bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research on Mass Transfer Columns: passé?
Authors: Schultes M. 
Published: August 2013

AbstractSince university research on mass transfer columns has decreased significantly in recent years, it is discussed whether the current knowledge of mass transfer technology for trays, packing materials, and column internals is sufficient to design energy‐ and cost‐efficient systems. Points of view are described that have not yet been clarified from an industrial position and should play an important role in future research. In addition to the thermodynamics of industrially relevant systems, an improved description of the fluid dynamics and mass transfer efficiency in trayed and packed columns is included. Research should focus beyond ideal test mixtures which employ standardized test equipments and test systems. Industrial parameters such as foams and solids as well as chemical and catalytic mass transfer are also of great interest.
A Designed 5‐Fluorouracil‐Based Bridged Silsesquioxane as an Autonomous Acid‐Triggered Drug‐Delivery System
Authors: Giret Simon , Théron Christophe , Gallud Audrey , Maynadier Marie , Gary‐Bobo Magali , Garcia Marcel , Wong Chi Man Michel , Carcel Carole 
Published: August 2013

AbstractTwo new prodrugs, bearing two and three 5‐fluorouracil (5‐FU) units, respectively, have been synthesized and were shown to efficiently treat human breast cancer cells. In addition to 5‐FU, they were intended to form complexes through H‐bonds to an organo‐bridged silane prior to hydrolysis‐condensation through sol–gel processes to construct acid‐responsive bridged silsesquioxanes (BS). Whereas 5‐FU itself and the prodrug bearing two 5‐FU units completely leached out from the corresponding materials, the prodrug bearing three 5‐FU units was successfully maintained in the resulting BS. Solid‐state NMR (29Si and 13C) spectroscopy show that the organic fragments of the organo‐bridged silane are retained in the hybrid through covalent bonding and the 1H NMR spectroscopic analysis provides evidence for the hydrogen‐bonding interactions between the prodrug bearing three 5‐FU units and the triazine‐based hybrid matrix. The complex in the BS is not affected under neutral medium and operates under acidic conditions even under pH as high as 5 to deliver the drug as demonstrated by HPLC analysis and confirmed by FTIR and 13C NMR spectroscopic studies. Such functional BS are promising materials as carriers to avoid the side effects of the anticancer drug 5‐FU thanks to a controlled and targeted drug delivery.
ChemInform Abstract: Synthesis and Crystal Structures of the Alkali Aluminum Thiohypodiphosphates MIAIP2S6 (M: Li, Na).
Authors: Kuhn Alexander , Eger Roland , Nuss Juergen , Lotsch Bettina V. 
Published: August 2013

AbstractLiAlP2S6 (I) and NaAlP2S6 (II) are prepared by solid state reaction of stoichiometric amounts of Na or Li2S, Al, P, and S (evacuated quartz ampules, 10023 K, 1 d).
ChemInform Abstract: Dihydronium Tetrachromate (Vl), (H3O)2Cr4O13.
Authors: Kulikov Vladislav , Meyer Gerd 
Published: August 2013

AbstractSingle crystals of (H3O)2Cr4O13 are obtained from an aqueous mother liquor containing Na2Cr2O7, CrO3, AgClO4, and theobromine in HNO3 after 6 months.
ChemInform Abstract: Solution‐Phase Synthesis of Highly Conductive Tungsten Diselenide Nanosheets.
Authors: Antunez Priscilla D. , Webber David H. , Brutchey Richard L. 
Published: August 2013

AbstractWSe2 nanosheets are prepared by injecting tBu2Se2 into a solution of WCl4 in dodecylamine at 150 °C (N2 atmosphere, heating to 225 °C, 6 h, quenching).
ChemInform Abstract: Room Temperature Magnetic Rare‐Earth Iron Garnet Thin Films with Ordered Mesoporous Structure.
Authors: Suchomski Christian , Reitz Christian , Sousa Celia T. , Araujo Joao P. , Brezesinski Torsten 
Published: August 2013

