bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombopoietin improves the functions of bone marrow endothelial progenitor cells via METTL16/Akt signalling of haematological patients with chemotherapy‐induced thrombocytopenia
Authors: Chen Hui , Jiao Yingying , Lin Chao , Fan Wenxuan , Li Lindi , Li Bo , Li Liang , Zeng Xiaoyuan , Li Zongpeng , Wei Hongfa , Zhang Yuming , Zhou Benjie , Chen Chun , Ye Jieyu , Yang Mo 
Published: August 2024

SummaryBone marrow endothelial progenitor cells (BM EPCs) are crucial in supporting haematopoietic regeneration, while the BM EPCs of haematological patients with chemotherapy‐induced thrombocytopenia (CIT) are unavoidably damaged. Therefore, the present study aimed to examine the effect of thrombopoietin (TPO) on the recovery of BM EPCs of CIT patients and to identify the underlying mechanisms. The cell functions were determined by 1,1‘‐dioctadecyl‐3,3,3’,3‘‐tetramethylindocarbocyanine perchlorate (Dil)–acetylated low‐density lipoprotein (Dil‐Ac‐LDL) uptake and fluorescein isothiocyanate (FITC)‐labeled Ulex europaeus agglutinin‐I (FITC‐UEA‐I) binding assay, as well as proliferation, migration and tube formation experiments. Endothelial cells were transfected with METTL16 lentivirus, followed by methylated RNA immunoprecipitation sequencing. Zebrafish with vascular defect was used as the in vivo model. TPO significantly improved the quantity and functions of BM EPCs from CIT patients in vitro and restored the subintestinal vein area of zebrafish with vascular defect in vivo. Mechanically, TPO enhanced the BM EPC functions through Akt signal mediated by METTL16, which was downregulated in BM EPCs of CIT patients and involved in the regulation of endothelial functions. The present study demonstrates that TPO improves the recovery of BM EPCs from CIT patients with haematological malignancies via METTL16/Akt signalling, which provides new insights into the role of TPO in treating CIT in addition to direct megakaryopoiesis.
Profiles of well‐being and their associations with self‐forgiveness, forgiveness of others, and gratitude among patients with rheumatic and musculoskeletal diseases
Authors: Charzyńska Edyta , Offenbächer Martin , Halverson Kjerstin , Hirsch Jameson K. , Kohls Niko , Hanshans Christian , Sirois Fuschia , Toussaint Loren 
Published: August 2024

AbstractObjectivesPatients with rheumatic and musculoskeletal diseases (RMDs) often experience poor well‐being. Common limitations of the studies on this topic involve using variable‐centred and deficit‐based approaches. In this study, we used the person‐centred approach to identify profiles of positive (life satisfaction and health status) and negative (depression, anxiety, fatigue, and stress) indicators of well‐being among patients with RMDs. Moreover, we tested self‐forgiveness, forgiveness of others, gratitude, and sociodemographics as contributors to latent profile membership.DesignA cross‐sectional questionnaire survey.MethodsUsing a latent profile analysis, we investigated well‐being profiles among 892 patients with RMDs (759 patients with arthritis and 133 with fibromyalgia [FM]) and examined the correlates of latent profile membership.ResultsWe identified four profiles of well‐being: (1) ‘life dissatisfaction’ (9.2%), (2) ‘high well‐being’ (43.4%), (3) ‘suboptimal well‐being’ (35.2%), and (4) ‘very poor well‐being’ (12.2%). Members of Profile 2 had higher levels of self‐forgiveness and gratitude than members of the remaining profiles, had higher levels of forgiveness of others than Profile 3, and were older than members of Profile 4. Moreover, members of Profile 2 had a higher proportion of patients with arthritis relative to those with FM than all other profiles and men to women than Profile 4.ConclusionsPatients with RMDs are heterogeneous in terms of well‐being. Self‐forgiveness, gratitude, and forgiveness of others may serve as psychological capital that enhances patients' well‐being. Special attention should be paid to patients with FM, women, and younger patients since they can be especially susceptible to poor well‐being.
Outcomes of the Victo™ adjustable artificial urinary sphincter in the treatment of male incontinence
Authors: Krhut Jan , Bartáková Lucie , Kondé Adéla , Sýkora Radek Paus , Rychlý Tomáš , Zachoval Roman 
Published: August 2024

