bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Lewis Acid Mediated Diastereoselective Intermolecular Radical Addition/Trapping with Pyrazolidinone Acrylimides.
Authors: Ma Gaoyuan , Fujita Takehiro , Sibi Mukund P. 
Published: September 2015

AbstractA facile one‐pot procedure for the radical conjugate addition of alkyl iodides to amides bearing a new pyrazolidinone chiral auxiliary and subsequent diastereoselective trapping of the intermediate radical by an allyl group is developed.
ChemInform Abstract: In situ Generation of Difluoromethyl Diazomethane for [3 + 2] Cycloadditions with Alkynes.
Authors: Mykhailiuk Pavel K. 
Published: September 2015

AbstractDifluoromethyl diazomethane is generated in situ and utilized in [3 + 2] cycloadditions for the first time.
ChemInform Abstract: Synthesis of 2‐Bromoimidazoles from Alkynes, N‐Sulfonylazides, and Bromocyanides.
Authors: Lee Eunsook , Ryu Taekyu , Shin Eunji , Son Jeong‐Yu , Choi Wonseok , Lee Phil Ho 
Published: September 2015

AbstractThe title compounds are obtained by Rh‐catalyzed cyclization of triazoles with bromocyanide (II).
ChemInform Abstract: Preparation and Diels—Alder Reactions of 1′‐Heterosubstituted Vinylimidazoles.
Authors: Ray Abhisek , Mukherjee Sabuj , Das Jayanta , Bhandari Manoj K. , Du Hongwang , Yousufuddin Muhammed , Lovely Carl J. 
Published: September 2015

AbstractThe preparation of halogen, silyl or stannyl substituted vinylimidazoles is developed and their Diels—Alder reaction with N‐phenylmaleimide is found to give tricyclic products, however with slightly different structural results.
ChemInform Abstract: Nickel‐Catalyzed Decarboxylative Arylation of Azoles with Perfluoro‐ and Nitrobenzoates.
Authors: Crawford Jennifer M. , Shelton Kyle E. , Reeves Emily K. , Sadarananda Bryce K. , Kalyani Dipannita 
Published: September 2015

AbstractThe title process allows the synthesis of 2‐arylated benzoxazoles.
ChemInform Abstract: A Straightforward Metal‐Free Synthesis of 2‐Substituted Thiazolines in Air.
Authors: Trose Michael , Lazreg Faima , Lesieur Mathieu , Cazin Catherine S. J. 
Published: September 2015

AbstractThe title thiazolines (III) (25 examples) are obtained by base‐catalyzed reaction of various nitriles (I) and cysteamine hydrochloride (II) under solvent‐free conditions.
ChemInform Abstract: A Facile Approach to Synthesize 3,5‐Disubstituted‐1,2,4‐oxadiazoles via Copper‐Catalyzed‐Cascade Annulation of Amidines and Methylarenes.
Authors: Guo Wei , Huang Kunbo , Ji Fanghua , Wu Wanqing , Jiang Huanfeng 
Published: September 2015

AbstractA novel straightforward synthesis of disubstituted‐1,2,4‐oxadiazoles by the copper‐catalyzed reaction of amidines with methylarenes is reported.
ChemInform Abstract: One‐Pot Multicomponent Synthesis of Highly Functionalized Bio‐Active Pyrano[2,3‐c]pyrazole and Benzylpyrazolyl Coumarin Derivatives Using ZrO2 Nanoparticles as a Reusable Catalyst.
Authors: Saha Arijit , Payra Soumen , Banerjee Subhash 
Published: September 2015

AbstractThe catalyst is reusable up to ten cycles without loss of catalytic activity and its tetragonal plane.
ChemInform Abstract: Copper(I) Iodide Supported Synthesis of Coumarin‐ and Quinolone‐Annulated 2‐Aminothiazoles.
Authors: Paul Satya B. , Majumdar K. C. , Anwar Siddique , Choudhury Sudip 
Published: September 2015

AbstractAn efficient, low‐hazard protocol for the reaction of coumarin and quinolone derivatives with phenylthiocyanates is presented.
ChemInform Abstract: ortho‐Quinone Methides as Reactive Intermediates in Asymmetric Broensted Acid Catalyzed Cycloadditions with Unactivated Alkenes by Exclusive Activation of the Electrophile.
Authors: Hsiao Chien‐Chi , Raja Sadiya , Liao Hsuan‐Hung , Atodiresei Iuliana , Rueping Magnus 
Published: September 2015

