bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delay in the acquisition of Differential Object Marking by Spanish monolingual and bilingual teenagers
Authors: Guijarro-Fuentes Pedro , Pires Acrisio , Nediger Will 
Published: September 2015

Aims and Objectives/Purpose/Research Questions: This study investigated the acquisition of Spanish Differential Object Marking (DOM) by bilingual and monolingual Spanish teenagers, evaluating to which extent their knowledge of DOM can be explained by different theories of acquisition. Design/Methodology/Approach: Two experiments with bilingual and monolingual Spanish teenagers (ages 10 to 15) were conducted. The experiments included an Elicited Production Completion Task, in which a space was to either be filled with an object marker or left blank, and a Context-Matching Acceptability Judgment Task. Data and Analysis: 54 subjects (44 bilinguals and 10 monolinguals) were tested. For both tasks, there were 6 conditions testing different syntactic–semantic features that trigger DOM (test items n = 42 in each task). The data were analysed with linear regressions and repeated measures analyses of variance. Findings/Conclusions: This study’s results show that bilingual teenagers do not demonstrate significant differences from age-matched monolinguals in their competence regarding the syntactic–semantic properties of DOM. Both groups are below ceiling in showing evidence of knowledge about all the syntactic–semantic features involved in DOM, indicating the possibility of a significant delay beyond childhood in their acquisition. Originality: There are few previous studies on the acquisition of DOM, and none which consider the full range of features and specific population considered here. Work by Montrul focuses on the animacy feature, while Guijarro-Fuentes considers the full range of features, but for adult L2 learners of Spanish. Significance/Implications: This study shows that the Interface Vulnerability Hypothesis, the Feature Reassembly Hypothesis, the Full Access/Full Transfer Hypothesis and the Interpretability Hypothesis have limitations in explaining its results. Instead, a feature-based approach is proposed in which the specification of features beyond animacy raises difficulties for the acquisition of DOM until late childhood.
Mammographic density and histopathologic characteristics of screen-detected tumors in the Norwegian Breast Cancer Screening Program
Authors: Moshina Nataliia , Ursin Giske , Hoff Solveig Roth , Akslen Lars A , Roman Marta , Sebuødegård Sofie , Hofvind Solveig 
Published: September 2015

Background High mammographic density might mask breast tumors, resulting in delayed diagnosis or missed cancers. Purpose To investigate the association between mammographic density and histopathologic tumor characteristics (histologic type, size, grade, and lymph node status) among women screened in the Norwegian Breast Cancer Screening Program. Material and Methods Information about 1760 screen-detected ductal carcinoma in situ (DCIS) and 7366 invasive breast cancers diagnosed among women aged 50–69 years, 1996–2010, was analyzed. The screening mammograms were classified subjectively according to the amount of fibroglandular tissue into fatty, medium dense, and dense by breast radiologists. Chi-square test was used to compare the distribution of tumor characteristics by mammographic density. Odds ratio (OR) of tumor characteristics by density was estimated by means of logistic regression, adjusting for screening mode (screen-film and full-field digital mammography), and age. Results Mean and median tumor size of invasive breast cancers was 13.8 and 12 mm, respectively, for women with fatty breasts, and 16.2 and 14 mm for those with dense breasts. Lymph node positive tumors were identified among 20.6% of women with fatty breasts compared with 27.2% of those with dense breasts ( P < 0.001). The proportion of DCIS was significantly lower for women with fatty (15.8%) compared with dense breasts (22.0%). Women with dense breasts had an increased risk of large (OR, 1.44; 95% CI, 1.18–1.73) and lymph node positive tumors (OR, 1.26; 95% CI, 1.05–1.51) compared with women with fatty and medium dense breasts. Conclusion High mammographic density was positively associated with tumor size and lymph node positive tumors.
Variant Profiling of Candidate Genes in Pancreatic Ductal Adenocarcinoma
Authors: Huang Jiaqi , Löhr Johannes-Matthias , Nilsson Magnus , Segersvärd Ralf , Matsson Hans , Verbeke Caroline , Heuchel Rainer , Kere Juha , Iafrate A John , Zheng Zongli , Ye Weimin 
Published: September 2015

