bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploiting the anti-fibrotic effects of statins on thoracic aortic aneurysm progression: results from a meta-analysis and experimental data
Authors: Myasoedova Veronika A. , Rega Sara , Valerio Vincenza , Moschetta Donato , Massaiu Ilaria , Bonalumi Giorgia , Esposito Giampiero , Rusconi Valentina , Bertolini Francesca , Perrucci Gianluca Lorenzo , Poggio Paolo 
Published: August 2024

AimsThoracic aortic aneurysm (TAA) that progress to acute aortic dissection is often fatal and there is no pharmacological treatment that can reduce TAA progression. We aim to evaluate statins’ effects on TAA growth rate and outcomes using a meta-analysis approach.Methods and resultsA detailed search related to the effects of statins on TAA was conducted according to PRISMA guidelines. The analyses of statins’ effects on TAA growth rate were performed on 4 studies (n = 1850), while the impact on outcomes was evaluated on 3 studies (n = 2,867). Patients under statin treatment showed a reduced TAA growth rate (difference in means = −0.36 cm/year; 95%CI: −0.64, −0.08; p = 0.013) when compared to controls, patients not taking statins. Regarding the outcomes (death, dissection, or rupture of the aorta, and the need for operative repair), statins exhibited a protective effect reducing the number of events (log odds ratio = −0.56; 95%CI: −1.06, −0.05; p = 0.030). In vitro, the anti-fibrotic effect of atorvastatin was tested on vascular smooth muscle cells (VMSC) isolated from patients with TAA. Our results highlighted that, in transforming growth factor beta 1 (TGF-β1) pro-fibrotic condition, VSMC expressed a significant lower amount of collagen type I alpha 1 chain (COL1A1) when treated with atorvastatin (untreated = +2.66 ± 0.23 fold-change vs. treated = +1.63 ± 0.09 fold-change; p = 0.014).ConclusionStatins show a protective effect on TAA growth rate and adverse outcomes in patients with TAA, possibly via their anti-fibrotic properties on VSMC. Given the current lack of effective drug treatments for TAA, we believe our findings highlight the need for more in-depth research to explore the potential benefits of statins in this context.
Research trends and hotspot evolution of exercise-regulated myokines: a bibliometric analysis from 2003 to 2023
Authors: Sun Zhiyuan , Wu Zekai , Zhu Lei , Li Xinhe , Xu Dongdong , Tian Xuewen , Mao Dewei 
Published: August 2024

BackgroundThe lack of physical activity is a common issue in modern society and is considered a major risk factor for various chronic non-communicable diseases. Bioactive factors secreted by skeletal muscle during exercise play a crucial role in inter-organ interactions. Since the concept of “myokines” was proposed in 2004, hundreds of regulatory myokines have been identified. Visual analysis of research on exercise-regulated myokines is significant to explore research hotspots and frontiers in this field.MethodsResearch literature on exercise-regulated myokines from 2003 to 2023 in the “Web of Science” database was used as the data source. Knowledge maps were drawn using “VOS Viewer, CiteSpace, and R-bibliometrix” software.ResultsA total of 1,405 papers were included, showing a fluctuating yet slow growth in annual publications. The United States and China led in the number of publications and collaboration networks. Harvard University ranked first with 120 publications. CIBER (centrality 0.16) and the University of California System (centrality 0.16) were pivotal in advancing this field. PEDERSEN BK led author rankings with 41 publications and 1,952 citations. FRONTIERS IN PHYSIOLOGY ranked first among journals with 64 publications and the highest g-index (39), while PLoS One had the highest h-index (25) and most citations (2,599). Key co-cited reference clusters included #1 skeletal muscle dysfunction, #2 obesity, #6 ASCs, and #7 adaptive immunocytes. Pontus Boström’s paper had a notable citation burst intensity of 77.37. High-frequency keywords were “exercise” (509), “skeletal muscle” (452), and “expression” (293), with long-term keywords such as #0 irisin, #2 insulin resistance, #3 transcription, and #6 physical activity. Recently, keywords like “physical exercise,” “resistance exercise,” “aerobic exercise,” “insulin,” and “oxidative stress” have emerged.ConclusionResearch in the field of exercise-regulated myokines shows an overall upward trend. The focus areas include myokines mediated by different types of exercise, the interaction of irisin-mediated muscle with other organs, and the important role of myokine-mediated oxidative stress in exercise simulation.
Interlinking FinTech and eHealth: a qualitative study
Authors: Al-Anezi Fahad 
Published: August 2024

