bluuebunny/crossref_metadata_2025_split huggingface dataset:
To Flourish or Not: Positive Mental Health and All-Cause Mortality
Authors: Keyes Corey L. M. , Simoes Eduardo J. 
Published: September 2012

Objectives. We investigated whether positive mental health predicts all-cause mortality. Methods. Data were from the Midlife in the United States (MIDUS) study (n = 3032), which at baseline in 1995 measured positive mental health (flourishing and not) and past-year mental illness (major depressive episode, panic attacks, and generalized anxiety disorders), and linked respondents with National Death Index records in a 10-year follow-up ending in 2005. Covariates were age, gender, race, education, any past-year mental illness, smoking, physical inactivity, physical diseases, and physical disease risk factors. Results. A total of 6.3% of participants died during the study period. The final and fully adjusted odds ratio of mortality was 1.62 (95% confidence interval [CI] = 1.00, 2.62; P = .05) for adults who were not flourishing, relative to participants with flourishing mental health. Age, gender, race, education, smoking, physical inactivity, cardiovascular disease, and HIV/AIDS were significant predictors of death during the study period. Conclusions. The absence of positive mental health increased the probability of all-cause mortality for men and women at all ages after adjustment for known causes of death.
Primary Care and Public Health Services Integration in Brazil’s Unified Health System
Authors: Pinto Rogério M. , Wall Melanie , Yu Gary , Penido Cláudia , Schmidt Clecy 
Published: September 2012

Objectives. We examined associations between transdisciplinary collaboration, evidence-based practice, and primary care and public health services integration in Brazil’s Family Health Strategy. We aimed to identify practices that facilitate service integration and evidence-based practice. Methods. We collected cross-sectional data from community health workers, nurses, and physicians (n = 262). We used structural equation modeling to assess providers’ service integration and evidence-based practice engagement operationalized as latent factors. Predictors included endorsement of team meetings, access to and consultations with colleagues, familiarity with community, and previous research experience. Results. Providers’ familiarity with community and team meetings positively influenced evidence-based practice engagement and service integration. More experienced providers reported more integration and engagement. Physicians reported less integration than did community health workers. Black providers reported less evidence-based practice engagement than did Pardo (mixed races) providers. After accounting for all variables, evidence-based practice engagement and service integration were moderately correlated. Conclusions. Age and race of providers, transdisciplinary collaboration, and familiarity with the community are significant variables that should inform design and implementation of provider training. Promising practices that facilitate service integration in Brazil may be used in other countries.
ZAP-70+ B Cell Subset Influences Response to B Cell Depletion Therapy and Early Repopulation in Rheumatoid Arthritis
Authors: GREMESE ELISA , TOLUSSO BARBARA , FEDELE ANNA LAURA , CANESTRI SILVIA , ALIVERNINI STEFANO , FERRACCIOLI GIANFRANCO 
Published: September 2012

Objective.To define the role of ZAP-70+ B cells (CD19+/ZAP-70+) as a biomarker of response to B cell depletion therapy (BCDT), their relationship with clinical outcome, and their behavior during repopulation of peripheral blood in patients with rheumatoid arthritis (RA).Methods.Thirty-one patients with RA underwent BCDT and were followed for 12 months. Disease activity was assessed with the European League Against Rheumatism (EULAR) criteria. Cytofluorimetric analysis of peripheral blood B cell subsets at baseline and at 6- and 12-month intervals after BCDT was performed using surface markers (CD45, CD3, CD56, CD19, IgD, CD38, CD27) and intracellular ZAP-70.Results.A moderate/good EULAR response was achieved in 66.6% of the RA cohort. The baseline percentage of CD19+/ZAP-70+ cells was lower in good responder patients (1.8% ± 1.7%) compared to poor responders (5.6% ± 4.9%; p = 0.02). A decrease of plasmablasts (IgD-CD27+CD38+) and pre-switch memory (IgD+CD27+) B cells occurred after BCDT. Recovery of B cells in peripheral blood after the first course of BCDT was characterized by the reappearance of B cell subtypes that showed a naive, activated phenotype, coupled with a decrease in memory cells. B cells carrying intracytoplasmic ZAP-70 increased significantly from the baseline value of 4.4% ± 4.5% to 12.4% ± 9.2% (p = 0.001) at the 6-month and to 9.4% ± 6.4% (p = 0.002) at the 12-month followup.Conclusion.Baseline percentage of CD19+/ZAP-70+ cells is associated with the clinical outcome after BCDT in patients with RA. Depletion of plasmablasts and pre-switch memory B cells and increase of CD19+/ZAP-70+ cells are features of the recovery of the B cell pool after BCDT.
Giant Cell Arteritis with or without Aortitis at Diagnosis. A Retrospective Study of 22 Patients with Longterm Followup
Authors: ESPITIA OLIVIER , NÉEL ANTOINE , LEUX CHRISTOPHE , CONNAULT JÉROME , ESPITIA-THIBAULT ALEXANDRA , PONGE THIERRY , DUPAS BENOIT , BARRIER JACQUES H. , HAMIDOU MOHAMED A. , AGARD CHRISTIAN 
Published: September 2012

