bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perspective of strategic plasma therapy for prognostic improvement of patients with ovarian cancer
Authors: Kajiyama Hiroaki , Utsumi Fumi , Nakamura Kae , Tanaka Hiromasa , Hori Masaru , Kikkawa Fumitaka 
Published: December 2013

ABSTRACTEpithelial ovarian carcinoma (EOC) is the leading cause of cancer-related death in women in Western countries. Once patients experience recurrence, complete cure is almost impossible. We elucidated the effect of nonequilibrium atmospheric pressure plasma on the growth of EOC, particularly in plasma-activated medium (PAM). Furthermore, we examined the role of reactive oxygen species (ROS) or their scavengers in chronic antineoplastic-resistant EOC cells. As a result, we showed PAM induced the antitumor effect of EOC cells in vitro and in vivo, even in chemoresistant cells. To apply the plasma treatment for advanced or recurrent EOC, we suggest adopting indirect plasma therapy instead of direct plasma considering intraperitoneal administration in the future. However, there are several problems under investigation, including intracellular mechanism of antitumor effect by PAM and adverse event in vivo.
Understanding Personal Mobile Technologies: Decomposing and De-Averaging the Value of a Smartphone
Authors: Arbore Alessandro , Graziani Rebecca , Venturini Sergio 
Published: December 2013

ABSTRACT
The study focuses on the multifaceted motives for adopting personal technologies. Specifically, it uses earlier models of technology adoption to develop a model of smartphone acceptance. The model is unique in that it decomposes attitudinal beliefs into three components: functional value, hedonic value, and symbolic value. Latent class analysis facilitates the identification of three user types. The analysis shows that value drivers, control beliefs, and normative beliefs play different roles for determining smartphone acceptance, depending on three different individual characteristics (i.e., playfulness, public self-consciousness, and innovativeness). The paper makes a contribution to the information systems literature by providing an analysis of the drivers of overall value perceptions for multipurpose information appliances and of the role of individual differences among potential users in forming these attitudes.
Influence of Chemical Degradation on the Surface Properties of Nano Restorative Materials
Authors: de Paula AB , de Fúcio SBP , Alonso RCB , Ambrosano GMB , Puppin-Rontani RM 
Published: December 2013

SUMMARY

Objectives
The aim of this in vitro study was to investigate the effect of chemical degradation on the surface roughness (Ra) and hardness (Knoop hardness number [KHN]) of nano restorative materials.

Methods
Disc-shaped specimens (5-mm diameter; 2-mm thick) of Filtek Z350 and TPH Spectrum composites and the Vitremer and Ketac Nano light-curing glass ionomer cements were prepared according to the manufacturers' instructions. After 24 hours, polishing procedures were performed and initial measurements of Ra and KHN were taken. The specimens were divided into 12 groups (n=10) according to material and storage media: artificial saliva, orange juice, and Coca-Cola. After 30 days of storage, the specimens were reevaluated for Ra and KHN. The pH values of the storage media were measured weekly. Data were tested for significant differences by repeated-measures three-way analysis of variance and Tukey tests (p&lt;0.05).

Results
Composites were found to present lower roughness values and higher hardness values than the ionomeric materials under all storage conditions. After degradation, the KHN of all experimental samples decreased significantly, while the Ra of the ionomeric materials increased, depending on the media, with a markedly negative impact of Coca-Cola and orange juice. There was no difference among the storage media for Filtek Z350 with regard to the KHN values. Nanofillers did not show any influence on the roughness and hardness of resin-modified glass ionomer cements and resin composites concerning their degradation resistance.
Purification and anticonvulsant activity of xanthotoxin (8-methoxypsoralen)
Authors: Skalicka-Woźniak Krystyna , Zagaja Mirosław , Głowniak Kazimierz , Łuszczki Jarogniew 
Published: December 2013

