bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical predictors of neo‐osteogenesis in patients with chronic rhinosinusitis
Authors: Huang Zhenxiao , Hajjij Amal , Li Gang , Nayak Jayakar V. , Zhou Bing , Hwang Peter H. 
Published: February 2015

BackgroundNeo‐osteogenesis of the paranasal sinuses is a radiologic finding of unclear clinical significance. Although current evidence suggests that these bony changes represent an inflammatory response rather than an infectious osteitis, bacteria associated with the sinonasal mucosa may induce inflammatory mediators as a mechanism of neo‐osteogenesis. The objectives of this study were (1) to determine whether there is an association between bacteria isolated on sinus culture and neo‐osteogenesis, and (2) to identify other predictive factors for neo‐osteogenesis.MethodsNinety patients undergoing sinus surgery for medically refractory CRS were recruited. Radiologic evidence of neo‐osteogenesis was assessed by the Global Osteitis Scoring Scale (GOSS) and mucosal disease severity was assessed by the Lund‐Mackay score (LMS). Bacterial culture was obtained endoscopically at the preoperative office visit or during surgery. Multiple and logistic regression models were used to evaluate the association between the types of bacterial species isolated, number of previous surgeries, and severity of neo‐osteogenesis.ResultsThirty of the 90 (33.3%) patients had radiologic evidence of neo‐osteogenesis. Pseudomonas aeruginosa was significantly associated with neo‐osteogenesis (odds ratio [OR], 3.97; 95% confidence interval [CI], 1.12 to 13.56), whereas Staphylococcus aureus was not. The number of previous surgeries, especially 2 or more previous surgeries, was associated with the extent of neo‐osteogenesis (OR, 3.48; 95% CI, 1.14 to 10.51). The LMS was also significantly associated with the extent of neo‐osteogenesis.ConclusionThe presence of P. aeruginosa in the sinuses is an independent predictor of neo‐osteogenesis, whereas S. aureus is not. The number of previous surgeries and the LMS are also independently associated with the severity of neo‐osteogenesis.
Observer‐Based H∞ Control for Continuous‐Time Networked Control Systems
Authors: Wang Tian‐Bao , Wang Yu‐Long , Wang Heng , Zhang Jian 
Published: February 2015

AbstractThis paper is concerned with the observer‐based H∞ control for continuous‐time networked control systems (NCSs) considering packet dropouts and network‐induced delays. The packet dropouts and network‐induced delays in the sensor‐to‐controller (S‐C) channel and network‐induced delays in the controller‐to‐actuator (C‐A) channel are taken into full consideration. By taking the non‐uniform distribution characteristic of the arrival instants of actually adopted controller inputs into account, a new model for continuous‐time NCSs is established. To reduce the conservatism of modelling, a linear estimation‐based measurement output estimation method is introduced. Based on the newly established model and a Lyapunov functional, new controller design methods are proposed. A numerical example is given to illustrate the effectiveness and merits of the derived results.
Terminal innervation of female genitalia, cutaneous sensory receptors of the epithelium of the labia minora
Authors: Schober Justine , Aardsma Nathan , Mayoglou Lazarus , Pfaff Donald , Martín‐Alguacil Nieves 
Published: February 2015

IntroductionLittle information is available regarding the sensory nerve endings within the glabrous skin of the external female genitalia. The diversity of possible sensations suggests a variety of receptor types. Comprehensive knowledge of the sensory stimuli, including stimulus position, changes in temperature, pressure and pain, is critical for addressing pain and sexual function disorders clinically. The aim of this neuro‐histological study is document the presence and characteristics of cutaneous sensory receptors in female genital tissue.Materials and MethodsLabial skin samples were obtained from ten normal girls (aged 1–9 years). The specimens were waste tissue obtained during surgical intervention. They were all obtained by the senior investigator, a pediatric urologist, after the parent or legal guardian had given informed consent. The specimens were stained by Cajal‐type silver impregnation and by immunocytochemistry against protein gene product (PGP) 9.5 and neuron‐specific enolase (NSE).ResultsPGP 9.5 was the most sensitive neural marker for identifying cutaneous sensory receptors. Free nerve endings (FNEs) in the papillary dermis appeared as thin fibers, varicose, branched or single processed, straight or bent. In the labia minora, FNEs were identified in the strata basale, spinosum and granulosum of the epidermis. Non‐capsulated (Meissner‐like) corpuscles in the dermal papillae interdigitated with epidermal ridges of the skin. Capsulated corpuscles protruded from the deep dermis into the epidermis. Encapsulated corpuscles and cells located in the inner and outer cores were strongly positive for PGP 9.5.ConclusionsFNEs, Meissner's corpuscles and Pacinian corpuscles are present in the female labia minora and exhibit characteristic staining patterns. Clin. Anat. 28:392–398, 2015. © 2014 Wiley Periodicals, Inc.
PIK3CA mutations predict recurrence in localized microsatellite stable colon cancer
Authors: Manceau Gilles , Marisa Laetitia , Boige Valérie , Duval Alex , Gaub Marie‐Pierre , Milano Gérard , Selves Janick , Olschwang Sylviane , Jooste Valérie , le Legrain Michè , Lecorre Delphine , Guenot Dominique , Etienne‐Grimaldi Marie‐Christine , Kirzin Sylvain , Martin Laurent , Lepage Come , Bouvier Anne‐Marie , Laurent‐Puig Pierre 
Published: February 2015

