bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metallic oxide nanoparticles stimulate blood coagulation independent of their surface charge
Authors: Steuer Heiko , Krastev Rumen , Lembert Nicolas 
Published: December 2013

AbstractPositively charged metallic oxides prevent blood coagulation whereas negatively charged metallic oxides are thrombogenic. This study was performed to examine whether this effect extends to metallic oxide nanoparticles. Oscillation shear rheometry was used to study the effect of zinc oxide and silicon dioxide nanoparticles on thrombus formation in human whole blood. Our data show that oscillation shear rheometry is a sensitive and robust technique to analyze thrombogenicity induced by nanoparticles. Blood without previous contact with nanoparticles had a clotting time (CT) of 16.7 ± 1.0 min reaching a maximal clot strength (CS) of 16 ± 14 Pa (G') after 30 min. ZnO nanoparticles (diameter 70 nm, +37 mV zeta‐potential) at a concentration of 1 mg/mL prolonged CT to 20.8 ± 3.6 min and provoked a weak clot (CS 1.5 ± 1.0 Pa). However, at a lower concentration of 100 µg/mL the ZnO particles dramatically reduced CT to 6.0 ± 0.5 min and increased CS to 171 ± 63 Pa. This procoagulant effect decreased at lower concentrations reaching the detection limit at 10 ng/mL. SiO2 nanoparticles (diameter 232 nm, −28 mV zeta‐potential) at high concentrations (1 mg/mL) reduced CT (2.1 ± 0.2 min) and stimulated CS (249 ± 59 Pa). Similar to ZnO particles, this procoagulant effect reached a detection limit at 10 ng/mL. Nanoparticles in high concentrations reproduce the surface charge effects on blood coagulation previously observed with large particles or solid metal oxides. However, nanoparticles with different surface charges equally well stimulate coagulation at lower concentrations. This stimulation may be an effect which is not directly related to the surface charge. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 897–902, 2014.
Effect of erythromycin‐doped calcium polyphosphate scaffold composite in a mouse pouch infection model
Authors: Ren Weiping P. , Song Wei , Esquivel Amanda O. , Jackson Nancy M. , Nelson Matthew , Flynn Jeffery C. , Markel David C. 
Published: December 2013

AbstractWe previously showed that strontium‐doped calcium polyphosphate (SCPP) scaffold with poly(vinyl alcohol) (PVA) coating extended the impregnated erythromycin (EM) release. In this study, we examined the bactericidal effect of EM‐doped SCPP (SCPPEM) scaffolds with PVA coating in a Staphylococcus aureus (S. aureus) infected mouse pouch. SCPP scaffolds with or without 5% EM, and SCPPEM scaffolds coated with PVA (with or without 5% EM) were prepared. Scaffolds were implanted in the pouch of BALB/c mice, followed by inoculation of 1 × 103 colony‐forming units of S. aureus. Mice were sacrificed 14 days after surgery. Pouch tissues and scaffolds were collected for histology, scanning electron microscopy, and microbiological analysis. In the absence of SCPP scaffolds, the pouch infection was eliminated by the host immune surveillance. In the presence of SCPP scaffolds, both the pouch tissues and scaffolds were infected, but SCPPEM scaffolds successfully inhibited bacterial growth. Although PVA coating of SCPPEM scaffolds enhanced bacterial growth, incorporation of EM into PVA coating inhibited growth. In conclusion, BALB/c mice were capable of eradicating a low grade S. aureus infection. SCPP protected S. aureus growth from host immune surveillance. Though PVA coating sustained EM release in vitro, it was unable to inhibit bacterial growth because PVA gel matrix provided a temporary shelter for bacteria to grow and slowed the EM release from SCPP scaffold. To guarantee a sufficient inhibition of bacterial growth at the initial stage, embedding EM or other antibiotics in the PVA coating is also essential. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1140–1147, 2014.
Eyewitness Memory for Typical and Atypical Weapons in Cognitive Context
Authors: McRae Kaichen , Sharps Matthew J. , Power Justin , Newton Alanna 
Published: December 2013

