bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infantile Epileptic Spasms Syndrome in an Infant with PHACTR1 Mutation Triggered by Whole-Cell-Pertussis Vaccine: A Case Report with Review of Literature
Authors: Sharma Sreejana , Khound Murchana , Das Bipul Kumar , Kaushik Jaya Shankar 
Published: February 2025

Abstract

Background:
Early-onset infantile epileptic spasm syndrome is a known feature of phosphatase and actin regulator 1 (PHACTR1) gene mutation. However, its association with whole-cell pertussis vaccination is unknown.

Clinical Description:
A 1-year-old child presented with history of recurrent seizures for the past 8 months, having onset within a few hours after third dose of pentavalent vaccination containing whole-cell pertussis vaccine. There was associated developmental delay. Examination revealed generalized hypotonia with preserved reflexes.

Management and Outcome:
Routine blood investigations were largely normal. Electroencephalography showed classical hypsarrhythmia, while magnetic resonance imaging of the brain was unremarkable. Whole exome sequencing showed c.1499T>C heterozygous mutation in exon 12 of the PHACTR1 gene. The infant was treated with prednisolone, followed by vigabatrin, resulting in seizure-free state.

Conclusion:
Genetic analysis is advisable for infants with epileptic infantile spasms which are triggered by vaccination. PHACTR1 gene mutation could be one of the genetic variations, predisposing infants to vaccine-triggered seizures.
Superior Mesenteric Artery Syndrome with Anorexia Nervosa: A Rare Case of Postprandial Vomiting in an Adolescent
Authors: Reshmi Y. S. , Basker Mona M. , Ebenezer Ananthi 
Published: February 2025

Abstract

Background:
Superior mesenteric artery (SMA) syndrome is an underdiagnosed complication of acute, severe weight loss, usually seen among adolescents. Reduction of mesenteric fat causes SMA to compress the duodenum against the abdominal aorta. It is a known complication of restrictive eating disorder like anorexia nervosa (AN).

Clinical Description:
An 11-years-8-month-old girl presented with vomiting after feeds, and avoidance of food over 1.5 years, with weight loss, fatigue, and excessive sleepiness over the past 5 months. She attained menarche 10 months ago, preceded by an apparent spurt in height, but developed amenorrhea following two cycles. On examination, she was tall, relative to her weight with a low body mass index (BMI) of 12.3 kg/m2, Tanner stage 3. She showed exaggerated orthostatic pulse and blood pressure changes. Her general physical and systemic examinations were otherwise normal.

Management and Outcome:
Routine blood investigations were unremarkable. Abdominal X-ray and barium swallow were normal. Investigations for common chronic infections were negative, and she fulfilled the criteria for AN binge-purge type. Further, ultrasound abdomen showed reduction in the aortomesenteric distance and upstream dilation of the second and third part of the duodenum, suggestive of SMA syndrome, confirmed by computed tomography abdomen. Nutritional rehabilitation was done initially via nasogastric tube, later through nasojejunostomy, with high-calorie diet, gradually being shifted to oral. With multidisciplinary team management, the child recovered, with weight gain of 2.67 kg over 3 weeks.

Conclusion:
Pediatricians need to keep in mind SMA syndrome as a rare cause of intractable vomiting and food aversion, especially during growth spurt with drastic fall in BMI due to eating disorders. Nutritional rehabilitation and counseling are enough to reverse all symptoms.
A Modified Clip-and-drop Technique Using LigaSure Device in the Management of Multifocal Necrotizing Enterocolitis
Authors: Bawazir Osama A. , Baajlan Ohoud Mohammad 
Published: February 2025

Introduction:
Despite the acknowledgment in the previous decades and all the extensive studies of necrotizing enterocolitis (NEC), the controversy regarding this problem is still on-going and unsolved. It is a common gastrointestinal life-threatening emergency that occurs primarily in 90% of the preterm infants. Surgery is usually indicated in approximately 27%–52% of infants with NEC.

