bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transdisciplinary approach to the characterisation and current status of Spanish karstic lakes on gypsum
Authors: Morant Daniel , Camacho-Santamans Alba , Hidalgo Rafael , Camacho Antonio 
Published: August 2024

AbstractKarstic lakes on gypsum are a very peculiar type of ecosystem declared as a Habitat Type of Community Interest (Type 3190) by the European Habitats Directive. They are usually small lakes but often displaying a high relative depth, located in active gypsum karst areas, with a high saturation of Ca2+ and SO42− in its waters. These lakes can usually stratify from spring to early autumn when the depth is high enough, then a sulphide-rich anoxic hypolimnion can develop in deep layers. So far, neither a comprehensive scientific definition of their ecological characteristics nor an exhaustive catalogue of their occurrence in a particular territory are available. This paper delves on their biotic and abiotic features needed for their identification as an ecosystem type. A proper methodology was also designed and applied for the evaluation of their conservation status, with the definition of reference values and assessment methods following the criteria of the Habitats Directive. The Spanish karstic lakes on gypsum (THCI 3190) were here identified, statistically representative sites were selected, and spatial GIS methods and multimetric indices were applied to assess the range, area, structure and function, and future prospects of this Habitat Type, as requested for the reporting according to Article 17 of the Habitats Directive. Results showed a favourable conservation status of this habitat type in the Alpine and Atlantic regions of Spain, but unfavourable-inadequate status in the Mediterranean, due to the pressures and impacts acting on some specific sites. A critical analysis of the methodologies and the values obtained for its conservation status was carried out.
Unveiling the Triple Diffusion Bioconvective Applications for Couple Stress Nanofluid Due To an Oscillating Regime with Variable Thermal Features
Authors: Khan Sami Ullah , Adnan  , Riaz Arshad , Ramesh Katta , Bhatti M. M. 
Published: August 2024

AbstractThermal engineering and industrial processes see various multidisciplinary applications due to the enhanced thermal performances of nanomaterials. The nanomaterials preserve a profound breakthrough in enhancing the heat transfer phenomenon. The objective of the current investigation is to address the thermal applications of couples-stress nanofluid in the presence of triple diffusion effects. The analysis is subject to the bioconvective significance of the suspension of microbes. The viscosity and thermal conductivity of a couple stress fluids are assumed to be variable. Moreover, we endorse linear thermal radiation effects and approach the problem with an effective Prandtl number. The source of flow is an oscillatory, porous stretching surface. Based on suggested flow assumptions, the model is represented via nonlinear couple partial differential equations (PDEs). We employ the homotopy analysis scheme to forecast the analytical simulations. The physical outcomes for the involved parameters are observed for the modeled problem. Various aspects based on the deduced results are claimed. Based on the performed analysis, it is observed that the magnitude of skin friction decreases due to variations in the couple-stress fluid parameter. The heat increases with the modified Dufour number and variable thermal conductivity coefficient. Furthermore, an increasing behavior of nanoparticle solutal concentration has been observed due to the Dufour-Lewis number.
Ionic liquid-based transparent membrane-coupled human lung epithelium-on-a-chip demonstrating PM0.5 pollution effect under breathing mechanostress
Authors: Kaya Bilgesu , Yesil-Celiktas Ozlem 
Published: August 2024

AbstractThe plausibility of human exposure to particulate matter (PM) has witnessed an increase within the last several years. PM of different sizes has been discovered in the atmosphere given the role of dust transport in weather and climate composition. As a regulator, the lung epithelium orchestrates the innate response to local damage. Herein, we developed a lung epithelium-on-a-chip platform consisting of easily moldable polydimethylsiloxane layers along with a thin, flexible, and transparent ionic liquid-based poly(hydroxyethyl) methacrylate gel membrane. The epithelium was formed through the culture of human lung epithelial cells (Calu-3) on this membrane. The mechanical stress at the air–liquid interface during inhalation/exhalation was recapitulated using an Arduino-based servo motor system, which applied a uniaxial tensile strength from the two sides of the chip with 10% strain and a frequency of 0.2 Hz. Subsequently, the administration of silica nanoparticles (PM0.5) with an average size of 463 nm to the on-chip platform under static, dynamic, and dynamic + mechanical stress (DMS) conditions demonstrated the effect of environmental pollutants on lung epithelium. The viability and release of lactate dehydrogenase were determined along with proinflammatory response through the quantification of tumor necrosis factor-α, which indicated alterations in the epithelium.
Graphic abstract
Remote pulmonary pathology diagnosis using a handheld device for acquiring lung sounds at the mouth: a proof of concept study
Authors: Menachemi Doron M. , Brodsky Tom , Shimelis Kasa , Abu Kartouma Muhammad , Hochstadt Aviram 
Published: August 2024

