bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge domain and emerging trends in the rupture risk of intracranial aneurysms research from 2004 to 2023
Authors: Chen Jun-Chen , Luo Cheng , Li Yong , Tan Dian-Hui 
Published: July 2024

BACKGROUND
Intracranial aneurysms (IAs) pose significant health risks, attributable to their potential for sudden rupture, which can result in severe outcomes such as stroke and death. Despite extensive research, the variability of aneurysm behavior, with some remaining stable for years while others rupture unexpectedly, remains poorly understood.
AIM
To employ bibliometric analysis to map the research landscape concerning risk factors associated with IAs rupture.
METHODS
A systematic literature review of publications from 2004 to 2023 was conducted, analyzing 3804 documents from the Web of Science Core Collection database, with a focus on full-text articles and reviews in English. The analysis encompassed citation and co-citation networks, keyword bursts, and temporal trends to delineate the evolution of research themes and collaboration patterns. Advanced software tools, CiteSpace and VOSviewer, were utilized for comprehensive data visualization and trend analysis.
RESULTS
Analysis uncovered a total of 3804 publications on IA rupture risk factors between 2006 and 2023. Research interest surged after 2013, peaking in 2023. The United States led with 28.97% of publications, garnering 37706 citations. Notable United States-China collaborations were observed. Capital Medical University produced 184 publications, while Utrecht University boasted a citation average of 69.62 per publication. “World Neurosurgery ” published the most papers, contrasting with “Stroke ”, the most cited journal. The PHASES score from “Lancet Neurology ” emerged as a vital rupture risk prediction tool. Early research favored endovascular therapy, transitioning to magnetic resonance imaging and flow diverters. “Subarachnoid hemorrhage ” stood out as a recurrent keyword.
CONCLUSION
This study assesses global IA research trends and highlights crucial gaps, guiding future investigations to improve preventive and therapeutic approaches.
Necrolytic migratory erythema caused by pancreatic hyperglycemia with emphasis on therapeutic and prognosis: A case report
Authors: Zhan Shi-Ping 
Published: July 2024

BACKGROUND
With the incidence of pancreatic diseases increasing year by year, pancreatic hyperglycemia, as one of the common complications, is gradually gaining attention for its impact on the skin health of patients.
CASE SUMMARY
This was the case of an elderly female with clinical manifestations of necrolytic migratory erythema, “three more and one less,” diabetes mellitus, hypertension, anemia, hypoproteinemia, and other syndromes, which had been misdiagnosed as eczema. Abdominal computed tomography showed a pancreatic caudal space-occupying lesion, and the magnetic resonance scanning of the epigastric region with dynamic enhancement and diffusion-weighted imaging suggested a tumor of the pancreatic tail, which was considered to be a neuroendocrine tumor or cystadenoma. The patient was referred to a more equipped hospital for laparoscopic pancreatic tail resection. Post-surgery diagnosis revealed a neuroendocrine tumor in the tail of the pancreas. To date, the patient’s general condition is good, and she is still under close follow-up.
CONCLUSION
Necrolytic migratory erythema can be induced by endocrine system tumors or endocrine metabolic abnormalities, with complex clinical manifestations, difficult diagnosis, and easy misdiagnosis by dermatologists. The initial treatment principles in dermatology include symptomatic supportive therapy and effective drugs to relieve skin lesions. After clarifying the etiology of glucagonoma, comprehensive treatment in collaboration with endocrinologists, general surgeons, and oncologists can help provide individualized treatment for patients and improve their prognosis.
Photonic crystal topological interface state modulation for nonvolatile optical switching
Authors: Quan Zhiqiang , Wang Jian 
Published: July 2024

