bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cord blood methylation at TNFRSF17 is associated with early allergic phenotypes
Authors: Danielewicz Hanna , Gurgul Artur , Dębińska Anna , Drabik-Chamerska Anna , Hirnle Lidia , Boznański Andrzej 
Published: July 2024

AbstractFood allergy and eczema are the earliest allergic phenotypes in childhood. These diseases could be related to either IgE-mediated or non-IgE-mediated reactions to the allergen. TNFRSF17 is a key molecule in B cell maturation and is important in both types of responses.We conducted a study comparing the relative expression and the methylation status at the TNFRSF17 in regard to the child’s early atopic sensitisation and allergic phenotypes.In the recruited population of 200 women and 174 children with available clinical data (physical examination by allergist and antigen-specific IgE measurements), 78 cord blood samples were included in the gene expression analysis (relative gene expression with GAPDH as reference by RT-PCR) and 96 samples with microarray DNA methylation data (whole genome methylation profile Infinium MethylationEPIC).The altered TNFRSF17 methylation pattern in the cord blood at both single cg04453550 and mean methylation at upstream of TNFRSF17 was observed in children who developed food allergy and/or eczema in early childhood. The change in methylation profile was mirrored by the relative expression. The profile of IgE sensitisation to food and/or inhalant allergens was not significantly associated with either methylation or expression of TNFRSF17.In conclusion, methylation at the upstream sites at TNFRSF17 in the cord blood at birth is associated with food allergy and eczema early in childhood.
Further EU enlargement – a ‘brave new world’, or more like ‘back to the future’?
Authors: Sharpston Eleanor 
Published: July 2024

AbstractWill the challenges faced by both the European Union and a candidate country during a future enlargement process be ‘new’ challenges, or will they be reiterations of challenges successfully overcome during previous enlargements, notably during the ‘Big Enlargement 1.0’ in 2004? This contribution argues that many of the challenges (institutional, political, economic, legal, and linguistic) are indeed not new; but that a future EU enlargement is likely to take place within a far more uncomfortable global environment. In particular, the presence of a hostile and aggressive near neighbour in the shape of Russia will require a concerted and intelligent response.
The secret is quartz: technology of production of an eleventh-twelfth century western Mediterranean polychrome glazed ware
Authors: Salinas Elena , Pradell Trinitat 
Published: July 2024

AbstractA group of a well-known polychrome glazed ceramic, widespread in the western Mediterranean in the eleventh and first half of the twelfth centuries, has been analysed for the first time using Optical Microscopy (OM) and a Field Emission Scanning Electron Microscopy (FE-SEM) with Energy-Dispersive X-ray Spectroscopy (EDS), in order to shed some light on the materials, production technology and provenance, about which there are various hypotheses. This ware is characterised by a perfectly drawn and varied iconography, with often stylised zoomorphic and anthropomorphic and nautical motifs. It was produced in an as yet unidentified workshop in North Africa or the Iberian Peninsula. The pottery analysed was found in an archaeological excavation in the Barrio Andalusi of Almería (south-east of Spain). Technologically, the ceramics are fairly homogeneous, with copper-green and manganese-brown pigments applied over the raw tin glaze filled with large undissolved quartz particles. The use of quartz is consistent with a Fatimid-Zirid contribution from Ifriqiya, the use of tin is consistent with an Andalusi Umayyad-Taifas contribution, and the green and brown colours on a white ground to either Ifriqiya or Andalusi. Our study has shown that the use of quartz on the decorated glazed surface is not related to the need for an opacifier, but rather to the need for a highly viscous melt that limits the spread of the pigments during the firing allowing a finer and more detailed drawing. This fusion of different techniques has been identified for the first time. It is intriguing from the historical point of view of medieval technology, and provides the first insights into understanding the technological transfers and technical solutions that took place in the Mediterranean basin during this period.
The caregiving role influences Suboptimal Health Status and psychological symptoms in unpaid carers
Authors: Garcia Monique , Guo Zheng , Zheng Yulu , Wu Zhiyuan , Visser Ethan , Balmer Lois , Wang Wei 
Published: July 2024

Abstract
Background
Suboptimal Health Status (SHS) is the physical state between health and disease. This study aimed to fill in the knowledge gap by investigating the prevalence of SHS and psychological symptoms among unpaid carers and to identify SHS-risk factors from the perspective of predictive, preventive and personalised medicine (PPPM).

