bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile and Low‐Cost Electrochemical Synthesis of Zinc Alginate Hydrogel Films for Biomedical Applications
Authors: Rupar Jelena , Marković Mihajlo , Božić Dragana , Antić‐Stanković Jelena , Mijailović Nataša R. , Gavrilov Nemanja , Bajuk‐Bogdanović Danica , Milojević‐Rakić Maja , Janošević Ležaić Aleksandra 
Published: August 2024

ABSTRACTElectrochemical synthesis and characterization of Zn‐alginate hydrogel films and their antioxidant and antimicrobial activity are evaluated. Swelling properties, zinc concentration and spectroscopic and morphological features were characterized and related to their antimicrobial and antioxidant activity. These results indicate a dependence of swelling on the degree of cross‐linking, which, in turn, can be adjusted by manipulating the synthesis time, initial alginate concentration and/or zinc leaching. Hydrogel films with zinc showed remarkable antibacterial properties, especially against gram‐positive bacteria. The absence of Zn resulted in less inhibition of gram‐positive strains, although it had a positive effect on the inhibition of gram‐negative strains, which was attributed to the degradation of alginate chains, affecting cell metabolism. Nitrogen‐doped samples synthesized in rivanol‐containing solution exhibited globular morphology and higher antioxidant activity. The electrochemical synthesis enables the facile preparation of highly active alginate hydrogels for biomedical applications.
Extensive characterization of optimally treated Licuala grandis leaf sheath fiber for possible bio‐reinforcement in polymer composites
Authors: Selvanayagam Lillypushpam Beschi Selvan , Sagai Francis Britto Antony , Brailson Mansingh Bright , Binoj Joseph Selvi 
Published: August 2024

AbstractThe comprehensive characteristics of an ecologically viable cellulosic fiber from the leaf sheath of Licuala grandis L tree are alkaline modified and investigated in this study. The percentage of cellulose in ideally alkali‐modified Licuala grandis leaf sheath fiber (IALGLSF) increased by 15.8% following a 1 h treatment with a 5% (w/v) alkali buffer. Comparing IALGLSF to raw Licuala grandis leaf sheath fiber (LGLSF), an individual strand tensile testing revealed a 13.2% rise in tensile characteristics. Crystallinity index (CI) analysis using x‐ray diffraction (XRD) showed that IALGLSF had a 12.5% greater CI over LGLSF. Also, Fourier transform infrared spectroscopy (FTIR) experiments validated partial removal of noncrystalline constituents from IALGLSF as a consequence of alkali alteration. Additionally, thermogravimetric (TGA‐DTG) study, which is supported by differential scanning calorimetry (DSC) inquiry, demonstrated that alkali alteration‐enhanced IALGLSF's thermal resistance from 223 to 229°C. Similarly, scanning electron microscopy (SEM) has shown that rougher surface appearance of IALGLSF results from selective removal of noncrystalline constituents, which also provides better matrix contact during reinforcement for the production of eco‐friendly composites. The indicated outcomes validated that IALGLSF serves as a beneficial substitute for potentially harmful synthetic fibers in the production of sustainable biocomposites.
Removal of Acid Orange 7 dye using Makgeolli lees with ultrasonic assistance
Authors: Van Kien Nguyen , Kim Sunghwan , Ryoo Jae Jeong 
Published: August 2024

AbstractThis study investigated the efficient removal of Acid Orange 7 (AO7) dye in water by using Makgeolli lees, a popular by‐product obtained during the production of traditional Makgeolli beverages in Korea. By incorporating ultrasound, the effects of contact time, Makgeolli lees dosage, initial AO7 dye concentration, and initial pH of the dye solution were investigated and comprehensively compared with the same experiment using the stirring method. The results consistently showed ultrasound not only enhances the excellent adsorption ability of Makgeolli lees but also accelerates the process compared to the stirring method. The Langmuir isotherm model best described the adsorption process for both methods, suggesting monolayer adsorption on the surface of Makgeolli lees, with maximum capacities of 25.13 mg/g for ultrasound at 40 kHz and 20.41 mg/g for stirring methods. Furthermore, the study showed that optimal dye removal efficiency can be achieved with ultrasound conditions at 28 kHz frequency, 125 W/L power density, and 100% ultrasound intensity. This research promises that the integration of low‐cost biomass coupled with ultrasound could provide a potential solution for dye wastewater treatment.
Distinct latitudinal patterns of shifting spring phenology across the Appalachian Trail Corridor
Authors: Tourville Jordon C. , Murray Georgia L. D. , Nelson Sarah J. 
Published: August 2024

