bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repeat Revascularization After Contemporary Percutaneous Coronary Intervention
Authors: Stolker Joshua M. , Cohen David J. , Kennedy Kevin F. , Pencina Michael J. , Lindsey Jason B. , Mauri Laura , Cutlip Donald E. , Kleiman Neal S. 
Published: October 2012

Background—
Although drug-eluting stents and intensive secondary prevention have contributed to improved outcomes after percutaneous coronary intervention (PCI), repeat revascularization remains relatively common in contemporary practice. We used data from the multicenter Evaluation of Drug-Eluting Stents and Ischemic Events registry to evaluate the relative frequency and timing of staged revascularization, target lesion revascularization (TLR), and other nontarget revascularization during the first year after contemporary PCI.

Methods and Results—
Patients with staged revascularization, TLR, and other unplanned procedures (elsewhere in the target vessel or in other coronary arteries) were evaluated in time-dependent models using Kaplan-Meier life-table estimation. Predictors of TLR and unplanned revascularization at nontarget sites were identified using logistic regression. Between July 2004 to June 2007, 10 144 patients undergoing PCI were enrolled at 55 US hospitals, of whom 86% were treated with at least 1 drug-eluting stent. Twelve percent required repeat revascularization within the first year (3% staged; 9% unplanned). More than 75% of staged revascularizations were performed <30 days after index PCI, although there was significant variation in this practice across hospitals (range, 0%–54%). TLR occurred in 4.5% of patients, with higher hazard rates between 2 to 9 months after PCI, whereas the risk of unplanned non-TLR (4.4% cumulative incidence) was constant over time.

Conclusions—
Among unselected patients undergoing PCI in the drug-eluting stent era, the incidence of repeat revascularization at 1 year is ≈12%. Among unplanned procedures, only half are performed for TLR. To achieve further improvements in PCI outcomes, future efforts should concentrate as much on identifying ischemia-producing lesions and intensifying secondary prevention therapies as on the prevention of restenosis.
A Nutrient-Wide Association Study on Blood Pressure
Authors: Tzoulaki Ioanna , Patel Chirag J. , Okamura Tomonori , Chan Queenie , Brown Ian J. , Miura Katsuyuki , Ueshima Hirotsugu , Zhao Liancheng , Van Horn Linda , Daviglus Martha L. , Stamler Jeremiah , Butte Atul J. , Ioannidis John P.A. , Elliott Paul 
Published: October 2012

Background—
A nutrient-wide approach may be useful to comprehensively test and validate associations between nutrients (derived from foods and supplements) and blood pressure (BP) in an unbiased manner.

Methods and Results—

Data from 4680 participants aged 40 to 59 years in the cross-sectional International Study of Macro/Micronutrients and Blood Pressure (INTERMAP) were stratified randomly into training and testing sets. US National Health and Nutrition Examination Survey (NHANES) four cross-sectional cohorts (1999–2000, 2001–2002, 2003–2004, 2005–2006) were used for external validation. We performed multiple linear regression analyses associating each of 82 nutrients and 3 urine electrolytes with systolic and diastolic BP in the INTERMAP training set. Significant findings were validated in the INTERMAP testing set and further in the NHANES cohorts (false discovery rate <5% in training,
P
<0.05 for internal and external validation). Among the validated nutrients, alcohol and urinary sodium-to-potassium ratio were directly associated with systolic BP, and dietary phosphorus, magnesium, iron, thiamin, folacin, and riboflavin were inversely associated with systolic BP. In addition, dietary folacin and riboflavin were inversely associated with diastolic BP. The absolute effect sizes in the validation data (NHANES) ranged from 0.97 mm Hg lower systolic BP (phosphorus) to 0.39 mm Hg lower systolic BP (thiamin) per 1-SD difference in nutrient variable. Inclusion of nutrient intake from supplements in addition to foods gave similar results for some nutrients, though it attenuated the associations of folacin, thiamin, and riboflavin intake with BP.

