bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dipolar Rotors Orderly Aligned in Mesoporous Fluorinated Organosilica Architectures
Authors: Bracco Silvia , Beretta Mario , Cattaneo Alice , Comotti Angiolina , Falqui Andrea , Zhao Ke , Rogers Charles , Sozzani Piero 
Published: February 2015

AbstractNew mesoporous covalent frameworks, based on hybrid fluorinated organosilicas, were prepared to realize a periodic architecture of fast molecular rotors containing dynamic dipoles in their structure. The mobile elements, designed on the basis of fluorinated p‐divinylbenzene moieties, were integrated into the robust covalent structure through siloxane bonds, and showed not only the rapid dynamics of the aromatic rings (ca. 108 Hz at 325 K), as detected by solid‐state NMR spectroscopy, but also a dielectric response typical of a fast dipole reorientation under the stimuli of an applied electric field. Furthermore, the mesochannels are open and accessible to diffusing in gas molecules, and rotor mobility could be individually regulated by I2 vapors. The iodine enters the channels of the periodic structure and reacts with the pivotal double bonds of the divinyl‐fluoro‐phenylene rotors, affecting their motion and the dielectric properties.
High‐mechanical‐strength ferrohydrogels with a magnetically dispersed phase as multifunctional crosslinkers
Authors: Zhu Yanzhao , Wu Zhongkui , Lu Hanmin , Yue Zhi 
Published: February 2015

ABSTRACTIn this article, we report a facile strategy for preparing high‐mechanical‐strength ferrohydrogels containing magnetic nanoparticles homodispersed by a thermodynamically stable Pickering emulsion (PE). After the monomers were mixed with the PE, including methacryloxy propyl trimethoxyl silane emulsified by ferric oxide (Fe2O3) nanoparticles as the dispersed phase, hydrogels were synthesized by free‐radical polymerization. In contrast to conventional hydrogels crosslinked by a molecular crosslinker, in our new approach, the magnetic PE particles served as individual, multifunctional crosslinkers. Characterizations of the swelling behavior, the mechanical properties, and other properties indicated that our ferrohydrogels exhibited outstanding physical performances that were superior to those of traditional hydrogels and magnetic responsiveness. These ferrohydrogels may have applications in soft and controllable actuators. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41950.
A poly(γ‐glutamic acid)‐based hydrogel loaded with superoxide dismutase for wound healing
Authors: Zhuang Huahong , Hong Yanhang , Gao Jingchen , Chen Siyuan , Ma Yina , Wang Shufang 
Published: February 2015

ABSTRACTThe purpose of this study was to develop a poly(γ‐glutamic acid) (γ‐PGA)‐based hydrogel loaded with superoxide dismutase (SOD) to accelerate wound healing. First, γ‐PGA was modified with taurine (γ‐PGAS), and then the SOD‐loaded γ‐PGAS/γ‐PGA hydrogel (SOD‐PGAS/PGA‐H) was prepared by cross‐linking of ethylene glycol diglycidyl ether. The swelling behavior and water vapor transmission rate revealed that PGAS/PGA‐H could create a moist environment for wound surface.In vitrokinetics of SOD release showed that SOD released from PGAS/PGA‐H maintained high activity and SOD‐PGAS/PGA‐H effectively scavenged the superoxide anion. The results of our fibroblast proliferation experiments showed that PGAS/PGA‐H had good cytocompatibility. The effects of SOD‐PGAS/PGA‐H on wound healing were examined in a Type I diabetic rat model with full‐thickness wounds. Twenty‐one days after grafted to wounds, SOD‐PGAS/PGA‐H exhibited a higher rate of wound healing than control group and showed increased collagen deposition and epithelialization. SOD‐PGAS/PGA‐H seems to promote better wound healing and thus might be a promising candidate for wound healing management. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2015,132, 42033.
Xanthan gum: A versatile biopolymer for biomedical and technological applications
Authors: Petri Denise F. S. 
Published: February 2015

