bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Mandibular Ridge Oral Mucosa Model of Stromal Influences on the Endothelial Tip Cells: An Immunohistochemical and TEM Study
Authors: Rusu Mugurel Constantin , Didilescu Andreea Cristiana , Stănescu Ruxandra , Pop Florinel , Mănoiu Valentina Mariana , Jianu Adelina Maria , Vâlcu Marek 
Published: November 2012

AbstractThis study aimed to evaluate by immunohistochemistry and transmission electron microscopy (TEM) the morphological features of the oral mucosa endothelial tip cells (ETCs) and to determine the immune and ultrastructural patterns of the stromal nonimmune cells which could influence healing processes. Immune labeling was performed on bioptic samples obtained from six edentulous patients undergoing surgery for dental implants placement; three normal samples were collected from patients prior to the extraction of the third mandibular molar. The antibodies were tested for CD34, CD117(c‐kit), platelet derived growth factor receptor‐alpha (PDGFR‐α), Mast Cell Tryptase, CD44, vimentin, CD45, CD105, alpha‐smooth muscle actin, FGF2, Ki67. In light microscopy, while stromal cells (StrCs) of the reparatory and normal oral mucosa, with a fibroblastic appearance, were found positive for a CD34/CD44/CD45/CD105/PDGFR‐α/vimentin immune phenotype, the CD117/c‐kit labeling led to a positive stromal reaction only in the reparatory mucosa. In TEM, non‐immune StrCs presenting particular ultrastructural features were identified as circulating fibrocytes (CFCs). Within the lamina propria CFCs were in close contact with ETCs. Long processes of the ETCs were moniliform, and hook‐like collaterals were arising from the dilated segments, suggestive for a different stage migration. Maintenance and healing of oral mucosa are so supported by extensive processes of angiogenesis, guided by ETCs that, in turn, are influenced by the CFCs that populate the stromal compartment both in normal and reparatory states. Therefore, CFCs could be targeted by specific therapies, with pro‐ or anti‐angiogenic purposes. Anat Rec, 2013. © 2012 Wiley Periodicals, Inc.
Fructose 1,6‐Bisphosphate Trisodium Salt as A New Phosphorus Source for the Rapid Microwave Synthesis of Porous Calcium–Phosphate Microspheres and their Application in Drug Delivery
Authors: Qi Chao , Zhu Ying‐Jie , Chen Feng 
Published: November 2012

AbstractCalcium phosphates (CPs), as the major inorganic component of biological hard tissues, have been investigated for applications as biomaterials owing to their excellent biocompatibility. However, the traditional synthetic CPs are usually prepared from inorganic phosphorus and calcium sources. Herein, we report a new strategy for the synthesis of a variety of calcium–phosphate nanostructures, including porous amorphous calcium phosphate (ACP) microspheres, hydroxyapatite (HAP) nanorods, and ACP/HAP composite microspheres, by using fructose 1,6‐bisphosphate trisodium salt (FBP) as an organic phosphorus source in aqueous solution in a rapid microwave‐assisted hydrothermal reaction. The important role of FBP and the effect of the experimental conditions on the formation and evolution of the CPs nanostructures were investigated. The crystal phase and composition of the as‐prepared products were characterized by powder X‐ray diffraction (XRD), FTIR spectroscopy, and thermogravimetric (TGA) analysis and the morphologies of the products were characterized by SEM and TEM. This method is facile, rapid, surfactant‐free, and environmentally friendly. The as‐prepared porous ACP microspheres have a relatively high drug‐loading capacity and good sustained drug‐release behavior; thus, they are promising for applications in drug delivery.
Tissue scaffold surface patterning for clinical applications
Authors: Gerberich Brandon G. , Bhatia Sujata K. 
Published: November 2012

