bluuebunny/crossref_metadata_2025_split huggingface dataset:
A CASE OF MALIGNANT LYMPHOMA OF THE NODULAR, POORLY DIFFERENTIATED LYMPHOCYTIC TYPE
Authors: Igarashi Minoru , Katoh Taizo , Seiji Makoto , Abe Masao 
Published: April 2015

ABSTRACTA case of malignant lymphoma of the nodular, poorly differentiated lymphocytic type was presented. The patient, a 72‐year‐old woman, exhibited cutaneous nodules, generalized lymphadenopathy and splenomegaly. Treatment with two courses of steroid therapy and radiotherapy was carried out. After this therapy, skin tumors responded excellently. Histopathological findings of lymph nodes included proliferating forms of lymphoid tumor cells consisting of nodular and diffuse patterns. Peripheral lymphoid tumor cells, which had cleaved nuclei, clear nucleoli and mitoses were 30% increased in peripheral lymphocytes. Furthermore, the percentage of B cells in the subpopulation of peripheral lymphocytes was high, and that of T cells was low.In the present report, the histopathological and autopsy findings were studied, and some aspects of the classification of malignant lymphoma were discussed.
PLAQUE TYPE SYRINGOMA
Authors: Kikuchi Ichiro , Idemori Masahiro , Okazaki Michiharu 
Published: April 2015

ABSTRACTSpecial types of syringoma include eruptive syringoma (1) and syringoma on the vulva and on the upper extremities (2). We present a large one, 1×5 cm in size, found on the right side of the neck, and preoperatively diagnosed as nevus sebaceus.
CLINICAL SIGNIFICANCE AND CORRELATION OF ANTI‐NATIVE DNA ANTIBODIES AND IMMUNE COMPLEX LEVEL IN SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Deng Jau‐Shyong , Lü Yau‐Chin , Shieh Shiow‐Hua 
Published: April 2015

ABSTRACTThe clinical significance and correlation of anti‐native DNA antibodies and immune complex level were evaluated in the present study. Anti‐DNA antibodies were measured by radioimmunoassay using I125‐labeled DNA and immune complex was screened using the polyethylene glycol precipitation method. Anti‐DNA antibodies of higher than 40 units/ml were found exclusively in patients with systemic lupus erythematosus, especially in patients with lupus nephritis. The level of anti‐DNA antibodies was found to be directly correlated with the disease activity. Higher amounts of circulating immune complexes could be found in patients with systemic lupus erythematosus, vasculitis, and other diseases. The patients with more active lupus erythematosus also tended to have higher amounts of immune complexes, but the correlation was not so definite. There was also no reliable correlation between anti‐DNA activity and immune complex level.
TREATMENT OF PEMPHIGUS WITH CORTICOSTEROIDS AND CYCLOPHOSPHAMIDE
Authors: Piamphongsant Thada 
Published: April 2015

ABSTRACTAn initial combination of moderated doses of prednisone or prednisolone and cyclophosphamide seemed to be rapidly effective in controlling pemphigus vulgaris and pemphigus foliaceus with minimal side effects. An appropriate schedule of treatment is proposed. The clinical response correlated very well with the decreased titers of pemphigus antibodies which became negative within six months. Elevated serum immunoglobulin levels returned to normal in most of the cases.
DETECTION AND QUANTITATION OF 5‐S‐CYSTEINYLDOPA IN MELANOTIC AND AMELANOTIC MELANOMA IN COMPARISON WITH NONPIGMENT CELL TUMORS AND IT'S URINARY EXCRETION
Authors: Mojamdar Manoj , Ichihashi Masamitsu , Mishima Yutaka 
Published: April 2015

ABSTRACTRecent investigations have shown that two major catechols, 5‐S‐cysteinyldopa and dopa are formed during melanogenesis. 5‐S‐cysteinyldopa has been shown to play a role in pheomelanogensis. The levels of 5‐S‐cysteinyldopa were estimated in tumors and urine of melanoma patients and were compared with those of non‐melanoma subjects. All melanotic melanomas, both primary and metastatic, contained substantial amounts of 5‐S‐cysteinyldopa. Urinary excretion of 5‐S‐cysteinyldopa increased with the duration of melanoma. The clinical and biological significance of 5‐S‐cysteinyldopa levels in estimating the extent of metastasis are discussed together with other clinical data from melanoma subjects.
NEVOID BASAL CELL EPITHELIOMA SYNDROME IN JAPAN
Authors: Tanaka Masasuke , Ohtsuka Toshio , Iwata Katsumi , Ueda Naoki , Kumano Osamu , Arase Seiji 
Published: April 2015

