bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of dienogest treatment on uterine fibroid volume in patients with endometriosis or adenomyosis complicated by uterine fibroids
Authors: Zhang De-Yu , Huang Yan , Peng Chao , Zhou Ying-Fang 
Published: June 2024

BACKGROUND
Currently, the use of dienogest in clinical practice has increased significantly, and many studies have focused on its effectiveness and safety in the treatment of endometriosis and adenomyosis; however, the effects of treatment with dienogest on uterine fibroid size in patients with endometriosis or adenomyosis have not been investigated.
AIM
To explore changes in fibroid size in patients with concomitant uterine fibroids undergoing dienogest treatment for endometriosis or adenomyosis and to evaluate the effectiveness and safety of the drug.
METHODS
The clinical data of patients with uterine fibroids treated with dienogest for endometriosis or adenomyosis at Peking University First Hospital from January 2021 to January 2023 were retrospectively analyzed.
RESULTS
The maximum uterine fibroid diameter and volume increased after 3 months, 6 months and 1 year of dienogest treatment compared with those before treatment (P < 0.01). The maximum diameter and volume of the uterine adenomyoma increased after 3 months of dienogest treatment but decreased after 6 months and 1 year of treatment compared with those before treatment, but the difference was not significant (P > 0.05). Endometrial thickness and antigen 125 levels were significantly thinner and decreased, respectively, after dienogest treatment (P < 0.01). Pearson's correlation analysis revealed that the increase in uterine fibroid volume after 3 months of dienogest treatment was positively correlated with the basic uterine fibroid volume (r = 0.792, P < 0.01). Among 64 patients with dysmenorrhea, 63 experienced significant relief of dysmenorrhea after 6 months of treatment with dienogest, and all patients experienced significant relief of dysmenorrhea after 12 months. Patients were able to tolerate the drugs, with an average drug tolerance score of 8.73.
CONCLUSION
The use of dienogest in patients with endometriosis or adenomyosis combined with uterine fibroids can effectively relieve the patient's pain symptoms and significantly reduce the sizes of ovarian endometriotic cysts, but it cannot inhibit uterine fibroid growth.
Comparative study on emotional behavior and parental job stress of only-child and non-only-child preschool children
Authors: Fu Zhi-Wei , Wang Kai-Li , Du Ning-Yu , Li Yue-Jing , Duan Jing-Jing , Zhao Sheng-Xia 
Published: June 2024

BACKGROUND
Studies have revealed that Children's psychological, behavioral, and emotional problems are easily influenced by the family environment. In recent years, the family structure in China has undergone significant changes, with more families having two or three children.
AIM
To explore the relationship between emotional behavior and parental job stress in only preschool and non-only preschool children.
METHODS
Children aged 3-6 in kindergartens in four main urban areas of Shijiazhuang were selected by stratified sampling for a questionnaire and divided into only and non-only child groups. Their emotional behaviors and parental pressure were compared. Only and non-only children were paired in a 1:1 ratio by class and age (difference less than or equal to 6 months), and the matched data were compared. The relationship between children's emotional behavior and parents' job stress before and after matching was analyzed.
RESULTS
Before matching, the mother's occupation, children's personality characteristics, and children's rearing patterns differed between the groups (P < 0.05). After matching 550 pairs, differences in the children's parenting styles remained. There were significant differences in children's gender and parents' attitudes toward children between the two groups. The Strengths and Difficulties Questionnaire (SDQ) scores of children in the only child group and the Parenting Stress Index-Short Form (PSI-SF) scores of parents were significantly lower than those in the non-only child group (P < 0.05). Pearson’s correlation analysis showed that after matching, there was a positive correlation between children's parenting style and parents' attitudes toward their children (r = 0.096, P < 0.01), and the PSI-SF score was positively correlated with children's gender, parents' attitudes toward their children, and SDQ scores (r = 0.077, 0.193, 0.172, 0.222).
CONCLUSION
Preschool children's emotional behavior and parental pressure were significantly higher in multi-child families. Parental pressure in differently structured families was associated with many factors, and preschool children's emotional behavior was positively correlated with parental pressure.
Efficacy and safety of over-the-scope-clips in the therapy of acute nonvariceal upper gastrointestinal bleeding: Meta-analysis
Authors: Yang Xue-Zhu , Yu Dan-Li , Wang Zhi , Gao Zhi-Long 
Published: June 2024

