bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wnt/β-catenin pathway as a potential target for Parkinson’s disease: a cohort study of romosozumab using routinely collected health data in Japan
Authors: Inokuchi Shoichiro , Shimamoto Koji 
Published: July 2024

IntroductionRomosozumab is a monoclonal antibody approved for osteoporosis which targets sclerostin, an endogenous inhibitor of Wnt/β-catenin pathway. Given the essential roles of the Wnt/β-catenin pathway in various tissues, we hypothesized romosozumab treatment may influence other conditions.MethodsThis cohort study included patients prescribed romosozumab or parathyroid receptor (PTHR) agonists after 1 January 2019, using a Japanese electronic medical record database. The outcomes of interest included autoimmune disease, interstitial pneumonia, cardiovascular outcome, Alzheimer’s disease, Parkinson’s disease (PD), serious infections, and malignancies. A stabilized inverse probability-weighted Cox proportional hazard model was used to estimate the hazard ratios. Age- and gender-based subgroup analyses were conducted. Exploratory outcomes based on three-digit International Classification of Diseases 10th Revision-based were also examined.ResultsIn total, 2,673 patients treated with romosozumab and 5,980 treated with PTHR agonists were identified, respectively. While most outcomes of interest showed no association with romosozumab, the risk of PD decreased with romosozumab (hazard ratio [95% confidence interval], 0.37 [0.14–0.94]) compared with PTHR agonist. Regarding the cardiovascular outcome, no notable association was identified overall; however, gender-based subgroup analysis suggested that male sex may be a potential risk factor with romosozumab treatment. Only 16 of 903 exploratory outcomes were potentially influenced by romosozumab.ConclusionRomosozumab lowered the risk of PD development compared with PTHR agonist. The study also highlights the utility of routinely collected health data for drug repositioning. While further validation is warranted, the findings suggest that the Wnt-β-catenin pathway holds promise as a therapeutic target for PD.
Exploring the effect of environmental sensitivity on emotional fluctuations among adolescents during the COVID-19 pandemic: a three-wave longitudinal study
Authors: Dragone Mirella , Colella Alessandra , Esposito Concetta , Bacchini Dario 
Published: July 2024

IntroductionThe COVID-19 pandemic significantly impacted the emotional well-being of adolescents worldwide. Some studies suggested that individuals with high Environmental Sensitivity may have been more likely to experience poor psychological adjustment during the pandemic than those with lower sensitivity. However, there is still limited research on how emotional responses varied across different stages of the pandemic and whether Environmental Sensitivity increased adolescents’ vulnerability to the psychological impact of prolonged pandemic restrictions.MethodsTo address this gap, this study used a three-year longitudinal design (2020–2022) with a sample of 453 adolescents. They completed an online survey measuring their positive and negative emotions throughout the pandemic period, with Environmental Sensitivity considered a time-invariant covariate.ResultsThe results revealed that all participants, regardless of their level of Environmental Sensitivity, experienced a decrease in positive emotionality between the first and second years. However, this trend reversed, showing an increase between the second and third years. Regarding negative emotions, highly sensitive adolescents experienced a significant linear increase over time. In contrast, low-and medium-sensitive adolescents exhibited a quadratic trend, with a notable increase in negative emotions between the first and second years, followed by a slight decrease between the second and third years.DiscussionThese findings provide further evidence of the negative impact of the pandemic on adolescents’ emotional well-being. They also support the notion that Environmental Sensitivity is associated with individuals’ ability to respond and adjust to adverse life events, with significant implications for future research and practice.
Co-teaching in higher education: implications for teaching, learning, engagement, and satisfaction
Authors: Zach Sima , Avugos Simcha 
Published: July 2024

