bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Intramuscular Hemangioma of the Back
Authors: Kim You Chan , Park Hyang Joon , Cinn Yong Woo 
Published: April 2015

AbstractIntramuscular hemangioma is an uncommon tumor that usually involves an extremity. They rarely occur after the age of 30. We report a case of an intramuscular hemangioma occurring on the back of a 39‐year‐old man. Histopathologically, the tumor consisted mainly of large vessels between the muscle fibers. Phleboliths were observed in some of the vessel walls.
Hair‐Discoloration of Japanese Elite Swimmers
Authors: Nanko Hiroko , Mutoh Yoshiteru , Atsumi Reiko , Kobayashi Youko , Ikeda Michiko , Yoshikawa Nobuko , Fukuda Satoru , Kawa Youko , Mizoguchi Masako 
Published: April 2015

AbstractTo understand hair‐discoloration in relation to swimming, we examined sixty‐seven elite swimmers of the Japan National Swimming Team and fifty‐four, age‐matched subjects as controls. The incidence of hair discoloration (61%) in the swimmers' group was significantly higher than that in controls (0%) (p<0.0001). Interestingly, surface damage of the nail plates coexisted in the swimmers with the scalp‐hair discoloration. The hairs picked from the eight swimmers and two age‐matched individuals as controls were examined by electron microscope (EM) and EM X‐ray microanalyzer. The swimmers' discolored, golden hair revealed complete disappearance of hair cuticle both by scanning EM (SEM) and transmission EM (TEM). The quantity of melanosomes in the cortex decreased, and their diameter was smaller than that of controls. In addition, irregularly shaped melanosomes with variable electron density and less electron‐dense melanosomes with white haloes were frequently observed in the swimmers' golden hair. The X‐ray elemental spectrograph by SEM revealed that the content of sulfur in all the swimmers' discoloured hair was lower than that in the normal controls and that the content of chlorine in the male swimmers' discoloured hair was higher than that in the female swimmers and the normal controls. The X‐ray elemental microanalysis by TEM focused on melanosomes in the cortex of the cross section and detected elemental chlorine in all swimmers' golden hairs. It did not detect any element in the control hairs. The 14C‐tyrosine uptake test of hairbulbs found no significant difference between the swimmers and the normal controls. These findings suggest that hair discoloration was mainly due to cuticle damage by friction with water. Hypochlorous acid in the swimming pool water can penetrate to the hair cortex through the cuticle. It can oxidize and degenerate melanosomes there.
Effects of Adjuvant Interferon‐alpha Low‐dose Therapy in Melanoma Patients on Serum Inhibin B
Authors: Karamfilov Theodor , Wollina Uwe , Hipler Uta‐Christina , Graefe Tim , Schreiber Gerhard 
Published: April 2015

AbstractBecause the primary aim of adjuvant therapy for melanoma is not curative, all the possible aspects of quality of life have to be considered. One aspect of increasing importance is fertility. The effect of adjuvant interferon α‐therapy for malignant melanoma on male fertility has not been systematically investigated. In the present study, twelve male patients with primary cutaneous melanoma (pT3, 4; N0; M0) who were taking adjuvant low‐dose interferon α2b (3 times 3 mio U/week) for one year were included. Inhibin B—an established marker of male fertility—was measured with an immunosorbent assay before and after one year of interferon α‐therapy to investigate whether this treatment has any influence on fertility. The results were compared with those from normal controls (n=40). The mean serum inhibin B concentration in melanoma patients before interferon therapy was 225.4 ± 112.5 pg/mL; after treatment the level was 229.6 ± 82.0 pg/mL. This difference was not statistically significant (p>0.05). The serum inhibin B concentration in controls was 201.5 ± 17.1 pg/mL, which was not statistically different from either untreated or interferon‐treated melanoma patients (p>0.05). We conclude that low‐dose interferon α does not have a significant (negative) effect on inhibin B or male fertility.
A Case of Primary Cutaneous Actinomycosis
Authors: Wee Seong Ho , Chang Sung Nam , Shim Jeong Yun , Chun Soo‐ll , Park Wook‐Hwa 
Published: April 2015

