bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chrysosporium articulatum mimicking Trichophyton spp. infection in a cat: a case presentation and literature review
Authors: Kizerwetter-Świda Magdalena , Bąk Iwona , Biegańska Małgorzata Justyna , Dembele Kourou , Chrobak-Chmiel Dorota 
Published: August 2024

Abstract
Background
Dermatophytosis is a common skin infection of cats and many other animals. A reliable diagnosis is crucial because of the zoonotic potential of dermatophytes. The routine mycological diagnostic procedures for dermatophytosis are widely known, but in the case of some isolates, identification based on phenotypic characteristics may be incorrect. Infections caused by Chrysosporium spp. are usually described in reptiles, but in other animals they are uncommon.

Case presentation
This study presents a description of a cat with dermatological lesions, that was mistakenly diagnosed with Trichophyton spp. dermatophytosis. Clinical material for mycological examination was collected from alopecic areas on the back of the neck, the ventral abdomen, and the hindlimbs. The initial identification based on phenotypic properties indicated Trichophyton spp. The result of the MALDI-ToF MS allowed the exclusion of the Trichophyton genus. Ultimately, the correct identification as Chrysosporium articulatum was obtained based on the sequencing of ribosomal genes.

Conclusions
Interpretation of the results of the mycological examination of samples collected from animals’ skin or hair shafts is always challenging. Thus, careful consideration of the primary cause of the clinical lesions observed on the skin is mandatory, and the culture results are worth supporting by molecular methods.
Dietary niacin Intake and its association with all-cause and cardiovascular mortality rates in individuals with metabolic syndrome
Authors: Fu Yuqing , Xu Cong , Wu Guifu 
Published: August 2024

Abstract
Background
Individuals with metabolic syndrome face elevated cardiovascular and mortality risks, and there is ongoing debate regarding the cardiovascular effects of niacin and its impact on the prognosis of metabolic syndrome.

Exposure
Levels of dietary niacin intake based on 24-hour dietary recall.

Methods
Kaplan-Meier survival curves were used to compare survival status among quartiles of dietary niacin intake. Weighted Cox proportional hazards models and restricted cubic splines were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the risk of all-cause and CVD mortality associated with the exposure.

Results
This cohort study included 8,744 participants, and during a median follow-up period of 106 months, 1,552 (17.7%) deaths were recorded, with 511 attributed to cardiovascular disease. Kaplan-Meier curves comparing quartiles of dietary niacin intake showed significant differences in both all-cause and cardiovascular mortality rates (log-rank p < 0.001). In the fully adjusted model, the highest quartile of dietary niacin intake was associated with HRs of 0.68 (95% CI: 0.54, 0.87, P = 0.002) for all-cause mortality and 0.63 (95% CI: 0.39, 0.78, P < 0.001) for cardiovascular mortality.

Conclusion
The results of this cohort study suggest that higher dietary niacin intake is associated with reduced cardiovascular and all-cause mortality risks in the metabolic syndrome population. Furthermore, there appears to be a dose-response relationship between dietary niacin intake and the risks of all-cause and cardiovascular mortality.
A biomechanical study comparing the compression force and osseous area of contact of two screws fixation techniques used in ankle joint arthrodesis model
Authors: Weigert Annabelle , Kistler Manuel , Bauer Leandra , Kussmaul Adrian C. , Keppler Alexander M. , Holzapfel Boris Michael , Wegener Bernd 
Published: August 2024

Abstract
Introduction
Arthrodesis of a (diseased) ankle joint is usually performed to achieve pain relief and stability. One basic principle of arthrodesis techniques includes rigid fixation of the surfaces until union. It seems plausible that stable anchoring and homogeneous pressure distribution should be advantageous, however, it has not been investigated yet. The aim is to achieve uniform compression, as this is expected to produce favorable results for the bony fusion of the intended arthrodesis. Numerous implants with different biomechanical concepts can be used for ankle fusion. In this study, headless compression screws (HCS, DePuy Synthes, Zuchwil, Switzerland) were compared biomechanically to an alternative fixation System, the IOFix device (Extremity Medical, Parsippany, NJ, USA) in regard to the distribution of the compression force (area of contact) and peak compression in a sawbone arthrodesis-model (Sawbones® Pacific Research Laboratories, Vashon, WA, USA).
This study aims to quantify the area of contact between the bone interface that can be obtained using headless compression screws compared to the IOFix. In current literature, it is assumed, that a large contact surface with sufficient pressure between the bones brings good clinical results. However, there are no clinical or biomechanical studies, that describe the optimal compression pressure for an arthrodesis.

