bluuebunny/crossref_metadata_2025_split huggingface dataset:
El proceso de dirección integral de las organizaciones como un problema teórico, metodológico y práctico
Authors: Pacheco Espejel Arturo Andrés 
Published: February 2013

Résumé L’objectif central du présent travail est de décrire un modèle du processus de management des organisations (publiques, privées et sociales), basé sur une conceptualisation intégrale de l’organisation, entendue comme une entité sociale constituée par deux mondes (celui des « choses » et celui de l’infra-monde des « signifiés ») et de cinq dimensions (la technique, la stratégie, le social, le stucturel et l’histoire). Il s’agit aussi de présenter une méthodologie d’intervention organisationnelle destinée à l’encadrement de direction et les défis principaux pour son application concrète. Nous cherchons donc à envisager le processus de management de façon globale, intégrée, comme un problème à la fois théorique, méthodologique et pratique.
Vespula vulgaris(Hymenoptera: Vespidae) gynes use a sex pheromone to attract males
Authors: Brown Robert L. , El-Sayed Ashraf M. , Suckling David Maxwell , Stringer Lloyd D. , Beggs Jacqueline R. 
Published: February 2013

AbstractSex attraction studies were carried out to investigate the mate-finding behaviour of invasiveVespula vulgaris(Linnaeus) (Hymenoptera: Vespidae) wasps. Delta traps were baited with live, caged males, and gynes (virgin queens) ofV. vulgaristo determine whether either sex produced a long-range sex attractant. Traps baited with gynes caught 71 males, while the controls and live-male wasp baited traps did not catch gynes. Wind tunnel trials were performed to verify if the signal produced by the gynes was chemical in nature. First,V. vulgarismales were flown to live caged gynes, where more than half of the males tested flew upwind in a zigzagging pattern and made contact with caged gynes. Males were also flown to hexane rinses of gynes and flew upwind in a zigzagging pattern towards the gyne extract, although none made contact with the cotton roll stimulus. The results presented here demonstrate conclusively thatV. vulgarisgynes produce a sex pheromone.
β2-Adrenoreceptor Agonist Inhibits Antigen Cross-Presentation by Dendritic Cells
Authors: Hervé Julie , Dubreil Laurence , Tardif Virginie , Terme Mickael , Pogu Sylvie , Anegon Ignacio , Rozec Bertrand , Gauthier Chantal , Bach Jean-Marie , Blancou Philippe 
Published: February 2013

Abstract
Despite widespread usage of β-adrenergic receptor (AR) agonists and antagonists in current clinical practice, our understanding of their interactions with the immune system is surprisingly sparse. Among the AR expressed by dendritic cells (DC), β2-AR can modify in vitro cytokine release upon stimulation. Because DC play a pivotal role in CD8+ T cell immune responses, we examined the effects of β2-AR stimulation on MHC class I exogenous peptide presentation and cross-presentation capacities. We demonstrate that β2-AR agonist-exposed mature DC display a reduced ability to cross-present protein Ags while retaining their exogenous peptide presentation capability. This effect is mediated through the nonclassical inhibitory G (Gαi/0) protein. Moreover, inhibition of cross-presentation is neither due to reduced costimulatory molecule expression nor Ag uptake, but rather to impaired phagosomal Ag degradation. We observed a crosstalk between the TLR4 and β2-AR transduction pathways at the NF-κB level. In vivo, β2-AR agonist treatment of mice inhibits Ag protein cross-presentation to CD8+ T cells but preserves their exogenous MHC class I peptide presentation capability. These findings may explain some side effects on the immune system associated with stress or β-agonist treatment and pave the way for the development of new immunomodulatory strategies.
Programmed Downregulation of CCR6 Is Important for Establishment of Epidermal γδT Cells by Regulating Their Thymic Egress and Epidermal Location
Authors: Hu Shaomin , Xiong Na 
Published: February 2013

