bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aseptic meningitis with recurrent headache episodes, vomiting, and central fever as first manifestation of isolated neurosarcoidosis: a case report
Authors: Aloizou Athina-Maria , Gabriel Theresa Anne , Lukas Carsten , Gold Ralf , Motte Jeremias 
Published: August 2024

Abstract
Background
Neurosarcoidosis is a rare entity, usually within the context of systematic sarcoidosis. Isolated neurosarcoidosis and especially a manifestation with pachymeningitis is a notable rarity.

Case Report
A 26-year-old patient presented to the emergency department with acute onset, recurrent episodes of occipital headaches spreading over the whole cranium and vomiting without food consumption, for three days. The clinical examination did not reveal any neurological deficits. The laboratory exams showed no pathological findings. A CT examination with angiography did not detect any acute intracranial or vessel pathology. A lumbar puncture was performed to rule out subarachnoid hemorrhage. The results showed a lymphocytic pleocytosis of 400/µL, elevated protein levels of 1077 mg/dL and reduced glucose levels (CSF: 55 mg/dL, Serum: 118 mg/dL). Extensive infectiological examinations did not reveal any signs of infection, including Borrelia spp. and M. tuberculosis. No positive auto-antibodies or vasculitis-related auto-antibodies were detected. The CSF analysis showed negative oligoclonal bands but an isolated increase in β2-microglobulin, neopterin, and IL-2R levels. The MRI examination revealed a dural gadolinium-enhancement, pronounced in the basal cerebral structures and the upper segment of the cervical spine, consistent with neurosarcoidosis. Corticosteroid treatment rapidly led to a significant improvement of the symptoms. No systemic manifestations of sarcoidosis were found.

Conclusions
This case report aims to highlight aseptic meningitis with atypical, acute onset headache attacks as a possible manifestation of isolated neurosarcoidosis. Neurosarcoidosis is a clinical entity that requires prompt treatment to avoid permanent neurological deficits.
The design, implementation, and evaluation of a blended (in-person and virtual) Clinical Competency Examination for final-year nursing students
Authors: Mojtahedzadeh Rita , Toulabi Tahereh , Mohammadi Aeen 
Published: August 2024

Abstract
Introduction
Studies have reported different results of evaluation methods of clinical competency tests. Therefore, this study aimed to design, implement, and evaluate a blended (in-person and virtual) Competency Examination for final-year Nursing Students.

Methods
This interventional study was conducted in two semesters of 2020–2021 using an educational action research method in the nursing and midwifery faculty. Thirteen faculty members and 84 final-year nursing students were included in the study using a census method. Eight programs and related activities were designed and conducted during the examination process. Students completed the Spielberger Anxiety Inventory before the examination, and both faculty members and students completed the Acceptance and Satisfaction questionnaire.

Findings
The results of the analysis of focused group discussions and reflections indicated that the virtual CCE was not capable of adequately assessing clinical skills. Therefore, it was decided that the CCE for final-year nursing students would be conducted using a blended method. The activities required for performing the examination were designed and implemented based on action plans. Anxiety and satisfaction were also evaluated as outcomes of the study. There was no statistically significant difference in overt, covert, and overall anxiety scores between the in-person and virtual sections of the examination (p > 0.05). The mean (SD) acceptance and satisfaction scores for students in virtual, in-person, and blended sections were 25.49 (4.73), 27.60 (4.70), and 25.57 (4.97), respectively, out of 30 points, in which there was a significant increase in the in-person section compared to the other sections. (p = 0.008). The mean acceptance and satisfaction scores for faculty members were 30.31 (4.47) in the virtual, 29.86 (3.94) in the in-person, and 30.00 (4.16) out of 33 in the blended, and there was no significant difference between the three sections (p = 0.864).

