bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global research in schizophrenia and serotonin: a bibliometric analysis
Authors: Canul-Medina Gustavo , López-Pech Gael , Jiménez-Trejo Francisco 
Published: August 2024

BackgroundSchizophrenia is a chronic mental illness that affects millions of individuals worldwide. The etiological origin of schizophrenia is heterogeneous, but it has been shown to be associated with dysfunction in serotonin activity, serotonin receptors, and serotonin metabolism in the brain. Bibliometric analysis is a tool used to scrutinise and analyse research activities and evidence in a specific research area. No existing bibliometric analyses have considered both serotonin and schizophrenia.MethodsWe conducted a bibliometric analysis including 12,027 studies related to the schizophrenia–serotonin link published from the inception of the study to 2023 and available in the Scopus database. We used VOSviewer software to identify global trends, analyse the author and editors keywords, the most cited articles and author, as well as the most productive institutes and journals publishing research on schizophrenia–serotonin link.ResultsMost publications related to the link between schizophrenia and serotonin are focused on adult humans and examine topics such as antipsychotic agents, depression, and serotonin uptake inhibitors. The Journal of Clinical Psychiatry has published the most papers on the schizophrenia–serotonin relationship. Among nations, the United States is the leader in publications. King’s College London is the institution with the highest number of publications, and H. Y. Meltzer is the most influential author. Growing trends in schizophrenia–serotonin research are personalised medicine, alternative medicine, transcranial magnetic stimulation, artificial intelligence, nervous system inflammation, brain-gut axis, and the gut microbiome.ConclusionSince 1950, there have been several fluctuations in the number of published studies related to schizophrenia and serotonin. We believe that the development of novel medications and treatments for schizophrenia will be increased in the future, as well as research into genetic risks, psychological factors, and cranial neuroimaging components. Future schizophrenia and serotonin research is likely to focus on personalised medicine, alternative therapies, novel pathogenesis of schizophrenia, and the use of emerging technologies such as artificial intelligence.
Predictive modeling and socioeconomic determinants of diarrhea in children under five in the Amhara Region, Ethiopia
Authors: Kassaw Abdulaziz Kebede , Alebachew Muluneh Ayana , Assefa Ebrahim Msaye , Yimer Ali 
Published: August 2024

BackgroundDiarrheal disease, characterized by high morbidity and mortality rates, continues to be a serious public health concern, especially in developing nations such as Ethiopia. The significant burden it imposes on these countries underscores the importance of identifying predictors of diarrhea. The use of machine learning techniques to identify significant predictors of diarrhea in children under the age of 5 in Ethiopia’s Amhara Region is not well documented. Therefore, this study aimed to clarify these issues.MethodsThis study’s data have been extracted from the Ethiopian Population and Health Survey. We have applied machine learning ensemble classifier models such as random forests, logistic regression, K-nearest neighbors, decision trees, support vector machines, gradient boosting, and naive Bayes models to predict the determinants of diarrhea in children under the age of 5 in Ethiopia. Finally, Shapley Additive exPlanation (SHAP) value analysis was performed to predict diarrhea.ResultAmong the seven models used, the random forest algorithm showed the highest accuracy in predicting diarrheal disease with an accuracy rate of 81.03% and an area under the curve of 86.50%. The following factors were investigated: families who had richest wealth status (log odd of −0.04), children without a history of Acute Respiratory Infections (ARIs) (log odd of −0.08), mothers who did not have a job (log odd of −0.04), children aged between 23 and 36 months (log odd of −0.03), mothers with higher education (log odds ratio of −0.03), urban dwellers (log odd of −0.01), families using electricity as cooking material (log odd of −0.12), children under 5 years of age living in the Amhara region of Ethiopia who did not show signs of wasting, children under 5 years of age who had not taken medications for intestinal parasites unlike their peers and who showed a significant association with diarrheal disease.ConclusionWe recommend implementing programs to reduce the incidence of diarrhea in children under the age of 5 in the Amhara region. These programs should focus on removing socioeconomic barriers that impede mothers’ access to wealth, a favorable work environment, cooking fuel, education, and healthcare for their children.
The clinical value of inflammation index in predicting ICU mortality of critically ill patients with intracerebral hemorrhage
Authors: Zhao Guang , Gu Yuting , Wang Zhaoxiang , Chen Yuyang , Xia Xiaohua 
Published: August 2024

