bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel online enfacement illusion for investigating self-perception in mental disorders: an experimental study protocol
Authors: Portingale Jade , Butler David , Krug Isabel 
Published: July 2024

Abstract
Background
Remote research methods and interventions for mental health disorders have become increasingly important, particularly for conditions like eating disorders (EDs). Embodiment illusions, which induce feelings of ownership over another person?s body or body parts, offer valuable insights into the mechanisms underlying self-perception issues in EDs and potential interventions. However, existing research using these illusions has been limited to face-to-face settings. We illustrate a novel online protocol to induce the enfacement illusion (embodiment illusion principles applied to one’s face) in an ED-based sample.

Methods
Participants complete a 2-hr virtual session with a researcher. First, baseline trait/state ED psychopathology measures and a self-face recognition task occur. Second, participants experience two testing blocks of the enfacement illusion involving synchronously and asynchronously mimicking a pre-recorded actor’s facial expressions. After each block, subjective and objective enfacement illusion measures occur alongside state ED psychopathology reassessment.

Discussion
Successfully inducing enfacement illusions online could provide an affordable, accessible virtual approach to further elucidate the mechanistic role of self-perception disturbances across psychopathologies such as EDs. Moreover, this protocol may represent an innovative, remotely-delivered intervention strategy, as ‘enfacement’ over another face could update negative self-representations in a cost-effective, scalable manner.
Review on radiomic analysis in 18F-fluorodeoxyglucose positron emission tomography for prediction of melanoma outcomes
Authors: Amrane Karim , Meur Coline Le , Thuillier Philippe , Berthou Christian , Uguen Arnaud , Deandreis Désirée , Bourhis David , Bourbonne Vincent , Abgral Ronan 
Published: July 2024

AbstractOver the past decade, several strategies have revolutionized the clinical management of patients with cutaneous melanoma (CM), including immunotherapy and targeted tyrosine kinase inhibitor (TKI)-based therapies. Indeed, immune checkpoint inhibitors (ICIs), alone or in combination, represent the standard of care for patients with advanced disease without an actionable mutation. Notably BRAF combined with MEK inhibitors represent the therapeutic standard for disease disclosing BRAF mutation. At the same time, FDG PET/CT has become part of the routine staging and evaluation of patients with cutaneous melanoma. There is growing interest in using FDG PET/CT measurements to predict response to ICI therapy and/or target therapy. While semiquantitative values such as standardized uptake value (SUV) are limited for predicting outcome, new measures including tumor metabolic volume, total lesion glycolysis and radiomics seem promising as potential imaging biomarkers for nuclear medicine. The aim of this review, prepared by an interdisciplinary group of experts, is to take stock of the current literature on radiomics approaches that could improve outcomes in CM.
Beyond microroughness: novel approaches to navigate osteoblast activity on implant surfaces
Authors: Matsuura Takanori , Komatsu Keiji , Cheng James , Park Gunwoo , Ogawa Takahiro 
Published: July 2024

AbstractConsidering the biological activity of osteoblasts is crucial when devising new approaches to enhance the osseointegration of implant surfaces, as their behavior profoundly influences clinical outcomes. An established inverse correlation exists between osteoblast proliferation and their functional differentiation, which constrains the rapid generation of a significant amount of bone. Examining the surface morphology of implants reveals that roughened titanium surfaces facilitate rapid but thin bone formation, whereas smooth, machined surfaces promote greater volumes of bone formation albeit at a slower pace. Consequently, osteoblasts differentiate faster on roughened surfaces but at the expense of proliferation speed. Moreover, the attachment and initial spreading behavior of osteoblasts are notably compromised on microrough surfaces. This review delves into our current understanding and recent advances in nanonodular texturing, meso-scale texturing, and UV photofunctionalization as potential strategies to address the “biological dilemma” of osteoblast kinetics, aiming to improve the quality and quantity of osseointegration. We discuss how these topographical and physicochemical strategies effectively mitigate and even overcome the dichotomy of osteoblast behavior and the biological challenges posed by microrough surfaces. Indeed, surfaces modified with these strategies exhibit enhanced recruitment, attachment, spread, and proliferation of osteoblasts compared to smooth surfaces, while maintaining or amplifying the inherent advantage of cell differentiation. These technology platforms suggest promising avenues for the development of future implants.
Early detection of tuberculosis: a systematic review
Authors: Yayan Josef , Franke Karl-Josef , Berger Melanie , Windisch Wolfram , Rasche Kurt 
Published: July 2024

