bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: One‐Pot Synthesis of Fully Substituted Pyrimidines Using Amidine and Ketene Dithioacetals as Synthons and Their Antimicrobial Activity.
Authors: Gami Sagar P. , Kathrotiya Haresh G. , Naliapara Yogesh T. 
Published: August 2015

AbstractSome of the title pyrimidines (III) display excellent antimicrobial activity similar to the standard drug ampicillin.
ChemInform Abstract: Synthesis of Some New Derivatives of Thiazolopyrimidines and Hydrolysis of Its Arylidene Derivative.
Authors: Nagarajaiah H. , Khazi Imtiyaz Ahmed M. , Begum Noor Shahina 
Published: August 2015

AbstractThe synthesis of a variety of new derivatives of thiazolopyrimidine including tricyclic compound (XX) and some arylidene derivatives (III) is described.
ChemInform Abstract: Synthesis of Condensed Heterocycles by the Gould—Jacobs Reaction in a Novel Three‐Mode Pyrolysis Reactor.
Authors: Lengyel Laszlo Csaba , Sipos Gellert , Sipocz Tamas , Vago Terez , Dorman Gyoergy , Gerencser Janos , Makara Gergely , Darvas Ferenc 
Published: August 2015

AbstractThe synthesis of a series of fused pyrimidine heterocycles (including some novel ones) via Gould‐Jacobs reactions using an in‐house‐built vacuum‐to‐high pressure multipurpose pyrolysis reactor is described.
ChemInform Abstract: Synthesis of 1,2‐Borazaronaphthalenes from Imines by Base‐Promoted Borylation of C—H Bond.
Authors: Liu Xinwang , Wu Pengbo , Li Jianfeng , Cui Chunming 
Published: August 2015

AbstractA convenient and reliable base‐promoted borylation route to synthesize novel 1,2‐borazaronaphthalenes starting from easily available imines under mild conditions is presented.
ChemInform Abstract: Selective Synthesis of Alkylboronates by Copper(I)‐Catalyzed Borylation of Allyl or Vinyl Arenes.
Authors: Wen Yanmei , Xie Jianying , Deng Chunmei , Li Chaode 
Published: August 2015

AbstractThe reaction follows Markovnikov fashion in the case of allylarenes while in the case of styryl derivatives, anti‐Markovnikov products are preferentially formed.
ChemInform Abstract: Synthesis of Lipid‐Based Unsymmetrical O,O‐Dialkylphosphites.
Authors: Berchel Mathieu , Haddad Jimmy , Le Corre Stephanie S. , Haelters Jean‐Pierre , Jaffres Paul‐Alain 
Published: August 2015

AbstractThe title reaction implies the use of H‐phosphonate monoester ammonium salts (I) which are coupled with fatty alcohols (II) in the presence of pivaloyl chloride as coupling reagent.
ChemInform Abstract: Reaction of Lawesson′s Reagent with γ‐Phosphonyloximes: Synthesis of Novel 1,2,5‐Oxazaphospholine Derivatives.
Authors: Touil Soufiane , Wahbi Aymen 
Published: August 2015

AbstractTitle compounds [(IV) and (VII)] are regioselectively synthesized by a simple and efficient methodology which gives mixtures of two inseparable diastereomers.
ChemInform Abstract: An Efficient Solventless Synthesis of Cycloalkeno‐1,2,3‐selenadiazoles, Their Antimicrobial Studies, and Comparison with Parent Semicarbazones.
Authors: Jadhav Aditi A. , Dhanwe Vaishali P. , Joshi Prasad G. , Khanna Pawan K. 
Published: August 2015

AbstractAll new compounds (II) possess antimicrobial activities against Escherichia coli, Staphylococcus aureus and Salmonella typhi, with compound (IIa) showing activity also against highly resistant Pseudomonas aeruginosa.
ChemInform Abstract: Bioactive 18(4 → 3)‐abeo‐Abietanoid Derivatives from the Leaves of Tripterygium wilfordii.
Authors: Wang Chao , Li Chuang‐Jun , Ma Jie , Yang Jing‐Zhi , Chen Xiao‐Guang , Li Li , Zhang Dong‐Ming 
Published: August 2015

