bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre‐impoundment stock assessment of two Pimelodidae species caught by small‐scale fisheries in the Madeira River (Amazon Basin – Brazil)
Authors: Sant'Anna I. R. A. , Doria C. R. C. , Freitas C. E. C. 
Published: May 2014

AbstractThe middle stretch of the Madeira River has supported an intensive commercial fishery for several decades. Developed in an area of rapids and waterfalls, this fishery focuses primarily on catfish stocks, mainly pimelodids. Data from fish landings collected in the years immediately prior to the start in operations of two large hydroelectric dams were used to estimate growth and mortality rates for Pirinampus pirinampu (Spix & Agassiz) and Brachyplatystoma platynemum Boulenger. In addition, stock assessment was carried out for both species, and the results used to evaluate the status of the fishery. Mean population parameters were L∞ = 80.85 cm (total length), k = 0.52 year−1, ϕ = 3.53, A0.95 = 6 year, M = 0.87, F = 1.41–1.64 and Z = 2.28–2.51 for P. pirinampu; and L∞ = 95.55 cm (total length), k = 0.28 year−1, ϕ = 3.40, winter point = 0.41, A0.95 = 11 year, M = 0.55, F = 0.16–0.35 and Z = 0.71–0.90 for B. platynemum. Yield‐per‐recruit analysis indicated P. pirinampu was overfished and that the stock of B. platynemum was under‐exploited. Moreover, overfishing of the P. pirinampu stock and the effects of fragmentation caused by the construction of the dam should be monitored.
Concomitant Persistent Pain in Classical Trigeminal Neuralgia – Evidence for Different Subtypes
Authors: Maarbjerg Stine , Gozalov Aydin , Olesen Jes , Bendtsen Lars 
Published: May 2014

ObjectiveTo describe the clinical characteristics in classical trigeminal neuralgia (TN) with concomitant persistent pain and to investigate whether TN with concomitant persistent pain represents a distinct phenotype.BackgroundThere has been much debate about the possible pathophysiological and clinical importance of concomitant persistent pain in TN. This has led to subgrouping of TN into forms with and without concomitant persistent pain in the recent 3rd International Classification of Headache Disorders beta classification.MethodsIn this cross‐sectional study, data on the clinical characteristics were systematically and prospectively collected from consecutive TN patients.ResultsA total of 158 consecutive TN patients were included. Concomitant persistent pain was present in 78 patients (49%). The average intensity of concomitant persistent pain was 4.6 (verbal numerical rating scale). The concomitant persistent pain was present at onset or early in the disease course. Patients with concomitant persistent pain were on average 6.2 (P = .008) years younger at onset, but the 2 groups had the same duration of disease (P = .174). There was a preponderance of women in TN with (P < .001) but not in TN without concomitant persistent pain (P = .820). Right‐sided pain was more prevalent than left‐sided in TN without (P = .007) but not in TN with concomitant persistent pain (P = .907). TN with concomitant persistent pain more frequently had sensory abnormalities (P < .001) and less frequently responded to sodium channel blockers (P = .001). There were no significant differences in other clinical characteristics.ConclusionsConcomitant persistent pain is very prevalent in TN and is not a consequence of paroxysmal pain. Findings support that the 3rd International Classification of Headache Disorders beta division of TN with and without concomitant persistent pain is clinically and scientifically important.
Migratory connectivity of Palaearctic–African migratory birds and their responses to environmental change: the serial residency hypothesis
Authors: Cresswell Will 
Published: May 2014

In most long‐distance migratory birds, juveniles migrate without their parents and so are likely to lack detailed knowledge of where to go. This suggests the potential for stochasticity to affect their choice of wintering area at a large scale (> 1000 km). Adults, in contrast, may re‐use non‐breeding sites that promote their survival, so removing uncertainty from their subsequent migrations. I review the evidence for large‐scale stochastic juvenile site selection followed by adult site fidelity, and then develop a ‘serial‐residency’ hypothesis based on these two traits as a framework to explain both the migratory connectivity and the population dynamics of migrant birds and how these are affected by environmental change. Juvenile stochasticity is apparent in the age‐dependent effects of weather or experimental displacement on the outcome of migration and in the very wide variation in the destinations of individuals originating from the same area. Adults have been shown to be very faithful to their wintering grounds and even to staging sites. The serial residency hypothesis predicts that migrants that show these two traits will rely on an individually unique but fixed series of temporally and spatially linked sites to complete their annual cycle. As a consequence, migratory connectivity will be apparent at a very small scale for individuals, but only at a large scale for a population, and juveniles are predicted to occur more often at less suitable sites than adults, so that survival will be lower for juveniles. Migratory connectivity will arise only through spatial and temporal autocorrelation with local environmental constraints, particularly on passage, and the distribution and age structure of the population may reflect past environmental constraints. At least some juveniles will discover suitable habitat that they may re‐use as adults, thus promoting overall population‐level resilience to environmental change, and suggesting value in site‐based conservation. However, because migratory connectivity only acts on a large scale, any population of migrants will contain individuals that encounter a change in suitability somewhere in their non‐breeding range, so affecting average survival. Differences in population trends will therefore reflect variation in local breeding output added to average survival from wintering and staging areas. The latter is likely to be declining given increasing levels of environmental degradation throughout Africa. Large‐scale migratory connectivity also has implications for the evolutionary ecology of migrants, generally because this is likely to lead to selection for generalist traits.
An evaluation of an intervention designed to improve the evidence-based supply of non-prescription medicines from community pharmacies
Authors: Ngwerume Karebor , Watson Margaret , Bond Christine , Blenkinsopp Alison 
Published: May 2014

