bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogen Evolution Atomic Cluster Catalysts-Decorated Hierarchical Nanoporous Zinc for on-Demand Hydrogen Generation By Metal Hydrolysis
Authors: Kubota Jo , Liu Jiaxin , Detsi Eric 
Published: August 2024

In recent years, there has been an increasing interest in nanoporous metals due to their wide range of applications, including catalysis, electrocatalysis, energy storage, actuation, and plasmonics. However, considerable attention has been given to precious nanoporous metals such as nanoporous Au, Pd, Pt, Ag, and Cu due to their low chemical reactivity, which makes them relatively easy to synthesize and characterize. Less precious nanoporous metals such as nanoporous Zn, Al, and Mg have been rarely fabricated and characterized because of their relatively high chemical reactivity 1. In this talk, I will present a novel, highly scalable approach to making hierarchical nanoporous zinc (NP-Zn) decorated with atomic clusters of hydrogen evolution catalysts for on-demand hydrogen generation by metal hydrolysis. Our approach involves selective etching in combination with galvanic replacement reactions. The conventional selective etching method requires several days to create a monolithic piece of NP-Zn 2. Our approach creates the same amount of hierarchical NP-Zn in less than 5 minutes, instead of several days. In our work, we used focused ion beam/scanning electron microscopy techniques to reveal the internal nanoscale morphology of the hierarchical NP-Zn, and small-angle X-ray scattering to analyze the pore size distribution. In general, when NP-Zn is used for hydrogen generation by metal hydrolysis, the hydrogen generation yield is low, typically around 20%. This is because zinc is naturally a poor hydrogen evolution material. Our process overcomes this issue by creating NP-Zn with its interface decorated with clusters of hydrogen evolution catalysts, which enables hydrogen generation yield exceeding 90% depending on the catalyst loading.

References

(1) Fu, J.; Welborn, S. S.; Detsi, E. Dealloyed Air- and Water-Sensitive Nanoporous Metals and Metalloids for Emerging Energy Applications. ACS Appl. Energy Mater.
2022, 5 (6), 6516–6544. https://doi.org/10.1021/acsaem.2c00405.
(2) Fu, J.; Deng, Z.; Lee, T.; Corsi, J. S.; Wang, Z.; Zhang, D.; Detsi, E. pH-Controlled Dealloying Route to Hierarchical Bulk Nanoporous Zn Derived from Metastable Alloy for Hydrogen Generation by Hydrolysis of Zn in Neutral Water. ACS Appl. Energy Mater.
2018, 1 (7), 3198–3205. https://doi.org/10.1021/acsaem.8b00419.
(Invited) Recent Progress in Functional Nanomaterials for Biosensing and Theranostics
Authors: Lin Yuehe 
Published: August 2024

In this talk, I will present an overview of our pioneering research in functional nanomaterials for biosensing and theranostics. Our work primarily focuses on novel materials such as protein cages, peptoids, single-atom nanozymes, and nanoflowers, and their applications in the field of biosensing and theranostics.
Building on my extensive background in developing materials and systems for biosensors, including immunosensors and microfluidic devices, we have explored the development of various smartphone-based biosensors. These biosensors are primarily based on DNA assays and immunoassays for point-of-care diagnostics, significantly enhancing the detection of disease biomarkers. Our research utilizes nanomaterials loaded with optical or electroactive signal molecules as amplification tags, dramatically improving the sensitivity in detecting disease biomarkers and food pathogens.
An exciting frontier in our research is the application of nano-peptoids in cell imaging, single-particle tracking, and cancer theranostics. The unique properties of nano-peptoids, including their biocompatibility and the ability for precise control over interactions, have opened new avenues in biomedicine and healthcare. These advancements hold promise for groundbreaking applications, particularly in enhancing the efficacy and precision of cancer diagnostics and treatment.
Moreover, the integration of 3D printing technology has enabled us to fabricate compact and efficient devices, a testament to our commitment to innovation in biosensor technology.
Throughout this talk, we will delve into the intricate details of these innovations, discussing their implications for the future of biosensing and theranostics.
Disposable Carbon Electrochemical Sensor Modified with Gold Nanoparticles for Creatinine Detection
Authors: Azzi Deborah , Silva Luiz , Neumann Amanda , Gatti Alexandre , Janegitz Bruno 
Published: August 2024

