bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of pre-existing depression and food insecurity on the trajectory of depressive symptomatology during the COVID-19 pandemic outbreak in South Africa: A panel analysis of nationally representative South African data
Authors: Dladla-Jaca Philile , Ncama Busisiwe P. , Moodley Yoshan , Sobratee-Fajurally Nafiisa , Davids Rashieda , Ngidi Mjabuliseni Simon C. , Sutherland Catherine , Siwela Muthulisi , Mabhaudhi Tafadzwanashe , Modi Albert T. , Slotow Rob , Burns Jonathan K. , Tomita Andrew 
Published: July 2024

AbstractWe investigated the trajectory of depressive symptoms (“depression”) from the start of the COVID-19 pandemic in South Africa (March 2020) until 2021, between individuals with and without pre-pandemic depression, specifically regarding the role of food security. Our investigation used publicly available panel data (N = 6,930) from the South African National Income Dynamics Study Coronavirus Rapid Mobile Survey (SA-NIDS-CRAM from 2020–2021) on those who had also participated in the pre-pandemic South African National Income Dynamics Study (SA-NIDS, 2017) depression interview. We investigated trends in depressive symptomatology (based on a 2-item Patient Health Questionnaire) at SA-NIDS-CRAM Wave 2 (July 2020), Wave 3 (February 2021) and Wave 5 (May 2021). Generalized estimating equations (GEE) with post-estimation linear combinations of estimators were fitted to investigate the roles of pre-pandemic depression (based on 2017 SA-NIDS data) and food insecurity during the pandemic on depressive symptomatology. During the pandemic, the highest levels of depression were observed consistently among those with pre-pandemic depression and food insecurity; and were lowest among those without pre-pandemic depression and food security. Depressive symptomatology rose in nearly equal magnitude during the early phases of the pandemic in two groups: those without pre-pandemic depression but food insecure during the pandemic; as well as those with pre-pandemic depression but food secure during the pandemic. However, this dynamic changed later in the pandemic, when higher depressive symptomatology was observed in the group with both pre-pandemic depression and food insecurity, widening the gap between them from Wave 3 (adj β = 0.63, p < 0.01) to Wave 5 (adj β = 0.79, p < 0.01). Our results highlight the importance of addressing both population mental health and food insecurity, particularly at the early stages of a crisis/disaster. As we showed that mental health impact is linked to food insecurity during a pandemic, strengthening social protection measures, especially around food and nutrition, would help build resilience to crises in the long term.
Discrete superior dynamics of a generalized chaotic system
Authors: Renu  , Ashish  , Chugh Renu 
Published: July 2024

AbstractIn the past few decades, the discrete dynamics of difference maps have attained the remarkable attention of researchers owing to their incredible applications in different domains, like cryptography, secure communications, weather forecasting, traffic flow models, neural network models, and population biology. In this article, a generalized chaotic system is proposed, and superior dynamics is disclosed through fixed point analysis, time-series evolution, cobweb representation, period-doubling, period-3 window, and Lyapunov exponent properties. The comparative bifurcation and Lyapunov plots report the superior stability and chaos performance of the generalized system. It is interesting to notice that the generalized system exhibits superior dynamics due to an additional control parameter $$\beta $$
β
. Analytical and numerical simulations are used to explore the superior dynamical characteristics of the generalized system for some specific values of parameter $$\beta $$
β
. Further, it is inferred that the superiority in dynamics of the generalized system may be efficiently used for better future applications.
In Search of Living Law: How Should We Design for (Digital) Legal Interaction?
Authors: Koulu Riikka 
Published: July 2024