Abstract

Objectives
The aims of this study were to conduct the proof of concept study and to develop and evaluate an educational intervention that promotes the evidence-based supply of non-prescription medicines (NPMs).

Method
An educational intervention was delivered to pharmacy assistants and pharmacists in three pharmacies in England. The intervention included the provision of summaries of evidence for the treatment of four minor ailments and resulted in the preparation of evidence-based portfolios for the treatment of the following ailments: athlete's foot, cough, nasal congestion and period pain. The effect of the intervention was evaluated using a combination of direct overt observation, vignettes, self-reported behaviour and interviews.

Key findings
Evaluation data were collected from the three pharmacies. Data were derived from 3 pharmacists and 13 assistants, of whom 10 (3 pharmacists; 7 assistants) attended the training event. Comparing pre- and post-intervention practice, 8/11 (pre-) versus 5/6 (post-) observed, 46/80 versus 62/80 vignette and 25/30 versus 39/40 self-reported recommendations were evidence based. Prior to the intervention, 3/16 participants understood the role of evidence regarding the supply of NPMs compared with 16/16 post-intervention. Participants reported relying upon experiential knowledge to inform their decision making prior to the educational intervention. Thereafter, the participants reported using evidence to a greater extent. Barriers and facilitators for evidence-based practice were also identified.

Conclusion
A one-off educational intervention increased participants' self-reported awareness and potential application of evidence to inform their supply of NPMs. Further research is needed to assess the effectiveness, long-term impact, generalisability and cost-effectiveness of this intervention for a wider range of common conditions.
Islamist terrorism as identity threat: the case of ambivalent identification and self‐stereotyping among Turkish Muslims
Authors: Uz Irem , Kemmelmeier Markus 
Published: May 2014

AbstractTerrorist attacks committed in 2003 by Turkish Islamist extremists threatened the social identity of Turkish Muslims by associating them with terrorism. Using a 2 × 3 experimental design, we categorized Turkish respondents and terrorists as members of a shared superordinate group (“Muslims”) or as members of separate subgroups. When sharing superordinate group membership with terrorists, less identified Turkish respondents experienced ambivalent identification, i.e., they sought to maintain attachment to their group while simultaneously seeking distance from it. Ambivalent identification was reduced when respondents emphasized their typicality as members of a Muslim subgroup that did not include terrorists. The discussion focuses on ambivalent identification as a response to identity threat, and the implications for Islamist terrorism for the social identity of Muslims.
Can appraisals of common political life events impact subjective well‐being?
Authors: Kaniasty Krzysztof , Jakubowska Urszula 
Published: May 2014

AbstractThis study examined the psychological impact of global subjective appraisals of influence exerted on people's lives by common political events. A list of 24 political events was administered to a random sample of 400 adults in Poland. Political self‐efficacy, interest in politics, perceived political social support, and political collective efficacy were also assessed as potential moderators of the link between political stress appraisals and subjective well‐being (satisfaction with life, sense on anomie, positive affect). Perceptions of the negative influence of political stressors on one's life and the life of the country were associated with concomitant variations in subjective well‐being. Among psychosocial resources, political self‐efficacy consistently moderated the influence of appraisals of political stressors on satisfaction with life and positive affect.
Modeling type 2 diabetes in rats using high fat diet and streptozotocin
Authors: Skovsø Søs 
Published: May 2014

