bluuebunny/crossref_metadata_2025_split huggingface dataset:
AGING AND CLONAL HEMATOPOESIS
Authors: Богданов А.Н. , Волошин С.В. , Куневич Е.О. , Михалева М.А. 
Published: August 2024

С возрастом во всех тканях увеличивается количество соматических мутаций. Лучше всего этот процесс изучен в стволовых кроветворных клетках. Некоторые мутации могут привести к пролиферативному преимуществу и экспансии стволовых кроветворных клеток с образованием клона. Клональное кроветворение широко распространено у пожилых людей. Клональный гемопоэз неопределенного потенциала (КГНП) — феномен, который чаще встречается в пожилом возрасте и характеризуется соматическими мутациями в клетках-предшественницах гемопоэза с формированием нескольких минорных клонов, экспансия которых способна постепенно вытеснить нормальный гемопоэз. Развитие КГНП является независимым фактором риска опухолей системы крови, сердечно-сосудистых заболеваний и общей летальности. При КГНП чаще всего мутируют гены DNMT3A и TET2, которые участвуют в метилировании ДНК. На основании возрастного изменения метилирования разработаны эпигенетические часы организма человека, позволяющие выявить эпигенетическое старение. Сочетание последнего и КГНП связано с неблагоприятными исходами для здоровья. Дальнейшие исследования позволят понять значение клонального гемопоэза и КГНП в процессе старения и развитии различных заболеваний, определить возможности целенаправленного воздействия на мутировавшие клоны.
The number of somatic mutations among all tissues increases along with age. This process was well-studied in hematopoietic stem cells (HSCs). Some mutations lead to a proliferative advantage and expansion of HSCs to form a dominant clone. Clonal hematopoiesis is general in the elderly population. Clonal hematopoiesis of indeterminate potential (CHIP) is a more common phenomenon in the elderly and is defined as somatic mutations in clonal blood cells without any other hematological malignancies. The development of CHIP is an independent risk factor for hematological malignancies, cardiovascular diseases, and reduced overall survival. CHIP is frequently associated with mutations in DNMT3A and TET2 genes involved in DNA methylation. The epigenetic human body clocks have been developed based on the age-related changes in methylation, making it possible to detect epigenetic aging. The combination of epigenetic aging and CHUP is associated with adverse health outcomes. Further research will reveal the significance of clonal hematopoiesis and CHIP in aging, acquiring various diseases, and determining the feasibility of influencing the mutagenic potential of clones.
RELATIONSHIP BETWEEN COGNITIVE STATUS AND OTHER GERIATRIC SYNDROMES IN PATIENTS AGED 65 YEARS AND OLDER WITH CHRONIC HEART FAILURE
Authors: Изюмов А.Д. , Ерусланова К.А. , Мхитарян Э.А. , Федин М.А. , Котовская Ю.В. , Ткачёва О.Н. 
Published: August 2024

