bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetically Engineered Cellular Nanovesicles: Theories, Design and Perspective
Authors: Cheng Qinzhen , Li Runtan , He Yiling , Zhu Yalan , Kang Yong , Ji Xiaoyuan 
Published: July 2024

AbstractThe use of cellular nanovesicles (CNVs) is a groundbreaking innovation in biomedical applications. Both natural extracellular vesicles (EVs) and artificial cell membrane nanovesicles (AVs) have emerged as innovative CNVs, but they have limitations in therapeutic effects and targeting abilities. Challenges such as stability, immunogenicity, and drug payload capacity hinder their widespread application. Genetic engineering has matured as a widely employed modification strategy, leading to the development of genetically engineered extracellular vesicles (gEVs) and genetically engineered artificial cell membrane nanovesicles (gAVs). This review meticulously examines the diverse types and inherent characteristics of CNVs, alongside various surface engineering strategies for CNVs, with a specific focus on elucidating the attributes and detailing the preparation methods relevant to gEVs and gAVs. Furthermore, this exploration delves into the expansive landscape of biomedical applications, developmental prospects, and current challenges associated with the utilization of gEVs and gAVs. With a comprehensive approach, the primary objective is to provide insights that not only illuminate the nuanced intricacies of these nanovesicles but also pave the way for their seamless integration into clinical research and eventual translation into practical applications.
Electrochemical Nitrogen Reduction Reaction from Ab Initio Thermodynamics: Single versus Dual Atom Catalysts
Authors: Barlocco Ilaria , Spotti Matteo , Liberto Giovanni Di , Pacchioni Gianfranco 
Published: July 2024

AbstractThe electrochemical nitrogen reduction reaction (NRR) is a key process for the energy transition. Transition metal atoms atomically dispersed on a solid support represent a promising approach to the design of new catalytic materials. The interest for single‐ (SACs) and dual‐atom catalysts (DACs) is steadily growing. In general, DACs are considered more active than SACs for NRR. In this work, the complex chemistry behind NRR is investigated on a set of SACs and DACs by means of density functional theory (DFT) calculations. The results indicate that self‐interaction corrected exchange‐correlation functionals must be adopted, at variance with several studies in the literature. Furthermore, it is not possible to extrapolate results obtained on conventional extended catalytic surfaces to SACs and DACs, due to a richer scenario of possible reaction paths. In general, the results show a positive effect on the catalytic activity moving from 3d to 5d metals, and from SACs and DACs. However, if the two effects work together, that is, 5d metals in DACs, the reaction intermediates may be too strongly bound, thus resulting in reduced catalytic activity. In this respect, the fact that DACs are expected to be superior to SACs in NRR is not always verified.
Efficacy of the nasal airflow‐inducing maneuver in the olfactory rehabilitation of laryngectomy patients: A systematic review and meta‐analysis
Authors: Young Kurtis , Morden Frances T. , Blount Quinton , Johnson Austin , Kejriwal Sameer , Bulosan Hannah , Koshi Elliott J. , Abouyared Marianne , Siddiqui Farrah , Kim Jee‐Hong 
Published: July 2024

AbstractIntroductionThis is the first systematic review and meta‐analysis to investigate the effectiveness of the nasal airflow‐inducing maneuver (NAIM) in olfactory rehabilitation for total laryngectomy (TL) patients.MethodsWe conducted a systematic literature search following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines. The inclusion criteria required that patients must have undergone a TL with subsequent NAIM training for at least 2 weeks and olfactory evaluation. The impact of NAIM on olfactory outcomes compared to that at baseline was measured. Olfactory measures included the Sniffin’ Sticks Test, Smell Disk Test, Scandinavian Odor Identification Test, and Quick Odor Detection Test. The primary outcome measures were the proportion of patients with normosmia at baseline and after intervention.ResultsSeven studies from 2000 to 2023 comprising a total of 290 TL patients met the inclusion criteria. The meta‐analysis revealed that prior to intervention, the pooled proportion of patients with normosmia was 0.16 (95% confidence interval [CI]: 0.09‒0.27, p = 0.01). After intervention, the same proportion increased to 0.55 (95% CI: 0.45‒0.68, p = 0.001). Among the included patients, 88.3% were initially anosmic or hyposmic, which was reduced to 48.9% after NAIM practice, with 51.1% achieving normosmia. The percent improvement was not found to be significantly associated with the timing of intervention post‐TL (p = 0.18).ConclusionsNAIM increased the proportion of patients who achieved normosmia in TL patients. NAIM stands out as a safe, easily teachable maneuver with promising results. Further efforts are warranted to provide specific recommendations and guidelines for the use of NAIM in clinical practice.
The association between liver fibrosis score and incident dementia: A nationwide retrospective cohort study
Authors: Weinstein Galit , Schonmann Yochai , Yeshua Hanny , Zelber‐Sagi Shira 
Published: July 2024

