bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Enantioenriched Isoindolinones from Chiral Phase‐Transfer‐Catalyzed Intramolecular Aza‐Michael Reactions.
Authors: Sallio Romain , Lebrun Stephane , Schifano‐Faux Nadege , Goossens Jean‐Francois , Agbossou‐Niedercorn Francine , Deniau Eric , Michon Christophe 
Published: January 2014

AbstractOptimized reaction conditions including a optically active tris cinchonium catalyst are developed for the intramolecular aza‐Michael reactions of benzamide substrates to afford isoindolinones with moderate enantioselectivities.
ChemInform Abstract: Enantioselective Synthesis of Quaternary 3‐Aminooxindoles via Organocatalytic Asymmetric Michael Addition of 3‐Monosubstituted 3‐Aminooxindoles to Nitroolefins.
Authors: Cui Bao‐Dong , Han Wen‐Yong , Wu Zhi‐Jun , Zhang Xiao‐Mei , Yuan Wei‐Cheng 
Published: January 2014

AbstractThis method yields 3‐aminooxindoles with adjacent quaternary and tertiary stereocenters in good yields and with good diastereo‐ and enantioselectivities under mild reaction conditions.
ChemInform Abstract: Electrosynthesis of Imidazolium Carboxylates.
Authors: de Robillard Guillaume , Devillers Charles H. , Kunz Doris , Cattey Helene , Digard Eric , Andrieu Jacques 
Published: January 2014

AbstractFor the first time the synthesis of imidazolium carboxylates is efficiently achieved by electrochemical reduction of imidazolium salts under very mild conditions.
ChemInform Abstract: Cyclocondensation of β‐(Aryl/Heteroaryl)methylaminoenones with Thionyl Chloride: A Facile General Approach for the Synthesis of 2,4‐Bis(het)aryl‐5(het)aroylthiazoles.
Authors: Swaroop Toreshettahally R. , Ila Hiriyakkanavar , Rangappa Kanchugarakoppal 
Published: January 2014

AbstractThe reported strategy allows a novel entry to 2,4,5‐trisubstituted thiazoles avoiding the limitations of Hantzsch type condensations.
ChemInform Abstract: Copper‐Catalyzed Synthesis of Benzo[b]thiophenes and Benzothiazoles Using Thiocarboxylic Acids as a Coupling Partner.
Authors: Yu Hui , Zhang Meishu , Li Yuzhe 
Published: January 2014

AbstractSubstrates with a methyl group in α‐position of the PPh3‐group do not react under these conditions to yield the corresponding 3‐methylbenzothiophene.
ChemInform Abstract: Synthesis of Tetrazole Containing 1,2,3‐Thiadiazole Derivatives via U‐4CR and Their anti‐TMV Activity.
Authors: Fan Zhi‐Jin , et al. et al. 
Published: January 2014

AbstractA series of novel tetrazole‐containing thiadiazole derivatives (IV) (13 examples) are designed and synthesized using an Ugi four‐component reaction.
ChemInform Abstract: Formation of Highly Substituted Tetrahydropyranones: Application to the Total Synthesis of Cyanolide A.
Authors: Tay Gidget C. , Gesinski Michael R. , Rychnovsky Scott D. 
Published: January 2014

AbstractThe condensation of α‐hydroxy silyl enol ethers with aldehydes is optimized in order to synthesize 2,6‐disubstituted 3,3‐dimethyltetrahydropyran‐4‐ones.
ChemInform Abstract: Rhodium(III)‐Catalyzed C—H Activation Mediated Synthesis of Isoquinolones from Amides and Cyclopropenes.
Authors: Hyster Todd K. , Rovis Tomislav 
Published: January 2014

AbstractA method to access 4‐substituted isoquinolines is developed using the Rh(III)‐catalyzed reaction of O‐pivaloyl benzhydroxamic acids with cyclopropenes.
ChemInform Abstract: Efficient Construction of C=N Double Bonds via Acceptorless Dehydrogenative Coupling.
Authors: Sun Xiang , Hu Yu , Nie Shao‐zhen , Yan Yun‐yun , Zhang Xue‐jing , Yan Ming 
Published: January 2014

AbstractAn unprecedented strategy for the direct imidation of sp3 C—H bonds is presented.
ChemInform Abstract: Conformationally Assisted Lactamizations for the Synthesis of Symmetrical and Unsymmetrical Bis‐2,5‐diketopiperazines.
Authors: Katritzky Alan R. , et al. et al. 
Published: January 2014

