bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inefficient tissue immune response against MPXV in an immunocompromised mpox patient
Authors: Matschke Jakob , Hartmann Kristin , Pfefferle Susanne , Wang Yue , Valdes Pablo A. , Thies Edda , Schweizer Michaela , Lütgehetmann Marc , Schmiedel Stefan , Bernreuther Christian , Boyden Edward S. , Glatzel Markus , Krasemann Susanne 
Published: July 2024

AbstractThe recent outbreak of monkeypox virus (MPXV) was unprecedented in its size and distribution. Those living with uncontrolled HIV and low CD4 T cell counts might develop a fulminant clinical mpox course with increased mortality, secondary infections, and necrotizing lesions. Fatal cases display a high and widespread MPXV tissue burden. The underlying pathomechanisms are not fully understood. We report here the pathological findings of an MPXV‐driven abscess in gastrocnemius muscle requiring surgery in an immunocompromised patient with severe mpox. Presence of virus particles and infectivity were confirmed by electron microscopy, expansion microscopy, and virus culture, respectively. MPXV tissue distribution by immunohistochemistry (IHC) showed a necrotic core with infection of different cell types. In contrast, at the lesion rim fibroblasts were mainly infected. Immune cells were almost absent in the necrotic core, but were abundant at the infection rim and predominantly macrophages. Further, we detected high amounts of alternatively activated GPNMB+‐macrophages at the lesion border. Of note, macrophages only rarely colocalized with virus‐infected cells. Insufficient clearance of infected cells and infection of lesion‐associated fibroblasts sustained by the abundance of profibrotic macrophages might lead to the coalescing of lesions and the severe and persistent clinical mpox course observed in immunocompromised patients.
An approaching method based on integral for linear neutral delay differential equations by using Hermite polynomials
Authors: Yüzbaşı Şuayip , Karaağaçlı Özlem 
Published: July 2024

AbstractThis article presents a approximation method for linear neutral delay differential equations using Hermite polynomials. The method ensures the unknown function to be found by approximating the first derivative with the help of the finite Hermite series. This method reduces the problem to a linear algebraic system using the first derivative approach, matrix operations and collocation points. Also error of the solution is estimated by constructing an error problem. Numerical examples are solved to explain the method and error estimation technique. The results demonstrate the effectiveness and accuracy of the current study. Calculations have been made using MATLAB.
Favourable clinical outcomes and low revision rate after M‐ACI in adolescents with immature cartilage compared to adult controls: Results at 10 years
Authors: Weishorn Johannes , Wiegand Johanna , Koch Kevin‐Arno , Trefzer Raphael , Renkawitz Tobias , Walker Tilman , Bangert Yannic 
Published: July 2024

AbstractPurposeThe purpose of this study was to evaluate long‐term survival, patient‐reported outcomes (PROs) and radiographic results of matrix‐associated autologous chondrocyte implantation (M‐ACI) in adolescents with immature cartilage and compare them to adult controls.MethodsA retrospective matched‐pair analysis was performed comparing the PRO after M‐ACI for focal cartilage defect of the knee in cartilaginous immature adolescents to mature adults. Groups were matched for sex, body mass index, defect site and size, symptom duration and the number of previous knee surgeries. Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART 2.0) scores were assessed at least 60 months postoperatively. Patient acceptable symptomatic state (PASS) and clinical response rate in KOOS and KOOS subscores were calculated.ResultsA total of 54 patients were matched. At a mean of 96 months (65–144 months), no surgical complications, graft hypertrophy or reoperations were noted in the cohorts studied. Adolescents showed superior PROs at the final follow‐up (76.9 ± 14.1 vs. 66.4 ± 15.0, p = 0.03) and were significantly more likely to achieve PASS (74.1% vs. 55.6%; p = 0.02) compared to the adult cohort. The KOOS subscale analysis showed long‐term benefits for adolescents in terms of symptom improvement, pain reduction, activities of daily living, sports and quality of life (p < 0.05). None of the patients in the adolescent group showed graft hypertrophy on magnet resonance imaging or signs of osteoarthritis on radiographs at long‐term follow‐ups.ConclusionsM‐ACI is an effective treatment for chondral defects of the knee in patients with immature cartilage with low revision rates and high patient satisfaction over the long term. Adolescents showed comparable clinical and radiographic results in the short and medium term, with slightly more favourable, clinically relevant functional results in adolescents in the long term. M‐ACI can be safely used in adolescents, and consideration should be given to expanding the indication to include these patients.Level of EvidenceLevel III.
Ligament augmentation and reconstruction system (LARS) synthetic grafts are safe and effective for medial collateral ligament and posterolateral corner reconstructions in elite athletes
Authors: Jones Mary , Pinheiro Vitor H. , Church J. Samuel , Ball Simon V. , Williams Andy 
Published: July 2024

