bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contemporary survival in metastatic bladder cancer patients: A population‐based study
Authors: Di Bello Francesco , Siech Carolin , Jannello Letizia Maria Ippolita , de Angelis Mario , Rodriguez Peñaranda Natali , Tian Zhe , Goyal Jordan A. , Baudo Andrea , Collà Ruvolo Claudia , Califano Gianluigi , Creta Massimiliano , Saad Fred , Shariat Shahrokh F. , Acquati Pietro , de Cobelli Ottavio , Briganti Alberto , Chun Felix K. H. , Micali Salvatore , Longo Nicola , Karakiewicz Pierre I. 
Published: July 2024

AbstractThe overall survival (OS) improvement after the advent of several novel systemic therapies, designed for treatment of metastatic urothelial carcinoma of the urinary bladder (mUCUB), is not conclusively studied in either contemporary UCUB patients and/or non‐UCUB patients. Within the Surveillance, Epidemiology, and End Results database, contemporary (2017–2020) and historical (2000–2016) systemic therapy‐exposed metastatic UCUB and, subsequently, non‐UCUB patients were identified. Separate Kaplan–Meier and multivariable Cox regression (CRM) analyses first addressed OS in mUCUB and, subsequently, in metastatic non‐UCUB (mn‐UCUB). Of 3443 systemic therapy‐exposed patients, 2725 (79%) harbored mUCUB versus 709 (21%) harbored mn‐UCUB. Of 2725 mUCUB patients, 582 (21%) were contemporary (2017–2020) versus 2143 (79%) were historical (2000–2016). In mUCUB, median OS was 11 months in contemporary versus 8 months in historical patients (Δ = 3 months; p < .0001). After multivariable CRM, contemporary membership status (2017–2020) independently predicted lower overall mortality (OM; hazard ratio [HR] = 0.68, 95% confidence interval [CI] = 0.60–0.76; p < .001). Of 709 mn‐UCUB patients, 167 (24%) were contemporary (2017–2020) and 542 (76%) were historical (2000–2016). In mn‐UCUB, median OS was 8 months in contemporary versus 7 months in historical patients (Δ = 1 month; p = .034). After multivariable CRM, contemporary membership status (2017–2020) was associated with HR of 0.81 (95% CI = 0.66–1.01; p = .06). In conclusion, contemporary systemic therapy‐exposed metastatic patients exhibited better OS in UCUB. However, the magnitude of survival benefit was threefold higher in mUCUB and approximated the survival benefits recorded in prospective randomized trials of novel systemic therapies.
Rheumatoid neutrophilic dermatitis
Authors: Scotti Biagio , Misciali Cosimo , Merli Yuri , Bardazzi Federico , Abbenante Diego , Dika Emi , Piraccini Bianca M. 
Published: July 2024

AbstractRheumatoid neutrophilic dermatitis (RND) is a dermatological condition typically associated with rheumatoid arthritis (RA). The low prevalence of RND and the wide spectrum of its possible clinical appearances make the diagnosis challenging. Current literature is still lacking a comprehensive overview of this rare cutaneous disorder. The aim of this review is to summarize data from the existing literature on RND, focusing on its epidemiology, clinical manifestations, histopathology and treatment. Hence, a comprehensive literature search of case reports and series was made, starting from a Medline (via PubMed) and Scopus databases. We also included in the analysis one patient attending to our dermatology department and diagnosed with RND. Overall, 54 cases of RND were identified. The majority of patients were female (72.3%) with a median (IQR) age at the time of diagnosis of 58 (65‐45) years. RND followed the onset of RA in 87% of patients with an average (SD) latency time of approximately 10 (8.9) years. In 1 (1.8%) case the dermatitis preceded the appearance of joint symptoms, while in three (5.5%) cases it occurred concomitantly with them. Seropositive RA was the major associated form (76.5%). Clinically, asymptomatic papules (31%), nodules (15.1%) and/or plaques (13.5%) distributed bilaterally on extremities were most frequently described. Notably, females were more prone to develop a painful dermatitis (84.6%) compared to males. The vesicobullous (12.7%) and pustular (9.2%) clinical subtypes were the most demonstrative in contrast to the urticarial skin manifestations and the potential figurative/annular distribution of the lesions. Spontaneous resolution of RND was rare (5.5%). Systemic treatments, mainly represented by steroids and anti‐neutrophilic agents (dapsone, colchicine), were consistently required.
Effect of agitation speed on methylene blue discoloration kinetics via ambient air cold plasma
Authors: Pereira Alessandra Mbroczkoski , Khalaf Péricles Inácio 
Published: July 2024

