bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathological PCI as a prognostic marker of survival after neoadjuvant chemotherapy in patients undergoing interval cytoreduction with or without HIPEC in FIGO stage IIIC high grade serous ovarian cancer
Authors: Sinukumar Snita , Damodaran Dileep , S. Deepika , Piplani Sanjay 
Published: August 2024

ObjectiveTo determine the best possible value of pathological PCI (pPCI) as a prognostic marker for survival in high-grade serous epithelial ovarian cancer patients in patients treated with neoadjuvant chemotherapy and interval cytoreductive surgery.MethodsAll patients with FIGO stage IIIC high-grade serous ovarian carcinoma were included. Receiver operating curves (ROC) were used to determine the best possible score for pPCI in predicting survival. Survival curves were calculated using the Kaplan–Meier test, and factors affecting survival were compared using the log-rank test.ResultsFrom January 2018 to January 2024, 171 patients who underwent interval cytoreductive surgery were included. Complete cytoreduction was achieved in 88% of the patients. ROC curves determined a (pPCI) cut-off value of 8 as the best possible score for predicting survival with a sensitivity of 82% and specificity of 67% (Youden’s Index = 0.60). pPCI with a cut-off value of 8 showed improved OS (p = 0.002) and DFS, (p = 0.001) in both univariate and multivariate analyses.ConclusionFollowing interval cytoreductive surgery, despite optimal complete cytoreductive surgery, a pathological PCI of 8 is a poor prognostic indicator of survival and may serve as a surrogate clinical marker for guiding clinicians in adjuvant treatment, especially in resource-driven settings in the real world.
Theophylline impact on weaning in oxygen-dependent infants followed in an outpatient Kangaroo Program
Authors: Montealegre-Pomar Adriana , Charpak Nathalie , Lince-Rivera Catalina 
Published: August 2024

BackgroundTheophylline was an orally administered xanthine used for treatment of apnea of prematurity and Bronchopulmonary Dysplasia in ambulatory follow-up of Low-Birth-Weight infants (LBWI) with oxygen-dependency in the outpatient Kangaroo Mother Care Program (KMCP). Theophylline's main metabolic product is caffeine; therefore, it was an alternative due to the frequent lack of ambulatory oral caffeine in low and middle-income countries.ObjectiveTo assess the effectiveness of oral theophylline in decreasing days with oxygen and to describe frequency of adverse related events.MethodsQuasi-experiment before and after withdrawal of theophylline given systematically to LBWI with ambulatory oxygen in two KMCPs.Results729 patients were recruited; period 1: 319 infants when theophylline was given routinely and period 2: 410 infants when theophylline was no longer used. The theophylline cohort had less gestational age, less weight at birth, more days in Neonatal Intensive Care Unit, more days of oxygen-dependency at KMCP admission, and more frequencies of Intrauterine Growth Restriction and apneas. After adjusting with propensity score matching, multiple linear regression showed that nutrition was associated with days of oxygen-dependency, but theophylline treatment not. No differences were found in frequencies of readmissions up to 40 weeks, intraventricular hemorrhage or neurodevelopmental problems. Participants in period 2 had more tachycardia episodes.ConclusionsWe did not find association between oral theophylline treatment and the reduction of days with ambulatory oxygen. For the current management of oxygen-dependency in LBW infants, the importance of nutrition based on exclusive breast feeding whenever possible, is the challenge.
Effects of transparent online open procurement on prices, volumes, and costs of medicines: an interrupted time series study in Ningxia, China
Authors: Gao Jingying , Liu Chaojie , Li Yinming , Chen Xizhuo , Xue Tianqin , Tang Yuqing 
Published: August 2024