AbstractThe aim of the present study was to determine the anticonvulsant effects of xanthotoxin (8-methoxypsoralen) isolated from the fruit of Pastinaca sativa L. This plant is used in European traditional medicine, including Poland. For this purpose, high-performance counter-current chromatography was used. Different solvent systems, mixtures of n-heptane, ethyl acetate, methanol and water were tested in order to calculate partition coefficients. Finally, a mixture with the ratio of 1:1:1:1 (v/v/v/v), giving the K value = 0.92, was chosen as optimal. A rapid scale-up process from analytical to preparative was developed. Evaluation of the anticonvulsant action of xanthotoxin in the mouse maximal electroshock-induced seizure test revealed that it produced a clear-cut anticonvulsant action in mice, and the experimentally-derived median effective doses (ED50 values) ranged between 219 and 252 mg kg−1.
Detection of a novel mutation in exon 20 of the BRCA1 gene
Authors: Chakraborty Abhijit , Katarkar Atul , Chaudhuri Keya , Mukhopadhyay Ashis , Basak Jayasri 
Published: December 2013

AbstractHereditary breast cancer constitutes 5–10% of all breast cancer cases. Inherited mutations in the BRCA1 and BRCA2 tumor-suppressor genes account for the majority of hereditary breast cancer cases. The BRCA1 C-terminal region (BRCT) has a functional duplicated globular domain, which helps with DNA damage repair and cell cycle checkpoint protein control. More than 100 distinct BRCA1 missense variants with structural and functional effects have been documented within the BRCT domain. Interpreting the results of mutation screening of tumor-suppressor genes that can have high-risk susceptibility mutations is increasingly important in clinical practice. This study includes a novel mutation, p.His1746 Pro (c.5237A>C), which was found in BRCA1 exon 20 of a breast cancer patient. In silico analysis suggests that this mutation could alter the stability and orientation of the BRCT domain and the differential binding of the BACH1 substrate.
Characterization of ICRISAT Peanut Mini-Core Accessions with Regards to a Molecular Marker Associated with Resistance to Sclerotinia Blight
Authors: Chamberlin K. D. 
Published: December 2013

ABSTRACT
Cultivated peanut, the second most economically important legume crop throughout the United States and the third most important oilseed in the world, is consistently threatened by various diseases and pests. Sclerotinia minor Jagger (S. minor), the causal agent of Sclerotinia blight, is a major threat to peanut production in the Southwestern U.S., Virginia, and North Carolina and can reduce yield by up to 50% in severely infested fields. Although host plant resistance would provide the most effective solution to managing Sclerotinia blight, limited sources of resistance to the disease are available for use in breeding programs. Peanut germplasm collections are available for exploration and identification of new sources of resistance, but traditionally the process is lengthy, requiring years of field testing before those potential sources can be identified. Molecular markers associated with phenotypic traits can speed up the screening of germplasm accessions. The objective of this study was to characterize the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT) mini-core collection with regards to a molecular marker associated with Sclerotinia blight resistance. One hundred twenty-four (124) accessions from the collection were available and genotyped using the SSR marker and 67 were identified as potential new sources of resistance and targeted for further evaluation in field tests for Sclerotinia blight resistance.
Progress and controversies: Radiation therapy for invasive breast cancer
Authors: Jagsi Reshma 
Published: December 2013

Answer questions and earn CME/CNERadiation therapy is a critical component of the multidisciplinary management of invasive breast cancer. In appropriately selected patients, radiation not only improves local control, sparing patients the morbidity and distress of local recurrence, but it also improves survival by preventing seeding and reseeding of distant metastases from persistent reservoirs of locoregional disease. In recent years, considerable progress has been made toward improving our ability to select patients most likely to benefit from radiotherapy and to administer treatment in ways that maximize clinical benefit while minimizing toxicity and burden. This article reviews the role of radiation therapy in invasive breast cancer management, both after breast‐conserving surgery and after mastectomy. It focuses particularly on emerging evidence that helps to define the clinical situations in which radiotherapy is indicated, the appropriate targets of treatment, and optimal approaches for minimizing both the toxicity and the burden of treatment, all in the context of the evolving surgical and systemic management of this common disease. It includes a discussion of new approaches in breast cancer radiotherapy, including hypofractionation and intensity modulation, as well as a discussion of promising avenues for future research. CA Cancer J Clin 2014;64:135–152. © 2013 American Cancer Society.
Saint-Philibert de Tournus. L'œuvre du second maître, la galilée et la nef
Authors: Henriet Jacques 
Published: December 2013

