bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of extensive surgery in multidisciplinary approach of pterygopalatine/infratemporal fossa soft tissue sarcoma
Authors: Minard‐Colin Véronique , Kolb Frédéric , Saint‐Rose Christian , Fayard Florence , Janot François , Rey Annie , Canale Sandra , Julieron Morbize , Corradini Nadège , Raquin Marie‐Anne , Habrand Jean‐Louis , Grill Jacques , George Bernard , Ba Huy Patrice Tran , Couloignier Vincent , Terrier‐Lacombe Marie‐José , Luboinski Bernard , Valteau‐Couanet Dominique , Oberlin Odile 
Published: January 2013

AbstractBackgroundTo evaluate a strategy whereby extensive surgery ± external radiotherapy (RT) could improve local control in pterygopalatine/infratemporal fossa (PIF) sarcoma.ProcedureForty‐one patients with a diagnosis of sarcoma involving the PIF and referred to our Institute from 1984 to 2009 were included in the analysis. Patients received multidrug chemotherapy and radiotherapy ± surgery, depending on the period of treatment.ResultsThe median age at diagnosis was 7.6 years (range: 0.1–22 years). There were 36 RMS, 3 undifferentiated sarcoma and 2 other soft‐tissue sarcomas. Sixty‐eight percent of patients had meningeal risk factors at diagnosis. Local treatment consisted of RT alone in 19 patients, surgery in combination to RT in 19 patients and surgery alone in 3 patients. The local progression rate (LPR) at 5 years was 45% for the entire population, 59% for the 19 patients treated with RT alone and 34% for the 22 patients who had surgery as part of their treatment. All locoregional failures after extensive surgery occurred at the skull base and/or in leptomeningeal spaces.ConclusionsMultidisciplinary approach including extensive surgery for PIF sarcoma is feasible and yields good local control with 15/22 patients in local complete remission. Future studies are warranted to confirm these promising results, to evaluate the possibility of avoiding RT or limiting the RT field, and to extend the indication for extensive surgery to other “worse” sites of PM sarcoma such as the paranasal sinuses. Pediatr Blood Cancer 2013; 60: 928–934. © 2013 Wiley Periodicals, Inc.
Prognostic factors and long‐term outcomes of nasopharyngeal carcinoma in children and adolescents
Authors: Hu Songliu , Xu Xiangying , Xu Jianyu , Xu Qingyong , Liu Shanshan 
Published: January 2013

AbstractBackgroundNasopharyngeal carcinoma (NPC) is a rare malignancy in children and adolescents, and the optimal treatment modality in youths has not been established. The aim of this study was to evaluate the long‐term treatment outcomes and complications associated with childhood and adolescent NPC.ProcedureFrom January 1985 to December 2004, the records of 95 patients with NPC and younger than 20 years of age were reviewed. All of the records were confirmed based on pathology via biopsy. The radiation doses to the primary tumors ranged from 64 to 80 Gy. The radiation doses to the metastatic cervical lymph nodes ranged from 60 to 74 Gy. The fractionated doses ranged from 1.8 to 2.0 Gy at 5 fractions/week. A total of 36 patients received chemotherapy before radiotherapy.ResultsThe 1‐, 3‐, 5‐, 10‐, and 15‐year overall survival (OS) rates were 92.6%, 63.2%, 54.7%, 46.8%, and 42.6%, respectively. The 1‐, 3‐, 5‐, 10‐, and 15‐year disease‐free survival (DFS) rates were 73.7%, 51.3%, 49.1%, 44.6%, and 42.6%, respectively. The clinical stage had a significant impact on OS (P = 0.007) and DFS (P = 0.012). Complete responders to therapy had superior OS (P < 0.001) and DFS (P < 0.001). Patients >12 years of age had better OS (P = 0.026) and DFS (P = 0.037).ConclusionsChildren and adolescents with advanced NPC had a relatively good rate of long‐term survival. However, 28% of the survivors had serious long‐term treatment‐related morbidities. In addition to clinical stage and complete response or partial response, age was an independent prognostic factor in pediatric and adolescent NPC. Pediatr Blood Cancer 2013; 60: 1122–1127. © 2012 Wiley Periodicals, Inc.
Magnesium homeostasis and hypomagnesemia in children with malignancy
Authors: Kaplinsky Chaim , Alon Uri S. 
Published: January 2013

