bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer
Authors: Granados-Principal Sergio , Liu Yi , Guevara Maria L , Blanco Elvin , Choi Dong Soon , Qian Wei , Patel Tejal , Rodriguez Angel A , Cusimano Joseph , Weiss Heidi L , Zhao Hong , Landis Melissa D , Dave Bhuvanesh , Gross Steven S , Chang Jenny C 
Published: February 2015

Abstract
Introduction
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with no effective targeted therapy. Inducible nitric oxide synthase (iNOS) is associated with poor survival in patients with breast cancer by increasing tumor aggressiveness. This work aimed to investigate the potential of iNOS inhibitors as a targeted therapy for TNBC. We hypothesized that inhibition of endogenous iNOS would decrease TNBC aggressiveness by reducing tumor initiation and metastasis through modulation of epithelial-mesenchymal transition (EMT)-inducing factors.

Methods
iNOS protein levels were determined in 83 human TNBC tissues and correlated with clinical outcome. Proliferation, mammosphere-forming efficiency, migration, and EMT transcription factors were assessed in vitro after iNOS inhibition. Endogenous iNOS targeting was evaluated as a potential therapy in TNBC mouse models.

Results
High endogenous iNOS expression was associated with worse prognosis in patients with TNBC by gene expression as well as immunohistochemical analysis. Selective iNOS (1400 W) and pan-NOS (L-NMMA and L-NAME) inhibitors diminished cell proliferation, cancer stem cell self-renewal, and cell migration in vitro, together with inhibition of EMT transcription factors (Snail, Slug, Twist1, and Zeb1). Impairment of hypoxia-inducible factor 1α, endoplasmic reticulum stress (IRE1α/XBP1), and the crosstalk between activating transcription factor 3/activating transcription factor 4 and transforming growth factor β was observed. iNOS inhibition significantly reduced tumor growth, the number of lung metastases, tumor initiation, and self-renewal.

Conclusions
Considering the effectiveness of L-NMMA in decreasing tumor growth and enhancing survival rate in TNBC, we propose a targeted therapeutic clinical trial by re-purposing the pan-NOS inhibitor L-NMMA, which has been extensively investigated for cardiogenic shock as an anti-cancer therapeutic.
Common coupled fixed point theorems for Geraghty-type contraction mappings using monotone property
Authors: Kadelburg Zoran , Kumam Poom , Radenović Stojan , Sintunavarat Wutiphol 
Published: February 2015

AbstractIn this paper, we prove common coupled fixed point theorems under a Geraghty-type condition using monotone instead of the often used mixed monotone property. Also we give some sufficient conditions for the uniqueness of a common coupled fixed point. An example illustrating our results is provided.
Designing a collaborative visual analytics system to support users’ continuous analytical processes
Authors: Jeong Dong Hyun , Ji Soo-Yeon , Suma Evan A , Yu Byunggu , Chang Remco 
Published: February 2015

AbstractIn recent, numerous useful visual analytics tools have been designed to help domain experts solve analytical problems. However, most of the tools do not reflect the nature of solving real-world analytical tasks collaboratively because they have been designed for single users in desktop environments. In this paper, a complete visual analytics system is designed for solving real-world tasks having two integrated components: a single-user desktop system and an extended system suitable for a collaborative environment. Specifically, we designed a collaborative touch-table application (iPCA-CE) by adopting an existing single-user desktop analytical tool (iPCA). With the system, users can actively transit from individual desktop to shared collaborative environments without losing track of their analysis. They can also switch their analytical processes from collaborative to single-user workflows. To understand the usefulness of the system for solving analytical problems, we conducted a user study in both desktop and collaborative environments. From this study, we found that both applications are useful for solving analytical problems individually and collaboratively in different environments.
Optimizing Smart Pump Technology by Increasing Critical Safety Alerts and Reducing Clinically Insignificant Alerts
Authors: Mansfield Jennifer , Jarrett Steven 
Published: February 2015

