bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kostenvergleich der konservativen vs. operativen Therapie des chronischen Lymphödems
Authors: Nuwayhid Rima , Langer Stefan , von Dercks Nikolaus 
Published: June 2024

Zusammenfassung

Hintergrund
Die Therapie des Lymphödems erfolgt primär konservativ mittels komplexer physikalischer Entstauungstherapie (KPE). Lymphovenöse Anastomosen (LVA), vaskularisierte Lymphknotentransplantationen (VLNT) und Liposuktionen stehen als operative Therapieverfahren zur Verfügung. Die Vergütung im DRG(„diagnosis related groups“)-System ist jedoch teils unzureichend oder nur nach individuellem Kostenübernahmeantrag möglich. Dabei sind die Kosten der verhältnismäßig neuen operativen Verfahren noch nicht in Relation zu denen der KPE gesetzt worden.

Methodik
Die Kosten der leitliniengemäßen konservativen Therapie wurden ermittelt. Die Kosten für LVA, VLNT und Liposuktion jeweils an oberer und unterer Extremität wurden anhand der DRG-Fallpauschalen sowie der nach aktuellem Kenntnisstand erwarteten Reduktion konservativer Maßnahmen geschätzt. Anschließend erfolgte ein Vergleich der jährlichen Therapiekosten.

Ergebnisse
Die jährlichen Therapiekosten nach LVA und VLNT sind bereits im 2. postoperativen Jahr niedriger als bei konservativer Therapie allein. Die Liposuktion erreicht diesen Punkt im 6. (obere Extremität) bzw. 47. postoperativen Jahr (untere Extremität).

Diskussion
Die Evidenz für die positiven Effekte der Lymphchirurgie ist noch begrenzt. Es ist jedoch erkennbar, dass der kurative operative Ansatz sowohl die Therapiekosten deutlich senken als auch die Lebensqualität Betroffener verbessern kann. Es mangelt jedoch an einer adäquaten Abbildung des operativen Aufwands in der Vergütung.
Assessment of the effectiveness of high-pressure water jet machining generated using self-excited pulsating heads
Authors: Szada-Borzyszkowska Monika , Kacalak Wojciech , Banaszek Kamil , Pude Frank , Perec Andrzej , Wegener Konrad , Królczyk Grzegorz 
Published: June 2024

AbstractThe article presents the research findings on the process of machining with a pulsating water jet. The study determined the influence of water velocity and pressure, providing insights into the dynamics of pulsating water jets. An evaluation of the generation process of pulsating water jets was conducted for various models of self-excited pulsating heads. The aim was to determine the impact of geometric parameters of the self-excited pulsating head and hydrodynamic working conditions on the performance of such a head, the dynamic characteristics of the water jet it produces, and its technological suitability for material erosion. In the first stage, simulation studies were carried out for three models of self-excited pulsating heads. Based on these studies, a solution with appropriate geometry was selected. Subsequently, experimental studies were conducted using the self-excited head and dedicated research setups. For the selected solution of the self-excited pulsating head, pulse durations, jet thrust forces, and frequency variations for different working pressure values were determined. The analysis showed a correlation between the geometric parameters of the head, pressure changes, and the characteristics of the generated pulses in the pulsed water jets. Pulse generation was made possible by increasing the water flow through side openings. Pulses with greater water volume exhibited increased erosive potential, particularly noticeable at higher pressures. It was found that pressure changes also affect the pulse frequency, with shorter intervals observed at lower pressures and longer intervals at higher pressures. The results presented in the paper highlight the importance of tool geometry and changes in water pressure at the inlet to the self-excited pulsating heads and the dynamics of the pulsed water jet. Research on the pulse generation mechanism and the assessment of erosive potential can form the basis for optimizing the design and operation of pulsating water jets in surface machining. This comprehensive understanding underpins the enhancement of efficiency and effectiveness of pulsating water jet applications in various industrial and manufacturing processes.
Proteomic features of gray matter layers and superficial white matter of the rhesus monkey neocortex: comparison of prefrontal area 46 and occipital area 17
Authors: Castro-Mendoza Paola B. , Weaver Christina M. , Chang Wayne , Medalla Maria , Rockland Kathleen S. , Lowery Lisa , McDonough Elizabeth , Varghese Merina , Hof Patrick R. , Meyer Dan E. , Luebke Jennifer I. 
Published: June 2024

