bluuebunny/crossref_metadata_2025_split huggingface dataset:
Special Chiral C2‐Symmetric endo‐Biarylnorbornane: Synthesis and Structure Illustration
Authors: Cai Chonglin , Chen Ruigang , He Jun , Feng Juntao , Zhang Xing 
Published: July 2014

AbstractA highly efficient and practical synthesis for strained special scaffold of chiral endo‐biarylnorbornane starting from available norbornadione was achieved with direct stereoselective dehydroxylation of tertiary alcohol as the key step, and the structure was illustrated by X‐ray structural analysis.
Metal‐Organic Gels Based on Carboxyl‐Functionalized Benzimidazole and Their Stimuli Responsivenesses
Authors: Yao Hong , You Xingmei , Lin Qi , Wu Hongping , Wei Taibao , Zhang Youming 
Published: July 2014

AbstractThree multi‐responsiveness supramolecular metal‐organic gels (MOGs) have been prepared upon Ba(OAc)2, CdSO4·8H2O and Pb(NO3)2 with a simple ligand (G17) based on a carboxyl‐functionalized benzimidazole derivative in alcoholic‐water solutions. The MOGs display the formation of well‐developed nanofibrillar networks composed of intertwined fibers which provide stability to gels structures through coordination, hydrogen bonding and π‐ π interactions characterized by using field emission scanning electron microscopy (FESEM), the fourier transform infrared (FT‐IR) spectroscopy and powder X‐ray diffraction (XRD) techniques. MOG‐1 shows good stimuli responsiveness toward the changes in K2CrO4, both MOG‐2 and MOG‐3 do good job toward the changes in Na2S. Moreover, because these MOGs were formed easily by gelator with some heavy metal ion, such as Cd(II) and Pb(II), it might provide the basis for heavy metal ion capture and removal.
Adsorption Mechanism of Acetylene Hydrogenation
Authors: Xie Xuejia , Song Xiuli , Dong Wenyan , Liang Zhenhai , Fan Caimei , Han Peide 
Published: July 2014

AbstractFirst‐principles calculations are carried out to examine the adsorption of acetylene over the Pd (111) surface. A hydrogen adsorption system is initially investigated to confirm the reliability of the selected calculation method. Adsorption energies, Mulliken‐populations, overlap populations, charge density, and projected density of states (PDOS) are then calculated in the optimised acetylene adsorption system. Results show that C2H2 molecule tends to adsorb through the threefold parallel‐bridge configuration that is computed to be the most stable. In this structure, the distance of the CH bond is calculated to be 1.09 Å, and the C‐C‐H bond angle is 128°. The distance of the CC bond in acetylene is 1.36 Å, increasing from 1.21 Å in the gas phase. Moreover, the CC bond overlap population decreases from 1.98 to 1.38, revealing that the carbon configuration in C2H2 rehybridises from sp to sp2 and beyond. The obtained results are compared with available experimental studies on acetylene hydrogenation on single‐metal surfaces. The PDOS study indicates that a carbonaceous layer may generate on the metal surface during acetylene adsorption. The carbonaceous layer can affect the adsorption and reaction of acetylene, thereby inactivating the metal surface. Our experiments also show that Pd exhibits high catalytic activity.
Ordered Ultrathin Films of Perylene Anions and Layered Double Hydroxide Using Exfoliation‐coassembly Method
Authors: Zhang Yingkui , Song Ming , Yun Rongping , Meng Qingyun , Yan Dongpeng 
Published: July 2014

AbstractRecently, the fabrication of ordered luminescent ultrathin film (UTF) materials based on layered double hydroxides (LDHs) has received much attention. However, how to obtain these UTFs assembled by small anions and LDHs nanosheets is still a challenge. Herein, perylene 3,4,9,10‐tetracarboxylate (PTCB) was firstly chosen as the anion with the aim to obtain PTCB/LDH UTFs, which cannot be formed based on typical layer‐by‐layer (LBL) method. Then, the polymer anions (such as poly 4‐styrene sulfonate (PSS) and poly vinyl sulfonate (PVS)) were further chosen as the co‐assembled units with PTCB, which can act as carriers to assemble with LDH nanosheets. The as‐obtained PTCB@PSS/LDH and PTCB@PVS/LDH UTFs present long range ordered structures confirmed by powder X‐ray diffraction (XRD), scanning electron microscopy (SEM) and atomic force microscopy (AFM). Moreover, these two UTF systems show polarized luminescence with the emissive anisotropy of ca. 0.62 and 0.73. Therefore, this work presents an exfoliation‐coassembly way to develop LDH‐based ordered luminescent films, which may benefit their future optical display applications.
Absolute counting of neutrophils in whole blood using flow cytometry
Authors: Brunck Marion E. G. , Andersen Stacey B. , Timmins Nicholas E. , Osborne Geoffrey W. , Nielsen Lars K. 
Published: July 2014

