bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oxidative phosphorylation-dependent regulation of cancer cell apoptosis in response to anticancer agents
Authors: Yadav N , Kumar S , Marlowe T , Chaudhary A K , Kumar R , Wang J , O'Malley J , Boland P M , Jayanthi S , Kumar T K S , Yadava N , Chandra D 
Published: November 2015

AbstractCancer cells tend to develop resistance to various types of anticancer agents, whether they adopt similar or distinct mechanisms to evade cell death in response to a broad spectrum of cancer therapeutics is not fully defined. Current study concludes that DNA-damaging agents (etoposide and doxorubicin), ER stressor (thapsigargin), and histone deacetylase inhibitor (apicidin) target oxidative phosphorylation (OXPHOS) for apoptosis induction, whereas other anticancer agents including staurosporine, taxol, and sorafenib induce apoptosis in an OXPHOS-independent manner. DNA-damaging agents promoted mitochondrial biogenesis accompanied by increased accumulation of cellular and mitochondrial ROS, mitochondrial protein-folding machinery, and mitochondrial unfolded protein response. Induction of mitochondrial biogenesis occurred in a caspase activation-independent mechanism but was reduced by autophagy inhibition and p53-deficiency. Abrogation of complex-I blocked DNA-damage-induced caspase activation and apoptosis, whereas inhibition of complex-II or a combined deficiency of OXPHOS complexes I, III, IV, and V due to impaired mitochondrial protein synthesis did not modulate caspase activity. Mechanistic analysis revealed that inhibition of caspase activation in response to anticancer agents associates with decreased release of mitochondrial cytochrome c in complex-I-deficient cells compared with wild type (WT) cells. Gross OXPHOS deficiencies promoted increased release of apoptosis-inducing factor from mitochondria compared with WT or complex-I-deficient cells, suggesting that cells harboring defective OXPHOS trigger caspase-dependent as well as caspase-independent apoptosis in response to anticancer agents. Interestingly, DNA-damaging agent doxorubicin showed strong binding to mitochondria, which was disrupted by complex-I-deficiency but not by complex-II-deficiency. Thapsigargin-induced caspase activation was reduced upon abrogation of complex-I or gross OXPHOS deficiency whereas a reverse trend was observed with apicidin. Together, these finding provide a new strategy for differential mitochondrial targeting in cancer therapy.
Spectral splitting photovoltaics using perovskite and wideband dye-sensitized solar cells
Authors: Kinoshita Takumi , Nonomura Kazuteru , Joong Jeon Nam , Giordano Fabrizio , Abate Antonio , Uchida Satoshi , Kubo Takaya , Seok Sang Il , Nazeeruddin Mohammad Khaja , Hagfeldt Anders , Grätzel Michael , Segawa Hiroshi 
Published: November 2015

AbstractThe extension of the light absorption of photovoltaics into the near-infrared region is important to increase the energy conversion efficiency. Although the progress of the lead halide perovskite solar cells is remarkable, and high conversion efficiency of >20% has been reached, their absorption limit on the long-wavelength side is ∼800 nm. To further enhance the conversion efficiency of perovskite-based photovoltaics, a hybridized system with near-infrared photovoltaics is a useful approach. Here we report a panchromatic sensitizer, coded DX3, that exhibits a broad response into the near-infrared, up to ∼1100 nm, and a photocurrent density exceeding 30 mA cm−2 in simulated air mass 1.5 standard solar radiation. Using the DX3-based dye-sensitized solar cell in conjunction with a perovskite cell that harvests visible light, the hybridized mesoscopic photovoltaics achieved a conversion efficiency of 21.5% using a system of spectral splitting.
Inward lithium-ion breathing of hierarchically porous silicon anodes
Authors: Xiao Qiangfeng , Gu Meng , Yang Hui , Li Bing , Zhang Cunman , Liu Yang , Liu Fang , Dai Fang , Yang Li , Liu Zhongyi , Xiao Xingcheng , Liu Gao , Zhao Peng , Zhang Sulin , Wang Chongmin , Lu Yunfeng , Cai Mei 
Published: November 2015

