bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delayed responses and extinction debt: an opportunity for the conservation of Chaco Serrano forest birds
Authors: Silvetti L. E. , Gavier Pizarro G. , Arcamone J. R. , Bellis L. M. 
Published: August 2024

AbstractLand‐use change is one of the main threats to biodiversity at the global level, and subtropical dry forests are not exempt from such a threat. Recent studies suggest that species can become extinct with a considerable time lag, even if no further habitat loss occurs. Hence, there may be an extinction debt, which poses a great challenge to conservation. Here, we analyzed the response of taxonomic and functional richness of forest and understory specialist birds to 30 years (data from 1989, 2004 and 2019) of land‐cover and land‐use changes in the Chaco Serrano forest of central Argentina. Our results showed the occurrence of extinction debt in both forest and understory specialist birds, with such debt being greater in forest specialist birds. Results for species trait debt were inconclusive. We also found evidence that birds are not equally sensitive to land‐use change, indicating a species‐specific response. We conclude that the current presence of some large native forest patches and an intermediate degree of isolation in the region might be prolonging the persistence of some bird species and traits. Moreover, ecological legacies can strongly affect the current species distribution pattern and the permanence of functional traits in fragmented landscapes. These findings should be considered in conservation planning.
Myopia dominance in preterm infants without and with retinopathy of prematurity: Indian Twin Cities ROP study (ITCROPS) report number 15
Authors: Thakur Swapnil , Kumari Seema , Sanghavi Vishwa , Belenje Akash , Bhate Manjushree , Ranjan Padhi Tapas , Jalali Subhadra , Verkicharla Pavan K. 
Published: August 2024

AbstractPurposeTo investigate the refractive error profile and progression in infants with different stages of ROP, without ROP, and those who received laser treatment for ROP.MethodsThis retrospective study included the data from 838 infants (baseline mean age 3.7 ± 5.4 months) who had premature birth. Among these, 433 infants had one of the stages of ROP and 405 had no ROP. Infants with ROP were sub‐divided into stage 1 (n = 76), stage 2 (n = 142), and stage 3 (n = 136) and aggressive posterior ROP, (APROP, n = 79). They were further categorized into those who received treatment (n = 213) and with no treatment for ROP (n = 220). Data from a subset of 117 infants was used to assess the 1‐year change in the refractive error. Myopia was defined as spherical equivalent refraction (SER) <−0.50 diopters (D). Eyes with retinal detachment were excluded.ResultsHigher percentage of myopia was found in infants with ROP (39.7%) than no‐ROP (19.8%), and it increased with severity of ROP: stage 1: 19.7%, stage 2: 33.8%, stage 3: 45.6%, and 59.5% in APROP. Percentage of myopia doubled in those who underwent treatment for ROP (54.5%) compared to no‐treatment group (25.5%). Mean (± SEM) change in SER after 1 year was significantly greater in infants with APROP −4.55 ± 1.38 D and stage 3 ROP −2.28 ± 0.57 D compared to other stages and no‐ROP.ConclusionMyopia was found to be more prevalent in preterm infants in general, and more in the presence of ROP. Preterm infants without or with any form of ROP, particularly those with severe form of ROP and those who received treatment require meticulous periodic refractive error assessment.
Beneficial effects of MGL‐3196 and BAM15 combination in a mouse model of fatty liver disease
Authors: Zhou Mingyan , Li Catherine , Byrne Frances L. , Vancuylenburg Calum S. , Olzomer Ellen M. , Hargreaves Adam , Wu Lindsay E. , Shackel Nicholas A. , Santos Webster L. , Hoehn Kyle L. 
Published: August 2024