ObjectivesTo report the clinical outcomes of the Victo™ (Promedon, Cordoba, Argentina) adjustable artificial urinary sphincter (AUS) implantation in a cohort of patients with severe urinary incontinence (UI) after prostate surgery.Patients and MethodsThis study enrolled patients with UI following prostate surgery who underwent a Victo implantation between May 2018 and December 2023. Patients were prospectively evaluated at baseline, and at 3 and 12 months after device activation, and thereafter annually. The 24‐h pad‐weight test (24hPWT) was used to assess severity of UI, while the Patient Global Impression of Improvement (PGI‐I) and patient satisfaction according to a Likert scale were used to measure patient‐reported outcomes.ResultsA total of 96 patients with a median (interquartile range [IQR]) age of 68 (65–72) years were included in the final analysis. The median (IQR) follow‐up was 3 (1–4) years. In all, 10 patients completed the 5‐year follow‐up. After the treatment, we observed a significant reduction in 24hPWT by the median of 83% (P < 0.001) at 3 months and by a median of 79% (P < 0.001) at 3 years. According to the PGI‐I, a total of 87%, 92%, 87%, 81%, 83%, and 50% (five of 10) of patients rated their condition/incontinence as ‘very much improved’, ‘much improved’ or ‘little improved’ at 3 months, 1‐, 2‐, 3‐, 4‐, and 5‐year follow‐up visits, respectively. The proportion of patients, who were ‘very satisfied’ or ‘satisfied’ with the treatment outcome was 79%, 80%, 75%, 69%, 80%, and 60% (six of 10) at 3 months, 1‐, 2‐, 3‐, 4‐, and 5‐years, respectively. There were a total of 13 (14%) device failures during the follow‐up period.ConclusionIn conclusion, our data suggest that Victo AUS significantly reduces the severity of UI after prostate surgery and provides a reasonably high patient‐reported satisfaction with treatment outcomes at mid‐term follow‐up.
Inheritance patterns of lower urinary tract symptoms in adults: a systematic review
Authors: Moore Lorcan , Malde Sachin , Dasgupta Prokar , Sahai Arun , Raison Nicholas 
Published: August 2024

ObjectiveTo compile and evaluate the heritability and inheritance patterns of lower urinary tract symptoms (LUTS) in adult cohorts.MethodsSearches of five databases (PubMed, Embase, APA PsycInfo, Global Health, and OVID Medline) commenced on 6 July 2024, resulting in 736 articles retrieved after deduplication. Studies evaluating heritability patterns, gene frequencies, and familial aggregation of symptoms were included for review. Screening and predefined eligibility criteria produced 34 studies for final review. A descriptive analysis of synthesised data was performed, adhering to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines. The Cochrane Risk of Bias in Non‐Randomised Studies of Interventions (ROBINS‐I) tool and the Johanna Briggs Institute checklist were used to evaluate these studies.ResultsTen of the 34 studies (29%) described general LUTS, 14 (41%) described symptoms due to benign prostatic enlargement (BPE), nine (26%) described urinary incontinence (UI; urge UI [UUI], stress UI [SUI] and mixed UI [MUI]), four (12%) described nocturia alone, two (6%) described overactive bladder (OAB), and four (13%) described other specific symptoms (frequency, postvoid residual urine volume). BPE symptoms, UI (MUI and UUI), nocturia alone, and frequency alone were associated with genetic predisposition, whilst OAB and SUI had more modest inheritance.ConclusionThe pathogenetic and pharmacological mechanisms fundamental to LUTS manifestation are highly heterogeneous. Further work is required to evaluate the inheritance patterns of LUTS more extensively.
CEO Compensation Contracts in Family Versus Nonfamily Firms: The Use of Nonfinancial Performance Measures
Authors: Afridi Adnan , Dirks Paula M. G. , Porumb Vlad‐Andrei , Zengin‐Karaibrahimoglu Yasemin 
Published: August 2024

