bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor-Faktor Penyebab Anemia pada Ibu Hamil : Analisis Hubungan dengan Umur dan Kunjungan ANC di Puskesmas Klabang
Authors: Medyawati Cici , Ermawati Iit , Supriyadi Bagus 
Published: July 2024

Anemia merupakan masalah gizi yang perlu mendapat perhatian karena anemia pada ibu hamil dapat meningkatkan risiko kelahiran prematur, kematian ibu dan anak, serta penyakit infeksi. Tujuan penelitian adalah menganalisis faktor-faktor yang Berhubungan Dengan Kejadian Anemia Pada Ibu Hamil di Wilayah Kerja Puskesmas Klabang Tahun 2023. Desain penelitian ini adalah penelitian kuantitatif dengan pendekatan korelasional dan termasuk penelitian crossectional. Populasi dalam penelitian ini adalah semua ibu hamil yang ada di Wilayah Kerja Puskesmas Klabang Tahun 2023 sebanyak 31 orang. Besar sampel dalam penelitian ini sebesar 31 orang diambil secara total sampling. Pengumpulan data dengan menggunakan kuesioner kemudian data diolah dengan menggunakan SPSS dengan menggunakan regresi logistik. Hasil analisis data diketahui bahwa sebagian besar responden berusia 20-35 tahun sebanyak 16 orang (51,6%), seorang primipara sebanyak 14 orang (45,2%), tidak patuh dalam kunjungan ANC terpadu sebanyak 16 orang (51,6%), suami mendukung sebanyak 19 orang (61,3%), tidak mengalami anemia sebanyak 17 orang (54,8%). Berdasarkan analisis regresi logistik diketahui bahwa nilai signifikansi (p value) pada variabel umur sebesar 0,042, pada variabel paritas sebesar 0,035, ANC sebesar 0,045 dan pada variabel dukungan suami sebesar 0,352. Variabel yang memiliki hubungan atau pengaruh terhadap kejadian anemia adalah umur, paritas dan kunjungan ANC karena memiliki nilai p value ≤ 0,05. Sementara pada variable dukungan suami tidak berhubungan karena memiliki nilai p valu >0,05. Kunjungan ANC merupakan faktor dominan yang berhubungan dengan anemia. Disarankan ibu untuk aktif dalam melakukan pemeriksaan kesehatan dan memanfaatkan layanan kesehatan lainnya tujuannya unutk mengindentifikasi dan mengatasi masalah kesehatan, termasuk anemia,sedini mungkin.
Kajian literatur: Implementasi Realistic Mathematics Education (RME) pada kemampuan representasi matematis
Authors: Lestari Liya , Maryati Iyam , Sundayana Rostina , Afriansyah Ekasatya Aldila 
Published: July 2024

Riset ini didasarkan atas kemampuan representasi siswa yang masih lemah sebab proses belajar mengajar tidak secara maksimal mengikutsertakan siswa untuk mengotak-atik benda di lingkungan sekitar sebagai proses awal untuk menguasai konsep matematika. Adapun tujuan riset ini adalah melakukan kajian literatur terkait dengan implementasi RME terhadap kemampuan representasi matematis siswa menggunakan metode yang SLR (Systematic Literature Review), yang didasarkan pada penelitian terdahulu yang relevan mengenai RME dan kemampuan representasi matematis. Dari pencarian menggunakan kata kunci, ditemukan sebanyak 28 artikel terkait. Kemudian, artikel-artikel tersebut dipilih 12 artikel jurnal yang memiliki topik penelitian relevan yang ter-indeks Google Scholar, Sinta 2, Sinta 3, dan Sinta 5. Artikel-artikel yang diperoleh, merupakan hasil dari pencarian data di base Google Scholar dan Mendeley. Hasil riset mengungkapkan bahwa analisis implementasi RME pada kemampuan representasi matematis efektif digunakan.
PERMOHONAN DISPENSASI KAWIN PERSPEKTIF MASHLAHAH MURSALAH
Authors: Kosiungan Yon Indra Wahyudi , Faruq Ahmad 
Published: July 2024

Penelitian ini menggunakan jenis penelitian kualitatif dengan metode pendekatan yuridis-sosiologis. Teknik pengumpulan data yang digunakan adalah wawancara, observasi, dan studi dokumen. Peraturan mengenai dispensasi nikah yang diatur oleh Pasal 7 Undang-Undang Nomor 16 Tahun 2019 tentang Batas Usia Perkawinan dapat ditinjau dari perspektif maá¹£hlaá¸¥ah mursalah. Hal ini dikarenakan syarat-syarat maá¹£hlaá¸¥ah mursalah dalam istinbaá¹­ hukum terpenuhi, yaitu kemaslahatan tersebut harus sejalan dengan tujuan utama syariat, seperti memelihara agama, memelihara jiwa, memelihara akal, memelihara keturunan, dan memelihara harta. selama tidak bertentangan dengan naá¹£h, maka dapat dipertimbangkan dalam hal dispensasi nikah.