AbstractWarming associated with climate change will advance the onset of spring phenology for many forest plants across the Eastern United States. Understory forbs and spring ephemerals that fix a disproportionate amount of carbon during early spring may be negatively affected by earlier canopy closure; however, information on the spatial patterns of phenological change for these communities is still lacking. To assess the potential for changes in spring phenological windows, we synthesized observations from the Appalachian Mountain Club's (AMCs) Mountain Watch (MW) project, the National Phenology Network (NPN), and AMC's iNaturalist projects between 2004 and 2022 (n = 118,250) across the length of the Appalachian Trail (AT) Corridor (34° N–46° N latitude). We used hierarchical Bayesian modeling to examine the sensitivity of spring flowering and leaf‐out for 11 understory species and 14 canopy tree species to mean spring temperature (April–June). We conducted analyses across the AT Corridor, partitioned by regions of 4° latitude (south, mid‐Atlantic, and north). Spring phenologies for both understory plants and canopy trees advanced with warming (~6 and ~3 days/°C, respectively). However, the sensitivity of each group varied by latitude, with the phenology of trees and understory plants advancing to a greater degree in the mid‐Atlantic region (~10 days/°C) than in the southern or northern regions (~5 days/°C). While we find evidence that phenological windows remain stable in the southern and mid‐Atlantic portions of the AT, we observed an expansion of the spring phenological window in the north where there was greater understory forb temperature sensitivity compared with trees (~2.7 days/°C). Our analyses indicate the differential sensitivity of forest plant phenology to potential warming across a large latitudinal gradient in the Eastern United States. Further, evidence for a temperature‐driven expansion of the spring phenological window suggests a potential beneficial effect for understory plants in the northern AT, although phenological mismatch with potential pollinators and increased vulnerability to late winter frosts are possible. Using extensive citizen‐science datasets allows us to synthesize regional‐ and continental‐scale data to explore spatial and temporal trends in spring phenology related to warming. Such data can help to standardize approaches in phenological research and its application to forest climate resiliency.
AOP Report: An Upstream Network for Reduced Androgen Signaling Leading to Altered Gene Expression of Androgen Receptor–Responsive Genes in Target Tissues
Authors: Draskau Monica K. , Rosenmai Anna K. , Bouftas Nora , Johansson Hanna K. L. , Panagiotou Eleftheria M. , Holmer Marie L. , Elmelund Emilie , Zilliacus Johanna , Beronius Anna , Damdimopoulou Pauliina , van Duursen Majorie , Svingen Terje 
Published: August 2024

Abstract
Adverse outcome pathways (AOPs) can aid with chemical risk assessment by providing plausible links between chemical activity at the molecular level and effect outcomes in intact organisms. Because AOPs can be used to infer causality between upstream and downstream events in toxicological pathways, the AOP framework can also facilitate increased uptake of alternative methods and new approach methodologies to help inform hazard identification. However, a prevailing challenge is the limited number of fully developed and endorsed AOPs, primarily due to the substantial amount of work required by AOP developers and reviewers. Consequently, a more pragmatic approach to AOP development has been proposed where smaller units of knowledge are developed and reviewed independent of full AOPs. In this context, we have developed an upstream network comprising key events (KEs) and KE relationships related to decreased androgen signaling, converging at a nodal KE that can branch out to numerous adverse outcomes (AOs) relevant to androgen-sensitive toxicological pathways. Androgen signaling represents an extensively studied pathway for endocrine disruption. It is linked to numerous disease outcomes and can be affected by many different endocrine-disrupting chemicals. Still, pathways related to disrupted androgen signaling remain underrepresented in the AOP-wiki, and endorsed AOPs are lacking. Given the pivotal role of androgen signaling in development and function across vertebrate taxa and life stages of both sexes, this upstream AOP network serves as a foundational element for developing numerous AOPs. By connecting the upstream network with various downstream AOs, encompassing different species, it can also facilitate cross-species extrapolations for hazard and risk assessment of chemicals. Environ Toxicol Chem 2024;43:2329–2337. © 2024 The Author(s). Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
Alleviating hedonic adaptation in repeat consumption with creative thinking
Authors: You Yanfen (Cindy) , Wang Lili , Yang Xiaojing , Wen Na 
Published: August 2024

