bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin D Regulates Fatty Acid Composition in Subcutaneous Adipose Tissue Through Elovl3
Authors: Ji Lijuan , Gupta Mihir , Feldman Brian J. 
Published: October 2015

Abstract
Fatty acids (FAs) are a major energy source in the body. White adipose tissue (WAT) is a primary site where FAs are stored as triacylglycerols. Brown adipose tissue also stores and recruits FAs as a carbon source for uncoupled β-oxidation during thermogenesis. The deletion of the vitamin D nuclear hormone receptor (VDR) gene in mice (VDRKO) results in a lean WAT phenotype with increased levels of expression of the brown adipose tissue marker Ucp1 in the WAT. However, the impact of vitamin D/VDR on FA composition in WAT has not been explored in detail. To address this question, we examined the FA composition of sc and visceral white adipose depots of VDRKO mice. We found that the levels of a subset of saturated and monounsaturated FAs of C18-C24 are specifically increased in the sc adipose depot in VDRKO mice. We revealed that a specific elongase enzyme (Elovl3), which has an important role in brown fat biology, is directly regulated by VDR and likely contributes to the altered FA composition in VDRKO mice. We also demonstrate that Elovl3 is regulated by vitamin D in vivo and tissue specifically in the sc WAT depot. We discovered that regulation of Elovl3 expression is mediated by ligand-dependent VDR occupancy of a negative-response element in the promoter proximal region of the Elovl3 gene. These data suggest that vitamin D/VDR tissue specifically modulates FA composition in sc WAT through direct regulation of Elovl3 expression.
Using the MIUU Model for Prediction of Mean Wind Speed at Low Height
Authors: Olauson Jon , Samuelsson Jonatan , Bergström Hans , Bergkvist Mikael 
Published: October 2015

This paper presents an evaluation of using the MIUU mesoscale model to predict mean wind speed at 10 meters above ground. This was done by comparing the model output to 128 meteorological measurements in Sweden. Although some terrain-dependent bias was seen, the model worked surprisingly well. Mean absolute error (MAE) was 0.58 m/s or 0.52 m/s if a few measurements taken in highly complex terrain were excluded. By using a multiple regression model, taking into account the terrain at site, the latter value was lowered to 0.39 m/s. The model described in this paper can be useful for a first evaluation of the wind conditions for small-scale wind power or when measurements are not feasible.
A Criterion Space Search Algorithm for Biobjective Mixed Integer Programming: The Triangle Splitting Method
Authors: Boland Natashia , Charkhgard Hadi , Savelsbergh Martin 
Published: October 2015

We present the first criterion space search algorithm, the triangle splitting method, for finding all nondominated points of a biobjective mixed integer program. The algorithm is relatively easy to implement and converges quickly to the complete set of nondominated points. The algorithm maintains, at any point in time, a diverse set of nondominated points, and is thus ideally suited for fast approximation of the nondominated frontier. An extensive computational study demonstrates the efficacy of the triangle splitting method. Data, as supplemental material, are available at http://dx.doi.org/10.1287/ijoc.2015.0646 .
A national survey by the SDMA: use of evidence in nursing practice
Authors: Brassington N. J. , Muldoon J. , Hill C. , Arrowsmith M. 
Published: October 2015

Objective: Recently, two surveys were conducted by the Surgical Dressing Manufacturers Association (SDMA) to investigate the evidence required to support wound care products. These showed very clearly that industry provides significant amounts of evidence in a way that appears to meet the expectations of relevant health professionals and their practice for treating patients with wounds. The responses of health professionals refuted the opinion that evidence may be lacking for wound care products. Hopefully, the results of these surveys also add weight to the argument that the Cochrane Review approach is not always the most appropriate for wound care—where the comorbidities of patients are variable and often plural.
Improving Students’ Skills in Translation through Students-Teams Achievement Division (STAD) Technique
Authors: Ahmad Syarwan 
Published: October 2015