Abstract
Introduction
Obtaining relevant information about respiratory conditions is a unique challenge in the rapidly growing field of telehealth. While auscultation using a stethoscope remains the first-line method in primary care, it is not a practical solution in a home setting, as it requires the presence of both a skilled caregiver and experienced interpreter online. We conducted a proofofconcept study of a simple selfcheck thermometer-like device (OmnySense®), which acquires auscultatory data through a microphone in the head of the device.

Objectives
To have a concept of proof that home handled simplified device can asure a remote opion in telemedicine enhancing prompt and ease way to diagnose lung pathologies.

Methods
We assessed the agreement between subjective evaluations of lung sounds using the device and those using a digital stethoscope for the presence of crackles and/or wheezes. A total of 385 recordings from 13 patients admitted to the internal department were blindly, individually, and randomly assessed by three experienced physicians. The intra-modality agreement for crackles between evaluators was moderate for both the device and the stethoscope, with kappa statistics of 0.44 and 0.6 for the device and stethoscope, respectively, for the detection of wheezing and 0.46 and 0.4, respectively, for the crackles. The intermodality agreement was moderate for wheezes, with a kappa of 0.53, and was substantial for crackles, with a kappa of 0.71. Comparing the ability of crackles to diagnose pulmonary findings by imaging showed comparable sensitivity and specificity for both modalities.

Conclusions
Our findings suggest that the diagnostic performance of OmnySense’s selfoperating device is similar to that of physician interpretation of digital stethoscope recordings; thus, OmnySense has the potential to become a useful tool in the remote assessment of respiratory conditions and pathologies.
Density functional theory study of two-dimensional hybrid organic-inorganic perovskites: frontier level alignment and chirality-induced spin splitting
Authors: Song Ruyi , Zhao Rundong 
Published: August 2024

AbstractPerovskites are a class of semiconductors initially recognized for their exceptional efficiency in solar cell applications. Subsequent research has revealed their diverse and attractive optoelectronic properties. Over the last decades, molecule-level engineering attempts toward the original three-dimensional (“3D”) perovskites have led to the emergence of two-dimensional (“2D”) layered crystals and introduced extensive compositional, structural, and electronic tunability through the incorporation of various organic cations to form hybrid perovskite systems. Consequently, we concentrated on the theoretical investigation of innovative and complex 2D hybrid organic-inorganic perovskites using density functional theory (DFT). A DFT-based simulation protocol has been developed, enabling the efficient simulation of hybrid perovskite systems and providing accurate explanations and predictions of various experimental phenomena. This account article summarizes the recent in-depth DFT study of the structural, electronic, and spin-related properties of 2D hybrid organic-inorganic perovskites.
Langzeitfolgen einer Intensivtherapie
Authors: Wiegele Marion , Hermann Martina , Kimberger Oliver , Schaden Eva , Tiboldi Akos 
Published: August 2024

ZusammenfassungDas Post-Intensive Care Syndrom (PICS) beschreibt Beeinträchtigungen der physischen, kognitiven oder psychischen Funktionen, die nach einem Intensivaufenthalt erstmals oder verstärkt auftreten. Diese Langzeitfolgen stellen eine Herausforderung für den Alltag Betroffener und deren Familien, aber auch für das Gesundheitssystem und den Arbeitsmarkt dar. Die strukturierte Nachsorge durch multiprofessionelle Teams in Form von Spezialambulanzen bzw. spezifischen Rehabilitationsprogrammen verbessert die Lebensqualität ehemaliger Intensivpatient:innen. In Österreich gibt es bisher keine flächendeckende Nachsorge für Betroffene. Ziel dieses Artikels ist die Sensibilisierung der Behandlungsteams und das Aufzeigen der Vorteile einer strukturierten Nachsorge mit Anbindung an das Krankenhaus.
Affordable generic digital twins for existing building environment management and an onsite deployment
Authors: Li Jingming , Wang Jiaoju 
Published: August 2024

