bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel transformer attention‐based approach for sarcasm detection
Authors: Khan Shumaila , Qasim Iqbal , Khan Wahab , Aurangzeb Khursheed , Khan Javed Ali , Anwar Muhammad Shahid 
Published: July 2024

AbstractSarcasm detection is challenging in natural language processing (NLP) due to its implicit nature, particularly in low‐resource languages. Despite limited linguistic resources, researchers have focused on detecting sarcasm on social media platforms, leading to the development of specialized algorithms and models tailored for Urdu text. Researchers have significantly improved sarcasm detection accuracy by analysing patterns and linguistic cues unique to the language, thereby advancing NLP capabilities in low‐resource languages and facilitating better communication within diverse online communities. This work introduces UrduSarcasmNet, a novel architecture using cascaded group multi‐head attention, which is an innovative deep‐learning approach that employs cascaded group multi‐head attention techniques to enhance effectiveness. By employing a series of attention heads in a cascading manner, our model captures both local and global contexts, facilitating a more comprehensive understanding of the text. Adding a group attention mechanism enables simultaneous consideration of various sub‐topics within the content, thereby enriching the model's effectiveness. The proposed UrduSarcasmNet approach is validated with the Urdu‐sarcastic‐tweets‐dataset (UST) dataset, which has been curated for this purpose. Our experimental results on the UST dataset show that the proposed UrduSarcasmNet framework outperforms the simple‐attention mechanism and other state‐of‐the‐art models. This research significantly enhances natural language processing (NLP) and provides valuable insights for improving sarcasm recognition tools in low‐resource languages like Urdu.
The quality of the stepfather–child relationship in sole and joint physical custody
Authors: Steinbach Anja , Augustijn Lara , de Bel Vera 
Published: July 2024

AbstractObjectiveThis study examines whether the quality of the stepfather–child relationship differs among sole physical custody (SPC) and joint physical custody (JPC) families and compares the association between the father–child and the stepfather–child relationship across the two physical custody arrangements.BackgroundAn increasing number of families opt for JPC after separation or divorce. Because children in JPC families spend more time with their biological father than children in mother SPC families, the question arises whether JPC affects the quality of the stepfather–child relationship.MethodWe investigated 279 SPC and 182 JPC stepfather families with children aged 1 to 14 from the Family Models in Germany study. Ordinary least squares regression models and interaction effects were estimated.ResultsThe quality of the stepfather–child relationship was generally high in both SPC and JPC families and did not differ between the two arrangements. The father–child relationship was positively, albeit weakly, associated with the stepfather–child relationship in both arrangements, indicating spillover effects.ConclusionJPC does not affect the quality of the stepfather–child relationship.ImplicationsThis study does not provide any evidence that JPC is an ill‐suited physical custody arrangement when considering the quality of relationships in stepfamilies.
Resilience Against All Odds: How Refugee Women From Ukraine Find Courage Through Transnational Families
Authors: Dryjanska Laura , Sanchez Jamie N. , Hagues Rachel 
Published: July 2024

ABSTRACTThe recent war in Ukraine has prompted a global focus on refugees and their ability to successfully overcome adversity. This article focuses on the factors that foster resilience in women refugees. Refugee resilience depends on external environments as much as on internal strength, both of which relate to the nature of transnational families that stretch across at least two countries and rely on the family member's internal capacity to address the challenge of maintaining ties, alongside their external resources available in their circumstances. A qualitative study was conducted in November 2022 with 11 women refugees from Ukraine interviewed in Warsaw, Poland. Eight themes that contribute to resilience in women refugees were identified, including (1) family (in particular, intergenerational family solidarity), (2) community, (3) artistic expression and artisan creation, (4) connection to nature and environment, (5) access to mental health professionals, (6) work, (7) faith and spirituality and (8) hope for the future. Dominant, overarching narratives included the safety and well‐being of participants’ children, overcoming adversities for the sake of their sons and daughters and facing daily struggles related to providing for their family.
Enhanced Removal of Brine From Porous Structures by Supercritical CO2
Authors: Erramuspe Iris Beatriz Vega , Asafu‐Adjaye Osei , Rojas‐Márquez Melissa , Via Brian , Sastri Bhima , Banerjee Sujit 
Published: July 2024