Conclusions—
We identified significant inverse associations between B vitamins and BP, relationships hitherto poorly investigated. Our analyses represent a systematic unbiased approach to the evaluation and validation of nutrient-BP associations.
Reperfusion Therapy in Unclear-Onset Stroke Based on MRI Evaluation (RESTORE)
Authors: Kang Dong-Wha , Sohn Sung-Il , Hong Keun-Sik , Yu Kyung-Ho , Hwang Yang-Ha , Han Moon-Ku , Lee Jun , Park Jong-Moo , Cho A-Hyun , Kim Hye-Jin , Kim Dong-Eog , Cho Yong-Jin , Koo Jaseong , Yun Sung-Cheol , Kwon Sun U. , Bae Hee-Joon , Kim Jong S. 
Published: October 2012

Background and Purpose—
Unclear-onset strokes are generally excluded from time-based thrombolytic therapy. We examined the safety and feasibility of magnetic resonance imaging-based reperfusion therapy in unclear-onset stroke.

Methods—
This prospective, multicenter, single-arm study screened consecutive unclear-onset stroke patients within 6 hours of symptom detection. Patients with perfusion-diffusion mismatch >20% and negative or subtle fluid-attenuated inversion recovery changes were treated with intravenous tissue plasminogen activator, intra-arterial therapy, or a combination. The safety outcome was symptomatic intracranial hemorrhage within 48 hours after treatment. The primary efficacy outcome was a 3-month modified Rankin Scale score of 0 to 2. Controls were untreated unclear-onset stroke patients prospectively captured in stroke registries.

Results—
Of 430 unclear-onset stroke patients, 83 (19.3%) received reperfusion therapy (mean age, 67.5 ± 10.4 years; males, 66.3%; median baseline National Institutes of Health Stroke Scale, 14). Symptomatic intracranial hemorrhage with any neurological decline developed in 5 patients (6.0%). Symptomatic intracranial hemorrhage with National Institutes of Health Stroke Scale worsening ≥4 developed in 3 patients (3.6%). Thirty-seven patients (44.6%) achieved modified Rankin Scale score of 0 to 2, and 24 (28.9%) had modified Rankin Scale score of 0 to 1. Female, baseline National Institutes of Health Stroke Scale score, no immediate or early recanalization, and more white blood cells were independent predictors of poor outcome. Compared with untreated controls, the treated group was significantly associated with good outcomes of modified Rankin Scale score of 0 to 2 after adjusting for age, sex, and baseline National Institutes of Health Stroke Scale in logistic regression analysis (odds ratio, 2.25; 95% CI, 1.14–4.49).

Conclusions—
In unclear-onset stroke patients, magnetic resonance imaging-based reperfusion therapy was feasible and safe. Randomized controlled trials are warranted to confirm the benefit of reperfusion therapy for unclear-onset stroke.
Improvement of TMI Rain Retrievals in Mountainous Areas
Authors: Shige Shoichi , Kida Satoshi , Ashiwake Hiroki , Kubota Takuji , Aonashi Kazumasa 
Published: October 2012

AbstractHeavy rainfall associated with shallow orographic rainfall systems has been underestimated by passive microwave radiometer algorithms owing to weak ice scattering signatures. The authors improve the performance of estimates made using a passive microwave radiometer algorithm, the Global Satellite Mapping of Precipitation (GSMaP) algorithm, from data obtained by the Tropical Rainfall Measuring Mission (TRMM) Microwave Imager (TMI) for orographic heavy rainfall. An orographic/nonorographic rainfall classification scheme is developed on the basis of orographically forced upward vertical motion and the convergence of surface moisture flux estimated from ancillary data. Lookup tables derived from orographic precipitation profiles are used to estimate rainfall for an orographic rainfall pixel, whereas those derived from original precipitation profiles are used to estimate rainfall for a nonorographic rainfall pixel. Rainfall estimates made using the revised GSMaP algorithm are in better agreement with estimates from data obtained by the radar on the TRMM satellite and by gauge-calibrated ground radars than are estimates made using the original GSMaP algorithm.
Global Warming Shifts the Monsoon Circulation, Drying South Asia
Authors: Annamalai H. , Hafner Jan , Sooraj K. P. , Pillai P. 
Published: October 2012

