bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bioinformatic Strategy for Investigating the Mechanism of Hispolon in the Treatment of Triple-Negative Breast Cancer Combined with In vitro Experiments
Authors: Li Junfeng , Bao Jingfei , Wu Lichao , Sun Tengfei , Zhao Junhui , Luo Fei , Tao Fangfang , Liu Wenhong 
Published: August 2024

Background:
Hispolon, a phenolic compound isolated from the medicinal yellow fungal mulberry, exhibits a strong anti-triple-negative breast cancer (TNBC) effect. However, the antitumor mechanisms of Hispolon have not been fully explored.

Objective:
In this study, we systematically investigated the mechanism of Hispolon against TNBC based on bioinformatics and in vitro experiments.

Methods:
The Hispolon-related targets were first collected from the SwissTarget database. Differential Expression Genes (DEG) were screened between TNBC and normal breast tissue using the Gene Expression Comprehensive (GEO) dataset. The overlapping targets between Hispolon and DEG were analyzed by plotting Venn maps. Protein-protein interaction (PPI) network was constructed to analyze the interactions among these targets. The focus was on mining the core targets of anti-TNBC effects of Hispolon via the Cytohubba and MCODE plugin of Cytoscape 3.7.2 software. We performed survival analysis on these core targets to screen the best-matched targets, including EGFR, KIT, and PLAU. This correlated strongly with our validation of Hispolon by molecular docking. In addition, Gene Ontology (GO) anal-ysis and KEGG pathway analysis were performed using R software (ClusterProfiler package). Finally, in vitro experiments were performed to assess the accuracy of predicted target genes.

Results:
The ADME results suggested that Hispolon has great potential to develop into a drug. Twenty overlapping targets were screened by matching the 107 targets of Hispolon to the 2,013 targets of TNBC DEG. Seven core targets of Hispolon against TNBC were initially identified, including EGFR, IGFBP3, MMP9, MMP2, MMP1, PLAU, and KIT. GO enrich-ment analysis demonstrated that the biological process of Hispolon acting on TNBC mainly involves lymphocyte activation in immune response and phosphatidylinositol-mediated signal-ing. Additionally, the relaxin signaling pathway, estrogen signaling pathway, proteoglycans in cancer, and others might be the key pathways of Hispolon against TNBC. Furthermore, Hispo-lon inhibited the proliferation of MDA-MB-231 cells in a concentration-dependent manner and regulated the RNA and protein expression of the core targets EGFR, PLAU, and KIT for the treatment of TNBC.

Conclusion:
In this study, the polygenic pharmacological mechanism of action of Hispolon against TNBC was explored through network pharmacology and in vitro experiments, provid-ing a new insight into the mechanism of TCM monomer against TNBC.
Exosomal CircRNAs: A Future Star in Colorectal Cancer
Authors: Zhou Yuanzhi , Wei Chengyan , Xu Yuqi , Wang Jingjing , Zhang Chunwei , Jin Yong 
Published: August 2024

Abstract:
Colorectal cancer (CRC) is currently the third most common malignancy world-wide, with an increasing mortality rate and treatment resistance. Due to the lack of effective biomarkers and therapeutic targets, the early diagnosis and treatment of colorectal cancer re-main suboptimal. Circular RNAs (circRNAs) are a novel class of non-coding RNAs with co-valent closed-loop structures that are well stabilized and conserved and are involved in multi-ple pathological conditions in humans. CircRNAs have been identified to be enriched and sta-ble in exosomes. In addition, there is growing proof that exosomal circRNAs that have been identified as oncogenes or tumor suppressors regulate CRC growth, migration, and sensitivity to radiotherapy and chemotherapy. Exosomal circRNAs represent promising candidates as di-agnostic biomarkers and anti-tumor targets. In this article, we explore recent studies on exo-somal circRNAs in CRC and describe their biological functions in colorectal cancer develop-ment, illustrating their potential as biomarkers and targeted therapeutic capabilities.
Recent Advances in the Synthesis of Antioxidant Derivatives: Pharmacological Insights for Neurological Disorders
Authors: Singh Kuldeep , Gupta Jeetendra Kumar , Sethi Pranshul , Mathew Sojomon , Bhatt Alok , Sharma Mukesh Chandra , Saha Sunam , Shamim  , Kumar Shivendra 
Published: August 2024

