bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinicopathologic features of hyperplastic/serrated polyposis syndrome in Japan
Authors: Miwata Tomohiro , Hiyama Toru , Oka Shiro , Tanaka Shinji , Shimamoto Fumio , Arihiro Koji , Chayama Kazuaki 
Published: June 2013

AbstractBackground and AimHyperplastic/serrated polyposis syndrome (HPS) is a condition characterized by multiple hyperplastic/serrated colorectal polyps. The risk of colorectal cancer (CRC) is increased in HPS. The clinicopathologic characteristics of HPS in Japanese patients are unknown.The aim of this study is to clarify the clinicopathologic features of HPS in Japanese patients.MethodsWe retrieved records of patients diagnosed with HPS between April 2008 and March 2011 from the endoscopy database of Hiroshima University Hospital. In addition, we mailed a questionnaire to the hospital's 13 affiliated hospitals in July 2012. Data collected from the database and questionnaires included patient age, sex, number of hyperplastic/serrated polyps and tubular adenomas, size of the largest polyp, polyp location, resection for polyps, coexistence of HPS with CRC, and the diagnostic criterion met.ResultsOf the 73 608 patients who underwent colonoscopy, 10 (0.014%) met the criteria for HPS. The mean age of these patients was 58.3 years, and 6 (60%) were men. No subjects had a first‐degree relative with HPS. Four (40%) HPS patients had more than 30 hyperplastic/serrated polyps, and average size of the largest polyp was 19 mm. Three (30%) HPS patients had coexistence of HPS with CRC. In these 3 patients, polyps were observed throughout the colorectum.ConclusionsAlthough HPS was a rare condition in the overall study population, patients with the disease may have high risk of CRC. HPS should be diagnosed correctly and followed up carefully.
Elevated serum dopamine increases while coffee consumption decreases the occurrence of reddish streaks in the intact stomach
Authors: Chen Tseng‐Shing , Chang Full‐Young 
Published: June 2013

AbstractBackground and AimReddish streaks in an intact stomach are an endoscopic feature of duodenogastric reflux. This study aimed to identify which factors are associated with gastric reddish streaks and thus help prevent mucosal damage from duodenogastric reflux.MethodsDemographic data, personal habits, stressful life events, and psychological distress were compared between subjects with only gastric reddish streaks and those with normal mucosa who underwent upper gastrointestinal endoscopy as part of a self‐paid physical checkup. Stress hormones dopamine and cortisol were also checked by high‐performance liquid chromatography and radioimmunoassay methods respectively.ResultsThere were 95 subjects with gastric reddish streaks and 52 subjects with normal mucosa. No significant differences in age, gender, blood groups, education levels, marital status, religion, aspirin or nonsteroidal anti‐inflammatory drug (NSAID) use, smoking habit, alcohol consumption, and intake of tea was found between the two groups, but intake of coffee was borderline more common in subjects with normal mucosa (38.5% vs 22.1%, P = 0.055). Subjects with gastric reddish streaks had lower Helicobacter pylori infection rate (37.8% vs 19.3%, P < 0.05). There were no significant differences in psychological distress and stressful life events between the two groups. Multivariate analysis shows that serum dopamine concentrations (odds ratio = 11.31, 95% confidence interval = 2.11–60.48, P = 0.005) and being without the consumption of coffee (odds ratio = 2.97, 95% confidence interval = 1.27–6.94, P = 0.012) were associated with gastric reddish streaks.ConclusionsElevated serum dopamine and less coffee consumption are associated with gastric reddish streaks. These findings implicate that increased dopamine level plays a role for abnormal duodenogastric reflux.
The effect of acute auditory stress on gastric motor responses to a meal in healthy volunteers
Authors: Lee Hong Sub , An Young‐Sil , Kang Joonkoo , Yoo Jun Hwan , Lee Kwang Jae 
Published: June 2013

