bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constantine: configurable static analysis tool in Eclipse
Authors: Gawade Makarand , Ravikanth K. , Aggarwal Sanjeev 
Published: December 2012

SUMMARYStatic code analysers help in exposing internal code quality problems. For higher effectiveness, they must be pressed into use early during the development of code. They must support the formulation of new coding constraints with relative ease to better cope with variations in coding standards. We present the design of a static analyser that addresses these twin objectives. Our system provides interactive feedback to programmers on the non‐conformances that occur in response to the changes made to the code. Its rule construction framework empowers programmers to define new conformance rules, which can come into effect immediately after creation. The tool has been realized as an Eclipse plug‐in for the analysis of C, C++ and Java sources. Central to its design is the concept of reusing a set of primitive checks by composing them to form new rules. This renders rule construction accessible to programmers, lowers dependence on tool smiths and accelerates the enforcement of custom checks. We also present our experience in defining rules drawn from an industry standard rule set based on this approach. Copyright © 2012 John Wiley & Sons, Ltd.
Conditional Induction of Math1 Specifies Embryonic Stem Cells to Cerebellar Granule Neuron Lineage and Promotes Differentiation into Mature Granule Neurons
Authors: Srivastava Rupali , Kumar Manoj , Peineau Stéphane , Csaba Zsolt , Mani Shyamala , Gressens Pierre , El Ghouzzi Vincent 
Published: December 2012

Abstract
Directing differentiation of embryonic stem cells (ESCs) to specific neuronal subtype is critical for modeling disease pathology in vitro. An attractive means of action would be to combine regulatory differentiation factors and extrinsic inductive signals added to the culture medium. In this study, we have generated mature cerebellar granule neurons by combining a temporally controlled transient expression of Math1, a master gene in granule neuron differentiation, with inductive extrinsic factors involved in cerebellar development. Using a Tetracyclin-On transactivation system, we overexpressed Math1 at various stages of ESCs differentiation and found that the yield of progenitors was considerably increased when Math1 was induced during embryonic body stage. Math1 triggered expression of Mbh1 and Mbh2, two target genes directly involved in granule neuron precursor formation and strong expression of early cerebellar territory markers En1 and NeuroD1. Three weeks after induction, we observed a decrease in the number of glial cells and an increase in that of neurons albeit still immature. Combining Math1 induction with extrinsic factors specifically increased the number of neurons that expressed Pde1c, Zic1, and GABAα6R characteristic of mature granule neurons, formed “T-shaped” axons typical of granule neurons, and generated synaptic contacts and action potentials in vitro. Finally, in vivo implantation of Math1-induced progenitors into young adult mice resulted in cell migration and settling of newly generated neurons in the cerebellum. These results show that conditional induction of Math1 drives ESCs toward the cerebellar fate and indicate that acting on both intrinsic and extrinsic factors is a powerful means to modulate ESCs differentiation and maturation into a specific neuronal lineage.
Injectable Bone Tissue Engineering Using Expanded Mesenchymal Stem Cells
Authors: Yamada Yoichi , Nakamura Sayaka , Ito Kenji , Umemura Eri , Hara Kenji , Nagasaka Tetsuro , Abe Akihiro , Baba Shunsuke , Furuichi Yasushi , Izumi Yuichi , Klein Ophir D. , Wakabayashi Toshihiko 
Published: December 2012

Abstract
Patients suffering from bone defects are often treated with autologous bone transplants, but this therapy can cause many complications. New approaches are therefore needed to improve treatment for bone defects, and stem cell therapy presents an exciting alternative approach. Although extensive evidence from basic studies using stem cells has been reported, few clinical applications using stem cells for bone tissue engineering have been developed. We investigated whether injectable tissue-engineered bone (TEB) composed of mesenchymal stem cells (MSCs) and platelet-rich plasma was able to regenerate functional bone in alveolar deficiencies. We performed these studies in animals and subsequently carried out large-scale clinical studies in patients with long-term follow-up; these showed good bone formation using minimally invasive MSC transplantation. All patients exhibited significantly improved bone volume with no side effects. Newly formed bone areas at 3 months were significantly increased over the preoperation baseline (p &lt; .001) and reached levels equivalent to that of native bone. No significant bone resorption occurred during long-term follow-up. Injectable TEB restored masticatory function in patients. This novel clinical approach represents an effective therapeutic utilization of bone tissue engineering.
Atomic Layer Deposition
Authors: Pimenoff Joe 
Published: December 2012