AbstractTuberculosis remains a significant global health challenge. Tuberculosis affects millions of individuals worldwide. Early detection of tuberculosis plays a relevant role in the management of treatment of tuberculosis. This systematic review will analyze the findings of several published studies on the topic of the early detection of tuberculosis. This systematic review highlights their methodologies and limitations as well as their contributions to our understanding of this pressing issue. Early detection of tuberculosis can be achieved through tuberculosis screening for contacts. Comprehensive health education for household contacts can be used as early detection. The in-house deep learning models can be used in the X-ray used for automatic detection of tuberculosis. Interferon gamma release assay, routine passive and active case detection, portable X-ray and nucleic acid amplification testing, and highly sensitive enzyme-linked immunosorbent assay tests play critical roles in improving tuberculosis detection.
Sample size calculation for data reliability and diagnostic performance: a go-to review
Authors: Monti Caterina Beatrice , Ambrogi Federico , Sardanelli Francesco 
Published: July 2024

AbstractSample size, namely the number of subjects that should be included in a study to reach the desired endpoint and statistical power, is a fundamental concept of scientific research. Indeed, sample size must be planned a priori, and tailored to the main endpoint of the study, to avoid including too many subjects, thus possibly exposing them to additional risks while also wasting time and resources, or too few subjects, failing to reach the desired purpose. We offer a simple, go-to review of methods for sample size calculation for studies concerning data reliability (repeatability/reproducibility) and diagnostic performance. For studies concerning data reliability, we considered Cohen’s κ or intraclass correlation coefficient (ICC) for hypothesis testing, estimation of Cohen’s κ or ICC, and Bland-Altman analyses. With regards to diagnostic performance, we considered accuracy or sensitivity/specificity versus reference standards, the comparison of diagnostic performances, and the comparisons of areas under the receiver operating characteristics curve. Finally, we considered the special cases of dropouts or retrospective case exclusions, multiple endpoints, lack of prior data estimates, and the selection of unusual thresholds for α and β errors. For the most frequent cases, we provide example of software freely available on the Internet.Relevance statement Sample size calculation is a fundamental factor influencing the quality of studies on repeatability/reproducibility and diagnostic performance in radiology.Key points• Sample size is a concept related to precision and statistical power.• It has ethical implications, especially when patients are exposed to risks.• Sample size should always be calculated before starting a study.• This review offers simple, go-to methods for sample size calculations.
Graphical Abstract
The potential of neuroscience in transforming business: a meta-analysis
Authors: Khaneja Supriya , Arora Tushar 
Published: July 2024

AbstractOrganizations that embrace innovative business strategies position themselves well for success. In this evolving technological landscape, businesses are increasingly focused on understanding consumer behaviors and preferences to tailor their products and services effectively. Notably, integrating neuroscience has become pivotal in achieving these goals, requiring its incorporation throughout various business processes. This comprehensive research review conducts a meta-analysis, synthesizing findings from numerous studies on applying neuroscience across diverse business domains. The primary objective is to identify innovative neuroscience approaches that can significantly revolutionize businesses. Through a meticulous literature exploration using PRISMA analysis, we discerned broad themes and further refined them into critical sub-themes. This thematic categorization enables a focused examination of each area of business research. The findings in this study uncovered vital intersections between neuroscience and business, offering valuable insights for corporations and researchers. In essence, the integration of neuroscientific techniques and artificial intelligence (AI)-based softwares into business practices is no longer optional, but a necessity for businesses to stay competitive in today’s fast-paced world. This study, therefore, plays a crucial role in connecting the state-of-the-art tools and techniques in neuroscience and traditional business practices. It paves the way for a new era of business operations, where science and technology work hand in hand with commerce to create a more prosperous and sustainable future. In conclusion, the paper emphasizes the importance of incorporating neuroscience techniques and newly developed AI-based softwares into business practices. This integration can yield precise and favorable outcomes, offering businesses the tools to thrive in an ever-changing market environment.
CLAMP: A phase II prospective study of camrelizumab combined with pegaspargase, etoposide, and high-dose methotrexate in patients with natural killer (NK)/T-cell lymphoma.
Authors: Liu Tao , Li Qiuhui , Mao Xia , Zhou Haibo , Dong Youhong , Zhu Fang , Liu Xinxiu , Wu Gang , Xiao Min , Zhang Liling 
Published: July 2024