The social and economic impact of Chronic Kidney Disease on global health systems is devastating. It is estimated that annual spending on the treatment of Chronic Kidney Patients is in the order of 2 to 3% of annual health budgets. (1) In 2015, considering the United States, medical expenses for individuals with chronic kidney diseases were more than 64 billion dollars (1). Indeed, the early diagnosis of chronic kidney diseases is very important for the implementation of preventive measures that delay or even interrupt the progression to more advanced stages of the disease. In this context, this work aims to develop a disposable electrochemical sensor aimed at detecting creatinine for diagnosing kidney diseases. The flexible disposable lab made carbon sensor has been modified with gold nanoparticles. Morphological and electrochemical characterizations were carried out to better understand the proposed device. From cyclic voltammetry measurements, the proposed sensor showed reduction and oxidation peaks related to gold oxides formed on its surface. When adding creatinine there is a decrease in the electrochemical signal due to the adsorption of the target analyte. Therefore, it was inferred that it was possible to detect creatinine present in the solution from the reduction in the analytical response of the gold-modified electrode. Using the square wave voltammetry technique, in accordance with what was previously presented, when CNN was added to the solution, the Au-CNN interaction caused a reduction in the analytical response, therefore, with the increase in CNN concentration, this reduction increased linearly in the range of 0.5 to 10 µmol L-1 with a limit of detection and quantification, 0.15 and 0.45 µmol L-1, respectively, were calculated. Furthermore, it presented a sensitivity of 0.97 µA mol-1 L with a linear equation of Ipeak (µA) = 0.97 x C(CNN) + 0.23. Furthermore, the proposed sensor was successfully applied to determine creatinine in human serum samples and the recovery results were close to 100%. Therefore, the device modified with gold nanoparticles is an interesting alternative for creatinine detection.
References
(1) Luyckx V. A. et al. The global burden of kidney disease and the sustainable development goals, Bulletin of the World Health Organization Published online: 20 April 2018.
Paper-Based Electrochemical Sensors for Cancer Biomarkers Detection
Authors: Begay Makeiyla , Wilson Katelyn , Platero Justin , Platero Joshua , Plummer Dallen , Billey Wayant , Spencer Davina , Soundappan Thiagarajan 
Published: August 2024

Cancer is currently the third leading cause of death among the people of the Navajo Nation and is the most common cause of death worldwide. American Indians are often diagnosed when cancer has reached the advanced stages compared to other communities. Major contributors for the cancer inside the Navajo Nation is the exposure to uranium, other heavy metals, and radon gas. In the Navajo Nation, uranium mining boomed from 1944 to 1986; decades later, uranium tailings and toxic waste from the milling process have caused an increased rate of cancer in the Navajo Nation.
Further cancer detection and monitoring remain critical challenges in healthcare. This research explores the fabrication of paper-based electrochemical sensors modified with nanoparticles and antigens at the Nanoelectrochemical Analysis and Energy Storage Laboratory (NEST LAB) at Navajo Technical University (NTU) for the sensitive and selective detection of cancer biomarkers.
These electrochemical sensors harness the unique qualities of paper, such as low cost and ease of fabrication, combined with the specific binding capabilities of nanoparticles and antigens. Modifying paper electrode surfaces enhances sensitivity and selectivity, making these sensors a cost-effective and portable option for early cancer detection. In contrast to traditional methods like imaging and biopsies, electrochemical sensors are low-cost, offer minimally invasive screening, high sensitivity, and affordability, making them valuable tools in the early diagnosis and management of cancer. These sensors'accessibility and potential to detect cancer at its earliest stages can significantly improve patient outcomes, particularly in resource-limited areas such as Native American reservations.
Keywords: Cancer biomarkers, paper-based electrochemical sensors, nanoparticle modification, antigen modification, early detection, point-of-care diagnostics, cost-effective healthcare.
A Search for Suitable Water-Splitting Electrodes Using SEAL and Harpoon
Authors: Brodie Dustin K , Menningen Kenneth L , Riha Shannon C 
Published: August 2024

The search for suitable electrodes for photoelectrochemical water splitting extends across the periodic table. While III-V semiconductors exhibit superior light gathering properties, metal oxide semiconductors generally cost less and are more robust.
The Solar Energy Activity Laboratory (SEAL) 1 and the Heterogeneous Anodes Rapidly Perused for Oxygen Overpotential Neutralization (HARPOON)2 are simple experiments that can quickly scan for suitable oxide semiconductors. The SEAL experiment measures photocurrent and the HARPOON experiment measures oxygen production efficiency.
Electrodes made of oxides of Fe, Pd, In, Ni, Zn, Cd, Ga, and W were produced in our laboratory and evaluated using the SEAL and HARPOON experiments. The relative performance of these oxides and their mixtures were evaluated.
REFERENCES

J. R. McKone et al., “The Solar Army: A Case Study in Outreach Based on Solar Photoelectrochemistry, “ Rev. Adv. Sci. Eng.
3, 288 (2014).

