bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brain arteriovenous malformations associated with hereditary hemorrhagic telangiectasia: Gene–phenotype correlations
Authors: Nishida Takeo , Faughnan Marie E. , Krings Timo , Chakinala Murali , Gossage James R. , Young William L. , Kim Helen , Pourmohamad Tony , Henderson Katharine J. , Schrum Stacy D. , James Melissa , Quinnine Nancy , Bharatha Aditya , terBrugge Karel G. , White Robert I. 
Published: September 2012

AbstractHereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disease with a wide spectrum of vascular malformations (VMs) involving multiple organs. Nine to 16% of patients with HHT harbor brain arteriovenous malformations (AVMs), which can cause intracranial hemorrhage (ICH). Our objective was to study clinical manifestations of brain AVMs in patients with HHT and correlate these with the specific gene mutated. We reviewed records of 171 patients with HHT and brain AVMs. A history of ICH was found in 27% (41/152) patients, with a mean age of 26 ± 18 range, (0–68) years. All of patients with ICH were neurologically asymptomatic prior to ICH. Multiple brain AVMs were found in 23% (170/39) of patients on initial examination. Genetic test results were available in 109 (64%) patients. Mutations in ENG, ACVRL1, and SMAD4 were present in 75 (69%), 18 (17%), and 2 (2%), respectively. A history of ICH was reported in 24% of patients with an ENG mutation and 27% of patients with an ACVRL1 mutation, with a mean age of 26 ± 16 (range, 2–50) and 18 ± 21 (0–48) years, respectively. No statistically significant differences in age at first brain AVM diagnosis, prevalence of ICH history, age at ICH, or other manifestations of brain AVMs were observed among gene groups. In conclusion, no evidence for differences in brain AVM characteristics was observed among HHT gene groups, although we cannot exclude clinically important differences. Larger studies are needed to further guide brain AVM screening decisions in patients with HHT. © 2012 Wiley Periodicals, Inc.
Environmental Requirements, Knowledge Sharing and Green Innovation: Empirical Evidence from the Electronics Industry in China
Authors: Wong Stanley Kam Sing 
Published: September 2012

ABSTRACTBuilding on the Porter hypothesis, which posits that regulatory stringency triggers innovation and thereby allows firms to achieve the dual purpose of environment protection and enhanced business performance, the present research develops an integrative model that explores the determinants of green innovation with a focus being placed on knowledge sharing. Data were collected from 203 green innovation project leaders from electronics manufacturers operating in China. The results indicate that knowledge sharing mediates the relationship between green requirements and new green product success as well as that between green requirements and green product and process innovations. Interestingly, the empirical analysis rejects the hypothesized positive influence of green requirements on green product and process innovations as well as that on new green product success, while confirming that there exists a direct and positive association between green requirements and knowledge sharing. The direct positive impact of knowledge sharing is the strongest on green process innovation. This study provides a theoretical basis for investigating the possible determinants in the causal links between green requirements and green innovation success and establishes that knowledge sharing and green process innovation may be the points where leverage can be applied to best secure innovation success. Implications of the findings on environmental policy and law design are also discussed to see how the regulatory role of the government can be better positioned to facilitate compliance and innovation. Copyright © 2012 John Wiley & Sons, Ltd and ERP Environment.
Clinically relevant landmarks of the frontotemporal branch of the facial nerve: A three‐dimensional study
Authors: Davies Joel C. , Fattah Adel , Ravichandiran Mayoorendra , Agur Anne M. 
Published: September 2012

