bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subjective Successful Aging in the Presence of Mobility Disability
Authors: Khamzina Madina , Rogers Wendy A 
Published: July 2024

Abstract

Background and Objectives
Researchers often define successful aging as freedom from disability and disease, yet the perceptions of older adults living with disability challenge this conception, demonstrating that they can indeed age successfully. This paper adapts a framework of successful aging with disability, basing it on the subjective assessment of key components contributing to success among older adults living with mobility disability due to multiple sclerosis.

Research Design and Methods
Employing a qualitative, theory-grounded methodology, we conducted semi-structured interviews with 20 individuals aged 60-75 who live with mobility disability attributed to multiple sclerosis. The open-ended questions explored their perspectives on the aging process, their definition of successful aging, and the coping strategies they employ in navigating challenges associated with age and their condition.

Results
Despite facing mobility disabilities, the majority (16 out of 20) expressed a sense of successful aging, identifying five key themes: accepting reality, maintaining a positive attitude, fostering independence, nurturing a social life, and preserving cognitive abilities. They achieved successful aging by focusing on alternatives, relying on external support, having a good attitude and faith, and accepting their challenges.

Discussion and Implications
The themes identified in this research contribute to redefining successful aging in future studies and facilitating the development of interventions aimed at improving the quality of life for older adults coping with mobility disability.
In Vitro Exposure of Treponema pallidum to Subbactericidal Doxycycline Did Not Induce Resistance: Implications for Doxycycline Postexposure Prophylaxis
Authors: Tantalo Lauren C , Luetkemeyer Anne F , Lieberman Nicole A P , Nunley B Ethan , Avendaño Carlos , Greninger Alexander L , Celum Connie , Giacani Lorenzo 
Published: July 2024

Abstract
Doxycycline postexposure prophylaxis (doxy-PEP) could significantly reduce syphilis incidence. However, the increase in intermittent doxycycline usage might select resistant Treponema pallidum strains. To assess whether resistance to doxycycline could be induced in this pathogen, we exposed the SS14 strain in vitro, both intermittently and continuously, to a subbactericidal doxycycline concentration that still exerts antibiotic pressure. During and after each exposure experiment, we assessed the doxycycline minimal inhibitory concentration in test and control treponemes and performed whole-genome sequencing, concluding that no resistance developed. This work suggests that doxycycline-resistant T. pallidum is not an immediate threat for doxy-PEP implementation.
The Kinematics of Proal Chewing in Rats
Authors: McParland E D , Mitchell J K , Laurence-Chasen J D , Aspinwall L C , Afolabi O , Takahashi K , Ross C F , Gidmark N J 
Published: July 2024

Synopsis
Chewing kinematics are well-documented in several mammal species with fused mandibular symphyses, but relatively understudied in mammals with an unfused symphysis, despite the fact that more than half of extant Mammalia have an unfused mandibular symphysis. The Wistar brown rat (Rattus norvegicus) is widely used in human health research, including studies of mastication or neurological studies where mastication is the output behavior. These animals are known to have unfused mandibular symphyses and proal jaw (rostrocaudal) motion during occlusion, but the lack of high resolution, 3-dimensional analysis of rat chewing leaves the functional significance of symphyseal mobility unknown. We used biplanar fluoroscopy and the X-ray reconstruction of moving morphology workflow to quantify chewing kinematics in 3 brown rats, quantifying overall jaw kinematics, including motions about the temporomandibular joint and unfused mandibular symphysis. During occlusion, the teeth and the mandibular condyle translate almost exclusively anteriorly (proal) during occlusion, with little motion in any other degrees of freedom. At the symphysis, we observed minimal flexion throughout the chew cycle. Overall, there are fundamental differences in jaw kinematics between rats and other mammals and therefore rats are not an appropriate proxy for ancestral mammal jaw mechanics. Additionally, differences between humans and rat chewing kinematics must be considered when using rats as a clinical model for pathological feeding research.
Between Probability and Possibility: Fostering Productive Research in a Dystopian Moment
Authors: Avant Deborah 
Published: July 2024

