bluuebunny/crossref_metadata_2025_split huggingface dataset:
An intestinal TH17 cell-derived subset can initiate cancer
Authors: Fesneau Olivier , Thevin Valentin , Pinet Valérie , Goldsmith Chloe , Vieille Baptiste , M’Homa Soudja Saïdi , Lattanzio Rossano , Hahne Michael , Dardalhon Valérie , Hernandez-Vargas Hector , Benech Nicolas , Marie Julien C. 
Published: July 2024

AbstractApproximately 25% of cancers are preceded by chronic inflammation that occurs at the site of tumor development. However, whether this multifactorial oncogenic process, which commonly occurs in the intestines, can be initiated by a specific immune cell population is unclear. Here, we show that an intestinal T cell subset, derived from interleukin-17 (IL-17)-producing helper T (TH17) cells, induces the spontaneous transformation of the intestinal epithelium. This subset produces inflammatory cytokines, and its tumorigenic potential is not dependent on IL-17 production but on the transcription factors KLF6 and T-BET and interferon-γ. The development of this cell type is inhibited by transforming growth factor-β1 (TGFβ1) produced by intestinal epithelial cells. TGFβ signaling acts on the pretumorigenic TH17 cell subset, preventing its progression to the tumorigenic stage by inhibiting KLF6-dependent T-BET expression. This study therefore identifies an intestinal T cell subset initiating cancer.
Vitrectomy versus scleral buckle for retinal detachment without posterior vitreous detachment
Authors: Dimakopoulou Ioanna , Mylonas Georgios , Iby Johannes , Sedova Alexandra , Hollaus Marlene , Sacu Stefan , Georgopoulos Michael , Schmidt-Erfurth Ursula 
Published: July 2024

AbstractTo compare the effectiveness and safety of scleral buckling and pars plana vitrectomy in treating retinal detachment without posterior vitreous detachment. A total of 88 eyes of 83 patients with retinal detachment without prior posterior vitreous detachment were investigated retrospectively. Group A comprised patients who underwent scleral buckling (n = 47) and Group B (n = 36) patients who were treated with pars plana vitrectomy. Anatomical success, postoperative visual acuity, and ocular adverse events were evaluated. The primary and final anatomical success rate showed a nonsignificant difference (p = 0.465 and p = 0.37 respectively). No significant difference was observed in the reoperation rate or development of epiretinal membrane between the groups (p = 0.254 and p = 0.254 respectively). However, scleral buckling resulted in significantly better visual acuity at the last follow-up (0.12 ± 0.23) compared to pars plana vitrectomy (0.37 ± 0.46, p = 0.001). The incidence of cataract progression was also significantly higher in the pars plana vitrectomy group (46%) compared to the scleral buckling group (10%, p < 0.001). Scleral buckling and pars plana vitrectomy show similar success rates in treating retinal detachment without vitreous detachment. However, due to less cataract progression and better visual acuity outcomes, scleral buckling is recommended for these cases. Determining vitreous status before surgery is crucial for optimal outcomes.
A novel ECG compression algorithm using Pulse-Width Modulation integrated quantization for low-power real-time monitoring
Authors: Devindi Isuri , Liyanage Sashini , Jayarathna Titus , Alawatugoda Janaka , Ragel Roshan 
Published: July 2024

AbstractCardiac monitoring systems in Internet of Things (IoT) healthcare, reliant on limited battery and computational capacity, need efficient local processing and wireless transmission for comprehensive analysis. Due to the power-intensive wireless transmission in IoT devices, ECG signal compression is essential to minimize data transfer. This paper presents a real-time, low-complexity algorithm for compressing electrocardiogram (ECG) signals. The algorithm uses just nine arithmetic operations per ECG sample point, generating a hybrid Pulse Width Modulation (PWM) signal storable in a compact 4-bit resolution format. Despite its simplicity, it performs comparably to existing methods in terms of Percentage Root-Mean-Square Difference (PRD) and space-saving while significantly reducing complexity and maintaining robustness against signal noise. It achieves an average Bit Compression Ratio (BCR) of 4 and space savings of 90.4% for ECG signals in the MIT-BIH database, with a PRD of 0.33% and a Quality Score (QS) of 12. The reconstructed signal shows no adverse effects on QRS complex detection and heart rate variability, preserving both the signal amplitude and periodicity. This efficient method for transferring ECG data from wearable devices enables real-time cardiac activity monitoring with reduced data storage requirements. Its versatility suggests potential broader applications, extending to compression of various signal types beyond ECG.
In vivo monitoring of active subretinal fibrosis in mice using collagen hybridizing peptides
Authors: Linder Markus , Bennink Lucas , Foxton Richard H. , Kirkness Mike , Westenskow Peter D. 
Published: July 2024

