bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determinants of Advertising Effectiveness: The Development of an International Advertising Elasticity Database and a Meta-Analysis
Authors: Henningsen Sina , Heuke Rebecca , Clement Michel 
Published: March 2014

AbstractIncreasing demand for marketing accountability requires an efficient allocation of marketing expenditures. Managers who know the elasticity of their marketing instruments can allocate their budgets optimally. Meta-analyses offer a basis for deriving benchmark elasticities for advertising. Although they provide a variety of valuable insights, a major shortcoming of prior meta-analyses is that they report only generalized results as the disaggregated raw data are not made available. This problem is highly relevant because coding of empirical studies, at least to a certain extent, involves subjective judgment. For this reason, meta-studies would be more valuable if researchers and practitioners had access to disaggregated data allowing them to conduct further analyses of individual, e.g., product-level-specific, interests. We are the first to address this gap by providing (1) an advertising elasticity database (AED) and (2) empirical generalizations about advertising elasticities and their determinants. Our findings indicate that the average current-period advertising elasticity is 0.09, which is substantially smaller than the value 0f 0.12 that was recently reported by Sethuraman, Tellis, and Briesch (2011). Furthermore, our meta-analysis reveals a wide range of significant determinants of advertising elasticity. For example, we find that advertising elasticities are higher (i) for hedonic and experience goods than for other goods; (ii) for new than for established goods; (iii) when advertising is measured in gross rating points (GRP) instead of absolute terms; and (iv) when the lagged dependent or lagged advertising variable is omitted.
Product configuration, ambidexterity and firm performance in the context of industrial equipment manufacturing
Authors: Salvador Fabrizio , Chandrasekaran Aravind , Sohail Tashfeen 
Published: March 2014

AbstractThe practice of configuring products to individual customer orders has found application in a variety of industry contexts, but little is known about the specific capabilities that firms develop to successfully compete when offering configurable products. Our research begins to fill this gap in the context of industrial equipment manufacturing. Drawing from the ambidexterity literature, we argue that firms have to balance dual goals of reducing variation and promoting variation in their product configuration activities by fostering two distinct firm‐level capabilities: product configuration effectiveness (PCE) and product configuration intelligence (PCI). Specifically, we hypothesize that the simultaneous presence of PCE and PCI—that is, product configuration ambidexterity (PCA)—drives superior firm responsiveness and, indirectly firm sales and operating margin. However, we also contend that responsiveness gains through PCA can diminish with product complexity and can increase operating cost. We test these hypotheses by collecting both primary and secondary data from a sample of 108 European industrial equipment manufacturing firms. Results from our analyses indicate that PCA has an indirect effect through responsiveness on sales and operating cost but not on operating margin, with this effect diminishing with product complexity. Taken together, our results suggest that investment in developing PCA may represent a conundrum for industrial equipment manufacturing firms, because it translates into market but not financial advantages, and it is intertwined with product design decisions. We conclude this study with a discussion of the findings for theory and practice.
Mean structure of one-dimensional unstable detonations with friction
Authors: Sow Aliou , Chinnayya Ashwin , Hadjadj Abdellah 
Published: March 2014

AbstractThis investigation deals with the study of the mean structure of a mildly unstable non-ideal detonation wave. The analysis is based on the integration of one-dimensional reactive Euler equations with friction forces using a third-order Runge–Kutta scheme and a fifth-order weighted essentially non-oscillatory (WENO5) spatial discretization. A one-step Arrhenius reaction mechanism is used for modelling the chemical reaction. When the frictional forces are active, the limit cycle based on the post-shock pressure reveals an enhanced pulsating behaviour of the downstream subsonic reaction zone compared to the ideal case. The results show that the detonation-velocity deficit increases as the mean reaction zone becomes thicker compared to the generalized ZND model. A new master equation, based on the Favre-averaged quantities, is derived and analysed along with new sonicity and thermicity conditions. The analysis of the species, momentum and energy balances reveals that the presence of mechanical fluctuations within the reaction zone constitutes another source of energy withdrawal, meaning that the detonation deviates from its laminar structure. Furthermore, the compressibility of the flow is analysed and the relationships between the fluctuations of temperature, velocity and reactive scalar are discussed in terms of strong Reynolds analogies.
Intragenus generalized transduction in Staphylococcus spp. by a novel giant phage
Authors: Uchiyama Jumpei , Takemura-Uchiyama Iyo , Sakaguchi Yoshihiko , Gamoh Keiji , Kato Shin-ichiro , Daibata Masanori , Ujihara Takako , Misawa Naoaki , Matsuzaki Shigenobu 
Published: March 2014

