bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Delivery of Bright Futures Preventive Services at the 9- and 24-Month Well Child Visit
Authors: Duncan Paula M. , Pirretti Amy , Earls Marian F. , Stratbucker William , Healy Jill A. , Shaw Judith S. , Kairys Steven 
Published: December 2014

OBJECTIVES:
To determine if clinicians and staff from 21 diverse primary care practice settings could implement the 2008 Bright Futures Guidelines for Health Supervision of Infants, Children, and Adolescents, 3rd edition recommendations, at the 9- and 24-month preventive services visits.

METHODS:
Twenty-two practice settings from 15 states were selected from 51 applicants to participate in the Preventive Services Improvement Project (PreSIP). Practices participated in a 9-month modified Breakthrough Series Collaborative from January to November 2011. Outcome measures reflect whether the 17 components of Bright Futures recommendations were performed at the 9- and 24-month visits for at least 85% of visits. Additional measures identified which office systems were in place before and after the collaborative.

RESULTS:
There was a statistically significant increase for all 17 measures. Overall participating practices achieved an 85% completion rate for the preventive services measures except for discussion of parental strengths, which was reported in 70% of the charts. The preventive services score, a summary score for all the chart audit measures, increased significantly for both the 9-month (7 measures) and 24-month visits (8 measures).

CONCLUSIONS:
Clinicians and staff from various practice settings were able to implement the majority of the Bright Futures recommended preventive services at the 9- and 24-month visits at a high level after participation in a 9-month modified Breakthrough Series collaborative.
Telemedicine for Evaluation of Retinopathy of Prematurity
Authors: Fierson Walter M. , Capone Antonio ,   the AMERICAN ACADEMY OF PEDIATRICS SECTION ON OPHTHALMOLOGY, AMERICAN ACADEMY OF OPHTHALMOLOGY, and AMERICAN ASSOCIATION OF CERTIFIED ORTHOPTISTS, Granet David B. , Blocker Richard J. , Bradford Geoffrey E. , Lehman FAAP. Sharon S. , Rubin Steven E. , Siatkowski R. Michael , Ruben James B. 
Published: December 2014

This Technical Report was reaffirmed February 2021.
Retinopathy of prematurity (ROP) remains a significant threat to vision for extremely premature infants despite the availability of therapeutic modalities capable, in most cases, of managing this disorder. It has been shown in many controlled trials that application of therapies at the appropriate time is essential to successful outcomes in premature infants affected by ROP. Bedside binocular indirect ophthalmoscopy has been the standard technique for diagnosis and monitoring of ROP in these patients. However, implementation of routine use of this screening method for at-risk premature infants has presented challenges within our existing care systems, including relative local scarcity of qualified ophthalmologist examiners in some locations and the remote location of some NICUs. Modern technology, including the development of wide-angle ocular digital fundus photography, coupled with the ability to send digital images electronically to remote locations, has led to the development of telemedicine-based remote digital fundus imaging (RDFI-TM) evaluation techniques. These techniques have the potential to allow the diagnosis and monitoring of ROP to occur in lieu of the necessity for some repeated on-site examinations in NICUs. This report reviews the currently available literature on RDFI-TM evaluations for ROP and outlines pertinent practical and risk management considerations that should be used when including RDFI-TM in any new or existing ROP care structure.
Use of Electronic Health Record Systems by Office-Based Pediatricians
Authors: Lehmann Christoph U. , O’Connor Karen G. , Shorte Vanessa A. , Johnson Timothy D. 
Published: December 2014

BACKGROUND AND OBJECTIVES:
The American Recovery and Reinvestment Act of 2009 accelerated the implementation of electronic health records (EHRs) in pediatric offices. We sought to determine the prevalence and functionalities of EHRs, as well as pediatricians’ perceptions of EHRs.

METHODS:
An 8-page self-administered questionnaire was sent randomly to 1621 nonretired US members of the American Academy of Pediatrics from July to December 2012. Responses were compared with a similar survey in 2009.

RESULTS:
The percent of pediatricians, who are using EHRs, increased significantly from 58% in the 2009 survey to 79% in 2012. Only 31% used an EHR considered to have basic functionality, and only 14% used a fully functional EHR. Providers with equal or greater than 20% public insurance patients (threshold for meaningful use eligibility) were more likely to have an EHR. Solo/2-physician practices were least likely to have adopted an EHR. Younger physicians were more likely to consider an EHR important to quality care and perceived the presence of an EHR as more important in recruiting.