ObjectivesTo assess the effects of the transparent online open procurement arrangement on the prices, volumes, and costs of medicines in Ningxia, China.MethodsData were extracted from the Ningxia pharmaceutical procurement platform, covering 16 months of purchase orders (December 2019 to March 2021) prior to the implementation of the transparent online open procurement policy and 20 months of purchase orders after the implementation of the policy (April 2021 to November 2022). Interrupted time series (ITS) analysis was performed to evaluate the effects of the transparent online open procurement policy on the prices, volumes, and total costs of the purchase orders.ResultsAfter implementation of the transparent online open procurement policy, the average price of purchased medicines showed a declining trend by 0.012 Yuan per month, while the total volume of purchase orders declined at a rate by 1.741 million per month measured by the smallest formulation units and the total costs of the purchase orders decreased at a rate by 5.525 million Yuan per month.ConclusionThe transparent online open procurement policy resulted in reduced prices, lowered volumes, and lowered total costs of purchased orders of medicines.
Effects of three flavonoids on the metabolism of lenvatinib
Authors: Yang Jinzhao , Chen Jie , Li Qingqing , Xu Ren-ai , Chen Xiaohai 
Published: August 2024

Lenvatinib is a first-line therapy for the treatment of hepatocellular carcinoma (HCC), an active multi-target tyrosine kinase inhibitor (TKI). The interaction between Traditional Chinese Medicine (TCM) and chemicals has increasingly become a research hotspot. The objective of this study was to pinpoint the effects of three flavonoids on the metabolism of lenvatinib. Enzyme reaction system was established and optimized in vitro, and in vivo experiments were conducted in Sprague-Dawley (SD) rats, where the analytes were detected by ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). We found that among three flavonoids, luteolin and myricetin had strong inhibitory effects on lenvatinib metabolism, with half-maximal inhibitory concentration (IC50) values of 11.36 ± 0.46 µM and 11.21 ± 0.81 µM in rat liver microsomes (RLM), respectively, and 6.89 ± 0.43 µM and 12.32 ± 1.21 µM in human liver microsomes (HLM), respectively. In Sprague-Dawley rats, the combined administration of lenvatinib and luteolin obviously expanded the exposure to lenvatinib; however, co-administered with myricetin did not have any changes, which may be due to the poor bioavailability of myricetin in vivo. Furthermore, the inhibitory type of luteolin on lenvatinib showed an un-competitive in RLM and a mixed in HLM. Collectively, flavonoids with liver protection, especially luteolin, may inhibit lenvatinib metabolism in vitro and in vivo.
Temporal changes in the physical fitness of Chinese adolescents aged 13-18 years: an analysis of eight national successive surveys over three decades
Authors: Ruan Hui , Tang Ruolan 
Published: August 2024

ObjectiveThe aim of this study was to assess temporal changes in physical fitness of Chinese adolescents aged 13–18 years from 1985 to 2019.MethodsBody size /composition and physical fitness indicators, including body height, weight, body mass index (BMI), speed, power, flexibility, muscular endurance, and cardiorespiratory fitness (CRF), were selected from Chinese boys and girls aged 13–18 years from eight Chinese National Surveillance on Students’ Constitution and Health from 1985 to 2019. Temporal changes in means were estimated by sample-weighted linear regression at the test × sex × age level, and national trends were estimated by a post-stratification population weighting procedure.ResultsOverall mean body height, weight and BMI increased significantly for Chinese adolescents over 34 years. There was a small improvement for boys in speed (Effect size [ES] = −0.21, 95% confidence interval [CI] = −0.44 ~ 0.02), a small improvement for boys in power (ES = 0.24, 95% CI = −0.20 ~ 0.69), a small improvement for girls in flexibility (ES = 0.45, 95% CI = 0.15 ~ 0.76), a moderate decline for boys (ES = -0.53 95% CI = −0.84 ~ −0.21) and a moderate improvement for girls (ES = 0.61, 95% CI = −0.03 ~ 1.26) in muscular endurance, and large declines in cardiorespiratory fitness (CRF) for boys (ES = 0.93, 95% CI = 0.64 ~ 1.21) and girls (ES = 0.93, 95% CI = 0.58 ~ 1.27) from 1985 to 2019. These trends in each component of fitness were more positive for adolescents aged 13–15 years than that of adolescents aged 16–18 years in both sexes, except for girls in flexibility.ConclusionThe decline in CRF was most pronounced among Chinese children and adolescents from 1985 to 2019, suggesting a future decline in population health that needs attention.
Smooth control strategy for emergency switching of multi-port flexible interconnected distribution system modes
Authors: Pang Dan , Yin Yu , Wang Zhipeng , Ge Jinming , Wang Wei , Wang Zhenhao , Yi Hongyin , Zhuang Yan 
Published: August 2024

