bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can the neutrophil-to-lymphocyte ratio be used as an early marker of small fetuses for gestational age? A prospective study
Authors: Salomon David , Fruscalzo Arrigo , Boulvain Michel , Feki Anis , Ben Ali Nordine 
Published: August 2024

BackgroundSmall-for-gestational-age (SGA) fetuses are at increased risk of mortality and morbidity, and less than 30% will be detected by any ultrasound scan within 4 weeks before delivery. Our aim was to evaluate the relationship between neutrophil/lymphocyte ratio (NLR) in the first trimester of pregnancy and SGA fetuses.MethodWe performed a prospective study between June 2021 and August 2022, to evaluate the relationship between the neutrophil to lymphocyte ratio in maternal blood in the first trimester of pregnancy, with the birth of an SGA fetus. One hundred ninety-four participants with singleton pregnancies between 11 + 1 and 13 + 6 weeks of gestation were recruited. Pregnancies affected with diagnosed fetal chromosomal abnormalities, or chronic pathologies were excluded. SGA was defined as birthweight less than the 10th centile (N = 42) and severe SGA as birthweight less than the 3rd centile for gestation (N = 10) according to a locally derived descriptive charts. The NLR value measured in the first trimester was compared between these two groups and controls.ResultsWe found no statistically significant difference in NLR, (3.5 +/−1.2 vs. 3.4+/−1.2, p-value of 0.78) when comparing the SGA less than the 10th centile group to the control group. NLR was also not different between severe SGA and controls (3.6+/−1.4 vs. 3.4+/−1.2 p-value of 0.78).ConclusionWe found no association between first-trimester NLR ratio and SGA.
Impacts of eutrophication on microbial community structure in sediment, seawater, and phyllosphere of seagrass ecosystems
Authors: Deng Wenchao , Chen Shunyang , Chen Shiquan , Xing Bingpeng , Chan Zhuhua , Zhang Yao , Chen Bin , Chen Guangcheng 
Published: August 2024

IntroductionSeagrass-associated microbial communities play a crucial role in the growth and health of seagrasses. However, like seagrass meadows, seagrass-associated microbial communities are often affected by eutrophication. It remains unclear how eutrophication influences the composition and function of microbial communities associated with different parts of seagrass.MethodsWe employed prokaryotic 16S rRNA gene high-throughput sequencing combining microbial community structure analysis and co-occurrence network analysis to investigate variances in microbial community compositions, potential functions and complexities across sediment, seagrass leaves, and seawater within different eutrophic areas of two adjacent seagrass meadows on Hainan Island, China.ResultsOur results indicated that microbial diversity on seagrass leaves was significantly lower than in sediment but significantly higher than in seawater. Both sediment and phyllosphere microbial diversity showed no significant difference between the highly eutrophic and less eutrophic sites in each lagoon. However, sediment microbial diversity was higher in the more eutrophic lagoon, while phyllosphere microbial diversity was higher in the less eutrophic lagoon. Heavy eutrophication increased the relative abundance of phyllosphere microorganisms potentially involved in anaerobic metabolic processes, while reducing those responsible for beneficial functions like denitrification. The main factor affecting microbial diversity was organic carbon in seawater and sediment, with high organic carbon levels leading to decreased microbial diversity. The co-occurrence network analysis revealed that heavy eutrophication notably reduced the complexity and internal connections of the phyllosphere microbial community in comparison to the sediment and seawater microbial communities. Furthermore, ternary analysis demonstrated that heavy eutrophication diminished the external connections of the phyllosphere microbial community with the sediment and seawater microbial communities.ConclusionThe pronounced decrease in biodiversity and complexity of the phyllosphere microbial community under eutrophic conditions can lead to greater microbial functional loss, exacerbating seagrass decline. This study emphasizes the significance of phyllosphere microbial communities compared to sediment microbial communities in the conservation and restoration of seagrass meadows under eutrophic conditions.
Enhancing dementia risk screening with GAN-synthesized periodontal examination and general blood test data
Authors: Oyama Katsunori , Isogai Toshiki , Nakayama Yohei , Kobayashi Ryoki , Kitano Daisuke , Karako Kenji , Sakatani Kaoru 
Published: August 2024