BACKGROUND
Acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) is a frequent life-threatening acute condition in gastroenterology associated with high morbidity and mortality. Over-the-scope-clip (OTSC) is a new endoscopic hemostasis technique, which is being used in ANVUGIB and is more effective.
AIM
To summarize and analyze the effects of the OTSC in prevention of recurrent bleeding, clinical success rate, procedure time, hospital stay, and adverse events in the treatment of ANVUGIB, to evaluate whether OTSC can replace standard endoscopic therapy as a new generation of treatment for ANVUGIB.
METHODS
The literature related to OTSC and standard therapy for ANVUGIB published before January 2023 was searched in PubMed, Web of Science, EMBASE, Cochrane, Google, and CNKI databases. Changes in recurrent bleeding (7 or 30 days), clinical results (clinical success rate, conversion rate to surgery, mortality), therapy time (procedure time, hospital stay), and adverse events in the OTSC intervention group were summarized and analyzed, and the MD or OR of 95%CI is calculated by Review Manager 5.3.
RESULTS
This meta-analysis involved 11 studies with 1266 patients. Total risk of bias was moderate-to-high. For patients in the OTSC group, 7- and 30-days recurrent bleeding rates, as well as procedure time, hospital stay, and intensive care unit stay, were greatly inhibited. OTSC could significantly improve the clinical success rate of ANVUGIB. OTSC therapy did not cause serious adverse and was effective in reducing patient mortality.
CONCLUSION
OTSC may provide more rapid and sustained hemostasis, and thus, promote recovery and reduce mortality in patients with ANVUGIB. In addition, the safety of OTSC is assured.
Efficacy and safety of fecal microbiota transplantation for treatment of ulcerative colitis: A post-consensus systematic review and meta-analysis
Authors: Zhang Jin-Tao , Zhang Nan , Dong Xue-Tao , Wang Xiao-Ran , Ma Hong-Wen , Liu Yan-Di , Li Mu-Ran 
Published: June 2024

BACKGROUND
Numerous studies have assessed the efficacy and safety of fecal microbiota transplantation (FMT) as a therapy for ulcerative colitis (UC). However, the treatment processes and outcomes of these studies vary.
AIM
To evaluate the efficacy and safety of FMT for treating UC by conducting a systematic meta-analysis.
METHODS
The inclusion criteria involved reports of adult patients with UC treated with FMT, while studies that did not report clinical outcomes or that included patients with infection were excluded. Clinical remission (CR) and endoscopic remission (ER) were the primary and secondary outcomes, respectively.
RESULTS
We included nine studies retrieved from five electronic databases. The FMT group had better CR than the control group [relative risk (RR) = 1.53; 95% confidence interval (CI): 1.19-1.94; P < 0.0008]. ER was statistically significantly different between the two groups (RR = 2.80; 95%CI: 1.93-4.05; P < 0.00001). Adverse events did not differ significantly between the two groups.
CONCLUSION
FMT demonstrates favorable performance and safety; however, well-designed randomized clinical trials are still needed before the widespread use of FMT can be recommended. Furthermore, standardizing the FMT process is urgently needed for improved safety and efficacy.
Visual analysis of abdominal aortitis treatment using the CiteSpace bibliometric method
Authors: Guo Si-En , Meng Yuan-Biao , Zhang Zan-Man , Zhang Yu-Lan , Yao Qi-Sen , Qin Xiao 
Published: June 2024