Methods
A cross-sectional study was conducted among 368 participants who were enrolled from Australia, including 203 unpaid carers as cases and 165 individuals from the general population as controls. SHS scores were measured using SHSQ-25 (Suboptimal Health Status Questionnaire-25), whilst psychological symptoms were measured by DASS-21 (Depression, Anxiety and Stress Scale-21). Chi-square was used to measure SHS and psychological symptom prevalence. Spearman correlation analysis was utilised to identify the relationship between SHSQ-25 and DASS-21 scores. Logistic regression analysis was used for multivariate analysis.

Results
The prevalence of SHS in carers was 43.0% (98/203), significantly higher than the prevalence 12.7% (21/165) in the general population (p < 0.001). In addition, suboptimal health prevalence was higher in female carers (50.3%; 95/189) than females in the general population (12.4%; 18/145). Logistic regression showed that the caregiving role influenced SHS, with carers 6.4 times more likely to suffer from SHS than their non-caring counterparts (aOR = 6.400, 95% CI = 3.751–10.919).

Conclusions
Unpaid carers in Australia have a significantly higher prevalence of SHS than that in the general population and experience poorer health. The SHSQ-25 is a powerful tool that can be utilised to screen at-risk individuals to predict their risk of chronic disease development, an essential pillar for shifting the paradigm change from reactive medicine to that of predictive, preventive and personalised medicine (PPPM).
Performance analysis and degradation mechanism of acrylamide co-polymer as rheology and filtrate reducers in different salt aqueous-based drilling mud systems at high-temperature conditions
Authors: Balaga Dileep Kumar , Mondal Jayanta , Kulkarni Sandeep D. 
Published: July 2024

AbstractTo maintain performance of an aqueous-based drilling muds (ABDMs), it was imperative to understand the decay mechanism of the incorporated synthetic polymers, when exposed to the elevated temperatures. The understanding of the decay mechanism could provide a polymer replenishment strategy for the fluid to retain a specific rheology and filtrate control performance. In this context, thermal-degradation of various acrylamide co-polymers was investigated in different monovalent brines. The acrylamide co-polymers were custom synthesized, and their molecular weight and % sulfonic substitution was verified using the capillary viscometer and nuclear magnetic resonance spectroscopy techniques respectively. The co-polymer thermal degradation mechanism (i.e., polymer hydrolysis) in various monovalent brines (KCl, NaCl and NaBr) was quantified by novel titration for temperature range {121 °C, 177 °C}. The degradation response of the co-polymers was then correlated with their rheology and HPHT (high-pressure-high-temperature) filtrate performance; for instance, the titration studies showed that co-polymer degradation was 12–15% and 44–47% after sixteen hours aging at 121 °C and 177 °C respectively; correspondingly the co-polymer performance in ABDM, exhibited HPHT filtrate of 12–18 mL and 38–40 mL at those respective temperatures after sixteen hours of aging. The quantified understanding of the co-polymer thermal degradation was used to device a new approach for co-polymer replenishment strategy; it was illustrated that a 7% replenishment of the co-polymer for every eight hours, at 121 °C, enabled sustained HPHT filtrate of 12–18 mL for the studied evaluation period of thirty-two hours. The replenishment approach presented in the study would provide a valuable tool for drilling automation to ensure sustained fluid performance.
Case Report. Desmopressine en alcohol: een levensbedreigende combinatie
Authors: Kil Nicoline M. P. , ten Donkelaar Celine S. , Wijn Rob P. W. F. , Veenboer Paul W. 
Published: July 2024

SamenvattingWe beschrijven een casus van een 22-jarige patiënt die door gebruik van desmopressine in combinatie met alcohol in comateuze toestand is opgenomen op de intensive care. Er was sprake van hersenoedeem door een diepe hyponatriëmie van 117 mmol/l. We gaan in op de verschillende oorzaken die hiertoe hebben geleid en op welke manier een dergelijk ernstig incident voorkomen kan worden.
Towards automatic phytolith classification using feature extraction and combination strategies
Authors: Díez-Pastor José-Francisco , Latorre-Carmona Pedro , Arnaiz-González Álvar , Canepa-Oneto Antonio , Ruiz-Pérez Javier , Zurro Débora 
Published: July 2024

