bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of the Menstrual Cycle on Energy Intake: A Systematic Review and Meta-analysis
Authors: Tucker Jessica A L , McCarthy Seth F , Bornath Derek P D , Khoja Jenna S , Hazell Tom J 
Published: July 2024

Abstract

Context
Energy intake may differ across the menstrual cycle, with some studies identifying greater energy intake in the luteal phase (LP) compared with the follicular phase (FP) and others finding no clear differences. To date, no study has systematically synthesized the available data to draw more definite conclusions while considering any methodological inconsistencies between studies.

Objective
The aim was to conduct a systematic review/meta-analysis in an effort to determine if there are differences in energy intake between the FP and LP.

Data Sources
A systematic search strategy was developed and the search was conducted in 5 databases for studies that investigated any changes in energy intake across menstrual phases.

Data Extraction
Using Covidence, studies were identified and included if they contained individuals between the ages of 18 and 45 years, maintained an average body mass index (BMI) of 18.5–25 kg/m2, had no history of disordered eating, and included energy intake and menstrual cycle measurements in the FP and LP.

Data Analysis
Effect sizes were calculated for each study and a random-effects model was used to pool the results of each study.

Results
Fifteen datasets were included consisting of 330 female participants with a mean age of 26 ± 4 years and mean BMI of 22.4 ± 2.3 kg/m2. Overall, there was a statistically significant difference (standardized mean difference = 0.69; P = .039) with increased energy intake in the LP compared with the FP (crude 168 kcal⋅d−1 average difference between phases).

Conclusion
Energy intake was found to be greater in the LP compared with the FP, providing insight into the effect of the menstrual cycle on energy intake. However, there were repeated methodological inconsistencies and future work should strive to utilize best practices for both energy intake measurement and menstrual phase specification.
Two listeners detect slightly more birds than a single listener when interpreting acoustic recordings
Authors: Iles David T , Francis Charles M , Smith Adam C , Weeber Russ , Friis Christian , Daly Lindsay 
Published: July 2024

Abstract
Acoustic recorders are increasingly important for monitoring bird populations and have potential to augment existing monitoring programs such as the North American Breeding Bird Survey (BBS). An advantage of acoustic recordings is that they can be reviewed multiple times by multiple experts, potentially yielding improved estimates of species abundance and community richness. Yet, few studies have examined how frequently successive listeners disagree on acoustic interpretations and how strongly estimates of species richness and abundance are altered when multiple experts review each recording. We assigned multiple expert listeners to interpret recordings at 690 BBS stops, and subsequently assigned second listeners to conduct a review of first listeners’ interpretations. We examined the extent to which listeners agreed with each other and quantified the effect of disagreements on resultant estimates of species occurrence, abundance, and stop-level richness. We also compared estimates from acoustic recordings to those obtained during simultaneous field surveys. Estimates were highly correlated for number of species per stop (r = 0.92) and detection probabilities of species (r = 0.97) based on first and second-listener data. Second listeners disagreed with ~9% of first listeners’ interpretations and added an average of ~15% additional species and 16% additional birds not reported by first listeners. Estimates based on acoustic recordings were also highly correlated with those obtained from field surveys, though listeners were unable to count flocks. A single expert reviewer can provide a reasonable approximation of the relative abundance and species composition of birds available for acoustic detection during BBSs. However, acoustic review by multiple listeners may still be important for species that are rare, difficult to identify, or of high conservation concern.
A new era of synthetic biology—microbial community design
Authors: Matuszyńska Anna , Ebenhöh Oliver , Zurbriggen Matias D , Ducat Daniel C , Axmann Ilka M 
Published: July 2024