AbstractSubretinal fibrosis is associated with worse visual outcomes in patients with neovascular age-related macular degeneration. As there is a lack of optimal biomarkers and no method that directly detects collagen in the back of the eye, novel tools that monitor fibrosis-related changes in neovascular age-related macular degeneration are needed. Here, using two mouse models (the laser-induced choroidal neovascularization model, and the JR5558 mouse presenting with spontaneous subretinal neovascularization with fibrosis), we imaged active fibrotic lesions using fluorescently labeled collagen hybridizing peptides (CHPs), short peptides that bind to single α-chain collagen structures during collagen remodeling. JR5558 retinal pigment epithelium/choroid flat mounts showed CHP co-staining with fibrosis and epithelial mesenchymal transition-related markers; additionally, CHP histopathology staining correlated with in vivo CHP imaging. After laser-induced choroidal neovascularization, in vivo CHP binding correlated with laser intensity, histopathology CHP and fibronectin staining. Laser-induced choroidal neovascularization showed decreased CHP intensity over time in healing/regressing versus active scars in vivo, whereas increased CHP binding correlated with elevated fibrosis in JR5558 mouse eyes with age. In bispecific angiopoietin 2/vascular endothelial growth factor antibody-treated JR5558 mice, CHPs detected significantly decreased collagen remodeling versus immunoglobulin G control. These results demonstrate the first use of CHPs to directly image remodeling collagen in the eye and as a potential clinical optical biomarker of active subretinal fibrosis associated with ocular neovascularization.
Combined inhibition of EZH2 and CDK4/6 perturbs endoplasmic reticulum-mitochondrial homeostasis and increases antitumor activity against glioblastoma
Authors: Freitag Thomas , Kaps Philipp , Ramtke Justus , Bertels Sarah , Zunke Emily , Schneider Björn , Becker Anne-Sophie , Koczan Dirk , Dubinski Daniel , Freiman Thomas M. , Wittig Felix , Hinz Burkhard , Westhoff Mike-Andrew , Strobel Hannah , Meiners Franziska , Wolter Daniel , Engel Nadja , Troschke-Meurer Sascha , Bergmann-Ewert Wendy , Staehlke Susanne , Wolff Annabell , Gessler Florian , Junghanss Christian , Maletzki Claudia 
Published: July 2024

AbstractHere, we show that combined use of the EZH2 inhibitor GSK126 and the CDK4/6 inhibitor abemaciclib synergistically enhances antitumoral effects in preclinical GBM models. Dual blockade led to HIF1α upregulation and CalR translocation, accompanied by massive impairment of mitochondrial function. Basal oxygen consumption rate, ATP synthesis, and maximal mitochondrial respiration decreased, confirming disrupted endoplasmic reticulum-mitochondrial homeostasis. This was paralleled by mitochondrial depolarization and upregulation of the UPR sensors PERK, ATF6α, and IRE1α. Notably, dual EZH2/CDK4/6 blockade also reduced 3D-spheroid invasion, partially inhibited tumor growth in ovo, and led to impaired viability of patient-derived organoids. Mechanistically, this was due to transcriptional changes in genes involved in mitotic aberrations/spindle assembly (Rb, PLK1, RRM2, PRC1, CENPF, TPX2), histone modification (HIST1H1B, HIST1H3G), DNA damage/replication stress events (TOP2A, ATF4), immuno-oncology (DEPDC1), EMT-counterregulation (PCDH1) and a shift in the stemness profile towards a more differentiated state. We propose a dual EZH2/CDK4/6 blockade for further investigation.
Antiferromagnetic domain wall memory with neuromorphic functionality
Authors: Godinho J. , Rout P. K. , Salikhov R. , Hellwig O. , Šobáň Z. , Otxoa R. M. , Olejník K. , Jungwirth T. , Wunderlich J. 
Published: July 2024