AbstractRepeat consumption, a common aspect of consumers' daily lives, often results in hedonic adaptation such as satiation or boredom. In line with a growing body of research exploring methods to alleviate hedonic adaptation, this research proposes and finds that creative thinking can effectively reduce hedonic adaptation. Through five experiments conducted across various consumption contexts (music listening, video watching, photograph viewing, snack eating), we show that creative thinking reduces hedonic adaptation by fostering cognitive flexibility during repeat consumption (e.g., enjoying the same photograph from different aspects across repetitions). Supporting this underlying mechanism, the mitigating effect of creative thinking on hedonic adaptation attenuates when consumers' cognitive flexibility is constrained, or when the product itself possesses sufficient complexity that naturally encourages cognitive flexibility over repetitions. Overall, this research sheds light on how creative thinking helps alleviate hedonic adaptation in repeat consumption, with implications for marketing managers and practitioners.
Inpatients' understanding of the hospitalist role and common medical terminology
Authors: Curatola Nicole , Juergens Nathan , Atkinson Mariam K. , Schnipper Jeffrey L. , Weiss Rachel , Cohen Erin Y. , Cimino Jenica , To Clara , Bambury Elizabeth A. , Barkoudah Ebrahim , Mani Sampathkumar , Khalil Hassan , Mora Rosa , Maru Johsias , Harrison James D. 
Published: August 2024

AbstractMany patients are unable to identify members of their hospital care team and experience confusion regarding some medical terminology used during hospitalization, including descriptions of the structure of their inpatient care team. This cross‐sectional study sought to (1) examine inpatients' understanding of the role of a hospitalist and (2) assess inpatients' familiarity with other medical terminology commonly used in the hospital. We surveyed 172 patients admitted to the hospital medicine service at two academic medical centers. We found that almost half (47%) of respondents were unfamiliar with the term and/or role of a hospitalist, while the remaining patients had varied understanding of the role. Several other medical terms were frequently misunderstood (such as “NPO,” “PA,” and “Attending”). Ongoing efforts are needed to improve communication to ensure that hospitalized patients understand the hospitalist's role and the medical terms shared with them.
Quantitative Analysis of Small Intestinal Motility in 3D Cine‐MRI Using Centerline‐Aware Motion Estimation
Authors: van Harten Louis D. , de Jonge Catharina S. , Struik Femke , Stoker Jaap , Išgum Ivana 
Published: August 2024

BackgroundCurrently available tools for noninvasive motility quantification of the small intestine are limited to dynamic 2D MRI scans, which are limited in their ability to differentiate between types of intestinal motility.PurposeTo develop a method for quantification and characterization of small intestinal motility in 3D, capable of differentiating motile, non‐motile and peristaltic motion patterns.Study TypeProspective.SubjectsFourteen healthy volunteers (127 small intestinal segments) and 10 patients with Crohn's disease (87 small intestinal segments).Field Strength/Sequence3.0 T, 3D balanced fast field echo sequence, 1 volume per second.AssessmentUsing deformable image registration between subsequent volumes, the local velocity within the intestinal lumen was quantified. Average velocity and average absolute velocity along intestinal segments were used with linear classifiers to differentiate motile from non‐motile intestines, as well as erratic motility from peristalsis. The mean absolute velocity of small intestinal content was compared between healthy volunteers and Crohn's disease patients, and the discriminative power of the proposed motility metrics for detecting motility and peristalsis was determined. The consensus of two observers was used as referenced standard.Statistical TestsStudent's t‐test to assess differences between groups; area under the receiver operating characteristic curve (AUC) to assess discriminative ability. P < 0.001 was considered significant.ResultsA significant difference in the absolute velocity of intestinal content between Crohn's patients and healthy volunteers was observed (median [IQR] 1.06 [0.61, 1.56] mm/s vs. 1.84 [1.37, 2.43] mm/s), which was consistent with manual reference annotations of motile activity. The proposed method had a strong discriminative performance for detecting non‐motile intestines (AUC 0.97) and discernible peristalsis (AUC 0.81).Data ConclusionAnalysis of 3D cine‐MRI using centerline‐aware motion estimation has the potential to allow noninvasive characterization of small intestinal motility and peristaltic motion in 3D.Evidence Level3Technical EfficacyStage 2
Numerical solution of fractal‐fractional differential equations system via Vieta‐Fibonacci polynomials fractal‐fractional integral operators
Authors: Rahimkhani Parisa , Ordokhani Yadollah , Sabermahani Sedigheh 
Published: August 2024