Abstract
Synthetic biology conceptualizes biological complexity as a network of biological parts, devices, and systems with predetermined functionalities and has had a revolutionary impact on fundamental and applied research. With the unprecedented ability to synthesize and transfer any DNA and RNA across organisms, the scope of synthetic biology is expanding and being recreated in previously unimaginable ways. The field has matured to a level where highly complex networks, such as artificial communities of synthetic organisms, can be constructed. In parallel, computational biology became an integral part of biological studies, with computational models aiding the unravelling of the escalating complexity and emerging properties of biological phenomena. However, there is still a vast untapped potential for the complete integration of modelling into the synthetic design process, presenting exciting opportunities for scientific advancements. Here, we first highlight the most recent advances in computer-aided design of microbial communities. Next, we propose that such a design can benefit from an organism-free modular modelling approach that places its emphasis on modules of organismal function towards the design of multispecies communities. We argue for a shift in perspective from single organism–centred approaches to emphasizing the functional contributions of organisms within the community. By assembling synthetic biological systems using modular computational models with mathematical descriptions of parts and circuits, we can tailor organisms to fulfil specific functional roles within the community. This approach aligns with synthetic biology strategies and presents exciting possibilities for the design of artificial communities.
Graphical Abstract
A Molecular Method to Assess Viability of Phytophthora in Infected Wood Following Phytosanitary Heat Treatment
Authors: Leal Isabel , Feau Nicolas , Uzunovic Adnan , Foord Brett , Hamelin Richard C. 
Published: July 2024

International trade in wood products is an important component of the global economy. However, wood and wood products may have pests associated with them that could be introduced into importing countries, posing phytosanitary risks and leading to the implementation of regulatory restrictions that affect wood trade. The application of heat to kill wood-associated pests has been a successful phytosanitary method to reduce their spread. To evaluate the efficacy of wood heat treatment to kill fungal and fungus-like pathogens, the method of choice has been to grow organisms in cultures for subsequent identification. However, some plant pathogens can be difficult or impossible to grow in axenic cultures, and a molecular method can still be useful for assessing pathogen viability after heat treatment. RNA is a single-stranded molecule that is responsible for the transcription of genes. Since it becomes rapidly unstable after cell death, it provides a measure of viability. We therefore designed and tested RNA-based molecular diagnostic assays targeting essential genes and assessed their presence after heat treatment in wood colonized by four Phytophthora species of phytosanitary concern ( P. × multiformis, P. cinnamomi, P. lateralis, and P. ramorum) through reverse transcription and real-time polymerase chain reaction (RT-qPCR). Our assays differentiate between genomic and mRNA as the TaqMan probes span exon–intron junctions. We validated these RT-qPCR assays to assess heat treatment efficacy of Phytophthora-inoculated wood. These assays can be very useful tools to assess the effectiveness of current and emerging phytosanitary wood treatments. [Formula: see text] Copyright © 2024 His Majesty the King in Right of Canada, as represented by the Minister of Natural Resources Canada. This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Innovative Learning Activities to Prepare Nursing Students for the Next Generation NCLEX
Authors: Gibbons Wanda R. , Stevenson Shannon M. , Mutic Abby D. 
Published: July 2024

Abstract
The purpose of this course innovation was to introduce Next Generation NCLEX (NGN)-style questions and create supplemental cooperative learning assignments (CLAs) to enhance content mastery in a prelicensure maternity course. The course itself is divided into three modules focusing on maternal, newborn, and women’s health. Three CLAs and two Canvas quizzes were developed to reinforce the course content and integrate NGN-style case studies and questions. The CLAs and quizzes aligned with the course module content. Anecdotally, students endorsed the CLAs as a positive experience, emphasizing the value of learning to set care priorities for maternity patients.
A Study of Factors Contributing to Emotional Exhaustion in Online Nursing Students
Authors: Snellgrove Susan , Gatling Lori 
Published: July 2024

