bluuebunny/crossref_metadata_2025_split huggingface dataset:
The development of pediatric anesthesiology and critical care medicine at the Cincinnati Children's Hospital: an interview with Dr. Theodore Striker
Authors: Ahmed Zulfiqar , Samuels Paul J. , Mai Christine L. , Rodriguez Samuel , Iftikhar Ahmed Raza , Yaster Myron 
Published: May 2015

SummaryDr. Theodore W. ‘Ted’ Striker (1936–), Professor of Anesthesiology and Pediatrics at the University of Cincinnati, has played a pioneering role in the development of pediatric anesthesiology in the United States. As a model educator, clinician, and administrator, he shaped the careers of hundreds of physicians‐in‐training and imbued them with his core values of honesty, integrity, and responsibility.
Evidence‐based Status of Pulsed Radiofrequency Treatment for Patients with Shoulder Pain: A Systematic Review of Randomized Controlled Trials
Authors: Liu An , Zhang Wei , Sun Miao , Ma Chiyuan , Yan Shigui 
Published: May 2015

AbstractPurposeReview the current evidence‐based status of pulsed radiofrequency (PRF) treatment for patients with shoulder pain based on randomized controlled trials (RCTs) to provide a comprehensive analysis and a balanced view of the strengths and weaknesses of this treatment.MethodsPubMed, EMBASE, the Cochrane Library, and ISI Web of Science were searched up to July 2014, using the Boolean operators as follows: shoulder pain OR painful shoulder AND pulsed radiofrequency). All prospective randomized controlled trials of PRF treatment for patients with shoulder pain were retrieved. No limitation of the language or publication year existed in our analysis.ResultsFive of 114 studies that involved PRF treatment met the inclusion criteria of this review article. These studies compared the clinical outcomes of PRF with those of other treatments such as intra‐articular corticosteroid injection and conventional transcutaneous electrical nerve stimulation. All the studies reported improvements in passive range of motion (PROM), visual analog scale (VAS), and Shoulder Pain and Disability Index (SPADI) in PRF treatment that persisted for at least 12 weeks. In addition, no complications were reported in all trials.ConclusionThe use of PRF treatment for patients with shoulder pain was observed to result in good clinical efficacy for at least 12 weeks with no complication reported. However, it is still unclear from the currently available publications whether PRF is superior to other treatment techniques such as intra‐articular corticosteroid and conventional transcutaneous electrical nerve stimulation.
Hyperbaric Oxygen Therapy: A New Treatment for Chronic Pain?
Authors: Sutherland Ainsley M. , Clarke Hance A. , Katz Joel , Katznelson Rita 
Published: May 2015

AbstractBackground and objectiveHyperbaric oxygen therapy (HBOT) is a treatment providing 100% oxygen at a pressure greater than that at sea level. HBOT is becoming increasingly recognized as a potential treatment modality for a broad range of ailments, including chronic pain. In this narrative review, we discuss the current understanding of pathophysiology of nociceptive, inflammatory and neuropathic pain, and the body of animal studies addressing mechanisms by which HBOT may ameliorate these different types of pain. Finally, we review clinical studies suggesting that HBOT may be useful in treating chronic pain syndromes, including chronic headache, fibromyalgia, complex regional pain syndrome, and trigeminal neuralgia.Database and data treatmentA comprehensive search through MEDLINE, EMBASE, Scopus, and Web of Science for studies relating to HBOT and pain was performed using the following keywords: hyperbaric oxygen therapy or hyperbaric oxygen treatment (HBOT), nociceptive pain, inflammatory pain, neuropathic pain, HBOT AND pain, HBOT AND headache, HBOT AND fibromyalgia, HBOT AND complex regional pain syndrome, and HBOT AND trigeminal neuralgia.ResultsTwenty‐five studies examining the role of HBOT in animal models of pain and human clinical trials were found and reviewed for this narrative review.ConclusionsHBOT has been shown to reduce pain using animal models. Early clinical research indicates HBOT may also be useful in modulating human pain; however, further studies are required to determine whether HBOT is a safe and efficacious treatment modality for chronic pain conditions.
FERONIA receptor kinase interacts with S‐adenosylmethionine synthetase and suppresses S‐adenosylmethionine production and ethylene biosynthesis in Arabidopsis
Authors: Mao Dandan , Yu Feng , Li Jian , Van de poel Bram , Tan Dan , Li Jianglin , Liu Yanqionq , Li Xiushang , Dong Mengqiu , Chen Liangbi , Li Dongping , Luan Sheng 
Published: May 2015

