bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclic plastic response of nickel-based superalloy at room and at elevated temperatures*
Authors: Polák Jaroslav , Petrenec Martin , Chlupová Alice , Tobiáš Jiří , Petráš Roman 
Published: February 2015

Abstract
Nickel-based cast IN 738LC superalloy has been cycled at increasing strain amplitudes at room temperature and at 800 °C. Hysteresis loops were analyzed using general statistical theory of the hysteresis loop. Dislocation structures of specimens cycled at these two temperatures were studied. They revealed localization of the cyclic plastic strain in the thin bands which are rich in dislocations. The analysis of the loop shapes yields effective stresses of the matrix and of the precipitates and the probability density function of the critical internal stresses at both temperatures. It allows to find the sources of the high cyclic stress.
Testing low-cycle material properties with micro-specimens*
Authors: Boroński Dariusz 
Published: February 2015

Abstract
New possibilities of low cycle fatigue material properties testing with the use of micro-specimens are presented in this publication. The discussed solution is of great significance for analysis of local properties of a material, e. g. in welded structures. Properties of a material determined in the manner presented in this publication find application both in fatigue life assessment (fatigue life curves) and in material modeling (cyclic stress-strain curves), e. g. in numerical analysis of local strain and stress that occur in structural components.
Cyrano de Bergerac, l'imagination et la visibilité du monde
Authors: Gipper Andreas 
Published: February 2015

Au regard de la naissance d’un nouveau discours scientifique, quelle est la relation entre la réalité et l’imagination dans la première moitié du XVII e siècle ? Quel rapport y a-t-il entre la visibilité du monde et l’intelligibilité de ses structures définie par les new sciences ? Et quel est le rôle de ce rapport pour la naissance de l’espace littéraire ? L’œuvre de Cyrano de Bergerac est particulièrement appropriée à ce genre de questionnement, puisqu’elle représente un type de littérature « baroque » qui s’approprie sans détour le discours scientifique émergent, sans pour autant opérer la dissociation entre discours scientifique et discours littéraire.
La littérarisation de la science newtonienne au XVIII e siècle : une littérature pour les dames ?
Authors: Rey Anne-Lise 
Published: February 2015

Cet article défend l’idée que, loin d’être un texte galant, le Newtonianisme pour les dames d’Algarotti est un exemple de littérarisation du savoir newtonien qui, sous couvert de rendre « sensible » la science moderne, en propose des critères d’évaluation.
Vibrations du clavecin de Diderot : des Lumières vers le marxisme et le surréalisme
Authors: Foucault Didier 
Published: February 2015

Inspiré par des médecins de son temps comme Bordeu, Diderot, dans l’ Entretien entre M. d’Alembert et M. Diderot et dans Le Rêve de d’Alembert , se sert de la métaphore des vibrations des cordes de clavecin comme alternative à la conception ancienne faisant des nerfs des vaisseaux transportant « l’esprit animal ». Dans des contextes très différents, l’instrument a continué à faire entendre les lointaines résonnances de son matérialisme. En 1909, la métaphore est reprise par Lénine dans Matérialisme et empiriocriticisme . René Crevel se la réapproprie en 1932 dans Le Clavecin de Diderot pour tenter de concilier marxisme, psychanalyse et surréalisme. En suivant le parcours de cette métaphore, cet article en évalue la force argumentative mais également la plasticité qui lui ont permis de survivre à l’effondrement de son substrat scientifique original.
Cycle économique et comportement entrepreneurial sur données régionales françaises
Authors: Aubry Mathilde , Bonnet Jean , Renou-Maissant Patricia 
Published: February 2015

