 1:2 host–guest complexes, respectively. The volume of the encapsulated guest molecules ranged from 190 to 490 Å3. Within the capsule, the planar guests adopt a stacked‐dimer structure and the bowl‐shaped guests formed an unprecedented concave‐to‐concave capsular structure, which are fully shielded by the anthracene shell. Competitive binding experiments of the capsule with a set of the planar guests established a preferential binding series for pyrenes≈phenanthrene>triphenylene. Furthermore, the capsule showed the selective formation of an unusual ternary complex in the case of triphenylene and corannulene.
ChemInform Abstract: Self‐Compensation Property of β‐Rhombohedral Boron Doped with High Li Concentration.
Authors: Hyodo H. , Nezu A. , Soga K. , Kimura K. 
Published: March 2013

AbstractA high concentration of Li (up to LiB5.8) is doped into β‐rhombohedral boron (sealed stainless‐steel tube, Ar, 1000 °C, 24 h).
ChemInform Abstract: Dehydration of Magnesium Bromide Hexahydrate Studied by in situ X‐Ray Powder Diffraction.
Authors: Dinnebier Robert E. , Runcevski Tomce , Sugimoto Kunihisa 
Published: March 2013

AbstractThe dehydration process of MgBr2·6H2O is characterized by powder XRD in the temperature range of 300—420 K.
ChemInform Abstract: Microwave‐Assisted Synthesis of Eu3+ Doped Lanthanum Orthoborates, Their Characterizations and Luminescent Properties.
Authors: Badan Cansin , Esenturk Okan , Yilmaz Aysen 
Published: March 2013

AbstractLaBO3 with various particle sizes and 2.5, 5.0, and 7.5% Eu doped LaBO3 are prepared by microwave‐assisted combustion and sol—gel synthesis methods.
ChemInform Abstract: Assembly of a Gigantic Polyoxometalate Cluster {W200Co8O660} in a Networked Reactor System.
Authors: Ruiz de la Oliva Andreu , Sans Victor , Miras Haralampos N. , Yan Jun , Zang Hongying , Richmond Craig J. , Long De‐Liang , Cronin Leroy 
Published: March 2013

Abstract{(Me2NH2)6 [H4CoW11O39] ·6H2O}n (I), Na4(Me2NH2)10 [H4CoW22O76(H2O)2] ·20H2O (II), and Na16(Me2NH2)72 [H16Co8W200O660 (H2O)40]·ca.600H2O (III) are synthesized in a networked reactor system (three primary reactors, each with two external reagent inputs, are connected together in a triangular arrangement with a central secondary reactor) from aqueous solutions of Na2WO4, CoCl2, Me2NH·HCl, Na2S2O4, and HCl.
ChemInform Abstract: Synthesis and Characterization of Alkyl‐Imidazolium‐Based Periodic Mesoporous Organosilicas: A Versatile Host for the Immobilization of Perruthenate (RuO4‐) in the Aerobic Oxidation of Alcohols.
Authors: Karimi Babak , Elhamifar Dawood , Yari Omolbanin , Khorasani Mojtaba , Vali Hojatollah , Clark James H. , Hunt Andrew J. 
Published: March 2013

AbstractThe catalyst can be recycled and used in at least four runs with only a slight loss in activity.
ChemInform Abstract: Nitrate as a Redox Co‐Catalyst for the Aerobic Pd‐Catalyzed Oxidation of Unactivated sp3‐C—H Bonds.
Authors: Stowers Kara J. , Kubota Asako , Sanford Melanie S. 
Published: March 2013

AbstractThe present new method is applicable to both oxime ether and pyridine derivatives.
ChemInform Abstract: Highly Efficient Double‐Carbonylation of Amines to Oxamides Using Gold Nanoparticle Catalysts.
Authors: Mitsudome Takato , Noujima Akifumi , Mizugaki Tomoo , Jitsukawa Koichiro , Kaneda Kiyotomi 
Published: March 2013

AbstractThe catalyst is recoverable and reusable without any loss of its activity or selectivity.
ChemInform Abstract: Simple and Practical Method for Preparation of [(Diacetoxy)iodo]arenes with Iodoarenes and m‐Chloroperoxybenzoic Acid.
Authors: Iinuma Masataka , Moriyama Katsuhiko , Togo Hideo 
Published: March 2013

