bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early sedation use in critically ill mechanically ventilated patients: when less is really more
Authors: Lee Christie M , Mehta Sangeeta 
Published: November 2014

AbstractOver the last 10 years, there has been an explosion of literature surrounding sedation management for critically ill patients. The clinical target has moved away from an unconscious and immobile patient toward a goal of light or no sedation and early mobility. The move away from terms such as `sedation’ toward more patient-centered and symptom-based control of pain, anxiety, and agitation makes the management of critically ill patients more individualized and dynamic. Over-sedation has been associated with negative ICU outcomes, including longer durations of mechanical ventilation and lengths of stay, but few studies have been able to associate deep sedation with increased mortality.
Post return of spontaneous circulation factors associated with mortality in pediatric in-hospital cardiac arrest: a prospective multicenter multinational observational study
Authors: López-Herce Jesús , del Castillo Jimena , Matamoros Martha , Canadas Sonia , Rodriguez-Calvo Ana , Cecchetti Corrado , Rodríguez-Núnez Antonio , Carrillo Ángel ,   Iberoamerican Pediatric Cardiac Arrest Study Network RIBEPCI
Published: November 2014

Abstract
Introduction
Most studies have analyzed pre-arrest and resuscitation factors associated with mortality after cardiac arrest (CA) in children, but many patients that reach return of spontaneous circulation die within the next days or weeks. The objective of our study was to analyze post-return of spontaneous circulation factors associated with in-hospital mortality after cardiac arrest in children.

Methods
A prospective multicenter, multinational, observational study in 48 hospitals from 12 countries was performed. A total of 502 children aged between 1 month and 18 years with in-hospital cardiac arrest were analyzed. The primary endpoint was survival to hospital discharge. Univariate and multivariate logistic regression analyses were performed to assess the influence of each post-return of spontaneous circulation factor on mortality.

Results
Return of spontaneous circulation was achieved in 69.5% of patients; 39.2% survived to hospital discharge and 88.9% of survivors had good neurological outcome. In the univariate analysis, post- return of spontaneous circulation factors related with mortality were pH, base deficit, lactic acid, bicarbonate, FiO2, need for inotropic support, inotropic index, dose of dopamine and dobutamine at 1 hour and at 24 hours after return of spontaneous circulation as well as Pediatric Intensive Care Unit and total hospital length of stay. In the multivariate analysis factors associated with mortality at 1 hour after return of spontaneous circulation were PaCO2 < 30 mmHg and >50 mmHg, inotropic index >14 and lactic acid >5 mmol/L. Factors associated with mortality at 24 hours after return of spontaneous circulation were PaCO2 > 50 mmHg, inotropic index >14 and FiO2 ≥ 0.80.

Conclusions
Secondary in-hospital mortality among the initial survivors of CA is high. Hypoventilation, hyperventilation, FiO2 ≥ 0.80, the need for high doses of inotropic support, and high levels of lactic acid were the most important post-return of spontaneous circulation factors associated with in-hospital mortality in children in our population.
Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires’ disease
Authors: Gomez-Valero Laura , Rusniok Christophe , Rolando Monica , Neou Mario , Dervins-Ravault Delphine , Demirtas Jasmin , Rouy Zoe , Moore Robert J , Chen Honglei , Petty Nicola K , Jarraud Sophie , Etienne Jerome , Steinert Michael , Heuner Klaus , Gribaldo Simonetta , Médigue Claudine , Glöckner Gernot , Hartland Elizabeth L , Buchrieser Carmen 
Published: November 2014

Abstract
Background
The genus Legionella comprises over 60 species. However, L. pneumophila and L. longbeachae alone cause over 95% of Legionnaires’ disease. To identify the genetic bases underlying the different capacities to cause disease we sequenced and compared the genomes of L. micdadei, L. hackeliae and L. fallonii (LLAP10), which are all rarely isolated from humans.

Results
We show that these Legionella species possess different virulence capacities in amoeba and macrophages, correlating with their occurrence in humans. Our comparative analysis of 11 Legionella genomes belonging to five species reveals highly heterogeneous genome content with over 60% representing species-specific genes; these comprise a complete prophage in L. micdadei, the first ever identified in a Legionella genome. Mobile elements are abundant in Legionella genomes; many encode type IV secretion systems for conjugative transfer, pointing to their importance for adaptation of the genus. The Dot/Icm secretion system is conserved, although the core set of substrates is small, as only 24 out of over 300 described Dot/Icm effector genes are present in all Legionella species. We also identified new eukaryotic motifs including thaumatin, synaptobrevin or clathrin/coatomer adaptine like domains.