Background Alerts generated by intravenous (IV) infusion pump safety software prevent life-threatening situations that might otherwise go unnoticed. However, when alerts are often clinically insignificant, health care workers may become desensitized and discount their importance, resulting in potentially dangerous situations. Little research has been devoted to visual alert desensitization. Method This paper describes how the Carolinas HealthCare System decreased the number of nonclinically relevant infusion pump alerts by analyzing alert data that were formatted into scatter plots. This in turn enabled the identification of the medications associated with the most meaningful alerts and those associated with the least meaningful alerts. Conclusion By revising drug library limits for specific medications, it was possible to decrease the number of less clinically meaningful alerts, reduce alert fatigue, and thereby increase the effectiveness of the smart infusion pumps. This added another layer of safety to patient care.
Near-Miss Transcription Errors: A Comparison of Reporting Rates between a Novel Error-Reporting Mechanism and a Current Formal Reporting System
Authors: South David A. , Skelley Jessica W. , Dang Mary , Woolley Thomas 
Published: February 2015

Purpose The medication use process comprises several steps. In institutions without full implementation of computerized prescriber order entry (CPOE), transcription is a critical step in this process. As focus is increasingly placed on identifying near-miss errors, this study aimed to compare near-miss transcription error (NMTE) reporting rates between an institution's formal reporting system and an NMTE reporting mechanism. Methods Two NMTE reporting mechanisms were assessed for 3 months. These mechanisms included the institution's formal error-reporting system and a specific transcription error queue within the institution's order imaging software. Date, patient-care unit, and type of transcription error were recorded for each order image in the transcription error queue and for each transcription error reported formally. Following data collection, reporting rates for both systems were compared. Results Data collection spanned 92 days and an estimated 460,000 medication orders. In total, 1,563 NMTEs were reported using the transcription error queue and 12 errors were reported via the formal reporting mechanism. Of the 1,563 errors identified via the transcription error queue, 325 (20.79%) were of an unknown type. Reporting rates (with unknown errors removed) were 0.27% and 0.0026% for the novel system and formal reporting system, respectively ( P < .001). Conclusion Significantly more NMTEs were reported utilizing the novel system compared with the formal reporting system.
Application and Interview Features Used to Assess Applicant Qualifications for Residency Training
Authors: Butts Allison R. , Smith Kelly M. 
Published: February 2015

Purpose To determine what factors residency program directors (RPDs) consider and what methods they use to assess applicants. Methods Respondents ranked the importance of 27 applicant features within domains: academics/credentials, application features/program fit, involvement, professional experience, research/ teaching experience, and postgraduate year 1 (PGY-1) residency experience. Rank was assigned in an ordinal fashion (1 = most important feature). The domains were characterized by their importance (mean % ± SD) in selecting candidates for interviews. Participants characterized their screening process according to 8 application and 6 interview features and the corresponding applicant dimensions evaluated. RPDs rated the importance of 14 methods applicants used to communicate with the program and 3 methods by which references were obtained. A Likert scale was used for rating (4 = crucial features). The approaches the program used to evaluate 12 application features or interpersonal interactions were reported. Results The most important application domain was application features/program fit (26.28 ± 19.11). The highest ranked application feature was program fit (2.04 ± 1.17). The applicant's cover letter, recommendation letters, curriculum vitae, and interview meal were commonly used to assess communication and interpersonal skills, knowledge base, and experience. The most important communication venue was the on-site interview (3.95 ± 0.23). Recommendations solicited by RPDs (3.42 ± 0.69) were most important. Programs formally evaluated the interview (89%) and recommendation letters (84%). Conclusion Understanding the importance that RPDs place on application and interview features, as well as the process used to assess communication skills and interpersonal interactions, should allow residency candidates to become more competitive residency prospects.
Implementation of a 24-Hour Pharmacy Service with Prospective Medication Review in the Emergency Department
Authors: Sin Billy , Yee Linda , Claudio-Saez Maria , Halim Qazi , Marshall Lewis , Hayes-Quinn Mary 
Published: February 2015

