bluuebunny/crossref_metadata_2025_split huggingface dataset:
Atomic force microscopic investigations of transient early-stage bacterial adhesion and antibacterial activity of silver and ceria modified bioactive glass
Authors: Gour Shivani , Mukherjee Abhijit , Balani Kantesh , Dhami Navdeep K. 
Published: July 2024

AbstractBioactive glass 58S (BG58S) is widely recognised for its bioactivity and antibacterial properties, making it a promising material for orthopaedic implant applications. This study investigates the effects of incorporating silver (BG58S-2.5Ag) and cerium oxide (BG58S-5C) into BG58S on early-stage bacterial adhesion and subsequent bacterial growth inhibition. Using a high-intensity ball milling approach, BG58S was modified with 5% cerium oxide (CeO2) and 2.5% silver (Ag) nanoparticles to create homogeneous BG58S-2.5Ag and BG58S-5C nanocomposites. Custom-made biomineral probes were employed to measure the bacterial adhesion within one second of contact with Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus, using Atomic Force Microscopy (AFM). The results demonstrated that BG58S-2.5Ag showed significantly stronger transient adhesion to bacteria compared to BG58S, leading to a more effective long-term antibacterial response. Additionally, it was observed that the antibacterial effect of Ag commenced within one second of contact. These findings indicate a potential correlation between the rate of bond strengthening and cell wall penetration. This study highlights the potential for enhancing the effectiveness of antibacterial implant surfaces for various biomaterial applications.
Graphical abstract
РОЗРОБКА ВЕБ-ДОДАТКУ ДЛЯ ВИВЧЕННЯ ДИСЦИПЛІНИ «ЧИСЕЛЬНІ МЕТОДИ»
Authors: Майдіков І. М. , Корнієнко Ю. К. 
Published: July 2024

Дослідження присвячене розробці та впровадженню веб-додатку для покращення навчання дисципліни «Чисельні методи» у вищих навчальних закладах. Метою дослідження є створення інноваційного навчального середовища, яке допоможе студентам краще засвоювати матеріал та розвивати необхідні навички. У роботі використовується аналіз вимог до програмного забезпечення, який дозволяє зрозуміти потреби користувачів та визначити функціональні вимоги до додатку. Далі проводиться проектування бази даних, що включає у себе структуру та зв’язки між таблицями.
Для розробки веб-додатку використовується архітектура «Модель-Вид-Контролер» (MVC), що дозволяє поліпшити структуру додатку та зробити його більш модульним і зручним у використанні. Використання реляційної бази даних дозволяє забезпечити стійкість до втрати даних та забезпечує швидкий доступ до них. Основною особливістю розробленого додатку є його динамічний контент, який зберігається в базі даних та оновлюється в реальному часі. Це дозволяє студентам отримувати актуальну інформацію та виконувати інтерактивні завдання для закріплення матеріалу.
Використання сучасних технологій, таких як фреймворк Yii2 для розробки веб-додатку, методологія BEM для верстки інтерфейсу та мікророзмітка microdata для покращення SEO-показників, дозволяє створити додаток, який відповідає сучасним вимогам та стандартам.
Аналіз результатів використання веб-додатку показує його високу корисність та можливість використання для покращення навчального процесу та підвищення якості навчання студентів у дисципліні «Чисельні методи». Додаток може бути використаний як у вищих навчальних закладах, так і в інших навчальних установах для покращення процесу навчання та підвищення мотивації студентів до вивчення матеріалу.
Analysis of the incidence of uterine fibroid in Yekaterinburg
Authors: Sevostyanova O. Yu. , Koval M. V. , Chumarnaya T. V. , Belomestnov S. R. , Sevostyanova N. E. , Oboskalova T. A. , Striganova O. D. 
Published: July 2024

