bluuebunny/crossref_metadata_2025_split huggingface dataset:
Life as Relatio: Classical Metaphysics and Trinitarian Ontology
Authors: Maspero Giulio 
Published: May 2015

Aristotle, Metaphysics.Augustine, The Trinity.Ayres L., (Mis)Adventures in Trinitarian Ontologies, in: J. Polkinghorne (ed.), The Trinity and an Entangled World, Cambridge 2010, pp. 130–145.Bausola A., La libertà, Brescia 1990.Berti E., “Per i viventi l’essere è il vivere” (Aristotle, De anima 415.b.13), in: M. Sánchez Sorondo (ed.), La vita, Roma 1998, p. 29.Berti E., Attualità dell’eredità di Aristotele, PATH 5 (2006) p. 302–305.Daniélou J., Dieu et nous, Paris 1956.Donati P., Relational Sociology. A New Paradigm for the Social Sciences, London–New York 2011.Gregory of Nyssa, Contra Eunomium.Lafont G., Peut-on connaitre Dieu en Jésus-Christ?, Paris 1969.Maspero G., Patristic Trinitarian Ontology, in: G. Maspero, R. J. Wozniak (eds.), Rethinking Trinitarian Theology: Disputed Questions And Contemporary Issues in Trinitarian Theology, London–New York 2011.Maspero G., Remarks on the Relevance of Gregory of Nyssa’s Trinitarian Doctrine for the Epistemological Perspective of 20th Century Psychoanalysis, European Journal of Science and Theology 6 (2010) p. 17–31.Musso P., Science and the Idea of Reason, Milano–Udine 2011.Plato, Laws.Plato, Sofist.Plato, Symposium.Ratzinger J., Introduction to Christianity, San Francisco 2004.Reale G., Metafisica di Aristotele, Milano 2004.Ruiz Aldaz J.I., article Contra Eunomium III, in: L. F. Mateo-Seco, G. Maspero (eds.), The Brill Dictionary of Gregory of Nyssa, Leuven 2010, pp. 307–310.Thomas Aquinas, Disputed Questions Concerning Divine Power.Zizioulas J., Trinitarian Freedom: is God Free in Trinitarian Life?, in: G. Maspero, R. J. Wozniak (eds.), Rethinking Trinitarian Theology: Disputed Questions And Contemporary Issues in Trinitarian Theology, London–New York 2011.
Monastic Exegesis and the Biblical Typology of Monasticism in the Patristic Period
Authors: Kasprzak Dariusz 
Published: May 2015

Monastic exegesis of the Bible in the Patristic period was characterized by ascetic pragmatism, reminiscence and meditation of the canonical text and at the same time its extra-verbal literal and spiritual interpretation. The consequence of such a manner of reading the text of the Bible was to acknowledge the monastic way of life as the royal path (via regia) and the monk as the one possessing certain spiritual knowledge and living faith. Systematic ignoring of the original Hebrew text by ancient monks, as well as by the Fathers of the Church, in using literal – spiritual and anagogical exegesis led to every biblical text being understood in a spiritual manner, i.e. as a text leading a monk to salvation. The biblical typologies of the monastic life also started to be derived from the theological rule of the Testaments. Those typologies resulted from the formerly adopted Christocentric theological premise assuming that the whole Bible tells about Christ and leads to Christ. They were the spiritual interpretation of the biblical text and were aimed at accounting for monasticism as the biblical form of life.
Diastolic Dysfunction Occurs Early in HER2-Positive Breast Cancer Patients Treated Concurrently With Radiation Therapy and Trastuzumab
Authors: Cao Lu , Cai Gang , Chang Cai , Miao Ai-Yu , Yu Xiao-Li , Yang Zhao-Zhi , Ma Jin-Li , Zhang Qian , Wu Jiong , Guo Xiao-Mao , Chen Jia-Yi 
Published: May 2015

