bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indication for surgical treatment in patients with adolescent idiopathic scoliosis – a critical appraisal and counter-point
Authors: Bachmann Keith R , Goodwin Ryan C , Moore Timothy A 
Published: July 2013

AbstractIn a recent letter to the editor (Patient Saf. Surg. 2013, 7:17), Weiss and Moramarco made the claim that surgical correction of idiopathic scoliosis is not supported based on the available literature citing no medical indication and high complication rates as compared to non-operative management. In this letter we show that there is a role for surgical treatment as the only predictable option to obtain correction of a curve and that the risk of complications with newer instrumentation does not approach 50% as cited by Weiss and Moramarco. We share the opinion with Weiss and Moramarco that a decision for surgery is not one to be made lightly, and should include options of purely observation, bracing, as well as surgery depending on the potential progression profile and conversations with the child and parents.
An inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue
Authors: O’Connor Amber K , Malarkey Erik B , Berbari Nicolas F , Croyle Mandy J , Haycraft Courtney J , Bell P Darwin , Hohenstein Peter , Kesterson Robert A , Yoder Bradley K 
Published: July 2013

AbstractBackgroundCilia are found on nearly every cell type in the mammalian body, and have been historically classified as either motile or immotile. Motile cilia are important for fluid and cellular movement; however, the roles of non-motile or primary cilia in most tissues remain unknown. Several genetic syndromes, called the ciliopathies, are associated with defects in cilia structure or function and have a wide range of clinical presentations. Much of what we know about the formation and maintenance of cilia comes from model systems likeC. elegansandChalmydomonas. Studies of mammalian cilia in live tissues have been hampered by difficulty visualizing them.ResultsTo facilitate analyses of mammalian cilia function we generated an inducible CiliaGFPmouse by targeting mouse cDNA encoding a cilia-localized protein somatostatin receptor 3 fused to GFP (Sstr3::GFP) into the ROSA26 locus. In this system, Sstr3::GFP is expressed from the ubiquitous ROSA26 promoter after Cre mediated deletion of an upstream Neo cassette flanked by lox P sites. Fluorescent cilia labeling was observed in a variety of live tissues and after fixation. Both cell-type specific and temporally regulated cilia labeling were obtained using multiple Cre lines. The analysis of renal cilia in anesthetized live mice demonstrates that cilia commonly lay nearly parallel to the apical surface of the tubule. In contrast, in more deeply anesthetized mice the cilia display a synchronized, repetitive oscillation that ceases upon death, suggesting a relationship to heart beat, blood pressure or glomerular filtration.ConclusionsThe ability to visualize cilia in live samples within the CiliaGFPmouse will greatly aid studies of ciliary function. This mouse will be useful forin vivogenetic and pharmacological screens to assess pathways regulating cilia motility, signaling, assembly, trafficking, resorption and length control and to study cilia regulated physiology in relation to ciliopathy phenotypes.
Erratum: Simplified Analytical Pushover Method for Precast Segmental Concrete Bridge Columns (Vol. 16, 805–822, 2013)
Authors: Bu Zhan-Yu , Ou Yu-Chen 
Published: July 2013

In page 807 paragraph 1 line 7, there was an error with the figure name, the correct version appears below: column enters the second stage [Figure 1(b)]. In page 812, there was an error with equation 25. The correct version appears below: [Formula: see text]
First report of fingerprinting dried herbal products using a subtractive diversity array
Authors: Niu Linhai , Mantri Nitin , Wohlmuth Hans , Li Chunguang , Xue Charlie C. , Pang Edwin 
Published: July 2013

Abstract
Introduction Sequence-independent microarrays have never been used to identify and authenticate dried herbal plants. Methods: We report successful fingerprinting of seven species: Leonurus sibiricus, Astragalus membranaceus, Coix lachryma-jobi, Magnolia biondii, Abutilon theophrasti, Physalis alkekengi, and Salvia miltiorrhiza from dried tissues using a sequence-independent microarray, “Subtracted Diversity Array”.

