bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developmental small RNA transcriptomics reveals divergent evolution of the conserved microRNAmiR-100and thelet-7-complexin nematodes
Authors: Sharma Devansh Raj , Röseler Waltraud , Witte Hanh , Werner Michael S. , Sommer Ralf J. 
Published: July 2024

AbstractSmall RNAs have emerged as one of the key post-transcriptional regulators and can be broadly categorised into microRNAs (miRNAs), small-interfering RNAs (siRNAs), and PIWI-interacting RNAs (piRNAs). Since their discovery as regulators of developmental timing in the nematodeCaenorhabditis elegans, some miRNAs were found to be highly conserved throughout animal evolution. miR-100 is a highly conserved miRNA, possibly predating the origin of bilaterians. Furthermore,miR-100is a member of the conservedlet-7-complex, a locus containing three ancient miRNA-coding genes (miR-100,let-7,miR-125/lin-4) that has been secondarily lost inC. elegans. Here, we performed small RNA-sequencing across development in the satellite nematodePristionchus pacificus, identifying miR-100 as the most abundant miRNA in post-embryonic juvenile stages. Additionally,P. pacificusexhibited a novel constellation of thelet-7- complex, whereinmir-100is closely linked tolet-7, but withoutlin-4in the same locus. Knockouts ofmir-100,let-7, andmir-100 let-7double mutants inP. pacificusresulted in viable worms with developmental defects related to dysregulation of collagen. Surprisingly,lin-4mutants showed nearly normal development. This study provides the first developmental small RNA transcriptome inP. pacificus, and indicates that thelet-7-complexand small RNA pathways undergo rapid evolutionary divergence in nematodes.
A high-performance genetically encoded sensor for cellular imaging of PKC activityin vivo
Authors: Yahiro Takaki , Bayless-Edwards Landon , Jones James A. , Ma Lei , Qin Maozhen , Mao Tianyi , Zhong Haining 
Published: July 2024

AbstractWe report a genetically encoded fluorescence lifetime sensor for protein kinase C (PKC) activity, named CKAR3, based on Förster resonance energy transfer. CKAR3 exhibits a 10-fold increased dynamic range compared to its parental sensors and enablesin vivoimaging of PKC activity during animal behavior. Our results reveal robust PKC activity in a sparse neuronal subset in the motor cortex during locomotion, in part mediated by muscarinic acetylcholine receptors.
Conscious and Unconscious Emotional Processing: Insights from Behavioral and Pupillary Responses
Authors: Taghavi Helia , Sharbaf Leila , Ismailzad Fatemeh , Vahabie Abdol-Hossein , Hatami Javad , Rezayat Ehsan 
Published: July 2024

AbstractEmotions are crucial in social interactions, influencing communication and relationships. Distinguishing the perceived emotion in conscious and unconscious emotional processing is a key research area with cognitive and physiological implications. This study investigates conscious and unconscious emotional processing through behavioral and pupillary responses. Participants completed emotion recognition tasks under varying states, revealing higher accuracy in conscious emotion identification. Emotions like anger, happiness, fear, surprise, and neutral elicited distinct response patterns. Pupillometry data showed pupil size suppression in the conscious state and enhancement in the unconscious state, with differences in peak pupil size across emotions. Task-related components, amplitude, and latency parameters differed between conscious and unconscious states, highlighting the role of awareness in emotional regulation. These findings emphasize the complex interplay of cognitive and physiological processes in emotional responses, providing insights into emotional recognition mechanisms. This study contributes to understanding emotional processing dynamics and has implications for psychology and neuroscience research.
Transform the Information Landscape Applying Waddington Landscape to Information Theory of Aging and Epigenetic Rejuvenation
Authors: Wu Yue 
Published: July 2024

