bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using publicly available, interactive epidemiological dashboards: an innovative approach to sharing data from the Rakai Community Cohort Study
Authors: Footer Kevin , Lake Camille M , Porter Joshua R , Ha Grace K , Ahmed Tanvir , Glogowski Alex , Ndyanabo Anthony , Grabowski M Kate , Chang Larry W , Ssekasanvu Joseph , Kagaayi Joseph , Serwadda David M , Mckina Jackie , Whalen Christopher , Ssentongo Lloyd , Nsimbi Ivan , Kakeeto Benedicto , Kigozi Godfrey , Ssekubugu Robert , Lutalo Tom , Wawer Maria J , Gray Ronald H , Reynolds Steven J , Rosenthal Alex , Quinn Thomas C , Tartakovsky Michael 
Published: July 2024

Abstract

Objectives
Public sharing of de-identified biomedical data promotes collaboration between researchers and accelerates the development of disease prevention and treatment strategies. However, open-access data sharing presents challenges to researchers who need to protect the privacy of study participants, ensure that data are used appropriately, and acknowledge the inputs of all involved researchers. This article presents an approach to data sharing which addresses the above challenges by using a publicly available dashboard with de-identified, aggregated participant data from a large HIV surveillance cohort.

Materials and Methods
Data in this study originated from the Rakai Community Cohort Study (RCCS), which was integrated into a centralized data mart as part of a larger data management strategy for the Rakai Health Sciences Program in Uganda. These data were used to build a publicly available, protected health information (PHI)-secured visualization dashboard for general research use.

Results
Using two unique case studies, we demonstrate the capability of the dashboard to generate the following hypotheses: firstly, that HIV prevention strategies ART and circumcision have differing levels of impact depending on the marital status of investigated communities; secondly, that ART is very successful in comparison to circumcision as an interventional strategy in certain communities.

Discussion
The democratization of large-scale anonymized epidemiological data using public-facing dashboards has multiple benefits, including facilitated exploration of research data and increased reproducibility of research findings.

Conclusion
By allowing the public to explore data in depth and form new hypotheses, public-facing dashboard platforms have significant potential to generate new relationships and collaborations and further scientific discovery and reproducibility.
Causal relationships between height and weight with distal tibia microarchitecture and geometry in adult female twin pairs
Authors: Nissen Frida Igland , Esser Vivienne F C , Bjørnerem Åshild , Hansen Ann Kristin 
Published: July 2024

Abstract
Higher stature and lower weight are associated with increased risk of fracture. However, the pathophysiology for the associations of height and weight with bone microarchitecture and geometry is unclear. We examined whether these associations were consistent with causation and/or with shared familial factors. In this cross-sectional study of 566 female twins aged 26-76 yr, a regression analysis for twin data, Inference about Causation by Examination of FAmilial CONfounding (ICE FALCON), was used for testing causation. The bone microarchitecture and geometry of the distal tibia was assessed using HR-pQCT and the StrAx1.0 software. Higher stature was associated with larger total bone cross-sectional area (CSA), lower total bone volumetric bone mineral density (vBMD), larger cortical CSA, thinner cortices, higher porosity of the total cortex, compact cortex, outer and inner transitional zone (TZ), lower cortical vBMD, and larger medullary CSA (regression coefficients (β) ranging from −.37 to .60, all p&lt;.05). Using ICE FALCON, the cross-pair cross-trait associations attenuated toward zero after adjusting for the within-individual association (absolute values of β ranging from .05 to .31, all p&lt;.001). Higher weight was associated with higher total bone vBMD, larger cortical CSA and thicker cortices, lower porosity of the total cortex and inner TZ, and higher cortical vBMD (β ranging from −.23 to .34, all p&lt;.001), and thinner trabeculae, higher trabecular number, lower trabecular separation, and higher trabecular vBMD (β ranging from −.31 to .39, all p&lt;.05). Only cortical CSA attenuated toward zero after adjusting for the within-individual association between weight and bone microarchitecture (β = .042, p=.046). Higher stature was associated with a weaker cortical, not trabecular bone traits, whereas higher weight was associated with stronger cortical and trabecular bone traits. The results were consistent with height having a causal effect on weaker cortical bone structure, whereas weight had a casual effect on the larger cortical CSA.
Feeding habits of the deep-sea shrimp Plesionika quasigrandis Chace, 1985 (Decapoda: Caridea: Pandalidae) in the southeastern Arabian Sea
Authors: Chakraborty Rekha Devi , Sivasankaran Sreelakshmy , Thanku Sarada P , Lakshmanan Sreesanth 
Published: July 2024