Results: Herbal plants could be identified from tissues as they were sold at the clinic. Hierarchical cluster of these species generated using SPSS v.15.0 confirmed to their predicted taxonomical relationships as specified in the Angiosperm Phylogeny Group II classification system. A polymorphism rate of 40.7% was achieved from the 376 spots used for fingerprinting. Functional characterization of polymorphic features by sequencing revealed 27.1% of those were retroelements or genes.

Conclusions: This technique provides a new way to produce markers for authenticating dried herbal samples.
Research utilization and evidence-based practice among Saskatchewan massage therapists
Authors: Gowan-Moody Donelda M. , Leis Anne M. , Abonyi Sylvia , Epstein Michael , Premkumar Kalyani 
Published: July 2013

Abstract
While massage therapy (MT) is an increasingly used health care service with a growing evidence base, there is insufficient information about the extent to which MT practice is evidence-based. The purpose of this study was to provide a comprehensive view of Saskatchewan MT’s research utilization to inform the development of evidence-based massage therapy practice. The main objectives of the study were to describe MT’s perceptions of research, their appraised self-efficacy in research literacy and to identify the characteristic of practitioners who use research. Using a survey design all 815 registered members of the Massage Therapist Association of Saskatchewan were invited to complete a mail-out questionnaire. A total of 333 questionnaires were completed and returned for a 41% response rate. Univariate and logistic regression analysis was conducted using SPSS 17.0. While overall perceptions of research were positive, self-efficacy in research literacy was low and research utilization was limited. Characteristics associated with research use included referring to online research databases and peer-reviewed journals, belief that practice should be based on research, and 20 or greater hours per week of practice. Provincial regulatory status may be the first step to quality service delivery and research literacy training and support is needed for practitioners.
Robert Heath Lock and His Textbook of Genetics, 1906
Authors: Edwards A W F 
Published: July 2013

AbstractRobert Heath Lock (1879–1915), a Cambridge botanist associated with William Bateson and R. C. Punnett, published his book Recent Progress in the Study of Variation, Heredity, and Evolution in 1906. This was a remarkable textbook of genetics for one appearing so early in the Mendelian era. It covered not only Mendelism but evolution, natural selection, biometry, mutation, and cytology. It ran to five editions but was, despite its success, largely forgotten following Lock’s early death in 1915. Nevertheless it was the book that inspired H. J. Muller to do genetics and was remembered by A. H. Sturtevant as the source of the earliest suggestion that linkage might be related to the exchange of parts between homologous chromosomes. Here we also put forward evidence that it had a major influence on the statistician and geneticist R. A. Fisher at the time he was a mathematics student at Cambridge.
Robust Identification of Local Adaptation from Allele Frequencies
Authors: Günther Torsten , Coop Graham 
Published: July 2013

Abstract
Comparing allele frequencies among populations that differ in environment has long been a tool for detecting loci involved in local adaptation. However, such analyses are complicated by an imperfect knowledge of population allele frequencies and neutral correlations of allele frequencies among populations due to shared population history and gene flow. Here we develop a set of methods to robustly test for unusual allele frequency patterns and correlations between environmental variables and allele frequencies while accounting for these complications based on a Bayesian model previously implemented in the software Bayenv. Using this model, we calculate a set of “standardized allele frequencies” that allows investigators to apply tests of their choice to multiple populations while accounting for sampling and covariance due to population history. We illustrate this first by showing that these standardized frequencies can be used to detect nonparametric correlations with environmental variables; these correlations are also less prone to spurious results due to outlier populations. We then demonstrate how these standardized allele frequencies can be used to construct a test to detect SNPs that deviate strongly from neutral population structure. This test is conceptually related to FST and is shown to be more powerful, as we account for population history. We also extend the model to next-generation sequencing of population pools—a cost-efficient way to estimate population allele frequencies, but one that introduces an additional level of sampling noise. The utility of these methods is demonstrated in simulations and by reanalyzing human SNP data from the Human Genome Diversity Panel populations and pooled next-generation sequencing data from Atlantic herring. An implementation of our method is available from http://gcbias.org.
Semiconductor Nanostructures defined by self-organizing Polymers
Authors: Haupt Michael , Miller Stephan , Ladenburger Andreas , Sauer Rolf , Thonke Klaus , Riethmueller Silke , Moeller Martin , Banhart Florian 
Published: July 2013