AbstractThe pathology of type 2 diabetes is complex, with multiple stages culminating in a functional β‐cell mass that is insufficient to meet the body's needs. Although the broad outlines of the disease etiology are known, many critical questions remain to be answered before next‐generation therapeutics can be developed. In order to further elucidate the pathobiology of this disease, animal models mimicking the pathology of human type 2 diabetes are of great value. One example of a type 2 diabetes animal model is the high‐fat diet‐fed, streptozotocin (HFD/STZ)‐treated rat model. The present review first summarizes the current understanding of the metabolic profile and pathology involved in the different stages of the type 2 diabetes disease progression in humans. Second, the known characteristics of the HFD/STZ rat model are reviewed and compared with the pathophysiology of human type 2 diabetes. Next, the suitability of the HFD/STZ model as a model of type 2 diabetes with a focus on identifying critical caveats and unanswered questions about the model is discussed. The improved understanding of refined animal models will hopefully lead to more relevant preclinical studies and development of improved therapeutics for diabetes. Depending on the amount of residual functional β‐cells mass, the HFD/STZ rat model might be a suitable animal model of the final stage of type 2 diabetes.
Staphylococcal scalded skin syndrome: diagnosis and management in children and adults
Authors: Handler M.Z. , Schwartz R.A. 
Published: May 2014

AbstractStaphylococcal scalded skin syndrome is a potentially life‐threatening disorder caused most often by a phage group II Staphylococcus aureus infection. Staphylococcal scalded skin syndrome is more common in newborns than in adults. Staphylococcal scalded skin syndrome tends to appear abruptly with diffuse erythema and fever. The diagnosis can be confirmed by a skin biopsy specimen, which can be expedited by frozen section processing, as staphylococcal scalded skin syndrome should be distinguished from life threatening toxic epidermal necrolysis. Histologically, the superficial epidermis is detached, the separation level being at the granular layer. The diffuse skin loss is due to a circulating bacterial exotoxin. The aetiological exfoliating toxin is a serine protease that splits only desmoglein 1. The exfoliative toxins are spread haematogenously from a localized source of infection, causing widespread epidermal damage at distant sites. Sepsis and pneumonia are the most feared complications. The purpose of this review is to summarize advances in understanding of this serious disorder and provide therapeutic options for both paediatric and adult patients. Recent epidemiological studies have demonstrated that paediatric patients have an increased incidence of Staphylococcal scalded skin syndrome during the summer and autumn. Mortality is less than 10% in children, but is between 40% and 63% in adults, despite antibacterial therapy. Previously, intravenous immunoglobulin had been recommended to combat Staphylococcal scalded skin syndrome, but a recent study associates its use with prolonged hospitalization.
Prospective differentiation of clinically difficult to distinguish nodular basal cell carcinomas and intradermal nevi by non‐invasive Reflectance Confocal Microscopy: a case series study
Authors: Hoogedoorn L. , Peppelman M. , Blokx W.A.M. , van Erp P.E.J. , Gerritsen M.‐J. P. 
Published: May 2014

AbstractBackgroundClinical differentiation between a nodular basal cell carcinoma (nBCC) and a benign intradermal nevus can be difficult. Even with additional dermoscopic evaluation, a correct diagnosis may be difficult. Currently, histopathological examination of a biopsy is the gold standard to differentiate between these lesions. However, this is an invasive technique and sampling errors can occur. In vivo Reflectance Confocal Microscopy (RCM) is a non‐invasive technique to evaluate a skin lesion at a microscopic level. RCM features of nBCCs and intradermal nevi have been described in research setting. However, the use of RCM for prospective differentiation between difficult to diagnose nodules into nBCCs and intradermal nevi in clinical practice has not been demonstrated yet.ObjectiveIn this study, we aim to address a common clinical scenario; to differentiate clinically and dermoscopically difficult to distinguish nodules, into nBCCs and intradermal nevi by RCM.Material and methodsSix patients with clinically and dermoscopically difficult to distinguish nodular skin lesions were evaluated by RCM to differentiate prospectively between nBCCs and intradermal nevi. In five out of six cases, a 3 mm punch biopsy was obtained to confirm the RCM diagnosis.ResultsObserved RCM features that allowed differentiation between nBCCs and intradermal nevi were the dermal–epidermal junction patterns, the appearance of the nests and the degree of vascularization.ConclusionsThis case series study demonstrates the value of non‐invasive in vivo RCM imaging in routine patient care, with respect to the prospective diagnosis of clinically difficult to distinguish nBCCs and intradermal nevi. Subsequently, biopsies of benign lesions in cosmetic areas could be avoided.
Clinical relevance of immunogenicity of biologics in psoriasis: Implications for treatment strategies
Authors: Carrascosa J.‐M. , van Doorn M.B.A. , Lahfa M. , Nestle F.O. , Jullien D. , Prinz J.C. 
Published: May 2014

AbstractBiological drugs such as the tumour necrosis factor inhibitors have revolutionized the treatment of psoriasis, but some have the potential to induce an unwanted immune response. This immunogenicity may be associated with low trough drug levels, reduced clinical efficacy, reduced drug survival and an increased risk for adverse events. This article presents a literature review of the evidence on immunogenicity of biologics used in the treatment of psoriasis and considers the implications for therapeutic decision‐making in the management of patients with moderate‐to‐severe psoriasis.
Influence of thermal conditions on habitat use by a rare spring‐emerging butterfly Euphydryas editha taylori
Authors: Bennett V. J. , Betts M. G. , Smith W. P. 
Published: May 2014

