bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anatomical considerations of medial eye wrinkles: Guidelines for botulinum neurotoxin injections
Authors: Yi Kyu‐Ho , Wan Jovian 
Published: July 2024

AbstractCrow's feet lines in the lateral canthal region are a common concern among aging patients, initially appearing as dynamic wrinkles during facial expressions and becoming more pronounced with age. Botulinum neurotoxin temporarily paralyzes muscles by inhibiting acetylcholine release, smoothing wrinkles and enhancing skin's youthful appearance. Effective treatment requires tailored approaches considering individual anatomy and muscle activity. Recent cadaveric studies identified the tear trough muscle, emphasizing its role in infraorbital support and aging. Clinically, patients often present medial eye wrinkles after BoNT treatment for crow's feet, prompting exploration of underlying mechanisms and management strategies. Three cases demonstrated that medial BoNT injections in the orbicularis oculi muscle significantly improve medial eye wrinkles and tear trough appearance. The study underscores the importance of understanding muscle hyperactivity and anatomical variations for precise treatment. Enhanced injection techniques targeting specific areas can achieve better outcomes and minimize complications, particularly in culturally sensitive regions where facial expressions are valued. This research highlights the necessity for comprehensive anatomical knowledge and patient‐specific treatment strategies to address medial eye wrinkles effectively.
Medical assessments for abuse and neglect in contacts of maltreated children
Authors: Kellogg Nancy D. , Lukefahr James L. , Koek Wouter 
Published: July 2024

AimIdentifying abuse or neglect in one child (index) implicates risk to other children residing in the same home (contacts). While child protection investigators may interview and visually examine contacts, there is lack of consensus regarding when contacts should have a medical assessment. Our goal was to describe the prevalence, characteristics and predictors of abuse and neglect among contacts medically assessed by a child maltreatment evaluation centre over a 5‐year period.MethodsRecords of 381 maltreated index children and their 588 contacts were reviewed. Abuse or neglect was diagnosed in 15% of contact children.ResultsWhen index children had more than one type of maltreatment or more than three risk factors, their contacts were more likely to be neglected or abused, respectively. Failure to thrive, patterned injuries, and unmet medical needs were the most common findings among maltreated contacts, and most were diagnosed with injuries or conditions that would not be evident to a child protection investigator.ConclusionsClinicians should consider evaluating contacts of maltreated children who have multiple risk factors or maltreatment types. These evaluations should include a careful assessment for injuries, growth and unmet medical needs.
Effects of Hermetia illucens larvae meal and astaxanthin on intestinal histology and expression of tight junction proteins in weaned piglets
Authors: Szczepanik Kinga , Dobrowolski Piotr , Świątkiewicz Malgorzata 
Published: July 2024

AbstractThe weaning phase in piglets causes significant physiological stress, disrupts intestinal integrity and reduces productivity, necessitating strategies to improve intestinal health and nutrient absorption. While current research highlights the role of diet in mitigating these adverse effects, identifying effective dietary supplements remains a challenge. This study evaluated the effects of Hermetia illucens (HI) larvae meal and astaxanthin (AST) on the intestinal histology of weaned piglets. In a controlled experiment, 48 weaned piglets were divided into six groups and received varying levels of HI larval meal (2.5% and 5%) and AST in their diets. The methodology involved comprehensive histological examinations of the small intestine, assessing absorption area, villi elongation, crypt depth, goblet cells, enterocytes and expression of ileal tight junction (TJ) proteins. The study found that HI larval meal significantly improved nutrient absorption in the jejunum and ileum (p < 0.001), thereby enhancing feed conversion. AST supplementation increased the number of enterocytes (p < 0.001). Both HI larval meal and AST positively affected intestinal morphology and function, increasing muscularis muscle mass and villi elongation (p < 0.001 and p < 0.05, respectively). The 2.5% HI meal improved the villi length to crypt depth ratio and slightly increased the goblet cell count (both p < 0.05). Ki‐67 antibody analysis showed increased cell proliferation in the duodenal and jejunal crypts, particularly with the 2.5% HI meal (p < 0.001). Insect meal did not affect TJ protein expression, indicating that it had no effect on intestinal permeability. These findings suggest that HI larval meal and AST can enhance the intestinal wellness and productivity of weaned piglets.
The photosynthetic performance and photoprotective role of carotenoids response to light stress in intertidal red algae Neoporphyra haitanensis
Authors: Huang Yongbo , Weng Ziyu , Li Shuang , Zhang Shuyu , Chen Haimin , Luo Qijun , Yang Rui , Liu Tao , Wang Tiegan , Zhang Peng , Chen Juanjuan 
Published: July 2024

