bluuebunny/crossref_metadata_2025_split huggingface dataset:
Empagliflozin ameliorates ventricular arrhythmias by inhibiting sympathetic remodeling via nerve growth factor/tyrosine kinase receptor A pathway inhibition
Authors: Jing Yuling , Ding Yanling , Fu Hengsong , Li Tao , Long Ting , Ye Qiang 
Published: July 2024

Background and aims
Sodium-glucose cotransporter 2 inhibitors (SGLT2is) can ameliorate arrhythmias; however, the mechanisms underlying their antiarrhythmic effect remain unclear. Therefore, we aimed to test the hypothesis that the SGLT2i empagliflozin (EMPA) ameliorates ventricular arrhythmias caused by myocardial infarction (MI) by inhibiting sympathetic remodeling.

Methods
Male nondiabetic Sprague–Dawley rats were divided into Sham (n = 10), MI (n = 13), low-EMPA (10 mg/kg/day; n = 13), and high-EMPA (30 mg/kg/day; n = 13) groups. Except for the Sham group, MI models were established by ligation of the left anterior descending coronary artery. After 4 weeks, the hearts were removed. Echocardiography, electrical stimulation, hematoxylin–eosin staining and Masson's staining, Western blotting, immunohistochemistry (IHC), and ELISA were performed.

Results
Except for left ventricular posterior wall thickness (LVPWT), EMPA treatment significantly ameliorated the left ventricular anterior wall thickness (LVAWT), interventricular septum thickness (IVST), left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), and left ventricular ejection fraction (LVEF) in MI rats; there was no statistical difference between the low-EMPA and high-EMPA groups. The threshold for ventricular fibrillation induction and myocardial fibrosis was significantly ameliorated in EMPA-treated rats, and there was no statistical difference between the high-EMPA and low-EMPA groups. EMPA decreased the expression of nerve growth factor (NGF), tyrosine kinase receptor A (TrkA), tyrosine hydroxylase, and growth-associated protein 43 (GAP43) in the left ventricular infarction margin myocardium of MI rats, especially in the high-EMPA group, with a statistically significant difference between the high-EMPA and low-EMPA groups. High-EMPA significantly decreased noradrenaline (NE) levels in the blood of MI rats; however, there was no statistical difference between the low-EMPA and MI groups.

Conclusion
EMPA ameliorated the occurrence of ventricular arrhythmias in MI rats, which may be related to a reduction in sympathetic activity, inhibition of the NGF/TrkA pathway, inhibition of sympathetic remodeling, and improvement in cardiac function and cardiac structural remodeling.
Innovative Strategy for The Improvement of Competences in the Area of Science
Authors: Carrasco-Acosta Marina , Guerra-Santana Mónica , Rodríguez-Pulido Josefa , Garcia-Jimenez Pilar 
Published: July 2024

Objective: To design and implement a cooperative experience in the higher education institution in a subject of the Bachelor's Degree in Chemical Engineering carried out over five academic years.

Theoretical Framework: Higher education today calls for innovation processes that facilitate the improvement of student learning.

Method: A learning experience based on the Kolb cycle and the seminar was designed and implemented. The evaluation of the experience was carried out using the Learning Oriented Assessment (LOA) model, together with a questionnaire compiling the evaluations expressed by the students, according to the Likert scale.

Results and Discussion: The results revealed that students consider that the key to learning development lies in the distribution of tasks and the ability to work actively and autonomously.

Research Implications: The practical and theoretical implications of the study are discussed, providing higher education institutions with a learning strategy to improve competences in the area of science through innovation tools.

