bluuebunny/crossref_metadata_2025_split huggingface dataset:
Upregulation of Amy1 in the salivary glands of mice exposed to a lunar gravity environment using the multiple artificial gravity research system
Authors: Ouchi Takehito , Kono Kyosuke , Satou Ryouichi , Kurashima Ryuya , Yamaguchi Koji , Kimura Maki , Shibukawa Yoshiyuki 
Published: June 2024

Introduction: Space is a unique environment characterized by isolation from community life and exposure to circadian misalignment, microgravity, and space radiation. These multiple differences from those experienced on the earth may cause systemic and local tissue stress. Autonomic nerves, including sympathetic and parasympathetic nerves, regulate functions in multiple organs. Saliva is secreted from the salivary gland, which is regulated by autonomic nerves, and plays several important roles in the oral cavity and digestive processes. The balance of the autonomic nervous system in the seromucous glands, such as the submandibular glands, precisely controls serous and mucous saliva. Psychological stress, radiation damage, and other triggers can cause an imbalance in salivary secretion systems. A previous study reported that amylase is a stress marker in behavioral medicine and space flight crews; however, the detailed mechanisms underlying amylase regulation in the space environment are still unknown.Methods: In this study, we aimed to elucidate how lunar gravity (1/6 g) changes mRNA expression patterns in the salivary gland. Using a multiple artificial gravity research system during space flight in the International Space Station, we studied the effects of two different gravitational levels, lunar and Earth gravity, on the submandibular glands of mice. All mice survived, returned to Earth from space, and their submandibular glands were collected 2 days after landing.Results: We found that lunar gravity induced the expression of the salivary amylase gene Amy1; however, no increase in Aqp5 and Ano1, which regulate water secretion, was observed. In addition, genes involved in the exocrine system, such as vesicle-associated membrane protein 8 (Vamp8) and small G proteins, including Rap1 and Rab families, were upregulated under lunar gravity.Conclusion: These results imply that lunar gravity upregulates salivary amylase secretion via Rap/Rab signaling and exocytosis via Vamp8. Our study highlights Amy1 as a potential candidate marker for stress regulation in salivary glands in the lunar gravity environment.
The effect mechanism of perceived entrepreneurial environment on Chinese college students’ entrepreneurial intention: chain mediation model test
Authors: Lin Qicheng , Chen Yirong , Lai Junli , Zhang Xinyi 
Published: June 2024

IntroductionThis study aimed to explore the effect of perceived entrepreneurial environment among Chinese college students’ entrepreneurial intention and its underlying mechanism.MethodsBased on a survey of 445 college students from 5 universities with the perceived entrepreneurial environment assessment scale, the achievement motivation scale, the entrepreneurial self-efficacy scale, and the entrepreneurial intention questionnaire.ResultsThere were significant correlations among perceived entrepreneurial environment, achievement motivation, entrepreneurial self-efficacy, and entrepreneurial intention, and perceived entrepreneurial environment could significantly positively predict entrepreneurial intention. Achievement motivation and entrepreneurial self-efficacy played significant mediating roles between the perceived entrepreneurial environment and entrepreneurial intention. There were three paths that perceived entrepreneurial environment to influence entrepreneurial intention: One was the mediating role of achievement motivation; The second was the mediating role of entrepreneurial self-efficacy; The third was the chain-mediated role of both achievement motivation and entrepreneurial self-efficacy.DiscussionThe internal mechanism of the relationship between perceived entrepreneurial environment and entrepreneurial intention enriches the research results of entrepreneurial psychology among college students and provides a theoretical basis for training and guiding the entrepreneurship of college students.
Jumping with control: the interplay between psychological constructs and run-up variability in elite jumpers
Authors: Moura Larissa de Paula , Moura Nelio Alfano , Moura Tania Fernandes de Paula , Moura Túlio Bernardo Macedo Alfano , Brandão Maria Regina Ferreira 
Published: June 2024

