bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term Clinical and Radiographic Results After Delayed Anterior Cruciate Ligament Reconstruction in Adolescents
Authors: Månsson Olle , Sernert Ninni , Rostgard-Christensen Lars , Kartus Jüri 
Published: November 2014

Background: The risk of further intra-articular damage associated with nonoperative or delayed anterior cruciate ligament (ACL) reconstruction must be considered against the risk of growth disturbance with early reconstruction and transphyseal drilling. Long-term follow-ups after the surgical treatment of ACL injuries in adolescents are rare. Purpose: To evaluate results 10 to 20 years after ACL reconstruction in terms of the radiographic presence of osteoarthritis, clinical assessments, and health-related quality of life in patients who were adolescents at the time of surgery. Study Design: Case series; Level of evidence, 4. Methods: Thirty-two adolescents (mean age, 15.2 years [range, 12-16 years]; 11 boys, 21 girls), with a symptomatic unilateral ACL rupture, underwent reconstruction using bone–patellar tendon–bone (n = 10) or hamstring tendon (n = 22) autografts at an almost skeletally mature age according to Tanner stage 4. Twenty-nine patients (91%) underwent clinical, radiographic, and health-related quality of life assessments after 10 to 20 years (mean, 175 months). Results: The mean time between the injury and index surgery was 11.6 months. The reconstructed knee had significantly more osteoarthritic changes compared with the noninvolved contralateral knee ( P = .001). Preoperatively, the median Tegner activity level was 4 (range, 2-8), and the median Lysholm knee score was 75 (range, 50-90) points. At follow-up, the respective median values were 4 (range, 1-7) and 84 (range, 34-100) points ( P = not significant [preoperatively vs follow-up]). The median finding for the single-legged hop test was 84% (range, 0%-105%) preoperatively and 93% (range, 53%-126%) at follow-up ( P = .01). At follow-up, muscle strength measurements displayed more than 90% of the noninvolved leg in both extension and flexion. The manual Lachman test result was significantly improved at follow-up compared with preoperatively ( P < .001). The 36-item Short Form Health Survey (SF-36) revealed scores comparable with those of healthy controls. The mean EuroQol (EQ-5D) score was 0.86 ± 0.12. The Knee injury and Osteoarthritis Outcome Score (KOOS) values were lower in all dimensions compared with age-matched healthy controls. Conclusion: In the long term, patients who were adolescents at the time of ACL reconstruction revealed significantly more radiographically visible osteoarthritic changes in their operated knee than in their noninvolved contralateral knee. Clinical outcomes and health-related quality of life are comparable with those of healthy controls.
The Case for the Perceived Social Competence Scale II
Authors: Anderson-Butcher Dawn , Amorose Anthony J. , Lower Leeann M. , Riley Allison , Gibson Allison , Ruch Donna 
Published: November 2014

Objective: This study examines the psychometric properties of the revised Perceived Social Competence Scale (PSCS), a brief, user-friendly tool used to assess social competence among youth. Method: Confirmatory factor analyses (CFAs) examined the factor structure and invariance of an enhanced scale (PSCS-II), among a sample of 420 youth. Correlations between PSCS-II and self-reported social skill scores were examined. A longitudinal CFA tested the invariance of the factor structure over time with a different sample of 451 youth. Results: The revised 5-item PSCS-II demonstrated acceptable factorial validity, factorial invariance across time and gender as well as strong predictive validity. Conclusion: The PSCS-II was supported as a strengthened version of the PSCS to measure social competence in social work research and practice.
Psychometric Evaluation of the Simplified Chinese Version of Flourishing Scale
Authors: Tang Xiaoqing , Duan Wenjie , Wang Zhizhang , Liu Tianyuan 
Published: November 2014

Objectives: The Flourishing Scale (FS) was developed to measure psychological well-being from the eudaimonic perspective, highlighting the flourishing of human functioning. This article evaluated the psychometric characteristics of the simplified Chinese version of FS among a Chinese community population. Method: A total of 433 participants from 17 different communities in southwest China completed a questionnaire package that included FS, Chinese Virtues Questionnaire, and Brief Symptom Inventory-18. Results: The results demonstrated excellent internal consistency, solid one-factor structure, strong convergent and discriminant validity, and incremental validity. Flourishing was found to play a mediating role in the relationship between total virtue and psychological distress. Conclusions: FS was proved to be appropriate for use in assessing psychological well-being among a Chinese community population, which may be recognized as a promising tool to evaluate the effectiveness of interventions for evidence-based social work practice.
Comparison of laparoscopic and open colonic resection within fast-track and traditional perioperative care pathways: clinical outcomes and in-hospital costs
Authors: Ehrlich A. , Kellokumpu S. , Wagner B. , Kautiainen H. , Kellokumpu I. 
Published: November 2014