AbstractBackground.Left ventricular ejection fraction (LVEF) is used routinely to monitor cardiac dysfunction associated with breast cancer treatment. In this study the prevalence of early left ventricular diastolic dysfunction (LVDD) and its relationship to the dose-volume of the heart irradiated were evaluated in HER2-positive breast cancer patients undergoing concurrent trastuzumab and adjuvant radiotherapy (RT).Materials and Methods.Data from 40 breast cancer patients treated with concurrent trastuzumab and left-sided adjuvant RT between September 2011 and October 2012 were collected prospectively. For comparison, 32 patients treated with concurrent trastuzumab and right-sided adjuvant RT and 71 patients treated with left-sided RT alone were collected retrospectively. Echocardiography was obtained before RT, immediately following RT, and 3 and 6 months after RT. Doses to the heart and left ventricle (LV) were quantified.Results.Prior to RT with concurrent trastuzumab, 11 of 29 (left) and 8 of 25 (right) patients with normal baseline left ventricular diastolic function (LVDF) developed LVDD. In patients receiving left-sided RT alone, 12 of 61 patients with normal baseline LVDF developed LVDD. Dmean, D15–D40, D60–D70, and V3–V10 of the LV were significantly higher in patients who developed LVDD after concurrent trastuzumab and left-sided RT. In contrast, only two patients developed grade 1 LVEF decrease after both concurrent treatment and left-sided RT alone.Conclusion.Changes in LVDF compared with LVEF are more sensitive for early detection of cardiotoxicity. The dose-volume of the heart contributes significantly to the risk of LVDD in patients with left-sided breast cancer treated concurrently with trastuzumab.Implications for Practice:Abnormalities in diastolic function are more sensitive than changes in the left ventricular ejection fraction for detecting acute cardiotoxicity and are related to the dose-volume of the heart irradiated in patients with left-sided breast cancer receiving radiotherapy concurrently with trastuzumab. This result highlights the importance of decreasing the dose-volume of heart irradiated as a protective strategy in the treatment setting of concurrent trastuzumab and radiotherapy. Diastolic dysfunction may serve as a more sensitive tool for the early detection of cardiac damage and should be incorporated as a routine parameter in the functional monitoring of cardiotoxicity.
Symptoms and Symptom Attribution Among Women on Endocrine Therapy for Breast Cancer
Authors: Rosenberg Shoshana M. , Stanton Annette L. , Petrie Keith J. , Partridge Ann H. 
Published: May 2015

Abstract

Background.
Adherence to adjuvant endocrine therapy (ET) influences breast cancer survival. Because ET side effects are frequently cited as reasons for nonadherence, understanding how perceptions and motivations in relation to ET are associated with symptom attribution can help promote timely symptom management.

Materials and Methods.
Participants were 2,086 breast cancer survivors recruited through the Army of Women registry who were current tamoxifen or aromatase inhibitor (AI) users. Participants reported whether they were bothered by each of 47 symptoms during the past month and whether they thought each symptom was related to taking ET. Frequencies of overall symptoms and symptoms attributed and misattributed to ET were calculated, and linear regression was used to assess sociodemographics, emotions, and illness perceptions as predictors of symptoms attributed to ET.

Results.
Women attributed a mean of 8.9 symptoms and misattributed a mean of 1.5 symptoms to ET. In the multivariable analysis, younger age, a more recent diagnosis, AI use (vs. tamoxifen), anxiety, depressive symptoms, more ET-related negative emotions, more concern about long-term ET use, and greater perceived ET necessity were independently associated with attribution of more symptoms to ET. More perceived ET necessity was associated with correctly attributing symptoms to ET, whereas higher depressive symptoms and more concern about ET use were associated with misattribution of symptoms to ET.

Conclusion.
Given that many women perceive a range of symptoms as a consequence of ET, attention to these symptoms may reduce symptom burden and improve quality of life, potentially improving ET adherence and optimizing survival.

Implications for Practice:
Many breast cancer survivors on endocrine therapy (ET) experience a range of side effects while taking ET. Targeting potentially modifiable factors associated with attributing a greater number of symptoms to ET, including perceived need for ET, concerns about long-term ET use, negative emotions toward ET, and symptoms of anxiety and depression, may reduce symptom burden and improve quality of life.
Frequency, Predictors, and Medical Record Documentation of Chemical Coping Among Advanced Cancer Patients
Authors: Kwon Jung Hye , Tanco Kimberson , Park Ji Chan , Wong Angelique , Seo Lisa , Liu Diane , Chisholm Gary , Williams Janet , Hui David , Bruera Eduardo 
Published: May 2015

Abstract

Background.
In this prospective study, we determined the frequency of opioid-related chemical coping among advanced cancer patients, as diagnosed by palliative medicine specialists. We also determined predictors for chemical coping and the concordance between the physician's diagnosis and documentation in the medical records.

Patients and Methods.
Palliative medicine specialists evaluated and diagnosed consecutive patients seen for chemical coping. The proportion of patients identified as chemically coping was compared with the proportion documented in the medical records. Demographic data; cancer diagnosis; history of smoking; substance abuse; psychiatric disease; morphine equivalent daily dosage; Cut-down, Annoyed, Guilty, and Eye-opener (CAGE) questionnaire scores; and Edmonton Symptom Assessment System scores were also collected.