Objective.Studies have shown that aortitis may be present in half the patients with recent-onset giant cell arteritis (GCA). We assessed whether aortitis at diagnosis affects longterm outcome in patients with GCA.Methods.We retrospectively analyzed the longterm outcome of a prospective cohort of 22 patients with biopsy-proven GCA who all had aortic computed tomography (CT) evaluation at the time of diagnosis of GCA between May 1998 and November 1999. Longterm outcome, especially vascular events such as aortic aneurysm, mortality, relapses of GCA, and requirement for steroids, was assessed in 2011 by chart review and patient/physician interviews.Results.At disease onset, 10/22 patients had aortitis on CT scan. Patients with and without aortitis had similar baseline characteristics, including cardiovascular risk profile. At the time of the study, 12/22 (57%) patients had died. Vascular causes of death were more frequent in patients with aortitis (5/7 vs 0/5; p = 0.02). A higher number of vascular events was noted in patients with aortitis (mean events per patient 1.33 vs 0.25; p = 0.009). Stroke was more frequent in patients with aortitis. These patients seemed to exhibit a more chronic or relapsing disease course, and they were less likely to completely discontinue steroid therapy (p = 0.009, log-rank test).Conclusion.Our study suggests for the first time that inflammatory aortic involvement present at onset of GCA could predict a more chronic/relapsing course of GCA, with higher steroid requirements and an increased risk for vascular events in the long term.
La science en débat en Amérique latine
Authors: Feld Adrian , Kreimer Pablo 
Published: September 2012

Entre la fin des années 1960 et le début des années 1970 un large courant critique sur le rôle des sciences et des technologies apparaît à travers le monde. De même, en Argentine, ce mouvement s’est traduit dès 1968 et 1969 par la création d’espaces institutionnels pour le débat et la production des connaissances sur les sciences et les technologies. La confrontation d’idées a mis en évidence un processus de politisation de la science qui entraînait des sens bien différents : d’un côté, un courant « modéré » qui cherchait des outils analytiques et normatifs pour la mise en place des politiques publiques de S&T et, d’un autre côté, les « radicaux » qui impulsaient l’intégration des sciences et des technologies dans la politique tout court. Cet article propose de se concentrer sur le courant radical, dont le représentant le plus saillant fut Oscar Varsavsky, ce qui nous permet d’analyser : a) le processus de « politisation/radicalisation » de la science émergeant vers la fin des années 1960 ; b) les principaux points de confrontation entre les positions politiques et épistémologiques de Varsavsky et d’autres acteurs importants de l’époque ; c) l’émergence de nouveaux canaux de diffusion des débats sur les sciences et les technologies, comme la revue Ciencia Nueva et les échanges autour de la relation « science-idéologie » ; d) l’adoption et la réinterprétation du discours de Varsavsky de la part des organisations politico-syndicales de l’époque.
La reconfiguration du domaine de la lithotripsie extracorporelle
Authors: Arellano Hernández Antonio 
Published: September 2012

Dans ce travail, il s’agit d’avancer l’étude de la reconfiguration des collaborations dans la production de connaissances technoscientifiques, à partir d’une double approche : sur un plan conceptuel et méthodologique, on analyse la capacité épistémologique de trois approches représentatives pour aborder des mutations de la production scientifique, à savoir : l’idée de l’interdisciplinarité, celle d’objet-frontière et celle de traduction. Sur le plan empirique, on analyse les données d’une étude ethnographique d’un cas de travail collaboratif, entre une équipe de physiciens des ondes de choc et une équipe de médecins urologues, pour l’intégration d’un domaine technoscientifique nommé lithotripsie extracorporelle au regard de la capacité épistémologique de ces approches, afin d’améliorer la compréhension du travail technoscientifique collaboratif.
A Universal Volume Comparison Theorem for Finsler Manifolds and Related Results
Authors: Zhao Wei , Shen Yibing 
Published: September 2012