Background: This study examined short-term clinical outcomes and in-hospital costs of laparoscopic and open colonic resection within fast-track and traditional care pathways. Material and Methods: A case–control study was performed. From 2007 to 2009, 116 patients underwent laparoscopic or open colonic resection for benign or malignant disease within fast-track care pathway. The control group consisted of 116 age-, sex-, comorbidity-, type of surgery–, and diagnosis-matched patients who received a traditional perioperative care from 2000 to 2007. The main measures of outcome were postoperative hospital stay and in-hospital costs, with 30-day mortality, morbidity, reoperation, and readmission rates as secondary outcomes. Results: The study groups were well balanced for baseline characteristics. Postoperative hospital stay was shorter in the fast-track than in the control group: laparoscopic resection median 3 versus 5 days (p < 0.001) and open resection 4 versus 7 days (p < 0.001). In multivariate analysis fast-track care, laparoscopic surgery and complications were independent determinants affecting the length of hospital stay. Overall, there was a trend toward lower in-hospital costs in the fast-track group compared with the traditional care group, but the difference was not statistically significant. Open surgery within fast-track care was the least costly option compared to laparoscopic or open surgery within traditional care but not significantly so when compared with laparoscopy within fast-track care. Intake of solid food and bowel function recovered 1 day earlier in the fast-track group than in the control group (p < 0.001). Complications were more frequent after open surgery than after laparoscopic surgery (23.3% vs 11.0%, p = 0.012). Reoperation and readmission rates were similar between the study groups. Conclusion: Laparoscopy improves the efficiency of fast-track perioperative care without significantly increasing in-hospital costs.
Distal third humeri fractures treated using the Synthes™ 3.5-mm extra-articular distal humeral locking compression plate: clinical, radiographic and patient outcome scores
Authors: Fawi Hassan , Lewis James , Rao Prasad , Parfitt Dan , Mohanty Khitish , Ghandour Adel 
Published: November 2014

Background Conventional management protocols for distal humeral extra-articular fractures (e.g. conservative, double columnar plating) are often associated with complications. We aimed to describe our experience of using the Synthes™ 3.5-mm extra-articular distal humeral locking compression plate for treatment of extra-articular distal humeral fractures. Methods We prospectively studied 23 consecutive patients who underwent fixation, in a tertiary trauma centre, over 2 years. Data, including patient demographics, duration of follow-up, patient satisfaction, visual analogue score (VAS), Oxford Elbow Score, and final outcome on discharge, were collected and analyzed. Results Of the 23 patients (12 males, 11 females; mean age 47.5 years; range 18 years to 89 years), all fractures united radiologically and clinically after the index procedure, with a mean time to fracture union of 15.7 weeks (range 9 weeks to 34 weeks) and a mean time to discharge of 17.8 weeks (range 13 weeks to 34 weeks). Oxford Elbow Score was 36.5 (range 11 to 48) at 4.6 months postoperatively; at 20 months follow-up, it was 40 (range 14 to 48) and the VAS was 8.5 (range 5 to 10). One patient had radial nerve neuropraxia pre-operatively, and one postoperatively, and both recovered uneventfully 3 months postoperatively. Neither superficial, nor deep infections were observed in this cohort. Conclusions The present study reports satisfactory outcome with the usage of the Synthes plate for extra-articular fracture management. It has become the technique of choice in our centre because it provides excellent results.
Meniscal Repair of Degenerative Horizontal Cleavage Tears Using Fibrin Clots
Authors: Kamimura Tamiko , Kimura Masashi 
Published: November 2014

