bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphine‐Catalyzed β,γ‐Umpolung Domino Reaction of Allenic Esters: Facile Synthesis of Tetrahydrobenzofuranones Bearing a Chiral Tetrasubstituted Stereogenic Carbon Center
Authors: Takizawa Shinobu , Kishi Kenta , Yoshida Yasushi , Mader Steffen , Arteaga Fernando Arteaga , Lee Shoukou , Hoshino Manabu , Rueping Magnus , Fujita Makoto , Sasai Hiroaki 
Published: November 2015

AbstractAn enantio‐, diastereo‐, regio‐, and chemoselective phosphine‐catalyzed β,γ‐umpolung domino reaction of allenic esters with dienones has been developed for the first time. The designed sequence, involving oxy‐Michael and Rauhut–Currier reactions, produced highly functionalized tetrahydrobenzofuranones, bearing a chiral tetrasubstituted stereogenic center, in up to 96 % ee.
Metal‐Free Ammonia–Borane Dehydrogenation Catalyzed by a Bis(borane) Lewis Acid
Authors: Lu Zhenpin , Schweighauser Luca , Hausmann Heike , Wegner Hermann A. 
Published: November 2015

AbstractThe storage of energy in a safe and environmentally benign way is one of the main challenges of today’s society. Ammonia–borane (AB=NH3BH3) has been proposed as a possible candidate for the chemical storage of hydrogen. However, the efficient release of hydrogen is still an active field of research. Herein, we present a metal‐free bis(borane) Lewis acid catalyst that promotes the evolution of up to 2.5 equivalents of H2 per AB molecule. The catalyst can be reused multiple times without loss of activity. The moderate temperature of 60 °C allows for controlling the supply of H2 on demand simply by heating and cooling. Mechanistic studies give preliminary insights into the kinetics and mechanism of the catalytic reaction.
An Enantiopure Hydrogen‐Bonded Octameric Tube: Self‐Sorting and Guest‐Induced Rearrangement
Authors: Račkauskaitė Dovilė , Gegevičius Rokas , Matsuo Yutaka , Wärnmark Kenneth , Orentas Edvinas 
Published: November 2015

AbstractThe assembly of a discrete hydrogen‐bonded molecular tube from eight small identical monomers is reported. Tube assembly was accomplished by means of selective heterodimerization between isocytosine and ureidopyrimidinone hydrogen‐bonding motifs embedded in an enantiopure bicyclic building block, leading to the selective formation of an octameric supramolecular tube. Upon introduction of a fullerene guest molecule, the octameric tube rearranges into a tetrameric inclusion complex and the hydrogen‐bonding mode is switched. The dynamic behavior of the system is further explored in solvent‐ and guest‐responsive self‐sorting experiments.
Ligand‐Enabled Catalytic CH Arylation of Aliphatic Amines by a Four‐Membered‐Ring Cyclopalladation Pathway
Authors: He Chuan , Gaunt Matthew J. 
Published: November 2015

AbstractA palladium‐catalyzed CH arylation of aliphatic amines with arylboronic esters is described, proceeding through a four‐membered‐ring cyclopalladation pathway. Crucial to the successful outcome of this reaction is the action of an amino‐acid‐derived ligand. A range of hindered secondary amines and arylboronic esters are compatible with this process and the products of the arylation can be advanced to complex polycyclic molecules by sequential CH activation reactions.
A course‐based undergraduate research experience investigating p300 bromodomain mutations
Authors: Shanle Erin K. , Tsun Ian K. , Strahl Brian D. 
Published: November 2015

AbstractCourse‐based undergraduate research experiences (CUREs) provide an opportunity for students to engage in experiments with outcomes that are unknown to both the instructor and students. These experiences allow students and instructors to collaboratively bridge the research laboratory and classroom, and provide research experiences for a large number of students relative to traditional individual mentored research. Here, we describe a molecular biology CURE investigating the impact of clinically relevant mutations found in the bromodomain of the p300 transcriptional regulator on acetylated histone interaction. In the CURE, students identified missense mutations in the p300 bromodomain using the Catalogue of Somatic Mutations in Cancer (COSMIC) database and hypothesized the effects of the mutation on the acetyl‐binding function of the domain. They cloned and purified the mutated bromodomain and performed peptide pulldown assays to define its potential to bind to acetylated histones. Upon completion of the course, students showed increased confidence performing molecular techniques and reported positively on doing a research project in class. In addition, results generated in the classroom were further validated in the research laboratory setting thereby providing a new model for faculty to engage in both course‐based and individual undergraduate research experiences. © 2015 by The International Union of Biochemistry and Molecular Biology, 44:68–74, 2016.
Online identity construction: How gamers redefine their identity in experiential communities
Authors: Costa Pinto Diego , Reale Getúlio , Segabinazzi Rodrigo , Vargas Rossi Carlos Alberto 
Published: November 2015