ObjectivesThe purpose of this study was to examine the relationship between psychological aspects (emotional regulation, self-control, mood states, and perceived stress) and components of run-up variability in horizontal jumps and to conduct comparisons based on sex, events (long jump and triple jump), and contextual situations (training versus competition).MethodsA total of 10 elite-level athletes (five males and five females) with a mean age of 27.14 (±4.25) years were recruited for the study. All participants had competed nationally or internationally and had 13.10 (±3.48) years of athletic experience. Data were collected during competitions and training sessions for 5 weeks. The participants completed the Brunel Mood Scale, Emotional Regulation Questionnaire, Brief Self-Control Scale, and Visual Analogical Scale of Perceived Stress before each session. The components of run-up variability of successful and failed attempts were measured using video analysis. Data were analyzed using a t-test, Pearson’s correlation, and Cohen’s d.ResultsAthletes specializing in long jump and triple jump displayed similar psychological and run-up variability characteristics. However, females showed higher values for tension and depression, whereas males had higher run-up speeds and vigor. In competitions, athletes tended to have higher vigor, lower fatigue and confusion, an earlier beginning of the adjustment phase, fewer failed attempts, and higher run-up speed than during training. Emotional regulation is inversely related to depression in women during competitions, whereas higher self-control is associated with fewer failed jumps.ConclusionAthletes competing in the long jump and the triple jump do not differ in psychological traits and run-up characteristics, which suggests that similar training strategies can be used in both events. However, different solutions should be used considering the sex of athletes, with a particular focus on utilizing emotion regulation tools to modulate depression in female jumpers. It is recommended to include training sessions that simulate competition demands, primarily to ensure the early onset of the run-up adjustment phase.
The relationship between social and psychological factors with cognitive impairment after stroke: a prospective study
Authors: Li Yao , Tang Aijie , Ge Lili , Zhang Lin , Chen Ling , Xu Yuhua , Wang Li , Zhu Xiaoping , Wu Qian 
Published: June 2024

ObjectivesTo investigate the association between social and psychological factors and the risk of cognitive impairment following acute ischemic stroke.Materials and methodsA prospective study was conducted at Shanghai Tenth People’s Hospital from June 2021 to July 2022. The study focused on social and psychological factors, which were assessed using the Social Support Rating Scale (SSRS), Self-Perceived Burden Scale (SPBS), and Hamilton Depression Scale (HAMD) within 3 days after admission to the hospital. Cognitive function was evaluated using the Montreal Cognitive Assessment at 3 months post-stroke. Logistic hierarchical regression models were used to examine the association between these three indicators and cognitive impairment following a stroke.ResultsAmong these patients, cognitive function was assessed in 211 cases at the 3-month follow-up after the initial stroke event. At 3 months post-stroke, 118(55.9%) of the participants experienced cognitive impairment, while 93(44.1%) did not. The scores on the SPBS and HAMD showed significant associations with cognitive impairment at 3 months after stroke. The scores of SPBS [scores: 30~39 vs.&lt;20 points, odds ratio (OR)=2.993 (1.135–7.896); scores: ≥40 vs.&lt;20points, OR=7.382 (1.117–48.799); P=0.043] and the HAMD [scores: &gt;7 vs.≤7 points, OR=3.287(1.362~7.936); P=0.008]. There were no significant associations observed between SSRS and PSCI.ConclusionEarly screening for depressive symptoms and focusing on self-perceived burden can be beneficial for decision support for clinicians and improve cognitive function recovery at the 3-month mark post-stroke.
Inequity in uptake of maternal health care services in developing countries: a systematic review and meta-analysis
Authors: Gube Addisu Alemayehu , Murányi Edit , Vitrai Jozsef , Lohner Szimonetta 
Published: June 2024