AbstractPIK3CA, which encodes the p110α catalytic subunit of PI3Kα, is one of the most frequently altered oncogenes in colon cancer (CC), but its prognostic value is still a matter of debate. Few reports have addressed the association between PIK3CA mutations and survival and their results are controversial. In the present study, we aimed to clarify the prognostic impact of PIK3CA mutations in stage I–III CC according to mismatch repair status. Fresh frozen tissue samples from two independent cohorts with a total of 826 patients who underwent curative surgical resection of CC were analyzed for microsatellite instability and screened for activating point mutations in exon 9 and 20 of PIK3CA by direct sequencing. Overall, 693 tumors (84%) exhibited microsatellite stability (MSS) and 113 samples (14%) harbored PIK3CA mutation. In the retrospective training cohort (n = 433), patients with PIK3CA‐mutated MSS tumors (n = 47) experienced a significant increased 5‐year relapse‐free interval compared with PIK3CA wild‐type MSS tumors (n = 319) in univariate analysis (94% vs. 68%, Log‐rank P = 0. 0003) and in multivariate analysis (HR = 0.12; 95% confidence interval, 0.029–0.48; P = 0.0027). In the prospective validation cohort (n = 393), the favorable prognostic impact of PIK3CA mutations in MSS tumors (n = 327) was confirmed (83% vs. 67%, Log‐rank P = 0.04). Our study showed that PIK3CA mutations are associated with a good prognosis in patients with MSS stage I–III CC.
An Old Friend in a New Guise–Recent Trends in Homogeneous Transition Metal Catalysis
Authors: Behr Arno , Vorholt Andreas J. , Seidensticker Thomas 
Published: February 2015

AbstractThe present contribution surveys recent developments and trends in homogeneous transition metal catalysis (HTMC). Emphasis is on industrially relevant reactions, such as hydroformylations, carbonylations, hydrogenations, oxidations, aminations, metatheses, and related tandem reactions. Besides classical petrochemical feedstocks, transformations of renewable resources are also taken into account. Additionally, examples of homogeneous catalysis in continuously operated miniplants are disclosed.
The Edwards Valeo lifestents in the treatment and palliation of congenital heart disease in infants and small children
Authors: Butera Gianfranco , Giugno Luca , Basile Domenica , Piazza Luciane , Chessa Massimo , Carminati Mario 
Published: February 2015

