bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flood hazard mapping using GIS‐based AHP approach for Krishna River basin
Authors: Vashist Komal , Singh Krishna Kumar 
Published: June 2024

AbstractFlood hazard mapping is an essential tool for determining the risk and susceptibility of flood‐prone locations. This constitutes various criteria and factors that require a methodical and comprehensive decision‐making framework. The analytic hierarchy process (AHP), the popular multi‐criterion decision‐making (MCDM) technique, which deals with the complicated problems, including qualitative and quantitative factor, is utilized in this study for developing flood hazard maps in integration with geographic information system (GIS). Flood hazard maps are developed for the Krishna River basin using AHP‐GIS. Digital elevation model, rainfall data, soil data and Landsat images are used to extract the various hazard indicators. Nine hazard indicators are employed in this study to prepare the thematic layers, which includes Topographical Wetness Index, elevation, slope rainfall, LULC, Normalized Difference Wetness Index, distance from river, soil type and drainage density. The thematic layers are combined in Arc GIS using weighted overlay method to prepare the flood hazard zonation maps. The hazard maps are classified in three categories as low, moderate and high hazard zones. For the Krishna River basin, 30 percent area was found in high hazard. The outcomes derived from the AHP‐GIS method are validated by comparing them with situational reports pertinent to the area, showcasing a robust agreement with the available dataset.
Banking market consolidation in Asia: Evidence from acquirers, targets, and rivals
Authors: Kolaric Sascha , Kiesel Florian , Schiereck Dirk 
Published: June 2024

AbstractWe analyse the financial sector consolidation in Asia by using a comprehensive sample of bank M&As from 1995 to 2021. Our results show that M&A announcements by Asian domestic acquirers are associated with significant positive stock price returns to both acquirers and their rivals. In contrast, cross‐border acquirers and their rivals experience negative but insignificant returns, while targets and their rivals record gains, regardless whether it is a domestic or cross‐border transaction. Further analyses reveal that domestic acquirers obtaining larger relative increases in their market share benefit the most, indicating that market power considerations are the primary driver behind acquirers' positive returns. For cross‐border acquirers, neither cultural differences nor regulatory arbitrage considerations can explain return patterns surrounding M&A announcements.
Stage distribution and prognostic accuracy of the 2023 FIGO (the International Federation of Gynecology & Obstetrics) staging system for endometrial cancer: A retrospective cohort study
Authors: Loukovaara Mikko , Pasanen Annukka , Bützow Ralf 
Published: June 2024

AbstractObjectiveTo assess the stage distribution and stage‐related disease‐specific survival rates for endometrial cancer using the FIGO (the International Federation of Gynecology & Obstetrics) 2009 and 2023 staging systems. Further, we sought to evaluate the prognostic utility of additional covariates beyond the FIGO 2023 stage.MethodsEndometrial carcinomas were molecularly classified by the Proactive Molecular Risk Classifier for Endometrial Cancer and staged according to FIGO 2009 and 2023 criteria. Disease‐specific survival was calculated as the time from surgery to death from endometrial cancer.ResultsData from 604 patients were analyzed. Median follow‐up time was 81 months. A total of 118 stage shifts (19.5%) occurred between the FIGO 2009 and FIGO 2023 systems, with upshifts accounting for 107 (90.7%) of these changes. Within the FIGO 2023 system, molecular classification resulted in restaging of 69 patients (11.4%). Shifts that could alter adjuvant therapy decisions were identified in 23 patients (3.8%). The FIGO 2023 system effectively categorized endometrial cancers into prognostic subgroups. The FIGO 2023 stage, tumor size, positive peritoneal cytology, and mismatch repair deficiency were associated with disease‐specific survival in a multivariable analysis, whereas age and adjuvant therapy were not.ConclusionThe FIGO 2023 staging system for endometrial cancer appears highly prognostic. Prognostic assessment of the patients can be further enhanced by readily accessible covariates. A stage shift between the FIGO 2009 and 2023 systems occurs in about one‐fifth of patients. The implementation of molecular classification within the FIGO 2023 system bears implications for decisions regarding adjuvant therapy.
Abstinence beliefs in early adolescence and sexual risk behavior two years later
Authors: Bhochhibhoya Shristi , Edison Briana , Baumler Elizabeth R. , Markham Christine M. , Emery Susan T. , Peskin Melissa F. , Shegog Ross , Addy Robert C. , Temple Jeff R. , Reidy Dennis E. 
Published: June 2024

