bluuebunny/crossref_metadata_2025_split huggingface dataset:
H19 lncRNA triggers ferroptosis, exacerbating ox-LDL-induced artery endothelial cell damage in vitro
Authors: Tang Feng , Tian Long-hai , Zhu Xiao-han , Yang Sen , Zeng Huan , Yang Yong-yao 
Published: July 2024

BACKGROUND: The precise association between lncRNA H19 and ferroptosis in the context of atherosclerosis remains uncertain. OBJECTIVE: This study is to clarify the underlying process and propose novel approaches for the advancement of therapeutic interventions targeting atherosclerosis. METHODS: Assessment of ferroptosis, which entails the evaluation of cell viability using CCK-8 and the quantification of intracellular MDA, GSH, and ferrous ions. Simultaneously, the protein expression levels of assessed by western blot analysis, while the expression level of lncRNA H19 was also determined. Furthermore, HAECs that were cultured with ox-LDL were subjected to Fer-1 interference. HAECs were exposed to ox-LDL and then transfected with H19 shRNA and H19 overexpression vector pcDNA3.1. The level of ferroptosis in the cells was then measured. Then, HAECs were subjected to incubation with ox-LDL, followed by transfection with H19 shRNA and treated with Erastin to assess the levels of ferroptosis, cell viability, and inflammatory factor production. and the ability for blood vessel development. RESULTS: The survival rate of HAECs in the ox-LDL group was much lower. Ox-LDL resulted in an upregulation of ACSL4 expression in HAECs, while the expression of SLC7A11 and GPX4 decreased. CONCLUSIONS: lncRNA H19 enhances ferroptosis and exacerbates arterial endothelial cell damage induced by LDL.
Association of Statin Use with Dementia Risk Among Older Adults in Japan: A Nested Case-Control Study Using the LIFE Study
Authors: Ge Sanyu , Kitamura Tetsuhisa , Zha Ling , Komatsu Masayo , Komukai Sho , Murata Fumiko , Maeda Megumi , Gon Yasufumi , Kimura Yasuyoshi , Kiyohara Kosuke , Sobue Tomotaka , Fukuda Haruhisa 
Published: July 2024

Background: Previous studies have shown a possible association between statin use and a decreased risk of dementia, but the association has not been sufficiently established, especially in the super-aging society of Japan. Objective: This study aimed to determine the association between statin use and the risk of dementia among Japanese participants aged> =65 years old. Methods: Data from the Longevity Improvement and Fair Evidence (LIFE) Study were utilized, including medical and long-term care (LTC) claim data from 17 municipalities between April 2014 and December 2020. A nested case-control study was conducted with one case matched to five controls based on age, sex, municipality, and year of cohort entry. We used a conditional logistic regression model to calculate the odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: This study included 57,302 cases and 283,525 controls, with 59.7% of the participants being woman. After adjusting for potential confounders, statin use was associated with a lower risk of dementia (OR, 0.70; 95% CI: 0.68–0.73) and Alzheimer’s disease (OR: 0.66; 95% CI: 0.63–0.69). Compared with non-users, the ORs of dementia were as follows: 1.42 (1.34–1.50) for 1–30 total standardized daily dose (TSDD), 0.91 (0.85–0.98) for 31–90 TSDD, 0.63 (0.58–0.69) for 91–180 TSDD, and 0.33 (0.31–0.36) for >180 TSDD in dose-analysis. Conclusions: Statin use is associated with a reduced risk of dementia and Alzheimer’s disease among older Japanese adults. A low cumulative statin dose is associated with an increased risk of dementia, whereas a high cumulative statin dose is a protective factor against dementia.
Obstructive Sleep Apnea Among Patients with Mild Cognitive Impairment
Authors: Schwerthöffer Dirk , Haselwarter Tim , Grimmer Timo 
Published: July 2024