Conclusions
Legionella genomes are highly dynamic due to a large mobilome mainly comprising type IV secretion systems, while a minority of core substrates is shared among the diverse species. Eukaryotic like proteins and motifs remain a hallmark of the genus Legionella. Key factors such as proteins involved in oxygen binding, iron storage, host membrane transport and certain Dot/Icm substrates are specific features of disease-related strains.
Long-Term Outcomes in Patients With Muscle-Invasive Bladder Cancer After Selective Bladder-Preserving Combined-Modality Therapy: A Pooled Analysis of Radiation Therapy Oncology Group Protocols 8802, 8903, 9506, 9706, 9906, and 0233
Authors: Mak Raymond H. , Hunt Daniel , Shipley William U. , Efstathiou Jason A. , Tester William J. , Hagan Michael P. , Kaufman Donald S. , Heney Niall M. , Zietman Anthony L. 
Published: November 2014

Purpose Multiple prospective Radiation Therapy Oncology Group (RTOG) protocols have evaluated bladder-preserving combined-modality therapy (CMT) for muscle-invasive bladder cancer (MIBC), reserving cystectomy for salvage treatment. We performed a pooled analysis of long-term outcomes in patients with MIBC enrolled across multiple studies. Patients and Methods Four hundred sixty-eight patients with MIBC were enrolled onto six RTOG bladder-preservation studies, including five phase II studies (RTOG 8802, 9506, 9706, 9906, and 0233) and one phase III study (RTOG 8903). Overall survival (OS) was estimated using the Kaplan-Meier method, and disease-specific survival (DSS), muscle-invasive and non–muscle-invasive local failure (LF), and distant metastasis (DM) were estimated by the cumulative incidence method. Results The median age of patients was 66 years (range, 34 to 93 years), and clinical T stage was T2 in 61%, T3 in 35%, and T4a in 4% of patients. Complete response to CMT was documented in 69% of patients. With a median follow-up of 4.3 years among all patients and 7.8 years among survivors (n = 205), the 5- and 10-year OS rates were 57% and 36%, respectively, and the 5- and 10-year DSS rates were 71% and 65%, respectively. The 5- and 10-year estimates of muscle-invasive LF, non–muscle-invasive LF, and DM were 13% and 14%, 31% and 36%, and 31% and 35%, respectively. Conclusion This pooled analysis of multicenter, prospective RTOG bladder-preserving CMT protocols demonstrates long-term DSS comparable to modern immediate cystectomy studies, for patients with similarly staged MIBC. Given the low incidence of late recurrences with long-term follow-up, CMT can be considered as an alternative to radical cystectomy, especially in elderly patients not well suited for surgery.
The Use of Discriminant Analysis to Predict the Bankruptcy of Companies Listed on the NewConnect Market
Authors: Mosionek-Schweda Magdalena 
Published: November 2014

The aim of this article is to analyze and evaluate the usability of discriminant models in predicting bankruptcy for companies listed on NewConnect. This market was established in 2007 and operates as an alternative trading system next to Warsaw Stock Exchange S.A., which in practice means that its regulatory regime in relation to issuers and listed companies is not as strict as the one applicable to the main market, therefore shares of small and medium-size businesses, including start-ups, can be listed on NewConnect. In this paper, discriminant models are used to analyse the financial situation of four companies removed from trading on NewConnect due to bankruptcy, Perfect Line S.A., Promet S.A., InwazjaPC S.A. and Budostal-5 S.A. The analysis is based on three models: Altman's model for emerging markets, as well as two models of the highest predictive ability according to P. Antonowicz's research, Z7INEPAN model developed in the Polish Academy of Sciences and E. Mączyńska's model, developed by Polish scientists and adapted to the Polish economy. The results confirm that these models are a valuable tool in assessing the financial condition of enterprises and allow for bankruptcy forecasting. Their application to companies listed on NewConnect, however, may be limited due to the specific profile of these entities as most of these enterprises are in fact newly formed and therefore the existing empirical data may prove insufficient.
Is congenital talipes equinovarus a risk factor for pathological dysplasia of the hip?
Authors: Paton R. W. , Choudry Q. A. , Jugdey R. , Hughes S. 
Published: November 2014