:
Neurological disorders, characterized by oxidative stress (OS) and inflammation, have
become a major global health concern. Redox reactions play a vital role in regulating the balance
of the neuronal microenvironment. Specifically, the imbalance leads to a significant weakening of
the organism's natural defensive mechanisms. This, in turn, causes the development of harmful
oxidative stress, which plays a crucial role in the onset and progression of neurodegenerative diseases.
The quest for effective therapeutic agents has led to significant advancements in the synthesis
of antioxidant derivatives. This review provides a comprehensive overview of the recent
developments in the use of novel antioxidant compounds with potential pharmacological applications
in the management of neurological disorders. The discussed compounds encompass a diverse
range of chemical structures, including polyphenols, vitamins, flavonoids, and hybrid molecules,
highlighting their varied mechanisms of action. This review also focuses on the mechanism
of oxidative stress in developing neurodegenerative disease. The neuroprotective effects of these
antioxidant derivatives are explored in the context of specific neurological disorders, including
Alzheimer's disease, Parkinson's disease, and Huntington's disease. The ultimate goal is to provide
effective treatments for these debilitating conditions and improve the quality of life for patients.
A Comprehensive Review on the Development of Titanium Complexes as Cytotoxic Agents
Authors: Kumar Nitesh , Kaushal Raj , Awasthi Pamita 
Published: August 2024

:
After the discovery of cis-platin, the first metal-based anticancer drugs, budotitane, and
titanocene dichloride entered clinical trials. These two classes of complexes were effective against
those cell lines that are resistant to cis-platin and other platinum-based drugs. However, the main
limitation of these complexes is their low hydrolytic stability. After these two classes, a third generation
titanium based complex, i.e. diaminebis(phenolato)bis(alkoxo) titanium(IV), was invented,
which showed more hydrolytic stability and high cytotoxicity than budotitane and titanocene
dichloride. The Hydrolytic stability of complexes plays an important role in cytotoxicity. Earlier
research showed that hydrolytically less stable complexes decompose rapidly into non-bioavailable
moiety and become inactive. The mechanism of Ti(IV) complexes of diaminebis(phenolato)
bis(alkoxo) is under investigation and is presumed to involve Endoplasmic Reticulum (ER)
stress, which leads to apoptosis. The proposed mechanism involves the removal of ligands from
the titanium complex and the binding of the Ti center to transferrin protein and its release inside
the cell. Also, the structure of the ligand plays a key role in the cytotoxicity of complexes; as the
bulkiness of the ligand increased, the cytotoxic nature of complexes decreased.
Posterior Reversible Encephalopathy Syndrome Associated with L-Asparaginase Treatment in Children: Literature Review and Six Case Reports
Authors: Tosta Pérez María Margarita , Belen Lisandra Herrera , Pessoa Adalberto , Avendaño Jorge Farías 
Published: August 2024

Abstract:
L-asparaginase (L-ASNase) is an enzyme that shows targeted activity against Acute
Lymphoblastic Leukemia (ALL) and similar lymphoid neoplasms by facilitating the breakdown
of asparagine into L-aspartic acid, thereby reducing L-asparagine levels in leukemic cells. However,
its therapeutic potential is hindered by its associated toxicity, leading to complications,
such as thrombosis, hemorrhage, thrombocytopenia, fibrinolysis, hypersensitivity reactions, and
the development of Posterior Reversible Encephalopathy Syndrome (PRES). This review compiles
documented cases of PRES linked to treating B and T cell acute lymphoblastic leukemia in
children using L-ASNase. Although this pathology is rare, understanding its management is crucial
within ASNase-based chemotherapy protocols. As PRES lacks a specific treatment, focusing
on symptomatic management becomes pivotal. Therefore, comprehending the underlying causes
during L-ASNase treatment for acute lymphoblastic leukemia is essential. Understanding the etiology
and clinical symptoms of this illness is critical for early diagnosis and treatment.
The cases of PRES described in this review include instances in which this syndrome has appeared
after the administration of L-ASNase in children. In some cases, PRES developed during
induction therapy, while in others, it occurred during the reinduction phase. These cases resolved
days after discontinuation of L-ASNase. The findings suggest a close relationship between drug
administration and the appearance of brain lesions, as evidenced by the disappearance or decrease
of these lesions when the drug was eliminated from the bloodstream.
Technology transfer as a tool for managing the regional innovation economy
Authors: Belyaeva E. S. , Sotnikov A. A. , Tkacheva T. U. 
Published: August 2024