Abstract
The skin as the outmost epithelial tissue is under frequent physical, chemical, and biological assaults. To counter the assaults and maintain the local tissue homeostasis, the skin is stationed with various innate or innate-like lymphocytes such as γδT cells. Increasing evidence suggests that an intrathymically programmed process is involved in coordinated expression of multiple homing molecules on specific γδT cell subsets to direct their localization in different regions of the skin for the protective functions. However, detailed molecular events underlying the programmed skin distribution of specific γδT cell subsets are not fully understood. We report in this study that the temporally and spatially regulated downregulation of chemokine receptor CCR6 on fetal thymic Vγ3+ epidermal γδT precursors is involved in their thymic egress and proper localization in the epidermis. Failure of downregulation of CCR6 in the mature Vγ3+ epidermal γδT precursor cells due to the constitutive expression of transgenic CCR6 resulted in their abnormal accumulation in the fetal thymus and reduced numbers of the epidermal γδT cells. In addition, the transgenic expression of CCR6 on the Vγ3+ γδT cells also improperly increased their distribution in dermis of the skin. Those findings advanced our understanding of the molecular basis regulating the tissue specific distribution of various innate-like γδT cell lymphocytes in the skin.
C5a Receptor Signaling Prevents Folate Deficiency–Induced Neural Tube Defects in Mice
Authors: Denny Kerina J. , Coulthard Liam G. , Jeanes Angela , Lisgo Steven , Simmons David G. , Callaway Leonie K. , Wlodarczyk Bogdan , Finnell Richard H. , Woodruff Trent M. , Taylor Stephen M. 
Published: February 2013

Abstract
The complement system is involved in a range of diverse developmental processes, including cell survival, growth, differentiation, and regeneration. However, little is known about the role of complement in embryogenesis. In this study, we demonstrate a novel role for the canonical complement 5a receptor (C5aR) in the development of the mammalian neural tube under conditions of maternal dietary folic acid deficiency. Specifically, we found C5aR and C5 to be expressed throughout the period of neurulation in wild-type mice and localized the expression to the cephalic regions of the developing neural tube. C5aR was also found to be expressed in the neuroepithelium of early human embryos. Ablation of the C5ar1 gene or the administration of a specific C5aR peptide antagonist to folic acid–deficient pregnant mice resulted in a high prevalence of severe anterior neural tube defect-associated congenital malformations. These findings provide a new and compelling insight into the role of the complement system during mammalian embryonic development.
Energy Policy Act of 2005: Pseudo-Fed for Transmission Congestion
Authors: Obrecht Alexander K. 
Published: February 2013

Increasing federal involvement in the wholesale electricity market, and the ever-important emphasis on renewable energy resources, exposed the inadequacies of the existing transmission infrastructure. The Energy Policy Act of 2005 (EPAct 2005) attempted to address the transmission problems butfailed to adequately consolidate federal power over transmission siting. The resulting atmosphere presents an unsustainable dichotomy in which federal involvement encourages generation dependent upon transmission access, while state control over transmission siting impedes the necessary investment and capital improvement. Despite the efforts of EPAct 2005, a coherent and effective national energy policy remains unobtainable without the ability to incentivize generation and guarantee access to transmission by facilitating its development across state lines.This note proceeds in two sections. First, the background section provides a brief history of federally mandated deregulation in the wholesale electricity market. A brief summary of EPAct 2005 then explains Congress's attempt to encourage transmission investment by allowing limited federal jurisdiction over the siting process. Second, the note analyzes the current pressures exerted on the transmission grid by renewable energy and inadequate state siting processes. The analysis then addresses the judicial interpretations of EPAct 2005 and how the United States Courts of Appeals delayed federal jurisdiction over transmission siting for the foreseeable future.
Establishing genetic diagnosis of intellectual disability in children: diagnostic yield of various genetic approaches
Authors: Kalibataitė Irma , Rutkauskas Vilius , Preikšaitienė Eglė , Kučinskas Vaidutis 
Published: February 2013

Background. The aim of our investigation was to examine aetiology of intellectual disability / developmental delay (ID / DD) in children referred to the Centre for Medical Genetics at the Vilnius University Hospital Santariskiu Clinics during 2009 and to evaluate the diagnostic yield of current genetic approaches.
Materials and methods. In a retrospective investigation, medical records of 217 patients younger than 18 years of age were reviewed with a focus on the family history and pedigree, personal history, physical examination, imaging and laboratory diagnostics. Patients with established genetic diagnosis were compared with cases without identified disorders. Aetiological structure of all cases was explored, as well as factors influencing the diagnosis of genetic predisposition and the yielding of the genetic methods for investigation of patients with ID or DD available in 2009.
Results. Genetic diagnosis was established for 88 (40.5%) patients. The diagnostic yielding of conventional karyotyping was 18%, molecular karyotyping 12.4%, metabolic testing 4.1%, FISH 2.3%, molecular genetics 0.9%, in 2.8% of patients the fetal alcohol syndrome was diagnosed.
Conclusions. Currently the most effective are conventional karyotyping and molecular karyotyping techniques, showing that chromosomal alterations are the most common cause of ID / DD. Mostly the diagnosis is established in severe cases of ID / DD with congenital anomalies and dysmorphic features. Metabolic testing is especially effective if suggestive clinical features of metabolic disorders are present. The low yielding of molecular genetics methods indicates the need of their integration into diagnostics of ID / DD in Lithuania.
La pratique des jeux traditionnels du Nord de la France
Authors: Vigne Mickaël , Joncheray Hélène 
Published: February 2013

