bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous Nitrogen Fixation and CO2 Conversion via Magnetic Field Stabilized Glow Discharge (MSGD)
Authors: Liu YueXi , Li ZhiYu , Yang LiCheng , Pei XueKai , Nie LanLan , Lu XinPei 
Published: February 2025

ABSTRACTA Magnetic Field Stabilized Glow Discharge (MSGD) device is used to perform nitrogen fixation (NF) and CO2 conversion at atmospheric pressure using N2‐CO2 and air‐CO2 gas mixtures. It is found that for N2‐CO2 and air‐CO2 gas mixtures, the CO concentration increases with the CO2 volume fraction, reaching a maximum of 56 198 ppm at 100% CO2, and the corresponding energy cost for CO2 conversion is the lowest at 0.61 MJ/mol, while the energy efficiency of CO2 conversion reaches its highest at 46.7%. For N2‐CO2 discharge, the lowest energy cost for NF (11.24 MJ/mol) occurs at a gas ratio of approximately 1:1 (N2: CO2), with a NOx concentration of 2968 ppm. For air‐CO2 discharge, the lowest NF energy cost (2.59 MJ/mol) is achieved with pure air, resulting in a NOx concentration of 12 103 ppm. As the CO2 volume fraction increases, the NOx concentration decreases while NF energy cost rises. In both discharge scenarios, the overall energy efficiency for combined NF and CO2 conversion increases with the CO2 volume fraction. Further analysis reveals that the reduced electric field of the MSGD is approximately 49.6 Td, under which 90% of the electron energy is transferred to the vibrational states of N2 and CO2. Consequently, NO in the products is primarily generated through the Zeldovich mechanism, while CO is mainly produced via the vibrational dissociation of CO2.
Estrogen and Cyp1b1 Regulate Pparγ in Pulmonary Hypertension Through a Ubiquitin‐Dependent Mechanism
Authors: Chen Jingyuan , Chen Xinping , Agrawal Vineet , Moore Christy S. , Blackwell Tom , Rathaur Nivedita , Gladson Santhi , Rathinasabapathy Anandharajan , Hemnes Anna , Austin Eric , West James 
Published: February 2025

ABSTRACTFemale sex increases risk of Group I pulmonary arterial hypertension by roughly threefold, but the mechanism is unclear. Low expression of Cyp1b1, an enzyme that metabolizes estrogens, is associated with disease penetrance, particularly in women. We previously found that lower Pparγ levels in murine PAH models, which may drive disease, are rescued by estrogen blockade. The goal of the current studies was to examine interaction of estrogen, Cyp1b1, and energy metabolism in cell culture and in knockout mice. We found that both estrogen and siRNA to Cyp1b1 resulted in reduction of Pparγ at a protein, but not transcript level, in addition to regulating Pparγ cofactors. siCyp1b1 reduced both basal and maximal respiration rates in a fatty acid oxidation Seahorse protocol. This Pparγ inhibition could be eliminated by blocking ubiquitination. RNA‐seq suggested that Cyp1b1 may be having important pulmonary hypertension effects both in concert with and independently of its effect on estrogen. Cyp1b1 knockout mice have lower Pparγ levels than WT mice both in normoxia and hypoxia, and develop mild pulmonary hypertension on a high fat diet. RNA‐seq on their lungs reflected similar pathways to those altered in endothelial cells alone – lipid metabolism, cytokines, and vasoreactivity‐associated genes, among others, but added genes associated with circadian rhythm. These data suggest multiple potential points for intervention in estrogen and Cyp1b1 mediated etiology of PAH, in particular Pparγ ubiquitination, but also suggests that both the difference between E2 and 16aOHE and the impact of Cyp1b1 is more complex than simply “degree of estrogenicity”.
Quantum Signatures of Chaos in Anisotropic Quantum Rabi Model
Authors: Wang Shangyun , Chen Songbai , Jing Jiliang , Wang Jieci , Fan Heng 
Published: February 2025