В данной статье представлена частота встречаемости гериатрических синдромов у пациентов 65 лет и старше с ХСН в зависимости от когнитивного статуса. На базе Российского геронтологического научно-клинического центра были отобраны 149 человек с подтвержденной ХСН согласно Европейским критериям 2021 г. В данной выборке 50,3 % пациентов имели умеренные когнитивные нарушения, 17,5 % — выраженные. С возрастом частота встречаемости и тяжесть когнитивных нарушений возрастала. Среди пациентов с когнитивными нарушениями было больше лиц со сниженной базовой и инструментальной активностью, с высоким риском развития мальнутриции и непосредственно мальнутрицией, синдромом старческой астении, а также с сенсорным дефицитом по слуху. Также по мере ухудшения когнитивных функций снижалась медиана индексов Бартел, Лоутона, краткой шкалы питания, краткой батареи тестов физического функционирования, шкалы социальной изоляции Люббена и нарастала медиана шкалы Морзе, гериатрической шкалы депрессии. Наличие сенсорного дефицита по слуху ассоциировалось с увеличением шансов выявления когнитивных нарушений в 3,6 раза, а наличие синдрома старческой астении, базовой зависимости в повседневной жизни или риска недостаточности питания — в 2,4 раза.
This article presents the incidence of geriatric syndromes in patients with chronic heart failure 65 years of age and older, depending on cognitive status. At the Russian gerontological center, 149 people with confirmed chronic heart failure were selected according to the European criteria of 2021. In this sample, 50,3 % of patients had mild cognitive impairment, and 17,5 % had severe cognitive impairment. With age, the incidence and severity of cognitive impairment increased. Among patients with cognitive impairment, there were more patients with reduced basic and instrumental activities of daily living, with a high risk of malnutrition and malnutrition, frailty and patients with hearing loss. Also, as cognitive functions declined, the median score of the Barthel and Lawton index, the mini nutritional assessment, the short physical performance battery, the Lubben social network scale decreased, and the median of the Morse fall risk scale and the geriatric depression scale increased. The presence of hearing loss was associated with a 3,6-fold increase in the odds of being diagnosed with cognitive impairment, and the presence of frailty syndrome, basic dependence in daily life, or the risk of malnutrition by a 2,4-fold increase.
The Relationship Between The Hemodialysis Span and The Stress Level and Sleep Quality of Chronic Kidney Failure Patients In Hemodialysis Room At Tk. III Slamet Riyadi Hospital Surakarta
Authors: Rahmad Muhamad Nur , Sutarman Sutarman , Kanita Maria Wisnu , Utami Yola Kinanthi Wening 
Published: August 2024

Hemodialysis will affect stress levels and sleep quality in chronic kidney failure patients. The longer a patient with chronic kidney failure undergoes hemodialysis therapy, the patient's stress level and sleep quality will worsen. The study aimed to analyze the relationship between the term hemodialysis and the stress level and sleep quality of chronic kidney failure patients at Tk.III Slamet Riyadi Hospital, Surakarta. The research adopted a quantitative descriptive analytical design with a cross-sectional approach. The sampling technique used total sampling with 57 respondents. Data collection methods utilized the Depression Anxiety Stress Scale (DASS-42) and Pittsburgh Sleep Quality Index (PSQI) questionnaires. The statistical test operated the gamma test. The results revealed the relationship between the term hemodialysis and stress levels and sleep quality with a p-value of 0.009 and 0.006. It inferred a relationship between the hemodialysis span, stress levels, and sleep quality. The correlation value between variables is 0.431 and 0.410. The longer the hemodialysis, the higher the stress level and the worse the patient's sleep quality (one blank single space line, 9 point font)
LITERASI PEMASARAN ONLINE PADA ANGGOTA KELOMPOK USAHA BERSAMA GRAHA PERMAI DI KELURAHAN TUAH KARYA KECAMATAN TUAH MADANI
Authors: Hadiyati Hadiyati , Fatkhurahman Fatkhurahman , N Arizal 
Published: August 2024

Kurangnya pengetahuan dan pemahaman anggota KUB Graha Permai dalam memasarkan produk secara online yakni dengan memanfaatkan media sosial menyebabkan kalah saing penjualan yang dilakukan selama ini, hal ini karena kurangnya kemampuan memahami dan menggunakan media online dalam memasarkan produk. Tujuan diadakan pengabdian bagi masyarakat ini dimaksudkan agar anggota KUB Graha Permai mendapatkan pengetahuan dan pemahaman dan ketrampilan dalam meningkatkan penjualan melalui pemasaran online dengan memanfaatkan media sosial. Target yang dicapai dalam pengabdian ini adalah kemampuan menggunakan media sosial dalam memasarkan produk. Metode yang digunakan adalah memberikan pelatihan pemilihan tempat usaha dalam meningkatkan pemasaran produk yang dihasilkan anggota KUB Graha Permai. Metode ceramah dan kunjungan ke tempat jasa transportasi yakni grab, evaluasi menggunakan pre test dan pos test akan memberikan penilaian yang lebih nyata kepada mitra akan keberhasilan kegiatan ini. Diharapkan mitra akan mengikuti penjelasan dengan sungguh-sungguh dan ditargetkan menghasilkan pengetahuan dan ketrampilan dalam memilih tempat usaha yang baik.Hasil pengabdian menunjukkan adanya perubahan pengetahuan dan pemahaman mengenai literasi pemasaran online produk olahan makanan anggota KUBE Graha Permai.
Ta5+-substitution effects on crystal structure and ferroelectric property in HfO2-based films
Authors: Maekawa Yoshiki , Mimura Takanori , Inaguma Yoshiyuki , Uchida Hiroshi , Hu Yuxian , Okamoto Kazuki , Funakubo Hiroshi 
Published: August 2024