AbstractThe [4 + 2]‐hetero‐Diels—Alder reaction tolerates a broad range of alkenes including 1‐substituted and acyclic as well as cyclic 1,2‐disubstituted ones which react according to the title reaction to form chromanes with two stereocenters with excellent diastereoselectivity and enantioselectivity.
ChemInform Abstract: Radical 5‐exo Cyclization of Alkynoates with 2‐Oxoacetic Acids for Synthesis of 3‐Acylcoumarins.
Authors: Liu Tong , Ding Qiuping , Zong Qianshou , Qiu Guanyinsheng 
Published: September 2015

AbstractThe protocol represents the first example for coumarin synthesis from alkynoates through decarboxylative radical 5‐exo annulation and ester migration.
ChemInform Abstract: Sc(OTf)3‐Catalyzed [3 + 3] Annulation of Cyclopropane 1,1‐Diesters with Mercaptoacetaldehyde: A Facile Strategy for the Synthesis of Tetrahydrothiopyranols.
Authors: Wang Hua‐Peng , Zhang Huan‐Huan , Hu Xiu‐Qin , Xu Peng‐Fei , Luo Yong‐Chun 
Published: September 2015

AbstractA Sc(OTf)3‐catalyzed formal [3 + 3] cycloaddition of cyclopropane dicarboxylates with mercaptoacetaldehyde is developed to produce tetrahydrothiopyranols in good yields.
ChemInform Abstract: An Environmentally Benign Catalytic Method for Versatile Synthesis of 1,4‐Dihydropyridines via Multicomponent Reactions.
Authors: Cao Shuo , Zhong Shanshan , Hu Changfeng , Wan Jie‐Ping , Wen Chengping 
Published: September 2015

AbstractTitle compounds [(IV) and (VI)] are synthesized through environmentally benign multicomponent reactions in aqueous medium using lactic acid as a green catalyst.
ChemInform Abstract: Chromium(II)‐Catalyzed Amination of N‐Heterocyclic Chlorides with Magnesium Amides.
Authors: Steib Andreas K. , Fernandez Sarah , Kuzmina Olesya M. , Corpet Martin , Gosmini Corinne , Knochel Paul 
Published: September 2015

AbstractThe ligand‐free chromium dichloride‐catalyzed selective amination of mono‐ and dichlorinated pyridines, quinolines, isoquinolines, and quinoxalines with various amines is reported.
ChemInform Abstract: Ni(II)/BINOL‐Catalyzed Alkenylation of Unactivated C(sp3)—H Bonds.
Authors: Liu Yue‐Jin , Zhang Zhuo‐Zhuo , Yan Sheng‐Yi , Liu Yan‐Hua , Shi Bing‐Feng 
Published: September 2015

AbstractThe gained olefins can serve as versatile handles for further preparations.
ChemInform Abstract: Copper‐Catalyzed Cascade Addition Route to 2,3,4‐Trisubstituted Quinoline Derivatives.
Authors: Crifar Cynthia , Doerr Aurelie A. , Lubell William D. 
Published: September 2015

AbstractThe copper‐catalyzed cascade addition of vinylmagnesium bromide on methyl anthranilate without amine protection affords ketone (III) which undergoes the Friedlnder reaction with various ketones to give trisubstituted quinolines.
ChemInform Abstract: Facile Synthesis of Acridines via Pd(0)‐Diphosphine Complex‐Catalyzed Tandem Coupling/Cyclization Protocol.
Authors: Wang Ting‐Jun , Chen Wen‐Wen , Li Yi , Xu Ming‐Hua 
Published: September 2015

AbstractCyclization of 2‐bromobenzaldehydes with anilines easily affords a broad range of acridines.
ChemInform Abstract: The α‐Chymotrypsin‐Catalyzed Povarov Reaction: One‐Pot Synthesis of Tetrahydroquinoline Derivatives.
Authors: Li Ling‐Po , Cai Xin , Xiang Yang , Zhang Yong , Song Jian , Yang Da‐Cheng , Guan Zhi , He Yan‐Hong 
Published: September 2015

