bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expanding foresight practitioner excellence: Assessment of practitioner evaluation capacity
Authors: Tonn Bruce , Gardner Annette L. , Lesieur Bill 
Published: July 2024

AbstractForesight evaluation is an emerging area of evaluation practice. In 2021, the Association of Professional Futurists (APF) conducted a survey of foresight practitioners to assess their capacity to conduct quality evaluation. Results suggest a moderate level of evaluation capacity exists amongst the APF membership, though the use of evaluation is low overall. Respondents with evaluation experience report being able to do both process and impact evaluations. Additionally, foresight practitioners understand the importance of evaluation, particularly to improve their foresight practice, and use evaluation findings for multiple reasons. However, respondents indicate the barriers to the evaluation of foresight are numerous. One group of factors is related to a lack of knowledge about evaluation and how to collect and analyze data related to the evaluation of foresight. Other barriers were attributed to the perceived lack of appreciation of the value of evaluation of foresight by clients and funders. Lastly, study findings speak to the need for a multifaceted approach with diverse resources to strengthen individual and organizational foresight evaluation capacity.
Antimicrobial Potential of Brassica oleracea Extracts (White and Broccoli) and Their Resistance Compared to Doxycycline Against Gram‐Positive and Gram‐Negative Bacteria
Authors: Rahmani Meisam , Esmaeili Akbar , Taherkhani Mahboubeh 
Published: July 2024

AbstractBrassica oleracea L is low in carbohydrates and fiber, making it ideal for low‐carb diets. But they are rich in vitamins, minerals, and other essential nutrients. The present article investigated the antimicrobial effect of B. oleracea extract (white and broccoli) (BOE‐WB) on Gram‐positive and Gram‐negative strains and its resistance to doxycycline. BOE‐WB was used as the soaking method. It was analyzed by gas chromatography–mass spectroscopy (GC–MS), high‐performance liquid chromatography (HPLC), and 2,2‐Diphenyl‐1‐picrylhydrazyl (DPPH) methods. The samples were prepared with three concentrations. It used Mueller Hinton Agar culture medium of fresh bacteria. It was incubated for 24 h in a 37°C incubator. It identified 33 compounds. For BOE‐W, 77% of the compounds are oxygenated, while for BOE‐B, this percentage is 79%. For BOE‐B, 79% had oxygenated compounds. BOE‐WB has significant antibacterial effects on Pseudomonas aerogenosa and Bacillus cereus. The lethal impact of BOE‐WB on strains is very close to that of doxycycline, and it can be introduced as a new antimicrobial drug to the medical world. The research shows that the percentage of oxygenated compounds in foods containing BOE‐B is much higher than that of BOE‐W. It has a significant impact on the antioxidant effect. Foods containing BOE‐W have a high percentage of azo compounds and sulfur. One of the benefits of sulfur in the body is disinfecting the blood. In addition, sulfur increases the body's resistance to bacteria.
Identification of meat adulteration in minced meat samples labeled as beef and mutton in Tehran stores using duplex PCR
Authors: Doroudian Mohammad , Soezi Mahdieh , Rasouli Milad , Arshadi Far Maryam , Yousefi Dehbidi Maryam , Maafi Pedram , Yousefi Forough , Ajouri Mohammad‐Reza , Omidi Bijan 
Published: July 2024

AbstractFood fraud and profiteering are becoming increasingly common in the meat industry. Therefore, it is essential to identify such practices to prevent consumer deception and maintain food safety. This study aimed to determine the contents of minced meat samples labeled as beef and mutton in retail stores across Tehran province, Iran, to identify instances of meat adulteration. To this end, this study randomly collected 300 minced meat samples labeled as beef and mutton from Tehran stores over 4 years (2018–2022) and analyzed them using duplex polymerase chain reaction (PCR). The results revealed that more than 95% of the samples only contained beef, while only 5% of the samples matched the label and contained a mixture of beef and mutton. This discrepancy between the label and actual contents could be attributed to the price difference between beef and mutton, providing a financial incentive for producers to maximize profits. Given the potential for meat adulteration, increased monitoring of meat products is necessary, including detailed tests such as PCR, which is a fast, easy, sensitive, specific, and highly effective method for detecting meat adulteration. The findings of this study can assist in developing effective strategies to prevent meat adulteration and maintain consumer confidence in the meat industry.
A provenance investigation on Middle–Upper Paleolithic chipped chert tools from North Bosnia
Authors: Petros Chatzimpaloglou , Tonko Rajkovača , Ivana Pandžić 
Published: July 2024