AbstractThis research aims to understand how gamers redefine their identity by extending, aggregating, and assembling the different dimensions of the self in experiential online communities. The authors conducted a series of filmed in‐depth and in game individual interviews, group interviews, informal conversations, and observation of online game sessions. A framework of online identity construction shows how gamers assemble their identities combining different self‐dimensions, using two different strategies: self‐extension and self‐aggregation. Self‐extension strategies consist in the idealization, development, and manipulation of avatars (their digital self). Self‐aggregation strategies refer to group participation and sharing virtual possessions within groups of players. To bring their identities from the experiential community to the real life, gamers combine these strategies by assembling and materializing identities. This framework has theoretical implications for the self, identity, and sharing in online contexts. Finally, the paper considers managerial implications and future research directions in online communities. Copyright © 2015 John Wiley & Sons, Ltd.
Electrogenerated Chemiluminescence of Cationic Triangulene Dyes: Crucial Influence of the Core Heteroatoms
Authors: Adam Catherine , Wallabregue Antoine , Li Haidong , Gouin Jérôme , Vanel Rémi , Grass Stéphane , Bosson Johann , Bouffier Laurent , Lacour Jérôme , Sojic Neso 
Published: November 2015

AbstractTrianguleniums are fascinating conjugated hexacyclic cations that exhibit interesting electronic and optical properties. Herein, the electrogenerated chemiluminescence (ECL) emission of this family of fluorescent dyes is reported for the first time. Redox behavior and fluorescence properties of eight cationic triangulene luminophores with different heteroatom patterns in the core structure and various pending substituents were examined to rationalize the ECL. Clearly, the more electron‐rich the carbocation, the more efficient the corresponding ECL; two very distinct classes of triangulenes can be drawn from these studies by using an ECL wall sufficiency formalism.
Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring
Authors: Lo Re Daniele , Zhou Ying , Mucha Joanna , Jones Leigh F. , Leahy Lorraine , Santocanale Corrado , Krol Magdalena , Murphy Paul V. 
Published: November 2015

AbstractInvited for the cover of this issue are Paul V. Murphy and co‐workers at the National University of Ireland Galway (NUI Galway) and Warsaw University. The image depicts MGSTA‐6 giving a stop signal to tumour cells that are on the move. Read the full text of the article at 10.1002/chem.201502861.
Development and Validation of the Morphing Fear Questionnaire (MFQ)
Authors: Zysk Eva , Shafran Roz , Williams Tim I. , Melli Gabriele 
Published: November 2015

Morphing fears (also called transformation obsessions) involve concerns that a person may become contaminated by and acquire undesirable characteristics of others. These symptoms are found in patients with obsessive–compulsive disorder (OCD) and are thought to be related to mental contamination. Given the high levels of distress and interference morphing fears can cause, a reliable and valid assessment measure is needed. This article describes the development and evaluation of the Morphing Fear Questionnaire (MFQ), a 13‐item measure designed to assess for the presence and severity of morphing fears. A sample of 900 participants took part in the research. Of these, 140 reported having a current diagnosis of OCD (SR‐OCD) and 760 reported never having had OCD (N‐OCD; of whom 24 reported a diagnosis of an anxiety disorder and 23 reported a diagnosis of depression). Factor structure, reliability and construct and criterion‐related validity were investigated. Exploratory and confirmatory factor analyses supported a one‐factor structure replicable across the N‐OCD and SR‐OCD group. The MFQ was found to have high internal consistency and good temporal stability and showed significantly greater associations with convergent measures (assessing obsessive–compulsive symptoms, mental contamination, thought–action fusion and magical thinking) than with divergent measures (assessing depression and anxiety). Moreover, the MFQ successfully discriminated between the SR‐OCD sample and the N‐OCD group, anxiety disorder sample and depression sample. These findings suggest that the MFQ has sound psychometric properties and that it can be used to assess morphing fear. Clinical implications are discussed. Copyright © 2015 John Wiley & Sons, Ltd.Key Practitioner MessageLittle remains known about morphing fears, but it is an important area of investigation due to symptoms being highly distressing and often debilitatingBecause morphing fears commonly present as obscure symptoms, they may not be recognized as a type of OCDThe MFQ is a robust measure with clinical utility; it can facilitate recognition and assessment of morphing fearsThe MFQ will allow for further investigations of the prevalence, correlates and treatment outcomes of morphing fears.
Common Factors and Depressive Symptom Relief Trajectories in Group Teletherapy for Persons Ageing with HIV
Authors: Heckman Timothy G. , Heckman Bernadette Davantes , Anderson Timothy , Bianco Joseph A. , Sutton Mark , Lovejoy Travis I. 
Published: November 2015