AbstractHypomagnesemia is not uncommon among children with malignancies. It is especially seen in association with certain medications and can be further complicated by the presence of diarrhea and malnutrition. Severe hypomagnesemia may cause disturbances in the neuromuscular and cardiovascular systems. All patients with hypomagnesemia should be supplemented with the mineral, and urgent treatment is indicated when serum magnesium decreases below 1.0 mg/dl, a level under which symptoms may develop. This review addresses the essentials of magnesium physiology, and pathophysiology of hypomagnesemia, its etiologies, clinical manifestations and ways to treat it, with an emphasis on the child with hematologic/oncologic disorders. Pediatr Blood Cancer 2013; 60: 734–740. © 2013 Wiley Periodicals, Inc.
A proposed modification to Hy's law and Edish criteria in oncology clinical trials using aggregated historical data
Authors: Parks Daniel , Lin Xiwu , Painter Jeffery L. , Cheng Jie , Hunt Christine M. , Spraggs Colin F. , Nelson Jeanenne J. , Curtis Lloyd , Menius J. Alan , Lee Kwan R. 
Published: January 2013

ABSTRACTPurposeIdentifying drug‐induced liver injury is a critical task in drug development and postapproval real‐world care. Severe liver injury is identified by the liver chemistry threshold of alanine aminotransferase (ALT) >3× upper limit of normal (ULN) and bilirubin >2× ULN, termed Hy's law by the Food and Drug Administration. These thresholds require discontinuation of the causative drug and are seldom exceeded in most patient populations. However, because maintenance of therapy is critical in the treatment of advanced cancer, customized thresholds may be useful in oncology patient populations, particularly for those with baseline liver chemistries elevations.MethodsLiver chemistry data from 31 aggregated oncology clinical trials were modeled through a truncated robust multivariate outlier detection (TRMOD) method to develop the decision boundary or threshold for examining liver injury in oncology clinical trials.ResultsThe boundary of TRMOD identified outliers with an ALT limit 5.0× ULN and total bilirubin limit 2.7× ULN. In addition, TRMOD was applied to the aggregated oncology data to examine fold‐baseline ALT and total bilirubin, revealing limits of ALT 6.9× baseline and bilirubin 6.5× baseline. Similar ALT and bilirubin threshold limits were observed for oncology patients both with and without liver metastases.ConclusionsThese higher liver chemistry thresholds examining fold‐ULN and fold‐baseline data may be valuable in identifying potential severe liver injury and detecting liver safety signals of clinical concern in oncology clinical trials and postapproval settings while helping to avoid premature discontinuation of curative therapy. Copyright © 2013 John Wiley & Sons, Ltd.
Bold, smart, dangerous and evil: Perceived correlates of core psychopathic traits among jury panel members
Authors: Edens John F. , Clark John , Smith Shannon Toney , Cox Jennifer , Kelley Shannon E. 
Published: January 2013

ABSTRACTRelatively few studies have investigated how laypersons perceive psychopathy, what factors they believe to be commonly associated with this disorder, or what rater personality characteristics might predict perceived psychopathic traits of the target person. An ethnically diverse sample of 285 US community members attending jury duty reviewed a case vignette regarding a capital murder trial and then rated (1) their perceptions of the defendant's psychopathic characteristics loosely based on trait indicators from the Psychopathy Checklist‐Revised; (2) other characteristics of the defendant that might be associated with psychopathy (e.g. intelligence, violence potential); and (3) their own personality, using a very brief measure of Five Factor traits. Multivariate regression analyses indicated that participant ratings of psychopathy pertaining to the defendant were strongly associated with ratings on measures of his perceived boldness (i.e. social dominance and fearlessness), intelligence, violence potential, and perceptions that he was ‘evil’. Big Five personality characteristics of the layperson raters, however, were only modestly associated with their ratings of psychopathy for the defendant. We review these results in terms of the potential stigmatization of individuals labelled as ‘psychopaths’ in forensic settings. Copyright © 2013 John Wiley & Sons, Ltd.
Liquid ammonia treatment of (cationic) nanofibrillated cellulose/vermiculite composites
Authors: Thao Ho Thi Thu , Zimmermann Tanja , Caseri Walter Remo , Smith Paul 
Published: January 2013

