bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Analysis of the Effectiveness of Information and Communication Technology Technologies in Providing Customer Feedback to Enhance B2C Value Co-creation: A Focus on the Tourism Industry
Authors: Mgoduka Siyasanga , Kaseeram I. , Heeralal S. 
Published: July 2024

Recent tourism research has shown a move towards the perspective on ‘value-in-use’ or ‘value-in-context’ that customers can co-create value through interactions with tourism organizations. As value is co-created through an ongoing interactive learning process, customers are involved in every step of service creation, from jointly defining problems to collaboratively solving them, this is enabled through intense engagement and dialogue possibilities between customers and companies. This study aims to analyse the effectiveness of ICT technologies in providing customer feedback to enhance B2C value co-creation. Information and communication technology (ICT) competences have been deemed essential for the use and execution of digital solutions, including external relationship management, technical proficiency, and planning. The results from this current study indicated a strong positive relationship between customer feedback in a form of transparency and value co-creation. Moreover, this study found that ICT platforms such as social media and emails are the fastest way to exchange digital messages over the internet and are thought to be the most recent, dependable method in marketing and electronic commerce. Furthermore, this study revealed a strong positive relationship between customer feedback in a form of a dialogue and its contribution to value co-creation. Therefore, this study concludes that firms should engage consumers in a dialogue regarding the service provision through the use of ICT technologies in order to enhance value co-creation.
The role of Nrf2 transcription factors in various physiological and pathological states
Authors: Yastani Deasyka , Jusman Sri Widia A 
Published: July 2024

Since its first report in 1994, understanding of the nuclear factor erythroid 2-related factor 2 (Nrf2) has continued to grow. Initially recognized for its role in cellular response to oxidative stress, Nrf2 is now known to be involved in a variety of regulatory process, including metabolic regulation, autophagy, protein homeostasis (proteostasis), and mitochondrial biogenesis. The expression of Nrf2 target genes is highly dependent on stimulus activation and interactions with transcription factors, activators, and repressors. Nrf2 activation serves as a defense mechanism under physiological conditions, but in the context of cancer, it can trigger the development of cancer cells due to its complex roles. Nrf2 is strongly associated with the onset and development of many diseases, including those caused by metabolic disorders and inflammation. Understanding Nrf2's diverse functions offers valuable insights into disease pathogenesis and potential therapeutic approaches. This review explores the pleiotropic role of Nrf2 regulation.
التحديات التي أثرت على العملية التعليمية في اليمن نتيجة الصراعات
Authors: Al-Tahitah Ali Nasser 
Published: July 2024

ملخص
لا زال العالم يعاني من تفشي جائحة كورونا التي أثرت على كل مناحي الحياة على المستوى الفردي والجماعي والدولي على حد سوى في مختلف القطاعات والأعمال. كانت العملية التعليمية بكل مستوياتها الأساسي والثانوي والجامعي والدراسات العليا في كل البلدان أكثر القطاعات تضرراً حيث لا زالت معظم دول العالم تعاني من كيفية تأقلم الطلاب والمعلمين على تبني التعليم الافتراضي بديلاً للعملية التقليدية. وبما أن اليمن لا زالت تعاني من اضطرابات امنيه وسياسية واقتصادية جمة، اضحى الطلاب في الجامعات والمدارس اليمنية في عموم الجمهورية أكثر الشرائح تضرراً ليس خوفاً من الاصابة بهذا الفيروس فحسب، بل لضعف واحياناً لعدم وجود انترنت في معظم المناطق. تأتي هذه الدراسة للتعرف على أهم التحديات التي تواجه الطالب اليمني والتعرف على اهم الاثار التي قد يسببها هذا الوضع الاستثنائي الصعب. ستتبع الدراسة المنهج الاستقرائي من خلال تتبع وسرد الاثار والصعوبات التي تواجه الطلاب والمعلمين والأكاديميين في اليمن. وأتت لتسليط الضوء على اهم التحديات وتقديم بعض الاقتراحات والحلول لمعالجة هذه المشكلة التي قد تساعد من بأيدهم القرار في اخذ التدابير والحلول لمثل هذه التحديات.
The world is still suffering from the COVID-19 outbreak, which has affected all aspects of life at the individual, collective and international levels. The educational sectors at all levels of elementary and high school, as well as at university levels in all countries was the most affected. Most countries of the world are still suffering from how students and teachers adapt virtual education as an alternative to the traditional process. Since Yemen is still suffering from a lot of security, political and economic turmoil, students in Yemeni universities and schools have become the most affected, not just out of fear of the virus, but also of the weakness of internet connection in most areas. This study comes to identify the most important challenges facing Yemeni students and identify the most important effects that this exceptional and difficult situation may cause. The study will follow the inductive approach by tracking and narrating the effects and difficulties facing students, teachers, and academics in Yemen. It came to shed light on the most important challenges and present some suggestions and solutions to address this problem, which may help those in decision-making power to take action and solutions to such challenges.
Celebrity Endorsement and the Buying Behavior in Consumers of Nepal
Authors: Upadhyay Jitendra Prasad , Singh Sanju Kumar 
Published: July 2024