Abstract
To investigate the Ta5+-substitution effects on crystal structure and ferroelectric property in HfO2-based films, Ta
x
Hf1−x
O2+δ
films with various film thicknesses and Ta content were prepared. The ferroelectric orthorhombic phase was formed in a wide film thickness range of 20–100 nm while in a narrow composition range of x = 0.10–0.14. These thickness-insensitive and composition-sensitive characteristics of Ta5+-substituted HfO2 film are similar to Y3+ rather than Zr4+. The X-ray photoelectron spectroscopy measurement suggests that the ionic state of Ta is not reduced and Ta
x
Hf1−x
O2+δ
film has an excess oxygen state. The excess oxygen may consist of a combination of oxygen vacancies and more interstitial oxygens. These defects facilitate the formation of the ferroelectric phasebut also decrease the breakdown voltage and increase the leakage current in Ta5+-substituted HfO2 films. On the other hand, the generation of excess oxygen indicates the possibility of controlling oxygen vacancies which deteriorate fatigue and retention properties.
PENINGKATAN PEREKONOMIAN PETANI MELALUI MARKETING DIGITAL
Authors: Feriady Anton , Saputera Surya Ade , Selviani Ayudho 
Published: August 2024

ABSTRACT
Muara Pulutan Village is a village that has great potential in the agricultural sector. However, farmers in this village still experience difficulties in marketing their products, resulting in low income. For this reason, community service activities are carried out with the aim of increasing farmers' income through digital marketing. This activity is carried out by providing training to farmers on how to use social media and marketplaces to market their products. Apart from that, farmers are also assisted in creating attractive product photos and videos and writing informative product descriptions. The results of this activity show that farmers in Muara Pulutan Village have been able to use social media and marketplaces to market their products. This results in an increase in their income.
Keywords: Muara Pulutan Village, farmers, digital marketing, social media, marketplace, income
PELATIHAN DASAR DETEKSI DINI PERTUMBUHAN DAN PERKEMBANGAN ANAK BAGI GURU RA AL-IKHWAN BANGKALAN
Authors: Qomari Selvia Nurul , Maduratna Enggal Sari , Firdaus Nailufar 
Published: August 2024

The growth and development of children has increased rapidly at an early age, from 0 to 5 years. This period is often referred to as the "Golden Age" phase. The golden age is a very important period to pay close attention to the growth and development of children so that they can be detected as early as possible if an abnormality occurs. As early as possible, monitoring of growth and development can be carried out by parents themselves at home and teachers at school, especially at the RA/PAUD level. Therefore, RA/PAUD teachers need to be equipped with basic knowledge and skills regarding early detection of child growth and development.
Community service activities carried out are in the form of introducing instruments, procedures for using instruments, and how to interpret the results of the examination for early detection of growth and deviations. The instruments introduced include the WHO Z-score curve to assess growth, as well as the Developmental Pre-screening Questionnaire (KPSP). As many as 10 teachers were taught how to measure a child's growth, and conduct developmental screening with KPSP
The results of the activity showed that the teacher of RA Al-Ikhwan enthusiastically welcomed the training on early detection of growth and development. Most of the teachers were able to carry out examinations and interpret the results well. However, the method of conducting interviews and the use of screening tools still needs to be improved.
PENTINGNYA ASI UNTUK IBU BEKERJA YANG MENYUSUI DI MLAJAH BANGKALAN
Authors: Aini Qurrotu 
Published: August 2024

