bluuebunny/crossref_metadata_2025_split huggingface dataset:
A - 49 Predictors of Post-Concussion Anxiety In Patients without Pre-Existing Anxiety History
Authors: Patel S , Zynda A J , Miller M , Burley C , French J , Ramirez N , Guercio H , Kegel N , Bunker N , Collins M , Kontos A P 
Published: July 2024

Abstract

Purpose
Identify factors contributing to anxiety in individuals without a pre-existing anxiety history post-concussion.

Method
Patients (n = 264, aged 9–68) presented to a specialty concussion clinic post-concussion. They completed a clinical interview, Immediate Post-Concussion Assessment and Cognitive Test (ImPACT), Post-Concussion Symptom Scale (PCSS), Concussion Clinical Profile Screening (CP-Screen), and Vestibular/Ocular-Motor Screening (VOMS). Anxiety group was determined by a positive anxiety/mood clinical profile on CP-Screen. Independent samples t-tests and chi-square tests examined differences in demographics, medical history, and injury characteristics between groups. Univariate logistic regressions (LR) informed a follow-up forward stepwise LR to identify best predictors of post-concussion anxiety group. Receiver operating characteristic (ROC) analysis of the area under the curve (AUC) was used to identify which predictors retained from the LR model best-discriminated anxiety status. Statistical significance was set a priori at p &lt; 0.05.

Results
Results of forward stepwise LR identifying factors contributing to post-concussion anxiety were significant (p &lt; 0.001) and accounted for 19% of the variance. The model accurately classified 82.2% of patients, with non-Sport Related Concussion (SRC) (OR = 2.94, 95%CI, 1.45–1.5.98, p = 0.003), history of ADHD/LD (OR = 2.85, 95%CI, 1.21–6.71, p = 0.02), positive vestibular profile (OR = 2.14, 95%CI, 1.06–4.33, p = 0.03), and days to first clinic visit (OR = 1.01, 95%CI, 1.01–1.015, p = 0.003) as significant predictors. ROC analysis of the AUC of this 4-factor model discriminated post-concussion anxiety from no anxiety (AUC, 0.77, 95%CI, 0.71–0.85, p &lt; 0.001).

Conclusions
Findings suggest that non-SRC, ADHD/LD history, positive vestibular profile, and delayed clinic visit, may contribute to post-concussion anxiety among patients without prior anxiety history. These predictors may guide clinicians in tailoring interventions to optimize recovery outcomes.
A - 53 Age of First Exposure to Football and Later-Life Health Issues in Community-Dwelling Adults
Authors: Rigney G , Dugan J , Bishay A , Jonzzon S , Jo J , Williams K , Zuckerman S , Terry D 
Published: July 2024

Abstract

Purpose
This study assessed whether age of first exposure (AFE) to football was associated with later-life psychiatric and neurobehavioral symptoms, cognitive difficulties, and general health problems in a cohort of former amateur football players.

Method
A cross-sectional survey study of men with a history of amateur football exposure was conducted using the ResearchMatch online platform. Independent variables included demographics, number of lifetime concussions, AFE to football (dichotomized as AFE &lt; 12 years vs. AFE ≥ 12 years), and total years of football participation. Main outcomes included current depressive (Patient Health Questionnaire-9), anxiety (Generalized Anxiety Disorders-7), cognitive (British Columbia Cognitive Complaints Inventory), and neurobehavioral symptoms (Neurobehavioral Symptom Inventory). T-tests (AFE &lt; 12 vs. AFE ≥ 12) and multivariable regressions assessed for associations between AFE and outcome variables, adjusting for age, number of prior concussions, and years of football exposure.

Results
A total of 107 male participants (mean age = 60.6 ± 15.1 years) reported an average of 4.2 ± 2.7 years of exposure to amateur football, with 41 participants reporting AFE &lt; 12 (38.3%). In multivariable analyses, AFE &lt; 12 was not a significant predictor of depressive (B = 0.51, SE = 1.25, p = 0.682), anxiety (B = 0.09, SE = 0.95, p = 0.926), cognitive (B = -0.65, SE = 0.77, p = 0.403), or neurobehavioral symptom scores (B = -0.56, SE = 2.93, p = 0.850). However, having more prior concussions were associated with worse depressive (B = 0.44, SE = 0.10, p &lt; 0.001), anxiety (B = 0.33, SE = 0.07, p &lt; 0.001), cognitive (B = 0.26, SE = 0.06, p &lt; 0.001), and neurobehavioral symptoms (B = 1.04, SE = 0.23, p &lt; 0.001).