AbstractIn this paper, we establish a universal volume comparison theorem for Finsler manifolds and give the Berger–Kazdan inequality and Santalá's formula in Finsler geometry. Based on these, we derive a Berger–Kazdan type comparison theorem and a Croke type isoperimetric inequality for Finsler manifolds.
Paper‐Derived Bioactive Glass Tape
Authors: Stares Steferson Luiz , Kirilenko Alina , Fredel Márcio Celso , Greil Peter , Wondraczek Lothar , Travitzky Nahum 
Published: September 2012

AbstractPorous bioactive glass (BaG) structures were manufactured applying novel preceramic paper process. Preceramic papers were produced for aqueous suspensions loaded with different contents of pulp fiber and BaG filler. Pressure loading was applied in order to increase the packing density in the paper sheets. The paper sheets were sintered at 630 °C for 1 h. The porous glass–ceramic specimens were characterized for density, porosity, composition, microstructure, and mechanical properties. A pronounced volumetric shrinkage was observed, but no surface flaws or inhomogeneous areas were detected. The mechanical strength using the ball on three balls test and elastic modulus of sintered specimens vary between 21 and 33 MPa and 0.30–0.85 GPa, respectively.
Force Control of an Electrohydraulic Actuator Using a Fractional‐Order Controller
Authors: Sangpet Teerawat , Kuntanapreeda Suwat 
Published: September 2012

AbstractThis paper presents an application of fractional‐order control to industrial electrohydraulics. An optimization based frequency domain approach is used to obtain a fractional‐order proportional‐integral controller for force control of an electrohydraulic actuator. The controller is designed to have a feature of robustness to gain variations with the step responses exhibiting an iso‐damping property. In practice, the gain variations are due to the changes in the environment or the load's force interacting with the actuator. Results of real life experiments demonstrate the effectiveness of the controller.
New spectrofluorimetric method for determination of cephalosporins in pharmaceutical formulations
Authors: Ali Ahmed Shazalia M. , Elbashir Abdalla A. , Suliman Fakhr Eldin O. , Aboul‐Enein Hassan Y. 
Published: September 2012

ABSTRACTA simple, accurate, precise spectrofluorimetric method has been proposed for the determination of three cephalosporins, namely, cefixime (cefi), cephalexine (ceph), and cefotaxime sodium (cefo) in pharmaceutical formulations. This method is based on a reaction between cephalosporins with 8‐hydroxy‐1,3,6‐pyrenetrisulfonic acid trisodium salt (HPTS) in alkaline medium, at pH 12.0 for cefi and 13.0 for ceph and cefo to give highly fluorescent derivatives extracted with chloroform and subsequent measurements of the formed fluorescent products at 520, 500 and 510 nm after excitation at 480, 470 and 480 nm for cefi, ceph and cefo respectively. The optimum experimental conditions have been studied. Beer's law is obeyed over concentrations of 10–60 ng/mL, 5–35 ng/mL and 10–60 ng/mL for cefi, ceph and cefo, respectively. The detection limits were 4.20 ng/mL, 2.54 ng/mL and 4.09 ng/mL for cefi, ceph and cefo, respectively, with a linear regression correlation coefficient of 0.99783, 0.99705 and 0.9978 and recoveries in ranges 96.96–105.77, 96.13–102.55 and 95.45–105.39% for cefi, ceph and cefo, respectively. This method is simple and can be applied for the determination of cefi, ceph and cefo in pharmaceutical formulations in quality control laboratories. Copyright © 2012 John Wiley & Sons, Ltd.
Comprehensive fluorogenic derivatization–liquid chromatography/tandem mass spectrometry proteomic analysis of colorectal cancer cell to identify biomarker candidate
Authors: Koshiyama Akiyo , Ichibangase Tomoko , Imai Kazuhiro 
Published: September 2012