AbstractBackground and AimMetabolic dysfunction‐associated steatohepatitis (MASH) is a metabolic disorder with limited treatment options. The thyroid hormone receptor (THR)‐β agonist resmetirom/MGL‐3196 (MGL) increases liver fat oxidation and has been approved for treating adult MASH. However, over 60% of patients receiving MGL treatment do not achieve MASH resolution. Therefore, we investigated the potential for combination therapy of MGL with the mitochondrial uncoupler BAM15 to improve fatty liver disease outcomes in the GAN mouse model of MASH.MethodsC57BL/6J male mice were fed GAN diet for 38 weeks before stratification and randomization to treatments including MGL, BAM15, MGL + BAM15, or no drug control for 8 weeks. Treatments were admixed in diet and mice were pair‐fed to control for drug intake. Treatment effectiveness was assessed by body weight, body composition, energy expenditure, glucose tolerance, tissue lipid content, and histological analyses.ResultsMGL + BAM15 treatment resulted in better efficacy versus GAN control mice than either monotherapy in the context of energy expenditure, liver fat loss, glucose control, and fatty liver disease activity score. Improvements in ALT, liver mass, and plasma cholesterol were primarily driven by MGL, while improvements in body fat were primarily driven by BAM15. No treatments altered liver fibrosis.ConclusionsMGL + BAM15 treatment had overall better efficacy to improve metabolic outcomes in mice fed GAN diet than either monotherapy alone. These data warrant further investigation into combination therapies of THR‐β agonists and mitochondrial uncouplers for the potential treatment of disorders related to fatty liver, obesity, and insulin resistance.
Managerial decision horizon and corporate greenwashing: Evidence from China
Authors: Yu Jinyue , Qiu Qiang , Qiao Yuyang 
Published: August 2024

AbstractCorporate greenwashing, a significant manifestation of the decoupling of corporate social responsibility, has attracted considerable attention from stakeholders. Based on the internal governance theory, this study examines listed Chinese companies from 2011 to 2021 to assess the effects of managerial decision horizons on corporate greenwashing behaviours. Our finding shows that a shorter managerial decision horizon exacerbates corporate greenwashing. The robustness of the result has been verified by employing various methods, including the use of instrumental variables, the two‐stage Heckman model and alternative variable substitution. Additionally, the study reveals the mechanisms underlying this phenomenon and identifies reduced environmental investment as one of the channels through which myopic managerial decision‐making enhances corporate greenwashing. The results also indicate that financial constraints on firms intensify the impact of managerial myopia on greenwashing, whereas the proportion of female executives and investors' site visits mitigate this effect. This study presents important implications for stakeholders governing corporate greenwashing by elucidating the relationship between managerial decision horizons and greenwashing.
Aquatic invasive species exhibit contrasting seasonal detectability patterns based on environmental DNA: Implications for monitoring
Authors: Rounds Christopher I. , Arnold Todd W. , Chun Chan Lan , Dumke Josh , Totsch Anna , Keppers Adelle , Edblad Katarina , García Samantha M. , Larson Eric R. , Nelson Jenna K. R. , Hansen Gretchen J. A. 
Published: August 2024

Abstract

Aquatic invasive species (AIS) are a global threat to freshwater biodiversity and ecosystem services. Documenting AIS prevalence at broad spatial scales is critical to effective management and early detection. However, conventional monitoring for AIS is costly and is rarely applied at the resolution and scale required for effective management. Monitoring of AIS using environmental DNA (eDNA) has the potential to enable broadscale surveillance at a fraction of the cost of conventional methods, but key questions must first be addressed related to how eDNA detection probability varies among environments, seasons, and multiple species with different life histories.

To quantify spatiotemporal variation in the detection probability of AIS using eDNA sampling, we surveyed 20 lakes with known populations of four aquatic invasive species: common carp (Cyprinus carpio), rusty crayfish (Faxonius rusticus), spiny waterflea (Bythotrephes longimanus), and zebra mussels (Dreissena polymorpha). We collected water samples at 10 locations per lake, five times throughout the open water season resulting in a total of 1,000 water samples. Quantitative polymerase chain reaction was used with species‐specific assays to determine the presence of each species' eDNA in water samples. With Bayesian occupancy models, we quantified the effects of lake and site characteristics and Julian date on eDNA detection probability.

The probability of eDNA detection varied seasonally, and the seasonal variation was species‐specific and related to species life histories. Zebra mussel eDNA was generally the most detectable among the species we targeted, and detection probability peaked in midsummer when only six water samples were required to achieve a 95% probability of detection (80% Bayesian credible interval: 3–12 samples). Spiny waterflea eDNA detections also peaked in mid to late summer, but were overall the most difficult species to detect, requiring 160 samples for a 95% probability of detection (80% Bayesian credible interval: 67–1,616 samples). Common carp eDNA was most detectable in the spring and rusty crayfish eDNA was most detectable in the early autumn, corresponding to key life history events.

Sampling for eDNA during the optimal time of the year for each species decreased the number of samples required to reach a 95% probability of detection by an order of magnitude or more.

