bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Potent, Selective and Cell‐Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)
Authors: Kaniskan H. Ümit , Szewczyk Magdalena M. , Yu Zhengtian , Eram Mohammad S. , Yang Xiaobao , Schmidt Keith , Luo Xiao , Dai Miao , He Feng , Zang Irene , Lin Ying , Kennedy Steven , Li Fengling , Dobrovetsky Elena , Dong Aiping , Smil David , Min Sun‐Joon , Landon Melissa , Lin‐Jones Jennifer , Huang Xi‐Ping , Roth Bryan L. , Schapira Matthieu , Atadja Peter , Barsyte‐Lovejoy Dalia , Arrowsmith Cheryl H. , Brown Peter J. , Zhao Kehao , Jin Jian , Vedadi Masoud 
Published: February 2015

AbstractPRMT3 catalyzes the asymmetric dimethylation of arginine residues of various proteins. It is essential for maturation of ribosomes, may have a role in lipogenesis, and is implicated in several diseases. A potent, selective, and cell‐active PRMT3 inhibitor would be a valuable tool for further investigating PRMT3 biology. Here we report the discovery of the first PRMT3 chemical probe, SGC707, by structure‐based optimization of the allosteric PRMT3 inhibitors we reported previously, and thorough characterization of this probe in biochemical, biophysical, and cellular assays. SGC707 is a potent PRMT3 inhibitor (IC50=31±2 nM, KD=53±2 nM) with outstanding selectivity (selective against 31 other methyltransferases and more than 250 non‐epigenetic targets). The mechanism of action studies and crystal structure of the PRMT3‐SGC707 complex confirm the allosteric inhibition mode. Importantly, SGC707 engages PRMT3 and potently inhibits its methyltransferase activity in cells. It is also bioavailable and suitable for animal studies. This well‐characterized chemical probe is an excellent tool to further study the role of PRMT3 in health and disease.
Redox Tuning of a Direct Asymmetric Aldol Reaction
Authors: Zhang Qiying , Cui Xiuling , Zhang Long , Luo Sanzhong , Wang Hui , Wu Yangjie 
Published: February 2015

AbstractPresented herein is a redox tuning strategy for asymmetric aminocatalysis with a designed chiral ferrocenophane. Under redox control, the ferrocenophane catalyst efficiently catalyzes the asymmetric aldol reaction at room temperature with excellent yield and good stereoselectivity. Moreover, the redox‐active ferrocene moiety also served as phase‐tag to facilitate catalyst recovery and reuse. The catalyst can be reused for five cycles without much loss of activity. Ferrocenium of the oxidized ferrocenophane was proposed to serve as Lewis acidic site, thus accounting for the stereo control.
A Concise Flow Synthesis of Efavirenz
Authors: Correia Camille A. , Gilmore Kerry , McQuade D. Tyler , Seeberger Peter H. 
Published: February 2015

AbstractEfavirenz is an essential medicine for the treatment of HIV, which is still inaccessible to millions of people worldwide. A novel, semi‐continuous process provides rac‐Efavirenz with an overall yield of 45 %. This streamlined proof‐of‐principle synthesis relies on the efficient copper‐catalyzed formation of an aryl isocyanate and a subsequent intramolecular cyclization to install the carbamate core of Efavirenz in one step. The three‐step method represents the shortest synthesis of this life‐saving drug to date.
Robust Reliable H∞ Control for Discrete‐Time Systems with Actuator Delays
Authors: Sakthivel Rathinasamy , Sundareswari Krishnan , Mathiyalagan Kalidass , Arunkumar Arumugham , Anthoni Selvaraj Marshal 
Published: February 2015

AbstractThis article focuses on the robust state feedback reliable H∞ control problem for discrete‐time systems. Discrete‐time systems with time‐varying delayed control input are formulated. Based on the Lyapunov–Krasovskii method and linear matrix inequality (LMI) approach, delay‐dependent sufficient conditions are developed for synthesizing the state feedback controller for an uncertain discrete‐time system. The parameter uncertainty is assumed to be norm bounded. A design scheme for the state feedback reliable H∞ controller is proposed in terms of LMIs, which can guarantee the global asymptotic stability and the minimum disturbance attenuation level. Finally, numerical examples are provided to illustrate the effectiveness and reduced conservatism of the proposed methods.
Prevalence of birth defects among American‐Indian births in California, 1983‐2010
Authors: Aggarwal Deepa , Warmerdam Barbara , Wyatt Katrina , Ahmad Shabbir , Shaw Gary M. 
Published: February 2015

