bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mitochondrial protective potential of fucoxanthin in brain disorders
Authors: Ferdous Khondoker Adeba , Jansen Joseph , Amjad Emma , Pray Eliana , Bloch Rebecca , Benoit Alex , Callahan Meredith , Park Han-A 
Published: July 2024

AbstractMitochondrial dysfunction is a common feature of brain disorders. Mitochondria play a central role in oxidative phosphorylation; thus changes in energy metabolism in the brain have been reported in conditions such as Alzheimer’s disease, Parkinson’s disease, and stroke. In addition, mitochondria regulate cellular responses associated with neuronal damage such as the production of reactive oxygen species (ROS), opening of the mitochondrial permeability transition pore (mPTP), and apoptosis. Therefore, interventions that aim to protect mitochondria may be effective against brain disorders. Fucoxanthin is a marine carotenoid that has recently gained recognition for its neuroprotective properties. However, the cellular mechanisms of fucoxanthin in brain disorders, particularly its role in mitochondrial function, have not been thoroughly discussed. This review summarises the current literature on the effects of fucoxanthin on oxidative stress, neuroinflammation, and apoptosis usingin vitroandin vivomodels of brain disorders. We further present the potential mechanisms by which fucoxanthin protects mitochondria, with the objective of developing dietary interventions for a spectrum of brain disorders. Although the studies reviewed are predominantly preclinical studies, they provide important insights into understanding the cellular and molecular functions of fucoxanthin in the brain. Future studies investigating the mechanisms of action and the molecular targets of fucoxanthin are warranted to develop translational approaches to brain disorders.
Evaluation of PRISMA Products Over Snow in the Alps and Antarctica
Authors: Di Mauro B. , Cogliati S. , Bohn N. , Traversa G. , Garzonio R. , Tagliabue G. , Bramati G. , Cremonese E. , Julitta T. , Guanter L. , Kokhanovsky A. , Giardino C. , Panigada C. , Rossini M. , Colombo R. 
Published: July 2024

AbstractPRISMA is a hyperspectral satellite mission launched by the Italian Space Agency (ASI) in April 2019. The mission is designed to collect data at global scale for a variety of applications, including those related to the cryosphere. This study presents an evaluation of PRISMA Level 1 (L1) and Level 2 (L2D) products for different snow conditions. To the aim, PRISMA data were collected at three sites: two in the Western European Alps (Torgnon and Plateau Rosa) and one in East Antarctica (Nansen Ice Shelf). PRISMA data were acquired contemporary to both field measurements and Sentinel‐2 data. Simulated Top of the Atmosphere (TOA) radiance data were then compared to L1 PRISMA and Sentinel‐2 TOA radiance. Bottom Of Atmosphere (BOA) reflectance from PRISMA L2D and Sentinel‐2 L2A data were then evaluated by direct comparison with field data. Both TOA radiance and BOA reflectance PRISMA products were generally in good agreement with field data, showing a Mean Absolute Difference (MAD) lower than 5%. L1 PRISMA TOA radiance products resulted in higher MAD for the site of Torgnon, which features the highest topographic complexity within the investigated areas. In Plateau Rosa we obtained the best comparison between PRISMA L2D reflectance data and in situ measurements, with MAD values lower than 5% for the 400–900 nm range. The Nansen Ice Shelf instead resulted in MAD values <10% between PRISMA L2D and field data, while Sentinel‐2 BOA reflectance showed higher values than other data sources.
Quantifying Seasonal and Diurnal Cycles of Solar‐Induced Fluorescence With a Novel Hyperspectral Imager
Authors: Ruehr Sophie , Gerlein‐Safdi Cynthia , Falco Nicola , Seibert Paul O. , Chou Chunwei , Albert Loren , Keenan Trevor F. 
Published: July 2024

AbstractSolar‐induced fluorescence (SIF) is a proxy of ecosystem photosynthesis that often scales linearly with gross primary productivity (GPP) at the canopy scale. However, the mechanistic relationship between GPP and SIF is still uncertain, especially at smaller temporal and spatial scales. We deployed a ultra‐hyperspectral imager over two grassland sites in California throughout a soil moisture dry down. The imager has high spatial resolution that limits mixed pixels, enabling differentiation between plants and leaves within one scene. We find that imager SIF correlates well with diurnal changes in leaf‐level physiology and gross primary productivity under well‐watered conditions. These relationships deteriorate throughout the dry down event. Our results demonstrate an advancement in SIF imaging with new possibilities in remotely sensing plant canopies from the leaf to the ecosystem. These data can be used to resolve outstanding questions regarding SIF's meaning and usefulness in terrestrial ecosystem monitoring.
Asymmetry in the Diurnal Variation of Land Surface Albedo and Its Impacts on Daily Mean Albedo Estimation
Authors: Han Yuan , Wen Jianguang , Xiao Qing , You Dongqin , Meng Lei , Wu Shengbiao , Hao Dalei , Tang Yong , Chen Xi , Liu Qinhuo , Zhao Congcong 
Published: July 2024