AbstractThis research investigates the kinetics of methylene blue (MB) discoloration using ambient air cold plasma, with a focus on the impact of agitation speed (100 and 750 rpm). The study revealed pseudo‐first‐order kinetics for MB discoloration, pinpointing optimal conditions at 35.00°C and 100 rpm. These parameters minimized half‐life times, correlated with observed kobs values. A decreasing pH trend, more pronounced at 750 rpm, was attributed to increased acidic nitrogen species (HNO3 and HNO2) production, adversely affecting dye discoloration. Concurrently, enhanced electrolyte concentration was noted from rising conductivity due to plasma production of reactive species followed by solubilization in the aqueous phase. The calculated thermodynamic activation parameters comprised: Ea = 7.96 kJ mol−1, ΔH‡ = +5.53 kJ mol−1, ΔS‡ = −253.23 J K−1 mol−1, and ΔG‡ = +79.77 kJ mol−1 (100 rpm); and Ea = 12.94 kJ mol−1, ΔH‡ = +13.78 kJ mol−1, ΔS‡ = −239.06 J K−1 mol−1, and ΔG‡ = +80.58 kJ mol−1, (750 rpm). The lowest Ea and ΔG‡ values at 100 rpm reinforced lower agitation favoring the reaction. The study demonstrated a linear decay of the reaction rate constant with the square root of ionic strength. This result, besides the negative activation entropy and moderate activation enthalpy led to a proposition to the determinant step for the transition state formation, involving an associative step between a solvated electron and the protonated substrate. The optimal dye discoloration rate and energy yield were observed at 35.00°C and 100 rpm, with values of 97.2% and 3.371 × 10−2 g kW−1 h−1, respectively.
Tympanostomy Tubes Under Local Versus General Anesthesia for Children: A Prospective Long‐Term Study
Authors: Bellavance Samuel , Khoury Michel , Fournier Isabelle , Costisella Jérôme , Lapointe Annie , Giguère Chantal , Doré‐Bergeron Marie‐Joëlle , Bergeron Mathieu 
Published: July 2024

ObjectivesTympanostomy tube insertion (TTI) under local anesthesia (LA) is gaining popularity but literature comparing long‐term outcomes for children undergoing TTI under LA versus general anesthesia (GA) is limited. This study compares the long‐term quality of life (QoL) between LA and GA in children undergoing TTI. Secondary objectives included long‐term behavioral changes, parental satisfaction, tube durability, and postoperative complications.MethodsWe prospectively followed children aged under 6 who underwent TTI, under LA or GA, 2 years prior. We assessed QoL using validated scales (OM6, PedsQL), analyzed behavioral changes and parental satisfaction through qualitative scales, and retrieved data on tube durability and non‐immediate complications.ResultsA total of 84 children (LA = 42; GA = 42) had complete data and a minimum of 1 year of follow‐up. Demographic data were similar, except for younger patients in the LA group (1.4 vs. 1.9 years, p = 0.02). LA group exhibited increased fear of health care professionals following TTI (LA: Likert scale 2.1/5, GA: 1.5/5, p = 0.04). Tube retention rate was shorter in the LA group (at 15 months: GA:72%, LA:50%, p = 0.039). Two years post‐TTI, there were no differences regarding QoL (OM‐6 score; LA: 15.2/100, GA: 21.4/100, p = 0.18, and PedsQL score; LA: 84.3/100, GA: 83.8/100, p = 0.90), parental satisfaction with anesthesia (GA: 4.5/5, LA: 4.6/5, p = 0.56), and postoperative complications (GA: 3/42, LA: 7/42, p = 0.18).ConclusionsTTI under LA in children is associated with an increased fear of health care professionals and shorter functionality of tympanostomy tubes as compared to GA. No difference was observed in long‐term QoL, parental satisfaction, and complications rate.Level of Evidence3 Laryngoscope, 134:5178–5183, 2024
Targeted next‐generation sequencing reveals the genetic mechanism of Chinese Marfan syndrome cohort with ocular manifestation
Authors: Han Dongming , Wang Ziwei , Chen Xuan , Liu Zijia , Yang Zhengtao , Chen Yixi , Tian Peiyi , Li Jiankang , Wang ZhuoShi 
Published: July 2024