Our results are relevant for decision makers interested in using eDNA as a multi‐species monitoring tool and highlight the importance of life history in the efficacy of eDNA monitoring.
Where to go: Factors influencing Hong Kong university students' attitude towards working in the Greater Bay Area
Authors: Wu Fengyu , Jung Jisun 
Published: August 2024

AbstractThis study explores Hong Kong university students' concerns when making employment decisions after graduation and their attitudes towards working in mainland China, especially in the Greater Bay Area (GBA). Two research questions were identified: What are Hong Kong students' attitudes towards working in the GBA? What factors influence Hong Kong students' employment choices? A qualitative research approach was adopted with semi‐structured interviews with 38 final‐year students from eight Hong Kong universities. Based on thematic analysis, the findings showed that Hong Kong university students' willingness to work in the GBA was mainly influenced by their previous connections with the destination and potential career development opportunities. However, Shenzhen was the only city out of nine in the GBA they considered for employment. University students were aware of the economic rationale for their employment preparation, but, more importantly, they placed a high value on professional development opportunities and work–life balance. They also valued opportunities for internationalisation and emphasised the importance of the work culture and environment in choosing employment. The findings have policy implications for graduate employment and the intra‐mobility of talented young people across GBA cities in China.
Production and characterisation of antioxidant and antibacterial polymeric nanoparticles loaded with Oenocarpus bataua phenolic extract
Authors: Ferreira Richard D. R. , Paula Ladyslene C. , Sora Gisele T. S. , Bernardo Ricardo A. , Cruz Maurício V. , Leles Maria Inês G. , Fernandes Kátia F. , Batista Karla A. 
Published: August 2024

SummaryOne recent trend in the food industry is using natural antioxidants and antimicrobials as additives for developing multi‐functional packaging. In this study, phenolic compounds from patawa (PEP), a neglected Amazon palm tree, were extracted and encapsulated in nanoparticles based on acetylated cashew gum polysaccharide (acCGP) and chitosan (CS) using a nanoprecipitation technique. The primary objective was to evaluate the antioxidant activity and antibacterial properties of PEP and acCGP/CS@PEP. Results from HPLC‐MS showed that PEP is mainly composed of epicatechin, naringenin and rutin. acCGP/CS@PEP nanoparticles showed a spheric and smooth microstructure, observed with 40.1% PEP encapsulation into the nanoparticles. The main encapsulated phenolics were luteolin, quercetin and epicatechin. Also, FTIR spectroscopy, X‐ray diffraction and differential scanning calorimetry analyses evidenced the success of PEP encapsulation. Results from antioxidant activity evidenced that acCGP/CS@PEP has a DPPH scavenging activity 45‐fold higher than the unencapsulated PEP, a 5‐fold higher ferric reducing power and 20‐fold higher antioxidant potential against ABTS. Similarly, acCGP/CS@PEP had higher antibacterial activity against Escherichia coli (MIC = 2.24 mg mL−1), Salmonella enteritis (MIC = 4.48 mg mL−1) and Staphylococcus aureus (MIC = 4.48 mg mL−1). Analysis by SEM evidenced that acCGP/CS@PEP had a potent destructive effect with disruption of the bacterial cell membrane and liberation of cytoplasmic content. These findings demonstrated that PEP could be efficiently encapsulated in acCGP/CS nanoparticles, and this strategy could improve the efficiency of PEP as a bioactive compound for developing active packaging.
Comprehensive analysis of targeted phenolic, sugar, and amino acid variation in 10‐day‐old wheatgrass in response to temperature and photoperiod
Authors: Kumar Arun , Singh Narpinder 
Published: August 2024

SummaryThe present study investigated the phenolic profile, sugar composition and amino acid profile of lyophilised 10‐day‐old wheatgrass cultivated under varying temperature and photoperiod conditions. The targeted phenolic profile showed the abundant presence of chlorogenic, caffeic, ferulic and p‐coumaric acid. The phenolic content varied with temperature and photoperiod conditions. The comprehensive sugar profile indicated the variation in the concentration of glucose with different growing conditions altered carbohydrate metabolism in wheatgrass. Similarly, the concentration of amino acids also varied with growing conditions. Notably, the concentration of proline, arginine and GABA in wheatgrass from all wheat varieties increased more prominently in photoperiod of 22 h and growth temperature of 22 °C in light and 17 °C in dark as a response of defence mechanism.
Comparison of vegetable powders as ingredients of flatbreads: technological and nutritional properties
Authors: Santamaria Maria , Ruiz Maria , Garzon Raquel , Rosell Cristina M. 
Published: August 2024