Material and methods
Two standardized sawbone blocks were placed above each other in a custom-made jig. IOFix and headless compression screws were inserted pairwise parallel to each other using a template for a uniform drilling pattern. All screws were inserted with a predefined torque of 0.5 Nm. Pressure transducers positioned between the two sawbone blocks were compressed for the measurement of peak compression force, compression distribution, and area of contact.

Results
With the IOFix, the compression force was distributed over significantly larger areas compared to the contact area of the HCS screws, resulting in a more homogenous contact area over the entire arthrodesis surface. Maximum compression force showed no significant difference.

Conclusion
The IOFix system distributes the compression pressure over a much larger area, resulting in more evenly spread compression at the surface. Clinical studies must show whether this leads to a lower pseudarthrosis rate.
Training approaches for the dissemination of clinical guidelines for NSSI: a quasi-experimental trial
Authors: Koenig Elisa , Hoffmann Ulrike , Fegert Jörg M. , Keller Ferdinand , Sicorello Maurizio , Spohrs Jennifer , Kraus Laura , Nickel Sandra , Schmahl Christian , Abler Birgit , In-Albon Tina , Koenig Julian , Ougrin Dennis , Kaess Michael , Plener Paul L. ,   the Star-Consortium, Sittenberger Elisa , Schischke Lisa , Geprägs Alina , Liebhart Isabell , Witt Andreas , Sachser Cedric , Brown Rebecca , Münch Vera , König Elisa , Niedtfeld Inga , Zähringer Jenny , Isik Hasan-Hüseyin , Koelch Michael , Reis Olaf , Michelsen Anna , Chiocchetti Andreas G. , Lindlar Silvia , Waltes Regina , Mössner Markus , van der Venne Patrice , Höper Saskia , Flach Elisa , Edinger Alexandra , Bauer Stephanie , Mattern Margarete , Herpertz Sabine , Ebner Ulrich , Santangelo Philip S. 
Published: August 2024

AbstractBackgroundNon-suicidal self-injury (NSSI) is of high clinical relevance due to its high prevalence and negative long-term implications. In 2016, the German consensus-based clinical guidelines for diagnostic, assessment and treatment of NSSI in childhood and adolescence were published. However, research indicates that clinical guidelines are often poorly implemented in clinical practice. One crucial part of this process is the training of healthcare professionals to transfer knowledge and capacities to bring guideline recommendations into clinical practice.MethodsThe effect of three different dissemination strategies (printed educational material, e-learning, and blended-learning) on the NSSI guidelines´ recommendations was examined among 671 physicians and psychotherapists via an online-survey. The quasi-experimental study included three measurement points (before the training, after the training, 3-month follow-up) and mixed effects models were used to test for changes in knowledge, competences and attitudes toward NSSI and treatment. Moreover, the transfer of gained competences to practical work and user satisfaction were reviewed.ResultsWith all three training formats, the intended changes of the outcome variables could be observed. Hereby, the printed educational material condition showed the lowest improvement in the scores for the ‘negative attitudes toward NSSI and those who self-injure’. The training effect remained stable throughout the follow-up measurement. The highest application rate of acquired intervention techniques in clinical practice was reported for the blended-learning condition. For all three training strategies, user satisfaction was high and evaluation of training quality was positive, with printed educational material receiving the lowest and blended-learning the highest evaluations.ConclusionsIn summary, all three training formats were perceived to be of high quality and seem to be suited to cover the needs of a heterogeneous group of physicians and psychotherapists. The choice of training method could be driven by considering which training goals are desired to be achieved and by the benefit-cost ratio allowing for tailored training approaches.
Recent advances in essential oils and their nanoformulations for poultry feed
Authors: Movahedi Fatemeh , Nirmal Nilesh , Wang Pengyuan , Jin Hongping , Grøndahl Lisbeth , Li Li 
Published: August 2024