There is controversy whether congenital foot abnormalities are true risk factors for pathological dysplasia of the hip. Previous United Kingdom screening guidelines considered congenital talipes equinovarus (CTEV) to be a risk factor for hip dysplasia, but present guidelines do not. We assessed the potential relationship between pathological dysplasia of the hip and fixed idiopathic CTEV.We present a single-centre 21-year prospective longitudinal observational study. All fixed idiopathic CTEV cases were classified (Harrold and Walker Types 1 to 3) and the hips clinically and sonographically assessed. Sonographic Graf Type III, IV and radiological irreducible hip dislocation were considered to be pathological hip dysplasia.Over 21 years there were 139 children with 199 cases of fixed idiopathic CTEV feet. Sonographically, there were 259 normal hips, 18 Graf Type II hips, 1 Graf Type III hip and 0 Graf Type IV hip. There were no cases of radiological or sonographic irreducible hip dislocation.Fixed idiopathic CTEV should not be considered as a significant risk factor for pathological hip dysplasia. This conclusion is in keeping with the current newborn and infant physical examination guidelines in which the only risk factors routinely screened are family history and breech presentation. Our findings suggest CTEV should not be considered a significant risk factor in pathological dysplasia of the hip.Cite this article: Bone Joint J 2014;96-B:1553–5.
Field testing the Unified Classification System for peri-prosthetic fractures of the pelvis and femur around a total hip replacement
Authors: Vioreanu M. H. , Parry M. C. , Haddad F. S. , Duncan C. P. 
Published: November 2014

The Unified Classification System (UCS) emphasises the key principles in the assessment and management of peri-prosthetic fractures complicating partial or total joint replacement. We tested the inter- and intra-observer agreement for the UCS as applied to the pelvis and femur using 20 examples of peri-prosthetic fracture in 17 patients. Each subtype of the UCS was represented by at least one case. Specialist orthopaedic surgeons (experts) and orthopaedic residents (pre-experts) assessed reliability on two separate occasions. For the pelvis, the UCS showed inter-observer agreement of 0.837 (95% confidence intervals (CI) 0.798 to 0.876) for the experts and 0.728 (95% CI 0.689 to 0.767) for the pre-experts. The intra-observer agreement for the experts was 0.861 (95% CI 0.760 to 0.963) and 0.803 (95% 0.688 to 0.918) for the pre-experts. For the femur, the UCS showed an inter-observer kappa value of 0.805 (95% CI 0.765 to 0.845) for the experts and a value of 0.732 (95% CI 0.690 to 0.773) for the pre-experts. The intra-observer agreement was 0.920 (95% CI 0.867 to 0.973) for the experts, and 0.772 (95% CI 0.652 to 0.892) for the pre-experts. This corresponds to a substantial and ‘almost perfect’ inter- and intra-observer agreement for the UCS for peri-prosthetic fractures of the pelvis and femur. We hope that unifying the terminology of these injuries will assist in their assessment, treatment and outcome. Cite this article: Bone Joint J 2014;96-B:1472–7.
Comparison between 28 mm and 32 mm ceramic-on-ceramic bearings in total hip replacement
Authors: Lee Y. K. , Ha Y. C. , Koo K. H. 
Published: November 2014

Large femoral heads have become popular in total hip replacement (THR) as a method of reducing the risk of dislocation. However, if large heads are used in ceramic-on-ceramic THR, the liner must be thinner, which may increase the risk of fracture. To compare the rates of ceramic fracture and dislocation between 28 mm and 32 mm ceramic heads, 120 hips in 109 patients (51 men and 58 women, mean age 49.2 years) were randomised to THR with either a 28 mm or a 32 mm ceramic articulation. A total of 57/60 hips assigned to the 28 mm group and 55/60 hips assigned to the 32 mm group were followed for at least five years. No ceramic component fractures occured in any patient in either group. There was one dislocation in the 32 mm group and none in the 28 mm group (p = 0.464). No hip had detectable wear, focal osteolysis or prosthetic loosening. In our small study the 32 mm ceramic articulation appeared to be safe in terms of ceramic liner fracture.Cite this article: Bone Joint J 2014;96-B:1459–63.
Ethics in fashion as a social problem: Ethical fashion in Poland
Authors: Raciniewska Alicja 
Published: November 2014

