bluuebunny/crossref_metadata_2025_split huggingface dataset:
2788 – Large-Scale Mutation Screening of the Putative Autism Susceptibility Gene SCN2A in Schizophrenia
Authors: Woolf R. , Carroll L. , Ibrahim Y. , Owen M. , O’ Donovan M. 
Published: July 2013

Introduction:Recent genetic findings suggest shared genetic risk between autism, epilepsy and schizophrenia. A sodium channel subunit gene, SCN2A, exhibits de novo stop-codon mutations in individuals with autism and a stop-codon mutation in an individual with a seizure disorder. Our recent exome-sequencing study of schizophrenia cases identified a de novo splicesite mutation at SCN2A and further mutations may exist.Objectives:To examine a role for rare, protein damaging mutations at SCN2A in the aetiology of schizophrenia.Aims:We aim to show an excess of coding sequence mutations in schizophrenia cases when compared to controls.Methods:Mutation screening of the coding sequence of SCN2A in 993 Caucasian individuals with DSM-IV schizophrenia. We employed High-Resolution Melt Analysis(LightScanner™), followed by dye- terminator sequencing to confirm allele carriers. We compared our results to an exome-sequencing dataset of 4300 Caucasian individuals (NHLBI Exome Sequencing Project).Results:34 variants were identified; 15 intronic, 13 synonymous and 7 non-synonymous. One of the non-synonymous variants introduces a stop codon at amino acid 169 (169 E>X). No stop-codon variants were identified in the control dataset. Burden analysis did not show an excess of protein damaging changes in the UK dataset when compared to controls.Conclusions:A total of 4 stop-codon mutations have been identified at SCN2A; all in individuals with a neuropsychiatric disorder. Our data do not suggest a general role for protein coding mutations at SCN2A in the pathogenesis of schizophrenia; however there may be a role for very damaging alleles at SCN2A in several neuropsychiatric disorders.
2802 – Deceit and Lie Detection Using Automated Microemotion Analysis
Authors: Ptacek R. 
Published: July 2013

Introduction:Deceit and lie detection has been attracting attention of forensic psychologists and psychiatrists for several decades. Different polygraph and imaging methods are being thoroughly examined, usually without really doubtless results. Paul Ekman proposed an interesting theory on micro emotions that may be a demonstration of uncontrolled part of human behaviour and thus may represent an interesting way to detect lie or deceit. Currently there are available on the market several systems for automatic micro emotions detection. These systems show acceptable level of reliability and thus may be used for research purposes.Objectives and aims:The aim of the study was to analyse if computerized system for micro emotion analysis (Face Reader) can be used for distinguishing liars from non-liars. For that purposes classical experimental double blind setting was established. The group of university students (n = 40) was divided into a subgroup exposed to a video scene and a subgroup not exposed (n = 20). The goal of further analysis was to distinguish there two groups using Face Reader.Results:In our pilot study, we identified 100% truth tellers and 90% of lie tellers.Conclusions:Upon the presented study we may suggest that software analysis of micro emotion represents an interesting way for detecting lie and deceit. Although the current state of knowledge does not allow using this method in forensic setting, the possibilities and limits of the method should be properly examined.
2809 – Clinical Factors Associated with High Dosage of Methadone Among Clients Attending the Methadone Clinic in Hospital Permai, Malaysia
Authors: Zakaria H. , Mohd Yusof S.A. , Midin M. , Abu Bakar A.K. , Md Yusof H. , Abdullah M.N. 
Published: July 2013