AbstractSilicon has been identified as a highly promising anode for next-generation lithium-ion batteries (LIBs). The key challenge for Si anodes is large volume change during the lithiation/delithiation cycle that results in chemomechanical degradation and subsequent rapid capacity fading. Here we report a novel fabrication method for hierarchically porous Si nanospheres (hp-SiNSs), which consist of a porous shell and a hollow core. On charge/discharge cycling, the hp-SiNSs accommodate the volume change through reversible inward Li breathing with negligible particle-level outward expansion. Our mechanics analysis revealed that such inward expansion is enabled by the much stiffer lithiated layer than the unlithiated porous layer. LIBs assembled with the hp-SiNSs exhibit high capacity, high power and long cycle life, which is superior to the current commercial Si-based anode materials. The low-cost synthesis approach provides a new avenue for the rational design of hierarchically porous structures with unique materials properties.
Features of COPD patients by comparing CAT with mMRC: a retrospective, cross-sectional study
Authors: Huang Wei-Chang , Wu Ming-Feng , Chen Hui-Chen , Hsu Jeng-Yuan ,   The TOLD study group
Published: November 2015

Abstract
Background:
The group assignment of chronic obstructive pulmonary disease (COPD) may differ depending on whether the COPD assessment test (CAT) or modified Medical Research Council dyspnoea scale (mMRC) is used.

Aims:
This study intended to clarify how different patient characteristics influence the differences, to determine the relationships between CAT and mMRC and to characterise COPD patients by both CAT and mMRC.

Methods:
This was a retrospective, cross-sectional study. The data, collected by Taiwan Obstructive Lung Disease consortium, were managed and analysed.

Results:
Of the 757 participants, COPD group assignment was not identical as well as no substantial agreement presented when categorised based on the cut-point CAT score ⩾10 and each mMRC cut-point. In all, 38.2% of participants had discordant group assignments together with a lower mean CAT score, less severe airway obstruction and less severe airflow limitation compared with those with concordant group assignments. In the discordant group, the CAT⩾10/mMRC 0–1 subgroup had more wheezing than CAT<10/mMRC⩾2 subgroup. Only moderate correlations existed between CAT and mMRC. More-symptom groups and combined high-risk group had better correlations than less-symptom groups and combined low-risk group, respectively. A modest negative correlation existed between forced expiratory volume in 1 s percentage (FEV1%) predicted and CAT score and between FEV1% predicted and mMRC scale in parallel with a significant positive relationship existing between the CAT score and mMRC scale. Notably, a significant proportion of COPD patients with each scale of mMRC had health status impairment.

Conclusions:
The Global initiative for Chronic Obstructive Lung Disease committee should redefine the applications of CAT and mMRC in the management of COPD.
The Frenkel Line: a direct experimental evidence for the new thermodynamic boundary
Authors: Bolmatov Dima , Zhernenkov Mikhail , Zav’yalov Dmitry , Tkachev Sergey N. , Cunsolo Alessandro , Cai Yong Q. 
Published: November 2015

AbstractSupercritical fluids play a significant role in elucidating fundamental aspects of liquid matter under extreme conditions. They have been extensively studied at pressures and temperatures relevant to various industrial applications. However, much less is known about the structural behaviour of supercritical fluids and no structural crossovers have been observed in static compression experiments in any temperature and pressure ranges beyond the critical point. The structure of supercritical state is currently perceived to be uniform everywhere on the pressure-temperature phase diagram and to change only in a monotonic way even moving around the critical point, not only along isotherms or isobars. Conversely, we observe structural crossovers for the first time in a deeply supercritical sample through diffraction measurements in a diamond anvil cell and discover a new thermodynamic boundary on the pressure-temperature diagram. We explain the existence of these crossovers in the framework of the phonon theory of liquids using molecular dynamics simulations. The obtained results are of prime importance since they imply a global reconsideration of the mere essence of the supercritical phase. Furthermore, this discovery may pave the way to new unexpected applications and to the exploration of exotic behaviour of confined fluids relevant to geo- and planetary sciences.
Ultra-flexible Piezoelectric Devices Integrated with Heart to Harvest the Biomechanical Energy
Authors: Lu Bingwei , Chen Ying , Ou Dapeng , Chen Hang , Diao Liwei , Zhang Wei , Zheng Jun , Ma Weiguo , Sun Lizhong , Feng Xue 
Published: November 2015