IntroductionThis study aimed to investigate the effectiveness of data augmentation to improve dementia risk prediction using machine learning models. Recent studies have shown that basic blood tests are cost-effective in predicting cognitive function. However, developing models that address various conditions poses challenges due to constraints associated with blood test results and cognitive assessments, including high costs, limited sample sizes, and missing data from tests not performed in certain facilities. Despite being often limited by small sample sizes, periodontal examination data have also emerged as a cost-effective screening tool.MethodsTo address these challenges, this study explored the effectiveness of data augmentation using the Synthetic Minority Over-sampling Technique for Regression with Gaussian noise (SMOGN), a Generative Adversarial Network (GAN), and a Conditional Tabular GAN (CTGAN) on periodontal examination and blood test data. The datasets included parameters such as cognitive assessment results from the Mini-Mental State Examination (MMSE), demographic characteristics, periodontal examination data, and blood test results. Linear regression models, random forests, and deep neural networks were used to evaluate the effectiveness of the synthesized data.ResultsThis study used measured data from 108 participants and the synthesized data generated from the measured data. External validity was evaluated using a different dataset of 41 participants with missing items. The results suggested that normal GANs have the advantage of investigating models in data diversity, whereas CTGANs preserve the data structure and linear relationships in tabular data from the measured data, which drastically improves linear regression models.DiscussionImportantly, by interpolating sparse areas in the distribution, such as age, the synthesized models maintained prediction accuracy for test data with extreme inputs. These findings suggest that GAN-synthesized data can effectively address regression problems and improve dementia risk prediction.
Global, regional, and national burden of stroke attributable to diet high in sodium from 1990 to 2019: a systematic analysis from the global burden of disease study 2019
Authors: Zhang Xuan , Ye Wen-qian , Xin Xue-Ke , Gao Ying-jie , Yang Fan 
Published: August 2024

PurposeGiven the increasing occurrence of stroke and high-sodium diets (DHIS) over the past 30 years, it is crucial to assess the global, national, and regional impact of DHIS on the burden of stroke.Methods and materialsThe Global Burden of Diseases Study 2019 provided the study's data. We used the Bayesian meta-regression tool DisMod-MR 2.1 to evaluate the burden of stroke attributable to DHIS. Age-standardized disability-adjusted life years (ASDR) and age-standardized mortality rate (ASMR) were used to quantify the burden. We perform correlation analysis utilizing the Spearman rank-order correlation method, and we calculate the estimated annual percentage change (EAPC) to evaluate temporal trends.ResultsGlobally, DHIS accounts for 17,673.33 thousand disability-adjusted life years (DALYs) and 700.98 thousand deaths of stroke in 2019. The burden of stroke attributable to DHIS has declined between 1990 and 2019 globally and in the majority of regions, with the largest declines seen in regions with high sociodemographic indexes (SDI). Both ASMR and ASDR were higher regionally in regions with moderate SDI than those in developed regions. Furthermore, the absolute values of EAPC, reflecting the rate of decrease, were notably lower in these regions compared to developed nations. High-income North America, categorized within the SDI regions, notably witnessed the smallest decline in ASDR over the last three decades. Additionally, from 1990 to 2019, males consistently bore a larger burden of stroke attributable to DHIS.ConclusionThe burden of stroke attributable to DHIS remained a major concern despite advancements in public knowledge of stroke and their utilization of emergency medical services. Over the past 30 years, more burden has been placed on males and regions with moderate SDI values; in males, higher EAPC values for both ASMR and ASDR have been found. This underscores the urgent need for effective interventions to alleviate the burden of stroke associated with DHIS.
Altered regional neural activity and functional connectivity in patients with non-communicating hydrocephalus: a resting-state functional magnetic resonance imaging study
Authors: Huang Xiaoyuan , Jin Lu , Chang Tengwu , Liu Jian , Qu Yuan , Li Jinyong , Bai Wenju , Li Chuzhong , Wang Jichao 
Published: August 2024

