bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of murine post-pneumonectomy lung regeneration by 18FDG PET imaging
Authors: Gibney Barry C , Park Mi-Ae , Chamoto Kenji , Ysasi Alexandra , Konerding Moritz A , Tsuda Akira , Mentzer Steven J 
Published: November 2012

Abstract

Background
An intriguing biologic process in most adult mammals is post-pneumonectomy lung regeneration, that is, the removal of one lung (pneumonectomy) results in the rapid compensatory growth of the remaining lung. The spatial dependence and metabolic activity of the rodent lung during compensatory lung regeneration is largely unknown.

Methods
To determine if murine lung regeneration could be detected in vivo, we studied inbred mice 3, 7, 14, and 21 days after left pneumonectomy. The remaining lung was imaged using microCT as well as the glucose tracer 2-deoxy-2-[18 F]fluoro-d-glucose (18FDG) and positron-emission tomography (PET). Because of the compliance of the murine chest wall, reproducible imaging required orotracheal intubation and pressure-controlled ventilation during scanning.

Results
After left pneumonectomy, the right lung progressively enlarged over the first 3 weeks. The cardiac lobe demonstrated the greatest percentage increase in size. Dry weights of the individual lobes largely mirrored the increase in lung volume. PET/CT imaging was used to identify enhanced metabolic activity within the individual lobes. In the cardiac lobe, 18FDG uptake was significantly increased in the day 14 cardiac lobe relative to preoperative values (p < .05). In contrast, the 18FDG uptake in the other three lobes was not statistically significant at any time point.

Conclusions
We conclude that the cardiac lobe is the dominant contributor to compensatory growth after murine pneumonectomy. Further, PET/CT scanning can detect both the volumetric increase and the metabolic changes associated with the regenerative growth in the murine cardiac lobe.
Multimodality in Design of Tangible Systems
Authors: Tellioğlu Hilda , Ehrenstrasser Lisa , Spreicer Wolfgang 
Published: November 2012

Abstract
In this paper we present how we applied and analyzed multimodality in design of tangible communication systems for elderly. First we define six categories of multimodality (aural, visual, tactile, gesture, posture, and space), which we integrate in our design processes and design artifacts. We illustrate how user interaction has been established, especially when multimodality is central to our approach. We also discuss multimodal design in context of user experiences, user-centered design, and participatory design approaches. We show the added value and change of focus through multimodality in design processes. We analyze our findings before we conclude our paper.
Fostering Social Interaction in AAL: Methodological reflections on the coupling of real household Living Lab and SmartHome approaches
Authors: Budweg Steffen , Lewkowicz Myriam , Müller Claudia , Schering Sandra 
Published: November 2012

Abstract
For user-centred design of ICT solutions in the AAL field, an approach combining real household living lab and SmartHome lab seems promising. Based on our experiences within the AAL project FoSIBLE, we propose a mixed-method approach to develop and evaluate a Social TV system from both a bird′s eye and worm′s-eye perspective in regards to user acceptance and rejection. We provide insights into the methodological strategies and analyse the strengths and weaknesses of our proposition to demonstrate how the different methodological approaches can augment each other in the different phases of AAL projects.
Automatisierte nichtinvasive Emotionsmessung. Ein Erfahrungsbericht von der Vision bis zur Realisierung
Authors: Gerber Paul , Ullrich Daniel 
Published: November 2012

Zusammenfassung
Affektive Reaktionen spielen eine wichtige Rolle in der Usability- und User Experience Forschung und sind häufig Gegens-tand in entsprechenden Messinstrumenten. Diese Messinstrumente haben aber oft den Nachteil, dass sie den Interaktions-prozess unterbrechen, etwa wenn sie während eines Usability-Tests durchgeführt werden. Oder aber sie unterliegen retro-spektiven Verfälschungen, zum Beispiel wenn sie nach Abschluss der Interaktion durchgeführt werden. Ziel unserer Arbeit war die Entwicklung eines nichtinvasiven Messinstruments, das emotionale Reaktionen während einer Interaktion erfassbar macht, ohne dass der Interaktionsprozess unterbrochen werden müsste. In dem vorliegenden Beitrag skizzieren wir den Prozess der Entwicklung dieses Messinstruments, von der ursprünglichen Vision bis zur Realisierung. Dabei gehen wir auf theoretische wie praktische Hindernisse ein und beschreiben, wie diese die finale Lösung beeinflusst haben. Abschließend berichten wir Ergebnisse zur Genauigkeit aus der Pilotstudie und diskutieren Implikationen für zukünftige Arbeiten sowie für Praktiker, die solch ein System einsetzen möchten.
Der Newbie, der Fortgeschrittene und der Power-User. Warum es nicht reicht, “einfach mal die Nutzer zu fragen”
Authors: Heckner Markus , Schneidermeier Tim , Hastreiter Isabella , Wolff Christian 
Published: November 2012