Kata kunci: Dispensasi, Perkawinan. Maá¹£hlaá¸¥ah Mursalah, Anak di Bawah Umur, Undang-Undang Nomor 1 Tahun 1974, Undang-Undang Nomor 16 Tahun 2019.
Exploring essential oil-based bio-composites: molecular docking and in vitro analysis for oral bacterial biofilm inhibition
Authors: Ullah Niamat , Hasnain Syed Zia Ul , Baloch Rabia , Amin Adnan , Nasibova Aygun , Selakovic Dragica , Rosic Gvozden Luka , Islamov Sokhib , Naraliyeva Nasibakhon , Jaradat Nidal , Mammadova Afat O 
Published: July 2024

Oral bacterial biofilms are the main reason for the progression of resistance to antimicrobial agents that may lead to severe conditions, including periodontitis and gingivitis. Essential oil-based nanocomposites can be a promising treatment option. We investigated cardamom, cinnamon, and clove essential oils for their potential in the treatment of oral bacterial infections using in vitro and computational tools. A detailed analysis of the drug-likeness and physicochemical properties of all constituents was performed. Molecular docking studies revealed that the binding free energy of a Carbopol 940 and eugenol complex was −2.0 kcal/mol, of a Carbopol 940-anisaldehyde complex was −1.9 kcal/mol, and a Carbapol 940-eugenol-anisaldehyde complex was −3.4 kcal/mol. Molecular docking was performed against transcriptional regulator genes 2XCT, 1JIJ, 2Q0P, 4M81, and 3QPI. Eugenol cinnamaldehyde and cineol presented strong interaction with targets. The essential oils were analyzed against Staphylococcus aureus and Staphylococcus epidermidis isolated from the oral cavity of diabetic patients. The cinnamon and clove essential oil combination presented significant minimum inhibitory concentrations (MICs) (0.0625/0.0312 mg/mL) against S. epidermidis and S. aureus (0.0156/0.0078 mg/mL). In the anti-quorum sensing activity, the cinnamon and clove oil combination presented moderate inhibition (8 mm) against Chromobacterium voilaceum with substantial violacein inhibition (58% ± 1.2%). Likewise, a significant biofilm inhibition was recorded in the case of S. aureus (82.1% ± 0.21%) and S. epidermidis (84.2% ± 1.3%) in combination. It was concluded that a clove and cinnamon essential oil-based formulation could be employed to prepare a stable nanocomposite, and Carbapol 940 could be used as a compatible biopolymer.
Cheminformatics-based identification of phosphorylated RET tyrosine kinase inhibitors for human cancer
Authors: Talukder Md. Enamul Kabir , Aktaruzzaman Md. , Siddiquee Noimul Hasan , Islam Sabrina , Wani Tanveer A. , Alkahtani Hamad M. , Zargar Seema , Raihan Md. Obayed , Rahman Md. Mashiar , Pokhrel Sushil , Ahammad Foysal 
Published: July 2024

