bluuebunny/crossref_metadata_2025_split huggingface dataset:
The investment and regenerative value of addiction treatment
Authors: Iafrati Steve 
Published: February 2015

Purpose
– The purpose of this paper is to show that despite welfare retrenchment and political rhetoric towards welfare, spending on residential addiction treatment should be protected.

Design/methodology/approach
– Examining benefits in context of costs, the research used social return on investment to monetise benefits and compare with costs. Based at a residential addiction centre, the research used questionnaires and focus groups with residents and former residents.

Findings
– The centre created almost £4 of benefit for every £1 of cost. Whilst the bulk of savings came from health, housing and criminal justice, there was also a regenerative impact for the local economy.

Research limitations/implications
– Sampling in sensitive themes is always problematic, however, the research had contact with many respondents, achieved data saturation and used the centre's success rate as a guide to weight the findings.

Practical implications
– The benefits of addiction treatment go beyond health outcomes and raise questions about how this should be reflected in cost distribution. Consequently, this has implications for the ways in which addiction services should be measuring their successes beyond solely health outcomes.

Social implications
– Existing research has largely overlooked the benefit of addiction treatment to the local economy and the fact that, as an investment, this benefit will continue to grow as more people enter the labour market over time.

Originality/value
– The research recognises the political context of funding and measures success beyond solely health outcomes. Furthermore, the research recognises the regenerative impact of addiction treatment, which is often overlooked in similar research.
The X factor that can help to motivate Generation Y
Authors: Sreejith S.S. 
Published: February 2015

Purpose
– Explains why performance evaluation designed for manufacturers is inappropriate for information technology organizations.

Design/methodology/approach
– Underlines the distinctiveness of the information technology workforce and provides the basis for an effective performance- evaluation system designed for these workers.

Findings
– Highlights the roles of consensus and transparency in setting and modifying evaluation criteria.

Practical implications
– Urges the need for a fair and open rewards and recognition system to run in parallel with reformed performance evaluation.

Social implications
– Provides a way of updating performance evaluation systems to take account of the move from manufacturing to information technology-based jobs in many developed and developing societies.

Originality/value
– Reveals how best to recognize, reward and assess the performance of information technology workers.
Qualitatively exploring hearing voices network support groups
Authors: Dos Santos Bianca , Beavan Vanessa 
Published: February 2015

Purpose
– The distress that is associated with auditory hallucinations, or voices, is well documented. However, increasingly research into this phenomenon is also capturing those who cope with their voices, and live meaningful lives. Peer support is a popular and useful way in which to learn to manage the distress for voice-hearers. The Hearing Voices Network (HVN) acts as an umbrella organisation for which research, training and peer support groups exist (www.intervoiceonline.org). Despite the growing amount of peer support groups established, there is to date no published material on these groups. The purpose of this paper is to discuss these issue.

Design/methodology/approach
– The present study used Interpretive Phenomenological Analysis to explore the experiences of four informants across three New South Wales HVN groups.

Findings
– Results suggest that the social connections, value of sharing and desire for more group members are all important within the group. Beyond the group, informants described the increased willingness to talk to others about their voice experiences, improvements in sense of self and a positive change in their relationship with their voices.

Originality/value
– The study demonstrates the importance of peer participation in the mental health workforce and the provision of safe spaces for those with lived experience to share and learn from each other in meaningful ways. Research implications include the need for further research measuring outcomes on a larger scale for these support groups.
Peer-led self-management for people with severe mental disorders: an economic evaluation
Authors: Iemmi Valentina , Crepaz-Keay David , Cyhlarova Eva , Knapp Martin 
Published: February 2015

Purpose
– The purpose of this paper is to evaluate the effectiveness and cost-effectiveness of a peer-led self-management intervention for people with severe mental disorders.

Design/methodology/approach
– This is a one-arm longitudinal study without control group. In all, 262 adults with (self-reported) severe mental disorders, who have used secondary mental health services and were living in the community were evaluated at three time points (baseline, six and 12 months). Socio-demographic data were collected at baseline. Wellbeing (Warwick-Edinburgh Mental Wellbeing Scale), functional living skills (Health Promoting Lifestyle Profile II) and service use (Client Service Receipt Inventory) data were assessed over time.