Phase change materials (PCMs), characterized by high optical contrast (Δn>1), nonvolatility (zero static power consumption), and quick phase change speed (∼ns), provide new opportunities for building low-power and highly integrated photonic tunable devices. Optical integrated devices based on PCMs, such as optical switches and optical routers, have demonstrated significant advantages in terms of modulation energy consumption and integration. In this paper, we theoretically verify the solution for a highly integrated nonvolatile optical switch based on the modulation of the topological interface state (TIS) in the quasi-one-dimensional photonic crystal (quasi-1D PC). The TIS exciting wavelength changes with the crystalline level of the PCM. The extinction ratio (ER) of the topological optical switch is over 18 dB with a modulation length of 9 μm. Meanwhile, the insertion loss (IL) can be controlled within 2 dB. Furthermore, we have analyzed the impact of fabrication errors on the device’s performance. The obtained results show that, the topological optical switch, which changes its “on/off” state by modulating TIS, exhibits enhanced robustness to the fabrication process. We provide an interesting and highly integrated scheme for designing the on-chip nonvolatile optical switch. It offers great potential for designing highly integrated on-chip optical switch arrays and nonvolatile optical neural networks.
Clinical risk factors and blood protein biomarkers of 10-year pneumonia risk
Authors: Lee Ming-Ming , Zuo Yi , Steiling Katrina , Mizgerd Joseph P. , Kalesan Bindu , Walkey Allan J. 
Published: July 2024

Background
Chronic inflammation may increase susceptibility to pneumonia.

Research question
To explore associations between clinical comorbidities, serum protein immunoassays, and long-term pneumonia risk.

Methods
Framingham Heart Study Offspring Cohort participants ≥65 years were linked to their Centers for Medicare Services claims data. Clinical data and 88 serum protein immunoassays were evaluated for associations with 10-year incident pneumonia risk using Fine-Gray models for competing risks of death and least absolute shrinkage and selection operators for covariate selection.

Results
We identified 1,370 participants with immunoassays and linkage to Medicare data. During 10 years of follow up, 428 (31%) participants had a pneumonia diagnosis. Chronic pulmonary disease [subdistribution hazard ratio (SHR) 1.87; 95% confidence interval (CI), 1.33–2.61], current smoking (SHR 1.79, CI 1.31–2.45), heart failure (SHR 1.74, CI 1.10–2.74), atrial fibrillation/flutter (SHR 1.43, CI 1.06–1.93), diabetes (SHR 1.36, CI 1.05–1.75), hospitalization within one year (SHR 1.34, CI 1.09–1.65), and age (SHR 1.06 per year, CI 1.04–1.08) were associated with pneumonia. Three baseline serum protein measurements were associated with pneumonia risk independent of measured clinical factors: growth differentiation factor 15 (SHR 1.32; CI 1.02–1.69), C-reactive protein (SHR 1.16, CI 1.06–1.27) and matrix metallopeptidase 8 (SHR 1.14, CI 1.01–1.30). Addition of C-reactive protein to the clinical model improved prediction (Akaike information criterion 4950 from 4960; C-statistic of 0.64 from 0.62).

Conclusions
Clinical comorbidities and serum immunoassays were predictive of pneumonia risk. C-reactive protein, a routinely-available measure of inflammation, modestly improved pneumonia risk prediction over clinical factors. Our findings support the hypothesis that prior inflammation may increase the risk of pneumonia.
COVID-19: Medical education from the point of view of medical students using the participatory Delphi method
Authors: Ortiz Riofrio Andrea Gabriela , Valdivieso-Andrade Emilia José , Acosta Masaquiza Nathaly Monserrath , Aguirre Alex S. , Almeida Villavicencio Nicolás Alexander , Calderón Pilla Cynthia Samantha , Del Pozo Acosta Prisca , Guaillas Japón Auki , Luna Chonata Darwin Vicente , Mafla Roca Navila Bianca , Mendoza García Alissa Solange , Muñoz Caicedo Lenin Andrés , Muñoz Salazar Gustavo Alexander , Pacheco Reinoso Kimberly Mishell , Pazmiño Chávez Camila Nicole , Proaño Lozada Nuria Karina , Rzonzew Sauer Jonathan , Saldaña Armas Gianny Alexander , Salinas Avalo Ivonne Estefania , Saltos Granizo Ana Cristina , Soria Sarabia Bonny Francisca , Suárez Morales Doménica Alejandra , Sulca Caillagua Rodrigo Felipe , Zavala Cárdenas María Antonia , Carrera Verdesoto Flavio , Cisneros-Heredia Diego , Estrella Porter Pablo , Guillemot Jonathan Raymond 
Published: July 2024

Background
The COVID-19 pandemic has prompted a transformation of medical training. Although there were obvious medical education and social interaction challenges, e-learning presented some advantages, which may have generated medical curricula innovation and adjustments to novel technological methodologies. This study aims to generate consensuses among medical students regarding medical education provided during the pandemic in the resource-limited context of a Global South university.

