bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced mechanical properties and bactericidal activity of polypropylene nanocomposite with dual‐function silica–silver core‐shell nanoparticles
Authors: Suktha Phansiri , Lekpet Kannika , Siwayaprahm Patcharaporn , Sawangphruk Montree 
Published: October 2012

AbstractDual‐function silica–silver core‐shell (SiO2@Ag) nanoparticles (NPs) with the core diameter of 17 ± 2 nm and the shell thickness of about 1.5 nm were produced using a green chemistry. The SiO2@Ag NPs were tested in vitro against gram‐positive Staphylococcus aureus (S. aureus) and gram‐negative Escherichia coli (E. coli), both of which are human pathogens. Minimal inhibitory concentrations of the SiO2@Ag NPs based on Ag content are 4 and 10 μg mL−1 against S. aureus and E. coli, respectively. These values are similar to those of Ag NPs. SiO2@Ag NPs were for the first time incorporated to a commodity polypropylene (PP) polymer. This yielded an advanced multifunctional polymer using current compounding technologies i.e., melt blending by twin‐screw extruder and solvent (toluene) blending. The composite containing 5 wt % SiO2@Ag NPs (0.05 wt % Ag) exhibited efficient bactericidal activity with over 99.99% reduction in bacterial cell viability and significantly improved the flexural modulus of the PP. Anodic stripping voltammetry, used to investigate the antibacterial mechanism of the composite, indicated that a bactericidal Ag+ agent was released from the composite in an aqueous environment. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Comparison of autoantibody specificities between traditional and bead‐based assays in a large, diverse collection of patients with systemic lupus erythematosus and family members
Authors: Bruner Benjamin F. , Guthridge Joel M. , Lu Rufei , Vidal Gabriel , Kelly Jennifer A. , Robertson Julie M. , Kamen Diane L. , Gilkeson Gary S. , Neas Barbara R. , Reichlin Morris , Scofield R. Hal , Harley John B. , James Judith A. 
Published: October 2012

AbstractObjectiveReplacement of standard immunofluorescence methods with bead‐based assays for antinuclear antibody (ANA) testing is a new clinical option. The aim of this study was to evaluate a large, multiethnic cohort of patients with systemic lupus erytematosus (SLE), blood relatives, and unaffected control individuals for familial aggregation and subset clustering of autoantibodies by high‐throughput serum screening technology and traditional methods.MethodsSerum samples (1,540 SLE patients, 1,154 unaffected relatives, and 906 healthy, population‐based controls) were analyzed for SLE autoantibodies using a bead‐based assay, indirect immunofluorescence (IIF), and immunodiffusion. Autoantibody prevalence, sensitivity for disease detection, clustering of autoantibodies, and associations between newer methods and standard immunodiffusion results were evaluated.ResultsThe frequencies of ANAs in the sera from African American, Hispanic, and European American patients with SLE were 89%, 73%, and 67%, respectively, by BioPlex 2200 bead‐based assay and 94%, 84%, and 86%, respectively, by IIF. When comparing the serum prevalence of 60‐kd Ro, La, Sm, nuclear RNP A, and ribosomal P autoantibodies across assays, the sensitivity of detection ranged from 0.92 to 0.83 and the specificity ranged from 0.90 to 0.79. Autoantibody cluster analysis showed associations of autoantibody specificities in 3 subsets: 1) 60 kd Ro, 52‐kd Ro, and La, 2) spliceosomal proteins, and 3) double‐stranded DNA (dsDNA), chromatin, and ribosomal P. Familial aggregation of Sm/RNP, ribosomal P, and 60‐kd Ro in SLE patient sibling pairs was observed (P ≤ 0.004). Simplex‐pedigree SLE patients had a greater prevalence of dsDNA (P = 0.0003) and chromatin (P = 0.005) autoantibodies compared to patients with a multiplex SLE pedigree.ConclusionThe frequencies of ANAs detected by a bead‐based assay are lower than those detected by IIF in European American patients with SLE. These assays have strong positive predictive values across ethnic groups, provide useful information for clinical care, and provide unique insights into familial aggregation and autoantibody clustering.
Leader‐Following Consensus of Multi‐Agent System with Diffusion
Authors: Guo Ling , Nian Xiaohong , Pan Huan 
Published: October 2012

