bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guidelines for treating mental illness: love them, hate them. Can the SIEP-DIRECT's Project serve in the search for a happy medium?
Authors: Ruggeri Mirella 
Published: October 2015

SUMMARYThis paper discusses some key aspects of the debate on the difficulties of incorporating scientific evidence into the daily work of clinicians in mental health services (MHS). It highlights the topics of: the utility of guidelines in this field, the ethical principles that should guide their utilisation, their limitations, obstacles impeding the diffusion of guidelines in psychiatry, and strategies that can be useful for overcoming the barriers to guideline implementation. The SIEP-DIRECT's ((DIscrepancy between Routine practice and Evidence in psychiatric Community Treatments on Schizophrenia) Project's potential role in fostering this advancement is discussed in detail. This Project developed a set of 103 indicators that operationalised the NICE clinical guidelines for schizophrenia recommendations and tested them in 19 MHS in Italy. A multi-step design was used to assess recommendation and indicator acceptability in the Italian context; provide an assessment of any current discrepancies between routine practice and guideline recommendations in the treatment of schizophrenia; and understand the reasons for any discrepancies that might emerge. This process, moreover, was instrumental in keeping the debate arising during conduction of this Project far from the excesses of hostility - and excesses of “bright-eyed enthusiasm” - that frequently influence discussion on topic. This Project therefore showed potential to serve in the search for a happy medium, that can facilitate the pursuit of a fundamental advancement in guideline implementation in mental health services.Declaration of Interest: None.
Dual Defection Incentives in One System: Party Switching under Taiwan's Single non-transferable Vote
Authors: CHANG ALEX , TANG YEN-CHEN 
Published: October 2015

AbstractPolitical scientists generally consider that the incentive for legislators to switch parties lies in their desire to be re-elected. While some scholars attribute defection to the legislators’ popularity and strong connections with their constituents which enable them to be re-elected without relying on party labels, others assert that legislators switch if they perceive that staying put might threaten their chances of re-election. In this paper, we find that the two assumptions, to some extent, contradict each other. More surprisingly, the two contradictory hypotheses cohabit under the single non-transferable vote (SNTV) system. From an analysis of the switching in the Taiwanese Legislative Yuan, the empirical evidence shows that because of fierce intraparty competition in the multimember districts, not only barely elected but also top-ranked legislators switched party affiliation in order to avoid the loss in votes or even seats to their copartisans and to maximize their chances of re-election.
Becoming a Wealth Management Centre and International Relations Implications: The Singapore Policy Approach and Global and Regional Responses
Authors: AUSTIN IAN PATRICK 
Published: October 2015

AbstractSingapore's strategic play to secure international wealth management market share has been very successful. Serious questions, however, were raised in relation to this ascendency as the Global Financial Crisis (GFC, beginning in 2007) drove the European Union (EU) and the United States of America (US) to become proactive in clamping down on tax evasion and other areas deemed by them to be undesirable within the international financial system. This paper will examine the Singapore government's decade-long growth policy of its wealth management sector, and how it has been impacted upon by international regulatory responses. Further, it examines how in stark contrast to the EU and the US, Indonesia has been far less successful in its diplomatic efforts to have Singapore address financial diplomacy issues (tax evasion and ill-gotten gains from corruption) in relation to Indonesian citizens residing in Singapore. This article will argue, however, that Singapore's less than robust response to Indonesia's constant requests for action maybe to the long-term detriment of Singapore itself.Economics is now a large part of foreign policy. (George Yeo, May 2005, then Minister for Foreign Affairs, Singapore)Singapore Inc's new growth strategy in a whole range of services from real estate as a new asset class to lifestyle, taps millionaires and billionaires who value privacy, political stability, and sensitivity to money laundering implications. (Low, 2010: 171)
An Information-Processing Model for Audiences’ Selections of	Movies
Authors: Xu Xuexin , Hao Xiaoming , Younbo Jung 
Published: October 2015

