bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of mechanical properties of aneurysms and intraluminal thrombus on abdominal aortic aneurysm aoutcomes
Authors: Caruso Gaia , Martínez Miguel Ángel , Peña Estefanía 
Published: February 2025

Abstract
This study aims to examine how changes in material coefficients impact the mechanical responses of AAA models, including both cases with and without the ILT. The main focus will be on identifying the material coefficients that most significantly influence strain and stress fields, using the GHO model, which is widely regarded as the most popular hyperelastic model. The findings of this study reveal that compliant AAAs are particularly sensitive to fiber dispersion, which exerts a substantial influence on stress distribution and deformation patterns. In stiffer AAAs, however, matrix stiffness emerges as the key player. Notably, the study of interactions among all GHO parameters demonstrate that even minor adjustments can dramatically shift model behavior, emphasizing the importance of finely fitted parameter combinations for accurate predictions. The impact of ILT material properties on AAA mechanical behavior was found to be relatively minor, indicating that precise fitting of ILT coefficients may not be essential. However, the inclusion of the ILT itself was important, as it played a crucial role in shielding the AAA wall by reducing stress. This study offers valuable insights into the material modeling of AAA tissue and the significance of the ILT. The findings can be instrumental in optimizing patient-specific computational models, enhancing the accuracy of AAA wall material behavior, while also incorporating the ILT’s effects.
Inversion of impact-echo data using a shape optimization approach
Authors: Commandeur Colin , Stolk Christiaan C. , Sprik Rudolf , Louwerse Gerard 
Published: February 2025

Abstract
For the thickness measurement of refractory structures, the impact-echo measurement is one of the methods being used. This method is especially suited for the cases where high frequencies cannot be used due to the high damping and scattering in the materials. The data gathered with this method are often processed using a one-dimensional approach, which works well for simple layered structures. However, when the geometry is more complex, the thickness of the material needs to be estimated, as well as the shape of the interface. In this paper a method for inversion of impact-echo data in a two-dimensional setting is presented using multiple transducers. The algorithm was implemented using Fenics finite element software. The software is used to solve the elastic wave equation and the dolfin-adjoint toolbox is used for efficient computation of the shape gradient. In the paper, the algorithm is tested on two common erosion profiles. These examples show that, under reasonable initial assumptions, the solution converges close to the shape of the true interface. In practice, it is convenient to use a low number of sensors; for the two cases, a numerical experiment is carried out to determine the minimum number of sources required to arrive at a good result. The robustness of the algorithm is tested by adding roughness to the interface and by superimposing noise on the reference signals. The last experiment investigates how the solutions change as the number of samples increases.
Pharmacy-led interventions to reverse and prevent prescribing cascades in primary care: a proof-of-concept study
Authors: Mohammad Atiya K. , Hugtenburg Jacqueline G. , Ceylan Yildiz , Kooij Marcel , Knies Saskia , van den Bemt Patricia M. L. A. , Denig Petra , Karapinar-Carkıt Fatma 
Published: February 2025

Abstract

Background
Prescribing cascades occur in clinical practice when a medication causes an adverse drug reaction (ADR), which is addressed by prescribing additional medication.

Aim
The aim was to provide proof-of-concept for pharmacy-led interventions to reverse or prevent prescribing cascades.

Method
Two community pharmacies each tested two approaches. To reverse prescribing cascades, ten cascades were selected from literature. Dispensing records were screened to identify patients with these cascades. To prevent prescribing cascades, patients who started medications associated with five of these cascades were telephoned one month after their first dispensing to discuss ADRs. Pharmacists assessed the need to intervene together with prescribers. Primary outcome was the proportion of patients with a treatment change initiated. Secondary outcomes were time investment, potential cost-savings, and pharmacists’ experiences.

Results
To reverse prescribing cascades, 24 patients were included. For eight the prescriber was consulted, resulting in the reversal of three cascades. Forty-four patients were included to prevent prescribing cascades. Six of them experienced an ADR that could lead to a prescribing cascade. For two patients interventions were conducted to prevent this. The estimated time investment to identify patients possibly in need of intervention was 4.5 h for the reversing approach and 4.8 h for the preventing approach, while follow-up actions required 1.8 h and 0.5 h, respectively. Both approaches could be cost-saving. Pharmacists considered both approaches relevant but identified a knowledge gap on how to intervene for some cascades.