AbstractHighly crystalline thin films of lanthanoid Fe garnet (Ln3Fe5O12, Ln: Y, Gd, Tb, Dy) with cubic networks of interconnected pores (average 17 nm in diameter) are prepared through facile polymer (poly‐ω‐hydroxypoly(ethylene‐co‐butylene)‐co‐poly(ethylene oxide)) templating of hydrated nitrate salts in methoxyethanol and EtOH.
ChemInform Abstract: Observation of the Sixth Polymorph of BiB3O6: In situ High‐Pressure Raman Spectroscopy and Synchrotron X‐Ray Diffraction Studies on the β‐Polymorph.
Authors: Cong Rihong , Yang Tao , Sun Junliang , Wang Yingxia , Lin Jianhua 
Published: August 2013

AbstractA pressure‐induced phase transition from β‐BiB3O6 to a new polymorph, ζ‐BiB3O6 between 11.5 and 18.5 GPa is identified by the combination of in situ Raman spectroscopy and synchrotron XRD.
ChemInform Abstract: Synthesis, Structure, and Spectroscopy of Two Ternary Uranium(IV) Thiophosphates: UP2S9 and UP2S7 Containing P2S92‐ and P2S72‐ Ligands.
Authors: Babo Jean‐Marie , Jouffret Laurent , Lin Jian , Villa Eric M. , Albrecht‐Schmitt Thomas E. 
Published: August 2013

AbstractUP2S9 (I) and UP2S7 (II) are prepared by solid state reaction of 1:1:2:1 mixtures of BaS, U, P2S5, and S or Li2S, U, P2S5, and S, resp.
ChemInform Abstract: Synthesis and Lewis Acid Properties of (ReO3F)∞ and the X‐Ray Crystal Structures of (HF)2ReO3F·HF and [N(CH3)4]2 [{ReO3(μ‐F)}3(μ3‐O)] ·CH3CN.
Authors: Ivanova Maria V. , Koechner Tobias , Mercier Helene P. A. , Schrobilgen Gary J. 
Published: August 2013

Abstract(ReO3F)∞ (I) is prepared as a precursor by solvolysis of Re2O7 in anhydrous HF (aHF) followed by room temperature fluorination of the formed H2O.
ChemInform Abstract: Peptide Fragment Coupling Using a Continuous‐Flow Photochemical Rearrangement of Nitrones.
Authors: Zhang Yuan , Blackman Melissa L. , Leduc Andew B. , Jamison Timothy F. 
Published: August 2013

AbstractA general, versatile, efficient and novel approach for the synthesis of simple and complex peptide bonds via the title rearrangement is developed.
ChemInform Abstract: An Efficient and Diastereoselective Synthesis of Hydrazino Amides via a Novel One‐Pot Three‐Component Reaction.
Authors: Ramezanpour Sorour , Balalaie Saeed , Rominger Frank , Bijanzadeh Hamid Reza 
Published: August 2013

AbstractThe simple and mild title reaction affords the corresponding hydrazine pseudopeptide derivatives, which are isolated as single diastereomer, in good yields.
ChemInform Abstract: One‐Pot Procedure for the Introduction of Three Different Bonds onto Terminal Alkynes Through N‐Sulfonyl‐1,2,3‐triazole Intermediates.
Authors: Miura Tomoya , Tanaka Takamasa , Biyajima Tsuneaki , Yada Akira , Murakami Masahiro 
Published: August 2013

AbstractThis method yields α‐substituted α‐amino ketone derivatives which are substructures of bioactive compounds and intermediates in the synthesis of α‐amino alcohols.
ChemInform Abstract: Highly Chemo‐ and Enantioselective Cross‐Benzoin Reaction of Aliphatic Aldehydes and α‐Ketoesters.
Authors: Thai Karen , Langdon Steven M. , Bilodeau Francois , Gravel Michel 
Published: August 2013

AbstractDensely oxygenated syn‐diols are available by diastereoselective reduction of the primary products.
ChemInform Abstract: Palladium‐Catalyzed Direct Arylation of Methyl Sulfoxides with Aryl Halides.
Authors: Jia Tiezheng , Bellomo Ana , EL Baina Kawtar , Dreher Spencer D. , Walsh Patrick J. 
Published: August 2013

