bluuebunny/crossref_metadata_2025_split huggingface dataset:
SCI-VCF: a cross-platform GUI solution to summarize, compare, inspect and visualize the variant call format
Authors: Kamaraj Venkatesh , Sinha Himanshu 
Published: July 2024

Abstract
As genomics advances swiftly and its applications extend to diverse fields, bioinformatics tools must enable researchers and clinicians to work with genomic data irrespective of their programming expertise. We developed SCI-VCF, a Shiny-based comprehensive analysis utility to summarize, compare, inspect, analyse and design interactive visualizations of the genetic variants from the variant call format. With an intuitive graphical user interface, SCI-VCF aims to bridge the approachability gap in genomics that arises from the existing predominantly command-line utilities. SCI-VCF is written in R and is freely available at https://doi.org/10.5281/zenodo.11453080. For installation-free access, users can avail themselves of an online version at https://ibse.shinyapps.io/sci-vcf-online.
Semimetal-triggered covalent interaction in Pt-based intermetallics for fuel-cell electrocatalysis
Authors: Cheng Han , Gui Renjie , Chen Chen , Liu Si , Cao Xuemin , Yin Yifan , Ma Ruize , Wang Wenjie , Zhou Tianpei , Zheng Xusheng , Chu Wangsheng , Xie Yi , Wu Changzheng 
Published: July 2024

ABSTRACT
Platinum-based intermetallic compounds (IMCs) play a vital role as electrocatalysts in a range of energy and environmental technologies, such as proton exchange membrane fuel cells. However, the synthesis of IMCs necessitates recombination of ordered Pt-M metallic bonds with high temperature driving, which is generally accompanied by side effects for catalysts’ structure and performance. In this work, we highlight that semimetal atoms can trigger covalent interactions to break the synthesis-temperature limitation of platinum-based intermetallic compounds and benefit fuel-cell electrocatalysis. Attributed to partial fillings of p-block in semimetal elements, the strong covalent interaction of d-p π backbonding can benefit the recombination of ordered Pt-M metallic bonds (PtGe, PtSb and PtTe) in the synthesis process. Moreover, this covalent interaction in metallic states can further promote both electron transport and orbital fillings of active sites in fuel cells. The semimetal-Pt IMCs were obtained with a temperature 300 K lower than that needed for the synthesis of metal-Pt intermetallic compounds and reached the highest CO-tolerant oxygen reduction activity (0.794 A mg−1 at 0.9 V and 5.1% decay under CO poisoning) among reported electrocatalysts. We anticipate that semimetal-Pt IMCs will offer new insights for the rational design of advanced electrocatalysts for fuel cells.
The non-intervention principle and disclosure of information to beneficiaries: recent Jersey cases
Authors: Alexander Stephen , Bridgeford Andrew 
Published: July 2024

Abstract
Recent Jersey cases affirm the importance of the non-intervention principle, namely, that the court will not interfere before the trustees have acted to compel a particular exercise of power and that after they have acted it will not overturn their exercise of the power. A question not definitively settled is whether a trustee’s decision concerning the disclosure of trust information to a beneficiary constitutes an exception or whether the court’s role remains a more limited review. Two recent Jersey cases favour the former approach, and this jurisprudence is likely to be influential across other trust jurisdictions where the position has likewise not been decided.
VIIIRenaissance Drama: Excluding Shakespeare
Authors: Paravano Cristina , Ragni Cristiano , Enjo Yuri 
Published: July 2024

Abstract
This chapter has three sections: 1. Editions and Textual Matters: this will be available as a double section in the next edition of YWES; 2. Theatre History: this will also be available as a double section in the next edition of YWES; 3. Criticism. Section 3(a) General is by Cristina Paravano; section 3(b) Marlowe is by Cristiano Ragni; section 3(c) Jonson is by Yuri Enjo.
Tranexamic Acid Administered at Time of Hospital Admission Does Not Decrease Transfusion Rates or Blood Loss for Extracapsular Hip Fractures: A Double-Blinded Randomized Clinical Trial
Authors: Owen Aaron R. , Boe Chelsea C. , Kuttner Nicolas P. , Cancio-Bello Alexandra M. , Colbenson Kristina M. , Hidden Krystin A. , Barlow Jonathan D. , Cross William W. , Sems Stephen A. , Yuan Brandon J. 
Published: July 2024

OBJECTIVES:
To evaluate tranexamic acid (TXA) when administered immediately on hospital presentation in patients with extracapsular peritrochanteric hip fractures to determine its effect on (1) transfusion rates, (2) estimated blood loss, and (3) complications.

