bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced skin regeneration and therapeutic delivery using novel diamond‐augmented zinc oxide
Authors: Zhang Xinge Diana , Teng Claudia , Bai Xuefei , Teng Joyce , Chilukuri Suneel , Lewis Amy , Gold Michael H. 
Published: July 2024

AbstractBackgroundRecent advancements in dermatological therapeutics have highlighted the need for treatments that enhance skin regeneration and healing. Diamond‐Augmented Zinc Oxide (ND‐ZnO) technology combines zinc oxide with diamond particles in a unique core‐shell structure, offering a multifaceted approach to overall skin health.AimsThis study evaluates the efficacy of ND‐ZnO in promoting human dermal fibroblast migration and growth, enhancing total collagen synthesis, and improving transdermal delivery of active ingredients as a daily comprehensive skin regeneration topical therapy.Patients/MethodsIn vitro assays assessed wound healing, collagen production, and skin absorption. Human Dermal Fibroblasts (HDFs) were used in scratch wound assays. Collagen synthesis was quantified using enzyme‐linked immunosorbent assays (ELISA). Permeation tests were performed on reconstructed human epidermal tissues to evaluate niacinamide absorption. Clinical case studies validated ND‐ZnO efficacy in post‐CO₂ laser treatments and Actinic Keratosis removal recovery.ResultsND‐ZnO increased HDF migration by 198% compared to controls. Collagen synthesis assays showed a 71.3% restoration of collagen production in aged HDFs. Skin permeation studies revealed a 203% increase in niacinamide skin absorption with ND‐ZnO. Clinical case studies demonstrated faster and more effective healing post‐ablative CO₂ laser and significant improvements in Actinic Keratosis recovery.ConclusionsND‐ZnO technology enhances wound healing, collagen synthesis, and active ingredient delivery, offering substantial benefits for daily skin regeneration and other dermatological applications. This innovative approach holds promise for advancing dermatological therapeutics, providing comprehensive skin care solutions that address both protective and regenerative needs.
The effects of the COVID‐19 pandemic on urban and rural hospital profitability
Authors: McFadyen Laura , Gurzenda Susie , Pink George , Malone Tyler , Reiter Kristin 
Published: July 2024

AbstractIntroductionThere are long‐standing differences in profitability between rural and urban hospitals. Prior to the COVID‐19 Public Health Emergency (PHE), rural hospital profitability was decreasing, while urban hospital profitability was increasing. During the PHE, the Federal Government provided billions of dollars of support to hospitals. Given the prepandemic differences in trends in profitability, it is likely that the PHE funding had different effects on rural hospitals and urban hospitals.MethodsThis study uses 2015–2023 Medicare cost report data from acute‐care hospitals to assess the impact of COVID‐19 PHE funding on hospital profitability. We employ descriptive Kruskal–Wallis and chi‐square tests and an interrupted time series analysis to evaluate the effect of PHE funding on operating margins for a stratified sample of rural prospective payment system (PPS), urban PPS, and critical access hospitals (CAHs).ResultsWe found that the PHE funding was associated with significant increases in operating margins, with rural PPS hospitals experiencing similar increases compared to urban PPS hospitals, and CAHs surpassing both rural and urban PPS hospitals in their margin values. However, if PHE funding had not been provided, our evidence suggests operating margins for all hospitals in 2022–2023 would have been below prepandemic levels.DiscussionThis preliminary analysis portrays the importance of the PHE government funding in supporting hospitals during the pandemic, and shows declining profitability trends without the funds. Rural PPS hospitals fare the worst suggesting continued need for financial support if the trend continues.
Collocation in the Mind: Investigating Collocational Priming in Second Language Speakers of Italian
Authors: Fioravanti Irene , Siyanova‐Chanturia Anna , Lenci Alessandro 
Published: July 2024