Methods
The implementation of a participatory Delphi method included a recruitment campaign, training, constitution of Delphi panels and questions, and development of the Delphi exercises. Students from the second to the sixth year of medicine of a university in Quito, Ecuador, constituted two Delphi panels, developed questions about the education received during the pandemic, and answered them over 3.5 rounds.

Findings
Twenty-two medical students participated in the Delphi exercises about their perception of medical education during the COVID-19 pandemic. The analysis consisted of a total of 22 Delphi questions divided into five distinct categories: adaptations and innovations, curriculum and assessment changes, virtual clinical practice, time management, and mental health. The authors established high, medium, and low consensuses for analysis.

Conclusions
Consensuses were reached based on students’ academic year and focused on the changes in lecture delivery, the usage of new technologies, patient care skills, the impact of the educational routine, and the mental health of the COVID-19 pandemic. The way the pandemic affected medical education in the Global South set the stage for the need for a comprehensive review of tools, skills, and curricula for students from culturally diverse backgrounds. This study offers a highly replicable methodology to generate consensuses and introduce students to academic research.
Phenome-wide association study identifies new clinical phenotypes associated with Staphylococcus aureus infections
Authors: Allaire Patrick , Elsayed Noha S. , Berg Richard L. , Rose Warren , Shukla Sanjay K. 
Published: July 2024

BackgroundPhenome-WideAssociation study (PheWAS) is a powerful tool designed to systematically screen clinical observations derived from medical records (phenotypes) for association with a variable of interest. Despite their usefulness, no systematic screening of phenotypes associated withStaphylococcusaureusinfections(SAIs) has been done leaving potential novel risk factors or complications undiscovered.Method and cohortsWe tailored the PheWAS approach into a two-stage screening procedure to identify novel phenotypes correlating with SAIs. The first stage screened for co-occurrence of SAIs with other phenotypes within medical records. In the second stage, significant findings were examined for the correlations between their age of onset with that of SAIs. The PheWAS was implemented using the medical records of 754,401 patients from the Marshfield Clinic Health System. Any novel associations discovered were subsequently validated using datasets from TriNetX andAll of Us, encompassing 109,884,571 and 118,538 patients respectively.ResultsForty-one phenotypes met the significance criteria of a p-value < 3.64e-5 and odds ratios of > 5. Out of these, we classified 23 associations either as risk factors or as complications of SAIs. Three novel associations were discovered and classified either as a risk (long-term use of aspirin) or complications (iron deficiency anemia and anemia of chronic disease). All novel associations were replicated in the TriNetX cohort. In theAll of Uscohort, anemia of chronic disease was replicated according to our significance criteria.ConclusionsThe PheWAS of SAIs expands our understanding of SAIs interacting phenotypes. Additionally, the novel two-stage PheWAS approach developed in this study can be applied to examine other disease-disease interactions of interest. Due to the possibility of bias inherent in observational data, the findings of this study require further investigation.
Obstetrics care in Indonesia: Determinants of maternal mortality and stillbirth rates
Authors: Wenang Supriyatiningsih , Emilia Ova , Wahyuni Alfaina , Afdal Andi , Haier Joerg 
Published: July 2024

Problem
The Indonesian Healthcare Program starting in 2014 enabled access to healthcare delivery for large population groups. Guidance of usage, infrastructure and healthcare process development were the most challenging tasks during the implementation period. Due to the high social impact obstetric care and related quality assurance require evidence-based developmental strategies. This study aims for analysis of outcome and maternal health care utilization, as well as differences related to demographic and economic subgroups.

Methods
For univariate group comparison ANOVA method was applied and combined with Scheffé procedure and Bonferoni correction for post-hoc tests. Meanwhile, multivariate approaches through regression analysis based on insurance reimbursement data antenatal, perinatal and postnatal care were performed at the province level. Maternal mortality (MMR) and stillbirth rates were used for outcome. Demographic characteristics, availability of obstetricians (SPOG), midwifes and healthcare infrastructure were included for their determinants.

Results
Specialized hospital facilities (type A/B) for advanced care covered a large part of uncomplicated cases (~35%). Differences between insurance membership groups (poor, non-poor) were not seen. Availability of human resources (SPOG, midwifes) (R2 = 0.728; p<0.001) and rural setting (R2 = 0.288; p = 0.001) are correlated with reduced insufficient referral. Their presence within provinces was related to lower occurrence of complicated cases (R2 = 0.294; p = 0.001). However, higher SPOG rates within provinces were also related to high C-section rates (p<0.001). MMR and stillbirth rates can be predicted by availability of human resources and C-section rates explaining 49.0% of variance.

