bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modest forest and welfare gains from initiatives for reduced emissions from deforestation and forest degradation
Authors: Wunder Sven , Schulz Dario , Montoya-Zumaeta Javier G. , Börner Jan , Ponzoni Frey Gabriel , Betancur-Corredor Bibiana 
Published: July 2024

AbstractReduced emissions from deforestation and forest degradation (REDD+) projects and programmes promise to deliver performance-based, cost-effective climate change mitigation. Fifteen years after its conception, we analysed the rigorous counterfactual-based evidence for environmental and welfare effects from such national and subnational initiatives, along with a Theory of Change. Using machine-learning tools for literature review, we compared 32 quantitative studies including 26 primary forest-related and 12 socioeconomic effect sizes. Average environmental impacts were positively significant yet moderately sized, comparable to impacts from other conservation tools, and mostly impermanent over time. Socioeconomic impacts were welfare-neutral to slightly positive. Moderator analysis showed that environmental additionality was likely restricted by project proponents’ adverse spatial targeting of low-threat areas. Scarce funding flows from carbon markets and ill-enforced conditionality probably also limited impacts. Hence, important policy and implementation lessons emerge for boosting effectiveness in the current global transition towards larger-scale, jurisdictional action.
Coordinating limbs and spine: (Pareto-)optimal locomotion in theory, in vivo, and in robots
Authors: Rockenfeller Robert , Cieri Robert L. , Schultz Johanna T. , Maag Robin , Clemente Christofer J. 
Published: July 2024

AbstractAmong vertebrates, patterns of movement vary considerably, from the lateral spine-based movements of fish and salamanders to the predominantly limb-based movements of mammals. Yet, we know little about why these changes may have occurred in the course of evolution. Lizards form an interesting intermediate group where locomotion appears to be driven by both motion of their limbs and lateral spinal undulation. To understand the evolution and relative advantages of limb versus spine locomotion, we developed an empirically informed mathematical model as well as a robotic model and compared in silico predictions to in-vivo data from running and climbing lizards. Our mathematical model showed that, if limbs were allowed to grow to long lengths, movements of the spine did not enable longer strides, since spinal movements reduced the achievable range of motion of the limbs before collision. Yet, in-vivo data show lateral spine movement is widespread among a diverse group of lizards moving on level ground or climbing up and down surfaces. Our climbing robotic model was able to explain this disparity, showing that increased movement of the spine was energetically favourable, being associated with a reduced cost of transport. Our robot model also revealed that stability, as another performance criterion, decreased with increased spine and limb range of motion—detailing the trade-off between speed and stability. Overall, our robotic model found a Pareto-optimal set of strides—when considering speed, efficiency, and stability—requiring both spine and limb movement, which closely agreed with movement patterns among lizards. Thus we demonstrate how robotic models, in combination with theoretical considerations, can reveal fundamental insights into the evolution of movement strategies among a broad range of taxa.
Finishing the odyssey to a stem cell cure for type 1 diabetes
Authors: Hunault Lise , Hesselson Daniel 
Published: July 2024

AbstractFor over two decades pluripotent stem cells have promised a renewable source of β cells to treat patients with type 1 diabetes. Major efforts to optimize the differentiation, survival, and function of transplanted stem cell-derived tissue have recently delivered clinically meaningful metabolic benefits using a perforated encapsulation device that promotes integration with recipient vasculature under the protection of systemic immunosuppression. Despite this success, the journey is not over as a universal cure will require a larger β cell mass. Here, we summarize recent interdisciplinary advances that could maximize the functional β cell mass within transplanted devices and provide an immune privileged niche that could eliminate the need for systemic immunosuppression.
Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase
Authors: Tengbom John , Kontidou Eftychia , Collado Aida , Yang Jiangning , Alvarsson Michael , Brinck Jonas , Rössner Sophia , Zhou Zhichao , Pernow John , Mahdi Ali 
Published: July 2024

