bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spinal Chordoma and Chondrosarcoma Treatment Experiences - A 20-Year Retrospective Study from Databases of Two Medical Centers
Authors: Kuo Pin-Lin , Yeh Yu-Cheng , Chang Koping , Tsai Tsung-Ting , Lai Po-Liang , Tsuang Fon-Yih 
Published: July 2024

Abstract

The research retrospectively analyzed cases of spinal chordoma and chondrosarcoma involving patients who received treatment at the two hospitals between 2001 and 2023. Among the 48 patients studied (39 chordoma and 9 chondrosarcoma cases), the average age was 53.9 ± 15.8 years, with a range of 17 to 86 years. Out of these patients, 43 underwent excision surgery and were categorized based on tumor margin into negative (R0) or microscopically positive (R1) margin (n = 14) and macroscopically positive (R2) margin (n = 29) groups. The mean overall survival (OS) for R0/R1 and R2 groups was 156.5 ± 19.3 and 79.2 ± 11.9 months, respectively (p value = 0.012). The mean progression-free survival (PFS) for R0/R1 and R2 was 112.9 ± 24.4 and 25.5 ± 5.5 months (p value < 0.001). The study showed that regardless of whether patients in the R0/R1 or R2 groups received radiation therapy (RT) or not, there was no significant improvement in OS or PFS. Specifically, the OS and PFS for the RT only group were 75.9 ± 16.6 and 73.3 ± 18.0 months. In conclusion, the recommended treatment approach for spinal chordoma and chondrosarcoma remains en bloc resection surgery with an appropriate margin. Patients who are unsuitable for or decline surgery may find a beneficial disease control rate with traditional external beam photon/proton therapy.
Factors associated with physical activity among Thai women with breast cancer postmastectomy at Siriraj Hospital, Thailand
Authors: Khobkhun Fuengfa , Wichaidit Piyaporn , Sa-nguanraksa Doonyapat , Phumphuang Surat , Puranasamriddhi Saowaluck , Lohsiriwat Visnu , Kaewkhuntee Watesinee 
Published: July 2024

Abstract

Background
The primary treatment for breast cancer patients is surgery, with the aim of reducing the risk of recurrence and minimize the spread of cancer cells. However, breast surgery often impacts physical activity (PA). Therefore, this study aimed to investigate factors associated with the PA level of Thai women with breast cancer after surgical mastectomy at Siriraj Hospital, Thailand.
Methods
Ninety-three participants were completed the questionnaires to accumulate the data for this study included personal information, information regarding medical treatment for breast cancer, the Global Physical Activity Questionnaire, perceived benefits, perceived barriers, perceived self-efficacy, interpersonal influence and situational influence, the Thai Body Image Index, and the Thai Hospital Anxiety and Depression Scale. Data was analyzed using descriptive statistics and Chi-square statistics (Odds-Ratio (OR) and 95% Confidence Interval (CI)).
Results
The study found that after post-mastectomy Thai women had sufficient PA (2.8 metabolic equivalent of tasks (METs)). It was also found that PA at work was associated with occupation, higher incomes, moderate satisfaction as assessed by the Thai Body Image Index, and higher levels of anxiety and depression. Additionally, participation in recreational activities was associated with older age, higher perceived self-efficacy, and greater interpersonal influence.
Conclusion
Understanding the factors associated with PA in Thai women with breast cancer postmastectomy is essential for developing comprehensive interventions that optimize patient health and well-being throughout the cancer journey. By exploring these connections more deeply, we can tailor supportive care strategies that address the holistic needs of individuals affected by breast cancer.
Estrogen Receptor Expression Pattern in Follicular Thyroid Cancers: A 23 Years Retrospective Multi-Centre Study in Jos Metropolis, North-Central, Nigeria.
Authors: Richard Samuel Kelechi , Kwaghe Barka Vandi , Emmanuel Innocent , Akpa Philip Ojile , Jimoh Abdulrazaq Ajanaku 
Published: July 2024