Abstract
Bacteriophage (phage)-mediated generalized transduction is expected to contribute to the emergence of drug-resistant staphylococcal clones in various environments. In this study, novel phage S6 was isolated from sewage and used to test generalized transduction in human- and animal-derived staphylococci. Phage S6 was a novel type of giant myophage, which possessed a DNA genome that contained uracil instead of thymine, and it could infect all of the tested staphylococcal species. The phage S6 appeared to be similar to the transducing phage PBS1, which infects Bacillus spp. Moreover, phage S6 facilitated the transduction of a plasmid in Staphylococcus aureus and from S. aureus to non-aureus staphylococcal species, as well as vice versa. Transduction of methicillin resistance also occurred in S. aureus. This is the first report of successful intragenus generalized transduction among staphylococci.
Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line
Authors: Loh Siau-Lin , Teh Cathleen , Muller Julius , Guccione Ernesto , Hong Wanjin , Korzh Vladimir 
Published: March 2014

AbstractThe evolutionarily conserved Hippo signaling pathway controls organ size by regulating cell proliferation and apoptosis and this process involves Yap1. The zebrafish Yap1 acts during neural differentiation, but its function is not fully understood. The detailed analysis of yap1 expression in proliferative regions, revealed it in the otic placode that gives rise to the lateral line system affected by the morpholino-mediated knockdown of Yap1. The comparative microarray analysis of transcriptome of Yap1-deficient embryos demonstrated changes in expression of many genes, including the Wnt signaling pathway and, in particular, prox1a known for its role in development of mechanoreceptors in the lateral line. The knockdown of Yap1 causes a deficiency of differentiation of mechanoreceptors and this defect can be rescued by prox1a mRNA. Our studies revealed a role of Yap1 in regulation of Wnt signaling pathway and its target Prox1a during differentiation of mechanosensory cells.
Rapid generation of a mouse model for Middle East respiratory syndrome
Authors: Zhao Jincun , Li Kun , Wohlford-Lenane Christine , Agnihothram Sudhakar S. , Fett Craig , Zhao Jingxian , Gale Michael J. , Baric Ralph S. , Enjuanes Luis , Gallagher Tom , McCray Paul B. , Perlman Stanley 
Published: March 2014

Significance
The Middle East respiratory syndrome (MERS)-coronavirus, a newly identified pathogen, causes severe pneumonia in humans, with a mortality of nearly 44%. Human-to-human spread has been demonstrated, raising the possibility that the infection could become pandemic. Mice and other small laboratory animals are not susceptible to infection. Here, we describe the development of a small-animal model for MERS, in which we use an adenovirus expressing the human host-cell receptor to sensitize mice for infection. We show that these mice are useful for determining immune responses and for evaluation of an anti-MERS vaccine and an antiviral therapy. This approach will be generally useful for the rapid (2–3 wk) development of relevant mouse and other animal models for emerging viral infections.
Clinical Microbiology Costs for Methods of Active Surveillance for Klebsiella pneumoniae Carbapenemase–Producing Enterobacteriaceae
Authors: Mathers Amy J. , Poulter Melinda , Dirks Dawn , Carroll Joanne , Sifri Costi D. , Hazen Kevin C. 
Published: March 2014