Conclusions
AFE to football was not associated with adverse psychiatric, cognitive, or neurobehavioral difficulties. However, these outcomes were associated with a greater number of lifetime concussions.
A Bibliometric Analysis of the Top 100 Papers on Gluteal Augmentation
Authors: Daneshi Kian , Mansour Hamid Reza Khademi , Pacheco-Barrios Niels , Asaju Ayobami , Pérez Pachon Mauricio , Hoyos Alfredo , Khajuria Ankur 
Published: July 2024

Abstract

Background
Gluteoplasty or gluteal augmentation is a popular cosmetic procedure that is used to improve the volume, shape, and contour of the buttocks.

Objectives
This bibliometric analysis aims to characterize emerging research trends and to assess the methodological quality of the highest impact gluteoplasty research.

Methods
The 100 most-cited publications in gluteoplasty were identified on Web of Science, across all available journal years (from Inception to August 2023). Study details, including the citation count, main content focus, and outcome measures, were extracted and tabulated from each publication. Oxford Centre for Evidence Based Medicine level of evidence (LOE) of each study was assessed.

Results
The 100 most-cited publications regarding gluteoplasty were cited by a total of 2375 publications. Citations per publication ranged from 5 to 176 (mean 23.75 ± 25.86), with the highest-cited study being authored by Simonacci, discussing autologous fat grafting (n = 176). Most publications were LOE 5 (n = 55), representative of the large number of case series and reports. The number of publications for LOE 1, 2, 3, and 4 was 1, 9, 13, and 22, respectively. The main content focus was “surgical technique” in 38 publications, followed by “outcomes” (n = 34) and “risk factors/prognosis” (n = 10). Patient-reported outcome measures (PROMs) were used in 20 publications, and 33 publications reported aesthetic outcome measures.

Conclusions
This analysis demonstrates a need for improvement in research methodologies regarding gluteoplasty research. This advancement would be facilitated by robust, high-quality research through randomized control trials and multicenter studies, as well as the further development of validated PROMs for gluteoplasty.

Level of Evidence: 2
Survival outcomes after breast cancer surgery among older women with early invasive breast cancer in England: population-based cohort study
Authors: Miller Katie , Gannon Melissa Ruth , Medina Jibby , Clements Karen , Dodwell David , Horgan Kieran , Park Min Hae , Cromwell David Alan 
Published: July 2024

Abstract

Background
This study assessed the influence of age, co-morbidity and frailty on 5-year survival outcomes after breast conservation surgery (BCS) with radiotherapy (RT) versus mastectomy (with or without RT) in women with early invasive breast cancer.

Methods
Women aged over 50 years with early invasive breast cancer diagnosed in England (2014–2019) who had breast surgery were identified from Cancer Registry data. Survival estimates were calculated from a flexible parametric survival model. A competing risk approach was used for breast cancer–specific survival (BCSS). Standardized survival probabilities and cumulative incidence functions for breast cancer death were calculated for each treatment by age.

Results
Among 101 654 women, 72.2% received BCS + RT and 27.8% received mastectomy. Age, co-morbidity and frailty were associated with overall survival (OS), but only age and co-morbidity were associated with BCSS. Survival probabilities for OS were greater for BCS + RT (90.3%) versus mastectomy (87.0%), and the difference between treatments varied by age (50 years: 1.9% versus 80 years: 6.5%). Cumulative incidence functions for breast cancer death were higher after mastectomy (5.1%) versus BCS + RT (3.9%), but there was little change in the difference by age (50 years: 0.9% versus 80 years: 1.2%). The results highlight the change in baseline mortality risk by age for OS compared to the stable baseline for BCSS.