AbstractSupercritical CO2 (sCO2) removes water from brine held in pumice stone at levels well above the solubility of water in sCO2. The higher water removal results from a combination of passive emulsification of water in sCO2 and viscous fingering of sCO2 through the saturated pumice. This leads to higher levels of salt deposition than that expected from solubility considerations alone. These deposits could impact the injectivity of sCO2 as well as its movement in the subsurface. The finding that the water concentration in sCO2 is not necessarily capped at the solubility limit should influence the parametrization of injection models.
Histopathological assessment of the viability of hepatic alveolar echinococcosis
Authors: Robers Selina , Reinehr Michael , Haibach Lillemor , Furrer Eva , Cincera Annina , Kronenberg Philipp Andreas , Eichenberger Ramon Marc , Deplazes Peter , Deibel Ansgar , Müllhaupt Beat , Weber Achim 
Published: July 2024

AimsInfections by the larval stage of the tape worms Echinococcus multilocularis and Echinococcus granulosus s.l. are potentially fatal zoonoses affecting humans as dead‐end hosts. Histopathological evaluation of hepatic echinococcosis is an integral part of patient management, including the distinction between alveolar (AE) and cystic echinococcosis (CE), which are associated with different disease courses and treatments. To improve histopathological assessment of Echinococcus lesions, we aimed to develop robust criteria to evaluate their viability and decay.Methods and resultsHistomorphological criteria for determining parasitic viability based on the morphology of parasite structures and different stages of their decay were defined based on a clinically and molecularly defined cohort comprising 138 specimens from 112 patients (59 AE and 53 CE); 618 AE lesions were assessed for histopathological viability comparing haematoxylin and eosin (H&E) staining with mAbEm18 and mAbEm2G11 immunostaining. Moreover, parasite viability was systematically mapped in cross‐sections of five additional AE lesions. Protoscoleces in CE and AE displayed variable states of degeneration. Albendazole had no significant effect on the morphology of parasite structures. Viability assessment revealed high agreement between H&E and mAbEm18, but not mAbEm2G11 staining, suggesting mAbEm18 staining as reliable for parasite viability assessment. H&E and mAbEm18 staining displayed a central–peripheral gradient of parasite viability and decay across parasitic lesions, with decayed cystic lesions located more towards the lesion centre while the most viable cystic lesions were located more peripherally.ConclusionsHistopathological criteria corroborated by mAbEm18 staining provide a simple and reliable tool to assess the viability of AE lesions, knowledge of which is a valuable decision‐making tool for further treatment.
Clinicopathologic and molecular study of superficial CD34‐positive fibroblastic tumours mimicking atypical fibrous histiocytoma (dermatofibroma)
Authors: Wakefield Craig B , Mertens Fredrik , Fletcher Christopher D M , Anderson William J 
Published: July 2024

AimsSuperficial CD34‐positive fibroblastic tumour (SCD34FT) is an uncommon but distinctive low‐grade neoplasm of the skin and subcutis that shows frequent CADM3 expression by immunohistochemistry (IHC). In this study, prompted by an index case resembling ‘atypical fibrous histiocytoma (FH)’ that was positive for CADM3 IHC, we systematically examined a cohort of tumours previously diagnosed as ‘atypical FH’ by applying CADM3 and fluorescence in situ hybridization (FISH) for PRDM10 rearrangement, to investigate the overlap between these tumour types.Methods and ResultsForty cases of atypical FH were retrieved, including CD34‐positive tumours (n = 20) and CD34‐negative tumours (n = 20). All tumours were stained for CADM3. All CADM3‐positive tumours were evaluated by FISH to assess for PRDM10 rearrangement. Eleven CD34‐positive tumours (11/20, 55%) coexpressed CADM3 and were reclassified as SCD34FT. None (0/20) of the CD34‐negative atypical FH were CADM3‐positive. Reclassified SCD34FT (10/11) arose on the lower extremity, with frequent involvement of the thigh (n = 8). Features suggestive of atypical FH were observed in many reclassified cases including variable cellularity, spindled morphology, infiltrative tumour margins, collagen entrapment, epidermal hyperpigmentation, and acanthosis. Variably prominent multinucleate giant cells, including Touton‐like forms, were also present. An informative FISH result was obtained in 10/11 reclassified tumours, with 60% (6/10) demonstrating PRDM10 rearrangement.ConclusionA significant subset of tumours that histologically resemble atypical FH, and are positive for CD34, coexpress CADM3 and harbour PRDM10 rearrangement, supporting their reclassification as SCD34FT. Awareness of this morphologic overlap and the application of CADM3 IHC can aid the distinction between SCD34FT and atypical FH.
Proanthocyanidin surface preconditioning of dental pulp stem cell spheroids enhances dimensional stability and biomineralization in vitro
Authors: Yang Shengyan , Leung Andy Yu Pan , Wang Zheng , Yiu Cynthia Kar Yung , Dissanayaka Waruna Lakmal 
Published: July 2024