AbstractBACKGROUNDPancreatic ductal adenocarcinoma (PDAC) has a poor prognosis. Variant profiling is crucial for developing personalized treatment and elucidating the etiology of this disease.METHODSPatients with PDAC undergoing surgery from 2007 to 2012 (n = 73) were followed from diagnosis until death or the end of the study. We applied an anchored multiplex PCR (AMP)-based next-generation sequencing (NGS) method to a panel of 65 selected genes and assessed analytical performance by sequencing a quantitative multiplex DNA reference standard. In clinical PDAC samples, detection of low-level KRAS (Kirsten rat sarcoma viral oncogene homolog) mutations was validated by allele-specific PCR and digital PCR. We compared overall survival of patients according to KRAS mutation status by log-rank test and applied logistic regression to evaluate the association between smoking and tumor variant types.RESULTSThe AMP-based NGS method could detect variants with allele frequencies as low as 1% given sufficient sequencing depth (&gt;1500×). Low-frequency KRAS G12 mutations (allele frequency 1%–5%) were all confirmed by allele-specific PCR and digital PCR. The most prevalent genetic alterations were in KRAS (78% of patients), TP53 (tumor protein p53) (25%), and SMAD4 (SMAD family member 4) (8%). Overall survival in T3-stage PDAC patients differed among KRAS mutation subtypes (P = 0.019). Transversion variants were more common in ever-smokers than in never-smokers (odds ratio 5.7; 95% CI 1.2–27.8).CONCLUSIONSThe AMP-based NGS method is applicable for profiling tumor variants. Using this approach, we demonstrated that in PDAC patients, KRAS mutant subtype G12V is associated with poorer survival, and that transversion variants are more common among smokers.
Michelangelo Antonioni and Atom Egoyan: Contaminating identities
Authors: Baso Giulia 
Published: September 2015

Abstract
This article aims to bring together two major directors, Michelangelo Antonioni and Atom Egoyan, in a way that sheds new light upon their oeuvres. It is inspired by an unrealized venture, a screen adaptation that the two auteurs were supposed to film together in the late 1990s, provisionally entitled Just to Be Together. Focusing on what came before this suspended artistic collaboration, the present study proposes a comparative reading of Professione: Reporter/The Passenger and Next of Kin, developed through the theoretical work of Rosi Braidotti and Richard Dyer. It attempts to rethink the ‘auteur of modernist alienation’ from the perspective of contemporary theoretical frameworks, and beyond the specific context of Italian film culture. At the same time, it argues for a repositioning of Egoyan’s debut feature film in a non-strictly diasporic context, entering debates around accented and transnational models in film studies.
Music and migration: Transgenerational crossovers in La vera leggenda di Tony Vilar and Di madre in figlia
Authors: Clò Clarissa 
Published: September 2015

Abstract
In this article I discuss Giuseppe Gagliardi’s La vera leggenda di Tony Vilar/The True Legend of Tony Vilar (2006) and Andrea Zambelli’s Di madre in figlia/ From Mother to Daughter (2008) as crossover and transnational documentaries engaging with both internal and international histories of Italian migration that also illuminate Italy’s current postcolonial condition. I claim that both films encourage a reflection on the ability of music and film to travel across national boundaries, engender cultural collaborations and contaminations, and create meaning and identification for different communities and generations. The directors’ and protagonists’ deliberate emphasis on performance and performativity in the construction of the characters on and off stage and the numerous self-reflexive and meta-cinematic elements of the two films, from mockumentary to found footage, disrupt the perceived objective truths often assigned to documentary and point towards more productive ways of representing and interpreting reality.
Simultaneous Estimation of Additive and Mutational Genetic Variance in an Outbred Population of Drosophila serrata
Authors: McGuigan Katrina , Aguirre J David , Blows Mark W 
Published: September 2015