Conclusion
For OS, the difference in survival probabilities for BCS + RT and mastectomy increased slightly with age. The difference in cumulative incidence functions for breast cancer death by surgery type was small regardless of age. Evidence on real-world survival outcomes among older populations with breast cancer is informative for treatment decision-making.
Prosthetic home intervention induces cortical plasticity in paediatrics with congenital limb reduction
Authors: Borrell Jordan A , Karumattu Manattu Arun , Copeland Christopher , Fraser Kaitlin , D’Ovidio Andrew , Granatowicz Zach , Delgado Liliana , Zuniga Jorge M 
Published: July 2024

Abstract
Paediatrics with congenital upper-limb reduction deficiency often face difficulties with normal development such as motor skills, needing assistance with daily activities such as self-care limitations with certain movements, sports, or activities. The purpose of this non-randomized longitudinal controlled trial was to assess, using intent-to-treat analysis, the effects of an 8-week home intervention of prosthetic use on the sensorimotor cortex in paediatrics with congenital upper-limb reduction deficiency. A paediatric population with congenital upper-limb reduction deficiency (n = 14) who were aged 6–18 years and who had a 20° or greater range of motion in the appropriate joint of the affected arm to move the body-powered prosthesis were enrolled. An age- and sex-matched control group (n = 14) was also enrolled. Participants were non-randomized and fitted with a custom low-cost 3D printed prosthesis and participated in 8 weeks of prosthetic use training at home. Control participants utilized a prosthetic simulator. The home intervention incorporated daily use training and exercises utilizing the prosthesis in direct use and assistive tasks explained by the researchers. After the home intervention, both groups displayed significant improvements in gross manual dexterity. During prosthetic use with the affected limb, significant increases in oxygenated hemodynamic responses were only displayed in the left premotor cortex of the upper-limb reduction deficiency group. The novel findings of this non-randomized longitudinal controlled trial suggest that the intervention may have improved the functional role of the left hemisphere which translated to the improvement of learning direction during adaptation to visuomotor control. The prosthetic home intervention was assumed to provide closed-loop training which could provide a direct benefit to the motor development of paediatrics with upper-limb reduction deficiency.
Artificial intelligence-based fully automated stress left ventricular ejection fraction as a prognostic marker in patients undergoing stress cardiovascular magnetic resonance
Authors: Toupin Solenn , Pezel Théo , Hovasse Thomas , Sanguineti Francesca , Champagne Stéphane , Unterseeh Thierry , Duhamel Suzanne , Chitiboi Teodora , Jacob Athira J , Borgohain Indraneel , Sharma Puneet , Gonçalves Trecy , Martial Paul-Jun , Gall Emmanuel , Florence Jeremy , Unger Alexandre , Garot Philippe , Garot Jérôme 
Published: July 2024

Abstract

Aims
This study aimed to determine in patients undergoing stress cardiovascular magnetic resonance (CMR) whether fully automated stress artificial intelligence (AI)-based left ventricular ejection fraction (LVEFAI) can provide incremental prognostic value to predict death above traditional prognosticators.

Methods and results
Between 2016 and 2018, we conducted a longitudinal study that included all consecutive patients referred for vasodilator stress CMR. LVEFAI was assessed using AI algorithm combines multiple deep learning networks for LV segmentation. The primary outcome was all-cause death assessed using the French National Registry of Death. Cox regression was used to evaluate the association of stress LVEFAI with death after adjustment for traditional risk factors and CMR findings. In 9712 patients (66 ± 15 years, 67% men), there was an excellent correlation between stress LVEFAI and LVEF measured by expert (LVEFexpert) (r = 0.94, P &lt; 0.001). Stress LVEFAI was associated with death [median (interquartile range) follow-up 4.5 (3.7–5.2) years] before and after adjustment for risk factors [adjusted hazard ratio, 0.84 (95% confidence interval, 0.82–0.87) per 5% increment, P &lt; 0.001]. Stress LVEFAI had similar significant association with death occurrence compared with LVEFexpert. After adjustment, stress LVEFAI value showed the greatest improvement in model discrimination and reclassification over and above traditional risk factors and stress CMR findings (C-statistic improvement: 0.11; net reclassification improvement = 0.250; integrative discrimination index = 0.049, all P &lt; 0.001; likelihood-ratio test P &lt; 0.001), with an incremental prognostic value over LVEFAI determined at rest.

