bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary Valve Replacement With a Bovine Pericardial Valve
Authors: Neukamm Christian , Lindberg Harald L. , Try Kirsti , Døhlen Gaute , Norgård Gunnar 
Published: October 2014

Objectives: From a population of 90 patients after pulmonary valve replacement with a biological valve (Carpentier-Edwards Perimount valve), 56 of 80 available patients were examined five years after surgery. Background: Pulmonary valve replacement is needed in many patients with congenital heart disease. Homografts have limited availability and predictable degeneration, and mechanical valves require anticoagulation. No superiority of one kind of pulmonary valve replacement has been shown. Biological valves that are readily available are being used and evaluated in increasing numbers. Methods: In this cross-sectional study, five years following surgery, data were gathered from hospital charts, echocardiography, stress echocardiography, magnetic resonance imaging, and exercise testing. Results: In 90 patients, there were three new valve replacements, one early cardiac death, and four late noncardiac deaths. Echocardiographic assessment of the study group showed pulmonary Doppler velocities (m/s) before, after operation, and at five-year follow-up of 2.8 ± 1.1, 1.6 ± 0.4, and 2.3 ± 0.7, respectively. The assessed insufficiencies (0-3) at the same times were 2.3 ± 1.0, 0.3 ± 0.4, and 1.1 ± 0.8. Maximal oxygen uptake increased from 65.6% ± 10.1% to 77.1% ± 18.2% of predicted and QRS width increased by 7 ± 23ms. Valve degeneration could be associated with young age but not with diagnosis or valve size. Conclusion: In our study, the biological valve in the pulmonary position showed excellent mid-term results with few reoperations, low gradients, and mild to moderate insufficiency. Oversizing, in contrast to young age, was not a risk factor for valve degeneration. In younger patients, this allows later percutaneous replacement, reducing the need for further surgery. However, longer follow-up is needed.
Minimally Invasive Video-Assisted Surgical Closure of Atrial Septal Defects
Authors: Sabate Rotes Anna , Burkhart Harold M. , Suri Rakesh M. , Grogan Martha , Taggart Nathaniel W. , Li Zhuo , Schaff Hartzell V. , Dearani Joseph A. 
Published: October 2014

Objective: To compare the safety and effectiveness of video-assisted thoracic surgery (VATS) versus conventional median sternotomy (open) in the repair of secundum atrial septal defect (ASD) or patent foramen ovale (PFO). Design: Among 415 consecutive patients undergoing open or VATS ASD/PFO closure between 1993 and October 2012, 153 patients were compared using 2:1 frequency matching (n = 102 open vs 51 VATS). Matching variables include age, gender, body surface area, past medical history of neurologic events, and need of patch closure. Median age was 43 years (3-71 years), and 67% were female. Results: There were no early deaths in either group. There were no conversions to open sternotomy. Although mean cross-clamp time (14.5 ± 7.6 vs 26.3 ± 13.2 minutes, P < .001) and bypass time (31.7 ± 13.8 vs 60.9 ± 20.9 minutes, P < .001) were longer in the VATS group, patients who underwent VATS had shorter postoperative ventilation time (7.5 ± 6.4 vs 4.4 ± 2.8 hours, P = .03) with 62.7% extubated in the operating room, along with shorter intensive care unit stay (26.7 ± 10.8 vs 19.1 ± 9.9 hours, P < .001) and hospital stay (5.2 ± 1.9 vs 3.5 ± 0.9 days, P < .001). At early follow-up (mean 1.5 years, maximum 4.2 years), there was no difference in need for reintervention. Of the 27 patients who underwent VATS ASD/PFO closure for a neurologic event, none had a recurrence. Conclusion: The use of VATS provides a safe, equally effective alternative to conventional sternotomy for ASD/PFO closure, using a less invasive approach.
Evaluation of a Second-Generation Microtransesophageal Echocardiography Transducer and Software
Authors: Frank Lowell H. , Chelliah Anjali , Sable Craig A. 
Published: October 2014

