bluuebunny/crossref_metadata_2025_split huggingface dataset:
Driving and legal status of Spanish opioid-dependent patients
Authors: Roncero Carlos , Álvarez F Javier , Barral Carmen , Gómez-Baeza Susana , Gonzalvo Begoña , Rodríguez-Cintas Laia , Brugal M Teresa , Jacas Carlos , Romaguera Anna , Casas Miguel 
Published: June 2013

Abstract

Background
Opioid dependent patients have legal problems, driving violations and accidents more frequently than the general population. We have hypothesized that those patients currently driving may have better legal outcomes than those who do not possess a valid driving license. With this aim we have analyzed the information gathered in the PROTEUS study regarding the legal and driving statuses and assessed the possible association between them. The PROTEUS study was an observational, cross-sectional, descriptive, multicenter nationwide representative study, conducted in Spanish healthcare centers for opioid dependent patients.

Findings
The driving and legal statuses of a population of opioid dependent patients ≥18 years and enrolled in Opioid Agonist Therapy treatment centers in Spain, were assessed using a short specific questionnaire and the EuropASI questionnaire to highlight distinct individual clinical needs. 621 patients were evaluable (84% men, 24.5% active workers). 321 patients (52%) drove on a regular basis. Nineteen percent of patients had some problem with the criminal justice system. There was a significant difference (p = 0.0433) in status, according to the criminal justice system, between patients who drove on a regular basis and those who did not, with a higher percentage of patients with non-pending charges among usual drivers.

Conclusions
Regular drivers showed fewer legal problems than non-regular drivers, with the exception of those related to driving (driving violations and drunk driving). Driving is a good prognostic factor for the social integration of the patients and policies should be implemented to enable these patients to drive safely under medical authorization. The legal description will be useful to assess treatment efficacy.
A quantitative reference transcriptome for Nematostella vectensis earlyembryonic development: a pipeline for de novo assembly in emergingmodel systems
Authors: Tulin Sarah , Aguiar Derek , Istrail Sorin , Smith Joel 
Published: June 2013

Abstract

Background
The de novo assembly of transcriptomes from short shotgun sequencesraises challenges due to random and non-random sequencing biases andinherent transcript complexity. We sought to define a pipeline for denovo transcriptome assembly to aid researchers working withemerging model systems where well annotated genome assemblies are notavailable as a reference. To detail this experimental and computationalmethod, we used early embryos of the sea anemone, Nematostellavectensis, an emerging model system for studies of animal body planevolution. We performed RNA-seq on embryos up to 24 h of developmentusing Illumina HiSeq technology and evaluated independent de novoassembly methods. The resulting reads were assembled using either theTrinity assembler on all quality controlled reads or both the Velvet andOases assemblers on reads passing a stringent digital normalization filter.A control set of mRNA standards from the National Institute of Standards andTechnology (NIST) was included in our experimental pipeline to invest ourtranscriptome with quantitative information on absolute transcript levelsand to provide additional quality control.

Results
We generated >200 million paired-end reads from directional cDNA librariesrepresenting well over 20 Gb of sequence. The Trinity assembler pipeline,including preliminary quality control steps, resulted in more than 86% ofreads aligning with the reference transcriptome thus generated.Nevertheless, digital normalization combined with assembly by Velvet andOases required far less computing power and decreased processing time whilestill mapping 82% of reads. We have made the raw sequencing reads andassembled transcriptome publically available.

Conclusions

Nematostella vectensis was chosen for its strategic position in thetree of life for studies into the origins of the animal body plan, however,the challenge of reference-free transcriptome assembly is relevant to allsystems for which well annotated gene models and independently verifiedgenome assembly may not be available. To navigate this new territory, wehave constructed a pipeline for library preparation and computationalanalysis for de novo transcriptome assembly. The gene modelsdefined by this reference transcriptome define the set of genes transcribedin early Nematostella development and will provide a valuabledataset for further gene regulatory network investigations.
Single-molecule photobleaching reveals increased MET receptor dimerization upon ligand binding in intact cells
Authors: Dietz Marina S , Haße Daniel , Ferraris Davide M , Göhler Antonia , Niemann Hartmut H , Heilemann Mike 
Published: June 2013