Conclusion
AI-based fully automated LVEF measured at stress is independently associated with the occurrence of death in patients undergoing stress CMR, with an additional prognostic value above traditional risk factors, inducible ischaemia and late gadolinium enhancement.
Leveraging the ETAS model to forecast mining microseismicity
Authors: Sedghizadeh Mohammadamin , van den Berghe Matthew , Shcherbakov Robert 
Published: July 2024

SUMMARY
Mining operations result in changes of the subsurface stress field that can lead to the occurrence of microseismic events. The development of strategies for forecasting and avoidance of significant events is crucial for safe and efficient operations of mines. One such example, discussed here is the observed induced microseismicity in soft rock potash mines. It is primarily driven by the rock excavations but can also be triggered by preceding events or can result from the delayed effects of plastic creep of soft rocks. Therefore, it is important from seismic hazard assessment and risk mitigation points of view to understand the statistical aspects of microseismicity in potash or other types of mines. In this study, the temporal evolution of the induced microseismicity from a potash mine in Saskatchewan is analysed and modelled. Specifically, the epidemic type aftershock sequence model is used to approximate the occurrence rate of the induced mining microseismicity. The estimated parameters signify that the microseismicity displays swarm-type characteristics with limited inter-event triggering. Moreover, the Bayesian predictive framework is used to compute the probabilities of the occurrences of the largest expected events above a certain magnitude for prescribed forecasting time intervals during the evolution of the sequence. This approach for computing the probabilities allows one to incorporate fully the uncertainties of the model parameters. The Markov Chain Monte Carlo sampling of the posterior distribution are used to generate parameter chains to quantify their variability. Furthermore, several statistical tests are conducted to assess the credibility of the obtained retrospective forecasts compared to the observed microseismicity. The obtained results show that the developed approach can accurately forecast the number of events and intensity of the sequence. It also provides a framework for computing the probabilities for the largest expected events.
The Soft Palate Enables Extreme Feeding and Explosive Breathing in the Fin Whale (Balaenoptera physalus)
Authors: Vogl A W , Petersen H , Gil K N , Cieri R L , Shadwick R E 
Published: July 2024

Synopsis
The evolution of lunge feeding in rorqual whales was associated with the evolution of several unique morphological features that include non-synovial ligamentous temporomandibular joints, a tongue that can invert and extend backward to the umbilicus, walls of the oral cavity that can dramatically expand, and muscles and nerves that are stretchy. Also, among the acquired features was an enlargement of the rostral end of the soft palate into an oral plug that occludes the opening between the oral cavity and pharynx and prevents water incursion into the pharynx during the engulfment phase of a feeding lunge. During this engulfment phase of a lunge, the volume of water entering the oral cavity can exceed the volume of the whale itself. Here, using dissection of fetuses and adults and a magnetic resonance imaging dataset of a fetus, we examine the detailed anatomy of the soft palate in fin whales. We describe several innovative features relative to other mammals, including changes in the attachment and positions of the major extrinsic muscles of the palate, alterations in the morphology of the pterygoid processes related to the palate and pharynx, and the presence of distinct muscle layers in the part of the palate caudal to the oral plug. Based on the anatomy, we present a model for how the soft palate is positioned at rest, and how it functions during feeding, breathing, and swallowing.
Barriers and facilitators to effective electronic health record-based sepsis screening in the pediatric intensive care unit
Authors: Sears Stacey M , Coughlin Anisha K , Nelson Kathryn , Stillwell Terri , Carlton Erin F , Flori Heidi R 
Published: July 2024

Abstract

Introduction
The Pediatric Surviving Sepsis Campaign supports the implementation of automated tools for early sepsis recognition. In 2019 the C.S. Mott Children’s Hospital Pediatric Intensive Care Unit deployed an electronic medical record (EMR)-based screening for early recognition and treatment of sepsis.

Materials and Methods
We analyzed all automated primary sepsis alerts, secondary screens, and bedside huddles from November 2019 to January 2020 (Cohort 1) and from November 2020 to January 2021 (Cohort 2) to identify barriers and facilitators for the use of this tool. We distributed surveys to frontline providers to gather feedback on end-user experience.

