bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiomics analysis of canine myocardium after circumferential pulmonary vein ablation: Effect of neuropeptide Y on long‐term reinduction of atrial fibrillation
Authors: Song Qiyuan , Zhang Ning , Zhang Yujiao , Zhang An , Li Huilin , Bai Shuting , Shang Luxiang , Du Juanjuan , Hou Yinglong 
Published: August 2024

AbstractCatheter ablation (CA) is an essential method for the interventional treatment of atrial fibrillation (AF), and it is very important to reduce long‐term recurrence after CA. The mechanism of recurrence after CA is still unclear. We established a long‐term model of beagle canines after circumferential pulmonary vein ablation (CPVA). The transcriptome and proteome were obtained using high‐throughput sequencing and TMT‐tagged LC‐MS/LC analysis, respectively. Differentially expressed genes and proteins were screened and enriched, and the effect of fibrosis was found and verified in tissues. A downregulated protein, neuropeptide Y (NPY), was selected for validation and the results suggest that NPY may play a role in the long‐term reinduction of AF after CPVA. Then, the molecular mechanism of NPY was further investigated. The results showed that the atrial effective refractory period (AERP) was shortened and fibrosis was increased after CPVA. Atrial myocyte apoptosis was alleviated by NPY intervention, and Akt activation was inhibited in cardiac fibroblasts. These results suggest that long‐term suppression of NPY after CPVA may lead to induction of AF through promoting cardiomyocyte apoptosis and activating the Akt pathway in cardiac fibroblasts, which may make AF more likely to reinduce.
Transgovernmental Labour Standards Enforcement in a Pan‐European Labour Market: An Arms Race Between Institutional Alignment and Regulatory Arbitrage
Authors: Lillie Nathan , Brzozowska Anita , Kall Kairit , Salamońska Justyna , Matuszczyk Kamil 
Published: August 2024

AbstractTransgovernmental co‐operation is an important European Union (EU) regulatory method, but it imposes transaction costs on the organizations involved. Regulatory requirements under conditions of European free movement drive transgovernmentalism, but transaction costs also shape transgovernmental regulation and regulatory outcomes. We investigate co‐operation around labour standards regulation for posted construction workers, focusing on bilateral co‐operation of labour inspectorates between Estonia and Finland and comparing it with co‐operation efforts between Poland and Finland, and Ukraine via Poland to Finland. The shifting patterns of labour mobility and employer efforts to recruit from less regulated sources mean that investment in bilateral relations can be undermined by the dynamic character of the pan‐European labour market. This article contributes to debates on EU regulatory governance by showing how transaction costs from co‐operation can decrease the effectiveness of transgovernmental network‐based governance; in the case of labour regulation, employers exploit this to undermine the effectiveness of labour inspection co‐operation.
Development and validation of the eMCI‐CHD tool: A multivariable prediction model for the risk of mild cognitive impairment in patients with coronary heart disease
Authors: Wang Qing , Liu Yanfei , Xu Shihan , Liu Fenglan , Huang Luqi , Xu Fengqin , Liu Yue 
Published: August 2024

AbstractObjectiveThis study aimed to develop and validate an eMCI‐CHD tool based on clinical data to predict mild cognitive impairment (MCI) risk in patients with coronary heart disease (CHD).MethodsThis cross‐sectional study prospectively collected data from 400 patients with coronary heart disease (aged 55–90 years, 62% men) from July 2022 to September 2023 and randomized (7:3 ratio) them into training and validation sets. After determining the modeling variables through least absolute shrinkage and selection operator regression analysis, four ML classifiers were developed: logistic regression, extreme gradient boosting (XGBoost), support vector machine, and random forest. The performance of the models was evaluated using area under the ROC curve, accuracy, sensitivity, specificity, and F1 score. Decision curve analysis was used to assess the clinical performance of the established models. The SHapley Additive exPlanations (SHAP) method was applied to determine the significance of the features, the predictive model was visualized with a nomogram, and an online web‐based calculator for predicting CHD‐MCI risk scores was developed.ResultsOf 400 CHD patients (average age 70.86 ± 8.74 years), 220 (55%) had MCI. The XGBoost model demonstrated superior performance (AUC: 0.86, accuracy: 78.57%, sensitivity: 0.74, specificity: 0.84, F1: 0.79) and underwent validation. An online tool (https://mr.cscps.com.cn/mci/index.html) with seven predictive variables (APOE gene typing, age, education, TyG index, NT‐proBNP, C‐reactive protein, and occupation) assessed MCI risk in CHD patients.ConclusionThis study highlights the potential for predicting MCI risk among CHD patients using an ML model‐driven nomogram and risk scoring tool based on clinical data.
Toxicological assessment of a novel spiro‐derivative, 4‐amino‐1‐azaspiro[4.5]dec‐3‐en‐2‐one for the greater wax moth, Galleria mellonella
Authors: Abdel Hafez Mogeda M. , Ali Jamin , Khan Khalid Ali , Ghramh Hamed A. , Fekry Reda M. , El‐Gendy Rehab M. 
Published: August 2024

