bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emotion dysregulation in adolescents: the associations with clinical symptoms, risky-behaviors, and environmental factors
Authors: Pedrini L. , Meloni S. 
Published: August 2024

IntroductionEmotion dysregulation (ED) is transdiagnostic domain that plays a pivotal role in the emergence and persistence of numerous mental disorders. Examining the extent of ED within non-clinical populations may shed light on whether ED is indeed linked to symptoms as observed in clinical settings. This investigation constitutes a crucial milestone toward the development of preventive strategies.ObjectivesTo investigate the correlations between ED, psychopathological symptoms, risky behaviors, and environmental factors in adolescent students.MethodsA total of N=610 students (16 years; 72% females) completed self-report standardized questionnaires measuring depression, anxiety, impulsivity, childhood trauma, relations with classmates, and family functioning. Lifetime risky-behaviours were recorded using an ad-hoc checklist, and ED through Difficulties in Emotion Regulation Scale (DERS). The sample was then divided into subgroups based on percentiles of DERS Total scores: N=210 low ED, N=187 moderate, N=214 high.ResultsParticipants exhibiting high ED displayed higher level of depression, anxiety and impulsivity (Table 1). There was an observable trend linking higher levels of ED with a greater proportion of youths reporting risky behaviors (Table 2). The high ED group reported an increased frequency of childhood traumatic experiences, less favorable relationships with family members and classmates (Table 3).
Table 1.Clinical symptoms by level of ED in students (N=610)
low
moderate
high
Sig.
Patient Health Questionnaire
(depression)5.33(±3.51)8.94(±4.05)14.57(±5.53)<.001Screen For Child Anxiety Related Emotional Disorders (anxiety)59.27(±9.61)68.61(±10.88)79.39(±11.61)<.001Barratt Impulsiveness Scale-Brief
(impulsivity)15.14(±3.52)16.70(±3.81)18.01(±4.17)<.001Table 2.Risky behaviors by level of ED in students (N=610)
low
moderate
high
Sig.Binge drinkingN=73 (29.6%)N=78 (31.6%)N=96 (38.9%).097Self-harm ideationN=35 (13.4%)N=73 (28%)N=153 (58.6%)<.001Self-harm
N=30 (15%)N=49 (24.5%)N=121 (60.5%)<.001Binge eatingN=60 (22.9%)N=78 (29.8%)N=124 (47.3%)<.001Table 3.Environmental factors by level of ED in students (N=610)
low
moderate
high
Sig.Childhood Trauma Questionnaire (trauma)30.99(±6.89)35.39(±9.1)39.54(±10.94)<.001Child And Adolescent Social Support Scale (classmate)51.19(±11.7)46.55(±10.96)44.91(±12.4)<.001Family Assessment Device (family functioning)117.58(±14)108.8(±17.48)103.38(±20.11)<.001ConclusionsFindings provide robust support for the association between ED and compromised personal functioning, even within a non-clinical sample. The trend observed in the relationship between ED, clinical symptoms and risky behaviors is consistent across all variables. Overall, these results contribute to the growing body of evidence advocating for preventive interventions aimed at addressing ED in adolescents.Disclosure of InterestNone Declared
Gender Diversity-Related Mental Health Care: Evidence, Trends, Obstacles
Authors: Başar K. 
Published: August 2024