AbstractAntiferromagnetic materials have unique properties due to their alternating spin arrangements. Their compensated magnetic order, robust against external magnetic fields, prevents long-distance crosstalk from stray fields. Furthermore, antiferromagnets with combined parity and time-reversal symmetry enable electrical control and detection of ultrafast exchange-field enhanced spin manipulation up to THz frequencies. Here we report the experimental realization of a nonvolatile antiferromagnetic memory mimicking an artificial synapse, in which the reconfigurable synaptic weight is encoded in the ratio between reversed antiferromagnetic domains. The non-volatile memory is “written” by spin-orbit torque-driven antiferromagnetic domain wall motion and “read” by nonlinear magnetotransport. We show that the absence of long-range interacting stray magnetic fields leads to very reproducible electrical pulse-driven variations of the synaptic weights.
Germline loss in C. elegans enhances longevity by disrupting adhesion between niche and stem cells
Authors: Liu Meng , Chen Jiehui , Cui Guizhong , Dai Yumin , Song Mengjiao , Zhou Chunyu , Hu Qingyuan , Chen Qingxia , Wang Hongwei , Chen Wanli , Han Jingdong Jackie , Peng Guangdun , Jing Naihe , Shen Yidong 
Published: July 2024

AbstractAgeing and fertility are intertwined. Germline loss extends the lifespan in various organisms, termed gonadal longevity. However, the original longevity signal from the somatic gonad remains poorly understood. Here, we focused on the interaction between germline stem cells (GSCs) and their niche, the distal tip cells (DTCs), to explore the barely known longevity signal from the somatic gonad in C. elegans. We found that removing germline disrupts the cell adhesions between GSC and DTC, causing a significant transcriptomic change in DTC through hmp-2/β-catenin and two GATA transcription factors, elt-3 and pqm-1 in this niche cell. Inhibiting elt-3 and pqm-1 in DTC suppresses gonadal longevity. Moreover, we further identified the TGF-β ligand, tig-2, as the cytokine from DTC upon the loss of germline, which evokes the downstream gonadal longevity signalling throughout the body. Our findings thus reveal the source of the longevity signalling in response to germline removal, highlighting the stem cell niche as a critical signalling hub in ageing.
Morphological and Inhibitory Skills in Monolingual and Bilingual Children With and Without Developmental Language Disorder
Authors: Gandolfi Elena , Diotallevi Giovanna , Viterbori Paola 
Published: July 2024

Purpose:
This study examined the language and nonverbal inhibitory control skills of Italian monolingual and bilingual typically developing (TD) preschoolers with Italian as their second language and of age-matched monolingual and bilingual peers with developmental language disorder (DLD).

Method:
Four groups of preschoolers were enrolled: 30 TD Italian monolinguals, 24 TD bilinguals, 19 Italian monolinguals with DLD, and 19 bilinguals with DLD. All children were assessed in Italian on vocabulary, receptive morphosyntax, and morphological markers for DLD in the Italian language (i.e., third-person verb inflections, definite articles, third-person direct-object clitic pronouns, simple prepositions) and nonverbal inhibitory control skills. Group performance was compared using a series of one-way analyses of variance.

Results:
Monolingual and bilingual children with DLD achieved significantly lower performance in all language measures compared to both TD monolingual and bilingual children. However, TD bilinguals, although comprehensively showing better language skills than monolinguals with DLD, achieved a performance closer to that of monolinguals with DLD but significantly higher than that of bilinguals with DLD. Both TD monolinguals and bilinguals showed better results than both DLD groups in inhibitory control tasks, particularly in the interference suppression task.

Conclusions:
This study provides a picture of language and inhibitory control characteristics of children with various language profiles and adds to the literature on potential markers of DLD among bilingual children. These results suggest that the assessment of nonlinguistic markers, which are associated with language impairment, could be a useful approach to better specify the diagnosis of DLD and reduce cases of misdiagnosis in the context of bilingualism.
Intelligent method framework for 3D surface manufacturing in cloud‐edge collaboration architecture
Authors: Cai Hongming , Dong Yanjun , Zhu Min , Hu Pan , Hu Haoyuan , Jiang Lihong 
Published: July 2024

AbstractLarge and complex workpieces are core components in fields, such as aerospace, shipbuilding, and other industrial applications. However, the main challenge of curved plate processing comes from the difficulty in determining the nonlinear rebound features with structural design parameters. An intelligent method framework is proposed for 3D surface manufacturing in cloud‐edge collaboration environment. With the construction of an intelligent generation method for machining parameters, a unified data model is effectively integrated with various discrete data, and an intelligent processing mechanism based on 3D point clouds is constructed. In particular, a prediction method for curved panel rebound is constructed to reduce the manual dependency of the manufacturing process. Finally, a related case study is conducted to verify the framework, and the result shows accuracy, interpretability and reusability advantages over other similar methods.
VidaGAN: Adaptive GAN for image steganography
Authors: Ramandi Vida Yousefi , Fateh Mansoor , Rezvani Mohsen 
Published: July 2024