AbstractAbsolute neutrophil count (ANC) is used clinically to monitor physiological dysfunctions such as myelosuppression or infection. In the research laboratory, ANC is a valuable measure to monitor the evolution of a wide range of disease states in disease models. Flow cytometry (FCM) is a fast, widely used approach to confidently identify thousands of cells within minutes. FCM can be optimised for absolute counting using spiked‐in beads or by measuring the sample volume analysed. Here we combine the 1A8 antibody, specific for the mouse granulocyte protein Ly6G, with flow cytometric counting in straightforward FCM assays for mouse ANC, easily implementable in the research laboratory. Volumetric and Trucount™ bead assays were optimized for mouse neutrophils, and ANC values obtained with these protocols were compared to ANC measured by a dual‐platform assay using the Orphee Mythic 18 veterinary haematology analyser. The single platform assays were more precise with decreased intra‐assay variability compared with ANC obtained using the dual protocol. Defining ANC based on Ly6G expression produces a 15% higher estimate than the dual protocol. Allowing for this difference in ANC definition, the flow cytometry counting assays using Ly6G can be used reliably in the research laboratory to quantify mouse ANC from a small volume of blood. We demonstrate the utility of the volumetric protocol in a time‐course study of chemotherapy induced neutropenia using four drug regimens. © 2014 International Society for Advancement of Cytometry
Ontogeny of object versus location recognition in the rat: Acquisition and retention effects
Authors: Westbrook Sara R. , Brennan Lauren E. , Stanton Mark E. 
Published: July 2014

ABSTRACTNovel object and location recognition tasks harness the rat's natural tendency to explore novelty (Berlyne, 1950) to study incidental learning. The present study examined the ontogenetic profile of these two tasks and retention of spatial learning between postnatal day (PD) 17 and 31. Experiment 1 showed that rats ages PD17, 21, and 26 recognize novel objects, but only PD21 and PD26 rats recognize a novel location of a familiar object. These results suggest that novel object recognition develops before PD17, while object location recognition emerges between PD17 and PD21. Experiment 2 studied the ontogenetic profile of object location memory retention in PD21, 26, and 31 rats. PD26 and PD31 rats retained the object location memory for both 10‐min and 24‐hr delays. PD21 rats failed to retain the object location memory for the 24‐hr delay, suggesting differential development of short‐ versus long‐term memory in the ontogeny of object location memory. © 2014 Wiley Periodicals, Inc. Dev Psychobiol 56: 1492–1506, 2014.
Climatic, ecophysiological, and phenological controls on plant ecohydrological strategies in seasonally dry ecosystems
Authors: Vico Giulia , Thompson Sally E. , Manzoni Stefano , Molini Annalisa , Albertson John D. , Almeida‐Cortez Jarcilene S. , Fay Philip A. , Feng Xue , Guswa Andrew J. , Liu Hu , Wilson Tiffany G. , Porporato Amilcare 
Published: July 2014

AbstractLarge areas in the tropics and at mid‐latitudes experience pronounced seasonality and inter‐annual variability in rainfall and hence water availability. Despite the importance of these seasonally dry ecosystems (SDEs) for the global carbon cycling and in providing ecosystem services, a unifying ecohydrological framework to interpret the effects of climatic variability on SDEs is still lacking. A synthesis of existing data about plant functional adaptations in SDEs, covering some 400 species, shows that leaf phenological variations, rather than physiological traits, provide the dominant control on plant‐water‐carbon interactions. Motivated by this result, the combined implications of leaf phenology and climatic variability on plant water use strategies are here explored with a minimalist model of the coupled soil water and plant carbon balances. The analyses are extended to five locations with different hydroclimatic forcing, spanning seasonally dry tropical climates (without temperature seasonality) and Mediterranean climates (exhibiting out of phase seasonal patterns of rainfall and temperature). The most beneficial leaf phenology in terms of carbon uptake depends on the climatic regime: evergreen species are favoured by short dry seasons or access to persistent water stores, whereas high inter‐annual variability of rainy season duration favours the coexistence of multiple drought‐deciduous phenological strategies. We conclude that drought‐deciduousness may provide a competitive advantage in face of predicted declines in rainfall totals, while reduced seasonality and access to deep water stores may favour evergreen species. This article has been contributed to by US Government employees and their work is in the public domain in the USA.
Food Addiction and Bulimia Nervosa
Authors: Meule Adrian , von Rezori Vittoria , Blechert Jens 
Published: July 2014

