bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of local site conditions on seismic performance of free‐spanning submarine pipelines: Underwater shaking table tests and numerical simulations
Authors: Pan Haiyang , Li Chao , Li Hong‐Nan , Ma Ruisheng , Guo Jin 
Published: August 2024

AbstractLocal site conditions may pose a significant influence on the seismic responses of submarine pipelines by altering both the offshore motion propagation and soil‐structure interaction (SSI). This paper aims to provide an in‐depth understanding of the influence regularity of local site conditions on the seismic performance of free‐spanning submarine pipelines (FSSPs). For this purpose, a suite of underwater shaking table tests were performed to investigate the seismic responses of FSSP subjected to the offshore spatial motions at three site categories. Response comparison factor () is defined to quantify the structural response discrepancies caused by the seismic inputs at different sites. The test results indicate that responses of the studied model FSSP gradually increase as spatial offshore motions at softer soil sites are employed as inputs; and the values of vary with a maximum magnitude of up to 40%–60% for different response indices when the site soil changes from fine sand to clay. Subsequently, the corresponding numerical simulations are carried out to reproduce the seismic responses of the test model. The experimental and numerical results meet a good agreement, indicating that the developed numerical modeling method can accurately predict the seismic responses of FSSPs. Following this verified modeling method and using the p‐y approach to address the SSI effect, fragility surfaces of the studied FSSP are derived in terms of PGA and site parameter (shear‐wave velocity in the top 30 m of the soil profile) via probabilistic seismic demand analyses. The impact of local site conditions on the seismic performance of the FSSP is quantitatively examined by comparing the fragility curves corresponding to various . Furthermore, a fast seismic damage assessment method is proposed for efficiently evaluating the performance of FSSPs buried in various offshore soil conditions. This approach proves beneficial for designers and decision‐makers, enabling accurate estimation of seismic damage and facilitating the implementation of post‐earthquake maintenance measures for FSSPs.
Cheirostylis tortilacinia C. S. Leou (Orchidaceae), a new record for India and its typification
Authors: Khanal Madhusudhan , Sarkar Shuvadip , Rai Santosh Kumar , Kumar Devendra , Bhattacharjee Avishek 
Published: August 2024

AbstractCheirostylis tortilacinia C. S. Leou (Orchidaceae), has been reported for the first time in India from Arunachal Pradesh and West Bengal. Cheirostylis tortilacinia is morphologically allied to Cheirostylis parvifolia during anthesis but clear differences can be traced on closer examination of the vegetative morphology and the floral characters. Detailed taxonomical description along with photoplates, species comparison table with the allied species from India, and notes on typification have been provided in this current communication to aid in easy identification of this species.
Cardiovascular effects of long‐duration space flight
Authors: Hussain Iqbal , Ullah Rehmat , Simran Bharti F. N. U. , Kaur Parvinder , Kumar Mahendra , Raj Rohan , Faraz Maria , Mehmoodi Amin , Malik Jahanzeb 
Published: August 2024

AbstractIntroductionEarly studies exploring the physiological effects of space travel have indicated the body's capacity for reversible adaptation. However, the impact of long‐duration spaceflight, exceeding 6 months, presents more intricate challenges.Effects on the Cardiovascular (CV) SystemExtended exposure to microgravity and radiation profoundly affects the CV system. Notable phenomena include fluid shifts toward the head and modified arterial pressure. These changes disrupt blood pressure regulation and elevate cardiac output. Additionally, the loss of venous compression leads to a reduction in central venous pressure.Fluid and Plasma Volume ChangesThe displacement of fluid from the vascular system to the interstitium, driven by baroreceptor stimulation, results in a 10%–15% decline in plasma volume.Cardiac Muscle and Hematocrit VariationsIntriguingly, despite potential increases in cardiac workload, cardiac muscle atrophy and perplexing variations in hematocrit levels have been observed. The mechanism underlying atrophy appears to involve a shift in protein synthesis from the endoplasmic reticulum to the mitochondria via mortalin‐mediated mechanisms.Arrhythmias and QT Interval ProlongationInstances of arrhythmias have been recurrently documented, although generally nonlethal, in both Russian and American space missions. Long‐duration spaceflight has been associated with the prolongation of the QT interval, particularly in extended missions.Radiation EffectsExposure of the heart to the proton and heavy ion radiation pervasive in deep space contributes to coronary artery degeneration, augmented aortic stiffness, and carotid intima thickening through collagen‐mediated processes. Moreover, it accelerates the onset of atherosclerosis and triggers proinflammatory responses.Reentry and Postflight ChallengesUpon reentry, astronauts frequently experience orthostatic intolerance and altered sympathetic responses, which bear potential hazards in scenarios requiring rapid mobilization or evacuation.ConclusionConsequently, careful monitoring of these cardiac risks is imperative for forthcoming missions. While early studies illuminate the adaptability of the body to space travel's challenges, the intricacies of long‐duration missions and their effects on the CV system necessitate continued investigation and vigilance to ensure astronaut health and mission success.
Examining the impact of filling ratio on thermosyphon performance in passive energy recovery processes with dual effects of evaporative cooling: An experimental study
Authors: Mohsin ALsayah Ahmed , Faraj Johain J. , Eidan Adel A. , Alshukri Mohammed J. 
Published: August 2024