Dans cet article, nous étudions les liens existants entre les créations d’entreprises, le PIB et le taux de chômage en France à partir de données régionales sur la période 1993-2011. Les interactions sont analysées tant à court terme qu’à long terme sous une double dimension : régionale et nationale. Les fluctuations du PIB représentent un indicateur avancé des créations de nouvelles entreprises au niveau national mais cet effet disparaît au niveau régional. Les créations d’entreprises et le taux de chômage se sont révélés étroitement liés aussi bien à court terme qu’à long terme et ont permis de mettre en évidence la présence des effets REFUGEE et SCHUMPETER. Dans la majorité des régions françaises l’effet REFUGEE domine à court terme : une augmentation du taux de chômage se traduit par une augmentation du nombre des créations d’entreprises. En France, les créations d’entreprises sont donc principalement impulsées par des motifs de nécessité.
FACTORS INFLUENCING ADHERENCE TO IMATINIB IN INDIAN CHRONIC MYELOID LEUKEMIA PATIENTS: A CROSS-SECTIONAL STUDY
Authors: Kapoor Jyotsna , Agrawal Narendra , Ahmad Rayaz , Sharma Sanjeev Kumar , Gupta Anshul , Bhurani Dinesh 
Published: February 2015

Adherence to imatinib(IM) is of utmost importance in patients with chronic myeloid leukemia(CML) to maximise treatment effectiveness. The main objective is to measure adherence to IM & to evaluate individual patient characteristics, personal, treatment related & psychological factors influencing adherence behaviour. Hundred patients receiving IM were analysed for adherence behaviour using 9 item Morisky Medication Adherence Scale (9-MMAS) . Various factors were assessed for their impact on adherence behaviour. These factors were age, gender, duration of treatment, frequency & dosing of treatment, use of tobacco & alcohol, educational qualification,employment status,monthly income, side effects, financial assistance in treatment, social support, knowledge about medicine & disease, concomitant drug burden, polypharmacy, physician patient interaction, patient educational sessions & prevalence of depression. Seventy five percent of patients were found to be adherent. On univariate analysis, prevalence of depression (p<0.000001), moderate severe depression (p<0.000001), concomitant drug burden (p=0.036) & monthly income (p=0.015) were found to be significantly influencing adherence. The final multivariate model retained prevalence of depression with OR= 10.367 (95% CI, 3.112- 34.538) as independent predictor of adherence to therapy. This study suggests that identification & treatment of depression among CML patients may further enhance adherence to IM therapy.Keywords: Chronic Myeloid Leukemia, Adherence, Imatinib, Nine Item Morisky Medication Adherence Scale, Patient Health Questionnaire -9.
A High-Intensity, Intermittent Exercise Protocol and Dynamic Postural Control in Men and Women
Authors: Whyte Enda , Burke Aoife , White Elaine , Moran Kieran 
Published: February 2015

ContextDeficits in dynamic postural control predict lower limb injury. Differing fatiguing protocols negatively affect dynamic postural control. The effect of high-intensity, intermittent exercise on dynamic postural control has not been investigated.ObjectiveTo investigate the effect of a high-intensity, intermittent exercise protocol (HIIP) on the dynamic postural control of men and women as measured by the Star Excursion Balance Test (SEBT).DesignDescriptive laboratory study.SettingUniversity gymnasium.Patients or Other ParticipantsTwenty male (age = 20.83 ± 1.50 years, height = 179.24 ± 7.94 cm, mass = 77.67 ± 10.82 kg) and 20 female (age = 20.45 ± 1.34 years, height = 166.08 ± 5.83 cm, mass = 63.02 ± 6.67 kg) athletes.Intervention(s)We recorded SEBT measurements at baseline, pre-HIIP, and post-HIIP. The HIIP consisted of 4 repetitions of 10-m forward sprinting with a 90° change of direction and then backward sprinting for 5 m, 2 repetitions of 2-legged jumping over 5 hurdles, 2 repetitions of high-knee side stepping over 5 hurdles, and 4 repetitions of lateral 5-m shuffles. Participants rested for 30 seconds before repeating the circuit until they reported a score of 18 on the Borg rating of perceived exertion scale.Main Outcome Measure(s)A mixed between- and within–subjects analysis of variance was conducted to assess time (pre-HIIP, post-HIIP) × sex interaction effects. Subsequent investigations assessed the main effect of time and sex on normalized maximal SEBT scores. We used intraclass correlation coefficients to determine the test-retest reliability of the SEBT and paired-samples t tests to assess the HIIP effect on circuit times.ResultsWe found a time × sex effect (F8,69 = 3.5; P range, &lt;.001–.04; η2 range, 0.057–0.219), with women less negatively affected. We also noted a main effect for time, with worse normalized maximal SEBT scores postfatigue (F8,69 = 22.39; P &lt; .001; η2 range, 0.324–0.695), and for sex, as women scored better in 7 SEBT directions (F8,69 = 0.84; P range, &lt;.001–008; η2 range, 0.088–0.381). The intraclass correlation coefficients demonstrated high (0.77–0.99) test-retest repeatability. Paired-samples t tests demonstrated increases in circuit time post-HIIP (P &lt; .001).ConclusionsThe HIIP-induced fatigue negatively affected normalized maximal SEBT scores. Women had better scores than men and were affected less negatively by HIIP-induced fatigue.
Jean Genet et l’homosexualité dans la presse étasunienne, 1959-1974
Authors: Jones David Andrew 
Published: February 2015