Zusammenfassung
Innerbetriebliche Software entwickelt sich häufig über Jahre hinweg inkrementell weiter, sammelt so Schritt für Schritt Funktionen an und verliert an Übersichtlichkeit. Soll diese Software hinsichtlich ihrer Gebrauchstauglichkeit optimiert werden, müssen aus Sicht eines externen Usability-Beraters zunächst die Domäne des Kunden verstanden und die Arbeitsprozesse analysiert werden. In der Analyse muss insbesondere der Umgang unterschiedlicher Nutzergruppen mit der Software berücksichtigt werden, um fundierte Neuvorschläge in einem Redesign erarbeiten zu können. In diesem Erfahrungsbericht beschreiben wir anhand eines konkreten Praxisbeispiels Eigenschaften von Nutzergruppen und deren Einfluss auf die Analyse, und warum es nicht reicht, die Nutzer “einfach mal zu fragen, wie sie die Software denn finden”.
Symmetric M-theory backgrounds
Authors: Figueroa-O’Farrill José 
Published: November 2012

AbstractWe classify symmetric backgrounds of eleven-dimensional supergravity up to local isometry. In other words, we classify triples (M, g, F), where (M,g) is an eleven-dimensional lorentzian locally symmetric space and F is an invariant 4-form, satisfying the equations of motion of eleven-dimensional supergravity. The possible (M,g) are given either by (not necessarily nondegenerate) Cahen-Wallach spaces or by products AdSd × M11−d for 2 ⩽ d ⩽ 7 and M11−d a not necessarily irreducible riemannian symmetric space. In most cases we determine the corresponding F-moduli spaces.
RAPD polymorphism in the prebreeding material for cultivation of synthetic variations of lucerne (Medicago sativa L.)
Authors: Skuza Lidia , Rogalska Stanisława , Dyba Stanisław , Bocianowski Jan 
Published: November 2012

AbstractGenetic diversity between synthetic cultivars (Syn5, Syn7), inbred lines (D3, D5, E1/2, G1/1, G1/2) and ecotypes (E16, E51, E182, E231) of lucerne (Medicago sativa L.) was studied using the RAPD-PCR method. The plants differed in the efficiency of seed set and in the yield of green mass. The ecotypes E182 and E231 and the synthetic population Syn5 showed the highest fertility. Additionally, Syn5 also showed the highest efficiency of seed set and the yield of green mass. Among the inbred lines, D3 was characterised by the highest yield of green mass and E1/2 by the highest fertility. An optimal combination of yield and biomass was observed for the synthetic population Syn5, obtained by crossing the lines D3, D5 and G1/1, as demonstrated using comparative analysis. A total of 338 polymorphic products were generated using 20 arbitrary primers. Cluster analysis using the Unweighted-Pair Group Method with Arithmetic Mean (UPGMA) in the Molecular image Gel Doc™ XR (Bio-Rad) software based on the Dice’s coefficient of genetic similarity showed a division of the studied forms into two groups based on genetic similarity. The ecotype E16 formed one of the groups whereas all of the other ecotypes observed in this study clustered into the second group. A high level of polymorphism among the studied lucerne forms was detected indicating an interesting gene pool awaiting future exploration. Analysis of variance also supported a high diversity among the studied forms. This study provides insightful information into the heterosis effect of synthetic populations or hybrids of F1 lucerine by providing correlations between the genetic background of the inbred lines and their ability to produce a specific yield.
Autumn-winter diet overlap of fallow, red, and roe deer in forest ecosystems, Southern Poland
Authors: Obidziński Artur , Kiełtyk Piotr , Borkowski Jakub , Bolibok Leszek , Remuszko Karolina 
Published: November 2012