AbstractBACKGROUNDWe assessed the relationship of liver fibrosis score with incident dementia in a large, national sample.METHODSFor this retrospective cohort study, data of dementia‐free individuals aged 40‐69 years were derived from electronic records of the largest healthcare provider in Israel. The association between liver fibrosis score (FIB‐4), assessed from routine laboratory measurements, and incident dementia was explored through multivariate cox regression models.RESULTSOf the total sample (N = 826,578, mean age 55 ± 8 years at baseline), 636,967 (77%) had no fibrosis, 180,114 (21.8%) had inconclusive fibrosis status and 9497 (1.2%) had high risk for advanced fibrosis. Over a median follow‐up of 17 years, 41,089 dementia cases were recorded. Inconclusive liver fibrosis and advanced fibrosis were associated with increased dementia risk (HR = 1.09, 95%CI: 1.07–1.11 and HR = 1.18, 95%CI: 1.10–1.27, respectively). This association remained robust through seven sensitivity analyses.CONCLUSIONSLiver fibrosis assessed through a serum‐based algorithm may serve as a risk factor for dementia in the general population.Highlights
Liver fibrosis may predict dementia diagnosis in the general population.
Inconclusive liver fibrosis was associated with 9% increased dementia risk.
Advanced liver fibrosis was associated with 18% increased dementia risk.
Findings remained robust in sensitivity analyses and after adjustments.
Admixture mapping of cognitive function in diverse Hispanic and Latino adults: Results from the Hispanic Community Health Study/Study of Latinos
Authors: Xia Rui , Jian Xueqiu , Rodrigue Amanda L. , Bressler Jan , Boerwinkle Eric , Cui Biqi , Daviglus Martha L. , DeCarli Charles , Gallo Linda C. , Glahn David C. , Knowles Emma E. M. , Moon Jee‐Young , Mosley Thomas H. , Satizabal Claudia L. , Sofer Tamar , Tarraf Wassim , Testai Fernando , Blangero John , Seshadri Sudha , González Hector M. , Fornage Myriam 
Published: July 2024

AbstractINTRODUCTIONWe conducted admixture mapping and fine‐mapping analyses to identify ancestry‐of‐origin loci influencing cognitive abilities.METHODSWe estimated the association of local ancestry intervals across the genome with five neurocognitive measures in 7140 diverse Hispanic and Latino adults (mean age 55 years). We prioritized genetic variants in associated loci and tested them for replication in four independent cohorts.RESULTSWe identified nine local ancestry–associated regions for the five neurocognitive measures. There was strong biological support for the observed associations to cognitive function at all loci and there was statistical evidence of independent replication at 4q12, 9p22.1, and 13q12.13.DISCUSSIONOur study identified multiple novel loci harboring genes implicated in cognitive functioning and dementia, and uncovered ancestry‐relevant genetic variants. It adds to our understanding of the genetic architecture of cognitive function in Hispanic and Latino adults and demonstrates the power of admixture mapping to discover unique haplotypes influencing cognitive function, complementing genome‐wide association studies.Highlights
We identified nine ancestry‐of‐origin chromosomal regions associated with five neurocognitive traits.
In each associated region, we identified single nucleotide polymorphisms (SNPs) that explained, at least in part, the admixture signal and were tested for replication in independent samples of Black, non‐Hispanic White, and Hispanic/Latino adults with the same or similar neurocognitive tests.
Statistical evidence of independent replication of the prioritized SNPs was observed for three of the nine associations, at chr4q12, chr9p22.1, and chr13q12.13.
At all loci, there was strong biological support for the observed associations to cognitive function and dementia, prioritizing genes such as KIT, implicated in autophagic clearance of neurotoxic proteins and on mast cell and microglial‐mediated inflammation; SLC24A2, implicated in synaptic plasticity associated with learning and memory; and MTMR6, implicated in phosphoinositide lipids metabolism.
Reproductive hormones in relation to white matter hyperintensity volumes among midlife women
Authors: Thurston Rebecca C. , Chang Yuefang , Wu Minjie , Harrison Emma M. , Aizenstein Howard J. , Derby Carol A. , Barinas‐Mitchell Emma , Maki Pauline M. 
Published: July 2024