CONCLUSIONS:
The number of office-based pediatricians who are using an EHR has steadily risen to almost 80%. EHR cost and reduction in productivity remain serious concerns. Despite the widespread adoption of EHRs by pediatricians, only few use a basic or fully functional EHR and even fewer have added pediatric functionality. There is a role for the EHR certification process to advance functionalities used by pediatricians and to increase efficiency, data exchange capability, and general EHR functionality.
Early Childhood Neurodevelopment After Intrauterine Growth Restriction: A Systematic Review
Authors: Levine Terri A. , Grunau Ruth E. , McAuliffe Fionnuala M. , Pinnamaneni RagaMallika , Foran Adrienne , Alderdice Fiona A. 
Published: December 2014

BACKGROUND AND OBJECTIVE:Children who experienced intrauterine growth restriction (IUGR) may be at increased risk for adverse developmental outcomes in early childhood. The objective of this study was to carry out a systematic review of neurodevelopmental outcomes from 6 months to 3 years after IUGR.METHODS:PubMed, Embase, PsycINFO, Maternity and Infant Care, and CINAHL databases were searched by using the search terms intrauterine, fetal, growth restriction, child development, neurodevelopment, early childhood, cognitive, motor, speech, language. Studies were eligible for inclusion if participants met specified criteria for growth restriction, follow-up was conducted within 6 months to 3 years, methods were adequately described, non-IUGR comparison groups were included, and full English text of the article was available. A specifically designed data extraction form was used. The methodological quality of included studies was assessed using well-documented quality-appraisal guidelines.RESULTS:Of 731 studies reviewed, 16 were included. Poorer neurodevelopmental outcomes after IUGR were described in 11. Ten found motor, 8 cognitive, and 7 language delays. Other delays included social development, attention, and adaptive behavior. Only 8 included abnormal Doppler parameters in their definitions of IUGR.CONCLUSIONS:Evidence suggests that children are at risk for poorer neurodevelopmental outcomes following IUGR from 6 months to 3 years of age. The heterogeneity of primary outcomes, assessment measures, adjustment for confounding variables, and definitions of IUGR limits synthesis and interpretation. Sample sizes in most studies were small, and some examined preterm IUGR children without including term IUGR or AGA comparison groups, limiting the value of extant studies.
Best Practices for Improving Flow and Care of Pediatric Patients in the Emergency Department
Authors: Barata Isabel , Brown Kathleen M. , Fitzmaurice Laura , Griffin Elizabeth Stone , Snow Sally K. ,   American Academy of Pediatrics Committee on Pediatric Emergency Medicine,   American College of Emergency Physicians Pediatric Emergency Medicine Committee,   Emergency Nurses Association Pediatric Committee, Shook Joan E. , Ackerman Alice D. , Chun Thomas H. , Conners Gregory P. , Dudley Nanette C. , Fuchs Susan M. , Gorelick Marc H. , Lane Natalie E. , Moore Brian R. , Wright Joseph L. , Benjamin Lee S. , Alade Kiyetta , Arms Joseph , Avarello Jahn T. , Baldwin Steven , Cantor Richard M. , Cohen Ariel , Dietrich Ann Marie , Eakin Paul J. , Gausche-Hill Marianne , Gerardi Michael , Graham Charles J. , Holtzman Doug K. , Hom Jeffrey , Ishimine Paul , Jinivizian Hasmig , Joseph Madeline , Mehta Sanjay , Ojo Aderonke , Paul Audrey Z. , Pauze Denis R. , Pearson Nadia M. , Rosen Brett , Russell W. Scott , Saidinejad Mohsen , Sloas Harold A. , Schwartz Gerald R. , Swenson Orel , Valente Jonathan H. , Waseem Muhammad , Whiteman Paula J. , Woolridge Dale , Vicioso Michael , Herrin Shari A , Nagle Jason T. , Cadwell Sue M. , Goodman Robin L. , Johnson Mindi L. , Frankenberger Warren D. 
Published: December 2014

This Technical Report was reaffirmed July 2020.
This report provides a summary of best practices for improving flow, reducing waiting times, and improving the quality of care of pediatric patients in the emergency department.
Reflections from the Process of Game-Based Teaching of Probability/Prikazi procesa poučavanja vjerojatnosti posredstvom igre
Authors: Gürbüz Ramazan , Erdem Emrullah , Uluat Bedrettin 
Published: December 2014

