bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN LKPD BERORIENTASI PENDEKATAN SAINTIFIK PADA MATERI SUHU DAN KALOR UNTUK MELATIHKAN KETERAMPILAN BERPIKIR KRITIS SISWA SMA
Authors: Oktarina Helda , Setiawan Iwan , Medriati Rosane 
Published: July 2024

ABSTRAK

Penelitian ini bertujuan untuk menghasilkan LKPD Berorientasi Pendekatan Saintifik pada materi suhu dan kalor untuk melatihkan keterampilan berpikir kritis siswa SMA. Metode yang digunakan dalam penelitian ini adalah metode R&D (Research and Development) dengan model pengembangan 4-D, namun pada penelitian ini dilakukan sampai tahp 3-D yang terdiri dari define, design, dan develop. Berdasarkan hasil validasi ahli pada aspek media diperoleh persentase sebesar 85% yang dikategorikan sangat layak, pada aspek materi diperoleh persentase sebesar 81,9% yang dikategorikan sangat layak, pada aspek bahasa diperoleh persentase sebesar 91,7% yang dikategorikan sangat layak. Sehingga, dapat disimpulkan bahwa LKPD Berorientasi Pendekatan Saintifik pada materi suhu dan kalor untuk melatihkan keterampilan berrpikir kritis siswa SMA berada pada kategori sangat layak dengan persentase rata-rata 86,2% dan hasil persepsi peserta didik dengan persentase rata-rata sebesar 86,06%.

Kata Kunci: LKPD, Pendekatan Saintifik, Keterampilan Berpikir Kritis.

ABSTRACT

This study aims to produce LKPD Oriented Scientific Approach on the material of temperature and heat to practice critical thinking skills of high school students. The method used in this study is the R&D (Research and Development) method with a 4-D development model, but in this study it was carried out to the 3-D stage consisting of define, design, and develop. Based on the results of expert validation on the media aspect, it was obtained a percentage of 85% which was categorized as very feasible, in the material aspect a percentage of 81.9% was obtained which was categorized as very feasible, in the language aspect a percentage of 91.7% was obtained which was categorized as very feasible. So, it can be concluded that the Scientific Approach Oriented LKPD on temperature and heat materials to train high school students' critical thinking skills is in the very feasible category with an average percentage of 86.2% and the students' perception results with an average percentage of 86.06%.

Keywords: LKPD, Scientific Approach, Critical Thinking Skills.
ANALISIS PELAKSANAAN PEMBELAJARAN IPA FISIKA SECARA DARING/ONLINE DI SMAN 3 SELUMA
Authors: Ananda Futri Dwi , Medriati Rosane , Purwanto Andik 
Published: July 2024

ABSTRAK

Penelitian ini bertujuan untuk (1) Mendeskripsikan perencanaan pembelajaran IPA fisika secara daring/online di SMAN 3 Seluma (2) Mendeskripsikan proses dan evaluasi pelaksanaan pembelajaran IPA fisika secara daring/online di SMAN 3 Seluma. Metode penelitian yang digunakan adalah metode penelitian deskriptif (descriptive research). Subjek penelitian adalah guru fisika dan IPA dan siswa kelas X serta XI IPA SMAN 3 Seluma. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah angket dan wawancara. Teknik analisis data pada penelitian ini yaitu dengan analisis data angket menggunakan rating scale dan analisis data hasil wawancara. Dari hasil pengolahan data diperoleh bahwa (1) Perencanaan pembelajaran IPA fisika secara daring/online di SMAN 3 Seluma berada pada kategori baik (2) Proses dan evaluasi pelaksanaan pembelajaran IPA fisika secara daring/online di SMAN 3 Seluma berada pada tingkat baik.

Kata Kunci : Pembelajaran daring, Pembelajaran IPA, Pembelajaran Fisika

ABSTRACT

The objective of this research was to (1) describe the online science learning plan at SMAN 3 Seluma (2) to describe the process and evaluation of the implementation of online science learning at SMAN 3 Seluma. The research method used is descriptive research method (descriptive research). The research subjects were physics and science teachers and students of class X and XI science at SMAN 3 Seluma. Data collection techniques used in this study were questionnaires and interviews. The data analysis technique in this study is by analyzing questionnaire data using a rating scale and analyzing data from interviews. From the results of data processing, it was obtained that (1) the online/online planning of physics science learning at SMAN 3 Seluma was in the good category (2) The process and evaluation of the implementation of online/online physics science learning at SMAN 3 Seluma was at a good level.

