bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Occupational Exposures on Lung Cancer Susceptibility: A Study of Gene–Environment Interaction Analysis
Authors: Malhotra Jyoti , Sartori Samantha , Brennan Paul , Zaridze David , Szeszenia-Dabrowska Neonila , Świątkowska Beata , Rudnai Peter , Lissowska Jolanta , Fabianova Eleonora , Mates Dana , Bencko Vladimir , Gaborieau Valerie , Stücker Isabelle , Foretova Lenka , Janout Vladimir , Boffetta Paolo 
Published: January 2015

Abstract
Background: Occupational exposures are known risk factors for lung cancer. Role of genetically determined host factors in occupational exposure–related lung cancer is unclear.
Methods: We used genome-wide association (GWA) data from a case–control study conducted in 6 European countries from 1998 to 2002 to identify gene–occupation interactions and related pathways for lung cancer risk. GWA analysis was performed for each exposure using logistic regression and interaction term for genotypes, and exposure was included in this model. Both SNP-based and gene-based interaction P values were calculated. Pathway analysis was performed using three complementary methods, and analyses were adjusted for multiple comparisons. We analyzed 312,605 SNPs and occupational exposure to 70 agents from 1,802 lung cancer cases and 1,725 cancer-free controls.
Results: Mean age of study participants was 60.1 ± 9.1 years and 75% were male. Largest number of significant associations (P ≤ 1 × 10−5) at SNP level was demonstrated for nickel, brick dust, concrete dust, and cement dust, and for brick dust and cement dust at the gene-level (P ≤ 1 × 10−4). Approximately 14 occupational exposures showed significant gene–occupation interactions with pathways related to response to environmental information processing via signal transduction (P &lt; 0.001 and FDR &lt; 0.05). Other pathways that showed significant enrichment were related to immune processes and xenobiotic metabolism.
Conclusion: Our findings suggest that pathways related to signal transduction, immune process, and xenobiotic metabolism may be involved in occupational exposure–related lung carcinogenesis.
Impact: Our study exemplifies an integrative approach using pathway-based analysis to demonstrate the role of genetic variants in occupational exposure–related lung cancer susceptibility. Cancer Epidemiol Biomarkers Prev; 24(3); 570–9. ©2015 AACR.
Cumulative Effect of Psychosocial Factors in Youth on Ideal Cardiovascular Health in Adulthood
Authors: Pulkki-Råback Laura , Elovainio Marko , Hakulinen Christian , Lipsanen Jari , Hintsanen Mirka , Jokela Markus , Kubzansky Laura D. , Hintsa Taina , Serlachius Anna , Laitinen Tomi T. , Pahkala Katja , Mikkilä Vera , Nevalainen Jaakko , Hutri-Kähönen Nina , Juonala Markus , Viikari Jorma , Raitakari Olli T. , Keltikangas-Järvinen Liisa 
Published: January 2015

Background—
The American Heart Association has defined a new metric of ideal cardiovascular health as part of its 2020 Impact Goals. We examined whether psychosocial factors in youth predict ideal cardiovascular health in adulthood.

Methods and Results—

Participants were 477 men and 612 women from the nationwide Cardiovascular Risk in Young Finns Study. Psychosocial factors were measured from cohorts 3 to 18 years of age at the baseline of the study, and ideal cardiovascular health was examined 27 years later in adulthood. The summary measure of psychosocial factors in youth comprised socioeconomic factors, emotional factors, parental health behaviors, stressful events, self-regulation of the child, and social adjustment of the child. There was a positive association between a higher number of favorable psychosocial factors in youth and greater ideal cardiovascular health index in adulthood (β=0.16;
P
<0.001) that persisted after adjustment for age, sex, medication use, and cardiovascular risk factors in childhood (β=0.15;
P
<0.001). The association was monotonic, suggesting that each increment in favorable psychosocial factors was associated with improvement in cardiovascular health. Of the specific psychosocial factors, a favorable socioeconomic environment (β=0.12;
P
<0.001) and participants’ self-regulatory behavior (β=0.07;
P
=0.004) were the strongest predictors of ideal cardiovascular health in adulthood.

