bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and clinical activity of JNJ-78306358, a human leukocyte antigen-G (HLA-G) x CD3 bispecific antibody, for the treatment of advanced stage solid tumors
Authors: Geva Ravit , Vieito Maria , Ramon Jorge , Perets Ruth , Pedregal Manuel , Corral Elena , Doger Bernard , Calvo Emiliano , Bardina Jorge , Garralda Elena , Brown Regina J. , Greger James G. , Wu Shujian , Steinbach Douglas , Yao Tsun-Wen Sheena , Cao Yu , Lauring Josh , Chaudhary Ruchi , Patel Jaymala , Patel Bharvin , Moreno Victor 
Published: August 2024

Abstract
Background
JNJ-78306358 is a bispecific antibody that redirects T cells to kill human leukocyte antigen-G (HLA-G)-expressing tumor cells. This dose escalation study evaluated the safety, pharmacokinetics, pharmacodynamics, and preliminary antitumor activity of JNJ-78306358 in patients with advanced solid tumors.

Methods
Adult patients with metastatic/unresectable solid tumors with high prevalence of HLA-G expression were enrolled. Dose escalation was initiated with once-weekly subcutaneous administration with step-up dosing to mitigate cytokine release syndrome (CRS).

Results
Overall, 39 heavily pretreated patients (colorectal cancer: n = 23, ovarian cancer: n = 10, and renal cell carcinoma: n = 6) were dosed in 7 cohorts. Most patients (94.9%) experienced ≥ 1 treatment-emergent adverse events (TEAEs); 87.2% had ≥ 1 related TEAEs. About half of the patients (48.7%) experienced CRS, which were grade 1/2. Nine patients (23.1%) received tocilizumab for CRS. No grade 3 CRS was observed. Dose-limiting toxicities (DLTs) of increased transaminases, pneumonitis and recurrent CRS requiring a dose reduction were reported in 4 patients, coinciding with CRS. No treatment-related deaths reported. No objective responses were noted, but 2 patients had stable disease > 40 weeks. JNJ-78306358 stimulated peripheral T cell activation and cytokine release. Anti-drug antibodies were observed in 45% of evaluable patients with impact on exposure. Approximately half of archival tumor samples (48%) had expression of HLA-G by immunohistochemistry.

Conclusion
JNJ-78306358 showed pharmacodynamic effects with induction of cytokines and T cell activation. JNJ-78306358 was associated with CRS-related toxicities including increased transaminases and pneumonitis which limited its dose escalation to potentially efficacious levels.
Trial registration number ClinicalTrials.gov (No. NCT04991740).
Rethinking Urban Water Management Through Drivers-Pressures-States-Impacts-Responses Framework Application in Chennai, India
Authors: Rosado Daniel , Fárez-Román Valeria , Müller Felix , Nambi Indumathi , Fohrer Nicola 
Published: August 2024

AbstractCities suffering water scarcity are projected to increase in the following decades. However, the application of standardized indicator frameworks for assessing urban water resource management problems is on an early stage. India is expected to have the highest urban population facing water scarcity in the world by 2050. In this study, the authors assess how the Drivers-Pressures-States-Impacts-Responses framework, a causal framework adopted by the European Environment Agency, can contribute to evaluate water management challenges in cities and apply it to Chennai, India´s fourth-largest urban agglomeration. The framework proved to be a helpful tool for the evaluation of water management challenges in cities by disentangling relationships between environmental indicators and structuring dispersed data that allows a better understanding for policymakers. The main drivers identified in Chennai were population growth and economic development which generated impacts such as loss of aquatic ecosystems, low water table, low water quality, and reduction of biodiversity and human health. As a response, better urban planning, projects for new water infrastructure, and water bodies restoration have been implemented. Nevertheless, Chennai keeps facing difficulties to achieve proper water management. The severe hit of the COVID-19 pandemic on the Indian economy and its future management will be key for achievements related to water management.
The impact of anastomotic leakage characteristics on the occurrence of anastomotic stenosis after colorectal resection, a retrospective cohort study
Authors: Abdelhadi Schaima , Tzatzarakis Emmanouil , Hermann Maike , Orth Vanessa , Vedder Katharina , Briscoe Jannis , Reissfelder Christoph , Șandra-Petrescu Flavius 
Published: August 2024

Abstract
Introduction
Anastomotic stenosis (AS) is a common complication after colorectal resection. However, the predisposing factors for stricture formation are not fully understood. Previous studies have shown anastomotic leakage (AL) to be a risk factor for the occurrence of AS. Therefore, we aim to investigate the impact of anastomotic leakage characteristics on the occurrence of anastomotic stenosis after colorectal resection.

