bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal first-trimester dietary intake and childhood blood pressure: the Generation R Study
Authors: van den Hil Leontine C. L. , Rob Taal H. , de Jonge Layla. L. , Heppe Denise H. M. , Steegers Eric A. P. , Hofman Albert , van der Heijden Albert J. , Jaddoe Vincent W. V. 
Published: March 2013

Suboptimal maternal dietary intake during pregnancy might lead to fetal cardiovascular adaptations and higher blood pressure in the offspring. The aim of the present study was to investigate the associations of maternal first-trimester dietary intake with blood pressure in children at the age of 6 years. We assessed first-trimester maternal daily dietary intake by a FFQ and measured folate, homocysteine and vitamin B12 concentrations in the blood, in a population-based prospective cohort study among 2863 mothers and children. Childhood systolic and diastolic blood pressure was measured using a validated automatic sphygmomanometer. First-trimester maternal daily intake of energy, fat, protein and carbohydrate was not associated with childhood blood pressure. Furthermore, maternal intake of micronutrients was not associated with childhood blood pressure. Also, higher maternal vitamin B12 concentrations were associated with a higher diastolic blood pressure (0·31 mmHg per standard deviation increase in vitamin B12 (95 % CI 0·06, 0·56)). After taking into account multiple testing, none of the associations was statistically significant. Maternal first-trimester folate and homocysteine concentrations were not associated with childhood blood pressure. The results from the present study suggest that maternal Fe intake and vitamin B12 concentrations during the first trimester of pregnancy might affect childhood blood pressure, although the effect estimates were small and were not significant after correction for multiple testing. Further studies are needed to replicate these findings, to elucidate the underlying mechanisms and to assess whether these differences in blood pressure persist in later life.
Effect of dietary laminarin and fucoidan on selected microbiota, intestinal morphology and immune status of the newly weaned pig
Authors: Walsh A. M. , Sweeney T. , O'Shea C. J. , Doyle D. N. , O'Doherty J. V. 
Published: March 2013

A 2 × 2 factorial experiment was conducted to investigate the interactions between laminarin (LAM; 0 and 300 parts per million (ppm)) and fucoidan (FUC; 0 and 240 ppm) levels on intestinal morphology, selected microbiota and inflammatory cytokine gene expression in the weaned pig. There was an interaction between LAM and FUC supplementation on the Enterobacteriaceae population (P< 0·05) and the abundance of attaching and effacingEscherichia coli(AEEC) strains (P< 0·05) in the colon. Pigs offered the FUC diet had a reduced Enterobacteriaceae population compared with pigs offered the basal diet. However, the effect of FUC on the Enterobacteriaceae population was not observed when combined with LAM. Pigs offered the LAM diet had reduced abundance of AEEC strains compared with pigs offered the basal diet. However, there was no effect of LAM on the abundance of AEEC strains when combined with FUC. There was an interaction between LAM and FUC supplementation on villous height (P< 0·01) and the villous height:crypt depth ratio (P< 0·01) in the duodenum. Pigs offered the LAM or FUC diet had an increased villous height and villous height:crypt depth ratio compared with pigs offered the basal diet. However, there was no effect of the LAM and FUC combination diet on intestinal morphology. Pigs offered the LAM-supplemented diets had a lowerIL-6(P< 0·05),IL-17A(P< 0·01) andIL-1β(P< 0·01) mRNA expression in the colon compared with pigs offered the diets without LAM. In conclusion, supplementation with either LAM or FUC alone modified intestinal morphology and selected intestinal microbiota, but these effects were lost when offered in combination.
Macrobenthic community structure in tropical estuaries: the effect of sieve mesh-size and sampling depth on estimated abundance, biomass and composition
Authors: Valença Ana Paula Maria Cavalcanti , Santos Paulo Jorge Parreira dos 
Published: March 2013