IntroductionThis study investigates the integration of financial technology (FinTech) and electronic health (eHealth) to explore the opportunities, challenges, and implications arising from their interlinkage in Saudi Arabia.MethodsUtilizing qualitative semi-structured interviews with 26 participants—including physicians, patients, technical and administrative managers, and FinTech consultants—the research adopts an inductive approach to understand diverse perspectives.ResultsKey findings reveal significant benefits such as improved efficiency in administrative processes, enhanced access to healthcare services, increased financial inclusion, better decision-making, improved patient experience, and the promotion of innovation and sustainability. However, barriers including regulatory challenges, data privacy and security concerns, interoperability issues, the digital divide, resistance to change, and cost implications were also identified.ConclusionOverall, the integration of FinTech and eHealth holds substantial promise for advancing healthcare delivery in Saudi Arabia. Future implications include the expansion of telehealth services, an increase in startups, the integration of wearable health devices, blockchain-based systems, evolving regulatory frameworks, and heightened collaborations. Addressing the identified challenges is crucial for realizing the full potential of this integration.
Associations of heavy metal exposure with diabetic retinopathy in the U.S. diabetic population: a cross-sectional study
Authors: Meng Chunren , Gu Chufeng , Cai Chunyang , He Shuai , Lai Dongwei , Qiu Qinghua 
Published: August 2024

BackgroundMounting evidence suggests a correlation between heavy metals exposure and diabetes. Diabetic retinopathy (DR) is a prevalent and irreversible complication of diabetes that can result in blindness. However, studies focusing on the effects of exposure to heavy metals on DR remain scarce. Thus, this study aimed to investigate the potential correlation between heavy metals exposure and DR.MethodsA total of 1,146 diabetics from the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018 were included in this study. Heavy metal levels were measured via urine testing. Weighted logistic regression, Bayesian kernel machine regression (BKMR), weighted quantile sum (WQS) regression, and restricted cubic spline (RCS) were utilized to investigate the potential relationships between exposure to 10 heavy metals and DR. Finally, subgroup analysis was conducted based on the glycemic control status.ResultsAmong the 1,146 participants, 239 (20.86%) were diagnosed with DR. Those with DR had worse glycemic control and a higher prevalence of chronic kidney disease compared to those without DR. Moreover, both the WQS regression and BKMR models demonstrated a positive relationship between exposure to mixed heavy metals and the risk of DR. The results of weighted logistic regression revealed a positive correlation between cobalt (Co) and antimony (Sb) exposure and the risk of DR (OR = 1.489, 95%CI: 1.064–2.082, p = 0.021; OR = 1.475, 95% CI: 1.084–2.008, p = 0.014), while mercury (Hg) exposure was found to promote DR exclusively in the group with good glycemic control (OR = 1.509, 95% CI: 1.157–1.967, p = 0.003). These findings were corroborated by the results of the RCS analysis.ConclusionHeavy metal exposure is associated with an increased risk of DR, especially Sb, Co, and Hg exposure. Nevertheless, well-designed prospective studies are warranted to validate these findings.
Effects of different Chinese traditional exercises on mental health during the COVID-19 pandemic: a systematic review and meta-analysis
Authors: Zhang Shiqing , Liu Min , Zhao Lijin 
Published: August 2024