Abstract
Monsoon rainfall over South Asia has decreased during the last 5 to 6 decades according to several sets of observations. Although sea surface temperature (SST) has risen across the Indo-Pacific warm pool during this period, the expected accompanying increased rainfall has occurred only in the tropical western Pacific.
The above changes noted in observations are also seen in a coupled climate model, but only when the model includes the recent increase in greenhouse gas concentration. The hypothesis that the robust rise in SST over the warm pool, perhaps anchored by an increase in greenhouse gas concentrations, is instrumental in the east–west shift in monsoon rainfall (enhanced rainfall over tropical western Pacific and decreased rainfall over South Asia) is proposed. A suite of controlled experiments with an atmospheric general circulation model has been performed to isolate the impact of regional SST warming trends on the dryness over South Asia. Model experiments support the hypothesis that the rising SST trend over the tropical western Pacific has changed the atmospheric circulation: over the Bay of Bengal more dry and cool air is advected from the northeast than previously. Moist static energy budget diagnostics on the model solutions identify the sources for this east–west shift.
SST warming over the warm pool has accelerated in recent decades. Therefore, a close monitoring of that warming is important for long-term variations of monsoon rainfall. The inconsistency in the amplitude of drying over South Asia among the various land-based rainfall observations and lack of sustained rainfall observations over the open oceans, however, poses constraints in the results.
Removing Spurious Low-Frequency Variability in Drifter Velocities
Authors: Lumpkin Rick , Grodsky Semyon A. , Centurioni Luca , Rio Marie-Helene , Carton James A. , Lee Dongkyu 
Published: October 2012

Abstract
Satellite-tracked drifting buoys of the Global Drifter Program have drogues, centered at 15-m depth, to minimize direct wind forcing and Stokes drift. Drogue presence has historically been determined from submergence or tether strain records. However, recent studies have revealed that a significant fraction of drifters believed to be drogued have actually lost their drogues, a problem that peaked in the mid-2000s before the majority of drifters in the global array switched from submergence to tether strain sensors. In this study, a methodology is applied to the data to automatically reanalyze drogue presence based on anomalous downwind ageostrophic motion. Results indicate that the downwind slip of undrogued drifters is approximately 50% higher than previously believed. The reanalyzed results no longer exhibit the dramatic and spurious interannual variations seen in the original data. These results, along with information from submergence/tether strain and transmission frequency variations, are now being used to conduct a systematic manual reevaluation of drogue presence for each drifter in the post-1992 dataset.
The nocebo effect: A clinicians guide
Authors: Data-Franco João , Berk Michael 
Published: October 2012

Objective: This paper aims to provide an overview on the nocebo effect, focusing on recognition — its phenomenology, at-risk demographic profiles, clinical situations and personality factors, as well as discriminating somatic symptoms in the general population from treatment-related adverse effects. Lastly, the paper addresses available evidence-based strategies for management and minimisation of the nocebo effect. Method: Data for this paper were identified by searching PubMed using the search terms "nocebo" and “nocebo effect”, augmented by a manual search of the references of the key papers and the related literature. Results: The nocebo effect refers to non-pharmacodynamic, harmful or undesirable effects occurring after inactive treatment, a phenomenon that also occurs in the context of active therapy. Known drivers include classical conditioning and negative expectations concerning treatment. Recent meta-analyses have reported a considerable prevalence, ranging from 18% in the symptomatic treatment of migraine, to more than 74% in multiple sclerosis. Recognition of the nocebo-driven adverse effects presents a challenge, especially because of its non-specific nature and the similarity to the active medication’s expected profile. Traits such as neuroticism, pessimism and type A personalities may predispose individuals to this phenomenon. Clinical management of the nocebo effect includes awareness and recognition, changing the manner of disclosure of potential drug-related adverse effects, shaping patients’ expectations and enhancing the treatment alliance. Conclusion: The nocebo effect is a common, clinically significant, yet covert driver of clinical outcomes. Increased awareness of its features, as well as knowledge of strategies on how to manage it, are fundamental so that clinicians can mitigate its impact on clinical practice.
Therapeutic effects of vitamin D as adjunctive therapy to fluoxetine in patients with major depressive disorder
Authors: Khoraminya Nayereh , Tehrani-Doost Mehdi , Jazayeri Shima , Hosseini Aghafateme , Djazayery Abolghassem 
Published: October 2012

