bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring rose absolute and phenylethyl alcohol as novel quorum sensing inhibitors in Pseudomonas aeruginosa and Chromobacterium violaceum
Authors: Çevikbaş Halime , Ulusoy Seyhan , Kaya Kinaytürk Neslihan 
Published: July 2024

AbstractInter-cellular signaling, referred to as quorum sensing (QS), regulates the production of virulence factors in numerous gram-negative bacteria, such as the human pathogens Pseudomonas aeruginosa and Chromobacterium violaceum. QS inhibition may provide an opportunity for the treatment of bacterial infections. This represents the initial study to examine the antibiofilm and antivirulence capabilities of rose absolute and its primary component, phenylethyl alcohol. QS inhibition was assessed by examining extracellular exopolysaccharide synthesis, biofilm development, and swarming motility in P. aeruginosa PAO1, along with violacein production in C. violaceum ATCC 12472. Molecular docking analysis was conducted to explore the mechanism by which PEA inhibits QS. Our results indicate that rose absolute and PEA caused decrease in EPS production (60.5–33.5%), swarming motility (94.7–64.5%), and biofilm formation (98.53–55.5%) in the human pathogen P. aeruginosa PAO1. Violacein production decreased by 98.1% and 62.5% with an absolute (0.5 v/v %) and PEA (2 mM). Moreover, the molecular docking analysis revealed a promising competitive interaction between PEA and AHLs. Consequently, this study offers valuable insights into the potential of rose absolute and PEA as inhibitors of QS in P. aeruginosa and C. violaceum.
Complex patterns of multimorbidity associated with severe COVID-19 and long COVID
Authors: Pietzner Maik , Denaxas Spiros , Yasmeen Summaira , Ulmer Maria A. , Nakanishi Tomoko , Arnold Matthias , Kastenmüller Gabi , Hemingway Harry , Langenberg Claudia 
Published: July 2024

Abstract
Background
Early evidence that patients with (multiple) pre-existing diseases are at highest risk for severe COVID-19 has been instrumental in the pandemic to allocate critical care resources and later vaccination schemes. However, systematic studies exploring the breadth of medical diagnoses are scarce but may help to understand severe COVID-19 among patients at supposedly low risk.

Methods
We systematically harmonized >12 million primary care and hospitalisation health records from ~500,000 UK Biobank participants into 1448 collated disease terms to systematically identify diseases predisposing to severe COVID-19 (requiring hospitalisation or death) and its post-acute sequalae, Long COVID.

Results
Here we identify 679 diseases associated with an increased risk for severe COVID-19 (n = 672) and/or Long COVID (n = 72) that span almost all clinical specialties and are strongly enriched in clusters of cardio-respiratory and endocrine-renal diseases. For 57 diseases, we establish consistent evidence to predispose to severe COVID-19 based on survival and genetic susceptibility analyses. This includes a possible role of symptoms of malaise and fatigue as a so far largely overlooked risk factor for severe COVID-19. We finally observe partially opposing risk estimates at known risk loci for severe COVID-19 for etiologically related diseases, such as post-inflammatory pulmonary fibrosis or rheumatoid arthritis, possibly indicating a segregation of disease mechanisms.

Conclusions
Our results provide a unique reference that demonstrates how 1) complex co-occurrence of multiple – including non-fatal – conditions predispose to increased COVID-19 severity and 2) how incorporating the whole breadth of medical diagnosis can guide the interpretation of genetic risk loci.
A circular switched parasitic array with directors for LoRa applications at 868 MHz
Authors: Reinhold Lukas , Wasle Casper , Kölpin Alexander 
Published: July 2024