AbstractIn individuals with obesity and binge eating disorder (BED), eating patterns can show addictive qualities, with similarities to substance use disorders on behavioural and neurobiological levels. Bulimia nervosa (BN) has received less attention in this regard, despite their regular binge eating symptoms. The Yale Food Addiction Scale (YFAS) was developed according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, diagnostic criteria for substance use disorders, and food addiction can be diagnosed when at least three addiction symptoms are endorsed and a clinically significant impairment or distress is present. Although the prevalence of food addiction diagnoses is increased in individuals with obesity and BED, recent studies which used the YFAS showed that there are also individuals with normal weight who can be classified as being ‘food addicted’. Based on self‐reported eating disorder symptoms, women with current (n = 26) or remitted (n = 20) BN, and a control group of women matched for age and body mass index (n = 63) completed the YFAS and other measures. Results revealed that all patients with current BN received a food addiction diagnosis according to the YFAS while only six (30%) women with remitted BN did. None of the women in the control group received a food addiction diagnosis. Results provide support for the notion that BN can be described as addiction‐like eating behaviour and suggest that food addiction most likely improves when BN symptoms remit. Copyright © 2014 John Wiley & Sons, Ltd and Eating Disorders Association.
Psychotic symptoms in older people without dementia from a Brazilian community‐based sample
Authors: Soares Walter Barbalho , Ribeiz Salma Rose I. , Bassitt Débora P. , De Oliveira Melaine C. , Bottino Cássio M. C. 
Published: July 2014

BackgroundThe international prevalence of psychotic symptoms in older subjects without dementia varies from 0.9% to 8.0%. However, an analysis of these symptoms in developing countries has not been undertaken.AimsTo determine the prevalence and to correlate these symptoms with socioeconomic and clinical characteristics.MethodA community‐based sample aged 60 years and older was evaluated. Those who screened positive for dementia, cognitive and functional impairment or significant depressive symptoms were excluded, resulting in 1125 individuals.ResultsThe prevalence of psychotic symptoms was 9.1% (visual/tactile hallucinations, 7.8%; auditive hallucinations, 7.5%; persecutory delusions, 2.9%). Subjects with psychotic symptoms had lower Mini Mental State Examination and The Bayer Activities of Daily Living Scale scores, fewer years of schooling, belonged to lower socioeconomic classes compared with non‐psychotic subjects, and 80% had clinical comorbidities.ConclusionsThe prevalence was in the upper range of international data. Significant relationships were found between psychotic symptoms and lower Mini Mental State Examination score, fewer years of schooling and lower socioeconomic class. Clinical comorbidity was also very frequent. Copyright © 2014 John Wiley & Sons, Ltd.
Translating cognitive and everyday activity deficits into cognitive interventions in mild dementia and mild cognitive impairment
Authors: Giebel Clarissa , Challis David 
Published: July 2014

ObjectiveMild dementia is marked by deficits in cognition and everyday activities. However, few studies have translated findings from both areas of functioning into effective cognitive rehabilitation. The purpose of this review was to critically evaluate the existing literature on the type and success of interventions and on their extent of use of cognitive theory. Given the limited evidence base in this population, further insights were obtained from studies on mild cognitive impairment (MCI), which involves fewer cognitive and everyday functioning problems than dementia.MethodsFrom the literature searches, 11 studies on mild dementia and three studies on MCI were obtained. Studies were only included if the interventions either targeted instrumental activities of daily living or activities of daily living directly or as an outcome measure or if the interventions focused on real‐life aspects not captured in the standardised daily activities. For inclusion, patients needed a diagnosis of dementia or MCI, and Mini‐Mental State Examination scores had to be above 17 for mild dementia.ResultsThe majority of interventions indicated improved everyday activity performance in early dementia and MCI. Focusing on individual, as opposed to global, daily activities appeared to be an important determinant of intervention success in mild dementia but not in MCI. However, few attempts had been made to develop interventions grounded in evidence‐based models.ConclusionsThis review highlights the need for further translation of the understanding of cognitive and everyday activity deficits into successful interventions for daily activities in MCI and early dementia. Hence, research is first required to link individual activities with cognitive domains. Copyright © 2014 John Wiley & Sons, Ltd.
Unexpected Formation of 2‐Amino‐(1‐(2‐nitrophenylsulfinyl)azulene by the Reaction of 2‐Aminoazulene with 2‐Nitrobenzenesulfonyl Chloride
Authors: Nakagawa Hajime , Tsukada Satoru , Abe Noritaka , Gunji Takahiro 
Published: July 2014

