bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency selective surface filters with polarized band pass/band reject performances
Authors: D'Assunção A. G. , Fontgalland G. , Neto A. Gomes , Baudrand Henri 
Published: December 2013

ABSTRACTThis work presents a wave concept iterative procedure design of a frequency selective surface (FSS) structure, which elements are composed by integration of square ring and cross dipole conducting patch elements. The proposed FSS geometry allows the development of a band pass or band reject filter, depending of the incident wave polarization. Simulated and measured results for the transmission coefficient are compared and a good agreement is observed. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:483–487, 2014
Precise measurement of fiber dispersion based on phase‐modulated signal fading
Authors: Zhang Shangjian , Zou Xinhai , Zhang Yali , Zhang Xiaoxia , Liu Yong 
Published: December 2013

ABSTRACTWe propose a novel method for accurately measuring the chromatic dispersion based on the fading effect of the phase‐modulated signal. The fiber dispersion, acting as an optical phase filter, causes the periodical fading of the phase‐modulated signal, and the polynomial fitting of the fading curve enables the precise determination of the characteristic notch frequency and the fiber dispersion. Our method can be used for the chromatic dispersion measurement at different operating wavelengths and dispersive fibers by using a vector network analyzer. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:427–430, 2014
Optical fiber humidity sensor based on a tapered fiber with hydroxyethylcellulose/polyvinylidenefluoride composite
Authors: Lokman Asiah , Nodehi Somayeh , Batumalay M. , Arof H. , Ahmad H. , Harun Sulaiman Wadi 
Published: December 2013

ABSTRACTA simple relative humidity (RH) sensor is demonstrated using a tapered fiber with an hydrogel coating. Hydroxyethylcellulose/polyvinylidenefluoride polymers are used to form the hydrogel coating of the tapered fiber as they are sensitive to moisture and thus the humidity of the atmosphere. Changes in humidity level alter the refractive index of the fiber coating and this condition leads to variation in optical output power. A difference of up to 0.89 dB of the transmitted optical power is observed when RH changes from 50 to 80%. The proposed sensor has a sensitivity of about 0.0228 dB/%RH with a slope linearity of more than 99.91%. In summary, the hydrogel coating acts as an inner cladding whose refractive index decreases with the rise in humidity and thus allows more light to be transmitted in humid state. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:380–382, 2014
Circularly polarized meshed patch antenna using coplanar Y‐shaped coupling feed
Authors: Yasin Tursunjan , Baktur Reyhan 
Published: December 2013

ABSTRACTThis article describes a circularly polarized optically transparent meshed patch antenna designed for small satellite applications. The antenna consists of a nearly square meshed patch that is fed with a coplanar Y‐shaped feed. The configuration of the antenna and feed network has the advantage of being integrable with solar panels of small satellites to resolve the limited surface area issue. The results for a prototyped left‐handed circularly polarized antenna operating at 2.34 GHz are presented. The axial ratio is 2 dB, and the gain is 4.7 dB at the center frequency. The 10‐dB impedance bandwidth is close to 2% and the 3‐dB axial ratio bandwidth is 7 MHz. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:487–489, 2014
A wide‐locking ÷3 BiCMOS injection‐locked frequency divider using internal feedback
Authors: Jang Sheng‐Lyang , Hsieh Jen‐Hsiang , Juang Miin‐Horng 
Published: December 2013

ABSTRACTA wide locking range divide‐by‐3 injection‐locked frequency divider (ILFD) using a standard 0.18‐μm SiGe 3P6M BiCMOS process is presented. The ÷3 ILFD circuit is realized with an n‐core MOS LC‐tank oscillator. The ILFD uses a push‐push signal circuit and two linear mixers with one radio‐frequency injection input port and one push‐push signal input port. An HBT is used to amplify the push‐push signal and extend locking range. The core power consumption of the ILFD core is 13.2 mW at the drain‐source voltage of 0.8 V. The divider's free‐running frequency is tunable from 3.079 to 3.163 GHz and at the incident power of 0 dBm, the locking range is 19.28%, from 8.9 to 10.8 GHz. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:493–497, 2014
Improved band‐notch techniques for miniature UWB CPW‐fed slot antenna
Authors: Naser‐Moghadasi Mohammad , Asadpor Loghman 
Published: December 2013