AbstractThe aim of this study is to determine what happens when the subject of probability is taught via educational games. Participants in the research were fourth-grade students (N= 24, aged 9-10) who were taught for 3 class hours (each 40 minutes) by their teacher. The designed games were played among groups of 3-4 students. Data was gathered from 8 selected students’ responses to semi-structured interviews, the teacher’s views about the process, researchers’ evaluations of students’ reflections, students’ journal entries regarding the process, and audio and video recordings of students’ interactions. The findings were presented according to data collection sources. Evidence suggested that game-based teaching facilitated understanding, enhanced students’ participation and motivation, enabled them to work with peers, helped them overcome math anxiety, provided an amusing learning environment, although it also resulted in classroom management difficulty and a noisy learning environment. Key words: cooperative learning; game-based teaching; mathematics education; opinions of teacher and students; probability. --- SažetakCilj istraživanja bio je odrediti što će se dogoditi kada vjerojatnost poučavamo posredstvom obrazovne igre. Sudionici istraživanja bili su učenici četvrtog razreda (N= 24, dob 9-10) koji su imali tri nastavna sata (u trajanju od 40 minuta) i njihov učitelj. Odabrane igre provodile su se u skupinama od 3 do 4 učenika. Podaci su dobiveni na temelju odgovora osam učenika u polustrukturiranom intervjuu, stavova učitelja o procesu, istraživačke procjene učeničkih razmatranja, učeničkih bilješki u dnevnicima vezanim uz proces, kao i na temelju audio i video zapisa interakcije učenika. Nalazi su prikazani prema načinu prikupljanja podataka. Dokazi ukazuju na to da učenje posredstvom igre potiče razumijevanje, poboljšava sudjelovanje učenika i motivaciju, omogućuje zajednički rad s djecom, pomaže u suzbijanju straha od matematike, stvara zabavno okruženje za učenje, ali kao posljedicu ima poroblem vladanja razredom i prilično bučnu atmosferu za učenje. Ključne riječi: suradničko učenje; učenje posredstvom igre; matematika; stavovi učitelja i učenika; vjerojatnost.
AComparing ’Ex catedra’ and IT-Supported Teaching Methods and Techniques: Policy of Teaching Practice/Usporedba ex catedra i računalno potpomognutih metoda i tehnika poučavanja: politika nastavne prakse
Authors: Dobrota Marina , Benković Slađana 
Published: December 2014

AbstractTeaching at higher education institutions in Serbia still relies on traditional ‘ex catedra’ methods and is mostly based on acquiring factual knowledge, which discourages student participation in the learning process, as well as any initiative on their part. The aim of the paper is to point to the implementation of the traditional ‘ex catedra’ versus the use of IT-supported teaching methods and techniques. The underlying idea is that professors’ abilities depend on their familiarity with different teaching methods and techniques, their knowledge of a foreign language, and the use of ICT. The data analysis has confirmed that teachers do differ from each other with respect to their academic titles: senior teachers (associate and full professors) use traditional methods more frequently than younger teachers do. In general, all teachers should incorporate modern trends into their teaching styles, since traditional teaching methods and techniques are used more often than IT-supported ones.Key words: IT-supported teaching; teaching methods; teaching techniques; traditional ‘ex catedra’ teaching; universities in Serbia---SažetakNa visokoškolskim institucijama u Srbiji poučavanje se još uvijek oslanja na tradicionalne ex catedra metode, većinom se temelji na usvajanju činjeničnoga znanja, čime se studenti obeshrabruju od sudjelovanja u procesu učenja i poduzimanja inicijative. Cilj ovoga rada jest uputiti na upotrebu tradicionalnog ex catedra poučavanja u usporedbi s računalno potpomognutim metodama i tehnikama poučavanja. Smatra se da sposobnosti nastavnika ovise o njihovu poznavanju različitih metoda i tehnika poučavanja, znanja stranoga jezika i upotrebe informacijsko-komunikacijskih tehnologija. Analiza rezultata potvrdila je da se nastavnici međusobno razlikuju s obzirom na akademska zvanja: iskusniji nastavnici (izvanredni i redoviti profesori) češće se koriste tradicionalnim metodama od njihovih mlađih kolega. Općenito, svi bi nastavnici trebali uključiti moderne trendove u svoje stilove poučavanja, s obzirom na to da se tradicionalne metode i tehnike koriste češće od onih računalno potpomognutih.Ključne riječi: metode poučavanja; računalno potpomognuto poučavanje; sveučilišta u Srbiji; tehnike poučavanja; tradicionalno ex catedra poučavanje.
Levelized Product Cost: Concept and Decision Relevance
Authors: Reichelstein Stefan , Rohlfing-Bastian Anna 
Published: December 2014