IntroductionThis study examined the impact of co-teaching on students and lecturers, assessing its benefits and drawbacks, and suggesting ways to enhance collaborative learning.MethodsFifty undergraduate student teachers participated in two sports sciences seminar courses jointly taught by two lecturers. Data was collected via student reflections; course evaluation feedback; word clouds; and teacher reflections. Thematic analysis was used for qualitative data.ResultsThe findings indicate that the short intensive seminar course resulted in three parallel processes: emotional, students transitioning from negative feelings of chaos, frustration, and a sense of incompetence to positive feelings of satisfaction and sense of accomplishment; social, students learning to listen, request assistance, support, encourage, and collaborate; and cognitive, students learning to ask fruitful questions, plan experiments, summarize, and present. Nevertheless, the time and effort demands involved in the planning and management of such courses may constitute a significant barrier to the future implementation of this teaching method. In terms of course outcomes, no indications of higher quality were seen compared to traditional instruction.DiscussionDrawing on the symbolic interactionism theory, the study advocates for preparing students for inclusive and collaborative learning environments to improve academic engagement and success.
New Interval-Valued Soft Separation Axioms
Authors: Baek Jong Il , Al-shami Tareq M. , Jafari Saeid , Cheong Minseok , Hur Kul 
Published: July 2024

Our research’s main aim is to study two viewpoints: First, we define partial interval-valued soft T i(j)-spaces (i = 0, 1, 2, 3, 4; j = i, ii), study some of their properties and some of relationships among them, and give some examples. Second, we introduce the notions of partial total interval-valued soft T j(i)-spaces (i = 0, 1, 2, 3, 4; j = i, ii) and discuss some of their properties. We present some relationships among them and give some examples.
Phosphorus-Solubilizing Bacteria Enhance Cadmium Immobilization and Gene Expression in Wheat Roots to Reduce Cadmium Uptake
Authors: Kan Delong , Tian Minyu , Ruan Ying , Han Hui 
Published: July 2024

The application of phosphorus-solubilizing bacteria is an effective method for increasing the available phosphorus content and inhibiting wheat uptake of heavy metals. However, further research is needed on the mechanism by which phosphorus-solubilizing bacteria inhibit cadmium (Cd) uptake in wheat roots and its impact on the expression of root-related genes. Here, the effects of strain Klebsiella aerogenes M2 on Cd absorption in wheat and the expression of root-related Cd detoxification and immobilization genes were determined. Compared with the control, strain M2 reduced (64.1–64.6%) Cd uptake by wheat roots. Cd fluorescence staining revealed that strain M2 blocked the entry of exogenous Cd into the root interior and enhanced the immobilization of Cd by cell walls. Forty-seven genes related to Cd detoxification, including genes encoding peroxidase, chalcone synthase, and naringenin 3-dioxygenase, were upregulated in the Cd+M2 treatment. Strain M2 enhanced the Cd resistance and detoxification activity of wheat roots through the regulation of flavonoid biosynthesis and antioxidant enzyme activity. Moreover, strain M2 regulated the expression of genes related to phenylalanine metabolism and the MAPK signaling pathway to enhance Cd immobilization in roots. These results provide a theoretical basis for the use of phosphorus-solubilizing bacteria to remediate Cd-contaminated fields and reduce Cd uptake in wheat.
Approaching Environmental Sustainability through Energy Optimization in Polyisoprene Production
Authors: Mihelić-Bogdanić Alka , Špelić Ivana 
Published: July 2024

The global energy crisis, forced by fossil fuel shortages and supply chain disruption, stimulates EU policymakers to find alternative energy replacement. Modifying the present polyisoprene footwear production plant into a hybrid system by combining different energy sources raises energy efficiency. The proposed hybrid system incorporates classical and solar-based technology, resulting in energy optimization by utilizing waste heat recovery. By installing an economizer for feeding water preheating using flue gas recovery, it results in the volume of the flue gases lowering from vFGP=1.7969 m3FG/kgP to vFGECOP=1.597 m3FG/kgP, or by 11.13%, while the flue gases’ temperature is lowered from 204 °C (477.15 K) to 50.99 °C (324.14 K). Further improvement in combining feed water and air preheating results in natural gas savings of 12.05%, while the flue gases’ exhaust temperature is decreased to 30.44 °C (303.59 K). The third option, using condensate heat recovery and feeding water preheating using flue gases, showed natural gas savings as much as 17.41% and exhaust flue gases cooling to 112.49 °C (385.64 K). The combination of condensate heat recovery, combustion air and feed water preheating results in the volume of the flue gases being lowered by 20.42% and natural gas savings by 20.24%, while the flue gases’ temperature is reduced to 45.11 °C (318.26 K). The proposed solar application in polyisoprene production predicts the hybrid system showing fuel savings ranging from 77.96% to 87.08% in comparison to the basic process. The greatest fuel savings of 87.08% is shown in a solarized polyisoprene footwear production plant with combustion air and feed water preheating combined with the condensate return system. Integrating the solar heat into the regular industrial process of polyisoprene production showed great potential and showed environmental sustainability through energy optimization in polyisoprene production.
The Δ Anion Gap/Δ Bicarbonate Ratio in Lactic Acidosis: Time for a New Baseline?
Authors: Lu Deborah , Song Hubert , Amy Liu In-Lu , Shi Jiaxiao , Treger Richard M. 
Published: July 2024

