bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury
Authors: Joiner Danese M , Less Kennen D , Van Wieren Emily M , Zhang Yu-Wen , Hess Daniel , Williams Bart O 
Published: March 2014

Abstract
Introduction
Ligament and meniscal damage can cause joint disease. Arthritic joints contain increased amounts of epidermal growth factor receptor (EGFR) protein, and polymorphisms in EGFR are associated with arthritis risk. The role of endogenous EGFR regulation during joint disease due to ligament and meniscal trauma is unknown. Mitogen-inducible gene 6 (MIG-6) can reduce EGFR phosphorylation and downstream signaling. We examined the effect of EGFR modulation by MIG-6 on joint disease development after ligament and meniscus injury.

Methods
Knee ligament transection and meniscus removal were performed surgically on mice homozygous for a global inactivating mutation in MIG-6 (Mig-6
−/−
) and in wild-type (WT) animals.

Results
Two weeks after surgery, Mig-6
−/−
mice had bone erosion as well as greater fibrous tissue area and serum RANKL concentration than WT mice. Four weeks after surgery, Mig-6
−/−
mice had less cartilage and increased cell proliferation relative to contralateral control and WT knees. Increased apoptotic cells and growth outside the articulating region occurred in Mig-6
−/−
mice. Tibia trabecular bone mineral density (BMD) and the number of trabeculae were lower in surgically treated knees relative to the respective control knees for both groups. BMD, as well as trabecular thickness and number, were lower in surgically treated knees from Mig-6
−/−
mice relative to WT surgically treated knees. Phosphorylated EGFR staining in surgically treated knees decreased for WT mice and increased for Mig-6
−/−
mice. Fewer inflammatory cells were present in the knees of WT mice.

Conclusion
Mig-6
−/−
mice have rapid and increased joint damage after ligament and meniscal trauma. Mig-6 modification could lessen degenerative disease development after this type of injury.
Hepatocyte Growth Factor and p38 Promote Osteogenic Differentiation of Human Mesenchymal Stem Cells
Authors: Aenlle Kristina K. , Curtis Kevin M. , Roos Bernard A. , Howard Guy A. 
Published: March 2014

Abstract
Hepatocyte growth factor (HGF) is a paracrine factor involved in organogenesis, tissue repair, and wound healing. We report here that HGF promotes osteogenic differentiation through the transcription of key osteogenic markers, including osteocalcin, osterix, and osteoprotegerin in human mesenchymal stem cells and is a necessary component for the establishment of osteoblast mineralization. Blocking endogenous HGF using PHA665752, a c-Met inhibitor (the HGF receptor), or an HGF-neutralizing antibody attenuates mineralization, and PHA665752 markedly reduced alkaline phosphatase activity. Moreover, we report that HGF promotion of osteogenic differentiation involves the rapid phosphorylation of p38 and differential regulation of its isoforms, p38α and p38β. Western blot analysis revealed a significantly increased level of p38α and p38β protein, and reverse transcription quantitative PCR revealed that HGF increased the transcriptional level of both p38α and p38β. Using small interfering RNA to reduce the transcription of p38α and p38β, we saw differential roles for p38α and p38β on the HGF-induced expression of key osteogenic markers. In summary, our data demonstrate the importance of p38 signaling in HGF regulation of osteogenic differentiation.
In Situ Picosecond XAFS Study of an Excited State of Tungsten Oxide
Authors: Uemura Yohei , Uehara Hiromitsu , Niwa Yasuhiro , Nozawa Shunsuke , Sato Tokushi , Adachi Shinichi , Ohtani Bunsho , Takakusagi Satoru , Asakura Kiyotaka 
Published: March 2014

Abstract
The electronic state modification and the decay process of WO3 after photoabsorption were followed using picosecond X-ray absorption fine structure (XAFS) spectroscopy. The W d(eg) orbital was filled by transition from the oxygen valence state. The decay process is explained mostly by a first-order process with a rate constant k = 0.5 ± 0.1 ns−1. The UV optical length is extremely important to follow the photoreduction process using XAFS spectroscopy.
Coordination Programming in the Design of Porous Coordination Polymers: Tuning of the Electronic Activity of Frameworks for Selective Nitrogen Monoxide Trapping
Authors: Kosaka Wataru , Yamagishi Kayo , Matsuda Ryotaro , Kitagawa Susumu , Takata Masaki , Miyasaka Hitoshi 
Published: March 2014