AbstractCollocational priming is a priming effect induced by collocationally related words; it has been taken to explain the cognitive reality of collocation. Collocational priming has largely been observed in first language (L1) speakers, whereas work on the representation of collocation in a second language (L2) is still limited. In the present study, we sought to investigate this phenomenon in L1 and L2 speakers of Italian. We used a lexical decision task to explore collocational priming in verb–noun and noun–adjective collocations differing in frequency and collocational strength. Both L1 and L2 speakers were found sensitive to the frequency of collocations. Importantly, exposure to L2 Italian was found to play a role. The results suggest that collocational priming occurs both in L1 and L2 speakers, and that the mechanisms associated with collocation processing and representation in L1 and L2 speakers may be comparable.
Realising Person‐Centredness: Transitioning to a Clustered Domestic Model of Aged Residential Care for People With and Without Dementia
Authors: Shannon Kay , Cook Catherine , Neville Stephen 
Published: July 2024

ABSTRACTIntroductionMany older people who cannot live independently live in aged residential care facilities to obtain support with social and healthcare needs. Despite old age being a precious time for people to live well, many facility residents have limited access to activities that promote their well‐being and connectedness. In New Zealand, one provider of aged residential care developed a village inspired by de Hogeweyk in the Netherlands, where resident engagement in valued activities supports continuing lifelong identities.MethodsThe study aimed to explain the transition from a traditional Aged Residential Care facility to a clustered domestic model of care. A critical realist theoretical perspective underpinned case study research. Data comprised transcripts of interviews with key informants, facility staff, residents and their families, records of observation of residents' daily lives, organisational documents, photographs and the first author's study journal.ResultsThe intersection of philosophical workplace change to support delivery of person‐centred care and a change in the physical environment enabled realisation of the organisational vision of residents living normal lives.ConclusionPolicy makers and practitioners must be aware that while a domestic‐scale environment provides cues to normal living, staff who know residents and what is important to them enable participation in community and valued activities.Implications for PracticeInnovative living arrangements are a synthesis of philosophical aspirations, architectural and design vision, dedicated leadership and committed teamwork.
Is teasing meant to be mean or nice? Retrospective reports of adolescent social experiences and teasing attitudes
Authors: Andrews Naomi C. Z. , Pakkal Oya , Dawes Molly 
Published: July 2024

AbstractPeer teasing has contradictory conceptualizations, including teasing that is playful, and teasing that is akin to bullying. In addition to individuals potentially having different conceptualizations of teasing, and despite the inherently social nature of teasing, little is known about the social correlates of teasing attitudes. The current study aimed to examine multifaceted teasing attitudes (i.e., aggressive, affectionate, or romantic interest teasing), and to assess how past social experiences (victimization, popularity, social satisfaction/self‐concept) relate to teasing attitudes. Young adults (N = 437, 17–25 years old, 65% female) reported on multifaceted teasing attitudes on a Teasing Attitudes Scale developed for this study. Participants also reported retrospectively on adolescent social experiences. Findings validated the Teasing Attitudes Scale, showing that young adults have distinct attitudes toward teasing as aggressive, affectionate, and indicating romantic interest. Participants who reported victimization by bullying, lower popularity (girls only), social satisfaction, and social self‐concept were more likely to view teasing as aggressive. Participants who had been victims of non‐bullying aggression viewed teasing as affectionate, and those with high social satisfaction and self‐concept viewed teasing as for romantic interest purposes. Implications for understanding the complexities of teasing and its associations with individual attitudes and adolescent social experiences will be discussed.
Melanoma classification using generative adversarial network and proximal policy optimization
Authors: Ju Xiangui , Lin Chi‐Ho , Lee Suan , Wei Sizheng 
Published: July 2024

AbstractIn oncology, melanoma is a serious concern, often arising from DNA changes caused mainly by ultraviolet radiation. This cancer is known for its aggressive growth, highlighting the necessity of early detection. Our research introduces a novel deep learning framework for melanoma classification, trained and validated using the extensive SIIM‐ISIC Melanoma Classification Challenge‐ISIC‐2020 dataset. The framework features three dilated convolution layers that extract critical feature vectors for classification. A key aspect of our model is incorporating the Off‐policy Proximal Policy Optimization (Off‐policy PPO) algorithm, which effectively handles data imbalance in the training set by rewarding the accurate classification of underrepresented samples. In this framework, the model is visualized as an agent making a series of decisions, where each sample represents a distinct state. Additionally, a Generative Adversarial Network (GAN) augments training data to improve generalizability, paired with a new regularization technique to stabilize GAN training and prevent mode collapse. The model achieved an F‐measure of 91.836% and a geometric mean of 91.920%, surpassing existing models and demonstrating the model's practical utility in clinical environments. These results demonstrate its potential in enhancing early melanoma detection and informing more accurate treatment approaches, significantly advancing in combating this aggressive cancer.
Salmon lice biology, environmental factors, and smolt behaviour with implications for the Norwegian salmon farming management system: A critical review
Authors: van Nes Solveig , Imsland Albert Kjartan Dagbjartarson , Jones Simon R. M. 
Published: July 2024

