bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of liquid CO2 phase change on pores and fractures in coal: An experimental study
Authors: Jiang Zebiao , Gao Shikang , Liu Hao , Chen Siliang , Mo Qiaoshun , He Feng 
Published: July 2024

AbstractThe evolution characteristics of pores and fractures in coal after liquid carbon dioxide (CO2) phase change are important factors that determine the permeability increase effect. Therefore, it is critical to correctly understand the influences of liquid CO2 phase change on pores and fractures in coal. The changes of adsorption and desorption isotherm, pore size, pore volume, and specific surface area of fractured coal and fractured coal were compared by low temperature liquid nitrogen adsorption experiment. In addition, a scanning electron microscope was adopted to observe fracture characteristics of fractured and unfractured coal samples and analyze changes in the connectivity and fracture development. Experimental results show that the fractured coal samples exhibit better hysteresis loops and a larger proportion of gas desorption than the unfractured ones. Fractured coal samples contain more developed pores and fractures compared with unfractured ones, and their fragmentation degree, pore diameter, fracture width, and connectivity of pores and fractures are also better. Besides, the closer the samples from the fracturing boreholes are, the better the fracturing effect. This indicates that liquid CO2 phase change can effectively enhance the gas transport capacity in pores and fractures in coal. The research results provide a solid basis for the better application of liquid CO2 phase‐change fracturing to the prevention of coal and gas outburst disasters and the realization of efficient gas extraction in deep coal seams.
Seasonal differences in participation and time spent in physical activity in Russia: The Know Your Heart survey
Authors: Kaneva Maria , Malyutina Sofia , Moiseenko Victoria , Kudryavtsev Alexander 
Published: July 2024

AbstractThis study aimed to assess the levels and investigate socioeconomic, demographic, and health‐related predictors of winter and summer physical activity (PA) in Russia using the data from the Know Your Heart population survey conducted in Novosibirsk and Arkhangelsk (2015–2018; n = 5068; aged 35–69 years). Employing a series of probit, Tobit, and the Cragg models, we separated the predictors of the probability of participating in leisure‐time PA from the predictors of time spent in PA. Our study showed that financial constraints limited males' participation in winter PA (probability of participation decreased by 12 percentage points) and females' engagement in winter and summer PA (decrease in the number of hours of practicing PA by approximately 1 h a week). Education, self‐reported health, smoking, and cues to action had different impacts on both probability and time spent in PA in winter and summer. We also found significant gender differences in participation and time spent in PA across seasons. Older age, poor health, and smoking were greater obstacles to PA for males compared to females both in winter and summer. However, males were more likely to follow physician's advice to lose weight and take up physical exercise. Information campaigns that promote physical activities, including those that are free of charge, are needed to help limit barriers to PA for people with low socioeconomic status and individuals with little or no exercise experience. Also, making sports more accessible to citizens by providing free and low‐cost sports facilities can increase their participation and time spent in PA, improving individual health and productivity.
Streamflow drought onset and severity explained by non‐linear responses between climate‐catchment and land surface processes
Authors: Raut Aparna , Ganguli Poulomi , Kumar Rohini , Das Bhabani Sankar , Reddy Nagarjuna N. , Wöhling Thomas 
Published: July 2024

AbstractKnowledge of drought onset and its relationship with drought severity (deficit volume) is crucial for providing timely information for reservoir operations, irrigation scheduling, devising cropping choices and patterns and managing surface and groundwater water resources. An analysis of the relationship between drought onset timing and deficit volume can help in drought hazard assessments and associated risks. Despite its importance, little attention has been paid to understand the drought onset timing and its potential linkage with deficit volume for effective drought monitoring and its impact assessment. Further, only a few studies have explored the role of environmental controls, encompassing the interaction between climate, catchment and land‐surface processes in influencing streamflow droughts and associated characteristics such as onset time and severity. This study leverages quality‐controlled streamflow observations from 1965 to 2018 to unveil regional patterns of streamflow drought onset, at‐site trends in deficit volume and detect non‐linear relationships between onset timing and deficit volume across 82 rain‐fed catchments in peninsular India (8°–24° N, 72°–87° E). We show that around 12% of catchments show an earlier onset of streamflow droughts in conjunction with a decreasing trend in deficit volume. Further, approximately one‐third of the catchments show a significant non‐linear dependency between drought deficit volume and onset time. Among catchment controls, such as soil and topographic properties, we found soil organic carbon stock and stock as dominant drivers controlling the streamflow drought onset time. Likewise, sand content and vertical distance to channel network control the streamflow deficit volume. Finally, the linkages between inferred dominant low‐flow generation mechanisms and the specific combinations of environmental controls are synthesized in a conceptual diagram that might assist in developing appropriate models for low‐flow simulations and predictions, especially across ungauged sites. The new insights add value to understanding the chain of physical processes linking climatic and physiographic controls on streamflow droughts, which can support drought forecasting and climate impact assessment efforts.
State of the union: A review of state‐based laws and regulations supporting pharmacist payment for clinical services
Authors:   Advancing Pharmacist Payment Parity Workgroup
Published: July 2024

