bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of TLC densitometry method for the determination of Gliclazide in tablet dosage form
Authors: Retnaningtyas Yuni , Wulandari Lestyo , Erliana Feby 
Published: September 2012

Some tablet pharmaceutical preparations containing Gliclazide as sole active ingredient, are marked now in Indone-sia. The determination of the component of preparation both qualitatively and quantitatively is important to ensure quality of the product. This research is aimed to develop a TLC method to analyze gliclazide in its single component tablet formulation. Gliclazide were dissolved with chloroform. Gliclazide was chromatographed on silica Gel 60 F254 TLC plate using toluene: ethyl acetate in the ratio of 1:1 (v/v) as mobile phase. Gliclazide showed Rf value of 0.58 and was scanned at 234nm using Camag TLC Scanner 3. This method validation showed a good linearity with correlation coefficient (r) of 0.999 while the coefficient of variation of the regression function (Vx0) = 2.406%. Specificity showed calculation of purity and identity more than 0.99. The limit of detection (LOD) and the limit of quantification (LOQ) of the method was respectively 28.78 and 86.35 ng/spot respectively. The mean absolute recovery of Gliclazide from the simulation sample was 100.5% ± 0.113 and the method precision was less than 5.3% whereas the mean of the recovery data was 100.3%. The proposed method has been applied to the determination of Gliclazide in commercial tablet formulations and the recovery of label claim were100.494%±0.348 for brand A and 100.111%±1.257% for brand B. The developed method was successfully used for the assay of gliclazide. The method is simple, sensitive and precise; it can be used for the routine quality control testing of marketed formulations.DOI: http://dx.doi.org/10.3329/icpj.v1i10.11852 International Current Pharmaceutical Journal 2012, 1(10): 332-335
The Ranks of the Homotopy Groups of a Finite Dimensional Complex
Authors: Félix Yves , Halperin Steve , Thomas Jean-Claude 
Published: September 2012

AbstractLet X be an n-dimensional, finite, simply connected CWcomplex and setWhen 0 < αX < ∞, we give upper and lower bounds for for k sufficiently large. We also show for any r that αX can be estimated from the integers rk πi (X), i ≤ nr with an error bound depending explicitly on r.
Patrón de dieta de la población púnic de Can Marines (Ibiza) a través del análisis de isótopos estables (C y N) en colágeno óseo
Authors: Salazar García Domingo Carlos 
Published: September 2012

Se presenta aquí los resultados de análisis de isótopos estables del carbono y del nitrógeno en colágeno óseo de humanos del yacimiento Púnico de Can Marines (ss. V-IV aC) de la isla de Ibiza (España). Hasta la fecha, hay pocos estudios isotópicos para este periodo en el Mediterráneo. Este artículo presenta nuevos datos isotópicos de un yacimiento púnico rural del Mediterráneo Occidental. Los resultados muestran una dieta basada en recursos terrestres sin evidencia isotópica del consumo proteico de recursos acuáticos, y sugieren la presencia de recursos C4 en ella.
Terracotas púnicas representando a mujeres: nuevos códigos de lectura para su interpretación
Authors: López-Bertrán Mireia , Aranegui Gascó Carmen 
Published: September 2012

Desde los años 1990 la arqueología y la antropología se han interesado por la teoría del embodiment. Este artículo analiza algunas terracotas femeninas de los cementerios púnicos del Puig des Molins (Eivissa) y Cartago (Túnez) (siglos VI-II a.C.) a partir de la hipótesis de que representan a mujeres reales que tuvieron un papel central en los rituales funerarios, en tanto que intérpretes de música, bailarinas o plañideras. Sostiene que estas mujeres mostraban su estatus y poder a través de sus cuerpos (embodiment), profusamente engalanados con tocados y alhajas que las hacen visibles socialmente.
Physical, Sexual, and Intimate Partner Violence Among Transgender and Gender-Diverse Individuals
Authors: Closson Kalysha , Boyce Sabrina C. , Johns Nicole , Inwards-Breland David J. , Thomas Edwin Elizabeth , Raj Anita 
Published: June 2024