ABSTRACT
Species of PlesionikaSpence Bate, 1888 holds significant importance in the commercial harvesting of deep-sea shrimps along the southern coasts of India. Despite Plesionika quasigrandisChace, 1985 being a crucial resource on the southwest coast of India, there is a need for comprehensive information on its food and feeding habits. We investigated the diet of P. quasigrandis in relation to sex, size, and season. The species exhibited a diet primarily consisting of crustaceans, foraminiferans, and detritus. Both males and females showed a noteworthy reliance on detritus, as indicated by an index of preponderance values exceeding 45.8. The species displayed active scavenging behaviour alongside predatory dietary habits. We observed a decrease in feeding intensity from pre-monsoon to post-monsoon in both males and females. Permutational multivariate analysis of variance (PERMANOVA) revealed significant differences in the diets of P. quasigrandis, considering the combined effects of size and sex (P &lt; 0.01). No significant distinctions were noted in the diet composition between males and females in relation to season.
Money and cooperative federalism: evidence from EPA civil litigation
Authors: González Juan Pablo , You Hye Young 
Published: July 2024

Abstract
The federalism structure of the US government requires active cooperation from state governments to successfully enforce federal environmental regulations. What explains the variation in state governments’ participation in lawsuits against firms that are accused of violating major environmental statutes? We argue that firms’ political connections with state politicians affect a state government’s decision to join the litigation process. By constructing a novel dataset on the EPA’s civil cases and settlements for the period 1998–2021, we show that state environmental agencies are less likely to join the EPA in court when the defendant firms contributed to Republican state legislators. We do not find the same pattern when firms have connections with Democratic legislators. We present various mechanisms of how state politicians influence behaviors of state bureaucrats. Our findings highlight how state politics can be an avenue for firms to exert influence on federal environmental regulations.
Primary left intrathoracic extrapulmonary trans-diaphragmatic hydatid cyst causing eventration: first case in literature
Authors: Haddad Saddik , Bashour George , Kaada Hussein , Rajab Samer , Al-Janabi Moatasem Hussein , Alshehabi Zuheir 
Published: July 2024

Abstract
Hydatidosis is a zoonotic parasitic disease caused by the cystic stage of Echinococcus species. Intrathoracic extrapulmonary hydatid cysts causing eventration are very rare. Here, we report a case of a 62-year-old female who presented with chest pain, intermittent coughing, general weakness, and fever. On auscultation, there were diminished respiratory sounds at the base of the left lung. A computed tomography scan showed a cystic formation with an ambiguous location involving the left lower thorax and the left hypochondrium. Complete surgical resection is the standard treatment for intrathoracic extrapulmonary hydatid cysts. Due to the direct bordering of the cyst with the pericardium in the left cadiophrenic angle, a cystotomy and evacuation of the cystic cavity were performed, followed by washing it with povidone and hyperosmolar saline. The location of the hydatid cyst has an important role in determining the surgical approach, as the unusual location could affect the possibility of radically removing the cyst.
Revision total en bloc spondylectomy for a recurrent aggressive vertebral haemangioma of the thoracic spine causing progressive thoracic myelopathy with segmental kyphosis
Authors: Potparić Igor , Brumat Peter , Bošnjak Klemen , Vodičar Miha 
Published: July 2024

Abstract
Vertebral haemangiomas are common amongst primary benign tumours of the spine, usually asymptomatic and discovered incidentally, whereby symptomatic cases are rare. Aggressive vertebral haemangiomas, occurring even less frequently, are characterized by their expansion, resulting in pain and neural compression symptoms. Depending on presentation and severity, several treatment options exist, and when causing progressive neurological deficit, surgical decompression and resection is warranted. Despite local recurrence being rare, regular follow-ups to detect recurrence are advised. In case of recurrent aggressive vertebral haemangiomas, however, subsequent treatment strategy usually depends on a case-by-case consideration, whereby reports in the literature are lacking. We describe a case of a recurrent aggressive vertebral haemangiomas of the thoracic spine in a 20-year-old male causing progressive thoracic myelopathy with segmental kyphosis, treated with a revision total en bloc spondylectomy and a multilevel fixation with vertebral column reconstruction using radiolucent instrumentation.
Unraveling Eileen Chang’s stylistic multiverse: insights from multivariate analysis with multifactorial design
Authors: Wu Kan , Li Defeng 
Published: July 2024