BackgroundApproximately 6.3 million live births and fetal deaths occurred during the ascertainment period in the California Birth Defects Monitoring Program registry. American‐Indian and non‐Hispanic white women delivered 40,268 and 2,044,118 births, respectively. While much information has been published about non‐Hispanic white infants, little is known regarding the risks of birth defects among infants born to American‐Indian women.MethodsThis study used data from the California Birth Defects Monitoring Program to explore risks of selected birth defects in offspring of American‐Indian relative to non‐Hispanic white women in California. The study population included all live births and fetal deaths 20 weeks or greater from 1983 to 2010. Prevalence ratios and corresponding 95% confidence intervals (CI) were computed using Poisson regression for 51 groupings of birth defects.ResultsPrevalence ratios were estimated for 51 groupings of birth defects. Of the 51, nine had statistically precise results ranging from 0.78 to 1.85. The eight groups with elevated risks for American‐Indian births were reduction deformities of brain, anomalies of anterior segments, specified anomalies of ear, ostium secundum type atrial septal defect, specified anomalies of heart, anomalies of the aorta, anomalies of great veins, and cleft lip with cleft palate.ConclusionOur results suggest that American‐Indian women having babies in California may be at higher risk for eight birth defect phenotypes compared with non‐Hispanic whites. Further research is needed to determine whether these risks are observed among other populations of American‐Indian women or when adjusted for potential covariates. Birth Defects Research (Part A) 103:105–110, 2015 © 2015 Wiley Periodicals, Inc.
Second‐derivative synchronous spectrofluorimetric determination of nebivolol hydrochloride and amlodipine besylate in their combined dosage form
Authors: Ibrahim F. , El‐Enany N. , Shalan SH , Abo Shabana R. A. 
Published: February 2015

AbstractA rapid, simple, accurate and highly sensitive spectrofluorimetric method was developed for the simultaneous analysis of nebivolol hydrochloride (NEB) and amlodipine besylate (AML). The method was based on measuring the synchronous fluorescence intensity of the drugs at Δλ = 40 nm in methanol. Various experimental parameters affecting the synchronous fluorescence of the studied drugs were carefully studied and optimized. The calibration plots were rectilinear over concentration ranges of 0.05–1.5 µg/mL and 0.5–10 µg/mL for NEB and AML with limits of detection (LOD) of 0.010 and 0.051 µg/mL and limits of quantitation (LOQ) of 0.031 and 0.156, respectively. The peak amplitudes (2D) of the second derivative synchronous fluorimetry (SDSF) were estimated at 282 nm for NEB and at 393 nm for AML. Good linearity was obtained over the concentration ranges. The proposed method was successfully applied to the determination of the studied compounds in laboratory‐prepared mixtures, commercial single and laboratory‐prepared tablets. The results were in good agreement with those obtained using the comparison method. The mean percent recoveries were found to be 100.12 ± 0.77 and 99.91 ± 0.77 for NEB and AML, respectively. Copyright © 2015 John Wiley & Sons, Ltd.
Association between serum level of ubiquinol and NT‐proBNP, a marker for chronic heart failure, in healthy elderly subjects
Authors: Onur Simone , Niklowitz Petra , Jacobs Gunnar , Lieb Wolfgang , Menke Thomas , Döring Frank 
Published: February 2015