ABSTRACT
We examine a life-cycle cost concept that applies to both manufacturing and service industries in which upfront capacity investments are essential. Borrowing from the energy literature, we refer to this cost measure as the Levelized Product Cost (LC). Per unit of output, the levelized cost aggregates a share of the initial capacity investment with periodic fixed and variable operating costs. We relate this cost measure to the notion of full cost, as commonly calculated in managerial accounting texts. Our analysis identifies conditions under which the LC can be interpreted as the long-run marginal product cost. In particular, the LC is the relevant unit cost that firms should impute for investments in productive capacity.
The Value and Credit Relevance of Multiemployer Pension Plan Obligations
Authors: Chen Ting , Martin Xiumin , Mashruwala Christina A. , Mashruwala Shamin D. 
Published: December 2014

ABSTRACT
We investigate whether multiemployer defined-benefit pension plan (MEPP) underfunding is priced by shareholders and creditors. Prior to the FASB's new MEPP standard (effective December 2011), when the disclosures on such plans were sparse, we find evidence (some evidence) that our estimate of a firm's share of MEPP underfunding is credit (value) relevant. We also find some evidence that a proxy for the funded status of a firm's MEPPs is incrementally value relevant over and above the firm's cash contributions, but no evidence that it is credit relevant. Furthermore, an estimate of MEPP underfunding that incorporates the additional disclosures required under the new MEPP standard is value and credit relevant, both individually and incrementally, over and above our old estimate. Overall, our findings suggest that shareholders and creditors view MEPP underfunding as a debt-like obligation and that the additional MEPP disclosures under the new standard are useful to market participants.
Information Complementarities and Supply Chain Analysts
Authors: Luo Shuqing , Nagarajan Nandu J. 
Published: December 2014

ABSTRACT
This study examines the antecedents and consequences of analysts choosing to become supply chain analysts (i.e., analysts following both a supplier and its major customer). We find that information complementarities between firms in the same supply chain, between a supplier firm and its industry peer firms, and between the supplier's major customer and other firms in analysts' portfolio affect their supply chain specialization decision. The potential revenues supplier firms generate for analysts' brokerage houses also significantly affect this decision. While supply chain analysts achieve superior forecast performance compared to non-supply chain analysts for supplier firms, they provide lower-quality forecasts for other firms in their portfolios. These findings suggest that analysts allocate resources strategically. Our results are robust to techniques designed to address the potential endogeneity of analysts' supply chain portfolio choices.
Auswirkungen der Douglasie auf die Waldbiodiversität
Authors: Tschopp Tobias , Holderegger Rolf , Bollmann Kurt 
Published: December 2014

Effects of Douglas fir on forest biodiversity
Under climate change, forestry in Switzerland promotes the increased cultivation of exotic Douglas fir (Pseudotsuga menziesii), as Douglas fir is more drought-resistant than native spruce. However, nature conservation organisations fear that enhanced planting of Douglas fir will negatively affect biodiversity and that Douglas fir has invasive potential. Based on the existing scientific and grey literature, we compile the present knowledge on the effects on forest habitats and biodiversity and the invasiveness of Douglas fir in Central Europe. The cultivation of Douglas fir does not seem to have any additional negative effects on soils as compared to native conifers, and its effects on biodiversity are diverse and often inconsistent. Overall, there is often a shift in species composition and in the dominance ratio for most studied groups of organisms (e.g. fungi, plants, arthropods, birds) in Douglas fir stands. Although natural regeneration of Douglas fir does occur in many regions of Central Europe, its extent, site-specificity and frequency and, therefore, the invasiveness of Douglas fir are not yet clear. We identified the following knowledge gaps: 1) Douglas fir should be studied along mixture gradients with other tree species, especially beech, in order to determine threshold values at which negative effects of biodiversity begin to appear. 2) The effects of Douglas fir on Red List, priority or characteristic forest species have not yet been thoroughly evaluated. 3) Frequency of natural regeneration and dispersal potential of Douglas fir in Central Europe should be assessed. Filling these knowledge gaps will allow a more reliable and integral assessment of the biodiversity effects of Douglas fir and its invasive potential.
Effector T Cells Boost Regulatory T Cell Expansion by IL-2, TNF, OX40, and Plasmacytoid Dendritic Cells Depending on the Immune Context
Authors: Baeyens Audrey , Saadoun David , Billiard Fabienne , Rouers Angéline , Grégoire Sylvie , Zaragoza Bruno , Grinberg-Bleyer Yenkel , Marodon Gilles , Piaggio Eliane , Salomon Benoît L. 
Published: December 2014

