bluuebunny/crossref_metadata_2025_split huggingface dataset:
MONITORING AND ANALYSIS OF STUDENTS' PERFORMANCE DURING SOFTWARE DEVELOPMENT
Authors: Sharyhin Oleksandr , Fedorets Vasyl , Klochko Oksana 
Published: June 2024

This study presents a comprehensive approach to monitoring and analyzing students’ performance in the context of software development projects. The primary focus is on the development of novel performance metrics that effectively capture the level of control required from the Team Leader and the quality of work assessed by the QA Engineer. The introduced metrics, namely Relative Control Degree and Relative Quality Assurance Degree, offer a robust framework for evaluating and understanding students’ performance across project, company, and industry levels.
This study presents an innovative application that calculates the defined performance metrics, allowing for real-time monitoring of students’ performance as a Developer. This practical tool offers means to track and evaluate student progress throughout the project lifecycle, enabling timely feedback and intervention as needed.
The authors provide recommendations for interpreting the results and utilizing the proposed performance metrics.
The utilization of the developed performance metrics holds significant implications for project management and student development. By implementing the recommended practices, educational institutions and industry professionals can enhance the effectiveness of software development projects, improve student learning outcomes, and promote a culture of continuous improvement and innovation.
The following methods, models, and approaches were used to solve the task of improving monitoring and analyzing the progress of students in the process of participating in software development projects: System and Problem Approaches, Cluster Analytical and Monitoring Models of Software Development, Expert Survey, Consistency Index, Consistency Ratio, the Fundamental Scale of Absolute Numbers by T. L. Saaty, and others.
The proposed performance metrics, supported by recommendations and a dedicated application, empower project stakeholders to optimize control, quality assurance, and student development.
OPTIMALISASI PELAYANAN TERDEPAN BERBASIS ONLINE (PETABA ON) DALAM PENERBITAN KTP ELEKTRONIK (E-KTP) DI DINAS KEPENDUDUKAN DAN PENCATATAN SIPIL KABUPATEN PIDIE
Authors: Maulana Arief , Ansari Rifanda 
Published: June 2024

Penelitian ini dilakukan untuk menelaah sejauh mana optimalisasi pelayanan terdepan berbasis online (Petaba On) dalam penerbitan KTP Elektronik (e-KTP) di Dinas Kependudukan dan Pencatatan Sipil Kabupaten Pidie. Optimalisasi ini mengenai tugas dan peranan Dinas Kependudukan dan Pencatatan Sipil Kabupaten Pidie dalam mengoptimalkan program Petaba On tersebut. Studi ini juga menganalisis hambatan yang dialami serta upaya yang telah dilakukan untuk mengoptimalisasikan Petaba On ini agar mencapai sasaran dan tujuan yang telah ditetapkan. Metode yang digunakan dalam penelitian ini adalah penelitian kualitatif dengan pendekatan induktif, sedangkan metode yang digunakan dalam pengumpulan data adalah dengan melakukan observasi, wawancara dan dokumentasi. Pemilihan informan dilakukan secara purposive sampling dan pada masyarakat secara accidental sampling. Analisis data dilakukan dengan model interaktif Miles, Huberman and Saldana (2014). Dari hasil penelitian menunjukkan bahwa optimalisasi Petaba On dalam penerbitan e- KTP belum berjalan optimal jika dilihat dari dimensi efisiensi dan efektifitas. Apabila dilihat dari dimensi ekonomis, Petaba On telah optimal dikarenakan dapat menghemat waktu, mempersingkat jarak tempuh, dan mengurangi biaya yang harus dikeluarkan publik. Hambatan yang dialami selama pelaksanaan Petaba On ini antara lain adalah kurangnya anggaran untuk operasional Petaba On, minimnya sumber daya manusia baik dari segi kualitas dan kuantitas, dan sarana dan prasarana yang belum memadai. Adapun upaya yang dilakukan untuk optimalisasi Petaba On adalah dengan menyusun kembali rencana kerja anggaran yang lebih mengakomodasi suksesnya program tersebut, pembentukan Petugas Registrasi Gampong (PRG) yang lebih baik, dan meningkatkan koordinasi di level kecamatan.
Kata Kunci: e-KTP, Pelayanan Administrasi, Pencatatan Sipil, Petaba On
Interpretation of the effects of rumen acidosis on the gut microbiota and serum metabolites in calves based on 16S rDNA sequencing and non-target metabolomics
Authors: Wu Fanlin , Ji Peng , Yang Haochi , Zhu Xiaopeng , Wu Xiaohu 
Published: June 2024

