bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Physical Activity Intensity On All-cause and Cardiovascular Mortality in Diabetic Patients
Authors: Wang Yali , Sun Lingling , Zhang Zhi , Jin Hongfeng , Tang Lijiang , Du Changqing , Liu Xiaowei 
Published: February 2025

Abstract

Background To assess the association between physical activity (PA) and mortality risk, few data are available to guide clinical recommendations for individuals with high levels of PA in the presence of clinically diagnosed diabetes.Methods Data on diabetic patients (aged 18 to 85 years) were acquired from the United States (US) National Health and Nutrition Examination Survey (NHANES) 1999–2018. The patients were divided into three groups based on the level and frequency of PA: a) sedentary (n = 2,152), b) moderate PA (n = 504), and c) vigorous PA (n = 1,708). Logistic regression analysis was used to determine the relationship between PA and all-cause mortality (ACM) or cardiovascular mortality (CVM) in diabetic patients.Results Among 4,364 adult respondents (54% men, 46% women, mean age 60.44 ± 15.4 years), 50.69% reported adequate PA. During the study, there were 283 (6.48%) deaths from cardiovascular disease (CVD) and 937 (21.47%) deaths from all causes. The incidence of all-cause or CVM was highest in the sedentary group. Patients who undertook sedentary PA had the highest risk of ACM (odds ratio [OR] 2.18; 95% confidence interval [CI] 1.69–2.82; P < 0.01) or CVM (OR 1.69; 95% CI 1.07–2.66; P < 0.01) compared to those in the moderate PA group. Vigorous PA did not further improve efficacy.Conclusions There is evidence that moderate PA is associated with reduced all-cause or CVM in diabetes after a decade of follow-up, but vigorous PA is not associated with further reductions in all-cause or cardiovascular mortality.
Why are iron chelators not as effective as artemisinin in killing malaria parasites?
Authors: Sun Jun , Fang Chuantao , Si Wenwen , Qin Xixi , Wang Fei , Li Yanna , Yan Xiaoli 
Published: February 2025

Abstract

Background
It is currently established that artemisinin kills malaria parasites by disrupting iron or haem utilization. Similarly, iron chelators also eliminate these parasites by interfering with iron utilization. However, the antimalarial effect of artemisinin is significantly greater than that of iron chelators. Understanding the differences between these two mechanisms is beneficial for elucidating the antimalarial action of artemisinin and for developing strategies to enhance artemisinin-based combination therapies.
Methods
We employed single-cell RNA sequencing analysis to assess the sensitivity of different stages of P. falciparum 3D7 to dihydroartemisinin (DHA) and desferrioxamine (DFO) at 3, 9, and 24 hours post-treatment. Additionally, we compared the distinct antimalarial effects of artemether, DHA, and DFO on malaria parasites in vitro and in vivo. Transmission electron microscopy (TEM) was utilized to observe the effects of artemisinin on the parasites.
Results
Our findings indicate that P. falciparum 3D7 is more sensitive to DFO than DHA at 12, 18, 24, and 30 hours post-infection; however, 24 hours post-treatment, all stages exhibit greater sensitivity to DHA than DFO. Notably, at 3 hours post-treatment with DFO and DHA, the number of various stages changed minimally, yet iron utilization-related genes were significantly upregulated only in the DHA treatment group. Gene expression analysis revealed that the actions of DFO and DHA result in the expression of different genes, particularly those involved in ribosome synthesis and protein translation in the DHA treatment group. Although both DHA and DFO can reduce the infection rate of P. falciparum 3D7 in vitro, DFO fails to inhibit the growth of Plasmodium yoelii 17XNL in vivo. Furthermore, the combined effect of DHA and DFO is weaker than that of DHA alone. TEM analysis demonstrates that artemether disrupts haem aggregation within the digestive vacuole of malaria parasites.
Conclusions
While both artemisinin and iron chelators can disturb or prevent iron utilization, they kill malaria parasites through distinct mechanisms and yield different effects. Notably, the accumulation of artemisinin and its unique interaction with haem in the digestive vacuole facilitate a more efficient and specific antimalarial effect of artemisinin.
Real-space imaging of ultrafast electron dynamics and subsequent crystallographic dynamics via photo-induced phase transition
Authors: Fukumoto Keiki , Onda Ken , Tanaka Takanori , Kusakabe Koichi , Yamochi Hideki , Adachi Shin-ichi , Koshihara Shin-ya 
Published: February 2025

