bluuebunny/crossref_metadata_2025_split huggingface dataset:
LAM Test: A New Cognitive Marker for Early Detection in Preclinical Alzheimer’s Disease
Authors: García-Martínez María , Pozueta-Cantudo Ana , Lage Carmen , Martínez-Dubarbie Francisco , López-García Sara , Fernández-Matarrubia Marta , Corrales-Pardo Andrea , Bravo María , Cavada Nadia C. , Anuarbe Pedro , Infante Jon , López-Higuera José Miguel , Rodríguez-Cobo Luis , Rodríguez-Rodríguez Eloy , Butler Christopher R. , Sánchez-Juan Pascual 
Published: June 2024

Background: With the arrival of disease-modifying treatments, it is mandatory to find new cognitive markers that are sensitive to Alzheimer’s disease (AD) pathology in preclinical stages. Objective: To determine the utility of a newly developed Learning and Associative Memory face test: LAM test. This study examined the relationship between AD cerebrospinal fluid (CSF) biomarkers and performance on LAM test, and assessed its potential clinical applicability to detect subtle changes in cognitively healthy subjects at risk for AD. Methods: We studied eighty cognitively healthy volunteers from the Valdecilla cohort. 61% were women and the mean age was 67.34 years (±6.416). All participants underwent a lumbar puncture for determination of CSF biomarkers and an extensive neuropsychological assessment, including performance on learning and associative memory indices of the LAM-test after 30 min and after 1 week, and two classic word lists to assess verbal episodic memory: the Rey Auditory Verbal Learning Test (RAVLT) and the Free and Cued Selective Reminding Test (FCSRT). We analyzed cognitive performance according to amyloid status (A+ versus A–) and to ATN model (A–T–N–; A+T–N–; A+T+N–/A+T+N+). Results: Performance on the LAM-test was significantly correlated with CSF Aβ ratio. A+ participants performed worse on both learning (mean difference = 2.19, p = 0.002) and memory LAM measures than A– (mean difference = 2.19, p = 0.004). A decline in performance was observed along the Alzheimer’s continuum, with significant differences between ATN groups. Conclusions: Our findings suggest that LAM test could be a useful tool for the early detection of subjects within the AD continuum, outperforming classical memory tests.
Natural Health Products for Symptomatic Relief of Parkinson’s Disease: Prevalence, Interest, and Awareness
Authors: Diadhiou Sandra , Maas Bart R. , Schootemeijer Sabine , Bloem Bastiaan R. , de Vries Nienke M. , Calon Frédéric , Darweesh Sirwan K.L. , de Rus Jacquet Aurelie 
Published: June 2024

Background: Natural health products have emerged as a potential symptomatic therapeutic approach for people with Parkinson’s disease (PD). Objective: To determine the prevalence of natural health product use, interest in natural health products, awareness of potential herb-drug interactions, and consultation of healthcare professionals regarding natural health products use among people with PD. Methods: Cross-sectional 4-item survey embedded in the PRIME-NL study, which is a population-based cohort of PD. Results: Of 367 people with PD, 36% reported having used natural health products to alleviate PD-related symptoms, with coffee, cannabis and turmeric being the most popular. Furthermore, 71% of people with PD were interested in learning more about natural health products. 39% of natural health products users were aware that these products could interact with PD medication and 39% had discussed their use with their healthcare professional. Conclusions: Natural health products are commonly used to alleviate symptoms by people with PD, but most users are unaware that these products can interact with PD medication and do not discuss their consumption with their healthcare professional.
Pendampingan Keluarga Melalui Program Parenting Untuk Menekan Angka Stunting Di Kabupaten Cirebon
Authors: Hatimah Ihat , Yunus Lutfiansyah Dadang 
Published: June 2024

