bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organisational learning through a charitable trust-initiated project focusing on end-of-life care
Authors: Leung Tiffany Cheng Han , Snell Robin Stanley , Lee Daisy 
Published: August 2024

PurposeWe identify lessons from a project sponsored by a large charitable trust, which sought to build capability for end-of-life (EOL) care in Hong Kong through interdisciplinary and multi-agency collaboration.Design/methodology/approachAn in-depth case study drawing on 21 in-depth interviews with diverse stakeholders was conducted. Lyman et al.’s (2018) model of organisational learning (OL) in healthcare settings was applied to analyse the relative emphasis on particular contextual factors and mechanisms, and to identify outcomes perceived to have been achieved.FindingsInfrastructure such as materials for assessment and education received the most emphasis among the contextual factors and deliberate learning such as training sessions received the greatest attention among the mechanisms. While perceptions indicated that desired outcomes were being achieved in terms of social impact, there were relatively few mentions of “soft” factors such as enhanced motivation, leadership or OL skills among staff.Originality/valueThis study extends the literature on how to create valuable social impact through OL. While prior studies have examined social impact in terms of solutions for social and environmental problems, ours is one of the few that examines how improvements are made to organisations’ capability to deliver such impacts in the context of healthcare.
Innovation strategies and financial performance: a resource dependence perspective for Fintech management decision-making
Authors: Wang Jian-Hang , Dai Xiaoyong , Wu Yu-Hsien , Chen Hsiang Lin 
Published: August 2024

Purpose The study examines how process/organizational innovation and R&D spending mediate the relationship between financial performance and the resource dependence theory in Fintech, providing insights into effective innovation strategies for achieving sustainable financial performance.Design/methodology/approach Data from 191 financial firms in Taiwan was collected from annual reports using the Taiwan Economic Journal (TEJ), a financial information provider. Content analysis was used to measure innovation activities and financial performance, with process and organizational innovation defined. R&D expenditures were also collected and used in statistical analysis to explore the relationship between variables.Findings This study on the financial services industry shows that process innovation and R&D expenditure positively impact firm performance, while organizational innovation may have a negative short-term effect but could have long-term benefits.Research limitations/implications Limitations of this study include vulnerability to spurious effects and the use of data from only listed financial service firms. Future research should use more short-term performance data and include unlisted firms in the financial services industry to extend the study’s coverage.Originality/value This study extends resource dependence theory to financial services and explores the effects of process and organizational innovation on firm performance. Results show that internal process management boosts performance, while external collaboration with startups enhances Fintech innovation and efficiency, with positive short-term effects. The study highlights the importance of interacting with external organizations to access resources and improve performance in financial services.
From words to action (research): a new generation of workplace training
Authors: Harikkala-Laihinen Riikka , Fäldt Sanna , Bäckman Erik 
Published: August 2024

Purpose
This paper aims to explore how a new type of workplace training program can be created that truly enables participants to move from words to action. Recognizing the need to understand trainee–work environment dynamics the authors criticize training efforts that center on targeted learning events, instead highlighting the role of preparation and following up. In doing so, the authors tackle the lack of guidance practitioners experience when designing and implementing workplace training programs.

Design/methodology/approach
The authors present action research on a pilot workplace training program focused on wellbeing in an academic work setting. The data collection draws from the case study tradition. The authors collect data through interviews (21), field notes of participant observation (3 occasions), participant-produced written materials and a feedback survey.

Findings
The authors find that restorative practices, workplace mediation and reteaming enhance the participants’ perceptions of self-efficacy and agency. Throughout the training program, facilitators observe the dynamics of the situation and take part in discussions to encourage exploration and reflection. Thus, facilitators likely need a coaching mindset.

Originality/value
The theoretical contribution stems from an in-depth exploration of trainee–work environment dynamics and novel insights brought to workplace training from adjacent fields of research. The authors introduce a framework for planning participatory workplace training and organizational development programs, which answers a call from practitioners.
Ethical leadership and public healthcare organizational and employee outcomes: the role of psychological meaningfulness
Authors: Barbar Julia , Abualigah Ahmad , Dahleez Khalid , Abou-Al-Ross Sami , Aboramadan Mohammed 
Published: August 2024

Purpose
Based on the theories of social learning, social exchange and social identity, this study aims to examine the impact of ethical leadership on organizational attractiveness and diversity-valuing behavior as well as the mediating role of psychological meaningfulness in the public healthcare sector.