AbstractAntibiotics in poultry feed to boost growth performance are becoming increasingly contentious due to concerns over antimicrobial resistance development. Essential oils (EOs), as natural, plant-derived compounds, have demonstrated antimicrobial and antioxidant properties. EOs may potentially improve poultry health and growth performance when included in poultry feed. Nevertheless, the incorporation of EOs as nutritional additives is hindered by their high volatility, low water solubility, poor intestinal absorption, and sensitivity to environmental conditions. Recently, nanoencapsulation strategies using nanoformulations have emerged as a potential solution to these challenges, improving the stability and bioavailability of EOs, and enabling targeted delivery in poultry feed. This review provides an overview of the antioxidant and antibacterial properties of EOs, the current limitations of their applications in poultry feed, and the recent advancements in nano-engineering to overcome these limitations. Furthermore, we outline the potential future research direction on EO nanoformulations, emphasizing their promising role in advancing sustainable poultry nutrition.Highlights• Essential oils (EOs) are known as powerful antioxidants and antibacterial agents.• EOs have a high potential to replace antibiotics as feed additives.• Nanoformulations of EOs have shown improved bioactivity and storage stability of EOs.• Nanoformulation promotes the bioavailability and gut adsorption of EOs as feed additives.
Investigating AVHs narratives through text analysis: the proposal of Dialogic Science for tackling stigmatization
Authors: Bassi Davide , Orrù Luisa , Moro Christian , Salvarani Davide , Turchi Gian Piero 
Published: August 2024

Abstract
Background
Auditory verbal hallucinations (AVHs) are a significant symptom of various psychological conditions, often stigmatized and misunderstood. Moving beyond traditional psychological, psychotherapeutic and psychiatric approaches, recent research shifts focus on understanding AVHs through community perspectives and the resulting stigmatization. This research approach is crucial for better support and understanding of AVHs, however it still suffers from the lack of a rigorous and shared methodology for studying and reducing stigma.

Methods
Our study, part of the Italian “PsicoVoice” project, aims to investigate community discourses on AVHs, in order to observe whether and to what extent they are drivers of stigmatisation processes. Engaging 268 participants with direct (hearers) and indirect (such as relatives and professionals) experiences of AVHs, the research analyzes a corpus of 54,320 instances using MADIT: a text analysis methodology which is both qualitative and quantitative. MADIT allows for an innovative examination of the rhetorical-argumentative structures within narratives, producing an index for measuring the narratives’ practical impact on people’ interactions around AVHs.

Results
The analysis revealed that the overall community discourses are predominantly shaped by absolute and personal belief-driven modalities. This way of conveying sense, even with non-necessarily-judgmental words, contributes to a stigmatizing environment for individuals with AVHs, cementing a static representation dominated by personal opinions and reducing the potential for more nuanced, diverse interactions about AVHs.

Conclusion
The study’s findings underscore the importance of addressing the narrative structures within community discourses. By intervening in these narratives, there is potential to shift towards a less stigmatizing social construction of AVHs. Thus, the article concludes using the results to provide some insights on how to generate these interventions. This approach could significantly impact how communities understand and interact with individuals experiencing AVHs, promoting more inclusive and supportive environments and interventions.
Teplizumab’s immunomodulatory effects on pancreatic β-cell function in type 1 diabetes mellitus
Authors: Kokori Emmanuel , Olatunji Gbolahan , Ogieuhi Ikponmwosa Jude , Aboje John Ehi , Olatunji Doyin , Aremu Sikiru Ademola , Igwe Stephen Chukwuemeka , Moradeyo Abdulrahmon , Ajayi Yusuf Ismaila , Aderinto Nicholas 
Published: August 2024

