bluuebunny/crossref_metadata_2025_split huggingface dataset:
Performance Comparison of Different Separation Systems for H2 Recovery from Catalytic Reforming Unit Off‐Gas Streams
Authors: Mivechian A. , Pakizeh M. 
Published: February 2013

AbstractThe performance of pressure swing adsorption (PSA), membrane separation, and gas absorption systems for H2 recovery from refinery off‐gas stream was studied by simulation‐based data. The PSA process was simulated using adsorbents of silica gel and activated carbon for removing heavy and light hydrocarbons. The mole fraction profiles of all components and the relationship between hydrogen purity and recovery as a function of feed pressure were examined. The solution‐diffusion model was applied for modeling and simulation of a one‐stage membrane process. The gas absorption process with a tower tray was simulated at sub‐zero temperature and the correlation between hydrogen purity and recovery as a function of tower pressure and temperature was evaluated at different solvent flow rates.
Optimization of Oxygen Transfer through Membrane Diffusers for Biological Sweetening of Biogas
Authors: Rodriguez G. , Dorado A. D. , Bonsfills A. , Gabriel D. , Gamisans X. 
Published: February 2013

AbstractBiological techniques for the removal of gaseous pollutants such as hydrogen sulfide (H2S) have proved to be effective, environmentally friendly, and economically viable. However, when high concentrations of H2S are treated, the process is severely restricted by the oxygen deficit in the liquid phase. The oxygen transfer efficiency provided by a membrane diffuser is evaluated under typical pressure and salinity conditions used for the biological treatment of H2S in biogas. The optimal operating parameters for enhanced oxygen transfer were determined. The addition of pure oxygen with a membrane diffuser to increase the oxygen transfer rate and the use of a nonaqueous phase to improve oxygen transfer in a bioscrubber system are also evaluated.
D‐optimal minimax fractional factorial designs
Authors: Lin Dennis K. J. , Zhou Julie 
Published: February 2013

AbstractThe D‐optimal minimax criterion is proposed to construct fractional factorial designs. The resulting designs are very efficient, and robust against misspecification of the effects in the linear model. The criterion was first proposed by Wilmut & Zhou (2011); their work is limited to two‐level factorial designs, however. In this paper we extend this criterion to designs with factors having any levels (including mixed levels) and explore several important properties of this criterion. Theoretical results are obtained for construction of fractional factorial designs in general. This minimax criterion is not only scale invariant, but also invariant under level permutations. Moreover, it can be applied to any run size. This is an advantage over some other existing criteria. The Canadian Journal of Statistics 41: 325–340; 2013 © 2013 Statistical Society of Canada
The impact of having a sister diagnosed with breast cancer on cancer‐related distress and breast cancer risk perception
Authors: Metcalfe Kelly A. , Quan May‐Lynn , Eisen Andrea , Cil Tulin , Sun Ping , Narod Steven A. 
Published: February 2013

AbstractBACKGROUND:A family history of breast cancer has been shown to affect psychosocial functioning. However, the majority of research has focused on the daughters of patients with breast cancer and families with multiple relatives with the disease. The purpose of the current study was to examine cancer‐related distress and breast cancer risk perception, and further examine the predictors of these outcomes, in the sisters of newly diagnosed patients with breast cancer without a previous family history of the disease.METHODS:Sisters of newly diagnosed index breast cancer patients were identified and asked to complete a study‐specific questionnaire (demographics and cancer risk perception) and the Impact of Events Scale. Pathological information was abstracted from the medical chart for the index breast cancer patients.RESULTS:A total of 205 sisters completed the questionnaires. The mean time between breast cancer diagnosis and the sisters' completion of the questionnaire was 9.8 months. Approximately one‐half of the women scored in the moderate or severe distress range. The most significant predictor of cancer‐related distress was perceived lifetime breast cancer risk (P = .04). Women with a lifetime risk of breast cancer > 20% were more than twice as likely to have moderate or severe distress compared with those with a lifetime risk of < 20%.CONCLUSIONS:Cancer‐related distress is high in the sisters of newly diagnosed patients with breast cancer in whom there is no other family history of breast cancer. Specifically, women with a perceived lifetime risk of breast cancer of > 20% experienced the highest levels of distress. Future interventions that target this group should be considered. Cancer 2013. © 2013 American Cancer Society.
The impact of radiation therapy sequencing on survival and cardiopulmonary mortality in the combined modality treatment of patients with esophageal cancer
Authors: Wojcieszynski Andrzej P. , Berman Abigail T. , Wan Fei , Plastaras John P. , Metz James M. , Mitra Nandita , Apisarnthanarax Smith 
Published: February 2013