Background: Transesophageal echocardiographic imaging of small infants has been limited because of equipment size. A newer miniaturized transducer has allowed for the imaging of even the smallest patients but has been limited by intermittent poor image quality because of hardware durability. A second generation of the transducer was developed to address this problem. The aim of this study was to evaluate the performance and durability of the second-generation transducer over multiple uses and to compare the image quality from the modified transducer and new software preset to the original transducer. Methods: Patients undergoing transesophageal echocardiography (TEE) based on clinical indications with the original or second-generation transducers were included in the study. All studies were reviewed for image quality and unacceptable image degradation, which was defined as imaging quality inadequate for clinical use. Study review was performed by two echocardiographers. Results: Using the original transducer, 37 studies were performed with a mean patient weight of 3.46 ± 0.89 kg (range 2.1-5.7). Using the second-generation transducer, 65 studies were performed with a mean patient weight of 4.87 ± 2.05 kg (range 2.2-13.8). Image quality was clinically inadequate in 8 of the 35 studies with the original transducer and in zero with the second generation ( P < .0001). Conclusions: The second-generation transducer allows for effective use of TEE even in the smallest infants and avoids the mechanical failures associated with the first-generation release.
Inflammatory Response to Hyperoxemic and Normoxemic Cardiopulmonary Bypass in Acyanotic Pediatric Patients
Authors: Kagawa Hiroshi , Morita Kiyozo , Uno Yoshimasa , Ko Yoshihiro , Matsumura Yoko , Kinouchi Katsushi , Hashimoto Kazuhiro 
Published: October 2014

Background: Hyperoxemic management during cardiopulmonary bypass (CPB) is still common, and there is no consensus about physiologic oxygen tension strategy (normoxemic management) during pediatric CPB. In this study, we compared the postoperative conditions and measures of inflammatory response among patients with acyanotic congenital heart disease subjected to either hyperoxemic or normoxemic management strategy during CPB. Methods: We studied 22 patients with a ventricular septal defect and pulmonary artery hypertension. The patients were divided into two groups. Group I (n = 9) received normoxemic management (PaO2 = 100-150 mm Hg) and group II (n = 13) received hyperoxemic management (PaO2 = 200-300 mm Hg) during CPB. There was no difference between groups with regard to age, body weight, duration of CPB, and aorta clamping time or preoperative pulmonary hypertension (pulmonary pressure/systemic pressure [Pp/Ps]). In each group, the blood samples to measure the cytokine levels were collected before and after the CPB. Results: Although we observed no statistically significant differences in postoperative intubation time, alveolar–arterial oxygen difference, creatine kinase MB level, and pulmonary hypertension (Pp/Ps) between group I (10.7 ± 13.4 hours, 197 ± 132 mm Hg, 148 ± 58.6 IU/L, 42.8% ± 22.1%, respectively) and group II (27.8 ± 36.5 hours, 227 ± 150 mm Hg, 151 ± 72.6 IU/L, 50.4% ± 16.0%, respectively), levels of median interleukin 6 and tumor necrosis factor α were lower in group I (129.8 and 17.0 pg/mL, respectively) than that in group II (487.8 and 22.5 pg/mL, respectively). Conclusion: During the CPB in acyanotic pediatric patients, normoxemic management can minimize the systemic inflammatory response syndrome associated with CPB. We can apply this physiologic oxygen tension strategy to surgical advantage during heart surgeries in acyanotic pediatric patients.
Daptomycin Experience in Patients with Human Immunodeficiency Virus and Resistant Gram-Positive Infections
Authors: Slim Jihad , Jimenez Humberto , Culshaw Darren , Patel Hina , Lamp Kenneth C. 
Published: October 2014

Objectives: This study was conducted to evaluate the clinical experience with daptomycin in the treatment of resistant gram-positive infections (GPIs) in patients with HIV infection. Methods: Using a retrospective, multicenter, and observational registry study, investigators assessed outcomes following daptomycin therapy in 78 patients (62 efficacy evaluable) infected with HIV and with resistant GPIs. Results: Overall, success rates by infection type were bacteremia 91% (20 of 22), endocarditis 91% (10 of 11), and bone/joint 100% (9 of 9). Success by pathogen was 93% (39 of 42), 93% (14 of 15), and 100% (5 of 5) for methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and methicillin-resistant coagulase-negative staphylococci, respectively. Daptomycin appeared to be well tolerated, with 9% having an adverse event possibly related to daptomycin and 4% discontinuing daptomycin. Conclusions: In HIV-infected patients, daptomycin appears to be a useful agent for treating resistant GPIs.
Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1
Authors: Umezu Tomohiro , Tadokoro Hiroko , Azuma Kenko , Yoshizawa Seiichiro , Ohyashiki Kazuma , Ohyashiki Junko H. 
Published: October 2014

