bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hot air–assisted radio frequency drying of orange slices: Drying behavior and product quality
Authors: Ismail Mohammed , Özbek Hatice Neval , Göğüş Fahrettin 
Published: August 2024

AbstractThis research aimed to assess the hot air–assisted radio frequency drying (HA‐RFD) of orange slices to evaluate the possibility of producing high‐quality dried orange slices and overcome the problem of the long drying time and the high energy consumption. The effect of electrode distance (60, 70, and 80 mm) and number of slices (1–3 slices; 4 mm thickness per slice) on the HA‐RFD of orange slices was evaluated. Orange slices in three layers with a total thickness of 12 mm and an electrode gap of 70 mm were picked to dry the orange slices in the shortest time. The quality of orange slices dried with HA‐RFD was compared with those of HA‐dried (HAD) and freeze‐dried (FD) samples. HA‐RFD allowed a 67% decrease in the time of drying of the orange slices (from 1170 to 390 min) when compared to HAD. Total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity, and color values were affected by the drying technique. HA‐RFD showed higher TPC, TFC, and antioxidant activity than HAD. The FD samples showed the highest TPC (928 mg GAE/100 g dw), TFC (200 mg rutin/100 g dw), and antioxidant activity (67.58%). Moreover, the samples dried with HA‐RFD resulted in the least color change in comparison to HAD and FD samples. Regarding vitamin C, FD samples were the best, followed by HA‐RFD and HAD, respectively. Considering the final product quality, and the characteristics of drying techniques, especially drying time and drying rate, HA‐RFD proved to be an alternative technique to the HAD for producing dried orange slices.Practical ApplicationHA‐RFD was applied for the first time as an alternative technology to dry orange slices. The quality of orange samples dried by HA‐RFD was compared with samples that dried by HAD and FD. The results indicated that the HA‐RFD technique is a good method to dry orange slices by considering the drying characteristics and the final product quality.
Nursing diagnoses related to cardiovascular function in primary care: A scoping review
Authors: Cruz Neto João , de Oliveira Lopes Marcos Venícios 
Published: August 2024

AbstractObjectiveTo map nursing diagnoses related to cardiovascular function reported in studies involving patients in primary care.MethodA scoping review follows JBI guidelines. Literature searches were conducted from March to May 2024. Studies included focused on nursing diagnoses for adults and older adult patients with cardiovascular conditions in primary care settings. Results were systematically presented in tables and narratively.FindingsAmong the 12 included studies, the most prevalent diagnosis was “noncompliance” (00079), removed from NANDA‐I in 2017. Sixteen other diagnoses were identified, indicating a broader clinical profile of individuals with cardiovascular health issues in primary care. Most studies involved patients with hypertension in Brazil.ConclusionsKey nursing diagnoses for patients with cardiovascular conditions in primary care were identified. Ineffective health management emerged as a common characteristic among this population.Implications for nursing practiceIdentifying prevalent diagnoses allows nurses to reinforce their commitment to managing cardiovascular conditions, improve care plans, and generate practice indicators for services, thus enhancing the quality of care provided.
Tretinoin synergistically enhances the antitumor effect of combined BRAF, MEK, and EGFR inhibition in BRAFV600E colorectal cancer
Authors: Yoshida Yuya , Takahashi Masanobu , Taniguchi Sakura , Numakura Ryunosuke , Komine Keigo , Ishioka Chikashi 
Published: August 2024

AbstractPatients with BRAF‐mutated colorectal cancer (BRAFV600E CRC) are currently treated with a combination of BRAF inhibitor and anti‐EGFR antibody with or without MEK inhibitor. A fundamental problem in treating patients with BRAFV600E CRC is intrinsic and/or acquired resistance to this combination therapy. By screening 78 compounds, we identified tretinoin, a retinoid, as a compound that synergistically enhances the antiproliferative effect of a combination of BRAF inhibition and MEK inhibition with or without EGFR inhibition on BRAFV600E CRC cells. This synergistic effect was also exerted by other retinoids. Tretinoin, added to BRAF inhibitor and MEK inhibitor, upregulated PARP, BAK, and p‐H2AX. When either RARα or RXRα was silenced, the increase in cleaved PARP expression by the addition of TRE to ENC/BIN or ENC/BIN/CET was canceled. Our results suggest that the mechanism of the synergistic antiproliferative effect involves modulation of the Bcl‐2 family and the DNA damage response that affects apoptotic pathways, and this synergistic effect is induced by RARα‐ or RXRα‐mediated apoptosis. Tretinoin also enhanced the antitumor effect of a combination of the BRAF inhibitor and anti‐EGFR antibody with or without MEK inhibitor in a BRAFV600E CRC xenograft mouse model. Our data provide a rationale for developing retinoids as a new combination agent to overcome resistance to the combination therapy for patients with BRAFV600E CRC.
Alantolactone facilitates ferroptosis in non‐small cell lung cancer through promoting FTH1 ubiquitination and degradation
Authors: Huang Yijiao , Xiang Pei , Chen Yuanyuan , Pan Qi , Yuan Kemiao 
Published: August 2024