The cause of the emergence of nutritional problems in children under five is influenced by many interrelated factors. It is directly influenced by several things, namely the child does not get enough nutritious food at the age of five, the child does not get adequate nutritional care and the child suffers from an infectious disease. One of the causes of malnutrition is that babies do not receive full breast milk until the first 6 months of age. The method used to carry out community service is by collecting data on the number of breastfeeding mothers in Mlajah Bangkalan. The targets of this program are all breastfeeding mothers in Mlajah Bangkalan and one of their closest people (husband or parent). Health workers will be assisted or accompanied by cadres to run the ASI class program. As is well known, the role of the closest family is very important in providing motivation to breastfeeding mothers. Not only families, midwife assistants, namely cadres are also involved in providing education.
During the process of the ASI Class activities program, which consists of a cadre formation program, counseling, giving lactation medians, and the entire program runs smoothly. All preparations have been made by the team, the village youth organization and the village midwives involved. The drawbacks that may occur in the implementation of the ASI Class program are the activities of the ASI Class program in conjunction with the daily activities of mothers so that there are several programs that must be rescheduled.
EARLY DETECTION AND TREATMENT OF HYPERTENSION WITH COCONUT WATER
Authors: Masroni Masroni 
Published: August 2024

The BATARA village (Read Taman Rimba) is located on the edge of the forest in the Papring area. This village is about 15 kilometres from downtown Banyuwangi, and is located at an altitude of 1000 meters above sea level. The location and infrastructure that are still inadequate will have an impact on education and health services because of the distance from health facilities, so that it is possible that it will be fatal if there is a complication of hypertension such as stroke or other diseases if not handled immediately. To train the community's independence in health problems, by providing Health Education regarding early detection of hypertension and treatment with coconut water and how to carry out blood pressure measurements to prevent heart, kidney, brain and other diseases. The implementation of this service includes 3 stages, the first stage; socialization of activities to be carried out, identification of needs, identification of existing potentials and weaknesses and organizing activities, second stage; the implementation stage of activities in order to improve competence in a peer group and comprehensive manner, while the third stage, monitoring and evaluation in order to achieve the success of the activity. The results of this Community Service Activity, the residents of BATARA village are able to prevent hypertension with coconut water and are able to carry out blood pressure measurements independently in order to prevent hypertension and its complications.

Keywords: Detection, early treatment, hypertension, coconut water,
PENDIDIKAN KESEHATAN TENTANG PENTINGNYA GIZI IBU HAMIL DIMASA PANDEMI COVID-19 DI DESA PADEMAWU BARAT
Authors: Eliyana Yayuk , Yunita Emi , Wulandari Herlina 
Published: August 2024

Masa pandemi COVID-19 merupakan wabah virus terbesar yang terjadi di dunia. Dampak dari pandemi ini kemungkinan besar juga berdampak pada kekurangan gizi pada ibu hamil. Peningkatan pemenuhan gizi ibu hamil sangat penting untuk pertumbuhan dan perkembangan janin Ibu harus memiliki status gizi yang baik dan mengkonsumsi makanan yang bervariasi terutama di masa pandemi COVID-19 ini. Perpaduan nutrisi seimbang juga penting untuk dapat meningkatkan system kekebalan tubuh dan menurunkan resiko penyakit kronis dan penyakit menular. Tujuan kegiatan pengabdian kepada masyarakat ini yaitu untuk memberi edukasi pada ibu hamil akan pentingnya gizi pada ibu hamil selama pandemic COVID-19. Adapun metode yang digunakan yaitu dengan cara penyuluhan. Mitra kerjasama yaitu dengan bidan Puskesmas Pademawu Kabupatrn Pamekasan. Hasil yang diperoleh yaitu sebagian besar ibu faham akan pentingnya kebutuhan gizi ibu hamil selama pandemi covid 19 untuk meningkatkan sistem kekebalan tubuh ibu hamil.
YOGA IS A SOLUTION FOR WEIGHT LOSS AND STRESS IN INSULIN RESISTANCE POLYCYSTIC OVARY SYNDROME (PCOS)
Authors: Zainiyah Zakkiyatus , Susanti Eny , Suhron M 
Published: August 2024