Pencegahan stunting tidak hanya tanggung jawab pemerintah saja, tetapi merupakan tanggung jawab semua pihak, termasuk masyarakat di dalamnya. Pola pikir masyarakat harus diubah dalam menangani stunting, salah satu upayanya dengan pemberian pendampingan/bimbingan terhadap keluarga tentang stunting dan permasalahannya. Sesungguhnya problematika stunting tidak terjadi pada keluarga yang tidak mampu saja tetapi pada keluarga mampu juga bisa terjadi, dan dapat terjadi baik di masyarakat perdesaan maupun masyarakat perkotaan. Berdasarkan permasalahan tersebut maka semua pihak harus ikut memikirkan untuk penurunan angka stunting tersebut. Perguruan Tinggi memiliki peran yang sangat penting dalam mengatasi permasalahan stunting, melalui Tri Dharma Perguruan Tinggi diharapkan dapat berpartisipasi dalam menurunkan angka stunting. Tujuan dari pengabdian kepada masyarakat ini adalah meningkatkan kesadaran orang tua dan memberikan pemahaman kepada keluarga tentang stunting, bahwa stunting tidak hanya masalah gizi, tetapi juga masalah air bersih, akses bahan pangan, pengelolaan keluarga, pernikahan dini. Metode pengabdian dilaksanakan berupa pendampingan terhadap keluarga, yang diawali dengan mengidentifikasi peta permasalahan stunting di Kabupaten Cirebon, dan melibatkan keluarga yang mempunyai anak stunting sebanyak 17 keluarga, dan didampingi oleh Tim di Lapangan. Simpulan dari kegiatan pendampingan keluarga adalah 1) Meningkatnya pengetahuan, sikap dan keterampilan orangtua mengenai program stunting dan pencegahannya, 2) Meningkatnya partisipasi orangtua pada program parenting yang dilaksanakan di satuan pendidikan, keluarga dan masyarakat (Posyandu, Pos KB dan sebagainya), 4) Terbentuknya pola pengasuhan keluarga yang berbasis pada tumbuh dan kembang anak yang mempertimbangkan asupan makanan yang bergizi dan seimbang agar tercipta keluarga yang bahagia, sejahtera dan berkualitas. Tindak lanjut dari kegiatan pengabdian ini adalah memperluas pola pendampingan untuk remaja tentang pencegahan stunting,
Pemberdayaan Perempuan Melalui Abon Kerang Dalam Mewujudkan Sdgs Di Era Digital Pada Komunitas Omak Kito Di Desa Bagan Asahan Baru
Authors: Rosramadhana Rosramadhana , Sudirman Sudirman , Nainggolan Erlin , Wardani Nur Azmi Siti , NW Manalu Magdalena , Ningsih Zulia 
Published: June 2024

Kerang merupakan jenis hewan yang memiliki cangkang yang memiliki daging tersembunyi dibalik sepasang cangkang tersebut (interverbrate moluska). Kerang merupakan bahan pangan yang bersumber dari perairan Indonesia yang tentunya memiliki aneka macam zat gizi yang berguna bagi tubuh. Namun, tidak sedikit masyarakat sekitar pesisir pantai yang mengetahui sekian banyak gizi yang terkandung dalamnya dan tidak mengetahui cara mengelola kerang tersebut jadi produk yang menarik. Salah satunya ialah Komunitas Omak Kito yang terdiri dari para perempuan yang merupakan istri dan anak nelayan di desa Bagan Asahan Baru. Metode pelaksanaan yang kami lakukan dalam pemberdayaan perempuan nelayan mengenai pembuatan abon kerang terdiri dari 3 tahapan, yaitu penyuluhan, pelatihan, dan pendampingan IPTEK. Tim PKM-PM berusaha melakukan kegiatan tersebut secara luring, namun karena situasi yang tidak memungkinkan. Tim PKM-PM melakukan kegiatan tersebut secara blended. Tujuan pengabdian ini yaitu untuk mewujudkan SDGs masyarakat desa Bagan Asahan Baru khususnya pada poin “Mencapai Kesetaraan Gender dan Upaya Memberdayakan Seluruh Perempuan dan Anak Perempuan”. Selain itu, diharapkan setelah kegiatan ini, dapat mendukung pertumbuhan perekonomian masyarakat desa Bagan Asahan Baru yang inklusif dan berkelanjutan, seperti tujuan SDGs yang ke-8. Potensi yang dihasilkan dari pembuatan abon kerang didukung dengan lokasi desa Bagan Asahan Baru yang dekat dengan objek wisata yaitu Pantai Panton. Jadi dengan melihat potensi daerah wisata yang ada, maka produk abon kerang dari masyarakat desa Bagan Asahan Baru ini dapat menjadi buah tangan dari Pantai Panton tersebut dan menjadikannya sebagai camilan khas daerah tersebut.
Pembelajaran Menulis Teks Puisi Berbasis Model Akrostik dengan Kartu Kata melalui Media Wordwall
Authors: Mauluddin Imam , Zahro Azizatuz , Widyartono Didin 
Published: June 2024

