bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the potential impact of sodium–glucose cotransporter‐2 inhibitor “canagliflozin” on the hepatic damage triggered by hypertension in rats
Authors: Hassan Fatma E. , El‐Mosallamy Aliaa E. M. K. , Khalifa Mohamed Mansour , Aljuaydi Samira H. , Ali Merhan E. , Hosny Sara Adel , Bastawy Nermeen 
Published: July 2024

AbstractHypertension (HTN) is a prevalent chronic disease. HTN and liver disease association is extensively noted. Thus, finding a medication that can alleviate HTN and its accompanying liver insult would be promising. This study investigated the potential impacts of canagliflozin “sodium–glucose cotransporter‐2 inhibitor” on the liver of the Nω‐nitro‐L‐arginine methyl ester (L‐NAME)‐induced HTN rat model. Twenty‐four adult male rats were divided into four groups; negative control group, canagliflozin group, L‐NAME group: 50 mg/kg of L‐NAME was injected daily for 5 weeks and L‐NAME + canagliflozin group: 1 week after L‐NAME injection both L‐NAME + canagliflozin (40 mg/kg) were given concomitantly daily for further 4 weeks. Liver functions, serum lipid profile, hepatic oxidative/nitrative stress biomarkers, gene expression of lipogenic enzymes, B‐cell lymphoma 2 (Bcl2), and DNA fragmentation, were measured. Besides, hepatic histology and immunohistochemistry of nuclear factor kappa B (NF‐κB) and endothelial nitric oxide synthase (eNOS) were assessed. Canagliflozin improved hepatic lipogenesis via the downregulation of fatty acid synthase (FAS) and transcriptional regulatory element binding protein 1c (SREBP1c) genes leading to an improved serum lipid profile. Further, canagliflozin modified the eNOS/inducible nitric oxide synthase (iNOS) pathway and decreased the NF‐κB immunoreactivity besides restoring the oxidants–antioxidants balance; increased reduced glutathione concomitant with declined malondialdehyde. This improvement of the liver was mirrored by the significant restoration of liver architecture and confirmed by the preserved liver DNA content and upregulation of the antiapoptotic Bcl2 mRNA level and attenuation of the alanine transaminase, aspartate aminotransferase. In conclusion, canagliflozin is a promising anti‐hypertensive and hepatic‐supportive medication.Research Highlights
Canagliflozin's antioxidant, anti‐inflammatory, anti‐lipogenic, and antiapoptotic characteristics mitigate remote liver compromise caused by hypertension.
Canagliflozin can be exploited as a hepatoprotective and antihypertensive medication.
Factors that influence the angular error in active knee angle reproduction tests: A systematic review and meta‐analysis
Authors: Wieber Juliane , Müller‐Rahmel Leon , Reer Rüdiger , Rein Robert , Braunstein Bjoern 
Published: July 2024

AbstractPurposeThe systematic review and meta‐analysis investigated subject‐independent test factors that influence the absolute angle error in active knee angle reproduction tests.MethodsFive electronic databases were searched to identify relevant studies published before 20 December 2023. Studies were included that were published in either English or German and that investigated joint proprioception in the healthy knee. Included studies were also required to have participants 18–60 years old and free of lower‐limb injury, neurological disorders and diseases affecting joint position sense. Risk of bias was assessed using a Cochrane risk‐of‐bias tool.ResultsOf the 2023 articles identified, 26 studies (1082 participants) were included in the meta‐analysis. The meta‐analysis showed a significant pooled standard mean difference in the absolute angular error for body orientation, direction of movement and fatigue. Active knee angle reproduction tests were found to have a lower absolute angular error when performed in the sitting position compared to the prone position (SMD = −0.56; 95% CI = −1.00 to −0.12). The absolute angular error was found to be greater in cases of knee flexion compared to knee extension (SMD = 0.71; 95% CI = 0.18–1.24). General and local muscle fatigue were found to result in a higher absolute angular error (SMD = 1.39; 95% CI = 1.04–1.75).ConclusionHence, fatigue, body orientation and direction of movement influence the extent of the absolute angular error in active knee angle reproduction tests. Practitioners should be aware that the test conditions and the patient's level of fatigue can affect the results of such tests and that directly comparing results obtained using different test protocols may not be appropriate. The test protocol should be well documented and applied consistently in the clinical setting.Level of EvidenceLevel III, systematic review with meta‐analysis.
Superior load‐to‐failure in an all‐suture anchor system for all‐inside meniscal repair compared to a PEEK‐cage anchor system in an experimental cadaveric test setting
Authors: Pichler Lorenz , Kiss Gyula , Sator Thomas , Schuller Andrea , Kandathil Sam A. , Hofbauer Marcus , Koch Thomas , Hirtler Lena , Tiefenboeck Thomas 
Published: July 2024

