bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pickleball Participation and the Health and Well-Being of Adults—A Scoping Review
Authors: Stroesser Kim , Mulcaster Adam , Andrews David M. 
Published: July 2024

Background: Pickleball has grown tremendously in recent years, yet little evidence exists regarding pickleball-related injuries. This scoping review extends current work on pickleball participation by identifying positive and negative health effects associated with the sport. We summarize how pickleball impacts the health and well-being of adult participants. Methods: Searches were conducted on MEDLINE, CINAHL, ProQuest Nursing, ERIC, SPORTDiscus, PsycINFO, Scopus, CBCA Complete, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and ProQuest Dissertations and Theses. Selected studies considered aspects of health and/or well-being of adult pickleball participants. Using the population/concept/context framework, participants were healthy, able-bodied adults 18 years of age or over, who had played pickleball at least once. The positive and negative outcomes of pickleball on participants’ health and well-being (concept) within the context of pickleball participation were examined. Full-text articles written in English since 2013 were included. Extracted data were tabulated, and a descriptive summary with thematic analysis was completed. Results: This scoping review comprised 27 articles that met the inclusion criteria. Pickleball is promising as an exercise intervention for all adults, and there is evidence of positive social and psychological effects, and health and fitness benefits to participating in pickleball by older adults. Conclusions: Although we are still in the early stages of studying pickleball, there have been some documented health benefits of using the sport as a physical exercise intervention for adults. More research is needed on the types, prevalence, and severity of pickleball injuries and the sport’s impact on younger players.
Isokinetic Peak Torque Improvement and Shoulder Muscle Ratios Imbalance Correction After Specific Strength Training on a New Ballistic Throwing Device: A Randomized Controlled Trial
Authors: Agrebi Brahim , Dhahbi Wissem , Abidi Hatem , Kasmi Sofien , Houas Narjes , Chtara Mokhtar , Chamari Karim 
Published: July 2024

Context: The aim of this study was to investigate the effects of 8-week ballistic-strength-training program using a validated specific throwing device (ie, Arm/Shoulder Specific Strength Device), on isokinetic shoulders’ rotation muscle-torques and ratios as well as range of motion in team handball players. Design: A repeated-measures experimental design with a randomized controlled trial was used. Methods: Twenty-six high-level competitive male U-19 team handball players were randomly assigned into training (TG, n = 15) and control (n = 11) groups. The TG undertook a twice a week for 8-week periodized throws program with an individually predetermined optimal load. The program incorporated shackled eccentric and concentric exercises using the Arm/Shoulder Specific Strength Device. Peak torques, functional, and conventional ratios for both arms at different angular velocities (60°·s−1, 180°·s−1, and 300°·s−1) were assessed over time and between groups, using an isokinetic dynamometer. Results: A significant improvement for TG (P < .01; d = 1.13 [moderate]; +20.2%) of the concentric peak torques for dominant arm in external rotation was observed at 300°·s−1. Significant (P < .05–.01) increases were also noted for nondominant arm at the 3 studied angular velocities. In addition, 300°·s−1 eccentric peak torques of the dominant arm and nondominant arm have significantly improved for both external and internal rotations (P < .05; d = .99 [moderate] and d = 1.21 [large]; +15.7% and + 17.9%, respectively) with small changes at the other angular assessed velocities. Posttraining, TG’s dominant arm showed significant improvements (P < .05–.01) in functional and conventional ratios at all velocities. Notably, significant differences (P < .05–.01) were observed at 60°·s−1 and across all velocities when comparing the TG with the control group. TG showed significant increase for internal rotation and external rotation shoulder range of motions (P < .05; d = 1.22–1.27 [large]), +5.0% and +7.7%, respectively). Conclusions: The specific 8-week throwing training program on the Arm/Shoulder Specific Strength Device showed significant performance improvements in almost all assessed isokinetic concentric and eccentric peak torques as well as internal and external range of motion increase for both arms while ensuring rotator cuff torque ratios and shoulder mobility in team handball real sport-specific condition.
Metatranscriptomic response of deep ocean microbial populations to infusions of oil and/or synthetic chemical dispersant
Authors: Peña-Montenegro Tito D. , Kleindienst Sara , Allen Andrew E. , Eren A. Murat , McCrow John P. , Arnold Jonathan , Joye Samantha B. 
Published: July 2024

