bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pleural effusion, ascites, colon ulcers and hematochezia: What we can learn from the diagnostic process of a patient with plasma cell myeloma: A case report
Authors: Yan Ming-Xian 
Published: June 2024

BACKGROUND
Plasma cell myeloma (PCM) is characterized by hypercalcemia, renal impairment, anemia, and bone destruction. While pleural effusion, ascites, abdominal pain, and bloody stool are common manifestations of lung disease or gastrointestinal disorders, they are rarely observed in patients with PCM.
CASE SUMMARY
A 66-year-old woman presented with complaints of recurrent chest tightness, wheezing, and abdominal bloating accompanied by bloody stools. Computed tomography revealed pleural effusion and ascites. Pleural effusion tests showed inflammation, but the T-cell spot test and carcinoembryonic antigen were negative. Endoscopy showed colonic mucosal edema with ulcer formation and local intestinal lumen stenosis. Echocardiography revealed enlarged atria and reduced left ventricular systolic function. The diagnosis remained unclear. Further testing revealed elevated blood light chain lambda and urine immunoglobulin levels. Blood immunofixation electrophoresis was positive for immunoglobulin G lambda type. Smear cytology of the bone marrow showed a high proportion of plasma cells, accounting for about 4.5%. Histopathological examination of the bone marrow suggested PCM. Flow cytometry showed abnormal plasma cells with strong expression of CD38, CD138, cLambda, CD28, CD200, and CD117. Fluorescence in situ hybridization gene testing of the bone marrow suggested 1q21 gene amplification, but cytogenetic testing showed no clonal abnormalities. Colonic mucosa and bone marrow biopsy tissues were negative for Highman Congo red staining. The patient was finally diagnosed with PCM.
CONCLUSION
A diagnosis of PCM should be considered in older patients with pleural effusion, ascites, and multi-organ injury.
Goblet cell carcinoid of the appendix: Six case reports
Authors: Toshima Toshiaki , Inada Ryo , Sakamoto Shinya , Takeda Eri , Yoshioka Takahiro , Kumon Kento , Mimura Naoki , Takata Nobuo , Tabuchi Motoyasu , Oishi Kazuyuki , Sato Takuji , Sui Kenta , Okabayashi Takehiro , Ozaki Kazuhide , Nakamura Toshio , Shibuya Yuichi , Matsumoto Manabu , Iwata Jun 
Published: June 2024

BACKGROUND
Goblet cell carcinoid (GCC) of the appendix is a rare tumor characterized by neuroendocrine and adenocarcinoma features. Accurate preoperative diagnosis is very difficult, with most patients complaining mainly of abdominal pain. Computed tomography shows swelling of the appendix, so diagnosis is usually made incidentally after appendectomy based on a preoperative diagnosis of appendicitis. Even if a patient undergoes preoperative colonoscopy, accurate endoscopic diagnosis is very difficult because GCC shows a submucosal growth pattern with invasion of the appendiceal wall.
CASE SUMMARY
Between 2017 and 2022, 6 patients with GCC were treated in our hospital. The presenting complaint for 5 of these 6 patients was abdominal pain. All 5 patients underwent appendectomy, including 4 for a preoperative diagnosis of appendicitis and the other for diagnosis and treatment of an appendiceal tumor. The sixth patient presented with vomiting and underwent ileocecal resection for GCC diagnosed from preoperative biopsy. Although 2 patients with GCC underwent colonoscopy, no neoplastic changes were identified. Two of the six patients showed lymph node metastasis on pathological examination. As of the last follow-up (median: 15 mo), all cases remained alive without recurrence.
CONCLUSION
As preoperative diagnosis of GCC is difficult, this possibility must be considered during surgical treatments for presumptive appendicitis.
Neonatal tachypnea caused by diaphragmatic paralysis: A case report
Authors: Zeng Yan , Luo Pei , Zhao Di-Ran , Wang Feng-Yang , Song Bin 
Published: June 2024