ABSTRACTExisting colorectal cancer biomarkers are insufficient for providing a quick and accurate diagnosis, which is critical for a good prognosis. More appropriate biomarkers are thus needed. To identify new colorectal cancer biomarker candidates, we conducted a comprehensive differential proteomic analysis of six cancer cell lines and a normal cell line, utilizing a fluorogenic derivatization–liquid chromatography–tandem mass spectrometry (FD‐LC‐MS/MS) approach. Two sets of intracellular biomarker candidates were identified: one for colorectal cancer, and the other for metastatic colorectal cancer. Our results suggest that cooperative expression of FABP5 and cyclophilin A might be linked to Her2 signaling. Upregulation of LDHB and downregulation of GAPDH suggest the existence of a specific nonglycolytic energy production pathway in metastatic colorectal cancer cells. Downregulation of 14‐3‐3ζ/δ, cystatin‐B, Ran and thioredoxin could be a result of their secretion, which then stimulates metastasis via activity in the sera and ascitic fluids. We propose a possible flow scheme to describe the dynamics of protein expression in colorectal cancer cells leading to tumor progression and metastasis via cell proliferation, angiogenesis, disorganization of actin filaments and epithelial–mesenchymal transition. Our results suggest that colorectal tumor progression may be regulated by signaling mediated by Her2, hypoxia, and TGFβ. Copyright © 2012 John Wiley & Sons, Ltd.
Transcatheter aortic valve implantation for severe regurgitation in native and degenerated bioprosthetic aortic valves
Authors: Sarkar Kunal , Sardella Gennaro , Romeo Francesco , De Benedictis Mauro , Tarsia Giandomenico , Iadanza Alessandro , Sharma Samin. K. , Barbanti Marco , Tamburino Corrado , Ussia Gian Paolo 
Published: September 2012

ObjectivesWe evaluated transcatheter aortic valve Implantation (TAVI) in high‐risk patients with severe aortic regurgitation (AR) in native or degenerated bioprosthetic valves. Background: TAVI has emerged as a viable treatment modality for severe aortic stenosis in inoperable or high‐risk patients. The use of TAVI for treatment of severe AR has remained largely unexplored.MethodsEight patients (age 79.6 years ± 5.75 years) with severe AR underwent TAVI at six tertiary hospitals between April 2010 and May 2011. All patients were considered to be at prohibitive risk for surgical aortic valve replacement (SAVR).TAVI with the nitinol based Core Valve bioprosthesis (CRS) (Medtronic) was performed in all patients.ResultsTransfemoral access was used in all cases. Procedural success was obtained in all cases without any intraprocedural complications. There was no in hospital or 30‐day mortality. There were no cases of atrioventricular blocks requiring permanent pacemaker implantation. At a mean follow up of 15.5 ± 15 months; all patients had improvement in New York Heart Association functional class. Follow up echocardiography revealed improved or stable left ventricular ejection fraction and optimal device function in all cases.ConclusionsTAVI with the CRS bioprosthesis is feasible and effective in appropriately selected cases of severe aortic regurgitation in native and bioprosthetic aortic valves.© 2012 Wiley Periodicals, Inc.
Industrial Biotechnology – The Unique Tool for Big Industry to Handle Climate Change
Authors: Ringpfeil Manfred 
Published: September 2012

AbstractThe connection between production of energy and climate change is elucidated. CO2 from burning fossil carbon is the main agent responsible for the hazardous climatic development. The use of this process in energy production has to be vigorously restricted. The gaps have to be filled by conversion of renewable carbon into reduced forms. Big industry shall adopt biotechnology as an enabling technology.
Sediments Quality Assessment of Jacarepaguá Lagoon: The Venue of the 2011 Rock in Rio
Authors: Araruna Júnior José Tavares , Benedetti Paula Elias , Pires Patrício José Moreira , de Almeida Ricardo Froitzheim Rinelli 
Published: September 2012

AbstractIn order to aid in the efforts of the 2016 Olympic Games, the organizers of 2011 Rock in Rio decided to build a permanent venue next to the Olympic Park. The area is problematic from the geotechnical point of view since it presents soils with low shear strength, low permeability, and high plasticity, so major soil improvement works were carried out. Bored soil–cement columns were placed to increase soil shear strength and reduce compressibility. A meter thick fill composed of gneiss residual soil was placed and trenches were digged to drain rainwater. However, earlier studies conducted on Jacarepaguá Lagoon have detected the presence of heavy metals in these sediments. In this study, an environmental survey on the Jacarepaguá Lagoon sediments took place in order to choose a place where its sediments could be dredged to be later used in the drainage facilities. The results indicated areas where the threshold level 1 (low probability of adverse effects) issued by the general procedures for sediments quality assessments for dredging purposes, Resolution no 344 of the Brazilian Federal Government, was surpassed. Levels above the limits established for cadmium (Cd), lead (Pb), copper (Cu), nickel (Ni), and zinc (Zn) were detected. Based on this consideration the State Environmental Agency issued a permit allowing the organizers of 2011 Rock in Rio to dredge an area close to City of Rock in order to obtain coarse sediments for the drainage facilities. In addition, it was found that those sediments were ideal for this application since their hydraulic conductivity is on the order of 10−2 cm/s.
Hydro‐morphologic Revision of the Cuautla Channel at Nayarit, Mexico
Authors: Ochoa Cuauhtemoc Franco , Baldwin Edgar Mendoza , Casarín Rodolfo Silva , Martínez Gabriel Ruiz 
Published: September 2012