AbstractThe integration of directive elements into a circular switched parasitic array at 868 MHz is presented. The typical usage of reflective parasitic monopoles is supplemented with additional, shorter monopole elements which are positioned closer to the central active monopole to induce directive behaviour. This allows for more degrees of freedom with the steering of the antennas beam and to increase the gain of the antenna. This leads to a greater flexibility of the system and enables power reduction of the amplifiers for enhanced battery life time. The design and configuration of a circular switched parasitic array with directive elements is shown and a prototype is built for validation.
Transient and steady‐state performance improvement of two interconnected areas through VSC‐based HVDC transmission line using multi‐purpose control strategies
Authors: Faraji Hossien , Khorsandi Amir , Hosseinian Seyed Hossein 
Published: July 2024

AbstractThis paper presents various control strategies to improve operations in two interconnected areas connected by a VSC‐HVDC transmission line. The main focus is on designing a central control system (CCS) that coordinates control units in both areas. In area 1, an AC voltage control unit is connected to the CCS. In area 2, three control units including a load power control unit, a fault detection unit, and an AC voltage control unit are also connected to the CCS. The CCS receives inputs from these units and generates commands for the DC voltage and active/reactive power control units on both sides of the DC line. The first proposed strategy addresses permanent voltage drops caused by load fluctuations in area 2. It adjusts the transmitted power from area 1 based on voltage variations in area 2. The second strategy focuses on mitigating faults in area 2 by injecting active and reactive power from area 1 during such events. The third strategy resolves transient voltage oscillations in both areas by controlling the reactive power of stations on either side of the DC line. Simulations using MATLAB‐SIMULINK demonstrate that these mechanisms successfully achieve their objectives.
CFDI: Coordinated false data injection attack in active distribution network
Authors: Liu Yang , Yang Chenyang , Yu Nanpeng , Wang Jiazhou , Tian Jue , Huang Hao , Zhou Yadong , Liu Ting 
Published: July 2024

AbstractThe active distribution network (ADN) can obtain measurement data, estimate system states, and control distributed energy resources (DERs) and flexible loads to ensure voltage stability. However, the ADN is more vulnerable to cyber attacks due to the recent wave of digitization and automation efforts. In this article, false data injection (FDI) attacks are focused on and they are classified into two types, that is, type I attacks on measurement data and type II attacks on control commands. After studying the impact of these two FDI attacks on the ADN, a new threat is revealed called coordinated FDI attack, which can maximize the voltage deviation by coordinating type I and type II FDI attacks. From the attacker's perspective, the scheme of CFDI is proposed and an algorithm is developed to find the optimal attack strategy. The feasibility of CFDI attacks has been validated on a smart distribution testbed. Moreover, simulation results on an ADN benchmark have demonstrated that CFDI attacks could cause remarkable voltage deviation that may deteriorate the stability of the distribution network. Moreover, the impact of CFDI attacks is higher than pure type I or type II attacks. To mitigate the threat, some countermeasures against CFDI attacks are also proposed.
Biomass N/P co‐doped porous carbon plates for electrocatalytic oxygen reduction
Authors: Ma Hongwei , Guo Daying , Wu Lianhui , Chen Xi'an 
Published: July 2024

AbstractNitrogen and phosphorus co‐doped porous carbon plate (NPCP) was prepared by simple pyrolysis carbonization and alkali activation of biomass duckweed NPCP displays the largest specific surface area (SSA) of 2023 m2 g−1, and is rich in pyridine N and P doping, which makes the metal‐free carbon have excellent electrocatalytic oxygen reduction performance. The best NPCP2 shows a half‐wave potential of 0.19 V vs. Ag/AgCl in alkaline electrolyte, and its activity is equivalent to that of commercial platinum carbon (Pt/C). In addition, it shows excellent methanol toxicity resistance and continuous catalytic stability. The experimental results show that the heteroatom doping method obtained by biomass hydroponics has great advantages and great application value in the catalytic field of porous carbon materials.
High power, broadband, coaxial to microstrip bi‐directional coupler in the VHF/UHF band
Authors: Naeimi Tohid , Ahmadi Arash 
Published: July 2024