ABSTRACTA 49‐year‐old Japanese man with typical features of nevoid basal cell epithelioma syndrome is reported. The patient had cystic lesions of the jaw bone, multiple basal cell epitheliomas of the scalp and face, pits on the palms and soles, bifid ribs, scoliosis and calcification of the falx cerebri. In Japan five certain cases have been reported previously. We added one new case and reviewed the other five cases briefly.
INCONTINENTIA PIGMENTI ACHROMIANS (ITO)
Authors: Hata Seiichiro , Endo Hidehiko , Yabuuchi Hyakuji 
Published: April 2015

ABSTRACTA patient with incontinentia pigmenti achromians was reported. She displayed other abnormalities such as a saddle nose, malformed auricles, growth retardation, convulsions and abnormal EEG. Histopathologically, a partial decrease in melanin granules in the basal layer and the presence of melanocytes which showed a weak dopa reaction were the main findings. The hypo‐function of melanin production was detected by electron microscopy.
STUDIES ON THE QUANTITY AND CHEMICAL COMPOSITION OF SURFACE LIPIDS OF HUMAN SCALP AND HAIR
Authors: Okamoto Kikuhiko 
Published: April 2015

ABSTRACTThe quantity and chemical composition of the surface lipids of the normal female scalp and hair were studied.

Testing materials were obtained from 64 normal females as experimental objects. Lipids were extracted with acetone‐ether for quantity measurement using the weight method and thin‐layer chromatographic analysis, and for chemical composition using both thin‐layer chromatographic analysis and a mass spectrometer linked directly with gas chromatography (gas‐mass method).
Quantities and compositions of surface lipids of the scalp fluctuated in accordance with the methods adopted to cleanse the hair and the volume of cleansing agents used.
Twenty four hours after cleansing the scalp and removal of surface lipids, it was observed that the volume of lipids had been restored to pre‐cleansing levels. These restored lipids had been significantly hydrolysed after 24 hours, to the point where lipase should seemingly affect them.
The level of free fatty acids corresponded to the quantity of total lipids and exceeded the level of triglycerides after 24–48 hours, when the quantity of restored lipids had increased and hydrolysed. Some of those sampled complained of scalp itchiness.
The volume of scalp surface lipids is obviously affected by seasonal factors related to conditions of cleansing constancy; i. e., it was greatest in May and least in July.
Most of the hair's surface lipids have been transferred there after first appearing on the surface of the scalp and being hydrolysed, while smaller quantities of these lipids are transferred directly from sebaceous glands to the hair.
AN ACQUIRED FORM OF ACRODERMATITIS ENTEROPATHICA DUE TO LONGTERM LACTOSE‐FREE MILK ALIMENTATION
Authors: Morishima Takafumi , Yagi Shigeru , Kuwabara Kyosuke , Endo Mikio , Takemura Tsukasa 
Published: April 2015

ABSTRACTA 4‐month‐old boy, fed on lactose‐free milk for the treatment of intractable diarrhea for about 3 months, developed acrodermatitis enteropathica‐like skin lesions. All the symptoms dramatically disappeared 2 weeks after switching from this milk to a general cow's milk formula, and his low serum zinc level also rapidly returned to normal. The zinc deficiency seen in this case was presumed to be closely related to longterm lactose‐free milk alimentation. Acrodermatitis enteropathica, a human zinc deficiency, should be classified into two types, hereditary and acquired. The latter form can develop from intravenous hyperalimentation, longterm lactose‐free milk alimentation and longterm penicillamine administration.
NODULAR FASCIITIS
Authors: Kikuchi Ichiro , Hiejima Mutsusuke , Inoue Shohei 
Published: April 2015