Abstract. Building on psychocognitive theories of information processing, the purpose of this study was to examine the relative impacts of qualitative bandwagon (e.g., using qualitative information such as comments and reviews) and quantitative bandwagon (e.g., using quantitative information such as view and download counts as bandwagon cues) on content selection decisions by media users. An experiment (N = 77) was conducted to investigate the contributions of the two types of bandwagon behaviors to the selections of Hollywood movies online and to identify factors moderating such bandwagon effects. The results showed that cognitive load was negatively associated with the strength of qualitative bandwagon effects, while positively associated with the strength of quantitative bandwagon effects. Although it was marginally significant, the results also showed that the impact of the quantitative bandwagon effect became stronger when individuals were less familiar with Hollywood movies. Implications with respect to tendency for choice imitation, as well as the conceptual understanding of and methodological approach to the bandwagon behaviors in movie selection, are discussed.
Guidelines for diagnostic next-generation sequencing
Authors: Matthijs Gert , Souche Erika , Alders Mariëlle , Corveleyn Anniek , Eck Sebastian , Feenstra Ilse , Race Valérie , Sistermans Erik , Sturm Marc , Weiss Marjan , Yntema Helger , Bakker Egbert , Scheffer Hans , Bauer Peter 
Published: October 2015

Abstract
We present, on behalf of EuroGentest and the European Society of Human Genetics, guidelines for the evaluation and validation of next-generation sequencing (NGS) applications for the diagnosis of genetic disorders. The work was performed by a group of laboratory geneticists and bioinformaticians, and discussed with clinical geneticists, industry and patients’ representatives, and other stakeholders in the field of human genetics. The statements that were written during the elaboration of the guidelines are presented here. The background document and full guidelines are available as supplementary material. They include many examples to assist the laboratories in the implementation of NGS and accreditation of this service. The work and ideas presented by others in guidelines that have emerged elsewhere in the course of the past few years were also considered and are acknowledged in the full text. Interestingly, a few new insights that have not been cited before have emerged during the preparation of the guidelines. The most important new feature is the presentation of a ‘rating system’ for NGS-based diagnostic tests. The guidelines and statements have been applauded by the genetic diagnostic community, and thus seem to be valuable for the harmonization and quality assurance of NGS diagnostics in Europe.
Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force
Authors: Yu Cheng-han , Rafiq Nisha Bte Mohd , Cao Fakun , Zhou Yuhuan , Krishnasamy Anitha , Biswas Kabir Hassan , Ravasio Andrea , Chen Zhongwen , Wang Yu-Hsiu , Kawauchi Keiko , Jones Gareth E. , Sheetz Michael P. 
Published: October 2015

AbstractThe turnover of integrin receptors is critical for cell migration and adhesion dynamics. Here we find that force development at integrins regulates adaptor protein recruitment and endocytosis. Using mobile RGD (Arg-Gly-Asp) ligands on supported lipid membranes (RGD membranes) and rigid RGD ligands on glass (RGD-glass), we find that matrix force-dependent integrin signals block endocytosis. Dab2, an adaptor protein of clathrin-mediated endocytosis, is not recruited to activated integrin-beta3 clusters on RGD-glass; however, it is recruited to integrin-mediated adhesions on RGD membranes. Further, when force generation is inhibited on RGD-glass, Dab2 binds to integrin-beta3 clusters. Dab2 binding to integrin-beta3 excludes other adhesion-related adaptor proteins, such as talin. The clathrin-mediated endocytic machinery combines with Dab2 to facilitate the endocytosis of RGD-integrin-beta3 clusters. From these observations, we propose that loss of traction force on ligand-bound integrin-beta3 causes recruitment of Dab2/clathrin, resulting in endocytosis of integrins.
Auditory feedback blocks memory benefits of cueing during sleep
Authors: Schreiner Thomas , Lehmann Mick , Rasch Björn 
Published: October 2015