AbstractThe energy consumption during the operation and maintenance phase of buildings is huge. As the built-up area in China increases, the demand for energy conservation in existing buildings has become a key focus of its dual carbon policy. Intelligent operation and maintenance based on digital twins is an emerging means to reduce carbon emissions from buildings, but it faces some problems in the process of promotion. Complete digital and intelligent transformation requires significant investment and has certain requirements for project parties and operation and maintenance teams. Small businesses or individual households have relatively simple requirements for intelligent operation and maintenance scenarios and do not require complete digital twins. To address the above issues, this article uses an affordable universal digital twin framework to provide a digital solution for intelligent operation and maintenance of existing buildings. This solution allows networking communication between devices and uses IoT modules to monitor and control the environment. This digital twinning model can reduce the measurement and control of energy-consuming end devices without on-site transformation and has rich scalability. This article uses the solution to deploy an office at a university in Henan Province and specifically measures the power consumption of displays, indoor environment, and air conditioning. According to the needs, it expands the space occupation, fans, air handlers, lights, and other end devices of the digital twin. The digital twin accurately presents the energy consumption of the office during extreme weather conditions, which has an auxiliary role in promoting digital twins in the region and optimizing energy consumption in existing buildings.
Intraosseous schwannoma mimicking periapical radiolucency of mandible
Authors: Vijayalakshmi Kondajji Ramachandra , Jain Vanshika , Mehta Sushma , Mamthashri Veeranjaneyalu , Kavya Bettadahalli Thimmaiah 
Published: August 2024

AbstractIntraosseous schwannoma is a rare entity with less than 1% reported cases. Having predilection for posterior mandible, they are clinically slow growing and asymptomatic until they manifest as intra or extra oral swelling with or without nerve paraesthesia. 38-year-old female patient reported with chief complaint of swelling in lower left back teeth region gradually increasing to current size in last three months. With history of recent extraction, and well-defined, uniformly radiolucent lesion having sclerotic margins and buccal cortical breach, a provisional diagnosis of residual cyst of 36 was considered. However, incisional biopsy revealed it to be schwannoma, thereby changing the course of management. Absence of conclusive clinical signs and symptoms and non-specific radiographic features make intraosseous schwannoma a challenging diagnosis. It is therefore important that careful attention be paid to adjoining radiographic structures and possible nerve involvement.
Sediment Provenance Along the Middle Miocene‐Pleistocene Nankai Subduction Zone From Sediment Transport to Accretion: Implications for Stratigraphy in the Accretionary Prism
Authors: Cornard P. H. , Dawson H. L. , Pickering K. T. 
Published: August 2024

AbstractBased on U‐Pb dating of zircon crystals and petrographic analysis, this study provides new insights into the paleogeographic and accretion evolution along SW Japan. Our data are consistent with an older submarine fan identified from drilling in the Shikoku Basin (Kyushu Fan ∼14.7–12.2 Ma), having a mixed sand provenance from the paleo‐Yangtze/Yellow rivers and the Shimanto Belt, and the younger Zenisu Fan (∼9.2–7.6 Ma), which is mainly sourced from the Shimanto Belt and the Izu‐Bonin/Honshu arc collision. Our results are in agreement with the hypothesis of very oblique subduction or strike‐slip motion between the northern Shikoku Basin and mainland Honshu from ∼12.2 to 9.2 Ma, after which essentially orthogonal subduction occurred after ∼8 Ma. The two main sandbodies drilled at IODP Site C0002 within the inner Nankai Accretionary Prism have similar petrographic signatures to those of the Zenisu and Kyushu submarine fans in the Shikoku Basin. The incorporation of the Shikoku Basin deposits most likely resulted from the seaward propagation of in‐sequence thrusts forming an outer accretionary wedge. The incorporation of the Kyushu Fan into the inner accretionary prism implies that the décollement was located in the hemipelagic interval beneath the Kyushu Fan at least until ∼2 Ma, whereas it is now located in the hemipelagic intervals below the Zenisu Fan. Such shifts in décollement location are most likely related to changes in physical properties of the hemipelagic interval due to significant compaction and diagenesis during subduction.
2021 Heatwave Over Western North America: Structural Uncertainty and Internal Variability in GCM Projections of Humidex and Temperature Extremes
Authors: Jeong Dae Il , Yu Bin , Cannon Alex J. 
Published: August 2024

