bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Analysis of the Temporal Evolution of ENSO Prediction Skill in the Context of the Equatorial Pacific Ocean Observing System
Authors: Kumar Arun , Chen Mingyue , Xue Yan , Behringer David 
Published: May 2015

Abstract
Subsurface ocean observations in the equatorial tropical Pacific Ocean dramatically increased after the 1990s because of the completion of the TAO moored array and a steady increase in Argo floats. In this analysis the question explored is whether a steady increase in ocean observations can be discerned in improvements in skill of predicting sea surface temperature (SST) variability associated with El Niño–Southern Oscillation (ENSO)? The analysis is based on the time evolution of skill of sea surface temperatures in the equatorial tropical Pacific since 1982 based on a seasonal prediction system. It is found that for forecasts up to a 6-month lead time, a clear fingerprint of increases in subsurface ocean observations is not readily apparent in the time evolution of prediction skill that is dominated much more by the signal-to-noise consideration of SSTs to be predicted. Finding no clear relationship between an increase in ocean observations and prediction skill of SSTs, various possibilities for why it may be so are discussed. This discussion is to motivate further exploration on the question of the tropical Pacific observing system, its influence on the skill of ENSO prediction, and the capabilities of the current generation of coupled models and ocean data assimilation systems to take advantage of ocean observations.
Intimate Strangers: The Role of the Hospital Chaplain in Situations of Sudden Traumatic Loss
Authors: Dykstra Robert C. 
Published: May 2015

Discusses the role of the hospital chaplain in situations of sudden traumatic loss making extensive use of the metaphore of the Stranger. Explicates biblical, theological, historical, and psychological perspectives on the metaphore as it appears within the Judeo-Christian tradition and critically relates this to much current crisis literature. Notes how hospital traumas demonstrate to the chaplain how God's presence may be witnessed in the strange and in ways not always placid or traditional. An eighteen-year-old high school senior, whose mother was a cancer patient only days away from death in a distant urban hospital, was at home alone with his father when the father began complaining of chest pains. He asked his son to drive him to the local emergency hospital, about twenty minutes away. The young man wisely refused, instead insisting on calling an ambulance. En route to the hospital, the father suffered a severe heart attack. When the ambulance arrived at the emergency room, the father, only hours before a vigorous and robust man, now was teetering critically on the edge of life and death. As a chaplain in the hospital, I was called by a nurse to wait with the son. I found him with tears streaming down his face, his hands visibly shaking. While he had begun to prepare himself for his mother's pending death, the sudden possibility of at once losing both parents terrified and overwhelmed him. The young man's only sister—a college student—lived in a city hours away, as did any of the nearest relatives of the family. He could think of no family friends who could be asked to support him there. His parish priest was out of town. The tension-filled five or six hours we waited together for relatives to arrive, during which the father experienced two more heart attacks, were among the most agonizing moments I have had in ministry.
A Pastoral Response to Society's Polarization
Authors: Frazier Richard T. 
Published: May 2015

Expresses a personal sadness over America society's current tendencies to polarize moral positions along extreme lines. Offers a pastoral response to such polarization tendencies by drawing upon prophetic traditions of both Judaism and Christianity. Offers some practical guidelines for pastoral caregivers, recognizing the inevitable ambiguities that accompany the search for God and for personal meaning within the complex realities and dynamics of a rapidly changing world. Randall Terry [spokesman for the pro-life organization Operation Rescue]: “The bottom line is that killing children is not what America is all about. We are not here to destroy our offspring.” Fay Wattleton [president of Planned Parenthood]: “Well, we are also not here to have the government use women's bodies as the instrument of the state, to force women into involuntary servitude—” Randall Terry (laughing): “Oh come on Faye.” Faye Wattleton: “I think that as Americans celebrate the Fourth of July, our independence, and when we reflect on our personal liberties, this is a very, very somber time, in which the courts have said that the most private aspects of our lives are now … not protected by the Bill of Rights and the Constitution. And I believe that that is a time for Americans to reflect on the need to return to the fundamentals, and the fundamentals of personal privacy are really the cornerstones upon which our democracy is built.” Randall Terry: “I think that to assume or even suggest that the founding fathers of this country risked their lives and many of them died so that we can kill our offspring is pathetic.”
The Family God Intends
Authors: Howe Leroy T. 
Published: May 2015

Summarizes what the author considers the best visions of the family within a Christian framework. Claims that, given the many modern threats to the authentic family, ministry to family members continues to remain a vital center for all pastoral care. …near the cross on which Jesus hung, his mother was standing with sister, Mary wife of Eleopas, and Mary of Magdala. Seeing his mother, with the disciple whom he loved standing beside her, Jesus said to her, “Mother, there is your son”; and to the disciples, “There is your mother”; and from that moment the disciple took her into his home.” ( John 19:25–27, REB)
Clonidine as an adjuvant in the management of acute poisoning by anticholinesterase pesticides
Authors: El-Ebiary AA , Gad SA , Wahdan AA , El-Mehallawi IH 
Published: May 2015

