bluuebunny/crossref_metadata_2025_split huggingface dataset:
Procyanidin B2 attenuates neurological deficits and blood–brain barrier disruption in a rat model of cerebral ischemia
Authors: Wu Shuangchan , Yue Yuan , Li Jian , Li Zhike , Li Xiaofei , Niu Yunhui , Xiang Jin , Ding Hong 
Published: July 2015

ScopeDisruption of the blood–brain barrier (BBB) is a major pathogenic mechanism of neurological dysfunction and death after ischemic stroke. The aim of our study was to investigate the effect of procyanidin B2 (PB), a bioactive food compound, on BBB disruption induced by ischemic stroke and explore the underlying mechanism.Methods and resultsPB was administrated intragastrically once a day starting at 3 h after transient middle cerebral artery occlusion (MCAO). PB treatment significantly decreased the infarction volume, brain edema, and neurological deficits after MCAO. PB prevented BBB disruption against ischemic stroke, as indicated by the reduction of Evans blue leakage and IgG levels. These results were also corroborated by immunofluorescence staining and Western blot analysis of ZO‐1. Additionally, levels of reactive oxygen species and malondialdehyde were lessened in the ipsilateral ischemic area of brain by PB. The activities of antioxidant enzymes were elevated. Meanwhile, PB reversed the suppression of NF‐E2‐related factor nuclear translocation, and increased the protein expression of HO‐1, GSTα, and NQO1 in the ipsilateral ischemic area of brain.ConclusionPB attenuates neurological deficits and BBB disruption in a rat model of cerebral ischemia, and the neuroprotection of PB is associated with activation of NF‐E2‐related factor pathway.
Design of a compact triband monopole antenna for WLAN and WiMAX applications
Authors: Tang Zhaoyang , Liu Keyu , Yin Yingzeng , Lian Ruina 
Published: July 2015

ABSTRACTA compact triband CPW‐fed monopole antenna for wireless local area network (WLAN) and worldwide interoperability for microwave access (WiMAX) applications is proposed in this letter. The antenna consists of a rectangular ring, a pair of F‐shaped stubs, and a rectangular monopole radiator. By optimizing the designed parameters of these structures, three separate resonant modes are generated to cover the desired bands. A prototype of the proposed antenna with a compact size of 23 × 36 mm2 is fabricated and tested. Measured results show that the antenna has the impedance bandwidths of 240 MHz (2.35–2.59 GHz), 620 MHz (3.31–3.93 GHz), and 1280 MHz (5.07–6.35 GHz) with reflection coefficient less than −10 dB, which can cover both WLAN in the 2.4/5.2/5.8 GHz bands and WiMAX in the 3.5/5.5 GHz. In addition, good radiation patterns are also achieved in both E‐ and H‐planes. Based on the measured results, the proposed antenna is a good candidate for WLAN and WiMAX applications. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:2298–2303, 2015
Dual‐band planar mimo antenna for WLAN application
Authors: Liu Yi , Yang Lin , Liu Ying , Ren Jian , Wang Jianxiao , Li Xi 
Published: July 2015

ABSTRACTA dual‐band multiple‐input‐multiple‐output (MIMO) antenna covering 2.2–2.7GHz and 4.9–5.9 GHz frequency bands for wireless local area network (WLAN) application is presented. The proposed antenna consists of two C‐shaped monopole antenna elements and a decoupling structure. The decoupling structure based on a new printed bent T‐shaped resonator which is embedded between the antenna elements to obtain high isolation in WLAN bands. The proposed MIMO antenna has a compact size of 40 × 40 mm2 (0.32 λ0 × 0.32 λ0) and the antenna prototype is fabricated and measured. The measured results with the decoupling structure show that the mutual coupling between two ports is less than −15 dB and the reflection coefficients are less than −10 dB over the operating bands. The good impedance matching and high isolation make the antenna a good candidate as a terminal antenna for WLAN applications. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:2257–2262, 2015
Planar triple‐band antenna for LTE/GSM/UMTS and WLAN/WiMAX mobile device applications
Authors: Huang Hui‐Fen , Zhao Wei 
Published: July 2015

