bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactive lens through smartphones for supporting level-of-detailed views in a public display
Authors: Kim Minseok , Lee Jae Yeol 
Published: January 2015

AbstractIn this paper, we propose a new approach to providing interactive and collaborative lens among multi-users for supporting level-of-detailed views using smartphones in a public display. In order to provide smartphone-based lens capability, the locations of smartphones are effectively detected and tracked using Kinect, which provides RGB data and depth data (RGB-D). In particular, human skeleton information is extracted from the Kinect 3D depth data to calculate the smartphone location more efficiently and correctly with respect to the public display and to support head tracking for easy target selection and adaptive view generation. The suggested interactive and collaborative lens using smartphones not only can explore local spaces of the shared display but also can provide various kinds of activities such as LOD viewing and collaborative interaction. Implementation results are given to show the advantage and effectiveness of the proposed approach.
A comprehensive approach for managing feasible solutions in production planning by an interacting network of Zero-Suppressed Binary Decision Diagrams
Authors: Takahashi Keita , Onosato Masahiko , Tanaka Fumiki 
Published: January 2015

Abstract
Product Lifecycle Management (PLM) ranges from design concepts of products to disposal. In this paper, we focus on the production planning phase in PLM, which is related to process planning and production scheduling and so on. In this study, key decisions for the creation of production plans are defined as production-planning attributes. Production-planning attributes correlate complexly in production-planning problems. Traditionally, the production-planning problem splits sub-problems based on experiences, because of the complexity. In addition, the orders in which to solve each sub-problem are determined by priorities between sub-problems. However, such approaches make solution space over-restricted and make it difficult to find a better solution. We have proposed a representation of combinations of alternatives in production-planning attributes by using Zero-Suppressed Binary Decision Diagrams. The ZDD represents only feasible combinations of alternatives that satisfy constraints in the production planning. Moreover, we have developed a solution search method that solves production-planning problems with ZDDs. In this paper, we propose an approach for managing solution candidates by ZDDs' network for addressing larger production-planning problems. The network can be created by linkages of ZDDs that express constraints in individual sub-problems and between sub-problems. The benefit of this approach is that it represents solution space, satisfying whole constraints in the production planning. This case study shows that the validity of the proposed approach.
Promotional phrases as questions versus statements: An influence of phrase style on product evaluation
Authors: Hagtvedt Henrik 
Published: January 2015

AbstractThis research investigates consumer responses to simple promotional phrases styled (i.e., framed) as questions versus statements and the moderating role of arousal. Study results indicate that under low arousal, questions have a more favorable influence on product evaluation than statements do; this influence is mediated by the perceived interestingness of the phrase. Under high arousal, the influence is reversed, and it is mediated by perceived clarity. The differential influence of phrase style (framing as question vs. statement) also extends to purchase behavior among consumers in a supermarket.
Non‐invasive sensitive detection of KRAS and BRAF mutation in circulating tumor cells of colorectal cancer patients
Authors: Mohamed Suhaimi Nur-Afidah , Foong Yu Miin , Lee Daniel Yoke San , Phyo Wai Min , Cima Igor , Lee Esther Xing Wei , Goh Wei Lin , Lim Wei-Yen , Chia Kee Seng , Kong Say Li , Gong Min , Lim Bing , Hillmer Axel M. , Koh Poh Koon , Ying Jackie Y. , Tan Min-Han 
Published: January 2015