ABSTRACTA 53‐year‐old Japanese male construction worker developed a hard mass subcutaneously on the right thigh 2 months prior to first examination. Biopsy of a small part of the lesion was followed by moderate inflammation at the lesion, associated with regional lymphadenopathy. By the time the inflammation subsided, the mass had reduced in size. IgE was elevated, and the delayed type hypersensitivity was increased after the inflammation. The mechanism of spontaneous regression of nodular fasciitis, unclarified at present, should be studied in further cases.
PHOTOSENSITIVITY DUE TO HYDROCHLOROTHIAZIDE
Authors: Torinuki Wakio 
Published: April 2015

ABSTRACTA case of photosensitivity induced by only 2 tablets of hydrochlorothiazide (Behyd‐RA tablets) is reported. The patient had sunburn‐like eruptions on the face, neck, arms and hands. The histologic picture was the same as in polymorphic light eruption. Black light irradiation could induce the same reaction clinically as well as histologically. The patient had an identical history five years previously. A rapid improvement of the lesions occurred after cessation of the hydrochlorothiazide administration and avoidance of exposure to sunlight. No photosensitive reactions have been noted since. The skin reaction of this case was due to long ultraviolet light and hydrochlorothiazide, and possibly photoallergic in nature.
PAPULAR ACRODERMATITIS OF CHILDHOOD (GIANOTTI'S DISEASE)
Authors: Takata Minoru , Fukui Yonemasa , Taketani Tokuo , Nakamura Yoichi 
Published: April 2015

ABSTRACTTwo cases of papular acrodermatitis of childhood (Gianotti's disease) are reported. Characteristic skin lesions and acute anicteric hepatitis associated with hepatitis B surface antigenemia were observed in each case. Subtype analysis of hepatitis B surface antigen (HBs‐Ag) disclosed “adr” and “adw” respectively, which prevail among Japanese asymptomatic carriers. Intrafamilial father‐to‐child transmission of HB virus was strongly suspected in case 2. HBs‐Ag disappeared from the serum after three months in case 1, but persisted in case 2, who also developed chronic persistent hepatitis.
GRAFT VERSUS HOST REACTION
Authors: Mohri Shinobu , Otsuki Norio , Takada Minoru , Kawashima Yoshio , Kodo Hideki 
Published: April 2015

ABSTRACTA 27‐year‐old man with acute lymphocytic leukemia (ALL) received a bone marrow transplant (BMT). On day 27, he developed erythematous maculopapular lesions all over his body. This rash improved within a month. Histological findings were obtained comparing those of the graft versus host reaction (GVHR).Five months later, he developed macular lesions on his body, clinically suggestive of lichen planus. Histologically, it was also compatible with lichen planus.He exhibited the grade I changes of acute GVHR described in Lerner's classification, and lichen planus‐like eruptions as the chronic form.
HERPETIFORM PEMPHIGUS‐LIKE SKIN LESIONS INDUCED BY D‐PENICILLAMINE
Authors: Morioka Shinji , Ogawa Hideoki 
Published: April 2015

ABSTRACTHerpetiform pemphigus‐like skin lesions appeared on a patient with rheumatoid arthritis who had been treated with D‐penicillamine. The pemphigus‐like antibodies reacted with normal human skin specimens at a titer of 1:5 serum dilution; however, the antibodies reacted more intensely with specimens of other's D‐penicillaminized skins and the patient's own skin. All of these skin lesions and abnormal antibodies disappeared after D‐penicillamine therapy was halted. In this patient, the pemphigus‐like antibodies might be induced by the drug with resulting skin lesions.
AN OUTBREAK OF PCB POISONING
Authors: Lee Yu‐Yun , Wong Pin‐Nan , Lü Yau‐Chin , Sun Chee‐Ching , Wu Ying Chin , Un Ruey‐Yi , Jee Shiou‐Hwa , Ng Kei‐Yam , Yeh Hsu‐Po 
Published: April 2015

