bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality by Design Optimization of Telmisartan-loaded Self-nanoemulsifying Drug Delivery Systems
Authors: Maharana Rajib Lochan , Swain Suryakanta , Mahapatra Santosh Kumar , Jena Bikash Ranjan 
Published: August 2024

Aim:
This study aimed to develop a QbD-based SNEDDS for Telmisartan to enhance its biopharmaceutical performance.

Background:
Quality by Design (QbD) was incorporated by selecting the Critical Process Pa-rameters (CPPs) as influential variables upon the desired responses. Using Design of Experiments (DoE) software, oil, and S/CoS were tested for pre-isotropic compatibility and formulation im-provement. A heating-cooling cycle and phase separation were used to determine the formula-tions' dispersibility, self-emulsifying time, mean globule size, and stability.

Objective:
Using Design of Experiments (DoE) software, oil (Capmul MCM C-10) and surfactant (Labrasol)/co-surfactant (Tween-20, and PEG-600) (S/CoS) ratios were optimized for pre-isotropic compatibility and formulation improvement.

Methods:
Aerosil-200, Sylysia-350, 550, and 730 were used as porous carriers, and Neusilin US2 as an adsorbing agent resulted in free-flowing granules of self-nano emulsifying drug delivery systems. The SNEDDS was further formulated into tablets using a direct compression technique with enhanced disintegration properties.

Results:
The prepared SNEDDS tablets exhibited a 71% increase in drug dissolution as compared to the pure drug and marketed formulation after the in vitro dissolution studies.

Conclusion:
This QbD approach offers a promising strategy for developing SNEDDS formula-tions for poorly soluble drugs like Telmisartan.
Design and Evaluation of Tools for the Psychological Prevention of Injuries in Baseball Pitchers
Authors: Garit Jesús Ríos , Surita Yanet Pérez , Cases Silvia Solé , Romero César Montoya , Reyes Rodríguez Amanda Beatriz , Cárdenas María del Carmen Chávez 
Published: August 2024

Aims:
To determine, through the evaluation of experts, the introduction in the professional practice of tools designed for the psychological prevention of injuries in high-performance baseball pitchers in a Cuban province.

Background:
The psychological interventions for primary injury prevention contribute to the transition from the biomedical to the biopsychosocial approach in sports injury care. However, the studies carried out are very scarce, few generalizable and insufficient to facilitate the multidisciplinary work around the psychological preparation of the athlete as a method of prevention.

Objective:
The objective of this study is to evaluate by experts the design of an Android application and procedure to guide the psychological prevention of injuries in high-performance baseball pitchers.

Methods:
A methodological investigation was carried out to design the tools, which were evaluated by 11 experts who had a professional experience between 14 and 41 years (M=26.64; SD=11.74). Using the preference method, an ad-hoc questionnaire was applied to obtain the evaluations, being processed by empirical distribution of frequencies, descriptive statistics, Kendall´s coefficient of concordance and coefficient of variation.

Results:
The theoretical-methodological foundations of the procedure design, the definition of users, stages and functions, the coherence between tasks, techniques, instruments and means, structure and functionality, and the Android application, were highly valued.

Conclusion:
The designed tools have a high level of adequacy, are pertinent and sufficient to contribute to the psychological prevention of injuries, so they can be introduced into the professional practice of sports psychologists, coaches, and baseball pitchers from Villa Clara. However, its application must be accompanied by a process of experimental research to determine its efficacy, effectiveness, and efficiency.
Evaluating the Implementation of Integrated Proactive Supportive Care Pathways in Oncology: Master Protocol for a Cohort Study
Authors: Franzoi Maria Alice , Pages Arnaud , Papageorgiou Loula , Di Meglio Antonio , Laparra Ariane , Martin Elise , Barbier Aude , Renvoise Nathalie , Arvis Johanna , Scotte Florian , Vaz-Luis Ines 
Published: August 2024

Background
Supportive care (SC) refers to the prevention and management of complications of cancer and its treatment. While it has long been recognized as an important cancer care delivery component, a high proportion of patients face unaddressed SC needs, calling for innovative approaches to deliver SC.

Objective
The objective of this master protocol is to evaluate the implementation of different integrated proactive SC pathways across the cancer care continuum in our institution (Gustave Roussy, Villejuif, France). Pathways studied in this master protocol may occur shortly after diagnosis to prevent treatment-related burden; during treatment to monitor the onset of toxicities and provide timely symptom management; and after treatment to improve rehabilitation, self-management skills, and social reintegration.

