bluuebunny/crossref_metadata_2025_split huggingface dataset:
The evaluation of cardiac tamponade risk in patients with pericardial effusion detected by non-gated chest CT
Authors: Ohta Yasutoshi , Miyoshi Fuminori , Kaminou Toshio , Kaetsu Yasuhiro , Ogawa Toshihide 
Published: July 2015

Background Although pericardial effusion is often identified using non-gated chest computed tomography (CT), findings predictive of cardiac tamponade have not been adequately established. Purpose To determine the findings predictive of clinical cardiac tamponade in patients with moderate to large pericardial effusion using non-gated chest CT. Material and Methods We performed a retrospective analysis of 134 patients with moderate to large pericardial effusion who were identified from among 4581 patients who underwent non-gated chest CT. Cardiac structural changes, including right ventricular outflow tract (RVOT), were qualitatively evaluated. The inferior vena cava ratio with hepatic (IVCupp) and renal portions (IVClow) and effusion size were measured. The diagnostic performance of each structural change was calculated, and multivariate analysis was used to determine the predictors of cardiac tamponade. Results Of the 134 patients (mean age, 70.3 years; 64 men), 37 (28%) had cardiac tamponade. The sensitivity and specificity were 76% and 74% for RVOT compression; 87% and 84% for an IVClow ratio ≥0.77; and 60% and 77% for an effusion size ≥25.5 mm, respectively. Multivariate logistic regression analysis demonstrated that RVOT compression, an IVClow ratio ≥0.77, and an effusion size ≥25.5 mm were independent predictors of cardiac tamponade. The combination of these three CT findings had a sensitivity, specificity, and accuracy of 81%, 95%, and 91%, respectively. Conclusion In patients with moderate to large pericardial effusion, non-gated chest CT provides additional information for predicting cardiac tamponade.
Use of occupation-focused language by occupational therapists in physical health care settings when considering older people and alcohol use
Authors: Maclean Fiona , Breckenridge Jenna 
Published: July 2015

Statement of context There is ongoing debate about therapists’ use of occupation-focused language in practice. Through practice language analysis we explored how conceptual models influence therapists’ word choice by re-analysing qualitative data from a survey of occupational therapists’ knowledge and beliefs about alcohol use amongst older people. Critical reflection on practice We used word clouds to analyse practitioners’ responses about whether they used conceptual models in practice. We reflect on three themes: theories that mirror the realities of practice; shaping theories in action; and ‘considered’ practice. Implications for practice Conceptual models shape, and are shaped by, the language of practice. This provides insight into the relationship between models, language and professional identity.
Gut feelings 2. Mind, mood and gut in inflammatory bowel disease: approaches to psychiatric care
Authors: Keightley Philip , Pavli Paul , Platten Jan , Looi Jeffrey CL 
Published: July 2015

Objectives: The authors aim to provide a clinically-focused summary of psychiatric complications of inflammatory bowel disease (IBD), and give treatment recommendations. A narrative review of literature drawn from PubMed and Medline. Conclusions: IBD is a chronic, debilitating and potentially body integrity altering condition with significant morbidity and a slight increase in mortality. Co-morbidity with anxiety and depression is common. Onset in the younger years can disturb development. Psychotherapy may be most useful for addressing fatigue, pain and assisting with coping. There is a lack of evidence to guide treatment of depression in this population.
Nitric Oxide, Inflammation, Lipid Profile, and Cortisol in Normal- and Overweight Women With Fibromyalgia
Authors: Rus Alma , Molina Francisco , Gassó Manuela , Camacho Maria Victoria , Peinado Maria Ángeles , Moral Maria Luisa del 
Published: July 2015

