bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrated Service Areas: An Innovative Approach to Housing, Services and Supports for Older Persons Ageing in Place
Authors: Singelenberg Jeroen , Stolarz Holger , McCall Mary E. 
Published: January 2014

ABSTRACTAs the number of older people increases, the need for housing and services grows. A unique project, started in northern Europe, provides a platform for sharing best practices, within appropriate cultural contexts, for supportive local housing for a range of needs. These Integrated Service Areas (ISAs) provide a range of co‐located and locally integrated services in small communities. This paper presents preliminary research that points towards greater satisfaction, feelings of security and longer housing independence among those living in ISAs compared with other elders. We argue that ISAs represent a useful example of possible housing arrangement for older people and that similar projects in different cultures could be implemented in order to improve the quality of life and housing for older persons. Copyright © 2013 John Wiley & Sons, Ltd.
Expansion and malapposition characteristics after bioresorbable vascular scaffold implantation
Authors: Brown Adam J. , McCormick Liam M. , Braganza Denise M. , Bennett Martin R. , Hoole Stephen P. , West Nick E.J. 
Published: January 2014

ObjectivesThis study sought to investigate the postdeployment expansion and malapposition characteristics of the bioresorbable vascular scaffold (BVS) in real‐world practice.BackgroundThe material construct of the BVS precludes overexpansion, with consequent potential for scaffold underexpansion and malapposition. In metallic stents, these features are associated with an increased risk of adverse events, including stent thrombosis. The postdeployment characteristics of the BVS are yet to be described outside clinical trials, where implantation occurred in straightforward lesion subsets.MethodsData from 25 patients undergoing BVS implantation were analyzed. Optical coherence tomography (OCT) was performed both before and after intervention to assess plaque composition, scaffold expansion and strut apposition. Manufacturer's compliance charts were used to predict expected minimal scaffold diameter and area.ResultsOCT pullback (522.2 mm) was analyzed. Overall, BVS achieved 82.5 ± 8.7 and 79.8 ± 12.3% of predicted minimal stent diameter and cross‐sectional area (SCA), respectively, with expansion reduced in middle third of the scaffold (central SCA 76.7 ± 10.9% vs. noncentral SCA 81.5 ± 12.7%, P < 0.0001). Improved measures of SCA were observed with 1:1 balloon:vessel predilatation (1:1 PreD 82.8 ± 9.5% vs. No 1:1 PredD 78.6 ± 13.0%, P < 0.0001). Seven thousand six hundred scaffold struts were identified, of which 470 (6.18%) were malapposed. In fibrocalcific (FCa) plaques, malapposition was observed more frequently (FCa 44.4% vs. Other plaques 7.5%, P < 0.001) and at a greater distance from the vessel wall (FCa 0.17 ± 0.10 mm vs. Other plaques 0.14 ± 0.08 mm, P = 0.002).ConclusionsIn this study, BVS expansion was significantly improved by 1:1 PreD, while increased rates of malapposition was associated with FCa plaques. © 2014 Wiley Periodicals, Inc.
A semi‐mechanistic model to characterize the pharmacokinetics and pharmacodynamics of brodalumab in healthy volunteers and subjects with psoriasis in a first‐in‐human single ascending dose study
Authors: Salinger David H. , Endres Christopher J. , Martin David A. , Gibbs Megan A. 
Published: January 2014

AbstractPharmacokinetic‐pharmacodynamic (PK‐PD) modeling can provide a framework for quantitative “learning and confirming” from studies in all phases of drug development. Brodalumab is a human monoclonal antibody (IgG2) targeting the IL‐17 receptor A that blocks signaling by cytokines thought to play a central role in the pathogenesis of psoriasis (IL‐17A, IL‐17F, and IL‐17A/F). We used semi‐mechanistic modeling of single dose, first‐in‐human data to characterize the exposure‐response relationship between brodalumab and the Psoriasis Area and Severity Index (PASI) in a Phase 1 clinical trial. Fifty‐seven healthy volunteers and 25 subjects with moderate to severe psoriasis received single intravenous or subcutaneous administration of placebo or brodalumab (7–700 mg). A two‐compartment model with parallel linear and nonlinear (Michaelis–Menten) elimination pathways described brodalumab PK. The PK‐PASI relationship was characterized by linking a signaling compartment with an indirect response model of psoriatic plaques, where signaling suppressed plaque formation. The concentration of half‐maximal inhibition IC50 was 2.86 µg/mL (SE: 50%). The endogenous psoriatic plaque formation rate of 0.862 (SE: 40%) PASI units/day was comparable with literature precedent. Despite the small sample size and single administration data, this semi‐mechanistic modeling approach provided a quantitative framework to inform design of dose‐ranging Phase 2 studies of brodalumab in psoriasis.
GPU implementation of a parallel two‐list algorithm for the subset‐sum problem
Authors: Wan Lanjun , Li Kenli , Liu Jing , Li Keqin 
Published: January 2014