AbstractIn his work on human-centric design, urban theorist Christopher Alexander elaborated design patterns as a way to conceptualise and practice urban design together with its users. Alexander aspired to design “living places”, physical spaces created by the social interactions that take place there. In this article, I use this lens to uncover the “living places” of law, and what might be the “living law” that legal design patterns could capture? I explore law as a product of design, and design as an activity, an activity that produces the many material manifestations of law. These manifestations may be digital or analog, such as case files on paper or interactive online forms, courthouse architecture or institutional webpages, courtroom furniture or dispute resolution platforms. Although often overlooked in legal scholarship, such material manifestations shape legal interaction, privileging certain forms and actors over others. They reflect values and ideologies as well as legal concepts and doctrines. By thinking about law through legal design patterns, living law becomes defined through interaction. I explore this connection between spatial and material arrangements and legal interaction they manifest and enable. This analysis makes it possible to compare law’s old material manifestations with its new places and things that rely on digital technologies. This shift of focus to legal interaction enables us to ask what legal interaction is, how it should be designed, and by whom, reconceptualising the dynamics of law, technology, and design. Ultimately, legal design patterns may provide us with conceptual and methodological tools for designing user-centric justice.
Imprisonment for breach of injunctions: what is happening in the civil courts?
Authors: Hunter Caroline , Epstein Rona , Meers Jed 
Published: July 2024

AbstractDrawing on a dataset of 263 contempt of court decisions, this paper examines a widespread but under-interrogated phenomenon: imprisonment for breach of injunctions. Across a wide range of contexts – from cases involving anti-social behaviour, protest, Gypsy and Traveller communities – courts across the country are using their civil contempt of court powers to imprison individuals for breaching injunctions. As the first research to date that explicitly examines this issue, the paper falls into four parts. First, it introduces the powers to make an injunction; in section 2 the courts’ powers on committal are outlined. Section 3 introduces the dataset on which this paper is based. Finally, section 4 explores the geographical distribution of cases, sentencing decisions, and the representation of defendants in these proceedings. We identify significant disparities in the application and enforcement of injunctions, raising critical questions about legal practices, fairness and equality. We advocate for ongoing academic research in this area.
Hydraulic Properties Within the Complete Moisture Range of Hydric Soil on the Tibetan Plateau
Authors: Wang X. , Wang Z. L. , Yang W. , Liu R. 
Published: July 2024

AbstractThe Tibetan Plateau is well‐known for its expansive wetland environments. Hydric soils, a fundamental component of these environments, exhibit diverse hydraulic characteristics attributable to their varied botanical and mineralogical composition and their inherent porous structures. Nonetheless, research on the hydraulic properties of such soils in Tibet remains notably underrepresented relative to European and Canadian regions. Consequently, in this study, we evaluate the effectiveness of different unsaturated hydraulic schemes in equilibrium and examine the parameter uncertainty of 14 undisturbed samples collected from four soligenous wetlands. The findings suggest that both the van Genuchten and Kosugi functions, when integrated with the Peters‐Iden‐Durner (PDI) model, yield a nearly consistent fit to experimental observations and demonstrate strong identifiability of parameters. This indicates that the PDI model can accurately characterize hydraulic properties across the complete moisture range of hydric soils. Analysis of samples with a low clay content and no sphagnum suggests that the intertwined, twisted, and hollow residues of herbaceous vascular tissues do not create a distinct, independent macro‐pore system. Therefore, the unimodal scheme integrating the PDI model is adequate. However, for samples that exhibit nonmonotonicity of the first‐order derivative of the retention curve, such as uncompacted samples containing sphagnum or samples rich in clay, the integration of the PDI model into the bimodal scheme boosts accuracy while having almost negligible impact on identifiability. The varied observed hydraulic properties of only 14 samples underscore the necessity for extensive hydric‐soil sampling and hydraulic analysis across the expansive and varied wetland landscapes on the Tibetan Plateau.
Snapshots of Coastal Ecology Using Multiproxy Analysis Reveals Insights Into the Preservation of Swamp and Marsh Environments Since the Late Pleistocene
Authors: Fontenot Kendall , DeLong Kristine L. , Schubert Brian A. , Warny Sophie , Wallace Davin J. , Miller Carrie M. , Culver‐Miller Erin , Polito Michael J. , Reese Carl A. , Garretson Kathryn , Xu Kehui , Harley Grant L. , Obelcz Jeffrey , Moran Kelli L. , Traphagan Julian , Jones Douglas , Caporaso Alicia 
Published: July 2024