ABSTRACTResearch Question/IssueThis study examines the association between ownership type—family versus nonfamily firms—and CEO family status—family CEO versus professional CEO—and the use of nonfinancial performance measures (NFPMs) in CEO compensation contracts.Research Findings/InsightsUsing a sample of 3143 firm‐year observations of S&P 500 nonfinancial firms from 2010 to 2018, we find that family firms place a significantly lower weight on NFPMs in CEO compensation contracts than nonfamily firms. Within family firms, we find that a significantly lower weight is placed on NFPMs in compensation contracts for family CEOs relative to those for professional CEOs. Furthermore, additional tests indicate that the negative association between family ownership and the weight placed on NFPMs is stronger (weaker) in firms with low (high) stakeholder visibility.Theoretical ImplicationsWe advance the academic literature on the selection of performance measures in compensation contracts by providing insight into the implications of family ownership and of a CEO's family ties for the use of NFPMs. The results suggest that because family firms have a good ability and a strong incentive to directly monitor and control their CEO's actions, NFPMs are less needed in CEO compensation contracts as a means to align goals. Furthermore, the effects we document are even stronger when the CEOs of family firms are family members.Practitioner/Policy ImplicationsThe results imply that while family firms may not need a high weight on NFPMs in CEO compensation contracts to monitor their CEOs' actions, goal alignment, and internal communication of nonfinancial targets, they may still need them for communication and signaling purposes when exposed to external stakeholder monitoring.
The Role of Employee Ownership, Financial Participation, and Decision‐Making in Corporate Governance: A Multilevel Review and Research Agenda
Authors: Del Sordo Elisa , Zattoni Alessandro 
Published: August 2024

ABSTRACTResearch Question/IssueThe allocation of return and control rights to employees has been somewhat overlooked in governance literature, but it has garnered interest from scholars across various fields. Our analysis of five decades of research integrates and juxtaposes theory and evidence from three independent yet intertwined domains: employee ownership, financial participation, and decision‐making. Our work synthesizes an extensive body of past and current findings and introduces a multilevel contingency framework to formulate novel theoretical, methodological, and contextual remedies.Research Findings/InsightsWe conducted a multilevel analysis of 184 articles published in reputable journals. Our results reveal complementary and substitutive relationships between employee financial participation and decision‐making and show that various contextual variables operating at different levels (i.e., individual, company and country) jointly impact employees behaviors and firm outcomes. Our findings help explain the mixed or ambiguous results of previous studies and offer novel theoretical and methodological pathways for future research.Theoretical/Academic ImplicationsOur study invites scholars to further investigate the antecedents and consequences of employee ownership, financial participation and decision‐making. Specifically, we recommend adopting theories and methods that illuminate the complex nature of the employee ownership construct, develop a multilevel understanding of the phenomenon, and analyze the moderating effects of various contextual variables.Practitioner/Policy ImplicationsInsights from our review can assist practitioners and policymakers in designing plans that allocate either one or both of ownership rights to employees, enhancing their understanding of the role and impact of diverse contextual factors operating at various levels.
Do recently translocated black‐footed Albatross (Phoebastria nigripes) chicks respond to artificial social attraction?
Authors: Casillas Daniela , Young Lindsay C. , Harmon Kristen C. , Wilhite Chad J. , Vanderwerf Eric A. , Price Melissa R. 
Published: August 2024

AbstractTranslocations of chicks are increasingly being used in seabird restoration projects, along with social attraction of adults using acoustic and visual cues, to establish new colonies or re‐establish extirpated colonies. Many seabird species exhibit high rates of natal philopatry, where most chicks return to the nesting colonies from which they fledged. This makes them ideal candidates for translocation projects since they have a high likelihood of returning to translocation sites if they are relocated prior to imprinting on a natal site. Starting in 2017, Black‐footed Albatross (BFAL) chicks were translocated from populations in the low‐lying Northwestern Hawaiian Islands, where they face habitat loss due to sea level rise, to the higher elevation island of O‘ahu, in an attempt to establish a new colony for this species. Additionally, social attraction was utilized at the site to attract potential nesting adults and provide social stimuli for the translocated chicks. Our study examined the response of translocated BFAL chicks to visual and audio stimuli inside a mammalian predator exclusion fence at James Campbell National Wildlife Refuge on the island of O‘ahu. Decoys constructed in two different poses, representing courtship and resting postures of adult BFAL, were placed in various combinations with playback speakers around the perimeter of artificial shelters. Motion‐activated cameras were used to record and compare the number of visits by chicks to different combinations of visual and acoustic stimuli. We found the number of visits was highest at setups that included a combination of a decoy pair and a playback speaker, suggesting that a combination of visual and audio cues of adult BFAL are most attractive to the chicks. Future studies are needed to evaluate the long‐term impacts of exposure to artificial visual and audio stimuli as chicks on return rates to translocation site and social behavior as adults.
Determining Predictors of Actual Living Kidney Donation Based on Potential Donor Characteristics
Authors: Meinders Andrea M. , Graviss Edward A. , Nguyen Duc T. , Daw Jonathan , Lentine Krista L. , Peipert John Devin , Gaber Ahmed Osama , Axelrod David A. , Weng Francis L. , Waterman Amy D. 
Published: August 2024