Abstract

Background
The human receptor tyrosine kinase MET and its ligand hepatocyte growth factor/scatter factor are essential during embryonic development and play an important role during cancer metastasis and tissue regeneration. In addition, it was found that MET is also relevant for infectious diseases and is the target of different bacteria, amongst them Listeria monocytogenes that induces bacterial uptake through the surface protein internalin B. Binding of ligand to the MET receptor is proposed to lead to receptor dimerization. However, it is also discussed whether preformed MET dimers exist on the cell membrane.

Results
To address these issues we used single-molecule fluorescence microscopy techniques. Our photobleaching experiments show that MET exists in dimers on the membrane of cells in the absence of ligand and that the proportion of MET dimers increases significantly upon ligand binding.

Conclusions
Our results indicate that partially preformed MET dimers may play a role in ligand binding or MET signaling. The addition of the bacterial ligand internalin B leads to an increase of MET dimers which is in agreement with the model of ligand-induced dimerization of receptor tyrosine kinases.
The Simcyp Population Based Simulator: Architecture, Implementation, and Quality Assurance
Authors: Jamei Masoud , Marciniak Steve , Edwards Duncan , Wragg Kris , Feng Kairui , Barnett Adrian , Rostami-Hodjegan Amin 
Published: June 2013

AbstractDeveloping a user-friendly platform that can handle a vast number of complex physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) models both for conventional small molecules and larger biologic drugs is a substantial challenge. Over the last decade the Simcyp Population Based Simulator has gained popularity in major pharmaceutical companies (70% of top 40 - in term of R&D spending). Under the Simcyp Consortium guidance, it has evolved from a simple drug-drug interaction tool to a sophisticated and comprehensive Model Based Drug Development (MBDD) platform that covers a broad range of applications spanning from early drug discovery to late drug development. This article provides an update on the latest architectural and implementation developments within the Simulator. Interconnection between peripheral modules, the dynamic model building process and compound and population data handling are all described. The Simcyp Data Management (SDM) system, which contains the system and drug databases, can help with implementing quality standards by seamless integration and tracking of any changes. This also helps with internal approval procedures, validation and auto-testing of the new implemented models and algorithms, an area of high interest to regulatory bodies.
Simultaneous joint inversion of amplitude-versus-offset and controlled-source electromagnetic data by implicit representation of common parameter structure
Authors: Lien Martha 
Published: June 2013

I evaluated a simultaneous joint inversion of seismic amplitude-versus-offset (AVO) and controlled-source electromagnetic (CSEM) data for fluid-flow monitoring. A new approach for structure-coupled joint inversion was presented, in which the coupling of the two data types was obtained by allowing for the direct identification of parameter structure that is shared by the different geophysical model parameters. The main idea was to use a composite parameter representation, which enables inversion with respect to the parameter magnitude and parameter structure. In the current application, parameter structure refers to transitions between dominating property values and is represented by the position and shape of the flooding front. Hence, with this approach, the position and shape of the flooding front are inverted for directly, and the coupling between the different data sets is obtained without the inclusion of an additional penalizing term in the objective function. Regularization of the inverse problem is obtained by using a flexible parameterization grid adapted to the resolution power of the available data. This approach is especially suited for problems in which the prior information is limited or highly uncertain. The solution approach is illustrated for two types of coupling: (1) identification of fluid saturation using rock-physics modeling and (2) for structure-coupled joint inversion with respect to P-wave velocity and electric conductivity. Through various synthetic examples in 2D, the proposed approach showed its efficiency for identifying the main features of the fluid distribution within the reservoir. Simultaneously inverting AVO and CSEM data was further seen to give results that were more robust with respect to certain random and more systematic (modeling) errors compared with inverting the data sets separately.
Multimorbidity and mental health: can psychiatry rise to the challenge?
Authors: Langan Julie , Mercer Stewart W. , Smith Daniel J. 
Published: June 2013