AbstractThe Information Theory of Aging (ITOA) provides a framework for understanding aging and rejuvenation via changes in epigenetic information. These changes are visualized using Waddington landscape — a 3D topology that represents cell trajectories during changes in cell identity — constructed from field decomposition of scRNA velocity data. Studies have demonstrated that the Waddington landscape can serve as a mechanistic model of epigenetic information. It explains how age-driven decline in cellular function and reprogramming-induced rejuvenation can be understood by studying the transformations in the Waddington landscape. This study provides insights into the representation of epigenetic information and discusses how it can be reprogrammed to restore a younger cellular state.
Long shared haplotypes identify the Southern Urals as a primary source for the 10th century Hungarians
Authors: Gyuris Balázs , Vyazov Leonid , Türk Attila , Flegontov Pavel , Szeifert Bea , Langó Péter , Mende Balázs Gusztáv , Csáky Veronika , Chizhevskiy Andrey A. , Gazimzyanov Ilgizar R. , Khokhlov Aleksandr A. , Kolonskikh Aleksandr G. , Matveeva Natalia P. , Ruslanova Rida R. , Rykun Marina P. , Sitdikov Ayrat , Volkova Elizaveta V. , Botalov Sergei G. , Bugrov Dmitriy G. , Grudochko Ivan V. , Komar Oleksii , Krasnoperov Alexander A. , Poshekhonova Olga E. , Chikunova Irina , Sungatov Flarit , Stashenkov Dmitrii A. , Zubov Sergei , Zelenkov Alexander S. , Ringbauer Harald , Cheronet Olivia , Pinhasi Ron , Akbari Ali , Rohland Nadin , Mallick Swapan , Reich David , Szécsényi-Nagy Anna 
Published: July 2024

AbstractDuring the Hungarian Conquest in the 10th century CE, the early medieval Magyars, a group of mounted warriors from Eastern Europe, settled in the Carpathian Basin. They likely introduced the Hungarian language to this new settlement area, during an event documented by both written sources and archaeological evidence. Previous archaeogenetic research identified the newcomers as migrants from the Eurasian steppe. However, genome-wide ancient DNA from putative source populations has not been available to test alternative theories of their precise source. We generated genome-wide ancient DNA data for 131 individuals from candidate archaeological contexts in the Circum-Uralic region in present-day Russia. Our results tightly link the Magyars to people of the Early Medieval Karayakupovo archaeological horizon on both the European and Asian sides of the southern Urals. Our analyes show that ancestors of the people of the Karayakupovo archaeological horizon were established in the Southern Urals by the Iron Age and that their descendants persisted locally in the Volga-Kama region until at least the 14th century.
Context-driven interaction retrieval and classification for modeling, curation, and reuse
Authors: Luo Haomiao , Hansen Casey , Telmer Cheryl A. , Tang Difei , Arazkhani Niloofar , Zhou Gaoxiang , Spirtes Peter , Miskov-Zivanov Natasa 
Published: July 2024

AbstractComputational modeling seeks to construct and simulate intracellular signaling networks to understand health and disease. The scientific literature contains descriptions of experimental results that can be interpreted by machines using NLP or LLMs to itemize molecular interactions. This machine readable output can then be used to assess, update or improve existing biological models if there is a tool for comparing the existing model with the information extracted from the papers. Here we describe VIOLIN a tool for classifying machine outputs of molecular interactions with respect to a biological model. VIOLIN classifies interactions as corroborations, contradictions, flagged or extensions with subcategories of each class. This paper analyzes 2 different models, 9 reading sets, 2 NLP and 2 LLM tools to test VIOLIN’s capabilities. The results show that VIOLIN successfully classifies interaction types and can be combined with automated filtering to provide a versatile tool for use by the systems biology community.
Trait anxiety impairs reciprocity behavior: A multi-modal and computational modeling study
Authors: Fang Huihua , Wang Rong , Wang Zhihao , Liu Qian , Luo Yuejia , Xu Pengfei , Krueger Frank 
Published: July 2024

