bluuebunny/crossref_metadata_2025_split huggingface dataset:
The influence of various welding wires on microstructure, and mechanical characteristics of AA7075 Al-alloy welded by TIG process
Authors: Fouad Ramy A. , Habba Mohamed I. A. , Elshaghoul Yousef G. Y. , El-Sayed Seleman Mohamed M. , Hafez Khalid M. , Hamid F. S. , Barakat Waheed S. 
Published: August 2024

AbstractOwing to their exceptional mechanical properties, the various welding wires used to combine aluminum can meet the needs of many engineering applications that call for components with both good mechanical and lightweight capabilities. This study aims to produce high-quality welds made of AA7075 aluminum alloy using the GTAW technique and various welding wires, such as ER5356, ER4043, and ER4047. The microstructure, macrohardness, and other mechanical characteristics, such as tensile strength and impact toughness, were analyzed experimentally. To check the fracture surface of the AA7075 welded joints, the specimens were examined using optical and scanning electron microscopy (SEM). A close examination of the samples that were welded with ER5356 welding wire revealed a fine grain in the weld zone (WZ). In addition, the WZ of the ER4043 and ER4047 welded samples had a coarse grain structure. Because the hardness values of the welded samples were lower in the WZ than in the base metal (BM) and heat-affected zone (HAZ), the joints filled with ER5356 welding wire provided the highest hardness values compared to other filler metals. Additionally, the ER4047 filler metal yielded the lowest hardness in the weld zone. The welding wire of ER5356 produced the greatest results for ultimate tensile stress, yield stress, welding efficiency, and strain-hardening capacity (Hc), whereas the filler metal of ER4043 produced the highest percentage of elongation. In addition, the ER4047 fracture surface morphology revealed coarser and deeper dimples than the ER5356 fine dimples in the welded joints. Finally, the highest impact toughness was obtained at joints filled with the ER4047 filler metal, whereas the lowest impact toughness was obtained at the BM.
The role of microglia in neuronal and cognitive function during high altitude acclimatization
Authors: Hatch Kathleen , Lischka Fritz , Wang Mengfan , Xu Xiufen , Stimpson Cheryl D. , Barvir Tara , Cramer Nathan P. , Perl Daniel P. , Yu Guoqiang , Browne Caroline A. , Dickstein Dara L. , Galdzicki Zygmunt 
Published: August 2024

AbstractDue to their interactions with the neurovasculature, microglia are implicated in maladaptive responses to hypobaric hypoxia at high altitude (HA). To explore these interactions at HA, pharmacological depletion of microglia with the colony-stimulating factor-1 receptor inhibitor, PLX5622, was employed in male C57BL/6J mice maintained at HA or sea level (SL) for 3-weeks, followed by assessment of ex-vivo hippocampal long-term potentiation (LTP), fear memory recall and microglial dynamics/physiology. Our findings revealed that microglia depletion decreased LTP and reduced glucose levels by 25% at SL but did not affect fear memory recall. At HA, the absence of microglia did not significantly alter HA associated deficits in fear memory or HA mediated decreases in peripheral glucose levels. In regard to microglial dynamics in the cortex, HA enhanced microglial surveillance activity, ablation of microglia resulted in increased chemotactic responses and decreased microglia tip proliferation during ball formation. In contrast, vessel ablation increased cortical microglia tip path tortuosity. In the hippocampus, changes in microglial dynamics were only observed in response to vessel ablation following HA. As the hippocampus is critical for learning and memory, poor hippocampal microglial context-dependent adaptation may be responsible for some of the enduring neurological deficits associated with HA.
Impact of war on stroke incidence in Ivano-Frankivsk, Ukraine
Authors: Shkoruta Dominika Paula , Senkiv Vasylyna , Vovchuk Volodymyr , Popadynets Oksana , Kotyk Taras 
Published: August 2024