ABSTRACT

Oil spills are a frequent perturbation to the marine environment that has rapid and significant impacts on the local microbiome. Previous studies have shown that exposure to synthetic dispersant alone did not enhance heterotrophic microbial activity or oxidation rates of specific hydrocarbon components but increased the abundance of some taxa (e.g.,
Colwellia
). In contrast, exposure to oil, but not dispersants, increased the abundance of other taxa (e.g.,
Marinobacter
) and stimulated hydrocarbon oxidation rates. Here, we advance these findings by interpreting metatranscriptomic data from this experiment to explore how and why specific components of the microbial community responded to distinct organic carbon exposure regimes. Dispersant alone was selected for a unique community and for dominant organisms that reflected treatment- and time-dependent responses. Dispersant amendment also led to diverging functional profiles among the different treatments. Similarly, oil alone was selected for a community that was distinct from treatments amended with dispersants. The presence of oil and dispersants with added nutrients led to substantial differences in microbial responses, likely suggesting increased fitness driven by the presence of additional inorganic nutrients. The oil-only additions led to a marked increase in the expression of phages, prophages, transposable elements, and plasmids (PPTEPs), suggesting that aspects of microbial community response to oil are driven by the “mobilome,” potentially through viral-associated regulation of metabolic pathways in ciliates and flagellates that would otherwise throttle the microbial community through grazing.

IMPORTANCE
Microcosm experiments simulated the April 2010 Deepwater Horizon oil spill by applying oil and synthetic dispersants (Corexit EC9500A and EC9527A) to deep ocean water samples. The exposure regime revealed severe negative alterations in the treatments’ heterotrophic microbial activity and hydrocarbon oxidation rates. We expanded these findings by exploring metatranscriptomic signatures of the microbial communities during the chemical amendments in the microcosm experiments. Here we report how dominant organisms were uniquely associated with treatment- and time-dependent trajectories during the exposure regimes; nutrient availability was a significant factor in driving changes in metatranscriptomic responses. Remarkable signals associated with PPTEPs showed the potential role of mobilome and viral-associated survival responses. These insights underscore the time-dependent environmental perturbations of fragile marine environments under oil and anthropogenic stress.
Maximum likelihood estimators for colony-forming units
Authors: Martini K. Michael , Boddu Satya Spandana , Nemenman Ilya , Vega Nic M. 
Published: July 2024

ABSTRACT

Measuring the abundance of microbes in a sample is a common procedure with a long history, but best practices are not well-conserved across microbiological ﬁelds. Serial dilution methods are commonly used to dilute bacterial cultures to produce countable numbers of colonies, and from these counts, to infer bacterial concentrations measured in colony-forming units (CFUs). The most common methods to generate data for CFU point estimates involve plating bacteria on (or in) a solid growth medium and counting their resulting colonies or counting the number of tubes at a given dilution that have growth. Traditionally, these types of data have been analyzed separately using different analytic methods. Here, we build a direct correspondence between these approaches, which allows one to extend the use of the most probable number method from the liquid tubes experiments, for which it was developed, to the growth plates by viewing colony-sized patches of a plate as equivalent to individual tubes. We also discuss how to combine measurements taken at different dilutions, and we review several ways of analyzing colony counts, including the Poisson and truncated Poisson methods. We test all point estimate methods computationally using simulated data. For all methods, we discuss their relevant error bounds, assumptions, strengths, and weaknesses. We provide an online calculator for these estimators.
Estimation of the number of microbes in a sample is an important problem with a long history. Yet common practices, such as combining results from different measurements, remain sub-optimal. We provide a comparison of methods for estimating abundance of microbes and detail a mapping between different methods, which allows to extend their range of applicability. This mapping enables higher precision estimates of colony-forming units (CFUs) using the same data already collected for traditional CFU estimation methods. Furthermore, we provide recommendations for how to combine measurements of colony counts taken across dilutions, correcting several misconceptions in the literature.
Childhood neurodivergent traits, inflammation and chronic disabling fatigue in adolescence: a longitudinal case–control study
Authors: Quadt Lisa , Csecs Jenny , Bond Rod , Harrison Neil A , Critchley Hugo D , Davies Kevin A , Eccles Jessica 
Published: July 2024