BACKGROUND
Diaphragmatic paralysis is typically associated with phrenic nerve injury. Neonatal diaphragmatic paralysis diagnosis is easily missed because its manifestations are variable and usually nonspecific.
CASE SUMMARY
We report a 39-week-old newborn delivered via vaginal forceps who presented with tachypnea but without showing other birth-trauma-related manifestations. The infant was initially diagnosed with pneumonia. However, the newborn still exhibited tachypnea despite effective antibiotic treatment. Chest radiography revealed right diaphragmatic elevation. M-mode ultrasonography revealed decreased movement of the right diaphragm. The infant was subsequently diagnosed with diaphragmatic paralysis. After 4 weeks, tachypnea improved. Upon re-examination using M-mode ultrasonography, the difference in bilateral diaphragmatic muscle movement was smaller than before.
CONCLUSION
Appropriate use of M-mode ultrasound to quantify diaphragmatic excursions could facilitate timely diagnosis and provide objective evaluation.
Isolation and Characterisation of Essential oils of Mango (M. indica) Leave
Authors: Abubakar Auwal , Shagal Mohammed Hassan , Milan Charles 
Published: July 2024

This research work aimed at isolation and characterisation of essential oils of Mangifera. indica (M. indica) leaves. Phytochemical screening was carried out to determine the bioactive components present in the leaf sample as well as the antimicrobial activity of the crude ethanolic extract. The percentage yield of essential oils (colourless) of the leaf was 0.19%. The phytochemical screening revealed the presence of alkaloid, glycoside, flavonoid, saponin and tannin. Steroids was absent in the extract. The antimicrobial evaluation of the essential oil of M. indica leaf revealed a significant activity (zone of inhibition). The percentage (%) of Diphenyl picryl hydrazine (DPPH) scavenged of antioxidant activities for the essential oils of M. indica at different concentration of 5µl, 10µl, 25µl and 100 µl showed a significant antioxidant activity. In concluded results, it’s clearly observed that, when the concentration of both ethanolic extract and essential oils leaf sample increases, the antimicrobial and antioxidant properties increases when compared to the standard (Amoxicillin) and that of essential oils has a significant property than other extracts. Considering the results of phytochemical screening, it’s also a potential source of cost-effective food supplements, nutritive ingredients and antibacterial agent for improving human health and curing acute and chronic diseases. The GC-MS analysis of the essential oils for the leaf sample revealed fifty two (52) different chemical compounds which include Alloaromadendrene, Humulene, Bicyclo[4,4,0]dec-1-ene, 2-isopropyl-5-methyl-9-methylene, Bicyclo[7.2.0]undec-4-ene,4,11,11,-trimethyl 8-methylene-,[1R-(1R*,4Z,9S*)].
One Journal, Different Practices: A Corpus-Based Study of Interactive Metadiscourse in Applied Linguistics
Authors: Lu Sitong , Jiang Feng (Kevin) 
Published: July 2024

Abstract
Research articles are a primary medium for scholars to communicate with disciplinary community, but there is little evidence suggesting how much writing practices on different research subjects within a discipline diverge in a single journal. This study remedies the oversight by comparing the use of interactive metadiscourse in the papers of Applied Linguistics on language acquisition and discourse analysis. Based on a corpus of 30 research articles on each research subject, results show that writers in language acquisition make a significantly more frequent use of additive and consequential transitional markers, reformulators, and non-integral citations. However, discourse analysts prefer to invest in exemplifiers, linear and non-linear references and topic shifts. All the differences can be attributable to the characteristics of disciplinary research paradigms, which lead to different knowledge-making and interactive patterns in academic writing. The findings offer empirical evidence to the rhetorical function of metadiscourse in constructing disciplinary knowledge, and raise pedagogical implications for EAP instructors to help scholars in applied linguistics increase international publications.
Microwave-supported one-pot reaction for the synthesis of 5-alkyl/arylidene-2-(morpholin/thiomorpholin-4-yl)-1,3-thiazol-4(5H)-one derivatives over MgO solid base
Authors: Nguyen Thi Son , Nguyen Van Duc , Thuy Linh Nguyen Nhat , Nam Anh Pham , Luu Van Boi , Do Huy Hoang 
Published: July 2024