AbstractPurposeThe purpose of this study was to compare the biomechanical properties of a latest generation all‐suture anchor repair device (ASARD) for meniscal repair with that of a latest generation PEEK‐cage anchor repair device (PCARD) in an experimental setting using cadaveric menisci.MethodsTwenty‐six menisci were obtained from the knees of fresh body donors. Artificially created meniscal lesions were treated randomly, using a single stitch with either an ASARD or a PCARD. Cyclic biomechanical testing, utilising a universal material testing machine and following an established protocol, was carried out and load‐to‐failure (LTF), displacement, stiffness, and mode‐of‐failure (MOF) reported.ResultsMean LTF was found to be 61% higher in the ASARD group at 107.10 N (standard deviation [SD], 42.34), compared to 65.86 N (SD, 27.42) in the PCARD group with statistical significance (p = 0.022). The ASARD exhibited a trend towards higher stiffness (10.35 N; SD, 3.92 versus 7.78 N; SD; 3.59) and higher displacement at cycles one, 100, and 499 (1.64, 3.27, and 4.17 mm versus 0.93, 2.19, and 2.83 mm) compared to the PCARD. Cheese wiring was the most common mode‐of‐failure in both groups (76.9%).ConclusionsThis study demonstrates that an ASARD shows a higher mean LTF than a PCARD when compared in an experimental biomechanical setting.Level of evidenceLevel III
Diagnosing popliteofibular ligament injuries in anterior cruciate ligament‐injured knees: A prospective magnetic resonance imaging study investigating the inter‐ and intraobserver reliability of identification of the popliteofibular ligament
Authors: Heylen Steven , Braeckevelt Thomas , Verdonk Peter , Krause Matthias , Michielsen Jozef 
Published: July 2024

AbstractPurposeThe aim of our study was to investigate the intra‐ and interobserver reliability for the identification of the popliteofibular ligament (PFL) in magnetic resonance imaging (MRI) scans in patients with an anterior cruciate ligament (ACL) injury and ascertain the prevalence of PFL tears in ACL‐injured knees without clinically high‐grade posterolateral corner injury.MethodsMRI readings were performed retrospectively by two surgeons on 84 patients who underwent ACL reconstruction in our department. The presence of the PFL on both sagittal and coronal images as well as the presence of PFL tears was noted. Readings were repeated 6 weeks later for one observer. The κ value was calculated to determine the intra‐ and interobserver reliability for identification of the PFL and the prevalence of PFL tears was ascertained.ResultsThe PFL was visualized in 90.5%−91.7% of MRI scans. The intra‐ and interobserver reliability of visualizing the PFL on MRI had an κ value of 0.63 and 0.66 (substantially reliable), respectively. The intraobserver reliability for identification of PFL tears had an κ value of 0.26 (fair reliability). We found a 4.8% prevalence of PFL tears in ACL‐injured knees.ConclusionsThere is substantially reliable intra‐ and interobserver reliability for the identification of the PFL on MRI scans but only fair reliability for the identification of PFL tears. A 4.8% prevalence of PFL tears in ACL‐injured knees without clinically confirmed high‐grade posterolateral corner injury can be observed in our series.Level of EvidenceLevel IV.
Risk factors for recurrent biliary obstruction following suprapapillary placement of a plastic stent as preoperative biliary drainage for perihilar biliary malignancy
Authors: Kataoka Kunio , Ishikawa Takuya , Yamao Kentaro , Mizutani Yasuyuki , Iida Tadashi , Uetsuki Kota , Onoe Shunsuke , Mizuno Takashi , Ebata Tomoki , Kawashima Hiroki 
Published: July 2024