S. E. Shaner et al., “Discovering Inexpensive, Effective Catalysts for Solar Energy Conversion: An Authentic Research Laboratory Experience,” J. Chem. Educ.
93, 650 (2016).
(Invited) Pilot Power Platform for Integrated Coupled Electrolysis of Furfural to Maleic Acid and Levulinic Acid to Valeric Acid
Authors: Zaffaroni Riccardo , Simões Catarina , Giling Erwin , Bubberman Saskia 
Published: August 2024

In recent years it has become evident that electrification of the chemical industry is essential to shift from a fossil based society to a renewable and sustainable one. In this talk, we will address development of a pilot scale setup to upconvert bioderived feedstocks to relevant building blocks for the chemical industry. Specifically, we focused our attention to the concept of paired electrolysis: oxidation of furfural to maleic acid coupled with reduction of levulinic acid to valeric acid within the same electrochemical cell. Within the framework of this mentioned reaction, we will show different steps of the reactions optimization, scale up, process intensification that eventually led to the construction and testing of pilot power platform installation with electrochemical surface area of 1m2 (10 cell stack 1000cm2) and
productivities of about 6kg/day (Figure 1). We will also focus on downstream process needed to go from crude electrolyte to pure maleic acid and pure valeric acid. Finally, we will present insights from technoeconomic analysis.
Biography:
PERFORM: Highly selective electrochemical conversions (performproject.eu)
Figure 1. Developed infrastructure for electrochemical conversion of bioderived feedstocks to maleic acid and valeric acid. Left: upstream electrochemical Power Platform. Right: electrodialysis pilot, first downstream process of maleic acid purification

Figure 1
Molten Salt Preparation of Carbon Nanostructures for Metal-Ion Storage Applications
Authors: Kamali Ali Reza 
Published: August 2024

Efficient electrical energy storage relies on the preparation of low-cost yet high-quality carbon nanostructures. This presentation introduces innovative molten salt approaches for generating such carbon materials, leveraging diverse carbon sources such as natural or synthetic graphite, biomass waste, and plastic materials. Electrochemical exfoliation of various graphite materials in molten salt is demonstrated to yield electrolytic carbon nanostructures, including graphene nanosheets, carbon nanotubes, and onion-like carbon nanoparticles. The distinctive morphology, structure, and electrical conductivity of these carbon materials are investigated, and their impact on Na-ion and Li-ion storage performances is thoroughly discussed. Furthermore, the presentation explores the molten salt-assisted carbonization of corn lignocellulosic waste, resulting in carbon materials with tailored morphological and compositional characteristics conducive to efficient Li-ion and Na-ion storage performance. Additionally, insights are provided into the transformation of waste plastic materials into graphene-based nanostructures through molten salt techniques, with a focus on their electrical and electrochemical performances. This comprehensive exploration not only underscores the versatility of molten salt methodologies in synthesizing diverse carbon nanostructures but also sheds light on their potential applications in advancing energy storage technologies.

References

A.R. Kamali*, H. Zhao, J. Alloy. Compd. 949 (2023) 169819
H. Zhao, A. Rezaei, A.R. Kamali*, J. Electrochem. Soc. 169 (2022) 054512
R. Li, A.R. Kamali*, Chem. Eng. Sci. 265 (2023) 118222
A.R. Kamali*, S. Li, Appl. Energy 334 (2023) 120692
A.R. Kamali*, J. Yang, Polym. Degrad. Stab. 177 (2020) 109184
A. Rezaei, B. Kamali, A.R. Kamali*, Measurement 150 (2020) 107087
A.R. Kamali* et al., J. Mater. Chem. A 5 (2017) 19126-19135
A.R. Kamali*, Carbon 123 (2017) 205-215
(Invited) Semiconducting Single-Walled Carbon Nanotubes: Stimulated Emission, Electron Spin, and Beyond
Authors: Ma Xuedan 
Published: August 2024