Telepsychology research has focused primarily on treatment efficacy, with far less attention devoted to how common factors relate to teletherapy outcomes. This research identified trajectories of depressive symptom relief in 105 older people living with HIV with elevated depressive symptoms enrolled in a randomized clinical trial testing two 12‐session group teletherapies and compared common factors (e.g., therapeutic alliance and group cohesion) across depressive symptom trajectory groups. Growth mixture modelling of weekly depression scores identified three depressive symptom change groups: (1) ‘early improvers’ (31%) who reported reductions in depressive symptoms by Session 4; (2) ‘delayed improvers’ (16%) whose symptoms improved after Session 5 and (3) ‘non‐improvers’ (53%). Therapeutic alliance was unrelated to treatment outcome group. Group cohesion was greater in early improvers than non‐improvers. Group cohesion was unexpectedly lower, and group member similarity was greater in delayed improvers than non‐improvers. Early improvers had been living with HIV/AIDS for fewer years than non‐improvers. In group teletherapy, group cohesion and group member similarity are more important than client–therapist alliance. Copyright © 2015 John Wiley & Sons, Ltd.Key Practitioner Message

In group teletherapy with older people living with HIV (OPLWHIV), three latent outcome trajectory groups emerged over the 12‐week treatment period: (1) non‐improvers (53%); (2) early improvers (31%) and (3) delayed improvers (16%).
In group teletherapy with OPLWHIV, group cohesion is a stronger predictor of depressive symptom relief than is client–therapist alliance.
OPLWHIV in group teletherapy who do not respond to treatment until the latter therapy sessions can still experience depressive symptom relief comparable with early responders.
Improved performance‐based seismic assessment of buildings by utilizing Bayesian statistics
Authors: Esmaili Omid , Grant Ludwig Lisa , Zareian Farzin 
Published: November 2015

SummaryThis paper addresses two important issues of concern to practicing engineers and researchers alike in application of performance‐based seismic assessment (PBSA) methodology on buildings: (i) the number of ground motion records required to exercise PBSA—current practice (FEMA P‐58‐1) requires eleven or more pairs of motions for this purpose, and (ii) the time and effort associated with performing the number of nonlinear response history analyses required to exercise PBSA. We present a method for exercising of PBSA that employs classical linear modal analysis to develop a first estimate (i.e., a priori) of probability distribution of loss, followed by utilizing Bayesian statistics to update this estimate using estimates of loss obtained by utilizing a small number of nonlinear response history analyses of a detailed model of the building (i.e., posterior). The proposed technique is used to assess the distribution of monetary loss of two case studies, a 4‐story reinforced concrete moment‐resisting frame building and a 20‐story steel moment‐resisting frame building, both located in Los Angeles, for a ground motion hazard with 10% probability of exceedance in 50 years. The efficiency of the proposed PBSA method is demonstrated by showing the similarity between the distribution of monetary loss at each story of case study buildings obtained from the traditional/sophisticated PBSA methodology and the proposed PBSA method in this study. Copyright © 2015 John Wiley & Sons, Ltd.
Seismic hazard disaggregation in performance‐based earthquake engineering: occurrence or exceedance?
Authors: Fox Matthew J. , Stafford Peter J. , Sullivan Timothy J. 
Published: November 2015