Keywords: online learning, science learning, physics learning
PENGEMBANGAN E-LKPD FISIKA BERBASIS PREDICT OBSERVE EXPLAIN (POE) PADA MATERI FLUIDA STATIS UNTUK MELATIH KEMAMPUAN BERPIKIR KRITIS SISWA SMA DI KOTA BENGKULU
Authors: Oktarina Amirah Sari , Hamdani Dedy , Purwanto Andik 
Published: July 2024

ABSTRAK

Penelitian ini bertujuan untuk mendeskripsikan kelayakan dan persepsi peserta didik terhadap Lembar Kerja Peserta Didik Elektronik (e-LKPD) berbasis Predict Observe Explain (POE) untuk melatihkan kemampuan berpikir kritis. Penelitian ini merupakan penelitian dan pengembangan (R&D) dengan model 3D dengan langkah-langkah define, design, dan develop. Teknik pengumpulan data yaitu teknik non tes yang menggunakan data observasi, review document, dan angket. Teknik analisis data yaitu dengan metode deskriptif, kualitatif, dan kuantitatif. Subjek yang digunakan pada penelitian ini adalah guru fisika dan peserta didik kelas XI di SMA Negeri 5, 7, dan 9 Kota Bengkulu. Hasil dari penelitian ini dapat disimpulkan bahwa e-LKPD berbasis POE untuk melatihkan kemampuan berpikir kritis yang dikembangkan termasuk dalam kriteria sangat layak dengan persentase rata-rata 95,06% sehingga layak diujicobakan serta mendapatkan persepsi sangat baik dari peserta didik dengan persentase rata-rata sebesar 85,69%.

Kata kunci: e-LKPD, POE, Kemampuan Berpikir Kritis.

ABSTRACT

This study aims to describe the feasibility and students' perceptions of the Predict Observe Explain (POE) based Electronic Student Worksheet (e-LKPD) to practice critical thinking skills. This research is a research and development (R&D) with a 3D model with the steps of define, design, and develop. Data collection techniques are non-test techniques that use observation data, document reviews, and questionnaires. Data analysis techniques are descriptive, qualitative, and quantitative methods. The subjects used in this study were physics teachers and class XI students at SMA Negeri 5, 7, and 9 Bengkulu City. The results of this study can be concluded that the POE-based e-LKPD to train critical thinking skills developed is included in the very feasible criteria with an average percentage of 95,06% so that it is worth trying out and getting very good perceptions from students with an average percentage of 85,69%.

Keywords: e-LKPD, POE, Critical Thinking Ability.
STUDI PENGELOLAAN EKOWISATA BERBASIS MASYARAKAT ADAT DI DESA SENARU KECAMATAN BAYAN KABUPATEN LOMBOK UTARA
Authors: Rachmansyah Deny , Nizar Wahyu Yuniati 
Published: July 2024

Ekowisata berbasis masyarakat merupakan usaha ekowisata yang menitik beratkan peran aktif komunikasi. Partisipasi masyarakat dalam pembangunan adalah keikutsertaan masyarakat baik dalam bentuk peryataan maupun kegiatan. keikutsertaan tersebut terbentuk sebagai akibat terjadinya interaksi sosial antara individu atau kelompok masyarakat di dalam pembangunan. Partisispasi masyarakat dalam berbagai bentuk seperti partisipasi dalam pembuatan keputusan, perencanaan, pelaksanaan, pemantauan dan evaluasi kegiatan serta pemanfaatan hasil pembangunan.Hasil penelitian menunjukan bahwa peran serta masyarakat dalam pengelolaan objek wisata Air Terjun Sendang Gila sangat tinggi, dikarenakan tingkat peran serta masyarakat baik pada saat rapat perencanaan, operasionalisasi serta pengawasan objek wisata Air Terjun Sendang Gila dinilai sangat aktif, disebabkan karena objek wisata Air Terjun Sendang Gila dimanafaatkan masyarakat selain untuk menambah pendapatan desa juga untuk menambah penghasilan masyarakat. Hal ini yang menyebabkan masyarakat berperan aktif dalam pengelolaan objek wisata Air Terjun Sendang Gila baik dalam rapat perencanaan, menata atau mendisain kawasan objek wisata, pembangunan Infrastruktur serta pengawasan - pengawasan yang menyangkut objek wisata.
Comparison of biomechanical effects of polyetheretherketone (PEEK) rods and titanium rods in lumbar long-segment instrumentation: a finite element study
Authors: Li Chao , Zhao Yao , Qi Longtao , Xu Beiyu , Yue Lei , Zhu Ranlyu , Li Chunde 
Published: July 2024