AbstractBroadband couplers consist usually of multiple coupled lines that are each a quarter wave‐length long. Herein, in contrast to conventional methods, a short length of a microstrip line is coupled to a coaxial line. The length of the coupled microstrip line is small compared to the wavelength at the lowest operating frequency. The coupling is weak and the microstrip line is λ/8 at the highest operating frequency. The proposed structure resembles a pair of coupled lines with a linear coupling response. The coupling exhibits a slope of 6 dB/octave over multi‐octave bandwidth. The microstrip line is connected to a lumped element compensating network at the coupled port. The compensating network is a low‐pass circuit with a slope of −6 dB/octave. The power handling of the coupler is high due to the coaxial line and the weakly coupled microstrip line. Electromagnetic simulations and analytical formulations are presented. The broadband coupler handles nearly 1 kW of input power. Due to the weak coupling of the microstrip‐coaxial coupler, the lumped element circuit needs to handle <1.5 W. A high‐power coupler has been fabricated for the frequency range of 30 to 500 MHz. It exhibits a coupling response of 56 ± 0.4 dB.
Invadosomes
Authors: Gamblin Cécile , Chavrier Philippe 
Published: July 2024

Le terme « invadosome » désigne une famille de structures cellulaires, comprenant les podosomes et les invadopodes, qui constituent des zones de contact entre la membrane plasmique des cellules et la matrice extracellulaire. Ces structures contribuent au remodelage de la matrice grâce à un enrichissement local en enzymes protéolytiques qui dégradent ses constituants fibrillaires. Les invadosomes, présents dans des types cellulaires variés, contribuent à des processus physiologiques, tels que la vascularisation, ou pathologiques, comme l’invasion des tissus par les cellules métastatiques.
Versorgung und Prävention bei Adipositas bei Kindern und Jugendlichen
– Ansätze der Community Medicine
Authors: van den Berg Neeltje , Tomczyk Samuel , Kölch Michael , Schmidt Silke , Heckmann Matthias , Wabitsch Martin 
Published: July 2024

ZusammenfassungCommunity Medicine (CM) verfolgt einen community- und bevölkerungsbezogenen sowie
lebensumspannenden Ansatz für die Gesundheit von Kindern und Jugendlichen. Der
Schwerpunkt liegt auf den Zugangspunkten zu Prävention und Behandlung (d. h.
Zugang und Reichweite), auf der Beschreibung von Veränderungsmechanismen und
CM-Ergebnissen über psychosoziale Prozesse (z. B. in Bezug auf soziale Teilhabe
und Lebensqualität) sowie auf der Ermittlung und Entwicklung von Versorgungs-
und Präventionsnetzwerken, Strukturen und Kontexten für eine erfolgreiche
Entwicklung und Umsetzung von Interventionen und den Transfer von Innovationen
im Gesundheitswesen (d. h. Aufbau von Kapazitäten). Aufbauend auf bestehenden
Telemedizinnetzwerken (z. B. RTP-Net), Kohorten und Fachwissen über Hindernisse
und fördernde Faktoren bei der Inanspruchnahme von Leistungen werden zentrale
Forschungsfragen in Bezug auf Zugang und Reichweite bei chronischen Erkrankungen
untersucht, wobei Adipositas ein Beispiel für eine somatische Erkrankung mit
ausgeprägten psychosozialen Aspekten ist. Um den Zugang zu und die
Erreichbarkeit von Versorgung und Prävention für Kinder und Jugendliche mit
Adipositas zu verbessern, ist ein umfassendes Wissen über individuelle und
institutionelle Faktoren erforderlich, um Barrieren zu identifizieren und
wirksame Interventionen zu entwickeln. Die dafür erforderlichen Studien sollen
innerhalb des Deutschen Zentrums für Kinder- und Jugendgesundheit (DZKJ)
durchgeführt werden.
Adipositasberatungsstelle für Kinder und Jugendliche JumpaKids –
erste positive Erfahrungen
Authors: Leipold Georg , Brenninger Dorothea , Hentschel Raphael 
Published: July 2024