AbstractAnxiety significantly impacts reciprocal behavior, crucial for positive social interactions. The neurocomputational mechanisms of anxiety’s effects on the core (individual propensity) and peripheral (decision context) factors shaping reciprocity remain unclear. Here, we investigated reciprocity in individuals with low and high trait anxiety using a binary trust game with gain/loss framing, combining computational modeling, eye-tracking, and event-related potentials (ERPs). Our computational model, validated by eye-tracking data, identified four psychological components driving reciprocal behavior: reward, guilt aversion, superiority aversion, and superiority attraction. Regarding the core of reciprocity, trait anxiety diminished both overall reciprocity and specific psychological components like guilt aversion and superiority attraction, irrespective of context. The reduction in guilt aversion was supported by ERP findings showing decreased P2 (selective attention) and increased LPP (emotion regulation) amplitudes in anxious individuals. Regarding the periphery of reciprocity, trait anxiety altered the contextual perception of both superiority aversion and reward. Further, trait anxiety reversed the perception of superiority aversion from gain to loss contexts, a pattern that was linked to the N2 amplitudes (cognitive control). Our findings revealed distinct effects of trait anxiety on core and peripheral factors in reciprocity, offering potential targets for interventions aimed at improving reciprocity in individuals with anxiety disorders.
The AbilityQuotient Dashboard: Outcomes of Implementing Patient-Specific Predictive Modeling in Inpatient Team Conference
Authors: Sliwa James A. , Carpenter Julia , Bodine Andrew , Deom Caitlin , Lieber Richard L 
Published: July 2024

AbstractObjectiveRecent reports have highlighted the importance of data-driven decision making as it relates to precision medicine and the field of rehabilitation. One promising method to facilitate the integration of data into patient care involves the use of data warehousing to process and host patient data, analytics to produce useful results, and dashboarding technology to disseminate analytical results to care teams in a digestible and interpretable format. This report describes the implementation of a new composite rehabilitation outcome score (cROS), the AbilityQuotient, and predictive modeling into inpatient interdisciplinary conferences through a patient data dashboard and its impact on outcomes.DesignSettingInpatient Rehabilitation HospitalParticipants13,397 patients completing inpatient rehabilitation from January 1, 2019 to December 31, 2023InterventionA patient centered, composite rehabilitation outcome score (cROS) and predictive modeling dashboard implemented into team conferenceMain Outcome MetricsSelf-care and mobility IRF-PAI Form GG change scores, length of stay pre- and post-dashboard implementation; GG change scores compared to weighted national averages; clinician survey regarding perspectives of dashboard use; GG item long term goal modifications and goal attainment as a measure of influence on clinical plan of careResultsAfter implementation of the patient outcomes dashboard into routine care, IRF-PAI Form GG self-care scores rose by 2.09 points and corresponding mobility scores rose by 7.18 points despite a 2.29 day reduction in length of stay. Further exploration investigating these changes as they pertained to payor revealed that these benefits occurred irrespective of insurer. Reports comparing facility to national averages extracted from eRehabData, a national outcomes data system and registry, suggest that the use of the outcomes dashboard resulted in greater reductions in length of stay and greater improvements in functional outcomes during the 2019-2023 period compared to the previous period. A corresponding survey assessing clinical perceptions of dashboard implementation revealed that it facilitated tracking and summarizing patient progress, reinforced the use of outcome metrics, and was perceived as valuable in goal setting and adjustment. Clinicians modified self-care goals six times more frequently and patients met these goals 19% more of the time after introduction of the cROS while they changed mobility goals nine times more frequently and patients met these goals 21% more of the time after introduction.ConclusionThe incorporation of individual patient data and predictive modeling into rehabilitation patient care through use of a team conference dashboard has potential to provide an objective basis from which to perform precision rehabilitation. It also has the potential to impact outcome metrics improving value-based care and consequently deserves further study.
Osteoprotegerin (OPG) and its ligands RANKL and TRAIL in falciparum, vivax and knowlesi malaria: correlations with disease severity, and B cell production of OPG
Authors: Nair Arya Sheela , Woodford John , Loughland Jessica , Andrew Dean , Piera Kim , Amante Fiona , William Timothy , Grigg Matthew J , McCarthy James S , Anstey Nicholas M , Boyle Michelle J , Barber Bridget E 
Published: July 2024