AbstractIntegrating pharmacists into interdisciplinary care models is essential for achieving the Quintuple Aim in health care, which emphasizes improving patient outcomes, enhancing patient and provider experiences, reducing costs, and advancing health equity. Despite expanded scopes of practice that facilitate collaborative models, pharmacists often face significant barriers due to inconsistent and insufficient reimbursement for their clinical services. This review seeks to address these challenges by focusing on state‐based legislation and regulations that establish payment parity or create pathways for reimbursing pharmacist clinical services. Through a narrative review, this article systematically compares different states' approaches to pharmacist reimbursement by examining affected payers, billable services, and other pertinent details. The ultimate goal is to propose model characteristics for states considering the enhancement or development of legislation and regulations to ensure equitable payment mechanisms for pharmacist services. By providing a comprehensive overview of existing models and identifying effective legislative characteristics, this review aims to inform and empower pharmacists and their advocates with a better understanding of reimbursement regulations and to inspire community‐driven advocacy for equitable compensation, thus supporting the integration of pharmacists as essential health care providers.
CKIP‐1 mediates CK2 translocation to regulate Nav1.5 and Kir2.1 channel complexes in cardiomyocytes
Authors: Li Xinran , Zhao Yingzhu , Xue Mei , Hu Hesheng , Yin Jie , Cheng Wenjuan , Shi Yugen , Wang Ye , Yan Suhua 
Published: July 2024

AbstractSodium and potassium channels, especially Nav1.5 and Kir2.1, play key roles in the formation of action potentials in cardiomyocytes. These channels interact with, and are regulated by, synapse‐associated protein 97 (SAP97). However, the regulatory role of SAP97 in myocyte remains incompletely understood. Here, we investigate the function of SAP97 phosphorylation in the regulation of Nav1.5 and Kir2.1 channel complexes and the upstream regulation of SAP97. We found that SAP97 is phosphorylated by casein kinase II (CK2) in vitro. In addition, transfection of casein kinase 2 interacting protein‐1 (CKIP‐1) into cardiomyocytes to drive CK2 from the nucleus to the cytoplasm, increased SAP97 phosphorylation and Nav1.5 and Kir2.1 current activity. These findings demonstrated that CKIP‐1 modulates the subcellular translocation of CK2, which regulates Nav1.5 and Kir2.1 channel complex formation and activity in cardiomyocytes.
The effects of berberine and curcumin on cardiac, lipid profile and fibrosis markers in cyclophosphamide‐induced cardiac damage: The role of the TRPM2 channel
Authors: Huyut Zübeyir , Yildizhan Kenan , Altındağ Fikret 
Published: July 2024

AbstractCyclophosphamide (CYP) is widely used to treat various types of cancer. In addition to the therapeutic properties of this drug, unfortunately, its side effects are still not fully understood. This study investigated the protective effect of curcumin (CURC) and berberine (BER) on CYP‐induced cardiac damage. Thirty‐six male rats were equally divided into the control, dimethyl sulfoxide (DMSO), CYP, CYP + CURC, CYP + BER and CYP + BER + CURC groups. Troponin‐I, Creatine kinase‐myocardial band (CK‐MB), total cholesterol, triglyceride levels in serum samples, and reactive oxygen species (ROS), poly(ADP‐ribose) polymerase‐1 (PARP‐1), and transient receptor potential melastatin 2 (TRPM2) channel levels in heart tissue were measured using an enzyme‐linked immunoassay (ELISA) kit. In addition, histopathological examination and immunohistochemical investigation of the TRPM2 channel, fibroblast specific protein‐1 (FSP1), transforming growth factor‐beta‐ 1 (TGF‐β1) and α‐smooth muscle actin (α‐SMA) expressions were determined in heart tissue. The CYP group's troponin‐I, total cholesterol, triglyceride, CK‐MB, ROS, PARP‐1 and TRPM2 channel levels were higher than in the other groups in the ELISA measurements (p < 0.05). In contrast, these parameters in the group treated with CURC and BER together with CYP were lower than in the CYP group (p < 0.05). Additionally, CUR and BER reduced CYP‐induced pathological damage, TRPM2, FSP1, TGF‐β1 and α‐SMA expressions. The data showed that CYP administration can cause cardiac damage by increasing the TRPM2 channel, TGF‐β1, FSP1 and α‐SMA expression levels. Therefore, we concluded that CURC and BER administration following CYP application may be used as therapeutic agents to prevent CYP‐induced cardiac damage.
Microwave‐assisted synthesis of 1,4‐disubstituted 1,2,3‐triazole derivatives utilizing NiO/Cu2O nano‐photocatalyst
Authors: Attia Yasser A , Mohamed Yasser MA 
Published: July 2024