AbstractThe isolation and structure elucidation of new tripterlides A‐F, (I) ‐ (VI), is presented.
ChemInform Abstract: Stereochemical Determination of the Leupyrrins and Total Synthesis of Leupyrrin A1.
Authors: Herkommer Daniel , Thiede Sebastian , Wosniok Paul R. , Dreisigacker Sandra , Tian Maoqun , Debnar Thomas , Irschik Herbert , Menche Dirk 
Published: August 2015

AbstractThe relative and absolute configurations of potent antifungal agents leupyrrin A1 (I) and B1 (II) are determined by a combination of high field NMR studies, molecular modeling, and chemical derivatization.
ChemInform Abstract: Facile and Efficient Exfoliation of Inorganic Layered Materials Using Liquid Alkali Metal Alloys.
Authors: Feng Hongbin , Hu Zhongbo , Liu Xiangfeng 
Published: August 2015

AbstractSingle‐ and few‐layer MoS2, WS2, and BN nanosheets are prepared through intercalation and exfoliation using liquid NaK or NaLi alkali metal alloys in DME at room temperature for 24—48 h.
ChemInform Abstract: Recent Advances in Gold and Silver Nanoparticles: Synthesis and Applications
Authors: Majdalawieh Amin , Kanan Marsha C. , El‐Kadri Oussama , Kanan Sofian M. 
Published: August 2015

AbstractReview: various synthetic methods; applications also including biosensing, diagnostic imaging, and cancer diagnosis and therapy besides the more common applications such as catalysis; 405 refs.
ChemInform Abstract: Mechanistic Basis for Regioselection and Regiodivergence in Nickel‐Catalyzed Reductive Couplings
Authors: Jackson Evan P. , Malik Hasnain A. , Sormunen Grant J. , Baxter Ryan D. , Liu Peng , Wang Hengbin , Shareef Abdur‐Rafay , Montgomery John 
Published: August 2015

AbstractReview: 43 refs.
Mechanism of Incompatible Herb Pairs, Panax ginseng and Veratrum nigrum L.: Material Basis and Metabolic Profiles of Ginsenosides in Rat Intestinal Bacteria
Authors: Yang Xiudong , Li Xue , Xu Ying , Pi Zifeng , Lin Na , Liu Zhiqiang , Song Fengrui 
Published: August 2015

AbstractIn traditional Chinese medicine theory, Panax ginseng and Veratrum nigrum L. is an important incompatible herb pair. Studies on the content variation of main components and the influences on the metabolism in rat intestinal bacteria are useful to understand the mechanism of incompatibility of this herb pairs. In this study, the content variation of ginsenosides and their metaboltic profiles in the extracts of P. ginseng and compatibility of P. ginseng with V. nigrum L. (G‐V) were investigated using relative quantitative method of electrospray ionization mass spectrometry (ESI‐MS) and UPLC‐MSn, respectively. The relative contents of most ginsenosides were reduced in the extract of G‐V. Furthermore, ginsenosides Rb1, Rb2, Rc and Rd could be metabolized to Rd, F2 and C‐K in rat intestinal bacteria. The metabolic speeds of Rb1, Rb2 and Rc in the G‐V extracts at ratios of 10:5, 10:7 and 10:10 and the metabolic rates of ginsenosides Rb1, Rb2 and Rc to Rd, Rd to F2 in all compatibility extracts were lower than that in the P. ginseng extract. In conclusion, this study illustrated the mechanism of effect‐reducing by comparison of the relative contents and metabolic profiles of ginsenosides after compatibility of P. ginseng and V. nigrum L.
Chitin‐Derived Mesoporous, Nitrogen‐Containing Carbon for Heavy‐Metal Removal and Styrene Epoxidation
Authors: Gao Yongjun , Chen Xi , Zhang Jiaguang , Yan Ning 
Published: August 2015