AbstractThe frontotemporal branch of the facial nerve (FTN) is vulnerable during craniofacial surgeries due to its superficial course and variable distribution. Surface landmarks that correlate with the underlying course of the FTN can assist in surgical planning. Estimates of the course of FTN commonly rely on Pitanguy's line (PL), which utilizes variable soft‐tissue landmarks. The purpose of this study was to evaluate palpable surface landmarks to predict the course and distribution of FTN using 3D modeling. Fifteen half‐heads were used. In five formalin‐embalmed specimens, surface topography was obtained using a FARO® scanner and landmarks corresponding to PL, porion, supraorbital notch, frontozygomatic and zygomaticotemporal sutures, and supraorbitomeatal line (SOML) and infraorbitomeatal line (IOML) were demarcated/digitized using a Microscribe™ digitizer. A preauricular flap was raised, and branches of FTN were isolated and digitized. The data were reconstructed into 3D models (Geomagic®/Maya®) to quantify landmarks. In 10 Thiel‐embalmed specimens, four independent raters identified/palpated and pinned the frontozygomatic and zygomaticotemporal sutures and PL. Data were collected and analyzed using the same protocol as in the first part of the study. Landmarking of PL was inconsistent between raters and not representative of FTN distribution. The easily identifiable surface landmarks defined in this study, a line 12 mm anterior to the porion along the SOML and IOML and a line joining the zygomaticotemporal and frontozygomatic sutures, comprehensively captured the distribution of FTN. The raters found a mean of 21 ± 2 branches between the lines out of a total of 22 ± 2 branches. These landmarks may be used clinically to avoid injury to FTN. Clin. Anat. 25:858–865, 2012. © 2012 Wiley Periodicals, Inc.
Conformational Analysis of Fluorinated Pyrrolidines Using 19F–1H Scalar Couplings and Heteronuclear NOEs
Authors: Combettes Lorraine E. , Clausen‐Thue Philip , King Michael A. , Odell Barbara , Thompson Amber L. , Gouverneur Véronique , Claridge Tim D. W. 
Published: September 2012

AbstractA series of 3‐fluoropyrrolidines have been studied to investigate the influence of the stereoelectronic fluorine gauche effect on ring conformations in the solid state by single‐crystal X‐ray analysis and in solution phase by NMR spectroscopy. As part of these studies 1D 19F–1H heteronuclear NOE (HOESY) experiments have been optimised for applications to small molecules and are described in detail. These have been employed to estimate 19F–1H internuclear distances and were combined with vicinal 3J(F,H) and 3J(H,H) scalar coupling constants to analyse the ring conformations. Where possible the derived solution‐phase structural data have been compared with those of the crystalline state. The results demonstrate the influence of the gauche effect in stabilising Cγ‐exo conformations of the fluorinated pyrrolidines. It was further shown that when steric interactions were also present, this conformational bias was diminished and the contribution of the alternative Cγ‐endo conformation was seen to increase in solution at lower sample temperatures.
Labour Arbitration of Co‐Worker Sexual Harassment Cases in Canada
Authors: Hart Susan M. 
Published: September 2012

AbstractWomen have the right to a workplace free from sexual harassment under Canadian provincial and federal human rights legislation. Canadian labour laws incorporate the right to a grievance procedure including binding arbitration where arbitrators must interpret and apply human rights legislation. This paper analyzes co‐worker sexual harassment cases in order to assess how well arbitrations protect the right of unionized women to a harassment free workplace. Results indicate that women complainants were often subjected to aggressive gendered cross‐examinations and the application of gendered jurisprudence that largely ignored the impact of gendered power relations in the workplace. The conclusion is that women's experiences in arbitrations are likely a deterrent to filing formal complaints, effectively undermining rather than protecting their rights. Copyright © 2012 ASAC. Published by John Wiley & Sons, Ltd.
UBE4B levels are correlated with clinical outcomes in neuroblastoma patients and with altered neuroblastoma cell proliferation and sensitivity to epidermal growth factor receptor inhibitors
Authors: Zage Peter E. , Sirisaengtaksin Natalie , Liu Yin , Gireud Monica , Brown Brandon S. , Palla Shana , Richards Kristen N. , Hughes Dennis P. M. , Bean Andrew J. 
Published: September 2012