Conclusion
Pharmacy-led interventions may reverse and prevent prescribing cascades, but more efficient screening methods and tools are needed before further implementation.
Defining polypharmacy in older adults: a cross-sectional comparison of prevalence estimates calculated according to active ingredient and unique product counts
Authors: Lee Georgie B. , Hosking Sarah M. , Etherton-Beer Christopher , Pasco Julie A. , Williams Lana J. , Holloway-Kew Kara L. , Page Amy T. 
Published: February 2025

Abstract

Background
Polypharmacy is common in older adults and may be associated with poor outcomes. However, methods used to define polypharmacy are rarely reported precisely, with potential implications for polypharmacy exposure estimates.

Aim
The aim was to investigate prevalence estimates according to different methods in an Australian population-based sample of older adults.

Method
This cross-sectional study included 735 adults aged ≥ 60 years participating in the Geelong Osteoporosis Study. Current prescription, non-prescription and complementary and alternative medicines were self-reported. Counting methods included the number of active ingredients and unique products. Polypharmacy and hyperpolypharmacy were determined using ≥ 5 and ≥ 10 medicine cut points respectively. Prevalence was estimated using ingredient- and product-level counts according to criteria defined by medicine schedule and type (i.e. scheduled prescription, non-prescription). Non-parametric testing measured differences between counting methods, univariate logistic regressions investigated disagreement between total counts and polypharmacy exposure.

Results
Polypharmacy prevalence (scheduled prescription medicines) was 30.3% and 35.9% (products versus ingredients). Prevalence increased to 52.8% and 57.3% when counts considered any medicine. Adults aged ≥ 80 years were most likely to use prescription combination products (OR 2.22 [95% CI 1.46, 3.35] p < 0.01), however, age was not associated with disagreement between product and ingredient polypharmacy exposure. Being male was associated with both prescription combination product use (OR 1.79 [95% CI 1.29, 2.47] p < 0.001) and disagreement between polypharmacy exposures (OR 2.29 [95% CI 1.15, 4.47] p=0.02).

Conclusion
Polypharmacy prevalence estimates varied substantially depending on the method applied. These data indicate the need for standardised reporting specific to medicines data and polypharmacy measures.
A Note on Nonlinear Critical Problems Involving the Grushin Subelliptic Operator: Bifurcation and Multiplicity Results
Authors: Molica Bisci Giovanni , Malanchini Paolo , Secchi Simone 
Published: February 2025

Abstract
We consider the boundary value problem

$$\begin{aligned} {\left\{ \begin{array}{ll} -\varDelta _\gamma u = \lambda u + \left| u \right| ^{2^*_\gamma -2}u ~& \text {in}~ \Omega \\ u = 0 ~& \text {on}~ \partial \Omega , \end{array}\right. } \end{aligned}$$

-

Δ
γ

u
=
λ
u
+

u

2
γ
∗

-
2

u

in

Ω

u
=
0

on

∂
Ω
,

where

$$\lambda >0$$

λ
>
0

,

$$\Omega $$

Ω

is an open bounded domain in

$$\mathbb {R}^N$$

R

N

,

$$N \ge 3$$

N
≥
3

, with

$$0\in \overline{\Omega }$$

0
∈

Ω
¯

, while

$$\varDelta _\gamma $$

Δ
γ

is the Grushin operator

$$\begin{aligned} \varDelta _ \gamma u(z) = \varDelta _x u(z) + | x |^{2\gamma } \varDelta _y u (z) \quad (\gamma \ge 0). \end{aligned}$$

Δ
γ

u

(
z
)

=

Δ
x

u

(
z
)

+

|
x
|

2
γ

Δ
y

u

(
z
)

(
γ
≥
0
)

.