Abstract
The mechanisms underlying endothelial dysfunction in Type 1 and Type 2 diabetes (T1DM and T2DM) are unresolved. The red blood cells (RBCs) with increased arginase activity induce endothelial dysfunction in T2DM, but the implications of RBCs and the role of arginase inhibition in T1DM are unexplored. We aimed to investigate the differences in endothelial function in patients with T1DM and T2DM, with focus on RBCs and arginase. Thirteen patients with T1DM and twenty-six patients with T2DM, matched for HbA1c and sex were included. In vivo endothelium-dependent and -independent vasodilation (EDV and EIDV) were assessed by venous occlusion plethysmography before and after administration of an arginase inhibitor. RBCs were co-incubated with rat aortic segments for 18h followed by evaluation of endothelium-dependent (EDR) and -independent relaxation (EIDR) in isolated organ chambers. In vivo EDV, but not EIDV, was significantly impaired in patients with T2DM compared with patients with T1DM. Arginase inhibition resulted in improved EDV only in T2DM. RBCs from patients with T2DM induced impaired EDR but not EIDR in isolated aortic segments, whereas RBCs from patients with T1DM did not affect EDR nor EIDR. The present study demonstrates markedly impaired EDV in patients with T2DM in comparison with T1DM. In addition, it highlights the divergent roles of RBCs and arginase in mediating endothelial dysfunction in T1DM and T2DM. While endothelial dysfunction is mediated via RBCs and arginase in T2DM, these phenomena are not prominent in T1DM thereby indicating distinct differences in underlying mechanisms.
Convex equilibrium‐free stability and performance analysis of discrete‐time nonlinear systems
Authors: Koelewijn Patrick J. W. , Weiland Siep , Tóth Roland 
Published: July 2024

AbstractThis paper considers the equilibrium‐free stability and performance analysis of discrete‐time nonlinear systems. Two types of equilibrium‐free notions are considered. Namely, the universal shifted concept, which considers stability and performance w.r.t. all equilibrium points of the system, and the incremental concept, which considers stability and performance between trajectories of the system. This paper shows how universal shifted stability and performance of discrete‐time systems can be analysed by making use of the time‐difference dynamics. Moreover, the existing results are extended for incremental dissipativity for discrete‐time systems based on dissipativity analysis of the differential dynamics to more general state‐dependent storage functions for less conservative results. Finally, it is shown how both these equilibrium‐free notions can be cast as a convex analysis problem by making use of the linear parameter‐varying framework, which is also demonstrated by means of an example.
Memory‐based event‐triggered control for networked control system under cyber‐attacks
Authors: Nafir Noureddine , Khemissat Abdel Mouneim , Farrag Mohamed Emad , Rouamel Mohamed 
Published: July 2024

AbstractThis article focuses on the problem of stability for a class of linear networked control systems (NCSs) subjected to network communication delays and random deception attacks. A new memory event‐triggered mechanism (METM) is proposed to reduce the unnecessary transmitted data through the communication channel and then enhance the network resources. In this context, a new memory stochastic state feedback controller is proposed to stabilize the closed‐loop networked control system. A new randomly occurring deception attacks model is employed to deal with the security problem of NCSs. Sufficient stability conditions are derived based on a suitable Lyapunov‐Krasovskii functional (LKF). The designed methodology is proposed in terms of linear matrix inequality to synthesize both event‐triggered parameters and controller gains, and to reduce the conservatism of the system some integral lemma are exploited to bind the time derivative of the LKF. Finally, two numerical examples are presented to illustrate the effectiveness of the proposed method which provides a maximal upper bound value of the network‐induced delay and less transmitted packet regarding the maximal value delay obtained in other works, so less conservatism results are obtained, compared to previous ones in the literature.
Real‐time fire and smoke detection with transfer learning based on cloud‐edge collaborative architecture
Authors: Yang Ming , Qian Songrong , Wu Xiaoqin 
Published: July 2024

AbstractRecent years have seen increased interest in object detection‐based applications for fire detection in digital images and videos from edge devices. The environment's complexity and variability often lead to interference from factors such as fire and smoke characteristics, background noise, and camera settings like angle, sharpness, and exposure, which hampers the effectiveness of fire detection applications. Limited picture data for fire and smoke scenes further challenges model accuracy and robustness, resulting in high false detection and leakage rates. To address the need for efficient detection and adaptability to various environments, this paper focuses on (1) proposing a cloud‐edge collaborative architecture for real‐time fire and smoke detection, incorporating an iterative transfer learning strategy based on user feedback to enhance adaptability; (2) improving the detection capabilities of the base model YOLOv8 by enhancing the data augmentation method and introducing the coordinate attention mechanism to improve global feature extraction. The improved algorithm shows a 2‐point accuracy increase. After three iterations of transfer learning in the production environment, accuracy improves from 93.3% to 96.4%, and mAP0.5:0.95 increases by nearly 5 points. This program effectively addresses false detection issues in fire and smoke detection systems, demonstrating practical applicability.
Prevalence and prognostic role of thoracic lymphadenopathy in Covid-19
Authors:   Autorinnen/Autoren,   RACOON Study Group
Published: July 2024