AbstractThe reaction of various organyl methyl sulfoxides with aryl bromides proceeds with high yields [viz.
ChemInform Abstract: NHC PdII Complex Bearing 1,6‐Hexylene Linker: Synthesis and Catalytic Activity in the Suzuki—Miyaura and Heck—Mizoroki Reactions.
Authors: Liu Qing‐Xiang , Zhang Wei , Zhao Xiao‐Jun , Zhao Zhi‐Xiang , Shi Meng‐Chao , Wang Xiu‐Guang 
Published: August 2013

AbstractThis new functionalized NHC‐catalyst shows efficient catalytic activity in the Suzuki‐Miyaura cross‐coupling reaction under aerobic conditions and in water as solvent, and can be also used for Heck coupling reactions.
ChemInform Abstract: Rh(I)‐Catalyzed Decarbonylation of Diynones via C—C Activation: Orthogonal Synthesis of Conjugated Diynes.
Authors: Dermenci Alpay , Whittaker Rachel E. , Dong Guangbin 
Published: August 2013

AbstractA wide range of symmetrical and unsymmetrical conjugated diynes are prepared.
ChemInform Abstract: Synthesis of Highly Substituted Tetrahydrofurans by Catalytic Polar‐Radical‐Crossover Cycloadditions of Alkenes and Alkenols.
Authors: Grandjean Jean‐Marc M. , Nicewicz David A. 
Published: August 2013

AbstractThe products are isolated as inseparable mixtures of diastereomers, some also containing traces of additional diastereomers not shown in the scheme.
ChemInform Abstract: KF/Al2O3/PEG‐400: An Efficient Catalytic System for the Fiesselmann‐Type Synthesis of Thiophene Derivatives.
Authors: Bezboruah Pranjal , Gogoi Pranjal , Gogoi Junali , Boruah Romesh C. 
Published: August 2013

AbstractA simple protocol is developed to synthesize novel non‐steroidal and steroidal thiophenes via reaction of β‐halo‐α,β‐unsaturated aldehydes with thioacetic acid ethyl ester.
ChemInform Abstract: Nickel(II)‐Catalyzed Enantioselective 1,3‐Dipolar Cycloaddition of Azomethine Imines with Alkylidene Malonates.
Authors: Li Jiangting , Lian Xiangjin , Liu Xiaohua , Lin Lili , Feng Xiaoming 
Published: August 2013

AbstractOptimized conditions render possible the preparation of various pyrazolidinone derivatives as important substructures.
ChemInform Abstract: Copper‐Mediated C—H/C—H Biaryl Coupling of Benzoic Acid Derivatives and 1,3‐Azoles.
Authors: Nishino Mayuko , Hirano Koji , Satoh Tetsuya , Miura Masahiro 
Published: August 2013

AbstractThe title coupling reaction based on a double N,N‐coordination strategy.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed [4 + 2] Cycloaddition of Nitroalkenes with Oxodienes.
Authors: Chen Xiang‐Yu , Sun Li‐Hui , Ye Song 
Published: August 2013

AbstractA plausible catalytic cycle for the unprecedented [4 + 2] cycloaddition of nitroalkenes and oxodienes is given.
ChemInform Abstract: One‐Pot Cycloisomerization/Hetero‐Diels—Alder Reaction of 1,6‐Enynes with Aldehydes Catalyzed by Rhodium and a Broensted Acid.
Authors: Ishida Mana , Tanaka Ken 
Published: August 2013

AbstractThis one‐pot protocol features mild conditions and high atom efficiency.
ChemInform Abstract: One‐Pot Catalysis of Dehydrogenation of Cyclohexanones to Phenols and Oxidative Heck Coupling: Expedient Synthesis of Coumarins.
Authors: Kim Donghee , Min Minsik , Hong Sungwoo 
Published: August 2013

AbstractA simple procedure is elaborated for the preparation of coumarins (III) by an oxidation of cyclohexanones (I) followed by an oxidative Heck coupling‐cyclization process of resulting phenols with butyl acrylate.
ChemInform Abstract: Ir(I)‐Catalyzed Synthesis of N‐Substituted Pyridones from 2‐Alkoxypyridines via C—O Bond Cleavage.
Authors: Pan Shiguang , Ryu Naoto , Shibata Takanori 
Published: August 2013