BackgroundIntravascular stenting is the procedure of choice in the treatment of vascular stenoses. However, in infants and small children large sheaths are needed, and adult‐size stents cannot be implanted. The Valeo Biliary Lifestent (Edwards Lifesciences Irvine, CA) is low profile and can be dilated up to 18‐20 mm. We aimed to report on early and mid‐term results with the use of Valeo stents in infants and children with congenital heart disease.MethodsTwenty‐five subjects were treated in our experience. Mean age and weight were 39 ± 35 months (range 1–132) and 10.4 ± 6.7 kg (range 3–30), respectively. Two groups of patients were: Group A: patients with pulmonary artery stenosis (21 subjects); Group B subjects in whom stenting was applied in other vessel or heart sites (four subjects).ResultsA total of 35 stents were successfully used. Fluoroscopy time was 32 ± 11 min. No intra‐operative death or hospital mortality was recorded. Stent post dilatation was performed in nine patients. The incidence of complication was 12% (3/25) (two subjects developed transient hypotension and bradycardia which required inotropic treatment, 1 patient developed mild lung bleeding). There was a significant improvement of angiographic appearance and RV pressure (RV/AO systolic pressure ratio before 1 ± 02 (range 0.8–1.5) versus after the procedure 0.6 ± 0.2 (range 0.4–0.9) P < 0.001). In group B stents were successfully implanted in aortic recoarctation, interatrial septum and in two modified BT shunts. At a median follow‐up of 18 months (range 1–24 months) results remained stable and no complications occurred. In particular no stent fractures were seen. Furthermore, redilation was performed safely and successfully in three subjecs up to 18 months after the first implantation.ConclusionsIn our series, Valeo Lifestents have proven to be effective and with low incidence of complication in various anatomical settings, in low weight infants and in early post‐operative course. Large series and longer follow‐up are mandatory. © 2015 Wiley Periodicals, Inc.
Finding the elusive and causative autoantibody: An atypical case of autoimmune hemolytic anemia
Authors: Fetzko Stephanie , Ahmed Asra , Cooling Laura 
Published: February 2015

Key Clinical MessageAn isolated IgA‐mediated autoimmune hemolytic anemia can present a diagnostic challenge. When a routine direct antiglobulin test (DAT) is negative but clinical suspicion remains high, further testing with monospecific antisera should be performed. As with IgG‐mediated WAIHA, steroids are first‐line treatment, though splenectomy is often required to achieve a durable treatment response.
Nitrogen‐Doped Annealed Nanodiamonds with Varied sp2/sp3 Ratio as Metal‐Free Electrocatalyst for the Oxygen Reduction Reaction
Authors: Zhu Yansong , Lin Yangming , Zhang Bingsen , Rong Junfeng , Zong Baoning , Su Dang Sheng 
Published: February 2015

AbstractNitrogen‐doped nanocarbon materials as metal‐free electrocatalysts for the oxygen reduction reaction (ORR) have attracted great attention, owing to their catalytic activity close to Pt/C in alkaline media. Annealed nanodiamonds (AND) possess a special structure, because we can finely control the carbon sp2/sp3 ratio. This provides a good opportunity to study the relationship between ORR performance (activity and stability) and the special structure of AND. We have used nitrogen‐doped annealed nanodiamonds (NAND) with varied carbon sp2/sp3 ratio as metal‐free electrocatalysts for ORR in alkaline media. NAND showed higher catalytic activity for ORR with higher content of sp2 carbon and larger amount of nitrogen species present as pyridinic groups. More importantly, NAND displayed stability superior to other nitrogen‐doped nanocarbon materials as a result of transformation of carbon from sp3 to sp2 during electrochemical cycling.
Metallogels Self‐Assembled from Linear Rod‐Like Platinum Complexes: Influence of the Linkage
Authors: Chen Mingming , Wei Chengsha , Wu Xibo , Khan Majid , Huang Ningdong , Zhang Guobin , Li Liangbin 
Published: February 2015

AbstractTwo linear rod‐like platinum complexes, which only differed in the linkage, were prepared. They both self‐assemble into metallogels in nonpolar solvents; however, a very big contrast was observed. Unexpectedly, a much weaker gel was acquired upon replacing the ester linkage by an amide group. The intermolecular hydrogen bonding offered by the amide motif leads to a different stacking fashion and mechanism. The results demonstrated herein contribute to the rational design of metallogels as well as other functional supramolecular materials.
Hydrothermale Karbonisierung: 3. Kinetisches Modell
Authors: Kruse Andrea , Grandl Robert 
Published: February 2015

AbstractBasierend auf Experimenten im Mikroautoklaven wurde ein einfaches kinetisches Modell für die hydrothermale Karbonsierung entwickelt. Dieses Modell wurde zur Beschreibung der Umsetzung von zehn verschiedenen Biomassen mit unterschiedlichem Ligningehalt und mit guter Übereinstimmung zu gemessenen Daten eingesetzt. Dabei wurde angenommen, dass die Anwesenheit von Lignin den ersten Reaktionsschritt, die Hydrolyse von Biomasse, verlangsamt. Ein direkter Zusammenhang zwischen dem Ligningehalt und der geringeren Reaktionsgeschwindigkeit bei ligninhaltigen Biomassen konnte allerdings nicht hergestellt werden.
Global Existence of Smooth Solutions and Convergence to Barenblatt Solutions for the Physical Vacuum Free Boundary Problem of Compressible Euler Equations with Damping
Authors: Luo Tao , Zeng Huihui 
Published: February 2015