Key Points
We established hypoxia-resistant cells that can mimic in vivo conditions of hypoxic bone marrow. Exosomal miR-135b derived from these cell lines enhanced endothelial tube formation under hypoxia via the HIF-FIH signaling pathway.
Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity
Authors: Stavenuiter Fabian , Mosnier Laurent O. 
Published: October 2014

Key PointsFactor Xa activates PAR3 in the presence of EPCR by noncanonical cleavage at Arg41. Noncanonical PAR3 activation induces Tie2 activation, upregulation and redistribution of ZO-1, and stabilization of tight junctions.
Natural history of patients with congenital dysfibrinogenemia
Authors: Casini Alessandro , Blondon Marc , Lebreton Aurélien , Koegel Jérémie , Tintillier Véronique , de Maistre Emmanuel , Gautier Philippe , Biron Christine , Neerman-Arbez Marguerite , de Moerloose Philippe 
Published: October 2014

Key PointsMajor bleeding, thrombosis, and postpartum hemorrhage are frequent in propositi and relatives with congenital dysfibrinogenemia. Hotspot mutations were not predictive of either phenotype or outcome.
Optimal power mean bounds for Yang mean
Authors: Yang Zhen-Hang , Wu Li-Min , Chu Yu-Ming 
Published: October 2014

Abstract
In this paper, we prove that the double inequality

M
p

(
a
,
b
)
<
U
(
a
,
b
)
<

M
q

(
a
,
b
)

holds for all

a
,
b
>
0

with

a
≠
b

if and only if

p
≤
2
log
2
/
(
2
log
π
−
log
2
)
=
0.8684
⋯

and

q
≥
4
/
3

, where

U
(
a
,
b
)

and

M
r

(
a
,
b
)

are the Yang and r th power means of a and b, respectively.

MSC:26E60.
An explicit algorithm for solving the optimize hierarchical problems
Authors: Kumam Poom , Jitpeera Thanyarat , Yarangkham Wararat 
Published: October 2014

Abstract
In this paper, we consider the variational inequality problem over the generalized mixed equilibrium problem which has a hierarchical structure. Strong convergence of the algorithm to the unique solution is guaranteed under some assumptions.

MSC:47H09, 47H10, 47J20, 49J40, 65J15.
Arthritis Robustus: review of a case of an “abnormal” rheumatoid
Authors: Prasad Kajal , Rath Deepak , Kundu Bijit Kumar 
Published: October 2014

Abstract

Introduction
Incidental discovery or diagnosis of Rheumatoid Arthritis where the patient remains blissfully unaware of his affection is a rare occurrence.

Case description
We present the case of a telephone wireman in whom Rheumatoid Arthritis neither affected his activities of daily living nor caused any deformity to develop. It remained asymptomatic till its incidental discovery during his admission for treatment of myocardial infarction.

Discussion and Evaluation
This presentation of Rheumatoid Arthritis is termed ‘Arthritis Robustus’ and goes against the very tenets of the picture of Rheumatoid Arthritis we have in our minds. The name given to this entity stems from the fact that these patients are mostly physical labourers i.e. ‘Robust’.

Conclusion
Rheumatoid Arthritis can very rarely be asymptomatic. The rarity of the entity can be inferred from the paucity of published literature.
Maize pollen deposition in relation to distance from the nearest pollen source under common cultivation - results of 10 years of monitoring (2001 to 2010)
Authors: Hofmann Frieder , Otto Mathias , Wosniok Werner 
Published: October 2014

Abstract

Background
Information on pollen dispersal is essential for the risk assessment and management of genetically modified organisms (GMOs) such as Bt maize. We analyzed data on maize pollen deposition at 216 sites in Germany, Switzerland, and Belgium from 2001 to 2010. All data were collected using the same standardized sampling method. The distances between sampling site and the nearest maize field ranged from within the field to 4.45 km.

