bluuebunny/crossref_metadata_2025_split huggingface dataset:
Confined placental mosaicism at chorionic villous sampling: risk factors and pregnancy outcome
Authors: Baffero Giulia Maria , Somigliana Edgardo , Crovetto Francesca , Paffoni Alessio , Persico Nicola , Guerneri Silvana , Lalatta Faustina , Fogliani Roberto , Fedele Luigi 
Published: September 2012

ABSTRACTObjectiveThis study aims to investigate the clinical relevance of confined placental mosaicism (CPM) detected at chorionic villous sampling (CVS) and to identify risk factors for this condition.MethodWomen diagnosed with CPM between January 2005 and December 2009 were identified. They were matched to women with unremarkable CVS in a 1 : 2 ratio by study period and contacted by phone for interview.ResultsOne hundred fifteen exposed and 230 unexposed women were selected. Baseline characteristics did not differ between the study groups apart from maternal body mass index, which is mildly higher in the CPM group (+0.6 kg/m2, p = 0.047), and maternal age, which is higher in women with type III CPM (39.7 ± 2.6 vs 37.1 ± 3.2 years, p = 0.005). A higher frequency of gestational hypertension was observed in exposed women (10% vs 2%) (p = 0.003). Small for gestational age newborns were more frequent in women with type I CPM (15% vs 5%, p = 0.03). The incidence of other main complications of pregnancy (stillbirth, prematurity, preeclampsia and gestational diabetes mellitus) was similar. Neonatal complications and subsequent infant health and development did not also differ.ConclusionWomen with the diagnosis of CPM at CVS can be generally reassured regarding the course of pregnancy and infant health and development. © 2012 John Wiley & Sons, Ltd.
Is spontaneous reporting always the most important information supporting drug withdrawals for pharmacovigilance reasons in France?
Authors: Paludetto Marie‐Noelle , Olivier‐Abbal Pascale , Montastruc Jean‐Louis 
Published: September 2012

ABSTRACTPurposeThe objective of our study was to determine the nature of scientific evidence leading to drug withdrawal for safety reasons in France (between 2005 and 2011).MethodsDrugs (i.e., active ingredients) withdrawn were identified from the Web site of the French Health Products Agency. Additional information allowed us to classify these withdrawals according to the nature of evidence as clinical trials (CT), case reports/case series (CR/CS), case–control studies (CC), cohort, animal, or observational studies.ResultsA total of 22 active ingredients were withdrawn from the French market between 2005 and 2011. The nature and type of adverse drug reactions (ADRs) leading more frequently to drug withdrawal were cardiovascular (10‐fold), neurological (5‐fold), or hepatic, cutaneous, or psychiatric (3‐fold each) ADRs. CR (19/22; 86.4%) and CT (13/22; 59.1%) were the most frequently involved methods. In 5 of 22 (23%) cases, CR were the sole evidence. However, 68% (15/22) of regulatory decisions were based on multiple sources of evidence: For example, data from CR + CT were used in eight cases. CC or cohort studies were used in only five cases.ConclusionThis study underlines that spontaneous reporting remained the most important source of drug withdrawals between 2005 and 2011. However, its relative importance decreased in comparison with that in 1997–2004. The importance of pharmacoepidemiological methods slightly increased but remained low. Finally, regulatory authorities seem to have more frequently based their safety decisions on multiple sources of evidence than before. Copyright © 2012 John Wiley & Sons, Ltd.
Compressive‐shear adhesion characterization of polyvinyl‐butyral and ethylene‐vinyl acetate at different curing times before and after exposure to damp‐heat conditions
Authors: Chapuis Valentin , Pélisset Ségolène , Raeis‐Barnéoud Marylène , Li Heng‐Yu , Ballif Christophe , Perret‐Aebi Laure‐Emmanuelle 
Published: September 2012