AbstractAlantolactone (ALT), a natural sesquiterpene lactone from Inula helenium L., demonstrates potent antitumor activity in various human cancers, notably non‐small cell lung cancer (NSCLC). Despite its recognized efficacy, the precise mechanisms of action remain elusive. Our study aimed to elucidate ALT's impact on NSCLC. Our findings suggested that ALT triggered apoptosis both in vitro and in vivo, underscoring its anticancer potential. Interestingly, the ferroptosis inhibitor (Fer‐1), rather than necrostatin‐1 (Nec‐1) or Z‐VAD‐FMK, rescued ALT‐induced cell death, implicating ferroptosis as pivotal. Subsequent analyses revealed ferroptosis as the primary mechanism underlying ALT‐induced NSCLC cell death, supported by markers including ROS accumulation, MDA elevation, GSH depletion, Fe2+ generation, and GPX4 reduction. Through DARTS/MS proteomics, we identified FTH1 as the target of ALT‐induced ferroptosis. Immunoblotting confirmed ALT's inhibition of FTH1 protein expression and accelerated its degradation in NSCLC cells. Immunoprecipitation assays demonstrated increased FTH1 ubiquitination induced by ALT. Additionally, ALT induced ferroptosis and facilitated Fe2+ accumulation via FTH1 ubiquitination. Importantly, ALT displayed potent antitumor effects in a subcutaneous xenograft model in BALB/c‐nu/nu nude mice by enhancing ferroptosis. In summary, ALT induced ferroptosis by promoting intracellular Fe2+ accumulation through accelerated FTH1 degradation, highlighting its potential as an antitumor agent targeting ferroptosis.
‘Devoted Despite It All’: Norwegian Child Welfare Workers' Experiences of Implementing a Therapeutic Model for Adolescents With Co‐Occurring Problems
Authors: Kvamme Line Solheim , Waaler Pamela M. , Helland Siri Saugestad , Mellblom Anneli Viktoria , Ness Ottar 
Published: August 2024

ABSTRACTIn Norway, child welfare responsibilities are divided between state‐run (SCW) and municipal (MCW) agencies. This study explores MCW practitioners' experiences of implementing a therapeutic model tailored by SCW for MCW to aid adolescents with severe and co‐occurring problems and their families. In this qualitative study, 12 MCW practitioners participated in semistructured interviews about the implementability of the therapeutic model. The interviews were transcribed verbatim and analysed using reflexive thematic analysis. The codebook approach Framework Analysis was used to develop codes, initial themes and final themes through several iterations. Each theme was reviewed for convergence and divergence, across interviews. Practitioners' responses to the Intervention Usability Scale were used to supplement our analysis. Five themes emerged as follows: (1) Internal Motivation: practitioners were driven by the desire to do good; (2) Finally, We Have Something to Offer: highlighting the importance of methods that meet diverse needs; (3) Expectations and Entanglements: describing challenging incongruencies between implementors, practitioners and agencies; (4) Working Methodically: the significance of rigorous CW practices; and (5) Lost in Translation: implementation challenges language, culture and profession. Tailoring practices to resource‐limited communities is commendable but requires strengthening inter‐ and intra‐agency collaboration. Adopting novel practices in MCW settings requires professional implementors.
Modification of McGill Oximetry Score in Improving the Diagnostic Capability of Paediatric OSA
Authors: Wong Wannitta E. Ting , Saniasiaya Jeyasakthy , Salehuddin Nur Syazwani Mohd , H'ng Shih Ying , Nathan Anna Marie 
Published: August 2024