Abstract

Photo-induced phase transition (PIPT) involves substantial changes in both electronic and crystallographic structures caused by electron excitations. Because PIPT is ultrafast and exhibits inhomogeneous behaviour, its fundamental processes, in particular how the ultrafast dynamics of photoexcited electrons trigger lattice deformation and the time scales involved, remain poorly understood. In this study, the dynamics of the photoexcited electrons and the subsequent volume change of organic charge transfer complexes are directly visualised simultaneously in the time and energy domains using photoemission electron microscopy with a femtosecond pulsed laser as the excitation source. The results show that an anisotropic volume change of a few percent is initiated following the accumulation of electrons in unoccupied states over approximately a picosecond.
The mechanism of charge transfer between quantum dots and redox molecules
Authors: Vogel Yan , Boeije Willemijn , Steekelenburg Lotte van , Vollebregt Demi , Ubbink Reinout , Chen Hua , Younesi Ali , Ulbricht Ronald , Jager Wolter , Grozema Ferdinand , Houtepen Arjan 
Published: February 2025

Abstract

Charge transfer between quantum dots (QDs) and redox molecules is not well described by the Marcus theory, the hall-mark theory for charge transfer in molecular systems. The Marcus inverted region, where the rate decreases with increasing the free energy difference, has never been observed in QDs. The previously reported hypothesis for the absence of the Marcus inverted region in QDs is an Auger-assisted charge transfer pathway. Here, we show that the Auger hypothesis does not hold to experimental tests. Instead, our experimental results suggest the presence of a distribution of molecular configurations on the QD surface that results in multiple energy surfaces. We measured the rate constants for two processes where Auger is either allowed or not: charge separation and charge recombination. We used ultrafast transient absorption spectroscopy to probe the rate of charge separation and recombination between PbS QDs and ferrocene derivatives ligands bound to their surface. We find that the rate constant for both charge separation and recombination increase by increasing the free energy difference, are temperature-independent, and increase with the number of molecular acceptors. All these results are against theoretical predictions for an Auger-assisted charge transfer and suggest the presence of multiple molecular configurations with charge transferring through the most favorable pathway.
The Effects of Arts-Based Interventions in the Treatment and Management of Non-Communicable Diseases: An Umbrella Review and Meta-Analyses
Authors: de Witte* Martina , Bradt* Joke , Aithal Supritha , Flynn Libby , Karkou Vicky , Koch Sabine , Orkibi Hod , Sajnani Nisha , Berberian Marygrace , Fietje Nils , Miranda Jaime , Baker** Felicity A. , Lampit** Amit 
Published: February 2025