Originality/Value: This research highlights innovative tools that favour the development of the cognitive skills of analysis, critical thought, internalization of concepts and consolidation of part of the contents of the subject, without forgetting the communicative skills and self-learning of the student.
Adaptive system of feeding.
Authors: Пономарёв Н. , Кирнос И. , Дуборезов В. 
Published: July 2024

Внедрение адаптивной системы кормления молочного скота позволяет реализовать генетический потенциал продуктивности коров и повысить рентабельность предприятий.
Introduction of an adaptive feeding system for dairy cattle allows realization of the genetic potential of cow productivity and increase farm profitability.
Lupine seeds: specifics of application.
Authors: Сорокин А. , Руцкая В. , Ляпченко В. 
Published: July 2024

Ввод в комбикорм зерна люпина и продуктов его переработки положительно сказывается на продуктивности бройлеров и кур-несушек.
Addition of lupine grain and products of its processing in compound feed has a positive effect on broiler and layer productivity.
Center of Pressure Velocity and Dynamic Postural Control Strategies Vary During Y-Balance and Star Excursion Balance Testing
Authors: Jagger Kristen L , Harper Brent 
Published: July 2024

Background Dynamic postural control (DPC) describes an individual’s ability to maintain balance within their base of support in both anticipatory and reactive balance situations and has been measured using center of pressure (COP) velocity. Common standardized DPC assessments for active adults include the modified Star Excursion Balance Test (MSEBT) and the Y-Balance Test (YBT). Hypothesis/Purpose The purpose of this study was to explore DPC during performance of the MSEBT, the YBT, and a modified version of the YBT, the MYBT. It was hypothesized that feedback from the YBT/MYBT reach indicator would enhance DPC. Study Design Cross-sectional study Methods Twenty-one participants (9 females, 12 males, mean age 24.5±1.2 years) performed three trials in each direction (anterior-AN, posteromedial-PM, and posterolateral-PL) on each balance test during one session. The YBT frame was placed atop a force plate for all testing. Frontal and sagittal plane COP velocities (COPx and COPy, respectively) were recorded throughout each trial and resultant COP (COPr) velocities were calculated. Results Significant main effects were present for test (F=4.485, p<0.001) and reach direction (F=61.594, p<0.001). Post hoc analyses for test indicated significant differences in COPy between YBT and MSEBT (p=0.034) and between MYBT and MSEBT (p<0.001), as well as significant differences in COPr between MYBT and MSEBT (p=0.002). Post hoc analyses for reach direction revealed significant differences in COPx between AN and both PM (p<0.001) and PL (p<0.001) directions, in COPy between AN and PM (p<0.001) and PL (p<0.001) directions, and COPr between AN and PL (p=0.043) directions only. Conclusion External proprioceptive feedback from the reach indicator improved DPC during the YBT and MYBT when compared to the MSEBT. Sagittal plane COP velocities were reduced when external proprioceptive feedback from the reach indicator was present, while frontal plane COP velocities were not affected in this group of participants. Level of Evidence 2b
Nonsurgical Management of Adductor-related groin pain with Ultrasound-Guided Platelet-Rich Plasma Injection and Physical Therapy in a Competitive Soccer Player: A Case Report
Authors: Zeppieri Giorgio , Smith Micheal S , Roach Ryan P. 
Published: July 2024

Introduction Adductor-related groin pain involves an injury to the common aponeurosis connecting the rectus abdominus and adductor longus to the pubis. It commonly occurs in sports that require cutting and pivoting and can result in significant loss of playing time. Platelet-Rich Plasma (PRP) is often indicated for treatment of musculoskeletal disorders and may represent an alternative treatment for patients with adductor-related groin pain. The purpose of this case report is to describe the non-surgical management of adductor-related groin pain in a competitive soccer player with a with an ultrasound (US)-guided PRP injection and physical therapy management. Case Description A 17-year-old male competitive soccer player with right-sided adductor-related groin pain was treated with an US-guided PRP and a multi-phased physical therapy regimen based on tissue healing and individual patient/criteria progression. The patient completed 12 physical therapy sessions over six weeks post PRP injection. Outcomes At the end of treatment, clinically meaningful improvements were observed in pain intensity, passive range of motion, strength (handheld dynamometry, Biodex), functional tests, psychosocial (OSPRO-YF) and patient-reported outcomes (HAGOS, LEFS). The subject returned to sport at six weeks post injection without limitation and at three months follow up, the subject reported that he had returned to 95% of his previous level of play. Discussion This case report may offer support for PRP as an alternative treatment in the management of adductor-related groin pain. Incorporation of PRP as an adjunct to physical therapy led to improvements on all outcomes that surpassed the clinical significance change criteria. Level of evidence 5
Screening for Incidence and Effect of Pelvic Floor Dysfunction in College-Aged Athletes
Authors: Salvo Charles J , Crewe Ashlie , Estes Dillon , Kroboth Jessica , Yost Celia 
Published: July 2024