Abstract
A change of building block from [Ru2II,II(p-FPhCO2)4] to [Ru2II,II(4-F-2-OMePhCO2)4] in a phenazine (phz)-bridged [Ru2II,II] chain compound led to a high selectivity toward nitrogen monoxide (NO) in the adsorption characteristics. High selectivity was observed despite the fact that electronically negative sites that enable close contact with NO molecules are not present in the pores, in contrast to [Ru2II,II(4-Cl-2-OMePhCO2)4(phz)], which also exhibited selective NO adsorption.
Array of Single-cell Pairs on a Microwell Array Based on Positive Dielectrophoresis
Authors: Yoshimura Yuki , Fujii Chiaki , Tomita Masahiro , Mizutani Fumio , Yasukawa Tomoyuki 
Published: March 2014

Abstract
We developed a simple device with 400 (20 × 20) microwells that integrated the cell positioning and cell pairing of two different types of cells based on positive dielectrophoretic manipulation. We fabricated a star-shaped micropole array on a conductive substrate and used the areas encircled with micropoles as microwells for positioning the cells. The different types of cells were successively trapped to form vertical cell pairs in the microwells. The time required for the formation of the array of cell pairs was as short as 1 min.
UNA APROXIMACIÓN A LOS CAMBIOS EN EL DISCURSO MATEMÁTICO GENERADOS EN EL PROCESO DE DEFINIR
Authors: María Escudero Isabel , María Gavilán José , Sánchez Matamoros Gloria 
Published: March 2014

En este trabajo nos situamos en una perspectiva sociocultural para abordar los cambios que se manifiestan en el discurso matemático de los estudiantes cuando tratan de definir un objeto matemático. En particular, nos planteamos si es posible caracterizar el procedimiento de cambio apoyándonos en herramientas provenientes de dicha perspectiva. Los participantes fueron 51 estudiantes de edades comprendidas entre 16 y 21 años. El análisis realizado nos permitió identificar diferentes cambios en el discurso matemático de los estudiantes, a partir de la caracterización de las relaciones identificadas entre narrativas asumidas y rutinas que se han puesto de manifiesto en el discurso. Estos cambios nos han permitido aproximarnos al proceso de aprendizaje de los estudiantes.
Ghosts in the Medium: The Haunting of Heidegger‘s Technological Question
Authors: Rufo Kenneth 
Published: March 2014

Abstract
In an attempt to orient media ecology along a slightly different trajectory, this article expands the consideration of the medium by looking to its triple promise as a technology, a psychic medium, and in-between. This article blends together two seeming disparate case studies—Rudyard Kipling's early take on wireless telegraphy (today thought in terms of radio) and Martin Heidegger's discussion of language and technics—in order to demonstrate how media “haunt” many of our “discussions” of technology. Turning to Jacques Derrida, who has long been concerned with mediation, this article attempts to interrogate Heidegger on behalf of Kipling’s radio, in order to see how the medium upsets the basic binary of language/ technology, and to explore how mediation dissolves the philosophical presumption of presence. At the same time, this article argues that philosophers like Heidegger confront this dissolution with a rhetorical trick still popular today: the linking of past media ecologies to a more stable, more authentic spiritual component, a technostalgia that attempts to exorcize today's “ghosts in the medium.”
Reviews
Authors: Bennett Stephanie , Knapp Jessica , Rose Phillip 
Published: March 2014

Abstract
Strate, Lance, Ron L. Jacobson, and Stephanie Gibson, eds. Communication and Cyberspace: Social Interaction in an Electronic Environment (2nd ed.). Cresskill, NJ: Hampton Press, 2003. 416 pp. Paper $34.50, ISBN 1-57273-394-2.
Starr, Paul. The Creation of the Media: Political Origins of Modern Communications. New York: Basic Books, 2004. 448 pp. Cloth $27.50, ISBN 0-465-08193-2.
Albrecht, Robert. Mediating the Muse: A Communications Approach to Music, Media and Culture Change. Cresskill, NJ: Hampton Press, 2004. 450 pp. Paper $35.00, ISBN 1-57273-511.2
Language at preschool in Europe: Early years professionals in the spotlight
Authors: Michel Marije C. , Kuiken Folkert 
Published: March 2014