AbstractThe southeastern United States Coastal Plain ecosystem contains baldcypress (Taxodium distichum) swamps and grass‐dominated marshes. These ecosystems also occurred on the exposed continental shelf during lower sea levels but are rarely preserved due to the mechanically erosive nature of transgression and regression. Two presently marine sites on the northeastern Gulf of Mexico's continental shelf contain well‐preserved woody terrestrial sediments that were the subject of previous studies. This study continues the investigation using geochemical (δ13C, δ15N, δ34S) and palynological characteristics of these formerly terrestrial sediments to determine if swamps and/or marshes existed at the time of deposition. The first site is located ∼20 km southeast of Horn Island, Mississippi (MS) and the core has terrestrial sediments radiocarbon dated to 11,066–10,228 (2σ) calibrated years BP (early Holocene). The second site is the “Alabama Underwater Forest” located ∼13 km south of Gulf Shores, Alabama (AL) and the cores have terrestrial sediments optically stimulated luminescence dated to 63 ka (±10 ka, 2σ) to 72 ka (±16 ka, 2σ) (late Pleistocene). Geochemical results for the MS sediments indicate a swamp‐to‐freshwater marsh transitional series, whereas the AL sediments indicate a swamp‐to‐saltwater marsh transitional series, both supported by palynological results. Further exploration of the geochemical results using linear discriminant analysis, trained with published geochemical data, supports the swamp and marsh interpretations. We conclude that the near‐pristine preservation of these woody deposits is not solely due to physical mechanisms, such as rapid burial, but is also coupled with anoxia‐ and euxinia‐driven biogeochemical reactions promoting wood and woody debris preservation in swamp and marsh environments.
Accelerating Glacier Area Loss Across the Andes Since the Little Ice Age
Authors: Carrivick Jonathan L. , Davies Morwenna , Wilson Ryan , Davies Bethan J. , Gribbin Tom , King Owen , Rabatel Antoine , García Juan‐Luis , Ely Jeremy C. 
Published: July 2024

AbstractAndean glaciers are losing mass rapidly but a centennial‐scale context to those rates is lacking. Here we show the extent of >5,500 glaciers during the Little Ice Age chronozone (LIA; c. 1,400 to c. 1,850) and compute an overall area change of −25% from then to year 2000 at an average rate of −36.5 km2 yr−1 or −0.11% yr−1. Glaciers in the Tropical Andes (Peru, Bolivia) have depleted the most; median −56% of LIA area, and the fastest; median −0.16% yr−1. Up to 10 × acceleration in glacier area loss has occurred in Tropical mountain sub‐regions comparing LIA to 2,000 rates to post‐2000 rates. Regional climate controls inter‐regional variability, whereas local factors affect intra‐region glacier response time. Analyzing glacier area change by river basins and by protected areas leads us to suggest that conservation and environmental management strategies should be re‐visited as proglacial areas expand.
From inflammation to bone formation: the intricate role of neutrophils in skeletal muscle injury and traumatic heterotopic ossification
Authors: Shu Lin-Zhen , Zhang Xian-Lei , Ding Yi-Dan , Lin Hui 
Published: July 2024

AbstractNeutrophils are emerging as an important player in skeletal muscle injury and repair. Neutrophils accumulate in injured tissue, thus releasing inflammatory factors, proteases and neutrophil extracellular traps (NETs) to clear muscle debris and pathogens when skeletal muscle is damaged. During the process of muscle repair, neutrophils can promote self-renewal and angiogenesis in satellite cells. When neutrophils are abnormally overactivated, neutrophils cause collagen deposition, functional impairment of satellite cells, and damage to the skeletal muscle vascular endothelium. Heterotopic ossification (HO) refers to abnormal bone formation in soft tissue. Skeletal muscle injury is one of the main causes of traumatic HO (tHO). Neutrophils play a pivotal role in activating BMPs and TGF-β signals, thus promoting the differentiation of mesenchymal stem cells and progenitor cells into osteoblasts or osteoclasts to facilitate HO. Furthermore, NETs are specifically localized at the site of HO, thereby accelerating the formation of HO. Additionally, the overactivation of neutrophils contributes to the disruption of immune homeostasis to trigger HO. An understanding of the diverse roles of neutrophils will not only provide more information on the pathogenesis of skeletal muscle injury for repair and HO but also provides a foundation for the development of more efficacious treatment modalities for HO.
Time-of-flight resolved stimulated Raman scattering microscopy using counter-propagating ultraslow Bessel light bullets generation
Authors: Lin Shulang , Gong Li , Huang Zhiwei 
Published: July 2024