AbstractNeoporphyra haitanensis, a red alga harvested for food, thrives in the intertidal zone amid dynamic and harsh environments. High irradiance represents a major stressor in this habitat, posing a threat to the alga's photosynthetic apparatus. Interestingly, N. haitanensis has adapted to excessive light despite the absence of a crucial xanthophyll cycle‐dependent photoprotection pathway. Thus, it is valuable to investigate the mechanisms by which N. haitanensis copes with excessive light and to understand the photoprotective roles of carotenoids. Under high light intensities and prolonged irradiation time, N. haitanensis displayed reduction in photosynthetic efficiency and phycobiliproteins levels, as well as different responses in carotenoids. The decreased carotene contents suggested their involvement in the synthesis of xanthophylls, as evidenced by the up‐regulation of lycopene‐β‐cyclase (lcyb) and zeaxanthin epoxidase (zep) genes. Downstream xanthophylls such as lutein, zeaxanthin, and antheraxanthin increased proportionally to light stress, potentially participating in scavenging reactive oxygen species (ROS). When accompanied by the enhanced activity of ascorbate peroxidase (APX), these factors resulted in a reduction in ROS production. The responses of intermediates α‐cryptoxanthin and β‐cryptoxanthin were felt somewhere between carotenes and zeaxanthin/lutein. Furthermore, these changes were ameliorated when the organism was placed in darkness. In summary, down‐regulation of the organism's photosynthetic capacity, coupled with heightened xanthophylls and APX activity, activates photoinhibition quenching (qI) and antioxidant activity, helping N. haitanensis to protect the organism from the damaging effects of excessive light exposure. These findings provide insights into how red algae adapt to intertidal lifestyles.
Serum‐free light chains as a dependable biomarker for stratifying patients with metabolic dysfunction‐associated steatotic liver disease
Authors: Liguori Antonio , D'Ambrosio Francesca , Napodano Cecilia , Gentili Vanessa , Giustiniani Maria Cristina , Pompili Maurizio , Grieco Antonio , Rapaccini Gianludovico , Urbani Andrea , Gasbarrini Antonio , Basile Umberto , Miele Luca ,   FPG‐UCSC PROMETEO Research Group
Published: July 2024

AbstractBackground and AimsAdaptive immunity is gaining a significant role in progression of metabolic dysfunction‐associated steatotic liver disease (MASLD). B‐cell activity can be assessed by serum‐free light chains (sFLCs) k and λ levels. The objective of the present investigation is to examine the utility of sFLCs as non‐invasive biomarkers for the stratification of MASLD.MethodsWe enrolled a consecutive cohort from an outpatient liver unit. Diagnosis of metabolic dysfunction‐associated steatohepatitis (MASH) was made with liver biopsy according to current guidelines. Compensated advanced chronic liver disease (cACLD) and clinically significant portal hypertension (CSPH) were defined according to Baveno VII criteria. sFLCs were measured by turbidimetry using an immunoassay.ResultsWe evaluated 254 patients, 162/254 (63.8%) were male. Median age was 54 years old, and the median body mass index was 28.4 kg/m2. A total of 157/254 (61.8%) subjects underwent liver biopsy: 88 had histological diagnosis of MASH, 89 were considered as simple metabolic dysfunction‐associated steatotic liver (MASL) and 77/254 (30.3%) patients with compensated metabolic dysfunction‐associated cirrhosis. By using Baveno VII criteria, 101/254 (39.7%) patients had cACLD; among them, 45/101 (44.5%) had CSPH. Patients with cACLD showed higher sFLC levels compared with patients without cACLD (p < .01), and patients with CSPH showed higher sFLC levels than patients without CSPH (p < .01). At multivariable analysis, sFLCs were associated with cACLD (p < .05) independently from γ‐globulins and other known dysmetabolic risk factors. κFLC was associated with CSPH (p < .05) independently from γ‐globulins and other known dysmetabolic risk factors.ConclusionsFLCs could be a simple biomarker for stratification of cACLD in MASLD patients.
Intraprofessional cultural competence in nursing regulation: A critical content analysis of standards and codes in the United Kingdom, New Zealand and Australia
Authors: Correa‐Betancour Marcela , Chiarella Mary , Short Stephanie D. 
Published: July 2024