AbstractThe greater wax moth, Galleria mellonella L., poses a substantial threat to apiculture, adversely impacting wax quality and potentially acting as a disease vector. There is an urgent need to develop innovative and effective control strategies to address the challenges posed by this pest and ensure the sustainability of the apiculture industry. Spiro‐derivative compounds represent a novel class of environmentally safe compounds with high insecticidal properties. For example, they have demonstrated high efficacy against sap‐sucking insects such as aphids and whiteflies. However, their effect on chewing insects has not yet been well explored. In this study, we hypothesized that 4‐amino‐1‐azaspiro[4.5]dec‐3‐en‐2‐one (4A1AD), a spiro‐derivative compound, would exhibit efficacy against G. mellonella larvae. To test this hypothesis, we conducted dipping and feeding bioassays, incorporating varying concentrations of 4A1AD on fourth instar G. mellonella larvae, and recorded mortality, biochemical parameters including total soluble protein content and enzyme activities, and anatomical abnormalities resulting from treatment. Results revealed a significant increase in larval mortality with increased concentrations and treatment durations across both bioassays. Additionally, a significant decrease in protein content and an increase in phenol‐oxidase activity were observed with alterations in α and β‐esterase activities. Scanning electron microscope findings revealed abnormalities in larval cuticle, spiracular openings and legs. These findings demonstrated the efficacy of 4A1AD, indicating a potential alternative to conventional insecticides in promoting sustainable apiculture practices. Moreover, they provide valuable contributions to the development of novel strategies for effective pest management in apicultural settings.
Public Discourse on the Israel‐Hamas War 2023: A Comparative Analysis of Lithuania and the United Kingdom
Authors: Sutkutė Rūta 
Published: August 2024

AbstractThe conflict between the Israeli government and Hamas escalated on 7th October 2023, with the media playing an unprecedented role in shaping the perceptions and narratives surrounding the ongoing tensions. The portrayal by the media, often mirroring global viewpoints and biases, has significantly influenced public opinion and international stances, serving as a catalyst for political, diplomatic, and humanitarian interventions. The aim of the study is to analyze the formation of discourse on the Israel‐Hamas war (2023) within the media landscapes of Lithuania and the United Kingdom, emphasizing the role of national broadcasters and uncovering the primary disparities in the information provided by online news portals lrt.lt and bbc.com. Employing the qualitative content analysis method, the study provides comprehensive insights into the subject matter. Moreover, it highlights the approaches of the Lithuanian and UK governments towards security discourse in Europe and their concerns regarding humanitarian aid for the Gaza Strip. The study is relevant to shed light on how political decisions and public opinion influence the international community's support for various actors in the conflict, including the manifestation of Islamophobic and antisemitic sentiments.
Making “Enemies”: Industry‐State Subterfuge and US Fair Trade Practices Towards Non‐Market Economies Since 1960
Authors: Bassney John P. 
Published: August 2024