Conclusion
Evaluating nursing students’ clinical competency using a blended method was implemented and solved the problem of students’ graduation. Therefore, it is suggested that the blended method be used instead of traditional in-person or entirely virtual exams in epidemics or based on conditions, facilities, and human resources. Also, the use of patient simulation, virtual reality, and the development of necessary virtual and in-person training infrastructure for students is recommended for future research. Furthermore, considering that the acceptance of traditional in-person exams among students is higher, it is necessary to develop virtual teaching strategies.
The role of miR-155-5p in inflammation and mechanical loading during intervertebral disc degeneration
Authors: Cazzanelli Petra , Lamoca Mikkael , Hasler Johannes , Hausmann Oliver Nic , Mesfin Addisu , Puvanesarajah Varun , Hitzl Wolfgang , Wuertz-Kozak Karin 
Published: August 2024

Abstract
Background
Intervertebral disc (IVD) degeneration is a multifactorial pathological process resulting in the dysregulation of IVD cell activity. The catabolic shift observed in IVD cells during degeneration leads to increased inflammation, extracellular matrix (ECM) degradation, aberrant intracellular signaling and cell loss. Importantly, these pathological processes are known to be interconnected and to collectively contribute to the progression of the disease. MicroRNAs (miRNAs) are known as strong post-transcriptional regulators, targeting multiple genes simultaneously and regulating numerous intracellular pathways. Specifically, miR-155-5p has been of particular interest since it is known as a pro-inflammatory mediator and contributing factor to diseases like cancer and osteoarthritis. This study investigated the role of miR-155-5p in IVD degeneration with a specific focus on inflammation and mechanosensing.

Methods
Gain- and loss-of-function studies were performed through transfection of human Nucleus pulposus (NP) and Annulus fibrosus (AF) cells isolated from degenerated IVDs with miR-155-5p mimics, inhibitors or their corresponding non-targeting control. Transfected cells were then subjected to an inflammatory environment or mechanical loading. Conditioned media and cell lysates were collected for phosphorylation and cytokine secretion arrays as well as gene expression analysis.

Results
Increased expression of miR-155-5p in AF cells resulted in significant upregulation of interleukin (IL)-8 cytokine secretion during cyclic stretching and a similar trend in IL-6 secretion during inflammation. Furthermore, miR-155-5p mimics increased the expression of the brain-derived neurotrophic factor (BDNF) in AF cells undergoing cyclic stretching. In NP cells, miR-155-5p gain-of-function resulted in the activation of the mitogen-activated protein kinase (MAPK) signaling pathway through increased phosphorylation of p38 and p53. Lastly, miR-155-5p inhibition caused a significant increase in the anti-inflammatory cytokine IL-10 in AF cells and the tissue inhibitor of metalloproteinases (TIMP)-4 in NP cells respectively.

Conclusion
Overall, these results show that miR-155-5p contributes to IVD degeneration by enhancing inflammation through pro-inflammatory cytokines and MAPK signaling, as well as by promoting the catabolic shift of AF cells during mechanical loading. The inhibition of miR-155-5p may constitute a potential therapeutic approach for IVD degeneration and low back pain.
Turner Syndrome where are we?
Authors: Khan Najma , Farooqui Anam , Ishrat Romana 
Published: August 2024

AbstractTurner syndrome (TS) results from the loss of one X chromosome in phenotypic females, leading to a range of complications such as short stature, cardiovascular issues, autoimmune disorders, metabolic imbalances, osteoporosis, neurocognitive deficits, hearing loss, abnormalities in endocrine functions, infertility, disruptions in bone metabolism, and neurocognitive deficits. These diverse clinical manifestations necessitate a comprehensive and multidisciplinary approach to diagnosis and management. Growth hormone therapy stands out as a fundamental treatment for addressing the challenges associated with TS. Ongoing clinical and genomic advancements contribute to an evolving understanding of TS, shedding light on its complexities and potential therapeutic interventions. Despite progress, further research is crucial to identify candidate pathways and critical biomarkers that can alleviate the syndrome’s burden. By uncovering these insights, we aim to empower individuals with TS, enhancing their overall functioning and quality of life. In this review, we have explored the prevalent co-morbidities associated with TS, drawing insights from the current literature.
Exercise induced hypoalgesia after a high intensity functional training: a randomized controlled crossover study
Authors: Tomschi Fabian , Ransmann Pia , Schmidt Alexander , Hilberg Thomas 
Published: August 2024

Abstract
Background
Acute physical activity often induces an acute reduction in pain sensitivity known as exercise induced hypoalgesia (EIH). The aim of this study was to investigate the effects of a high intensity functional training (HIFT) on EIH compared to a control session.