Background Pelvic floor dysfunction (PFD) occurs when muscles of the pelvic floor become weakened, impaired, or experience tension leading to a variety of complications. Due to the reactive nature and high demands of many sports, athletes are at increased susceptibility and of particular interest concerning PFD. Hypothesis/Purpose The purpose of this study was to explore the prevalence of PFD among college-aged athletes, assess how PFD impacted athletic performance, and identify contributing factors for increased likelihood of PFD in athletes. Study Design Cross-Sectional Study Methods All fully active LVC NCAA Division 3 athletes were recruited for screening for PFD using the Cozean Pelvic Dysfunction Screening Protocol and were surveyed on their self-knowledge of PFD. Athletes who scored ≥ 3 on this tool completed an additional survey, created by the investigators, to identify the impact PFD had on their athletic performance and personal life and were then randomly assigned to one of three investigators to undergo a noninvasive coccygeal assessment to determine underactive, overactive, or normal pelvic floor muscle (PFM) activity. Results Fifty-three Division III male and female athletes between the ages of 18-25 years old participated in the study. Statistically significant differences were found between Cozean scores and demographic factors of age (p <0.001), gender (p <0.05), self-knowledge of PFD (p <0.001), and sport (p <0.001) among all participants that contributed to the increased likelihood of PFD. Thirteen athletes scored ≥ 3 on the Cozean with the 92.3% experiencing under/over active PFM activity and the majority indicating that PFD significantly impacted their athletic performance and quality of life. Conclusion The results indicate that older female NCAA Division III college athletes who participate in swimming and who possess self-knowledge of PFD are more likely to experience PFD. Additionally, these athletes are likely to encounter a significant impact on their athletic performance and quality of life. These results provide preliminary evidence on the need of PFD awareness and assessment among college athletes. Level of Evidence Level 3b
Effectiveness of the heart technique (THT) therapy on students' emotional disorders
Authors: Sembiring Mimpin , Tarigan Thomas Natalisa , Lumbanbatu Johannes Sohirimon , Tibo Paulinus 
Published: July 2024

Students' emotional disorders are still a source of problems in the world of education. This emotional disorder will influence their future and their adolescence itself. The other researcher has been done some therapy, but it doesn’t work enough to pretend the teenager’s emotional disorder. This research aims to offer a solution to the problem of emotional disorders, especially depression, anxiety, and panic disorders. The solution in question is an emotional therapy called The Heart Technique, which is part of hypnotherapy. The method used is a quantitative method with a quasi-experimental approach. The subjects of this research were Class XI SOS students at RK Serdang Murni Lubuk Pakam Private High School. SOS 1 class is the experimental class and SOS 2 class is the control class. Data processing was carried out using Excel and SPSS applications. The results of data processing show that the heart technique therapy is effective in reducing students' emotional disorders.
Ascorbic Acid Injection Efficacy to Increase Skin Collagen
Authors: Anggraini Eny , Damayanti Putu Ayu Asri 
Published: July 2024