AbstractA wide range of the title compounds (IV)/(V), (VIII)/(IX) are obtained by one‐pot three‐component Povarov reaction using α‐chymotrypsin from bovine pancreas as safe, economical, and eco‐friendly catalyst.
ChemInform Abstract: Modified Multicomponent Biginelli—Atwal Reaction Towards a Straightforward Construction of 5,6‐Dihydropyrimidin‐4‐ones.
Authors: Pair Etienne , Levacher Vincent , Briere Jean‐Francois 
Published: September 2015

AbstractThe title dihydropyrimidinones are synthesized as racemic mixtures or enantiopure diastereomers (IX) by multicomponent Knoevenagel‐aza‐Michael‐cyclocondensation reaction of Meldrum′s acid, isourea derivatives, and various aldehydes.
ChemInform Abstract: Copper‐Powder‐Catalyzed Synthesis of Pyrimidines from β‐Bromo α,β‐Unsaturated Ketones and Amidine Hydrochlorides.
Authors: Jiao Yang , Ho Son Long , Cho Chan Sik 
Published: September 2015

AbstractThe reaction provides a new method for synthesizing pyrimidines starting from readily available ketones and amidine hydrochloride.
ChemInform Abstract: Synthesis of Fused Polyhalogeno‐7a‐hydroxy‐[1,2‐a]indol‐5‐one Derivatives.
Authors: Yu Fu‐Chao , Hao Xiao‐Pan , Lin Xin‐Rong , Yan Sheng‐Jiao , Lin Jun 
Published: September 2015

AbstractBased on Nenitzescu indole synthesis, the title derivatives [e.g. (III)] are synthesized from heterocyclic ketene aminals [e.g. (I)] and halogenated quinones [e.g. (II)] without catalyst in acetone at room temperature.
ChemInform Abstract: Highly Regio‐ and Stereoselective Hydrosilylation of Internal Thioalkynes under Mild Conditions.
Authors: Ding Shengtao , Song Li‐Juan , Wang Yong , Zhang Xinhao , Chung Lung Wa , Wu Yun‐Dong , Sun Jianwei 
Published: September 2015

AbstractThe title reaction is based on the addition of sterically congested (Tms‐O)3SiH onto a range of thioalkynes bearing aryl and alkyl substituents endowed with various functional groups.
ChemInform Abstract: Synthesis of Quaternary α‐Hydroxy Phosphonates via Direct Hydroxylation of Phosphonate Compounds.
Authors: Liu Jiyan , Wang Wei , Wang Rui , Gu Lijun 
Published: September 2015

AbstractQuaternary α‐hydroxy phosphonates (II) are efficiently synthesized by direct hydroxylation reaction of phosphonates (I) under mild conditions.
ChemInform Abstract: A Novel, Rapid and Green Method of Phosphorylation under Ultrasound Irradiation and Catalyst Free Conditions.
Authors: Bouzina Abdeslem , Belhani Billel , Aouf Nour‐Eddine , Berredjem Malika 
Published: September 2015

AbstractVarious N‐acylamines (I), N‐acylaminoester ((S)‐IV), N‐acylaminoalcohols ((S)‐VIII), and N‐acylsulfonamides (X) are efficiently phosphorylated with trialkylphosphite under ultrasound irradiation conditions furnishing corresponding amidophosphonates in high yield.
ChemInform Abstract: Sandensone A, a Novel Sesquiterpenoid from the Formosan Soft Coral Sinularia sandensis
Authors: Cheng Shi‐Yie , Wang Shang‐Kwei , Chen Pei‐Wen , Duh Chang‐Yih 
Published: September 2015

Abstractisolation, structure elucidation and cytotoxicity
ChemInform Abstract: Modular Stereoselective Synthesis of (1→2)‐C‐Glycosides Based on the sp2—sp3 Suzuki—Miyaura Reaction.
Authors: Oroszova Beata , Choutka Jan , Pohl Radek , Parkan Kamil 
Published: September 2015