AbstractPollution, habitat modification, and species migration are some of the results of human activities on natural environments which can be mitigated or compensated with proper planning. Irresponsibility or ignorance in planning coastal projects too often produces damage to natural systems which can be unpredictable and sometimes irrevocable. The specific site analyzed in this paper is the Cuautla littoral sub‐system which was originally a lagoon that diverted river water to other lagoons and estuaries, thus irrigating the Mexican Marismas Nacionales system, in the states of Nayarit and Sinaloa, Mexico. In the 1970s social and economic considerations motivated the construction of a small breaching canal from the sea to the lagoon. The subsequent growth of this channel was unforeseen and has produced an irreversible impact not only in the sub‐system but probably in the entire area of Marismas Nacionales. A lack of understanding of the present balances in the damaged system and of the impacts the changing morphology has on future change has created the need to study this area using numerical hydrodynamic simulation. The present distribution of water in the sub‐system was established and the governing processes were detected. By means of an analytical estimation of equilibrium conditions it was found that if nothing is done, the channel will continue eroding and the ecosystem will continue to degrade. Only by understanding the dramatic perturbations caused by the construction of the channel to the hydrologic and morphologic equilibriums can there be any hope of rescuing the ecosystem, including its human activities.
Effects of Anesthetics, Sedatives, and Opioids on Ventilatory Control
Authors: Stuth Eckehard A.E. , Stucke Astrid G. , Zuperku Edward J. 
Published: September 2012

AbstractThis article provides a comprehensive, up to date summary of the effects of volatile, gaseous, and intravenous anesthetics and opioid agonists on ventilatory control. Emphasis is placed on data from human studies. Further mechanistic insights are provided byin vivoandin vitrodata from other mammalian species. The focus is on the effects of clinically relevant agonist concentrations and studies using pharmacological, that is, supraclinical agonist concentrations are de‐emphasized or excluded. © 2012 American Physiological Society.Compr Physiol2:2281‐2367, 2012.
Solubility and metastable zone width of DL‐tartaric acid in aqueous solution
Authors: Zhang Xiang‐Yang , Wang Xiaofang , Hao Lin , Yang Xiaowu , Dang Leping , Wei Hongyuan 
Published: September 2012

AbstractSolubility and metastable zone width (MSZW) of DL‐tartaric acid (DL‐TA) in aqueous solution have been determined. Solubility of DL‐TA was measured in the temperature range from 0 to 50 °C at atmospheric pressure by means of the conventional polythermal method using Turbidity Monitoring Technique, which was verified by a gravimetric method. The dissolution enthalpy and entropy of DL‐TA were then calculated from the solubility data using van't Hoff equation. Two approaches was used to estimate the nucleation kinetics from the measured metastable zone width data, the self‐consistent approach and the approach based on 3D nucleation. In addition, the metastable zone width slightly decreases with increasing agitation rate and was independent of working volume.
Redox Activity in a Vanadium(V)–o‐Dioxolene Complex Is Modulated by Protonation State As Indicated by 51V Solid‐State NMR Spectroscopy and Density Functional Theory
Authors: Chatterjee Pabitra B. , Goncharov‐Zapata Olga , Hou Guangjin , Dmitrenko Olga , Polenova Tatyana , Crans Debbie C. 
Published: September 2012

AbstractMost known vanadium(V) complexes with redox‐active o‐dioxolene ligands are non‐innocent. Since the vanadium(V) complex [VO(gsal)(HCat)] is innocent, its properties were investigated by 51V solid‐state NMR spectroscopy and density functional theory (DFT). The innocent ligand behavior manifested itself by the upfield isotropic chemical shift and large negative chemical shift anisotropy observed in the solid state. The electronic structure and NMR spectroscopic parameters of this complex were addressed by DFT calculations and found to be consistent with the NMR spectroscopic observations indicating that the complex is redox‐inactive. The observed increase in the HOMO–LUMO gap for the innocent complex is concomitant with the 51V NMR chemical shift of –460 ppm and consistent with the high redox stability of this molecule. The stabilization was traced to the overall charge of [VO(gsal)(HCat)] facilitated by the coordination of the minus‐one‐charged o‐dioxolene ligand and rendering the overall complex neutral. These studies suggest that protonation may prove to be an effective way in which vanadium(V) complexes with redox‐active ligands can be stabilized.