bluuebunny/crossref_metadata_2025_split huggingface dataset:
BMI z-score as a prognostic factor for height velocity in children treated with recombinant human growth hormone due to idiopathic growth hormone deficiency
Authors: Budzulak Joanna , Majewska Katarzyna Anna , Kędzia Andrzej 
Published: August 2024

Abstract
Purpose
Growth hormone deficiency (GHD) causes growth disturbances during childhood. The most recommended treatment of GHD is the administration of recombinant human growth hormone (rhGH). Recent studies have proved that well-nourished GHD children respond better to rhGH therapy compared to undernourished individuals. The aim of this study was to analyze nutritional status along with height velocity in GHD children during the first two years of rhGH therapy, and to estimate the optimal BMI z-score range in which these children achieve the best growth results.

Methods
This retrospective analysis included 80 prepubertal idiopathic GHD children treated with rhGH. Anthropometric data were obtained from medical records made at an initial visit and then follow-up visits after 12 and 24 months of treatment. The body mass index (BMI) was calculated and standardized into z-score, basing on Cole’s LMS method. Then, the BMI z-score was analyzed in relation to the parameters of growth response.

Results
The higher the BMI z-score at treatment entry, the greater the increase in height during the first twelve months of rhGH therapy. BMI z-score ≥0 noted at the beginning of each year of the treatment are associated with significantly better growth increments throughout the first and the second years of the therapy.

Conclusion
Prepubertal idiopathic GHD children with BMI z-score below 0 would probably benefit from the improvement of their nutritional status prior to the rhGH treatment beginning. It seems that increasing BMI z-score to obtain values between 0 and 1 would be optimal for the growth process.
A Complex Interplay Between Melatonin and RORβ: RORβ is Unlikely a Putative Receptor for Melatonin as Revealed by Biophysical Assays
Authors: Panmanee Jiraporn , Charoensutthivarakul Sitthivut , Cheng Chew Weng , Promthep Kornkanok , Mukda Sujira , Prasertporn Tanya , Nopparat Chutikorn , Teerapo Kittitat , Supcharoen Promsup , Petchyam Nopphon , Chetsawang Banthit , Govitrapong Piyarat , Phanchana Matthew 
Published: August 2024

Abstract
A nuclear retinoic acid receptor (RAR)-related orphan receptor β (RORβ) is strictly expressed in the brain, particularly in the pineal gland where melatonin is primarily synthesized and concentrated. The controversial issues regarding the direct interaction of melatonin toward ROR receptors have prompted us to investigate the potential melatonin binding sites on different ROR isoforms. We adopted computational and biophysical approaches to investigate the potential of melatonin as the ligand for RORs, in particular RORβ. Herein, possible melatonin binding sites were predicted by molecular docking on human RORs. The results showed that melatonin might be able to bind within the ligand-binding domain (LBD) of all RORs, despite their difference in sequence homology. The predicted melatonin binding scores were comparable to binding energies with respect to those of melatonin interaction to the well-characterized membrane receptors, MT1 and MT2. Although the computational analyses suggested the binding potential of melatonin to the LBD of RORβ, biophysical validation failed to confirm the binding. Melatonin was unable to alter the stability of human RORβ as shown by the unaltered melting temperatures upon melatonin administration in differential scanning fluorometry (DSF). A thermodynamic isothermal titration calorimetry (ITC) profile showed that melatonin did not interact with human RORβ in solutions, even in the presence of SRC-1 co-activator peptide. Although the direct interaction between the LBD of RORβ could not be established, RORα and RORβ gene expressions were increased upon 24 h treatment with μM-range melatonin. Our data, thus, support the studies that the nuclear effects of melatonin may not be directly mediated via its interaction with the RORβ. These findings warrant further investigation on how melatonin interacts with ROR signaling and urge the melatonin research community for a paradigm shift in the direct interaction of melatonin toward RORs. The quest to identify nuclear receptors for melatonin in neuronal cells remains valid for the community to achieve.
Can Agricultural Managed Aquifer Recharge (Ag‐MAR) Recover Return Flows Under Prior Appropriation in a Warming Climate?
Authors: Morrisett Christina N. , Van Kirk Robert W. , Null Sarah E. 
Published: August 2024