BACKGROUND
Abdominal aortitis can induce aneurysms, and tumor rupture can lead to organ ischemia or even sudden death. At present, there is a lack of extensive understanding and identification of key problems in the treatment of abdominal aortitis, which needs to be further analyzed using bibliometric analysis.
AIM
To discuss the research hotspot and development trend of abdominal aortitis treatment.
METHODS
We searched the English literature (published from 1 January 2000 to 12 March 2024) on the treatment of abdominal aortitis in the Web of Science database. Then, we identified and screened duplicate literature using CiteSpace 6.1R2 software. We conducted an analysis of the number of papers, a co-occurrence analysis of the authors and institutions, and co-occurrence and cluster analyses of the keywords. Then, we drew the author, institution, and keywords of the studies into graphs for visualization. Finally, we expounded on the author, institutional network interactions, and hot keywords of the studies on the treatment of abdominal aortitis.
RESULTS
We included 210 English literature articles involving 190 authors; the author cooperation team was mainly represented by Caradu Caroline, Berard Xavier, Lu Guanyi, Harada Kenichi, and Sharma Ashish K. In the keyword analysis, high-frequency keywords include abdominal aortic aneurysm (38), abdominal aorta (24), Takayasu arteritis (22), etc . The three most central keywords were disease (0.69), classification (0.68), and abdominal aortic aneurysm (0.55). The first nine clusters of keywords are case report, abdominal aortic aneurysm, Takayasu arteritis, dyspnea hematuria, aortic elastic, IgG4-related disease, report, mid aortic dysplastic syndrome, and statin. In the keyword emergent analysis, 14 emergent words were obtained. Among them, seven keywords with strong abruptness were Takayasu arteritis, abdominal aortic aneurysm, disease, retroperitoneal fibrosis, expression, management, and large vessel vasculitis. In the past 3 years, the incidences of abdominal aortic aneurysm (intensity: 4.62) and inflammation (intensity: 1.99) were higher.
CONCLUSION
The number of published papers is on the increase, but the cooperation among authors is scattered. The research focus is mainly on the pathogenesis and treatment of abdominal aortitis-related diseases.
Trends and frontiers in signal amplification for aptamer-based tumor detection: A bibliometric analysis
Authors: Cai Dan , Chen Gui-Lin , Wang Ting , Zhang Kun-He 
Published: June 2024

BACKGROUND
Malignant tumors are one of the leading causes of death worldwide, imposing a substantial economic and social burden. Early detection is the key to improving cure rates and reducing mortality rates, which requires the development of sensitive early detection technologies. Signal amplification techniques play a crucial role in aptamer-based early detection of tumors and are increasingly garnering attention from researchers.
AIM
To investigate the current research status, developmental trajectories, and hotspots in signal amplification for aptamer-based tumor detection through bibliometric analysis.
METHODS
English publications pertaining to signal amplification in aptamer-based tumor detection were retrieved from the Web of Science Core Collection database. VOSviewer and CiteSpace software were employed to analyze various information within this field, including countries, institutions, authors, co-cited authors, journals, co-cited journals, cited references, and keywords.
RESULTS
A total of 757 publications were included in this study. China accounted for 85.47% of all publications, with Nanjing University (China) emerging as the institution with the highest publication output. The most influential authors and journals were Hasanzadeh M. from Iran and "Biosensors and Bioelectronics ", respectively. Exosomes and carcinoembryonic antigen (CEA) stood out as the most researched tumor-related molecules. Currently, the predominant signal amplification technique, nanomaterial, and signal transduction method were identified as hybridization chain reactions, gold nanoparticles, and electrochemical methods, respectively. Over the past 3 years, exosomes, CEA, electrochemical biosensors, and nanosheets have emerged as research hotspots, exhibiting a robust burst of intensity.
CONCLUSION
This study is the first bibliometric analysis of literature on signal amplification in aptamer-based tumor detection and elucidates the current status, hotspots, and prospective research directions within this realm. Additionally, it provides an important reference for researchers.
Torsed retroperitoneal leiomyomas: A case report and review of literature
Authors: Li Jin , Zhu-Ge Yi-Yi , Lin Kai-Qing 
Published: June 2024

BACKGROUND
Retroperitoneal leiomyomas (RLs) are rare benign tumours that can occur in the pelvic and/or abdominal parietal retroperitoneum. Once torsion occurs, it causes acute abdominal pain and can even lead to serious consequences such as gangrene, peritonitis, haemoperitoneum and shock if not identified and treated promptly. Therefore, a better understanding of the characteristics of RL torsion is needed. Here, we present a case of acute pedicle torsion of an RL in the posterior peritoneum followed by a literature review.
CASE SUMMARY
Herein, we report the case of a 42-year-old woman with RL torsion. The patient visited our hospital complaining of lower abdominal pain for 6 d. Pelvic examination revealed a tender mass superior to the uterus. Pelvic MRI revealed an anterior uterine mass, multiple uterine fibroids and slight pelvic effusion. MRI suggested the possibility of a subserosal myoma of the anterior uterine wall with degeneration. Intraoperative exploration revealed a 10 cm pedunculated mass arising from the posterior peritoneum, with the pedicle torsed two times. Pathological examination confirmed a torsed RL.
CONCLUSION
In the case of a pelvic mass complicated with acute abdomen, the possibility of torsion should be considered.
Only a Snowball’s Chance in Hell: Comment on A Call for Change in Healthcare Governance
Authors: Parides George 
Published: June 2024