Abstract

Background A considerable number of published reviews have addressed the treatment effects of arts-based interventions for health outcomes in people with noncommunicable diseases (NCDs). It is important to summarise this evidence base to inform policy and practice, identify research gaps, and provide research recommendations.
Methods We searched The Cochrane Database of Systematic Reviews, Web of Science, CINAHL, Medline, PsycINFO, and Embase for systematic reviews published between database inception and 7 September 2023. We included systematic reviews (SR) with meta-analyses that summarised the effects of arts-based interventions on psychological, physical, cognitive functioning, or quality of life outcomes in people with cancer, cardiovascular disease (CVD), chronic respiratory disease (CRD), diabetes, mental health conditions, or neurological conditions. Eligible effect sizes (ES) were converted to standardized mean difference (SMD) with 95% confidence intervals (CI). Overall ES were calculated for each NCD population as well as across the four outcome domains, supplemented with subgroup analysis on study-, outcome-, and intervention variables. For all meta-analyses, we used restricted likelihood multilevel meta-analysis to account for non-independence of ES within individual meta-analyses. We assessed methodological quality using the Measurement Tool to Assess Systematic Reviews-2 checklist. This umbrella review was registered with PROSPERO (CRD42023493088).
Findings Our search resulted in 3,885 unique citations, of which 150 SR (including 576 ES) were included in our analyses. Music and dance interventions contributed 86.6% of ES estimates. We found a small-to-medium overall effect for neurological conditions (SMD 0.40, 95% CI 0.30–0.50) and medium effects for cancer (SMD 0.52, 95% CI 0.38–0.66), CVD (SMD 0.52, 95% CI 0.35–0.71), mental health conditions (SMD 0.53, 95% CI 0.39–0.68), and CRD (SMD 0.76, 95% CI 0.38–1.13). Most reviews were of low methodological quality.
Interpretation Our findings indicate that people with NCDs may benefit from arts-based interventions for physical, psychological, cognitive functioning and QoL outcomes. Therefore, arts-based interventions may be a valuable addition to traditionally first-line treatments such as psychotherapies, pharmacotherapies, and standard medical treatment for NCDs.

*Martina de Witte and Joke Bradt are co-primary authors.
**Felicity Baker and Amit Lampit are co-supervising authors.
Abrupt change in Arctic Sea Ice Volume
Authors: Steene Rebekka , Rypdal Martin , Aksamit Nikolas 
Published: February 2025

Abstract

Sea ice is a key component of the Arctic climate system. Arctic sea ice extent has decreased steadily, as global warming has manifested. The evolution of the pan-Arctic sea ice volume is, however, sparsely represented in studies, and the intricate coupling to other climate system components is still being unravelled. In this study, we look at sea ice volume in the Arctic and show how its response to increasing temperatures has changed in recent years. Using a Bayesian statistical model framework, we detect changepoints in trends in reanalysis data of sea ice volume. We further compare these findings with climate model data and find a similar behaviour in several models. Our results suggest that as global temperature increases, there is a temperature threshold at which the Arctic sea ice volume experiences an abrupt change. The abrupt change primarily originates from loss of sea ice thickness in the Canada Basin. This nonlinear response demonstrates that it does not suffice to merely consider ice extent or area when evaluating potential tipping points in Arctic sea ice, and cements the importance of ice volume in the total Arctic energy budget.
Ultrafast Switching and High-Endurance Nonvolatile Memory Using Ferroelectric Janus Monolayers
Authors: Lim Seong Chu , Duong Ngoc Thanh , Krishna Swathi , Nguyen Minh Chien , Kim Hang Sik , Gul Hamza , Choi Soo Ho , Kim Minjeong , Tran Thi Uyen , Dat Vu Khac , Do Van Dam , Nguyen Huong Thi Thanh , Yu Woo Jong , Kim Young-Min , Kim Ki Kang 
Published: February 2025

