bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multinational study of self‐compassion and human immunodeficiency virus‐related anxiety
Authors: Kemppainen J. , Johnson M.O. , Phillips J.C. , Sullivan K.M. , Corless I.B. , Reid P. , Iipinge S. , Chaiphibalsarisdi P. , Sefcik E. , Chen W.‐T. , Kirksey K. , Voss J. , Rivero‐Méndez M. , Tyer‐Viola L. , Dawson Rose C. , Webel A. , Nokes K. , Portillo C. , Holzemer W.L. , Eller L. , Nicholas P. , Wantland D. , Brion J. , Beamon E.R. 
Published: September 2013

AimThis study represents an initial effort at examining the association between the construct of self‐compassion and human immunodeficiency virus (HIV)‐related anxiety in a multinational population with HIV disease.BackgroundPrevious studies have found that self‐compassion is a powerful predictor of mental health, demonstrating positive and consistent linkages with various measures of affect, psychopathology and well‐being, including anxiety.MethodsCross‐sectional data from a multinational study conducted by the members of the International Nursing Network for HIV Research (n = 1986) were used. The diverse sample included participants from Canada, China, Namibia, the United States of America and the territory of Puerto Rico. Study measures included the anxiety subscale of the Symptom Checklist‐90 instrument, the Brief Version Self‐Compassion Inventory and a single item on anxiety from the Revised Sign and Symptom Checklist.FindingsStudy findings show that anxiety was significantly and inversely related to self‐compassion across participants in all countries. We examined gender differences in self‐compassion and anxiety, controlling for country. Levels of anxiety remained significantly and inversely related to self‐compassion for both males (P = 0.000) and females (P = 0.000). Levels of self‐compassion and anxiety varied across countries.ConclusionsSelf‐compassion is a robust construct with cross‐cultural relevance. A culturally based brief treatment approach aimed at increasing self‐compassion may lend itself to the development of a cost effective adjunct treatment in HIV disease, including the management of anxiety symptoms.
Comparison of the biomechanical properties of a ventral cervical intervertebral anchored fusion device with locking plate fixation applied to cadaveric canine cervical spines
Authors: Schöllhorn Bernhard , Bürki Alexander , Stahl Christina , Howard Judith , Forterre Franck 
Published: September 2013

AbstractObjectiveTo evaluate fixation properties of a new intervertebral anchored fusion device and compare these with ventral locking plate fixation.Study DesignIn vitrobiomechanical evaluation.AnimalsCadaveric canine C4–C7 cervical spines (n = 9).MethodsCervical spines were nondestructively loaded with pure moments in a nonconstraining testing apparatus to induce flexion/extension while angular motion was measured. Range of motion (ROM) and neutral zone (NZ) were calculated for (1) intact specimens, (2) specimens after discectomy and fixation with a purpose‐built intervertebral fusion cage with integrated ventral fixation, and (3) after removal of the device and fixation with a ventral locking plate.ResultsBoth fixation techniques resulted in a decrease in ROM and NZ (P < .001) compared with the intact segments. There were no significant differences between the anchored spacer and locking plate fixation.ConclusionAn anchored spacer appears to provide similar biomechanical stability to that of locking plate fixation.
USGS46 Greenland Ice Core Water – A New Isotopic Reference Material for δ2H and δ18O Measurements of Water
Authors: Coplen Tyler B. , Qi Haiping , Tarbox Lauren , Lorenz Jennifer , Buck Bryan 
Published: September 2013

Ice core from Greenland was melted, filtered, homogenised, loaded into glass ampoules, sealed, autoclaved to eliminate biological activity, and calibrated by dual‐inlet isotope‐ratio mass spectrometry. This isotopic reference material (RM), USGS46, is intended as one of two secondary isotopic reference waters for daily normalisation of stable hydrogen (δ2H) and stable oxygen (δ18O) isotopic analysis of water with a mass spectrometer or a laser absorption spectrometer. The measured δ2H and δ18O values of this reference water were −235.8 ± 0.7‰ and −29.80 ± 0.03‰, respectively, relative to VSMOW on scales normalised such that the δ2H and δ18O values of SLAP reference water are, respectively, −428 and −55.5‰. Each uncertainty is an estimated expanded uncertainty (U = 2uc) about the reference value that provides an interval that has about a 95‐percent probability of encompassing the true value. This reference water is available in cases containing 144 glass ampoules that are filled with either 4 ml or 5 ml of water per ampoule.
Development and psychometric testing of the online Adolescent Diabetes Needs Assessment Tool (ADNAT)
Authors: Cooper Helen , Spencer Joy , Lancaster Gillian A. , Titman Andrew , Johnson Mark , Wheeler Sara Louise , Lwin Rebekah 
Published: September 2013