AbstractBACKGROUNDThe main characteristic features of nickel–copper‐catalyzed azide–alkyne click (Ni‐CuAAC) reactions for production of 1,2,3‐triazoles are regioselectivity and the reaction proceeding under mild conditions. The use of copper salts as catalysts often leads to challenges like contamination of the prepared triazoles. NiO/Cu2O nanocomposites (NCs) were utilized in Ni‐CuAAC reactions as heterogeneous nanocatalysts to achieve the production of some 1,4‐disubstituted 1,2,3‐triazoles in high chemical yields under microwave irradiation.RESULTSThe preparation of NiO/Cu2O NCs was performed through the coprecipitation of NiO nanoparticles on Cu2O surface. The prepared catalyst was used for catalyzing a reaction between benzoyl azides and phenylacetylene under optimized reaction conditions. The NiO/Cu2O NCs exhibited high catalytic activity compared to Cu2O nanoparticles. In addition, by utilizing ethanol–water as the solvent system under microwave irradiation, higher yields and efficient product separation were observed.CONCLUSIONThis study investigated the proficiency of NiO/Cu2O NCs as effective nanocatalysts for the selective synthesis of some 1,4‐disubstituted 1,2,3‐triazole derivatives. Employing heterogeneous nanoparticle catalysts, such as Cu2O and NiO/Cu2O, offers several advantages over homogeneous catalytic systems. These include easier catalyst separation and recovery, potential for catalyst reuse and the ability to fine‐tune the catalytic properties by modulating the nanoparticle composition and structure. © 2024 Society of Chemical Industry (SCI).
Evaluation of cross‐neutralizing immunity following COVID‐19 primary series vaccination during the Omicron surge in Tanzania
Authors: Nkinda Lilian , Barabona Godfrey , Ngare Isaac , Nkuwi Emmanuel , Kamori Doreen , Msafiri Frank , Kunambi Ponsian P. , Osati Elisha , Kidenya Benson R. , Chuwa Harrison , Kinasa Glory , Hassan Frank E. , Judicate George P. , Gasper Joseph , Kisuse Juma , Mfinanga Sayoki , Senkoro Mbazi , Ueno Takamasa , Lyamuya Eligius , Balandya Emmanuel 
Published: July 2024

AbstractCOVID‐19 vaccine became available in Tanzania during the first wave of the Omicron variant. During that time community seroprevalence of SARS‐CoV‐2 was already at 50%–80%. To date, it remains largely unknown whether ongoing vaccination with the primary series vaccines has any meaningful immune‐boosting effects against newer Omicron subvariants. Therefore, we tested cross‐neutralizing capacity of antibodies elicited by infection, vaccination, or both against SARS‐CoV‐2 Omicron subvariants BA.1, and the newer subvariants BQ.1.1 and XBB.1.5. that were unexperienced by this population. Participants who were either SARS‐CoV‐2 infected‐only (n = 28), infected vaccinated (n = 22), or vaccinated‐only (n = 73) were recruited from Dar‐es‐Salaam, Tanzania, between April and December 2022. Plasma 50% neutralization titers (NT50) against SARS‐CoV‐2 wild‐type strain and Omicron subvariants were quantified by a lentiviral‐based pseudo‐virus assay. Percentage of participants with neutralizing activity against WT and BA.1 was high (>85%) but was reduced against BQ.1.1 (64%–77%) and XBB.1.5 (35%–68%) subvariants. The low median cross‐neutralization titer was slightly higher in the infected vaccinated group compared to vaccine‐only group against BQ.1.1 (NT50 148 vs. 85, p = 0.032) and XBB.1.5 (NT50 85 vs. 37 p = 0.022) subvariants. In contrast, vaccine‐boost among the infected vaccinated did not result to increased cross‐neutralization compared to infected‐only participants (BQ.1.1 [NT50 of 148 vs. 100, p = 0.501] and XBB.1.5 [NT50 86 vs. 45, p = 0.474]). We report severely attenuated neutralization titers against BQ.1.1 and XBB.1.5 subvariants among vaccinated participants, which marginally improved in the infected vaccinated participants. Our findings call for further studies to evaluate effectiveness of the primary series vaccines in preventing severe infection and mortality against the newer variants.
A dimensionally reduction approach to study kink soliton and its fission and fusion process of (3+1)‐dimensional KdV‐CDG equation
Authors: Rahman Mati ur , Sun Mei , Salimi Mehdi , Ahmadian Ali 
Published: July 2024