AbstractThe 2021 heatwave over Western North America (WNA) led to record‐breaking air temperatures and human‐perceived heat stress (humidex) values. The event was accompanied by drier conditions driven by prolonged atmospheric blocking. During the heatwave, the maximum 6‐day means of humidex and temperature (HX‐6 and TX‐6) exhibited larger anomalies (6.70 and 5.57°C) compared to the 95th percentiles (HX95 and TX95) (4.12 and 3.73°C), relative to 1981–2021 extended summer (June‐September) averages. Extreme indices of humidex show faster and larger increases than those of temperature, reflecting the nonlinear positive relationship between humidex and temperature. Future projections from a multi‐model ensemble of 19 Coupled Model Intercomparison Project Phase six (CMIP6) Global Climate Models (GCMs) clearly show an increase in humidex and temperature extremes, especially under intermediate and high emissions scenarios. Humidex indices (HX‐6 and HX95) show faster and larger increases than temperature indices (TX‐6 and TX95) for the same future years and global warming levels. Controlling for differences in GCM climate sensitivity to greenhouse gas forcing yields robust projections at various global warming levels, reducing the ranges of projected changes from the multi‐model ensemble. At 3.0°C global warming from pre‐industrial, the multi‐model ensemble projects occurrences of HX‐6, TX‐6, HX95, and TX95 over WNA that exceed 2021 levels to occur every 3.9, 1.7, 1.4, and 2.2 years, respectively, increasing to almost annually at 4.0°C.
Sensitivity of Australian Rainfall to Driving SST Data Sets in a Variable‐Resolution Global Atmospheric Model
Authors: Liu Ying Lung , Alexander Lisa V. , Evans Jason P. , Thatcher Marcus 
Published: August 2024

AbstractIn this study, we employ the Conformal Cubic Atmospheric Model (CCAM), a variable‐resolution global atmospheric model, driven by two distinct sea surface temperature (SST) data sets: the 0.25° Optimum Interpolation Sea Surface Temperature (CCAM_OISST) version 2.1 and the 2° Extended Reconstruction SSTs Version 5 (CCAM_ERSST5). Model performance is assessed using a benchmarking framework, revealing good agreement between both simulations and the climatological rainfall spatial pattern, seasonality, and annual trends obtained from the Australian Gridded Climate Data (AGCD). Notably, wet biases are identified in both simulations, with CCAM_OISST displaying a more pronounced bias. Furthermore, we have examined CCAM’s ability to capture El Niño‐Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD) correlations with rainfall during Austral spring (SON) utilizing a novel hit rate metric. Results indicate that only CCAM_OISST successfully replicates observed SON ENSO‐ and IOD‐rainfall correlations, achieving hit rates of 86.6% and 87.5%, respectively, compared to 52.7% and 41.8% for CCAM_ERSST5. Large SST differences are found surrounding the Australian coastline between OISST and ERSST5 (termed the “Coastal Effect”). Differences can be induced by the spatial interpolation error due to the discrepancy between model and driving SST. An additional CCAM experiment, employing OISST with SST masked by ERSST5 in 5° proximity to the Australian continent, underscores the “Coastal Effect” has a significant impact on IOD‐Australian rainfall simulations. In contrast, its influence on ENSO‐Australian rainfall is limited. Therefore, simulations of IOD‐Australian rainfall teleconnection are sensitive to local SST representation along coastlines, probably dependent on the spatial resolution of driving SST.
Transient Aseismic Vertical Deformation Across the Steeply‐Dipping Pisia‐Skinos Normal Fault (Gulf of Corinth, Greece)
Authors: Mildon Zoë K. , Diercks Manuel , Roberts Gerald P. , Faure Walker Joanna P. , Ganas Athanassios , Papanikolaou Ioannis , Sakas Vassilis , Robertson Jenni , Sgambato Claudia , Mitchell Sam 
Published: August 2024