ABSTRACTThis article describes a compact ultrawideband (UWB) antenna that exhibits desirable band‐notch and gain characteristics. The antenna consists of a rectangular aperture etched on a printed circuit board's ground plane that is excited by a rectangular‐shaped patch. It uses a novel technique comprising of open‐end stubs at the periphery of the ground in the vicinity of the feed‐line to improve its voltage standing wave ratio (VSWR) performance across the UWB. The proposed antenna uses three techniques to provide band‐notch function necessary to eliminate the wireless local‐area network interfering signals between 5 and 6 GHz. The frequency of the band‐notch characteristic can be tuned by varying the parameters defining the notch structure. The antenna was fabricated and its performance measured to validate its feasibility including the band‐notch techniques. A compact 19 × 19 mm2 antenna with aperture area of 9 × 18 mm2 was realized that exhibits an excellent VSWR performance and stable radiation patterns across the UWB spectrum. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:408–415, 2014
Millimeter‐wave coplanar waveguide series stubs on BCB and low resistivity silicon
Authors: Islam Rownak , Henderson Rashaunda 
Published: December 2013

ABSTRACT30–225 GHz coplanar waveguide (CPW) series stubs are studied in a benzocylobutene and 10‐Ω‐cm silicon stack. Truncated side grounds improve the rejection of a 230 GHz CPW band pass filter (BPF). Silicon shielding using a grounded CPW line provides 1.79 dB insertion loss for a 215 GHz BPF. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:375–380, 2014
Combined exposure to agriculture pesticides, paraquat and maneb, induces alterations in the N/OFQ—NOPr and PDYN/KOPr systems in rats: Relevance to sporadic Parkinson's disease
Authors: Bastías‐Candia Sussy , Di Benedetto Manuela , D'Addario Claudio , Candeletti Sanzio , Romualdi Patrizia 
Published: December 2013

ABSTRACTDespite several years of research, the aetiology of Parkinson's disease (PD) is quite far from being solved. In PD, as well as in other neurodegenerative disorders, it has been proposed that the combination of multiple factors might contribute to the onset of the disease. Indeed, several authors have suggested that environmental factors, such as pollutants and chemicals, might be associated with the onset of several neurodegenerative disorders. On the other hand, several studies have described that the nociceptin/orphanin‐NOP and prodynorphin‐KOP opioid systems are implicated in the pathology of Parkinson's disease. Considering the nonrestricted commercial availability and common use of several pesticides, such as paraquat and maneb, in agriculture of less developed countries, the aim of our study was to investigate the involvement of nociceptin/orphanin‐NOP and prodynorphin‐KOP systems in a chronic paraquat and maneb animal model of Parkinson's disease. Our results showed that after paraquat/maneb (5/15 mg kg−1) treatment, a significant reduction in tyrosine hydroxylase (TH) levels, the rate‐limiting enzyme for dopamine synthesis, was observed. Also, the association of paraquat and maneb (5/15 mg kg−1) induced an increase in nociceptin/orphanin and a decrease of prodynorphin gene expression levels in the substantia nigra with a down‐regulation of NOP and KOP receptors after both treatments in the substantia nigra and caudate putamen. These data further confirm that paraquat and maneb toxicity can modulate gene expression of the nociceptin/orphanin‐NOP receptor and prodynorphin‐KOP receptor systems in the substantia nigra and caudate putamen, offering further support to the hypothesis that chronic exposure to these agrochemicals might be implicated in the mechanisms underlying sporadic Parkinson's disease. © 2013 Wiley Periodicals, Inc. Environ Toxicol 30: 656–663, 2015.
Impact of atrial fibrillation on long‐term clinical outcomes in outpatients with heart failure
Authors: Kaneko Hidehiro , Suzuki Shinya , Kano Hiroto , Matsuno Shunsuke , Otsuka Takayuki , Takai Hideaki , Uejima Tokuhisa , Oikawa Yuji , Yajima Junji , Koike Akira , Nagashima Kazuyuki , Kirigaya Hajime , Sagara Koichi , Tanabe Hiroaki , Sawada Hitoshi , Aizawa Tadanori , Yamashita Takeshi 
Published: December 2013