AbstractPurposeThis study documents the efficacy and safety of using a Ligament Augmentation and Reconstruction System (LARS) ligament graft to augment extra‐articular knee ligament reconstructions in elite athletes by reporting return‐to‐play (RTP) rates and levels, career longevity and complications.MethodsA consecutive series of all extra‐articular knee ligament reconstructions augmented by LARS ligaments in elite athletes undertaken by three specialist sports knee surgeons between 2013 and 2020 were reviewed. Seventy‐six elite athletes, aged over 16 years old, and more than 2 years postsurgery were included. RTP was defined as competing at professional level or national/international level in amateur sport.ResultsThere were 64 medial collateral ligament (MCL) and 12 posterolateral corner (PLC) reconstructions. Fifty‐two (68.4%) underwent concomitant autograft cruciate ligament(s) reconstruction. The mean age was 25.1 years (SD ± 4.5). Most were football (35, 46.1%) or rugby players (35, 46.1%). Sixty‐seven athletes (88.2%) RTP with 65 (97.0%) of these playing at the same or higher Tegner level. Fifty‐six (83.6%) of the athletes that RTP were still playing at 2 years postsurgery. Twenty (57.1%) of those who had RTP and were more than 5 years postsurgery were still playing at 5 years. Six (7.9%) players required further surgery relating to the LARS/metalwork. One case had soft tissue inflammation adjacent to the proximal end of the synthetic graft, but it is unknown if this was mechanical irritation or a biological reaction. One MCL reruptured 4 years after RTP.ConclusionUtilising LARS to augment extra‐articular knee ligament reconstructions allows 88.2% of athletes with a variety of knee ligament injuries to return to elite sport. The low morbidity rates coupled with 57% of athletes still playing 5 years postsurgery demonstrates that the LARS is safe and effective in these cases. Although there are reports of LARS ligaments being used in MCL and PLC reconstructions, there is very little evidence investigating if they are safe and effective. This study demonstrates that LARS synthetic grafts can be safely used for MCL and PLC reconstructions in elite athletes and they permit a high RTP with a low risk of complications.Level of EvidenceLevel IV.
Increased combined anteversion is associated with larger posterior acetabular rim ossification in patients with femoroacetabular impingement syndrome
Authors: Zhang Hongguang , Zhang Siqi , Zhou Guangjin , Xu Yan 
Published: July 2024

AbstractPurpose(1) To determine the prevalence, magnitude and distribution pattern of acetabular rim ossification in patients with femoroacetabular impingement syndrome (FAIS) and (2) to determine the association between acetabular rim ossification and rotational abnormalities of the hip.MethodsPatients underwent hip arthroscopic surgery for FAIS at our institute between January 2021 and May 2022 were retrospectively reviewed. Patients were included if preoperative computed tomography (CT) images of the operated hip and ipsilateral distal femur were available for the measurement of femoral and acetabular anteversion. The presence and size of acetabular rim ossification were evaluated on coronal CT sections for the superior half of the acetabulum on each clockface location. The associations between acetabular rim ossification and radiographic parameters of hip rotational morphology were examined.ResultsA total of 214 hips were included. Acetabular rim ossification was found in 167 hips (78%) and the most common locations were 10 and 11 o'clock. Patients presenting with acetabular rim ossification had a mean size of 4.6 ± 1.6 mm. It was the largest at 9 o'clock position (4.9 ± 2.2 mm), with a decreasing trend in size from posterior to anterior. Logistics regression analysis found age was associated with the occurrence of posterior ossification (p = 0.002). Linear regression analysis found age (p = 0.049) and male sex (p < 0.001) were significantly correlated with the size of ossification. Patients with increased cranial combined anteversion had larger posterior ossification than patients with normal and decreased cranial combined anteversion (4.2 ± 2.9 vs. 3.1 ± 2.5 mm, p = 0.016; 4.2 ± 2.9 vs. 2.5 ± 2.4 mm, p = 0.005).ConclusionIncreased combined anteversion is associated with greater posterior acetabular rim ossification. The presence and size of acetabular rim ossification are positively associated with older age and male sex.Level of EvidenceLevel III.
Treatment of Iron‐Induced Cutaneous Hyperpigmentation With Energy‐Based Devices
Authors: Sharma Ajay N. , Golbari Nicole M. , Grushchak Solomiya , Andrade Adriana Ribas , Zachary Christopher B. 
Published: July 2024

