bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic contrast‐enhanced MRI in mice at high field: Estimation of the arterial input function can be achieved by phase imaging
Authors: Fruytier A.‐C. , Magat J. , Colliez F. , Jordan B. , Cron G. , Gallez B. 
Published: February 2013

PurposeQuantitative dynamic contrast‐enhanced MRI requires an accurate arterial input function (AIF). At high field, increased susceptibility effects and decreased longitudinal relaxivity of contrast agents lead to predominant T2* effects in blood vessels, producing a dip in signal during passage of the contrast agent bolus. This study determined phase‐derived AIFs in mice at 11.7 T.MethodsAIFs were measured in aorta/vena cava for five FBV/N mice and in iliac arteries/veins for five NMRI mice with a fast low angle shot sequence, simultaneously with tumor imaging (temporal resolution: 1.19 s). Gadoterate was injected into the tail vein as a bolus (0.286 mmol Gd/kg). An in vitro study was also performed to calculate the relationship between ΔΦ and gadolinium concentration.ResultsThe phantom system confirmed the linear relationship between measured ΔΦ and gadolinium concentration. In vivo, a dip in arterial magnitude signal made it impossible to quantify the AIF. With phase imaging, a clear quantifiable bolus peak was obtained; peak measured concentration in plasma was 4.9 ± 0.9 mM for FBV/N mice and 8.0 ± 0.6 mM for NMRI mice, close to the expected concentration of 6.8 mM.ConclusionPhase imaging seems to be an appropriate means to measure the AIF of mice at high field. Magn Reson Med 71:544–550, 2014. © 2013 Wiley Periodicals, Inc.
Accelerated isotropic sub‐millimeter whole‐heart coronary MRI: Compressed sensing versus parallel imaging
Authors: Akçakaya Mehmet , Basha Tamer A. , Chan Raymond H. , Manning Warren J. , Nezafat Reza 
Published: February 2013

PurposeTo enable accelerated isotropic sub‐millimeter whole‐heart coronary MRI within a 6‐min acquisition and to compare this with a current state‐of‐the‐art accelerated imaging technique at acceleration rates beyond what is used clinically.MethodsCoronary MRI still faces major challenges, including lengthy acquisition time, low signal‐to‐noise‐ratio (SNR), and suboptimal spatial resolution. Higher spatial resolution in the sub‐millimeter range is desirable, but this results in increased acquisition time and lower SNR, hindering its clinical implementation. In this study, we sought to use an advanced B1‐weighted compressed sensing technique for highly accelerated sub‐millimeter whole‐heart coronary MRI, and to compare the results to parallel imaging, the current‐state‐of‐the‐art, where both techniques were used at acceleration rates beyond what is used clinically. Two whole‐heart coronary MRI datasets were acquired in seven healthy adult subjects (30.3 ± 12.1 years; 3 men), using prospective 6‐fold acceleration, with random undersampling for the proposed compressed sensing technique and with uniform undersampling for sensitivity encoding reconstruction. Reconstructed images were qualitatively compared in terms of image scores and perceived SNR on a four‐point scale (1 = poor, 4 = excellent) by an experienced blinded reader.ResultsThe proposed technique resulted in images with clear visualization of all coronary branches. Overall image quality and perceived SNR of the compressed sensing images were significantly higher than those of parallel imaging (P = 0.03 for both), which suffered from noise amplification artifacts due to the reduced SNR.ConclusionThe proposed compressed sensing‐based reconstruction and acquisition technique for sub‐millimeter whole‐heart coronary MRI provides 6‐fold acceleration, where it outperforms parallel imaging with uniform undersampling. Magn Reson Med 71:815–822, 2014. © 2013 Wiley Periodicals, Inc.
A novel phenotype variant of severe congenital neutropenia caused by G6PC3 deficiency
Authors: Estévez Orlando A. , Ortega Consuelo , Tejero Ángeles , Fernández Silvia , Aguado Rocío , Aróstegui Juan I. , González‐Roca Eva , Peña José , Santamaría Manuel 
Published: February 2013