AbstractThis study presents the results of a provenance study on Middle–Upper Paleolithic chert tools from North Bosnia. It is part of a larger geoarchaeological research dedicated to using interdisciplinary methodologies to collate and review the known Middle–Upper Paleolithic archaeological record of North Bosnia. Chert is a raw material commonly used in prehistory for tool crafting and this region is known to have abundant geological sources. However, there is a lack of detailed data, especially regarding the geochemical characteristics and composition of these sources. The Middle‐Upper Paleolithic lithic assemblages found in North Bosnia are dominated by chert and there is an untested theory suggesting the exploitation of local sources. The presented research uses macroscopic examination and laser ablation‐inductively coupled plasma mass spectrometry to distinguish the different chert varieties and identify groups with specific geochemical characteristics/signatures in the assemblages. The field‐ and lab‐based work suggests multiple sources but most importantly, presents strong evidence of chert tools having almost identical geochemical signatures with specific chert sources from North Bosnia. These are the first results confirming the exploitation of Indigenous chert sources and subsequently providing insights into hominan activity and raw‐material networks during the Middle–Upper Paleolithic in the region.
Impact of second autologous stem‐cell transplantation at relapsed multiple myeloma: A French multicentric real‐life study
Authors: André Axel , Montes Lydia , Roos‐Weil Damien , Frenzel Laurent , Vignon Marguerite , Chalopin Thomas , Debureaux Pierre‐Edouard , Talbot Alexis , Farge Agathe , Jardin Fabrice , Belhadj Karim , Royer Bruno , Marolleau Jean‐Pierre , Arnulf Bertrand , Morel Pierre , Harel Stéphanie 
Published: July 2024

AbstractA second autologous stem‐cell transplantation (ASCT2) is considered for relapsed multiple myeloma (RMM) patients showing prolonged response after a first ASCT. However, given breakthrough treatments like anti‐CD38 and immunotherapy, its role remains debated. We conducted a real‐life study in 10 French centers (1996–2017) involving 267 RMM patients receiving ASCT2. The median age was 61 years, with 49% females. Most patients received melphalan 200 mg/m² before ASCT2, with low early mortality (1%). Very good partial response or better (VGPR+) rate post ASCT2 was 78%. Post ASCT2, 48% received consolidation therapy and 40% maintenance therapy. Median event‐free survival (EFS) after ASCT2 was 2.6 years (95% confidence interval [CI]: 2.3–2.8), and 2‐year EFS estimate was 63% (95% CI: 57–70). Median overall survival (OS) was 8.1 years (95% CI: 5.9–NA), and 2‐year OS estimate was 92% (95% CI: 88–95). Multivariate analysis revealed that VGPR+ status and maintenance therapy post ASCT2 were associated with better EFS (hazard ratio [HR]: 0.6; 95% CI: 0.3–0.9, p = 0.012 and HR: 0.4; 95% CI: 0.3–0.6, p < 0.001, respectively) and OS (HR: 0.4; 95% CI: 0.2–0.9, p = 0.017 and HR: 0.2; 95% CI: 0.1–0.4, p < 0.001, respectively), while male sex correlated with poorer outcomes for EFS (HR: 2.5; 95% CI: 1.7–3.7, p < 0.001) and OS (HR: 2.7; 95% CI: 1.4–4.9, p = 0.002). Overall, ASCT2 appeared efficient with low toxicity in RMM. Maintenance therapy was associated with extended EFS and OS, particularly in patients with VGPR+ status post ASCT2. These findings underscore ASCT2's potential in RMM when coupled with maintenance therapy in selected patients.
Factors associated with patients' experience of access to their multidisciplinary primary health care clinic: A multilevel analysis
Authors: Breton Mylaine , Gaboury Isabelle , Lamoureux‐Lamarche Catherine , Deslauriers Véronique , Beaulieu Christine , Martin Élisabeth , Berbiche Djamal 
Published: July 2024

