bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linkages between Large-Scale Climate Patterns and Karst Spring Discharge in Northern China
Authors: Huo Xueli , Liu Zhongfang , Duan Qingyun , Hao Pengmei , Zhang Yanyan , Hao Yonghong , Zhan Hongbin 
Published: October 2015

Abstract
The Niangziguan Springs (NS) discharge is used as a proxy indicator of the variability of the karst groundwater system in relation to major climate indices such as El Niño–Southern Oscillation (ENSO), Pacific decadal oscillation (PDO), Indian summer monsoon (ISM), and west North Pacific monsoon (WNPM). The relationships between spring discharge and these climate indices are determined using the multitaper method (MTM), continuous wavelet transform (CWT), and wavelet transform coherence (WTC). Significant periodic components of spring discharge in the 1-, 3.4-, and 26.8-yr periodicities are identified and reconstructed for further investigation of the correlation between spring discharge and large-scale climate patterns on these time scales. Correlation coefficients and WTC between spring discharge and the climate indices indicate that variability in spring discharge is significantly and positively correlated with monsoon indices in the 1-yr periodicity and negatively correlated with ENSO in the 3.4-yr periodicity and PDO in the 26.8-yr periodicity. This suggests that the oscillations of the spring discharge on annual, interannual, and interdecadal time scales are dominated by monsoon, ENSO, and PDO in the NS basin, respectively. Results show that monsoons modulate the spring discharge by affecting local meteorological parameters. ENSO and PDO impact the variability of the NS discharge by affecting the climate conditions in northern China.
Cognitive neuropsychological functioning in New Zealand Māori diagnosed with schizophrenia
Authors: Kake Tai R , Garrett Nicholas , Te Aonui Menetta 
Published: October 2015

Objective: Previous research suggests that New Zealand Māori may have an elevated rate of schizophrenia. However, there is limited evidence on important clinical features of the illness in this population. This study examined cognitive neuropsychological functioning in 54 adult Māori diagnosed with schizophrenia and 56 Māori controls. This study also examined associations between cognition, medication and symptoms of psychosis in the schizophrenia group. Method: The groups were matched on socio-demographic variables, handedness and premorbid cognitive ability. Participants were assessed on neuropsychological tests of attention, executive ability, motor, premorbid ability, verbal/non-verbal memory and verbal fluency (English/Māori versions). The Positive and Negative Syndrome Scale was used to assess psychotic symptoms. Information on cultural identity, duration of illness, duration of untreated psychosis, medication and substance abuse was collected. Results: The performance of the schizophrenia group was significantly lower than the control group on all the neuropsychological tests, except the test of attention. The effect sizes were moderate to large: 0.78 for motor function; 1.3 for executive ability, verbal fluency and visual memory; 1.6 for verbal learning and 1.8 for verbal memory. These differences remained after adjustment for multiple comparisons and covariates. A higher dose of antipsychotic medication and a higher anticholinergic load were associated with greater verbal memory impairment ( r = −0.38 and r = −0.38, respectively). A longer duration of illness was associated with greater impairment of verbal memory (rho = −0.48), verbal learning (rho = −0.41) and visual memory (rho = −0.44). Conclusion: The findings for the schizophrenia group show a profile of generalised cognitive impairment with greater impairment of verbal memory. The cognitive impairment in this group was independent of psychotic symptoms, but was associated with a higher antipsychotic dose, higher anticholinergic load and longer duration of illness. These findings have implications for clinical prescribing practices and rehabilitation for New Zealand Māori diagnosed with schizophrenia.
Additional postoperative cell salvage of shed mediastinal blood in cardiac surgery does not reduce allogeneic blood transfusions: a cohort study
Authors: Vermeijden Wytze J , Hagenaars Johanna AM , Scheeren Thomas WL , de Vries Adrianus J 
Published: October 2015

