bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebral Amyloid Angiopathy Increases Susceptibility to Infarction After Focal Cerebral Ischemia in Tg2576 Mice
Authors: Milner Eric , Zhou Meng-Liang , Johnson Andrew W. , Vellimana Ananth K. , Greenberg Jacob K. , Holtzman David M. , Han Byung Hee , Zipfel Gregory J. 
Published: September 2014

Background and Purpose—
We and others have shown that soluble amyloid β-peptide (Aβ) and cerebral amyloid angiopathy (CAA) cause significant cerebrovascular dysfunction in mutant amyloid precursor protein (APP) mice, and that these deficits are greater in aged APP mice having CAA compared with young APP mice lacking CAA. Amyloid β-peptide in young APP mice also increases infarction after focal cerebral ischemia, but the impact of CAA on ischemic brain injury is unknown.

Methods—
To determine this, we assessed cerebrovascular reactivity, cerebral blood flow (CBF), and extent of infarction and neurological deficits after transient middle cerebral artery occlusion in aged APP mice having extensive CAA versus young APP mice lacking CAA (and aged-matched littermate controls).

Results—
We found that aged APP mice have more severe cerebrovascular dysfunction that is CAA dependent, have greater CBF compromise during and immediately after middle cerebral artery occlusion, and develop larger infarctions after middle cerebral artery occlusion.

Conclusions—
These data indicate CAA induces a more severe form of cerebrovascular dysfunction than amyloid β-peptide alone, leading to intra- and postischemic CBF deficits that ultimately exacerbate cerebral infarction. Our results shed mechanistic light on human studies identifying CAA as an independent risk factor for ischemic brain injury.
Impaired Glymphatic Perfusion After Strokes Revealed by Contrast-Enhanced MRI
Authors: Gaberel Thomas , Gakuba Clement , Goulay Romain , De Lizarrondo Sara Martinez , Hanouz Jean-Luc , Emery Evelyne , Touze Emmanuel , Vivien Denis , Gauberti Maxime 
Published: September 2014

Background and Purpose—
The aim of the present study was to investigate the impact of different stroke subtypes on the glymphatic system using MRI.

Methods—
We first improved and characterized an in vivo protocol to measure the perfusion of the glymphatic system using MRI after minimally invasive injection of a gadolinium chelate within the cisterna magna. Then, the integrity of the glymphatic system was evaluated in 4 stroke models in mice including subarachnoid hemorrhage (SAH), intracerebral hemorrhage, carotid ligature, and embolic ischemic stroke.

Results—
We were able to reliably evaluate the glymphatic system function using MRI. Moreover, we provided evidence that the glymphatic system was severely impaired after SAH and in the acute phase of ischemic stroke, but was not altered after carotid ligature or in case of intracerebral hemorrhage. Notably, this alteration in glymphatic perfusion reduced brain clearance rate of low-molecular-weight compounds. Interestingly, glymphatic perfusion after SAH can be improved by intracerebroventricular injection of tissue-type plasminogen activator. Moreover, spontaneous arterial recanalization was associated with restoration of the glymphatic function after embolic ischemic stroke.

Conclusions—
SAH and acute ischemic stroke significantly impair the glymphatic system perfusion. In these contexts, injection of tissue-type plasminogen activator either intracerebroventricularly to clear perivascular spaces (for SAH) or intravenously to restore arterial patency (for ischemic stroke) may improve glymphatic function.
Description of Aphelenchoides rotundicaudatus n. sp. (Nematoda: Aphelenchoididae) found in packaging wood from South Korea
Authors: Fang Yiwu , Wang Xuan , Gu Jianfeng , Li Hongmei 
Published: September 2014