AbstractAimTo report on the development and psychometric testing of the Adolescent Diabetes Needs Assessment Tool.BackgroundTheUKhas the fifth largest paediatric diabetes population in the world, but one of the poorest levels of diabetes control, highlighting the need for intervention development.DesignMixed methods following recommendations for questionnaire design and validation.MethodsA total of 171 young people (12–18 years) participated between 2008– 2011. Methods included item selection using secondary framework analysis, item review, pre‐testing, piloting and online transfer. Statistical tests assessed reliability using item‐total correlations, interitem consistency and test–retest reliability; and validity using blood glucose (HbA1c) levels and the Self‐Management of type 1 Diabetes in Adolescence questionnaire.ResultsThe Adolescent Diabetes Needs Assessment Tool consists of 117 questions divided between six domains of educational and psychosocial support needs. It combines reflective questioning with needs assessment to raise self‐awareness to support adolescent decision‐making in relation to diabetes self‐care. Thirty‐six of the questions provide self‐care and psychosocial health assessment scores. Face and content validity of the scoring items were all positively evaluated in terms of appropriateness and readability and tests for validity found significant correlations with Self‐Management of type 1 Diabetes in Adolescence and weak correlation with HbA1c, which compared favourably with Self‐Management of type 1 Diabetes in Adolescence, the only comparable (USA) tool. Item response analysis validated the use of simple additive scores.ConclusionsThe Adolescent Diabetes Needs Assessment Tool combines reflective learning with needs assessment to support patient‐centred clinical consultations.
Therapy targets in glioblastoma and cancer stem cells: lessons from haematopoietic neoplasms
Authors: Cruceru Maria Linda , Neagu Monica , Demoulin Jean‐Baptiste , Constantinescu Stefan N. 
Published: September 2013

AbstractDespite intense efforts to identify cancer‐initiating cells in malignant brain tumours, markers linked to the function of these cells have only very recently begun to be uncovered. The notion of cancer stem cell gained prominence, several molecules and signalling pathways becoming relevant for diagnosis and treatment. Whether a substantial fraction or only a tiny minority of cells in a tumor can initiate and perpetuate cancer, is still debated. The paradigm of cancer‐initiating stem cells has initially been developed with respect to blood cancers where chronic conditions such as myeloproliferative neoplasms are due to mutations acquired in a haematopoietic stem cell (HSC), which maintains the normal hierarchy to neoplastic haematopoiesis. In contrast, acute leukaemia transformation of such blood neoplasms appears to derive not only from HSCs but also from committed progenitors that cannot differentiate. This review will focus on putative novel therapy targets represented by markers described to define cancer stem/initiating cells in malignant gliomas, which have been called ‘leukaemia of the brain’, given their rapid migration and evolution. Parallels are drawn with other cancers, especially haematopoietic, given the similar rampant proliferation and treatment resistance of glioblastoma multiforme and secondary acute leukaemias. Genes associated with the malignant conditions and especially expressed in glioma cancer stem cells are intensively searched. Although many such molecules might only coincidentally be expressed in cancer‐initiating cells, some may function in the oncogenic process, and those would be the prime candidates for diagnostic and targeted therapy. For the latter, combination therapies are likely to be envisaged, given the robust and plastic signalling networks supporting malignant proliferation.
Diurnal variation of carbohydrate insulin ratio in adult type 1 diabetic patients treated with continuous subcutaneous insulin infusion
Authors: Nakamura Tomoaki , Hirota Yushi , Hashimoto Naoko , Matsuda Tomokazu , Takabe Michinori , Sakaguchi Kazuhiko , Ogawa Wataru , Seino Susumu 
Published: September 2013