BACKGROUNDThe addition of chemoradiation (CRT) to surgery has been shown to improve survival in patients with esophageal cancer. In the current study, the authors determined whether the sequencing of CRT has an effect on survival and cardiopulmonary mortality in patients with esophageal cancer.METHODSPatients with the following inclusion criteria were identified within 17 Surveillance, Epidemiology, and End Results registries from 1988 through 2007: adenocarcinoma or squamous cell carcinoma of the esophagus and having undergone esophagectomy. Patients who died within 90 days of surgery were excluded. Demographic, tumor, and survival data were compared between patients receiving preoperative and postoperative RT. Cox proportional hazards regression models were calculated to identify parameters associated with cause‐specific survival and overall survival. A competing risk analysis was performed to account for death due to esophageal cancer in the calculation of cardiopulmonary mortality.RESULTSOf 5512 patients, 1881 received preoperative RT, 901 received postoperative RT, and 2730 did not receive RT. Patients receiving preoperative RT had improved 5‐year cause‐specific survival (41% vs 31%; P < .0001) and overall survival (33% vs 23%; P < .0001) compared with those receiving postoperative RT. No differences in adjusted cardiopulmonary mortality were found between patients who received RT versus those who did not (8% vs 10% at 10 years; hazards ratio [HR], 0.84 [95% confidence interval (95% CI), 0.64‐1.12] [P = .24]) or between those treated with preoperative RT versus those treated with postoperative RT (HR, 0.70; 95% CI, 0.46‐1.08 [P = .11]).CONCLUSIONSThese population‐based data support the use of preoperative RT in patients with locally advanced esophageal cancer. RT should not be withheld out of concern for cardiopulmonary mortality. Cancer 2013;119:1976–1984. © 2013 American Cancer Society.
Antidepressant use and new‐onset diabetes: a systematic review and meta‐analysis
Authors: Bhattacharjee Sandipan , Bhattacharya Rituparna , Kelley George A. , Sambamoorthi Usha 
Published: February 2013

SummaryAntidepressant use has been linked to new‐onset diabetes. However, the existing literature on this relationship has yielded inconsistent findings. The primary objective of this study was to systematically synthesize the literature on the relationship between antidepressant use and new‐onset diabetes using meta‐analysis.A systematic literature search was conducted to identify relevant studies in seven electronic databases. Two independent reviewers identified the final list of studies to be included in the meta‐analysis using a priori selection criteria. Results for the primary outcome of interest, that is, odds and hazards of developing new‐onset diabetes, were pooled using a random‐effects model. Egger's regression test and the Trim and Fill method were utilized to detect the presence of any potential publication bias. Sensitivity analysis was conducted using the leave‐one‐out method as well as individual categories of antidepressant drugs.Eight studies met the inclusion criteria. Random effects models revealed that adults with any use of antidepressants were more likely to develop new‐onset diabetes compared with those without any use of antidepressants [odd ratios = 1.50, 95% confidence interval (CI), 1.08–2.10; hazards ratio = 1.19, 95% CI, 1.08–1.32]. Sensitivity analyses revealed fair robustness; selective serotonin reuptake inhibitors and tricyclic antidepressants were more likely to be associated with the development of new‐onset diabetes. Results from the Egger's regression test and Trim and Fill method revealed no evidence of publication bias.Among adults, antidepressant use was associated with higher chances of new‐onset diabetes. However, because a cause‐and‐effect relationship cannot be established by observational studies, future randomized controlled studies are needed to confirm this association. Copyright © 2013 John Wiley & Sons, Ltd.
Common mechanisms of dysfunctional adipose tissue and obesity‐related cancers
Authors: Matafome P. , Santos‐Silva D. , Sena C. M. , Seiça R. 
Published: February 2013