AbstractBackground/PurposeThe usefulness of endoscopic biliary stenting by deploying a plastic stent suprapapillary, called inside‐stent (IS) placement, as preoperative biliary drainage (PBD) for perihilar biliary malignancy (PHBM) has been demonstrated. This study investigated risk factors for recurrent biliary obstruction (RBO) after IS placement.MethodsConsecutive patients with potentially resectable PHBM treated with IS placement as PBD between 2017 and 2023 at Nagoya University Hospital were retrospectively reviewed.ResultsA total of 157 patients were included, with RBO occurring in 34 (22%) patients. The non‐RBO rates were 83% at 30 days, 77% at 60 days, and 57% at 90 days. The most common cause of RBO was stent occlusion (n = 14), followed by segmental cholangitis (n = 12) and stent migration (n = 8). Stent migration and occlusion occurred more frequently within and after 1 week post‐stenting, respectively. In multivariate analysis, biliary infection before IS was the sole risk factor for RBO, with a hazard ratio of 2.404 (95% confidence interval 1.163–4.972; p = .018). This risk was reduced by temporary endoscopic nasobiliary drainage prior to definitive IS placement.ConclusionsBiliary infection before IS was identified as an independent risk factor for RBO in patients with PHBM with IS as PBD.Clinical Trial RegisterClinical trial registration number: UMIN000025631.
Hydrological and vegetation changes in North Africa over the past 23 000 years: a comparative study of watershed areas of the Nile River using remote sensing and compound‐specific δ2H and δ13C from the Eastern Mediterranean Sea
Authors: Sinoussy KHALED S. , Naraoka Hiroshi , Seki Osamu , Hassaan MAHMOUD A. , Okazaki Yusuke 
Published: July 2024

ABSTRACTHydroclimate variation and vegetation changes of the Nile River watershed area in northeast Africa since the Last Glacial Maximum (LGM) were reconstructed based on n‐alkanes, their carbon isotope ratios (δ13Cn‐alkanes), and their hydrogen isotope ratios (δ2Hn‐alkanes) in sediments from ODP Site 967 in the Eastern Mediterranean Sea. The results were compared with the present vegetation cover in the watershed areas using ArcGIS. The average proportion of current grassland in the Equatorial Lake and Ethiopian Highland Plateaus watershed areas was 45.8 and 64.7%, respectively. δ2Hn‐alkanes ranged from −199 to −127‰ and co‐varied with insolation change response to orbital forcing. Depleted δ2Hn‐alkanes were found from deglaciation to the middle Holocene, suggesting increased precipitation during the African Humid Period (AHP) from 15 to 5 ka caused by northward migration of the Intertropical Convergence Zone. However, lower precipitation was inferred by enriched δ2Hn‐alkanes during the LGM and late Holocene. δ13Cn‐alkanes at Site 967 did not show a trend in harmony with δ2Hn‐alkanes and instead exhibited millennial‐scale variations ranging from –25.9 to –33.2‰. These δ13Cn‐alkanes values consistently indicated a C4 grass‐dominated environment in the watershed areas of the River Nile since the LGM, persisting through the AHP and into the present. Reconstructions demonstrated orbital and abrupt forcing of hydroclimate variability while maintaining generally grass‐dominated vegetation with weak precipitation feedback over the late Quaternary.
Considerations for conducting systematic reviews: A follow‐up study to evaluate the performance of various automated methods for reference de‐duplication
Authors: McKeown Sandra , Mir Zuhaib M. 
Published: July 2024

AbstractSearching multiple resources to locate eligible studies for research syntheses can result in hundreds to thousands of duplicate references that should be removed before the screening process for efficiency. Research investigating the performance of automated methods for deduplicating references via reference managers and systematic review software programs can become quickly outdated as new versions and programs become available. This follow‐up study examined the performance of default de‐duplication algorithms in EndNote 20, EndNote online classic, ProQuest RefWorks, Deduklick, and Systematic Review Accelerator's new Deduplicator tool. On most accounts, systematic review software programs outperformed reference managers when deduplicating references. While cost and the need for institutional access may restrict researchers from being able to utilize some automated methods for deduplicating references, Systematic Review Accelerator's Deduplicator tool is free to use and demonstrated the highest accuracy and sensitivity, while also offering user‐mediation of detected duplicates to improve specificity. Researchers conducting syntheses should take automated de‐duplication performance, and methods for improving and optimizing their use, into consideration to help prevent the unintentional removal of eligible studies and potential introduction of bias to syntheses. Researchers should also be transparent about their de‐duplication process to help readers critically appraise their synthesis methods, and to comply with the PRISMA‐S extension for reporting literature searches in systematic reviews.
High‐resolution melting analysis to authenticate deer‐derived materials in processed products in China using a cytochrome oxidase I mini‐barcode
Authors: Feng Jian , Ren Qiqi , Xie Anzhen , Jiang Zixiao , Liu Yangyang 
Published: July 2024