AbstractBackgroundMarfan syndrome (MFS) is a hereditary connective tissue disorder involving multiple systems, including ophthalmologic abnormalities. Most cases are due to heterozygous mutations in the fibrillin‐1 gene (FBN1). Other associated genes include LTBP2, MYH11, MYLK, and SLC2A10. There is significant clinical overlap between MFS and other Marfan‐like disorders.PurposeTo expand the mutation spectrum of FBN1 gene and validate the pathogenicity of Marfan‐related genes in patients with MFS and ocular manifestations.MethodsWe recruited 318 participants (195 cases, 123 controls), including 59 sporadic cases and 88 families. All patients had comprehensive ophthalmic examinations showing ocular features of MFS and met Ghent criteria. Additionally, 754 cases with other eye diseases were recruited. Panel‐based next‐generation sequencing (NGS) screened mutations in 792 genes related to inherited eye diseases.ResultsWe detected 181 mutations with an 84.7% detection rate in sporadic cases and 87.5% in familial cases. The overall detection rate was 86.4%, with FBN1 accounting for 74.8%. In cases without FBN1 mutations, 23 mutations from seven Marfan‐related genes were identified, including four pathogenic or likely pathogenic mutations in LTBP2. The 181 mutations included 165 missenses, 10 splicings, three frameshifts, and three nonsenses. FBN1 accounted for 53.0% of mutations. The most prevalent pathogenic mutation was FBN1 c.4096G>A. Additionally, 94 novel mutations were detected, with 13 de novo mutations in 14 families.ConclusionWe expanded the mutation spectrum of the FBN1 gene and provided evidence for the pathogenicity of other Marfan‐related genes. Variants in LTBP2 may contribute to the ocular manifestations in MFS, underscoring its role in phenotypic diversity.
Coupled model for electro‐osmosis consolidation and ion transport considering chemical osmosis in saturated clay soils
Authors: Ge Shangqi , Jiang Wenhao , Wang Ji‐Peng , Feng Guohui , Zheng Lingwei , Xie Xinyu 
Published: July 2024

AbstractThe electro‐osmosis approach efficiently facilitates the rapid dewatering of soil with high water content and contributes to reducing contaminant levels within the clay soil. However, the changes of chemical field caused by ion transport in the clay soil during electro‐osmosis process will also influence the clay soil consolidation effect. Existing theories predominantly tend to disregard this crucial physical process and its resultant effects, thereby restraining a comprehensive analysis of electro‐osmosis consolidation (EOC) behavior under intricate chemical conditions. This study introduces a concise model of EOC and ion transport considering chemical osmosis. The model considers the nonlinear variation of clay soil parameters such as compressibility, permeability, and effective diffusion coefficients, along with the interaction between EOC and ion transport. Meanwhile, the correctness of the model is verified from different aspects such as theoretical derivation and model comparison. Based on the proposed model, the impacts of the variation in electrical field intensity and chemical concentration on the coupled behaviors between EOC and ion transport are systematically investigated, with and without incorporating nonlinear consolidation characteristics. The results show that diffusion and electro‐migration exhibit a more pronounced effect on ion transport during EOC. Simultaneously, with the increase of ion concentration in clay soil pore solution, the effects of chemical osmosis become increasingly apparent, thereby enhancing clay soil settlement.
The turnpike property for high‐dimensional interacting agent systems in discrete time
Authors: Gugat Martin , Herty Michael , Liu Jiehong , Segala Chiara 
Published: July 2024

AbstractWe investigate the interior turnpike phenomenon for discrete‐time multi‐agent optimal control problems. While for continuous systems the turnpike property has been established, we focus here on first‐order discretizations of such systems. It is shown that the resulting time‐discrete system inherits the turnpike property with estimates of the same type as in the continuous case. In particular, we prove that the discrete time optimal control problem is strictly dissipative and the cheap control assumption holds.
Vincristine exposure in Kenyan children with cancer: CHAPATI feasibility study
Authors: Uittenboogaard Aniek , van de Velde Mirjam , van de Heijden Lisa , Mukuhi Leah , de Vries Niels , Langat Sandra , Olbara Gilbert , Huitema Alwin D. R. , Vik Terry , Kaspers Gertjan , Njuguna Festus 
Published: July 2024

AbstractThe low incidence of vincristine‐induced peripheral neuropathy (VIPN) in Kenyan children may result from low vincristine exposure. We studied vincristine exposure in Kenyan children and dose‐escalated in case of low vincristine exposure (NCT05844670). Average vincristine exposure was high. Individual vincristine exposure was assessed with a previously developed nomogram. A 20% dose increase was recommended for participants with low exposure and no VIPN, hyperbilirubinemia, or malnutrition. None of the 15 participants developed VIPN. Low vincristine exposure was seen in one participant: a dose increase was implemented without side effects. In conclusion, the participants did not develop VIPN despite having high vincristine exposure.
Wilms tumor characteristics, surgical management, outcomes, and chronic kidney disease in children with WAGR syndrome: A report from the International WAGR Syndrome Association survey
Authors: Tracy Elisabeth T. , Leraas Harold , Olson Lindsay , Shamberger Robert C. , Ehrlich Peter F. 
Published: July 2024

