bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paclitaxel improved anti-L1CAM lutetium-177 radioimmunotherapy in an ovarian cancer xenograft model
Authors: Lindenblatt Dennis , Fischer Eliane , Cohrs Susan , Schibli Roger , Grünberg Jürgen 
Published: October 2014

Abstract

Background
Today's standard treatment of advanced-stage ovarian cancer, including surgery followed by a paclitaxel-platinum-based chemotherapy, is limited in efficacy. Recently, we could show that radioimmunotherapy (RIT) with 177Lu-labelled anti-L1 cell adhesion molecule (L1CAM) monoclonal antibody chCE7 is effective in ovarian cancer therapy. We investigated if the efficacy of anti-L1CAM RIT can be further improved by its combination with paclitaxel (PTX).

Methods

In vitro cell viability and cell cycle arrest of human ovarian cancer cells were assessed upon different treatment conditions. For therapy studies, nude mice (n = 8) were injected subcutaneously with IGROV1 human ovarian carcinoma cells and received a single dose of 6 MBq 177Lu-DOTA-chCE7 alone or in combination with 600 μg PTX (31.6 mg/kg). Tumour growth delay and survival were determined. To investigate whether PTX can influence the tumour uptake of the radioimmunoconjugates (RICs), a biodistribution study (n = 4) and SPECT/CT images were acquired 120 h post injections of 2 MBq 177Lu-DOTA-chCE7 alone or in combination with 600 μg PTX.

Results
Lu-DOTA-chCE7 in combination with PTX revealed a significantly decreased cell viability of ovarian carcinoma cells in vitro and was effective in a synergistic manner (combination index < 1). PTX increased the RIT efficacy by arresting cells in the radiosensitive G2/M phase of the cell cycle 24 h post treatment start. In vivo combination therapy including 177Lu-DOTA-chCE7 and PTX resulted in a significantly prolonged overall survival (55 days vs. 18 days/PTX and 29 days/RIT), without weight loss and/or signs of toxicity. Biodistribution studies revealed no significant difference in tumour uptakes of 177Lu-DOTA-chCE7 72 h post injection regardless of an additional PTX administration.

Conclusions
Combination of anti-L1CAM 177Lu-RIT with PTX is a more effective therapy resulting in a prolonged overall survival of human ovarian carcinoma-bearing nude mice compared with either monotherapy. The combination is promising for future clinical applications.
Syntheses and Structures of Molybdenum-Oxo Complexes Prepared by the Reactions of [MoII2(OAc)4] with tert-Butyl- or Bromo-Substituted Catechols
Authors: Matsumoto Takeshi , Yano Hirokazu , Wakizaka Masanori , Kobayashi Atsushi , Kato Masako , Chang Ho-Chol 
Published: October 2014

Abstract
The reactions of [MoII2(OAc)4] (OAc−: acetato) with catecholato derivatives (R-Cat2−), possessing electron-donating t-Bu groups (3,6-DTBCat2−) or electron-withdrawing Br groups (Br4Cat2−), results in the formation of a mononuclear complex [Na(THF)6][MoV(3,6-DTBCat)3] (1) and a dinuclear complex either [Na6(Br4SQ)2][MoIV2(µ-O)2(Br4Cat)4] or [Na6(Br4Cat)2][MoV2(µ-O)2(Br4Cat)4] (3). Complex 3 has a [Mo(µ-O)2Mo] core as part of a dimer of [O=Mom(Br4Cat)2]n− (m = IV or V, n = 2 or 1) moieties assembled in a head-to-tail arrangement, which has been structurally characterized as the a bis-µ-oxo molybdenum dinuclear complex containing catecholato ligands. The bond distance between the Mo atoms (2.4286(17) Å) strongly suggests that a MoIV=MoIV or MoV–MoV bonding character exists in 3. Differences in the substituent groups on the catecholato ligand affect not only the product formed but also the reactivity of both complexes. Complex 3 shows O-atom abstraction reactivity with dimethyl sulfoxide (DMSO) and forms dimethyl sulfide (DMS). These results support a high oxophilicity of the Mo center in 3.
Concise Synthesis of 6-Formylindolo[3,2-b]carbazole (FICZ)
Authors: Sekine Daisuke , Okeda Shota , Hosokawa Seijiro 
Published: October 2014