Great strides have been made in the understanding of electronic and optical properties of semiconducting single-walled carbon nanotubes (SWCNTs) in the past two decades. With optical transitions at near-infrared wavelengths, and diameter- and chirality-tunable electronic structures, SWCNTs are promising candidates for near-infrared nanolasers. In this talk, I will discuss our recent exploration of stimulated emission from SWCNTs by coupling them to whispering gallery modes supported by polymer microspheres through a self-assembly process.
In contrast to the many exciting developments in the excitonic frontier, electron spins, which are ubiquitous in solid state materials and highly relevant to spintronic and quantum information science, in SWCNTs are relatively less understood. In this talk, I will also discuss our recent study of electron spins in SWCNTs.
Characterization and Control of Carbon Nanotube Doping
Authors: Zeevi Gilad , Gilardi Carlo , Li Shengman , Passlack Matthias , Pitner Gregory , Mitra Subhasish , Li Shengman 
Published: August 2024

Carbon nanotube FETs show great promise for beyond-Si and monolithic 3D electronics, however there are still fundamental questions to explore. In particular, controlled N- and P- doping is a fundamental process module which can be used to engineer semiconductor resistance in un-gated regions such as the contact or extension, as well as optimize band-to-band tunneling leakage [1-4]. To-date both N- and P- doping has been demonstrated for CNT, but the optimal strategies for doping control and carrier density quantification have not been determined. In this work, we present a study of N- and P- doping using solid-state dopants and doping control strategy using a dielectric barrier of tunable thickness. A TCAD evaluation reveals the tradeoffs between carrier density and mobility for increasing dielectric barrier thickness, and reveals the critical role of dielectric constant in optimizing performance of spacer doping [5]. Multiple characterization approaches under evaluation help to correlate doping strength to experimentally measurable quantities with insight into the doping mechanisms. Finally, we will summarize potential approaches for improving doping control and quantification, and progress towards integration of the doping in highly-scaled high-performance carbon nanotube FETs [6].
[1] Z. Zhang, et al., “Complementary carbon nanotube metal-oxide-semiconductor field-effect transistors with localized solid-state extension doping,” Nature Electronics, 2023.
[2] Q. Lin, et al., “Band-to-band Tunneling Leakage Current Characterization and Projection in Carbon Nanotube Transistors,” ACS Nano, 2023.
[3] G. Zeevi, et al., “PN Junction and band to band tunneling in carbon nanotube transistors at room temperature,” Nanotechnology, 2021.
[4] L. Liyanage, et al., “VLSI-compatible carbon nanotube doping technique with low work-function metal oxides,” Nano Letters, 2014.
[5] C. Gilardi et al., “Barrier Booster for Remote Extension Doping and its DTCO for 1D & 2D FETs”, IEDM 2023
[6] S.Li, et al., “High-performance and low parasitic capacitance CNT MOSFET: 1.2 mA/μm at VDS of 0.75 V by self-aligned doping in sub-20 nm spacer,” IEDM 2023.
Establishment, Prediction, and Validation of a Nomogram for Cognitive Impairment in Elderly Patients With Diabetes
Authors: Wu Sensen , Pan Dikang , Wang Hui , Guo Julong , Zhang Fan , Ning Yachan , Gu Yongquan , Guo Lianrui 
Published: August 2024

Objective: The purpose of this study is to establish a predictive model of cognitive impairment in elderly people with diabetes.Methods: We analyzed a total of 878 elderly patients with diabetes who were part of the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014. The data were randomly divided into training and validation cohorts at a ratio of 6:4. The least absolute shrinkage and selection operator (LASSO) logistic regression analysis to identify independent risk factors and construct a prediction nomogram for cognitive impairment. The performance of the nomogram was assessed using receiver operating characteristic (ROC) curve and calibration curve. Decision curve analysis (DCA) was performed to evaluate the clinical utility of the nomogram.Results: LASSO logistic regression was used to screen eight variables, age, race, education, poverty income ratio (PIR), aspartate aminotransferase (AST), blood urea nitrogen (BUN), serum uric acid (SUA), and heart failure (HF). A nomogram model was built based on these predictors. The ROC analysis of our training set yielded an area under the curve (AUC) of 0.786, while the validation set showed an AUC of 0.777. The calibration curve demonstrated a good fit between the two groups. Furthermore, the DCA indicated that the model has a favorable net benefit when the risk threshold exceeds 0.2.Conclusion: The newly developed nomogram has proved to be an important tool for accurately predicting cognitive impairment in elderly patients with diabetes, providing important information for targeted prevention and intervention measures.
NUAK1-Mediated Phosphorylation of NADK Mitigates ROS Accumulation to Promote Osimertinib Resistance in Non–Small Cell Lung Carcinoma
Authors: Lin Wei , Wang Na , Wu Shihao , Diao Mingxin , Huang Quanfu , Li Kuo , Mei Peiyuan , Wang Xiaojun , Liao Yongde , Meng Yunchong 
Published: August 2024