AbstractAtomic layer deposition, ALd, is a thin film deposition technology that enables new and highly competitive products. As a disruptive technology, it can often replace existing production technology and improve throughput, coating quality and sometimes process sustainability. ALd is also a powerful resource for advanced nanotechnology research.Today's industrial applications of ALd habitually address a concrete requirement to manufacture precise nanometer–thick, dense and pinhole–free conformal thin films of exact chemical composition on various shapes and geometries. For today's businesses, ALd and Beneq offer the necessary tools to enable growth, by means of new and innovative applications, reliable production equipment and attractive cost of ownership.
Plasmatechnische Werkzeuge der Medizintechnik
Authors: Klinkenberg Ernst‐Dieter , Neumann Hans‐Georg 
Published: December 2012

AbstractDer Gelenkersatz durch eine Endoprothese stellt heute eine Standardtherapie dar. Die Plasmatechnologie leistet wesentliche Beiträge zur Oberflächengestaltung moderner Implantate. Zur erfolgreichen Entwicklung von langlebigen Implantaten ist eine multidisziplinäre Zusammenarbeit unabdingbar.
Wälzlager in der Vakuumtechnik
Authors: Marquart Matthias , Sauer Bernd 
Published: December 2012

AbstractDer Einsatz von Wälzlagern im Vakuum wird vor allem durch technische Grenzen herkömmlicher Schmierstoffe behindert. Möglichkeiten, dieses Maschinenelement dennoch in diesen Umgebungen einzusetzen, gibt es. Hierzu wird z.B. ein alternatives Schmiersystem, bestehend aus Molybdändisulfid, erfolgreich appliziert. In der Folge lassen sich Wälzlager sowohl bei hohen Temperaturen wie auch im Vakuum betreiben. Nachfolgend wird dargelegt, wie eine Lebensdauerabschätzung erfolgen kann. Weiter wird gezeigt, mit welchen Mitteln eine Optimierung hinsichtlich Laufzeit und damit auch den Kosten des Maschinenelements Wälzlager in diesen extremen Einsatzgebieten umgesetzt wird. Die dabei genannten Maßnahmen werden anhand von experimentellen Untersuchungen belegt.
Correction: Sind Trockenläufer wirklich die Lösung aller Probleme?
Authors: Barfuss Heinz 
Published: December 2012

AbstractAus technischen Gründen fehlten in der letzten Ausgabe dieser Zeitschrift Teile dieses Beitrags. Wir bitten dies zu entschuldigen. Der Einfachheit halber drucken wir hier nun den kompletten Beitrag.Mit diesem Artikel versucht der Autor aufzuzeigen, daß Trockenläufer nicht in allen Anwendungen aufgrund des Pumpprinzips, der Saugvermögenscharakteristik und auch physikalischen Grenzen die Lösung aller vakuumtechnischen Herausforderungen sind. Aufwendige Überwachungs‐ und Schutzmaßnahmen machen den Betrieb anfälliger, erhöhen die Betriebs‐ und Wartungskosten und stellen gegenüber den klassischen Drehschieberpumpen deutlich höhere Anforderungen an die Systemhersteller und Betreiber. Die Notwendigkeit der Ölfreiheit im Schöpfraum und der Prozesskammer oder Apparatur hat die Entwicklung der Trockenläufer entscheidend vorangetrieben, jedoch ist die Drehschieberpumpe auch weiterhin in bestimmten Anwendungen die Pumpe der Wahl.
Comparative Genomics of the Lipid-Body-Membrane Proteins Oleosin, Caleosin and Steroleosin in Magnoliophyte, Lycophyte and Bryophyte
Authors: Umate Pavan 
Published: December 2012