La sexualité libre des personnages de Jean Genet a fait de ses romans des textes clés dans le développement des études queer depuis une vingtaine d’années. Genet a pourtant écrit ces romans pendant les années 1940 et ils ont été publiés en anglais pendant les années 1960. Si l’on connaît la réception contemporaine des oeuvres de Genet comme textes queer, on connaît moins bien leur première réception comme textes avec des thèmes et personnages homosexuels parmi ses lecteurs en Amérique anglophone. Le mouvement homophile en était à ses débuts pendant les années 1950 et 1960 aux États-Unis, et on cherchait des exemples d’homosexualité dans l’histoire et dans la littérature. La lecture de Genet a donc dû compter beaucoup à cette époque pour les premiers hommes et femmes à déclarer ouvertement que leur sexualité ne se conformait pas aux normes. Le journal homophile dans lequel les romans de Genet ont reçu la plus grande attention est One : The Homosexual Viewpoint. La lecture des comptes rendus de ses romans dans One aussi bien que des entretiens et comptes rendus dans la presse à plus grande diffusion nous permettra de comprendre l’importance de Genet comme auteur de l’homosexualité pendant la période où l’idée d’une identité homosexuelle était en train de se former.
Uterus Transplant in Women With Absolute Uterine-Factor Infertility
Authors: Testa Giuliano , McKenna Greg J. , Wall Anji , Bayer Johanna , Gregg Anthony R. , Warren Ann Marie , Lee Seung Hee S. , Martinez Eric , Gupta Amar , Gunby Robert , Johannesson Liza 
Published: August 2024

ImportanceUterus transplant in women with absolute uterine-factor infertility offers the possibility of carrying their own pregnancy.ObjectiveTo determine whether uterus transplant is feasible and safe and results in births of healthy infants.Design, Setting, and ParticipantsA case series including 20 participants with uterine-factor infertility and at least 1 functioning ovary who underwent uterus transplant in a large US tertiary care center between September 14, 2016, and August 23, 2019.InterventionThe uterus transplant (from 18 living donors and 2 deceased donors) was surgically placed in an orthotopic position with vascular anastomoses to the external iliac vessels. Participants received immunosuppression until the transplanted uterus was removed following 1 or 2 live births or after graft failure.Main Outcomes and MeasuresUterus graft survival and subsequent live births.ResultsOf 20 participants (median age, 30 years [range, 20-36]; 2 Asian, 1 Black, and 16 White), 14 (70%) had a successful uterus allograft; all 14 recipients gave birth to at least 1 live-born infant. Eleven of 20 recipients had at least 1 complication. Maternal and/or obstetrical complications occurred in 50% of the successful pregnancies, with the most common being gestational hypertension (2 [14%]), cervical insufficiency (2 [14%]), and preterm labor (2 [14%]). Among the 16 live-born infants, there were no congenital malformations. Four of 18 living donors had grade 3 complications.Conclusions and RelevanceUterus transplant was technically feasible and was associated with a high live birth rate following successful graft survival. Adverse events were common, with medical and surgical risks affecting recipients as well as donors. Congenital abnormalities and developmental delays have not occurred to date in the live-born children.Trial RegistrationClinicalTrials.gov Identifier: NCT02656550
Evolution of obligate asexuality in termites with mixed‐sex societies
Authors: Yashiro Toshihisa 
Published: August 2024

