bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non‐Conductive and Conductive Washable Amylopectin‐Mastic Gum Adhesives for On‐Skin Applications
Authors: Al Boustani George , Xu Zhuoran , Teshima Tetsuhiko F. , Bichlmaier Lukas , Nikić Marta , Hiendlmeier Lukas , Sayn‐Wittgenstein August , Tüzün Defne , Inoue Shigeyoshi , Wolfrum Bernhard 
Published: August 2024

AbstractThe investigation of a skin adhesive based on amylopectin and mastic gum for attaching skin sensors are reported. The material provides reliable adhesion and is, at the same time, readily washable from the skin due to the hydrophilic character of the amylopectin compound. The effect of water and glycerol content on the adhesion properties in combination with polyimide‐based substrates is assessed and optimize the material for homogeneous and washable on‐skin applications. This results show that the adhesive material can withstand a shear stress of 88.7 ± 5.30 kPa in a lap shear test. The adhesive material can also be easily rendered conductive by adding sodium chloride. Impedance spectroscopy is performed on the conductive adhesive material to assess the impedance behavior during drying conditions over 24 h in comparison to commercial electrolyte gel. While the conductive adhesion material's initial impedance is slightly higher than the commercial gel, the long‐term assessment demonstrates a significantly improved stability over time. In conclusion, this study develops a skin adhesive combining amylopectin and mastic gum, demonstrating promising adhesion strength and conductivity properties, thus potentially addressing current stability challenges in skin‐sensor applications.
High‐Performance Flexible PbS Nanofilm Wavelength Sensor with Detection Region Ranging from DUV to NIR
Authors: Liang Feng‐Xia , Hu Yi , Zhu Zhi‐Guo , Wu Zhi‐Cheng , Yu Jie , Liang Li‐Yan , Wang Jiang , Wang Li , Wu Chun‐Yan , Song Pingan , Luo Lin‐Bao 
Published: August 2024

AbstractIn this study, on the fabrication of a flexible wavelength sensor is reported, which is achieved by growing a layer of lead sulfide (PbS) nanofilm on both sides of a polyethylene terephthalate substrate using the chemical bath deposition method, followed by the deposition of two parallel Au interdigital electrodes. Experimental result shows that the photocurrent ratio of the two photodetectors monotonically decreases with increasing wavelength in the range from 265 nm (UV) to 2000 nm (NIR), indicating that the incident light wavelength can be distinguished by the photocurrent ratio. Notably, the as‐constructed wavelength sensor exhibits superior performance compared to most previously reported filter‐less designs, achieving an average absolute error of 11.5 nm and an average relative error of 1.1%. It is also found that the sensor exhibits excellent mechanical flexibility and environmental stability. Furthermore, by introducing the back‐end circuit, real‐time detection of the wavelength of monochromatic light and the peak wavelength of LED light are achieved, with detection errors not exceeding 2.8% and 2.6%, respectively. It is believed that the flexible PbS nanofilm wavelength sensor prepared in this study has potential application in future portable and flexible optoelectronic devices.
Dopaminergic Neurons in Zona Incerta Drives Appetitive Self‐Grooming
Authors: Jiang Zhiying , He Michelle , Young Claire , Cai Jing , Xu Yuanzhong , Jiang Yanyan , Li Hongli , Yang Maojie , Tong Qingchun 
Published: August 2024

AbstractDopaminergic (DA) neurons are known to play a key role in controlling behaviors. While DA neurons in other brain regions are extensively characterized, those in zona incerta (ZITH or A13) receive much less attention and their function remains to be defined. Here it is shown that optogenetic stimulation of these neurons elicited intensive self‐grooming behaviors and promoted place preference, which can be enhanced by training but cannot be converted into contextual memory. Interestingly, the same stimulation increased DA release to periaqueductal grey (PAG) neurons and local PAG antagonism of DA action reduced the elicited self‐grooming. In addition, A13 neurons increased their activity in response to various external stimuli and during natural self‐grooming episodes. Finally, monosynaptic retrograde tracing showed that the paraventricular hypothalamus represents one of the major upstream brain regions to A13 neurons. Taken together, these results reveal that A13 neurons are one of the brain sites that promote appetitive self‐grooming involving DA release to the PAG.
Adaptation of Fusarium Head Blight Pathogens to Changes in Agricultural Practices and Human Migration
Authors: Yang Meixin , Smit Sandra , de Ridder Dick , Feng Jie , Liu Taiguo , Xu Jinrong , van der Lee Theo A. J. , Zhang Hao , Chen Wanquan 
Published: August 2024