AbstractIn the near future it will be more and more important to produce real nanometer-sized structures for semiconductor devices (e.g., quantum dot lasers) but also for nano-biomechanical applications like the so-called total analysis system implemented on one chip.We describe here a technique to create nanometer-sized structures in semiconductors and metals by the use of self-assembling diblock copolymers as nano-lithographic masks. Semiconductor quantum structures with very high aspect ratio of 1:10 were fabricated from III-V semiconductor heterostructures by anisotropic dry etching. In a first step, so-called diblock copolymer micelles were generated in a toluene solution. These micelles were loaded by a noblemetal salt. With a “Langmuir Blodgett” technique we can decorate complete wafers with a monolayer of highly ordered micelles, covering almost the complete surface. After treatment in a hydrogen plasma all of the organic components are removed and only crystalline metal clusters of ~12 nm size remain. This metal cluster mask can be used directly in a highly anisotropic chlorine dry etching process to etch cylinders in GaAs and its In and Al alloys. It is also possible to etch through a quantum well layer underneath the surface in order to produce quantum dots.By evaporating metals and applying a wet chemical image reversal process, we can invert the etched structure and generate a gauzy gold film with nano-holes inside. It is thinkable to use this porous gold film as a nano-filter in upcoming nano-biotechnology applications.
Anti-Epidermal Growth Factor Receptor Therapy in Head and Neck Squamous Cell Carcinoma: Focus on Potential Molecular Mechanisms of Drug Resistance
Authors: Boeckx Carolien , Baay Marc , Wouters An , Specenier Pol , Vermorken Jan B. , Peeters Marc , Lardon Filip 
Published: July 2013

AbstractTargeted therapy against the epidermal growth factor receptor (EGFR) is one of the most promising molecular therapeutics for head and neck squamous cell carcinoma (HNSCC). EGFR is overexpressed in a wide range of malignancies, including HNSCC, and initiates important signal transduction pathways in HNSCC carcinogenesis. However, primary and acquired resistance are serious problems and are responsible for low single-agent response rate and tumor recurrence. Therefore, an improved understanding of the molecular mechanisms of resistance to EGFR inhibitors may provide valuable indications to identify biomarkers that can be used clinically to predict response to EGFR blockade and to establish new treatment options to overcome resistance. To date, no predictive biomarker for HNSCC is available in the clinic. Therapeutic resistance to anti-EGFR therapy may arise from mechanisms that can compensate for reduced EGFR signaling and/or mechanisms that can modulate EGFR-dependent signaling. In this review, we will summarize some of these molecular mechanisms and describe strategies to overcome that resistance.
Selecting Patients With Locally Advanced Rectal Cancer for Neoadjuvant Treatment Strategies
Authors: Dewdney Alice , Cunningham David , Chau Ian 
Published: July 2013

Learning Objectives
Explain the use of MRI to stratify patients to undergo different neoadjuvant treatment strategies for locally advanced rectal cancer. Identify the benefits and risks of currently available neoadjuvant treatment strategies and appraise emerging treatment strategy. Identify tissue and imaging biomarkers that could predict tumor sensitivity to chemoradiation.
Exposure to Phtalates and Their Presence in Alcoholic Beverages
Authors: Jurica Karlo , Uršulin-Trstenjak Natalija , Vukić Lušić Darija , Lušić Dražen , Šmit Zdenko 
Published: July 2013

