bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ortho‐surgical management of a Conradi–Hünermann syndrome patient: rare case report
Authors: Capelozza Filho Leopoldino , de Almeida Cardoso Mauricio , Caldeira Eduardo José , Capistrano Anderson , da Silva Cordeiro Aldir , Rocha Diógenes 
Published: June 2015

Key Clinical MessageThe Conradi–Hünermann Disease is a rare syndrome, which affects the cranial development and the anatomy of dental occlusion. After interdisciplinary treatment completion, the patient reached satisfactory facial anatomy, as well as regular occlusal relationship, attested 2 years of accompaniment.
Suzuki–Miyaura Diversification of Amino Acids and Dipeptides in Aqueous Media
Authors: Willemse Tom , Van Imp Karolien , Goss Rebecca J. M. , Van Vlijmen Herman W. T. , Schepens Wim , Maes Bert U. W. , Ballet Steven 
Published: June 2015

AbstractThe Suzuki–Miyaura derivatisation of free amino acids, peptides and proteins is an attractive area with considerable potential utility for medicinal chemistry and chemical biology. Here we report the modification of unprotected and Boc‐protected aromatic amino acids and dipeptides in aqueous media, enabling heteroarylation and vinylation. We systematically investigate the impact of the peptide backbone and adjacent amino acid residues upon the reaction. Our studies reveal that although asparagine and histidine hinder the reaction, by utilising dppf, a ferrocene‐based bidentate phosphine ligand, cross coupling of halophenylalanine or halotryptophan adjacent to such a residue could be enabled. Our studies reveal dppf to have good compatibility with all unprotected, proteinogenic amino acid side chains.
MgI2‐Mediated Chemoselective Cleavage of Protecting Groups: An Alternative to Conventional Deprotection Methodologies
Authors: Berthet Mathéo , Davanier Florian , Dujardin Gilles , Martinez Jean , Parrot Isabelle 
Published: June 2015

AbstractThe scope of MgI2 as a valuable tool for quantitative and mild chemoselective cleavage of protecting groups is described here. This novel synthetic approach expands the use of protecting groups, widens the concept of orthogonality in synthetic processes, and offers a facile opportunity to release compounds from solid supports.
White Electroluminescence with Simultaneous Three‐Color Emission from a Four‐Armed Star‐Shaped Single‐Polymer System
Authors: Jiu Yuanda , Wang Jianyun , Liu Chengfang , Lai Wenyong , Zhao Lingling , Li Xiangchun , Jiang Yi , Xu Weidong , Zhang Xinwen , Huang Wei 
Published: June 2015

AbstractA four‐armed star‐shaped single‐polymer system with 4,7‐bis(5‐(4‐(9H‐carbazol‐9‐yl)phenyl)‐4‐hexylthiophen‐2‐yl)benzo[c][1,2,5]thiadiazole (FTBT) as a red emissive core, polyfluorene (PF) as blue emissive arms and 1,3‐benzo thiadiazole (BT) as green emissive dopants was designed and synthesized, in which red, green, and blue (RGB) emission balance can be achieved by adjusting the doping concentration of FTBT and BT discreetly. A typical single‐emissive‐layer device (ITO/PEDOT:PSS/polymer/TPBI/LiF/Al) was studied and discussed, realizing a pure and stable white emission with a luminous efficiency (LE) of 1.59 cd·A−1 and CIE coordinates of (0.31, 0.34). The high‐color‐quality white electroluminescence of the devices could be mainly attributed to the suppressed intermolecular interactions, and partial energy transfer from the blue PF arms to the red and green dopants.
Use of FTA cards for the storage of breast carcinoma nucleic acid on fine‐needle aspiration samples
Authors: Peluso Anna Lucia , Cascone Anna Maria , Lucchese Lucrezia , Cozzolino Immacolata , Ieni Antonio , Mignogna Chiara , Pepe Stefano , Zeppa Pio 
Published: June 2015