This classroom action rresearch was aimed at improving students’ skills in translating at the English Department of the State Islamic University (UIN) Ar-Rarniry Banda Aceh by using the Student-Teams Achievement Division (STAD) Technique. Throughout the entire cycles, students worked in groups of 4-5 persons to plan and write their translations. The study showed that the average score of pre- test (66) increased dramatically to reach 86, and moved up a little higher (87) after the second cycle. It is recommended that STAD Cooperative Technique be implemented in teaching translation courses. Key words: Teaching translation; STAD; UIN Aceh.Copyright © 2015 by Al-Ta'lim All right reserved
Islam and Environment: Education Perspective
Authors: Fathil Mohd. , Saam Zulfan , Sukendi Sukendi , Nizar Syamsul 
Published: October 2015

A Muslim views that nature belongs to God and human beings must show that they are grateful by learning how to use and manage it well so that it can provide benefits to the mankind. Exploiting nature taught by Islam is based on the utilization of responsibility that provides benefits not only for its content but also its intact and sustainable opportunities to cultivate and for rehabilitation or to help speed up its recovery. Humans are required to have certain characters towards nature, which means dealing with nature by maintaining sustainability. Therefore, God gives cues to enable people to control themselves in exploitation of the natural resources which causes defection that can harm and even destroy human life. For that reason, Islam forbids destructing or harming the environment ranging from very small actions and trivial such as prohibiting throwing human faces under a fruit tree, in the river, on the road, or in the shelter areas. Prophet Muhammad (PBUH) is also very concerned about the preservation of wildlife, as described in the Hadith narrated by Abu Dawood. Even Prophet never reprimanded one of his companions during the Hijrah period to take the chicks out of the nest. Similarly, Islam cares about the environment created by God which human beings are mandated to maintain nature properly and responsibly. Keywords: Concept of Islam, the environment, education.Copyright © 2015 by Al-Ta'lim All right reserved
The Education in Local Islamic Culture of Maulid Nabi Tradition: a Case Study in Nurul Yaqin Ringan-Ringan Pakandangan Padang Pariaman Boarding School
Authors: Rivauzi Ahmad 
Published: October 2015

A wave of globalization encourages intercultural contact more rapidly. This led to an integration between the new values with the old ones that occur outside as well as inside the organization. This encourages the fusion of process and haziness value, even the erosion of the original values of the previously sacred and the identity of a nation. This paper focus on the tradition of Maulid Nabi as one of the local Islamic traditions in Nurul Yaqin Ringan-Ringan Pakandangan Padang Pariaman Boarding School. The tradition of the Maulid Nabi (Prophet's birthday) is a particular religious practice as a result of the grounding the normative teachings of Islam into reality. Education through local Islamic culture is needed by a community in order to have resilience and ability to acquire the significance life such as found in the Nurul Yaqin Ringan-Ringan Pakandangan Pariaman Boarding School’s community. Keyword : Education, Local Islamic culture, and Warnings Birth of the ProphetCopyright © 2015 by Al-Ta'lim All right reserved
Integrating occupancy models and structural equation models to understand species occurrence
Authors: Joseph Maxwell B. , Preston, Daniel L. , Johnson Pieter T. J. 
Published: October 2015

AbstractUnderstanding the drivers of species occurrence is a fundamental goal in basic and applied ecology. Occupancy models have emerged as a popular approach for inferring species occurrence because they account for problems associated with imperfect detection in field surveys. Current models, however, are limited because they assume covariates are independent (i.e., indirect effects do not occur). Here, we combined structural equation and occupancy models to investigate complex influences on species occurrence while accounting for imperfect detection. These two methods are inherently compatible because they both provide means to make inference on latent or unobserved quantities based on observed data. Our models evaluated the direct and indirect roles of cattle grazing, water chemistry, vegetation, nonnative fishes, and pond permanence on the occurrence of six pond‐breeding amphibians, two of which are threatened: the California tiger salamander (Ambystoma californiense) and the California red‐legged frog (Rana draytonii). While cattle had strong effects on pond vegetation and water chemistry, their overall effects on amphibian occurrence were small compared to the consistently negative effects of nonnative fish. Fish strongly reduced occurrence probabilities for four of five native amphibians, including both species of conservation concern. These results could help to identify drivers of amphibian declines and to prioritize strategies for amphibian conservation. More generally, this approach facilitates a more mechanistic representation of ideas about the causes of species distributions in space and time. As shown here, occupancy modeling and structural equation modeling are readily combined, and bring rich sets of techniques that may provide unique theoretical and applied insights into basic ecological questions.
Genetic diversity affects the strength of population regulation in a marine fish
Authors: Johnson D. W. , Freiwald J. , Bernardi G. 
Published: October 2015