AbstractPatterned scaffold surfaces provide a platform for highly defined cellular interactions, and have recently taken precedence in tissue engineering. Despite advances in patterning techniques and improved tissue growth, no clinical studies have been conducted for implantation of patterned biomaterials. Four major clinical application fields where patterned materials hold great promise are antimicrobial surfaces, cardiac constructs, neurite outgrowth, and stem cell differentiation. Specific examples include applications of patterned materials to (i) counter infection by antibiotic resistant bacteria, (ii) establish proper alignment and contractile force of regrown cardiac cells for repairing tissue damaged by cardiac infarction, (iii) increase neurite outgrowth for central nervous system wound repair, and (iv) host differentiated stem cells while preventing reversion to a pluripotent state. Moreover, patterned materials offer unique advantages for artificial implants which other constructs cannot. For example, by inducing selective cell adhesion using topographical cues, patterned surfaces present cellular orientation signals that lead to functional tissue architectures. Mechanical stimuli such as modulus, tension, and material roughness are known to influence tissue growth, as are chemical stimuli for cell adhesion. Scaffold surface patterns allow for control of these mechanical and chemical factors. This review identifies research advances in scaffold surface patterning, in light of pressing clinical needs requiring organization of cellular interactions.
Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor
Authors: Boado Ruben J. , Lu Jeff Zhiqiang , Hui Eric K.‐W. , Sumbria Rachita K. , Pardridge William M. 
Published: November 2012

AbstractMetachromatic leukodystrophy (MLD) is a lysosomal storage disorder of the brain caused by mutations in the gene encoding the lysosomal sulfatase, arylsulfatase A (ASA). It is not possible to treat the brain in MLD with recombinant ASA, because the enzyme does not cross the blood‐brain barrier (BBB). In the present investigation, a BBB‐penetrating IgG‐ASA fusion protein is engineered and expressed, where the ASA monomer is fused to the carboxyl terminus of each heavy chain of an engineered monoclonal antibody (MAb) against the human insulin receptor (HIR). The HIRMAb crosses the BBB via receptor‐mediated transport on the endogenous BBB insulin receptor, and acts as a molecular Trojan horse to ferry the ASA into brain from blood. The HIRMAb‐ASA is expressed in stably transfected Chinese hamster ovary cells grown in serum free medium, and purified by protein A affinity chromatography. The fusion protein retains high affinity binding to the HIR, EC50 = 0.34 ± 0.11 nM, and retains high ASA enzyme activity, 20 ± 1 units/mg. The HIRMAb‐ASA fusion protein is endocytosed and triaged to the lysosomal compartment in MLD fibroblasts. The fusion protein was radio‐labeled with the Bolton–Hunter reagent, and the [125I]‐HIRMAb‐ASA rapidly penetrates the brain in the Rhesus monkey following intravenous administration. Film and emulsion autoradiography of primate brain shows global distribution of the fusion protein throughout the monkey brain. These studies describe a new biological entity that is designed to treat the brain of humans with MLD following non‐invasive, intravenous infusion of an IgG‐ASA fusion protein. Biotechnol. Bioeng. 2013; 110: 1456–1465. © 2012 Wiley Periodicals, Inc.
Combined effects of direct current stimulation and immobilized BMP‐2 for enhancement of osteogenesis
Authors: Zhang Jieyu , Neoh Koon Gee , Hu Xuefeng , Kang En‐Tang , Wang Wilson 
Published: November 2012

AbstractDirect current (DC) stimulation has been used to promote bone repair and osteogenesis, but problems associated with the implanted metal electrodes may limit its application and compromise the therapeutic results. The replacement of the metal electrodes with a biodegradable conductive polymer film can potentially overcome these problems. In our work, polypyrrole/chitosan films comprising polypyrrole nanoparticles dispersed in a chitosan matrix were prepared. The polypyrrole/chitosan film meets the requirements for DC delivery, as indicated by its electrical conductivity, biodegradability, and mechanical properties. The film supports osteoblast growth to the same degree as dentine discs (a bone‐like mineralized substrate), confirming that it is non‐cytotoxic. Our results showed that optimal DC stimulation was achieved with 200 µA for 4 h per day, and under this condition, osteoblast metabolic activity on Day 7 increased by 1.8‐fold over that without DC stimulation. To further improve osteogenesis on the polypyrrole/chitosan film, bone morphogenetic protein‐2 (BMP‐2) was covalently immobilized on the film surface. Osteoblasts cultured on the BMP‐2‐functionalized polypyrrole/chitosan film and subjected to the optimal DC stimulation exhibited a significant increase in cellular metabolic activity (2.3‐fold on Day 7), ALP activity (1.7‐fold on Day 21) and mineralization (twofold on Day 21) over those cultured on polypyrrole/chitosan film without DC stimulation. Osteogenic gene expression results showed that BMP‐2 and DC stimulation by itself enhanced osteoblast differentiation, and a combination of these two factors resulted in synergistic effects on osteoblast differentiation and maturation. Biotechnol. Bioeng. 2013; 110: 1466–1475. © 2012 Wiley Periodicals, Inc.
Fading Majority Cultures: The Implications of Transnationalism and Demographic Changes for Immigrant Acculturation
Authors: van Oudenhoven Jan Pieter , Ward Colleen 
Published: November 2012