AbstractBACKGROUND:The UBE4B gene, which is located on chromosome 1p36, encodes a ubiquitin ligase that interacts with hepatocyte growth factor‐regulated tyrosine kinase substrate (Hrs), a protein involved in epidermal growth factor receptor (EGFR) trafficking, suggesting a link between EGFR trafficking and neuroblastoma pathogenesis. The authors analyzed the roles of UBE4B in the outcomes of patients with neuroblastoma and in neuroblastoma tumor cell proliferation, EGFR trafficking, and response to EGFR inhibition.METHODS:The association between UBE4B expression and the survival of patients with neuroblastoma was examined using available microarray data sets. UBE4B and EGFR protein levels were measured in patient tumor samples, EGFR degradation rates were measured in neuroblastoma cell lines, and the effects of UBE4B on neuroblastoma tumor cell growth were analyzed. The effects of the EGFR inhibitor cetuximab were examined in neuroblastoma cells that expressed wild‐type and mutant UBE4B.RESULTS:Low UBE4B gene expression is associated with poor outcomes in patients with neuroblastoma. UBE4B overexpression reduced neuroblastoma tumor cell proliferation, and UBE4B expression was inversely related to EGFR expression in tumor samples. EGFR degradation rates correlated with cellular UBE4B levels. Enhanced expression of catalytically active UBE4B resulted in reduced sensitivity to EGFR inhibition.CONCLUSIONS:The current study demonstrates associations between UBE4B expression and the outcomes of patients with neuroblastoma and between UBE4B and EGFR expression in neuroblastoma tumor samples. Moreover, levels of UBE4B influence neuroblastoma tumor cell proliferation, EGFR degradation, and response to EGFR inhibition. These results suggest UBE4B‐mediated growth factor receptor trafficking may contribute to the poor prognosis of patients who have neuroblastoma tumors with 1p36 deletions and that UBE4B expression may be a marker that can predict responses of neuroblastoma tumors to treatment. Cancer 2013. © 2012 American Cancer Society.
Trait‐level and momentary correlates of bulimia nervosa with a history of anorexia nervosa
Authors: Goldschmidt Andrea B. , Peterson Carol B. , Wonderlich Stephen A. , Crosby Ross D. , Engel Scott G. , Mitchell James E. , Crow Scott J. , Cao Li , Berg Kelly C. 
Published: September 2012

AbstractObjective:Some investigators have suggested subtyping bulimia nervosa (BN) by anorexia nervosa (AN) history. We examined trait‐level and momentary eating‐related and psychosocial factors in BN with and without an AN history.Method:Interview, questionnaire, and ecological momentary assessment data of eating‐related and psychological symptoms were collected from 122 women with BN, including 43 with (BN+) and 79 without an AN history (BN−).Results:Body mass index (kg/m2) was lower in BN+ than BN− (p = 0.001). Groups did not differ on trait‐level anxiety, shape/weight concerns, psychiatric comorbidity, or dietary restraint; or on momentary anxiety, dietary restriction, binge eating, purging, or exercise frequency, or affective patterns surrounding binge/purge behaviors. Negative affect increased prior to exercise and decreased thereafter in BN+ but not BN−, although groups did not statistically differ.Discussion:Results do not support formally subtyping BN by AN history. Exercise in BN+ may modulate negative affect, which could have important treatment implications. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2013)
Water‐use response to climate factors at whole tree and branch scale for a dominant desert species in central Asia: Haloxylon ammodendron
Authors: Zheng Chaolei , Wang Quan 
Published: September 2012

ABSTRACTWater use of a dominant desert species, Haloxylon ammodendron, growing in the southern edge of Gurbantünggüt Desert in northwest China, was measured using sap flow technologies at both tree and branch scales. Daily sap flow at whole‐tree scale showed a good relationship with atmospheric evaporation demand (P < 0·001), whereas daily sap flow at branch scale showed good relationships with the variable of transpiration rate (P < 0·01). Hysteresis in hourly sap flow at both scales was observed as a function of micro‐meteorological variables, in which the hysteresis between sap flow and vapour pressure deficit was clockwise rotation, suggesting that the water use of H. ammodendron was related to not just the stomatal behaviour but also use of stored plant water. The hysteresis between sap flow and photosynthetic photon flux density was counter‐clockwise after precipitation, but turned to be clockwise under dry conditions, which was ever clearer at whole‐tree scale. Different responses of sap flows at branch and whole‐tree scale to climate factors were identified, which strongly indicated that H. ammodendron had some mechanisms to reduce whole‐tree water use at high transpiration demand, while maintaining part of canopy under relatively high water use, which resulted in canopy scale patchiness. Copyright © 2012 John Wiley & Sons, Ltd.
Hexagonal Supramolecular Assemblies Based on a RuII(DMSO)3‐ or OsII(DMSO)3‐Capped {HW9O33} Isopolyanion with Potassium Cations as Linkers
Authors: Barats‐Damatov Delina , Shimon Linda J. W. , Neumann Ronny 
Published: September 2012