Objectives: Does additional postoperative collection and processing of mediastinal shed blood with a cell salvage device reduce the number of allogeneic blood transfusions compared to intraoperative cell salvage alone? Methods: A single-centre cohort study in which adult patients with coronary artery bypass grafting or aortic valve replacement were allocated to either a C.A.T.S® group with intraoperative blood processing only or a CardioPat® group with both intra- and postoperative blood processing. The primary endpoint was the number of allogeneic blood transfusions during hospital admission. Results: The study included 99 patients; 50 in the C.A.T.S® and 49 in the CardioPat® group. There was no difference in the number of red blood cells (RBC) (C.A.T.S® group 43 units versus CardioPat® 50 units, p=0.74), fresh frozen plasma (C.A.T.S® 8 units versus CardioPat® 8 units, p=1.00) or platelets (C.A.T.S® 5 units versus CardioPat® 4 units, p=1.00) transfused during the hospital stay. Cardiac creatinine kinase (CK-MB) and troponin levels did not differ between the groups although a significant time effect (p<0.001) was present. Creatinine kinase (CK) levels were not different between the groups three hours after arrival in the intensive care unit (ICU) (CardioPat® group versus C.A.T.S® group, p=0.17). But, compared to the C.A.T.S® group on the first (350 [232-469] IU/L) and second postoperative days (325 [201-480] IU/L), the increase in CK levels was more in the CardioPat® group on the first (431 [286-642] IU/L, p=0.02) and second postoperative days (406 [239-760] IU/L, p=0.05), resulting in a difference between the groups (p=0.04) Conclusions: Postoperative cell salvage does not reduce transfusion requirements compared to intraoperative cell salvage alone, but results in elevated total CK levels that suggest haemolysis.
The importance of the feasibility study: Lessons from a study of the hand-held fan used to relieve dyspnea in people who are breathless at rest
Authors: Booth Sara , Galbraith Sarah , Ryan Richella , Parker Richard A , Johnson Miriam 
Published: October 2015

Background: The dyspnea accompanying advanced cardiorespiratory disease is often refractory to palliation. It is disabling, distressing and associated with the diseases most common everywhere in the world. The hand-held fan, used to generate a draught across the face, is a simple, cost-effective, safe, and universally applicable palliative breathlessness intervention, consistently described as valuable in qualitative research. A previous crossover trial confirmed its benefit in patients breathless at rest, but the washout period was uncertain. Aim: To determine the washout period after use of the hand-held fan to inform accurate randomized controlled trial design. Design: An observational methodological study. Breathlessness intensity was measured using 100 mm visual analog scale and numerical rating scale, and “relief of breathlessness” was measured on a 5-point scale. Those benefitting from the fan provided visual analog scale/numerical rating scale scores until (1) scores returned to baseline values or (2) until response had plateaued. The primary outcome measure was the time (in minutes) to reach either component of the primary study endpoint. Settings/participants: Four in-/out-patient hospice/hospital units; participants had chronic refractory breathlessness using the fan. Results: Overall, 31 patients participated (mean age: 74.8 years; range: 49–98 years, standard deviation = 11.5 years); 64% were males. Approximately, half of the sample experienced benefit of moderate effect size. The relative reduction in breathlessness relative to the mean baseline score for the sample was 27% for the visual analog scale and 19% for the numerical rating scale. Conclusion: Feasibility work is essential, even for simple widely employed interventions.
Athletic Performance at the NFL Scouting Combine After Anterior Cruciate Ligament Reconstruction
Authors: Keller Robert A. , Mehran Nima , Austin William , Marshall Nathan E. , Bastin Kevin , Moutzouros Vasilios 
Published: October 2015

Background: Anterior cruciate ligament (ACL) injuries are common and potentially career ending in the National Football League (NFL). Although statistical performance has been demonstrated after ACL reconstruction, functional performance is not well defined. Purpose/Hypothesis: The purpose of this study was to determine the functional performance of NFL combine participants after ACL reconstruction compared with an age-, size-, and position-matched control group. The hypothesis was that there would be no difference between players after ACL reconstruction as compared with controls in functional athletic performance. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 98 NFL-caliber athletes who had undergone primary ACL reconstruction and participated in the NFL scouting combine between 2010 and 2014 were reviewed and compared with an age-, size-, and position-matched control group. Data recorded for each player included a 40-yard dash, vertical leap, broad jump, shuttle drill, and 3-cone drill. Results: With regard to speed and acceleration, the mean 40-yard dash time for ACL-reconstructed players was 4.74 seconds (range, 4.33-5.55 seconds) compared with controls at 4.74 seconds (range, 4.34-5.38 seconds; P = .96). Jumping performance was also similar, with a mean vertical leap for ACL-reconstructed players of 33.35 inches (range, 23-43 inches) and broad jump of 113.9 inches (range, 96-136 inches) compared with respective values for the controls of 33.22 inches (range, 23.5-43.5 inches; P = .84) and 113.9 inches (range, 92-134 inches; P = .99). Agility and quickness testing measures also did not show a statistically significantly difference, with ACL-reconstructed players performing the shuttle drill in 4.37 seconds (range, 4.02-4.84 seconds) and the 3-cone drill in 7.16 seconds (range, 6.45-8.14 seconds), respectively, compared with respective times for the controls of 4.37 seconds (range, 3.96-5.00 seconds; P = .91) and 7.18 seconds (range, 6.64-8.24 seconds; P = .75). Conclusion: This study suggests that after ACL reconstruction, high-caliber athletes can achieve equivalent levels of performance with no statistically significant differences compared with matched controls. This information is unique when advising high-level athletes on athletic performance after ACL reconstruction, suggesting that those who fully recover and return to play appear to have no decrement in athletic performance.
Physical preparation of alginate/chitosan polyelectrolyte complexes for biomedical applications
Authors: Alsharabasy Amir M , Moghannem Saad A , El-Mazny Waleed N 
Published: October 2015