We prove a multiplicity and bifurcation result for this problem, extending the results of Cerami, Fortunato and Struwe in [7] and of Fiscella, Molica Bisci and Servadei in [10].
Patients’ experiences with the routine use of a clinical feedback system prior to consultations in ostomy care: a qualitative study
Authors: Juvik Lill Anette , Andersen John Roger , Indrebø Kisten Lerum , Sandvoll Anne Marie 
Published: February 2025

Abstract

Purpose
Ostomy surgery involves significant bodily changes, and the adjustment process encompasses a broad spectrum of physical and psychosocial challenges. A clinical feedback system (CFS) has been developed to collect patient-reported outcomes as part of routine outpatient follow-up, reviewed by stoma care nurses, to better address patients’ needs during their adjustment process. The intervention appears promising; however, empirical evidence supporting its benefits remains limited. Thus, we explored patients’ experiences with the routine use of the CFS prior to consultations in ostomy care.

Methods
A qualitative design involved 27 semi-structured individual interviews with patients using CFS as part of routine care. The data were analysed using Braun and Clarke’s reflexive approach to thematic analysis.

Results
The overarching theme CFS—a tool with potential and multiple mechanisms of action was developed with three themes: (1) Grasping the purpose can be challenging, (2) Preparatory learning—triggering reflection and self-awareness, and (3) Means of communication and potential for being understood. Engaging with the CFS had personal utility value with many dimensions, varying in strength and significance for each patient. Even though not everyone grasped the purpose of its use, it was part of a preparatory learning process for consultations and the adjustment process itself. It triggered reflection and self-awareness and served as a means of communication with potential for follow-up.

Conclusion
Although the CFS appears promising, future research should focus on identifying the most effective methods for educating patients on its use.
Enhancing disciplinary literacy through integrated writing and process instruction: an intervention study
Authors: Holdinga Lieke , van Drie Jannet , Rijlaarsdam Gert 
Published: February 2025

Abstract
Writing activities can be powerful tools for learning, linking literacy with content knowledge to build students’ disciplinary literacy. However, students are relatively unexperienced writers who benefit from teacher support to balance literacy with content goals. This study evaluated a brief, flexible writing intervention designed to help students in grades 10–12 improve their disciplinary writing in the specific domain of history. Conducted with 14 classes across 10 schools, the study used a pretest–posttest design to assess effectiveness. Three conditions were established: a writing task with process instruction condition (WT + S; seven classes, 119 students), a writing task-only condition (WT; three classes, 63 students), and a control condition (four classes, 86 students). Teachers in WT and WT + S conditions were instructed to design and implement literacy tasks, with the WT + S condition receiving additional writing process instruction tailored to individual writing approaches. Effects on students’ disciplinary writing performance were assessed using a transfer literacy task about a new topic. After writing, students were asked to indicate their level of epistemic experience during writing. Historical content knowledge gained during the intervention period was measured using a free recall task. Findings showed that writing practice with process instruction (WT + S) significantly enhanced disciplinary writing (effect size = .63) and epistemic experience (effect size = .31). Content knowledge improved across all groups, regardless of condition. This study underscores the potential of targeted writing process instruction as a valuable asset in content classrooms for developing students’ disciplinary writing skills.
When New Fathers Take More Leave, Does Maternal Gatekeeping Decline?
Authors: Donithen Reed , Schoppe-Sullivan Sarah , Berrigan Miranda , Dush Claire Kamp 
Published: February 2025

Abstract
The current study examined associations between the length of paternity leave taken by new fathers and maternal gatekeeping behavior and attitudes (i.e., mothers’ encouragement or discouragement of fathers’ involvement in parenting). Survey data on fathers’ and mothers’ leave length, maternal gatekeeping behavior and attitudes, and psychological and demographic covariates were drawn from a longitudinal study of the transition to parenthood among a sample of 130 dual-earner, different-sex couples in the U.S. Path analysis indicated that longer paternity leave time was associated with lower maternal gateclosing behaviors and attitudes. Paternity leave length was not related to maternal gateopening behavior. Mothers’ leave time was not related to maternal gatekeeping. The use of paternity leave may benefit the coparenting relationship between mothers and fathers by reducing maternal gateclosing behaviors and attitudes, making space for fathers to be more independent and involved parents and for mothers and fathers to adopt more egalitarian parental roles.
Predictors of futile recanalization after intravenous thrombolysis in stroke patients transferred for endovascular treatment
Authors: D’Anna Lucio , Foschi Matteo , Dixon Luke , Bax Francesco , Levee Viva , Fayez Feras , Knight Lucinda , Cella Arianna , Mare’ Alessandro , Kuris Fedra , Pez Sara , Sponza Massimo , Lobotesis Kyriakos , Nguyen Thanh , Sacco Simona , Gigli Gian Luigi , Valente Mariarosaria , Banerjee Soma , Merlino Giovanni ,   the Study Investigators*
Published: February 2025