Conclusions—
The findings suggest a dose-response association between favorable psychosocial factors in youth and cardiovascular health in adulthood, as defined by the American Heart Association metrics. The effect seems to persist throughout the range of cardiovascular health, potentially shifting the population distribution of cardiovascular health rather than simply having effects in a high-risk population.
Schistonchus zealandicus n. sp. (Nematoda: Aphelenchoididae) associated with Ficus macrophylla in New Zealand
Authors: Zhao Zengqi , Li Dongmei , Davies Kerrie A. , Ye Weimin 
Published: January 2015

Schistonchus zealandicus n. sp. was recovered from the sycones of Ficus macrophylla from St Helier’s Bay, Mt Wellington, and St Johns, suburbs of Auckland, New Zealand. It is characterised by having the opening of the excretory pore located just posterior to the anterior end of the nematode but anterior to the conus level of the stylet, a short post-vulval uterine sac (10-18 μm or 0.4-0.7 vulval body diam. long), presence of two incisures in the lateral field with many broken, non-defined lines between them, rose-thorn-shaped spicule, three pairs of subventral papillae on the male tail (one pair adcloacal on the anterior lip, one pair slightly posterior to mid-tail length, and one pair close to tail tip), a distinctive mucron on the male tail, apparent biogeographical range, and its association with F. macrophylla. The absence of a lip sector disc suggests that it is close to S. altermacrophylla, S. aureus and S. laevigatus. Molecular phylogeny of near full length small subunit and D2-D3 expansion segments of the large subunit rRNA genes supports the proposal of S. zealandicus n. sp. as a new species.
Formation of Thin Films of Densely Packed [60]Fullerene–Diaminoethane Adduct Microparticles at a Liquid/Liquid Interface and Their Photoelectrochemical Applications
Authors: Banya Shoto , Akiyama Tsuyoshi , Izumoto Daisuke , Suzuki Atsushi , Oku Takeo 
Published: January 2015

Abstract
Thin films of [60]fullerene–1,2-diaminoethane adduct microparticles (C60P) were fabricated via a liquid/liquid interface precipitation. The energy level of the lowest unoccupied molecular orbital (LUMO) of the C60P was evaluated by electrochemical analysis. The additional tetraphenylporphyrin substantially enhanced the photocurrent from the C60P-thin-film-modified electrode.
Let's talk about sex: A pilot randomised controlled trial of a structured sexual rehabilitation programme in an Australian stroke cohort
Authors: Sansom Joshua , Ng Louisa , Zhang Nina , Khan Fary , Couldrick Lorna 
Published: January 2015

Background:Sexual dysfunction is a common problem after stroke. Sexual rehabilitation is recommended but little is known about the types or effectiveness of this intervention.Aim:To assess the effectiveness of a structured sexual rehabilitation programme alongside the use of written material in comparison with the use of written material alone, and to evaluate the impact of both interventions on sexual and psychological function in an Australian stroke cohort.Methods:Twelve participants (patients n=10; partners n=2) were randomly assigned to an intervention (n=4) or control (n=6) group. Standardised measurements were used to assess: sexual functioning (Changes in Sexual Function Questionnaire Short-Form) (CSFQ-14) (primary outcome); psychological functioning (Depression, Anxiety and Stress Scale) (DASS); physical functioning (Functional Independence Measure); and quality of life (Stroke and Aphasia Quality of Life scale–39-item generic version) (SAQOL-39g). All measures were assessed at baseline (T1) and six weeks after the programme (T2).Results:There was no significant difference between the intervention and control groups at T2 in sexual functioning (CSFQ-14), psychological functioning (DASS) and quality of life (SAQOL-39g); however, there was a trend in both groups toward improvement in all outcome measures at T2 compared with T1.Conclusion:This preliminary study demonstrates the feasibility and importance of providing sexual rehabilitation following stroke, and that sexual rehabilitation may improve sexual and psychological functioning and quality of life. Further studies are needed to confirm these findings for stroke survivors and their partners to address sexual issues that may arise and perceived rehabilitation needs.
Martial arts practice in community-based rehabilitation: A review
Authors: Rajan Pavithra , Tsang Hector WH 
Published: January 2015