AbstractIn this novel large-scale multiplexed immunofluorescence study we comprehensively characterized and compared layer-specific proteomic features within regions of interest of the widely divergent dorsolateral prefrontal cortex (A46) and primary visual cortex (A17) of adult rhesus monkeys. Twenty-eight markers were imaged in rounds of sequential staining, and their spatial distribution precisely quantified within gray matter layers and superficial white matter. Cells were classified as neurons, astrocytes, oligodendrocytes, microglia, or endothelial cells. The distribution of fibers and blood vessels were assessed by quantification of staining intensity across regions of interest. This method revealed multivariate similarities and differences between layers and areas. Protein expression in neurons was the strongest determinant of both laminar and regional differences, whereas protein expression in glia was more important for intra-areal laminar distinctions. Among specific results, we observed a lower glia-to-neuron ratio in A17 than in A46 and the pan-neuronal markers HuD and NeuN were differentially distributed in both brain areas with a lower intensity of NeuN in layers 4 and 5 of A17 compared to A46 and other A17 layers. Astrocytes and oligodendrocytes exhibited distinct marker-specific laminar distributions that differed between regions; notably, there was a high proportion of ALDH1L1-expressing astrocytes and of oligodendrocyte markers in layer 4 of A17. The many nuanced differences in protein expression between layers and regions observed here highlight the need for direct assessment of proteins, in addition to RNA expression, and set the stage for future protein-focused studies of these and other brain regions in normal and pathological conditions.
Predatory mites as potential biological control agents for tomato russet mite and powdery mildew on tomato
Authors: Marcossi Ítalo , Francesco Leonardo S. , Fonseca Morgana M. , Pallini Angelo , Groot Thomas , De Vis Raf , Janssen Arne 
Published: June 2024

AbstractTomato plants are attacked by numerous pests and diseases, including the tomato russet mite Aculops lycopersici and powdery mildew, Oidium neolycopersici. Natural enemies of tomato pests are often hindered by the tomato trichomes, while russet mites live under and among these leaf hairs and are therefore protected from these enemies. To find natural enemies that are adapted to tomato and its trichomes, we collected a predatory mite, Amblyseius herbicolus, and an iolinid mite, cf. Homeopronematus anconai sp. nov., from tomato plants in the field. We investigated their potential as biological control agents for pests in this crop. We show that both predators were able to feed and reproduce on russet mites. Subsequently, we show that the iolinid effectively controlled tomato russet mites and powdery mildew on isolated tomato plants, whereas A. herbicolus disappeared from the plants. Altogether, our results show that cf. H. anconai sp. nov. is an efficient biocontrol agent of two key pests on tomato plants. Our results thus contribute to the recent trend of using predators that are effective in controlling both a pest and a pathogen, a promising new strategy for biological crop protection.
Computational approaches identify a transcriptomic fingerprint of drug-induced structural cardiotoxicity
Authors: Au Yeung Victoria P.W. , Obrezanova Olga , Zhou Jiarui , Yang Hongbin , Bowen Tara J. , Ivanov Delyan , Saffadi Izzy , Carter Alfie S. , Subramanian Vigneshwari , Dillmann Inken , Hall Andrew , Corrigan Adam , Viant Mark R. , Pointon Amy 
Published: June 2024

AbstractStructural cardiotoxicity (SCT) presents a high-impact risk that is poorly tolerated in drug discovery unless significant benefit is anticipated. Therefore, we aimed to improve the mechanistic understanding of SCT. First, we combined machine learning methods with a modified calcium transient assay in human-induced pluripotent stem cell-derived cardiomyocytes to identify nine parameters that could predict SCT. Next, we applied transcriptomic profiling to human cardiac microtissues exposed to structural and non-structural cardiotoxins. Fifty-two genes expressed across the three main cell types in the heart (cardiomyocytes, endothelial cells, and fibroblasts) were prioritised in differential expression and network clustering analyses and could be linked to known mechanisms of SCT. This transcriptomic fingerprint may prove useful for generating strategies to mitigate SCT risk in early drug discovery.
Graphical Abstract
Epiretinal membranes in patients with uveitis: an update on the current state of management
Authors: Kalogeropoulos Dimitrios , Lotery Andrew John , Gupta Bhaskar , Lash Stephen , Antonakis Serafeim 
Published: June 2024