AbstractA cationic Ir(I) complex catalyzes O‐to‐N‐alkyl migration in pyridines bearing a secondary O‐alkyl group.
ChemInform Abstract: Divergent Reaction Pathways of Homologous and Isosteric Propargyl Amides in Sequential Ru/Pd‐Catalyzed Annulations for the Synthesis of Heterocycles.
Authors: Raikar Sandeep N. , Malinakova Helena C. 
Published: August 2013

AbstractThe divergent reaction pathway includes a Cu‐catalyzed three‐component reaction, a ring closing metathesis (RCM) and a Heck cyclization.
ChemInform Abstract: P‐Arylation: Arynes to Aryl‐Phosphonates, ‐Phosphinates, and ‐Phosphine Oxides.
Authors: Dhokale Ranjeet A. , Mhaske Santosh B. 
Published: August 2013

AbstractThe reaction proceeds under metal‐free conditions and is efficient, regioselective, and general.
ChemInform Abstract: New Diketopiperazine Derivatives from Culture Broth of Staphylococcus sp. Isolated from Corallina officinalis Lineaus.
Authors: Khedr Amgad I. M. , Kouno Isao , Tanaka Takashi , Yamada Koji 
Published: August 2013

AbstractThe two new diketopiperazine derivatives staphyloamides A (Ia) and B (Ib) are isolated from the culture broth of Staphylococcus sp.
ChemInform Abstract: Two New Furofuran Lignans from Kandelia obovata.
Authors: Nan Haihan , Lin Han , Qian Zhuoquan , Yin Haozhen 
Published: August 2013

AbstractThe two new furofuran lignans kandelisesquilignan A (Ia) and B (Ib) are isolated from the aerial part of Kandelia obovata.
ChemInform Abstract: New Xanthones from Garcinia bracteata and Their Cytotoxicities.
Authors: Hu Qiufen , Niu Deyun , Li Xiangli , Qin Yunhua , Yang Zongyan , Zhao Guoli , Yang Zhongxiu , Gao Xuemei , Chen Zhangyu 
Published: August 2013

AbstractTwo new xanthones, bracthone A (Ia) and B (Ib), are isolated from the stems of Garcinia bracteata together with four known xanthones.
ChemInform Abstract: Advances in the Bestmann—Ohira Reagent‐Assisted Regioselective Synthesis of Substituted Pyrazoles, Triazoles, and Oxazoles
Authors: Mohapatra Seetaram , Bhanja Chittaranjan , Jena Satyaban , Chakroborty Subhendu , Nayak Sabita 
Published: August 2013

AbstractReview: 40 refs.
ChemInform Abstract: Heterocyclization of 1‐ and 2‐Alkynyl‐9,10‐anthraquinones: New Synthetic and Mechanistic Aspects
Authors: Vasilevskiy S. F. , Baranov D. S. 
Published: August 2013

AbstractReview: new data (2005—2012) on the peculiarities and common characteristics of cascade reactions of 1‐ and 2‐alkynyl‐9,10‐anthraquinones with polyfunctional reagents (guanidine, urea, thiourea) and intramolecular heterocyclizations of ortho‐amino derivatives of 1‐ and 2‐alkynyl‐9,10‐anthraquinones; 32 refs.
Identification of Polyproline II Regions Derived From the Proline‐Rich Nuclear Receptor Coactivators PNRC and PNRC2: New Insights for ERα Coactivator Interactions
Authors: Byrne C. , Miclet E. , Broutin I. , Gallo D. , Pelekanou V. , Kampa M. , Castanas E. , Leclercq G. , Jacquot Y. 
Published: August 2013