Abstract
This study employs multivariate analysis within a multifactorial design to investigate the author-translator style of distinguished Chinese author Eileen Chang. Using principal component analysis (PCA) and linear discriminant analysis (LDA), it examines Chang’s stylistic multiverse across three literary types: original writing, self-translation, and regular translation of others’ works. The findings reveal diverse patterns of stylistic convergence and divergence among these literary types, analyzed using the metrics of the most frequent words: 200-MFW, 20-MFW, and 5-MFW. These patterns are shaped by the perspectives introduced by two explanatory factors, translation status (original versus translated) and translation type (self-translation versus regular translation), and influenced by Chang’s literary ambition, translation philosophy, and patronage. The study contributes methodologically to author-translator style research by demonstrating the effectiveness of multifactorial and multivariate approaches, which not only provide profound insights into datasets but facilitate methodological triangulation.
Trypanosome mRNA recapping is triggered by hypermethylation originating from cap 4
Authors: Ignatochkina Anna V , Iguchi Jesavel A , Kore Anilkumar R , Ho C Kiong 
Published: July 2024

Abstract
RNA methylation adjacent to the 5′ cap plays a critical role in controlling mRNA stability and protein synthesis. In trypanosomes the 5′-terminus of mRNA is protected by hypermethylated cap 4. Trypanosomes encode a cytoplasmic recapping enzyme TbCe1 which possesses an RNA kinase and guanylyltransferase activities that can convert decapped 5′-monophosphate-terminated pRNA into GpppRNA. Here, we demonstrated that the RNA kinase activity is stimulated by two orders of magnitude on a hypermethylated pRNA derived from cap 4. The N6, N6-2′-O trimethyladenosine modification on the first nucleotide was primarily accountable for enhancing both the RNA kinase and the guanylyltransferase activity of TbCe1. In contrast, N6 methyladenosine severely inhibits the guanylyltransferase activity of the mammalian capping enzyme. Furthermore, we showed that TbCmt1 cap (guanine N7) methyltransferase was localized in the cytoplasm, and its activity was also stimulated by hypermethylation at 2′-O ribose, suggesting that TbCe1 and TbCmt1 act together as a recapping enzyme to regenerate translatable mRNA from decapped mRNA. Our result establishes the functional role of cap 4 hypermethylation in recruitment and activation of mRNA recapping pathway. Methylation status at the 5′-end of transcripts could serve as a chemical landmark to selectively regulate the level of functional mRNA by recapping enzymes.
IgA class-switched CD27−CD21+ B cells in IgA nephropathy
Authors: Popova Anna , Slisere Baiba , Racenis Karlis , Kuzema Viktorija , Karklins Roberts , Saulite Mikus , Seilis Janis , Saulite Anna Jana , Vasilvolfa Aiga , Vaivode Kristine , Pjanova Dace , Kroica Juta , Cernevskis Harijs , Lejnieks Aivars , Petersons Aivars , Oleinika Kristine 
Published: July 2024

ABSTRACT

Background
Immunoglobulin A nephropathy (IgAN) is characterized by the production of galactose-deficient IgA1 (GdIgA1) antibodies. As the source of pathogenic antibodies, B cells are central to IgAN pathogenesis, but the B cell activation pathways as well as the potential B cell source of dysregulated IgA secretion remain unknown.

Methods
We carried out flow cytometry analysis of peripheral blood B cells in patients with IgAN and control subjects with a focus on IgA-expressing B cells to uncover the pathways of B cell activation in IgAN and how these could give rise to pathogenic GdIgA1 antibodies.

Results
In addition to global changes in the B cell landscape—expansion of naïve and reduction in memory B cells—IgAN patients present with an increased frequency of IgA-expressing B cells that lack the classical memory marker CD27, but are CD21+. IgAN patients furthermore have an expanded population of IgA+ antibody-secreting cells, which correlate with serum IgA levels. Both IgA+ plasmabalsts and CD27− B cells co-express GdIgA1. Implicating dysregulation at mucosal surfaces as the driver of such B cell differentiation, we found a correlation between lipopolysaccharide in the serum and IgA+CD27− B cell frequency.

