bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonsuicidal self-injury as the gateway and consequence of suicidal ideation among adolescents: a cross-lagged regression analysis
Authors: Xu Zhansheng , Li Nianqin , Kong Yaxin , Lin Lin , Liu Yu , Zhang Huan , He Yunfeng , Zhao Song 
Published: August 2024

BackgroundThere is a consensus that both nonsuicidal self-injury (NSSI) and suicidal ideation as risk factors for suicidal behavior have a strong connection. However, a lack of longitudinal information has limited the clarification of the concrete relationship between them.AimsThis study aimed to examine the specific mechanism between NSSI and suicidal ideation over time, during adolescence.MethodA longitudinal study was conducted with 193 Chinese adolescents. NSSI and suicidal ideations were examined over the course of a 1year followed-up, and three waves of data were collected.ResultsThe NSSI at time T1 significantly positively predicted suicidal ideation at time T2; Suicidal ideation at time T2 also significantly positively predicted NSSI at time T3.LimitationsGiven that the small number of participants with suicidal ideation and NSSI, the findings of the study should be interpreted with caution and a lager sample is needed in the future.ConclusionIt was suggested that NSSI may occur before suicidal ideation, which in turn would strengthen NSSI, so interventions should be carried out from two aspects (behaviors and thoughts) to improve adolescents’ mental health.
Empirical analysis of health-related behaviors among older Hakka adults: a latent class analysis
Authors: Cai Longhua , Zhang Lingling , Liu Xiaojun 
Published: August 2024

BackgroundLittle is known about health-related behaviors of the older Hakka population in China. We aimed to explore the characteristics and correlates of health-related behaviors among older Hakka adults.MethodsWe used data from the China’s Health-Related Quality of Life Survey for Older Adults 2018. Latent class analysis (LCA) defined latent classes of health-related behaviors for 1,262 older Hakka adults aged 60 and above. Generalized linear regression and multinomial logistic regression analysis were used to identify factors influencing the number and the latent classes of health-related behaviors, respectively.ResultsThe LCA showed that the latent classes could be stratified as the risk group (14.82%), healthy group (55.71%), and inactive group (29.48%). Sex, age, years of education, current residence, living arrangement, average annual household income, and currently employed were associated with the number of healthy behaviors. Compared with the participants in the healthy group, widowed/others (OR = 5.85, 95% CI = 3.27, 10.48), had 15,001–30,000 (OR = 2.05, 95% CI = 1.21, 3.47) and 60,001 or higher (OR = 3.78, 95% CI = 1.26, 11.36) average annual household income, and currently employed (OR = 3.40, 95% CI = 1.99, 5.81) were highly associated with risk group. Additionally, the participants who are widowed/others (OR = 4.30, 95% CI = 2.70, 6.85) and currently employed (OR = 1.95, 95% CI = 1.27, 2.98) were highly associated with the inactive group.ConclusionThis study identified factors specifically associated with older Hakka adults’ health-related behaviors from an LCA perspective. The findings indicate that policymakers should give more attention to older adults living alone and implement practical interventions to promote health-related behaviors among them.
Comparative SARS-CoV-2 Omicron BA.5 variant and D614G-Wuhan strain infections in ferrets: insights into attenuation and disease progression during subclinical to mild COVID-19
Authors: Barroso-Arévalo Sandra , Sánchez-Morales Lidia , Porras Néstor , Díaz-Frutos Marta , Barasona Jose A. , Isla Julio , López Débora , Gortázar Christian , Domínguez Lucas , Sánchez-Vizcaíno Jose M. 
Published: August 2024

IntroductionAs the SARS-CoV-2 virus continues to evolve and new variants emerge, it becomes crucial to understand the comparative pathological and immunological responses elicited by different strains. This study focuses on the original Wuhan strain and the Omicron variant, which have demonstrated significant differences in clinical outcomes and immune responses.MethodsWe employed ferrets as an experimental model to assess the D614G variant (a derivative of the Wuhan strain) and the Omicron BA.5 variant. Each variant was inoculated into separate groups of ferrets to compare disease severity, viral dissemination, and immune responses.ResultsThe D614G variant induced more severe disease and greater viral spread than the Omicron variant. Notably, ferrets infected with the D614G variant exhibited a robust neutralizing antibody response, whereas those infected with the Omicron variant failed to produce a detectable neutralizing antibody response. Despite the clearance of the virus from nearly all tissues by 7 days post-infection, an increase in pathological lesions was observed from 14 to 21 days, particularly in those infected with the D614G variant, suggesting a sustained immune response even after viral clearance.DiscussionThese findings underscore the adaptability of SARS-CoV-2 and illuminate how susceptibility and clinical manifestations vary across different strains and species. The results emphasize the necessity of considering both the direct effects of viral infection and the indirect, often prolonged, impacts of the immune response in evaluating the outcomes of SARS-CoV-2 infections.
Antibiotics Trigger Host Innate Immune Response via Microbiota–Brain Communication in C. elegans
Authors: Wu Yangyang , Li Guanqun , Tang Hongyun 
Published: August 2024