AbstractThere is a global shortage of nurses, leading many countries to recruit internationally qualified nurses (IQNs) to fill the gap. However, IQNs encounter challenges in integrating into their new professional environment, particularly in their interactions with locally qualified nurses (LQNs). Intraprofessional cultural competence (IPCC), defined as ‘a set of congruent behaviours and attitudes that enable professionals to work respectfully and effectively in cross‐cultural situations’, may be a strategy to address these challenges. Content analysis was used to examine nursing regulatory documents (Standards for Practice [Standards] and Codes of Conduct [Codes]) from the United Kingdom, New Zealand and Australia. Data were extracted and organised based on four key themes relevant to IPCC. The analysis revealed a focus on ‘Mutual collaboration and professional relationships’ in six regulatory documents, with explicit commitments to preventing racism and discrimination in the Australian and NZ Codes. However, issues such as racism, discrimination, bullying and harassment faced by IQNs are not comprehensively addressed, as the documents mainly prioritize culturally appropriate patient interactions over relationships between colleagues. Using regulatory documents to address IPCC may influence positive change such as improving communication, and preventing racism, bullying, discrimination and harassment within nursing.
Factors affecting shared decision‐making concerning menopausal hormone therapy
Authors: Koysombat Kanyada , Mukherjee Annice , Nyunt Sandhi , Pedder Hugo , Vinogradova Yana , Burgin Jo , Dave Harshida , Comninos Alexander N. , Talaulikar Vikram , Bailey Julia V. , Dhillo Waljit S. , Abbara Ali 
Published: July 2024

AbstractMenopausal hormone therapy (MHT) is an effective treatment for menopause‐related symptoms. Menopause management guidelines recommend a personalized approach to menopause care, including MHT use. Decision‐making around menopause care is a complex, iterative process influenced by multiple factors framed by perspectives from both women and healthcare providers (HCPs). This narrative review aims to summarize evidence around factors affecting decision‐making regarding menopause‐related care. For HCPs, the provision of individualized risk estimates is challenging in practice given the number of potential benefits and risks to consider, and the complexity of the data available, especially within time‐limited consultations. Women seeking menopause care have the difficult task of making sense of the benefit versus risk profiles to make choices in line with their decisional needs influenced by sociocultural/economic, educational, demographic, and personal characteristics. The press, social media, and influential celebrities also impact the perception of menopause and decision‐making around it. Understanding these factors can lead to improved participation in shared decision‐making, satisfaction with the decision and decision‐making process, adherence to treatment, reduced decisional regret, efficient use of resources, and ultimately long‐term satisfaction with care.
A critical analysis of the effect of OM‐85 for the prevention of recurrent respiratory tract infections or wheezing/asthma from systematic reviews with meta‐analysis
Authors: Castro‐Rodriguez Jose A. , Turi Kedir N. , Forno Erick 
Published: July 2024

AbstractAcute respiratory tract infections (RTIs) are one of the most common causes of pediatric consultations/hospitalizations and a major trigger for asthma exacerbations. Some consensus statements have recommended the use of immunostimulants to boost natural defenses against severe or repeated infections. One of the most common immunostimulants is OM‐85; while several randomized clinical trials (RCTs) have evaluated its efficacy in preventing acute RTIs and wheezing/asthma exacerbations, results have been conflicting. Similarly, various systematic reviews with meta‐analyses (SRMs) on OM‐85 have used different strategies, populations, and outcomes; moreover, SRM conclusions are limited when the original studies are highly heterogeneous or have a low quality, hindering the generalizability of the findings. Here we summarize the evidence on the effect of OM‐85 to prevent acute RTIs, wheezing/asthma episodes, or loss of asthma control in children, by including and critically evaluating all SRMs published to date. We searched for SRMs on OM‐85 in three publication databases and found nine SRMs (seven for RTI, and two for wheezing/asthma). Among those, one had a high confidence evaluation of quality (AMSTAR‐2 tool) and found a reduction in the total number of acute RTIs among the OM‐85 group. Overall, no strong recommendations can be derived from the existing literature, mainly due to the high heterogeneity among included RCTs and SRMs. Further, large, high‐quality RCTs are needed to confirm the true efficacy of OM‐85 for the prevention of acute RTIs, asthma development, and asthma exacerbations.
Evaluating effectiveness of clonal plant selection of alfalfa (Medicago sativa L.) and sainfoin (Onobrychis viciifolia Scop.) in mixtures: Mean performance and stability in a multi‐environment trial
Authors: Bhattarai Surendra , Wang Hu , Poudel Hari P. , Biligetu Bill 
Published: July 2024