AbstractThis paper is concerned with the leader‐following consensus problem for multi‐agent systems consisting of one stationary leader and multiple cooperative followers, where the controlling effect of each follower depends on its own state. It is noted that the influence of diffusion among followers is taken into account and the system is modeled by reaction‐diffusion equations. With the assumption of the followers' initial states, a linear control protocol is designed. Based on algebraic graph theory, the method of energy estimates, and Sobolev embedding theorem, the sufficient conditions guaranteeing the leader‐following consensus under the proposed control protocol are provided. Numerical examples illustrate the effectiveness of the theoretical results.
Urban–rural disparities in colorectal cancer screening: cross‐sectional analysis of 1998–2005 data from the Centers for Disease Control's Behavioral Risk Factor Surveillance Study
Authors: Cole Allison M. , Jackson J. Elizabeth , Doescher Mark 
Published: October 2012

AbstractDespite the existence of effective screening, colorectal cancer remains the second leading cause of cancer death in the United States. Identification of disparities in colorectal cancer screening will allow for targeted interventions to achieve national goals for screening. The objective of this study was to contrast colorectal cancer screening rates in urban and rural populations in the United States. The study design comprised a cross‐sectional study in the United States 1998–2005. Behavioral Risk Factor Surveillance System data from 1998 to 2005 were the method and data source. The primary outcome was self‐report up‐to‐date colorectal cancer screening (fecal occult blood test in last 12 months, flexible sigmoidoscopy in last 5 years, or colonoscopy in last 10 years). Geographic location (urban vs. rural) was used as independent variable. Multivariate analysis controlled for demographic and health characteristics of respondents. After adjustment for demographic and health characteristics, rural residents had lower colorectal cancer screening rates (48%; 95% CI 48, 49%) as compared with urban residents (54%, 95% CI 53, 55%). Remote rural residents had the lowest screening rates overall (45%, 95% CI 43, 46%). From 1998 to 2005, rates of screening by colonoscopy or flexible sigmoidoscopy increased in both urban and rural populations. During the same time, rates of screening by fecal occult blood test decreased in urban populations and increased in rural populations. Persistent disparities in colorectal cancer screening affect rural populations. The types of screening tests used for colorectal cancer screening are different in rural and urban areas. Future research to reduce this disparity should focus on screening methods that are acceptable and feasible in rural areas.
Association of diabetes and perineural invasion in pancreatic cancer
Authors: Sahin Ibrahim Halil , Shama Mohamed A. , Tanaka Motofumi , Abbruzzese James L. , Curley Steven A. , Hassan Manal , Li Donghui 
Published: October 2012

AbstractDiabetes and perineural invasion are frequently observed in pancreatic cancer. In this study, we tested possible relations between diabetes and perineural invasion in patients with resected pancreatic cancer. We conducted a retrospective study in 544 cases of resected pancreatic adenocarcinoma seen at the University of Texas MD Anderson Cancer Center during 1996–2011. Information on tumor characteristics, diabetes history, and survival time was collected by personal interview and medical record review. Patients with diabetes before or at the time of the pancreatic cancer diagnosis were considered diabetes only. Pearson χ2 test was used to compare categorical variables in diabetic and nondiabetic groups. Kaplan–Meier plot, log‐rank test, and Cox proportional regression models were applied in survival analysis. The prevalence of diabetes and perineural invasion was 26.5% and 86.9%, respectively, in this study population. Patients with diabetes had a significantly higher prevalence of perineural invasion (92.4%) than those without diabetes (85%) (P = 0.025, χ2 test). Diabetes was not associated with other pathological characteristics of the tumor, such as tumor size, lymphovascular invasion, tumor grade, lymph node metastasis, and resection margin status. Diabetic patients had a significantly lower frequency of abdominal pain (P = 0.01), but a slightly higher frequency of weight loss (P = 0.078) as early symptoms of their cancer. Both diabetes and perineural invasion were related to worse survival and increased risk of death after adjusting for tumor grade and margin and node status (P = 0.036 and 0.019, respectively). The observed associations of diabetes and perineural invasion as well as reduced frequency of pain as early symptom of pancreatic cancer support the hypothesis that diabetes may contribute to pancreatic progression via the mechanism of nerve damage.
Two Synthetic Antibodies that Recognize and Neutralize Distinct Proteolytic Forms of the Ebola Virus Envelope Glycoprotein
Authors: Koellhoffer Jayne F. , Chen Gang , Sandesara Rohini G. , Bale Shridhar , Ollmann Saphire Erica , Chandran Kartik , Sidhu Sachdev S. , Lai Jonathan R. 
Published: October 2012