Findings
– Self-management for people with severe mental disorders improved wellbeing and health-promoting lifestyles. After an increase in the short term, costs appeared to decrease in the longer term, although this change was not statistically significant. Due to the lack of a control group, the authors are unable to attribute those changes to the intervention only. Nevertheless, the self-management intervention appears to warrant further attention on both wellbeing and economic grounds.

Originality/value
– Self-management may facilitate recovery, helping to support people with severe mental disorders at no additional cost. Given recent emphasis on recovery, peer workers and self-management, this peer-led self-management approach for people with severe mental disorders appears to have potential.
Enhancing recovery: transition intervention service for return to the community following exit from an alternative to psychiatric inpatient admission – a residential recovery house
Authors: Griffiths Christopher Alan , Heinkel Samira , Dock Bohdana 
Published: February 2015

Purpose– The purpose of this paper is to evaluate the impact on recovery and personal goal attainment of a transition intervention service for return to the community following exit from an alternative to psychiatric inpatient admission – a residential recovery house. The services seek to facilitate community reintegration, promote recovery and prevent future mental health crisis. The service was funded by the Stone Family Foundation.Design/methodology/approach– This evaluation employed a within groups design: a single case evaluation follow-up. Analysis of Recovery Star and personal goal achievement data collected at service entry and exit points during routine practice (n=181), at four sites in England. The adults had mental illness diagnoses including depression, schizophrenia, bipolar disorder, personality disorder, and anxiety disorder.Findings– There was a significant increase in overall Recovery Star scores with a large effect size, and significant increases in eight of the ten Recovery Star life domains. There were significant increases in the goal scores linked to “Managing mental health”, “Self-care” and “Living skills”.Practical implications– A transitional intervention service provided by the third sector for return to community following mental health crisis may contribute to recovery and personal goal achievement. A randomised control trial of this transition intervention service is recommended.Originality/value– This is first outcome evaluation of an alternative to psychiatric inpatient admission transition intervention service and findings indicate the potential positive effect of having this service incorporated into the design of alternative to admission provision.
Transitioning to nontoxic antifouling paints
Authors: García Mónica , Stupak Mirta , Pérez Miriam , Blustein Guillermo 
Published: February 2015

Purpose
– The purpose of this paper is to reduce the amount of copper in antifouling paints by using eugenol as an additive. Biofouling leads to deterioration of any submerged material. The most widespread method for control is the application of cuprous oxide antifouling paints which are toxic. First of all, the paper describes the effect of eugenol on larvae of Balanus amphitrite (fouling organism) under laboratory conditions and then the preparation, application and performance of different types of antifouling paints in field trials.

Design/methodology/approach
– Three types of soluble matrix antifouling paints were prepared with different pigments. The first one containing 16 per cent v/v copper, the second with 1.6 per cent copper and the third with 1.6 per cent copper + 2 per cent eugenol.

Findings
– After 12 months of immersion in Mar del Plata harbour paints containing 1.6 per cent copper + eugenol and 16 per cent copper were the most effective. Although these formulations showed a similar performance, copper + eugenol-based paint contains 90 per cent lesser copper than a traditional copper-based formulation.

Originality/value
– The use of antifouling paints with copper + eugenol combination as pigment is a promising alternative due to its performance, low cost and reduction in copper leaching to environment.
Metagenomic characterization of viral communities in corals: mining biological signal from methodological noise
Authors: Wood‐Charlson Elisha M. , Weynberg Karen D. , Suttle Curtis A. , Roux Simon , van Oppen Madeleine J. H. 
Published: February 2015

SummaryReef‐building corals form close associations with organisms from all three domains of life and therefore have many potential viral hosts. Yet knowledge of viral communities associated with corals is barely explored. This complexity presents a number of challenges in terms of the metagenomic assessments of coral viral communities and requires specialized methods for purification and amplification of viral nucleic acids, as well as virome annotation. In this minireview, we conduct a meta‐analysis of the limited number of existing coral virome studies, as well as available coral transcriptome and metagenome data, to identify trends and potential complications inherent in different methods. The analysis shows that the method used for viral nucleic acid isolation drastically affects the observed viral assemblage and interpretation of the results. Further, the small number of viral reference genomes available, coupled with short sequence read lengths might cause errors in virus identification. Despite these limitations and potential biases, the data show that viral communities associated with corals are diverse, with double‐ and single‐stranded DNA and RNA viruses. The identified viruses are dominated by double‐stranded DNA‐tailed bacteriophages, but there are also viruses that infect eukaryote hosts, likely the endosymbiotic dinoflagellates, Symbiodinium spp., host coral and other eukaryotes in close association.
A Case of Accidental Fatal Aluminum Phosphide Poisoning Involving Humans and Dogs
Authors: Behera Chittaranjan , Krishna Karthik , Bhardwaj Daya Nand , Rautji Ravi , Kumar Arvind 
Published: February 2015