AbstractCrystallization of the {HW9O33} isopolyanion in the presence of MII(DMSO)4Cl2 (where M = Ru, Os) and Na and K cations yielded one‐dimensional chains, {K[HW9O33M2(C2H6SO)6]6–}n. The {HW9O33} isopolyanion is capped by MII(DMSO)3 moieties, which are, in turn, linked by potassium cations. The chains for the RuII‐based compound show a prismatic coordination around the K+ linker and {HW9O33} moieties that are eclipsed relative to each other along the chain, while the OsII‐based compound has an octahedral coordination around the K+ linker and {HW9O33} moieties that are staggered relative to each other along the chain. The three‐dimensional arrangement of the two compounds is quite different. For the RuII compound, channels are obtained by the arrangement of six {K[HW9O33Ru2(C2H6SO)6]6–}n chains along the c axis. The channel is stabilized by the binding of sodium cations, which interlock the chains through coordination of different oxygen atoms and leads to a tight staggered arrangement between the chains of {K[HW9O33Ru2(C2H6SO)6]6–}n. The channels have an approximate diameter of 8 Å and are occupied by layers of six sodium cations that form chair‐like hexagons with Na–Na interatomic distances of 2.807 Å. There are five water molecules that separate the layers of the Na+ cations. For the osmium compound, two different types of channels, defined by the arrangement three {K[HW9O33Os2(C2H6SO)6]6–}n chains, are formed. The channels are formed through interchain bonding through a bridge formed by connecting sodium atoms to the terminal atoms of the {HW9O33} unit. Here, the {K[HW9O33Os2(C2H6SO)6]6–}n chains are eclipsed relative to one another. Water molecules occupy one channel, while the other channel is occupied by K+ cations hexacoordinated to aqua ligands. The approximate diameter of the channels is 5.5 Å.
Siloxane‐Crown Ether Polyamide Based Electrode for Electrochemical Determination of Lead(II) in Aqueous Solution
Authors: Simionca Ioana‐Maria , Arvinte Adina , Ardeleanu Rodinel , Pinteala Mariana 
Published: September 2012

AbstractA siloxane‐crown ether polyamide copolymer (PDMS‐PA‐DB18C6) was electrochemically investigated for fabrication of lead‐sensitive electrodes for trace analysis in aqueous solutions. The PDMS‐PA‐DB18C6 electrodes were successfully evaluated for anodic stripping voltammetric determination of lead(II) as a promising alternative for the detection of lead at ppb levels. By a judicious choice of the deposition time, electrolyte concentration and pulse amplitude, good analytical performance of the developed sensor could be achieved, with a linear response in the range of 20–700 ppb, when LOD of 3.5 ppb could be attained. This method showed a good degree of selectivity and sensitivity for lead, suitable for the determination of Pb2+ in wastewater sample.
All Solid State Nickel(II)‐Selective Potentiometric Sensor Based on an Upper Rim Substituted Calixarene
Authors: Kumar Pankaj 
Published: September 2012

AbstractA new ionophore, i.e. p‐(2‐thiazolazo)calix[4]arene (I) has been explored for its selective behavior towards Ni(II) ions. A poly(vinyl chloride) based membrane containing (I) as an electroactive material along with sodiumtetraphenylborate (NaTPB), and nitrophenyloctyl ether in the ratio 10 : 100 : 3 : 150 (I:PVC:NaTPB:NPOE) (w/w) was used to fabricate an all solid state nickel(II)‐selective sensor. The developed sensor exhibited a working concentration range of 1.0×10−6–1.0×10−1 M, with a Nernstian slope of 28.9±1.0 mV/decade of activity and a response time of 10–15 s. This sensor shows a detection limit of 9.0×10−7 M. Its potential response remains unaffected of pH in the range 3.0–7.6, and the cell assembly could be used successfully in partially nonaqueous medium (up to 10 % v/v) without any significant change in the slope value or the working concentration range. The sensor worked satisfactorily for about ten weeks and exhibited excellent selectivity over a number of mono‐, bi‐, and tri‐valent cations including alkali, alkaline earth metal, and transition metal ions. It could be used as an indicator electrode for the end point determination in the potentiometric titration of nickel ions against ethylenediaminetetraacetic acid (EDTA) as well as for the determination of nickel ion concentration in real samples.
Hybrid E‐Tongue for the Evaluation of Sweetness and Bitterness of Soft Drinks Fortified with Epigallocatechin Gallate
Authors: Bulbarello Andrea , Cuenca Martha , Schweikert Loni , Mannino Saverio , Scampicchio Matteo 
Published: September 2012