Abstract
Some patients with large vessel occlusion (LVO) achieve insufficient clinical improvement (futile recanalization, FR) after intravenous thrombolysis (IVT) during inter-hospital transfer for thrombectomy, while others show good outcomes (effective recanalization, ER). This study assessed FR and ER rates among patients treated with IVT at non-thrombectomy primary stroke centers (PSCs) and aimed to identify predictors of FR. We analyzed data from two PSC registries (2016–2022). Inclusion criteria: IVT treatment, anterior circulation LVO, NIHSS ≥ 6, ASPECTS ≥ 5, and documented recanalization at thrombectomy centers. FR was defined as a 90-day poor outcome (mRS 3–6) despite LVO recanalization on initial angiography. Among 190 PSC patients with documented recanalization post-IVT, 113 (59.5%) had FR. Multivariable analysis identified age (OR = 1.03, 95%CI = 1.01–1.07, p = 0.021), NIHSS at the PSC (OR = 1.13, 95%CI = 1.05–1.22, p = 0.026), and collateral status (OR = 0.54, 95%CI = 0.39–0.75, p = 0.001) as independent predictors of FR and 90-day mortality. A model combining age, NIHSS, and collateral score provided the highest predictive accuracy for FR and mortality. FR is common in LVO-related ischemic stroke treated with IVT at non-thrombectomy centers. FR is common in LVO-related ischemic stroke treated with IVT at non-thrombectomy centers. Identifying predictors of FR can guide clinicians in early decision-making, allowing for tailored interventions and informed discussions about expected outcomes, potentially leading to more optimized patient management.

The GOTIC-VTE trial Unique identifier, jRCTs031180124; Registration date, April 06, 2017.

Graphical Abstract
Membrane Fouling and Control Approaches in Membrane Bioreactor Systems: A Review
Authors: Turan Mustafa 
Published: February 2025

Abstract
Membrane bioreactors (MBRs), in which membranes are performed to biological wastewater treatment for biomass separation, ensure many benefits over traditional wastewater treatment. The technology has developed to contain anaerobic MBRs (AnMBRs) due to the profit of generating renewable energy in the form of methane biogas and decreasing the cost of aeration and sludge disposal. Results show that the non-settleable substances and high solid concentrations in AnMBR cause to a significant membrane fouling inclination compared to aerobic MBR. Curiously, there seemed a critical AGS size (1–1.2 mm) for membrane fouling. Above or below critical AGS size, fouling declined as the size increase or decrease. Membrane fouling in MBRs can be reversible (i.e., detachable by physical washing) or irreversible (i.e., detachable by chemical cleaning solely), and can happen on the membrane surface or into the membrane pores. The use of air scouring (for aerobic MBRs) or biogas sparging (for AnMBRs) is widely used for fouling control. This paper provides to review current methods employed to mitigate and control membrane fouling in aerobic MBR, AnMBR and combined MBR systems. Overscale implementation of fouling control approaches should be the focus of future studies.

Graphical Abstract (Liu et al., 2020a)
Asymmetries in Firm-Level Globalization: The Case of Swiss Multinational Enterprises
Authors: Verbeke Alain , Eschmann David , Gugler Philippe 
Published: February 2025

Abstract
This paper addresses the regional and global strategies of multinational enterprises (MNEs), with an application to the largest Swiss companies. We extend Rugman and Verbeke’s (2004) classic approach to measure MNE globalization by adopting a multidimensional lens, whereby we focus on four distinct parameters that evaluate respectively: market success across geographic space (proxied by sales); investments as a response to foreign business opportunities (proxied by assets); human capital (as proxied by the employees’ geographic distribution); and knowledge capital (as measured by patented innovations). We observe substantial discrepancies in globalization levels according to the parameter used. According to this study, the largest segment of companies (42.1%) remains home-regional in terms of sales. Bi-regional firms constitute the second largest category, comprising 28.9% of the sample. Only 21.1% of the companies can be classified as global in terms of sales distribution. Upstream activities such as knowledge capital seem to be more home-region oriented than downstream activities. One critical conclusion of this study is that not a single large Swiss MNE can be considered global in terms of knowledge capital creation.
Mapping sediment depths using seismic arrays, rotational measurements, and spectral ratios
Authors: Finger Claudia , Keil Sabrina , Gotowik Aileen , Jüstel Alexander , Brotzer Andreas 
Published: February 2025

