bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengolompokan Data Tingkat Partisipasi Masyarakat dalam Penanggulanagan HIV/AIDS Menggunakan K-Means Berbasis Median dalam Penentuan Pusat Klaster
Authors: Sulton Rizal 
Published: August 2024

Pada tahun 2016, di Indonesia kasus baru infeksi HIV meningkat 33,4% dibandingkan tahun sebelumnya. Terdapat 69,3% kasus baru infeksi HIV pada kelompok umur 25-49, sementara 63,3% penderita adalah laki-laki. Rasio HIV/AIDS antara laki-laki dan perempuan tercatat pada kisaran 2:1. Salah satu layanan penanggulangan HIV-AIDS dan IMS ialah konseling dan tes HIV (KT HIV). Berdasarkan berlimpahnya data konseling dan tes, informasi yang tersembunyi dapat diketahui dengan cara melakukan pengolahan terhadap data tersebut sehingga berguna bagi petugas kesehatan. Pengolahan data klien perlu dilakukan untuk mengetahui informasi penting berupa pengetahuan baru (knowledge discovery) yakni berupa pengelompokan data atau klaster data tingkat partisipasi masyarakat dalam penanggulangan HIV AIDS . Metode yang digunakan dalam pengolahan data di penelitian ini adalah K-Means dengan berbasis perhitungan median dalam penentuan pusat klaster, penggunaan median adalah untuk meningkatkan kinerja K-means dalam penentuan pusat klaster sehinggna memperoleh hasil data pengelompokan lebih baik. Hasil penelitian menunjukkan bahwa proses klaster K-Means yang menggunakan penentuan pusat klaster berbasis median menghasilkan nilai evaluasi DBI 0,5857 sedangkan proses klaster K-Means tanpa penentuan pusat klaster berbasis median bernilai evaluasi DBI -0,647. Menurut teori konsep DBI, DBI tersebut menginginkan nilai (non-negatif >=0) sekecil mungkin untuk menilai baiknya klaster yang didapat. Dengan demikian berdasarkan hasil evaluasi DBI pada proses K-means menggunakan penentuan pusat klaster awal berbasis median lebih baik dari pada proses perhitungan K-Means tanpa menggunakan penentuan awal klaster berbasis median
Sistem Informasi Survei Kepuasan Pengunjung Perpustakaan Ibrahimy Menggunakan Framework Codeigniter 3 dan MySQL
Authors: Arifin Bustanul 
Published: August 2024

Perpustakaan Universitas Ibrahimy Sukorejo merupakan bagian dari Perpustakaan Pondok Pesantren Salafiyah Syafi’iyah Sukorejo yang lebih dikenal dengan Perpustakaan Ibrahimy. Perpustakaan merupakan salah satu pusat informasi yang mempunyai peranan penting dalam proses penyebaran informasi, menemukan dan mengembangkan informasi atau lembaga pendidikan serta alat pendidikan untuk mengatur proses jalannya pendidikan. Salah satu upaya yang dilakukan dalam rangka memperbaiki layanan dan termasuk dalam pengembangan sistem yang telah dirancang adalah melakukan survei kepuasan terhadap layanan perpustakaan. Pada saat ini prosedur penilaian survei kepuasan pengunjung masih dalam tahap tulis menulis yaitu membagikan sebuah angket kepada seluruh pengunjung sehingga sengat membutuhkan waktu yang begitu lama dalam proses penilaian dan sangat mudah terjadi kerusakan pada hasil penilaian yang terbuat dari kertas. Dari pemaparan diatas, peniliti memiliki solusi pada pengambilan titik fokus pada sistem informasi survei kepuasan pengunjung sebagai alat bantu dalam proses penilaian kepuasan pengunjung terhadap layanan perpustakaan. Selain itu proses penilaian kepuasan pengunjung juga dapat mengukur tingkat kepuasan pengunjung terhadap Perpustakaan Universitas Ibrahimy serta memberikan peningkatan terhadap kemajuan kualitas Perpustakaan ibrahimy. Dalam penelitian ini telah dihasilkan sistem informasi survei kepuasan pengunjung perpustakaan ibrahimy menggunakan framework codeigniter 3 dan mysql sebagai proses dalam meningkatkan kualitas pelayanan perpustakaan dan mempermudah dalam proses penilaian kepuasan secara akurat.
PERKAWINAN DI BAWAH UMUR MASYARAKAT 5.0 PERSPEKTIF FIQH MADZHAB SYAFI’I DAN UNDANG UNDANG PERKAWINAN DI INDONESIA
Authors: Alindi Rizki Kila , Al Amin Habibi 
Published: August 2024

