bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk factors for binge eating and purging eating disorders: Differences based on age of onset
Authors: Allen Karina L. , Byrne Susan M. , Oddy Wendy H. , Schmidt Ulrike , Crosby Ross D. 
Published: May 2014

ABSTRACTObjectiveTo (1) determine whether childhood risk factors for early onset binge eating and purging eating disorders also predict risk for later‐onset binge eating and purging disorders, and (2) compare the utility of childhood and early adolescent variables in predicting later‐onset disorders.MethodParticipants (N = 1,383) were drawn from the Western Australian Pregnancy Cohort (Raine) Study, which has followed children from pre‐birth to age 20. Eating disorders were assessed when participants were aged 14, 17, and 20. Risk factors for early onset eating disorders have been reported previously (Allen et al., J Am Acad Child Psychiat, 48, 800–809, 2009). This study used logistic regression to determine whether childhood risk factors for early onset disorders, as previously identified, would also predict risk for later‐onset disorders (n = 145). Early adolescent predictors of later‐onset disorders were also examined.ResultsConsistent with early onset cases, female sex and parent‐perceived child overweight at age 10 were significant multivariate predictors of binge eating and purging disorders with onset in later adolescence. Eating, weight, and shape concerns at age 14 were also significant in predicting later‐onset disorders. In the final stepwise multivariate model, female sex and eating, weight, and shape concerns at age 14 were significant in predicting later‐onset eating disorders, while parent‐perceived child overweight at age 10 was not.DiscussionThere is overlap between risk factors for binge eating and purging disorders with early and later onset. However, childhood exposures may be more important for early than later onset cases. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:802–812)
Copper Complexes of N‐Donor Ligands as Artificial Nucleases
Authors: Wende Christian , Lüdtke Carsten , Kulak Nora 
Published: May 2014

AbstractThis microreview summarizes recent research in the field of artificial nucleases, in particular those based on copper(II) in an N‐donating ligand environment. This review is divided into three parts describing different ligand classes that have shown promising results in DNA cleavage chemistry: aromatic N‐donors, aliphatic N‐donors, and peptide ligands. Whereas nature has created very efficient nucleases, artificial nucleases aim at different selectivities and higher stability under various conditions. Artificial nucleases based on metal complexes comprise Lewis acidic or redox‐active metal centers allowing for either hydrolytic or oxidative DNA cleavage. The focus of our research and thus also of this microreview is copper, whose CuII ion combines both properties. Depending on the ligand scaffold and reaction conditions, either pathway or even both are thus conceivable. Those different pathways lead to molecular biological and medicinal applications.
Supramolecular Control of Biomimetic Coordination – ZnII Cavity Complexes Presenting Two Differentiated Labile Sites in cis Positions
Authors: Gout Jérôme , Rat Stéphanie , Bistri Olivia , Reinaud Olivia 
Published: May 2014

AbstractA supramolecular approach to model the active sites of metalloenzymes is to associate a cavity with a tripodal coordination core. One key feature of many enzymes is the possible binding of two different ligands in cis positions relative to each other, which has not yet been described for cavity complexes. Here, the bowl shape of resorcinarene allows such a coordination environment for ZnII complexes. A detailed NMR study with various carboxylic acids evidences size‐, shape‐, and, thus, regioselectivity for carboxylate coordination in the endo position, the exo position, or both. The coordination of diketonates unambiguously demonstrates the relative cis position of the two labile sites present in the tris(imidazole)zinc(II) bowl complex. An interesting intramolecular exchange process was also observed. Finally, a comparison with calix[6]arene‐based complexes (so‐called funnel complexes) further highlights the key role of the cavity in the control of properties of the metal ion.
Impact of surgical excision of lesions on pain in a rat model of endometriosis
Authors: Alvarez P. , Giudice L.C. , Levine J.D. 
Published: May 2014