IntroductionRumen acidosis is one of the most common diseases in beef cattle. It severely affects the normal development of calves and poses a significant threat to the farming industry. However, the influence of rumen acidosis on the gut microbiota and serum metabolites of calves is currently unclear.ObjectiveThe aim of this study is to investigate the changes in the gut microbiota and serum metabolites in calves after rumen acidosis and analyse the correlation.MethodsEight calves were selected as the rumen acidosis group, and eight health calves were selected as the healthy group. The faecal gut microbiota and serum metabolites of calves were detected respectively using 16S rDNA high-throughput sequencing and non-target metabolomics. The correlation between gut microbiota and serum metabolites was analyzed by Spearman correlation analysis.ResultsDifferential analysis of the diversity and composition of gut microbiota between eight male healthy (Health) and eight male rumen acidosis (Disease) calves revealed that rumen acidosis increased the abundance of the gut microbiota in calves. At the phylum level, compared to the Healthy group, the relative abundance of Proteobacteria in the Disease group significantly decreased (P&lt;0.05), while the relative abundance of Desulfobacterota significantly increased in the Disease group (P&lt;0.05). At the genus level, compared to the Disease group, the relative abundance of Alloprevotella, Muribaculaceae, Succinivibrio, Prevotella, Agathobacter and Parabacteroides significantly increased in the Healthy group (P&lt;0.05), while the relative abundance of Christensenellaceae_R-7 and Monoglobus significantly decreased in the Healthy group (P&lt;0.05). Differential analysis results showed the Healthy group had 23 genera with higher abundance, while the Disease group had 47 genera with higher abundance. Serum metabolomics results revealed the differential metabolites associated with rumen acidosis, including nicotinamide, niacin, L-glutamic acid and carnosine, were mainly enriched in the nicotinate and nicotinamide pathway and the histidine pathway.ConclusionThe occurrence of rumen acidosis can induce changes in the gut microbiota of calves, with a significant increase of the Christensenellaceae_R-7 genus and a significant decrease of Prevotella and Succinivibrio genera. In addition, the occurrence of rumen acidosis can also induce changes in serum metabolites including niacin, niacinamide, L-glutamine, and carnosine, which may serve as the diagnostic biomarkers of rumen acidosis of calves.
Causal relationships exist between polycystic ovary syndrome and adverse pregnancy and perinatal outcomes: a Mendelian randomization study
Authors: Ma Yuanlin , Cai Jiahao , Liu Lok-Wan , Wen Tianrui , Huang Weina , Hou Wenhui , Wei Zixin , Xu Yan , Xu Yanwen , Wang Yizi , Mai Qingyun 
Published: June 2024

IntroductionPrevious observational studies have shown that polycystic ovary syndrome (PCOS) was associated with adverse pregnancy and perinatal outcomes. However, it remains controversial whether PCOS is an essential risk factor for these adverse pregnancy and perinatal outcomes. We aimed to use instrumental variables in a two-sample Mendelian randomization (MR) study to determine causality between PCOS and adverse pregnancy and perinatal outcomes.Materials and methodsSummary statistics were extracted from a recent genome-wide association study (GWAS) meta-analysis conducted in PCOS, which included 10,074 cases and 103,164 controls of European ancestry. Data on Adverse pregnancy and perinatal outcomes were summarized from the FinnGen database of European ancestry, which included more than 180,000 samples. The inverse variance weighted (IVW) method of MR was applied for the main outcome. To assess heterogeneity and pleiotropy, we conducted sensitivity analyses, including leave-one-out analysis, weighted median, MR-PRESSO (Mendelian Randomization Pleiotropy RESidual Sum and Outlier), and MR-Egger regression.ResultsTwo-sample MR analysis with the IVW method suggested that PCOS exerted causal effects on the risk of hypertensive disorders of pregnancy [odds ratio (OR) 1.170, 95% confidence interval (CI) 1.051–1.302, p = 0.004], in particular gestational hypertension (OR 1.083, 95% CI 1.007–1.164, p = 0.031), but not other pregnancy and perinatal diseases (all p &gt; 0.05). Sensitivity analyses demonstrated pleiotropy only in pre-eclampsia or eclampsia (p = 0.0004), but not in other pregnancy and perinatal diseases (all p &gt; 0.05). The results remained consistent after excluding two outliers (all p &gt; 0.05).ConclusionsWe confirmed a causal relationship between PCOS and hypertensive disorders of pregnancy, in particular gestational hypertension, but no association with any other adverse pregnancy or perinatal outcome. Therefore, we suggest that women with PCOS who are pregnant should have their blood pressure closely monitored.
Nijmegen breakage syndrome: 25-year experience of diagnosis and treatment in Ukraine
Authors: Boyarchuk Oksana , Kostyuchenko Larysa , Akopyan Hayane , Bondarenko Anastasiia , Volokha Alla , Hilfanova Anna , Savchak Ihor , Nazarenko Liliia , Yarema Nataliia , Urbas Olha , Hrabovska Iryna , Lysytsia Oleksandr , Budzyn Andrii , Tykholaz Oksana , Ivanchuk Mariana , Bastanohova Olha , Patskun Erika , Vasylenko Nataliia , Stepanovskyy Yuriy , Chernyshova Liudmyla , Makukh Halyna 
Published: June 2024