METHODS:

Design:
Prospective, double-blinded, randomized clinical trial.

Setting:
Single-center, Level 1 trauma center.

Patient Selection Criteria:
All patients with isolated OTA/AO 31-A fracture patterns from 2018 to 2022 were eligible for inclusion. Study drug was administered in the emergency department at the time of presentation—1-g bolus over 10 minutes followed by a 1-g infusion over 8 hours.

Outcome Measures and Comparisons:
The primary outcome was the rate of red blood cell transfusion hospital days 1–4. Secondary outcomes included estimated blood loss and complications including venous thromboembolic events, stroke, myocardial infarction, all-cause 90-day readmissions, and all-cause mortality.

RESULTS:
One hundred twenty-eight patients were included—64 patients were randomized to intravenous TXA and 64 patients to intravenous normal saline (ie, placebo). There was no difference in the rate of red blood cell transfusion between treatment arms between hospital days 1–4 (27% in the TXA arm vs. 31% in the placebo arm, P = 0.65). Patients randomized to placebo who required transfusion received a mean of 2.30 units compared with 1.94 units in the TXA cohort (P = 0.55). There was no difference in the estimated blood loss between hospital days 1–4. There was no difference in the incidence of postoperative complications including venous thromboembolic events, stroke, myocardial infarction, 90-day readmission, or death.

CONCLUSIONS:
The results of this study do not support the use of preoperative TXA for reducing blood loss for geriatric patients with extracapsular hip fractures.

LEVEL OF EVIDENCE:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.
What is the Utilization and Impact of Advanced Imaging for Tibial Tubercle Fractures? An Analysis of 598 Patients From the Tibial Tubercle Study (TITUS) Group
Authors: Shen Peter C. , Williams Brendan A. , Edobor-Osula O. Folorunsho , Blanco John S. , Crawford Lindsay M. , Greenhill Dustin A. , Griffith Alexander H. , Kaushal Neil K. , Kell David M. , Rashiwala Abhi , Schlechter John A. , Thomas Evelyn S. , Tornberg Haley N. , Patel Neeraj M. 
Published: July 2024

Background:
Given the rare nature of tibial tubercle fractures, previous studies are mostly limited to small, single-center series. This results in practice variation. Previous research has shown poor surgeon agreement on utilization of advanced imaging, but improved evidence-based indications may help balance clinical utility with resource utilization. The purpose of this study is to quantify diagnostic practices for tibial tubercle fractures in a large, multicenter cohort, with attention to the usage and impact of advanced imaging.

Methods:
This is a retrospective series of pediatric tibial tubercle fractures from 7 centers between 2007 and 2022. Exclusion criteria were age above 18 years, missing demographic and pretreatment data, closed proximal tibial physis and tubercle apophysis, or a proximal tibia fracture not involving the tubercle. Demographic and injury data were collected. Fracture classifications were derived from radiographic evaluation. The utilization of advanced imaging was recorded as well as the presence of findings not identified on radiographs. Standard descriptive statistics were reported, and χ2 tests were performed (means reported±SD).

Results:
A total of 598 patients satisfied the inclusion criteria, of which 88.6% (530/598) were male with a mean age of 13.8±1.9 years. Internal oblique x-rays were obtained in 267 patients (44.6%), computed tomography (CT) in 158 (26.4%), and magnetic resonance imaging (MRI) in 64 (10.7%). There were significant differences in the frequency at which CT (7.2% to 79.4%, P<0.001) and MRI were obtained (1.5% to 54.8%, P<0.001). CT was obtained most frequently for Ogden type IV fractures (50/99, 50.5%), and resulted in novel findings that were not visualized on radiographs in a total of 37/158 patients (23.4%). The most common finding on CT was intra-articular fracture extension (25/37). MRI was obtained most frequently for Ogden type V fractures (13/35, 37.1%), and resulted in novel findings in a total of 31/64 patients (48.4%). The most common finding was patellar tendon injury (11/64), but only 3 of these patients required tendon repair.

Conclusions:
Substantial variation exists in the diagnostic evaluation of tibial tubercle fractures. CT was most helpful in clarifying intra-articular involvement, while MRI can identify patellar tendon injury, periosteal sleeve avulsion, or a nondisplaced fracture. This study quantifies variation in diagnostic practices for tibial tubercle fractures, highlighting the need for evidence-based indications for advanced imaging.

