bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turismo sustentable y desarrollo rural. Estudios en Polonia, Costa Rica y México
Authors:   Universidad de Guadalajara, Velarde Valdez Mónica , Gómez Nieves Salvador , Zulawska Urszula , Aguirre Jiménez Alma Alicia , Morán Martínez Francisco , Biamonte Castro Gino , Szulc Dabrowiecka Ewa , Sandoval Cabrera Pablo , Orozco Bravo Melchor , Covarrubias Tovar Natividad 
Published: August 2024

El turismo es una actividad económica que se establece como un importante factor de desarrollo en cualquier espacio geográfico, pero principalmente en el ámbito rural. También, es uno de los factores que más ponen en riesgo el equilibrio de los ecosistemas y uno de los causantes de la pérdida de identidad cultural de las comunidades receptoras de viajeros. Sin embargo, este fenómeno no es un problema per ser, sino del modelo de desarrollo turístico impuesto y seguido en un país. El libro, es el resultado de amplias discusiones y reflexiones entre estudiosos del turismo, que tratan de contribuir en la generación aplicado, pero también en el desarrollo turístico y la sustentabilidad a través de los denominados turismo alternativo, turismo rural, turismo sustentable, enfatizado en las políticas públicas en comunidades rurales de Polonia, Costa Rica y México.
Repeated administration of inorganic nitrate on blood pressure and arterial stiffness: a systematic review and meta-analysis of randomized controlled trials
Authors: Li Dandana , Nishi Stephanie , Jovanovski Elena , Zurbau Andrea , Komishon Allison , Blanco Mejia Sonia , Khan Tauseef , Sievenpiper John , Milicic Davorg , Jenkins Alexandra , Vuksan Vladimir 
Published: August 2024

<p> </p>
<p>Objective: </p>
<p>We aim to synthesize effects of repeated administration (≥3 days) of inorganic nitrate on blood pressure and arterial stiffness measures.</p>
<p>Methods: </p>
<p>We conducted a systematic review and meta-analysis of randomized controlled trials with at least 3 days treatment of inorganic nitrate on blood pressure and arterial stiffness in individuals with or without elevated cardiovascular disease risk. MEDLINE, EMBASE and the Cochrane Library were searched through 2 July 2019. Two independent reviewers extracted relevant study data. Data were pooled using the generic inverse variance method with random-effects model, and expressed as mean differences with 95% confidence intervals. Certainty in the evidence was assessed using GRADE.</p>
<p>Results: </p>
<p>Forty-seven trials were included (n = 1101). Administration of inorganic nitrate significantly lowered SBP [mean difference: −2.91 mmHg, 95% confidence interval (95% CI): −3.92 to −1.89, I2 = 76%], DBP (mean difference: −1.45 mmHg, 95% CI: −2.22 to −0.68, I2 = 78%], central SBP (mean difference: −1.56 mmHg, 95% CI: −2.62 to −0.50, I2 = 30%) and central DBP (mean difference: −1.99 mmHg, 95% CI: −2.37 to −1.60, I2 = 0%). There was no effect on 24-h blood pressure, augmentation index or pulse wave velocity. Certainty in the evidence was graded moderate for central blood pressure, pulse wave velocity and low for peripheral blood pressure, 24-h blood pressure and augmentation index.</p>
<p>Conclusion: </p>
<p>Repeated administration (≥3 days) of inorganic nitrate lower peripheral and central blood pressure. Results appear to be driven by beneficial effects in healthy and hypertensive individuals. More studies are required to increase certainty in the evidence. </p>
Chile GEI Index: A Comparative Study in Latin America/Carribbean
Authors: Safitri Dina 
Published: August 2024

Entrepreneurship, widely acknowledged as pivotal for economic development, has spurred global interest among policymakers, prompting the formulation of policies aimed at fostering entrepreneurial activities. Entrepreneurs, driven by vision, innovate products, processes, and services, thereby stimulating economic growth, creating employment opportunities, and bridging the gap between invention and commercialization. As economies seek ways to accelerate employment and enhance productivity, entrepreneurship emerges as a potential solution, particularly for those grappling with prolonged economic crises. To better understand and improve entrepreneurial landscapes, scholars have developed measurement methods, with the Global Entrepreneurship Index (GEI) standing out as a comprehensive model. By blending entrepreneurship with institutional factors, GEI offers insights into a country's entrepreneurial ecosystem. It comprises three sub-indexes, each reflecting entrepreneurial attitudes, abilities, and aspirations, supported by 14 pillars and 28 variables. GEI recommends five levels of index building to gauge entrepreneurship at the national level.