AbstractThe wild population of fallow deer in Central Europe has grown considerably over the last decade. However, information on feeding habits of this alien species in relation to the indigenous red deer or roe deer, in areas of their co-occurrence, is scarce. A prevailing view maintains that their food-niches are distinct, although direct comparative studies have not been carried out. Therefore, the aim of the research was to compare the diets of fallow, red, and roe deer feeding in the same habitat. Research was based on the rumen contents of 242 animals hunted in the autumn-winter season in the forests of Southern Poland. The analyses demonstrated that fallow deer are moderate grazers in such conditions and eat more graminoids in comparison to red or roe deer (36.4% vs. 16.1% or 5.5%, respectively). On the other hand, it feeds on less browse (17.2% vs. 41.4%) or dwarf shrubs (8.4% vs. 19.0%) than red deer, and on less bramble (10.9% vs. 34.6%) or forbs (4.0% vs. 7.6%) in comparison to roe deer (P=0.05). Although the diets of the three deer species differ in terms of the proportion of each food type in their diet, overlapping of their food-niches is high (52.6%).
Comparison of signal peptides for efficient protein secretion in the baculovirus-silkworm system
Authors: Soejima Yasuhiko , Lee Jae , Nagata Yudai , Mon Hiroaki , Iiyama Kazuhiro , Kitano Hajime , Matsuyama Michiya , Kusakabe Takahiro 
Published: November 2012

AbstractThe baculovirus-silkworm expression system is widely used as a mass production system for recombinant secretory proteins. However, the final yields of some recombinant proteins are not sufficient for industrial use. In this study, we focused on the signal peptide as a key factor for improving the efficiency of protein production. Endoplasmic reticulum (ER) translocation of newly synthesized proteins is the first stage of the secretion pathway; therefore, the selection of an efficient signal peptide would lead to the efficient secretion of recombinant proteins. The Drosophila Bip and honeybee melittin signal peptides have often been used in this system, but to the best of our knowledge, there has been no study comparing secretion efficiency between exogenous and endogenous signal peptides. In this study we employed signal peptides from 30K Da and SP2 proteins as endogenous signals, and compared secretion efficiency with those of exogenous or synthetic origins. We have found that the endogenous secretory signal from the 30K Da protein is the most efficient for recombinant secretory protein production in the baculovirus-silkworm expression system.
Self-organization of polyaniline during oxidative polymerization: formation of granular structure
Authors: Shishov Mikhail , Moshnikov Vyacheslav , Sapurina Irina 
Published: November 2012

AbstractThe paper is focused on oxidative polymerization of aniline proceeding in an acid medium with a strong oxidant; formation of polyaniline (PANI) granular structures in different steps of the synthesis was studied. The relationship between the processes of self-organization of the growing polymer into supramolecular structures and the steps of molecular synthesis has been revealed. It was shown that during the induction period (the initial synthesis step), insoluble non-conducting products are formed. They are characterized by the absorption band at 430 nm corresponding to the wavelength of the phenazinium cation radical peak. In the second step, the polymer chain growth, conducting PANI granules with the diameter of 50 nm were obtained. These granules consist of spherical particles with the diameter as small as several nanometers. Then, the granule dimensions increased to 200 nm due to the growth of the spheres; the sphere diameter reached 20 nm. The number of spheres in a granule remained constant. Both precipitate and PANI film consist of common structural elements, polymer spheres, organized into granules and larger structures. Suppression of the polymer chain growth leads to the formation of non-conducting aniline oligomers which are self-organized into large particles with fractal structure. To describe the self-organization processes of a growing polymer chain, the diffusion-limited aggregation mechanism was used.
Facile synthesis of ultrafine TiO2 nanowires with large aspect ratio and its photoactivity
Authors: Anjusree G. S. , Asha A. M. , Subramanian K. R. V. , Sivakumar N. , Nair A. Sreekumaran , Nair Shantikumar V. , Balakrishnan Avinash 
Published: November 2012

