bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treasury auction method and underpricing: Evidence from Iceland
Authors: Noel Antoine , Wu Mark 
Published: August 2024

AbstractThe Central Bank of Iceland replaced the discriminatory method used for auctioning treasury securities with the uniform‐price method in 2009. We analyze underpricing before and after this institutional reform with a sample of 516 auctions organized from 2000 to 2018. After controlling for auction characteristics and financial market conditions, we find that underpricing is lower under the uniform‐price method. However, this underpricing decline does not translate into a reduction in sovereign issuance cost. The emergence of overpricing, observed in the late part of our sample, coincides with the growing importance of commissions paid to primary dealers. Our results provide practical implications for governments, regulators, and market participants.
The pineapple reference genome: Telomere‐to‐telomere assembly, manually curated annotation, and comparative analysis
Authors: Feng Junting , Zhang Wei , Chen Chengjie , Liang Yinlong , Li Tangxiu , Wu Ya , Liu Hui , Wu Jing , Lin Wenqiu , Li Jiawei , He Yehua , He Junhu , Luan Aiping 
Published: August 2024

ABSTRACTPineapple is the third most crucial tropical fruit worldwide and available in five varieties. Genomes of different pineapple varieties have been released to date; however, none of them are complete, with all exhibiting substantial gaps and representing only two of the five pineapple varieties. This significantly hinders the advancement of pineapple breeding efforts. In this study, we sequenced the genomes of three varieties: a wild pineapple variety, a fiber pineapple variety, and a globally cultivated edible pineapple variety. We constructed the first gap‐free reference genome (Ref) for pineapple. By consolidating multiple sources of evidence and manually revising each gene structure annotation, we identified 26,656 protein‐coding genes. The BUSCO evaluation indicated a completeness of 99.2%, demonstrating the high quality of the gene structure annotations in this genome. Utilizing these resources, we identified 7,209 structural variations across the three varieties. Approximately 30.8% of pineapple genes were located within ±5 kb of structural variations, including 30 genes associated with anthocyanin synthesis. Further analysis and functional experiments demonstrated that the high expression of AcMYB528 aligns with the accumulation of anthocyanins in the leaves, both of which may be affected by a 1.9‐kb insertion fragment. In addition, we developed the Ananas Genome Database, which offers data browsing, retrieval, analysis, and download functions. The construction of this database addresses the lack of pineapple genome resource databases. In summary, we acquired a seamless pineapple reference genome with high‐quality gene structure annotations, providing a solid foundation for pineapple genomics and a valuable reference for pineapple breeding.
Proteomic dynamics revealed sex‐biased responses to combined heat‐drought stress in Marchantia
Authors: Guerrero Sara , Roces Víctor , García‐Campa Lara , Valledor Luis , Meijón Mónica 
Published: August 2024

ABSTRACTRecent studies have documented plant responses to climate change extensively, particularly to single‐stress exposures. However, critical factors for stress survival, such as sexual differentiation, are not often considered. The dioicous Marchantia polymorpha stands as an evolutionary milestone, potentially preserving ancestral traits from the early colonizers. In this study, we employed proteomic analyses complemented with physiological monitoring to investigate combined heat and drought responses in Tak‐1 (male) and Tak‐2 (female) accessions of this liverwort. Additionally, targeted transcriptomics was conducted using different natural populations from contrasting environments. Our findings revealed sex‐biased dynamics among natural accessions, particularly evident under control conditions and during early stress responses. Although Tak‐2 exhibited greater diversity than Tak‐1 under control conditions, male accession demonstrated distinct and more rapid stress sensing and signaling. These differences in stress response appeared to be strongly related to sex‐specific plasticity influenced by geoclimatic origin. Furthermore, we established distinct protein gene ages and genomic distribution trends, underscoring the importance of protein diversification over time. This study provides an evolutionary perspective on sexual divergence and stress emergence employing a systems biology approach, which allowed for the establishment of global and sex‐specific interaction networks in the stress response.
The combination of a microbial and a non‐microbial biostimulant increases yield in lettuce (Lactuca sativa) under salt stress conditions by up‐regulating cytokinin biosynthesis
Authors: Benito Patricia , Celdrán Marina , Bellón Javier , Arbona Vicente , González‐Guzmán Miguel , Porcel Rosa , Yenush Lynne , Mulet José M. 
Published: August 2024