AbstractAimLack of adequate mechanical strength and progressive shrinkage over time remain challenges in scaffold‐free microtissue‐based dental pulp regeneration. Surface collagen cross‐linking holds the promise to enhance the mechanical stability of microtissue constructs and trigger biological regulations. In this study, we proposed a novel strategy for surface preconditioning microtissues using a natural collagen cross‐linker, proanthocyanidin (PA). We evaluated its effects on cell viability, tissue integrity, and biomineralization of dental pulp stem cell (DPSCs)‐derived 3D cell spheroids.MethodologyMicrotissue and macrotissue spheroids were fabricated from DPSCs and incubated with PA solution for surface collagen cross‐linking. Microtissue viability was examined by live/dead staining and 3‐(4,5‐dimethylthiazol‐2‐yl)−2,5‐diphenyltetrazolium bromide (MTT) assay, with transverse dimension change monitored. Microtissue surface stiffness was measured by an atomic force microscope (AFM). PA‐preconditioned microtissues and macrotissues were cultured under basal or osteogenic conditions. Immunofluorescence staining of PA‐preconditioned microtissues was performed to detect dentin sialophosphoprotein (DSPP) and F‐actin expressions. PA‐preconditioned macrotissues were subjected to histological analysis, including haematoxylin–eosin (HE), alizarin red, and Masson trichrome staining. Immunohistochemistry staining was used to detect alkaline phosphatase (ALP) and dentin matrix acidic phosphoprotein 1 (DMP‐1) expressions.ResultsPA preconditioning had no adverse effects on microtissue spheroid viability and increased surface stiffness. It reduced dimensional shrinkage for over 7 days in microtissues and induced a larger transverse‐section area in the macrotissue. PA preconditioning enhanced collagen formation, mineralized nodule formation, and elevated ALP and DMP‐1 expressions in macrotissues. Additionally, PA preconditioning induced higher F‐actin and DSPP expression in microtissues, while inhibition of F‐actin activity by cytochalasin B attenuated PA‐induced dimensional change and DSPP upregulation.ConclusionPA surface preconditioning of DPSCs spheroids demonstrates excellent biocompatibility while effectively enhancing tissue structure stability and promoting biomineralization. This strategy strengthens tissue integrity in DPSC‐derived spheroids and amplifies osteogenic differentiation potential, advancing scaffold‐free tissue engineering applications in regenerative dentistry.
Dynamic bending analysis of metallized silicon nitride substrate during thermal cycling via digital image correlation
Authors: Ngo Minh Chu , Miyazaki Hiroyuki , Hirao Kiyoshi , Ohji Tatsuki , Fukushima Manabu 
Published: July 2024

AbstractDigital image correlation (DIC) method was employed to analyze the dynamic bending of a metallized Si3N4 substrate in thermal cycles ranging from −40°C to 250°C. The substrate was monitored by DIC over several consecutive cycles, spanning from 0 to 2501. Three DIC measurement intervals, specifically during 999–1001, 1999–2001, and 2499–2501 cycles, were selected to analyze the bending behavior in response to temperature fluctuations. By the scanning acoustic microscope (SAM), the substrate revealed negligible delamination after 1001 cycles, light delamination after 2001 cycles, and serious delamination post‐2501 cycles. The dynamic bending remained unchanged during 999–1001 cycles. A curve with a negative bending was observed during 1999–2001 cycles, with a peak curvature of .024 mm−1 at −40°C; the negative bending intensified with a curvature reaching .050 mm−1 at −40°C during 2499–2501 cycles. The bending curve then decreased during the heating phase and returned to a non‐bent state at elevated temperatures. The bending curve reversed to positive at 250°C during thermal cycles from 2499 to 2501. The bending behavior throughout thermal cycles was discussed in relation to the asymmetric delamination observed on both sides of the substrate, as well as the distribution of delamination.
Viscous crack healing in soda–lime–magnesium–silicate–ZrO2 glass matrix composites
Authors: Blaeß Carsten , Müller Ralf 
Published: July 2024