Abstract

Background
Follicular Thyroid cancers (FTC) are the second commonest malignancy of this organ and seen more often in females. Estrogen Receptor (ER) is vital in its pathogenesis and prognosis and those that express this marker may respond to selective medical targeted therapy. The aim of the study is to establish ER status of FTC as seen during the study period and this will give insight into possible response to medical targeted therapy.
Methods
This was a hospital based, retrospective multicenter study. The biodata were obtained from surgical pathology cancer registries. Sections from respective tissue blocks of included cases were reviewed, classified, subjected to immunohistochemistry, scored (using Allred) and analyzed using SPSS-20. Descriptive statistics was used to determine frequencies of each categorical variable, mean and mode of continuous variable.
Results
A total of 34 (36%) out of 95 cases of thyroid cancers were included. The mean, mode, median and age range were 49.8 ± 15.4, 44.5, 42 and 32–70 years respectively. Females were predominant (64.7%) with minimal invasive commonest. Three cases (8.8%) were only positive for ER out of which all (100.0%) were females. Two of the positive cases had score 3(5.9%) while 1 had score 5(2.9%).
Conclusions
Majority of the follicular thyroid cancer cases were negative for estrogen receptors and were seen exclusively in female of reproductive age group.
Investigation the role of SIRT3, SIRT7, NFATC1, and PDL-1 genes in Androgenetic Alopecia
Authors: Abbasian Hadis , Noruzinia Mehrdad , Garshasbi Masoud 
Published: July 2024

Abstract

Background Androgenetic Alopecia (AGA) stands as the most prevalent form of hair loss, affecting the hair follicles (HFs). aging emerges as a prominent contributor in this condition. In this study, our aim is to elucidate the expression patterns of candidate genes—SIRT3, SIRT7, NFATC1, and PDL-1—known to exhibit differential expression levels during HF aging, and to underscore the role of aging in AGA.Material and Methods mesenchymal stem cells (MSCs) were isolated from the vertex and occipital regions of six men affected by AGA. The aim was to assess the expression levels of SIRT3, SIRT7, NFATC1, and PDL-1 genes. RNA extraction was performed followed by cDNA synthesis, and gene expression levels were quantified using real-time PCR. To validate the experimental findings, two different RNA-seq datasets relevant to the study were analyzed using R software.Results In the present study, experimental tests revealed that the expression levels of SIRT3 and SIRT7, known to decrease during HF aging, were diminished in AGA samples as well. Conversely, the mean value of NFATC1 and PDL-1 expression level, which are known to increase during HF aging, were found to be elevated in AGA samples. Moreover, bioinformatic analyses provide additional support for the role of SIRT3, SIRT7, NFATC1, and PDL-1 in AGA pathogenesis.Conclusion while SIRT3 and SIRT7 may play critical roles in AGA development, further research is needed to elucidate the significance of NFATC1 and PDL-1 in this context and to explore their potential as therapeutic targets for AGA treatment.
General Endotracheal Anesthesia vs Total Intravenous Anesthesia for Children Undergoing Low-risk Cardiac Catheterization
Authors: Fashina Oluwatomini , Vogel Elizabeth , Swan Elena Ashikhmina , Anderson Jason , Aganga Devon , Gleich Stephen , Stensrud Paul , Taggart Nathaniel 
Published: July 2024

Abstract

Introduction:
Historically, children undergoing cardiac catheterization have been managed with general endotracheal anesthesia (GETA). However, recent practice has favored general anesthesia with total intravenous anesthesia (TIVA). This study compares procedural outcomes in the pediatric cardiac catheterization laboratory (PCCL) for children undergoing low-risk cardiac catheterization with GETA vs. TIVA.
Methods:
We reviewed all patients aged 1–12 years, who underwent outpatient diagnostic or simple interventional catheterization from January 2016 – September 2023. Patients were divided into cohorts by type of anesthesia (GETA vs. TIVA). The primary outcome measure was total patient time in the PCCL (“door-to-door” time). Secondary outcomes were procedure duration (“sheath time”), length of hospital stay, and the major adverse event (MAE) rate.
Results:
A total of 401 patients were included. Of these patients, 226 underwent GETA and 175 underwent TIVA. There were 148 interventional procedures and 72 patients had single-ventricle physiology. There was no significant difference between the two cohorts in terms of demographic factors such as age, weight, procedure indication and physiological complexity as well as outcomes such as sheath time, hospital stay and MAE. However, the average door-to-door time of the TIVA cohort was 25 minutes shorter than the GETA cohort (p < 0.001).
Conclusions:
In this single center, retrospective study of anesthesia management for children undergoing low-risk cardiac catheterization, TIVA is associated with significantly shorter door-to-door time in the PCCL without an increase in procedure duration, hospital stay, or rate of complications. These findings have potential clinical significance supporting increased use of TIVA during pediatric cardiac catheterization.
The Intelligent Selenium-Enriched Tea WitheringControl System
Authors: Ren Shuang , Fan Jinzhao , Lu Didi , Liu Sanjun 
Published: July 2024