Methods
This study is guided by the Reach, Effectiveness, Adoption, Implementation, and Maintenance framework. The primary objective is to evaluate the impact of SC pathways on patients’ distress and unmet needs after 12 weeks, measured by the National Comprehensive Cancer Network’s Distress Thermometer and Problem List. Secondary objectives will focus on the pathways (macrolevel) and each SC intervention (microlevel), evaluating their reach (administrative data review of the absolute number and proportion of clinical and sociodemographic characteristics of patients included in the pathways); short-term and long-term efficacy through their impact on quality of life (EQ-5D-5L and the 30-item European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire) and symptom burden (MD Anderson Symptom Inventory, Hospital Anxiety and Depression Scale, Insomnia Severity Index, and 22-item European Organization for Research and Treatment of Cancer Sexual Health Questionnaire); adoption by patients and providers (administrative data review of SC referrals and attendance or use of SC strategies); barriers to and leverage for implementation (surveys and focus groups with patients, providers, and the hospital organization); and maintenance (cost-consequence analysis). Pilot evaluations with a minimum of 70 patients per pathway will be performed to generate mean Distress Thermometer scores and SDs informing the calculation of formal sample size needed for efficacy evaluation (cohorts will be enriched accordingly).

Results
The study was approved by the ethics committee, and as of February 2024, a total of 12 patients were enrolled.

Conclusions
This study will contribute toward innovative models of SC delivery and will inform the implementation of integrated SC pathways of care.

Trial Registration
ClinicalTrials.gov NCT06479057; https://clinicaltrials.gov/study/NCT06479057

International Registered Report Identifier (IRRID)
PRR1-10.2196/52841
Association Between Fatty Liver Index and Incidence of Cataract Surgery in Individuals Aged 50 Years and Older Based on the Korean National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) Data: Longitudinal Retrospective Cohort Study
Authors: Kim Yonghwan , Kim Jeongsook , Seo Eoi Jong , Kim Kyung Tae , Lee Jae-woo , Kim Joungyoun , Kang Hee-Taik 
Published: August 2024

Abstract

Background
Cataract is a leading cause of vision impairment. Obesity-related risk factors, including insulin resistance, increase the risk of cataract. The fatty liver index (FLI) is a biomarker for noninvasive fat layer prediction of nonalcoholic fatty liver disease. The FLI has been used to evaluate the metabolic contribution in other organs besides the eye. However, no study exists on the FLI and eye disease.

Objective
This retrospective cohort study for the association between the FLI and incidence of cataract surgery in individuals older than 50 years was designed to show that a higher FLI is associated with an increased incidence of cataract surgery in individuals aged 50 years and older.

Methods
This study was retrospectively designed based on the Korean National Health Insurance Service-Health Screening Cohort (NHIS-HEALS) cohort (median follow-up of 9.8 years). Participants were assigned to 1 of 3 groups based on the FLI: low (FLI<30), intermediate (FLI 30-59), or high (FLI≥60). Kaplan-Meier survival analysis was performed on the cumulative incidence of all-cataract and senile-cataract surgery. Multivariable Cox proportional hazards regression models were used to study the association between the FLI group and cataract surgery after adjusting for potential confounders.

Results
Of the 138,347 included participants, the incidence of cataract surgery was 12.49% (4779/38,274), 13.95% (6680/47,875), and 14.16% (7496/52,930) in the low, intermediate, and high FLI groups, respectively. After adjusting for all confounding factors, hazard ratios (HRs; 95% CIs) in the high FLI group for all-cataract surgery were 1.111 (1.028‐1.199) and 1.184 (1.101‐1.274) in men and women, respectively, when compared with the low FLI group. HRs (95% CIs) in the high FLI group for senile-cataract surgery were 1.106 (1.022‐1.197) and 1.147 (1.065‐1.237) in men and women, respectively, when compared with the low FLI group. The project was conducted between August 2023 and February 2024 without donations from external bodies.