SUMMARYThe subset‐sum problem is a well‐known non‐deterministic polynomial‐time complete (NP‐complete) decision problem. This paper proposes a novel and efficient implementation of a parallel two‐list algorithm for solving the problem on a graphics processing unit (GPU) using Compute Unified Device Architecture (CUDA). The algorithm is composed of a generation stage, a pruning stage, and a search stage. It is not easy to effectively implement the three stages of the algorithm on a GPU. Ways to achieve better performance, reasonable task distribution between CPU and GPU, effective GPU memory management, and CPU–GPU communication cost minimization are discussed. The generation stage of the algorithm adopts a typical recursive divide‐and‐conquer strategy. Because recursion cannot be well supported by current GPUs with compute capability less than 3.5, a new vector‐based iterative implementation mechanism is designed to replace the explicit recursion. Furthermore, to optimize the performance of the GPU implementation, this paper improves the three stages of the algorithm. The experimental results show that the GPU implementation has much better performance than the CPU implementation and can achieve high speedup on different GPU cards. The experimental results also illustrate that the improved algorithm can bring significant performance benefits for the GPU implementation. Copyright © 2014 John Wiley & Sons, Ltd.
HIF‐1α Expression as a Protective Strategy of HepG2 Cells Against Fatty Acid‐Induced Toxicity
Authors: Yoo Wonbaek , Noh Kyung Hee , Ahn Jae Hee , Yu Ji Hee , Seo Ji A. , Kim Sin Gon , Choi Kyung Mook , Baik Sei Hyun , Choi Dong Seop , Kim Tae Woo , Kim Hyo Joon , Kim Nan Hee 
Published: January 2014

ABSTRACTFree fatty acid‐induced lipotoxicity via increased endoplasmic reticulum (ER) stress and hepatocyte apoptosis is a key pathological mechanism of non‐alcoholic steatohepatitis. A role of hypoxia‐inducible factor 1α (HIF‐1α) in this process has been suggested, but direct evidence is lacking. Here, we used HepG2 cells as a model to study whether HIF‐1α can reduce palmitic acid‐induced lipotoxicity and ER stress. In HepG2 cells treated with 500 µM palmitic acid, HIF‐1α expression increased transiently, the decline was associated with increased cleaved caspase‐3 expression. Overexpression and knockdown of HIF‐1α decreased and exacerbated, respectively, palmitic acid‐induced lipoapoptosis. The overexpression also blunted upregulation of the ER stress markers, C/EBP homologous protein (CHOP) and chaperone immunoglobulin heavy chain binding protein (Bip), while the knockdown increased the level of CHOP. In line with this, CHOP promoter activity decreased following HIF‐1α binding to the CHOP promoter hypoxia response element. These results indicate that hepatocyte lipotoxicity is associated with decreased HIF‐1α expression. It also suggests that upregulation of HIF‐1α can be a possible strategy to reduce lipotoxicity in non‐alcoholic fatty liver disease. J. Cell. Biochem. 115: 1147–1158, 2014. © 2014 Wiley Periodicals, Inc.
Removal of fumaric acid from simulated and real fermentation broth
Authors: Staszak Katarzyna , Woźniak Marta , Sottek Magdalena , Karaś Zofia , Prochaska Krystyna 
Published: January 2014

AbstractBACKGROUNDOne of the most popular methods of glycerol utilisation involves its bioconversion to low‐molecular organic compounds such as polyoles or organic acids. Because of the presence of contaminants in the post‐fermentation broth, including left‐over glycerol, small amounts of proteins, inorganic salts and some organic acids formed in the process of fermentation (mainly acetate, formic and lactic acids), the success of bioconversion is determined by the process of purification. In the study presented the usefulness of nanofiltration with the use of ceramic membranes for concentration and separation of fumaric acid from glycerol was evaluated.RESULTSIt was found that the retention of fumaric salt increased strongly with increasing pH of the feed solution (depending on the degree of dissociation). The retentions of uncharged compounds, i.e. fumaric acid or glycerol were lower than 2%, irrespective of the initial concentration of the solution to be filtered.CONCLUSIONThe results obtained showed that nanofiltration can be considered as one of the purification steps in the process of recovery of salts of organic acids from a fermentation broth containing glycerol. © 2014 Society of Chemical Industry
Effect of cultivation line and peeling on food composition, taste characteristic, aroma profile, and antioxidant activity of Shiikuwasha (Citrus depressa Hayata) juice
Authors: Asikin Yonathan , Fukunaga Hibiki , Yamano Yoshimasa , Hou De‐Xing , Maeda Goki , Wada Koji 
Published: January 2014