AbstractEnvironmental inputs such as stress can modulate plant cell metabolism, but the detailed mechanism remains unclear. We report here that FERONIA (FER), a plasma membrane receptor‐like kinase, may negatively regulate the S‐adenosylmethionine (SAM) synthesis by interacting with two S‐adenosylmethionine synthases (SAM1 and SAM2). SAM participates in ethylene, nicotianamine and polyamine biosynthetic pathways and provides the methyl group for protein and DNA methylation reactions. The Arabidopsis fer mutants contained a higher level of SAM and ethylene in plant tissues and displayed a dwarf phenotype. Such phenotype in the fer mutants was mimicked by over‐expressing the S‐adenosylmethionine synthetase in transgenic plants, whereas sam1/2 double mutant showed an opposite phenotype. We propose that FER receptor kinase, in response to environmental stress and plant hormones such as auxin and BR, interacts with SAM synthases and down‐regulates ethylene biosynthesis.
Prenatal Infection and Autism Spectrum Disorders in Childhood: A Population‐Based Case–Control Study in Taiwan
Authors: Fang Shao‐You , Wang Sabrina , Huang Nicole , Yeh Hsueh‐Han , Chen Chuan‐Yu 
Published: May 2015

AbstractBackgroundInfection in pregnancy has long been linked with negative postnatal development and health. This study aims to assess the association between prenatal infections and autism spectrum disorders (ASDs) across three trimesters and to probe possible sex heterogeneity in such link.MethodA total of 4184 children with incident ASDs and 16 734 matched children were identified from the 2000–2007 National Health Insurance Research Database. For each child, information pertaining to the mother's infection during pregnancy, sociodemographics, and medical history was retrieved from healthcare records. Conditional logistic analyses were carried out to estimate the strength of associations with adjustment for multiple comparisons.ResultPooled analyses demonstrated that having two or more outpatient visits for genital infection [adjusted odds ratio (aOR): 1.34; 95% confidence interval (95% CI) 1.12, 1.60; false discovery rate (FDR) < 0.01] and bacterial infection (aOR: 1.24; 95% CI 1.06, 1.43; FDR < 0.05) in the third trimester were slightly associated with increased risk of ASDs. No statistically significant sex differences were found.ConclusionThe present study contributes updated population‐based evidence about the connection between prenatal infection and ASDs. Potential effect of bacterial and genital tract infections during the third trimester on risk of ASDs warrants further exploration.
Impact of HMG‐CoA reductase inhibitors on the incidence of polyomavirus‐associated nephropathy in renal transplant recipients with human BK polyomavirus viremia
Authors: Gabardi S. , Ramasamy S. , Kim M. , Klasek R. , Carter D. , Mackenzie M.R. , Chandraker A. , Tan C.S. 
Published: May 2015

AbstractBackgroundUp to 20% of renal transplant recipients (RTR) will develop human BK polyomavirus (BKPyV) viremia. BKPyV viremia is a pre‐requisite of polyomavirus‐associated nephropathy (PyVAN). Risk of BKPyV infections increases with immunosuppression. Currently, the only effective therapy against PyVAN is reductions in immunosuppression, but this may increase the risk of rejection. In vitro data have shown that pravastatin dramatically decreased caveolin‐1 expression in human renal proximal tubular epithelial cells (HRPTEC) and suppressed BKPyV infection in these cells. Based on these data, we postulated that statin therapy may prevent the progression of BKPyV viremia to PyVAN.Patients and methodsA multicenter, retrospective study was conducted in adult RTR transplanted between July 2005 and March 2012. All patients with documented BKPyV viremia (viral load >500 copies/mL on 2 consecutive tests) were included. Group I consisted of patients taking a statin before the BKPyV viremia diagnosis (n = 32), and Group II had no statin exposure before or after the BKPyV viremia diagnosis (n = 36). The primary endpoint was the incidence of PyVAN.ResultsDemographic data, transplant characteristics, and the degree of immunosuppression (i.e., induction/maintenance therapies, rejection treatment) were similar between the groups, with the exception of more diabetics in Group I. The incidence of PyVAN was comparable between the 2 groups (Group I = 28.1% vs. Group II = 41.7%; P = 0.312).ConclusionsDespite the proven in vitro effectiveness of pravastatin preventing BKPyV infection in HRPTEC, statins at doses maximized for cholesterol lowering, in RTR with BKPyV viremia, did not prevent progression to PyVAN.
Information Foraging Across the Life Span: Search and Switch in Unknown Patches
Authors: Chin Jessie , Payne Brennan R. , Fu Wai‐Tat , Morrow Daniel G. , Stine‐Morrow Elizabeth A. L. 
Published: May 2015