ABSTRACTSalinization poses a significant challenge in agriculture, exacerbated by anthropogenic global warming. Biostimulants, derived from living microorganisms or natural extracts, have emerged as valuable tools for conventional and organic agriculture. However, our understanding of the molecular mechanisms underlying the effects of biostimulants is very limited, especially in crops under real cultivation conditions. In this study, we adopted an integrative approach to investigate the effectiveness of the combined application of plant growth‐promoting bacterium (Bacillus megaterium strain BM08) and a non‐microbial biostimulant under control conditions (normal watering) and salt stress. After confirming the yield increase under both conditions, we investigated the molecular mechanisms underlying the observed effect by measuring a number of physiological parameters (i.e., lipid peroxidation, antioxidants, chlorophylls, total phenolics and phytohormone content), as well as RNA sequencing and primary metabolite analyses. Our findings reveal that the combined effect of the microbial and non‐microbial biostimulants led to a decrease in the antioxidant response and an up‐regulation of genes involved in cytokinin biosynthesis under salt stress conditions. This, in turn, resulted in a higher concentration of the bioactive cytokinin, isopentenyladenosine, in roots and leaves and an increase in γ‐aminobutyric acid, a non‐proteic amino acid related to abiotic stress responses. In addition, we observed a decrease in malic acid, along with an abscisic acid (ABA)‐independent up‐regulation of SR‐kinases, a family of protein kinases associated with abiotic stress responses. Furthermore, we observed that the single application of the non‐microbial biostimulant triggers an ABA‐dependent response under salt stress; however, when combined with the microbial biostimulant, it potentiated the mechanisms triggered by the BM08 bacterial strain. This comprehensive investigation shows that the combination of two biostimulants is able to elicit a cytokinin‐dependent response that may explain the observed yield increase under salt stress conditions.
Coordination of miR319–TaPCF8 with TaSPL14 orchestrates auxin signaling and biosynthesis to regulate plant height in common wheat
Authors: Hao Pingan , Jian Chao , Hao Chenyang , Liu Shujuan , Hou Jian , Liu Hongxia , Liu Haixia , Zhang Xueyong , Zhao Huixian , Li Tian 
Published: August 2024

ABSTRACTWheat culms, comprising four to six internodes, are critically involved in determining plant height and lodging resistance, essential factors for field performance and regional adaptability. This study revealed the regulatory function of miR319 in common wheat plant height. Repression of tae‐miR319 through short tandem target mimics (STTM) caused an increased plant height, while overexpression (OE) of tae‐miR319 had the opposite effect. Overexpressing a miR319‐resistant target gene TaPCF8 (rTaPCF8), increased plant height. TaPCF8 acted as a transcription repressor of downstream genes TaIAAs, which interact physically with TaSPL14. The significant differences of indole‐3‐acetic acid (IAA) contents indicate the involvement of auxin pathway in miR319‐mediated plant height regulation. Finally, we identified two TaPCF8 haplotypes in global wheat collections. TaPCF8‐5A‐Hap2, as per association and evolution examinations, was subjected to strong substantial selection throughout wheat breeding. This haplotype, associated with shorter plant height, aligns with global breeding requirements. Consequently, in high‐yield wheat breeding, we proposed a potential molecular marker for marker‐assisted selection (MAS). Our findings offer fresh perspectives into the molecular mechanisms that underlie the miR319–TaPCF8 module's regulation of plant height by orchestrating auxin signaling and biosynthesis in wheat.
A comprehensive investigation of biochemical status in patients with telogen effluvium: Analysis of Hb, ferritin, vitamin B12, vitamin D, thyroid function tests, zinc, copper, biotin, and selenium levels
Authors: Durusu Turkoglu Irem Nur , Turkoglu Aziz Kaan , Soylu Seçil , Gencer Gülcan , Duman Rümeysa 
Published: August 2024