Abstract
Gender identity may be experienced within a broad spectrum beyond the binary understanding of sex concerning genital characteristics. In people with gender identities not congruent with the gender culturally associated with the sex assigned at birth, distress related to biopsychosocial correlates of this condition may arise. In current diagnostic systems, this is considered within the framework of “Gender Incongruence” (ICD-11) and “Gender Dysphoria” (DSM 5). Although this diversity is known to be present throughout the ages, the terms related to gender identity were introduced to medical literature a hundred years ago. They were popularized with the advances in medical procedures that assist individuals in acquiring physical features aligning with their gender identity and expression. There has been an increase in research interest with increasing numbers in medical centers working on gender-affirmative medical procedures. Starting from the 1970s, international organizations prepared guidelines on the standards of care for trans and gender diverse (TGD) individuals. Despite all the progress in the gender-affirming medical care provided to TGD individuals and the changes in the legal recognition of gender, health inequalities persist globally. The discrepancy in mental and physical health conditions has long been shown to be associated with “minority stress.” The minority stress perspective suggests that distal and proximal chronic stressors arising from society are associated with adverse health outcomes for TGD individuals. Resilience against these stressors is more robust with better coping styles and social support. Lately, structural stigma and discrimination have been shown to be an important source of inequality. Therefore, much more progress is still required with respect to societal inequalities, human rights, and structural transphobia for the improvements in medical care to impact the global health condition of TGD people. However, lately, there have been attempts to restrict TGD individuals’ access to medical care and their legal rights, even if they were not close to the level they ought to be. This backlash mostly sits on the discussion on the management of TGD adolescents and children. Models of care for these age groups have been developed for decades, and despite evidence of the protective and beneficial effects on health and development, in many countries, there are attempts to block their access to medical care. Growing debate on TGD care turned into a political combat, where scientific evidence and human rights perspectives are often ignored. These tendencies present a strong challenge for public health and the professional identity and practice of healthcare professionals.Disclosure of InterestNone Declared
Projective technique “Bird’s Nest Drawing” in child clinical psychology
Authors: Zvereva M. , Zvereva N. , Sergienko A. , Strogova S. , Klak D. , Antonova E. , Balakireva E. 
Published: August 2024

IntroductionThe “Bird’s Nest Drawing” technique is one of expressive drawing projective techniques. In Russia it has been used since the 2020s. We suggest the pilot version of using this projective technique in child clinical psychology. There were investigated the cognitive and emotional components of performance by children with different types of ontogenesis.Purpose: pilot application of the technique of “Bird’s Nest Drawing” (BND) in the psychological diagnosis of children with different types of ontogenesis.Objectives69 children and adolescents 6-17 years old (28 male), examined at the Mental Health Research Center. 1. hospital patients (11-16 years old, 18 persons) diagnoses F20.8, F21.4, 2) outpatient clients with psychological diagnostics (7-16 years old, 45 persons), most of them have psychiatric diagnoses and some of them came for a consultation independently of doctors (there were family and behavior problems). 3) children conceived with the help of assisted reproductive technologies (IVF) - participants in a program for studying cognitive and emotional-personal development (5-13 years old, 8 people). Control group of normal children (14 persons).MethodsBird’s Nest Drawing (D.Kaiser, 2003, Kuftyak, 2021) - clinical expert assessment of the drawing parameters (size, location, quality, compliance with instructions) and the emotional component (color, self-assessment of the drawing).Results
Table 1.Frequency of different indicators of BND in compared groups of children.

Groups

N
Central place
High Quality of drawing
Nest out of tree
birds /eggs
Different colors
Safety of nest
High Assessment by participants
High positive emotional expression Assessment by expertsHospital patients18 (4 m)12410410**413**5**Outpatient clients45 (22 m)38131917321025**17Children IVF8 (2 m_72436**163Normal children14(6 m)1437412**413**11**** - significance of the differences (p≤0,05 by φ criterion).Based on the data obtained, it can be noted that the most different between groups turned out to be an indicator for using different colors, subject’s assessment his picture and emotional expression assessment of picture by experts. Other parameters are similar: please of drawing,DiscussionWe have obtained our own resalts about BND method in children with different type of ontogenesis. These data are similar to D.Kaiser and E.Kuftyak in opportunity of good diagnostic practice of BND method in children and adolescents with different type of ontogenesis in scientificConclusionsBND method is a good test for child clinical psychology as a projective one. Restrictions of this investigation - small groups, simple parameters for assessment. We plan to continue this work with more clinical (diagnosis, syndrome et cetera) and sex and age characteristics.Disclosure of InterestNone Declared
The biological modeling of autism spectrum disorders
Authors: Sidenkova A. 
Published: August 2024