AbstractGroundwater return flow to streams is important for maintaining aquatic habitat and providing water to downstream users, particularly in irrigated watersheds experiencing water scarcity. However, in many agricultural regions, increased irrigation efficiency has reduced return flows and their subsequent in‐stream benefits. Agricultural managed aquifer recharge (Ag‐MAR)—where artificial recharge is conducted via irrigation canals and agricultural fields—may be a tool to recover these return flows, but implementation is challenged by water supply and water management. Using climate‐driven streamflow simulations, an integrated operations‐hydrology model, and a regional groundwater model, we investigated the potential for Ag‐MAR to recover return flows in the Henrys Fork Snake River, Idaho (USA). We simulated potential Ag‐MAR operations for water years 2023–2052, accounting for both future water supply conditions and local water management rules. We determined that Ag‐MAR operations reduced springtime peak flow at the watershed outlet by 10%–14% after accounting for return flows. Recharge contribution to streamflow peaked in July and November, increasing July–August streamflow by 6%–14% and November–March streamflow by 9%–14%. Furthermore, sites where Ag‐MAR was conducted incidental to flood irrigation had more water available for recharge, compared to sites requiring recharge rights, which are junior in priority to agricultural rights. Mean annual recharge volume for the incidental recharge sites averaged 12% of annual natural streamflow, ranged from 269 to 335 Mm3, and was largely available in April and October. We demonstrate Ag‐MAR can effectively recover groundwater return flows when applied as flood irrigation on agricultural land with senior‐priority water rights.
Mapping Pressure Surge Source in Urban Water Networks: Integrating Low‐ and High‐Frequency Pressure Data With an Illustrative Real Case Study
Authors: Meniconi S. , Rubin A. , Tirello L. , Doro A. , Brunone B. , Capponi C. 
Published: August 2024

AbstractThis paper introduces a novel methodology that integrates low‐ and high‐frequency pressure monitoring in the parts of the urban water distribution network characterized by the largest number of repairing operations. This integrated approach aims to pinpoint the source and characterize potentially dangerous pressure variations. The actual behavior of a real operational water distribution network is considered as an example to verify the effectiveness of the proposed methodology. The analysis of the acquired pressure signals allows for mapping frequent pressure surges and identifying their source in the functioning conditions of a big user. Notwithstanding these pressure variations are not overly large, according to the literature, their near‐continuous nature poses a risk of inducing pipe breaks, and then leakage, due to fatigue. The proposed method integrating routine low‐frequency measurements with targeted high‐frequency surveys provides a cost‐effective, proactive management strategy.
Spatiotemporal Characteristics and Physical Drivers of Heatwaves in India
Authors: Dar Javid Ahmad , Apurv Tushar 
Published: August 2024

AbstractIn this study, we analyze the spatiotemporal patterns of propagation of pre‐monsoon heatwaves and their drivers in India. Using complex networks, we find that heatwaves originate most frequently in northwest India and propagate in the northeast or southeast direction. Heatwaves propagating in the northeast direction have a higher intensity, lower moving distance, smaller areal coverage, and shorter duration than heatwaves moving in the southeast. We find that the larger area and duration of heatwaves propagating southeast are a result of development of larger and more persistent high‐pressure systems extending over entire northern and eastern India, which are influenced by El Niño Southern Oscillation. On the other hand, higher radiative fluxes and larger heat entrainment in the boundary layer in the heatwaves propagating northeast contribute to their higher intensities.
Ice Sheet‐Albedo Feedback Estimated From Most Recent Deglaciation
Authors: Booth Alice , Goodwin Philip , Cael B. B. 
Published: August 2024