Nous proposons le résultat d’un travail de plusieurs années mené autour de la pratique des jeux traditionnels dans l’espace linguistique picard (ELP) dans lequel les individus parlent un patois nommé « le picard ». L’objectif de ce travail fut de démontrer que le jeu constitue le miroir de la société dans laquelle il est pratiqué. Cette étude repose sur une comparaison intraculturelle établie à partir de différents critères ludiques. À travers le décryptage des pratiques motrices, nous exposons comment l’expression et l’affirmation des pratiques ludiques traditionnelles des joueurs s’inscrivent en tant que techniques du corps et façonnent le paysage patrimonial. Le décodage de la logique interne de 108 jeux traditionnels montre combien les pratiques ludiques traditionnelles s’affirment comme élément du patrimoine et attribut de distinction identitaire et culturelle. De fait, le jeu constitue un agent et un témoin de la société. Les résultats montrent que la fonction sociale des jeux traditionnels est fondamentale parce qu’elle constitue un élément unificateur pour les individus et demeure fédératrice en participant au renforcement de l’identité régionale. Ainsi, le jeu, et notamment le jeu traditionnel, témoigne de la richesse de l’identité culturelle d’un espace géographique. Cette perspective est mise en lumière à partir d’une comparaison avec certaines caractéristiques de la logique interne des jeux traditionnels du Nord et certains jeux du Canada.
Joseph-Thomas LeBlanc : la chanson de tradition orale au pied de la lettre
Authors: Savard Louis-Martin 
Published: February 2013

Entre 1938 et 1941, le journaliste acadien Joseph-Thomas LeBlanc (1899-1943) a fait publier 87 chroniques sur la chanson de tradition orale dans les pages de La Voix d’Évangéline. Sur le plan de la méthode ethnographique, plutôt que de parcourir les paroisses à la recherche de chanteurs, il correspond avec ses informateurs par le biais de son journal. À la même époque, il entretient également des relations épistolaires avec Marius Barbeau et Luc Lacourcière. C’est à la faveur de tous ces échanges écrits qu’il met en place ses chroniques et qu’il établit les versions des chansons qu’il publie. À partir de sa chronique consacrée à « La complainte de saint Alexis », cet article s’intéresse au travail pionnier de ce folkloriste aujourd’hui méconnu.
« Un renversement complet de la perspective ». Le catalogue du conte français à l’épreuve du terrain
Authors: Bru Josiane 
Published: February 2013

Prenant la suite de Paul Delarue décédé au moment de la publication du premier volume de son catalogue raisonné du conte populaire français, Marie-Louise Tenèze rédigea le second volume, clôturant ainsi la section des Contes merveilleux. Avant d’entreprendre celle des Contes d’animaux, elle mena sur le plateau d’Aubrac, au sud du Massif central, une enquête de littérature orale qui constitue le moment charnière de sa recherche. Nous avons voulu ici retracer ce parcours très riche et peu connu qui, plaçant désormais l’origine du conte dans le conteur lui-même, la conduit au-delà de la collecte des récits à dresser à l’écoute de ses interlocuteurs le « profil narratif » de cette région. Permettant l’élaboration de nouveaux concepts, ce déplacement du regard du conte vers les conteurs constitue, selon sa propre expression, « un renversement complet de la perspective » sur les contes de tradition orale, jusque-là abordés à partir de leur écriture et du point de vue de leur contenu.
Solid Waste Management Practices in Vigan City, Ilocos Sur, Philippines
Authors: Bajet, Jr. Manuel A. , Arce Gilbert R. , Soria Jimmy R. , Bermio Joussie B. , Paz Crizzle B. , Bajet Junel Bryan 
Published: February 2013