IntroductionAutism Spectrum Disorders (ASD) are heterogeneous pathological conditions characterized by difficulties in establishing social contacts and the manifestation of repetitive behavior. An atypical trajectory of brain maturation, impaired neurogenesis, synaptogenesis, and an imbalance in the excitatory and inhibitory systems of the CNS form the morphofunctional basis of the ASDObjectivesscientific publicationsMethodsscientific analysisResultsThese pathological changes appear at different stages of brain maturation They are the result of multifactorial environmental influences. To understand the functioning of this complexly organized system in time and space, a three-dimensional model is needed. The closest in vitro model of the human brain from early embryonic stages to aging is brain organoids. Human brain organoids are self-organizing three-dimensional cell aggregates derived from pluripotent stem cells. Organoids summarize neurogenesis, gliogenesis, synaptogenesis, cell migration and cell differentiation, gyrification of the cerebral cortex, reflect the connections of brain regions. The use of a 3D brain model makes it possible to simulate diseases, reactions to drugs in cells obtained from patients. The use of telencephalon organoids in the ASD model revealed that neuronal migration deficiency, acceleration and disruption of cell cycle synchronization, aberrant cell proliferation, abundant synaptogenesis, temporary deviations in the development of the cortex, increased branching of neurons, unbalanced inhibitory differentiation of neurons, high activity of ion channels are the result of impaired activity FOXG1. FOXG1 is responsible for the overproduction of GABAergic neurons. The shift towards GABAergic neurons induced by FOXG1 is positively correlated with the severity of ASD symptoms and is seen as a precursor to the future of ASDConclusionsThus, ASD as a socially significant disease with a heterogeneous type of inheritance, multi-link pathogenesis, realized in different periods of ontogenesis and involving different brain loci, requires special attention of researchers for the personification of diagnosis and therapy. The hiPSCs can provide insight into the cellular mechanisms underlying ASD as a neuropsychiatric disorder, providing access to the development of platforms for in vitro drug screening and patient-tailored therapy.Disclosure of InterestNone Declared
Watersports Inclusion Games: The Benefits for Participants and the Impact of COVID-19 on Access
Authors: Killalea M. , Warraitch A. , Murphy J. , Barrett E. 
Published: August 2024

IntroductionThe Watersports Inclusion Games is a free annual weekend event, where young people with a range of physical and intellectual disabilities and their families/siblings participate in various inclusive watersports activities.ObjectivesThis study aims to assess the psychological benefits of watersports for young people with various physical and intellectual disabilities and investigate the extent of the impact of the COVID-19 pandemic on their access to watersports.MethodsFollowing a literature review, a survey containing both quantitative and qualitative aspects was constructed using SurveyMonkey and circulated to the parents/guardians of participants three times following the event. The survey was completed anonymously on an opt-in basis and 28 responses that met our criteria for analysis were collected. Qualitative data from free-text responses were grouped under themes and quantitative data was analysed using SPSS.ResultsDespite 64% (n=18) of respondents indicating that their disability increased their vulnerability to COVID-19 in some capacity, the effect of the pandemic on accessibility was not statistically significant. This could be due to the small response number, or the everyday limitations participants faced prior to the pandemic. 92% (n=25) of participants indicated that there was great inclusion in the watersports activities and that they were “very beneficial” regarding the possibility of the whole family’s participation [p=0.005]. The survey also found a statistically significant association between the event’s activities being considered both “accessible” and “very beneficial” in terms of boosting self-confidence, with 57.1% of responses indicating agreement to this. (p=0.016)ConclusionsFull-family participation and accessibility of activities were key facilitators to the enjoyment and benefit of participants. Programmes should be established that allow able-bodied siblings and young people with disabilities to participate in the same activities.Disclosure of InterestNone Declared
Impulsivity: A Dimensional Perspective in PD and ED. Comparison of Results in a Case-Control Study.
Authors: Pérez-Lombardo M. , Alberdi-Páramo Í. , Ayad-Ahmed W. , Carrasco-Perera J. L. , Díaz-Marsá M. 
Published: August 2024