Objectives: Research has identified many factors associated with fibromyalgia (FM), but findings have been inconsistent. This study aimed to investigate changes in levels of nitric oxide (NO), inflammatory markers, lipid profile, and cortisol in normal- and overweight patients with FM and controls. Since most patients with FM are overweight, we explored possible changes in these markers according to body mass index (BMI). Methods: This preliminary study was performed on serum samples of women with FM and age-matched controls, grouped according to their BMI: 12 normal-weight patients and 12 controls and 13 overweight patients and 8 controls. Ozone-based chemiluminescence assay was used to measure NO. Inflammatory mediators and cortisol were determined by immunoassay. Lipid profile was measured by a spectrophotometric procedure. Functional capacity was assessed by the fibromyalgia impact questionnaire (FIQ). Results: Normal-weight patients showed higher levels of C-reactive protein (CRP) and apolipoprotein B compared to controls (both p < .05). CRP, apolipoprotein B, and triglycerides were higher in overweight patients versus overweight controls (all p < .05) and in overweight versus normal-weight patients (CRP p < .01; apolipoprotein B, triglycerides p < .05). The other markers were unaffected. Apolipoprotein B ( r = .762; p < .05) and NO ( r = −.921; p < .05) levels correlated with FIQ score in normal-weight patients. CRP level correlated with FIQ ( r = .912; p < .05) in overweight patients. Conclusions: CRP and apolipoprotein B, biomarkers linked to cardiovascular events, may be associated with FM-related dysfunction in normal- and overweight women with FM. Their increased levels in these patients may indicate an increased risk of cardiovascular disease.
Step-and-Shoot IMRT by Siemens Beams
Authors: Russo M. , Piermattei A. , Greco F. , Azario L. , Orlandini L. , Zucca S. , Cilla S. , Menna S. , Grusio M. , Chiatti L. , Fidanzio A. 
Published: July 2015

Purpose: This work reports the extension of a semiempirical method based on the correlation ratios to convert electronic portal imaging devices transit signals into in vivo doses for the step-and-shoot intensity-modulated radiotherapy Siemens beams. The dose reconstructed at the isocenter point Diso, compared to the planned dose, Diso,TPS, and a γ-analysis between 2-dimensional electronic portal imaging device images obtained day to day, seems to supply a practical method to verify the beam delivery reproducibility. Method: The electronic portal imaging device images were obtained by the superposition of many segment fields, and the algorithm for the Diso reconstruction for intensity-modulated radiotherapy step and shoot was formulated using a set of simulated intensity-modulated radiotherapy beams. Moreover, the in vivo dose-dedicated software was integrated with the record and verify system of the centers. Results: Three radiotherapy centers applied the in vivo dose procedure at 30 clinical intensity-modulated radiotherapy treatments, each one obtained with 5 or 7 beams, and planned for patients undergoing radiotherapy for prostatic tumors. Each treatment beam was checked 5 times, obtaining 900 tests of the ratios R = Diso/Diso,TPS. The average R value was equal to 1.002 ± 0.056 (2 standard deviation), while the mean R value for each patient was well within 5%, once the causes of errors were removed. The γ-analysis of the electronic portal imaging device images, with 3% 3 mm acceptance criteria, showed 90% of the tests with Pγ < 1 ≥ 95% and γmean ≤ 0.5. The off-tolerance tests were found due to incorrect setup or presence of morphological changes. This preliminary experience shows the great utility of obtaining the in vivo dose results in quasi real time and close to the linac, where the radiotherapy staff may immediately spot possible causes of errors. The in vivo dose procedure presented here is one of the objectives of a project, for the development of practical in vivo dose procedures, financially supported by the Istituto Nazionale di Fisica Nucleare.
First report of Cylicospirura felineus in a feral domestic shorthair cat in North America
Authors: Crossland Nicholas A , Hanks Cory R , Ferguson Jayde A , Kent Michael L , Sanders Justin L , Del Piero Fabio 
Published: July 2015