AbstractTo estimate the carbohydrate‐to‐insulin ratio (CIR), a formula dividing a constant, usually 300–500, by the total daily dose (TDD) of insulin, is widely utilized. An appropriate CIR varies for each meal of the day, however. Here, we investigate diurnal variation of CIR in hospitalized Japanese type 1 diabetic patients treated with continuous subcutaneous insulin infusion. After optimization of the insulin dose, TDD and total basal insulin dose (TBD) were 34.9 ± 10.2 and 9.3 ± 2.8 units, respectively, with a percentage of TBD to TDD of 27.3 ± 6.0%. The products of CIR and TDD at breakfast, lunch and dinner were 311 ± 63, 530 ± 161, and 396 ± 63, respectively, suggesting that in the formula estimating CIR using TDD, the constant should vary for each meal of the day, and that 300, 500, and 400 are appropriate for breakfast, lunch, and dinner, respectively.
C‐reactive protein in psoriasis: a review of the literature
Authors: Beygi S. , Lajevardi V. , Abedini R. 
Published: September 2013

AbstractA great deal of research has addressed the elevation of C‐reactive protein (CRP) among psoriatic patients and the role of this marker in assessment of disease severity and progression. However, there are some discrepancies in this area. We sought to figure out the relationship between CRP values and disease severity as well as the changes in marker levels after treatment through an extensive literature review. Comparison between CRP levels in psoriatic patients and those in healthy or non‐psoriatic individuals was also another focus of this review. A thorough search in Pubmed and Embase was conducted for articles investigating different aspects of CRP measurement in patients with psoriasis. Overall, 32 articles were found to meet our inclusion criteria. Of 28 studies comparing the CRP values in psoriatic patients with those of controls, 24 found a statistically significant difference. In addition, 12 out of 16 papers examining the association between disease severity and CRP values noted significant results. With regard to CRP changes over the course of a treatment, all 15 studies addressing this issue revealed a significant decrease in marker levels. In conclusion, high CRP levels only for moderate and severe forms of disease might be inferred from the literature and there is no sufficient evidence suggesting a similar association for mild disease as well. Moreover, CRP may serve interchangeably with Psoriasis Area and Severity Index (PASI) as a measure of disease severity in the case of untreated psoriatic patients who do not have disease related arthritis. For other patients, however, a careful clinical examination and PASI calculation still remain the mainstay of severity assessment.
Overview of the use of dermoscopy in academic and non‐academic hospital centres in France: a nationwide survey
Authors: Breton A.L. , Amini‐Adle M. , Duru G. , Poulalhon N. , Dalle S. , Thomas L. 
Published: September 2013

AbstractBackgroundDermoscopy is acknowledged to improve the diagnostic accuracy of melanoma by several concordant meta‐analyses. However, the use of dermoscopy was not considered as a high level of evidence diagnostic tool by French Health Authorities. However, as shown in Australian, American and in our recent surveys, dermoscopy is used by most of dermatologists in private practice.ObjectivesTo analyse the use, beliefs, teaching given and research produced in dermoscopy in dermatology departments of French hospitals.MethodsA questionnaire about the use, available equipment, teaching activities and published research on dermoscopy was mailed to all chairmen of dermatology departments in French both academic and non‐academic hospitals.ResultsSeventy‐six of 110 mailed questionnaires were returned. The majority of centres claimed to use dermoscopy (97.5%), but it seemed heterogeneous among practitioners according to their age and position. The use of dermoscopy was four times higher in non‐academic centres (P = 0.015). Centres located in the south east of France were higher users comparing with others (P = 0.004). Earlier detection of melanoma was the most important advantage reported. Excessive training time was the most important reported disadvantage. Twenty‐five percent of centres had dedicated clinics for pigmented lesions. Few centres (14.5%) run formal dermoscopy training programs. Most centres (74.7%) declared a use of dermoscopy for the diagnosis of non‐tumoral diseases.ConclusionsThis is the first European study evaluating the use of dermoscopy among hospital. Despite a large use, dermoscopy‐dedicated teaching and research time appeared to be insufficient.
Confirmation of oxidative stress and fatty acid disturbances in two further Papillon–Lefèvre syndrome families with identification of a new mutation
Authors: Bullón P. , Morillo J.M. , Thakker N. , Veeramachaneni R. , Quiles J.L. , Ramírez‐Tortosa M.C. , Jaramillo R. , Battino M. 
Published: September 2013