Characterization of genetic alterations in tumor biopsies serves as useful biomarkers in prognosis and treatment management. Circulating tumor cells (CTCs) obtained non‐invasively from peripheral blood could serve as a tumor proxy. Using a label‐free CTC enrichment strategy that we have established, we aimed to develop sensitive assays for qualitative assessment of tumor genotype in patients. Blood consecutively obtained from 44 patients with local and advanced colorectal cancer and 18 healthy donors were enriched for CTCs using a size‐based microsieve technology. To screen for CTC mutations, we established high‐resolution melt (HRM) and allele‐specific PCR (ASPCR) KRAS‐codon 12/13‐ and BRAF‐codon 600‐ specific assays, and compared the performance with pyrosequencing and Sanger sequencing. For each patient, the resulting CTC genotypes were compared with matched tumor and normal tissues. Both HRM and ASPCR could detect as low as 1.25% KRAS‐ or BRAF‐mutant alleles. HRM detected 14/44 (31.8%) patients with KRAS mutation in CTCs and 5/44 (11.3%) patients having BRAF mutation in CTCs. ASPCR detected KRAS and BRAF mutations in CTCs of 10/44 (22.7%) and 1/44 (2.3%) patients respectively. There was an increased detection of mutation in blood using these two methods. Comparing tumor tissues and CTCs mutation status using HRM, we observed 84.1% concordance in KRAS genotype (p = 0.000129, Fishers' exact test; OR = 38.7, 95% CI = 4.05–369) and 90.9% (p = 0.174) concordance in BRAF genotype. Our results demonstrate that CTC enrichment, coupled with sensitive mutation detection methods, may allow rapid, sensitive and non‐invasive assessment of tumor genotype.
Older adults' meanings of preparedness: a New Zealand perspective
Authors: TUOHY ROBYN , STEPHENS CHRISTINE 
Published: January 2015

ABSTRACTContemporary Western social policy encourages older adults to maintain independence in the community. Socio-cultural norms of independence have recently become associated with successful ageing. Personal autonomy and self-responsibility are cultural markers by which older adults increasingly define their lives and identity. Many older adults seek to remain independent within their communities, while coping with age-related decline, and living alone with decreased social connectedness. These characteristics have also been associated with personal and social vulnerability and explain why older adults are at higher risk of experiencing disproportionate negative outcomes during disasters. This paper describes findings from narrative interviews with a sample of independent community-dwelling New Zealand older adults. The interviews sought to explore their views about disaster preparedness. However, within their accounts was a collective and bigger story about personal preparedness, and social relationships in later life, which extended beyond the context of preparing for a future disaster event. Older adults identified age-specific preparedness as a way to maintain independence in the everyday context of their lives. Concerns about health influenced their choices and actions as they evaluated and prioritised goals and strategies to maintain independence and wellbeing. Social relationships were also considered an important resource to support independence. Understanding the role of preparedness in the everyday lives of older adults has implications for improving the disproportionate negative outcomes this vulnerable age group can experience during a disaster. Therefore, health, gerontology and emergency management have much in common when considering older adults' preparedness during non-disaster times.
Iodine-deficiency disorders in the Aseer region, south-western Saudi Arabia: 20 years after the national survey and universal salt iodization
Authors: Abbag Fuad I , Abu-Eshy Saeed A , Mahfouz Ahmed A , Al-Fifi Suliman A , El-Wadie Hussein , Abdallah Samy M , Musa Mustafa G , Devansan Charles S , Patel Ayuub 
Published: January 2015

AbstractObjectiveTo study (i) the current prevalence of iodine-deficiency disorders among schoolchildren in south-western Saudi Arabia after universal salt iodization and (ii) the iodine content of table salts and water.DesignCross-sectional study on a stratified proportional allocation sample of children. Thyroid gland enlargement was assessed clinically and by ultrasound scanning. Urine, table salt and water samples were taken to measure iodine content.SettingsThe Aseer region, south-western Saudi Arabia.SubjectsSchoolchildren aged 8–10 years.ResultsThe study included 3046 schoolchildren. The total goitre rate amounted to 24·0 %. Prevalence of enlarged thyroid by ultrasound was 22·7 %. The median urinary iodine concentration of the study sample amounted to 17·0 µg/l. The iodine content of table salt ranged from 0 to 112 mg/kg; 22·5 % of the table salt samples were below the recommended iodine content (15 mg/kg) set by WHO. The total goitre rate increased significantly from 19·8 % among children using table salt with iodine content ≥15 mg/kg to reach 48·5 % among children using table salt with 0 mg iodine/kg. Analysis of water samples taken from schools showed that the majority of water samples (78·8 %) had an iodine content of 0 µg/l.ConclusionsThe study documented that 18 years after the national study, and after more than a decade of universal salt iodization in Saudi Arabia, the problem of iodine-deficiency disorders is still endemic in the Aseer region. Efforts should focus on fostering advocacy and communication and ensuring the availability of adequately iodized salt.
Are therapeutic radiographers able to achieve clinically acceptable verification for stereotactic lung radiotherapy treatment (SBRT)?
Authors: Hudson J. , Doolan C. , McDonald F. , Locke I. , Ahmed M. , Gunapala G. , McNair H. 
Published: January 2015