Abstract
In this study, we synthesized 5-alkyl/arylidene-2-(morpholin/thiomorpholin-4-yl)-1,3-thiazol-4(5H)-one through a one-pot reaction using all starting materials in a microwave oven. The presence of the solid base MgO catalyzed the reaction in the eco-friendly solvent of ethanol as a green chemistry approach owing to the noticeable advantages of short reaction times to save energy and less toxic starting materials for environmental friendliness. This indicates that the one-pot reaction makes the process simpler, in which the reaction time (1 h) is shorter than that of conventional methods (10 h). The yield of the reactions reached 55–76% for 18 final products consisting of 17 derivatives of morpholine or thiomorpholine with various aldehydes and one extended moiety of the primary amine, of which 13/18 final compounds were new. The purification procedure was performed without using polluting solvents. The structures were confirmed using IR, 1H-NMR, 13C-NMR, and MS analyses.
The impact of digitalization on corporate strategy in the heat-power industry
Authors: Popov G. S. 
Published: June 2024

The article analyzes 8 directions areas of digitalization that affect corporate strategizing in the heat-power industry, classifies this direction into demanded and prospective, and conducts an OTSW analysis of these directions and their features that have a significant impact on the development of the industry. The main objectives of the study were to study the strategic trend of digitalization in the context of the heat-power industry, analyze the application and relevance of the main aspects of digitalization in strategic public documents of heat generating companies in Russia such as PJSC “Gazprom Energoholding”, PJSC “T-Plus”, PJSC “Quadra”, and identify prospects and the problems they face in the context of the current level of digitalization. The main methodological school on which the research is based is the scientific school of strategy by V.L. Kvint.The article emphasizes the important role of digitalization as one of the leading drivers of development of the heat-power industry and demonstrates examples of digitalization of operational processes of the heat generating companies. The OTSW analysis reveals negative characteristics of the digitalization trend, mainly associated with economic costs that limit its active implementation in the industry. The conducted research leads to the conclusion that digitalization is not only a trend, but also a global investment project for the heat generating companies and for the industry as a whole, stimulating investments increase in complex technological virtual and material systems and devices.
Formation of a system of production capacity indicators
Authors: Kuznetsov D. V. , Feingold M. L. 
Published: June 2024

The term “production capacity” has always been one of the most important in the theory and practice of production management of an engineering enterprise. In the current conditions the issues of determining and classifying production capacity of manufacturing enterprises are of particular significance. Possessing reliable data on production capacity of a manufacturing enterprise one can determine the production output and the equipment workload level, and run the available production facilities effectively. The reliability of the information essential for decision-making depends on the methodology of determining and classifying production capacity of manufacturing enterprises. The purpose of the study is to reveal the contents of the system of specific indicators of the term “production capacity”. To achieve the goal the author of the article studies the problems of evaluation of production capacity of separate manufacturing structural units and the entire company. The subject of the study is the principles and methods of classification of the indicators of production capacity of a manufacturing enterprise. The article presents the author’s approach to defining the essence and classifying the production capacity indicators. To achieve the goal the authors applied the analysis and synthesis methods. Application of the deduction principle allowed creating a system of production capacity indicators. The study has been based on the review of relevant scientific and periodical economic publications. The contents and the volume of the “production capacity” concept have been established. The proposed system of individual indicators of production capacity allows increasing the accuracy of calculation of production capacity, identify time reserves for various operations, efficiently plan the equipment exploitation and improve operational and calendar planning at the manufacturing enterprise.
Strategic aspects of increasing efficiency of economic activity of industrial enterprises
Authors: Shatskaya I. V. , Danilina E. I. 
Published: June 2024