ABSTRACTXanthan gum is an extracellular polymer produced mainly by the bacteriumXanthomonas campestris. Traditionally it plays an important role in industrial applications as thickener, emulsion stabilizer and it has been added to water‐based drilling fluids due to its pseudoplastic behavior and thermal stability. The structural properties of xanthan in solution can be tuned by the temperature and ionic strength; under high ionic strength or low temperature, xanthan chains are arranged in helical conformation, whereas under low ionic strength or high temperature, xanthan chains are coiled. Xanthan high molecular weight favors the building up of physical and chemical networks, which have been used as carriers for drugs and proteins and as scaffolds for cells. In combination with other polymers xanthan has been applied as excipient in tablets or as supporting hydrogels for drug release applications, particularly due to its acid resistance. The large versatility of xanthan gum opens the possibility for the creation of new architectures and additional applications involving this fascinating polymer. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2015,132, 42035.
In situ dispersion and compatibilization of lignin/epoxidized natural rubber composites: reactivity, morphology and property
Authors: Jiang Can , He Hui , Yao Xiaojie , Yu Peng , Zhou Ling , Jia Demin 
Published: February 2015

ABSTRACTLignin, a naturally occurring polymer, was viewed as a potential substitute of carbon black for reinforcing rubber materials. However, it shows no reinforcing effect if directly mixed with rubber. In this study, lignin was in situ dispersed at submicrometer size and highly compatible with epoxidized natural rubber (ENR) by using a high‐temperature dynamic heat treatment (HTDHT). Rheology analysis indicated that the ring opening reaction between lignin and ENR occurred at 160°C or above, which was further confirmed by infrared spectroscopy. Due to the consumption of acidic groups of lignin by ENR, the retardant vulcanization effect of lignin was weakened. Morphology observation and dynamic mechanical analysis demonstrated the perfect lignin dispersion and the strong interactions between lignin and ENR. The mechanical properties of the lignin/ENR composites were significantly improved by using HTDHT. Compared to the directly mixed rubber composites, the tensile strength and tear strength of the heat treated rubber composites filled with 40 phr lignin were increased by 114% and 23%, respectively. Especially, the 300% modulus of the heat treated rubber composite was increased by ca. 400%. X‐ray diffraction results indicated that the reinforcement of the composites originated from the presence of lignin rather than the strain‐induced crystallization of ENR. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42044.
Synthesis and characterization of sulfonated fluorinated block copolymer membranes with different esterified initiators for DMFC applications
Authors: Guerrero‐Gutiérrez Edward M. A. , Pérez‐Pérez Maritza , Suleiman David 
Published: February 2015

ABSTRACTThis investigation studied the synthesis of ionic membranes composed of a sulfonated poly(styrene‐isobutylene‐styrene) with novel fluoroblock copolymers. These fluoroblock copolymers were synthesized using three different initiators by Atom Transfer Radical Polymerization (ATRP); two fluoroinitiators were obtained from the esterification of 2‐(perfluoroalkyl) ethanol or octafluoro 4‐4′‐biphenol. The third initiator evaluated was 1‐bromoethyl benzene. The resulting block copolymers were characterized using several techniques: Gel Permeation Chromatography, Nuclear Magnetic Resonance, Fourier Transform Infrared Spectroscopy, Ultraviolet Spectroscopy, Thermogravimetric Analysis, and Differential Scanning Calorimetry. Transport properties (e.g., proton conductivity and methanol permeability) were measured to evaluate their performance for direct methanol fuel cell (DMFC). The choice of ATRP initiator was found to have a profound impact on the thermal stability of the different homopolymers and block copolymers studied. In addition, the chemical nature and symmetry of the initiators can lead to different chemical and electronic transitions, which influence the performance of these ionic membranes in applications such as proton exchange membranes for DMFC applications. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42046.
Preparation of pectin‐inorganic composite material as accumulative material of metal ions
Authors: Yamada Masanori , Shiiba Shuka 
Published: February 2015