AbstractBACKGROUNDDeer‐derived materials (antler, venison, fetus, penis, bone, tail, and others) are some of the most valuable traditional animal‐based medicinal and food materials in China. In production, processing, and trade, the quality of deer products varies. The market is confusing, and counterfeit and shoddy products are common. There is an urgent need to establish an accurate identification method.RESULTSTwo pairs of primers suitable for identifying deer‐derived medicinal materials were obtained by screening the cytochrome oxidase I (COI) sequences of 18 species from nine genera of the deer family. The two primers were used to identify the species and adulteration of 22 batches of commercially available deer‐derived products with a mini‐barcode combining high‐resolution melting (HRM) technology and methodical investigation. Deer‐derived materials (sika and red deer) were correctly identified by species using varying DNA amounts (1 to 500 ng). The two pairs of primers COI‐1FR and COI‐2FR yielded melting temperatures (Tm) of 80.55 to 81.00 °C and 82.00 to 82.50 °C for sika deer, and 81.00 to 82.00 °C and 81.40 to 82.00 °C for red deer. Twenty‐two batches of commercially available samples were analyzed by HRM analysis and conventional amplification sequencing, and it was found that the species samples had an error rate of species labeling of 31.8%. Four batches of samples were identified as mixed (adulterated) in the HRM analysis.CONCLUSIONThe combination of DNA mini‐barcode with HRM analysis facilitated the accurate identification of species of deer‐derived materials, especially the identification of samples in an adulterated mixed state. © 2024 Society of Chemical Industry.
Subjective grade of apprehension during the pivot‐shift test reflects patient‐reported outcomes more than conventional pivot‐shift test grade after ACL reconstruction
Authors: Nakamae Atsuo , Tsukisaka Kazuhiro , Deie Masataka , Miyamoto Ayato , Eguchi Akio , Kato Tomohiro , Nekomoto Akinori , Adachi Nobuo 
Published: July 2024

AbstractPurposeTo investigate whether the pivot‐shift test reflects patient‐reported outcomes 1 year after anterior cruciate ligament (ACL) reconstruction based on a multicentre prospective cohort study.MethodsThis study included patients who underwent primary ACL reconstruction using the hamstring tendons. The pivot‐shift test grades were determined according to the International Knee Documentation Committee (IKDC) form as 0, 1+, 2+ or 3+. In addition, patients' subjective apprehension during the pivot‐shift test were classified as 0 (no‐apprehension), 1+ (mild‐apprehension), 2+ (moderate‐apprehension) or 3+ (severe‐apprehension). In this study, a positive pivot‐shift test was defined as grade 1+ or higher.ResultsA total of 837 patients were enroled in this study. One year postoperatively, there was no significant difference in the Knee injury and Osteoarthritis Outcome Score (KOOS), IKDC score, Lysholm knee scale and Tegner activity scale between the positive (118 patients) and negative (719 patients) groups of the conventional IKDC grading of the pivot‐shift test. However, when divided into two groups based on the apprehension grading of the pivot‐shift test after surgery, the postoperative scores were significantly lower in the apprehension‐positive group (114 patients) than those in the apprehension‐negative group (723 patients) on the Tegner activity scale and KOOS Symptom, Sports/Rec and Quality of Life subscales.ConclusionsPatients' subjective apprehension during the pivot‐shift test after ACL reconstruction was significantly associated with the postoperative Tegner activity scale and three subscales of the KOOS. However, there was no association between the conventional IKDC grading of the pivot‐shift test and any patient‐reported outcomes postoperatively.Level of EvidenceLevel II.
Ultracompact 3D Splitter for Single‐Core to Multi‐Core Optical Fiber Connections Fabricated Through Direct Laser Writing in Polymer
Authors: Baghdasaryan Tigran , Vanmol Koen , Thienpont Hugo , Berghmans Francis , Van Erps Jürgen 
Published: July 2024