AbstractPurposeThe aim of this study was to assess the feasibility of radiographer led verification of cone-beam computed tomography (CBCT) images for patients with solitary lung tumours treated with stereotactic body radiotherapy treatment (SBRT).Material and methodsCBCT setup images of 20 patients from the first fraction of each patient were retrospectively registered by therapeutic radiographers. The displacements recorded were compared with the clinical oncologist’s original online match. The time taken by radiographers to verify the CBCT images was also recorded.ResultsOverall agreement for all radiographers when compared with the clinical oncologist match was 91%. Interobserver variations between radiographers were X plane 0·87 (0·76–0·94); Y plane 0·74 (0·51–0·88); and Z plane 0·88 (0·78–0·95) intraclass correlation coefficient and 95% confidence interval. The average time taken for verification was 128 seconds.ConclusionTherapeutic radiographers are able to verify CBCT images for thorax SBRT with results comparable to the ‘gold standard’ clinical oncologists’ match, however additional training will be provided for online verification. The time taken was within acceptable limits.
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling
Authors: Goossens Steven , Radaelli Enrico , Blanchet Odile , Durinck Kaat , Van der Meulen Joni , Peirs Sofie , Taghon Tom , Tremblay Cedric S. , Costa Magdaline , Ghahremani Morvarid Farhang , De Medts Jelle , Bartunkova Sonia , Haigh Katharina , Schwab Claire , Farla Natalie , Pieters Tim , Matthijssens Filip , Van Roy Nadine , Best J. Adam , Deswarte Kim , Bogaert Pieter , Carmichael Catherine , Rickard Adam , Suryani Santi , Bracken Lauryn S. , Alserihi Raed , Canté-Barrett Kirsten , Haenebalcke Lieven , Clappier Emmanuelle , Rondou Pieter , Slowicka Karolina , Huylebroeck Danny , Goldrath Ananda W. , Janzen Viktor , McCormack Matthew P. , Lock Richard B. , Curtis David J. , Harrison Christine , Berx Geert , Speleman Frank , Meijerink Jules P. P. , Soulier Jean , Van Vlierberghe Pieter , Haigh Jody J. 
Published: January 2015

AbstractEarly T-cell precursor leukaemia (ETP-ALL) is a high-risk subtype of human leukaemia that is poorly understood at the molecular level. Here we report translocations targeting the zinc finger E-box-binding transcription factor ZEB2 as a recurrent genetic lesion in immature/ETP-ALL. Using a conditional gain-of-function mouse model, we demonstrate that sustained Zeb2 expression initiates T-cell leukaemia. Moreover, Zeb2-driven mouse leukaemia exhibit some features of the human immature/ETP-ALL gene expression signature, as well as an enhanced leukaemia-initiation potential and activated Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signalling through transcriptional activation of IL7R. This study reveals ZEB2 as an oncogene in the biology of immature/ETP-ALL and paves the way towards pre-clinical studies of novel compounds for the treatment of this aggressive subtype of human T-ALL using our Zeb2-driven mouse model.
Volume and porosity thermal regulation in lipid mesophases by coupling mobile ligands to soft membranes
Authors: Parolini Lucia , Mognetti Bortolo M. , Kotar Jurij , Eiser Erika , Cicuta Pietro , Di Michele Lorenzo 
Published: January 2015