SummaryMultimorbidity - the co-occurrence of two or more long-term conditions in an individual - is highly relevant to psychiatry. Changes to training and a more integrated model of psychiatric and physical healthcare are needed in the future if we are to improve the long-term health of our patients.
Complex needs survey: informing the development of a community recovery and rehabilitation team
Authors: Bekas Stavros 
Published: June 2013

Aims and methodTo inform the development of a new, recovery-oriented rehabilitation service, identify local needs and create a pathway for appropriate referrals, accelerating the build up of case-load. We surveyed 1353 secondary service users using a purpose-made needs assessment and case identification questionnaire, completed by nominated care coordinators.ResultsSignificant unmet need for rehabilitation and recovery-oriented interventions was found. The results were used to invite referrals, create a case-load of 150 and allocate the appropriate resources for the new team.Clinical implicationsThe results highlight the untapped recovery potential among users of mainstream secondary mental health services and support investment in rehabilitation at a time of resource restriction. This work also supports a similar, evidence-based approach to targeting appropriate referrals during the development and the early stages of rehabilitation services.
5,10-Dihydrobenzo[a]indolo[2,3-c]carbazole: A Highly Fluorescent Disk-shaped Electron Donor Exhibiting Dual UV–vis–NIR and Fluorescence Spectral Changes upon Electrolysis
Authors: Suzuki Takanori , Tokimizu Yusuke , Sakano Yuto , Katoono Ryo , Fujiwara Kenshu , Naoe Saori , Fujii Nobutaka , Ohno Hiroaki 
Published: June 2013

Abstract
Through gold(I)-catalyzed cascade cyclization as a key step, the title electron donor was prepared, which adopts a planar geometry, as confirmed by an X-ray analysis. Due to 1,4-phenylenediamine moiety incorporated in the framework, it undergoes reversible one-electron oxidation. Upon electrolysis, it exhibited an electrochromic response in the UV–vis–NIR region, which was accompanied by a drastic change in the fluorescence spectrum since only the neutral donor is highly fluorescent.
Reason to Care: The Object and Structure of Self-Knowledge in the Alcibiades I
Authors: Remes Pauliina 
Published: June 2013

Abstract In Alcibiades 1, the object of self-knowledge is approached as a special case because of its interrelations within the polis. But can such a Platonic principle as the priority of definition - knowing what a thing is before one can say anything else that is auhoritative about it - be applied to the object of self-knowledge? The dialogue strives to individuate one aspect of human nature as focal. This is not a divinity outside human agency, but the soul under that aspect that makes it the agent of purposeful action and subject of her own talk and reasoning, worthy of our care.
Effect of Thermal Shock on Grindability of Zircon for Preparation of Zircon Flour
Authors: Routray Sunita , Bhima Raog R. 
Published: June 2013

AbstractThis paper deals with the effect of thermal shock treatment on grindability and grinding characteristics of zircon minerals and the overall energy saving achieved. This attempt is made due to a fine dry grinding of zircon minerals to produce zircon flour is an energy intensive operation. The effect of grinding time on grinding of zircon minerals in a continuously agitated rod mill indicate that the time required is 170 minutes for obtaining 75% of particles passing 45 µm size for natural zircon mineral whereas for thermally treated zircon it is only 100 minutes to achieve the same. Hence, 70 minutes of grinding time is saved. The work index test results show that 13.3% of the total energy can be saved when a sample is preheated to 850 °C and subjected to thermal shock treatment. The effect is due to the development of numerous micro-cracks and fractures in samples subjected to thermal shock.
Wie aus Gedanken Dinge werden. Eine Philosophie der Artefakte
Authors: Reicher Maria E. 
Published: June 2013

Abstract
The aim of this paper is an ontological clarification of the concept of artefact. The following questions are addressed: 1. Do artefacts constitute an ontological category of objects in its own right, and if so, how could this category be characterized? 2. How do artefacts come into existence? 3. What kind of artefacts are there, and in which relations do they stand to each other? It is argued that artefacts are characterized essentially through their genesis and that they owe their existence to mental acts of a particular kind, which I call “acts of creation”. It is maintained that there are not only concrete, material artefacts, but also abstract artefacts, that is, artefacts that cannot be perceived through the senses and are not located in space. Furthermore, it shall be claimed that in a sense those abstract artefacts are even primary to the concrete, material artefacts.
Artefakte
Authors: van Inwagen Peter 
Published: June 2013