SummaryHealth‐driven innovation is transforming bakery products, particularly with non‐conventional ingredients. This study aimed to produce healthy and technologically acceptable flatbreads, exploring the inclusion (2%) of vegetable powders (black and green olives, orange peel, lemon, tomato, beetroot, carrot, onion, artichoke, spinach, chard, kale and pak choi). Spinach and chard increased the mineral content (1.42 and 1.30 g/ 100 g) respect to control (1.01 g/100 g). Fibre content ranged from 9.33 to 11.18 g/100 g when added onion, chard, pak choi, tomato or artichoke. Beetroot was the most effective changing the colour (ΔE* 43.09), while tomato reduced the hardness (4.06 vs 5.29 N in the control). Lemon and tomato were effective reducing the extent of starch enzymatic hydrolysis by 65% and 34%, respectively. Vegetable powders can be innovative, natural, sustainable and healthy ingredients in the breadmaking of flatbreads. The incorporation of these non‐conventional ingredients opens new opportunities for the bakery industry.
The emergence of training programmes for the garment industry: Analysing the cases of Bangladesh, Cambodia and Sri Lanka from a historical‐institutionalist perspective
Authors: Maurer Markus , Shimu Sheikh Shahana , Veung Naron 
Published: August 2024

AbstractThis study analyses industry‐specific training programmes catering to the garment industry in Bangladesh, Cambodia and Sri Lanka. Employing a historical‐institutionalist perspective and using mainly qualitative data, it focuses on programmes that are considered particularly relevant by the industry and discuss their characteristics as well as factors that have had an impact on their development. The article finds that such programmes are usually offered beyond formal upper secondary vocational education and training, mostly at postsecondary and tertiary level, and in many cases by private providers. However, the case of Sri Lanka shows that public investment in the training of employees at different skill levels can make an important contribution to the development of a high‐skill formation regime—but that it depends on the right timing.
Describing a programme of implementation‐effectiveness research on the organization and implementation of frontline nursing care delivery into diverse health systems
Authors: Bender Miriam , Williams Marjory (Micki) 
Published: August 2024

AbstractAimsThe longitudinal programme of research described in this paper seeks to generate knowledge about factors influencing the implementation of a system‐level intervention, the clinical nurse leader care model, involving nurses as leaders at the frontlines of care and the outcomes achievable with successful implementation. The research programme has the following aims, (a) to clarify clinical nurse leader practice, (b) develop and empirically validate a translational model of frontline care delivery that includes clinical nurse leader practice and (c) delineate the patterns of and critical outcomes of successful implementation of the clinical nurse leader care model.DesignThis programme of research follows a knowledge‐building trajectory involving multiple study designs in both qualitative (grounded theory, case study) and quantitative (descriptive, correlational and quasi‐experimental) traditions.MethodsMultiple mixed methods within a system‐based participatory framework were used to conduct this programme of implementation–effectiveness research.ResultsFindings are demonstrating how the clinical nurse leader care model, as a complex system‐level intervention, can be implemented in diverse healthcare contexts to make a difference to patient care quality and safety. Findings also contribute to implementation science, helping to better understand the dynamic interdependencies between implementation, the interventions implemented and the contexts in which they are implemented.ConclusionFindings translate into sets of evidence‐informed implementation ‘recipes’ that health systems can match to their specific contexts and needs. This allows health systems to take on strategies that both maximize resource impact within their existing structures and support achieving intended outcomes.ImplicationThis programme of research is producing actionable implementation and outcome evidence about ways to organize nursing knowledge and practice into care models that can be successfully adopted within real‐world healthcare settings to achieve safer and higher quality patient care.
Identification of molecular targets and small drug candidates for Huntington's disease via bioinformatics and a network‐based screening approach
Authors: Hossain Md Ridoy , Tareq Md. Mohaimenul Islam , Biswas Partha , Tauhida Sadia Jannat , Bibi Shabana , Zilani Md. Nazmul Hasan , Albadrani Ghadeer M. , Al‐Ghadi Muath Q. , Abdel‐Daim Mohamed M. , Hasan Md. Nazmul 
Published: August 2024