AbstractIodoarenes (I) are subjected to reaction with MCPBA in acetic acid and the products (III) can be obtained by precipitation and subsequent filtration.
ChemInform Abstract: Enantioselective Addition of Diethylzinc to Aldehydes by Chiral Oxazolidine—Titanium Complex.
Authors: Wu Nan , Bo Rongcheng , Zhang Rongli , Jiang Xi , Wan Yu , Xu Zhou , Wu Hui 
Published: March 2013

AbstractSubstrates bearing electron‐withdrawing substituents afford the products with higher enantioselectivities.
ChemInform Abstract: Synthesis of α‐Aryl Enaminones Through Reactions of β‐Aryl Enones with Benzyl Azide.
Authors: Cunha Silvio , Gomes Amenson Trindade 
Published: March 2013

AbstractThe BF3·OEt2‐promoted reaction of benzalacetones and dibenzalacetones with azide (II) is investigated.
ChemInform Abstract: Palladium‐Catalyzed Cyclization of Cyclopropyl‐Substituted 1,6‐Enynes to 5.7‐Bicyclic Trienes or Monocyclic Trienes Depending upon the Leaving Group.
Authors: Oh Hye Mi , Sim So Hee , Lee Sang Ick , Kim Jisu , Chung Young Keun 
Published: March 2013

AbstractThe cyclization of cyclopropyl‐substituted enynes proceeds in two ways depending on the presence or absence of a leaving group.
ChemInform Abstract: Synthesis of Novel Heterocyclic Systems, Benzo[b]furobenzimidazoles.
Authors: Maisuradze M. G. , Ananiashvili V. O. , Gaxokidze N. Z. , Matnadze M. M. , Tsqvitaia S. P. 
Published: March 2013

AbstractTwo new tetracyclic heterocompounds are obtained by cyclization under modified Phillips conditions within short reaction times.
ChemInform Abstract: Synthesis of Novel Imidazolium and Benzimidazolium Salts from Halomethyl Derivatives of 4‐Pyrones.
Authors: Ghasemi Zarrin , Gholamhoseini‐Nazari Mahdi , Allahvirdinesbat Maryam , Saraei Mahnaz , Shahrisa Aziz 
Published: March 2013

AbstractA wide range of precursors of functionalized N‐heterocyclic carbenes and potentially ionic liquids is prepared.
ChemInform Abstract: Synthesis of Dihydropyrano[c]chromenes from Hydroxycoumarins Using Aliquat®336 Catalyzed Condensation in Aqueous Medium.
Authors: Patra Amarendra , Mahapatra Tanusri 
Published: March 2013

AbstractHydroxycoumarin, malononitrile and aromatic aldehydes react under microwave irradiation to afford the title compounds in high yields.
ChemInform Abstract: Carbonic Anhydrase Inhibitors. Regioselective Synthesis of Novel Series 1‐Substituted 1,4‐Dihydro‐4‐oxo‐3‐pyridinesulfonamides and Their Inhibition of the Human Cytosolic Isozymes I and II and Transmembrane Cancer‐Associated Isozymes IX and XII.
Authors: Brzozowski Zdzislaw , Slawinski Jaroslaw , Vullo Daniela , Supuran Claudiu T. 
Published: March 2013

AbstractA series of novel sulfonamides (III) (24 examples) are synthesized and investigated as inhibitors of four isoforms of zinc enzyme carbonic anhydrase.
ChemInform Abstract: Synthesis of 1‐Substituted 5‐Acetyl (Ethoxycarbonyl)‐2,3‐dihydropyrazolo[3,4‐b]pyridin‐3‐ones
Authors: Lebed P. S. , Mozgovaya N. G. , Manoilenko O. V. , Tolmachova V. S. , Vovk M. V. 
Published: March 2013

Abstractvia thermal intramolecular cyclization of dihydropyrazolylaminomethylidene β‐dicarbonyl derivatives (III)
ChemInform Abstract: Anellation of 8‐(2‐Propynylsulfanyl)quinoline.
Authors: Potapov V. A. , Malinovich D. A. , Amosova S. V. , Bhasin K. K. 
Published: March 2013

AbstractNew compound methylthieno[3,2‐h]quinoline (II) synthesized by cyclization of (propynylsulfanyl)quinoline in pyridine.
ChemInform Abstract: One‐Pot Synthesis of 3‐Aryl‐Substituted 1‐Hydroxy‐2‐acylindolizines.
Authors: Kloubert Tobias , Kretschmer Robert , Goerls Helmar , Krieck Sven , Westerhausen Matthias 
Published: March 2013

