bluuebunny/crossref_metadata_2025_split huggingface dataset:
In vitro optimization of 2′-OMe-4′-thioribonucleoside–modified anti-microRNA oligonucleotides and its targeting delivery to mouse liver using a liposomal nanoparticle
Authors: Takahashi Mayumi , Yamada Naoki , Hatakeyama Hiroto , Murata Manami , Sato Yusuke , Minakawa Noriaki , Harashima Hideyoshi , Matsuda Akira 
Published: September 2013

Abstract
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. Previous studies, which characterized miRNA function, revealed their involvement in fundamental biological processes. Importantly, miRNA expression is deregulated in many human diseases. Specific inhibition of miRNAs using chemically modified anti-miRNA oligonucleotides (AMOs) can be a potential therapeutic strategy for diseases in which a specific miRNA is overexpressed. 2′-O-Methyl (2′-OMe)-4′-thioRNA is a hybrid type of chemically modified oligonucleotide, exhibiting high binding affinity to complementary RNAs and high resistance to nuclease degradation. Here, we evaluate 2′-OMe-4′-thioribonucleosides for chemical modification on AMOs. Optimization of the modification pattern using a variety of chemically modified AMOs that are perfectly complementary to mature miR-21 revealed that the uniformly 2′-OMe-4′-thioribonucleoside–modified AMO was most potent. Further investigation showed that phosphorothioate modification contributed to long-term miR-122 inhibition by the 2′-OMe-4′-thioribonucleoside–modified AMO. Moreover, systemically administrated AMOs to mouse using a liposomal delivery system, YSK05-MEND, showed delivery to the liver and efficient inhibition of miR-122 activity at a low dose in vivo.
Innovation in construction – before the curtain goes up
Authors: Davidson Colin 
Published: September 2013

Purpose
– This paper aims to present an overview of innovation in the construction sector, its forms, its inherent pitfalls and difficulties, and some underlying reasons for them. The familiar distinction between technical and organisational innovation is inapplicable in the fragmented construction industry.

Design/methodology/approach
– This paper is based on systematic observation, accompanying many years' hands-on experience.

Findings
– The processes of innovation in construction require that the innovator (possibly starting from a narrow idea or opportunity) broaden his/her view to take into account the impacts of the intended innovation on the priorities of other stakeholders, in an iterative process. In other words, orchestrated organisational changes must accompany – if not precede – technical innovation.

Research limitations/implications
– This paper specifically describes the processes and constraints of innovation in the context of the construction sector.

Practical implications
– Failure to take into account the dual obligation to innovate simultaneously on the organisational and technical fronts will lead to yet one more failed attempt. Such a failure represents a waste of time and effort, and a missed opportunity to contribute to improved construction.

Originality/value
– This paper is based on a uniquely broad experience-based view of innovation, covering a period of more than five decades; this feedback from experience can help innovators directly and provide evidence for subsequent research.
Conflicting values in reflection on professional practice
Authors: Siebert Sabina , Costley Carol 
Published: September 2013

Purpose
– The purpose of this paper is to examine the use of reflection as a tool of enquiry within the context of higher education work-based learning. The aim of the study is to investigate how reflection on professional practice brings about a review of the values underpinning that practice.

Design/methodology/approach
– The data were collected from a group of undergraduate students undertaking their studies by work-based learning in the area of management in a Scottish University. An open-ended questionnaire was designed to learn about the participants’ views on their perceived freedom to reflect on their workplace practice in the university, their ability to challenge the organizational values and established practices in the workplace, and on their relationship with the workplace mentor.

Findings
– Students on work-based learning programmes are subjected to demands from at least three directions: first, their own expectations, in terms of both what they want to achieve by way of their own development, second, the needs of their organization; and third, expectations of the university in ensuring that the work produced meets the standard for an academic award. These interests can sometimes coincide, but they can also conflict, and such a conflict can reveal tensions that run deeper into the culture of the organization.

Research limitations/implications
– This study is based on a relatively small sample of learners in one university, hence the findings are of preliminary nature. Despite the small sample size, the conclusions are indicative of a potential problem in the design of work-based learning, and a larger cross-institutional study would allow the validity of these results to be verified.

Practical implications
– The findings emerging from this study have implications for the facilitators of work-based learning in higher education. Although university work-based learning programmes differ significantly from corporate learning and development efforts, this paper suggests that work-based learning providers should co-operate more closely with the learners’ employing organizations towards creating an environment for learning at work. More co-operation between the university and the employer might be more beneficial for all stakeholders.