Background: Obstructive sleep apnea (OSA) is associated with cognitive disorders, but little is known about prevalence of co-occurring OSA and mild cognitive impairment (MCI) as well as about co-occurring OSA and Alzheimer’s disease (AD). Pathophysiological models integrating OSA, cognitive deficits and neurodegeneration remain speculative. Findings in this area could contribute to the knowledge about pathophysiological processes in cognitive disorders and neurodegenerative processes, be helpful for the diagnosis of cognitive disorders and provide approaches for the treatment of cognitive disorders. Objective: Examining the prevalence of OSA and patterns of cognitive deficits as well as AD biomarker profiles associated with OSA in a cohort of 104 MCI patients. Methods: Assessments used include: respiratory polygraphy, The Consortium to Establish a Registry for Alzheimer’s Disease Neuropsychological Battery (CERAD NB), Tau, phosphoTau181, amyloid-β-1–42/1–40, 18F-fluorodeoxyglucose positron emission tomography (F18-FDG-PET). Results: Prevalence of OSA of any severity: 58,7% (Apnea Hypopnea Index (AHI)≥5/h), OSA in a moderate-to-severe extent (AHI≥15/h): 25%. Only 13.1% of MCI patients with OSA reported daytime sleepiness. MCI-OSA patients showed no specific neuropsychological pattern. Presence of OSA was not associated with specific AD biomarker profiles in the whole study group besides a positive association between AD positivity in an AD biomarker sub cohort. Conclusions: OSA is highly prevalent in patients with MCI. It might often remain undiagnosed as only a small number of MCI-OSA patients report daytime sleepiness. OSA could contribute to MCI symptoms and even to AD pathology. Further research is needed to validate these findings and to investigate possible pathophysiological relationships between OSA and MCI as well as between OSA and AD.
Oxygen saturation and work of breathing indices in preterm infants with bronchopulmonary dysplasia compared to healthy preterm infants at discharge
Authors: Kovatis K. , Mackley A. , Traczykiewicz S. , Subedi K. , Rahman T. , Shaffer T.H. 
Published: July 2024

BACKGROUND: Thoracoabdominal asynchrony (TAA) is commonly seen in preterm infants. Respiratory inductive plethysmography (RIP) is a noninvasive way to objectively assess work of breathing (WOB) indices. The impact of bronchopulmonary dysplasia (BPD) on TAA at discharge has not been established. The aim of this study is to compare WOB indices in premature infants with a diagnosis of BPD to premature infants without a diagnosis of BPD at discharge. METHODS: A prospective, observational study of premature infants (<32 weeks gestation) at discharge during quiet breathing in the supine position. RIP noninvasively measured WOB indices. A high-resolution pulse oximeter collected oxygen saturation and heart rate data. RESULTS: This study included thirty-one infants with BPD and thirty-four infants without BPD. Infants diagnosed with BPD had increased phase angle [BPD Φ = 73 . 90 (8.2) vs NoBPD Φ = 52.6 (8.2), p = 0.039]. Infants diagnosed with BPD had decreased saturations [BPD SpO2 = 96% (0.4) vs NoBPD Sp02 98% (0.3), p=<0.001], increased time with saturations less than 85% [BPD % =2.74 (0.7) vs NoBPD % =0.91 (0.4), p = .018], and increased time with saturations less than 80% [BPD % =1.57 (0.5) vs NoBPD % =0.52 (0.3), p = 0.045]. There was no difference in heart rate or breaths per minute for infants with BPD versus controls. CONCLUSION: Premature infants with BPD demonstrated increased TAA and had lower saturations compared to infants without BPD at discharge despite being chronologically older and being discharged at an older corrected gestational age. The impact of BPD on breathing patterns persists at discharge and suggests these patients may have residual lung and/or respiratory muscle dysfunction.
Visual scale to document acute dizziness in the hospital
Authors: Büki Bela , Irsigler Jaqueline , Jünger Heinz , Harrer Christine , Schubert Michael C. 
Published: July 2024

BACKGROUND: Managing acute vertigo/dizziness for inpatients requires valid communication between the various healthcare professionals that triage such life-threatening presentations, yet there are no current scaling methods for managing such acute vertigo symptoms for inpatients. OBJECTIVE: To describe the development and validation of the Krems Acute Vertigo/Dizziness Scale (KAVEDIS), a new instrument for tracking subjective symptoms (vertigo, dizziness) and gait impairment across four unique vestibular diagnoses (Menière’s disease, benign paroxysmal positional vertigo, peripheral vestibular hypofunction, and vestibular migraine) over a one-year period after inpatient hospital admission. METHODS: Retrospective data collection study from KAVEDIS scale and chart documentation. RESULTS: The KAVEDIS scale can significantly distinguish scores from admission to discharge in three of four vestibular diagnoses. The documented course of subjective vestibular symptoms and gait disturbances were correlated in all four groups. CONCLUSION: We suggest that KAVEDIS documentation among inpatients admitted with acute vertigo/dizziness may improve communication between the various intervening clinicians and help to raise concern in cases of symptomprogression.
Monitoring dan Data Logger Panel Distribusi Dengan Power Meter dan SCADA LabVIEW
Authors: Susilo Joko Tri , Sutarmin Sutarmin 
Published: June 2024