AbstractLiquid ammonia was used to treat films of nanofibrillated cellulose (NFC), trimethylammonium‐modified NFC (TMA‐NFC), and their composites with vermiculite. Crystal structure, mechanical properties, water vapor permeation and water vapor adsorption of the resulting materials were investigated. Upon treatment, the crystal structure of (TMA‐)NFC both in presence and absence of vermiculite changed from cellulose I to III. With the exception of TMA‐NFC/vermiculite composites, pronounced effects on the addressed mechanical properties arose after exposure of the materials to ammonia. Furthermore, treatment of composite films with ammonia led to a distinct decrease in water vapor permeation. Remarkably, TMA‐NFC/vermiculite composites films show the best water vapor barrier properties, highest tensile strength and highest elastic modulus after treatment with liquid ammonia. This is regarded to be at least partially a consequence of electrostatic attraction between the positively charged ammonium groups in TMA‐NFC and the anionic silicate layers of vermiculite. © 2013 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2013
Miscibility in crystalline/amorphous blends of poly(3‐hydroxybutyrate)/DGEBA
Authors: Silva Leonel , Tognana Sebastián , Salgueiro Walter 
Published: January 2013

AbstractA differential scanning calorimetry (DSC) and small‐angle X‐ray scattering (SAXS) study of miscibility in blends of the semicrystalline polyester poly(3‐hydroxybutyrate) (PHB) and amorphous monomer epoxy DGEBA (diglycidyl ether of bisphenol A) was performed. Evidence of the miscibility of PHB/DGEBA in the molten state was found from a DSC study of the dependence of glass transition temperature (Tg) as a function of the blend composition and isothermal crystallization, analyzing the melting point (Tm) as a function of blend composition. A negative value of Flory–Huggins interaction parameter χPD was obtained. Furthermore, the lamellar crystallinity in the blend was studied by SAXS as a function of the PHB content. Evidence of the segregation of the amorphous material out of the lamellar structure was obtained. © 2013 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys, 2013
Feasibility Study of Virtual Target Scoring Using High‐Speed Imaging Techniques
Authors: Biswal Tapan K. , Sarkar Sumit , Adhikary Munesh 
Published: January 2013

AbstractMeasurements of consistency and accuracy are standard techniques to assess the performance of a weapon in case of direct fire kill mechanism. It is often determined from the scoring pattern of a witnessing target erected at a known distance in an open range making use of an in‐line CCD camera with suitable long‐range optics or using an array of acoustic/optical sensors in the close vicinity of the target. In the case of indoor range, acoustic and optical sensors are used to determine the same preferably for small‐caliber ammunitions. However, all these indirect methods are subjected to the constraint of triangulation error. In case of high‐caliber ammunitions, especially fired from tank guns, witnessing targets and acoustics methods are used although it is time‐consuming and labor‐intensive in nature. To overcome these difficulties a virtual scoring method is proposed. Herein, a high‐speed video camera is used for in‐line image acquisition of the projectile at the desired distance using long‐range optics. The virtual target is defined making use of an optical detector placed at the target distance and under the trajectory, where a trigger is generated when the projectile passes over it. This hardware trigger is sent to the high‐speed video camera and then the spatial coordinates of the projectile in the virtual plane is determined off‐line making use of necessary image processing and image analysis. A feasibility study of this technique was performed in a scaled‐down model and laid down in greater details.
Expectations of Being Helped in Return for Helping – Citizens, the State and the Local Area
Authors: Purdam Kingsley , Tranmer Mark 
Published: January 2013

ABSTRACTCitizens are increasingly being encouraged to take on new voluntary roles and responsibilities, such as, for example, looking after their local area and being involved in decision making. This move towards responsible citizenship is linked to the changing role of government, and the scaling down of the public services provided by the post war welfare state in many Western democracies.In order to develop our understanding of why certain people are more likely to help than others in different circumstances, we examine people's expectations of help in return for helping at the individual, local, and national level. Our analysis suggests that across Europe younger people compared with older people are more likely to expect help in return for helping. Men are more likely than women to expect help in return for helping. In terms of helping values and behaviour, people who see helping others as important and also those who report helping other people in practice are less likely to expect help in return. There are also considerable differences between countries in reported rates of expecting help in return for helping. The perceived local context of help is important, such that people are more likely to expect help in return for helping where their perception of people helping each other in the local area is low. Policies aimed at encouraging citizens to take on new responsibilities need to take account of how citizens view their reciprocal relationships with fellow citizens as well as the local context and the state infrastructure.Copyright © 2013 John Wiley & Sons, Ltd.
Crystal structure and phase transition in the doped super‐ionic conductor bismuth vanadate Bi4(V,Fe)2O11 revealed by neutron diffraction
Authors: Golosovsky I. V. , Golubko N. V. , Mosunov A. V. , Politova E. D. , Murasheva V. V. , Fortalnova E. A. , Rusakov V. S. , André G. , Porcher F. 
Published: January 2013