AbstractStudies on US “non‐market economy” (NME) antidumping (AD) policy frame its origins as either an ideological relic of the Cold War or as a case of regulatory capture informed by strategic filing patterns. While these insights are invaluable, they do not address the underlying social processes which inform the creation of economic concepts in the first instance. NME policy evolved out of the legal‐discursive tactics employed by the US steel industry hoping to receive relief from imports, and a US state which had to simultaneously provide a form of protection to the steel industry and maintain an international commitment to free trade. Steel and the state used legal subterfuge to achieve these goals. Accordingly, NME policy developed from the institutional struggle between two stakeholders in a strategic action field.
Reverse scan body: Complete digital workflow for double full‐arch zirconia prostheses
Authors: Papaspyridakos Panos , Castellanos Lina , Bedrossian E. Armand , Romeo Davide , Kudara Yukio , Chochlidakis Konstantinos 
Published: August 2024

AbstractDuring intraoral complete‐arch digital implant scanning, one of the most technique‐sensitive steps is the implant data acquisition and merging of different surface geometry data sets for prototype prosthesis fabrication due to the absence of fixed landmarks. Recently developed extraoral techniques have allowed for an alternative approach for the digital acquisition of implant position in completely edentulous patients. Specifically, extraoral digital scanning of the conversion prosthesis after connecting reverse scan bodies has been proposed as an efficient approach. The reverse scan body protocol digitally simulates the traditional back‐pouring technique long utilized in analog workflows. The present article describes a technique for simplifying the digital workflow for the fabrication of passive‐fitting definitive prostheses using the reverse scan body concept.
Development and Initial Validation of the Death Attitudes in Relationships Scale
Authors: Kawashima Daisuke , Kempe Tomomi , Koga Yoshiki , Kubota Sayaka , Tsujimoto Tai , Urata Yu , Watanabe Terumi , Kondo‐Arita Megumi 
Published: August 2024

AbstractRelationships with close relatives, friends, and future generations should be critical in a collective society; therefore, the fear of separation from others, and care for others, must be core components of attitudes concerning death. However, such relational attitudes toward death have been insufficiently investigated. This study develops a new psychological scale for assessing death attitudes considering relationships with loved ones and future generations. In Study 1, we conducted an exploratory factor analysis using data from 477 Japanese adults. The results revealed a five‐factor structure of the Death Attitudes in Relationships Scale (DARS) and confirmed its internal consistency, convergent validity, and test–retest reliability. In Study 2 (N = 380), we demonstrated the goodness‐of‐fit indices for the factor structure and further verified the construct validity, considering relationships with other variables. As such, we confirmed the validity and reliability of the DARS. The DARS can be used to reexamine the previous, accumulated findings using the existing scale.
The Effect of Coaches' Interpersonal Style Profiles on Young Athletes' Motivation and Sport Commitment
Authors: Mohebi Mahmoud , Zarei Sahar , Zandi Hassan Gharayagh , Bahrami Alireza 
Published: August 2024

AbstractThe objective of this study was to identify both the latent profiles of coaching styles based on athletes' perceptions and their subsequent associations with athletes' motivation and sport commitment. The sample comprised young athletes from various sports types. Participants provided self‐reports of their perceptions of their coaches' behaviors, and their sport commitment and sport motivation. Cluster analyses revealed three coaching style profiles: Cluster 1 were coaches with a “low coaching style,” including those who lacked an autonomy‐supportive and those with a low controlling coaching style. Cluster 2 was labeled “Supportive coaching style” and represented coaches who were more apt to be autonomy‐supportive and less controlling. Cluster 3 was a “Controlling coaching style” and included coaches who demonstrated a low autonomy‐supportive and a high controlling style. Compared with athletes in Cluster 3, athletes in Clusters 1 and 2 reported higher levels of adaptive motivation and commitment variables. Thus, youth athletes perceived three clusters of coaching styles (Low coaching style, Supportive coaching style, and Controlling coaching style), and these profiles were associated with varying levels of athletes' motivation and commitment to sport.
Replicating Camera Perspective Bias in the Japanese Justice System
Authors: Tanda Tomoyuki , Naka Makiko , Kawahara Jun‐Ichiro 
Published: August 2024