AbstractThe production of a series of mesoporous, nitrogen‐containing (N‐containing) carbon materials directly from pure chitin by means of carbonization at different temperatures under template‐free conditions is reported. Thermogravimetric analysis combined with infrared spectroscopy was applied to follow the temperature‐dependent chemical events during the carbonization process, thereby shedding light on the automated pore formation mechanism. The physicochemical properties of the N‐containing carbon materials have been extensively investigated, which provided guidance and rational understanding of the application of these materials. It was found that the N‐containing carbon materials obtained at lower temperatures (400–600 °C) were enriched with amine, amide, and pyrrolic functionalities, which enables their very high efficiency as adsorbents to remove toxic heavy metals, such as CrVI, HgII, and PdII, from water. In contrast, N‐containing carbon materials prepared at higher temperatures (800–1000 °C) were enriched with graphitic N, which exhibited excellent catalytic activity in the epoxidation of styrene.
American pika in a low‐elevation lava landscape: expanding the known distribution of a temperature‐sensitive species
Authors: Shinderman Matt 
Published: August 2015

AbstractIn 2010, the American pika (Ochotona princeps fenisex) was denied federal protection based on limited evidence of persistence in low‐elevation environments. Studies in nonalpine areas have been limited to relatively few environments, and it is unclear whether patterns observed elsewhere (e.g., Bodie, CA) represent other nonalpine habitats. This study was designed to establish pika presence in a new location, determine distribution within the surveyed area, and evaluate influences of elevation, vegetation, lava complexity, and distance to habitat edge on pika site occupancy. In 2011 and 2012, we conducted surveys for American pika on four distinct subalpine lava flows of Newberry National Volcanic Monument, Oregon, USA. Field surveys were conducted at predetermined locations within lava flows via silent observation and active searching for pika sign. Site habitat characteristics were included as predictors of occupancy in multinomial regression models. Above and belowground temperatures were recorded at a subsample of pika detection sites. Pika were detected in 26% (2011) and 19% (2012) of survey plots. Seventy‐four pika were detected outside survey plot boundaries. Lava complexity was the strongest predictor of pika occurrence, where pika were up to seven times more likely to occur in the most complicated lava formations. Pika were two times more likely to occur with increasing elevation, although they were found at all elevations in the study area. This study expands the known distribution of the species and provides additional evidence for persistence in nonalpine habitats. Results partially support the predictive occupancy model developed for pika at Craters of the Moon National Monument, another lava environment. Characteristics of the lava environment clearly influence pika site occupancy, but habitat variables reported as important in other studies were inconclusive here. Further work is needed to gain a better understanding of the species’ current distribution and ability to persist under future climate conditions.
Bioinspired Fluorescent Dyes Based on a Conformationally Locked Chromophore of the Fluorescent Protein Kaede
Authors: Baleeva Nadezhda S. , Myannik Ksenia A. , Yampolsky Ilia V. , Baranov Mikhail S. 
Published: August 2015

AbstractA novel class of fluorescent dyes based on the conformationally locked heterocyclic core of the chromophore of the fluorescent protein Kaede was discovered. Introduction of a single conformational lock at the benzylidene fragment of the Kaede chromophore resulted in an increase in the fluorescence quantum yield (FQY) by one order of magnitude and a redshift of ca. 60 nm in the emission spectrum. Imposing the second lock at the ethylene fragment of the Kaede chromophore provided a further increase in the FQY. Locked analogues demonstrated bright and redshifted emission in a broad range of solvents, which makes them good candidates for a wide spectrum of fluorescent‐labeling applications.
Synthesis of P‐Stereogenic Phosphoramidite and Phosphorodiamidite Ligands and Their Application in Asymmetric Catalysis
Authors: Schmitz Christian , Leitner Walter , Franciò Giancarlo 
Published: August 2015