ABSTRACT2‐Amino‐(1‐(2‐nitrophenylsulfinyl)azulene derivatives were synthesized by the reaction of 2‐aminoazulene with 2‐nitrobenzenesulfonyl chloride. Crystal structures of these compounds were determined by X‐ray diffraction analysis. The sulfur atom derived nosyl group shows unique geometry. Furthermore, a reaction using 4‐nitrobenzenesulfonyl chloride is also demonstrated.
Utility of BRAF mutation detection in fine‐needle aspiration biopsy samples read as “suspicious for papillary thyroid carcinoma”
Authors: Jara Sebastian M. , Bhatnagar Ramneesh , Guan Hui , Gocke Christopher D. , Ali Syed Z. , Tufano Ralph P. 
Published: July 2014

ABSTRACT:BackgroundThe purpose of this study was to evaluate the diagnostic utility of BRAF mutation testing on thyroid nodules “suspicious for papillary thyroid carcinoma” (PTC) cytology.MethodsA chart review of patients with fine‐needle aspiration (FNA) results “suspicious for PTC” with subsequent thyroidectomy was performed. Corresponding archived FNA slides underwent BRAF mutation testing.ResultsSixty‐six patients with FNA “suspicious for PTC” underwent thyroidectomy. Forty‐two (63.6%) had PTC diagnosed on final histopathology, whereas 21 (31.8%) had benign findings. Thirty‐five patients (83%) with histologically proven PTC underwent total thyroidectomy, whereas 7 (17%) underwent hemithyroidectomy. BRAF mutation was detected in 17 of 49 samples (34.6%) available for testing and had 45.5% sensitivity, 87.5% specificity, 88.2% positive predictive value (PPV), and 43.8% negative predictive value (NPV) for diagnosing PTC. Two of 4 patients (50%) who underwent hemithyroidectomy with subsequent completion thyroidectomy had mutated BRAF detected.ConclusionBRAF testing is a useful adjunct to improve PPV for patients with “suspicious for PTC” cytology. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1788–1793, 2015
Laryngeal cancer in Finland: A 5‐year follow‐up study of 366 patients
Authors: Haapaniemi Aaro , Koivunen Petri , Saarilahti Kauko , Kinnunen Ilpo , Laranne Jussi , Aaltonen Leena‐Maija , Närkiö Mervi , Lindholm Paula , Grénman Reidar , Mäkitie Antti , Atula Timo ,   The Finnish Head and Neck Oncology Working Group
Published: July 2014

ABSTRACTBackgroundThe purpose of this study was to acquire nationwide data on the management and outcome of laryngeal squamous cell carcinoma (SCC) in Finnish university hospitals over a 5‐year posttreatment follow‐up.MethodsAll records of patients diagnosed and treated for primary laryngeal SCC during 2001 to 2005 were reviewed.ResultsThree hundred sixty‐six patients with laryngeal cancer were identified, 360 of whom had laryngeal SCC. Three hundred forty‐two patients with laryngeal SCC (95%) were treated with curative intent. Five‐year disease‐specific survival (DSS) for T1a, T1b, T2, T3, and T4 glottic SCC was 100%, 95%, 78%, 79%, and 53%, respectively. The corresponding figures for T1 to T4 supraglottic SCC were 68%, 54%, 72%, and 59%.ConclusionResults of this nationwide study give a general overview of the outcome of unselected patients treated with unified guidelines. Patients with T2 tumors, usually treated with radiotherapy (RT), had a worse prognosis than expected. This patient group warrants further investigation and possibly treatment intensification. © 2015 Wiley Periodicals, Inc. Head Neck 38: 36–43, 2016
Impact of race on oropharyngeal squamous cell carcinoma presentation and outcomes among veterans
Authors: Zevallos Jose P. , Sandulache Vlad C. , Hamblin John , Skinner Heath D. , Kramer Jennifer , Hartman Christine M. , Horter Kelsey L. , Lai Syeling , Zhou Xiaodong , Chiao Elizabeth Y. 
Published: July 2014