AbstractA home‐made hybrid electronic tongue was set up, validated and applied to discriminate soft drinks fortified with plant extracts of green tea. The e‐tongue consists of a flow injection system equipped with two electrochemical and one optical sensors. Different formulations of soft drinks composed of glucose and epigallocatechin gallate were then discriminated by principal component analysis. Furthermore, two partial least squares regression models were developed to estimate the “sweetness” (r2 of 0.992) and “bitterness” (r2 of 0.993) of the model solutions and commercial soft drinks, before and after their fortification with epigallocatechin gallate.
Determination of Salbutamol in Pharmaceutical and Serum Samples by Adsorptive Stripping Voltammetry on a Carbon Paste Electrode Modified by Iron Titanate Nanopowders
Authors: Attaran Abdol Mohammad , Javanbakht Mehran , Fathollahi Fatemeh , Enhessari Morteza 
Published: September 2012

AbstractThis study introduces a fast and direct electrochemical method for the determination of salbutamol using an iron titanate nanopowder‐modified carbon paste electrode. The electrochemical behavior of salbutamol was studied by differential pulse adsorptive stripping voltammetry. Factors affecting the performance of the adsorptive stripping such as the modifier percent, the electrolyte pH and accumulation time and potential were optimized. The resulting electrode exhibited a linear response in the range of 0.2–25 nM of salbutamol with a detection limit of 90 pM. The proposed method was successfully applied to determine salbutamol in pharmaceutical formulations and human blood plasma.
Identification of upregulated genes in oral squamous cell carcinomas
Authors: Lessa Roberta C. , Campos Antonio Hugo J. F. M. , de Freitas Carlos Elias , da Silva Felipe Rodrigues , Kowalski Luiz Paulo , Carvalho André Lopes , Vettore André Luiz 
Published: September 2012

BackgroundOral cancer is the most common subset of head and neck squamous cell carcinomas (HNSCC). These tumors often have an aggressive clinical outcome hallmarked by a propensity for local invasion and regional nodal metastasis. Upregulated genes could be useful as markers for diagnosis, prognosis, and as new drug targets for these tumors.MethodsTo identify upregulated genes in oral squamous cell carcinomas (OSSCs), we examined the ORESTES public database and used a quantitative reverse transcription–polymerase chain reaction (qRT‐PCR) approach to determine the expression level of selected genes in tumor samples.Results and ConclusionsThe ORESTES data mining analysis indicated 40 upregulated genes in HNSCC. Nine of these candidate genes were selected for further qRT‐PCR validation and 3 of them (ALDOA, AHSA1, and POLQ) were frequently found upregulated in OSCC samples, which may indicate an association of these genes with the carcinogenesis process in this tumor site and they can constitute potential new targets for therapy. © 2012 Wiley Periodicals, Inc. Head Neck 35: 1475–1481, 2013
The HPV test has similar sensitivity but more overdiagnosis than the Pap test—A randomised health services study on cervical cancer screening in Finland
Authors: Malila Nea , Leinonen Maarit , Kotaniemi‐Talonen Laura , Laurila Pekka , Tarkkanen Jussi , Hakama Matti 
Published: September 2012

AbstractWe compared test sensitivity (in terms of prevented cancers) and overdiagnosis (in terms of non‐progressive pre‐invasive lesions) between the human papillomavirus test (HPV test, Hybrid Capture 2) and the traditional Pap test in routine screening for cervical cancer. The design was a randomised (1:1) health services study in Finland with intake between 2003 and 2007. We estimated sensitivity by the incidence method within one screening round. Overdiagnosis was based on the rate of cervical intraepithelial Grade 3 (CIN3) lesions diagnosed at screen and during the following interval. Out of 203,788 randomised women 132,298 attended (65% in both study arms) and 600,753 person‐years accumulated among attenders up to the end of 2010. In all attenders, 34 invasive cervical cancers and 288 CIN3 lesions were diagnosed at screen or during the following interval. The interval cancer incidence was 2.5/105 person‐years (sensitivity 0.87) and 1.4 (sensitivity 0.93) in the HPV arm and Pap test arm, respectively. The rate of CIN3 lesions was 57.1 and 38.8, respectively. In conclusion, sensitivity of HPV testing was similar to that of Pap testing but caused more overdiagnosis. Therefore, implementation of HPV testing needs to be reconsidered especially in countries with well organised programmes.