AbstractPhytolith analysis is now an essential technique, both for the reconstruction of past environmental and climatic changes and for the study of anthropic and faunal plant use, in such disciplines as archaeology, paleoecology, paleonthology, and palynology. Currently, phytolith identification and categorisation involves time-consuming and tedious manual classification tasks that are not always error free. Automated phytolith classification will be key to the standardisation of phytolith identification processes, circumventing human error in the phytolith identification process. In this paper, a comparative analysis is presented of different types of feature sets, feature combinations, and classifier combinations (through stacking), and their use for automatic phytolith classification, including state-of-the-art vision transformers and convolutional neural networks, techniques which have shown remarkable progress within different areas, including computer vision. In this research, twenty-two different sets of features (three based on shape, sixteen on appearance, and three on texture) and six classifier strategies (single and combined via stacking) were compared. The experimental results revealed that texture-related features offered no valuable information for classification purposes. However, classification tasks were efficiently performed with strategies based on shape and appearance features (extracted using deep neural networks). More specifically, the use of those features combined with a stacking strategy, achieved better results than any other features and feature-based strategies, with an accuracy value of 98.32%.
Homoplasy as an Evolutionary Process: An Optimistic View on the Recurrence of Similarity in Evolution
Authors: de Santis Marcelo Domingos 
Published: July 2024

AbstractIn the cladistic literature, there is a recurrent perspective that considers homoplasy as something undesirable. Homoplasy, according to this view, is believed to obscure homologies that may lead to synapomorphies. Some cladists often call homoplasies an ad hoc hypothesis or an “error in our preliminary assignment of homology.” Consequently, homoplasy is generally regarded negatively, hindering further investigations, because it matters little whether a character subject to homoplasy is a convergence, a parallelism, or a reversal, since they all fall within the problematic homoplastic category. Nixon and Carpenter developed one of the recent arguments supporting this vision. In this context, I will argue that phylogenetics, being a part of evolutionary biology, must be compatible with its principles. Therefore, I will discuss the idea that homoplasy is more complex than just nonhomology, sometimes even constituting evidence of common ancestry (e.g., parallelism). I will put forward the thesis that it is crucial to differentiate instances of convergence, parallelism, and reversions by incorporating recent advances from EvoDevo research. Ultimately, this approach aims to demonstrate that evolutionary biology and phylogenetics mutually complement each other and assist in providing different lines of evidence that can be used to test different evolutionary hypotheses.
“If you cannot measure it, you cannot improve it”. Outcome measures in Duchenne Muscular Dystrophy: current and future perspectives
Authors: Benemei Silvia , Gatto Francesca , Boni Luca , Pane Marika 
Published: July 2024

AbstractDuchenne Muscular Dystrophy (DMD) is an X-linked recessive neuromuscular disorder primarily affecting males, caused by mutations in the dystrophin gene. The absence of dystrophin protein leads to progressive skeletal muscle degeneration. Recent advances in the therapeutic landscape underscore the need to identify appropriate outcome measures to assess treatment efficacy in ambulant and non-ambulant DMD patients, across clinical and research settings. This is essential for accurately evaluating new treatments and attributing therapeutic benefits.It is crucial to establish a robust correlation between outcome scores and disease progression patterns. This task is challenging since functional test performance may be influenced by different patient’s characteristics, including the physiological evolution of the neurodevelopment together with the disease progression. While widely used DMD outcomes such as the North Star Ambulatory Assessment, the 6-Minute Walking Test, the 4 stairs climbed, and the Performance of the Upper Limb exhibit reliability and validity, their clinical significance is influenced by the wide phenotype and progression variability of the disease.We present and discuss the features (relevance, quantifiability, validity, objectivity, reliability, sensitivity, specificity, precision) of available DMD outcome measures, including new potential measures that may be provided by digital tools and artificial intelligence.
Associations between patient portal use and electronic health record (EHR) data timeliness in type 2 diabetes mellitus care
Authors: Wiley Kevin , Blackburn Justin , Mendonca Eneida , Menachemi Nir , De Groot Mary , Vest Joshua R. 
Published: July 2024

Abstract
Objective
Patient data is subject to missingness and errors. Patient portals enable patients managing type 2 diabetes mellitus (T2DM) to review and correct data to avoid retesting, medication errors, and diagnostic mistakes. We examined whether patient portal use was associated with electronic health record (EHR) data timeliness in T2DM care.