Abstract
Osimertinib, a third generation epidermal growth factor receptor tyrosine kinase inhibitor, is approved as a first-line therapy in patients with advanced non–small cell lung carcinoma (NSCLC) with EGFR-activating mutations or the T790M resistance mutation. However, the efficacy of osimertinib is limited due to acquired resistance, highlighting the need to elucidate resistance mechanisms to facilitate the development of improved treatment strategies. Here, we screened for significantly upregulated genes encoding protein kinases in osimertinib-resistant NSCLC cells and identified NUAK1 as a pivotal regulator of osimertinib resistance. NUAK1 was highly expressed in osimertinib-resistant NSCLC and promoted the emergence of osimertinib resistance. Genetic or pharmacological blockade of NUAK1 restored the sensitivity of resistant NSCLC cells to osimertinib in vitro and in vivo. Mechanistically, NUAK1 directly interacted with and phosphorylated nicotinamide adenine dinucleotide kinase (NADK) at serine 64 (S64), which mitigated osimertinib-induced accumulation of reactive oxygen species (ROS) and contributed to the acquisition of osimertinib resistance in NSCLC. Furthermore, virtual drug screening identified T21195 as an inhibitor of NADK-S64 phosphorylation, and T21195 synergized with osimertinib to reverse acquired resistance by inducing ROS accumulation. Collectively, these findings highlight the role of the NUAK1-NADK axis in governing osimertinib resistance in NSCLC and indicate the potential of targeting this axis as a strategy for circumventing resistance.
Significance: Phosphorylation of NADK by NUAK1 diminishes ROS accumulation and confers resistance to osimertinib, identifying NUAK1-NADK signaling as a potential therapeutic target for improving the response to EGFR inhibition in lung cancer.
Associations between Dietary Patterns and Incident Colorectal Cancer in 114,443 Individuals from the UK Biobank: A Prospective Cohort Study
Authors: Skulsky Samuel L. , Koutoukidis Dimitrios A. , Carter Jennifer L. , Piernas Carmen , Jebb Susan A. , Gao Min , Astbury Nerys M. 
Published: August 2024

Abstract

Background:
Diet–disease association studies increasingly use dietary patterns (DP) to account for the complexity of the exposure. We assessed if a DP associated with type 2 diabetes mellitus, cardiovascular disease, and all-cause mortality is also associated with colorectal cancer.

Methods:
We used reduced rank regression on 24-hour recall data to identify DPs, explaining the maximum variation in four nutrient-response variables: energy density, saturated fatty acids, free sugars, and fiber density. Cox proportional hazards models examined prospective associations between DP adherence (coded in a continuous scale as z-scores as well as in quintiles) and incident colorectal cancer. Subgroup analyses were conducted for tumor site, age, and sex.

Results:
After exclusions, 1,089 colorectal cancer cases occurred in 114,443 participants over a median follow-up of 8.0 years. DP1 was characterized by increased intake of chocolate and confectionery; butter; low-fiber bread; red and processed meats; and alcohol, as well as low intake of fruits, vegetables, and high-fiber cereals. After accounting for confounders, including body mass, there were positive linear associations between DP1 and incident overall colorectal cancer (HR of quintile 5 vs. 1, 1.34; 95% confidence interval, 1.16–1.53, Ptrend = 0.005) and rectal cancer (HR of quintile 5 vs. 1, 1.58; 95% confidence interval, 1.27–1.96, Ptrend = 0.009) but not for proximal or distal colon cancers. No DP2–colorectal cancer association was observed.

Conclusions:
A DP previously associated with cardiometabolic disease is also associated with incident colorectal cancer, especially rectal cancers.

Impact:
These consistent associations of particular food groups with both cardiometabolic disease and this diet-related cancer strengthen the evidence base for holistic population dietary guidelines to prevent ill-health.