Polyelectrolyte complexes represent a special class of polymeric compounds consisting of stoichiometric equivalents of oppositely charged polyions interacting together spontaneously to yield a complex in different forms. The present study aimed at preparing coacervates of alginate and chitosan polymers ready for casting as wound dressing films. This was based on controlling the pH of solutions and the reactions speed through controlling the rate of mixing of the polymers solutions together without using any water-miscible solvents. Alginate was modified with radiation and oxidation, and the interactions of the resulting chains and chitosan chains were tested with FTIR spectroscopy and scanning of the resulting films with SEM. This work showed the ability to prepare a complex of highly connected polymeric chains for further biomedical applications. This complex in the form of hydrogel could enhance the proliferation of cells in vitro and the healing efficiency with accelerating the wound closure rate as evidenced through the histological observations.
Patient-Reported Outcomes and Return to Activity After Peroneus Brevis Repair
Authors: Steginsky Brian , Riley Aimee , Lucas Douglas E. , Philbin Terrence M. , Berlet Gregory C. 
Published: October 2015

Background: There is limited data on functional outcomes after primary repair of partial peroneal tendon tears. Previous reports have been limited by small cohorts, duration of follow-up, and often included both tenodesis and primary repair. The purpose of this study was to report the functional outcomes and return to activity in the largest cohort to date with partial peroneal tendon tears treated with primary repair. Methods: A chart review identified all patients who underwent primary repair of the peroneus brevis tendon from 2008 to 2012. Demographic data, magnetic resonance imaging findings, and postoperative complications were reviewed. Patients were asked to complete a follow-up questionnaire, Foot and Ankle Ability Measure (FAAM), and Foot Function Index (FFI). There were 201 patients who underwent primary repair of the peroneus brevis tendon. The average age at time of operation was 44.3 years. Seventy-one patients returned the follow-up questionnaires with an average follow-up of 4.6 years. Fifty-two patients completed the FFI questionnaire preoperatively and postoperatively. Results: Fifty-nine patients (83.1%) reported a return to regular exercise and sports at final follow-up. At 1 year postoperatively, 76.5% of patients returned to the same preinjury activities, and 62.3% returned to the same level of preinjury activity. Furthermore, 85.9% of patients were satisfied with their outcome, and 91.4% of patients reported they would choose to undergo the same procedure again. The mean FAAM score was 85.2 at follow-up. The mean preoperative and postoperative FFI score was 41.1 and 12.2, respectively. There was a significant improvement in the FFI score of 28.9 after primary peroneus brevis tendon repair ( P < .001). Conclusion: Primary repair of peroneus brevis tendon provided consistent improvement in functional outcomes in the majority of patients, as measured by a validated scoring system, the FFI. FAAM scores demonstrated good function compared to historical controls. The majority of patients were able to return to preinjury activity. Level of Evidence: Level IV, retrospective case series.
Acute intermittent porphyria: Comorbidity and shared familial
risks with schizophrenia and bipolar disorder in Sweden
Authors: Cederlöf Martin , Bergen Sarah E. , Larsson Henrik , Landén Mikael , Lichtenstein Paul 
Published: October 2015