Case summary A feral domestic shorthair cat was euthanized owing to acute onset and progression of neurological signs attributed to ethylene glycol toxicity. At post-mortem examination two nodules were identified within the fundus of the stomach. Examination of the gastric nodules revealed an intact mucosal surface, each with multiple red slender nematodes extending through an individual central pore. Histopathological evaluation of the nodules highlighted unique reactive fibroplasia, mimicking feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF), encasing numerous nematodes with females possessing gravid uteri containing abundant larvated eggs. The latter findings were highly suggestive of the Cylicospirura genus, further supported by an en face evaluation of the buccal cavity, highlighting a distinctive trifid tooth appearance. Together, these findings are consistent with Cylicospirura felineus. PCR for the COX-1 gene was unsuccessful on formalin-fixed specimens, attributed to nucleic acid and protein crosslinking. Relevance and novel information This represents the first documented case of Cylicospirura species in a feral domestic shorthair cat in North America. This particular cat lived in the highly urban environment of New Orleans, Louisiana. Identification of this case demonstrates the potential for feral cats to serve as reservoir hosts and ultimately support transmission of Cylicospirura species into domesticated cat populations. Gastric cylicospiruriasis may present clinically as a firm abdominal mass, potentially with a history of chronic vomiting. The latter emphasizes the importance of differentiating this condition from a neoplastic process such as alimentary lymphoma and adenocarcinoma. Histologically, the unique thick anastomosing collagenous cords encasing nematodes represent a stereotypical response observed in a broad array of gastrointestinal inflammation in felines, including intralesional bacteria, fungal hyphae, foreign bodies and, in this case, gastric nematodes that closely resemble FGESF. Additionally, these unique histological lesions have previously been misinterpreted as neoplastic conditions, including sclerosing mast cell tumor and extraosseous osteosarcoma.
First case of feline leishmaniosis caused by Leishmania infantum genotype E in a cat with a concurrent nasal squamous cell carcinoma
Authors: Maia Carla , Sousa Cristina , Ramos Cláudia , Cristóvão José Manuel , Faísca Pedro , Campino Lenea 
Published: July 2015

Case summary This is the first clinical report of feline viscerocutaneous leishmaniosis caused by Leishmania infantum genotype E associated with an invasive squamous cell carcinoma (SCC) in a domestic cat from Portugal. Initially, the cat presented a single cutaneous lesion in the right nostril. A fine-needle aspiration was performed and Leishmania amastigotes were observed without the presence of cells compatible with neoplasia. Systemic treatment with allopurinol was started. One year later, the cat presented a crateriform non-encapsulated and badly delineated mass in the nasal planum, with naso-oral fistulation and nasal destruction. Histologically, the skin mass consisted on an ulcerative plaque-like lesion with a nasal SCC. Leishmania infantum MON-1 parasites were detected by histopathology, culture and PCR of the skin mass, submandibular and popliteal lymph nodes, liver and spleen. Restriction enzyme analysis revealed genotype E, previously identified in humans and dogs living in the same region. Relevance and novel information This is, to the best of our knowledge, the first clinical report of feline viscerocutaneous leishmaniosis caused by L infantum genotype E. The detection and isolation of parasites from a cat that are genetically identical to the ones obtained from humans and dogs with visceral leishmaniosis highlights the need to clarify whether cats play a role in the epidemiology of this parasitic zoonosis. From a clinical point of view, this case reinforces the importance of including leishmaniosis in the differential diagnoses of feline pathology, especially in cats with cutaneous lesions.
FXIa and platelet polyphosphate as therapeutic targets during human blood clotting on collagen/tissue factor surfaces under flow
Authors: Zhu Shu , Travers Richard J. , Morrissey James H. , Diamond Scott L. 
Published: July 2015

Key Points
Contribution of FXIa and platelet-derived polyphosphate in thrombin generation varies depending on surface tissue-factor level. Platelet-derived polyphosphate potentiates pathways downstream of FXIIa that require low participation of extrinsic pathways.
Facile Synthesis of Mn-Doped ZnO Porous Nanosheets as Anode Materials for Lithium Ion Batteries with a Better Cycle Durability
Authors: Wang Linlin , Tang Kaibin , Zhang Min , Xu Jingli 
Published: July 2015

Abstract
Porous Zn1 − x
Mn
x
O (x = 0.1, 0.2, 0.44) nanosheets were prepared by a low-cost, large-scale production and simple approach, and the applications of these nanosheets as an anode material for Li-ion batteries (LIBs) were explored. Electrochemical measurements showed that the porous Zn0.8Mn0.2O nanosheets still delivered a stable reversible capacity of 210 mA h g−1 at a current rate of 120 mA g−1 up to 300 cycles. These results suggest that the facile synthetic method of producing porous Zn0.8Mn0.2O nanostructure can realize a better cycle durability with stable reversible capacity.
The clinical relevance of animal models in Sjögren’s syndrome: the interferon signature from mouse to man
Authors: Maria Naomi I , Vogelsang Petra , Versnel Marjan A 
Published: July 2015