AbstractEbola virus (EBOV) is a highly pathogenic member of the Filoviridae family of viruses that causes severe hemorrhagic fever. Infection proceeds through fusion of the host cell and viral membranes, a process that is mediated by the viral envelope glycoprotein (GP). Following endosomal uptake, a key step in viral entry is the proteolytic cleavage of GP by host endosomal cysteine proteases. Cleavage exposes a binding site for the host cell receptor Niemann‐Pick C1 (NPC1) and may induce conformational changes in GP leading to membrane fusion. However, the precise details of the structural changes in GP associated with proteolysis and the role of these changes in viral entry have not been established. Here, we have employed synthetic antibody technology to identify antibodies targeting EBOV GP prior to and following proteolysis (i.e. in the “uncleaved” [GPUNCL] and “cleaved” [GPCL] forms). We identified antibodies with distinct recognition profiles: FabCL bound preferentially to GPCL (EC50=1.7 nM), whereas FabUNCL bound specifically to GPUNCL (EC50=75 nM). Neutralization assays with GP‐containing pseudotyped viruses indicated that these antibodies inhibited GPCL‐ or GPUNCL‐mediated viral entry with specificity matching their recognition profiles (IC50: 87 nM for IgGCL; 1 μM for FabUNCL). Competition ELISAs indicate that FabCL binds an epitope distinct from that of KZ52, a well‐characterized EBOV GP antibody, and from that of the luminal domain of NPC1. The binding epitope of FabUNCL was also distinct from that of KZ52, suggesting that FabUNCL binds a novel neutralization epitope on GPUNCL. Furthermore, the neutralizing ability of FabCL suggests that there are targets on GPCL available for neutralization. This work showcases the applicability of synthetic antibody technology to the study of viral membrane fusion, and provides new tools for dissecting intermediates of EBOV entry.
Rare Earth‐doped Ceria Catalysts for ODHE Reaction in a Catalytic Modified MIEC Membrane Reactor
Authors: Lobera M. Pilar , Balaguer María , Garcia‐Fayos Julio , Serra José M. 
Published: October 2012

AbstractAn intensification process for the selective oxidation of hydrocarbons integrates a catalytic reactor and an oxygen separation membrane. This work presents the study of oxidative dehydrogenation of ethane at 1123 K in a catalytic membrane reactor based on mixed ionic‐electronic conducting (MIEC) membranes. The surface of a membrane made of Ba0.5Sr0.5Co0.8Fe0.2O3−δ has been activated using different porous catalytic layers based on rare earth‐doped cerias (fluorite structure) and the porous catalytic coating was deposited by screen printing (coating around 15 μm). The different catalyst formulations were developed by partial substitution of Ce and were synthesized by co‐precipitation followed by cobalt impregnation when required. Specifically, seven different catalysts based on the system Ce1−xLnxO2−δ (x=0.1 or 0.2; Ln=Tb, Pr, Er, Gd, and Tb+Er), including the effect of cobalt addition (2 % molar) in Ce0.8Tb0.2O2−δ, were studied. The ceria catalysts were studied by XRD, SEM, DC‐conductivity as a function of oxygen partial pressure, and the high‐temperature stability in a CO2 environment was assessed using thermogravimetry. Then, the influence of the ceria catalytic coating on the oxygen permeation flux through the MIEC membrane was studied using argon and methane as the sweep gas in the permeate side. Finally, oxidative dehydrogenation of ethane reaction tests were performed at 1123 K, as a function of the ethane concentration in the feed. The use of a disk‐shaped membrane in the reactor made it possible to prevent the direct contact of gaseous oxygen and hydrocarbons and thus to increase the ethylene yield. High ethylene yields (up to ≈84 %) were obtained using a catalytic coating based on 20 % Tb‐doped ceria including macropores produced by the addition of graphite platelets in the screen printing ink. The high yields obtained in this kind of catalytic membrane are attributed to the combination of: the high catalytic activity; the control of the oxygen concentration in the gas phase (reaction chamber); and the appropriate fluid dynamics, enabling the fast ethylene evacuation.
CPMD Simulation of a Bimolecular Chemical Reaction: Nucleophilic Attack of a Disulfide Bond under Mechanical Stress
Authors: Hofbauer Florian , Frank Irmgard 
Published: October 2012