SummarySeismic hazard disaggregation is commonly used as an aid in ground‐motion selection for the seismic response analysis of structures. This short communication investigates two different approaches to disaggregation related to the exceedance and occurrence of a particular intensity. The impact the different approaches might have on a subsequent structural analysis at a given intensity is explored through the calculation of conditional spectra. It is found that the exceedance approach results in conditional spectra that will be conservative when used as targets for ground‐motion selection. It is however argued that the use of the occurrence disaggregation is more consistent with the objectives of seismic response analyses in the context of performance‐based earthquake engineering. Copyright © 2015 John Wiley & Sons, Ltd.
An immersed interface method for flow past circular cylinder in the vicinity of a plane moving wall
Authors: Li Zhong , Jaiman Rajeev K. , Khoo Boo Cheong 
Published: November 2015

SummaryTwo‐dimensional flows past a stationary circular cylinder near a plane boundary are numerically simulated using an immersed interface method with second‐order accuracy. Instead of a fixed wall, a moving wall with no‐slip boundary is considered to avoid the complex involvement of the boundary layer and to focus only on the shear‐free wall proximity effects for investigating the force dynamics and flow fields. To analyze the convergence and accuracy of our implementation, numerical studies have been first performed on a simple test problem of rotational flow, where the second order of convergence is confirmed through numerical experiments and an optimal range of relative grid‐match ratio of Lagrangian to Eulerian grid sizes has been recommended. By comparing the force quantities and the Strouhal number, the accuracy of this method has been demonstrated on the flow past a stationary isolated cylinder. The cylinder is then put in proximity to the wall to investigate the shear‐free wall proximity effects in the low Reynolds number regime (20≤Re≤200). The gap ratio,e/D, whereedenotes the gap between the cylinder and the moving wall andDdenotes the diameter of the cylinder, is taken from 0.10 to 2.00 to determine the critical gap ratio, (e/D)critical, for the alternate vortex shedding, where the fluid forces, flow fields and the streamwise velocity profiles are studied. One of the key findings is that the (e/D)criticalfor the alternate vortex shedding decreases as the Reynolds number increases. We also find that, in this low Reynolds number regime, the mean drag coefficient increases and peaks ate/D= 0.5 with the increase ofe/Dand keeps decreasing gently frome/D= 0.5 toe/D= 2.0, while the mean lift coefficient decreases monotonically with the increase ofe/D. New correlations are then proposed for computing force coefficients as a function ofReande/Dfor a cylinder in the vicinity of a moving plane wall. Copyright © 2015 John Wiley & Sons, Ltd.
A data‐driven approach to mapping cortical and subcortical intrinsic functional connectivity along the longitudinal hippocampal axis
Authors: Blessing Esther M. , Beissner Florian , Schumann Andy , Brünner Franziska , Bär Karl‐Jürgen 
Published: November 2015

AbstractThe hippocampus (HPC) is functionally heterogeneous along the longitudinal anterior–posterior axis. In rodent models, gene expression maps define at least three discrete longitudinal subregions, which also differ in function, and in anatomical connectivity with the rest of the brain. In humans, equivalent HPC subregions are less well defined, resulting in a lack of consensus in neuroimaging approaches that limits translational study. This study determined whether a data‐driven analysis, namely independent component analysis (ICA), could reproducibly define human HPC subregions, and map their respective intrinsic functional connectivity (iFC) with the rest of the brain. Specifically, we performed ICA of resting‐state fMRI activity spatially restricted within the HPC, to determine the configuration and reproducibility of functional HPC components. Using dual regression, we then performed multivariate analysis of iFC between resulting HPC components and the whole brain, including detailed connectivity with the hypothalamus, a functionally important connection not yet characterized in human. We found hippocampal ICA resulted in highly reproducible longitudinally discrete components, with greater functional heterogeneity in the anterior HPC, consistent with animal models. Anterior hippocampal components shared iFC with the amygdala, nucleus accumbens, medial prefrontal cortex, posterior cingulate cortex, midline thalamus, and periventricular hypothalamus, whereas posterior hippocampal components shared iFC with the anterior cingulate cortex, retrosplenial cortex, and mammillary bodies. We show that spatially masked hippocampal ICA with dual regression reproducibly identifies functional subregions in the human HPC, and maps their respective brain intrinsic connectivity. Hum Brain Mapp 37:462–476, 2016. © 2015 Wiley Periodicals, Inc.
Large‐scale phenotyping links adult hippocampal neurogenesis to the reaction to novelty
Authors: van Dijk R. Maarten , Lazic Stanley E. , Slomianka Lutz , Wolfer David P. , Amrein Irmgard 
Published: November 2015

