bluuebunny/crossref_metadata_2025_split huggingface dataset:
The relationship between overparenting and young children’s problem behaviors in China: a moderated mediation model
Authors: Wang Yingjie , Yao Kemeng , Yao Yijie , Xia Qianqian , Li Yan 
Published: August 2024

Abstract

Problem behaviors are prevalent during the preschool stage and have significant adverse effects on children's future social and academic adjustment. Overparenting represents a crucial familial factor influencing young children's problem behaviors, so it is important to investigate the underlying mechanisms through which overparenting impacts the problem behaviors of young children. A total of 430 young children (Meanage =5.43 years, SD = 1.19) and their parents (Meanage=35.34 years, SD = 4.58) participated in this study. Parents filled the Overparenting Scale, Parent-Child Attachment Scale, Social Competence and Behavior Evaluation and Child Behavior Questionnaire. The results showed that (1) There was a significant positive correlation between parental overparenting and young children’s problem behaviors; (2) Parent-child attachment played a mediating role between parental overparenting and young children’s problem behavior; (3) Children’s negative affect temperament moderated the latter half path of the mediation model, that is, at high levels of negative affect, overparenting has a stronger effect on children’s problem behaviors through parent-child attachment. The results provided the basis for the intervention to alleviate the young children’s problem behavior from the perspective of parenting and child’s temperament.
Predictors of dropout from abemaciclib therapy in patients with breast cancer: a multicenter retrospective cohort study
Authors: Kataoka Noriaki , Hata Takeo , Hosomi Kouichi , Hirata Atsushi , Ota Ryosuke , Nishihara Masami , Kimura Kosei , Iwamoto Mitsuhiko , Ashida Akira , Neo Masashi 
Published: August 2024

Abstract

Objective: This study explored the predictors of dropping out from abemaciclib therapy, a cyclin-dependent kinase 4 and 6 inhibitor, in patients with breast cancer.
Material and Methods: Between November 2018 and March 2023, 147 patients with breast cancer treated with abemaciclib at Osaka Medical and Pharmaceutical University Hospital and Kindai University Nara Hospital were included. The exclusion criteria were as follows: lack of blood testing within 2 weeks prior to starting abemaciclib therapy, transfer to another facility after the commencement of abemaciclib therapy, and discontinuation of abemaciclib therapy due to the diagnosis of another cancer. The duration from the initiation of abemaciclib to dropout for any reason and to temporary suspension or dose reduction due to adverse events were analyzed as outcome variables using multivariate Cox regression analysis.
Results: Baseline weight <54 kg, bone metastases, and hemoglobin level ≤12.4 g/dL were independent predictors of dropout for any reason. The main adverse events leading to dropout were liver enzyme elevation and gastrointestinal symptoms. Additionally, focusing on the adverse event of abemaciclib, a baseline weight <54 kg was an independent predictor of temporary suspension or dose reduction due to adverse events. The most common adverse events leading to temporary suspension or dose reduction were neutropenia and diarrhea.
Conclusion: Patients with lower body weight are more susceptible to the adverse events of abemaciclib, increasing their risk of treatment dropout. In such patients, strict monitoring of adverse events and consideration of more frequent medical visits are necessary from the start of abemaciclib therapy.
An Ultrasound Image Segmentation Method for Thyroid Nodules Based on Dual-Path Attention Mechanism-Enhanced UNet++
Authors: Dong Peizhen , Zhang Ronghua , Li Jun , Liu Changzheng , Liu Wen , Hu Jiale , Yang Yongqiang , Li Xiang 
Published: August 2024