Background: Presently, the treatment options available for patients with horizontal degenerative cleavage tears of the meniscus are limited. These tears are considered an indication for partial or subtotal meniscectomy because when the tear is located within an avascular area, it is difficult to induce healing. However, meniscectomy is not ideal because it disrupts the normal anatomical structure and function of the meniscus. Purpose: To examine the clinical and arthroscopic outcomes following meniscal repair of degenerative horizontal cleavage tears using fibrin clots. Study Design: Case series; Level of evidence, 4. Methods: Vertical sutures were placed in the meniscal tear, and the cleft was filled with fibrin clots before the sutures were tightened. We repaired 18 menisci in 18 consecutive eligible patients using a previously described technique. Three patients with anterior cruciate ligament (ACL) injury who underwent simultaneous ACL reconstruction and 5 patients who did not undergo follow-up arthroscopy within 12 months were excluded. The remaining 10 menisci in 10 patients were evaluated in this study. The mean age of the patients was 35.8 ± 16.5 years, and the mean postoperative follow-up time was 40.8 ± 5.4 months. Pre- and postoperative Lysholm scores, International Knee Documentation Committee (IKDC) subjective scores, and Tegner activity levels were compared. The arthroscopy findings were evaluated at a mean postoperative time of 6.7 ± 2.9 months. Results: The mean Lysholm score improved significantly from 69.3 ± 16.3 points preoperatively to 95.4 ± 3.6 points postoperatively ( P < .005). The mean IKDC subjective score also improved significantly from 26.5% ± 19.0% preoperatively to 87.8% ± 7.5% postoperatively ( P < .001). The Tegner activity level recovered to the preinjury level in 6 patients and to 1 level below the preinjury level in 4 patients. The follow-up arthroscopies showed complete healing in 7 patients (70%) and incomplete healing in 3 patients (30%). Conclusion: Meniscal repair of degenerative horizontal cleavage tears using fibrin clots resulted in improved Lysholm and IKDC subjective scores, but the complete healing rate on follow-up arthroscopy was only 70%. Clinical Relevance: If we are to prevent osteoarthritis, we should minimize resection and restore the contact area of the meniscus to preserve the original shape.
Glenoid Rim Anatomy
Authors: Levy Yadin D. , Williamson Michael , Flores-Hernandez Cesar , D’Lima Darryl D. , Hoenecke Heinz R. 
Published: November 2014

Background: Injuries to the glenoid labrum frequently require repair with anchors. Placing anchor devices arthroscopically can be challenging, and anchor malpositioning can complicate surgical outcomes. Purpose: To determine the safe insertion range and optimal insertion angle of glenoid labral anchors at various positions on the glenoid rim and to establish surgical guidelines that minimize risk of anchor perforation. Study Design: Descriptive laboratory study. Methods: Three-dimensional computed tomography scans of 30 normal cadaveric specimens were obtained. A virtual model of a generic labral anchor was inserted into the rim of the glenoid at the clockface positions represented by 12:00, 1:30, 3:00, 4:30, 6:00, 7:30, 9:00, and 10:30. At each position, the safe insertion range was the maximal range measured, and the optimal insertion angle was identified as the angle between the bisector of the safe insertion range and the glenoid face. Results: Progressing in the clockwise direction, beginning at the 12:00 position, the safe insertion ranges (mean ± SD ) were 55.9° ± 10.6°, 63.6° ± 17.6°, 47.7° ± 9.1°, 46.1° ± 8°, 73.9° ± 9.7°, 40.9° ± 6.5°, 40.4° ± 7.4°, and 39.9° ± 7.1°, respectively. The optimal insertion angles were 47.9° ± 7.6°, 53.1° ± 10.9°, 35.0° ± 4.4°, 42.4° ± 4.9°, 60.9° ± 8.4°, 36.6° ± 5.9°, 31.2° ± 4.9°, 34.8° ± 4.6°, respectively. Conclusion: Optimal insertion angles and safe insertion ranges varied significantly with respect to the position on the glenoid face. The safe insertion range and optimal insertion angle were found to be wider at the anterior glenoid as compared with the posterior glenoid. A posterolateral insertion angle was safer than an anterior insertion angle at the 10:30 position. Clinical Relevance: Proper arthroscopic technique resulting in anchor insertion at the correct angle, depth, and location will prevent anchor-related glenohumeral complications such as glenoid perforation, cartilage damage, persistent pain, decreased range of motion, and failure of the reconstruction.
Free breathing myocardial perfusion data sets for performance analysis of motion compensation algorithmss
Authors: Wollny Gert , Kellman Peter 
Published: November 2014

Abstract

Background
Perfusion quantification by using first-pass gadolinium-enhanced myocardial perfusion magnetic resonance imaging (MRI) has proved to be a reliable tool for the diagnosis of coronary artery disease that leads to reduced blood flow to the myocardium. The image series resulting from such acquisition usually exhibits a breathing motion that needs to be compensated for if a further automatic analysis of the perfusion is to be executed. Various algorithms have been presented to facilitate such a motion compensation, but the lack of publicly available data sets hinders a proper, reproducible comparison of these algorithms.

