bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of codeine-containing medicines by Irish psychiatric inpatients before and after regulatory limitations on their supply
Authors: Agyapong V. I. O. , Singh K. , Savage M. , Thekiso T. B. , Finn M. , Farren C. K. , McLoughlin D. M. 
Published: March 2013

BackgroundIn recent years, concerns have been highlighted in several jurisdictions, including Ireland, regarding abuse of over-the-counter codeine-containing medicines. On the 1st of August 2010, national regulatory guidelines aimed at limiting the supply of these medicines in Ireland came into force.AimsTo study the effects of the new regulations on the use of non-prescribed codeine-containing medicines by psychiatric patients admitted to an Irish university teaching hospital before (n= 117) the regulations came into effect and 6 months afterwards (n= 126).MethodsParticipants completed a brief self-administered survey questionnaire about their use of over-the-counter codeine-containing medicines in the preceding 3 months.ResultsCompared with before the introduction of the new regulations, there was a large decline in the reported ‘often’ or ‘regular’ use of codeine-containing medicines in the 3 months before admission (33.3%v. 17.4%,χ2= 6.354,p= 0.01) and there was a reduction in the proportion of patients for whom others had expressed concerns about their frequency of use of such medications (15.5%v. 4.8%,χ2= 7.29,p= 0.03). There was also a decline in the proportion of patients who stated that they would use codeine-containing medicines for either a ‘feel-good’ effect or to curb cravings (15.9%v. 1.9%,p< 0.01, two-tailed Fisher's exact test).ConclusionWe conclude that tight regulations on the supply of non-prescription codeine-containing medicines have the potential to reduce the use and abuse of such medicines in patient populations availing of admission to psychiatry hospitals.
Planning dementia services: new estimates of current and future prevalence rates of dementia for Ireland
Authors: Pierce M. , Cahill S. , O'Shea E. 
Published: March 2013

ObjectivesThe paper provides new estimates of dementia prevalence at a national and local level in Ireland and new projections of future numbers of people with dementia.MethodsThe prevalence of dementia at a national and local level has been calculated by applying European Collaboration on Dementia (EuroCoDe) prevalence rates to data from the Census of Population 2006. The National Disability Survey has been used to estimate the number of people with Down syndrome and dementia. Projections of future numbers of people with dementia have been calculated by applying EuroCoDe prevalence rates to the most recently available population projections from the Central Statistics Office (CSO).ResultsIt is estimated that there were 41 740 people with dementia in Ireland in 2006. Estimates show that there are clear regional differences in prevalence of dementia across Ireland, with the largest proportion of people with dementia in the West of Ireland, and the Dublin North Eastern region having the lowest share of dementia. Our best estimate is that there are 700 people with Down syndrome and dementia in Ireland. Applying EuroCoDe prevalence rates to the most recent CSO population projections shows that the prevalence of dementia in Ireland will increase to between 67 493 and 70 000 in 2021 and to between 140 580 and 147 000 in 2041.ConclusionsAlthough there are several limitations to these estimates, the data provide timely and useful information for planning effective health and social care services, as well as raising public and professional awareness about dementia at a national level.
Extra-virgin olive oil consumption reduces the age-related decrease in HDL and paraoxonase 1 anti-inflammatory activities
Authors: Loued Soumaya , Berrougui Hicham , Componova Pamela , Ikhlef Souad , Helal Olfa , Khalil Abdelouahed 
Published: March 2013

Paraoxonase 1 (PON1) is associated with HDL and modulates the antioxidant and anti-inflammatory role of HDL. The goals of the present study were to investigate the effect of ageing and the role of PON1 on the anti-inflammatory activity of HDL, and to determine whether extra-virgin olive oil (EVOO) consumption could improve the atheroprotective activity of HDL. HDL and PON1 were isolated from the plasma of ten young (Y-HDL and Y-PON1) and ten elderly (E-HDL and E-PON1) healthy volunteers before and after 12 weeks of EVOO consumption. Inflammation was assessed by measuring intracellular adhesion molecule 1 (ICAM-1) expression. THP-1 (human acute monocytic leukaemia cell line) monocyte chemotaxis was measured using a Boyden chamber. Oxidative damage to HDL was assessed by measuring conjugated diene formation and changes in electrophoretic migration. Y-HDL had more anti-inflammatory activity than E-HDL. The conjugated diene content and the electrophoretic mobility of E-HDL were higher than those of Y-HDL. Y-PON1 had significant anti-inflammatory activity, reducing ICAM-1 expression by 32·64 (sd2·63) %, while E-PON1 had no significant effect. THP-1 chemotaxis measurements confirmed the ICAM-1 expression results. The 12 weeks of EVOO consumption significantly increased the anti-inflammatory activities of both HDL and PON1. The anti-inflammatory activity of HDL was modulated by PON1 and was lower in the elderly volunteers. EVOO consumption increased the anti-inflammatory effect of HDL and reduced the age-related decrease in anti-atherogenic activity.
Trophic status and helminth infracommunities of fish populations in Kashmir Himalayan lakes
Authors: Shah H.B. , Yousuf A.R. , Chishti M.Z. , Shahnaz S. , Ahmad F. 
Published: March 2013