ABSTRACTA planar triple‐band antenna with size 40 × 18 × 0.8 mm3 for LTE/GSM/UMTS and WLAN/WiMAX is developed in this article. The antenna is constructed in four steps. The first step is named Ant1. In one side of the substrate, a nonfolded strip is connected with a ground plane and a rectangle patch at both end of the nonfolded strip, respectively. Ant1 is fed by a T‐strip, which is in the other side of the substrate. Ant1 generates two modes at 2.8 and 1.97 GHz and is responsible for the operation band 1.25–3.65 GHz. The second step is named Ant2. On the basis of Ant1, the nonfolded strip is changed into folded strip. Two new resonant modes at 680 MHz and 5.8 GHz are introduced. Ant2 is responsible for the operation band (660–1120 MH) and (1.71–3.85 GHz). The third step is named Ant3. On the basis of Ant2, two branches (Br‐1, Br‐2) are introduced. Br‐1 and Br‐2 are in the same side of Ant1 and connected with the ground plane. Then the operation band (5.15–6.17 GHz) is added on the basis of Ant3. The fourth step is named Ant4. A slot is etched from the rectangular patch, and the impedance is greatly improved in the three operation bands. As a result, a triple‐band antenna covering the LTE 700/2300/2500 (1710 −2690 MHz)/GSM 850/900/(690–960 MHz)/GSM 1800/1900/UMTS (1710–2170 MHz)/WiMAX 3.5 GHz (3400–3650 MHz)/5.4 GHz (5250–5850 MHz) is formed. The gain for the proposed antenna is 1.2–4.2 dBi, and the radiation efficiency is about 67–95%. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:2277–2281, 2015
Low‐profile open‐slot antenna with three branch slots for triple‐wideband LTE operation in the metal‐framed smartphone
Authors: Wong Kin‐Lu , Li Ya‐Jyun 
Published: July 2015

ABSTRACTA low‐profile open‐slot antenna capable of providing a triple‐wideband LTE operation for the metal‐framed smartphone is presented. The antenna has a low profile of 7 mm and can fit in a narrow region between the metal frame and the display panel of the metal‐framed smartphone. The antenna comprises three branch slots sharing a same opening disposed at the top or bottom edge of the casing of the smartphone. Two branch slots are excited using a U‐shape microstrip feedline with wideband matching circuits embedded therein while the third‐branch slot is excited parasitically. With the proposed feeding arrangement, the antenna provides the triple‐wideband LTE operation to cover the low band of 698–960 MHz, middle band of 1710–2690 MHz, and high band of 3400–3800 MHz. Details of the proposed open‐slot antenna are presented and discussed. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:2231–2238, 2015
Innovative bit channel in downstream passive optical network frames based on reusing of bit sequences
Authors: Lafata Pavel 
Published: July 2015

ABSTRACTIn this article, a novel idea of a hidden bit channel established in the downstream passive optical network (PON) frames is proposed. As the downstream frames in time‐division multiplexed, PONs are broadcasted and delivered to all active end‐point optical network units (ONUs), and this bitstream could be potentially used for creating an additional hidden bit channel containing bits for all ONUs. Therefore, the downstream frames could simply transmit standard information fields and ONU contributions according to the standard PON principles; however, these bits could be also reused multiple times to carry additional data for each ONU in a form of segmented bit sequences spread within the entire bitstream. To establish effective bit channel with positive bit gain, an effective algorithm for addressing its bits is necessary. The most promising bit addressing algorithm is proposed within this article together with the results obtained by its simulations and performance evaluations. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:2346–2351, 2015
A novel CPW‐fed antenna with dual band‐notched charectrestics for UWB applications
Authors: Sefidi Mehdi , Zehforoosh Yashar , Moradi Shahram 
Published: July 2015

ABSTRACTIn this article, a coplanar waveguide fed (CPW‐fed) ultrawideband (UWB) antenna with dual band‐notched characteristics is presented. Using two diamond‐shaped stepped impedance resonators, two notched bands are obtained. The simulation and measurement results show that proposed antenna covers the frequency band between 2.85 and 11 GHz (118
), defined by VSWR < 2. The proposed antenna has a total size 20 × 20 × 1.6 mm3 and performed at the whole UWB with dual notched bands at WiMAX (3.4–3.6 GHz) and WLAN (5.15–5.85 GHz). The proposed antenna has a desirable VSWR level; radiation pattern characteristics for UWB frequency band rang. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:2391–2394, 2015
Pulsed microwave exposure real time and dynamically reduces reactive oxygen species in rat pheochromocytoma cells in vivo
Authors: Wang Changzhen , Zhou Hongmei , Wang Lifeng , Wang Shuiming , Xu Xinping , Chen Peng , Wu Ke , Peng Ruiyun , Hu Xiangjun 
Published: July 2015