BackgroundMaternal health service uptake remains an important predictor of maternal outcomes including maternal mortality. This systematic review and meta-analysis aimed to summarize the available evidence on the uptake of maternal health care services in developing countries and to assess the impact of place of residence, education status, and wealth index on the uptake of these services.MethodsWe examined the databases MEDLINE, Web of Science, Global Index Medicus, and Scopus until June 14, 2022. Cross-sectional studies done between 2015 and 2022 were considered. Mothers of reproductive age and all states of health were included in the study. Independently, two authors determined the eligibility of studies, extracted data, evaluated the risk of bias, and ranked the evidence’s degree of certainty. To combine the data, we performed a random-effects meta-analysis. The PROSPERO registration ID is CRD42022304094.ResultsWe included 51 studies. Mothers living in urban areas were three times more likely to receive antenatal care (OR 2.95; 95% CI 2.23 to 3.89; 15 studies; 340,390 participants) than rural mothers. Compared with no education, those with primary education were twice as likely to utilize antenatal care (OR 2.36; 95% CI 1.80 to 3.09; 9 studies; 154,398 participants) and those with secondary and higher education were six and fourteen times more likely to utilize antenatal care, respectively. Mothers in the second wealth index were twice as likely as mothers in the lowest wealth index to utilize antenatal care (OR 1.62; 95% CI 1.36 to 1.91; 10 studies; 224,530 participants) and antenatal care utilization increased further among mothers in the higher wealth index. We observed similar relative inequalities in skilled delivery care and postnatal care utilization based on the pace of residence, education, and wealth index.ConclusionIn developing countries, the problem of inequity in utilizing maternal health care services persists and needs considerable attention.
A study of latent profile analysis of empathic competence and factors influencing it in nursing interns: a multicenter cross-sectional study
Authors: Wang Jia , Xu Xiaoqing , Sun Jiaxin , Ma Yujia , Tang Peijuan , Chang Wenzhong , Chen Xia , Cui Yajuan , Su Mei , He Yan 
Published: June 2024

BackgroundEmpathy, as one of the fundamental principles of nursing professionalism, plays a pivotal role in the formation and advancement of the nursing team. Nursing interns, as a reserve force within the nursing team, are of significant importance in terms of their ability to empathize. This quality is not only directly related to the degree of harmony in the nurse–patient relationship and the enhancement of patient satisfaction, but also plays a pivotal role in the promotion of the quality of nursing services to a new level.AimThe objective of this study was to gain a deeper understanding of the current state of nursing interns’ empathic abilities. To this end, we sought to examine empathic performance under different profile models and to identify the key factors influencing these profile models.MethodsThe study utilized 444 nursing interns from 11 tertiary general hospitals in Inner Mongolia as research subjects. The study employed a number of research tools, including demographic characteristics, the Jefferson Scale of Empathy, and the Professional Quality of Life Scale. A latent profile model of nursing interns’ empathy ability was analyzed using Mplus 8.3. The test of variability of intergroup variables was performed using the chi-square test. Finally, the influencing factors of each profile model were analyzed by unordered multi-categorical logistic regression analysis.ResultsThe overall level of empathy among nursing interns was found to be low, with 45% belonging to the humanistic care group, 43% exhibiting low empathy, and 12% demonstrating high empathy. The internship duration, empathy satisfaction, secondary traumatic stress, only child, place of birth, and satisfaction with nursing were identified as factors influencing the latent profiles of empathy in nursing interns (p &lt; 0.05).ConclusionThere is considerable heterogeneity in nursing interns’ ability to empathize. Consequently, nursing educators and administrators should direct greater attention to interns with lower empathy and develop targeted intervention strategies based on the influences of the different underlying profiles.
True uterus didelphys in she-camel: a case report and review of literature
Authors: Mahdy Mohamed A. A. , Nasr Eldeen Mohammed S. 
Published: June 2024

BackgroundUterus didelphys is a rare congenital anomaly of the female reproductive tract characterized by a divided uterine cervix and body. It occurs due to abnormal development of the paramesonephric (Müllerian) duct. Different forms of uterus didelphys have been reported in several animal species, including bovine, equine, ewe, goat, swine, and bitch. However, there is no previous report that has documented a completely divided female genital tract in she-camel. Moreover, there is a lack of literature regarding this anomaly in animals. Therefore, the present study reports, for the first time, a rare case of a completely divided female genital tract in a she-camel. In addition, the existing relevant literature on uterus didelphys in different animal species is reviewed.Case presentationA female reproductive tract of she-camel, approximately 10 years old, with a history of previous successful pregnancy, was brought to the anatomy department following the slaughtering of the animal. Initial examination revealed a normal reproductive tract consisting of two ovaries, two fallopian tubes, a uterus, and a vagina. A closer examination revealed a completely divided vagina, with an external os opened into each part of the vagina, as well as a divided uterine body and cervix. Intrauterine infusion of saline through one external os confirmed complete separation of uterine body and cervix.ConclusionTo the authors’ knowledge, this is the first reported case of a completely divided female genital tract in a she-camel. This review summarizes the previous reports about uterus didelphys in farm animals.
Molecular Characterization and Expression Analysis of a Gene Encoding 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGR) from Bipolaris eleusines, an Ophiobolin A-Producing Fungus
Authors: Zhang Jianping , Yang Ke , Tang Wei , Yang Yongjie , Yu Xiaoyue , Lu Yongliang , Yu Liuqing 
Published: June 2024

