bluuebunny/crossref_metadata_2025_split huggingface dataset:
comparison of two multivalent modified live viral/bacterial combination vaccines in feedlot calves at ultra-high risk of developing undifferentiated fever/bovine respiratory disease
Authors: Hunsaker Breck D. , McMullen Christopher A. , Stamm Courtney G. , Perrett Tye , Hannon Sherry J. , Bryant Lonty K. , Booker Calvin W. 
Published: August 2024

Vaccine 1 (VAC1 group) and Vaccine 2 (VAC2 group) are com­mercially available vaccines labeled for the control of bovine respiratory disease (BRD) in beef cattle. There are limited data from large-scale commercial feedlot trials comparing VAC1 and VAC2 arrival processing vaccination pro­grams. The objective of this study was to evaluate the relative effects of VAC1 and VAC2 arrival processing vacci­nation programs on animal health, feedlot performance and carcass characteristic outcomes in feedlot calves at ultra-high risk of developing undifferentiated fever/BRD under large-scale commercial production conditions. Animals were randomly allocated at feedlot arrival to 1 of 2 experimental groups: VAC1 or VAC2. Animals in the VAC1 group (6 multi-pen lots; 3,001 animals) received a bovine rhinotracheitis-virus diarrhea-parainfluenza 3-respiratory syncytial virus-Mannheimia hae­molytica-Pasteurella multocida vaccine per animal once at allocation. Animals in the VAC2 group (6 multi-pen lots; 3,005 animals) received a bovine rhinotracheitis-virus diarrhea-parainfluenza 3-respiratory syncytial virus vaccine with a Mannheimia haemolytica toxoid per animal once at allocation. Vaccines differed regarding viral strains, bacterial protection, means for providing bacterial immunity, and adjuvant use. Animals were housed by experi­mental group in commercial feedlot pens and followed from allocation until slaughter. Although histophilosis mortality was higher in the VAC1 group compared to the VAC2 group (P = 0.040), no statistical differences were detected in overall mor­tality or any of the other outcome variables (P ≥ 0.050). The relative cost effectiveness of each arrival processing vaccina­tion program in the study population is therefore dependent on relative program cost.
The Effectiveness of Memory Strategies to Improve Students' Speaking Skills
Authors: Rahayu Arum Putri , Sholikhah Masriatus 
Published: August 2024

This research studies the memory strategies used by the second semester STAI Ma’arif Magetan students to improve their speaking skills through involvement in English vocabulary. The purpose of this research is to find out the types of strategies and students' preferences in using strategic memory to improve their speaking skills. The data consists of memory strategies used by STAI Ma’arif Magetan students. The data source consisted of 30 second semester students. The memory strategy questionnaire was carried out for the data collection process. Data analysis was carried out using several steps such as data reduction, displaying data, and drawing conclusions. The research results showed: (1) students used ten indicators of strategic memory (grouping, associating, placing new words into a context, using images, semantic solvers, using keywords, representing sounds in memory, structural displays, using physical responses or sensation, and using mechanical techniques); (2) students' preferences in using memory strategies to place new words into context.
Complexity of hydrometeorological variables: false nearest neighbour algorithm
Authors: Saji Namitha Elza , Jothiprakash V. , Sivakumar Bellie 
Published: August 2024

ABSTRACT
This study examines the complexity of hydrometeorological variables in the Savitri River basin in India. Specifically, it estimates the dimensionality of daily rainfall, runoff, maximum temperature, minimum temperature, pan evaporation, relative humidity, sunshine duration, and wind speed observed during 2000–2010 at two stations (Kangule and Birwadi). The false nearest neighbour (FNN) algorithm is employed to estimate the dimensionality of each variable. The dimensionality represents the number of variables dominantly governing the system. The FNN dimension values of the eight daily hydrometeorological series from each station range between 4 and 7, which may be considered as exhibiting a medium level of complexity. Among the eight series, wind speed is found to be the least complex, whereas minimum temperature and sunshine duration are the most complex. An attempt is also made to examine the effect of temporal scale on the complexity of the hydrometeorological variables, by analysing the hourly rainfall and runoff series. The results indicate that, for both rainfall and runoff, hourly data exhibits greater complexity, with two to three additional influential variables. The present results have important implications for hydrometeorological modelling, prediction, and disaster management in the small and flood-prone Savitri River basin.
Water, environment, and health nexus: understanding the risk factors for waterborne diseases in communities along the Tano River Basin, Ghana
Authors: Yeboah Saeed Ibn Idris Kofi , Antwi-Agyei Prince , Kabo-Bah Amos T. , Ackerson Nana Osei Bonsu 
Published: August 2024