AbstractIn this study, we used a word search puzzle paradigm to investigate age differences in the rate of information gain (RG; i.e., word gain as a function of time) and the cues used to make patch‐departure decisions in information foraging. The likelihood of patch departure increased as the profitability of the patch decreased generally. Both younger and older adults persisted past the point of optimality as defined by the marginal value theorem (Charnov, 1976), which assumes perfect knowledge of the foraging ecology. Nevertheless, there was evidence that adults were rational in terms of being sensitive to the change in RG for making the patch‐departure decisions. However, given the limitations in cognitive resources and knowledge about the ecology, the estimation of RG may not be accurate. Younger adults were more likely to leave the puzzle as the long‐term RG incrementally decreased, whereas older adults were more likely to leave the puzzle as the local RG decreased. However, older adults with better executive control were more likely to adjust their likelihood of patch‐departure decisions to the long‐term change in RG. Thus, age‐dependent reliance on the long‐term or local change in RG to make patch‐departure decisions might be due to individual differences in executive control.
Canine brain tumours: a model for the human disease?
Authors: Hicks J. , Platt S. , Kent M. , Haley A. 
Published: May 2015

AbstractCanine brain tumours are becoming established as naturally occurring models of disease to advance diagnostic and therapeutic understanding successfully. The size and structure of the dog's brain, histopathology and molecular characteristics of canine brain tumours, as well as the presence of an intact immune system, all support the potential success of this model. The limited success of current therapeutic regimens such as surgery and radiation for dogs with intracranial tumours means that there can be tremendous mutual benefit from collaboration with our human counterparts resulting in the development of new treatments. The similarities and differences between the canine and human diseases are described in this article, emphasizing both the importance and limitations of canines in brain tumour research. Recent clinical veterinary therapeutic trials are also described to demonstrate the areas of research in which canines have already been utilized and to highlight the important potential benefits of translational research to companion dogs.
Attenuation of methylene blue dye during riverbank filtration through sandy aquifers
Authors: Mishra Shrinishtha , Kumar Pradeep 
Published: May 2015

AbstractAlthough several studies have focused on the removal of organics and pathogens during riverbank filtration (RBF), no study has been carried out on the attenuation of dyes during RBF. In the present work, removal of methylene blue (MB) through aquifer materials collected from five RBF sites in India has been investigated. Brunauer Emmet Teller (BET) surface areas of the aquifer materials were 1.2–6.5 m2/g. Adsorption followed the pseudo‐second‐order kinetics and Langmuir isotherm, suggesting monolayer adsorption. Column results showed saturation capacity of 0.467–1.234 mg MB/g for different aquifer materials. Retardation factors for MB were found to be very high ranging from 430 to 987, due to its high hydrophobicity (octanol/water partition coefficient = 5.85). Results showed that BET surface area or the roughness played a very important role in the retardation of MB. Results suggest that the breakthrough of MB in a RBF well in sandy aquifers will take several years.
Molecular phylogeny and the underestimated species diversity of the endemic white‐bellied rat (Rodentia: Muridae:Niviventer) in Southeast Asia and China
Authors: Lu Liang , Ge Deyan , Chesters Douglas , Ho Simon Y. W. , Ma Ying , Li Guichang , Wen Zhixin , Wu Yongjie , Wang Jun , Xia Lin , Liu Jingli , Guo Tianyu , Zhang Xiaolong , Zhu Chaodong , Yang Qisen , Liu Qiyong 
Published: May 2015