AbstractWe present a novel time-of-flight resolved Bessel light bullet-enabled stimulated Raman scattering (B2-SRS) microscopy for deeper tissue 3D chemical imaging with high resolution without a need for mechanical z-scanning. To accomplish the tasks, we conceive a unique method to enable optical sectioning by generating the counter-propagating pump and Stokes Bessel light bullets in the sample, in which the group velocities of the Bessel light bullets are made ultraslow (e.g., vg ≈ 0.1c) and tunable by introducing programmable angular dispersions with a spatial light modulator. We theoretically analyze the working principle of the collinear multicolor Bessel light bullet generations and velocity controls with the relative time-of-flight resolved detection for SRS 3D deep tissue imaging. We have also built the B2-SRS imaging system and present the first demonstration of B2-SRS microscopy with Bessel light bullets for 3D chemical imaging in a variety of samples (e.g., polymer bead phantoms, biological samples such as spring onion tissue and porcine brain) with high resolution. The B2-SRS technique provides a > 2-fold improvement in imaging depth in porcine brain tissue compared to conventional SRS microscopy. The method of optical sectioning in tissue using counter-propagating ultraslow Bessel light bullets developed in B2-SRS is generic and easy to perform and can be readily extended to other nonlinear optical imaging modalities to advance 3D microscopic imaging in biological and biomedical systems and beyond.
Whole-exome sequencing of individuals from an isolated population under extreme conditions implicates rare risk variants of schizophrenia
Authors: Chen Lei , Du Yang , Hu Yang , Li Xue-Song , Chen Yuewen , Cheng Yong 
Published: July 2024

AbstractSchizophrenia (SCZ), which affects approximately 1% of the world’s population, is a global public health concern. It is generally considered that the interplay between genes and the environment is important in the onset and/or development of SCZ. Although several whole-exome sequencing studies have revealed rare risk variants of SCZ, no rare coding variants have been strongly replicated. Assessing isolated populations under extreme conditions might lead to the discovery of variants with a recent origin, which are more likely to have a higher frequency than chance to reflect gene-environment interactions. Following this approach, we examined a unique cohort of Tibetans living at an average altitude above 4500 meters. Whole-exome sequencing of 47 SCZ cases and 53 controls revealed 275 potential novel risk variants and two known variants (12:46244485: A/G and 22:18905934: A/G) associated with SCZ that were found in existing databases. Only one gene (C5orf42) in the gene-based statistics surpassed the exome-wide significance in the cohort. Metascape enrichment analysis suggested that novel risk genes were strongly enriched in pathways relevant to hypoxia, neurodevelopment, and neurotransmission. Additionally, 47 new risk genes were followed up in Han sample of 279 patients with SCZ and 95 controls, only BAI2 variant appearing in one case. Our findings suggest that SCZ patients living at high altitudes may have a unique risk gene signature, which may provide additional information on the underlying biology of SCZ, which can be exploited to identify individuals at greater risk of exposure to hypoxia.
Cancer risk in individuals with polydactyly: a Swedish population-based cohort study
Authors: Wachtmeister Alexandra , Tettamanti Giorgio , Nordgren Ida , Norrby Christina , Laurell Tobias , Lu Yunxia , Skarin Nordenvall Anna , Nordgren Ann 
Published: July 2024

Abstract
Background
Polydactyly is a feature of several cancer predisposition syndromes (CPS), however, cancer risk in individuals with polydactyly is largely unknown.