Background It is reported that more than 128 million patients are seen in emergency departments (EDs) annually. Patient overcrowding had been associated with an increased occurrence of medication errors. Purpose Due to increased patient volume and the need for improved patient safety, a 24-hour pharmacy service was established for our institution's ED. The purpose of the study is to quantify and demonstrate the impact of a 24-hour pharmacy service in an urban ED. Methods This was a retrospective descriptive study conducted at a regional level 1 trauma center. The study period occurred between December 2012 and July 2013. The following variables were quantified and analyzed: number of medication orders reviewed, number of intravenous medications compounded, and number of clinical interventions that were recommended by the ED pharmacy team (EDPT) and accepted by ED clinicians. Results A total of 3,779 medication orders were reviewed by the EDPT. Of these orders, 3,482 (92%) were prospectively reviewed. A total of 3,068 (81.2%) and 711 (18.8%) orders were reviewed for the adult and pediatric ED, respectively. During the study period, the EDPT procured 549 intravenous admixtures and conducted 642 clinical interventions. Most of the interventions involved providing drug information for physicians and nurses (45.9%), adjusting drug dosages (21.1%), and recommending antimicrobial therapy (15.1%). Conclusion The implementation of a 24-hour pharmacy service at our institution was an innovative practice that increased the role of pharmacists in the ED. The EDPT conducted prospective medication review, procured intravenous admixtures from a sterile environment, and provided therapeutic recommendations for the ED interdisciplinary team.
Today and yesterday, forever: Negotiating time and space in the art of Mame-Diarra Niang and Dineo Seshee Bopape
Authors: Whitley Zoé 
Published: February 2015

Abstract
Juxtaposing recent site-responsive art installations by artists Mame-Diarra Niang (b.1982, France) and Dineo Seshee Bopape (b.1981, South Africa), this article explores the various geographic, virtual and cultural spaces that the artists simultaneously inhabit in their respective practices. Through interviews with the artists and contextual analysis of their recent projects, one can begin to understand the complex strategies each artist brings to bear to communicate compellingly beyond standard conceptions of past, present and future. Particular attention will be paid to Niang’s Dak’Art 2014 performance Éthéré, which offered a subtle yet trenchant critique of homophobia and related hate crimes in Senegal. Bopape’s aesthetic, meanwhile, exemplified in installations such as but that is not the important part of the story draws on references including slave rebellion and Shembe religious rites. This article will argue that their individual approaches in fact share a number of affinities that can prove revelatory in our understanding of black hauntology, mining the ways in which contemporary African artists alternately negotiate spaces – whether physical, virtual or recorded – and memory.
Afro cyber resistance: South African Internet art
Authors: Rezaire Tabita 
Published: February 2015

Abstract
Looking at the digital–cultural–political means of resistance and media activism on the Internet, this article explores Internet art practices in South Africa as a manifestation of cultural dissent towards western hegemony online. Confronting the unilateral flow of online information, Afro Cyber Resistance is a socially engaged gesture aiming to challenge the representation of the African body and culture through online project. Talking as examples the WikiAfrica project, Cuss Group’s intervention Video Party 4 (VP4) and VIRUS SS 16 by artiste Bogosi Sekhukhuni, this article attempts to demonstrate that the use of the Internet as a medium for digital cultural production and as a platform of dissemination is crucial to raise social awareness and defy African stereotypes and misrepresentation. Creating a unique visual language using the ‘global’ aesthetics of the Internet, yet rooted in African culture, these works deeply reflect on the social environment they spawn from and therefore act as cultural and visual resistance.
Digital hustling: ICT practices of hip hop artists in Grahamstown
Authors: Schoon Alette 
Published: February 2015