AbstractBackgroundAtrial fibrillation (AF) is a common arrhythmia in patients with heart failure (HF); however, its impact on unselected outpatients with HF remains unclear.MethodsWe followed 2024 symptomatic outpatients with HF who visited the Cardiovascular Institute Hospital (The Shinken Database: 2004–2011, N=17,517). We examined the prevalence, clinical characteristics, and outcomes of AF in these outpatients with HF.ResultsAF was observed in 310 of the patients (15%). Patients with AF were older; more likely to be female; and had lower rates of hypertension, diabetes mellitus, and ischemic heart disease. However, they also had higher rates of New York Heart Association grades III/IV, lower left ventricular ejection fraction (EF), renal dysfunction, and dilated cardiomyopathy. The use of cardiovascular drugs including beta‐blockers, renin‐angiotensin‐system inhibitors, diuretics, digitalis, and antiarrhythmic drugs was more common in patients with AF. Kaplan–Meier curves revealed that the incidences of all‐cause death, cardiovascular disease death, and HF‐related admission were significantly higher in patients with AF. Kaplan–Meier curves and an unadjusted Cox regression analysis showed that AF was associated with a significantly higher risk of all‐cause death, cardiovascular death, and HF‐related admission. However, the adjusted Cox regression model showed that AF was no longer an independent risk factor for all‐cause death, cardiovascular death, and HF death but remained an independent risk factor of HF‐related admission (hazard ratio, 1.781; 95% confidence interval, 1.172–2.704; p=0.007).ConclusionsAF was frequently observed in outpatients with HF. AF was not associated with long‐term mortality but was independently associated with HF‐related admission in this outpatient population.
Secular chaos and its application to Mercury, hot Jupiters, and the organization of planetary systems
Authors: Lithwick Yoram , Wu Yanqin 
Published: December 2013

Significance
Planets perturb one another as they orbit their star. These perturbations can build up over a long time, leading to instability and chaos, and, ultimately, to dramatic events such as interplanetary collisions. We focus here on “secular chaos,” which is the chaos that arises in the orbit-averaged equations. We explain how secular chaos works and show that it explains the chaos of Mercury's orbit. We also show that secular chaos could be responsible for the formation of “hot Jupiters,” which are Jupiter-mass planets that orbit very close to their star. Finally, we suggest that secular chaos might be important not only for Mercury and hot Jupiters, but also more generally for organizing a wide variety of extrasolar planetary systems.
Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme
Authors: Kang Wonchull , Hong Se Hoon , Lee Hye Min , Kim Na Yeon , Lim Yun Chan , Le Le Thi My , Lim Bitna , Kim Hyun Chul , Kim Tae Yeon , Ashida Hiroki , Yokota Akiho , Hah Sang Soo , Chun Keun Ho , Jung Yong-Keun , Yang Jin Kuk 
Published: December 2013

Significance
Apaf-1 interacting protein (APIP) inhibits two main types of programmed cell death: apoptosis and pyroptosis. In addition, APIP is a 5-methylthioribulose-1-phosphate dehydratase (MtnB) in the methionine salvage pathway. We verified its enzymatic activity directly through an enzyme assay and determined its high-resolution structure. Furthermore, we explored the relationship between two distinct functions of APIP/MtnB, cell death inhibition and methionine salvage, and determined that it functions as a cell death inhibitor independently of its MtnB enzyme activity for apoptosis, but dependently for caspase-1–induced pyroptosis. Our results provide groundwork for studies of the role of APIP/MtnB in development of cancers and inflammatory diseases.
Mathematical modeling of primary succession of murine intestinal microbiota
Authors: Marino Simeone , Baxter Nielson T. , Huffnagle Gary B. , Petrosino Joseph F. , Schloss Patrick D. 
Published: December 2013

Significance
The colonization of the intestinal track by the trillions of bacteria that live in the gut (i.e., the gut microbiome) is a dynamic process. Through the use of next-generation sequencing and mathematical models, we were able to quantify the interpopulation interactions that occurred after a germfree mouse was inoculated with a murine microbiome. This approach was significant because we were able to quantify these interactions in vivo without the use of cultivation. Although colonization is most commonly associated with the development of a neonate’s microbiome, understanding the ecological mechanisms involved in the successional process is critical to understanding the recovery of the microbiome following antibiotic therapies, changes in diet, and shifts in health.
Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus
Authors: Ribeiro Luís F. , Catarino Tatiana , Santos Sandra D. , Benoist Marion , van Leeuwen J. Fiona , Esteban José A. , Carvalho Ana Luísa 
Published: December 2013