Aphelenchoides rotundicaudatus n. sp. was isolated from packaging wood from South Korea imported to Ningbo harbour, China. Specimens were collected directly from wood samples using the Baermann method. Multiplication on Botryotinia fuckeliana failed. The new species has a body length of 364-509 μm (males) and 371-493 μm (females). The cuticle is weakly annulated and there are four lines in the lateral field. The stylet is 8-9 μm long and has small basal swellings. The excretory pore is located ca one body diam. anterior to median bulb. Spicules are small (10-13 μm), apex and rostrum rounded and only slight offset. The male tail has six (2 + 2 + 2) caudal papillae. Both male and female tails are cylindrical with a broadly rounded terminus, often with a small region of thickened cuticle or a blunt peg ca 1 μm long, particularly in the female. The new species belongs to the Group 1 category of Aphelenchoides species. Phylogenetic analyses based on full length ITS, partial LSU and SSU of rDNA confirmed its status as a new species.
Rapid Refresh Information of Significant Events: Preparing Users for the Next Generation of Geostationary Operational Satellites
Authors: Schmit Timothy J. , Goodman Steven J. , Gunshor Mathew M. , Sieglaff Justin , Heidinger Andrew K. , Bachmeier A. Scott , Lindstrom Scott S. , Terborg Amanda , Feltz Joleen , Bah Kaba , Rudlosky Scott , Lindsey Daniel T. , Rabin Robert M. , Schmidt Christopher C. 
Published: September 2014

Abstract
The Geostationary Operational Environmental Satellite-14 (GOES-14) imager was operated by the National Oceanic and Atmospheric Administration (NOAA) in an experimental rapid scan 1-min mode during parts of the summers of 2012 and 2013. This scan mode, known as the super rapid scan operations for GOES-R (SRSOR), emulates the high-temporal-resolution sampling of the mesoscale region scanning of the Advanced Baseline Imager (ABI) on the next-generation GOES-R series. This paper both introduces these unique datasets and highlights future satellite imager capabilities. Many phenomena were observed from GOES-14, including fog, clouds, severe storms, fires and smoke (including the California Rim Fire), and several tropical cyclones. In 2012 over 6 days of SRSOR data of Hurricane Sandy were acquired. In 2013, the first two days of SRSOR in June observed the propagation and evolution of a mid-Atlantic derecho. The data from August 2013 were unique in that the GOES imager operated in nearly continuous 1-min mode; prior to this time, the 1-min data were interrupted every 3 h for full disk scans. Used in a number of NOAA test beds and operational centers, including NOAA’s Storm Prediction Center (SPC), the Aviation Weather Center (AWC), the Ocean Prediction Center (OPC), and the National Hurricane Center (NHC), these experimental data prepare users for the next-generation imager, which will be able to routinely acquire mesoscale (1,000 km × 1,000 km) images every 30 s (or two separate locations every minute). Several animations are included, showcasing the rapid change of the many phenomena observed during SRSOR from the GOES-14 imager.
On the Characteristics of and Processes Producing Winter Precipitation Types near 0°C
Authors: Stewart Ronald E. , Thériault Julie M. , Henson William 
Published: September 2014

Abstract
This article examines the types of winter precipitation that occur near 0°C, specifically rain, freezing rain, freezing drizzle, ice pellets, snow pellets, and wet snow. It follows from a call by M. Ralph et al. for more attention to be paid to this precipitation since it represents one of the most serious wintertime quantitative precipitation forecasting (QPF) issues. The formation of the many precipitation types involves ice-phase and/or liquid-phase processes, and thresholds in the degree of melting and/or freezing often dictate the types occurring at the surface. Some types can occur simultaneously so that, for example, ensuing collisions between supercooled raindrops and ice pellets that form ice pellet aggregates can lead to substantial reductions in the occurrence of freezing rain at the surface, and ice crystal multiplication processes can lead to locally produced ice crystals in the subfreezing layer below inversions. Highly variable fall velocities within the background temperature and wind fields of precipitation-type transition regions lead to varying particle trajectories and significant alterations in the distribution of precipitation amount and type at the surface. Physically based predictions that account for at least some of the phase changes and particle interactions are now in operation. Outstanding issues to be addressed include the impacts of accretion on precipitation-type formation, quantification of melting and freezing rates of the highly variable precipitation, the consequences of collisions between the various types, and the onset of ice nucleation and its effects. The precipitation physics perspective of this article furthermore needs to be integrated into a comprehensive understanding involving the surrounding and interacting environment.
A New Compilation of North Atlantic Tropical Cyclones, 1851–98*
Authors: Chenoweth Michael 
Published: September 2014