ABSTRACTBackgroundLiving donor kidney transplantation is the optimal treatment for end‐stage kidney disease; however, few living donor candidates (LDCs) who begin evaluation actually donate. While some LDCs are deemed medically ineligible, others discontinue for potentially modifiable reasons.MethodsAt five transplant centers, we conducted a prospective cohort study measuring LDCs’ clinical and psychosocial characteristics, educational preparation, readiness to donate, and social determinants of health. We followed LDCs for 12 months after evaluation to determine whether they donated a kidney, opted to discontinue, had modifiable reasons for discontinuing, were medically ineligible, or had other recipient‐related reasons for discontinuing.ResultsAmong 2184 LDCs, 18.6% donated, 38.2% opted to or had modifiable reasons for discontinuing, and 43.2% were deemed ineligible due to medical or recipient‐related reasons. Multivariable analyses comparing successful LDCs with those who did not complete donation for modifiable reasons (N = 1241) found that LDCs who discussed donation with the recipient before evaluation (OR, 2.31; 95% CI, 1.54–3.46), had completed high school (OR, 2.01; 95% CI, 1.21–3.35), or were a “close relation” to their recipient (OR, 1.89; 95% CI, 1.33–2.69) were more likely to donate. Conversely, LDCs who reported religion as important (OR, 0.55; 95% CI, 0.38–0.80), were Non‐White (OR, 0.70; 95% CI, 0.49–1.00), or had overall higher anxiety scores (OR, 0.92; 95% CI, 0.86–0.99) were less likely to donate.ConclusionWith fewer than a fifth of LDCs donating, developing programs to provide greater emotional support and facilitate open discussions between LDCs and recipients earlier may increase living donation rates.
Risk Factors and Outcomes Associated With the Development of Persistent Acute Kidney Injury in Non‐Renal Solid Organ Transplant Recipients: Systematic Review and Meta‐Analysis
Authors: Saraiva Ivan E. , Hamahata Natsumi , Sakhuja Ankit , Chen Xinlei , Minturn John S. , Sanchez Pablo G. , Chan Ernest G. , Kaczorowski David J. , Al‐Khafaji Ali , Kellum John A. , Gómez Hernando 
Published: August 2024

ABSTRACTPersistent acute kidney injury (pAKI), compared with acute kidney injury (AKI) that resolves in <72 h, is associated with worse prognosis in critically ill patients. Definitions and prognosis of pAKI are not well characterized in solid organ transplant patients. Our aims were to investigate (a) definitions and incidence of pAKI; (b) association with clinical outcomes; and (c) risk factors for pAKI among heart, lung, and liver transplant recipients. We systematically reviewed the literature including PubMed, Embase, Web of Science, and Cochrane from inception to 8/1/2023 for human prospective and retrospective studies reporting on the development of pAKI in heart, lung, or liver transplant recipients. We assessed heterogeneity using Cochran's Q and I2. We identified 25 studies including 6330 patients. AKI (8%–71.6%) and pAKI (2.7%–55.1%) varied widely. Definitions of pAKI included 48–72 h (six studies), 7 days (three studies), 14 days (four studies), or more (12 studies). Risk factors included age, body mass index (BMI), diabetes, preoperative chronic kidney disease (CKD), intraoperative vasopressor use, and intraoperative circulatory support. pAKI was associated with new onset of CKD (odds ratio [OR] 1.41–11.2), graft dysfunction (OR 1.81–8.51), and long‐term mortality (OR 3.01–13.96), although significant heterogeneity limited certainty of CKD and graft dysfunction outcome analyses. pAKI is common and is associated with worse mortality among liver and lung transplant recipients. Standardization of the nomenclature of AKI will be important in future studies (PROSPERO CRD42022371952).
F‐words ingredients of non‐invasive interventions for young ambulant children with cerebral palsy: A scoping review
Authors: Leite Hércules Ribeiro , de Sousa Junior Ricardo Rodrigues , Souto Deisiane Oliveira , Medeiros e Silva Jaíza Marques , de Lima Arthur Felipe Barroso , de Miranda Drumond Carolyne , Policiano Eliane Beatriz Cunha , Marques Ariane Cristina , de Carvalho Chagas Paula Silva , Longo Egmar 
Published: August 2024