AbstractPrevious single‐molecule atomic force microscopy (AFM) experiments showed a change in the reactivity of a bimolecular substitution reaction with a definite force acting on a protein containing disulfide bonds. Using Car–Parrinello molecular dynamics (CPMD) simulations, we analyse the relevant reaction pathways for the breaking of a disulfide bond in the presence of nucleophiles.
Phosphorylated 3‐Heteroarylcoumarins and Their Use in Fluorescence Microscopy and Nanoscopy
Authors: Nizamov Shamil , Willig Katrin I. , Sednev Maksim V. , Belov Vladimir N. , Hell Stefan W. 
Published: October 2012

AbstractPhotostable and bright fluorescent dyes with large Stokes shifts are widely used as markers in far‐field optical microscopy, but the variety of useful dyes is limited. The present study introduces new 3‐heteroaryl coumarins decorated with a primary phosphate group (OP(O)(OH)2) attached to C‐4 in 2,2,4‐trimethyl‐1,2‐dihydroquinoline fragment fused with the coumarin fluorophore. The general synthetic route is based on the Suzuki reaction of 3‐bromocoumarines with hetarylboronic acids followed by oxidation of the methyl group at the CC bond with SeO2 (to an aldehyde), reduction with NaBH4 (to an alcohol), and conversion into a primary phosphate. The 4 position in the coumarin system may be unsubstituted or bear a methyl group. Phosphorylated coumarins were found to have high fluorescence quantum yields in the free state and after conjugation with proteins (in aqueous buffers). In super‐resolution light microscopy with stimulated emission depletion (STED), the new coumarin dyes provide an optical resolution of 40–60 nm with a low background signal. Due to their large Stokes shifts and high photostability, phosphorylated coumarins enable to combine multilabel imaging (using one detector and several excitation sources) with diffraction unlimited optical resolution.
Mechanistic Origin of Cross‐Coupling Selectivity in Ni‐Catalysed Tishchenko Reactions
Authors: Yu Haizhu , Fu Yao 
Published: October 2012

AbstractMechanistic studies have been performed for the recently developed, Ni‐catalysed selective cross‐coupling reaction between aryl and alkyl aldehydes. A mono‐carbonyl activation (MCA) mechanism (in which one of the carbonyl groups is activated by oxidative addition) was found to be the most favourable pathway, and the rate‐determining step is oxidative addition. Analysing the origin of the observed cross‐coupling selectivity, we found the most favourable carbonyl activation step requires both coordination of the aryl aldehyde and oxidative addition of the alkyl aldehyde. Therefore, the stronger π‐accepting ability of the aryl aldehyde (relative to alkyl aldehyde) and the ease of oxidative addition of the alkyl aldehyde (relative to aryl aldehyde) are responsible for the cross‐coupling selectivity.
ChemInform Abstract: Improving the Performance of High Capacity Li‐Ion Anode Materials by Lithium Titanate Surface Coating.
Authors: Ji Ge , Ma Yue , Ding Bo , Lee Jim Yang 
Published: October 2012

AbstractSnO2@Li4Ti5O12 core—shell composite particles are prepared by deposition of titania on hollow SnO2 nanoparticles followed by dispersion of the titania‐coated hollow tin oxide nanoparticles in aqueous LiOH solution (autoclave, 180 °C, 20 h).
ChemInform Abstract: A Facile and Low Cost Synthesis of Earth Abundant Element Cu2ZnSnS4 (CZTS) Nanocrystals: Effect of Cu Concentrations.
Authors: Lee Jeong Yong , et al. et al. 
Published: October 2012