Case 1:
Full-term, birth weight of 3.2 kg. At 14 days old, he developed pneumoperitonea, at exploratory laparotomy, all the necrotic segments were sealed and divided using 5 mm LigaSure device. All the edges of the resected bowel were sealed and return in the abdominal cavity. At the second look surgery, assurance of bowel viability was established. The sealed bowel segments were completely closed.

Case 2:
A 33-week-old gestational age, of 2000 g. was operated upon at the age of 14 days for developing pneumoperitoneum. At exploration, there was evidence of extensive NEC involving the entire small intestine reaching to the cecum with multiple necrotic and perforated areas was found. All the segments of necrosis were resected using 5-mm LigaSure device. The small areas of perforation were patched. At second-look surgery, all the sealed bowel segments and the areas of patch perforation were viable, with good sealing without any complications. Anastomosis of the multiple resected segments was done with “Shish-Kebab” technique.

Discussion:
Multifocal NEC is a challenging spectrum of the disease for pediatric surgeon, as there are various surgical options in their management. LigaSure is an electrothermal sealing system that combines dissecting and reconstructing abilities in a single instrument, without the need to reload with each use. Thus, it reduces the cost as well as shorten the operative time as mentioned in the previous studies. In addition, it has the advantage over clips as they do not leave any metallics in the body, furthermore, the risk to damage the surrounding structures is less due to minimal thermal spread so limited injury, and it considers easy to use.

Conclusion:
LigaSure device is an effective and safe method in sealing small bowel in sick neonates with multifocal NEC if applied with single application and with minimal manipulation of the bowel and most importantly minimizing the operative time.
Comparison of Noncontact Forehead Infrared Thermometer with Digital Axillary Thermometer in Newborns in Low- and Middle-income Countries
Authors: Das Sreetama , Pal Somnath , Ghosh Moumita 
Published: February 2025

Background:
Noncontact forehead infrared thermometry can be a rapid and developmentally supportive measurement of temperature in newborns. This study compared forehead infrared temperature with digital axillary temperature in newborns in the setting of a developing country.

Materials and Methods:
An agreement study was conducted from March 2024 to May 2024 in a tertiary neonatal unit of India. A maximum acceptable limit of ±0.5° between 2 methods was chosen. Agreement between both readings was assessed by Bland–Altman analysis. A multiple linear regression model was built to predict factors affecting the difference between both methods and validated using bootstrap samples with replacement. Revised Premature Infant Pain Profile (PIPP) was used for documenting pain attributed by each method and the difference was assessed using paired t-test.

Results:
Three hundred temperature records were collected from 181 infants. Mean difference between 2 methods was −0.004°C signifying the absence of systematic bias. Upper and lower limit of agreements was 0.61°C and −0.62°C. There was a proportional bias with forehead temperature underestimating axillary temperature above 37.5°C, which increased further while using warmer. Infrared thermometer showed good accuracy in detecting hyperthermia (area under curve 0.964, P < 0.001). Revised PIPP score was higher in digital axillary thermometry (P < 0.05).

Conclusion:
Forehead infrared temperatures were found to be distributed within ±0.6°C of the axillary temperatures. It can be used as a screening tool for hyperthermia in newborns in developing countries.
The Correlation between the Axilla and Different Parts of the Body Skin Temperature in Premature Infants Hospitalized
Authors: Shoghi Mahnaz , Rahimi Ashraf , Kheradmand Motahareh 
Published: February 2025

Background:
Continuous temperature monitoring using a skin sensor is the standard method for temperature measurement in neonatal intensive care units (NICUs). This study aimed to determine the correlation between left axillary temperature and five body sites, including the liver, left flank, area between the xiphoid and umbilicus, right flank, and back, in premature infants hospitalized in the NICU.

Materials and Methods:
This cross-sectional study included 185 premature infants placed under radiant warmer in the NICU. The skin temperature at five body sites, including the liver, left flank, between the xiphoid and umbilicus region, right flank, and back, was compared with the results of a digital thermometer measuring the left axillary temperature as a reference temperature. The sensors were placed at 15-min intervals, and the temperature of the left axilla was measured separately and recorded simultaneously with the sensor. The data were then compared using analysis of variance, Pearson’s correlation test, and the Bland–Altman method.