AbstractThe key step comprises a Ni‐catalyzed cross‐coupling reaction of D‐glucal pinacol boronate with alkylbromide or alkyliodide glycoside, thus representing the first example for a challenging sp2—sp3 cross‐coupling in carbohydrate chemistry.
ChemInform Abstract: Direct Glycosylation of Unprotected and Unactivated Sugars Using Bismuth Nitrate Pentahydrate.
Authors: Polanki Innaiah K. , Kurma Siva H. , Bhattacharya Asish K. 
Published: September 2015

AbstractBismuth nitrate pentahydrate acts as an effective catalyst for the glycosylation of unactivated sugars (examples for the reaction of 5 sugars with 9 alcohols are given).
ChemInform Abstract: Synthesis and Study of N‐Acetyl D‐Glucosamine Triazole Derivatives as Effective Low Molecular Weight Gelators.
Authors: Mangunuru Hari P. R. , Yerabolu Jayasudhan Reddy , Wang Guijun 
Published: September 2015

Abstract1,3‐Dipolar cycloaddition of azide (I) with alkynes provides the title triazoles (III), of which products (IIIa,b,e) are able to function as organo gelators for various solvents.
ChemInform Abstract: Geranylated Flavanones from Paulownia coreana and Their Inhibitory Effects on Nitric Oxide Production.
Authors: Jin Qinghao , Lee Chul , Lee Jin Woo , Lee Dongho , Kim Youngsoo , Hong Jin Tae , Kim Jin Sook , Kim Joo‐Hwan , Lee Mi Kyeong , Hwang Bang Yeon 
Published: September 2015

AbstractA new geranylated flavone (I) is isolated along with ten known compounds.
ChemInform Abstract: Structure, Absolute Configuration, and Conformational Study of Resorcylic Acid Derivatives and Related Congeners from the Fungus Penicillium brocae.
Authors: Zhang Peng , Meng Ling‐Hong , Mandi Attila , Li Xiao‐Ming , Kurtan Tibor , Wang Bin‐Gui 
Published: September 2015

AbstractOne new resorcylic acid derivative (IV), and five new loop‐opened resorcylic acid‐related congeners, including brocapyrone A (III), and brocaketones A‐D (structure examples (I) and (II)) are isolated together with three known compounds.
ChemInform Abstract: Mexicanolide Limonoids with in vitro Neuroprotective Activities from Seeds of Khaya senegalensis.
Authors: Li Hui , Li Yi , Wang Xiao‐Bing , Pang Tao , Zhang Lu‐Yong , Luo Jun , Kong Ling‐Yi 
Published: September 2015

AbstractFourteen new mexicanolide‐type limonoids, khasenegasins A‐N (structure example (I)) are isolated together with three known compounds i.e.
ChemInform Abstract: Synthesis of Manganese Dioxide/Iron Oxide/Graphene Oxide Magnetic Nanocomposites for Hexavalent Chromium Removal.
Authors: Liu Yan , Luo Chao , Cui Guijia , Yan Shiqiang 
Published: September 2015

AbstractMnO2/Fe3O4/graphene oxide (GO) and MnO2/Fe3O4/graphene nanocomposites are prepared by a two‐step reaction involving solvothermal reaction of an ultrasonicated dispersion of graphene oxide and Fe(acac)3 in ethylene glycol with and without the addition of N2H4 hydrate (autoclave, 180 °C, 16 h) followed by MnO2 coating in an KMnO4 aqueous solution (circulator, 80 °C, 3 h, pH 5 and pH 2).
ChemInform Abstract: Ethynyl Benziodoxolone (EBX): Installing Alkynes the Reversed Way
Authors: Kaschel Johannes , Werz Daniel B. 
Published: September 2015

AbstractReview: use of the hypervalent iodine reagent EBX (ethynyl benziodoxolone) for the electrophilic introduction of alkynes; 17 refs.
ChemInform Abstract: Synthetic Methods of α‐Pyridinyl and α‐Bipyridinyl Alcohols and α,α′‐Pyridine and α,α′‐Bipyridine Diols
Authors: Tolea Tt , Jordaana J. H. L. , Vosloo H. C. M. 
Published: September 2015

AbstractReview: 263 refs.
ChemInform Abstract: Electrochromic and Unique Chiroptical Properties of Helically Deformed Tetraarylquinodimethanes Generated from Less‐Hindered Dicationic Precursors Upon Reduction
Authors: Suzuki Takanori , Sakano Yuto , Iwai Tomohiro , Iwashita Shinichi , Miura Youhei , Katoono Ryo , Kawai Hidetoshi , Fujiwara Kenshu , Tsuji Yasushi , Fukushima Takanori 
Published: September 2015