IntroductionPolyetheretherketone (PEEK) lumbar fusion rods have been successfully used in short-segment posterior instrumentation to prevent adjacent segment degeneration. However, limited studies have reported their application in lumbar long-segment instrumentation. This study aimed to compare the biomechanical performances of PEEK rods and titanium rods in lumbar long-segment instrumentation using finite element (FE) models, with the expectation of providing clinical guidance.MethodsA lumbar FE model (A) and four lumbar fixation FE models (BI, CI, BII, CII) of the L1–S1 vertebral body were developed using CT image segmentation (A: intact model; BI: intact model with L2–S1 PEEK rod internal fixation; CI: intact model with L2–S1 titanium rod internal fixation; BII: intact model with L3–S1 PEEK rod internal fixation; CII: intact model with L3–S1 titanium rod internal fixation). A 150-N preload was applied to the top surface of L1, similar to the intact model. The stresses on the lumbar intervertebral disc, facet joint, pedicle screws, and rods were calculated to evaluate the biomechanical effect of the different fixation procedures in lumbar long-segment instrumented surgery.ResultsUnder the four physiological motion states, the average stresses on the adjacent segment intervertebral disc and facet joint in all fixation models were greater than those in the intact model. Furthermore, the average stresses on the adjacent segment intervertebral disc and facet joint were greater in models CI and CII than in models BI and BII, respectively. The average stresses on the pedicle screws and rods were decreased in models BI and BII compared with models CI and CII under the four physiological motion states, respectively.DiscussionThe PEEK rod internal fixation system may have better biomechanical properties than the titanium rod internal fixation system in delaying adjacent segment degeneration, improving the lumbar function of postoperative patients, and reducing the risk of screw loosening and breakage in lumbar long-segment instrumentation.
Chia seed-mediated fabrication of ZnO/Ag/Ag2O nanocomposites: structural, antioxidant, anticancer, and wound healing studies
Authors: Rafique Aisha , Amjad Fatima , Janjua Muhammad Ramzan Saeed Ashraf , Naqvi Syed Ali Raza , Hassan Sadaf Ul , Abdullah Hanzla , Nazir Muhammad Shahid , Ali Zulfiqar , Alshihri Abdulaziz A. , Momenah Maha Abdullah , Mansour Adel Abo , Bajaber Majed A. , Alalwiat Ahlam A. 
Published: July 2024

Plant extract-mediated fabrication of metal nanocomposites is used in cell proliferation inhibition and topical wound treatment, demonstrating significant effectiveness. Salvia hispanica L. (chia) seed extract (CE) is used as the reaction medium for the green fabrication of ecofriendly ZnO(CE) nanoparticles (NPs) and Ag/Ag2O(CE) and ZnO/Ag/Ag2O(CE) nanocomposites. The resultant nanoparticles and nanocomposite materials were characterized using UV–visible, Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), X-ray diffraction (XRD), and energy-dispersive X-ray (EDX) techniques. In the context of antioxidant studies, ZnO/Ag/Ag2O(CE) exhibited 57% reducing power and 86% 2,2, diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging. All three materials showed strong antibacterial activity against Staphylococcus aureus (S. aureus), Escherichia coli (E.coli), and Bacillus subtilis (B. subtilis) bacterial strains. Additionally, ZnO(CE), Ag/Ag2O(CE), and ZnO/Ag/Ag2O(CE) also revealed 64.47%, 42.56%, and 75.27% in vitro Michigan Cancer Foundation-7 (MCF7) cancer cell line inhibition, respectively, at a concentration of 100 μg/mL. Selectively, the most effective composite material, ZnO/Ag/Ag2O(CE), was used to evaluate in vivo wound healing potential in rat models. The study revealed 96% wound closure in 10 days, which was quite rapid healing compared to wound healing using clinically available ointment. Therefore, in conclusion, the ZnO/Ag/Ag2O(CE) nanocomposite material could be considered for further testing and formulation as a good anticancer and wound healing agent.
Prognostic significance of soluble PD-L1 in prostate cancer
Authors: Zvirble Margarita , Survila Zilvinas , Bosas Paulius , Dobrovolskiene Neringa , Mlynska Agata , Zaleskis Gintaras , Jursenaite Jurgita , Characiejus Dainius , Pasukoniene Vita 
Published: July 2024