ABSTRACT

Freshwater pollution is a major concern in Ghana, directly impacting human health. However, the underlying drivers of exposure and risks are not comprehensively understood, emphasizing the severity and impact of these diseases. This study assessed the interaction between water and human health, specifically focusing on the risk factors for waterborne diseases and the drivers of water pollution among residents near the Tano River Basin, Ghana. A sample size of 400 households was selected from five communities within the basin based on their proximity to the Tano River. In addition, the study combined both spatial and non-spatial data sources to map potential flood zones for the basin. The study found that inadequate sanitation, poor hygiene practices, and contamination from illegal mining were the primary causative factors of waterborne diseases. Additionally, floods and improper waste management significantly contributed to disease outbreaks. The flood susceptibility analysis indicated that areas highly susceptible to flooding cover 21.2% of the basin, predominantly in the southern part. The results highlight the urgent need for comprehensive interventions to address the drivers of waterborne diseases. This study will contribute to the local authorities in developing plans to prevent waterborne diseases and mitigate their economic and public health impacts.
ZFC3H1 as an Indicator of Poor Prognosis in Hepatocellular Carcinoma:
Bioinformatic Analysis and Experimental Verification
Authors: Zhao Jiaxin , Wang Cheng , Wu Rui , Fang Zheyu , Dong Rui , Zhou Jie , Hu Zhenhua 
Published: August 2024

Background:
Zinc finger C3H1-type containing (ZFC3H1) might regulate RNA processes.
However, research lacks the prognostic value of ZFC3H1 in hepatocellular carcinoma
(HCC).

Methods:
The study analyzed ZFC3H1 expression in HCC cells and its correlation with patient
prognosis using transcriptomics, immunohistochemistry, and quantitative real-time reverse transcription
PCR, as well as single-cell RNA expression data. Additionally, Gene Ontology and
Kyoto Encyclopedia of Genes and Genomes enrichment analyses were used to investigate the
potential ZFC3H1-related cellular functions and signaling pathways. The impact of ZFC3H1 expression
on the tumor microenvironment and tumor mutational burden (TMB) was assessed using
the ESTIMATE algorithm. Cell-based assays, including cell counting kit 8, proliferation,
colony formation, cell cycle, wound healing, and Transwell assays, were conducted to evaluate
the influence of ZFC3H1 on hepatocellular carcinoma proliferation and migration.

Results:
ZFC3H1 is upregulated in HCC and linked to tumor progression. High ZFC3H1 expression
is a prognostic risk factor for HCC, according to Kaplan-Meier and Cox regression analyses.
ESTIMATE analysis suggested that ZFC3H1 reduces immune cell infiltration and increases
the TMB. Patients with low ZFC3H1 expression might respond better to immunotherapy.
High ZFC3H1 expression is associated with increased half-maximal inhibitory concentration
(IC50) of sorafenib. Functional experiments demonstrated that reducing ZFC3H1 expression inhibited
HCC cell proliferation and migration.

Conclusion:
ZFC3H1 is upregulated in HCC, promoting the proliferation and migration of liver
cancer cells, impacting the prognosis of HCC patients and the effectiveness of immunotherapy.
ZFC3H1 might serve as a therapeutic target and biomarker for HCC.
Malignant Pleural Mesothelioma: Socioeconomic and Clinical Aspects
Authors: Pandey Swaroop Kumar , Yadav Neha , Mishra Anuja , Sohal Jagdip Singh , Thakur Komal , Dwivedi-Agnihotri Hemlata 
Published: August 2024