AbstractOver the past few decades early years education throughout Europe has experienced many changes due to higher numbers of children attending centres for early childhood education and care (ECEC), a growing linguistic and cultural diversity in society and a shift from care to education with the focus on preparing children for entry to primary school. These changes have brought with them an expectation from policy makers, researchers and parents for better ECEC. Language support for children is often named as one of the key aspects of high-quality childcare because of its importance in successful entry to and progression within the future educational career of a child. However, rather little is known about how early years professionals meet the linguistic demands of twenty-first century multilingual Europe. The present special issue tries to fill this gap by giving a platform to five European investigations into language at preschool in Europe with a focus on early years educators’ competences, knowledge, skills, beliefs and needs. This introductory article aims to prepare the reader for the contributions that follow in this special issue. We first describe current policy and practice of language support in European ECEC with regard to children’s and educators’ needs. Then, we review all the contributions and provide a summary focusing on the diversity as well as the commonalities of the five investigations, before formulating an outlook for future work.
Determination of the mechanical properties of radiata pine timber by means of longitudinal and transverse vibration methods
Authors: Arriaga Francisco , Monton Joaquin , Segues Edgar , Íñiguez-Gonzalez Guillermo 
Published: March 2014

Abstract
Bending properties have been determined by mechanical testing [modulus of elasticity (MOE) and modulus of rupture (MOR)] and by means of longitudinal (L) and transverse (T) vibration nondestructive methods on 150 sawn timber pieces of Pinus radiata D. Don, with the dimensions of 80×120 mm cross-section and 2500 mm long, from Catalonia, Spain. The fundamental vibration frequency was measured by recording the sound produced by hitting the piece in L and T directions, and this signal was analyzed by fast Fourier transform sound analyzer. The dynamic MOE was obtained for both procedures and compared with static MOE and MOR. The notion of concentrated knot diameter ratio (CKDR) was introduced to improve the prediction of MOR. CKDR gives better results when this parameter is referred to the central portion of piece length. Both methods (L and T frequencies) have similar accuracy in prediction of mechanical properties, but the first one is simpler and has some practical advantages. The timber graded with this nondestructive method offers better results than the visual grading rules for the same output.
New Nonlinear Takagi–Sugeno Vehicle Model for State and Road Curvature Estimation via a Nonlinear PMI Observer
Authors: Yacine Zedjiga , Ichalal Dalil , Oufroukh Naima Ait , Mammar Said , Djennoune Said 
Published: March 2014

AbstractThe present article deals with an observer design for nonlinear vehicle lateral dynamics. The contributions of the article concern the nonconsideration of any force model and the consideration that the longitudinal velocity is time varying, which is more realistic than the assumption that it is constant. The vehicle model is then represented by an exact Takagi–Sugeno (TS) model via the sector nonlinearity transformation. A proportional multiple integral (PMI) observer based on the TS model is designed to estimate simultaneously the state vector and the unknown input (lateral forces and road curvature). The convergence conditions of the estimation error are expressed under LMI formulation using the Lyapunov theory, which guaranties a bounded error. Simulations are carried out for comparison between the conventional PI observer, the enhanced PI observer, and the PMI observer. Finally, experimental results are provided to illustrate the performances of the proposed PMI observer.
Association of Gingival Crevicular Fluid Cortisol/Dehydroepiandrosterone Levels With Periodontal Status
Authors: Cakmak Omer , Alkan B. Arzu , Ozsoy Saliha , Sen Ahmet , Abdulrezzak Ummuhan 
Published: March 2014