AbstractThe new lactamization strategy to convert open‐chain N‐Cbz‐protected‐peptidoyl benzotriazolides uses proline as a turn introducer into symmetrical diketopyrazines [cf.
ChemInform Abstract: Stereodivergent Access to cis‐ and trans‐3,5‐Disubstituted 1,4‐Thiazane 1‐Oxides by Cyclization of Homochiral β‐Amino Sulfoxides and Sulfones. The Preparation of Isomeric Ant Venom Alkaloids.
Authors: Soederman Stefan C. , Schwan Adrian L. 
Published: January 2014

Abstract(E)‐1‐Alkenyl‐2‐aminoalkyl sulfoxides undergo base‐promoted trans‐selective cyclization to give trans‐3,5‐disubstituted thiazanes.
ChemInform Abstract: Facile One‐Pot Assembly of Imidazotriazolobenzodiazepines via Indium(III)‐Catalyzed Multicomponent Reactions.
Authors: Nguyen Huy H. , Palazzo Teresa A. , Kurth Mark J. 
Published: January 2014

AbstractThe simple protocol allows the synthesis of the title compounds via tandem InCl3‐catalyzed cyclocondensation and intramolecular azide‐alkyne 1,3‐dipolar cycloaddition.
ChemInform Abstract: Insertion of Reactive Rhodium Carbenes into Boron—Hydrogen Bonds of Stable N‐Heterocyclic Carbene Boranes.
Authors: Li Xiben , Curran Dennis P. 
Published: January 2014

AbstractThis method also works with substituted imidazole‐borane adducts as well as 1,2,4‐triazole‐derived borane adducts.
ChemInform Abstract: The Preparation of Trisubstituted Alkenyl Nucleoside Phosphonates under Ultrasound‐Assisted Olefin Cross‐Metathesis.
Authors: Sari Ozkan , Hamada Manabu , Roy Vincent , Nolan Steven P. , Agrofoglio Luigi A. 
Published: January 2014

AbstractTitle compounds (III) undergo regioselective chemoenzymatic deacetylation.The best results are obtained with Candida antarctica lipase B to afford monoalcohol (IV) which reacts with various pyrimidine and purine derivatives under Mitsunobu conditions.
ChemInform Abstract: SnCl4/Sn Catalyzed Chemoselective Reduction of Glycopyranosyl Azides for the Synthesis of Diversely Functionalized Glycopyranosyl Chloroacetamides.
Authors: Sahoo Laxminarayan , Singhamahapatra Anadi , Paul Katuri J. V. , Loganathan Duraikkannu 
Published: January 2014

AbstractThe method is suitable for various protecting groups as well as for sugar azides bearing alkene or alkyne functional groups (not shown).
ChemInform Abstract: Concise Synthesis of the Multiply Oxygenated ABC‐Ring System of the Dihydro‐β‐agarofurans.
Authors: Ishiyama Tomochika , Urabe Daisuke , Fujisawa Hiroki , Inoue Masayuki 
Published: January 2014

AbstractDiels—Alder reactions of the lactones (I) and (II) is optimized with respect to selective production of the exo‐adduct (III) thus establishing the C5‐ and C10‐tetrasubstituted and C2‐alkoxy‐substituted stereocenter for the conversion to the ABC‐ring fragment (IV*) of dihydro‐β‐agarofurans.
ChemInform Abstract: Synthesis of 6‐Sulfonatomethyl Thioglycosides by Nucleophilic Substitution: Methods to Prevent 1→6 Anomeric Group Migration of Thioglycoside 6‐O‐Triflates.
Authors: Herczeg Mihaly , Mezoe Erika , Eszenyi Daniel , Lazar Laszlo , Csavas Magdolna , Bereczki Ilona , Antus Sandor , Borbas Aniko 
Published: January 2014

AbstractIt is found that α‐thioglycosides and conformationally locked beta‐thioglycosides can be successfully transformed into biologically 6‐sulfonatomethyl derivatives.
ChemInform Abstract: Double Asymmetric Induction in Organocatalyzed Aldol Reactions: Total Synthesis of (+)‐2‐epi‐Hyacinthacine A2 and (‐)‐3‐epi‐Hyacinthacine A1.
Authors: Marjanovic Jasna , Divjakovic Vladimir , Matovic Radomir , Ferjancic Zorana , Saicic Radomir N. 
Published: January 2014

AbstractThe aldol reaction of dioxanone with the chiral aldehyde (I) in the presence of D‐ or L‐proline allows access to the title compounds.
Atypical cytologic diagnostic category in EUS‐FNA of the pancreas: Follow‐up, outcomes, and predictive models
Authors: Alston Evan , Bae Sejong , Eltoum Isam A. 
Published: January 2014

