bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Glenoid Bone Loss and Shoulder Position on Axillary Nerve Anatomy During the Latarjet Procedure
Authors: Carbone Andrew D. , Kwak Daniel , Chung Min-Shik , McGarry Michelle H. , Nakla Andrew P. , Banffy Michael B. , Lee Thay Q. 
Published: August 2024

Background: The Latarjet procedure is increasingly being utilized for the treatment of glenoid bone loss and has a relatively high neurological complication rate. Understanding the position-dependent anatomy of the axillary nerve (AN) is crucial to preventing injuries. Purpose: To quantify the effects of changes in the shoulder position and degree of glenoid bone loss during the Latarjet procedure on the position of the AN. Study Design: Controlled laboratory study. Methods: A total of 10 cadaveric shoulders were dissected, leaving the tendons of the rotator cuff and deltoid for muscle loading. The 3-dimensional position of the AN was quantified relative to the inferior glenoid under 3 conditions: (1) intact shoulder, (2) Latarjet procedure with 15% bone loss, and (3) Latarjet procedure with 30% bone loss. Measurements were obtained at 0°, 30°, and 60° of glenohumeral abduction (equivalent to 0°, 45°, and 90° of shoulder abduction) and at 0°, 45°, and 90° of humeral external rotation (ER). Results: Abduction of the shoulder to 60° resulted in a posterior (9.5 ± 1.1 mm; P < .001), superior (3.0 ± 1.2 mm; P = .013), and lateral (19.1 ± 2.3 mm; P < .001) shift of the AN, and ER to 90° resulted in anterior translation (10.0 ± 1.2 mm; P < .001). Overall, ER increased the minimum AN-glenoid distance at 30° of abduction (14.9 ± 1.3 mm [0° of ER] vs 17.3 ± 1.5 mm [90° of ER]; P = .045). The Latarjet procedure with both 15 and 30% glenoid bone loss resulted in a superior and medial shift of the AN relative to the intact state. A decreased minimum AN-glenoid distance was seen after the Latarjet procedure with 30% bone loss at 60° abduction and 90° ER (17.7 ± 1.6 mm [intact] vs 13.9 ± 1.6 mm [30% bone loss]; P = .007), but no significant differences were seen after the Latarjet procedure with 15% bone loss. Conclusion: Abduction of the shoulder induced a superior, lateral, and posterior shift of the AN, and ER caused anterior translation. Interestingly, the Latarjet procedure, when performed on shoulders with extensive glenoid bone loss, significantly reduced the minimum AN-glenoid distance during shoulder abduction and ER. These novel findings imply that patients with substantial glenoid bone loss may be at a higher risk of AN injuries during critical portions of the procedure. Consequently, it is imperative that surgeons account for alterations in nerve anatomy during revision procedures. Clinical Relevance: This study attempts to improve understanding of the position-dependent effect of shoulder position and glenoid bone loss after the Latarjet procedure on AN anatomy. Improved knowledge of AN anatomy is crucial to preventing potentially devastating AN injuries during the Latarjet procedure.
Arthroscopic Bankart Repair for Anterior Glenohumeral Instability in 488 Adolescents Between 2000 and 2020: Risk Factors for Subsequent Recurrent Instability Requiring Revision Stabilization
Authors: Kay Jeffrey , Heyworth Benton E. , Bae Donald S. , Kocher Mininder S. , Milewski Matthew D. , Kramer Dennis E. 
Published: August 2024