AbstractA recent approach to image steganography is to use deep learning. Mainly, convolutional neural networks can extract complex features and use them as patterns to combine hidden messages and images. Also, by using generative adversarial networks, it is possible to generate realistic and high‐quality stego images without any noticeable artifacts. Previous methods suffered from challenges such as simple architecture, low network accuracy, imbalance between capacity and transparency, vanishing gradients, and low capacity. This study introduces a steganography framework named VidaGAN that utilizes deep learning techniques. The network being proposed is made up of three components: an encoder, a decoder, and a critic, and introduces a novel architecture and several innovations to address some of the unresolved challenges mentioned above. This study introduces a novel method for embedding any type of binary data into images using generative adversarial networks, enabling us to enhance the visual appeal of images generated by the specified model. This neural network called VarIable aDAptive GAN (VidaGAN) achieved state‐of‐the‐art status by reaching a hiding capacity of 3.9 bits per pixel in the DIV2K dataset. Furthermore, examination by the StegExpose steganalysis tool shows an AUC of 0.6, a suitable threshold for transparency.
Point'n Move: Interactive scene object manipulation on Gaussian splatting radiance fields
Authors: Huang Jiajun , Yu Hongchuan , Zhang Jianjun , Nait‐Charif Hammadi 
Published: July 2024

AbstractThe authors propose Point'n Move, a method that achieves interactive scene object manipulation with exposed region inpainting. Interactivity here further comes from intuitive object selection and real‐time editing. To achieve this, Gaussian Splatting Radiance Field is adopted as the scene representation and its explicit nature and speed advantage are fully leveraged. Its explicit representation formulation allows to devise a 2D prompt points to 3D masks dual‐stage self‐prompting segmentation algorithm, perform mask refinement and merging, minimize changes, and provide good initialization for scene inpainting and perform editing in real‐time without per‐editing training; all lead to superior quality and performance. The method was tested by editing both forward‐facing and 360 scenes. The method is also compared against existing methods, showing superior quality despite being more capable and having a speed advantage.
Enhanced power system fault detection using quantum‐AI and herd immunity quantum‐AI fault detection with herd immunity optimisation in power systems
Authors: Sworna Kokila M. L. , Bibin Christopher V. , Ramya G. 
Published: July 2024

AbstractQuantum computing and deep learning have recently gained popularity across various industries, promising revolutionary advancements. The authors introduce QC‐PCSANN‐CHIO‐FD, a novel approach that enhances fault detection in electrical power systems by combining quantum computing, deep learning, and optimisation algorithms. The network, based on a Pyramidal Convolution Shuffle Attention Neural Network (PCSANN) optimised with the Coronavirus Herd Immunity Optimiser, shows promising results. Initially, historical datasets are used for fault detection. Preprocessing, which includes handling missing data and outliers using Adaptive Variational Bayesian Filtering is followed by Dual‐Domain Feature Extraction to extract grayscale statistical features. These features are processed by PCSANN to detect faults. The Coronavirus Herd Immunity Optimisation Algorithm is proposed to optimise PCSANN for precise fault detection. Performance of the proposed QC‐PCSANN‐CHIO‐FD approach attains 24.11%, 28.56% and 22.73% high specificity, 21.89%, 23.04% and 9.51% lower computation Time, 25.289%, 15.35% and 19.91% higher ROC and 8.65%, 13.8%, and 7.15% higher Accuracy compared with existing methods, such as combining deep learning based on quantum computing for electrical power system malfunction diagnosis (QC‐ANN‐FD), electrical power system fault diagnostics using hybrid quantum‐classical deep learning (QC‐CRBM‐FD), applications of machine learning to the identification of power system faults: Recent developments and future directions (QC‐RF‐FD).
Optimal frequency response coordinated control strategy for hybrid wind‐storage power plant based on state reconstruction
Authors: Tian Xinshou , Chi Yongning , Cheng Peng , Zhao Yihui , Liu Hongzhi 
Published: July 2024