ABSTRACTWith the widespread and ever‐increasing application of microwave technology in our daily lives, the potential adverse effects on biological systems from exposure to microwaves are extremely interesting based on thermal and nonthermal effects, especially nonthermal effects on the nervous system. To real time and dynamically elucidate the diversity of reactive oxygen species (ROS) in rat pheochromocytoma (PC12) cells using a real‐time‐pulsed microwave device combining laser confocal microscopy (LSCM). A LSCM system was designed, and its physical properties, including irradiation cavity simulation, field intensity distribution, and average specific absorption rate (SAR), were analyzed and a stable field intensity distribution as well as a precise average SAR were observed. Subsequently, the diversity of ROS in PC12 cells under pulsed microwave exposure was determined by LSCM online. Additionally, the total ROS in PC12 cells was determined by flow cytometry after pulsed microwave exposure. The ROS signal in single PC12 cell was rapidly quenched as the irradiation time was extended, whereas the total ROS showed no changes in flow cytometry after microwave exposure. This indicates that the change of intracellular ROS in PC12 cells by microwave exposure is a real‐time and dynamic process, and provides a significant reference for studying the biological effects of microwaves. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:2395–2400, 2015
Two‐port circular polarized antenna array for point‐to‐point communication
Authors: Nayan Mohd K. A. , Jamlos Mohd F. , Lago Herwansyah , Jamlos Mohd A. 
Published: July 2015

ABSTRACTA two‐port circular polarization (CP) array antenna is presented in this article. The proposed antenna used two‐port which each port is designed with 2 × 2 array structure and both array consist of four circular radiating elements. The used of 90° triple‐coupled phased shift polarizer at both left and right side of circular‐slotted patches with two‐port generate CP aptitude with high gain performance. Moreover, the presence of slots at center of circular elements produce discontinuity effect to assist change in the E‐field and H‐Field rotation of RF current and force the current to flow in CP. Axial ratio of 1.95 dB confirms the CP capability. Nonetheless, the proposed antenna demonstrates a good characteristic for MIMO's isolation with mutual coupling of −55.0 dB (S12) and −45.1 dB (S21), correlation coefficient of 1.2015e‐4 and diversity gain (Gapp) of 9.9999. The proposed antenna also produced gain as high as 13.23 dB for both port. With those capabilities, the antenna designed is suitable for 5.8 GHz point‐to‐point communication. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:2328–2332, 2015
Mucoepidermoid Carcinoma in Children: A Single Institutional Experience
Authors: Techavichit Piti , Hicks M. John , López‐Terrada Dolores H. , Quintanilla Norma M. , Guillerman R. Paul , Sarabia Stephen F. , Sayeed Hadi , Nuchtern Jed G. , Paulino Arnold C. , Muscal Jodi A. , Okcu M. Fatih , Chintagumpala Murali 
Published: July 2015

Purpose and objectiveTo determine the clinicopathologic and molecular features and outcome of children with mucoepidermoid carcinoma (MEC).MethodsA retrospective analysis of clinical and histopathologic findings was performed in patients with MEC diagnosed at Texas Children's Cancer Center between 2000 and 2014.ResultsTen female and four male patients with median age 12 years (range 7–19 years) were included in the study. Tumors involved major salivary glands, minor salivary glands of the palate, and the tracheobronchial tree. Nine of 11 patients with salivary MEC underwent more than one surgical resection at the time of initial diagnosis to achieve a gross total resection. Three patients with tracheobronchial tumors underwent pulmonary lobectomy. Three patients received postoperative radiation therapy. No patient was treated with chemotherapy. Histopathologic grades were classified as low (n = 2), intermediate (n = 9), and high (n = 3). All 12 patients with tumor tissue available for testing were positive for MECT1/MAML2 fusion transcripts. There were no deaths, metastases, or recurrences in this series, with a median follow‐up of 24 months (range 5–96 months).ConclusionsLow to intermediate histopathologic grade MECs are more common than high grade MEC in children. In contrast to adults, MECT1/MAML2 fusion transcripts occur with a frequency of 100% in our pediatric MEC series. Complete excision is the treatment of choice and is associated with excellent outcome. The role of radiotherapy is unclear, but may be indicated in patients with high grade tumors with positive surgical margins. Pediatr Blood Cancer 2015; 9999:1–5 © 2015 Wiley Periodicals, Inc.
Seasonal variation of triterpenes and phenolic compounds in australian Centella asiatica (L.) Urb
Authors: Alqahtani Ali , Tongkao‐on Wannit , Li Kong M. , Razmovski‐Naumovski Valentina , Chan Kelvin , Li George Q. 
Published: July 2015