Methods
We performed a matched cohort study using data from Swedish national registers. We included 6694 individuals with polydactyly, born in Sweden between 1970–2017. Polydactyly was categorised as thumb polydactyly, finger polydactyly, polydactyly+ (additional birth defects and/or intellectual disability) or isolated polydactyly. Each exposed individual was matched to 50 comparisons by sex, birth year and birth county. Associations were estimated through Cox proportional hazard models.

Findings
An increased childhood cancer risk was found in males (HR 4.24, 95% CI 2.03–8.84) and females (HR 3.32, 95% CI 1.44–7.63) with polydactyly+. Isolated polydactyly was associated with cancer in childhood (HR 1.87, 95% CI 1.05–3.33) and young adulthood (HR 2.30, 95% CI 1.17–4.50) in males but not in females. The increased cancer risk remained after exclusion of two known CPS: Down syndrome and neurofibromatosis. The highest site-specific cancer risk was observed for kidney cancer and leukaemia.

Conclusions
An increased cancer risk was found in individuals with polydactyly, especially in males and in individuals with polydactyly+. We encourage future research about polydactyly and cancer associations and emphasise the importance of clinical phenotyping.
Seasonal environmental transitions and metabolic plasticity in a sea-ice alga from an individual cell perspective
Authors: Duncan Rebecca J. , Søreide Janne E. , Nielsen Daniel A. , Varpe Øystein , Wiktor Józef , Tobin Mark J. , Pitusi Vanessa , Petrou Katherina 
Published: July 2024

AbstractSea-ice microalgae are a key source of energy and nutrient supply to polar marine food webs, particularly during spring, prior to open-water phytoplankton blooms. The nutritional quality of microalgae as a food source depends on their biomolecular (lipid:protein:carbohydrate) composition. In this study, we used synchrotron-based Fourier transform infra-red microspectroscopy (s-FTIR) to measure the biomolecular content of a dominant sea-ice taxa, Nitzschia frigida, from natural land-fast ice communities throughout the Arctic spring season. Repeated sampling over six weeks from an inner (relatively stable) and an outer (relatively dynamic) fjord site revealed high intra-specific variability in biomolecular content, elucidating the plasticity of N. frigida to adjust to the dynamic sea ice and water conditions. Environmental triggers indicating the end of productivity in the ice and onset of ice melt, including nitrogen limitation and increased water temperature, drove an increase in lipid and fatty acids stores, and a decline in protein and carbohydrate content. In the context of climate change and the predicted Atlantification of the Arctic, dynamic mixing and abrupt warmer water advection could truncate these important end-of-season environmental shifts, causing the algae to be released from the ice prior to adequate lipid storage, influencing carbon transfer through the polar marine system.
The potential climate benefits of seaweed farming in temperate waters
Authors: Bullen Cameron D. , Driscoll John , Burt Jenn , Stephens Tiffany , Hessing-Lewis Margot , Gregr Edward J. 
Published: July 2024

AbstractSeaweed farming is widely promoted as an approach to mitigating climate change despite limited data on carbon removal pathways and uncertainty around benefits and risks at operational scales. We explored the feasibility of climate change mitigation from seaweed farming by constructing five scenarios spanning a range of industry development in coastal British Columbia, Canada, a temperate region identified as highly suitable for seaweed farming. Depending on growth rates and the fate of farmed seaweed, our scenarios sequestered or avoided between 0.20 and 8.2 Tg CO2e year−1, equivalent to 0.3% and 13% of annual greenhouse gas emissions in BC, respectively. Realisation of climate benefits required seaweed-based products to replace existing, more emissions-intensive products, as marine sequestration was relatively inefficient. Such products were also key to reducing the monetary cost of climate benefits, with product values exceeding production costs in only one of the scenarios we examined. However, model estimates have large uncertainties dominated by seaweed production and emissions avoided, making these key priorities for future research. Our results show that seaweed farming could make an economically feasible contribute to Canada’s climate goals if markets for value-added seaweed based products are developed. Moreover, our model demonstrates the possibility for farmers, regulators, and researchers to accurately quantify the climate benefits of seaweed farming in their regional contexts.