bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Osteophyte in the Tibial Plateau Is a Risk Factor for Allograft Extrusion After Meniscus Allograft Transplantation
Authors: Jeon Byeongsam , Kim Jong-Min , Kim Jong-Min , Lee Chang-Rack , Kim Kyung-Ah , Bin Seong-Il 
Published: February 2015

Background: Osteophytes can be observed on the tibial plateau during meniscus allograft transplantation (MAT). However, no studies to date have evaluated the effect of these osteophytes on meniscus allograft extrusion. Hypothesis: Osteophyte excision in the tibial plateau could reduce extrusion of the transplanted meniscus and improve short-term clinical outcomes with meniscus allograft transplantation. Study Design: Cohort study; Level of evidence, 3. Methods: Between October 2004 and July 2012, a total of 323 patients underwent MAT at a single institution. Of these, 88 patients had a peripheral osteophyte in their tibial plateau, and they were enrolled in the study retrospectively. The mean age of the patients was 35.3 years (range, 15-56 years); there were 57 male and 31 female patients. Forty-four patients underwent osteophyte excision concomitantly with MAT and 44 patients underwent MAT only. The 2 groups showed no difference in terms of age, body mass index, time after meniscectomy, and preoperative knee scores. A medial meniscus allograft was transplanted in 13 cases (15%) and a lateral meniscus in 75 (85%). The absolute extrusion and relative percentage of extrusion were measured to evaluate allograft extrusion 12 months after MAT. The modified Lysholm scoring system and the Hospital for Special Surgery score at 2 years after MAT were used to evaluate clinical outcomes. Results: The mean absolute extrusions at 1 year postoperatively in the excision and nonexcision groups were 3.5 ± 1.5 and 5.5 ± 1.6 mm, respectively. The mean relative percentages of extrusion were 34.1% ± 15.9% and 54.7% ± 20.7%, respectively. The rates of allograft extrusion (>3 mm) were 28 of 44 (63.6%) and 41 of 44 (93.2%) in the excision and nonexcision groups, respectively. The intergroup differences in absolute extrusion, relative percentage of extrusion, and rate of allograft extrusion were statistically significant ( P < .001 for all 3 parameters). There were no significant differences in the clinical outcomes (modified Lysholm or Hospital of Special Surgery scores) at 2-year follow-up ( P < .762 and < .298, respectively). Conclusion: The excision of a peripheral osteophyte larger than 2 mm in the proximal tibial plateau was associated with less allograft extrusion after MAT.
Simulation of a Dynamic Theory of Reasoned Action
Authors: Boster Franklin J. , Shaw Allison Z. , Carpenter Christopher J. , Massi Lindsey Lisa L. 
Published: February 2015

Background The Theory of Reasoned Action (TRA) is invoked frequently when social science scholars examine messages, affect, cognition, and action. Nevertheless, the fact that the TRA is a cross-sectional model limits its utility as an explanatory mechanism for those who study relationships among these variables as they change over time. This essay addresses this limitation by developing three versions of a Dynamic Theory of Reasoned Action (DTRA). Method Simulations were conducted to examine the properties of these varying DTRA models. The extent of autoregression was varied in these simulations, and the subsequent effects on the size and stability of the model parameters, the fit of the cross-sectional TRA, and the distributional properties of the variables that comprise the model were assessed. Results Results indicate that in the absence of an external shock (such as a persuasive message), these models reach equilibrium, and that trials to equilibrium increase as the autoregression parameters increase. The TRA fits perfectly at equilibrium, but may fail when the system is not in equilibrium, even when the DTRA fits perfectly. Finally, although starting with seed distributions closely approximating normality, distributional properties depart decidedly from normality over trials. Conclusion Implications for the fit of cross-sectional causal models and the meaning of cross-sectional associations are discussed.
Maintenance of Reduction With Suture Button Fixation Devices for Ankle Syndesmosis Repair
Authors: Peterson Kyle S. , Chapman W. Drew , Hyer Christopher F. , Berlet Gregory C. 
Published: February 2015