Polycystic Ovary Syndrome (PCOS) is an endocrine disorder that often occurs in women of reproductive age, which is characterized by menstrual disorders (amenorrhea/oligomenorrhea), hirsutism, acne, alopecia and increased androgen hormones (testosterone). Based on the 1990 National Institutes of Health diagnostic criteria, the prevalence of PCOS is 6 to 10% and the Rotterdam 2003 criteria for PCOS prevalence is around 4–6% of women of reproductive age. Based on research by Santoso and Irawan, 2007 the prevalence of PCOS in Surabaya in women of reproductive age is 4.5%. The method of community service is by collecting data on PCOS patients who have been examined by dr. obgyn with a diagnosis of PCOS at the local midwife at PMB Sri Andini, SST, Bd in Sepulu, Bangkalan, after that collecting all PCOS patients on a predetermined day and explaining the purpose from community service and counseling on simple ways to lose weight in PCOS patients, followed by weighing, measuring height and abdominal circumference or Waist Circumference and Waist to Hip Ratio (w/h), and conducting interviews by giving questionnaires, giving an explanation of the importance of weight loss for health with Yoga exercise which aims to improve blood circulation and improve health. Based on the results of Yoga management given 4 times a month, it was obtained from 10 patients 2 people who experienced weight loss and 8 people with fixed weight, and from stress, patients from moderate and severe stress experienced a decrease in mild or normal stress. Yoga is still given or practiced at home. Every 2 times a week.
PENGGUNAAN MODUL EDUKASI ONLINE TENTANG PENCEGAHAN STUNTING DALAM 1000 HARI PERTAMA KEHIDUPAN
Authors: Kurniatin Lydia Febri 
Published: August 2024

Kejadian balita stunting (pendek) merupakan masalah gizi utama yang dihadapi Indonesia. Dalam jangka pendek, stunting dapat meningkatkan kejadian kesakitan dan kematian, perkembangan kognitif, motorik dan verbal yang tidak optimal serta berisiko diabetes hingga kanker di masa depan. Untuk mencegah hal tersebut, diperlukan upaya meningkatkan pengetahuan masyarakat untuk pencegahan stunting khususnya di masa 1000 hari pertama kehidupan. Kelurahan Banjar Serasan dan Saigon merupakan 2 dari 10 Kelurahan fokus intervensi penurunan stunting di Kalimantan Barat. Metode kegiatan PKM ini adalah dengan penyuluhan menggunakan modul online dengan sasaran ibu hamil, ibu yang memiliki balita, dan kader KIA berjumlah 30 orang di masing-masing wilayah kerja Puskesmas Saigon dan Banjar Serasan. Untuk mengevaluasi efektivitas kegiatan, dilakukan pengambilan data dengan kuesioner dan dianalisis. Hasil analisis disimpulkan terdapat perbedaan pengetahuan yang bermakna antara sebelum dan sesudah mendapatkan edukasi dengan media e-modul pendampingan 1000 HPK dengan p value = 0.002.
Peluang, Tantangan Dan Strategi Pengembangan Pariwisata Syariah Berbasis Ekonomi Komunitas Untuk Meningkatkan Daya Tarik Wisatawan Di Desa Tetebatu Kecamatan Sikur Lombok Timur
Authors: Suryaningsih Baiq Ratih , Elbadriati Baiq , Mulhimmah Baiq Ratna , Azkar Muh. 
Published: August 2024