AbstractFor the physical vacuum free boundary problem with the sound speed being C1/2‐Hölder continuous near vacuum boundaries of the one‐dimensional compressible Euler equations with damping, the global existence of the smooth solution is proved, which is shown to converge to the Barenblatt self‐similar solution for the porous media equation with the same total mass when the initial datum is a small perturbation of the Barenblatt solution. The pointwise convergence with a rate of density, the convergence rate of velocity in the supremum norm, and the precise expanding rate of the physical vacuum boundaries are also given. The proof is based on a construction of higher‐order weighted functionals with both space and time weights capturing the behavior of solutions both near vacuum states and in large time, an introduction of a new ansatz, higher‐order nonlinear energy estimates, and elliptic estimates.© 2016 Wiley Periodicals, Inc.
A CD45‐based barcoding approach to multiplex mass‐cytometry (CyTOF)
Authors: Lai Liyun , Ong Raymond , Li Juntao , Albani Salvatore 
Published: February 2015

AbstractCyTOF enables the study of the immune system with a complexity, depth, and multidimensionality never achieved before. However, the full potential of using CyTOF can be limited by scarce cell samples. Barcoding strategies developed based on direct labeling of cells using maleimido‐monoamide‐DOTA (m‐DOTA) provide a very useful tool. However, using m‐DOTA has some inherent problems, mainly associated with signal intensity. This may be a source of uncertainty when samples are multiplexed. As an alternative or complementary approach to m‐DOTA, conjugating an antibody, specific for a membrane protein present on most immune cells, with different isotopes could address the issues of stability and signal intensity needed for effective barcoding. We chose for this purpose CD45, and designed experiments to address different types of cultures and the ability to detect extra‐ and intra‐cellular targets. We show here that our approach provides an useful alternative to m‐DOTA in terms of sensitivity, specificity, flexibility, and user‐friendliness. Our manuscript provides details to effectively barcode immune cells, overcoming limitations in current technology and enabling the use of CyTOF with scarce samples (for instance precious clinical samples). © 2015 The Authors. Published by Wiley Periodicals, Inc.
A scheme of access service recommendation for the Social Internet of Things
Authors: Chen Zhikui , Ling Ruochuan , Huang Chung‐Ming , Zhu Xu 
Published: February 2015

SummaryThe rapid increase in the complexity and the extent of personalization of services in the Internet of Things (IoT) has led to a greater demand for frequent collaboration among heterogeneous devices. Moreover, with the inseparable relations between human and devices, the paradigm of Social IoT (SIoT) is gaining popularity in recent years. How to effectively facilitate the access to quality services and credible devices in large‐scale networks via defining, establishing, and managing social architectures among things has become a critical issue. In this paper, a scheme of access service recommendation for the SIoT is presented with the understanding of inherent constraints and factors that influence the security and stability of IoT networks. In which, timeliness properties are considered in each transaction for dynamic performance enhancements. With the benefits of promoting service discovery and composition, social relationships among things are introduced in the proposed scheme. An energy‐aware mechanism is also utilized as a restrictive factor in trustworthiness evaluation. Finally, the recommendation is based not only on the past performance but also on the social relationship and the energy status of nodes. Simulation experiments demonstrate the effectiveness and benefits of our scheme from three aspects including rating accuracy, dynamic behavior, and network stability. Copyright © 2015 John Wiley & Sons, Ltd.
Self‐determination theory, social media and charitable causes: An in‐depth analysis of autonomous motivation
Authors: Ferguson Ronald , Gutberg Jennifer , Schattke Kaspar , Paulin Michèle , Jost Nina 
Published: February 2015