AbstractStroke is an extensive health problem in Ukraine, the prominence and effects of which are aggravated by the burden of the ongoing Russo-Ukrainian War. In this study, we aimed to holistically examine the overall stroke epidemiology in Ivano-Frankivsk using data from a secondary healthcare center in the city. We determine an increasing trend in stroke admissions since 2020, with a notable 22.4% increase in 2023, mainly due to ischemic stroke occurrence. In the same year, a significant non-linear relationship between stroke incidence and frequency of news about attacks was observed. Ordinal regression analysis of general sociodemographic, clinical, and healthcare-related factors influencing outcomes for intravenous thrombolysis-treated patients, revealed the significance of the 24-h National Institutes of Health Stroke Scale score (0.32 ± 0.03) and interaction of age and Door-to-Needle Time (− 0.28 ± 0.08). However, the extension of the latter independently is not significantly correlated with patient outcomes. In conclusion, war-induced stress, intranational migrations, and lack of adequate chronic cardiovascular disease management are primarily responsible for these results. Modulations and improvements to the current healthcare system, including managing chronic diseases and early stroke symptom recognition, are necessary to optimize patient outcomes.
Cell-free expression with a quartz crystal microbalance enables rapid, dynamic, and label-free characterization of membrane-interacting proteins
Authors: Khakimzhan Aset , Izri Ziane , Thompson Seth , Dmytrenko Oleg , Fischer Patrick , Beisel Chase , Noireaux Vincent 
Published: August 2024

AbstractIntegral and interacting membrane proteins (IIMPs) constitute a vast family of biomolecules that perform essential functions in all forms of life. However, characterizing their interactions with lipid bilayers remains limited due to challenges in purifying and reconstituting IIMPs in vitro or labeling IIMPs without disrupting their function in vivo. Here, we report cell-free transcription-translation in a quartz crystal microbalance with dissipation (TXTL-QCMD) to dynamically characterize interactions between diverse IIMPs and membranes without protein purification or labeling. As part of TXTL-QCMD, IIMPs are synthesized using cell-free transcription-translation (TXTL), and their interactions with supported lipid bilayers are measured using a quartz crystal microbalance with dissipation (QCMD). TXTL-QCMD reconstitutes known IIMP-membrane dependencies, including specific association with prokaryotic or eukaryotic membranes, and the multiple-IIMP dynamical pattern-forming association of the E. coli division-coordinating proteins MinCDE. Applying TXTL-QCMD to the recently discovered Zorya anti-phage system that is unamenable to labeling, we discovered that ZorA and ZorB integrate within the lipids found at the poles of bacteria while ZorE diffuses freely on the non-pole membrane. These efforts establish the potential of TXTL-QCMD to broadly characterize the large diversity of IIMPs.
Weight gain leads to greater adverse metabolic responses in South Asian compared with white European men: the GlasVEGAS study
Authors: McLaren James , Gao Xuan , Ghouri Nazim , Freeman Dilys J. , Richardson Janice , Sattar Naveed , Gill Jason M. R. 
Published: August 2024

AbstractSouth Asians (SAs) develop type 2 diabetes at lower body mass index values than white Europeans (WEs). This basic human experimental study aimed to compare the metabolic consequences of weight gain in SA and WE men without overweight or obesity. Fourteen SAs and 21 WEs had assessments of body composition, metabolic responses to mixed-meal ingestion, cardiorespiratory fitness and physical activity, and a subcutaneous abdominal adipose tissue biopsy, before and after 4–6 weeks of overfeeding to induce 5–7% weight gain. Here we show that body mass index and whole-body adipose tissue volume increases similarly between ethnic groups, but SAs gain less lean tissue. SAs experience a substantially greater decrease in insulin sensitivity compared with WEs (38% versus 7% decrease, P = 0.009), have fewer small (37.1% versus 60.0%, P = 0.003) and more large (26.2% versus 9.1%, P = 0.005) adipocytes at baseline and have a smaller decrease in very small adipocytes with weight gain (−0.1% versus −1.9%, P < 0.0001). Ethnic differences in adipocyte morphology are associated with SA’s greater adverse metabolic changes with weight gain. ClinicalTrials.gov registration: NCT02399423.
EPDR1 promotes PD-L1 expression and tumor immune evasion by inhibiting TRIM21-dependent ubiquitylation of IkappaB kinase-β
Authors: Qian Xiaoyu , Cai Jin , Zhang Yi , Shen Shengqi , Wang Mingjie , Liu Shengzhi , Meng Xiang , Zhang Junjiao , Ye Zijian , Qiu Shiqiao , Zhong Xiuying , Gao Ping 
Published: August 2024