Abstract
How new mutations contribute to genetic variation is a key question in biology. Although the evolutionary fate of an allele is largely determined by its heterozygous effect, most estimates of mutational variance and mutational effects derive from highly inbred lines, where new mutations are present in homozygous form. In an attempt to overcome this limitation, middle-class neighborhood (MCN) experiments have been used to assess the fitness effect of new mutations in heterozygous form. However, because MCN populations harbor substantial standing genetic variance, estimates of mutational variance have not typically been available from such experiments. Here we employ a modification of the animal model to analyze data from 22 generations of Drosophila serrata bred in an MCN design. Mutational heritability, measured for eight cuticular hydrocarbons, 10 wing-shape traits, and wing size in this outbred genetic background, ranged from 0.0006 to 0.006 (with one exception), a similar range to that reported from studies employing inbred lines. Simultaneously partitioning the additive and mutational variance in the same outbred population allowed us to quantitatively test the ability of mutation-selection balance models to explain the observed levels of additive and mutational genetic variance. The Gaussian allelic approximation and house-of-cards models, which assume real stabilizing selection on single traits, both overestimated the genetic variance maintained at equilibrium, but the house-of-cards model was a closer fit to the data. This analytical approach has the potential to be broadly applied, expanding our understanding of the dynamics of genetic variance in natural populations.
A review of the genera and subgenera of Oxaeinae (Hymenoptera: Andrenidae)
Authors: Engel Michael S. 
Published: September 2015

The supraspecific groups of the bee subfamily Oxaeinae are briefly reviewed and a revised classification proposed. The following new groups are established: Mesoxaea (Heteroxaea) Engel, new subgenus; Oxaea (Rhodoxaea) Engel, new subgenus; and Oxaea (Percnoxaea) Engel, new subgenus. A key to the genera and subgenera of Oxaeinae is provided.
Comparison of Ethical Dilemmas Across Public and Private Sectors in Rehabilitation Counseling Practice
Authors: Beveridge Scott , Garcia Jorge , Siblo Matt 
Published: September 2015

Purpose:To examine the nature of ethical dilemmas most frequently reported by rehabilitation counselors in the private and public sectors and determine if significant differences exist in how practitioners experience ethical dilemmas in these two settings.Method:A mixed-methods internet-based survey design was utilized and included descriptive, qualitative, and quantitative approaches on a sample of rehabilitation counselors (N= 141) via an instrument created by the researchers.Results:The results indicate that there are clear differences between both the nature and frequency of ethical dilemmas encountered by practitioners in the private and public sectors of rehabilitation counseling. Findings indicate that there are significant differences not only in the frequency and importance each group attributes to ethical dilemmas but also in the types of ethical dilemmas experienced.Conclusion:Rehabilitation counselors in the private and public sectors practice in different environments (with varied laws, rehabilitation goals, duration of services), and minimal consideration has been given to the diversity of ethical dilemmas that these practitioners encounter in their professional roles. The inclusion of Section F in the 2010 CRCC Code of Ethics was the rehabilitation counseling field’s first attempt to address the differing nature of ethical dilemmas faced by private rehabilitation counselors in their practice. Further study is warranted to examine the dynamics that underlie the ethical decision-making process as well exploring the differences between these two settings.
Association of Interferon-Gamma Inducible Protein 10 Polymorphism with Treatment Response to Pegylated Interferon in HBeAg-Positive Chronic Hepatitis B
Authors: Limothai Umaporn , Chuaypen Natthaya , Khlaiphuengsin Apichaya , Posuwan Nawarat , Wasitthankasem Rujipat , Poovorawan Yong , Tangkijvanich Pisit 
Published: September 2015

Background Interferon-gamma inducible protein 10 (IP-10) plays an important role in the clinical outcome of chronic hepatitis B (CHB). This study aimed to investigate the association between single nucleotide polymorphisms (SNPs) G-201A of the IP-10 gene and treatment response to pegylated interferon (PEG-IFN) in patients with hepatitis B e antigen (HBeAg)-positive CHB. Methods We retrospectively analysed data of patients with HBeAg-positive CHB treated with PEG-IFN for 48 weeks. Virological response (VR) was defined as HBeAg clearance and HBV DNA <2,000 IU/ml at 24 weeks post-treatment. The SNPs G-201A, IFNL3 (rs12979860) and HLA-DPA1 (rs3077) were assessed. Results Among 107 patients, VR was achieved in 45 (42.1%) patients. Hepatitis B surface antigen (HBsAg) clearance and decline (<100 IU/ml) were observed in 10 (9.3%) and 22 (20.6%) patients, respectively. The distribution of GG, GA and AA genotypes of G-201A was 76.6%, 19.6% and 3.7%, respectively. Patients with GG genotype, compared to those with non-GG genotype, achieved higher VR rate (48.8% versus 19.2%; P=0.011), decreased HBsAg (25.6% versus 4.0%; P=0.019), and demonstrated a trend in HBsAg clearance (11.0% versus 4%; P=0.294). Patients with GG genotype had more rapid HBsAg decline and higher baseline serum IP-10 levels than those with non-GG genotype (432.2 ±339.0 versus 257.3 ±145.7 pg/ml; P=0.028). SNPs rs12979860 and rs3077 were not associated with VR. Logistic regression analysis suggested that SNP G-201A was an independent predictor of VR (odds ratio 3.81, 95% CI 1.31, 11.12; P=0.014). Conclusions Data from this study demonstrated for the first time that IP-10 polymorphism is independently associated with treatment response to PEG-IFN in patients with HBeAg-positive CHB.
Les critères de choix d’une destination par la segmentation des expériences de consommation des touristes : une application aux stations de ski
Authors: Guallino Gabriel , Salvador Marielle 
Published: September 2015