The main objective of the study is to analyze the influence of celebrity endorsement on consumers’ buying behavior. Celebrity endorsement is considered the most effective tool to influence the customers’ buying behavior and motivate them to get attention towards the products produced by the company and services provided by the company. Due to the specific nature of research objectives, descriptive and causal comparative research design has been used. Celebrity endorsement has higher impact on Consumer Buying Behavior of Nepal. In this research descriptive and causal comparative research design has been used. The study focuses on understanding the consumers buying behavior based on different factors like gender, income, occupation and education. Population of this research is total youth of Nepal and out of total population a sample size of 384 respondents is taken using the convenience sampling technique which consists of people from different age group, gender, income, occupation. The results of this study indicated that there was a positive impact of celebrity trustworthiness, features of products and attractiveness on consumer buying behavior. Moreover, results showed that most of the consumers agreed that celebrity endorsers enhanced brand awareness.
Solution chemistry and anti-proliferative activity against glioblastoma cells of a vanadium(V) complex with two bioactive ligands
Authors: Levina Aviva , Scalese Gonzalo , Gambino Dinorah , Crans Debbie C. , Lay Peter A. 
Published: July 2024

Introduction: Glioblastoma is a brain cancer difficult to treat but recently mixed-ligand vanadium(V) Schiff base/catecholato complexes have exhibited high in vitro anti-proliferative activity. Hence, we explored the activity of [VVOL1L2], which contains two iron chelating ligands, 2-hydroxy-1-naphthylaldehyde iso-nicotinoyhydrazone (L1H2) and clioquinol (L2H). This complex was previously reported to be very effective against Trypanosoma cruzi, the causative agent of Chagas disease. These studies explored the possibility that a compound with efficacy against Trypanosoma cruzi also has efficacy against human glioblastoma cancer cells. Since [VVOL1L2] was poorly soluble in water and the clioquinol ligand dissociated from the complex upon addition to an aqueous environment, an understanding of the speciation was very important to interpret its biological activity.Methods: Stability studies in cell media were followed by UV/Vis spectroscopy to determine speciation of relevance to the in vitro anti-proliferative activity of the complex with T98G glioblastoma cells, which was also measured in the absence and presence of Fe(III).Results and Discussion: The current work demonstrated that the mixed-ligand vanadium coordination complex had high in vitro anti-proliferative activity against the human glioblastoma (T98G) cell line. The enhanced anti-proliferative effects of the mixed-ligand vanadium complex against T98G cells could be due to either hydrolysis of complex and release of the toxic clioquinol, or the rapid uptake of the lipophilic complex prior to hydrolysis. The speciation studies showed that at least part of the potent toxicity of the mixed-ligand coordination complex stemmed from release of the bioactive clioquinol ligand from the complex, which depended on whether Fe(III) was present. The studies also showed that the [VV(O)2 (L1H)] coordination complex was the most potent complex that remained intact and, hence, the complex that is the most biological active. Thus, future development of complexes should focus on the one-ligand intact complexes or making any mixed-ligand complex more water soluble, stable in aqueous solution, or designed to be rapidly taken up by diseased cells prior to hydrolysis.
Multifunctional and bioinspired titanium surface with multilayer nanofilms for novel dental implant applications
Authors: Wang Caiyun , Lu Ran , Cao Xu , Mu Yanting , Chen Su 
Published: July 2024

