bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of proteins regulated by interleukin-4 in 3T3-L1 adipocytes
Authors: Shiau Ming-Yuh , Lu Hsu-Feng , Chang Yih-Hsin , Chiu Yen-Chih , Shih Yung-Luen 
Published: June 2015

AbstractObesity is closely associated with metabolic syndrome, type 2 diabetes mellitus (T2DM) and cardiovascular diseases. Our previous reports uncover the significant associations betweeninterleukin-4 (IL-4)/IL-4 receptorgenotypes and T2DM, as well asIL-4genotypes and high density lipoprotein-cholesterol. Theses observations suggest that IL-4 harbors the capacity to regulate lipid metabolism. The present study is aimed at further elucidating regulatory roles of IL-4 to lipid metabolism by identifying putative proteins in 3T3-L1 adipocytes which are differentially expressed under IL-4 treatment. Proteins in mature 3T3-L1 adipocytes with altered expression levels under IL-4 treatment were identified by proteomic strategy. Our results revealed that IL-4 up-regulated levels of ATP synthase δ chain, Cytochromecreductase, Pyrophsphatase and Vimentin, whereas, Alpha-enolase, Gelsolin, Vinculin and Valosin were down-regulated. These observations suggest that IL-4 promotes energy metabolism and inhibit lipid deposits in adipocytes by up-regulating proteins accelerating ATP synthesis. Our results suggest that IL-4 facilitates adipocytes metabolism to catabolism with a favorable condition for lipolysis. These catabolized lipids in adipocytes triggered by IL-4 might either be released into periphery or metabolized intracellularlly, and modulate systemic energy metabolism.
Assessing source rock distribution in Heather and Draupne Formations of the Norwegian North Sea: A workflow using organic geochemical, petrophysical, and seismic character
Authors: Badics Balazs , Avu Anthony , Mackie Sean 
Published: June 2015

The organic-rich upper Jurassic Draupne and Heather Formations are the main proven source rocks of the Norwegian North Sea. We have developed a workflow for the organic geochemical, petrophysical, and seismic characterization of the Draupne and Heather Formation source rocks in a [Formula: see text] study area in quadrant 25 in the Viking Graben in the Norwegian North Sea. We characterized the vertical and lateral organic richness variations using biostratigraphy, organic geochemical data, and petrophysical logs. The Draupne Formation is a rich (6.5 wt.% total organic carbon [TOC], 360 HI), oil-prone, immature to early oil mature source rock, representing a 25-m-thick condensed section, partly eroded over the Utsira high and thickening to 150–300 m toward the deep grabens. The underlying Heather Formation is also an oil-prone (4.4 wt.% TOC, 270 HI), 30- to 400-m-thick, more mature source rock. To map the TOC distribution using seismic, we performed detailed seismic interpretation and seismic attribute analysis following the petrophysical calibration of TOC with the [Formula: see text] ratio and P impedance on well data. Similar patterns of low-impedance high-TOC areas highlighted and mapped from the petrophysical studies at the Heather level were also observed on seismic relative acoustic impedance and amplitude maps over the study area. The poststack seismic data conditioning (structurally orientated noise reduction) improved the quality of the input megamerge seismic data and allowed the application of colored inversion, structural and fault imaging, as well as multiattribute combination and visualization techniques, which have been efficient in highlighting the distribution of high-TOC areas, structure and fault zones within the study area.
Randomized Phase III Trial of Paclitaxel Once Per Week Compared With Nanoparticle Albumin-Bound Nab-Paclitaxel Once Per Week or Ixabepilone With Bevacizumab As First-Line Chemotherapy for Locally Recurrent or Metastatic Breast Cancer: CALGB 40502/NCCTG N063H (Alliance)
Authors: Rugo Hope S. , Barry William T. , Moreno-Aspitia Alvaro , Lyss Alan P. , Cirrincione Constance , Leung Eleanor , Mayer Erica L. , Naughton Michael , Toppmeyer Deborah , Carey Lisa A. , Perez Edith A. , Hudis Clifford , Winer Eric P. 
Published: June 2015