AbstractThe present study considers the influence of the trophic status of three Kashmir Himalayan lakes on the patterns of helminth infracommunities in populations of three species of fish during 2006 to 2008. Data were collected from three lakes of differing trophic status in the Kashmir Himalayas, namely Anchar, a hyper(eu)trophic lake; Dal, a eutrophic lake; and Manasbal, a meso(eu)trophic lake. Three species of fish examined included the native fish Schizothorax niger Heckel and two exotic species – Carassius carassius (Linnaeus) and Cyprinus carpio Linnaeus. The analysis of data showed a clear habitat effect on the abundance pattern of helminth species, thus revealing lake-specific differences in parasite infracommunities of both S. niger and C. carassius. Helminth infracommunity richness was the highest in host populations from the Anchar lake compared to other two lakes. Low values in the Manasbal lake emphasize the low diversity of their helminth infracommunities. On the other hand, there was no observed pattern of community structure in the case of C. carpio in the three lake sites. However due to bias in sampling there was no distinct effect of fish body size on parasite infracommunity structure, although the present results do show that fish parasite data can be meaningful in diagnosing changes in the trophic condition of eutrophic lakes.
Family relationships and dementia: a synthesis of qualitative research including the person with dementia
Authors: LA FONTAINE JENNY , OYEBODE JAN R. 
Published: March 2013

ABSTRACTFamily relationships are important for wellbeing across the lifecourse and are known to be important for people living with dementia, bringing benefits to self-esteem and identity, as well as providing support for people living at home. Recent research has explored the impact of dementia upon relationships. Much of this research is qualitative in nature and rarely included in systematic reviews, however, it has the potential to provide significant contributions to understanding the interplay between family relationships and dementia and to inform interventions. A systematic synthesis of qualitative research concerning the impact of dementia upon family relationships was undertaken, using thematic synthesis. Eleven articles were reviewed, which address the perspectives of people living with dementia and their spouse and/or adult children. The aims of this review are to illuminate what is currently known about the reciprocal influences between family relationships and dementia from the perspectives of the family (including the person with dementia); and to consider the implications of these findings for research and practice. Four super-ordinate themes were identified: ‘a shared history’, ‘negotiating the impact of dementia upon the relationship’, ‘openness and awareness’ and ‘shifting sands’. This synthesis contributes to an emerging field but also highlights gaps in current understanding of the impact of dementia upon relationships and in providing appropriate interventions. Implications for research and practice are considered.
Forest-fragment quality rather than matrix habitat shapes herbivory on tree recruits in South Africa
Authors: Botzat Alexandra , Fischer Lena , Farwig Nina 
Published: March 2013

Abstract:Forest fragmentation can alter herbivory on tree recruits with possible consequences for regeneration. We assessed effects of forest-fragment quality (tree diversity, vegetation complexity, relative abundance of pioneer trees) and matrix habitat on arthropods and herbivory in KwaZulu-Natal, South Africa. We compared arthropod abundances and herbivory on woody seedlings and saplings among four forest-fragment types differing in size and matrix (large fragments and small fragments surrounded by natural grassland, eucalypt and sugarcane plantations; nplots = 24) using analyses of covariance. We recorded 3385 arthropods and inspected 897 seedlings (71 species) and 876 saplings (91 species). Relative abundance of predators increased with fragment quality; that of herbivores decreased. Herbivory responses to fragment quality varied: seedling herbivory decreased with relative abundance of pioneers and sapling herbivory increased with vegetation complexity. Matrix effects were low with little variation in relative abundance of predators (0.39–0.53) and herbivores (0.22–0.32), proportion of seedling (8.3–11.0%) and sapling herbivory (12.4–14.3%) among the forest-fragment types. These findings indicate that herbivory on tree recruits is mediated by forest-fragment quality rather than matrix habitat. Future studies should evaluate whether contrasting effects of fragment quality on arthropods and herbivory are caused by weak trophic interactions and variable herbivore compositions.
Interaction between distant taxa in the use of tree cavities in African ecosystems: a study using nest-boxes
Authors: Veiga José P. , Wamiti Wanyoike , Polo Vicente , Muchai Muchane 
Published: March 2013