Saint- Philibert de Tournus. L 'œuvre du second Maître : la galilée et la nef.
Après avoir retracé dans un précédent article (Bulletin monumental, 1990, III), les principales étapes de l'histoire de l'abbaye et montré que le chevet de Saint-Philibert (crypte, premier niveau du chœur et de l'abside et déambulatoire) avait été construit aussitôt après l'incendie de 1007-1008, l'auteur étudie l'œuvre de l'architecte qui a conçu le parti de la galilée et de la nef, parti dont il souligne la cohérence. Il fait à cette occasion le point sur les connaissances dont nous disposons sur les autres galilées bourguignonnes du XIe siècle. L'analyse des éléments essentiels de la structure de la galilée et de la nef de Saint-Philibert l'amène, par comparaison avec les réalisations de la première moitié du XIe siècle dans le domaine des supports et des voûtes, à proposer la date de circa 1035 pour le début de la construction de la galilée. L'ensemble des parties occidentales aurait été achevé vers 1055, à l'exception du voûtement du haut vaisseau de la nef, voûtement qui, toutefois avait probablement été envisagé par l'architecte dès l'origine.
Upregulation of ANK Protein Expression in Joint Tissue in Calcium Pyrophosphate Dihydrate Crystal Deposition Disease
Authors: Uzuki Miwa , Sawai Takashi , Ryan Lawrence M. , Rosenthal Ann K. , Masuda Ikuko 
Published: December 2013

Objective.Accumulation of excess extracellular inorganic pyrophosphate leads to calcium pyrophosphate dihydrate (CPPD) crystal formation in articular cartilage. CPPD crystal formation occurs near morphologically abnormal chondrocytes resembling hypertrophic chondrocytes. The ANK protein was recently implicated as an important factor in the transport of intracellular inorganic pyrophosphate across the cell membrane. We characterized ANK in joint tissues from patients with and without CPPD deposition and correlated the presence of ANK with markers of chondrocyte hypertrophy.Methods.Articular tissues were obtained from 24 patients with CPPD crystal deposition disease, 11 patients with osteoarthritis (OA) without crystals, and 6 controls. We determined the number of ANK–positive cells in joint tissues using immunohistochemistry andin situhybridization, and correlated ANK positivity with markers of chondrocyte hypertrophy including Runx2, type X collagen, osteopontin (OPN), and osteocalcin (OCN).Results.ANK was detected in synoviocytes, chondrocytes, osteoblasts, and osteocytes. ANK was seen extracellularly only in the matrix of cartilage and meniscus. The number of ANK-positive cells was significantly higher in CPPD than in OA or normal joint tissues. The amount and intensity of ANK immunoreactivity reached maximum levels in the large chondrocytes around crystal deposits. ANK was similarly distributed to and significantly correlated with Runx2, type X collagen, OPN, and OCN.Conclusion.ANK levels were higher in articular tissues from patients with CPPD deposition. ANK was concentrated around crystal deposits and correlated with markers of chondrocyte hypertrophy. These findings support a role for ANK in CPPD crystal formation in cartilage.
Does Clinically Important Change in Function After Knee Replacement Guarantee Good Absolute Function? The Multicenter Osteoarthritis Study
Authors: Maxwell Jessica L. , Felson David T. , Niu Jingbo , Wise Barton , Nevitt Michael C. , Singh Jasvinder A. , Frey-Law Laura , Neogi Tuhina 
Published: December 2013

Objective.Poor functional outcomes post–knee replacement are common, but estimates of its prevalence vary, likely in part because of differences in methods used to assess function. The agreement between improvement in function and absolute good levels of function after knee replacement has not been evaluated. We evaluated the attainment of improvement in function and absolute good function after total knee replacement (TKR) and the agreement between these measures.Methods.Using data from The Multicenter Osteoarthritis (MOST) Study, we determined the prevalence of achieving a minimal clinically important improvement (MCII, ≥ 14.2/68 point improvement) and Patient Acceptable Symptom State (PASS, ≤ 22/68 post-TKR score) on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Physical Function subscale at least 6 months after knee replacement. We also assessed the frequency of co-occurrence of the 2 outcomes, and the prevalence according to pre-knee replacement functional status.Results.We included 228 subjects who had a knee replacement during followup (mean age 65 yrs, mean body mass index 33.4, 73% female). Seventy-one percent attained the PASS for function after knee replacement, while only 44% attained the MCII. Of the subjects who met the MCII, 93% also attained the PASS; however, of subjects who did not meet the MCII, 54% still achieved a PASS. Baseline functional status was associated with attainment of each MCII and PASS.Conclusion.There was only partial overlap between attainment of a good level of function and actually improving by an acceptable amount. Subjects were more likely to attain an acceptable level of function than to achieve a clinically important amount of improvement post–knee replacement.
Sleep Problems in Patients with Rheumatoid Arthritis
Authors: Westhovens René , Van der Elst Kristien , Matthys Ann , Tran Michelle , Gilloteau Isabelle 
Published: December 2013