Background: After arthroscopic Bankart repair (ABR) for anterior glenohumeral instability (GHI), adolescent athletes have higher rates of subsequent recurrent GHI than any other subpopulation. Elucidating which adolescents are at highest risk of postoperative recurrent GHI may optimize surgical decision-making. Purpose: To identify prognostic factors associated with subsequent recurrent GHI requiring revision stabilization surgery (RSS) after ABR. Study Design: Case-control study; Level of evidence, 3. Methods: The study included patients 12 to 21 years old who had undergone ABR for anterior GHI at a pediatric tertiary care hospital by 1 of 5 sports medicine fellowship–trained surgeons between 2000 and 2020. A multivariate Cox proportional hazards model, with percentage of patients with recurrent GHI undergoing subsequent RSS, was used with a time-to-event outcome analysis. The Cox model effects were expressed as the hazard ratio (HR). All tests were 2-sided, with an alpha of .05. Results: Records of 488 adolescent patients with ABR (78% male; mean age, 16.9 ± 1.98 years) were analyzed. Of these, 86 patients (17.6%) underwent subsequent RSS for recurrent GHI, yielding a cumulative risk of 8.8% at 2 years, 16.5% at 5 years, and 20% at 15 years. RSS occurred at a mean of 2.6 ± 2.1 years after ABR. Risk factors for RSS included >1 preoperative dislocation (2 dislocations: HR = 7.4, P = .0003; ≥3 dislocations: HR = 10.9, P < .0001), presence of a Hill-Sachs lesion (small: HR = 2.5, P = .0114; medium-large: HR = 4.2, P = .0004), younger age (1-year decrease: HR = 1.2, P = .0015), and participation in contact sports (HR = 1.8, P = .01). Adolescents with only 1 preoperative dislocation had a cumulative incidence of RSS (3.2%), which was significantly lower than those with 2 (24.2%) or ≥3 preoperative dislocations (33.5%). Conclusion: The number of dislocations before index ABR was the strongest risk factor for recurrent GHI requiring RSS in adolescents with anterior GHI, with 2 dislocations conferring >7-fold increased risk compared with a single preoperative dislocation. Other significant risk factors included the presence of a Hill-Sachs lesion, younger age, and participation in contact sports.
Lipopolysaccharide-induced bacterial infection model: microRNA-370-3p participates in the anti-infection response by targeting the macrophage TLR4-NLRP3 caspase-1 cellular pyroptosis pathway
Authors: Liu Wen , Chen Haiyun , Xia Fengli , Lu Lu , Reyimu Abdusemer , Pawuziye Paerhati , Li Yadong , Xu Aimin , Zou Xiaoguang 
Published: August 2024

Objective To explore the effect of miR-370-3p on LPS triggering, in particular its involvement in disease progression by targeting the TLR4-NLRP3-caspase-1 cellular pyroptosis pathway in macrophages. Methods Human macrophage RAW264.7 was divided into 6 groups: control, LPS, LPS + inhibitor-NC, LPS + miR-370-3p inhibitor, LPS + mimics-NC and LPS + miR-370-3p mimics. RT-qPCR was used to detect the expression level of miR-370-3p and analyzed comparatively. CCK-8 and flow cytometry assays were used to detect cell viability and apoptosis. ELISA assay was used to detect the levels of IL-1β and TNF-α in the supernatant of the cells. The WB assay was used to detect TLR4, NLRP3, Caspase-1 and GSDMD levels. Results After LPS induction, macrophage miR-370-3p levels decreased, cell viability decreased, and apoptosis increased. At the same time, the levels of TLR4, NLRP3, Caspase-1 and GSDMD increased in the cells, and the levels of IL-1β and TNF-α increased in the cell supernatant. Compared with the LPS group, the significantly higher expression level of miR-370-3p in the cells of the LPS + miR-370-3p mimics group was accompanied by significantly higher cell viability, significantly lower apoptosis rate, significantly lower levels of TLR4, NLRP3, Caspase-1, and GSDMD in the cells, and significantly lower levels of IL-1β and TNF-α in the cell supernatant. Conclusion MiR-370-3p may be involved in anti-infective immune responses by targeting and inhibiting the macrophage TLR4-NLRP3-caspase-1 cellular pyroptosis pathway.
Role of Entrepreneurship Education Program Triggers and Perceived Social Support in Student’s Entrepreneurship Intention Formation
Authors: Mitra Remi , Sharma Mahendra , Purohit Rajen 
Published: August 2024

Purpose: The research paper aims to understand the influence of specific triggers derived from entrepreneurship education programs (EEPs) on students’ intentions. Additionally, it extends the theory of planned behavior by including an additional construct of perceived social support (PSS) as a determinant of students’ entrepreneurship intention (EI). Methodology: A sample of 395 university students from the Indian state of Gujarat, who had previously attended EEPs, was selected. A convenient sampling method was employed to validate the scale, which was further refined using confirmatory factor analysis in the first stage and through the measurement model in Partial Least Squares Structural Equation Modeling (PLS-SEM) in the second step. Findings: The triggers derived from assessed EEPs had a significant impact on EI and its antecedents. While PSS did not have any significant impact on attitude, it did have considerable influence on perceived behavior control and subjective norms. Practical Implications: Universities should extensively address the trigger component in EEPs. It is the trigger derived from these programs that raises attitudes and intentions toward entrepreneurship. This article also confirms that PSS is essential for the development of EI, owing to which, policy support from government and universities does enhance the students’ enthusiasm to pursue sustainable entrepreneurship. Originality/Value: This research makes unique contribution to entrepreneurship literature by considering the role of ‘triggers’ that are acquired from EEPs because they raise the attitudes and intentions among students.
Moderating Effect of Demographic Factors on the Relationship Between Work Motivation and Employee Retention of Gen Z
Authors: Ganguli Rajorshi , Padhy Suresh Chandra 
Published: August 2024