AbstractBackgroundWe have previously reported oxidative and fatty acids disturbances in one Papillon–Lefèvre syndrome (PLS) family. This Mendelian condition characterized by palmar plantar keratosis and severe aggressive periodontitis, is caused by mutations in the cathepsin C (CTSC) gene. In this study, we have analysed two further unrelated PLS families to confirm this association.MethodsMutations were identified by direct sequencing of CTSC. Biochemical analyses were performed in probands and their relatives in order to determine plasma levels of vitamin E, CoQ10, lipid hydroperoxides (HP) and fatty acid patterns.ResultsPathogenic CTSC mutations were identified in both families including a new mutation (c504C>G). Both probands showed low levels of vitamin E and CoQ10, and high levels of lipid HP, and also very low levels of docohexaenoic acid.ConclusionsThe previously reported oxidative and fatty acids disturbances were confirmed as a feature of this condition in two further families. There are low levels of antioxidant markers and high levels of oxidative markers, in addition of low levels of some anti‐inflammatory fatty acids in persons suffering PLS and some of their relatives.
Ribose‐Induced Maillard Reaction as a Quality Index in Frozen Minced Chicken and Pork Meats
Authors: Tan Thuan‐Chew , Alkarkhi Abbas F.M. , Easa Azhar Mat 
Published: September 2013

AbstractMinced meats underwent denaturation, oxidation and aggregation during frozen storage, causing decrease in denaturation enthalpy, sulfhydryl contents and protein solubility, as well as increase in protein carbonyl and disulfide contents. These changes were more evident in samples stored at −4C than those stored at −20C, as reactions occurred at faster rates at higher temperature. The addition of ribose on thawed minced meats followed by heating at 95C initiated Maillard reaction browning. Browning index () was significantly higher (P < 0.05) in fresh minced meats than in frozen ones, decreased with storage time and were lower in minced meat stored at −4C than those stored at −20C. The biochemical changes in meat proteins during frozen storage reduced the availability of basic amino acids to take part in the Maillard reaction. Hence, could be used as freshness index in minced chicken and minced pork.Practical ApplicationsLong‐term frozen storage of meat causes degradative changes which leads to the loss of functionality, flavor, texture and organoleptic properties of the meat. Due to these losses, fresh meat is often perceived to be of a better quality and often valued at a higher market price compared to those of frozen meat. This study proposed an alternative, simpler, quicker and cheaper method to identify between fresh versus frozen/thawed meat. The proposed method was based on the Maillard reaction between proteins of meat and ribose, yielding brown pigments (melanoidins) that can be measured as absorbance and converted into a freshness index. It was demonstrated that the biochemical degradation during frozen storage reduces the availability of meat proteins to react with ribose, yielding lower freshness index as compared to those of fresh meat. Thus, freshness index could be used as a quality control method to ascertain meat freshness and to evaluate supplier's reliability.
Quality and Shelf Life of Fresh Chicken Breasts Subjected to Crust Freezing with and without Skin
Authors: Dawson Paul L. , Chaves Byron D. , Northcutt Julie K. , Han Invee Y. 
Published: September 2013