BackgroundRearranged during transfection (RET), an oncogenic protein, is associated with various cancers, including non-small-cell lung cancer (NSCLC), papillary thyroid cancer (PTC), pancreatic cancer, medullary thyroid cancer (MTC), breast cancer, and colorectal cancer. Dysregulation of RET contributes to cancer development, highlighting the importance of identifying lead compounds targeting this protein due to its pivotal role in cancer progression. Therefore, this study aims to discover effective lead compounds targeting RET across different cancer types and evaluate their potential to inhibit cancer progression.MethodsThis study used a range of computational techniques, including Phase database creation, high-throughput virtual screening (HTVS), molecular docking, molecular mechanics with generalized Born surface area (MM-GBSA) solvation, assessment of pharmacokinetic (PK) properties, and molecular dynamics (MD) simulations, to identify potential lead compounds targeting RET.ResultsInitially, a high-throughput virtual screening of the ZINC database identified 2,550 compounds from a pool of 170,269. Subsequent molecular docking studies revealed 10 compounds with promising negative binding scores ranging from −8.458 to −7.791 kcal/mol. MM-GBSA analysis further confirmed the potential of four compounds to exhibit negative binding scores. MD simulations demonstrated the stability of CID 95842900, CID 137030374, CID 124958150, and CID 110126793 with the target receptors.ConclusionThese findings suggest that these selected four compounds have the potential to inhibit phosphorylated RET (pRET) tyrosine kinase activity and may represent promising candidates for the treatment of various cancers.
Enhanced atherosclerosis in apolipoprotein E knockout rabbits: role of apoB48-rich remnant lipoproteins
Authors: Niimi Manabu , Chen Yajie , Zhao Huanyu , Tang Xiangming , Matsuhisa Fumikazu , Zhou Huanjin , Yan Haizhao , Chen Lu , Kitajima Shuji , Sato Akira , Fan Jianglin 
Published: July 2024

IntroductionApolipoprotein E (apoE) acts as a binding molecule for both the low-density lipoprotein receptor and the lipoprotein receptor-related protein and this function is essential for facilitating the hepatocyte uptake of lipoproteins containing apoB. The absence of apoE leads to increased atherogenicity in both humans and mice, although the precise molecular mechanisms remain incompletely understood.ObjectivesThis study aimed to investigate the susceptibility of apoE knockout (KO) rabbits, in comparison with wild-type (WT) rabbits, to diet-induced hyperlipidemia and atherosclerosis.MethodsApoE KO rabbits and WT rabbits were fed a diet containing 0.3% cholesterol for 16 weeks. Plasma lipid levels, lipoproteins, and apolipoproteins were analyzed. Atherosclerosis was evaluated at the endpoint of experiments. In addition, we evaluated the oxidizability of those lipoproteins containing apoB to investigate the possible mechanisms of atherosclerosis.ResultsMale apoE KO rabbits showed significantly elevated levels of total cholesterol and triglycerides compared to WT rabbits, while female apoE KO rabbits displayed similar high total cholesterol levels, albeit with significantly higher triglycerides levels than WT controls. Notably, both male (2.1-fold increase) and female (1.6-fold increase) apoE KO rabbits exhibited a significantly augmented aortic lesion area compared to WT controls. Pathological examination showed that the increased intimal lesions in apoE KO rabbits were featured by heightened infiltration of macrophages (2.7-fold increase) and smooth muscle cells (2.5-fold increase). Furthermore, coronary atherosclerotic lesions were also increased by 1.3-fold in apoE KO rabbits. Lipoprotein analysis revealed that apoB48-rich beta-very-low-density lipoproteins were notably abundant in apoE KO rabbits, suggesting that these remnant lipoproteins of intestinal origin serve as the primary atherogenic lipoproteins. Moreover, apoB48-rich remnant lipoproteins isolated from apoE KO rabbits exhibited heightened susceptibility to copper-induced oxidation.ConclusionsThe findings indicate that apoB48-rich remnant lipoproteins, resulting from apoE deficiency, possess greater atherogenic potential than apoB100-rich remnant lipoproteins, regardless of plasma TC levels.
Imbalance of Th17 cells, Treg cells and associated cytokines in patients with systemic lupus erythematosus: a meta-analysis
Authors: Huang Jinge , Li Xiaolong , Zhu Qingmiao , Wang Meijiao , Xie Zhijun , Zhao Ting 
Published: July 2024

ObjectiveThis article aims to investigate the changes of T helper 17 (Th17) cells, regulatory T (Treg) cells and their associated cytokines in patients with systemic lupus erythematosus (SLE).MethodsMultiple databases were investigated to identify articles that explored Th17 cells, Treg cells and relevant cytokines in SLE patients. A random effects model was used for calculating pooled standardized mean differences. Stata version 15.0 was utilized to conduct the meta-analysis.ResultsThe levels of Th17 cells, IL-17, IL-6, IL-21 and IL-10 were higher in SLE patients than in healthy controls (HCs), but the TGF-β levels were lower. The percentage of Treg cells was lower than HCs in SLE individuals older than 33. Among studies that had 93% or lower females, the percentage of Th17 cells was greater in patients than in HCs. However, the percentage of Treg cells was lower when the proportion of females was less than 90%. Patients with lupus nephritis or active SLE had an increased proportion of Th17 cells and a decreased proportion of Treg cells.ConclusionsThe increased level of Th17 cells and related cytokines could be the main reason for the elevated Th17/Treg ratio in SLE. The percentages of Th17 and Treg cells were associated with gender, age, disease activity and kidney function. Furthermore, the reduced proportions of Treg cells may primarily result in a rise in the Th17/Treg ratio in older or active SLE patients.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42023454937.
Biogeographic variation in environmental and biotic resistance modifies predicted risk of marine invasions by ships
Authors: Bonfim Mariana , Bunson Samuel L. , Sellers Andrew J. , Torchin Mark E. , Ruiz Gregory M. , Freestone Amy L. 
Published: July 2024