ABSTRACTOsteoprotegerin (OPG) is a soluble decoy receptor for receptor activator of NF-ƙB ligand (RANKL) and TNF-related apoptosis-inducing ligand (TRAIL), and is increasingly recognised as a marker of poor prognosis in a number of diseases. Here we demonstrate that in Malaysian adults with falciparum and vivax malaria, OPG is increased, and its ligands TRAIL and RANKL decreased, in proportion to disease severity. In volunteers experimentally infected withP. falciparumandP. vivax, RANKL was suppressed, while TRAIL was unexpectedly increased, suggesting binding of OPG to RANKL prior to TRAIL. We also demonstrate thatP. falciparumstimulates B cells to produce OPGin vitro, and that B cell OPG production is increasedex vivoin patients with falciparum, vivax and knowlesi malaria. Our findings provide further evidence of the importance of the OPG/RANKL/TRAIL pathway in pathogenesis of diseases involving systemic inflammation, and may have implications for adjunctive therapies. Further evaluation of the role of B cell production of OPG in host responses to malaria and other inflammatory diseases is warranted.
Spherically symmetric configurations in the quadratic
f(R)
gravity
Authors: Zhdanov V. I. , Stashko O. S. , Shtanov Yu. V. 
Published: July 2024

We study spherically symmetric configurations of the quadratic f(R) gravity [f(R)=R−R2/6μ2]. In the case of a purely gravitational system, we have fully investigated the global qualitative behavior of all static solutions satisfying the conditions of asymptotic flatness. These solutions are proved to be regular everywhere except for a naked singularity at the center; they are uniquely determined by the total mass M and the “scalar charge” Q characterizing the strength of the scalaron field at spatial infinity. The case Q=0 yields the Schwarzschild solution, but an arbitrarily small Q≠0 leads to the appearance of a central naked singularity having a significant effect on the neighboring region, even when the space-time metric in the outer region is practically insensitive to the scalaron field. Approximation procedures are developed to derive asymptotic relations near the naked singularity and at spatial infinity, and the leading terms of the solutions are presented. We have investigated the linear stability of the static solutions with respect to radial perturbations satisfying the null Dirichlet boundary condition at the center and numerically estimate the range of parameters corresponding to stable/unstable configurations. In particular, the configurations with sufficiently small Q turn out to be linearly unstable.

Published by the American Physical Society
2024
Chinese students in the global south: a case study of mobility to Chile
Authors: Bórquez Basáez Andrés , Morales Valdés José Manuel , Guzmán Núñez Osvaldo 
Published: July 2024

PurposeThe following article Chinese students' migration projects to the global south. Little work has sought to deepen the understanding of Chinese students' mobility to developing countries. This is key to determining a more complete profile of Chinese students and whether they fit into the categories of foreign students described by mainstream literature.Design/methodology/approachIn order to understand the respective experiences and points of view of foreign students in on the process of choosing the country of study, we proceeded to identify different students of Chinese origin who have made their trip to Chile during the last decade. In addition, documents on China's international student mobility policy were reviewed, mainly focusing on documents dealing with Chinese students going abroad.FindingsChinese students are increasingly looking to travel to countries in the Global South as an opportunity to differentiate themselves. Chile emerges as an attractive destination as it is seen as a stable country in Latin America. It is a place where China has several strategic interests that may allow future professional development.Originality/valueThis article focuses on this aspect, mainly on how Chinese students perceive Chile as a place to pursue higher education. There is strong evidence of Chinese student flows to developed countries, but there are still insufficient studies on South-South mobility.
3D bioprinted meat: the values-beliefs-norms evaluation of perceived future food source among younger generations
Authors: Ong Ardvin Kester S. , Arriola Raphael Sebastian L. , Eneria Zhyra Michaella R. , Lopez Lerryzel G. , Matias Erela Agatha L. , Diaz John Francis T. , German Josephine D. , Gumasing Ma. Janice J. 
Published: July 2024