Objective: To compare the therapeutic effects of vitamin D3 plus fluoxetine and fluoxetine alone in patients with major depressive disorder. Methods: In the present double-blind, randomized, placebo-controlled trial, 42 patients with a diagnosis of major depressive disorder based on DSM-IV criteria were randomly assigned into two groups to receive daily either 1500 IU vitamin D3 plus 20 mg fluoxetine or fluoxetine alone for 8 weeks. Depression severity was assessed at 2-week intervals using the 24-item Hamilton Depression Rating Scale (HDRS) as a primary outcome measure and the 21-item Beck Depression Inventory (BDI) as a secondary outcome measure. Serum 25(OH) vitamin D was measured at baseline and after intervention. Results: Forty patients completed the trial. A two-way repeated-measures analysis of variance showed that depression severity based on HDRS and BDI decreased significantly after intervention, with a significant difference between the two groups. The vitamin D + fluoxetine combination was significantly better than fluoxetine alone from the fourth week of treatment. Conclusions: In the present 8-week trial, the vitamin D + fluoxetine combination was superior to fluoxetine alone in controlling depressive symptoms.
Does a nutrition education programme change the knowledge and practice of healthy diets among high school adolescents in Chennai, India?
Authors: Rani M Anitha , Shriraam Vanishree , Zachariah Rony , Harries Anthony D , Satyanarayana Srinath , Tetali Shailaja , Anchala Raghupathy , Muthukumar Diviya , Sathiyasekaran BWC 
Published: October 2012

Background: Nutrition education is used as a way of promoting lifelong healthy eating practices among school adolescents. There is limited published information on the impact of nutrition education programmes in India. Objectives: To assess the knowledge and practices of high school students with respect to healthy diets before and after a nutrition education programme. Design: Pre- and post-intervention questionnaire survey. Setting: Two private schools in Chennai city. Method: This study was conducted among adolescents studying in standard VIII and IX in two private schools in Chennai city. Nutrition education as lectures and interactive discussions were given to students one hour every week for a period of 10 weeks. Information on knowledge and attitude on healthy eating and dietary practices was collected before and after the nutrition education intervention using a questionnaire. Differences in knowledge, attitude and practice of students on healthy diet were measured using the X2 test with the level of significance p<0.05. Results: A total of 181 students were involved in the study (response rate 92%). Following the nutrition education programme, satisfactory dietary knowledge significantly improved from 37% to 67% ( p<0.001). Similarly, students showing a positive attitude towards healthy diet increased from 18% to 40% ( p<0.001). The proportion of students taking soft drinks reduced from 20% to 10% ( p<0.01) and ingestion of fast food items through fast food restaurants reduced significantly. Conclusions: This short-term nutrition education programme brought significant improvements in dietary knowledge and reductions in soft drinks and fast foods consumption.
Can a brief educational intervention improve parents’ knowledge of healthy children’s sleep? A pilot-test
Authors: Jones Caroline HD , Owens Judith A , Pham Brian 
Published: October 2012