AbstractThe effect of crust freezing (20 min, −85C) on raw chicken breast quality, with or without skin, during aerobic, refrigerated storage for up to 18 days was assessed using the International Commission on Illumination color parameters L*, a* and b*; tenderness; total aerobic (aerobic plate counts [APC]) and yeasts/molds counts. Skin on had significantly higher L* values compared with skinless breasts (average 75 versus 55), whereas a* and b* remained relatively constant regardless of the presence or absence of skin, freezing or time. For a* and b*, values oscillated between −2.10–0.78 and 1.38–3.77, respectively. Shear energy varied for skinless samples but tended to remain constant throughout time for skin‐on breasts. APC increased over time, exceeding 8.0 log10 cfu/mL of rinse, between 6 and 12 days of storage. Crust freezing did not affect color or tenderness of raw chicken breasts, with or without skin, but also did not extend microbiological shelf life.Practical ApplicationsRaw poultry products are susceptible to spoilage and deterioration. Several freezing applications at the commercial level claim to improve quality attributes or extend shelf life of these products. Crust freezing, where the product is semi‐frozen only at superficial layers of tissue, is one such application. The current study found that crust freezing did not affect quality attributes of raw chicken breasts, with or without skin, but neither did it extend their shelf life under aerobic, refrigerated storage, based on aerobic plate count values. Although further investigation is needed, this research serves as the foundation for other studies to benefit the industry. Because crust freezing is widely accepted as a shelf life‐extending treatment, the results of this study imply that the freezing method, length of the crust freeze time, and the product type and form may influence the effectiveness of crust freezing for shelf life extension.
Angiotensin‐Converting Enzyme Inhibitors and Alzheimer's Disease Progression in Older Adults: Results from the Réseau sur la Maladie d'Alzheimer Français Cohort
Authors: Soto Maria E. , Abellan van Kan Gabor , Nourhashemi Fati , Gillette‐Guyonnet Sophie , Cesari Matteo , Cantet Christelle , Rolland Yves , Vellas Bruno 
Published: September 2013

ObjectivesTo assess whether angiotensin‐converting enzyme inhibitor (ACE‐I) treatment is associated with less cognitive decline in older adults with Alzheimer's disease (AD) than in those using other hypertensive or no drugs.DesignFour‐year prospective multicenter cohort study with a biannual assessment.SettingMemory clinics from 16 university hospitals in France.ParticipantsCommunity‐dwelling older adults with mild to moderate AD (N = 616).MeasurementsParticipants were stratified into four groups according to type and duration of antihypertensive drug treatment. Cognitive decline was assessed using the Mini‐Mental State Examination (MMSE). Linear mixed‐effects models were used to assess differences in decline in MMSE score between the four groups. Hypertension at each visit was included in the model.ResultsSixty‐one participants had used ACE‐Is continuously, 57 had used them intermittently, 189 had used other antihypertensive drugs, and 309 never used any antihypertensive drugs. Continuous ACE‐Is users had a 4‐year decline in MMSE of 6.4 ± 1.6 points (P < .001), intermittent ACE‐Is users of 7.9 ± 1.1 points (P < .001), continuous or intermittent users of other antihypertensive drugs of 8.8 ± 0.7 points (P < .001), and never‐users of 10.2 ± 0.6 points (P < .001). MMSE decline between the four groups was significantly different (adjusted P = .02). In subgroup analysis, the 118 (19.2%) participants who had continuously or intermittently used ACE‐Is had a significant difference in 4‐year MMSE decline from the 498 (80.8%) who had never used ACE‐Is (7.5 ± 0.9 vs 9.7 ± 0.4; P = .03).ConclusionThe use of ACE‐Is in older adults with AD is associated with a slower rate of cognitive decline independent of hypertension. Future research is needed to explore the role of ACE‐Is in long‐term AD progression.
Neurofibromatosis and fibrous dysplasia manifesting in the same patient: a rare case report
Authors: Sujatha Sampangi , Jatti Deepa 
Published: September 2013

AbstractNeurofibromatosis and fibrous dysplasia show the presence of café‐au‐lait spots, bone lesions, and endocrinopathies. There has been speculation whether neurofibromatosis and fibrous dysplasia are different manifestations of the same disease or if these conditions are in some way related. We provide a case of whether neurofibromatosis and fibrous dysplasia complicated by hyperparathyroidism and osteoporosis.
Early Predictive Value of Susceptibility Weighted Imaging (SWI) in Pediatric Hypoxic‐Ischemic Injury
Authors: Messina Steven A. , Poretti Andrea , Tekes Aylin , Robertson Courtney , Johnston Michael V. , Huisman Thierry A.G.M. 
Published: September 2013

ABSTRACTSusceptibility weighted imaging (SWI) provides information about the intravascular cerebral blood oxygenation level. Deoxyhemoglobin is increased in tissue with increased oxygen extraction fraction. Accordingly, the draining veins in hypoxic‐ischemic brain may reveal abnormally low SWI signal. We report on a boy with hypoxic‐ischemic injury (HII) after cardiac arrest and the ability of SWI to depict areas of HII by focusing on the venous cerebral drainage.