Abstract

The discovery of two-dimensional semiconducting ferroelectric (SFe) materials marks a pivotal step toward the commercialization of ferroelectric random-access memory. Despite their potential as ideal platforms for ultrafast switching and ultralow power consumption, SFe monolayers remain unexplored. Here, we demonstrate an SFe field-effect transistor based on monolayer Janus MoSeS, integrated with a ZrO2 high-κ (κ denotes dielectric constant) gate dielectric. The inherent non-centrosymmetry of the Janus structure leads to gate-switchable spontaneous out-of-plane polarity. The device exhibits counterclockwise memory windows of ~5 V, an on/off ratio exceeding 107 at zero gate bias, and an extrapolated retention time of up to 10 years. It also achieves fatigue-free endurance over 4 million cycles and ultrafast responses to 36 ns voltage spikes, resulting in ultralow power consumption of 120/98 fJ per program/erase cycle. These findings establish Janus monolayers as promising candidates for next-generation nonvolatile memory and neuromorphic computing applications.
Home measurement of 24-hour corticosteroid dynamics in primary aldosteronism
Authors: Grytaas Marianne A. , Upton Thomas , Marinelli Isabella , Methlie Paal , Øksnes Marianne , Vassiliadi Dimitra A. , Bensing Sophie , Russell Georgina , Løvås Kristian , Margaritopoulos Dimitris , Botusan Ileana R. , Simunkova Katerina , Balomenaki Maria , Berinder Katarina , Lombard Belinda , Sjøgren Thea , Løvik Ida , Oftedal Bergithe E. , Heie Anette , Ueland Grethe Å. , Kämpe Olle , Tsagarakis Stylianos , Lightman Stafford L. , Zavala Eder , Husebye Eystein S. 
Published: February 2025

Abstract

Primary aldosteronism (PA) affects 5–20% of the hypertensive population and is associated with increased cardiovascular and metabolic risks compared with primary hypertension. PA is significantly underdiagnosed partly due to our inability to capture the pulsatile variability of aldosterone over 24 hours in clinical settings. To gain insight into steroid secretion patterns in PA we applied multiplex 24-hour profiling of free corticosteroids concentrations in subcutaneous tissue microdialysate in 60 PA patients and 215 healthy individuals in a home setting (NCT02934399). PA profiles displayed a diurnal, pulsatile hypersecretion of aldosterone compared with healthy participants. Nocturnal and early morning hypersecretion of aldosterone and the hybrid steroids 18-hydroxycortisol and 18-oxocortisol enabled the identification of unilateral PA cases, candidates for surgical treatment. Indeed, normalisation of aldosterone hypersecretion was observed after adrenalectomy. Using dynamic markers extracted from the 24-hour time series our machine learning classifier achieved sensitivity of 88% and specificity of 80% to diagnose PA. We demonstrate that 24-hour dynamic hormone profiling in the home setting has the potential to transform endocrine diagnostics from assessing single point hormone levels to evaluation of dynamic patterns, which can change clinical practice not only for the diagnosis of PA, but also for other hormone excess and deficiency syndromes.
ЭЛЕМЕНТЫ ЕСТЕСТВЕННОНАУЧНЫХ КОНЦЕПЦИЙ АРИСТОТЕЛЯ В СРЕДНЕВЕКОВОЙ ОНЕЙРОКРИТИКЕ
Authors: ПЕТРОВА М.С. 
Published: February 2025

В статье предпринята попытка показать, как рано, в какой степени и каком виде в текстах европейских средневековых авторов, применительно к их психологическим и физиологическим представлениям о снах, видениях и наступлении сна, начинают проявляться элементы естественнонаучных концепций, восходящих к Аристотелю. Анализируются теории Гильома из Конша ( De phil. mundi XXI - XXII) с учётом его глосс на Макробиев Комментарий на ‘ Сон Сципиона ', и пс.-Августина ( De sp. et an. XXV).
The paper is dedicated to the problem of perception of Greek knowledge in the Middle Ages. How early it could have begun; to what extent and in what form the ingredients of Aristotle's theories began to appear in the texts of the European medieval authors on dreams, visions and the occurrence of sleep? The theories of William of Conches ( De phil. mundi XXI-XXII), including his glosses on Macrobius' Commentary on the ‘ Dream of Scipio ', and ps.-Augustine ( De sp. et an. XXV) are analyzed. It is shown that their texts contain the synthesis of different, non-direct psychological and physiological Greek concepts, in which one can see not only the influence of Platonic and Neoplatonic doctrines, but also the ingredients of the Aristotelian theories.
ПОНЯТИЯ NATURA NATURANS И NATURA NATURATA В ФИЛОСОФИИ СПИНОЗЫ КАК ВОЗМОЖНЫЕ КОРРЕЛЯТЫ ДВУХ ЕВРЕЙСКИХ ТЕРМИНОВ ДЛЯ ОБОЗНАЧЕНИЯ "ПРИРОДЫ": TÔLEḎEṮ / TÔLĀḎĀH И ṬEḆAʿ
Authors: ТАНТЛЕВСКИЙ И.Р. 
Published: February 2025