The article is devoted to the topical issues of the domestic industry. The authors consider the category of “the efficiency of economic activity” as a target landmark in the activity of an industrial enterprise. This landmark is a combination of parameters characterizing the accumulated effect level caused by the company’s improvement of the organization of operational process. The authors study the efficiency not as a leading objective of the company’s activity but as a result of its development strategy and within the framework of the strategy. Digitalization of a company’s business process is a tool which ensures creating conditions for improving the efficiency of an industrial company’s economic activity. The article determines the significance of digitalization in the industry for improving the efficiency of the company’s activity. And major attention is focused on the peculiar features of digitalization in the sphere of industry. The authors give grounds for its role in the activity of enterprises, pointing out that digitalization contributes to improving the mechanism of its regulation as well as provides for the company’s economic effect.The purpose of the article is to study digitalization in the context of its impact on the efficiency of the economic activity of an industrial enterprise, and to consider the opportunities and challenges of digitalization of the industrial production sphere. In accordance with the purpose the authors have set the tasks connected with studying scientific categories of “the efficiency of economic activity: and “strategic development”, examining strategic issues of improving the efficiency of the activity of industrial enterprise, overviewing the peculiar features of digitalization of industrial production which determine the priorities for future development of the domestic economics.The theoretical and methodological basis of the study includes scientific achievements of the scientific school of strategizing under the Lomonosov Moscow State University as well as scientific achievements of domestic and foreign researchers regarding the issues of improving the efficiency of economic activity of enterprises. To justify the results the authors use the combination of research methods and approaches of analysis and synthesis, comparison, generalization, scientific abstraction.
The type-section of the Gutenstein Formation at Gutenstein revisited (Anisian, Northern Calcareous Alps, Lower Austria): Lithostratigraphy, biostratigraphy and regional overview
Authors: Moser Michael , Wagreich Michael , Piros Olga 
Published: June 2024

Abstract
New biostratigraphic data derived from the stratotype of the Gutenstein Formation at the village Gutenstein (Lower Austria) help to solve some long-standing problems about the stratigraphy of the Anisian stage within the eastern part of the Northern Calcareous Alps. At Gutenstein, the lower lithostratigraphic boundary of the Anisian Gutenstein Formation to the underlying lower Anisian Reichenhall Formation is defined, assuming a normal stratigraphic contact of the Reichenhall Formation to the underlying Werfen Formation and to the overlying Gutenstein Formation. Microfacial data confirm the sedimentary origin of the rauwackes of the Reichenhall Formation. A detailed lithostratigraphic and facies-oriented definition of the Gutenstein Formation includes prevailing thin and planar-bedded, black colored, sometimes fine-bedded limestone (rarely dolostone) and radiolarian (calcispheres) bearing, black colored mud- to wackestone, mostly containing some fine crinoid debris. Upsection, a quick change to an upper (Pelsonian) member of the Gutenstein Formation with nodular bedding planes and brachiopod-, crinoid-, conodont- and ammonite accumulations is presented. The general depositional environment of the Gutenstein Formation is interpreted as a dysoxic outer carbonate ramp deposit, with a shallowing upward trend to rather thick-bedded mid- and inner carbonate ramp settings of the Annaberg- and Steinalm formations. The approximate interval of the Anisian/Ladinian boundary within the type-section of Gutenstein is determined with help of new fossil findings such as dasycladalean green-algae. Based on distinct lithological differences on a regional scale, which occur in thick basinal stratigraphic successions within the Gutenstein Formation like at Großreifling (Styria, Bajuvaric Nappe System), at Innerfahrafeld (elevation Fuchsriegel, Lower Austria) and on mount Kasberg at Grünau (Upper Austria, Tirolic Nappe System), a subdivision of the Gutenstein Formation into a lower Gutenstein Member, and an upper Kasberg Member (= Upper Gutenstein Formation), is proposed herein. The lower member corresponds to the black, thin- and planar-bedded interval, whereas the Kasberg Member is characterized by nodular bedding planes, greater bed thicknesses and higher fossil content.
Maps of Quaternary sediments and features in Austria and neighbouring countries at the scales of 1:500 000 and 1:1 500 000
Authors: Griesmeier Gerit E.U. 
Published: June 2024