Design/methodology/approach
Data in this study was collected from 545 nurses working in Palestinian hospitals. Structural equation modeling was used to analyze the data.

Findings
The results show positive effect of ethical leadership on organizational attractiveness and diversity-valuing behavior. The findings likewise support the mediating role of psychological meaningfulness on the focal relationships.

Originality/value
This study follows a more comprehensive and a multitheoretical approach and it uses a novel model in an underexamined setting, which is the nursing sector.
When the secondhand economy is not as good as it seems: understanding conflicts and their (ir)resolutions between users on secondhand resale platforms
Authors: Cerio Eva , Debenedetti Alain , Sophie Rieunier 
Published: August 2024

Purpose
Peer-to-peer (P2P) secondhand resale platforms (SRP) are competitive places where different value systems beyond market values interact. This study aims to investigate the conflicts that may arise in interactions between users on SRP and the extent to which these conflicts are (ir)resolved, by drawing on economies of worth theory.

Design/methodology/approach
The study takes a qualitative and interpretative approach to examine 22 active users on P2P resales platforms such as Vinted, including in-depth interviews. Following the Straussian view of grounded theory, the study uses constant comparison (open, axial and selective coding) to analyze data on SRP users’ experiences.

Findings
Drawing on the economies of worth theory, the study shows that SRP users rely on four different value systems or “worlds” when using the platforms (market, domestic, green and civic worlds) that come into conflict, at either an interactional (three conflicts identified) or an individual (two conflicts identified) level. The findings reveal that these conflicts are temporarily resolved at the interactional level and in a sustainable way at the individual level.

Originality/value
This study sheds further light on the relationship between consumers on SRP by offering a more nuanced perspective on these exchanges than market-oriented exchanges. It also analyzes the data through the economies of worth theory, which is an appropriate lens to better understand social interactions and conventions. Finally, the study offers recommendations on how managers can improve buyers’ and sellers’ experiences on these platforms and, thus, foster their satisfaction.
Tapinarof cream for the treatment of plaque psoriasis: Efficacy and safety results from 2 Japanese phase 3 trials
Authors: Igarashi Atsuyuki , Tsuji Gaku , Fukasawa Shuichi , Murata Ryusei , Yamane Satoshi 
Published: August 2024

AbstractTapinarof is a non‐steroidal, topical, aryl hydrocarbon receptor agonist. We evaluated the efficacy and safety of tapinarof cream (1%) in Japanese patients aged ≥18 years with plaque psoriasis in two phase 3 trials, ZBA4‐1 and ZBA4‐2. ZBA4‐1 (N = 158) consisted of a 12‐week, double‐blind, vehicle‐controlled treatment period (period 1) and a 12‐week extension treatment period (period 2). Patients were randomized 2:1 to tapinarof or vehicle in period 1; subsequently, all patients who were enrolled in period 2 received tapinarof. ZBA4‐2 (N = 305) was a 52‐week, open‐label, uncontrolled trial in which all patients received tapinarof. In period 1 of ZBA4‐1, the proportion of patients who achieved a Physician Global Assessment (PGA) score of 0 (clear) or 1 (almost clear) with ≥2‐grade improvement from baseline at week 12 (PGA treatment success, the primary endpoint) was 20.06% in the tapinarof group and 2.50% in the vehicle group (p = 0.0035). The proportion of patients with ≥75% improvement from baseline in the Psoriasis Area and Severity Index (PASI) score at week 12 (PASI75 response, a key secondary endpoint) was 37.7% in the tapinarof group and 3.8% in the vehicle group (p < 0.0001). In ZBA4‐2, PGA treatment success rate was 30.0% at week 12, 51.3% at week 24, and 56.3% at week 52, and PASI75 response rate was 50.4% at week 12, 77.5% at week 24, and 79.9% at week 52, indicating that efficacy responses improved over time and were maintained over 52 weeks. Across the two trials, most adverse events (AEs) were mild or moderate; common AEs included folliculitis and contact dermatitis. In summary, tapinarof cream (1%) was efficacious and generally safe for up to 52 weeks of treatment in Japanese patients with plaque psoriasis.
Do immigrants equally benefit from rent control?
Authors: Bian Xun , Chen Ruoyu , Jiang Hanchen 
Published: August 2024