Solid waste management must be implemented consistently and effectively. The study aimed to assess the implementation of Solid Waste Management Program of Vigan City Province of Ilocos, Philippines. Specifically, it focused on identifying its solid waste recovery facility, type of wastes and its practices segregation, collection, disposal and utilization of wastes.Solid waste management practices such as on segregation was religiously followed by all constituents however, hazardous waste were treated in accordance to existing laws of the DENR and DOH. Collected wastes were segregated at the recovery site. Utilization of wastes includes production of organic fertilizer from compostable wastes, collected plastic containers were processed into plastic tables/monoblocks, cellophane were used as a cotton substitute for pillows, used as material for making souvenir items while paper waste were converted into paper pulp which can use as cooking fuel. Scrap iron and metals collected were sold by and spent for the maintenance of the recovery facilities. Produce organic fertilizers were given for free to poor farmers and sold at a minimal amount to those who could afford to pay through the Department of Agriculture. Monoblocks were utilized at the Day Care Centers of the City. Collected plastics cellophane for pillows and for souvenir items was given to poor families as their livelihood project. Keywords - Ecology, Solid Waste Management practices, descriptive, Vigan City, Philippines
Polymer Grafting by Inkjet Printing: A Direct Chemical Writing Toolset
Authors: Garcia Alexandre , Hanifi Nassim , Jousselme Bruno , Jégou Pascale , Palacin Serge , Viel Pascal , Berthelot Thomas 
Published: February 2013

AbstractAmong all the patterning techniques, inkjet printing has lately become a reliable technique at micrometer scale to produce localized modifications on material surfaces. Printing of polymer on material surface however leads to adsorbed patterns with poor adhesion. To overcome this drawback, a new process combining for the first time inkjet printing and an efficient covalent polymer grafting method was developed. This latter method is based on a photo‐assisted reduction of aryldiazonium salt/acrylate monomer ink, derived from the already published GraftFast process. In order to demonstrate its versatility, this new localized polymer grafting process is here combined as an example with the ligand induced electroless plating (LIEP) process to obtain metal interconnects onto flexible and transparent substrates with excellent mechanical and electrical properties for applications in flexible electronics devices.
Intracellular Staphylococcus aureus: the Trojan horse of recalcitrant chronic rhinosinusitis?
Authors: Tan Neil C.‐W. , Foreman Andrew , Jardeleza Camille , Douglas Richard , Vreugde Sarah , Wormald Peter‐John 
Published: February 2013

BackgroundDespite recent evidence suggesting that Staphylococcus aureus exists within the sinonasal epithelium of chronic rhinosinusitis (CRS) patients, certain questions remain. The intracellular environment may provide a protective niche for pathogenic bacteria to evade host immunity and yet provide a reservoir for reinfection. To date, no studies have examined the impact of this bacterial phenotype; therefore, this study was designed to evaluate the role of intracellular S. aureus on postsurgical outcomes.MethodsThis study included 51 patients undergoing endoscopic sinus surgery (ESS) for medically‐recalcitrant CRS. Sinonasal mucosa harvested at the time of surgery was dually stained with fluorescent molecular probes and imaged using confocal scanning laser microscopy for biofilm and intracellular status. Patients were followed in their early and late postoperative course for evidence of ongoing disease and signs of clinical relapse.ResultsIntracellular S. aureus was identified in 20 of 51 (39%) patients, and all were associated with surface biofilm. Biofilm alone was found in 16 of 51 (31%) patients and 15 of 51 (29%) patients had no evidence of S. aureus. Intracellular positive patients had a significantly higher risk of late clinical and microbiological relapse (p = 0.014). In this study, biofilm status without coexisting intracellular bacteria did not appear to impact on outcomes.ConclusionClinical and microbiological relapse of disease following ESS is significantly associated with intracellular S. aureus. Evidence suggests that this disease association is independent to surface biofilm status. Intracellular bacteria should be taken into consideration when designing novel treatment strategies to lessen the chance of reinfection.
Sinonasal rhabdomyosarcoma: prognostic factors and treatment outcomes
Authors: Thompson Christopher F. , Kim Brandon J. , Lai Chi , Grogan Tristan , Elashoff David , St. John Maie A. , Wang Marilene B. 
Published: February 2013