IntroductionPersonality Disorders (PD) - specifically Borderline Personality Disorder (BPD), and certain Eating Disorders (ED) share common clinical features. One of these features is impulsivity, studied individually in each diagnostic group, and scarcely used to encompass specific profiles of these patients.Understanding the common clinical variables of this patient population would facilitate therapeutic efforts and enable greater precision regarding the prognosis of these patients.ObjectivesThis study aims to study impulsivity in a group collectively formed by BPD and ED, compared to a control group, in contrast to the individualized study approach typically conducted in the literature.MethodsA cross-sectional descriptive study is conducted to assess impulsivity as a common diagnostic variable in a group of PD and ED in comparison with a healthy control group. The sample was collected between 2016 and 2019 at the Hospital Clínico San Carlos, totaling 108 subjects.ResultsA statistically significant difference is observed (p<0.005 in all scales) in total impulsivity, cognitive impulsivity, motor impulsivity, and unplanned impulsivity in the cases group comprising patients diagnosed with PD and ED, compared to the control group from the general population.ConclusionsImpulsivity is closely related to the concept of borderline personality disorder. This analysis also includes eating disorders, with the difference from the control group still statistically significant.The presence of common clinical variables in these groups (PD and ED) may have clinical and therapeutic implications that differ from those pursued thus far. This allows moving away from the categorical model and understanding these disorders from a more enriching and advanced dimensional perspective.”Disclosure of InterestNone Declared
Exploring the connections between psychiatric disorders and climate change
Authors: Marinić I. , Mužinić Marinić L. 
Published: August 2024

IntroductionConsidering the increased occurrence of climate changes in the world and their consequences on human health and quality of life, there is an increase in psychiatric disorders, including anxiety disorders, mood disorders, and stress related disorders caused by climate changes.ObjectivesTo explore the connections between psychiatric disorders and certain types of climate change.MethodsData from research related to climate change and its impact on mental health are presented.ResultsResearch indicates an increase in psychological disorders related to climate change from several diagnostic categories, consequently to the acute and long-term effects of climate changes, depending on the type of climate event, individual sensitivity, socioeconomic conditions, community support and assistance, and response to therapeutic interventions.ConclusionsIn addition to raising awareness of the impact of climate change on psychological health, it is important to develop strategies for providing psychological and psychiatric assistance, both immediately after a climate event and during long-term exposure to adverse climate conditions, especially for vulnerable groups.Disclosure of InterestNone Declared
Impact of addictive comorbidity on bipolar disorder type I
Authors: Adouni A. , Zgueb Y. , Ben Othman F. , Bouguerra I. , Jomli R. 
Published: August 2024

IntroductionAmong all mental pathologies, bipolar disorder (BD) is the one in which addictive comorbidity is most frequent.Recent studies suggest that this comorbidity has harmful consequences, threatening patients’ quality of life.ObjectivesDescribe addictive comorbidity and determine its prevalence in a population of patients with BD I.Study the impact of addictive comorbidity on the evolution of BD I.MethodsA cross-sectional, comparative study was conducted over a six-month period in the after-care unit of psychiatric wards at Razi Hospital, including patients treated for BD I according to DSM 5 criteria and stable on treatment.The study included two phases: first, sociodemographic, clinical and therapeutic characteristics were collected using a pre-established form. The CAGE, DUDIT and MARS scales, validated in Arabic, were then administered.ResultsWe included 100 patients (60 men and 40 women) with a mean age of 43.55 years.Substance use disorder (SUD) was reported in 31% of our population; 22 alcohol users with a mean CAGE score of 1.23 (0-3), while psychoactive substance use was reported in 19 patients with a mean DUDIT score of 13.37 (0-28).Forensic history was higher in the group of patients with comorbid SUD (p<0.001). Poor compliance with treatment and irregular follow-up were also significantly more associated with addictive behavior, respectively p=0.008 and p=0.048.We found no association between SUD and suicidal behavior or evolutionary symptoms of the disorder.Conclusions
SUD are generally factors in the poor prognosis of BD. It is important to identify the determinants of this comorbidity, so that these risk factors can be appropriately targeted through appropriate therapeutic interventions and thus limit these negative consequences.Disclosure of InterestNone Declared
Concurrent Gender Dysphoria/Incongruence and Autism Spectrum Disorder, a literature review
Authors: Clementi N. 
Published: August 2024