AbstractQuantum chaos is an intriguing topic and has attracted a great deal of interests in quantum mechanics and black hole physics. Recently, the exponential growth of out‐of‐time‐ordered correlator (OTOC) has been proposed to diagnose quantum chaos and verify the correspondence principle. Here, good correspondence is found between the linear entanglement entropy and the semiclassical phase space structures in the anisotropic quantum Rabi model. The Loschmidt echo in the chaotic sea decays more faster than that in the stable island. However, the OTOCs grow exponentially at early times for the initial states centered both in the chaotic and stable regions. The exponential growth of the OTOC is attributed to quantum collapse that provides a novel mechanism of yielding exponential growth of the OTOC in quantum systems. Moreover, the quantum collapse effect is more obvious for the initial states centered in the chaotic one. The results show that in the anisotropic quantum Rabi model, the linear entanglement entropy, and Loschmidt echo are more effective than OTOC for diagnosing quantum chaotic signals.
pH Controlled Twist‐Angle Dependent Interfacial Quantum Tunneling in Multilayer Molecular Moiré Superlattices of p‐Phenylenediamine
Authors: Dey Ujjala , Chattopadhyay Arun 
Published: February 2025

AbstractMolecule‐based electronic circuits and device components may bring novel aspects in their functioning based on quantum phenomena that may not be attainable using conventional architecture. In order to implement such concepts development of well‐defined assemblies that enable energy transfer, mass, and charge transports across several length scales is necessary. Herein it is reported that multilayer molecular moiré superlattices may provide an initial direction for attaining the abovementioned objectives. For example, multilayered 2D moiré superlattices of p‐phenylenediamine showed easily identifiable twist angle‐dependent electrical conductivity at each interface, as measured for the nanosheet using conductive atomic force microscopy. The absence of water molecules at the interfaces, as compared to the layered water molecules in the lattices, lowered the electron tunneling barrier and thus, increased the conductivity. Importantly, protonation and deprotonation of the superlattices in the dispersion resulted in high interfacial currents with about three orders of magnitude increase for the former. These results are further explained by density of states calculations along with carrier density and simulated scanning tunneling microscopy (STM) plots.
Green Synthesis, Characterization, and Biomedical Applications of Iron Nanoparticles Synthesized from the Ethanolic Extract of the Aerial Part of Micromeria biflora
Authors: Rauf Abdur , Ibrahim Muhammad , Ahmad Zubair , Muhammad Naveed , Al‐Awthan Yahya S. , Bahattab Omar S. , Rami Saeed Hameed , Bawazeer Saud , Ullah Imran , Thiruvengadam Rekha , Kondapavuluri Benod Kumar , Thiruvengadam Muthu 
Published: February 2025

AbstractThis study explored the synthesis and characterization of the iron nanoparticles (FeNPs) using Micromeria biflora extract. The rapid reduction of iron ions, evidenced by a distinct color change, signifies an efficient interaction, leading to successful FeNPs formation. UV–visible spectroscopy confirmed the synthesis, revealing an absorption peak at 295 nm that intensified over time. Fourier transform infrared (FTIR) spectroscopy demonstrates phytochemical involvement. Field emission scanning electron microscopy (FESEM) images displayed cuboctahedron‐shaped NPs with various facet formations, which are crucial for diverse applications. DISCUS package was used to simulate the shape and decorate the surface with organic molecules obtained from the extract. Energy dispersive X‐ray spectroscopy (EDS) was used to confirm the elemental composition. Additionally, potential applications, including enzyme effects and sedative and anti‐inflammatory properties, were explored. The extract and FeNPs showed anticancer effects against MDR2780AD cell lines, with IC50 values of 1.99 and 0.91, respectively. The tested FeNPs showed 92.22%, 76.22%, and 88.23% inhibitory effects against urease, CA‐II, and XO, respectively. The maximum percentage analgesic effects of the extract (100 mg/kg) and FeNPs (10 mg/kg) were 65 and 82, respectively. The maximum anti‐inflammatory effect was observed at the third hour of treatment. The anti‐inflammatory effect of FeNPs (90%) was superior to that of the extract (60%).
MXene‐Based Nanomaterials for Pollution Remediation: A Review
Authors: Swain Krishna Kumari , Pradhan Sunil Kumar , Late Dattatray J. 
Published: February 2025

AbstractMXenes, which are an incredibly new class of 2D nanomaterials with a variety of possible applications, including nitrides, metal carbides, and carbonitrides, have attracted a lot of attention recently. Hydrophilicity, electron richness, a high specific surface area, a large number of highly active surface sites, and an abundance of surface terminations are some of MXene's characteristics. The capacity of MXene to adsorb a wide range of contaminants, such as pesticides, heavy metals, colors, and pharmaceuticals, is a notable feature. The most recent MXene structure, synthesis, characteristics, and various applications are covered in this review paper. In addition, there is a lot of emphasis on MXenes' adsorption capability and the factors that affect it for the removal of various contaminants (such as organic pollutants, heavy metals, medicinal compounds, radionuclides, etc.). It highlights the surface modification methods for MXene's removal of various contaminants, including intercalation, acidification, and alkalization. Finally, the future prospects for research in all areas of environmental and pollution remediation are covered in this paper.
Efficient Methylene Blue Removal From Water via Graphene Oxide‐Based Composite Cryogel Column
Authors: Küçük Melike , Bakhshpour‐Yücel Monireh , Osman Bilgen , Tümay Özer Elif 
Published: February 2025