AbstractWhen wind power and energy storage operate in tandem, their operational state undergoes continuous shifts during dynamic processes. Determining the frequency modulation capability of the combined wind and energy storage system during frequency modulation participation is challenging, often leading to a decline in power generation efficiency. To address this, the current study introduces an optimal frequency response coordinated control strategy for hybrid wind‐storage power plants, anchored in state reconstruction. The frequency modulation capability is restructured based on the current state of charge (SOC) of the energy storage system. Subsequently, the equivalent active power reserve demand is evaluated for wind power, leading to the formulation of a wind power reserve active power level and its corresponding operational strategy. For swift active power support, an adaptive virtual inertia control is designed for the energy storage system, contingent on its current SOC. Concurrently, an adaptive virtual inertia control for wind power is developed, grounded in effective kinetic energy. The hybrid wind‐storage power plant engages in primary frequency regulation, tailored to the nature of frequency disturbances and prevailing state characteristics. Simulation analyses affirm that this proposed strategy, which takes into account the SOC of the hybrid wind‐storage power plant and the power grid's dynamics, offers robust active power frequency support during load disturbances.
Width of the quasi-perpendicular bow shock region at Mars
Authors: Nesbit-Östman Sara , Gunell Herbert , Hamrin Maria , Opgenoorth Hermann , Andersson Laila 
Published: July 2024

Aims. We aim to quantify the width of the quasi-perpendicular Martian bow shock region to deepen the understanding of why the width is variable and which factors affect it, and to explore the implications on thermalization.
Methods. To quantify the width, 2074 quasi-perpendicular bow shock crossings from a database were studied. Upstream conditions, such as Mach numbers, dynamic pressure, ion densities, and other factors, were considered. Furthermore, the difference between the downstream and upstream temperature was measured.
Results. We found that the shock region width is correlated with the magnetosonic Mach number, the critical ratio, and the overshoot amplitude. The region was found to be anticorrelated with dynamic pressure. The width is not affected by the upstream ion density of the investigated species or by the upstream temperature. The difference between the downstream and upstream temperature is not affected by the shock region width.
Conclusions. We found that the factors that affect the stand-off distance of the bow shock, such as the magnetosonic Mach number and dynamic pressure, also affect the width. The width is also positively correlated with the overshoot amplitude, indicating that the structures are coupled or that they are affected by largely the same conditions. The lack of a correlation with the ion temperature difference indicates that the shock region width does not affect the ion thermalization.
Varying linear polarisation in the dust-free gamma-ray burst 210610B
Authors: Agüí Fernández J. F. , de Ugarte Postigo A. , Thöne C. C. , Kobayashi S. , Rossi A. , Toma K. , Jelínek M. , Kann D. A. , Covino S. , Wiersema K. , Hartmann D. , Jakobsson P. , Martin-Carrillo A. , Melandri A. , De Pasquale M. , Pugliese G. , Savaglio S. , Starling R. L. C. , Štrobl J. , Della Valle M. , de Wet S. , Zafar T. 
Published: July 2024

Context. Long gamma-ray bursts (GRBs) are produced by the collapse of some very massive stars, that emit ultra-relativistic jets. When the jets collide with the interstellar medium they decelerate and generate the so-called afterglow emission, which has been observed to be polarised.
Aims. We study the polarimetric evolution of the GRB 210610B afterglow, at z = 1.1341. This allows us to evaluate the role of geometric and/or magnetic mechanisms in the GRB afterglow polarisation.
Methods. We observed GRB 210610B using imaging polarimetry with CAFOS on the 2.2 m Calar Alto Telescope and FORS2 on the 4 × 8.1 m Very Large Telescope. Complementary optical spectroscopy was obtained with OSIRIS on the 10.4 m Gran Telescopio Canarias. We studied the GRB light-curve from X-rays to the optical bands and the Spectral Energy Distribution (SED). This allowed us to strongly constrain the line-of-sight extinction. Finally, we studied the GRB host galaxy using optical to NIR data to fit the SED and derive its integrated properties.
Results. GRB 210610B had a bright afterglow with a negligible line-of-sight extinction. Polarimetry was obtained at three epochs: during an early plateau phase, at the time when the light curve breaks, and after the light curve steepened. We observe an initial polarisation of ∼4% that goes to zero at the time of the break, and it then again increases to ∼2%, with a change in the position angle of 54 ± 9 deg. The spectrum shows features with very low equivalent widths. This indicate a small amount of material in the line of sight within the host.
Conclusions. The lack of dust and the low amount of material in the line of sight to GRB 210610B allowed us to study the intrinsic polarisation of the GRB optical afterglow. The GRB polarisation signals are consistent with ordered magnetic fields in refreshed shock or/and hydrodynamics-scale turbulent fields in the forward shock.