Objective.To investigate sleep problems, and the relationship between sleep and disease activity, in Belgian patients with established rheumatoid arthritis (RA).Methods.This cross-sectional, observational, multicenter study assessed sleep quality using the Athens Insomnia Scale (AIS) and Pittsburgh Sleep Quality Index (PSQI), and daytime sleepiness using the Epworth Sleepiness Scale (ESS). Additional patient-reported outcomes included visual analog scales (VAS) for fatigue and pain, the Medical Outcomes Study Short Form-36 Health Survey, the Health Assessment Questionnaire-Disability Index (HAQ-DI), and the Positive and Negative Affect Schedule. Multivariate regression and structural equation modeling identified factors associated with sleep quality, with the 28-joint Disease Activity Score [DAS28-C-reactive protein (CRP)] as a continuous or categorical variable. Analyses were performed on the total population and on patients stratified by disease activity status: remission/low (DAS28-CRP ≤ 3.2) or moderate to high (DAS28-CRP > 3.2).Results.Among 305 patients, mean (SD) age was 57.00 (12.38) years and mean (SD) disease duration was 11.77 (9.94) years. Mean (SD) AIS, PSQI, and ESS scores were 6.8 (4.79), 7.8 (4.30), and 7.3 (4.67), respectively. Mean (SD) VAS fatigue, VAS pain, and HAQ-DI were 45.22 (26.29), 39.04 (26.21), and 1.08 (0.75), respectively. There were significant positive relationships between DAS28-CRP and AIS/PSQI, but a significant negative relationship between DAS28-CRP and ESS. Several potentially confounding factors were identified.Conclusions.Poor control of RA is associated with a reduction in sleep quality and decreased daytime sleepiness, which is likely explained by pain-related alertness. Future prospective studies are needed to confirm potential relationships between sleep quality, sleepiness, and RA treatment.
Variability in Recommendations for Total Knee Arthroplasty Among Rheumatologists and Orthopedic Surgeons
Authors: Fraenkel Liana , Suter Lisa , Weis Lawrence , Hawker Gillian A. 
Published: December 2013

Objective.The most rapidly growing population of patients undergoing total knee arthroplasty (TKA) is under the age of 65. The objective of our study was to gain insight into the factors influencing physicians’ recommendations for persons in this age group with moderate osteoarthritis (OA).Methods.Rheumatologists and orthopedic surgeons attending national meetings were asked to complete a survey including a standardized scenario of a 62-year-old person with knee OA who has moderate knee pain limiting strenuous activity despite medical management. We used an experimental 2 × 2 × 2 design to examine the effects of sex, employment status, and severity of radiographic OA on physicians’ recommendations. Each physician was asked to rate a single scenario.Results.The percentage of physicians recommending TKA varied from 30% to 55% for scenarios describing a patient with mild radiographic OA, and from 39% to 71% for scenarios describing a patient with moderate radiographic OA. Surgeons were less likely to recommend TKA for women compared to men of the same age, employment status, symptom severity, and functional status, and radiographs. Rheumatologists practicing in academic settings were more likely to recommend TKA compared to those practicing in nonacademic settings, and American surgeons were more likely to recommend TKA compared to their European counterparts.Conclusion.Orthopedic surgeons and rheumatologists vary significantly in their recommendations for patients with moderate knee pain and functional limitations. Both patient and physician characteristics influence physicians’ recommendations, and rheumatologists and orthopedic surgeons display different patterns of decision making.
Impulsivité et difficultés de régulation émotionnelle et de gestion des relations sociales chez l'enfant et l'adolescent
Authors: Gomez Jean-Marc , Van der Linden Martial 
Published: December 2013