Abstract

This paper addresses the low level of intelligence in tea processing equipment in Enshi Prefecture by designing an intelligentwithering control system based on the STMicroelectronics 32-bit Microcontroller (STM32). This control system can achievereal-time monitoring of the withering environment and automate the control of heating and ventilation dehumidification modules.By integrating IoT technology, relevant users can view the tea production process via mobile devices, enabling intelligent andremote production operations. Application results show that the system operates stably, accurately measures temperature andhumidity in the withering environment, and achieves a control precision of ±1% through a fuzzy control algorithm. It effectivelymeets the needs of tea processing in Enshi Prefecture. The system not only optimizes traditional processing workflows,enhancing processing efficiency and tea quality, but also provides new technological means for tea processing enterprises,contributing to the development and upgrading of the local tea industry.
Stenotrophomonas maltophilia endogenous endophthalmitis in pediatric age group
Authors: Jain Tanya , Muralidhar Alankrita , Gandhi Arpan 
Published: July 2024

Abstract

Background: We report a unique case of Stenotrophomonas maltophilia-related pediatric endogenous endophthalmitis.
Case presentation: A 10-year-old male presented with redness and loss of vision in his right eye for two weeks. Clinical examination and ultrasound features were suggestive of endophthalmitis, most likely endogenous due to the absence of a history of trauma or intraocular intervention. Following vitrectomy and appropriate intravitreal antibiotics, the vision improved to 20/80. Vitreous culture revealed a gram-negative bacillus Stenotrophomonas maltophilia.
Conclusion: Timely recognition of this pathogen and management as per antibiotic sensitivity can help salvage functional vision in this condition.
Breastfeeding with Primary Low Milk Supply: A Phenomenological Exploration of Mother’s Lived Experiences of Professional and Peer Support
Authors: Whelan Caoimhe , O'Brien Denise , Hyde Abbey 
Published: July 2024

Abstract

Background: Most women can produce enough milk to exclusively breastfeed. However, a small cohort are prevented from doing so due to a condition known as primary low milk supply.
Aim: To provide new insights into how mothers with primary low milk supply experience help and support from professionals, volunteers, and partners.
Methods: Interpretative phenomenological analysis was used to explore the lived experiences of nine breastfeeding mothers with primary low milk supply. Hour-long interviews were conducted over Zoom.
Results: Being with Others is one of four superordinate themes identified in this study. This theme concerned the participants’ experiences of receiving professional, peer, and voluntary breastfeeding supports. It also considers how participants were supported by their partners. Four sub-themes were identified: Disconnected Encounters, Perceiving Judgement from Others, Being in a Safe Space and Having a Saviour.
Conclusion: The interactions that mothers with primary low milk supply have with various others in their world (health care professionals, lactation consultants, peer breastfeeding supporters, and partners) can shape how they view themselves and can have a profound impact on their breastfeeding journey. The encounters of participants with healthcare professionals revealed a lack of rapport, intrusive hands-on support, poor perceived quality of breastfeeding support and a heightened sensitivity to language and tone. Mothers with primary low milk supply value empathy and emotional support from lactation professionals as much as they value skilled lactation support. We recommend that healthcare professionals receive education concerning primary low milk supply and communication skills training on the provision of sensitive person-centred breastfeeding support.
Ultrastructure of disc found in the chorion of Atlantic salmon (Salmo salar) embryos
Authors: Pérez-Atehortúa Maritza , Sandoval-Vargas Leydy , Risopatrón Jennie , Farías Jorge , Villalobos Elías Figueroa , Valdebenito Iván 
Published: July 2024