AbstractAlfalfa (Medicago sativa L.) ‐ grass or alfalfa ‐ sainfoin (Onobrychis viciifolia Scop.) mixtures are commonly used for pastures in western Canada because of their high forage quality and their low risk of causing frothy bloat in grazing animals. However, the proportion of these two legumes declines in mixed forage stands over time. The objective of this study was to evaluate the effectiveness of selecting superior genotypes from clonally propagated alfalfa or sainfoin under plant competition in different growth environments. For this study, around 100 genotypes of each legume were cloned and transplanted into meadow bromegrass (Bromus riparius Relm.) or alfalfa swards at Saskatoon, SK and Lethbridge, AB, Canada in 2017. Genotype‐environment (G x E) interactions of alfalfa and sainfoin genotypes were analysed by an additive main‐effects and multiplicative interaction (AMMI) model. Significant variations in plant height, spring vigour and total dry matter yield (TDM) were observed for both species. Among the measured traits, plant height was a more highly heritable trait (H2 = .16 for alfalfa and H2 = .18 for sainfoin), while TDM was the least heritable (H2 = .08 for alfalfa and H2 = .04 for sainfoin). In the AMMI Analysis of variance for TDM, the genotype explained <12% of the variation for both species, suggesting a direct selection of yield would result in a low genetic gain. The biplot mean performance (Y) x weighted average of absolute scores from the singular value decomposition of the matrix of BLUPs stability index (WAASB) identified several promising genotypes with superior performance and stability across different environments that were selected for producing synthetic lines. However, the synthetic lines of both alfalfa and sainfoin did not consistently exhibit superior performance in mixtures compared to their respective check cultivars.
Multistress‐tolerant Pseudomonas aeruginosa SSVP3 uses multiple strategies to control Meloidogyne incognita in tomato
Authors: Poria Vikram , Jhilta Prakriti , Adhuna K. P. , Somvanshi Vishal S. , Rana Anuj , Singh Surender 
Published: July 2024

AbstractTomato is the most important horticultural crop, and India is its second largest producer; however, the plant‐pathogenic nematode Meloidogyne incognita is a serious pest of tomato, causing detrimental losses in its production. This study is focused on the use of multistress‐tolerant Pseudomonas aeruginosa SSVP3 to control this devastating nematode and attempts to decipher the roles of its metabolites and volatile organic compounds (VOCs) during this interaction. The supernatant of P. aeruginosa SSVP3 caused 58% mortality in M. incognita J2 juveniles. The major nematicidal metabolites, identified using liquid chromatography‐mass spectrometry, were pyocyanin, pyoluteorin, pyochelin, benthocyanin and phenazines. The VOCs secreted by P. aeruginosa SSVP3, which were identified via gas chromatography–mass spectrometry (HS‐SPME‐GC–MS) in a mixture, caused 98% mortality in M. incognita J2 juveniles. In a pot experiment, seedling root treatment with P. aeruginosa SSVP3 activated the induced systemic response in tomato plants to M. incognita by increasing the activity of defence and antioxidant enzymes as well as the proline and phenolic contents. The malondialdehyde content in P. aeruginosa SSVP3‐treated plants decreased as compared to those in the other treatment groups. The number of galls formed and the number of endoparasitic stages of M. incognita in the untreated nematode control plants were much greater (19 and 35) than those in the P. aeruginosa SSVP3‐treated (0.33 and 1) and chemically treated groups (0.67 and 1.33). These results indicate that P. aeruginosa and its secreted metabolites and VOCs have a high potential for controlling nematodes.
Temporal gamma tACS and auditory stimulation affect verbal memory in healthy adults
Authors: Manippa Valerio , Nitsche Michael A. , Filardi Marco , Vilella Davide , Scianatico Gaetano , Logroscino Giancarlo , Rivolta Davide 
Published: July 2024