The white‐bellied rat,Niviventer, is a genus endemic to Southeast Asia and China. However, the interspecific phylogenetic relationships and species diversity of this genus remain poorly understood. In the present study, single and multi‐locus analyses were performed. Phylogenetic reconstruction on Cytochrome b (512 individuals, including data from Genbank) revealed five major clades with approximately 35 operational taxonomic units (OTUs), a number twice the existing taxonomy. The first clade (N. langbianisspecies group) was the earliest diverged. The second clade (N. fulvescensspecies group) diverged in Southeast Asia, the south and lower altitude regions of the Hengduan Mountains, and Southeast China. The third clade (theN. ehaspecies group) is endemic to high altitudes in Northwest Yunnan and the central region of Himalaya. The fourth clade (theN. andersonispecies group), is mainly confined to alpine regions of the Hengduan Mountains. The fifth clade (N. confucianusspecies group) is mainly distributed in the north and higher altitude regions of eastern Himalaya, the Hengduan Mountains and Taiwan, with the complex also invading central and northern China. Results from the combined dataset of four genes (Cytochrome b, Cytochrome oxidase subunit I, the D‐loop sequence of the mitochondrial genome and the first exon of the nuclear interphotoreceptor retinoid binding protein) for 82 representative individuals from China generally coincide with the result of the single gene, with 12OTUs identified. These results provide a preliminary framework for the existing classification of this highly diversified genus. The divergence time ofNiviventerbased on the four gene topology was dated to the late Miocene ~6.41 Ma. Significant differences were detected in the general body form changes among these units based on voucher specimens. Moreover, geometric morphometric analysis of the cranium shape of voucher specimens indicated significant differences among five major species groups. Shape divergence of the cranium among severalOTUs within theN. confucinauscomplex is also significant. Our results provide further evidence for rapid and highly underestimated diversification ofNiviventerboth in genetics and morphology.
Low haemoglobin concentration in Tibetan males is associated with greater high‐altitude exercise capacity
Authors: Simonson T. S. , Wei G. , Wagner H. E. , Wuren T. , Qin G. , Yan M. , Wagner P. D. , Ge R. L. 
Published: May 2015

Key points
We hypothesized that sea‐level range haemoglobin concentration ([Hb]) at altitude, previously linked with adaptive genetic factors in Tibetans, would be associated with greater exercise capacity, explained by changes in steps of the oxygen transport system in this population.
In 21 Tibetan and 9 Han Chinese males resident at 4200–4300 m, we measured [Hb], ventilation, volumes of O2 and CO2 utilized at peak exercise ( and ), heart rate, cardiac output and arterial blood gas variables at peak exercise on a cycle ergometer and determined oxygen (O2) diffusion capacity in lung and muscle.
Tibetans with low [Hb] exhibit greater peak kg–1, which was explained mostly by variation in cardiac output, ventilation and O2 diffusional conductances in muscle.
These results suggest that polycythaemia may be an excessive response to low at altitude.
AbstractTibetans living at high altitude have adapted genetically such that many display a low erythropoietic response, resulting in near sea‐level haemoglobin (Hb) concentration. We hypothesized that absence of the erythropoietic response would be associated with greater exercise capacity compared to those with high [Hb] as a result of beneficial changes in oxygen transport. We measured, in 21 Tibetan males with [Hb] ranging from 15.2 g dl−1 to 22.9 g dl−1 (9.4 mmol l−1 to 14.2 mmol l−1), [Hb], ventilation, volumes of O2 and CO2 utilized at peak exercise ( and ), heart rate, cardiac output and arterial blood gas variables at peak exercise on a cycle ergometer at ∼4200 m. Lung and muscle O2 diffusional conductances were computed from these measurements. [Hb] was related (negatively) to kg–1 (r = −0.45, P< 0.05), cardiac output kg–1 (QT kg–1, r = −0.54, P < 0.02), and O2 diffusion capacity in muscle (DM kg–1, r = −0.44, P<0.05), but was unrelated to ventilation, arterial partial pressure of O2 () or pulmonary diffusing capacity. Using multiple linear regression, variance in peak kg–1 was primarily attributed to QT, DM, and (R2 = 0.88). However, variance in pulmonary gas exchange played essentially no role in determining peak . These results (1) show higher exercise capacity in Tibetans without the erythropoietic response, supported mostly by cardiac and muscle O2 transport capacity and ventilation rather than pulmonary adaptations, and (2) support the emerging hypothesis that the polycythaemia of altitude, normally a beneficial response to low cellular , may become maladaptive if excessively elevated under chronic hypoxia. The cause and effect relationships among [Hb], QT, DM, and remain to be elucidated.
Impact of Ciprofloxacin and Clindamycin Administration on Gram-Negative Bacteria Isolated from Healthy Volunteers and Characterization of the Resistance Genes They Harbor
Authors: Card Roderick M. , Mafura Muriel , Hunt Theresa , Kirchner Miranda , Weile Jan , Rashid Mamun-Ur , Weintraub Andrej , Nord Carl Erik , Anjum Muna F. 
Published: May 2015