AbstractUbiquinone and ubiquinol represent the oxidized and reduced forms of Coenzyme Q10 (CoQ10). CoQ10 is present in membranes of almost all human tissues and organs, with highest concentration in the heart. In patients with heart failure, serum levels of the N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) are an indicator of disease severity. Here, we investigated the relationship between serum levels of CoQ10 and NT‐proBNP in healthy volunteers of an elderly study population (mean age 52 years, n = 871). We found a negative association between serum levels of ubiquinol and NT‐proBNP (P < 0.001). Accordingly, the CoQ10 redox state (% oxidized form of CoQ10) is positively associated with serum NT‐proBNP level (P < 0.001). Compared to patients who survived a myocardial infarction (n = 21), healthy subjects have lower NT‐proBNP level (500.39 ± 631.28 pg/ml vs. 76.90 ± 120.27 pg/ml, P < 0.001), higher ubiquinol serum level (0.43 ± 0.19 µmol/L vs. 0.71 ± 0.32 µmol/L; P < 0.001), and a lower CoQ10 redox state (27.6 ± 13.8% vs. 17.6 ± 10.1%; P < 0.001). Interestingly, ubiquinol supplementation (150 mg/day; 14 day; n = 53) slightly reduces the expression of CLCN6, a gene related to NT‐proBNP level. In summary, higher serum levels of ubiquinol are associated with lower serum NT‐proBNP levels in healthy elderly subjects. However, to what extent a high serum level of ubiquinol is a protective factor for heart failure remains to be elucidated in prospective studies. © 2015 BioFactors, 41(1):35–43, 2015
Feasibility of implementing molecular‐guided therapy for the treatment of patients with relapsed or refractory neuroblastoma
Authors: Saulnier Sholler Giselle L. , Bond Jeffrey P. , Bergendahl Genevieve , Dutta Akshita , Dragon Julie , Neville Kathleen , Ferguson William , Roberts William , Eslin Don , Kraveka Jacqueline , Kaplan Joel , Mitchell Deanna , Parikh Nehal , Merchant Melinda , Ashikaga Takamaru , Hanna Gina , Lescault Pamela Jean , Siniard Ashley , Corneveaux Jason , Huentelman Matthew , Trent Jeffrey 
Published: February 2015

AbstractThe primary objective of the study was to evaluate the feasibility and safety of a process which would utilize genome‐wide expression data from tumor biopsies to support individualized treatment decisions. Current treatment options for recurrent neuroblastoma are limited and ineffective, with a survival rate of <10%. Molecular profiling may provide data which will enable the practitioner to select the most appropriate therapeutic option for individual patients, thus improving outcomes. Sixteen patients with neuroblastoma were enrolled of which fourteen were eligible for this study. Feasibility was defined as completion of tumor biopsy, pathological evaluation, RNA quality control, gene expression profiling, bioinformatics analysis, generation of a drug prediction report, molecular tumor board yielding a treatment plan, independent medical monitor review, and treatment initiation within a 21 day period. All eligible biopsies passed histopathology and RNA quality control. Expression profiling by microarray and RNA sequencing were mutually validated. The average time from biopsy to report generation was 5.9 days and from biopsy to initiation of treatment was 12.4 days. No serious adverse events were observed and all adverse events were expected. Clinical benefit was seen in 64% of patients as stabilization of disease for at least one cycle of therapy or partial response. The overall response rate was 7% and the progression free survival was 59 days. This study demonstrates the feasibility and safety of performing real‐time genomic profiling to guide treatment decision making for pediatric neuroblastoma patients.
Synthesis of Core–Shell Structured LiFe0.5Mn0.3Co0.2PO4@C with Remarkable Electrochemical Performance as the Cathode of a Lithium‐Ion Battery
Authors: Zhong Yanjun , Wu Zhenguo , Li Juntao , Xiang Wei , Guo Xiaodong , Zhong BenHe , Sun Shigang 
Published: February 2015

AbstractA carbon‐coated ternary olivine solid solution LiFe0.5Mn0.3Co0.2PO4 composite was synthesized by using a facile rheological phase reaction with stearic acid as the carbon source. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) characterization indicated that the core–shell structured LiFe0.5Mn0.3Co0.2PO4@C nanoplatelets are about 50 to 120 nm in size and have a quite uniform and complete carbon coating layer (4 nm thick). This uniform carbon layer not only improves the electronic conductivity of the materials, but also preserves the active material from corrosion by the electrolyte. The material was used as the electrode of a lithium‐ion battery and exhibited outstanding electrochemical performance, including good capacity and stable cycling behavior. It delivers a reversible discharge capacity of 146.7 mA h g−1 at 0.1 C. In addition, a discharge capacity of 110.5 mA h g−1 at 1 C was still maintained after 100 cycles with capacity retention of 90.6 %.
Osteochondroma in long‐term survivors of high‐risk neuroblastoma
Authors: Kushner Brian H. , Roberts Stephen S. , Friedman Danielle N. , Kuk Deborah , Ostrovnaya Irina , Modak Shakeel , Kramer Kim , Basu Ellen M. , Cheung Nai‐Kong V. 
Published: February 2015