Besides their direct bactericidal effect, antibiotics have also been suggested to stimulate the host immune response to defend against pathogens. However, it remains unclear whether any antibiotics may stimulate the host immune response by affecting bacterial activity. In this study, reasoning that genetic mutations inhibit bacterial activities and, thereby, may mimic the effects of antibiotics, we performed genome-wide screening and identified 77 E. coli genes whose inactivation induces C. elegans cyp-14A4, representing an innate immune and detoxification response. Further analyses reveal that this host immune response can clearly be induced through either inactivating the E. coli respiratory chain via the bacterial cyoB mutation or using the antibiotic Q203, which is able to enhance host survival when encountering the pathogen Pseudomonas aeruginosa. Mechanistically, the innate immune response triggered by both the cyoB mutation and Q203 is found to depend on the host brain response, as evidenced by their reliance on the host neural gene unc-13, which is required for neurotransmitter release in head neurons. Therefore, our findings elucidate the critical involvement of the microbiota–brain axis in modulating the host immune response, providing mechanistic insights into the role of antibiotics in triggering the host immune response and, thus, facilitating host defense against pathogens.
Novel Treatments in Refractory Recurrent Pericarditis
Authors: Lazarou Emilia , Koutsianas Christos , Vlachakis Panayotis K. , Theofilis Panagiotis , Vassilopoulos Dimitrios , Tsioufis Costas , Lazaros George , Tousoulis Dimitris 
Published: August 2024

Refractory recurrent pericarditis is a troublesome condition that severely impairs the quality of life of affected patients and significantly increases healthcare spending. Until recently, therapeutic options included only a few medications and most of the patients resorted to chronic glucocorticoid treatment with steroid dependence. In the most recent decade, the introduction of interleukin-1 blockers in clinical practice has revolutionized the treatment of glucocorticoid-dependent and colchicine-resistant recurrent pericarditis due to their excellent efficacy and good safety profile. The rationale for the introduction of this class of medications in clinical practice is the autoinflammatory nature of recurrent pericarditis in a substantial rate of cases, with interleukin-1 being the main pro-inflammatory cytokine involved in this context. This review aims to discuss the contemporary available evidence from original research and real-world data on interleukin-1 blocker use in refractory recurrent pericarditis, in terms of indications, mechanism of action, efficacy, side effects, and recommended treatment protocols. Moreover, novel treatment proposals, such as hydroxychloroquine, beta blockers, and cannabidiol, which showed encouraging preliminary results, are addressed. Finally, gaps in knowledge, unmet needs, and future perspectives related to recurrent pericarditis are thoroughly discussed.
The Development of Natural and Cultural Tourism in Buku Limau Island Based on Social Networking
Authors: Saputra Putra Pratama , Bahtera Novyandra Ilham , Hayati Laila 
Published: August 2024