AbstractResearch suggests a potential of gamma oscillation entrainment for enhancing memory in Alzheimer's disease and healthy subjects. Gamma entrainment can be accomplished with oscillatory electrical, but also sensory stimulation. However, comparative studies between sensory stimulation and transcranial alternating current stimulation (tACS) effects on memory processes are lacking. This study examined the effects of rhythmic gamma auditory stimulation (rAS) and temporal gamma‐tACS on verbal long‐term memory (LTM) and working memory (WM) in 74 healthy individuals. Participants were assigned to two groups according to the stimulation techniques (rAS or tACS). Memory was assessed in three experimental blocks, in which each participant was administered with control, 40, and 60 Hz stimulation in counterbalanced order. All interventions were well‐tolerated, and participants reported mostly comparable side effects between real stimulation (40 and 60 Hz) and the control condition. LTM immediate and delayed recall remained unaffected by stimulations, while immediate recall intrusions decreased during 60 Hz stimulation. Notably, 40 Hz interventions improved WM compared to control stimulations. These results highlight the potential of 60 and 40 Hz temporal cortex stimulation for reducing immediate LTM recall intrusions and improving WM performance, respectively, probably due to the entrainment of specific gamma oscillations in the auditory cortex. The results also shed light on the comparative effects of these neuromodulation tools on memory functions, and their potential applications for cognitive enhancement and in clinical trials.
Publishing experiences of researchers in the developing world: An analysis of submissions to the Review of Development Economics, January 2015 to April 2022
Authors: McKay Andy 
Published: July 2024

AbstractResearchers based in poorer countries typically face major challenges in publishing their work in international journals, compared to those faced by researchers in the wealthier countries of Europe and North America. This paper studies this issue based on the experience of papers submitted to the Review of Development Economics, an important international development economics journal. It presents an analysis of submissions and success in publication, based on the fortunes of all papers submitted to the journal between 2015 and April 2022, disaggregated by the country in which the corresponding author is based. Authors based in low and middle income countries accounted for 33% of publications in this period, though they accounted for 61% of the submissions received. A main factor was that these papers were significantly less likely to be sent for review by the journal; if reviewed, they were also less likely to be accepted than papers from authors in high income countries, though that differential is much less stark. This analysis is presented in the interests of transparency and to encourage discussion, but also to raise issues the journal needs to address. The paper finishes by reviewing, based on co‐editor experience over this period, issues and potential responses.
Bottom Copy Pronunciation in Japanese Passives
Authors: Abe Jun 
Published: July 2024

AbstractOn the basis of Abe's (2016) proposal that in the case of an A‐chain, any member can be the target for pronunciation, I argue that Japanese passives may have the bottom copies of the produced A‐chains pronounced. When the passivized subjects appear to occupy their original θ‐positions, it is standardly claimed that the relevant word order is derived by scrambling other material sentence‐initially. Contrary to this claim, I demonstrate that there are cases, including those of what Miyagawa (1989) calls the causative‐passive construction, where the passivized subjects actually occupy their original θ‐positions. I then provide evidence that those passivized subjects undergo “covert” A‐movement, hence giving support to my bottom copy pronunciation analysis.
Computed tomographic and magnetic resonance imaging features of canine cervical epidural dirofilariasis
Authors: Lim Sohee , You MyungJo , Sohn Sangjune , Won Sungjun , Song Donghyon , Hong Yeonjung 
Published: July 2024

AbstractAn 8‐year‐old neutered male Maltese dog presented with a month‐long history of progressive nonambulatory tetraparesis. MRI revealed a well‐defined, centrally nonenhanced, T1‐weighted hypointense, extradural structure located in the vertebral canal at the level of the C5 vertebral body. CT demonstrated a hypoattenuating, space‐occupying structure in the same area. Surgery revealed a long, narrow parasite in the epidural space. An adult Dirofilaria immitis was confirmed by multiplex polymerase chain reaction (PCR) assay. This is a novel report describing the MRI and CT features of cervical epidural dirofilariasis in a dog.