bluuebunny/crossref_metadata_2025_split huggingface dataset:
Micropropagation and genetic transformation of Byblis liniflora
Authors: Coronado-Martín Alberto , Martin-Vásquez Constanza , Jáquez Marybel , Bahaji Abdellatif , Atarés Alejandro 
Published: August 2024

AbstractByblis, a small genus of carnivorous plants predominantly found in Australia, is characterized by its passive trapping mechanism and unique floral features. The chemical composition of Byblis, including identified phenylethanoid glycosides, particularly acteoside, highlights its pharmacological potential with various biological activities. In vitro culture techniques have been established for propagation, with micropropagation protocols developed for different Byblis species. However, information on genetic transformation, vital for trait modification and enhanced pharmacological interest, remains limited. This study focuses on optimizing micropropagation, adventitious regeneration, and genetic transformation methods for Byblis liniflora. Adventitious regeneration rates were highest in medium with reduced Murashige and Skoog salts (MS/10) and sucrose (3 gL−1) concentrations. Zeatin supplementation (1 mgL−1) further improved regeneration rates and bud development with 100% of regenerated root explants and 8.8 shoots per explant. Liquid MB3 medium supplemented with indole-3-acetic acid (IAA) 5 mgL−1 facilitated efficient rooting and acclimatization. The establishment of an efficient Rhizobium-mediated genetic transformation method yielded transgenic plants expressing green fluorescent protein (GFP). Molecular analysis confirmed transgene integration, marking the first successful genetic transformation in the Byblis genus. These advancements pave the way for exploring gene function and enhancing pharmacological properties, thereby broadening our understanding and utilization of carnivorous plants like Byblis.
Development and evaluation of a societal core robotic surgery accreditation curriculum for the UK
Authors: Boal Matthew W. E. , Afzal Asma , Gorard Jack , Shah Aishwarya , Tesfai Freweini , Ghamrawi Walaa , Tutton Matthew , Ahmad Jawad , Selvasekar Chelliah , Khan Jim , Francis Nader K. 
Published: August 2024

AbstractStandardised proficiency-based progression is the cornerstone of safe robotic skills acquisition, however, is currently lacking within surgical training curricula. Expert consensuses have defined a modular pathway to accredit surgeons. This study aimed to address the lack of a formal, pre-clinical core robotic skills, proficiency-based accreditation curriculum in the UK. Novice robotic participants underwent a four-day pre-clinical core robotic skills curriculum incorporating multimodal assessment. Modifiable-Global Evaluative Assessment of Robotic Skills (M-GEARS), VR-automated performance metrics (APMs) and Objective Clinical Human Reliability Analysis (OCHRA) error methodology assessed performance at the beginning and end of training. Messick’s validity concept and a curriculum evaluation model were utilised. Feedback was collated. Proficiency-based progression, benchmarking, tool validity and reliability was assessed through comparative and correlational statistical methods. Forty-seven participants were recruited. Objective assessment of VR and dry models across M-GEARS, APMs and OCHRA demonstrated significant improvements in technical skill (p < 0.001). Concurrent validity between assessment tools demonstrated strong correlation in dry and VR tasks (r = 0.64–0.92, p < 0.001). OCHRA Inter-rater reliability was excellent (r = 0.93, p < 0.001 and 81% matched error events). A benchmark was established with M-GEARS and for the curriculum at 80%. Thirty (63.82%) participants passed. Feedback was 5/5 stars on average, with 100% recommendation. Curriculum evaluation fulfilled all five domains of Messick’s validity. Core robotic surgical skills training can be objectively evaluated and benchmarked to provide accreditation in basic robotic skills. A strategy is necessary to enrol standardised curricula into national surgical training at an early stage to ensure patient safety.
Developing and validating the charismatic leadership tactics scale: evidence from multi-source questionnaire studies, cognitive and behavioral assessments and a leadership training evaluation
Authors: Maran Thomas 
Published: August 2024