The local authorities are promoting Buku Limau Island as an emerging tourist site. The island's distinguishing features include stunning coral reefs, picturesque white sandy beaches, and its role as a hub for the production of salted and fresh seafood. The objective of this study is to identify and describe the natural and cultural attractions on Buku Limau Island, particularly in the Manggar Subdistrict of East Belitung Regency. Additionally, the study seeks to examine social networks in order to facilitate the development and expansion of natural and cultural tourism destinations in the area. This research employs a mixed-method approach, utilizing data gathering approaches such as observation, focus group discussions (FGD), and surveys administered through questionnaires. UCINET program was used to conduct descriptive qualitative analysis and social network analysis to identify and reveal tourist characteristics. This is followed by the breakdown and study of social networks among stakeholders and interest groups. The findings of this study indicate that Buku Limau Island exhibits attributes of both natural and cultural tourism, with the predominant population of fishermen being of Bugis ethnicity. The identification and study of social networks demonstrate that stakeholders have formed networks to actively support and cultivate tourism attractions, encompassing both natural and cultural aspects. Nevertheless, there are still certain stakeholders who have not been engaged in the network throughout the process of developing and improving the tourism destination. The research limits are deliberately established to enhance the study's focus and depth. The information and data acquired are directly relevant to the fundamental issue of this investigation. The scope of this study is limited to the creation of natural and cultural tourism centered around social networks on Buku Limau Island. Theoretical implications shed light on the ideas of local government assistance, social networks, and tourist attractions. Meanwhile, the practical consequences surely affect the government, tourism stakeholders, and the community in their efforts to promote the growth of natural and cultural tourism through social networks on Buku Limau Island.
Diabetes insipidus central secundária a histiocitose maligna: um relato de caso
Authors: Prado Eduardo Henrique Meneses , Gonçalves Ana Luiza Faria , Tarabal Dafne Gonçalves Nogueira , Rezende Neto Geraldo Morais 
Published: August 2024

Introdução: A histiocitose de células de Langerhans (HCL) é um distúrbio raro do sistema fagocitário mononuclear, caracterizado pela proliferação excessiva de células dendríticas. Uma das manifestações frequentes é o diabetes insipidus central (DIC), resultante da destruição dos neurônios hipotalâmicos produtores de arginina vasopressina (AVP), que se manifesta com poliúria. Relato de caso: paciente feminina, 58 anos com diabetes mellitus tipo 2 e histórico de histiocitose maligna, admitida com quadro de hiperglicemia grave e poliúria intensa. Após tratamento inicial para controlar os níveis glicêmicos e hidratação, persistiu desorientada e hipernatrêmica, sendo diagnosticada com DIC. Exames anteriores revelaram ressecção parcial da histiocitose e tratamento quimioterápico, destacando a correlação entre DIC e histiocitose. Discussão: o diagnóstico de DIC secundária à histiocitose envolve anamnese detalhada, exame físico e exames complementares. O manejo inclui terapia com desmopressina para controlar os sintomas, uma vez que a reversão completa do DIC é rara. A complexidade diagnóstica e as potenciais complicações graves sublinham a importância de considerar a histiocitose como um diagnóstico diferencial em pacientes com DIC, facilitando intervenções precoces e adequadas. Conclusão: o DIC é uma doença rara e de difícil diagnóstico. Esse relato demonstra a importância de uma história clínica bem detalhada e reforça a importância da análise dos diagnósticos diferenciais possíveis.
Clampeamento tardio de cordão umbilical em gestantes com diagnóstico de HIV
Authors: Bezerra Matheus Guilherme , Almeida Walerya Gonçalves de , Moreira Caio Oliveira , Almeida Yanca Rodrigues de , Machado Junior Benjamim Arnaldo Morais Nunes , Silva Carolina Muniz e , Reis Aline Silva , Santana Natália Oliveira , Han Izabella Kimel Pessato , Han Lucas Yunzhi Pessato , Liz Kleifer Francisco de , Brito Bruna Rojo 
Published: August 2024

É apontado ainda que ao depender da forma como a notícia do diagnóstico foi passada o impacto se tornou maior, muitas relataram choque, acompanhado de medo e pânico, tristeza e desesperança, tendo em vista, que a maioria delas associaram o HIV a uma sentença de morte e logo passaram a apresentarem uma preocupação constante de contaminar as pessoas que amavam e afetar nesse processo também a criança e o risco de transmissão. O corte do cordão umbilical em gestantes com HIV deve ser realizado com cuidado para minimizar o risco de transmissão vertical do vírus para o bebê. Uso de Terapia Antirretroviral - TARV. Administração de AZT; .Essas medidas são Se você tiver mais dúvidas ou precisar de informações específicas, é sempre bom consultar um profissional de saúde especializado.
Germinação e vigor na cultura do milho sob tratamento com bioestimulante para sementes
Authors: Costa Marianne Paula Santos da , Sousa Marília Caixeta , Brandão Fernando João Bispo , Ormond Antonio Tassio Santana , Silva Magnun Antonio Penariol da , Matos Victor Arlindo Taveira de 
Published: August 2024