Abstract
Lipid bodies store oils in the form of triacylglycerols. Oleosin, caleosin and steroleosin are unique proteins localized on the surface of lipid bodies in seed plants. This study has identified genes encoding lipid body proteins oleosin, caleosin and steroleosin in the genomes of five plants: Arabidopsis thaliana, Oryza sativa, Populus trichocarpa, Selaginella moellendorffii and Physcomitrella patens. The protein sequence alignment indicated that each oleosin protein contains a highly-conserved proline knot motif, and proline knob motif is well conserved in steroleosin proteins, while caleosin proteins possess the Dx[D/N]xDG-containing calcium-binding motifs. The identification of motifs (proline knot and knob) and conserved amino acids at active site was further supported by the sequence logos. The phylogenetic analysis revealed the presence of magnoliophyte- and bryophyte-specific subgroups. We analyzed the public microarray data for expression of oleosin, caleosin and steroleosin in Arabidopsis and rice during the vegetative and reproductive stages, or under abiotic stresses. Our results indicated that genes encoding oleosin, caleosin and steroleosin proteins were expressed predominantly in plant seeds. This work may facilitate better understanding of the members of lipid-body-membrane proteins in diverse organisms and their gene expression in model plants Arabidopsis and rice.
Atrial tachycardia in a patient with arrhythmogenic right ventricular cardiomyopathy/dysplasia
Authors: Mano Hiroaki , Watanabe Ichiro , Okumura Yasuo , Sonoda Kazumasa , Nagashima Koichi , Nakai Toshiko , Ohkubo Kimie , Kofune Tatsuya , Haruta Hironori , Kofune Masayoshi , Kunimoto Satoshi , Hirayama Atsushi 
Published: December 2012

AbstractWe describe a 49‐year‐old woman with atrial tachycardia (AT) and arrhythmogenic right ventricular cardiomyopathy/dysplasia. Cardiac magnetic resonance images showed a markedly dilated right atrium and right ventricle. Electroanatomical mapping showed that the AT originated from the right atrial appendage.
Dietary fibre consumption and insulin resistance – the role of body fat and physical activity
Authors: Breneman Charity B. , Tucker Larry 
Published: December 2012

The present study was conducted to determine the association between fibre intake and insulin resistance in 264 women using a cross-sectional design. Insulin resistance was indexed using homeostasis model assessment of insulin resistance (HOMA-IR) (US formula: fasting insulin (μU/ml) × fasting glucose (mg/dl)/405 international formula: fasting glucose (mmol/l) × fasting insulin (μU/l)/22.5). Fibre and energy consumption were assessed using 7 d weighed food records. Fibre was expressed as g/4184 kJ (1000 kcal). Body fat percentage (BF%) was measured using the BOD POD, and physical activity (PA) was ascertained using Actigraph accelerometers (Health One Technology) worn for seven consecutive days. Women with high total fibre intakes (F= 4·58, P= 0·0332) or high soluble fibre intakes (F= 7·97, P= 0·0051) had significantly less insulin resistance than their counterparts. Participants with high insoluble fibre intakes did not differ from their counterparts (F= 0·7, P= 0·6875). Adjusting for either PA or BF% weakened the relationships significantly. Controlling for BF% nullified the total fibre–HOMA-IR link (F= 1·96, P= 0·1631) and attenuated the association between soluble fibre and HOMA-IR by 32 % (F= 6·86, P= 0·0094). To create dichotomous variables, fibre intake and HOMA-IR were each divided into two categories using the median (low and high). In women who had high soluble fibre intake (upper 50 %), the OR of having an elevated HOMA-IR level was 0·58 (95 % CI 0·36, 0·94) times that of women with low soluble fibre intake (lower 50 %). After controlling for all of the potential confounding factors simultaneously, the OR was 0·52 (95 % CI 0·29, 0·93). High fibre intake, particularly soluble fibre, is significantly related to lower levels of insulin resistance in women. Part of this association is a function of differences in PA and BF%.
Influence of cultivar, sowing date and maturity at harvest on yield, digestibility, rumen fermentation kinetics and estimated feeding value of maize silage
Authors: OPSI F. , FORTINA R. , BORREANI G. , TABACCO E. , LÓPEZ S. 
Published: December 2012