ABSTRACTPectin is one of the biopolymers in the cell walls of all plant tissues, but the pectin‐containing materials have been discarded as industrial waste in food‐processing factories. We prepared a water‐insoluble pectin‐inorganic composite material by mixing pectin and a silane coupling reagent, bis(3‐trimethoxysilylpropyl)amine. The mechanical strength of the pectin‐inorganic composite material was higher than that of the pectin material without the addition of an inorganic component. In addition, the thermal stability of the composite material increased with the addition of the inorganic component. Furthermore, when the pectin‐inorganic composite materials were incubated in an aqueous solution of Cu(II), Zn(II), or In(III), these composite materials effectively accumulated not only the heavy metal ions, but also rare‐earth metal ions. Additionally, based on the infrared (IR) measurements, the metal ion accumulative mechanism into the composite material is described. As a result, the IR spectra suggested an electrostatic interaction between the metal ion and carboxy group in the pectin. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42056.
Highly Selective In Vivo Imaging of Endogenous/Exogenous Phosphate Ion over ATP and PPi
Authors: Zhang Jun Feng , Guo Lin E , Zang Tie Nan , Duan Yu Lian , Liu Xin Yi , Yang Zhigang , Verwilst Peter , Luo Kaijun , Wang Guang Ke , Kou Jun Feng , Zhou Ying , Kim Jong Seung 
Published: February 2015

AbstractA chemodosimeter was designed to function as a highly selective phosphate ion (Pi) sensor, showing a 91‐fold ratiometric fluorescence enhancement. The probe successfully visualized exogenous and endogenous apyrase‐catalyzed Pi generation and was the first probe able to trace the generation and enrichment of Pi through hemichannel closure in Sf9 cells.
Influenza virus‐like particles engineered by protein transfer with tumor‐associated antigens induces protective antitumor immunity
Authors: Patel Jaina M. , Vartabedian Vincent F. , Kim Min‐Chul , He Sara , Kang Sang‐Moo , Selvaraj Periasamy 
Published: February 2015

ABSTRACTDelivery of antigen in particulate form using either synthetic or natural particles induces stronger immunity than soluble forms of the antigen. Among naturally occurring particles, virus‐like particles (VLPs) have been genetically engineered to express tumor‐associated antigens (TAAs) and have shown to induce strong TAA‐specific immune responses due to their nano‐particulate size and ability to bind and activate antigen‐presenting cells. In this report, we demonstrate that influenza VLPs can be modified by a protein transfer technology to express TAAs for induction of effective antitumor immune responses. We converted the breast cancer HER‐2 antigen to a glycosylphosphatidylinositol (GPI)‐anchored form and incorporated GPI‐HER‐2 onto VLPs by a rapid protein transfer process. Expression levels on VLPs depended on the GPI‐HER‐2 concentration added during protein transfer. Vaccination of mice with protein transferred GPI‐HER‐2‐VLPs induced a strong Th1 and Th2‐type anti‐HER‐2 antibody response and protected mice against a HER‐2‐expressing tumor challenge. The Soluble form of GPI‐HER‐2 induced only a weak Th2 response under similar conditions. These results suggest that influenza VLPs can be enriched with TAAs by protein transfer to develop effective VLP‐based subunit vaccines against cancer without chemical or genetic modifications and thus preserve the immune stimulating properties of VLPs for easier production of antigen‐specific therapeutic cancer vaccines. Biotechnol. Bioeng. 2015;112: 1102–1110. © 2015 Wiley Periodicals, Inc.
Annotation of additional evolutionary conserved microRNAs in CHO cells from updated genomic data
Authors: Diendorfer Andreas B. , Hackl Matthias , Klanert Gerald , Jadhav Vaibhav , Reithofer Manuel , Stiefel Fabian , Hesse Friedemann , Grillari Johannes , Borth Nicole 
Published: February 2015