Level of Evidence:
Level III.
Long-term exposure to transportation noise and obesity: A pooled analysis of eleven Nordic cohorts
Authors: Persson Åsa , Pyko Andrei , Stucki Lara , Ögren Mikael , Åkesson Agneta , Oudin Anna , Tjønneland Anne , Rosengren Annika , Segersson David , Rizzuto Debora , Helte Emilie , Andersson Eva M. , Aasvang Gunn Marit , Gudjonsdottir Hrafnhildur , Selander Jenny , Christensen Jesper H. , Leander Karin , Mattisson Kristoffer , Eneroth Kristina , Barregard Lars , Stockfelt Leo , Albin Maria , Simonsen Mette K. , Spanne Mårten , Roswall Nina , Tiittanen Pekka , Molnár Peter , Ljungman Petter L.S. , Männistö Satu , Yli-Tuomi Tarja , Cole-Hunter Thomas , Lanki Timo , Lim Youn-Hee , Andersen Zorana J. , Sørensen Mette , Pershagen Göran , Eriksson Charlotta 
Published: July 2024

Background:
Available evidence suggests a link between exposure to transportation noise and an increased risk of obesity. We aimed to assess exposure-response functions for long-term residential exposure to road traffic, railway and aircraft noise, and markers of obesity.

Methods:
Our cross-sectional study is based on pooled data from 11 Nordic cohorts, including up to 162,639 individuals with either measured (69.2%) or self-reported obesity data. Residential exposure to transportation noise was estimated as a time-weighted average Lden 5 years before recruitment. Adjusted linear and logistic regression models were fitted to assess beta coefficients and odds ratios (OR) with 95% confidence intervals (CI) for body mass index, overweight, and obesity, as well as for waist circumference and central obesity. Furthermore, natural splines were fitted to assess the shape of the exposure-response functions.

Results:
For road traffic noise, the OR for obesity was 1.06 (95% CI = 1.03, 1.08) and for central obesity 1.03 (95% CI = 1.01, 1.05) per 10 dB Lden. Thresholds were observed at around 50–55 and 55–60 dB Lden, respectively, above which there was an approximate 10% risk increase per 10 dB Lden increment for both outcomes. However, linear associations only occurred in participants with measured obesity markers and were strongly influenced by the largest cohort. Similar risk estimates as for road traffic noise were found for railway noise, with no clear thresholds. For aircraft noise, results were uncertain due to the low number of exposed participants.

Conclusion:
Our results support an association between road traffic and railway noise and obesity.
Change in Visual Acuity of Patients With Fuchs Endothelial Corneal Dystrophy Over 1 Year
Authors: Dorado-Cortez Oliver , Crouzet Emmanuel , Trone Marie Caroline , Gain Philippe , He Zhiguo , Vaitinadapoule Hanielle , Mentek Marielle , Mascarelli Frédéric , Poinard Sylvain , Yasunaga Mari , Nishiuchi Go , Koizumi Noriko , Okumura Naoki , Thuret Gilles 
Published: July 2024

Purpose:
To determine whether the clinical and paraclinical course of Fuchs endothelial corneal dystrophy (FECD) over 1 year is related to the extent of triplet repetition in the transcription factor 4 (TCF4) gene.

Methods:
A prospective study with a 1-year follow-up was conducted. A total of 104 patients (160 eyes) with FECD and an equivalent number of age- and sex-matched control subjects without FECD were included. At inclusion, the corneas were graded using the modified Krachmer grade (KG) and patients were genotyped for the number of trinucleotide repeats (TNRs) in the TCF4 gene by the short tandem repeat assay. Visual acuity, Scheimpflug tomographic features, and the Visual Function and Corneal Health Status using a visual disability instrument were measured on 2 visits at 1-year intervals.

Results:
KGs ranged from 1 to 6, and 46% of eyes had grades 1 to 4. 71% of the patients harbored TNR expansion (>40) versus 13% in control subjects (P < 0.001). Severity at inclusion was higher in the presence of TNR expansion when considering eyes independently (mean grade ±SD, 4.08 ± 1.42) without TNR expansion and 4.66 ± 1.27 with TNR expansion (P = 0.024). In 1 year, the ETDRS score significantly decreased by −2.97 (95% confidence interval −4.69 to −1.26, P = 0.001) and the ETDRS score with glare by −4.25 (95% confidence interval −6.22 to −2.27, P < 10−5). There was no relationship between the rate of decline and TNR expansion or KG. Central corneal thickness and Visual Function and Corneal Health Status scores did not significantly vary.