Os tratamentos de sementes promovem um melhor desenvolvimento das plantas, visando maior vigor e produtividade, além de favorecer uma melhor expressão genética e hormonal. Esta pesquisa teve como objetivo analisar o efeito de diferentes doses de um fertilizante organomineral no tratamento de sementes, com foco na melhoria do desenvolvimento inicial das plântulas. Os tratamentos foram acompanhados diariamente por sete dias, com o objetivo de verificar o índice de velocidade de germinação, porcentagem de germinação, porcentagem de plântulas normais e anormais, comprimento de parte aérea, comprimento radicular, massa fresca e seca das plântulas e o volume de raiz. Para isso foram feitos cinco (5) tratamentos, com diferentes doses do fertilizante organomineral Emerge®, cada um com quatro (4) repetições: T1- Testemunha (0,0 mL/kg de semente); T2 – 2,0 mL/kg de semente; T3- 4,0 mL/kg de semente; T4- 6,0 mL/kg de semente; T5- 8,0 mL/kg de semente. Cada repetição consistiu em 50 sementes, totalizando 200 sementes por tratamento. Os testes foram realizados em papel germiteste, em laboratório, sob condições controladas. Os resultados indicam que o uso do fertilizante não comprometeu a capacidade germinativa nem o vigor das sementes de milho. O tratamento T5 destacou-se por proporcionar um comprimento da parte aérea significativamente maior em comparação aos tratamentos T1 e T2. O tratamento T2, por sua vez, apresentou as maiores massas fresca e seca de raiz em relação à testemunha. Além disso, os tratamentos T2, T4 e T5 resultaram em volumes de raiz significativamente superiores à testemunha, com incrementos de até 40%.
Protection Of Embedded Systems For Applications Involving High Loading Rate Mechanical Forces
Authors:   ,   Cork Institute of Technology, Alsakarneh Amjad 
Published: August 2024

This thesis describes the development of a methodology to optimise the dimensions and mechanical properties of force-absorbing layers surrounding miniaturised embedded electronic modules subject to high mechanical compressive/impact forces and vibration. While much has been published on the mechanical protection of electronic systems in larger scale applications, where traditional mechanical shock absorbers and springs can be used to protect the electronics, little has been published on the mechanical protection of miniature electronic modules embedded in smart structures and materials where traditional methods of mechanical protection are not feasible. The generalised system concept used in this thesis is of module encapsulation in a multilayer of rubber-like materials to net as a mechanical buffer. This meant that it was necessary to model and optimise a multilayer combination of soft/hard rubber-like materials and its geometries subject to a set of external constraints. To drive the research a challenging test vehicle was chosen - a sliotar containing sensing electronics. This posed considerable challenges of small size and strict constraints on final weight and mechanical properties - a situation very typical of a smart object where it is necessary to maintain the object's original size, weight and mechanical properties. To optimise the electronic protection, it was necessary to understand the complete impact system, i.e. the sliotar-hurley impact), again this is typical of a smart object scenario where the time-dependent variables of the impact system are needed to understand the object's interactions. Analysing the sliotar-hurley impact however presented many challenges from mechanical point-of-view which lead to a number of novel contributions to the state of the art, including (I) highly nonlinear materials characterisation and modelling and at low and high strain-rate loading conditions for hurling materials, (2) analytical studies and modelling to describe the impact of the "structures" (sliotar and hurley) analytically and to extract the coefficient of restitution (CoR) of the sliotar as a function of impact speed, (3) transient finite element analyses of highly nonlinear structures and materials under different mechanical loads, and (4) experimental validation of the developed models. Based on these analyses and models, a multilayer rubber buffer structure was designed and optimised to surround and protect an electronic module embedded in a sliotar subject to high static and dynamic mechanical forces while meeting constraints on sliotar size, weight, and mechanical properties. The final result was a 73% and 84% reduction in dynamic and static mechanical forces, respectively, on the embedded electronics. This novel contribution has put in place a methodology for design of property-constrained smart objects with embedded electronics protected from high mechanical forces using multilayer rubber buffer materials.
КОРРЕЛЯЦИИ МЕЖДУ МОРФОМЕТРИЧЕСКИМИ ПОКАЗАТЕЛЯМИ АТРОФИИ ГОЛОВНОГО МОЗГА И КЛИНИЧЕСКОЙ СИМПТОМАТИКОЙ ПРИ РАССЕЯННОМ СКЛЕРОЗЕ
Authors: Şirəliyeva R.K. , Memiş A. , Mirzəyev A.H. , Əliyev R.R. 
Published: August 2024