Introduction: Smart multifunctional surfaces targeting intricate biological events or versatile therapeutic strategies are imminent to achieve long-term transmucosal implant success.Methods: This study used dopamine (DA), graphene oxide (GO), and type IV collagen (COL-IV) to construct multilayer nanofilms (DGCn) based on their universal adhesive and biomimetic properties to design a versatile and bioactive titanium implant. The characterization of DGCn on different titanium surfaces was performed, and its loading capacity, release profile, in situ gene delivery, and in vitro biological properties were preliminarily evaluated.Results: Our results demonstrate that hydrogenated TiO2 nanotubes (H) provide a better platform for the DGCn coating than machined Ti and air-TiO2 nanotubes. The H-DGC10 displayed the most stable surface with excellent loading capacity, sustained-release profile, and in situ gene transfection efficiency; this could be due to the high specific surface area of H and GO, as well as the functional groups in H, DA, and GO. Moreover, the H-DGC10 exhibited good biocompatibility for human oral epithelial cells and promoted the expression of integrin β4 and laminin 332, both being hemidesmosome-related proteins.Discussion: Our findings suggest that H-DGCn can be designed as a smart multifunctional interface for titanium implants to achieve long-term transmucosal implant success and aid in versatile therapeutic strategies.
A user-friendly machine learning approach for cardiac structures assessment
Authors: Orhan Atilla , Akbayrak Hakan , Çiçek Ömer Faruk , Harmankaya İsmail , Vatansev Hüsamettin 
Published: July 2024

BackgroundMachine learning is increasingly being used to diagnose and treat various diseases, including cardiovascular diseases. Automatic image analysis can expedite tissue analysis and save time. However, using machine learning is limited among researchers due to the requirement of technical expertise. By offering extensible features through plugins and scripts, machine-learning platforms make these techniques more accessible to researchers with limited programming knowledge. The misuse of anabolic-androgenic steroids is prevalent, particularly among athletes and bodybuilders, and there is strong evidence of their detrimental effects on ventricular myocardial capillaries and muscle cells. However, most studies rely on qualitative data, which can lead to bias and limited reliability. We present a user-friendly approach using machine learning algorithms to measure the effects of exercise and anabolic-androgenic steroids on cardiac ventricular capillaries and myocytes in an experimental animal model.MethodMale Wistar rats were divided into four groups (n = 28): control, exercise-only, anabolic-androgenic steroid-alone, and exercise with anabolic-androgenic steroid. Histopathological analysis of heart tissue was conducted, with images processed and analyzed using the Trainable Weka Segmentation plugin in Fiji software. Machine learning classifiers were trained to segment capillary and myocyte nuclei structures, enabling quantitative morphological measurements.ResultsExercise significantly increased capillary density compared to other groups. However, in the exercise + anabolic-androgenic steroid group, steroid use counteracted this effect. Anabolic-androgenic steroid alone did not significantly impact capillary density compared to the control group. Additionally, the exercise group had a significantly shorter intercapillary distance than all other groups. Again, using steroids in the exercise + anabolic-androgenic steroid group diminished this positive effect.ConclusionDespite limited programming skills, researchers can use artificial intelligence techniques to investigate the adverse effects of anabolic steroids on the heart's vascular network and muscle cells. By employing accessible tools like machine learning algorithms and image processing software, histopathological images of capillary and myocyte structures in heart tissues can be analyzed.
Pancreatic cancer mortality trends attributable to high fasting blood sugar over the period 1990–2019 and projections up to 2040
Authors: Wei Yongguang , Qin Zedong , Liao Xiwen , Zhou Xin , Huang Huasheng , Lan Chenlu , Qin Wei , Zhu Guangzhi , Su Hao , Peng Tao 
Published: July 2024