Abstract
Scholars endeavor to understand the world in order to make it better. To do that, they should pay attention not only to probability but also possibility. I argue that accepting, and centering, the uncertainty endemic to the human condition and human relations could lead to at least two productive shifts. First, it could encourage holding tensions between particularity and generalization, description and theorization, and complexity and simplicity rather than resolving them a priori. This would promote more genuine thinking about the issues we study. Second, it could encourage critical reasoning about both epistemological bias and the limits of utopian ideas, leading to more serious ethical and normative considerations. I encourage honest conversations about the ubiquity of uncertainty and braver efforts to hold tensions, use our judgement and think. Holding space for unpredictability and imperfection promises to both yield better arguments about probability and open up insights into what is possible. It will thus foster research that best meets the demands of our time.
Examining the Impact of Digital Jury Moderation on the Polarization of U.S. Political Communities on Social Media
Authors: Micek Christopher , Solovey Erin T 
Published: July 2024

Abstract
The increased prevalence of misinformation and inflammatory rhetoric online has amplified polarization on social media platforms in the United States, propelling a feedback loop resulting in the erosion of democratic norms. We conducted a study assessing how a social media platform employing appointed moderators would impact the polarization of its users compared to a peer-based digital jury moderation system, which may be better able to harness community knowledge and cultural nuances while fostering a sense of inclusion and trust in the moderation process. Although our study did not observe a significant impact on the polarization of moderators or users, moderators on average viewed the system as just, legitimate and effective at reducing harmful content. Furthermore, there were no significant differences between user perceptions of the content they were shown from either system, indicating that implementing such a peer-based system has the benefit of providing users agency in platform governance without adversely impacting user experience.
Microaerobic-mediated suppression of Klebsiella pneumoniae mucoviscosity is restored by rmpD overexpression
Authors: Sun Wangnan , Rong Chengbo , Chen Liang , Li Jiarui , An Zhijing , Yue Jinglin , Wei Hengkun , Han Kai , Hua Mingxi , Zeng Hui , Chen Chen 
Published: July 2024

Abstract

Aims
Hypervirulent Klebsiella pneumoniae (hvKp) causes invasive community-acquired infections in healthy individuals, and hypermucoviscosity (HMV) is the main phenotype associated with hvKp. This study investigates the impact of microaerobic environment availability on the mucoviscosity of K. pneumoniae.

Methods and results
By culturing 25 clinical strains under microaerobic and aerobic environments, we observed a notable reduction in mucoviscosity in microaerobic environments. RNA sequencing and qRT-PCR revealed downregulated expressions of capsule synthesis genes (galf, orf2, wzi, wza, wzb, wzc, wcaj, manC, manB, and ugd) and regulatory genes (rmpA, rmpD, and rmpC) under microaerobic conditions. Transmission electron microscopy and Indian ink staining analysis were performed, revealing that the capsular thickness of K. pneumoniae decreased by half in microaerobic conditions compared to aerobic conditions. Deletion of rmpD and rmpC caused the loss of the HMV phenotype in both aerobic and microaerobic conditions. However, compared to wild-type strain in microaerobic condition, only rmpD overexpression strain, and not rmpC overexpression strain, displayed a significant increase in capsule thickness in microaerobic conditions.

Conclusions
Microaerobic conditions can suppress the mucoviscosity of K. pneumoniae, but this suppression can be overcome by altering the expression of rmpD, indicating a specific function for rmpD in the oxygen environmental adaptation of K. pneumoniae.
A scoping review of rule-based clinical decision support malfunctions
Authors: Thayer Jeritt G , Franklin Amy , Miller Jeffrey M , Grundmeier Robert W , Rogith Deevakar , Wright Adam 
Published: July 2024

Abstract

Objective
Conduct a scoping review of research studies that describe rule-based clinical decision support (CDS) malfunctions.

Materials and Methods
In April 2022, we searched three bibliographic databases (MEDLINE, CINAHL, and Embase) for literature referencing CDS malfunctions. We coded the identified malfunctions according to an existing CDS malfunction taxonomy and added new categories for factors not already captured. We also extracted and summarized information related to the CDS system, such as architecture, data source, and data format.

