bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile Synthesis of Derivatives of 1,1,3‐Trioxo‐2H,4H‐pyrrolo[1,2‐b][1,2,4,6]thiatriazine: A New Heterocyclic System
Authors: Chen Wenmin , Zhan Peng , Rai Diwakar , Huang Boshi , Yang Jiapei , Liu Xinyong 
Published: October 2013

ABSTRACTWe reported a facile and efficient methodology to synthesize derivatives of pyrrolo[1,2‐b][1,2,4,6]thiatriazine (PTTD): a new bridgehead nitrogen heterocyclic system. Treatment of methyl pyrrole‐2‐carboxylate with N‐benzylsulfamoyl chlorides followed by subsequent hydrolysis reaction afforded 1‐benzylsulfamoyl‐1H‐pyrrole‐2‐carboxylic acids, which underwent ring‐closing reaction by treatment with diphenyl phosphorazidate via Curtius rearrangement; subsequent alkylation reaction afforded the desired 2,4‐disubstituted‐1,1,3‐trioxo‐2H,4H‐PTTDs.
The Effect of Medicaid Policies on the Diagnosis and Treatment of Children's Mental Health Problems in Primary Care
Authors: Turner Lesley J. 
Published: October 2013

SummaryPrimary care physicians play a substantial role in diagnosing and treating children's mental health disorders, but Medicaid managed care policies may limit these physicians' ability to serve low‐income children. Using data from the universe of Medicaid recipients in three states, I evaluate how Medicaid managed care policies impact primary care diagnosis and treatment of children's mental health disorders. Specific policies examined include the presence of a behavioral carve‐out, traditional health maintenance organization, or primary care case management program. To alleviate concerns of endogenous patient sorting, my preferred identification strategy uses variation in Medicaid policy penetration to instrument for individual plan choices. I show that while health maintenance organizations reduce diagnosis and non‐drug treatment of mental health disorders, primary care case management program policies shift in diagnosis and treatment from within primary care to specialist providers such as psychiatrists, where serious mental health conditions are more likely to be identified. Copyright © 2013 John Wiley & Sons, Ltd.
Inherently poor survival of elderly patients with nasopharyngeal carcinoma
Authors: Zhang Ye , Yi Jun‐Lin , Huang Xiao‐Dong , Xu Guo‐Zhen , Xiao Jian‐Ping , Li Su‐Yan , Luo Jing‐Wei , Zhang Shi‐Ping , Wang Kai , Qu Yuan , Gao Li 
Published: October 2013

AbstractBackgroundThe purpose of this study was to determine the features of the elderly patient with nasopharyngeal carcinoma (NPC).MethodsThe medical records of 212 patients with NPC, aged ≥65 years, and receiving radiotherapy were retrospectively reviewed. Comorbidity was rated using the Charlson Comorbidity Index (CCI).ResultsTwenty‐four patients (11.3%) scored ≥3 and 188 patients (88.7%) scored <3 rated by CCI. The median actuarial irradiated dose of the nasopharynx was 72 Gy (range, 20–94 Gy) with 87.3% patients receiving >70 Gy. One hundred fifty‐four patients had stage III/IV disease. The actuarial local control, cancer‐specific survival (CSS), and overall survival (OS) rates at 5 years were 68.8%, 63.5%, and 47.0%, respectively. On multivariate analysis, stage (hazard ratio [HR], 1.489; 95% confidence interval [CI], 1.168–1.897; p = .001), the technique of radiotherapy (HR, 0.674; 95% CI, 0.476–0.953; p = .025), and anemia (HR, 3.081; 95% CI, 1.624–5.845; p = .001) were independent prognostic factors.ConclusionThe elderly patients with NPC may inherently predict poor outcomes. © 2015 Wiley Periodicals, Inc. Head Neck 37: 771–776, 2015
Long‐term functional and quality of life evaluation after treatment for advanced pharyngolaryngeal carcinoma
Authors: Metreau Alexandre , Louvel Guillaume , Godey Benoît , Le Clech Guy , Jegoux Franck 
Published: October 2013