Results:
The infants’ mean gestational age and weight were 36.09 and 2808.43 ± 240.654, respectively. The correlations between the temperature of the skin sensor on the left flank, right flank, back skin, liver area, and the area between the xiphoid and umbilicus skin sensors and the digital temperature on the left axilla were 0.804, 0.646, 0.723, 0.746, and 0.766, respectively. The extent of agreement between the temperature of the skin sensor on the left flank, right flank, back skin, liver area, and the area between the xiphoid and umbilicus skin sensors and the digital temperature on the left axilla was 1.528, 1.054, 0.948, 0.9003, and 0.9016, respectively.

Conclusion:
There was a significant correlation between the temperature of the skin sensors at the five sites and the digital thermometer in the left axilla as the reference temperature, which was measured simultaneously and separately at each skin sensor site.
Ready or Not, Here We Come: A Qualitative Study of the Transition From Graduate Medical Education to Independent Practice
Authors: Diemer Gretchen , Kuchera Timothy , Zavodnick Jillian , Frasso Rosemary , Jaffe Rebecca 
Published: February 2025

Background The transition from graduate medical education (GME) into independent practice is challenging for new attendings despite achieving “readiness for practice,” by Accreditation Council for Graduate Medical Education (ACGME) Milestones. Most medical literature on this transition is specialty-specific and rarely involves assessment of new-to-practice attendings (NTPAs).
Objective Lack of attending readiness results in compromised patient care. To inform GME leaders and managers, we sought to identify areas of struggle for NTPAs across specialties. With this information, we hope to spur national GME curriculum evolution, better support our NTPAs, and ultimately provide better patient care.
Methods Qualitative freelisting was used in 2021 to explore how NTPAs, educational program leaders, and managers perceive the transition struggles. Response lists were collected electronically, then cleaned and categorized by the research team using iterative inductive combination of similar concepts. Salience index scores (Smith’s S) were calculated and plotted graphically to identify inflection points for each group, above which domains were deemed salient.
Results One hundred eighty-six participants completed surveys, yielding 518 individual responses and a response rate of 34%. Of the ACGME competencies, systems-based practice domains were most frequently salient, including “workload” and “billing.” “Confidence,” “supervision,” “work-life balance,” “decision-making,” and “time management” were salient struggles in all groups. Each group had domains only achieving salience for them. Professional development domains including “confidence,” “imposter syndrome,” and “culture” achieved salience in different groups.
Conclusions This study identifies domains of struggle for NTPAs, which fall outside ACGME competency frameworks including workload, new environments, and professional development. Domains identified by NTPAs, program leaders, and managers were not identical.
A Visual Arts Activity to Support Residents as They Care for “Difficult Patients”
Authors: Quinn Mariah A. , Fletcher Kathlyn E. , Floden Sarah L. , Zelenski Amy B. 
Published: February 2025

Background Certain patients significantly challenge the care team, increasing the risk of burnout as clinicians struggle to perform their best work while meeting the needs of their patients. Imagining another’s perspective, a clinical empathy skill, can increase compassion and lower distress when interacting with these patients.
Objective To evaluate the effectiveness of an art-based perspective-taking activity on clinicians’ feelings of discomfort when anticipating encounters with challenging patients.
Methods This museum-based session was conducted from 2017 to 2022 (virtual sessions in 2020) by faculty trained in using arts-based methods to teach. Residents (n=142) in a university-based internal medicine residency program along with health professionals, trainees, and faculty (n=12) attending an international conference were invited to participate. Participants recalled a challenging patient, chose a piece of art that might be meaningful to this person, and discussed their choice and insights gained. Participants completed pre-post ratings of anticipated discomfort. Inaugural participants submitted written reflections on these ratings. Data were analyzed using paired t tests and content analysis.
Results Five 90-minute sessions were conducted with 65 internal medicine residents and 12 faculty; 75 of 77 total participants completed pre-post discomfort ratings (response rate 97.4%). Anticipated discomfort decreased after sessions (mean pre=5.38; post=4.13; P&lt;.01). Open-ended responses aligned with a transition from self to other focus in perspective-taking. Costs were minimized by using art from a campus museum, paper and pencil surveys, and faculty academic time.
Conclusions This innovative visual arts–based activity to increase empathy for challenging patients is simple, feasible, self-contained, and cost-effective.
Formulation and Evaluation of Natural-based Cosmeceutical Ointments: An Approach to Manage Dry Scalp Dandruff
Authors: Salako K.S. , Adegbiteb O. , Ani F. 
Published: February 2025