Background: The aim of the present study is to examine whether anxiety and depression scale scores change with regard to clinical periodontal status and to investigate the association between the levels of stress‐related hormones in gingival crevicular fluid (GCF) and extent/severity of periodontal disease.Methods: One hundred twenty participants who fulfilled the study inclusion criteria were chosen. Patients with chronic periodontitis (CP) and those with healthy periodontal tissues/mild gingivitis were included. The clinical examinations were performed on the day after the psychologic evaluations which included anxiety and depression measurements. GCF sampling was undertaken the following day. Commercially available enzyme‐linked immunosorbent assay kits were used to determine GCF cortisol and dehydroepiandrosterone (DHEA) levels. Study groups were assigned as follows: group 1, non‐periodontitis; group 2, localized CP; and group 3, generalized CP.Results: There were no significant differences with respect to age, sex, education, income level, occupation, or smoking history among the groups (P >0.05). There were no significant differences between the non‐periodontitis and CP groups for any of the psychosocial scales (P >0.05). Group 3 had significantly higher mean DHEA scores compared with group 1 (P <0.05); however, the median cortisol scores showed no statistically significant differences among the three groups (P >0.05).Conclusions: Anxiety/depression scores and GCF cortisol levels did not show any difference with regard to clinical periodontal status. However, a significant association was found between elevated levels of GCF DHEA and the severity of periodontitis.
Book-Tax Conformity and Earnings Management: Insights from European One- and Two-Book Systems
Authors: Watrin Christoph , Ebert Nadine , Thomsen Martin 
Published: March 2014

ABSTRACT:
There is an ongoing debate in the U.S. about the effect of book-tax conformity on earnings management in consolidated statements. Although both one- and two-book systems are present in Europe, European data have not been used to contribute to this debate. In this study, we examine the influence of one- and two-book systems on earnings management using consolidated statements and single financial statements of European firm-years from 2004 to 2011. A one-book system is defined as a situation in which financial accounting income and taxable income are highly conformed, whereas a two-book system is characterized by differences between consolidated financial income and taxable income. We find that firms in one-book systems show significantly more (downward) earnings management in their consolidated statements than do firms in two-book systems. With these findings, we contribute to the U.S. policy debate on book-tax conformity and earnings management.
Cortical surface complexity in a population-based normative sample
Authors: Dombroski Brynn , Nitzken Matthew , Elnakib Ahmed , Khalifa Fahmi , Switala Andrew , El-Baz Ayman , Casanova Manuel 
Published: March 2014

AbstractMRI studies on abnormal brain development are dependent on the quality, quantity, and type of normative development data available for comparison. Limitations affecting previous studies on normative development include small sample sizes, lack of demographic representation, heterogeneous subject populations, and inadequate longitudinal data. The National Institutes of Health Pediatric MRI Data Repository (NIHPD) for normative development was designed to address the aforementioned issues in reliability measures of control subjects for comparison studies. The subjects were recruited from six Pediatric Study Centers nationwide to create the largest, non-biased, longitudinal database of the developing brain. Using the NIHPD, we applied a 3D shape analysis method involving spherical harmonics to identify the cortical surface complexity of 396 subjects (210 female; 186 male) between the ages of 4.8 y and 22.3 y. MRI data had been obtained at one, two, or three time points approximately two years apart. A total of 144 participants (79 female; 65 male) provided MRI data from all time points. Our results confirm a direct correlation between cortical complexity and age in both males and females. Additionally, within the examined age range, females displayed consistently and significantly greater cortical complexity than males. Findings suggest that the underlying neural circuitry within male and female brains is different, possibly explaining observations of sexual dimorphism in social interaction, communication, and higher cognitive processes.
Interleukin-6 is linked to longitudinal rates of cortical thinning in aging
Authors: McCarrey Anna , Pacheco Jennifer , Carlson Olga , Egan Josephine , Thambisetty Madhav , An Yang , Ferrucci Luigi , Resnick Susan 
Published: March 2014