AbstractFusarium head blight (FHB) is one of the most destructive wheat diseases worldwide. To understand the impact of human migration and changes in agricultural practices on crop pathogens, here population genomic analysis with 245 representative strains from a collection of 4,427 field isolates of Fusarium asiaticum, the causal agent of FHB in Southern China is conducted. Three populations with distinct evolution trajectories are identifies over the last 10,000 years that can be correlated with historically documented changes in agricultural practices due to human migration caused by the Southern Expeditions during the Jin Dynasty. The gradual decrease of 3ADON‐producing isolates from north to south along with the population structure and spore dispersal patterns shows the long‐distance (>250 km) dispersal of F. asiaticum. These insights into population dynamics and evolutionary history of FHB pathogens are corroborated by a genome‐wide analysis with strains originating from Japan, South America, and the USA, confirming the adaptation of FHB pathogens to cropping systems and human migration.
Achieving Image Encryption Quantum Dot‐Functionalized Encryption Camera with Designed Films
Authors: Li Xue , Zhang Tao , Liu Mingriu , Fu Ying , Zhong Haizheng 
Published: August 2024

AbstractThe risk of information leaks increases as images become a crucial medium for information sharing. There is a great need to further develop the versatility of image encryption technology to protect confidential and sensitive information. Herein, using high spatial redundancy (strong correlation of neighboring pixels) of the image and the in situ encryption function of a quantum dot functionalized encryption camera, in situ image encryption is achieved by designing quantum dot films (size, color, and full width at half maximum) to modify the correlation and reduce spatial redundancy of the captured image during encryption processing. The correlation coefficients of simulated encrypted image closely apporach to 0. High‐quality decrypted images are achieved with a PSNR of more than 35 dB by a convolutional neural network‐based algorithm that meets the resolution requirements of human visual perception. Compared with the traditional image encryption algorithms, chaotic image encryption algorithms and neural network‐based encryption algorithms described previously, it provides a universal, efficient and effective in situ image encryption method.
Monocyte/Macrophage‐Mediated Transport of Dual‐Drug ZIF Nanoplatforms Synergized with Programmed Cell Death Protein‐1 Inhibitor Against Microsatellite‐Stable Colorectal Cancer
Authors: Ye Xietao , Liu Yuping , Wei Liangyin , Sun Yeyang , Zhang Xiaoran , Wang Hong , Guo Hong , Qin Xiaoying , Li Xiaoqi , Qu Ding , Huo Jiege , Chen Yan 
Published: August 2024

AbstractMicrosatellite‐stable colorectal cancer (MSS‐CRC) exhibits resistance to programmed cell death protein‐1 (PD‐1) therapy. Improving the infiltration and tumor recognition of cytotoxic T‐lymphocytes (CTLs) is a promising strategy, but it encounters huge challenges from drug delivery and mechanisms aspects. Here, a zeolitic imidazolate framework (ZIF) coated with apoptotic body membranes derived from MSS‐CRC cells is engineered for the co‐delivery of ginsenoside Rg1 (Rg1) and atractylenolide‐I (Att) to MSS‐CRC, named as Ab@Rg1/Att‐ZIF. This system is selectively engulfed by Ly‐6C+ monocytes during blood circulation and utilizes a “hitchhiking” mechanism to migrate toward the core of MSS‐CRC. Ab@Rg1/Att‐ZIF undergoes rapid disassembly in the tumor, released Rg1 promotes the processing and transportation of tumor antigens in dendritic cells (DCs), enhancing their maturation. Meanwhile, Att enhances the activity of the 26S proteasome complex in tumor cells, leading to increased expression of major histocompatibility complex class‐I (MHC‐I). These coordinated actions enhance the infiltration and recognition of CTLs in the center of MSS‐CRC, significantly improving the tumor inhibition of PD‐1 treatment from ≈5% to ≈69%. This innovative design, involving inflammation‐guided precise drug co‐delivery and a rational combination, achieves synergistic engineering of the tumor microenvironment, providing a novel strategy for successful PD‐1 treatment of MSS‐CRC.
Subsets of Nanometer Vesicles in the Fly Release Differential Fractions of Vesicular Serotonin Content during Exocytosis
Authors: Gu Chaoyi , Wang Ying , Yeoman Mark , Patel Bhavik Anil , Ewing Andrew G. 
Published: August 2024