Abstract
A comprehensive new compilation of North Atlantic tropical cyclone activity for the years 1851–98 is presented and compared with the second-generation North Atlantic hurricane database (HURDAT2) for the same years. This new analysis is based on the retrieval of 9072 newspaper marine shipping news reports, 1260 original logbook records, 271 Maury abstract logs, 147 U.S. marine meteorological journals, and 34 Met Office (UKMO) logbooks. Records from throughout North America and the Caribbean region were used along with other primary and secondary references holding unique land and marine data. For the first time, North Atlantic daily weather maps for 1864/65, 1873, and 1881–98 were used in historical tropical cyclone research. Results for the years 1851–98 include the omission of 62 of the 361 HURDAT2 storms, and the further reduction resulting from the merging of storms to a total of 288 unique HURDAT2 tropical cyclones. The new compilation gave a total of 497 tropical cyclones in the 48-yr record, or an average of 10.4 storms per year compared to 6.0 per year in HURDAT2 less the author’s omissions. Of this total, 209 storms are completely new. A total of 90 hurricanes made landfall in the United States during this time. Seven new U.S. landfalling hurricanes are present in the new dataset but not in HURDAT2. Eight U.S. landfalling hurricanes in HURDAT2 are now considered to have only tropical storm impact or were actually extratropical at landfall. Across the North Atlantic, the number of category-4 hurricanes based on the Saffir–Simpson hurricane wind scale, compared with HURDAT2, increased from 11 to 25, 6 of which made U.S. landfall at category-4 level.
Coupled Impacts of the Diurnal Cycle of Sea Surface Temperature on the Madden–Julian Oscillation
Authors: Seo Hyodae , Subramanian Aneesh C. , Miller Arthur J. , Cavanaugh Nicholas R. 
Published: September 2014

Abstract
This study quantifies, from a systematic set of regional ocean–atmosphere coupled model simulations employing various coupling intervals, the effect of subdaily sea surface temperature (SST) variability on the onset and intensity of Madden–Julian oscillation (MJO) convection in the Indian Ocean. The primary effect of diurnal SST variation (dSST) is to raise time-mean SST and latent heat flux (LH) prior to deep convection. Diurnal SST variation also strengthens the diurnal moistening of the troposphere by collocating the diurnal peak in LH with those of SST. Both effects enhance the convection such that the total precipitation amount scales quasi-linearly with preconvection dSST and time-mean SST. A column-integrated moist static energy (MSE) budget analysis confirms the critical role of diurnal SST variability in the buildup of column MSE and the strength of MJO convection via stronger time-mean LH and diurnal moistening. Two complementary atmosphere-only simulations further elucidate the role of SST conditions in the predictive skill of MJO. The atmospheric model forced with the persistent initial SST, lacking enhanced preconvection warming and moistening, produces a weaker and delayed convection than the diurnally coupled run. The atmospheric model with prescribed daily-mean SST from the coupled run, while eliminating the delayed peak, continues to exhibit weaker convection due to the lack of strong moistening on a diurnal basis. The fact that time-evolving SST with a diurnal cycle strongly influences the onset and intensity of MJO convection is consistent with previous studies that identified an improved representation of diurnal SST as a potential source of MJO predictability.
Improved Stepped Frequency Microwave Radiometer Tropical Cyclone Surface Winds in Heavy Precipitation
Authors: Klotz Bradley W. , Uhlhorn Eric W. 
Published: September 2014