AbstractWe may expect butterflies as ectotherms to have particularly active life‐history stages that occur in the warmest and lightest times of the year; however, there are temperate species that are active when climatic conditions seem unfavourable and photoperiod short, such as the Taylor's checkerspot (Euphydryas editha taylori). For such species, studies suggest that even subtle changes to microclimate can potentially impact populations. Thus, understanding how in situ variations in microclimate influence the Taylor's checkerspot butterfly could provide much needed insights into more effective management. We conducted a series of surveys that explored (i) adult habitat use, (ii) final instar larval distribution and (iii) adult movement up to and across site boundaries at two sites in Oregon, USA, in 2010 and 2011. We found that in situ habitat use by the Taylor's checkerspot butterfly was strongly influenced by microclimate. Both adult activities and final instar larvae distribution were clustered within the warmest areas of the sites. Moreover, adults did not use up to 59% and larva up to 90% of their sites, despite vegetation structure and composition being uniform. More specifically, butterfly habitat use increased with increasing ground temperatures, and we found that areas with the highest ground temperatures were more exposed to direct sunlight. Similarly, we found that butterflies tended to only move through sunlit site boundaries. We conclude that the Taylor's checkerspot is sensitive to changes in its thermal environment at fine spatial scales. Our results highlight the importance of microclimate as an indicator of habitat quality, and establishing the thermal criteria in which species of concern exists may provide valuable insights into the implications of climate change.
Feasibility study for the introduction of a new treatment method for benign thyroid nodules in a teaching and research hospital
Authors: Longo Marcella , Cassoli Ing Paolo , Fugazzola Laura , Vannucchi Guia , Lanzoni Monica , Castaldi Silvana 
Published: May 2014

AbstractRationale, aims and objectivesNumerous scientific publications have confirmed that percutaneous laser thermal ablation (LTA) represents a possible therapeutic option in selected patients with benign thyroid nodules. A study was carried out to evaluate the feasibility of adopting the LTA technique to treat benign thyroid nodules in a teaching and research hospital in northern Italy.MethodsA cost analysis from a company's perspective determined the impact of adoption of the new technique on the overall Hospital budget, considering currently available equipment, infrastructure and personnel, equipment costs and treatment tariffs.ResultsThe cost analysis shows that, strictly from an economic point of view, any provision of the LTA technique will result as a loss on the Hospital's balance sheet. However, it does not estimate the extent of the impact on the overall budget because it did not evaluate the savings that such a technique would make with respect to alternative therapeutic treatments. Therefore, the Hospital policy management decided to extend the current agreement with a private authorized health care structure that already carries out LTA. Also, although difficult to express in economic terms, this new technique would undoubtedly raise the profile and enhance the reputation of the Hospital.ConclusionsUsing the new technique in these patients could cut costs for the entire regional health care system, widen the experience of the Hospital's endocrinology team and offer the potential for the procedure also to be provided by operators on a freelance basis within the Hospital.
Problems related to antifungal prescription: a qualitative study of the views of intensivists
Authors: Salci Tânia Pereira , Batilana Adelia P. , Pietrobon Ricardo , Caparroz‐Assef Silvana Martins 
Published: May 2014

AbstractRationale and objectiveThe choice of the appropriate antifungal medication is essential for therapeutic success. Although guidelines are available in the literature that regulate the consistent use of antifungal, no previous qualitative studies have addressed the difficulties related to the use of antifungal medication, especially in the intensive care unit (ICU). Our objective was to qualitatively investigate how intensivists consider antifungal prescriptions in an adult ICU.MethodsThe Grounded Theory analytical method was used for the data analysis. Physicians who worked in the adult ICU and prescribed antifungal medications were individually interviewed. A semi‐structured interview was used to ask core questions, followed by follow‐up questions at the discretion of the interviewer.ResultsOur analysis generated eight main emerging themes that were classified into three related groups. The main insights were that various interconnected reasons were given for the lack of conformity with regard to prescription patterns for antifungals. A negative cycle was perceived based on issues related to prescriptions and the search for knowledge. If problems related to individual actions and multidisciplinary team integration are resolved and local protocols are implemented based on local epidemiology, then barriers to proper prescriptions can be overcome when intensivists are faced with the unusual practice of prescribing antifungals.ConclusionsOur investigation indicates the need for prescription assistance with support from a well‐trained multidisciplinary team and consensus among its members and the importance of well‐designed protocols.