AbstractReview: 23 refs.
Suspicious cytologic diagnostic category in endoscopic ultrasound‐guided FNA of the pancreas: Follow‐up and outcomes
Authors: Alston Evan A. , Bae Sejong , Eltoum Isam A. 
Published: September 2015

BACKGROUNDThe objective of the current study was to assess how the suspicious category is followed up in a large endoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) service, its outcomes, and the predictors that are likely to be associated with the subsequent diagnosis of a neoplastic process.METHODSFor pancreatic EUS‐FNA samples with the suspicious category diagnosis, the authors reviewed the electronic medical record for the method of follow‐up and the risks associated with pancreatic malignancy. Logistic regression analysis was used to determine the risk factors that were likely to be associated with the diagnosis of a neoplastic lesion after a cytologic diagnosis of “suspicious.”RESULTSOf a total of 3832 EUS‐FNA cases, 116 were diagnosed with suspicious cytology. A total of 90 of 98 neoplasms (92%) were identified, including 72 carcinomas (73%). Similar rates of neoplasia were detected after repeat FNA (34 of 37 neoplasms [92%]) and subsequent biopsy/surgical resection (44 of 46 neoplasms [96%]), but significantly fewer neoplasms were detected among patients with clinical follow‐up (18 of 23 neoplasms [78%]). On multivariate analysis of the potential predictive variables listed above, the presence of a mass was found to be significantly associated with a higher rate of diagnosis of a neoplasm, whereas weight loss was significantly associated with a diagnosis of carcinoma.CONCLUSIONSThe diagnostic category of “suspicious” is associated with a high risk of benign and malignant neoplasms, regardless of the method of follow‐up. The presence of a mass and weight loss are significant predictors of a subsequent diagnosis of a neoplasm after suspicious cytology. In patients with suspicious cytology and these findings, surgery is recommended for resectable masses and repeat FNA for unresectable masses. Cancer (Cancer Cytopathol) 2016;124:53–57. © 2015 American Cancer Society.
Synthesis of a Sulfonated Two‐Dimensional Covalent Organic Framework as an Efficient Solid Acid Catalyst for Biobased Chemical Conversion
Authors: Peng Yongwu , Hu Zhigang , Gao Yongjun , Yuan Daqiang , Kang Zixi , Qian Yuhong , Yan Ning , Zhao Dan 
Published: September 2015

AbstractBecause of limited framework stability tolerance, de novo synthesis of sulfonated covalent organic frameworks (COFs) remains challenging and unexplored. Herein, a sulfonated two‐dimensional crystalline COF, termed TFP‐DABA, was synthesized directly from 1,3,5‐triformylphloroglucinol and 2,5‐diaminobenzenesulfonic acid through a previously reported Schiff base condensation reaction, followed by irreversible enol‐to‐keto tautomerization, which strengthened its structural stability. TFP‐DABA is a highly efficient solid acid catalyst for fructose conversion with remarkable yields (97 % for 5‐hydroxymethylfurfural and 65 % for 2,5‐diformylfuran), good chemoselectivity, and good recyclability. The present study sheds light on the de novo synthesis of sulfonated COFs as novel solid acid catalysts for biobased chemical conversion.
Angiopoietin‐2 in acute myocardial infarction complicated by cardiogenic shock—a biomarker substudy of the IABP‐SHOCK II‐Trial
Authors: Pöss Janine , Fuernau Georg , Denks Daniel , Desch Steffen , Eitel Ingo , de Waha Suzanne , Link Andreas , Schuler Gerhard , Adams Volker , Böhm Michael , Thiele Holger 
Published: September 2015