BACKGROUNDThe preservation and storage of nucleic acids is important for DNA molecular techniques. The material obtained by fine‐needle aspiration (FNA) is often scanty and can not be wasted. FTA cards are filter papers that immobilize and stabilize nucleic acids and can be stored at room temperature. The current study evaluated whether nucleic acids of breast carcinoma cells, obtained by FNA in a clinical setting, may be collected, stored, and preserved on FTA cards.METHODSThirty breast carcinoma, 5 non‐Hodgkin lymphoma (NHL), and 5 benign reactive lymph node (RLN) cell samples obtained by FNA were stored at −80°C and on FTA cards. DNA extraction and polymerase chain reaction were performed on cells at −80°C and on 2 punched disks of FTA cards. Fifty nanograms of extracted DNA from both sample types were used to amplify the Janus Kinase 2 (JAK2) gene.RESULTSThe mean value of DNA extracted from breast carcinoma cells was 28.19 ng/µL for that stored at −80°C and 3.28 ng/µL for that stored on FTA cards. Agarose gel analysis demonstrated expected bands of DNA in 29 cases (97%) with both methods. The mean value of DNA extracted from NHL and RLN samples was 37.54 ng/µL and 4.28 ng/µL, respectively, and agarose gel analysis demonstrated bands of high molecular weight DNA in both methods. Significant differences in DNA yield were found between storage at −80°C and FTA cards (P<.0001), but no differences were detected between 260/280 nm ratios in breast carcinoma and NHL/RLN samples.CONCLUSIONSFTA cards can be conveniently used for the storage of breast carcinoma cells obtained by FNA, thus providing a reliable alternative to traditional methods. Cancer (Cancer Cytopathol) 2015;123:582–92. © 2015 American Cancer Society.
Color constancy from invariant wavelength ratios: An algorithm to simplify the chromatic adaptation model
Authors: Pridmore Ralph W. 
Published: June 2015

AbstractIn a recent article on color constancy, the chromatic adaptation model was of a novel type comprising three components separately calculated—hue, chromaticness, and lightness. The constant hue component was a simple calculation of predicted wavelength but the other two components were less direct. This article provides an algorithm to simplify the model's calculation. Calculation is far simpler and more intuitive than conventional models using complex 3 × 3 matrix transforms with their various and contentious adaptation primaries and potential disadvantages (e.g., in brightness and color gamut). The model is shown to be at least as accurate as six other (conventional) models and does not require high math skill. © 2015 Wiley Periodicals, Inc. Col Res Appl, 41, 468–476, 2016
Dye‐Sensitized Solar Cells with Biferrocenyl Antennae Having Quinoxaline Spacers
Authors: Chauhan Ratna , Shahid Mohammad , Trivedi Manoj , Amalnerkar Dinesh P. , Kumar Abhinav 
Published: June 2015

AbstractFour biferrocene‐based dyes with quinoxaline spacers possessing functional groups [H (2), Cl (3), NO2 (4) and COOH (5)] were successfully synthesized and characterized by elemental analyses, IR spectroscopy, electronic absorption, 1H NMR and 13C NMR spectroscopy, and mass spectrometry. The synthesized dyes as well as the starting diketenone (1), from which quinoxalines 2–5 were synthesized, were exploited as photosensitizers in TiO2‐based dye‐sensitized solar cells. The spectral responses of dyes 2–5 were extended into the visible region up to λ = 550 nm. Amongst all the ferrocenyl dyes with a quinoxaline spacer, dyes having Cl (3), NO2 (4), and COOH (5) substituents showed photovoltaic performance that was superior to that of starting material 1 and that of quinoxaline derivative 2. The superior performances of 3, 4, and 5 are probably because of the abilities of these systems to accept high loadings of the dye on the TiO2 surface and the long lifetime of electrons in the TiO2 conduction band. Dye 5 showed better thermal stability than the state‐of‐art dye N719 and has a comparable lifetime of electrons in the conduction band.
No associations between objectively measured physical activity and spinal pain in 11–15‐year‐old Danes
Authors: Aartun E. , Hartvigsen J. , Boyle E. , Hestbaek L. 
Published: June 2015