Introduction:One of the most researched factors which contribute to the good outcome of methadone therapy is the dosage, but local studies which look into the factors associated with the dosage of methadone itself is lacking.Objective:To compare clinical factors including level of motivation and the quality of life among the active male clients on high and low methadone dosage.Aim:To determine the factors associated with high dosage of methadone in order to improve the services provided.Methods:A cross sectional study of active male methadone clients who are on maintenance treatment attending the Methadone Clinic. It was conducted from early January to the end of March 2010. The questionnaires used include Mini International Neuropsychiatric Interview (MINI), Circumstances, Motivation and Readiness to Change (CMR) and WHO-Quality of Life (WHOQOL-BREF).Results:Those on higher dosages were noted to have significantly better urinalysis results and had a higher CMR score, but quality of life did not differ between the two groups. Motivational level remained significant after regression analysis was done.Conclusions:This study also confirms previous findings of higher methadone dosage having better outcomes in terms of urinalysis results. As the high dose group were also found to be more motivated to change, the regular formal counselling sessions or motivational enhancement therapy was advocated to improve the services of methadone maintenance therapy.
2813 – Clinical Development of Comorbidity in Schizophrenia with Sustained Hypertension. State Institution “crimean State Medical University Named After S. Georgievsky” Simferopol, Ukraine
Authors: Verbenko V. , Yurieva N. 
Published: July 2013

Comorbidity of psychic diseases with different somatic pathology is an essential causes for marking the pattern of the illness worse. Psychiatry stigma causes difficulty in getting adequate treatment of somatic pathology in schizophrenia patients.The goal of the research:The studying of particularities in clinical development of comorbidity in schizophrenia with sustained hypertension.Data and methods:60 patients with paranoid form of schizophrenia accompanied with somatic pathology (sustained hypertension).Use:Clinical-catamnesis, clinical- psychopathology methods, psychometry scale (PANSS, HARS, HDRS, ESRS).Results:Clinical features of comorbidity in schizophrenia with sustained hypertension are characterized by structural particularities of productive and deficiency disorders. The depression with hypochondriasis and anxiety symptoms is more expressive. Neurocognitive symptoms and low quality remission are marked (p < 0,01). Male patients more often have negative symptoms of anxiety (46,7%),irritability and aggressive behavior (33,3%)were marked in comparison with the control group (p < 0,05). Were identified patients could endure psychic medications worse. Resistance and intolerance to psychotropic medicines were revealed. More corrector medicines in side effect of extrpyramid symptoms were given (p < 0,01) total polyfarmacy (p < 0,01) in patients with comorbidity in schizophrenia and sustained hypertension was marked.Conclusions:Patients with comorbidity in schizophrenia and sustained hypertension developed more complex pattern of the disease. Patients were revealed to endure psychic medications worse. They were marked to have secondary resistance to psychotropic therapy.
2820 – Saliva Testosterone and Male Depressive Syndrome in a Community Study. The Sudurnesjamenn Study
Authors: Sigurdsson B. , Palsson S.P. , Aevarsson O. , Olafsdottir M. , Johannsson M. 
Published: July 2013

Introduction:The relationship between testosterone levels and depressive symptoms has been described as U-shaped in some previous studies.Aims:To investigate the relationship between testosterone levels and male mental health as well as evening cortisol.Methods:In this community study 534 males were screened, using the Beck Depression Inventory (BDI), Gotland Male Depression Scale (GMDS), Montgomery-Åsberg Depression Rating Scale (MADRS) and a general health questionnaire. Those with signs of depression (n = 65) and randomly selected controls (n = 69) were evaluated by a psychiatrist for Depressive Disorder (DD). in a sub-sample (n = 51) saliva testosterone was measured two times on a single day.Results:Morning values were significantly higher than evening values (236 vs. 145 pg/ml p = 0.009). Evening testosterone was significantly higher in males depressive according to both MADRS (p = 0.017) and BDI (p = 0.031). This relationship was also present when tested for U shaped connection by dividing the group into three even parts by testosterone levels. Men with depression were significantly more likely to be in the highest third of testosterone levels (BDI p = 0.021; MADRS p = 0.018). There was also a significant correlation between elevated evening cortisol and evening testosterone levels (p = 0.021). However, high evening cortisol and high evening testosterone were not detecting the same depressive cases according to either BDI or MADRS scales. Thus, simultaneous testing for evening cortisol and evening testosterone did not increase specificity for clinical diagnosis of DD.Conclusion:Males with high evening testosterone seem to be more likely to have depressive symptoms but further studies are needed.
2824 – Acute Psychosis and Buprenorphine Withdrawal: Abrupt vs. Progressive Could make a Difference
Authors: Weibel S. , Mallaret M. , Bennouna-Greene M. , Bertschy G. 
Published: July 2013

