bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of ultrasound‐detected asymptomatic long‐term central vein catheter‐related thrombosis and fibrin sheath in cancer patients
Authors: Boddi Maria , Villa Gianluca , Chiostri Marco , De Antoniis Francesco , De Fanti Ilaria , Spinelli Alessandra , Savino Andrea , Gensini Gian Franco , Pelagatti Cecilia 
Published: January 2015

AbstractBackgroundMost central venous catheter (CVC)‐related deep vein thromboses (DVT) are asymptomatic and their incidence and clinical relevance are still under debate. Data on CVC‐related fibrin sheaths are scarce. We investigated the incidence of asymptomatic DVT and fibrin sheaths in cancer patients with long‐term CVC implantation who underwent Doppler ultrasound surveillance at 1, 6, and 12 months after implantation. Effects of low‐weight molecular heparin (LWMH) therapy on DVT and fibrin sheaths were also analyzed.Material and methodsThis prospective study was performed on a large cohort (n = 400) of patients with cancer aged >18 requiring long‐term CVC implantation for chemotherapy infusion. CVC was implanted by a trained qualified staff, according to standardized protocol in a specific surgery. Patients underwent ultrasound examination at 1 and 6 months after CVC implantation to detect ‘early’ (1 month) and ‘late’ (6 months) asymptomatic DVT or fibrin sheaths incidence. Sixty‐nine patients underwent US examination also 12 months after CVC implantation.ResultsThe incidence of CVC‐related thrombosis was 0.10 events per 1000 catheter days. Anticoagulation therapy with LWMH resolved 50% of DVT, but no CVC needed removing. Incidence of new onset fibrin sheaths was 0.71 events per 1000 catheter days. Fibrin sheaths resolution occurred independently of LWMH therapy.DiscussionThe incidence of asymptomatic DVT in our patients with long‐term CVC is very low and does not represent per se an indication for removal of functioning CVC in patients with cancer. Fibrin sheaths are frequent (13%) and never associated with CVC dysfunction.ConclusionAsymptomatic DVT and fibrin sheaths do not represent per se an indication for removal of functioning CVC in cancer patients who need central vein access.
Allogeneic stem cell transplantation for refractory acute myeloid leukemia: a single center analysis of long‐term outcome
Authors: Hemmati Philipp G. , Terwey Theis H. , Na Il‐Kang , Jehn Christian F. , le Coutre Philipp , Vuong Lam G. , Dörken Bernd , Arnold Renate 
Published: January 2015

AbstractFor patients with refractory acute myeloid leukemia (AML), allogeneic stem cell transplantation (alloSCT) represents the only curative approach. We here analyzed the long‐term outcome of 131 consecutive patients with active AML, which was either primary refractory or unresponsive to salvage chemotherapy, transplanted at our center between 1997 and 2013. After a median follow‐up of 48 months for the surviving patients, disease‐free survival (DFS) at 5 yr post alloSCT was 26% (94% CI: 17–35). Relapses, most of which occurred within the first 2 yr from transplant, were the predominant cause of treatment failure affecting 48% (95%CI: 40–58) of patients, whereas non‐relapse mortality was 26% (95%CI: 20–36) at 5 yr and thereafter. A marrow blast count ≥20% before alloSCT was an independent prognosticator associated with an inferior DFS (HR: 1.58, P = 0.027), whereas the development of chronic graft‐versus‐host disease (cGvHD) predicted an improved DFS (HR 0.21, P < 0.001) and a decreased relapse incidence (HR: 0.18, P = 0.026), respectively. These results indicate that alloSCT represents a curative treatment option in a substantial proportion of patients with refractory AML. A pretransplant blast count <20% before alloSCT and the development of cGvHD are the most important predictors of long‐term disease control.
Association between diabetes and amyotrophic lateral sclerosis in Sweden
Authors: Mariosa D. , Kamel F. , Bellocco R. , Ye W. , Fang F. 
Published: January 2015