BACKGROUNDOsteochondromas are benign bony protrusions that can be spontaneous or associated with radiotherapy (RT). Current treatment of high‐risk neuroblastoma includes dose‐intensive chemotherapy, local RT, an anti‐GD2 monoclonal antibody (MoAb), and isotretinoin. Late effects are emerging.METHODSThe authors examined osteochondromas in 362 patients who were aged <10 years when diagnosed with neuroblastoma, had received a MoAb plus isotretinoin since 2000, and had survived >24 months from the time of the first dose of the MoAb. The incidence rate of osteochondroma was determined using the competing risks approach, in which the primary event was osteochondroma calculated from the date of neuroblastoma diagnosis and the competing event was death without osteochondroma.RESULTSA total of 21 osteochondroma cases were found among 14 patients who were aged 5.7 to 15.3 years (median, 10.4 years) and 3.1 to 11.2 years (median, 8.2 years) from the time of neuroblastoma diagnosis. The cumulative incidence rate was 0.6% at 5 years and 4.9% at 10 years from the neuroblastoma diagnosis. Nine osteochondromas were revealed incidentally during assessments of neuroblastoma disease status or bone age. Thirteen osteochondromas were detected outside RT portals and had characteristics of spontaneous forms. Complications were limited to pain necessitating surgical resection in 3 patients, but follow‐up was short at 0.3 to 7.7 years (median, 3.5 years).CONCLUSIONSOsteochondromas in long‐term survivors of neuroblastoma should be expected because these benign growths can be related to RT and these patients undergo radiologic studies over years, are monitored for late toxicities through and beyond adolescence, and receive special attention (because of concerns about disease recurrence) if they develop a bony protuberance. A pathogenic role for chemotherapy, anti‐GD2 MoAbs, or isotretinoin remains speculative. Cancer 2015. © 2015 American Cancer Society. Cancer 2015;121:2090–2096. © 2015 American Cancer Society.
Finite element evaluation of the effect of fingertip geometry on contact pressure during flat contact
Authors: Harih Gregor , Tada Mitsunori 
Published: February 2015

SummarySeveral studies investigated the mechanical loads developing in the hands during the use of various products in order to enhance user's performance, increase satisfaction and lower the risk of acute and cumulative trauma disorders. Values of pressure discomfort (PDT) and pressure‐pain threshold (PPT) were, hence, provided. PDT and PPT may differ significantly for each subject and area of the hand because of psychological and physiological factors. A finite element study of the effect of fingertip anthropometry and anatomy geometry on mechanical loads developed during grasping is carried out in this research in order to assess physiological aspects behind variations of PDT and PPT existing between different subjects. It is found that the underlying anatomical structure and geometry (especially of the bone) significantly affect contact pressure distributions and pressure peak values. The largest difference in peak contact pressure between two different fingertips was in fact 27% for the same applied force. Furthermore, contact pressure distributions varied significantly between different subjects. The findings of this research provide novel insight into the phenomena of human grasping and the variation of contact pressure from subject to subject. Copyright © 2015 John Wiley & Sons, Ltd.
Drain Current in Poly(3‐hexylthiophene) Solutions during Film Formation: Correlations to Structural Changes
Authors: Park Min Sang , Aiyar Avishek , Park Jung Ok , Reichmanis Elsa , Srinivasarao Mohan 
Published: February 2015

AbstractConcurrent in situ Raman spectroscopic studies and drain current measurements were performed during drop‐cast poly(3‐hexylthiophene) (P3HT) film formation. Together, these techniques allow interrogation and elucidation of the evolution of P3HT structural changes and associated electrical characteristics as the solvent evaporates. Two observations are especially significant: i) solvent continued to be present in the developing thin‐film at the point where the drain current exhibited a sharp increase and ii) continued to be observed after crystallization of the polymer. The in situ studies provide vital insights into the polymer organization and chain alignment processes at the molecular and macroscopic scales. The results suggest that final conjugated polymer thin‐film morphology can be tailored for enhanced performance and desired electronic properties through quenching of the active polymer layer at a specified time during the solidification process.
Graphene Oxide Wrapping of Gold–Silica Core–Shell Nanohybrids for Photoacoustic Signal Generation and Bimodal Imaging
Authors: Sreejith Sivaramapanicker , Joseph James , Nguyen Kim Truc , Murukeshan Vadakke Matham , Lye Sun Woh , Zhao Yanli 
Published: February 2015