AbstractBackgroundPhysical activity is thought to play a role in spinal pain (neck pain, mid back pain, low back pain) in children and adolescents, either as a risk or protective factor, but current evidence is conflicting. The overall aim of this study was to determine the cross‐sectional and longitudinal associations between different levels of objectively measured physical activity, i.e. sedentary; moderate and vigorous; vigorous physical activity, and spinal pain in 11–15‐year‐old Danes.MethodsData were collected at baseline (2010) (n = 906) and at follow‐up 2 years later (n = 625) in a school‐based prospective cohort study. Physical activity was measured using the Actigraph GT3X Triaxial Activity Monitor, which measures the intensity of physical activity over time. This was worn for 1 week and spinal pain was assessed via e‐survey that participants completed during school time. Potential confounders included in the multivariable analyses were sex, anthropometry, physical fitness, social status and psychosocial factors. In the longitudinal study, analyses stratified by baseline pain status were performed.ResultsThere were neither cross‐sectional nor longitudinal associations between different levels of objectively measured physical activity and spinal pain over the 2‐year period.ConclusionObjectively measured physical activity was not associated with spinal pain. However, it remains to be seen whether there is an association over a longer follow‐up period. Future research should focus on the more qualitative aspects of physical activity, such as different sports activities.
Inkjet‐Printed TiO2 Nanoparticles from Aqueous Solutions for Dye‐Sensitized Solar Cells (DSSCs)
Authors: Cherrington Ruth , Hughes Darren J. , Senthilarasu S. , Goodship Vannessa 
Published: June 2015

AbstractThis work reports on the formulation of suitable ink for inkjet printing of TiO2 by investigating the critical parameters of particle size, pH, viscosity, and stability. Aqueous suspensions of TiO2 nanoparticles (Degussa, P25) were prepared with the addition of 25 wt % polyethylene glycol 400 as a humectant to minimize drying at the printer nozzles and reduce the likelihood of nozzle blockage. The inkjet‐printed TiO2 layers were assembled into dye‐sensitized solar cells. The current–voltage (I–V) characteristics were measured under one sun (air mass 1.5, 100 mW cm−2) using a source meter (Model 2400, Keithley Instrument, Inc.), and the active area of the cell was 0.25 cm2. The inkjet‐printed TiO2 photoanode produced a device with a short‐circuit current (Isc) of 9.42 mA cm−2, an open‐circuit voltage (Voc) of 0.76 V, and a fill factor (FF) of 0.49, resulting in a power conversion efficiency (PCE) of 3.50 %.
The Spanish Validation of the Accommodation and Enabling Scale for Eating Disorders Among Carers: A Pilot Study
Authors: Quiles Marcos Yolanda , Quiles Sebastián María José , Pamies Aubalat Lidia , Sepúlveda García Ana Rosa , Treasure Janet 
Published: June 2015

AbstractLiterature suggests that families may accommodate patients' symptoms in attempts to alleviate family conflict and stress. These accommodating and enabling behaviours may have a negative impact on carers and those they care for. There are no self‐report questionnaires validated in Spanish to measure accommodation among relatives of patients with an eating disorder. The aim of this study was to examine the psychometric properties of the Spanish version of the Accommodation and Enabling Scale for Eating Disorders (AESED‐S) among relatives of eating disorder patients. A cross‐sectional study of 90 relatives was carried out to explore the factor structure, reliability and validity of the AESED‐S. The internal consistency of the Spanish version of the AESED subscales was good, ranging from .89 to .81. The correlation of the five subscales with conceptually related measures (negative caregiving experience and distress) supports the convergent validity of this instrument in this sample. Results indicated that the Spanish version of the AESED provides a reliable and valid tool for assessing family accommodation in the context of having a relative with an eating disorder. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association.
Flame Spray Synthesis of BaZr0.8Y0.2O3–δ Electrolyte Nanopowders for Intermediate Temperature Proton Conducting Fuel Cells
Authors: Bozza F. , Arroyo Y. , Graule T. 
Published: June 2015

AbstractFlame Spray Synthesis (FSS) technique has been used for the preparation of BaZr0.8Y0.2O3–δ (BZY20) nanoprecursors. The nanoprecursors were composed of a perovskite phase mixed with doped Zirconia and barium nitrate. Pure phase powder could be obtained after calcining the precursors at 1,200 °C. Both nanoprecursors and pure phase powder were then sintered at 1,600 °C to obtain dense specimen. AC impedance spectroscopy performed on the sintered samples allowed correlation of the electrical properties of the samples to their microstructures. The sintered nanoprecursors compared with the sintered pure phase powders showed enhanced grain growth associated with higher grain boundary conductivity. The influence of the reactive sintering on the enhanced grain growth and electrical properties in the nanoprecursors is discussed. The high total proton conductivity measured (7.7·10−3 S cm−1 at 450 °C) promotes FSS as an effective powder synthesis method for the preparation of BZY20 electrolyte material for proton conducting fuel cells operating in the intermediate temperature range.
Factors associated with self‐rated sexual function in Korean patients with schizophrenia receiving risperidone monotherapy
Authors: Lee Ju‐Yeon , Kim Sung‐Wan , Lee Yo‐Han , Kang Hee‐Ju , Kim Seon‐Young , Bae Kyung‐Yeol , Kim Jae‐Min , Shin Il‐Seon , Yoon Jin‐Sang 
Published: June 2015