ABSTRACTObjectivesIatrogenic cutaneous siderosis is a well‐recognized dermatologic complication after parenteral iron infusion. The condition manifests as discrete, hyperpigmented patches near the site of injection. Most cases do not resolve spontaneously, leading to significant aesthetic and psychological distress to patients. A recent case of iatrogenic cutaneous siderosis at our institution prompted a systematic review of the efficacy of energy‐based devices previously reported in the treatment of this condition.MethodsPubMed and Cochrane databases were searched for all peer‐reviewed articles published using the following search terms: “iron OR heme OR hemosiderosis OR siderosis” and “hyperpigmentation OR staining OR tattoo.” Articles reporting on energy‐based devices in the treatment of iron‐induced hyperpigmentation were included.ResultsA total of seven articles and 54 total patients were included in this review. All patients, including the patient treated at our institution, were female, with an average age of 44 years. Hyperpigmentation was most commonly associated with intravenous iron infusion (48/54, 89%), on the arm or forearm (44/54, 81%), and used for the treatment of underlying iron deficiency anemia (54/54, 100%). The application of six different nanosecond or picosecond quality‐switched laser systems was reported in the treatment of cutaneous siderosis, with wavelengths ranging from 532 to 1064 nm. Spot sizes varied between 2 and 7 mm, with energy fluences spanning 0.5–40 J/cm2 depending on both the device and spot size. Outcomes were measured after an average of 5.4 laser treatments and 10.4 months, with over half of all reported patients experiencing complete clearance (27/50, 54%). Our patient received treatment in three test areas with picosecond alexandrite 785 nm, nanosecond Nd:YAG 532 nm, and picosecond Nd:YAG 532 nm devices. The nanosecond Nd:YAG 532 nm treated area demonstrated the greatest improvement, and the entire arm was subsequently treated with this device.ConclusionsDespite the often intractable nature of iatrogenic cutaneous siderosis, laser surgery is a reasonable and safe treatment modality for patients seeking cosmetic improvement of this dyschromia. Dermatologists should be aware of this entity and the efficacy of the energy‐based devices currently in our armamentarium. A combination approach may need to be utilized with different wavelengths and pulsed widths to target iron pigment in both dermal and subcutaneous layers.
The Hartogs–Lindenbaum spectrum of symmetric extensions
Authors: Ryan‐Smith Calliope 
Published: July 2024

AbstractWe expand the classic result that is equivalent to the statement “For all , ” by proving the equivalence of many more related statements. Then, we introduce the Hartogs–Lindenbaum spectrum of a model of , and inspect the structure of these spectra in models that are obtained by a symmetric extension of a model of . We prove that all such spectra fall into a very rigid pattern.
Development of Macromolecular Cryoprotectants for Cryopreservation of Cells
Authors: Yuan Liang , Chen Binlin , Zhu Kongying , Ren Lixia , Yuan Xiaoyan 
Published: July 2024