BackgroundPancreatic cancer (PC) is a prevalent malignancy within the digestive system, with diabetes recognized as one of its well-established risk factors.MethodsData on PC mortality attributed to high fasting blood sugar were retrieved from the Global Burden of Disease (GBD) study 2019 online database. To assess the temporal trends of PC burden attributable to high fasting plasma glucose (HFPG), estimated annual percentage changes (EAPCs) for age-standardized death rates (ASDRs) between 1990 and 2019 were determined using a generalized linear model. Furthermore, a Bayesian age-period-cohort (BAPC) model using the integrated nested Laplacian approximation algorithm was employed to project the disease burden over the next 20 years.ResultsGlobally, the crude death number of PC attributable to HFPG almost tripled (from 13,065.7 in 1990 to 48,358.5 in 2019) from 1990 to 2019, and the ASDR increased from 0.36/100,000 to 0.61/100,000 with an EAPC of 2.04 (95% CI 1.91–2.16). The population aged ≥70 years accounted for nearly 60% of total deaths in 2019 and experienced a more significant increase, with the death number increasing approximately fourfold and the ASDR increasing annually by 2.65%. In regions with different sociodemographic indexes (SDIs), the highest disease burden was observed in the high-SDI region, whereas more pronounced increasing trends in ASDR were observed in the low to middle-SDI, low-SDI, and middle-SDI regions. Additionally, a significantly negative association was found between EAPCs and ASDRs of PC attributable to HFPG from 1990 to 2019. Moreover, the BAPC model predicts that ASDR and age-standardized disability-adjusted life-years (DALYs) rate for PC attributed to HFPG was projected to increase obviously for men and women from 2019 to 2040.ConclusionsThe burden of PC attributed to HFPG has increased globally over the past three decades, with the elderly population and high-SDI regions carrying a relatively greater disease burden, but more adverse trends observed in low-SDI areas. Furthermore, the burden is projected to continue increasing over the next 20 years. Hence, more tailored prevention methodologies should be established to mitigate this increasing trend.
New specific skeletal muscle mass index cut-offs for the assessment of sarcopenia in patients with severe obesity
Authors: Bufano Annalisa , Cartocci Alessandra , Benenati Nicoletta , Ciuoli Cristina , Simon Batzibal Maria , Bombardieri Alessio , Iraci Sareri Gabriele , Sannino Ida , Tirone Andrea , Voglino Costantino , Vuolo Giuseppe , Castagna Maria Grazia 
Published: July 2024

IntroductionBioelectrical impedance analysis (BIA) is the most used tool in clinical practice to evaluate body composition in patients with obesity. The skeletal muscle index (SMI) defined by BIA has been proposed for the identification of sarcopenia, but there are currently no univocal cutoffs for this condition. In this study, we aimed: 1) to determine the prevalence of sarcopenia in patients with severe obesity using the current cutoffs of SMI; 2) to define new specific cutoffs; 3) to validate the new cutoffs; and 4) to re-determine the prevalence of sarcopenia.MethodsA total of 300 patients, 74% women and 26% men (mean age = 42.6 ±; 9 years), with morbid obesity (mean BMI = 46.7 ±; 6.5 kg/m2) followed by the Unit of Endocrinology from January 2014 to December 2020 were retrospectively evaluated. SMI was calculated as the skeletal muscle mass normalized for squared height through the BIA equation by Janssen et al.ResultsThe prevalence of sarcopenic obesity calculated using the cutoff points reported by De Rosa et al. (7.3 kg/h2 for women and 9.5 kg/h2 for men) was 2.3%. The prevalence of sarcopenia was calculated using the new cutoffs: with the cutoff obtained from the standard deviation method (8.2 kg/h2 for women and 10.2 kg/h2 for men), a prevalence of 14.7% was observed, whereas the prevalence reached 47.6% when using the cutoff calculated through the K-means unsupervised cluster (9.2 kg/h2 for women and 11.3 kg/h2 for men). The new cutoffs were validated with a second sample consisting of 300 patients with morbid obesity (BMI = 44.9 ±; 6.7 kg/m2): the rate of sarcopenic patients was still higher than that observed in the training cohort (56%). After the matching procedure (by BMI and age), the rates of sarcopenic patients were similar in both groups (50.2% in the validation group and 53% in the training group, p = 0.6).ConclusionThe new cutoffs calculated with cluster analysis could better identify sarcopenia in morbidly obese patients. However, further studies are needed to validate these cutoffs in different patient cohorts.
Associations between total, free and bioavailable 25-hydroxyvitamin D forms with adiponectin and irisin in maternal-neonatal pairs at birth from Greece
Authors: Arabi Tarek Ziad , Fakhoury Hana M. A. , Tamim Hani , Chun Rene F. , Hewison Martin , AlAnouti Fatme , Pilz Stefan , Annweiler Cedric , Tzimagiorgis Georgios , Haitoglou Costas , Karras Spyridon N. 
Published: July 2024