Abstract
Hip hop artists are early adopters of digital media in the township areas of Grahamstown. This article describes the emergence of particular media ecologies that depend on a do-it-yourself ethic where young people are always ‘hustling’ to get hold of data bundles, software and computer parts, and assembling them in novel ways. This mobile-first generation are increasingly adopting desktop and laptop computers to supplement their media production, and could provide insights into the evolution of low-income digital media practices and the transition from mobile-only to mobile-first (computer-second) practices, as well as how the computer’s increased affordances for production influence such digital media practices. Living in backyard shacks made from corrugated iron and mud, where there are makeshift electrical connections criss-crossing the roof and no flowing water inside, here there is indeed Internet connectivity, although exclusively through the mobile phone. These hip hop artists are supported by various digital service providers, such as WAP-site designers who hack together sites that function both to promote and distribute local media as well as pirated content, to backyard computer repairers who cannibalize parts from discarded old PCs to create workable township machines. This article will provide a digital ethnography of these young people and how they work collectively to record and mix music, design posters, album covers and avatars, and then distribute these through their phones via Bluetooth and online social media. The article will tie these digital practices to the identity formation of these young people, who resist ­succumbing to the despair of unemployment through embracing notions of themselves as artists, hustlers and ‘explorers of technology’, identities they attribute to the local culture of hip hop music production and its values of consciousness, creativity and resilience.
Cut and paste
Authors: Lokko Lesley 
Published: February 2015

Abstract
mim•ic•ry (n.pl.mim•ic•ries)
1. (a) the art, practice, or art of mimicking;
(b) an instance of mimicking.
2. Biology: The resemblance of one organism to another, or to an object in its surroundings for concealment and protection from predators. In evolutionary biology, mimicry is a similarity of one species to another, which protects one or both. This similarity can be in appearance, behaviour, sound, scent or location. Mimics are typically found in the same areas as their models.
The pervasive condition of African architectural education and practice is one of mimicry, in which students and architects are (sub-consciously) driven to copy ‘solutions’ posed by practitioners outside the continent, most typically European or American, whose understanding and experience of Africa is often limited in nature. Wired, switched-on and connected, current and future young African architects are able, at the click of a finger, to peruse the ‘appearance, behaviour and [even] scent and sound’ of buildings and architectural projects that they may never experience ‘in the flesh’, but whose form, material and programmes are multiplying across the continent in ways and places that their original ‘makers’ could not possibly have imagined. Maboneng is now ‘the Manhattan of Africa’; Kigali its Singapore. Unlike biological mimics, in this context a ‘cut-and-paste’ approach neither protects nor conceals: it simply exposes. As far back as 1997, the Dutch architect and theorist, Rem Koolhaas, argued that it had become increasingly important for architects to operate on a level independent of architecture in order to understand, at the most basic level, the phenomena affecting the development of architecture and the city. In this article, rather than treat ‘cut-and-paste’ as pastiche, a quick-fix intervention that solves the ‘problem’ of original thinking, a new proposition for An Architectural Brief, for An (as yet) Unnamed African Architectural Student, in An (as yet) Unnamed African Location is proposed which fuses art, culture and digital technology to demand a radical, post-Afro urban example.
Technology arts education in South Africa: Mutant collaborations
Authors: Doherty Christo , Bristow Tegan 
Published: February 2015

Abstract
This article addresses Technology Arts Education in South Africa, in particular the case of the development and mutant growth of the Digital Arts department at the University of the Witwatersrand in Johannesburg from 2003 to present. The article addresses the difficulties of working in a strongly discipline-orientated university system, and the small but fascinating successes that have led to major developments in the department. The focus is on the mechanisms of collaboration that have both evolved and been purposefully put in place for a trans-disciplinary education structure to be successfully run. These exist between subject divisions in the School of Arts; and further between the Faculty of Humanities (in which the Digital Arts department is housed) and the Faculty of Engineering, at the University of the Witwatersrand. We address historical collaborations and how these allowed for further developments across disciplines. Through a process of unpacking and presenting, we explore the errors and identify those aspects that we feel are still missing. These include a focus on concepts that have been passed over due to issues around course structure and discipline ownership. We conclude with a look to the future, to opportunities to develop uniquely African Digital Arts practice.
Consciousness displaced: Art and technology education/collaboration for an aesthetic of liberation
Authors: Quinteros Alejandro 
Published: February 2015