Buprenorphine, a partial μ-opioid agonist and κ-opioid antagonist, is frequently used in the treatment of heroin dependence, and to prevent complications arising from intravenous injection and social consequences of heroin use. Psychosis occurring after discontinuation of buprenorphine or other opioids has been described, but is uncommon.We report the case of a 37-year-old man, suffering from opiates dependence, presenting acute and intense psychotic symptoms beginning after an abrupt discontinuation of buprenorphine, which he was taking for two years as substitution therapy for heroin dependence. The initial medication by risperidone, up to a dose of 8 mg/day was inefficient to control psychotic symptoms. Four weeks later, buprenorphine was finally restarted at 8 mg/day, which allowed a complete remission of psychotic and anxiety-related symptoms. The antipsychotic medication was gradually discontinued two months later, allowing the patient to remain symptom-free eighteen months later.We discuss the potential role of abrupt withdrawal syndrome in the apparition of the psychotic symptoms and the presence of a latent psychotic disorder. An interesting issue in our case report is that a correctly conducted antipsychotic treatment did not succeed in stopping symptoms of delusions, even after four weeks, while reintroducing buprenorphine did, showing in this context an antipsychotic effect. This case report highlights the importance of taking opiate dependence into account in patients with recent onset of psychotic symptoms, even several weeks after withdrawal.
2826 – Referral of Heroin Addicts from Syringe Exchange to Evidence-Based Treatment - A Randomized Controlled Trial
Authors: Bråbäck M. , Isendahl P. , Nilsson S. , Hakansson A. 
Published: July 2013

Introduction:Syringe exchange has been suggested as a potential conduit to treatment for drug addiction. This has been tried in a few US trials, but never in Europe.Aims:This study aims to assess effectiveness of a syringe exchange for referral of heroin addicts to evidence-based treatment, and to assess, in an RCT design, the contribution of a case management intervention.Methods:Consecutive heroin addicts attending the syringe exchange of Malmö, Sweden, who are willing to participate, are referred to maintenance treatment (methadone or buprenorphine, medication based on clinical assessment and outside the study design), and randomized to either a strength-based case management intervention in order to facilitate referral, or referral-only. If eligible for treatment, patients are initiated on the maintenance treatment after 12 days. Study outcome is successful transfer from syringe exchange to treatment initiation.Results:The study is currently being finalized, and final results (N = 70–75) will be available before presentation at the EPA congress. Pilot data from the first phase of recruitment revealed that among 21 patients, 16 (76%) were willing to join the study. Among them, all 16 successfully showed up for medical assessment, and all but one (94%) successfully initiated medication. Preliminary follow-up until today confirm a similar picture.Conclusions:Pilot data indicate that syringe exchange can be used for transfer to evidence-based treatment in heroin addiction. High rates of patients are successfully transferred to treatment, with or without a facilitating case management intervention. Final results will be presented at the congress.
2830 – Illness Representation in Patients with Sleep Apnea Syndrome
Authors: Gassara I. , Ben Thabet J. , Msaad S. , Ammar Y. , Zouari N. , Zouari L. , Ayoub A. , Maalej M. 
Published: July 2013