ABSTRACTThe discovery of adult‐born neurons in the hippocampus has triggered a wide range of studies that link the new neurons to various behavioral functions. However, the role of new neurons in behavior is still equivocal. Conflicting results may be due to the difficulty in manipulating neurogenesis without off‐target effects as well as the statistical approach used, which fail to account for neurogenesis‐independent effects of experimental manipulations on behavior. In this study, we apply a more comprehensive statistical and conceptual approach. Instead of between‐group analyses, we consider the within‐group relationships between neurogenesis and behavior (ANCOVA and mediation analysis) in a large‐scale experiment, in which distinct age‐ (3 and 5 months) and strain‐ (DBA and C57) related differences in basal levels of neurogenesis in mice are compared with a large number (∼1,500) of behavioral read outs. The analysis failed to detect any association between anxiety and motor impulsivity with neurogenesis. However, within‐group adult hippocampal neurogenesis is associated with the reaction to novelty. Specifically, more neurogenesis is associated with a longer latency to explore and a lower frequency of exploratory actions, overall indicative of a phenotype where animals with more neurogenesis were slower to explore a novel environment. This effect is observed in 5‐months‐old, but not in 3‐months‐old mice of both strains. An association between the reaction to novelty and adult neurogenesis can have a major impact on results from previous studies using classical behavioral experiments, in which animals are tested in a—for the animal—novel experimental set‐up. The neurogenesis–novelty association found here is also a necessary link in the relation that has been suggested to exist between neurogenesis and psychiatric disorders marked by a failure to cope with novelty. © 2015 Wiley Periodicals, Inc.
Well‐Balanced Designs for Data Placement
Authors: Bermond Jean‐Claude , Jean‐Marie Alain , Mazauric Dorian , Yu Joseph 
Published: November 2015

AbstractThe problem we consider in this article is motivated by data placement, in particular data replication in distributed storage and retrieval systems. We are given a set V of v servers along with b files (data, documents). Each file is replicated on exactly k servers. A placement consists in finding a family of b subsets of V (representing the files) called blocks, each of size k. Each server has some probability to fail and we want to find a placement that minimizes the variance of the number of available files. It was conjectured that there always exists an optimal placement (with variance better than any other placement for any value of the probability of failure). We show that the conjecture is true, if there exists a well‐balanced design—that is, a family of blocks—each of size k, such that each j‐element subset of V, , belongs to the same or almost the same number of blocks (difference at most one). The existence of well‐balanced designs is a difficult problem as it contains, as a subproblem, the existence of Steiner systems. We completely solve the case and give bounds and constructions for and some values of v and b.
An empirical examination of personal learning within the context of teams
Authors: Jiang Yuan , Jackson Susan E. , Colakoglu Saba 
Published: November 2015

SummaryUsing a sample of 588 employees in 59 work teams, we tested a model that situates personal learning within the context of teams, viewing it as a joint function of teams' leadership climate (i.e., transformational leadership) and task characteristics (i.e., task routineness and task interdependence). Consistent with our hypotheses, we found that the positive relationships between transformational leadership climate and the two dimensions of personal learning (relational job learning and personal skill development) were moderated by the nature of the teams' tasks. Specifically, transformational leadership climate was more strongly associated with personal learning for members of teams working on tasks that were less routine, rather than more routine. However, no significant moderation was found for leadership climate and task interdependence. Our findings underscore the importance of taking into account the contextual conditions within which leadership influence occurs while also demonstrating the potential role that leaders can play in promoting employees' personal learning. Overall, our study bolsters theories that conceptualize adult learning as a transaction between people and their social environments and points to a practical need to match leadership styles with team task characteristics to unleash transformational leadership effects. Copyright © 2015 John Wiley & Sons, Ltd.