AbstractBackgroundChronic pain is the most common and disabling feature of endometriosis. Surgical excision of endometriosis lesions provides relief but pain relapse is common. Studies in a preclinical model of endometriosis might help to unravel the role of the ectopic lesions as the source of pain. Thus, we evaluated the impact of lesion excision on mechanical hyperalgesia in a preclinical model of endometriosis pain.MethodsEndometriosis was induced by implanting autologous uterine tissue onto the gastrocnemius muscle. Surgical excision or aspiration drainage of the cystic lesion was performed at different times post‐implant and mechanical nociceptive thresholds were assessed at the site of the lesion.ResultsLesions at 2, 8 and 16 weeks post‐implant produced mechanical hyperalgesia of similar magnitude (n = 6/group). Excision of lesions (n = 6/group) produced a longer inhibition, with a magnitude and time course depending upon the timing of excision. Excision at 2 and 8 weeks produced a rapid onset marked attenuation of hyperalgesia, which returned to pre‐excision values by post‐surgical week 3. In contrast, excision of the lesion at 16 weeks produced a peak of inhibition of hyperalgesia 2 weeks post‐excision, but then the inhibition was sustained. Aspiration of fluid from cysts in the lesions briefly attenuated mechanical hyperalgesia (n = 6/group).ConclusionsIn this preclinical model, we demonstrate that endometriosis pain is alleviated by surgical excision of the ectopic lesion or drainage of its cysts, providing support for the clinical observation that endometriosis pain is dependent upon the ongoing presence of the lesions.
A well‐balanced explicit/semi‐implicit finite element scheme for shallow water equations in drying–wetting areas
Authors: Zhao Lanhao , Guo Bowen , Li Tongchun , Avital E. J. , Williams J. J. R. 
Published: May 2014

SUMMARYNumerical solutions of the shallow water equations can be used to reproduce flow hydrodynamics occurring in a wide range of regions. In hydraulic engineering, the objectives include the prediction of dam break wave propagation, fluvial floods and other catastrophic flooding phenomena, the modeling of estuarine and coastal circulations, and the design and optimization of hydraulic structures. In this paper, a well‐balanced explicit and semi‐implicit finite element scheme for shallow water equations over complex domains involving wetting and drying is proposed. The governing equations are discretized by a fractional finite element method using a two‐step Taylor–Galerkin scheme. First, the intermediate increment of conserved variable is obtained explicitly neglecting the pressure gradient term. This is then corrected for the effects of pressure once the pressure increment has been obtained from the Poisson equation. In order to maintain the ‘well‐balanced’ property, the pressure gradient term and bed slope terms are incorporated into the Poisson equation. Moreover, a local bed slope modification technique is employed in drying–wetting interface treatments. The proposed model is well validated against several theoretical benchmark tests. Copyright © 2014 John Wiley & Sons, Ltd.
Safety and efficacy of hypofractionated stereotactic body reirradiation in head and neck cancer: Long‐term follow‐up of a large series
Authors: Kress Marie‐Adele S. , Sen Neilayan , Unger Keith R. , Lominska Christopher E. , Deeken John F. , Davidson Bruce J. , Newkirk Kenneth A. , Hwang Jimmy , Harter K. William 
Published: May 2014

ABSTRACTBackgroundThe purpose of this study was to report long‐term outcomes for a large cohort of patients with head and neck squamous cell carcinoma (HNSCC) who underwent stereotactic body radiotherapy (SBRT) reirradiation.MethodsFrom 2002 to 2011, 85 patients with previously irradiated HNSCC were treated with SBRT to 94 lesions. Some underwent surgery (29%), and many were treated with induction, concurrent, and/or adjuvant chemotherapy or biologic therapy (70%).ResultsReirradiation occurred at a median interval from initial radiotherapy (RT) of 32 months. Median follow‐up for survivors was 17.3 months. Two‐year Kaplan–Meier estimates of overall survival (OS) and locoregional control for patients and lesions treated with curative intent were 24% and 28%, respectively. Interval from initial RT to SBRT of 2 years or more was associated with improved OS (p = .019). Five patients had grade 3 or higher late toxicity (5.9%).ConclusionSBRT reirradiation results in limited toxicity. Further research is needed to refine optimal roles for SBRT and intensity‐modulated radiotherapy (IMRT) reirradiation. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1403–1409, 2015
Unknown primary mucoepidermoid carcinoma: Diagnosis and treatment
Authors: Trosman Samuel , Chute Deborah , Wood Benjamin , Lamarre Eric 
Published: May 2014

AbstractBackgroundMucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor. The majority of MECs occur in major or intraoral minor salivary glands. Herein, we present a case of MEC metastatic to cervical lymph nodes with an unknown primary site and discuss diagnostic and treatment options.Methods and ResultsThe patient was a 43‐year‐old man who presented with a large right‐sided neck mass. Excisional biopsy demonstrated MEC involving multiple lymph nodes. Subsequent positron emission tomography (PET)/CT and multiple biopsies of potential primary sites failed to localize the primary tumor. The patient was treated with radiation to the ipsilateral neck and parotid/submandibular glands and has no evidence of disease 1 year after completion of treatment.ConclusionMEC presenting as cervical lymph node metastasis with an undiagnosed primary site is extremely rare. We report results of our literature review and provide a rationale for our experience in treating unknown primary MEC. © 2014 Wiley Periodicals, Inc. Head Neck 37: E22‐E25, 2015
New Antiproliferative Tricyclic Sesquiterpenoid from the Leaves of Ocimum sanctum
Authors: Singh Deepika , Kumar Chaudhuri Prabir , Darokar Mahendra P. 
Published: May 2014

AbstractA new tricyclic sesquiterpenoid 2‐(hydroxymethyl)‐5,5,9‐trimethyltricyclo[7.2.0.03,6]undecan‐2‐ol (1), was identified from the leaves of Ocimum sanctum, and its structure was elucidated by extensive NMR and ESI‐MS analyses. Compound 1 was found to have potent antiproliferative activity against the MCF‐7 cell line.
In Situ analysis of CO2 laser irradiation on controlling progression of erosive lesions on dental enamel
Authors: Lepri Taísa Penazzo , Scatolin Renata Siqueira , Colucci Vivian , De Alexandria Adílis Kalina , Maia Lucianne Cople , Turssi Cecília Pedroso , Corona Silmara Aparecida Milori 
Published: May 2014

ABSTRACTThe present study aimed to evaluate in situ the effect of CO2 laser irradiation to control the progression of enamel erosive lesions. Fifty‐six slabs of bovine incisors enamel (5 × 3 × 2.5 mm3) were divided in four distinct areas: (1) sound (reference area), (2) initial erosion, (3) treatment (irradiated or nonirradiated with CO2 laser), (4) final erosion (after in situ phase). The initial erosive challenge was performed with 1% citric acid (pH = 2.3), for 5 min, 2×/day, for 2 days. The slabs were divided in two groups according to surface treatment: irradiated with CO2 laser (λ = 10.6 µm; 0.5 W) and nonirradiate. After a 2‐day lead‐in period, 14 volunteers wore an intraoral palatal appliance containing two slabs (irradiated and nonirradiated), in two intraoral phases of 5 days each. Following a cross‐over design during the first intraoral phase, half of the volunteers immersed the appliance in 100 mL of citric acid for 5 min, 3×/day, while other half of the volunteers used deionized water (control). The volunteers were crossed over in the second phase. Enamel wear was determined by an optical 3D profilometer. Three‐way ANOVA for repeated measures revealed that there was no significant interaction between erosive challenge and CO2 laser irradiation (P = 0.419). Erosive challenge significantly increased enamel wear (P = 0.001), regardless whether or not CO2 laser irradiation was performed. There was no difference in enamel wear between specimens CO2‐laser irradiated and non‐irradiated (P = 0.513). Under intraoral conditions, CO2 laser irradiation did not control the progression of erosive lesions in enamel caused by citric acid. Microsc. Res. Tech. 77:586–593, 2014. © 2014 Wiley Periodicals, Inc.
Paradoxical impact of the remnant pancreatic volume and infectious complications on the development of nonalcoholic fatty liver disease after pancreaticoduodenectomy
Authors: Sato Rie , Kishiwada Masashi , Kuriyama Naohisa , Azumi Yoshinori , Mizuno Shugo , Usui Masanobu , Sakurai Hiroyuki , Tabata Masami , Yamada Tomomi , Isaji Shuji 
Published: May 2014