SUMMARYTwo maize hybrid cultivars, early (Cisko FAO 300) and late maturing (Arma FAO 700), were sown on three different dates (March, April or May) and harvested at two stages of maturity (kernel milk line (ML) scores of 1/4 < ML < 1/3 or 1/2 < ML < 2/3) in the western Po plain (Italy) in 2008. Yield, chemical composition andin vitrodigestibility and fermentation kinetics of pre-ensiled whole-crop maize and of silage were measured. Cultivar and sowing date influenced the dry matter (DM) yield of whole-plant maize, with DM yield being 40% higher in Arma than in Cisko, and DM yield decreasing with later sowing dates. Later maturity increased DM concentration at harvest for both hybrids, due to differences in kernel development. The neutral detergent fibre (NDF) content declined and starch increased as plants matured. Digestibility was estimatedin vitrofollowing the Ankom procedure. Rate and extent of ruminal degradation were estimated from gas production (GP) profiles during incubation in diluted rumen fluid. Cultivar, planting date and maturity had no effect onin vitroDM digestibility of pre-ensiled whole-crop maize, but following 240 days of ensiling significant differences between cultivars in digestibility were detected. GP kinetic parameters differed between cultivars for pre-ensiled whole-crop maize, with Cisko having higher asymptotic GP but lower fractional fermentation rates and longer lag times than the Arma hybrid. GP volumes were greater as sowing or harvest dates were delayed. Energy value and milk production were estimated using the Milk2006 Model. With the pre-ensiled whole-crop maize, a 38% greater milk yield/ha was expected with Arma than with Cisko, matching the 40% greater DM yield. The same trend was observed in maize silage, where cultivar and planting date affected milk production/ha, with greater values for Arma than for Cisko and lower values for the latest planting date. Optimal management practices, including decision making on planting and harvest time and hybrid cultivar selection, can influence the yield and nutritive value of maize silage.
Current concepts and advances in the application of tissue engineering in otorhinolaryngology and head and neck surgery
Authors: Sivayoham E , Saunders R , Derby B , Woolford T 
Published: December 2012

AbstractObjective:This paper reviews the progress in the rapidly expanding scientific discipline of tissue engineering, which may have an integral role in the future of otorhinolaryngology. This article seeks to inform on the current concepts and principles of tissue engineering, and describe the state of the art research and developments in this exciting field as applied to ENT and head and neck surgery.Method:In order to carry out a comprehensive review of the literature spanning the past 30 years, a search of relevant publications was performed using the Web of Knowledge, Medline and PubMed databases.Results:This search identified 85 scholarly articles, which were utilised as the basis of this review.Conclusion:Given the current rate of development of tissue engineering research, it is likely that tissue-engineered implants will be widely used in surgical practice, including ENT and head and neck surgery.
Vibrant Soundbridge system: application of the stapes coupling technique
Authors: Tsang W S S , Yu J K Y , Wong T K C , Tong M C F 
Published: December 2012

AbstractIntroduction:The use of the stapes coupling technique, employed in the Vibrant Soundbridge system, is technically less demanding than the vibroplasty technique, and is more likely to generate a positive outcome without significantly changing residual hearing or resulting in medical or surgical complication.Method:We report a patient with repeated left ossiculoplasty failure, who was successfully implanted with a Vibrant Soundbridge.Conclusion:We believe that the stapes coupling technique can provide natural stimulation to the inner ear, resulting in a better perceived sound quality.
Unusual presentation of cervical spine metastases to the ENT surgeon
Authors: Baruah P , Randall C J , Burgess A 
Published: December 2012

AbstractObjective:Cervical spine metastases account for 10 per cent of all spinal metastases. We report three cases of cervical spine metastases whose unusual primary presentation was with ENT-related symptoms.Methods:The three patients reported herein did not have a confirmed diagnosis of malignancy at presentation. The first patient presented with stridor, the second presented with dysphagia and the third presented with dysphonia. All patients complained of significant neck pain that preceded and was concomitant to the other symptoms. Clinical suspicion of cervical spine involvement led to radiological investigation with computed tomography, which showed metastatic lesions in the craniovertebral junction and cervical spine region. Histological confirmation of malignancy was obtained for two of the three patients. The condition proved uniformly fatal in the weeks following diagnosis. A review of the literature on this condition was conducted using PubMed and Medline databases.Conclusion:Cervical spine pathology may present initially to the ENT surgeon. A high degree of suspicion of cervical spine involvement should be maintained in elderly patients with persistent or progressive neck pain, with or without other ENT symptoms. Adequate radiological imaging will usually confirm the diagnosis.
The use of GlideScope for biopsies of the tongue base
Authors: Shenoy P K , Aldea M 
Published: December 2012

AbstractObjective:To report a case where GlideScope® is used for the biopsy of the tongue base.Background:GlideScopes are used by anaesthetists for difficult intubations.Case report:This paper reports a case where a GlideScope was used for biopsy of the tongue base. A review of the literature indicated that this was the first time a GlideScope had been utilised for this purpose.Conclusion:It is suggested that this is a safe and ideal technique for biopsy of the tongue base, and GlideScopes could be used more frequently for this purpose in the future.
Chondrodermatitis nodularis chronica helicis excision and reconstruction
Authors: Yaneza M M C , Sheikh S 
Published: December 2012