AbstractThe thermosyphon heat exchanger contributes significantly to the improvement of energy conservation technology and has been used in multiple applications, raising the possibility of further studies to contribute to increasing the efficiency of heat pipes. This experimental study examines the different filling ratios of pure Acetone liquid inside a WHPHE integrated with the double‐effect of evaporative cooling to improve the energy‐saving technology. This work studies changing the filling ratio of pure acetone working fluid to investigate the effect of the filling ratio on heat exchanger performance in waste energy recovery technology. The heat exchanger was used with four rows and five tubes per row arranged in a staggered manner. The filling ratio of acetone inside the heat pipe was changed from 50% to 100%. The effect of the mass flow rate of air flowing in direct evaporative cooling on energy conservation technology was studied while the mass flow rate of air through indirect cooling remains constant in addition to the effect of ambient temperature. The results showed that the best filling percentage was between 80% at different temperatures, and the highest energy recovery percentage was when it was at the filling percentage of 80% in the presence of evaporative cooling.
Birth companionship: The effect of introducing Plan‐Do‐Study‐Act (PDSA) intervention on improving quality of care: An implementation study
Authors: Lemma Kidist , Bekele Delayehu , Tolu Lemi Belay , Tadesse Felagot , Kifle Tsinat , Sium Abraham Fessehaye 
Published: August 2024

SynopsisPlan‐Do‐Study‐Act (PDSA) intervention is an effective strategy in increasing the practice of birth companionship.
SIRT2 regulates high mobility group protein B1 nucleoplasmic shuttle and degradation via deacetylation in microglia
Authors: Xing Wan‐Qun , Piao Xian‐ji , Han Qi , Shi Hui‐Ying , Wu Wen‐Cong , Si Fan , Lu Jing‐Jing , Zhou Tie‐Zhong , Guo Jing‐Ru , Li Shi‐Ze , Xu Bin 
Published: August 2024

AbstractHigh mobility group protein B1 (HMGB1) acts as a pathogenic inflammatory response to mediate ranges of conditions such as epilepsy, septic shock, ischemia, traumatic brain injury, Parkinson's disease, Alzheimer's disease and mass spectrometry. HMGB1 promotes inflammation during sterile and infectious damage and plays a crucial role in disease development. Mobilization from the nucleus to the cytoplasm is the first important step in the release of HMGB1 from activated immune cells. Here, we demonstrated that Sirtuin 2 (SIRT2) physically interacts with and deacetylates HMGB1 at 43 lysine residue at nuclear localization signal locations, strengthening its interaction with HMGB1 and causing HMGB1 to be localized in the cytoplasm. These discoveries are the first to shed light on the SIRT2 nucleoplasmic shuttle, which influences HMGB1 and its degradation, hence revealing novel therapeutic targets and avenues for neuroinflammation treatment.
Applications and accuracy of 3D‐printed surgical guides in traumatology and orthopaedic surgery: A systematic review and meta‐analysis
Authors: Hess Silvan , Husarek Julius , Müller Martin , Eberlein Sophie C. , Klenke Frank M. , Hecker Andreas 
Published: August 2024