AbstractVariation is an essential feature of biological populations, yet much of ecological theory treats individuals as though they are identical. This simplifying assumption is often justified by the perception that variation among individuals does not have significant effects on the dynamics of whole populations. However, this perception may be skewed by a historic focus on studying single populations. A true evaluation of the extent to which among‐individual variation affects the dynamics of populations requires the study of multiple populations. In this study, we examined variation in the dynamics of populations of a live‐bearing, marine fish (black surfperch; Embiotoca jacksoni). In collaboration with an organization of citizen scientists (Reef Check California), we were able to examine the dynamics of eight populations that were distributed throughout ~700 km of coastline, a distance that encompasses much of this species’ range. We hypothesized that genetic variation within a local population would be related to the intensity of competition and to the strength of population regulation. To test this hypothesis, we examined whether genetic diversity (measured by the diversity of mitochondrial DNA haplotypes) was related to the strength of population regulation. Low‐diversity populations experienced strong density dependence in population growth rates and population sizes were regulated much more tightly than they were in high‐diversity populations. Mechanisms that contributed to this pattern include links between genetic diversity, habitat use, and spatial crowding. On average, low‐diversity populations used less of the available habitat and exhibited greater spatial clustering (and more intense competition) for a given level of density (measured at the scale of the reef). Although the populations we studied also varied with respect to exogenous characteristics (habitat complexity, densities of predators, and interspecific competitors), none of these characteristics was significantly related to the strength of population regulation. In contrast, an endogenous characteristic of the population (genetic diversity) explained 77% of the variation in the strength of population regulation (95% CI: 27–94%). Our results suggest that the genetic and phenotypic composition of populations can play a major role in their dynamics.
Waterflood Sweep Pattern Monitoring Using 4D Seismic in Windri Area, Asri Basin, Southeast Sumatra, Indonesia
Authors: Widiatmo Reza , Nugroho Pranowo , Sunarta Julius 
Published: October 2015

Abstract
Reservoir characterization in Windri field is complicated by complex lithology and difficulties in predicting changes in fluid distribution. 33–4 Sand body is interpreted as complex compartmentalized channel and part of water flood project associated with distributary channels, mouth bars and delta front shoals. Seismic amplitude mapping at the Base Upper Gita horizon reveals a system of meandering channels. In 2000 and 2004, 4D seismic data set was acquired and processed to take advantage of seismic AVO effects. The base line 1991 seismic data set was reprocessed in parallel. The primary reason for the monitor data set was to observe the reservoir pressure depletion state around a water-flooding project. Detection of 33–4 sandstone reservoir is feasible based on interpretation of AVO P, G, P*G, P(30°) attributes. Fluid replacement model created into three scenarios (oil, water, gas) to predict the hydrocarbon saturation. Integrated time lapse 4D seismic by using map differences in seismic response has been conducted for monitoring pressure decrease and subsequent water flooding sweep patterns. Windri area divided into 6 sweep patterns area to make improved connectivity analysis.
AVO attributes using intercept (P), gradient (G), P*G, and P(30°) has been done to determine of 33–4 sand. Feasibility study on AVO analysis has been applied by using fluid replacement model on the well data. A more advanced interpretation of the expanded AVO analysis for 33–4 sand has been done by using simultaneous inversion and 4D time lapse seismic. Practically, this method is used to map differences in seismic response over time attributable to production related processes, especially amplitude response which directly interpreted as replacement of oil by dissolved gas, and also suggest re-pressurizing the reservoir. Reservoir characterization using 4D simultaneous inversion enhances interpretative resolution and reduces uncertainty sand and fluid prediction. Integrated analysis of time lapse 4D seismic has been well implemented for increasing infill and injector success ratio, as well as predominating pressure degradation in Windri field. This comprehensive study is essential for understanding of complex lithology, monitoring pressure decrease and subsequent water flooding sweep patterns in 33–4 sandstones reservoir. Knowing the concept of depositional setting, facies and reservoir behavior to be applied in the waterflood project is crucial to optimize the production.
The Current State and Future Direction of IT Audit: Challenges and Opportunities
Authors: Dzuranin Ann C. , Mălăescu Irina 
Published: October 2015