AbstractINTRODUCTIONAlthough reproductive hormones are implicated in cerebral small vessel disease in women, few studies consider measured hormones in relation to white matter hyperintensity volume (WMHV), a key indicator of cerebral small vessel disease. Even fewer studies consider estrone (E1), the primary postmenopausal estrogen, or follicle‐stimulating hormone (FSH), an indicator of ovarian age. We tested associations of estradiol (E2), E1, and FSH to WMHV among women.METHODSTwo hundred twenty‐two women (mean age = 59) underwent hormone assays (E1, E2, FSH) and 3T brain magnetic resonance imaging. Associations of hormones to WMHV were tested with linear regression.RESULTSHigher E2 (B[standard error (SE)] = –0.17[0.06], P = 0.008) and E1 (B[SE] = –0.26[0.10], P = 0.007) were associated with lower whole‐brain WMHV, and higher FSH (B[SE] = 0.26[0.07], P = 0.0005) with greater WMHV (covariates age, race, education). When additionally controlling for cardiovascular disease risk factors, associations of E1 and FSH to WMHV remained.DISCUSSIONReproductive hormones, particularly E1 and FSH, are important to women's cerebrovascular health.Highlights
Despite widespread belief that sex hormones are important to women's brain health, little work has considered how these hormones in women relate to white matter hyperintensities (WMH), a major indicator of cerebral small vessel disease.
We considered relations of estradiol (E2), estrone (E1), and follicle‐stimulating hormone (FSH) to WMH in midlife women.
Higher E2 and E1 were associated with lower whole‐brain WMH volume (WMHV), and higher FSH with higher whole‐brain WMHV.
Associations of E1 and FSH, but not E2, to WMHV persisted with adjustment for cardiovascular disease risk factors.
Findings underscore the importance of E2 and FSH to women's cerebrovascular health.
A Conductive Binder Based on Mesoscopic Interpenetration with Polysulfides Capturing Skeleton and Redox Intermediates Network for Lithium Sulfur Batteries
Authors: Wang Wenqiang , Hua Lan , Zhang Yifan , Wang Gengchao , Li Chunzhong 
Published: July 2024

AbstractThe practical application of lithium‐sulfur batteries with high theoretical energy density and readily available cathode active materials is hampered by problems such as sulfur insulation, dramatic volume changes, and polysulfide shuttling. The targeted development of novel binders is the most industrialized solution to the problem of sulfur cathodes. Herein, an aqueous conductive emulsion binder with the sulfonate‐containing hard elastic copolymer core and the conjugate polymer shell, which is capable of forming a bicontinuous mesoscopic interpenetrating polymer network, is synthesized and investigated. Not only can the elastic skeleton formed by the copolymer bind the active substance under drastic volume changes, but also the rich ester and cyanide groups in it can effectively capture lithium polysulfide. Meanwhile, the conducting skeleton consisting of poly(3,4‐ethylenedioxythiophene) both provides the additional charge conduction pathways and acts as the redox intermediates, significantly accelerating the kinetic process of lithium polysulfide conversion. Based on the synergistic effect of the above mechanisms, the use of the prepared binder on the sulfur carbon cathode significantly improves the rate performance and cycle stability of lithium sulfur batteries.
Lattice Strain Engineering Boosts CO2 Electroreduction to C2+ Products
Authors: Jiao Jiapeng , Kang Xinchen , Yang Jiahao , Jia Shuaiqiang , Chen Xiao , Peng Yaguang , Chen Chunjun , Xing Xueqing , Chen Zhongjun , He Mingyuan , Wu Haihong , Han Buxing 
Published: July 2024