Purpose: This study aimed to investigate the variations in work motivation and Gen Z employee retention concerning the demographic characteristics of the employees and to assess the moderating impact of demographic variables on the relationship between work motivation and Gen Z employee retention. Design/Methodology/Approach: The empirical research was conducted by employing a quantitative research design from Indian Gen Z employees working at various organizations. A cross-sectional time frame was followed, wherein data was collected from 755 participants for their perception of work motivation and employee retention using a questionnaire. Descriptive and inferential statistical methods were used to examine the relationships between the study variables and to validate the developed model for the study using Smart PLS v3 software. Findings: Overall, the study found that workplace motivation has a significant effect on Gen Z employees’ retention. Moreover, the association between job motivation and Gen Z employee retention was moderated by gender, income, and industry type. However, the association between work motivation and Gen Z employee retention was unaffected by the level of education. Research Implications: The findings of the study specifically provide insights for HR practitioners. It can be implied that motivating employees and retaining them are among the essential elements of every organization. The organizations must create equal opportunities for males and females.
Equity Crowdfunding: A Bibliometric Analysis of the State of Research
Authors: Tiwari Chandan Kumar , Vadgama Chintan , Pal Abhinav , Gupta Kanishka 
Published: August 2024

Purpose: Equity crowdfunding is a growing practice in the expansion of entrepreneurial finance. Young entrepreneurs and investors find it very effective due to the high penetration of the internet and social media in this globalized world. This innovative source of entrepreneurial finance has certainly fostered small businesses and entrepreneurship. The primary objective of this research is to examine in an exhaustive and systematic way the studies of crowdfunding in actions. Methodology: This study has employed a Systematic Review of Literature and Bibliometric Analysis has been conducted. This study seeks to comprehend the current development, benefits, and challenges within the domain of equity crowdfunding. Findings: In addition to the potential benefits, the study also highlights the opportunities and challenges of fundraising through equity crowdfunding platforms for fundraisers and investors around the world. Crowdfunding and entrepreneurship, equity crowdfunding is often used for sustainability, development, finance, and investment and is mainly studied with reference to the UK region. Originality: The research study makes a contribution to the existing literature by highlighting the current developments and the contributions made by scholars around the world with the assistance of content and bibliometric analysis.
YouTube “Unboxing:” An Influencer of Purchase Intent—A Quantitative Study
Authors: Bhattacharya Arijit , Dhingra Priyanka Mathur 
Published: August 2024

Purpose: Unboxing is a relatively new social media occurrence, where a YouTube unboxer’s amateur video gradually unwraps and reviews a new product for the followers. The phenomenon has caught the attention of both the marketing industry and academia due to its potential to influence purchase intent. The present research focuses on the relevant unboxing literature with a special focus on source characteristics, purposive motives, and nonpurposive motives; hypothesizes a research model and empirically tests it to probe how the unboxing phenomenon influences purchase intention. Design/Methodology/Approach: The researchers conducted an online survey for data collection from 705 social media users and used structural equation modeling and moderation analysis for data analysis. Findings: The present research proposed and tested a model of unboxing using parasocial interaction (PSI). It found that PSI does influence purchase intent in unboxing and found support for six out of seven antecedents of PSI hypothesized in the model. Practical Implications: The findings of the study can help marketing organizations to understand the importance of YouTube influencer-induced PSI to design effective advertising campaigns through influencer marketing in order to drive purchase intent. Originality/Value: The present study aims to understand the unboxing phenomenon by analyzing the proposed model. This study contributes to the limited literature on the nascent YouTube unboxing in an emerging economy context and extends previous research in this field by incorporating new variables. Also, it studies the effect of gender as a moderator in an unboxing context for the first time.
Unlocking the benefits of montessori-based reading activities in nursing home: A multiple baseline study on groups of individuals with severe dementia
Authors: Bourgeois Cécile , Brigaud Emmanuelle , Louis Ella , Azzoune Lynda , Gambonnet Marie , Vitou Valérie , Jeandel Claude , Erkes Jérôme , Bayard Sophie 
Published: August 2024