IntroductionCognitive impairment is a frequent clinical symptom of non-communicating hydrocephalus (NCH) involving multiple domains, including executive function, working memory, visual-spatial function, language, and attention. Functional magnetic resonance imaging (fMRI) can be used to obtain information on functional activity in local brain areas and functional connectivity (FC) across multiple brain regions. However, studies on the associated cognitive impairment are limited; further, the pathophysiological mechanisms of NCH with cognitive impairment remain unclear. Here, we aimed to explore alterations in regional neural activity and FC, as well as the mechanisms of cognitive impairment, in patients with NCH.MethodsOverall, 16 patients with NCH and 25 demographically matched healthy controls (HCs) were assessed using the Mini-Mental State Examination (MMSE) and fMRI. Changes in regional homogeneity (ReHo), degree centrality (DC), and region of interest-based FC were analyzed in both groups. The relationship between fMRI metrics (ReHo, DC, and FC) and MMSE scores in patients with NCH was also investigated.Results and discussionCompared with the HC group, the NCH group exhibited significantly lower ReHo values in the left precentral and postcentral gyri, and significantly higher ReHo values in the left medial prefrontal cortex (MPFC). The NCH group also showed significantly higher DC values in the bilateral MPFC compared with the HC group. Regarding seed-based FC, the MPFC showed reduced FC values in the right superior parietal and postcentral gyrus in the NCH group compared with those in the HC group. Moreover, within the NCH group, MMSE scores were significantly negatively correlated with the ReHo value in the left MPFC and the DC value in the bilateral MPFC, whereas MMSE scores were significantly positively correlated with FC values. To conclude, regional neural activity and FC are altered in patients with NCH and are correlated with cognitive impairment. These results advance our understanding of the pathophysiological mechanisms underlying the association between NCH and cognitive impairment.
Harnessing nature’s pharmacy: investigating natural compounds as novel therapeutics for ulcerative colitis
Authors: Huang You , Wu Qiuhong , Li Sha , Lin Xia , Yang Shasha , Zhu Rui , Fu Chaomei , Zhang Zhen 
Published: August 2024

BackgroundsUlcerative colitis (UC) is a form of chronic inflammatory bowel disease, and UC diagnosis rates continue to rise throughout the globe. The research and development of new drugs for the treatment of UC are urgent, and natural compounds are an important source. However, there is a lack of systematic summarization of natural compounds and their mechanisms for the treatment of UC.MethodsWe reviewed the literature in the databases below from their inception until July 2023: Web of Science, PubMed, China National Knowledge Infrastructure, and Wanfang Data, to obtain information on the relationship between natural compounds and UC.ResultsThe results showed that 279 natural compounds treat UC through four main mechanisms, including regulating gut microbiota and metabolites (Mechanism I), protecting the intestinal mucosal barrier (Mechanism II), regulating intestinal mucosal immune response (Mechanism III), as well as regulating other mechanisms (Mechanism Ⅳ) such as cellular autophagy modulation and ferroptosis inhibition. Of these, Mechanism III is regulated by all natural compounds. The 279 natural compounds, including 62 terpenoids, 57 alkaloids, 52 flavonoids, 26 phenols, 19 phenylpropanoids, 9 steroids, 9 saponins, 8 quinonoids, 6 vitamins, and 31 others, can effectively ameliorate UC. Of these, terpenoids, alkaloids, and flavonoids have the greatest potential for treating UC. It is noteworthy to highlight that a total of 54 natural compounds exhibit their therapeutic effects by modulating Mechanisms I, II, and III.ConclusionThis review serves as a comprehensive resource for the pharmaceutical industry, researchers, and clinicians seeking novel therapeutic approaches to combat UC. Harnessing the therapeutic potential of these natural compounds may significantly contribute to the improvement of the quality of life of patients with UC and promotion of disease-modifying therapies in the future.
Comparative effectiveness and safety of four traditional Chinese medicine injections with invigorating blood circulation, equivalent effect of anticoagulation or antiplatelet in acute myocardial infarction: a Bayesian network meta-analysis
Authors: Chen Jiaping , Shang Juju , Liu Hongxu , Li Xiang , Lai Xiaolei , Lou Yan , Zhou Huiwen 
Published: August 2024