Background. Uterine fibroid (UF) is a benign tumor of the myometrium and is considered as one of the criteria for the state of women’s reproductive health. Objective information about the incidence of UF in a modern megalopolis allows us to assess the level of health of the female population, characterize the availability and quality of medical care, and plan its development.Aim. To analyze the incidence and prevalence of UF according to the data of medical organizations in Yekaterinburg in 2016–2022.Materials and methods. An epidemiological study of the incidence and prevalence of the adult female population of the city of Yekaterinburg in 2016–2022 was conducted. For the analysis, we used Form No. 12 of the Federal Statistical Observation of Medical Organizations located in the city. The incidence rates were calculated for the average annual female population aged 18 years and over, expressed in 0/0000. Absolute growth (decrease), growth rate (decrease), growth rate (decrease), average growth rate (decrease) were studied. The long-term dynamics of the indicators was determined using the average growth rate.Results. The incidence of UF was 130.890/0000, and the prevalence was 735.800/0000 in 2016. During the pre-pandemic period, the indicators increased significantly in 2019 compared to the baseline year 2016 (р < 0.001). The incidence increased by 1.96 times, the prevalence – by 1.39 times. The indicators decreased to the level of 2016 during the pandemic of new coronavirus infection (2020–2022) (р >0.05).Conclusion. The obtained dynamics of incidence and prevalence of UF in the population of women in a modern megalopolis is considered as a criterion for the state of women’s health, accessibility and quality of preventive and planned medical care for gynecological patients. The results of the study are recommended for planning medical care for women and can form the basis for continuing epidemiological studies.
Cerita Anak Mamlakah Al-’Adl Karya Ismail Abdul Fatah: Analisis Struktural
Authors: Sholikhah Istatik Hidayatus , Huda Ibnu Samsul 
Published: July 2024

Penelitian ini bertujuan untuk menjelaskan dan mendiskripsikan unsur-unsur intrinsik yang membangun cerita anak Mamlakah Al-’adl karya Ismail Abdul Fatah beserta keterkaitan antar unsurnya. Metode yang digunakan dalam penelitian ini ialah kajian struktural. Teknik pengumpulan data dilakukan dengan teknik dokumentasi. Hasil penelitian menunjukkan bahwa: (a) tema mayor dalam cerita ini adalah kebaikan yang membawa keberkahan, yang dapat melahirkan kebaikan-kebaikan yang lain, adapun tema minornya adalah tanggung jawab, kemiskinan, tolong menolong, keserakahan, dan keajaiban. (b) pada cerita ini menggunakan alur campuran. (c) tokoh utamanya adalah Mansur, sedangkan tokoh tambahannya adalah Syekh Mas’ud, Kahramanah, Murjanah, Bahiyyah, Bahlul, Induk Burung, dan Burung Yasmin. (d) latar tempatnya berada di gubuk, tepi sungai, pinggiran hutan, rumah Bahiyyah, hutan, tengah jalan, tempat kuno, dan Istana dengan berlatar waktu pada pagi hari, siang hari, sore hari, dan malam hari, serta berlatar sosial tentang tentang di suatu kerajaan yang dahulunya dipimpin oleh seorang raja yang adil, hingga suatu hari kerajaan tersebut menghilang karena perbuatan orang-orang jahat yang telah merebut kekuasaan kerajaan secara paksa (e) sudut pandangnya adalah orang ketiga. Pada unsur-unsur intrinsik dalam cerpen ini memiliki keterkaitan yang padu antara satu dengan yang lainnya dalam membangun cerita.
Inovasi Media Lava Pijar dalam Meningkatkan Literasi Sains Anak Usia 5-6 Tahun Siswa Bustanul Athfal
Authors: Karimah Nikmatul , Mas’ula Siti 
Published: July 2024

Inovasi pembelajaran bertujuan untuk mengembangkan media pembelajaran sains berupa lava pijar untuk meningkatkan literasi sains pada anak usia dini. Berdasarkan laporan PISA (Programme for International Student Assessment) dari 80 negara di tahun 2018, indikator literasi sains Indonesia memiliki rata-rata 396 dari 457,6, skor tersebut menurun dari tes PISA 2015, saat itu memiliki rata-rata 403 dari 467,0. Dari data tersebut diperlukan adanya pembaharuan dalam hal pembelajaran di Indonesia, salah satunya dengan adanya inovasi media pembelajaran dikarenakan media memegang peranan penting dalam proses pembelajaran. Subjek penelitiannya adalah anak berusia 5-6 tahun dengan jumlah 48 anak. Metode yang digunakan dalam penelitian ini, yaitu metode pengembangan Borg and Gall, dengan tahapan yang terdiri dari uji validasi, pengembangan media dan menguji keefektifan media dalam mencapai tujuan untuk meningkatkan literasi sains anak usia 5-6 tahun. Berdasarkan hasil uji coba, media lava pijar memenuhi standarisasi, yaitu efektif, efisien dan berkualitas. Hasil penelitian menunjukkan, bahwa kelompok B1 mengalami peningkatan literasi sains sebesar 83,3 persen setelah adanya pembelajaran dengan media lava pijar, sedangkan kelompok B2 hanya mengalami peningkatan sebesar 20,8 persen setelah adanya pembelajaran tanpa media. Sehingga dapat disimpulkan bahwa media lava pijar sangat layak digunakan untuk meningkatkan literasi sains anak usia dini.
Oxidative stress and its correlation with glycated haemoglobin in patients of type 2 diabetes mellitus
Authors: Kaur Sukhraj 
Published: July 2024