AbstractIntroductionThe United States has the highest teen pregnancy rate and sexually transmitted infection rates among developed countries. One common approach that has been implemented to reduce these rates is abstinence‐only‐until‐marriage programs that advocate for delaying sexual intercourse until marriage. These programs focus on changing adolescents' beliefs toward abstinence until marriage; however, it is unclear whether adolescents' beliefs about abstinence predict their sexual behavior, including sexual risk behavior (SRB). An alternative approach may be encouraging youth to delay their sexual debut until they reach the age of maturity, but not necessarily until marriage.MethodsTo address this question, we compare the longitudinal association between abstinence beliefs (i.e., abstaining completely until marriage) and beliefs about delayed sexual debut with subsequent SRB 24 months later. The harmonized data set included 4620 (58.2% female, Mage = 13.0, SDage = 0.93) participants from three randomized controlled trials attending 44 schools in the southern United States. Negative binomial regressions were employed to examine the association of abstinence until marriage beliefs and beliefs regarding delaying sex with SRB.ResultsWe identified that beliefs supporting delaying sex until an age of maturity were associated with lower odds of engaging in SRB, such as having multiple sex partners and frequency of condomless sex, for both sexes. However, stronger abstinence beliefs had no significant associations with all SRB outcomes.ConclusionsFindings suggest prevention programming that focuses on encouraging youth to delay sex until an appropriate age of maturity may be more effective at preventing SRB and consequent negative sexual health outcomes.
Longitudinal associations among basic psychological need satisfaction at school, self‐esteem, and suicidal ideation from middle childhood to early adolescence: Disentangling between‑ and within‑person associations
Authors: Yang Chi , Huebner E. Scott , Tian Lili 
Published: June 2024

AbstractIntroductionThe current study aimed to examine the longitudinal associations among basic psychological need satisfaction at school (BPNSS), self‐esteem, and suicidal ideation (SI), including whether self‐esteem functioned as a mediator of the relations between BPNSS and SI at the within‐person level after disentangling between‐ and within‐person associations encompassing middle childhood to early adolescence.MethodsA total of 650 Chinese students (53.54% boys, Mage = 9.95, SD = 0.75 at Time 1) completed measures on four occasions across 1.5 years, using 6‐month intervals. Random intercept cross‐lagged panel models were applied to disaggregate between‐ and within‐person effects, thus providing greater confidence in elucidating the causal relations among study variables.ResultsThe results showed that at the within‐person level: (a) BPNSS negatively predicted SI; (b) BPNSS positively predicted self‐esteem; (c) Self‐esteem negatively predicted SI; and (d) BPNSS indirectly predicted SI via self‐esteem.ConclusionThese findings advanced the literature by demonstrating longitudinal associations among BPNSS, self‐esteem, and SI at the within‐person level, and highlighting the significance of distinguishing between‐ and within‐person effects in developing prevention and intervention programs aimed at reducing SI over time from middle childhood to early adolescence.
Immunogenicity of SARS‐CoV‐2 vaccines in patients treated with chronic double filtration plasmapheresis
Authors: Pambrun Emilie , Loubet Paul , Fourneron Thomas , Moranne Olivier 
Published: June 2024

