bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Contribution of Symptom Incongruence to Prehospital Delay for Acute Myocardial Infarction Symptoms Among Jordanian Patients
Authors: Abed Mona A. , Khalil Amani A. , Moser Debra K. 
Published: April 2015

AbstractQualitative investigators have suggested that symptom incongruence, or a mismatch between symptoms that patients expect and those they experience in acute myocardial infarction (AMI), increases the time to hospitalization by affecting emotional, cognitive, and behavioral factors. No quantitative studies have been conducted that verify these relationships. We aimed to (a) examine the relationships among symptom incongruence, prehospital delay, anxiety level at onset of symptoms, perceived seriousness and importance of symptoms, source to which symptoms were attributed, and patients’ first response at symptom onset and (b) test the independent association of symptom incongruence to prehospital delay. Jordanian patients with AMI (n = 299) were interviewed using validated questionnaires, and medical records were reviewed to collect information on patients’ prehospital delay time, symptom incongruence, and response to AMI symptoms. Patients had low mean (7.5 ± 3.6) symptom incongruence scores (range 0–21 out of 24) and relatively short median prehospital delay (1.3 hours). Symptom incongruence was positively correlated with and independently predicted prehospital delay. Greater anxiety and greater perceived seriousness and importance of symptoms were associated with less incongruence and shorter prehospital delay. Patients who attributed their symptoms to a cardiac etiology had significantly shorter prehospital delay and less symptom incongruence than their counterparts. Patients who contacted the emergency medical service directly after symptom onset had shorter prehospital delay than their counterparts who did not, but did not differ on the level of symptom incongruence. Symptom incongruence may increase prehospital delay by complicating patients’ efforts to label and respond to AMI symptoms. © 2015 Wiley Periodicals, Inc.
Experimental analyses of an optimized shear load transfer in the circumferential joints of concrete segmental linings
Authors: Putke Thomas , Bohun Roksana , Mark Peter 
Published: April 2015

AbstractThe coupling of subsequent rings in the circumferential joints of tunnel lining systems is of particular interest in mechanized tunnelling and a controversial issue in discussions. On the one hand, interlocking systems such as “cam & pot” can be of use in limiting the lining's deformation. But on the other hand, unfavourable conditions often lead to repetitive and significant damage that decreases the tunnel's lifetime. This paper describes the experimental results of a three‐part optimization concept (structural analysis, topological optimization and experimental verification) that was tested for concrete linings using the example of the shear coupling mechanism. First, geometrical dependencies are analysed which reveal predominantly stronger cams than corresponding pots. Hence, pot bearing capacities are increased, transferring topological optimization results to reinforcement concepts featuring micro‐mesh reinforcement, steel fibre cocktails and rebars welded to anchor plates. The latter especially resulted in comparatively stronger pots along with considerably better ductility. Nevertheless, pots still represent the weaker part and are crucial for the design. Therefore, a concept with steel dowels and predefined static boundary conditions was tested. The results are characterized by a significantly lower scatter of bearing capacities accompanied by much better ductility.
TakoTsubo cardiomyopathy: unravelling the malignant consequences of a benign disease with cardiac magnetic resonance
Authors: Dastidar Amardeep Ghosh , Frontera Antonio , Palazzuoli Alberto , Bucciarelli-Ducci Chiara 
Published: April 2015

Abstract
TakoTsubo cardiomyopathy (TCM) is a unique type of reversible cardiomyopathy that is precipitated by a stressful emotional or physical event. The increasing incidence is due to the greater use of emergency coronary angiography, newer cardiac biomarkers together with more sensitive cardiac imaging techniques. Few case reports have documented how TCM can present with malignant arrhythmias such as torsades de pointes caused by the repolarisation abnormalities or QTc prolongation. Although TCM is usually considered a benign reversible condition, its associated arrhythmic risk is increasingly recognised. TCM often presents as an acute coronary syndrome with unobstructed coronary arteries at angiography. In this patient population, cardiac magnetic resonance (CMR) is a useful tool to establish a differential diagnosis, discriminating TCM from acute myocarditis and myocardial infarction with spontaneous recanalisation. CMR is becoming a promising new diagnostic modality in risk stratifying patients with potential higher arrhythmic risk.
Competing Risks Data Analysis with High-Dimensional Covariates: An Application in Bladder Cancer
Authors: Tapak Leili , Saidijam Massoud , Sadeghifar Majid , Poorolajal Jalal , Mahjub Hossein 
Published: April 2015