7002 Background: Immune checkpoint blockades have been investigated and show promising results in natural killer (NK)/T-cell lymphoma (NKTCL) patients. This study explored the efficacy and safety of camrelizumab, a PD-1 monoclonal antibody, combined with pegaspargase, etoposide, and high-dose methotrexate (CLAMP) in the treatment of NKTCL patients. Methods: This single-arm, phase 2 study enrolled patients with NKTCL. Patients were divided into two groups: group A, early-stage (Ann Arbor staging I/II) patients; group B, advanced-stage (Ann Arbor staging III/IV) and RR patients. Group A received involved-field radiotherapy combined with 3-4 cycles of CLAMP treatment. Group B received 6 cycles of CLAMP treatment. CLAMP regimen was administrated as follows: pegaspargase 2500 U/m2 d1, etoposide 100 mg/m2 per day d1-3, HD-MTX 3 g/m2 d4, camrelizumab 200 mg d7. Results: A total of 41 patients, including 36 newly diagnosed and 5 relapsed NKTCL, were enrolled in this study from July 2020 to December 2022. 14 patients presented with high-risk central nervous system (CNS) infiltration with 2-4 risk factors of the NKPI (Ann Arbor stage III or IV, presence of B symptoms, regional lymph node involvement, elevated lactate dehydrogenase). One patient had complied hemophagocytic lymphohistiocytosis (HLH). On treatment completion, the overall cohort showed a complete remission (CR) rate of 87.80% (36/41) and a partial remission (PR) rate of 7.32% (3/41), giving an overall response rate (ORR) of 95.12% (39/41). The ORR for group A patients was 100% (19/19) and 90.91% (20/22) for group B patients; only 2 patients in group B progressed during the treatment. The patient with HLH obtained CR and was disease-free for more than 12 months. No patients developed HLH or CNS involvement during the follow-up period. At a median follow-up of 21 months, 5 patients (12.20%) died; among them, 3 patients died of disease progression, and 2 patients died of infection unrelated to treatment. The 2-year progression-free survival (PFS) and 2-year overall survival (OS) rates for the whole cohort were 72.81% and 88.03%, respectively. The 2-year PFS rates for group A and group B were 91.67% and 53.83%, respectively. The 2-year OS rates for group A and group B were 91.67% and 77.53%, respectively. Hematologic toxicity was common, yet nonhematologic toxicity was mild and could be well controlled by supportive treatments, except 2 patients had delayed methotrexate metabolism and received dialysis. No treatment-related death was observed. Conclusions: The CLAMP regimen is effective and safe and seems to reduce the incidence of CNS involvement and HLH. The CLAMP regimen may be a promising option in the treatment of NKTCL lymphoma. Clinical trial information: ChiCTR2100051208.
Phase I trial of CRD3874-SI, a systemically administered STING agonist, in patients with advanced solid tumors.
Authors: Kelly Ciara Marie , Avutu Viswatej , Banks Lauren Baker , Chan Jason Earl , Chi Ping , Clark Camron , Counihan Olivia , Dickson Mark Andrew , Gounder Mrinal M. , Keohan Mary Louise , Maki Robert G. , Movva Sujana , Reed Damon R. , Rosenbaum Evan , Szostek Anna , Qin Li-Xuan , Wong Phillip , Tap William D. , D'Angelo Sandra P. 
Published: July 2024