ABSTRACTProtein–protein interactions are crucial for signal transductions required for cell differentiation and proliferation. Their modulation is therefore key to the development of therapeutic alternatives, particularly in the context of cancer. According to literature data, the polyproline‐rich nuclear receptor coactivators PNRC and PNRC2 interact with estrogen receptor (ERα) through their PxxP SH3‐binding motifs. In a search to identify the molecular features governing this interaction, we explored using electronic circular dichroism (ECD) spectroscopy and molecular dynamics (MD) calculations, the capacity of a range of putative biologically active peptides derived from these proteins and containing this PxxP motif(s) to form polyproline II (PPII) domains. An additional more exhaustive structural study on a lead PPII peptide was also performed using 2D nuclear magnetic resonance (NMR) spectroscopy. With the exception of one of all the investigated peptides (PNRC‐D), binding assays failed to detect any affinity for Grb2 SH3 domains, suggesting that PPII motifs issued from Grb2 antagonists have a binding mode distinct from those derived from Grb2 agonists. Instead, the peptides revealed a competitive binding ability against a synthetic peptide (ERα17p) with a putative PPII‐cognate domain located within a coregulator recruitment region of ERα (AF‐2 site). Our work, which constitutes the first structure‐related interaction study concerning PNRC and PNRC2, supports not only the existence of PxxP‐induced PPII sequences in these coregulators, but also confirms the presence of a PPII recognition site in the AF‐2 of the steroid receptor ERα, a region important for transcription regulation. Chirality 25:628–642, 2013. © 2013 Wiley Periodicals, Inc.
Rational Design of Resorcylic Acid Lactone Analogues as Covalent MNK1/2 Kinase Inhibitors by Tuning the Reactivity of an Enamide Michael Acceptor
Authors: Xu Jin , Chen Anqi , Joy Joma , Xavier Vanessa Joanne , Ong Esther H. Q. , Hill Jeffrey , Chai Christina L. L. 
Published: August 2013

AbstractRecent biological and computational advances in drug design have led to renewed interest in targeted covalent inhibition as an efficient and practical approach for the development of new drugs. As part of our continuing efforts in the exploration of the therapeutic potential of resorcylic acid lactones (RALs), we report herein the design, synthesis, and biological evaluation of conveniently accessible RAL enamide analogues as novel covalent inhibitors of MAP kinase interacting kinases (MNKs). In this study, we have successfully demonstrated that the covalent binding ability of RAL enamides can be tuned by attaching an electron‐withdrawing motif, such as an acyl group, to enhance its reactivity toward the cysteine residues at the MNK1/2 binding sites. We have also shown that 1H NMR spectroscopy is a convenient and effective tool for screening the covalent binding activities of enamides using cysteamine as a mimic of the key cysteine residue in the enzyme, whereas mass spectrometric analysis confirms covalent modification of the kinases. Preliminary optimization of the initial hit led to the discovery of enamides with low micromolar activity in MNK assays. Cancer cell line assays have identified RAL enamides that inhibit the growth of cancer cells with similar potency to the natural product L‐783,277.
A Simple Synthetic Route to Obtain Pure Trans‐Ruthenium(II) Complexes for Dye‐Sensitized Solar Cell Applications
Authors: Barolo Claudia , Yum Jun‐Ho , Artuso Emma , Barbero Nadia , Di Censo Davide , Lobello Maria Grazia , Fantacci Simona , De Angelis Filippo , Grätzel Michael , Nazeeruddin Mohammed Khaja , Viscardi Guido 
Published: August 2013

AbstractWe report a facile synthetic route to obtain functionalized quaterpyridine ligand and its trans‐dithiocyanato ruthenium complex, based on a microwave‐assisted procedure. The ruthenium complex has been purified using a silica chromatographic column by protecting carboxylic acid groups as iso‐butyl ester, which are subsequently hydrolyzed. The highly pure complex exhibits panchromatic response throughout the visible region. DFT/time‐dependent DFT calculations have been performed on the ruthenium complex in solution and adsorbed onto TiO2 to analyze relative electronic and optical properties. The ruthenium complex endowed with the functionalized quaterpyridine ligand was used as a sensitizer in dye‐sensitized solar cell yielding a short‐circuit photocurrent density of more than 19 mA cm−2 with a broad incident photon to current conversion efficiency spectra ranging from 400 to 900 nm, exceeding 80 % at 700 nm.
Efficient Dye‐Sensitized Solar Cells Using a Tetramethylthiourea Redox Mediator
Authors: Liu Yeru , Jennings James R. , Wang Qing 
Published: August 2013