ABSTRACTProcesses of globalisation, migration, and increasing cultural diversity within nations have resulted in a growing need to understand intercultural relations in plural societies. Accordingly, this paper highlights the relations between immigrants and members of host societies and considers how social and demographic changes may affect acculturation and intercultural relations and shape future psychological theory and research in these areas. Based on a combination of empirical data and informed speculation, we discuss three significant changes. First is the growing importance of transnational relations due to a large degree of faster and cheaper forms of communication and traveling. A second important factor is changing demographics characterised by the growth of mega‐cities and the increasing proportion of first and second generation of immigrants in contemporary immigration nations and – consequently – the diminishing size of native majority groups. Third is the greater acceptance of a global culture, which is shaped by globalisation and coloured by local multi‐ethnic characteristics and creolisation processes in each country of settlement. Copyright © 2012 John Wiley & Sons, Ltd.
Asymmetric ZnO Panel‐Like Hierarchical Architectures with Highly Interconnected Pathways for Free‐Electron Transport and Photovoltaic Improvements
Authors: Shi Yantao , Zhu Chao , Wang Lin , Li Wei , Fung Kwok Kwong , Wang Ning 
Published: November 2012

AbstractThrough a rapid and template‐free precipitation approach, we synthesized an asymmetric panel‐like ZnO hierarchical architecture (PHA) for photoanodes of dye‐sensitized solar cells (DSCs). The two sides of the PHA are constructed differently using densely interconnected, mono‐crystalline and ultrathin ZnO nanosheets. By mixing these PHAs with ZnO nanoparticles (NPs), we developed an effective and feasible strategy to improve the electrical transport and photovoltaic performance of the composite photoanodes of DSCs. The highly crystallized and interconnected ZnO nanosheets largely minimized the total grain boundaries within the composite photoanodes and thus served as direct pathways for the transport and effective collection of free electrons. Through low‐temperature (200 °C) annealing, these novel composite photoanodes achieved high conversion efficiencies of up to 5.59 % for ZnO‐based quasi‐solid DSCs.
Improvement of TiO2/Dye/Electrolyte Interface Conditions by Positional Change of Alkyl Chains in Modified Panchromatic Ru Complex Dyes
Authors: Kimura Mutsumi , Masuo Junya , Tohata Yuki , Obuchi Kazumichi , Masaki Naruhiko , Murakami Takurou N. , Koumura Nagatoshi , Hara Kojiro , Fukui Atsushi , Yamanaka Ryohsuke , Mori Shogo 
Published: November 2012

AbstractA series of panchromatic ruthenium sensitizers (MJ sensitizers) with attached thiophene and phenyl units bearing alkyl chains was synthesized. A new synthetic route was used to examine all possible positions for the alkyl chains. The absorption spectra showed the sum of a ruthenium complex and peripheral organic chromophore units. The hypochromic effect and blueshift of the metal‐to‐ligand charge‐transfer band observed in the modified ruthenium sensitizers were suppressed by changing the positions of the alkyl chains on the attached thiophene ring. Changing only one alkyl chain also influenced the performance of dye‐sensitized solar cells. Ruthenium sensitizer MJ‐10 with bulky substituent harvests visible and near‐infrared light, and solar cells sensitized by MJ‐10 exhibit an efficiency of 9.1 % under 1 sun irradiation.
ChemInform Abstract: Unique Seven‐Node Rare‐Earth Octacyanomolybdate(IV) Three‐Dimensional Molecular Frameworks: {[Er(H2O)5(Er (H2O)4)3] [Mo(CN)8]3·11H2O}n and {[Eu(H2O)5(Eu (H2O)4)3] [Mo(CN)8]3·11H2O}n.
Authors: Semenyshyn Dariya , Typilo Iryna , Sereda Olha , Dolomanov Oleg , Stoeckli‐Evans Helen 
Published: November 2012