Background: Malreduction of the syndesmosis can lead to increased peak pressures and subsequent arthritis. The purpose of this study was to evaluate the initial syndesmotic reduction and radiographic maintenance when using a knotless suture button fixation device for treatment of syndesmotic injury. Methods: A retrospective chart and radiographic review was performed to identify patients who underwent open reduction internal fixation of ankle syndesmosis ruptures treated with a knotless, suture button fixation system. Radiographic measurements included medial clear space, tibiofibular overlap, tibiofibular clear space, and the distance between buttons. Fifty-six patients underwent repair of an ankle fracture with syndesmotic rupture over a 3-year period, with a mean follow-up of 160.9 days. Results: The tibiofibular clear space and tibiofibular overlap significantly improved from pre- to first postoperative, but also demonstrated some loss of fixation at final follow-up ( P < .001). The distance between the buttons increased on average 1.1 mm from immediate postoperative to final follow-up, demonstrating some postoperative creep and loss of fixation in the system. A low complication rate and need for a revision operation was found in our patient cohort. Some loss of reduction did occur postoperatively, although this did not correlate to adverse patient outcomes. Conclusion: Syndesmotic stabilization, using a knotless suture button fixation device demonstrated adequate initial syndesmotic reduction, but also exhibited an increase in the tibiofibular clear space and tibiofibular overlap, relative to initial postfixation position, at short-term follow-up. Level of Evidence: Level IV, retrospective case series.
“Rights without Access”: The Political Context of Inequality in Health Care Coverage in the U.S. States
Authors: Zhu Ling , Clark Jennifer H. 
Published: February 2015

AbstractThe question of how the American political process shapes inequality remains unsettled. While recent studies break ground by linking inequality to political institutions, much of this work focuses on national-level income inequality. The literature is lacking in its examination of inequality in other issue areas at the subnational level. This research explores how partisanship in government affects subnational-level inequality in health care coverage in the context of racial diversity. Using a new Gini-coefficient measure of inequality in health insurance coverage, we find a negative relationship between the seat share of Democratic representatives and inequality in health care coverage but only in states with racially diverse populations. Moreover, Democratic-controlled state legislatures mitigate the negative impact of racial diversity on inequality in health care coverage. These results highlight the importance of examining the partisan foundation of health care inequality in the context of racial diversity.
JMML and RALD (Ras-associated autoimmune leukoproliferative disorder): common genetic etiology yet clinically distinct entities
Authors: Calvo Katherine R. , Price Susan , Braylan Raul C. , Oliveira Joao Bosco , Lenardo Michael , Fleisher Thomas A. , Rao V. Koneti 
Published: February 2015

AbstractRas-associated autoimmune leukoproliferative disorder (RALD) is a chronic, nonmalignant condition that presents with persistent monocytosis and is often associated with leukocytosis, lymphoproliferation, and autoimmune phenomena. RALD has clinical and laboratory features that overlap with those of juvenile myelomonocytic leukemia (JMML) and chronic myelomonocytic leukemia (CMML), including identical somatic mutations in KRAS or NRAS genes noted in peripheral blood mononuclear cells. Long-term follow-up of these patients suggests that RALD has an indolent clinical course whereas JMML is fatal if left untreated. Immunophenotyping peripheral blood from RALD patients shows characteristic circulating activated monocytes and polyclonal CD10+ B cells. Distinguishing RALD from JMML and CMML has implications for clinical care and prognosis.
Black earths from Veneto and Piedmont (Northern Italy): origin, composition and potential use in different painting techniques
Authors: Cavallo Giovanni , Gianoli Barioni Karin 
Published: February 2015

Abstract
Terminology used to define black earths is general, vague and unclear with regard to the correspondence between the name of the pigment used in different epochs and its specific mineralogical and chemical composition. Furthermore, no distinction is reported in distinguishing organic and inorganic sources. Here, French, Spanish, German and Italian treatises and modern and contemporary literature have been consulted to understanding the use of this uncommon black pigment in different pictorial techniques. Polarizing Light Microscopy (PLM), X-Ray Diffraction (XRD) and X-Ray Fluorescence (XRF) analytical techniques are used to characterize both the raw materials collected in Veneto and Piedmont (Italy) and the black earths available on Italian and German markets. Results indicate that the studied materials are clay minerals rich compounds, in which the colouring fraction is due to the presence of carbonaceous matter and amorphous iron oxides. Depending on the microstructure, black shale and black chalk were identified. The properties of these materials when used in a fresco and a secco techniques are generally very good, as reported in the written sources, even if fading is observed when replicas were exposed in outdoor environment.
STAT5 phosphorylation in T cell subsets from septic patients in response to recombinant human interleukin-7: a pilot study
Authors: Demaret Julie , Dupont Guillaume , Venet Fabienne , Friggeri Arnaud , Lepape Alain , Rimmele´ Thomas , Morel Je´ro∘me , Monneret Guillaume 
Published: February 2015