Background and purposeEnergy metabolism is altered in patients with amyotrophic lateral sclerosis (ALS) but the role of diabetes is largely unknown.MethodsA population‐based case−control study was conducted of 5108 ALS cases and 25 540 individually matched population controls during 1991–2010. Information on ALS and pre‐existing diabetes was retrieved from the Swedish Patient Register to explore the association of ALS with diabetes overall and with insulin‐dependent or non‐insulin‐dependent diabetes specifically. Variation of the association by diabetes duration and age was also studied.ResultsIn total, 224 ALS cases (4.39%) and 1437 controls (5.63%) had diabetes before the index date, leading to an overall inverse association between diabetes and ALS risk [odds ratio (OR) 0.79, 95% confidence interval (CI) 0.68–0.91]. The association was strong for non‐insulin‐dependent diabetes (OR 0.66, 95% CI 0.53–0.81) but not for insulin‐dependent diabetes (OR 0.83, 95% CI 0.60–1.15) and varied as a function of diabetes duration, with the strongest association observed around 6 years after first ascertainment of diabetes. The association was age‐specific; the inverse association was noted only amongst individuals aged 70 or older. In contrast, for younger individuals (<50 years), pre‐existing insulin‐dependent diabetes was associated with a higher ALS risk (OR 5.38, 95% CI 1.87–15.51).ConclusionsOur study suggests that there is an association between diabetes and ALS, and highlights the importance of taking into account age, insulin dependence and diabetes duration. Future studies should explore whether the association is independent of body mass index.
3‐T magnetic resonance imaging simultaneous automated multimodal approach improves detection of ambiguous visual hippocampal sclerosis
Authors: Vasta R. , Caligiuri M. E. , Labate A. , Cherubini A. , Mumoli L. , Ferlazzo E. , Perrotta P. , Lanza P. L. , Augimeri A. , Aguglia U. , Quattrone A. , Gambardella A. 
Published: January 2015

Background and purposeTo evaluate if an automatic magnetic resonance imaging (MRI) processing system may improve detection of hippocampal sclerosis (Hs) in patients with mesial temporal lobe epilepsy (MTLE).MethodsEighty consecutive patients with a diagnosis of MTLE and 20 age‐ and sex‐matched controls were prospectively recruited and included in our study. The entire group had 3‐T MRI visual assessment of Hs analysed by two blinded imaging epilepsy experts. Logistic regression was used to evaluate the performances of neuroradiologists and multimodal analysis.ResultsThe multimodal automated tool gave no evidence of Hs in all 20 controls and classified the 80 MTLE patients as follows: normal MRI (54/80), left Hs (14/80), right Hs (11/80) and bilateral Hs (1/80). Of note, this multimodal automated tool was always concordant with the side of MTLE, as determined by a comprehensive electroclinical evaluation. In comparison with standard visual assessment, the multimodal automated tool resolved five ambiguous cases, being able to lateralize Hs in four patients and detecting one case of bilateral Hs. Moreover, comparing the performances of the three logistic regression models, the multimodal approach overcame performances obtained with a single image modality for both the hemispheres, reaching a global accuracy value of 0.97 for the right and 0.98 for the left hemisphere.ConclusionsMultimodal quantitative automated MRI is a reliable and useful tool to depict and lateralize Hs in patients with MTLE, and may help to lateralize the side of MTLE especially in subtle and uncertain cases.
Biological characteristics of the hydrological landscapes in the Bay of Biscay in spring 2009
Authors: Lezama‐Ochoa Ainhoa , Grados Daniel , Lebourges‐Dhaussy Anne , Irigoien Xabier , Chaigneau Alexis , Bertrand Arnaud 
Published: January 2015

AbstractIn the present study we investigated the biogeography of macrozooplankton and fish biomass in the Bay of Biscay. In this region, we defined six different landscapes based on the hydrogeographical characteristics observed in spring 2009. We then related landscape's characteristics and environmental parameters such as light attenuation depth and chlorophyll‐a with macrozooplankton and fish acoustic biomass. Hydrodynamic structures together with coastal influences (river discharges, predation pressure and depth preference) and vertical thermohaline structure/mixing (feeding modes and ability to stay in preferred layers) appeared as the main factors determining the biological distribution. Besides, variance partitioning was used to assess the respective roles played by the hydrological environment, the geographical space and the biological environment alone, and their interactions. Results revealed that: (i) macrozooplankton and fish have a preference for different hydrogeographical landscapes; (ii) the association between hydrological conditions and geographical features, i.e. the spatial structure of the hydrological environment, plays a key role in the distribution of macrozooplankton; and (iii) prey–predator relationships have to be taken into account to provide a comprehensive characterization of habitat suitability.
Use of medications and functional dependence among Chinese older adults in a rural community: A population‐based study
Authors: Liang Yajun , Johnell Kristina , Yan Zhongrui , Cai Chuanzhu , Jiang Hui , Welmer Anna‐Karin , Qiu Chengxuan 
Published: January 2015