AbstractNanocrystals of the title compound are synthesized by sulfurization (5% H2S/N2, 550 °C, 1 h) of precursors obtained by microwave irradiation of solutions containing Cu(OAc)2, Zn(OAc)2, SnCl2, thioacetamide, and NH4OH.
ChemInform Abstract: Highly Stereoselective Ru(II)—Pheox Catalyzed Asymmetric Cyclopropanation of Terminal Olefins with Succinimidyl Diazoacetate.
Authors: Chanthamath Soda , Phomkeona Kesiny , Shibatomi Kazutaka , Iwasa Seiji 
Published: October 2012

AbstractA novel two‐step procedure is developed for the synthesis of cyclopropylmethanol derivatives (IV) with high diastereo‐ and enantioselectivity.
ChemInform Abstract: TEMPO Mediated Oxidation of Fluorinated Alcohols to Carboxylic Acids.
Authors: Ignatowska Jolanta , Shyshkov Oleg , Zipplies Tilman , Hintzer Klaus , Roeschenthaler Gerd‐Volker 
Published: October 2012

AbstractThe reaction can also be conducted with oxygen as oxidant.
ChemInform Abstract: Ruthenium(II)‐Catalyzed sp3 C—H Bond Arylation of Benzylic Amines Using Aryl Halides.
Authors: Dastbaravardeh Navid , Schnuerch Michael , Mihovilovic Marko D. 
Published: October 2012

AbstractAryl iodides (IV) produce lower yields compared to bromides; aryl chlorides inhibit the reaction completely.
ChemInform Abstract: Diastereoselective Addition of Chlorotitanium Enolate Derived from 2′‐Hydroxypropiophenone to Aldehydes.
Authors: Deng Guisheng , Mo Honghua 
Published: October 2012

AbstractUsually the reaction of chlorotitanium enolate derived from 2′‐hydroxypropiophenone (I) with aldehydes produces syn‐aldol products (III) and (VI).
ChemInform Abstract: [Pd(μ‐Br)(PtBu3)]2 as a Highly Active Isomerization Catalyst: Synthesis of Enol Esters from Allylic Esters.
Authors: Mamone Patrizia , Gruenberg Matthias F. , Fromm Andreas , Khan Bilal A. , Goossen Lukas J. 
Published: October 2012

AbstractCompared to Pd(II) or Pd(0) catalysts, the Pd(I) dimer permits the double bond migration of a wide range of unsaturated substrates which can be further hydrogenated in the presence of a chiral system to optically active saturated esters.
ChemInform Abstract: Catalytic Asymmetric Mannich‐Type Reactions of α‐Cyano α‐Sulfonyl Carbanions.
Authors: Ohmatsu Kohsuke , Goto Ayano , Ooi Takashi 
Published: October 2012

AbstractThe ability of the chiral triazolium salt for structural modularity and anion‐recognition allows for rigorous enantiocontrol.
ChemInform Abstract: Synthesis of Fullerene‐Containing Methacrylates (I)
Authors: Torosyan Seda A. , Biglova Yulia N. , Mikheev Vladimir V. , Khalitova Zarina T. , Gimalova Fanuza A. , Miftakhov Mansur S. 
Published: October 2012

Abstractvia Bingel—Hirsch reaction
ChemInform Abstract: A New Knoevenagel‐Type Synthesis of Fully Substituted γ‐Hydroxybutenolides.
Authors: Lamberth Clemens , Godineau Edouard , Smejkal Tomas , Trah Stephan 
Published: October 2012

AbstractA novel method is developed for the synthesis of fully substituted γ‐hydroxybutenolides via Knoevenagel‐type ring condensation of α‐methyleneketones and α‐ketoesters.
ChemInform Abstract: An Indium‐Mediated Allylative/Transesterification DFT‐Directed Approach to Chiral C(3)‐Functionalized Phthalides.
Authors: Mirabdolbaghi Roya , Dudding Travis 
Published: October 2012