SummaryThe relation between cancer and metabolic disorders was recognized several decades ago, but the underlying mechanisms involved in cancer development and progression remain obscure. In the last years, many groups have been studying systemic adipose tissue markers in cancer patients. However, few consistent results were obtained. On the other hand, several studies revealed many aspects of adipose tissue physiology in obesity. Nowadays, it is recognized that excessive lipid uptake in adipocytes leads to hypertrophy and consequently to metabolic dysregulation, hypoxia, inflammation, impaired adipocytokine expression and angiogenesis, insulin resistance and macrophage recruitment. In obese patients, tumours commonly colocalize with excessive adipose tissue accumulation, and most of the features of hypertrophic adipose tissue are observed in cancer patients, namely breast and colon. This review aimed to summarize pathological adipose tissue alterations that may contribute to cancer aetiology and development. Copyright © 2013 John Wiley & Sons, Ltd.
Zinc transporter 8 autoantibody (ZnT8A) could help differentiate latent autoimmune diabetes in adults (LADA) from phenotypic type 2 diabetes mellitus
Authors: Huang Gan , Xiang Yufei , Pan Lingling , Li Xia , Luo Shuoming , Zhou Zhiguang 
Published: February 2013

AbstractBackgroundThe ZnT8A is an independent marker for diagnosis of type 1 diabetes mellitus. We investigated the distribution and clinical features of ZnT8A positive latent autoimmune diabetes in adult (LADA) patients to explore the potential diagnostic application.MethodsA total of 3062 phenotypic T2DM patients were randomly selected from a national multicenter study – the LADA China Study. Radioligand binding assays were applied to detect the presence of ZnT8A, GADA and IA‐2A. HbA1c, fasting C‐peptide and serum lipid levels were followed up with ZnT8A positive patients.ResultsThe positive prevalence of ZnT8A, GADA and IA‐2A in phenotypic T2DM patients was 1.99%(61/3062), 6.43% (197/3062) and 1.96% (60/3062), respectively. The ZnT8A positivity was lower than that of GADA(x2 = 74.8, p < 0.001) but was comparable with that of IA‐2A(p > 0.05). The positivity of ZnT8A in IA‐2A positive patients was higher than that in GADA positive patients(38.3% vs. 10.7%, x2 = 24.8, p < 0.001). On the basis of GADA and IA‐2A positivity, the ZnT8A assay enhanced the diagnostic prevalence of LADA from 7.58 to 8.62%. The LADA patients who were positive for ZnT8A had higher systolic blood pressure when compared with GADA positive cases(p = 0.049) and higher total cholesterol levels when compared with antibody‐negative T2DM patients(p = 0.035).ConclusionThe detection of ZnT8A at the basis of GADA and IA‐2A can improve diagnostic sensitivity of Chinese LADA. Copyright © 2013 John Wiley & Sons, Ltd.
Both autologous bone marrow mononuclear cell and peripheral blood progenitor cell therapies similarly improve ischaemia in patients with diabetic foot in comparison with control treatment
Authors: Dubsky M. , Jirkovska A. , Bem R. , Fejfarova V. , Pagacova L. , Sixta B. , Varga M. , Langkramer S. , Sykova E. , Jude E. B. 
Published: February 2013

AbstractBackgroundThe aim of our study was to compare the effect of bone marrow mononuclear cell and peripheral blood progenitor cell therapies in patients with diabetic foot disease and critical limb ischaemia unresponsive to revascularization with conservative therapy.MethodsTwenty‐eight patients with diabetic foot disease (17 treated by bone marrow cells and 11 by peripheral blood cell) were included into an active group and 22 patients into a control group without cell treatment. Transcutaneous oxygen pressure and rate of major amputation, as the main outcome measures, were compared between bone marrow cells, peripheral blood cell and control groups over 6 months; both cell therapy methods were also compared by the characteristics of cell suspensions. Possible adverse events were evaluated by changes of serum levels of angiogenic cytokines and retinal fundoscopic examination.ResultsThe transcutaneous oxygen pressure increased significantly (p < 0.05) compared with baseline in both active groups after 6 months, with no significant differences between bone marrow cells and peripheral blood cell groups; however, no change of transcutaneous oxygen pressure in the control group was observed. The rate of major amputation by 6 months was significantly lower in the active cell therapy group compared with that in the control group (11.1% vs. 50%, p = 0.0032), with no difference between bone marrow cells and peripheral blood cell. A number of injected CD34+ cells and serum levels of angiogenic cytokines after treatment did not significantly differ between bone marrow cells and peripheral blood cell.ConclusionsOur study showed a superior benefit of bone marrow cells and peripheral blood cell treatments of critical limb ischaemia in patients with diabetic foot disease when compared with conservative therapy. There was no difference between both cell therapy groups, and no patient demonstrated signs of systemic vasculogenesis. Copyright © 2013 John Wiley & Sons, Ltd.
Unexpected One‐Electron Oxidation of a Secondary Phosphite Selenide Cp(CO)2FeP(Se)(OiPr)2 by GaCl3 and InCl3 – Rare Examples of Di‐ and Triselenide Formation
Authors: Kuimov Vladimir A. , Liao Ping‐Kuei , Chiou Ling‐Song , You Hong‐Chih , Fang Ching‐Shiang , Liu C. W. 
Published: February 2013