ABSTRACTMicroRNAs are small non‐coding RNAs that play a critical role in post‐transcriptional control of gene expression. Recent publications of genomic sequencing data from the Chinese Hamster (CGR) and Chinese hamster ovary (CHO) cells provide new tools for the discovery of novel miRNAs in this important production system. Version 20 of the miRNA registry miRBase contains 307 mature miRNAs and 200 precursor sequences for CGR/CHO. We searched for evolutionary conserved miRNAs from miRBase v20 in recently published genomic data, derived from Chinese hamster and CHO cells, to further extend the list of known miRNAs. With our approach we could identify several hundred miRNA sequences in the genome. For several of these, the expression in CHO cells could be verified from multiple next‐generation sequencing experiments. In addition, several hundred unexpressed miRNAs are awaiting further confirmation by testing for their transcription in different Chinese hamster tissues. Biotechnol. Bioeng. 2015;112: 1488–1493. © 2015 The Authors. Biotechnology and Bioengineering Published by Wiley Periodicals, Inc.
Formulation of Highly Functionalizable DNA Nanoparticles Based on 1,2‐Dithiolane Derivatives
Authors: Charrat Coralie , Biscotti Anaïs , Godeau Guilhem , Greiner Jacques , Vierling Pierre , Guigonis Jean‐Marie , Di Giorgio Christophe 
Published: February 2015

AbstractWe describe the formulation of synthetic virus models based on ionic compounds bearing the polymerizable 1,2‐dithiolane moiety. First, cationic amphiphiles containing the polymeric inducer were prepared and used to efficiently condense a DNA plasmid (pDNA) into a highly monodisperse population of small polymeric cationic DNA nanoparticles (NPs; Dh∼100 nm). These nonspecific cationic particles were then functionalized with anionic PEGylated conjugates, also based on the 1,2‐dithiolane motifs, in order to produce stable and fully dispersible stealth DNA nanoparticles. Our results show that both ionic interactions and polymerization based on the 1,2‐dithiolane pattern occur and that they produce highly functionalizable nonviral DNA NPs.
N‐Glycosylation with Synthetic Undecaprenyl Pyrophosphate‐Linked Oligosaccharide to Oligopeptides by PglB Oligosaccharyltransferase from Campylobacter jejuni
Authors: Ishiwata Akihiro , Taguchi Yuya , Lee Yong Joo , Watanabe Taisuke , Kohda Daisuke , Ito Yukishige 
Published: February 2015

AbstractThe oligosaccharyltransferase PglB from Campylobacter jejuni catalyses the N‐glycosylation reaction with undecaprenyl‐pyrophosphate‐linked Glc1GalNAc5Bac1 (Und‐PP‐Glc1GalNAc5Bac1). Experiments using chemically synthesized donors coupled to fluorescently tagged peptides confirmed that biosynthetic intermediate Und‐PP‐Bac1 and Und‐PP‐GalNAc2Bac1 are transferred efficiently to the Asn residue in the consensus sequence (D/E‐X′‐N‐X‐T/S, X′,X≠P). The products were analyzed in detail by tandem MS to confirm their chemical structures.
Selective Synthesis of Primary Amines by Reductive Amination of Ketones with Ammonia over Supported Pt catalysts
Authors: Nakamura Yoichi , Kon Kenichi , Touchy Abeda Sultana , Shimizu Ken‐ichi , Ueda Wataru 
Published: February 2015

AbstractSupported platinum catalysts are studied for the reductive amination of ketones under ammonia and hydrogen. For a model reaction with 2‐adamantanone, Pt‐loaded MoOx/TiO2 (Pt‐MoOx/TiO2) shows the highest yield of primary amine. The catalyst is effective for the selective transformation of various aliphatic and aromatic ketones to the corresponding primary amines, which demonstrates the first example of the selective synthesis of primary amines by this reaction. The yield of the amine increases with increase in the negative shift of the CO stretching band in the infrared spectra of adsorbed acetone on the catalysts, suggesting that Lewis acid sites on the support material play an important role in this catalytic system.
Bone‐Targeted Cisplatin‐Complexed Poly(γ‐benzyl‐L‐glutamate)–Poly(glutamic acid) Block Polymer Nanoparticles: An Electrochemical Approach
Authors: de Miguel Laura , Cebrián‐Torrejón Gerardo , Caudron Eric , Arpinati Ludovica , Doménech‐Carbó Antonio , Ponchel Gilles 
Published: February 2015