Abstract
Analysis of microarray data is associated with the methodological problems of high dimension and small sample size. Various methods have been used for variable selection in high-dimension and small sample size cases with a single survival endpoint. However, little effort has been directed toward addressing competing risks where there is more than one failure risks. This study compared three typical variable selection techniques including Lasso, elastic net, and likelihood-based boosting for high-dimensional time-to-event data with competing risks. The performance of these methods was evaluated via a simulation study by analyzing a real dataset related to bladder cancer patients using time-dependent receiver operator characteristic (ROC) curve and bootstrap .632+ prediction error curves. The elastic net penalization method was shown to outperform Lasso and boosting. Based on the elastic net, 33 genes out of 1381 genes related to bladder cancer were selected. By fitting to the Fine and Gray model, eight genes were highly significant (P  &lt; 0.001). Among them, expression of RTN4, SON, IGF1R, SNRPE, PTGR1, PLEK, and ETFDH was associated with a decrease in survival time, whereas SMARCAD1 expression was associated with an increase in survival time. This study indicates that the elastic net has a higher capacity than the Lasso and boosting for the prediction of survival time in bladder cancer patients. Moreover, genes selected by all methods improved the predictive power of the model based on only clinical variables, indicating the value of information contained in the microarray features.
Preoperative staging of rectal cancer with MRI: correlation with pathologic staging
Authors: Abreu Soraia Filipa Macado , Martins Sandra Fátima Fernandes 
Published: April 2015

Abstract
Introduction An accurate preoperative rectal cancer staging is crucial to the correct management of the disease. Despite great controversy around this issue, pelvic magnetic resonance (RM) is said to be the imagiologic standard modality. This work aimed to evaluate magnetic resonance accuracy in preoperative rectal cancer staging comparing with the anatomopathological results.
Methods We calculated sensibility, specificity, positive (VP positive) and negative (VP negative) predictive values for each T and N. We evaluated the concordance between both methods of staging using the Cohen weighted K (K
w), and through ROC curves, we evaluated magnetic resonance accuracy in rectal cancer staging.
Results 41 patients met the inclusion criteria. We achieved an efficacy of 43.9% for T and 61% for N staging. The respective sensibility, specificity, positive and negative predictive values are 33.3%, 94.7%, 33.3% and 94.7% for T1; 62.5%, 32%, 37.0% and 57.1% for T2; 31.8%, 79%, 63.6% and 50% for T3 and 27.8%, 87%, 62.5% and 60.6% for N. We obtained a poor concordance for T and N staging and the anatomopathological results. The ROC curves indicated that magnetic resonance is ineffective in rectal cancer staging.
Conclusion Magnetic resonance has a moderate efficacy in rectal cancer staging and the major difficulty is in differentiating T2 and T3.
Enterorrhagia due to pelvic hematoma after femoral catheterization
Authors: Silveira Júnior Sérgio , de Souza Kock Kaiser , Silvano Diego Machado , Soares Mariana , Delgado Daniel Rufato 
Published: April 2015