Abstract
At the beginning of the twenty-first century the issues concerning natural environment protection began to be associated with the concepts of social responsibility and corporate social responsibility, and the idea of sustainability has become a criterion for operation assessment and a particular meta-narrative. For over two decades these issues have now been also associated with the garment industry. Although in other western countries, these subjects have long been recognized as important social problems worth seeking solutions to, in Poland discussions regarding ethical fashion are still obscure. The subject of interest in this article is the analysis of the presence of ethical fashion in Poland and the shape of public discourse regarding this topic. The first part defines the concept of ethical fashion. The second part is devoted to a presentation of the most important entities and practices associated with ethical fashion in Poland and the attempts to establish how important these issues are for contemporary Polish people. The third part presents the results of the study on ethical fashion and its role in Polish public discourse, especially in the manners of framing and interpreting in Polish opinion-forming media the problem of the garment factory catastrophe in Bangladesh. The principal aim of the presented analysis is the attempt to provide the answer to the following question: are the issues of ethics and fashion industry responsibility perceived as a significant problem in Poland?
Spinning a sustainable yarn: Environmental sustainability and brand story in the Australian fashion industry
Authors: Payne Alice 
Published: November 2014

Abstract
In the Australian fashion industry, few fashion brands have intervened in the design of their products or the systems around their product to tackle environmental pollution and waste. Instead, support of charities (whether social or environmental) has become conflated with sustainability in the eyes of the public. Thus it is difficult to assess with any accuracy fashion brands’ response to sustainability. This article aims to address this through proposing a categorization system to structure the various interventions that a company may make. This system is applied to two case studies, analysing campaigns that respond to environmental sustainability by two established Australian brands, Country Road and Billabong. The case studies demonstrate how the interventions employed by a company, at least in the Australian context, are carefully developed to align with their brand story, revealing the interplay between the intangible aspects of a brand’s positioning and the tangible, measurable impacts of their garments.
Understanding the links between positive psychology and fashion: A grounded theory analysis
Authors: Masuch Christoph-Simon , Hefferon Kate 
Published: November 2014

Abstract
Fashion is clearly under-represented within contemporary psychology. Amongst the few empirical works that do exist, individual clothing behaviours are frequently dealt with in a context of psychological ill-being. This contradicts earlier psychological writings where clothing practices were thought to be life-affirming and well-being enhancing activities. Against this backdrop, this study explored fashion from a positive psychological perspective. Ten participants reported their subjective experience of day-to-day clothing practices in response to open-ended inquiry. Grounded theory analysis revealed that clothing practices were employed as powerful techniques to negotiate selfhood, befriend the body and manage mood. The interaction of these three processes enabled the management of everyday well-being as fashion was found to be a rich source of positivity in participants’ lives. These findings have far-reaching implications for the field of (positive) psychology, opening up a number of doors for potential future research.
From Minimalist Research to Utopian Zeal
Authors: Ružić Igor 
Published: November 2014

Abstract
Both the jury and audience of the 6th Slovenian Contemporary Dance Festival Gibanica 2013 were most impressed by the productions that the official selectors included in their programme, "A Revolt of Details". This positive reception testifies that the programming of art-even in extremely "curatorial times"-does not necessarily lead to mass ennui in its reception or effect. The article treats upon very different performances from the festival: they move on the edge of minimalism (Are Made of This, The Very Delicious Piece), through ascetic multimedia (Double), or they devote themselves to the body, addressing it through dance (Transland, Awaiting Resonance), revolt (Ballet of Revolt), personal reflection (Eden) or the leaving behind of civilization (The Other At The Same Time).
MASKA Forum: Legalisation of the Contemporary Dance Field, or Moving from Presence to Representation
Authors: Kopač Andreja , Kraigher Amelia 
Published: November 2014