Significance
Ghrelin is a peptide released from the empty stomach into circulation, and which acts on the brain to promote appetite. Recent studies showed that ghrelin also affects cognition, but the mechanism for this effect is unknown. We show that activation of ghrelin receptors in the hippocampus enhances synaptic signaling by glutamate, the major excitatory neurotransmitter in the brain. Ghrelin promotes the synaptic accumulation of glutamate receptors of the AMPA subtype, and increases long-term potentiation, one form of synaptic plasticity that is thought to underlie learning and memory. These molecular effects of ghrelin in the hippocampus may contribute to the cognition-enhancing role of ghrelin.
Direct observation of a transient ternary complex during IκBα-mediated dissociation of NF-κB from DNA
Authors: Alverdi Vera , Hetrick Byron , Joseph Simpson , Komives Elizabeth A. 
Published: December 2013

Significance
The nuclear factor kappa B (NF-κB) family of transcription factors regulates hundreds of genes in response to stress. Stress responses must be robust when needed and then completely and rapidly turned off. A family of inhibitor proteins, the IκBs, is responsible for turning off NF-κBs. Our study shows that IκBα turns off NF-κB(RelA/p50) by rapidly binding to the DNA-bound NF-κB, forming a transient ternary complex. The ternary complex lasts for only milliseconds before the DNA dissociates from the complex. The resulting IκBα–NF-κB complex is extremely stable and cannot be dissociated. Our study shows how the macromolecular interactions of IκBα are precisely tuned to efficiently and irreversibly turn off NF-κB transcriptional activity.
Seasonal ITCZ migration dynamically controls the location of the (sub)tropical Atlantic biogeochemical divide
Authors: Schlosser Christian , Klar Jessica K. , Wake Bronwyn D. , Snow Joseph T. , Honey David J. , Woodward E. Malcolm S. , Lohan Maeve C. , Achterberg Eric P. , Moore C. Mark 
Published: December 2013

Significance
Low concentrations of fixed nitrogen restrict phytoplankton growth in much of the low-latitude surface oceans. Diazotrophic cyanobacteria are capable of fixing atmospheric dinitrogen, thereby replenishing the overall pool of fixed nitrogen. As a consequence, spatial–temporal variability in diazotrophy can potentially influence the global nitrogen cycle. Here we show that movement in the region of elevated iron concentrations tied to the seasonal migration of the intertropical convergence zone drives a shift in the latitudinal distribution of dinitrogen fixation and corresponding phosphate depletion in surface waters. Surface nutrient concentrations and diazotrophic activity divide the (sub)tropical Atlantic into a high-phosphate, low-iron system in the south, and a low-phosphate, high-iron system in the north.
Dynamic pricing of network goods with boundedly rational consumers
Authors: Radner Roy , Radunskaya Ami , Sundararajan Arun 
Published: December 2013

Significance
A consumer’s demand for a network good depends on the demands of other consumers, and therefore choosing this demand optimally poses a cognitive challenge for most consumers. In our model of pricing a network good, consumers display “bounded rationality” (in Herbert Simon’s sense), and the vendor chooses a dynamic price path to maximize the present value of profit. The result is a price and quantity path that differs significantly from that predicted by standard economic theory and is closer to empirical observations.
Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination
Authors: Furman David , Hejblum Boris P. , Simon Noah , Jojic Vladimir , Dekker Cornelia L. , Thiébaut Rodolphe , Tibshirani Robert J. , Davis Mark M. 
Published: December 2013

SignificanceThere are marked differences between the sexes in their immune response to infections and vaccination, with females often having significantly higher responses. However, the mechanisms underlying these differences are largely not understood. Using a systems immunology approach, we have identified a cluster of genes involved in lipid metabolism and likely modulated by testosterone that correlates with the higher antibody-neutralizing response to influenza vaccination observed in females. Moreover, males with the highest testosterone levels and expression of related gene signatures exhibited the lowest antibody responses to influenza vaccination. This study generates a number of hypotheses on the sex differences observed in the human immune system and their relationship to mechanisms involved in the antibody response to vaccination.
BK channel opening involves side-chain reorientation of multiple deep-pore residues
Authors: Chen Xixi , Yan Jiusheng , Aldrich Richard W. 
Published: December 2013