AbstractIt is now widely accepted that re-exposure to memory cues during sleep reactivates memories and can improve later recall. However, the underlying mechanisms are still unknown. As reactivation during wakefulness renders memories sensitive to updating, it remains an intriguing question whether reactivated memories during sleep also become susceptible to incorporating further information after the cue. Here we show that the memory benefits of cueing Dutch vocabulary during sleep are in fact completely blocked when memory cues are directly followed by either correct or conflicting auditory feedback, or a pure tone. In addition, immediate (but not delayed) auditory stimulation abolishes the characteristic increases in oscillatory theta and spindle activity typically associated with successful reactivation during sleep as revealed by high-density electroencephalography. We conclude that plastic processes associated with theta and spindle oscillations occurring during a sensitive period immediately after the cue are necessary for stabilizing reactivated memory traces during sleep.
Formation of bimetallic clusters in superfluid helium nanodroplets analysed by atomic resolution electron tomography
Authors: Haberfehlner Georg , Thaler Philipp , Knez Daniel , Volk Alexander , Hofer Ferdinand , Ernst Wolfgang E. , Kothleitner Gerald 
Published: October 2015

AbstractStructure, shape and composition are the basic parameters responsible for properties of nanoscale materials, distinguishing them from their bulk counterparts. To reveal these in three dimensions at the nanoscale, electron tomography is a powerful tool. Advancing electron tomography to atomic resolution in an aberration-corrected transmission electron microscope remains challenging and has been demonstrated only a few times using strong constraints or extensive filtering. Here we demonstrate atomic resolution electron tomography on silver/gold core/shell nanoclusters grown in superfluid helium nanodroplets. We reveal morphology and composition of a cluster identifying gold- and silver-rich regions in three dimensions and we estimate atomic positions without using any prior information and with minimal filtering. The ability to get full three-dimensional information down to the atomic scale allows understanding the growth and deposition process of the nanoclusters and demonstrates an approach that may be generally applicable to all types of nanoscale materials.
Ultrafast spin exchange-coupling torque via photo-excited charge-transfer processes
Authors: Ma X. , Fang F. , Li Q. , Zhu J. , Yang Y. , Wu Y. Z. , Zhao H. B. , Lüpke G. 
Published: October 2015

AbstractOptical control of spin is of central importance in the research of ultrafast spintronic devices utilizing spin dynamics at short time scales. Recently developed optical approaches such as ultrafast demagnetization, spin-transfer and spin-orbit torques open new pathways to manipulate spin through its interaction with photon, orbit, charge or phonon. However, these processes are limited by either the long thermal recovery time or the low-temperature requirement. Here we experimentally demonstrate ultrafast coherent spin precession via optical charge-transfer processes in the exchange-coupled Fe/CoO system at room temperature. The efficiency of spin precession excitation is significantly higher and the recovery time of the exchange-coupling torque is much shorter than for the demagnetization procedure, which is desirable for fast switching. The exchange coupling is a key issue in spin valves and tunnelling junctions, and hence our findings will help promote the development of exchange-coupled device concepts for ultrafast coherent spin manipulation.
The commensal infant gut meta-mobilome as a potential reservoir for persistent multidrug resistance integrons
Authors: Ravi Anuradha , Avershina Ekaterina , Foley Steven L. , Ludvigsen Jane , Storrø Ola , Øien Torbjørn , Johnsen Roar , McCartney Anne L. , L’Abée-Lund Trine M. , Rudi Knut 
Published: October 2015

AbstractDespite the accumulating knowledge on the development and establishment of the gut microbiota, its role as a reservoir for multidrug resistance is not well understood. This study investigated the prevalence and persistence patterns of an integrase gene (int1), used as a proxy for integrons (which often carry multiple antimicrobial resistance genes), in the fecal microbiota of 147 mothers and their children sampled longitudinally from birth to 2 years. The study showed the int1 gene was detected in 15% of the study population and apparently more persistent than the microbial community structure itself. We found int1 to be persistent throughout the first two years of life, as well as between mothers and their 2-year-old children. Metagenome sequencing revealed integrons in the gut meta-mobilome that were associated with plasmids and multidrug resistance. In conclusion, the persistent nature of integrons in the infant gut microbiota makes it a potential reservoir of mobile multidrug resistance.
In-vitro Optimization of Nanoparticle-Cell Labeling Protocols for In-vivo Cell Tracking Applications
Authors: Betzer Oshra , Meir Rinat , Dreifuss Tamar , Shamalov Katerina , Motiei Menachem , Shwartz Amit , Baranes Koby , Cohen Cyrille J. , Shraga-Heled Niva , Ofir Racheli , Yadid Gal , Popovtzer Rachela 
Published: October 2015