AbstractIntroductionChildren with WAGR (Wilms tumor, aniridia, genitourinary anomalies, and range of development delays) syndrome are predisposed to Wilms tumor (WT) and intrinsic kidney disease. Using the comprehensive International WAGR Syndrome Association (IWSA) survey of children with WAGR syndrome, we analyzed tumor characteristics, treatment and congenital risk factors, and kidney function in children with WAGR and WT.MethodsDescriptive statistics were utilized including demographics, treatment strategies, and patient outcomes. Comparisons were made between patients with WAGR and WT to those with WAGR alone. A multivariable logistic regression was completed for risk of developing WT and to identify predictors of chronic kidney disease (CKD).ResultsSixty‐four of 145 children with WAGR developed WT (44.1%). Three relapsed and one died. CKD developed in five children with WAGR without WT (5/81, 6.2%), and in 34 with WAGR and WT (34/64, 28.3%). Children with WAGR and WT were younger (p = .017), and had a greater association with CKD than WAGR children without WT (p < .0001). Two children with WT required hemodialysis, and one underwent kidney transplantation. By univariate analysis, CKD at any stage was associated with complete nephrectomy for the WT surgery (p < .0001), chemotherapy duration greater than 12 months, and three‐drug therapy. Upon multivariate analysis, prior nephrectomy was the only significant variable (p = .0002).ConclusionsEpidemiological analysis of children with WAGR demonstrated favorable oncologic outcomes, but high rate of early CKD in those who developed WT. Further study of the use of nephron‐sparing surgery in children with WAGR and strategies to delay or treat early CKD are needed.
Resilient trees for urban environments: The importance of intraspecific variation
Authors: Sjöman Henrik , Watkins Harry , Kelly Laura J. , Hirons Andrew , Kainulainen Kent , Martin Kevin W. E. , Antonelli Alexandre 
Published: July 2024

Societal Impact StatementTrees in urban environments provide us with shade, heat mitigation, flood abatement, noise and pollution reduction, pollination, beauty, and much more. However, many of these benefits are strongly connected to tree size and vitality, with larger, healthier trees providing ecosystem services more effectively, which means that selecting the right tree for site and function is crucial in order to gain all benefits from our urban trees.SummaryTrees play a major role in the Earth's biogeochemical processes, influencing soil production, hydrological, nutrient and carbon cycles, and the global climate. They store about 50% of the world's terrestrial carbon stocks, and provide habitats for a wide range of other species, supporting at least half of the Earth's known terrestrial plants and animals. Trees are not only found in forests and other natural ecosystems, but also in urban environments. Most of the human population is concentrated in cities, towns and villages, so urban trees are critical to meet on‐going and future social, economic and environmental challenges. However, many urban tree populations are strongly challenged by a changing climate, outbreaks of pests and pathogens and an urban development with increasingly dense cities and a high proportion of impermeable surface materials. The importance of intraspecific variation needs to be better acknowledged in this context, since poor matching of trees and the local climate and growing conditions can lead to extensive loss of valuable trees. By using the right genetic plant material for the challenging urban environments, a more resilient tree population with a greater diversity and higher capacity for delivering ecosystem services can be gained. Here, we wish to discuss the need to consider intraspecific variation when planning resilient tree populations for urban environments and how seed banks and botanical garden play important roles in efforts to improve the matching of genetic plant material for future environmental challenges. Strategies to enrich urban tree diversity and increase resilience are outlined.
Cover Image, Volume 92, Issue 8
Authors: Verma Jyoti , Vashisth Harish 
Published: July 2024

Front Cover: The cover image is based on the Research Article Molecular basis for differential recognition of an allosteric inhibitor by receptor tyrosine kinases by Jyoti Verma and Harish Vashisth, https://doi.org/10.1002/prot.26685.
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Scott–Russel Linkage‐Based Triboelectric Self‐Powered Sensor for Contact Material‐Independent Force Sensing and Tactile Recognition
Authors: Seo Dongwon , Kong Jimin , Chung Jihoon 
Published: July 2024