AbstractBackgroundThe aim of the present study was to evaluate perioperative risk factors for development of nonalcoholic fatty liver disease (NAFLD) after pancreaticoduodenectomy (PD), paying special attention to remnant pancreatic volume (RPV) and postoperative infection.MethodsWe reviewed the charts of 110 patients who had been followed more than 6 months after PD. These patients were classified into the two groups according to RPV measured by CT volumetry at one month: large‐volume group (LVG) (10 ml or more, n = 75) and small‐volume group (SVG) (less than 10 ml, n = 35).ResultsNonalcoholic fatty liver disease developed in 44 (40.0%), being significantly higher in SVG than in LVG: 54.2% vs. 33.3% (P = 0.037). SVG was characterized as significantly higher incidence of pancreatic adenocarcinoma, while LVG was characterized as significantly higher incidences of soft pancreas, postoperative infection and pancreatic fistula. In LVG, the incidence of NAFLD was significantly higher in patients with suspicion of infection than in those without it: 45.2% vs. 18.1% (P = 0.014), while not different in SVG. By multivariate analysis, independent risk factor was determined as RPV and suspicion of infection in the whole patients, and in LVG it was suspicion of infection, while in SVG it was not identified.ConclusionAfter PD, RPV and status of postoperative infection paradoxically influenced the development of NAFLD.
Development of a discharge readiness report within the electronic health record—A discharge planning tool
Authors: Tyler Amy , Boyer Ann , Martin Sara , Neiman Jenae , Bakel Leigh Anne , Brittan Mark 
Published: May 2014

BACKGROUNDWith increasingly complex pediatric inpatients, efficient and effective hospital discharge requires optimal interdisciplinary care coordination and communication. We describe the development of a discharge readiness report (DRR) for the electronic health record (EHR), an integrated summary of discharge‐related information organized into a highly visible and easily accessible report.METHODSWe used interviews and process mapping to understand the roles of all disciplines involved in discharge planning and identified key drivers affecting our aim of designing a discharge tool in the EHR. Based on identified key drivers, we designed the DRR and made changes to the report using rapid improvement cycles. The final report includes information necessary for discharge planning organized into 4 domains: potential barriers to discharge, transitional care, home care, and discharge criteria.RESULTSThe DRR was activated in June 2012. As planned, the final product incorporated previously existing discharge‐related information from within the EHR, organized into 1 report. Shortly after its introduction, the DRR was included in daily care coordination rounds (CCRs) for medical and medical subspecialty patients. End users found the report to be completely populated and accurate. We measured time to completion of CCRs and found no difference between duration of CCRs pre‐ and postuse of the DRR.CONCLUSIONSGiven widespread adoption, EHRs should be optimized to improve healthcare delivery. A discharge planning tool in the EHR may improve the efficiency and effectiveness of care transitions by allowing for proactive discharge planning and improved interdisciplinary communication. Journal of Hospital Medicine 2014;9:533–539. © 2014 Society of Hospital Medicine
Significant work events and counterproductive work behavior: The role of fairness, emotions, and emotion regulation
Authors: Matta Fadel K. , Erol‐Korkmaz H. Tuğba , Johnson Russell E. , Biçaksiz Pinar 
Published: May 2014

SummaryIn this diary study, we investigated multi‐level predictors of daily counterproductive work behavior (CWB) relying on the theoretical frameworks of affective events theory and the emotion‐centered model of CWB. We assessed significant work events, event‐based fairness perceptions, negative emotional reactions to work events, and employee CWB over a 10‐day period. We tested within‐person relations predicting CWB, and cross‐level moderating effects of two emotion regulation strategies (suppression and reappraisal). Results from a multi‐level path analysis revealed that significant work events had both direct and indirect effects on negative emotional reactions. Further, negative emotional reactions in turn mediated the relationships between significant work events and all forms of daily CWB as well as the relationship between event‐based fairness perceptions and daily CWB‐O. Results also supported the moderating role of reappraisal emotion regulation strategy on relations between significant work events and negative emotional reactions. Less support, however, was found for the moderating influence of suppression on the link between negative emotional reactions and CWB. Among the broad work event categories we identified, our supplemental analyses revealed that negative work events involving interactions with supervisors elicited the highest levels of employee negative emotional reactions. We discuss the theoretical and practical implications of these findings. Copyright © 2014 John Wiley & Sons, Ltd.
Characterization of surface winds over the Iberian Peninsula
Authors: Lorente‐Plazas R. , Montávez J. P. , Jimenez P. A. , Jerez S. , Gómez‐Navarro J. J. , García‐Valero J. A. , Jimenez‐Guerrero P. 
Published: May 2014