AbstractThe voltammetric response of different osteotropic multifunctional nanoparticles based on cisplatin‐complexed poly(γ‐benzyl‐L‐glutamate)–poly(glutamic acid) block polymer (CDDP‐PBLG‐b‐PGlu) copolymer, with or without poly(γ‐benzyl‐L‐glutamate)–poly(ethylene glycol) block polymer (PBLG‐b‐PEG), and having bone‐targeting properties is studied at biologically relevant pH. Significant differences in the cisplatin‐centered voltammetric signals allow monitoring of the association of cisplatin to nanoparticles as well as release kinetics from them, in agreement with atomic absorption spectroscopy data. Electrochemical studies reveal that the cisplatin association is significant only if the proportion of the PBLG‐b‐PGlu copolymer was greater than PBLG‐b‐PEG.
Electrochemical Conversion of Dichloroacetic Acid to Chloroacetic Acid in a Microfluidic Stack and in a Series of Microfluidic Reactors
Authors: Scialdone Onofrio , Galia Alessandro , Sabatino Simona , Mira Domenico , Amatore Christian 
Published: February 2015

AbstractThe electrochemical conversion of dichloroacetic acid into chloracetic acid is performed in three different microdevices: a simple microfluidic cell; a microfluidic stack equipped with various electrode chambers in series and three microfluidic cells in series. The synthesis of chloracetic acid is performed successfully at low cell potentials without supporting electrolyte with high yields and selectivity under a single‐pass mode. Optimization of the productivity and of the final concentration of the target product is achieved by using a stack with two or three electrode chambers in series. Using three microreactors in series offers interesting new perspectives, including the opportunity to modulate the current density among the reactors chain in order to optimize the figures of merit of the overall process. The effect of various operating parameters such as the initial concentration of dichloroacetic acid, the flow rate and the current density are also presented in detail.
First‐Row Transition‐Metal–Diborane and –Borylene Complexes
Authors: Sharmila Dudekula , Mondal Bijan , Ramalakshmi Rongala , Kundu Sangita , Varghese Babu , Ghosh Sundargopal 
Published: February 2015

AbstractA combined experimental and quantum chemical study of Group 7 borane, trimetallic triply bridged borylene and boride complexes has been undertaken. Treatment of [{Cp*CoCl}2] (Cp*=1,2,3,4,5‐pentamethylcyclopentadienyl) with LiBH4⋅thf at −78 °C, followed by room‐temperature reaction with three equivalents of [Mn2(CO)10] yielded a manganese hexahydridodiborate compound [{(OC)4Mn}(η6‐B2H6){Mn(CO)3}2(μ‐H)] (1) and a triply bridged borylene complex [(μ3‐BH)(Cp*Co)2(μ‐CO)(μ‐H)2MnH(CO)3] (2). In a similar fashion, [Re2(CO)10] generated [(μ3‐BH)(Cp*Co)2(μ‐CO)(μ‐H)2ReH(CO)3] (3) and [(μ3‐BH)(Cp*Co)2(μ‐CO)2(μ‐H)Co(CO)3] (4) in modest yields. In contrast, [Ru3(CO)12] under similar reaction conditions yielded a heterometallic semi‐interstitial boride cluster [(Cp*Co)(μ‐H)3Ru3(CO)9B] (5). The solid‐state X‐ray structure of compound 1 shows a significantly shorter boron–boron bond length. The detailed spectroscopic data of 1 and the unusual structural and bonding features have been described. All the complexes have been characterized by using 1H, 11B, 13C NMR spectroscopy, mass spectrometry, and X‐ray diffraction analysis. The DFT computations were used to shed light on the bonding and electronic structures of these new compounds. The study reveals a dominant BHMn, a weak BBMn interaction, and an enhanced BB bonding in 1.
Tuning the Basicity of Cyano‐Containing Ionic Liquids to Improve SO2 Capture through Cyano–Sulfur Interactions
Authors: Cui Guokai , Zhang Fengtao , Zhou Xiuyuan , Li Haoran , Wang Jianji , Wang Congmin 
Published: February 2015