Background: Pityriasis capitis, commonly known as dandruff, is a prevalent, chronic scalp ailment that affects over half of the world's population. Dry scalp dandruff is a type of dandruff. Ointments are good examples of pharmacological formulations that have emollient effects on the scalp and hair. Thus, this study aimed at formulating cosmeceutical herbal ointment as an approach to manage dry scalp dandruff disorder.Methods: Phytochemical screening of Amla (Phyllanthus emblica Linn., family- Euphorbiaceae) powder and Avocado (Persea americana Mill., family- Lauraceae) oil was carried out. The ointments were formulated using shea butter as base. Physicochemical, cosmeceutical (conditioning) evaluations, draize skin irritancy test, and stability studies were also carried out.Results: The natural-based ointment formulations were cream to brown in colour, the formulations had flowery smell, smooth and oily to gritty and dry texture, pH range of 4.8-7.4. Viscosity was in the range of 20433 to 28007 cp. Spreadability was in the range of 28.49 to 85.24 g.cm/sec. Loss on drying was in the range of 1.77 to 6.73 %. Globule size was in the range of 0.2 – 2.0 µm. The cosmeceutical or conditioning evaluation showed the average score for shine /oiliness, softness and washability to be 2.6 to 4.6, 2.6 to 3.6 and 3.0 respectively. Draize skin irritancy test showed that there was no inflammation, oedema and erythema observed. The formulations exhibited stability in terms of colour, smell, texture and there was no syneresis observed, but there was a difference in the pH (4.96-7.02) of all the formulations.Conclusion: This study has shown that natural based cosmeceutical herbal ointment formulations may be used in managing dry scalp dandruff disorder through its conditioning activities.
VIR: from a small Bureau in the Russian Empire to the present-day National Center for Plant Genetic Resources
Authors: Loskutov Igor G , Ukhatova Yulia V , Khlestkina Elena K 
Published: February 2025

In 2024, the All-Russian Institute of Plant Genetic Resources (VIR), the world’s oldest scientific institution dedicated to plant genetic resources (PGR), celebrates its 130th anniversary. Founded as the Bureau of Applied Botany in the late 19th century, VIR has evolved into a globally recognized institute, currently also known as the National Center for Plant Genetic Resources. It preserves a collection of more than 320,000 unique accessions from 64 botanical families, 376 genera and 2,169 species. The Institute’s mission includes the systematic collection, comprehensive study, long-term conservation and sustainable utilization of PGR. The foundation for most of VIR’s research endeavours was laid by Nikolay Vavilov, a prominent botanist, geneticist, plant breeder and scientist with an encyclopedic scope of knowledge. A key strength of the Institute has always been its extensive cooperation with global, regional and international organizations, as well as research institutes, universities and breeding centres in many countries around the world. Today, as the National Center for PGR, VIR continues to build on this legacy. Its efforts include the development of a legislative platform for genetic resources in Russia and fostering international scientific cooperation on PGR, continuing the vision of Nikolay Vavilov.
Financial Performance in Relation to ESG and SDG: a Bibliometric Analysis
Authors: Cunea Miruna-Iuliana , Petrica Iuliana-Madalina , Bancu Emil-Adrian 
Published: February 2025

Objective: The objective of this study is to observe the interest of researchers regarding the association between financial performance with ESG and SDG.

Theoretical Framework: Although the association between financial performance and ESG and SDG is a widely debated topic in the specialized literature, to our knowledge, there is a gap concerning the comparative assessment of interest among academics, regarding the relationship between financial performance and ESG, respectively financial performance and SDG.