ABSTRACTObjectivesThis study aimed to devise a modified oximetry scoring system and calculate its diagnostic accuracy in detecting paediatric obstructive sleep apnoea syndrome (OSAS).Study DesignThis prospective diagnostic accuracy study was divided into two phases.SettingThe study was conducted at a quaternary teaching hospital.MethodsPolysomnograms performed from 1 April 2014 to 31 December 2021 were included. In Phase 1, the parameters of 95 oximetry trend graphs were evaluated, and a modified scoring system was constructed. In Phase 2, the modified scoring system was employed in 272 oximetry trend graphs, and its diagnostic accuracy was determined. A logistic regression model was used to assess the ability of each scoring system to predict paediatric OSAS.ResultsA total of 367 patients were recruited. In Phase 1, a four‐tier severity classification system was constructed. In Phase 2, its diagnostic accuracy was found to be 53.3% sensitive, 97% specific, with positive predictive value of 98.5% and negative predictive value of 34.6%. The lowest detectable apnoea–hypopnoea index (AHI) was 4.5. The inter‐rater reliability calculated was 80%. Logistic regression was applied to assess associations of the modified McGill score (MMS) or McGill oximetry score (MOS) with OSAS. The area under the receiver operating characteristic curve was higher for the MMS than for MOS (0.78 [95% CI 0.73–0.84] vs. 0.59 [95% CI 0.51–0.66]).ConclusionThis study demonstrated that our modified scoring system had increased sensitivity at detecting OSAS at a much lower AHI and showed a much greater ability to predict paediatric OSAS.
Transcendent emotions: A comparative study of Martin Luther's pietas and Zhu Xi's Cheng‐Jing
Authors: Jun Zhang 
Published: August 2024

AbstractBoth Martin Luther's pietas and Zhu Xi's Cheng‐Jing are not purely empirical emotional categories, but transcendent emotional categories of faith. By comparing Luther's pietas and Zhu Xi's Cheng‐Jing, this article reveals how Christianity and Confucianism constructed individual emotional and spiritual transcendence in early modernity. By doing so, it highlights both similarities and fundamental differences between Neo‐Confucianism and Protestantism in matters of faith, thus revealing their significance for modern society.
Royal Geographical Society (with IBG) Medals and Awards celebration 2024
Authors: Clifford Nigel , Lawrence Vanessa , Venables Stephen , Kong Lily , Clark Chris , McCarron Leon , Doerr Stefan 
Published: August 2024

AbstractThe Royal Geographical Society (with IBG) annual Medals and Awards recognise achievements in researching, communicating and teaching a wide range of geographical knowledge. The speeches and citations are a record of the 2024 celebrations, which occurred at the Society on 3 June 2024, with contributions from Vanessa Lawrence, Stephen Venables, Lily Kong, Chris Clark and Stefan Doerr.
Functionally graded Al2O3‐based ceramic systems by gel casting method
Authors: Topateş Gülsüm , Akça Erdem , Tür Yahya Kemal , Duran Cihangir 
Published: August 2024

AbstractFunctionally graded ceramic systems consisted of Al2O3/(Al2O3–ZrO2) and Al2O3/(Al2O3–Nd2Ti2O7) have been produced by gel casting. In Al2O3/ZrO2 systems, Al2O3 was gathered with three different Al2O3/ZrO2 mixtures with varying ZrO2 contents. For Al2O3/Nd2Ti2O7 system, Al2O3 layer was combined with 3 mol% Nd2Ti2O7‐doped Al2O3. All samples sintered at 1480 and 1540°C showed strong adhesion between layers without any crack formation. In the Al2O3/ZrO2 systems, both layers were intact; a distinct separation was observed, whereas a large reaction zone was observed for the Al2O3/Nd2Ti2O7 system as a consequence of reaction between both phases. The separation between layers for both systems was identified by SEM–EDX analyses. The hardness and wear tests of the samples showed that functional grading approach ensures combining various physical properties in a monolithic body.
Micromechanical properties of Al2O3–C refractories with aggregate/matrix interfacial layer by nanoindentation
Authors: Luo Jiyuan , Ding Donghai , Xiao Guoqing 
Published: August 2024