AbstractA series of P‐stereogenic monodentate phosphoramidite (PNO2) and phosphorodiamidite (PN2O) ligands based on chiral Betti bases has been prepared by modular synthetic procedures. The chirality at the phosphorus can be controlled to a large extent by the synthetic route, leading to stereoselective access to single P‐epimers. The absolute configuration of the P‐atom was assigned by X‐ray diffraction analysis. The new ligands were evaluated in asymmetric catalysis and the influence of the exocyclic amine or alcohol moiety as well as the interplay between the P‐chirality and the stereocenters in the backbone were investigated. Enantioselectivities of up to 85 and 83 % ee were obtained in the Rh‐catalyzed hydrogenation of dimethyl itaconate and in the Pd‐catalyzed allylic amination of (rac)‐(E)‐1,3‐diphenylallyl acetate with benzylamine, respectively. In the Ni‐catalyzed hydrovinylation of styrene, ee values of up to 68 %, excellent chemoselectivities, and high activities (TOFav up to 3000 h–1) were achieved.
The circular relationship between matrix metalloproteinase‐9 and inflammation following myocardial infarction
Authors: Deleon‐Pennell Kristine Y. , Altara Raffaele , Yabluchanskiy Andriy , Modesti Alessandra , Lindsey Merry L. 
Published: August 2015

AbstractMatrix metalloproteinase‐9 (MMP‐9) regulates remodeling of the left ventricle after myocardial infarction (MI) and is tightly linked to the inflammatory response. The inflammatory response serves to recruit leukocytes as part of the wound healing reaction to the MI injury, and infiltrated leukocytes produce cytokines and chemokines that stimulate MMP‐9 production and release. In turn, MMP‐9 proteolyzes cytokines and chemokines. Although in most cases, MMP‐9 cleavage of the cytokine or chemokine substrate serves to increase activity, there are cases where cleavage results in reduced activity. Global MMP‐9 deletion in mouse MI models has proven beneficial, suggesting inhibition of some aspects of MMP‐9 activity may be valuable for clinical use. At the same time, overexpression of MMP‐9 in macrophages has also proven beneficial, indicating that we still do not fully understand the complexity of MMP‐9 mechanisms of action. In this review, we summarize the cycle of MMP‐9 effects on cytokine production and cleavage to regulate leukocyte functions. Although we use MI as the example process, similar events occur in other inflammatory and wound healing conditions. © 2015 IUBMB Life, 67(8):611–618, 2015
Microbial eukaryotic diversity and distribution in a river plume and cyclonic eddy‐influenced ecosystem in the South China Sea
Authors: Wu Wenxue , Wang Lei , Liao Yu , Huang Bangqin 
Published: August 2015

AbstractTo evaluate microbial eukaryotic diversity and distribution in mesoscale processes, we investigated 18S rDNA diversity in a river plume and cyclonic eddy‐influenced ecosystem in the southwestern South China Sea (SCS). Restriction fragment length polymorphism analysis was carried out using multiple primer sets. Relative to a wide range of previous similar studies, we observed a significantly higher proportion of sequences of pigmented taxa. Among the photosynthetic groups, Haptophyta accounted for 27.7% of the sequenced clones, which belonged primarily to Prymnesiophyceae. Unexpectedly, five operational taxonomic units of Cryptophyta were closely related to freshwater species. The Chlorophyta mostly fell within the Prasinophyceae, which was comprised of six clades, including Clade III, which is detected in the SCS for the first time in this study. Among the photosynthetic stramenopiles, Chrysophyceae was the most diverse taxon, which included seven clades. The majority of 18S rDNA sequences affiliated with the Dictyochophyceae, Eustigmatophyceae, and Pelagophyceae were closely related to those of pure cultures. The results of redundancy analysis and the permutation Mantel test based on unweighted UniFrac distances, conducted for spatial analyses of the Haptophyta subclades suggested that the Mekong River plume and cyclonic eddy play important roles in regulating microbial eukaryotic diversity and distribution in the southwestern SCS.
In vivo magnetization transfer imaging of the lung using a zero echo time sequence at 4.7 Tesla in mice: Initial experience
Authors: Wurnig Moritz C. , Weiger Markus , Wu Mingming , Kenkel David , Jungraithmayr Wolfgang , Pruessmann Klaas P. , Boss Andreas 
Published: August 2015