AbstractSerotonin, a monoamine neurotransmitter, is important in both the central nervous system (CNS) and the peripheral nervous system. Malfunction of serotonin signaling leads to various disorders. We studied serotonin signaling from serotonergic neurons inside the ventral nerve cord of Drosophila melanogaster. Serotonergic neurons and stimulated release were visualized and achieved with mCherry and channelrhodopsin‐2 (an optogenetically transfected ion channel), respectively, and two electrochemical techniques quantified serotonin release and vesicular content. Mean vesicular serotonin content released during exocytosis from these neurons was 84 %, considerably higher than reported in previous studies regarding octopamine (4.5 %) and glutamate release (31 %). Serotonin content within all vesicles is uniformly changed when serotonin concentration is inhibited or enhanced. However, serotonin release exhibits two Gaussian distributions: higher frequency of small release events, and similar or slightly higher frequency of large events, resulting in differential release fractions ranging from partial (13–18 %) to full (100 %) release after treatment with agents to either enhance or diminish release. This is the first example of consistent full exocytotic release events we have observed in any system. We suggest one pool of vesicles can release significantly diverse fractions of transmitter load during exocytosis, a potentially novel pathway to regulate exocytosis and neuronal signaling.
Chiral Ligand‐Decorated Rhodium Nanoparticles Incorporated in Covalent Organic Framework for Asymmetric Catalysis
Authors: Yu Jiangtao , Yang Ge , Gao Ming‐Liang , Wang He , Jiang Hai‐Long 
Published: August 2024

AbstractWhile metal nanoparticles (NPs) have demonstrated their great potential in catalysis, introducing chiral microenvironment around metal NPs to achieve efficient conversion and high enantioselectivity remains a long‐standing challenge. In this work, tiny Rh NPs, modified by chiral diene ligands (Lx) bearing diverse functional groups, are incorporated into a covalent organic framework (COF) for the asymmetric 1,4‐addition reactions between arylboronic acids and nitroalkenes. Though Rh NPs hosted in the COF are inactive, decorating Rh NPs with Lx creates the active Rh−Lx interface and induces high activity. Moreover, chiral microenvironment modulation around Rh NPs by altering the groups on chiral diene ligands greatly optimizes the enantioselectivity (up to 95.6 % ee). Mechanistic investigations indicate that the formation of hydrogen‐bonding interaction between Lx and nitroalkenes plays critical roles in the resulting enantioselectivity. This work highlights the significance of chiral microenvironment modulation around metal NPs by chiral ligand decoration for heterogeneous asymmetric catalysis.
Carbon nitride/polyaniline/metal oxide composite system endows epoxy resin with reinforcements in the fire safety, thermal stability, and water resistance
Authors: Cui Jiahui , Ou Mingyu , Guan Haocun , Lian Richeng , Geng Yiwei , Zhao Zexuan , Li Rongjia , Liu Lei , Chen Xilei , Jiao Chuanmei 
Published: August 2024

AbstractReducing the fire risk of epoxy coatings has been a significant focus in the research of thermosetting resin materials. Various carbon nitride/polyaniline/metal oxide hybrids (CNPMOs) were synthesized using in‐situ oxidative polymerization and modified adsorption methods. Combustion analysis results indicated that CNPMOs effectively reduced the heat release of epoxy coatings during combustion. The epoxy coatings containing various CNPMOs (EFe, EY, and ETi) exhibited excellent smoke suppression and toxicity reduction properties. Furthermore, in comparison to the pure sample (E0) and reference sample (E1), the epoxy coatings EFe, EY, and ETi demonstrated improved thermal stability. In water resistance tests, the water absorption rates of EFe, EY, and ETi were significantly lower than that of E0. The CNPMOs enhanced the hydrophobicity of the epoxy coating to better protect the substrate in humid environments.
Bericht des Arbeitskreises „Baugruben“
Authors: Hettler Achim , Kinzler Steffen , Hackenbroch Wilfried , Haussmann Rainer , Herten Markus 
Published: August 2024

AbstractDer Arbeitskreis „Baugruben“ der Deutschen Gesellschaft für Geotechnik (DGGT) veröffentlicht seit 1968 regelmäßig Empfehlungen für die Berechnung, Bemessung und Konstruktion von Baugrubenumschließungen. Der vorliegende Beitrag gibt einen Überblick über die aktuellen Diskussionen im Arbeitskreis. Im vergangenen Jahr erfolgte hauptsächlich die Mitwirkung bei der Kommentierung der Entwürfe des neuen Eurocode 7. Ein weiterer Schwerpunkt war die Überarbeitung der EB 52 „Tragfähigkeit von Steifen“. Zusätzliche Themen waren eine Ergänzung des EC0 aus Sicht der Geotechnik und Bemessungsfragen zum Trägerbohlverbau mit Stützkeil.
Transcranial direct current stimulation over the right parietal cortex improves the depressive disorder: A preliminary study
Authors: Guo Xin , Zhou Qilin , Lu Yueying , Xu Zhexue , Wen Zhenye , Gu Ping , Tian Shujuan , Wang Yuping 
Published: August 2024