AbstractSurface wind speeds retrieved from airborne stepped frequency microwave radiometer (SFMR) brightness temperature measurements are important for estimating hurricane intensity. The SFMR performance is highly reliable at hurricane-force wind speeds, but accuracy is found to degrade at weaker wind speeds, particularly in heavy precipitation. Specifically, a significant overestimation of surface wind speeds is found in these conditions, suggesting inaccurate accounting for the impact of rain on the measured microwave brightness temperature. In this study, the wind speed bias is quantified over a broad range of operationally computed wind speeds and rain rates, based on a large sample of collocated SFMR wind retrievals and global positioning system dropwindsonde surface-adjusted wind speeds. The retrieval bias is addressed by developing a new SFMR C-band relationship between microwave absorption and rain rate (κ−R) from National Oceanic and Atmospheric Administration WP-3D aircraft tail Doppler radar reflectivity and in situ Droplet Measurement Technologies Precipitation Imaging Probe measurements to more accurately model precipitation impacts. Absorption is found to be a factor of 2 weaker than is estimated by the currently operational algorithm. With this new κ–R relationship, surface wind retrieval bias is significantly reduced in the presence of rain at wind speeds weaker than hurricane force. At wind speeds greater than hurricane force where little bias exists, no significant change is found. Furthermore, maximum rain rates computed using the revised algorithm are around 50% greater than operational measurements, which is more consistent with maximum reflectivity-estimated rain rates in hurricanes.
Meteor Trail Echo Rejection in Atmospheric Phased Array Radars Using Adaptive Sidelobe Cancellation
Authors: Hashimoto Taishi , Nishimura Koji , Tsutsumi Masaki , Sato Toru 
Published: September 2014

AbstractStrong meteor trail echoes are interferences in the wind velocity estimates made from mesosphere radar observations. Contaminated spectra are detected by their discontinuity and are removed at the risk of greater fluctuations of spectra, leading to a severe reduction of the signal-to-noise ratio (SNR) and inaccurate wind estimates for weak atmospheric echoes. This paper presents an adaptive signal processing technique for the suppression of spectral contaminations by meteor trail echoes. The method is based on the norm-constrained and directionally constrained minimization of power (NC-DCMP), which balances the capability of canceling the clutter and the robustness of beam shaping, at the cost of a slight decrease in the SNR, which can be determined in advance. Simulation results show that with a 3-dB decrease of the SNR being allowed, the method improves the signal-to-interference ratio (SIR) by 15 dB, giving wind estimates that are about 8 m s−1 better in terms of root-mean-square error and providing 4 times as wide an observable range when compared with the results of the ordinary nonadaptive beamforming method. The results for an actual observation show that the improvement of both the SIR and the observable range are achieved as in the simulations, which implies that the method should provide the simulated accuracy for the estimation of wind velocity from actual observations.
Ensemble Kalman Filtering with a Divided State-Space Strategy for Coupled Data Assimilation Problems*
Authors: Luo Xiaodong , Hoteit Ibrahim 
Published: September 2014

Abstract
This study considers the data assimilation problem in coupled systems, which consists of two components (subsystems) interacting with each other through certain coupling terms. A straightforward way to tackle the assimilation problem in such systems is to concatenate the states of the subsystems into one augmented state vector, so that a standard ensemble Kalman filter (EnKF) can be directly applied. This work presents a divided state-space estimation strategy, in which data assimilation is carried out with respect to each individual subsystem, involving quantities from the subsystem itself and correlated quantities from other coupled subsystems. On top of the divided state-space estimation strategy, the authors also consider the possibility of running the subsystems separately. Combining these two ideas, a few variants of the EnKF are derived. The introduction of these variants is mainly inspired by the current status and challenges in coupled data assimilation problems and thus might be of interest from a practical point of view. Numerical experiments with a multiscale Lorenz 96 model are conducted to evaluate the performance of these variants against that of the conventional EnKF. In addition, specific for coupled data assimilation problems, two prototypes of extensions of the presented methods are also developed in order to achieve a trade-off between efficiency and accuracy.
What Stakeholder Needs Tell Us about Enabling Adaptive Capacity: The Intersection of Context and Information Provision across Regions in the United States
Authors: Dilling Lisa , Lackstrom Kirsten , Haywood Benjamin , Dow Kirstin , Lemos Maria Carmen , Berggren John , Kalafatis Scott 
Published: September 2014