AbstractWhile immune checkpoint blockade (ICB) has shown promise for clinical cancer therapy, its efficacy has only been observed in a limited subset of patients and the underlying mechanisms regulating innate and acquired resistance to ICB of tumor cells remain poorly understood. Here, we identified ependymin-related protein 1 (EPDR1) as an important tumor-intrinsic regulator of PD-L1 expression and tumor immune evasion. Aberrant expression of EPDR1 in hepatocellular carcinoma is associated with immunosuppression. Mechanistically, EPDR1 binds to E3 ligase TRIM21 and disrupts its interaction with IkappaB kinase-b, suppressing its ubiquitylation and autophagosomal degradation and enhancing NF-κB-mediated transcriptional activation of PD-L1. Further, we validated through a mouse liver cancer model that EPDR1 mediates exhaustion of CD8+ T cells and promotes tumor progression. In addition, we observed a positive correlation between EPDR1 and PD-L1 expression in both human and mouse liver cancer samples. Collectively, our study reveals a previously unappreciated role of EPDR1 in orchestrating tumor immune evasion and cancer progression.
Exercise-Based Dysphagia Treatment: A Proposed Checklist
Authors: Yee Joanne , Smaoui Sana , Rogus-Pulia Nicole ,   on behalf of the FRONTIERS Collaborative
Published: August 2024

Purpose:
Oropharyngeal swallowing exercise-based interventions are frequently utilized to target physiologic mechanisms with the goal of improving swallowing function. However, study replicability and evidence synthesis regarding effects of interventions are limited due to inconsistent reporting on factors known to influence treatment delivery. In order to promote consistency of reporting factors associated with replicability, the authors constructed a set of preferred parameters focused on dysphagia as part of the initial version of the larger tool (Framework for RigOr aNd Transparency In REseaRch on Swallowing or FRONTIERS).

Method:
Thirty-eight initial questions were assembled by the authors as part of the treatment subsection. Questions were then reviewed by individuals in the FRONTIERS collaborative who have expertise in research, clinical practice, or both.

Result:
Twenty-four questions were removed following review, reducing the final set of treatment-focused questions to 14 questions.

Conclusions:
The revised set of questions provides users of the exercise-based treatment section of the FRONTIERS checklist with an initial checklist to promote transparency and rigor to improve study replicability and evidence synthesis. We intend for this treatment section of FRONTIERS to undergo further refinement following commentary and feedback.
Participant Characteristics for Dysphagia Research: A Proposed Checklist
Authors: Werden Abrams Sophia , Kurosu Atsuko , Namasivayam-Macdonald Ashwini ,   on behalf of the FRONTIERS Collaborative
Published: August 2024

Purpose:
Participant characteristics are underreported; however, they impact swallowing impairments and subsequent access to assessment and intervention. Standards for rigorous and transparent reporting of dysphagia research are required. The Framework for RigOr aNd Transparency In REseaRch on Swallowing (FRONTIERS) offers a critical appraisal tool for dysphagia research. This article outlines questions for participant characteristics in dysphagia research as part of the larger FRONTIERS tool.

Method:
An exploratory literature review was conducted to determine how participant characteristics, eligibility criteria, and definitions of health and dysphagia are reported in the literature. Findings were cross-referenced with other relevant critical appraisal tools. A list of questions was generated and refined iteratively with the entire FRONTIERS collaborative until consensus was met.

Results:
The participant characteristics portion of the FRONTIERS tool includes eight questions and 16 possible subquestions. Examples for how the tool might be used, as well as rationales for inclusion of all questions, are included.