This study focuses on Chile's entrepreneurship profile, utilizing world data from GEI that available spanning 2015 to 2017. Chile, positioned 15th in the World GEI Index during this period, stands out as the only representative from South America/Latin America/Caribbean countries. Despite its economic strength and numerous trade agreements, Chile has room for improvement to bolster its regional standing. Entrepreneurship measurement methods encompass quantitative and qualitative approaches. While quantitative methods offer statistical insights, they may lack depth in understanding entrepreneurship's broader impact. Qualitative methods, in contrast, delve deeper into the correlation between entrepreneurship and economic development, emphasizing opportunity-driven entrepreneurship and innovation. GEI methodology offers a unique perspective, integrating institutional and cultural dimensions to assess entrepreneurship's role in economic development. Notably, GEI highlights the importance of addressing bottlenecks within entrepreneurial ecosystems, wherein the lowest-performing pillars impede overall progress. The Triple-A structure of GEI encompasses entrepreneurial attitudes, abilities, and aspirations, underpinned by 14 pillars reflecting both individual and institutional variables.
An Analysis of the Effect of Team Situation Awareness on Patient Safety Incidents using Teamwork as the Intervening Variable
Authors: Paramita Ristiya Galih , Wijaya Terivenna , Chalidyanto Djazuly , Asih Akas Yekti Pulih 
Published: August 2024

The definition of Patient Safety Incidents (PSIs) refers to specific occurrences that unintentionally happen and result in, or potentially lead to, injuries in patients if not prevented. PSIs require special attention, especially in healthcare settings. According to the report collected by the Hospital Patient Safety Committee of the Surabaya Orthopedic and Traumatology Hospital from 2018 to 2021, there were 177 patient safety incidents recorded. This study aims to analyze the effect of Team Situation Awareness (TSA) on Patient Safety Incidents through Teamwork at Surabaya Orthopedic and Traumatology Hospital. The variables identified for analysis are Team Situation Awareness (TSA) and Teamwork. Because this study was conducted over a specific time period, it follows a cross-sectional design and is an analytical observational study. Path analysis was employed to analyze the data. The measurement revealed that TSA resulted in 64.3% of work units being categorized at level 2 (comprehension), and for Teamwork, 64.3% of the works units were categorized as “Good”. The results of the Path Analysis using SmartPLS 4.0 showed the effect of TSA was significant with a p-value of <0.05, and TSA’s effect on Teamwork was also significant with a p-value of <0.05. Based on the path analysis (SEM-PLS), it was found that TSA indirectly affected PSIs through Teamwork, with a significant indirect effect having a p-value <0.05. Team Situation Awareness indirectly influenced PSIs through Teamwork. One approach to reducing the frequency of PSIs is to improve Team Situation Awareness (TSA) within each work unit at Surabaya Orthopedic and Traumatologic Hospital.

Keywords: Patient Safety Incidents, PSIs, team situation awareness, TSA, teamwork
Filsafat Pengetahuan, Teologia, Mitologi dan Warna Kehidupan Lanjut Usia sebagai Umat Kristianidi HKBP Perumnas II Bekasi Selatan
Authors: Limbong Mesta , Tampubolon Manahan. P. , Siburian Gutser 
Published: August 2024