PurposeThe aim of the present study was to assess the feasibility of magnetization transfer‐prepared zero echo time (ZTE) imaging of the lung in vivo at high field strength [4.7 Tesla) T] in mice.MethodsEighteen C57BL/10 mice underwent MRI examinations in a 4.7T MR‐scanner. A three‐dimensional ZTE sequence was applied for lung imaging combined with a Gaussian MT‐prepulse, which was followed by a train of 100 ZTE imaging readouts. Degree of MT was assessed by calculation of the magnetization transfer ratio (MTR). Direct saturation was estimated using Bloch equation simulations based on T1 measurements. The line‐width of pulmonary tissue was estimated using T2* measurements.ResultsExperimental MTR‐values of nonpulmonary tissues obtained with ZTE exhibited the characteristics known from conventional MT‐sequences (skeletal muscle and liver: high values; fatty tissue: low values). Lung tissue demonstrated MTR‐values in between fatty tissue and liver tissue. Direct saturation could be estimated by the Bloch simulation; however, an adequate approximation was only possible for T2 values nearly in the range of parenchymal organs.ConclusionPulmonary MT measurements at high field strength using the proposed MT‐ZTE sequence is feasible; however, estimation of direct saturation remains challenging. Magn Reson Med 76:156–162, 2016. © 2015 Wiley Periodicals, Inc.
Preparation, Properties, and Reactivity of (Aminoferrocenyl)(ferrocenyl)carbene(pentacarbonyl)chromium(0) as Bulky Isolobal Trimetallo‐amide
Authors: Veit Philipp , Förster Christoph , Seibert Sebastian , Heinze Katja 
Published: August 2015

AbstractNucleophilic substitution of the ethoxy substituent in the Fischer carbene complex (ethoxy)(ferrocenyl)carbene(pentacarbonyl)chromium(0) (1) by ferrocenyl amide [Fc‐NH]– [2‐H]– gives the hetero trimetallic complex (aminoferrocenyl)(ferrocenyl)carbene (pentacarbonyl)chromium(0) (3). As the Cr(CO)5 fragment is isolobal to oxygen or sulfur 3 can be viewed as an isolobal metallo analogue to diferrocenylamide (Fc)(FcNH)C=O (4) and diferrocenylthioamide (Fc)(FcNH)C=S (5). The impact of the formal replacement of O/S by Cr(CO)5 in 3 is studied with respect to steric and electronic consequences as well as reactivity by spectroscopic, diffraction, electrochemical and theoretical methods.
Laparoscopic Versus Open Loop Ileostomy Reversal: Is there an Advantage to a Minimally Invasive Approach?
Authors: Young Monica T. , Hwang Grace S. , Menon Gopal , Feldmann Timothy F. , Jafari Mehraneh D. , Jafari Fariba , Perez Eden , Pigazzi Alessio 
Published: August 2015

AbstractBackgroundIleostomy reversals are commonly performed procedures after colon and rectal operations. Laparoscopic ileostomy reversal (LIR) with lysis of adhesions has potential benefits over conventional open surgery. The aim of this study was to compare outcomes of laparoscopic and open ileostomy reversal.Methods133 consecutive patients undergoing ileostomy reversal at our institution between June 2009 and August 2013 were analyzed using a retrospective database. The group comprised 53 laparoscopic cases and 80 open cases, performed by four surgeons at a single center. The data were analyzed for patient demographics, operative characteristics, postoperative outcomes, and 30‐day morbidity and mortality.ResultsThe two groups had comparable mean age, gender distribution, ASA scores, and BMI. The laparoscopic group had a significantly longer duration of surgery compared to the open reversal group (109 versus 93 min, p < 0.05). However, this group underwent more lysis of adhesions (60.4 % versus 26.3 %, p < 0.01) as well as concurrent stoma site mesh reinforcement (32.1 % versus 6.3 %, p < 0.01). In the laparoscopy group, 20.7 % of patients underwent intra‐corporeal ileo‐ileal anastomosis. There were no significant differences between the laparoscopic and open groups with regard to estimated blood loss (31 versus 40 ml, respectively) or mean length of stay (5.3 vs. 5.7 days, respectively). The rates of overall 30‐day morbidity (16.9 % for laparoscopic vs. 21.3 % for open) as well as rates of specific complications were equivalent between groups. 30‐day mortalities were not noted in either group.ConclusionLIR is safe and effective with low perioperative morbidity and mortality. The use of laparoscopy as an option in terms of concomitant hernia repair and lysis of adhesions may be considered in selected patients.
Effect of Chain Length on the Micellization, Antibacterial, DPPC Interaction and Antioxidant Activities of l‐3,4‐Dihydroxyphenylalanine (l‐DOPA) Esters
Authors: Joondan Nausheen , Jhaumeer‐Laulloo Sabina , Caumul Prakashanand 
Published: August 2015