AbstractA new approach has been developed to improve SO2 sorption by cyano‐containing ionic liquids (ILs) through tuning the basicity of ILs and cyano–sulfur interaction. Several kinds of cyano‐containing ILs with different basicity were designed, prepared, and used for SO2 capture. The interaction between these cyano‐containing ILs and SO2 was investigated by FTIR and NMR methods. Spectroscopic investigations and quantum chemical calculations showed that dramatic effects on SO2 capacity originate from the basicity of the ILs and enhanced cyano–sulfur interaction. Furthermore, the captured SO2 was easy to release by heating or bubbling N2 through the ILs. This efficient and reversible process, achieved by tuning the basicity of ILs, is an excellent alternative to current technologies for SO2 capture.
Encapsulation of an Interpenetrated Diamondoid Inorganic Building Block in a Metal–Organic Framework
Authors: Zhang Huabin , Lin Ping , Chen Erxia , Tan Yanxi , Wen Tian , Aldalbahi Ali , Alshehri Saad M. , Yamauchi Yusuke , Du Shaowu , Zhang Jian 
Published: February 2015

AbstractThe first example of an inorganic–organic composite framework with an interpenetrated diamondoid inorganic building block, featuring unique {InNa}n helices and {In12Na16} nano‐rings, has been constructed and structurally characterized. This framework also represents a unique example of encapsulation of an interpenetrated diamondoid inorganic building block in a metal–organic framework.
Vanadium(V) Oxo and Imido Calix[8]arene Complexes: Synthesis, Structural Studies, and Ethylene Homo/Copolymerisation Capability
Authors: Redshaw Carl , Walton Mark J. , Lee Darren S. , Jiang Chengying , Elsegood Mark R. J. , Michiue Kenji 
Published: February 2015

AbstractInteraction of p‐tert‐butylcalix[8]areneH8 (L8H8) with [NaVO(OtBu)4] (formed in situ from VOCl3) afforded the complex [Na(NCMe)5][(VO)2L8H]⋅4 MeCN (1⋅4 MeCN). Increasing [NaVO(OtBu)4] to 4 equiv led to [Na(NCMe)6]2[(Na(VO)4L8)(Na(NCMe))3]2⋅10 MeCN (2⋅10 MeCN). With adventitious oxygen, reaction of 4 equiv of [VO(OtBu)3] with L8H8 afforded the alkali‐metal‐free complex [(VO)4L8(μ3‐O)2] (3); solvates 3⋅3 MeCN and 3⋅3 CH2Cl2 were isolated. For the lithium analogue, the order of addition had to be reversed such that lithium tert‐butoxide was added to L8H8 and then treated with 2 equiv of VOCl3; crystallisation afforded [(VO2)2Li6[L8](thf)2(OtBu)2(Et2O)2]⋅Et2O (4⋅Et2O). Upon extraction into acetonitrile, [Li(NCMe)4][(VO)2L8H]⋅8 MeCN (5⋅8 MeCN) was formed. Use of the imido precursors [V(NtBu)(OtBu)3] and [V(Np‐tolyl)(OtBu)3] and L8H8, afforded [tBuNH3][{V(p‐tolylN)}2L8H]⋅3 1/2 MeCN (6⋅3 1/2 MeCN). The molecular structures of 1 to 6 are reported. Complexes 1, 3, and 4 were screened as precatalysts for the polymerisation of ethylene in the presence of cocatalysts at various temperatures and for the copolymerisation of ethylene with propylene. Activities as high as 136 000 g (mmol(V) h)−1 were sometimes achieved; higher molecular weight polymers could be obtained versus the benchmark [VO(OEt)Cl2]. For copolymerisation, incorporation of propylene was 7.1–10.9 mol % (compare 10 mol % for [VO(OEt)Cl2]), although catalytic activities were lower than [VO(OEt)Cl2].