Abstract

The chorion is an acellular envelope that surrounds fish oocytes and embryos, playing a crucial role in protection against environmental factors until hatching. In salmonids, several chorion malformations have been documented, including white-spotted (disc-like) chorion. This study focused on investigating the ultrastructural modifications of the chorion with discs and their possible influence on embryonic viability in Atlantic salmon. A total of 136 females were included in the study. The incidence of disc chorion was evaluated at 130 °h and in pigmented eye embryos at 280 ATU (accumulated thermal units). Scanning electron microscopy (SEM) was used for this ultrastructural characterization. The results revealed that 3.17% of females had embryos with discs in the chorion at 130 °h, with a mean of 1.21 ± 7.24% of affected embryos per female. At 280 ATU, 15% of the females had embryos with discs in the chorion, with a mean of 0.45 ± 2.17% per female. Females with this malformation were observed to have a slightly higher fertilization rate (75 ± 21.21%) compared to females without this malformation (74.2 ± 23.7%). Embryonic survival at 280 ATU for both groups was 70.1 ± 20.6% and 71.6 ± 21.0%, respectively. Although a clear origin for the chorion with disc malformation is not known, the possibility is raised that it may be due to pathological conditions specific to the female and that it probably occurs in a similar way to nephrocalcinosis, by bioaccumulation of elements in the chorion during its synthesis. Further studies are needed to better understand this malformation to help refine economic projections in salmon farms dedicated to embryo production.
Fine-Grained Meetup Events Extraction Through Context-Aware Event Argument Positioning and Recognition
Authors: Lin Yuan-Hao , Chang Chia-Hui , Chuang Hsiu-Min 
Published: July 2024

Abstract

Extracting meetup events from social network posts or webpage announcements is the core technology to build event search services on the Web. While event extraction in English achieves good performance in sentence-level evaluation WKGS19,the quality of auto-labeled training data via distant supervision is not good enough for word-level event extraction due to long event titles JISE2022.Additionally, meetup event titles are more complex and diverse than trigger-word-based event extraction. Therefore, the performance of event title extraction is usually worse than that of traditional named entity recognition.In this paper, we propose a context-aware meetup event extraction (CAMEE) framework that incorporates a sentence-level event argument positioning model to locate event fields (i.e., title, venue, dates, etc.) within a message and then perform word-level event title, venue, and date extraction.Experimental results show that adding sentence-level event argument positioning as a filtering step improves the word-level event field extraction performance from 0.726 to 0.743 macro-F1, outperforming large language models like GPT-4-turbo (with 0.549 F1) and SOTA NER model SoftLexicon (with 0.733 F1). If we focus on the main event, the proposed model achieves 0.784 macro-F1.
Nisin A-producing Lactococcus cremoris formulations for pre- and post-milking teat disinfection modulate the bovine milk microbiota
Authors: Gazzola Alessandra , Ceccarani Camilla , Castiglioni Bianca , Biscarini Filippo , Morandi Stefano , silvetti tiziana , piccinini renata , Brasca Milena , Cremonesi Paola 
Published: July 2024

Abstract

Background - Bovine mastitis is a major challenge in dairy farms. Since the agents commonly used for pre- and post-dipping can affect the udder health by modifying milk microbiota, alternative products are needed. This study aimed to evaluate the effect of the use of pre- and post-dipping formulations containing the Nisin A-producing Lactococcus cremoris FT27 strain (treated group, TR) on the abundance and biodiversity of milk microbiota as compared to iodine-based commercial disinfectants (control group, CTR) during a three-month trial. The experiment was conducted on 20 dairy cows, divided into two groups (CTR and TR) of 10 lactating cows each. Milk samples were collected from two selected healthy quarters of each cow at 3 time points. Microbial communities were investigated by cultural and sequence-based methods, and analyzed through bioinformatic and statistical approaches. Results - Clear differences in bacterial community composition were observed among groups, with higher species richness in TR, especially of Staphylococcus, Enterococcus, Lactococcus, and Streptococcus genera. The microbiota was dominated by Firmicutes, followed by Actinobacteriota, Proteobacteria, and Bacteroidota. Staphylococcaceae family was significantly higher in TR (p < 0.009), whereas Carnobacteriaceae, Mycobacteriaceae, and Pseudomonadaceae were significantly lower (p = 0.005, p = 0.001, and p = 0.040, respectively). CTR had considerably higher abundances of the genera Alkalibacterium (p = 0.011), Pseudomonas_E (p = 0.045), Corynebacterium (p = 0.004), and Alloiococcus (p = 0.004), and lower abundances of Staphylococcus (p < 0.009). Milk microbiota changed noticeably during the experimental period, regardless of treatment. A significant decrease was observed in both groups for Firmicutes_A phylum, with an increment in Actinobacteriota phylum, Propionibacteriaceae family, and Cutibacterium genus. Streptococcaceae significantly decreased in CTR (p = 0.013) and rose in TR (p = 0.001). Several differences were observed between the two groups during the experimental period. Streptococcus genus almost disappeared in CTR (p = 0.013), whereas it significantly increased in TR (p = 0.001). Three and twelve enriched groups were significantly identified respectively in CTR and TR using LEfSe. Conclusions - Overall, the use of Nisin A-based teat dip formulations was associated with a greater microbial diversity throughout the experimental period compared to commercial one. Although seasonality may have influenced the changes in the most prevalent taxa abundances, the experimental formulations maintained higher milk biodiversity, thus suggesting the ability of Nisin A to prevent alterations of milk microbiota.
ATKB-PID: An adaptive control method for micro tension under complex hot rolling conditions
Authors: Xinkai XU , Xiangrong SONG , Zheng QI 
Published: July 2024