Abstract
Septic shock is characterized by lymphocyte alterations associated with increased risk of nosocomial infections and mortality. IL-7, a cytokine required for T cell survival, is thought as a novel therapy for septic patients with severe lymphopenia. We assessed CD4+ lymphocyte responsiveness to rhIL-7 in septic shock patients ex vivo. Thirteen septic shock patients and 10 controls were included. The MFI of pSTAT5, a key signaling molecule for IL-7, was measured by flow cytometry in CD4+FOXP3− (Teffs) and CD4+FOXP3+ (Tregs) lymphocytes after whole-blood incubation with increasing doses of rhIL-7. The basal level of pSTAT5 in nonstimulated T cells was higher in patients. However, the maximal activation level in response to the highest doses of rhIL-7 was similar in both groups. Importantly, low doses of rhIL-7 preferentially activated Teff versus Treg in patients and nonsurvivors tended to present with decreased pSTAT5 expression. This pilot study is the first to highlight, in septic patients, the interest of pSTAT5 measurement in whole blood for the monitoring of rhIL-7 therapy. Such a method could represent an innovative, biologic tool for monitoring leukocyte pharmacological responses to biotherapies in daily clinical practice in other clinical contexts.
Final Report of the Intergroup Randomized Study of Combined Androgen-Deprivation Therapy Plus Radiotherapy Versus Androgen-Deprivation Therapy Alone in Locally Advanced Prostate Cancer
Authors: Mason Malcolm D. , Parulekar Wendy R. , Sydes Matthew R. , Brundage Michael , Kirkbride Peter , Gospodarowicz Mary , Cowan Richard , Kostashuk Edmund C. , Anderson John , Swanson Gregory , Parmar Mahesh K.B. , Hayter Charles , Jovic Gordana , Hiltz Andrea , Hetherington John , Sathya Jinka , Barber James B.P. , McKenzie Michael , El-Sharkawi Salah , Souhami Luis , Hardman P.D. John , Chen Bingshu E. , Warde Padraig 
Published: February 2015

PurposeWe have previously reported that radiotherapy (RT) added to androgen-deprivation therapy (ADT) improves survival in men with locally advanced prostate cancer. Here, we report the prespecified final analysis of this randomized trial.Patients and MethodsNCIC Clinical Trials Group PR.3/Medical Research Council PR07/Intergroup T94-0110 was a randomized controlled trial of patients with locally advanced prostate cancer. Patients with T3-4, N0/Nx, M0 prostate cancer or T1-2 disease with either prostate-specific antigen (PSA) of more than 40 μg/L or PSA of 20 to 40 μg/L plus Gleason score of 8 to 10 were randomly assigned to lifelong ADT alone or to ADT+RT. The RT dose was 64 to 69 Gy in 35 to 39 fractions to the prostate and pelvis or prostate alone. Overall survival was compared using a log-rank test stratified for prespecified variables.ResultsOne thousand two hundred five patients were randomly assigned between 1995 and 2005, 602 to ADT alone and 603 to ADT+RT. At a median follow-up time of 8 years, 465 patients had died, including 199 patients from prostate cancer. Overall survival was significantly improved in the patients allocated to ADT+RT (hazard ratio [HR], 0.70; 95% CI, 0.57 to 0.85; P < .001). Deaths from prostate cancer were significantly reduced by the addition of RT to ADT (HR, 0.46; 95% CI, 0.34 to 0.61; P < .001). Patients on ADT+RT reported a higher frequency of adverse events related to bowel toxicity, but only two of 589 patients had grade 3 or greater diarrhea at 24 months after RT.ConclusionThis analysis demonstrates that the previously reported benefit in survival is maintained at a median follow-up of 8 years and firmly establishes the role of RT in the treatment of men with locally advanced prostate cancer.
Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL
Authors: Burgoyne Thomas , O'Connor Marie N. , Seabra Miguel C. , Cutler Daniel F. , Futter Clare E. 
Published: February 2015