AbstractThe Hirota bilinear (HB) is a powerful and widely used technique to find various types of solitons of integrable systems. In this manuscript, we implement HB technique to find bilinear form of a dimensionally reduced (3+1)‐dimensional KdV–Calogero–Bogoyavlenskii–Schiff (KdV‐CBS) equation at z = x, z = y, and z = t. We present various results for distinct auxiliary function to study kink solitons and its fission and fusion dynamics. The MATLAB‐2020 is used to display all the results via 3D and line 2D graphs for appropriate values of parameters. These findings provide a strong new insight into the nonlinear features of the model and lay the foundation for future studies in soliton dynamics and nonlinear events in related systems.
Using point‐of‐care ultrasound to determine incidence of deep vein thrombosis after right‐sided radiofrequency catheter ablation
Authors: Qayoom Reema , Asghar Hannah S. , Lutfi Irfan Amjad , Qadir Faisal , Irfan Ghazala , Shafquat Azam 
Published: July 2024

AbstractIntroductionFemoral venous access is routinely used for radiofrequency catheter ablation (RFA) procedures. Deep vein thrombosis (DVT), which is often sub‐clinical, is uncommon following RFCA. Point‐of‐care ultrasound (POCUS) is a cost‐effective way to diagnose DVT. Identification of DVT incidence, especially if sub‐clinical, can direct change in practice to reduce DVT and lay ground for cost‐effective screening strategies postprocedures. The aim of our study is to determine the incidence of DVT after right‐sided radiofrequency cardiac catheter ablation using POCUS.MethodsWe conducted a single‐center prospective cross‐sectional study in patients undergoing right‐sided RFCA. Within 24 h postprocedure, the participants underwent compression venous duplex ultrasonography using POCUS to look for evidence of DVT in cannulated limb. The contralateral limb that was not cannulated was scanned as a control.ResultsA total of 194 patients were scanned post‐right‐sided RFCA procedures. Average age was 43.5 ± 13.2 years and 131 (67.5%) were women. A total of 148 (76.3%) patients underwent AVNRT ablation. Ten (5.2%) patients developed DVT, of which nine had sub‐clinical DVT. Age (>53 years), greater sum of sheaths used (>3) and longer duration of bed rest maintained (up to 4.0 h vs. >4.0 h, p = 0.006) were identified as risk factors.ConclusionMost of the DVTs after right‐sided catheter ablation are sub‐clinical. Routine scanning for DVT after right‐sided catheter ablation as well as reducing number of sheaths and bed rest should be considered.
Dilution of humoral immunity: Results from a natural history study of healthy total knee arthroplasty patients
Authors: Kates Stephen L. , Owen John R. , Beck Christopher A. , Muthukrishnan Gowrishankar , Daiss John L. , Golladay Gregory J. 
Published: July 2024