Objective.To compare direct laboratory costs of different methods for perirectal screening for carbapenemase-producing Enterobacteriaceae (CPE) colonization.Design.Cost-benefit analysis.Setting.A university hospital and affiliated long-term acute care hospital (LTACH).Participants.Inpatients from the hospital or LTACH.Methods.Perirectal samples were collected from inpatients at risk for exposure to CPE. In 2009, we compared the accuracy of the Centers for Disease Control and Prevention (CDC)-recommended CPE screening method with similar methods incorporating a chromogenic agar (CA). We then performed a cost projection analysis using 2012 screening results for the CA method, the CDC method, and a molecular assay with wholesale pricing based on the 2009 analysis. Comparisons of turnaround and personnel time were also performed.Results.A total of 185 (2.7%) of 6,860 samples were confirmed as CPE positive during 2012. We previously found that the CDC protocol had a lower sensitivity than the CA method and predicted that the CDC protocol would have missed 92 of the CPE-positive screening results, whereas the modified protocol using CA would have missed 26, assuming similar prevalence and performance. Turnaround time was 3 days using the CDC and CA-modified protocols compared with 1 day for molecular testing. The estimated annual total program cost and total technologist's hours would be the following: CA-modified protocol, $37,441 and 376 hours; CDC protocol, $22,818 and 482 hours; and molecular testing, $224,596 and 343 hours.Conclusions.The CDC screening protocol appeared to be the least expensive perirectal screening method. However, expense must be weighed against a lower sensitivity and extra labor needed for additional work-up of non-CPE isolates. The molecular test has the shortest turnaround time but the greatest expense.
Establishment of a Statewide Network for Carbapenem-Resistant Enterobacteriaceae Prevention in a Low-Incidence Region
Authors: Pfeiffer Christopher D. , Cunningham Margaret C. , Poissant Tasha , Furuno Jon P. , Townes John M. , Leitz Andrew , Thomas Ann , Buser Genevieve L. , Arao Robert F. , Beldavs Zintars G. 
Published: March 2014

Objective.To establish a statewide network to detect, control, and prevent the spread of carbapenem-resistant Enterobacteriaceae (CRE) in a region with a low incidence of CRE infection.Design.Implementation of the Drug Resistant Organism Prevention and Coordinated Regional Epidemiology (DROP-CRE) Network.Setting and Participants.Oregon infection prevention and microbiology laboratory personnel, including 48 microbiology laboratories, 62 acute care facilities, and 140 long-term care facilities.Methods.The DROP-CRE working group, comprising representatives from academic institutions and public health, convened an interdisciplinary advisory committee to assist with planning and implementation of CRE epidemiology and control efforts. The working group established a statewide CRE definition and surveillance plan; increased the state laboratory capacity to perform the modified Hodge test and polymerase chain reaction for carbapenemases in real time; and administered surveys that assessed the needs and capabilities of Oregon infection prevention and laboratory personnel. Results of these inquiries informed CRE education and the response plan.Results.Of 60 CRE reported from November 2010 through April 2013, only 3 were identified as carbapenemase producers; the cases were not linked, and no secondary transmission was found. Microbiology laboratories, acute care facilities, and long-term care facilities reported lacking carbapenemase testing capability, reliable interfacility communication, and CRE awareness, respectively. Survey findings informed the creation of the Oregon CRE Toolkit, a state-specific CRE guide booklet.Conclusions.A regional epidemiology surveillance and response network has been implemented in Oregon in advance of widespread CRE transmission. Prospective surveillance will determine whether this collaborative approach will be successful at forestalling the emergence of this important healthcare-associated pathogen.
Statewide Surveillance of Carbapenem-Resistant Enterobacteriaceae in Michigan
Authors: Brennan Brenda M. , Coyle Joseph R. , Marchaim Dror , Pogue Jason M. , Boehme Martha , Finks Jennie , Malani Anurag N. , VerLee Kerrie E. , Buckley Bryan O. , Mollon Noreen , Sundin Daniel R. , Washer Laraine L. , Kaye Keith S. 
Published: March 2014