IntroductionSeveral studies have found that ASD (Autism Spectrum Disorder) and GD (Gender Dysphoria by DSM-V)/GI (Gender Incongruence by ICD-11) tend to co-occur, and in recent years the interest and publications on this comorbidity has increased rapidly.ObjectivesTo review the prevalence of ASD in individual with a diagnosis of GD/GI.To better tailor and improve care offered in the National Health Service (NHS) Gender Identity Clinics (GICs) throughout the UK.MethodsSystematic literature review was conducted via Pub Med, MEDLINE and PsycINFO by the author, for all English-language articles published between 2018 and 2023, containing keywords as ASD, GD (Gender Dysphoria), GI (Gender Incongruence), transgender, autistic traits, autism, gender diversity, gender variance.ResultsRate of people with ASD appear to be higher in people accessing Gender Identity Clinics (GICs) than in the general population. Results from this literature review show increased prevalence of GD and GI in ASD population.ConclusionsThis comorbidity has highlighted the importance of better tailor transgender healthcare services for people with neurodevelopmental conditions and neurodiversity, to avoid delay in ASD individuals accessing care and gender affirming medical treatments. Services should strive to provide an effective and equitable service. It is also important to better identify potential barriers for ASD people in accessing gender care. Literature also shows the people with ASD have more difficulties in communicating and describing their gender narrative and to express their wishes for gender treatments. Symptoms including problems in communications and social skills, obsession and rigidity can also impact their assessment of GD/GI in gender identity services. Some studies showed that for individuals who have concurrent ASD and GD/GI, assessment in GICs may be extended to better review their wishes for gender identity and for gender affirming treatment. Further research is needed to better investigate and understand factors explaining the relationship between ASD and gender diversity. There is still limited research in the real life experiences of gender diverse and autistic people. There is also a need to improve Gender reassignment protocol nationally to better care for individual with ASD and GD/GI throughout GICs in the UK.Disclosure of InterestNone Declared
Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex
Authors: Paramore Sarah V. , Goodwin Katharine , Fowler Eric W. , Devenport Danelle , Nelson Celeste M. 
Published: August 2024

ABSTRACT
Adult mammalian lungs exhibit a fractal pattern, as each successive generation of airways is a fraction of the size of the parental branch. Achieving this structure likely requires precise control of airway length and diameter, as the embryonic airways initially lack the fractal scaling observed in the adult. In monolayers and tubes, directional growth can be regulated by the planar cell polarity (PCP) complex. Here, we characterized the roles of PCP complex components in airway initiation, elongation and widening during branching morphogenesis of the lung. Using tissue-specific knockout mice, we surprisingly found that branching morphogenesis proceeds independently of PCP complex function in the lung epithelium. Instead, we found a previously unreported Celsr1-independent role for the PCP complex components Vangl1 and Vangl2 in the pulmonary mesenchyme, where they are required for branch initiation, elongation and widening. Our data thus reveal an explicit function for Vangl1 and Vangl2 that is independent of the core PCP complex, suggesting a functional diversification of PCP complex components in vertebrate development. These data also reveal an essential role for the embryonic mesenchyme in generating the fractal structure of airways in the mature lung.