AbstractShort DNA linkers are increasingly being exploited for driving-specific self-assembly of Brownian objects. DNA-functionalized colloids can assemble into ordered or amorphous materials with tailored morphology. Recently, the same approach has been applied to compliant units, including emulsion droplets and lipid vesicles. The liquid structure of these substrates introduces new degrees of freedom: the tethers can diffuse and rearrange, radically changing the physics of the interactions. Unlike droplets, vesicles are extremely deformable and DNA-mediated adhesion causes significant shape adjustments. We investigate experimentally the thermal response of pairs and networks of DNA-tethered liposomes and observe two intriguing and possibly useful collective properties: negative thermal expansion and tuneable porosity of the liposome networks. A model providing a thorough understanding of this unexpected phenomenon is developed, explaining the emergent properties out of the interplay between the temperature-dependent deformability of the vesicles and the DNA-mediated adhesive forces.
Adverse Effect of Trauma on Neurologic Recovery for Patients with Cervical Ossification of the Posterior Longitudinal Ligament
Authors: Lee Soo Eon , Jahng Tae-Ahn , Kim Hyun-Jib 
Published: January 2015

Study Design Retrospective study. Objective Minor trauma, even from a simple fall, can often cause cervical myelopathy, necessitating surgery in elderly patients who may be unaware of their posterior longitudinal ligament ossification (OPLL). The aim of this study is to determine the influence of trauma on the neurologic course in patients who have undergone surgery for cervical OPLL. Methods Patients who underwent surgery due to OPLL were divided by trauma history and compared (34 in the trauma group; 70 in the nontrauma group). Results Ground falls were the most common type of trauma (20 patients, low-energy injuries), but 23 patients developed new symptoms after a trauma. Although the symptom duration (17.68 months) was shorter, the Japanese Orthopedic Association (JOA) score and the Nurick scale showed lower values in the trauma group. Trauma histories led patients to earlier hospital visits. Initial JOA scores were associated with a good recovery status upon the last follow-up in both the groups. The narrowest diameter of the spinal canal showed different radiologic parameters: 5.78 mm in the trauma group and 6.52 mm in the nontrauma group. Conclusion Minor trauma can cause the unexpected development of new symptoms in patients unaware of cervical OPLL. Patients with a history of trauma had lower initial JOA scores and showed a narrower spinal canal compared with a nontrauma group. The initial JOA scores were correlated with a good recovery status upon the last follow-up.
Overdose Education and Naloxone Rescue Kits for Family Members of Individuals who Use Opioids: Characteristics, Motivations, and Naloxone Use
Authors: Bagley Sarah M. , Peterson Joanne , Cheng Debbie M. , Jose Charles , Quinn Emily , O'Connor Patrick G. , Walley Alexander Y. 
Published: January 2015

Background In response to the overdose epidemic, a network of support groups for family members in Massachusetts has been providing overdose education and naloxone rescue kits (OEN). The aims of this study were to describe the characteristics, motivations, and benefits of family members who receive OEN and to describe the frequency of naloxone used during an overdose rescue. Methods This cross-sectional, multisite study surveyed attendees of community support groups for family members of opioid users where OEN training was offered using a 42-item self-administered survey that included demographics, relationship to the individual using opioids, experience with overdose, motivations to receive OEN, and naloxone rescue kit use. Results Of 126 attendees who completed surveys at 8 sites, most attendees were white (95%), female (78%), married or partnered (74%), parents of an individual using opioids (85%), and providing financial support for the individual using opioids (52%). The OEN trainees (79%) were more likely than attendees not trained (21%) to be parents of an individual using opioids (91% vs. 65%, P < .05), to provide financial support to an individual using opioids (58% vs. 30%, P < .05), and to have witnessed an overdose (35% vs. 12%, P = .07). The major motivations to receive training were wanting a kit in their home (72%), education provided at the meeting (60%), and hearing about benefits from others (57%). Sixteen parents reported witnessing their child overdose, and 5 attendees had used naloxone successfully during an overdose rescue. Conclusions Support groups for families of people who use opioids are promising venues to conduct overdose prevention trainings because attendees are motivated to receive training and will use naloxone to rescue people when witnessing an overdose. Further study is warranted to understand how to optimize this approach to overdose prevention in the community setting.
Developing differentiation practices: meeting the needs of pupils and teachers
Authors: Simpson Mary 
Published: January 2015

