bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of a dedicated transition process from pediatric to adult interdisciplinary care for persons with spina bifida
Authors: Jiminez Victoria , Hopson Betsy , Caudill Caroline , Arynchyna-Smith Anastasia , Rogers Suzannah , Rocque Brandon G. , Blount Jeffrey P. 
Published: August 2024

OBJECTIVE
Interdisciplinary care and pediatric to adult transitional programs have consistently shown medical and social value for individuals with complex medical conditions such as spina bifida (SB). Such interdisciplinary clinics are common in pediatrics but are rarely offered for adults. This survey-based study reports information related to transition, daily pain burden, and satisfaction with care delivery in an adult SB clinic.

METHODS
A 23-question survey that was based on empirical observations from the adult SB clinic was formulated, IRB approved, and distributed to adult patients. Many respondents had previously received care at the institution’s pediatric SB clinic and completed transition to the adult program. Responses were de-identified, categorized, stored in a secure database, and statistically analyzed using SPSS.

RESULTS
Of 245 patients approached, 116 (47%) surveys were completed and analyzed. Those who had a direct transition (defined as a less than 24-month gap in care) from the pediatric to the adult clinic comprised 44% (n = 51) of responders. The alternative group of 56% (n = 65) had a longer gap, disorganized or absent transition, or had pediatric care elsewhere. The study population had an average age of 36 years, had mostly received childhood care at the authors’ institution, regardless of whether they made a direct transition or had a gap in care (68%), and held the diagnosis of open myelomeningocele (78%). Overall satisfaction with the clinic experience was high (mean score 9.04 on a 10-point subjective scale). Differences regarding independence in activities of daily living based on transition status were not significant, but on multivariate analysis, those who reported independence in activities of daily living had an almost 4-fold higher odds of daily pain (p = 0.024; OR 3.86, 95% CI 1.19–12.5). The most frequently identified areas for improvement included improved access to care and pain control.

CONCLUSIONS
Pediatric transitional processes and interdisciplinary clinics may contribute to improved patient-perceived outcomes and satisfaction with their SB care in comprehensive settings. Further elucidation of barriers to pain control is warranted, in addition to ways in which comprehensive and longitudinal care can improve them.
Transition mentorship for spina bifida patients with the JUMP program: a pilot study
Authors: Maleknia Pedram D. , Hopson Logan , Blount Jeffrey P. , Rocque Brandon G. , Arynchyna-Smith Anastasia , Hopson Betsy D. 
Published: August 2024

OBJECTIVE
The transition from pediatric to adult care is challenging for patients and families with spina bifida (SB). Lifelong care relationships yield to new care environments that are typically larger, less personal, and less engaged with the nuances of SB care. Adolescence and young adulthood are often characterized by personal and psychological stresses due to factors independent of illness or chronic medical complexity. Surveys have demonstrated that transition is associated with uncertainty, anxiety, and elevated risk of adverse events for many SB patients. To help mitigate this, the authors developed a trial mentorship program between teen patients with SB and undergraduate/medical students. This study analyzes and presents the initial outcomes from this program.

METHODS
The authors created the Join, Unite, Motivate, and Prepare (JUMP) program to improve readiness for the transition process. The mentee target population was patients aged 13–19 years receiving care at the authors’ SB clinic. Mentors were screened/approved undergraduate/medical students who volunteered to participate and successfully completed online training in mentorship. Upon enrollment, each patient set a combination of clinical, self, and parent/guardian goals using the individualized transition plan. These goals were shared with the mentor, mentee, parent/guardian, and physician. To monitor success, the SB program director routinely met with each mentor to discuss progress made and areas of growth. These included continuous quantitative and qualitative goal setting and failures that needed to be addressed for each agenda.

RESULTS
Thirteen mentor-mentee matches were created over 9 months. Of the 13 matches, 6 had more than 5 communications after the initial meeting, and 1 mentor-mentee match is still in contact today. Noted success in the program has been through mentees gaining employment, applying for scholarships, starting college, and connecting with others who are going through similar circumstances. Challenges have arisen through failure to follow-up after the initial office visit, risk with using the virtual platform, and wide geographic dispersion of both mentors and mentees across the authors’ state.