AbstractPrimary cutaneous actinomycosis is very uncommon because of the exclusively endogenous habitat of the organism. We report a case of primary cutaneous actinomycosis characterized by histopathological “sulfur granules”. The patient had a well‐defined subcutaneous nodule on the left thigh without any other lesion and was treated with surgical excision and subsequent oral ampicillin for six weeks. There has been no recurrence during a 1‐year period of follow‐up.
A Case of Black Dot Ringworm with a Review of Japanese Cases
Authors: Ooka Shiho , Kashima Masato , Kubota Yasuo , Noguchi Atsushi , Kawai Shinichi. , Nakamura Yuka , Kano Rui , Watanabe Shinichi , Hasegawa Atsuhiko , Mizoguchi Masako 
Published: April 2015

AbstractBlack dot ringworm (BDR), caused by Trichophyton violaceum var. glabrum (T. glabrum), was observed in a 28‐year‐old Japanese female who had been treated with prednisolone (22.5 mg/day) for systemic lupus erythematosus. It was successfully treated with oral terbinafine (125 mg/day) for 12 weeks. The causative fungus was identified by molecular analysis as well as morphological and biochemical examination. The chitin synthase 1 (CHS1) gene cleavage pattern of the clinical isolate with restricted enzyme HinfI was identical to that of T. violaceum. We reviewed previous reports of BDR to determine the historical trend of this infection in Japan. Since 1974, 93 Japanese cases have been reported. The age distribution was bi‐modal: the higher peak consisted of children (aged 0–15 years), and the lower peak was composed of the elderly (aged 60–75 years). In the elderly group, females were predominant (M: F=1: 22, p<0.001). T. violaceum, including T. glabrum, was identified as the most common causative fungus of BDR (75.3%). Sixty percent of cases showed slight erythema. In 8 families, 16 cases were found to be intrafamilial infections. A history of previous steroid treatment was described in about 40%.
Mal de Meleda: A Review of Turkish Reports
Authors: Ayman Taliha , Yerebakan Özlem , Yilmaz Ertan 
Published: April 2015

AbstractKeratoderma Palmoplantare Transgrediens or mal de Meleda (MDM) is a very rare, inherited disorder. Its name derives from the island of Meleda. Although, MDM has been reported from many different countries, only two Turkish patients with MDM have been reported in the international literature. Our six cases of MDM are reported, and retrospective analysis of published Turkish patients with MDM is included. We review the clinical characteristics, associated findings, consanguinity, and family history of the cases. In total, 26 Turkish cases of MDM including ours have been documented. Ten cases showed various nail abnormalities, the most common associated feature. We add 24 new cases from Turkey to the list in the literture. Our findings suggest that the MDM gene may also have originated elsewhere than in Mljet.
A Case of Vesiculo‐Bullous Darier's Disease Associated with Bipolar Psychiatric Disorder
Authors: Mei Sandra , Amato Lauretta , Gallerani Isabella , Perrella Esterina , Caproni Marzia , Palleschi Giovanni Maria , Fabbri Paolo 
Published: April 2015

AbstractWe describe the case of a 71‐year‐old men suffering from Darier's disease since his youth and presenting with intensely itching, vesicular and pustular lesions, localized on his arms, legs and on the ulnar side of his right hand. The patient also had a 30 year‐history of bipolar psychiaric disorders. The histopathological examination of lesional skin showed suprabasal acantholytic clefting, hyperparakeratosis, and dyskeratosis. Histopathological and immunopathological (direct and indirect immunofluorescence) results, were consistent with vesiculo‐bullous Darier's disease. Corticosteroid therapy with methylprednisolone at low dosage (0.2 mg/kg/day) was started with a quick resolution of the vesicular lesions on his arms and legs.
Novel Approaches to Chemoprevention of Skin Cancer
Authors: Bickers David R. , Athar Mohammad 
Published: April 2015