Abstract:
Pleural malignancy is an aggressive malignancy of the pleural surface and is primarily
associated with asbestos exposure. Malignant pleural mesothelioma (MPM) is an invasive form of
mesothelioma and resistant to conventional therapy. Recently, it has also been reported that carbon
nanotube (CNTs) exposure can induce inflammation and fibrosis of the pleura and induce tumor
development pre-clinical model. Although several strategies like immunotherapy (Dendritic
cells, immune checkpoint inhibitors, CAR-T cell therapy), and viral therapy are being employed
for the management of MPM. However, poor prognosis and limited treatment options make the
problem worse. Apart from clinical challenges, industrial and socioeconomic challenges are key
factors for the patients as they are mainly industry workers or their associates. This article is focused
on industrial, clinical and socioeconomic challenges associated with malignant pleural mesothelioma
(MPM) patients and available opportunities.
Formulation and Evaluation of Quercetin Loaded Sago Starch Nanoparticles
Authors: Kumar Manish , Kumar Dharmendra 
Published: August 2024

Aim:
Formulation and evaluation of the QLSS nanoparticles as a drug delivery system.

Background:
Poor drug solubility and permeability, particularly in BCS Class IV drugs, hamper
their pharmacokinetics and targeted action. This study aims to address this by utilizing starch nanoparticles
as a novel carrier for enhanced delivery and improved bioavailability.

Objective:
Formulation of the QLSS nanoparticles and their % drug entrapment, drug loading, average
particle size, surface morphological examination, in-vitro drug release study, and cytotoxicity
activity using an MTT assay against the A549 cancer cell line.

Method:
QLSS nanoparticles were prepared by the nanoprecipitation technique with some modifications,
&assessment, including surface morphological analysis, drug loading, drug entrapment
percentage, average particle size, in-vitro drug release study, and cytotoxicity activity.

result:
The average particle size and surface morphology of prepared optimized QLSS nanoparticles (QLSS 3) were found to be approximately 43.24–113.51 nm and spherical in shape with a 292.1nm of Z-average size. The percentage yield was found to be 80% of QLSS-3. The percentages of drug encapsulation efficiency and loading capacity were found to be 68% and 42.5%, respectively. The drug in-vitro release outcomes were found to be 96.12±1.8% within 12 hours. 10µg/ml of QLSS 3 inhibited 66.31% of A549 cancer cells.

Result:
The average particle size and surface morphology of prepared optimized QLSS nanoparticles
(QLSS 3) were found to be approximately 43.24-113.51 nm and spherical in shape with a
292.1nm Z-average size. The percentage yield was found to be 80 ± 2.0% of QLSS-3. Loading capacity
and the percentages of drug encapsulation efficiency were found to be 42.5 ± 1.2% and 68
± 2.2%, respectively. The results of the in-vitro drug's release were found to be 96.12 ± 1.8%
within 12 hours. 10μg/ml of QLSS 3 inhibited 66.31 ± 1.4% of A549 cancer cells.

Conclusion:
In this research study, sago starch was used for the first time as a drug carrier for
quercetin. The results of the studies confirmed the improvement in pharmacokinetic parameters of
the BCS-IV class drug.
Anxiety and Depression Predicted Quality of Life during
Menopause
Authors: Simbar Masoumeh , Nazarpour Soheila , Jafari Torkamani Zahra , Dodel Andarvar Khadijeh , Alavi Majd Hamid 
Published: August 2024

Background:
Depression and anxiety are common during menopause and may
affect the quality of life (QoL) during menopause.

Objective:
This study aims to assess the potential predictivity of depression and anxiety
with quality of life (QoL) during the postmenopausal period.

Methods:
This was a cross-sectional study on 285 postmenopausal women in Tehran- Iran.
Quota sampling was used to recruit eligible women from health centers in Tehran. The
tools for data collection were four questionnaires: demographic, WHQOL-BREF, Beck
depression, and Speilberger questionnaires. Data were analyzed using SPSS-V23 by conducting
Pearson correlation and multiple linear regression.