Results.
A total of 432 patients were evaluated. Overall, 76 patients (18%; 95% confidence interval [CI]: 14%–21%) were diagnosed as chemically coping. Documentation of chemical coping in the medical records was reported for only 15 patients (4%; 95% CI: 2%–6%). CAGE positivity (odds ratio [OR]: 2.89), younger age (OR: 0.97 per year), better performance status (OR: 0.68 per point), pain (OR: 1.20 per point), and well-being (OR: 1.28 per point) were found to be significant predictors of chemical coping by protocol definition. After recursive partitioning, 21 of 50 patients (42%) who were CAGE positive and had an Eastern Cooperative Oncology Group performance status ≤2 were diagnosed as chemically coping.

Conclusion.
Approximately 18% of palliative care patients seen were diagnosed as chemically coping by palliative medicine specialists. The frequency of documentation in the medical records was significantly lower. Better and safer ways for physicians to assess and report chemical coping are needed.

Implications for Practice:
Cancer pain is a multidimensional symptom for which opioids are the mainstay of treatment. However, opioids can have a double effect resulting in drug-seeking behaviors. Chemical coping occurs when a patient uses opioids in a nonprescribed way to cope with various stressful events. This can lead to misuse of opioids and complications including neurotoxicities, respiratory depression, and death. Proper diagnosis and documentation is needed to ensure proper management of pain and to avoid unnecessary harm. The findings of this study suggest that ∼18% of advanced cancer patients seen by a palliative care service were diagnosed as chemical coping, but only 4% were documented in the medical records.
Falls Associated with Muscle Strength in Patients with Knee Osteoarthritis and Self-reported Knee Instability
Authors: de Zwart Arjan H. , van der Esch Martin , Pijnappels Mirjam A.G.M. , Hoozemans Marco J.M. , van der Leeden Marike , Roorda Leo D. , Dekker Joost , Lems Willem F. , van Dieën Jaap H. 
Published: May 2015

Objective.We aimed to evaluate the associations between knee muscle strength (MS) and falls, controlling for knee joint proprioception, varus-valgus knee joint laxity, and knee pain, among patients with knee osteoarthritis (OA) reporting knee instability.Methods.A sample of 301 subjects (203 women, 98 men, 35–82 yrs) with established knee OA and self-reported knee instability was studied. The occurrence of at least 1 fall in the previous 3 months was assessed by questionnaire. Maximum knee extension and flexion strength were measured isokinetically. Additionally, proprioception, varus-valgus laxity, and pain were assessed. Student t tests were used to assess differences between subgroups. The association of muscle strength and falls was calculated using univariate and multivariate logistic regression analysis.Results.Over 10% of the subjects (31 out of 301) reported a fall in the previous 3 months. High knee extension muscle strength (crude OR 0.3, 95% CI 0.1–0.8, p = 0.022) and high knee flexion muscle strength (crude OR 0.2, 95% CI 0.0–1.0, p = 0.048) were associated with a lower risk of falls. Proprioception and laxity did not confound this relationship. After adjusting for pain, extensor strength had an adjusted OR of 0.5 (95% CI 0.2–1.4, p = 0.212) for falls and flexor strength had an adjusted OR of 0.4 (95% CI 0.1–2.3, p = 0.312).Conclusion.High knee extension and flexion muscle strength decreased the risk of falls in patients with knee OA and self-reported knee instability. After considering the effect of pain, there was insufficient statistical power to detect an association between muscle strength and falls, which might be because of the low number of subjects who fell (n = 31).
Erectile Dysfunction Is Common among Patients with Gout
Authors: Schlesinger Naomi , Radvanski Diane C. , Cheng Jerry Q. , Kostis John B. 
Published: May 2015