BackgroundThe inflammatory response holds paramount significance in the context of intracerebral hemorrhage (ICH) and exhibits a robust correlation with mortality rates. Biological markers such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune inflammation index (SII), and systemic inflammatory response index (SIRI) play crucial roles in influencing the systemic inflammatory response following ICH. This study aims to compare the predictive efficacy of NLR, PLR, LMR, SII, and SIRI concerning the risk of mortality in the intensive care unit (ICU) among critically ill patients with ICH. Such a comparison seeks to elucidate their early warning capabilities in the management and treatment of ICH.MethodsPatients with severe ICH requiring admission to the ICU were screened from the Medical Information Marketplace for Intensive Care (MIMIC-IV) database. The outcomes studied included ICU mortality and 30 day ICU hospitalization rates, based on tertiles of the NLR index level. To explore the relationship between the NLR index and clinical outcomes in critically ill patients with ICH, we utilized receiver operating characteristic (ROC) analysis, decision curve analysis (DCA), and multivariate logistic regression analysis.ResultsA total of 869 patients (51.9% male) were included in the study, with an ICU mortality rate of 22.9% and a 30 day ICU hospitalization rate of 98.4%. Among the five indicators examined, both the ROC curve and DCA indicated that NLR (AUC: 0.660, 95%CI: 0.617–0.703) had the highest predictive ability for ICU mortality. Moreover, this association remained significant even after adjusting for other confounding factors during multivariate analysis (HR: 3.520, 95%CI: 2.039–6.077). Based on the results of the multivariate analysis, incorporating age, albumin, lactic acid, NLR, and GCS score as variables, we developed a nomogram to predict ICU mortality in critically ill patients with ICH.ConclusionNLR emerges as the most effective predictor of ICU mortality risk among critically ill patients grappling with ICH when compared to the other four indicators. Furthermore, the integration of albumin and lactic acid indicators into the NLR nomogram enhances the ability to promptly identify ICU mortality in individuals facing severe ICH.
The role of digital financial inclusion in China on urban—rural disparities in healthcare expenditures
Authors: Zhang Yuyang , Li Keyi , Pang Yumeng , Coyte Peter C. 
Published: August 2024

IntroductionThe digital financial inclusion (DFI) provides opportunities to improve the relative capacity to pay for healthcare services by rural residents who are usually underserved by traditional finance in China. This paper provides empirical evidence on how the development of DFI affects the healthcare expenditure disparities between urban and rural residents.MethodsWe employed the fixed effects model and instrumental variable method to estimate the impact of DFI on the Theil index of urban–rural disparities in healthcare expenditures, using panel data from 31 provinces (2011 ~ 2020) in China. We further adopted a moderating effect model to test whether the intensity of the impact would vary depending on the level of local government health expenditures.ResultsThe results suggest a negative association between the development level of DFI and the urban–rural healthcare expenditure disparities in China. For every 1% increase in the DFI index, the Theil index of urban–rural disparities in healthcare expenditures would fall by 0.0013. After changing the measurement method for the dependent variable and adjusting the sample, the results remain robust. Moreover, the result of the moderating effect model indicates that, a high level of government health expenditures is conducive to the impact of DFI.DiscussionOur research reveals that DFI plays an important role in bridging the urban–rural gap in healthcare expenditures. This finding provides new information for addressing the issue of urban–rural healthcare inequality in China. Chinese government needs to accelerate the construction of digital infrastructure and increase the penetration rate of digital tools in rural areas to promote the beneficial effects of DFI. Additionally, it is also necessary for local government to address the unbalanced allocation of medical resources between urban and rural areas, especially the shortage of rural human resources.
Association of the severity and progression rate of periodontitis with systemic medication intake
Authors: Batista-Cárdenas Daniela , Araya-Castillo Agatha , Arias-Campos María Paula , Solís-Rivera Ana Paula , Jiménez-Matarrita Jeniffer , Piedra-Hernández Lucía , Madriz-Montero Luis , Ramírez Karol 
Published: August 2024