ABSTRACTPhotovoltaic (PV) module efficiency and reliability are two factors that have an important impact on the final cost of the PV electricity production. It is widely accepted that a good adhesion between the encapsulant and the different substrates of a PV module is needed to ensure long‐term reliability. Several testing procedures exist that use a metric derived from the force at interface failure to characterize the adhesion. It has, however, not been demonstrated that those metrics relate directly to the interfacial adhesion (defined as the surface energy density needed to break interfacial bonds), and the obtained results usually relate to an apparent adhesion strength. In this work, we describe a new design for compressive‐shear testing of polymer layers bonded to rigid substrates. We use it to characterize real interfacial adhesion of ethylene‐vinyl acetate (EVA) and polyvinyl‐butyral (PVB) to a glass substrate before and after degradation in damp‐heat. Our results show that a peak‐force based metric is unable to capture the evolution of adhesion through degradation, and a new metric based on the elastic strain energy of the encapsulant is proposed. Moreover, we show that PVB adhesion to glass is much more affected by damp‐heat exposure where polymer saturation takes place, in comparison with the adhesion of EVA to glass. The presented characterization protocol is a powerful tool that can help in assessing the reliability of an encapsulant facing specific degradation conditions. Copyright © 2012 John Wiley & Sons, Ltd.
Some things change, some things stay the same: a longitudinal analysis of cancer caregivers' unmet supportive care needs
Authors: Girgis Afaf , Lambert Sylvie D. , McElduff Patrick , Bonevski Billie , Lecathelinais Christophe , Boyes Allison , Stacey Fiona 
Published: September 2012

AbstractObjectiveThe objective of this study was to identify caregivers' unmet needs and the psychosocial variables associated with unmet need count within the first 24 months post‐survivor diagnosis.MethodsCaregivers completed a comprehensive survey measuring the primary outcome, psychosocial variables, and demographics of interest at 6 (n = 547), 12 (n = 519), and 24 (n = 443) months post‐survivor diagnosis.ResultsAlthough prevalence of unmet needs significantly decreased over time, almost a third of caregivers still reported unmet needs at 24 months. Unmet needs were more prevalent among caregivers of lung cancer survivors, at 6 and 24 months. Top ranking unmet needs across time included ‘managing concerns about cancer coming back’, ‘reducing stress in the person with cancer's life’, ‘understanding the experience of the person with cancer’, and ‘accessible hospital parking’. At 24 months, some of the top ranking unmet needs were related to caregivers' well‐being and relationships. Increased interference in activities due to caregiving, anxiety, depression, avoidant and active coping, and out‐of‐pocket expenses was associated with reporting more unmet needs. Less involvement in caregiving roles and increased physical well‐being and social support were associated with reporting less unmet needs. For some variables (e.g. anxiety and depression), association with unmet needs strengthened over time.ConclusionsThis is the first longitudinal analysis of caregivers' unmet needs as they enter early and extended survivorship. Findings provide valuable insights into caregiver's unmet needs over time and identified a sub‐group of caregivers at risk of experiencing unmet needs, extending previous research and informing the timing and content of psychosocial services. Copyright © 2012 John Wiley & Sons, Ltd.
Two‐dimensional numerical analysis of nanoscale junctionless and conventional Double Gate MOSFETs including the effect of interfacial traps
Authors: Chebaki Elasaad , Djeffal Fayçal , Bentrcia Toufik 
Published: September 2012

AbstractThis paper deals with the immunity behavior of the junctionless DG MOSFET device against the hot carrier degradation effect. The junctionless device is highly privileged because of its easy fabrication procedure, homogeneity along the channel axe in addition to its promising electrical characteristics compared to the conventional DG MOSFET with PN junction at the source and the drain sides. As a result, we demonstrate that junctionless DG MOSFET can be a viable option to enhance the immunity performances of nanoscale CMOS‐based devices technology for nanoelectronics digital applications (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Exploring polysilicon deposition conditions through a laboratory CVD prototype
Authors: Ramos Alba , del Cañizo Carlos , Valdehita Javier , Zamorano Juan Carlos , Rodríguez Araceli , Luque Antonio 
Published: September 2012

AbstractCost and energy consumption related to obtaining polysilicon impact significantly on the total photovoltaic module cost and its energy payback time. Process simplifications can be performed, leading to cost reductions. Nowadays, among several approaches currently pursued to produce the so called Solar Grade Silicon, the chemical route, named Siemens process, is the dominant one. At the Instituto de Energía Solar research on this topic is focused on the chemical route, in particular on the polysilicon deposition step by chemical vapor deposition (CVD) from Trichlorosilane through a laboratory prototype. Valuable information about the phenomena involved in the polysilicon deposition process and the operating conditions is obtained from our experiments. A particular feature of our system is the inclusion of a mass spectrometer. The present work comprises spectra characterization of the polysilicon deposition chemical reaction, temperature and inlet gas mixture composition influence on the deposition rate and analysis of polysilicon deposition conditions for the ‘pop‐corn' phenomenon to appear, based on experimental experience (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Defect engineering during the contact co‐firing step in an industrial belt furnace
Authors: Peral Ana , Lelièvre Jean François , Recart Federico , del Cañizo Carlos 
Published: September 2012