Material
Free breathing perfusion MRI series of ten patients considered clinically to have a stress perfusion defect were acquired; for each patient a rest and a stress study was executed. Manual segmentations of the left ventricle myocardium and the right-left ventricle insertion point are provided for all images in order to make a unified validation of the motion compensation algorithms and the perfusion analysis possible. In addition, all the scripts and the software required to run the experiments are provided alongside the data, and to enable interested parties to directly run the experiments themselves, the test bed is also provided as a virtual hard disk.

Findings
To illustrate the utility of the data set two motion compensation algorithms with publicly available implementations were applied to the data and earlier reported results about the performance of these algorithms could be confirmed.

Conclusion
The data repository alongside the evaluation test bed provides the option to reliably compare motion compensation algorithms for myocardial perfusion MRI. In addition, we encourage that researchers add their own annotations to the data set, either to provide inter-observer comparisons of segmentations, or to make other applications possible, for example, the validation of segmentation algorithms.
Sensing the room: an integrated implementation process to visualize indoor temperature data on floor plans
Authors: Shin Minkyu , Lee Sang-ik , Lee Hyunsoo , Lee Jin-Kook 
Published: November 2014

Abstract

Background
Recently multi-use environmental sensors became affordable and easy to control. This improvement enabled us to measure the broad range of indoor environments by using low-priced and controllable sensor devices. As the data set acquired by widely installed environmental sensors increased significantly, the need for making effective use of the data has become of importance. We developed an integrated visualization mechanism to express larger amounts of sensor data.

Method
The mechanism for visualization on floor plan described in this paper consists of the following modules: 1) the sensor module; 2) the data collection module; 3) the data processing module; 4) the spatial data module; 5) the sensor location module; and 6) the data visualization module. A demonstration following the mechanism is introduced in this paper for evaluating the integrated visualization approach. We set up a test-purposed and versatile toolkit that is cheaper, smaller and more controllable than conventional tools. We collect indoor environmental data set composed of sequential numeric data so as to use them as parameters for visualization. We inspected three major issues in the process: 1) indoor temperature data of a specific room collected at a second interval; 2) such a data set can be varied by subdivided spots of interest using multiple toolkits; 3) as a result, the collection of data is regarded as one type of parameter for visualization on top of the room's floor plan, e.g. a sudden change of sequential numbers.

Results
Indoor environment such as temperature changes are shown as colors overlapped on the floor plan. In this way it may be easier to understand the state of indoor environment and factors which influence the environment. The floor plan based visualization of an indoor environmental element seems intuitive compared to just listing the numeric information.

Conclusion
This paper introduces and demonstrates an integrated approach for visualizing the indoor environment on a floor plan with an actual test case. Combined with the building model, the visualized data can be used for recognition of the factors affecting to the target environmental element. We expect floor plan-based visualization to be used for decision-making.
Programming the group behaviors of bacterial communities with synthetic cellular communication
Authors: Kong Wentao , Celik Venhar , Liao Chen , Hua Qiang , Lu Ting 
Published: November 2014

Abstract
Synthetic biology is a newly emerged research discipline that focuses on the engineering of novel cellular behaviors and functionalities through the creation of artificial gene circuits. One important class of synthetic circuits currently under active development concerns the programming of bacterial cellular communication and collective population-scale behaviors. Because of the ubiquity of cell-cell interactions within bacterial communities, having an ability of engineering these circuits is vital to programming robust cellular behaviors. Here, we highlight recent advances in communication-based synthetic gene circuits by first discussing natural communication systems and then surveying various functional engineered circuits, including those for population density control, temporal synchronization, spatial organization, and ecosystem formation. We conclude by summarizing recent advances, outlining existing challenges, and discussing potential applications and future opportunities.
Can Urinary PCA3 Supplement PSA in the Early Detection of Prostate Cancer?
Authors: Wei John T. , Feng Ziding , Partin Alan W. , Brown Elissa , Thompson Ian , Sokoll Lori , Chan Daniel W. , Lotan Yair , Kibel Adam S. , Busby J. Erik , Bidair Mohamed , Lin Daniel W. , Taneja Samir S. , Viterbo Rosalia , Joon Aron Y. , Dahlgren Jackie , Kagan Jacob , Srivastava Sudhir , Sanda Martin G. 
Published: November 2014