ABSTRACTLegal marriage is an absolute stipulation according to Islam. However, these noble intentions are often not in line with expectations if the husband and wife do not yet have maturity both physically and mentally. This unpreparedness can occur if it is caused by the intensity of children using gadgets in the 5.0 era. This journal will examine how the law of underage marriage in the community 5.0 is from the perspective of the Syafi'i madhhab fiqh, and how the relevance of the Syafi'i fiqh legal reasoning to the Marriage Law in Indonesia for underage marriages in the 5.0 community. The conclusion in this study is that the marriage law under the age of 5.0 according to the Syafi'i school is valid. By looking at the element of ability, namely prioritizing maslahah. The legal relevance of marriage under the age of 5.0 in the perspective of the Imam Syafi'i madhhab and the Marriage Law is the age limit. Where both clearly regulate the age limit for marriage. This correlation can be used for the concept of underage marriage in the community 5.0 and all deviations in it.Keywords: Underage Marriage, Shafi'i Madzhab Fiqh, Marriage Law. ABSTRAKPerkawinan yang sah merupakan ketetapan mutlak menurut agama Islam. Akan tetapi, niat mulia tersebut seringkali tidak sesuai dengan harapan apabila diantara pasangan suami isteri belum memiliki kedewasaan baik secara fisik maupun mental. Ketidaksiapan tersebut bisa terjadi apabila disebabkan oleh intensitas anak-anak menggunakan gadget di era 5.0. Artikel ini akan mengkaji bagaimana hukum perkawinan di bawah umur masyarakat 5.0 perspektif fiqh madzhab Syafi’i, serta bagaimana relevansi nalar hukum fiqh madzhab Syafi’i terhadap Undang Undang Perkawinan di Indonesia terhadap perkawinan di bawah umur masyarakat 5.0. Kesimpulan dalam penelitian ini yakni hukum perkawinan di bawah umur masyarakat 5.0 menurut madzhab Syafi’i adalah sah. Dengan melihat unsur kebolehan tersebut yakni mengutamakan maslahah. Relevansi hukum perkawinan di bawah umur masyarakat 5.0 dalam persepektif madzhab imam Syafi’i dan Undang Undang Perkawinan adalah pada batasan usia. Dimana keduanya mengatur secara jelas aturan batasan usia perkawinan. Korelasi tersebut dapat digunakan untuk konsep perkawinan di bawah umur masyarakat 5.0 dan segala penyimpangan di dalamnya.Kata Kunci: Perkawinan di Bawah Umur, Fiqh Madzhab Syafi’i, Undang --undang Perkawinan.
Menakar Potensi Sosiologi Hukum sebagai Pendekatan Perdamaian: Pembacaan dari Perspektif Strukturasi Giddens
Authors: Harnadi Dodik 
Published: August 2024

Positivistic legal approach still become dominant paradigm in the process of law enforcement. The dominance of the paradigm is also seen in the conflict resolution and peacebuilding process. Positive law is considered as the most effective instrument in overcoming conflict and tension. Unfortunately, its repressive nature making this approach also full of criticism.Such as its disregard of for the local norms as the living laws in society. This study of sociology of law as an approach in the peace process is aimed to fill the gap. Compared to the positivistic paradigm, the sociology of law is lack of popularity. The level of jurist acceptance of the sociology of law was also same. Along with the many criticism of the positivistic paradigm as it often gave rise to the gap between ideality of positive law and living law, the popularity of sociology of law also began to rise. However, in the sense of peacebuilding, the sociological approach of law remains a novelty. This literature study analysed conceptually on how the sociology of law is applied to the local based peacebuilding. The strong emphasis on the local habit and norm as living law become a meeting point between the sociology of law and local based peacebuilding. In addition, to explain how local individuals act as an empowered agent in accordance with living law, this study utilized Giddens' theory of Structuration.Keywords: Living law, Peacebuilding, Local, Agent.
Pengelolaan Penerimaan Peserta Didik Baru (PPDB) Ditinjau Dari Perspektif Total Quality Management (TQM) di Madrasah Bertaraf Internasional (MBI) Amanatul Ummah Pacet Mojokerto
Authors: Al Qorony Wais , Mujiono  
Published: August 2024