AbstractThe rapid growth of Internet of Things (IoT) in recent years has increased demand for various sensors to collect a wide range of data. Among various sensors, the demand for force sensors that can recognize physical phenomena in 3D space has notably increased. Recent research has focused on developing energy harvesting methods for sensors to address their maintenance problems. Triboelectric nanogenerator (TENG) based force sensors are a promising solution for converting external motion into electrical signals. However, conventional TENG‐based force sensors that use the signal peak can negatively affect data accuracy. In this study, a Scott–Russell linkage‐inspired TENG (SRI‐TENG) is developed. The SRI‐TENG has completely separate signal generation and measurement sections, and the number of peaks in the electrical output is measured to prevent disturbing output signals. In addition, the lubricant liquid enhances durability, enabling stable force signal measurements for 270 000 cycles. The SRI system demonstrates consistent peak counts and high accuracy across different contacting surfaces, indicating that it can function as a contact material‐independent self‐powered force sensor. Furthermore, using a deep learning method, it is demonstrated that it can function as a multimodal sensor by realizing the tactile properties of various materials.
Survey assessing foot trimmer involvement in managing lameness in UK beef cattle
Authors: Fitzsimmonds Hannah M. , Fishwick John , Mahendran Sophie 
Published: July 2024

AbstractBackgroundCattle lameness is a significant welfare and economic problem facing the livestock industry. Published research has investigated foot trimming practices in dairy herds, but little is known about the practices in beef herds. Therefore, the objective of this study was to obtain information about the current practices of professional cattle foot trimmers concerning beef cattle within the UK.MethodsAn online survey comprising 16 questions was created using the Joint Information Systems Committee platform. The survey was open for 3 months.ResultsThere was a significant difference (p < 0.05) between the proportions of dairy cattle and beef cattle receiving preventative foot trims. Digital dermatitis was the most commonly recorded cause of lameness when a lame beef animal was trimmed by the respondents, followed by white line disease. A thematic analysis of foot trimmers' opinions of barriers to engagement on beef farms is presented, in addition to their opinions on veterinary involvement with beef lameness.LimitationsDistribution bias may have affected the results, as the survey was distributed online with support from the Cattle Hoof Care Standards Board and the National Association of Cattle Hoof Trimmers. The percentage of foot trimmers not affiliated with either professional body is not known.ConclusionFurther research on the impact of lameness on suckler and finishing cattle, including investigations into preventative actions to reduce lameness in beef systems, is warranted.
The History of the IOL Power Club: 2005–2025
Authors: Hoffer Kenneth J. 
Published: July 2024

AbstractThe IOL Power Club began at the 2024 ASCRS meeting because of an accidental meeting of 4 IOL power formula autthors (Aramberri, Haigis, Hoffer & Olsen). This led to them getting together, along with inviting 2 others (Norrby & Shammas), for a meeting to discuss the subject and socialize for 3 days in San Sebastian, Spain in September of 2005. It was so successful, they decided to form a Club and have meetings on an annual basis alternating between the EU and US. Over the years, others, with similar interests were invited to make presentations and some were later invited to join the Club. Early on, biometer and IOL manufacturers were asked to sponsor the meeting and send representatives to make scientific presentations. There were never product exhibits and commercialism was downplayed but, everyone was treated as equals. Over the ensuing 20 years, the IPC has continued these meetings darting around the EU and US and many subsequent endeavors have led to valuable contributions to this field, including this Open Access textbook dedicated to our Co-founder and colleague, Wolfgang Haigis PhD who is dearly missed since his passing in October 2019.
Influence of Anterior Chamber Depth, Lens Thickness, and Corneal Diameter on Intraocular Lens Power Calculation
Authors: Ferreira Tiago Bravo , Campos Nuno 
Published: July 2024

AbstractThe main IOL power formulas are described along with the input variables used by each of them to predict the IOL position and the refractive outcomes reported by published studies. An overview of measurements techniques of anterior chamber depth, lens thickness, and corneal diameter is given. The impact of these variables is illustrated for the Barrett Universal II, EVO, Haigis, Hill-RBF, Hoffer Q, Holladay 1, Holladay 2, Kane, Olsen, PEARL-DGS, and SRK/T formulas. With formulas that do not take the anterior chamber into account, eyes with a deeper anterior chamber are more likely to experience a hyperopic outcome compared to eyes with a shallow anterior chamber. With most formulas, a tendency toward a myopic shift occurs with thin lenses and toward a hyperopic shift with thick lenses. Corneal diameter has a minimal effect on IOL power calculation.