CONCLUSIONS
Transition from pediatric to adult care for adolescents with SB has proven to be a large hurdle. Easing this process through well-thought-out, interactive processes has the potential to improve readiness, increase patient autonomy, and provide exposure to the adult healthcare community. However, the mentorship model, in the SB setting, has not proven to be the remedy.
Online healthcare transition resources for pediatric neurosurgical care: supporting the journey of individuals living with spina bifida
Authors: Malhotra Anjali , Locastro Mary M. , Castillo Heidi , Lozano-Ramirez Juan Francisco , Gandy Kellen , Bradko Viachaslau , Lai Grace Y. , Castillo Jonathan 
Published: August 2024

OBJECTIVE
In the global environment in which neurosurgical providers practice, there is a pressing need to identify and highlight online resources to support families shifting from pediatric to adult-centered spina bifida (SB) care in general and neurosurgical care in particular. The purpose of this paper was to identify high-quality resources for clinicians and families of individuals affected by SB to be utilized during the transition years. With knowledge of, and access to, these online resources, neurosurgical providers can aim to make the transition process effective, to improve the quality of care for young adults with SB.

METHODS
All identified online resources were found on the GOT TRANSITION platform and by searching "spina bifida transition resources" between January and March 2024. Resources were coded for transition focus areas and stratified into predefined categories: 1) education for clinicians, 2) preparation for youth and families, 3) educational/school, and 4) employment and independent living.

RESULTS
A total of 160 websites were cataloged; 11% of websites focused on medical provider education, 44% on preparation for youth, 29% on educational/school resources, and 16% on employment and independent living.

CONCLUSIONS
In the global environment of today’s medicine, online transition resources are available to assist clinicians and families in the transition process of individuals living with SB. With improved knowledge and utilization of online transition resources, neurosurgical providers can better serve individuals with SB and their families to improve quality of care with the aim of improving lifelong outcomes.
Sistem Informasi Persediaan Barang Berbasis Web Di Toko Jam Sumber Terang Jember
Authors: Rahmawati Titasari , Andika Hermawan 
Published: August 2024

Perkembangan teknologi yang pesat membuat dunia bisnis menjadi lebih efisien dan efektif, sehingga informasi menjadi hal yang krusial bagi kesuksesan bisnis. Implementasi penyajian informasi untuk keperluan bisnis telah banyak diwujudkan dalam bentuk sistem informasi yang sangat diperlukan untuk mengelola dan memahami proses bisnis, terutama di lingkungan yang kompleks seperti Toko Jam Sumber Terang Jember, dimana karyawan yang ditugaskan melakukan pengecekan barang secara manual dengan media kertas, namun kemampuan terhadap data yang tidak ontime. Metode ini juga menyebabkan masalah seperti transmisi data yang tertunda dan penundaan dalam menangani pencatatan barang dalam jumlah besar. Masalah lain yang timbul adalah proses pencarian data akan memakan waktu yang lama. Penelitian ini bertujuan untuk merancang dan mengembangkan sebuah sistem website untuk memberikan informasi yang komprehensif tentang inventaris gudang dengan menggunakan metodologi pengembangan Waterfall. Sistem ini dirancang untuk mengatasi masalah keterlambatan dan ketidakefisienan yang disebabkan oleh pencatatan manual. Sistem informasi ini menggunakan teknologi HTML, PHP, Bootstrap CSS Framework, dan MySQL. Fitur-fitur utama yang disediakan meliputi login, pengelolaan data barang, kategori barang, user, checklist, persetujuan data checking barang, dan pembuatan laporan. Implementasi sistem mencakup spesifikasi perangkat keras dan lunak, serta antarmuka pengguna yang dirancang untuk mempermudah proses manajemen persediaan. Kesimpulan dari penelitian ini menunjukkan bahwa sistem informasi yang dikembangkan dapat membantu pengecekan barang dengan lebih cepat dan efisien. Saran untuk pengembangan lebih lanjut termasuk penambahan fitur inspeksi barang.
PERSEPSI BIAYA MEMODERASI PENGARUH KUALITAS PELAYANAN TERHADAP KEPUASAN PELANGGAN PERUMDA TIRTA CENDANA KEFAMENANU KABUPATEN TIMOR TENGAH UTARA
Authors: Duli Dominikus Kopong , Taolin Maximus L. , Manane Desmon Redikson 
Published: August 2024