ABSTRACT
Analysis of melanosome biogenesis in the retinal pigment epithelium (RPE) is challenging because it occurs predominantly in a short embryonic time window. Here, we show that the zebrafish provides an ideal model system for studying this process because in the RPE the timing of melanosome biogenesis facilitates molecular manipulation using morpholinos. Morpholino-mediated knockdown of OA1 (also known as GPR143), mutations in the human homologue of which cause the most common form of human ocular albinism, induces a major reduction in melanosome number, recapitulating a key feature of the mammalian disease where reduced melanosome numbers precede macromelanosome formation. We further show that PMEL, a key component of mammalian melanosome biogenesis, is required for the generation of cylindrical melanosomes in zebrafish, which in turn is required for melanosome movement into the apical processes and maintenance of photoreceptor integrity. Spherical and cylindrical melanosomes containing similar melanin volumes co-exist in the cell body but only cylindrical melanosomes enter the apical processes. Taken together, our findings indicate that melanosome number and shape are independently regulated and that melanosome shape controls a function in the RPE that depends on localisation in the apical processes.
Highly Efficient Adsorption of Cr(VI) by Sakura Leaves from Aqueous Solution
Authors: Qi Wenfang , Wang Yue , Ji Min , Zhao Yingxin , Zhang Zhenya 
Published: February 2015

Abstract
A forestry waste, natural Sakura leaves (SL), was applied to remove Cr(VI) from aqueous solution. SL exhibited a highly effective adsorption performance at optimum pH 1.0. The presence of Cr(III) in equilibrium solution revealed that chemical redox reaction occurred. The results showed that the removal was successfully fitted to the Langmuir model (R2 &gt; 0.99). The theoretical maximum adsorption capacity of Cr(VI) was 148.12 mg g−1 in static adsorption, which was much higher than similar materials. The study provides a new way to reutilize the SL and indicates a strong potential for waste recycling.
Rapid and Selective Luminescence Response to Aromatic Thiols with a Simple Mononuclear Iridium(III) Complex
Authors: Ni Shitan , Mu Wensheng , Chao Duobin 
Published: February 2015

Abstract
A mononuclear cyclometalated iridium(III) complex 1 exhibited rapid and selective luminescence response to aromatic thiols. The phenomenon could be observed in solution or with test paper. The process has been studied through UV–vis spectra, photoluminescence spectra, HR-MS and 1H NMR spectroscopy. It is believed that complex 1 could react with aromatic thiols to produce strongly luminescent complexes in the solid state.
Privacy and Marketing Externalities: Evidence from Do Not Call
Authors: Goh Khim-Yong , Hui Kai-Lung , Png Ivan P. L. 
Published: February 2015

If not well targeted, advertising and direct marketing inflict nuisance and inconvenience on consumers. Theoretical analyses predict that consumer actions to avoid advertising impose externalities on other consumers. We investigate the extent of such externalities in the context of the U.S. Do Not Call (DNC) registry by exploiting the exogenous timing of the enforcement of the registry. Supported by multiple robustness tests, and validation and falsification exercises, we conclude that consumer DNC registrations imposed externalities on other consumers. An increase in the first wave of registrations by 1% was associated with a 3.1% increase in subsequent registrations. This effect was stronger in larger and more educationally or racially heterogeneous markets. The externality was possibly due to unregistered consumers being more receptive to telemarketing and telemarketers increasing calls to them. Our results suggest that managers should facilitate consumer opt-out, especially in larger and more educationally or racially heterogeneous markets. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2014.2051 . This paper was accepted by J. Miguel Villas-Boas, marketing.
Novel Schiff base amino acid as corrosion inhibitors for carbon steel in CO2-saturated 3.5% NaCl solution: experimental and computational study
Authors: Abd El-Lateef Hany M. , Ismael Mohamed , Mohamed Ibrahim M.A. 
Published: February 2015

AbstractThe corrosion inhibition and adsorption behavior of some novel Schiff bases based on amino acids on carbon steel in CO2-saturated 3.5% NaCl solution at 50°C was investigated using gravimetric, potentiodynamic polarization, linear polarization resistance corrosion rate, and scanning electron microscope (SEM)/energy-dispersive X-ray spectroscopy analysis (EDAX) techniques. Results show that the inhibition efficiency increases when the inhibitor concentration increases. Potentiodynamic polarization curves reveal that the used Schiff bases are mixed-type inhibitors. Experimental data indicate that these Schiff base inhibitors adsorb at the carbon steel/solution interface according the Langmuir adsorption isotherm. SEM/EDAX was used to examine the surface morphology of carbon steel samples in the absence and presence of the inhibitors. Quantum chemical calculations were further applied to explain the experimental results.
Improved method based on dual-energy X-ray absorptiometry for nondestructive evaluation of solid wood moisture content
Authors: Tanaka Takashi 
Published: February 2015