Objective.To determine whether men with gout may have an increased prevalence of erectile dysfunction (ED) as compared with men without gout.Methods.In this cross-sectional study, men aged 18–89 presenting to the rheumatology clinic between August 26, 2010, and May 13, 2013, were asked to participate. The presence of ED was determined by the Sexual Health Inventory in Men (SHIM). SHIM classifies ED into 1 of 5 categories: absent (22–25), mild (17–21), mild to moderate (12–16), moderate (8–11), and severe (1–7). Patient’s history, physical examination, and recent laboratory studies were reviewed as well. Descriptive statistics and subgroup analyses were used to summarize the data.Results.Of the 201 men surveyed, 83 had gout (control, n = 118). A significantly greater proportion of patients with gout (63, 76%) had ED versus patients without gout (60, 51%, p = 0.0003). A significantly greater proportion of patients with gout (22, 26%) had severe ED versus patients without gout (17, 15%, p = 0.04). Patients with gout had an average SHIM score of 14.4 versus 18.48 in patients without gout (p < 0.0001). There was a statistically significant association between gout and ED. The association remained significant after adjustment for age, hypertension, diabetes, and obesity.Conclusion.ED is present in most men with gout and is frequently severe. We propose that patients with gout be routinely screened for ED.
Enhanced Patient Involvement and the Need to Revise the Core Set — Report from the Psoriatic Arthritis Working Group at OMERACT 2014
Authors: Tillett William , Eder Lihi , Goel Niti , De Wit Maarten , Gladman Dafna D. , FitzGerald Oliver , Campbell Willemina , Helliwell Philip S. , Gossec Laure , Orbai Ana-Maria , Ogdie Alexis , Strand Vibeke , McHugh Neil J. , Mease Philip J. 
Published: May 2015

Objective.To discuss the need for revision of the “core set” of domains to be included for assessment in psoriatic arthritis (PsA) randomized controlled trials and longitudinal observational studies, review work undertaken since the 2012 meeting of Outcome Measures for Rheumatology 11 (OMERACT 11) to include patient perspectives in this revision, and reassess proposed composite measures in the context of new research data and the OMERACT Filter 2.0 framework.Methods.The OMERACT 12 (2014) PsA working group presented work completed over the last 2 years to incorporate patient involvement in PsA outcomes research, review the endorsed PsA core set based on the patient perspective as well as new research findings, and further develop PsA responder indices. Breakout groups then discussed 2 topics: (1) the need to revise the PsA core set, and opportunities to add, move, or merge existing domains to improve existing redundancy; and (2) how to incorporate the core set in a composite index. Breakout groups fed back to the working group before participant voting.Results.Meeting participants endorsed the need to revise the PsA core set according to the OMERACT Filter 2.0 framework (100%), and the inclusion of disease impact (94%) and fatigue (72%) in the inner circle. Breakout group feedback suggested the core set revision was an opportunity to consolidate pathophysiologic aspects such as arthritis, enthesitis, dactylitis, spondylitis as “inflammatory musculoskeletal disease,” and nail and skin psoriasis as “psoriasis activity.”Conclusion.Future work will focus on updating the PsA core set and development of responder indices with ongoing, meaningful involvement of patient research partners.
Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor-β1 toward Fibroblast-like Synovial Cells
Authors: Suzuki Takahisa , Iwamoto Naoki , Yamasaki Satoshi , Nishino Ayako , Nakashima Yoshikazu , Horai Yoshiro , Kawashiri Shin-ya , Ichinose Kunihiro , Arima Kazuhiko , Tamai Mami , Nakamura Hideki , Origuchi Tomoki , Miyamoto Chikara , Osaki Makoto , Ohyama Kaname , Kuroda Naotaka , Kawakami Atsushi 
Published: May 2015

Objective.To investigate the role of thrombospondin 1 (TSP-1) in RA.Methods.Expression of TSP-1 in synovial tissues was determined by immunohistochemistry. Expression of TSP-1 in rheumatoid fibroblast-like synovial cells (FLS) was investigated by quantitative real-time PCR and ELISA. Correlations among the plasma TSP-1 and other variables in patients with RA were examined.Results.Expression of TSP-1 was increased in rheumatoid synovial tissues. Transforming growth factor-β1 (TGF-β1) clearly increased TSP-1 expression in FLS on both mRNA and protein levels. Changes in plasma TSP-1 were associated with those in 28-joint Disease Activity Score-erythrocyte sedimentation rate and plasma TGF-β1.Conclusion.TSP-1 might be critically involved in the disease process of RA through the TGF-β1/TSP-1 axis.
Nanotubes Connect CD4+ T Cells to Airway Smooth Muscle Cells: Novel Mechanism of T Cell Survival
Authors: Al Heialy Saba , Zeroual Melissa , Farahnak Soroor , McGovern Toby , Risse Paul-André , Novali Mauro , Lauzon Anne-Marie , Roman Horia N. , Martin James G. 
Published: May 2015