PurposeWe compared nab-paclitaxel or ixabepilone once per week to paclitaxel with bevacizumab as first-line therapy for patients with advanced breast cancer (BC) to evaluate progression-free survival (PFS) for nab-paclitaxel or ixabepilone versus paclitaxel.Patients and MethodsEligible patients were age ≥ 18 years with chemotherapy-naive advanced BC. Patients were randomly assigned to bevacizumab with paclitaxel 90 mg/m2(arm A), nab-paclitaxel 150 mg/m2(arm B), or ixabepilone 16 mg/m2(arm C), once per week for 3 of 4 weeks. Planned enrollment was 900 patients, which would give 88% power to detect a hazard ratio of 0.73.ResultsIn all, 799 patients were enrolled, and 783 received treatment (97% received bevacizumab). Arm C was closed for futility at the first interim analysis (n = 241), and arm A (n = 267) and arm B (n = 275) were closed for futility at the second interim analysis. Median PFS for paclitaxel was 11 months, ixabepilone was inferior to paclitaxel (PFS, 7.4 months; hazard ratio, 1.59; 95% CI, 1.31 to 1.93; P < .001), and nab-paclitaxel was not superior to paclitaxel (PFS, 9.3 months; hazard ratio, 1.20; 95% CI, 1.00 to 1.45; P = .054). Results were concordant with overall survival; time to treatment failure was significantly shorter in both experimental arms v paclitaxel. Hematologic and nonhematologic toxicity, including peripheral neuropathy, was increased with nab-paclitaxel, with more frequent and earlier dose reductions.ConclusionIn patients with chemotherapy-naive advanced BC, ixabepilone once per week was inferior to paclitaxel, and nab-paclitaxel was not superior with a trend toward inferiority. Toxicity was increased in the experimental arms, particularly for nab-paclitaxel. Paclitaxel once per week remains the preferred palliative chemotherapy in this setting.
High Graft CD8 Cell Dose Predicts Improved Survival and Enables Better Donor Selection in Allogeneic Stem-Cell Transplantation With Reduced-Intensity Conditioning
Authors: Reshef Ran , Huffman Austin P. , Gao Amy , Luskin Marlise R. , Frey Noelle V. , Gill Saar I. , Hexner Elizabeth O. , Kambayashi Taku , Loren Alison W. , Luger Selina M. , Mangan James K. , Nasta Sunita D. , Richman Lee P. , Sell Mary , Stadtmauer Edward A. , Vonderheide Robert H. , Mick Rosemarie , Porter David L. 
Published: June 2015

Purpose To characterize the impact of graft T-cell composition on outcomes of reduced-intensity conditioned (RIC) allogeneic hematopoietic stem-cell transplantation (alloHSCT) in adults with hematologic malignancies. Patients and Methods We evaluated associations between graft T-cell doses and outcomes in 200 patients who underwent RIC alloHSCT with a peripheral blood stem-cell graft. We then studied 21 alloHSCT donors to identify predictors of optimal graft T-cell content. Results Higher CD8 cell doses were associated with a lower risk for relapse (adjusted hazard ratio [aHR], 0.43; P = .009) and improved relapse-free survival (aHR, 0.50; P = .006) and overall survival (aHR, 0.57; P = .04) without a significant increase in graft-versus-host disease or nonrelapse mortality. A cutoff level of 0.72 × 108 CD8 cells per kilogram optimally segregated patients receiving CD8hi and CD8lo grafts with differing overall survival (P = .007). Donor age inversely correlated with graft CD8 dose. Consequently, older donors were unlikely to provide a CD8hi graft, whereas approximately half of younger donors provided CD8hi grafts. Compared with recipients of older sibling donor grafts (consistently containing CD8lo doses), survival was significantly better for recipients of younger unrelated donor grafts with CD8hi doses (P = .03), but not for recipients of younger unrelated donor CD8lo grafts (P = .28). In addition, graft CD8 content could be predicted by measuring the proportion of CD8 cells in a screening blood sample from stem-cell donors. Conclusion Higher graft CD8 dose, which was restricted to young donors, predicted better survival in patients undergoing RIC alloHSCT.
Oxygen safety margins set thermal limits in an insect model system
Authors: Boardman Leigh , Terblanche John S. 
Published: June 2015