AbstractThe present research addressed eyewitness memory for weapons, specifically for a modern semi‐automatic pistol and an antique flintlock, in order to address the influence of weapon novelty on recall for the given weapon. Additionally, the effect of explanatory backstory was examined in the same context; respondents were given prior information, which was either consistent or inconsistent with the presence of the flintlock in the scene, in order to gauge the influence of appropriate or inappropriate explanatory cognitive context. Finally, the effects of these variables on line‐up identification of the ‘suspect’ holding the given weapon were addressed. The results showed that weapon type did not influence recall accuracy for given weapons, although explanatory backstory did have a significant effect here, as initially predicted. Both weapon type and explanatory backstory produced significant effects on weapon recall errors, with the exotic weapon and the more prosaic backstory producing larger numbers of mistakes. Neither of these variables was associated with significant differences in line‐up performance. These results indicate the importance of prior cognitive context, as well as the physical appearance of weapons, in a full understanding of eyewitness processing of scenes involving firearms. Copyright © 2013 John Wiley & Sons, Ltd.
Diagnostic accuracy of dynamic gadoxetic‐acid–enhanced MRI and PET/CT compared in patients with liver metastases from neuroendocrine neoplasms
Authors: Armbruster Marco , Zech Christoph J. , Sourbron Steven , Ceelen Felix , Auernhammer Christoph J. , Rist Carsten , Haug Alexander , Singnurkar Amit , Reiser Maximilian F. , Sommer Wieland H. 
Published: December 2013

PurposeTo evaluate the diagnostic accuracy of dynamic‐contrast–enhanced (DCE) MRI in comparison to both 18F‐FDG‐ and 68Ga‐DOTATATE‐PET/CT in patients with liver metastases of neuroendocrine neoplasms (NEN).Materials and MethodsThirty‐two patients with hepatic metastases from NEN were examined both in DCE‐MRI and positron emission tomography/computed tomography (PET/CT), using either 18F‐fluorodeoxyglucose (18F‐FDG) or 68Ga‐DOTATATE as tracer. DCE‐MRI was performed at 3 Tesla with Gd‐EOB‐DTPA acquiring 48 slices every 2.2 s for 5 min. Three regions of interest (ROIs) representing liver background and liver metastases were defined in fat‐saturated T1w three‐dimensional GRE MRI sequences in the hepatobiliary phase. Corresponding ROIs were then defined in the DCE‐MRI‐ and in the PET/CT‐dataset. Area under the curve (AUC) was calculated for the differentiation between metastases and liver background for DCE‐MRI and PET‐CT parameters.ResultsAUC was very high for SUVmean (mean standardized uptake value) derived from 68Ga‐DOTATATE‐ (AUC = 0.966), and 18F‐FDG‐PET/CT (AUC = 0.989). For DCE‐MRI parameters, arterial flow fraction and intracellular uptake fraction showed the highest AUCs (AUC = 0.826, AUC = 0.819, respectively). The combination of those two had an AUC of 0.949. The combination of DCE‐MRI and PET‐CT parameters resulted in the highest AUC.ConclusionBoth PET/CT parameters and DCE‐MRI perfusion parameters show a high diagnostic accuracy in the distinction between liver metastases and liver tissue. Our data suggest that both modalities provide complementary information. J. Magn. Reson. Imaging 2014;40:457–466. © 2013 Wiley Periodicals, Inc.
Texture‐based classification of liver fibrosis using MRI
Authors: House Michael J. , Bangma Sander J. , Thomas Mervyn , Gan Eng K. , Ayonrinde Oyekoya T. , Adams Leon A. , Olynyk John K. , St. Pierre Tim G. 
Published: December 2013

PurposeTo investigate the ability of texture analysis of MRI images to stage liver fibrosis. Current noninvasive approaches for detecting liver fibrosis have limitations and cannot yet routinely replace biopsy for diagnosing significant fibrosis.Materials and MethodsForty‐nine patients with a range of liver diseases and biopsy‐confirmed fibrosis were enrolled in the study. For texture analysis all patients were scanned with a T2‐weighted, high‐resolution, spin echo sequence and Haralick texture features applied. The area under the receiver operating characteristics curve (AUROC) was used to assess the diagnostic performance of the texture analysis.ResultsThe best mean AUROC achieved for separating mild from severe fibrosis was 0.81. The inclusion of age, liver fat and liver R2 variables into the generalized linear model improved AUROC values for all comparisons, with the F0 versus F1–4 comparison the highest (0.91).ConclusionOur results suggest that a combination of MRI measures, that include selected texture features from T2‐weighted images, may be a useful tool for excluding fibrosis in patients with liver disease. However, texture analysis of MRI performs only modestly when applied to the classification of patients in the mild and intermediate fibrosis stages. J. Magn. Reson. Imaging 2015;41:322–328.© 2013 Wiley Periodicals, Inc.
Prediction of the density of interfacial state produced by radiation in NMOS
Authors: Changshi Liu , Feng Li 
Published: December 2013