Conclusions
Individuals with a higher FLI had a higher risk of all-cataract surgery. This association was maintained even after limiting the analyses to senile-cataract surgery.
Digital Economy Development, Agricultural Technology Innovation and Agricultural Economy Resilience
Authors: HONG Jin-luan , ZHOU Jun-jie 
Published: August 2024

Based on the provincial data of 2013-2022, this paper discusses the mechanism of agricultural economy resilience affected by the development of digital economy. The results are obtained by using fixed effect, intermediary effect and threshold effect as follows: (1) the development of digital economy can improve the resilience of agricultural economy, and the conclusion passes the robustness test. (2) Mechanism test shows that agricultural technology innovation indirectly acts between the digital economy and the resilience of the agricultural economy. (3) Through the threshold model, it is found that the non-linear characteristics of agricultural technology innovation appear. Therefore, in order to improve the resilience of agricultural economy, the paper puts forward suggestions on strengthening regional infrastructure construction and enhancing the support for agricultural technology innovation.
Direito à arte é direito de conhecer arte, produzindo arte
Authors: Coutinho Andréa Senra , Oliveira Bruna Tostes 
Published: August 2024

Esse texto traz uma discussão, algumas vezes silenciada ou esquecida, sobre a relevância da formação artística e cultural para todo e qualquer brasileiro/a, e desta como direito proclamado obrigatório nas principais leis de educação desse país. São percebidos ainda alguma negligência e certo desinteresse em dar um acesso ampliado do conhecimento artístico às crianças e jovens nos ambientes escolares, cabendo à sociedade civil a cobrança do cumprimento das leis. Sobretudo pela compreensão da importante contribuição que as artes (visuais, sonoras e cênicas) podem dar na constituição do sujeito crítico na atualidade. Portanto, enquanto direito, o que falta para o ensino de arte estar assegurado? Além de trazer essa provocação, são apresentadas argumentações acerca do que se espera do ensino de arte contemporâneo, endossado por um relato de experiência exitosa em uma escola pública. São também apontadas a indispensável formação inicial e continuada de professores/as, bem como indicações de organização, planejamento e fontes de pesquisa que auxiliem num melhor entendimento das especificidades desse campo de conhecimento na educação básica, com base em autores como Ana Mae Barbosa, Luciana Loponte e outros.
Etnoenfermería y teoría del cuidado cultural, evidencias metodológicas en la investigación en enfermería: una revisión integrativa
Authors: Briñez Ariza Karol Johanna , Ortiz Whitaker María Carolina , González Soto Cinthia Elizabeth 
Published: August 2024

Introducción: La atención en salud involucra aspectos culturales que deben conocerse para beneficiar a las personas desde el cuidado de enfermería. Objetivo: Describir el uso de la etnoenfermería como diseño de investigación y la teoría del cuidado cultural de Madeleine Leininger en la literatura de enfermería. Metodología: Se realizó una revisión integrativa bajo las fases de Withmoore y Knalf. La búsqueda bibliográfica se llevó a cabo en Medline, Cuiden Plus, Lilacs, Scopus y ScienceDirect, con los descriptores “investigación cualitativa”, “enfermería”, “asistencia sanitaria culturalmente competente” y “enfermería transcultural” en idioma inglés, español, portugués, incluyendo artículos originales publicados entre 2013 a 2023. Resultados: Se eligieron 12 artículos que fueron codificados para el surgimiento de cuatro categorías: necesidad de formación en etnoenfermería y teoría del cuidado de la cultura; reconocimiento del contexto cultural y barreras para el cuidado culturalmente congruente; diversidad y universalidad de los cuidados culturales; y acciones para el cuidado culturalmente congruente. Conclusiones: La revisión permitió reconocer que la teoría de cuidado cultural y la etnoenfermería han sido escasamente utilizadas en la práctica científica y profesional de enfermería. Es necesario incentivar en los profesionales la importancia de valorar el respeto por las diferentes culturas en los servicios de salud.
Prevalencia y caracterización de nefropatía de etiología no determinada en hospital de segundo nivel, Honduras
Authors: Fajardo Leitzelar Fernando Arturo , Ramírez-Osorto Luis José , Pérez Arias Cecilia Mariel , Benítez López Ada Alejandra , Ordóñez Banegas Gloria María , Gómez-Flores Edric Orlando , Merino Andrés 
Published: August 2024