AbstractAn organic redox couple tetramethylthiourea/tetramethylformaminium disulfide (TMTU/TMFDS2+) is evaluated in dye‐sensitized solar cells in conjunction with a series of indoline and ruthenium‐based dyes. Of these, devices with indoline dye D205 show the best performance, with an optimized power conversion efficiency of 7.6 % under AM 1.5G 1 sun illumination. Charge collection and injection are highly efficient in all TMTU‐based DSCs studied. Regeneration of indoline dyes is highly efficient, whereas regeneration of ruthenium dyes by TMTU is less efficient, accounting for their inferior performance. Impedance spectroscopy results reveal that using an optimized TMTU/TMFDS2+ electrolyte solution, the TiO2 conduction band edge is 300–400 meV lower than when an optimized I3−/I− electrolyte is used. The would‐be loss in open‐circuit voltage caused by the downward conduction band shift is mostly compensated by approximately the 200 meV lower redox level of the TMTU/TMFDS2+ electrolyte and up to 1000 times slower recombination rates. This makes TMTU/TMFDS2+ a promising redox couple in the development of highly efficient solar energy conversion devices.
Au@Pd Core–Shell Nanobricks with Concave Structures and Their Catalysis of Ethanol Oxidation
Authors: Wang Wenjin , Zhang Jie , Yang Shengchun , Ding Bingjun , Song Xiaoping 
Published: August 2013

AbstractAu@Pd core–shell nanobricks (CNBs) with concave surfaces and Pd shells with a thickness of approximately 5 nm were synthesized by co‐reduction of HAuCl4 and H2PdCl4 in the presence of Au seeds and Ag ions. These as‐synthesized concave CNBs exhibit significantly enhanced catalytic activity for the electrooxidation of ethanol in alkaline media compared to the commercially‐used Pd black. The improved performance of the Au@Pd CNBs can be attributed to the exposed stepped surfaces, high‐index facets, and the synergistic effects of the core and shell metals.
Assessing FRET using spectral techniques
Authors: Leavesley Silas J. , Britain Andrea L. , Cichon Lauren K. , Nikolaev Viacheslav O. , Rich Thomas C. 
Published: August 2013

AbstractFörster resonance energy transfer (FRET) techniques have proven invaluable for probing the complex nature of protein–protein interactions, protein folding, and intracellular signaling events. These techniques have traditionally been implemented with the use of one or more fluorescence band‐pass filters, either as fluorescence microscopy filter cubes, or as dichroic mirrors and band‐pass filters in flow cytometry. In addition, new approaches for measuring FRET, such as fluorescence lifetime and acceptor photobleaching, have been developed. Hyperspectral techniques for imaging and flow cytometry have also shown to be promising for performing FRET measurements. In this study, we have compared traditional (filter‐based) FRET approaches to three spectral‐based approaches: the ratio of acceptor‐to‐donor peak emission, linear spectral unmixing, and linear spectral unmixing with a correction for direct acceptor excitation. All methods are estimates of FRET efficiency, except for one‐filter set and three‐filter set FRET indices, which are included for consistency with prior literature. In the first part of this study, spectrofluorimetric data were collected from a CFP–Epac–YFP FRET probe that has been used for intracellular cAMP measurements. All comparisons were performed using the same spectrofluorimetric datasets as input data, to provide a relevant comparison. Linear spectral unmixing resulted in measurements with the lowest coefficient of variation (0.10) as well as accurate fits using the Hill equation. FRET efficiency methods produced coefficients of variation of less than 0.20, while FRET indices produced coefficients of variation greater than 8.00. These results demonstrate that spectral FRET measurements provide improved response over standard, filter‐based measurements. Using spectral approaches, single‐cell measurements were conducted through hyperspectral confocal microscopy, linear unmixing, and cell segmentation with quantitative image analysis. Results from these studies confirmed that spectral imaging is effective for measuring subcellular, time‐dependent FRET dynamics and that additional fluorescent signals can be readily separated from FRET signals, enabling multilabel studies of molecular interactions. © 2013 International Society for Advancement of Cytometry
MR‐tree: an efficient index for MapReduce
Authors: Li Chunsheng , Chen Jie , Jin Cheqing , Zhang Rong , Zhou Aoying 
Published: August 2013

SUMMARYNowadays, big data becomes more and more popular, because it widely exists in many applications, such as social network and astronomy. Although building indexes to improve the query processing performance is common in DBMS field, it is infeasible to apply traditional indexing techniques to the MapReduce framework efficiently. Thus, how to process such data efficiently is challenging. In this paper, we study the problem of how to build an index for multidimensional data in MapReduce platform. The experimental results show that the proposed method can run efficiently. Copyright © 2013 John Wiley & Sons, Ltd.