Methods
50 (age: 26.0 ± 2.7; 23 female) participants successfully conducted this study consisting of a pre-experimental test as well as a 12-minute HIFT (body-weight exercises) and a 12-minute control (supervised breathing) session in a randomized crossover design. Pre and post, pressure pain thresholds (PPT) were measured at the ankles, knees, elbows, and forehead.

Results
The HIFT resulted in a relative maximum and average heart rate of 96.2% (± 3.6%) and 91.1% (± 4.2%), respectively, and maximum and average RPE values of 19.1 (± 1.2) and 16.2 (± 1.4), respectively. Results reveal a significant ‘Intervention’ × ‘Time point’ interaction (p < 0.001) for PPT (pooled for one average value) with hypoalgesia observed following the HIFT (p < 0.001; pre: 56.0 ± 16.8, post: 61.6 ± 19.0 [Newton]) and no change following the control (p = 0.067; pre: 56.6 ± 18.4, post: 55.3 ± 18.9 [Newton]). Further, a significant ‘Time’ × ‘Intervention’ × ‘Landmark’ interaction effect (p = 0.024) is observed and all landmarks showed significant hypoalgesia following HIFT (p < 0.01), except for the right elbow and forehead. Following control, no hypoalgesia was observed at any landmark. Analysing male and female participants separately, it was observed that EIH occured only in men.

Conclusion
A HIFT using bodyweight exercises reduces pain sensitivity. Hence, combining strength and aerobically demanding exercises in a short but high intensity manner, as done in HIFT, can be seen as a usable tool to induce hypoalgesia. Yet, these results were observed only in male participants, necessitating future sex-specific research.

Trial registration
DRKS00034391, retrospectively registered on the 4th of June 2024.
Using Municipal Solid-Waste Incinerator Fly Ash, Wash Water, and Propylene Fibers in Self-Compacting Repair Mortar, Greenhouse Gas Emissions Potential
Authors: Abdi Ehsan , Asadollahfardi Gholamreza , Salehi Amirmasoud , Akbardoost Javad , Esmaeili Negar , Panahandeh Azadeh 
Published: August 2024

AbstractWash water, municipal solid waste incineration (MSWI) fly ash, and propylene (PP) fibers were employed simultaneously to produce self-compacting repair mortar (SCRM). Different SCRM mixtures were utilized, incorporating 35, 70, and 140 kg/m3 of MSWI fly ash, along with 0.1% of PP fibers. The research focused on investigating the workability, mechanical properties, and global warming potential (GWP) of SCRM. The incorporation of MSWI fly ash and wash water in SCRM resulted in reduced workability, necessitating an increase in the use of superplasticizer. Adding MSWI fly ash decreases compressive strength. The minimum compressive strength was observed when employing 140 kg/m3 of MSWI fly ash and wash water instead of tap water simultaneously. By increasing the proportion of MSWI fly ash content and correspondingly reducing the cement content in SCRM samples, there was a decrease in flexural strength. The ultrasonic pulse velocity (UPV) of all SCRM samples falls within acceptable range. Adding MSWI fly ash to SCRM reduces fracture toughness, and the concurrent use of wash water and MSWI fly ash significantly decreases fracture toughness. Incorporating PP fibers into SCRM resulted in increased compressive strength. Utilizing wash water and MSWI fly ash in SCRM significantly reduces GWP. The avoidance of wash water consumption mitigates the environmental impact of SCRM.
A metabolite-based liquid biopsy for detection of ovarian cancer
Authors: Fahrmann Johannes F. , Ghasemi Seyyed Mahmood , Han Chae Y. , Wu Ranran , Dennison Jennifer B. , Vykoukal Jody , Celestino Joseph , Lu Karen , Lu Zhen , Drescher Charles , Do Kim-Anh , Hanash Samir , Bast Robert C. , Irajizad Ehsan 
Published: August 2024