IntroductionGlobal shipping has accelerated the spread of non-native species. Factors such as environmental filtering and interactions with local biota can affect invasion likelihood, yet their relative contribution to predicting invasion risk remains unresolved. To test how abiotic filters and an experimentally-derived measure of biotic resistance interact with propagule pressure, we developed an integrated model to evaluate their relative effects on invasion risk of marine biofouling organisms to different focal port regions. We predicted that environmental filtering impacts invasion risk when fewer but stronger connections are part of the network. Further, predation is a mechanism of biotic resistance, which can reduce invasion risk, with most pronounced effects predicted in the tropics that decline at higher latitudes.MethodsWe examined shipping traffic and predation impact at three coastal bioregions spanning 47-degrees of latitude al range in the Northeast Pacific (Alaska, California, and Panama). We used vessel traffic databases to characterize propagule pressure and construct a worldwide port network of marine shipping routes and ports. Environmental resistance was estimated using temperature and salinity data from donor and recipient regions. We further used standardized predator exposure experiments to quantify predation impact on fouling community biomass as an estimate of potential for biotic resistance. We then expanded on existing models of relative invasion risk to incorporate the probability that propagules will survive predation by local predators and overcome environmental filtering to generate a predicted invasion risk for each port.ResultsEnvironmental filtering in all regions and predation pressure in the tropics worked to reduce the invasion risk, resulting in markedly different cumulative risk profiles over time among regions.DiscussionIn an increasingly connected world with more vessel traffic, our results highlight that while the number and distribution of shipping routes are important to understand risk, abiotic and biotic filters can modify model predictions.
Serum uric acid and high-sensitivity C-reactive protein levels among people living with HIV on dolutegravir and ritonavir-boosted atazanavir-based antiretroviral therapy: a comparative cross-sectional study
Authors: Waritu Nuredin Chura , Nair Suresh Kumar P. , Usure Rashed Edris , Jemal Mohammed 
Published: July 2024

BackgroundAfter the introduction of antiretroviral therapy, the care given to people living with HIV has become complicated by the appearance of comorbidities as a result of HIV and HAART toxicities, in which cardiovascular disease got the most attention. So, this study aimed to assess serum uric acid and high-sensitivity C-reactive protein levels among people living with HIV on dolutegravir (DTG) and ritonavir-boosted atazanavir (ATV/r)-based therapy.MethodsAn institutional-based comparative cross-sectional study was conducted from November 4, 2021, to January 4, 2022. An equal number of dolutegravir- and ritonavir-boosted atazanavir-treated patients (n = 86 each) were enrolled. A consecutive sampling method was used to select participants. Data were entered into Epidata version 4.6, exported to SPSS version 25.0, and analyzed using Chi-square, Student’s t-test, Mann–Whitney U-test, and logistic regression. Statistical significance was set at p &lt; 0.05.ResultsThe prevalence of hyperuricemia and high-sensitivity C-reactive protein levels ≥2 mg/L were 46.5% (40/86) and 24.4% (21/86) in the DTG group, and 30.2% (26/86) and 44.2 (38/86) in the ATV/r group, respectively. When compared to ATV/r, a higher mean level of uric acid was found among DTG-based regimens (5.38 mg/dL). Duration of ART (AOR = 2, 95% CI: 1.2, 4.4) and DTG-based regimen (AOR = 1.9, 95% CI: 1.04, 3.8) were significant predictors of developing hyperuricemia. ATV/r-based regimen (AOR = 3, 95% CI: 1.5, 8.3) and high waist circumference (AOR = 2.5, 95% CI: 1, 3.5) were significantly associated with increased high-sensitivity C-reactive protein levels.ConclusionIt is observed that DTG-based and ATV/r-based ART are associated with hyperuricemia and increased high-sensitivity C-reactive protein levels, respectively. Therefore, it is important to consider and evaluate serum uric acid and high-sensitivity C-reactive protein levels in patients taking DTG and ATV/r-based ART, as well as among those on HAART for years and with a higher waist circumference, so as to detect and prevent early the risk of having CVD.
Casual effects of telomere length on sarcoidosis: a bidirectional Mendelian randomization analysis
Authors: Zhu Shiben , Hao Ziyu , Chen Qihang , Liu Xiaoliu , Wu Wenyan , Luo Yanping , Zhang Fang 
Published: July 2024