Abstractl‐DOPA (l‐3,4‐dihydroxyphenylalanine) has been widely used as a drug in the clinical treatment of Parkinson's disease. In this report, the systematic study of the effect of chain length on the critical micelle concentration (CMC), antibacterial and antioxidant activity of esters derived from the aromatic amino acid l‐3,4‐dihydroxyphenylalanine as surfactants are accounted for the first time. The antibacterial activity displayed a cut‐off effect at C12 with respect to both gram positive and gram negative bacteria (except for Pseudomonas aeruginosa where the cut‐off was displayed at C10). Correlation of the CMC with the minimum inhibitory concentration (MIC) shows that the DOPA esters exist in micellar form at the MIC. An increase in chain length of the DOPA esters induces greater binding with phospholipid vesicles 1,2‐dipalmitoyl‐sn‐glycero‐3‐phosphocholine. The C12 ester possessed highest radical scavenging ability among the esters tested against both 2,2‐diphenyl‐1‐picrylhydrazyl and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulphonic acid) showing that antioxidant activity of the DOPA esters is also affected by chain length. This study showed that DOPA esters are promising candidates as antibacterial agents as well as good antioxidants.
Feature curve extraction from point clouds via developable strip intersection
Authors: Lee Kai Wah , Bo Pengbo 
Published: August 2015

Abstract
In this paper, we study the problem of computing smooth feature curves from CAD type point clouds models. The proposed method reconstructs feature curves from the intersections of developable strip pairs which approximate the regions along both sides of the features. The generation of developable surfaces is based on a linear approximation of the given point cloud through a variational shape approximation approach. A line segment sequencing algorithm is proposed for collecting feature line segments into different feature sequences as well as sequential groups of data points. A developable surface approximation procedure is employed to refine incident approximation planes of data points into developable strips. Some experimental results are included to demonstrate the performance of the proposed method.
Associations of diet quality with cognition in children – the Physical Activity and Nutrition in Children Study
Authors: Haapala Eero A. , Eloranta Aino-Maija , Venäläinen Taisa , Schwab Ursula , Lindi Virpi , Lakka Timo A. 
Published: August 2015

Evidence on the associations of dietary patterns with cognition in children is limited. Therefore, we investigated the associations of the Baltic Sea Diet Score (BSDS) and the Dietary Approaches to Stop Hypertension (DASH) score with cognition in children. The present cross-sectional study sample included 428 children aged 6–8 years (216 boys and 212 girls). The BSDS and the DASH score were calculated using data from 4 d food records, higher scores indicating better diet quality. Cognition was assessed by the Raven's Coloured Progressive Matrices (CPM) score, a higher score indicating better cognition. Among all children, the BSDS (standardised regression coefficient β = 0·122,P =0·012) and the DASH score (β = 0·121,P =0·015) were directly associated with the Raven's CPM score. Among boys, a lower BSDS (β = 0·244,P< 0·001) and a lower DASH score (β = 0·202,P= 0·003) were related to a lower Raven's CPM score. Boys in the lowest quartile of the BSDS (22·5v. 25·3,P= 0·029) and the DASH score (22·4v. 25·7,P= 0·008) had a lower Raven's CPM score than those in the highest quartile of the corresponding score. Among girls, the BSDS or the DASH score were not associated with cognition. In conclusion, a poorer diet quality was associated with worse cognition in children, and the relationship was stronger in boys than in girls.