AbstractCryopreservation is a common way for long‐term storage of therapeutical proteins, erythrocytes, and mammalian cells. For cryoprotection of these biosamples to keep their structural integrity and biological activities, it is essential to incorporate highly efficient cryoprotectants. Currently, permeable small molecular cryoprotectants such as glycerol and dimethyl sulfoxide dominate in cryostorage applications, but they are harmful to cells and human health. As acting in the extracellular space, membrane‐impermeable macromolecular cryoprotectants, which exert remarkable membrane stabilization against cryo‐injury and are easily removed post‐thaw, are promising candidates with biocompatibility and feasibility. Water‐soluble hydroxyl‐containing polymers such as poly(vinyl alcohol) and polyol‐based polymers are potent ice recrystallization inhibitors, while polyampholytes, polyzwitterions, and bio‐inspired (glyco)polypeptides can significantly increase post‐thaw recovery with reduced membrane damages. In this review, the synthetic macromolecular cryoprotectants are systematically summarized based on their synthesis routes, practical utilities, and cryoprotective mechanisms. It provides a valuable insight in development of highly efficient macromolecular cryoprotectants with valid ice recrystallization inhibition activity for highly efficient and safe cryopreservation of cells.
Reduced B0/B1+ sensitivity in velocity‐selective inversion arterial spin labeling using adiabatic refocusing pulses
Authors: Bolar Divya S. , Barnes Ryan A. , Chen Conan , Han Fei , Pfeuffer Josef , Liu Thomas T. , Wong Eric C. 
Published: July 2024

AbstractPurposeTo mitigate the B0/B1+ sensitivity of velocity‐selective inversion (VSI) pulse trains for velocity‐selective arterial spin labeling (VSASL) by implementing adiabatic refocusing. This approach aims to achieve artifact‐free VSI‐based perfusion imaging through single‐pair label‐control subtractions, reducing the need for the currently required four‐pair dynamic phase‐cycling (DPC) technique when using a velocity‐insensitive control.MethodsWe introduce a Fourier‐transform VSI (FT‐VSI) train that incorporates sinc‐modulated hard excitation pulses with MLEV‐8‐modulated adiabatic hyperbolic secant refocusing pairs. We compare performance between this train and the standard composite refocusing train, including with and without DPC, for dual‐module VSI VSASL. We evaluate (1) simulated velocity‐selective profiles and subtraction fidelity across a broad B0/B1+ range, (2) subtraction fidelity in phantoms, and (3) image quality, artifact presence, and gray‐matter perfusion heterogeneity (as measured by the spatial coefficient of variation) in healthy human subjects.ResultsAdiabatic refocusing significantly improves FT‐VSI robustness to B0/B1+ inhomogeneity for a single label‐control subtraction. Subtraction fidelity is dramatically improved in both simulation and phantoms compared with composite refocusing without DPC, and is similar compared with DPC methods. In humans, marked artifacts seen with the non‐DPC composite refocusing approach are eliminated, corroborated by significantly reduced gray‐matter heterogeneity (via lower spatial coefficient of variation values).ConclusionA novel VSASL labeling train using adiabatic refocusing pulses for VSI was found to reduce artifacts related to B0/B1+ inhomogeneity, thereby providing an alternative to DPC and its associated limitations, which include increased vulnerability to physiological noise and motion, reduced functional MRI applicability, and suboptimal data censoring.
A multiobjective optimization framework for site investigation program based on Bayesian approach and NSGA‐II
Authors: Sun Yang , Xu Ziying , Sun Jinshan , Chen Zhen 
Published: July 2024