AbstractBackgroundUnderstanding patients' experiences accessing primary health care (PHC) is necessary to improve service organisation. This study aims to examine individual, organisational, and contextual factors associated with patients' experience of accessing the multidisciplinary PHC clinic to which they are attached.MethodsThis cross‐sectional study builds on survey data collected in multidisciplinary PHC clinics located in 14 regions in the province of Quebec (Canada). Between September 2022 and June 2023, an online questionnaire was sent to patients with an email contact and attached to a family physician. Two patient‐reported experience measures were assessed: (1) difficulty obtaining an appointment with their regular family physician or nurse practitioner and (2) perceived unmet healthcare needs. A self‐reported online questionnaire based on the advanced access model was also sent to PHC professionals and administrative staff to assess the use of advanced access strategies in their practice. Multilevel logistic regression models were fit. Stratified analyses were conducted according to the number of consultations received.FindingsIn total, 122,397 patients and 847 family physicians, 97 nurse practitioners and 347 administrative staff nested into 104 clinics answered the survey. In the overall sample, having a chronic disorder was the only individual factor associated with the patient experience of access. Organizational factors including estimation of demand and supply, use of a referral algorithm, and strategies to optimise consultations were associated with a better access experience. Patients from medium size clinics compared to small clinics had better experiences of care for both outcomes. Stratified analysis indicated similar results for patients who consulted at the clinic 1–5 times in the last 12 months as observed in the overall sample.ConclusionsThis study indicates that enhancing organizational processes can improve patients' access experiences.
Interactions between toll‐like receptors signaling pathway and gut microbiota in host homeostasis
Authors: Chen Luping , Zhang Linfang , Hua Hua , Liu Li , Mao Yuejian , Wang Ruirui 
Published: July 2024

AbstractBackgroundToll‐like receptors (TLRs) are a family of fundamental pattern recognition receptors in the innate immune system, constituting the first line of defense against endogenous and exogenous antigens. The gut microbiota, a collection of commensal microorganisms in the intestine, is a major source of exogenous antigens. The components and metabolites of the gut microbiota interact with specific TLRs to contribute to whole‐body immune and metabolic homeostasis.ObjectiveThis review aims to summarize the interaction between the gut microbiota and TLR signaling pathways and to enumerate the role of microbiota dysbiosis‐induced TLR signaling pathways in obesity, inflammatory bowel disease (IBD), and colorectal cancer (CRC).ResultsThrough the recognition of TLRs, the microbiota facilitates the development of both the innate and adaptive immune systems, while the immune system monitors dynamic changes in the commensal bacteria to maintain the balance of the host‐microorganism symbiosis. Dysbiosis of the gut microbiota can induce a cascade of inflammatory and metabolic responses mediated by TLR signaling pathways, potentially resulting in various metabolic and inflammatory diseases.ConclusionUnderstanding the crosstalk between TLRs and the gut microbiota contributes to potential therapeutic applications in related diseases, offering new avenues for treatment strategies in conditions like obesity, IBD, and CRC.
Profile of female survivors of sexual violence in the first 6 months of the COVID‐19 quarantine in the city of Campinas, Brazil: A cross‐sectional retrospective study
Authors: Côrtes Maria Teresa Ferreira , Alves Ândria Cléia , Teixeira Ana Luiza , Alabarse Otávio Prado , dos Santos Júnior Amilton , dos Santos Fernandes Arlete Maria , de Azevedo Renata Cruz Soares 
Published: July 2024

AbstractObjectivesDescribe the characteristics and changes in the profile of women who sought care after experiencing sexual violence (SV) during the first six months of the COVID‐19 pandemic in a Brazilian city.MethodsThis is a cross‐sectional retrospective study. Data from emergency care and legal abortion requests of women assisted at the Women's Health Care Center Hospital (School of Medical Sciences, University of Campinas, Brazil) due to SV experienced between March 23 and August 23, 2020 (Quarantine Group, QG), were collected and compared with data from the same period of the previous biennium (Comparison Group, CG). χ2 and Fisher's exact tests were used to compare groups; the significance level was 5%.ResultsData for 236 women were analyzed; 70 women were included in the QG and 166 in the CG. In the QG, there was a restriction in the area of origin of women, with a higher proportion of women who lived in Campinas (P = 0.0007) and a higher frequency of chronic SV (P = 0,035). There were no rapes associated with the use of social media or apps in the QG, but 9.8% of women in the CG experienced rape associated with the use of social media or apps. There were higher rates of domestic violence (P = 0.022) and intimidation through physical force (P = 0.011) in the first two months.ConclusionThe COVID‐19 quarantine affected the profile of women who sought care after experiencing SV. The quarantine resulted in changes in the area of origin of patients, hindering access to health services and leading to higher rates of chronic and domestic SV, particularly in the first 2 months of the pandemic.
Semantic sensor data integration for talent development via hybrid multi‐objective evolutionary algorithm
Authors: Luo Fang , Yang Ya‐Juan , Geng Yu‐Cheng 
Published: July 2024