BackgroundDespite the improvement in survival of pediatric patients with rhabdomyosarcoma, the outcome of patients with sinonasal rhabdomyosarcoma is poor and has not significantly changed. Since few institutions have extensive experience with sinonasal rhabdomyosarcoma in children and adults, our objective was to determine prognostic factors and treatment outcomes for this rare malignancy.MethodsA retrospective review was performed of consecutive patients with sinonasal rhabdomyosarcoma treated at our institution from 1992 to 2012. Kaplan‐Meier estimates and the log‐rank test were performed to determine factors associated with disease recurrence and disease‐specific survival.ResultsInitial remission was achieved in 12 of the 16 patients. Age younger than 18 years (n = 9) was a positive prognostic factor, as there were no recurrences (p < 0.01) and no deaths (p < 0.01). The alveolar subtype was a poor prognostic factor, as 4 of the 5 patients with this histology died of disease (p < 0.01), and both patients with initial remission developed recurrence (p < 0.01). Presentation with later tumor‐node‐metastasis classification of malignant tumors (TNM) stage was also significant for poorer survival, as 2 of the 3 patients with stage IV died of disease (p = 0.05). Patient sex and treatment modality were not significant.ConclusionAlthough the sinonasal region is an unfavorable site for rhabdomyosarcomas, in our series patients younger than 18 years and those with embryonal or botryoid subtypes responded very well to current multimodality treatment. However, a poor prognostic trend is evident in patients with sinonasal alveolar rhabdomyosarcomas, as they appear to present more often with regional and distant metastases, have increased recurrence, and decreased survival.
Molecular mechanisms of curcumin action: Signal transduction
Authors: Shehzad Adeeb , Lee Young Sup 
Published: February 2013

AbstractChemoprevention represents one of the most highly effective anti‐cancer strategies and is accompanied by minimal secondary effects as compared to conventional chemotherapies. Many new anti‐inflammatory and anti‐cancer drug candidates have been derived from chemical scaffolds engineered from natural products discovered just a few decades ago. This approach is widely utilized in drug discovery in order to produce novel molecular entities with enhanced drug activities mediated through various signal transduction pathways for the treatment of different diseases. Curcumin, a polyphenolic derivative of turmeric, is a naturally occurring compound isolated from Curcuma longa that suppresses and inverts carcinogenesis via multifaceted molecular targets. Several reports have demonstrated that curcumin inhibits animal and human cancers, suggesting that it may serve as a chemopreventive agent. Numerous in vitro and in vivo experimental models have also revealed that curcumin regulates several molecules in cell signal transduction pathway including NF‐κB, Akt, MAPK, p53, Nrf2, Notch‐1, JAK/STAT, β‐catenin, and AMPK. Modulation of cell signaling pathways through the pleiotropic effects of curcumin likely activate cell death signals and induce apoptosis in cancer cells, thereby inhibiting the progression of disease. This article provides insights into the natural chemopreventive role of curcumin via cellular transduction pathways and provides an in depth assessment of its physiological activities in the management of diseases. © 2013 BioFactors, 39(1):27–36, 2013
A screening approach reveals the influence of mineral coating morphology on human mesenchymal stem cell differentiation
Authors: Choi Siyoung , Murphy William L. 
Published: February 2013

Abstract“Biomimetic” inorganic coating on biomaterials has been an active area of research with the aim of providing bioactive surfaces that can regulate cell behavior. Previous studies have demonstrated that human mesenchymal stem cell (hMSC) behavior is differentially regulated by the physical and chemical properties of inorganic mineral coatings, indicating that modulation of mineral properties is potentially important in regulating hMSC behavior. However, the lack of an efficient experimental context, in which to study stem cell behavior on inorganic substrates, has made it difficult to systematically study the effects of specific mineral coating parameters on hMSC behavior. In this study, we developed an efficient experimental platform to screen for the effects of mineral coating morphology on hMSC expansion and differentiation. hMSC expansion on mineral coatings was regulated by the micro‐scale morphology of these coatings, with greater expansion on small granule‐like coatings when compared to plate‐like or net‐like coatings. In contrast, hMSC osteogenic differentiation was inversely correlated with cell expansion on mineral coatings indicating that mineral coating morphology was a key parameter that regulates hMSC differentiation. The effect of mineral coating morphology on hMSC behavior underlines the utility of this inorganic screening platform to identify optimal coatings for medical devices and bone tissue engineering applications.