La France possède plus de 400 stations de ski, et se classe régulièrement première destination touristique mondiale. Cependant, les consommateurs de sports d’hiver restent mal connus, et les études quantitatives validant une typologie de consommateurs sont rares. Cet article propose de répondre à cet enjeu. Après avoir interrogé 1843 touristes selon 28 critères de l’expérience de consommation recherchée en station de ski, quatre dimensions principales sont extraites : la recherche de sensations, l’hédonisme et l’image, le territoire et le patrimoine, et le service garanti. À partir de ces quatre dimensions, une typologie a été réalisée. Cinq groupes de consommateurs se dégagent : les touristes à la recherche de multi-expériences, les grands-parents, les touristes en quête de nature, les sportifs et les touristes passifs.
Transfert des contrats de travail en cas de transmission d’entreprise : une analyse économique du droit d’opposition du salarié
Authors: Thepot-Olagne Cécile 
Published: September 2015

En cas de transmission d’entreprise, certains auteurs estiment que les salariés devraient bénéficier d’un « droit d’opposition au transfert » c’est-à-dire de la possibilité de refuser de travailler pour le nouvel employeur, tout en jouissant de garanties financières. A priori favorable aux salariés, une tel le idée est en réa lité contre-productive. Elle aggraverait l’aléa moral des transferts d’entreprises et risquerait de faire échec à certains d’entre eux. Cela est préjudiciable pour l’ensemble des parties prenantes, salariés compris.
La typification en tant que « modèle » expérientiel
Authors: Butnaru Denisa 
Published: September 2015

Le concept de typification a une longue histoire en sociologie de la connaissance et il représente un des concepts majeurs de la phénoménologie sociale inaugurée par Alfred Schütz. Le questionner sous son aspect de modèle expérientiel permet une reconsidération à la fois de la sphère subjective ainsi que du rapport que la typification entretient à l’altérité. Le but de cet article est de problématiser trois aspects fondamentaux du concept de typification, notamment épistémologique, praxéologique et enfin ontologique, afin de montrer ses propriétés de « modèle » expérientiel.
Accurate water‐table depth estimation using seismic refraction in areas of rapidly varying subsurface conditions
Authors: Desper Douglas B. , Link Curtis A. , Nelson Paul N. 
Published: September 2015

ABSTRACTA common approach for estimating water‐table depth simply and reliably is using seismic refraction. Typical layered solutions from seismic refraction are successful in areas where the water table does not fluctuate rapidly. However, there are many areas around the world where water tables rise and fall rapidly in response to intense rainfall events, especially in tropical and semi‐arid regions. These areas are frequently heavily populated, and the shallow unconfined aquifers, used for drinking water and irrigation, are under increasing threat of overexploitation and pollution. To help mitigate these concerns, a reliable method to accurately determine water‐table depth in these environments is required. We present a unique analysis method based on a calculated reference refraction velocity that gives not only accurate predictions of water‐table depth for cases of rapidly fluctuating water tables but also accurate predictions of largest historical recorded depth to water.Data used came from a series of 60 refraction surveys carried out at 15 locations with monitoring bores in a tropical area. In a time‐lapse approach, four surveys were performed at each of the bore locations over a nine‐week period during both wet and dry conditions. Using a typical forward/reverse profile approach, we first calculate forward and reverse velocities. These layer velocities are then averaged using a scheme based on moisture conditions to give a reference velocity. Finally, the predicted depth for the water table is determined by identifying the depth at which this reference velocity occurs on a separately calculated refraction velocity tomogram. Results for predicting current water‐table depth for the 60 surveys gave water‐table depth predictions between 0.38 m above and 0.13 m below the measured water table using a 99% confidence interval. Conventional two‐layer solution predictions resulted in only 28% of predictions lying within 1 m of the measured water table. Using a modification to this approach, we are also able to accurately determine the maximum historical recorded depth to water table using information on soil lithology/texture, records for the greatest recorded depth to water table, and refraction velocity tomograms at known locations. This method can then be applied to locations with similar but known lithology but without monitoring bores.
Nostalgie cherche preneur
Authors: Moiroux Sophie , Vienne Emmanuel de 
Published: September 2015

