bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of Children With BCR-ABL1–Like Acute Lymphoblastic Leukemia Treated With Risk-Directed Therapy Based on the Levels of Minimal Residual Disease
Authors: Roberts Kathryn G. , Pei Deqing , Campana Dario , Payne-Turner Debbie , Li Yongjin , Cheng Cheng , Sandlund John T. , Jeha Sima , Easton John , Becksfort Jared , Zhang Jinghui , Coustan-Smith Elaine , Raimondi Susana C. , Leung Wing H. , Relling Mary V. , Evans William E. , Downing James R. , Mullighan Charles G. , Pui Ching-Hon 
Published: July 2014

Purpose BCR-ABL1–like acute lymphoblastic leukemia (ALL) is a recently identified B-cell ALL (B-ALL) subtype with poor outcome that exhibits a gene expression profile similar to BCR-ABL1-positive ALL but lacks the BCR-ABL1 fusion protein. We examined the outcome of children with BCR-ABL1–like ALL treated with risk-directed therapy based on minimal residual disease (MRD) levels during remission induction. Patients and Methods Among 422 patients with B-ALL enrolled onto the Total Therapy XV study between 2000 and 2007, 344 had adequate samples for gene expression profiling. Next-generation sequencing and/or analysis of genes known to be altered in B-ALL were performed in patients with BCR-ABL1–like ALL who had available material. Outcome was compared between patients with and those without BCR-ABL1–like ALL. Results Forty (11.6%) of the 344 patients had BCR-ABL1–like ALL. They were significantly more likely to be male, have Down syndrome, and have higher MRD levels on day 19 and at the end of induction than did other patients with B-ALL. Among 25 patients comprehensively studied for genetic abnormalities, 11 harbored a genomic rearrangement of CRLF2, six had fusion transcripts responsive to ABL tyrosine kinase inhibitors or JAK inhibitors, and seven had mutations involving the Ras signaling pathway. There were no significant differences in event-free survival (90.0% ± 4.7% [SE] v 88.4% ± 1.9% at 5 years; P = .41) or in overall survival (92.5% ± 4.2% v 95.1% ± 1.3% at 5 years; P = .41) between patients with and without BCR-ABL1–like ALL. Conclusion Patients who have BCR-ABL1–like ALL with poor initial treatment response can be salvaged with MRD-based risk-directed therapy and may benefit from identification of kinase-activating lesions for targeted therapies.
Entering the Era of Targeted Therapy for Chronic Lymphocytic Leukemia: Impact on the Practicing Clinician
Authors: Byrd John C. , Jones Jeffrey J. , Woyach Jennifer A. , Johnson Amy J. , Flynn Joseph M. 
Published: July 2014

Purpose Chemoimmunotherapy has been the standard of care for chronic lymphocytic leukemia (CLL). However, the introduction of B-cell receptor (BCR) kinase inhibitors such as ibrutinib has the potential to eliminate the role of chemotherapy in the treatment of CLL. How to best incorporate old and new therapies for CLL in this landscape is increasingly complex. Methods This article reviews current data available to clinicians and integrates these data to provide a strategy that can be used to approach the treatment of CLL in the era of BCR signaling inhibitors. Results Current strategies separate patients based on age or functional status as well as genetics [presence or absence of del(17)(p13.1)]. In the era of targeted therapy, this will likely continue based on current available data. Phase III studies support chemoimmunotherapy as the initial standard therapy for patients without del(17)(p13.1). Choice of chemotherapy (fludarabine plus cyclophosphamide, bendamustine, or chlorambucil) and anti-CD20 antibody (rituximab, ofatumumab, or obinutuzumab) varies based on regimen and patient status. For patients with del(17)(p13.1), no standard initial therapy exists, although several options supported by phase II clinical trials (methylprednisolone plus alemtuzumab or ibrutinib) seem better than chemoimmunotherapy. Treatment of relapsed CLL seems to be best supported by ibrutinib-based therapy. Completion of trials with ibrutinib and other new agents in the near future will offer opportunity for chemotherapy-free treatment across all groups of CLL. Conclusion Therapy for CLL has evolved significantly over the past decade with introduction of targeted therapy for CLL. This has the potential to completely transform how CLL is treated in the future.
Oncology Fellows' Career Plans, Expectations, and Well-Being: Do Fellows Know What They Are Getting Into?
Authors: Shanafelt Tait D. , Raymond Marilyn , Horn Leora , Moynihan Tim , Collichio Frances , Chew Helen , Kosty Michael P. , Satele Daniel , Sloan Jeff , Gradishar William J. 
Published: July 2014