IntroductionAs the COVID-19 outbreak escalated into a global pandemic, there was a significant surge in mental health issues worldwide. Over the past three decades, traditional Chinese exercises (TCEs) has gained increasing recognition for its ability to regulate mental well-being. The aim of this study (PROSPERO CRD42024516002) was to comprehensively assess and carry out a meta-analysis on the impact of traditional Chinese exercise on personal mental well-being amidst the COVID-19 pandemic.MethodsLiterature with publication dates from 2020 to 2023 was searched in four databases, including CNKI, Wanfang, Pubmed and Web of science. The literature was selected layer by layer according to the PRIMA guidelines, and then the quality of the included literature was assessed using the Cochrane Risk assessment tool.ResultsA total of 174 articles were screened, and 10 studies met the criteria and were included in the study. The results showed that TCEs had a positive effect on anxiety symptoms [SMD = −1.68, I2 = 98.40, 95%CI = (−2.80, −0.56), p = 0.00] and depressive symptoms [SMD = -1.23, I2 = 89.23, 95%CI = (−1.87, −0.58), p = 0.00]. The data of subgroup analysis showed that Baduanjin exercise had the best effect on reducing anxiety [SMD = −2.29, I2 = 98.3, 95%CI = (−3.69, −0.89), p &lt; 0.000]. Individuals who practiced TCEs less than or equal to 30 min each time had the best effect on anxiety [SMD = −2.06, I2 = 96.2%, p &lt; 0.000] and depression [SMD = −1.90, I2 = 68.4, 95%CI = (−2.25, −1.55), p = 0.042]. Individuals who trained TCEs more than 7 times a week were most likely to reduce symptoms of anxiety [SMD = −4.30, I2 = 92.6, 95%CI = (−6.78, −1.81), p &lt; 0.000] and depression [SMD = −2.39, I2 = 0.0, 95%CI = (−2.91, −1.87), p = 0.625]. It is worth noting that TCEs had the most significant effect on the improvement of depression in people aged 30–50 years [SMD = −1.58, I2 = 89.0, 95%CI = (−3.05, −0.10), p = 0.003].ConclusionDuring the global pandemic, traditional Chinese sports have shown a positive and significant impact on reducing symptoms of anxiety and depression, and have played a significant role in improving mental health problems.Systematic review registration: PROSPERO, identifier CRD42024516002, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024516002.
An exploratory qualitative interview study on grassroots esports in sports clubs
Authors: Baumann André C. K. , Pallesen Ståle , Mentzoni Rune A. , Kolberg Eirin , Waagbø Vegard , Sørensen Anders , Kristensen Joakim H. 
Published: August 2024

AimThe current study aimed to explore grassroots esports in sports clubs in Norway from the perspective of volunteer esports leaders.Method and resultsFifteen volunteers were recruited from grassroots esports initiatives in various sports clubs and were interviewed via online video conferencing using a pre-developed semi-structured interview guide. Data was analyzed using inductive thematic analysis with a realist approach, which generated the following themes: (1) Local community impact at the center of motivation, (2) lack of support threatens the operations of the initiatives, and (3) competency development to overcome barriers. The participants perceived the grassroots esports initiatives as essential for children in the local community and as the core of their motivation as volunteers. Several challenges were mentioned for sustaining the initiatives, such as maintaining motivation, resource management, and recruiting new volunteers. Finally, competency and qualified esports trainers were mentioned as necessary for a high-quality offer.ConclusionThe grassroots esports initiatives in sports clubs are viewed by volunteer esports leaders to affect the local community positively. However, there are challenges tied to the operation of such initiatives, such as engaging volunteers and raising competence. Future research should investigate barriers to help develop strategies to support grassroots esports initiatives.
Chlorantraniliprole Enhances Cellular Immunity in Larvae of Spodoptera frugiperda (Smith) (Lepidoptera: Noctuidae)
Authors: Liu Qingyan , Deng Xiaoyue , Wang Liuhong , Xie Wenqi , Zhang Huilai , Li Qing , Yang Qunfang , Jiang Chunxian 
Published: August 2024

The innate immunity of insects encompasses cellular and humoral defense mechanisms and constitutes the primary defense against invading microbial pathogens. Cellular immunity (phagocytosis, nodulation, and encapsulation) is primarily mediated by hemocytes. Plasmatocytes and granulocytes play an important role and require changes in the cytoskeletons of hemocytes. However, research investigating the immunological impacts of insecticides on the fall armyworm (FAW), Spodoptera frugiperda, remains scarce. Therefore, we conducted a study to investigate the effects of chlorantraniliprole exposure on cellular immunity in FAW larvae. Our findings revealed the presence of five types of hemocytes in the larvae: prohemocytes, plasmatocytes, granulocytes, oenocytoids, and spherulocytes. The LD10, LD20, and LD30 of chlorantraniliprole affected both the morphology and total count of some hemocytes in the larvae. Moreover, larvae exposed to chlorantraniliprole showed increased phagocytosis, nodulation, and encapsulation. To determine the mechanism of the enhanced cellular immunity, we studied plasmatocytes in the spread state and the cytoskeleton in hemocytes. It was found that the spreading ratio of plasmatocytes and the areas of the cytoskeletons in hemocytes were increased after chlorantraniliprole treatment. These results suggest that exposure to chlorantraniliprole results in an enhanced immune response function in FAW larvae, which may be mediated by cytoskeletal changes and plasmatocyte spreading. Consequently, this study provides valuable insights into the cellular immune response of FAW larvae to insecticide exposure.
Systemic Analyses of Anti-Cell-Senescence Active Compounds in Camellia Sect. Chrysantha Chang and Their Mechanisms
Authors: Wu Jiacheng , Bai Quanzi , Chen Jianghua , Yang Zhenbiao , Zhu Xiaoyue 
Published: August 2024