Aim: Martial arts are forms of self-defence or attack that have been modified for modern sport and exercise, and are reported to provide health benefits for people who practise them. This article discusses the evidence base for the use of martial arts, such as tai chi, karate and taekwondo, in the rehabilitation process and how they may play a role in community-based rehabilitation. Findings: Tai chi is a low-impact form of exercise that can help to: reduce the risk of falls among community-dwelling stroke survivors; lower blood pressure in patients with heart failure; and improve the wellbeing of breast cancer survivors. Karate is a more rigorous form of martial arts than tai chi and research has highlighted its benefits for children, including: improved memory and self-esteem for those with epilepsy; reduced stereotypy among children with autism; and improved developmental skills among schoolchildren with and without special needs. Taekwondo is another rigorous martial art form that has potential health benefits; limited research has been conducted into this, with a study reporting improvements in class behaviour and academic performance among children who practise it. Conclusions: While each martial art form has its own positive health benefits, future research must be undertaken to compare the effectiveness of different martial art forms in different communities.
Extrapolation of short-time drying shrinkage tests based on measured diffusion size effect: concept and reality
Authors: Bažant Zdeněk P. , Donmez Abdullah 
Published: January 2015

Abstract
To check the shrinkage of the concrete considered for a design and construction project, only a limited time such as 1–3 months is usually available. So, a short-time shrinkage test must be extrapolated to much longer times, which has been known to be a difficult problem. To obtain a dependable extrapolation, it was proposed to use weight measurements of the water loss of the test specimens. However, recently some problems with this concept have been identified. The present article proposes another concept relying on the diffusion size effect in shrinkage. In a much smaller companion specimen, it is possible to reach within 1–3 months the concave part of the shrinkage curve plotted in logarithmic time scale, in which the asymptotic value is closely approached. The method is examined using the available published data on the shrinkage of specimens of different sizes. Because the size difference in the available data is too small, the method is also examined using artificial small-size data obtained by scaling according to the diffusion theory. Both cases indicate overall improvement in predicting the final asymptotic values. However, although the extrapolation is clearly better than the traditional extrapolation “by eye” or by fitting a formula to one-size data, some non-negligible discrepancies are still observed, and it is not clear whether the size effect method is better than the water loss method. In the face of this reality, further studies are recommended using tests of combined drying and autogenous shrinkages, with greater size differences of drying specimens and a refined evaluation taking into account secondary influences such as differences in cracking, hydration aging, and the inevitable effect of autogenous shrinkage in the specimen core before it is reached by the drying front. Until such studies clarify the problem, taking the more conservative result from the extrapolations by the size-effect and weight-loss methods is recommended as better than intuitive extrapolation “by eye”.
Error simulations of uncorrected NDVI and DCVI during remote sensing measurements from UAS
Authors: Chiliński Michał T. , Ostrowski Marek 
Published: January 2015

Abstract
Remote sensing from unmanned aerial systems (UAS) has been gaining popularity in the last few years. In the field of vegetation mapping, digital cameras converted to calculate vegetation index (DCVI) are one of the most popular sensors. This paper presents simulations using a radiative transfer model (libRadtran) of DCVI and NDVI results in an environment of possible UAS flight scenarios. The analysis of the results is focused on the comparison of atmosphere influence on both indices. The results revealed uncertainties in uncorrected DCVI measurements up to 25% at the altitude of 5 km, 5% at 1 km and around 1% at 0.15 km, which suggests that DCVI can be widely used on small UAS operating below 0.2 km.
Developing a hot-water drill system for the WISSARD project: 3. Instrumentation and control systems
Authors: Burnett Justin , Rack Frank R. , Blythe Daren , Swanson Pat , Duling Dennis , Gibson Dar , Carpenter Chad , Roberts Graham , Lemery Jeff , Fischbein Steve , Melby Adam 
Published: January 2015

AbstractThe WISSARD (Whillans Ice Stream Subglacial Access Research Drilling) traversable hot-water drill system was designed to create various-diameter ice boreholes to a depth of >800 m, with most major components being controllable from a single user interface. The drill control system operates four low-pressure pumps for water generation and circulation, two hot-water generation units containing a total of six diesel burner modules with integrated high-pressure pumps, three winches (one with independent level-wind motor), a four-motor linear traction drive, and a large number of analog and digital sensors to monitor system performance and cleanliness. Due to development time constraints the control system design focused on utilizing commercial off-the-shelf components, while being highly modular, easily expandable and rapidly deployable. Additional emphasis was placed on providing redundant manual operator controls and maintaining a low degree of system automation to avoid dependence on software control loops for first-season deployment. The result of this design paradigm was a control system that was taken from concept to full operation in <6 months, successfully performing in the field without insurmountable problems.
Le corps de l'indicible
Authors: Barouh-Cohen Stéphanie 
Published: January 2015