Dr. Robbins’ is 100% correct of what should happen. The proposed changes would be great for patients and practitioners. Unfortunately, there is only a snowball’s chance in hell that any of these things could happen and here are my observations as to why. 1.	First, and foremost what is happening now is what the government, Centers for Medicare and Medicaid Services (CMS) and all hospital systems want to happen. They want full, and I mean FULL control of all physicians. It is why they reimburse physicians who work for hospitals (owned by hospitals) more than they do in private practice. They therefore control the votes for Chief of Staff as they are now a large majority of staff members fully owned and because they won't risk their incomes they will vote as told. A private physician has little chance in these elections. 2.	Second, when you call on the Joint ...
Antibacterial and Antiviral Potential of Zirconium Oxide Nanoparticle using Extract of Chloranthus erectus Leaf
Authors: Hasan Nor' Aishah , Wazir Nurul Natasha , Zainal-Abidin Nurhamimah , Nawahwi Mohd Zaini , Badrol Hisham Nurul Atikah , Yasin Yamin , Nik Masdek Nik Rozlin , Khairat Jasmine Elanie , Yu Lim Zhi , Azzeme Azzreena Mohamad , Arief Syukri , Putri Gusliani Eka , Ahmad Nor Monica 
Published: June 2024

Zirconium oxide nanoparticles (ZrO2 NPs) were synthesized with an effective capping agent using aqueous extract of Chlorentus erectus at the optimized conditions. The aqueous leaf extract contained phytochemical compounds that could regulate the size and shape of the nanoparticles. The average size of C. erectus-ZrO2 NPs crystallite was 10.42 nm, which was determined based on Scherrer Debye’s equation. The finding indicated the effectiveness of the phytochemical compounds to diminish the agglomeration of the particles. The C. erectus mediated ZrO2 NPs were in spherical clusters when observed through a transmission electron microscope (TEM). An elemental energy diffraction X-ray (EDX) assessment also revealed a significant zirconium and oxygen percentage, suggesting that the phytochemicals present in the leaf extract did not alter the purity of C. erectus-ZrO2 NPs. Moreover, 200 µg/mL of synthesized ZrO2 NPs effectively inhibited K. pneumoniae. Up to 300 µg/mL of C. erectus- ZrO2 NPs demonstrated non-toxicity to vero cells and low antiviral properties against the DENV-2 virus when introduced to cells post-infection.
Differential hemodynamic adaptations to tilt test in patients with idiopathic atrial fibrillation
Authors: Magajevski Adriano Senter , Távora‐Mehta Maria Zildany P. , Mehta Niraj , Maluf Débora L. Smith , Silva Edvaldo C. Pinheiro , Concato Leticia , Ortiz Marcio Rogerio , Doubrawa Eduardo , Lofrano‐Alves Marco Stephan 
Published: June 2024

AbstractThe hemodynamic response during the transition from the supine to standing position in idiopathic atrial fibrillation (AF) patients is not completely understood. This study aimed to analyze the hemodynamic changes that occur during the head‐up tilt test in idiopathic AF patients. We investigated the hemodynamic changes during the head‐up tilt test with impedance cardiography in 40 AF patients (12 with AF rhythm‐AFr and 28 with sinus rhythm‐AFsr) and 38 non‐AF controls. Patients with AFr had attenuated SVI decrease after standing when compared to AFsr and non‐AF [ΔSVI in mL/m2: −1.3 (−3.4 to 1.7) vs. −6.4 (−17.3 to −0.1) vs. −11.8 (−18.7 to −8.0), respectively; p < 0.001]. PVRI decreased in AFr but increased in AFsr and non‐AF [ΔPVRI in dyne.seg.m2/cm5: −477 (−1148 to 82.5) vs. 131 (−525 to 887) vs. 357 (−29 to 681), respectively; p < 0.01]. Similarly, compared with non‐AF patients, AFr patients also had a greater HR and greater CI increase after standing. The haemodynamic response to orthostatic challenge suggests differential adaptations between patients with AF rhythm and those reverted to sinus rhythm or healthy controls. Characterizing the hemodynamic phenotype may be relevant for the individualized treatment of AF patients.
Hybrid classical-Bayesian approach to sample size determination for two-arm superiority clinical trials
Authors: Sambucini Valeria 
Published: June 2024