Aging is an irreversible pathophysiological process for all organisms. The accumulation of senescent cells in pathological sites or tissues is recognized as the major cause of diseases and disorders during the aging process. Small molecules that reduce senescent cell burdens have gained increasing attention as promising intervention therapeutics against aging, but effective anti-senescence agents remain rare. Camellia Sect. Chrysantha Chang is documented as a traditional Chinese herbal medicine used by ethnic groups for many medical and health benefits, but its effect on aging is unclear. Here, we investigated the anti-senescence potential of eight C. Sect. Chrysantha Chang species. The results show that ethyl acetate fractions from these C. Sect. Chrysantha Chang species were able to delay the senescence of H9c2 cardiomyocytes except for C. pingguoensis (CPg). N-butanol fractions of C. multipetala (CM), C. petelotii var. grandiflora (CPt), and C. longzhouensis (CL) showed a senescent cell clearance effect by altering the expression levels of senescent-associated marker genes in the DNA-damage response (DDR) pathway and the senescent cell anti-apoptotic pathway (SCAPs). By using UPLC-QTOF-MS-based non-targeted metabolomics analyses, 27 metabolites from Sect. Chrysantha species were putatively identified. Among them, high levels of sanchakasaponin C and D in CM, CPt, and CL were recognized as the key bioactive compounds responsible for senescent cell clearance. This study is the first to disclose and compare the anti-cell-senescence effect of a group of C. Sect. Chrysantha Chang, including some rare species. The combination of senescent markers and metabolomics analyses helped us to reveal the differences in chemical constituents that target senescent cells. Significantly, contrary to the C. chrysantha var. longistyla (CCL), which is widely cultivated and commercialized for tea drinks, CM, CPt, and CL contain unique chemicals for managing aging and aging-related diseases. The results from this study provide a foundation for species selection in developing small-molecule-based drugs to alleviate diseases and age-related dysfunctions and may potentially be useful for advancing geroscience research.
Análise do perfil dos visitantes do Parque Estadual Morro do Diabo em Teodoro Sampaio (SP)
Authors: Alves Glenda Lislie Maciel , Ferreira Maria Eugênia Moreira Costa 
Published: August 2024

O objetivo da pesquisa é identificar o perfil dos visitantes do Parque Estadual Morro do Diabo em Teodoro Sampaio, São Paulo para compreender as características da demanda a fim de contribuir com a gestão do parque na melhoria da qualidade da oferta turística. Para alcançar esse objetivo foi aplicado um questionário a uma amostra de 264 visitantes que visitaram a Trilha do Morro do Diabo. Entre os principais resultados encontrados estão: dos visitantes do parque são 60,6% estudantes e 37,5% trabalhadores, entre eles professores; 79,5% passará somente o dia no parque, o que os configuram como excursionistas; os motivos que os levaram a visitar o parque, estão o contato com a natureza (42,1%), aprendizado sobre o parque (21,0%) e a busca por aventura (18,3%); o nível de satisfação da visita é alto, 66,1% se encontram muito satisfeitos e 32,1% satisfeitos com a experiência vivenciada. Conclui-se que pelo tipo de público levantado, maior parte relacionada à educação, o parque poderia investir mais em atividades educativas e de interpretação ambiental.
Association between Proton Pump Inhibitors, Immune Checkpoint Inhibitors, and Acute Kidney Injury: A Nested Case–Control Study
Authors: Yamawaki Chinami , Nakagawa Shunsaku , Ikuta Keiko , Katsube Yurie , Imayoshi Natsuki , Shigetsura Yuki , Hira Daiki , Yamamoto Shinya , Matsubara Takeshi , Yanagita Motoko , Terada Tomohiro 
Published: August 2024

Key Points

This is the first study to use a large database of patients with cancer to examine the association between the studied drugs and AKI.The use of either proton pump inhibitors or immune checkpoint inhibitors was associated with an increased risk of AKI.However, their additive interaction was not identified.

Background
An association between proton pump inhibitor (PPI) use and an increased risk of AKI has been confirmed. This study aimed to evaluate the effects of PPI use on the risk of AKI in patients with cancer who were administered immune checkpoint inhibitors (ICIs), a class of drugs used in cancer treatment, and in those who were not.