AbstractAluminum phosphide is one of the commonest poisons encountered in agricultural areas, and manner of death in the victims is often suicidal and rarely homicidal or accidental. This paper presents an unusual case, where two humans (owner and housemaid) and eight dogs were found dead in the morning hours inside a room of a house, used as shelter for stray dogs. There was allegation by the son of the owner that his father had been killed. Crime scene visit by forensic pathologists helped to collect vital evidence. Autopsies of both the human victims and the dogs were conducted. Toxicological analysis of viscera, vomitus, leftover food, and chemical container at the crime scene tested positive for aluminum phosphide. The cause of death in both humans and dogs was aluminum phosphide poisoning. Investigation by police and the forensic approach to the case helped in ascertaining the manner of death, which was accidental.
The impact of human papillomavirus infection on the survival and treatment response of patients with esophageal cancers
Authors: Wang Wen‐Lun , Wang Yu‐Chi , Lee Ching‐Tai , Chang Chi‐Yang , Lo Jo‐Lin , Kuo Yao‐Hung , Hsu Yao‐Chun , Mo Lein‐Ray 
Published: February 2015

ObjectiveThis study aimed to investigate the impact of human papillomavirus (HPV) infection on the prognosis and treatment response of esophageal squamous cell carcinoma (ESCC).MethodsWe examined the presence and subtypes of HPV in the tumors by polymerase chain reaction and sequencing in 150 ESCC patients. Their clinicopathological characteristics, treatment response and survival were further analyzed according to the presence of HPV infection.ResultsOf 150 ESCC tumor samples, 27 (18.0%) were HPV‐positive, of which 22 (81.5%) had HPV‐16 infection. The risk of developing multifocal ESCC was not significantly different in the HPV‐positive and HPV‐negative groups (29.6% vs 28.5%, P = 0.90). In subgroup analysis, patients with HPV‐16‐positive advanced ESCC had a significantly better survival than those with HPV‐negative ESCC (3‐year survival: 55% vs 21%, log–rank P = 0.03). Cox proportional hazards model showed that the presence of HPV‐16 was associated with a significant reduction in the mortality rate (hazard ratio 0.41, 95% CI 0.18–0.96). Patients with HPV‐16 infection had better response to chemoradiotherapy (CRT) than those without HPV‐16 infection (P = 0.026).ConclusionsIn patients with advanced ESCC, HPV‐16‐positive patients had a significantly favorable survival, especially those who received CRT. Larger scale studies are needed to determine the causal relationship.
High treatment modification rates with lamivudine therapy in HBV‐infected patients with low baseline viremia and early virological response: A multicenter study
Authors: Gonen Can , Gunduz Feyza , Doganay Levent , Enc Feruze Y , Yegin Ender G , Ahishali Emel , Erdem Emrullah , Sokmen Mehmet , Tuncer Ilyas , Ozdogan Osman 
Published: February 2015