IntroductionNijmegen breakage syndrome (NBS) is an autosomal recessive disorder, characterized by microcephaly, immunodeficiency, and impaired DNA repair. NBS is most prevalent among Slavic populations, including Ukraine. Our study aimed to comprehensively assess the prevalence, diagnosis, clinical data, immunological parameters, and treatment of NBS patients in Ukraine.MethodsWe conducted a retrospective review that included 84 NBS patients from different regions of Ukraine who were diagnosed in 1999-2023. Data from the Ukrainian Registry of NBS and information from treating physicians, obtained using a developed questionnaire, were utilized for analysis.ResultsAmong 84 NBS patients, 55 (65.5%) were alive, 25 (29.8%) deceased, and 4 were lost to follow-up. The median age of patients was 11 years, ranging from 1 to 34 years. Most patients originate from western regions of Ukraine (57.8%), although in recent years, there has been an increase in diagnoses from central and southeastern regions, expanding our knowledge of NBS prevalence. The number of diagnosed patients per year averaged 3.4 and increased from 2.7 to 4.8 in recent years. The median age of NBS diagnosis was 4.0 years (range 0.1-16) in 1999-2007 and decreased to 2.7 in the past 6 years. Delayed physical development was observed in the majority of children up to the age of ten years. All children experienced infections, and 41.3% of them had recurrent infections. Severe infections were the cause of death in 12%. The second most common clinical manifestation of NBS was malignancies (37.5%), with the prevalence of lymphomas (63.3%). Malignancies have been the most common cause of death in NBS patients (72% of cases). Decreased levels of CD4+ and CD19+ were observed in 89.6%, followed by a reduction of CD3+ (81.8%) and CD8+ (62.5%). The level of NK cells was elevated at 62.5%. IgG concentration was decreased in 72.9%, and IgA - in 56.3%. Immunoglobulin replacement therapy was administered to 58.7% of patients. Regular immunoglobulin replacement therapy has helped reduce the frequency and severity of severe respiratory tract infections.ConclusionImprovements in diagnosis, including prenatal screening, newborn screening, monitoring, and expanding treatment options, will lead to better outcomes for NBS patients.
Causal association of genetically determined plasma metabolites with osteoarthritis: a two-sample Mendelian randomization study
Authors: Fu Qingsong , Yuan Xinhua , Wang Weibin , Han Xinyou , Zhang Jiakai , Wu Junlong , Wang Yao 
Published: June 2024