ObjectivesTo test whether inflammatory processes link the expression of childhood neurodivergent traits to chronic disabling fatigue in adolescence.DesignLongitudinal case–control study.SettingWe analysed data from The Avon Longitudinal Study of Parents and Children (ALSPAC).Participants8115 and 8036 children of the ALSPAC cohort at ages 7 and 9 years, respectively, 4563 of whom also completed self-report measures at age 18 years.Primary and secondary outcome measuresWe assessed if children scoring above screening threshold for autism/attention deficit hyperactivity disorder (ADHD) at ages 7 and 9 years had increased risk of chronic disabling fatigue at age 18 years, computing ORs and CIs for effects using binary logistic regression. Mediation analyses were conducted to test if an inflammatory marker (interleukin 6 (IL-6)) at age 9 years linked neurodivergent traits to chronic disabling fatigue at age 18 years.ResultsChildren with neurodivergent traits at ages 7 and 9 years were two times as likely to experience chronic disabling fatigue at age 18 years (likely ADHD OR=2.18 (95% CI=1.33 to 3.56); p=0.002; likely autism OR=1.78 (95% CI=1.17 to 2.72); p=0.004). Levels of IL-6 at age 9 were associated with chronic disabling fatigue at age 18 (OR=1.54 (95% CI=1.13 to 2.11); p=0.006). Inflammation at age 9 years mediated effects of neurodivergent traits on chronic disabling fatigue (indirect effect via IL-6: ADHD b=1.08 (95% CI=1.01 to 1.15); autism b=1.06; (95% CI=1.03 to 1.10)). All effects remained significant when controlling for the presence of depressive symptoms.ConclusionsOur results indicate higher risk of chronic disabling fatigue for children with neurodivergent traits, likely linked to higher levels of inflammation. The implementation of transdiagnostic screening criteria to inform support strategies to counteract risk early in life is recommended.
Supportive care interventions in metastatic bone disease: scoping review
Authors: Simister Samuel K , Bhale Rahul , Cizik Amy M , Wise Barton L , Thorpe Steven W , Ferrell Betty , Randall R Lor , Fauer Alex 
Published: July 2024

BackgroundPatients with secondary metastatic involvement of the musculoskeletal system due to primary cancers are a rapidly growing population with significant risks for health-related end-of-life morbidities. In particular, bone metastases or metastatic bone disease (MBD) imparts significant adversity to remaining quality of life. No rigorous review of clinical trials on the use of supportive care interventions for MBD has been conducted. The objective of this review was to examine the characteristics of supportive care interventions for MBD and critically appraise study designs, key findings, and quality of evidence of the research.MethodsWe searched for published clinical trials, systematic reviews and meta-analyses in PubMED, CINAHL and Google Scholar for articles published between September 2017 and September 2022. Some examples of Medical Subject Headings terms were: ‘secondary neoplasm’, ‘metastatic bone disease’, ‘palliative care’ and ‘supportive care intervention’. Quality of published evidence was evaluated based on treatment types and study design.ResultsAfter reviewing 572 publications, 13 articles were included in the final review and evaluation including seven clinical trials, two trial protocols and four systematic reviews. Feasible interventions included enhanced palliative care consultation, palliative radiotherapy and alternative medicines. Interventions addressed primary endpoints of fatigue (N=4, 31%), pain (N=3, 23%) or cancer-related symptoms (N=3, 23%) with patient-reported outcome instruments. No interventions reported on fracture complications or endpoints, specifically. The quality of most studies was moderate to strong.ConclusionSupportive care interventions for MBD are feasible and the impact is measurable via patient-reported outcome measures. While the evidence for interventions was moderate to strong, there are very few specific controlled trials for skeletal-related events and impacts of social determinants of health. Further clinical trials are needed to define supportive care interventions for MBD that demonstrate reduced risk of fracture and that mitigate the reduced quality of life when negative musculoskeletal outcomes arise.
The environmental low-frequency background for macro-calorimeters at the millikelvin scale
Authors: Aragão L. , Armigliato A. , Brancaccio R. , Brofferio C. , Castellaro S. , D’Addabbo A. , De Luca G. , Del Corso F. , Di Sabatino S. , Liu R. , Marini L. , Nutini I. , Quitadamo S. , Ruggieri P. , Vetter K. J. , Zavatarelli M. , Zucchelli S. 
Published: July 2024