AbstractThis paper is aimed at the description of the mathematical relationships between energy position in the band gap and the density of interfacial state in N‐type metal‐oxide‐semiconductor (NMOS) capacitor irradiated by 60Co. Substantial differences of density of interfacial state caused by physical environment are observed. On the basis of non‐linear curve fitting, a typical numerical method is used to quantitatively analyze the energy‐dependent density of interfacial state. The simulations agree very well with the observed spectra (density of interfacial state versus the energy position in the band gap). The minimum correlation coefficient between the actual data and calculated one is 0.953. The average relative errors between the measured and modeled quantities do not exceed 6.32% in all considered cases. To my knowledge, it is the first time that the density of interfacial state can be predicted via energy level in the full range of band gap. Copyright © 2013 John Wiley & Sons, Ltd.
Gradient Structure‐Induced Temperature Responsiveness in Styrene/Methyl Methacrylate Gradient Copolymers Micelles
Authors: Zheng Chao , Huang Haiying , He Tianbai 
Published: December 2013

In this work, micelles are formed by gradient copolymer of styrene and methyl methacrylate in acetone–water mixture and their temperature responsiveness is investigated in a narrow range near room temperature. Three different kinds of structural transitions could be induced by temperature: unimers to micelle transition, shrinkage/stretching of micelles, and morphological transition from spherical micelles to vesicles. In addition, a model analysis on the interface of gradient copolymer micelle is made to better understand these phenomena. It is found that both position and composition of the interface could alter in response to the change in temperature. According to the experiments and model analysis, it is proposed that temperature responsiveness might be an intrinsic and universal property of gradient copolymer micelles, which only originates from the gradient structure.
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Manufacturing and Characterization of Controlled Foaming of Single Layers in Bilayer Constructs Differing in Pore Morphology
Authors: Saatchi Mersa , Behl Marc , Lendlein Andreas 
Published: December 2013

SummaryBilayer porous constructs from degradable polymers are considered as scaffold materials with beneficial elastic properties for cell culture application in tissue engineering. Here, we explored whether such bilayer constructs, in which only one layer was porous while the other layer enhanced the compressive mechanical properties, could be created by specific foaming of one layer with supercritical carbon dioxide (scCO2). The bilayer constructs of a poly(L‐lactide) (PLLA) and a poly(ϵ‐caprolactone) (PCL) layer were prepared by sequential injection molding and subsequent specific foaming with scCO2. Foaming conditions of T = 45 °C and P = 100 bar resulted in the formation of a porous PCL layer and a non‐porous PLLA layer. When the time intervals of the foaming process were increased the pore size was increased and the shape of the pores was changed from a circular to an unidirectional lamellar shape, which reduced the compressive elastic modulus of the porous PCL layer. Furthermore, the foaming process increased the adhesion force between the PLLA and PCL layers, which was attributed to a higher degree of diffusion of molten PCL into the PLLA layer. In summary, it was demonstrated that scCO2 foaming is a suitable method for the creation of layered scaffolds with only one foamed layer, in which the compressive elastic modulus and pore morphology of single porous layers can be controlled by the time interval of scCO2 process.
Does abnormal interhemispheric inhibition play a role in mirror dystonia?
Authors: Sattler Virginie , Dickler Maya , Michaud Martin , Meunier Sabine , Simonetta‐Moreau Marion 
Published: December 2013