Conclusions
Improvement of perinatal outcome should focus on sufficient referral processes, availability of SPOG in provinces dominated by rural/remote demography and avoidance of overtreatment by high C-section rates. It is very important to regulate the education of obstetricians and gynecologists in Indonesia as well as distribution arrangements regarding to solve the problems with pregnancy complications in remote and rural areas.
Malaria transmission blocking activity of Anopheles stephensi alanyl aminopeptidase N antigen formulated with MPL, CpG, and QS21 adjuvants
Authors: Pourhashem Zeinab , Nourani Leila , Pirahmadi Sakineh , Yousefi Hemn , J. Sani Jafar , Raz Abbasali , Zakeri Sedigheh , Dinparast Djadid Navid , Abouie Mehrizi Akram 
Published: July 2024

Backgrounds
Malaria, a preventive and treatable disease, is still responsible for annual deaths reported in most tropical regions, principally in sub-Saharan Africa. Subunit recombinant transmission-blocking vaccines (TBVs) have been proposed as promising vaccines to succeed in malaria elimination and eradication. Here, a provisional study was designed to assess the immunogenicity and functional activity of alanyl aminopeptidase N (APN1) of Anopheles stephensi, as a TBV candidate, administered with MPL, CpG, and QS21 adjuvants in the murine model.

Methodology/Principal findings
The mouse groups were immunized with recombinant APN1 (rAPN1) alone or formulated with CpG, MPL, QS-21, or a combination of adjuvants (CMQ), and the elicited immune responses were evaluated after the third immunization. The standard membrane feeding assay (SMFA) measured the functional activity of antibodies against bacterial-expressed APN1 protein in adjuvanted vaccine groups on transmission of P. falciparum (NF54) to An. stephensi mosquitoes. Evaluation of mice vaccinated with rAPN1 formulated with distinct adjuvants manifested a significant increase in the high-avidity level of anti-APN1 IgG and IgG subclasses; however, rAPN1 induced the highest level of high-avidity anti-APN1 IgG1, IgG2a, and IgG2b antibodies in the immunized vaccine group 5 (APN1/CMQ). In addition, vaccine group 5 (receiving APN1/CMQ), had still the highest level of anti-APN1 IgG antibodies relative to other immunized groups after six months, on day 180. The SMFA data indicates a trend towards higher transmission-reducing activity in groups 2 and 5, which received the antigen formulated with CpG or a combination of three adjuvants.

Conclusions/Significance
The results have shown the capability of admixture to stimulate high-affinity and long-lasting antibodies against the target antigen to hinder Plasmodium parasite development in the mid-gut of An. stephensi. The attained results authenticated APN1/CMQ and APN1/CpG as a potent APN1-based TBV formulation which will be helpful in designing a vaccine in the future.
Unveiling the impact of community knowledge in malaria programmes: A scoping review protocol
Authors: Abdul Rahim Faizul Akmal , Abdul Mutalip Mohd Hatta , Mohd Ngesom Ahmad Mohiddin , Mahmud Mohd Amierul Fikri , Yoep Norzawati 
Published: July 2024

Background
Despite significant reductions in recent malaria cases and deaths globally, the persistence of this health concern necessitates a shift from traditional top-down approaches. Consequently, malaria control initiatives increasingly focus on empowering local communities through community-centred strategies. Therefore, this scoping review protocol systematically explores diverse community knowledge approaches adopted in malaria programmes worldwide and their associated outcomes.

Methods
Adhering rigorously to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines, a comprehensive scoping review protocol was developed. Collaborating with a research librarian, a systematic search strategy targeted peer-reviewed literature from databases such as PubMed, Embase, Scopus, and Web of Science, complemented by a thorough grey literature search. Titles and abstracts will be screened, followed by extracting bibliographic details and outcome information using a standardized framework. Subsequently, the results will be systematically summarized and presented in a structured tabular format (S1 Checklist).