Purpose The prevalent coronavirus disease 2019 (COVID-19) pandemic has spread throughout the world and is considered a serious threat to global health. The prognostic role of thoracic lymphadenopathy in COVID-19 is unclear. The aim of the present meta-analysis was to analyze the prognostic role of thoracic lymphadenopathy for the prediction of 30-day mortality in patients with COVID-19.
Materials and Methods The MEDLINE library, Cochrane, and SCOPUS databases were screened for associations between CT-defined features and mortality in COVID-19 patients up to June 2021. In total, 21 studies were included in the present analysis. The quality of the included studies was assessed by the Newcastle-Ottawa Scale. The meta-analysis was performed using RevMan 5.3. Heterogeneity was calculated by means of the inconsistency index I2. DerSimonian and Laird random-effect models with inverse variance weights were performed without any further correction.
Results The included studies comprised 4621 patients. The prevalence of thoracic lymphadenopathy varied between 1 % and 73.4 %. The pooled prevalence was 16.7 %, 95 % CI = (15.6 %; 17.8 %). The hospital mortality was higher in patients with thoracic lymphadenopathy (34.7 %) than in patients without (20.0 %). The pooled odds ratio for the influence of thoracic lymphadenopathy on mortality was 2.13 (95 % CI = [1.80–2.52], p < 0.001).
Conclusion The prevalence of thoracic lymphadenopathy in COVID-19 is 16.7 %. The presence of thoracic lymphadenopathy is associated with an approximately twofold increase in the risk for hospital mortality in COVID-19.
Key Points
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The Role of Botulinum Toxin A Neuromodulator in the Management of Synkinesis in Facial Palsy
Authors: Yener Asalet , Acharya Vikas , Andrews Peter , Meller Catherine , Shamil Eamon 
Published: July 2024

AbstractFacial palsy describes the denervation of the facial nerve leading to difficulty in facial animation and expression. Facial synkinesis is the result of complex pathological nerve regeneration following damage to the facial nerve axons. Synkinesis in facial palsy can be managed using facial neuromuscular rehabilitation, botulinum toxin neuromodulators, and surgical treatment options. Botulinum toxin A can be used as an adjunct to other treatment options to manage synkinesis. This article will explore the role of botulinum toxin A in the management of synkinesis in facial palsy including the clinical assessment, injection location (muscles targeted), dosages, treatment interval, and long-term results. It will also include surgical management options.
Access to 1,3- and 1,5-Disubstituted 1,2,4-Triazoles by Condensation of Acyl Hydrazides with Formamidinium Acetate
Authors: Bremerich Maximilian 
Published: July 2024

AbstractA simple redox-neutral method for the regioselective preparation of 1,3- and 1,5-disubstituted 1,2,4-triazoles from the corresponding unactivated acyl hydrazides and the inexpensive, non-toxic, and shelf-stable formamidinium acetate was developed. The addition of zinc salts proved to be pivotal to ensure full regioselectivity for the 1,3-disubstitution pattern, while 1,5-disubstituted 1,2,4-triazoles could be accessed without. A variety of sensitive functional groups were tolerated, and [1,2,4]triazolo[4,3-a]pyridines were obtained from the corresponding 2-hydrazopyridines without Dimroth rearrangement.
The reality of epilepsy in primary care in Rio de Janeiro: the importance of educational projects for better patient care
Authors: Lessa Vanessa Cristina Colares , Martins Marília Bezerra Magalhães , Vidal Alexandra Seide Cardoso , Araujo Leonardo Alves , D'Andrea Meira Isabella 
Published: July 2024