BACKGROUNDThe objective of this study was to assess how atypical diagnostic category (ADC) is followed up, its outcomes, and the predictors that are associated with subsequent diagnosis of neoplasm/malignancy.METHODSWe reviewed pancreatic endoscopic ultrasound fine‐needle aspiration (EUS‐FNA) with ADC and compared the rate of detection of neoplasms after a repeat FNA, a biopsy/resection, or a clinical follow‐up following ADC. Logistic regression was used to determine the factors associated with the diagnosis of a neoplastic or a malignant lesion following ADC. Predictive probability for each case was calculated on the basis of the significant predictors, and whether it improved diagnostic performance was assessed.RESULTSOf 3832 cases that received pancreatic EUS‐FNAs, 187 (4.9%) were ADC. A total of 93 neoplasms (55%), including 61 carcinomas (36%), were detected after an atypical cytologic diagnosis. Similar rates of detecting neoplasms were observed after repeat FNA or biopsy/resection but higher than after clinical follow‐up. The presence of a mass, history of alcohol use, and absence of a history of pancreatitis were significant predictors of a higher rate of diagnosis of neoplasm. Weight loss and bile flow obstruction were more likely to be associated with higher rates of carcinoma. Predictive probability demonstrated a wide range of risk and changed the ambiguous diagnosis to informative in 30% of cases.CONCLUSIONSADC of pancreas is associated with a high risk of benign and malignant neoplasms regardless of the method of follow‐up. The presences of a mass, alcohol use, and absence of a history of pancreatitis are significant predictors of a diagnosis of neoplasm, whereas weight loss and bile duct obstruction are significant predictors of ductal carcinoma following an ADC. Cancer (Cancer Cytopathol) 2014;122:428–434. © 2013 American Cancer Society.
The Influence of N‐doped Carbon Materials on Supported Pd: Enhanced Hydrogen Storage and Oxygen Reduction Performance
Authors: Kong Xiang‐Kai , Chen Qian‐Wang , Lun Zheng‐Yan 
Published: January 2014

AbstractN‐doped graphene has become an important support for Pd in both hydrogen storage and catalytic reactions. The molecular orbitals of carbon materials (including graphene, fullerene, and small carbon clusters) and those of the supported Pd species will hybrid much stronger as N dopants are introduced, owing to the increased electrostatic attraction at the interface. This enhances the carbon substrates′ catching force for the supported Pd, preventing its leaching and aggregation in many practical applications. The better dispersion and stabilization of Pd nanoparticles, which are induced by various carbon supports with N‐doping, are pleasing to us and could increase their efficiency and facilitate their recycling during various reaction processes in several fields.
Cooperative and Diminutive Effects of Pnicogen Bonds and Cation–π Interactions
Authors: Li Qingzhong , Zhuo Hongying , Yang Xin , Cheng Jianbo , Li Wenzuo , Loffredo Robert E. 
Published: January 2014

AbstractThe interplay between pnicogen bonds and cation–π interactions has been investigated at the MP2/aug‐cc‐pVDZ level. Interesting cooperative and diminutive effects are observed when pnicogen bonds and cation–π interactions coexist in the same complex. These effects have been analyzed in terms of the structural, energetic, and charge‐transfer properties of the complexes. The variations in electron density at critical points of the intermolecular bond have been used to analyze bond strengthening or weakening. The nature of the interactions and the mechanisms of cooperative and diminutive effects have been studied by means of symmetry‐adapted perturbation theory and molecular electrostatic potentials.
Distance from forest edge affects bee pollinators in oilseed rape fields
Authors: Bailey Samantha , Requier Fabrice , Nusillard Benoît , Roberts Stuart P. M. , Potts Simon G. , Bouget Christophe 
Published: January 2014

AbstractWild pollinators have been shown to enhance the pollination of Brassica napus (oilseed rape) and thus increase its market value. Several studies have previously shown that pollination services are greater in crops adjoining forest patches or other seminatural habitats than in crops completely surrounded by other crops. In this study, we investigated the specific importance of forest edges in providing potential pollinators in B. napus fields in two areas in France. Bees were caught with yellow pan traps at increasing distances from both warm and cold forest edges into B. napus fields during the blooming period. A total of 4594 individual bees, representing six families and 83 taxa, were collected. We found that both bee abundance and taxa richness were negatively affected by the distance from forest edge. However, responses varied between bee groups and edge orientations. The ITD (Inter‐Tegular distance) of the species, a good proxy for bee foraging range, seems to limit how far the bees can travel from the forest edge. We found a greater abundance of cuckoo bees (Nomada spp.) of Andrena spp. and Andrena spp. males at forest edges, which we assume indicate suitable nesting sites, or at least mating sites, for some abundant Andrena species and their parasites (Fig. ). Synthesis and Applications. This study provides one of the first examples in temperate ecosystems of how forest edges may actually act as a reservoir of potential pollinators and directly benefit agricultural crops by providing nesting or mating sites for important early spring pollinators. Policy‐makers and land managers should take forest edges into account and encourage their protection in the agricultural matrix to promote wild bees and their pollination services.Left, a Nomada sp male; right, an Andrena sp male.image
Testing the ecological consequences of evolutionary change using elements
Authors: Jeyasingh Punidan D. , Cothran Rickey D. , Tobler Michael 
Published: January 2014