AbstractPower supply for medical implantable devices (i.e. pacemaker) always challenges not only the surgery but also the battery technology. Here, we report a strategy for energy harvesting from the heart motion by using ultra-flexible piezoelectric device based on lead zirconate titanate (PZT) ceramics that has most excellent piezoelectricity in commercial materials, without any burden or damage to hearts. Experimental swine are selected for in vivo test with different settings, i.e. opened chest, close chest and awake from anesthesia, to simulate the scenario of application in body due to their hearts similar to human. The results show the peak-to-peak voltage can reach as high as 3 V when the ultra-flexible piezoelectric device is fixed from left ventricular apex to right ventricle. This demonstrates the possibility and feasibility of fully using the biomechanical energy from heart motion in human body for sustainably driving implantable devices.
Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients
Authors: Liu Wei , Ling Shukuan , Sun Weijia , Liu Tong , Li Yuheng , Zhong Guohui , Zhao Dingsheng , Zhang Pengfei , Song Jinping , Jin Xiaoyan , Xu Zi , Song Hailin , Li Qi , Liu Shujuan , Chai Meng , Dai Qinyi , He Yi , Fan Zhanming , Zhou Yu Jie , Li Yingxian 
Published: November 2015

AbstractThe purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC) and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary artery disease (CAD) were characterized with coronary artery calcium score (CACS) from cardiac computed tomography (CT). We analyzed plasma miRNA levels of clinical matched 11 CAC (CACS > 100) and 6 non-CAC (CACS = 0) subjects by microarray profile. Microarray analysis identified 34 differentially expressed miRNAs between CAC and non CAC groups. Eight miRNAs (miR-223, miR-3135b, miR-133a-3p, miR-2861, miR-134, miR-191-3p, miR-3679-5p, miR-1229 in CAC patients) were significantly increased in CAC plasma in an independent clinical matched cohort. Four miRNAs (miR-2861, 134, 1229 and 3135b) were correlated with the degree of CAC. Validation test in angiographic cohort showed that miR-134, miR-3135b and miR-2861 were significantly changed in patients with obstructive CAD . We identified three significantly upregulated circulating miRNAs (miR-134, miR-3135b and 2861) correlated with CAC while detected obstructive coronary disease in symptomatic patients.
Wnt/β-catenin coupled with HIF-1α/VEGF signaling pathways involved in galangin neurovascular unit protection from focal cerebral ischemia
Authors: Wu Chuanhong , Chen Jianxin , Chen Chang , Wang Wei , Wen Limei , Gao Kuo , Chen Xiuping , Xiong Sihuai , Zhao Huihui , Li Shaojing 
Published: November 2015

AbstractMicroenvironmental regulation has become a promising strategy for complex disease treatment. The neurovascular unit (NVU), as the key structural basis to maintain an optimal brain microenvironment, has emerged as a new paradigm to understand the pathology of stroke. In this study, we investigated the effects of galangin, a natural flavonoid isolated from the rhizome of Alpina officinarum Hance, on NVU microenvironment improvement and associated signal pathways in rats impaired by middle cerebral artery occlusion (MCAO). Galangin ameliorated neurological scores, cerebral infarct volume and cerebral edema and reduced the concentration of Evans blue (EB) in brain tissue. NVU ultrastructural changes were also improved by galangin. RT-PCR and western blot revealed that galangin protected NVUs through the Wnt/β-catenin pathway coupled with HIF-1α and vascular endothelial growth factor (VEGF). VEGF and β-catenin could be the key nodes of these two coupled pathways. In conclusion, Galangin might function as an anti-ischemic stroke drug by improving the microenvironment of NVUs.
Stabilization of magnetic helix in exchange-coupled thin films
Authors: Dzemiantsova L. V. , Meier G. , Röhlsberger R. 
Published: November 2015

AbstractBased on micromagnetic simulations, we report on a novel magnetic helix in a soft magnetic film that is sandwiched between and exchange-coupled to two hard magnetic layers with different anisotropies. We show that such a confined helix stays stable without the presence of an external magnetic field. The magnetic stability is determined by the energy minimization and is a result of an internal magnetic field created by the exchange interaction. We show that this internal field stores a magnetic energy density of a few kJ/m3. We also find that it dramatically modifies ferromagnetic resonances, such that the helix can be used as a ferromagnetic resonance filter and a fast acting attenuator.
Platinized Graphene/ceramics Nano-sandwiched Architectures and Electrodes with Outstanding Performance for PEM Fuel Cells
Authors: Chen Xu , He Daping , Wu Hui , Zhao Xiaofeng , Zhang Jian , Cheng Kun , Wu Peng , Mu Shichun 
Published: November 2015