The aging process can be delayed by antioxidant supplement such as ascorbic acid. It is useful for reducing oxidative stress, inflammation, and cellular aging so that older people will be fitter and happier. The methodological approach used in this study is Literature Review (LR). This literature review will investigate the effect of ascorbic acid on inflammaging. Google Scholar, Researchgate, and Mendeley were used as the search engine. The keywords were ascorbic acid & skin collagen. The effect of ascorbic acid on geriatric beta-endorphin were analyzed from 14 articles. Body homeostasis, organ systems, and other changes will reduce the functional capacity in the skin collagen. To delay the physiological process of aging, ascorbic acid potential to improve the skin collagen. The skin collagen can be improved by the effect of ascorbic acid for a better quality of aging process
Persepsi Ketidakamanan Kerja pada Karyawan Swasta: Modal Psikologis sebagai Faktor Protektif
Authors: Nisrina Hanun Iftadi  
Published: July 2024

Pembatasan mobilitas masyarakat di masa pandemi covid-19 telah menyebabkan penuruan performa ekonomi dunia. Karyawan di perusahaan swasta menjadi salah satu yang paling terdampak dengan ancaman efisiensi organisasi melalui pemutusan hubungan kerja. Sumberdaya personal menjadi faktor yang penting untuk menjaga kesehatan mental karyawan di tengah ancaman yang hadir. Penelitian ini bertujuan untuk menguji peran modal psikologis sebagai sumberdaya personal terhadap persepsi ketidakamanan kerja pada karyawan di instansi swasta. Pendekatan kuantitatif digunakan melalui pengambilan data pada 100 sampel karyawan swasta di Indonesia. Teknik analisis regresi sederhanan digunakan untuk melihat peran variabel bebas terhadap variabel tergantung. Hasil uji hipotesis mengkonfirmasi peran modal psikologis terhadap persepsi ketidakmanan kerja (p<0,05). Di mana modal psikologis mampu memprediksi ketidakamanan kerja sebesar 8,6%. Secara umum, melalui analisis tingkat ketidakamanan kerja, mayoritas responden memiliki persepsi ketidakamanan kerja yang sedang (59%) dan tinggi (11%). Maka dapat dikatakan bahwa karyawan dengan modal psikologis yang tinggi cenderung memiliki tingkat ketidakamanan kerja yang rendah.

Kata Kunci : Modal Psikologis, Ketidakamanan Kerja, Karyawan Swasta
Keterampilan Sosial dan Adiksi Internet: Peran Moderasi Durasi Penggunaan Internet
Authors: Oki Mardiawan  , Ali Mubarak  , Ayu Tuty Utami  
Published: July 2024

Penelitian ini bertujuan untuk mengkaji hubungan antara keterampilan sosial dan adiksi internet, dengan mempertimbangkan durasi penggunaan internet sebagai variabel moderator. Studi dilakukan dengan menggunakan metode kuantitatif cross-sectional, dengan melibatkan partisipan penelitian sebanyak 250 orang pemuda pengguna internet dari Kota Bandung. Pengukuran dilakukan menggunakan skala modifikasi keterampilan sosial yang dikembangkan oleh Buhrmester et al. (1988) dan skala adiksi internet yang dikembangkan oleh Chang dan Man Law (2008). Analisis data dilakukan dengan moderated regression analysis (MRA). Hasil penelitian menunjukkan bahwa keterampilan sosial tidak memiliki hubungan yang signifikan dengan adiksi internet, begitupun dengan durasi penggunaan internet tidak menunjukkan hubungan yang signifikan juga dengan adiksi internet. Selain itu, tidak ditemukan interaksi antara keterampilan sosial dan gender maupun keterampilan sosial dan durasi penggunaan internet dalam memprediksi adiksi internet.

Kata Kunci : Keterampilan Sosial, Adiksi Internet, Moderated Regression Analysis (MRA)
Awareness and Perception of Physical Activity among Nigerian Pregnant Women Attending Primary and Tertiary Health Facilities: A Comparative Study
Authors: Emmanuel GM , Adejimi AA , Ladi-Akinyemi TW , Sodeinde KJ , Oyewole OO 
Published: July 2024