Results
Twenty-eight articles met inclusion criteria, capturing 130 malfunctions. Architectures used included stand-alone systems (eg, web-based calculator), integrated systems (eg, best practices alerts), and service-oriented architectures (eg, distributed systems like SMART or CDS Hooks). No standards-based CDS malfunctions were identified. The “Cause” category of the original taxonomy includes three new types (organizational policy, hardware error, and data source) and two existing causes were expanded to include additional layers. Only 29 malfunctions (22%) described the potential impact of the malfunction on patient care.

Discussion
While a substantial amount of research on CDS exists, our review indicates there is a limited focus on CDS malfunctions, with even less attention on malfunctions associated with modern delivery architectures such as SMART and CDS Hooks.

Conclusion
CDS malfunctions can and do occur across several different care delivery architectures. To account for advances in health information technology, existing taxonomies of CDS malfunctions must be continually updated. This will be especially important for service-oriented architectures, which connect several disparate systems, and are increasing in use.
Multi-modality risk prediction of cardiovascular diseases for breast cancer cohort in the All of Us Research Program
Authors: Yang Han , Zhou Sicheng , Rao Zexi , Zhao Chen , Cui Erjia , Shenoy Chetan , Blaes Anne H , Paidimukkala Nishitha , Wang Jinhua , Hou Jue , Zhang Rui 
Published: July 2024

Abstract

Objective
This study leverages the rich diversity of the All of Us Research Program (All of Us)’s dataset to devise a predictive model for cardiovascular disease (CVD) in breast cancer (BC) survivors. Central to this endeavor is the creation of a robust data integration pipeline that synthesizes electronic health records (EHRs), patient surveys, and genomic data, while upholding fairness across demographic variables.

Materials and Methods
We have developed a universal data wrangling pipeline to process and merge heterogeneous data sources of the All of Us dataset, address missingness and variance in data, and align disparate data modalities into a coherent framework for analysis. Utilizing a composite feature set including EHR, lifestyle, and social determinants of health (SDoH) data, we then employed Adaptive Lasso and Random Forest regression models to predict 6 CVD outcomes. The models were evaluated using the c-index and time-dependent Area Under the Receiver Operating Characteristic Curve over a 10-year period.

Results
The Adaptive Lasso model showed consistent performance across most CVD outcomes, while the Random Forest model excelled particularly in predicting outcomes like transient ischemic attack when incorporating the full multi-model feature set. Feature importance analysis revealed age and previous coronary events as dominant predictors across CVD outcomes, with SDoH clustering labels highlighting the nuanced impact of social factors.

Discussion
The development of both Cox-based predictive model and Random Forest Regression model represents the extensive application of the All of Us, in integrating EHR and patient surveys to enhance precision medicine. And the inclusion of SDoH clustering labels revealed the significant impact of sociobehavioral factors on patient outcomes, emphasizing the importance of comprehensive health determinants in predictive models. Despite these advancements, limitations include the exclusion of genetic data, broad categorization of CVD conditions, and the need for fairness analyses to ensure equitable model performance across diverse populations. Future work should refine clinical and social variable measurements, incorporate advanced imputation techniques, and explore additional predictive algorithms to enhance model precision and fairness.

Conclusion
This study demonstrates the liability of the All of Us’s diverse dataset in developing a multi-modality predictive model for CVD in BC survivors risk stratification in oncological survivorship. The data integration pipeline and subsequent predictive models establish a methodological foundation for future research into personalized healthcare.
Association between work productivity and characteristics of adults with X-linked hypophosphatemia: an analysis of the XLH disease monitoring program
Authors: Khan Aliya , Johnson Ben , Nixon Annabel , Dent Jennifer E , Li Zhiyi , Yang Erru , Williams Angela 
Published: July 2024