AbstractMales are a ubiquitous feature of animals and play crucial roles beyond the contribution of gametes in some species (e.g., paternal care for offspring and nuptial gifts for females). In termites, colonies commonly consist of both male and female reproductives, workers, and soldiers (i.e., mixed‐sex societies), where males and females both play critical roles beyond reproduction (e.g., brood care, foraging, nest construction and maintenance, and colony defense). Male‐specific roles may also exist in termite colonies. While obligate asexuality had not been observed in any termite population until recently, all‐female asexual populations of the termite Glyptotermes nakajimai were reported in 2018. This was the first and only known case of evolutionary transition from mixed‐sex to all‐female asexual societies in animals. Here, asexual reproduction in termites is first reviewed, followed by a discussion of how and why G. nakajimai evolved obligate asexuality. The study of the evolution of obligate asexuality in termites with mixed‐sex societies is important because it may enhance our understanding of the significance of males in animal societies and populations.
T cell Dissimilarities in B Cell Activating Factor–Deficient Versus B Cell Activating Factor Receptor 3–Deficient Systemic Lupus Erythematosus‐Prone NZM 2328 Mice as Contributors to Their Divergent Clinical Outcomes
Authors: Stohl William , Wu Ying , Stohl Malka 
Published: August 2024

ObjectiveWe assessed the contributions of B cell and T cell subsets to the disparate clinical outcomes in NZM.Baff−/− and NZM.Br3−/− mice.MethodsWe assessed in NZM wild‐type, NZM.Baff−/−, and NZM.Br3−/− mice numbers and percentages of B cells and subsets, T cells and subsets, and in vivo proliferation and survival of forkhead box P3 (Foxp3)+ cells by fluorescence‐activated cell sorting. Relationships between percentages of Foxp3+ cells and numbers of CD19+ and CD4+ cells were assessed by linear regressions.ResultsIn each age and sex cohort, percentages and numbers of CD19+ cells were similar in NZM.Baff−/− and NZM.Br3−/− mice. Percentages of CD3+ and CD4+ cells were greater in NZM.Br3−/− than in NZM.Baff−/− mice, with the CD4 to CD3 cell ratios being greater in NZM.Br3−/− than in NZM.Baff−/− mice and percentages of Foxp3+ cells in NZM.Br3−/− mice being lower than in NZM.Baff−/− mice. Percentages of Foxp3+ cells correlated positively with CD19+ cells in NZM.Baff−/− mice but negatively in NZM.Br3−/− mice. In vivo proliferation and survival of Foxp3+ cells were lower in NZM.Baff−/− mice than in NZM.Br3−/− mice.ConclusionDifferences between NZM.Baff−/− and NZM.Br3−/− mice in Foxp3+ cells and their relationships with CD19+ cells may have more to do with their divergent clinical outcomes than do differences in numbers of B cells. These unexpected findings suggest that B cell activating factor (BAFF)–B cell maturation antigen (BCMA) or BAFF–Transmembrane activator and calcium‐modulator and cyclophilin ligand interactor (TACI) interactions may help drive development of clinical systemic lupus erythematosus (SLE) even under conditions of considerable B cell depletion. Insufficient blocking of BAFF–BCMA and BAFF–TACI interactions may lie at the heart of incomplete clinical response to BAFF‐targeting agents in human SLE.
Nanopores‐templated CNT/PDMS Microcolumn Substrate for the Fabrication of Wearable Triboelectric Nanogenerator Sensors to Monitor Human Pulse and Blood Pressure
Authors: Zhang Tao , Yao Chuanjie , Xu Xingyuan , Liu Zhibo , Liu Zhengjie , Sun Tiancheng , Huang Shuang , Huang Xinshuo , Farah Shady , Shi Peng , Chen Hui‐jiuan , Xie Xi 
Published: August 2024