Key Points

The mean delta anion gap (ΔAG)/delta bicarbonate (ΔHCO3) calculated using an albumin-corrected anion gap and each patient's individual baseline AG and serum HCO3 was 1.20.The ΔAG/ΔHCO3 using mean normal AG and serum HCO3 was 1.6–1.8; use of mean normal values can result in misdiagnosis of complex acid-base disorders.The elevated ΔAG/ΔHCO3 is likely due to unmeasured anions.

Background
The ratio of delta anion gap and delta bicarbonate (ΔAG/ΔHCO3) is used to detect coexisting acid-base disorders in patients with high anion gap metabolic acidosis. The ΔAG/ΔHCO3 ratio of 1.6–1.8:1 in lactic acidosis is derived from limited data using mean normal values for anion gap (AG) and serum HCO3. The objective of this study was to be the first to examine the ΔAG/ΔHCO3 using each patient's individual baseline AG and serum HCO3.

Methods
This was a retrospective cohort study of adult intensive care unit (ICU) patients with sepsis. Laboratory data from simultaneously drawn chemistry panel, including anion gap and serum lactate on admission to the ICU, were obtained. Baseline AG, HCO3, and albumin measurements were obtained 1–24 months before ICU admission. The ΔAG/ΔHCO3 was calculated using an albumin-corrected anion gap and each patient's individual baseline AG and serum HCO3.

Results
Three hundred forty-four patients were included. One hundred twenty-eight patients had normal serum lactate levels (≤1.9 mmol/L), and 216 patients had elevated serum lactate levels (>1.9 mmol/L). ΔAG/ΔHCO3 was calculated for the 216 patients who had elevated serum lactate levels (>1.9 mmol/L). The mean ΔAG/ΔHCO3 for all patients with elevated serum lactate levels was 1.20 (SD 1.50).

Conclusions
The mean ΔAG/ΔHCO3 calculated using an albumin-corrected anion gap and each patient's individual baseline AG and serum HCO3 was 1.20. The ΔAG/ΔHCO3 reported in prior literature that used mean normal AG and serum HCO3 was 1.6–1.8, highlighting that use of mean normal values affects the calculation of the ΔAG/ΔHCO3 and subsequent conclusions about underlying pathophysiology. The use of these mean normal values can result in misdiagnosis of complex acid-base disorders and inappropriate treatment. Our analysis indicates that the elevated ΔAG/ΔHCO3 is likely due to unmeasured anions contributing to an elevation in AG.
Innovative economy in the structure of modern national economy
Authors: Челпанова М.М. 
Published: July 2024

В статье рассмотрены концептуальные основы инновационной экономики. Опреде лены базовые принципы, признаки инновационной экономики, указаны ее особенности, представлена классификация инноваций. Сделан вывод о перспективах стратегического развития Российской Феде рации.
The article discusses the conceptual foundations of an innovative economy. The basic principles, signs of an innovative economy are identified, its features are indicated, the classification of innovations is pre sented. A conclusion is drawn on the prospects for the strategic development of the Russian Federation.
Economic prospects for the development of the fuel and energy complex Iran under sanctions
Authors: Белодедов М.И. , Жизнин С.З. 
Published: July 2024