La nostalgie est désormais une valeur mondialisée, ce qui ne signifie ni qu’elle est partout la même, ni que ceux qui en souffrent le plus en tirent profit en conséquence. Cet article offre à cette proposition générale une illustration, par l’examen des peintures d’Amatiwana Trumai, Indien d’Amazonie brésilienne, et de leur échec à s’insérer sur le marché de l’art. La carrière d’Amati, débutée dans les années 1960, s’ancre dans une existence marquée par la maladie, l’exil, le constat des transformations brutales induites par la colonisation. Figurant pour la plupart la vie qu’il estime avoir perdue (la mythologie, les rituels, la faune et la flore du Haut-Xingu), ses toiles produisent la nostalgie autant qu’elles l’expriment. Mais de quelle nostalgie s’agit-il et à qui s’adresse-t-elle ? Ne suscite-t-elle pas des malentendus sur les notions d’authenticité et d’original ?
Vivre dans le « combattantisme »
Authors: Claverie Élisabeth 
Published: September 2015

L’article décrit les conditions d’entrée dans le « combattantisme » de Germain Katanga, chef d’un groupe armé en Ituri, dans l’est de la République démocratique du Congo, dans les années 1998-2003. Katanga a été accusé de crimes de guerre et de crimes contre l’humanité dans le deuxième procès mis en oeuvre par la Cour pénale internationale (CPI), à La Haye. Cet article a été élaboré à partir d’un travail de terrain à l’intérieur d’une chambre de jugement de la CPI, reposant notamment sur une assistance aux audiences. Avant la montée en puissance de Katanga, l’article détaille les premières séquences de sa trajectoire : de son entrée dans le groupe d’autodéfense de sa communauté jusqu’à ses premières sorties offensives et son obtention du titre de « combattant ». L’article est centré sur le répertoire « maï-maï » de ce groupe et sur le rôle qu’y jouent deux des grands féticheurs-prophètes de la région, Bernard Kakado et Kasaki.
Inhibitory Receptor Expression on CD8+ T Cells Is Linked to Functional Responses against Trypanosoma cruzi Antigens in Chronic Chagasic Patients
Authors: Lasso Paola , Mateus Jose , Pavía Paula , Rosas Fernando , Roa Nubia , Thomas M. Carmen , López Manuel C. , González John M. , Puerta Concepción J. , Cuéllar Adriana 
Published: September 2015

Abstract
In mammals, chronic diseases resulting from infectious agents have been associated with functional T cell response deficiency, a high frequency of terminally differentiated T cells, the presence of monofunctional Ag-specific T cells, and increased expression of inhibitory receptors. Similar to other chronic diseases, the progressive loss of certain functional activities during Trypanosoma cruzi infection might result in the inability to control replication of this parasite. To examine this hypothesis, we evaluated the differentiation and cell effector function of CD8+ T cells and characterized the expression of inhibitory receptors and the presence of the parasite in the bloodstream of chagasic patients. The results showed that patients at an advanced severe disease stage had a higher frequency of terminally differentiated CD8+ T cells than patients at an early stage of the disease. A monofunctional CD8+ T cell response was observed in patients at an advanced stage, whereas the coexpression of markers that perform three and four functions in response to parasite Ags was observed in patients at a less severe disease stage. The frequency of CD8+ T cells producing granzyme B and perforin and those expressing inhibitory receptors was higher in symptomatic patients than in asymptomatic patients. Taken together, these findings suggest that during the course of Chagas disease, CD8+ T cells undergo a gradual loss of function characterized by impaired cytokine production, the presence of advanced differentiation, and increased inhibitory receptor coexpression.