ABSTRACT

The aim of this study was to assess the impact of ciprofloxacin, clindamycin, and placebo administration on culturable Gram-negative isolates and the antibiotic resistance genes they harbor. Saliva and fecal samples were collected from healthy human volunteers before and at intervals, up to 1 year after antibiotic administration. Samples were plated on selective and nonselective media to monitor changes in different colony types or bacterial species. Following ciprofloxacin administration, there was a decrease of
Escherichia coli
in feces and after clindamycin administration a decrease of
Bacteroides
in feces and
Leptotrichia
in saliva, which all returned to pretreatment levels within 1 to 4 months. Ciprofloxacin administration also resulted in an increase in ciprofloxacin-resistant
Veillonella
in saliva, which persisted for 12 months. Additionally, 949 aerobic and anaerobic isolates purified from ciprofloxacin- and clindamycin-containing plates were screened for the presence of resistance genes. Resistance gene carriage was widespread in isolates from all three treatment groups, and no association was observed between genes and antibiotic administration. Although the anaerobic component of the microbiota was not a major reservoir of aerobe-associated antimicrobial resistance (AMR) genes, we detected the sulfonamide resistance gene
sul2
in anaerobic isolates. The longitudinal nature of the study allowed identification of distinct
Escherichia coli
clones harboring multiple resistance genes, including one carrying an extended-spectrum β-lactamase
bla
CTX-M
group 9 gene, which persisted in the gut for up to 4 months. This study provided insight into the effects of antibiotic administration on healthy microbiota and the diversity of resistance genes harbored therein.
Gametocyte Clearance Kinetics Determined by Quantitative Magnetic Fractionation in Melanesian Children with Uncomplicated Malaria Treated with Artemisinin Combination Therapy
Authors: Karl Stephan , Laman Moses , Moore Brioni R. , Benjamin John , Koleala Tamarah , Ibam Clemencia , Kasian Bernadine , Siba Peter M. , Waltmann Andreea , Mueller Ivo , Woodward Robert C. , St. Pierre Timothy G. , Davis Timothy M. E. 
Published: May 2015

ABSTRACT

Quantitative magnetic fractionation and a published mathematical model were used to characterize between-treatment differences in gametocyte density and prevalence in 70 Papua New Guinean children with uncomplicated
Plasmodium falciparum
and/or
Plasmodium vivax
malaria randomized to one of two artemisinin combination therapies (artemether-lumefantrine or artemisinin-naphthoquine) in an intervention trial. There was an initial rise in peripheral
P. falciparum
gametocyte density with both treatments, but it was more pronounced in the artemisinin-naphthoquine group. Model-derived estimates of the median pretreatment sequestered gametocyte population were 21/μl for artemether-lumefantrine and 61/μl for artemisinin-naphthoquine (
P
< 0.001). The median time for
P. falciparum
gametocyte density to fall to <2.5/μl (below which transmission becomes unlikely) was 16 days in the artemether-lumefantrine group and 20 days in artemisinin-naphthoquine group (
P
< 0.001). Gametocyte prevalence modeling suggested that artemisinin-naphthoquine-treated children became gametocytemic faster (median, 2.2 days) than artemether-lumefantrine-treated children (median, 5.3 days;
P
< 0.001) and had a longer median
P. falciparum
gametocyte carriage time per individual (20 versus 13 days;
P
< 0.001). Clearance of
P. vivax
gametocytes was rapid (within 3 days) in both groups; however, consistent with the reappearance of asexual forms in the main trial, nearly 40% of children in the artemether-lumefantrine group developed
P. vivax
gametocytemia between days 28 and 42 compared with 3% of children in the artemisinin-naphthoquine group. These data suggest that artemisinin is less active than artemether against sequestered gametocytes. Greater initial gametocyte release after artemisinin-naphthoquine increases the period of potential
P. falciparum
transmission by 4 days relative to artemether-lumefantrine, but the longer elimination half-life of naphthoquine than of lumefantrine suppresses
P. vivax
recurrence and consequent gametocytemia.
Retrograde Trafficking Inhibitor of Shiga Toxins Reduces Morbidity and Mortality of Mice Infected with Enterohemorrhagic Escherichia coli
Authors: Secher T. , Shima A. , Hinsinger K. , Cintrat J. C. , Johannes L. , Barbier J. , Gillet D. , Oswald E. 
Published: May 2015

ABSTRACT

The most deadly outbreak of
Escherichia coli
O104:H4 occurred in Europe in 2011. Here, we evaluated the effects of the retrograde trafficking inhibitor Retro-2
cycl
in a murine model of
E. coli
O104:H4 infection. Systemic treatment with Retro-2
cycl
significantly reduced body weight loss and improved clinical scores and survival rates for O104:H4-infected mice. The present data established that Retro-2
cycl
contributes to the protection of mice against O104:H4 infection and may represent a novel approach to limit Shiga toxin-producing
Escherichia coli
(STEC)-induced toxicity.