AbstractBackgroundThe purpose of this study was to compare total laryngectomy versus concurrent chemoradiotherapy (CRT) for functional and long‐term quality of life (QOL) outcomes in patients with pharyngolaryngeal carcinoma.MethodsAmong 145 patients treated for advanced pharyngolaryngeal cancer by CRT or total laryngectomy between 2000 and 2008, 47 patients who had completed treatment for >1 year and were determined to be disease‐free were evaluated for function and QOL using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire‐Core 30‐questions (EORTC‐QLQ‐C30).ResultsNo significant difference was observed between the total laryngectomy group (26 patients) and the CRT group (21 patients) concerning feeding tube (p = .72), oral supplements (p = .84), and pneumonia (p = 1.00). Laryngeal functional rate after CRT was 72% at 2 years. No significant difference was observed between the 2 groups when using EORTC‐QLQ‐C30 scales (p > .05). According to the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire‐Core 30 Head and Neck 35‐questions (EORTC‐QLQ‐C30‐H&N35) questionnaire, surgical patients reported significantly greater difficulties with smell and taste (p = .005) and chemoradiation patients with dry mouth (p = .010) and weight loss (p = .022). Differences that seemed clinically meaningful but not statistically significant emerged on several other scales.ConclusionBoth total laryngectomy and CRT led to a similar high rate of dysphagia‐related morbidity (feeding tube, oral supplements, and pneumonia) and QOL alteration, but the groups differed in the specific QOL domains affected. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1604–1610, 2014
Role of endolaryngeal surgery (with or without laser) versus radiotherapy in the management of early (T1) glottic cancer: A systematic review
Authors: Yoo John , Lacchetti Christina , Hammond J. Alex , Gilbert Ralph W. ,   Head and Neck Cancer Disease Site Group
Published: October 2013

AbstractBackgroundTreatment options for early glottic cancer include transoral microsurgery or radiotherapy (RT). There is continuing debate about which is the superior treatment.MethodsThe literature was searched from 1996 to 2011 using MEDLINE, EMBASE, and Cochrane Library. A quality assessment of each included study was conducted and reported.ResultsThere is no evidence in favor of 1 treatment modality when considering likelihood of local control or overall survival. There is a suggestion that RT may be associated with less measureable perturbation of voice as compared to surgery, but no significant differences were seen in patient perception. The likelihood of laryngeal preservation may be higher when surgery can be offered as initial treatment.ConclusionFor patients with early (T1) glottic cancer, treatment options include the equally effective endolaryngeal surgery, with or without laser, or radiation therapy. The choice between treatment modalities should be based on patient and clinician preferences and general medical condition. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1807–1819, 2014
TPF induction chemotherapy and concomitant irradiation with cisplatin and cetuximab in unresectable squamous cell carcinoma of the head and neck
Authors: Strojan Primož , Kuhar Cvetka Grašič , Žumer Barbara , Kadivec Maksimilijan , Karner Katarina , Fajdiga Igor , Jančar Boris , Gale Nina , Poljak Mario , Kocjan Boštjan J , Zakotnik Branko 
Published: October 2013

AbstractBackgroundThe purpose of this study was to assess the efficacy and toxicity of docetaxel, cisplatin/5‐fluorouracil (TPF) induction chemotherapy and concomitant immunochemoradiotherapy with cetuximab and cisplatin in unresectable head and neck carcinoma.MethodsTreatment consisted of TPF induction chemotherapy (docetaxel 75 mg/m2 day 2; cisplatin, 75 mg/m2 day 2; and 5‐fluorouracil 750 mg/m2 days 1–4; 4 cycles), followed by radiotherapy (RT) and concomitant weekly cetuximab, (250 mg/m2, after a loading dose of 400 mg/m2) and cisplatin (30 mg/m2).ResultsTwenty‐five of 30 patients completed 4 cycles of induction chemotherapy. Six or more concomitant infusions of cisplatin and cetuximab were administered in 13 of 25 and 18 of 25 patients, respectively. The 2‐year locoregional control, disease‐free survival (DFS), and overall survival (OS) were 47%, 47%, and 50%, respectively. Patients with grade ≥2 skin reaction to cetuximab had a superior outcome.ConclusionThe tested regimen was effective; however, cetuximab and low‐dose cisplatin after induction TPF increased the treatment toxicity. A grade ≥2 skin rash correlated with improved efficacy. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1555–1561, 2014
Bone impacted fibular free flap: A novel technique to increase bone density for dental implantation in osseous reconstruction
Authors: Dziegielewski Peter T. , Mlynarek Alex M. , Harris Jeffrey R. , Hrdlicka Adam , Barber Brittany , Al‐Qahtani Khalid , Wolfaardt John , Raboud Don , Seikaly Hadi 
Published: October 2013