Results
Maize pollen deposition was negatively correlated with distance from the nearest pollen source. The highest pollen deposition was within the field, but depositions of several thousand pollen grains per square meter were recorded over the kilometer range. A power function model most accurately described the relationship between deposition and distance from the nearest pollen source, rather than the exponential model currently used in EU risk assessment and management, which underestimates exposure for distances greater than 10 m. Regression analysis confirmed the high significance of the power relationship. The large variation in pollen deposition at a given distance reflected the influences of wind direction and other meteorological and site conditions. Plausible variations of single values and the predicted mean pollen count at a given distance were expressed by confidence intervals.

Conclusions
The model described here allows estimations of pollen deposition in relation to distance from the nearest field; therefore, it will be valuable for the risk assessment and management of GMOs. Our results indicate that buffer zones in the kilometer range are required to prevent harmful exposure of non-target organisms to GMOs.
Study of Prospects Related to Development of Hydrocarbons Exports in Black Sea Direction
Authors: Вотинов  , Votinov A. , Афанасьев  , Afanasev Valentin 
Published: October 2014

The increasing role of transport communications’ constructive improvement in the Black Sea region’s real
economy development is inextricably linked with the need to ensure it by hydrocarbon exports’ infrastructure
under the conditions of limited international cooperation and differentiation of services provided. In this paper
have been marked groups of problems characterizing factors of demand creation for energy resources in
modern world economy, has been revealed the Black Sea economic cooperation role in development of
oil and petroleum products’ export infrastructure, has been assessed the energy policy influence on the
Russian Federation&#180;s position at the global energy market. A development strategy of vertically integrated
oil company &#34;Rosneft&#34; at the national and international markets has been described, Russian vertically
integrated oil companies’ competitive advantages and weaknesses have been considered.
Marketing Priority of Strategic Planning
Authors: Шкардун  , Shkardun V. , Афанасьев  , Afanasev Valentin 
Published: October 2014

Systemological bases of marketing approach use to the strategic planning are considered in this paper. A
complex of techniques for determining the enterprise’s strategy level, based on preliminary assessment of
enterprise managers’ readiness to work in strategic planning conditions has been marked. A concept of
business objectives’ identification and classification based on consideration of influence groups’ interests
has been proposed. A conceptual model related to interaction between market subjects and enterprise’s
units during strategic planning information and analytical support has been described. A methodical
approach to marketing information system setting on strategic planning’s analytical problems resolution has
been Justified.
Municipal Entities’ Life Support System: Current State, Main Threats, Anti-crisis Policy
Authors: Демин  , Demin A. , Морозов  , Morozov V. 
Published: October 2014

Some questions related to analysis of theoretical concepts of &#34;municipal entity life-support system&#34; and
&#34;municipal entity competence&#34; to clarify their essential characteristics, generalizations of theory and practice
related to municipal entity life-support systems management and analysis of municipal entities’ competences
distribution system status, to identify the main trends of its development, to develop a model of competences
distribution between local authorities and a model of municipal entity life-support systems management
efficiency improving.
Capital Structure, Product Market Dynamics, and the Boundaries of the Firm
Authors: Hackbarth Dirk , Mathews Richmond , Robinson David 
Published: October 2014

We model a new product market opportunity as an option and ask whether it is best exploited by a large incumbent firm (integration) or by a small separate firm (nonintegration). Starting from a standard framework, in which value-maximizing investment and financing decisions are jointly determined, we show that integration protects assets in place value, whereas nonintegration protects option value and maximizes financial flexibility. We show that increases in standard measures of cash flow risk predict exploitation of new opportunities by specialized firms, whereas increases in product market competition (e.g., the risk of competitive preemption) predict exploitation by incumbents. We also show that alliances organized as licensing agreements or revenue-sharing contracts sometimes better balance the sources of value and thus may dominate more traditional forms of organization. These organizational equilibria arise from the dynamic interaction of the new opportunity’s option-like features with realistic competitive forces. This paper was accepted by Brad Barber, finance.
Detection of Clonal Evolution in Hematopoietic Malignancies by Combining Comparative Genomic Hybridization and Single Nucleotide Polymorphism Arrays
Authors: Hartmann Luise , Stephenson Christine F , Verkamp Stephanie R , Johnson Krystal R , Burnworth Bettina , Hammock Kelle , Brodersen Lisa Eidenschink , de Baca Monica E , Wells Denise A , Loken Michael R , Zehentner Barbara K 
Published: October 2014