Background/purposeInformation on the systemic medication profiles of patients with periodontitis is limited. Therefore, this retrospective cross-sectional study aimed to analyze the relationship between the severity and rate of progression of periodontitis and systemic medication intake using a database of patients who attended the Clinic of Periodontics of the Faculty of Dentistry of the University of Costa Rica.MethodsElectronic health records of patients diagnosed with periodontitis based on the Classification of Periodontal and Peri-Implant Diseases and Conditions (2017) were evaluated. Individuals were further categorized based on the severity (stage) and rate of progression (grade). Data extracted from the patient records included age, sex, and self-reported medication intake.ResultsIn total, 930 records were included. Most of the studied population was middle-aged (36–64 years old); 43.01% were male, and 56.99% were female. Four hundred and fifty-seven patients (49.14%) reported taking at least one systemic medication for a chronic condition. Regarding the periodontal treatment phase, 62.37% underwent steps 1–3, and 37.63% underwent step 4. The most common systemic medications taken were for cardiovascular diseases (42.28%), followed by medications for diabetes (14.46%) and neurologic disorders (14.46%). Most patients (59.35%) were diagnosed with Stage III periodontitis. Grade B (48.28%) was the most prevalent. Calcium channel blockers demonstrated a disease severity-dependent association with the periodontal stage (p = 0.021). In addition, systemic medications for diabetes mellitus were associated with periodontal disease severity and rate of progression (all Ps &lt; 0.05).ConclusionsThis study provides indirect evidence of the association between systemic diseases and periodontitis. The positive association between medications used to treat diabetes and the severity and rate of progression of periodontitis may be due to the underlying disease rather than the medications per se.
Prevalence of Respiratory Pathogens in Nasopharyngeal Swabs of Febrile Patients with or without Respiratory Symptoms in the Niakhar Area of Rural Senegal
Authors: Ndiaye Dame , Diatta Georges , Bassene Hubert , Cortaredona Sébastien , Sambou Masse , Ndiaye Anna Julienne Selbe , Bedotto-Buffet Marielle , Edouard Sophie , Mediannikov Oleg , Sokhna Cheikh , Fenollar Florence 
Published: August 2024

Acute respiratory tract infections are one of the leading causes of morbidity and mortality worldwide. More data are needed on circulating respiratory microorganisms in different geographical areas and ecosystems. We analyzed nasopharyngeal swabs from 500 febrile patients living in the Niakhar area (Senegal), using FTDTM multiplex qPCR and simplex qPCR to target a panel of 25 microorganisms. We detected at least one microorganism for 366/500 patients (73.2%), at least one virus for 193/500 (38.6%), and at least one bacterium for 324/500 (64.8%). The most frequently detected microorganisms were Streptococcus pneumoniae (36.8%), Haemophilus influenzae (35.8%), adenovirus (11.8%), influenza viruses (6.4%), rhinovirus (5.0%), SARS-CoV-2 (4.0%), and RSV (4.0%). The main microorganisms significantly associated with respiratory symptoms, with a p-value ≤ 0.05, were influenza virus (11.9% in patients with respiratory symptoms versus 2.9% in patients without), RSV (6.5% versus 2.6%), metapneumovirus (5.4% versus 1.3%), HPIVs (7.6% versus 1.0%), S. pneumoniae (51.9% versus 28.0%), and H. influenzae (54.6% versus 24.5%). Co-infections were significantly associated with respiratory symptoms (65.4% versus 32.9%). All the epidemiological data show a high level of circulation of respiratory pathogens among febrile patients, including those preventable by vaccination such as S. pneumoniae, raising the question of the serotypes currently circulating. Furthermore, the availability of affordable real-time etiological diagnostic tools would enable management to be adapted as effectively as possible.
Improving discharge summaries from hospital with a brief recommendation text box: results from a nationwide survey
Authors: Mikkelsen Thorbjørn H , Nielsen Jesper B , Storsveen Maria M , Søndergaard Jens 
Published: August 2024

Background
Danish hospital physicians are obliged to mark discharge summaries addressing whether the GP is recommended to follow up the patient, as well as stating suggested follow-up actions in a recommendation text box.

Aim
To investigate GPs’ experiences with the recommendation text box in discharge summaries.

Design & setting
A questionnaire was sent to a representative sample of GPs in Denmark in January 2021.

Method
A questionnaire was prepared for GPs based on background material, focus group interviews, and discussions with GPs and hospital physicians. It was subsequently pilot-tested by fellow researchers and GPs, and revised before the survey.