Abstract
Purpose
This review aims to summarize the current knowledge concerning the clinical features, diagnostic work-up, and therapeutic approach of uveitic epiretinal membranes (ERM).

Methods
A thorough investigation of the literature was conducted using the PubMed database. Additionally, a complementary search was carried out on Google Scholar to ensure the inclusion of all relevant items in the collection.

Results
ERM is an abnormal layer at the vitreoretinal interface, resulting from myofibroblastic cell proliferation along the inner surface of the central retina, causing visual impairment. Known by various names, ERM has diverse causes, including idiopathic or secondary factors, with ophthalmic imaging techniques like OCT improving detection. In uveitis, ERM occurrence is common, and surgical intervention involves pars plana vitrectomy with ERM peeling, although debates persist on optimal approaches.

Conclusions
Histopathological studies and OCT advancements improved ERM understanding, revealing a diverse group of diseases without a unified model. Consensus supports surgery for uveitic ERM in progressive cases, but variability requires careful consideration and effective inflammation management. OCT biomarkers, deep learning, and surgical advances may enhance outcomes, and medical interventions and robotics show promise for early ERM intervention.
Terahertz RCS reduction employing reconfigurable graphene-based AMC structures
Authors: Gaber Shaymaa M. , Ibrahim Ahmed A. 
Published: June 2024

AbstractRecently, modern technology has towards stealth technology, especially in military applications so, this paper presents a terahertz radar cross-section (RCS) reduction utilizing reconfigurable graphene-based artificial magnetic conductor (AMC) arrays. The AMC unit cell has a Vivaldi shape with circular slots etched in the radiator to reduce the RCS from metallic surfaces at THz bands. The AMC cells affect the surface impedance of the metallic objects which reduces the reflected EM waves from them. The RCS reduction bandwidth is achieved and controlled by varying the voltage applied to graphene cells which varies its chemical potential (µc). The effect of changing the graphene conductivity on the RCS reduction is investigated. Different arrangements to obtain maximum RCS reduction are presented. A 12 × 12 hybrid arrangement of the graphene-based AMC structures achieved maximum RCS reduction from 1.5 to 4 THz with 22 dB greater than the unloaded metallic surface. The CST simulator is employed in the simulation.
Revealing the structure of combinative research design and performance in an operations management context
Authors: Curado Carla , Oliveira Mírian , Teixeira Eduardo Kunzel , Schniederjans Dara 
Published: June 2024

AbstractThis study defines the conceptual structure of combinative research design in operations management by relying on several proxies of combinative research topics, methods, and author affiliations, covering a decade of research and analyzing 1026 bibliographic records in an applied social science research context. Through the use of bibliometrics, co-word analyses are conducted to compute keyword co-occurrences to determine distinct interdisciplinary structures. Furthermore, this study conducts a series of regression analyses to determine the associations between combinative research (based on combinative topics, methods and author affiliations) and several proxies of article performance, including usage metrics (citations and views) and effort and time expenditures (the number of days under review and the number of revisions), while controlling for article age and the journal outlet. The results indicate strong associations with multi-country author affiliations with reduced effort and time expenditures as well as increased usage and scholarly attention. Future research directions are provided that integrate with replication studies, meta-analyses, and literature reviews.
The Impact of Teleworking on Women’s Work–Life Balance and Life Satisfaction: a Longitudinal Study from Singapore
Authors: Tan Jolene , Lim-Soh Jeremy , Tan Poh Lin 
Published: June 2024