AbstractBackgroundThe impact of chronic therapeutic plasmapheresis on humoral response following COVID‐19 vaccination is poorly documented, especially among patients treated with double filtration plasmapheresis (DFPP).ObjectivesThis retrospective single‐center study evaluated the humoral response after SARS‐CoV‐2 vaccination and studied anti‐SPIKE seropositivity and antibody dynamics in patients with chronic DFPP at our institution.MethodAll patients undergoing chronic DFPP at a tertiary center in France from December 2020 to November 2022 were included. We defined one patient subgroup as Group 1 to evaluate anti‐SPIKE seropositivity after vaccination, with three groups based on their anti‐SPIKE titers: (Group 1A) nonresponders (<0.8 UI/mL), (Group 1B) weak responders (0.8 to <250 binding antibody unit [BAU]/mL), and (Group 1C) strong responders (>250 BAU/mL). Group 2 served to evaluate antibody dynamics with anti‐SPIKE levels measured 3 months after initial vaccination, Group 2A having a sustained level and Group 2B a declining pattern.ResultsThe 21 patients included had a median age of 63 years, and 13 (56%) were male. The indications for chronic DFPP mainly included dysimmune pathologies (15; 71%) and familial dyslipidemia (6; 29%). For the humoral response to vaccination in Patient Group 1, the only nonresponder was a patient who had undergone kidney transplantation 30 months earlier and was on immunosuppressive medication. For Patient Group 2, the median follow‐up of antibody titers was 13 months [12–13]. Two distinct patterns of anti‐SPIKE dynamics were observed: a rapid decline in anti‐SPIKE antibody titers within 6 months following the initial vaccination or booster dose (n = 10 [71.4%] Group 2A) and stable anti‐SPIKE levels above 250 BAU/mL over >6 months (n = 4 [28.6%] Group 2B) with more patients with familial dyslipidemia in the former.ConclusionsHumoral response to SARS‐CoV‐2 vaccination appears robust in patients undergoing chronic DFPP and may be linked to patients' immune status rather than DFPTP itself. Our results support current recommendations for administering three doses of vaccine with a booster every 6 months.
Structural characteristics and regenerative potential: Insights from the molly fish spinal cord
Authors: Awad Mahmoud , Sayed Ramy K. A. , Mohammadin Dalia , Hussein Marwa M. , Mokhtar Doaa M. 
Published: June 2024

AbstractUnlike mammals, species such as fish and amphibians can regenerate damaged spinal cords, offering insights into potential therapeutic targets. This study investigates the structural features of the molly fish spinal cord through light and electron microscopy. The most notable characteristic was the presence of Mauthner cells (M‐cells), which exhibited large cell bodies and processes, as well as synaptic connections with astrocytes. These astrocytic connections contained synaptic vesicles, suggesting electrical transmission at the M‐cell endings. Astrocytes, which were labeled with glial fibrillary acidic protein (GFAP), contained cytoplasmic glycogen granules, potentially serving as an emergency fuel source. Two types of oligodendrocytes were identified: a small, dark cell and a larger, lighter cell, both of which reacted strongly with oligodendrocyte transcription factor 2 (Olig2). The dark oligodendrocyte resembled human oligodendrocyte precursors, while the light oligodendrocyte was similar to mature human oligodendrocytes. Additionally, proliferative neurons in the substantia grisea centralis expressed myostatin, Nrf2, and Sox9. Collectively, these findings suggest that the molly fish spinal cord has advanced structural features conducive to spinal cord regeneration and could serve as an excellent model for studying central nervous system regeneration. Further studies on the functional aspects of the molly fish spinal cord are recommended.Research Highlights
Mauthner cells (M‐cell), with their typical large cell body and processes, were the most characteristic feature in Molly fish spinal cord, where it presented synaptic connections with astrocytes and their ends contained synaptic vesicles indicating an electrical transmission in the M‐cells endings.
Two types of oligodendrocytes could be recognized; both reacted intensely with Oligodendrocyte transcription factor 2 (Olig2).
The proliferative neurons of the substantia grisea centralis expressed myostatin, Nrf2, and Sox9.
The findings of this study suggest that molly fish possess highly developed structural features conducive to spinal cord regeneration. Consequently, they could be deemed an exemplary model for investigating central nervous system regeneration.
Gastric intestinal metaplasia: Prevalence in a large Australian center and nationwide survey of endoscopic practice
Authors: Hartley Imogen , Connoley Declan , Sane Nikhita , Hirsch Ryan , Abeywickrama Dilini , Sim Nicholle , Ea Vinny , Azzopardi Robert , Simpson Ian , Bell Sally , Hew Simon 
Published: June 2024