Methods
Consecutive patients with AL following elective, sphincter preserving, colorectal resection, with or without diversion ostomy, between January 2009 and March 2023 were identified from a prospectively collected database. The characteristics of the anastomotic leakage, patient baseline and operative characteristics as well as the postoperative outcomes were analyzed using univariate and multivariate logistic regression to identify factors associated with the occurrence of post-leakage AS.

Results
A total of 129 patients developed AL and met the inclusion criteria. Among these, 28 (21.7%) patients were diagnosed with post-leakage AS. There was a significantly higher frequency of patients with neoadjuvant radiotherapy (18% vs 3%; p = .026) and hand-sewn anastomoses (39% vs 17%; p = .011) within the AS group. Furthermore, the extent of the anastomotic defect was significantly higher in the AS group compared with the non-AS group (50%, IQR 27–71 vs. 20%, IQR 9–40, p = 0.011). Similar findings were observed between the study groups regarding age, sex, BMI, ASA score, medical comorbidities, diagnosis, surgical procedure, surgical approach (open vs. minimally invasive), and anastomotic fashioning (side-to-end vs. end-to-end). On multivariate analysis, the extent of the anastomotic defect (OR 1.01; 95% CI 1.00–1.03; p = 0.034) and hand-sewn anastomoses (OR 2.68; 95% CI 1.01–6.98; p = 0.043) were confirmed as independent risk factors for post-leakage AS. No correlation could be observed between the occurrence of post-leakage AS and the ISREC grading of AL, the anastomotic height or the management of AL. Time to ostomy reversal was significantly longer in the AS group (202d, IQR 169–275 vs. 318d IQR 192–416, p = 0.014).

Conclusion
The extent of the anastomotic defect and hand-sewn anastomoses were confirmed as independent risk factors for the occurrence of post-leakage AS. No correlation could be observed between the ISREC grading of AL, the anastomotic height or AL management, and the occurrence of post-leakage AS.
Outcomes of patients admitted with malignant small bowel obstruction: a subgroup multicentre observational cohort analysis
Authors: Hupfeld N. B. , Burcharth J. , Jensen T. K. , Lolle I. , Nielsen L. B. J. , Tolver M. A. , Skovsen A. P. , Smith H. G. 
Published: August 2024

Abstract
Introduction and purpose of the study
Small bowel obstruction (SBO) accounts for a substantial proportion of emergency surgical admissions. Malignancy is a common cause of obstruction, either due to a primary tumour or intra-abdominal metastases. However, little is known regarding the current treatment or outcomes of patients with malignant SBO. This study aimed to characterise the treatment of malignant SBO and identify areas for potential improvement and compare overall survival of patients with malignant SBO to patients with non-malignant SBO.

Materials and methods
This was a subgroup analysis of a multicentre observational study of patients admitted with SBO. Details regarding these patients’ diagnoses, treatments, and outcomes up to 1-year after admission were recorded. The primary outcome was overall survival in patients with malignant SBO.

Results
A total of 316 patients with small bowel obstruction were included, of whom 33 (10.4%) had malignant SBO. Out of the 33 patients with malignant SBO, 20 patients (60.6%) were treated with palliative intent although only 7 patients were seen by a palliative team during admission. Nutritional assessments were performed on 12 patients, and 11 of these patients received parenteral nutrition. 23 patients underwent surgery, with the most common surgical interventions being loop ileostomies (9 patients) and gastrointestinal bypasses (9 patients). 4 patients underwent right hemicolectomies, with a primary anastomosis formed and 1 patient had a right hemicolectomy with a terminal ileostomy. Median survival was 114 days, and no difference was seen in survival between patients treated with or without palliative intent.