AimsAngiopoietin‐2 (Ang‐2) is a mediator of capillary leakage, and increased Ang‐2 levels were associated with poor in‐hospital outcome in a pilot study in cardiogenic shock (CS). In this larger study, we followed this hypothesis and aimed at assessing the predictive role of Ang‐2 on short‐ and long‐term mortality, investigating the effect of intra‐aortic balloon pump (IABP) treatment on Ang‐2 levels, and identifying clinical and procedural predictors of increased Ang‐2.Methods and resultsIn the IABP‐SHOCK II‐trial, 600 patients with CS complicating acute myocardial infarction were assigned to therapy with or without IABP. This substudy included 189 randomized patients with serial blood sampling performed at days 1, 2, and 3. No significant differences in Ang‐2 levels were found between patients with or without IABP. The Ang‐2 levels above the median at day 1 were associated with 30‐day [hazard ratio (HR) 1.98, 95% confidence interval (CI) 1.26–3.10, P = 0.002) and 1‐year mortality (HR 2.21, 95% CI 1.49–3.27, P < 0.001). Stratification of patients according to Ang‐2 levels at day 3 increased these associations (30 days HR 5.15, 95% CI 2.80–9.45, P < 0.001; 1 year HR 5.24, 95% CI 3.19–8.58, P < 0.001). The Ang‐2 concentrations were independent predictors for mortality in multivariate analysis (30 days HR 4.82, 95% CI 1.52–15.23, P = 0.007; 1 year HR 2.01, 95%CI 1.24–3.24, P = 0.005). Predictors of increased Ang‐2 levels at day 3 were baseline Ang‐2, development of acute kidney injury, bleeding events or transfusion, and impaired reperfusion.ConclusionIn CS, high levels of Ang‐2 are independently associated with poor short‐ and long‐term outcome and associated with the reperfusion success as well as complications.Clinical Trial RegistrationURL: www.clinicaltrials.gov; unique identifier: NCT00491036
The long‐term storage of cold‐pressed oil from roasted rapeseed: Effects on antioxidant activity and levels of canolol and tocopherols
Authors: Siger Aleksander , Michalak Michał 
Published: September 2015

The aim of this study was to determine the oxidative stability of rapeseed oils cold pressed from seeds roasted at 140, 160, or 180°C for 5, 10, or 15 min versus the control (oil from unroasted seeds). The oils were stored for a period of 1 year. After 6 and 12 months of storage, the samples were analyzed to determine their peroxide and acid values, the levels of bioactive substances (tocopherols, plastochromanol‐8, and canolol), as well as antioxidant activity (DPPH test). It was shown that roasting the rapeseeds had a significant effect on the oxidative stability of the oils, which increased by almost 50%. In the case of oils pressed from seeds roasted at 140 and 160°C, it was shown that the longer the seeds were roasted, the smaller the reduction in canolol content. After 6 months of storage, the percentage decrease in the canolol content of oils from roasted seeds was recorded to be at a level comparable to that of the control. After 1 year of storage, the percentage loss of canolol was markedly lower (from 18 to 45%) than in the control (61%). The reduction in tocopherol levels was dependent on the duration of storage and on the type of sample. Principal component analysis (PCA) confirmed that the oxidative stability of oils produced from roasted seeds, particularly from those roasted at 180°C, was markedly higher than that of the other samples obtained from roasted seeds and the control.Practical applications: Studies concerning oxidative stability are most typically conducted by applying so‐called accelerated aging tests performed at high temperatures (Rancimat, Oxidograph test). In practice, this undermines the reliability of the results, since it is difficult to draw conclusions about the actual shelf life of a product, on account of the various mechanisms of the oxidation process. At high temperatures, the primary reactions are connected with polymerization and cyclization, which are not comparable to the reactions taking place under normal conditions. The analysis conducted here made it possible to follow the changes during the storage of the oil and the rate of degradation of bioactive substances reflecting cold‐storage conditions.Rapeseed oils cold pressed from seeds subjected to roasting (140–180°C for 5–15 min) were compared to rapeseed oil that was cold pressed from seeds not exposed to elevated temperatures through an analysis of their oxidative stability, antioxidant activity, and levels of bioactive substances (tocopherols, plastochromanol‐8, and canolol). The oils were stored for a period of 12 months at a temperature reflecting cold storage conditions (4°C). It was shown that the oils produced from seeds roasted at 180°C in particular exhibited greater oxidative stability and the best antioxidant properties. Antioxidant activity was shown to correlate with the levels of canolol (r = 0.9927; p < 0.0001) and g‐T (r = 0.9765; p < 0.0001), as well as with total tocopherols (r = 0.9796; p < 0.0001).