BackgroundWe aimed to elucidate the causal relationship between plasma metabolites and the vulnerability to Osteoarthritis (OA), encompassing both hip OA and knee OA.MethodsWe conducted a two-way two-sample Mendelian randomization (MR) analysis to investigate the association of 1,400 plasma metabolites with OA. The Inverse Variance Weighted (IVW) model served as the primary two-sample MR Analysis method, with supplementary analysis using the Weighted Median (WM) and MR Egger methods. To ensure the robustness of our findings, sensitivity analyses were performed, incorporating Cochran’s Q test, MR-Egger intercept test, MR-PRESSO, and Leave-One-Out analyses. To validate the identified metabolites, we utilized the Steiger test and linkage disequilibrium score regression.ResultsA total of 94 plasma metabolites were associated with osteoarthritis, with 60 associated with hip OA and 106 associated with knee OA. IVW analysis revealed that tryptophan levels showed the strongest positive association with hip OA (OR [95% CI]: 1.119 [1.024, 1.223]), while X-24757 levels exhibited the highest positive association with knee osteoarthritis (OR [95% CI]: 1.095 [1.032, 1.162]). Ethylparaben sulfate levels were found to have the greatest positive association with hip OA (OR [95% CI]: 1.118 [1.015, 1.231]). Notably, the plasma metabolite X-2475 showed a strong robust random effect across all three types of osteoarthritis. Metabolic pathway analysis revealed that the pathogenesis of osteoarthritis in the hip was mediated by acetylarginine, specifically in four important metabolic pathways: ethanol degradation (p = 0.044), amino sugar metabolism (p = 0.090), fatty acid biosynthesis (p = 0.095), and aspartate metabolism (p = 0.097816).ConclusionThere is a significant association between tryptophan levels and the risk of hip OA, as well as X-24757 levels and the risk of knee osteoarthritis. Additionally, X-24757 levels are also linked to the risk of hip OA. Moreover, this study has identified four crucial metabolic pathways in hip osteoarthritis, which are all regulated by acetylarginine. These findings provide valuable insights into potential biomarkers for OA and highlight potential pathways for its prevention and clinical intervention.
Mortality of neonates born to mothers of extreme reproductive age in Ethiopia; multilevel mixed effect analysis of Ethiopian demographic and health survey data of 2016
Authors: Tekeba Berhan , Techane Masresha Asmare , Workneh Belayneh Shetie , Zegeye Alebachew Ferede , Gonete Almaz Tefera , Alemu Tewodros Getaneh , Wassie Mulugeta , Kassie Alemneh Tadesse , Ali Mohammed Seid , Mekonen Enyew Getaneh , Tamir Tadesse Tarik 
Published: June 2024

IntroductionNeonatal mortality is still a major public health problem in middle- and low-income countries like Ethiopia. Despite strategies and efforts made to reduce neonatal death, the mortality rate declines at a slower pace in the country. Though there are studies conducted on neonatal mortality and its determinants, our searches of the literature have found no study on the extent of mortality of neonates born to mothers of extreme reproductive age in the study area. Therefore, this study aimed to assess the magnitude and factors associated with the mortality of neonates born to mothers of extreme reproductive age in Ethiopia.MethodsSecondary data analysis was conducted using 2016 Ethiopian Demographic and Health Survey data. The final study contained an overall weighted sample of 2,269 live births. To determine the significant factors in newborn deaths, a multilevel binary logistic regression was fitted. For measuring the clustering impact, the intra-cluster correlation coefficient, median odds ratio, proportional change in variance, and deviation were employed for model comparison. The adjusted odds ratio with a 95% confidence interval was presented in the multivariable multilevel logistic regression analysis to identify statistically significant factors in neonatal mortality. A P-value of less than 0.05 was declared statistically significant.ResultsThe neonatal mortality rate of babies born to extreme aged reproductive women in Ethiopia was 34 (95% Cl, 22.2%–42.23%) per 1,000 live birth. Being twin pregnancy (AOR = 10; 95% Cl: 8.61–20.21), being from pastoralist region (AOR = 3.9; 95% Cl: 1.71–8.09), having larger baby size (AOR = 2.93; 95% Cl: 1.4–9.12) increase the odds of neonatal mortality. On the other hand, individual level media exposure (AOR = 0.3; 95% Cl: 0.09–0.91) and community level media exposure (AOR = 0.24; 95% Cl: 0.07–0.83), being term gestation (AOR = 0.14; 95% Cl: 0.01–0.81) decreases the odds of neonatal mortality born to mothers of extreme reproductive age.ConclusionEthiopia had a greater rate of neonatal death among babies born at the extremes of reproductive age than overall reproductive life. Multiple pregnancies, larger baby sizes, emerging regions, term gestation, and media exposure were found to be significant factors associated with the mortality of neonates born to mothers of extreme reproductive age. Therefore, the concerned bodies should give emphasis to mothers giving birth before the age of 20 and above 35, access to media, healthy pregnancy, and special attention to pastoralists to reduce the burden of neonatal mortality.
Knowledge, attitude, and practice toward pediatric vitamin D deficiency among parents
Authors: Yu Chunli , Cai Jingjuan , Wang Chunxiang , Luo Yan , Fang Jian 
Published: June 2024