Ophibolin A, a fungal sesterterpene, exerts a pivotal influence in a diverse array of biological processes, encompassing herbicidal, bactericidal, fungicidal, and cytotoxic activities. Sixty genes associated with sesterterpene compound biosynthesis were obtained from Bipolaris eleusines via transcriptome sequencing, and those closely linked to ophiobolin A biosynthesis were subsequently filtered. A gene encoding 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) that catalyzes the first committed step of ophiobolin biosynthesis in the mevalonic acid (MVA) pathway was isolated and characterized using RACE (Rapid Amplification of cDNA Ends) technology from ophiobolin A-producing fungus, B. eleusines. The full-length cDNA of the B. eleusines HMGR gene (BeHMGR) was 3906 bp and contained a 3474 bp open reading frame (ORF) encoding 1157 amino acids. Sequence analysis revealed that deduced BeHMGR had high homology to the known HMGRs from Pyrenophora tritici-repentis and Leptosphaeria maculans. It had a calculated molecular mass of about 124.65 kDa and an isoelectric point (pI) of 6.90. It contained two putative HMG-CoA-binding motifs and two NADP(H)-binding motifs. Induced expression analysis of the BeHMGR gene by methyl jasmonate treatment using quantitative fluorescence PCR showed that it significantly elevated after 3 h of methyl jasmonate treatment, peaked at 6 h, and then gradually decreased. This demonstrates that BeHMGR gene expression is induced by methyl jasmonate.
Persepsi Wisatawan Lokal pada Interior Onshore Floating Resort
Authors: Nastiti Ratna Andriani , Ayuswantana Alfian Candra , Tanadda Onna Anieko , Fata Ibrahim , Herwina Nevlin Cresentia , Dini Mazaya Islami 
Published: June 2024

Fenomena healing menjadi konsep yang cukup popular di Indonesia khususnya pasca kasus Covid-19 melanda beberapa tahun belakangan. “Healing” menjadi kata popular di laman pencarian google sebab kata ini memiliki makna pengganti kata “traveling”. Salah satu destinasi healing yang menarik adalah Bee Jay Bakau Resort, yang ada di Probolinggo. Sebagai contoh, salah satu destinasi uniq di kawasan pantai yang memiliki potensi ialah floating resort. Secara umum floating resort memberikan fasilitas menginap dengan pengalaman uniq berada di atas laut. Sehingga wisatawan dapat merasakan bagaimana hidup di atas laut dengan pemandangan yang dilengkapi dengan biota laut. Pengalaman terebut tentunya dapat tersampaikan kepada wisatawan dengan dukungan desain interior floating resort yang menarik dan memorable. Penelitian ini bertujuan untuk menganalisis persepsi wisatawan terhadap interior floating resort. Adapun metode yang akan dilakukan dalam penelitian ini adalah dengan metode kualitatif deskriptif dimana responden dipilih dengan menggunakan snowball sampling approach. Perolehan data dilakukan dengan interview pada responden dengan teknik wawancara semi-struktur, sehingga diperoleh data yang sesuai dengan penelitian. Hasil penelitian menjelaskan adanya perbedaan pada masing-masing persepsi wisatawan. Namun secara umum persepsi wisatawan berfokus pada aspek visual dan audial pada desain interior. Selanjutnya hasil penelitian ini diharapkan dapat digunakan sebagai acuan dalam mendesain interior floating resort khususnya pada kondisi pasca pandemic.
Clinical Pharmacology in Practical Healthcare, Education and Science
Authors: Гавриленко Л.Н. , Романова И.С. 
Published: June 2024