Purpose To evaluate the career plans, professional expectations, and well-being of oncology fellows compared with actual experiences of practicing oncologists. Methods US oncology fellows taking the 2013 Medical Oncology In-Training Examination (MedOnc ITE) were invited to participate in an optional postexamination survey. The survey evaluated fellows' career plans and professional expectations and measured burnout, quality of life (QOL), fatigue, and satisfaction with work-life balance (WLB) using standardized instruments. Fellows' professional expectations and well-being were compared with actual experiences of US oncologists assessed simultaneously. Results Of the 1,637 oncology fellows in the United States, 1,373 (83.9%) took the 2013 MedOnc ITE. Among these, 1,345 (97.9%) completed the postexamination survey. The frequency of burnout among fellows decreased from 43.3% in year 1 to 31.7% in year 2 and 28.1% in year 3 (P < .001). Overall, the rate of burnout among fellows and practicing oncologists was similar (34.1% v 33.7%; P = .86). With respect to other dimensions of well-being, practicing oncologists had lower fatigue (P < .001) and better overall QOL scores (P < .001) than fellows but were less satisfied with WLB (P = .0031) and specialty choice (P < .001). Fellows' expectations regarding future work hours were 5 to 6 hours per week fewer than oncologists' actual reported work hours. Levels of burnout (P = .02) and educational debt (P ≤ .004) were inversely associated with ITE scores. Fellows with greater educational debt were more likely to pursue private practice and less likely to plan an academic career. Conclusion Oncology fellows entering practice trade one set of challenges for another. Unrealized expectations regarding work hours may contribute to future professional dissatisfaction, burnout, and challenges with WLB.
Early-Onset Type 2 Diabetes Impairs Skeletal Acquisition in the Male TALLYHO/JngJ Mouse
Authors: Devlin M. J. , Van Vliet M. , Motyl K. , Karim L. , Brooks D. J. , Louis L. , Conlon C. , Rosen C. J. , Bouxsein M. L. 
Published: July 2014

AbstractType 2 diabetes (T2D) incidence in adolescents is rising and may interfere with peak bone mass acquisition. We tested the effects of early-onset T2D on bone mass, microarchitecture, and strength in the TALLYHO/JngJ mouse, which develops T2D by 8 weeks of age. We assessed metabolism and skeletal acquisition in male TALLYHO/JngJ and SWR/J controls (n = 8–10/group) from 4 weeks to 8 and 17 weeks of age. Tallyho mice were obese; had an approximately 2-fold higher leptin and percentage body fat; and had lower bone mineral density vs SWR at all time points (P &lt; .03 for all). Tallyho had severe deficits in distal femur trabecular bone volume fraction (−54%), trabecular number (−27%), and connectivity density (−82%) (P &lt; .01 for all). Bone formation was higher in Tallyho mice at 8 weeks but lower by 17 weeks of age vs SWR despite similar numbers of osteoblasts. Bone marrow adiposity was 7- to 50-fold higher in Tallyho vs SWR. In vitro, primary bone marrow stromal cell differentiation into osteoblast and adipocyte lineages was similar in SWR and Tallyho, suggesting skeletal deficits were not due to intrinsic defects in Tallyho bone-forming cells. These data suggest the Tallyho mouse might be a useful model to study the skeletal effects of adolescent T2D.
Overexpression of PPARγ Specifically in Pancreatic β-Cells Exacerbates Obesity-Induced Glucose Intolerance, Reduces β-Cell Mass, and Alters Islet Lipid Metabolism in Male Mice
Authors: Hogh K-Lynn N. , Craig Michael N. , Uy Christopher E. , Nygren Heli , Asadi Ali , Speck Madeline , Fraser Jordie D. , Rudecki Alexander P. , Baker Robert K. , Orešič Matej , Gray Sarah L. 
Published: July 2014