Abstract

Purpose: This study aims to design an auxiliary segmentation model for thyroid nodules to increase diagnostic accuracy and efficiency, thereby reducing the workload of medical personnel.
Methods: This study proposes a Dual-Path Attention Mechanism (DPAM)-UNet++ model, which can automatically segment thyroid nodules in ultrasound images. Specifically, the model incorporates dual-path attention modules into the skip connections of the UNet++ network to capture global contextual information in feature maps. The model's performance was evaluated using Intersection over Union (IoU), F1_score, accuracy, etc. Additionally, a new integrated loss function was designed for the DPAM-UNet++ network.
Results: Comparative experiments with classical segmentation models revealed that the DPAM-UNet++ model achieved an IoU of 0.7451, an F1_score of 0.8310, an accuracy of 0.9718, a precision of 0.8443, a recall of 0.8702, an Area Under Curve (AUC) of 0.9213, and an HD95 of 35.31. Except for the precision metric, this model outperformed the other models on all the indicators and achieved a segmentation effect that was more similar to that of the ground truth labels. Additionally, ablation experiments verified the effectiveness and necessity of the dual-path attention mechanism and the integrated loss function.
Conclusion: The segmentation model proposed in this study can effectively capture global contextual information in ultrasound images and accurately identify the locations of nodule areas. The model yields excellent segmentation results, especially for small and multiple nodules. Additionally, the integrated loss function improves the segmentation of nodule edges, enhancing the model’s accuracy in segmenting edge details.
Evaluation of Risk Factors for Recurrent Ventriculoperitoneal Shunt Infections in Adult
Authors: Elgormus Neval , Dogu Huseyin , Okuyan Omer , Bozkurt Fatma , Senyigit Abdulhalim , Uzun Hafize 
Published: August 2024

Abstract

Objective: The objective of this paper is to evaluate demographic, clinical, laboratory and microbiological features of ventriculoperitoneal shunt (VPS) infections in this 13 year retrospective study. VPS-related bacterial agents and their antibiotic sensitivity were also investigated in single VPS (SVPS) and recurrent VPS (RVPS) infections.
Methods: The study included 110 patients with SVPS infection and 55 patients with RVPS infection.
Results: In patients who developed multiple infections, gram-negative organisms were the most predominant (60%, 54/90). Resistance rates were 85.2% for third generation cephalosporins, 83.3% for Piperacillin-Tazobactam, and 10.4% for Carbapenem's. Forty-nine % of patients in the SVPS and 84.4% in the RVPS infection group were treated with combinations of carbapeneme. Central nervous system (CNS) tuberculosis as the etiology of hydrocephalus, short duration of antibiotics used for treatment, high cerebrospinal fluid (CSF) protein and blood C-reactive protein (CRP) levels, and prolonged use of prophylactic antibiotics was found related to increased rate of recurrent infection occurrence. Two-stage shunt change decreased the risk of recurrent infections.
Conclusions: VPS infection may be life-threating and its management rucial. Rational and appropriate use of antibiotics and treatment methods according to the algorithms can reduce recurrent infections. Gram-negative predominant bacterial colonization and its carbapenem sensitivity in RVPS infection has to be kept in mind to manage the infection effectively.
Prognosis of patients with breast cancer who underwent breast-conserving surgery using a 3D-printed surgical guide after neoadjuvant chemotherapy
Authors: Kim Ah Yoon , Lee Sae Byul , Yoo Tae Kyung , Kim Ji Sun , Chung Il Yong , Kim Hee Joung , Lee Jong Won , Son Byung Ho , Jeong Jae Ho , Lee Hee Jin , Kim Nam kug , Ko BeomSeok 
Published: August 2024

Abstract

In breast-conserving surgery (BCS), clear resection margins are crucial to prevent recurrence. Accurate imaging is vital for precise BCS, with MRI being the most accurate. However, MRI has limitations in identifying the exact extent of breast cancer in patients who have undergone neoadjuvant chemotherapy (NACT). A 3D-Printed Breast Surgical Guide (3DP-BSG) can address this issue by effectively pinpointing cancer extent in NACT patients, thus enhancing surgical accuracy. This retrospective single-institution cohort study focused on female patients diagnosed with invasive breast cancer who underwent NACT. Between November 2015 and October 2021, patients received BCS with the aid of a 3DP-BSG. Personalized 3DP-BSG targeted tumors by tracking changes in breast and tumor anatomy on MRI before and after NACT. 203 patients with invasive breast cancer were enrolled in the study. According to exclusion criteria, 197 patients were analyzed. The median follow-up period was 35.3 months (range: 2.2–96.8 months). 3 patients (1.5%) had positive resection margins. During the follow-up period, 17 patients (8.6%) experienced recurrence, with one patient (0.5%) confirmed local recurrences. The application of MRI-based 3DP-BSG is effective in achieving low positive margins and local recurrence in patients undergoing BCS after NACT, offering a promising approach for improving surgical outcomes.
A novel ATP-binding cassette protein (NoboABCG1.3) p lays a vital role in the proliferation of Nosema bombycis
Authors: He Shaogang , Zheng Shiyi , Zhu Honglin , Hu Yuanke , Yu Bin , Wei Junhong , Pan Gu oqing , Zhou Zeyang , Li Chunfeng 
Published: August 2024