AbstractBACKGROUNDShiikuwasha (Citrus depressa Hayata) juice from four main cultivation lines subjected to two peeling practices (with or without peeling) were discriminated in terms of quality attributes, represented by sugar and organic acid composition, taste characteristic, aroma profile, and antioxidant activity.RESULTSShiikuwasha juice from these lines had diverse food compositions; ‘Izumi kugani’ juice had lower acidity but contained more ascorbic acid than that of other cultivation lines. The composition of volatile aroma components was influenced by fruit cultivation line, whereas its content was affected by peeling process (20.26–53.73 mg L−1 in whole juice versus 0.82–1.58 mg L−1 in flesh juice). Peeling also caused Shiikuwasha juice to be less astringent and acidic bitter and to lose its antioxidant activity. Moreover, the total phenolic and ascorbic acid content of Shiikuwasha juice positively influenced its antioxidant activity.ConclusionEach fruit cultivation line had a distinct food composition, taste characteristic, and aroma profile. Peeling in Shiikuwasha juice production might reduce aftertaste, and thus might improve its palatability. Comprehensive information on the effect of cultivation line and peeling on quality attributes will be useful for Shiikuwasha juice production, and can be applied to juice production of similar small citrus fruits. © 2014 Society of Chemical Industry
Assessment of appalachian region pediatric hearing healthcare disparities and delays
Authors: Bush Matthew L. , Osetinsky Mariel , Shinn Jennifer B. , Gal Thomas J. , Ding Xiuhua , Fardo David W. , Schoenberg Nancy 
Published: January 2014

Objectives/HypothesisThe purpose of this study was to examine the timing of diagnostic and therapeutic services in cochlear implant recipients from a rural Appalachian region with healthcare disparity.Study DesignRetrospective analysis.MethodsCochlear implant recipients from a tertiary referral center born with severe congenital sensorineural hearing loss were examined. Rural status and Appalachian status of their county of origin were recorded. A log‐rank test was used to examine differences in the distributions of time to definitive diagnosis of hearing loss, initial amplification fitting, and cochlear implantation in these children. Correlation analysis of the rural status of each county and the timing of services was assessed.ResultsA total of 53 children born with congenital hearing loss were included in the study (36 from rural counties and 17 from urban/suburban counties). The distribution of weeks after birth to diagnosis (P = .006), amplification (P = .030), and cochlear implantation(P = .002) was delayed in rural children compared with urban children. An analysis factoring in the effect of implementation of mandatory infant hearing screening in 2000 demonstrated a similar delay in rural children for weeks to diagnosis (P = .028), amplification (P=.087), and cochlear implantation (P < .0001).ConclusionsChildren with severe hearing loss in very rural areas, such as Appalachia, may have significant delays in diagnostic and rehabilitative services. Further investigation is warranted to assess causative factors in delays of cochlear implantation and to develop interventions to promote timely diagnosis and care.Level of Evidence3b. Laryngoscope, 124:1713–1717, 2014
Screening of mutations in GNAL in sporadic dystonia patients
Authors: Dufke Claudia , Sturm Marc , Schroeder Christopher , Moll Susanne , Ott Thomas , Riess Olaf , Bauer Peter , Grundmann Kathrin 
Published: January 2014

ABSTRACTBackgroundGNAL mutations have been shown to cause adult‐onset isolated dystonia, a disabling movement disorder characterized by involuntary muscle contractions causing twisting and repetitive movements or abnormal postures.MethodsTo test the frequency of GNAL mutations in a series of 137 German patients with sporadic dystonia patients we used next‐generation sequencing of amplicon‐derived barcoded NexteraXT libraries for the coding exons and adjacent intronic sequences of GNAL.ResultsIn our cohort we identified 1 pathogenic nonsense mutation (c.733C>T, p.R245*) in a patient with cervical dystonia. In a second patient a synonymous coding nonsynonymous variant (c.G252A, p.E84E) was detected, which is predicted to alter a splice site.ConclusionsOur findings further support GNAL as causative gene in adult‐onset isolated dystonia. © 2014 International Parkinson and Movement Disorder Society
MicroRNA‐542‐3p inhibits tumour angiogenesis by targeting Angiopoietin‐2
Authors: He Ting , Qi Feifei , Jia Lin , Wang Shan , Song Nan , Guo Lifang , Fu Yan , Luo Yongzhang 
Published: January 2014