Abstract
In the present study, ultrafine TiO2 nanowires (∼80 nm in diameter) exhibiting large aspect ratio in the order of 103 were synthesized hydrothermally. Phase and morphological analysis of the nanowires was carried out using X-ray diffractometry, X-ray photoelectron spectroscopy and scanning electron microscopy. High resolution transmission electron microscopy revealed the wire exhibiting growth in (101). A Tauc plot derived from UV analysis showed the average band gap values for nanowires to be less than for nanoparticles of similar diameter. It was observed that nanowires exhibited a high degree of photoactivity in an eosin-based dye system which was found to be 20 – 30 % more than that of nanoparticles. This high photoactivity in nanowires was attributed to the longer charge retention which was observed during lifetime measurements, resulting in easy radical formation and dye degradation. Lifetime measurements on the nanowires showed the recombination time to be 54 ns as compared to 43 ns for nanoparticles.
Age-hardenability related to precipitation and lamellar-forming grain boundary reaction in dental low-carat gold alloy
Authors: Kim Young-Oh , Kim Hyung-Il , Cho Mi-Hyang , Cho Su-Yoen , Lee Gwang-Young , Kwon Yong Hoon , Seol Hyo-Joung 
Published: November 2012

Abstract
A dental Ag–Au–Cu–Pd alloy with small amounts of Zn and Ir was examined to determine the association of the age-hardenability with the phase transformation process and microstructural changes by means of hardness testing, X-ray diffraction study, field emission scanning electron microscopic observation and energy dispersive spectrometry. The fast and apparent age-hardenability of the present alloy was possibly attributed to phase separation by spinodal decomposition and the formation of a fine and coherent cuboidal structure composed of the Ag–Au-rich α1 phase and the metastable Cu–Au-rich α2′ phase. The lamellar-forming grain boundary reaction was induced by internal strain before the maximum hardness value was obtained. Moreover, growth of the grain boundary lamellar structure toward the grain interior and its coarsening acted as a strain-releasing softening mechanism, which caused a decrease in age-hardenability. A change in Ag and Pd content might alter the start point of lamellar-formation and the age-hardenability of Ag–Au–Cu–Pd alloys.
Agreement between magnetic resonance imaging, myelography, and surgery for detecting recurrent, thoracolumbar intervertebral disc extrusion in dogs
Authors: Brisson B. A. , Nykamp S. G. , Reynolds D. 
Published: November 2012

SummaryObjectives: Although magnetic resonance imaging (MRI) is reported to be superior to myelography to determine the location and site of first time disc herniation, comparison of these diagnostic methods in cases of recurrent intervertebral disc disease (IVD) herniation after a first surgery has not been evaluated. The objective was to compare the diagnostic accuracy of MRI and myelography in a series of dogs undergoing repeat surgical decompression for recurrent IVD extrusion when compared to the gold standard of surgery.Methods: Ten dogs with recurrent IVD herniation underwent MRI and myelography followed by surgical decompression. Three observers reviewed the images to determine the site and side of the first surgery and the recurrent lesion. Agreement was determined by calculating a kappa (κ) score.Results: Substantial interobserver agreement was noted for recurrent lesion site using MRI and myelography (κ = 0.77 vs. 0.73) and when comparing MRI and myelography to the reported surgical site (κ = 0.73 vs. 0.67). Interobserver agreement was greater with MRI for circumferential location compared to myelography (κ = 0.76 vs. 0.43), similar to what was found when comparing to surgical side (κ = 0.82 vs. 0.49). The previous surgical site in this study had no effect on ability to identify the new lesion.Clinical significance: Despite the limitations of MRI, there was greater agreement between observers using MRI for both the recurrent and first lesion.
Quelques remarques sur « lalangue » et sur le cas particulier de la surdité prélinguale
Authors: Pellion Frédéric 
Published: November 2012

Résumé La forgerie par Jacques Lacan du néologisme « lalangue », au début des années 1970, marque sa prise de distance avec le modèle du langage jusque-là utilisé par lui. Toutefois, en face de la nouvelle expression, le lecteur de Lacan peut hésiter entre simple trait d’esprit ou nouveau concept, et ce d’autant que ses conséquences pour la clinique psychanalytique ne sont pas toujours développées par ce dernier. Après une présentation un peu ordonnée de sa (brève) histoire, on interrogera ici donc sa pertinence clinique en faisant le détour par un champ clinique très particulier où il semble pouvoir être utilement mis à contribution, à savoir le champ des incidences psychopathologiques de la surdité prélinguale.
Lacan et la langue anglaise
Authors: Cléro Jean-Pierre 
Published: November 2012