AbstractIce sheet feedbacks are underrepresented in model assessments of climate sensitivity and their magnitudes are still poorly constrained. We combine a recently published record of Earth's Energy Imbalance (EEI) with existing reconstructions of temperature, atmospheric composition, and sea level to estimate both the magnitude and timescale of the ice sheet‐albedo feedback since the Last Glacial Maximum. This facilitates the first opportunity to quantify this feedback over the most recent deglaciation using a proxy data‐driven approach. We find the ice sheet‐albedo feedback to be amplifying, increasing the total climate feedback parameter by 42% and reaching an equilibrium magnitude of 0.55 Wm−2K−1, with a 66% confidence interval of 0.45–0.63 Wm−2K−1. The timescale to equilibrium is estimated as 3.6 ka (66% confidence: 1.9–5.5 ka). These results provide new evidence for the timescale and magnitude of the amplifying ice sheet‐albedo feedback that will drive anthropogenic warming for millennia to come.
Statistical Investigation of the Storm Time Plasma Density Strip‐Like Bulges at Lower‐Mid Latitudes
Authors: Du Wenyu , Zhong Jiahao , Wan Xin , Hao Yongqiang , Xiong Chao , Wang Hui , Cui Jun , Liu Yiwen , Li Qiaoling , Kuai Jiawei 
Published: August 2024

AbstractThe strip‐like bulge is a storm‐time conjugate ionospheric plasma density enhancement, constituted by the plasmaspheric H+/He+, that extends widely (over 150° in longitude) in the zonal dimension but occupies only 1°–5° in latitude. Based on in‐situ measurements of 11 low earth orbit satellites, this study statistically investigates the bulge structures of geomagnetic storms driven by 136 interplanetary coronal mass ejections during 2000–2021. The statistical results show that the strip‐like bulges are observed at the end of the storm main phase and can persist for more than 60 hr. The spatial and temporal coverage of the strip‐like bulge varies from storm to storm. However, the bulges do exhibit occurrence preferences: stronger storms (for the ICME‐driven) during solar minimum periods, the Asian‐Pacific sector (with eastward magnetic declination), and the nightside of the dawn‐dusk terminator. A quiet time density enhancement called mid‐latitude enhancement could be recognized as a precursor of the strip‐like bulge. The evolution features of the plasmapause height exhibit similarities with the strip‐like bulge, indicating a field‐aligned downward and cross‐L inward intrusion of the plasmaspheric ions. The local net ion drifts partly support this scenario with downward/inward being the most dominant but not unique pattern, the other diverse net ion drift configurations exist but their impact on the strip‐like bulges remains unclear.
Mesosphere and Lower Thermosphere Wind Perturbations Due To the 2022 Hunga Tonga‐Hunga Ha'apai Eruption as Observed by Multistatic Specular Meteor Radars
Authors: Chau Jorge L. , Poblet Facundo L. , Liu Hanli , Liu Alan , Gulbrandsen Njål , Jacobi Christoph , Rodriguez Rodolfo R. , Scipion Danny , Tsutsumi Masaki 
Published: August 2024

AbstractUtilizing multistatic specular meteor radar (MSMR) observations, this study delves into global aspects of wind perturbations in the mesosphere and lower thermosphere (MLT) from the unprecedented 2022 eruption of the Hunga Tonga‐Hunga Ha'apai (HTHH) submarine volcano. The combination of MSMR observations from different viewing angles over South America and Europe, and the decomposition of the horizontal wind in components along and transversal to the HTHH eruption's epicenter direction allow an unambiguous detection and identification of MLT perturbations related to the eruption. The performance of this decomposition is evaluated using Whole Atmosphere Community Climate Model with thermosphere/ionosphere extension (WACCM‐X) simulations of the event. The approach shows that indeed the HTHH eruption signals are clearly identified, and other signals can be easily discarded. The winds in this decomposition display dominant Eastward soliton‐like perturbations observed as far as 25,000 km from HTHH, and propagating at 242 m/s. A weaker perturbation observed only over Europe propagates faster (but slower than 300 m/s) in the Westward direction. These results suggest that we might be observing the so‐called Pekeris mode, also consistent with the L1 pseudomode, reproduced by WACCM‐X simulations at MLT altitudes. They also rule out the previous hypothesis connecting the observations in South America to the Tsunami associated with the eruption because these perturbations are observed over Europe as well. Despite the progress, the L0 pseudomode in the MLT reproduced by WACCM‐X remains elusive to observations.
Light People: Prof. Donal D C Bradley (FRS)
Authors: Xia Ruidong , Hu Ying 
Published: August 2024