Lanjut usia (Lansia) adalah satu proses normal bagi setiap individu. Lansia juga bukan menjadi beban bagi diri pribadi maupun lingkungan internal/eksternal. Untuk itu, regulasi di Indonesia memberikan informasi bahwa para lansia jumlahnya semakin meningkat secara Nasional di Indonesia. Lansia di HKBP Perumnas II Bekasi selatan adalah bagian dari jumlah Lansia di Indonesia. Mereka memiliki aktivitas yang terprogram, namun mereka juga membutuhkan pencerahan dari bidang keilmuan maupun implikasinya sebagai umat kristiani. Tujuan Seminar dan diskusi dengan topik yang berhubungan dengan Filsafat Pengetahuan, Teologia, Mitologi dan Warna Kehidupan Lanjut Usia Sebagai Umat Kristiani di HKBP Perumnas II Bekasi Selatan” adalah salah satu wujud Pengabdian kepada Masyarakat (PkM) dengan tujuan untuk memberikan perpestif baru bagi para lansia. Jumlah peserta yang hadir sebanyak 46 peserta (73 %) dan 17 lansia tidak hadir (27 %). Dari data ini memberikan informasi lansia yang hadir masih lebih besar jumlahnya dari yang berhalangan/tidak hadir.
Temuan dari hasil PkM: testimoni para lansia bahwa kegiatan sejenis belum pernah dilakukan sebelumnya, peserta lansia sangat antusias, dan mengharapkan kegiatan lain dapat dilakukan seperti pemeriksaan kesehatan.
Risk factors of metatarsal stress fracture associated with repetitive sports activities: a systematic review
Authors: Sun Jiayi , Feng Chenglong , Liu Yaming , Shan Mianjia , Wang Zilin , Fu Weijie , Niu Wenxin 
Published: August 2024

BackgroundMetatarsal stress fracture is common in people engaged in repetitive weight-bearing activities, especially athletes and recruits. Identifying risk factors in these contexts is crucial for effective prevention.MethodsA systematic search on Web of Science, PubMed, EBSCO, SPORTDiscus, MEDLINE, and Cochrane Library was conducted and the date range for the retrieval was set from January 1984 to April 2024.Results32 eligible studies were selected from 1,728 related research. Anatomical and biomechanical factors, such as higher foot arch, abnormal inversion/eversion of foot, and longer metatarsal length or larger angles, relatively influence stress fracture risk. However, given that there is no standardized measurement, the results remain to be examined. Soccer is associated with fifth metatarsal fractures, while long-distance running and recruit training often lead to fractures of the second or third metatarsals. High exercise intensity, non-adaptive training, and inadequate equipment heighten fracture risk.ConclusionThis review highlights the complex interplay of anatomical, biomechanical, and sports-related factors in the risk of metatarsal stress fractures. Relatively, high arches, specific metatarsal morphologies, and foot inversion/eversion patterns are significant risk factors, particularly among athletes. Sports type also correlates with metatarsal stress fracture locations. Despite extensive research, study heterogeneity and inherent biases necessitate cautious interpretation. Comprehensive, multifactorial approaches and personalized injury prevention strategies are essential for reducing the incidence of these injuries and improving the health and performance of athletes.
A framework for computer vision for virtual-realistic multi-axial real-time hybrid simulation
Authors: Saeger W. , Miranda P. , Toledo G. , Silva C. E. , Ozdagli A. , Moreu F. 
Published: August 2024

Real-time hybrid simulation has gained popularity over the last 20 years as a viable and cost-effective method of testing dynamic systems that cannot be tested using traditional methods. The emergence of multi-axial Real-time Hybrid Simulation (maRTHS) has led to an increase in the allowable fidelity of the numerical and experimental substructures. The testing community can now replicate multiple-degree-of-freedom (MDOF) responses of both substructures and thus can perform more representative tests. However, with this increased fidelity of the substructures comes an increased complexity of controlling these components. Specifically, multi-axial hydraulic actuator assemblages require nonlinear coordinate transformations to derive plant displacements as the force transducers on the actuators are not capable of performing this task directly. Recently, benchmark problems have been provided to the RTHS community in the form of virtual simulations. Virtual simulation refers to a fully virtual testing methodology where numerical and physical components are represented virtually. This approach enables the RTHS community to evaluate various control algorithms without the need to recreate physical components. This project aims to demonstrate the capability of computer vision-based displacement tracking in a realistic virtual simulation of the experimental substructure in avoiding excess nonlinear coordinate transforms. The tracking algorithm utilizing the Lucas-Kanade optical flow method is tested in the virtual simulation environment which is set up using real-time 3D creation engine, Unreal Engine 4 (UE4), and computer graphics software, Blender. This environment interfaces with MATLAB/Simulink, more specifically “Simulation Tool for v-maRTHS benchmark” developed for multi-axial tests. The result of this study establishes a novel framework for applying computer vision-based tracking algorithms and sensing in v-maRTHS simulations using simulated cameras within virtual simulation environments. A computer vision displacement tracking algorithm is developed and optimized to work in tandem with a MIMO PI controller to reduce tracking time delays within 31.25 milliseconds while tracking the nodal displacement and rotation of the frame within a normalized RMSE of 1.24 and 1.10 respectively.
Gram-scale photosynthesis of polyfunctionalized dihydro-2-oxypyrroles using 3DPAFIPN as a halogenated dicyanobenzene-based photosensitizer via a consecutive visible-light-induced electron transfer process
Authors: Mohamadpour Farzaneh , Amani Ali Mohammad 
Published: August 2024