AbstractThis study examines how immigrants, often concentrated in urban areas with higher rent burdens, benefit from rent control. We focus on New York City's rent stabilization policy, using data from 2002 to 2017. We find that immigrant tenants are more likely to live in rent‐stabilized units than nonimmigrant tenants. However, conditional on living in rent‐stabilized units, immigrants receive $151 less monthly rent discounts than their nonimmigrant counterparts. This notable immigrant–native gap is economically and statistically significant and robust to various checks. Factors like spatial sorting, tenancy duration, policy awareness, and property characteristics primarily contribute to this disparity.
Three‐domain microbial communities in the gut of Pachnoda marginata larvae: A comparative study revealing opposing trends in gut compartments
Authors: Ozbayram Emine Gozde , Kleinsteuber Sabine , Sträuber Heike , Schroeder Bruna Grosch , da Rocha Ulisses Nunes , Corrêa Felipe Borim , Harms Hauke , Nikolausz Marcell 
Published: August 2024

AbstractThis study aimed to examine the bacterial, methanogenic archaeal, and eukaryotic community structure in both the midgut and hindgut of Pachnoda marginata larvae using an amplicon sequencing approach. The goal was to investigate how various diets and the soil affect the composition of these three‐domain microbial communities within the gut of insect larvae. The results indicated a notable variation in the microbial community composition among the gut compartments. The majority of the bacterial community in the hindgut was composed of Ruminococcaceae and Christensenellaceae. Nocardiaceae, Microbacteriaceae, and Lachnospiraceae were detected in midgut samples from larvae feeding on the leaf diet, whereas Sphingomonadaceae, Rhodobacteraceae, and Promicromonasporaceae dominated the bacterial community of midgut of larvae feeding on the straw diet. The diet was a significant factor that influenced the methanogenic archaeal and eukaryotic community patterns. The methanogenic communities in the two gut compartments significantly differed from each other, with the midgut communities being more similar to those in the soil. A higher diversity of methanogens was observed in the midgut samples of both diets compared to the hindgut. Overall, the microbiota of the hindgut was more host‐specific, while the assembly of the midgut was more influenced by the environmental microorganisms.
The patient‐perceived intravaginal ejaculation latency time cut‐off for lifelong premature ejaculation
Authors: Wang Chunlin , Zhong Qianghui , Colonnello Elena , Xi Yu , Sansone Andrea , Zhang Hui , Chen Qingshan , Jannini Emmanuele A. , Zhang Yan 
Published: August 2024

AbstractBackgroundThe current cutoff values of intravaginal ejaculation latency time for diagnosing lifelong premature ejaculation do not always match clinical practice, and the inconsistency in the cutoff values of intravaginal ejaculation latency time among different definitions has also posed challenges to both clinical management and research of premature ejaculation.ObjectivesTo re‐evaluate the intravaginal ejaculation latency time and to find evidence‐based cut‐off values for diagnosing lifelong premature ejaculation that can be widely accepted and match clinical practice.Materials and methodsWe addressed the flaws of previous studies. Lifelong premature ejaculation was diagnosed based on both patient self‐report of premature ejaculation status and scores on the Premature Ejaculation Diagnostic Tool, with a control group consisting of non‐premature ejaculation individuals included for comparison. Utilizing receiver operating characteristic curve analysis, the optimal self‐estimated cutoff value for intravaginal ejaculation latency time in diagnosing lifelong premature ejaculation was determined.ResultsA total of 307 heterosexual participants (mean age = 30.7 ± 6.4) were included, comprising 187 lifelong premature ejaculation patients (mean age = 28.0 ± 4.6) and 120 non‐premature ejaculation individuals (mean age = 35.0 ± 6.5). 2.7% of lifelong premature ejaculation patients experienced anteportal ejaculation. 59.9%, 92%, and 97.9% of lifelong premature ejaculation patients displayed intravaginal ejaculation latency times within 1, 2, and 3 min, respectively. The receiver‐operating characteristic curve's area under the curve was 0.996 with a 95% confidence interval of 0.991–1.000 (p < 0.0001). The perceived intravaginal ejaculation latency time cut‐off at 3.5 (sensitivity = 97.9%, specificity = 99.2%) showed the highest Youden index compared with other options.DiscussionAlthough we found that 92.0% of lifelong premature ejaculation patients had a perceived intravaginal ejaculation latency time within 2 min, a perceived intravaginal ejaculation latency time cutoff value of less than 3.5 min for diagnosing lifelong premature ejaculation could encompass a larger proportion (97.9%) of patients seeking medical help for complaints of PE, and increasing the perceived intravaginal ejaculation latency time cutoff value to 3.5 min would not significantly increase the false‐positive rate.ConclusionThe perceived intravaginal ejaculation latency time cutoff value for diagnosing lifelong premature ejaculation within a clinical practice context is 3.5 min.
A controlled trial of a psychoeducation intervention in reducing depression among parents
Authors: Yakub Nur Asyikin , Mahmud Norashikin , Yusof Junaidah , Ibrahim Farah Adibah , Shari Nurul Izzah , Abdul Rahim Azlan 
Published: August 2024