ABSTRACTAn outbreak of poisoning, characterized clinically by hyperpigmentation and a chloracne‐like eruption, broke out in mid‐Taiwan in Feburary 1979. Probably over a thousand persons were affected. The source of poisoning was found to be a specific brand of rice bran oil which was contaminated accidentally with polychlorinated biphenyls (PCB). PCB was detected from suspected oil samples in concentrations of 40 to 106 ppm. The blood PCB levels were 70 to 460 ppb in some patients. The amount of oil consumed by the individual patients was approximately one liter per month.A total of 358 cases of suspected rice bran oil poisoning was seen in the special clinics of Provincial Taichung Hospital and National Taiwan University Hospital. There were 171 males and 187 females, aged between 7 days and 78 years. Half of the patients were aged 11 to 30 years. One hundred and twenty‐three patients were from families and the rest were groups from Hwei‐Ming Blind School, factories, and temples.In general, the age distribution of the patients, the symptomatology, the skin pathology and the way the poisoning occurred, were similar to those of Yusho patients. However, differences were noted in some clinical signs, namely a higher incidence of hyperpigmentation and a lower incidence of acneform eruption in our series when compared with Goto's series. It is speculated that this may be partly due to different isomers or concentrations of PCB in the blood and tissues.
THE EFFECT OF VITAMIN A DERIVATIVES ON DIGESTIVE GLANDS OF RATS
Authors: Lee Jung Bock , Lee Sungnack , Kim Won Joon , Hong Sa Suk 
Published: April 2015

ABSTRACTThe effects of toxic doses of vitamin A and its derivatives on the exocrine functions of the liver, pancreas and stomach of rats were observed. Vitamin A, retinoic acid or retinoid, an aromatic analog of retinoic acid, was given orally in a single large dose or in repeated doses. Excessive feeding of vitamin A or its derivatives, particularly retinoic acid, caused considerable toxicity and a change in the exocrine functions of the digestive glands. The mortality was high (37.5%) in rats treated with retinoic acid. Only one of 40 rats died in the retinoid group and none in the vitamin A or the control groups. The rats treated with retinoic acid or retinoid lost weight but recovered within 2 weeks after the completion of treatment.
MIXED CONNECTIVE TISSUE DISEASE
Authors: Miyagawa Sachiko , Iioka Akiko , Iwai Michiko , Sakamoto Kuniki , Tomii Masakuni 
Published: April 2015

ABSTRACTElevated levels of circulating soluble immune complexes were found in the serum of a patient with mixed connective tissue disease. They correlated well with clinical disease activity and with the course of the patient. Moderate doses of betamethasone reduced the levels of immune complexes and led to clinical improvement.
COMPARATIVE STUDY OF THE SENSITIVITY OF HERPES SIMPLEX VIRUS TYPES 1 AND 2 TO HUMAN LEUKOCYTE INTERFERON IN VITRO
Authors: Matsubara Motoo , Imanishi Jiro , Yasuno Hirokazu , Kagami Kiyoshi , Ozaki Yoshikatsu , Pak Chin‐Bin , Kishida Tsunataro 
Published: April 2015

ABSTRACTIn order to examine the sensitivity of Herpes simplex virus (HSV) types 1 and 2 (nine strains were used) to human leukocyte interferon (HL‐IF), human embryonic fibroblast (HEF) cultures were treated with 1 times 104 IU of HL‐IF 24 hrs before each HSV was inoculated. Forty‐eight and seventy‐two hours after incubation at 37°C in a 5% CO2 atmosphere, cytopathogenic effect (CPE) or giant cell formation by HSV was observed. The TCID50 in control cultures was compared with that in IF‐treated cultures. Although HL‐IF could protect cell culture against HSV infection, no differences in sensitivity between the two types of HSV or among the nine strains of HSV to HL‐IF were recognized.
SCLEROMYXEDEMA
Authors: Sawada Yoko , Ohashi Masaru 
Published: April 2015

ABSTRACTAn investigation of the relationship between depositions of immunoglobulin or complement and hyaluronic acid in cutaneous lesions of a patient with scleromyxedema was undertaken.In sections of unfixed tissue examined by the immunofluorescence technique, IgG deposits were demonstrated chiefly in the reticular layer of the corium whereas an intense fluorescence for IgG and C3 was observed in pericellular regions.Histochemical observations revealed abnormal hyaluronic acid deposits in the cutaneous lesion. When treated with ascorbic acid for hyaluronic acid depolymerization, the substance positive for alcian blue almost completely disappeared, as did the IgG.
HISTOLOGICAL AND SEROLOGICAL STUDIES OF PITYROSPORUM ORBICULARE IN CASES OF PITYRIASIS VERSICOLOR
Authors: Furukawa Fukumi , Danno Kiichiro , Imamura Sadao , Soh Yoshiro 
Published: April 2015