Abstract
Attempting to think about the future of Slovene contemporary dance, Maska's forum took as its starting point the document prepared in 1994 by the Contemporary Dance Association Slovenia (CDAS), which states the goals and the annual plan of the association. The aim and the purpose of the forum and the follow-up discussion was to critically examine and reflect upon what points in the programme, written two decades ago, have been realised and to delineate how to think about the "future" of the abolished Center of Contemporary Dance Arts (CCDA) as the first public institution in the contemporary dance area in Slovenia - a future that never came to exist. The forum looked carefully into which plans from the 1994 document are still topical as well as ways in which to think about the future of the field that would go beyond the existing frames of cultural politics and institutional regulation of the sector. The forum enabled artists and theoreticians who have left an indelible imprint on the contemporary dance field in Slovenia to present their proposals, views and to provide insight and commentary.
Two Cultural-Historical Examples of Constructing Institutional Models in the field of Contemporary Dance and their abortive import into the Slovenian Cultural Space
Authors: Vevar Rok 
Published: November 2014

Abstract
The article consists of two parts: the first part attempts to demonstrate how the inability to cooperate and the conflicted atmosphere between Pia and Pino Mlakar and the circle of Meta Vidmar and her students was imported to Slovenia from the German dance space and is the legacy of the dissent between Rudolf Laban and Mary Wigman, who had strongly differing views on the relationship between contemporary dance and dance institutions; and the second part describes the career path of Ksenija Hribar, her work in Great Britain and the experience she gained at LCDS and LCDT, as a basis for the deviation from joint efforts in the establishment of the Contemporary Dance Association Slovenia.
Between ڪثرة and Modernity: Kuwait's Political Interventions at The Venice Biennale of Architecture
Authors: Apostolou-Hölscher Stefan 
Published: November 2014

Abstract
Following the discovery and exploitation of oil, from the 1930s onwards Kuwait City became an architectural playground. Originally designed mainly by Western visionaries in order to implant into and impose onto this part of the Gulf region what they understood by modernity and the modern craft of architecture. In 2012 Kuwait participated at the 13th International Architecture Exhibition for the first time. Under the curatorship of Zahra Ali Baba, a team of architects, sound designers and visual artists developed a contribution that was not only quite experimental but also very political. Their work sought to illustrate the multiplicity of Kuwait and soon developed into a critical investigation and re-appropriation of the ambivalent history of Kuwait City as well as the whole country in the 20th century.
From the Articulation of Problems to the Manifestative Claims for Sistemically Regulated Contemporary Dance Practices: The Contemporary Dance Association Slovenia
Authors: Vevar Rok 
Published: November 2014

Abstract
The article follows the genealogy of the Contemporary Dance Association Slovenia, whose establishment took almost 10 years (1985-1994). It draws from the documents and materials available in order to stress the changes in the thinking on contemporary dance, detect the need for the professionalisation of the field in the 1980s and observe that the circle of creators of Dance Theatre Ljubljana established the Association in 1994 without the participation of the creators of expressive dance in Slovenia.
Effect of cadmium stress on barley tissue damage
and essential metal transport into plant
Authors: Lachman Jaromír , Kotíková Zora , Zámečníková Brigita , Miholová Daniela , Száková Jiřina , Vodičková Hana 
Published: November 2014

Abstract
Conductometric assessment of electrolyte
leakage from spring barley plant organs subjected to
higher cadmium concentrations 10-2 – 10-4 mol l-1 revealed
serious tissue damage. Therefore plants were grown under
controlled environment conditions in a phytotron in Knop´s
nutrient solution in two variants – the control variant
without cadmium and experimental variant treated during
the growth of plants with CdCl2 solution of 10-5 mol l-1. Barley
plants were then separated into roots, residual caryopses,
leaf bases, and leaves. Lyophilized samples were analyzed for
the uptake and redistribution of cadmium, calcium, copper,
iron, zinc, and manganese in plant organs by spectrometric methods. Cadmium caused significant decrease of calcium
and manganese levels in all analyzed plant parts indicating
that cadmium was a distinctive antagonist to intake of these
metals. Cadmium treatment also lowered amounts of zinc
and iron in roots. An opposite trend was characteristic for Cu,
where Cd stress caused significant Cu increase and retention
in roots and significant decrease in leaves. The combined
usage of the electroanalytical technique - conductometry
and spectrometric methods (ICP-OES, AAS) proved to be a
useful tool for monitoring of tissue damage and intake and
transfer of cadmium and macro- and microelements into
barley organs.