Results:
The average age and duration of menopause of the participants were 55.10±3.91
years old (Mean±SD) and 5.90±4.38 years, respectively. Mild to severe anxiety and depression
were found among 84.6 and 55.8 percent of the participants, respectively. There
was a negative and significant correlation between QoL and all its dimensions with depression
and anxiety scores (p < 0.001). There was a significant correlation between QoL and
the education level of the woman and her husband, income sufficiency, the number of
children, and housing status (p < 0.001). Multiple linear regression model showed QoL is
predicted by anxiety (B=-0.82, p < 0.001) and depression (B=-0.47, p < 0.001) as well as
income sufficiency (B=2.26, p < 0.001) and husband’s educational level (B=1.87, p <
0.017) during menopause.

Conclusion:
Depression and anxiety are common complications during menopause that
affect the women's QoL. Therefore, the promotion of psychological health to reduce depression
and anxiety should be considered for future health plans for improving QoL during
menopause.
Exploring the Experiences of Community-Dwelling Older Adults on Using Wearable Monitoring Devices With Regular Support From Community Health Workers, Nurses, and Social Workers: Qualitative Descriptive Study
Authors: Wong Arkers Kwan Ching , Bayuo Jonathan , Su Jing Jing , Chow Karen Kit Sum , Wong Siu Man , Wong Bonnie Po , Lee Athena Yin Lam , Wong Frances Kam Yuet 
Published: August 2024

Background
The use of wearable monitoring devices (WMDs), such as smartwatches, is advancing support and care for community-dwelling older adults across the globe. Despite existing evidence of the importance of WMDs in preventing problems and promoting health, significant concerns remain about the decline in use after a period of time, which warrant an understanding of how older adults experience the devices.

Objective
This study aims to explore and describe the experiences of community-dwelling older adults after receiving our interventional program, which included the use of a smartwatch with support from a community health workers, nurses, and social workers, including the challenges that they experienced while using the device, the perceived benefits, and strategies to promote their sustained use of the device.

Methods
We used a qualitative descriptive approach in this study. Older adults who had taken part in an interventional study involving the use of smartwatches and who were receiving regular health and social support were invited to participate in focus group discussions at the end of the trial. Purposive sampling was used to recruit potential participants. Older adults who agreed to participate were assigned to focus groups based on their community. The focus group discussions were facilitated and moderated by 2 members of the research team. All discussions were recorded and transcribed verbatim. We used the constant comparison analytical approach to analyze the focus group data.

Results
A total of 22 participants assigned to 6 focus groups participated in the study. The experiences of community-dwelling older adults emerged as (1) challenges associated with the use of WMDs, (2) the perceived benefits of using the WMDs, and (3) strategies to promote the use of WMDs. In addition, the findings also demonstrate a hierarchical pattern of health-seeking behaviors by older adults: seeking assistance first from older adult volunteers, then from social workers, and finally from nurses.

Conclusions
Ongoing use of the WMDs is potentially possible, but it is important to ensure the availability of technical support, maintain active professional follow-ups by nurses and social workers, and include older adult volunteers to support other older adults in such programs.
COVID-19–Related Social Isolation, Self-Control, and Internet Gaming Disorder Among Chinese University Students: Cross-Sectional Survey
Authors: Guo Yufang , Yue Fangyan , Lu Xiangyu , Sun Fengye , Pan Meixing , Jia Yannan 
Published: August 2024

Background
Internet gaming disorder among university students has become a great concern for university counsellors worldwide since the COVID-19 pandemic. The factors influencing the development of internet gaming disorder in students during the COVID-19 pandemic could be different from those before the pandemic.

Objective
This study aims to explore the associations among social isolation, self-control, and internet gaming disorder in Chinese university students and to examine whether self-control mediates the positive effects of social isolation on internet gaming disorder.

Methods
A cross-sectional survey was employed to collect data from university students in Shandong province of China from April to September 2022. The Isolation subscale of the Self-Compassion Scale, Self-Control Scale, and Internet Gaming Disorder Scale were used to assess the social isolation, self-control, and internet gaming disorder among university students, respectively. Models 4 and 5 of PROCESS software were used to analyze the mediating role of self-control and the moderating role of gender on the association between social isolation and internet gaming disorder.