IntroductionWith the rise of distributed energy resources, the interconnection of distribution networks and Flexible Multi-State Switch (FMSS) has become a key technology in the construction of new distribution networks. FMSS plays a significant role in enhancing the reliability and flexibility of the system.MethodsThis paper investigates the impact of mode-switching in FMSSs on voltage shocks, current shocks, and power fluctuations in the event of a feeder fault in a multi-port flexible interconnected distribution system. Firstly, an improved state-tracking control method is proposed to effectively mitigate these impacts. Secondly, for feeder faults connected to the fixed DC bus voltage (Udc-Q) control port, a reselection method for the Udc-Q control port at the main station is introduced, aiming to select the optimal port to maintain the stability of the DC bus voltage.ResultsSimulation experiments have validated the effectiveness of the proposed control method in reducing voltage and current shocks as well as power fluctuations. Additionally, the proposed control strategy has demonstrated an enhancement in the safe and stable operation of the system under emergency fault conditions.DiscussionThe control strategy presented in this paper is capable of addressing the challenges posed by feeder faults and ensuring the stability of the DC bus voltage and reliable power supply to feeder loads, thereby enhancing the overall performance and reliability of the flexible interconnected distribution system. The research findings have been verified on the MATLAB/Simulink simulation platform.
Delivering project SCORE in competitive youth sport settings
Authors: Ferreira Marta , Santos Fernando , Fernández-Villarino María A. , Mergler Jason , Strachan Leisha , MacDonald Dany J. 
Published: August 2024

IntroductionThis study evaluates the effectiveness of the Project SCORE intervention in fostering Positive Youth Development (PYD) within competitive youth sport settings in Portugal. Project SCORE is an online PYD-focused tool developed to assist coaches in promoting the 4Cs—competence, confidence, connection, and character—within their coaching.MethodsThe research involved 13 coaches and 70 youth athletes from football and rowing teams. Methodologically, this study analyzed the pre- and post- Project SCORE intervention data, assessing the perceptions of coaches and athletes towards the development of the 4Cs.ResultsResults indicated significant improvements in athletes' perceptions of 4Cs post-intervention, and among coaches' perceptions, there was a significant improvement in the practice and transfer of life skills. Particularly, coaches showed enhanced abilities in fostering life skills and facilitating the transfer of these skills to competitive environments, although some dimensions like sport climate did not sustain positive changes.DiscussionThe findings highlight the benefits of customized PYD-based programs in competitive youth sports and suggest the need for further research to enhance their widespread and consistent implementation.
Immunotherapeutic allogeneic dendritic cell and autologous tumor cell fusion vaccine alone or combined with radiotherapy in canine oral malignant melanoma is safe and potentially effective
Authors: Xia Yuan-Yuan , Liao Albert TaiChing , Liu Ru-Min , Yang Shu-Ya , Kuo Chien-Chun , Ke Chiao-Hsu , Lin Chen-Si , Lee Jih-Jong 
Published: August 2024