AbstractIn this study, a composite poly(2‐hydroxyethyl methacrylate)/graphene oxide (PHEMA‐GO) cryogel column was developed for removal of methylene blue (MB) from aqueous solution. The PHEMA‐GO composite cryogel column was synthesized by adding GO into cryogelation mixture and comprehensive characterization studies were conducted via Fourier Transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), mercury porosimetry, and swelling study. The total porosity was determined as 66.72%. The pore size was in the range of 4.31–220.6 µm. The MB adsorption capacity of PHEMA‐GO cryogel column was investigated considering different parameters, including GO amount, pH, contact time, ionic strength, temperature, and initial MB concentration. The maximum MB amount adsorbed amount onto the PHEMA‐GO composite cryogel column was determined as 253 mg/g at 298 K (pH:5.3). The adsorption data were obeyed to Langmuir isotherm model and pseudo‐second‐order kinetic model. The adsorbed amount of MB was not affected from ionic strength, which is important for the dye removal from the textile wastewater. The composite cryogel column was reused 10 times without a decrease in the MB adsorption capacity. The application potential of the PHEMA‐GO composite cryogel column was demonstrated using a real textile wastewater sample.
Medicinal Chemistry of Khellin and Its Synthetic Derivatives: Progress and Future Potential in Drug Discovery
Authors: Kumar Amit , Chutia Deexa , Ambala Srinivas , Kumar Sanjay , Das Archana Moni 
Published: February 2025

AbstractKhellin (1) is a natural furanocoumarin found in Ammi visnaga majus, renowned for its abundance of biological activities in various physiological conditions, including tumors, bacterial infections, inflammation, viral fibrosis, obesity, respiratory disease, and diabetes. Based on extensive site‐selective chemical modifications of 1, various new chemical entities (NCEs) with enhanced bioavailability, potency, pharmacokinetics, and druggability have been developed over the years. Furthermore, the mechanisms of action at the molecular and cellular level have been thoroughly investigated in conjunction with preclinical studies. In this article, we present the medicinal chemistry of 1 and its derivatives in diverse drug discovery efforts covering the period from 2015 to the present. We have also elucidated the future perspectives, challenges, and limitations. We posit that this review will elucidate areas where 1 can be more beneficial in identifying hits and leads in drug discovery and enhance knowledge regarding its therapeutic applications.
Competitive overlap as a signal in expert partner choice: Evidence from patent law firm selection
Authors: Borchhardt Geoffrey , Kovács Balázs , Rogan Michelle 
Published: February 2025

AbstractResearch SummaryIn market networks, firms regularly seek partners with needed expertise, but these partners often work with the firms' competitors. How such second‐order competitive overlap affects partner selection is unclear. Prior theory assumes firms view networks as “pipes” and emphasizes flows of competitor information via the shared partner as key in partner selection. We propose that firms also view networks as “prisms” and use competitive overlap as a signal of a potential partner's expertise. Hence, firms may prefer partners with competitive overlap. We find support for our claims in the patent law firm selection context. Furthermore, higher competitive overlap leads to slower patent acceptance but results in broader patents, implying that the competitive overlap expertise signal reduces search costs without significant performance loss.Managerial SummaryWhen selecting expert partners like law firms or consultants, some companies may consider avoiding firms that also serve their competitor. However, when little is known about potential partners, this “competitive overlap” might be a way to assess their quality. We found that firms are more likely to choose patent law firms who work with their competitors. This occurs because a competitor's choice signals that partner's expertise. Companies rely on this signal most when they lack direct experience with potential partners or when entering new technological domains. While working with partners who serve competitors might slightly increase processing times, it can increase patent protection without compromising overall performance. These findings suggest that avoiding partners based solely on competitive overlap may limit access to valuable expertise.
Electrothermally‐Driven Carbon Nanotube Fiber Artificial Muscle With Endomysium‐Inspired Sheath and Multifilament Core
Authors: Zhu Sufeng , Zhao Zenghui , Di Jiangtao , Dong Xufeng , Qi Min 
Published: February 2025