Results
Seventy-two per cent of the GPs surveyed ‘totally agree' or 'partly agree’ that the recommendation text box is easy to find. In addition, our results show significant differences on how difficult the recommendation box is to find on different software. Sixty-three per cent ‘totally agree’ or ‘partly agree’ that the recommendation text box provides brief and precise information about the recommended follow-up.

Conclusion
GPs generally find that the recommendation text box provides them with brief and precise information about the recommended follow-up. In addition, the software used by the GPs has a significant influence on how the recommendation text box is to find.
Reabsorção intracoronária pré-eruptiva: revisão integrativa da literatura
Authors: Matos Ester Ferreira , Gomes Janaína Cristina , Lima Laura Jordana Santos , Soares Maria Eliza da Consolação 
Published: August 2024

Reabsorção intracoronária pré-eruptiva (RIPE) é caracterizada como uma lesão com aspecto radiográfico radiolúcido, bem circunscrita, localizada próximo a junção amelodentinária de dentes não irrompidos na cavidade bucal. Geralmente, é diagnosticada por meio de radiografias odontológicas de rotina, possui caráter assintomático e rápida progressão após a irrupção. Assim, o objetivo do presente estudo foi revisar e sintetizar os estudos indexados na plataforma PubMed sobre a RIPE. A busca foi realizada por dois revisores independentes e não houve limitação de data de publicação, idioma e desenho de estudo. Artigos pré-selecionados foram triados através da leitura de títulos e resumos e posteriormente pela leitura dos textos na íntegra. A busca inicial resultou em 37 estudos identificados. Após a leitura de títulos e resumos, três foram excluídos por não cumprirem os critérios de elegibilidade. Restaram então, 34 artigos para leitura do texto na íntegra. Desses, 4 foram excluídos, pois os textos completos não foram localizados. Assim, 30 estudos foram incluídos para análise na presente revisão. Os estudos sobre RIPE ainda são escassos e a maioria são relatos de caso. Os fatores etiológicos não são totalmente estabelecidos e parece haver uma maior prevalência em indivíduos do sexo feminino, com maior acometimento em dentes mandibulares permanentes. A maioria das lesões são identificadas na fase de dentição mista por radiografias de rotina e o tratamento depende da extensão e momento diagnóstico quanto à erupção dentária.
Transtorno do Déficit de Atenção e Hiperatividade em pacientes com fenilcetonúria: revisão bibliográfica
Authors: Silva Amanda Cristina da , Davoglio Larissa Maria de Paula , Federisi Alexandre , Aguiar Alisson Lima de , Garcia Ana Laura Folcheti , Dias Claudia Rodrigues Mustafa , Davoglio Gabriela Maria de Paula , Stábile Ithalo de Sousa Bonomi , Garcia Neto José , Abreu Luiza Moura de Almeida , Carvalho Erica Lopes de , Fabro Pâmela Santos , Contrucci Bruno Antunes 
Published: August 2024

Caracterizada pela deficiência da enzima fenilalanina hidrolixase, a fenilcetonúria (PKU) apresenta-se com elevação sérica do aminoácido aromático fenilalanina (Phe) associado a prejuízo em formação de tirosina. Tanto o acúmulo de substrato quanto a falta do produto resultam em sintomas e sinais clínicos, principalmente relacionados ao desenvolvimento neuropsicomotor com atraso global, hipotonia, crises epilépticas quando não controlada de forma adequada. Além disso, nota-se elevada incidência de distúrbios neurocomportamentais em fenilcetonúricos, principalmente relacionados a condições de disfunção no córtex pré-frontal, como é o caso do transtorno do déficit de atenção e hiperatividade. Com finalidade de entendimento melhor sobre essas condições clínicas, realizado revisão bibliográfica da literatura atual para avaliar a associação entre TDAH e fenilcetonúricos, bem como suas incidências, entendimento de suas bases fisiopatológicas, sintomatológicas clínicas, tratamento e impactos gerais. Notou-se importante relação entre ambas, com aumento da prevalência de TDAH em pacientes com PKU. O controle dietético com manutenção dos níveis séricos de Phe em faixa terapêutica foi evidenciado como parte fundamental para melhores desempenhos neurocognitivos bem como redução importante em sintomas desatentos e hiperativos.
Incidência de doenças em bezerras leiteiras e sua correlação com o desempenho produtivo
Authors: Coutinho Juddy de Souza , Nogueira Isadora Alves , Pires Neto Otaviano de Souza , Costa Renê Ferreira , Pires Daniel Ananias de Assis , Santos Leandra Cristina Soares , Santos Jaine Aparecida dos , Manhães Cíntia Aparecida de Almeida , Félix Magna Félix , Moura Marielly Maria Almeida 
Published: August 2024