Abstract
Today’s landscape and morphology of Austria is markedly affected by erosional and sedimentary processes active during the Quaternary. Particularly, large glaciers have shaped the landscape of the Eastern Alps. The presented maps at the scales of 1:500 000 and 1:1 500 000 aim to visualise areas, where deposition or erosion in different stages of the Quaternary prevailed. The maps (free download available) were generated with ArcGIS software using available map sheets at larger scales (1:50 000, 1:200 000). No additional field work has been conducted. The most obvious observation is that an extensive cover of Quaternary sediments predominantly occurs in the northern Alpine foreland, especially outside of Austria.
The maps show that large glacier tongues of the Middle to Late Pleistocene glaciations (Günz, Mindel, Riss and Würm) existed in the northern and southeastern alpine foreland. In the east, hardly any signs of glacial coverage are visible due to later fluvial cannibalisation of features partly deposited in narrow valleys. Bordering terminal moraines, extensive, terraced fluvial deposits occur within and around the Alps showing that river courses partly changed during the Pleistocene. Aeolian sediments often accompany these sediments, but also cover huge areas in the Vienna and Tulln Basin and the Little Hungarian plain. The distribution of large rockslide events shows that they mainly formed in glacially covered areas as a result of rock destabilisation after glacier retreat. Additionally, the map shows that the alpine foreland is subject of inhomogeneous uplift since the Neogene. For example, between Salzburg and Munich, wide areas are covered by Pleistocene deposits, whereas to the west of Munich and in Upper Austria, recent rivers incised deeper into Neogene sediments.
Prevalence of extended spectrum beta-lactamase and metallo-beta-lactamase genes in imipenem resistant Pseudomonas aeruginosa from admitted patients in a tertiary level hospital, Bangladesh
Authors: Kabir Rubaiya Binte , Jobayer Mohammad , Farhana Nasreen , Shamsuzaman S. M. 
Published: June 2024

Background: Pseudomonas aeruginosa are known for their multiple mutations and rapid acquirement of antimicrobial resistance genes. The presence of metallo-β-lactamase (MBL) is the commonest reason for the treatment failure in carbapenem therapy. Production of extended spectrum β-lactamase (ESBL) in these isolates makes the treatment more challenging. Due to the importance of the carbapenems in resistant infection management, finding the true frequencies of such enzymes is imperative.
Methods: A total of 446 samples were collected from the admitted patients with infected burn, surgical wound, and endotracheal tube in situ. Isolation and identification of organisms and antimicrobial susceptibility testing were done by established methods. Identification of P. aeruginosa was confirmed by polymerase chain reaction (PCR). Production of ESBLs was detected phenotypically by double disc synergy, and MBL by double-disc synergy, combined disc, and modified Hodge test. Genes encoding ESBLs and MBLs were detected by PCR.
Results: Among the 446 samples, 84.31% yielded growth, from which 232 (61.70%) were P. aeruginosa. Among the P. aeruginosa, 72 (31.03%) were resistant to imipenem. Phenotypically, 57 (79.17%) of these strains were ESBL and all were MBL producers. blaOXA-10 was the most common ESBL encoding gene (29.83%). blaNDM-1 was the most prevalent MBL encoding gene (34.72%). Moreover, 27 (38%) imipenem resistant P. aeruginosa had concurring ESBL and MBL genes.
Conclusions: The substantial percentages of ESBL, MBL and simultaneous presence of both genes suggests routine screening of these genes which will provide an opportunity for better selection of antimicrobials in the management of resistant P. aeruginosa.
Cost effective analysis of open and laparoscopic inguinal mesh hernioplasty
Authors: Jain Akshay , Kumar Ameet , Patel Neelesh , Patrikar Seema 
Published: June 2024

Background: Inguinal Hernia mesh repair surgery is one of the most commonly conducted surgical procedures. Between two approaches: open and laparoscopic, which is better for the patient in terms of cost and outcome in terms of quality of life and return to economic activity. To facilitate comparability across studies, cost effectiveness analysis requires measurement of both costs and quality adjusted life years (QALY).
Methods: Descriptive, observational study which entails classifying costs, identifying cost centres, tracing all costs related to the elective procedures for inguinal mesh hernioplasty by both open and laparoscopic methods followed by checking the Quality of life pre and post-surgery of these patients through the EQ-5D-3L by telephonic interview. A Cost Effective analysis was conducted by the end of the study. Based on available data, we took 35 cases of laparoscopic procedure and 45 cases of open surgery as a universal sample size.
Results: Traditional costing showed a difference of approximately INR 3245.93/- in the 2 procedures with laparoscopic surgery being costlier. Significant improvements were noted in patients post laparoscopic surgeries with less people complaining of post operative pain/discomfort and early resumption of daily activities and mobility within a month after the surgery. ICER is tilted in favour of laparoscopic surgeries by a value of Rs 1,08,197.66 per QALY.
Conclusions: The difference in cost is minimal but the difference in the QALY scores and ultimately the ICER determines that laparoscopic surgery has an edge over open surgery in terms of outcome and patient comfort.