TPS2690 Background: Identifying novel approaches that harness and augment anti-tumor immune responses represents an important area of ongoing research and drug development. Stimulator of interferon genes (STING) is an endoplasmic protein receptor that acts as an innate immune mediator by generating protective type 1 interferons when cytosolic DNA is detected in cells. STING also channels protons across golgi membranes promoting autophagy and pyroptosis. CRD3874-SI is a first in class small molecule allosteric STING agonist and potent activator of all five human STING variants that promotes the release of inflammatory cytokines from downstream interferon genes. It has demonstrated promising pre-clinical anti-cancer activity in several tumor mouse models. CRD3874-SI demonstrated high levels of systemic safety in cynomolgus monkeys, thought to be related to its ability to inhibit STING proton channel activity. Methods: This is a single institution, phase 1a/b study of CRD3874-SI in patients with advanced sarcoma and Merkel cell carcinoma who have received at least one line of prior therapy. The dose escalation phase will explore the safety and tolerability of CRD3874-SI across 6 dose levels following a standard 3+3 design. Dose expansion in subtype specific sarcoma and Merkel cell carcinoma is planned on completion of the dose escalation phase of the study. CRD3874-SI will be administered by intravenous infusion once per week for 2 cycles. From cycle 3 onwards, participants will receive three consecutive weekly infusions followed by one week break, over a 28-day treatment cycle. The primary objective is to assess the safety and tolerability of CRD3874-SI by determining the maximum tolerated dose, recommended phase 2 dose and schedule of administration. Secondary objectives include further defining the safety profile, examining the pharmacokinetics and pharmacodynamics (CXCL10 analysis) of CRD3874-SI and evaluating the efficacy of CRD3874-SI as determined by best objective response rate and clinical benefit rate per RECIST v 1.1. Treatment will continue for up 6 cycles or until disease progression or unacceptable toxicity. Cross sectional imaging will be used to measure clinical activity. Adverse events will be evaluated using NCI-CTCAE v5.0 criteria. This study is currently open to enrollment and dosing has commenced. Clinical trial information: NCT06021626 .
Multistaged Stereotactic Radiosurgery for Complex Large Lobar Arteriovenous Malformations: A Case Series
Authors: Yurtluk Mehmet Denizhan , Bin-Alamer Othman , Flickinger John C. , Hadjipanayis Constantinos G. , Niranjan Ajay , Lunsford L. Dade 
Published: July 2024

BACKGROUND AND OBJECTIVES:
Although stereotactic radiosurgery (SRS) has well defined outcomes in the management of smaller-volume arteriovenous malformations (AVM), this report evaluates the outcomes when SRS is used for large-volume (≥10 cc) lobar AVMs.

METHODS:
Between 1990 and 2022, a cohort of 1325 patients underwent Leksell Gamma Knife SRS for brain AVMs. Among these, 40 patients (25 women; median age: 37 years) with large lobar AVMs underwent volume-staged SRS followed by additional SRS procedures if needed (2-5 procedures). The patients presented with diverse AVM locations and Spetzler-Martin Grades. Before SRS, 16 patients underwent a total of 43 embolization procedures.

RESULTS:
Over a median follow-up of 73 months, 20 patients achieved AVM obliteration. The 3, 5, and 10-year obliteration rates were 9.3%, 15.3%, and 53.3%, respectively. During the latency interval between the first SRS procedure and the last follow-up, 11 patients had intracerebral hemorrhages (ICH) and 6 developed new neurological deficits unrelated to ICH. The postoperative hemorrhage risk after the first SRS was 13.8% at 3 years, 16.6% at 5 years, and 36.2% at 10 years. No hemorrhagic event was documented after confirmed obliteration. Compared with the modified Rankin Scale (mRS) scores before SRS, the mRS improved or remained stable in 28 patients. Nine patients died during the observation interval. Five were related to ICH.