ObjectiveLow baseline viremia and an early treatment response predict the best outcomes in hepatitis B virus (HBV)‐infected patients treated with nucleoside analogues with low barriers to resistance. The aim of this study was to assess the long‐term results and effectiveness of lamivudine in patients with low baseline viremia and early virological treatment response.MethodsIn this multicenter, real‐life setting study, 111 antiviral‐naive patients with low baseline viremia (HBV DNA <107 copies/mL) plus an early virological response (HBV DNA <300 copies/mL at week 24) treated with lamivudine were enrolled. The primary end‐point was treatment failure, defined as the re‐emergence of detectable viremia or at least a 1 log increase in HBV DNA, resulting in a titer of ≥300 copies/mL with lamivudine treatment after week 24, which required treatment modification.ResultsAltogether 111 patients, including 78 non‐cirrhotic and 33 cirrhotic patients, were included in the study. Treatment failure occurred in 30.8% of the non‐cirrhotic patients over a median follow‐up period of 32.5 months, and the 1‐, 2‐, 3‐, 4‐ and 5‐year treatment failure rates were 6.5%, 14.0%, 31.4%, 39.6% and 43.1%, respectively. Treatment failure occurred in 28.8% of the whole group. There were no differences between the cirrhotic and non‐cirrhotic patients.ConclusionsLamivudine treatment had a high treatment modification rate in patients with low baseline viremia and early virological response over a long‐term follow‐up in a real‐life setting. The pretreatment and on‐treatment favorable characteristics found in the studies with telbivudine appeared to be inapplicable to lamivudine.
The genotype CC of IL‐28B SNP rs12979860 is significantly associated with a sustained virological response in chronic HCV‐infected Pakistani patients
Authors: Khubaib Bushra , Saleem Sana , Idrees Muhammad , Afzal Samia , Wasim Muhammad 
Published: February 2015

ObjectiveTo evaluate the association of genetic variation in interleukin 28B (IL‐28B) gene and viral factors with treatment outcome in chronic hepatitis C virus (HCV)‐infected patients in Pakistan.MethodsPatients with chronic HCV infection who received interferon plus ribavirin combination therapy were enrolled in the study. The viral loads were checked at the third and sixth month of treatment and 6 months after the completion of the treatment. Genotyping of single‐nucleotide polymorphism (SNP) rs12979860 of IL‐28B gene was performed by the restriction fragment length polymorphism method and direct sequence analysis.ResultsA total of 111 patients successfully completed antiviral therapy and the follow‐up period. Early virological response (EVR) and a sustained virological response (SVR) were achieved in 92 and 91 patients, respectively. Patients infected with HCV genotype 3a had a higher SVR rate compared with other HCV genotypes. A higher C allele frequency (81.9%) was observed in patients with SVR than those with non‐SVR (P = 0.00001). The odds ratio of achieving SVR was more than 10‐fold greater for the CC genotype than the CT/TT genotypes of SNP rs12979860 (OR 10.351, 95% CI 1.925–55.653, P = 0.006). Other positive predictors observed for SVR were female gender and EVR.ConclusionThe CC genotype of IL‐28B SNP rs12979860 is an independent predictive factor for SVR in chronic HCV‐infected patients in Pakistan.
Mammographically screen‐detected asymmetric densities with architectural distortion and normal ultrasound at assessment: Value of MRI as a problem‐solving tool
Authors: Price Jeremy , Chen Suet Wan 
Published: February 2015

SummaryFour cases are presented in which asymptomatic clients from an Australian mammography screening programme (BreastScreen ACT) were recalled for assessment of an asymmetric density with possible architectural distortion. In all four women, mammographic work‐up was equivocal and ultrasound showed no suspicious correlate for biopsy. It was then doubtful as to whether any significant lesion was present. In all four cases, MRI revealed the presence of malignancy. Breast MRI can be a useful problem‐solving tool in the work‐up of such cases.
Duplex kidney: Not just a drooping lily
Authors: Doery Ashlea J , Ang Eileen , Ditchfield Michael R 
Published: February 2015

AbstractIntroductionDuplex kidneys are common, mostly asymptomatic and of no clinical significance. However, they can be associated with significant pathology, often with long‐term morbidity. There is minimal literature on the review of the duplex kidney, its associated anomalies and complications. The purpose of this paper is to review our experience of imaging the spectrum of abnormalities associated with duplex kidneys in the paediatric population and correlate this with contemporary literature.MethodA retrospective review of the radiology database in a tertiary paediatric centre was performed. A word search of the Radiology Information System for ‘duplex’ of patients under the age of 16 was undertaken and limited to studies performed between 2006 and 2013.ResultsTwo hundred seventy‐four patients were identified (age range 0–16, median 3 years, gender 59.9% female) who had 836 studies: ultrasound 598/836 (71.6%), nuclear medicine 180/836 (21.5%), micturating cystourethrogram 52/836 (6.2%), MRI 5/836 (<1%) and CT scan 1/836 (<1%). Patients were categorised as duplex and no complication (151/274 = 55.1%), upper moiety obstruction, lower moiety reflux/scarring, multicystic dysplastic kidney, abnormal ureteric insertion and other pathology.ConclusionDuplex kidneys are common and often not clinically significant. However, this study demonstrates almost 50% of paediatric patients investigated for duplex kidneys had complications requiring treatment. The most common complications were upper moiety obstruction associated with a ureterocele and lower moiety vesicoureteric reflux. Ultrasound was the most common modality for early detection of these complications.
Intra‐tumour 18F‐FDG uptake heterogeneity decreases the reliability on target volume definition with positron emission tomography/computed tomography imaging
Authors: Dong Xinzhe , Wu Peipei , Sun Xiaorong , Li Wenwu , Wan Honglin , Yu Jinming , Xing Ligang 
Published: February 2015