Abstract
In this section (i. e. section 13) of his monograph Material Beings, first published in 1990, the author discusses certain sentences – sentences such as “This house has stood here for three hundred years” – that are usually discussed in connection with “the problem of identity through time”. It is argued that these sentences cannot have any very intimate connection with that problem (whatever exactly that problem may be), for there are – as the author suggests by proposing an answer to the so-called Special Composition Question – no such things as houses or other artefacts, and thus there is no problem about their persistence through time.
Warum sich Artefakte ihrer Marginalisierung widersetzen
Authors: Jansen Ludger 
Published: June 2013

Abstract
It is widespread practice to define artefacts as entities that owe their existence to plan-based acts of production that aim at a certain use of the produced thing. According to this definition, artefacts are essentially intention-dependent. For this reason, artefacts are threatened by marginalisation within standard naturalised ontologies. I discuss three families of marginalisation strategies: elimination, reduction and supervenience. I argue that all of these strategies fail, as they lead to false implications, with the possible exception of four-dimensional supervenience, which might well be true, but remains completely uninformative in respect to artefacts. The crucial issue in this regard is what Peter van Inwagen calls the Duplication Principle which is undermined by thought experiments involving chance entities or duplication. Hence, materialistic ontologies are not, as Peter van Inwagen wants us to believe, a Copernican revolution in ontology; they are simply not adequate for the domain of artefacts.
Walter Benjamin als Gemeinplatz. Auswege aus der Kristallisation der Benjamin-Rezeption von Lateinamerika aus
Authors: Buchenhorst Ralph 
Published: June 2013

Abstract
The study at hand critically approaches tendencies of routine and sluggishness in the recent reception of Walter Benjamin’s writings, highlighting and explaining apologetic interpretations in studies which limit themselves to explain the internal logic of Benjamin’s concepts. To that end, it first casts a glance at the debate on how to faithfully translate these concepts. In a second step, it scrutinizes contributors to subaltern studies who use elements of Benjamin’s “pre-history of modernity” in their attempt to uncover historical differences in the process of globalization. To examine their strategies, the present article draws on Latin American perspectives on Benjamin and their attempts to globalize and de-colonize his work.
Inequality, Well-Being and Happiness in Historical Perspective
Authors: Hesse Jan-Otmar , Spoerer Mark 
Published: June 2013

Abstract
Happiness research is a comparably new field of economics. Until Richard Easterlin’s seminal contribution published in 1974, most economists believed there to be a clear and positive correlation between the material standard of living and subjective well-being (or happiness). Economic happiness research has found that, although income matters, inequality, other economic and non-economic factors also play an important role in subjective well-being. Although economic happiness research usually requires longitudinal data, there has so far been no cooperation with economic history.
We argue that contact between these fields might be mutually beneficial to both sides. On the one hand, economic historians are experts on historical datasets and qualitative sources and can assist economists in their quest for information prior to the 1980s. On the other hand, the results of happiness research are valuable for analyzing problems in (economic) history for which traditional economic theory has proved to be insufficient.
Crystal structure of bis(4,5-dihydro-4,4,5,5-tetramethyl-2-(2'-pyridyl- κN)-imidazol-1-oxyl-3-oxide-κO-tris(nitrato-k2O,O')europium(III), C24H32EuN9O13
Authors: Li Dong-Jiao 
Published: June 2013

Abstract C24H32EuN9O13, monoclinic, P21/n (no. 14), a = 12.337(4) Å, b = 11.093(4) Å, c = 23.317(7) Å, β = 98.331(5)°, V = 3157.4 Å3, Z = 4, Rgt(F) = 0.0431, wRref(F2) = 0.1104, T = 293 K.
Crystal structure of 4,4'-(propane-1,3-diyl)bis(pyridin-1-ium)[4-(3,5- dicarboxyphenoxy)-3-nitrobenzoate], (C13H14N2)(C15H9NO9)2, C43H32N4O18
Authors: Liu Yuan-Ying , Guo Jin-Fu , Li Hui-Yun , Zhao Guo-Yan 
Published: June 2013