AbstractThe reactions of the neutral phosphonoselenoate [Cp(CO)2FeP(Se)(OiPr)2] (1) with Lewis acids (GaCl3, InCl3) produce dicationic complexes [{Cp(CO)2FeP(OiPr)2}2Sen][GaCl4]2, [n = 2 (2), 3 (3)] and [{Cp(CO)2FeP(OiPr)2}2Sen][InCl4]2 [n = 2 (4), 3 (5)] in good yields; the complexes comprise an Se3 (or Se2) chain that bridges two FpP(OiPr)2 groups [Fp = Cp(CO)2Fe]. These compounds are the one‐electron oxidation products of secondary phosphite selenide 1 by group 13 (Ga, In) trichlorides. On the other hand, the reaction of GaCl3 with (iPrO)2PSe2– (dsep) yields only the Lewis adduct tris(O,O‐diisopropyldiselenophosphate)gallium (6). The 31P NMR spectrum of 6 at 183 K reveals that the gallium(III) center is surrounded by one chelating and two pendant dsep ligands, which is in line with the obtained X‐ray structure. In addition, the two‐electron oxidation of 1 leads to phosphite [Cp(CO)2FeP(O)(OiPr)2] formation.
Cage Metal Complexes: Synthesis, X‐ray Structure, and Spectral and Redox Behavior of the First Hybrid Iron(II) Clathrochelatoscorpionate and Its Pyrazoloxime‐Armed Macrocyclic Intermediate
Authors: Varzatskii Oleg A. , Kats (Menkach) Svitlana V. , Penkova Larysa V. , Volkov Sergey V. , Dolganov Alexander V. , Vologzhanina Anna V. , Bubnov Yurii N. , Voloshin Yan Z. 
Published: February 2013

AbstractCycloaddition of a new pyrazoloxime to macrocyclic iron(II) bis(α‐benzyldioximate) unexpectedly gave a mixture of the first hybrid clathrochelatoscorpionate and its pyrazoloxime‐armed macrocyclic intermediate, which were characterized by X‐ray crystallography, spectroscopy, and cyclic voltammetry.
Synthesis of Isoxazoline Derivatives through Boulton–Katritzky Rearrangement of 1,2,4‐Oxadiazoles
Authors: Palumbo Piccionello Antonio , Guarcello Annalisa , Pace Andrea , Buscemi Silvestre 
Published: February 2013

AbstractThe base‐induced rearrangement of 1,2,4‐oxadiazoles into isoxazoline derivatives is reported. This represents the first example of a three‐atom side‐chain rearrangement that involves a saturated CCO side chain at C‐3 of the oxadiazole. Nonaromatic 3‐amino‐isoxazoline derivatives are obtained in good yields. Interestingly, this reaction occurs through the rearrangement of aromatic oxadiazoles to form less stable bonds than those that are broken.
On simulations investigating droplet diameter–charge distributions in electrostatically atomized dielectric liquid sprays
Authors: Amine‐Eddine G. H. , Shrimpton J. S. 
Published: February 2013

SUMMARYA general procedure has been developed for the simulation of charged liquid and electrostatically atomized sprays. The procedure follows a Lagrangian approach for simulation of spray droplets and a Eulerian approach for gas‐phase variables, including the electric field generated by the charge presence on droplets. Validation of the procedure was examined through simulations of previously published charged spray experiments. Results showed that for the specification of initial droplet charge, modelling the droplet charge–diameter relationship through a scaling law is as reliable a method as using a directly obtained charge–diameter relationship from experimental measurements. The normalized root‐mean‐square errors for sprays using the two methods were shown to be within 12% of one another, for the prediction of spatially averaged profiles of mean droplet diameters, mean axial velocities and mean radial droplet velocities. Results showed that the general spatial characteristics and dynamics of a charged liquid spray can successfully be reproduced, including the axial and radial dispersal pattern of droplets and the distribution of mean droplet diameters throughout the spray plume. For all sprays with droplet charges defined through a scaling law relationship, the normalized root‐mean‐square errors range from 9.0% to 31.6% for mean droplet diameters, 10.4% to 67.9% for mean axial droplet velocities and 16.8% to 38.6% for mean radial droplet velocities. Lastly, we present a brief set of general recommendations for simulating electrostatically atomized dielectric liquid sprays.Copyright © 2013 John Wiley & Sons, Ltd.
Hafnium isotope fractionation during continental weathering: Implications for the generation of the seawater Nd‐Hf isotope relationships
Authors: Chen Tian‐Yu , Li Gaojun , Frank Martin , Ling Hong‐Fei 
Published: February 2013