Abstract

ATP-binding cassette (ABC) transporter proteins, one of the largest families of membrane transport proteins, participate in almost all biological processes and widely exist in living organisms. Microsporidia are intracellular parasites, they can reduce crop yields and pose a threat to human health. The ABC proteins are also present in microsporidia and plays a critical role in their proliferation and energy transport. In this study, a novel ABC transporter protein of Nosema bombycis named NoboABCG1.3 was identified. The NoboABCG1.3 protein is comprised of 640 amino acids, which contains six transmembrane domains and one nucleotide-binding domain. After N. bombycis infection of cells or tissues, quantitative reverse transcription polymerase chain reaction analysis revealed a progressive elevation in the transcript levels of NoboABCG1.3. Downregulation of NoboABCG1.3 expression significantly inhibited N. bombycis proliferation. Subsequently, a transgenic cell line stably expressing an interfering fragment of NoboABCG1.3 was established, which exhibited extreme inhibition on the proliferation of N. bombycis. These findings indicate that NoboABCG1.3 plays a crucial role in the proliferation of N. bombycis and holds promise as a target for developing N. bombycis-resistant silkworms.
Ascites-derived EpCAM+/CD45+ ovarian cancer stem cells unveil potential therapeutic targets
Authors: Meigooni Mohammad Reza Tayebizadeh , Kharkeshi Mahboubeh Safari , Daneshvari Sadra , Montazeri Hesam , Hossein Ghamartaj 
Published: August 2024

Abstract

Ascites-derived ovarian cancer stem cell (OCSC) populations may originate from the fallopian tube epithelium (FTE) or ovarian surface epithelium (OSE). Additionally, EpCAM/CD45 dual-positive OCSCs (DpOCSCs) may also result from the other origin. The distinctions between these two OCSC populations are not thoroughly understood. This study examines the transcriptome analysis of ascites-derived DpOCSC populations compared to ascites-derived OCSC populations with FTE/OSE origins. We observed that upregulated genes in DpOCSCs are primarily associated with inflammatory pathways, such as NFκB, TNF, Toll-like receptor, and IL-17 signaling pathways. Moreover, 14 out of 28 identified DpOCSCs-related hub genes were TCGA-validated at mRNA levels, among which SYK, CD74, and LCP1 were also validated at protein levels using the UALCAN dataset. SYK, in particular, stood out, displaying a noteworthy association with decreased progression-free survival. Notably, we found a significant positive correlation between DpOCSCs-related hub genes and immune checkpoint proteins, as well as with infiltrating immune-suppressive cells. Further examination of their relations with clinico-pathological features revealed that seven out of fourteen TCGA-validated hub genes were significantly linked to lymphatic and venous invasion, which were transcriptionally regulated by Wnt/β-catenin signaling pathway. Furthermore, SYK was significantly related to new neoplasm events type and primary therapy outcomes success. In conclusion, our findings suggest that hub genes associated with DpOCSC populations in ascites could be potential therapeutic targets due to their involvement in tumor progression and invasiveness.
Scrutinizing the LCC Hypothesis in ASEAN-5: An Innovative Exploration Integrating Energy Intensity, Global Trade Dynamics, and Financial Inclusion Using DKSE and Quantile Regression
Authors: Ridwan Mohammad , Aspy Nazhat Nury , Mahjabin Tasfia , Eleais Md. , Shaari Mohd Shahidan , Ridzuan Abdul Rahim , P Jaheer Mukthar K , Shah Mohd Asif 
Published: August 2024