SummaryAcute intermittent porphyria (AIP) has been associated with schizophrenia in
some studies, but prior research is limited by the absence of comparison
populations. Here, we linked Swedish registers to examine the risk of
schizophrenia and bipolar disorder in 717 individuals diagnosed with AIP and
their first-degree relatives, compared with matched individuals without AIP
and their first-degree relatives. Individuals with AIP had a fourfold
increased risk of schizophrenia or bipolar disorder. Similarly, relatives of
individuals with AIP had double the risk of schizophrenia or bipolar
disorder, suggesting that these associations may be as a result of common
genetic influences.
Effects of the MAOA gene and levels of exposure
to violence on antisocial outcomes
Authors: Ouellet-Morin Isabelle , Côté Sylvana M. , Vitaro Frank , Hébert Martine , Carbonneau René , Lacourse Éric , Turecki Gustavo , Tremblay Richard E. 
Published: October 2015

BackgroundThe monoamine oxidase A (MAOA) gene has been shown to
moderate the impact of maltreatment on antisocial behaviour. Replication
efforts have, however, yielded inconsistent results.AimsTo investigate whether the interaction between the MAOA
gene and violence is present across the full distribution of violence or
emerges at higher levels of exposure.MethodParticipants were 327 male members of the Québec Longitudinal Study of
Kindergarten Children. Exposure to violence comprised retrospective
reports of mother's and father's maltreatment, sexual and physical abuse.
Conduct disorder and antisocial personality symptoms were assessed in
semi-structured interviews and partner violence, property-violent crimes
and arrest were self-reported.ResultsNon-linear interactions between the MAOA gene and
violence were detected, suggesting that the genetic moderation may come
about once a certain level of violence is experienced.ConclusionsFuture studies should investigate the mechanisms translating substantial
violence exposure, which could, subsequently, trigger the expression of
genetically based differences in antisocial behaviour.
Neuroestradiol in the Stalk Median Eminence of Female Rhesus Macaques Decreases in Association With Puberty Onset
Authors: Kenealy Brian P. , Keen Kim L. , Kapoor Amita , Terasawa Ei 
Published: October 2015

Abstract
In primates, despite the fact that GnRH neurons are mature at birth, a gonadal steroid independent central inhibition restrains the initiation of puberty. The neural substrates responsible for this central inhibition, however, are unclear. In this study, we tested the hypothesis that neuroestradiol release in the hypothalamus decreases prior to the pubertal increase in GnRH release. We found that in female monkeys at the prepubertal stage, when GnRH release was low, estradiol (E2) levels in the stalk-median eminence of the hypothalamus were higher than those in older, early pubertal females in which nocturnal GnRH release begins to increase. Furthermore, estrone (E1) levels were higher in the stalk-median eminence of prepubertal and early pubertal monkeys compared with midpubertal monkeys, which have the highest GnRH release. The elevated E2 and E1 levels at the prepubertal stage are likely hypothalamic in origin because circulating E2 and E1 levels in prepubertal and early pubertal monkeys were much lower than those in midpubertal monkeys. Heightened synthesis and release of neuroestradiol during the prepubertal period and subsequent reduction at puberty onset indicate possible roles for neuroestradiol in central inhibition of GnRH release. The mechanism governing the reduction in neuroestradiol synthesis at puberty onset remains to be determined.
SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes
Authors: Galloway Jamie R. , Bethea Maigen , Liu Yanping , Underwood Rachel , Mobley James A. , Hunter Chad S. 
Published: October 2015