AbstractProtection against sun‐induced damage leading to photocarcinogenesis in skin is a highly desirable goal. Among various strategies, chemopreventive approaches utilizing non‐toxic agents to prevent the occurrence of precancerous lesions or their surrogate markers are potentially attractive. Epidemiological and experimental studies provide evidence that some naturally occurring chemical agents in the human diet can diminish cancer risk. Aside from water, tea is the most common beverage consumed worldwide. Black tea accounts for nearly 80% of total tea production. Black tea and green tea are derived from the same plant, Camelia sinensis. Green tea contains monomeric polyphenols known as flavanols and black tea contains dimeric flavanols and polymeric polyphenols known as theaflavins (TFs) and thearubigins (TRs). Over the past fifteen years our laboratory has been exploring the feasibility of using tea and its constituents as an approach to skin cancer prevention. We demonstrated that green tea, black tea and constituent polyphenols protect against chemical‐ and ultraviolet B (UVB)‐induced carcinogenesis and reduce the growth of established tumors in skin. We have also shown the efficacy of green and black tea extracts against UVB and psoralen + ultraviolet A (PUVA)‐induced early damage in skin. Although PUVA is highly effective in treating certain skin diseases, careful follow‐up studies of cohorts of patients have shown that similar to UVB, PUVA treatment increases the risk for cutaneous squamous cell carcinoma and melanoma. We have found that oral administration of a standardized green tea extract (SGTE) prior to and during treatment of SKH‐1 mice diminished PUVA‐induced skin hyperplasia and hyperkeratosis. SGTE‐treatment also inhibited PUVA‐induced accumulation of c‐fos and p53 proteins and epithelial hyperproliferation. Both topical application and oral administration of SGTE after PUVA‐treatment reduced skin inflammation and cell hyperproliferation. Topical application of SGTE to human skin prior to PUVA‐treatment inhibited the delayed skin inflammatory response. Similarly, oral and topical administration of standardized black tea extract (SBTE) and its two major polyphenolic sub‐fractions protect against UVB‐induced erythema in SKH‐1 mice. Furthermore, topical application of tea extracts to human volunteers protects against UVB‐induced erythema. In summary, these studies indicate that tea extracts are effective in reducing UVB‐ and PUVA‐mediated DNA damage, expression of early response genes and early inflammatory changes in skin. These studies verify a conceptual rationale for employing naturally occurring dietary constituents as an approach to cancer chemoprevention.
Lasers in Dermatology—A Critical Update
Authors: Anderson Richard Rox 
Published: April 2015

AbstractLasers are accepted for treating nevus of Ota, other pigmented lesions, hair removal, vascular lesions, leg veins, tattoos, and for skin resurfacing. These are photothermal treatments, in which certain skin “targets” are heated, followed by selective wound healing. Small pigmented targets such as the dermal melanocytes in nevus of Ota, are best treated with short (<1 μs) laser pulses. Large targets, such as hair follicles, have long thermal relaxation times and are best treated with longer pulses. In general, the ideal pulse duration is about equal to the thermal relaxation time for pigmented targets. However, sometimes the actual target is not pigmented and is at some distance from a pigmented structure. For example the follicular stem cells, which are not pigmented, line the outer root sheath far away from the pigmented hair shaft. These cells appear to be an important target for permanent hair destruction. Pulses longer than the thermal relaxation time of the hair shaft allow heat conduction and better damage of follicular stem cells. Epidermal cooling works far better with pulses longer than about 10 ms, delivered through a cold medium (e.g., cold sapphire in contact with the skin). Thus, the combination of cooling and long near‐infrared laser pulses allows safe and effective pigmented hair removal in all skin types. In contrast, epidermal protection from short pulses is best with dynamic pre‐cooling (e.g., cryogen spray), for example during portwine stain treatment. A major challenge for the future of photothermal laser treatments is to develop ways of treating non‐pigmented skin “targets”. New uses for lasers are emerging. Diagnostic laser imaging and spectroscopy will soon emerge in dermatology. A near‐infrared laser confocal microscope provides histology‐like images of human skin. Imaging is painless and takes only a few minutes. Lesions including melanoma, basal cell and squamous cell carcinoma, microvascular and inflammatory lesions, dermatophytes, verrucae, etc, have distinct appearances. However, sensitivity and specificity of laser‐based diagnostic imaging has not yet been compared with histopathology. Laser phototherapy is also emerging in dermatology. The 308 nm excimer laser has recently been shown to clear psoriasis faster than conventional phototherapy. Scalp psoriasis may soon be treated by fiber‐optic delivery of this UV laser. The variety and utility of lasers in dermatology will probably continue to grow.
Erythema Induratum Associated with Tuberculous Lymphadenitis: Analysis of a Case Using Polymerase Chain Reactions with Different Primer Pairs to Differentiate Bacille Calmette‐Guérin (BCG) from Virulent Strains ofMycobacterium tuberculosisComplex
Authors: Wang Tsun‐Cheng , Tzen Chin‐Yuan , Su Hsin‐Yi 
Published: April 2015