AbstractThe camera perspective of recorded video interrogations has been shown to influence judgments concerning confession voluntariness; this is a phenomenon known as camera perspective bias (CPB), originally reported by Lassiter and Irvine (1986). When comparing perspectives where the suspect is visible (suspect‐focused), the detective is visible (detective‐focused), and both are visible (equal‐focused), the perceived voluntariness of a confession was greatest under the suspect‐focused condition and lowest under the detective‐focused condition. However, research conducted under the Japanese recording style by Nakata et al. (2018), using a dual‐presentation format, yielded inconsistent results, possibly because of insufficient statistical power. To address this issue, our study investigated the occurrence of CPB under the Japanese recording style with sufficient power. In Experiment 1, we aimed to replicate Nakata et al.'s (2018) study using the same mock interrogation materials. In Experiment 2, we aimed to replicate the original study conducted under the Japanese recording style. However, we did not find any evidence supporting the presence of CPB. These results suggest that CPB may not be robust, at least under the Japanese recording style.
A rapid manual technique does not have adequate sensitivity and specificity to reliably discriminate between neutropenic and non‐neutropenic dogs prior to administration of chemotherapy
Authors: Walton‐Clark M. , Henriques T. , Best M. 
Published: August 2024

ObjectivesTo develop and determine the accuracy of a rapid manual technique for the detection of pre‐treatment neutropenia (<1.50 × 109/L) in dogs receiving chemotherapy.Materials and MethodsTwenty canine blood smears with known neutrophil counts between 1.00 × 109/L and 3.00 × 109/L were reviewed by two internal medicine clinicians and linear regressions performed to determine a cut‐off value for a manual neutrophil count equating to >1.50 × 109/L. Consecutive blood samples from dogs undergoing chemotherapy were processed through an automated haematology analyser (VetScan HM5, Abaxis), and prospective blinded manual review by the same two observers assessed whether the manual technique could accurately detect dogs with neutropenia.ResultsLinear regression analysis found a cut‐off of >26 neutrophils per 10 low power fields at the monolayer to be equivalent to a neutrophil count of >1.5 × 109/L. A total of 183 blood samples from 43 dogs were reviewed. Automated techniques detected neutropenia in 16 of 183 (9%) blood samples. Using the manual cut‐off technique, 13 of 16 (81%) and 11 of 16 (69%) of neutropenic samples were correctly identified by observer 1 and observer 2, respectively. Twenty‐three of 167 non‐neutropenic dogs (14%) were incorrectly classified as neutropenic by observer 1, and 27 (16%) by observer 2. Inter‐observer agreement was 92%. Sensitivity was 81% (95% confidence interval 54% to 96%) for observer 1 and 69% (95% confidence interval 41% to 89%) for observer 2. Specificity was 86% (95% confidence interval 80% to 91%) for observer 1 and 84% (95% confidence interval 77% to 89%) for observer 2.Clinical SignificanceManual estimation resulted in up to five of 16 (31%) neutropenic samples being incorrectly classified. A full automated differential cell count remains preferable.
Tribological properties of real foods using extended Stribeck curves and their relationship with nutritional and rheological parameters
Authors: Hong Jung Sun , Kim Mi‐Ran , Choi Yoo Jeong , Lee In‐Young , Chun Yong Gi , Jang Hae Won , Kim Bum‐Keun 
Published: August 2024

AbstractThe tribological properties of 19 commercial food products, grouped into six categories (yogurt, dressings, spreads, porridges, emulsified sauces, and syrups) were investigated in relation to their rheological (dynamic oscillatory shear test) and nutritional properties (fat, carbohydrate, and protein). A tribological system (a glass ball and three polydimethylsiloxane pins) generated the extended Stribeck curve, monitoring friction factors (f) over an extended range of sliding speed (v) (10−8 to 100 m/s). Tribological parameters (f, v) at four inflection points dividing the frictional regimes (X1, breakaway point between the static and kinetic regimes; X1–X2, boundary; X2–X3, mixed; X3–X4, hydrodynamic regimes) and the slope between X3 and X4 (s) were subjected to principal component analysis and hierarchical clustering on principal components, using rheological and nutritional parameters as quantitative supplementary variables. Tribological patterns were predominantly influenced by viscosity, viscoelasticity, yield stress, fat content, and the presence of particles (e.g., sugar, proteins, and fibers) and pasting materials (e.g., starches and modified starches). The 19 tribological patterns were classified into 3 clusters: low f and s for fat‐ and/or viscoelastic‐dominant foods (Cluster 1), low f and high s for food emulsions and/or those with low extent of shear‐thinning (Cluster 2), and high f at the boundary regime either for the most viscous foods or for those in the presence of particulates (Cluster 3). These results suggest that the compositional and rheological properties have a more profound impact on the classification of complex tribological patterns than the categories of food products.
Outcome prediction in metabolic dysfunction‐associated steatotic liver disease using stain‐free digital pathological assessment
Authors: Kendall Timothy J. , Chng Elaine , Ren Yayun , Tai Dean , Ho Gideon , Fallowfield Jonathan A. 
Published: August 2024