AbstractThe main idea of this work is to present a numerical method based on Vieta‐Fibonacci polynomials (VFPs) for finding approximate solutions of fractal‐fractional (FF) pantograph differential equations and a system of differential equations. Although the presented scheme can be applied to any fractional integral, we focus on the Caputo, Atangana‐Baleanu, and Caputo‐Fabrizio integrals with due to their privileges. To carry out the method, first, we introduce FF integral operators in the Caputo, Atangana‐Baleanu, and Caputo‐Fabrizio senses. Then, by applying the Vieta‐Fibonacci polynomials and their FF integral operators together with the collocation method, the problem becomes reduced to a system of algebraic equations that can be solved by Mathematical software. In the presented scheme, acceptable approximate solutions are achieved by employing only a few number of the basic functions. Moreover, the error analysis of the presented method is investigated. Finally, the accuracy of the presented method is examined through the numerical examples. The proposed scheme is implemented for some famous systems of FF differential equations, such as memristor, which is a fundamental circuit element so called universal charge‐controlled mem‐element, convective fluid motion in rotating cavity, and Lorenz chaotic system.
Cloning, purification, and functional characterization of recombinant pullulanase from Bacillus cereusATCC 14579 for improved detergent performance
Authors: Zafar Asma , Masood Ammara , Rahman Ziaur , Hamid Attia , Javed Mah Hoor , Zulfiqar Amna , Fatima Samreen , Makhdoom Madood , Aftab Muhammad Nauman 
Published: August 2024

AbstractThe present study outlines the approach that was employed for cloning, expression, and characterization of the recombinant pullulanase enzyme from Bacillus cereus ATCC 14579 into Escherichia coli BL21(DE3) using pET‐25b (+) expression vector. The recombinant pullulanase enzyme was purified using ammonium sulfate precipitation and immobilized metal ion affinity chromatography (IMAC). The molecular mass of the purified pullulanase enzyme was measured using sodium dodecyl sulfate‐polyacrylamide gel electrophoresis (SDS‐PAGE) as 95 kDa. The purified recombinant pullulanase enzyme demonstrated significant thermal stability, maintaining its structural integrity and functionality at temperatures as high as 90°C over a period of 4 h. The inclusion of divalent metal ions, specifically Ca2+ and Mg2+, had a positive effect on the activity of the pullulanase enzyme. Conversely, the presence of Co2+ and EDTA (Ethylene Diamine Tetra Acetic acid) resulted in suppression of the enzyme activity. The purified pullulanase enzyme demonstrated remarkable resistance when exposed to organic solvents. The enzyme activity was notably decreased in the presence of SDS (Sodium Dodecyl Sulfate) while β‐mercaptoethanol and tween‐60 did not substantially affect the enzyme activity and stability which suggest its potential applicability in the detergent sector. This discovery indicates a potential approach to improve the effectiveness of currently available detergents in the marketplace.
What I was thinking/what I would do differently: Biological markers and mechanisms of mental health
Authors: Andero Raül , Jovanovic Tanja , Stein Murray B. , Shalev Arieh Y. 
Published: August 2024