AbstractAs teleworking gains widespread global acceptance as a prevalent work arrangement, it is crucial to understand its implications for life satisfaction. Despite the increasing adoption of teleworking, few studies have examined the specific mechanisms through which it influences life satisfaction. This study used data on 358 married Singaporean women spanning six waves from 2018 to 2022, and applied path analysis to explore the effects of teleworking on life satisfaction mediated by work–life balance, workplace relationships, and working hours. The findings suggest a positive association between teleworking and life satisfaction, with work–life balance as a mediating factor. Although teleworking is associated with worsened workplace relationships and decreased working hours, the mediating effects of these factors on life satisfaction are not significant. Organizations should consider the potential benefits of teleworking for work–life balance and life satisfaction while also weighing its drawbacks.
Phylogenetic and morphological studies reveal large diversity and three new species in Amanita sect. Vaginatae (Agaricales, Basidiomycota) from Europe
Authors: Varga Dóra , Hanss Jean-Michel , Moreau Pierre-Arthur , Kovács Gábor M. , Dima Bálint 
Published: June 2024

AbstractEuropean members of the species-rich sect. Vaginatae of the genus Amanita are studied focusing on Central (Austria, Hungary, N Italy and Romania), Western (France) and North European (Norway) collections. The combination of a 4-locus (nrDNA ITS, nrDNA LSU, RPB1 and TEF1-α) molecular phylogenetic analysis and a morphological approach resulted in the discovery of three new species: Amanita deflexa and A. griseofulva from stirps Fulva and A. opaca from stirps Coryli. Furthermore, the albinotic white forms of A. griseofulva (f. albida) and A. opaca (f. cettoi) are formally named. As a result of the comprehensive taxonomic revision of Amanita sect. Vaginatae, 370 newly generated sequences are deposited to GenBank, and 17 species new to Hungary are reported. This study provides another step towards understanding the taxonomy and diversity of Amanita section Vaginatae in Europe.
Safety and effectiveness of oral anticoagulants in patients with atrial fibrillation and stage 4 chronic kidney disease: a real-world experience
Authors: Talerico Rosa , Brando Elisa , Luzi Lorenzo , Vedovati Maria Cristina , Giustozzi Michela , Verso Melina , Di Gennaro Leonardo , Basso Maria , Ferretti Antonietta , Porfidia Angelo , De Candia Erica , Pola Roberto , Agnelli Giancarlo , Becattini Cecilia 
Published: June 2024

AbstractIt is still uncertain whether direct oral anticoagulants (DOACs) perform better than vitamin K antagonists (VKAs) in subjects with non-valvular atrial fibrillation (NVAF) and advanced chronic kidney disease (CKD). The aim of the study was to compare safety and effectiveness of DOACs and VKAs in patients with NVAF and stage 4 CKD (creatinine clearance 15–29 mL/min). We searched the hospital databases of two academic centers to retrospectively identify patients with stage 4 CKD who were on treatment with DOACs or VKAs for NVAF. Safety was the primary outcome of the study and was assessed in terms of incidence of major bleeding (MB). Secondary outcomes were clinically relevant non-major bleeding (CRNMB) and death for any cause. A total of 176 patients (102 on DOACs and 74 on VKAs) were found and included in the analysis. The incidence rate of MB was not statistically different between groups (8.6 per 100 patients-year in the DOAC group and 5.6 per 100 patients-year in the VKA group). Rates of IS/SSE and CRNMB were statistically similar in the two treatment groups, as well. There were less deaths for any cause in the DOAC group than in the VKA group (8.6 and 15.8 per 100 patients-year, respectively), but the difference was not statistically significant. This study found no difference in terms of safety and effectiveness between patients with NVAF and stage 4 CKD treated with DOACs and VKAs. Larger prospective or randomized studies are needed to confirm these findings.
Use of a gas-operated ventilator as a noninvasive bridging respiratory therapy in critically Ill COVID-19 patients in a middle-income country
Authors: Arias-Sanchez Pedro P. , Wendel-Garcia Pedro D. , Tirapé-Castro Hugo A. , Cobos Johanna , Jaramillo-Aguilar Selena X. , Peñaloza-Tinoco Arianna M. , Jaramillo-Aguilar Damary S. , Martinez Alberto , Holguín-Carvajal Juan Pablo , Cabrera Enrique , Roche-Campo Ferran , Aguirre-Bermeo Hernan 
Published: June 2024