Abstract— Educational institutions prioritize quality. With the emergence of competing schools, it becomes very important to identify schools that meet quality standards. The TQM integrated quality control system combines the efforts of developing, maintaining, and improving quality from all levels in an organizational group to increase productivity levels. To become a learner at an educational institution (madrasah), there must be registration of new learners, first a search process is carried out, then a recruitment process is carried out to identify prospective new learners and capture these prospective learners. The purpose of this research has been adjusted to the focus of the research, so that it is an effort to provide a comprehensive explanation and description: 1) To analyze the selection process of new student admissions at MBI Amanatul Ummah. 2) To analyze the implications of the selection process of new student admissions at MBI Amanatul Ummah. This research is a field study with a qualitative approach applied. In this study, various data collection techniques were used by researchers through the Observation method, Interview Method, Documentation Method. The results showed the results that 1) PPDb program planning at MBI Amanatul Ummah in its implementation, MBI leaders wait for direction from the foundation. 2) The PPDb committee is taken from the Functionalists, TU Staff, and Head of Class. The information media used are social media and the school website. 3) The tests tested in the written test path are academic potential tests and psychological tests. The achievement path is opened only for those who have a minimum certificate of district level champion, the test tested is an interview related to the certificate attached.
Key Words: Total Quality Management, New Student Registration
Synergistic in vitro activity and mechanism of KBN lotion and miconazole nitrate against drug-resistant Candida albicans biofilms
Authors: Cao Xiaoyu , Xiao Ni , Huang Jingyi , Li Li , Zhong Lian , Zhang Jun , Wang Fengyun 
Published: August 2024

BackgroundIn the face of increasing antifungal resistance among Candida albicans biofilms, this study explores the efficacy of a combined treatment using Kangbainian lotion (KBN) and miconazole nitrate (MN) to address this challenge.MethodsUsing UPLC-Q-TOF/MS Analysis for Identification of Active Compounds in KBN Lotion; FICI for synergy evaluation, XTT and ROS assays for biofilm viability and oxidative stress, fluorescence and confocal laser scanning microscopy (CLSM) for structural and viability analysis, and real-time fluorescence for gene expression.ConclusionOur study indicates that the combined application of KBN and MN somewhat impacts the structural integrity of Candida albicans biofilms and affects the expression of several key genes involved in biofilm formation, including ALS1, ALS3, HWP1, HSP90, and CSH1. These preliminary findings suggest that there may be a synergistic effect between KBN and MN, potentially influencing not only the structural aspects of fungal biofilms but also involving the modulation of genetic pathways during their formation.
Age-specific performance of human papillomavirus E6/E7 mRNA assay versus cytology for primary cervical cancer screening and triage: community-based screening in China
Authors: Zhang Jing , Liu Guangcong , Yang Di , Cui Xiaoli , Wang Chunyan , Wang Danbo , Piao Haozhe 
Published: August 2024