Method: The aim of this research is accomplished by conducting a bibliometric analysis, using VOSviewer and Microsoft Excel. The final sample for the research consists of 1025 papers for Panel A (financial performance - ESG) and 201 papers for Panel B (financial performance - SDG) extracted from the Web of Science (WoS) database.

Results and Discussion: The findings of this study include the number of publications over the years, a journals activity analysis, a countries activity analysis, a co-authorship analysis, the most cited articles and citation trends, and a representation of the most used keywords. The overall conclusion is that the relationship between financial performance with ESG and SDG is emphasized in the published articles.

Research Implications: The main contribution of this research resides in filling the studies on the association between financial performance in relation to ESG and SDG.

Originality/Value: This research contributes to the development of ESG disclosure and research and the achievement of SDG.
The Participation Model of the Indonesian Army in Supporting the National Food Security Strategy: a Case Study at Kodim 0816/Sidoarjo
Authors: Utomo Bambang , Marjono  , Tarno Hagus , Hidayati Bunga 
Published: February 2025

Objective: This research aims to explore the participation model of the Indonesian Army (TNI AD), particularly through Kodim 0816/Sidoarjo, in supporting the national food security strategy. The focus is on analyzing farmer empowerment approaches and the strategic distribution of resources implemented to improve the availability, affordability, and utilization of food.

Theoretical Framework: The theoretical framework of this research is based on the Empowerment-Agriculture Integration (EAI) Model and the Strategic Resource Distribution (SRD) Model. The EAI approach focuses on community empowerment through education and local resource management, while SRD emphasizes efficient resource allocation to ensure equitable food distribution.

Method: This study employs a qualitative approach with an empirical design. Data is collected through in-depth interviews, participatory observations, and documentation from key informants such as members of Kodim 0816, farmers, and representatives of the Agricultural Office. Data analysis is conducted inductively through reduction, presentation, and conclusion drawing.

Results and Discussion: The findings indicate that the participation model of the Indonesian Army through Kodim 0816/Sidoarjo includes training on modern agricultural technology, optimization of unused land, distribution of agricultural aid, farmer assistance, and food diversification. This model increases productivity by 20-30%, enhances land management efficiency, and improves farmer welfare, supporting the sustainability of local food security.

Research Implications: This research provides practical contributions to the development of national food security policies through the integration of the military's role in community empowerment strategies and resource distribution. The findings also provide a foundation for implementing similar programs in other regions with more structured and sustainable approaches.

Originality/Value: This research offers new insights into the strategic role of the Indonesian Army in supporting national food security through an integrated approach that combines community empowerment and efficient resource management, which has not been extensively explored in previous literature.
The Position of Female Instrumentary Witnesses in the Creation of Notarial Deeds from the Perspective of Islamic Law
Authors: Effendi Basri , Safrijal Airi , Mukhlis  
Published: February 2025

Objective: This study aims to investigate the position of female instrument witnesses in the creation of notarial deeds from the perspective of Islamic law.

Theoretical Framework: In this topic, the Sharia business currently is growing rapidly, and one important aspect of this business is the role of notaries in creating authentic deeds as written evidence in every legal relationship.

Method: The methodology adopted for this research was normative juridical research with an statutory approach, the conceptual approach, and the historical approach. This research also uses library studies to obtain primary and secondary legal materials.

Results and Discussion: The results obtained revealed this model is considered refer to the views of contemporary fiqh scholars. This is permissible considering that the testimony of men and women is equal.

Research Implications: This research's practical and theoretical implications are discussed, including how the results of In the practice of creating deeds for Sharia-compliant businesses, the witnesses are usually the employees at the notary's office, whether male or female. So the imbalance between male and female witnesses has implications for the validity of instrumental witnesses in the creation of deeds from the perspective of Islamic law.

Originality/Value: This research contributes to the literature is novelty because it was researched and studied in Indonesia, so it has its own uniqueness in the validity of instrumental witnesses in the creation of deeds from the perspective of Islamic law and has the opportunity to become a research reference for other researchers future.