AbstractCharisma in managers is a leadership vitamin that enables them to lead more effectively and improve organizational performance. However, existing questionnaire measures of leaders’ charisma suffer from several limitations, primarily that they almost exclusively assess leaders’ charisma in terms of its effects rather than the constituent behaviors, thus conflating cause and effect. Employing the signaling approach to leaders' charisma, I developed and validated the Charismatic Leadership Tactics Scale (CLTS) across ten studies to measure leaders' charisma as an exogenous variable. Scale items were derived from empirical research on distinct charismatic leadership tactics. First, I established the factorial structure and internal consistency of the CLTS with managers (Study 1) and employees (Study 2). Second, I tested the agreement between manager and employee ratings and the scale’s convergent, discriminant, and incremental validity (Studies 3, 4). Third, I demonstrated that the CLTS relate to objectively measured harismatic tactics, the cognitive abilities underlying leaders’ charisma, and the outcomes that leaders’ charisma is expected to influence (external validity; Studies 5, 6, 7). Fourth, I showed the scale’s sensitivity to change in a charisma training program for managers (Study 8). Finally, I present a cross-cultural adaptation of the CLTS with managers (Study 9) and employees (Study 10). Utilizing diverse methodologies, including cross-sectional studies, automated behavioral assessments, cognitive tests, negotiation tasks, and a quasi-experimental training evaluation, these studies establish the CLTS as a valid instrument. The CLTS matches or exceeds established charismatic leadership measures while disentangling its measurement from endogenous or conflicting influences.
Curcumin Treatment Ameliorates Hepatic Insulin Resistance Induced by Sub-chronic Oral Exposure to Cadmium LOAEL Dose via NF-κB and Nrf2 Pathways
Authors: Sarmiento-Ortega Victor Enrique , Moroni-González Diana , Diaz Alfonso , Brambila Eduardo , Treviño Samuel 
Published: August 2024

AbstractCadmium (Cd) is a global pollutant, and its accumulation in the liver causes oxidative stress, inflammation, insulin resistance (IR), and metabolic complications. This study investigated whether curcumin treatment could alleviate hepatic IR in Wistar rats exposed to sub-chronic cadmium and explored the underlying molecular pathways. Male Wistar rats were divided into a control group (standard normocaloric diet + cadmium-free water) and a cadmium group (standard normocaloric diet + drinking water with 32.5 ppm CdCl2) for 30 days. Oral glucose tolerance, insulin response, and IR were assessed using mathematical models. Liver tissue was analyzed for markers of oxidative stress, inflammation, and key regulatory pathways, including NF-κB, Nrf2, MAPKs (JNK and p38), and the IRS1-Akt pathway. We established an effective curcumin dose of 250 mg/kg for 5 days orally. Results demonstrated that after 30 days of exposure, cadmium accumulated in the liver, inducing an oxidative and inflammatory state. This was characterized by increased expression of NF-κB, JNK, and p38, along with diminished Nrf2 expression, hepatic IR, hyperglycemia, and hyperinsulinemia. Curcumin treatment effectively alleviated these metabolic disorders by restoring the balance between NF-κB and Nrf2 in the liver, modulating the MAPK pathway, and, consequently, improving oxidative and inflammatory balance. In conclusion, this study suggests that cadmium induces hepatic IR through an imbalance between NF-κB and Nrf2 signaling pathways. Curcumin treatment appears to improve these pathways, thereby ameliorating hepatic IR.
Connecting the dots: using a network approach to study the wellbeing spectrum
Authors: Landvreugd Anne , van de Weijer Margot P. , Pelt Dirk H. M. , Bartels Meike 
Published: August 2024