AbstractThe present study investigates the influence of the crystal volume content on viscous crack healing in glass ceramic glass sealants. To ensure constant microstructure during healing, soda–lime–magnesium silicate glass matrix composites with varied volume fractions of ZrO2 filler particles were used. Crack healing was studied on radial cracks induced by Vickers indentation, which were stepwise annealed to monitor the healing progress by confocal laser scanning microscopy. Confirming previous studies, healing of radial cracks in pure glass was found delayed by global flow phenomena like crack widening and crack edge and tip rounding to minimize the sample surface. With increasing ZrO2 filler content, these global flow phenomena were progressively inhibited whereas local flow phenomena like sharp crack tip healing could still occur. As a result, crack healing was even accelerated by filler particles up to a maximum filler content of 17 vol% whereas crack healing was fully suppressed only at 33 vol% filler content.
Selective laser sintering and spark plasma sintering of (Zr,Nb,Ta,Ti,W)C compositionally complex carbide ceramics
Authors: Trinh Lanh , Hua Zilong , Bawane Kaustubh , He Lingfeng , Malakkal Linu , Chen Xin , Wadle Luke , Lu Yongfeng , Cui Bai 
Published: July 2024

AbstractTwo advanced manufacturing processes, spark plasma sintering (SPS) and selective laser sintering (SLS), have been developed for synthesis of (Zr,Nb,Ta,Ti,W)C compositionally complex carbide (CCC) via reactive sintering of a powder mixture of constitute monocarbides. X‐ray diffraction analysis confirmed that the single‐phase CCC can be formed by both SPS and SLS. While a homogenous microstructure with uniform metal element distributions was developed during SPS, three‐layer microstructures with a thin TiC‐rich layer and two TaC‐rich layers along with a TiO2‐rich surface layer containing W nanoparticles were formed during SLS. In addition, cellular structures with W, Zr, and Ti element segregation and dislocations on cell boundaries were observed in the SLS‐CCC sample, indicating the effect of nonequilibrium conditions on microstructure formation during laser melting followed by rapid cooling and solidification process. Compared to the SPS‐CCC sample, the SLS‐CCC showed enhanced hardness and reduced thermal conductivity, which may be related to their unique cellular structures.
Binary transition metal oxide: A novel and efficient catalyst for the synthesis of boron nitride nanotubes
Authors: Wang Heng , Zhu Tianbin , Dai Yajie , Sang Shaobai , Li Yawei , Fu Zhengyi 
Published: July 2024

AbstractA novel binary transition metal oxide (NiFe2O4) nanosphere catalyst with a diameter of 500 nm has been synthesized by the hydrothermal reaction, which can efficiently catalyze the formation of hexagonal boron nitride nanotubes (BNNTs) with high‐yield and large aspect ratio. Based on the temperature dependence of the product phase composition and microstructure, combined with results generated using single‐component catalysts, the BNNTs formation process can be summarized as follows: NiFe2O4 reacts with NH3 to generate Fe0.64Ni0.36, which dissolves to form a liquid‐phase Ni‐Fe alloy at high temperatures, where the B component in the precursor and the N atom formed by the decomposition of NH3 diffuse on the surface of the Ni‐Fe alloy; when the concentration of B and N exceed the saturation threshold, hollow BNNTs containing catalyst at the tips are precipitated. The formation process is dominated by a vapor‐liquid‐solid mechanism with tip‐growth mode, where the synergistic catalytic effect of the Ni‐Fe binary system promotes a high yield of large aspect ratio BNNTs.
Novel candidate metastasis‐associated genes for synovial sarcoma
Authors: Zhao Zhiqing , Niu Jianfang , Wang Jichuan , Zhang Ranxin , Liang Haijie , Ma Yingteng , Ferrena Alexander , Wang Wei , Yang Rui , Geller David S. , Guo Wei , Ren Tingting , Hoang Bang H. , Tang Xiaodong , Yan Taiqiang 
Published: July 2024