AbstractAimTo map the ingredients of non‐invasive interventions provided to young ambulant children with cerebral palsy.MethodArticles were screened and each study's characteristics extracted. The intervention ingredients were described in terms of the Rehabilitation Treatment Specification System and linked to the ‘F‐words’. Results were interpreted and validated by a patient and public involvement group.ResultsSixty‐one papers were included, of which 55.5% were classified as randomized controlled trial design studies. The selected studies included a total of 2187 children (mean age range 3 months to 5 years 11 months), most from high‐income countries. The included studies investigated a total of 27 interventions, which together presented ingredients representing all F‐words, in the following order of frequency: ‘fitness’ (e.g. strength and endurance training), ‘functioning’ (e.g. active and repetitive practice of a task), ‘family’ (e.g. context‐focused therapy), ‘fun’ (e.g. inclusion of child‐friendly activities), ‘friends’ (e.g. group activities), and ‘future’ (e.g. didactic information sharing). Thus, ingredients related to the F‐word ‘future’ were the most infrequently reported.InterpretationTherapists and families need to be aware of the most appropriate match between the F‐word goals, ingredients, and targets. Finally, ‘fun’, ‘friends’, and ‘future’ should be addressed as potential outcomes in future studies.
Fantasies of Rousseau: A Lacanian View of Natural Education In and Beyond Émile
Authors: Stock Nicholas 
Published: August 2024

AbstractBeginning with the question of the usefulness of Rousseau's Émile for contemporary education, this article explores the fantasy held by educational thinkers and practitioners regarding Rousseau's concept of Natural Education. Using French psychoanalyst Jacques Lacan's theory of fantasy, which is based on a relationship between the subject and the object of their desire, Nicholas Stock breaks down Natural Education in a number of ways. Initially, he explores the signifier of nature as an object of desire for both Rousseau and the contemporary educationalist. Next, he examines how Rousseau deploys the signifier in Émile and how this creates an ontology of the child that claims to understand their nature while designating them as Other. This point opens up discussion of desires in light of Lacan's examination of Marquis de Sade and sadism. Equally, in exploring Rousseau's dialectical relationship with Sade, Stock goes on to discuss how the fantasy of nature in Rousseau opens up possibilities of sadistic desire. Finally, he concludes the article by deconstructing the binary upheld between nature and culture through an exploration of pastoral literature. It is this pastoralism that gives a desirable quality to nature, thus sustaining its fantasy in educational circles.
Long‐term effects of management practices on soil water, yield and water use of dryland wheat: A global meta‐analysis
Authors: Adil Muhammad , Lv Fenglin , Li Tingting , Chen Yi , Gul Isma , Lu Heli , Lu Siqi , Qiu Lin 
Published: August 2024

AbstractSoil water conservation in dryland agriculture mainly depends on precipitation. We chose 35 long‐term experiments and analysed the data by using meta‐analysis to check how fallow management methods affect soil water storage of dryland winter wheat planting (SWS), precipitation storage efficiency (PSE), crop yield and water use efficiency (WUE). No‐tillage (NT), compared to conventional tillage (CT) in the fallow period, increased PSE, SWS, grain yield and WUE by 32.9%, 27.1%, 30.5% and 22.6%, respectively. Reduced tillage (RT) and subsoil tillage (ST) increased PSE by 15.2% and 11.7%, SWS by 17.4% and 15.0% and grain yield by 15.5 and 13.8%, respectively, but these had a non‐significant effect on WUE. The conservation tillage methods interacted significantly with the residue management and fallow mulching practices. Compared to CT, the conservation tillage methods with fallow mulching increased PSE, SWS, grain yield and WUE, but the growing of cover crops (designated as biological mulching) decreased PSE, SWS and grain yield by 17.3%, 13.0% and 32.0%, and had a non‐significant impact on WUE. Under the condition of straw mulching, NT increased PSE, SWS, grain yield and WUE by 43.7%, 38.1%, 40.6% and 42.9%, respectively, compared to CT. NT and RT increased the PSE, SWS and WUE, under normal mean annual precipitation (MAP), however, ST increased these observations under wet MAP, compared to CT. The effects of tillage methods varied with soil texture, and they were highly interrelated with water conservation, wheat yield and water use. We conclude that compared to conventional tillage, the conservation tillage methods increased soil water conservation during the fallow period, which increased wheat yield and water use. Moreover, NT with or without residue retention increased the fallow water conservation and wheat yield. Crop residues should be retained while applying RT and ST to grow winter wheat in dryland regions.