AbstractFor the first time a novel oxygen reduction catalyst with a 3D platinized graphene/nano-ceramic sandwiched architecture is successfully prepared by an unusual method. Herein the specific gravity of graphene nanosheets (GNS) is tailored by platinizing graphene in advance to shorten the difference in the specific gravity between carbon and SiC materials and then nano-SiC is well intercalated into GNS interlayers. This nano-architecture with highly dispersed Pt nanoparticles exhibits a very high oxygen reduction reaction (ORR) activity and polymer electrolyte membrane (PEM) fuel cell performance. The mass activity of half cells is 1.6 times of that of the GNS supported Pt and 2.4 times that of the commercial Pt/C catalyst, respectively. Moreover, after an accelerated stress test our catalyst shows a predominantly electrochemical stability compared with benchmarks. Further fuel cell tests show a maximum power density as high as 747 mW/cm2 at low Pt loading, which is more than 2 times higher than that of fuel cells with the pristine graphene electrode.
Versatile Molding Process for Tough Cellulose Hydrogel Materials
Authors: Kimura Mutsumi , Shinohara Yoshie , Takizawa Junko , Ren Sixiao , Sagisaka Kento , Lin Yudeng , Hattori Yoshiyuki , Hinestroza Juan P. 
Published: November 2015

AbstractShape-persistent and tough cellulose hydrogels were fabricated by a stepwise solvent exchange from a homogeneous ionic liquid solution of cellulose exposure to methanol vapor. The cellulose hydrogels maintain their shapes under changing temperature, pH and solvents. The micrometer-scale patterns on the mold were precisely transferred onto the surface of cellulose hydrogels. We also succeeded in the spinning of cellulose hydrogel fibers through a dry jet-wet spinning process. The mechanical property of regenerated cellulose fibers improved by the drawing of cellulose hydrogel fibers during the spinning process. This approach for the fabrication of tough cellulose hydrogels is a major advance in the fabrication of cellulose-based structures with defined shapes.
The Influence of Phonotactic Probability on Nonword Repetition and Fast Mapping in 3-Year-Olds With a History of Expressive Language Delay
Authors: MacRoy-Higgins Michelle , Dalton Kevin Patrick 
Published: November 2015

Purpose
The purpose of this study was to examine the influence of phonotactic probability on sublexical (phonological) and lexical representations in 3-year-olds who had a history of being late talkers in comparison with their peers with typical language development.

Method
Ten 3-year-olds who were late talkers and 10 age-matched typically developing controls completed nonword repetition and fast mapping tasks; stimuli for both experimental procedures differed in phonotactic probability.

Results
Both participant groups repeated nonwords containing high phonotactic probability sequences more accurately than nonwords containing low phonotactic probability sequences. Participants with typical language showed an early advantage for fast mapping high phonotactic probability words; children who were late talkers required more exposures to the novel words to show the same advantage for fast mapping high phonotactic probability words.

Conclusions
Children who were late talkers showed similar sensitivities to phonotactic probability in nonword repetition and word learning when compared with their peers with no history of language delay. However, word learning in children who were late talkers appeared to be slower when compared with their peers.
The Effects of Age and Preoral Sensorimotor Cues on Anticipatory Mouth Movement During Swallowing
Authors: Shune Samantha E. , Moon Jerald B. , Goodman Shawn S. 
Published: November 2015

Purpose
The aim of this study was to investigate the effects of preoral sensorimotor cues on anticipatory swallowing/eating-related mouth movements in older and younger adults. It was hypothesized that these cues are essential to timing anticipatory oral motor patterns, and these movements are delayed in older as compared with younger adults.

Method
Using a 2 × 2 repeated-measures design, eating-related lip, jaw, and hand movements were recorded from 24 healthy older (ages 70–85 years) and 24 healthy younger (ages 18–30 years) adults under 4 conditions: typical self-feeding, typical assisted feeding (proprioceptive loss), sensory-loss self-feeding (auditory and visual loss/degradation), and sensory-loss assisted feeding (loss/degradation of all cues).