Results
A total of 479 students were recruited from 6 universities located in 3 different regions of Shandong, China. Students had low levels of internet gaming disorder and moderate levels of social isolation and self-control, with mean scores of 8.94 (SD 9.06), 12.04 (SD 3.53), and 57.15 (SD 8.44), respectively. Social isolation was positively correlated with internet gaming disorder (r=0.217; P<.001), and self-control was negatively correlated with social isolation (r=–0.355; P<.001) and internet gaming disorder (r=–0.260; P<.001). Self-control played a mediating role in the association between social isolation and internet gaming disorder (β=–.185, 95% CI –.295 to –.087). The effects of social isolation on internet gaming disorder among female students were lower than those among male students.

Conclusions
Self-control was a mediator in the association between social isolation and internet gaming disorder. Moreover, gender played a moderating role in the association between social isolation and internet gaming disorder. This study highlights the need to alleviate the development of internet gaming disorder among students during a pandemic, especially that of male students. Effective interventions that lessen social isolation and promote self-control should be developed.
Exploring Cancer Incidence Trends by Age and Sex Among 14.14 Million Individuals in China From 2007 to 2021: Population-Based Study
Authors: Yuan Yingchao , Liu Chang , Guo Moning , Xin Zhong , Chen Guanjie , Yang Yue , Zheng Jianpeng , Zang Bai , Yang Jinkui 
Published: August 2024

Background
Sex is a crucial factor in the development, progression, and treatment of cancer, making it vital to examine cancer incidence trends by sex for effective prevention strategies.

Objective
This study aimed to assess the incidence of cancer in China between 2007 and 2021, with a focus on sex-based trends.

Methods
A population-based cancer registry comprising 14.14 million individuals was maintained between 2007 and 2021 by the Beijing Municipal Health Big Data and Policy Research Center. The age-standardized rates (ASRs) of cancers were calculated using the Segi population. The average annual percentage of change (AAPC) was evaluated using the joinpoint regression model, while the Bayesian age-period-cohort model was used to predict cancer incidence in the next 10 years.

Results
From 2007 to 2021, the study included 651,342 incident patients with cancer, of whom 51.2% (n=333,577) were women. The incidence indicated by the ASR for all cancers combined was 200.8 per 100,000 for women and 184.4 per 100,000 for men. The increase in incidence indicated by AAPC for all malignancies combined significantly increased in women between 2007 and 2021 (AAPC=3.1%; P<.001), whereas it remained constant in men (AAPC=0.3%; P=.30). Although the overall incidence of all cancers indicated by AAPC increased in young men (AAPC=3.2%; P=.01), the greatest increase was observed among young women (AAPC=6.1%; P<.001). The incidence rate ratio for cancer in women increased among subsequent younger generations compared with patients born in the 1962-1966 cohort. The ASR in women will increase 1.6-fold over the next 10 years, with women having twice the incidence rate of men by 2031.

Conclusions
The rising incidence of cancer among women in China has become a growing concern, emphasizing the need for increased efforts in cancer prevention and early screening, especially among young women.
Use of Financial Incentives to Promote Adolescent Type 1 Diabetes Self-management: A Pilot Randomized Controlled Trial
Authors: Malik Faisal S. , Chen Tom , Manzueta Maria , Yi-Frazier Joyce P. , Pihoker Catherine , LeBlanc Jessica L. , Shah Seema K. , Wright Davene R. 
Published: August 2024

OBJECTIVE
To evaluate whether financial incentives lead to improvement in self-management behaviors and glycemia in adolescents with type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS
Adolescents (12- to 18-year-olds) with T1D selected incentivized self-management behavior and clinical outcome goals in a three-treatment (gain frame, loss frame, no incentives) crossover randomized controlled trial. Participants could earn up to $180 in each 12-week incentive treatment arm.

RESULTS
Compared with a mean 41% behavioral goal attainment within the nonfinancial incentives arm, mean behavioral goal attainment under gain and loss frames was 50% (P &lt; 0.01) and 45% (P &lt; 0.01), respectively. Mean time in range (TIR) in gain frame and loss frame arms was higher 43% (P &lt; 0.01) and 42% (P &lt; 0.01), respectively, compared with when not receiving financial incentives (38%). There was no difference in A1C among the three arms.

CONCLUSIONS
Financial incentives can improve diabetes self-management behaviors and TIR in adolescents with T1D in the short-term.