Background: Traditional Chinese medicine injections with invigorating blood circulation (TCMI-IBCs), which have been used as antithrombosis therapies, are widely employed by Chinese clinicians as adjuvant therapy for acute myocardial infarction (AMI).Objective: A Bayesian network meta-analysis was conducted to contrast the effectiveness and safety of four TCMI-IBCs in AMI.Methods: Eight Databases were thoroughly searched before 31 December 2023, for randomized controlled trials (RCTs) focusing on the application of TCMI-IBCs combined with conventional treatments (CT) to treat AMI. All-cause mortality (ACM) was the major endpoint. Secondary outcomes included bleeding events, malignant arrhythmia (MA), recurrent myocardial infarction (RMI), left ventricular ejection fraction (LVEF), and adverse events. Stata17.0 and GeMTC software were employed for Bayesian network meta-analysis.Results: A total of 73 eligible RCTs involving 7,504 patients were enrolled. Puerarin injection (PI), Danhong injection (DI), sodium Tanshinone IIA Sulfonate injection (STSI), and Danshen Chuanxiongqin injection (DCI) combined with CT can significantly reduce the occurrence of ACM and improve LVEF in AMI (P &lt; 0.05), while without significant impact on bleeding events or MA (P &gt; 0.05). STSI + CT would be the optimal treatment strategy in lowering RMI and ACM. DI + CT was the most likely to be the optimal strategy in reducing MA occurrence and improving LVEF. CT was likely the most effective strategy in reducing bleeding events. However, DI + CT exhibited the least favorable safety.Conclusion: TCMI-IBCs + CT had potential benefits in the treatment of AMI. STSI + CT showed the most favorable performance in treating AMI, followed by DI combined with CT.Systematic Review Registration:https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=384067, identifier CRD42022384067.
Muscle reoxygenation is slower after higher cycling intensity, and is faster and more reliable in locomotor than in accessory muscle sites
Authors: Arnold Jem I. , Yogev Assaf , Nelson Hannah , van Hooff Martijn , Koehle Michael S. 
Published: August 2024

IntroductionWearable near-infrared spectroscopy (NIRS) can be used during dynamic exercise to reflect the balance of muscle oxygen delivery and uptake. This study describes the behaviour and reliability of postexercise reoxygenation with NIRS as a function of exercise intensity at four muscle sites during an incremental cycling test. We discuss physiological components of faster and slower reoxygenation kinetics in the context of sport science and clinical applications. We hypothesised that reoxygenation would be slower at higher intensity, and that locomotor muscles would be faster than accessory muscles. We quantified test-retest reliability and agreement for each site.MethodsTwenty-one trained cyclists performed two trials of an incremental cycling protocol with 5-min work stages and 1-min rest between stages. NIRS was recorded from the locomotor vastus lateralis and rectus femoris muscles, and accessory lumbar paraspinal and lateral deltoid muscles. Reoxygenation time course was analysed as the half-recovery time (HRT) from the end of work to half of the peak reoxygenation amplitude during rest. Coefficient of variability (CV) between participants, standard error of the measurement (SEM) within participants, and intraclass correlation coefficient (ICC) for test-retest reliability were evaluated at 50%, 75%, and 100% peak workloads. A linear mixed-effects model was used to compare differences between workloads and muscle sites.ResultsHRT was slower with increasing workload in the VL, RF, and PS, but not DL. VL had the fastest reoxygenation (lowest HRT) across muscle sites at all workloads (HRT = 8, 12, 17 s at 50%, 75%, 100% workload, respectively). VL also had the greatest reliability and agreement. HRT was sequentially slower between muscle sites in the order of VL &lt; RF &lt; PS &lt; DL, and reliability was lower than for the VL.DiscussionThis study highlights the potential for using wearable NIRS on multiple muscle sites during exercise. Reoxygenation kinetics differ between local muscle sites with increasing intensity. Moderate-to-good reliability in the VL support its increasing use in sport science and clinical applications. Lower reliability in other muscle sites suggest they are not appropriate to be used alone, but may add information when combined to better reflect systemic intensity and fatigue during exercise at different intensities.
The effect of contextual interference on transfer in motor learning - a systematic review and meta-analysis
Authors: Czyż Stanisław H. , Wójcik Aleksandra M. , Solarská Petra 
Published: August 2024