Abstract
An accurate, rapid, and convenient method is presented for moisture content (MC) determination of solid wood based on dual-energy X-ray absorptiometry (DXA). Poly(methyl methacrylate)-equivalent thicknesses (PMMA-EThs) of sugi (Cryptomeria japonica D. Don) wood blocks and pure water were measured by means of a wide range of X-ray tube voltages (20–100 kV). The ratio of the PMMA-ETh of pure water to that of wood decreased as X-ray tube voltage was increased, suggesting that an appropriate pair of tube voltages for DXA is 20 and 100 kV. According to this result, X-ray images of 30 wood samples were taken at 20- and 100-kV tube voltages, and their average PMMA-Eths from both images was determined. There was a strong negative correlation between the wet-basis MC of the wood sample and the ratio of its PMMA-Eth at 100 kV to that at 20 kV. A regression equation was developed for estimating the dry-basis MC of wood samples from their PMMA-ETh ratios. The standard error of estimate was 2.2%, which is better than those determined for electric moisture meters. This approach may lead to the development of a practical, nondestructive moisture meter for wood.
In vitro assessment of anticholinesterase and NADH oxidase inhibitory activities of an edible fern, Diplazium esculentum
Authors: Roy Subhrajyoti , Dutta Somit , Chaudhuri Tapas Kumar 
Published: February 2015

Abstract

Background:
Diplazium esculentum is the most commonly consumed edible fern throughout Asia and Oceania. Several studies have been performed so far to determine different functional properties of this plant, but there have been no reports on the anticholinesterase and nicotinamide adenine dinucleotide (NADH) oxidase inhibitory activities of this plant. Therefore, the present study was conducted to determine the anticholinesterase and NADH oxidase inhibitory activities of 70% methanolic extract of D. esculentum.

Methods: The D. esculentum extract was investigated for its acetylcholinesterase and NADH oxidase inhibitory activities as well as its free radical scavenging and total antioxidant activities in the linoleic acid system. The free radical scavenging activity of the extract was determined by the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) method. The total antioxidant activity of the extract was evaluated by ferric thiocyanate (FTC) and thiobarbituric acid (TBA) methods.

Results: The D. esculentum extract inhibited acetylcholinesterase and NADH oxidase in a dose-dependent manner, with IC50 values of 272.97±19.38 and 265.81±21.20 μg/mL, respectively. The extract also showed a potent DPPH radical scavenging activity with an IC50 value of 402.88±12.70 μg/mL. Moreover, the extract showed 27.41% and 33.22% of total antioxidant activities determined by FTC and TBA methods, respectively.

Conclusions: Results indicated that 70% methanolic extract of D. esculentum effectively inhibited the enzymes acetylcholinesterase and NADH oxidase and acted as a potent antioxidant and free radical scavenger. These in vitro assays indicate that this plant extract is a significant source of natural antioxidants, which may be helpful in preventing the progression of various neurodegenerative disorders associated with oxidative stress.
Investigation of oxidative phosphorylation in continuous cultures.
A non-equilibrium thermodynamic approach to energy transduction for
Escherichia coli in aerobic condition
Authors: Ghafuri Mohazabeh , Nosrati Mohsen , Hosseinkhani Saman 
Published: February 2015

Abstract
Adenosine triphosphate (ATP) production in living cells is very important.
Different researches have shown that in terms of mathematical modeling, the
domain of these investigations is essentially restricted. Recently the
thermodynamic models have been suggested for calculation of the efficiency
of oxidative phosphorylation process and rate of energy loss in animal cells
using chemiosmotic theory and non-equilibrium thermodynamics equations.
In our previous work, we developed a mathematical model for mitochondria
of animal cells. In this research, according to similarities between
oxidative phosphorylation process in microorganisms and animal cells,
Golfar's model was developed to predict the non-equilibrium thermodynamic
behavior of the oxidative phosphorylation process for bacteria in aerobic
condition. With this model the rate of energy loss, P/O ratio, and
efficiency of oxidative phosphorylation were calculated for Escherichia coli in aerobic
condition. The results then were compared with experimental data given by
other authors. The thermodynamic model had an acceptable agreement with the
experimental data.