AbstractBackgroundPatient‐Specific Surgical Guides (PSSGs) are advocated for reducing radiation exposure, operation time and enhancing precision in surgery. However, existing accuracy assessments are limited to specific surgeries, leaving uncertainties about variations in accuracy across different anatomical sites, three‐dimensional (3D) printing technologies and manufacturers (traditional vs. printed at the point of care). This study aimed to evaluate PSSGs accuracy in traumatology and orthopaedic surgery, considering anatomical regions, printing methods and manufacturers.MethodsA systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta‐Analysis guidelines. Studies were eligible if they (1) assessed the accuracy of PSSGs by comparing preoperative planning and postoperative results in at least two different planes (2) used either computer tomography or magnetic resonance imaging (3) covered the field of orthopaedic surgery or traumatology and (4) were available in English or German language. The ‘Quality Assessment Tool for Quantitative Studies’ was used for methodological quality assessment. Descriptive statistics, including mean, standard deviation, and ranges, are presented. A random effects meta‐analysis was performed to determine the pooled mean absolute deviation between preoperative plan and postoperative result for each anatomic region (shoulder, hip, spine, and knee).ResultsOf 4212 initially eligible studies, 33 were included in the final analysis (8 for shoulder, 5 for hip, 5 for spine, 14 for knee and 1 for trauma). Pooled mean deviation (95% confidence interval) for total knee arthroplasty (TKA), total shoulder arthroplasty (TSA), total hip arthroplasty (THA) and spine surgery (pedicle screw placement during spondylodesis) were 1.82° (1.48, 2.15), 2.52° (1.9, 3.13), 3.49° (3.04, 3.93) and 2.67° (1.64, 3.69), respectively. Accuracy varied between TKA and THA and between TKA and TSA.ConclusionAccuracy of PSSGs depends on the type of surgery but averages around 2–3° deviation from the plan. The use of PSSGs might be considered for selected complex cases.Level of EvidenceLevel 3 (meta‐analysis including Level 3 studies).
A deep learning‐guided automated workflow in LipidOz for detailed characterization of fungal fatty acid unsaturation by ozonolysis
Authors: Ross Dylan H. , Bredeweg Erin L. , Eder Josie G. , Orton Daniel J. , Burnet Meagan C. , Kyle Jennifer E. , Nakayasu Ernesto S. , Zheng Xueyun 
Published: August 2024

AbstractUnderstanding fungal lipid biology and metabolism is critical for antifungal target discovery as lipids play central roles in cellular processes. Nuances in lipid structural differences can significantly impact their functions, making it necessary to characterize lipids in detail to understand their roles in these complex systems. In particular, lipid double bond (DB) locations are an important component of lipid structure that can only be determined using a few specialized analytical techniques. Ozone‐induced dissociation mass spectrometry (OzID‐MS) is one such technique that uses ozone to break lipid DBs, producing pairs of characteristic fragments that allow the determination of DB positions. In this work, we apply OzID‐MS and LipidOz software to analyze the complex lipids of Saccharomyces cerevisiae yeast strains transformed with different fatty acid desaturases from Histoplasma capsulatum to determine the specific unsaturated lipids produced. The automated data analysis in LipidOz made the determination of DB positions from this large dataset more practical, but manual verification for all targets was still time‐consuming. The DL model reduces manual involvement in data analysis, but since it was trained using mammalian lipid extracts, the prediction accuracy on yeast‐derived data was reduced. We addressed both shortcomings by retraining the DL model to act as a pre‐filter to prioritize targets for automated analysis, providing confident manually verified results but requiring less computational time and manual effort. Our workflow resulted in the determination of detailed DB positions and enzymatic specificity.
Searchsmart.org: Guiding researchers to the best databases and search systems for systematic reviews and beyond
Authors: Gusenbauer Michael 
Published: August 2024

AbstractWhen searching for scholarly documents, researchers often stick with the same familiar handful of databases. Yet, just beyond these limited horizons lie dozens of alternatives with which they could search more effectively, whether for quick lookups or thorough searches in systematic reviews or meta‐analyses. Searchsmart.org is a free website that guides researchers to particularly suitable search options for their particular disciplines, offering a wide array of resources, including search engines, aggregators, journal platforms, repositories, clinical trials databases, bibliographic databases, and digital libraries. Search Smart currently evaluates the coverage and functionality of more than a hundred leading scholarly databases, including most major multidisciplinary databases and many that are discipline‐specific. Search Smart's primary use cases involve database‐selection decisions as part of systematic reviews, meta‐analyses, or bibliometric analyses. Researchers can use up to 583 criteria to filter and sort recommendations of databases and the interfaces through which they can be accessed for user‐friendliness, search rigor, or relevance. With specific pre‐defined filter settings, researchers can quickly identify particularly suitable databases for Boolean keyword searching and forward or backward citation searching. Overall, Search Smart's recommendations help researchers to discover knowledge more effectively and efficiently by selecting the more suitable databases for their tasks.
Visual perception of distance in 3D‐augmented reality head‐up displays
Authors: Lee Tae Hee , Jeong Young Ju 
Published: August 2024