Penelitian ini bertujuan untuk mengembangkan konsep pembelajaran menulis teks puisi berbasis model akrostik dengan kartu kata melalui media wordwall. Penelitian ini menggunakan metode studi literatur atau studi kepustakaan. Studi kepustakaan berkaitan dengan kajian-kajian teoritis yang menggunaan beberapa referensi yang tidak terlepas dari literatur-literatur ilmiah tentang menulis teks puisi berbasis model akrostik dengan kartu kata melalui media wordwall. Hasil dari pengembangan konsep pembelajaran menulis teks puisi berbasis model akrostik dengan kartu melalui media wordwall terdapat pemanfaatan wordwall sebagai media pembelajaran, prosedur pembelajaran menulis teks puisi berbasis model akrostik dengan kartu kata melalui media wordwall, keefektifan pembelajaran menulis puisi berbasis akrostik dengan media wordwall, contoh rancangan menulis puisi melalui kartu kata dengan media wordwall.
Dampak Kebijakan Akuisisi Terhadap Berlangsungnya Kegiatan Di Pasar Turi Baru
Authors: Chrisanty Rachel Zefanya , Harmawan Bagus Nuari 
Published: June 2024

Permasalahan yang terjadi di Pasar Turi Baru tergolong dalam permasalahan kompleks. Permasalahan tersebut adalah tentang kurangnya minat pengunjung untuk melakukan kegiatan jual-beli yang diakibatkan oleh banyaknya toko yang belum buka di Pasar Turi Baru. Sehingga manajemen mengambil langkah untuk mengimplementasikan kebijakan yakni akuisisi untuk menangani permasalahan tersebut. Penelitian ini bertujuan untuk mengetahui dampak yang dirasakan oleh elemen-elemen terlibat dari upaya implementasi kebijakan akuisisi yang dibuat pihak manajemen. Penulisan ini menggunakan metode kualitatif deskriptif. Penulis menggunakan acuan indeks teori dampak kebijakan yang disampaikan Thomas Dye (1981) yang dikutip oleh Pandu Pratomo, dkk (2013) yang mengungkapkan beberapa aspek penting yang harus diperhatikan dalam pengukuran dampak suatu kebijakan, yaitu dampak kebijakan terhadap kelompok target, dampak kebijakan terhadap kelompok lain diluar sasaran atau yang sering disebut dengan eksternalitas, dampak kebijakan terhadap kondisi sekarang dan kondisi yang akan datang, dampak biaya langsung yang dikeluarkan untuk membiayai program, dampak tak langsung yang dikeluarkan publik sebagai akibat diterapkannya suatu kebijakan.