BackgroundIn the general population, primary human papillomavirus (HPV) testing is advocated for cervical cancer (CC) screening. HPV E6/E7 mRNA (Aptima HPV, AHPV) assays have garnered considerable traction due to their higher specificity when compared with HPV DNA assays. Here, we investigated age-specific primary AHPV screening assays and different triage strategies versus cytology to identify the best approach.MethodsBetween April 2018 and December 2021, we recruited female participants from 34 communities across Liaoning province and Qingdao City, China. Primary cervical screening protocols included liquid-based cytology (LBC) and AHPV assays, with females positive for any assays undergoing colposcopy. Genotyping (AHPV-GT) was conducted on all HPV-positive samples. Our primary outcomes were the identification of age-specific detection rates, colposcopy referral rates, and sensitivity and specificity values for high-grade squamous intraepithelial lesions or worse (HSIL+). AHPV and different triage strategy performances were also examined across different age cohorts.ResultsOur investigation included 9911 eligible females. Age-specific abnormal cytology rates were in the 6.1%–8.0% range, and were highest in 45–54-year olds. When compared with 35–44-or 45–54-year olds, HPV prevalence was highest in 55–64-year olds (12.2% or 11.6% vs.14.1%, P = 0.048 and P = 0.002, respectively). In 35–44-year olds, AHPV sensitivity for detecting HSIL+ was 96.6 (95% confidence interval [CI]: 89.7–100) - significantly higher than LBC sensitivity (65.5 [95% CI: 48.3–82.8], P &lt; 0.001). When compared with LBC, HSIL+ detection rates by AHPV-GT using reflex LBC triage increased by 31.5% (9.6‰ vs. 7.3‰), and colposcopy referral rates decreased by 16.4% (5.1% vs. 6.1%). In 45–54-year olds, HSIL+ detection rates for AHPV-GT using reflex LBC triage were lower than LBC rates (6.2‰ vs. 6.6‰). In 55–64-year olds, AHPV sensitivity (97.2 [95% CI: 91.7–100.0]) was higher than LBC sensitivity (66.7 [95% CI: 50.0–80.6], P = 0.003). The area under the curve (AUC) value was not significantly different between AHPV-GT with reflex LBC triage and LBC (0.845 [95% CI: 0.771–0.920] vs. 0.812 [95% CI: 0.734–0.891], P = 0.236).ConclusionsPrimary AHPV screening using different triage strategies were different across different age cohorts. Thus, AHPV may be an appropriate primary screening method for 35–44 and 55–64 year old females, while AHPV-GT with reflex LBC triage may be more apt for 35–44 year old females.
Exploring the shared biomarkers between cardioembolic stroke and atrial fibrillation by WGCNA and machine learning
Authors: Zhang Jingxin , Zhang Bingbing , Li Tengteng , Li Yibo , Zhu Qi , Wang Xiting , Lu Tao 
Published: August 2024

BackgroundCardioembolic Stroke (CS) and Atrial Fibrillation (AF) are prevalent diseases that significantly impact the quality of life and impose considerable financial burdens on society. Despite increasing evidence of a significant association between the two diseases, their complex interactions remain inadequately understood. We conducted bioinformatics analysis and employed machine learning techniques to investigate potential shared biomarkers between CS and AF.MethodsWe retrieved the CS and AF datasets from the Gene Expression Omnibus (GEO) database and applied Weighted Gene Co-Expression Network Analysis (WGCNA) to develop co-expression networks aimed at identifying pivotal modules. Next, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis on the shared genes within the modules related to CS and AF. The STRING database was used to build a protein-protein interaction (PPI) network, facilitating the discovery of hub genes within the network. Finally, several common used machine learning approaches were applied to construct the clinical predictive model of CS and AF. ROC curve analysis to evaluate the diagnostic value of the identified biomarkers for AF and CS.ResultsFunctional enrichment analysis indicated that pathways intrinsic to the immune response may be significantly involved in CS and AF. PPI network analysis identified a potential association of 4 key genes with both CS and AF, specifically PIK3R1, ITGAM, FOS, and TLR4.ConclusionIn our study, we utilized WGCNA, PPI network analysis, and machine learning to identify four hub genes significantly associated with CS and AF. Functional annotation outcomes revealed that inherent pathways related to the immune response connected to the recognized genes might could pave the way for further research on the etiological mechanisms and therapeutic targets for CS and AF.
Risk prediction model for in-stent restenosis following PCI: a systematic review
Authors: Xiang Qin , Xiong Xiao-Yun , Liu Si , Zhang Mei-Jun , Li Ying-Jie , Wang Hui-Wen , Wu Rui , Chen Lu 
Published: August 2024

IntroductionThe morbidity and mortality rates of coronary heart disease are significant, with PCI being the primary treatment. The high incidence of ISR following PCI poses a challenge to its effectiveness. Currently, there are numerous studies on ISR risk prediction models after PCI, but the quality varies and there is still a lack of systematic evaluation and analysis.MethodsTo systematically retrieve and evaluate the risk prediction models for ISR after PCI. A comprehensive search was conducted across 9 databases from inception to March 1, 2024. The screening of literature and extraction of data were independently carried out by two investigators, utilizing the checklist for critical appraisal and data extraction for systematic reviews of prediction modeling studies (CHARMS). Additionally, the risk of bias and applicability were evaluated using the Prediction Model Risk of Bias Assessment Tool (PROBAST).ResultsA total of 17 studies with 29 models were included, with a sample size of 175–10,004 cases, and the incidence of outcome events was 5.79%–58.86%. The area under the receiver operating characteristic curve was 0.530–0.953. The top 5 predictors with high frequency were diabetes, number of diseased vessels, age, LDL-C and stent diameter. Bias risk assessment into the research of the risk of higher bias the applicability of the four study better.DiscussionThe overall risk of bias in the current ISR risk prediction model post-PCI is deemed high. Moving forward, it is imperative to enhance study design and specify the reporting process, optimize and validate the model, and enhance its performance.
Epicardial pulsed-field ablation-impact of electric field and heat distribution induced by coronary metallic stents
Authors: Wang Zhen , Liang Ming , Sun Jingyang , Zhang Jie , Li Yunhao , Xu Lisheng , Han Yaling 
Published: August 2024