Conclusion
Malignant SBO is associated with significant risks of short-term complications and a poor prognosis. Consideration should be given to the early involvement of senior decision-makers upon patient admission is essential for optimal management and setting expectation for a realistic outcome.
Advancements in triple-negative breast cancer sub-typing, diagnosis and treatment with assistance of artificial intelligence : a focused review
Authors: Batool Zahra , Kamal Mohammad Amjad , Shen Bairong 
Published: August 2024

AbstractTriple negative breast cancer (TNBC) is most aggressive type of breast cancer with multiple invasive sub-types and leading cause of women’s death worldwide. Lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) causes it to spread rapidly making its treatment challenging due to unresponsiveness towards anti-HER and endocrine therapy. Hence, needing advanced therapeutic treatments and strategies in order to get better recovery from TNBC. Artificial intelligence (AI) has been emerged by giving its high inputs in the automated diagnosis as well as treatment of several diseases, particularly TNBC. AI based TNBC molecular sub-typing, diagnosis as well as therapeutic treatment has become successful now days. Therefore, present review has reviewed recent advancements in the role and assistance of AI particularly focusing on molecular sub-typing, diagnosis as well as treatment of TNBC. Meanwhile, advantages, certain limitations and future implications of AI assistance in the TNBC diagnosis and treatment are also discussed in order to fully understand readers regarding this issue.
Graphical Abstract
Balint groups’ possible role in self-care and job satisfaction of general practitioners—A qualitative study
Authors: Schweiger Karina , Hofbaur Benedikt , Rabady Susanne 
Published: August 2024

Summary

Background
Concerns are growing when it comes to the shortage of primary care physicians, therefore it seems necessary to take a closer look at job satisfaction and self-care as one of many influences on career choice. A higher job satisfaction reduces the risk to experience burnout and job-related stress and in addition it will contribute to staying in the profession. The objective of this study is to investigate the impact of regular participation in Balint groups on job satisfaction and self-care among general practitioners.

Methods
Descriptive qualitative study with semi-structured expert interviews of 7 general practitioners. Thematical analysis of data and narrative summary.

Results
A total of 402 coded segments were categorized into 8 main themes and 39 subthemes. Interviewees emphasized changes in self-care and job satisfaction as a result of Balint work and mentioned Balint work as a burnout prophylaxis for themselves. Competences that were learnt or improved through Balint work were described as well as aspects such as feedback and connection with colleagues or professional challenges and difficulties.

Conclusion
The results of the study give rise to the assumption that regular participation in Balint groups might help to improve self-care, resilience, and contribute to job satisfaction. Further research is needed before a general recommendation can be made. Many positive aspects were described by the experts, while no harmful negative influences of Balint work were identified.
On-site extraction of benzophenones from swimming pool water using hybrid tapes based on the integration of hydrophilic-lipophilic balance microparticles and an outer magnetic nanometric domain
Authors: Belhameid Ahmed , Casado-Carmona Francisco Antonio , Megriche Adel , López-Lorente Ángela Inmaculada , Lucena Rafael , Cárdenas Soledad 
Published: August 2024

AbstractAn on-site extraction device is presented consisting of scotch tape modified with concentric domains of micrometric hydrophilic-lipophilic balance (HLB) particles surrounded by a ring of nanometric magnetic ones. On the one hand, HLB microparticles are readily available at the surface of the tape, exposed to interact with the target analytes, being responsible for the extraction capacity of the sorptive phase. On the other hand, the presence of magnetic nanoparticles enables the attachment of the modified tape onto a metallic screw via a magnet, which is then coupled to a wireless drill, enabling the stirring of the microextraction device. Both are simply fixed to the cost-effective, flexible, and versatile support, i.e., scotch tape, owing to their adhesive properties. The microextraction device has been applied to the determination of six benzophenones in swimming pool water samples. The variables that may affect the extraction process have been evaluated. Under the optimum conditions and using liquid chromatography-tandem mass spectrometry as the instrumental technique, the method provided a limit of detection of 0.03 µg L−1. The intra-day precision, evaluated at three different concentration levels and expressed as relative standard deviation, was lower than 10%, which also comprises the variability within single-use sorptive tapes. The accuracy, calculated with spiked samples and expressed as relative recovery, ranged from 71 to 138%. The method was applied to the analysis of swimming pool water, revealing the presence of such compounds.
Graphical Abstract
Elektronische Patientenakte und Freigabe von Gesundheitsdaten
Authors: Haug Sonja , Altenbuchner Amelie , Weber Karsten 
Published: August 2024

Zusammenfassung
Hintergrund
In Deutschland wird die elektronische Patientenakte (ePA) eingeführt.