AbstractWe retrospectively analyzed a bacille Calmette‐Guérin (BCG) vaccinated female patient who developed erythema induratum in association with tuberculous lymphadenitis. The polymerase chain reaction (PCR) with two pairs of primers was performed. Only one pair was able to detect the myocobacterial DNA from the paraffin‐embedded specimen of the erythema induratum (EI) lesion. However, both pairs showed positive results with the tuberculous lymphadenitis specimen. Sequence analysis of the PCR products excluded the possibility of BCG as the potential pathogen. Both lesions responded favorably to antituberculous therapy. Our study attests to the tuberculous nature of EI and demonstrates that BCG vaccinationper sedoes not induce the lesion or interfere with the PCR result. Finally, using at least two pairs of primers targeting different genomic segments and possessing species‐identification capability may raise the detection rates and solve some controversies about the nature of tuberculids.
Pedunculated Atypical Cellular Blue Nevus
Authors: Ryou Ji‐Ho , Lim Tuk‐Woo , Lee Mu‐Hyoung , Haw Choong‐Rim 
Published: April 2015

AbstractAtypical variants of cellular blue nevus are considered to have features intermediate between typical cellular blue nevus and rare malignant blue nevus; they usually show bizarre pleomorphic cells which have prominent nucleoli. We describe a 37‐year‐old‐Korean woman who had had an asymptomatic pedunculated single mass on her right thigh for 17 years. A skin biopsy showed a tumor consisting of intensely pigmented dendritic cells and less or nonpigmented epitheloid cells in the dermis with striking atypia. There has been no evidence of recurrence for 3 years after surgery. The diagnosis of atypical cellular blue nevus was made on the basis of clinical features and skin biopsy findings.
Squamous Cell Carcinoma Arising in Chronic Perianal Pyoderma
Authors: Ishizawa Toshiyuki , Koseki Shin , Mitsuhashi Yoshihiko , Kondo Shigeo 
Published: April 2015

AbstractWe report a rare case of squamous cell carcinoma developing from fistules of chronic perianal pyoderma in a 49‐year‐old Japanese man. He first noticed an abscess and nodule on his buttocks and perianal area 21 year previously (at the age of 28); the fistules formed later. These fistules were surgically removed, and an artificial anus was constructed 14 years ago (at the age of 35) in our hospital, when a histopathological examination revealed no malignant changes. However, he was recently admitted to our hospital with arterial bleeding from the ulcer of the buttock. On admission, the histological diagnosis of the ulcer was well differentiated squamous cell carcinoma. Wide local excision of the ulcer and scar tissue, including the sacrum, was performed. The defect was covered with a left latissimus dorsi flap and skin graft. He received radiation therapy after the operation. However, he died of cachexia and pneumonia. This case indicated that the CPP would better have been treated with wide excision before the development of SCC. Therefore, we recommend careful follow‐up of patients affected by CPP and repeated biopsies of the lesion, particularly when the condition is severe, longstanding, and extensive. We discussed the term “CPP” and reviewed 22 cases of SCC arising in CPP reported in the Japanese literature.
Reticulate Acropigmentation of Kitamura: First Case Reports from Nepal
Authors: Joshi Arun , Sah Shatrughan P. 
Published: April 2015

AbstractTwo young Nepalese females, aged 34 and 17 years, presented with multiple small brown macules in a reticulate pattern on the distal extensor aspects of their limbs. The first patient's daughter also had similar lesions. The second patient had similar lesions on her eyelids and palmar pits as well. The clinical diagnosis of reticulate acropigmentation of Kitamura (RAK) was made in both the patients and was confirmed histopathologically. These are the first case reports of this condition from Nepal.
Non‐ulcerative Basal Cell Carcinoma
Authors: Takahashi Hiroyuki 
Published: April 2015