ObjectiveThis study aims to investigate the factors associated with sexual function in Korean patients with schizophrenia.MethodsThis study evaluated 169 patients with schizophrenia who were receiving risperidone monotherapy. The Visual Analog Scale was used to assess sexual function in terms of sexual desire, sexual arousal, and sexual satisfaction. The Positive and Negative Syndrome Scale, the Beck Depression Inventory, the Korean version of the Subjective Well‐being under Neuroleptic Treatment—Brief Form (SWN‐K) scale, and the Drug Attitude Inventory (DAI) were also administered.ResultsSexual function was negatively associated with age, duration of illness, gender (female), marital status (single), the presence of tardive dyskinesia, and Beck Depression Inventory score, but positively associated with the SWN‐K and DAI scores. A linear regression analysis revealed that being male and married had significant positive associations with sexual arousal, sexual satisfaction, and/or sexual desire, while the presence of tardive dyskinesia and a longer duration of illness were associated with poor sexual arousal and/or sexual desire. Additionally, sexual function was significantly associated with the SWN‐K and DAI scores in multivariate analysis.ConclusionsThe acknowledgement and management of sexual dysfunction in patients with schizophrenia by clinicians may be important for improvement of their quality of life and adherence to medication. Copyright © 2015 John Wiley & Sons, Ltd.
Polycaprolactone fiber meshes provide a 3D environment suitable for cultivation and differentiation of melanocytes from the outer root sheath of hair follicle
Authors: Savkovic Vuk , Flämig Franziska , Schneider Marie , Sülflow Katharina , Loth Tina , Lohrenz Andrea , Hacker Michael Christian , Schulz‐Siegmund Michaela , Simon Jan‐Christoph 
Published: June 2015

AbstractMelanocytes differentiated from the stem cells of human hair follicle outer root sheath (ORS) have the potential for developing non‐invasive treatments for skin disorders out of a minimal sample: of hair root. With a robust procedure for melanocyte cultivation from the ORS of human hair follicle at hand, this study focused on the identification of a suitable biocompatible, biodegradable carrier as the next step toward their clinical implementation. Polycaprolactone (PCL) is a known biocompatible material used for a number of medical devices. In this study, we have populated electrospun PCL fiber meshes with normal human epidermal melanocytes (NHEM) as well as with hair‐follicle‐derived human melanocytes from the outer root sheath (HUMORS) and tested their functionality in vitro. PCL fiber meshes evidently provided a niche for melanocytes and supported their melanotic properties. The cells were tested for gene expression of PAX3, PMEL, TYR and MITF, as well as for proliferation, expression of melanocyte marker proteins tyrosinase and glycoprotein 100 (gp100), L‐DOPA‐tautomerase enzymatic activity and melanin content. Reduced mitochondrial activity and PAX‐3 gene expression indicated that the three‐dimensional PCL scaffold supported differentiation rather than proliferation of melanocytes. The monitored melanotic features of both the NHEM and HUMORS cultivated on PCL scaffolds significantly exceeded those of two‐dimensional adherent cultures. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 26–36, 2016.
Long‐term outcomes and safety of laparoscopic liver resection surgery for hepatocellular carcinoma and metastatic colorectal cancer
Authors: Geller David A. , Tsung Allan 
Published: June 2015

HighlightTwo recent multi‐institutional Japanese studies used propensity score matching to compare the perioperative and long‐term outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma or colorectal liver metastases. They found no difference in oncologic outcomes between the two groups, while the laparoscopic liver resection group had less blood loss and shorter hospital stay.
Unilateral versus bilateral percutaneous kyphoplasty for osteoporotic vertebral compression fractures: A systematic review and meta‐analysis of RCTs
Authors: Feng Hui , Huang Peng , Zhang Xuesong , Zheng Guoquan , Wang Yan 
Published: June 2015