Résumé C’est une thèse indéfiniment rebattue jusqu’à satiété que, selon Lacan, « l’inconscient est structuré comme un langage » ; et sans doute faut-il entendre langage en un sens plus large que s’il était structuré comme une langue vernaculaire. Laquelle, d’ailleurs ? Mais le lecteur de Lacan ne peut manquer d’être surpris par le caractère sporadique, souvent équivoque, sibyllin, incertain, de ce qui est avancé çà et là sur les rapports de l’inconscient et de telle ou telle langue. C’est ainsi que la langue anglaise, qui partagerait cette caractéristique avec le japonais, est considérée comme opposant une résistance à l’inconscient et faisant obstacle à la psychanalyse. Certes le propos est loin d’être clair ; toutefois le travail d’élaboration est tenté plusieurs fois et l’œuvre de Lacan compte plus d’un linéament dans cette direction ; mais on est très loin d’une théorie en bonne et due forme, ce qui voue le chercheur à risquer des hypothèses et à ouvrir un champ de réflexions. Que ce soit par Freud ou par Lacan, le terrain des langues nous a été légué comme une affaire qui reste presque entièrement à instruire, en dépit de la thèse forte derrière laquelle elle se monte et dont elle paraît presque immédiatement dépendre : celle de la structuration de l’inconscient et du psychisme comme langage.
The scenario of presentation of young females in a rural cancer hospital of North India: An initial experience
Authors: Tiwari Vivek , Shukla Piyush , Gupta Gourav 
Published: November 2012

AbstractA total of 51 cases of young females aged between 18-35 years were prospectively studied for the presentation in a Rural Charitable Cancer hospital in north India during the period August 2011 to April 2012. Breast related symptoms comprised 27 (52.94%) cases, out of which 10 (19.60%) were proven malignant. Other cases seen were Gynecological (Gyn) 8 (15.68%), Head and Neck (H and N) 5 (9.80%), Gastrointestinal (GI) 4 (7.84%), Lymphomas 3 (5.88%) and 2 (3.92%) cases each of Bone Tumors and Central Nervous System (CNS) tumors. Breast related symptoms constituted the major presentation in young females (aged 18-35 years) in our Rural Cancer Hospital. This high percentage of Breast related symptoms points towards the increasing trend of Breast malignancies possibly overtaking cancer cervix in rural India, as already in the urban settlements of India as well as the increasing awareness in the females of rural India regarding early symptoms of carcinoma Breast.
High frequency of genotypic resistance in HIV‐1‐infected patients on highly active antiretroviral therapy with persistent low level viremia
Authors: Pellegrino D , Brígido L , Souza Cavalcanti J , Paula Ferreira J , Vidal J , Battaggia Gutierrez E 
Published: November 2012

BackgroundResistance is a major cause of virologic failure in HIV‐1‐infected patients; genotypic analyses optimize salvage therapy but technical constraints limit testing in plasma viral load (pVL) below 1000 copies/ml. Nevertheless a great amount of patients are failing therapy with a persistent low viral load, it is possible to obtain genotypic information at lower viremias although slight modifications are required during genotype standard procedures.ObjectiveTo assess genotypic resistance in HIV‐1‐infected patients with persistent low level viremia and virologic response after switching to genotype‐guided salvage therapy. To evaluate viral selection of mutation when previous genotypic information were available.Study designCohort prospective study in which eligible patients were at least 18 years old, provided informed consent, were on HAART for at least 12 months with two consecutive pVL between 200–999 copies/ml after achieving and maintaining viral suppression (two pVL <50 copies/ml). Modifications in genotype standard procedures included a larger volume of starting plasma, concentrating the sample by centrifugation and higher viral RNA input. Resistance was defined as the detection of any NRTI, NNRTI or PR major resistance mutations. Virologic response was assessed 12 weeks after salvage therapy.ResultsEighteen patients, 50% male, median age 52, median CD4 405 cells/mm3, median pVL 596 copies/ml, median of number of previous regimens 5, 17 (94%) with successful genotype. Resistance mutations were detected in 14 patients (77%). All patients had NRTI mutations, four patients had NNRTI mutations and ten patients had PR mutations, most common mutations were M41L, D67N, M184V, K103N, M46I, I47V, I54V and L90M. Of these fourteen patients, nine started a genotype‐guided salvage regimen and presented a pVL < 50 copies/ml after 12 weeks of follow up. For two patients there was previous genotypic information highlighting the selection and accumulation of resistance mutation during persistent low level viremia.ConclusionIn this group of heavily pretreated patients with persistent low viremia, a high frequency of genotypic resistance was observed; obtaining genotypic information may prevent further accumulation of resistance mutation and preserve future therapeutic options.