ABSTRACT
A mismatch between oxygen availability and metabolic demand may constrain thermal tolerance. While considerable support for this idea has been found in marine organisms, results from insects are equivocal and raise the possibility that mode of gas exchange, oxygen safety margins and the physico-chemical properties of the gas medium influence heat tolerance estimates. Here, we examined critical thermal maximum (CTmax) and aerobic scope under altered oxygen supply and in two life stages that varied in metabolic demand in Bombyx mori (Lepidoptera: Bombycidae). We also systematically examined the influence of changes in gas properties on CTmax. Larvae have a lower oxygen safety margin (higher critical oxygen partial pressure at which metabolism is suppressed relative to metabolic demand) and significantly higher CTmax under normoxia than pupae (53°C vs 50°C). Larvae, but not pupae, were oxygen limited with hypoxia (2.5 kPa) decreasing CTmax significantly from 53 to 51°C. Humidifying hypoxic air relieved the oxygen limitation effect on CTmax in larvae, whereas variation in other gas properties did not affect CTmax. Our data suggest that oxygen safety margins set thermal limits in air-breathing invertebrates and the magnitude of this effect potentially reconciles differences in oxygen limitation effects on thermal tolerance found among diverse taxa to date.
Management Approach to the Interaction of Research Centers and Universities in the Economy of the Future
Authors: Варфаловская  , Varfalovskaya R. 
Published: June 2015

Currently network communications play a big role in the economic development of Russian regions. This
structure of economic landscape leads to association of industrial enterprises and educational institutions
into training and production centers, consortia, and clusters providing fruitful interaction between partners.
Regional system of education is a model, the content of which must be gathered through social and stateprivate
partnerships, including those with Universities. Management strategy of scientific and educational
cluster is determined by social, economic, and pedagogical factors. The task of the cluster is creating a
competitive system of professional education for successful development of production management.
The usfulness of the SLUMS test for diagnosis of mild cognitive impairment and dementia
Authors: Szcześniak Dorota , Rymaszewska Joanna 
Published: June 2015

CelCelem pracy jest porównanie polskiej wersji testu The Saint Louis University Mental Status Examination z wystandaryzowanymi przesiewowymi narzędziami psychometrycznymi w detekcji łagodnych zaburzeń poznawczych i otępienia.MetodaW badaniu wzięło udział 58 mieszkańców domów pomocy społecznej, którzy zostali podzieleni na trzy grupy: osób nie ujawniających objawów otępienia, z podejrzeniem łagodnych zaburzeń poznawczych oraz z podejrzeniem otępienia. Wyniki testu The Saint Louis University Mental Status Examination (SLUMS) porównano z wynikami w testach Krótkiej Skali Oceny Stanu Psychicznego (MMSE), Krótkiego Testu Stanu Psychicznego (STMS) oraz testu Sprawdź Swoją Pamięć (TYM).WynikiŚredni wiek osób badanych wynosił 81,7 ± 8,62. W odniesieniu do poziomu edukacji, 37,9% ukończyło szkołę podstawową, 31% miało wykształcenie średni, natomiast 22,4% - wykształcenie wyższe. Wewnętrzna rzetelność testu SLUMS wynosiła 0,7031. Średni wynik w teście SLUMS u osób bez objawów otępienia wynosił 23,3 pkt., 19,3 pkt. u badanych z grupy zaburzeń poznawczych oraz 13,1 pkt. u osób z podejrzeniem otępienia. W porównaniu międzygrupowym powyższe wyniki różniły się istotnie statystycznie, pomiędzy osobami z podejrzeniem otępienia oraz z zaburzeniami poznawczymi (p = 0,01), podobnie w porównaniu do grupy nie ujawniającej objawów otępienia (p = 0,0001). Co więcej, test SLUMS stanowi przydatne narzędzie w różnicowaniu łagodnych zaburzeń poznawczych w grupie osób bez objawów (p = 0,017), podczas gdy wyniki skali MMSE nie dają takiej możliwości (p = 0,51).WnioskiWydaje się, że test SLUMS może stanowić skuteczną alternatywę dla powszechnie stosowanego testu MMSE oraz efektywne narzędzie przydatne w detekcji łagodnych zaburzeń poznawczych, a nie jedynie rozszerzyć wachlarz możliwych do stosowania narzędzi przesiewowych.
Does the Firm Information Environment Influence Financing Decisions? A Test Using Disclosure Regulation
Authors: Albring Susan , Banyi Monica , Dhaliwal Dan , Pereira Raynolde 
Published: June 2015