Abstract
A concise synthesis of 6-formylindolo[3,2-b]carbazole (FICZ), a potent ligand of the aryl hydrocarbon receptor (AhR), has been established. The conjugate addition of the enolate derived from indolylacetate 2 to 2-chloro-3-formylindole 3 was accomplished. The following cyclization reaction under the acidic conditions gave the indolo[3,2-b]carbazole skeleton.
German Jewish Émigrés and US Invention
Authors: Moser Petra , Voena Alessandra , Waldinger Fabian 
Published: October 2014

Historical accounts suggest that Jewish émigrés from Nazi Germany revolutionized US science. To analyze the émigrés' effects on chemical innovation in the United States, we compare changes in patenting by US inventors in research fields of émigrés with fields of other German chemists. Patenting by US inventors increased by 31 percent in émigré fields. Regressions which instrument for émigré fields with pre-1933 fields of dismissed German chemists confirm a substantial increase in US invention. Inventor-level data indicate that émigrés encouraged innovation by attracting new researchers to their fields, rather than by increasing the productivity of incumbent inventors. (JEL J15, L65, N62, O31, O34)
Characterization of population-based variation and putative functional elements for the multiple-cancer susceptibility loci at 5p15.33
Authors: Mirabello Lisa , Chung Charles C. , Yeager Meredith , Savage Sharon A 
Published: October 2014

Background:TERTencodes the telomerase reverse transcriptase, which is responsible for maintaining telomere ends by addition of (TTAGGG)nnucleotide repeats at the telomere. Recent genome-wide association studies have found common genetic variants at theTERT-CLPTM1Llocus (5p15.33) associated with an increased risk of several cancers. Results:Data were acquired for 1627 variants in 1092 unrelated individuals from 14 populations within the 1000 Genomes Project. We assessed the population genetics of the 5p15.33 region, including recombination hotspots, diversity, heterozygosity, differentiation among populations, and potential functional impacts. There were significantly lower polymorphism rates, divergence, and heterozygosity for the coding variants, particularly for non-synonymous sites, compared with non-coding and silent changes. Many of the cancer-associated SNPs had differing genotype frequencies among ancestral groups and were associated with potential regulatory changes. Conclusions:Surrogate SNPs in linkage disequilibrium with the majority of cancer-associated SNPs were functional variants with a likely role in regulation ofTERTand/orCLPTM1L. Our findings highlight several SNPs that future studies should prioritize for evaluation of functional consequences.
Increased Rheumatoid Factor and Deep Venous Thrombosis: 2 Cohort Studies of 54628 Individuals from the General Population
Authors: Meyer-Olesen Christine L , Nielsen Sune F , Nordestgaard Børge G 
Published: October 2014

Abstract

BACKGROUND
The risk of deep venous thrombosis is increased in patients with rheumatoid arthritis. We tested the hypothesis that increased concentrations of rheumatoid factor are associated with increased risk of deep venous thrombosis in individuals without autoimmune rheumatic disease in the general population.

METHODS
We included 54628 participants from the Copenhagen City Heart Study (1981–83) and the Copenhagen General Population Study (2004–12), all with a measured concentration of IgM rheumatoid factor and without autoimmune rheumatic disease or venous thromboembolism. The main outcome was incident deep venous thrombosis. There were no losses to follow-up.

RESULTS
During 368381 person-years, 670 individuals developed deep venous thrombosis. A rheumatoid factor concentration ≥ vs &lt;110 IU/mL showed the strongest association with deep venous thrombosis, with multivariable adjusted hazard ratios of 9.0 (95% CI 3.1–26) for 1-year follow-up, 4.3 (2.2–8.5) for 5-year follow-up, and 3.1 (1.7–5.6) for up to 32 years of follow-up. Compared with rheumatoid factor concentrations &lt;15 IU/mL, the multivariable adjusted hazard ratios for deep venous thrombosis during maximum follow-up were 1.3 (1.0–1.5) for 15–29 IU/mL, 1.7 (1.0–2.8) for 30–59 IU/mL, 2.4 (1.3–4.3) for 60–119 IU/mL, and 3.0 (1.6–5.6) for ≥120 IU/mL (trend P = 6 × 10−7). Results were similar in the 2 studies separately. Obese men and women age &gt;60 years with rheumatoid factor concentrations ≥120 IU/mL had 10% and 8% 5-year risk of deep venous thrombosis.