ABSTRACTThe antibody titer to Pityrosporum orbiculare of 40 patients with pityriasis versicolor was measured using both the sensitized hemagglutinin method and the immunofluorescence antibody technique. Among the patients there was no significant correlation between the antibody titer and the lesional duration, distribution, color, or the presence or absence of the itching. When compared with the antibody titer of 31 healthy volunteers, no significant differences between the groups were found. In 18 out of the 40 patients, biopsy specimens were prepared for light microscopy and direct immunofluorescence microscopy. Acanthosis was observed in 13 specimens but no deposits of immunoglobulin or complement were noted.
PROTECTIVE EFFECTS OF INTERFERON, VARIOUS ANTI‐VIRAL DRUGS AND COMBINATIONS OF THESE ON HERPES SIMPLEX VIRUS INFECTION IN MICE
Authors: Matsubara Motoo 
Published: April 2015

ABSTRACTYoung adult mice were inoculated intraperitoneally with 30LD50 of Herpes simplex virus type 1 (Miyama strain). They died within 14 days after the inoculation. Mice were equally protected by intraperitoneal injection of L cell interferon (L‐IF) or mouse brain IF (MB‐IF) given 1 day before, simultaneously and 1 day after the viral inoculation. Mice were also protected when 100μg of polyinosinic acid‐polycytidylic acid (Poly I:C) was given intraperitoneally 1 day before the viral inoculation or on the same day, but not if given on the following day. When adenine arabinoside (ara‐A) was administered every day from the 1st to the 4th day after the viral inoculation, the protective effect also occurred. However, lipopolysaccharide (LPS), amphotericin B methyl ester (AME) and gamma globulin (GG) were ineffective in reducing mortality. The protective effect could be also demonstrated by combining poly I:C and L‐IF at doses which were individually ineffective. On the other hand, no synergism between L‐IF and ara‐A was observed.
IMMUNOPATHOLOGICAL STUDY ON PERILESIONAL PEMPHIGUS SKIN
Authors: Yamasaki Yuuichiro 
Published: April 2015

ABSTRACTSeven perilesional skin samples which appeared to be normal were obtained from patients with pemphigus and studied by means of direct immunofluorescence and horseradish peroxidase labeled antibody methods. Light microscopic observations revealed that in vivo bound IgG and C3 were localized in the intercellular cement substance region of the epidermis in both the direct immunofluorescence and horseradish peroxidase labeled antibody method in exactly the same fashion. Immunoelectronmicroscopic observations revealed that bound IgG and C3 were localized exclusively in the epidermal intercellular cement substance region, but not in any intracellular organellae, pinocytotic vesicles, cytosol, basal lamina or upper dermis. Bound IgG was detected in all seven cases. Bound C3 was detected in four of the seven cases. Both of these globulins were localized exclusively in the nondesmosomal and desmosomal epidermal intercellular cement substance region, apparently in the same fashion. It was suggested immunoelectronmicroscopically that not only IgG, but also the complement system might be involved in the formation of the skin lesion in pemphigus.
ORGAN CULTURE OF ADULT HUMAN SKIN; EFFECT OF CULTURE TEMPERATURE
Authors: Yasuno Hirokazu , Sotomatsu Shigetaro , Maeda Motoaki , Sato Michiko , Nishimura Akifumi , Matsubara Motoo 
Published: April 2015