Abstract

This study investigates how economic growth, energy intensity, financial inclusion, and trade globalization impact the load capacity factor in the ASEAN-5 region. Using data from 2000 to 2022 from reputable databases, the study analyzed the load capacity curve (LCC) hypothesis through comprehensive statistical analysis. Several diagnostic tests, such as cross-sectional dependence, slope homogeneity, unit root, and cointegration, to select a suitable long-run estimation model were conducted. The study utilized the Driscoll-Kraay standard error (DKSE) approach to address identified issues like cross-sectional dependence, heterogeneity, and unit root problems. DKSE estimation showed that the LCC hypothesis was not present in the ASEAN-5 region. It is worth noting that an inverted-U-shaped relationship between per capita income and the load capacity factor was found, emphasizing the complexity of economic dynamics in the region. Furthermore, the analysis revealed a strong correlation between energy intensity and the load capacity factor, with trade globalization having a significant negative effect. Surprisingly, financial inclusion did not show a significant correlation with the load capacity factor, highlighting the intricate role of financial accessibility in economic performance. To enhance the strength of the DKSE estimation, the study also utilized quantile regression analysis, which supported the results of the DKSE approach. The study confirmed that the LCC hypothesis is not applicable in the ASEAN-5 region and offered a more detailed analysis of the varying effects of energy intensity and trade globalization at different levels. Conclusively, this study provides valuable insights into the complex relationships among economic growth, energy intensity, financial inclusion, and trade globalization in the ASEAN-5 region. A thorough analytical approach enhances comprehension of sustainable development and economic resilience in the region, guiding policy decisions and future research efforts.
JEL: Q43, G21, F14, D24, F15
Windthrow disturbance impacts soil biogeochemistry and bacterial communities in a temperate forest
Authors: Waring Bonnie , Lancastle Lena , Bell Thomas , Bidartondo Martin I. , García-Díaz Pablo , Lambin Xavier , Vanguelova Elena , Windram Francis A. 
Published: August 2024

Abstract

Aims.
Forests across the world are subject to disturbance via wind, wildfire, and pest and disease outbreaks. Yet we still have an incomplete understanding of how these stressors impact forest biota - particularly the soil microbes, which govern forest carbon and nutrient cycling.
Methods.
Here, we investigated the impact of windstorms on soil bacterial communities in Kielder Forest, a temperate coniferous forest in the north of England. Within ten individual sites, defined by common stand composition and topography, we established 50 m2 plots in undisturbed stands, and in nearby stands that were moderately and/or severely disturbed by windthrow. Soils were sampled within each of the 22 study plots, and analysed for changes in carbon and nitrogen content, pH, root biomass, and bacterial community structure. We separately sequenced bacteria from bulk soils, rhizosphere soils, and root tissues to assess whether disturbance impacts varied based on the proximity of microbiota to tree roots.
Results.
Less than a year after the storm, we found that the most severely disturbed stands had lower canopy cover, lower soil carbon content, higher soil pH, and a smaller fine root biomass than the undisturbed stands. Disturbance also impacted bacterial community beta-diversity, but the effects were subtle and did not vary among assemblages in bulk vs. rhizosphere soils.
Conclusions.
Impacts of aboveground disturbance on soil biogeochemistry can be significant, but soil bacterial communities are relatively well-buffered against these changes. However, altered patterns of root growth and carbon cycling may have longer-term implications for forest recovery after windthrow disturbances.
Fecal metabolomics to understand intestinal dysfunction in male dairy beef calves at arrival to the rearing farm
Authors: Bassols Anna , Amigó Núria , Pérez-Rodado Marc , Saco Yolanda , Peña Raquel , Pato Raquel , Pisoni Lucia , Devant Maria , Martí Sònia 
Published: August 2024