Purpose Given the limited sensitivity and specificity of prostate-specific antigen (PSA), its widespread use as a screening tool has raised concerns for the overdiagnosis of low-risk and the underdiagnosis of high-grade prostate cancer. To improve early-detection biopsy decisions, the National Cancer Institute conducted a prospective validation trial to assess the diagnostic performance of the prostate cancer antigen 3 (PCA3) urinary assay for the detection of prostate cancer among men screened with PSA. Patients and Methods In all, 859 men (mean age, 62 years) from 11 centers scheduled for a diagnostic prostate biopsy between December 2009 and June 2011 were enrolled. The primary outcomes were to assess whether PCA3 could improve the positive predictive value (PPV) for an initial biopsy (at a score > 60) and the negative predictive value (NPV) for a repeat biopsy (at a score < 20). Results For the detection of any cancer, PPV was 80% (95% CI, 72% to 86%) in the initial biopsy group, and NPV was 88% (95% CI, 81% to 93%) in the repeat biopsy group. The addition of PCA3 to individual risk estimation models (which included age, race/ethnicity, prior biopsy, PSA, and digital rectal examination) improved the stratification of cancer and of high-grade cancer. Conclusion These data independently support the role of PCA3 in reducing the burden of prostate biopsies among men undergoing a repeat prostate biopsy. For biopsy-naive patients, a high PCA3 score (> 60) significantly increases the probability that an initial prostate biopsy will identify cancer.
Phase II Trial of the Anti-CD19 Bispecific T Cell–Engager Blinatumomab Shows Hematologic and Molecular Remissions in Patients With Relapsed or Refractory B-Precursor Acute Lymphoblastic Leukemia
Authors: Topp Max S. , Gökbuget Nicola , Zugmaier Gerhard , Klappers Petra , Stelljes Matthias , Neumann Svenja , Viardot Andreas , Marks Reinhard , Diedrich Helmut , Faul Christoph , Reichle Albrecht , Horst Heinz-August , Brüggemann Monika , Wessiepe Dorothea , Holland Chris , Alekar Shilpa , Mergen Noemi , Einsele Hermann , Hoelzer Dieter , Bargou Ralf C. 
Published: November 2014

Purpose Patients with relapsed or refractory acute lymphoblastic leukemia (ALL) have a dismal prognosis. CD19 is homogenously expressed in B-precursor ALL and can be targeted by the investigational bispecific T cell–engager antibody blinatumomab. A phase II trial was performed to determine clinical activity in this patient cohort. Patients and Methods Thirty-six patients with relapsed or refractory B-precursor ALL were treated with blinatumomab in cycles of 4-week continuous infusion followed by a 2-week treatment-free interval in a single-arm study with a dose-finding stage and an extension stage. The primary end point was complete remission (CR) or CR with partial hematologic recovery (CRh). Major secondary end points included minimal residual disease (MRD) response, rate of allogeneic hematopoietic stem-cell transplantation (HSCT) realization, relapse-free survival (RFS), overall survival (OS), and incidence of adverse events (AEs). Results Median age was 32 years (range, 18 to 77 years). Twenty-five patients (69%) achieved a CR or CRh, with 88% of the responders achieving an MRD response. Median OS was 9.8 months (95% CI, 8.5 to 14.9), and median RFS was 7.6 months (95% CI, 4.5 to 9.5). Thirteen responders (52%) underwent HSCT after achieving a CR or CRh. The most frequent AE during treatment was pyrexia (grade 1 or 2, 75%; grade 3, 6%). In six patients with nervous system or psychiatric disorder AEs and in two patients with cytokine release syndrome, treatment had to be interrupted or discontinued. These medical events were resolved clinically. Conclusion The data support further investigation of blinatumomab for the treatment of adult patients with relapsed or refractory ALL in a larger confirmatory study.