AimTo investigate the associations between medication use and functional dependence in Chinese older people living in a rural community.MethodsThe cross‐sectional study included 1538 participants (age ≥60 years, 59.1% women) in the Confucius Hometown Aging Project in Shandong, China. In June 2010 to July 2011, data on demographics, lifestyle factors, health history, basic activities of daily living (ADL), instrumental ADL, and use of medications were collected through interviews and clinical examinations. Functional status was categorized into no dependence, dependence only in instrumental ADL and dependence in basic ADL. Data were analyzed with multinomial logistic models controlling for potential confounders.ResultsDependence in instrumental or basic ADL was significantly associated with use of antihypertensives and hypolipidemic agents, and basic ADL dependence was also associated with use of sedatives or tranquilizers and cardiac glycosides. An increased number of concurrently used medications was significantly associated with an increased likelihood of dependence in basic ADL (P for trend = 0.016). Compared with non‐users of any medication, individuals who concurrently used three or more classes of medications had a multi‐adjusted odds ratio of 2.91 (95% confidence interval 1.02–8.28) for dependence in basic ADL.ConclusionsUse of antihypertensives, hypolipidemic drugs, cardiac glycosides and sedatives or tranquilizers, especially use of multiple classes of medications, is correlated with functional dependence among older people in rural China. Geriatr Gerontol Int 2015; 15: 1242–1248.
Geriatric oral health predicaments in New Delhi, India
Authors: Singh Abhinav , Purohit Bharathi M , Masih Nitin 
Published: January 2015

ObjectivesThe aim of the present study was to analyze geriatric oral health predicaments in India. Specifically, to assess the oral health status and treatment needs among the geriatric population attending health camps in New Delhi, Northern India.MethodsThe sample size for the cross‐sectional study comprised of 248 elderly participants aged 60 years having attended the health check‐up camps organized in New Delhi, India. The community periodontal index was used for assessment of periodontal disease. The World Health Organization's criterion was used for detection of dentition status and treatment needs. The χ2‐test was used to compare between categorical variables. The Mann–Whitney U‐test was used to compare between two groups for quantitative variables. Regression analysis was carried out to identify the factors associated with dental caries and periodontal disease status.ResultsThe mean number of affected sextants with the highest community periodontal index score of 4 was 3.54 ± 2.45. Mean decayed, missing and filled teeth score of 16.39 ± 8.97 was recorded among the elderly. Prosthetic need was noted among 206 (83.1%) participants. Age and literacy status contributed to 27% and 12% of the variance respectively in the decayed, missing and filled teeth model. (P < 0.001) Major contributory factors in the periodontal disease model for the 37%, 11% and 11% variance were age, sex and tobacco consumption (P < 0.001).ConclusionTwo striking features of the study were the high levels of unmet prosthetic needs and the extremely low utilization of dental care. There is an urgent necessity to resolve the high burden of unmet prosthetic need among the aged in India. Geriatr Gerontol Int 2016; 16: 37–45.
Going outdoors and cognitive function among community‐dwelling older adults: Moderating role of physical function
Authors: Harada Kazuhiro , Lee Sangyoon , Park Hyuntae , Shimada Hiroyuki , Makizako Hyuma , Doi Takehiko , Yoshida Daisuke , Tsutsumimoto Kota , Anan Yuya , Uemura Kazuki , Suzuki Takao 
Published: January 2015

AimsIdentifying the risk factors of cognitive impairment is essential for implementing effective prevention strategies for dementia. Previous studies have shown that the frequency of going outdoors is inversely associated with cognitive decline. Little research has examined whether the relationship between going outdoors and cognitive decline varies with physical functioning in older adults. The aim of the present study was to examine the relationship between going outdoors and cognitive function in older adults with and without physical function limitations.MethodsThe present study analyzed the data of 4450 individuals (aged 65 years or older) who participated in the Obu Study of Health Promotion for the Elderly. The measures were the Mini‐Mental State Examination (MMSE), going outdoors (at least once a week or not), self‐reported physical function limitations (with or without), and demographic and health‐related factors as potential confounders.ResultsAnalysis of covariance and post‐hoc comparisons showed that although going outdoors at least once a week was associated with higher MMSE scores among older adults with limited physical function, it was not significantly associated with the MMSE scores among older adults without limited physical function. Similarly, logistic regression analyses, stratified by physical function, showed a significant association between going outdoors and MMSE (<24 points or not) among older adults with limited physical function.ConclusionsThe results show that going outdoors less than once a week is associated with decreased cognitive function among older adults with limited physical function, but it is not associated with cognitive function among older adults without limited physical function. Geriatr Gerontol Int 2016; 16: 65–73.
Relationship between balance and dual task walking in the very elderly
Authors: Ansai Juliana Hotta , Aurichio Thais Rabiatti , Rebelatto José Rubens 
Published: January 2015