AbstractBackgroundFibular free flap (FFF) bone has thick cortical bone surrounding a fatty marrow. The cortex has sufficient density for dental implantation, but the marrow limits bone stock. A novel technique was devised to increase bone density: the bone‐impacted fibular free flap (BIFFF). The purpose of this study was to: (1) describe the BIFFF technique; (2) evaluate the bone density of BIFFF; and (3) evaluate the stability/success of implants placed in BIFFFs.MethodsPatients undergoing maxillary/mandibular reconstruction with FFFs were prospectively enrolled from 1998 to 2008. Two cohorts were compared: BIFFF and nonmodified FFF. The main outcome was bone density as seen on CT scans. Primary dental implant stability was determined via Periotest.ResultsThirty‐eight patients were included in this study. BIFFFs achieved higher bone density versus unmodified FFFs (p < .05). Greater primary dental implant stability occurred in BIFFFs (p < .05). One hundred percent of BIFFF and 59% of nonmodified FFF implants were successful at 1 year.ConclusionBIFFF increases reconstructed bone density, initial dental implant stability, and 1‐year implant success. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1648–1653, 2014
Radiographic extracapsular extension and treatment outcomes in locally advanced oropharyngeal carcinoma
Authors: Kann Benjamin H. , Buckstein Michael , Carpenter Todd J. , Bakst Richard , Misiukiewicz Krzysztof , Genden Eric , Posner Marshall , Kostakoglu Lale , Som Peter , Gupta Vishal 
Published: October 2013

AbstractBackgroundPathologic extracapsular extension (pECE) in metastatic lymph nodes is associated with poor prognosis for oropharyngeal carcinoma. The prognostic value of radiographic extracapsular extension (rECE) has not been studied.MethodsA retrospective analysis was conducted of 111 patients with locally advanced oropharyngeal carcinoma treated in the Mount Sinai Radiation Oncology Department with accessible pretreatment CT reports. Univariate Kaplan–Meier and multivariate Cox regression analyses compared cohorts for locoregional control, distant control, progression‐free (PFS), and overall survival (OS).ResultsSixty‐four patients had rECE‐present and 47 had rECE‐absent scans. The patients with rECE presence had significantly worse OS (3‐year: 95% vs 77%; p = .006), PFS (3‐year: 91% vs 71%; p = .002), and distant control (3‐year: 98% vs 81%; p = .008), with no difference in locoregional control. On multivariate analysis, rECE‐presence was a negative prognosticator for OS, PFS, and distant control.ConclusionThis study suggests that rECE is an independent prognosticator of poor distant control and survival with little impact on locoregional control for oropharyngeal carcinoma. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1689–1694, 2014
A New Role for IKK-α in Hepatitis C Virus-Induced Lipogenesis
Authors: Douglas Mark W. , Esmaili Saeed , George Jacob 
Published: October 2013

Abstract

Hepatitis C virus (HCV) interacts extensively with host factors to not only establish productive infection but also trigger unique pathological processes. Our recent genome-wide siRNA screen demonstrated that IκB kinase-α (IKK-α) is a crucial host factor for HCV. Here we describe a new nuclear factor κB (NF-κB)-independent and kinase-mediated nuclear function of IKK-α in HCV assembly. HCV, through its 3′ untranslated region, interacts with DEAD box polypeptide 3, X-linked (DDX3X) to activate IKK-α, which translocates to the nucleus and induces a CBP/p300-mediated transcriptional program involving sterol regulatory element-binding proteins (SREBPs). This innate pathway induces lipogenic genes and enhances core-associated lipid droplet formation to facilitate viral assembly. Chemical inhibitors of IKK-α suppress HCV infection and IKK-α-induced lipogenesis, offering a proof-of-concept approach for new HCV therapeutic development. Our results show that HCV uses a novel mechanism to exploit intrinsic innate responses and hijack lipid metabolism, which may contribute to high chronicity rates and the pathological hallmark of steatosis in HCV infection.
The combined expression of VPREB3 and ID3 represents a new helpful tool for the routine diagnosis of mature aggressive B‐cell lymphomas
Authors: Soldini Davide , Georgis Antoin , Montagna Chiara , Schüffler Peter Johannes , Martin Vittoria , Curioni‐Fontecedro Alessandra , Martinez Antonio , Tinguely Marianne 
Published: October 2013