AbstractSerial CA125 and second line transvaginal ultrasound (TVS) screening in the UKCTOCS indicated a shift towards detection of earlier stage ovarian cancer (OvCa), but did not yield a significant mortality reduction. There remains a need to establish additional biomarkers that can complement CA125 for even earlier and at a larger proportion of new cases. Using a cohort of plasma samples from 219 OvCa cases (59 stage I/II and 160 stage III/IV) and 409 female controls and a novel Sensitivity Maximization At A Given Specificity (SMAGS) method, we developed a blood-based metabolite-based test consisting of 7 metabolites together with CA125 for detection of OvCa. At a 98.5% specificity cutpoint, the metabolite test achieved sensitivity of 86.2% for detection of early-stage OvCa and was able to capture 64% of the cases with low CA125 levels (< 35 units/mL). In an independent test consisting of 65 early-stage OvCa cases and 141 female controls, the metabolite panel achieved sensitivity of 73.8% at a 91.4% specificity and captured 13 (44.8%) out of 29 early-stage cases with CA125 levels < 35 units/mL. The metabolite test has utility for ovarian cancer screening, capable of improving upon CA125 for detection of early-stage disease.
Machine Learning–Based Prediction of 1-Year Survival Using Subjective and Objective Parameters in Patients With Cancer
Authors: Salvador Comino Maria Rosa , Youssef Paul , Heinzelmann Anna , Bernhardt Florian , Seifert Christin , Tewes Mitra 
Published: August 2024

PURPOSE Palliative care is recommended for patients with cancer with a life expectancy of <12 months. Machine learning (ML) techniques can help in predicting survival outcomes among patients with cancer and may help distinguish who benefits the most from palliative care support. We aim to explore the importance of several objective and subjective self-reported variables. Subjective variables were collected through electronic psycho-oncologic and palliative care self-assessment screenings. We used these variables to predict 1-year mortality. MATERIALS AND METHODS Between April 1, 2020, and March 31, 2021, a total of 265 patients with advanced cancer completed a patient-reported outcome tool. We documented objective and subjective variables collected from electronic health records, self-reported subjective variables, and all clinical variables combined. We used logistic regression (LR), 20-fold cross-validation, decision trees, and random forests to predict 1-year mortality. We analyzed the receiver operating characteristic (ROC) curve—AUC, the precision-recall curve—AUC (PR-AUC)—and the feature importance of the ML models. RESULTS The performance of clinical nonpatient variables in predictions (LR reaches 0.81 [ROC-AUC] and 0.72 [F1 score]) are much more predictive than that of subjective patient-reported variables (LR reaches 0.55 [ROC-AUC] and 0.52 [F1 score]). CONCLUSION The results show that objective variables used in this study are much more predictive than subjective patient-reported variables, which measure subjective burden. These findings indicate that subjective burden cannot be reliably used to predict survival. Further research is needed to clarify the role of self-reported patient burden and mortality prediction using ML.
Bempedoic acid – new agent in hiperlipidemia treatment – literature review
Authors: Frańczuk Agata , Makłowicz Aleksandra , Plizga Jakub , Głuszczyk Agnieszka , Kopczyńska Ewelina , Szpulak Angelika , Grzelka Michalina , Kuleta Katarzyna , Słychan Katarzyna , Głoskowska Julia 
Published: August 2024

Hyperlipidemia is becoming more and more severe condition among modern society. High-fat diet, sedentary lifestyle, lack of physical activity are the common factors leading to overweight, obesity and problems with serum lipid control. Dyslipidemia is one of the most important agents contributing to cardiovascular diseases snd therefore lower quality of life, disability and preamature death. This forces to constatnt searching for lipid-lowering drugs, that can be successfully use in the patients suffering from poor lipid control. Bempedoic acid (ETC-1020) is one of the newest, first in the class medicine, firstly approved to use in the USA on 21st February 2020 in monotheraphy, and then on 26th February in combination with ezetimibe. It is a small synthetic prodrug molecule that is activated by acyl-CoA synthetase in the liver. Bempedoic acid inhibits competitively adenosine triphosphate citrate lyase (ACL) and as a result it stops the further production of cholesterol and fatty acids. Research shows the ability of ETC-1020 to decline of LDL-C cholesterol up to 24%. It is also responsible for total cholesterol, non-HDL-C, ApoB and hs-CRP reduction. Bempedoic acid is characterized by good pharmacokinetics and pharmacodynamics. ECT-1020 has also a good drug-to-drug interaction profile. Many clinical trials have reported efficacy and safety of use with minimal side effects. Because of its target point is located in the liver and kidney, it can be successfully use in patients with statin intolerance due to bypassing decline of muscle cholesterol biosyntheisis, that is the main cause of musculosketelar adverse effects.
Coopetition in Platform-Based Retailing: On the Platform’s Entry
Authors: Qi Lian , Song Haotian , Xiao Wenqiang 
Published: August 2024