Abstract

Fecal biomarkers are becoming an important analytical tool since feces are in direct contact with the inflamed intestine and site for the gut microbiome. The objective of this study was the identification of potential fecal biomarkers by means of 1H-NMR to evaluate management of male dairy beef calves. Holstein calves were subjected to a protocol aimed to simulate real conditions of the dairy beef market. Three groups were studied: Control (CTR: high colostrum, no transport, milk replacer), LCMR (low colostrum, transport, milk replacer) and LCRS (low colostrum, transport, rehydrating solution). Fecal lactoferrin was determined as marker of intestinal inflammation, and metabolomic profiling was performed in feces collected the day after arrival to the farm. 41 polar and 10 non-polar metabolites were identified, of which proline, formate and creatine increased in the LCRS group, whereas butyrate and uracil decreased. Less differences were found in non-polar metabolites. Multivariate analysis indicated that most differences are found between the LCRS group and the others. In conclusion, this study indicates that feed restriction has a more important effect at this age than colostrum uptake and transport. These results should help to identify robust fecal biomarkers to assess calf intestinal health and improve management protocols.
Modeling and analysis of hybrid bonded-bolted joining in large-scale aircraft assembly
Authors: Eliseev Artem , Lupuleac Sergey , Shinder Julia , Grigor'ev Boris , Khashba Valeriia 
Published: August 2024

Abstract

Hybrid Bonded-Bolted (HBB) joining is a common method used in aircraft assembly, particularly for critical junctions such as the wing-to-fuselage joint, to ensure both quality and durability. Accurate simulation of HBB joining presents a significant challenge, as it requires proper description of contact interaction of the assembled parts, the flow of adhesive used for bonding and their mutual influence. In this paper, the process of HBB joining of the upper wing panel and fuselage of a commercial aircraft is simulated. The utilized mathematical model is comprehensive in several ways. Firstly, it covers all most important physical phenomena determining the intermediate and final result of the assembly process, notably including the two-way fluid-structure interaction and a presence of a free surface in the fluid part. Secondly, the finite element model of the joint has dimensions and level of detail comparable to models used in industrial applications. Finally, the complete sequence of assembly stages is reproduced during the simulation, including installation of temporary fasteners and their replacement by permanent ones. The paper focuses on investigating the problem of permanent fasteners loosening, a critical issue in aircraft assembly. The state-of-the-art aircraft assembly technologies typically include requirements intended to prevent significant loosening of permanent fasteners by the end of the assembly process. The validity of these requirements is studied using a series of numerical tests with specially developed simulation tool.
Explicating the fertilizer potential of anaerobic digestate on soil quality and growth performances of Solanum lycopersicum var. Kashi Aman
Authors: Singh Rajeev Pratap , Gautam Meenu , Vaish Barkha , Suhani Ibha , Srivast Vaibhav 
Published: August 2024

Abstract

Application of anaerobic digestates (ADg(s)) from organic wastes as bio-fertilizer in agricultural field is economically viable and environmentally sustainable alternative. The study aimed to utilize ADg(s) (25, 50, 75 and 100% w/w) from the organic proportion of flower-waste (FW), sewage-sludge (SS) and municipal solid wastes (OFMSW) as soil amendment to investigate soil nutrient status and growth performances of tomato (Solanum lycopersicum var. Kashi Aman). Organic carbon, nitrogen, phosphorous, exchangeable Na, K and Ca ions, and enzymatic activities were increased with increase in ADg(s) amendment in soil with relatively higher increase under OFMSW amendment. Metal contents in the soil amended with ADg(s) were in the order, Fe > Zn > Mn > Cu > Ni > Cr > Cd and their contents increased with increasing OFMSW, SS and FW. Plant biomass and fruit-yield were higher under all ADg(s) amendments compared to the control, with maximum yield under 100% SS. Contents of Fe, Zn, Mn, Cu, Cr and Pb in the entire plant were positively correlated with the yield under all ADg(s) amendments. Based on translocation and bioconcentration factors, tomato was found to be efficient in accumulation of metals except Cd. Content of Ni, Mn, Cu, Zn and Cd in the fruit were though below FAO/WHO limit, but Fe, Cr and Pb contents were above the limit. Hence, utilization of ADg(s) from OFMSW, SS and FW as fertilizer although improved the soil fertility and tomato yield, but due to high contents of Fe, Cr and Pb in the fruit, cultivation of tomato is not suggested.