Background: Type 2 diabetes mellitus (T2DM) has a heavy disease burden and is one of the leading causes of death worldwide. Oxidative stress leads to the generation of inflammatory mediators and reactive oxygen species, which results in an inflammatory state, which plays a key role in the pathogenesis of diabetes and its complications. We aimed to correlate the levels of Glycated Haemoglobin with Oxidative Stress.
Methods: This study included 200 subjects, 100 were type 2 diabetics and 100 healthy non-diabetic individuals. All the individuals were subjected to analysis of Fasting Plasma Glucose, Glycosylated Haemoglobin, Malondialdehyde, Superoxide Dismutase, Glutathione, Catalase, Uric Acid and Ascorbic Acid. The data thus generated was analyzed Statistically using the student ‘t’ test. ANOVA for comparison of mean in more than two groups. Pearson’s coefficient of correlation was used to calculate the correlation between different parameters. p <0.05 was considered statistically significant.
Results: The results showed that as the Glycated Hb increased, the levels of FBS, MDA, Uric acid increased and Serum SOD, Glutathione, Catalase, and Ascorbic acid levels decreased this change was statistically significant (p<0.05). A positive significant correlation between HbA1c, and fasting blood Glucose, MDA, Uric Acid. SOD, Catalase, Ascorbic Acid and Glutathione showed a negative correlation with glycosylated Haemoglobin.
Conclusions: It is hereby concluded that when glycated Hb increases the natural antioxidants that are SOD, catalase, and glutathione decrease to combat the increased formation of ROS. Serum MDA, increased with increased glycated Hb and shows a positive correlation, indicating increasing lipid peroxidation.
Assessment of knowledge and utilization of antenatal care services among tribal women of Palakkad district, Kerala: a cross-sectional study
Authors: V. P. Renu , Savatagi Shivanand B. , A. Nabil , A. Sonu Soman , P. K. Akshay 
Published: July 2024

Background: Nearly 800 women die out of preventable causes associated with pregnancy and childbirth worldwide every day, with low and middle-income countries contributing approximately 90% of the mortality. The majority of pregnancy-related deaths are preventable with the provisioning of cost-effective services like antenatal care (ANC). Despite Kerala having a good human development index compared to other states in India, marginalized groups like Dalit, Adivasi, and fisher folks are still behind the development process, including the utilization of ANC services. This study assessed the knowledge and utilization of ANC services among tribals in Kerala, India.
Methods: A cross-sectional study was conducted among 45 tribal women of Palakkad district, Kerala, who registered for ANC and delivered child. Convenient sampling was used to select study participants. Descriptive statistics were used to obtain frequency and percentage. The chi-square test was carried out to see the association between identified variables.
Results: Among 45 participants, 28.89% fell under the adequate ANC utilization. 64.46% did early ANC registration, 73.3% visited ANC more than four times, 75.56% completed the 2 tetanus toxoid (TT) injections, and 66.67% consumed more than 100 iron-folic acid tablets. About 73.3% of participants knew the importance of immunizing children against vaccine-preventable diseases.
Conclusions: Even in an egalitarian state like Kerala with high literacy, ANC service utilization among tribal communities is still below 70%. The issue is multifaceted and requires a more nuanced approach. The health system must adopt comprehensive, context-specific, and community-based approaches.
Penerapan PLTS Sebagai Sumber Energi Listrik Untuk UMKM Kerupuk Wanita Tani di Desa Tanjung Karawang
Authors: Satria Dika , Asmara Putri Clara Virnanda , Nasta Latu Mery Athonia , Bangun Elisa Athonia , Sutiyana Agus 
Published: July 2024

Pengabdian kepada masyarakat ini bertujuan untuk menerapkan sistem fotovoltaik surya (PLTS) sebagai sumber energi listrik yang andal dan berkelanjutan bagi Usaha Mikro, Kecil, dan Menengah (UMKM) Kerupuk Wanita Tani di Desa Tanjung Karawang. Metode yang digunakan dalam kegiatan ini adalah perencanaan pelaksanaan dan pelatihan pemasangan PLTS. Hasil dari kegiatan ini menunjukkan bahwa UMKM Kerupuk Wanita Tani telah memiliki sistem PLTS yang dapat memenuhi kebutuhan energi listriknya secara mandiri. Dampak dari kegiatan ini adalah meningkatkan produktivitas UMKM Wanita Tani Desa Tanjung, memberikan akses listrik kepada PAUD Desa Tanjung dan penerangan jalan warga. Selain itu, Pemasangan PLTS dapat meningkatkan pemahaman masyarakat untuk ikut serta mengimplementasikan PLTS sebagai desa mandiri energi dalam upaya mengurangi gas emisi rumah kaca.
HDAC8 controls hypoxia-induced conversion of sensory Schwann cells into repair cells
Authors: Hertzog Nadège , Duman Mert , Bochud Maëlle , Brügger-Verdon Valérie , Gerhards Maren , Schön Felicia , Dorndecker Franka , Fledrich Robert , Stassart Ruth , Sankar Devanarayanan , Dengjel Joern , López Sofía Raigón , Jacob Claire 
Published: July 2024