Since the initial study on contextual interference (CI) in 1966, research has explored how practice schedules impact retention and transfer. Apart from support from scientists and practitioners, the CI effect has also faced skepticism. Therefore, we aimed to review the existing literature on the CI effect and determine how it affects transfer in laboratory and applied settings and in different age groups. We found 1,287 articles in the following databases: Scopus, EBSCO, Web of Science, ScienceDirect, supplemented by the Google Scholar search engine and manual search. Of 300 fully screened articles, 42 studies were included in the systematic review and 34 in the quantitative analysis (meta-analysis). The overall CI effect on transfer in motor learning was medium (SMD = 0.55), favoring random practice. Random practice was favored in the laboratory and applied settings. However, in laboratory studies, the medium effect size was statistically significant (SMD = 0.75), whereas, in applied studies, the effect size was small and statistically non-significant (SMD = 0.34). Age group analysis turned out to be significant only in adults and older adults. In both, the random practice was favored. In adults, the effect was medium (SMD = 0.54), whereas in older adults was large (SMD = 1.28). In young participants, the effect size was negligible (SMD = 0.12).Systematic review registration:https://clinicaltrials.gov/, identifier CRD42021228267.
Evaluation of professional satisfaction of audiologists working in Türkiye based on their personality characteristics and sector of work
Authors: Çelikgün Bahtiyar , Büyükkal Furkan , Minga Recep , Ölçek Gül 
Published: August 2024

PurposeThis study investigates the relationship between audiologists' personality traits and professional satisfaction.DesignBig Five-50 Personality Traits and Professional Satisfaction Scale was used to examine the relationship between audiologists' personality traits and professional satisfaction. Statistical analyzes were performed with SPSS and AMOS programs.Study exampleThis study examines 167 audiologists who completed a minimum of an undergraduate program in audiology before the professional field.ResultsThe results of confirmatory factor analysis indicate that both scales are reliable and valid. There is a significant relationship between extraversion, agreeableness, conscientiousness, and emotional stability and occupational satisfaction. However, there is no significant relationship between intelligence/imagination and professional satisfaction.ConclusionsExtraversion, agreeableness, conscientiousness, emotional stability/neuroticism affect job satisfaction. Understanding these dynamics can inform strategies that will increase the professional wellbeing and productivity of audiologists.
Examining the influence of problematic internet use on sleep quality in Chinese adolescents: a study using the extended Stressor-Strain-Outcome (SSO) model
Authors: Gong Zhuliu , Guo Yi , Fan Siyuan , Sun Xinying , Wu Yibo 
Published: August 2024

ObjectiveThis study aims to explore how problematic internet use may affect the sleep quality of Chinese adolescents using the extended Stressor-Strain-Outcome (SSO) model. The model posits that stressors indirectly influence behavioral outcomes through the mediation of emotional and physiological strain responses.MethodA sample of 4,365 adolescents in China participated in this study, which utilized questionnaires and other methods to develop a novel SSO model. In this model, problematic internet use was considered as the stressor, anxiety as an indicator of tension, and sleep quality as the ultimate outcome. Family health was introduced as a moderating variable.ResultsThe study found that problematic internet use can significantly and positively predict adolescents’ anxiety (β = 0.132, p &lt; 0.001) and sleep quality (β = 0.362, p &lt; 0.001). Furthermore, anxiety was identified as a significant mediating factor between problematic internet use and sleep quality [Effect = 0.066, p &lt; 0.05, 95% CI (0.014, −0.0018)]. Family health was observed to have a moderating effect on the relationship between problematic internet use and anxiety (β = −0.075, p &lt; 0.001).ConclusionThe research indicates that problematic internet use not only directly increases individual anxiety as a stressor but also indirectly impacts sleep quality by exacerbating anxiety. However, a positive family health status can effectively moderate the adverse impact of problematic internet use on anxiety.