PurposeThe aim of this study was to assess the role of sPD-L1 and sPD-1 as potential biomarkers in prostate cancer (PCa). The association of the values of these soluble proteins were correlated to the clinical data: stage of disease, Gleason score, biochemical recurrence etc. For a comprehensive study, the relationship between sPD-L1 and sPD-1 and circulating immune cells was further investigated.Methods A total of 88 patients with pT2 and pT3 PCa diagnosis and 41 heathy men were enrolled. Soluble sPD-L1 and sPD-1 levels were measured in plasma by ELISA method. Immunophenotyping was performed by flow cytometry analysis.Results Our study’s findings demonstrate that PCa patients had higher levels of circulating sPD-L1 and sPD-1 comparing to healthy controls (p &lt; 0.001). We found a statistically significant (p &lt; 0.05) relationship between improved progression free survival and lower initial sPD-L1 values. Furthermore, patients with a lower sPD-1/sPD-L1 ratio were associated with a higher probability of disease progression (p &lt; 0.05). Additionally, a significant (p &lt; 0.05) association was discovered between higher Gleason scores and elevated preoperative sPD-L1 levels and between sPD-1 and advanced stage of disease (p &lt; 0.05). A strong correlation (p &lt; 0.05), between immunosuppressive CD4+CD25+FoxP3+ regulatory T cells and baseline sPD-L1 was observed in patients with unfavorable postoperative course of the disease, supporting the idea that these elements influence each other in cancer progression. In addition to the postoperative drop in circulating PD-L1, the inverse relationship (p &lt; 0.05), between the percentage of M-MDSC and sPD-L1 in patients with BCR suggests that M-MDSC is not a source of sPD-L1 in PCa patients.Conclusion Our findings suggest the potential of sPD-L1 as a promising prognostic marker in prostate cancer.
Determinants of anemia among patients receiving cancer chemotherapy in Northwest Ethiopia
Authors: Wondm Samuel Agegnew , Dagnew Samuel Berihun , Gubae Kale , Tesfaye Tegenu Chanie , Tamene Fasil Bayafers 
Published: July 2024

BackgroundChemotherapy-induced anemia (CIA) is a hematologic complication that frequently affects patients with cancer undergoing chemotherapy. It is associated with worse treatment outcomes, higher rates of morbidity and mortality, worse quality of life, and higher healthcare costs. The incidence and predictors of CIA in Ethiopia, particularly in Northwest Ethiopian oncology centers, are poorly understood. This study was conducted at Northwest Ethiopian oncology centers to evaluate the incidence and determinants of chemotherapy-induced anemia in adult patients with cancer undergoing chemotherapy.MethodsThis 3-year hospital-based retrospective follow-up study included adult patients with cancer receiving chemotherapy between 2019 and 2021 at two oncology centers in Northwest Ethiopia. Data were collected from October to December 2021. A binary logistic regression model was used to select variables and determine the Crude Odds Ratio (COR). Variables with P-value &lt; 0.2 were entered into the multivariable logistic regression and Adjusted odds ratio (AOR) with 95% Confidence intervals (CI) for variables with P-value &lt; 0.05 were estimated to show determinants of chemotherapy-induced anemia among cancer patients who received chemotherapy.ResultsA total of 402 patients were included in the final analysis. The overall incidence of CIA was 75.4% (95% CI 70.7, 79.8). Older age [AOR = 1.8, 95% CI (1.4–3.5); P = 0.043], hematologic cancer [AOR = 3.7, 95% CI (3.2–5.7), P = 0.021], obesity [AOR = 3.4, 95% CI (2.3–6.9); P = 0.028], ≥6 chemotherapy cycles [AOR = 3.8, 95% CI (3.2–5.1), P = 0.019], cancer metastasis to bone [AOR = 2.9, 95% CI (1.2–4.7), P = 0.025] were statistically significant predictors of chemotherapy-induced anemia.ConclusionChemotherapy-induced anemia persisted in a significant percentage of cancer patients. Chemotherapy-induced anemia developed in three-quarters of patients undergoing chemotherapy. Chemotherapy-induced anemia was significantly associated with older age, hematologic malignancy, obesity, a greater number of chemotherapy cycles, and cancer metastasis to bone. To lower the risk of morbidity related to anemia, patients with chemotherapy-induced anemia should be regularly evaluated and treated with appropriate treatment.
Mediation effect of gut microbiota on the relationship between physical activity and carotid plaque
Authors: Ouyang Wenbin , Tang Bei , He Yongmei , Wu Hao , Yang Pingting , Yin Lu , Li Xiaohui , Li Ying , Huang Xin 
Published: July 2024