AbstractAimThe etiology of telogen effluvium (TE) includes situations that may cause physiological stress, surgical trauma, inflammatory, infectious, iatrogenic causes, medications and nutritional deficiencies. TE has been associated with iron deficiency, vitamin B12 deficiency and thyroid diseases. In recent years, the use of over‐the‐counter food supplements containing vitamins and minerals such as biotin, vitamin D, zinc (Zn), copper (Cu) and selenium (Se) has been increasing in TE patients. The aim of this study is to investigate whether there are differences in nutritional status, vitamin and mineral levels by comparing individuals with TE and a control group.Materials and MethodsThis case–control study included 90 female patients diagnosed with chronic telogen effluvium (CTE), and 90 female controls volunteered to participate in the study who consulted for reasons other than TE. Both groups aged 18 and over and applied to dermatology polyclinic between 01.09.2022 and 01.09.2023. A detailed anamnesis was taken from all patients, a hair pull test was performed, and TE was diagnosed after a dermoscopic examination was performed on all areas of the scalp. Then, serum vitamin D, Zn, Cu, Se levels and biotin levels in serum and urine were measured. Hemoglobin (Hb), ferritin, vitamin B12 and thyroid function tests were retrospectively scanned from the hospital database.ResultsIt was determined that Zn levels were significantly lower in CTE patients than in controls. Se levels were found to be significantly higher in patients than in controls. There was no difference in Hb, ferritin, vitamin B12, thyroid function tests, vitamin D, Cu levels, serum and urine biotin levels between the two groups. Zn, Cu/Zn and Se levels were found to have statistically significant diagnostic performance in predicting the diagnosis of CTE. Cu/Zn ratio and Se value were found to be significant predictors of CTE.ConclusionThis study shows us that nutritional deficiencies are not as common as thought in patients diagnosed with TE. Other causes that may cause TE should be investigated by a detailed anamnesis and a good physical examination. After all, tests for suspected conditions should be performed and individualized treatment options should be created for each patient.
Clinical and demographic moderators of self‐care and hospitalizations in pre‐coronary artery bypass grafting patients: A cross‐sectional study
Authors: Koson Naruebeth , Srisuk Nittaya , Juntratip Nipaporn , Borvornsudhasin Piyatida , Thompson David R. , Ski Chantal F. 
Published: August 2024

AbstractAimTo examine the influence of clinical and demographic factors on self‐care behaviour and hospitalization rates among patients with coronary heart disease awaiting coronary artery bypass grafting.BackgroundAppropriate self‐care behaviour can improve the management of patients with coronary heart disease and reduce hospitalization rates among those awaiting coronary artery bypass graft surgery. However, little is known about the influence of clinical and demographic factors on self‐care or hospitalizations in this population.DesignA cross‐sectional study.MethodsA convenience sample of 99 participants diagnosed with coronary heart disease awaiting coronary artery bypass grafting surgery were recruited from an outpatient clinic of a public tertiary hospital in southern Thailand. Data were collected on clinical (left ventricular ejection fraction, symptom severity and comorbid disease) and demographic (age, education level and marital status) factors, self‐care behaviour and hospitalization rates. Path analysis using LISREL was performed to examine the influence of self‐care on hospitalizations, with clinical and demographic factors as moderators.ResultsPath analysis showed that clinical and demographic factors accounted for nearly half of the variance (46%) in self‐care, and that self‐care accounted for nearly half of the variance (48%) in hospitalization rates.ConclusionOur findings demonstrate that clinical and demographic factors play an important role in self‐care behaviour, and in turn hospitalization rates of pre‐coronary artery bypass graft surgery patients. It is suggested that the period pre‐surgery is an ideal time to introduce programmes designed to bolster self‐care and minimize uncertainty among this patient population and that nurses are well‐positioned to do so.Reporting MethodStudy methods and results reported in adherence to the STROBE checklist.Patient or Public ContributionPatients contributed their consent, time and data to the study.
Why a Little Diversity doesn't Go a Long Way: A Collective Moral Licensing Explanation for Homosocial Reproduction
Authors: Ellen B. Parker , Sexton Jennifer C. , Watkins Marla Baskerville 
Published: August 2024