AbstractMouse models have been widely used to elucidate the pathogenic mechanisms of human diseases. The advantages of using these models include the ability to study different stages of the disease with particular respect to specific target organs, to focus on the role of specific pathogenic factors and to investigate the effect of possible therapeutic interventions. Sjögren’s syndrome (SS) is a systemic autoimmune disease, characterised by lymphocytic infiltrates in the salivary and lacrimal glands. To date, effective therapy is not available and treatment has been mainly symptomatic. Ongoing studies in murine models are aimed at developing more effective and targeted therapies in SS. The heterogeneity of SS will most probably benefit from optimising therapies, tailored to specific subgroups of the disease. In this review, we provide our perspective on the importance of subdividing SS patients according to their interferon signature, and recommend choosing appropriate mouse models for interferon-positive and interferon-negative SS subtypes. Murine models better resembling human-disease phenotypes will be essential in this endeavour.
α-$(\psi,\phi)$ Contractive mappings on quasi-partial metric spaces
Authors: Karapınar Erdal , Gholizadeh Leila , Alsulami Hamed H , Noorwali Maha 
Published: July 2015

AbstractIn this paper, we consider α-$(\psi,\phi)$
(
ψ
,
ϕ
)
contractive mappings in the setting of quasi-partial metric spaces and verify the existence of a fixed point on such spaces. Moreover, we present some examples and applications in integral equations of our obtained results.
Antidiabetic, antioxidant, antihyperlipidemic effect of extract of Euryale ferox salisb. with enhanced histopathology of pancreas, liver and kidney in streptozotocin induced diabetic rats
Authors: Ahmed Danish , Kumar Vikas , Verma Amita , Shukla Girija Shankar , Sharma Manju 
Published: July 2015

Abstract
Background
Ethanolic extract of Euryale ferox salisb. (EFx) may have an effect on the activity of hepatic antioxidant enzymes, glycemic control and lipid profile and histopathology of pancreas, liver and kidney of streptozotocin (STZ)—induced diabetic wistar rats.

Methods
Wistar albino rats were divided into eight groups viz. non-diabetic (normal control), diabetic control (STZ-induced), diabetic treated (infused with different doses of Euryale ferox. Salisb. ethanolic extract) and diabetic conventional treated (treated with Glibenclamide). Diabetes was induced by administering streptozotocin (60 mg/kg body weight) intraperitoneal (i.p). The ethanolic extract was supplemented in different doses through oral route. Biochemical investigations were carried out according to previously reported methods. Histopathological examinations were done accordingly.

Results
The EFx supplemented diabetic rats significantly (p < 0.001) decreased the blood glucose level in a dose dependent manner. Plasma insulin level was significantly increased in EFx treated rats. The hepatic gluconeogenic enzymes activities were restored to normal in EFx treated rats. Activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) were significantly increased (p < 0.001) among EFx treated rats. Lipid profile was reinstated to nearly normal level among EFx treated rats. Histopathological investigations revealed that microscopic architecture of pancreatic, hepatic and renal cells improvised in EFx treated diabetic rats.

Conclusion
EFx supplement could improve the glycemic control as well as lipid profile in diabetic rats along with improvised antioxidant enzymes which has beneficial effect in preventing the diabetic complications by scavenging the free radicals in diabetic rats.
GPU-enabled particle-particle particle-tree scheme for simulating dense stellar cluster system
Authors: Iwasawa Masaki , Portegies Zwart Simon , Makino Junichiro 
Published: July 2015

AbstractWe describe the implementation and performance of the $\mathrm {P}^{3}\mathrm{T}$

P
3

T
(Particle-Particle Particle-Tree) scheme for simulating dense stellar systems. In $\mathrm{P}^{3}\mathrm{T}$