ImportanceTransgender and gender-diverse (TGD) communities experience disproportionate levels of violence, yet due to limitations in measuring TGD identity, few state-representative estimates are available.ObjectiveTo assess gender identity differences in experiences of violence among adults.Design, Setting, and ParticipantsCross-sectional data from the 2023 California Violence Experiences (CalVEX) survey, weighted to provide state-representative estimates, was used to assess associations between gender identity and past-year experiences of violence among adults 18 years and older. Data were analyzed from June to December 2023.ExposureGender identity (cisgender women, cisgender men, transgender women, transgender men, and nonbinary individuals).Main Outcomes and MeasuresExperience of physical violence (including physical abuse and threat or use of a weapon), sexual violence (verbal sexual harassment, homophobic or transphobic slurs, cyber and physically aggressive sexual harassment, and forced sex), and intimate partner violence (IPV; emotional, physical, or sexual violence) using age-adjusted logistic regression.ResultsIn total 3560 individuals (weighted cumulative response rate, 5%) completed the 2023 CalVEX survey, with 1978 cisgender women, 1431 cisgender men, 35 transgender women, 52 transgender men, and 64 nonbinary respondents (mean [SD] age, 47.1 [17.5] years; 635 [17%] were Asian, 839 [37%] were Hispanic, and 1159 [37%] were White). Past-year physical violence was reported by 22 transgender men (43%), 9 transgender women (24%), and 9 nonbinary respondents (14%). Past-year sexual violence was reported by 23 transgender men (42%), 11 transgender women (14%), and 31 nonbinary respondents (56%). Compared with cisgender women, transgender women and transgender men had greater risk of past-year physical violence (any form) (transgender women adjusted incidence rate ratio [AIRR], 6.7; 95% CI, 2.5-18.2; transgender men AIRR, 9.7; 95% CI, 5.3-17.7), as well as past-year IPV (any form) (transgender women AIRR, 3.2; 95% CI, 1.3-8.0; transgender men AIRR, 6.7; 95% CI, 4.0-11.3). Relative to cisgender women, transgender men (AIRR, 3.0; 95% CI, 1.7-5.1) and nonbinary respondents (AIRR, 3.3; 95% CI, 2.1-5.2) had greater risk of past-year sexual violence (any form).Conclusions and RelevanceIn this survey study of adults in California, results showed that TGD individuals, especially transgender men, are at higher risk of experiencing all forms of violence relative to cisgender women. Results highlight the need for gender-affirming violence prevention and intervention services as well as policies that protect TGD individuals from discriminatory violence.
The effect of Inc parameter on VMAT radiotherapy plans quality for rectal cancer using Monaco TPS
Authors: Zhou Peng , Luo Jia , Su Xiaona , Chen Chuan 
Published: June 2024

AbstractBackgroundTo investigate the effect of the Increment of gantry angle (Inc) parameter setting of the Monaco Treatment planning system (Monaco TPS) on the dosimetry and quality parameters of the volumetric modulated arc therapy (VMAT) program for rectal cancer.MethodsA retrospective analysis was conducted on 50 patients with rectal cancer who underwent intensity modulated radiation therapy using the Monaco TPS system from 2020 to 2021. Under the same optimization function configuration and other parameter settings, the Inc parameters in the VMAT radiotherapy plan were set to 10°, 20°, 30°, and 40°. The dose‐volume histogram (DVH) was used to evaluate the dose distribution of the target area and the radiation dose of the organs at risk (OAR). The differences in the dosimetry of the planning target volume (PTV) and OAR, as well as the gamma pass rate (GPR) were compared.ResultsIn terms of target dose, D98, Dmin, HI, and conformity index (CI) of Inc10 group was significantly lower than those of Inc20, 30, and 40 groups (P < 0.05), and D2 of Inc10 group was significantly higher than that of Inc20 group (P = 0.009). We also found CI of Inc20 and 30 were significantly better than that of Inc40 (both P < 0.05). In terms of OAR dose, the study found that the Dmean, Dmin, V50%, V45%, and V40% for the bladder of the Inc10 group were lower than those of the other groups (all P < 0.05), the Dmean for femoral head of the Inc20 group was lower than that of the Inc30 group (P < 0.05), and Inc20 showed a better protective effect on the femoral head. The MUs tend to decrease as the Inc parameter setting is increased. The monitor unit (MU) in Inc10 group were significantly higher than those in Inc20, Inc30, and Inc40 groups, and the MU of Inc20 group was significantly higher than that of Inc40 group (both P < 0.05). We found that for the 3%/3 mm and 2%/2 mm standards, the GPRs of each plan were > 90%, which met clinical requirements.ConclusionsDifferent settings of Inc parameters have varying degrees of impact on target dose, OAR dose, and machine MU. It is important for doctors to choose different Inc parameters according to different clinical needs.
Dose conformity and falloff in single‐lesion intracranial SRS with DCA and VMAT methods
Authors: Kuperman Vadim Y. , Altundal Yücel , Kandel Sunil , Kouskoulas Tamara N. 
Published: June 2024