ABSTRACTBackgroundRacial disparities in oropharyngeal squamous cell carcinoma (SCC) have been demonstrated and attributed to differences in human papillomavirus (HPV) status. The purpose of this study was to examine racial disparities in oropharyngeal SCC among veterans.MethodsRetrospective review of patients with oropharyngeal SCC at a tertiary‐care Veterans Affairs (VA) hospital. Adjusted Cox proportional hazards models were conducted to examine the effect of race on oropharyngeal SCC outcomes.ResultsOf 158 patients, 126 (79.7%) were white and 32 (20.3%) were African American. No difference in p16 tumor expression was noted between the groups. Five‐year disease‐free survival (DFS) was 42.6% and 55.1% for African Americans and whites, respectively (p = .372). Five‐year overall survival (OS) for African Americans and whites was 54.6% and 51.8%, respectively (p = .768). On multivariate analysis, there was no significant difference in risk of recurrence or death by race.ConclusionRacial disparities are largely ameliorated in patients with oropharyngeal SCC treated within the VA, there were no racial differences in p16 tumor expression, and outcomes remain poor. © 2015 Wiley Periodicals, Inc. Head Neck 38: 44–50, 2016
Value of narrow band imaging in the early diagnosis of laryngeal cancer
Authors: Kraft Marcel , Fostiropoulos Karolos , Gürtler Nicolas , Arnoux André , Davaris Nikolaos , Arens Christoph 
Published: July 2014

ABSTRACTBackgroundNarrow band imaging (NBI) is a new imaging technique for the depiction of tumor‐specific neoangiogenesis. The purpose of the present study was to assess the value of NBI in the early diagnosis of laryngeal cancer.MethodsThis prospective study includes 205 consecutive patients with a laryngeal lesion scheduled for microlaryngoscopy. NBI was immediately performed after white light endoscopy (WLE), whereas excisional biopsy was carried out for histologic verification of diagnosis.ResultsIn identifying laryngeal cancer and its precursor lesions, NBI with WLE showed a significantly higher sensitivity (97% vs 79%) and accuracy (97% vs 90%) than WLE alone, but the specificity (96% vs 95%) was essentially equal in both methods.ConclusionNBI qualifies for rapid detection and delineation of suspicious lesions. Additionally, this noninvasive method is also beneficial in a variety of benign lesions. © 2015 Wiley Periodicals, Inc. Head Neck 38: 15–20, 2016
Serglycin expression: An independent marker of distant metastases in nasopharyngeal carcinoma
Authors: Chia Claramae Shulyn , Ong Whee Sze , Li Xin Jian , Soong Yoke‐Lim , Chong Fui Teen , Tan Hiang‐Khoon , Soo Khee‐Chee , Qian Chao‐Nan , Teh Bin‐Tean , Iyer N. Gopalakrishna 
Published: July 2014

ABSTRACTBackgroundNasopharyngeal carcinoma (NPC) has a high propensity for metastasis. The purpose of this study was for us to determine whether serglycin expression can be used to predict distant metastases.MethodsSerglycin expression of tumor tissue of 112 patients with NPC was assessed based on percentage of tumor cells expressing serglycin, staining intensity, percentage of tumor‐infiltrated lymphocyte (TIL) expressing serglycin and TIL‐staining intensity.ResultsRisk factors for distant metastases include sex, smoking status, tumor intensity, and TIL percentage for serglycin. The odds of distant metastases was 4.13 and 0.18 in patients with strong tumor intensity and >50% TIL percentage, respectively. Based on a nomogram incorporating predictors, patients were stratified into 2 prognostic groups. The proportion of distant metastases in the high‐risk group (strong tumor intensity and ≤50% TIL percentage) was 78% versus 19% in the low risk group (p < .001).ConclusionPatients with NPC with tumors showing strong tumor intensity and low TIL percentage with serglycin may be at high risk for distant metastases. © 2015 Wiley Periodicals, Inc. Head Neck 38: 21–28, 2016
Metals discharged during different flow conditions from a mixed agricultural‐forest catchment (NW Spain)
Authors: Soto‐Varela F. , Rodríguez‐Blanco M. L. , Taboada‐Castro M. M. , Taboada‐Castro M. T. 
Published: July 2014

AbstractMetal loads were determined from water samples collected under different streamflow conditions (baseflow and storm events) in a rural catchment (NW Spain) during 4 years. A study at annual, seasonal and storm‐event scales was carried out. In all analysed scales, the export order was Fe > Al > Mn > Zn > Cu. A high inter‐annual, seasonal and storm‐event scale variability of metal load was observed. The total metal loads in stream were higher during baseflow conditions than during storm events, which only represented 4% of the duration of the study period and 25% of streamflow. During storm events, both Al and Fe loads accounted 45% of the total load of the study period, whereas Mn, Cu and Zn loads represented 42%, 33% and 24%, respectively. This highlights the role of high flows on metal export. Only four big events exported around 30% of load of each metal transported in events. At all time scales, a prevalence of export of particulate metals over dissolved metals was observed, more pronounced for Al, Fe and Mn than for Cu and Zn. The export of metals in the Corbeira catchment is influenced by runoff and, to a lesser extent, by the rainfall amount. Copyright © 2014 John Wiley & Sons, Ltd.