Автор предполагает, что Спиноза соотносил в своей философской системе латинское понятие Natura naturans, т. е. «Природа порождающая», с еврейским термином tôleḏeṯ / tôlāḏāh (var.: tôlāḏ ), по корню: «Природа как порождение » (в смысле активности природы), а понятие Natura naturata, т. е. «Природа порожденная», с еврейским термином ṭeḇa ʿ, по корню: «природа- отпечаток ».
The author assumes that Spinoza correlated his notion Natura naturans with Hebrew term t?le?e? / t?l???h (var.: t?l??), i.e., according to its root, the “Nature as begetting”; as for his notion Natura naturata, he could correlate it with the Hebrew term ?e?a?, i.e., according to its root, the “Nature as imprint”.
РЕКОНСТРУКЦИЯ ИДЕЙ АРИСТОТЕЛЯ В ИСТОРИКО-ФИЛОСОФСКОМ НАСЛЕДИИ ГАНСА КЕЛЬЗЕНА
Authors: ДИДИКИН А.Б. 
Published: February 2025

В небольшой статье автор касается серии работ Ганса Кельзена, посвященных античной политической мысли, в особенности его The Philosophy of Aristotle and Hellenic-Macedonian Policy. Как представляется, эти сравнительно малоизвестные сочинения знаменитого философа права все еще могут заинтересовать современных историков античной философии.
In a short note, the author outlines a series of Hans Kelsen’s studies dedicated to Ancient political thought, esp. his The Philosophy of Aristotle and Hellenic-Macedonian Policy. He believes that these relatively neglected minor studies of the famous philosopher of law could still be of interest to contemporary classicists and historians of philosophy.
НАТУРАЛИСТИЧЕСКИЕ И АНТИНАТУРАЛИСТИЧЕСКИЕ АСПЕКТЫ АРИСТОТЕЛЕВСКОГО ПОНИМАНИЯ ВРЕМЕНИ
Authors: КУЛИКОВ С.Б. 
Published: February 2025

В статье представлен опыт анализа аристотелевской концепции времени, изложенной в «Физике». Автор обсудил основания критики этой концепции со стороны Хайдеггера, согласно которой Аристотель был одним из основоположников классического или так называемого «расхожего» толкования времени. В постклассический период данное толкование развивал Августин, а в позднейшую эпоху Кант и Гегель довели его до логического завершения. Автор обосновал тезис, что даже если пост-аристотелевская мысль и Гегель, как ее завершитель, действительно понимали время во многом натуралистично, то у самого Аристотеля прослеживаются как натуралистические, так и антинатуралистические варианты интерпретации времени. В результате именно Аристотель заложил основы в том числе и экзистенциального понимания времени, поспособствовав тем самым формированию европейской рациональности во всем богатстве ее форм и проявлений.
In the article, I discuss the Heideggerian criticism of the Aristotelian concept of time. Heidegger thought that it was Aristotle who is to be blamed for so-called “ordinary” interpretation of time. Later on, Augustine developed this interpretation, while Kant and Hegel brought it to a logical end. The author observes that even if the post-Aristotelian thought and Hegel as its embodiment understood time in many respects naturalistically, we might trace both naturalistic and anti-naturalistic ways of interpretation of time in Aristotle. It appears therefore that Aristotle had also laid the foundations of existential comprehension of time, having influenced thereby the formation of the European rationality in all variety of its forms and manifestations.
СОЦИОЛИНГВИСТИЧЕСКИЕ АСПЕКТЫ ФИЛОСОФСКОЙ РИТОРИКИ КИНИКОВ
Authors: НАЙМАН Е.А. 
Published: February 2025