Perumda Tirta Cendana adalah badan usaha milik Pemerintah Daerah Kabupaten Timor Tengah Utara, bergerak dalam bidang pelayanan air bersih dan memiliki banyak pelanggan. Para pelanggan berharap agar distribusi air bersih dapat memenuhi kebutuhan baik konsumsi maupun kebutuhan lainnya. Tujuan penelitian ini adalah untuk mengetahui seberapa besar pengaruh kualitas pelayanan dimoderasi persepsi biaya terhadap kepuasan pelanggan. Masalah umum yang mejadi fokus penelitian adalah sebagian pelanggan kurang puas dengan pelayanan. Hasil analisis menunjukan bahwa kualitas pelayanan dan persepsi biaya secara bersama-sama berpengaruh terhadap kepuasan pelanggan. Berdasarkan output persamaan pertama, uji hipotesis menunjukan bahwa F-hitung>F tabel ( 9,119>3,11) atau signifikansi hitung< alfa ( 0,000<0,05). Pada output persamaan kedua F-hitung>F-tabel (6,951>3,11 atau signifikansi hitung< alfa ( 0,000<0,05) berarti ada pengaruh secara simultan ketika ada variabel moderasi. Output dari hasil analisis persamaan kedua menunjukan bahwa nilai signifikansi sebesar 0,128>alfa 0,05 berarti variabel persepsi biaya (moderasi) tidak berpengaruh terhadap kepuasan pelanggan. Berdasarkan kedua model persamaan tersebut di atas maka dapat disimpulkan bahwa variabel persepsi biaya bukan merupakan variabel moderasi melainkan sebagai variabel independen atau variabel prediktor.
The component composition of the total flavonoid fractions from some <i>Ericaceae</i> family and their effect on the NO-stimulating activity of peritoneal macrophages
Authors: Reshetov Ya. E. , Ligacheva A. A. , Trofimova E. S. , Selivanova N. S. , Krivoshchekov S. V. , Basova E. V. , Sherstoboev E. Yu. , Avdeeva E. Yu. , Kaminsky I. P. , Danilets M. G. , Belousov M. V. 
Published: August 2024

Introduction. Representatives of the Ericaceae family are quite common in Russia and are promising for the creation of new medicines of plant origin. At the same time, only 4 of them are official. The study of biologically active substances and pharmacological activity of Andromeda polifolia L., Chamaеdaphne calyculata (L.) Moench, Ledum palustre L., Empetrum nigrum L. with rich resource reserves is promising.Aim. Comparative study of the composition of total flavonoid fractions from A. polifolia, C. calyculata, L. palustre, E. nigrum and study of their effect on the NO-stimulating activity of peritoneal macrophagesMaterials and methods. The crushed aboveground part (leafy shoots) was previously depigmented with chloroform, treated with 70 % aqueous acetone, then acetone was removed. Flavonoids were extracted with ethyl acetate from the aqueous phase. The identification of flavonoids was carried out by HPLC (UltiMate 3000 chromatograph) according to the coincidence of retention times and spectral characteristics, the calculation of the content was carried out by simple normalization. The effect of the samples on nitric oxide production was studied on macrophages of C57BL/6 mice. Endotoxin control in the samples was carried out using a LAL test and cell incubation in the presence of polymyxin B.Results and discussion. The composition of flavonoid fractions from A. polifolia, C. calyculata, L. palustre and E. nigrum has been studied. 8 phenolic compounds were found in C. calyculata shoots, including isoquercitrin, herbacetin, naringenin and naringin – for the first time for this species. 5 compounds were detected in A. polifolia shoots, including isoquercitrin and herbacetin, for the first time for this species. 5 and 4 compounds were identified in L. palustre and E. nigrum shoots, respectively, while quercetin glycosides are predominant in all samples: isoquercitrin, hyperoside and rutin. The fraction of C. calyculata flavonoids at doses of 1, 5, 10 mcg/ml inhibits the production of nitric oxide by macrophages by 30 %, and E. nigrum flavonoids at doses of 100 and 200 mcg/ml, on the contrary, enhance the production of nitrites by macrophages by 33 and 37 %, respectively.Conclusion. A comparative study of the composition of total flavonoid fractions from A. polifolia, C. calyculata, L. palustre, and E. nigrum, which are capable of activating both M1 and M2 polarization of peritoneal macrophages in mice, has been conducted, which requires further in-depth study. The flavonoids C. calyculata and E. nigrum are promising for further study.
DEVELOPMENT A DAILY NUTRITIONAL ADEQUACY BALANCE IDENTIFICATION SYSTEM AS AN EFFORT TO PREVENT MALNUTRITION
Authors: Izzah Abidatul , Swanjaya Daniel , Eliyen Kunti 
Published: August 2024