AbstractUsing the framework of the self‐determination theory continuum, we investigated the influence of the distinct autonomous and controlled motivational regulations for engaging participants in online and offline support of charitable events for the causes of breast cancer and homeless youth. Participants were exposed online to Facebook event pages appealing to helping others. When the often omitted integrated autonomous regulation was included in the model, it was the strongest predictor of supportive intentions. Without integrated regulation in the model, we would have overestimated the relatively minor influence of controlled introjected regulation. Furthermore, rather than one overall measure of autonomous intrinsic regulation, we assessed the differential influences of three separate dimensions (to experience stimulation, to learn and to accomplish). Intrinsic motivation to experience stimulation had a unique influence on online and offline supportive intentions. Such was not the case for the dimensions of to learn or to accomplish. Follow‐up meditation analyses of self‐reported behaviours confirmed that autonomous integrated and intrinsic to experience stimulation regulations led to stronger intentions to support online behaviours, which, in turn, increased the likelihood of actual online engagement. The findings in a social media context highlight the importance of analysing distinct regulatory styles within the self‐determination theory continuum. Copyright © 2015 John Wiley & Sons, Ltd.
Origin of Low Detection Limit and High Selectivity of Roche Accu‐Chek Test Strips that Enables Measurement of Tear Glucose Levels
Authors: Cha Kyoung Ha , Qin Yu , Meyerhoff Mark E. 
Published: February 2015

AbstractTear glucose measurements have been suggested as a potential alternative to blood glucose monitoring for diabetic patients. While previous work has reported a correlation between blood and tear glucose levels in humans, this link has not been thoroughly established and additional clinical studies are needed. We recently reported that Roche’s electrochemical Accu‐Chek blood glucose test strips exhibit far superior analytical performance over other commercial brands, with the low detection limit and high selectivity required for quantitating tear glucose levels. Herein, we evaluate the origin of the high sensitivity and selectivity of the Roche test strips and show that the use of pyrroloquinoline quinone (PQQ)‐dependent glucose dehydrogenase (GDH) as an active enzyme reagent in combination with a nitrosoaniline derivative as an electron transfer mediator are primarily responsible for the low limit of quantification (LOQ) (ca. 9 µM) and enhanced selectivity achieved with these strips.
Model for understanding consumer textural food choice
Authors: Jeltema Melissa , Beckley Jacqueline , Vahalik Jennifer 
Published: February 2015

AbstractThe current paradigm for developing products that will match the marketing messaging is flawed because the drivers of product choice and satisfaction based on texture are misunderstood. Qualitative research across 10 years has led to the thesis explored in this research that individuals have a preferred way to manipulate food in their mouths (i.e., mouth behavior) and that this behavior is a major driver of food choice, satisfaction, and the desire to repurchase. Texture, which is currently thought to be a major driver of product choice, is a secondary factor, and is important only in that it supports the primary driver—mouth behavior. A model for mouth behavior is proposed and the qualitative research supporting the identification of different mouth behaviors is presented. The development of a trademarked typing tool for characterizing mouth behavior is described along with quantitative substantiation of the tool's ability to group individuals by mouth behavior. The use of these four groups to understand textural preferences and the implications for a variety of areas including product design and weight management are explored.
Effects of the roots ofCynodon dactylonandSchefflera heptaphyllaon water infiltration rate and soil hydraulic conductivity
Authors: Leung A. K. , Garg A. , Coo J. L. , Ng C. W. W. , Hau B. C. H. 
Published: February 2015

AbstractWater infiltration rate and hydraulic conductivity in vegetated soil are two vital hydrological parameters for agriculturists to determine availability of soil moisture for assessing crop growths and yields, and also for engineers to carry out stability calculations of vegetated slopes. However, any effects of roots on these two parameters are not well‐understood. This study aims to quantify the effects of a grass species,Cynodon dactylon, and a tree species,Schefflera heptaphylla, on infiltration rate and hydraulic conductivity in relation to their root characteristics and suction responses. The two selected species are commonly used for ecological restoration and rehabilitation in many parts of the world and South China, respectively. A series ofin‐situdouble‐ring infiltration tests was conducted during a wet summer, while the responses of soil suction were monitored by tensiometers. When compared to bare soil, the vegetated soil has lower infiltration rate and hydraulic conductivity. This results in at least 50% higher suction retained in the vegetated soil. It is revealed that the effects of root‐water uptake by the selected species on suction were insignificant because of the small evapotranspiration (<0.2 mm) when the tests were conducted under the wet climate. There appears to have no significant difference (less than 10%) of infiltration rates, hydraulic conductivity and suction retained between the grass‐covered and the tree‐covered soil. However, the grass and tree species having deeper root depth and greater Root Area Index (RAI) retained higher suction. Copyright © 2015 John Wiley & Sons, Ltd.