AbstractBackground and AimAtrophic gastritis (AG) and gastric intestinal metaplasia (GIM) are early changes in the stepwise progression to gastric adenocarcinoma. There is heterogeneity in international guidelines regarding the endoscopic diagnosis and surveillance of AG and GIM. This study aims to determine the prevalence of GIM in an Australian center and assess the approach of Australian endoscopists for these two conditions.MethodsWe conducted a single‐center retrospective study of adult patients between January 2015 and December 2020 diagnosed with GIM on gastric biopsy following upper gastric endoscopy. A web‐based, 25‐question, investigator‐designed, multiple‐choice survey was distributed among all registered endoscopists in Australia.ResultsThe overall prevalence of GIM within a single Australian center was 11.7% over 5 years. Of the 1026 patients identified, only 58.7% underwent mapping biopsies using the modified Sydney protocol. Among the cohort, 1.6% had low‐grade dysplasia, 0.9% had high‐grade dysplasia, and 1.8% had malignancy on initial gastroscopy. Two hundred and sixty‐seven (7.2%) endoscopists completed the survey, 44.2% indicated they would perform mapping for all patients, and 36% only for high‐risk patients. Only 1.5% (n = 4) of respondents were able to correctly identify all six endoscopic photos of GIM/AG.ConclusionThis study demonstrates that in a large tertiary center, GIM is a prevalent endoscopic finding, but the associated rates of dysplasia and cancer were low. Additionally, among a small proportion of surveyed Australian endoscopists, there is notable variability in the endoscopic approach for AG and GIM and significant knowledge gaps. More training is required to increase the recognition of GIM and compliance with histological mapping.
Parenteral versus enteral fluids for infants hospitalized with bronchiolitis: The PREFER shared decision‐making prospective observational study protocol
Authors: Gill Peter J. , Buchanan Francine , Fahim Christine , Borkhoff Cornelia M. , Raza Shamama , Buba Melanie , Wahi Gita , Bayliss Ann , Zhou Kim , Kanani Ronik , Sakran Mahmoud , De Castris‐Garcia Kim , Barrowman Nicholas , Klassen Terry , Schuh Suzanne , Hulst Jessie , Straus Sharon , Macarthur Colin , Sozer Aubrey , Elwyn Glyn , Breen‐Reid Karen , Mahant Sanjay ,   The Canadian Pediatric Inpatient Research Network (PIRN)
Published: June 2024

AbstractIntroductionIncorporating shared decision‐making (SDM) with children and families in hospitals was a top priority identified by patients, caregivers, and clinicians. Bronchiolitis, a common and costly reason for hospitalization in children, is an exemplar condition to study SDM in hospitals. Internationally, clinical practice guidelines differ when recommending intravenous (IV or parenteral) or nasogastric (NG or enteral) fluids for hospitalized infants with bronchiolitis who are unsafe to be fed orally. While evidence indicates that either IV or NG fluids are safe and effective, parent involvement in SDM in selecting IV or NG fluids is unknown. Our aim is to generate knowledge of SDM with parents in choosing between IV or NG fluids and the benefits and harms of these two treatment options for hospitalized children with bronchiolitis.MethodThis is a multicenter, prospective, observational study, including children aged <12 months admitted to hospital with bronchiolitis requiring supplemental IV or NG fluids. The primary outcome will evaluate the extent of SDM in choosing IV versus NG fluids using the validated CollaboRATE tool. Secondary outcomes include the proportion of parents provided a choice of IV versus NG fluids; parent knowledge of fluid therapy; rate of fluids; length of hospital stay; and complications.DiscussionThis study will evaluate the extent of SDM in hospitalized infants with bronchiolitis who require IV or NG fluids and will evaluate both patient‐centered and clinical outcomes that are relevant to clinical practice.
Rechallenge and retreatment with topical imiquimod 5% in transplant recipients: A multicenter experience on actinic keratoses and basal cell carcinomas
Authors: Fava Paolo , Roccuzzo Gabriele , Macagno Nicole , Cavallo Francesco , Celoria Valentina , Avallone Gianluca , Zavattaro Elisa , Veronese Federica , Biancone Luigi , Savoia Paola , Quaglino Pietro 
Published: June 2024