AbstractAngiopoietin‐2 (Angpt2) plays a critical role in angiogenesis and tumour progression. Therapeutic targeting of Angpt2 has been implicated as a promising strategy for cancer treatment. Whereas miRNAs are emerging as important modulators of angiogenesis, regulation of Angpt2 by miRNAs has not been established. Here we firstly report that Ang2 is targeted by a microRNA, miRNA‐542‐3p, which inhibits tumour progression by impairing Ang2's pro‐angiogenic activity. In cultured endothelial cells, miR‐542‐3p inhibited translation of Angpt2 mRNA by binding to its 3′ UTR, and addition of miR‐542‐3p to cultured endothelial cells attenuated angiogenesis. Administration of miR‐542‐3p to tumour‐bearing mice reduced tumour growth, angiogenesis and metastasis. Furthermore, the level of miR‐542‐3p in primary breast carcinomas correlated inversely with clinical progression in primary tumour samples from stage III and IV patients. Together, these findings uncover a novel regulatory pathway whereby an anti‐angiogenic miR‐542‐3p directly targets the key angiogenesis‐promoting protein Angpt2, suggesting that miR‐542‐3p may represent a promising target for anti‐angiogenic therapy and a potential marker for monitoring disease progression. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd
Assembly and Catalytic Properties of Cobalt(II) and Copper(II) Coordination Polymers Based on Bis(imidazole) and Carboxylic Acid Mixed Ligands
Authors: Xiao Shu‐Lin , Liu Li , Ma Pei‐Juan , Cui Guang‐Hua 
Published: January 2014

AbstractTwo CoII/CuII coordination polymers, [Co(bim)(ip)]n (1) and [Cu3(nip)2(OH)(bim)(H2O)]n (2) [bim = bis(imidazol‐1‐yl)methane, H2ip = isophthalic acid and H2nip = 5‐nitroisophthalic acid], were synthesized by reactions of metal acetate with H2ip or H2nip in the presence of bim ligand under hydrothermal conditions. The polymers were characterized by elemental analyses, IR spectroscopy, TGA, XRPD, and single‐crystal X‐ray diffraction. Compound 1 shows a 2D (4, 4) layer structure with CoII ions at the nodes, which is further extended in to a 3D supramolecular network through C–H···π interactions. Compound 2 manifests a four‐connected {Cu5(OH)2}8+ pentameric kernel, which is bridged by bim ligand molecules and two kinds of nip ligands with different coordination modes. This complex also displays a 2D (4, 4) network, which is constructed from pentanuclear CuII clusters as secondary building unit (SBU). In addition, the catalytic properties of the title compounds for the degradation of congo red were investigated.
High Pressure Synthesis of the Cation‐ordered Perovskite 3C1:2‐Ba3NaRu2O9
Authors: Arevalo‐Lopez Angel M. , Senn Mark S. , Skedd Lauren , Attfield J. Paul 
Published: January 2014

AbstractThe new phase 3C1:2‐Ba3NaRu2O9 was synthesized by heating the hexagonal perovskite 6H‐Ba3NaRu2O9 at 900 °C under a pressure of 9 GPa. 3C1:2‐Ba3NaRu2O9 adopts the 1:2 B site‐ordered cubic perovskite type structure [space group P$\bar{3}$m1, cell parameters a = 5.8068(3) and c = 7.0652(5) Å] but a significant cation inversion between Na and Ru sites is found. No magnetic ordering transition is observed down to 2 K and 3C1:2‐Ba3NaRu2O9 displays Pauli paramagnetism indicative of a metallic oxide with strong electron‐electron correlations.
Designing Molecular Flip‐Flops – DFT‐Investigations on the Enantiomerization of Hetero Helicenes
Authors: Alzoubi Basam M. 
Published: January 2014

AbstractEnantiomerization of the heterocyclic compounds PyPhXPhPy, PyXXPhPy, PyXPhXPy and PyXXXPy with furan (X = O), thiophene (X = S), and selenophene (X = Se), were studied by quantum chemical calculations [B3LYP/6‐31G* and MP2(full)/6‐311+G**//B3LYP/6‐31G*]. The activation barriers for the helicene compounds and twist angle decrease in the order PyPhSePhPy > PyPhSPhPy > PySePhSePy > PySeSePhPy > PySPhSPy. Electronic and steric factors of the helicene compounds affect the enantiomerization process and activation energy barrier.
Surgical Task‐Shifting in a Low‐Resource Setting: Outcomes After Major Surgery Performed by Nonphysician Clinicians in Tanzania
Authors: Beard Jessica H. , Oresanya Lawrence B. , Akoko Larry , Mwanga Ally , Mkony Charles A. , Dicker Rochelle A. 
Published: January 2014