AbstractIn 2017, a new regulatory management system, the traffic light system (TLS), was implemented to estimate the effects of salmon lice from Norwegian salmon aquaculture on marine survival of wild Atlantic salmon and forms the basis of aquaculture capacity regulation. The TLS relies on observational data and a set of models to estimate the risk for negative impact on wild salmon populations. This review of the literature that forms the basis for the TLS as well as other relevant studies is presented in the context of the currently practiced TLS and suggestions are made for immediate and long‐term improvements. The main findings of this review are that: (1) assumed timing and duration of smolt migration contribute to unreliable observational and modelled data and overestimates of infection pressure; (2) production of lice larvae from farmed salmon is overestimated; (3) TLS model systems rely on or are calibrated by the same potentially flawed data; (4) lice‐associated mortality in wild salmon smolts may be overestimated; and (5) lice infection levels on farms are not associated with measurable effects on wild salmon. Recommendations to improve the accuracy and reliability of the TLS, and hence its environmental efficiency include the more complete use of available biological and physical environmental variables, adjusting the time period that observational data are registered and modelled data are integrated, adjusting the interpretation of data including recognition of uncertainty in model outcomes, and use of more realistic assumptions concerning lice‐induced mortality thresholds.
Mapping Queer Berlin: The potential of virtual reality pedagogy for the language classroom
Authors: DeSocio Domenic 
Published: July 2024

AbstractImmersive virtual reality (iVR) is a novel form of computer technology that promises to transform not only the delivery of language and cultural instruction but also how students produce language. The existing, yet limited, scholarship on the applications of iVR in the language classroom suggests affective and cultural benefits (e.g., increased student motivation and enthusiasm and bringing inaccessible locations and cultures to students) and a positive impact on vocabulary acquisition and speaking proficiencies, but evidence of iVR's effect on listening comprehension, reading, writing, and grammar instruction as well as higher‐level cognition remains scarce and inconclusive. The project presented in this article, “Mapping Queer Berlin,” targets this scholarly gap by investigating how iVR can improve students’ reading and listening proficiencies and promote advanced research and communication skills. The explanation of the project design and the learning process and outcomes aims to guide instructors on how to integrate iVR into their classrooms, including its technological constraints and pedagogical pitfalls. Drawing on the instructor's and students’ reflections, the article concludes that iVR is currently not mature enough to facilitate significant improvements in students’ language proficiencies beyond an elementary level but shows potential for transforming language curricula with future developments.
PERFORMANCE OF AERATED FLOATING AQUATIC PLANT SYSTEM IN WASTEWATER TREATMENT
Authors: Mohd Said Mohd Ismid , Lakshamanan Seethadevi 
Published: July 2024

A simple lab-scale experiment was conducted to study the performance of aerated and non-aerated water hyacinth systems in treating domestic wastewater, The aerated water hyacinth = system showed higher removalÂ efficiencies than the non-aerated water hyacinth. system. This may be due to aeration induced mixingofwater which allow a greater portion of the wastewater to contact the root zone of ihe plant, arid also increase in microbial activities.
Constitución Y Realidad: Un Problema Capital
Authors: Ferreyra Raúl Gustavo 
Published: July 2024