AbstractCardiovascular diseases, which cause ≈10 million deaths annually, underscored the importance of effective blood pressure (BP) monitoring. Traditional devices, however, faced limitations that hindered the adoption of continuous monitoring technologies. Flexible triboelectric nanogenerator (TENG) sensors, known for their rapid response, high sensitivity, and cost‐effectiveness, presented a promising alternative. Enhancing their ability to capture weak biological signals can be achieved by optimizing the material's friction coefficient and expanding the effective contact area. In this work, a flexible microcolumn‐based TENG sensor with high sensitivity is developed by fabricating microcolumns of carbon nanotube/polydimethylsiloxane (CNT/PDMS) composites on porous polyethylene terephthalate (PET) membranes using template etching and integrating these with fluorinated ethylene propylene (FEP) film. With the enhancement of microcolumn structure, the sensor possessed high sensitivity and good response, enabling it to effectively and accurately detect subtle physiological changes such as radial pulses and fingertip pulsations, with pulse wave signals highly consistent with the interbeat intervals of electrocardiograms. Leveraging these capabilities, a non‐invasive dynamic BP monitoring system capable of continuous beat‐to‐beat BP monitoring is developed. This advancement enables easier and more effective health monitoring, empowering individuals to better manage their health and improve personalized medical care.
Lightweight ViT with Multiscale Feature Fusion for Driving Risk Rating Warning System
Authors: Tang Hao , Xu Xixi , Xu Haiyang , Liu Shuang , Ji Jie , Qiu Chengqun , Shen Yujie 
Published: August 2024

AbstractAddressing the issue of inadequate dynamic object detection accuracy in current road driving warning systems, this study proposes the RepBF‐YOLOv8 detection algorithm aimed at efficient risk identification. The backbone network of YOLOv8n is replaced with the lightweight RepViT architecture, which is more suitable for visual tasks. This replacement simplifies the traditional structure, reduces the complexity of the backbone network, maximizes performance enhancement, and minimizes latency. Additionally, the FPN in the neck section is upgraded to Bi‐FPN, which reduces nodes and span connections and incorporates rapid normalization to achieve fast multi‐scale feature fusion. For risk grading, the algorithm infers distances and collision times, categorizing detected objects into high, medium, and low‐risk levels, and uses different colors to warn the driver. Comparative experimental results show that the optimized algorithm improves Precision by 1.7%, Recall by 2.3%, mAP@0.5 by 1.53%, and mAP@0.5:0.95 by 2.91%. In road tests, the risk warning system achieves a frame detection rate ranging from a minimum of 38.4 fps to a maximum of 59.0 fps. The detection confidence for various objects remains above 0.71, reaching as high as 0.98. Specifically, the “Car” confidence ranges from 0.81 to 0.98, demonstrating the accuracy and robustness of vehicle risk detection.
Discovery of Potent Degraders of the Dengue Virus Envelope Protein
Authors: Li Zhengnian , Liu Han‐Yuan , He Zhixiang , Chakravarty Antara , Golden Ryan P. , Jiang Zixuan , You Inchul , Yue Hong , Donovan Katherine A. , Du Guangyan , Che Jianwei , Tse Jason , Che Isaac , Lu Wenchao , Fischer Eric S. , Zhang Tinghu , Gray Nathanael S. , Yang Priscilla L. 
Published: August 2024