Macrobenthic data from estuaries along the Pernambuco coast in north-eastern Brazil were analysed to evaluate the effect of sieve mesh size (1.0 mm × 0.5 mm) and sampling depth (0–10 cm × 0–20 cm) on the description of infaunal communities, in an attempt to discuss standardized sampling procedures for different ecological studies objectives in these ecosystems. In general, the difference in sieve retention was less evident for biomass but was important for abundance: the 1.0 mm sieve retained only 27% of total individuals but 77% of total biomass. Regarding sampling depth, the 0–10 cm layer contained most individuals (94%) but contributed just 64% of the overall biomass. Although no strong differences in community structure were observed at most sites with the use of different sieves, the correlations among community dissimilarity using different meshes with environmental parameters (organic matter, total-N and microphytobenthos) indicated that the use of the 0.5 mm sieve will allow a better evaluation of the status of these estuaries. The results also highlight the importance of taking the vertical distribution of tropical macrofauna into account for quantitative estimates: for taxa composition and abundance the top layer is clearly essential, whereas for biomass the deeper layers should also be considered.
Decoding the “CoDe”: a framework for conceptualizing and designing help options in computer-based second language listening
Authors: Cardenas-Claros Monica Stella , Gruba Paul A. 
Published: March 2013

AbstractThis paper proposes a theoretical framework for the conceptualization and design of help options in computer-based second language (L2) listening. Based on four empirical studies, it aims at clarifying both conceptualization and design (CoDe) components. The elements of conceptualization consist of a novel four-part classification of help options: operational, regulatory, compensatory and explanatory. The design section establishes ways that make help options easy to use, encourage learner control, frame guidance and stimulate learning. Each component is contextualized, discussed and presented with limitations and suggestions for further research.
Identification of lifestyle patterns associated with obesity and fat mass in children: the Healthy Growth Study
Authors: Moschonis George , Kalliora Andriana C , Costarelli Vassiliki , Papandreou Christopher , Koutoukidis Dimitris , Lionis Christos , Chrousos George P , Manios Yannis 
Published: March 2013

AbstractObjectiveTo investigate possible associations of lifestyle patterns with obesity and fat mass in children.DesignCross-sectional epidemiological study. Principal component analysis was used to identify lifestyle patterns.SettingPrimary schools from four regions in Greece.SubjectsA total of 2073 schoolchildren (aged 9–13 years).ResultsChildren in the fourth quartile of the lifestyle pattern combining higher dairy foods with more adequate breakfast consumption were 39·4 %, 45·2 % and 32·2 % less likely to be overweight/obese and in the highest quartile of sum of skinfold thicknesses and fat mass, respectively, than children in the first quartile of this pattern. Similarly, children in the fourth quartile of a lifestyle pattern comprising consumption of high-fibre foods, such as fruits, vegetables and wholegrain products, were 27·4 % less likely to be in the highest quartile of sum of skinfold thicknesses than children in the first lifestyle pattern quartile. Finally, children in the fourth quartile of a lifestyle pattern characterized by more time spent on moderate-to-vigorous physical activity and more frequent meals were 38·0 %, 26·3 % and 29·5 % less likely to be overweight, centrally obese and in the highest quartile of fat mass, respectively, than their peers in the first quartile of this lifestyle pattern (allP< 0·05).ConclusionsThe current study identified three lifestyle patterns (i.e. one pattern comprising higher dairy consumption with a more adequate breakfast; a second pattern characterized by increased consumption of high-fibre foods; and a third pattern combining higher physical activity levels with more frequent meals), which were all related with lower odds of obesity and/or increased fat mass levels. From a public health perspective, promotion of these patterns among children and their families should be considered as one of the components of any childhood obesity preventive initiative.
Intake of game birds in the UK: assessment of the contribution to the dietary intake of lead by women of childbearing age and children
Authors: Taylor Caroline M , Golding Jean , Emond Alan M 
Published: March 2013