Conclusions:
Including detailed characteristics of research participants may support understanding of how best to serve marginalized and underrepresented populations more effectively. Critical appraisal tools, such as FRONTIERS, may help to improve the rigor and transparency in dysphagia research, ultimately improving patient care.
A Proposed Framework for Rigor and Transparency in Dysphagia Research: Prologue
Authors: Rogus-Pulia Nicole , Affoo Rebecca , Namasivayam-MacDonald Ashwini , Noad Brandon , Steele Catriona M. ,   on behalf of FRONTIERS Collaborative
Published: August 2024

Purpose:
Scientific transparency and rigor are essential for the successful translation of knowledge in clinical research. However, the field of oropharyngeal dysphagia research lacks guidelines for methodological design and reporting, hindering accurate interpretation and replication. This article introduces the Framework for RigOr aNd Transparency In REseaRch on Swallowing (FRONTIERS), a new critical appraisal tool intended to support optimal study design and results reporting. The purpose of introducing FRONTIERS at this early phase is to invite pilot use of the tool and open commentary.

Methods:
FRONTIERS was developed by collaborating researchers and trainees from six international dysphagia research labs. Eight domains were identified, related to study design, swallowing assessment methods, and oropharyngeal dysphagia intervention reporting. Small groups generated questions capturing rigor and transparency for each domain, based on examples from the literature. An iterative consensus process informed the refinement and organization of primary and subquestions, culminating in the current initial version of FRONTIERS.

Results:
FRONTIERS is a novel tool, intended for use by oropharyngeal dysphagia researchers and research consumers across disciplines. A web application enables provisional use of the tool, and an accompanying survey solicits feedback regarding the framework.

Conclusion:
FRONTIERS seeks to foster rigor and transparency in the design and reporting of oropharyngeal dysphagia research. We encourage provisional use and invite user feedback. A future expert consensus review is planned to incorporate feedback. By promoting scientific rigor and transparency, we hope that FRONTIERS will support evidence-based practice and contribute to improved health outcomes for individuals with oropharyngeal dysphagia.
Experiences of Acquired Brain Injury as Expressed Through Mask-Making: A Qualitative Analysis
Authors: Gregory Sarah Kaytlyn , Kemp Amy M. 
Published: August 2024

Purpose:
Acquired brain injury (ABI) extends beyond the immediate aftermath, and understanding individual experience of ABI is paramount to providing effective support mechanisms. This study examined how people with ABI used mask-making to engage in self-expression.

Method:
Publicly available data from the Unmasking Brain Injury Project website, an advocacy group for people with ABI, were analyzed. A qualitative approach with hybrid inductive/deductive analysis was used to explore how people with ABI use art to express their emotional experiences of ABI.

Results:

In total, 1,049 masks had narratives describing the visual components and meaning in the associated masks. Three major themes emerged: the multiplicity of experiences after ABI, including positive, negative, and mixed outcomes; the expression of emotional pain and living with loss through art; and the importance of positivity, purpose, and faith in the experience with ABI.
Multiplicity
was the central expression represented in the masks. The most commonly represented emotional experiences were:
emotional pain and living with loss
and
positivity, purpose,
and
faith
. The masks incorporated literal depictions of the ABI, visual metaphors, and intentional use of colors and shapes for self-expression.

Conclusions:
These results support previous findings that emotional experiences after ABI are complex and often interlaced with several emotions. The most prominent feelings include emotional pain and living with loss, and positivity, purpose, and faith. Mask-making may be a particularly appropriate method for people with ABI to process or express emotional experiences, as well as to provide clinicians with visual records of sense of self, coping, or progress.
Patient-Reported Outcome Measures for Swallowing: A Proposed Checklist
Authors: Shapira-Galitz Yael , Anderson Amber , Balou Matina ,   on behalf of the FRONTIERS Collaborative
Published: August 2024

Purpose:
Patient-reported outcome measures (PROMs) are an important tool both in clinical practice and research involving patients with swallowing disorders. There are several challenges to be overcome and methodological details to be adequately reported to ensure rigor and transparency in studies utilizing PROMs in dysphagia research. For this reason, the Framework for RigOr aNd Transparency In REseaRch on Swallowing (FRONTIERS), a critical appraisal tool developed to ensure rigor and transparency in dysphagia research, has devoted a domain to PROMs. The aim of this current article, as part of a larger forum of articles, is to present the PROM section of FRONTIERS and describe its development.