AbstractComputational quantification reduces observer‐related variability in histological assessment of metabolic dysfunction‐associated steatotic liver disease (MASLD). We undertook stain‐free imaging using the SteatoSITE resource to generate tools directly predictive of clinical outcomes. Unstained liver biopsy sections (n = 452) were imaged using second‐harmonic generation/two‐photon excitation fluorescence (TPEF) microscopy, and all‐cause mortality and hepatic decompensation indices constructed. The mortality index had greater predictive power for all‐cause mortality (index >.14 vs. </=.14, HR 4.49, p = .003) than the non‐alcoholic steatohepatitis‐Clinical Research Network (NASH‐CRN) (hazard ratio (HR) 3.41, 95% confidence intervals (CI) 1.43–8.15, p = .003) and qFibrosis stage (HR 3.07, 95% CI 1.30–7.26, p = .007). The decompensation index had greater predictive power for decompensation events (index >.31 vs. </=.31, HR 5.96, p < .001) than the NASH‐CRN (HR 3.65, 95% CI 1.81–7.35, p < .001) or qFibrosis stage (HR 3.59, 95% CI 1.79–7.20, p < .001). These tools directly predict hard endpoints in MASLD, without relying on ordinal fibrosis scores as a surrogate, and demonstrate predictive value at least equivalent to traditional or computational ordinal fibrosis scores.
Genomic, morphological and physiological data support fast ecotypic differentiation and incipient speciation in an alpine diving beetle
Authors: Pallarés Susana , Ortego Joaquín , Carbonell José Antonio , Franco‐Fuentes Eduardo , Bilton David T. , Millán Andrés , Abellán Pedro 
Published: August 2024

AbstractAn intricate interplay between evolutionary and demographic processes has frequently resulted in complex patterns of genetic and phenotypic diversity in alpine lineages, posing serious challenges to species delimitation and biodiversity conservation planning. Here we integrate genomic data, geometric morphometric analyses and thermal tolerance experiments to explore the role of Pleistocene climatic changes and adaptation to alpine environments on patterns of genomic and phenotypic variation in diving beetles from the taxonomically complex Agabus bipustulatus species group. Genetic structure and phylogenomic analyses revealed the presence of three geographically cohesive lineages, two representing trans‐Palearctic and Iberian populations of the elevation‐generalist A. bipustulatus and another corresponding to the strictly‐alpine A. nevadensis, a narrow‐range endemic taxon from the Sierra Nevada mountain range in southeastern Iberia. The best‐supported model of lineage divergence, along with the existence of pervasive genetic introgression and admixture in secondary contact zones, is consistent with a scenario of population isolation and connectivity linked to Quaternary climatic oscillations. Our results suggest that A. nevadensis is an alpine ecotype of A. bipustulatus, whose genotypic, morphological and physiological differentiation likely resulted from an interplay between population isolation and local altitudinal adaptation. Remarkably, within the Iberian Peninsula, such ecotypic differentiation is unique to Sierra Nevada populations and has not been replicated in other alpine populations of A. bipustulatus. Collectively, our study supports fast ecotypic differentiation and incipient speciation processes within the study complex and points to Pleistocene glaciations and local adaptation along elevational gradients as key drivers of biodiversity generation in alpine environments.