Kata kunci : Akuisisi, Dampak, Pedagang Pasar Turi Baru
Loneliness and social isolation: exploring the experiences of older women during the pandemic in terms of social connection, feeling of loneliness, and the impact on mental health and wellbeing
Authors: Bhat Nasrullah , Paul Fayaz Ahmad , Gul Aamir , Ganie Zahoor Ahmad 
Published: June 2024

ObjectivesTo investigate the unique challenges faced by older women during the COVID-19 pandemic regarding social connection, feelings of loneliness, and their subsequent impact on mental health and well-being.MethodA qualitative research methodology is used to examine how older women experienced loneliness, social relationships, and mental health consequences during the COVID-19 pandemic.ResultsThe results are discussed in terms of two main themes each with their sub-themes; 1. Social Connection amidst Physical Distancing Measures, 2. Impact on Mental Health and Well-being.ConclusionThe study highlights the significant impact of loneliness and social isolation on the mental health of older women during the COVID-19 pandemic, emphasizing the need for targeted interventions and support systems.
Association of obstructive sleep apnea syndrome with polycystic ovary syndrome through bidirectional Mendelian randomization
Authors: Liu Peijun , Zhang Qin , Ding Haitao , Zou Hua 
Published: June 2024

BackgroundObservational studies have established a link between polycystic ovary syndrome (PCOS) and obstructive sleep apnea syndrome (OSAS), with obesity being a significant confounding factor that complicates the understanding of causality. This study seeks to clarify the causal relationship by utilizing bidirectional two-sample Mendelian randomization (MR) analysis.MethodsA bidirectional MR strategy was implemented to investigate the potential causal relationship between PCOS and OSAS. Instrumental variables (IVs) for PCOS were sourced from a dataset comprising 3,609 cases and 229,788 controls. For OSAS, statistical data were obtained from a genome-wide association study (GWAS) involving 38,998 subjects, alongside a control group of 336,659 individuals. Our MR analysis utilized several methods, including inverse variance weighted (IVW), weighted mode, weighted median, simple mode, and MR-Egger, primarily focusing on the IVW technique. Sensitivity tests were conducted to ensure the robustness of our findings.ResultsUtilizing the IVW method, we identified a notable causal association from OSAS to PCOS, with an odds ratio (OR) of 1.463 and a 95% confidence interval (CI) of 1.086–1.971 (p = 0.012). In the opposite direction, PCOS also appeared to significantly affect OSAS development, indicated by an OR of 1.041 and a 95% CI of 1.012–1.072 (p = 0.006). The MR-Egger intercept test showed no evidence of directional pleiotropy, affirming the credibility of our causal findings (p &gt; 0.05).ConclusionThis study suggests a bidirectional causal relationship between PCOS and an increased risk of OSAS. These insights could guide future screening and prevention strategies for both conditions.
Changes in the gut microbiota of patients with sarcopenia based on 16S rRNA gene sequencing: a systematic review and meta-analysis
Authors: Song Qi , Zhu Youkang , Liu Xiao , Liu Hai , Zhao Xinyi , Xue Liyun , Yang Shaoying , Wang Yujia , Liu Xifang 
Published: June 2024

IntroductionSarcopenia, an age-related disease, has become a major public health concern, threatening muscle health and daily functioning in older adults around the world. Changes in the gut microbiota can affect skeletal muscle metabolism, but the exact association is unclear. The richness of gut microbiota refers to the number of different species in a sample, while diversity not only considers the number of species but also the evenness of their abundances. Alpha diversity is a comprehensive metric that measures both the number of different species (richness) and the evenness of their abundances, thereby providing a thorough understanding of the species composition and structure of a community.MethodsThis meta-analysis explored the differences in intestinal microbiota diversity and richness between populations with sarcopenia and non-sarcopenia based on 16 s rRNA gene sequencing and identified new targets for the prevention and treatment of sarcopenia. PubMed, Embase, Web of Science, and Google Scholar databases were searched for cross-sectional studies on the differences in gut microbiota between sarcopenia and non-sarcopenia published from 1995 to September 2023 scale and funnel plot analysis assessed the risk of bias, and performed a meta-analysis with State v.15. 1.ResultsA total of 17 randomized controlled studies were included, involving 4,307 participants aged 43 to 87 years. The alpha diversity of intestinal flora in the sarcopenia group was significantly reduced compared to the non-sarcopenia group: At the richness level, the proportion of Actinobacteria and Fusobacteria decreased, although there was no significant change in other phyla. At the genus level, the abundance of f-Ruminococcaceae; g-Faecalibacterium, g-Prevotella, Lachnoclostridium, and other genera decreased, whereas the abundance of g-Bacteroides, Parabacteroides, and Shigella increased.DiscussionThis study showed that the richness of the gut microbiota decreased with age in patients with sarcopenia. Furthermore, the relative abundance of different microbiota changed related to age, comorbidity, participation in protein metabolism, and other factors. This study provides new ideas for targeting the gut microbiota for the prevention and treatment of sarcopenia.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=475887, CRD475887.
Structure-based screening of FDA-approved drugs identifies potential histone deacetylase 3 repurposed inhibitor: molecular docking and molecular dynamic simulation approaches
Authors: Shamsi Anas , Khan Mohd Shahnawaz , Yadav Dharmendra Kumar , Shahwan Moyad 
Published: June 2024