La Constitución es un objeto complejo que se encuentra en el mundo y que posee cuatro piezas: composición, entorno, mecanismos y estructura. Al tratarse de un instrumento eminentemente normativo presenta una suerte de doble rostro: los problemas relacionados con la existencia de las reglas y los problemas vinculados con la eficacia de las mismas. La naturaleza y alcance de esos problemas, es decir, entre la normatividad y la facticidad de la Constitución ya fueron alertados desde fines del siglo XVIII, con menciones en el siglo anterior. Los estudios se mantuvieron desde entonces y hasta la actualidad y son una preocupación constante de la teoría constitucional, universal o particular. Por tales razones, la fuerza normativa de la Constitución constituye una afirmación elemental, en tanto todas las realizaciones antinormativas llevadas a cabo, en especial, por los servidores públicos, deberían carecer de existencia. Afirmar, pues, la fuerza normativa de la Constitución significa que hay un Derecho positivo de la Constitución que ha sido creado para ser cumplido y una conciencia de una ciudadanía que desea y aspirar a vivir y coexistir con base en reglas de Derecho.
Data Privacy Preserving for Centralized Robotic Fault Diagnosis With Modified Dataset Distillation
Authors: Wang Tao , Huang Yu , Liu Ying , Chen Chong 
Published: July 2024

Abstract
Industrial robots generate monitoring data rich in sensitive information, often making enterprises reluctant to share, which impedes the use of data in fault diagnosis modeling. Dataset distillation (DD) is an effective approach to condense large dataset into smaller, synthesized forms, focusing solely on fault-related features, which facilitates secure and efficient data transfer for diagnostic purposes. However, the challenge of achieving satisfactory fault diagnosis accuracy with distilled data stems from the computational complexity in data distillation process. To address this problem, this article proposes a modified KernelWarehouse (MKW) network-based DD method to achieve accurate fault diagnosis with the distilled dataset. In this algorithm, DD first generates distilled training and testing dataset, followed by the training of an MKW-based network based on these distilled datasets. Specifically, MKW reduces network complexity through the division of static kernels into disjoint kernel cells, which are then computed as linear mixtures from a shared warehouse. An experimental study based on the real-world robotic dataset reveals the effectiveness of the proposed approach. The experimental results indicate that the proposed method can achieve a fault diagnosis accuracy of 86.3% when only trained with distilled data.
Associations of Cognitively Active Versus Passive Sedentary Behaviors and Cognition in Older Adults
Authors: Wingood Mariana , Gell Nancy M. , Rosenberg Dori E. , Stoddard Gregory J. , Bouldin Erin D. 
Published: July 2024

Background: Cognitively stimulating sedentary behavior (SB) may positively impact cognition. This study aimed to (1) describe participation across types of SB among older adults with and without cognitive impairment and (2) examine how baseline SB participation impacts cognition, longitudinally. Methods: We used National Health and Aging Trends Study data from rounds 6 to 11 for cross-sectional and longitudinal analyses. Participants were 2244 community-dwelling older adults who were selected for the SB module in round 6. The SBs were categorized as active (eg, hobbies) and passive (eg, television). Participants were also categorized as having intact or impaired orientation, memory, and executive function based on tests of orientation, recall, and the clock-drawing test. We calculated descriptive statistics characterizing SB by cognitive status. Aim 2 involved competing risks proportional hazard models of participants with intact cognition (n = 1574) to identify associations between baseline SB and changes in cognition, moves to institutional care, and death over 6 years. Results: Participants (40% ≥ 80 years, 55% female, 77% White non-Hispanic) averaged 8.75 (SD = 4.42) hours of daily SB, including 4.05 (SD = 2.32) hours of passive SB and 4.75 (SD = 3.13) hours of active SB. Active SB >3 hours per day was associated with a lower risk of impaired orientation (subdistribution hazard models = 0.60; P = .048) and memory (subdistribution hazard models = 0.62; P = .02). Baseline participation in passive SB did not impact the risk of having a change in cognition during rounds 7 to 11. Conclusion: Cognitive decline was lower among older adults who participated in more active SB. Thus, type of SB should be considered in examining the impact on cognition.
Mapping the functional B-cell epitopes of
Shigella
invasion plasmid antigen D (IpaD)
Authors: Li Siqi , Zhang Weiping 
Published: July 2024