ABSTRACT:
Embracing the spirit of the Pathways Commission's focus of enhancing the value of practitioner/educator exchanges, the inaugural Journal of Information Systems Conference (JISC) brought together 30 academic researchers and 15 practitioners to discuss the current state and the future direction of information technology (IT) audit research and practice. Panelists, comprised of practitioners from government, public accounting, and industry, provided insight into current IT audit issues. The first panel discussed the role of IT auditors in helping organizations meet compliance requirements and ensuring that information systems add value to the organization. The second panel addressed the future of IT audit in a world of advanced analytics and emerging technologies. Although the panels addressed separate topics, common themes emerged from the discussions. Issues facing the IT audit profession as a result of the increasing volume of data available, coupled with changing technology and increasing regulatory requirements, underscored much of the discussion. Big Data, compliance, and emerging technology issues were addressed from both internal audit and external audit perspectives. This commentary provides a review and synthesis of the information presented during panel discussions at the conference and suggests potential research questions.
The Association between Information Technology Investments and Audit Risk
Authors: Han Shipeng , Rezaee Zabihollah , Xue Ling , Zhang Joseph H. 
Published: October 2015

ABSTRACT
Advances in information technology (IT) have changed the way that companies conduct business, prepare their financial statements, and have their financial statements audited. On one hand, IT decreases audit risk by improving operation and internal control effectiveness, which may decrease inherent and internal control risk. On the other hand, the complexity of IT introduces unconventional risks for companies and their auditors, especially by creating challenges for auditors when auditing the effectiveness of internal controls and detecting accounting irregularities. Thus, the relationship between clients' IT investments and audit risk deserves research attention. Using IT data of U.S. firms from 2000 to 2009, we find that IT investments are positively related to audit fees (and abnormal audit fees), the probability of auditors' issuance of a going-concern opinion, and the likelihood of auditors' Type II errors. Furthermore, we find that auditor tenure moderates the relationship between IT investments and audit fees due to the learning effect.
Twelve-Week Treatment With Liraglutide as Add-on to Insulin in Normal-Weight Patients With Poorly Controlled Type 1 Diabetes: A Randomized, Placebo-Controlled, Double-Blind Parallel Study
Authors: Frandsen Christian S. , Dejgaard Thomas F. , Holst Jens J. , Andersen Henrik U. , Thorsteinsson Birger , Madsbad Sten 
Published: October 2015

OBJECTIVE
This study investigated the efficacy and safety of once-daily liraglutide 1.2 mg versus placebo as add-on to insulin treatment in normal-weight patients with poorly controlled type 1 diabetes.

RESEARCH DESIGN AND METHODS
In a randomized (1:1), double-blind, placebo-controlled design, 40 patients with type 1 diabetes (HbA1c ≥8% [64 mmol/mol]) received once-daily liraglutide 1.2 mg or placebo for 12 weeks. Continuous glucose monitoring was performed before and at the end of treatment. The primary end point was change in HbA1c. Secondary end points included change in insulin dose, weight, glycemic excursions, heart rate, and blood pressure.

RESULTS
Baseline HbA1c was similar in the liraglutide and placebo group (8.8 ± 0.2 and 8.7 ± 0.1% [72.5 ± 2.2 and 71.8 ± 1.5 mmol/mol]). Change in HbA1c from baseline was −0.6 ± 0.2% (−6.22 ± 1.71 mmol/mol) with liraglutide and −0.5 ± 0.2% (−5.56 ± 1.67 mmol/mol) with placebo (P = 0.62). Variation in glycemic excursions did not change in either group. Change in body weight was −3.13 ± 0.58 and +1.12 ± 0.42 kg (P &lt; 0.0001) with liraglutide and placebo, respectively. The bolus insulin dose decreased in liraglutide-treated patients and did not change with placebo treatment (4.0 ± 1.3 vs. 0.0 ± 1.0 IU, P = 0.02). Heart rate increased within the liraglutide group (P = 0.04) but not compared with placebo, whereas mean systolic blood pressure decreased compared with placebo (between-group difference 3.21 mmHg [95% CI −8.31 to 1.90], P = 0.04). Liraglutide was more frequently associated with gastrointestinal adverse effects. The incidence of hypoglycemia did not differ between groups.