AbstractObjectiveConcern has recently been expressed about Pb levels in Pb-shot game meat. Our aim was to determine the consumption of game birds in a representative sample population in the UK, and in children and women of childbearing age in particular.DesignPopulation-based cross-sectional cohort study. Data from 4 d diet diaries from the UK National Diet and Nutrition Survey (NDNS; 2008–2010) were extracted to analyse data on game bird consumption in the sample population, in women of childbearing age (15–45 years old) and in children ≤6 years old.SettingHome-based study in representative areas of the UK.SubjectsParticipants in the NDNS (2008–2010; n 2126, age 1·5 to >65 years).ResultsFifty-eight participants (2·7 %) reported eating game birds. The mean intake was 19·5 (sd 18·1) g/d (median 15·6, range 1·3–92·9 g/d). In women of childbearing age (15–45 years), 11/383 (2·9 %) reported eating game birds, with a mean intake of 22·4 (sd 25·8) g/d (median 15·6, range 2·0–92·9 g/d). In children aged ≤6 years old, 3/342 (0·9 %) were reported as eating game birds, with a mean intake of 6·8 (sd 9·7) g/d (median 2·4, range 1·3–23·2 g/d).ConclusionsThe prevalence of consumption of game birds by women of childbearing age and children ≤6 years old was relatively low and intakes were small. However, any exposure to Pb in these two groups is undesirable. As are uncertainties about the ability of the diet diary method to capture the consumption of food items that are infrequently consumed, alternative methods of capturing these data should be used in future studies.
Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation
Authors: Meyer Daniela , Sielaff Frank , Hammami Maya , Böttcher-Friebertshäuser Eva , Garten Wolfgang , Steinmetzer Torsten 
Published: March 2013

TMPRSS2 (transmembrane serine proteinase 2) is a multidomain type II transmembrane serine protease that cleaves the surface glycoprotein HA (haemagglutinin) of influenza viruses with a monobasic cleavage site, which is a prerequisite for virus fusion and propagation. Furthermore, it activates the fusion protein F of the human metapneumovirus and the spike protein S of the SARS-CoV (severe acute respiratory syndrome coronavirus). Increased TMPRSS2 expression was also described in several tumour entities. Therefore TMPRSS2 emerged as a potential target for drug design. The catalytic domain of TMPRSS2 was expressed in Escherichia coli and used for an inhibitor screen with previously synthesized inhibitors of various trypsin-like serine proteases. Two inhibitor types were identified which inhibit TMPRSS2 in the nanomolar range. The first series comprises substrate analogue inhibitors containing a 4-amidinobenzylamide moiety at the P1 position, whereby some of these analogues possess inhibition constants of approximately 20 nM. An improved potency was found for a second type derived from sulfonylated 3-amindinophenylalanylamide derivatives. The most potent derivative of this series inhibits TMPRSS2 with a Ki value of 0.9 nM and showed an efficient blockage of influenza virus propagation in human airway epithelial cells. On the basis of the inhibitor studies, a series of new fluorogenic substrates containing a D-arginine residue at the P3 position was synthesized, some of them were efficiently cleaved by TMPRSS2.
What Influences Farm Size Growth? An Illustration in Southwestern France
Authors: Akimowicz Mikaël , Magrini Marie‐Benoît , Ridier Aude , Bergez Jacques‐Eric , Requier‐Desjardins Denis 
Published: March 2013

AbstractFarm size in industrialized countries grew significantly over the second half of the twentieth century. Using several econometric models, this article examines factors that influence farm size, the probability of an increase in farm size, and the intensity of farm growth. We find that farm structural characteristics, farmer's age, the existence of a successor, and spatial factors approximating urban influences have a significant impact on farm size, whereas human capital variables do not. This study considers a representative sample of 5,000 professional farms in the Midi‐Pyrénées region between 2000 and 2007.
Christian Reunion, the Anglo-French Alliance and the English Catholic Imagination, 1660–72
Authors: Glickman Gabriel 
Published: March 2013