AbstractBackgroundIntracranial stereotactic radiosurgery (SRS) aims at achieving highly conformal dose distribution and, at the same time, attaining rapid dose falloff outside the treatment target. SRS is performed using different techniques including dynamic conformal arcs (DCA) and volumetric modulated arc therapy (VMAT).PurposeIn this study, we compare dose conformity and falloff in DCA and VMAT plans for SRS with a single target.MethodsTo compare dose conformity in SRS plans, we employ a novel conformity index , RTOG conformity index (), and Riet‐Paddick conformity index (). In addition, we use indices , , and to evaluate dose falloff. For each of the considered 118 cases of SRS, two plans were created using DCA and VMAT. A two‐tailed Student's t‐test was used to evaluate the difference between the employed indices for the DCA and VMAT plans.ResultsThe studied VMAT plans were characterized by higher dose conformity than the DCA plans. The differences between the conformity indices for the DCA plans and VMAT plans were statistically significant. The DCA plans had a smaller number of monitor units (MUs) and smaller indices R50%, V10Gy, and V12Gy than the VMAT plans. However, the differences between R50%, V10Gy, and V12Gy for the DCA and VMAT plans were not statistically significant.ConclusionsAlthough the studied VMAT plans had higher dose conformity, they also had larger MUs than the DCA plans. In terms of dose falloff characterized by parameters R50%, V10Gy, and V12Gy, DCA serves as a reasonable alternative to VMAT in the case of a single brain metastasis.
Utility value is key. Exploring factors that contribute to student motivation for effective cognitive learning strategies in higher education
Authors: Broeren Marloes , Verkoeijen Peter , Arends Lidia , Smeets Guus 
Published: June 2024

AbstractEffective cognitive learning strategies are beneficial for learning and long‐term retention. However, higher education students often rely on surface‐level strategies like reading and underlining. Interventions to support effective cognitive strategy use have addressed knowledge, beliefs, planning, and commitment. This latter aspect and its relation with motivation has remained underexposed. Therefore, this study aimed to answer the following research question: What factors contribute to student motivation for effective cognitive strategy use during self‐study in higher education? First‐year vocational university students participated in focus group discussions (N = 100), and completed a strategy questionnaire (N = 217). Results showed that students used combinations of effective cognitive and surface‐level strategies based on successful past experiences. Perceived utility value of strategies for students' performance‐oriented goals contributed considerably to motivation, and students reduced perceived costs by combining self‐study with non‐academic activities. Incorporating these aspects in strategy support could be next steps for future interventions.
How Does Osteoarthritis Education Influence Knowledge, Beliefs, and Behavior in People With Knee and Hip Osteoarthritis? A Systematic Review
Authors: Simick Behera Naomi , Duong Vicky , Eyles Jillian , Cui Haoze , Gould Daniel , Barton Christian , Belton Joletta , Hunter David , Bunzli Samantha 
Published: June 2024