Abstract
The contribution of peroxisomal proliferator-activated receptor (PPAR)-γ agonism in pancreatic β-cells to the antidiabetic actions of thiazolidinediones has not been clearly elucidated. Genetic models of pancreatic β-cell PPARγ ablation have revealed a potential role for PPARγ in β-cell expansion in obesity but a limited role in normal β-cell physiology. Here we overexpressed PPARγ1 or PPARγ2 specifically in pancreatic β-cells of mice subjected to high-fat feeding using an associated adenovirus (β-PPARγ1-HFD and β-PPARγ2-HFD mice). We show β-cell-specific PPARγ1 or PPARγ2 overexpression in diet-induced obese mice exacerbated obesity-induced glucose intolerance with decreased β-cell mass, increased islet cell apoptosis, and decreased plasma insulin compared with obese control mice (β-eGFP-HFD mice). Analysis of islet lipid composition in β-PPARγ2-HFD mice revealed no significant changes in islet triglyceride content and an increase in only one of eight ceramide species measured. Interestingly β-PPARγ2-HFD islets had significantly lower levels of lysophosphatidylcholines, lipid species shown to enhance insulin secretion in β-cells. Gene expression profiling revealed increased expression of uncoupling protein 2 and genes involved in fatty acid transport and β-oxidation. In summary, transgenic overexpression of PPARγ in β-cells in diet-induced obesity negatively impacts whole-animal carbohydrate metabolism associated with altered islet lipid content, increased expression of β-oxidative genes, and reduced β-cell mass.
Ezrin is an Actin Binding Protein That Regulates Sertoli Cell and Spermatid Adhesion During Spermatogenesis
Authors: Gungor-Ordueri N. Ece , Tang Elizabeth I. , Celik-Ozenci Ciler , Cheng C. Yan 
Published: July 2014

AbstractDuring spermatogenesis, the transport of spermatids and the release of sperms at spermiation and the remodeling of the blood-testis barrier (BTB) in the seminiferous epithelium of rat testes require rapid reorganization of the actin-based cytoskeleton. However, the mechanism(s) and the regulatory molecule(s) remain unexplored. Herein we report findings that unfold the functional significance of ezrin in the organization of the testis-specific adherens junction at the spermatid-Sertoli cell interface called apical ectoplasmic specialization (ES) in the adluminal compartment and the Sertoli cell-cell interface known as basal ES at the BTB. Ezrin is expressed at the basal ES/BTB in all stages, except from late VIII to IX, of the epithelial cycle. Its knockdown by RNA interference (RNAi) in vitro perturbs the Sertoli cell tight junction-permeability barrier via a disruption of the actin microfilaments in Sertoli cells, which in turn impeded basal ES protein (eg, N-cadherin) distribution, perturbing the BTB function. These findings were confirmed by a knockdown study in vivo. However, the expression of ezrin at the apical ES is restricted to stage VIII of the cycle and limited only between step 19 spermatids and Sertoli cells. A knockdown of ezrin in vivo by RNAi was found to impede spermatid transport, causing defects in spermiation in which spermatids were embedded deep inside the epithelium, and associated with a loss of spermatid polarity. Also, ezrin was associated with residual bodies and phagosomes, and its knockdown by RNAi in the testis also impeded the transport of residual bodies/phagosomes from the apical to the basal compartment. In summary, ezrin is involved in regulating actin microfilament organization at the ES in rat testes.
Immunoglobulin Heavy Chain Variable Region and Major Histocompatibility Region Genes Are Linked to Induced Graves' Disease in Females From Two Very Large Families of Recombinant Inbred Mice
Authors: McLachlan Sandra M. , Aliesky Holly , Banuelos Bianca , Magana Jessica , Williams Robert W. , Rapoport Basil 
Published: July 2014

AbstractGraves' hyperthyroidism is caused by antibodies to the TSH receptor (TSHR) that mimic thyroid stimulation by TSH. Stimulating TSHR antibodies and hyperthyroidism can be induced by immunizing mice with adenovirus expressing the human TSHR A-subunit. Prior analysis of induced Graves' disease in small families of recombinant inbred (RI) female mice demonstrated strong genetic control but did not resolve trait loci for TSHR antibodies or elevated serum T4. We investigated the genetic basis for induced Graves' disease in female mice of two large RI families and combined data with earlier findings to provide phenotypes for 178 genotypes. TSHR antibodies measured by inhibition of TSH binding to its receptor were highly significantly linked in the BXD set to the major histocompatibility region (chromosome 17), consistent with observations in 3 other RI families. In the LXS family, we detected linkage between T4 levels after TSHR-adenovirus immunization and the Ig heavy chain variable region (Igvh, chromosome 12). This observation is a key finding because components of the antigen binding region of Igs determine antibody specificity and have been previously linked to induced thyroid-stimulating antibodies. Data from the LXS family provide the first evidence in mice of a direct link between induced hyperthyroidism and Igvh genes. A role for major histocompatibility genes has now been established for genetic susceptibility to Graves' disease in both humans and mice. Future studies using arrays incorporating variation in the complex human Ig gene locus will be necessary to determine whether Igvh genes are also linked to Graves' disease in humans.
Inhomogeneous Deactivation with UV Excitation in Submicron Grains of Lead Iodide Perovskite-based Solar Cell as Revealed by Femtosecond Transient Absorption Microscopy
Authors: Katayama Tetsuro , Jinno Akira , Takeuchi Eisuke , Ito Syoji , Endo Masaru , Wakamiya Atsushi , Murata Yasujiro , Ogomi Yuhei , Hayase Shuji , Miyasaka Hiroshi 
Published: July 2014