Malnutrition is a deficiency, excess or imbalance in a person's energy and nutritional intake. Malnutrition can occur when a person has too much or too little food and important nutrients in their body. The Ministry of Health, Indonesia, has campaigned for food consumption that complies with balanced nutrition guidelines under the slogan "Isi Piringku". However, the guidelines regarding this matter are still not properly understood by the public. Even if implemented, the nutritional levels contained in one portion of food consumed cannot yet be measured. Thus, to identify the fulfillment of balanced nutritional, a device is needed to easily detect how much calories is consumed. Therefore, this research aims to develop a system which can identify whether the portion of food consumed meets balanced nutrition or not. It is developed in Django framework, Python programming language, and MySQL database. It has been evaluated using black box testing, white box testing, and system usability scales. The result shows that all system requirements have been run well. Meanwhile, system usability testing result shows that the identification system has been tested with a score of 82 and categorized in Excellent.
ANALISIS PENGARUH LABEL HALAL DAN FOOD DRUG ADMINISTRATION TERHADAP MINAT BELI SANTRIWATI
Authors: Sobaroh Lutfia , Sopingi Imam , Santoso Rohmad Prio 
Published: August 2024

Penelitian ini bertujuan untuk menginvestigasi pengaruh label halal dan sertifikasi dari Food and Drug Administration (FDA) pada produk kosmetik terhadap minat beli santriwati. Label halal menjadi indikator penting bagi konsumen Muslim dalam memastikan produk yang konsumsi sesuai dengan hukum syariah, sementara sertifikasi FDA memberikan jaminan bahwa produk telah memenuhi standar keamanan dan kesehatan. Santriwati sebagai konsumen memiliki kebutuhan dan preferensi khusus dalam memilih produk kosmetik yang sesuai dengan keyakinan dan nilai-nilai agamanya. Label halal dan sertifikasi FDA dianggap sebagai faktor penting yang memengaruhi keputusan pembelian. Metode penelitian ini menggunakan pendekatan Kuantitatif dengan teknik Purposive sampling dengan jumlah sampel 155 responden. Data yang terkumpul dianalisis menggunakan regresi linear berganda. Hasil penelitian menunjukkan secara parsial maupun simultan label halal dan food and drug administration mempengaruhi terhadap minat beli santriwati. Hal ini menunjukkan pentingnya produsen kosmetik untuk mempertimbangkan label halal dan sertifikasi FDA sebagai strategi pemasaran yang efektif dalam menarik minat beli dari konsumen santriwati.
Risk Factors of Metabolic Syndrome Among Nurses Hospital Banten, Indonesia
Authors: Yulistriani Anisa , Rayasari Fitrian , Munaya Munaya , Jumaiyah Wati , Abriyanti Rika Mustika 
Published: August 2024