ABSTRACTIn the organ culture of adult human skin, long‐term preservation of cultured epidermis was obtained when the culture temperature was shifted from 37°C to 32°C. The epidermal cell kinetics were compared for both culture temperatures using the findings of mitotic rate, mitotic distribution and autoradiographic labelling index with tritiated‐thymidine (3H‐TdR). As a result, it appeared that a lowered culture temperature controlled the cell cycle in vitro to maintain long‐term, active epidermal proliferation.
QUANTITATIVE DETERMINATION OF 5‐S‐CYSTEINYLDOPA, DOPA AND DOPAMINE IN THE URINE BY MEANS OF HIGH‐PERFORMANCE LIQUID CHROMATOGRAPHY
Authors: Morishima Takafumi , Saito Mariko , Hanawa Shigeru 
Published: April 2015

ABSTRACTThe levels of 5‐S‐cysteinyldopa (5‐SCD), 3,4‐dihydroxy‐phenylalanine (DOPA), and dopamine (DA) in the urine were determined by means of high‐performance liquid chromatography (HPLC) and fluorometry. There was a definite correlation between the data obtained by means of HPLC and those by fluorometry, suggesting that both methods are favorable for determining the levels of 5‐SCD, DOPA, and DA in the urine. However, HPLC is more useful than fluorometry for the following reasons: HPLC is easy for clinical practitioners to use; each substance shows good recovery; the values of 5‐SCD, DOPA, and DA can be determined in a single chromatographic run.
A FATAL CASE OF JUNCTIONAL EPIDERMOLYSIS BULLOSA (HERLITZ‐PEARSON)
Authors: Hiejima Mutsusuke , Inoue Shouhei , Ogata Katsumi 
Published: April 2015

ABSTRACTClinical findings, therapeutic responses and autopsy findings of a case of junctional epidermolysis bullosa were reported. A low serum zinc level was corrected by oral zinc sulphate with little improvement in skin lesions. Early diagnosis and genetle nursing were stressed.
ERYTHEMA DYSCHROMICUM PERSTANS
Authors: Inoue Shouhei , Kikuchi Ichiro , Ishii Yoshimitsu , Idemori Masahiro 
Published: April 2015

ABSTRACTErythema dyschromicum perstans (EDP) is a peculiar pigmented condition of unknown etiology, resistant to any treatment (1–3). We report a typical case of EDP and discuss its differential diagnosis.
THE EFFECTS OF db‐cAMP AND RELATED COMPOUNDS ON THE OUTGROWING EPIDERMIS IN VITRO
Authors: Aoyagi Takashi , Kamigaki Katsuko , Iizuka Hajime , Miura Yusho 
Published: April 2015

ABSTRACTExplant cultures of domestic pig skin were used to study the effects of db‐cAMP and related compounds on epidermal outgrowth and mitotic index in the outgrowing epidermis. Db‐cAMP and related compounds which elevated intracellular concentrations of cyclic AMP had inhibitory effects on epidermal outgrowth and mitotic index. Treatment with db‐cAMP in an early “migratory” phase revealed that db‐cAMP inhibited the migratory activities of epidermis in culture.
SCANNING ELECTRON MICROSCOPIC STUDIES OF DERMAL SKIN AND CONNECTIVE TISSUE DISORDERS
Authors: Hoshino Kumiko , Ohashi Masaru 
Published: April 2015

ABSTRACTBy using scanning electron microscopy (SEM), three dimensional structures of the matrixes and fibrous components in human dermal skin, scleromyxedema, systemic lupus erythematodes (SLE), progresive systemic sclerosis (PSS) and amyloidosis cutis were observed. SEM pictures were compared with those from conventional transmission electron microscopy and histochemistry. In human dermal skin and scleromyxedema, the matrixes were not fixed in glutaraldehyde and osmic acid. FAC fixation was employed in these specimens. After fixing specimens, streptomyces hyaluronidase digestion was made and examined by the SEM. In human dermis and scleromyxedema, hyarulonic acid occurred between collagen and elastic fibers.In systemic lupus erythematodes and progresive systemic sclerosis, specimens were fixed in glutaraldehyde and osmic acid, and examined in the same way. In SLE, collagen fibers were dissociated and the normal wavy pattern was lost. In PSS, abnormally increased branching fibers were observed. In amyloidosis cutis, amyloid fibrils were not observed by conventional SEM. Specimens were dehydrated in a critical point dryer and examined by the field emission scanning microscope. Amyloid fibrils were interwoven in a felt‐like fashion.