Introduction:Sleep apnea (SA) is a common chronic disease that leads to higher morbidity and mortality; however, illness perceptions (IP) in patients with SA remain not well explored.Objectives:We aimed to assess the IP in patients with SA and to correlate them with the level of sleepness, the severity of the disease and the existence of a concomitant depression.Methods:Sixty four untreated patients investigated for sleep apnea (mean age: 54 years, sex ratio = 2/3) participated in our study.Excessive daytime sleepness (EDS) was assessed by the ESS, the severity of the disease by the apnea/hypopnea index (AHI) and the depressive symptoms by the HADs. Illness representation was measured by the Brief Illness Perceptions Questionnaire (B-IPQ); High scores reveal a more threatening perception of the illness.Results:In terms of cognition, our patients feel quite bothered by their symptoms (7/10) and enable to control their illness (1.3/10), but they believe that their treatment will be effective (7/10). Emotionnally, they feel pretty concerned (6/10) and negatively affected by their disease (6.1/10).We also observed that the score of the B-IPQ (6/10 ± 1.5) was positively correlated to EDS (p = 0.004), the severity of the disease (p = 0.02) and the coexistence of a depression (p = 0.005).Conclusion:Several factors seem to have an impact on the vision of the sleep-apnea's patients towards their disease and their life as well. The study of the IP seems interesting to better understand the coping behaviour of such patients so that their adherence to the treatment would be improved.
2834 – Comparison of Clinical and The Sociodemographic Characteristics of Bipolar Patients According to the Presence of a History of Depressive Episode
Authors: Erdem M. , Akarsu S. , Ünlü A.G. , Alper M. , Karaman D. , Ak M. 
Published: July 2013

Introduction:The aim of this study was to compare the sociodemographic and clinic characteristics of patients with bipolar disorder type I with and without history of depressive episode.Method:In this study the data of 108 bipolar type I patients who were admitted to psychiatry clinic of a university hospital due to manic episode between 2007–2009 were examined.Results:According to these data, 16 of 108 bipolar disorder type I patients (14.8%) had inhabited at least 4 manic episodes throughout their lives and there was no history of depressive episode although the disease had continued at least 4 years. with and without a history of depressive episode of bipolar type I patients have not been identified differ in terms of sociodemographic and clinical characteristics, but patients not having a history of depressive episode during their lifetime was found to be more than the number of hospitalizations.Conclusion:Current information seem to be not sufficient to define unipolar mania as a separate nosological class. Largescale, prospective designs and illuminating the pathophysiology and etiology studies needs to be done in this issue.
2859 – Depression and Diabetes Comorbidity: Prevalence and Clinical Features
Authors: El-Hechmi S. , Zgueb Y. , Jomli R. , Ouanes S. , Nacef F. , Turki Z. 
Published: July 2013

Diabetes is one of the major health problems in the world. The World Health Organization (WHO) predicts that if current trends continue, the number of people with diabetes will double from 176 to 370 million people by 2030.Many studies have demonstrated that a comorbid state of depression incrementally worsens health compared with depression alone.In Tunisia, according to the survey of mental health in the general population, in 2005, the prevalence of depression was 35%.Objective:The aim of our study was to determine the prevalence of depression in diabetic patients who consulted the Tunisian National Institute of Nutrition and to assess risk factors and clinical features of these disorders.Methodology:Cross-sectional study including a population of 100 diabetic patients. A form was designed for epidemiological data collection. Depression was measured using the Hamilton Depression Rating Scale (HAMD).Results:Our results showed a high prevalence of depression in diabetic subjects. 51% of diabetic patients have moderate to severe depression, 13% had mild depression, while 36% had normal values on the HAM-D. Moderate to severe depression was present in 37% of men and 42% women.Conclusion:Diabetes is associated with a significantly increased risk for depressive symptoms. Our study confirms the usefulness of the assessment of depressive symptoms during follow-up of diabetic patients and the importance of an early multidisciplinary care. Pathogenetic mechanisms connecting diabetes with depression deserve further exploration.
2868 – Comorbid Psychiatric Disorder and Physical Disorder in the Elderly
Authors: Ennaoui R. , Jomli R. , Zgueb Y. , Nacef F. 
Published: July 2013