Məqalədə dağınıq skleroz (DS) zamanı baş beyninin atrofiyası ilə klinik simptomlar arasında korrelyasion əlaqələri öyrənmək məqsədilə aparılmış tədqiqat işi haqqında məlumat verilmişdir. Müşahidə altında yaşı 18-dən 60-a qədər olan 88 DS-li xəstə (58 qadın, 30 kişi) olmuşdur, onlardan 56 nəfərdə residiv-remittent DS (RRDS), 32 nəfərdə ikincili proqressiv gedişli DS (İPDS) müəyyən edilmişdir. Bütün müayinə olunanlarda baş beyninin maqnit-rezonans tomoqrafiyası (Voksel morfometriyası ilə) aparılmışdır. Müəyyən edilmişdir ki, DS-li xəstələrdə ağ maddənin qabarıq dəyişikliklərinə baxmayaraq, əlillik dərəcəsi ocaqlı zədələnmənin həcmindən deyil, baş beyninin atrofiyasından asılıdır. RRDS və İPDS zamanı baş beynində boz və ağ maddənin atrofiyasının morfometrik göstəriciləri ilə əlillik dərəcəsi və koqnitiv pozulmalar arasında dürüst əlaqə mövcuddur.
В статье представлены результаты исследования, проведенного с целью изучения корреляции между морфометрическими показателями атрофии головного мозга и клинической симптоматикой рассеянного склероза (РС). Под наблюдением находилось 88 больных (58 женщин, 30-мужчин) с РС в возрасте от 18 до 60 лет. Из них у 56 выявлен рецидив-ремиттирующий (РРРС), у 32-вторично прогрессирующий (ВПРС) тип течения заболевания. У всех больных была проведена магнитно-резонансная томография с воксельной морфометрией. Установлено, что у больных с РС, несмотря на выраженные изменения белого вещества, степень инвалидизации зависит от выраженности атрофии головного мозга и не связана с объёмом очагового поражения. У больных РРРС и ВПРС были выявлены достоверные связи между морфометрическими показателями атрофии серого и белого вещества головного мозга и степенью инвалидизации и когнитивными нарушениями.
The article presents the results of a study conducted to explore the correlation between morphometric indicators оf brain atrophy and clinical symptoms in multiple sclerosis (MS). 88 patients (58 women, 30 men) with MS aged 18 to 60 years were under observation. 56 patients had relapse-remitting multiple sclerosis (RRMS), 32 patients had a secondary progressive multiple sclerosis (SPMS) type of disease course. All patients underwent magnetic resonance imaging with voxel morphometry. It was found that in patients with MS, despite pronounced changes in white matter, the degree of disability depends on the severity of brain atrophy and is not related to the volume of focal lesion. There are significant relationships between morphometric indicators of atrophy of the gray and white matter of the brain and the degree of disability and cognitive impairment in RRMS and SPMS.
УЛЬТРАЗВУКОВАЯ ОЦЕНКА СТРУКТУРНЫХ ИЗМЕНЕНИЙ СОННЫХ АРТЕРИЙ У БОЛЬНЫХ ИШЕМИЧЕСКИМ ИНСУЛЬТОМ
Authors: Далли М.А. , Посохов Н.Ф. , Абдуллаев Р.Я. , Дудник Т.А. , Костюковская А.Е. , Васько Л.Н. , Жукова Т.А. 
Published: August 2024

В статье представлены сведения о проведении ультразвукового исследования каротидных артерий у больных перенесших ишемический инсульт в возрасте до 60 лет. Определена частота встречаемости различных типов бляшек на стенках каротидных артерий. Атеросклеротические изменения стенок общей сонной артерии (ОСА) в виде локального или диффузного утолщения стенки отмечены у 62 (83,8%) больных, перенесших инсульт. Стеноз ОСА в пределах 31-50% отмечен у 23 (31,1%) пациентов, 51-70% у 19 (25,7%) пациентов, более 70% - у 8(10,5%), соответственно.
Мягкие бляшки выявлены у 7 (9,5%) пациентов, кальцификация стенки ОСА в 17 (23,0%) случаев в 15 из которых она вызвала стеноз просвета артерии в пределах 31-50%. Крупные бляшки, вызывающие стеноз просвета ОСА более 50%, зарегистрированы в 19 (25,7%) случаев. Изъязвленные бляшки были диагностированы у 8 (10,8%) пациентов с инсультом – достоверно чаще (p<0,05), чем в группе сравнения.