AbstractObjectiveThe right posterior parietal cortex is the core brain region of emotional processing and executive control network in the human brain, and the function of the right posterior parietal cortex is decreased in patients with major depressive disorder. This study aims to preliminarily investigate whether the excitation of the right posterior parietal cortex by transcranial direct current stimulation (tDCS) could improve their clinical symptoms.MethodsIn this study, 12 patients with major depressive disorder were given tDCS treatment at Xuanwu Hospital of Capital Medical University and the First Hospital of Hebei Medical University. The stimulating electrode (anode) was placed on the patients’ right parietal cortex, whereas the reference electrode (cathode) was placed on the patients’ left mastoid. The stimulation intensity was set as 2.0 mA. The patients with depressive disorder were treated for 20 min at a time twice a day for 14 consecutive days. The severity of the clinical symptoms was evaluated using the Hamilton Depression Rating Scale‐17 (HDRS‐17) and the Hamilton Anxiety Rating Scale (HARS) at before and right after treatment.ResultsThe HDRS‐17 scores of patients with depressive disorder decreased significantly following the tDCS treatment compared with those before treatment (p < .001). Further analysis revealed that the patients’ anxiety/somatization, cognitive deficit, retardation, and sleep disorder scores all decreased significantly after the tDCS treatment (p < .05), although there was no significant change in their weight. Moreover, the patients’ HARS scores decreased significantly after the tDCS treatment when compared with those before treatment (p < .01).ConclusionThe right parietal cortex may be another key stimulation targets to improving the efficacy of tDCS treatment to the patients with major depressive disorder.
Chemical Compositions and Antimicrobial and Mosquito Larvicidal Activities of the Leaf Essential Oils of Goniothalamus yunnanensis W.T.Wang and G. touranensis Ast: Experimental and In Silico Approaches
Authors: Ngoc Dai Do , Ngoc Sam Ly , Huong Le Thi , Huy Hung Nguyen , Xuan Ha Nguyen , Thi Tra Nguyen , Ngoc Linh Nguyen , The Son Ninh 
Published: August 2024

AbstractThe current research describes a phytochemical analysis and antimicrobial activity of essential oils extracted from the leaves of two Vietnamese Annonaceae species Goniothalamus yunnanensis W.T.Wang and G. touranensis Ast. By the GC‐FID/MS (gas chromatography‐flame ionization detection/mass spectrometry) analyses, sesquiterpene hydrocarbons accounted for the highest percentage of 68.22 % in G. yunnanensis leaf essential oil with bicyclogermacrene (31.03 %) and (E)‐caryophyllene (21.12 %) being the main compounds. G. touranensis leaf essential oil was dominated by monoterpene hydrocarbons (57.08 %) with p‐cymene (19.95 %) and α‐pinene (16.82 %) being the major compounds. By the microdilution broth susceptibility assay, two oil samples showed strong antibacterial effects on the Gram‐positive bacteria Enterococcus faecalis ATCC51299, Staphylococcus aureus ATCC29213, and Bacillus cereus ATCC11778 with the MIC values of 16–64 μg/mL. They also inhibited the growth of the yeast Candida albicans ATCC 60193 with the same MIC value of 128 μg/mL. From the vector‐based intervention approach, both oil samples showed strong mosquito larvicidal activity against four‐instar larvae of Aedes aegypti and Ae. albopictus with the 24 h LC50 values of 16.75–27.60 μg/mL and 24 h LC90 values of 24.31–46.18 μg/mL. Docking results indicated that bicyclogermacrene and p‐cymene exhibited the highest ΔG (binding affinity) values of −8.208 and −6.799 kcal/mol with the olfactory binding proteins (OBPs) of Ae. aegypti and Ae. albopictus, respectively.
Changes in Merkel cell oncoprotein antibodies after radiation therapy in curatively treated Merkel cell carcinoma and association with recurrence
Authors: Liu Kevin X. , Shin Kee‐Young , Thakuria Manisha , Schoenfeld Jonathan D. , Tishler Roy B. , Silk Ann W. , Yoon Charles H. , Fite Elliott , Margalit Danielle N. 
Published: August 2024