Pariwisata halal telah menjadi tren dalam ekonomi global untuk produk makanan, minuman, keuangan, dan gaya hidup. Salah satu pariwisata halal di NTB yaitu Tetebatu di wilayah Kecamatan Sikur, Lombok Timur. Namun, potensi pariwisata syariah belum dioptimalkan sehingga kurangnya wisatawan lokal berkunjung ke Desa wisata. Penelitian ini bertujuan untuk mengetahui Peluang, Tantangan dan Strategi Pengembangan Pariwisata Syariah Berbasis Ekonomi Komunitas Untuk Meningkatkan Daya Tarik Wisatawan. Pendekatan yang digunakan yakni penelitian kualitatif yang mendeskripsikan objek, fenomena, setting sosial penelitian sesuai fakta dilapangan. Sumber data yakni data primer dan sekunder. Instrumen penelitian peneliti sendiri. Teknik pengumpulan data observasi, wawancara dan dokumentasi. Teknik analisis data redukasi data, penyajian data dan menarik kesimpulan. Teknik keabsahan data triangulasi, deduktif dan penilaian teman sejawat. Hasil penelitian, peluang pengembangan pariwisata syariah; a) Objek wisata sebagai tempat belajar, b) menciptakan kesempatan kerja, c) banyaknya wisatawan yang berkunjung,d) berkembangnya penggiat pariwisata syariah,e) berkembangnya digitalisasi wisata syariah, f) memfasilitasi kebutuhan wisatawan dan memberikan profit daerah wisata. Tantangan pengembangan pariwisata syariah; a) Persaingan daya tarik dan infrastruktur pariwisata syariah, b) minimnya pengetahuan masyarakat tenang pariwisata syariah, c) keterbatasan modal dalam pengembangan, d) wisatawan tidak mengikuti arahan di tempat wisata. Strategi pengembangan pariwisata syariah; a) Memberikan fasilitas dan pelayanan yang baik, b) meningkatkan ciri khas dari daerah wisata, c) mengembangkan koneksi wisata halal, d) mengembangkan promosi dan marketing, e) melakukan pemasaran wisata berdasarkan tujuan asal, waktu, serta preferensi dari pasar travel muslim
RESPON GURU SMA NEGERI PAREPARE TERHADAP PRODUK BANK SYARIAH INDONESIA CABANG PAREPARE
Authors: Bunga Purnamasari , Darmawati Darmawati , Semaun Syahriyah , Muliati Muliati , Bahri S Andi , Musmulyadi Musmulyadi 
Published: August 2024

This thesis discusses the response of high school teachers in Parepare to the products offered by the Indonesian Sharia Bank (BSI) Parepare branch. The purpose of this study is to identify the types of BSI products used by high school teachers in Parepare, to analyze their responses to these products, and to examine the factors influencing their responses.

The research method employed is qualitative, with a phenomenological approach used to describe the phenomena observed in the field. The study involved 15 informants, and data were collected through observations, interviews, and documentation. The data were then analyzed to present findings and draw conclusions.

The results of this study indicate that 1) The types of BSI products used by high school teachers in Parepare include Wadi’ah financing principles, credit products, as well as other Islamic banking services such as savings, financing, and investments, all of which are in accordance with Sharia financial principles. 2) The response of high school teachers in Parepare to the products offered by the BSI Parepare branch varies, but generally shows a positive acceptance. Teachers tend to use BSI products, indicating trust and alignment with the Sharia values they seek. 3) The factors influencing the response of high school teachers in Parepare to BSI products include individual understanding and awareness of Sharia financial principles, personal knowledge, and value considerations. Teachers tend to choose BSI products based on internal deliberations and personal choices, rather than external factors such as recommendations from others.