AbstractA head‐up display (HUD) is conveniently used to provide information on the display without changing the user's gaze. 3D HUDs, capable of projecting three‐dimensional information beyond the 2D HUDs, enable the projection of augmented reality (AR) objects into the real world. Research on the perception of 3D AR HUDs is crucial for their efficient utilization and secure commercialization. In this study, we examined whether a 3D HUD is more comfortable than a 2D HUD in the context of viewing real‐world environments and augmented reality objects together. Additionally, we analyzed participants' perception of distance and fatigue for AR objects at varying distances from the 3D HUD. The study found that using a 3D HUD in an AR environment resulted in less fatigue than using a 2D HUD, as determined by a Mann–Whitney statistical analysis. Participants were able to match the depth of AR objects in a 3D HUD within a range of 3 to 50 m, with similar diopter and parallax angular distance errors, regardless of the distance of the AR object. Visual fatigue increases with increasing distance from the virtual‐image plane and can be modeled as a quadratic function in the domain of diopter and parallax angles.
Introduction to the Special Issue on the 39th Annual Meeting of the International Society for Traumatic Stress Studies: Scalable strategies to address the impact of trauma worldwide
Authors: Galatzer‐Levy Isaac R. , Schultebraucks Katharina 
Published: August 2024

AbstractThis editorial summary provides an overview of the 39th annual meeting of the International Society for Traumatic Stress Studies (ISTSS) held from November 1–4, 2023. The meeting, themed “Scalable Strategies to Address the Impact of Trauma Worldwide: Innovations and Implementation,” encouraged presenters to focus on the scalability of traumatic stress research and practice. The articles presented at the meeting, which form this issue, cover a broad spectrum of topics, from basic biological mechanisms to innovative digital engagement to population‐wide treatments. These articles emphasize eliminating biases in research design and psychiatric practice, promoting health equity, and addressing the unique challenges of traumatic stress. This summary underscores the importance of scalability in developing flexible, dynamic, and inclusive mental health care interventions.
Exploring the galvanic corrosion behavior of 6061 aluminum alloy: TA1 titanium alloy based on finite element simulation
Authors: Li Xinyang , Zhang Junkai , Li Lei , Wang Wenjia , Xu Guocheng , Hou Zhonglin 
Published: August 2024

AbstractUsing polarization curve scanning, electrochemical impedance spectroscopy, macroscopic morphology observation, scanning electron microscope, X‐ray diffraction (XRD), and energy dispersive spectroscopy (EDS), the corrosion regulars of connectors were investigated. A galvanic corrosion simulation model of aluminum‐titanium rivets was established by electrochemical experimental parameters as boundary conditions. The results showed that the galvanic couple connection accelerated the corrosion significantly. XRD and EDS results show that the main corrosion products are Al2O3, Al(OH)3. The corrosion potential of riveted parts decreased from the riveting point to both sides, ranging from −0.664 to −0.655 V. The corrosion current density decreases along both sides, and the corrosion current density at the most edge is 0.0113 A/m2. The results of numerical simulation indicate that the model effectively predicted the galvanic corrosion behavior of aluminum‐titanium rivets.
An autoantibody profile identified by human genome‐wide protein arrays in rheumatoid arthritis
Authors: Liu Xu , Zhang Xiaoying , Kang Yu‐Jian , Huang Fei , Liu Shuang , Guo Yixue , Li Yingni , Yin Changcheng , Liu Mingling , Han Qimao , Wang Qingwen , Ye Hua , Yao Haihong , Li Chun , Li Jiahe , Pingcuo Wangzha , Zhang Yan , Su Yin , Gao Ge , Li Zhanguo , Sun Xiaolin 
Published: August 2024