Abstract

Schwann cells (SCs), the myelinating glia of the peripheral nervous system (PNS), react to a PNS injury by converting into repair cells that foster axonal regrowth, and then remyelinate or re-ensheath regenerated axons, thereby ensuring functional recovery. The efficiency of this mechanism depends however on the time needed for axons to regrow. Here, we show that ablation of histone deacetylase 8 (HDAC8) in SCs accelerates the regrowth of sensory axons and sensory function recovery. We found that HDAC8 is specifically expressed in sensory SCs and regulates the E3 ubiquitin ligase TRAF7, which destabilizes hypoxia-inducible factor 1-alpha (HIF1a) and counteracts the phosphorylation and upregulation of c-Jun, a major inducer of the repair SC phenotype. Our study demonstrates that this phenotype switch is regulated by different mechanisms in sensory and motor SCs and is accelerated by HDAC8 downregulation, which promotes sensory axon regeneration and sensory function recovery.
Isolated During Adolescence: Long-term Impact on Social Behavior, Pain Sensitivity, and the Oxytocin System in Male and Female Rats
Authors: Graf Akseli , Hansson Anita C , Spanagel Rainer 
Published: July 2024

Abstract

Background: Adolescent social isolation (ASI) has profound long-term effects on behavioral and neural development. Despite this, the specific long-term impact of ASI during different adolescent stages and across sexes remain underexplored.
Methods: Our study addresses this gap by examining the effects of early- and late- adolescent social isolation on both male and female rats. Rats were either isolated or group-housed starting from PD 21 (early) or PD 42 (late) for three weeks and then rehoused into groups. In adulthood (PD 90), rats underwent a battery of tests: elevated plus-maze, open field, novel object recognition, social interaction and social recognition memory and hotplate tests. Finally, we analyzed oxytocin receptor binding in several regions in the brains of a second cohort of rats.
Results: Both, male and female rats from the late adolescent social isolation (LASI) groups spent significantly less time interacting in the social interaction test. Additionally, we observed a general decrease in social recognition memory regardless of sex. Both male ASI groups demonstrated heightened thermal pain sensitivity, while the opposite was observed in early adolescent social isolation (EASI) female rats. In the brain, we observed changes in oxytocin receptor (OTR) binding in the paraventricular nucleus of the hypothalamus (PVN) and paraventricular nucleus of the thalamus (PVT) and central amygdala (CeA) with the largest changes in EASI and LASI female rats.
Conclusion: Our model demonstrates long-lasting alterations on the behavior and oxytocin receptor binding levels following ASI providing insights into the long-term effects of ASI in a time- and sex-specific manner.
Re-crystallization in Glass Supported MgO Quantum Dot Doped PMMA Film: Effect of Annealing Hours and Composition
Authors: Singh Satya Pal , Singh Archana , Vishwakarma Suraj 
Published: July 2024