Background.Carbapenem-resistant Enterobacteriaceae (CRE) are clinically challenging, threaten patient safety, and represent an emerging public health issue. CRE reporting is not mandated in Michigan.Methods.The Michigan Department of Community Health–led CRE Surveillance and Prevention Initiative enrolled 21 facilities (17 acute care and 4 long-term acute care facilities) across the state. Baseline data collection began September 1, 2012, and ended February 28, 2013 (duration, 6 months). Enrolled facilities voluntarily reported cases of Klebsiella pneumoniae and Escherichia coli according to the surveillance algorithm. Patient demographic characteristics, laboratory testing, microbiology, clinical, and antimicrobial information were captured via standardized data collection forms. Facilities reported admissions and patient-days each month.Results.One-hundred two cases over 957,220 patient-days were reported, resulting in a crude incidence rate of 1.07 cases per 10,000 patient-days. Eighty-nine case patients had test results positive for K. pneumoniae, whereas 13 had results positive for E. coli. CRE case patients had a mean age of 63 years, and 51% were male. Urine cultures (61%) were the most frequently reported specimen source. Thirty-five percent of cases were hospital onset; sixty-five percent were community onset (CO), although 75% of CO case patients reported healthcare exposure within the previous 90 days. Cardiovascular disease, renal failure, and diabetes mellitus were the most frequently reported comorbid conditions. Common ris k factors included surgery within the previous 90 days, recent infection or colonization with a multidrug-resistant organism, and recent exposures to antimicrobials, especially third- or fourth-generation cephalosporins.Conclusions.CRE are found throughout Michigan healthcare facilities. Implementing a regional, coordinated surveillance and prevention initiative may prevent CRE from becoming hyperendemic in Michigan.
Meteorological conditions influence short-term survival and dispersal in a reinforced long-lived bird population.
Authors: Hardouin Loïc A. , Robert A. , Nevoux M. , Gimenex O. , Lacroix F. , Hingrat Yves 
Published: March 2014

AbstractA high immediate mortality rate of released animals is an important cause of translocation failure (“release cost”). Post-release dispersal (i.e. the movements from the release site to the first breeding site) has recently been identified as another source of local translocation failure. In spite of their potential effects on conservation program outcomes, little is known about the quantitative effects of these two sources of translocation failure and their interactions with environmental factors and management designs.Based on long-term monitoring data of captive-bred North African houbara bustards (hereafter, houbaras) over large spatial scales, we investigated the relative effects of release (e.g., release group size, period of release), individual (e.g., sex and body condition) and meteorological (e.g., temperature and rainfall) conditions on post-release survival (N = 957 houbaras) and dispersal (N = 436 houbaras).We found that (i) rainfall and ambient air temperature had respectively a negative and a positive effect on houbara post-release dispersal distance, (ii) in interaction with the release period, harsh meteorological conditions had negative impact on the survival of houbaras, (iii) density dependent processes influenced the pattern of departure from the release site and (iv) post-release dispersal distance was male-biased, as natal dispersal of wild birds (although the dispersal patterns and movements may be influenced by different processes in captive-bred and in wild birds).Synthesis and applications.Overall, our results demonstrate that post-release dispersal and mortality costs in translocated species may be mediated by meteorological factors, which in turn can be buffered by the release method. As the consequences of translocation programs on population dynamics depend primarily upon release costs and colonisation process, we suggest that their potential interactions with meteorological conditions be carefully addressed in future programs.
Applicant, rater, and job factors related to weight-based bias
Authors: Contreras Krueger Dianna , L. Stone Dianna , Stone-Romero Eugene 
Published: March 2014

Purpose
– The aim of this paper was to assess the main and interactive effects of job applicant conscientiousness, and nurturing job demands on ratings of overweight female applicants on job suitability and a hiring recommendation. It also examined relations between rater ethnicity and ratings of the job suitability of normal and overweight applicants.

Design/methodology/approach
– The study used a 2×2×2 experimental design and data from 400 individuals (201 Anglos and 199 Hispanics) with hiring experience to test the study's hypotheses. Participants were randomly assigned to conditions, and asked to review a resume and picture of a normal or overweight applicant. Then, they were asked to rate the applicant's job suitability and make a hiring recommendation.