ABSTRACTThe purpose of this research was to compare the efficacy and safety of unilateral versus bilateral PKP for osteoporotic vertebral compression fractures (OVCFs). Six databases (Cochrane, PubMed, MEDLINE, EMBASE, SinoMed, and CNKI) were searched without language restrictions. Twelve randomized controlled trials involving a total of 1,030 patients were identified. The results indicate that unilateral PKP had a better degree of pain relief (visual analog scale) than bilateral PKP (p = 0.04; 95%CI = −0.36 to −0.00) with short‐term follow‐up (within 4 weeks) after operation. The radiological outcome assessment with short‐term follow‐up after operation indicates bilateral PKP had a better degree of anterior vertebral height restoration (p = 0.03; 95%CI = −2.58 to −0.14). Operation time and cement dosage were less for unilateral PKP (p < 0.05). There were no differences in complications such as cement leakage and adjacent vertebral fractures between two approaches (p = 0.06 and p = 0.97, respectively). Life quality assessment (SF‐36) indicates unilateral PKP had a better result of bodily pain relief (p < 0.05; 95%CI = 3.93 to 7.48) and general health benefit (p < 0.05; 95%CI = 0.02 to 2.93) with short‐term follow‐up after operation. We suggest that a unilateral PKP is advantageous. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1713–1723, 2015.
Response to tumor necrosis factor‐α mediated inflammation involving activation of prostaglandin E2 and Wnt signaling in nucleus pulposus cells
Authors: Hiyama Akihiko , Yokoyama Katsuya , Nukaga Tadashi , Sakai Daisuke , Mochida Joji 
Published: June 2015

ABSTRACTThe cyclooxygenase 2 (COX‐2) product, prostaglandin E2 (PGE2), acts through a family of G protein‐coupled receptors designated E‐prostanoid (EP) receptors that mediate intracellular signaling by multiple pathways. However, it is not known whether crosstalk between tumor necrosis factor‐α(TNF‐α)–PGE2‐mediated signaling and Wnt signaling plays a role in the regulation of intervertebral disc (IVD) cells. In this study, we investigated the relationship between TNF‐α–PGE2 signaling and Wnt signaling in IVD cells. TNF‐α increased the expression of COX‐2 in IVD cells. The EP receptors EP1, EP3, and EP4 were expressed in IVD cells, and TNF‐α significantly increased PGE2 production. Stimulation with TNF‐α also upregulated EP3 and EP4 mRNA and protein expression in IVD cells. The inductive effect of the EP3 and EP4 receptors on Topflash promoter activity was confirmed through gain‐ and loss‐of‐function studies using selective EP agonists and antagonists. PGE2 treatment activated Wnt–β‐catenin signaling through activation of EP3. We conclude that TNF‐α‐induced COX‐2 and PGE2 stimulate Wnt signaling and activate Wnt target genes. Suppression of the EP3 receptor via TNF‐α–PGE2 signaling seems to suppress IVD degeneration by controlling the activation of Wnt signaling. These findings may help identify the underlying mechanism and role of Wnt signaling in IVD degeneration. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1756–1768, 2015.
Relationship between synovial fluid ARGS‐aggrecan fragments, cytokines, MMPs, and TIMPs following acute ACL injury: A cross‐sectional study
Authors: Tourville Timothy W. , Poynter Matthew E. , DeSarno Michael J. , Struglics André , Beynnon Bruce D. 
Published: June 2015

ABSTRACTSevere knee trauma, such as an ACL disruption, produces aggrecan degradation as evidenced by elevated synovial fluid (SF) N‐terminal (393) Alanine–Arginine–Glycine–Serine (ARGS) neoepitope (or ARGS‐aggrecan) and is associated with inflammatory activity soon after injury. However, it is not known if this process persists for a substantial time interval following the initial trauma. The purpose of this study was to evaluate relationships between SF ARGS concentrations and an array of cytokines, matrix metalloproteases (MMPs), and tissue inhibitor of metalloproteases (TIMPs) during the initial 6 months following ACL rupture. SF samples from 67 ACL‐injured subjects (29 women) were analyzed within 6 months of injury (18–155 days), immediately prior to surgical ACL reconstruction. Relationships between ARGS and individual analyte concentrations, as well as MMP/TIMP ratios were evaluated. Statistically significant relationships were found between ARGS and basic fibroblast growth factor (FGF2) (p = 0.03) and TIMP‐3 (p = 0.01). Our findings suggest that FGF2, considered to be primarily catabolic in articular cartilage, is not downregulated as ARGS concentration declines over time since injury. In addition, these results support the hypothesis that an upregulation of TIMP‐3, the primary aggrecanase inhibitor, is elicited in response to increased aggrecan degradation, which may inhibit further cleavage. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:1796–1803, 2015.