CONCLUSION:
These outcomes underscore both the potential effectiveness and the limitations of multistage SRS procedures for complex high-risk large volume AVMs in critical brain lobar locations. Most patients retained either stable or improved long-term mRS scores. During the latency interval from the first SRS until obliteration, achieved after two or more procedures, the risk of hemorrhage and treatment-related complications persists.
Comparative Anatomy of the Contralateral Transmaxillary Approach Alone and With Ipsilateral Transpterygoid Extension: Quantitative Insights on Surgical Exposure and Maneuverability in the Petroclival Region
Authors: Gattozzi Domenico A. , Hosokawa Patrick W. , Martinez-Perez Rafael , Youssef A. Samy 
Published: July 2024

BACKGROUND AND OBJECTIVES:
Beyond qualitative evidence legitimizing endoscopic corridors through contralateral transmaxillary (CTM) and endonasal ipsilateral transpterygoid (ITP) corridors to the petrous apex and petroclival region, surgical feasibility by direct quantitative comparative anatomy is sparse. Our cadaveric study addresses this by performing the CTM approach followed by ITP extension to quantify the extent of petrous apex resection, instrument maneuverability, and working distance to petrous apex.

METHODS:
Anatomic dissections were performed bilaterally on 5 latex-injected human cadaveric heads (10 petrous bones). After CTM dissections were quantified, the ITP approach was added enlarging initial exposure. Differences were measured with statistical significance when P values are < .05.

RESULTS:
The mean petrosectomy volume was 0.958 cm3 with CTM and 1.987 cm3 with CTM + ITP, corresponding to 14.53% and 30.52% petrous apex resection, respectively. Craniocaudal instrument mobility was more limited in the lateral extent of dissection compared with the midline for both CTM (8.062° vs 14.416°) and CTM + ITP (5.4° vs 14.4°). The CTM approach achieved the lateral-most dissection at the body of the petrous apex (15.936 mm), with lateralization more limited in the superior petroclival region (9.628 mm) and the inferior petroclival region (8.508 mm). Angle of surgical maneuverability increased superiorly vs inferiorly in the CTM approach (mean 12.596° vs 8.336°, respectively). The CTM approach offered the shortest mean working distance (88.624 mm) to the petroclival region compared with the bi-nares approach (100.5 mm). CTM + ITP achieved greater lateralization in the superior (21.237 mm) and inferior (22.087 mm) aspects of the petroclival region compared with the CTM approach.

CONCLUSION:
Operative considerations are discussed in accessing target neurovascular structures through the uniquely shaped corridors formed by the CTM or combined CTM + ITP. Allowing mobilization of the internal carotid artery laterally and eustachian tube inferiorly, addition of the ITP allowed for larger petrosectomy than CTM alone, especially in the inferior and lateral aspects of the petrous bone.
The Endoscopic Transorbital Approach for Vascular Surgery: An Anterior Circulation Anatomic Study, 2-Dimensional Operative Video
Authors: Plata-Bello Julio , Mosteiro-Cadaval Alejandra , Manfrellotti Roberto , Torné Ramón , Perelló Maria Antonia , Prats-Galino Alberto , Di Somma Alberto , Enseñat Joaquim 
Published: July 2024

BACKGROUND AND OBJECTIVES:
Minimally invasive endoscopic approaches in cranial base surgery have been developing in the past decades. The transorbital (TO) route is one promising alternative, yet its adequacy for intracranial vascular lesions remains unclear. The present anatomic work aimed to test the feasibility and to provide a qualitative description of the endoscopic TO approach for the anterior circulation, namely the internal carotid artery and the middle cerebral artery.

METHODS:
Seven embalmed adult cadaveric specimens (12 sides) were used in the study. Each side was approached in 3 successive steps: (1) Superior-eyelid TO approach, with great and lesser sphenoid wing removal. (2) Removal of anterior clinoid process (ACP). (3) Removal of the lateral orbital rim. All the procedures were performed under endoscopic view.

RESULTS:
The TO approach without removing the ACP allowed to dissect the sphenoidal and lateral segments of the Sylvian fissure with an adequate identification of the middle cerebral artery bifurcation in all specimens. The removal of the ACP allowed further dissection toward the opticocarotid cistern, with the identification of the ophthalmic, posterior communicating, and the anterior choroidal arteries. The internal carotid artery bifurcation and A1 segment were also readily identified. Finally, removal of the lateral orbital rim provided a wider and more comfortable access to the above-mentioned vascular structures.

CONCLUSION:
According to our anatomic data, the TO approach can be used to reach the main vascular components of the anterior circulation. This opens the field for exploring its application in the treatment of vascular pathology, particularly aneurysms.