AbstractIn positive psychology, defining the wellbeing construct has been a challenge. We used the psychometric network approach to study the structure of wellbeing. The sample consisted of Dutch adults registered with the Netherlands Twin Register. The variables were measured through standardized surveys. The network was estimated using the Mixed Graphical Models method and least absolute shrinkage and selection operator (LASSO) regularization to limit the number of spurious edges. We estimated a network in a trimming sample (N=1343, 63% females, Mage = 53.18, SDage = 9.45) and in an estimation sample (N=726, 75% females, Mage = 45.27, SDage = 11.12) to examine its performance and accuracy. Our final network consists of a positive cluster including satisfaction with life, subjective happiness, and flourishing items, and a negative cluster including depressive symptoms, loneliness, and neuroticism items. We identified the four most central nodes: one satisfaction with life item, one neuroticism item, and two depression items. This suggests that to get a general sense of the wellbeing construct, these items would serve as most informative. The network approach clearly demonstrates the different, yet connected positive and negative clusters of wellbeing and therefore re-affirms the complex interconnectivity of wellbeing phenotypes. In addition, the network results reject the view of strictly delineated wellbeing domains. Having identified the most central nodes in the network, these can be used in futures studies with limited resources, as they are likely to be the most representative of the wellbeing spectrum.
Assessment of Human Health Risk Caused by Heavy Metals in Kiln Dust from Coal-Fired Clay Brick Factories in Türkiye
Authors: Turhan Şeref , Altuner Ergin Murat , Bakır Temel K. , Duran Celalettin , Hançerlioğulları Aybaba , Kurnaz Aslı 
Published: August 2024

AbstractHeavy metal (HM) pollution from natural processes and different anthropogenic activities pose significant human and environmental health risks because of their stability, non-degradable properties, and high toxicity. HM released into the air in the form of dust can enter the human body via ingestion, inhalation, and dermal contact. Keeping in mind the significance of estimating the risk from HM in different environments, the carcinogenic and non-carcinogenic health risks to workers caused by HM in kiln dust (KD) samples collected from coal-fired clay brick factories in the Western Black Sea Region of Türkiye were assessed for the first time in this study. The concentrations of major and minor oxides and HMs in the collected KD samples were analyzed using energy-dispersive X-ray fluorescence spectrometry. The average concentrations of Fe, Mn, Cr, Ni, V, Zn, Cu, As, Co and Pb analyzed in thirty-three KD samples were determined as 65444, 768, 251, 249, 248, 122, 60, 52, 42 and 16 mg/kg dw, respectively. The average levels of Ni, As, Cr, Co and Cu exceed the maximum contaminant levels recommended in the Turkish Regulation on Control of Soil Pollution. Carcinogenic and non-carcinogenic human health risk assessments for workers via three exposure pathways were carried out, estimating the hazard index (HI) and total carcinogenic risk (TCR) index, respectively. The HI values (< 1) revealed no possible non-carcinogenic health risk due to exposure to all HMs in the studied KD samples. The average TCR value revealed that the potential cancer risks for Ni, As, Cr, and Pb were slightly above the safe limit and required monitoring and further investigation for these HMs.
Construction materials and building techniques – Comparing anthropogenic sediments of three Middle Bronze Age sites from Hungary
Authors: Kovács Gabriella , Röpke Astrid , Anvari Jana , Fischl Klára P. , Kienlin Tobias L. , Kulcsár Gabriella , Vicze Magdolna , Pető Ákos 
Published: August 2024

AbstractThis paper compares various ‘earthen’ construction materials and building techniques from three Middle Bronze Age tell (multi-layered settlement) sites in Hungary: Százhalombatta-Földvár, Kakucs-Turján (Vatya material culture) and Borsodivánka-Marhajárás-Nagyhalom (Otomani-Füzesabony Cultural Circle (OFCC)). It employs microscopic analyses – archaeological soil micromorphology and phytolith analysis within thin sections – to examine floor, wall and fire installation materials at a high resolution. The term ‘earthen construction materials’ is used in archaeology extensively to refer to anything from soils to sediments that sometimes lack proper classification or terminology. Through a closer look at the types of materials used at the three analysed sites, we describe more clearly what comprises ‘earthen’ construction materials. Using this data, we then employ a chaîne opératoire approach to think through various stages in the sourcing and preparation of building materials. In analysing this, the paper makes visible the decisions by Bronze Age builders and discusses their possible reasons, which include environmental conditions and socially learned practices. Further, by comparing three contemporary sites within a micro-landscape, our analysis highlights that even small variations in the environment and therefore the available raw materials impact building materials and techniques, and that different groups of people can make different decisions even when facing similar environments.
Time for a change? Investigating shifts in agricultural economies and food in southern-central Norway (11th -16th c. AD)
Authors: Aniceti Veronica , Vedeler Marianne , Hufthammer Anne Karin 
Published: August 2024