Research Design and methods
We analyzed EHR data from a panel of adult patients to determine whether portal use improved data timeliness. EHR data timeliness is measured as the number of days between patient encounters, accounting for mean attribute update periods, where available EHR attribute updates for T2DM measurements were present, including body mass, weight, glycated hemoglobin A1c, cholesterol, blood pressure, serum creatinine, and smoking status. We performed negative binomial regressions with fixed effects to estimate the association between patient portal use and EHR data timeliness. Sensitivity analyses were conducted using Poisson regressions.

Results
Nearly a third (31.3%) of patients in our sample actively used the health portal. There were fewer days (111.9 days vs. 136.7 days; p < 0.001) between EHR attribute updates for patients who used health portals compared to patients who did not. Data timeliness was lower among female, non-Hispanic White Medicare beneficiaries. Based on regression analyses, portal use was associated with an expected 3.6 (p < 0.001) percentage point decrease in days between attribute updates, indicating improved EHR timeliness.

Conclusion
Improving the quality of health information may streamline decision-making in partnership with patients who produce data points across clinical settings. Active use of patient portals and digital health tools in chronic disease care are critical for care management and clinical decision-making, especially for patients managing type 2 diabetes across clinical settings.
Adaptive multi-stage evolutionary search for constrained multi-objective optimization
Authors: Li Huiting , Jin Yaochu , Cheng Ran 
Published: July 2024

AbstractIn this paper, we propose a multi-stage evolutionary framework with adaptive selection (MSEFAS) for efficiently handling constrained multi-objective optimization problems (CMOPs). MSEFAS has two stages of optimization in its early phase of evolutionary search: one stage that encourages promising infeasible solutions to approach the feasible region and increases diversity, and the other stage that enables the population to span large infeasible regions and accelerates convergence. To adaptively determine the execution order of these two stages in the early process, MSEFAS treats the optimization stage with higher validity of selected solutions as the first stage and the other as the second one. In addition, at the late phase of evolutionary search, MSEFAS introduces a third stage to efficiently handle the various characteristics of CMOPs by considering the relationship between the constrained Pareto fronts (CPF) and unconstrained Pareto fronts. We compare the proposed framework with eleven state-of-the-art constrained multi-objective evolutionary algorithms on 56 benchmark CMOPs. Our results demonstrate the effectiveness of the proposed framework in handling a wide range of CMOPs, showcasing its potential for solving complex optimization problems.
Mineral and fluid transformation of hydraulically fractured shale: case study of Caney Shale in Southern Oklahoma
Authors: Awejori Gabriel A. , Dong Wenming , Doughty Christine , Spycher Nicolas , Radonjic Mileva 
Published: July 2024

AbstractThis study explores the geochemical reactions that can cause permeability loss in hydraulically fractured reservoirs. The experiments involved the reaction of powdered-rock samples with produced brines in batch reactor system at temperature of 95 °C and atmospheric pressure for 7-days and 30-days respectively. Results show changes in mineralogy and chemistry of rock and fluid samples respectively, therefore confirming chemical reactions between the two during the experiments. The mineralogical changes of the rock included decreases of pyrite and feldspar content, whilst carbonate and illite content showed an initial stability and increase respectively before decreasing. Results from analyses of post-reaction fluids generally corroborate the results obtained from mineralogical analyses. Integrating the results obtained from both rocks and fluids reveal a complex trend of reactions between rock and fluid samples which is summarized as follows. Dissolution of pyrite by oxygenated fluid causes transient and localized acidity which triggers the dissolution of feldspar, carbonates, and other minerals susceptible to dissolution under acidic conditions. The dissolution of minerals releases high concentrations of ions, some of which subsequently precipitate secondary minerals. On the field scale, the formation of secondary minerals in the pores and flow paths of hydrocarbons can cause significant reduction in the permeability of the reservoir, which will culminate in rapid productivity decline. This study provides an understanding of the geochemical rock–fluid reactions that impact long term permeability of shale reservoirs.
Prediction technology of mine water inflow based on entropy weight method and multiple nonlinear regression theory and its application
Authors: Li Bo , Wu Huang , Wu Qiang , Zeng Yifan , Guo Xiaoming 
Published: July 2024