Conclusion
We propose that dysregulated immunity in the mucosa may drive de novo B cell activation within germinal centres, giving rise to IgA+CD27− B cells and subsequently IgA-producing plasmablasts. These data integrate B cells into the paradigm of IgAN pathogenesis and allow further investigation of this pathway to uncover biomarkers and develop therapeutic interventions.
Assessing the Predictive Value of Methicillin-Resistant Staphylococcus aureus Nares Colonization Among Transplant Recipients and Patients With Neutropenia
Authors: Shaw Reid , Zander Alison , Ronnie Tanisha , Azari Zubeen , Gregorowicz Alex , Albarillo Fritzie 
Published: July 2024

Abstract

Background
Methicillin-resistant Staphylococcus aureus (MRSA) nares screening has been shown to be a powerful antibiotic stewardship tool for MRSA infections within 7 days of screening across a variety of anatomical locations given the high negative predictive value (NPV). However, the utility outside of 7 days and among transplant recipients and patients with neutropenia is less clear.

Methods
This was a retrospective cohort study across Veterans Affairs medical centers in the United States from 1 January 2007 to 1 January 2023 of patients tested for MRSA colonization and who had a subsequent positive bacterial culture within 28 days of MRSA sc­­­reening. Sensitivity, specificity, positive predictive value, and NPV were calculated across different time points and anatomical culture locations.

Results
The cohort consisted of 686 174 patients, 6 277 437 MRSA nares tests, and 2 446 766 positive bacterial cultures within 28 days of MRSA testing. The NPV of MRSA nares screening for ruling out a MRSA infection within 28 days was 95.8% across all anatomical culture sites. The NPV was 97.9% among patients with neutropenia and 97.5% in solid organ and hemopoietic stem cell transplant recipients.

Conclusions
MRSA nares screening can reliably be used for de-escalation of anti-MRSA therapy within 28 days of bacterial culture for all patients, including solid organ and hematopoietic transplant recipients and patients with neutropenia.
Mycoplasma genitalium Incidence, Coinfection, and Antibiotic Resistance: A Prospective Study at a Walk-In Clinic in Los Angeles County, CA
Authors: Sukhija-Cohen Adam Carl , Patani Henna , Robinson Antigone Contessa , Santos Matthew Ramos , Granados Yancy 
Published: July 2024

Abstract
Among 98 participants with penile discharge symptoms of Chlamydia trachomatis or Neisseria gonorrhoeae at a walk-in sexual health clinic, 11 were diagnosed with Mycoplasma genitalium, 10 had antibiotic resistance, and 6 were incorrectly presumptively treated. Our findings highlight the importance of public health strategies and research to curb M genitalium.
Mapping the moral foundations of the European Union: Why a lack of moral diversity may undermine perceived EU legitimacy
Authors: Grosfeld Eva , Scheepers Daan , Cuyvers Armin 
Published: July 2024

Abstract
The stability and effectiveness of supranational organizations, like the European Union (EU), will improve when citizens perceive them as legitimate. Across three studies, two of which were preregistered, and a preregistered pilot study, we combined EU legal expertise with social psychological theory on morality to understand how perceived EU legitimacy is influenced by a sense of moral alignment with the EU. We propose that, currently, the EU gives more weight to values linked to “individualizing” moral foundations (e.g. compassion, social justice, and equality) than to values linked to “binding” moral foundations (e.g. patriotism, religion, and traditionalism). As this may leave people who endorse binding moral foundations feel unrepresented, we investigated whether the EU could gain legitimacy by appealing to values that resonate with binding moral foundations. In study 1, text analyses revealed that the European Commission President's State of the Union speeches indeed appeal more to individualizing than to binding moral foundations. Study 2 (n = 595) provided correlational evidence that the negative relationship between binding moral foundations and perceived EU legitimacy was mediated by lower moral alignment with EU law. Finally, study 3 (n = 567) showed through an experiment that reframing or rebalancing EU law to better align it with binding moral foundations could increase perceived EU legitimacy among people who endorse these moral foundations. The results illustrate the importance of understanding and attending to moral diversity among EU citizens. More generally, our work shows how a collaboration between social psychology and law contributes to safeguarding the legitimacy of supranational organizations.
A Matter of Misunderstanding? Explaining (Mis)Perceptions of Electoral Integrity across 25 Different Nations
Authors: Vliegenthart Rens , Van Ham Carolien , Kruikemeier Sanne , Jacobs Kristof 
Published: July 2024