AbstractGenerally, this study aims to scientifically evaluate the effectiveness of psychoeducation as an intervention for reducing depressive symptoms among parents around Kuala Lumpur. It also examines the relationship between the socio‐demographic factors and the severity of depression among parents as well as the numerous factors associated with depression among the studied population. This study convoluted two phases of intervention which were pre and post, and for the intervention group, a modified version of the family module intervention was given to test the efficacy of the psychoeducation intervention. A total of 61 participants were recruited from four Peoples' Housing Project in Kuala Lumpur. Thirty of them were randomly assigned to the control group and another 31 were assigned to the intervention group. Based on the analysis, there was a mere difference between the mean score of depression and daily hassle due to parenting between both groups during the post‐intervention. Overall findings clearly denote that the family module intervention is an effective intervention in reducing depressive symptoms and parenting daily hassles among the parents in two phases as well as improving mental health literacy among parents.
Would you like to take some more ruxolitinib after your fedratinib?
Authors: Ianotto Jean‐Christophe 
Published: August 2024

In Europe, ruxolitinib and fedratinib are the only JAK2 inhibitors available in local pharmacies. According to trial data, myelofibrosis patients should mostly receive ruxolitinib as first‐line treatment and fedratinib in case of failure or intolerance (depending on their profile). Is it possible to reverse the choice of these drugs?Commentary on: Palandri et al. Ruxolitinib after Fedratinib failure in patients with myelofibrosis: a real‐world case series. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19654.
MVP enhances FGF21‐induced ferroptosis in hepatocellular carcinoma by increasing lipid peroxidation through regulation of NOX4
Authors: Xia Jinkun , Fu Boqi , Wang Zhe , Wen Gaolin , Gu Quanshui , Chen Dayu , Ren Haozhen 
Published: August 2024

AbstractFerroptosis is a novel, iron‐dependent regulatory cell death mainly caused by an imbalance between the production and degradation of intracellular reactive oxygen species (ROS). Recently, ferroptosis induction has been considered a potential therapeutic approach for hepatocellular carcinoma (HCC). Fibroblast growth factor 21 (FGF21) is a new modulator of ferroptosis; however, the regulatory role of FGF21 in HCC ferroptosis has not been investigated. In this study, we explored the role of FGF21 and its underlying molecular mechanism in the ferroptotic death of HCC cells. We identified Major vault protein (MVP) as a target of FGF21 and revealed that knockdown of MVP inhibited the lipid peroxidation levels of HCC cells by decreasing NADPH oxidase 4 (NOX4, a major source of ROS) transcription, thereby attenuating the effect of FGF21‐mediated ferroptosis. On the other hand, MVP overexpression showed the opposite results. Mechanistically, MVP binds to IRF1 and thus interferes with the interaction between IRF1 and the YAP1 promoter, leading to an increase in NOX4 transcription. Importantly, forced expression of IRF1 or downregulation of YAP1 partially reversed the effect of MVP overexpression on HCC ferroptosis. Furthermore, the results in xenograft tumor models suggested that overexpression of MVP can efficiently increase the level of lipid peroxidation in vivo. Taken together, these results provide new insights into the regulatory mechanism of ferroptosis in HCC.
The effects of time‐restricted eating alone or in combination with probiotic supplementation in comparison with a calorie‐restricted diet on endocrine and metabolic profiles in women with polycystic ovary syndrome: A randomized clinical trial
Authors: Talebi Sepide , Shab‐Bidar Sakineh , Moini Ashraf , Mohammadi Hamed , Djafarian Kurosh 
Published: August 2024