Relevance. The Russian economy is moving to a new innovative level of development, and actively implemented projects in the field of digital transformation form the basis for creating a long-term and secure information and telecommunications infrastructure capable of providing high-speed transmission, processing and storage of large amounts of data, which will be available to a wide range of enterprises.The purpose of the study is to identify the role of technology transfer in the management of the regional innovation economy and current trends.Objectives: to study the indicators of Internet use by the population for ordering goods and services in urban and rural areas; to assess the dynamics of gross value added of the ICT sector and GDP; to assess the demand of economic and social sectors for digital technologies; to propose ways to solve these problems of digitalization of Russian enterprises.Methodology. The methods of system analysis, deduction and induction, analysis and synthesis are used.Results. Russian enterprises are experiencing significant difficulties in the process of technology transfer to the digital space due to the lack of deep readiness to accept and use open innovations, as well as due to restrictions on the free exchange of intellectual property results and insufficient level of asset sharing. These factors can slow down the pace of technology transfer of enterprises and create obstacles to their competitiveness in today's digital business environment. It is necessary to actively develop technology transfer mechanisms that promote the exchange of knowledge and resources in order to increase efficiency to the new challenges of the digital economy.Conclusions. Economic measures of technology transfer, including bans on access to foreign digital products and services, have not only negative consequences. Currently, consumers in Russia who are accustomed to using digital solutions from foreign manufacturers are faced with the need to switch to domestic analogues of technology as a result of the restrictions imposed.
A study of the peculiarities of freelance activity of the Russian population on online labor market platforms
Authors: Alyokhina O. F. , Beilina A. F. , Trufanova S. A. , Bashlykov T. V. 
Published: August 2024

Therelevanceofthestudyisdeterminedbythe emergence and consolidation of new trends in the implementation of labor activity of the population in the context of digitalization and new challenges, as well as the need for their comprehensive study.Thepurposeofthe study is to study the peculiarities of freelance activity of the Russian population on online labor market platforms, as well as to identify a set of measures necessary to obtain benefits from the implementation of this type of activity in order to stabilize the labor market during a period of change and reduce social tension.TheobjectivesofthestudyarerelatedtotheanalysisofsupplyanddemandfortheservicesofRussianfreelancersoninternationalonlinelabormarketplatforms,includingbycomparingitspositions with other countries; identifying measures to optimize the activities of online freelancers and stabilize the labor market during the period of change.Methodology.Theresearchwasimplementedusingthe method of collecting information from open Internet sources, tabular and graphical methods, the method of economic analysis, analysis and synthesis, systematization, comparison, logical method and systematic approach.Results.ItisdeterminedthatthefreelanceactivityoftheRussianpopulationintheonlineformathasgreatgrowthpotential.Theprerequisitesforthedevelopmentofonlinefreelancingarehighlighted,aswellasthemotivesforRussianspecialistsenteringthedigitalplatformsofthegloballabormarket.Theanalysisofthesupplyanddemandofonlinefreelancersonthelargestonlineemploymentplatformsintheperiod2017-2022wascarriedout.ThespecificsofRussiaarerevealedincomparisonwiththetrendstypicalforChina, India, Germany, Great Britain and the USA.Conclusion.Theconclusionismadeaboutthe high activity of Russian freelancers on the online platforms of the global labor market, about the predominantly growing dynamics of this market segment, as well as about the existing restrictions in this area, which can be overcome by greater support from the state.
Voluntary initiatives of non-profit organizations in the formation of creative communities and creative spaces of the city: a philosophical view
Authors: Kasatkina S. S. , Aula E. R. 
Published: August 2024