AbstractBismuth vanadate Bi4V2O11−y doped with Fe was studied by neutron diffraction. It was shown that Fe substitutes V only partially and the redundant iron forms an impurity hematite phase. In the sample with nominal content Bi4(V0.96Fe0.04)2O11−y a new phase transition within the frame of the monoclinic structure with the appearing of inversion center was discovered in the temperature region 200–300 °C. This transition was also confirmed by DTA experiments. Slow stabilization of the crystal structure with stabilization times of the order of hours, accompanied by a decrease of the unit cell volume, was observed. At high level of Fe doping, in addition to the dominant tetragonal γ‐phase some amount of the nanosized monoclinic α‐phase was detected.
The cluster‐size dependence of self‐diffusion behavior: A single Re adatom on a hexahedral surface
Authors: Dai Xiongying , Hu Wangyu , Yang Jianyu 
Published: January 2013

AbstractThe self‐diffusion of a single Re adatom on the Re clusters with 967–8263 atoms is studied. The minimum‐energy diffusion paths and the corresponding energy barriers for adatom diffusion on the Re hexahedral structure clusters surfaces are determined through a combination of the quenched molecular dynamics (MD) and nudged elastic bands (NEB) methods. Within the studied cluster size range, the ES barriers for an adatom across the step from a (0001) facet to a neighboring ($1{\bar {1}}01$) facet are the same. This means that the ES barriers are independent of the size of the clusters, while, the ES barriers for an adatom across the step between two ($1{\bar {1}}01$) facet have some dependence on the number of the shell (k). The ES barriers of the clusters with k = even number is lower than that of the clusters with k = odd number. For the former, the ES barriers decrease with increasing cluster size.
Probing factors affecting the Raman modes and structural collapse of single‐walled carbon nanotubes under pressure
Authors: Yao Mingguang , Lu Shuangchen , Xiao Junping , Yao Zhen , Jiang Linhai , Cui Tian , Liu Bingbing 
Published: January 2013

AbstractRaman spectra of single‐walled carbon nanotubes (SWNTs) with diameter distribution of 0.6–1.6 nm have been studied under high pressure. We focused on the dependence of radial R‐band frequency (associated with the radial breathing mode, RBM) on pressure, dωRBM/dP, and studied the effect of experimental factors on the structural changes of nanotubes under pressure. We found that the nanotube diameter and the pressure transmission medium (PTM) strongly affect the dωRBM/dP dependence of a nanotube in the experiments with PTMs, while the nanotube diameter and the intertube interactions between the tube walls play a dominant role on the upshift of RBMs for nanotubes without a PTM. These results are in line with the theoretical predictions that PTMs have a strong effect on the pressure‐induced shift in the R‐bands of SWNTs. In addition, we found that the collapse of nanotubes and their reversibility depend not only on diameter and pressure environment but also on the sample quality. This could explain that there have been different results reported by different groups even for nanotubes with the same diameter distribution.
A survey on mining multiple data sources
Authors: Ramkumar T. , Hariharan S. , Selvamuthukumaran S. 
Published: January 2013

AbstractAdvancements in computer and communication technologies demand new perceptions of distributed computing environments and development of distributed data sources for storing voluminous amount of data. In such circumstances, mining multiple data sources for extracting useful patterns of significance is being considered as a challenging task within the data mining community. The domain, multi‐database mining (MDM) is regarded as a promising research area as evidenced by numerous research attempts in the recent past. The methods exist for discovering knowledge from multiple data sources, they fall into two wide categories, namely (1) mono‐database mining and (2) local pattern analysis. The main intent of the survey is to explain the idea behind those approaches and consolidate the research contributions along with their significance and limitations.This article is categorized under:

Fundamental Concepts of Data and Knowledge > Data Concepts
Fundamental Concepts of Data and Knowledge > Motivation and Emergence of Data Mining
Large‐scale data mining using genetics‐based machine learning
Authors: Bacardit Jaume , Llorà Xavier 
Published: January 2013

AbstractIn the last decade, genetics‐based machine learning methods have shown their competence in large‐scale data mining tasks because of the scalability capacity that these techniques have demonstrated. This capacity goes beyond the innate massive parallelism of evolutionary computation methods by the proposal of a variety of mechanisms specifically tailored for machine learning tasks, including knowledge representations that exploit regularities in the datasets, hardware accelerations or data‐intensive computing methods, among others. This paper reviews different classes of methods that alone or (in many cases) combined accelerate genetics‐based machine learning methods. © 2013 Wiley Periodicals, Inc.This article is categorized under:

Technologies > Classification
Technologies > Computational Intelligence
Gain‐of‐function mutation in the KlPDR1 gene encoding multidrug resistance regulator in Kluyveromyces lactis
Authors: Balazfyova Zuzana , Hervay Nora Toth , Gbelska Yvetta 
Published: January 2013

AbstractKlPdr1p is a single Kluyveromyces lactis homologue of Saccharomyces cerevisiae ScPdr1p/ScPdr3p, the main transcriptional regulators of genes involved in S. cerevisiae multidrug resistance. KlPDR1 deletion leads to a sharp increase in K. lactis drug susceptibility. The presence of putative PDRE and YRE regulatory elements in the KlPDR1 gene promoter suggests an autoregulation of its transcription as well as its control by KlYap1p, the transcription factor involved in oxidative stress response. In this study, one plasmid‐borne Klpdr1‐1 allele that led to amino acid substitution (L273P) in the KlPdr1p was isolated. Overexpression of the Klpdr1‐1 allele from a multicopy plasmid in the K. lactis wild‐type and Klpdr1Δ mutant strain increased the tolerance of transformants to oligomycin. The plasmid‐borne Klpdr1‐1 allele increased the activation of the ScPDR5 promoter and complemented the drug hypersensitivity of the S. cerevisiae pdr1Δ pdr3Δ mutant strain. The results indicate that L273P amino acid substitution is the result of a gain‐of‐function mutation in the KlPDR1 gene that confers KlPdr1p hyperactivity, as revealed by a high expression of the ABC transporter gene KlPDR5, leading to multidrug resistance and rhodamine 6G efflux out of the cells. Copyright © 2013 John Wiley & Sons, Ltd.
Intra‐arterial Allogeneic Mesenchymal Stem Cells for Critical Limb Ischemia are Safe and Efficacious: Report of a Phase I Study
Authors: Das Anjan Kumar , Abdullah Basri Johan Jeet Bin , Dhillon S. S. , Vijanari A. , Anoop C. H. , Gupta Pawan Kumar 
Published: January 2013

AbstractBackgroundCritical limb ischemia (CLI) caused by peripheral arterial disease is associated with significant morbidity and mortality. This condition is associated with a 30 % amputation rate as well as mortality levels which might be as high as 25 %. There is no pharmacological therapy available, but several reports have suggested that mesenchymal stem cells (MSCs) may be a useful therapeutic option.MethodsThis study, done at a university hospital, evaluated 13 patients for a phase I trial to investigate the safety and efficacy of intra‐arterial MSCs in CLI patients. Eight patients with ten affected limbs were recruited for the study. As two patients (three limbs) died of ischemic cardiac events during the 6‐month follow‐up period, seven limbs were finally evaluated for the study.ResultsThere was significant pain relief. Visual analog scale (VAS) scores decreased from 2.29 ± 0.29 to 0.5 ± 0.34 (p < 0.05), ankle brachial pressure index (ABPI) increased significantly from 0.56 ± 0.02 to 0.67 ± 0.021 (p < 0.01), and transcutaneous oxygen pressure (TcPO2) also increased significantly in the foot from 13.57 ± 3.63 to 38 ± 3.47. Similar improvement was seen in the leg as well as the thigh. There was 86 % limb salvage and six of seven ulcers showed complete or partial healing.ConclusionIt was concluded that intra‐arterial MSCs could be safely administered to patients with CLI and was associated with significant therapeutic benefits.