Results
In Cohort 1, 895 primary alerts were triggered, yielding 503 completed secondary screens and 40 bedside huddles. In Cohort 2, 925 primary alerts were triggered, yielding 532 completed secondary screens and 12 bedside huddles. Surveys assessing end-user experience identified the following facilitators: (1) 73% of nurses endorsed the bedside huddle as value added; (2) 74% of medical providers agreed the bedside huddle increased the likelihood of interventions. The greatest barriers to successful implementation included the (1) overall large number of primary alerts from the automated tool and (2) rate of false alerts, many due to routine respiratory therapy interventions.

Discussion
Our data suggests that the successful implementation of EMR-based sepsis screening tools requires countermeasures focusing on 3 key drivers for change: education, technology, and patient safety.

Conclusion
While both medical providers and bedside nurses found merit in our EMR-based sepsis early recognition system, continued refinement is necessary to avoid sepsis alert fatigue.
Pectoral major myocutaneous flap in our practice: about 25 cases
Authors: Opango Alban Déo Christian , Aziz Zakaria , Jaifi Abdelghafour , Ndelafei Divina , El Fatihi Meriem , Mansouri Hattab Nadia 
Published: July 2024

Abstract
The pectoralis major myocutaneous flap (PMMF) was described by Ariyan in 1979 for head and neck reconstructions. It is a safe flap, currently supplanted by free flaps in developed countries, but which remains very useful in developing countries. We report a series of 25 cases of PMMF reconstruction. All patients were treated for advanced stages of oral cavity cancer, where tumor excision left significant tissue loss. The reconstruction used PMMF, taken using the same technique. Supplanted by free flaps in developed countries, PMMF remains useful in developing countries. It is a flap that has numerous advantages (ease of collection, viability, low requirements in terms of instrumentation, etc.). Many variations have been described over the years.
Clinical outcomes of the Burnett “snake” maneuver shunt modification for ischemic priapism
Authors: Unal Selman , Karakus Serkan , Du Comb William , Burnett Arthur L 
Published: July 2024

Abstract

Background
Major ischemic priapism (IP) is defined as a persistent penile erection for &gt;4 hours. IP may cause serious complications, especially if prompt resolution is not achieved. Therefore, selecting the most effective and usable shunt technique is crucial in IP cases that are refractory to medical therapy.

Aim
To compare the effectiveness and complication risks of distal corporoglanular shunt procedures with and without the Burnett “snake” maneuver.

Methods
We conducted a retrospective study of patients who presented with IP and underwent surgical treatment at our institution between 2005 and 2021. The patients were categorized into 2 groups: group 1 (n = 26) underwent distal shunt + Burnett snake maneuver, and group 2 (n = 56) underwent distal shunt-only. Clinical history, parameters of IP, details of medical and surgical treatments, and follow-up information were evaluated.

Outcomes
Outcomes included differences in IP resolution and recurrence, functional erections, and complications between corporoglanular shunt procedures with and without the Burnett snake maneuver.

Results
In group 1, 24 of 26 patients (92.3%) experienced priapism resolution with a single surgical intervention, while this outcome was observed in 30 of 56 patients (53.6%) in group 2 (P &lt; .001). Notably, priapism recurrence was significantly lower in group 1, occurring in 1 of 24 patients (4.2%), as opposed to 8 of 30 patients (26.6%) in group 2 (P &lt; .001). Of the patients with documented sexual function status at follow-up, functional erections (capable of penetration with or without phosphodiesterase 5 inhibitors) were noted in 6 of 14 patients (42.8%) in group 1 and 13 of 26 patients (50%) in group 2 (P = .66).

Clinical Implications
This study provides valuable insights regarding technical aspects of distal shunt procedures with and without the Burnett snake maneuver for treating major IP episodes. These results can help surgeons with clinical decision making for patients who present with IP.

Strength and Limitations
Limitations include the single-site retrospective design with potential selection bias, inaccuracies in medical record data, challenges in controlling confounding variables, and the lack of validated questionnaire scores for erectile function evaluation.

Conclusion
Our study demonstrates that modifying distal shunt procedures using the Burnett snake maneuver significantly improves priapism resolution and effectively prevents further priapism episodes without introducing additional complications or erectile function loss, thereby distinguishing it from distal shunt–only procedures.