AbstractSynovial sarcoma (SS) is an aggressive soft tissue sarcoma with poor prognosis due to late recurrence and metastasis. Metastasis is an important prognostic factor of SS. This study aimed to identify the core genes and mechanisms associated with SS metastasis. Microarray data for GSE40021 and GSE40018 were obtained from the Gene Expression Omnibus database. 186 differentially expressed genes (DEGs) were identified. The biological functions and signalling pathways closely associated with SS metastasis included extracellular matrix (ECM) organization and ECM‐receptor interaction. Gene set enrichment analysis showed that the terms cell cycle, DNA replication, homologous recombination and mismatch repair were significantly enriched in the metastasis group. Weighted gene co‐expression network analysis identified the most relevant module and 133 hub genes, and 31 crossover genes were identified by combining DEGs. Subsequently, four characteristic genes, EXO1, NCAPG, POLQ and UHRF1, were identified as potential biomarkers associated with SS metastasis using the least absolute shrinkage and selection operator algorithm and validation dataset verification analysis. Immunohistochemistry results from our cohort of 49 patients revealed visible differences in the expression of characteristic genes between the non‐metastatic and metastatic groups. Survival analysis indicated that high expression of characteristic genes predicted poor prognosis. Our data revealed that primary SS samples from patients who developed metastasis showed activated homologous recombination and mismatch repair compared to samples from patients without metastasis. Furthermore, EXO1, NCAPG, POLQ and UHRF1 were identified as potential candidate metastasis‐associated genes. This study provides further research insights and helps explore the mechanisms of SS metastasis.
The effect of the HMGB1/RAGE/TLR4/NF‐κB signalling pathway in patients with idiopathic epilepsy and its relationship with toxoplasmosis
Authors: Soytürk Hayriye , Önal Cansu , Kılıç Ümit , Türkoğlu Şule Aydın , Ayaz Erol 
Published: July 2024

AbstractThis study aims to investigate the relationship between toxoplasmosis and this pathway, which may be effective in the formation of epilepsy by acting through the HMGB1/RAGE/TLR4/NF‐κB signalling pathway in patients with idiopathic epilepsy. In the study, four different experimental groups were formed by selecting Toxoplasma gondii IgG positive and negative patients with idiopathic epilepsy and healthy controls. Experimental groups were as follows: Group 1: Epilepsy+/Toxo− (E+, T−) (n = 10), Group 2: Epilepsy−/Toxo− (E−, T−) (n = 10), Group 3: Epilepsy−/Toxo+ (E−, T+) (n = 10), Group 4: Epilepsy+/Toxo+ (E+, T+) (n = 10). HMGB1, RAGE, TLR4, TLR1, TLR2, TLR3, IRAK1, IRAK2, IKBKB, IKBKG, BCL3, IL1β, IL10, 1 L8 and TNFα mRNA expression levels in the HMGB/RAGE/TLR4/NF‐κB signalling pathway were determined by quantitative simultaneous PCR (qRT‐PCR) after collecting blood samples from all patients in the groups. Statistical analysis was performed by one‐way ANOVA followed by LSD post‐hoc tests, and p < 0.05 was considered to denote statistical significance. The gene expression levels of HMGB1, TLR4, IL10, IL1B, IL8, and TLR2 were significantly higher in the G1 group than in the other groups (p < 0.05). In the G3 group, RAGE and BCL3 gene expression levels were significantly higher than in the other groups (p < 0.05). In the G4 group, however, IRAK2, IKBKB, and IKBKG gene expression levels were significantly higher than in the other groups (p < 0.05). HMGB1, TLR4, IRAK2, IKBKB, IL10, IL1B, IL1B, and IL8 in this signalling pathway are highly expressed in epilepsy patients in G1 and seizures occur with the stimulation of excitatory mechanisms by acting through this pathway. The signalling pathway in epilepsy may be activated by HMGB1, TLR4, and TLR2, which are considered to increase the level of proinflammatory cytokines. In T. gondii, this pathway is activated by RAGE and BCL3.
Summary data‐based Mendelian randomization and single‐cell RNA sequencing analyses identify immune associations with low‐level LGALS9 in sepsis
Authors: Yang Yongsan , Dong Lei , Li Yanguo , Huang Ye , Zeng Xiaoxi 
Published: July 2024

AbstractSepsis is one of the major challenges in intensive care units, characterized by the complexity of the host immune status. To gain a deeper understanding of the pathogenesis of sepsis, it is crucial to study the phenotypic changes in immune cells and their underlying molecular mechanisms. We conducted Summary data‐based Mendelian randomization analysis by integrating genome‐wide association studies data for sepsis with expression quantitative trait locus data, revealing a significant decrease in the expression levels of 17 biomarkers in sepsis patients. Furthermore, based on single‐cell RNA sequencing data, we elucidated potential molecular mechanisms at single‐cell resolution and identified that LGALS9 inhibition in sepsis patients leads to the activation and differentiation of monocyte and T‐cell subtypes. These findings are expected to assist researchers in gaining a more in‐depth understanding of the immune dysregulation in sepsis.