Abstract
Background The Basic Health Unit (Unidade Básica de Saúde – UBS, in Portuguese) is the first point of contact in the public healthcare system for people with epilepsy. Primary care professionals need to appropriately diagnose, treat, and refer, if necessary, to tertiary services.
Objective To evaluate the knowledge of UBS professionals on the management of patients with epilepsy in Rio de Janeiro.
Methods Online questionnaires were performed on the topic of epilepsy before and after exposure to classes taught by epileptologists.
Results A total of 66 doctors participated, 54.5% of whom were residents or trained in family medicine. The majority had from 1 to 3 years of practice. Insecurity prevailed in the management of pregnant women and the elderly. Around 59.1% of the participants referred patients with seizures without examinations. A total of 78% of the participants did not correctly classify seizure types, and 2/3 did not define drug-resistant epilepsy. Induction and broad-spectrum drugs were common. The therapeutic decision depended on availability in the basic health unit (UBS) (81.8%), dosage (60.6%), side effects (34.8%), and age (36.4%). Comorbidities and sex influenced 1/4 of the sample. For 23% of the participants, the type of crisis did not affect the choice. Regarding typical non-pharmacological options, 75% of the participants were aware of cannabidiol, 40.9% of surgery, 22.7% of ketogenic diet, and 22.8% of deep brain stimulation/vagus nerve stimulation (DBS/VNS). A total of 90.2% indicated the need for training.
Conclusion There are deficits in the knowledge of UBS professionals in the management of epilepsy. Specialized training is imperative to optimize the care offered within SUS.
Lasting Effects of Surgically Used Topical Vasodilators on DIEP Artery Vascular Function
Authors: Kofoed Jason S. , Tuncer Fatma B. , Kwok Alvin C. , Agarwal Jayant P. , Ruple Bradley A. , Borrelli Marta , Symons J. David , Richardson Russell S. , Broxterman Ryan M. 
Published: July 2024

Abstract
Background Surgeons routinely apply papaverine, lidocaine, or verapamil to produce acute vasodilation and prevent vasospasms during microvascular surgeries. There is evidence that topical vasodilators may induce postoperative endothelial and smooth muscle dysfunction, which would present after the acute vasodilatory effects of the topical drugs wear off. Therefore, the purpose of the current study was to evaluate the lasting effects of papaverine, lidocaine, and verapamil on human deep inferior epigastric perforator artery vasodilatory function after the acute effects of the topical drugs had worn off.
Methods Deep inferior epigastric arterial samples were obtained from 12 patients during surgery. Each artery was dissected into four rings which where incubated for 1 minute in either physiological saline solution (control), papaverine (30 mg/mL), lidocaine (20 mg/mL), or verapamil (2.5 mg/mL), followed by a 2-hour washout. Endothelial-dependent and -independent vasorelaxation were then assessed by the isometric tension responses to acetylcholine or sodium nitroprusside, respectively.
Results Peak acetylcholine-evoked vasorelaxation (mean ± standard deviation) was not different between control (62 ± 23%) and lidocaine (57 ± 18%, p = 0.881), but was reduced (all p < 0.002) in papaverine (22 ± 27%) and verapamil (22 ± 20%). Peak sodium nitroprusside-evoked vasorelaxation was not different (all p > 0.692) among control (132 ± 35%), lidocaine (121 ± 22%), and verapamil (127 ± 22%), but was less in papaverine (104 ± 41%; p = 0.045) than control.
Conclusion Surgically used doses of papaverine and verapamil, but not lidocaine, have lasting negative effects on arterial vasodilatory function despite the acute effects of the drugs having worn off. These findings, in conjunction with the spasmolytic properties of each drug, may help guide the selection of an optimal topical vasodilator for use during microvascular surgeries.
Microvascular Free-Flap Head and Neck Reconstruction: The Utility of the Modified Frailty Five-Item Index
Authors: Othman Sammy , Robinson Emma , Kamdar Dev , Pereira Lucio , Miles Brett , Kasabian Armen , Ricci Joseph A. , Knobel Denis 
Published: July 2024