Method:
A literature review was carried out on PROMs in the field of dysphagia by three members of the FRONTIERS collaborative to identify items that were necessary for the rigorous application and transparent reporting of PROMs utilized in research of swallowing disorders in human subjects. Framework items were then subjected to an iterative process of feedback and consensus among the three members of the working group as well as all members of the FRONTIERS collaborative. Items were flagged for review and revised as needed until consensus was achieved on the final list. The final item list was compared to existing critical appraisal tools for PROMs.

Results:
The final checklist for the PROMs domain included 20 “Yes/No” questions that can be broadly divided into three categories: (a) development and validation, (b) patient population, and (c) PROM administration method. Each item is presented with a rationale for its inclusion.

Conclusions:
The use of the FRONTIERS Framework will serve researchers and those appraising quality of research involving PROMs. More broadly, the FRONTIERS Framework will facilitate improved rigor and transparency across dysphagia research. Special considerations and future goals are discussed.
Dimmable constant weight polar‐coded non‐orthogonal multiple access with orthogonal space‐time block coding visible light communication systems
Authors: Babalola Oluwaseyi Paul , Balyan Vipin 
Published: August 2024

AbstractThis study investigates the integration of dimmable constant weight polar‐coded non‐orthogonal multiple access (NOMA) with orthogonal space‐time block coding (OSTBC) in visible light communication (VLC) systems over Nakagami‐ fading environments. The proposed scheme aims to enhance the reliability of VLC systems by reducing the outage probability while accommodating dimming requirements. By allowing multiple users to utilize the same time‐frequency resources and adjust power levels based on individual channel conditions, the system optimizes resource utilization. Additionally, the OSTBC method provides effective communication among multiple users by leveraging transmit diversity to improve system performance. The efficacy of the proposed approach is demonstrated through analytical analysis and Monte Carlo simulations, showcasing superior outage probability performance compared to conventional Alamouti‐STBC schemes.
Improve conservation voltage regulation effects by integrating more distributed renewable generations
Authors: Li Ang , Zhong Jin 
Published: August 2024

AbstractDue to intermittent renewable energy and fluctuating load demand, distribution networks with renewable distributed generation (DG) installations are more likely to suffer voltage issues and significant power losses. The performance of conservation voltage regulation (CVR) schemes may be adversely affected by the undesirable voltage profile at specific nodes. This paper aims to reduce power losses in CVR‐implemented networks by optimally planning new renewable DGs without changing the existing ones. A scenario‐based optimal renewable DG planning model is proposed with a novel scenario formation method. The uncertainties of load demand and renewables are captured jointly and formed into a finite number of scenarios based on a multivariate Gaussian mixture model (MultiGMM). The locations and capacities of different types of new renewable DGs are optimally planned for CVR performance improvements on power loss saving by aggregating the operation status and probabilities of the scenarios using mixed‐integer non‐linear programming (MINLP). A time‐series simulation is formulated for accuracy verification. The results of case studies show that the proposed model can significantly reduce power losses, active load demand, and reactive load demand. The accuracy of the planning results can be guaranteed with fewer scenarios compared to a widely used classical scenario‐based planning method.
Analysis of hybrid AC/DC transmission system: A Turkey case study
Authors: Karaca Eda , Nuroğlu Fatih Mehmet 
Published: August 2024

AbstractThe need to transmit energy in the most effective way arises in parallel with the demand for energy in developing countries. As the amount of transmitted power increases, transmission lines can become overloaded, causing a blackout. This study aims to increase the transmission capacity without experiencing right‐of‐way problems by converting Turkey's existing high voltage AC systems to hybrid AC/DC systems. With such a design, it is aimed at providing more efficient and continuous transmission by using the high‐voltage DC system's low‐loss feature at long distances. Using the 400 kV double circuit line structure, the existing electricity transmission system is modelled using real data in the DigSILENT PowerFactory. The electromagnetic fields that will occur due to the use of AC and DC circuits on the same tower in such a transformation situation are analysed with FEMM 4.2, based on the finite element method. The compliance of the electromagnetic fields that will occur with the use of hybrid 400 kV AC and 500 kV DC was determined in the study. In addition, according to the simulation results, it is predicted that in the case of hybrid AC/DC transmission, the current transmission capacity would increase and the losses would decrease.