Abstract
Unconsolidated sediments can amplify ground motions, increasing seismic hazard. Horizontal-to-vertical spectral ratios can derive the thickness of sediments overlaying stiffer bedrock. However, additional information about shear velocities and calibration with other structural information is necessary. Here, we propose a strictly ambient seismic noise-based workflow that can map the depth of sediments without additional information from other data sources. Rayleigh wave dispersion curves and ellipticities are derived from three-component beamforming of ambient noise and combined with dispersion curves from six-component measurements and horizontal-to-vertical spectral ratios. This is used to calibrate empirical relations between frequencies of extreme points in spectral ratio curves with depths of sediments. Applying the relations to more than forty seismic station data, we can map the depth of the Tertiary sediments at the southern margin of the lower Rhine embayment, Germany.
Dynamics of pre-release consumer buzz: Driving communication, search, and participation for market performance
Authors: Schreiner Thomas F. , Mandler Timo , van Heerde Harald J. , Haiduk Carolin 
Published: February 2025

Abstract
While pre-release consumer buzz may drive new product market performance, little is known about the importance of its distinct behavioral manifestations: communication, search, and participation. This paper not only studies how these three pre-release buzz behaviors affect market performance but also their dynamic interplay and how firms can drive pre-release buzz. Using movie data, we find self-enhancing and spillover effects of buzz throughout the pre-release period. For driving communication and search behaviors, firm social media posts are most effective, while movie trailers are most effective in evoking participatory behaviors. Furthermore, box office sales benefit the most from pre-release communication, followed by participation and search. These findings extend current knowledge by showing that while all buzz behaviors matter for driving market performance, communication plays a central role due to its powerful spillover effects on search and participation, and firms can effectively stimulate it through social media posts about the new product.
Changes in chemotherapy-induced cognitive impairment in gastrointestinal cancer survivors using multidomain assessments: a prospective cohort study
Authors: Saita Kazuya , Tanabe Kazuaki , Hamai Yoichi , Yamauchi Masami , Kaneko Fumiko , Mikami Yukio , Okamoto Wataru , Okada Morihito , Ohdan Hideki , Okamura Hitoshi 
Published: February 2025

Abstract

Purpose
Risk factors for cancer-related cognitive impairment (CRCI) are diverse; neuroimaging instruments are recommended to complement subjective and objective cognitive assessments. This study aimed to evaluate the feasibility of a multidomain assessment protocol for CRCI in gastrointestinal cancer survivors.

Methods
Twenty-four patients with gastrointestinal cancer were scheduled for chemotherapy, and 24 healthy controls were recruited. The Functional Assessment of Cancer Therapy-cognitive function (FACT-Cog) was used to assess subjective cognitive functions. Objective cognitive function was assessed using the trail making test, auditory verbal learning test (AVLT), and verbal fluency test. Cerebral hemodynamic changes in the prefrontal cortex were measured using portable functional near-infrared spectroscopy (P-NIRS). Assessments were conducted at baseline and 6-month follow-up.

Results
Thirty-eight participants were included in the analysis. There was a statistically significant difference in AVLT-delayed recall (p = 0.002) in the chemotherapy group compared with the healthy control group, but no significant difference in either group for other cognitive assessments. The chemotherapy group exhibited reduced activity in the left frontal pole at 6 months post-treatment compared to baseline (p = 0.018).

Conclusions
Gastrointestinal cancer survivors who receive chemotherapy may exhibit poorer delayed recall of memory functions than healthy individuals. Monitoring prefrontal cortical hemodynamics using P-NIRS during cognitive tasks is feasible for clinical application and understanding CRCI symptoms.

Implications for Cancer Survivors
These multidomain assessments are translatable to clinical practice and useful for other cancers. Additionally, the P-NIRS assessments may offer a deeper understanding on the impact of depressive symptoms and declining motivation on the cognitive function of cancer survivors.