EditorialThe invention of organic light emitting diodes (LEDs) led to enormous excitement in both academe and industry in the late 1980’s. Flexibility, large area solution processability, roll-to-roll printing, low cost, and environmentally friendly are some of the advantages of organic semiconductor materials, which brought a new horizon for optoelectronics. Together with the achievement of organic solar cells, transistors, lasers, and amplifiers, this has demonstrated potential applications of organic semiconductors in displays, lighting, solar energy generation, electronics, sensing and imaging, and many aspects of photonics. In an enlightened conversation with Light: Science & Applications, Prof. Donal Bradley (FRS), a pioneer in the field, shared his deep insights on past, current, and future exciting developments of organic optoelectronic materials and devices. In particular, he expressed his opinion on the hot topics related to organic optoelectronics research and application, such as the relationship between organic and inorganic semiconductors and the challenge of electrically pumped organic lasers. As a successful scientist, Donal has also been co-founder of several organic optoelectronics innovation companies and research centers and a long-term academic administrator serving as a Head of Department, Centre Director, and Vice-Rector for Research at Imperial College, Head of the Mathematical, Physical, and Life Sciences Division at the University of Oxford, Vice-President for Research at King Abdullah University of Science and Technology and now Vice-President for Research and Innovation at NEOM U and Executive Director of the NEOM Education, Research and Innovation Foundation. Through this interview, we also explore the major roles and events in Donal’s career experience from the invention of the first conjugated polymer LED in the world to the set-up of entrepreneurial companies, from Cambridge to Sheffield, Imperial College, and Oxford, from the UK to overseas, and from the establishment of the Centre for Plastic Electronics in Imperial College to the set-up of the Oxford Suzhou Centre for Advanced Research (OSCAR). Before the end of the conversation, he also shares his interesting story of identifying a new species of Sea Bream, Acanthopagrus oconnorae (Bev Bradley’s Bream), named after his mother and wife, while fishing in the Red Sea.
An entropy and machine learning based approach for DDoS attacks detection in software defined networks
Authors: Hassan Amany I. , El Reheem Eman Abd , Guirguis Shawkat K. 
Published: August 2024

AbstractSoftware-defined networks (SDNs) have been growing rapidly due to their ability to provide an efficient network management approach compared to traditional methods. However, one of the major challenges facing SDNs is the threat of Distributed Denial of Service (DDoS) attacks, which can severely impact network availability. Detecting and mitigating such attacks is challenging, given the constantly evolving range of attack techniques. In this paper, a novel hybrid approach is proposed that combines statistical methods with machine-learning capabilities to address the detection and mitigation of DDoS attacks in SDN environments. The statistical phase of the approach utilizes an entropy-based detection mechanism, while the machine-learning phase employs a clustering mechanism to analyze the impact of active users on the entropy of the system. The k-means algorithm is used for clustering. The proposed approach was experimentally evaluated using three modern datasets, namely, CIC-IDS2017, CSE-CIC-2018, and CICIDS2019. The results demonstrate the effectiveness of the system in detecting and blocking sudden and rapid attacks, highlighting the potential of the proposed approach to significantly enhance security against DDoS attacks in SDN environments.
Proton conductivity of fluorite based rare earth titanates (LnxTi1−x)4O8−2x (Ln = Yb, Er, Ho, 0.667 ≤ x ≤ 0.765)
Authors: Gorshkov Nikolay , Baldin Egor , Stolbov Dmitry , Vorobieva Galina , Shatov Alexander , Shlyakhtina Anna 
Published: August 2024

An increase in REE concentration in solid solutions of the type (LnxTi1−x)4O8−2x (Ln = Yb, Er, Ho, 0.667 ≤ x ≤ 0.765) with a fluorite-based structure leads to an increase in proton conductivity. The maximum is reached for Ho3TiO6.5.
Biochemical characterization of paralyzed flagellum proteins A (PflA) and B (PflB) from Helicobacter pylori flagellar motor
Authors: Zhou Xiaotian , Khan Mohammad F. , Xin Yue , Chan Kar L. , Roujeinikova Anna 
Published: August 2024