Fragestellung
Untersucht werden Nutzungsbereitschaft der ePA, Einstellung zu Gesundheitsdaten und Datenübermittlung bei Personen mit und ohne Kinder.

Methoden
Telefonbefragung bei einer Zufallsstichprobe der Bevölkerung in Deutschland (2022, n = 1308).

Ergebnisse
Die ePA ist bei Haushalten mit Kindern mehrheitlich unbekannt. Ihre Nutzungsbereitschaft der ePA und die Zustimmung zur Speicherung von Gesundheitsdaten ist geringer, aber sie sind häufiger als Haushalte ohne Kinder bereit zur Freigabe ihrer Gesundheitsdaten für die Forschung.

Schlussfolgerung
Es besteht Aufklärungsbedarf über die Speicherung von Gesundheitsdaten. Gewünscht wird zunehmend eine digitale Arzt-Patienten-Kommunikation.
Electrochemical goniometry: keystone reactivity at the three-phase boundary
Authors: Varley Thomas S. , Lawrence Nathan S. , Wadhawan Jay D. 
Published: August 2024

AbstractContact angles of liquid, spherical cap droplets immobilised on an electrode surface and bathed by a fluid are important, quantifiable measures of the liquid/fluid interfacial tension. Optical goniometry, even if computer assisted, suffers when the contact angle is 10° or less. In this work, an alternative method of measurement is considered: electrochemical techniques (voltammetry and chronoamperometry), which rely on the transport of material from within the droplet to the conductive surface. As a result of the reactions that take place at the triple phase boundary, these are demonstrated to provide information on the size and the shape of the droplet, including its contact angle, for the cases when the droplets have a redox analyte and either have a supporting electrolyte, or not. The voltammetric behaviour is seen to change from exhaustive, thin film characteristics, to quasi-steady-state signals as the droplet becomes bigger, or the scan rate becomes larger, or diffusion of the redox material inside the droplet becomes slower. One of the surprising outcomes is that there is a zone of planar diffusion only in the case of the supported droplets, with both the droplet size and its contact angle determining whether this is seen at conventional combinations of scan rates and diffusion coefficients. Experimental data are provided which emphasize key features pertaining to the nature of the redox system and illustrate the facile nature of the contact angle estimation process, albeit to within 10% uncertainty.
The effect of imbrication on the porosity value of uniform gravel bed
Authors: Xu Wenjia , Brüll Catrina , Schüttrumpf Holger , Frings Roy M. , Vollmer Stefan 
Published: August 2024

AbstractExisting empirical relations used to predict the porosity of gravel beds are mainly derived from laboratory-generated sediment beds with random grain packing. However, such relations could not adequately describe beds with non-random grain arrangements that occur widely in fluvial deposits. In this work, the effect of grain imbrication on gravel-bed porosity has been quantified using beds with variable strengths of imbrication generated by flume experiments. Mono-sized ellipsoids with specific shapes were used in experiments to remove particle size and sorting effects on porosity. Random bed packings were generated by settling of ellipsoids in still water whilst imbricated beds generated under flowing water. Beds were frozen using liquid nitrogen before extraction. A new relatively simple and time-saving workflow was developed to measure the orientation of particles and quantify the degree of grain imbrication in frozen beds from X-ray Computed Tomography images. Beds with the strongest grain fabric display a ca. 0.03 absolute reduction of porosity value on average (8–10% relative reduction) compared to that of random packing for undisturbed beds. Further, results were obtained for beds deposited under still-water conditions subject to disturbance by shaking, to mimic the potential effect of vibrations from currents, waves or other sources in the environment. A reduction in bed porosity of ca. 0.014–0.018 (ca. 5% relative reduction) is observed between beds with the strongest grain fabric and those with random packing that had undergone shaking after deposition. Hence, a significant proportion (> 50%) of the porosity loss observed for imbricated beds may be attributable to tighter packing due to turbulence-related vibrations from the flow. The small decrease in porosity value despite the formation of strong imbrication is considered to be due to the limited improvement in grain organization, as the results show that the flat shape of the ellipsoids and the uniformity of their size promote the formation of a stacking structure under gravity, leading to a similarly highly ordered grain organization in random packings compared to the imbricated packings.
Graphical abstract
Lack of association between TRPV1 gene polymorphisms and risk of migraine chronification: a case-control study and meta-analysis
Authors: Giacon Martina , Cargnin Sarah , Allena Marta , Greco Rosaria , Zanaboni Anna Maria , Facchetti Sara , De Icco Roberto , Sances Grazia , Ghiotto Natascia , Guaschino Elena , Martinelli Daniele , Tassorelli Cristina , Terrazzino Salvatore 
Published: August 2024