Introducción: la enfermedad renal crónica de etiología no determinada (ERCnd) es una enfermedad tubulointersticial aguda que progresa a enfermedad renal crónica (ERC), particularmente presente en Mesoamérica. Honduras cuenta con una alta tasa de mortalidad por ERCnd; sin embargo, carece de estudios suficientes para determinar datos clínicos y prevalencia.
Objetivo: establecer la prevalencia, caracterización clínica y epidemiológica de la ERCnd en pacientes con diagnóstico de ERC de marzo del año 2022 a febrero del 2023.
Metodología: se realizó un estudio observacional, transversal y descriptivo en una muestra de 89 expedientes de pacientes con diagnóstico de ERC. Con previa autorización, se aplicó un instrumento de 32 preguntas.
Resultados: la prevalencia fue del 53,93?%, de los cuales: 87,50?% eran masculinos, 52,00?% tenían entre 30 y 49 años, 85,42?% eran de zona rural, el 100?% eran mestizos, el 35,42?% solteros y el 60,42?% agricultores, la afluencia más frecuente se registró en febrero del 2023. Los espasmos y la debilidad muscular estuvieron presentes en el 62,50?% y el 54,20?% de los pacientes, respectivamente.
Discusión: la prevalencia fue mayor a la reportada en años anteriores por la Secretaría de Salud de Honduras y en comparación con estadísticas de la región. Algunos factores de riesgo incluyeron: hombres, adultos jóvenes provenientes de zonas rurales, agricultores y consumo de antiinflamatorios no esteroideos (Aines). Las manifestaciones más frecuentes fueron: palidez, espasmos y debilidad muscular, en concordancia con los principales motivos de ingreso hospitalario. Las tasas de filtración glomerular (TFG) promedio obligaban a instaurar terapia sustitutiva renal (hemodiálisis) y los datos ultrasonográficos e histopatológicos fueron escasos o ausentes, dadas las limitaciones económicas de los estudiados; estas deficiencias deben ampliarse para futuras investigaciones.
Tricarboxylic Cycle Intermediates in Combination with Calcium Phosphate Chelators and Sodium Bicarbonate Increases eGFR in Patients with Stages 3b, 4 and 5 CKD: A Retrospective Observational Study
Authors: Hernández Miramontes Jorge Antonio , Méndez Durán Antonio , Hernández Villanueva Jorge Alberto 
Published: August 2024

Introduction: Currently, the conservative management of chronic kidney disease (CKD) involves treating the primary disease and its consequences, as well as improving altered biochemical markers. Evidence suggests that the key management strategy for slowing down the progression of the disease is nephroprotection.
Objective: This study aimed to evaluate the effect of the supply of TCA cycle intermediates in combination with calcium carbonate, calcium lactate, and sodium bicarbonate in patients with CKD.
Methodology: A retrospective observational study was undertaken in nephrology and internal medicine clinics in Mexico. The study enrolled patients aged over 18 with stages 3b, 4, and 5 chronic kidney disease (CKD) who were not undergoing renal replacement therapy (RRT) and had received treatment based on TCA therapy.
Results: The study included a total of 55 patients with CKD. The results showed an increase in eGFR from a baseline average of 16.73 ± 1,374 mL/min to a final average of 19.18 ± 1,516 mL/min and a decrease in creatinine values from a baseline average of 4.26 ± 2.44 mg/dL to a final average of 3.77 ± 2.23 mg/dL. These changes had a statistical significance P?0.05.Conclusions: The observed benefits of TCA in combination with sodium bicarbonate, calcium carbonate, and calcium lactate include: 1) Increased eGFR, 2) Decreased serum creatinine, 3) Decreased serum urea, 4) Decreased serum phosphorus, 5) Increased serum hemoglobin, and 6) Maintenance of albumin levels within normal ranges. Adjuvant therapy with the combination of TCA could be a useful tool as a new therapeutic option in patients with CKD.
Makna Belis dalam Perkawinan Matrilineal Masyarakat Ngada (Ditinjau Berdasarkan Kitab Hukum Kanonik No. 1062)
Authors: Kowe Agustinus , Endi Yohanes , Suherli Silvius , Pao Saferinus 
Published: August 2024

Belis adalah sebuah tradisi adat yang masih dipegang teguh oleh masyarakat Flores NTT. Belis merupakan mas kawin yang diberikan oleh pihak pria kepada pihak wanita dalam pernikahan adat. Tujuan dari penelitian ini ialah menilai makna Belis dalam perkawinan adat Ngada. Masyarakat Ngada memegang teguh bahwa perkawinan sebagai model persekutuan pribadi antara laki-laki dan perempuan. Perkawinan matrilineal merupakan bagian penting bagi masyarakat Ngada dalam kekerabatan, yang mana perempuan diutamakan sebagai ahli waris dan penerus tahta dalam keluarga. Hampir seluruh masyarakat Ngada, menganut sistem perkawinan matrilineal. Perkawinan sistem matrilineal ini tidak terletak pada kaum perempuan saja, tetapi mempunyai relasi yang erat dengan persekutuan atau lembaga tertentu. Sistem matrilineal di tengah masyarakat Ngada dijalankan berdasarkan kemampuan dan berbagai penilaian, keluarga, dan masyarakat secara luas terutama oleh kaum perempuan. Sistem perkawinan tersebut diajarkan secara turun-temurun, disepakati, dan dipatuhi. Bagi Gereja Katolik perkawinan merupakan sebuah sakramen yakni tanda dan sarana yang pada dasarnya menyelamatkan. Masalah yang muncul adalah orang tidak dapat membayar Belis apabila hal itu diminta dengan harga atau nilai yang tinggi. Tujuan agar menyajikan kepada pembaca bahwa Belis ini dapat dibayar sesuai dengan kemampuan. Metode yang digunakan adalah kepustakaan. Hasil dari makna Belis ini menyatakan sesungguhnya bahwa Belis itu dapat dilakukan sesuai dengan kesepakatan bersama. Tulisan ini menemukan arti dan makna Belis dalam terang kitab hukum kanonik (KHK) 1062.
Kearifan Budaya Sambas: Kehamilan, Kelahiran dan Kematian
Authors: Barella Yusawinur , Aminuyati Aminuyati , Nurhesti Nurhesti , Zuvita Alya Istiqla , Lisa Rosita , Maharani Maharani , Fera Fera 
Published: August 2024