Objective: Insufficient and poor quality sleep is prevalent in children, and is a significant public health concern due to the negative consequences for health. Certain sleep-related behaviours are associated with improved sleep, and sleep behaviours are amenable to efforts targeted towards behaviour change. Parental educational interventions have been successful at improving parents’ knowledge and children’s health outcomes in some areas of health, but no population-based educational interventions have been designed to improve parents’ knowledge of healthy children’s sleep. This study aimed to design and test an educational tool to increase caregivers’ knowledge of healthy children’s sleep in a primary care setting. Setting: A hospital-based pediatric primary care clinic where children attend for well-child and sick visits. Method: Parents of 95 children aged three months to 12 years completed two surveys, one prior to and one after receiving the intervention. The surveys assessed children’s sleep habits (pre-intervention) and parental sleep beliefs and sleep knowledge (pre- and post-intervention). The intervention was a short, informational brochure. Results: Following the intervention there was a significant increase in parents’ knowledge regarding children’s healthy sleep, and in the number of parents who planned to make positive behaviour changes regarding their child’s sleep practices. Conclusion: Simple written educational interventions may be effective tools with which to increase parents’ knowledge and promote healthy sleep behaviours in children.
Barriers to the diagnosis and treatment of venous thromboembolism in advanced cancer patients: A qualitative study
Authors: Sheard Laura , Prout Hayley , Dowding Dawn , Noble Simon , Watt Ian , Maraveyas Anthony , Johnson Miriam 
Published: October 2012

Background: Venous thromboembolism is common in patients with cancer and the risk increases with advanced disease. Evidence-based treatment is administration of low-molecular-weight heparin daily by subcutaneous injection. Clinical uncertainty exists as to whether treating venous thromboembolism in advanced disease is in the patient’s best interests. Aim: To explore the barriers faced by doctors when diagnosing and treating patients with cancer-associated thrombosis. Design: Qualitative, in-depth interview study using framework analysis. Participants: Forty-five UK doctors across urban and rural settings, from three specialties, oncology, palliative medicine and general practice, with a mixture of senior and junior staff. Results: Organisational constraints served to act as barriers to the diagnosis and treatment of this patient group. Issues were identified around access to diagnostic testing. A cancer-associated thrombosis patient having to wait for a scan as an inpatient was sometimes deemed unnecessary. Patient ambulance transport (especially transportation of hospice patients) was often viewed as inflexible and bureaucratic. Low-molecular-weight heparin prescribing had sometimes led to tension between the acute, community and hospice sectors about whose prescribing responsibility this was, with different areas having divergent ‘rules’ and practices. Finally, the doctors interviewed discussed the role of nurses. Conclusions: Multiple logistical barriers are hindering best patient care for people with cancer-associated thrombosis. There is scope for some of these barriers to be reduced to improve service delivery and ultimately patient care. The research team proposes practical recommendations, which could yield direct benefit for patients and the health services.
Hyperthyroidism in Cats
Authors: Peterson Mark 
Published: October 2012

Practical relevance: Since first being reported in the late 1970s, there has been a dramatic increase in the prevalence of hyperthyroidism in cats. It is now recognized worldwide as the most common feline endocrine disorder. Patient group: Hyperthyroidism is an important cause of morbidity in cats older than 10 years of age. It is estimated that over 10% of all senior cats will develop the disorder. Clinical challenges: Despite its frequency, the underlying cause(s) of this common disease is/are not known, and no one has suggested a means to prevent the disorder. Because of the multiple risk factors that have been described for feline hyperthyroidism, it is likely that more than one factor is involved in its pathogenesis. Continuous, lifelong exposure to environmental thyroid disruptor chemicals or goitrogens in food or water, acting together in an additive or synergistic manner, may first lead to euthyroid goiter and then to autonomous adenomatous hyperplasia, thyroid adenoma and hyperthyroidism. Evidence base: This review draws on published research studies to summarize the available evidence about the risk factors for feline hyperthyroidism. Based on the known goitrogens that may be present in the cat’s food, drinking water or environment, it proposes measures that cat owners can implement that might prevent, or reduce the prevalence of, thyroid tumors and hyperthyroidism in their cats.