AbstractRecent advances in theranostic nanomedicine can promote stem cell and immune cell-based therapy. Gold nanoparticles (GNPs) have been shown to be promising agents for in-vivo cell-tracking in cell-based therapy applications. Yet a crucial challenge is to develop a reliable protocol for cell upload with, on the one hand, sufficient nanoparticles to achieve maximum visibility of cells, while on the other hand, assuring minimal effect of particles on cell function and viability. Previous studies have demonstrated that the physicochemical parameters of GNPs have a critical impact on their efficient uptake by cells. In the current study we have examined possible variations in GNP uptake, resulting from different incubation period and concentrations in different cell-lines. We have found that GNPs effectively labeled three different cell-lines - stem, immune and cancer cells, with minimal impairment to cell viability and functionality. We further found that uptake efficiency of GNPs into cells stabilized after a short period of time, while GNP concentration had a significant impact on cellular uptake, revealing cell-dependent differences. Our results suggest that while heeding the slight variations within cell lines, modifying the loading time and concentration of GNPs, can promote cell visibility in various nanoparticle-dependent in-vivo cell tracking and imaging applications.
Fluorescence-Guided Probes of Aptamer-Targeted Gold Nanoparticles with Computed Tomography Imaging Accesses for in Vivo Tumor Resection
Authors: Li Cheng-Hung , Kuo Tsung-Rong , Su Hsin-Jan , Lai Wei-Yun , Yang Pan-Chyr , Chen Jinn-Shiun , Wang Di-Yan , Wu Yi-Chun , Chen Chia-Chun 
Published: October 2015

AbstractRecent development of molecular imaging probes for fluorescence-guided surgery has shown great progresses for determining tumor margin to execute the tissue resection. Here we synthesize the fluorescent gold nanoparticles conjugated with diatrizoic acid and nucleolin-targeted AS1411 aptamer. The nanoparticle conjugates exhibit high water-solubility, good biocompatibility, visible fluorescence and strong X-ray attenuation for computed tomography (CT) contrast enhancement. The fluorescent nanoparticle conjugates are applied as a molecular contrast agent to reveal the tumor location in CL1-5 tumor-bearing mice by CT imaging. Furthermore, the orange-red fluorescence emitting from the conjugates in the CL1-5 tumor can be easily visualized by the naked eyes. After the resection, the IVIS measurements show that the fluorescence signal of the nanoparticle conjugates in the tumor is greatly enhanced in comparison to that in the controlled experiment. Our work has shown potential application of functionalized nanoparticles as a dual-function imaging agent in clinical fluorescence-guided surgery.
Inhibition of Proteasome Activity by Low-dose Bortezomib Attenuates Angiotensin II-induced Abdominal Aortic Aneurysm in Apo E−/− Mice
Authors: Ren Hualiang , Li Fangda , Tian Cui , Nie Hao , Wang Lei , Li Hui-Hua , Zheng Yuehong 
Published: October 2015

AbstractAbdominal aortic aneurysm (AAA) is a leading cause of sudden death in aged people. Activation of ubiquitin proteasome system (UPS) plays a critical role in the protein quality control and various diseases. However, the functional role of UPS in AAA formation remains unclear. In this study, we found that the proteasome activities and subunit expressions in AAA tissues from human and angiotensin II (Ang II)-infused apolipoprotein E knockout (Apo E−/−) mice were significantly increased. To investigate the effect of proteasome activation on the AAA formation, Apo E−/− mice were cotreated with bortezomib (BTZ) (a proteasome inhibitor, 50 μg/kg, 2 times per week) and Ang II (1000 ng/kg/min) up to 28 days. Ang II infusion significantly increased the incidence and severity of AAA in Apo E−/− mice, whereas BTZ treatment markedly inhibited proteasome activities and prevented AAA formation. Furthermore, BTZ treatment significantly reduced the inflammation, inhibited the metal matrix metalloprotease activity and reversed the phenotypic SMC modulation in AAA tissue. In conclusion, these results provide a new evidence that proteasome activation plays a critical role in AAA formation through multiple mechanisms and suggest that BTZ might be a novel therapeutic target for treatment of AAA formation.
Tunable magnetocaloric effect in transition metal alloys
Authors: Belyea Dustin D. , Lucas M. S. , Michel E. , Horwath J. , Miller Casey W. 
Published: October 2015