Abstract
Emotional exhaustion in online nursing students leads to attrition in educational and professional settings. Few studies have been performed on practicing nurses enrolled in online programs. The purpose of this study was to explore factors contributing to emotional exhaustion in nursing students. Survey methodology targeted licensed practical nurses, registered nurses, and advanced practice registered nurses enrolled in online programs. Data collected from 116 students included demographics and answers to closed- and open-ended questions regarding emotional exhaustion. Participants reported high levels of emotional exhaustion related to multiple factors. Findings from this study will be used to identify at-risk students and interventions to decrease attrition and increase student success.
Improving Mental Health Literacy in Nursing Students: Integrating Mental Health Throughout the Curriculum
Authors: Gamez Vicki , Gunning Thomas 
Published: July 2024

Abstract
As more patients seek help for acute mental health conditions in all sectors of health care, the demand for nurses trained to care for this population is outpacing the supply. Nursing schools have not been successful in educating students with the knowledge, skills, and attitudes needed to provide care. The purpose of this study was to integrate mental health concepts throughout the entire curriculum in a two-year associate degree nursing program and examine its effects on developing mental health literacy in prelicensure students.
Trigger Warnings in Nursing Education: Psychiatric Mental Health Instructors’ Practices and Perspectives
Authors: Neathery Melissa 
Published: July 2024

Abstract
Psychiatric mental health (PMH) nursing education covers topics that some students find potentially distressing and anxiety-producing. Trigger warnings are commonly found in entertainment and social media venues, but there is little research to explore the use of trigger/content warnings in undergraduate nursing education. This current research surveyed PMH nursing instructors (n = 48) and found that most give trigger warnings and believe them to be helpful. However, there is no consistency on how and when warnings are provided, nor their content. Overall, results indicate that trigger warnings may be one aspect of implementing supportive and trauma-informed pedagogy.
SGLT-2 inhibitors: new horizons for rheumatologists
Authors: Chakrabarti Katherine , McCune W. Joseph 
Published: July 2024

Purpose of review
Sodium glucose cotransporter 2 (SGLT2) inhibitors are a class of medications initially developed for the treatment of diabetes, although their cardiac and renal protective benefits are far reaching. There has been marked interest in the rheumatology community to adopt these medications into our clinical practice, particularly for chronic kidney disease with persistent proteinuria.

Recent findings
SGLT2 inhibitors have been approved for patients with type 2 diabetes mellitus, heart failure with reduced or preserved ejection fraction, atherosclerotic cardiovascular disease in the setting of type 2 diabetes mellitus, as well as chronic kidney disease with proteinuria. Large studies on SGLT2 inhibitors have largely excluded patients with proteinuric chronic kidney disease due to autoimmune glomerulonephritis due to concerns for confounding from immunosuppression. The Dapagliflozin and Prevention of Adverse Outcomes in CKD Trial (DAPA-CKD) showed that SGLT2 inhibition decreased progression of renal disease in patients with IgA nephropathy. Expanding this to other autoimmune glomerulonephropathies, several small studies have shown improvements in proteinuria in patients with lupus nephritis treated with SGLT2 inhibitors. A study evaluating safety of SGLT2 inhibitors in patients with lupus identified no specific concerns even with concomitant use of immunosuppression.

Summary
Small studies have shown that SGLT2 inhibitors can been utilized safely and efficaciously in patients with lupus nephritis. Additional research is needed to identify where these medications fit into the rheumatology treatment armamentarium.
Antimelanoma differentiation antigen 5-positive dermatomyositis: an update
Authors: Lu Xin , Peng Qinglin , Wang Guochun 
Published: July 2024

Purpose of review
Antimelanoma differentiation antigen 5-dermatomyositis (MDA5-DM) is a complex and serious systemic autoimmune disease that primarily affects the skin and lungs. In this review, we aimed to provide new insights into the clinical features, pathogenesis, and practical management approach for this disease.

Recent findings
Although lung lesions are prominent in most patients with MDA5-DM, they are now recognized as heterogeneous diseases. Peripheral blood lymphocyte count can serve as a simple and reliable laboratory parameter for categorizing MDA5-DM into three subgroups: mild, medium, and severe. Recent studies have implicated viral infection, genetic factors, autoimmunity against MDA5, multiple immune cells, and interferons as significant contributors to MDA5-DM pathogenesis. In addition to traditional treatments with glucocorticoids and immunosuppressants, many new approaches, including new biologics and targeted agents, have been explored. Additionally, infection is a common complication of MDA5-DM, and prophylaxis or treatment of the infection is as important as treating the primary disease.