IntroductionImmunotherapy represents a promising breakthrough in cancer management and is being explored in canine melanomas. Dendritic cells (DCs) play a crucial role in priming T-cell-mediated immune reactions through the antigen-presenting function. Combining immunotherapy and radiation therapy may generate more substantial anti-cancer efficacy through immunomodulation.ObjectivesOur research reported a preliminary result of the safety and outcome of a kind of immunotherapy, the allogeneic dendritic cell and autologous tumor cell fusion vaccine, alone or in combination with hypofractionated radiation therapy, in canine oral malignant melanoma.MethodsTwo groups of dogs with histopathological diagnoses of oral malignant melanoma were recruited. In group 1 (DCRT), dogs received a combination of DC fusion vaccine and radiotherapy. In group 2 (DC), dogs received DC fusion vaccine alone. DC vaccination was given once every 2 weeks for four doses. Radiotherapy was performed weekly for five fractions. Dogs that received carboplatin were retrospectively collected as a control group (group 3).ResultsFive dogs were included in group 1 (two stage II, three stage III), 11 in group 2 (three stage I/II, eight stage III/IV), and eight (two stage I/II, six stage III/IV) in the control group. Both DC and DCRT were well-tolerated, with only mild adverse events reported, including mucositis, gastrointestinal discomfort, and injection site reactions. The median progression-free intervals in groups 1, 2, and 3 were 214 (95% CI, NA, due to insufficient data), 100 (95% CI, 27–237), and 42 days (95% CI, NA-170), respectively, which were not significantly different. The 1-year survival rates were 20, 54.5, and 12.5% in groups 1, 2, and 3. Dogs in the DCRT group exhibited significantly higher TGF-β signals than the DC group throughout the treatment course, indicating a possible higher degree of immunosuppression.ConclusionThe manuscript demonstrated the safety of dendritic cell/tumor cell fusion vaccine immunotherapy, alone or in combination with radiotherapy. The results support further expansion of this immunotherapy, modification of combination treatment and protocols, and investigation of combining DC vaccine with other treatment modalities.Clinical trial registrationPreclinical Trials, PCTE0000475.
PSYCHOPHYSIOLOGICAL FOUNDATIONS OF THE WORLDVIEW
Authors: Андрущакевич А.А. 
Published: August 2024

Представляется попытка обосновать адекватный путь формирования мировоззрения граждан с использованием методологии и потенциала главной науки о человеке - психофизиологии (в разных её аспектах). Излагаются данные теоретического исследования по выявлению психофизиологических основ мировоззрения. Показана бесперспективность получения позитивного результата в понимании сущности человека с его специфическим сознанием в итоге обобщения накопленных данных. Обсуждаются возможности выполнения исследовательской задачи по раскрытию свойств, механизмов и сущности человеческого сознания. Представляется вероятный вклад психофизиологии как мировоззренческой науки в формирование личности.
An attempt is presented to substantiate an adequate way of forming the worldview of citizens using the methodology and potential of the main science of man - psychophysiology (in its various aspects). The article presents the data of theoretical research to identify the psychophysiological foundations of the worldview. It shows the futility of obtaining a positive result in understanding the essence of a person with his specific consciousness as a result of generalization of the accumulated data. The possibilities of performing a research task to reveal the properties, mechanisms and essence of human consciousness are discussed. The probable contribution of psychophysiology as a world outlook science to the formation of personality is presented.
LONGITUDINAL STUDY IN ADOLESCENT CHARACTER ACCENTUATIONS
Authors: Бартош Т.П. , Бартош О.П. 
Published: August 2024

Под влиянием неблагоприятных климатических, социальных и экономических факторов, связанных с Севером , акцентуации характера могут служить дополнительным фактором уязвимости и приводить к развитию психических и психосоматических расстройств [1-2; 5]. Представляет интерес изучение акцентуаций характера путем наблюдения за подростками-северянами в их разном возрасте.
Under influence of North-related unfavorable climatic, social and economic factors, character accentuations can serve as an additional factor of vulnerability, and develop mental and psychosomatic disorders [1-2; 5]. Of interest is studying character accentuations by monitoring adolescent northerners at their different ages.
PSYCHOLOGICAL SUPPORT FOR PARENTS OF THE BLIND AND VISUALLY IMPAIRED YOUNG CHILDREN
Authors: Быкова Е.Б. , Пузань В.В. 
Published: August 2024