AbstractIntroductionSpecific triterpenes, phenolic acids and flavonoids in Centella asiatica have been found to be bioactive. Harvesting the plant when these putative bioactive compounds are at their highest concentrations would provide consistency in their chemical profile, thus ensuring the quality and efficacy of derived medicinal products.ObjectiveThe aim of the study was to determine the impact of harvesting time on the contents of major triterpenoid and phenolic compounds in C. asiatica.MethodologyAustralian C. asiatica was collected from a designated area in different months. The principal triterpenes (asiaticoside, madecassoside, asiatic acid and madecassic acid), flavonoid compounds (rutin, quercetin and kaempferol) and chlorogenic acid were quantitatively determined by HPLC‐DAD analysis.ResultsTriterpenoid, kaempferol and chlorogenic acid content showed significant variation (p < 0.05) in different collecting months. The total content of the four triterpenes reached its highest levels in January and February (83.15 ± 0.16 mg/g and 78.41 ± 0.16 mg/g, respectively), the summer season of the southern hemisphere, and their lowest values in winter (June) and spring (October) seasons (35.65 ± 0.20 and 35.50 ± 0.55 mg/g, respectively). Similarly, the contents of chlorogenic acid and kaempferol were the highest in December and January (1.62 ± 0.01 and 0.33 ± 0.01 mg/g, respectively), and the lowest in June (0.06 ± 0.01 and 0.09 ± 0.01 mg/g, respectively).ConclusionThe results indicate that harvesting C. asiatica in summer returns the highest yield of the target triterpenoids, kaempferol and chlorogenic acid. Copyright © 2015 John Wiley & Sons, Ltd.
Fetal aortic valve stenosis: a critique of case selection criteria for fetal intervention
Authors: Hunter Lindsey E. , Chubb Henry , Miller Owen , Sharland Gurleen , Simpson John M. 
Published: July 2015

AbstractObjectiveSelection of fetuses with aortic stenosis (AS) for prenatal intervention has been influenced by published scoring systems. This study aimed to test these scoring systems by retrospective application to consecutive cases of fetal AS.MethodsRetrospective analysis of the echocardiographic findings of 31 consecutive fetuses with AS evaluated at a tertiary fetal cardiology centre. Published ‘eHLHS’ scores and threshold scores were applied to the group and compared to postnatal management, in terms of biventricular repair versus single ventricle palliation.ResultsThirty‐one fetuses were identified with AS, and eHLHS was identified in 17 at the initial echocardiogram. No fetus with a full eHLHS score (3/3 or 4/4) achieved a biventricular repair. Three fetuses had a favourable threshold score (≥4), one of whom had a successful biventricular outcome. Seven fetuses had an unfavourable threshold score (<4) and underwent a univentricular pathway.ConclusionThe eHLHS score is a reliable predictor for the progression to HLHS at term. The score identifies those who would achieve a biventricular repair postnatally without prenatal intervention. A minority of fetuses with favourable threshold scores may achieve a biventricular repair postnatally without prenatal intervention, but eHLHS and an unfavourable threshold score (<4) predict a single ventricle pathway postnatally. © 2015 John Wiley & Sons, Ltd.
Managing factitious disorder and type 1 diabetes
Authors: Deshpande Sarika , Jenaway Alison , Simmons David 
Published: July 2015

AbstractFactitious disorder is a condition in which a patient feigns the symptoms of an illness in order to assume the sick role and get care. Less common is the context in which a patient has a genuine illness, but adopts non‐compliance or other behaviours likely to worsen the illness. This is more difficult to identify and to treat.We present two cases of patients with type 1 diabetes mellitus, affected by factitious disorder. We describe the impact of the disorder on their glucose control and general health, the challenges faced in diagnosing the psychiatric condition, and how the resulting situations were managed in a secondary care setting. We highlight the strategies often employed by patients in factitious disorder, and suggest counter‐strategies that can be implemented to minimise risk to patients. Ultimately, timely therapy for the factitious disorder could aid glucose control, and the overall health of the patient. Copyright © 2015 John Wiley & Sons.
PEGDA‐based luminescent polymers prepared by frontal polymerization
Authors: Illescas Javier , Ramírez‐Fuentes Yessica S. , Zaragoza‐Galán Gerardo , Porcu Pasquale , Mariani Alberto , Rivera Ernesto 
Published: July 2015