PurposeThe acceptance and perception of people regarding 3D bioprinted meat are considered as primary concerns but have not been widely evaluated. This study aimed to determine how biospheric, altruistic, egoistic, ecological worldviews, awareness of consequences, social norms and personal norms affect the consumption intention of 3D bioprinted meat as a future food source.Design/methodology/approachThe values-beliefs-norms theory grounded this study. An online survey was conducted with 600 valid respondents for analysis utilizing the structural equation modeling method.FindingsIt was found that the ecological worldview had the highest significance, and biospheric and egoistic values positively impacted individuals’ ecological worldview. The awareness of consequences and social norms was also seen to directly influence personal norms, leading to consumption intention. However, it was determined that altruistic values toward an ecological worldview had no significant effect, as an individual's moral values are not affected by other people's well-being.Practical implicationsThis study was able to assess and discover the positive consumption intention among Filipinos, highlighting societal norms and pro-environmental behavior. The findings may help manufacturers market 3D bioprinted meat effectively and aid studies on environmentalism, social movements and consumer behavior, leading to acceptance of the development and proliferation of cultured meats.Originality/valueThere have been no studies on cultured meats such as 3D bioprinted meat in the Philippines. The current study was able to fully assess the pro-environmental behavior among Filipinos and intention for 3D bioprinted meat against the generic behavioral assessment among related studies. Comparison was presented based on the findings.
The role of employees in continuous improvement: a study on employee participation
Authors: Yang Ying , Yang Biao , Onofrei George , Nguyen Hung , Hlaciuc Elena 
Published: July 2024

Purpose
This study aims to delve into the mechanisms through which managers can enhance employee participation effectively.

Design/methodology/approach
This study adopts the Motivation-Opportunity-Ability (MOA) framework to identify the interrelationships among various drivers. Different levels of Continuous Improvement (CI) maturity were also considered to assess the effectiveness of these drivers on employee participation. An in-depth case study was conducted, involving the selection of four business units from a multinational manufacturer in Germany to represent varying levels of CI maturity.

Findings
This study uncovered intermediary variables that mediate the impact of drivers on the high-level MOA variables. It also revealed how the effectiveness of these drivers varies across different levels of CI maturity.

Originality/value
While different facets of CI have been scrutinized, the importance of employee participation stands out as pivotal for achieving enduring and meaningful progress. Despite this recognition, many business organizations continue to grasp with the challenge of motivating their employees to actively engage in CI initiatives. This study extends the applicability of the MOA framework and enriches the CI literature by offering deeper insights into the behavioural perspectives of employees. In practical terms, the findings of this study provide valuable guidance to decision-makers and HR department on staff training and development, enabling them to formulate more effective strategies aimed at fostering and augmenting employee participation in CI endeavours.
From mindset to market: unveiling the nexus of cognition, behavior and environment in igniting students’ E-entrepreneurial intentions
Authors: Chaudhary Manisha , Biswas Abhijeet 
Published: July 2024

PurposeIndia has witnessed a significant surge in internet users in recent years, creating an ideal environment for E-entrepreneurship. With the rise of E-commerce and the growth of the digital economy, there is tremendous potential for online businesses in developing nations. Our study outlines the behavioral, cognitive, and environmental aspects shaping students' E-entrepreneurial intentions (EEI).Design/methodology/approachOur study incorporated structural equation modeling (SEM), social cognitive theory (SCT), and entrepreneurial event model (EEM) to evaluate the EEI of 460 students from India's top five engineering institutes. The direct and indirect linkages in the model were examined by employing mediation and moderation analysis.FindingsOur findings reveal that behavioral, environmental, and cognitive factors facilitate evaluating feasibility, further igniting students' EEI. The cognitive factors and E-entrepreneurial feasibility (EEF) mediate the relationship between the underlying constructs. Furthermore, financial resource availability (FRA) strengthens, and loss aversion bias(LAB) weakens the linkage between EEF and EEM.Research limitations/implicationsThe study's findings may benefit online innovation communities, potential technopreneurs, financial institutions, and policymakers in improving the entrepreneurial ecosystem.Originality/valueThe study integrates psychological and sociological perspectives to understand the key facilitators of EEF and EEI. The study combines SCT and the EEM by appending crucial constructs such as FRA and LAB to broaden the horizons of EEI.