Abstract
Femtosecond transient absorption microscopy was applied to the elucidation of ultrafast dynamics in a lead iodide perovskite solar cell. Space- and time-resolved detection revealed that rapid deactivation with a time constant of 0.7 ps took place without long-living species in submicron grains with the (CH3NH3)PbI3 capping layer, while the long-living component was detected in other areas.
Eco-efficient, Chemoselective, and Rapid Access to Aminals from Lactams Using Recyclable Silica-supported FeCl3 Catalyst in Green Solvent
Authors: Ramachandran Gunasekar , Mandlimath Triveni Rajashekhar , Sathesh Venkatesan , Umamahesh Balijapalli , Sathiyanarayanan Kulathu I 
Published: July 2014

Abstract
A highly efficient and environmentally benign protocol was developed for the synthesis of aminals using silica-supported iron(III) chloride as an active Lewis acid recyclable heterogeneous catalyst from N-nucleophiles and active carboxaldehydes. This current modest protocol is cost-effective and an environmentally benign method for the synthesis of pharmaceutically and industrially useful scaffolds.
Kimpul (Xanthosoma spp.) characterization based on morphological characteristic and isozymic analysis
Authors: NURMIYATI NURMIYATI , SUGIYARTO SUGIYARTO , SAJIDAN SAJIDAN 
Published: July 2014

Abstract. Nurmiyati, Sugiyarto, Sajidan. 2009. Kimpul (Xanthosoma spp.) characterization based on morphological characteristic and isozymic analysis. Nusantara Bioscience 1: 138-145. This research is aimed: (i) to know the variety of kimpul (Xanthosoma spp.) based on morphological characteristics and isozymes analysis; (ii) to know the correlation between its genetic space based on morphological characteristics and its genetic resemblance based on isozymes-banding pattern. These research results were analyzed and described by descriptive qualitative methods. Morphological observation was carried out in sub-District of Galur, Lendah, and Girimulyo, Kulonprogo District, Yogyakarta. Morphological data of the kimpul plant was explored descriptively and then made dendrogram. Data of isozymic banding pattern were analyzed quantitatively based on the appearance of the band on the gel, and qualitatively based on the thickness of the band formed, and then made dendrogram. The correlation, between its genetic distance based on morphological characteristics and its genetic resemblance based on isozymes-banding pattern, were then analyzed grounded on coefficient correlation between product-moment and goodness of it criteria based on correlation. The results pointed out that morphologically, on eight observed samples which were consist of four different types (species), each Xanthosoma from different locations did not indicate obvious differences. Esterase was formed four different banding-patterns, Glutamate Oxaloacetate Transaminase indicated eight different banding-patterns, and Peroxidase indicated seven different banding-patterns. Correlation between morphological data and data from EST and GOT isozymic banding pattern was very good (0.967918 and 0.937113), While, the correlations between morphological data and POD isozymes were good (0.892721).
goodnessÂ of itÂ criteriaÂ based onÂ correlation.Â The results pointed outÂ thatÂ morphologically,Â on eightÂ observedÂ samples Â which were consist of four different types (species), each Xanthosoma from different locations did not indicate obvious differences. Esterase was formed four different banding- patterns, Glutamate Oxaloacetate Transaminase indicated eight different banding-patterns, and Peroxidase indicated seven different banding-patterns. Correlation between morphological data and Â data from EST and GOT isozymic banding pattern Â were very good (0.967918 and 0.937113), While, the Â orrelations between morphological data and POD isozymes were good (0.892721).
Review: Mycoendophytes in medicinal plants: Diversity and bioactivities
Authors: RAI MAHENDRA , GADE ANIKET , RATHOD DNYANESHWAR , DAR MUDASIR , VARMA AJIT 
Published: July 2014