AbstractGood quality single crystals of the title compound are obtained by reaction of H4[Mo(CN)8] with the rare earth carbonates.
ChemInform Abstract: Gd4Ge3‐xPnx (Pn: P, Sb, Bi, x = 0.5—3): Stabilizing the Nonexisting Gd4Ge3 Binary Through Valence Electron Concentration. Electronic and Magnetic Properties of Gd4Ge3‐xPnx.
Authors: Cheung Yan Yin Janice , Svitlyk Volodymyr , Mozharivskyj Yurij 
Published: November 2012

AbstractThe title compounds are prepared by arc melting of the elements and characterized by powder and single crystal XRD, magnetic measurements, and TB‐LMTO electronic band structure calculations.
ChemInform Abstract: Fragmentation of the Fluorite Type in Fe8Al17.4Si7.6: Structural Complexity in Intermetallics Dictated by the 18 Electron Rule.
Authors: Fredrickson Rie T. , Fredrickson Daniel C. 
Published: November 2012

AbstractThe title compound is prepared from mixtures of the elements (600 °C, 24—700 h) and characterized by single crystal XRD, wavelength‐dispersive X‐ray spectroscopy, and DFT electronic structure calculations.
ChemInform Abstract: High Pressure Synthesis and Superconductivity of the Ternary Compounds Mg(Mg1‐xAlx)Si with the Anticotunnite Structure.
Authors: Ji Shidong , Tanaka Masashi , Zhang Shuai , Yamanaka Shoji 
Published: November 2012

AbstractTitle compounds with 0.3 < x < 0.8 are prepared by high‐temperature/high‐pressure reaction of the elements (h‐BN cell, 5 GPa, 800—1100 °C).
ChemInform Abstract: Mixed Valence Tungsten (IV,V) Compounds with Layered Structures. Part 4. Syntheses, Crystal Structures, and Conductivity of BiX2[W2O2X6] (X: Cl, Br).
Authors: Schieweling Marcel , Daniels Joerg , Beck Johannes 
Published: November 2012

AbstractBiCl2[W2O2Cl6] is prepared by reaction of metallic Bi and WOCl4 (sealed silica tube, 650 K, 7 d; 80% yield) and BiBr2[W2O2Br6] is obtained from Bi and WOBr4 (670 K, 50 d; 20% yield).
ChemInform Abstract: Regioselective Addition of Cyclic Nitrones to Feist′s Acid Dimethyl Ester.
Authors: Molchanov A. P. , Tran T. Q. , Kostikov R. R. 
Published: November 2012

AbstractCyclic nitrones regioselectively add to Feist′s acid dimethyl ester (II) yielding diastereoisomeric mixtures of isoxazolidines which are susceptible to thermal rearrangement reactions.
ChemInform Abstract: Ordered Mesoporous Proline Organocatalyst with High Activity and Strong Durability in Promoting Intermolecular Cross‐Conjugated Additions.
Authors: He Wenhan , Zhang Fang , Shi Xiaodong , Li Hexing 
Published: November 2012

AbstractA new proline based catalyst (PRORG) is successfully applied to the presented reaction and gives similar results to proline.
ChemInform Abstract: Triflimide‐Catalyzed Allyl—Allyl Cross‐Coupling: A Metal‐Free Allylic Alkylation.
Authors: Ding Feiqing , William Ronny , Wang Fei , Liu Xue‐Wei 
Published: November 2012