AbstractGenomic studies, such as gene expression profiling and next‐generation sequencing studies, have provided new insights into the phenotypic characteristics and pathogenesis of mature aggressive B‐cell lymphomas. In particular, mutations in the transcription factors ID3 and TCF3, leading to overexpression of B‐cell receptor components such as VPREB3, have been shown to be specific for Burkitt lymphoma (BL) and play an important tumourigenic role by mediating the activation of the pro‐survival phosphatidylinositol‐3‐OH kinase pathway. We performed immunohistochemical analysis by applying commercially available anti‐VPREB3 antibody to a large cohort of 185 genetically and immunophenotypically characterized mature aggressive B‐cell lymphomas and analyzed these results together with recent data on ID3 expression. The combined expression of both VPREB3 and ID3 was associated with a diagnosis of BL with high sensitivity (0.77), high specificity (0.75) and high negative predictive values (0.96), however, with lower positive predictive value (0.30). Double negative cases were absent in the group of BLs but could be found in approximately one third of the remaining cases of mature aggressive B‐cell lymphomas. Further, we could not identify a correlation with MYC, BCL2 or BCL6 aberrations with neither VPREB3 nor ID3 expression in each of the diagnostic groups analyzed. Our results, which are in line with recently discovered mutations in next‐generation sequencing studies, suggest that the combined immunohistochemical detection of VPREB3 and ID3 is applicable to the routine diagnostic in case of mature aggressive B‐cell lymphomas. In particular, it represents a useful and routinely applicable diagnostic tool to exclude BL diagnosis in case of single positive or double negative cases. Copyright © 2013 John Wiley & Sons, Ltd.
Treatment of gastric marginal zone B‐cell lymphoma of the mucosa‐associated lymphoid tissue with rituximab, cyclophosphamide, vincristine and prednisone
Authors: Aguiar‐Bujanda David , Llorca‐Mártinez Ignacio , Rivero‐Vera José C. , Blanco‐Sánchez María J. , Jiménez‐Gallego Pedro , Mori‐De Santiago Marta , Limeres‐Gonzalez Miguel A. , Cabrera‐Marrero José C. , Hernández‐Sosa María , Galván‐Ruíz Saray , Hernández‐Sarmiento Samuel , Saura Grau Salvador , Bohn‐Sarmiento Uriel 
Published: October 2013

AbstractThere is no standard treatment for patients with gastric marginal zone B‐cell lymphoma of the mucosa‐associated lymphoid tissue (MALT lymphoma) who are resistant to, or ineligible for, anti‐Helicobacter pylori (anti‐HP) therapy. In this study, we investigated the activity of the rituximab, cyclophosphamide, vincristine and prednisone (R‐CVP) regimen in patients with gastric MALT lymphoma. Patients were included provided they had untreated gastric MALT lymphoma (except for anti‐HP therapy) and were resistant to, or ineligible for, anti‐HP therapy. Treatment plan consisted of six to eight 21‐day cycles of the R‐CVP chemotherapy regimen. Toxicity, response, relapse and survival were evaluated. Twenty patients (12 women and 8 men) were included in the analyses with median age of 59 years. Thirteen patients (65%) had stage I tumours, and seven patients (35%) had stages II–IV tumours. The overall response rate was 100%, with 19 (95%) complete responses and one (5%) partial response. Regimen toxicity was mild and mainly hematological, and no cases of gastric bleeding or perforation occurred. After a median follow‐up of 56.3 months, three patients had relapsed, and 19 patients remained alive (specific lymphoma survival 100%), of whom 17 had no evidence of disease. In our experience, the R‐CVP regimen is a well‐tolerated and effective treatment for patients with gastric MALT lymphoma who are resistant to, or ineligible for, anti‐HP therapy. Copyright © 2013 John Wiley & Sons, Ltd.
The effects of user fees on quality and utilization of primary health‐care services in Afghanistan: a quasi‐experimental health financing pilot study in a post‐conflict setting
Authors: Steinhardt Laura C. , Rao Krishna D. , Hansen Peter M. , Alam Sahibullah , Peters David H. 
Published: October 2013