AbstractBackground and AimStress is believed to play a role in the pathogenesis of functional gastrointestinal disorders. The aim of the present study was to investigate the effect of acute auditory stress on gastric motor responses to a meal in healthy subjects.MethodsA total of eight healthy volunteers (seven men and one woman; median age, 33.4 years [30–35 years]) who had no recurrent gastrointestinal symptoms participated in the prospective, randomized, crossover study. Gastric half‐emptying time and meal‐induced proximal gastric accommodation were measured using gastric scintigraphy under the auditory stress and control conditions in a randomized crossover design.ResultsThe gastric half‐emptying time under the stress condition was significantly longer than that under the control condition (130.8 ± 16.6 vs 105.0 ± 13.1 min; P = 0.005 by paired t‐test). Under the stress and control conditions, the proximal gastric volume significantly increased after a meal (P < 0.001 by repeated measures analysis of variance). The degree of the postprandial increase in proximal gastric volume did not significantly differ between both conditions (P = 0.598 by tests of between‐subjects effects using repeated measures analysis of variance). The severity scores of postprandial epigastric discomfort and fullness were significantly higher under the stress condition than under the control condition (P = 0.001 and P = 0.039, respectively, by paired t‐test).ConclusionsAcute auditory stress delays gastric emptying and increases the severity of postprandial symptoms in the healthy subjects, suggesting the relevance of psychological stress to the pathophysiological mechanism of functional dyspepsia.
Binding of the repressor complex REST‐mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models
Authors: Conforti Paola , Zuccato Chiara , Gaudenzi Germano , Ieraci Alessandro , Camnasio Stefano , Buckley Noel J. , Mutti Cesare , Cotelli Franco , Contini Alessandro , Cattaneo Elena 
Published: June 2013

AbstractTranscriptional dysregulation is a hallmark of Huntington's disease (HD) and one cause of this dysregulation is enhanced activity of the REST‐mSIN3a‐mSIN3b‐CoREST‐HDAC repressor complex, which silences transcription through REST binding to the RE1/NRSE silencer. Normally, huntingtin (HTT) prevents this binding, allowing expressing of REST target genes. Here, we aimed to identify HTT mimetics that disrupt REST complex formation in HD. From a structure‐based virtual screening of 7 million molecules, we selected 94 compounds predicted to interfere with REST complex formation by targeting the PAH1 domain of mSIN3b. Primary screening using DiaNRSELuc8 cells revealed two classes of compounds causing a greater than two‐fold increase in luciferase. In particular, quinolone‐like compound 91 (C91) at a non‐toxic nanomolar concentration reduced mSIN3b nuclear entry and occupancy at the RE1/NRSE within the Bdnf locus, and restored brain‐derived neurotrophic factor (BDNF) protein levels in HD cells. The mRNA levels of other RE1/NRSE‐regulated genes were similarly increased while non‐REST‐regulated genes were unaffected. C91 stimulated REST‐regulated gene expression in HTT‐knockdown Zebrafish and increased BDNF mRNA in the presence of mutant HTT. Thus, a combination of virtual screening and biological approaches can lead to compounds reducing REST complex formation, which may be useful in HD and in other pathological conditions.
image
Dysregulation of REST and its target genes have been implicated in Huntington's disease. We have coupled structured‐based virtual screening approaches to biological assays and selected molecules that interfere with the repressor complex REST‐mSIN3b. In particular, at the non‐toxic dose, compound C91 is able to increase neuronal gene transcription and to reverse low Bdnf mRNA levels in HD models.
Burkitt lymphoma of the ovary: A case report and literature review
Authors: Miyazaki Noriko , Kobayashi Yoichi , Nishigaya Yoshiko , Momomura Mai , Matsumoto Hironori , Iwashita Mitsutoshi 
Published: June 2013

AbstractWe report an extremely rare case of primary ovarian Burkitt lymphoma. A 15‐year‐old girl was referred to our department because of persistent constipation and abdominal distension. Abdominal computed tomography and magnetic resonance imaging revealed a 10‐cm‐diameter solid tumor located on the right side of the uterus. Serum lactate dehydrogenase and carbohydrate antigen‐125 levels were elevated at 3250 IU/L and 235.7 U/mL, respectively. Initially, ovarian dysgerminoma was suspected, but poor performance and progressive disease were suggestive of malignant lymphoma. However, bone marrow aspiration and ascitic fluid cytology findings were not indicative of lymphoma. Laparotomy was performed to confirm pathology. On laparotomy, the right ovary was firm and enlarged, but the uterus and left ovary were normal. Diffuse thickness of retroperitoneal space was observed. Right salpingo‐oophorectomy was performed, and the tumor was diagnosed as Burkitt lymphoma. Although intensive chemotherapy was administered, the patient died 171 days after the initial operation.
Frequency of MEFV mutation and genotype–phenotype correlation in cases with dysmenorrhea
Authors: Ocak Zeynep , Ocak Tarık , Duran Arif , Ozlü Tülay , Kocaman Ertugrul Mevlut 
Published: June 2013