Objective Group activities are commonly offered to residents of nursing homes, and increasingly with a person-centred care approach. The aim of this study is to compare the impacts of a Montessori-based reading activity with a more traditional reading activity. Method A multiple baseline design was used, with 3 groups of 5 older adults with moderate to severe dementia. All sessions were videorecorded and analysed by independent judges, blinded to our hypotheses and conditions. Impacts of the type of activity (storytelling or Montessori-based reading) on verbal interactions, engagement level, affect and behavioural aspects were estimated with both visual analyses and statistical analyses using the between-case standardised mean differences method. Results Significant differences were found in favour of the Montessori-based activities with regard to the number of verbal interactions, constructive and passive engagement and positive affect expressed, with moderate to large effect size (from 0.46 to 1.66). Conclusion The Montessori-based reading group activity really seems to be preferable to a more traditional storytelling activity, with multiple benefits for residents. Depending on the preserved abilities and interests of the participants, it can also be aimed at people with severe dementia.
Technical Aspects of Exclusive Transfemoral Route for Total Endovascular Arch Repair: A Custom-Made Device With Only Upward-Facing Inner Branches for Aortic Arch Treatment
Authors: Ferreira Marcelo , Mannarino Matheus , Cunha Rodrigo , Ferreira Diego , Capotorto Luiz Fernando , Mannarino Guilherme 
Published: August 2024

Purpose: The purpose was to demonstrate a new arch endograft configuration to allow total endovascular aortic arch repair exclusive from transfemoral approach. Technique: The custom-made multi-branched arch endograft (Cook Medical, Bloomington, Indiana) features 3 inner branches (IBs) for supra-aortic vessels incorporation and complete endovascular arch repair. Traditionally, the innominate and left carotid branches are anterograde IBs, requiring upper access for incorporation of these vessels, and the left subclavian branch is an upward-facing IB that can be incorporated from transfemoral access. We report a novel device configuration with only upward-facing IBs, allowing exclusive transfemoral route for total endovascular arch repair. Technical aspects, implantation technique, and limitations are described thoroughly. Conclusion: Herein is described an arch endograft configuration that simplifies endovascular aortic arch repair, allowing supra-aortic vessel incorporation through a transfemoral route only. This innovative design may serve as another alternative in selected patients. Clinical Impact This innovative endograft design, with only upward-facing inner branches, simplifies the total endovascular aortic arch repair by allowing for a exclusively transfemoral approach. This may reduce procedural complexity and minimizes risks associated with multiple access points. It provides another alternative, particularly beneficial for selected high-risk patients for open repair, potentially expanding the applicability of endovascular treatments for aortic arch pathologies.
Pretreatment pulmonary tumor necrosis is a promising prognostic imaging biomarker for first-line anti-PD-1/PD-L1 therapy in advanced lung squamous cell carcinoma: a multi-institutional, propensity score-matching cohort analysis
Authors: Zhong Qiaofeng , Zhang Longfeng , Wu Lin , Zhao Jun , Sun Jianguo , Fang Yong , Zhou Jin , Chu Qian , Shen Yihong , Yang Zhenzhou , Chen Lijin , Huang Meijuan , Lin Xiaoyan , Liu Zhenhua , Shen Peng , Wang Zhijie , Wang Xin , Wang Huijuan , Han Chengbo , Liu Anwen , Zhang Hongmei , Ye Feng , Gao Wen , Wu Fang , Song Zhengbo , Chen Shengchi , Zhou Chengzhi , Huang Dingzhi , Zhang Qiuyu , Zheng Xinlong , Zheng Xiaobin , Miao Qian , Jiang Kan , Zou Zihua , Xu Yiquan , Wu Shiwen , Wang Haibo , Hong Yaping , Lu Tao , Li Chao , Huang Cheng , Chen Chuanben , Lin Gen 
Published: August 2024