AbstractTitle compounds prepared by reaction of 1,3‐dicarbonyl compounds (I) with aldehydes are obtained as single crystals and their X‐ray structures are given and discussed.
ChemInform Abstract: Preparation of Isoindolo[2,1‐a]quinoxalines Based on N‐(2‐Aminophenyl)isoindole Derivatives.
Authors: Sypchenko V. V. , Potikha L. M. , Kovtunenko V. A. , Baumer V. N. , Shishkin O. V. 
Published: March 2013

AbstractCompound (III) is used as starting material for a series leading to several derivatives of isoindolo[2,1‐a]quinoxaline.
ChemInform Abstract: Docking Studies, Synthesis, Characterization of Some Novel Oxazine Substituted 9‐Anilinoacridine Derivatives and Evaluation for Their Antioxidant and Anticancer Activities as Topoisomerase II Inhibitors.
Authors: Kalirajan R. , Kulshrestha Vivek , Sankar S. , Jubie S. 
Published: March 2013

AbstractNovel acridine derivatives (IIIa) and (IIIc)—(IIIe) have significant anticancer activity against Daltons Lymphoma Ascites (DLA) cells.
ChemInform Abstract: Synthesis of Polycyclic Imidazo[1,4]thiazine Derivatives by an ANRORC Domino Reaction.
Authors: Voskressenky Leonid G. , Festa Alexey A. , Sokolova Ekaterina A. , Khrustalev Victor N. , Varlamov Alexey V. 
Published: March 2013

AbstractFor the first time a multistep anionic domino reaction incorporating an ANRORC (addition of nucleophile/ ring opening/ ring closure) transformation is presented.
Double diffusive convection and thermodiffusion of fullerene–toluene nanofluid in a porous cavity
Authors: Ahadi Amirhossein , Yousefi Tooraj , Saghir M. Ziad 
Published: March 2013

AbstractThe full Brinkman equation coupled with the heat and mass transfer equations was solved numerically using the finite element technique. A square cavity filled with hydrocarbon nanofluid of fullerene–toluene with different concentration values of fullerene was subject to various heating conditions. Results have confirmed that in the presence of nanofluid a heat transfer enhancement is present until a certain amount of initial concentration of the nanofluids. The heat convection coefficient was found to be 16% higher when nanofluid is used as the wetting fluid. In addition, it was determined that the concentration of fullerene in toluene has its limitation in heat removal enhancement. In fact, beyond 5% of fullerene, there is no noticeable enhancement of the heat removal in the system. The model was also used to study thermodiffusion effects in the cavity. Despite the small value and negligible effects of thermodiffusion in general heat and mass transfer problems, which is <5% in the case of studying nanofluids, a maximum value of 20% variation of fullerene concentration has been detected. Moreover, fullerene separation was investigated for different heating intensities. As the Rayleigh number increases, the mixing was found to reduce the separation, which diminishes the Soret effect in the system.
A developed smart technique to predict minimum miscible pressure—eor implications
Authors: Zendehboudi Sohrab , Ahmadi Mohammad Ali , Bahadori Alireza , Shafiei Ali , Babadagli Tayfun 
Published: March 2013

AbstractMiscible gas injection (MGI) processes such as miscible CO2flooding have been in use as attractive EOR options, especially in conventional oil reserves. Optimal design of MGI is strongly dependent on parameters such as gas–oil minimum miscibility pressure (MMP), which is normally determined through expensive and time‐consuming laboratory tests. Thus, developing a fast and reliable technique to predict gas–oil MMP is inevitable. To address this issue, a smart model is developed in this paper to forecast gas–oil MMP on the basis of a feed‐forward artificial neural network (FF‐ANN) combined with particle swarm optimisation (PSO). The MMP of a reservoir fluid was considered as a function of reservoir temperature and the compositions of oil and injected gas in the proposed model. Results of this study indicate that reservoir temperature among the input parameters selected for the PSO–ANN has the greatest impact on MMP value. The developed PSO–ANN model was examined using experimental data, and a reasonable match was attained showing a good potential for the proposed predictive tools in estimation of gas–oil MMP. Compared with other available methods, the proposed model is capable of forecasting oil–gas MMP more accurately in wide ranges of thermodynamic and process conditions. All predictive models used other than the PSO–ANN model failed in providing a good estimate of the oil–gas MMP of the hydrocarbon mixtures in Azadegan oilfield, Iran. © 2013 Canadian Society for Chemical Engineering
The importance of k‐space trajectory on off‐resonance artifact in segmented echo‐planar imaging
Authors: Bender Jacob A. , Ahmad Rizwan , Simonetti Orlando P. 
Published: March 2013