ABSTRACTThis work presents a characterization of the surface wind climatology over the Iberian Peninsula (IP). For this objective, an unprecedented observational database has been developed. The database covers a period of 6 years (2002–2007) and consists of hourly wind speed and wind direction data recorded at 514 automatic weather stations. The original observations underwent a quality control process to remove rough errors from the data set. In the first step, the annual and seasonal mean behaviour of the wind field are presented. This analysis shows the high spatial variability of the wind as a result of its interaction with the main orographic features of the IP. In order to simplify the characterization of the wind, a clustering procedure was applied to group the observational sites with similar temporal wind variability. A total of 20 regions are identified. These regions are strongly related to the main landforms of the IP. The wind behaviour of each region, characterized by the wind rose (WR), annual cycle (AC) and wind speed histogram, is explained as the response of each region to the main circulation types (CTs) affecting the IP. Results indicate that the seasonal variability of the synoptic scale is related with intra‐annual variability and modulated by local features in the WRs variability. The wind speed distribution not always fit to a unimodal Weibull distribution consequence of interactions at different atmospheric scales. This work contributes to a deeper understanding of the temporal and spatial variability of surface winds. Taken together, the wind database created, the methodology used and the conclusion extracted are a benchmark for future works based on the wind behaviour.
Harnessing Allostery: A Novel Approach to Drug Discovery
Authors: Lu Shaoyong , Li Shuai , Zhang Jian 
Published: May 2014

AbstractAllostery is the most direct and efficient way for regulation of biological macromolecule function, ranging from the control of metabolic mechanisms to signal transduction pathways. Allosteric modulators target to allosteric sites, offering distinct advantages compared to orthosteric ligands that target to active sites, such as greater specificity, reduced side effects, and lower toxicity. Allosteric modulators have therefore drawn increasing attention as potential therapeutic drugs in the design and development of new drugs. In recent years, advancements in our understanding of the fundamental principles underlying allostery, coupled with the exploitation of powerful techniques and methods in the field of allostery, provide unprecedented opportunities to discover allosteric proteins, detect and characterize allosteric sites, design and develop novel efficient allosteric drugs, and recapitulate the universal features of allosteric proteins and allosteric modulators. In the present review, we summarize the recent advances in the repertoire of allostery, with a particular focus on the aforementioned allosteric compounds.
Low vitamin D status throughout life results in an inflammatory prone status but does not alter bone mineral or strength in healthy 3‐month‐old CD‐1 male mice
Authors: Jahani Raha , Fielding Kristina A. , Chen Jianmin , Villa Christopher R. , Castelli Laura M. , Ward Wendy E. , Comelli Elena M. 
Published: May 2014

ScopeThe aim of this study was to assess if exposure to different levels of dietary vitamin D pre‐ and postweaning impacts the intestinal‐bone axis.Methods and resultsFemale CD1 mice were exposed to high (5000 IU vitamin D3/kg diet, H) or low (25 IU vitamin D3/kg diet, L) vitamin D diet (modified AIN‐93G) during pregnancy and lactation. At weaning (postnatal day 21), a subset of the male offspring was sacrificed and another subset was assigned to receive their dams’ respective diet (HH and LL) or the other diet (HL and LH) until sacrifice at 3 months of age. Lower level of vitamin D resulted in reduced vitamin D receptor and increased expression of pro‐inflammatory genes in the colon at 3 months, lower numbers of colonic Bacteroides/Prevotella at postnatal day 21 and higher serum LPS concentration at adulthood. There was a programming effect of vitamin D on LPS levels. Mineral content, density, and strength of femurs and vertebrae were not affected.ConclusionOur findings suggest that low vitamin D exposure results in an inflammatory‐prone status that may contribute to or be a risk factor for several diseases including inflammatory bowel disease, obesity, diabetes, and cardiovascular diseases.