Penggunaan energi listrik dari tahun ke tahun semakin meningkat sesuai dengan kemajuan peradaban manusia. Dengan besarnya penggunaan energi listrik maka perlu dilakukan pengaturan dan pembatasan penggunaan energi listrik. Pengukuran besaran listrik biasanya dilakukan dengan menggunakan alat ukur sederhana dengan pencatatan manual sehingga data yang didapat tidak realtime dan memerlukan proses untuk mendapatkan hasil pengukuran. Pada penelitian ini dibuat monitoring dan data logger panel distribusi dengan mengunakan power meter dan SCADA LabVIEW. Alat tersebut untuk membantu memonitoring besaran listrik pada panel distribusi secara real time. Penelitian ini bertujuan membuat seperangkat sistem monitoring dan data logger panel distribusi dengan mengunakan power meter dan SCADA LabVIEW dan mengetahui nilai besaran listrik pada panel distribusi secara real time. Pembuatan alat monitoring menggunakan Power Meter dan SCADA LabVIEW sebagai sebuah antarmuka, pengolahan data dan juga system data logger. Pada pengujian tegangan sistem ini dapat bekerja dengan baik dengan rata rata error pembacaan tegangan sebesar 0.03%, pada pengujian pembacaan arus sistem ini dapat bekerja dengan baik dari penilaian rata rata error pembacaan sebesar 0.3%, pada pengujian pembacaan daya aktif diperoleh nilai rata rata error sebesar 0.16%, pada pengujian pembacaan daya reaktif diperoleh nilai rata rata error sebesar 2.35%, pada pengujian pembacan frekuensi rata rata error pembacaan sebesar 0.03%, pada pengujian pembacaan nilai kWh antara tampilan LCDpower meter dan LabView rata rata error pembacaan sebesar 0.46% dan didapat rata rata delay yang ada pada pembacaan Power Meter ke LabVIEW sebesar 12 milidetik.
Analisis Thermal Instalasi Capacitor Bank 575 kVar Menggunakan Metode Infrared Thermography
Authors: Setiawan Agus , Suminto Suminto , Solihin Lili 
Published: June 2024

Kegagalan komponen listrik pada industri dapat menyebabkan gangguan proses produksi, bahkan kecelakaan. Infrared thermography merupakan metode yang efektif untuk pemeliharaan prediktif, dengan tujuan mengidentifikasi potensi kerusakan komponen sebelum terjadi kegagalan. Penelitian ini bertujuan untuk menganalisis kondisi instalasi capacitor bank 575 KVAr menggunakan infrared thermography. Standar yang digunakan adalah Standart for Infrared Inspection of Electrical System and Rotating Equipment. Hasil penelitian menunjukan sebagian besar kondisi instalasi capacitor bank 575 kVAr dalam skala prioritas 3 suhu maximum 44,5°C delta T 18,3 yang berarti kondisi perlu dilakukan tindakan korektif dengan izin penjadwalan. Tindakan korektif yang bisa dilakukan adalah memeriksa instalasi kabel, kekencangan skun kabel, kekencangan terminal koneksi pada kontaktor dan MCCB. Satu bagian yang memiliki skala prioritas 4 adalah pada bagian MCCB dan Kontaktor capacitor bank tampak depan bagian bawah dengan nilai hot point 35,1°C memiliki delta T 8,9.
Robust Methods for Assessing the Characteristics of Locomotor Activity Based on Markerless Video Capture Data
Authors: Bogachev M. I. , Grigarevichius K. R. , Pyko N. S. , Pyko S. A. , Tsygankova M. , Plotnikova E. A. , Ageeva T. V. , Mukhamedshina Ya. O. 
Published: July 2024

Introduction. Analysis of locomotor activity is essential in a number of biomedical and pharmacological research designs, as well as environmental monitoring. The movement trajectories of biological objects can be represented by time series exhibiting a complex multicomponent structure and non-stationary dynamics, thus limiting the effectiveness of conventional correlation and spectral time series analysis methods. Recordings obtained using markerless technologies are typically characterized by enhanced noise levels, including both instrumental noise and anomalous errors associated with false estimates of the location of the points of interest, as well as gaps in the trajectories, promoting an urgent need in the development of robust methods to assess the characteristics of locomotor activity.Aim. Development of robust methods for assessing the characteristics of locomotor activity capable of efficient processing of noisy recordings obtained by markerless video-based motion capture systems.Materials and methods. In order to assess the characteristics of locomotor activity, the relative movements of body parts of laboratory animals were analyzed using the stability metrics of the mutual dynamics of their trajectories, their relative delays, as well as the relative duration of the recording fragments when relatively stable mutual dynamics could be observed. The local maxima of the cross-correlation function of two body fragments, the minima of the standard deviation of the difference between their Hilbert phases, as well as their relative delays, were used as the metrics of mutual dynamics.Results. The considered phase metrics were shown to explicitly reflect changes in locomotor activity, while the assessment of time delays using phase metric was shown to be prone to periodic error. The above limitation could be largely overcome using the correlation metrics, assuming that phase and correlation metrics could be combined.Conclusion. The proposed robust methods provide stable estimates of the characteristics of locomotor activity based on markerless video capture recordings, altogether increasing the efficiency of diagnostic procedures and assessment of the therapeutic effect during rehabilitation.
Germination study of seeds of some species of the Zygophyllaceae B.R. family under different environmental and laboratory conditions in Basra Governorate.
Authors: محمد حمزة شذى 
Published: June 2024