ZusammenfassungAngesichts der weitgehend desolaten Versorgungsstruktur für Kinder und
Jugendliche mit Adipositas, nur 1% wird leitliniengerecht behandelt, wurde 2019
als Modellprojekt eine kommunale Adipositasberatungsstelle in Regensburg mit
multiprofessionellem Team eingerichtet. Innerhalb von knapp 3 Jahren, verschärft
durch die Coronasituation, haben über 230 Klienten und ihre Familien Beratungen
und Angebote für Ernährung, Sport und psychosoziale Beratung angenommen. Nach
mindestens 3 Monaten ließ sich eine BMI-SDS-Reduktion von 0,25 erzielen.
Angesichts des niederschwelligen Zugangs, der häufigen Kontaktaufnahme und des
großen Erfolges sollte eine Aufnahme von Beratungsstellen als feste Säule in ein
strukturiertes Versorgungskonzept für Kinder und Jugendliche mit Adipositas
erwogen werden.
Verbesserungsbedarf in der Versorgung von Patienten/-innen mit Clostridioides-difficile-lnfektionen (CDI) – Experten/-innenmeinung im internationalen Vergleich
Authors: Vehreschild Maria J. G. T. , Schreiber Stefan , von Müller Lutz , Epple Hans-Jörg , Manthey Carolin , Oh Jun , Weinke Thomas , Wahler Steffen , Stallmach Andreas 
Published: July 2024

Zusammenfassung
Einführung Die Clostridioides-difficile-Infektion (CDI) ist mit einer hohen Morbidität und Mortalität assoziiert. Auch wenn ihre Inzidenz in den letzten Jahren in Deutschland rückläufig ist, kann die individuelle Infektion trotz therapeutischen Fortschritts eine medizinische Herausforderung darstellen. Hier soll geklärt werden, welche Lücken verantwortliche Behandler/-innen in der Versorgung und in der Evidenzlage als besonders gravierend ansehen.
Methoden In einem moderierten Workshop von in Deutschland tätigen CDI-Experten/-innen, wurden als relevant eingeschätzte Fragestellungen ermittelt. Eine bereits in fünf anderen Ländern (Australien, Frankreich, Großbritannien, Kanada und Italien) durchgeführte Befragung wurde ergänzend angepasst und von 27 Behandlern/-innen bearbeitet. Bei der Auswertung wurden die als besonders wichtig empfundenen Themen herausgearbeitet, die Aussagen der Fachgruppen verglichen und Meinungsänderungen berücksichtigt.
Ergebnisse 27 vollständig ausgefüllte Fragebögen wurden ausgewertet. Verbesserungsbedarf wurde vorrangig bei der Verhinderung von CDI-Rezidiven (74,1%), sowie Therapie der Rezidive (55,6%) gesehen. Evidenzdefizite wurden bei der Behandlung von Rezidiven (55,6%) und der Identifikation der Risikofaktoren für Rezidive konstatiert (48,1%). Die Verbesserung der Versorgung mittels fäkalem Mikrobiota-Transfer (FMT) nannten 70,4%. Bei Leitlinien wurde mehr Klarheit (48,1%) und regelmäßigere Aktualisierung (40,7%) gewünscht. Für Patienten/-innen wurden bessere Aufklärung der über angemessenen Antibiotikaeinsatz (52,0%) und Wahlmöglichkeiten der FMT angestrebt (48,1%).
Zusammenfassung Bei der Frage nach Verbesserungsbedarf in der Versorgung und Evidenzlücken bei der Behandlung von Patienten/-innen mit CDI ist die nationale Experten/-innensicht in Deutschland, wie auch die internationale Einschätzung ähnlich: Im Zentrum steht die Prävention und Therapie der rezidivierenden CDI. Die Problematik des Zugangs zum FMT ist eine deutsche Besonderheit, die verbesserungspflichtig erscheint.
Venous Thromboembolism: Current Insights and Future Directions
Authors: Mahani Sahar , DiCaro Michael V. , Tak Nadia , Hartnett Sigurd , Cyrus Tillman , Tak Tahir 
Published: July 2024