AbstractThis work implements an optimization of the phosphorus gettering effect during the contact co‐firing step by means of both simulations and experiments in an industrial belt furnace. An optimized temperature profile, named ‘extended co‐firing step’, is presented. Simulations show that the effect of the short annealing on the final interstitial iron concentration depends strongly on the initial contamination level of the material and that the ‘extended co‐firing’ temperature profile can enhance the gettering effect within a small additional time. Experimental results using sister wafers from the same multicrystalline silicon ingot confirm these trends and show the potential of this new defect engineering tool to improve the solar cell efficiency (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Colorimetric Detection of Mercury Ions Based on Plasmonic Nanoparticles
Authors: Du Jianjun , Jiang Lin , Shao Qi , Liu Xiaogang , Marks Robert S. , Ma Jan , Chen Xiaodong 
Published: September 2012

AbstractThe development of rapid, specific, cost‐effective, and robust tools in monitoring Hg2+ levels in both environmental and biological samples is of utmost importance due to the severe mercury toxicity to humans. A number of techniques exist, but the colorimetric assay, which is reviewed herein, is shown to be a possible tool in monitoring the level of mercury. These assays allow transforming target sensing events into color changes, which have applicable potential for in‐the‐field application through naked‐eye detection. Specifically, plasmonic nanoparticle‐based colorimetric assay exhibits a much better propensity for identifying various targets in terms of sensitivity, solubility, and stability compared to commonly used organic chromophores. In this review, recent progress in the development of gold nanoparticle‐based colorimetric assays for Hg2+ is summarized, with a particular emphasis on examples of functionalized gold nanoparticle systems with oligonucleotides, oligopeptides, and functional molecules. Besides highlighting the current design principle for plasmonic nanoparticle‐based colorimetric probes, the discussions on challenges and the prospect of next‐generation probes for in‐the‐field applications are also presented.
Multi‐Reservoir Bioadhesive Microdevices for Independent Rate‐Controlled Delivery of Multiple Drugs
Authors: Chirra Hariharasudhan D. , Desai Tejal A. 
Published: September 2012

AbstractA variety of oral administrative systems such as enterically coated tablets, capsules, particles, and liposomes have been developed to improve oral bioavailability of drugs. However, they suffer from poor intestinal localization and therapeutic efficacy due to the various physiological conditions and high shear fluid flow. Fabrication of novel microdevices combined with the introduction of controlled release, improved adhesion, selective targeting, and tissue permeation may overcome these issues and potentially diminish the toxicity and high frequency of conventional oral administration. Herein, thin, asymmetric, poly(methyl methacrylate) (PMMA) microdevices are fabricated with multiple reservoirs using photolithography and reactive ion etching. They are loaded with different individual model drug in each reservoir. Enhanced bioadhesion of the microdevices is observed in the presence of a conjugated of targeting protein (tomato lectin) to the PMMA surface. As compared to drug encompassing hydrogels, an increase in drug permeation across the caco‐2 monolayer is noticed in the presence of a microdevice loaded with the same drug–hydrogel system. Also, the release of multiple drugs from their respective reservoirs is found to be independent from each other. The use of different hydrogel systems in each reservoir shows differences in the controlled release of the respective drugs over the same release period. These results suggest that, in the future, microfabricated unidirectional multi‐drug releasing devices will have an impact on the oral administration of a broad range of therapeutics.
Multiple Facets of the DNA Damage Response Contribute to the Radioresistance of Mouse Mesenchymal Stromal Cell Lines
Authors: Sugrue Tara , Brown James A.L. , Lowndes Noel F. , Ceredig Rhodri 
Published: September 2012