Findings
– The results revealed that: overweight female applicants were rated as more suitable for jobs and more likely to be recommended for hire when they had high rather than low conscientiousness; Hispanics were more likely to recommend overweight applicants for hire than Anglos; and there was a three-way interaction among applicant weight, rater ethnicity, and nurturing job demands for the hiring recommendation criterion.

Research limitations/implications
– The study was conducted in a simulated hiring context. Thus, research is needed to determine if the results generalize to actual work settings.

Practical implications
– The results suggest that organizations should provide decision makers with detailed information about applicants' conscientiousness, and the nurturing demands of jobs. When these types of information are presented, raters are less likely to display weight-based bias.

Originality/value
– Previous research on weight-based bias was not based on a theoretical model, but the present study used a theoretical framework to guide the development of hypotheses (Stone and Colella, 1996; Stone et al., 1992). In addition, it is the first study to examine the effects of overweight applicant conscientiousness and stereotype-job fit on ratings of job suitability, and differences between Hispanic and Anglo views of overweight applicants.
Pregnancy in women with a history of Kawasaki disease: management and outcomes
Authors: Gordon CT , Jimenez‐Fernandez S , Daniels LB , Kahn AM , Tarsa M , Matsubara T , Shimizu C , Burns JC , Gordon JB 
Published: March 2014

ObjectiveTo characterise the obstetrical management and outcomes in a series of women with a history of Kawasaki disease (KD) in childhood.DesignRetrospective case series.SettingTertiary healthcare setting in the USA.PopulationWomen with a history of KD in childhood.MethodsWomen completed a detailed health questionnaire and participated in research imaging studies as part of the San Diego Adult KD Collaborative Study.Main outcome measuresObstetrical management, complications during pregnancy and delivery, and infant outcomes.ResultsTen women with a history of KD in childhood carried a total of 21 pregnancies to term. There were no cardiovascular complications during labour and delivery despite important cardiovascular abnormalities in four of the ten subjects. Pregnancy was complicated by pre‐eclampsia and the post‐partum course was complicated by haemorrhage in one subject each. Two of the 21 progeny subsequently developed KD.ConclusionsWomen with important cardiovascular sequelae from KD in childhood should be managed by a team that includes both a maternal–fetal medicine specialist and a cardiologist. Pre‐pregnancy counselling should include delineation of the woman's current functional and structural cardiovascular status and appropriate adjustment of medications, but excellent outcomes are possible with appropriate care. Review of the English and Japanese literature on KD and pregnancy revealed the occurrence of myocardial infarction during pregnancy in women with missed KD and aneurysms that were not diagnosed until their acute event. Our study highlights the need for counselling with regard to the increased genetic risk of KD in offspring born to these mothers.
Lesions of dorsal striatum eliminate lose‐switch responding but not mixed‐response strategies in rats
Authors: Skelin Ivan , Hakstol Rhys , VanOyen Jenn , Mudiayi Dominic , Molina Leonardo A. , Holec Victoria , Hong Nancy S. , Euston David R. , McDonald Robert J. , Gruber Aaron J. 
Published: March 2014

AbstractWe used focal brain lesions in rats to examine how dorsomedial (DMS) and dorsolateral (DLS) regions of the striatum differently contribute to response adaptation driven by the delivery or omission of rewards. Rats performed a binary choice task under two modes: one in which responses were rewarded on half of the trials regardless of choice; and another ‘competitive’ one in which only unpredictable choices were rewarded. In both modes, control animals were more likely to use a predictable lose‐switch strategy than animals with lesions of either DMS or DLS. Animals with lesions of DMS presumably relied more on DLS for behavioural control, and generated repetitive responses in the first mode. These animals then shifted to a random response strategy in the competitive mode, thereby performing better than controls or animals with DLS lesions. Analysis using computational models of reinforcement learning indicated that animals with striatal lesions, particularly of the DLS, had blunted reward sensitivity and less stochasticity in the choice mechanism. These results provide further evidence that the rodent DLS is involved in rapid response adaptation that is more sophisticated than that embodied by the classic notion of habit formation driven by gradual stimulus–response learning.