AbstractIslet-1 (Isl1) is a Lin11, Isl1, Mec3 (LIM)-homeodomain transcription factor important for pancreatic islet cell development, maturation, and function, which largely requires interaction with the LIM domain-binding protein 1 (Ldb1) coregulator. In other tissues, Ldb1 and Isl1 interact with additional factors to mediate target gene transcription, yet few protein partners are known in β-cells. Therefore, we hypothesize that Ldb1 and Isl1 participate in larger regulatory complexes to impact β-cell gene expression. To test this, we used cross-linked immunoprecipitation and mass spectrometry to identify interacting proteins from mouse β-cells. Proteomic datasets revealed numerous interacting candidates, including a member of the single-stranded DNA-binding protein (SSBP) coregulator family, SSBP3. SSBPs potentiate LIM transcription factor complex activity and stability in other tissues. However, nothing was known of SSBP3 interaction, expression, or activity in β-cells. Our analyses confirmed that SSBP3 interacts with Ldb1 and Isl1 in β-cell lines and in mouse and human islets and demonstrated SSBP3 coexpression with Ldb1 and Isl1 pancreas tissue. Furthermore, β-cell line SSBP3 knockdown imparted mRNA deficiencies similar to those observed upon Ldb1 reduction in vitro or in vivo. This appears to be (at least) due to SSBP3 occupancy of known Ldb1-Isl1 target promoters, including MafA and Glp1r. This study collectively demonstrates that SSBP3 is a critical component of Ldb1-Isl1 regulatory complexes, required for expression of critical β-cell target genes.
From human organism to society and Earth´s biosphere: evolution of term of homeostasis within the framework of three paradigms
Authors: Буданов  , Budanov V. , Филатова  , Filatova O. , Хадарцев  , Khadartsev Aleksandr , Попов  , Popov Yuriy 
Published: October 2015

The problem of philosophical and scientific interpretation of homeostasis has been discussed for more than 150 years. The works of Claude Bernard, W.B. Cannon and P.K. Anokhin fill the basic philosophy of homeostasis, but that works have not provided a formal description of the condition of organism. At the same time within the framework of the third paradigm a new insights of chaos which in modern philosophy is treated only as deterministic chaos are offered. Some forecasts for the development of society and humanity in the future in terms of the analysis of the present are presented. An expanded interpretation of homeostasis in its historical and semantic development is presented. The proof of the commonness in dynamics of behavior of individual organism and the whole society is given.
La influencia de las TIC en el desempeño académico: evidencia de la prueba PIRLS en Colombia 2011
Authors: Botello Peñaloza Héctor , López Alba Andrea 
Published: October 2015

<p>lector de niños de cuarto de primaria, utilizando la prueba Progreso Internacional en Competencia Lectora (pirls) de 2011 para una muestra de alumnos en Colombia. Para la estimación se utilizaron técnicas de regresión lineal múltiple,<br />ya que permite el control de variables institucionales, familiares e individuales, para así hallar el efecto directo que tienen las tic en el puntaje promedio del estudiante. Los resultados muestran que la tenencia de tecnologías y el<br />uso de éstas en el aprendizaje escolar mediante actividades de lectura de contenido digital, afectan positivamente el desempeño lector de los niños, incrementando el puntaje promedio entre un 21% y un 31%. Asimismo, el uso de computador (PC) para efectos de mejorar la lectura aporta un 32% adicional en la calificación de la prueba respecto a los niños que no usan PC para esto, siendo la variable de mayor peso. No obstante, se hace énfasis en el uso adecuado de las tic, ya que su utilización llana tanto en el hogar como en el colegio puede afectar negativamente el desempeño dado que se utilizan para otros objetivos fuera del escolar.<br />Palabras clave: Colombia, desempeño lector, educación primaria, pirls, tic.</p>
Una mirada a los estilos de aprendizaje de los estudiantes de la UPTC desde la noción de nativo digital
Authors: Saavedra Bautista Claudia Esperanza , Parra Valencia Jorge Andrick 
Published: October 2015

<p>Este artículo presenta resultados de la investigación “Ambiente virtual de aprendizaje a partir de estilos de aprendizaje en nativos digitales”, cuyo objetivo fue identificar los estilos de aprendizaje de mayor predominancia de estudiantes<br />desde el concepto `nativo digital` de la Facultad de Ciencias de la Educación de la Universidad Pedagógica y Tecnológica de Colombia, con el fin de describir sus dimensiones de personalidad dentro de un proceso de aprendizaje y, en este sentido, poder ofrecer un ambiente virtual de aprendizaje acorde con sus estilos de aprender. Se trata de una investigación cuasiexperimental con enfoque cuantitativo que se llevó a cabo durante tres semestres consecutivos.<br />El análisis estadístico permite concluir que el estilo de aprendizaje reflexivo presenta una baja predominancia frente a los demás estilos de aprendizaje. Esto sugiere formular prácticas pedagógicas pensadas desde el conocimiento del<br />estudiante, orientadas al fortalecimiento de su capacidad reflexiva.<br />Palabras clave:aprendizaje, enseñanza, estilo de aprendizaje, dimensión de personalidad, nativo digital.</p>