Abstract. Rai M, Gade A, Rathod D, Dar M, Varma A. 2012. Review: Mycoendophytes in medicinal plants: Diversity and bioactivities. Nusantara Bioscience 4: 86-96. Endophytes are microorganisms that reside in internal tissues of living plants without causing any negative effect. These offer tremendous potential for the exploitation of novel and eco-friendly secondary metabolites used in medicine, the pharmaceutical industry and agriculture. The present review is focused on diversity of endophytes, current national and international bioactive secondary metabolite scenario and future prospects. Endophytic fungi as novel source of potentially useful medicinal compounds are discussed along with the need to search for new and more effective agents from endophytes to combat disease problems
Response of Silybum marianum plant to irrigation intervals combined with fertilization
Authors: HENDAWY SABER F. , HUSSEIN MOHAMED S. , YOUSSEF ABD-ELGHANI A. , EL-MERGAWI REYAD A. 
Published: July 2014

Abstract. Hendawy SF, Hussein MS, Youssef AA, El-Mergawi RA. 2013. Response of Silybum marianum plant to irrigation intervals combined with fertilization. Nusantara Bioscience 5: 22-29. This study was investigated to evaluate the influence of different kinds of organic and bio fertilization under different irrigation intervals on the growth, production and chemical constituents of Silybum marianum plant. Data indicated that all studied growth and yield characters were significantly affected by the duration of irrigation intervals. Fertilizer treatments had a primitive effect on growth and yield characters. The interaction between irrigation intervals and fertilizer treatments has a clear considerable effect on growth and yield characters. The obtained results indicated the favorable effect of organic and bio fertilizers which reduce the harmful effect of water stress. Different treatments had a pronounced effect on silymarin content.
MDGs in Nigeria, communication and the media
Authors: Udoakah Nkereuwem , Negrine Ralph 
Published: July 2014

Abstract
This article takes a look at the African perspective of the Millennium Development Goals (MDGs) and examines Nigeria’s communication strategy for its implementation. Against the backdrop of endemic corruption in Nigeria and her news commercialization policy, the article examines the extent to which the media have been mobilized or motivated to be partners in the MDGs campaign. Also, it tries to bring to the fore how the citizens have been carried along in the campaign and what roles (if any) they have been made to play.
Sources used for the data for this article include public communication and media advocacy literature, interviews with key informants with knowledge about Nigeria’s MDGs and a survey of Nigerian editors. Some information also came from the Conference on MDGs campaign organized at the University of Uyo in November 2011.
It was found that, because government media dominate the Nigerian media environment, a paternalistic relationship seems to be the expectation of the MDGs’ implementers in their dealings with the media. That is, the MDGs’ implementers tend to expect the media to go after them rather than them looking for the media. Besides, the MDGs’ implementers expect the Federal Ministry of Information and the National Orientation Agency to handle the publicity of the programmes for them. The result is that the MDGs’ campaign roadmap, which promised a behavioural change communication, has not been implemented and the attempt at the campaign lacks design and strategies. Neither are new media used for the campaign nor are the editors and journalists impressed by the awareness level about MDGs among Nigerians.
The representation of the environmental crises on Lake Victoria in Uganda’s media: A critical analysis of the Victoria Voice radio documentaries
Authors: Jjuuko Margaret , Prinsloo Jeanne 
Published: July 2014

Abstract
This article is concerned with how the environmental crises on Lake Victoria is addressed by the media in Uganda, while confining its focus on a single radio case study, and presents a critical textual analysis of the discourses and discursive practices of the Victoria Voice environmental radio documentaries aired on Uganda’s Central Broadcasting Service (CBS) radio in 2005. The analysis focuses on two representative episodes of the Victoria Voice radio series relating to the situation on Lake Victoria. It argues that the framing and construction of the situation on Lake Victoria tend to privilege the wealthy or powerful elite rather than address the root causes of environmental degradation. The marginalization of the powerless (or ordinary people) recurs in these episodes, and while their voices are included in the programmes, they are framed by the more socially powerful.
Film review
Authors: Adeleye Ifedayo 
Published: July 2014

Abstract
Tango With Me: A Step Forward with the New Nollywood Film: Tango With Me (2010). 104mins Release Date: 24 August 2012 (UK) Producer/Director: Mahmoud Ali Balogun Author: Dapo Oshiyemi Talking Drum Entertainment Stars include: Joseph Benjamin, Bimbo Manuel, Genevieve Nnaji Production Company: Brickwall Communications Production Cost: 50 Million Naira (estimated cost) Website: http://www.tangowithmefilm.com