Ftalati su esteri ftalne kiseline i alifatskih alkohola koji se dodaju u plastične mase da bi se poboljšala njihova mekoća, savitljivost i rastezljivost. Zbog svojih fizičko-kemijskih svojstava ftalati su vrlo mobilni i lako migriraju iz plastičnih proizvoda u prostor koji ih okružuje, pa tako dospijevaju u okoliš te su stoga opasni za čovjeka.U radu su ukratko opisana svojstva i raspodjela ftalata u okolišu, toksični učinci na ljudsko zdravlje te zakonska regulativa vezana uz maksimalno dopuštene koncentracije ftalata u vodi za piće i u proizvodima namijenjenima dojenčadi, kao i dopušteni dnevni unos u ljudski organizam. Posebna pažnja posvećena je metodama određivanja ftalata u alkoholnim pićima te razinama ftalata s osvrtom na njihovu pojavnost i koncentracije u šljivovici koja se proizvodi u Hrvatskoj. Obuhvaćena je i tematika vezana za ftalate u denaturiranom alkoholu i neregistriranom alkoholu koji se ilegalno stavlja na tržište.U zaključku su navedene smjernice za učinkoviti nadzor nad putovima izloženosti ljudi ftalatima.
Is Burnout in Family Physicians in Croatia Related to Interpersonal Quality of Care?
Authors: Ožvačić Adžić Zlata , Katić Milica , Kern Josipa , Soler Jean Karl , Cerovečki Venija , Polašek Ozren 
Published: July 2013

The impact of physician burnout on the quality of patient care is unclear. This cross-sectional study aimed to investigate the prevalence of burnout in family physicians in Croatia and its association with physician and practice characteristics, and patient enablement as a consultation outcome measure.Hundred and twenty-five out of 350 family physicians responded to our invitation to participate in the study. They were asked to collect data from 50 consecutive consultations with their adult patients who had to provide information on patient enablement (Patient Enablement Instrument). Physicians themselves provided their demographic and professional data, including workload, job satisfaction, consultation length, and burnout [Maslach Burnout Inventory - Human Services Survey (MBI-HSS )]. MBI-HSS scores were analysed in three dimensions: emotional exhaustion (EE), depersonalisation (DP), and personal accomplishment (PA).Of the responding physicians, 42.4 % scored high for EE burnout, 16.0 % for DP, and 15.2 % for PA. Multiple regression analysis showed that low job satisfaction and more patients per day predicted high EE scores. Low job satisfaction, working more years at a current workplace, and younger age predicted high DP scores. Lack of engagement in education and academic work, shorter consultations, and working more years at current workplace predicted low PA scores, respectively (P<0.05 for each).Burnout is common among family physicians in Croatia yet burnout in our physicians was not associated with patient enablement, suggesting that it did not affect the quality of interpersonal care. Job satisfaction, participation in educational or academic activities and sufficient consultation time seem to reduce the likelihood of burnout.
Morphological assessments on the origin and supplied territory of the artery for the posterior renal segment
Authors: Iorga I. , Azis O. , Iliescu D.M. , Bordei P. 
Published: July 2013

Abstract
In 105 cases the posterior ramus originated from a renal artery bifurcated into anterior and posterior branches and in 78 cases from trifurcated renal artery. In 12 cases, the posterior ramus originated from a renal artery terminated with four branches. From the aorta, as supernumerary renal artery, the posterior branch originated in 7 cases, 3 cases as double and 4 cases as triple renal arteries. In 86 cases the posterior ramus originated from the anterior branch of the renal artery, superior or inferior or both. The arcade aspect was found in only 134 cases. A particular aspect of the arch is the italic “S” (or inverted italic “S”) or double arch, which we found in 24 cases. This type of posterior branch supplied the entire posterior valve, an aspect found in 11 cases. When the posterior branch was not in arcade, it was arranged transversally and ended by bi or trifurcation. The ending by bifurcation was found in 113 cases and by trifurcation in 17 cases. All of these cases, both the right and the left, supplied the entire posterior valve. In all cases, regardless of any aspect of the posterior branch, it supplied the entire posterior valve in 88 cases. The posterior branch supplied the superior pole in 250 cases, the inferior one in 181 and only the posterior mesorenal part, without participating in the supply of the two poles, in 233 cases.
South-Moravian Rural Borderland
Authors: Vaishar Antonín , Šťastná Milada , Trnka Pavel , Dvořák Petr , Zapletalová Jana 
Published: July 2013