AimTo investigate the relationship between balance and dual task performance in adults aged over 80 years, and to analyze possible differences between fallers and non‐fallers in dual task performance.MethodsAn observational cross‐sectional study was carried out at the Federal University of São Carlos (Brazil). We assessed 67 community‐dwelling older adults aged over 80 years who were able to walk. The volunteers were divided into groups of fallers and non‐fallers. The one‐leg standing and tandem tests were used to assess balance. Dual task was assessed by the Timed Up and Go test, associated with a motor task (TUGT‐motor) and a cognitive task (TUGT‐cognitive). Statistical analyses were carried out, and the significance level was set at α = 5%.ResultsSignificant correlations were found between balance and dual task variables. Fallers took significantly more time and steps on both the TUGT‐motor and the TUGT‐cognitive, with no significant differences on balance tests between groups.ConclusionsRecognizing the influence of dual task walking on balance and fall risk could help health professionals to prevent falls in older adults, as well as optimize assessment and intervention planning. Geriatr Gerontol Int 2016; 16: 89–94.
Association between the disability prevention program “Secondary Preventive Services” and disability incidence among the elderly population: A nationwide longitudinal comparison of Japanese municipalities
Authors: Tomata Yasutake , Sone Toshimasa , Chou Wan‐Ting , Tsuboya Toru , Watanabe Takashi , Kakizaki Masako , Tsuji Ichiro 
Published: January 2015

AimThe aim of the present ecological study was to evaluate the relationship between the rate of participation in Secondary Preventive Services (SPS) and the incidence of disability in Japanese municipalities.MethodsWe used the national statistics data for Long‐term Care Insurance (LTCI), because all Japanese people aged ≥65 years are eligible for LTCI services depending on their functional status assessed by a national uniform standard in all municipalities. The disability incidence rate for the 2‐year period in 2009–2010 was compared among five different levels of SPS participation in 2006–2008. The primary outcome was the sum total disability incidence rate in LTCI from 2009 to 2010. The outcome was divided according to disability level into three patterns: “all levels (Support Level 1 – Care Level 5)”, “mild disability (Care Level ≤1)” and “moderate to severe disability (Care Level ≥2)”.ResultsThere was a significant inverse association between the SPS participation rate and disability incidence rate. Among 1541 municipalities, those in the highest SPS participation rate quintile (≥9.79 per 1000 elderly population) had a lower disability incidence rate for all levels than those in the lowest quintile (<1.86 per 1000 elderly population; absolute rate difference 0.6%; age‐adjusted incident rate ratio 0.94; 95% CI 0.89–0.99). This inverse association was observed for mild disability and not for moderate to severe disability.ConclusionsMunicipalities with a higher SPS participation rate have a lower incidence rate of mild disability. SPS could be an effective health policy for containing mild disability incidence among the elderly. Geriatr Gerontol Int 2016; 16: 74–80.
Development and validation of a question prompt list for parents of children with attention‐deficit/hyperactivity disorder: a Delphi study
Authors: Ahmed Rana , McCaffery Kirsten J , Aslani Parisa 
Published: January 2015