Background: Tumor necrosis (TN) is a common feature in lung squamous cell carcinoma (LSCC), which could provide useful predictive and prognostic information. Objectives: This study aimed to investigate the effect of pretreatment pulmonary TN (PTN) on the prognosis of first-line anti-programmed cell death 1 (PD-1)/PD ligand 1 (PD-L1) inhibitor in advanced LSCC. Design: We conducted a retrospective study to analyze the association between the presence of PTN and clinical outcomes in advanced LSCC patients treated with anti-PD-1/PD-L1 inhibitors. Methods: Data from 240 eligible patients were collected from 27 hospitals across China between 2016 and 2020. The presence of PTN was assessed using contrast-enhanced chest computed tomography (CT) imaging at baseline. We utilized the Cox proportional-hazards regression model to analyze the association between PTN and clinical outcomes. In addition, to account for potential confounding factors and ensure comparability between groups, we employed propensity score-matching (PSM) analysis. Results: In the overall patient cohort, the presence of PTN was 39.6%. The median follow-up duration was 20.3 months. The positive PTN group exhibited a notably inferior median progression-free survival (PFS; 6.5 months vs 8.6 months, p = 0.012) compared to the negative PTN group. Within the Cox proportional-hazards regression model, PTN emerged as an independent predictor of unfavorable PFS (hazard ratio (HR) = 1.354, 95% confidence interval (CI): 1.002–1.830, p = 0.049). After PSM, the median PFS for the positive PTN group (6.5 months vs 8.0 months, p = 0.027) remained worse than that of the negative PTN group. Multivariate analyses also further underscored that the presence of PTN independently posed a risk for shorter PFS (HR = 1.494, 95% CI: 1.056–2.112, p = 0.023). However, no statistically significant difference in overall survival was observed between the two groups. Conclusion: Our study suggests that the presence of PTN on baseline contrast-enhanced chest CT is a potential negative prognostic imaging biomarker for the outcome of anti-PD-1/PD-L1 inhibitor therapy in advanced LSCC. Further studies are warranted to validate these findings and explore the underlying mechanisms.
Effectiveness of Injection Strategies on Patients With Patellar Tendonitis (Jumpers’ Knee): A Network Meta-analysis of Randomized Controlled Trials
Authors: Wang Shaowei , Lyu Buwei 
Published: August 2024

Context: Patellar tendonitis (PT) is a common degenerative disease of the patellar tendon that seriously affects the sports careers of elite athletes and activities of daily living of sports enthusiasts. Injection therapy is a prevalent invasive treatment for PT. Objective: This work comprehensively analyzes various injection treatments for PT that consider agent type and characteristics, frequency, and assessment timepoints by meta-analysis. Data Sources: PubMed, Embase, and the Cochrane Library were sources of data. Data Selection: Randomized controlled trials (RCTs) analyzing the effect of various injection strategies on the treatment of patients with PT were considered. Study Design: Systematic review and meta-analysis. Level of Evidence: Level 2. Data Extraction: First author, year of publication, research location, registration information, patient type, sample size, age, sex, intervention, control treatment, and follow-up period in each study were extracted. Results: Nineteen RCTs were included in the analysis. In the network meta-analysis of Victorian Institute of Sports Assessment-Patellar (VISA-P) outcomes, polidocanol (standardized mean difference (SMD), 6.52; 95% CI 4.75, 8.30; P < 0.01), tenocyte-like cells (SMD, 4.08; 95% CI 2.92, 5.25; P < 0.01), and leukocyte-poor platelet-rich plasma (LP-PRP) plus high-volume image-guided injection (HVIGI) (SMD, 1.56; 95% CI 0.62, 2.50; P < 0.01) were significantly superior to noninjection conservative treatment, mainly at the 6-month follow-up timepoint. For visual analog scale results, multiple dry needling (DN) (SMD, -1.78; 95% CI -2.56, -1.00; P < 0.01), LP-PRP (SMD, -0.71; 95% CI -1.31, -0.12; P = 0.02), and LP-PRP plus HVIGI (SMD, -1.31; 95% CI -2.22, -0.39; P < 0.01) were significantly superior to blank, which was also mainly at the 6-month timepoint. Conclusion: Injection-related treatments: polidocanol, tenocyte-like cells, LP-PRP, and multiple DN showed potential short (1-3 months) or medium (6 months)-term treatment benefits. There is still no evidence for injection interventions with long-term therapeutic benefit.