Histone deacetylase 3 (HDAC3) is a member of the histone deacetylase family that has emerged as a crucial target in the quest for novel therapeutic interventions against various complex diseases, including cancer. The repositioning of FDA-approved drugs presents a promising avenue for the rapid discovery of potential HDAC3 inhibitors. In this study, we performed a structure-based virtual screening of FDA-approved drugs obtained from DrugBank. Candidate hits were selected based on their binding affinities and interactions with HDAC3. These promising hits were then subjected to a comprehensive assessment of their biological properties and drug profiles. Our investigation identified two FDA-approved drugs, Imatinib and Carpipramine, characterized by their exceptional affinity and specificity for the binding pocket of HDAC3. These molecules demonstrated a strong preference for HDAC3 binding site and formed interactions with functionally significant residues within the active site pocket. To gain deeper insights into the binding dynamics, structural stability, and interaction mechanisms, we performed molecular dynamics (MD) simulations spanning 300 nanoseconds (ns). The results of MD simulations indicated that Imatinib and Carpipramine stabilized the structure of HDAC3 and induced fewer conformational changes. Taken together, the findings from this study suggest that Imatinib and Carpipramine may offer significant therapeutic potential for treating complex diseases, especially cancer.
Artemisia smithii patches form fertile islands and lead to heterogeneity of soil bacteria and fungi within and around the patches in alpine meadows of the Qinghai-Tibetan Plateau
Authors: Yang Hang , Yu Xiaojun , Song Jianchao , Wu Jianshuang 
Published: June 2024

Herbivore-avoided plant patches are one of the initial characteristics of natural grassland degradation. These vegetation patches can intensify the spatial heterogeneity of soil nutrients within these grasslands. However, the effects of non-edible plant patches patches on the spatial heterogeneity of microorganisms have not been sufficiently studied in alpine meadows of the Qinghai-Tibetan Plateau, especially patches formed by herbaceous plants. To answer this question, soil nutrients, plant assembly, and microbial communities were measured inside, around, and outside of Artemisia smithii patches. These were 0 m (within the patch), 0–1 m (one meter from the edge of the patch), 1–2 m (two meters from the edge of the patch), 2–3 m (three meters from the edge of the patch), and &gt;30 m (non-patch grassland more than thirty meters from the edge of the patch). Our results showed that A. smithii patches accumulated more aboveground biomass (AGB) within the patches (0 m), and formed fertile islands with the soil around the patches. Additionally, A. smithii patches increased soil bacterial diversity within (0 m) and around (0–1 m) the patches by primarily enriching copiotrophic bacteria (Actinobacteria), while the diversity of fungal communities increased mainly in the 0–1 m area but not within the patches. Bacterial community diversity was driven by pH, urease, nitrate nitrogen (NO3−-N), and microbial biomass carbon (MBC). The contents of soil water (SWC), soil organic matter (SOM), urease, NO3−-N, and MBC were the main factors influencing the diversity of the fungal community. This study elucidates the vegetation, nutrients, and microbial heterogeneity and their interrelationships, which are observed in fertile islands of herbivore-avoided plant patches in alpine meadows, and provides further insights into the spatial pattern of nutrients in patchy degraded grasslands.
Alone but not isolated: social presence and cognitive load in learning with 360 virtual reality videos
Authors: Ki Suhyun , Park Sanghoon , Ryu Jeeheon , Kim Jongho , Kim Inki 
Published: June 2024