AbstractThe regeneration of the hematopoietic system following total body irradiation is supported by host-derived mesenchymal stromal cells (MSCs) within the bone marrow. The mechanisms used by MSCs to survive radiation doses that are lethal to the hematopoietic system are poorly understood. The DNA damage response (DDR) represents a cohort of signaling pathways that enable cells to execute biological responses to genotoxic stress. Here, we examine the role of the DDR in mediating the resistance of MSCs to ionizing radiation (IR) treatment using two authentic clonal mouse MSC lines, MS5 and ST2, and primary bulk mouse MSCs. We show that multiple DDR mechanisms contribute to the radio-resistance of MSCs: robust DDR activation via rapid γ-H2AX formation, activation of effective S and G2/M DNA damage checkpoints, and efficient repair of IR-induced DNA double-strand breaks. We show that MSCs are intrinsically programmed to maximize survival following IR treatment by expressing high levels of key DDR proteins including ATM, Chk2, and DNA Ligase IV; high levels of the anti-apoptotic, Bcl-2 and Bcl-XL; and low levels of the pro-apoptotic, Bim and Puma. As a result, we demonstrate that irradiated mouse MSCs withstand IR-induced genotoxic stress, continue to proliferate, and retain their capacity to differentiate long-term along mesenchymal-derived lineages. We have shown, for the first time, that the DDR plays key roles in mediating the radioresistance of mouse MSCs which may have important implications for the study and application of MSCs in allogeneic bone marrow transplantation, graft-versus-host disease, and cancer treatment.
A novel isoflurane anesthesia induction system for raccoons
Authors: Bentler Kevin T. , Gossett Daniel N. , Root J. Jeffrey 
Published: September 2012

AbstractWe developed a novel small‐volume (24‐L) conical‐shaped isoflurane anesthesia induction chamber for use in a den chamber and tested it along with 3 conventional stand‐alone induction chambers (2 clear acrylic plastic chambers and a cylindrical‐shaped chamber) to determine utility for daily short‐duration manipulations of captive raccoons (Procyon lotor). Although the conventional chambers were valuable, the majority of inductions were performed using the cone chamber in a pen setting. With the novel device, we were able to minimize the need for pre‐anesthetic handling of animals and eliminate the need for injectable anesthesia agents. As a result, side effects normally associated with injectable agents were avoided. Mean anesthesia induction time using the cone chamber was 3.4 min (SD = 0.90). When used as designed, conventional chambers worked well, with induction times ranging from 2.7 min to 5.4 min. Because the stand‐alone chambers were not reliant upon den chambers for use, they may provide greater utility for field work. The conical‐shaped induction chamber, however, provides an option for safe short‐duration anesthetization of captive raccoons and could perhaps be used with other species and in other research settings. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
Solvothermal Synthesis of One‐dimensional Chalcogenides Containing Group 13 Elements
Authors: Ewing Sarah J. , Romero M. Lucia , Hutchinson Jack , Powell Anthony V. , Vaqueiro Paz 
Published: September 2012

AbstractThe solvothermal synthesis and characterisation of [C6H16N2][GaS2]2 (1), [C6H16N2][Ga2Se3(Se2)] (2), and mixed‐metal phases with composition [C6H16N2][Ga2–xInxSe3(Se2)] (0 < x < 2)(3–5), is described. These materials have been characterised by single‐crystal and powder X‐ray diffraction, thermogravimetric analysis and UV/Vis diffuse reflectance spectroscopy. The materials contain one‐dimensional anionic chains. In 1, these chains consist of edge‐linked GaS4 tetrahedra, whilst in 2–5, the chains contain perselenide (Se2)2– units and comprise alternating four‐membered [M2Se2] and five‐membered [M2Se3] rings (where M = Ga, In). Compounds 3–5 represent the first examples of ternary mixed‐metal [M2Se3(Se2)]2– chains.
Preparation, Crystal Structure, and Thermal Decomposition of the Energetic Compound [Co(IMI)4(PA)](PA) (IMI = Imidazole and PA = Picrate)
Authors: Wu Bi‐Dong , Zhang Tong‐Lai , Yang Li , Zhang Jian‐Guo , Zhou Zun‐Ning 
Published: September 2012

AbstractThe novel multi‐ligand coordination compound [Co(IMI)4(PA)](PA) (1) was synthesized by using imidazole (IMI) and picrate (PA) and characterized by elemental analysis and FT‐IR spectroscopy. The crystal structure was determined by X‐ray single crystal diffraction and the crystallographic data showed that the compound crystallizes in the triclinic space group P$\bar{1}$ (α = 8.839(2) Å, b = 13.550(3) Å, c = 13.840(3) Å, α = 68.386(6)°, β = 88.349(9)°, and γ = 87.494(9)°). Furthermore, the CoII ion is six‐coordinated by four nitrogen atoms from four imidazole ligands and two oxygen atoms from a PA group. Its thermal decomposition mechanism was determined based on differential scanning calorimetry (DSC) and thermogravimetry‐derivative thermogravimetry (TG‐DTG) analysis. The kinetic parameters of the first exothermic process were studied by using Kissinger's and Ozawa's method, respectively. The energy of combustion and the enthalpy of formation were measured and calculated. They showed good combustion performance of the compound. Additionally, the sensitivity properties were determined with standard methods. The results of all these studies showed that [Co(IMI)4(PA)](PA) has potential application as ignition composition.
Flat vs. Folded Chelate Rings in cis‐PtIIa2 (a = NH3, a2 = en, a2 = 2, 2′‐bpy) Complexes of Twofold Substituted Diazine Ligands
Authors: von Grebe Philipp , Sanz Miguel Pablo J. , Lippert Bernhard 
Published: September 2012