AbstractAimTo assess the impact of intermittent fasting, with or without probiotic supplementation, versus a calorie‐restricted diet on anthropometric measures, metabolic status and gonadal variables in women with polycystic ovary syndrome (PCOS).MethodsThis is a randomized, placebo‐controlled, parallel‐arm clinical trial. The effects of the 14:10 early time‐restricted eating (eTRE) strategy alone or combined with probiotics, on obese women with PCOS, were investigated. Participants were divided into three groups: eTRE plus probiotics (n = 30), eTRE plus placebo (n = 30) and a control group following a standard three‐meal‐per‐day diet with daily calorie restriction (DCR) (n = 30). Over 8 weeks, various anthropometric, metabolic, menstrual and gonadal variables were assessed.ResultsA total of 90 individuals were included in the study, with a mean body weight of 81.4 kg, and a mean age of 30 years. Mean (standard deviation) weight loss was not different between the groups at week 8 (TRE + probiotic: −2.2 [1.6] kg vs. TRE + placebo: −2.9 [2.7] kg vs. DCR: −2.5 [1.7] kg). Results revealed that, while all three regimes led to reductions in body weight, body mass index, vascular risk indicators, hirsutism and acne scores, there were no statistically significant differences between the eTRE groups and the control group in terms of weight loss, or improvements in metabolic, menstrual and gonadal variables (P > .05). Additionally, combining probiotics with eTRE did not benefit hormonal and cardiometabolic factors (P > .05).ConclusionsThe eTRE alone or eTRE plus probiotics did not result in significantly greater weight loss or improvements in metabolic, menstrual and gonadal variables compared with the standard three‐meal DCR diet.
Empirical Therapy Versus Tailored Therapy of Helicobacter pylori in Korea: Results of the K‐CREATE Study
Authors: Kim Joon Sung , Kim Byung‐Wook , Kim Jin Il , Chung Woo Chul , Jung Sung Woo , Bang Chang Seok , Kim Gwang Ha , Jeon Seon Woo , Joo Moon Kyoung , Lee Si Hyung , Lim Yun Jeong , Sung Jae Kyu , Seo Seung Young , Park Sun Young , Lee Wan Sik , Lee Hang Lak , Kim Ki Bae , Kim Heung Up 
Published: August 2024

ABSTRACTBackgroundThe optimal duration of regimens for tailored therapy based on genotypic resistance for clarithromycin has yet to be established.AimThis study was a nationwide, multicenter, randomized trial comparing empirical therapy with tailored therapy based on genotypic resistance for first‐line eradication of Helicobacter pylori. We also compared the eradication rates of 7‐ and 14‐day regimens for each group.Patients and MethodsPatients with H. pylori infection were first randomized to receive empirical or tailored therapy. Patients in each group were further randomized into 7‐ or 14‐day regimens. Empirical therapy consisted of a triple therapy (TT) regimen (twice‐daily doses of pantoprazole 40 mg, amoxicillin 1 g, and clarithromycin 500 mg) for 7 or 14 days. Tailored therapy consisted of TT of 7 or 14 days in patients without genotypic resistance. Patients with genotypic resistance were treated with bismuth quadruple therapy (BQT) regimens (twice‐daily doses of pantoprazole 40 mg, three daily doses of metronidazole 500 mg, and four times daily doses of bismuth 300 mg and tetracycline 500 mg) for 7 or 14 days. A 13C‐urea breath test assessed eradication rates. The primary outcome was eradication rates of each group.ResultsA total of 593 patients were included in the study. The eradication rates were 65.7% (201/306) in the empirical therapy group and 81.9% (235/287) in the tailored therapy group for intention‐to‐treat analysis (p < 0.001). In the per‐protocol analysis, the eradication rates of the empirical therapy and tailored groups were 70.3% (201/286) and 85.5% (235/274) (p < 0.001), respectively. There was no difference in compliance between the two groups. The rate of adverse events was higher in the tailored group compared to the empirical group (p < 0.001).DiscussionOur study confirmed that tailored therapy based on genotypic resistance was more effective than empirical therapy for H. pylori eradication in Korea. However, no significant difference was found between 7‐ and 14‐day regimens for each group. Future studies are needed to determine the optimal duration of therapy for empirical and tailored therapy regimens.