Abstract
X-linked hypophosphatemia (XLH) is a rare, genetic, progressive, phosphate-wasting disorder that causes skeletal morbidities, stiffness, pain, and impaired physical function. This study used baseline data from the XLH Disease Monitoring Program to evaluate relationships between work productivity and patient characteristics (demographics, medical history, patient-reported, and functional outcomes) in adults with XLH. Bivariate analysis guided the selection of variables for multivariate analysis after adjustment for multicollinearity and conceptual overlap. The analysis comprised 281 subjects (75.4% female; 80.8% from USA; median age 39.2 yr); 53.4% were employed full-time and 31.3% were not employed; 15.3% were receiving disability payments; 47.0% were taking burosumab at study entry. Most employed subjects were working full-time outside the home (69.9%) and in light or sedentary roles (59.6%). In multivariate analyses, patients with fewer orthopedic surgeries (odds ratio [OR] 0.88; 95% confidence interval [CI], 0.81–0.96; p=.002) and better Patient-Reported Outcomes Measurement Information System Physical Function scores (OR 1.08; 95% CI, 1.02–1.15; p=.013) were more likely to be in full-time employment than not employed. Younger patients (OR 0.97; 95% CI, 0.94–0.99; p=.014) and those with fewer orthopedic surgeries (OR 0.83; 95% CI, 0.73–0.95; p=.008) were more likely to be in medium than light or sedentary work. Those with worse WOMAC Pain scores were more likely to be doing heavy/very heavy than light or sedentary activity (OR 1.04; 95% CI, 1.01–1.07; p=.006). Full-time employment levels are low in adults of working age with XLH, and unemployment and disability payment rates are high, suggesting that XLH has a substantial impact on work productivity. Worse physical function and a greater number of orthopedic surgeries are associated with lower work productivity. Worse pain, higher number of orthopedic surgeries, and younger age are associated with heavier work roles; however, causality was not specifically investigated.
Numerical simulations of the acoustic and electrical properties of digital rocks based on tetrahedral unstructured mesh
Authors: Xiao Zhanshan , Zhang Haining , Wang Yi , Ni Hao , Liu Xuefeng , Zhao Jianbing , Zhang Yonghao , Zhang Chenjun , Wei Bo 
Published: July 2024

Abstract
Unconventional reservoirs typically exhibit strong heterogeneity leading to a significant scale effect in digital rock physics simulations. To ensure the reliability of the simulation results, improving computational efficiency and increasing sample sizes are crucial. In this study, we present a numerical finite element simulation method for the acoustic and electrical properties of digital rock cores based on tetrahedral unstructured meshes. We calculated the elastic moduli and electrical resistivity of the Fontainebleau sandstone digital rock samples. A comparison was made between the tetrahedral mesh and the traditional voxel-based hexahedral mesh in terms of the accuracy and efficiency of finite element numerical simulations. The results indicate that this numerical simulation method based on the tetrahedral mesh exhibits high accuracy comparable to experimental results, and its computational efficiency is significantly improved compared to the traditional hexahedral mesh method. These findings highlight the advantages of this finite element simulation method in improving the computational scale and efficiency of digital rock simulations. It effectively addresses common computational resource constraints in dealing with large-scale core systems and facilitates better integration with engineering construction, well-logging instrument simulations, and production applications.
Challenging Consent—Applicant Versus Amicus Curiae Interventions in Sexual Violence Cases in South Africa
Authors: Swemmer Sheena 
Published: July 2024

Abstract
This note presents and analyses the Centre for Applied Legal Studies’ (CALS) considerations regarding whether to intervene as an amicus curiae or a co-applicant in Embrace v. Minister of Justice and Correctional Services (Embrace), a legal case which questions the constitutionality of the mistaken belief in consent defence in relation to rape (and other sexual offences). To present CALS’ litigation considerations, which formed the decision of whether to intervene in Embrace as an amicus curiae or co-applicant, this note presents the legal context around the mistaken belief defence. It then expands on CALS’ position around the framing of mistaken belief, which differs from the two applicants in Embrace. Finally, it presents CALS’ considerations that were required around entering the Embrace case as an applicant as opposed to entering as an amicus curia. The considerations included the benefit of co-applicants to raise new legal issues, and the forms of recourse available to amici versus co-applicants, the principle of the ‘low-hanging fruits’, and finally, potential liability around costs.
Understanding UNITAD
Authors: Rensink Rowie 
Published: July 2024