Extant theory claims a firm’s information environment impacts the choice between debt and equity financing. However, empirical evidence supporting this contention is limited. We evaluate this relation within the context of Regulation Fair Disclosure (Reg FD), which prohibited the use of selective disclosure. We find that firms with high proprietary costs of public disclosure are more likely to resort to debt financing following the passage of Reg FD. This relation is not sensitive to whether a firm has relied on selective disclosure in the pre-Reg FD regime. We also evaluate changes in firm disclosure policy and find that firms that adopted an expansive public disclosure policy are more likely to turn to equity financing. Overall, our evidence is consistent with the pecking order theory: firms with deteriorated firm information environments increase their use of less information-sensitive debt, whereas firms with improved information environments favor the use of equity financing. This paper was accepted by Mary Barth, accounting.
Hedging Flood Losses Using Cat Bonds
Authors: Têtu Alexandre , Lai Van Son , Soumaré Issouf , Gendron Michel 
Published: June 2015

Abstract
In this paper, we develop a methodology to model the risk of losses resulting from a natural disaster in which the intensity parameter of the non-homogeneous Poisson process has an upward trend and a seasonal component. We apply this model to losses due to floods in the Financial Assistance Program of the Government of Quebec (Canada). We use the historically observed risk premiums to assess the financial costs for the government if it had issued such instruments to hedge risk linked to floods.
Reference intervals for 24 laboratory parameters determined in 24-hour urine collections
Authors: Curcio Raffaele , Stettler Helen , Suter Paolo M. , Aksözen Jasmin Barman , Saleh Lanja , Spanaus Katharina , Bochud Murielle , Minder Elisabeth , von Eckardstein Arnold 
Published: June 2015

AbstractReference intervals for many laboratory parameters determined in 24-h urine collections are either not publicly available or based on small numbers, not sex specific or not from a representative sample.Osmolality and concentrations or enzymatic activities of sodium, potassium, chloride, glucose, creatinine, citrate, cortisol, pancreatic α-amylase, total protein, albumin, transferrin, immunoglobulin G, αBy contrast to most published reference intervals, which do not stratify for sex, reference intervals of 12 of 24 laboratory parameters in 24-h urine collections and of eight of 16 parameters as creatinine-normalized ratios differed significantly between men and women. For six parameters calculated as 24-h urine excretion and four parameters calculated as creatinine-normalized ratios no reference intervals had been published before. For some parameters we found significant and relevant deviations from previously reported reference intervals, most notably for 24-h urine cortisol in women. Ten 24-h urine parameters showed weak or moderate sex-specific correlations with age.By applying up-to-date analytical methods and clinical chemistry analyzers to 24-h urine collections from a large population-based cohort we provide as yet the most comprehensive set of sex-specific reference intervals calculated according to CLSI guidelines for parameters determined in 24-h urine collections.
Wall-crossing in genus zero Landau–Ginzburg theory
Authors: Ross Dustin , Ruan Yongbin 
Published: June 2015

Abstract
We study a family of moduli spaces and corresponding quantum invariants introduced recently by Fan–Jarvis–Ruan. The family has a wall-and-chamber structure relative to a positive rational parameter ϵ. For a Fermat quasi-homogeneous polynomial W (not necessarily of Calabi–Yau type), we study natural generating functions packaging the invariants. Our wall-crossing formula relates the generating functions by showing that they all lie on the Lagrangian cone associated to the Fan–Jarvis–Ruan–Witten theory of W. For arbitrarily small parameter ϵ, a specialization of our generating function is a hypergeometric series called the big I-function which determines the entire Lagrangian cone. As a special case of our wall-crossing, we obtain a new geometric interpretation of the Landau–Ginzburg mirror theorem.
Vitamin D3 in cancer prevention and therapy: the nutritional issue
Authors: Chirumbolo Salvatore 
Published: June 2015