P
3

T
, the force experienced by a particle is split into short-range and long-range contributions. Short-range forces are evaluated by direct summation and integrated with the fourth order Hermite predictor-corrector method with the block timesteps. For long-range forces, we use a combination of the Barnes-Hut tree code and the leapfrog integrator. The tree part of our simulation environment is accelerated using graphical processing units (GPU), whereas the direct summation is carried out on the host CPU. Our code gives excellent performance and accuracy for star cluster simulations with a large number of particles even when the core size of the star cluster is small.
Natural killer (NK) cells and anti-tumor therapeutic mAb: unexplored interactions
Authors: Battella Simone , Cox Maria Christina , Santoni Angela , Palmieri Gabriella 
Published: July 2015

Abstract
Tumor-targeting mAb are widely used in the treatment of a variety of solid and hematopoietic tumors and represent the first immunotherapeutic approach successfully arrived to the clinic. Nevertheless, the role of distinct immune mechanisms in contributing to their therapeutic efficacy is not completely understood and may vary depending on tumor- or antigen/antibody-dependent characteristics. Availability of next-generation, engineered, tumor-targeting mAb, optimized in their capability to recruit selected immune effectors, re-enforces the need for a deeper understanding of the mechanisms underlying anti-tumor mAb functionality. NK cells participate with a major role to innate anti-tumor responses, by exerting cytotoxic activity and producing a vast array of cytokines. As the CD16 (low-affinity FcγRIIIA)-activating receptor is expressed on the majority of NK cells, its effector functions can be ideally recruited against therapeutic mAb-opsonized tumor cells. The exact role of NK cells in determining therapeutic efficacy of tumor-targeting mAb is still unclear and much sought after. This knowledge will be instrumental to design innovative combination schemes with newly validated immunomodulatory agents. We will summarize what is known about the role of NK cells in therapeutic anti-tumor mAb therapy, with particular emphasis on RTX chimeric anti-CD20 mAb, the first one used in clinical practice for treating B cell malignancies.
The importance of indifference in scientific research
Authors: Schwartz Martin A. 
Published: July 2015

Current issues regarding scientific ethics have focused for the most part on regulations governing research and publication. I suggest that the internal process by which we separate self interest from the scientific process is a crucial and neglected part of training. Consideration of these issues might help us train better scientists instead of just scientists who adhere to the rules.
This is a follow-up to the essay ‘The importance of stupidity in scientific research’ by Martin A. Schwartz (J. Cell Sci. 121, 1771).
We Study Russian People’s History by Means of Fairy Tale
Authors: Горбаткина  , Gorbatkina Irina 
Published: July 2015

A problem of folklore and authors’ fairy tales use as means of junior schoolchildren acquaintance with the Russian people’s history and household
culture is discussed in this paper. Examples of fairy tales and technique of work with outdated terms and concepts which meet in these fairy tales
are given. Material can widely be used at world around lessons when studying corresponding historical subjects.
The identification of research priorities for UK occupational therapists in work rehabilitation
Authors: Coole Carol , McBean Juliet , Drummond Avril , Reagon Carly 
Published: July 2015

Background/Aims: UK occupational therapists are recognised as having key skills in work rehabilitation, but there is limited evidence to underpin this. In order to use research resources to best effect, it is vital to identify the research priorities of occupational therapists in work rehabilitation. This study aims to gather the views of those with a special interest in the field in order to identify their research priorities. Methods: An online survey was developed and administered electronically to members (n=173) of the College of Occupational Therapists Specialist Section–Work (COTSS–Work). Respondents were asked to: i) prioritise and comment on research areas; ii) propose research questions. A final sample of 42 surveys was collected and analysed thematically. Results: Responses reflected the diversity and complexity of work rehabilitation. Identifying a rank order of research priorities proved challenging as the majority (≥62%) of respondents considered all of the topic areas listed a high priority. Research into the following areas were included in the survey: interventions; outcome measurements; assessments; management and/or service delivery; planning and/or commissioning; and education. However, ‘interventions’ was rated highest overall. Conclusions: Occupational therapists in the UK need more evidence to justify their role in the work and health arena. Greater opportunities are required for occupational therapists in clinical practice, as well as those involved in research, to address areas in which evidence-based practice is lacking and the mechanisms to disseminate this knowledge base.