Originality/value
– The literature on work-based learning focuses in the main on the use of reflection as a tool of enquiry into workplace practice. Drawing on the study of contemporary work organizations, this paper explores the tensions arising from reflection on the learners’ practice, and possible conflict of values that reflection exposes.
The impact of ethics programmes and ethical culture on misconduct in public service organizations
Authors: Park Heungsik , Blenkinsopp John 
Published: September 2013

Purpose
– This paper aims to examine the relationship between ethics programmes and ethical culture, and their impact on misconduct.

Design/methodology/approach
– A theoretical model which posits ethical culture to be a mediating variable in the relationship between ethics programmes and misconduct was tested using data from a national ethics survey of Korean public service organizations.

Findings
– The data indicates the relationship between ethics programmes and misconduct is fully mediated by ethical culture. Only two of the six elements of an ethics programme had a significant effect on misconduct before ethical culture was controlled for, and when ethical culture was controlled for, none of the elements had a significant impact on misconduct. The ethics programme did however appear to strengthen ethical culture, suggesting such programmes make an important contribution to reducing unethical behaviour in organizations.

Research limitations/implications
– Future research should examine the interaction of ethics programmes and ethical culture using longitudinal research designs, to obtain a better understanding of how programmes serve to strengthen ethical culture.

Practical implications
– The findings provide insights into the role of ethics programmes in improving ethical behaviour, suggesting resources should be deployed to those aspects of these programmes which serve to strengthen ethical culture.

Originality/value
– The paper provides clarification of the relationship between ethics programmes, ethical culture and misconduct, an important finding given the significant resources deployed by public service organizations to initiatives aimed at improving ethical behaviour.
Assembling the Dubai Government Excellence Program
Authors: Ahrens Thomas 
Published: September 2013

Purpose– This paper seeks to outline the various elements of a public sector excellence awards programme, the Dubai Government Excellence Programme (DGEP), a unit reporting directly to the cabinet of the Dubai Government. It identifies how the programme seeks to overcome latent contradictions.Design/methodology/approach– The approach relied on interviewing within DGEP, document analysis, conversations with public sector managers in Dubai and Abu Dhabi, and more general observations of the nature of government in the UAE and especially Dubai. The notion of hybrids in governance is used to unpack the various components of the DGEP and their roles in its overall functioning paying particular attention to the monarchical context of Dubai and the United Arab Emirates.Findings– The study found that the monarchical context of public sector management in Dubai acts as a strong influence to counteract the frequently observed inertia of public administration with regards to quality management initiatives. It traces how changing political priorities have been reflected in a changing portfolio of excellence award categories.Originality/value– The paper describes an unusual case of an integrated excellence management approach to a whole government. It identifies monarchical context as an aid to pursuing a modern management approach, speculating that this might be a special case of a more general condition that might aid innovation in public sector contexts. The paper also suggests the usefulness of the notion of hybrids for the public sector governance literature.
Outsourcing and concession models as door opener for public-private partnerships in the European health sector?
Authors: Dieter Gerstlberger Wolfgang , Schneider Karsten 
Published: September 2013

Purpose
– The purpose of this paper is to reduce the research gap in private sector participation in the Danish and German health systems, where empirical evidence is still very scarce compared with the impressive accumulation of similar literature in Anglo-Saxon countries.

Design/methodology/approach
– Based on the findings of two case studies – one Danish and the other, a German hospital – the paper assesses the future potential of different private sector participation strategies in health care.

Findings
– The assessment is that low-level private sector participation approaches such as outsourcing and concession models remain limited and specialised financing instruments for health care in Denmark and Germany due to legal restrictions and lesser importance being placed on operational financial savings and improved management than on achieving strategic goals. Furthermore, existing approaches do not necessarily prepare the ground for public-private partnerships.

Research limitations/implications
– To date, longitudinal studies of private sector participation in health care are almost non-existent for continental Europe, yet critical for the assessment of the outcomes of long-term projects of ten to 40 years' duration. In addition, there is still a need for more international comparisons, especially for studies comparing more than two countries.

Originality/value
– Case studies about private sector participation in health care with transnational European or international comparisons are very scarce. The paper, which compares two cases of a Danish and a German hospital, is therefore a contribution to reducing a relevant research gap. To date, private sector participation in the German health system, in particular, has rarely been discussed in international journal publications.
The relationship between transformational leadership and cultural intelligence
Authors: K. Keung Emerson , J. Rockinson-Szapkiw Amanda 
Published: September 2013

Purpose
– The purpose of this study is to examine if there is a relationship between the factors of cultural intelligence and transformational leadership in international school leaders.