This reaserch study germination for three species from Zyophyllaceae family : Fagonia bruguieri (shuika) , Peganumharmala (harmal) , Tribulus terresteris ( kutob) .The experiment condected by repeated three times and emergenc of radicale indication of germination . So two sets of seeds have used in study , one set after ripining season directly and other six month later . First stage planted in natural inviroment by soil bringing from plant, s inviroment in pots in room temperature in three times periods in January , February and April .The result: germination has failed with new ripining seeds but Peganum harmala has small percentge of germination , when the other set of seeds have succeeded germination at same three periods with different percentage among three species . The other experiment conducted in laboratory under physical conditions to breaking dormancy of seeds . The result: three species have different ranges for germination under different inviromental conditions .
The Concept of Death in Kakawin Sumanasantaka
Authors: Windya Ida Made , Sri Marselinawati Putu , Ariasa Giri I Made 
Published: June 2024

One of the human attempts to overcome death through a cultural approach is the Kakawin Sumansantaka composed by Mpu Monaguna. This implies messages implicitly that birth and death are mysteries of life. This research aims to add to the treasure of knowledge about life and death. The type of research used is interpretative qualitative research. The primary data source is the text of Kakawin Sumanasantaka. The data analysis technique uses content analysis to analyse the content of Kakawin Sumanasantaka. From the research results, it is known that the way a person dies is different according to his karma. In Kakawin Sumanasantaka it is mentioned that Dewi Harini's death was due to being cursed by Pandita T??a Windu, her fault for disturbing the Pandita's asceticism. Harini was born as Indumati and then she was killed by the Sumanasa flower which freed her from the human body so that she could return to Indraloka. In contrast, the death of King Aja who threw himself at the right time into the confluence of the Suranadi and Sarayu Rivers as a symbolic meeting of the nadis of Ida and Pinggala at Ajña Cakra. Ajña chakra is one of the ?iwa clans of the path of ?tma out of the body. The Kakawin Sumanasantaka thus presents the correct way o f dying of several characters such as the death of Dewi Harini's way, the death of Dewi Indumati's way and the death of Raja Aja's way.
QUALITY ASSESSMENT AND STABILITY STUDIES OF METRONIDAZOLE TABLETS FORMULATIONS OBTAINED VIA CRYSTALLO CO-AGGLOMERATION TECHNIQUE
Authors: Adullahi Abba Khalid , Olowosulu Adeniji Kehinde , Allagh T. S. 
Published: July 2024