ObjectiveOur goal was to inform the design and implementation of osteoarthritis (OA) education for people with knee and hip OA. This review investigated the impact of OA education on knowledge, beliefs, and behavior and how and why these changes occur.MethodsFive databases—MEDLINE, Excerpta Medica Database (Embase), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Scopus, Physiotherapy Evidence Database (PEDro)—were searched in August 2023. Eligible studies were quantitative, qualitative, and mixed‐methods, involving OA education interventions and assessing knowledge, beliefs, and/or behavioral outcomes. An interpretivist analytic process guided data evaluation, synthesis, and description of meta‐themes.ResultsNinety‐eight studies were included (80 quantitative, 12 qualitative, 6 mixed‐methods). OA education was heterogeneous in content and delivery. Outcome measures varied, with poor distinction among knowledge, beliefs, and behavior constructs. Trends toward short‐term knowledge improvement were observed, but there were no clear trends in beliefs or behavior change. Intrinsic factors (eg, pre‐existing beliefs) and extrinsic factors (eg, socioeconomic factors) appeared to influence change. Three meta‐themes described how and why changes may occur: (i) engagement: how individuals relate with education content and delivery; (ii) embodiment: the role of experiential factors in learning, and (iii) empowerment: the level of agency education generates.ConclusionBeyond the provision of information and instruction, OA education is a complex, relational process influenced by multidimensional factors. This review identifies potentially important strategies at individual, interpersonal, and community levels to support the design and delivery of engaging education that promotes holistic, embodied learning and facilitates meaningful, empowering change.image
Output tracking for a flexible string system with unknown harmonic disturbances using adaptive internal model
Authors: Peng Ning , Liu Jun‐Jun , Peng Xiao 
Published: June 2024

AbstractA non‐collocated output tracking problem for a flexible string with tip payload at one end was studied in this paper, which is expected to describe by a wave equation coupled ordinary differential equation (ODE) system. The regulated output and the reference trajectory signal with unknown frequency and amplitude are non‐collocated with the boundary control input. An adaptive approach has been developed to determine the unknown frequency of a disturbance by constituting an auxiliary trajectory and an internal model structure. In order to regulate exponential output tracking, the proposed error‐based adaptive dynamic compensation controller is employed. Closed‐loop stability and well‐posedness is established by exploiting the principle of semigroup theory. Finally, simulation experiments are performed to show the proposed scheme is very effective.
Intelligent Soft Quasi‐Organism Equipped with Sensor‐Driven Integrated Tentacles
Authors: Liu Chang , Luo Jinan , Liu Haidong , Fu Junxin , Liu Houfang , Tang Hao , Deng Zhikang , Wu Jingzhi , Li Yuanfang , Liu Chuting , Peng Shiqi , Hu Juxin , Ren Tian‐Ling , Zhou Jianhua , Qiao Yancong 
Published: June 2024

AbstractIntegration of soft electronic system components is critical to create a closed‐loop system that seamlessly integrates sensing, driving, processing, and autonomous control capabilities. However, the existence of these components, particularly sensors and actuators, in isolated or discrete forms complicates the endeavor to achieve seamless interface matching and in situ integration, no more than the autonomic system. Here, an intelligent soft quasi‐organism (SQO) equipped with sensor‐driven integrated tentacles is demonstrated, featuring real‐time state recognition and autonomous object recognition inspired by the sea anemones. By employing a heterogeneous mechanisms homotopic integration (HMHI) strategy, the tentacles of the SQO possess the unique ability to simultaneously perceive state changes and flexibly drive motions, utilizing the same material and structure. The sea anemone‐shaped SQO exhibits real‐time autonomous state identification capabilities through the integration of machine learning and customized circuits, attaining 100% recognition accuracy across sixteen states. With a neuromuscular system that facilitates active autonomous perception, the anemone‐shaped SQO can recognize and intelligently grasp static objects with an accuracy of 80.7%, surpassing that of a human hand (74.7%). The SQO provides a promising approach for realizing artificial neuromuscular systems, with great potential for applications in crucial areas such as intelligent soft robotics and in vivo therapy.
A Dual Enhancing Strategy of Novel Nanovaccine Based on TIM3 Silencing Nanoadjuvants and Desialylated Cancer Cell Membrane Antigens for Personalized Vaccination Immunotherapy of Cancer
Authors: Li Kaiming , Li Xiaolin , Wu Jie , Wu Haisi , Wu Min , Zhou Yupeng , Lin Ya , Zou Yifan , Jiang Xiqun , Xu Huae 
Published: June 2024