AbstractAimWe aimed to investigate the relation between mutations and polymorphisms playing roles in the onset of clinical findings of Familial Mediterranean Fever (FMF) and clinical phenotypic reflections manifesting with painful episodes, such as dysmenorrhea.Material and MethodsA total of 1000 female patients who had not responded well to non‐steroidal anti‐inflammatory drugs in the menstrual period, and who had presented to the emergency room with the complaint of recurrent pain episodes were included in the study. All the patients were Turkish women living in Istanbul. In this study, the mutations most frequently seen in the Mediterranean Fever Gene (MEFV), namely M694V, E148Q, M680I(G/C), V726A, P369S, R761H, A744S, M694I, K695R, F479L, M680I(G/A), and I692del were examined using the DNA sequence analysis following DNA isolation.ResultsThe number of individuals who had a mutation in at least one allele for FMF was 511 out of 1000 patients. Of these 511 patients, homozygous mutations were found in 21% (n = 109), compound heterozygous mutations were found in 27% (n = 136), and heterozygous mutations were found in 52% (n = 266). The most frequent homozygous genotype seen in our study population was M694V/M694V. The most common compound heterozygote genotypes were M694V/M680I, M694V/V726A, M694V/E148Q, and M680I/V726A; and 11.7% (n = 60) of the families in whom mutations were found had consanguinity.ConclusionWomen who present to the emergency room with the complaint of dysmenorrhea that is irresponsive to non‐steroidal anti‐inflammatory drugs may have several types of MEFV mutations that are responsible for FMF.
Maternal tumor necrosis factor receptor 2 gene variants associated with pre‐eclampsia in Tunisian women
Authors: Said Lamia , Faleh Raja , Smida Samia , Laajili Hayet , Sakouhi Mohamed , Bel Hadj Jrad Besma 
Published: June 2013

AbstractAimThe tumor necrosis factor receptor 2 (TNFR2) is expressed in placental tissue and it is involved in immune responses, inflammation, angiogenesis and blood pressure regulation; which makes it an attractive pre‐eclampsia (PE) candidate gene. Furthermore, TNFR2 expression is altered in the first trimester in placentas of women who are destined to develop PE. Therefore, we examined the association between maternal and fetal genetic variants of TNFR2 and PE.Material and MethodsWomen with PE (n = 157) and their offspring with PE (n = 60) were compared to a control group of women (n = 97) and their offspring (n = 52) in the same Tunisian hospital‐based population. We genotyped by polymerase chain reaction and restriction fragment length polymorphism the T/G polymorphism at position 676 in exon 6 (rs1061622) of the TNFR2 gene and examined its association with PE.ResultsThe frequencies of TNFR2 (G/G) genotype and G allele were higher in the mothers with PE (n = 154) compared to the control group (15.3% vs 4.1% and 37% vs 26.3%, respectively); furthermore, the difference reached statistical significance (P = 0.002, odds ratio = 4.9; 95% confidence interval: 1.69–17.4 and P = 0.03, odds ratio = 1.69; 95% confidence interval: 1.03–2.8, respectively). In contrast, the fetal genotype and allele frequencies of this polymorphism had no effect on the risk of PE.ConclusionsThe exon 6 polymorphism in TNFR2 (rs1061622) or a gene at proximity is associated specifically with PE at least in the Tunisian population and could increase the risk for PE for mothers carrying the homozygote minor allele. Nevertheless, these results need to be confirmed in other populations.
Sexual and Relationship Intimacy Among Women with Provoked Vestibulodynia and Their Partners: Associations with Sexual Satisfaction, Sexual Function, and Pain Self-Efficacy
Authors: Bois Katy , Bergeron Sophie , Rosen Natalie O. , McDuff Pierre , Grégoire Catherine 
Published: June 2013

ABSTRACT

Introduction
Provoked vestibulodynia (PVD) is the most frequent subtype of vulvodynia. Women report negative consequences of PVD on their sexual and romantic relationships. Researchers have recently highlighted the importance of examining interpersonal factors such as intimacy, and of including both women and their partners in study designs.

Aim
The aim of this study was to investigate sexual and relationship intimacy as defined by the Interpersonal Process Model of Intimacy and their associations with sexual satisfaction, sexual function, pain self-efficacy, and pain intensity among women with PVD and their partners.