Le processus d’adolescence engage des remaniements identitaires et identificatoires qui nécessitent un travail de psychisation indispensable pour assurer un sentiment de continuité. Son achoppement fait courir au sujet le risque de la domination par la « fonction désobjectalisante » de son économie psychique, obturant par là même toute forme de créativité et d’expression du vivant. Le travail de l’analyse pourrait alors emprunter la voie de la sensorialité à partir du déplacement dans le transfert des impressions sensorielles non assimilées, au plus près du « corps de l’indicible », entre impasse et créativité.
Diderot philosophe des sciences
Authors: Pépin François 
Published: January 2015

Diderot est davantage connu comme écrivain et penseur matérialiste que comme philosophe des sciences. Mais, quoiqu’il ne fût pas un savant, son intérêt pour les sciences et leur importance dans son travail encyclopédique et philosophique justifient cette idée. Il s’agit d’abord d’esquisser les traits principaux du « Diderot homme de sciences », pour reprendre les mots de Jean Mayer. En m’appuyant sur les études plus ou moins récentes sur le sujet, je voudrais proposer un bilan personnel axé sur la manière dont Diderot pratique les sciences et la réflexion philosophique à leur égard. Loin d’en faire un usage doctrinal exploitant des résultats scientifiques pour justifier des thèses métaphysiques élaborées par ailleurs, Diderot pense avec les sciences, médite sur leur esprit, se soucie des gestes des savants et des conditions concrètes du développement du savoir.
Des graphes et des voix
Authors: Abramovici Jean-Christophe 
Published: January 2015

La fameuse « Préface-annexe » de La Religieuse reprend le texte de la « confession » que, dix ans plus tôt, Grimm avait publié dans son périodique pour confesser son rôle dans la mystification qui avait été jouée au marquis de Croismare. La « reprise » de Diderot accompagne la résurrection du roman que Grimm avait enterré, sans se soucier des affirmations contradictoires qui en résultent. La polygraphie de Diderot est polyphonie ; elle participe de la représentation des pouvoirs de l’écriture, que conquiert Suzanne, l’héroïne du roman.
La fracture économique
Authors: Jacquet Denis 
Published: January 2015

Libérons la France ! Nous disposons de forces extraordinaires, trop souvent gâchées par une classe politique qui, par manque de courage, d’audace, et surtout de connaissance de la réalité de ceux qui restent pourtant, l’unique espoir de retour de la croissance : les entrepreneurs et, de façon plus large, la société dite « civile ». Le pays a besoin d’air frais, d’esprits neufs, dédiés au bien public, sans obsession du pouvoir, mais rien n’est prévu pour laisser ce courant d’air salvateur enrichir leur travail. Quelles sont les principales décisions à prendre pour le rebond de la France ? De quel courage faudra t-il faire preuve pour l’offrir à un pays qui a tant d’atouts pour réussir, mais les gâche inexorablement ? Denis Jacquet trace les lignes de force d’une nouvelle culture, qui doit précéder toutes les mesures que nous pourrions prendre, qui ne seraient autrement, que des coups d’épées dans l’eau.
France : ajustements graduels
Authors: Département analyse et prévision  , Heyer Éric , Cochard Marion , Ducoudré Bruno , Péléraux Hervé 
Published: January 2015