AbstractBackground:Chondrodermatitis nodularis chronica helicis is a common benign condition of the pinna. It presents as a painful, well demarcated nodule on the pinna that may be associated with surrounding erythema or an overlying crust.Methods:This paper describes techniques for the excision of chondrodermatitis nodularis chronica helicis on both the helix and anti-helix, and reconstruction of the defect.Conclusion:Both methods give an excellent cosmetic result and can be performed under local anaesthetic. Excising and smoothing down the cartilage decreases the likelihood of recurrence as a smooth contour to the ear is achieved.
Young systemic lupus erythematosus patients with no hearing involvement: 10-year follow up
Authors: García-Berrocal J R , De Diego B , Roldán-Fidalgo A , Yebra-Bango M , Millán I , Trinidad A , Ramírez-Camacho R 
Published: December 2012

AbstractObjective:To evaluate patients with systemic lupus erythematosus and normal hearing over 10 years, compared with healthy controls.Methods:Thirty patients diagnosed with systemic lupus erythematosus were evaluated in a prospective, descriptive study. Eight patients fulfilled the inclusion criteria, i.e. normal otoscopy, normal hearing, normal imaging and disease duration of less than one year. Eleven healthy companions of ENT patients were recruited as controls.Results:At study commencement, the mean patient age was 32.75 years (range, 15–49 years) and there were no statistically significant audiometric differences between patients and controls. No statistically significant audiometric changes were found either within or between the patient and control groups at 10-year follow up.Conclusion:These results supply no evidence for progressive hearing loss in systemic lupus erythematosus patients with no hearing involvement at study commencement. Therefore, we recommend audiometric tests only for systemic lupus erythematosus patients complaining of hearing loss, or for other clinical purposes. It is conceivable that asymptomatic hearing loss could be observed over a more extended follow-up period (i.e. more than 10 years).
Extensive pneumocephalus extending into the lateral ventricles from a brain abscess: an intracranial complication of cholesteatoma
Authors: Tamura Y , Suzuki M , Yamamoto M , Yoshida T 
Published: December 2012

AbstractObjective:We report the case of a patient with extensive pneumocephalus extending into the lateral ventricles from a brain abscess arising from a cholesteatoma-induced defect in the skull base.Case report:A 70-year-old man with cholesteatoma presented with right-sided otalgia, otorrhoea and progressive headaches. Computed tomography showed a tegmental defect (approximately 2 × 2 cm) at the right mastoid antrum. A T1-weighted, gadolinium-enhanced magnetic resonance imaging scan showed pneumocephalus in both lateral ventricles, which was directly connected to the mastoid cavity via a brain abscess and a bone defect in the skull base. Radical mastoidectomy was performed to remove the cholesteatoma. The roof of the mastoid cavity was covered extensively with fascia and a pedicled temporalis muscle flap. One week post-operatively, computed tomography and magnetic resonance imaging showed no pneumocephalus.Conclusion:Pneumocephalus arising from a cholesteatoma-induced brain abscess and extending into the lateral ventricles is an important entity, with an atypical appearance on computed tomography and magnetic resonance imaging.
Ordinary Farmers Living Anarchist Time: Arishima Cooperative Farm in Hokkaido, 1922–1935
Authors: KONISHI SHO 
Published: December 2012

AbstractThis paper offers a fresh anarchist history of modern rural experience at the heart of Japan's modernization project in Hokkaido. The rationalization of agricultural methods and the establishment of big farms in Hokkaido worked by tenant farmers served the dual purpose of both colonizing and modernizing Japan's northern frontier. Against the idea of progress imbued in that colonial project, the anarchist and celebrity writer, Arishima Takeo, liberated his tenant farmers by dissolving his tenant farm in Niseko in 1922. The farmers were made the new cooperative owners. Members of the farm, made famous during widespread tenant-farmer disputes, believed they stood at the heart of progress. ‘Sōgo fujō’ (mutual aid) was viewed as an ethic for social transformation, democracy and elimination of hierarchy that linked the farmers with the wider world. It was the farmers’ consciousness of working in a new era, better than ever before, that made them modern. Their community offers us a case study of the imagination and experience of modern temporality amongst the most unlikely subjects of the modern, ordinary agricultural laborers in rural Asia in the early twentieth century. This anarchist history challenges the conceptual framework that has categorized rural Japan as the seat of conservative politics, nativism and traditionalism, and the antithesis of modernity.