AbstractThis review explores the immunomodulatory potential of Teplizumab and its impact on pancreatic β-cell function in T1D. Characterized by the autoimmune destruction of insulin-producing beta cells, T1D’s management involves maintaining glycemic control through exogenous insulin. Teplizumab, a humanized monoclonal antibody targeting the CD3 antigen, has shown promise in delaying T1D onset and preserving residual β-cell function. The review employs a narrative approach, synthesizing evidence from diverse clinical trials and studies gathered through a meticulous literature search. It scrutinizes Teplizumab’s mechanisms of action, including its influence on autoreactive CD8 + T cells and regulatory T cells, offering insights into its immunological pathways. The synthesis of findings from various trials demonstrates Teplizumab’s efficacy in preserving C-peptide levels and reducing exogenous insulin requirements, particularly in recent-onset T1D. Considering Teplizumab’s real-world implications, the paper addresses potential obstacles, including side effects, patient selection criteria, and logistical challenges. It also emphasizes exploring combination therapies and personalized treatment strategies to maximize Teplizumab’s benefits. The review contributes a nuanced perspective on Teplizumab’s clinical implications and future directions in T1D management, bridging theoretical understanding with practical considerations.
Financial ambiguity and oil prices
Authors: Ayoub Mahmoud , Qadan Mahmoud 
Published: August 2024

AbstractRecent theoretical developments in economics distinguish between risk and ambiguity (Knightian uncertainty). Using state-of-the-art methods with intraday stock market data from February 1993 to February 2021, we derive financial ambiguity and empirically examine the effect of shocks to it on the price and volatility of crude oil. We provide evidence that ambiguity carries important information about future oil returns and volatility perceived by investors. We validate these results using Granger causality and in-sample and out-of-sample forecasting tests. Our findings reveal that financial ambiguity is a possible factor that explains future drops in oil prices and their increased variability. Our findings will benefit scholars and investors interested in how financial ambiguity shapes short-term oil prices.
Stigma and depression among obese infertile women: a cross-sectional study
Authors: Koç Özlem , Karakoç Hediye , Ersöğütçü Filiz 
Published: August 2024

Abstract
Background
Obesity causes infertility through various pathways, including disruption of ovarian follicular development, qualitative and quantitative development of the oocyte, fertilization, embryo development, and implantation. In traditional societies such as Türkiye, having children is a determinant of social status. Stigma is defined as a negative sense of social difference from others. Depression is a common health problem in infertile women due to the stressful nature of treatment procedures, fear of treatment failure, and the patient’s inability to become pregnant. In this cross-sectional study, the sample consisted of 161 infertile women from an infertility outpatient clinic of a university hospital in Eastern Turkey.

Results
It was determined that depression scores had a strong positive correlation with stigma scores. In the multiple regression analysis performed to evaluate the effects of five independent variables determined to have an effect on depression scores, it was seen that the independent variables explained depression levels by 80%.

Conclusion
The findings of this study suggest that stigma and depression are significant factors affecting the psychosocial and emotional well-being of obese women experiencing infertility. These results underscore the potential need for more comprehensive psychosocial support and assessment for women experiencing infertility related to obesity. Obese patients should be informed about the importance of pre-pregnancy weight reduction and should be encouraged to lose weight before the treatment to reduce the poor obstetrical outcomes due to obesity. Additionally, evidence-based guidelines should be prepared for assisted reproductive techniques for fertility treatment in obese infertile women.
β-Cell Dedifferentiation in HOMA-βlow and HOMA-βhigh Subjects
Authors: Kang Fuyun , Zhang Zhuo , Fu Hui , Sun Jiajun , Zhang Jun , Wang Qidi 
Published: August 2024

Abstract

Context
β-Cell dedifferentiation ratio is increased in type 2 diabetes; but its direct link to in vivo β-cell function in human remains unclear.

Objective
The present study was designed to investigate whether β-cell dedifferentiation in situ was closely associated with β-cell function in vivo and to identify targets crucial for β-cell dedifferentiation/function in human.

Methods
We acquired homeostasis model assessment of β-cell function (HOMA-β) values, calculated the number of hormone-negative endocrine cells, and evaluated important markers and novel candidates for β-cell dedifferentiation/function on paraneoplastic pancreatic tissues from 13 patients with benign pancreatic cystic neoplasm or intrapancreatic accessory spleen.