Abstract
Motility by means of flagella plays an important role in the persistent colonization of Helicobacter pylori in the human stomach. The H. pylori flagellar motor has a complex structure that includes a periplasmic scaffold, the components of which are still being identified. Here, we report the isolation and characterization of the soluble forms of two putative essential H. pylori motor scaffold components, proteins PflA and PflB. We developed an on-column refolding procedure, overcoming the challenge of inclusion body formation in Escherichia coli. We employed mild detergent sarkosyl to enhance protein recovery and n-dodecyl-N,N-dimethylamine-N-oxide (LDAO)-containing buffers to achieve optimal solubility and monodispersity. In addition, we showed that PflA lacking the β-rich N-terminal domain is expressed in a soluble form, and behaves as a monodisperse monomer in solution. The methods for producing the soluble, folded forms of H. pylori PflA and PflB established in this work will facilitate future biophysical and structural studies aimed at deciphering their location and their function within the flagellar motor.
Endothelin-1 (ET-1) contributes to senescence and phenotypic changes in brain pericytes in diabetes-mimicking conditions
Authors: Edgerton-Fulton Mia , Abdul Yasir , Jamil Sarah , Ergul Adviye 
Published: August 2024

Abstract
Diabetes mediates endothelial dysfunction and increases the risk of Alzheimer’s disease and related dementias. Diabetes also dysregulates the ET system. ET-1-mediated constriction of brain microvascular pericytes (BMVPCs) has been shown to contribute to brain hypoperfusion. Cellular senescence, a process that arrests the proliferation of harmful cells and instigates phenotypical changes and proinflammatory responses in endothelial cells that impact their survival and function. Thus, we hypothesized that ET-1 mediates BMVPC senescence and phenotypical changes in diabetes-like conditions. Human BMVPCs were incubated in diabetes-like conditions with or without ET-1 (1 µmol/L) for 3 and 7 days. Hydrogen peroxide (100 µmol/L H2O2) was used as a positive control for senescence and to mimic ischemic conditions. Cells were stained for senescence-associated β-galactosidase or processed for immunoblotting and quantitative real-time PCR analyses. In additional experiments, cells were stimulated with ET-1 in the presence or absence of ETA receptor antagonist BQ-123 (20 μmol/L) or ETB receptor antagonist BQ-788 (20 μmol/L). ET-1 stimulation increased β-galactosidase accumulation which was prevented by BQ-123. ET-1 also increased traditional senescence marker p16 protein and pericyte-specific senescence markers, TGFB1i1, PP1CA, and IGFBP7. Furthermore, ET-1 stimulated contractile protein α-SMA and microglial marker ostepontin in high glucose suggesting a shift toward an ensheathing or microglia-like phenotype. In conclusion, ET-1 triggers senescence, alters ETA and ETB receptors, and causes phenotypical changes in BMVPCs under diabetes-like conditions. These in vitro findings need to be further studied in vivo to establish the role of ETA receptors in the progression of pericyte senescence and phenotypical changes in VCID.
An optimized AC side startup strategy of E‐STATCOM for ITER pulsed power electrical network
Authors: Deng Tianbai , Yuan Tao , Tao Jun , Shen Xianshun , Han Song , Zhu Qianlong , Fan Renjing , Mei Chong 
Published: August 2024

AbstractDuring the operation of the ITER machine, hundreds of MW/Var of active and reactive power will be exchanged with the grid. The E‐STATCOM scheme composed of the Modular Multilevel Converter (MMC) and split supercapacitor energy storage has been proposed to improve the power compensation performance of the existing reactive power compensation system in the previous study. However, one of the main technical challenges which is lack of research is to precharge all submodule capacitors and supercapacitors from zero to their nominal voltage values efficiently during a startup process. As the capacitance and operating voltage of supercapacitors are much different from capacitors in each submodule, the startup of E‐STATCOM is a more complicated process. To coordinate the energy exchange between submodule capacitors and supercapacitors, submodule capacitors and the grid, this paper presents an optimized four‐stage AC side startup strategy for the E‐STATCOM. The proposed method minimizes the use of current‐limiting resistors while suppressing the surge current in the zero‐voltage startup process of supercapacitors, in addition to optimizing the energy consumption. The pulse current charging, constant current charging and constant power charging strategies of supercapacitors are adopted in different charging stages, and the detailed coordinated control scheme between submodule capacitors and supercapacitors are described and analyzed. The effectiveness and performance of the proposed method are verified by simulation results and hardware‐in‐the‐loop (HIL) experiments.