Abstract
The Anglo-French Treaty of Dover has acquired notoriety due to its secret ‘Catholic’ clauses: the promised conversion of Charles II and the declared goal of reconciliation between the churches of England and Rome. Hitherto, these terms have been examined either as a cynical diplomatic gambit by Charles II or the start of a push towards catholic absolutism by a Stuart court faction. This article aims alternatively to locate the treaty within the ideological traditions of the English Catholic community, concentrating on the circle of priests and scholars connected to Lord Treasurer Thomas Clifford, whose writings incubated the vision of a grand reunion of Christendom. It argues that the new alliance was envisaged as an opportunity not merely to change the English religious settlement but to promote reform within the catholic world, unravelling Tridentine standards of uniformity to accommodate the practices of national churches. The project was designed to respond to trends in international diplomacy, to engage points of intellectual attraction between England and France, and, above all, to raise awareness of shared principles that could unite Gallican Catholicism with the Church of England. Yet the conception of French religion presented by the architects of the treaty was drawn out of encounters with an irenic minority within the Paris convents and seminaries, unrepresentative of the attitudes of church and state. As the treaty became exposed to public scrutiny, the disjuncture between this image and the reality embodied by Louis XIV brought serious implications for those English Catholics who had invested so heavily in the reputation of the kingdom of France.
Impact of Bran Addition on Water Properties and Gluten Secondary Structure in Wheat Flour Doughs Studied by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy
Authors: Bock Jayne E. , Connelly Robin K. , Damodaran Srinivasan 
Published: March 2013

ABSTRACTThe aim of this work was to elucidate the underlying physical mechanism(s) by which bran influences whole grain dough properties by monitoring the state of water and gluten secondary structure in wheat flour and bran doughs containing 35–50% moisture and 0–10% added bran. The system was studied with attenuated total reflectance (ATR) FTIR spectroscopy. Comparison of the OH stretch band of water in flour dough with that in H2O‐D2O mixtures having the same water content revealed the formation of two distinct water populations in flour dough corresponding to IR absorption frequencies at 3,600 and 3,200 cm–1. The band intensity at 3,200 cm–1, which is related to water bound to the dough matrix, decreased and shifted to lower frequencies with increasing moisture content of the dough. Addition of bran to the dough caused redistribution of water in the flour and bran dough system, as evidenced by shifts in OH stretch frequency in the 3,200 cm–1 region to higher frequencies and a reduction in monomeric water (free water). This water redistribution affected the secondary structure of gluten in the dough, as evidenced by changes in the second‐derivative ATR‐FTIR difference spectra in the amide I region. Bran addition caused an increase in β‐sheet content and a decrease in β‐turn (β‐spiral) content. However, this bran‐induced transconformational change in gluten was more significant in the 2137 flour dough than in Overley flour dough. This study revealed that when bran is added to flour dough, water redistribution among dough components promotes partial dehydration of gluten and collapse of β‐spirals into β‐sheet structures. This transconformational change may be the physical basis for the poor quality of bread containing added bran.
Phytophthora Crown and Root Rot of Zucchini Squash in Almería, Spain
Authors: Gómez J. , Pérez A. , Serrano Y. , Aguilar M. I. , Gómez R. 
Published: March 2013

Zucchini (Cucurbita pepo) is intensively cropped in approximately 4,500 ha of plastic houses in southern Spain. In 2008 to 2009, Consul, Cronos, and Tosca zucchini plants showed symptoms of leaf wilting, basal stem necrosis, and plant death. Incidences of dead plants were 20 to 30% and these plants were distributed in clusters. Phytophthora capsici Leonian was isolated from the basal stems of symptomatic plants, using PDA and cornmeal agar amended with a pimaricin, ampicillin, and rifampicin. Five resultant isolates (PCl-211, PCl-221, PCl-611, PCl-612, and PCl-811) on lima beans agar (LBA) produced white mycelia with lemon-shaped and papillate sporangia borne on long pedicels, but no oospores or chlamydospores. These isolates had an identical ribosomal DNA ITS sequence, matching with that of P. capsici in GenBank. The sequences of two representative isolates, PCl-211 and PCl-811, were deposited in GenBank with accession nos. KC662328 and KC688317, respectively. The pathogenicity of these five isolates was tested on zucchini cv. Consul in 1-liter containers filled with vermiculite in May and September of 2009. Plants were inoculated at the 2 to 3 true-leaf stage. Plates with LBA fully covered with colony of each isolate were separately blended and homogenized with 300 ml of sterile distilled water. Inocula were poured around stem at 50 ml per plant. Each experiment had three replicates and four plants per replicate. Treatments with different isolates were arranged in a randomized complete block design. In both experiments, 12 uninoculated plants served as controls. Test plants were maintained for a month following inoculation in a greenhouse with mean temperatures ranging from 21.9 to 27.9°C and from 20.7 to 24.6°C for the May and September experiments, respectively. The first wilting occurred 5 days after inoculation. At the end of the May experiment, all control plants and those inoculated with PCl-221 remained asymptomatic while 83.3% of those inoculated with PCl-211 and 100% of those with the other isolates were dead. Inoculated plants exhibited crown and root rots, excluding the secondary roots. In the September experiment, 83.3% and 33.3% of plants inoculated with PCl-211 and PCl-221, respectively, were symptomatic, while all plants inoculated with the other isolates were dead. The control plants remained healthy. The pathogen was consistently recovered from symptomatic plants in both experiments. Although P. capsici was reported in peppers (Capsicum annuum) in several provinces of Spain (1), to our knowledge, this is the first report of P. capsici as the causal agent of crown rot in zucchini plants in plastic houses in the Almería Province of Spain, one of the world's largest concentrations of greenhouses. Reference: (1) J. L. Andrés et al. Span J Agric Res 3:326, 2005.
Comparison of nutritional status of university students of two Asian countries
Authors: Muzaffar Ali Khan Khattak Muhammad , Draman Samsul , Khan Alam , Usman Khattak Muhammad 
Published: March 2013