Relevance.Thisarticleexaminesthe topical issue of the role of the non-profit sector in urban development from a philosophical point of view. The authors cite key concepts that reveal the socio-legal aspects of the work of NGOs; define the socio-philosophical significance of the activities of non-profit organizations in Russian cities.Thepurposeofthe study is to identify the impact of volunteer initiatives of the non-profit sector on the development of creative locations of cities, the dynamics of territorial development.Objectives:todeterminingthe relationship of NGOs with the development of the creative potential of the city; socio-philosophical analysis of competitive materials of applications from non-profit organizations to civil society development funds; identification of directions for the formation of urban creative and innovative spaces created with the help of NGOs.Methodology.Theworkusesa systematic method, an analytical review and synthesis of the information under study. The authors used materials from open data reports on the evaluation of the results of the projects of the winners of the competitions for grants from the President of the Russian Federation for the development of civil society in 2022.Results.Theresultisanideaofthe socio-cultural modernization of the urban sphere. Initiative in the implementation of voluntary urban socially significant projects forms the sustainability of urban living conditions, the investment and image attractiveness of the city, and the positive migration issue. The interrelation between initiative projects of representatives of the non-profit sector and socio-cultural design of the environment, activation of the creative class, and improvement of the comfort level of urban areas is revealed. Modern active NGOs in Russian cities represent the avant-garde, implementing creative projects and broadcasting cultural trends, creative practices that define the conceptual meanings of the development of a particular city (region). Projects based on the voluntary aspirations of citizens and related to the assistance of specific social groups acquire a sustainable character of development and form the features of the city.Conclusion.Theresultsofthe study showed that the work of the non-profit sector in Russian cities is transforming urban spaces by developing creative resources and creative industries.
Artificial intelligence in state and municipal management: challenges and prospects
Authors: Belyaeva O. V. , Sokolova A. Y. 
Published: August 2024

Relevance. In the modern world, artificial intelligence (AI) is one of the fastest growing areas of information technology, which is increasingly penetrating into various spheres of human activity. In the context of public and municipal management, AI is a technology that is able to automate and optimize work processes, improve the quality of services provided to citizens, and increase the level of security and transparency of government work.The purpose is to analyze the possibilities and risks of using artificial intelligence in state and municipal management, as well as to determine the prospects for its development in this area.Objectives: to analyze the advantages of using artificial intelligence in state and municipal management; to study the risks and challenges associated with its implementation; to analyze trends in the development of artificial intelligence in this area, as well as to determine the prospects for its use.Methodology. Empirical, theoretical, statistical and graphical representation methods were used in the course of scientific research.Results. The study revealed the advantages of AI in public administration (improving efficiency, improving the quality of services, transparency, security); risks and challenges were studied (lack of infrastructure, risk of privacy violations, problems of transparency of algorithms, risk of discrimination); trends in the development of AI were analyzed (e-government, optimization of workflows, personalization of services, monitoring of social media, security); the prospects of using AI (smart cities, virtual assistants, hybrid systems, decision support, cooperation with business, international cooperation) have been identified.Conclusions. Artificial intelligence can significantly improve the efficiency and quality of public and municipal administration. However, for the successful implementation of AI, it is necessary to solve problems such as the lack of infrastructure and qualified specialists, ensuring data security, transparency of algorithms and compliance with the regulatory framework. To do this, it is necessary to conduct further research, develop integrated approaches and take into account world experience. The prospects for using AI include the creation of smart cities, the use of virtual assistants, hybrid systems, decision support systems, business cooperation and international cooperation.
Dynamics of development of consumer preferences and behavioral patterns of generation Z in the digital economy
Authors: Lapidus L. V. , Gostilovich A. O. , Zhiburt P. E. , Karaseva M. O. , Samokhvalova E. I. , Kozlova E. D. 
Published: August 2024