BackgroundTypically, organic dyes show lower excited state lifetimes, a key hindrance in the development of efficient photoredox processes. Due to their distinctive qualities and efficiency, a particular class of organic chromophores has drawn considerable interest from the scientific community. Thermally activated delayed fluorescence (TADF), is only seen in molecules with a minimal energy gap (usually less than 0.2 eV) between their lowest two excited states, i.e., singlet excited state (S1) and triplet excited state (T1), is a distinctive property of the molecules under study. Isophthalonitriles are a promising family of chromophores for use as organic photocatalysts because of the ease with which their redox potentials may be adjusted and the prolonged singlet excited states resulting from TADF.MethodsA sustainable process for the photosynthesis of polyfunctionalized dihydro-2-oxypyrroles has been developed using the Michael-Mannich cyclocondensation of amines, dialkyl acetylenedicarboxylates, and formaldehyde. The development of a green radical synthesis strategy for this family of chemicals is discussed in detail in the current work. This work used a novel halogenated dicyanobenzene-based photosensitizer was used as a photocatalyst. It was dissolved in ethanol, exposed to air at ambient temperature, and triggered by a blue light-emitting diode as a renewable energy source. This project’s main goal is to use a novel conveniently accessible, reasonably priced donor-acceptor (D-A) based on halogenated cyanoarene.FindingsWhen exposed to visible light, the 3DPAFIPN [2,4,6-tris(diphenylamino)-5-fluoroisophthalonitrile] photocatalyst, which is a thermally activated delayed fluorescence (TADF), can induce single-electron transfer (SET), providing a simple and green method that is highly effective, energy-efficient, and environmentally friendly. Also, we calculated the turnover number (TON) and turnover frequency (TOF) for polyfunctionalized dihydro-2-oxypyrroles. Gram-scale cyclization has also been shown to be a practical technique for use in industrial applications.
From serum metabolites to the gut: revealing metabolic clues to susceptibility to subtypes of Crohn’s disease and ulcerative colitis
Authors: Li Fan , Wang Zhaodi , Tang Tongyu , Zhao Qi , Wang Zhi , Han Xiaoping , Xu Zifeng , Chang Yu , Li Hongyan , Hu Sileng , Yu Chanjiao , Chang Shiyu , Liu Yue , Li Yuqin 
Published: August 2024

Background and aimsInflammatory bowel disease (IBD) is a common chronic inflammatory bowel disease characterized by diarrhea and abdominal pain. Recently human metabolites have been found to help explain the underlying biological mechanisms of diseases of the intestinal system, so we aimed to assess the causal relationship between human blood metabolites and susceptibility to IBD subtypes.MethodsWe selected a genome-wide association study (GWAS) of 275 metabolites as the exposure factor, and the GWAS dataset of 10 IBD subtypes as the outcome, followed by univariate and multivariate analyses using a two-sample Mendelian randomization study (MR) to study the causal relationship between exposure and outcome, respectively. A series of sensitivity analyses were also performed to ensure the robustness of the results.ResultsA total of 107 metabolites were found to be causally associated on univariate analysis after correcting for false discovery rate (FDR), and a total of 9 metabolites were found to be significantly causally associated on subsequent multivariate and sensitivity analyses. In addition we found causal associations between 7 metabolite pathways and 6 IBD subtypes.ConclusionOur study confirms that blood metabolites and certain metabolic pathways are causally associated with the development of IBD subtypes and their parenteral manifestations. The exploration of the mechanisms of novel blood metabolites on IBD may provide new therapeutic ideas for IBD patients.
Causal association of type 2 diabetes with central retinal artery occlusion: a Mendelian randomization study
Authors: Liu Tong , Lu Qingli , Liu Zhongzhong , Lin Xuemei , Peng Linna , Lu Xiping , Guo Weiyan , Liu Pei , Zhang Na , Wu Songdi 
Published: August 2024