AbstractDuring the COVID-19 pandemic, there was a notable undersupply of respiratory support devices, especially in low- and middle-income countries. As a result, many hospitals turned to alternative respiratory therapies, including the use of gas-operated ventilators (GOV). The aim of this study was to describe the use of GOV as a noninvasive bridging respiratory therapy in critically ill COVID-19 patients and to compare clinical outcomes achieved with this device to conventional respiratory therapies. Retrospective cohort analysis of critically ill COVID-19 patients during the first local wave of the pandemic. The final analysis included 204 patients grouped according to the type of respiratory therapy received in the first 24 h, as follows: conventional oxygen therapy (COT), n = 28 (14%); GOV, n = 72 (35%); noninvasive ventilation (NIV), n = 49 (24%); invasive mechanical ventilation (IMV), n = 55 (27%). In 72, GOV served as noninvasive bridging respiratory therapy in 42 (58%) of these patients. In the other 30 patients (42%), 20 (28%) presented clinical improvement and were discharged; 10 (14%) died. In the COT and GOV groups, 68% and 39%, respectively, progressed to intubation (P ≤ 0.001). Clinical outcomes in the GOV and NIV groups were similar (no statistically significant differences). GOV was successfully used as a noninvasive bridging respiratory therapy in more than half of patients. Clinical outcomes in the GOV group were comparable to those of the NIV group. These findings support the use of GOV as an emergency, noninvasive bridging respiratory therapy in medical crises when alternative approaches to the standard of care may be justifiable.
Marginal analysis of count time series in the presence of missing observations
Authors: Nik Simon 
Published: June 2024

Abstract
Time series in real-world applications often have missing observations, making typical analytical methods unsuitable. One method for dealing with missing data is the concept of amplitude modulation. While this principle works with any data, here, missing data for unbounded and bounded count time series are investigated, where tailor-made dispersion and skewness statistics are used for model diagnostics. General closed-form asymptotic formulas are derived for such statistics with only weak assumptions on the underlying process. Moreover, closed-form formulas are derived for the popular special cases of Poisson and binomial autoregressive processes, always under the assumption that missingness occurs. The finite-sample performances of the considered asymptotic approximations are analyzed with simulations. The practical application of the corresponding dispersion and skewness tests under missing data is demonstrated with three real data examples.
An analysis of the predictive factors for stone clearance at primary ureteroscopy
Authors: Daly K. F. , Mac Curtain B. M , Collins E. , Lincoln M. , MacCraith E. , Lennon G. , McGuire B. B. 
Published: June 2024

Abstract
Background
Ureteric colic is a common emergency urological presentation [1]. When operative intervention is required, retrograde ureteroscopy is the most common approach. There are multiple treatment strategies including primary ureteroscopy (URS), staged ureteroscopy, and deferred ureteroscopy following ureteric stent placement. The approach is based on a number of clinical and stone factors. This study assesses the factors which predict stone clearance at the initial procedure.

Aims
All patients diagnosed with an obstructing ureteric stone who were managed operatively in a consecutive 12-month period were included. Patients were evaluated for stone clearance following a single or multiple procedures. A number of factors including stone size, location, gender, age and pre-operative laboratory results were evaluated for association with stone clearance at index procedure. Multivariate logistic regression analyses were performed to produce odds ratios (OR) with confidence interval (CI) at 95% and significance values P < 0.05.

Results
One hundred and seventy patients were included in the final analysis. Stone clearance following the index procedure was achieved in 57% (n = 100) of patients. Predictors of successful stone clearance at index procedure were stone size < 6 mm, male gender and distal stone location (p < 0.05). Proximal stone location, stone size > 10 mm and elevated c-reactive protein (CRP) were associated respectively with multiple procedures to achieve stone clearance (p < 0.05).

Conclusions
Acute ureteric stones can be managed with a number of treatment strategies. This study identifies factors which predict stone clearance at index procedure. These results will help urologists accurately counsel patients when undertaking operative management for ureteric colic.