AbstractThe South Moravian rural borderland has been studied as an example of peripheral countryside. It is defined by municipalities the cadastral districts of which border on the state frontiers. The borderland is considerably differentiated in dependence on the natural conditions, historic development, geographical position and subjective circumstances. The period after 1990 experienced a downturn in production sectors, development of the tertiary sector, quite positive demographic evolution with a positive migration balance (with some exceptions), further intensification of nature conservation and landscape protection, increased unemployment rate and lower standard of formal education. The strengths encompass the maintained and, in many cases, strictly protected landscape, suitable settlement structures with large villages, suitable conditions for agricultural activities, development of balneology and important transition position of the central part of the borderland. The weaknesses include, in particular, the distinctly seasonal character of tourism (short summer period), below-average education, poor condition of many local roads and exposedness of the territory to erosion. Opportunities include possibilities of international cooperation, support of non-production agriculture, demand for relevant forms of tourism, support of small and medium sized businesses. Threats are understood as the outflow of young and educated people, devastation of the environment through intensive farming and reduced economic competitive advantages. Strategies may consist in the preference of economic development or in focusing on the improvement of local inhabitants’ life quality.
10 Years After: the Impact of EU Accession on the Slovenian-Austrian Cross-Border Area in Pomurje Region
Authors: Marot Naja 
Published: July 2013

Abstract The articles derives from the research about potential socio-economic and landscape changes EU accession would bring for Slovenia as perceived by the local population in the selected region. The author analyzed which of the predicted changes have been also mirrored in the landscape and how removing the borders improved not just the quality but also the perception of the landscape. Special attention was given to the joined cross-border initiatives which aim at improving the local and regional economic conditions, advancing the agricultural practice and better environment in the region. On one hand, the accession has been along with the opportunities EU initiatives offer accepted as the positive change in the region, on the other it has requested several, sometimes unwanted adaptations in the local communities in order to comply with the EU policies and legislation.
Correction of location of boundaries in cadastre modernization process
Authors: Hanus Paweł 
Published: July 2013

Abstract
Modernization of lands and buildings register, which is run in Poland now, assumes capturing boundaries location data by various methods. They are: direct measurement preceded by determining of boundaries in the presence of parties, photogrammetric method, cartographic method, using existing maps being in analogue form. These methods not always assure accuracy. In the paper, an idea of correcting of location of boundary points which do not fulfil accuracy requirements has been presented. These corrections have been computed by assumption of invariability of parcel area revealed in register, so far. Such way of operation from one side would avoid many misunderstandings and difficulties by applying data collected in cadastre and from the other side will not disturb used procedures, which aim is to determine boundary of parcels with demanded accuracy.
Novatoriska iepakojuma ietekme uz piena pomādes konfekšu – šerbeta – kvalitāti uzglabāšanas laikā / Influence of Innovative Packaging on the Quality of Milk Pomade Sweets – Sherbet – during Storage
Authors: Ungure Eva , Muzniece-Brasava Sandra , Dukalska Lija 
Published: July 2013

Abstract
The objective of the research was to evaluate the quality of milk pomade sweet - sherbet - packaged in different packaging materials, using various packaging technologies. Four packaging materials were employed: two biodegradable films (Ceramis®-PLA coated with a barrier of pure silicon oxide [SiOx], and metallised NatureFlex 23NM), and two conventional films (metallised BOPET/PE, and Multibarrier 60 HFP as a control). Samples of sherbet were packaged using several technologies: active packaging (with incorporated ironbased oxygen scavenging sachets), modified atmosphere packaging consisting of 100% CO2, and surrounding air ambience (control). The physicochemical properties - moisture, hardness, and colour - were analysed before packaging and after 2, 4, 6, 8, 10, 12, 14, and 16 storage weeks. The samples were stored at room temperature - +21±1 °C. At the beginning of the experiment, the quality of sherbet was excellent in terms of taste, smell, colour, moisture content, and hardness expressed by cutting force. During the storage, those properties changed and the quality of the product decreased. The research suggests this can be explained by the loss of moisture in some samples leading to hardening of the product, which in its turn directly influenced the colour stability expressed by total colour difference ΔE*.