BackgroundTelomere length, crucial for genomic stability, have been implicated in various inflamm-aging diseases, but their role in sarcoidosis remains unexplored.ObjectiveThis study aims to explore the casual effects between TL and sarcoidosis via a bidirectional Mendelian Randomization (MR) study.MethodsWe examined single nucleotide polymorphisms (SNPs) associated with TL and sarcoidosis, utilizing available open-access genome-wide association study (GWAS) databases from the UK Biobank and FinnGen. We employed five MR techniques, including Inverse Variance Weighted (IVW), MR Egger, weighted median (WM), Robust adjusted profile score (RAPS), and Maximum likelihood, to assess causal relationships and explore pleiotropy.ResultsSummary data extracted from GWAS datasets of TL (n = 472,174) and (n = 217,758) of European ancestry. Employing 130 SNPs with genome-wide significance as instrumental factors for TL, we detect a significant negative correlation between TL and sarcoidosis (OR: 0.682, 95% confidence interval: 0.524–0.888, p: 0.0045). Similarly, utilizing 6 SNPs with genome-wide significance as instrumental factors for sarcoidosis, we fail to identify a noteworthy association between sarcoidosis and TL (OR: 0.992, 95% confidence interval: 0.979–1.005, p: 0.2424).ConclusionOur results suggest that longer telomeres may reduce the risk of sarcoidosis, highlighting TL as a potential biomarker for diagnosis and long-term monitoring. Understanding the critical role of telomere shortening enables more effective focus on diagnosing, treating, and curing sarcoidosis linked to telomeres. Clinical investigations into treatments that enhance TL are warranted.
Genomic study of Acinetobacter baumannii strains co-harboring blaOXA-58 and blaNDM-1 reveals a large multidrug-resistant plasmid encoding these carbapenemases in Brazil
Authors: Rodrigues Daiana Cristina Silva , Silveira Melise Chaves , Pribul Bruno Rocha , Karam Bruna Ribeiro Sued , Picão Renata Cristina , Kraychete Gabriela Bergiante , Pereira Felicidade Mota , de Lima Rildo Mendes , de Souza Antonio Kleber Gomes , Leão Robson Souza , Marques Elizabeth Andrade , Rocha-de-Souza Cláudio Marcos , Carvalho-Assef Ana Paula D'Alincourt 
Published: July 2024

IntroductionAcinetobacter baumannii contributes significantly to the global issue of multidrug-resistant (MDR) nosocomial infections. Often, these strains demonstrate resistance to carbapenems (MDR-CRAB), the first-line treatment for infections instigated by MDR A. baumannii. Our study focused on the antimicrobial susceptibility and genomic sequences related to plasmids from 12 clinical isolates of A. baumannii that carry both the blaOXA-58 and blaNDM-1 carbapenemase genes.MethodsWhole-genome sequencing with long-read technology was employed for the characterization of an A. baumannii plasmid that harbors the blaOXA-58 and blaNDM-1 genes. The location of the blaOXA-58 and blaNDM-1 genes was confirmed through Southern blot hybridization assays. Antimicrobial susceptibility tests were conducted, and molecular characterization was performed using PCR and PFGE.ResultsMultilocus Sequence Typing analysis revealed considerable genetic diversity among blaOXA-58 and blaNDM-1 positive strains in Brazil. It was confirmed that these genes were located on a plasmid larger than 300 kb in isolates from the same hospital, which also carry other antimicrobial resistance genes. Different genetic contexts were observed for the co-occurrence of these carbapenemase-encoding genes in Brazilian strains.DiscussionThe propagation of blaOXA-58 and blaNDM-1 genes on the same plasmid, which also carries other resistance determinants, could potentially lead to the emergence of bacterial strains resistant to multiple classes of antimicrobials. Therefore, the characterization of these strains is of paramount importance for monitoring resistance evolution, curbing their rapid global dissemination, averting outbreaks, and optimizing therapy.