Background: Despite the benefits of physical activity (PA) during pregnancy, expectant women are not meeting the exercise recommendations. This may be connected with their level of awareness, perception, and attitude to physical exercise.
Objective: To assess and compare the awareness and perception of pregnant women about PA at primary and tertiary health care facilities (PHC and THC) in a local government in Nigeria.
Methods: A comparative, cross-sectional study recruited 502 pregnant women from six selected health facilities (250 PHC vs 252 THC). Their perception and awareness of PA were assessed using an interviewer-administered questionnaire.
Results: Pregnant women accessing care in THC have a higher level of awareness than PHC attendees (60.7% vs 34.4%; p = 0.001). Women accessing care at PHC had a better perception of PA (67.2%) than women assessing care at THC 55.2% (p = 0.006). Age and occupation were significantly associated with awareness of PA among participants in PHC, while only occupation was significantly associated with THC. Age, occupation, and number of children alive were significant predictors of awareness of PA; in contrast, age, education, monthly income, and number of pregnancies were the predictors of perception of PA among the PHC participants.
Conclusion: Awareness of PA was good in the tertiary facility but poor in PHC, while perception of PA was good in both facilities. Women, irrespective of parity, should be inspired to exercise as women who habitually exercise are more likely to continue during pregnancy.
Efektivitas Jahe Dan Daun Mint Untuk Mengatasi Emesis Gravidarum Pada Ibu Hamil Trimester I
Authors: Hariyani Ervin , Safriana Rizka Esty 
Published: July 2024

Mual dan muntah atau emesis gravidarum adalah keluhan umum yang dialami ibu hamil pada trimester I, dengan gejala mual disertai muntah yang berlebihan dan biasanya terjadi pada pagi hari atau sering juga disebut morning sickness. Ibu hamil juga mengalami perubahan fisiologis yang disebabkan peningkatan hormon progesterone dan estrogen. Akibatnya ibu hamil pada trimester I sering mengalami mual bahkan muntah. Dalam menangani emesis gravidarum pada ibu hamil trimestr I dapat diobati dengan cara farmakologi dan non farmakoligi. Salah satu cara untuk menangani emesis gravidarum pada ibu hamil trimester I dengan mengkonsumsi minuman herbal seperti jahe dan daun mint. Adapun tujuan dari penelitian ini yaitu mengetahui efektivitas dari konsumsi minuman jahe dan daun mint untuk mengurangi emesis gravidarum pada ibu hamil trimester I. Metode penelitian ialah literature review dengan menggunakan database elektronik, yaitu google scholar dengan menggunakan tiga kata kunci yaitu ” emesis gravidarum”, ”jahe”, dan ”daun mint’ . Hasil ditemukan enam jurnal untuk direview. Enam jurnal menyatakan bahwa jahe lebih efektif dari pada daun mint untuk menurunkan emesis gravidarum pada ibu hamil trimester I.
Pengaruh Penyuluhan Deteksi Dini Tumbuh Kembang Terhadap Kemampuan Kader Dalam Melakukan Skrining DDTK Di Desa Sumokali Kecamatan Candi Kabupaten Sidoarjo
Authors: Nabila Faza , Triasatin Suci Aulia 
Published: July 2024

Penyuluhan adalah proses belajar untuk mengembangkan sikap positif terhadap kesehatannya. Penelitian ini bertujuan untuk mengetahui pengaruh penyuluhan deteksi dini tumbuh kembang (DDTK) terhadap kemampuan kader dalam melakukan skirining DDTK. Metode penelitian analitik dengan desain Quasi Eksperimen. Sampel sebanyak 25 orang yang memenuhi kriteria inklusi dengan teknik total sampling. Instrument penelitian menggunakan checklist. Dari hasil penelitian didapatkan bahwa kemampuan kader sebelum diberikan penyuluhan yang kompeten melakukan DDTK 20% dan tidak kompeten 80%, sedangkan kemampuan kader setelah diberikan penyuluhan yang kompeten 92% dan tidak kompeten sebanyak 8%. Analisis data menggunakan Chi Square dengan α 0,05 diperoleh hasil p value <0,05. Maka Ho ditolak yang artinya ada pengaruh penyuluhan deteksi dini tumbuh kembang terhadap kemampuan kader dalam melakukan skrining DDTK. Penyuluhan dapat membawa perubahan pada kemampuan kader dalam melakukan skrining DDTK.
Pengaruh Kualitas Audit, Profitabilitas Terhadap Manajemen Laba Dengan Good Corporate Governance (GCG) Sebagai Variabel Moderasi
Authors: Jannah Nurul Nur , Suwarno Suwarno 
Published: July 2024