AbstractDespite significant knowledge on the demographic composition of workgroups, the literature lacks group‐level theory that addresses the tendency of work groups with token levels of diversity to maintain their demographic imbalance over time. We explain this phenomenon by extending moral licensing theory to the group level, arguing that a token level of racial or gender diversity leads to the development of a collective moral credential. This credential provides psychological permission for groups to relax their moral strivings, such that they are less likely to question the influence of bias in group member selection decisions, and thus more likely to make subsequent homogenous group member additions. Additionally, we argue that the diversity climates within which groups are embedded can either magnify (i.e., in fairness‐focused diversity climates) or mitigate (i.e., in synergy‐focused diversity climates) the development of a collective moral credential. Further, we suggest that the effect of token levels of diversity on the development of a collective moral credential can be affected by the prevailing social norms for diversity. Finally, we theorize that the effects of this process can be accentuated by group use of a majority decision rule and attenuated by group use of a unanimous decision rule.
Navigating challenges and shaping futures through mental health nursing in the United Kingdom
Authors: McShane Dean , Madden Amy , Kinsey Lucy , Bifarin Oladayo 
Published: August 2024

Accessible SummaryWhat is known on the subject?

Mental health nurses in the UK play a critical role in providing care, advocating for patients and navigating the complexities associated with mental health challenges.

Acknowledging and supporting the efforts of mental health nurses is essential for advancing mental health care, promoting inclusivity and fostering community resilience amidst ongoing challenges within existing health care organisations.

What this paper adds to existing knowledge?

Highlights the integral role of mental health nurses in the UK's health system as both care providers and advocates, underpinning the importance of addressing the growing demand for mental health services

Introduces innovative digital tools like the ‘Hub of Hope’ and the potential of social prescribing as effective strategies for improving access to mental health care and support.

Emphasises the need for enhanced support and recognition of mental health nurses to ensure the sustainable advancement of mental health services and the well‐being of communities.

What are the implications for practice?

Mental health nurses should integrate innovative digital tools like the ‘Hub of Hope’ into their practice to improve signposting and access to mental health resources for individuals in need.

There is a critical need for ongoing education and support for mental health nurses within practice settings to maintain their well‐being and enhance their ability to provide holistic care despite increasing clinical demands.

Advocacy for increased investment in mental health resources and support for research activities lead by mental health nurses is essential to address current service gaps and promote the development of more effective interventions.
What is the Most Helpful Body‐Scan Posture for People with Attention‐Deficit/Hyperactivity Disorder Tendency?
Authors: Fukuichi Ayano , Wakita Takafumi , Sugamura Genji 
Published: August 2024

AbstractWe explored body‐scan postures suitable for people with attention‐deficit/hyperactivity disorder (ADHD) tendency by developing and validating the Mindfulness Encouraging/Discouraging Reactions Scales (MERS/MDRS), using university students. In Study 1, we conducted a survey to collect typical positive and negative reactions during mindfulness exercises from 21 participants and created the preliminary items. In Study 2, 192 participants completed existing state/trait mindfulness scales and the preliminary MERS and MDRS after mindful breathing. Based on an item response model, we developed and validated MERS and MDRS. In Study 3, 19 participants were categorized into one of four groups: (a) combined, (b) hyperactive/impulsive, (c) inattentive, and (d) without ADHD tendencies. They performed body‐scan meditations with each of the counterbalanced postures (upright, slumped, leaning‐back sitting, and supine), and completed the questionnaires. The analysis showed that those with hyperactivity/impulsivity tendency found the body‐scan meditation a challenge with the slumped posture and easier to perform in the supine posture; the upright posture provided high and low MERS to the hyperactivity/impulsivity tendency group and combined group, respectively; and sleepiness correlated with MERS in the supine posture (r = .49) and the upright posture (r = .51). We identified helpful body scan postures for people with ADHD tendency, using MERS and MDRS, but it was noted that these scales were created solely based on intuitive impressions for beginners, and it is not recommended that the items included in them be aimed for or avoided.
The Origin of the Dominant: Schoenberg's ‘Strong Progression’ and the Realisation of Implied Virtual Pitches
Authors: PARNCUTT RICHARD 
Published: August 2024