AbstractSevere congenital neutropenia type 4 (SCN4) is associated with mutations in the G6PC3 gene. To date, all patients bearing the p.Gly260Arg variant of the G6PC3 gene show heart defects. Here, we present a case of the p.Gly260Arg variant in a patient who did not have structural or functional heart anomalies. Treatment with granulocyte colony‐stimulating factor recovered the absolute neutrophil count and neutrophil functional competence. Pediatr Blood Cancer 2013; 60: E29–E31. © 2013 Wiley Periodicals, Inc.
Unmet needs of Australian and Canadian haematological cancer survivors: a cross‐sectional international comparative study
Authors: Hall Alix , Campbell H. Sharon , Sanson‐Fisher Rob , Lynagh Marita , D'Este Catherine , Burkhalter Robin , Carey Mariko 
Published: February 2013

AbstractObjectiveFew population‐based studies have assessed the needs of haematological cancer survivors or conducted international comparisons. We aimed to assess and compare the unmet needs of Australian and Canadian haematological cancer survivors.MethodsTwo cross‐sectional datasets were analysed. Survivors were recruited from population‐based cancer registries and sent a self‐report survey containing the Survivors Unmet Needs Survey. Australians were aged 18–80 years at the time of study and diagnosed in the last 3 years. Canadians were diagnosed 1–5 years prior and aged 19 years and over at diagnosis.ResultsA total of 268 Australian and 169 Canadian survivors returned a completed survey. ‘Dealing with feeling tired’ was identified as the highest concern by survivors. Country (LRχ2 = 4.0(1), p = 0.045) was associated with survivors reporting a ‘high/very high’ unmet need with ‘worry about earning money,’ with Australians reporting marginally nonsignificantly higher odds than Canadians (OR 2.1; 95% CI; 0.99, 4.3). Country was not significantly associated with any other outcome. Having a personal expense in the last month as a result of having cancer, younger age at diagnosis, female sex, vocational or other level education, and consulting a health care professional for cancer treatment or concerns about cancer in the last month were associated with multiple areas of need.ConclusionsAustralian and Canadian haematological cancer survivors were found to experience similar levels of unmet needs. Overall, haematological cancer survivors may require additional assistance in dealing with feeling tired. Copyright © 2013 John Wiley & Sons, Ltd.
Mass spectrometry‐based methods to study protein architecture and dynamics
Authors: Kaltashov Igor A. , Bobst Cedric E. , Abzalimov Rinat R. 
Published: February 2013

AbstractMass spectrometry is now an indispensable tool in the armamentarium of molecular biophysics, where it is used for tasks ranging from protein sequencing and mapping of post‐translational modifications to studies of higher order structure, conformational dynamics, and interactions of proteins with small molecule ligands and other biopolymers. This mini‐review highlights several popular mass spectrometry‐based tools that are now commonly used for structural studies of proteins beyond their covalent structure with a particular emphasis on hydrogen exchange and direct electrospray ionization mass spectrometry.
Human enteropeptidase light chain: Bioengineering of recombinants and kinetic investigations of structure and function
Authors: Smith Eliot T. , Johnson David A. 
Published: February 2013

AbstractThe serine protease enteropeptidase exhibits a high level of substrate specificity for the cleavage sequence DDDDK∼ X, making this enzyme a useful tool for the separation of recombinant protein fusion domains. In an effort to improve the utility of enteropeptidase for processing fusion proteins and to better understand its structure and function, two substitution variants of human enteropeptidase, designated R96Q and Y174R, were created and produced as active (>92%) enzymes secreted by Pichia pastoris with yields in excess of 1.7 mg/Liter. The Y174R variant showed improved specificities for substrates containing the sequences DDDDK (kcat/KM = 6.83 × 106
M−1
sec−1) and DDDDR (kcat/KM = 1.89 × 107
M−1 sec−1) relative to all other enteropeptidase variants reported to date. BPTI inhibition of Y174R was significantly decreased. Kinetic data demonstrate the important contribution of the positively charged residue 96 to extended substrate specificity in human enteropeptidase. Modeling shows the importance of the charge–charge interactions in the extended substrate binding pocket.
Nanocrystalline electroplated NiFe‐based alloys for integrated magnetic microsensors
Authors: Theis Martin , Ediger Simon , Schmitt Martin Tobias , Hoffmann Joachim‐Ernst , Saumer Monika 
Published: February 2013