Design/methodology/approach
– This correlational research study examined 193 international school leaders, who participated in a survey that included the Cultural Intelligence Scale and the Multifactor Leadership Questionnaire 5X. A standard multiple regression analysis was used to determine if the factors of cultural intelligence predict transformational leadership. The individual contribution of each factor to the model was examined.

Findings
– The results indicate that there is a significant positive relationship between cultural intelligence and transformational leadership in international school leaders. Leaders who have a higher level of cultural intelligence exhibit a higher level of transformational leadership style, which suggests that individuals with high-cultural intelligence are able to lead and to manage more effectively in multicultural environments. Behavioral cultural intelligence and cognitive cultural intelligence were found to be the best predictors of transformational leadership.

Practical implication
– The results provide insight into the selection, training, and professional development of international school leaders. Practical implications are provided for integrating cultural intelligence into higher education curriculum.

Originality/value
– This paper makes a unique contribution to the nomological network of cultural intelligence by identifying which factors of cultural intelligence best predict transformational leadership in international school leaders, a population to which this model had not been previously applied.
In the name of honor: Swedish school leaders’ experiences of honor-related dilemmas
Authors: Norberg Katarina , Törnsén Monika 
Published: September 2013

Purpose
– The purpose of this paper is to examine honor-related dilemmas that principals encounter in daily practice. Such dilemmas illustrate how special demands from parents can collide with the school's democratic mission.

Design/methodology/approach
–In total, 53 principals who participated in an in-service program, which aimed to enhance consciousness and knowledge concerning honor-related issues, were asked to describe their experiences of honor-related dilemmas. The paper uses the understanding of the honor culture as an analytic probe in studying and understanding the dilemmas and how these collide with the school's inner work in accordance with democratic values.

Findings
– The major findings illustrate that the participating principals have to deal with honor-related issues in their daily practice. The dilemmas include parents’ demands for restrictions affecting girls, young women, boys, and young men from preschool up to adult education. These restrictions limit their right to participate in all school subjects and activities and to live a life free of oppression.

Practical implications
– The paper reveals the importance of enhanced consciousness and knowledge concerning honor-related issues. Principals must have the ability to identify and recognize at-risk students and organize the necessary support for those students without stigma and exclusion. How the school's structure and culture support intercultural practice and inclusion is important to avoid a contribution to marginalization and a rejection of the school's value base.

Originality/value
– A number of research studies have been done regarding culture clashes in the multicultural school context. This paper identifies dilemmas that can be related to the honor culture and how these are expressed in the principal's office.
Perspectives of school leaders on the administrative internship
Authors: A. Thessin Rebecca , Clayton Jennifer 
Published: September 2013

Purpose– The purpose of this study was to identify how current K-12 district and school leaders who are alumni of an educational administration program describe how they acquired the essential skills and experiences needed to be effective in the leadership positions.Design/methodology/approach– For this qualitative study, the authors interviewed program alumni of one university leadership preparation program regarding the experiences and training they identified as having prepared them with the necessary skills, knowledge, and attitudes to be successful in their positions, as well as which components of their administrative internship experiences, if any, they identified as having most prepared them for their positions.Findings– School and district administrators indicated they acquired the knowledge, skills, and attitudes necessary to become successful leaders through specific preparation experiences and opportunities. Key experiences cited by alumni included gaining some leadership responsibilities while they were teachers and further opportunities to lead in the administrative internship; engaging in practical, hands-on assignments in their graduate degree program courses; learning from other administrators with unique areas of work responsibilities, as well as from other schools and districts; and receiving guidance from a dedicated mentor.Originality/value– The findings from this study contribute to research in the area of administrator preparation by guiding preparation programs in prioritizing the types of training and practicum experiences that aspiring K-12 educational leaders receive as a component of their preparation programs.
Exploring the link between the humanitarian logistician and training needs
Authors: Marie Allen Ann , Kovács Gyöngyi , Masini Andrea , Vaillancourt Alain , Van Wassenhove Luk 
Published: September 2013

Purpose
– The aim of this paper is to evaluate job profiles in humanitarian logistics, and assess current task priorities in light of further training and educational needs.

Design/methodology/approach
– The paper presents findings from a survey among humanitarian logistics practitioners and compares these to other studies in this area. It uses econometric models to evaluate the impact of managerial responsibilities in training needs, usage of time and previous training.