AbstractThe presence of mirror dystonia (dystonic movement induced by a specific task performed by the unaffected hand) in the dominant hand of writer's cramp patients when the nondominant hand is moved suggests an abnormal interaction between the 2 hemispheres. In this study we compare the level of interhemispheric inhibition (IHI) in 2 groups of patients with writer's cramp, one with the presence of a mirror dystonia and the other without as well as a control group. The level of bidirectional IHI was measured in wrist muscles with dual‐site transcranial magnetic stimulation with a 10‐millisecond (short IHI) and a 40‐millisecond (long IHI) interstimulus interval during rest and while holding a pen in 9 patients with mirror dystonia 7 without mirror dystonia, and 13 controls. The group of patients without mirror dystonia did not differ from the controls in their IHI level. In contrast, IHI was significantly decreased in the group of patients with mirror dystonia in comparison with the group without mirror dystonia and the controls in both wrist muscles of both the dystonic and unaffected hand whatever the resting or active condition (P = 0.001). The decrease of IHI level in the group of patients with mirror dystonia was negatively correlated with the severity and the duration of the disease: the weaker the level of IHI, the more severe was the disease and the longer its duration. Interhemispheric inhibition disturbances are most likely involved in the occurrence of mirror dystonia. This bilateral deficient inhibition further suggests the involvement of the unaffected hemisphere in the pathophysiology of unilateral dystonia. © 2013 International Parkinson and Movement Disorder Society
Comprehensive integrated care for patients with sickle cell disease in a remote aboriginal tribal population in southern India
Authors: Nimgaonkar Vivek , Krishnamurti Lakshmanan , Prabhakar Hari , Menon Nandakumar 
Published: December 2013

AbstractBackgroundHealthcare delivery for sickle cell disease (SCD) can be challenging, in low resource settings. We studied the feasibility of delivering comprehensive SCD care in a community‐based network for remote, economically, and socially disadvantaged tribes in Gudalur, India.ProcedureWe reviewed medical records for all patients followed at the Gudalur Adivasi Hospital. We used published quality of care indicators to benchmark screening and routine healthcare maintenance.ResultsWe screened 9,646 individuals (60.4%) under the age of 30 of a population of 25,000 individuals. Of 111 active patients with SCD, 71% have had at least one annual comprehensive clinic visit at a median visit interval of 57 days. We provided pneumococcal immunization and penicillin prophylaxis to 56 (50%) patients and HU to 68 (61%). Median spleen size was 1 cm (range 1–6 cm), mean was Hb 9.3 g/dl and we reported a mean of 0.7 painful episodes/year. Premature deaths occurred in 19 patients at a median age of 23 years due to acute chest syndrome, sepsis, severe anemia, stroke, mesenteric infarction, puerperal sepsis, or sudden unexplained death. Healthcare maintenance met 11 of 17 published SCD quality of care indicators. Average cost was 1,343 Indian Rupees (INR) (approximately US$ 25) per hospitalization and 173 INR (approximately US$ 4) per clinic visit.ConclusionHigh quality comprehensive care for SCD can be delivered for a low income, aboriginal population in India through a community driven network of care. This model can serve as a template for healthcare delivery for SCD in low‐income communities. Pediatr Blood Cancer 2014;61:702–705. © 2013 Wiley Periodicals, Inc.
Identification of risk factors for an unsuccessful transition from pediatric to adult sickle cell disease care
Authors: Andemariam Biree , Owarish‐Gross Jasmine , Grady James , Boruchov Donna , Thrall Roger S. , Hagstrom J. Nathan 
Published: December 2013

BackgroundA successful transition from pediatric to adult sickle cell disease (SCD) care is paramount to continued improvements in survival. In order to enhance transition success, our pediatric SCD transition process was modified to include combined adult and pediatric provider clinics that incorporated participation by our local SCD community‐based organization. All children ages 16 and over participated in this newly‐formed transition program.ProcedureAfter 5 years of implementation of the modified SCD transition program, we retrospectively studied clinical and non‐clinical risk factors for an unsuccessful transition. Risk factor categories studied included patient demographics, transition clinic attendance, and disease severity.ResultsThirty‐two percent of patients did not transition successfully. Demographic factors such as gender, race, and type of insurance did not influence transition outcome, although travel distance to the adult SCD center was an identifiable risk factor for an unsuccessful transition. While transition clinic attendance rate did not affect transition outcomes, older age at first modified combined transition clinic visit was a significant risk factor for lack of transition. Patients with clinical markers of milder disease severity (SC and Sβ+ genotypes and no chronic transfusion therapy) were at higher risk for an unsuccessful transition than patients with severe disease.ConclusionsWe have identified several risk factors for lack of transition success which will allow us to modify our transition efforts going forward to capture this highest risk subset. Pediatr Blood Cancer 2014;61:697–701. © 2013 Wiley Periodicals, Inc.
A chemotherapy only therapeutic approach to pediatric Hodgkin lymphoma: AHOPCA LH 1999
Authors: Castellanos E. Mauricio , Barrantes José Carlos , Báez L. Fulgencio , Gamboa Yessica , Peña Armando , Alabi Soad , Bonilla Miguel , Wang Huaping , Metzger Monika L. , de Alarcón Pedro A. 
Published: December 2013