Abstract
CD4+CD25+Foxp3+ regulatory T (Treg) cells play a major role in peripheral tolerance. Multiple environmental factors and cell types affect their biology. Among them, activated effector CD4+ T cells can boost Treg cell expansion through TNF or IL-2. In this study, we further characterized this effector T (Teff) cell–dependent Treg cell boost in vivo in mice. This phenomenon was observed when both Treg and Teff cells were activated by their cognate Ag, with the latter being the same or different. Also, when Treg cells highly proliferated on their own, there was no additional Treg cell boost by Teff cells. In a condition of low inflammation, the Teff cell–mediated Treg cell boost involved TNF, OX40L, and plasmacytoid dendritic cells, whereas in a condition of high inflammation, it involved TNF and IL-2. Thus, this feedback mechanism in which Treg cells are highly activated by their Teff cell counterparts depends on the immune context for its effectiveness and mechanism. This Teff cell–dependent Treg cell boost may be crucial to limit inflammatory and autoimmune responses.
IFN-γ Production by Memory Helper T Cells Is Required for CD40-Independent Alloantibody Responses
Authors: Gorbacheva Victoria , Fan Ran , Wang Xi , Baldwin William M. , Fairchild Robert L. , Valujskikh Anna 
Published: December 2014

Abstract
Cognate T–B cell interactions and CD40–CD154 costimulation are essential for productive humoral immunity against T-dependent Ags. We reported that memory CD4 T cells can deliver help to B cells and induce pathogenic IgG alloantibodies in the absence of CD40–CD154 interactions. To determine cytokine requirements for CD40-independent help, we used CD40−/− mice containing differentiated subsets of donor-reactive memory Th cells as heart allograft recipients. Th1 and Th17, but not Th2, memory CD4 T cells elicited high titers of anti-donor Ab. Abs induced by Th17 memory CD4 T cells had decreased reactivity against donor MHC class I molecules and inferior ability to cause complement deposition in heart allografts compared with Abs induced by Th1 cells, suggesting a requirement for IFN-γ during CD40-independent help. IFN-γ neutralization inhibited helper functions of memory CD4 T cells in both CD40−/− recipients and wild type recipients treated with anti-CD154 mAb. Our results suggest that IFN-γ secreted by pre-existing memory helper cells determines both isotype and specificity of donor-reactive alloantibodies and can thus affect allograft pathology. This information may be valuable for identifying transplant patients at risk for de novo development of pathogenic alloantibodies and for preventing alloantibody production in T cell–sensitized recipients.
Antibody-Mediated Trapping of Helminth Larvae Requires CD11b and Fcγ Receptor I
Authors: Esser-von Bieren Julia , Volpe Beatrice , Kulagin Manuel , Sutherland Duncan B. , Guiet Romain , Seitz Arne , Marsland Benjamin J. , Verbeek J. Sjef , Harris Nicola L. 
Published: December 2014

Abstract
Infections with intestinal helminths severely impact on human and veterinary health, particularly through the damage that these large parasites inflict when migrating through host tissues. Host immunity often targets the motility of tissue-migrating helminth larvae, which ideally should be mimicked by anti-helminth vaccines. However, the mechanisms of larval trapping are still poorly defined. We have recently reported an important role for Abs in the rapid trapping of tissue-migrating larvae of the murine parasite Heligmosomoides polygyrus bakeri. Trapping was mediated by macrophages (MΦ) and involved complement, activating FcRs, and Arginase-1 (Arg1) activity. However, the receptors and Ab isotypes responsible for MΦ adherence and Arg1 induction remained unclear. Using an in vitro coculture assay of H. polygyrus bakeri larvae and bone marrow–derived MΦ, we now identify CD11b as the major complement receptor mediating MΦ adherence to the larval surface. However, larval immobilization was largely independent of CD11b and instead required the activating IgG receptor FcγRI (CD64) both in vitro and during challenge H. polygyrus bakeri infection in vivo. FcγRI signaling also contributed to the upregulation of MΦ Arg1 expression in vitro and in vivo. Finally, IgG2a/c was the major IgG subtype from early immune serum bound by FcγRI on the MΦ surface, and purified IgG2c could trigger larval immobilization and Arg1 expression in MΦ in vitro. Our findings reveal a novel role for IgG2a/c-FcγRI–driven MΦ activation in the efficient trapping of tissue-migrating helminth larvae and thus provide important mechanistic insights vital for anti-helminth vaccine development.