Methods
Ninety-one heterosexual women (M age = 27.38, SD = 6.04) diagnosed with PVD and their partners (M age = 29.37, SD = 7.79) completed measures of sexual and relationship intimacy, sexual satisfaction, sexual function, pain self-efficacy, and pain intensity.

Main Outcome Measures
Dependent measures were the (i) Global Measure of Sexual Satisfaction Scale; (ii) Female Sexual Function Index; (iii) Painful Intercourse Self-Efficacy Scale; and (iv) visual analog scale of pain intensity during intercourse.

Results
After controlling for women's age, women's greater sexual intimacy (β = 0.49, P &lt; 0.001) was associated with women's greater sexual satisfaction and higher pain self-efficacy (β = 0.39, P = 0.001), beyond the effects of partners’ sexual intimacy. Also, women's greater sexual intimacy (β = 0.24, P = 0.05) and women's greater relationship intimacy (β = 0.54, P = 0.003) were associated with greater women's sexual function, beyond the effects of partners’ sexual and relationship intimacy.

Conclusions
Women's self-reported sexual and relationship intimacy in the couple relationship may promote higher sexual satisfaction, sexual function, and pain self-efficacy, as well as possibly foster greater sexual well-being among women with PVD. The authors discuss implications for the inclusion of emotional and interpersonal aspects of the couple's dynamic in clinical interventions and future research in PVD.
Accuracy of 30-Day Recall for Components of Sexual Function and the Moderating Effects of Gender and Mood
Authors: Weinfurt Kevin P. , Lin Li , Dombeck Carrie B. , Broderick Joan E. , Snyder Denise C. , Williams Megan S. , Fawzy Maria R. , Flynn Kathryn E. 
Published: June 2013

Abstract

Introduction
Despite the ubiquity of 1-month recall periods for measures of sexual function, there is limited evidence for how well recalled responses correspond to individuals' actual daily experiences.

Aim
To characterize the correspondence between daily sexual experiences and 1-month recall of those experiences.

Methods
Following a baseline assessment of sexual functioning, health, and demographic characteristics, 202 adults from the general population (101 women, 101 men) were recruited to complete daily assessments of their sexual function online for 30 days and a single recall measure of sexual function at day 30.

Main Outcome Measures
At the baseline and 30-day follow-ups, participants answered items asking about sexual satisfaction, sexual activities, interest, interfering factors, orgasm, sexual functioning, and use of therapeutic aids during the previous 30 days. Participants also completed a measure of positive and negative affect at follow-up. The main outcome measures were agreement between the daily and 1-month recall versions of the sexual function items.

Results
Accuracy of recall varied depending on the item and on the gender and mood of the respondent. Recall was better (low bias and higher correlations) for sexual activities, vaginal discomfort, erectile function, and more frequently used therapeutic aids. Recall was poorer for interest, affectionate behaviors (e.g., kissing), and orgasm-related items. Men more than women overestimated frequency of interest and masturbation. Concurrent mood was related to over- or underreporting for six items addressing the frequency of masturbation and vaginal intercourse, erectile function, and orgasm.

Conclusions
A 1-month recall period seems acceptable for many aspects of sexual function in this population, but recall for some items was poor. Researchers should be aware that concurrent mood can have a powerful biasing effect on reports of sexual function.
Effects of Genes and Environment on the Fetoplacental Arterial Microcirculation in Mice Revealed by Micro‐Computed Tomography Imaging
Authors: Rennie Monique Y. , Sled John G. , Adamson S. Lee 
Published: June 2013

AbstractThe fetoplacental arterial tree is critical for efficient distribution of arterial blood to capillaries throughout the placental exchange region; yet, little is known about the factors and mechanisms that control its development. Advances in micro‐CT imaging and analysis, and available mutant mouse strains, are facilitating rapid progress. Indeed, micro‐CT studies show that genetic differences between the CD1 and C57Bl/6 mouse strains, and between Gcm1 heterozygotes and wild‐type littermates alter the developmental trajectory of the fetoplacental arterial tree as do environmental factors including maternal exposure to toxins in cigarette smoke and malarial infection. Relative to other vascular beds, the fetoplacental arterial tree is particularly tractable because veins can more easily be excluded when infusing the contrast agent and because of the placenta's small size, which means that the whole organ can be imaged (maintaining connectivity) and that the tree is simpler (fewer branching generations). Despite these differences, measured parameters were found to be similar to arterial trees in other adult rodent organs. Thus, micro‐CT analysis provides a means for advancing of our understanding of the mechanisms controlling development of the fetoplacental arterial tree. Results will likely have relevance to other arterial vasculatures as well.
Do Foreign-owned Subsidiaries in China Follow a Distinctive Pattern of Technological Knowledge Sourcing?
Authors: Cantwell John A. , Zhang Feng 
Published: June 2013