Abstract
The action of vitamin D3, in its biological form 1α,25(OH)2vitD3 or calcitriol, may be summarized as a steroid-like hormone able to modulate basic functions of cell encompassing energy balance, stress response, mitochondria biogenesis, intracellular calcium oscillations, and replication/apoptosis mechanisms leading to cell survival. Moreover, calcitriol exerts a potent role as an innate and adaptive immune cytokine as immunity is closely related to self-maintenance through its energetic/metabolic balance and homeostasis of cell turnover. Therefore, vitamin D might be the ancestral form of survival hormones developed with calcified vertebrate bearing skeleton in order to survive far from water. This characteristic may suggest that the role of dietary vitamin D in preventing cancer is simply ancillary to the many factors playing a major role in contrasting impairment in energy balance and cell survival. Most probably, the immune role of calcitriol might be included in the maintenance, mostly by adipose tissue, of an anti-inflammatory, tolerant immune status, depending on the immune tolerance and modulation from the gut. A balance closely modulated by the leptin axis, which when impairments in metabolism occur, such as in insulin resistance or obesity, calcitriol is unable to face at this imbalance, while leptin plays a major role and cancer progression may be promoted. Furthermore, this mechanism promotes epithelial/mesenchymal transition-mediated fibrosis, leading to cancer resistance to immune control and drug action. Interestingly, this pathologic picture is triggered by deficiency in vitamin D from the diet. Therefore, a dietary habit including vitamin D sources, besides flavonoids, may ameliorate lifestyle and health span in most individuals, depending on their genetic background.
Separation Of Non-Periodic And Periodic 2D Profile Features Using B-Spline Functions
Authors: Janecki Dariusz , Cedro Leszek , Zwierzchowski Jarosław 
Published: June 2015

Abstract
The form, waviness and roughness components of a measured profile are separated by means of digital filters. The aim of analysis was to develop an algorithm for one-dimensional filtering of profiles using approximation by means of B-splines. The theory of B-spline functions introduced by Schoenberg and extended by Unser et al. was used. Unlike the spline filter proposed by Krystek, which is described in ISO standards, the algorithm does not take into account the bending energy of a filtered profile in the functional whose minimization is the principle of the filter. Appropriate smoothness of a filtered profile is achieved by selecting an appropriate distance between nodes of the spline function. In this paper, we determine the Fourier transforms of the filter impulse response at different impulse positions, with respect to the nodes. We show that the filter cutoff length is equal to half of the node-to-node distance. The inclination of the filter frequency characteristic in the transition band can be adjusted by selecting an appropriate degree of the B-spline function. The paper includes examples of separation of 2D roughness, as well as separation of form and waviness of roundness profiles.
Faults Classification Of Power Electronic Circuits Based On A Support Vector Data Description Method
Authors: Cui Jiang 
Published: June 2015

Abstract
Power electronic circuits (PECs) are prone to various failures, whose classification is of paramount importance. This paper presents a data-driven based fault diagnosis technique, which employs a support vector data description (SVDD) method to perform fault classification of PECs. In the presented method, fault signals (e.g. currents, voltages, etc.) are collected from accessible nodes of circuits, and then signal processing techniques (e.g. Fourier analysis, wavelet transform, etc.) are adopted to extract feature samples, which are subsequently used to perform offline machine learning. Finally, the SVDD classifier is used to implement fault classification task. However, in some cases, the conventional SVDD cannot achieve good classification performance, because this classifier may generate some so-called refusal areas (RAs), and in our design these RAs are resolved with the one-against-one support vector machine (SVM) classifier. The obtained experiment results from simulated and actual circuits demonstrate that the improved SVDD has a classification performance close to the conventional one-against-one SVM, and can be applied to fault classification of PECs in practice.
New Indicators Of Burnished Surface Evaluation – Reasons Of Application
Authors: Toboła Daniel , Rusek Piotr , Czechowski Kazimierz , Miller Tatiana , Duda Krzysztof 
Published: June 2015

Abstract
Modern production technology requires new ways of surface examination and a special kind of surface profile parameters. Industrial quality inspection needs to be fast, reliable and inexpensive. In this paper it is shown how stochastic surface examination and its proper parameters could be a solution for many industrial problems not necessarily related with smoothing out a manufactured surface. Burnishing is a modern technology widely used in aircraft and automotive industries to the products as well as to process tools. It gives to the machined surface high smoothness, and good fatigue and wear resistance. Every burnished material behaves in a different manner. Process conditions strongly influence the final properties of any specific product. Optimum burnishing conditions should be preserved for any manufactured product. In this paper we deal with samples made of conventional tool steel – Sverker 21 (X153CrMoV12) and powder metallurgy (P/M) tool steel – Vanadis 6. Complete investigations of product properties are impossible to perform (because of constraints related to their cost, time, or lack of suitable equipment). Looking for a global, all-embracing quality indicator it was found that the correlation function and the frequency analysis of burnished surface give useful information for controlling the manufacturing process and evaluating the product quality. We propose three new indicators of burnishing surface quality. Their properties and usefulness are verified with the laboratory measurement of material samples made of the two mentioned kinds of tool steel.