AbstractVenous thromboembolism (VTE) is the third most common cause of death worldwide even though incidence rates differ globally. Western nations report 1 to 2 cases per 1,000 person-years, while Eastern countries exhibit lower rates (<1 per 1,000 person-years). This comprehensive review delves into diverse VTE risk factors including gender, diabetes, obesity, smoking, genetic mutations, hormonal influences, travel, infections, trauma, and cancer. Notably, VTE incidence is highest in certain cancers (such as pancreatic, liver, and non-small-cell lung cancers) and lowest in others (such as breast, melanoma, and prostate cancers). The extensive review provides essential information about prevalent factors and explores potential molecular mechanism contributing to VTE.
From negative to conjunctive
Authors: Huang Yanxuan , Huang Ruiling , Huang Jiaying 
Published: July 2024

Abstract
In the Jieyang Southern Min dialect, the negative 無 bo55
has evolved into a conjunctive that is used in multiple constructions: negative conditionals, cause and effect, disjunctives, and proposals. This paper aims to describe the multiple functions of 無 bo55
and to construct its grammaticalization path as compared with those of 否則 fouze ‘otherwise or else’, and 要不 yaobu ‘if not’, in Mandarin. It is common in Chinese and other languages for a negative to combine with its adjacent conjunctive to develop a new conjunctive. However, the Jieyang dialect exhibits a unique feature in that 無 bo55
is grammaticalized into a conjunctive per se by applying a complicated process of reasoning involving the logical relations among clauses without the support of any conjunctive constituents. This phenomenon can provide a new model for the study of grammatical evolution.
Relaxation dynamics in the alternating XY chain following a quantum quench
Authors: Cao Kaiyuan , Hu Yayun , Tong Peiqing , Yang Guangwen , Liu Peng 
Published: July 2024

Abstract
We investigate the relaxation dynamics of the fermion two-point correlation function

C

mn

(
t
)
=
〈
ψ
(
t
)
∣

c

m

†

c

n

∣
ψ
(
t
)
〉

in the XY chain with alternating nearest-neighbor hopping interaction after a quench. We find that the deviation δ
C

mn
(t) = C

mn
(t) − C

mn
(∞) decays with time following the power law behavior t
−μ
, where the exponent μ depends on whether the quench is to the commensurate phase (μ = 1) or incommensurate phase (

μ
=

1

2

). This decay of δ
C

mn
(t) arises from the transient behavior of the double-excited quasiparticle occupations and the transitions between different excitation spectra. Furthermore, we find that the steady value C

mn
(∞) only involves the average fermion occupation numbers (i.e. the average excited single particle) over the time-evolved state, which are different from the ground state expectation values. We also observe nonanalytic singularities in the steady value C

mn
(∞) for the quench to the critical points of the quantum phase transitions (QPTs), suggesting its potential use as a signature of QPTs.
Dynamic control of polarization conversion based on borophene nanostructures in optical communication bands
Authors: Wang Xin-Yang , Lin Qi , Wang Ling-Ling , Liu Gui-Dong 
Published: July 2024