Abstract
Background Microvascular free tissue transfer is a common tool for the reconstruction of oncologic head and neck defects. Adequate preoperative assessment can aid in appropriate risk stratification and peri-operative optimization. The modified five-item frailty index (mFI-5) is a validated risk-assessment scale; however, its utility in head and neck free-flap reconstruction is unknown when compared with other common risk factors.
Methods A retrospective, single-institution chart review (2017–2020) was performed. Patient demographics, defect and repair characteristics, pre- and peri-operative factors, and flap outcomes were recorded. A high mFI-5 score was defined as greater than 2. The total score, as well as other patient factors, was correlated to postoperative flap complications.
Results A total of 214 patients were deemed appropriate for conclusion. The mean age was 63.9 ± 12.8 years. There were an even number of males (52.8%) and females (47.2%). A fifth of subjects (20.8%) underwent preoperative radiotherapy. There were 21 cases (9.8%) of complete flap loss. A total of 34 patients (29.4%) experienced any postoperative complication related to flap outcomes. An elevated mFI-5 was significantly associated with a higher overall rate of postoperative complications (39.7 vs. 29.4%, p < 0.019) and total flap loss (16.7% vs. 6.6%, p < 0.033). Preoperative radiation was found to be associated with an increased complication rate (p < 0.003).
Conclusion The mFI-5 score may be a potentially significant tool in the risk stratification of patients undergoing head and neck free-flap reconstruction as opposed to commonly utilized risk factors. Preoperative radiotherapy is significantly associated with postoperative complications. Appropriate preoperative assessment may help tailor patient care preoperatively.
HoloDIEP—Faster and More Accurate Intraoperative DIEA Perforator Mapping Using a Novel Mixed Reality Tool
Authors: Necker Fabian N. , Cholok David J. , Fischer Marc J. , Shaheen Mohammed S. , Gifford Kyle , Januszyk Michael , Leuze Christoph W. , Scholz Michael , Daniel Bruce L. , Momeni Arash 
Published: July 2024

Abstract
Background Microsurgical breast reconstruction using abdominal tissue is a complex procedure, in part, due to variable vascular/perforator anatomy. Preoperative computed tomography angiography (CTA) has mitigated this challenge to some degree; yet it continues to pose certain challenges. The ability to map perforators with Mixed Reality has been demonstrated in case studies, but its accuracy has not been studied intraoperatively. Here, we compare the accuracy of “HoloDIEP” in identifying perforator location (vs. Doppler ultrasound) by using holographic 3D models derived from preoperative CTA.
Methods Using a custom application on HoloLens, the deep inferior epigastric artery vascular tree was traced in 15 patients who underwent microsurgical breast reconstruction. Perforator markings were compared against the 3D model in a coordinate system centered on the umbilicus. Holographic- and Doppler-identified markings were compared using a perspective-corrected photo technique against the 3D model along with measurement of duration of perforator mapping for each technique.
Results Vascular points in HoloDIEP skin markings were −0.97 ± 6.2 mm (perforators: −0.62 ± 6.13 mm) away from 3D-model ground-truth in radial length from the umbilicus at a true distance of 10.81 ± 6.14 mm (perforators: 11.40 ± 6.15 mm). Absolute difference in radial distance was twice as high for Doppler markings compared with Holo-markings (9.71 ± 6.16 and 4.02 ± 3.20 mm, respectively). Only in half of all cases (7/14), more than 50% of the Doppler-identified points were reasonably close (<30 mm) to 3D-model ground-truth. HoloDIEP was twice as fast as Doppler ultrasound (76.9s vs. 150.4 s per abdomen).
Conclusion HoloDIEP allows for faster and more accurate intraoperative perforator mapping than Doppler ultrasound.
Dynamic Eye Closure Restoration in Facial Palsy with Neurotized Platysma Muscle Graft in Rats
Authors: Voravitvet Tsz Yin , Huang Yenlin , Voravitvet Sawarin , Larsson Juan , Lien Po-Hao , Chuang David Chwei-Chin , Lu Johnny Chuieng-Yi , Chang Tommy Nai-Jen 
Published: July 2024

Abstract
Background One of the most devastating deficits of facial paralysis is eyelid dysfunction, which is controlled by the orbicularis oculi muscle (OOM), as it leads to loss of the protective mechanism of the eye. This study used a rat model to assess the functional outcomes of neurotized platysma muscle grafts (PMGs) for OOM replacement.
Methods Forty male Sprague-Dawley rats with iatrogenic right eyelid dysfunction were divided into five groups: one control group and four groups utilizing PMG with different sources of nerve innervation. Eyelid function recovery was assessed at 2, 4, 6, and 8 weeks. The PMGs were harvested for pathological examination at the end of the study.
Results All rats except those in the control group and one from the group using ipsilateral frontal and upper zygomatic frontal nerve branches directly neurotized to the PMG (nerve-to-muscle) recovered eyelid closure function within 8 weeks of the study period. The mean recovery time was 3.87 ± 1.28 weeks. A total of 87.5% of rats that had the contralateral zygomatic branch as the donor nerve regained the consensual corneal reflex (p-value < 0.001).
Conclusion Replacement of neurotized PMG for OOM function is successful in a rat model. Using the upper zygomatic branch as the donor nerve, it was possible to restore the consensual corneal reflex. This method shows promise for further human studies.