AbstractThe mechanical properties at microlevels are of important meaning for refractories while determining these values is of great challenges. In this contribution, a tailored grid nanoindentation test was employed to determine the micromechanical properties of low‐carbon Al2O3–C refractories featuring reduced brittleness with in situ magnesium aluminate spinel/carbon nanotubes (MgAl2O4/CNTs) compound interfacial layer between the aggregate and matrix. The micromechanical properties, especially Young's modulus (E) and specific fracture energy (Gc) of the aggregate, matrix, and aggregate/matrix interface area of the refractories, were determined and compared. Statistical analysis on the nanoindentation results of the aggregate and matrix in the reference sample and the sample with interfacial layer shows high consistency, which reveals the high feasibility of the method. The median microspecific fracture energy of the aggregate/matrix interface increases from 63.67 J m−2 of the reference group to 132.90 J m−2 of the sample with the compound interfacial layer, which means that higher energy is needed for the initiation and propagation of microcracks within the interfacial layer, accounting for the brittleness reduction of the refractories. Consistent conclusions were drawn from the nanoindentation test at microlevels along with the macrolevel thermal shock test and wedge splitting test.
Modelling heat stress effects on milk production traits in Tunisian Holsteins using a random regression approach
Authors: Soumri Nabil , Carabaño Maria Jesus , González‐Recio Oscar , Bedhiaf‐Romdhani Sonia 
Published: August 2024

AbstractThis study investigated the impact of temperature and humidity on milk production traits in Tunisian dairy cows, analysing population‐level trends and individual cow responses using various modelling techniques and heat stress (HS) indices. Two distinct datasets were used for this purpose: the first included 551,139; 331,654 and 302,396 test‐day records for milk, fat and protein yields, respectively. The second supplemented the production information with daily average (THIavg) and maximum (THImax) temperature‐humidity index (THI) data. Three main parts of analyses were conducted simultaneously: classical least squares, identification of HS thresholds and associated production losses and assessment of individual cow responses using random regression models (RRM) fitting various continuous functions that include/exclude individual effects. The best model, determined by goodness‐of‐fit measurements, was a cubic polynomial function that accounted for individual variation and THIavg as a heat load measure. HS thresholds were established at THIavg/THImax of 70/74 for milk yield, 50/55 for fat percentage, 59/66 for protein percentage, 54/63 for fat yield and 56/66 for protein yield. According to the fitted polynomial models, daily milk production traits showed a curvilinear decline with accelerated loss rates beyond the established thermal thresholds. However, for all models and thermal indices, maximum daily production losses remained below 164 g/day, 4.4 g/day and 6.1 g/day for milk, fat and protein yields, respectively. Despite these losses, the relatively high thermal thresholds and lower associated production losses suggest that Tunisian dairy cows can tolerate high heat loads. Moreover, observed variations in response patterns indicate potential for selecting heat‐tolerant individuals within this population.
Global patterns and determinants of phylogenetic beta diversity among liverwort floras
Authors: Qian Hong , Qian Shenhua , Wang Jian , Kessler Michael 
Published: August 2024

AbstractAimInvestigating phylogenetic beta diversity, and its turnover and nestedness components, can shed light on the evolutionary causes shaping the similarity (or dissimilarity) in composition between biological assemblages. Liverworts are important constituents of most terrestrial ecosystems worldwide but studies on phylogenetic beta diversity in liverworts are scarce. Here, we explore geographic patterns of phylogenetic beta diversity and its two components in liverworts across the world and evaluate the relative importance of dispersal limitation and environmental filtering processes in shaping beta diversity patterns at different spatial extents by relating phylogenetic beta diversity or phylogenetic turnover to geographic and climatic distances.LocationGlobal.TaxonLiverworts.MethodsWe conducted correlation and regression analyses to relate phylogenetic beta diversity and its two components (turnover and nestedness) to six variables representing current climate conditions and two variables representing historical (Quaternary) climate change, and to geographic and climatic distances at different spatial extents (global, continental, and regional).ResultsWe found that of the eight variables of current and historical climates considered, precipitation seasonality was the strongest determinant of phylogenetic beta diversity in liverworts. At the global extent, geographic and climatic distances explained similar amounts of the variation in phylogenetic turnover, whereas at the continental extent, climatic distance explained more variation than geographic distance in five of the seven continents, and at a regional extent (roughly a circle of 4000 km in diameter), geographic distances generally had a greater effect than climatic distance on phylogenetic turnover.Main ConclusionsWe conclude that both dispersal limitation and environmental filtering played an important role in shaping phylogenetic structure of liverwort floras, but their relative importance varies at different spatial scales and among geographic regions.
Dynamic degree centrality in stroke‐induced Broca's aphasia varies based on first language: A functional MRI study
Authors: Linazi Gu , Li Sijing , Qu Mei , Xi Yanling 
Published: August 2024