AbstractElectrothermally‐driven carbon nanotube (CNT) fiber artificial muscles have attracted considerable interest in the fields of soft robotics, sensors, and intelligent control, owing to their excellent flexibility, abundant guest material sources, lightweight properties, rapid response, and ease of control. Nevertheless, their practical application has been impeded by the limited contractile stroke and contractile stress under high load conditions. Drawing inspiration from the physiological structure of muscle fiber, this study reports an endomysium‐inspired‐sheath artificial muscle (ESM). The ESMs are characterized by polydimethylsiloxane (PDMS) sheaths that mimick the endomysium, and multifilament cores made from CNT fibers imitating the myofibrils. The ESMs demonstrate excellent actuation performance, achieving maximum contractile stress of 40.1 MPa, the highest reported value among electrothermally‐driven CNT fiber artificial muscles. The ESMs also demonstrate large contractile stroke and high work capacity under heavy loads. Furthermore, a crawling robot with the capacity of carrying loads, driven by a single ESM, is developed to demonstrate the practical application potential of ESMs.
Innovative Design of a Double‐Layer Gradient Coating for Dendrite‐Free and Ultrastable Zinc Anodes
Authors: Li Wanting , Li Liansheng , Fu Xiangxiang , Hu Yangming , Deng Yuanfu 
Published: February 2025

AbstractThe rampant “top‐growth” dendrites, hydrogen evolution reaction (HER), and zinc (Zn) self‐corrosion severely impede the further development of rechargeable aqueous zinc ion batteries. To address these challenges, a novel double‐layer gradient coating consisting of a zincophilic Sn inner layer and an organic polymer outer layer (OSA/PAM@Sn) is constructed on the surface of the Zn anode. The organic outer layer, composed of cross‐linked oxidized sodium alginate and polyacrylamide (OSA/PAM), not only serves as a physical barrier to isolate active water but also accelerates Zn2+ diffusion by facilitating the desolvation process of [Zn(H2O)6]2+ due to its plentiful polar functional groups, thereby effectively suppressing the detrimental HER and Zn self‐corrosion. Simultaneously, the loose Sn inner layer can offer abundant nucleation sites to induce uniform “bottom‐to‐top” Zn deposition with low overpotential. Benefiting from the synergistic effect of the designed double‐layer gradient coating, the OSA/PAM@Sn‐Zn anode exhibits remarkable reversibility, with lifespans of over 5000 and 1200 h at 1 mA cm−2–1 mAh cm−2 and 5 mA cm−2–5 mAh cm−2 in symmetric cells, respectively. Additionally, the MnO2||OSA/PAM@Sn‐Zn full battery also displays an improved rate performance and cycle stability. This work emphasizes the importance of synergistic effects in interface design to achieve side reaction‐free and dendrite‐free Zn anodes.
Selective A‐Site Exsolution and Phase Transition in Perovskite Electrode for Efficient Flexible Znic‐Air Batteries
Authors: Zhang Wenyu , Zhang Nan , Zhu Wenhui , Zhao Ling , Gong Yansheng , Jin Jun , Wang Rui , Wang Huanwen , He Beibei 
Published: February 2025

AbstractZinc‐air batteries (ZABs) are highly promising for flexible electronics due to their high energy density and cost‐effective. However, their practical application is impeded by the sluggish kinetics of the oxygen evolution and oxygen reduction reactions (OER/ORR). This study presents a novel design featuring BaO nanoparticles anchored on layered perovskite PrBaMn1.5Co0.5O6‐δ (PBMC) nanofibers, fabricated through a plasma method. Notably, the plasma treatment induces the selective exsolution of A‐site Ba onto the perovskite surface, while simultaneously driving the transformation of PBMC from a simple perovskite to a layered perovskite, resulting in a unique BaO/PBMC heterostructure. Theoretical calculations demonstrate that the construction of the BaO/PBMC heterojunction regulates interfacial electronic redistribution, thereby lowering energy barriers for both OER and ORR. Consequently, the BaO/PBMC air electrode exhibits superior peak power density and enhanced stability in flexible solid‐state ZABs, compared to the pristine PBMC cathode. Selective A‐site exsolution coupled with phase transition, featuring a unique alkaline‐earth metal oxide/perovskite heterostructure, may offer new insights for energy conversion technologies.
DNA‐Enabled Self‐Resetting Electrochemical Sensor for microRNA Detection
Authors: Yang Xu , Yu Chenhong , Yang Bei , Jiang Chu , Gao Rui , Li Weiying , Wang Jianbang , Zhang Tao , Liu Huajie , Liu Dongsheng 
Published: February 2025