AbstractA new simple and mild protocol for excellent regioselective direct catalytic allylic alkylation of acetates is presented by using a simple, cheap, and easily accessible catalyst.
ChemInform Abstract: Activation of H2O2 by Chiral Confined Broensted Acids: A Highly Enantioselective Catalytic Sulfoxidation.
Authors: Liao Saihu , Coric Ilija , Wang Qinggang , List Benjamin 
Published: November 2012

AbstractA diversity of sulfides is efficiently oxidized to enantioenriched sulfoxides with hydrogen peroxide in the presence of chiral Broensted acid (DPA).
ChemInform Abstract: Sodium Sulfinate‐Mediated trans‐Stilbene Formation from Benzylic Halides.
Authors: Zhao Feng , Luo Jiaying , Tan Qi , Liao Yunfeng , Peng Shengming , Deng Guo‐Jun 
Published: November 2012

AbstractUnder optimized transition metal free conditions, benzylic chlorides and bromides are transformed to the stilbenes under air.
ChemInform Abstract: Phosphine‐Catalyzed Asymmetric [4 + 1] Annulation of Morita—Baylis—Hillman Carbonates with Dicyano‐2‐methylenebut‐3‐enoates.
Authors: Zhang Xiao‐nan , Deng Hong‐Ping , Huang Long , Wei Yin , Shi Min 
Published: November 2012

AbstractThe novel title reaction provides an efficient and enantioselective synthesis of highly functionalized cyclopentenes.
ChemInform Abstract: Copper(I)‐Catalyzed Cascade Dearomatization of 2‐Substituted Tryptophols with Arylidonium Salts.
Authors: Liu Chuan , Zhang Wei , Dai Li‐Xin , You Shu‐Li 
Published: November 2012

AbstractFuro‐fused indolines bearing two quaternary carbon centers are formed by the title reaction using diaryl‐ or vinyl(phenyl)iodonium triflates and an optimized copper catalyst.
ChemInform Abstract: One‐Pot, Two‐Step Conversion of Aldehydes to Phosphonyl‐ and Sulfonylpyrazoles Using Bestmann—Ohira Reagent.
Authors: Kumar Rahul , Verma Deepti , Mobin Shaikh M. , Namboothiri Irishi N. N. 
Published: November 2012

AbstractThe Bestmann—Ohira reagent (Ia) is employed traditionally as a Horner—Wadsworth—Emmons reagent in the conversion of aldehydes to the terminal acetylene intermediates (III).
ChemInform Abstract: In vitro and in vivo Biological Evaluation of New 4,5‐Disubstituted 1,2,3‐Triazoles as cis‐Constrained Analogues of Combretastatin A4.
Authors: Blanch Nuria Mur , Chabot Guy G. , Quentin Lionel , Scherman Daniel , Bourg Stephane , Dauzonne Daniel 
Published: November 2012

AbstractTriazoles (IV) and (VI) are obtained according to procedures already described or reported.
ChemInform Abstract: Polypharmacology of Sulfonamides: Pazopanib, a Multitargeted Receptor Tyrosine Kinase Inhibitor in Clinical Use, Potently Inhibits Several Mammalian Carbonic Anhydrases.
Authors: Winum Jean‐Yves , Maresca Alfonso , Carta Fabrizio , Scozzafava Andrea , Supuran Claudiu T. 
Published: November 2012

AbstractTitle compound (I) and related sulfonamides are low nanomolar inhibitors of many of the 15 human carbonic anhydrase isoforms hCA I‐XV.
ChemInform Abstract: Novel Three‐Component Reaction of Perimidines with 1,3,5‐Triazines and Carbonyl Compounds in Polyphosphoric Acid. An Efficient Method for peri‐Anellation of a Carbocyclic and Pyridine Ring.
Authors: Aksenov A. V. , Aksenov N. A. , Lyakhovnenko A. S. , Kumshaeva A. B. , Aksenova I. V. 
Published: November 2012