AbstractObjectivesQuestion prompt lists (QPLs) are structured lists of disease and treatment‐specific questions intended to encourage patient question‐asking during consultations with clinicians. The aim of this study was to develop a QPL intended for use by parents of children affected by attention‐deficit/hyperactivity disorder (ADHD).MethodsThe QPL content (111 questions) was derived through thematic analysis of existing ADHD‐ and QPL‐related resources. A modified Delphi method, involving a three‐round web‐based survey, was used to reach consensus about the QPL content. Thirty‐six experts were recruited into either a professional [paediatricians, child and adolescent psychiatrists, psychologists, researchers (n =28)] or non‐professional panel [parents of children diagnosed with ADHD, ADHD consumer advocates (n = 8)]. Panel members were asked to rate the importance of the QPL content using a five‐point scale ranging from ‘Essential’ to ‘Should not be included’.ResultsA total of 122 questions, including 11 new questions suggested by panellists, were rated by both panels. Of these, 88 (72%) were accepted for inclusion in the QPL. Of the accepted questions, 39 were re‐rated during two follow‐up survey rounds and 29 (74%) were subsequently accepted for inclusion. The questions covered key topics including diagnosis, understanding ADHD, treatment, health‐care team, monitoring ADHD, managing ADHD, future expectations and support and information.ConclusionsTo our knowledge, this is the first ADHD‐specific QPL to be developed and the first use of the Delphi method to validate the content of any QPL. It is anticipated that the QPL will assist parents in obtaining relevant, reliable information and empowering their treatment decisions by enhancing the potential for shared decision making with clinicians.
Evaluation of the effect of processing on cocoa polyphenols: antiradical activity, anthocyanins and procyanidins profiling from raw beans to chocolate
Authors: Bordiga Matteo , Locatelli Monica , Travaglia Fabiano , Coïsson Jean Daniel , Mazza Giuseppe , Arlorio Marco 
Published: January 2015

SummaryThe content and composition of anthocyanins and procyanidins in fermented cocoa beans (from different geographic origins: Ecuador, Cameroon, Ivory Coast, Ghana and Nigeria), roasted nibs, cocoa mass and chocolate were determined, beside the determination of the total antiradical capacity. Concerning geographic origin, cocoa beans and processed products from Ecuador showed the highest levels of anthocyanins, followed by Nigeria and Cameroon. Generally, as cocoa beans were further processed, the levels of anthocyanins and flavan‐3‐ols decreased. The largest observed losses of phenolics occurred during roasting. A progressive decreasing trend in polyphenol concentration was observed in the other processed samples as well. Despite the original content of polyphenols in raw cocoa beans, technological processes imply a significant impact on cocoa quality, confirming the need of specific optimisation to obtain high value chocolate.
Complex Interrelations of Trait Vulnerabilities in Mothers and their Infants
Authors: Gratz Kim L. , Kiel Elizabeth J. , Latzman Robert D. , Moore Sarah A. , Elkin T. David , Megason Gail C. , Tull Matthew T. 
Published: January 2015

Despite the developmental and clinical relevance of this area of inquiry, no studies have examined the interrelations of trait vulnerabilities in the affective, behavioral, and interpersonal domains between mothers and their infants. Thus, this study examined the interrelations of three trait vulnerabilities (i.e., negative affective intensity, impulsivity, and insecure attachment) between mothers and their 12‐ to 23‐month‐old infants, focusing in particular on the unique and interactive influence of these maternal trait vulnerabilities on the expression of and precursors to these traits in their infants. Mother–infant dyads (N = 101) completed several laboratory procedures, and mothers reported on their own and their infants' expressions of the trait vulnerabilities of interest. Findings from this study provide preliminary evidence for intergenerational relations between these traits and suggest that it is the confluence of trait vulnerabilities in mothers that relates to the early expression of some of these traits in infants.
Introducing seasonal influenza vaccine in low‐income countries: an adverse events following immunization survey in the Lao People's Democratic Republic
Authors: Phengxay Manilay , Mirza Sara A. , Reyburn Rita , Xeuatvongsa Anonh , Winter Christian , Lewis Hannah , Olsen Sonja J. , Tsuyuoka Reiko , Khanthamaly Viengphone , Palomeque Francisco S. , Bresee Joseph S. , Moen Ann C. , Corwin Andrew L. ,   the Lao PDR Field Epidemiology Training Cohort Team
Published: January 2015

ObjectiveIn 2012, Lao PDR introduced seasonal influenza vaccine in pregnant women, persons aged ≥50 years, persons with chronic diseases, and healthcare personnel. We assessed adverse events following immunization (AEFI).MethodsWe used a multistage randomized cluster sample design to interview vaccine recipients.FindingsBetween April and May 2012, 355 902 were vaccinated. Of 2089 persons interviewed, 261 (12·5%) reported one or more AEFI. The most commonly reported AEFIs were local reactions. No hospitalizations or deaths were reported; 16% sought medical care. Acceptance and awareness of vaccination were high.ConclusionsFollowing the introduction of seasonal influenza vaccine in Lao PDR, self‐reported adverse events were mild.