Abstract
Polarized light has a number of potential applications in the communication bands, including optical communication, polarization imaging, quantum emission, and quantum communication. Nonetheless, there is a need to enhance the dynamic tunability, broadband operation, and flexibility of polarization control. Here, a borophene structure is proposed to dynamically control the polarization state of reflected light. The coherent excitation of localized surface plasmons (LSPs) empowers the achievement of a perfect linearly-circularly polarization conversion at the commercially important communication wavelength of 1550 nm. The dynamic tunability and switching, as well as the arbitrary polarization conversion, are enabled over a wide spectral range by modulating the carrier concentration of borophene. Moreover, by deforming the borophene array and alternately stimulating the upper and lower layers of the LSPs mode, the polarization rotation direction can be flexibly switched. Finally, the process of near-field coupling between the LSPs and dipole light source positioned at a chosen hotspot is demonstrated. This coupling enables polarization-tunable spontaneous emission enhancement, with a spontaneous emission enhancement exceeding 900. The proposed design contributes to enhancing the speed and efficiency of communication within the domain of quantum communication.
Sand mining across the Ganges–Brahmaputra–Meghna Catchment; assessment of activity and implications for sediment delivery
Authors: Daham Afrah , Sambrook Smith Gregory H , Nicholas Andrew P , Gasparotto Andrea , Clark Julian , Yasmin Tahmina 
Published: July 2024

Abstract
While issues of pollution, floods and drought in our rivers are widely studied, there is a hidden crisis with respect to the widespread global extraction of sand. Large volumes of sand are needed in the construction industry to make concrete. So far, calls for greater monitoring of sand mining activity have largely gone unmet. This is due to the fact mining is extensive, often hidden (e.g. underwater) and thus very difficult to properly assess. To meet this challenge, we use remote sensing methods to detect and monitor sand mining activities at the catchment scale, across the Ganges-Brahmaputra-Meghna River system (catchment size 1.72 million km2). Based on this analysis, here we show that mining activity is diverse and pervasive across the Ganges–Brahmaputra–Meghna Catchment system for our study period of 2016–2021, with rates of extraction increasing within some of the rivers. Results show the total estimate for sand extraction is ∼115 Mtyr−1 ± 20 Mtyr−1, which is of a similar order of magnitude to the natural bedload flux of the catchment. While there are some limitations to deriving estimates based solely on imagery, this work highlights both the widespread spatial extent and large magnitude of sand mining for one of the world’s biggest catchments. Furthermore, given our estimated scale of sand extraction, it demonstrates the need to properly account for mining activities when considering delivery of sediment to deltas in terms of the management of these vulnerable systems in the face of rising sea-levels. Overall, this work stresses the urgent requirement for further similar studies of sand extraction in the world’s large rivers, which is vital to underpin sustainable management plans for the global sand commons.
Providing feed containing fermented fish waste and phytogenic feed additive on the performance of male quail
Authors: Daud M , Zulfan  , Armia Y , Hasbaini  
Published: July 2024

Abstract
The purpose of this exploration was to determine the effect of using fermented fish waste and phytogenic feed additive in sections on the growth of male quail. The exploration material used was 1200 male quail progressed 1- day old quail (DOQ). The research method was carried out experimentally using a Completely Randomized Design (CRD) consisting of 4 treatments and 4 replications. The treatment rations used were as follows: R1 = control ration (without fermented1fish waste and phytogenic feed additive), R2 = feed1containing 10% fermented fish waste + 0.5%iphytogenic1feed additive, R3 = feed containing 15% fermented fish waste + 0.5% phytogenic feed additive, and R4 = feed containing 20% fermentedifish waste + 0.5% phytogenic feed additive. The variables1observed were: ration1consumption, feed conversion, body1weight gain,1final body1weight, and1mortality. The data obtained were analyzed1using analysis of variance (ANOVA) and followed by Duncan’s multiple1range test. The results of the study showed that the use of fermented fish waste and phytogenic feed additives in the ration had a significant1effect (p<0.05) on feed consumption, body weight1gain, final1body weight and ration conversion of 6-week-old male quail, but had no significant effect on mortality. The1results of the study concluded1that the use of fermented fish waste up to 20% and 0.5% phytogenic feed additive in the1ration did not have a negative effect1on the growth of male quail and could increase body weight gain and body weight of male quail aged 6 weeks.