В статье представлены результаты исследования экономических перспектив раз вития ТЭК Ирана в условиях санкций. Дана общая характеристика Топливно-энергетического комплек са Ирана. Проведен анализ перспектив развития и рисков ТЭК Исламской Республики, в том числе по отдельным энергетическим отраслям (ядерная энергетика, нефтегазовый комплекс, тепловая энер гетика, альтернативная энергетика). Отмечено влияние санкций на ТЭК Ирана. Результаты иссле дования могут быть использованы при подготовке аналитических справок и отчетов в области миро вой экономики, энергетической дипломатии, а также межправительственного экономического со трудничества.
The article presents the results of a study of the economic prospects for the development of Iran’s fuel and energy complex under sanctions. The general characteristic of the fuel and energy complex of Iran is given. The analysis of the development prospects and risks of the fuel and energy complex of the Islamic Re public, including in certain energy sectors (nuclear energy, oil and gas complex, thermal energy, alternative ener gy), is carried out. The effect of sanctions on Iran’s fuel and energy complex is noted. The results of the study canbe used in the preparation of analytical reports and reports in the field of the world economy, energy diplomacy,as well as intergovernmental economic cooperation.
New trends in the field of labor and employment in the digital environment
Authors: Давыдова Т.Е. , Авдеева Е.А. , Воротынцева А.В. 
Published: July 2024

Рынок труда рассматривается нами с позиции целей его развития в современной цифровой экономике. Проведен анализ научной литературы с учетом основных направлений исследо вания рынка труда. В их числе выделены: формирование совместной экономики, создание цифровых платформ и прозрачной информационной среды, мобильность рынка труда, повышение квалификации и переподготовка работников, развитие системы образования, значимость человеческого потенциа ла. Изучен опыт зарубежных стран, исследовано состояние национального рынка труда. Исследованы структурные особенности занятости, в том числе, отраслевые. Представлены результаты иссле дования перспектив развития системы образования и повышения квалификации работников в условиях цифровизации национальной экономики. Обобщен опыт университетов в области реализации про грамм государственно-частного партнерства, в том числе, Воронежского государственного техни ческого университета. Определены направления и риски развития рынка труда России, предложены меры по его стабилизации.
We consider the labor market from the perspective of its development goals in the modern digital economy. The analysis of scientific literature is carried out taking into account the main directions of research on labor and employment. Among them are highlighted: the creation of digital platforms and an accessible, transpar ent information environment, increased labor market mobility, advanced training, training and retraining of work ers, the development of a higher education system, the importance of human potential. The experience of foreign countries was studied, the state of the national labor market was investigated. The structural features of employ ment, including industry ones, are investigated. The results of a study of the prospects for the development of the higher education system and advanced training of workers in the digitalization of the national economy are pre sented. The experience of universities in the implementation of public-private partnership programs, including the Voronezh State Technical University, is summarized. The directions and risks of the development of the Russian labor market are identified, measures are proposed for its stabilization.
Значение налога на прибыль организаций в формировании бюджетных доходов страны
Authors: Козаева О.Т. , Козаева Ф.М. 
Published: July 2024

Статья посвящена исследованию роли и значения налога на прибыль предприятий в доходах бюджета, проведению анализа динамики поступлений налога на прибыль организаций. Рас сматривается значимость налога на прибыль организаций в общей совокупности бюджетных поступ лений РФ. В качестве объекта для анализа в исследовании выбрана Республика Северная Осетия Алания. При исследовании применен общий прием сравнительного анализа, широко используемый в научных экономических исследованиях.
The article is devoted to the study of the role and importance of corporate income tax in budget revenues, analysis of the dynamics of corporate income tax revenues. The significance of the corporate income tax in the total aggregate of budget revenues of the Russian Federation is considered. The Republic of North Ossetia-Alania was selected as the object for analysis in the study. The study used the general method of comparative analysis, widely used in scientific economic research.
Public-private partnership in the Russian Federation: legislative framework
Authors: Мусаева З.С. , Мусаев М.С. 
Published: July 2024