AbstractArterial puncture, better known as catheterization, has become an important diagnostic tool in recent years. For its realization, generally the option is the Seldinger technique, which is considered today the safest and most often used procedure. This technique allows the insertion of large-caliber or multiple-lumen catheters in the vessel. Arterial catheterization helps in several exams, for instance, mesenteric angiography and cardiac output assessment, and contributes in cineangiocoronariography procedures. We report the case of a 67-year-old male patient who was submitted to cineangiocoronariography and evolved with enterorrhagia due to pelvic hematoma. Throughout the patient's care, a conservative treatment was chosen. The progression of the patient was uneventful and then the patient was discharged. It is very hard to determine which arterial segment was injured; however, as the hematoma was located predominantly in the pelvic region, it is believed that an injury occurred at the internal iliac artery, or directly at the bifurcation of the common iliac artery. Furthermore, it is assumed that a catheter kinking occurred during its progression, due to any tortuosity or to the presence of an atheromatous plaque, thus favoring the occurrence of the more distal lesion, rather than the proximal one. We decided to report this case because of its high degree of rarity, with a scarce number of papers in the literature related to the topic. Thus, with the description of this report we believe that other medical teams will have facilitated their decision-making process, when facing a similar case.
Whole grain intake and its association with intakes of other foods, nutrients and markers of health in the National Diet and Nutrition Survey rolling programme 2008–11
Authors: Mann Kay D. , Pearce Mark S. , McKevith Brigid , Thielecke Frank , Seal Chris J. 
Published: April 2015

Epidemiological evidence suggests an inverse association between whole grain consumption and the risk of non-communicable diseases, such as CVD, type 2 diabetes, obesity and some cancers. A recent analysis of the National Diet and Nutrition Survey rolling programme (NDNS-RP) has shown lower intake of whole grain in the UK. It is important to understand whether the health benefits associated with whole grain intake are present at low levels of consumption. The present study aimed to investigate the association of whole grain intake with intakes of other foods, nutrients and markers of health (anthropometric and blood measures) in the NDNS-RP 2008–11, a representative dietary survey of UK households. A 4-d diet diary was completed by 3073 individuals. Anthropometric measures, blood pressure levels, and blood and urine samples were collected after diary completion. Individual whole grain intake was calculated with consumers categorised into tertiles of intake. Higher intake of whole grain was associated with significantly decreased leucocyte counts. Significantly higher concentrations of C-reactive protein were seen in adults in the lowest tertile of whole grain intake. No associations with the remaining health markers were seen, after adjustments for sex and age. Over 70 % of this population did not consume the minimum recommend intake associated with disease risk reduction, which may explain small variation across health markers. Nutrient intakes in consumers compared with non-consumers were closer to dietary reference values, such as higher intakes of fibre, Mg and Fe, and lower intakes of Na, suggesting that higher intake of whole grain is associated with improved diet quality.
Tracking year-to-year changes in intestinal nematode communities of rufous mouse lemurs (Microcebus rufus)
Authors: AIVELO TUOMAS , MEDLAR ALAN , LÖYTYNOJA ARI , LAAKKONEN JUHA , JERNVALL JUKKA 
Published: April 2015

SUMMARYWhile it is known that intestinal parasite communities vary in their composition over time, there is a lack of studies addressing how variation in component communities (between-hosts) manifests in infracommunities (within-host) during the host lifespan. In this study, we investigate the changes in the intestinal parasite infracommunities in wild-living rufous mouse lemurs (Microcebus rufus) from Ranomafana National Park in southeastern Madagascar from 2010 to 2012. We used high-throughput barcoding of the 18S rRNA gene to interrogate parasite community structure. Our results show that in these nematode communities, there were two frequently occurring putative species and four rarer putative species. All putative species were randomly distributed over host individuals and they did not occur in clear temporal patterns. For the individuals caught in at least two different years, there was high turnover of putative species and high variation in fecal egg counts. Our study shows that while there was remarkable variation in infracommunities over time, the component community was relatively stable. Nevertheless, the patterns of prevalence varied substantially between years in each component community.
Explaining deviations from the Stability and Growth Pact: power, ideology, economic need or diffusion?
Authors: Hansen Michael A. 
Published: April 2015