AbstractSite investigation provides essential geotechnical parameter information for analysis and design. However, three conflicting objectives, namely exploration effort, robustness and parameter uncertainty, pose a challenge to the development of an optimal site investigation program. In this study, a three objective optimization framework for the site investigation program is proposed based on the Bayesian approach and the non‐dominated sorting genetic algorithm (NSGA‐II). The only inputs required by the proposed framework are prior distribution of geotechnical parameters and error information. The prior distribution of geotechnical parameters is derived from integrating engineering experience and measurements from basic exploration boreholes. The error information is obtained based on literature and expert judgment related to the specific project. Firstly, a design pool of candidate investigation programs is generated using Bayesian approach to determine the locations and number of exploration boreholes. The NSGA‐II is then applied to identify the optimal program that balances lower cost, higher robustness, and lower uncertainty. The proposed multiobjective optimization framework is illustrated and validated through a real site investigation case in Chongqing, China, aimed at determining the ultimate bearing capacity of the rock foundation. The spatial correlation of parameters within the study area is also considered. The optimal program is represented by the location and number of exploration boreholes. By comparing measurements with predictions from different site investigation programs, the efficiency of the proposed multiobjective framework is demonstrated. Additionally, the influence of engineering experience and random field modeling on the investigation program is discussed.
The AUA/SUFU guideline on the diagnosis and treatment of idiopathic overactive bladder
Authors: Cameron Anne P. , Chung Doreen E. , Dielubanza Elodi J. , Enemchukwu Ekene , Ginsberg David A. , Helfand Brian T. , Linder Brian J. , Reynolds W. Stuart , Rovner Eric S. , Souter Lesley , Suskind Anne M. , Takacs Elizabeth , Welk Blayne , Smith Ariana L. 
Published: July 2024

AbstractPurposeThe purpose of this guideline is to provide evidence‐based guidance to clinicians of all specialties on the evaluation, management, and treatment of idiopathic overactive bladder (OAB). The guideline informs the reader on valid diagnostic processes and provides an approach to selecting treatment options for patients with OAB through the shared decision‐making process, which will maximize symptom control and quality of life, while minimizing adverse events and burden of disease.MethodsAn electronic search employing OVID was used to systematically search the MEDLINE and EMBASE databases, as well as the Cochrane Library, for systematic reviews and primary studies evaluating diagnosis and treatment of OAB from January 2013 to November 2023. Criteria for inclusion and exclusion of studies were based on the Key Questions and the populations, interventions, comparators, outcomes, timing, types of studies and settings (PICOTS) of interest. Following the study selection process, 159 studies were included and were used to inform evidence‐based recommendation statements.ResultsThis guideline produced 33 statements that cover the evaluation and diagnosis of the patient with symptoms suggestive of OAB; the treatment options for patients with OAB, including Noninvasive therapies, pharmacotherapy, minimally invasive therapies, invasive therapies, and indwelling catheters; and the management of patients with BPH and OAB.ConclusionOnce the diagnosis of OAB is made, the clinician and the patient with OAB have a variety of treatment options to choose from and should, through shared decision‐making, formulate a personalized treatment approach taking into account evidence‐based recommendations as well as patient values and preferences.
A two‐stage adaptive robust model for designing a reliable blood supply chain network with disruption considerations in disaster situations
Authors: Qing Ling , Yin Yunqiang , Wang Dujuan , Yu Yugang , Cheng T. C. E. 
Published: July 2024

AbstractWe consider multi‐period blood supply chain network design in disaster situations that involve blood donor groups, permanent and temporary blood collection facilities, blood banks, and hospitals. We use a discrete scenario set to model the uncertain blood supply and demand, and the unforeseeable disruptions in permanent blood collection facilities, blood banks, and road links arising from a disaster, where instead of complete failure, disrupted permanent blood collection facilities and blood blanks may only lose part of their capacities. To design a reliable blood supply network to mitigate the possible disruptions, we present a two‐stage adaptive robust model that integrates the location, inventory, and allocation decisions incorporating a blood sharing strategy, where blood can be delivered from a disrupted/non‐disrupted blood bank to disrupted blood banks to enhance the flexibility of the relief network. For this novel problem, we devise an exact algorithm that integrates column‐and‐constraint generation and Benders decomposition and introduce several non‐trivial acceleration techniques to speed up the solution generation process. We conduct extensive numerical studies on random data sets to evaluate the algorithmic performance. We also conduct a case study in Tehran to demonstrate its real‐life applicability and examine the impacts of key model parameters on the solutions. The numerical results verify the benefits of our model over typical benchmarks, that is, deterministic and stochastic models, and the superiority of our solution algorithm over the CPLEX solver and two well‐known solution approaches, that is, column‐and‐constraint generation and Benders decomposition. Finally, based on the numerical results, we derive managerial insights from the analytical findings.