AbstractPrecise diagnostic biomarkers of anticitrullination protein antibody (ACPA)‐negative and early‐stage RA are still to be improved. We aimed to screen autoantibodies in ACPA‐negative patients and evaluated their diagnostic performance. The human genome‐wide protein arrays (HuProt arrays) were used to define specific autoantibodies from the sera of 182 RA patients and 261 disease and healthy controls. Statistical analysis was performed with SPSS 17.0. In Phase I study, 51 out of 19,275 recombinant proteins covering the whole human genome were selected. In Phase II validation study, anti‐ANAPC15 (anaphase promoting complex subunit 15) exhibited 41.8% sensitivity and 91.5% specificity among total RA patients. There were five autoantibodies increased in ACPA‐negative RA, including anti‐ANAPC15, anti‐LSP1, anti‐APBB1, anti‐parathymosin, and anti‐UBL7. Anti‐parathymosin showed the highest prevalence of 46.2% (p = 0.016) in ACPA‐negative early stage (<2 years) RA. To further improve the diagnostic efficacy, a prediction model was constructed with 44 autoantibodies. With increased threshold for RA calling, the specificity of the model is 90.8%, while the sensitivity is 66.1% (87.8% in ACPA‐positive RA and 23.8% in ACPA‐negative RA) in independent testing patients. Therefore, HuProt arrays identified RA‐associated autoantibodies that might become possible diagnostic markers, especially in early stage ACPA‐negative RA.
Nutrition outcomes of disease modifying therapies in spinal muscular atrophy: A systematic review
Authors: O'Brien Katie , Nguo Kay , Yiu Eppie M. , Woodcock Ian R. , Billich Natassja , Davidson Zoe E. 
Published: August 2024

AbstractThe nutritional implications of spinal muscular atrophy (SMA) are profound. Disease modifying therapies (DMT) have improved clinical outcomes. This review describes the impact of DMT on nutrition outcomes. A systematic search strategy was applied across seven databases until May 2023. Eligible studies measured nutrition outcomes in individuals with SMA on DMT (nusinersen, risdiplam or onasemnogene abeparvovec [OA]) compared to untreated comparators. Nutrition outcomes included anthropometry, feeding route, swallowing dysfunction, dietary intake, dietetic intervention, nutritional biochemistry, metabolism, gastrointestinal issues and energy expenditure. Articles retrieved were screened in duplicate, data were extracted and appraised systematically. Sixty three articles from 54 studies were included; 41% (n = 22) investigated nusinersen in pediatric participants with SMA type 1. Anthropometry (n = 18), feeding route (n = 39), and swallowing dysfunction (n = 18) were the most commonly reported outcomes. In combined pediatric and adult cohorts, BMI z‐score remained stable post nusinersen therapy. The proportion of children with SMA requiring enteral nutrition was stable post nusinersen therapy. Ability to thrive at age 1.5 years was higher in children treated in early infancy with OA compared to historical controls. Significant heterogeneity existed across study population characteristics and outcome measures. Nusinersen may prevent deterioration in some nutrition outcomes; and OA in early infancy may be associated with improved nutrition outcomes. Timing of DMT initiation is an important consideration for future nutrition research. Studies investigating nutrition as a primary outcome of DMT, using consistent outcome measures are required for nutritional management strategies for this cohort to be appropriately tailored.
Organization of shared care networks and their role in overcoming challenges and enhancing outcomes for childhood cancer: A systematic review
Authors: Afungchwi Glenn Mbah , Waindim Yvonne , Pondy‐Ongotsoyi Angele , Essono Justine , Youwa Prisca , Frambo Andreas , Tayou Rachael , Grace Nyemb Mbog , Kengang Armelle , Eyambe Lydia , Farida Haoua , Chishugi John , Kouya Francine , Nkegoum Blaise 
Published: August 2024

AbstractThis systematic review examines shared care networks (SCNs) in pediatric oncology as a strategic response to the healthcare challenges in low‐ and middle‐income countries. SCNs integrate specialized hubs with local satellite centers to enhance accessibility and quality of care. Our methodology included a search of PubMed, Embase, Google Scholar, and Scopus, selecting peer‐reviewed articles from the last 20 years. We analyzed nine studies, focusing on SCN definitions, models, and outcomes. Findings reveal that SCNs improve clinical outcomes and patient satisfaction, while reducing economic and emotional burdens through standardized protocols and efficient referral systems. Despite the benefits, challenges remain in maintaining consistent care quality and communication across centers. The review underscores the need for further research to quantify benefits, examine long‐term outcomes, and refine operational practices to optimize SCNs’ effectiveness in pediatric oncology.