ObjectiveTo investigate the knowledge, attitude, and practice (KAP) towards pediatric vitamin D deficiency (VitD) among parents and explore the risk factors of their knowledge, attitude, and practice.MethodsThis cross-sectional study enrolled parents in our Hospital between November 2022 and January 2023.ResultsA total of 621 valid questionnaires were collected in this study. The knowledge, attitude, and practice scores were 6.13 ± 3.07 (theoretical score range: 0–13), 31.13 ± 6.20 (theoretical score range: 9–45), and 27.47 ± 4.21 (theoretical score range: 9–45), respectively; the mean knowledge score was &lt;60%, indicating poor knowledge. Commercial and service industry workers and a monthly income ≥5,000 CNY were independently associated with sufficient knowledge (all P &lt; 0.05). The knowledge score, ethnic minorities, divorced/widows, and spouses with a master's degree or above were independently associated with positive attitudes (all P &lt; 0.05). The attitude score, female, non-urban, undergraduate education, commercial and service industry worker, and office worker were independently associated with proactive practice (all P &lt; 0.05). Those characteristics could help design future KAP interventions on vitD deficiency.ConclusionsThis study demonstrated poor knowledge, positive attitude, and proactive practice regarding pediatric VitD deficiency among parents. Targeted interventions and educational programs should be developed to improve parental knowledge.
Assessing the long-term implications of age 9 initiation of HPV vaccination on series completion by age 13–15 in the US: projections from an age-structured vaccination model
Authors: Saxena Kunal , Patterson-Lomba Oscar , Gomez-Lievano Andres , Zion Abigail , Cunningham-Erves Jennifer , Kepka Deanna 
Published: June 2024

IntroductionRoutine human papillomavirus (HPV) vaccination in the US is recommended at ages 11 or 12 years and can be given at age 9. Vaccination completion rates among adolescents 13–15 years in the US remain below the 80% goal. This study evaluated the long-term effects of increasing proactive HPV vaccination initiation rates at age 9 years in completion rates of adolescents.MethodsAn age-structured vaccination model was developed and parametrized based on the National Immunization Survey-Teen (NIS-Teen) survey data. The model projected vaccination coverage (by vaccination status and age group), for 20 years, for a routine initiation scenario (no increase in initiation rates of 9-year-olds) and different proactive initiation (increased age 9 initiation) scenarios. The time to reach a completion rate of 80% for 13–15-year-olds was estimated. The model also generated projections stratified for subgroups of interest.ResultsResults indicated that vaccine completion rates of 80% in 13–15-year-olds may not be achieved by 2040 under current trends of routine initiation at ages 11 or 12 years. However, increasing initiation rates in 9-year-olds by 1% and 3% annually could shorten the time to achieve 80% completion by 4 and 8 years, respectively. Stratification analyses showed that increasing initiation rates in 9-year-olds can also reduce disparities across subgroups in the time to achieve vaccination completion targets.DiscussionIncreasing HPV vaccination initiation rates in 9-year-olds by as little as 1%–3% annually may be an effective strategy to improve HPV vaccination completion rates in adolescents by age 15 and reach the Healthy People goal of 80% completion much earlier.
Active monitoring of antifungal adverse events in hospitalized patients based on Global Trigger Tool method
Authors: Meng Xiao , Wu Yaozhou , Liu Zixuan , Chen Yifan , Dou Zhizhou , Wei Li 
Published: June 2024

BackgroundThe increasing prevalence of fungal infections necessitates broader use of antifungal medications. However, the prevalence of adverse drug events (ADEs) restricts their clinical application. This study aimed to develop a reliable ADEs trigger for antifungals to enable proactive ADEs monitoring, serving as a reference for ADEs prevention and control.MethodsThis investigation comprises two phases. Initially, the trigger was established via a literature review, extraction of relevant items, and refinement through Delphi expert consultation. Subsequently, the validity of the trigger was assessed by analyzing hospital records of antifungal drug users from 1 January 2019 to 31 December 2020. The correlation between each trigger signal and ADEs occurrence was examined, and the sensitivity and specificity of the trigger were evaluated through the spontaneous reporting system (SRS) and Global Trigger Tool (GTT). Additionally, risk factors contributing to adverse drug events (ADEs) resulting from antifungal use were analyzed. Results: Twenty-one preliminary triggers were refined into 21 final triggers after one expert round. In the retrospective analysis, the positive trigger rate was 65.83%, with a positive predictive value (PPV) of 28.75%. The incidence of ADEs in inpatients was 28.75%, equating to 44.58 ADEs per 100 admissions and 33.04 ADEs per 1,000 patient days. Predominant ADEs categories included metabolic disturbances, gastrointestinal damage, and skin rashes. ADEs severity was classified into 36 cases at grade 1, 160 at grade 2, and 18 at grade 3. The likelihood of ADEs increased with longer stays, more positive triggers, and greater comorbidity counts.ConclusionThis study underscores the effectiveness of the GTT in enhancing ADEs detection during antifungal medication use, thereby confirming its value as a monitoring tool.