AbstractWe report two cases of basal cell carcinoma (BCC) arising on the genitalia. The first case was a 49‐year‐old male who became aware of a dull erythematous plaque with a keratotic surface on his scrotal skin, and the second case was a 44‐year‐old female suffering from a keratotic plaque on her right vulvar region. Neither lesion was ulcerative. Both were resected under local anesthesia following a clinical diagnosis of angiokeratoma for the former and seborrheic keratosis or BCC for the latter lesion. Histopathological study revealed that both lesions were BCC. Many questions regarding the pathogenesis of BCC still remain to be clarified. Because most of the reported cases have been ulcerative lesions and the genital region is an uncommon site for BCCs, caution should be taken in cases in whom a clinically non‐ulcerative tumor suspected to be angiokeratoma or seborrheic keratosis arises in this region.
The relationship between the frequency of self‐monitoring of blood glucose and glycemic control in patients with type 1 diabetes mellitus on continuous subcutaneous insulin infusion or on multiple daily injections
Authors: Murata Takashi , Tsuzaki Kokoro , Yoshioka Fumi , Okada Hiroshi , Kishi Junichiro , Yamada Kazunori , Sakane Naoki 
Published: April 2015

AbstractAims/IntroductionWe investigated the relationship between the frequency of self‐monitoring of blood glucose (SMBG) and glycemic control in type 1 diabetes mellitus patients on continuous subcutaneous insulin infusion (CSII) or on multiple daily injections (MDI) using data management software.Materials and MethodsWe recruited 148 adult type 1 diabetes mellitus patients (CSII n = 42, MDI n = 106) and downloaded their SMBG records to the MEQNET™ SMBG Viewer software (Arkray Inc., Kyoto, Japan). The association between the SMBG frequency and the patients' hemoglobin A1c (HbA1c) levels was analyzed using the χ2‐test and linear regression analysis was carried out to clarify their relationship.ResultsThe odds ratio of achieving a target HbA1c level of <8% (63.9 mmol/mol) was significantly higher in subjects with SMBG frequencies of ≥3.5 times/day compared with those with SMBG frequencies of <3.5 times/day in the CSII group (odds ratio 7.00, 95% confidence interval 1.72–28.54), but not in the MDI group (odds ratio 1.35, 95% CI 0.62–2.93). A significant correlation between SMBG frequency and the HbA1c level was detected in the CSII group (HbA1c [%] = –0.24 × SMBG frequency [times/day] + 8.60 [HbA1c {mmol/L} = –2.61 × SMBG frequency {times/day} + 70.5], [r = –0.384, P = 0.012]), but not in the MDI group.ConclusionsA SMBG frequency of <3.5 times per day appeared to be a risk factor for poor glycemic control (HbA1c ≥8%) in type 1 diabetes mellitus patients on CSII.
Lack of predictive power of plasma lipids or lipoproteins for gestational diabetes mellitus in Japanese women
Authors: Iimura Yuko , Matsuura Masaaki , Yao Zemin , Ito Satoru , Fujiwara Mutsunori , Yoshitsugu Michiyasu , Miyauchi Akito , Hiyoshi Toru 
Published: April 2015

AbstractAims/IntroductionTo determine the diagnostic potential of plasma lipids and apolipoproteins in gestational diabetes mellitus (GDM), we carried out a retrospective cohort study of 1,161 Japanese women at 20–28 weeks of gestation who underwent a glucose challenge test (GCT).Materials and MethodsA total of 1,161 Japanese women at 20–28 weeks of gestation underwent a GCT. Participants with a positive test (GCT[+]) underwent a subsequent oral glucose tolerance test. Clinical and biochemical parameters were determined and quantification of apolipoproteins (Apo), including ApoB, ApoB48, ApoA‐I and ApoC‐III, was carried out.ResultsThe prevalence of GCT(+; with a 130 mg/dL glucose cut‐off) and GDM was 20% and 4%, respectively. There was a trend for increased triglycerides and ApoC‐III in GDM(+) participants. However, the difference in plasma triglycerides, ApoC‐III or ApoB48 did not reach statistical significance between GDM(+) and GDM(−) women. Values of 1‐h glucose (P < 0.001) and fasting glucose (P = 0.002) were significant risk factors for GDM.ConclusionsPrediction of GDM using only the ApoC‐III value is not easy, although triglycerides and ApoC‐III were higher in the GDM(+) group. The present findings show no significant difference in plasma lipid levels between women diagnosed with GDM and those with normal glucose tolerance.