AbstractMany of the most sensitive physics experiments searching for rare events, like neutrinoless double beta ($$0\nu \beta \beta $$

0
ν
β
β

) decay, coherent elastic neutrino nucleus scattering and dark matter interactions, rely on cryogenic macro-calorimeters operating at the mK-scale. Located underground at the Gran Sasso National Laboratory (LNGS), in central Italy, CUORE (Cryogenic Underground Observatory for Rare Events) is one of the leading experiments for the search of $$0\nu \beta \beta $$

0
ν
β
β

decay, implementing the low-temperature calorimetric technology. We present a novel multi-device analysis to correlate environmental phenomena with the low-frequency noise of low-temperature calorimeters. Indeed, the correlation of marine and seismic data with data from a couple of CUORE detectors indicates that cryogenic detectors are sensitive not only to intense vibrations generated by earthquakes, but also to the much fainter vibrations induced by marine microseisms in the Mediterranean Sea due to the motion of sea waves. Proving that cryogenic macro-calorimeters are sensitive to such environmental sources of noise opens the possibility of studying their impact on the detectors physics-case sensitivity. Moreover, this study could pave the road for technology developments dedicated to the mitigation of the noise induced by marine microseisms, from which the entire community of cryogenic calorimeters can benefit.
Role of hidden-color components in the tetraquark mixing model
Authors: Kim Hungchong , Kim K. S. 
Published: July 2024

AbstractMultiquarks can have two-hadron components and hidden-color components in their wave functions. The presence of two-hadron components in multiquarks introduces a potential source of confusion, particularly with respect to their resemblance to hadronic molecules. On the other hand, hidden-color components are essential for distinguishing between multiquarks and hadronic molecules. In this work, we study the hidden-color components in the wave functions of the tetraquark mixing model, a model that has been proposed as a suitable framework for describing the properties of two nonets in the$$J^{P}=0^{+}$$JP=0+channel: the light nonet [$$a_{0} (980)$$a0(980),$$K_{0}^{*} (700)$$K0∗(700),$$f_{0} (500)$$f0(500),$$f_{0} (980)$$f0(980)] and the heavy nonet [$$a_{0} (1450)$$a0(1450),$$K_{0}^* (1430)$$K0∗(1430),$$f_{0} (1370)$$f0(1370),$$f_{0} (1500)$$f0(1500)]. Our analysis reveals a substantial presence of hidden-color components within the tetraquark wave functions. To elucidate the impact of hidden-color components on physical quantities, we conduct computations of the hyperfine masses,$$\langle V_{CS}\rangle $$⟨VCS⟩, for the two nonets, considering scenarios involving only the two-meson components and those incorporating the hidden-color components. We demonstrate that the hidden-color components constitute an important part of the hyperfine masses, such that the mass difference formula,$$\Delta M\approx \Delta \langle V_{CS}\rangle $$ΔM≈Δ⟨VCS⟩, which has been successful for the two nonets, cannot be achieved without the hidden-color contributions. This can provide another evidence supporting the tetraquark nature of the two nonets.
Stability investigations of de Sitter inflationary solutions in power-law extensions of the Starobinsky model
Authors: Pham Tuyen M. , Nguyen Duy H. , Do Tuan Q. , Kao W. F. 
Published: July 2024

AbstractIn this paper, we would like to examine whether stable de Sitter inflationary solutions appear within power-law extensions of the Starobinsky model. In particular, we will address general constraints for the existence along with the stability of de Sitter inflationary solutions in a general case involving not only the Starobinsky $$R^2$$