Aims: This study was to determine the prevalence of metabolic syndrome and its associated factors among nurses in Banten.
Methods: The cross-sectional design of this particular type of quantitative correlation study. A total of 102 respondents were comprised of samples selected using random sampling. Variabel aktivitas fisik diidentifikasi menggunakan APARQ (Adolescent Physical Activity Recall Questionnaire) dan Stres diidentifikasi menggunakan DASS 21. Metabolic indicators include hypertension, Obesity, cholesterol, and diabetes. Data analysis used logistic regression.
Result: The prevalence of metabolic syndrome among nurses was 16.7%. Older age (p=0.006), smoking (p=0.008), and stress (p=0.000) were significantly associated with metabolic syndrome. While gender and exercise were not significantly associated with metabolic syndrome.
Conclusion: smoking and stress were the major modifiable risk factors of metabolic syndrome among nurses. Campaigns and prevention of healthy behavior are crucial even among healthcare professionals.
Characterization of genes and proteins involved in the absorption of long-chain fatty acids in the gastrointestinal tract of cattle
Authors: Hentz Fernanda , Batistel Fernanda 
Published: August 2024

IntroductionDietary fatty acids play a pivotal role in energy metabolism and various physical functions. However, the molecular mechanisms underlying the absorption of long-chain fatty acids (LCFA) in ruminant animals remain poorly understood. To address this gap, we investigated the occurrence and distribution of genes and proteins previously characterized in nonruminant models within the gastrointestinal tract of cattle.MethodsTissue samples from the rumen, descending duodenum, proximal jejunum, medial jejunum, distal jejunum, and distal ileum were collected at slaughter from eight Holstein steers. RT‒PCR and capillary electrophoretic-based chemiluminescence were used to determine the mRNA and protein levels of genes and proteins involved in the uptake, activation, intracellular trafficking, re-esterification, and lipoprotein assembly of LCFA.Results and discussionMeasurable mRNA levels were found for 38 genes involved in the intestinal absorption of LCFA in all examined sections of the bovine gastrointestinal tract. The mRNA abundances of all genes were greater in the intestinal sections than in the rumen sections (p &lt; 0.05). At the protein level, the expression of nine key transporters and enzymes, namely, CD36, SLC27A4, ACSL1, FABP1, FABP2, DGAT1, MTP, Apo-AI, and ACAT2, was detected in most of the intestinal sections. The distribution profile of these proteins in the small intestine suggested a prominent role for protein-mediated absorption of LCFA in the proximal and distal intestine in cattle. The low expression levels of most proteins in the rumen suggest little absorption of LCFA at this location in cattle. Overall, the findings from this study support the presence, in cattle, of genes and proteins involved in the intestinal absorption of LCFA described in models of nonruminants. Identifying the proteins involved in the absorption of LCFA in the small intestine is the first step in understanding how the expression of these proteins influences the capacity of the small intestine to absorb fatty acids in cattle.
Association between serum methylmalonic acid and chronic kidney disease in adults: a cross-sectional study from NHANES 2013-2014
Authors: Zhang Zufa , Lv Long , Guan Sheng , Jiang Fengze , He Danni , Song Hongxuan , Sun Weibing , Jiang Sixiong , Tian Feng 
Published: August 2024

IntroductionChronic kidney disease(CKD) is a global medical problem. Serum methylmalonic acid(MMA) is a serum marker associated with many diseases. This study aimed to investigate the association between MMA and CKD.MethodsData from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 were downloaded and analyzed. The association between MMA and CKD was confirmed by using multiple logistic regression modeling. The smooth curve fitting method was used to investigate the nonlinear relationship between them. Subgroup analyses and interaction tests were used to verify the stability of the association between different subgroups. Threshold effect analysis was used to determine the optimal control point for MMA.ResultsThere was a unique W-shaped nonlinear relationship between MMA and the risk of CKD, with a positive correlation between them (OR=1.66,95% CI:1.27, 2.17; P=0.0002). As the stage of CKD progressed, MMA levels increased. Age, hypertension, and serum vitamin B12 had significant influences on the association between MMA and the risk of CKD.ConclusionOur findings revealed that serum MMA accumulation was positively associated with the risk of CKD. Serum MMA level may be a novel index to predict the development and course of CKD. This study may help in the early identification of people at risk for chronic kidney disease and provide new ideas and approaches for prevention and treatment.