CONCLUSIONS
Increased rheumatoid factor in the general population was associated with up to 3-fold increased long-term risk and up to 9-fold increased 1-year risk of deep venous thrombosis.
‘Right you are (if you think so)’: The sociolinguistic construction of youth identity in a Greek family sitcom
Authors: Stamou Anastasia G. , Saltidou Theodora P. 
Published: October 2014

Abstract
This article examines the ways in which the sociolinguistic construction of youth identity takes place in the popular Greek family sitcom Deka Lepta Kirigma/ Ten-Minute Preaching (Mega TV, 2000–04). Drawing on the ‘identities in interaction’ sociocultural linguistic model of Bucholtz and Hall (2005) and the ethno-methodological tool of ‘membership categorization analysis’ (Sacks 1992), our analysis focuses on three interactions between teenage and adult characters in the show. As we demonstrate, each of the analysed characters constructs themselves and others through identity categories that the other conversationalists attempt to contest and denaturalize. This suggests that, unlike other similar mainstream media texts which firmly adopt an adult perspective on young people, Ten-Minute Preaching is more ambivalent in its portrayal of youth through the characters’ talk, since it includes both teenage and adult voices, conveying the message that there are multiple and even conflicting versions of reality, depending on the perspective from which one sees it. Our analysis, however, demonstrates that the show eventually supports the stereotypical view that adults have of young people and their style of talk, as it sees them through the prism of the generation gap, a key theme that has traditionally defined the adult-constructed discourse of adolescence, which has structured mainstream media texts historically.
Headbanging in Nairobi: The emergence of the Kenyan metal scene and its transformation of the metal code
Authors: Knopke Ekkehard 
Published: October 2014

Abstract
In this article, I discuss the development and structures of Kenyan metal culture. In doing so, I show that this local metal culture is dependent on an urban setting that provides electricity, performing venues and the Internet. Furthermore, a growth period is encountered that is characterized by a slowly increasing structural complexity. Additionally, I outline the idea of a metal subject in general and a Kenyan metal subject in particular. Therefore, I follow a praxeological approach that shows that, even if the Kenyan metalheads’ aim is to reproduce the social practices of the global metal culture, new forms of metal practices are thereby produced and the so-called metal code is transformed. I conclude this article by proposing the idea of four transformative boundaries that lead to the emergence of a genuinely Kenyan metal sound. These boundaries are communicational and technological boundaries, boundaries of skill as well as boundaries of local culture.
The Metal King: Alexander the Great in heavy metal music
Authors: Djurslev Christian Thrue 
Published: October 2014

Abstract
Why are heavy metal bands so interested in the figure of Alexander the Great? The present article develops the argument that there are two overshadowing reasons: (1) the bands reconstruct the figure as a symbol of masculine power and communal unity; and (2) Alexander becomes part of a larger tradition already at an early stage of heavy metal’s history that many bands were interested in maintaining and revisiting. Several heavy metal tracks about him are explored and examined to substantiate this hypothesis. It is shown how these tracks associate him with a number of interrelated, recurring themes, such as conquest, community, imperialism, legacy, masculinity, nationalism, power and unity. These in turn help to project him as a figurehead of warrior virtues and also as a heroic bringer of culture. This is particularly true for Greek heavy metal bands, and their contribution is analysed at length. It is demonstrated how Greek metal songs also offer an intriguing insight into Greece’s political conflicts. Finally, it is suggested that, in his role as a powerful culture-hero and king, Alexander is capable of becoming an allegory for heavy metal itself.
Determinants of the production of heavy metal music
Authors: Maguire Donald 
Published: October 2014

Abstract
This study examines 55 independent variables to determine which ones relate to the formation of heavy metal bands. Certain demographic and economic factors can be identified through multi-variable regression analysis to be robust determinants of the number of heavy metal bands per capita in each country in 2012. The robust determinants identified in this study are: the percentage of the population that is Catholic, the percentage of the population with no religion, the latitude of the country, whether the country has a Scandinavian legal history, the number of years that the country was under Marxist rule, the percentage of the population that are males between the ages of 15 and 24, and the number of concert halls per 1 million people.
Reviews
Authors: Riches Gabby , Hill Rosemary Lucy , O’Boyle Tom , Stephanou Aspasia , Thibodeau Anthony J. , Scott Niall W. R. 
Published: October 2014