Stability studies are essential for assessing the quality, safety, and efficacy of pharmaceutical products, ensuring they maintain their properties over time. This study aimed to assess the stability of metronidazole tablets stored in a desiccator with charged silica gel following the International council for harmonization of Technical Requirements for Pharmaceuticals for Human Use guidelines. Metronidazole tablets were formulated from metronidazole co-agglomerates using different excipients by direct compression method and stored for 6 and 12 months at 25±2°C/60±5% relative humidity. Quality parameters such as weight variation, diameter, thickness, hardness, friability, content uniformity, and dissolution rate were evaluated at intervals using the United States Pharmacopeia – National Formulary and British Pharmacopeia specifications. The tablets maintained uniformity in weight, diameter, thickness and content over 12 months, meeting pharmacopeial standards. They exhibited high crushing strength, low friability, and consistent disintegration times (<5 min), across formulations and storage durations with no significant changes after storage, indicating stable performance. The sustained high crushing strength, friability ratio (CSFR) and crushing strength, friability, disintegration time (CSFR/Dt) ratios suggested high tablet strength and quality. In-vitro dissolution studies showed release rates of 87.31 – 100.81 %, with a significant decrease at 6 months within pharmacopeial standards but no change at 12 months. Content uniformity was maintained throughout storage. Metronidazole tablets formulated from crystallo co-agglomerates demonstrated good stability and mechanical strength over 12 months of storage. Storage in air-tight containers with desiccants at controlled room temperature (25±2°C) or below their relative humidities is recommended for maintaining tablet quality
Pengaruh Kejelasan Sasaran Anaggaran Dan Pengendalian Internal Terhadap Akuntabilitas Kinerja Kantor Desa (Studi Empiris Desa Lubuk Lingkuk Kecamatan Lubuk Besar)
Authors: Sania Siti Azizah , Nizarudin Abu , Anggita Wenni 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui: (1)pengaruh kejelasan sasaran anggaran terhadap akuntabilitas kinerja kantor desa. (2)Untuk mengetahui pengaruh pengendalian internal terhadap akuntabilitas kinerja kantor desa. Penelitian ini merupakan penelitian kuantitatif, dimana sempel yang dipergunakan 55 responden yakni perangkat desa dengan membagian kuesioner secara langsung kepada perangkat-perangkat desa dengan menggunakan teknik pengumpulan data yang dilakukan secara langsung (tatap muka). Jenis data yang digunakan yaitu data primer dengan menggunakan regresi liniear berganda. Hasil penelitian ini menunjukan hasil uji statistik t pada tabel IV.10 nilai thitung dari variabel kejelasan sasaran anggaran bernilai sebesar 4,423 dengan signifikansi sebesar 0,000. Sementara ttabel pada penelitian dengan df=51 bernilai 2,00758, sehingga thitung > ttabel (4,423 > 2,00758) dan dengan nilai signifikansi dibawah 0,05 maka dapat dinyatakan bahwa hipotesis alternatif pertama (Ha1) di terima.maka dapat disimpulkan bahwa kejelasan sasaran anggaran berpengaruh signifikan terhadap akuntabilitas kinerja kantor desa.
Edukasi Nutrisi Ibu Hamil sebagai Upaya Pencegahan Stunting di Desa Meunasah Manyet Kecamatan Ingin Jaya Aceh Besar
Authors: Martina Martina , Zuhkrina Yuli , Samir Femmi Omdi 
Published: July 2024

ABSTRAK Stunting adalah kondisi gagal tumbuh pada balita yang disebabkan oleh kekurangan gizi kronis. Stunting mulai terjadi ketika janin masih dalam kandungan disebabkan oleh asupan makanan ibu selama kehamilan yang kurang bergizi. Akibatnya, gizi yang didapat anak dalam kandungan tidak mencukupi. Kekurangan gizi akan menghambat pertumbuhan bayi dan bisa terus berlanjut setelah kelahiran. Masa 1000 hari pertama kehidupan merupakan periode emas dalam mengoptimalkan pertumbuhan dengan memastikan nutrisi yang adekuat sebagai upaya pencegahan stunting. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan ibu hamil tentang kebutuhan nutrisi selama hamil sebagai upaya pencegahan stunting. Metode yang digunakan pada pengabdian kepada masyarakat ini yaitu metode ceramah, diskusi dan tanya jawab. Media yang digunakan adalah poster dan aplikasi persentasi dengan microsoft powerpoint. Peserta kegiatan ini adalah seluruh ibu hamil dan kader posyandu yang berjumlah 37 orang. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan ibu hamil tentang nutrisi yang diperlukan selama hamil. Edukasi nutrisi ibu selama kehamilan memberikan dampak positif dalam peningkatan pengetahuan dan pemahaman ibu hamil tentang kebutuhan nutrisi selama kehamilan. Kata kunci: Nutrisi, Ibu Hamil, Stunting ABSTRACT Stunting is a condition of growth failure in toddlers caused by chronic malnutrition. Stunting begins to occur when the fetus is still in the womb due to the mother's food intake during pregnancy which is less nutritious. As a result, the nutrients obtained by children in the womb are insufficient. Malnutrition will inhibit the baby's growth and can continue after birth. The first 1000 days of life is a golden period in optimizing growth by ensuring adequate nutrition as an effort to prevent stunting. This community service activity aims to increase the knowledge of pregnant women about nutritional needs during pregnancy as an effort to prevent stunting. The methods used in this community service are lecture, discussion and question and answer methods. The media used are posters and presentation applications with Microsoft Powerpoint. The participants of this activity were all pregnant women and posyandu cadres totaling 37 people. The results of the activity showed an increase in the knowledge of pregnant women about the nutrients needed during pregnancy. Maternal nutrition education during pregnancy has a positive impact on increasing the knowledge and understanding of pregnant women about nutritional needs during pregnancy. Keywords: Nutrition, Pregnancy, Stunting