Abstract

We have blended MgO nanoparticles with Poly (methyl methacrylate) thin films by solution casting method. MgO nanoparticles are doped in 5 wt %, 10 wt % and 15 wt % in PMMA film, and annealed for 02, 04, 06, 08, 10, 12, 14, 20, 24 and 28 hours at 130 0C. We have comprehensively investigated the molecular scale re-structuring and morphological evolution of the composite films and have accounted reasons based on the observations made on chemical bonding, crystallinity, bandgap, Urbach energy, and fluorescence and Raman spectra. We observe that the film loses its overall crytallinity in initial stages of annealing which latter improves slightly owing to the temperature induced limited diffusion of MgO QDs (sizes in the range of 7.0603 nm-9.5647 nm). The limited diffusion of MgO QDs allows for the formation of larger clusters, which in turn affects the local crystallinity of the composite films. We report local scale re-crystallization. We have discussed the role of competing forces. Evolution of nano-micro scale structures inside the films are governed by the reconciliation between inter and intra-molecular forces. The temperature of the film plays an intermediate role facilitating the whole process. To get molecular scale insights, we have estimated crystallinity, bandgap and Urbach energy of the pure and hybrid films. Dispersed MgO nanoparticles diffuse locally and nucleate to form larger spherical clusters. Anchoring of MgO nanoparticles on PMMA surface and vice-versa appears to provide thermal stability and mechanical strength to the nanocomposite films, as MgO nanoparticle doped PMMA film appears to form nano-micron-size particulates of PMMA. Contradictory to that, the overall crystallinity of the hybrid film drastically falls as the formation of boundaries, interfaces and voids overwhelms the whole process. Formation of larger nano-aggregates at latter stages of annealing slightly improves the crystallinity of the film. Estimation of bandgap and Urbach energy calculation confirm for the same. The micro-level phenomenological understanding of the diffusion process of nanodots in solid film atmosphere is technically important for ensuring the sustainability of such nanocomposites, which goes through a heating process.
CHAM: A Multi-Population Hybrid Metaheuristic Algorithm for Optimal Controller Placement in Multi-Controller Software-Defined Networks
Authors: Tasouji Ali Sabouhi , Solouk Vahid , Barshandeh Saeid 
Published: July 2024

Abstract

Software-defined Networks (SDNs) have become prevalent because of their augmentation in state-of-the-art networking technologies regarding scalability and deployment cost. While SDNs incur in actively reducing initial network design and implementation expenses, they leave significant challenges that may influence the overall performance. The Controller Placement Problem (CPP) is among the primary issues with considerable drawbacks on QoS parameters. However, CPP is known as an NP-Hard problem for which several approaches have been reported that introduce solutions. Due to the extreme volatility of the SDN size in terms of the number of switches and controllers, the CPP is deemed to compel extensive studies for a reliable solution. The current paper introduces a metaheuristic algorithm to achieve a solution for controller replacement. Accordingly, the CPP is formulated as an optimization problem, and an influential chaotic-based multi-population hybrid method (CHAM) is designed to find a solution. The proposed method encompasses two distinct algorithms: artificial ecosystem-based optimization (AEO) and marine predators’ algorithm (MPA). These discrete algorithms are then merged using a multi-population strategy. Next, a local search mechanism is introduced to exploit the existing solutions. As the next step, a chaotic neighborhood search mechanism is also provided in the CHAM to search for promising areas in the subpopulations. Finally, a migration procedure is presented to convey solutions between subpopulations. For evaluation purposes, CHAM was employed in ten real-world SDN networks with different sizes and configurations, and the results are compared with nine existing approaches. The experimental results indicate that the proposed method performs affordably well compared to the existing solutions. For example, the proposed method improves network performance by 25% by creating conditions close to related works.
From Node to Network: Weaving A Global Perspective on Efficacy and Costs of Non-Pharmaceutical Interventions
Authors: Xu Chong , Kumar Sameer , Yang Muer , Ghildayal Nidhi , Chandra Charu 
Published: July 2024

Abstract

Non-pharmaceutical intervention (NPI) policies, ranging from mild intervention to total isolation, were implemented during the COVID-19 pandemic across the globe. We adopt a systematic approach to guide policymakers in deployment of NPI policies to mitigate the pandemic's effects while maintaining a proper balance on their social and economic impacts. The optimal timings to enact and to end a policy depend both on the strictness of the policy and the transmissibility of the virus. Our results show that the strict policy is not always the most effective to mitigate the disease, while other modest NPIs can function better especially when the virus is highly transmissible. If an NPI can only be applied for a limited period due to economic and social constraints, it is always suboptimal to implement it at the pandemic's onset.
Improving the Care Outcomes of Traumatic Enucleation with Artificial Eye Implant: a case report
Authors: Adeleke Olumide , Aina Akinsola , Awe Oluseun , Aina ifeoluwasemilojo 
Published: July 2024

Abstract

Traumatic enucleation is a rare consequence of high-impact trauma. It is a severe injury leading to permanent loss of vision. One of the most common causes of traumatic globe enucleation is automobile accidents. This damage may have a severe effect on the patient's physical and mental health. Apart from the permanent loss of vision in the affected eye with traumatic enucleation, some complications, including pseudoptosis, orbital infection, hemorrhages, and scarring can occur. Traumatic enucleation may also be complicated by psychological problems like stigma, depression, anxiety, and post-traumatic stress disorder. However, following enucleation, patients might be given a prosthetic eye to help them appear like normal eyes once more and prevent psychological problems. The goal of this case report is to highlight the potential occurrence of traumatic enucleation following a road traffic accident, as well as to describe the appropriate management of patients who present with this condition including the role of artificial eye implants in the management of such patients.