Methods
We used a database provided by the Health, Clinic, and Education Information Evaluation Institute, which included demographic data, diagnoses, prescriptions, and laboratory results. We conducted a nested case–control study of 38,930 patients with cancer who were new PPI or ICI users and had no history of AKI before cohort entry. The odds ratio (OR) for AKI was estimated using conditional logistic regression models.

Results
During a mean follow-up of 8.3 months, 5870 cases of AKI were identified (incidence rate, 21.9/100 person-years). Compared with never or past PPI use without ICI use, the adjusted ORs of AKI for current PPI use without ICI use, past or never PPI use with prior ICI use, current PPI use with prior ICI use were 2.20 (95% confidence interval [CI], 2.01 to 2.40), 1.72 (95% CI, 1.37 to 2.17), or 2.62 (95% CI, 1.75 to 3.93), respectively. The risk of AKI in patients treated with both PPIs and ICIs was not higher than the additional or multiplication of the risks in those who were treated with PPIs or ICIs alone.

Conclusions
This study reinforces the association between PPI and ICI use and the increased risk of AKI. Although the interaction between the two drug classes was not detected, these findings highlight the need for careful monitoring and evaluation of kidney function in patients treated with PPIs and ICIs.
Особенности использования программного обеспечения бухгалтерского учета в условиях цифровизации
Authors: Джалалов К.З. 
Published: August 2024

В статье раскрываются вопросы автоматизации бухгалтерского учета в современных условиях. Рассмотрены преимущества и недостатки применения бухгалтерских информационных систем и их разновидности.
The article reveals the issues of accounting automation in modern conditions. The advantages and disadvantages of using accounting information systems and their varieties are considered.
ЖАЗДЫК БУУДАЙДЫН НЕГИЗГИ ООРУЛАРДЫ ЖУГУЗУУЧУЛУГУНА УРУКТАРДЫ СЕБҮҮНҮН АЛДЫНДА ДАРЫЛОО ЫКМАЛАРЫНЫН ТААСИРИ
Authors: Адылбаев Н.Б. , Самиева Ж.Т. 
Published: August 2024

Исследование влияния методов предпосевной обработки семян на пораженность яровой пшеницы основными болезнями является важным аспектом сельскохозяйственной практики. Учитывая значительные потери урожая, вызванные болезнями, изучение эффективности различных методов обработки семян имеет большое значение для повышения устойчивости пшеницы к заболеваниям и обеспечения высоких урожаев. Цель исследования достигнута, выявлены наиболее эффективные протравители для яровой пшеницы. Сформулированные в результате исследования выводы и рекомендации, могут быть использованы для улучшения технологий производства пшеницы и повышения ее устойчивости к болезням, что в конечном итоге приведет к увеличению урожайности и обеспечению продовольственной безопасности.
Жаздык буудайлардын негизги оорулардын жугузуучулугуна уруктарды себүүнүн алдында дарылоо ыкмаларынын таасирин изилдөө айыл чарба практикасынын маанилүү аспектиси болуп саналат. Оорулардын натыйжасында болуп жаткан олуттуу жоготууларды эске алып, уруктарды дарылоонун ар кандай ыкмаларын изилдөөнүн натыйжалуулугун изилдөө буудайдын ооруларга туруктуулугун жана жогорку түшүмдү камсыз кылууда зор мааниси бар. Изилдөө максатына жетти – күздүк жана жаздык буудайлар үчүн натыйжалуу ууланткычтар табылды. Изилдөөнүн натыйжасында аныкталган корутундулар жана сунуштар буудайды өндүрүү технологиясын жакшыртуу жана анын ооруларга туруктуулугун жогорулатуу үчүн колдонулса болот. Бул натыйжада түшүмдүүлүгүн жогорулатууга жана азык-түлүк коопсуздугун камсыз кылууга алып келет.
The study of the influence of pre-sowing seed treatment methods on the incidence of winter and spring wheat by major diseases is an important aspect of agricultural practice. Given the significant crop losses caused by diseases, studying the effectiveness of various seed treatment methods is of great importance for increasing wheat resistance to diseases and ensuring high yields. The purpose of the study has been achieved – the most effective mordants for winter and spring wheat have been identified. The conclusions and recommendations formulated as a result of the study can be used to improve wheat production technologies and increase its resistance to diseases, which ultimately will lead to increased yields and food security.