AbstractMine water inflow is an important basis for the formulation of mining plans and the utilization of groundwater resources. The mine water inflow is the result of the combined influence of many factors. The weight value of the influencing factors is calculated by the entropy method, and the order of importance of the factors is: precipitation > mining depth > cumulative mined-out area > aquifer thickness > mining area > mining height. The optimal univariate nonlinear regression model of mine water inflow to each influencing factor is obtained by factor scatter analysis and Matlab function programming. On this basis, combined with the weight values of factors, a multivariate nonlinear regression prediction model of mine water inflow based on weighting is innovatively established, which overcomes the defect that the traditional water inflow prediction method that cannot reflect the relative importance differences of various influencing factors. The multivariate weighted nonlinear regression model is used to predict the mine water inflow of typical coal mines, and the prediction results are compared with the linear regression model and the measured value. The results show that the prediction model of mine water inflow based on weighted multivariate nonlinear regression is accurate higher, with higher practical application value.
Shale gas potential evaluation based on well-logs and basin modeling of the Cretaceous-Paleocene succession of the Kohat Plateau, Pakistan: implication for shale gas exploration
Authors: Tahir Murad , Hanif Muhammad , Khan Sarfraz , Radwan Ahmed E. , Ullah Shuja 
Published: July 2024

AbstractThis study examines subsurface data from three wells to assess the shale gas potential of the Cretaceous-Paleocene succession of the Kohat Plateau, Pakistan. The petrophysical analysis was performed to calculate total organic carbon (TOC) using the Passey model. Petro-elastic parameters (Poisson ratio, Young modulus, and brittleness) and thermal maturity were also evaluated, respectively. The average TOC values in Makori-01 (as calculated by Passey's method) are 2.88 (wt%) for the Lockhart Limestone and 2.10 (wt%) for the Chichali-1 Formation. In Manzalai-02 well, the Lockhart, Hangu, Kawagarh, Lumshiwal, and Chichali formations TOC values are 2.81 (wt%), 2.55 (wt%), 2.32(wt%), 2.29 (wt%) and 2.20 (wt%) respectively. To exploit the unconventional resources, zones I and II in the Sumari Deep X-01 well (Chichali Formation) with an average TOC value of 2.71 (wt%) can be considered favorable areas for further evaluation. The volume of shale value is resulted as maximum within Chichali Formation in Makori-01 (58.52–75.89%), Manzalai-02 (54.09%), and Sumari Deep X-01 (70.47%), while the least value is noted within Lockhart Limestone in Makori-01 (12.25%) and Manzalai-02 (14.02%), and in Hangu Formation in Sumari Deep X-01 (12.39%). Also, the elastic properties reveal two to four zones of Young modulus, brittleness index, and Poisson’s ratio within the Chichali Formation in the studied three wells. The isopach maps show that the Patala, Lockhart, Hangu, Lumshiwal, and Chichali formations in the research area exhibit variable thicknesses. The 1D maturity models of the Makori-01 and Manzalai-02 wells indicate burial to a depth of 8 km approximately 2.5 Ma ago and the apex of oil production (1.1% Ro). The 1D maturity models indicate that the Sumari Deep X-01 well has encountered minimal burial (in terms of both time and depth) and, as a result, exhibits minimal potential source rock intervals. The volumetric estimate of unconventional recoverable gas resources is approximately 1.57 TCF in the study area. The integrated research provides the basis for tracking and assessing the unconventional resource potential, distribution, and characteristics within the studied basin.