AbstractThe effect of pulse plating (PF) and direct current (DC) plating on the magnetic properties and grain size of electroplated NiFe films for the application in magnetic microsensors, i.e., as integrated magnetic concentrator, has been studied. In order to further improve magnetic properties additional subsequent thermal annealing experiments were carried out with chosen films. A sulphate‐based NiFe electrolyte containing various additives operated at a pH of 3.5 and a temperature of 50 °C was used. The softmagnetic NiFe films were deposited at a thickness of >10 µm on silicon substrates with a sputtered 200 nm thick Cu seed layer and a 50 µm high photoresist mould. The composition and magnetic properties were measured by energy dispersive X‐ray spectroscopy (EDX) and vibrating sample magnetometer (VSM), respectively. The morphology was investigated by X‐ray diffraction (XRD) and transmission electron microscopy (TEM). The composition of the fabricated fcc NiFe films ranged from 3 to 42 wt% Fe with a good adhesion. The as‐plated NiFe exhibited nanocrystalline grain sizes ranging from 12 to 18 nm with a coercivity as low as 16 A m−1. It was found that the grain size is generally higher at a lower iron content. However, pulse forward (PF) plating favours a refined grain size over DC plating which can be attributed to an increased nucleation rate caused by the high pulse current densities (high overpotential). By applying a thermal annealing for 2 h at 300 °C in a vacuum oven the coercivity of NiFe samples with ∼18.5 wt% Fe could be further reduced to 6 A m−1.
Heat treatment and substrate dependant properties of titania thin films with high copper loading
Authors: Joost Urmas , Pärna Rainer , Lembinen Meeri , Utt Kathriin , Kink Ilmar , Visnapuu Meeri , Kisand Vambola 
Published: February 2013

AbstractCopper‐doped titania thin films have been prepared on SiO2/Si(100), fused‐silica and soda‐lime glass substrates by using sol–gel deposition and subsequent annealing in air atmosphere at 200–900 °C. Several experimental techniques [X‐ray photoelectron spectroscopy (XPS), wavelength dispersive X‐ray fluorescence (WDXRF), Raman spectroscopy, atomic force microscopy (AFM), UV–Vis spectroscopy, energy dispersive X‐ray analysis (EDX), photocatalytic activity measurements and hydrophilicity measurements] have been applied to characterize these films. The results demonstrate that the films prepared on SiO2/Si(100) and fused‐silica substrates start to crystallize after annealing above 300 °C, then anatase phase is formed. At 700 °C anatase content starts to decrease and from 800 °C the films consist of rutile. Annealing causes a formation of regions with increased Cu concentration, in case of titania films prepared on SiO2/Si(100) substrates. On the other hand films prepared on soda‐lime glass substrates show large sodium diffusion into the films, the crystalline nature of the films decreases during annealing and outward segregation of copper compounds does not occur. However, the surface of copper‐doped titania films on soda‐lime glass appear to be naturally hydrophilic (i.e. surface is hydrophilic without UV irradiation), water droplet contact angles as low as 4.2° were achieved. Influence of annealing time and copper‐doping to the photocatalytic activity of thin titania films was also studied by using two organic dyes as model contaminants.
Suppression of threshold voltage shifts in organic thin‐film transistors with bilayer gate dielectrics
Authors: Fukuda Kenjiro , Suzuki Tatsuya , Kobayashi Takuma , Kumaki Daisuke , Tokito Shizuo 
Published: February 2013

AbstractBias‐stress effects in pentacene thin‐film transistors (TFT) with parylene‐C and amorphous fluoropolymers as bilayer gate dielectric layers are systematically investigated. The threshold voltage shift can be controlled systematically by changing the thicknesses of the two dielectric layers. The shift is proportional to a proportion of a potential drop between parylene‐C layer to the total potential drop between gate and source electrodes, and the threshold voltage shift can be fitted to a sum of the exponential functions. Devices with optimized thicknesses of the bilayer gate dielectrics show remarkable stability under continuous gate‐bias voltage stress over long periods, demonstrating shifts in threshold voltage of less than 0.5 V after 48 h.
Elucidating elementary processes at Cu/ZnO interfaces: A microscopical approach
Authors: Zychma Andreas , Wansing Renate , Schott Vadim , Köhler Ulrich , Wöll Christof , Muhler Martin , Birkner Alexander 
Published: February 2013

AbstractDespite its enormous importance for heterogeneous catalysis, and in particular methanol synthesis, detailed information about the Cu/ZnO interface is still far from being complete. Here we present an overview of recent work carried out using different types of microscopical methods from which the complexity of the problem becomes apparent. In addition to results from transmission electron microscopy (TEM) and scanning electron microscopy (SEM) data also obtained using scanning probe techniques, in particular scanning tunneling microscopy (STM) and atomic force microscopy (AFM) are presented. Special attention is paid to the influence of elevated temperatures on the Cu/ZnO interface.
Report on an assessment experience based on ISO/IEC 29110
Authors: Takeuchi Motoko , Kohtake Naohiko , Shirasaka Seiko , Koishi Yumi , Shioya Kazunori 
Published: February 2013