Objetivou-se avaliar a incidência de doenças em bezerras leiteiras no norte de Minas Gerais e correlacionar a presença de infecções com o desempenho dos animais. O estudo foi de caráter descritivo e transversal, com pesquisa a campo e coleta de dados em propriedades leiteiras do norte de Minas Gerais, realizando avaliação de bezerras de aptidão leiteira de 1 a 180 dias de vida. Obtenção de dados por meio da anotação em planilhas impressas no período de dezembro de 2023 a maio de 2024. Foram registrados das 120 bezerras avaliadas o percentual de tristeza parasitária totalizando (72,50%) animais infectados, seguido por onfalopatias (29,17%), diarreia (19,16%), verminoses (16,67%) e afecções respiratórias (8,33%). E o desempenho produtivo dos animais quanto ao seu ganho médio diário de peso (GMD) em correlação com as doenças, representou animais sadios (516g), afecções respiratórias (481g), diarreia (469g), tristeza parasitária (447g), verminoses (408g) e onfalopatias (374g). Portanto, conclui-se que a doença que apresentou maior incidência foi a tristeza parasitária e sendo as onfalopatias responsável por menor desempenho produtivo.
Analisis Strategi Pelaku Bisnis Perhotelan Dalam Mendukung Pariwisata Kota Manado
Authors: Langi Madeleine P.V , Lagarense Bet El Silisna , Lintong Oktavianus 
Published: August 2024

Pariwisata merupakan salah satu sektor penting dalam pertumbuhan ekonomi pada suatu wilayah. Dampak pariwisata juga begitu besar dalam membantu melestarikan budaya, sejarah maupun tradisi lokal. Pengelolaan pariwisata yang efektif dapat memberikan pengaruh yang positif terhadap pertumbuhan ekonomi serta industri untuk meningkatkan pengembangan pariwisata khususnya Kota Manado. Pengembangan pariwisata memiliki dampak yang cukup signifikan dalam berbagai aspek yang dimulai dari, dampak ekonomi, yang dapat meningkatkan pendapatan masyarakat, dengan meningkatnya lapangan pekerjaan yang tersedia lalu dampak sosial, lewat pengembangan pariwisata yang memberikan kesadaran terhadap warisan sejarah dan budaya dari daerah lokal. Terdapat kendala yang dihadapi dalam pengelolaan bisnis perhotelan seperti, persaingan kualitas dengan harus adanya strategi pemasaran yang kuat dan diferensiasi yang jelas. Lalu perrlu menganalisis mengenai strategi pemasaran yang dilakukan dengan efektif untuk menarik wisatawan. Penelitian ini menggunakan metode penelitian kualitatif, yang bertujuan untuk menganalisis Bisnis Perhotelan Dalam Pengembangan Pariwisata di Kota Manado, dengan menggunakan teknik pengumpulan data berupa wawancara langsung pada pihak manajemen hotel khususnya pada bagian penjualan dan marketing, serta melakukan survey online guna mengetahui promosi-promosi seperti apa yang dilakukan oleh pihak hotel melaui media sosial. Hasil penelitian yang telah di lakukan membuktikan bahwa bisnis perhotelan memiliki pengaruh besar dalam pengembangan sektor pariwisata yang ada di Kota Manado sebab berperan penting dalam menyediakan sarana akomodasi bagi para wisatawan, sehingga dapat memberikan pendapatan pada hotel. Kesimpulan yang dapat ditarik adalah, pada prinsipnya masing-masing dari pihak pengelola Hotel memiliki strategi masing-masing dalam memajukkan masing-masing hotel, namun memiliki standarisasi yang sama, yaitu bagaimana bisa memberikan pelayanan yang terbaik sesuai dengan kemampuan dan fasilitas Hotel. Soal persaingan dan mutu adalah internal masing-masing pengelola.