Abstract C43H32N4O18, monoclinic, C2/c (o. 15), a = 22.409(3) Å, b = 8.280(1) Å, c = 22.146(3) Å, β = 105.242(1)°, V = 3964.7 Å3, Z = 4, Rgt(F) = 0.0482, wRref(F2) = 0.1411, T = 296 K.
Crystal structure of 2,6-dimethoxy-4-((4-(N-(6-methoxypyrimidin-4-yl)- sulfamoyl)phenyl)carbamoyl)phenyl acetate, C22H22N4O8S
Authors: Pan Wei-Gao , Miao Jian-Hua , Xiong Jun , Luo Peng , Lin Cui-Wu 
Published: June 2013

Abstract C22H22N4O8S, triclinic, P1¯ (no. 2), a = 8.730(1) Å, b = 9.730(1) Å, c = 14.220(2) Å, α = 97.970(2)°, β = 92.606(2)°, γ = 100.195(2)°, V = 1174.3 Å3, Z = 2, Rgt(F) = 0.0477, wRref(F2) = 0.1357, T = 296 K.
Crystal structure of trans-diiodidobis(4-phenylpyridine-κN)platinum(II), C22H18I2N2Pt
Authors: Ha Kwang 
Published: June 2013

Abstract C22H18I2N2Pt, monoclinic, P21/c (no. 14), a = 9.072(2) Å, b = 9.158(2) Å, c = 13.169(2) Å, β = 107.281(3)°, V = 1044.8 Å3, Z = 2, Rgt(F) = 0.0319, wRref(F2) = 0.0727, T = 200 K.
Analytical tools for speciation in the field of toxicology
Authors: Bresson Carole , Chartier F. , Ansoborlo Eric , Ortega R. 
Published: June 2013

Abstract
The knowledge of the speciation of elements at trace and ultra-trace level, in biological and environmental media is essential to acquire a better understanding of the mechanisms of toxicity, transport and accumulation in which they are involved. Determining the speciation of an element in a given medium is challenging and requires the knowledge of different methodological approaches: the calculation approach and the experimental approach through the use of dedicated analytical and spectroscopic tools. In this framework, this mini-review reports the approaches to investigate the speciation of elements in biological and environmental media as well as the experimental techniques of speciation analysis, illustrated by recent examples. The main analytical and spectroscopic techniques to obtain structural, molecular, elemental and isotopic information are described. A brief overview of separation techniques coupled with spectrometric techniques is given. Imaging and micro-localisation techniques, which aim at determining the in situ spatial distribution of elements and molecules in various solid samples, are also presented. The last part deals with the development of micro-analytical systems, since they open crucial perspectives to speciation analysis for low sample amounts and analysis on field.
Solution thermodynamic evaluation of hydroxypyridinonate chelators 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO) for UO2(VI) and Th(IV) decorporation
Authors: Sturzbecher-Hoehne M. , Deblonde G. J.-P. , Abergel R. J. 
Published: June 2013

Abstract
Solution thermodynamic studies were performed to characterize the coordination of U(VI) and Th(IV) by the multidentate hydroxypyridinonate chelating agents 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO). Species distribution and conditional stability pM profiles were calculated based on the determined formation constants, showing that both ligands form extremely stable uranyl and thorium complexes in solution. At physiological pH, the formation of 1:1 ligand:uranyl complexes is favored for both ligands, while a 2:1 ligand:thorium complex is predominant with the tetradentate 5-LIO(Me-3,2-HOPO). Comparisons with functionally similar bidentate ligands as well as with the common actinide chelator diethylenetriamine pentaacetic acid emphasized the superior affinity for U(VI) and Th(IV) of both experimental compounds over a wide pH range. These analytical results corroborate the in vivo chelation efficacy of 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO) and validate their selection for further development as therapeutic actinide decorporation agents.