Данная статья посвящена исследованию вопроса государственно-частного парт нерства. В статье рассмотрены определение государственно-частного партнерства, его отличие от других мер поддержки предприятий бизнеса государством, принципы функционирования государ ственно-частного партнерства, его формы, наиболее часто встречающиеся в российской экономике. А также приведены данные по успешному сотрудничеству государства и частного сектора на приме рах осуществленных проектов.
This article is devoted to the study of public-private partnership. The article discusses the definition of public-private partnership, its difference from other measures to support business enterprises by the state, the principles of functioning of public-private partnerships, its forms that are most common in the Russian economy. And also provides data on successful cooperation between the state and the private sector on the examples of completed projects.
Specificity (features) of development of implementation of projects of road infrastructure using the mechanism of state-private partnership in the Russian Federation
Authors: Кырлан М.Г. , Валиев Ш.Д. 
Published: July 2024

В статье рассматривается специфика (особенности) развития реализации проек тов автодорожной инфраструктуры с применением механизма государственно-частного партнер ства в практике Российской Федерации. Авторы подчёркивают важную роль государственно-частного партнерства в привлечении инвестиций в транспортную инфраструктуру. Как важные механизмы реализации государственно-частного партнерства рассматриваются концессионные соглашения и контракт жизненного цикла.
The article discusses the specifics (features) of the development of road infrastructure projects using the mechanism of public-private partnership in the practice of the Russian Federation. The authors emphasize the important role of public-private partnerships in attracting investment in transport infrastructure. As important mechanisms for implementing public-private partnerships, concession agreements and a life cycle contract are considered.
Modernization of innovative development of the region with a view to sustainable development
Authors: Гусейнов А.Г. , Абдуллаева Д.А. 
Published: July 2024

В данной статье рассматривается инновационное развитие региона в рамках концепции устойчивого развития. Проанализирована сущность концепции устойчивого развития и ее составляющие. Рассмотрено содержание воспроизводственного потенциала региона и его инновационной составляющей. Сделан выводы о роли инновационного аспекта в парадигме устойчивого развития.
This article discusses the innovative development of the region in the framework of the concept of sustainable development. The essence of the concept of sustainable development and its components is analyzed. The content of the reproductive potential of the region and its innovative component is considered. Conclusions are drawn on the role of the innovative aspect in the paradigm of sustainable development.
The main directions of further development of the agricultural land market
Authors: Зайцева Я.В. 
Published: July 2024

В статье уточнено понятие земельного рынка. Дана характеристика первичного и вторичного рынков земли. Исходя из профессиональных, а не политико-популистских позиций предложен ряд действий для вывода рынка сельхозземель из ступора. Предлагается принять закон о рынке сельхозземель, который будет включать в себя ряд обязательных условий. Он чётко определит начало, порядок и процедуру купли-продажи земель сельскохозяйственного назначения. Это и будет являться основным условием для полноценного развития рынка земель сельскохозяйственного назначения.
The article clarifies the concept of the land market. The characteristic of the primary and secondary land markets is given. Proceeding from professional rather than political-populist positions, a number of actions have been proposed to withdraw the agricultural land market from a stupor. It is proposed to adopt a law on the agricultural land market, which will include a number of mandatory conditions. It will clearly determine the beginning, procedure and procedure for the sale of agricultural land. This will be the main condition for the full development of the agricultural land market.
Main directions of the mechanism for strengthening the tax potential of the region
Authors: Абдуллаева З.М. , Султанов Г.С. 
Published: July 2024

В статье рассмотрены основные направления механизма укрепления налогового потенциала региона. Изучены проблемы укрепления налогового потенциала региона. Раскрыты разные подходы понимания категории «налоговый потенциал». Описаны характеристики налогового потенциала региона. Схематично в статье представлен Механизм укрепления налогового потенциала региона. Рассмотрены направления увеличения налоговой базы по основным налогам. Изучены факторы, влияющие на формирование налогового потенциала. В завершении приведены приоритетные направления в реализации стратегического планирования развития налогового потенциала региона.
The article considers the main directions of the mechanism for strengthening the tax potential of the region. The problems of strengthening the tax potential of the region are studied. Different approaches to understanding the "tax potential" category are disclosed. The characteristics of the tax potential of the region are described. Schematically, the article presents the mechanism of strengthening the tax potential of the region. The directions of increasing the tax base for basic taxes are considered. The factors influencing the formation of tax potential are studied. The report provides priority directions in the implementation of strategic planning for the development of the tax potential of the region.