AbstractWhy do some countries deviate from European Union law? More specifically, why do countries violate the Stability and Growth Pact, which is a cornerstone piece of legislation for the shared economy? Is it that violators simply have no other choice due to economic need? Are the violators intentional deviators that are simply able to violate the Stability and Growth Pact because of their power in the European Union? This article answers these questions and identifies those factors that are most likely to impact a country’s deviation from the two main clauses of the Stability and Growth Pact. The major finding is that it is economic need, not a country’s relative power, governing ideology or diffusion, that has a large impact on which clause will be violated.
Semi-cores in imperial relations: The cases of Scotland and Norway
Authors: SKUMSRUD ANDERSEN MORTEN 
Published: April 2015

AbstractRecently, the field of International Relations has seen increased interest in international hierarchy, and also an upswing in the analytical study of imperial logics of rule. Nonetheless, existing structural models of empire focus on core-periphery dynamics, and so cannot explain polities that display elements of both core and periphery. Therefore, I offer the new concept of ‘semi-cores’. Semi-cores are a specific form of historical political associations whereby certain imperial provinces are different from the others in terms of the close relationships it maintains with the imperial metropolis. Semi-cores are different by virtue of being relatively similar. The conceptualisation of semi-cores is followed by a section illustrating its logic, examining the relatively unfamiliar cases of Scotland and Norway and their position within the Danish and British empires, respectively. Although being separate imperial provinces, these were tightly connected to an imperial core. This concept helps us better understand imperial logics, and in the process shows how cultural factors can be formalised into accounts of structural logics of rule, impacting our understanding of both historical and contemporary hierarchical international affairs.
Real-time observation of epitaxial graphene domain reorientation
Authors: Rogge Paul C. , Thürmer Konrad , Foster Michael E. , McCarty Kevin F. , Dubon Oscar D. , Bartelt Norman C. 
Published: April 2015

AbstractGraphene films grown by vapour deposition tend to be polycrystalline due to the nucleation and growth of islands with different in-plane orientations. Here, using low-energy electron microscopy, we find that micron-sized graphene islands on Ir(111) rotate to a preferred orientation during thermal annealing. We observe three alignment mechanisms: the simultaneous growth of aligned domains and dissolution of rotated domains, that is, ‘ripening’; domain boundary motion within islands; and continuous lattice rotation of entire domains. By measuring the relative growth velocity of domains during ripening, we estimate that the driving force for alignment is on the order of 0.1 meV per C atom and increases with rotation angle. A simple model of the orientation-dependent energy associated with the moiré corrugation of the graphene sheet due to local variations in the graphene–substrate interaction reproduces the results. This work suggests new strategies for improving the van der Waals epitaxy of 2D materials.
Universal structure of transmission eigenchannels inside opaque media
Authors: Davy Matthieu , Shi Zhou , Park Jongchul , Tian Chushun , Genack Azriel Z. 
Published: April 2015

AbstractAs the desire to explore opaque materials is ordinarily frustrated by multiple scattering of waves, attention has focused on the transmission matrix of the wave field. This matrix gives the fullest account of transmission and conductance and enables the control of the transmitted flux; however, it cannot address the fundamental issue of the spatial profile of eigenchannels of the transmission matrix inside the sample. Here we obtain a universal expression for the average disposition of energy of transmission eigenchannels within random diffusive systems in terms of auxiliary localization lengths determined by the corresponding transmission eigenvalues. The spatial profile of each eigenchannel is shown to be a solution of a generalized diffusion equation. These results reveal the rich structure of transmission eigenchannels and enable the control of the energy distribution inside random media.
Metabolite localization in living drosophila using High Resolution Magic Angle Spinning NMR
Authors: Sarou-Kanian Vincent , Joudiou Nicolas , Louat Fanny , Yon Maxime , Szeremeta Frédéric , Même Sandra , Massiot Dominique , Decoville Martine , Fayon Franck , Beloeil Jean-Claude 
Published: April 2015