28 марта 2024 г. в УО «Белорусский государственный медицинский университет» проведено Республиканское совещание по итогам деятельности службы клинической фармакологии за 2023 год и перспективам развития, посвященное актуальным аспектам формирования и функционирования службы клинической фармакологии в Республике Беларусь, проблемам непрерывного образования по клинической фармакологии для врачей всех специальностей.
On March 28, 2024, the Belarusian State Medical University held a Republican meeting on the results of the activities of the clinical Pharmacology Service for 2023 and development prospects, devoted to topical aspects of the formation and functioning of the clinical pharmacology service in the Republic of Belarus, problems of continuing education in clinical pharmacology for doctors of all specialties.
Income analysis of Pryer Boat Charts fisherman in Lamuru Village, Tellu Siattinge District, Bone Regency)
Authors: Risna Risna , Tahang Hamzah , Fakhriyyah Sitti , Hasani M. Chasyim , Amiluddin Amiluddin 
Published: June 2024

Thys study aims to determine the income analysis of bagan cungkil fishermen in lamuru village, tellu siattinge sub-district, bone district and to determine the profit sharing system found in bagan cungkil fishermen in lamuru village, tellu siattinge sub-district, bone district. This research was conducted from June to July 2021 in Lamuru Village, Tellu Siatinge District, Bone Regency. The type of research used is a quantitative and qualitative approach with a survey method. The sampling technique used is the census method. As for the income analysis of bagan cungkil fishermen in Lamuru Village, Tellu Siattinge District, Bone Regency, it was carried out by calculating the total income consisting of 10 Bagan Cungkil business units in Lamuru Village, Tellu Siattinge District, Bone Regency with revenues of Rp. 30,372,680,000/year. The costs incurred were IDR 3,606,440,668. So that the income is Rp.26,766,239,332 or with an average of Rp.2,676,623,933/unit. The profit-sharing system in the Bagan Cungkil Business Unit in Lamuru Village, Tellu Siattinge District, Bone Regency is still based on the customs of the surrounding community, namely 50:50, where the ship owner gets 50% of the total income and the crew also gets 50% of income
THE USE OF ELECTROSPUN IRON OXIDE NANOFIBERS IN COATING FROZEN BEEFBURGER
Authors: Majd A. A.  , Alrubeii, A. M. S.  , L. T. Al–Hadedee  
Published: June 2024

This study was conducted on the in coating of beef burger using electrospun iron oxide nanofibers at two concentrations6, 8 % , to improve the chemical and physical properties of the beef burger during a 3-month frozen storage period. The results of the study showed that the addition of electrospun nanofibers contributed to reducing the total bacterial count, as well as the count of psychrophilic bacteria and coliform bacteria, to 4.88* 103, 4.62* 103, and 3.15* 101, 3.64 *101, respectively, and 2.15* 103, 2.49* 103 colony-forming units (CFU/g) respectively, during the final storage period. The moisture, protein, fat, and ash percentages in the frozen beef burger were found to be 60.12%, 19.09%, 19.31%, and 1.28%, respectively. The addition of iron oxide nanofibers also improved the water holding capacity of the frozen beef burger, with values of 49.16% and 39.69%, respectively. Furthermore, the pH values remained constant at 5.68 and 5.63, respectively, during the final storage period. The addition of nanofibers also reduced the peroxide value to 6.77 and 6.62 milliequivalents per kilogram, respectively, during the final storage period.The aim of this study was to investigate the effects of adding electrospun nanofibers to biopolymers used in beef burger on their qualitative properties.
Efektivitas Variasi Konsentrasi Air Perasan Jeruk Nipis sebagai Pengganti Komposisi Larutan Turk untuk Hitung Jumlah Leukosit
Authors: Annisa Istiana , Hasanah Mifroh , Mahardhika Rian Bayu Santya 
Published: June 2024

Standard turk solution is a solution used for manual leukocyte count examination including glacial acetic acid, gentian violet and distilled water. Lime fruit (Citrus aurantifolia swingle) is a type of orange that has a pH of 2.0. Both of these materials belong to weak acids that can lyse blood cells other than leukocytes which can be used to check leukocyte counts. The purpose of this study was to determine the effectiveness of lime juice as a substitute for turk solution with several concentrations. The research design used is descriptive. This study uses the SPSS method. The results of this study were that the sig value of the turk solution with several variations was 2% = 0.935, 3% = 0.326, 4% = 0.162 and 5% = 0.108 where all results were > 0.05 which can be concluded that there was no much difference between the control and all variation of orange juice but the highest significant variation is 2%.