Abstract1,3‐Diazapyrenes (IV) and (VI), tetrahydro‐1,3‐diazapyrenes (VIII) and 1,3,7‐triazapyrenes (IX) are synthesized by three‐component reactions of perimidines (I).
ChemInform Abstract: Facile Synthesis, Cytotoxic and Antimicrobial Activity Studies of a New Group of 6‐Aryl‐3‐[4‐(methylsulfonyl)benzyl]‐7H‐[1,2,4]triazolo[3,4‐b] [1,3,4]thiadiazines.
Authors: Sumangala V. , Poojary Boja , Chidananda N. , Arulmoli T. , Shenoy Shalini 
Published: November 2012

AbstractAcid hydrazide (I) reacts with carbon disulfide (II) affording potassium dithiocarbazinate, which upon treatment with hydrazine hydrate undergoes ring closure.
ChemInform Abstract: Highly Regioselective Synthesis of N‐3 Organophosphorous Derivatives of 3,4‐Dihydropyrimidin‐2(1H)‐ones and Their Calcium Channel Binding Studies.
Authors: Singh Kamaljit , Singh Kawaljit , Trappanese Danielle M. , Moreland Robert S. 
Published: November 2012

AbstractA series of novel dihydropyrimidine derivatives bearing diaminophosphinyl (III), phosphonate moieties (Vc) or phosphacycles (VII) at N‐3 are prepared by regioselective reactions between phosphoryl dichlorides (II) and various nucleophiles.
ChemInform Abstract: Unusual Control of Reaction Selectivity Through a Subtle Change in the Ligand: Proof of Concept and Application in Pd‐Catalyzed C—P Bond Formation.
Authors: Ananikov Valentine P. , Ivanova Julia V. , Khemchyan Levon L. , Beletskaya Irina P. 
Published: November 2012

AbstractA new catalytic system is presented with the ability to control reaction selectivity.
ChemInform Abstract: Reaction of 3‐Phenyl‐1,2,4‐triazin‐5(4H)‐one under Acylating Conditions with Natural Alcohols Containing an Asymmetric Carbon Atom.
Authors: Egorov I. N. , Zyryanov G. V. , Slepukhin P. A. , Tseitler T. A. , Rusinov V. L. , Chupakhin O. N. 
Published: November 2012

AbstractNucleophilic addition reactions of natural chiral alcohols such as optically pure borneol or cholesterol to triazinone (II) in the presence of carboxylic acid anhydrides occur nondiastereoselectively, independent of the medium used.
ChemInform Abstract: Synthesis and Biological Activity Evaluation of Cytidine‐5′‐deoxy‐5‐fluoro‐N‐[(alkoxy/aryloxy)] Carbonyl‐Cyclic 2′,3′‐Carbonates.
Authors: Rani V. Jhansi , Raghavendra A. , Kishore P. , Kumar Y. Nanda , Kumar K. Hema , Jagadeeswarareddy K. 
Published: November 2012

AbstractA small series of 5′‐deoxy‐5‐fluorocytidine derivatives (I) is synthesized to enhance the efficacy of capacitabine, an oral prodrug of 5‐FU.
ChemInform Abstract: Transparent Thin Films of Bi2WO6, Bi4Ti3O12 and Sr0.75Ba0.25Nb2O6.
Authors: Wollmann P. , Schumm B. , Kaskel S. 
Published: November 2012

AbstractTransparent thin films of the title compounds are prepared by a sol—gel method using Bi(NO3)3 and WO3 or (NH4)2TiO(C2O4)2, or Sr(OAc)2, Ba(OAc)2, and NH4NbO(C2O4)2 as starting materials and diethylenetriaminepentaacetic acid or EDTA as complexing agent.
ChemInform Abstract: Noble Metals in Polyoxometalates
Authors: Izarova Natalya V. , Pope Michael T. , Kortz Ulrich 
Published: November 2012

AbstractReview: polyoxovanadates, ‐molybdates, ‐tungstates, ‐palladates, ‐platinates, and ‐aurates; 159 refs.
ChemInform Abstract: The Principles and Evolution of Magnetic Resonance Imaging
Authors: Lakrimi M. , Thomas A. M. , Hutton G. , Kruip M. , Slade R. , Davis P. , Johnstone A. J. , Longfield M. J. , Blakes H. , Calvert S. , et al. et al. 
Published: November 2012

AbstractReview: 22 refs.