Данная статья посвящена анализу особенностей кинической коммуникации и проблем ее интерпретации. В работе осуществляется попытка использования социологической теории самовыражения И. Гофмана и социально антропологической теории невербальной коммуникации Э. Холла при интерпретации философской риторической практики кинизма. Существенную помощь при анализе риторики киников оказывают современные исследования Дональда Летейнера и Роберта Брэнхэма. Автор утверждает, что важнейшими признаками кинической философии являются театральность, трансгрессивные формы коммуникации, использование невербальных средств аргументации и предпочтение литературного жанра хрии. Несмотря на то, что театральность самовыражения киника осуществляется в различных стилистических регистрах, автор убежден в том, что ее наиболее яркое выражение наблюдается в невербальных компонентах риторической практики. В статье анализируются основные принципы кинического исполнения, специфика взаимодействия киников с социальным окружением, использование тела в качестве риторического тропа, рассматриваются различные невербальные средства выражения, усиливающие действие вербального языка.
This article focuses on the Cynic strategies of communication and on the problems of interpretation of Cynicism. The author uses Goffman’s theory of self-production, which treats a life as a theatrical performance, and applies some ideas of sociolinguistics and social anthropology to the analysis of Cynicism as a rhetorical practice. The theatricality of Cynical behaviour appears in their careful self-presentation and stylised of their lifestyle, which may be analysed as the exercise of a philosophical rhetoric. The article rests on the assumption that the most significant points of Cynicism are theatricality, use of non-verbal communication and transgressive forms of communication, and preference for such a literary form as chreia. Theatricality can take place in any stylistic register, but the author has concentrated on non-verbal elements in Cynic communication. The author analyses the Cynics’ rhetoric using the modern groundbreaking studies of Donald Lateiner and Robert Branham. The article analyses the Cynic performances, the interactions of Cynics with the public environment, and their use of eating and physical attributes to mark their philosophical position. The author examines Diogen’s use of transgressive non-verbal communication, paying special attention to his conscious use of the body for philosophical purposes. The analysis demonstrates that bodily processes are used as forms of symbolic action, while non-verbal media are designed to strengthen the effect of verbal language.
СТОИЧЕСКИЙ ОПТИМИЗМ МАРКА АВРЕЛИЯ
Authors: КОЧЕРОВ С.Н. 
Published: February 2025

Статья посвящена опровержению представлений о пессимистическом характере мировоззрения Марка Аврелия. Проведенный анализ текста его «Размышлений» показывает, что он представляет диалог стоического мудреца с обычным человеком, в котором Марк Аврелий выступает в обеих ипостасях. Обосновывается, что наставления «философа на троне» имеют позитивный характер и содержат призывы мужественно делать свое дело, направленное на благо Мира и Града, с любовью к людям, не унывая при неудачах и не страшась страданий и смерти. Делается вывод о необходимости комплексного исследования времени, деятельности и «Размышлений» римского императора в сочетании с экзистенциально-феноменологическим анализом его личности.
The article is aimed to confute the belief held about the nature of the worldview of Marcus Aurelius as pessimistic. The analysis of the “Meditations” demonstrates that the text represents a dialogue between a Stoic sage and an ordinary man, Marcus Aurelius being in the guise of both. The article proves that the guidance of the philosopher king is positive in its nature, calling one to fulfill manfully his duties aimed at the welfare of the World and Rome while manifesting love to people and showing no fear of failure, suffering or death. I conclude that a comprehensive analysis of the “Meditations” of the Roman emperor, which contains both the historical and existential background of his personality, is still necessary.