AbstractDaily mean albedo, a crucial variable of the earth radiation budget, is significantly affected by the diurnal variation of land surface albedo (DVLSA). The DVLSA typically exhibits asymmetry, thereby affecting the estimation of the daily mean albedo. However, the asymmetry in the DVLSA is generally ignored in daily mean albedo estimation. In this study, we investigated the influencing factors of the asymmetry in the DVLSA and evaluated its impacts on estimating the daily mean albedo based on field observations and simulated data. Our findings reveal that the asymmetry in the DVLSA varies among land cover types, with forests exhibiting more pronounced asymmetry compared to croplands, grasslands, and bare soil. The diurnal variation of the atmospheric conditions is the primary factor controlling the asymmetry in the DVLSA, with that of land surface conditions being a secondary factor. Neglecting the asymmetry in the DVLSA leads to estimation error in daily mean albedo, particularly pronounced during winter. The relative error of daily mean albedo can exceed 10% when the mean asymmetry index of diffuse irradiance fraction reaches 40%. However, the DVLSA retrieved from the satellite Bidirectional Reflectance Distribution Function product inadequately captures asymmetry, resulting in a relative error of approximately 13.7% in estimating daily mean albedo.
Do Solar Energetic Particle (SEP) Events Influence the Formation of the V0 Layer in the Venusian Ionosphere?
Authors: Tripathi Keshav R. , Imamura T. , Choudhary R. K. , Sánchez–Cano Beatriz , Ambili K. M. 
Published: July 2024

AbstractThis study investigates the potential impact of Solar Energetic Particles (SEPs) on the V0 layer of the Venus ionosphere. Electron density profiles obtained from radio occultation experiments conducted by the Venus Express (VEX) and Akatsuki missions were utilized for this purpose. Background data from the Analyzer of Space Plasma and EneRgetic Atoms (ASPERA‐4) aboard VEX were used to detect SEP events. Additionally, observations from the Space Environment Monitor (SEM) suite onboard the Geostationary Operational Environmental Satellite (GOES) during alignments of Venus, Earth, and the Sun were also considered. Our findings indicate that while SEPs may contribute to the formation of the V0 layer, they are not the main driving force in the Venusian ionosphere.
Solar Energetic Electron Access to the Moon Within the Terrestrial Magnetotail and Shadowing by the Lunar Surface
Authors: Liuzzo Lucas , Poppe Andrew R. , Lee Christina O. , Angelopoulos Vassilis 
Published: July 2024

AbstractWe present measurements of 30–700 keV Solar Energetic Electrons (SEEs) near the Moon when within the terrestrial magnetotail by the Acceleration, Reconnection, Turbulence, and Electrodynamics of the Moon's Interaction with the Sun spacecraft. Despite their detection deep within the tail, the incident flux and spectral shape of these electrons are nearly identical to measurements taken upstream of Earth in the solar wind by the Wind spacecraft; however, their pitch angle distribution is isotropized compared to the more field‐aligned distribution upstream. We illustrate that SEEs initially traveling Earthward precipitate onto the lunar far‐side, generating extended shadows in the cis‐lunar electron distribution. By modeling the dynamics of these electrons, we show that their precipitation patterns on the lunar near‐side are comparatively reduced. The non‐uniform precipitation and accessibility of potentially hazardous electrons to the Moon's surface are highly relevant in the context of astronaut safety during the planned exploration of the lunar environment.
Intra‐Continental Collision of the Tarim Basin and the Northern Tibetan Plateau
Authors: Wang Chun‐Yong , Mooney W. D. , Wang X. , Chang L. , Yao Z. , Lou H. 
Published: July 2024