AbstractThe unpredictability of geopolitical tensions and resulting supply chain and pricing instabilities make it imperative to explore rare earth free magnetic materials. As such, we have investigated fully transition metal based “high entropy alloys” in the context of the magnetocaloric effect. We find the NiFeCoCrPdx family exhibits a second order magnetic phase transition whose critical temperature is tunable from 100 K to well above room temperature. The system notably displays changes in the functionality of the magnetic entropy change depending on x, which leads to nearly 40% enhancement of the refrigerant capacity. A detailed statistical analysis of the universal scaling behavior provides direct evidence that heat treatment and Pd additions reduce the distribution of exchange energies in the system, leading to a more magnetically homogeneous alloy. The general implications of this work are that the parent NiFeCoCr compound can be tuned dramatically with FCC metal additives. Together with their relatively lower cost, their superior mechanical properties that aid manufacturability and their relative chemical inertness that aids product longevity, NiFeCoCr-based materials could ultimately lead to commercially viable magnetic refrigerants.
Electronic transport properties of Ir-decorated graphene
Authors: Wang Yilin , Xiao Shudong , Cai Xinghan , Bao Wenzhong , Reutt-Robey Janice , Fuhrer Michael S. 
Published: October 2015

AbstractGraphene decorated with 5d transitional metal atoms is predicted to exhibit many intriguing properties; for example iridium adatoms are proposed to induce a substantial topological gap in graphene. We extensively investigated the conductivity of single-layer graphene decorated with iridium deposited in ultra-high vacuum at low temperature (7 K) as a function of Ir concentration, carrier density, temperature and annealing conditions. Our results are consistent with the formation of Ir clusters of ~100 atoms at low temperature, with each cluster donating a single electronic charge to graphene. Annealing graphene increases the cluster size, reducing the doping and increasing the mobility. We do not observe any sign of an energy gap induced by spin-orbit coupling, possibly due to the clustering of Ir.
Forecasting magma-chamber rupture at Santorini volcano, Greece
Authors: Browning John , Drymoni Kyriaki , Gudmundsson Agust 
Published: October 2015

AbstractHow much magma needs to be added to a shallow magma chamber to cause rupture, dyke injection and a potential eruption? Models that yield reliable answers to this question are needed in order to facilitate eruption forecasting. Development of a long-lived shallow magma chamber requires periodic influx of magmas from a parental body at depth. This redistribution process does not necessarily cause an eruption but produces a net volume change that can be measured geodetically by inversion techniques. Using continuum-mechanics and fracture-mechanics principles, we calculate the amount of magma contained at shallow depth beneath Santorini volcano, Greece. We demonstrate through structural analysis of dykes exposed within the Santorini caldera, previously published data on the volume of recent eruptions and geodetic measurements of the 2011–2012 unrest period, that the measured 0.02% increase in volume of Santorini’s shallow magma chamber was associated with magmatic excess pressure increase of around 1.1 MPa. This excess pressure was high enough to bring the chamber roof close to rupture and dyke injection. For volcanoes with known typical extrusion and intrusion (dyke) volumes, the new methodology presented here makes it possible to forecast the conditions for magma-chamber failure and dyke injection at any geodetically well-monitored volcano.
High-Gain High-Field Fusion Plasma
Authors: Li Ge 
Published: October 2015

AbstractA Faraday wheel (FW)—an electric generator of constant electrical polarity that produces huge currents—could be implemented in an existing tokamak to study high-gain high-field (HGHF) fusion plasma, such as the Experimental Advanced Superconducting Tokamak (EAST). HGHF plasma can be realized in EAST by updating its pulsed-power system to compress plasma in two steps by induction fields; high gains of the Lawson trinity parameter and fusion power are both predicted by formulating the HGHF plasma. Both gain rates are faster than the decrease rate of the plasma volume. The formulation is checked by earlier ATC tests. Good agreement between theory and tests indicates that scaling to over 10 T at EAST may be possible by two-step compressions with a compression ratio of the minor radius of up to 3. These results point to a quick new path of fusion plasma study, i.e., simulating the Sun by EAST.