ABSTRACTBackgroundSerum antibodies to the Merkel oncoprotein (AMERK) are detectable in approximately 50% of patients with Merkel cell carcinoma (MCC) and can be used to monitor for recurrence. The objective of this study was to characterize AMERK levels in patients receiving curative‐intent radiation therapy (RT) for MCC and identify associations between AMERK and recurrence.MethodsThis was a retrospective study of patients with MCC who had baseline AMERK measurements before they received curative‐intent RT from 2010 to 2020. Event‐free survival (EFS) was calculated using the Kaplan–Meier method and Cox regression. The cumulative incidence of MCC‐related recurrence (CIMR) was analyzed with death as a competing risk and the Gray test.ResultsThe authors identified 88 patients who had baseline AMERK measurements, including 52 (59%) with detectable levels. AMERK positivity was associated with younger median age (67.8 vs. 72.0 years; p = .02) and tumor site (p = 0.02), with lower rates for those who had disease in the head/neck region (17.3% vs. 44.4%). EFS (71.3% vs. 60.4%; p = .30) and CIMR (24.4% vs. 39.6%; p = .23) were more favorable in AMERK‐positive patients. Two patients had recurrences in the RT field, and both were AMERK‐negative at baseline. The median time to AMERK nadir after RT was 11.2 months; and, in a 6‐month post‐RT landmark analysis, the proportion of patients who were AMERK‐positive who became negative or who had levels that decreased by ≥50% were not associated with EFS (87.1% vs. 85.0%; p = .90) or CIMR (12.9% vs. 15.0%; p = .62).ConclusionsPositive AMERK baseline levels were correlated with younger age at MCC diagnosis and nonhead and neck tumor location, possibly related to the distribution of viral etiology. A specific post‐RT AMERK decline correlating with EFS could not be identified.
SIoT identity management with the ability to preserve owner privacy and built‐in resistance to Sybil attacks
Authors: Dayyani Aboulfazl , Abbaspour Maghsoud 
Published: August 2024

SummaryThe Social Internet of Things (SIoT) allows for more efficient and intelligent communication between entities (humans and objects). Managing the digital identity of objects, protecting the owner's privacy, and resisting impersonation attacks are crucial challenges in SIoT. On the other hand, the classic centralized identity provider servers contain valuable information for hackers and malicious parties. Effective solutions can be presented using decentralized technologies such as blockchains. This paper proposes a decentralized identity management system for SIoT based on smart contract technology. This system drives object identity control; conversely, a zero‐knowledge‐based protocol and double‐spend prevention ideas are proposed for privacy preservation and Sybil attack resistance, respectively. The central idea is to implement self‐sovereign identity (SSI) so that even certifiers are not privy to object‐sensitive information. Additionally, it attempts to prevent the owner from creating Sybil objects using the web of trust method. The method's scalability and convergence can be proven by considering all acknowledgment nodes and different paths. This method was compared with the most novel available methods; the results from this comparison depict the scalability and effectiveness of the proposed method for large networks.
Profiling people with Parkinson's disease at risk of cognitive decline: Insights from PPMI and ICICLE‐PD data
Authors: Pourzinal Dana , Lawson Rachael A. , Yarnall Alison J. , Williams‐Gray Caroline H. , Barker Roger A. , Yang Jihyun , McMahon Katie L. , O'Sullivan John D. , Byrne Gerard J. , Dissanayaka Nadeeka N. 
Published: August 2024

AbstractIntroductionA subset of people with Parkinson's disease (PD) develop dementia faster than others. We aimed to profile PD cognitive subtypes at risk of dementia based on their rate of cognitive decline.MethodLatent class mixed models stratified subtypes in Parkinson's Progression Markers Initiative (PPMI) (N = 770) and ICICLE‐PD (N = 212) datasets based on their decline in the Montreal Cognitive Assessment over at least 4 years. Baseline demographic and cognitive data at diagnosis were compared between subtypes to determine their clinical profile.ResultsFour subtypes were identified: two with stable cognition, one with steady decline, and one with rapid decline. Performance on Judgement of Line Orientation, but not category fluency, was associated with a steady decline in the PPMI dataset, and deficits in category fluency, but not visuospatial function, were associated with a steady decline in the ICICLE‐PD dataset.DiscussionPeople with PD susceptible to cognitive decline demonstrate unique clinical profiles at diagnosis, although this differed between cohorts.Highlights
Four cognitive subtypes were revealed in two Parkinson's disease samples.
Unique profiles of cognitive impairment were related to cognitive decline.
Judgement of Line Orientation/category fluency predictive of steady decline.
Global deficits related to rapid cognitive decline and increased dementia risk.