Discussion
This scoping review promises an in-depth understanding of current research regarding the impact of community knowledge in malaria programmes. The identification of knowledge gaps and intervention needs serves as a valuable resource for malaria-affected countries. The profound implications of community knowledge underscore its pivotal role in enhancing the effectiveness of prevention, control, and elimination efforts. Insights from this review will assist policymakers, empowering implementers and community leaders in designing effective interventions. This concerted effort aims to adeptly leverage community knowledge, thereby propelling progress toward the achievement of malaria elimination goals.
Yours Cruelly, Elvira: Memoirs of the Mistress of the Dark, Cassandra Peterson (2021)
Authors: Burger Alissa 
Published: July 2024

Review of: Yours Cruelly, Elvira: Memoirs of the Mistress of the Dark, Cassandra Peterson (2021)
New York: Hachette, 284 pp.,
ISBN 978-0-30687-435-2, h/bk, $29.00
ISBN 978-0-30687-436-9, e-book, $11.99
Normporn: Queer Audiences and the TV that Soothes Us, Karen Tongson (2023)
Authors: Collins Jennifer 
Published: July 2024

Review of: Normporn: Queer Audiences and the TV that Soothes Us, Karen Tongson (2023)
New York: New York University Press, 211 pp.,
ISBN 978-1-47984-399-2, e-book, $19.95
ISBN 978-1-47984-651-1, p/bk, $19.95
ISBN 978-1-47984-192-9, h/bk, $89.00
Determinant factors of obesity in urban and rural studies on adolescents in Banten Province, Indonesia
Authors: Perdanawati Mia , Nugraheni Sri Achadi , Syauqy Ahmad , Noer Etika Ratna , Muniroh Muflihatul 
Published: July 2024

Background: The prevalence of obesity which continues to grow in children and adolescents is a concern since it increases degenerative disease risk. Obesity is not only a problem in urban areas, but it is also growing in rural areas.Objective: The aim of this study was to analyze the determinants of obesity in adolescents in rural and urban areas in Banten Province.Materials and Methods: This research design used a case-control method with a purposive sampling technique. The sample in the study consisted of 160 adolescent subjects from 2 different schools. Each school representing 40 case samples that were adolescents with obesity and control adolescents with a normal body mass index. This study was conducted at one school in Cilegon City to represent the urban sample and one school in Pandeglang Regency to represent the rural sample. For each sample, body weight and height were measured, filling out the SQ-FFQ, International Physical Activity Questioner (IPAQ), Pittsburgh Sleep Quality Index and DASS-42 (Depression Anxiety Stress Scale) questionnaires. Data regarding the results of air quality monitoring which includes data (PM10, SO2 O3 and NO2) was obtained from the Environmental Service. Meanwhile, data were analyzed by using Chi-Square and logistic regression.Results: The determinants of obesity in adolescents in rural were protein intake more than RDA (p=0.003 OR=9.948), low physical activity (P=0.005 OR=22.094), high of SO2 exposure (P=0.005 OR=19.817) and bad sleep quality (P=0.007 OR=8.901) while adolescents in urban were protein intake more than RDA (p=0.001 OR=21.570), bad sleep quality (p=0.002 OR=16.550), high stress level (p=0.006 OR=15.922) and carbohydrate intake more than RDA (p=0.072 OR=5.044).Conclusion: Protein intake is the biggest determinant of the incidence of obesity in adolescents both in rural and urban areas.
Vpliv morfologije cvetov na oploditev in pridelek pri vinski trti (Vitis vinifera L. cv. 'Pikolit')
Authors: RUSJAN Denis , KOROŠEC-KORUZA Zora , TOMAŽIČ Irma 
Published: July 2024

Vitis vinifera L. cv. 'Pikolit' is a white grapevine variety, which production is generally very unstable and very poor. The vine express flower-shedding, which can be explained by several causes: physiological, pathological, genetic, ecological and nutritional. Flower-shedding has been studied at collection vineyard of Dobrovo in Goriška Brda. The variable studied was the impact of a different distance of cv. 'Pikolit' from a plantation of pollination vine cv. 'Rebula' on the quality and quantity of the crop. The grapevines have been devided into four groups; A (grapevines near pollinator), B (control grapevines), C (grapevines with isolation flowers) and pollinator group cv. 'Rebula'. The proximity of the pollination vine showed to be in direct correlation with the quality and quantity of cv. 'Pikolit' crop. The cause for this phenomena is a morfological one as cv. 'Pikolit' has functional female flower, which disable autofertilisation. Furthermore, the pollen itself is not fertile.