AbstractThe seismic data recorded at 48 broadband stations on an 1,800‐km‐long linear array have been used to image the deep structure and deformation in the intra‐continental collision between the Tarim Basin and the Northern Tibetan Plateau (NTP). Common Conversion Point (CCP) stacking imaging along the linear array and joint inversion of receiver function and surface wave dispersion defined the crustal and upper mantle structure, indicating that the Tarim block underthrusts the Altyn Tagh Range–Qaidam Basin. Whereas Moho is flattened, the lithospheric mantle beneath the Qaidam Basin has unusually low velocity, which is thought to be the consequence of the delamination in the lower crust and mantle lithosphere. Strong positive phase occurring at depths of 150–200 km on the CCP stacking imaging is likely to be associated to the remnant subducted oceanic lithospheric slab or the underthrusting Tianshan lithospheric slab beneath the collision zone. The removal of the Altyn Tagh Range–Qaidam Basin orogenic root may be due to convection‐driven delamination underneath it and subsequent underthrusting of the Tarim block. The spatial variation of the SKS splitting is manifested as the large‐scale pattern of lithospheric deformation and local abrupt changes, transitioning from pure shear on the NTP to simple shear in the Altyn Tagh Range. A comprehensive analysis of SKS splitting and GPS data reveals a simple shear pattern of vertical coherent deformation in the Altyn Tagh Range and its adjacent areas, which is evidence of the lithospheric shear zones.
The Potential Role of Seasonal Surface Heating on the Chaotic Origins of the El Niño/Southern Oscillation Spring Predictability Barrier
Authors: Yu Dakuan , Zhou Meng , Hang Chaoxun 
Published: July 2024

AbstractThe Spring Predictability Barrier (SPB) phenomenon is characterized by the reduced accuracy of El Niño/Southern Oscillation (ENSO) forecasts during the spring, which substantially limits our ability to predict ENSO events. By investigating the nonlinear dynamic characteristics of ENSO systems simulated by a box model, we found that the strong surface heating process in spring may contribute to the SPB by regulating the different coupling processes between the ocean and atmosphere. Specifically, the intensified springtime surface heating increases the Sea Surface Temperature (SST), further amplifying the thermal damping effect of SST anomalies and reducing the dynamic connection between zonal SST gradient and upwelling process, and finally increasing the chaotic degree of ENSO systems simulated by the box model. The enhanced chaotic degree of ENSO systems leads to a more rapid growth of initial errors in the forecast model in spring, potentially leading to the SPB phenomenon.
Competing Influences of Land Use and Greenhouse Gas Emissions on Mississippi River Basin Hydroclimate Simulated Over the Last Millennium
Authors: Murphy Kelsey , Dee Sylvia , Doss‐Gollin James , Dunne Kieran B. J. , O’Donnell Michelle , Muñoz Samuel 
Published: July 2024

AbstractThe Mississippi River is a vital economic corridor used for generating hydroelectric power, transporting agricultural products, and municipal and industrial water use. Communities, industries, and infrastructure along the Mississippi River face an uncertain future as it grows more susceptible to climate extremes. A key challenge is determining whether Mississippi river discharge will increase or decrease during the 21st century. Because the 20th century record is limited in time, paleoclimate data and model simulations provide enhanced understanding of the basin's hydroclimate response to external forcing. Here, we investigate how anthropogenic forcing in the 20th century shifts the statistics of river discharge compared to a Last Millennium (LM) baseline using simulations from the Community Earth System Model Last Millennium Ensemble. We present evidence that the 20th century exhibits wetter conditions (i.e., increased river discharge) over the basin compared to the pre‐industrial, and that land use/land cover changes have a significant control on the hydroclimatic response. Conversely, while precipitation is projected to increase in the 21st century, the basin is generally drier (i.e., decreased river discharge) compared to the 20th century. Overall, we find that changes in greenhouse gases contribute to a lower risk of extreme discharge and flooding in the basin during the 20th century, while land use changes contribute to increased risk of flooding. The additional climate information afforded by the LM simulations offers an improved understanding of what drove extreme flooding events in the past, which can help inform the development of future regional flood mitigation strategies.
A novel Nav1.5-dependent feedback mechanism driving glycolytic acidification in breast cancer metastasis
Authors: Leslie Theresa K. , Tripp Aurelien , James Andrew D. , Fraser Scott P. , Nelson Michaela , Sajjaboontawee Nattanan , Capatina Alina L. , Toss Michael , Fadhil Wakkas , Salvage Samantha C. , Garcia Mar Arias , Beykou Melina , Rakha Emad , Speirs Valerie , Bakal Chris , Poulogiannis George , Djamgoz Mustafa B. A. , Jackson Antony P. , Matthews Hugh R. , Huang Christopher L-H , Holding Andrew N. , Chawla Sangeeta , Brackenbury William J. 
Published: July 2024