Abstract
Objective
To confirm a previously reported association of TRPV1 rs8065080 with the risk of transformation from episodic (EM) to chronic migraine (CM) and to extend knowledge about the role of other TRPV1 single nucleotide polymorphisms (SNPs), we first investigated the impact of three TRPV1 SNPs (rs8065080, rs222747 and rs222749) on the risk of migraine chronification in a case-control study. A systematic review and meta-analysis were then conducted to summarize the accumulated findings.

Methods
Genotyping of the selected TRPV1 SNPs was performed using TaqMan real-time PCR in 167 EM and 182 CM participants. Crude and adjusted odds ratios with associated 95% confidence intervals were calculated in the log-additive, dominant, and recessive genetic models. A comprehensive literature search was performed in PubMed, Web of Knowledge, Cochrane Library, and OpenGrey until February 2024.

Results
In our case-control study, no association was found between TRPV1 SNPs and the risk of migraine chronification, both in the unadjusted logistic regression models and after adjustment for confounding clinical variables. The results of the meta-analysis with a total of 241 participants with EM and 223 with CM confirmed no association between TRPV1 SNPs and the risk of migraine chronification in any of the genetic models tested.

Conclusion
The results of the present case-control study and meta-analysis exclude a major role of TRPV1 rs8065080, rs222747, and rs222749 as risk factors for migraine chronification. However, further research is needed to investigate the gene-gene and gene-environment interactions of TRPV1 SNPs on the risk of transformation from episodic to chronic migraine.
Assessment of hepatic transporter function in rats using dynamic gadoxetate-enhanced MRI: a reproducibility study
Authors: Gunwhy Ebony R. , Hines Catherine D. G. , Green Claudia , Laitinen Iina , Tadimalla Sirisha , Hockings Paul D. , Schütz Gunnar , Kenna J. Gerry , Sourbron Steven , Waterton John C. 
Published: August 2024

Abstract
Objective
Previous studies have revealed a substantial between-centre variability in DCE-MRI biomarkers of hepatocellular function in rats. This study aims to identify the main sources of variability by comparing data measured at different centres and field strengths, at different days in the same subjects, and over the course of several months in the same centre.

Materials and methods
13 substudies were conducted across three facilities on two 4.7 T and two 7 T scanners using a 3D spoiled gradient echo acquisition. All substudies included 3–6 male Wistar-Han rats each, either scanned once with vehicle (n = 76) or twice with either vehicle (n = 19) or 10 mg/kg of rifampicin (n = 13) at follow-up. Absolute values, between-centre reproducibility, within-subject repeatability, detection limits, and effect sizes were derived for hepatocellular uptake rate (Ktrans) and biliary excretion rate (kbh). Sources of variability were identified using analysis of variance and stratification by centre, field strength, and time period.

Results
Data showed significant differences between substudies of 31% for Ktrans (p = 0.013) and 43% for kbh (p < 0.001). Within-subject differences were substantially smaller for kbh (8%) but less so for Ktrans (25%). Rifampicin-induced inhibition was safely above the detection limits, with an effect size of 75 ± 3% in Ktrans and 67 ± 8% in kbh. Most of the variability in individual data was accounted for by between-subject (Ktrans = 23.5%; kbh = 42.5%) and between-centre (Ktrans = 44.9%; kbh = 50.9%) variability, substantially more than the between-day variation (Ktrans = 0.1%; kbh = 5.6%). Significant differences in kbh were found between field strengths at the same centre, between centres at the same field strength, and between repeat experiments over 2 months apart in the same centre.

Discussion
Between-centre bias caused by factors such as hardware differences, subject preparations, and operator dependence is the main source of variability in DCE-MRI of liver function in rats, closely followed by biological between-subject differences. Future method development should focus on reducing these sources of error to minimise the sample sizes needed to detect more subtle levels of inhibition.