Abstract
On 21 September 2017, the United Nations (UN) Security Council established the ‘United Nations Investigative Team to Promote Accountability for Crimes Committed by Da’esh/ISIL’ (UNITAD) and tasked it to collect, preserve, and store evidence of international crimes committed by the Islamic State in Iraq. The creation of UNITAD does not stand alone. Since 1963, the UN has mandated more than 80 non- or semi-judicial ad hoc ‘Investigative Mechanisms’ (IM) in response to atrocities and situations of international concern. Recently, the realm of UN investigation witnessed an ‘accountability-turn’: by lack of other criminal justice avenues, IMs are set up and mandated to gather evidence, qualify conducts, attribute responsibility and pave the way for prosecution. Ample attention has been paid to their output and impact, but how they constitute themselves as a means to their ends — how they in actual practice interpret their mandate — has been severely understudied. This study takes UNITAD as a case and explores why it is doing what it does, how it does it, and what the implications hereof can be. Based on a literature review and expert interviews, this explorative study describes the intended purpose, priorities and principles of the written mandate as agreed upon by the UN Security Council and the Government of Iraq, and analyses UNITAD’s interpretation of these parameters in practice. It concludes that UNITAD has taken a restrictive stance with respect to some aspects of the written mandate while seeking leeway with respect to others. This navigation — informed by politics, practicalities and personality — strongly implicates the prospects of transitional justice: whereas UNITAD was mandated to foster criminal accountability, it has and still can facilitate broader forms of justice too.
Personalism and Negotiation during Civil Conflicts
Authors: Cao Ruixing 
Published: July 2024

Abstract
Under what conditions do authoritarian regimes negotiate with the rebels and accept mediation during civil conflicts? While extant literature on autocracies and conflicts has demonstrated that personalist regimes are most likely to experience both interstate and civil wars, scholars have paid less attention to how civil conflicts unfold under these regimes. Meanwhile, the characteristics of the state fighting civil conflicts can profoundly influence the battlefield dynamics, the state's willingness to negotiate, and the involvement of third-party actors. However, extant research on civil war negotiation and mediation has not identified the specific types of states that engage in negotiations. Building on research in authoritarian politics and wartime negotiation, I build a theory that connects personalist regimes with negotiation and mediation during civil conflicts. I argue that personalist regimes are more likely to negotiate with the rebels due to their low military effectiveness and high level of policy flexibility. The repressive nature of personalist regimes and their lack of credibility make bilateral negotiations more difficult to occur, increasing the probability of third-party mediation. Using comprehensive data on authoritarian regimes and civil war negotiations, this article finds support for these arguments.
Bargaining (in)visibility: Rohingya refugees and the politics of visibility in India
Authors: Mitra Rohini , Şahin-Mencütek Zeynep 
Published: July 2024

Abstract
Despite relatively low numbers, Rohingya refugees in India have faced a spiralling, multi-factorial crisis of negative visibility over the past decade, constructed by public opinion, politicians, and media coverage. This paper examines this process of negative visibility, largely outside of the community’s control, its very real consequences, and in response, how refugees navigate within an increasingly hostile policy landscape. Relying on qualitative data collected with refugees, community leaders, and NGOs in Delhi, Jaipur, and Hyderabad (2022–23), we make three interrelated arguments. First, the visibility of the Rohingya as ‘illegal immigrants’ is driven by multiple spatial and episodic factors and actors embedded in India’s fragmented refugee governance. Second, refugees seem to adopt strategic mobilities/immobilities and pursue visibility in both mediated and coerced ways to protect themselves against the risks of negative visibility. Third, these strategies have unintended consequences for reassertion of hierarchical power relations within the community and with state authorities. Empirical evidence from the Rohingya case in India contributes to growing scholarly discussion on the co-constitutive politics of (in)visibility, (im)mobility, and fragmented refugee governance in South Asia.