ABSTRACTIn major‐minor tonality, V implies I, and rising fourths, falling thirds and rising seconds between successive chord roots are more common than falling fourths, rising thirds and falling seconds respectively. Possible explanations involve history (in two‐part medieval counterpoint, harmonic major sixths resolved to octaves – maintained in V–I); the rising leading note (V–I includes it, IV–I does not); acoustic speculation (in V–I, the third harmonic of resolves to the second); voice leading (in V7–I, a tritone resolves to a third by contrary step); melodic closure (a rising melodic leap implies subsequent falling steps, and melodies often end with –, harmonised V–I); root newness (chords ‘progress’ if the second chord's root is not part of the first); and tonal stability (V is less stable than IV, giving it a stronger ‘urge’ to resolve). An additional possibility combines the ‘virtual‐pitch’ theory of Ernst Terhardt with the ‘implication‐realisation’ theory of Leonard B. Meyer and Eugene Narmour. Major and minor triads imply subsidiary virtual pitches (missing fundamentals; see Rameau's ‘fundamental bass’) at third and fifth intervals below the root. These weakly perceived pitches are realised in the next chord if the root falls by a third or rises a fourth or major second, creating a feeling of forward progression – while also facilitating intonation for singers and melodic instrumentalists. The theory correctly predicts that successive harmonic complex (but not pure) tones an octave apart sound more similar if rising, and rising octaves are more common than falling in melody. It also explains why Classical modulations are asymmetrical in the opposite direction, major keys tending to modulate to V (not IV) and minor to III (not VI): accidental flats tend to be more perceptually salient or stable than sharps.
The Aspergillus galactomannan Ag VIRCLIA® Monotest and the sõna Aspergillus galactomannan lateral flow assay show comparable performance for the diagnosis of invasive aspergillosis
Authors: Küpper Corinna , Erb Timothy Moritz , Träger Johannes , Meintker Lisa , Valenza Giuseppe , Bogdan Christian , Held Jürgen 
Published: August 2024

AbstractBackgroundRapid galactomannan tests, such as the sõna Aspergillus GM Lateral Flow Assay (GM‐LFA) and the Aspergillus Galactomannan Ag VIRCLIA® Monotest (GM‐Monotest), which are suitable for the analysis of single samples, have the potential to accelerate diagnosis of invasive aspergillosis (IA).ObjectivesTo compare the performance of the GM‐Monotest and the GM‐LFA for the diagnosis of IA.Patients/MethodsTwo patient cohorts were analysed: adults who had received an allogeneic haematopoietic stem‐cell transplant (alloHSCT‐cohort) and patients with proven/probable IA from a 5‐year period (cross‐sectional IA‐cohort). In the alloHSCT‐cohort, weekly serum samples were tested, whereas in the cross‐sectional IA‐cohort sera and bronchoalveolar lavage fluids were analysed. The diagnostic performance was calculated using two definitions for positivity: (1) a single positive GM result and (2) at least two positive GM results from consecutive samples. IA classification followed EORTC/MSG 2019.ResultsThe alloHSCT‐cohort included 101 patients. Four had proven/probable IA, 26 possible IA and 71 no IA. The specificity for one positive serum and two consecutively positive sera was 88.7% and 100% (GM‐Monotest) and 85.9% and 98.6% (GM‐LFA). Comparison of ROC curves in the alloHSCT‐cohort showed no significant difference. The cross‐sectional IA‐cohort included 59 patients with proven/probable IA. The sensitivity for one positive sample and two consecutively positive samples was 83.1% and 55.1% (GM‐Monotest) and 86.4% and 71.4% (GM‐LFA).ConclusionsBoth assays showed comparable diagnostic performance with a higher sensitivity for the GM‐LFA if two consecutive positive samples were required for positivity. However, due to poor reproducibility, positive GM‐LFA results should always be confirmed.