AbstractCattle and, to a lesser extent, sheep/goat and pigs, were crucial components of Norway’s socio-cultural and economic dynamics in the Middle Ages. Zooarchaeological analyses of faunal samples from different urban sites reveal that changes in cattle husbandry practices occurred in Norway over the medieval period, and especially in its early phases. This is clearly demonstrated in the case of medieval Oslo, where an in-depth zooarchaeological study provides the first comprehensive review of cattle husbandry strategies. In the first centuries of the medieval period (11th -mid 12th c. AD), cattle were mainly raised for milk and meat production, while fewer young and more numerous older individuals, most of which probably oxen, were present from mid 12th -13th c. AD onwards. This hypothesis is supported by biometrical analyses of cattle postcranial bones, indicating changes in the sexual composition of cattle herds over time. Therefore, from ca. mid 12th -13th c. AD onward, cattle seem to have been more used for ploughing and, only once old, to have been culled for their meat. In turn, this evidence suggests that more arable lands had to be ploughed, especially in eastern and central Norway. Here, demographic growth and settlement expansion would have led to an increase in food demand; at the same time, more favourable climatic conditions might have contributed to an increase in the availability of arable fields. This article suggests that medieval Norwegian farming was not static as historically thought, but rather connected to wider-scale agricultural innovations characterising other parts of medieval Europe.
Industrial data ecosystems and data spaces
Authors: Möller Frederik , Jussen Ilka , Springer Virginia , Gieß Anna , Schweihoff Julia Christina , Gelhaar Joshua , Guggenberger Tobias , Otto Boris 
Published: August 2024

AbstractIndustrial data ecosystems are inter-organizational forms of cooperation emerging around sharing data. They arise from a digital infrastructure, giving data providers and data users a platform to share and (re-)use data. Data spaces are among the digital infrastructures frequently associated with data ecosystems, as they supply a shared digital space for its participants to share data in a sovereign way. Data spaces aim to close a gap in the digital infrastructure landscape, addressing concerns of organizations when sharing data, such as data misappropriation or a lack of control of shared data. They do this by implementing data sovereignty—typically through Usage Control Policies—that give data providers the means to formalize semantically and technically how data users are allowed to use their data. In this fundamentals article, we address the following issues: (1) contextualizing and demarcating data spaces and data ecosystems, (2) systematizing data spaces in the research and policy landscape, and (3) elaborating on a research agenda for Information Systems (IS) research.
Green lizards (Squamata, Lacertidae) from ?Pliocene deposits of Węże I in southern Poland, with comments on cranial features for selected lacertids
Authors: Čerňanský Andrej 
Published: August 2024

AbstractI here describe lacertids from the classic Węże I locality in southern Poland (?Pliocene deposits) based on six previously undescribed jaws: an incomplete left maxilla, two dentaries and three mandibles. These jaws collectively provide considerable data on the morphology of the maxilla, dentary, teeth, coronoid, splenial, angular, surangular and prearticular. All six jaws can be unequivocally allocated to Lacertidae and five of those are allocated to European green lizards of the Lacerta viridis group. Currently, La. viridis has regionally extinct or probably extinct status in Poland. The material from Węże I provides evidence that European green lizards had a large geographic distribution in Europe, including Poland during the ?Pliocene. One mandible fragment appears to be slightly different and is allocated to Lacertidae indet. That mandible might point to a higher taxonomic diversity of lacertids in this locality. However, that interpretation needs to be viewed with caution, because based on such limited material, individual and/or ontogenetic variation cannot be ruled out. To reveal the real taxonomic palaeodiversity of lacertids in Węże I, new and more complete cranial material is needed. In addition, this article provides insights into the comparative osteology of skulls and selected cranial elements in lacertids.
Multiscale-integrated deep learning approaches for short-term load forecasting
Authors: Yang Yang , Gao Yuchao , Wang Zijin , Li Xi’an , Zhou Hu , Wu Jinran 
Published: August 2024