Results
All participants demonstrated anticipatory mouth opening. The absence of proprioception delayed lip-lowering onset, and sensory loss more negatively affected offset. Given at least 1 preoral sensorimotor cue, older adults initiated movement earlier than younger adults.

Conclusions
Preoral sensorimotor information influences anticipatory swallowing/eating-related mouth movements, highlighting the importance of these cues. Earlier movement in older adults may be a compensation, facilitating safe swallowing given other age-related declines. Further research is needed to determine if the negative impact of cue removal may be further exacerbated in a nonhealthy system (e.g., presence of dysphagia or disease), potentially increasing swallowing- and eating-related risks.
Evaluating disease similarity using latent Dirichlet allocation
Authors: Frick James , Guha Rajarshi , Peryea Tyler , Southall Noel T. 
Published: November 2015

AbstractMeasures of similarity between diseases have been used for applications from discovering drug-target interactions to identifying disease-gene relationships. It is challenging to quantitatively compare diseases because much of what we know about them is captured in free text descriptions. Here we present an application of Latent Dirichlet Allocation as a way to measure similarity between diseases using textual descriptions. We learn latent topic representations of text from Online Mendelian Inheritance in Man records and use them to compute similarity. We assess the performance of this approach by comparing our results to manually curated relationships from the Disease Ontology. Despite being unsupervised, our model recovers a record’s curated Disease Ontology relations with a mean Receiver Operating Characteristic Area Under the Curve of 0.80. With low dimensional models, topics tend to represent higher level information about affected organ systems, while higher dimensional models capture more granular genetic and phenotypic information. We examine topic representations of diseases for mapping concepts between ontologies and for tagging existing text with concepts. We conclude topic modeling on disease text leads to a robust approach to computing similarity that does not depend on keywords or ontology.
An evaluation of post-production facial composite enhancement techniques
Authors: Davis Josh P , Simmons Stacie , Sulley Lucy , Solomon Chris , Gibson Stuart 
Published: November 2015

Purpose– The purpose of this paper is to describe four experiments evaluating post-production enhancement techniques with facial composites mainly created using the EFIT-V holistic system.Design/methodology/approach– Experiments 1-4 were conducted in two stages. In Stage 1, constructors created between one and four individual composites of unfamiliar targets. These were merged to create morphs. Additionally in Experiment 3, composites were vertically stretched. In Stage 2, participants familiar with the targets named or provided target-similarity ratings to the images.Findings– In Experiments 1-3, correct naming rates were significantly higher to between-witness 4-morphs, within-witness 4-morphs and vertically stretched composites than to individual composites. In Experiment 4, there was a positive relationship between composite-target similarity ratings and between-witness morph-size (2-, 4-, 8-, 16-morphs).Practical implications– The likelihood of a facial composite being recognised can be improved by morphing and vertical stretch.Originality/value– This paper improves knowledge of the theoretical underpinnings of these facial composite post-production enhancement techniques. This should encourage acceptance by the criminal justice system, and lead to better detection outcomes.
A sustainable urban logistics dashboard from the perspective of a group of operational managers
Authors: Morana Joëlle , Gonzalez-Feliu Jesus 
Published: November 2015

Purpose– The purpose of this paper is to propose a sustainable dashboard for evaluating the sustainable performance of urban delivery systems from the perspective of operational logistics managers, one of the categories of stakeholders given less consideration by public authorities in their quest for consensus.Design/methodology/approach– First, a synthesis of the main works on the subject is proposed to provide a common grid of economic, environmental and social/societal indicators for sustainable supply chain management (SSCM), after which the method for defining the dashboard is presented. This method is derived from a collaborative decision-support approach and applied to a panel of operational logistics managers. Using a co-constructive method, a group of experts is consulted first separately, then by small groups and then a group restitution and consensus search process is made to find an agreed-upon set of indicators.Findings– The results show a difference between the indicators chosen in the individual phase and those defined in small groups. They also show a gap between classical expert-obtained indicators (mainly made by one or a small group of non-operational experts) and the proposed dashboard, made by and for operational managers.Originality/value– The originality of the paper is that it addresses two issues (urban logistics evaluation and consensus search) by using methods of natural and active pedagogy and shows by an experimental method the interests and opportunities of collaboration in defining sets of indicators for urban logistics evaluation.