AbstractSegmented interleaved echo planar imaging (EPI) is a highly efficient data acquisition technique; however, EPI is sensitive to artifacts from off‐resonance spins. The choice of k‐space trajectories is important in determining how off‐resonance spins contribute to image artifacts. Top‐down and center‐out trajectories are theoretically analyzed, simulated, implemented, and tested in phantom and volunteer experiments. Theoretical results show off‐resonance artifact manifests as a simple positional shift for the top‐down trajectory, while for the center‐out trajectory off‐resonance artifact manifests as a splitting of the object, which entails both shift and blurring. These results were validated using simulation and phantom scan data where a frequency‐offset was introduced ranging from −300 Hz to +300 Hz. As predicted by the theoretical results, inferior image quality was observed for the center‐out trajectory in a single volunteer. Off‐resonance produces more severe and complex artifacts with the center‐out trajectory than the top‐down trajectory. © 2013 Wiley Periodicals, Inc. Concepts Magn Reson Part 42A: 23–31, 2013.
Sodium‐glucose cotransporter 2‐mediated oxidative stress augments advanced glycation end products‐induced tubular cell apoptosis
Authors: Maeda Sayaka , Matsui Takanori , Takeuchi Masayoshi , Yamagishi Sho‐ichi 
Published: March 2013

AbstractBackgroundNinety percent of glucose filtered by the glomerulus is reabsorbed by a sodium‐glucose cotransporter 2 (SGLT2), which is expressed mainly on the apical membrane of renal proximal tubules. Because blockade of SGLT2 promotes urinary glucose excretion and thereby improves hyperglycaemia, selective inhibition of SGLT2 has been proposed as a potential therapeutic target for the treatment of patients with diabetes. Moreover, advanced glycation end products (AGEs)‐receptor (RAGE) system induces apoptosis of tubular cells, thereby playing a role in diabetic nephropathy as well. However, the pathophysiological crosstalk of SGLT2 with AGEs–RAGE axis and its role in diabetic nephropathy remains unknown.MethodsThis study investigated whether and how blockade of SGLT2 could prevent AGEs‐elicited apoptosis of high glucose‐exposed proximal tubular cells in vitro.ResultsSGLT2 was expressed in tubular cells. Tubular SGLT2 expression and glucose entry into the cells were completely blocked by the treatment with small interfering RNAs (siRNAs) raised against SGLT2. High glucose increased reactive oxygen species generation and RAGE expression levels in tubular cells, both of which were partly suppressed by SGLT2 siRNAs or an antioxidant, N‐acetylcysteine. Further, high glucose was found to augment the AGEs‐induced tubular cell apoptosis, which was also inhibited by SGLT2 siRNAs.ConclusionsOur present data suggest that SGLT2‐mediated, high glucose‐induced reactive oxygen species generation could augment the AGEs‐induced apoptotic cell death of tubular cells via RAGE induction. SGLT2 may play some role in tubular apoptosis in diabetic nephropathy. Copyright © 2013 John Wiley & Sons, Ltd.
Crystallographic Space Group Choice and Its Chemical Consequences: Revised Crystal Structure of [Fe(phen)2Cl2]NO3
Authors: Huang Yuxing , Moret Marc‐Etienne , Klein Gebbink Robertus J. M. , Lutz Martin 
Published: March 2013

AbstractThe crystal structure of [Fe(phen)2Cl2]NO3, recently published in the C2/c space group, has been redetermined. The revised structure is shown to belong to the lower symmetry space group Cc and to contain additional water and acetic acid solvent molecules involved in one‐dimensional, hydrogen‐bonded chains incorporating the nitrate counterion. Accordingly, crystals obtained by means of the reported procedure should be formulated as [Fe(phen)2Cl2]NO3·CH3COOH·H2O for proper use in further experiments.
Lead isotope provinciality of central North Pacific Deep Water over the Cenozoic
Authors: Chen Tian‐Yu , Ling Hong‐Fei , Hu Rong , Frank Martin , Jiang Shao‐Yong 
Published: March 2013