Abstract:Convergence in the use of resources may occur between distantly related organisms. A major ecological resource in which members of various taxa may be interested is a cavity for nesting. A variety of social hymenopterans and vertebrates may nest within tree cavities in tropical ecosystems. We used 241 nest-boxes placed in seven Kenyan localities to investigate the use of nesting cavities by members of distant taxa and discuss whether interaction between them is a potential factor shaping cavity-nester communities in tropical regions. The nest-boxes were occupied by social insects (ants, bees and wasps) (30.1% of nest-boxes in April–May and 33.1% in September–October) and vertebrates (birds and mammals) (20% and 7.7%, respectively). Hymenopterans were more abundant in forest boxes (36.2% of nest-boxes occupied in April–May and 37% in September–October), whereas savannas had lower figures (21.7% and 31.3%, respectively). Among vertebrates, most occupants of nest-boxes in savanna were birds (17.8% of nest-boxes occupied vs. 8% in mammals), while mammals predominated in forests (4.9% of the nest-boxes occupied vs. 0.3% in birds). Spatial and temporal patterns of occupation highlight the potential that interaction between distant taxa may have on the access to nesting cavities. More nest-boxes remained unoccupied in forested areas than in savanna areas suggesting that a shorter supply of nesting sites in the savanna may be a source of competition. The simultaneous occupation of a nest-box by two different taxa was exceptional, also supporting the hypothesized inter-taxon competition.
Cities in the ‘long’ Late Antiquity, 2000–2012 – a survey essay
Authors: GRIG LUCY 
Published: March 2013

ABSTRACT:This essay surveys major themes and developments in the recent study of late antique urbanism. First, re-evaluations of the late phase of classical urbanism are discussed, whereby a simple narrative of ‘decline’ has been replaced by a much more chronologically and geographically nuanced picture. The importance of regional, indeed local, specificity is stressed, with different areas of the ancient world experiencing often radically different urban trajectories. Key aspects of late antique urbanism are considered, including the relationship between town and country, economic urban life, political versus social and religious urban history, before concluding with consideration of areas where future research is particularly needed.
Legal Education in China: The New “Outstanding Legal Personnel Education Scheme” and Its Implications
Authors: Shan Wenhua 
Published: March 2013

AbstractAfter more than 60 years of development, the People's Republic of China has established the world's largest size of legal education, with 624 law schools and 450,000 thousands of undergraduate students currently enrolled. As Wenhua Shan explains, whilst the quality of education has also been improved, it generally falls short of meeting the domestic and international challenges that China is facing in legal education and practice. The most important measure recently adopted by the Chinese Government to enhance the quality of legal education, the “Outstanding Legal Personnel Education Scheme”, is poised to bring significant changes to the structure, contents and methods of Chinese legal education; and it will boost deeper cooperation between law schools and the practice sectors. Further measures are nevertheless required to achieve the desired results of the scheme and to place Chinese legal education in an internationally competitive position.
Among neighbors: An ethnographic account of responsibilities in rural palliative care
Authors: Pesut Barbara , Robinson Carole A. , Bottorff Joan L. 
Published: March 2013

AbstractObjective:Building high quality palliative care in rural areas must take into account the cultural dimensions of the rural context. The purpose of this qualitative study was to conduct an exploration of rural palliative care, with a particular focus on the responsibilities that support good palliative care from rural participants’ perspectives.Method:This ethnographic study was conducted in four rural communities in Western Canada between June 2009 and September 2010. Data included 51 days of field work, 95 semistructured interviews, and 74 hours of direct participant observation. Thematic analysis was used to provide a descriptive account of rural palliative care responsibilities.Results:Findings focus on the complex web of responsibilities involving family, healthcare professionals, and administrators. Family practices of responsibility included provision of direct care, managing and coordinating care, and advocacy. Healthcare professional practices of responsibility consisted of interpreting their own competency in relation to palliative care, negotiating their role in relation to that interpretation, and individualizing care through a bureaucratic system. Administrators had three primary responsibilities in relation to palliative care delivery in their community: navigating the politics of palliative care, understanding the culture of the community, and communicating with the community.Significance of results:Findings provide important insights into the complex ways rurality influences understandings of responsibility in palliative care. Families, healthcare providers, and administrators work together in fluid ways to support high quality palliative care in their communities. However, the very fluidity of these responsibilities can also work against high quality care, and are easily disrupted by healthcare changes. Proposed healthcare policy and practice changes, particularly those that originate from outside of the community, should undergo a careful analysis of their potential impact on the longstanding negotiated responsibilities.
Polanyi's Revenge
Authors: Martin Lisa L. 
Published: March 2013