BackgroundPulsed-field ablation (PFA) technique is a nonthermal ablation technique. No study has yet evaluated the effect of the positional relationship between the ablation electrode (AE) and the coronary metal stent (CMS) on the electric field distribution and temperature distribution in epicardial ablation. Our study aimed to evaluate the effect of the CMS on the electric field as well as the temperature distribution in different models.MethodsMulti-angle modeling of the CMS and AE was performed. The PFA ablation region was evaluated with a field strength contour of 1,000 V/cm, which was used to assess the validity of the two-dimensional (2D) model simulation data as well as the distribution of the multi-angle electric field and temperature in the three-dimensional (3D) model.ResultsThe presence of the CMS had little effect on the width of the ablation area (0.2 mm). In the 3D model, the temperature of the ablation area was highest when the angle between the AE and the CMS was in the 90° position (43.4°C, 41.3°C); a change in the distance between the AE and the CMS affected the temperature of the ablation area (maximum 2.1°C) and the width of the ablation (maximum 0.32 mm).ConclusionThe presence of the CMS distorts the distribution of the electric field, but does not produce a change in the extent of the ablation damage, nor does it bring thermal damage to the ablation region. Different simulation models give similar results in PFA calculations, and this study effectively reduces the complexity of modeling simulation.
Radiomics-based machine learning model to phenotype hip involvement in ankylosing spondylitis: a pilot study
Authors: Hu Zhengyuan , Wang Yan , Ji Xiaojian , Xu Bo , Li Yan , Zhang Jie , Liu Xingkang , Li Kunpeng , Zhang Jianglin , Zhu Jian , Lou Xin , Huang Feng 
Published: August 2024

ObjectivesHip involvement is an important reason of disability in patients with ankylosing spondylitis (AS). Unveiling the potential phenotype of hip involvement in AS remains an unmet need to understand its biological mechanisms and improve clinical decision-making. Radiomics, a promising quantitative image analysis method that had been successfully used to describe the phenotype of a wide variety of diseases, while it was less reported in AS. The objective of this study was to investigate the feasibility of radiomics-based approach to profile hip involvement in AS.MethodsA total of 167 patients with AS was included. Radiomic features were extracted from pelvis MRI after image preprocessing and feature engineering. Then, we performed unsupervised machine learning method to derive radiomics-based phenotypes. The validation and interpretation of derived phenotypes were conducted from the perspectives of clinical backgrounds and MRI characteristics. The association between derived phenotypes and radiographic outcomes was evaluated by multivariable analysis.Results1321 robust radiomic features were extracted and four biologically distinct phenotypes were derived. According to patient clinical backgrounds, phenotype I (38, 22.8%) and II (34, 20.4%) were labelled as high-risk while phenotype III (24, 14.4%) and IV (71, 42.5%) were at low risk for hip involvement. Consistently, the high-risk phenotypes were associated with higher prevalence of MRI-detected lesion than the low-risk. Moreover, phenotype I had significant acute inflammation signs than phenotype II, while phenotype IV was enthesitis-predominant. Importantly, the derived phenotypes were highly predictive of radiographic outcomes of patients, as the high-risk phenotypes were 3 times more likely to have radiological hip lesion than the low-risk [27 (58.7%) vs 16 (28.6%); adjusted odds ratio (OR) 2.95 (95% CI 1.10, 7.92)].ConclusionWe confirmed for the first time, the clinical actionability of profiling hip involvement in AS by radiomics method. Four distinct phenotypes of hip involvement in AS were identified and importantly, the high-risk phenotypes could predict structural damage of hip involvement in AS.