Abstract
In recent years increasing attention has been focused on understanding the different resources that can support decision makers at all levels in responding to climate variability and change. This article focuses on the role that access to information and other potential constraints may play in the context of water decision making across three U.S. regions (the Intermountain West, the Great Lakes, and the Carolinas). The authors report on the degree to which climate-related needs or constraints pertinent to water resources are regionally specific. They also find that stakeholder-identified constraints or needs extended beyond the need for data/information to enabling factors such as governance arrangements and how to improve collaboration and communication. As climate information networks expand and emphasis is placed on encouraging adaptation more broadly, these constraints have implications not only for how information dissemination efforts are organized but for how those efforts need to be informed by the larger regional context in a resource-limited and fragmented landscape.
Procalcitonin guidance for reduction of antibiotic use in patients hospitalized with severe acute exacerbations of asthma: a randomized controlled study with 12-month follow-up
Authors: Long Wei , Li Li-juan , Huang Gao-zhong , Zhang Xue-min , Zhang Yi-cui , Tang Jian-guo , Zhang Yu , Lu Gang 
Published: September 2014

Abstract
Introduction
Patients with severe acute exacerbations of asthma often receive inappropriate antibiotic treatment. We aimed to determine whether serum procalcitonin (PCT) levels can effectively and safely reduce antibiotic exposure in patients experiencing exacerbations of asthma.

Methods
In this randomized controlled trial, a total of 216 patients requiring hospitalization for severe acute exacerbations of asthma were screened for eligibility to participate and 169 completed the 12-month follow-up visit. Patients were randomized to either PCT-guided (PCT group) or standard (control group) antimicrobial therapy. In the control group, patients received antibiotics according to the attending physician’s discretion; in the PCT group, patients received antibiotics according to an algorithm based on serum PCT levels. The primary end point was antibiotic exposure; secondary end points were clinical recovery, length of hospital stay, clinical and laboratory parameters, spirometry, number of asthma exacerbations, emergency room visits, hospitalizations and need for corticosteroid use due to asthma.

Results
PCT guidance reduced antibiotic prescription (48.9% versus 87.8%, respectively; P < 0.001) and antibiotic exposure (relative risk, 0.56; 95% confidence interval, 0.44 to 0.70; P < 0.001) compared to standard therapy. There were no significant differences in clinical recovery, length of hospital stay or clinical, laboratory and spirometry outcomes in both groups. Number of asthma exacerbations, emergency room visits, hospitalizations and need for corticosteroid use due to asthma were similar during the 12-month follow-up period.

Conclusion
A PCT-guided strategy allows antibiotic exposure to be reduced in patients with severe acute exacerbation of asthma without apparent harm.

Trial registration
Chinese Clinical Trial Register ChiCTR-TRC-12002534 (registered 26 September 2012)
Heparin-like effect in postcardiotomy extracorporeal membrane oxygenation patients
Authors: Ranucci Marco , Baryshnikova Ekaterina , Isgrò Giuseppe , Carlucci Concetta , Cotza Mauro , Carboni Giovanni , Ballotta Andrea 
Published: September 2014

Abstract
Introduction
Unfractionated heparin (UFH) is the anticoagulant of choice for extracorporeal membrane oxygenation (ECMO), but bivalirudin can be used as an alternative. The purpose of the present study is to investigate the existence of a heparin-like effect (HLE) during heparin-free ECMO.

Methods
This is a retrospective study on patients treated with ECMO and receiving bivalirudin as the sole anticoagulant. Thromboelastography (TEG) tests with and without heparinase were recorded during the ECMO duration. A total of 41 patients (22 pediatrics and 19 adults) treated with ECMO after cardiac surgery procedures and receiving only bivalirudin-based anticoagulation were studied. Based on the presence of a different reaction time (R-time) between the TEG test with heparinase or without heparinase we defined the presence of a HLE. Survival to hospital discharge, liver failure, sepsis, bleeding and transfusion rate were analyzed for association with HLE with univariate tests.

Results
HLE was detected in 56.1% of the patients. R-times were significantly shorter in tests done with heparinase versus without heparinase during the first seven days on ECMO. Patients with HLE had a significantly (P = 0.046) higher rate of sepsis (30%) than patients without HLE (5.6%) at a Pearson's chi-square test.

Conclusions
A heparin-like effect is common during ECMO, and most likely due to a release of heparinoids from the glycocalyx and the mast cells, as a consequence of sepsis or of the systemic inflammatory reaction triggered by the contact of blood with foreign surfaces.