BackgroundPhysical activity has been shown to have an effect on Carotid plaque (CP) which is a predictor of Cardiovascular disease (CVD). Studies have shown that physical activity can alter the composition of gut microbiota, whether its influence on CP was mediated by gut microbiota has yet to be proved.MethodsWe conducted a case–control study involving 30 CP patients and 31 controls. Logistic regression was used to analyze the association between CP and physical activity. LefSe was used to explore the association between gut microbiota and physical activity as well as CP, and PhyloMed was used to examine the mediating effect of gut microbiota in the association between physical activity and CP.ResultsAfter adjusting for potential confounders, adequate physical activity showed a significant association with a decreased risk of CP (ORadj: 0.25, 95%CI: 0.06, 0.97). CP was associated with enrichment in the order Bacteroidales within the phylum Bacteroidetes and the predominant microbiota in individuals without plaque was the order Clostridiales (LDA scores &gt;3). Individuals with adequate physical activity had a higher abundance of the order Clostridiales, while the order Bacteroidetes was enriched in individuals with inadequate physical activity (LDA scores &gt;3). The PhyloMed revealed a significant mediation effect of gut microbiota in the association between physical activity and CP (p = 0.03).ConclusionAdequate physical activity was significantly associated with a decreased risk of CP, and this association was mediated by an increase in the abundance of gut microbiota in the order Clostridiales.
Diagnostic potential of IL6 and other blood-based inflammatory biomarkers in mild traumatic brain injury among children
Authors: Chiollaz Anne-Cécile , Pouillard Virginie , Habre Céline , Seiler Michelle , Romano Fabrizio , Spigariol Fabian , Ritter Schenk Céline , Korff Christian , Maréchal Fabienne , Wyss Verena , Gruaz Lyssia , Montaner Joan , Manzano Sergio , Sanchez Jean-Charles 
Published: July 2024

ObjectivesInflammatory biomarkers, as indicators of biological states, provide a valuable approach for accurate and reproducible measurements, crucial for the effective management of mild traumatic brain injury (mTBI) in pediatric patients. This study aims to assess the diagnostic utility of blood-based inflammatory markers IL6, IL8, and IL10 in children with mTBI, including those who did not undergo computed tomography (CT) scans.MethodsA prospective multicentric cohort study involving 285 pediatric mTBI patients was conducted, stratified into CT-scanned and non-CT-scanned groups within 24 h post-trauma, alongside 74 control subjects. Biomarker levels were quantitatively analyzed using ELISA. Sensitivity and specificity metrics were calculated to determine the diagnostic efficacy of each biomarker.ResultsA total of 223 mTBI patients (78%) did not undergo CT scan examination but were kept in observation for symptoms monitoring at the emergency department (ED) for more than 6 h (in-hospital-observation patients). Among CT-scanned patients (n = 62), 14 (23%) were positive (CT+). Elevated levels of IL6 and IL10 were found in mTBI children compared to controls. Within mTBI patients, IL6 was significantly increased in CT+ patients compared to both CT– and in-hospital-observation patients. No significant differences were observed for IL8 among the compared groups. IL6 yielded a specificity of 48% in identifying CT– and in-hospital-observation patients, with 100% sensitivity in excluding all CT+ cases. These performances were maintained whether IL6 was measured within 6 h or within 24 h after the trauma.ConclusionThe inflammatory marker IL6 emerges as a robust biomarker, showing promising stratification value for pediatric mTBI patients undergoing CT scans or staying in observation in a pediatric ED.
Case report: Pathological complete response to neoadjuvant brigatinib in stage III non-small cell lung cancer with ALK rearrangement
Authors: Seong Hayoung , Kim Soo Han , Kim Mi Hyun , Cho Jeong Su , Kim Ahrong , Eom Jung Seop 
Published: July 2024

PurposeThe use of neoadjuvant anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors (TKIs) has not been extensively explored. The current case report highlights the notable pathological complete response (pCR) achieved following neoadjuvant brigatinib therapy in a patient with stage IIIA ALK-positive non-small cell lung cancer (NSCLC).Case presentationA 32-year-old male presented with incidental lung lesions, ultimately diagnosed as clinical stage T3N1M0, IIIA NSCLC with an ALK gene rearrangement. Following a multidisciplinary discussion, the patient opted for neoadjuvant brigatinib therapy, which significantly reduced the tumor size. Subsequently, surgery with curative intent was performed, revealing pCR with no residual tumor cells. The patient remained disease-free during a 13-month follow-up period.ConclusionThis case report provides compelling evidence of pCR following brigatinib therapy in ALK-positive NSCLC, suggesting that surgery after neoadjuvant therapy with brigatinib may offer a safe and effective approach for patients with ALK-positive NSCLC.