AbstractGeodetically‐derived deformation rates are sometimes used to infer seismic hazard, implicitly assuming that short‐term (annual‐decadal) deformation is representative of longer‐term deformation. This is despite geological observations indicating that deformation/slip rates are variable over a range of timescales. Using geodetic data from 2016 to 2021, we observe an up to 7‐fold increase in vertical deformation rate in mid‐2019 across the Pisia‐Skinos normal fault in Greece. We hypothesize that this deformation is aseismic as there is no temporally correlated increase in the earthquake activity (M > 1). We explore four possible physical mechanisms, and our preferred hypothesis is that the transient deformation is caused by centimeter‐scale slip in the upper 5 km of the Pisia fault zone. This is the first observation of shallow tectonic (i.e., not related to human activities) aseismic deformation on a normal fault globally. Our results suggest that continental normal faults can exhibit variable deformation over shorter timescales than previously observed, and thus care should be taken when utilizing geodetic rates to quantify seismic hazard.
Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives
Authors: Shi Xiaoli , Wang Xinyi , Yao Wentao , Shi Dongmin , Shao Xihuan , Lu Zhengqing , Chai Yue , Song Jinhua , Tang Weiwei , Wang Xuehao 
Published: August 2024

AbstractMetastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-associated mortality. Despite its significance, the mechanisms governing metastasis are not fully elucidated. Contemporary findings in the domain of cancer biology have shed light on the molecular aspects of this intricate process. Tumor cells undergoing invasion engage with other cellular entities and proteins en route to their destination. Insights into these engagements have enhanced our comprehension of the principles directing the movement and adaptability of metastatic cells. The tumor microenvironment plays a pivotal role in facilitating the invasion and proliferation of cancer cells by enabling tumor cells to navigate through stromal barriers. Such attributes are influenced by genetic and epigenetic changes occurring in the tumor cells and their surrounding milieu. A profound understanding of the metastatic process’s biological mechanisms is indispensable for devising efficacious therapeutic strategies. This review delves into recent developments concerning metastasis-associated genes, important signaling pathways, tumor microenvironment, metabolic processes, peripheral immunity, and mechanical forces and cancer metastasis. In addition, we combine recent advances with a particular emphasis on the prospect of developing effective interventions including the most popular cancer immunotherapies and nanotechnology to combat metastasis. We have also identified the limitations of current research on tumor metastasis, encompassing drug resistance, restricted animal models, inadequate biomarkers and early detection methods, as well as heterogeneity among others. It is anticipated that this comprehensive review will significantly contribute to the advancement of cancer metastasis research.
A novel interface for cortical columnar neuromodulation with multipoint infrared neural stimulation
Authors: Tian Feiyan , Zhang Ying , Schriver Kenneth E. , Hu Jia Ming , Roe Anna Wang 
Published: August 2024

AbstractCutting edge advances in electrical visual cortical prosthetics have evoked perception of shapes, motion, and letters in the blind. Here, we present an alternative optical approach using pulsed infrared neural stimulation. To interface with dense arrays of cortical columns with submillimeter spatial precision, both linear array and 100-fiber bundle array optical fiber interfaces were devised. We deliver infrared stimulation through these arrays in anesthetized cat visual cortex and monitor effects by optical imaging in contralateral visual cortex. Infrared neural stimulation modulation of response to ongoing visual oriented gratings produce enhanced responses in orientation-matched domains and suppressed responses in non-matched domains, consistent with a known higher order integration mediated by callosal inputs. Controls include dynamically applied speeds, directions and patterns of multipoint stimulation. This provides groundwork for a distinct type of prosthetic targeted to maps of visual cortical columns.