AbstractRegulating the binding effect between the surface of an electrode material and reaction intermediates is essential in highly efficient CO2 electro‐reduction to produce high‐value multicarbon (C2+) compounds. Theoretical study reveals that lattice tensile strain in single‐component Cu catalysts can reduce the dipole–dipole repulsion between *CO intermediates and promotes *OH adsorption, and the high *CO and *OH coverage decreases the energy barrier for C−C coupling. In this work, Cu catalysts with varying lattice tensile strain were fabricated by electro‐reducing CuO precursors with different crystallinity, without adding any extra components. The as‐prepared single‐component Cu catalysts were used for CO2 electro‐reduction, and it is discovered that the lattice tensile strain in Cu could enhance the Faradaic efficiency (FE) of C2+ products effectively. Especially, the as‐prepared CuTPA catalyst with high lattice tensile strain achieves a FEC2+ of 90.9 % at −1.25 V vs. RHE with a partial current density of 486.1 mA cm−2.
Fully Optical Control of Polarization Current Direction in a Cyanide‐Bridged Trinuclear Complex
Authors: Huang Yu‐Bo , Su Sheng‐Qun , Xu Wen‐Huang , Zheng Wen‐Wei , Gao Kai‐Ge , Ji Tian‐Chi , Zhang Xiao‐Peng , Shui Qi‐Rui , Zhou Zi‐Qi , Ikeda Taisuke , Wu Shu‐Qi , Sato Osamu 
Published: July 2024

AbstractAs a remote and non‐contact stimulus, light offers the potential for manipulating the polarization of ferroelectric materials without physical contact. However, in current research, the non‐contact write‐read (erase) process lacks direct observation through the stable current as output signal. To address this limitation, we investigated the photoinduced polarization switching capabilities of the cyanide‐bridged compound [Fe2Co] using visible light, leading to the achievement of rewritable polarization. By subjecting [Fe2Co] crystals to alternating irradiation with 785 nm and 532 nm light, the polarization changes exhibited a distinct square wave pattern, confirming the reliability of the writing and erasing processes. Initialization involved exposing specific crystal units to 532 nm light for storing “1” or “0” information, while reading was accomplished by scanning the units with 785 nm light, resulting in brief current pulses for “1” states and no current signal for “0” states. This research unveils new possibilities for optical storage systems, paving the way for efficient and rewritable data storage and retrieval technologies, such as the next‐generation memories.
High‐entropy configuration strategy boosts excellent rate performance of layered oxide for sodium‐ion batteries
Authors: Cai Qiuyun , Liu Xiangyu , Hu Haonan , Wang Pengfei , Jia Min , Zhang Xiaoyu 
Published: July 2024

AbstractLayered oxides are considered to be potential cathodes for sodium‐ion batteries based on high theoretical capacity and ease of synthesis. However, the complex phase transition caused by interlayer sliding in layered oxides leads to poor cycling stability, which will hinder their further application. Here, we designed a newly O3‐type layered cathode NaNi0.3Co0.2Cu0.1Mn0.2Ti0.2O2 based on high‐entropy to achieve highly reversible phase transition behavior. It reveals 132 mAh g−1 at 0.2 C within 2–4 V increasing the energy density to 408 Wh kg−1 and it shows an outstanding rate capability of 90 mAh g−1 at 80 C (84.90% capacity retention after 1,500 cycles at 80 C). In‐situ XRD shows that reasonable design of high‐entropy components in layered material can achieve the purpose of delaying the occurrence of phase transition and DFT calculations show that the introduction of Co in transition metal layers can effectively improve the rate performance of the material. This work is of great significance in guiding the design and synthesis of highly stable layered cathode materials for sodium‐ion batteries.
Specificity of the short‐story task for autism diagnosis when controlling for depression
Authors: Jarvers Irina , Pfisterer Johannes , Döhnel Katrin , Blaas Lore , Ullmann Manuela , Langguth Berthold , Rupprecht Rainer , Sommer Monika 
Published: July 2024

AbstractSecuring an accurate autism‐spectrum‐condition diagnosis, particularly among women, remains challenging for autistic adults. Building upon previous research highlighting the short‐story task (SST) as a promising tool for detecting fiction‐based mentalizing difficulties in autistic adults, this study expands its scope. We investigated the SST's discriminative capacity across three distinct groups: autistic individuals (n = 32), nonautistic individuals without mental health problems (n = 32), and nonautistic individuals with clinical depression (n = 30). All three groups differed significantly from each other in their SST mentalizing score with the nonautistic group having the highest scores, the nonautistic but depressed group having medium scores and the autistic group showing the lowest scores. Receiver operator curve (ROC) analysis reaffirmed the SST's efficacy as a discriminator. Moreover, a linear regression analysis identified the SST mentalizing score, the SST comprehension score, and the number of books read per month as significant predictors of autism‐spectrum‐condition diagnosis. These findings bolster the SST's potential as a valuable adjunct in autism diagnostics, highlighting its discriminatory ability across diverse samples.
Analysis of the efficacy of hyperbaric oxygen therapy for disorders of consciousness: A retrospective cohort study
Authors: Li Sha , Di Zhi‐Juan , Liu Zi‐Bo , Zhao Long , Li Man‐Yu , Li Hong‐Ling 
Published: July 2024