AbstractBackground and PurposeThis study sought to explore dynamic degree centrality (DC) variability in particular regions of the brain in patients with poststroke Broca aphasia (BA) using a resting‐state functional magnetic resonance imaging (rs‐fMRI) approach, comparing differences between Uyghur and Chinese BA patients.MethodsThis study investigated two factors, language and BA status, and divided patients into four groups: Uyghur aphasia patients (UA), Uyghur normal control subjects (UN), Chinese aphasia patients (CA), and Chinese normal subjects (CN) who underwent rs‐fMRI analysis. Two‐way analysis of variance (ANOVA) was used to calculate the comprehensive differences in dynamic DC among these four groups. Correlations between DC and language behavior were assessed with partial correlation analyses.ResultsTwo‐way ANOVA revealed comparable results for the results of pairwise comparisons of dynamic DC variability among the four groups in the right middle frontal gyrus/orbital part (ORBmid.R), right superior frontal gyrus/dorsolateral, and right precuneus (PCUN.R), with results as follows: UA < UN, CA > CN, UA < CA, and UN > CN (p < .05, with the exception of the p‐values for UA and UN in superior frontal gyrus/dorsolateral). In contrast, the opposite results were observed for the right calcarine fissure and surrounding cortex (CAL.R, p < .05).ConclusionThe observed enhancement of dynamic DC variability in ORBmid.R and PCUN.R among Chinese BA patients and in CAL.R in Uyghur BA patients may be attributable to language network restructuring. Overall, these results suggest that BA patients who use different language families may exhibit differences in the network mechanisms that characterize observed impairments of language function.
Effects of two dentifrices on the surface properties and staining susceptibility of polymer‐based materials
Authors: Babaier Rua , Alhotan Abdulaziz , Haider Julfikar , Silikas Nick , Watts David C. 
Published: August 2024

AbstractPurposeThis study examined the effect of whitening and abrasive regular dentifrices on the surface characteristics and stain susceptibility of polymer‐based CAD–CAM blocks subjected to artificial toothbrushing abrasion (TB).Materials and MethodsTwo resin composite blocks [CeraSmart (CS) and Grandio Blocs (GB)], one polymer‐infiltrated ceramic [Vita Enamic (VE)], and one direct resin composite [GrandioSO (RC)] were used to produce 60 specimens. The baseline mass, gloss, roughness, Vickers hardness (Hv), and color were measured after 7 days of water storage. The specimens were then separated into three TB treatment groups (n = 5): water control (C), regular daily dentifrice (R), and whitening dentifrice (W). Measurements were repeated post‐TB (20,000 cycles). All specimens were immersed in coffee, and the CIE ΔE00 was measured after 1, 7, and 14 days. Two‐way, one‐way ANOVA, and Tukey's post hoc tests were performed to determine any significant differences between the materials and TB groups. To determine the stain resistance, repeated measures of ANOVA, one‐way ANOVA, and Tukey's post hoc tests were used (α = 0.05).ResultsThe R and W mass changes were minimal (−3.77 to 3.16 g%). W reduced the gloss of all the materials by 12.6%–65%. All materials in W were slightly rougher (Ra, 0.107–0.144 μm) than those in R (Ra, 0.049–0.072 μm). The ΔE00 ranged from 0.6 to 1.6 in W and 0.4 to 1.4 in R. VE was the hardest material at baseline (Hv = 362), whereas brushing and staining lowered Hv in all TB groups (282.8–300.6). After brushing in W, VE, and RC were more susceptible to coffee stains than were CS and GB.ConclusionsThe whitening dentifrice roughened CAD–CAM specimens, reducing gloss, yet lightened some materials. Polymer‐infiltrated ceramic and direct resin composite specimens brushed with abrasive regular or whitening dentifrice resulted in more intense staining than the CAD–CAM resin composites.
Resolution of chronic inflammation and cancer
Authors: Tezcan Gulcin , Yakar Nil , Hasturk Hatice , Van Dyke Thomas E. , Kantarci Alpdogan 
Published: August 2024

AbstractChronic inflammation poses challenges to effective cancer treatment. Although anti‐inflammatory therapies have shown short‐term benefits, their long‐term implications may be unfavorable because they fail to initiate the necessary inflammatory responses. Recent research underscores the promise of specialized pro‐resolving mediators, which play a role in modulating the cancer microenvironment by promoting the resolution of initiated inflammatory processes and restoring tissue hemostasis. This review addresses current insights into how inflammation contributes to cancer pathogenesis and explores recent strategies to resolve inflammation associated with cancer.