Abstract

BACKGROUND
Array comparative genomic hybridization (aCGH) has become a powerful tool for analyzing hematopoietic neoplasms and identifying genome-wide copy number changes in a single assay. aCGH also has superior resolution compared with fluorescence in situ hybridization (FISH) or conventional cytogenetics. Integration of single nucleotide polymorphism (SNP) probes with microarray analysis allows additional identification of acquired uniparental disomy, a copy neutral aberration with known potential to contribute to tumor pathogenesis. However, a limitation of microarray analysis has been the inability to detect clonal heterogeneity in a sample.

METHODS
This study comprised 16 samples (acute myeloid leukemia, myelodysplastic syndrome, chronic lymphocytic leukemia, plasma cell neoplasm) with complex cytogenetic features and evidence of clonal evolution. We used an integrated manual peak reassignment approach combining analysis of aCGH and SNP microarray data for characterization of subclonal abnormalities. We compared array findings with results obtained from conventional cytogenetic and FISH studies.

RESULTS
Clonal heterogeneity was detected in 13 of 16 samples by microarray on the basis of log2 values. Use of the manual peak reassignment analysis approach improved resolution of the sample's clonal composition and genetic heterogeneity in 10 of 13 (77%) patients. Moreover, in 3 patients, clonal disease progression was revealed by array analysis that was not evident by cytogenetic or FISH studies.

CONCLUSIONS
Genetic abnormalities originating from separate clonal subpopulations can be identified and further characterized by combining aCGH and SNP hybridization results from 1 integrated microarray chip by use of the manual peak reassignment technique. Its clinical utility in comparison to conventional cytogenetic or FISH studies is demonstrated.
‘Alī Al-Wardī, ‘Texas sociologist’?
Authors: Bishop Elizabeth 
Published: October 2014

Abstract
In his analysis of a professional association and its tactics, John McCumber’s Time in the Ditch asserts, ‘American philosophy during the McCarthy era seems to have confronted difficulties well beyond those faced by other disciplines’. In response, Lewis Gordon developed a thesis around what he called a ‘teleological suspension of disciplinarity’, a willingness to go beyond disciplines in the production of knowledge. During the Cold War, ‘Alī al-Wardī completed his training at the University of Texas at Austin, where he earned two graduate degrees. This article addresses al-Wardī’s early work in a series of historical and regional perspectives: first, referring to C. Wright Mills as a model for a ‘Texas sociologist’; second, identifying Sociology Department faculty members whom al-Wardī thanked in his thesis; and, through them, revealing a network of scholarship and activism identified with Cold War Texas.
Soziologie und Ökonomie im Irak: Reflexionen über das Werk von Ali Al-Wardi zu seinem 100sten Geburtstag
Authors: Schuber Barik 
Published: October 2014

Abstract
Based on Ali al-Wardi’s theoretical innovations, the article investigates the relatively new phenomena of the rentier state and society in Iraq as well as the ongoing political conflict between the different social groups and confessions as a battle about economic and financial resources related to the oil economy and to rent seeking. The discourse also highlights the issue of social justice accomplished by al-Wardi as a core socio-economic problem since the early period of Islam and influencing the political and confessional conflicts throughout the history of Iraq. Al-Wardi presented a great vision on plurality of society and how to build a multicultural, multi-ethnic nation in Iraq.
Reflections on a Mentor
Authors: Al-Haidari Ibrahim 
Published: October 2014

Abstract
This article positions the critical ideas of Ali al-Wardi on Iraqi society in general and its personality in particular, both its contradictions and duality between Bedouin and urban natures. The author maintains that these characteristics became much more relevant after the Anglo-American occupation of Iraq, which released the repressed tendencies of the Iraqi personality. The resurgence of these tendencies is reflected in the expressions of violence and terrorism which beset Iraq today. The author concludes by saying ‘we have to understand our reality […] and critically evaluate what is negative about ourselves [Iraqis]. We have to re-examine our intellectual discourse, social behaviour and political orientations.’ The author calls upon Iraqis to look at al-Wardi’s analysis of Iraq’s history in order to move forward.