AbstractSolid tumours have abnormally high intracellular [Na+]. The activity of various Na+ channels may underlie this Na+ accumulation. Voltage-gated Na+ channels (VGSCs) have been shown to be functionally active in cancer cell lines, where they promote invasion. However, the mechanisms involved, and clinical relevance, are incompletely understood. Here, we show that protein expression of the Nav1.5 VGSC subtype strongly correlates with increased metastasis and shortened cancer-specific survival in breast cancer patients. In addition, VGSCs are functionally active in patient-derived breast tumour cells, cell lines, and cancer-associated fibroblasts. Knockdown of Nav1.5 in a mouse model of breast cancer suppresses expression of invasion-regulating genes. Nav1.5 activity increases ATP demand and glycolysis in breast cancer cells, likely by upregulating activity of the Na+/K+ ATPase, thus promoting H+ production and extracellular acidification. The pH of murine xenograft tumours is lower at the periphery than in the core, in regions of higher proliferation and lower apoptosis. In turn, acidic extracellular pH elevates persistent Na+ influx through Nav1.5 into breast cancer cells. Together, these findings show positive feedback between extracellular acidification and the movement of Na+ into cancer cells which can facilitate invasion. These results highlight the clinical significance of Nav1.5 activity as a potentiator of breast cancer metastasis and provide further evidence supporting the use of VGSC inhibitors in cancer treatment.
Coding, or non-coding, that is the question
Authors: Poliseno Laura , Lanza Martina , Pandolfi Pier Paolo 
Published: July 2024

AbstractThe advent of high-throughput sequencing uncovered that our genome is pervasively transcribed into RNAs that are seemingly not translated into proteins. It was also found that non-coding RNA transcripts outnumber canonical protein-coding genes. This mindboggling discovery prompted a surge in non-coding RNA research that started unraveling the functional relevance of these new genetic units, shaking the classic definition of “gene”. While the non-coding RNA revolution was still taking place, polysome/ribosome profiling and mass spectrometry analyses revealed that peptides can be translated from non-canonical open reading frames. Therefore, it is becoming evident that the coding vs non-coding dichotomy is way blurrier than anticipated. In this review, we focus on several examples in which the binary classification of coding vs non-coding genes is outdated, since the same bifunctional gene expresses both coding and non-coding products. We discuss the implications of this intricate usage of transcripts in terms of molecular mechanisms of gene expression and biological outputs, which are often concordant, but can also surprisingly be discordant. Finally, we discuss the methodological caveats that are associated with the study of bifunctional genes, and we highlight the opportunities and challenges of therapeutic exploitation of this intricacy towards the development of anticancer therapies.
Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure events
Authors: Heyne Henrike O. , Pajuste Fanny-Dhelia , Wanner Julian , Daniel Onwuchekwa Jennifer I. , Mägi Reedik , Palotie Aarno ,   FinnGen,   Estonian Biobank research team, Kälviainen Reetta , Daly Mark J. 
Published: July 2024

AbstractA diagnosis of epilepsy has significant consequences for an individual but is often challenging in clinical practice. Novel biomarkers are thus greatly needed. Here, we investigated how common genetic factors (epilepsy polygenic risk scores, [PRSs]) influence epilepsy risk in detailed longitudinal electronic health records (EHRs) of > 700k Finns and Estonians. We found that a high genetic generalized epilepsy PRS (PRSGGE) increased risk for genetic generalized epilepsy (GGE) (hazard ratio [HR] 1.73 per PRSGGE standard deviation [SD]) across lifetime and within 10 years after an unspecified seizure event. The effect of PRSGGE was significantly larger on idiopathic generalized epilepsies, in females and for earlier epilepsy onset. Analogously, we found significant but more modest focal epilepsy PRS burden associated with non-acquired focal epilepsy (NAFE). Here, we outline the potential of epilepsy specific PRSs to serve as biomarkers after a first seizure event.
UNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome
Authors: Vogel Antonia , Arnese Renato , Gudino Carrillo Ricardo M. , Sehr Daria , Deszcz Luiza , Bylicki Andrzej , Meinhart Anton , Clausen Tim 
Published: July 2024