CONCLUSIONS
Liraglutide significantly reduces body weight and insulin requirements but has no additional effect on HbA1c in normal-weight patients with type 1 diabetes inadequately controlled on insulin alone.
Impact of Type 2 Diabetes and Postmenopausal Hormone Therapy on Incidence of Cognitive Impairment in Older Women
Authors: Espeland Mark A. , Brinton Roberta Diaz , Hugenschmidt Christina , Manson JoAnn E. , Craft Suzanne , Yaffe Kristine , Weitlauf Julie , Vaughan Leslie , Johnson Karen C. , Padula Claudia B. , Jackson Rebecca D. , Resnick Susan M. ,   for the WHIMS Study Group
Published: October 2015

OBJECTIVE
In older women, higher levels of estrogen may exacerbate the increased risk for cognitive impairment conveyed by diabetes. We examined whether the effect of postmenopausal hormone therapy (HT) on cognitive impairment incidence differs depending on type 2 diabetes.

RESEARCH DESIGN AND METHODS
The Women’s Health Initiative (WHI) randomized clinical trials assigned women to HT (0.625 mg/day conjugated equine estrogens with or without [i.e., unopposed] 2.5 mg/day medroxyprogesterone acetate) or matching placebo for an average of 4.7–5.9 years. A total of 7,233 women, aged 65–80 years, were classified according to type 2 diabetes status and followed for probable dementia and cognitive impairment (mild cognitive impairment or dementia).

RESULTS
Through a maximum of 18 years of follow-up, women with diabetes had increased risk of probable dementia (hazard ratio [HR] 1.54 [95% CI 1.16–2.06]) and cognitive impairment (HR 1.83 [1.50–2.23]). The combination of diabetes and random assignment to HT increased their risk of dementia (HR 2.12 [1.47–3.06]) and cognitive impairment (HR 2.20 [1.70–2.87]) compared with women without these conditions, interaction P = 0.09 and P = 0.08. These interactions appeared to be limited to women assigned to unopposed conjugated equine estrogens.

CONCLUSIONS
These analyses provide additional support to a prior report that higher levels of estrogen may exacerbate risks that type 2 diabetes poses for cognitive function in older women. The role estrogen plays in suppressing non–glucose-based energy sources in the brain may explain this interaction.
Effects of Autogenic Drainage on Sputum Recovery and Pulmonary Function in People with Cystic Fibrosis: A Systematic Review
Authors: Morgan Kimbly , Osterling Kristin , Gilbert Robert , Dechman Gail 
Published: October 2015

Purpose: To determine the effects of short- and long-term use of autogenic drainage (AD) on pulmonary function and sputum recovery in people with cystic fibrosis (CF). Methods: The authors conducted a systematic review of randomized and quasi-randomized clinical trials in which participants were people with CF who use AD as their sole airway clearance technique. Results: Searches in 4 databases and secondary sources using 5 key terms yielded 735 articles, of which 58 contained the terms autogenic drainage and cystic fibrosis. Ultimately, 4 studies, 2 of which were long term, were included. All measured forced expiratory volume in 1 second (FEV1) and found no change. The long-term studies were underpowered to detect change in FEV1; however, the short-term studies found a clinically significant sputum yield (≥4 g). Conclusion: AD has been shown to produce clinically significant sputum yields in a limited number of investigations. The effect of AD on the function of the pulmonary system remains uncertain, and questions have emerged regarding the appropriateness of FEV1 as a valid measure of airway clearance from peripheral lung regions. Further consideration should be given to the use of FEV1 as a primary measure of the effect of AD.