AbstractIn this work, we propose a new hybrid Multi‐Objective Evolutionary Algorithm (hMOEA) specifically designed for semantic sensor data integration, targeting talent development within the burgeoning field of the Semantic Internet of Things (SIoT). Our approach synergizes the capabilities of Multi‐Objective Particle Swarm Optimization and Genetic Algorithms to tackle the sophisticated challenges inherent in Sensor Ontology Matching (SOM). This innovative hMOEA framework is adapt at discerning precise semantic correlations among diverse ontologies, thereby facilitating seamless interoperability and enhancing the functionality of IoT applications. Central to our contributions are the development of an advanced multi‐objective optimization model that underpins the SOM process, the implementation of the hMOEA framework which sets a new benchmark for accurate semantic sensor data integration, and the rigorous validation of hMOEA's superiority through extensive testing in varied real‐world SOM scenarios. This research not only marks a significant advancement in SOM but also highlights the critical role of cutting‐edge SOM methodologies in educational curricula, for example, the new business subject education proposed by China in recent years, aimed at equipping future professionals with the necessary skills to innovate and lead in the SIoT and SW domains.
Paternal and maternal psychological distress and adolescent health risk behaviors: The role of sensitive periods
Authors: Sifaki Maria , Flouri Eirini , Midouhas Emily 
Published: July 2024

AbstractIntroductionAdolescent health risk behaviors are linked to poor physical and mental health outcomes. While past research shows that maternal psychological distress predicts those behaviors, we know less about the role of paternal psychological distress and the role of sensitive periods.MethodsUsing 11,128 data from families (50.5% female children) from the UK's Millennium Cohort Study, we examined the role of timing of exposure to paternal and maternal psychological distress in engagement in health risk behaviors (smoking, alcohol use, binge drinking, and sexual activity) at age 14. Paternal and maternal psychological distress, measured with the Kessler‐6 scale, were assessed at child ages 3, 7, and 11. We performed path analysis, adjusting for key covariates, modeling maternal distress parallel to paternal, and allowing for autoregressive paths.ResultsPaternal distress experienced at age 11 predicted a higher likelihood of smoking at age 14. Maternal distress at age 7 also predicted a higher likelihood of smoking, alcohol use, and binge drinking, but only for boys. Moreover, maternal distress at age 3 was associated with a lower risk for alcohol use. Effects were not replicated in the sensitivity analysis we performed, including only families with resident biological fathers across the study period. Instead, maternal and paternal distress at age 11 raised girls' risk for binge drinking and sexual activity, respectively.ConclusionsParental distress in early childhood does not predict adolescent health risk behaviors. In late childhood, however, both paternal and maternal distress seem to influence the likelihood of engagement in such behaviors.
Can flowable short‐fiber‐reinforced resins achieve a strong adhesion to bioceramics?
Authors: Topbaş Celalettin , Kul Abdurrahman Kerim 
Published: July 2024

AbstractThis study compared the microshear bond strength (μSBS) of four calcium silicate‐based cements (CSCs), TheraCal PT (TPT), TheraCal LC (TLC), Biodentine (BD), and Dia‐Root Bio MTA (DR), with a short fiber‐reinforced composite resin (SFRC). Forty cylindrical acrylic blocks were used, each with a center hole (diameter 5 mm, depth 2 mm). CSCs were placed in the holes (n = 10/group), and the blocks were incubated for 48 h. G‐Premio BOND, a self‐etching adhesive, was applied to the CSCs surfaces using a micro‐applicator for 10 s and then air‐dried for 5 s, followed by light curing for 20 s. SFRC materials placed in cylindrical polyethylene capsules (diameter 2 mm, height 2 mm) were polymerized for 20 s and placed over the CSCs. The samples were then incubated at 37°C and 100% humidity for 24 h, and their μSBSs were tested using an “Instron Universal Testing Machine.” Data were statistically analyzed using chi‐square and Kruskal–Wallis tests. Statistically significant differences were observed between the tested CSCs. The μSBS of TPT (45.17 ± 4.56 MPa) was significantly higher (p < .05) than that of the other materials: BD, TLC, and DR had μSBSs of 29.18 ± 2.86 MPa (p < .05), 23.86 ± 2.84 MPa (p > .05), and 18.08 ± 2.69 MPa (p < .05), respectively. Considering the importance of bond strength for CSC sealing with restorative material, using SFRC over CSC was promising for improving the μSBS, adhesion, and sealing of the material.Research Highlights
Adhesion is critical to the success of vital pulp restorations.
To achieve strong adhesion, the bioceramic material and the resin composite to which it is bonded are very important.
In our study, short fiber‐reinforced composite resin, which is gaining popularity, was used and found to be a promising material for improved adhesion.
Blood and urine biomarkers for the diagnosis of early stages of knee osteoarthritis: A systematic review
Authors: Ostojic Marko , Oliveira Joao Pedro , Kordic David , Mouton Caroline , Prill Robert , Becker Roland 
Published: July 2024