AbstractUnderstanding the pre‐anthropogenic Pb cycle of central North Pacific deep water has attracted a lot of attention in recent years, partly because of its unique geographical location in that it is a remote gyre system characterized by high dust fluxes and sluggish overturning circulation. However, the factors controlling Pb isotope evolution in this area over the Cenozoic are still controversial and various mechanisms have been proposed in previous studies. Here we report new Pb and Nd isotope time series of four ferromanganese crusts (two from the western Pacific near the Mariana arc and the other two from the central Pacific). Together with previously published records, we discuss for the first time the significance of a persistent and systematic Pb isotopic provinciality recorded by central North Pacific crusts over the Cenozoic. We propose that globally well mixed stratosphere volcanic aerosols could contribute Pb but have not been the major factors controlling the Pb isotope distribution in the central North Pacific over time. Island arc input (and probably enhanced hydrothermal input between about 45 and 20 Ma) likely controlled the Pb isotope provinciality and evolution prior to ~20 Ma, when coeval Pb isotope records in different crusts showed large differences and atmospheric silicate dust flux was extremely low. After the Eocene, in particular after 20 Ma, Asian dust input has become an isotopically resolvable source, while island arc‐derived Pb has remained important to balance the dust input and to produce the observed Pb isotope distribution in the central North Pacific during this period.
Local resection of the mass to treat the osteochondroma of the mandibular condyle: Indications and different methods with 38‐case series
Authors: Chen Min‐Jie , Yang Chi , Qiu Ya‐Ting , He Dong‐Mei , Zhou Qin , Huang Dong , Shi Hui‐Min 
Published: March 2013

BackgroundLocal resection of the mass was reported to treat the condylar osteochodroma in some cases. The purpose of this study was to evaluate the feasibility and the indications of the local resection.MethodsIn all, 47 patients with osteochondroma of the mandibular condyle were treated from January 2002 to March 2012. The decision to perform local resection depended on 2 factors: there was a stalk existing between the mass and the condyle, and the condylar surface was involved less than 1/2.ResultsLocal resection of the mass was performed in 38 cases (80.1%). These masses were removed by 4 methods: direct removal (18 cases), pushed‐out by a screw and steel wire (14 cases), excision in multiple pieces (3 cases), and temporary osteotomy of the zygomatic arch (3 cases). In the follow‐up period, there was no recurrence.ConclusionLocal resection of the mass was a more conservative procedure to treat the solitary osteochondroma with a stalk. © 2013 Wiley Periodicals, Inc. Head Neck 36: 273–279, 2014
A small disturbance, but a serious disease: The possible mechanism of D52H‐mutant of human PRS1 that causes gout
Authors: Chen Peng , Li Jianzhong , Ma Jin , Teng Maikun , Li Xu 
Published: March 2013

AbstractPhosphoribosyl pyrophosphate synthetase isoform 1 (PRS1) has an essential role in the de novo and salvage synthesis of human purine and pyrimidine nucleotides. The dysfunction of PRS1 will dramatically influence nucleotides' concentration in patient's body and lead to different kinds of disorders (such as hyperuricemia, gout and deafness). The D52H missense mutation of PRS1 will lead to a conspicuous phosphoribosyl pyrophosphate content elevation in the erythrocyte of patients and finally induce hyperuricemia and serious gout. In this study, the enzyme activity analysis indicated that D52H‐mutant possessed similar catalytic activity to the wild‐type PRS1, and the 2.27 Å resolution D52H‐mutant crystal structure revealed that the stable interaction network surrounding the 52 position of PRS1 would be completely destroyed by the substitution of histidine. These interaction variations would further influence the conformation of ADP‐binding pocket of D52H‐mutant and reduced the inhibitor sensitivity of PRS1 in patient's body. © 2013 IUBMB Life, 65(6):518–525, 2013.
Characterization of protein release from poly(ethylene glycol) hydrogels with crosslink density gradients
Authors: Bal Tuğba , Kepsutlu Burcu , Kizilel Seda 
Published: March 2013

AbstractTransplantation of cells within poly(ethylene glycol) (PEG) hydrogel scaffolds as effective immunoisolation barriers is becoming increasingly important strategy for tissue engineering and regenerative medicine. In these applications, crosslink density of these membranes has significant effect on the control of diffusion of many biomolecules such as nutrients, cellular wastes, and hormones. When these networks are designed with crosslink density gradients, alterations in network structure may have an effect on biomolecule diffusivity. The goal of this work was to synthesize PEG hydrogels via surface initiated photopolymerization for use in applications involving physiological protein delivery and cell encapsulation. For this purpose, PEG hydrogels of differing crosslink density gradients were formed via surface initiated photopolymerization, and the diffusion of model proteins with various molecular weights were observed through these PEG hydrogel scaffolds with defined properties. Diffusion coefficients were on the order of 10−7−10−8 cm2/s and protein diffusion time scales varied from 5 min to 30 h. The results confirm that synthetic PEG hydrogels with crosslink density gradients are promising for controlled release of bioactive molecules and for covalent incorporation of ligands to support cell viability. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 487–495, 2014.