AbstractWe have developed new methods enabling in vivo localization and identification of metabolites through their 1H NMR signatures, in a drosophila. Metabolic profiles in localized regions were obtained using HR-MAS Slice Localized Spectroscopy and Chemical Shift Imaging at high magnetic fields. These methods enabled measurement of metabolite contents in anatomic regions of the fly, demonstrated by a decrease in β-alanine signals in the thorax of flies showing muscle degeneration.
Office Paper Platform for Bioelectrochromic Detection of Electrochemically Active Bacteria using Tungsten Trioxide Nanoprobes
Authors: Marques A. C. , Santos L. , Costa M. N. , Dantas J. M. , Duarte P. , Gonçalves A. , Martins R. , Salgueiro C. A. , Fortunato E. 
Published: April 2015

AbstractElectrochemically active bacteria (EAB) have the capability to transfer electrons to cell exterior, a feature that is currently explored for important applications in bioremediation and biotechnology fields. However, the number of isolated and characterized EAB species is still very limited regarding their abundance in nature. Colorimetric detection has emerged recently as an attractive mean for fast identification and characterization of analytes based on the use of electrochromic materials. In this work, WO3 nanoparticles were synthesized by microwave assisted hydrothermal synthesis and used to impregnate non-treated regular office paper substrates. This allowed the production of a paper-based colorimetric sensor able to detect EAB in a simple, rapid, reliable, inexpensive and eco-friendly method. The developed platform was then tested with Geobacter sulfurreducens, as a proof of concept. G. sulfurreducens cells were detected at latent phase with an RGB ratio of 1.10 ± 0.04 and a response time of two hours.
Characterization of zinc uptake by mouse primary cultured astrocytes and microglia
Authors: Segawa Shohei , Tatsumi Nao , Ohishi Akihiro , Nishida Kentaro , Nagasawa Kazuki 
Published: April 2015

Abstract
To elucidate the regulatory mechanism for extracellular zinc in the CNS, we examined the zinc uptake characteristics in mouse astrocytes and microglia. Zinc was taken up into the two cell types time-dependently, and the cell-to-medium concentration (C/M) ratio in the initial uptake phase in astrocytes was significantly smaller than that in microglia, while in the steady state phase, there was no difference in their C/M ratios. In both astrocytes and microglia, the zinc uptake was mediated, at least in part, by high- and low-affinity systems. There were no differences for both in the Km values for zinc uptake between astrocytes and microglia, and those for the low-affinity system in both cell types were the same as that for mouse ZIP1 reported previously. On the other hand, the Vmax values for both systems were greater in microglia than in astrocytes. Among ZIP isoforms, expression of ZIP1 was high in astrocytes and microglia. Nickel, a competitive inhibitor of ZIP1, and ZIP1 knock-down decreased zinc uptake by both types of cells. Overall, it is demonstrated that astrocytes and microglia had a similar uptake system for zinc including ZIP1, and the differences found in their uptake profiles imply that they play different roles in the regulation of extracellular zinc to maintain brain homeostasis.
Generation of the antioxidant yellow pigment derived from 4-methylthio-3-butenyl isothiocyanate in salted radish roots (takuan-zuke)
Authors: Takahashi Asaka , Yamada Tsuyoshi , Uchiyama Yohei , Hayashi Satomi , Kumakura Kei , Takahashi Hitoe , Kimura Norihisa , Matsuoka Hiroki 
Published: April 2015

Abstract
2-[3-(2-Thioxopyrrolidin-3-ylidene)methyl]-tryptophan (TPMT) is a yellow pigment of salted radish roots (takuan-zuke) derived from 4-methylthio-3-butenyl isothiocyanate (MTBITC), the pungent component of radish roots. Here, we prepared salted radish and analyzed the behavior of the yellow pigment and related substances in the dehydration process and long-term salting process. All salted radish samples turned yellow, and their b* values increased with time and temperature. The salted radish that was sun-dried and pickled at room temperature turned the brightest yellow, and the generation of TPMT was clearly confirmed. These results indicate that tissue shrinkage due to dehydration, salting temperature, and pH play important roles in the yellowing of takuan-zuke.