Abstract
In this paper, we investigate how trust in traditional and social media correlate with misperceptions of electoral integrity. Relying on insights from political communication research on exposure to misinformation and selective exposure mechanisms, as well as insights on the different roles of traditional and social media in different regime types, we argue that misperceptions of election integrity are likely driven in large part by the interplay between the trust people have in different media sources and the context (i.e., the level of press freedom) in which the elections take place. Using data from a survey conducted in 25 countries across the world, we find that trust in information from traditional media decreases misperceptions, while trust in information from social media increases misperceptions. However, both these effects are smaller when press freedom is restricted. In countries with low levels of press freedom, trust in social media is even associated with lower levels of misperceptions.
Prestroke Physical Activity Matters for Functional Limitations: A Longitudinal Case–Control Study of 12,860 Participants
Authors: van Allen Zachary M , Orsholits Dan , Boisgontier Matthieu P 
Published: July 2024

Abstract

Objective
In the chronic phase after a stroke, limitations in basic activities of daily living (ADLs) and instrumental activities of daily living (IADLs) initially plateau before steadily increasing. The benefits of prestroke physical activity on these limitations remain unclear. To clarify this relationship, the effect of physical activity on the long-term evolution of functional limitations in a cohort of people with stroke compared to a cohort of matched adults without stroke was examined.

Methods
Longitudinal data from 2143 people with stroke and 10,717 adults without stroke aged 50 years and older were drawn from a prospective cohort study based on the Survey of Health, Ageing and Retirement in Europe (2004–2022; eight data collection waves). Physical activity was assessed in the prestroke wave. Functional limitations were assessed in the poststroke waves. Each person with stroke was matched with five adults without stroke who had similar propensity scores computed on the basis of key covariates, including baseline age, sex, body mass index, limitations in ADLs and IADLs, chronic conditions, and country of residence, before any of the participants from either cohort had experienced a stroke.

Results
Results showed an interaction between stroke status and physical activity on ADL limitations (b = −0.076; 95% CI = −0.142 to −0.011), with the beneficial effect of physical activity being stronger in people with stroke (b = −0.345; 95% CI = −0.438 to −0.252) than in adults without stroke (b = −0.269; 95% CI = −0.269 to −0.241).

Conclusion
The beneficial effect of prestroke physical activity on ADL limitations after stroke is stronger than its effect in matched adults without stroke followed for a similar number of years.

Impact
Physical activity, an intervention within the physical therapist’s scope of practice, is effective in reducing the risk of functional dependence after stroke. Moreover, prestroke levels of physical activity can inform the prognosis of functional dependence in people with stroke.
Speaker–listener neural coupling correlates with semantic and acoustic features of naturalistic speech
Authors: Li Zhuoran , Hong Bo , Nolte Guido , Engel Andreas K , Zhang Dan 
Published: July 2024

Abstract
Recent research has extensively reported the phenomenon of inter-brain neural coupling between speakers and listeners during speech communication. Yet, the specific speech processes underlying this neural coupling remain elusive. To bridge this gap, this study estimated the correlation between the temporal dynamics of speaker–listener neural coupling with speech features, utilizing two inter-brain datasets accounting for different noise levels and listener’s language experiences (native vs. non-native). We first derived time-varying speaker–listener neural coupling, extracted acoustic feature (envelope) and semantic features (entropy and surprisal) from speech, and then explored their correlational relationship. Our findings reveal that in clear conditions, speaker–listener neural coupling correlates with semantic features. However, as noise increases, this correlation is only significant for native listeners. For non-native listeners, neural coupling correlates predominantly with acoustic feature rather than semantic features. These results revealed how speaker–listener neural coupling is associated with the acoustic and semantic features under various scenarios, enriching our understanding of the inter-brain neural mechanisms during natural speech communication. We therefore advocate for more attention on the dynamic nature of speaker–listener neural coupling and its modeling with multilevel speech features.