BackgroundCentral retinal artery occlusion (CRAO) is a medical condition characterized by sudden blockage of the central retinal artery, which leads to a significant and often irreversible loss of vision. Observational studies have indicated that diabetes mellitus is a risk factor for CRAO; however, there is no research on the causal relationship between diabetes mellitus, particularly type 2 diabetes, and CRAO. This study aimed to perform Mendelian randomization (MR) analysis to clarify the causal relationship between type 2 diabetes and CRAO.MethodsGenetic variants associated with type 2 diabetes were selected from two different datasets. A recent genome-wide association study of CRAO conducted using the FinnGen database was used as the outcome data. A two-sample MR was performed to evaluate the causal relationship between type 2 diabetes and CRAO. Inverse variance weighting was the primary method, and MR-Egger, maximum likelihood, and median weighting were used as complementary methods. A multivariate MR (MVMR) analysis was performed to further evaluate the robustness of the results. Cochran’s Q test, MR-Egger intercept test, and MR-PRESSO global test were used for the sensitivity analyses.ResultsGenetically predicted type 2 diabetes was causally associated with CRAO(odds ratio [OR] =2.108, 95% confidence interval [CI]: 1.221–3.638, P=7.423×10-3), which was consistent with the results from the validation dataset (OR=1.398, 95%CI: 1.015–1.925, P=0.040). The MVMR analysis suggested that type 2 diabetes may be an independent risk factor for CRAO (adjusted OR=1.696; 95%CI=1.150–2.500; P=7.655×10-3), which was assumed by the validation dataset (adjusted OR=1.356; 95%CI=1.015–1.812; P=0.039).ConclusionOur results show that genetically predicted type 2 diabetes may be causally associated with CRAO in European populations. This suggests that preventing and controlling type 2 diabetes may reduce the risk of CRAO.
46,XX males with congenital adrenal hyperplasia: a clinical and biochemical description
Authors: Adriaansen Bas P. H. , Utari Agustini , Westra Dineke , Juniarto Achmad Zulfa , Ariani Mahayu Dewi , Ediati Annastasia , Schröder Mariska A. M. , Span Paul N. , Sweep Fred C. G. J. , Drop Stenvert L. S. , Faradz Sultana M. H. , van Herwaarden Antonius E. , Claahsen – van der Grinten Hedi L. 
Published: August 2024

IntroductionCongenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) or 11-hydroxylase deficiency (11OHD) is characterized by underproduction of cortisol and overproduction of adrenal androgens. These androgens lead to a variable degree of virilization of the female external genitalia in 46,XX individuals. Especially in developing countries, diagnosis is often delayed and 46,XX patients might be assigned as males. This study aims to describe the clinical and biochemical characteristics of a unique cohort of untreated male-reared 46,XX classic CAH patients from Indonesia and discusses treatment challenges.MethodsNine untreated classic CAH patients with 46,XX genotype and 21OHD (n=6) or 11OHD (n=3), aged 3-46 years old, were included. Biometrical parameters, clinical characteristics, and biochemical measurements including glucocorticoids, renin, androgens, and the pituitary-gonadal axis were evaluated.ResultsAll patients had low early morning serum cortisol concentrations (median 89 nmol/L) without significant increase after ACTH stimulation. Three patients with salt wasting 21OHD reported one or more periods with seizures and/or vomiting in their past until the age of 6, but not thereafter. The remaining patients reported no severe illness or hospitalization episodes, despite their decreased capacity to produce cortisol. In the 21OHD patients, plasma renin levels were elevated compared to the reference range, and in 11OHD patients renin levels were in the low-normal range. All adult patients had serum testosterone concentrations within the normal male reference range. In 21OHD patients, serum 11-oxygenated androgens comprised 41-60% of the total serum androgen concentrations. Glucocorticoid treatment was offered to all patients, but they refused after counseling as this would reduce their endogenous androgen production and they did not report complaints of their low cortisol levels.DiscussionWe describe a unique cohort of untreated classic 46,XX male CAH patients without overt clinical signs of cortisol deficiency despite their cortisol underproduction and incapacity to increase cortisol levels after ACTH stimulation. The described adolescent and adult patients produce androgen levels within or above the normal male reference range. Glucocorticoid treatment will lower these adrenal androgen concentrations. Therefore, in 46,XX CAH patients reared as males an individual treatment approach with careful counseling and clear instructions is needed.