ABSTRACTFrontal polymerization (FP) of poly(ethylene glycol) diacrylate (PEGDA) was carried out using benzoyl peroxide (BPO) as radical initiator. In addition, a pyrene containing monomer, 1‐pyrenebutyl acrylate (PyBuAc), was incorporated as a fluorescent probe in order to obtain luminescent materials with different chromophore contents. The resulting polymers were characterized by FT‐IR spectroscopy in the solid state and their thermal properties were determined by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Moreover, the optical properties of these materials were studied by absorption and fluorescence spectroscopy. The maximum amount of the incorporated pyrene‐containing monomer into the polymer matrix was limited to 1 wt % by the polymerization process. The obtained labeled polymers poly(PEGDA‐co‐PyBuAc) exhibited a broad absorption band at 345 nm. The fluorescence spectra of these polymers exhibited mainly “monomer emission” so that no excimer emission was observed. It is possible to tune the color of the emitted light by varying the pyrene content in the samples. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 2890–2897
Morbidity after elective resection of prenatally diagnosed asymptomatic congenital pulmonary airway malformations
Authors: Hall Nigel J. , Chiu Priscilla P.L. , Langer Jacob C. 
Published: July 2015

SummaryBackground/AimThe optimal management of prenatally diagnosed asymptomatic congenital pulmonary airway malformations (CPAM) is controversial. Since there is a paucity of data relating to surgical risks in this specific population, we reviewed our experience to further inform this controversy.MethodsEthically approved 10 year (2004–2013) retrospective review. Patients were included only if the CPAM was diagnosed prenatally and remained asymptomatic. Indication for surgery was physician recommendation and/or parental choice.Main resultsSixty patients were identified. Median age at surgery was 6.5 months (range 65 days to 9.6 years). Resections were performed thoracoscopically (n = 51, one conversion) or by thoracotomy (n = 9). Surgical time was 2.5 hr (43 min to 4.75 hr). A chest drain was used in 58/60 and remained in situ 53 hr (23–108). There were no intra‐operative complications or blood transfusions. All patients were extubated at the end of the procedure with no re‐intubations. Post‐operative hospitalization was 73.4 hr (23.8 hr to 4.2 days). Overall, complications occurred in 14/60 (23%). Eleven were minor but three were major: tension pneumothorax associated with new presentation of a small previously undiagnosed diaphragmatic hernia 5 days following resection; aggressive fibromatosis of the chest wall in the region close to resection 2 years later; and near‐fatal hypovolemic cardiac arrest due to massive haemorrhage from a feeding vessel on postoperative day 7. There were no deaths and no cases of pleuropulmonary blastoma.ConclusionResection of prenatally diagnosed asymptomatic CPAM is associated with a significant risk of complications, which may be life threatening. These data contribute to a balanced discussion of risks and benefits for these children. Pediatr Pulmonol. 2016;51:525–530. © 2015 Wiley Periodicals, Inc.
Development of a Targeted Urine Proteome Assay for kidney diseases
Authors: Cantley Lloyd G. , Colangelo Christopher M. , Stone Kathryn L. , Chung Lisa , Belcher Justin , Abbott Thomas , Cantley Jennifer L. , Williams Kenneth R. , Parikh Chirag R. 
Published: July 2015

PurposeSince human urine is the most readily available biofluid whose proteome changes in response to disease, it is a logical sample for identifying protein biomarkers for kidney diseases.Experimental designPotential biomarkers were identified by using a multiproteomics workflow to compare urine proteomes of kidney transplant patients with immediate and delayed graft function. Differentially expressed proteins were identified, and corresponding stable isotope labeled internal peptide standards were synthesized for scheduled MRM.ResultsThe Targeted Urine Proteome Assay (TUPA) was then developed by identifying those peptides for which there were at least two transitions for which interference in a urine matrix across 156 MRM runs was <30%. This resulted in an assay that monitors 224 peptides from 167 quantifiable proteins.Conclusions and clinical relevanceTUPA opens the way for using a robust mass spectrometric technology, MRM, for quantifying and validating biomarkers from among 167 urinary proteins. This approach, while developed using differentially expressed urinary proteins from patients with delayed versus immediate graft function after kidney transplant, can be expanded to include differentially expressed urinary proteins in multiple kidney diseases. Thus, TUPA could provide a single assay to help diagnose, prognose, and manage many kidney diseases.