SUMMARYIn January 2011, a new standard ISO/IEC 29110 was published. To evaluate effectiveness of the assessment using ISO/IEC 29110, we have performed a series of lightweight assessment. The lightweight assessment method taken in this trial was using the task checklist based on ISO/IEC 29110‐5 with the customized procedures based on ISO/IEC 15504‐2. Through the trial, we found that the lightweight assessment required little effort to the project. Moreover, we found that the lightweight assessment was an acceptable way for the project to extract issues and risks in the project and urge awareness. Regarding the one aforementioned, the lightweight assessment using ISO/IEC 29110 has two benefits. Firstly, it is useful for the readiness checking of forthcoming tasks and workproducts. Secondly, the lightweight assessment are performed iteratively and repeatedly performed several times with little effort. As mentioned earlier, lightweight assessment should be performed not for the evaluation but as a daily routine tool to obtain the actual status and performance of management and to identify the problems. In this way, the ISO/IEC 29110 lightweight assessment is useful. Copyright © 2013 John Wiley & Sons, Ltd.
Applying data mining on customer relationship management system for leisure coffee‐shop industry: a case study in Taiwan
Authors: Chiang Wen‐Yu 
Published: February 2013

AbstractThe objective of this research is to identify high‐value markets by using the data mining technologies and a new model. The well‐known Fuzzy C‐Means algorithm is applied to process the market segmentation of the customer benefit market; and a new model [based on ‘Recency–Frequency–Monetary’ (RFM) model] is applied to process customer value markets for leisure coffee‐shop industry. The results show the relationships between the two types of markets (benefit and customer value), which are presented by fuzzy and nonfuzzy association rules. These rules can be applied to customer relationship management systems for obtaining useful and high‐value markets. The results can help leisure coffee‐shop industry to acquire knowledge of customers, and to identify the explicit customer values for marketing plans. © 2013 Wiley Periodicals, Inc.This article is categorized under:

Application Areas > Business and Industry
Clinical Issues—March 2013
Authors: Denholm Bonnie , Spruce Lisa 
Published: February 2013

This MonthRepackaging medication from single‐dose vialsKey words: medication, medication repackaging, single‐dose vials, reuse, medication shortages, reducing waste.Caring for surgical patients who have subdermal implantsKey words: subdermal implants, transdermal implants, microdermal implants, piercings, body art, surgical positioning, electrosurgery.Personal protective equipment requirements for the care of patients with methicillin‐resistant Staphylococcus aureusKey words: methicillin‐resistant Staphylococcus aureus (MRSA), contact precautions, standard precautions.
A Comparison of Warming Interventions on the Temperatures of Inpatients Undergoing Colorectal Surgery
Authors: Nicholson Martha 
Published: February 2013

AbstractThis study compared the effects of two different warming interventions in the preoperative setting on the preoperative, intraoperative, and postoperative temperatures of patients undergoing colorectal surgery in an inpatient setting. The study was performed to determine whether prewarming patients for at least 30 minutes would result in postoperative temperatures of 36° C (96.8° F) or higher within 15 minutes of their arrival in the postanesthesia care unit. The results indicated that prewarming devices did not result in reduced proportions of patients who subsequently experienced hypothermia. One reason may be that all the patients were warmed with a forced‐air warming device before induction in the OR. Our study does not recommend a specific intervention for a prewarming strategy but indicates that prewarming may contribute to normothermia in the immediate postoperative period.
Spectral Feature Extraction Based on the DCPCA Method
Authors: YUDE BU , JINGCHANG PAN , BIN JIANG , FUQIANG CHEN , PENG WEI 
Published: February 2013

AbstractIn this paper, a new sparse principal component analysis (SPCA) method, called DCPCA (sparse PCA using a difference convex program), is introduced as a spectral feature extraction technique in astronomical data processing. Using this method, we successfully derive the feature lines from the spectra of cataclysmic variables. We then apply this algorithm to get the first 11 sparse principal components and use the support vector machine (SVM) to classify. The results show that the proposed method is comparable with traditional methods such as PCA+SVM.
Silicon absorption and excretion is independent of age and sex in adults
Authors: Jugdaohsingh Ravin , Sripanyakorn Supannee , Powell Jonathan J. 
Published: February 2013