AbstractAccurate short-term load forecasting (STLF) is crucial for the power system. Traditional methods generally used signal decomposition techniques for feature extraction. However, these methods are limited in extrapolation performance, and the parameter of decomposition modes needs to be preset. To end this, this paper develops a novel STLF algorithm based on multi-scale perspective decomposition. The proposed algorithm adopts the multi-scale deep neural network (MscaleDNN) to decompose load series into low- and high-frequency components. Considering outliers of load series, this paper introduces the adaptive rescaled lncosh (ARlncosh) loss to fit the distribution of load data and improve the robustness. Furthermore, the attention mechanism (ATTN) extracts the correlations between different moments. In two power load data sets from Portugal and Australia, the proposed model generates competitive forecasting results.
Analytically Confirmed Intentional Overdose of the Antidepressant Vortioxetine
Authors: Daneshmend Adam , Gould Allon , Hudson Simon , Archer John Robert Howard , Dargan Paul Ivor , Wood David Michael 
Published: August 2024

Abstract
Introduction
Vortioxetine is an antidepressant with a multimodal mechanism of action. It is used as a treatment option for patients with major depressive episodes. There have only been two previously reported non-fatal overdoses of vortioxetine; neither of these were analytically confirmed There has also been one case of serotonin syndrome potentially related to vortioxetine and two deaths where vortioxetine was detected. We report here a non-fatal analytically confirmed case of vortioxetine overdose.

Case report
A 32-year-old male presented to the emergency department (ED) 12–13 h after oral ingestion of 1,260 mg of vortioxetine and 350 mg of diazepam. A family member reported that he had been drowsy after the overdose, but his level of consciousness and observations (heart rate, blood pressure and temperature) were normal on review by the pre-hospital emergency services and on arrival to the ED. During a period of observation, he did not develop any features of serotonin syndrome or any other significant toxicity. Toxicological analysis of a blood sample taken in the ED detected vortioxetine (plasma concentration 457 ng/mL 10 h after ingestion) and sub-therapeutic concentrations of diazepam and pregabalin.

Discussion
Despite having a plasma vortioxetine concentration nearly 15-times therapeutic vortioxetine concentrations, this patient did not develop any significant toxicity. In particular he did not develop any clinical or biochemical features of serotonin toxicity that would be expected with this class of antidepressant. Additional reporting of analytically confirmed vortioxetine overdoses will allow clinicians and licensing authorities to further understand the safety of this medication in overdose.
A framework for analysis of stakeholder dynamics and value creation in industrial maintenance projects: the stakeholder ipot
Authors: Masarira Mufaro , Papadopoulou Kassandra A. , Rahbarimanesh Amir , Sinha Jyoti K. , Kumar Uday 
Published: August 2024

AbstractThis paper proposes a methodological approach that can be applied in practice for evaluating stakeholder dynamics and assessing projects against appropriate value propositions within an industrial maintenance project context. A conceptual framework is proposed and is demonstrated through a case analysis. It is expected that the proposed methodology, the Stakeholder Interdependent Performance Opportunities and Threats, (Stakeholder iPOT), can advance project management practice by offering a mechanism for analysing stakeholder expectations and responses to the opportunities and threats that different project events present. This study highlights the need for continued investigation not only within the context of industrial maintenance projects but also in other sectors to improve our understanding and ability to effectively manage stakeholder dynamics.
Jakarta groundwater modeling: a review
Authors: Nugraha Gumilar Utamas , Bakti Hendra , Lubis Racmat Fajar , Nur Andi Agus 
Published: August 2024

AbstractJakarta is the center of Indonesia’s economy and development. However, the city of Jakarta suffers from many problems related to groundwater, and good groundwater governance is needed to realize groundwater sustainability. Groundwater management can be initiated by undertaking conceptual and numerical groundwater modeling. This paper reviews several previous studies related to groundwater modeling of the Jakarta groundwater basin that have provided information about the groundwater system and groundwater quantity. However, improvements are required for any further studies. The critical challenges to providing a complete picture of the groundwater conditions in the Jakarta groundwater basin are the availability of reliable data and improved groundwater flow models.