Résumé L’impulsivité constitue un dénominateur commun à de nombreux états psychopathologiques et comportements problématiques. Le but du présent article est de décrire l’approche multidimensionnelle de l’impulsivité proposée par Whiteside et Lynam (2001). Selon cette approche, l’impulsivité peut être scindée en quatre facettes distinctes : l’urgence, le manque de préméditation, le manque de persévérance et la recherche de sensations. Par ailleurs, nous suggérons également que ces différentes facettes sont associées à des mécanismes cognitifs, émotionnels et motivationnels spécifiques. Enfin, nous décrirons des études récentes qui montrent en quoi cette conception de l’impulsivité en quatre dimensions peut contribuer à une meilleure compréhension des problèmes d’autorégulation chez l’enfant et l’adolescent.
Le développement du raisonnement dans la résolution de problèmes : l'apport de la théorie des modèles mentaux
Authors: Thevenot Catherine , Perret Patrick 
Published: December 2013

Résumé La première partie de cet article est dédiée à la présentation générale d’une des théories du raisonnement humain aujourd’hui les plus influentes : la Théorie des Modèles Mentaux (Johnson-Laird, 1983). Le champ couvert par cette théorie a été étendu à de nombreux domaines comme la compréhension de textes ou la prise de décision et, plus récemment, à la résolution de problèmes arithmétiques verbaux. Dans la seconde partie de l’article, nous recensons les élements de preuve empirique apportés à l’hypothèse que les adultes comme les enfants construisent des modèles mentaux lorsqu’ils sont engagés dans ce type d’activité. La théorie des modèles mentaux pourrait ainsi nous permettre de mieux comprendre les difficultés rencontrées par certains enfants dans la résolution de problèmes arithmétiques. Dans la dernière partie de l’article, ces implications plus cliniques sont envisagées.
La reconnaissance visuelle des objets chez l'enfant avec autisme : Résultats préliminaires à une adaptation pour enfants de la Birmingham Object Recognition Battery (BORB)
Authors: Gillet Patrice , Chabernaud Camille , Batty Magali , Barthélémy Catherine , Jambaqué Isabelle 
Published: December 2013

Résumé La reconnaissance visuelle des objets a été étudiée chez des enfants avec autisme à la BORB (Birmingham Object Recognition Battery) créée par Riddoch et Humphreys (1993) pour décrire les traitements impliqués dans l’identification visuelle des objets et leurs défaillances chez les adultes cérébrolésés. Huit tests de la BORB ont été adaptés pour les enfants et proposés à 8 enfants avec autisme appariés en âge mental à 8 enfants témoins. Les résultats obtenus montrent que les enfants avec autisme ont de meilleures performances que les enfants témoins aux tests d’analyse perceptive qui sollicitent l’encodage des primitives visuelles. Par contre, on ne note pas de différence significative entre les deux groupes aux tests qui sollicitent les traitements perceptifs intermédiaires de catégorisation perceptive et les traitements représentatifs de nature sémantique. Ces résultats préliminaires, obtenus sur de petits échantillons, sont discutés en référence à l’hypothèse de la « faible cohérence centrale » proposée dans la littérature pour rendre compte des particularités cognitives dans l’autisme, en soulignant également l’intérêt clinique de la BORB pour décrire les agnosies visuelles dans les pathologies neuropédiatriques.
L'orthographe lexicale
Authors: Siffrein-Blanc Julia , George Florence 
Published: December 2013

Résumé Dans le domaine de l’orthographe, de nombreuses études portent sur l’acquisition de l’orthographe lexicale ainsi que sur les liens entre son enrichissement et la lecture ; l’objectif de cette étude est d’apporter des pistes au niveau clinique dans la prise en charge des dyslexies-dysorthographies développementales. Nous présenterons dans ce cadre l’élaboration d’un protocole d’entraînement à l’orthographe lexicale avec l’hypothèse qu’une stimulation basée sur les stratégies visuo-sémantique, visuo-attentionnelle, probabiliste et morphologique permettrait une amélioration en lecture et en orthographe.