Conclusions:
It is possible to measure a subtle progression of FECD over a period as short as 1 year. We did not find a relationship between the presence of TNR expansion and the speed of deterioration over 1 year. This work should facilitate the design of future clinical trials on FECD.
Risk factors for cement leakage after percutaneous vertebral augmentation for osteoporotic vertebral compression fractures: a meta-analysis
Authors: Wu Yu , Zhou Zelin , Lu Guoliang , Ye Linqiang , Lao Aotian , Ouyang Shuai , Song Zefeng , Zhang Zhigang 
Published: July 2024

Background:
Osteoporotic vertebral compression fractures (OVCF) may necessitate percutaneous vertebral augmentation (PVA), a procedure not without its risks. One notable complication is cement leakage (CL), which can cause significant distress in patients. Despite its clinical importance, there remains a paucity of meta-analyses investigating these complications and their management in the existing literature.

Material and methods:
The authors systematically reviewed PubMed, Cochrane Library, Embase, and Web of Science databases up to February 2024 to identify studies examining CL following PVA treatment in OVCF. The authors assessed the quality of eligible cohort studies using the Newcastle–Ottawa Scale (NOS), extracted data on incidence, identified risk factors for CL, and conducting meta-analysis with Revman 5.2 software. The authors calculated odd ratios (OR) and mean differences (MD) with 95% CI applying random-effects models.

Results:
The authors identified twelve cohort studies that matched our strict inclusion criteria. These studies included a total of 2388 patients and 3392 vertebrae. CL was identified in 1132 vertebrae. Notable risk factors for CL included compromised cortical bone integrity (OR 5.00, 95% CI 3.01–8.29, P<0.00001), presence of intravertebral vacuum clefts (OR 1.68, 95% CI 1.07–2.65, P=0.03), basivertebral foramen sign (OR 1.77, 95% CI 1.09–2.89, P=0.02), and volume of cement used (MD 0.75, 95% CI 0.41–1.10, P<0.0001).

Conclusion:
The authors’ findings underscore the significance of cortical bone integrity, intravertebral vacuum cleft, basivertebral foramen sign, and cement volume as principal determinants of CL risk in PVA for OVCF. These insights advocate for tailored surgical strategies to mitigate the risk of CL in this patient population.
Clinical significance of circulating tumor cells in colorectal cancer with peritoneal metastases: a prospective cohort study using a novel method for monitoring treatment response, and assessing minimal residual disease
Authors: Frühling Petter , Moberg Louice , Ghanipour Lana , Birgisson Helgi , Graf Wilhelm , Ericsson Christer , Cashin P.H. 
Published: July 2024

Background:
The treatment for patients with colorectal cancer with metastases to the peritoneum is complex and may involve both surgery and chemotherapy. Circulating tumor cells (CTCs) have been poorly investigated in peritoneal metastatic colorectal cancer. The aim of the study is to examine the role of CTCs as a biomarker for monitoring disease progression, treatment response, and residual disease using CellMate – a new promising in vitro diagnostic platform technology.

Materials and methods:
The authors prospectively followed the clinical outcomes of 46 patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal cancer with peritoneal metastases and examined whether CTCs were present the week of surgery. The CTC measurements were made with the CellMate technology, which is a platform technology to detect CTCs based on the difference in biomechanical properties compared to blood resident cells. The study was registered online (ClinicalTrials.gov).

Results:
CTCs were detected in 17 (37%) patients. The presence of CTCs was associated with shorter recurrence-free survival and overall survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Both recurrence-free survival (HR 4.00, 95% CI: 1.15–13.9; P=0.029) and overall survival (HR 5.91; 95% CI: 1.18–29.7; P=0.03) were significantly worse if CTCs were detected after neoadjuvant treatment. In the subgroup of patients with CTCs detected, adjuvant therapy tended to improve the prognosis while in CTC negative patients it did not.