Abstract
From cultural politics to pleasurable affects: Female metal scholarship’s contribution to metal studies
Death Metal and Music Criticism: Analysis at the Limits, Michelle Phillipov (2012) Lanham: Lexington Books (172 pp.), ISBN: 9780739164594, Hardback, £35.85 ISBN: 9780739197608, Paperback, £24.12
Affective Intensities in Extreme Music Scenes: Cases from Australia and Japan, Rosemary Overell (2014) Basingstoke: Palgrave Macmillan (224 pp.), ISBN: 9781137406767, Hardback, $90/£53
Why Music Matters, David Hesmondhalgh (2013) Chichester: Wiley-Blackwell (204 pp.), ISBN: 9781405192415, Paperback, £19.99
Heavy Metal: Controversies & Countercultures, Titus Hjelm, Keith Kahn-Harris, Mark Levine (eds) (2013) Sheffield, UK: Equinox Publishing (260 pp.), ISBN-10: 1845539412, Hardback, £55.55, ISBN-13: 9781845539142, Paperback, £19.99
Black Metal: Evolution of the Cult, Dayal Patterson (2013) Washington: Feral House (485 pp.), ISBN: 9781936239757, Paperback, £19.99
Underground Never Dies! It is Not Black and White Anymore!, Andrés Padilla (2013) Santiago, Chile: Doomentia Press (505 pp.), no ISBN, Hardback, €48.00
Death Metal Epic I: The Inverted Katabasis, Dean Swinford (2013) Dayton, Ohio: Atlatl Press (160pp.), ISBN-10: 0988348438; ISBN-13: 9780988348431, Paperback, £7.99
Amalgamated anecdotes: Perspectives on the history of metal music and culture studies
Authors: Hickam Brian 
Published: October 2014

Abstract
Metal music and culture studies has witnessed rapid growth since its first international scholarly conference in 2008. Six years later, there are regular conferences and symposia; the International Society for Metal Music Studies (ISMMS); a refereed journal; archives of primary sources; a comprehensive bibliography; and robust scholarly communication. This article examines the history, status and future of metal studies. Through interviews with several key players, the story of ‘how’ and ‘why’ this new field of study emerged is illustrated.
Predictors of communal formation in a small heavy metal scene: Puerto Rico as a case study
Authors: Varas-Díaz Nelson , Rivera-Segarra Eliut , Medina Carmen L. Rivera , Mendoza Sigrid , González-Sepúlveda Osvaldo 
Published: October 2014

Abstract
Heavy metal music has constantly been under scrutiny due to its perceived negative effects on its listeners. Quantitative research has focused on heavy metal music as a risk factor for mental health problems and antisocial behaviour. This research agenda has neglected to explore and quantitatively document how the music can foster positive outcomes among its listeners, in particular a strong sense of community. Fans and producers of heavy metal music constantly reference community as an important aspect of the sonic experience. Still, few studies have addressed the communal experience in heavy metal music from a quantitative perspective. Therefore, the specific aims of this study were to (1) document levels of sense of community among members of the Local Metal Scene (LMS) in Puerto Rico, (2) explore differences on sense of community among core scene members and those at its periphery, and (3) explore predictive variables that can explain sense of community among its members. We present data from a larger study of the metal scene in Puerto Rico, which used a mixed methods approach including ethnographic observations, qualitative interviews and surveys with members of Puerto Rico’s metal scene. Results evidence high levels of sense of community, with existing differences among members of the same scene. Furthermore, our results identify six predictive variables of importance for sense of community among the LMS in Puerto Rico.
Examining consumer acceptance of green innovations using innovation characteristics: A conceptual approach
Authors: Kapoor Kawaljeet Kaur , Dwivedi Yogesh K. , Williams Michael D. 
Published: October 2014

Abstract
In the wake of global warming and environmental preservation, all processes and actions are now being directed along the lines of creating a greener environment. Household solar equipments are one such initiative, whereby people around the world are being encouraged to adopt green innovations even within homes. Recent emphasis is particularly along the usage of solar energy for home lighting, heating and cooking. To achieve increased adoption of these green innovations, it is important to understand the behaviours of various factors that may influence consumers in forming favourable intentions towards such innovations. This article aims to develop a theory-based conceptual framework for examining user adoption of household solar innovations. Attributes from Rogers’ Diffusion of Innovations theory, Tornatzky and Klein’s Meta-Analysis, and Moore and Benbasat’s Perceived Characteristics of Innovating theory will be used to design the intended framework for examining the adoption of household solar and other green innovations.
Non-invasive prenatal diagnosis of monogenic disorders: an optimized protocol using MEMO qPCR with miniSTR as internal control
Authors: Guissart Claire , Debant Vanessa , Desgeorges Marie , Bareil Corinne , Raynal Caroline , Toga Caroline , Pritchard Victoria , Koenig Michel , Claustres Mireille , Vincent Marie-Claire 
Published: October 2014