Penelitian ini bertujuan untuk menguji pengaruh kualitas audit, profitabilitas terhadap manajemen laba dengan Good Corporate Governance (GCG) sebagai variabel moderasi. Populasi dalam penelitian ini adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia (BEI) pada tahun 2021. Sampel yang diperoleh yaitu 145 perusahaan. Jenis penelitian ini adalah kuantitatif dengan jenis data sekunder. Data penelitian ini diolah menggunakan alat analisis SmartPLS 4 4.0.9.3 dan metode analisis dalam penelitian ini menggunakan Structural Equation Modeling (SEM). Hasil analisis penelitian membuktikan bahwa kualitas audit tidak berpengaruh terhadap manajemen laba, profitabilitas berpengaruh terhadap manajemen laba, sedangkan pada variabel moderasi kepemilikan manajerial dan institusional tidak mampu memoderasi kualitas audit dan profitabilitas terhadap manajemen laba
إجهاد النّص القرآني بتعدّد الأوجه الإعرابية ، قراءة في التيسير والدلالة
Authors: كيطان ردام علاوي 
Published: July 2024

طَرَق علماءُ اللغةِ إعرابَ القرآن في أواخر القرن الثاني للهجرة تحصينا لكتاب الله من اللحن ، لكنَّ قسما من النُحاة وعلماء اللغة أسهبوا في طرح أكثر من وجهٍ لبعض الموارد القرآنية ، فأجهدوا النّص الشريف بتعدّد الأوجه الإعرابية ، فضلا عن إبعاد الآية الكريمة عن مدلولها ومعناها ، وفي الوقتِ ذاتهِ طرحوا تفسيرا واحدا لذلك المورد ، فنأوا بالإعراب عن المعنى ، في حين أنَّ الإعراب لصيق المعنى ، وكانَ الأولى أن يكتفوا بوجهٍ إعرابي يتلاءم والغرض الدلالي الذي أُرسلتْ من أجله الآية الكريمة.
Implementation of National Health Insurance Scheme for Civil/Public Servants in Nigeria
Authors: James Ezekiel , Sanni Felix Olaniyi , Olaiya Abiodun Paul 
Published: July 2024

Introduction: Nigeria’s health system is characterized by gross underfunding, poor stakeholder coordination, and inadequate numbers and skills of health care workers. Thus, the study assessed the factors affecting the implementation of the National Health Insurance Scheme (NHIS) in Minna, Niger State, as well as the willingness of civil/public servants to enroll in the scheme.
Methods: The study employed a descriptive research design that is also comparative. Data were collected using questionnaires and presented and analyzed using IBM-SPSS version 25.0 for Windows with the help of tables and graphs. The respondents were drawn from 10 ministries in Minna using a multi-stage sampling method.
Results: A higher percentage of respondents (85.2%) said the scheme would be able to solve the problem of funding for health care delivery. However, more than half of the respondents, 56.1%, were either unsatisfied or very unsatisfied with their salaries. Nevertheless, 82.4% expressed good health status. All the respondents (100.0%) pay for their families’ healthcare services without receiving any financial support from any other person. Out of 127 that responded to the question asking about the effects of medical bills on their monthly expenditure. Yet, the majority, 265 (81.8%), were willing to part with a percentage of their salaries to contribute to NHIS.
Conclusion: The State Government should see the willingness of the civil servants to participate in the scheme as an opportunity to commence the implementation of the scheme without further delay to enable civil servants to participate and enjoy the benefits that the scheme offers.