R
2

term but also an additional power-law $$R^n$$

R
n

one. According to the obtained results, we will be able to identify which extension is more suitable for an early inflationary phase rather than a late-time cosmic acceleration phase. To be more specific, we will consider several values of n to see whether the corresponding de Sitter inflationary solutions are stable or not.
Probing black holes in a dark matter spike of M87 using quasinormal modes
Authors: Liu Dong , Yang Yi , Long Zheng-Wen 
Published: July 2024

AbstractDark matter density can be significantly enhanced by the supermassive black hole at the galactic center, leading to a structure called dark matter spike. Dark matter spike may change the spacetime properties of black holes that constitute deviations from GR black holes. Based on these interesting background, we construct a set of solutions of black holes in a dark matter spike under the Newtonian approximation and full relativity. Combining the mass model of M87, we study the quasinormal modes of black holes in the scalar field and axial gravitational perturbation, then compared them with Schwarzschild black hole. Besides, the impacts of dark matter on the quasinormal mode of black holes have been studied in depth. In particular, in the axial gravitational perturbation, our results show that the impacts of dark matter spike on the quasinormal mode of black holes can reach up to $$10^{-4}$$

10

-
4

. These new features from quasinormal mode of black holes under the Newtonian approximation and full relativity may provide some help for the establishment of the final dark matter model, and provide a new thought for the indirect detection of dark matter.
Photon emissions from Kerr equatorial geodesic orbits
Authors: Su Yanming , Guo Minyong , Yan Haopeng , Chen Bin 
Published: July 2024

AbstractWe consider the light emitters moving freely along the geodesics on the equatorial plane near a Kerr black hole and study the observability of these emitters. To do so, we assume these emitters emit photons isotropically and monochromatically, and we compute the photon escaping probability (PEP) and the maximum observable blueshift (MOB) of the photons that reach infinity. We obtain numerical results of PEP and MOB for the emitters along various geodesic orbits, which exhibit distinct features for the trajectories of different classes. In particular, we find that the plunging emitters could have considerable observability even in the near-horizon region. This interesting observational feature becomes more significant for the high-energy emitters near a high-spin black hole. As the radiatively-inefficient accretion flow may consist of plunging emitters, the present work could be of great relevance to the astrophysical observations.
Mutant IDH Modulates Suppressive Myeloid Populations in Malignant Glioma
Authors: Grewal Eric P. , Richardson Leland G.K. , Sun Jing , Ramapriyan Rishab , Martinez-Lage Maria , Miller Julie J. , Carter Bob S. , Cahill Daniel P. , Curry William T. , Choi Bryan D. 
Published: July 2024

Abstract

Purpose:
Mutations in the isocitrate dehydrogenase (IDH) genes IDH1 and IDH2 have critical diagnostic and prognostic significance in diffuse gliomas. Neomorphic mutant IDH activity has been previously implicated in T-cell suppression; however, the effects of IDH mutations on intratumoral myeloid populations remain underexplored. In this study, we investigate the influence of IDH status on the myeloid compartment using human glioma specimens and preclinical models.

Experimental Design:
We performed RNA sequencing and quantitative immunofluorescence on newly diagnosed, treatment-naive IDH-mutant grade 4 astrocytoma and IDH-wild-type (IDH-WT) glioblastoma (GBM) specimens. We also generated a syngeneic murine model, comparing transcriptomic and cell-level changes in paired isogenic glioma lines that differ only in IDH mutational status.

Results:
Among patient samples, IDH-mutant tumors displayed an underrepresentation of suppressive myeloid transcriptional signatures, which was confirmed at the cellular level with decreased numbers of intratumoral M2-like macrophages and myeloid-derived suppressor cells. Introduction of the mutant IDH enzyme into murine glioma was sufficient to recapitulate the transcriptomic and cellular shifts observed in patient samples.

Conclusions:
We provide transcriptomic and cellular evidence that mutant IDH is associated with a quantitative reduction of suppressive myeloid cells in gliomas and that introduction of the mutant enzyme is sufficient to result in corresponding cellular changes using an in vivo preclinical model. These data advance our understanding of high-grade gliomas by identifying key myeloid cell populations that are reprogrammed by mutant IDH and may be targetable through therapeutic approaches.