Results
Both the β-cell dedifferentiation ratio and the dedifferentiation marker (Aldh1a3) were inversely related to in vivo β-cell function (HOMA-β) and in situ β-cell functional markers Glut2 and Ucn3 in humans. Moreover, the islets from HOMA-βlow subjects were manifested as (1) increased β-cell dedifferentiation ratio, (2) enriched dedifferentiation maker Aldh1a3, and (3) lower expression of Glut2 and Ucn3 compared with those from HOMA-βhigh subjects. We found that basic leucine zipper transcription factor 2 (Bach2) expression was significantly induced in islets from HOMA-βlow patients and was positively correlated with the ratio of β-cell dedifferentiation in humans.

Conclusion
Our findings emphasize the contribution of β-cell dedifferentiation to β-cell dysfunction in humans. Bach2 induction in β-cells with higher frequency of dedifferentiation observed in HOMA-βlow subjects reinforces its distinctive role as a pharmaceutical target of β-cell dedifferentiation for the treatment of people with diabetes.
A protocol for the longitudinal investigation of cancer related fatigue in head and neck cancer with an emphasis on the role of physical activity
Authors: Narasimhan Prahalad , Levy Andrew R. , Rogers Simon N. , Schache Andrew G. , Patterson Joanne M. , Williams Nefyn H. , Brooker Rachel C. , Midgley Adrian W. 
Published: August 2024

Background and aim
Cancer related fatigue significantly impairs the ability to undertake sustained physical activity across the domains of daily living, work and recreation. The purpose of this study is to monitor cancer related fatigue and the factors affected or caused by it for 12 months in head and neck cancer patients following their diagnosis. Their perceptions of how fatigue might affect their activity levels in addition to identifying avenues to improve engagement with physical activity will be also explored.

Methods
A single centre longitudinal mixed-methods study will be conducted. Forty head and neck cancer patients will be recruited over 6 months following the confirmation of their treatment plan, after which fatigue and physical activity will be assessed at four time points over 12 months. Additionally, other factors which influence fatigue such as body composition, blood counts, systemic inflammation levels, haemoglobin concentration, thyroid function, sleep quality, cardiorespiratory fitness and upper and lower extremity strength will be measured to understand how the multifactorial problem of fatigue may evolve over time and influence physical activity levels. Semi-structured interviews will be conducted after treatment completion and at end of twelve months which will analyse the participants fatigue experiences, understand how their perceived fatigue may have impacted physical activity and report the factors which may improve engagement with physical activity during cancer. Quantitative data will be analysed and reported using standard descriptive statistics and post-hoc pairwise comparisons. The changes in outcome measures across time will be analysed using the MIXED procedure in SPSS software. Statistical significance will be accepted at p<0.05. Qualitative data will be analysed using the Interpretative Phenomenological Approach using the NVivo software.

Discussion
The results from this study may help inform the planning and delivery of appropriately timed interventions for the management of cancer related fatigue.
Spaceengine como ferramenta didática para o ensino de Astronomia:
Authors: Almeida Uiliam , Claudino Ferreira Roberto , Maria Hetkowski Tânia , Lemos Moreira Mariana , Oliveira Souza Ernande , Da Silva Cruz Maria Eduarda 
Published: August 2024

O presente trabalho propôs uma Sequência Didática voltada ao 9° do Ensino Fundamental na área de ciências dentro do tema da Astronomia. Para desenvolve – lá adotamos como ferramenta didática principal o software astronômico SpaceEngine. Apresentamos a proposta no II Seminário Virtual de Astronomia da UESB, participaram como convidados docentes, discentes de várias universidades e estudantes do ensino médio. As habilidades da BNCC foram o ponto de partida para construção da sequência didática. Na apresentação mostramos como se executaria a dinâmica da proposta com a apresentação da parte operacional e didática da exploração do SpaceEngine aplicado ao conteúdo em tela. Por fim, foi fornecido um questionário on-line para a coleta de dados. Os resultados analisados nesse artigo expressam as respostas de 22 estudantes de licenciatura e nelas indicam que a maioria dos participantes usariam a sequência didática em sua originalidade o que mostra que o objetivo da pesquisa foi alcançado de forma satisfatória. O trabalho gerou inúmeras possibilidades de ampliação e melhorias sugeridas pelos participantes convidados do evento.