AbstractThe incidence of prosthetic joint infection (PJI) following elective primary total knee arthroplasty (TKA) is very low but serious risk remains. To identify unknown risk factors, we completed a natural history study of IgG specific for Staphylococcus aureus antigens previously phenotyped as protective (anti‐Atl) and pathogenic (anti‐Isd). Twenty‐five male and 25 female optimized patients 50–85 years of age and BMI 24–39 undergoing primary TKA were prospectively enrolled. Blood sampling was performed preoperatively, postoperative Day 1, and at 2, 6, and 12 weeks, to assess serum cytokine, anti‐staphylococcal IgG levels and anti‐tetanus toxoid IgG measured via custom Luminex assay. Clinical, demographic, and PROMIS‐10 data were collected with outcomes to 2 years postop. All participants completed the study and 2‐year follow‐up. No patients were readmitted or noted to develop a surgical site infection or serious adverse event, and patient‐reported outcomes were improved. Serology revealed a highly significant decrease in six out of eight antibody titers against specific S. aureus antigens on Day 1 (p < 0.0001), five of which normalized to preoperative levels within 2 weeks. These changes were commensurate with a decrease and recovery of anti‐tetanus toxoid titers, and a 20% drop in hemoglobin 13.8 ± 1.7 at preop to 11.1 ± 1.8 mg/dL on Day 1 (p < 0.0001). After TKA, a significant decrease in humoral immunity commensurate with blood loss and hemodilution was recorded. This decrease in circulating anti‐staphylococcal antibodies in the early postop period may represent a periprosthetic joint infection risk factor for patients.
Effects of different pretreatment methods on the degree of substitution, structure, and physicochemical properties of synthesized malic acid sweet potato starch ester
Authors: Wang Wei , Liu Shiwei , Li Yu , Yan Jiatian , Hu Aijun , Zheng Jie 
Published: July 2024

AbstractBACKGROUNDThe preparation of malic acid starch ester (MSE) is mostly carried out using a high temperature method, but there are problems such as high energy consumption, long preparation time, and uneven heating. Microwave technology can be used to overcome these limitations. The semi‐crystalline structure of starch granules hinders the modifier's access to the matrix, thus limiting the esterification reaction. Physical techniques can act on the interior of the starch to create a number of active sites, thereby facilitating the reaction of the starch with esterification reagents. Therefore, this study investigated the effect of starch pretreatment by microwave, heat‐moisture, and ultrasonic techniques on the degree of substitution (DS), structure, and physicochemical properties of MSE synthesized by the microwave method.RESULTSThe DS of MSE was increased after pretreatments. The modified starch obtained by different pretreatment methods did not show new characteristic peaks, while the MSE synthesized showed new absorption peaks near 1735 cm−1. The granular structure and morphology of the modified starch obtained by microwave and heat‐moisture pretreatment were gelatinized and aggregated, while some of the starch particles of the modified starch obtained by ultrasonic pretreatment appeared pore‐sized. The relative crystallinity and gelatinization enthalpy of the MSE were reduced, but the crystallization pattern remained as A‐type.CONCLUSIONOverall, the results suggest that various pretreatment methods can enhance the DS of MSE by disrupting the structure of starch. The findings of this study provide theoretical support for improving the DS of esterified starch. © 2024 Society of Chemical Industry.
Pre‐harvest application of sodium nitroprusside enhances storage root quality in red beet cultivated under normal and drought conditions
Authors: Ferreira Lucélio Mendes , Henschel Juliane Maciel , Mendes Janaine Juliana Vieira de Almeida , Araujo Damiana Justino , Ribeiro José Evangelista Santos , Ferreira Valquiria Cardoso da Silva , da Cruz Oziel Nunes , Batista Diego Silva 
Published: July 2024

AbstractBACKGROUNDThe role of nitric oxide (NO) in plant stress tolerance, as well as in increasing post‐harvest quality, has been extensively demonstrated in several fruits and vegetable crops; however, the effects of its pre‐harvest application on post‐harvest quality are still poorly documented. Therefore, the pre‐harvest application of NO in red beet (Beta vulgaris subsp. vulgaris) plants cultivated under well‐watered and drought conditions was evaluated to assess whether it improves the post‐harvest quality of their storage roots. Red beet plants cultivated under well‐watered (80% of water holding capacity) or drought condition (15% of water holding capacity) were sprayed weekly with water (control) or 100 μmol L−1 sodium nitroprusside (SNP), an NO donor. Sixty‐six days after sowing, red beet roots were harvested, and root yield, total sugar yield, reducing sugars, non‐reducing sugars, proteins, lipids, root ashes, root moisture, soluble solids, titratable acidity, pH, vitamin C, total phenolics, total betalains, betacyanins, betaxanthins and antioxidant capacity were determined.RESULTSWhile drought led to a reduction in root yield, sugars, lipids and titratable acidity, it increased phenolic compounds, betalains and the antioxidant capacity of beets. SNP reversed the negative effects of drought on sugar, lipid and organic acid contents and increased antioxidant capacity independent of stress.CONCLUSIONPre‐harvest SNP treatment reversed drought‐induced yield reductions in beets, while boosting bioactive compounds and antioxidant capacity. It also enhanced vitamin C content independently, indicating its dual role in stress mitigation and beet quality improvement. Future research should explore other crops and stress conditions. © 2024 Society of Chemical Industry.