AbstractIntroductionThis study aims to explore whether the intra‐tumour 18F‐fluorodeoxyglucose (FDG) uptake heterogeneity affects the reliability of target volume definition with FDG positron emission tomography/computed tomography (PET/CT) imaging for nonsmall cell lung cancer (NSCLC) and squamous cell oesophageal cancer (SCEC).MethodsPatients with NSCLC (n = 50) or SCEC (n = 50) who received 18F‐FDG PET/CT scanning before treatments were included in this retrospective study. Intra‐tumour FDG uptake heterogeneity was assessed by visual scoring, the coefficient of variation (COV) of the standardised uptake value (SUV) and the image texture feature (entropy). Tumour volumes (gross tumour volume (GTV) ) were delineated on the CT images (GTVCT), the fused PET/CT images (GTVPET‐CT) and the PET images, using a threshold at 40% SUVmax (GTVPET40%) or the SUV cut‐off value of 2.5 (GTVPET2.5). The correlation between the FDG uptake heterogeneity parameters and the differences in tumour volumes among GTVCT, GTVPET‐CT, GTVPET40% and GTVPET2.5 was analysed.ResultsFor both NSCLC and SCEC, obvious correlations were found between uptake heterogeneity, SUV or tumour volumes. Three types of heterogeneity parameters were consistent and closely related to each other. Substantial differences between the four methods of GTV definition were found. The differences between the GTV correlated significantly with PET heterogeneity defined with the visual score, the COV or the textural feature‐entropy for NSCLC and SCEC.ConclusionsIn tumours with a high FDG uptake heterogeneity, a larger GTV delineation difference was found. Advance image segmentation algorithms dealing with tracer uptake heterogeneity should be incorporated into the treatment planning system.
Analysis of lymph node impact on conversion of complete thoracoscopic lobectomy to open thoracotomy
Authors: Li Yun , Wang Jun 
Published: February 2015

AbstractBackgroundThe aim of the study was to analyze the influence of lymph nodes in conversion thoracotomy and its measurements.MethodBetweenSeptember 2006 toApril 2013, 1006 patients (545 men, 461 women, median age 60 years, range: 13 to 86 years) received a complete thoracoscopic lobectomy. The main procedure was complete video‐assisted anatomical lobectomy with mediastinal lymphadenectomy.ResultsAll procedures were carried out smoothly without serious complication. Eighty‐three cases were converted to thoracotomy (8.2%), including 70 cases of initiative conversion and 13 of passive conversion, in which 59 cases had interference by doornail lymph nodes. The average operative time was significantly longer (272.7 ± 67.2 vs. 186.9 ± 58.1 minutes,P= 0.001); the average blood loss was significantly increased (564.2 ± 507.7 ml vs. 158.0 ± 121.0 ml,P= 0.001); and the drainage time and postoperative hospital stay were significantly longer (8.9 ± 5.0 vs. 6.6 ± 3.5 days,P= 0.001; 12.5 ± 7.7 vs. 9.2 ± 5.8 days,P= 0.001, respectively) in the conversion thoracotomy compared with the complete endoscopic surgery group.ConclusionInterference of the lymph nodes was the main reason for conversion to thoracotomy on video‐assisted thoracoscopic lobectomy, which prolonged operative time, increased the blood loss during surgery, and delayed postoperative recovery. Selecting the proper indication of conversion thoracotomy may reduce the negative effects.