AbstractUnderstanding the ecological consequences of evolutionary change is a central challenge in contemporary biology. We propose a framework based on the ~25 elements represented in biology, which can serve as a conduit for a general exploration of poorly understood evolution‐to‐ecology links. In this framework, known as ecological stoichiometry, the quantity of elements in the inorganic realm is a fundamental environment, while the flow of elements from the abiotic to the biotic realm is due to the action of genomes, with the unused elements excreted back into the inorganic realm affecting ecological processes at higher levels of organization. Ecological stoichiometry purposefully assumes distinct elemental composition of species, enabling powerful predictions about the ecological functions of species. However, this assumption results in a simplified view of the evolutionary mechanisms underlying diversification in the elemental composition of species. Recent research indicates substantial intraspecific variation in elemental composition and associated ecological functions such as nutrient excretion. We posit that attention to intraspecific variation in elemental composition will facilitate a synthesis of stoichiometric information in light of population genetics theory for a rigorous exploration of the ecological consequences of evolutionary change.
New insights into the age and formation of the Ankarokaroka lavaka and its associated sandy cover (NW Madagascar, Ankarafantsika natural reserve)
Authors: Mietton Michel , Cordier Stéphane , Frechen Manfred , Dubar Michel , Beiner Monique , Andrianaivoarivony Rafolo 
Published: January 2014

ABSTRACTLavaka represent a typical erosional landform in Madagascar. The chronology of their formation remains, however, under discussion. Our research focuses on the Ankarokaroka lavaka, a spectacular landform located in NW Madagascar (Ankarafantsika natural reserve), which is characterized by the presence of sandy units of regional extension at its top. The two main units correspond to white and red sands, and are closely associated with specific vegetations (dry dense forest for the white sands, savannah grasslands for the red sands). We applied a geochronological approach based on Optically Stimulated Luminescence (for the coversands) associated with radiocarbon dating performed on archaeological remains found at the contact between the sands and the lavaka. The combination of this approach with field work and sedimentological analyses makes it possible to show that the sands experienced a complex history, both in terms of sedimentation and post‐sedimentary pedogenesis (podzolization of the white sands, rubefaction of the red sands). The numerical ages furthermore indicate that the Ankarokaroka lavaka formed between 18.5 ± 2.3 ka ago and the 14th century AD. The present study demonstrates that this lavaka has a climatic origin, and highlights the potential of OSL to date sediments associated with Madagascar lavaka. Copyright © 2014 John Wiley & Sons, Ltd.
Interaction of functionalized fullerenes and metal accumulation in Daphnia magna
Authors: Yu Zhi-Guo , Wang Wen-Xiong 
Published: January 2014

Abstract

In aquatic environments, transformation of pollutants by association with functionalized carbon-based nanoparticles can dramatically change their cycling pathways. The present study quantified the uptake and depuration behavior of cadmium and zinc bound with functionalized fullerene nanoparticles (f-nC60) in a freshwater cladoceran, Daphnia magna, in a well-dispersed medium. Metal uptake proceeded with a linear pattern during the 8-h exposure period, and the uptake rate constants (ku) were 1.3-fold to 1.4-fold higher for Cd or comparable for Zn bound with f-nC60 than those of the free ones. The assimilation efficiencies of Cd and Zn bound with f-nC60 were significantly enhanced when compared with those metals bound with algal food. Furthermore, the depuration of metals bound with f-nC60 was relatively slower compared to the depuration of metals bound with carbon nanotubes. A longer exposure to f-nC60 resulted in an even slower depuration of metals. The authors conclude that metal binding with f-nC60 as modified nanoparticles could serve as a new pathway for the elevated metal accumulation in Daphnia. Environ Toxicol Chem 2014;33:1122–1128. © 2014 SETAC
Lifelong exposure to methylmercury disrupts stress-induced corticosterone response in zebra finches (Taeniopygia guttata)
Authors: Moore Christina S. , Cristol Daniel A. , Maddux Sarah L. , Varian-Ramos Claire W. , Bradley Eric L. 
Published: January 2014