AbstractUsing a solid support (R2: Merrifield resin), only the racemic phthalide (IIIa) is obtained.
ChemInform Abstract: Synthesis of 3‐Substituted 2‐Amino‐1‐hydroxy‐1H‐indole‐5,6‐dicarbonitriles.
Authors: Filimonov S. I. , Chirkova Zh. V. , Sharunov V. S. , Abramov I. G. , Stashina G. A. , Firgang S. I. , Suponitsky K. Yu. 
Published: October 2012

AbstractReductive cyclization of readily available 4‐cyanomethyl‐5‐nitrophthalonitriles (III) using a solution of divalent tin in hydrochloric acid produces new indoledicarbonitriles (IV) in good yield.
ChemInform Abstract: The Highly Enantioselective Addition of Indoles and Pyrroles to Isatins‐Derived N‐Boc Ketimines Catalyzed by Chiral Phosphoric Acids.
Authors: Feng Jingchao , Yan Wenjin , Wang Dong , Li Peng , Sun Quantao , Wang Rui 
Published: October 2012

AbstractThis approach represents the first enantioselective aza‐Friedel—Crafts reaction with isatin‐derived ketimines as electrophiles catalyzed by chiral phosphonic acids.
ChemInform Abstract: 3,4‐Dihydroxypyrrolidines via Modified Tandem Aza‐Payne/Hydroamination Pathway.
Authors: Kulshrestha Aman , Marzijarani Nastaran Salehi , Ashtekar Kumar Dilip , Staples Richard , Borhan Babak 
Published: October 2012

AbstractThe carboxylation of aziridine derivatives bearing a silylated propargylic alkoxy group proceeds in the presence of Bu4NF and NaHCO3 to afford the target fused enamine carbonates in good yields.
ChemInform Abstract: Xanthan Sulfuric Acid: An Efficient, Biosupported, and Recyclable Solid Acid Catalyst for the Synthesis of 4,4′‐(Arylmethylene)bis(1H‐pyrazol‐5‐ols).
Authors: Kuarm B. Suresh , Rajitha B. 
Published: October 2012

AbstractAll products are purified by recrystallization.
ChemInform Abstract: Direct Transition Metal Free C—S Bond Formation: Synthesis of 2‐Aminobenzothiazole Derivatives via Base‐Mediated Approach.
Authors: Wang Rui , Chen Zhi , Yue Liang , Pan Wei , Zhao Jun‐Jie 
Published: October 2012

AbstractA broad spectrum of target compounds bearing N‐aryl parts at C‐2 is prepared under optimized conditions following 2 different approaches.
ChemInform Abstract: Ni‐Catalyzed Alkenylation of Triazolopyridines: Synthesis of 2,6‐Disubstituted Pyridines.
Authors: Liu Sheng , Sawicki James , Driver Tom G. 
Published: October 2012

AbstractThe process tolerates a broad spectrum of alkyl‐and arylsubstituted alkynes: terminal or silyl‐substituted acetylenes are not converted.
ChemInform Abstract: Facile Synthesis of Coumarin Bioisosteres—1,2‐Benzoxathiine 2,2‐Dioxides.
Authors: Grandane Aiga , Belyakov Sergey , Trapencieris Peteris , Zalubovskis Raivis 
Published: October 2012

AbstractA general and reproducible protocol for preparation of the title compounds is developed with a view to studies on novel carbonic anhydrase inhibitors.
ChemInform Abstract: Synthesis of 4‐Alkynyl‐Substituted 3,4‐Dihydropyrimidin‐2(1H)‐ones.
Authors: Novokshonov Vladimir V. , Novokshonova Irina A. , Nguyen Hien T. T. , Medvedeva Alevtina S. 
Published: October 2012

AbstractThe presented approach is compared to methods using hydrochloric acid in methanol or trimethyl chlorosilane in DMF and is found to give the best results.
ChemInform Abstract: Synthesis of Some Novel Fused Azole Derivatives.
Authors: Soliman A. M. , Sultan A. A. , El Remaily M. A. A. , Abdel‐Ghany H. 
Published: October 2012

AbstractReaction of aminopyrazolecarbonitrile (I) with formic acid, formamide, thioacetamide, carbon disulfide and iso(thio)cyanates provides access to a variety of pyrazolo‐fused pyrimidines.