AbstractAt the 39th meeting of the International Society of Traumatic Stress Studies, four leading scientists and clinicians were invited to reflect on their careers, focusing on the biological mechanisms and markers of traumatic stress. Dr. Raul Andero has contributed to understanding how stress alters memory networks in the brain, influencing the development of novel treatments. Dr. Tanja Jovanovic has pioneered the measurement and mechanistic understanding of fear learning, bridging basic and clinical research. Dr. Murray B. Stein has scaled up clinical and lab observations to large populations, refining the field's understanding of traumatic stress. Dr. Arieh Y Shalev has shaped the definition of traumatic stress, pioneering the longitudinal investigation of stress and integrating advanced computational methods to identify individuals at risk. These panelists were asked to reflect on their initial problems, ambitions, concerns, and unexpected challenges, as well as the influence of their work, on new research trajectories. Their insights provide valuable lessons about the process and content of their work, and their pioneering efforts have significantly advanced our understanding of the biological mechanisms and markers of traumatic stress.
Poly(ethylene‐glycol)‐Dimethacrylate (PEGDMA) Composite for Stereolithographic Bioprinting
Authors: Chang Shu‐Yung , Lee Joseph Zhi Wei , Sargur Ranganath Anupama , Ching Terry , Hashimoto Michinao 
Published: August 2024

AbstractRecent progress in additive manufacturing has enabled the application of stereolithography (SLA) in bioprinting to produce 3D biomimetic structures. Bioinks for SLA often require synthetic polymers as supplements to ensure the structural integrity of the printed cell‐laden constructs. High molecular weight (MW) poly(ethylene‐glycol)‐diacrylate (PEGDA) (MW ≥ 3400 Da) is commonly used to enhance the mechanical property of crosslinked hydrogels. However, the production of bioink with high MW PEGDA requires in‐house polymer synthesis or the acquisition of costly reagents, which may not be readily available in all laboratory settings. As an alternative to high MW PEGDA, this research investigated the use of poly(ethylene‐glycol)‐dimethacrylate (PEGDMA) (MW = 1000 Da) as a supplement of a bioink to enhance the mechanical properties of the SLA‐printed constructs. The successful demonstration showcases 1) the fabrication of 3D constructs with overhang and complex architecture, and 2) the cytocompatibility, with high cell viability of 71–87% over 6 days of culture, of the GelMA‐PEGDMA bioink to enable cell‐laden bioprinting. This study suggests PEGDMA as a viable supplement in the formulation of SLA bioink. The accessibility to PEGDMA will facilitate the advance in 3D bioprinting to fabricate complex bioinspired structures and tissue surrogates for biomedical applications.
Green IT: The Evolution of Environmental Concerns Within ICT Policy, Research and Practice
Authors: Fors Per , Kreps David , O’Brien Ann 
Published: August 2024

AbstractThis chapter delves into the environmental concerns associated with Information and Communications Technology (ICT) along its value chain, understood as the series of activities that need to be undertaken to produce, use and dispose of ICT. These activities have their respective challenges in terms of environmental sustainability, including greenhouse gas (GHG) emissions, pollution and waste. Furthermore, the chapter offers an overview of practices and discourses, particularly within the realm of information systems (IS), since the 1960s and onwards. It traces the evolution of the Green IT, a concept that originated in response to mounting environmental concerns and the widespread integration of ICT into various facets of society around the mid-2000s. The chapter explores the translation of Green IT, which was mainly concerned with the negative environmental impact of ICT, into Sustainable ICT, a broader concept imbued with more optimistic narratives about the environmental impact of ICT. Drawing from this extensive review, the chapter highlights emerging issues, such as the energy consumption of ICT with the advent of AI and cryptocurrencies, and a growing emphasis on repair and refurbishment. The authors then interpret the interest in these emerging issues as a renewed focus on mitigating the negative impacts of ICT within Sustainable ICT.
Integrating Digital and Sustainability Transformation Through Artificial Intelligence: A Framework for AI-enabled Twin Transformation
Authors: Crome Carlotta , Graf-Drasch Valerie , Oberländer Anna Maria , Seidel Stefan 
Published: August 2024

Abstract“Twin Transformation” is characterised by synergistic leveraging of efforts towards digital and sustainability transformation. It relies on digital transformation to develop digital solutions that can improve sustainability and on sustainability transformation to provide the goals and insights that are required to design these digital solutions. This integrated approach uses data streams and the predictive and generative capabilities of systems enabled by Artificial Intelligence (AI). These systems help to overcome the boundaries of human rationality in addressing the complex problem space that exists at the intersection of digital and sustainability transformation. This chapter provides a framework for AI-enabled Twin Transformation and calls for a joint discourse to master what are arguably the two key transformations of this and the following decades.