PurposeThe purpose of this paper is to compare energy and macro‐nutrients intake in university hostel students in two countries of Asia.Design/methodology/approachFemale students from the hostels of International Islamic University, Malaysia (IIUM), Kuantan Campus and NWFP, Agricultural University Peshawar, Pakistan were assessed for energy and macro‐nutrients intake. A total of 140 students were registered who volunteered to participate in this study. The age range of the registered students was 22‐26 years. On the day of the registration, age, height and weight were recorded; also, food frequency questionnaires (FFQs) were provided. The participants were asked to record alternately for three days whatever they ate during the prescribed week. Out of 140 students 139 returned the FFQs. From the anthropometry, the BMI was used to assess the under, ideal, over‐weight and obese students. From the FFQs, energy and nutrient intakes were calculated using the food composition tables for Malaysia and Pakistan and compared with the recommended nutrients intakes (RNIs).FindingsThe body weight for the required height among the Malaysian students was lower by 7.81 per cent than the reference value, whereas the body weight of Pakistani students matched to the reference weight for height. The Malaysian students were 28.0, 61.0, 5.5 and 0.9 per cent under, ideal, over‐weight and obese, respectively, whereas Pakistani students were 100 per cent in the category of ideal‐body weight. The total energy consumption was higher among Malaysian students by 9.93 per cent compared to the reference requirements, whereas the Pakistani students claimed to meet the requirements. In terms of nutrients balancing the Malaysian students were having the ideal combination of the macro‐nutrients and it was within the recommended range of 55‐60, 15‐20 and 25‐30 per cent for carbohydrates, protein and fat, respectively; whereas the balancing of the macro‐nutrients was poor among the Pakistani students and met the energy requirements at the expense of fat consumption.Originality/valueThe paper suggests that there is imbalance in macro‐nutrients intake among the students.
Healthcare foodservice workers' knowledge of the dysphagia diet
Authors: Broz Charles C. 
Published: March 2013

PurposeThe purpose of this paper is to survey current nutrition/foodservice‐related healthcare professionals to determine their level of knowledge about dysphagia, and their perceptions of dysphagic patients and their needs.Design/methodology/approachA data collection instrument in the form of a questionnaire was developed to obtain an idea of the perceptions and knowledge‐level of diet/foodservice‐related healthcare workers about dysphagia. Subjects included foodservice workers, including food preparers and food deliverers at a large healthcare facility in the Southwestern United States. A total sample size of n=51 surveys was collected and analyzed.FindingsGiven the means from this sample group, healthcare foodservice workers are lacking in some areas of knowledge concerning dysphagia patients, and their dietary needs. Education and training seem indicated, as the number of patients suffering from some degree of dysphagia is only going to increase as the US population ages.Originality/valueMillions of Americans currently suffer from at least some degree of dysphagia. This number is expected to increase as the Baby Boomer generation reaches retirement age. The USA will be populated by more elderly people than ever before, and will thus host more individuals suffering from swallowing impairment. This paper adds insights to the subject.