AbstractContact between airway smooth muscle (ASM) cells and activated CD4+ T cells, a key interaction in diseases such as asthma, triggers ASM cell proliferation and enhances T cell survival. We hypothesized that direct contact between ASM and CD4+ T cells facilitated the transfer of anti-apoptotic proteins via nanotubes, resulting in increased survival of activated CD4+ T cells. CD4+ T cells, isolated from PBMCs of healthy subjects, when activated and cocultured with ASM cells for 24 h, formed nanotubes that were visualized by immunofluorescence and atomic force microscopy. Cell-to-cell transfer of the fluorescent dye calcein-AM confirmed cytoplasmic communication via nanotubes. Immunoreactive B cell lymphoma 2 (Bcl-2) and induced myeloid leukemia cell differentiation protein (Mcl-1), two major anti-apoptotic proteins, were present within the nanotubes. Downregulation of Mcl-1 by small interfering RNA in ASM cells significantly increased T cell apoptosis, whereas downregulation of Bcl-2 had no effect. Transfer of GFP-tagged Mcl-1 from ASM cells to CD4+ T cells via the nanotubes confirmed directionality of transfer. In conclusion, activated T cells communicate with ASM cells via nanotube formation. Direct transfer of Mcl-1 from ASM to CD+ T cells via nanotubes is involved in T cell survival. This study provides a novel mechanism of survival of CD4+ T cells that is dependent on interaction with a structural cell.
Transcription Factors STAT6 and KLF4 Implement Macrophage Polarization via the Dual Catalytic Powers of MCPIP
Authors: Kapoor Nidhi , Niu Jianli , Saad Yasser , Kumar Sanjay , Sirakova Tatiana , Becerra Edilu , Li Xiaoman , Kolattukudy Pappachan E. 
Published: May 2015

Abstract
Macrophage polarization plays a critical role in tissue homeostasis, disease pathogenesis, and inflammation and its resolution. IL-4–induced macrophage polarization involves induction of STAT6 and Krüppel-like factor 4 (KLF4), which induce each other and promote M2 polarization. However, how these transcription factors implement M2 polarization is not understood. We report that in murine macrophages MCP-1–induced protein (MCPIP), induced by KLF4, inhibits M1 polarization by inhibiting NF-κB activation and implements M2 polarization using both its deubiquitinase and RNase activities that cause sequential induction of reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, and autophagy required for M2 polarization. MCPIP also induces C/EBPβ and PPARγ, which promote M2 polarization. Macrophages from mice with myeloid-targeted overexpression of MCPIP show elevated expression of M2 markers and reduced response to LPS, whereas macrophages from mice with myeloid-specific deletion of MCPIP manifest elevated M1 polarization with enhanced phagocytic activity. Thus, both in vivo and in vitro experiments demonstrate that the transcription factors STAT6 and KLF4 implement IL-4–induced M2 polarization via the dual catalytic activities of MCPIP.
Existence of mandibular directional asymmetry in the European wild boar (Sus scrofa Linnaeus, 1758)
Authors: Parés-Casanova P. 
Published: May 2015

Abstract
Introduction and material and methods. We studied a sample of 37 dentulous dry mandibles from European wild board (Sus scrofa) and compared both the right and left sides in their dorsal aspect. To study the influence of age, the samples were grouped according to dental status: “subadults” (erupting 3rd M, n=22) and “adults” (fully erupted 3rd M, n=15). Individual levels of asymmetry were analysed from x- and y-coordinates of the 16 landmarks on the dorsal aspect of the mandible. Results. The analysis separated directional asymmetry (one side of the body with a larger character value than the other) and fluctuating asymmetry (small random deviations from perfect symmetry), which were both found to be significant. Conclusion. The condylar ramus was the most asymmetric structure for both age groups.
What Have Economists Been Doing for the Last 50 Years? A Text Analysis of Published Academic Research from 1960–2010
Authors: Kosnik Lea-Rachel 
Published: May 2015

Abstract
This paper presents the results of a text based exploratory study of over 20,000 academic articles published in seven top research journals from 1960–2010. The goal is to investigate the general research foci of economists over the last fifty years, how (if at all) they have changed over time, and what trends (if any) can be discerned from a broad body of the top academic research in the field. Of the 19 JEL-code based fields studied in the literature, most have retained a constant level of attention over the time period of this study, however, a notable exception is that of macroeconomics which has undergone a significantly diminishing level of research attention in the last couple of decades, across all the journals under study; at the same time, the “microfoundations” of macroeconomic papers appears to be increasing. Other results on co-authorship trends and depth of research articles are also presented.