BackgroundApart from the well-established skeletal effects, vitamin D has been explored as a secretagogue influencing various adipokines, including adiponectin and irisin. Recent evidence suggests that specific forms of 25-Hydroxyvitamin D (25(OHD), such as free and bioavailable 25(OH)D, may provide more accurate measurements of vitamin D status. The relationship between vitamin D status and serum irisin and adiponectin concentrations remains largely unexplored, particularly during pregnancy.MethodsWe analyzed data from 67 healthy maternal-neonatal pairs from Northern Greece at birth. Biochemical and hormonal tests were conducted on each maternal-neonatal pair. The vitamin D forms were estimated using validated mathematical models. Subsequently, regression analyses were conducted to determine the association between the vitamin D forms and adipokine levels.ResultsBioavailable maternal 25(OH)D was inversely associated with neonatal irisin concentrations [β=-73.46 (-140.573 to -6.341), p=0.034]. No other associations were observed between maternal vitamin D status and neonatal adipokine concentrations.ConclusionIn conclusion, maternal bioavailable vitamin D concentrations are inversely associated with neonatal serum irisin concentrations, warranting further studies to evaluate the underlying mechanisms for this finding.
Case report: An adolescent female with anosmic hypogonadotropic hypogonadism, intellectual disability, and papillary thyroid carcinoma: heterozygous deletion of TCF12
Authors: Celik Nur Berna , Sezer Abdullah , Genel Nebiyye , Savas-Erdeve Senay , Karaman İbrahim , Cetinkaya Semra 
Published: July 2024

BackgroundIsolated hypogonadotropic hypogonadism is a heterogeneous clinical entity. There is a growing list of molecular defects that are associated with hypogonadotropic hypogonadism (HH). TCF12, a recently identified molecular defect, causes craniosynostosis and is suggested to be used as a biomarker for prognosis in various cancer types. Recently, TCF12 variants were shown in a cohort with HH.Case presentationA 15.3 years old female patient was referred to the endocrinology clinic for obesity. She had been gaining weight from mid-childhood. She had her first epileptic seizure at the age of 15.1 years and mildly elevated thyroid autoantibodies were detected during evaluation for etiology of seizures. She had not experienced menarche yet. She was operated for left strabismus at the age of 7 years. School performance was poor and she was receiving special education. Tanner stage of breast was 1 and pubic hair was 3. The endocrine workup revealed hypogonadotropic hypogonadism. Also, the Sniffin’ Sticks test detected anosmia. Thyroid ultrasonography was performed due to the mildly elevated thyroid autoantibodies, and thyroid nodules with punctate calcifications were detected. Total thyroidectomy and central lymph node dissection were performed regarding the cytological findings of the nodules and multicentric papillary thyroid carcinoma with no lymph node metastasis was detected on pathology specimens. Regarding the phenotypic features of the patients, whole exome sequencing was performed and heterozygous deletion of exon 1 and exon 6–8 in TCF12 was detected.ConclusionHaploinsufficiency of TCF12 causes anosmic HH. Probably due to the incomplete penetrance and variable expressivity of the disease, patients could display variable phenotypic features such as intellectual disability, developmental delay, and craniosynostosis. Further description of new cases with TCF12 variations could enhance our understanding of craniosynostosis and its potential link to Kallmann syndrome associated with this gene.