Abstract
Modernity’s grand plans were designed far from where we stand today. The prerogative of progress as an ideological imperative that defined colonialism as a natural balance between the ‘developed’ societies’ moral duty to rescue ‘underdeveloped’ peoples from their fate of myth and superstition created education. Education that functions as an instrument that is used to facilitate the integration of generations into the logic and aesthetics of the status quo and to bring about conformity to the hegemonic cultural form of western technological consumer capitalism. This article explores whose education and for whom was it created by the imperial ideologies, not of nineteenth- or twentieth-century colonialism but for twenty-first-century western technological consumer neo-colonialism. From South Africa’s Apartheid era Liberation before education to Paulo Freire’s practice of freedom, this article questions the practices of new technologies, art and technology education at the edge of the disenfranchised. The traditional frameworks of education are on an ideological and methodological crisis worldwide. The hegemony of knowledge has ruptured away from academia. The linearity of thought has burst open as an omni-directional array. The hierarchy of authorship is contested and the audiences are becoming users and participants. As the ubiquity of information technologies, the emergence of connectedness, cheap chips and the presage of the Internet of things permeates every aspect of a particular section of people clustered in specific cities and spread out around the globe, a unique consciousness is evolving where a new collaboration paradigm is gaining a place of balance between us, nature and our technologies, our positions on social justice, and is evolving a symbiotic outlook at other cultures and societies.
‘Office Exercise’: Towards a more sensible boredom with technology in the office
Authors: Gates Nathan 
Published: February 2015

Abstract
This article is an interrogation of a small practical project I recently undertook to examine the relation between ‘studio exercises’, commonplace in creative practices, and ‘training’ that is typical of corporate environments, to see how this affects the use of technology in each context. This project titled ‘Office Exercise’ focuses on the relationship between the roll of ‘experiment’ and ‘exercise’ in the production of creative work involving technology. As a series of works ‘Office Exercise’ examines creative practice involving technology and the tensions it produces between the artistic applications of technology to a given situation and the simultaneous proficiency/competency of the use of this technology.
This is not an app, this is not an artwork: Exploring mobile selfie-posting software
Authors: Grotepass Maia 
Published: February 2015

Abstract
Creating a mobile software-based exploration (artwork?/app?) puts the artist-coder in a position to interact with the mediated image streams that connect people on the Internet. The mediated streams often contain portraits and self-portraits, selfies, of the participants. These selfies are visual status messages of the people participating in the data streams. They can be used by the poster to identify themselves in the data stream and represent a way the creator of the selfie wants to be seen by the social circle in which the image is posted. These images could reveal recognizable characteristics of the subject. The characteristics could be recognizable by people and software along the mediated path that the image traverses. Algorithmic intervention on the image affects the human and software interpretation of the image. In the works #autoselfie and FIFO ribbon, images are modified on a pixel level, in a way that the user of the app/work cannot control completely. The modifications reveals the potential power of the software systems to modify the imagery that people use to identify themselves in mediated communication environments. Moreover, the changes applied are chosen by the artist coder to impede recognition by software systems downstream but make human recognition possible in some cases. The alterations make the software in the app visible on a pixel level. The works then let the user post the altered images on Twitter or Google+ social media streams. The framing of this work as artwork or mobile app creates a tension, which affects audience interpretation and user experience choices made by the artist. These ideas are explored in the 2013 work #autoselfie and the 2014 work FIFO ribbon that runs on Android devices. #autoselfie was used to remix images created by winners of the South African 2013 Sanlam National Portrait Award, to explore the intervention of algorithms on mediated portraits and self-portraits.