SUMMARYBackgroundAfter the fall of the Taliban regime, most clinics in Afghanistan were charging fees to patients. The government invested in monitoring and evaluation systems for its newly rebuilt primary care system, but little was known about the effects of user fees. This study was undertaken to provide evidence on user fees' effects on quality and service utilization and to help inform development of health financing policy and strategy.MethodsA quasi‐experimental health financing pilot study was implemented in 2005. Forty‐seven facilities were randomized to implement a standardized user fee intervention, offer free services, or serve as controls, continuing current cost‐sharing systems. Revenues were co‐managed by staff and community leaders for facility improvement. Baseline and follow‐up facility assessments, exit interviews, and household surveys, as well as routine data were used to evaluate user fee effects over 2 years.ResultsObserved and perceived quality improved at most facilities but did not differ by study group. Utilization increased in all groups, but the increase was 682 to 748 visits per month larger in facilities randomized to free services compared with those randomized to fees or controls (p < 0.01).ConclusionUser fees demonstrated few beneficial effects and slowed the rate of increase of service utilization in Afghanistan. In 2008, the government abolished primary care fees, citing results of this study. Copyright © 2013 John Wiley & Sons, Ltd.
Unsteady MHD Mixed Convective Boundary‐Layer Slip Flow and Heat Transfer with Thermal Radiation and Viscous Dissipation
Authors: Ibrahim Wubshet , Shanker Bandari 
Published: October 2013

AbstractA numerical analysis has been carried out to investigate the problem of MHD boundary‐layer flow and heat transfer of a viscous incompressible fluid over a moving vertical permeable stretching sheet with velocity and temperature slip boundary condition. A problem formulation is developed in the presence of radiation, viscous dissipation, and buoyancy force. A similarity transformation is used to reduce the governing boundary‐layer equations to coupled higher‐order nonlinear ordinary differential equations. These equations are solved numerically using the fourth‐order Runge–Kutta method along with shooting technique. The effects of the governing parameters such as Prandtl number, buoyancy parameter, slip parameter, magnetic parameter, Eckert Number, suction, and radiation parameter on the velocity and temperature profiles are discussed and shown by plotting graphs. It is found that the temperature is a decreasing function of the slip parameter ST. The results also indicate that the cooling rate of the sheet can be improved by increasing the buoyancy parameter. In addition the numerical results for the local skin friction coefficient and local Nusselt number are computed and presented in tabular form. The numerical results are compared and found to be in good agreement with previously published results on special cases of the problem. © 2013 Wiley Periodicals, Inc. Heat Trans Asian Res, 43(5): 412–426, 2014; Published online 3 October 2013 in Wiley Online Library (wileyonlinelibrary.com/journal/htj). DOI 10.1002/htj.21086
Water balance of a burned and unburned forested boreal peatland
Authors: Thompson Dan K. , Benscoter Brian W. , Waddington James M. 
Published: October 2013

AbstractWe examined the water balance of a forested ombrotrophic peatland and adjacent burned peatland in the boreal plain of western Canada over a 3‐year period. Complete combustion of foliage and fine branches dramatically increased shortwave radiation inputs to the peat surface while halting all tree transpiration at the burned site. End‐of‐winter snowpack was 7–25% higher at the burned site likely due to decreased ablation from the tree canopy at the unburned site. Shrub regrowth at the burned site was rapid post‐fire, and shading by the shrub canopy in the burned site approached that of the unburned site within 3 years after fire. Site‐averaged surface resistance to evaporation was not different between sites, though surface resistance in hollows was lower in the burned site. Water loss at both burned and unburned sites is largely driven by surface evaporative losses. Evaporation at the burned site marginally exceeded the sum of pre‐fire transpiration and interception at the unburned site, suggesting that evapotranspiration during the growing season was 20–40 mm greater at the burned peatland. Although the net change in water storage during the growing season was largely unchanged by fire, the lack of low‐density surface peat in the burned site appears to have decreased specific yield, leading to greater water table decline at the burned site despite similar net change in storage. Copyright © 2013 John Wiley & Sons, Ltd.
The impact of the South–North Water Transfer Project (CTP)'s central route on groundwater table in the Hai River basin, North China
Authors: Ye Aizhong , Duan Qingyun , Chu Wei , Xu Jing , Mao Yuna 
Published: October 2013

AbstractThe central route of the South–North Water Transfer Project (CTP) is designed to divert approximately 9.5 billion m3 of water per year from the Han River, a major tributary of the Yangtze River, to the Hai River basin in the north China. The main purpose of this study is to assess the impact of CTP on groundwater table in the Hai River basin. Our study features a large‐scale distributed hydrological model that couples a physically based groundwater module, which is sub‐basin‐based, with a conceptual surface water module, which is grid‐based. There are several grids in each sub‐basin and water exchange among grid that are considered. Our model couples surface water module and groundwater module and calculates human water use at the same time. The simulation results indicate that even with the water supply by CTP, the groundwater table will continue to decline in the Hai River basin. However, the CTP water can evidently reduce the decline rate, helping alleviate groundwater overexploitation in Hai River region. Copyright © 2013 John Wiley & Sons, Ltd.