ABSTRACT

Shigella
bacteria utilize the type III secretion system (T3SS) to invade host cells and establish local infection. Invasion plasmid antigen D (IpaD), a component of
Shigella
T3SS, has garnered extensive interest as a vaccine target, primarily due to its pivotal role in the
Shigella
invasion, immunogenic property, and a high degree of conservation across
Shigella
species and serotypes. Currently, we are developing an epitope- and structure-based multivalent vaccine against shigellosis and require functional epitope antigens of key
Shigella
virulence determinants including IpaD. However, individual IpaD B-cell epitopes, their contributions to the overall immunogenicity, and functional activities attributing to bacteria invasion have not been fully characterized. In this study, we predicted continuous B-cell epitopes
in silico
and fused each epitope to a carrier protein. Then, we immunized mice intramuscularly with each epitope fusion protein, examined the IpaD-specific antibody responses, and measured antibodies from each epitope fusion for the activity against
Shigella
invasion
in vitro
. Data showed that all epitope fusion proteins induced similar levels of anti-IpaD IgG antibodies in mice, and differences were noted for antibody inhibition activity against
Shigella
invasion. IpaD epitope 1 (SPGGNDGNSV), IpaD epitope 2 (LGGNGEVVLDNA), and IpaD epitope 5 (SPNNTNGSSTET) induced antibodies significantly better in inhibiting invasion from
Shigella flexneri
2a, and epitopes 1 and 5 elicited antibodies more effectively at preventing invasion of
Shigella sonnei
. These results suggest that IpaD epitopes 1 and 5 can be the IpaD representative antigens for epitope-based polyvalent protein construction and protein-based cross-protective
Shigella
vaccine development.

IMPORTANCE

Shigella
is a leading cause of diarrhea in children younger than 5 years in developing countries (children’s diarrhea) and continues to be a major threat to public health. No licensed vaccines are currently available against the heterogeneous
Shigella
species and serotype strains. Aiming to develop a cross-protective multivalent vaccine against shigellosis and dysentery, we applied novel multiepitope fusion antigen (MEFA) technology to construct a broadly immunogenic polyvalent protein antigen, by presenting functional epitopes of multiple
Shigella
virulence determinants on a backbone protein. The functional IpaD epitopes identified from this study will essentially allow us to construct an optimal polyvalent
Shigella
immunogen, leading to the development of a cross-protective vaccine against shigellosis (and dysentery) and the improvement of global health. In addition, identifying functional epitopes from heterogeneous virulence determinants and using them as antigenic representatives for the development of cross-protective multivalent vaccines can be applied generally in vaccine development.
Detection of a parvovirus and a beak and feather disease virus genome sequence from rose-ringed parakeet (
Psittacula krameri
)
Authors: Sarker Subir , Talukder Saranika 
Published: July 2024

ABSTRACT

This study reports a genome of psittaciform chaphamaparvovirus 4 (PsChPV-4) and a beak and feather disease virus (BFDV) detected in fecal materials of rose-ringed parakeet. The genomes of PsChPV-4 and BFDV were 4,304 and 2,009 bp long, respectively, and both genomes possessed a genomic structure consistent with their respective genera.
Annotated draft genome sequences of
Mucor flavus
KT1a and
Helicostylum pulchrum
KT1b strains isolated from dry-aged beef surface
Authors: Hosono Misa , Torimaru Midori , Fukuda Kenji , Mikami Nana , Toyotome Takahito 
Published: July 2024

ABSTRACT

Mucor flavus
KT1a and
Helicostylum pulchrum
KT1b were isolated and identified in our earlier study as the two dominant fungal species on dry-aged beef. In this study, we report their genome sequences and annotations.
Genomic sequencing of 10 spore-forming
Bacilli
strains isolated from zoo-dwelling mice
Authors: Hashuel Rachel , Gutman Eran , Litvak Yael 
Published: July 2024

ABSTRACT

We present the genomic sequences of 10 spore-forming bacteria from the
Bacillaceae
family isolated from fecal samples of mice residing in the Tisch Family Biblical Zoo, Jerusalem. These isolates suggest Bacillus bacteria are a native component of rodent gut flora, facilitating further research into gut colonization and microbiome diversity.