AbstractMyosin motors are critical for diverse motility functions, ranging from cytokinesis and endocytosis to muscle contraction. The UNC-45 chaperone controls myosin function mediating the folding, assembly, and degradation of the muscle protein. Here, we analyze the molecular mechanism of UNC-45 as a hub in myosin quality control. We show that UNC-45 forms discrete complexes with folded and unfolded myosin, forwarding them to downstream chaperones and E3 ligases. Structural analysis of a minimal chaperone:substrate complex reveals that UNC-45 binds to a conserved FX3HY motif in the myosin motor domain. Disrupting the observed interface by mutagenesis prevents myosin maturation leading to protein aggregation in vivo. We also show that a mutation in the FX3HY motif linked to the Freeman Sheldon Syndrome impairs UNC-45 assisted folding, reducing the level of functional myosin. These findings demonstrate that a faulty myosin quality control is a critical yet unexplored cause of human myopathies.
Influence of believed AI involvement on the perception of digital medical advice
Authors: Reis Moritz , Reis Florian , Kunde Wilfried 
Published: July 2024

AbstractLarge language models offer novel opportunities to seek digital medical advice. While previous research primarily addressed the performance of such artificial intelligence (AI)-based tools, public perception of these advancements received little attention. In two preregistered studies (n = 2,280), we presented participants with scenarios of patients obtaining medical advice. All participants received identical information, but we manipulated the putative source of this advice (‘AI’, ‘human physician’, ‘human + AI’). ‘AI’- and ‘human + AI’-labeled advice was evaluated as significantly less reliable and less empathetic compared with ‘human’-labeled advice. Moreover, participants indicated lower willingness to follow the advice when AI was believed to be involved in advice generation. Our findings point toward an anti-AI bias when receiving digital medical advice, even when AI is supposedly supervised by physicians. Given the tremendous potential of AI for medicine, elucidating ways to counteract this bias should be an important objective of future research.
The recombinant shingles vaccine is associated with lower risk of dementia
Authors: Taquet Maxime , Dercon Quentin , Todd John A. , Harrison Paul J. 
Published: July 2024

AbstractThere is emerging evidence that the live herpes zoster (shingles) vaccine might protect against dementia. However, the existing data are limited and refer only to the live vaccine, which is now discontinued in the United States and many other countries in favor of a recombinant vaccine. Whether the recombinant shingles vaccine protects against dementia remains unknown. Here we used a natural experiment opportunity created by the rapid transition from the use of live to the use of recombinant vaccines to compare the risk of dementia between vaccine types. We show that the recombinant vaccine is associated with a significantly lower risk of dementia in the 6 years post-vaccination. Specifically, receiving the recombinant vaccine is associated with a 17% increase in diagnosis-free time, translating into 164 additional days lived without a diagnosis of dementia in those subsequently affected. The recombinant shingles vaccine was also associated with lower risks of dementia than were two other vaccines commonly used in older people: influenza and tetanus–diphtheria–pertussis vaccines. The effect was robust across multiple secondary analyses, and was present in both men and women but was greater in women. These findings should stimulate studies investigating the mechanisms underpinning the protection and could facilitate the design of a large-scale randomized control trial to confirm the possible additional benefit of the recombinant shingles vaccine.
Cell stiffening is a label-free indicator of reactive oxygen species-induced intracellular acidification
Authors: Komaragiri Yesaswini , Pires Ricardo Hugo , Spiegler Stefanie , Dau Huy Tung , Biedenweg Doreen , Salas Clara Ortegón , Hossain Md. Faruq , Fregin Bob , Gross Stefan , Gellert Manuela , Lendeckel Uwe , Lillig Christopher , Otto Oliver 
Published: July 2024

AbstractReactive oxygen species (ROS) are important secondary messengers involved in a variety of cellular processes, including activation, proliferation, and differentiation. Hydrogen peroxide (H2O2) is a major ROS typically kept in low nanomolar range that causes cell and tissue damage at supraphysiological concentrations. While ROS have been studied in detail at molecular scale, little is known about their impact on cell mechanical properties as label-free biomarker for stress response. Here, we exposed human myeloid precursor cells, T-lymphoid cells and neutrophils to varying concentrations of H2O2 and show that elevated levels of mitochondrial superoxide are accompanied by an increased Young’s modulus. Mechanical alterations do not originate from global modifications in filamentous actin and microtubules but from cytosolic acidification due to lysosomal degradation. Finally, we demonstrate our findings to be independent of the presence of H2O2 and that stiffening seems to be a general response of cells to stress factors lowering cytosolic pH.