AbstractWe report the development of graphene oxide (GO) wrapped silica‐coated gold nanoparticles (GO‐AuNP@SiO2), which exhibit an unprecedented absorption enhancement in the visible region of the electromagnetic spectrum. GO coating on the core–shell nanohybrid enhances residual plasmonic absorption of the nanohybrid while maintaining its compact size. Finite‐difference time domain simulations show an electromagnetic field intensity enhancement owing to GO wrapping over three different gold cores with 10, 20 and 30 nm in diameter and uniform silica thickness of 30 nm. Bimodal imaging using fluorescent microbeads reveals an enhanced photoacoustic signal from GO‐AuNP@SiO2 in an integrated photoacoustic and fluorescence imaging setup. Present approach provides a fundamental platform for photoacoustic signal generation using plasmonic nanoparticles with low toxicity. This unique strategy opens up new avenues for enhancing photoacoustic signals and for combined fluorescence and photoacoustic imaging.
The influence of color on student emotion, heart rate, and performance in learning environments
Authors: AL‐Ayash Aseel , Kane Robert T. , Smith Dianne , Green‐Armytage Paul 
Published: February 2015

AbstractIn this study, six colors (vivid red, vivid blue, vivid yellow, pale red, pale blue, and pale yellow†) were manipulated in a simulated study environment to determine their effects on university students' learning performance, emotions, and heart rate. It was hypothesized that learning, physiological and emotional states would be affected by different colors in private study spaces. A total of 24 undergraduate and postgraduate students participated in this study. The dependent variables were reading task performance, emotional responses, and changes in heart rate. The results showed that, although participants assessed the situation as relaxed, calm, and pleasant in the pale color conditions, reading scores were significantly higher in the vivid color conditions. Heart rates were significantly affected by hue; they increased in the red and yellow conditions. In addition, the results suggested that, regardless of the degree of whiteness, the hue had a significant impact on participants' emotions; blue increased relaxation and calmness feelings of participants compared to the other colors. Implications of these findings and suggestions for further research are discussed. © 2015 Wiley Periodicals, Inc. Col Res Appl, 41, 196–205, 2016
Exploring the Electronic Structure of an Organic Semiconductor Based on a Compactly Fused Electron Donor–Acceptor Molecule
Authors: Alemany Pere , Canadell Enric , Geng Yan , Hauser Jürg , Macchi Piero , Krämer Karl , Decurtins Silvio , Liu Shi‐Xia 
Published: February 2015

AbstractA Mott‐type semiconductor based on a compactly fused and partially oxidized electron donor–acceptor (D–A) molecule was recently prepared and identified to exhibit a large room‐temperature conductivity of 2 S cm−1. In a marked contrast to the organic conductors characterized by relatively well decoupled and segregated uniform stacks of D and A moieties, the formally half‐oxidized tetrathiafulvalene donors of the actual compound are organized in columnar π stacks only, whereby the coplanar electron‐acceptor units, namely benzothiadiazole, are closely annulated along their ridges. Herein, we present a theoretical study that explores the electronic structure of this novel type of organic semiconductor. The highly symmetric‐solid state material behaves as a one‐dimensional electronic system with strong antiferromagnetic interactions (coupling constant>200 cm−1). The unique shape and local dipole of this redox‐active fused electron D–A molecule lays the basis for further investigations of the collective electronic structure, mainly in the function of different counterions embedded in the crystalline lattice.
Discharge Performance of Solid‐State Oxygen Shuttle Metal–Air Battery Using Ca‐Stabilized ZrO2 Electrolyte
Authors: Inoishi Atsushi , Kim Hack‐Ho , Sakai Takaaki , Ju Young‐Wan , Ida Shintaro , Ishihara Tatsumi 
Published: February 2015

AbstractThe effects of metal choice on the electrochemical performance of oxygen‐shuttle metal–air batteries with Ca‐stabilized ZrO2 (CSZ) as the electrolyte and various metals as the anodes were studied at 1073 K. The equilibrium oxygen partial pressure (P) in the anode chamber was governed by the metal used in the anode chamber. A lower‐P environment in the anode decreased the polarization resistance of the anode. The oxidation of oxide ions to oxygen in the anode is drastically enhanced by the n‐type conduction generated in the CSZ electrolyte when it is exposed to a reducing atmosphere. A high discharge potential and high capacity can be achieved in an oxygen‐shuttle battery with a Li or Mg anode because of the fast anode reaction compared to that of cells with a Zn, Fe, or Sn anode. However, only the mildly reducing metals (Zn, Si, Fe, and Sn) can potentially be used in rechargeable metal–air batteries because the transport number of the CSZ electrolyte must be unity during charge and discharge. Oxygen shuttle rechargeable batteries with Fe, and Sn electrodes are demonstrated.