AbstractInterleukin-6 (IL-6) is a pro-inflammatory cytokine produced by immune cells and other cell types such as microglia throughout the brain. Higher levels of IL-6 in older adults have been cross-sectionally and longitudinally associated with physical and cognitive impairment, as well as increased dementia risk. The association between IL-6 levels and structural and functional brain changes is less clear. In the present study, we investigated the relationship between IL-6 concentrations and cortical thinning with aging. Magnetic Resonance Imaging (MRI) scans from the Baltimore Longitudinal Study of Aging were analyzed for 121 older subjects (M = 69.3; SD = 7.3; range = 56.1–85.9 yrs) who were repeatedly tested over an average period of 7.5 yrs, and who remained non-demented for the entire follow-up period. The Freesurfer longitudinal processing stream was utilized for image processing, and IL-6 measures were based on serum ELISA assays averaged across time points. Results showed that higher mean IL-6 concentrations were associated with accelerated annual rates of cortical thinning in the inferior temporal poles bilaterally. Additional pronounced regions of IL-6 -accelerated thinning included the transverse frontopolar gyri within the left hemisphere, and subcentral gyrus and sulcus within the right hemisphere. Our results indicate that sustained high levels of the inflammatory biomarker IL-6 are associated with regionally increased rates of age-related cortical thinning. These data build on previous findings that link IL-6 to chronic disease and demonstrate one mechanism through which high levels of inflammation may have adverse effects on physical and cognitive function.
Amyloid imaging in Alzheimer’s disease: a potential new era of personalized medicine?
Authors: Leuzy Antoine , Zimmer Eduardo , Gauthier Serge , Rosa-Neto Pedro 
Published: March 2014

AbstractRecent advances along clinical and neuropathological lines, as well as in our ability to detect the deposition of β-amyloid (Aβ) in vivo using positron emission tomography (PET), have helped redefine Alzheimer’s disease (AD) as a dynamic clinicobiological entity. On the basis of these advances, AD is now conceptualized as a continuum comprising asymptomatic, minimally symptomatic, and dementia phases, with detection of brain Aβ — in particular, via PET amyloid imaging — central to the diagnostic process. In this respect, [18F]florbetapir (Amyvid™) and [18F]flutemetamol (Vizamyl™) have recently received approval for clinical use from the Food and Drug Administration (FDA) and the European Medicines Agency (EMA), with additional radiofluorinated tracers for detection of Aβ in phase III trials. Recent initiatives such as the Alzheimer’s Disease Neuroimaging Initiative (ADNI) suggest that Aβ production, oligomerization and aggregation begins many years, possibly decades, before detectable cognitive impairment, with Aβ shown to associate with cognitive decline and conversion to dementia. While personalized medicine has now emerged as a prospect for the field, the recent decision by the Centers for Medicare & Medicaid Services (CMS) — who declined to cover the cost of amyloid PET imaging citing insufficient evidence to support its clinical utility — highlights that such a move may be premature.
Macroeconomic analysis of road vehicles related environmental pollution in Hungary
Authors: Török Árpád , Török Ádám 
Published: March 2014

AbstractThe article aims to examine the relationship between road transport and macro economy, especially the use of fossil energy in transport sector. Nowadays environmental pollution is a key issue on the EU level as well as in Hungary. Lots of effort have been already done in order to decrease emissions in road transport, but a lot more need to be done. The article aims to prove that the only possible solution is technological innovation in order to reach emission reduction target without decline of the GDP. The basic idea is to ensure sustainable development, to decrease environmental pollution in road transport without harming the economy. In the EU and in Hungary road vehicles are powered by fossil fuelled internal combustion engines. This paper aims to analyse the role of the fossil fuel-based road transport sector within the economy with the usage of constant elasticity substitution (CES) production functions. Authors have built CES production function for Hungary. Parameters were calculated based on the validated model.
Experimental and numerical investigation of slabs on ground subjected to concentrated loads
Authors: Øverli Jan 
Published: March 2014

AbstractAn experimental program is presented where a slab on ground is subjected to concentrated loading at the centre, the edges and at the corners. Analytical solutions for the ultimate load capacity fit well with the results obtained in the tests. The non-linear behaviour of the slab is captured by performing nonlinear finite element analyses. The soil is modelled as a no-tension bedding and a smeared crack approach is employed for the concrete. Through a parametric study, the finite element model has been used to assess the influence of subgrade stiffness and shrinkage. The results indicate that drying shrinkage can cause severe cracking in slabs on grade.