AbstractBackgroundAHOPCA is a collaborative group that designs uniform treatment regimens (protocols) for children diagnosed with cancer in Central America. Based on a preliminary report from one of the AHOPCA centers, AHOPCA adopted a treatment regimen to maintain a good event‐free survival (EFS) as well as eliminate radiation therapy from the treatment of children with Hodgkin lymphoma.ProcedureNewly diagnosed patients with histologically proven Hodgkin lymphoma were staged according to the Ann Arbor classification and divided into favorable (stage I, stage IIA, and IIIA) and unfavorable (stage IIB, IIIB, and IV) groups. Subjects classified as group 1 (favorable) were treated with six 28‐day cycles of chemotherapy (COPP/COPP ± ABV). Subjects classified as group 2 (unfavorable) were treated with eight 28‐day cycles of COPP/ABV chemotherapy.ResultsOf 269 patients registered, 216 were eligible for evaluation. The mean age at diagnosis was 7.5 years with a male to female ratio of 3.7–1. The predominant histology was nodular sclerosis (44%) but with a relatively high proportion of mixed cellularity (35.2%) The EFS at 5 and 10 years was 71% and 68%, respectively. There was a 14% rate of abandonment of therapy.ConclusionThis treatment regimen for children with Hodgkin lymphoma, when applied as a multi‐institutional regimen, had poorer outcome than our previously reported preliminary data and was inferior to the EFS reported in high‐income countries. The major contributor adversely affecting EFS in this report is abandonment of therapy. Given these results, AHOPCA initiated a concerted effort to decrease abandonment of therapy. Pediatr Blood Cancer 2014;61:997–1002. © 2013 Wiley Periodicals, Inc.
Dynamic Ultrasonic Nebulisation Extraction Coupled with Headspace Ionic Liquid‐based Single‐drop Microextraction for the Analysis of the Essential Oil in Forsythia suspensa
Authors: Yang Jinjuan , Wei Hongmin , Teng Xiane , Zhang Hanqi , Shi Yuhua 
Published: December 2013

ABSTRACTIntroductionIonic liquids have attracted much attention as an extraction solvent instead of traditional organic solvent in single‐drop microextraction. However, non‐volatile ionic liquids are difficult to couple with gas chromatography. Thus, the following injection system for the determination of organic compounds is described.ObjectiveTo establish an environmentally friendly, simple, and effective extraction method for preparation and analysis of the essential oil from aromatic plants.MethodsThe dynamic ultrasonic nebulisation extraction was coupled with headspace ionic liquid‐based single‐drop microextraction(UNE–HS/IL/SDME)for the extraction of essential oils from Forsythia suspense fruits. After 13 min of extraction for 50 mg sample, the extracts in ionic liquid were evaporated rapidly in the gas chromatography injector through a thermal desorption unit (5 s). The traditional extraction method was carried out for comparative study.ResultsThe optimum conditions were: 3 μL of 1‐methyl‐3‐octylimidazolium hexafluorophosphate was selected as the extraction solvent, the sample amount was 50 mg, the flow rate of purging gas was 200 mL/min, the extraction time was 13 min, the injection volume was 2 μL, and the thermal desorption temperature and time were 240 °C and 5 s respectively. Comparing with hydrodistillation (HD), the proposed method was environment friendly and efficient.ConclusionThe proposed method is environmentally friendly, time saving, with high efficiency and low consumption. It would extend the application range of the HS/SDME and would be useful especially for aromatic plants analysis. Copyright © 2013 John Wiley & Sons, Ltd.