AbstractTargeted protein degradation has been widely adopted as a new approach to eliminate both established and previously recalcitrant therapeutic targets. Here, it is reported that the development of small molecule degraders of the envelope (E) protein of dengue virus. Two classes of bivalent E‐degraders are developed by linking two previously reported E‐binding small molecules, GNF‐2, and CVM‐2‐12‐2, to a glutarimide‐based recruiter of the CRL4CRBN ligase to effect proteosome‐mediated degradation of the E protein. ZXH‐2‐107 (based on GNF‐2) is an E‐degrader with ABL inhibitory activity while ZXH‐8‐004 (based on CVM‐2‐12‐2) is a selective and potent E‐degrader. These two compounds provide proof of concept that difficult‐to‐drug targets such as a viral envelope protein can be effectively eliminated using a bivalent degrader and provide starting points for the future development of a new class of direct‐acting antiviral drugs.
Freedom dreaming in carceral spaces: Youth care workers' imagined alternatives to anti‐Black racism in residential facilities
Authors: Nalani Andrew 
Published: August 2024

AbstractAlthough youth–adult partnerships (Y‐APs) have been linked to a wide range of positive youth and community outcomes, the possibility of Y‐AP occurrence in spaces of racialized social control such as youth residential facilities remains unknown. Rooted in a social justice and rights‐based ethos, Y‐APs represent an innovative conceptual and practice model of youth engagement that challenges longstanding patterns of control that characterize adult‐youth relationships in these settings. This study uses narrative thematic inquiry and counter storytelling to examine frontline youth care workers' narratives (N = 21) of Y‐AP enactment against the backdrop of anti‐Black racism in youth residential facilities. Workers' narratives include instances of both enhanced and diminished forms of partnership, and explanations for Y‐AP diminishment depict an interplay of racist (anti‐Black) ideologies and organizational processes, including selective racial cognizance in hiring practices, color‐evasive and elitist training, and racialized blame‐shifting. Importantly, workers' narratives suggest that although flourishing Y‐APs remain elusive, it is not a foregone conclusion that Y‐APs cannot occur to realize youth development and social change in these extreme contexts.
Screening fluoreszenter RNA‐Methyltransferase‐Sonden im Nanomolmaßstab ermöglicht die Entdeckung von METTL1‐Inhibitoren
Authors: Meidner J. Laurenz , Frey Ariane F. , Zimmermann Robert A. , Sabin Mark O. , Nidoieva Zarina , Weldert Annabelle C. , Hoba Sabrina N. , Krone Mackenzie W. , Barthels Fabian 
Published: August 2024

AbstractDie Methylierung von RNA ist ein Stoffwechselprozess, der für seine Verbindung zu verschiedenen Krankheiten bekannt geworden ist. Darum gewinnen RNA‐Methyltransferasen (MTasen) in der Arzneistoffentwicklung zunehmend an Bedeutung. Die gängigsten RNA‐MTase‐Assays sind jedoch in ihrem Durchsatz begrenzt, was die Entwicklung im dynamischen Forschungsfeld der medizinischen Chemie verlangsamt. In dieser Studie präsentieren wir ein modulares Synthesesystem im Nanomolmaßstab, dass die Identifizierung maßgeschneiderter, fluoreszenter MTase‐Sonden ermöglicht, um eine breite Auswahl von MTasen für fluoreszenzbasierte Bindungsassays zu erschließen. Die Sondenkandidaten wurden zunächst im 4‐Nanomolmaßstab synthetisiert und konnten direkt aus der unbehandelten Reaktionsmischung getestet werden, um eine schnelle Identifizierung von optimierten Sonden zu ermöglichen. Mithilfe einer Alkin‐Azid‐Click‐Funktionalisierungsstrategie und einer in silico protein databank (PDB) Suche haben wir eine Auswahl fluoreszenter Sonden entwickelt, die für krankheitsassoziierte MTasen aus den METTL‐ und NSUN‐Familien sowie für weitere bakterielle und virale MTasen Eignung zeigen. Basierend auf diesem Konzept wurden bei einem Hochdurchsatz‐Screening des bisher unerforschten Wirkstoffziels METTL1 drei Trefferverbindungen mit mikromolarer Wirkpotenz entdeckt, die einen vielversprechenden Ausgangspunkt für die Erforschung von künftigen METTL1‐Wirkstoffen darstellen.