Relevance.In2023,representativesofGenerationZ entered into active competition in the labor market and began to increase their marketing potential, which made this segment of consumers attractive to companies from different fields. Marketers and business development managers continue to study the consumer preferences and behavioral patterns of Generation Z, born in the digital age.Thepurposeofthe study is to study the dynamics of the development of consumer preferences and behavioral patterns of generation Z in the digital economy.Objectives:tostudythe dynamics of consumer behavior in the field of e-commerce and methods of online and offline payment; to study the dynamics of consumer preferences of generation Z in the field of reading information from electronic devices.Methodology.A questionnaire of 37 questions has been developed, divided into 4 groups. 300 respondents from Generation Z living in Moscow and the Moscow region took part. The answers were collected using the Google Forms online resource. The study was conducted at the Faculty of Economics of Lomonosov Moscow State University in the Laboratory of Applied Industry Analysis under the supervision of Professor L. V. Lapidus.Results.Itwas revealed that from 2019 to 2022, the proportion of respondents who prefer non-cash payment methods increased significantly. The proportion of respondents who pay for purchases online has also increased. The proportion of Generation Z representatives is growing, who find it more convenient to pick up purchases from order pick-up points than to deliver via courier.Conclusions.identificationoftrends in the development of consumer habits and behavioral patterns: the growth of consumption in online stores and marketplaces; minimization of communications in the "person-to-person" system when paying and receiving online purchases; multiscreen a combination of devices of different types to solve everyday tasks. Based on the results and conclusions of the study, recommendations were formulated for companies engaged in various types of interaction with representatives of Generation Z.
A Comparative Study on the Use of Evaluative That Patterns in Abstracts by Expert and Novice Writers
Authors: Feng Linhao 
Published: August 2024

This study investigates the differences in how expert and novice writers use evaluative that-complement clauses in abstracts. The research analyzed 150 research article abstracts and 100 master’s thesis abstracts in the social sciences, applying the model of “evaluative that patterns” with the assistance of the MAXQDA annotation tool and ChatGPT retrieval mode. The analysis reveals that both groups often use this pattern to present their findings, typically attributing evaluations to abstract sources. They primarily express epistemic stances through verbal predicates. However, experts demonstrate significantly greater use of every element (entity, source, stance, and expression) of this feature. Experts are more inclined to use human resources and discourse act verbs and prefer to evaluate prior studies and methods, expressing more tentative stances to foster a dialogic space. These findings suggest that expertise influences rhetorical strategies for evaluating research materials. The study highlights pedagogical implications, offering valuable insights for novice writers in the social sciences to help them understand how to effectively use linguistic resources to convey evaluative claims and establish authoritative authorial stances.
Validitas dan Reliabilitas Status Epilepticus Severity Score Bahasa Indonesia
Authors: Pratiwi Astri Dewina , Budikayanti Astri , Wiratman Winnugroho , Octaviana Fitri 
Published: August 2024

Status Epilepticus Severity Score (STESS) merupakan instrumen untuk memprediksi luaran pasien status epileptikus (SE) sebelum dilakukan tatalaksana. STESS sudah divalidasi sebelumnya di Swiss dengan nilai titik potong > 4 berkorelasi dengan luaran yang buruk. Tujuan utama penelitian ini untuk menilai validitas dan reliabilitas STESS yang telah diterjemahkan ke dalam Bahasa Indonesia (STESS-INA). Tujuan tambahan untuk melihat hubungan antara nilai STESS dengan luaran. Kuesioner STESS diterjemahkan ke dalam Bahasa Indonesia dan dilakukan uji validitas dan reliabilitas. Desain penelitian ini adalah potong-lintang prospektif dimana dilakukan penilaian secara serial untuk melihat luaran pada 24 dan 48 jam pertama, serta hari ke-7, ke-30 dan akhir perawatan. Luaran yang dinilai adalah hidup dan mati. Titik potong STESS-INA ditentukan berdasarkan kurva receiver operating characteristic (ROC). Terdapat 17 pasien yang memenuhi kriteria inklusi. Hasil uji validitas interna STESS-INA koefisien korelasi 0,484 hingga 0,702 dengan nilai Cronbach’s Alpha 0,71. Nilai area under curve (AUC) STESS-INA pada akhir perawatan 96,2%. Nilai titik potong STESS-INA >4 dan berhubungan bermakna dengan luaran kematian pada akhir perawatan (p=0,006). STESS-INA merupakan instrumen valid dan reliabel untuk memprediksi luaran pasien SE. Nilai STESS-INA > 4 berhubungan bermakna terhadap luaran kematian pada akhir perawatan pasien SE.