AbstractHuntington's disease (HD) is a gradually severe neurodegenerative ailment characterised by an increase of a specific trinucleotide repeat sequence (cytosine–adenine–guanine, CAG). It is passed down as a dominant characteristic that worsens over time, creating a significant risk. Despite being monogenetic, the underlying mechanisms as well as biomarkers remain poorly understood. Furthermore, early detection of HD is challenging, and the available diagnostic procedures have low precision and accuracy. The research was conducted to provide knowledge of the biomarkers, pathways and therapeutic targets involved in the molecular processes of HD using informatic based analysis and applying network‐based systems biology approaches. The gene expression profile datasets GSE97100 and GSE74201 relevant to HD were studied. As a consequence, 46 differentially expressed genes (DEGs) were identified. 10 hub genes (TPM1, EIF2S3, CCN2, ACTN1, ACTG2, CCN1, CSRP1, EIF1AX, BEX2 and TCEAL5) were further differentiated in the protein–protein interaction (PPI) network. These hub genes were typically down‐regulated. Additionally, DEGs‐transcription factors (TFs) connections (e.g. GATA2, YY1 and FOXC1), DEG‐microRNA (miRNA) interactions (e.g. hsa‐miR‐124‐3p and has‐miR‐26b‐5p) were also comprehensively forecast. Additionally, related gene ontology concepts (e.g. sequence‐specific DNA binding and TF activity) connected to DEGs in HD were identified using gene set enrichment analysis (GSEA). Finally, in silico drug design was employed to find candidate drugs for the treatment HD, and while the possible modest therapeutic compounds (e.g. cortistatin A, 13,16‐Epoxy‐25‐hydroxy‐17‐cheilanthen‐19,25‐olide, Hecogenin) against HD were expected. Consequently, the results from this study may give researchers useful resources for the experimental validation of Huntington's diagnosis and therapeutic approaches.
Emerging connectivity of programmed cell death pathways and pulmonary vascular remodelling during pulmonary hypertension
Authors: Yuan Meng‐nan , Liu Ting , Cai An‐qi , Zhan Zibo , Cheng Yi‐li , Wang Qi‐yue , Xia Yu‐xuan , Shen Nong‐er , Huang Ping , Zou Xiao‐zhou 
Published: August 2024

AbstractPulmonary hypertension (PH) is a chronic progressive vascular disease characterized by abnormal pulmonary vascular resistance and pulmonary artery pressure. The major structural alteration during PH is pulmonary vascular remodelling, which is mainly caused by the imbalance between proliferation and apoptosis of pulmonary vascular cells. Previously, it was thought that apoptosis was the only type of programmed cell death (PCD). Soon afterward, other types of PCD have been identified, including autophagy, pyroptosis, ferroptosis and necroptosis. In this review, we summarize the role of the above five forms of PCD in mediating pulmonary vascular remodelling, and discuss their guiding significance for PH treatment. The current review could provide a better understanding of the correlation between PCD and pulmonary vascular remodelling, contributing to identify new PCD‐associated drug targets for PH.
FBXO22 promotes osteosarcoma progression via regulation of FOXO1 for ubiquitination and degradation
Authors: Zhang He , Bai Yang , Li Jiatong , Chen Ting , Shang Guanning 
Published: August 2024

AbstractAccumulating evidence has demonstrated that F‐box protein 22 (FBXO22) participates in tumour development and progression in various types of human malignancies. However, the functions and detailed molecular mechanisms of FBXO22 in osteosarcoma tumorigenesis and progression remain elusive. In this study, we aimed to determine the effects of FBXO22 on the cell proliferation, migration and invasion of osteosarcoma cells using cell counting kit‐8 and Matrigel Transwell approaches. Moreover, we explored the molecular mechanisms by which FBXO22 mediated oncogenesis and progression in osteosarcoma via Western blotting, immunoprecipitation and ubiquitination. We found that FBXO22 depletion inhibited the proliferation, migration and invasion of osteosarcoma cells, whereas FBXO22 overexpression increased the proliferation and motility of osteosarcoma cells. Mechanistically, FBXO22 promoted the ubiquitination and degradation of FoxO1 in osteosarcoma cells. FBXO22 depletion reduced cell proliferation and motility via regulation of FoxO1. Taken together, our findings provide new insight into FBXO22‐induced osteosarcoma tumorigenesis. The inhibition of FBXO22 could be a promising strategy for the treatment of osteosarcoma.