Conclusions:
Pending a prospective multicenter trial to validate these findings, CTCs may in the future be used as a dynamic personalized biomarker for prognostication, predicting response to therapy, and for monitoring disease progression in colorectal cancer with metastases to the peritoneum.
Effectiveness of Therapeutic Exercise for Children Undergoing Treatment for Cancer: A Systematic Review
Authors: Linero-Bocanegra Miriam , García-Conejo Celia , Ramírez-Pérez Laura , Cuesta-Vargas Antonio Ignacio , Trinidad-Fernández Manuel 
Published: July 2024

Purpose:
To evaluate the effectiveness of therapeutic physical exercise (TPE) interventions on the physical functioning, psychosocial well-being, and quality of life (QoL) of children undergoing treatment for cancer.

Method:
Systematic review: databases were searched in April 2023. Selection criteria: children (<18 years old) undergoing treatment for cancer or a malignant neoplasm, randomized controlled trial design, utilization of TPE, and including physical and psychosocial outcomes. Internal validity was measured with Physiotherapy Evidence Database scale.

Results:
Seven randomized controlled trials were included. Most studies showed that strength, fatigue, and QoL improved after the intervention. Cardiorespiratory capacity through 6-minute walk test and physical activity levels were better in the experimental groups. No changes were noted in other variables.

Conclusions:
This review supports the importance of a TPE program during cancer treatment, with the aim of maintaining physical capacities and counteracting physical inactivity.
Chronic Pain Following Breast Reconstruction
Authors: Shiraishi Makoto , Sowa Yoshihiro , Inafuku Naoki , Sunaga Ataru , Yoshimura Kotaro , Okazaki Mutsumi 
Published: July 2024

Background
Breast cancer survival rates have increased significantly, underscoring the importance of enhancing long-term health-related quality of life. Breast reconstruction following mastectomy has emerged as a common approach that contributes to improved health-related quality of life. Nonetheless, chronic pain following breast reconstruction is a prevalent issue that has a negative impact on overall well-being.

Methods
To examine recent findings on chronic pain after breast reconstruction and progress in pain management, we performed a review of the literature through independent searches using the MEDLINE database within NIH National Library of Medicine PubMed.

Results
The review suggested that autologous reconstruction causes chronic postsurgical pain, especially at specific donor sites, whereas implant-based reconstruction does not seem to increase the risk of chronic pain. Moreover, certain operational and patient factors are also associated with chronic pain. Appropriate pain management can reduce chronic pain and prevent the transition from acute to chronic pain.

Conclusion
This scoping review evaluated the characteristics of long-term chronic pain after breast reconstruction. The findings provide patients with important treatment information and will assist with their decision on their preferred treatment.
The Effect of Bowel Anastomosis on Outcomes in Complex Abdominal Wall Reconstruction
Authors: Shauly Orr , Marxen Troy , Menon Ambika , Rumbika Savanah , Ash Makenna , Jean-Baptiste Omar , Losken Albert 
Published: July 2024

Background
In patients who require complex abdominal wall reconstruction (CAWR), the need for a bowel anastomosis could impact procedure choice and outcome. In this retrospective cohort study, we examine the effect of bowel anastomosis on complications and hernia recurrence.

Methods
All patients who underwent CAWR between 2011 and 2021 by the senior author were reviewed in a retrospective cohort analysis. Patients were included if they met the above criteria. Patients were excluded if they did not undergo the above procedure or if they underwent a different procedure simultaneously. Univariate analysis was performed for patients who underwent bowel anastomosis, and multiple variable logistic regression analysis was performed with respect to overall complications.

Results
A total of 264 patients underwent CAWR over a 10-year interval. A total of 41 patients underwent bowel anastomosis (16%), and 223 patients (84%) underwent CAWR without bowel anastomosis. Mean patient age was 55.50 ± 11.55 years. Mean patient body mass index was 32.36 ± 7.31 kg/m2. Mean follow-up time was 10.20 months. There was a significant difference in hernia repair etiology, with higher rates of recurrent hernia repair among patients receiving bowel anastomosis (odds ratio, 2.98; 95% confidence interval, 1.49–5.95; P = 0.0018). Acellular dermal matrix was used more frequently in patients who required a bowel anastomosis (odds ratio, 3.74; 95% confidence interval, 1.75–8.00; P = 0.0018). Major and minor complications were also significantly higher in this cohort. Regression analysis for overall complications revealed the presence of bowel anastomosis, fascial repair technique, and follow-up time as independent predictors of overall complications.

Conclusion
Bowel anastomosis performed at the time of CAWR significantly increased the rate of overall and major complications but did not predict hernia recurrence. Plastic surgeons should utilize this information in counseling patients and in deciding the most appropriate hernia repair technique.