ABSTRACTInvestigations of aspects of differentiation in primary and secondary schools showed that even teachers believed to be ‘good differentiators' have difficulties in allocating tasks to pupils which are appropriate to their attainment levels. Teachers identified a number of key needs to be met if they were to improve differentiation, in particular the need for detailed, manageable, accessible information on pupils' attainments. Among the needs of learners identified by pupils was a need for more information on their learning goals, problems and the means of their solution. A partnership model of assessment is described which has been developed by teachers to meet the needs of both teachers and pupils.
Dilemma and resolution: primary school teachers look beyond Dearing
Authors: Silcock Peter , Wyness Mike 
Published: January 2015

ABSTRACTDuring an hiatus in reform created by the implementation of Sir Ron Dearing's revisions of the English/Welsh National Curriculum, forty primary school practitioners were interviewed about the way their jobs have changed over recent years, and whether the recent SCAA revisions address their difficulties. They were asked about relationships with colleagues, pupils, parents and inspectors and given the opportunity to advise on the way ahead. Their responses were analysed as five practical dilemmas summarized under two headings: (1) whether to embrace the trend towards standardization and central control built into the ERA or try to adapt its changes towards the diverse, individualistic (child‐centred) ethos of British primary schools; (2) whether to work for co‐operation with others in the face of challenges or compete for resources and clientele. Practitioners were found, generally, to interpret reforms in ways allowing them to retain their current personal philosophies and practices, while preferring co‐operative to competitive modes of relationship with colleagues, pupils, parents and inspectors.
rbamtools: an R interface to samtools enabling fast accumulative tabulation of splicing events over multiple RNA-seq samples
Authors: Kaisers Wolfgang , Schaal Heiner , Schwender Holger 
Published: January 2015

Abstract
Summary: The open source environment R isf the most widely used software to statistically explore biological data sets including sequence alignments. BAM is the de facto standard file format for sequence alignment. With rbamtools, we provide now a full spectrum of accessibility to BAM for R users such as reading, writing, extraction of subsets and plotting of alignment depth where the script syntax closely follows the SAM/BAM format. Additionally, rbamtools enables fast accumulative tabulation of splicing events over multiple BAM files.
Availability and implementation: rbamtools is available on CRAN and on R-Forge.
Contact: kaisers@med.uni-duesseldorf.de
Supplementary information: Supplementary data are available at Bioinformatics online.
Development of an expert professional curriculum for antimicrobial pharmacists in the UK
Authors: Sneddon Jacqueline , Gilchrist Mark , Wickens Hayley 
Published: January 2015

Abstract
The role of antimicrobial pharmacists has changed considerably over the past 15 years. We describe here the development and ratification of a new expert professional curriculum to guide the training and development of antimicrobial specialist pharmacists. The curriculum has been developed by the UK Clinical Pharmacy Association Pharmacy Infection Network and endorsed by the Royal Pharmaceutical Society as a tool to support pharmacists in meeting the requirements for joining the Royal Pharmaceutical Society Faculty. This new resource has also been endorsed by PHE, the Scottish Antimicrobial Prescribing Group and the BSAC, and will support antimicrobial pharmacists in delivery of antimicrobial stewardship, which will in turn help the fight against antimicrobial resistance.