AbstractAnalysis of circulating cell-free fetal DNA (cffDNA) in maternal plasma is very promising for early diagnosis of monogenic diseases. However, this approach is not yet available for routine use and remains technically challenging because of the low concentration of cffDNA, which is swamped by the overwhelming maternal DNA.To make clinical applications more readily accessible, we propose a new approach based on mutant enrichment with 3′-modified oligonucleotides (MEMO) PCR along with real-time PCR to selectively amplify from the maternal blood the paternally inherited fetal allele that is not present in the maternal genome.The first proof of concept of this strategy was displayed for cystic fibrosis by the accuracy of our detection of the p.Gly542* mutation used as the initial developmental model. Subsequently, a retrospective study of plasmas originating from two pregnant women carrying a fetus with private mutation confirmed the effectiveness of our method. We confirmed the presence of cffDNA in the studied samples by the identification of a tri-allelic DNA profile using a miniSTR kit.This new non-invasive prenatal diagnosis test offers numerous advantages over current methods: it is simple, cost effective, time efficient and does not require complex equipment or bioinformatics settings. Moreover, our assays for different private mutations demonstrate the viability of this approach in clinical settings for monogenic disorders.
Immunoassay of thyroid peroxidase autoantibodies: diagnostic performance in automated third generation methods. A multicentre evaluation
Authors: D’Aurizio Federica , Tozzoli Renato , Villalta Danilo , Pesce Giampaola , Bagnasco Marcello 
Published: October 2014

AbstractThe use of automated immunometric methods for the detection of anti-thyroid peroxidase antibodies (TPOAb), the main serological marker of autoimmune thyroid diseases (AITD), has expanded in recent years. However, it is not known whether these new automated platforms have improved the diagnostic performance of TPOAb assays. The aim of this study was to evaluate the potential improvement of the inter-method agreement of current automated third generation systems, 12 years after a previous study, which had assessed the analytical variability between semi-automated second generation methods of TPOAb detection.Eight pools of sera from patients with chronic lymphocytic thyroiditis, exhibiting different TPOAb concentrations, were collected from routine laboratory diagnostics and distributed to seven companies throughout Italy. All automated third generation methods were calibrated against the Medical Research Council (MRC) reference preparation 66/387.The overall mean variability (CV) was 93.6% when results were expressed in part as arbitrary Units (U/mL) and in part as International Units (IU/mL). The conversion of all values in IU/mL resulted in a significant decrease of CV (49.8%). The CV expressed as COM (cut-off concentration multiples) was 64.0%. Agreement of qualitative results was 95.3% with a pronounced difference in the threshold values proposed by manufacturers (range 3.2–35.0 IU/mL).These findings confirm the improvement of harmonisation between different methods of automated third generation TPOAb assays. Nevertheless, further efforts should be made in the definition of the positive cut-off concentration to avoid misclassification of AITD patients as well as in a new international reference preparation and in the autoantigen purification modality.
Nietzsche 1914 – eine Philosophie für die Front?
Authors: Zimmermann Rolf 
Published: October 2014

Abstract
During World War I Nietzsche, on the one hand, was blamed for German militarism in Anglo-American and French writings, and, on the other hand, became celebrated as a spiritual hero of German culture and greatness. This essay delivers a critique of simplistic images of Nietzsche’s philosophy in the context of war by analyzing essentials of his mature work (“will to power” etc.). Additionally, the German intellectual scene is confronted with Nietzsche’s denouncement of nationalism, anti-Semitism, Christianity, socialism in order to deny the existence of a definitive Nietzschean war position. Finally, Nietzsche’s European idea is reflected in light of Max Weber’s comments on World War I and his political theory. The essay concludes that the problem of how to relate philosophical thinking to realities of historical development deserves further inquiry.
Jenseits der Regelbefolgung. Metaethische Konsequenzen der Legalismus-Kritik Judith Shklars
Authors: Hetzel Andreas 
Published: October 2014

Abstract
In my paper I reconstruct J. Shklar’s arguments against legalistic positions which try to reduce the moral point of view to a model of legitimizing and applying rules. I emphasize in particular the relevance of her arguments for current metaethical debates. The paper shows that Shklar’s thought comes close to some arguments of S. Cavell, who locates the problem of how to define the relation between a rule and a case at the very center of ethical reflection. Finally I discuss how Shklar’s scepticism about any objective moral point of view corresponds with two other negativistic motives of her philosophy: a) her accusation that traditional theories of justice make invisible the perspective of the victims of injustice, and b) her thesis that injustice cannot be reduced to “a prelude, a rejection, and a collapse of justice.”