Kelahiran dan Kematian berfokus pada kearifan lokal yang ada di daerah Sambas. Kearifan lokal merupakan sudut pandang kehidupan di dalam masyarakat yang diwariskan dan diturunkan secara turun temurun oleh leluhur dan suatu ilmu pengetahuan yang memiliki strategi kehidupan yang berwujud aktivitas yang dilakukan oleh masyarakat lokal untuk menjawab permasalahan dalam pemenuhan kebutuhan mereka. Tujuan dari penelitian ini untuk memperkenalkan budaya kelahiran dan kematian melayu Sambas. Metode yang digunakan adalah metode kualitatif. Terdapat dua cara dalam memperoleh data yaitu data primer diperoleh melalui wawancara serta data sekunder diperoleh melalui jurnal. Hasil dari penelitian ini menjelaskan bahwa terdapat beberapa ritual serta pantangan yang harus dilakukan dalam proses kelahiran maupun kematian pada budaya melayu Sambas. Ritual ini berupa ritual kehamilan dan kemataian pada suku melayu sambas, pada ritual kehamilan terdapat beberapa proses yaitu: tuang minyak, bepapas. Kelahiran terdapat beberapa proses yaitu: Belinggang, Turun tanah, dan tepung tawar, serta kematian yaitu:kajikan, mengkafani, ngelayat, memandikan mayat, menyolatkan mayat, melewati kolong mayat, turun tanah, dan miare.
Menggali Konsep Filosofis Ritual Wu’u Lolo Masyarakat Lamaole-Lawomaku-Flores Timur dalam Perspektif “Being in the Other” menurut Heidegger
Authors: Heribertus Ama Bugis  , Riyanto Armada 
Published: August 2024

Fokus penelitian ini ialah mengkaji dan memahami konsep "being in the other" (berada dalam yang lain) Martin Heidegger dalam ritual Wu'u Lolo yang dilakukan oleh masyarakat Lamaholot di Indonesia Timur. Martin Heidegger merupakan seorang filsuf terkenal dalam tradisi fenomenologi dan eksistensialisme mengembangkan pandangan filosofis yang menekankan pentingnya interaksi sosial dan konteks dalam membentuk pemahaman individu tentang eksistensi dan realitas. Dalam Ritual Wu'u Lolo, masyarakat Lamaholot terlibat dalam serangkaian upacara adat yang melibatkan interaksi sosial, pertukaran budaya, dan pemahaman kolektif tentang dunia spiritual mereka. Penelitian ini menggunakan kerangka konseptual Heidegger untuk menganalisis bagaimana peserta ritual "berada dalam yang lain" saat berpartisipasi dalam upacara ini, bagaimana pengalaman tersebut membentuk pemahaman mereka tentang eksistensi, dan bagaimana konsep ini berperan dalam mempertahankan dan memperkaya tradisi budaya masyarakat Lamaholot. Metodologi yang digunakan dalam penelitian ini ialah studi kepustakaan. Melalui analisis ini, penelitian ini bertujuan untuk membawa pemahaman filosofis Heidegger tentang "being in the other" ke dalam konteks budaya yang berbeda, menunjukkan relevansi dan aplikabilitas konsep tersebut dalam pemahaman eksistensi manusia di berbagai latar belakang budaya. Penelitian ini menemukan bahwa konsep Being in Other ditemukan melalui partisipasi masyarakat Lamalohot dalam ritual Wulu Lolo membuat mereka terhubung dengan orang lain, alam dan juga sang Pencipta.