En 2013, l’économie française a connu une croissance de 0,3 % en moyenne annuelle, ce qui lui a permis de retrouver en fin d’année le niveau de production atteint six ans plus tôt. Entre 2008 et le début de 2011, l’économie française a bien résisté : au premier trimestre 2011, le PIB français avait même quasiment retrouvé son niveau d’avant-crise et n’accusait que très peu de retard vis-à-vis de l’Allemagne et des États-Unis. La donne a changé à partir du deuxième trimestre 2011 lorsque les premiers effets de la politique de rigueur sont apparus. La dynamique de reprise s’est interrompue : l’activité a alors connu une croissance annuelle positive, certes, mais proche de zéro jusqu’en 2013. Depuis quelques mois, le paysage conjoncturel s’est notablement éclairci en Europe avec un retour de la croissance et un raffermissement des indicateurs conjoncturels. Pour ce qui est de la France, les enquêtes de conjoncture témoignent également d’un retour de la confiance dans les secteurs productifs. Le relâchement de l’austérité permettra à l’économie française de prolonger ce mouvement positif : en 2014 et 2015, le PIB français croîtrait respectivement de 1,2 et 1,6 %. L’écart de production se refermant à peine, la phase conjoncturelle en cours et anticipée ne peut être qualifiée de reprise. Les entreprises profiteront de ce regain de croissance pour restaurer progressivement leur situation financière. Cette stratégie repose prioritairement sur l’augmentation de la productivité qui permettra de résorber les marges de capacité de production et de restaurer le taux de marge des entreprises. Le taux de chômage en France métropolitaine augmenterait légèrement pour s’établir à 10,1 % fin 2015. Il s’élèverait à 10,5 % pour la France entière. La contrepartie à l’allègement de la rigueur est un déficit public plus élevé que ce qui avait été initialement programmé. Celui-ci devrait s’établir à 3,7 % du PIB en 2014 et 3 % en 2015.
Antibody-Opsonized Bacteria Evoke an Inflammatory Dendritic Cell Phenotype and Polyfunctional Th Cells by Cross-Talk between TLRs and FcRs
Authors: Bakema Jantine E. , Tuk Cornelis W. , van Vliet Sandra J. , Bruijns Sven C. , Vos Joost B. , Letsiou Sophia , Dijkstra Christien D. , van Kooyk Yvette , Brenkman Arjan B. , van Egmond Marjolein 
Published: January 2015

Abstract
During secondary immune responses, Ab-opsonized bacteria are efficiently taken up via FcRs by dendritic cells. We now demonstrate that this process induces cross-talk between FcRs and TLRs, which results in synergistic release of several inflammatory cytokines, as well as altered lipid metabolite profiles. This altered inflammatory profile redirects Th1 polarization toward Th17 cell responses. Interestingly, GM-CSF–producing Th cells were synergistically evoked as well, which suggests the onset of polyfunctional Th17 cells. Synergistic cytokine release was dependent on activation via MyD88 and ITAM signaling pathways through TLRs and FcRs, respectively. Cytokine regulation occurred via transcription-dependent mechanisms for TNF-α and IL-23 and posttranscriptional mechanisms for caspase-1–dependent release of IL-1β. Furthermore, cross-talk between TLRs and FcRs was not restricted to dendritic cells. In conclusion, our results support that bacteria alone initiate fundamentally different immune responses compared with Ab-opsonized bacteria through the combined action of two classes of receptors and, ultimately, may refine new therapies for inflammatory diseases.
Acquisition of Activation Receptor Ligand by Trogocytosis Renders NK Cells Hyporesponsive
Authors: Miner Cathrine A. , Giri Tusar K. , Meyer Claire E. , Shabsovich Mark , Tripathy Sandeep K. 
Published: January 2015

Abstract
Because NK cells secrete cytotoxic granules and cytokines that can destroy surrounding cells and help shape the subsequent immune response, they must be kept under tight control. Several mechanisms, at different levels, are in place to control NK cell function. In this study, we describe a novel mechanism regulating NK cell function in which NK cells acquire ligands for activating receptors from target cells by trogocytosis, rendering the NK cells hyporesponsive. In this model, murine NK cells acquire m157, the murine CMV–encoded ligand for the Ly49H-activating receptor, from target cells both in vitro and in vivo. Although acquisition of m157 requires cell-to-cell contact, it does not require the expression of the Ly49H receptor by the NK cell. Acquired m157 protein is expressed on the NK cell surface with a glycosylphosphatidylinisotol linkage and interacts with the Ly49H receptor expressed on the NK cell. This interaction results in blocking the Ly49H receptor that prevents the NK cells from recognizing m157-expressing targets and continuous engagement of the Ly49H-activating receptor, which results in the hyporesponsiveness of the Ly49H+ NK cell to stimulation through other activating receptors. Thus, NK cell acquisition of a ligand for an activation receptor by trogocytosis renders them hyporesponsive. This mechanism, by which mature NK cell function can be altered, has important implications in regard to how NK cells respond to tumors in specific microenvironments as well as the use of expanded NK cells in treating various malignancies.