AbstractBackgroundSolid organ transplant recipients (SOTRs) have an increased risk of developing non melanoma skin cancers (NMSCs). The use of Imiquimod, a toll‐like‐receptor agonist, is still debated in SOTRs.ObjectivesThe aim of this study was to evaluate efficacy and safety of topical Imiquimod in two Dermatology Centres for skin cancers in SOTRs.MethodsAll SOTRs with age > 18 and a dermoscopic diagnosis of superficial basal cell carcinoma (BCC) and/or actinic keratose (AK), annually followed up between January 2022 and December 2022 were screened.Results80 NMSCs (41 BCC and 39 AK) in 66 SOTRs were identified and treated.57 (86.4%) were male. The mean age was 66.2 years (30−85). 60 patients (90.1%) had transplanted kidney, 1 (1.5%) lung, 3 (4.5%) liver, and 1 (1.5%) heart.The average time since first transplant was 17 years (3−40 years). Tacrolimus, steroids, and mycophenolate mofetil were the most frequently used immunosuppressants (71%; 67.7%; 53.2% of cases, respectively).Responses to the first course of treatment were CR in 64.3% of cases (53.6% in AK; 67.7% in BCC); PR in 28.6% of cases (42.9% in AK; 12.9% in BCC); NR in 12.5% of cases (3.6% in AK; 19.4% in BCC). Fourteen patients received a second course of imiquimod for a persistent lesion (1 AK, 4 BCC) or a new lesion (4 AK, 5 BCC).Responses to the second course of treatment were observed in 4 (80%) and 7 (78%) cases in the persistent and new lesion, respectively (p = 0.34).No systemic adverse events were noted. The main side effects were mild: erythema, scales, and crusts, itching, or pain.ConclusionsTopical imiquimod represents a viable and safe option in this category of patients.The response to imiquimod in subjects who have had more than one cycle is not related to the response to previous treatments but rather to the intrinsic characteristics of the lesion.
Identification of southern Taiwan genetic variants in thyroid dyshormonogenesis through whole‐exome sequencing
Authors: Tsai Ching‐Chao , Chang Yu‐Ming , Chou Yen‐Yin , Chen Shou‐Yen , Pan Yu‐Wen , Tsai Meng‐Che 
Published: June 2024

AbstractThyroid dyshormonogenesis (TDH) is responsible for 15%–25% of congenital hypothyroidism (CH) cases. Pathogenetic variants of this common inherited endocrine disorders vary geographically. Unraveling the genetic underpinnings of TDH is essential for genetic counseling and precise therapeutic strategies. This study aims to identify genetic variants associated with TDH in Southern Taiwan using whole exome sequencing (WES). We included CH patients diagnosed through newborn screening at a tertiary medical center from 2011 to 2022. Permanent TDH was determined based on imaging evidence of bilateral thyroid structure and the requirement for continuous medication beyond 3 years of age. Genomic DNA extracted from blood was used for exome library construction, and pathogenic variants were detected using an in‐house algorithm. Of the 876 CH patients reviewed, 121 were classified as permanent, with 47 (40%) confirmed as TDH. WES was conducted for 45 patients, and causative variants were identified in 32 patients (71.1%), including DUOX2 (15 cases), TG (8 cases), TSHR (7 cases), TPO (5 cases), and DUOXA2 (1 case). Recurrent variants included DUOX2 c.3329G>A, TSHR c.1349G>A, TG c.1348delT, and TPO c.2268dupT. We identified four novel variants based on genotype, including TSHR c.1135C>T, TSHR c.1349G>C, TG c.2461delA, and TG c.2459T>A. This study underscores the efficacy of WES in providing definitive molecular diagnoses for TDH. Molecular diagnoses are instrumental in genetic counseling, formulating treatment, and developing management strategies. Future research integrating larger population cohorts is vital to further elucidate the genetic landscape of TDH.
Synthesis of recent research and attributes of recovered lean Lake Trout populations in Lake Superior, 1993–2022
Authors: Sitar Shawn P. , Seider Michael J. , Ebener Mark P. , Chong Stephen C. , Goldsworthy Cory A. , Harding Ian , Michaels S. Ben , Moore Seth A. , Pratt Thomas , Ray Bradley A. 
Published: June 2024

Abstract

Objective
This purpose of this paper is to describe the characteristics of recovered Lake Trout Salvelinus namaycush populations in Lake Superior by describing its population dynamics, ecology, and recent research and management activities since 1993, when Lake Trout were declared rehabilitated.

Methods
Data from commercial fisheries, recreational fisheries, agency stocking reports, and natural resource agency fishery-independent survey data along with published research findings on lean Lake Trout in Lake Superior between 1993 and 2022 were synthesized and reported.

Result
Currently, Lake Trout populations are self-sustaining and lightly exploited with only a few areas with elevated total mortality rates. The total annual mortality has been far below the target maximum range of 42–45%. Furthermore, stocking of hatchery Lake Trout is no longer necessary.

Conclusion
We have learned from research and management experience that the regulatory role of Lake Trout in the Great Lakes is critical to proper ecosystem function. Thus, continued commitment from natural resource agencies to cooperate and implement effective management actions is required to preserve the accomplishments of lakewide recovery of Lake Trout populations.