В статье излагаются общие вопросы организации работы психолога с родителями детей со зрительной депривацией. Даётся характеристика постравматической адаптации родителей слепых и слабовидящих детей. Значительное место отведено актуальным проблемам, связанным с особенностями содержательной стороны психологической помощи родителям детей с нарушениями зрения. Представлена специфика групповой работы с родителями в целях создания благоприятного психоэмоционального климата в семьях детей со зрительной депривацией.
The article outlines the general issues of organizing the work of a psychologist with parents of children with visual deprivation. The characteristic of post-traumatic adaptation of parents of blind and visually impaired children is given. A significant place is given to topical problems related to the peculiarities of the content side of psychological assistance to parents of children with visual impairments. The specificity of group work with parents is presented as an aid in creating a favorable psycho-emotional climate in families of children with visual deprivation.
PSYCHOLOGICAL STATE AND QUALITY OF LIFE OF NORTHERN UNIVERSITY STUDENTS DURING AND AFTER THE PERIOD OF DISTANCE LEARNING DURING THE FIRST WAVE OF COVID-19
Authors: Попова М.А. , Щербакова А.Э. , Лакомкина А.С. , Чистова В.В. 
Published: August 2024

В статье представлены результаты исследования психологических реакций и медицинских показателей качества жизни студентов педагогического университета во время и после периода дистанционного обучения в первую волну COVID19. Исследование выполнено на базе научно-исследовательской лаборатории "Здоровый образ жизни и охрана здоровья" в Сургутском государственном педагогическом университете. Общее число респондентов составило 102 человека во время дистанционного обучения (43 юноши и 59 девушек) и 84 человека после периода дистанционного обучения (43 юноши и 41 девушка). Оценивали текущие психические состояния (тревожность, фрустрированность, агрессивность и ригидность), нервно-психическую устойчивость (НПУ), личностный адаптационный потенциал (ЛАП), индивидуально-типологические особенности и показатели качества жизни (КЖ) (физический и психологический компоненты здоровья). По результатам проведённого исследования установлены особенности психологического состояния и медицинских показателей качества жизни у юношей и девушек педагогического университета в период и после дистанционного обучения в первую волну COVID-19.
The article presents the results of a study of psychological reactions and medical indicators of the quality of life of students of the Pedagogical University during and after the period of distance learning in the first wave of COVID-19. The study was carried out on the basis of the research laboratory "Healthy Lifestyle and Health Protection" at the Surgut State Pedagogical University. The total number of respondents was 102 during distance learning (43 boys and 59 girls) and 84 after the distance learning period (43 boys and 41 girls). Current mental states (anxiety, frustration, aggressiveness, and rigidity), neuropsychic stability (NPU), personal adaptive potential (PAP), individual typological characteristics, and quality of life (QoL) indicators (physical and psychological components of health) were assessed. Based on the results of the study, the features of the psychological state and medical indicators of the quality of life in boys and girls of the Pedagogical University during and after distance learning in the first wave of COVID-19 were established. K
FEATURES OF THE REPRODUCTIVE PROFILE IN WOMEN REGULARLY ENGAGED IN FITNESS
Authors: Смелышева Л.Н. , Южакова А.А. 
Published: August 2024

Целью данного исследования является оценка особенностей гормонального репродуктивного профиля у женщин, регулярно занимающихся фитнесом. Интерес представлял гормональный репродуктивный профиль. В результате исследования было установлено, что двигательная активность не влияет на уровень гонадотропинов, но влияет на уровень половых гормонов.
The purpose of this study is to evaluate the features of hormonal reproductive profile in women who regularly engage in fitness. The hormonal reproductive profile was of interest. As a result of the study, it was found that motor activity does not affect the level of gonadotropins, but affects the level of sex hormones.
PERINATAL PERIOD IN HUMAN LIFE AND ITS EXISTENTIAL SIGNIFICANCE
Authors: Краснов А.С. , Меньчиков Г.П. 
Published: August 2024

В статье эксплицируется сущность экзистенциального значения перинатального периода на всех его фазах в жизни человека. Доказывается объективная необходимость адекватной реакции и действия в связи с этим со стороны обоих родителей, систем семьи, здравоохранения, образования и государства.
The article explicates the essence of the existential meaning of the perinatal period at all its phases in human life. The objective necessity of an adequate reaction and action in this regard on the part of both parents, family systems, health care, education and the state is proved.