AbstractThe deployment and advancement of high‐bandwidth communication networks, quantum information systems, and sensing platforms relying on multi‐core optical fibers (MCFs) are challenged by the scarcity of cost‐effective, compact, and efficient optical interfacing components. This study introduces an unprecedented 3D‐printed 1 × 4 splitter for MCFs fabricated with 2‐photon polymerization‐based direct laser writing. The pivotal element is a triangular cross‐section 3D multimode interference (MMI) coupler, supplemented with S‐bends and adiabatic tapers to facilitate the splitting of a signal from a single core of a single‐mode fiber into four cores of a multi‐core fiber. All components are initially designed and assessed to minimize loss and polarization dependence across the C‐ and L‐bands using optical simulation. Subsequently, a proof‐of‐concept model of the splitter, compactly integrated within the fiber volume, featuring a remarkably short length of 180 µm and insertion loss of ≈−3 dB, is fabricated. The manufacturing speed, minimal loss, component compactness, and flexibility of the approach, collectively present promising avenues for pioneering developments in MCF‐coupling components.
Complications of Chemical Peels, Lasers, and Energy‐Based Device Procedures Performed by Core Cosmetic Physicians: A Retrospective Analysis
Authors: Murray Taryn N. , Lohray Rishabh , Schultz Kelly P. , Boutros Sean , Friedman Paul M. 
Published: July 2024

ABSTRACTBackgroundThere has been a proliferation of physicians of different levels of experience and training offering nonsurgical cosmetic procedures. Rising demand, compounded by increasing utilization of new and existing technologies by numerous physician specialties, compels discussion of adequate standardized training and patient safety.MethodsA retrospective chart review of patients who presented to our single site dermatology clinic for managment of complications following chemical peel, laser or energy‐based device treatments performed by core cosmetic physicians between the years of 2013 and 2024 was conducted. Core cosmetic physicians included plastic surgery, facial surgery/otolaryngology, oculoplastic surgery, and dermatology. Charts were reviewed for documentation of the type of complication, procedure causing the complication, and physician credentials, and referral source.ResultsTwenty‐five patients were identified as having complications from chemical peeling, laser treatment or energy‐based devices. Devices implicated included CO2 laser (fractional or fully ablative), chemical peels, 1064 nm long‐pulsed Nd:YAG laser, 1320 nm Nd:YAG laser, intense pulsed light, 595 nm pulsed dye laser, Q‐switched Nd:YAG laser, radiofrequency with and without microneedling, and 1550 nm erbium‐doped fiber laser. Complications included hypertrophic scarring, atrophic scarring, post‐inflammatory erythema, post‐inflammatory hyperpigmentation, and post‐inflammatory hypopigmentation.ConclusionsEven in experienced hands, complications can arise. It is imperative that all physicians offering cosmetic treatments are equipped to recognize clinical endpoints, identify and manage complications, or make a timely referral to decrease the risk of a permanent and potentially devastating esthetic outcome for patients.
Boosting the Cell Harvesting Performance of Poly(di(ethylene glycol)methyl ether methacrylate) Cell Release Layers via Copolymerization of Photo‐ and Thermoresponsive Monomers
Authors: Jiang Siyu , Yang Sijia , Lei Wenwei , Liu Zhiwei , Schönherr Holger 
Published: July 2024

AbstractThe performance of the cell‐selective thermoresponsive poly(di(ethylene glycol)methyl ether methacrylate) (PDEGMA) cell harvest system is shown to be drastically enhanced by exploiting the combination of photoresponsive spiropyran derivates and PDEGMA in copolymerized brushes. The analysis of copolymerized 1′‐(2‐methacryloxyethyl)‐3′,3′‐dimethyl‐6‐nitrospiro(2H‐1‐benzopyran‐2,2′‐indoline) (SPMA) (DEMGA) di(ethylene glycol)methyl ether methacrylate brushes revealed that a minor adjustment of the SPMA/DEGMA ratios results in a significant alternation of wettability as well as protein adsorption, when switching the temperature from 37 to 22 °C and alternately irradiating using different light wavelengths (from 530 to 365 nm). Thin P(SPMA‐co‐DEGMA) layers supported pancreatic tumor PaTu 8988t cells with high cell viability. Copolymer layers with 2.5% SPMA/DEGMA led to the highest efficiency of enzyme‐free cell release with very good cell viability. The release is induced by cooling the cell culture medium to 22 °C and irradiating the surface with 365 nm light. Compared to neat PDEGMA, the P(SPMA‐co‐DEGMA) layers showed a threefold increase in the speed of the change of cell morphology of the attached cells and a >5 times increased fraction of detached cells, which underlines the potential of these dual responsive PDEGMA systems for optimized performance in the facile capture, culture, and release of different cell lines.