AbstractBackgroundLittle is known about the breadth and quality of nonobstetric surgical care delivered by nonphysician clinicians (NPCs) in low‐resource settings. We aimed to document the scope of NPC surgical practice and characterize outcomes after major surgery performed by nonphysicians in Tanzania.MethodsA retrospective records review of major surgical procedures (MSPs) performed in 2012 was conducted at seven hospitals in Pwani Region, Tanzania. Patient and procedure characteristics and level of surgical care provider were documented for each procedure. Rates of postoperative morbidity and mortality after nonobstetric MSPs performed by NPCs and physicians were compared using multivariate logistic regression.ResultsThere were 6.5 surgical care providers per 100,000 population performing a mean rate of 461 procedures per 100,000 population during the study period. Of these cases, 1,698 (34.7 %) were nonobstetric MSPs. NPCs performed 55.8 % of nonobstetric MSPs followed by surgical specialists (28.7 %) and medical officers (15.5 %). The most common nonobstetric MSPs performed by NPCs were elective groin hernia repair, prostatectomy, exploratory laparotomy, and hydrocelectomy. Postoperative mortality was 1.7 % and 1.5 % in cases done by NPCs and physicians respectively. There was no significant difference in outcomes after procedures performed by NPCs compared with physicians.ConclusionsSurgical output is low and the workforce is limited in Tanzania. NPCs performed the majority of major surgical procedures during the study period. Outcomes after nonobstetric major surgical procedures done by NPCs and physicians were similar. Task‐shifting of surgical care to nonphysicians may be a safe and sustainable way to address the global surgical workforce crisis.
Several distinct wet periods since 420 ka in the Namib Desert inferred from U-series dates of speleothems
Authors: Geyh Mebus A. , Heine Klaus 
Published: January 2014

AbstractThe scarcity of numerical dates of the arid areas in southern Africa is a challenge for reconstructing paleoclimate. This paper presents a chronological reconstruction in the central part of the Namib Desert, Namibia, for the last 420,000 yr. It is based on 230Th/U dates (TIMS) from a large stalagmite and a thick flowstone layer in a small cave located in the hyper-arid central Namib Desert. The results provide for the first time evidence of three or possibly four succeeding wet periods of decreasing intensity since 420 ka through which speleothem deposited at approximately 420–385 ka, 230–207 ka and 120–117 ka following the 100-ka Milankovitch cycle. Speleothem growth was not recorded for the Holocene. These wet periods interrupted the predominantly dry climate of the Namib Desert and coincided with wet phases in deserts of the northern hemisphere in the Murzuq Basin, Sahara, the Negev, Israel, the Nafud Desert, Saudi Arabia, and the arid northern Oman, Arabian Peninsula.
Three new species ofGraphis(Ascomycota:Ostropales:Graphidaceae) from Mexico, with updates to taxonomic key entries for 41 species described between 2009 and 2013
Authors: BARCENAS PEÑA Alejandrina , LÜCKING Robert , MIRANDA-GONZÁLEZ Ricardo , HERRERA-CAMPOS María de los Angeles 
Published: January 2014

AbstractThree species ofGraphis(Graphidaceae) are described from Mexico from two research stations of the Universidad Nacional Autónoma de México (UNAM): Chamela Biological Station in the Cuixmala-Chamela Biosphere Reserve, Jalisco, and Los Tuxtlas Tropical Biological Station in the Los Tuxtlas Biosphere Reserve, Veracruz. The new speciesGraphis bungartziiBarcenas-Peña, Lücking, Herrera-Campos & R. Miranda is characterized by erumpent lirellae with a lateral thalline margin, striate labia and laterally carbonized exciple, transversely septate ascospores, and norstictic and connorstictic acids.Graphis chamelensisBarcenas-Peña & Lücking has prominent lirellae with a basal to lateral thalline margin, entire labia and completely carbonized exciple, transversely septate ascospores, and norstictic acid. Finally,Graphis rosae-emiliaeBarcenas-Peña & Lücking is characterized by erumpent lirellae with lateral thalline margin, striate labia and completely carbonized exciple, transversely septate ascospores, and no substances detected by TLC. We present updates to the world key toGraphisfor 41 newly described or reinstated species since the world key was published in 2009. The following new combination is proposed:Pallidogramme parvicarpum(B. O. Sharma & Khadilkar) Lücking comb. nov., based onGraphis parvicarpaB. O. Sharma & Khadilkar.