Significance
The BK calcium-activated potassium channels are important regulators of electrical and calcium signaling in many types of tissue. BK channel activation involves complex conformational changes. We investigated the molecular details of such conformational changes with scanning mutagenesis and electrophysiological measurements. We found multiple pore residues that reorient their side chains during channel opening. These findings bridge the gap between our knowledge about the static X-ray structure of ion channel pores and knowledge about their functional dynamics.
Designed amyloid fibers as materials for selective carbon dioxide capture
Authors: Li Dan , Furukawa Hiroyasu , Deng Hexiang , Liu Cong , Yaghi Omar M. , Eisenberg David S. 
Published: December 2013

Significance
New and improved materials capable of binding carbon dioxide are essential to addressing the global threat of accelerating climate change. The presently used industrial methods for carbon dioxide capture have severe drawbacks, including toxicity and energy inefficiency. Newer porous materials are so far less effective in water, invariably a component of combustion gases. Here, we present a material for carbon dioxide capture. This material, amyloid fibers in powdered form, selectively captures carbon dioxide in the presence of water and binds carbon dioxide strongly until it is released by heating, regenerating the robust amyloid fibers in an energy efficient process.
Impact of Medicare's Payment Policy on Mediastinitis Following Coronary Artery Bypass Graft Surgery in US Hospitals
Authors: Calderwood Michael S. , Kleinman Ken , Soumerai Stephen B. , Jin Robert , Gay Charlene , Piatt Richard , Kassler William , Goldmann Donald A. , Jha Ashish K. , Lee Grace M. 
Published: December 2013

Background.The Centers for Medicare and Medicaid Services (CMS) implemented a policy in October 2008 to eliminate additional Medicare payment for mediastinitis following coronary artery bypass graft (CABG) surgery.Objective.To evaluate the impact of this policy on mediastinitis rates, using Medicare claims and National Healthcare Safety Network (NHSN) prospective surveillance data.Methods.We used an interrupted time series design to compare mediastinitis rates before and after the policy, adjusted for secular trends. Billing rates came from Medicare inpatient claims following 638,761 CABG procedures in 1,234 US hospitals (January 2006-September 2010). Prospective surveillance rates came from 151 NHSN hospitals in 29 states performing 94,739 CABG procedures (January 2007-September 2010). Logistic regression mixed-effects models estimated trends for mediastinitis rates.Results.We found a sudden drop in coding for index admission mediastinitis at the time of policy implementation (odds ratio, 0.36 [95% confidence interval (CI), 0.23-0.57]) and a decreasing trend in coding for index admission mediastinitis in the postintervention period compared with the preintervention period (ratio of slopes, 0.83 [95% CI, 0.74-0.95]). However, we saw no impact of the policy on infection rates as measured using NHSN data. Our results were not affected by changes in patient risk over time, heterogeneity in hospital demographics, or timing of hospital participation in NHSN.Conclusions.The CMS policy of withholding additional Medicare payment for mediastinitis on the basis of claims-based evidence of infection was associated with changes in coding for infections but not with changes in actual infection rates during the first 2 years after policy implementation.
CCAT: Combinatorial Code Analysis Tool for transcriptional regulation
Authors: Jiang Peng , Singh Mona 
Published: December 2013

AbstractCombinatorial interplay among transcription factors (TFs) is an important mechanism by which transcriptional regulatory specificity is achieved. However, despite the increasing number of TFs for which either binding specificities or genome-wide occupancy data are known, knowledge about cooperativity between TFs remains limited. To address this, we developed a computational framework for predicting genome-wide co-binding between TFs (CCAT, Combinatorial Code Analysis Tool), and applied it to Drosophila melanogaster to uncover cooperativity among TFs during embryo development. Using publicly available TF binding specificity data and DNaseI chromatin accessibility data, we first predicted genome-wide binding sites for 324 TFs across five stages of D. melanogaster embryo development. We then applied CCAT in each of these developmental stages, and identified from 19 to 58 pairs of TFs in each stage whose predicted binding sites are significantly co-localized. We found that nearby binding sites for pairs of TFs predicted to cooperate were enriched in regions bound in relevant ChIP experiments, and were more evolutionarily conserved than other pairs. Further, we found that TFs tend to be co-localized with other TFs in a dynamic manner across developmental stages. All generated data as well as source code for our front-to-end pipeline are available at http://cat.princeton.edu.