AbstractTo investigate the mechanisms of the offset of seawater radiogenic Nd‐Hf isotope compositions from those of the upper continental crust rocks, combined Nd‐Hf isotope compositions of desert and loess samples from northern China (which integrate a wide range of lithologies and ages of continental rocks) are presented in this study. The results show significant and systematic fractionation of Hf isotopes between fine‐grained detritals/leachates (<5 µm) and coarser fractions (<75 µm) of the same samples. A small but systematic difference of Nd isotope compositions between leachates and detrital silicates is also revealed. Overall, the leaching data either plot along or slightly above the Nd‐Hf seawater array, providing strong direct support that the seawater Nd‐Hf isotope relationship is predominantly generated by weathering of upper continental crust. Our study supports the application of dissolved Hf isotopes as a proxy for different modes of weathering regimes rather than for continental source provenances.
A CONSISTENT DECOMPOSITION OF THE REDISTRIBUTIVE, VERTICAL, AND HORIZONTAL EFFECTS OF HEALTH CARE FINANCE BY FACTOR COMPONENTS
Authors: Hierro Luis A. , Gómez‐Álvarez Rosario , Atienza Pedro 
Published: February 2013

SUMMARYIn studies on the redistributive, vertical, and horizontal effects of health care financing, the sum of the contributions calculated for each financial instrument does not equal the total effects. As a consequence, the final calculations tend to be overestimated or underestimated. The solution proposed here involves the adaptation of the Shapley value to achieve additive results for all the effects and reveals the relative contributions of different instruments to the change of whole‐system equity. An understanding of this change would help policy makers attain equitable health care financing. We test the method with the public finance and private payments of health care systems in Denmark and the Netherlands. Copyright © 2013 John Wiley & Sons, Ltd.
Role of procoagulant microparticles in mediating complications and outcome of acute liver injury/acute liver failure
Authors: Stravitz Todd R. , Bowling Regina , Bradford Robert L. , Key Nigel S. , Glover Sam , Thacker Leroy R. , Gabriel Don A. 
Published: February 2013

Abstract

Microparticles (MPs), membrane fragments of 0.1-1.0 μm, are derived from many cell types in response to systemic inflammation. Acute liver failure (ALF) is a prototypical syndrome of systemic inflammatory response syndrome (SIRS) associated with a procoagulant state. We hypothesized that patients with ALF develop increased procoagulant MPs in proportion to the severity of systemic complications and adverse outcome. Fifty patients with acute liver injury (ALI), 78% of whom also had hepatic encephalopathy (HE; ALF), were followed until day 21 after admission. MPs were characterized by Invitrox Sizing, Antigen Detection and Enumeration, a light-scattering technology that can enumerate MPs as small as 0.15 μm, and by flow cytometry. Procoagulant activity was assessed by a functional MP-tissue factor (MP-TF) assay. Sixteen patients (32%) died and 27 (54%) recovered without liver transplantation (LT). Total MPs (0.15-1.0 μm) were present in nearly 19-fold higher concentrations in ALI/ALF patients, compared to healthy controls (P < 0.0001). MP-TF assays revealed high procoagulant activity (9.05 ± 8.82 versus 0.24 ± 0.14 pg/mL in controls; P = 0.0008). MP concentrations (0.28-0.64 μm) were higher in patients with the SIRS and high-grade HE, and MPs in the 0.36-0.64-μm size range increased in direct proportion to SIRS severity (P < 0.001) and grade of HE (P < 0.002). Day 1 MPs (0.28-0.64 μm) correlated with laboratory predictors of death/LT (higher phosphate and creatinine; lower bicarbonate), and day 1 and 3 MPs were higher in patients who died or underwent LT, compared to spontaneous survivors (P ≤ 0.01). By flow cytometry, 87% of patients had circulating CD41+ MPs, indicating platelet origin. Conclusion: Highly procoagulant MPs of specific size ranges are associated with the SIRS, systemic complications, and adverse outcome of ALI/ALF. MPs may contribute to the multiorgan system failure and high mortality of ALF. (HEPATOLOGY 2013;)