Summary
Knowledge of clinical characteristics and pathogenesis of MDA5-DM has grown in recent years. Although many new therapeutic approaches have been explored, further studies are required to confirm their efficacy.
Knee Arthrodesis Surgical Technique
Authors: Couso Megan , Sherman Nathan , Lowe Jason 
Published: July 2024

Summary:
Knee arthrodesis is a procedure seldomly performed. One surgical approach involves employing a nonmodular intramedullary nail in conjunction with a total knee arthroplasty cutting guide to prepare the bone for knee arthrodesis.

Video available at:

https://ota.org/education/ota-online-resources/video-library-procedures-techniques/knee-arthrodesis-surgical
Assessment of Gross Motor Skills in Ponseti-treated Children With Idiopathic Clubfoot at 3 Years Old: Insights from the Peabody Developmental Motor Scale 2
Authors: Rice Samuel W. , Moisan Alice , Rhodes Leslie , Locke Lindsey L. , Nolan Vikki G. , Wells Aristea , Kelly Derek M. 
Published: July 2024

Background:
Congenital talipes equinovarus, or clubfoot, can lead to lifelong functional impairments, including diminished gross motor skills (GMS), if left untreated. The Ponseti method corrects idiopathic clubfoot through casting and bracing. Given the importance of GMS in childhood development, this technique must be optimized to support childhood and long-term health outcomes. This study examined immediate posttreatment GMS in 3-year-old children treated with Ponseti, hypothesizing that they would perform on par with their nonclubfoot peers.

Methods:
Data from 45 children (33 to 46 mo of age) treated for idiopathic clubfoot were analyzed. The Peabody Developmental Motor Scales, 2nd edition, was used to assess GMS, and logistic regression identified factors influencing Gross Motor Quotient (GMQ) scores.

Results:
Approximately half (n=22) of the patients exhibited below-average GMS (11th to 25th percentile), with 11 scoring below the 10th percentile. Initial deformity severity, gender, and cast numbers did not impact GMQ. Repeat percutaneous tenotomy was associated with lower GMQs. Brace compliance significantly reduced odds of low GMQs by up to 80%. Age at testing and additional surgery were also linked to below-average and poor GMQs.

Conclusions:
GMS appeared to be impaired in almost half of the 3-year-old patients treated for idiopathic clubfoot, so our hypothesis was disproven. Repeat percutaneous tenotomy was associated with lower GMS, necessitating future recognition of patients who might be at risk of relapse. Brace noncompliance emerged as a significant risk factor, emphasizing early identification of these patients and education for their parents. This study offers a benchmark for clinicians and parents, but research on long-term outcomes is needed.

Level of Evidence:
Level II, prospective cohort study.
Society of Critical Care Medicine and American Society of Health-System Pharmacists Guideline for the Prevention of Stress-Related Gastrointestinal Bleeding in Critically Ill Adults
Authors: MacLaren Robert , Dionne Joanna C. , Granholm Anders , Alhazzani Waleed , Szumita Paul M. , Olsen Keith , Barletta Jeffrey F. , Møller Morten Hylander , Karvellas Constantine J. , Wischmeyer Paul , DePriest Ashley , Carlos Victor , Argetsinger Debora , Carothers John J. , Lee Rosemary , Napolitano Lena , Perri Dan , Naylor Douglas F. 
Published: July 2024

RATIONALE:
Critically ill adults can develop stress-related mucosal damage from gastrointestinal hypoperfusion and reperfusion injury, predisposing them to clinically important stress-related upper gastrointestinal bleeding (UGIB).

OBJECTIVES:
The objective of this guideline was to develop evidence-based recommendations for the prevention of UGIB in adults in the ICU.