We study the dynamic incentive interactions between a platform and a third-party seller over two stages, where the seller exerts product-value-enhancement effort in the first stage in anticipation of the platform’s potential entry in the second stage. Upon entry, the platform can exert effort to boost the value of the product sold by the platform, with positive spillovers to the value of the product sold by the platform. We show the existence of both the protective and the receptive regimes, characterizing the necessary and sufficient conditions for each regime. These conditions are of thresholds type with respect to the parameters including the degree of spillover, the referral rate, and the competition intensity. In the protective (receptive) regime, the seller is worse (better) off with the platform’s entry than without, thereby distorting effort downward (upward) from the first best to deter (induce) the platform’s entry to the products of intermediate value. Notably, if the spillover effect is negative, only the protective regime will arise. We also provide the necessary and sufficient conditions under which the platform’s nonentry commitment strictly improves the platform’s profits by restoring the seller’s effort to the first best, achieving the win-win outcome for both the platform and the seller. This paper was accepted by Jeannette Song, operations management. Funding: H. Song is partially supported by the Key International Cooperation and Exchange Projects of the NSFC [Grant W2411062] and the Foundation for Innovative Research Groups of the NSFC [Grant 71821002]. Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2023.00260 .
Peran Guru Bimbingan dan Konseling dalam Meningkatkan Motivasi Belajar: Studi Kasus di SMPK St. Yohanes Tilang
Authors: Sombo Maria Yuvensia , Prasetyo Erwin , Rahman Nurdin H. Abd. 
Published: August 2024

Artikel ini berfokus pada kajian tentang bagaimana peran guru bimbingan dan konseling dalam meningkatkan motivasi belajar peserta didik. Belajar adalah usaha yang dapat dilakukan secara sadar oleh peserta didik untuk merubah sikap dan tingkah laku. Dalam meningkatkan perubahan tingkah laku dibutuhkan motivasi. Dalam kegiatan belajar, motivasi merupakan keseluruhan daya penggerak di dalam diri yang menimbulkan kegiatan belajar yang menjamin kelangsungan dari kegiatan belajar. Fenomena yang terjadi di sekolah SMPK St.Yohanes Tilang saat ini adalah banyak peserta didik yang kurang termotivasi dalam belajar. Faktanya dapat diamati dari perilaku peserta didik yang kurang antusias terhadap proses pembelajaran, kurang memperhatikan guru ketika menjelaskan materi,dan enggan mengerjakan tugas yang diberikan oleh guru. Menumbuhkan dan meningkatkan motivasi belajar merupakan tanggung jawab utama para guru, guru BK berkolaborasi dengan guru mata pelajaran, dan guru wali kelas. Peran guru bimbingan dan konseling dalam meningkatkan motivasi belajar yaitu dilakukan dengan layanan informasi. Dengan tujuan untuk memberikan informasi terkait pemahaman yang berhubungan dengan permasalahan yang dihadapi peserta didik. Penelitian ini dilakukan terhadap peserta didik kelas VII,VIII, dan IX, secara acak pada SMPK St. Yohanes Tilang Kecamatan Nita yang mengalami motivasi belajar rendah. Jenis Penelitian ini menggunakan metode kualitatif dengan pendekatan studi kasus, yaitu suatu penelitian lapangan dengan tujuan mendeskripsikan ( memaparkan) semua persoalan - persoalan yang ditemukan di lapangan berupa kata-kata lisan dan tertulis, kata-kata tulisan yakni kutipan – kutipan data dalam bentuk narasi. Adapun pengumpulan data dilakukan melalui observasi, wawancara dan analisis dokumentasi dengan dilakukan Triangulasi sumber sebagai keabsahan data. Setelah memberikan layanan informasi, biasanya guru BK juga akan memberikan pelayanan lanjutan bagi peserta didik yang memiliki permasalahan yang cenderung lebih kompleks terkait dengan informasi yang diberikan. Guru BK akan memberikan layanan bimbingan belajar, bimbingan kelompok, konseling individu atau kelompok sebagai upaya dalam meningkatkan motivasi belajar peserta didik. sehingga membawa perubahan dalam diri peserta didik yaitu menjadi semangat dalam belajar.