AbstractAcid‐base and ligating properties of three bis(substituted)pyrazine (pz) and pyrimidine (pym) ligands (pyrazine‐2, 5‐dicarboxylic acid, 2, 5‐pzdcH2, 2, 3‐bis(pyridine‐2‐yl)pyrazine, 2, 3‐bppz, pyrimidine‐4, 6‐dicarboxylic acid, 4, 6‐pmdcH2) toward cis‐PtIIa2 (a = NH3, a2 = en, a2 = 2, 2′‐bpy) have been studied. Combinations of pz‐N/pym‐N with donor atoms of the substituents lead to 5‐membered platinum chelates, but exclusive N, N‐coordination through the pyridyl substituents of 2, 3‐bppz can lead to a 7‐membered platinum chelate with a characteristic L‐shape of the resulting cation. It is observed for PtII(2, 2′‐bpy), yet not for PtII(en), and is a consequence of differences in sterical interactions between the 2, 3‐bppz ligand and the coligands of PtII.
Self‐expandable Metallic Stents in Patients with Stage IV Obstructing Colorectal Cancer
Authors: Lamazza Antonietta , Fiori Enrico , Schillaci Alberto , DeMasi Ercole , Pontone Stefano , Sterpetti Antonio V. 
Published: September 2012

AbstractBackgroundThe aim of the present study was to analyze the results of our experience with elective placement of self‐expandable metallic stents (SEMS) in patients with stage IV obstructing colorectal cancer. A systematic review of the literature was also carried out to analyze the factors influencing the results of SEMS placement and to determine if there has been any improvement in the more recent period.Materials and methodsThe results of a personal series of 100 patients were analyzed. There was no case of mortality or major morbidity. The systematic review included 27 articles published from April 2007 to December 2011.ResultsIn our experience the technical success rate was 96 % and the clinical success rate was 92 %. During the follow‐up period a repeat colonoscopy was needed in 31 % of the patients for recurrent symptoms of obstruction due to fecal impaction (19 %), tumor growth (8 %), or stent dislodgment (4 %). Review of the literature showed similar results, with a significant improvement in the reports of the last 6 years; procedures performed on an emergency basis had poorer results.ConclusionsSelf‐expandable metallic stent placement offers a valid alternative to surgery in patients with obstructing stage IV colorectal cancer, but careful follow‐up is required.
Transcriptional Regulation of Desaturase Genes in Pichia pastoris GS115
Authors: Yu Ai‐Qun , Shi Tong‐Lei , Zhang Biao , Xing Lai‐Jun , Li Ming‐Chun 
Published: September 2012

AbstractHere we investigated the regulation of Pichia pastoris desaturase genes by low temperature and exogenous fatty acids in the late‐exponential phase at the transcriptional level. Time‐course studies of gene expression showed that mRNA levels of four desaturase genes were rapidly and transiently enhanced by low temperature and suppressed by exogenous oleic acid. Stearic acid showed no obvious repression of mRNA levels of Fad12 and Fad15 and a slight increase in Fad9A and Fad9B mRNA levels. Using a promoter–reporter gene construct, we demonstrated that the pFAD15 promoter activity was induced by low temperature in a time‐dependent manner and reduced in a dose‐ and time‐dependent manner by unsaturated fatty acids. Also, there was no absolute correlation between mRNA abundance and production of corresponding fatty acids. Disruption of Spt23 resulted in a decrease in transcript levels of Fad9A and Fad9B, but had little effect on the other desaturase genes. Consistent with these observations, a decrease in the relative amount of oleic acid (OLA) and an increase in the relative content of linoleic acid and ALA with different degrees were clearly observed in the stationary phase cells of ΔSpt23 mutant. Further analysis showed that the effect of low‐temperature activation and OLA inhibition on expression of Fad9A and Fad9B seemed to disappear after disruption of the Spt23 gene, which indicated that Spt23p is essential for the expression of two Δ9‐desaturase genes internally and probably involved in the regulation of Δ9‐desaturase genes transcription in response to external stimuli, and thereby plays a role in the synthesis of OLA.