Findings
– The results show that the skills required in humanitarian logistics seem to follow the T-shaped skills model from Mangan and Christopher when looking at training wanted and time usage.

Research limitations/implications
– Survey respondents being members of the Humanitarian Logistics Association (HLA) may be more interested in developing the humanitarian logistics profession than other populations.

Originality/value
– This paper offers an insight in the specific skill requirements of humanitarian logisticians from members of the HLA and allows to understand which type of skills are linked to managerial responsibilities. The paper also establishes a link between logistics skill models and career progressions overall.
A comparison between select open source and proprietary integrated library systems
Authors: Pruett Joseph , Choi Namjoo 
Published: September 2013

Purpose– As libraries face budget cuts, open source integrated library systems are an attractive alternative to proprietary choices. Even though open source software is free to acquire, administrators must consider factors other than initial purchase price. This study aims to provide direction and context for libraries considering migration to an open source integrated library system.Design/methodology/approach– The comparison is qualitative and uses case studies, license agreements and copyright law, and user manuals and brochures. These comparisons divide into four areas: functions, adoption and technical support, usability, and economics.Findings– Major functions that libraries need in an integrated library system are available for open source software. There are no significant differences in usability between open source and proprietary integrated library systems. Internal IT provides a significant role in open source adoption. The relatively new type of open source software licensing may cause confusion for libraries and software developers.Originality/value– This study considers initial migrations to open source integrated library systems as a key component in overall software adoption. The study qualitatively examines the migration process comparing extant case studies. In addition, the examination of licensing agreements and copyright as well as a comparative review of essential functions are provided.
Library mobile applications in university libraries
Authors: Chang Chiao-Chen 
Published: September 2013

Purpose
– This research aims to integrate the unified theory of acceptance and usage of technology (UTAUT) with task technology fit to explain users' behavioral intention of using library mobile applications in university libraries.

Design/methodology/approach
– By integrating the unified theory of acceptance and usage of technology (UTAUT) and the moderator of task-technology fit, this research proposes a library mobile applications usage intention model. The study data come from a convenience sample of 363 undergraduate and graduate students. A structural equation modelling (SEM) technique was conducted to identify causal relationships.

Findings
– Results showed that the UTAUT model fits the data well. The empirical data reveal that performance expectancy, effort expectancy, social influence, and facilitating conditions determine users' behavioral intention of using library mobile applications. As a determinant in the UTAUT model, the moderating effect of task-technology fit is also significant. Moreover, individuals with different levels of task-technology fit will strengthen or weaken the relationships of determinants in the intention to use library mobile applications in university libraries.

Research limitations/implications
– This study addresses self-reported behavioral intentions as part of the survey; as a result, the data may have introduced inaccuracies. The implications of the proposed library mobile applications success model are discussed.

Practical implications
– University librarians should reinforce the efficiency of library mobile applications to influence users' willingness to use such applications.

Originality/value
– This study combines both the constructs of the UTAUT model and task-technology fit to consider intentions to use library mobile applications in university libraries.
Factors affecting the performance of mobile office outsourcing
Authors: Lee Jongtae , Park Myeong-Cheol , Moon Junghoon 
Published: September 2013

Purpose– A mobile office can be defined as software and hardware that support business work and that are accessible via smartphones. Organizations are adopting or trying to adopt the mobile office as their communication and business tool, in order to support or to change their current work environments. The purpose of this paper is to focus on the impact of outsourcing strategy on mobile office performance based on the FORT model and the MoBiS-Q to measure the performance of the outsourced mobile office.Design/methodology/approach– This study focuses on the impact of outsourcing strategy on mobile office performance based on the FORT model and the MoBiS-Q to measure the performance of the outsourced mobile office.Findings– In the results, the perceived usability and the perceived impact of the mobile office on the productivity can be higher with the Alliance outsourcing relationship type. The outsourcing of the mobile office would follow the similar process of other IT outsourcing strategies. But the device fittingness was far from the expectation.Research limitations/implications– Firms/organizations should consider a more concrete step-by-step approach to strategic outsourcing relationships with the high-skilled expert groups and that the device fittingness may not be a proper factor to measure the performance of the outsourced mobile office.Practical implications– IT managers who plan or now try to adopt the mobile office into their organizations should focus on developing proper applications and software; however, they do not need to care about device or H/W issues, including employees ' skills at using the devices or the device fittingness for the planned mobile office.Originality/value– This study is one of the first academic studies to analyze the impact of outsourcing strategy of the mobile office on organization performance.