AbstractNucleic acids, such as microRNA and circulating tumor DNA, are widely utilized potential biomarkers for early disease diagnosis. Electrochemical sensors with high sensitivity play a significant role in quantitative bioanalysis, however, target molecules during detection usually bind to probes and limit their reusability. Powered by DNA/RNA fuel and enzyme‐based fuel consumption unit, dissipative DNA systems can perform periodic tasks in a self‐resettable manner. Here, a self‐resetting electrochemical sensor is reported for miRNA detection based on dissipative DNA networks. The target microRNA‐21 (miRNA‐21) invades the incumbent strand and activates the strand displacement process. Released ferrocene‐modified strands bind to the probe on the electrode surface for accurate detection. The miRNA within RNA/DNA heteroduplex will then be digested by RNase H to free the incumbent strand which replaces the ferrocene strand and restores the probe to the initial state. It is found that the detection limit of this self‐resetting electrochemical sensor is 0.35 pM for the third cycle. The self‐resetting electrochemical sensor can not only achieve lower detection limits, and maintain repeatability and stability in complex matrices, but also reduce the detection cost of electrochemical sensors. It is envisioned that many real‐life applications can be initiated such as analyzing various oligonucleotide biomarkers during early cancer diagnosis and bioanalysis.
Successful Management of Refractory Otitis Media Using Allergen‐Specific Immunotherapy in a Dog
Authors: Kim Jihyun , Lee Ji‐Hye , Kim Yeji , Song Yunji , Kim Ha‐Jung 
Published: February 2025

ABSTRACTBackgroundAllergen‐specific immunotherapy (ASIT) is a highly effective treatment for atopic dermatitis. In humans, it has been reported to be significantly more effective than medication alone for the treatment of otitis media. ASIT can also be used in dogs, but it is not typically the first‐line treatment for otitis externa and media.ObjectivesThis case report describes the successful management of refractory otitis media in a dog with frequent abscess recurrence following total ear canal ablation (TECA) using ASIT.MethodsA 9‐year‐old spayed female American Cocker Spaniel presented with a head tilt and a recurrent abscess adjacent to the left TECA site. A dermatological examination revealed secondary pyoderma. In open‐mouth view radiography and CT, fluid in the tympanic bullae and lysis of the tympanic bullae wall were observed. The TECA was repeated twice and anti‐inflammatory medication was administered, but the lesions reappeared. As a fundamental treatment, ASIT was included in the therapy.ResultsAfter ASIT, the symptoms did not reoccur, even though the use of prednisolone was gradually reduced and discontinued over a period of two months. Currently, only ASIT has demonstrated progress in managing the patient's condition, even a year after discontinuing other medications. The patient's symptoms have not recurred and are well managed.ConclusionsA case of refractory otitis media, induced by atopic dermatitis, was effectively managed with ASIT over a prolonged period in a dog.
Investigation of Tilapia (Oreochromis niloticus) Mortality Events Targeting Tilapia Lake Virus Disease (TiLVD) in Bangladesh
Authors: Akter Mst. Sabrina , Punom Nusrat Jahan , Eshik Md. Mostavi Enan , Ahmmed Shawon , Rabbane Md. Golam , Rahman Mohammad Shamsur 
Published: February 2025

ABSTRACTBackgroundTilapia lake virus (TiLV) is an emerging threat to the global tilapia industry. In early 2017, FAO declared that Bangladesh was in a high‐risk zone of TiLV disease (TiLVD) spread.ObjectivesConsidering the current scenario, the present work was designed to investigate the occurrence of TiLV in cultured Nile tilapia (Oreochromis niloticus) causing TiLVD in Bangladesh.MethodsIn this study, several unusual tilapia mortality incidences were investigated. A total of 102 pooled organ samples of 102 tilapia fish were collected from 34 ponds of 25 farms in the regions of 12 Upazilas in Bangladesh from May to October 2019. As a part of the classical approach, histopathological analysis was performed. For molecular identification, both conventional and real‐time PCR were used as diagnostic tools to identify TiLV in farm‐raised Nile tilapia.ResultsA total of 12 representative organ samples did not show any pathognomonic lesions related to TiLV infection in histopathological analysis. Conventional and real‐time PCR assays yielded negative results for TiLV.ConclusionsIn our investigation, no trace of TiLV was detected in the studied samples. A large‐scale study involving a broader range of samples collected across Bangladesh, along with the application of a viral metagenomics approach, could provide valuable insights into the unusual mortalities of tilapia in the country.