Abstract

Mercury can disrupt the endocrine systems of mammals and fish, but little is known about its effects on avian hormones. The authors employed an experimental manipulation to show that methylmercury suppresses the stress-induced corticosterone response in birds, an effect previously unreported in the literature. Corticosterone regulates many normal metabolic processes, such as the maintenance of proper blood glucose levels during stressful daily fasting; an inability to increase corticosterone levels in response to stressors renders a bird less able to face a wide array of environmental challenges. The authors studied reproductively mature zebra finches that had been exposed to 0.0 µg/g, 0.3 µg/g, 0.6 µg/g, 1.2 µg/g, or 2.4 µg/g (wet wt) dietary methylmercury throughout their life (i.e., from the egg onward). In contrast to some field studies, the present study found no significant change in baseline plasma corticosterone concentrations attributable to chronic methylmercury exposure. However, a comparison between the baseline corticosterone levels and levels after 30 min of handling stress revealed that the ability of birds to mount a stress response was reduced with increasing blood total mercury concentration. These results are consistent with adrenal corticoid disruption caused by chronic mercury exposure and mirror a similar study on free-living nestling songbirds exposed to environmental mercury. Environ Toxicol Chem 2014;33:1072–1076. © 2014 SETAC
Chemical composition, antioxidant, antimicrobial and cytotoxic activities of Tagetes minuta and Ocimum basilicum essential oils
Authors: Shirazi Mohsen Taheri , Gholami Hamid , Kavoosi Gholamreza , Rowshan Vahid , Tafsiry Asad 
Published: January 2014

AbstractChemical composition, antioxidant, antimicrobial and cytotoxic activities of Tagetes minuta (TM) essential oil (TMO) and Ocimum basilicum (OB) essential oil (OBO) were examined. The main components for TMO were dihydrotagetone (33.9%), E‐ocimene (19.9%), tagetone (16.1%), cis‐β‐ocimene (7.9%), Z‐ocimene (5.3%), limonene (3.1%) and epoxyocimene (2.03%). The main components for OBO were methylchavicol (46.9%), geranial (19.1%), neral (15.15%), geraniol (3.0%), nerol (3.0%), caryophyllene (2.4%). Inhibitory concentrations (IC50) for reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavenging were 12–17 and 200–250 μg/mL of TMO and OBO, respectively. Minimal inhibitory concentration (MIC) against Salmonella typhi, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Aspergillus niger, and Candida albicans were 150 ± 8, 165 ± 9, 67 ± 8, 75 ± 7, 135 ± 15, and 115 ± 8 μg/mL of TMO, respectively. MIC for S. typhi, E. coli, S. aureus, B. subtilis, A. niger, and C. albicans were 145 ± 8, 160 ± 7, 45 ± 4, 40 ± 3, 80 ± 9, and 95 ± 7 μg/mL of OBO, respectively. IC50 for nasopharyngeal cancer cell line (KB) and liver hepatocellular carcinoma cell line (HepG2) were 75 ± 5 and 70 ± 4 μg/mL of TMO, respectively. IC50 for KB and HepG2 were 45 ± 4 and 40 ± 3 μg/mL of OBO, respectively. Thus, they could be used as an effective source of natural antioxidant and antibacterial additive to protect foods from oxidative damages and foodborne pathogens. Furthermore, they could be promising candidate for antitumor drug design.
Testing Gene–Gene Interactions in Genome Wide Association Studies
Authors: Hu Jie Kate , Wang Xianlong , Wang Pei 
Published: January 2014

ABSTRACTDetection of gene–gene interaction has become increasingly popular over the past decade in genome wide association studies (GWAS). Besides traditional logistic regression analysis for detecting interactions between two markers, new methods have been developed in recent years such as comparing linkage disequilibrium (LD) in case and control groups. All these methods form the building blocks of most screening strategies for disease susceptibility loci in GWAS. In this paper, we are interested in comparing the competing methods and providing practical guidelines for selecting appropriate testing methods for interaction in GWAS. We first review a series of existing statistical methods to detect interactions, and then examine different definitions of interactions to gain insight into the theoretical relationship between the existing testing methods. Lastly, we perform extensive simulations to compare powers of various methods to detect either interaction between two markers at two unlinked loci or the overall association allowing for both interaction and main effects. This investigation reveals informative characteristics of various methods that are helpful to GWAS investigators.