Host factors influencing the absorption and excretion of Si are poorly understood, although previous murine and human studies have suggested that age, sex and oestrogen status may affect Si metabolism and thus function. Here, serum and urine samples were collected from twenty-six healthy adults at baseline and over a 6 h period following ingestion of 17·4 mg Si (orthosilicic acid) and analysed by inductively coupled plasma optical emission spectrometry. Fasting baseline serum and urinary Si concentrations were marginally higher in older adults (51–66 years old) compared with young adults (20–47 years old); however, there was no difference in the absorption of Si into serum (overall profile, rate of Si appearance, peak concentration and time to peak) between the different adult groups. The rate of elimination of Si from serum did not significantly differ with age or sex, although serum concentration at 6 h was higher in older adults and significantly correlated with age (r 0·5; P= 0·01). There were, however, no significant differences in the excretion of Si into urine (a proxy for overall uptake) between the groups, averaging approximately 45 %. Oestradiol levels did not correlate with any of the above measures of Si. Thus, overall, host age and sex did not appear to markedly influence Si absorption or excretion in human adults and no correlations were found with serum oestradiol status. The marginally higher baseline and 6 h post-dose Si levels in older adults may reflect modestly impaired renal function and/or the loss of Si from connective tissues with ageing.
BRUNN–MINKOWSKI TYPE INEQUALITIES FOR Lp MOMENT BODIES
Authors: ZHU BAOCHENG , LI NI , ZHOU JIAZU 
Published: February 2013

AbstractAbout 15 years ago, Lutwak and Zhang (E. Lutwak and G. Zhang, Blaschke–Santalo inequalities, J. Differ. Geom. 47 (1997), 1–16) introduced the notion of Lp moment bodies and established important volume inequalities for them, which were recently generalized by Haberl and Schuster (C. Haberl and E. Schuster, General Lp affine isoperimetric inequalities, J. Differ. Geom. 83 (2009), 1–26). In this paper, we establish new Brunn–Minkowski-type inequalities with respect to Blaschke Lp harmonic addition for the quermassintegrals and dual quermassintegrals of Lp moment bodies.
ON THE VANISHING OF LOCAL HOMOLOGY MODULES
Authors: HATAMKHANI MARZIYEH , DIVAANI-AAZAR KAMRAN 
Published: February 2013

AbstractLet R be a commutative Noetherian ring, is an ideal of R and M is an R-module. We intend to establish the dual of Grothendieck's Vanishing Theorem for local homology modules. We conjecture that =0 for all i>magRM. We prove this in several cases.
SINGULAR LIMITS FOR 2-DIMENSIONAL ELLIPTIC PROBLEMS INVOLVING EXPONENTIAL NONLINEARITIES WITH SUB-QUADRATIC CONVECTION TERM
Authors: BARAKET SAMI , OUNI TAIEB 
Published: February 2013

AbstractLet Ω be a bounded domain with smooth boundary in ℝ2, q∈[1,2) and x1, x2,. . .,xm ∈ Ω. In this paper we are concerned with the following type of problem:
\[ -\Delta u-\lambda|\nabla u|^q = \rho^{2}e^{u}, \]
with u = 0 on ∂ Ω. We use some nonlinear domain decomposition method to construct a positive weak solution vρ,λ in Ω, which tends to a singular function at each xi as the parameters ρ and λ tend to 0 independently.
IRREDUCIBLE HARISH CHANDRA MODULES OVER THE DERIVATION ALGEBRAS OF RATIONAL QUANTUM TORI
Authors: LIU GENQIANG , ZHAO KAIMING 
Published: February 2013

AbstractLet d be a positive integer, q=(qij)d×d be a d×d matrix, ℂq be the quantum torus algebra associated with q. We have the semidirect product Lie algebra $\mathfrak{g}$=Der(ℂq)⋉Z(ℂq), where Z(ℂq) is the centre of the rational quantum torus algebra ℂq. In this paper, we construct a class of irreducible weight $\mathfrak{g}$-modules $\mathcal{V}$α (V,W) with three parameters: a vector α∈ℂd, an irreducible $\mathfrak{gl}$d-module V and a graded-irreducible $\mathfrak{gl}$N-module W. Then, we show that an irreducible Harish Chandra (uniformaly bounded) $\mathfrak{g}$-module M is isomorphic to $\mathcal{V}$α(V,W) for suitable α, V, W, if the action of Z(ℂq) on M is associative (respectively nonzero).