Since the beginning of the financial crisis of 2008, authors and politicians have regularly reminded us of the duality of crisis and opportunity. For policymakers, administrations, and candidates, crises represent opportunities to implement long-desired reforms, seize the public stage, and reframe old arguments in the light of today's urgency. As the books under review here suggest, crises also represent opportunities for scholars. Arguments that failed to gain traction in the past may now deserve new attention as they help us understand the roots of crisis or how to recover from it. New audiences may be receptive to established arguments, now that other policies have caused us grief and are failing to promote recovery. The public and decision makers could be open to listening to these arguments and their implications, now that crisis has revealed deep vulnerabilities.The three books that form the basis of this review essay represent trenchant critiques of neoliberal economic theory and policies, including such foundational policy assumptions as globalization, deregulation, and reliance on sophisticated financial tools. Their authors, three prominent economists, draw our attention to problems of market failure, such as rampant rent-seeking behavior and externalities. By focusing on entrenched dilemmas that include widening inequality and the compatibility of democracy and globalization, they remind us of the ways in which markets are embedded in social institutions, and how such institutions both respond to markets and shape market outcomes. All bring with them a deep commitment to understanding the functioning of society and how to maintain the benefits of global capitalism while reining in its most destructive implications.
Targeting CXCL12/CXCR4 signaling with oncolytic virotherapy disrupts tumor vasculature and inhibits breast cancer metastases
Authors: Gil Margaret , Seshadri Mukund , Komorowski Marcin P. , Abrams Scott I. , Kozbor Danuta 
Published: March 2013

SignificanceNovel advances in viral oncotherapy require effective direct oncolysis and manipulation of the tumor microenvironment, which has proven to be an important target in cancer treatment. The CXCR4 receptor for the CXCL12 chemokine is one of the key stimuli involved in signaling interactions between tumor cells and their microenvironment, suggesting that inhibition of this pathway by oncolytic viruses expressing the CXCR4 antagonist should increase efficacy over that mediated by oncolysis alone. We are unique in demonstrating that targeting CXCR4 signaling through an oncolytic vaccinia virus yields a significant therapeutic impact against primary and metastatic breast cancer.
Activationless charge transport across 4.5 to 22 nm in molecular electronic junctions
Authors: Yan Haijun , Bergren Adam Johan , McCreery Richard , Della Rocca Maria Luisa , Martin Pascal , Lafarge Philippe , Lacroix Jean Christophe 
Published: March 2013

In this work, we bridge the gap between short-range tunneling in molecular junctions and activated hopping in bulk organic films, and greatly extend the distance range of charge transport in molecular electronic devices. Three distinct transport mechanisms were observed for 4.5–22-nm-thick oligo(thiophene) layers between carbon contacts, with tunneling operative when
d
< 8 nm, activated hopping when
d
> 16 nm for high temperatures and low bias, and a third mechanism consistent with field-induced ionization of highest occupied molecular orbitals or interface states to generate charge carriers when
d
= 8–22 nm. Transport in the 8–22-nm range is weakly temperature dependent, with a field-dependent activation barrier that becomes negligible at moderate bias. We thus report here a unique, activationless transport mechanism, operative over 8–22-nm distances without involving hopping, which severely limits carrier mobility and device lifetime in organic semiconductors. Charge transport in molecular electronic junctions can thus be effective for transport distances significantly greater than the 1–5 nm associated with quantum-mechanical tunneling.
Contrast of Degraded and Restored Stream Habitat Using an Individual-Based Salmon Model
Authors: Railsback Steven F. , Gard Mark , Harvey Bret C. , White Jason L. , Zimmerman Julie K. H. 
Published: March 2013

Abstract
Stream habitat restoration projects are popular, but can be expensive and difficult to evaluate. We describe inSALMO, an individual-based model designed to predict habitat effects on freshwater life stages (spawning through juvenile out-migration) of salmon. We applied inSALMO to Clear Creek, California, simulating the production of total and large (&gt;5 cm FL) Chinook Salmon Oncorhynchus tshawytscha out-migrants at a degraded and a restored site. The calibrated model reproduced observed redd locations and out-migrant timing and size. In simulations, the restored site had a much higher production of fry that established and grew before out-migration; it provided higher survival and positive growth due to moderate velocities, shallow depths, and cover for feeding and hiding. The restored site did not produce more total out-migrants because at both sites spawning gravel was sufficient and the vast majority of fry moved downstream soon after emergence. Simulations indicated that at both sites increasing food and cover availability could further increase production of large, but not total, out-migrants; spawning gravel, temperature, and flow appear nearly optimal already. Further gravel addition was predicted to increase total fry production but have little or even a negative effect on production of large out-migrants, illustrating that actions benefitting one life stage can negatively affect others. The model predicted that further enhancements (e.g., in cover availability) would be more beneficial at the restored site than at the degraded site. Restoration efforts may be most effective when concentrated in “hot spots” with good habitat for growth and predator avoidance as well as for spawning. Contradicting the traditional notion of “limiting factors,” the model indicated that several factors each have strong effects. The model provided more understanding of restoration effects than would field studies alone and could be useful for designing projects to meet specific restoration objectives.
Received June 23, 2012; accepted January 2, 2013