AbstractPurposeTo identify biomarkers in human blood or urine at an early stage of knee osteoarthritis (OA) and to elucidate if any can accurately differentiate between healthy controls and early knee OA patients and be considered as a candidate for widespread clinical use for early diagnosis of the disease.MethodsMedline, Embase and Web of Science were screened to identify comparative studies measuring differences in blood or urine biomarkers between healthy controls and knee OA patients at an early stage (grade 1 or 2 Kellgren–Laurence). Two independent reviewers screened the abstracts for eligibility, reviewed the full texts, assessed the methodological quality and extracted the data. The Joanna Briggs Institute critical appraisal tool for diagnostic test accuracy studies was used to assess the quality of the included studies. Due to relevant heterogeneity, meta‐analysis was not appropriate.ResultsFive studies met the eligibility criteria. The examined biomarkers were adropin, collagen type II metabolite, C‐terminal cross‐linked telopeptide of type II collagen, C‐terminal cross‐linked telopeptide of type I collagen, cartilage oligomeric matrix protein, matrix metalloproteinase 3, N‐terminal propeptide of procollagen type IIA, type I procollagen N‐terminal propeptides, N‐terminal osteocalcin, angiopoietin‐2, follistatin, granulocyte colony‐stimulating factor, hepatocyte growth factor, interleukin‐8, leptin, platelet‐derived growth factor‐BB, platelet endothelial cell adhesion molecule‐1, vascular endothelial growth factor and calprotectin and totalling 19 biomarkers. All of the biomarkers were studied only once in the selected papers.ConclusionsThere is no reliable biomarker available to differentiate between early knee OA in patients and healthy controls, but a potential role of a cluster of biomarkers to close this gap. There are several limitations, including inappropriate study designs, small sample sizes, nonconsecutive patient groups and inadequate statistical methods for evaluating biomarker performance in studies included.Level of EvidenceLevel III.
Positive association between patient experience of primary care with chronic disease and self‐rated health in a Japanese rural area: A cross‐sectional questionnaire survey using the Japanese primary care assessment tool short form
Authors: Nishida Sakiya , Hisata Yoshio , Yasaka Aki , Sugioka Takashi , Hirata Risa , Katsuki Naoko E. , Tago Masaki , Ueda Yuki , Amenomori Masaki , Higashino Katsumi , Naya Yoshio 
Published: July 2024

AbstractBackgroundLow birthrates and an aging society during population decline have brought about labor shortages and increased medical care needs. Medical resources should be distributed appropriately, particularly in rural areas. High‐quality primary care can make the medical system more effective and contribute to rural residents' health. However, there are no reports on the impact of primary care on health in the rural areas of Japan. This study examined the effect of primary care quality on self‐rated health in a rural Japanese area.MethodsWe conducted a cross‐sectional study using a questionnaire survey of residents of a rural area in northern Shiga Prefecture in 2021. Self‐rated health (SRH) was used as the health outcome (1–5 points), and the Japanese Primary Care Assessment Tool Short Form (JPCAT‐SF) was used to measure the patients' experience of primary care (0–100 points). We conducted a multivariate analysis using logistic regression analysis and examined the association between good SRH (4 points or more) and high JPCAT‐SF scores (above average score), adjusted for sociodemographic confounding factors.ResultsA total of 1108 men and 1412 women responded to the survey. The mean patient age was 69.8 years. The mean JPCAT‐SF score was 51.8 points. Among the 1172 patients with chronic diseases, good SRH was associated with high JPCAT‐SF scores (odds ratio [OR] 1.32, 95% confidence interval [CI] 1.009–1.73).ConclusionsGood SRH among rural residents with chronic disease was associated with high primary care quality.