Abstract

At present, the controller parameters in hot rolling roughing microtension control cannot be adaptively adjusted according to the changes of working conditions, which affects the width accuracy as well as the stability of production. Therefore, an ATKB-PID adaptive micro tension control method is proposed in this paper. A linear attention layer is added to the BP-PID controller and a KNN method is established to predict the optimal learning rate and inertia coefficient under actual working conditions. In addition, the objective function is designed according to the production index to improve the performance of the model. Through the comparison experiments with the widely used RBF-BP control and BP-PID control, it is verified that the ATKB-PID control method proposed in this paper has small steady state error and short adjustment time. The ATKB-PID control method can meet the complex and variable micro tension control conditions in thermal roughing, and has good application prospects.
Cross-disciplinary Analysis of Modern Chinese Classroom Interaction Discourse Patterns - An Empirical Study Based on Experienced Chinese Teacher
Authors: Yang Xiaoyu , Jansem Anchalee 
Published: July 2024

Abstract

This study adopts a cross-disciplinary perspective to focus on the interactive discourse in Modern Chinese classrooms, exploring the interactive pattern between teachers and students, discourse characteristics, and their impact on learning outcomes. Employing both classroom observation and conversation analysis, this empirical study was conducted on Modern Chinese classes in the Chinese Language and Literature Department of Z University. After a detailed analysis of the transcribed classroom interaction discourse, six main interaction discourse patterns were identified: IRF, [InRn]F, InRn, I[RnFn], [InRn]FR, and IR[FnRn]. The findings indicate that, while the traditional IRF model persists as the predominant form of classroom interaction, more complex interactive patterns (such as [InRn]F) are more effective in enhancing student participation and discourse volume in the classroom. This study offers practical recommendations on motivating student participation and elevating the quality of classroom interaction, providing valuable insights for the reform of Modern Chinese language teaching.
CRISPR/Cas9 alter NFYA binding site on CD44-regulating cis-element and control CD44 expression in breast cancer cells
Authors: Salem Sohair , Yahya Shaymaa MM 
Published: July 2024

Abstract

Background
CRISPR/Cas9 is used for editing of non-coding sequence. This study tested the involvement of downstream cis-element in regulating CD44 expression and the possibility of using CRISPR/Cas9 system to manipulate the transcription factor binding site. Bioinformatic tools predicted two binding sites (P1 and P2) for NFYA transcription factors. CRISPR/Cas9 was used to knockout NFYA gene and alter the NFYA binding site (P2).
Results
The data revealed decrease of CD44 gene expression and CD44+ CD24− sub-population after editing of P2 sequence more than the decrease resulted from editing of NFYA gene itself, confirming the involvement of NFYA in regulating CD44 gene. Both editing inhibited the migration ability of MDA-MB-231 cells. Unlike editing of NFYA gene, altering P2 sequence induced apoptosis. CHIP assay revealed that NFY have the ability to bind both P1 and P2 sequences, with higher enrichment in case of P2 than P1. After performing site-directed mutagenesis and luciferase assay we confirmed the involvement of both P1 and P2 in gene regulation, with higher potential in case of P2 than P1.
Conclusion
The findings confirmed the regulation of CD44 by NFYA and the efficacy of using CRISPR/Cas9 in altering the binding site, and downregulation of CD44.