DESIGN:
A multiprofessional panel of 18 international experts from dietetics, critical care medicine, nursing, and pharmacy, and two methodologists developed evidence-based recommendations in alignment with the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology. Conflict-of-interest policies were strictly followed during all phases of guideline development including task force selection and voting.

METHODS:
The panel members identified and formulated 13 Population, Intervention, Comparison, and Outcome questions. We conducted a systematic review for each question to identify the best available evidence, statistically analyzed the evidence, and then assessed the certainty of the evidence using the GRADE approach. We used the evidence-to-decision framework to formulate the recommendations. Good practice statements were included to provide additional guidance.

RESULTS:
The panel generated nine conditional recommendations and made four good practice statements. Factors that likely increase the risk for clinically important stress-related UGIB in critically ill adults include coagulopathy, shock, and chronic liver disease. There is no firm evidence for mechanical ventilation alone being a risk factor. Enteral nutrition probably reduces UGIB risk. All critically ill adults with factors that likely increase the risk for stress-related UGIB should receive either proton pump inhibitors or histamine-2 receptor antagonists, at low dosage regimens, to prevent UGIB. Prophylaxis should be discontinued when critical illness is no longer evident or the risk factor(s) is no longer present despite ongoing critical illness. Discontinuation of stress ulcer prophylaxis before transfer out of the ICU is necessary to prevent inappropriate prescribing.

CONCLUSIONS:
The guideline panel achieved consensus regarding the recommendations for the prevention of stress-related UGIB. These recommendations are intended for consideration along with the patient’s existing clinical status.
Implementation of sentinel node biopsy in high-risk endometrial cancer
Authors: Occhiali Tommaso , Vizzielli Giuseppe , Mariani Andrea 
Published: July 2024

Purpose of review
Endometrial cancer is the most common gynecologic malignancy and sentinel lymphnode biopsy is accepted as a valid alternative to lymphadenectomy for staging purposes. Recently, sentinel node biopsy has been also extended to high-risk disease where risk of nodal involvement is higher.

Recent findings
Our review focuses on the definition of high-risk disease and how there are different concepts of high-risk in the scientific community. While the sensitivity of sentinel node biopsy has been established and accepted in lower risk endometrial cancers, only in recent years retrospective and prospective evidence has been published. Ultrastaging allows to identify more nodal disease that would normally be overlooked by traditional staging, allowing proper adjuvant therapy to be administered. The longstanding question of whether lymphadenectomy in high-risk settings is a therapeutic or a staging procedure remains open. Retrospective data, however, show that oncologic outcomes are not compromised by sentinel node biopsy.

Summary
Sentinel node biopsy is a valid alternative to traditional, more extensive nodal staging: with the addition of ultrastaging, it has more sensitivity than lymphadenectomy with less surgical morbidity. Ongoing trials will definitively establish if oncological outcomes are affected by sentinel node biopsy, but retrospective data are encouraging.
How to treat advanced Hodgkin lymphoma?
Authors: Rossi Cédric , Casasnovas René-Olivier 
Published: July 2024

Purpose of review
In this review, we analyzed the different therapy options in patients with advanced Hodgkin lymphoma (HL).

Recent findings
The treatment of advanced HL has greatly evolved during the last decade even still based on polychemotherapy. Mature data established that the better strategies require Positron emission tomography (PET)-driven treatments which allow to optimize the balance between disease control and both immediate and late treatment adverse effects, leading to cure most patients while minimizing the risk of toxicity. Indeed, PET-driven deescalated strategies offer the better treatment option. The recent incorporation of targeted therapies, anti-CD30 or anti-programmed cell death protein 1 (PD1) in combination with chemotherapy should quickly change the game and be a step forward to still decrease the risk of treatment toxicity and improve the cure rate.

Summary
The standard of care for advanced HL remains currently PET-driven chemotherapy and should rapidly evolve with the addition of targeted therapy combined with chemotherapy.