AbstractCancer vaccines represent a promising form of immunotherapy employed in the treatment of cancer. However, their efficiency in eliciting immune responses is limited, and satisfactory results have yet to be achieved. Optimizing adjuvants and antigens is an important approach to promoting the anti‐tumor efficacy of cancer vaccines. Here, a novel nanoadjuvant (LNP/siRNA) designed to silence T‐cell immunoglobulin and mucin‐domain containing‐3 (TIM3) and activate Toll‐like receptors (TLRs) is presented. The LNP/siRNA demonstrates significant potential in promoting dendritic cell (DC) maturation and enhancing the anti‐tumor response. Furthermore, desialylated cancer cell membrane is utilized as antigens, providing a variety of tumor antigens for DCs and enhancing their function. Additionally, they are integrated to create a core‐shell structured nanovaccine (dClip‐LNP/siRNA) through coextrusion, which collectively enhances the cross‐presentation ability of DCs, thus achieving a dual enhancement strategy. The dClip‐LNP/siRNA significantly silences TIM3 expression in DCs and promotes antigen presentation by DCs. Besides, dClip‐LNP/siRNA significantly promotes the activation of T cells in lymph nodes and induces robust and durable anti‐tumor immunity in tumor sites to eliminate established B16‐OVA tumors, prevent tumor occurrence, and suppress tumor lung metastasis. The dClip‐LNP/siRNA is also suitable for combination with adoptive OT‐I cell therapy to enhance cancer immunotherapy. The dClip‐LNP/siRNA represents a robust vaccine platform for personalized cancer immunotherapy.
Surface Engineering for Endothelium‐Mimicking Functions to Combat Infection and Thrombosis in Extracorporeal Life Support Technologies
Authors: Ashcraft Morgan , Garren Mark , Lautner‐Csorba Orsolya , Pinon Vicente , Wu Yi , Crowley Dagney , Hill Joseph , Morales Yeniselis , Bartlett Robert , Brisbois Elizabeth J. , Handa Hitesh 
Published: June 2024

AbstractBlood‐contacting medical devices routinely fail from the cascading effects of biofouling toward infection and thrombosis. Nitric oxide (NO) is an integral part of endothelial homeostasis, maintaining platelet quiescence and facilitating oxidative/nitrosative stress against pathogens. Recently, it is shown that the surface evolution of NO can mediate cell‐surface interactions. However, this technique alone cannot prevent the biofouling inherent in device failure with dynamic blood‐contacting applications. This work proposes an endothelium‐mimicking surface design pairing controlled NO release with an inherently antifouling polyethylene glycol interface (NO+PEG). This simple, robust, and scalable platform develops surface‐localized NO availability with surface hydration, leading to a significant reduction in protein adsorption as well as bacteria/platelet adhesion. Further in vivo thrombogenicity studies show a decrease in thrombus formation on NO+PEG interfaces, with preservation of circulating platelet and white blood cell counts, maintenance of activated clotting time, and reduced coagulation cascade activation. It is anticipated that this bio‐inspired surface design will enable a facile alternative to existing surface technologies to address clinical manifestations of infection and thrombosis in dynamic blood‐contacting environments.
Toward Functionality and Deactivation of Metal‐Single‐Atom in Heterogeneous Photocatalysts
Authors: Cheng Lei , Wu Qiaolin , Sun Hanjun , Tang Yawen , Xiang Quanjun 
Published: June 2024

AbstractSingle‐atom heterogeneous catalysts (SAHCs) provide an enticing platform for understanding catalyst structure–property–performance relationships. The 100% atom utilization and adjustable local coordination configurations make it easy to probe reaction mechanisms at the atomic level. However, the progressive deactivation of metal‐single‐atom (MSA) with high surface energy leads to frequent limitations on their commercial viability. This review focuses on the atomistic‐sensitive reactivity and atomistic‐progressive deactivation of MSA to provide a unifying framework for specific functionality and potential deactivation drivers of MSA, thereby bridging function, purpose‐modification structure–performance insights with the atomistic‐progressive deactivation for sustainable structure–property–performance accessibility. The dominant functionalization of atomically precise MSA acting on properties and reactivity encompassing precise photocatalytic reactions is first systematically explored. Afterward, a detailed analysis of various deactivation modes of MSA and strategies to enhance their durability is presented, providing valuable insights into the design of SAHCs with deactivation‐resistant stability. Finally, the remaining challenges and future perspectives of SAHCs toward industrialization, anticipating shedding some light on the next stage of atom‐economic chemical/energy transformations are presented.