IntroductionThis study aimed to identify any differences in social presence and cognitive load among three types of 360 virtual reality (VR)-based videos lectures. We hypothesized that social presence would be higher when interactions among peers are visible in a 360 VR video lectures while the cognitive load would be also increased.MethodsA total of 48 college students were randomly assigned to one of the three study groups to view an assigned 360 VR video lecture. The three groups were: (1) an instructor-only video viewing group, (2) a classroom lecture video viewing group, and (3) a classroom lecture and activity video viewing group. The video lectures were differently designed depending on the levels of peer visibility and the interactions between the instructor and peers. The participants watched one of the three types of assigned video lecture and subsequently completed two sets of questionnaires regarding social presence and cognitive load. A multivariate analysis of variance (MANOVA) was conducted with a planned contrast analysis for the type of video lectures.ResultsWe found that, contrary to the hypotheses, students in the group 1 (instructor-only video) showed higher social presence scores than students in the groups 2 and 3. However, no significant differences were found in the cognitive load scores.DiscussionThe results show that 360 VR video lectures with an instructor-only are more effective at enhancing users’ social presence than 360 VR video lectures with both the instructor and class-peers. We suggest creating 360 VR video lectures with the presence of the course instructor to offer learners the sense of actually participating in a lecture.
Higher homocysteine and fibrinogen are associated with early-onset post-stroke depression in patients with acute ischemic stroke
Authors: Deng Mingzhu , Zhou Nina , Song Kangping , Wang Zhen , Zhao Wei , Guo Jiayu , Chen Sufen , Tong Yangping , Xu Wei , Li Fangyi 
Published: June 2024

BackgroundPost-stroke depression (PSD) is a well-established psychiatric complication following stroke. Nevertheless, the relationship between early-onset PSD and homocysteine (Hcy) or fibrinogen remains uncertain.MethodsAcute ischemic stroke (AIS) patients who met the established criteria were enrolled in this study. Early-onset PSD was diagnosed two weeks after the stroke. The severity of depressive symptoms was assessed by the Hamilton Depression Scale-17 items (HAMD-17), with patients scored ≥7 assigned to the early-onset PSD group. Spearman rank correlation analysis was employed to evaluate the associations between Hcy, fibrinogen, and HAMD scores across all patients. Logistic regression analysis was conducted to investigate the relationship between Hcy, fibrinogen, and early-onset PSD. Receiver operating characteristic curve (ROC) analysis was ASSDalso performed to detect the predictive ability of Hcy and fibrinogen for early-onset PSD.ResultsAmong the 380 recruited patients, a total of 106 (27.89%) patients were diagnosed with early-onset PSD. The univariate analysis suggested that patients in the PSD group had a higher admission National Institutes of Health Stroke Scale (NIHSS) score, modified Rankin Scale score (mRS), Hcy, and fibrinogen levels than patients in the non-PSD group (P&lt;0.05). The logistic regression model indicated that Hcy (odds ratio [OR], 1.344; 95% confidence interval [CI] 1.209–1.494, P&lt;0.001) and fibrinogen (OR, 1.57 6; 95% CI 1.302–1.985, P&lt;0.001) were independently related to early-onset PSD. Area under curve (AUC) of Hcy, fibrinogen, and Hcy combined fibrinogen to predict early-onset PSD was 0.754, 0.698, and 0.803, respectively.ConclusionThis study indicates that Hcy and fibrinogen may be independent risk factors for early-onset PSD and can be used as predictive indicators for early-onset PSD.