AbstractThis study investigates the China-located subsidiaries of foreign-owned multinational corporations (MNCs) for patterns of intra-firm and interorganizational technological knowledge accumulation. We analyze US patents attributed to those subsidiaries between 1996 and 2005 and argue that MNCs have recently tended toward open network structures, enabling subsidiaries in emerging markets to develop technological capabilities by searching for diversified inter-organizational knowledge sources beyond geographically local contexts to compensate for local limitations and deficiencies. Findings show that subsidiaries in China have gradually developed their technological capabilities through non-localized searches beyond their organizational, technological, and geographical boundaries. The study contributes to the literature on MNC organizational restructuring, subsidiary evolution, and subsidiary-level non-localized knowledge searches. The findings also have important implications for knowledge spillovers, MNC knowledge management, and government policies.
Food allergy knowledge of parents – is ignorance bliss?
Authors: Goossens Nicole J. , Flokstra‐de Blok Bertine M. J. , van der Meulen Gerbrich N. , Botjes Erna , Burgerhof Hans G. M. , Gupta Ruchi S. , Springston Elizabeth E. , Smith Bridget , Duiverman Eric J. , Dubois Anthony E. J. 
Published: June 2013

AbstractBackgroundFood allergic children are at least partially dependent on their parents to care for their food allergy. In addition, parents are often responsible for the education of others regarding food allergy, including the family, school, neighbors, and friends. The aim of this study was to investigate food allergy knowledge, attitudes, and beliefs of parents with food allergic children in the Netherlands. In addition, a cross‐cultural comparison was made between parents from the USA and parents from the Netherlands.MethodsThe original Chicago Food Allergy Research Survey for Parents of Children with Food Allergy (CFARS‐PRNT) was translated into Dutch. Parents of children with at least one doctor‐diagnosed food allergy were included. Knowledge scores and attitude/beliefs scores were determined and compared with the data from 2945 parents from the USA. Predictors of overall knowledge scores were investigated.ResultsDutch parents of children completed the translated CFARS‐PRNT (n = 299). The mean overall knowledge score in the Netherlands was 9.9 after adjusting for guessing, compared with 12.7 in the USA (p < 0.001). Attitudes and beliefs regarding food allergy among parents from the Netherlands were generally more optimistic. The overall knowledge scores could be predicted by country of origin, educational degree, being member of a patient organization, visiting an allergist, and a history of anaphylaxis.ConclusionsFood allergy knowledge among parents of food allergic children from the Netherlands is suboptimal when compared with their counterparts from the USA, although these parents tend to be more optimistic toward food allergy than parents from the USA.
Analysis of carotenogenic gene expression in petals and leaves of carnation (Dianthus caryophyllus L.)
Authors: Ohmiya Akemi , Tanase Koji , Hirashima Masumi , Yamamizo Chihiro , Yagi Masafumi 
Published: June 2013

AbstractCarnation (Dianthus caryophyllus L.) belongs to the family Caryophyllaceae in the order Caryophyllales. Plants in this order do not accumulate carotenoids in petals. To understand how carotenoid accumulation is controlled in carnation petals, we analysed the expression of genes related to carotenoid accumulation. Petals at an early stage of development accumulated small amounts of carotenoids. As petals matured, their carotenoid content decreased to extremely low levels. In contrast, carnation leaves contained substantial amounts of carotenoids that are essential for photosynthesis. Most of the carotenogenic genes were expressed in petals at levels similar to those in leaves, and the expression levels of these genes increased during petal development. Genes encoding phytoene synthase and lycopene ε‐cyclase were exceptions. Their expression levels in petals were very low compared with those in leaves. Expression of the gene encoding carotenoid cleavage dioxygenase 4 was detected in neither leaves nor petals. These data suggest that the low levels of carotenoids in carnation petals are caused not by enzymatic degradation but rather by low rates of carotenoid biosynthesis.