Introduction:With aging, the risk of many diseases increases. The prevalence of somatic diseases in psychiatric patients is high. This comorbidity is more common that the subject is old.Objectives:The aim of our study was to determine the different somatic pathologies associated with various psychiatric disorders in the elderly.Patients and methods:This is a retrospective study conducted in the outpatient hospital razi, involving 90 patients aged consultant during 2011. The data were collected from patient records.Results:Ninety patients were found during the study period. The average age of patients was 77.5 years. The sex ratio (M / F) was 1.04. The majority of consultants had an iron status of married (51.1%) and widowed (41.1%). 63% of patients were retired and 49% of cases were low socioeconomic level. Personal psychiatric histories were found in 12% of patients consultants. 51 patients (56.6%) had somatic pathology associated with psychiatric disorders.Conclusions:Elderly patients' organic disease is unknown in most cases and is a causal or aggravating the mental disorder.
2873 – Drug Overdosing, Personality Disorder and Self-Injurious Behaviour
Authors: de la Vega D.C. , Arcenegui Calvo A. 
Published: July 2013

Introduction:Suicide and self-injurious behaviour are one of the most common causes of consulting in the hospital emergency services. Most of the cases, are attempts made by intake of great quantities of drugs (drug overdosing).Objectives:Review of the drug overdosings attended in our Hospital emphasizing our interest in the presence of psychiatric history, characteristics of the attempt and case management.Methods:Retrospective review of clinical histories of patients attended by the Emergency Service.Results:We identified 112 drug overdosings.68'8% of the patients attended were women, being the most frequent age range from 31 to 40 years (33%).80'4% of the patients collected had psychiatric history, being the most common diagnosis: Mood-Anxiety disorders 60'7%, Substance-Related Disorders 41'1%, Personality disorder 30'4% and Psychotic disorder 10'7.Previous attempts were found in 43'8% of the patients.The most common drug used were benzodiacepines (73% of the cases), followed by antypsichotics (17'9%). Up to 32'1% of the patients used non psychitrict drugs.The most common diagnosis was suicide attempt (41'1%), followed by parasuicide attempt. 41'4% of the drug overdosings were not considered as self injurious behavior.When we compared those diagnosed of personality disorder with the rest of the patients, we found that although they were more often diagnosed of parasuicide (50% Vs 32'1%), they needed more hospitalizations (41% Vs 21%)Conclusions:Self-injurious behaviour are one of the most common causes of consulting in the hospital emergency services. Patients diagnosed of personality disorder are more commonly hospitalized after making a suicide attempt.
2937 – Emotion Regulation in ADHD Children in Face©-Perspective: From Theory Through Research to Facilitating Adjustment of Cognition and Emotion
Authors: Celestin-Westreich S. , Celestin L.-P. 
Published: July 2013

Background:Clinical and neuroscientific insights suggest that emotion regulation (ER) is a core challenge for children with Attention Deficit Hyperactivity Disorder (ADHD). Relatively few empirical studies yet explicitly address ADHD children's ER. The conceptual and practical underpinnings of ER for ADHD youth's wellbeing also remain to be fully established. Objectives and aims: To assess basic and contextual emotion recognition in children with ADHD. To advance conceptual and practical insights into ADHD children's emotional development.Method:Operationalising the FACE©-model (Facilitating Adjustment of Cognition and Emotion), an ongoing research compares children with ADHD and matched non-referred controls (currently n = 68, ages 7–12, mean age 10, 80% boys) on ER components, including facial (FER) and verbal emotion recognition, Theory-Of-Mind, attentional, and behavioural functioning.Results:A subsample of ADHD children (n = 15) with comorbid learning problems and autism spectrum symptoms (ASS) made significantly more FER errors (t (26) = -2,578, p = 0,016), especially for happiness and anger, and doubted more their choices (t (26) = -2,147, p = 0,041). Another subsample of learning disordered ADHD children without ASS (n = 20) did not differ in basic FER compared to controls (n = 20) but was less efficient in contextualising emotions, especially anxiety, and in Theory of Mind. ADHD children's behavioural problems were inversely proportional to their emotion recognition skills.Conclusions:Children with ADHD as a group appear differentially inclined to experience emotion processing difficulties compared to peers. Fine-grained FACE© risk-resiliency mapping helps identifying individual ADHD children in need of training in emotional adjustments to routine contextual demands.