AbstractObjectiveTo analyze the efficacy and associated factors affecting the prognosis in patients with disturbance of consciousness after hyperbaric oxygen (HBO) treatment.MethodsA retrospective study was carried out on patients with disorders of consciousness (DOC) receiving HBO treatment from January to January 2022 in the Second Department of Rehabilitation Medicine of the Second Hospital of Hebei Medical University, China.ResultsHBO therapy improved the Glasgow Coma Scale (GCS) and Chinese Nanjing Persistent Vegetative State Scale (CNPVSS), as well as the clinical efficacy in patients with DOC. The comparison of GCS and CNPVSS scores in patients with DOC before and after HBO treatment was all statistically significant, with 325 patients (67.1%) showing effective results and 159 patients (32.9%) having unchanged outcomes. Univariate analysis indicated that there were statistically significant differences in age, HBO intervention time, HBO treatment times, pre‐treatment GCS score, and etiology and underlying diseases between the good and poor prognoses groups. Multivariate regression analysis showed that HBO intervention time ≤7 days, HBO treatment ＞ times, high GCS score before HBO treatment, and brain trauma were independent influencing factors in achieving a good prognosis for patients with DOC. Low pre‐treatment GCS scores were an independent risk factor for a poor prognosis in patients with brain trauma while being male, late HBO intervention time, fewer HBO treatment times, and low pre‐treatment GCS scores were independent risk factors for a poor prognosis in patients with DOC after a stroke. Being ≥50 years of age, late HBO intervention time, and low pre‐treatment GCS scores were independent risk factors for a poor prognosis in patients with DOC after hypoxic‐ischaemic encephalopathy.ConclusionHBO therapy can improve the GCS, CNPVSS scores and clinical efficacy in patients with DOC, and the timing of HBO intervention ≤7 days, times of HBO treatment, high pre‐treatment GCS score, and brain trauma were the independent influencing factors of good prognosis in patients with DOC.
An ecosystem orchestration framework for the design of digital product passports in a circular economy
Authors: Jensen Steffen Foldager , Kristensen Jesper Hemdrup , Christensen Andreas , Waehrens Brian Vejrum 
Published: July 2024

AbstractDigital product passports are considered key levers for a circular economy. By encouraging intraorganizational and interorganizational exchange of data and information, they enable informed life cycle decision‐making to circulate products and materials at their highest utility. This is contingent on the engagement of supply chain actors to contextualize the industrial implications in the span between regulatory compliance and additional value‐generation. Through the lens of ecosystem orchestration, this multiple case study draws upon industrial insights from three product manufacturers as well as a sample of their respective suppliers, service partners, customers, and third‐party recycling companies to identify 16 practices and five orchestration mechanisms. These unfold at different stages of ecosystem maturity. Combined, they construct a framework for the adaptation of digital product passports in industrial ecosystems. This provides guidance for practitioners throughout the contextualization and utilization of digital product passports and extends the scientific debate in the direction of operationalization. As digital product passports are still in their infancy, avenues for further research are identified, particularly concerning the operational foundations, including the adherent driving and inhibiting factors toward the implementation of digital product passports.
The effect of autonomous sensory meridian response (ASMR) messages on consumer brand perceptions and intentions
Authors: Gotsch Mauro Luis , Gasser Florian 
Published: July 2024

AbstractFor the past 10 years, a new genre of media content called ASMR has been growing rapidly in popularity. ASMR is described as a pleasurable tingling sensation usually triggered by different audio‐visual signals, performed by so‐called ASMRtists. These triggers have been shown to lead to increased parasocial identification with ASMRtists as well as a stronger commitment to their marketing messages. Yet so far, the effectiveness of ASMR marketing has not been directly compared to the effectiveness of typical influencer marketing. Using two consecutive 2 × 2 experiments among 408 consumers, this study compares the effect of a sponsorship message of two ASMRtists with two YouTube influencers. The results show that ASMR can be induced even by short, sponsored messages and that it positively influences the perception of both the advertised brand and the ASMRtist presenting it. Hence, ASMRtists are suitable brand ambassadors for marketers looking to reach an underserved online community.