Abstract
Traditional methods for Sample Size Determination (SSD) based on power analysis exploit relevant fixed values or preliminary estimates for the unknown parameters. A hybrid classical-Bayesian approach can be used to formally incorporate information or model uncertainty on unknown quantities by using prior distributions according to the Bayesian approach, while still analysing the data in a frequentist framework. In this paper, we propose a hybrid procedure for SSD in two-arm superiority trials, that takes into account the different role played by the unknown parameters involved in the statistical power. Thus, different prior distributions are used to formalize design expectations and to model information or uncertainty on preliminary estimates involved at the analysis stage. To illustrate the method, we consider binary data and derive the proposed hybrid criteria using three possible parameters of interest, i.e. the difference between proportions of successes, the logarithm of the relative risk and the logarithm of the odds ratio. Numerical examples taken from the literature are presented to show how to implement the proposed procedure.
Correlation of single-fiber electromyography studies and functional status in patients with amyotrophic lateral sclerosis
Authors: Rostás Róbert , Fekete István , Horváth László , Márton Sándor , Fekete Klára 
Published: June 2024

Abstract

Objective
Our aim was to examine the significance of single-fiber electromyography (SFEMG) in patients diagnosed with amyotrophic lateral sclerosis (ALS) and determine the best correlating parameter with SFEMG parameters and clinical scales across different muscles including facial muscles.

Methods
SFEMG examinations were conducted on the extensor digitorum (ED), frontalis, and orbicularis oculi muscles. Mean jitter, percentage of increased jitter, fiber density (FD), and impulse blocking percentage were compared to reference values and functional scales.

Results
Significant differences (p < 0.001) were observed between the patients’ SFEMG results and reference values in all muscles. Significant correlations were found between SFEMG parameters and clinical scales, particularly when considering both FD and jitter. A notable value of the ALS Functional Rating Scale Revised (ALSFRS-R) was detected in all muscles: 31 points in the ED muscle, 30 in the orbicularis oculi muscle, and 31 in the frontalis muscle. Below this ALSFRS-R threshold, the percentage of increased jitter was higher, while FD remained relatively low.

Conclusion
SFEMG examination emerges as a valuable tool for better understanding ALS and holds potential for assessing prognosis. Combined jitter and FD analysis showed the strongest correlation with clinical scales. In addition to the ED muscle, the orbicularis oculi muscle may be important in the assessment.
Comparative study of couple stress fluid flow using OHAM and NIM
Authors: Farooq Muhammad , Nawaz Rashid , Khan Alamgeer , Younis Bakri Adam , DawAlbait Fathi Mohammed , Ismail Gamal M. 
Published: June 2024

Abstract
In this article, the plane Poiseuille flow of couple stress fluid of Vogel’s model between two parallel plates under the influence of non-isothermal effects have been investigated using Optimal homotopy asymptotic method (OHAM) and New iterative method (NIM). The governing continuity and momentum equations are transformed to ordinary differential equations and the coupled system of differential equations is then explored using the said methods. The expressions for velocity profile, temperature distribution, average velocity, volume flux, and shear stress have been obtained employing the said methods. Various essential flow properties have been presented and discussed. The results acquired via these techniques are in the form of infinite series; thus, the results can be effortlessly calculated. Comparison of both techniques are illustrated with the help of different tables and graphs and found both methods to be in a good agreement. Consequently, it will be more appealing for the investigators to apply the proposed methods to diverse problems arising in fluid dynamics.
Subjektivitas Najib Kailani dalam Cerpen Udara yang Dingin
Authors: Andika Kenny 
Published: June 2024

The short story Udara yang Dingin is Najib Kailani's criticism of the patriarchal culture that positions women under the control of men. This research discusses the subjectivity of characters and authors within the scope of the short story Udara yang Dingin by Najib Kailani using Slavoj Zizek's theory of Subjectivity. Zizek's view is that humans can achieve their freedom and purity by letting go of the entangling symbolic towards the wholeness that is longed for in the real. Conversely, humans will be in a symbolic trap as long as they allow themselves to be trapped in the circle of ideological false consciousness. This research shows that there is a radical effort made by Fatimah's character to release herself from the symbolic by breaking the normative rules that surround her. However, the radical action taken by Fatimah in this short story is not carried out by Najib Kailani, who is only immersed in ideological fantasies.