Introduction: Anticholinesterase pesticides are widely used in agriculture and domestic settings throughout the world, and they are responsible for great morbidity and mortality. In Egypt and other developing countries, there is a pressing need for new affordable antidotes to treat anticholinesterase pesticide poisoning. Hence, this study was conducted to evaluate the safety and effectiveness of moderate doses of clonidine in the management of adult patients with acute anticholinesterase pesticide poisoning. Methodology: This study was an open-label, phase II pilot clinical trial. Sixty patients with acute anticholinesterase pesticide poisoning gave consent to participate in the study. They were divided into 2 equal groups, with 30 patients in each group. Group I received clonidine plus the routine treatment, while group II received only the routine treatment. Patients were subjected to full history taking, and their vital and clinical data were recorded. Serum cholinesterase levels and routine laboratory investigations were measured. The different outcomes of the patients were assessed. Results: The baseline characteristics of both groups were similar. Thirteen (43.3%) patients developed significant hypotension during clonidine treatment. The clinical outcomes (including mortality, need for assisted ventilation, length of hospital stay, and total doses of atropine) showed no significant differences between the two groups. Conclusion: The use of clonidine in acute anticholinesterase pesticide poisoning may be associated with a high incidence of hypotension requiring intervention. The clinical outcomes may not significantly improve in clonidine-treated patients.
Non-melanoma Skin Cancer in Canada Chapter 4: Management of Basal Cell Carcinoma
Authors: Zloty David , Guenther Lyn C. , Sapijaszko Mariusz , Barber Kirk , Claveau Joël , Adamek Tamara , Cancer John Ashkenas ,   Guidelines Committee
Published: May 2015

Background Basal cell carcinoma (BCC) is the most common malignancy. Growth of BCCs leads to local destruction of neighbouring healthy skin and underlying tissue and can result in significant functional and cosmetic morbidity. Objective To provide guidance to Canadian health care practitioners regarding management of BCCs. Methods Literature searches and development of graded recommendations were carried out as discussed in the accompanying Introduction. Results Although BCCs rarely metastasize“ they can be aggressive and disfiguring. This chapter describes the natural history and prognosis of BCCs. Risk stratification is based on clinical features” including the site and size of the tumour“ its histologic subtype (nodular vs sclerosing)” and its history of recurrence. Conclusions Various options should be considered for BCC treatment” including cryosurgery” curettage” and topical or photodynamic approaches, as well as fixed-margin surgery and Mohs micrographic surgery. Stratification of recurrence risk for individual BCCs determines the most appropriate therapeutic course.
Intravascular Ultrasound Measurements After Drug-Eluting Stent Placement in Femoropopliteal Lesions
Authors: Mori Shinsuke , Hirano Keisuke , Nakano Masatsugu , Muramatsu Toshiya , Tsukahara Reiko , Ito Yoshiaki , Ishimori Hiroshi 
Published: May 2015

Purpose: To investigate the relationship between postprocedure intravascular ultrasound (IVUS) findings and restenosis after placement of drug-eluting stents (DES) for femoropopliteal lesions. Methods: Between July 2012 and May 2013, DES were placed in 64 patients with 88 de novo femoropopliteal lesions. In 40 patients (mean age 74.2±9.4 years; 27 men), DES were placed in 50 lesions under IVUS guidance, and restenosis was monitored for 1 year. All patients were symptomatic (Rutherford 2–6), and 17 patients (43%) suffered from critical limb ischemia. IVUS findings after stenting were compared for patients with vs without restenosis, which was defined as a peak systolic velocity ratio >2.4 on duplex ultrasonography or >50% diameter stenosis on angiography. Results: Ten patients (14 lesions) developed restenosis, while 30 patients (36 lesions) did not. There were no significant differences in the frequency of diabetes or dialysis between the 2 groups. Female patients were predominant in the restenosis group (p<0.003). There were no significant differences of the percentage of TransAtlantic Inter-Society Consensus C/D lesions or stent edge dissection. Multivariate analysis indicated that cilostazol use [odds ratio (OR) 0.13; p=0.046], distal lumen cross-sectional area (CSA) (OR 0.86; p=0.035), and axial symmetry index (OR 0.60; p=0.045) were independent predictors of restenosis. Using receiver operator characteristic analysis, the best cutoff values of the distal lumen CSA and axial symmetry index for predicting restenosis were 17.1 cm2 and 0.6, respectively. Conclusion: IVUS guidance of DES placement in femoropopliteal lesions can offer useful predictors of restenosis at 1 year. The utility of distal lumen CSA and the axial symmetry index in the prediction of restenosis after femoropopliteal DES placement should be confirmed in a larger cohort.
Liberation Psychological Implications for Pastoral Care of Korean Military Wives
Authors: Chang Bocheol 
Published: May 2015

Native Korean women frequently suffer poverty, sexual violence, and Confucian gender discrimination. Once in America Korean military wives also experience racial and sexual oppression, intercultural familial conflicts and violence, and identity crisis and lead to feelings of isolation and non-belonging, a sense of anomie. Korean American pastors tend to understate and oversimplify the complexity of psychological and spiritual suffering of Korean military wives and overemphasize individual faith development as a solution. Liberation psychology evolved from an awareness of similar dehumanizing realities. The context-based perspective of liberation psychology offers a model to interpret and assist in the psychological and spiritual healing of Korean military wives The healing power of conscientization offered in Liberation psychology for oppressed individuals encourages self-awakening suggesting it as an ideal interventional model to help Korean military wives and would be a useful approach for Korean American pastors.
Development and Validation of a Rapid 13C6-Glucose Isotope Dilution UPLC-MRM Mass Spectrometry Method for Use in Determining System Accuracy and Performance of Blood Glucose Monitoring Devices
Authors: Matsunami Risë K. , Angelides Kimon , Engler David A. 
Published: May 2015

Background: There is currently considerable discussion about the accuracy of blood glucose concentrations determined by personal blood glucose monitoring systems (BGMS). To date, the FDA has allowed new BGMS to demonstrate accuracy in reference to other glucose measurement systems that use the same or similar enzymatic-based methods to determine glucose concentration. These types of reference measurement procedures are only comparative in nature and are subject to the same potential sources of error in measurement and system perturbations as the device under evaluation. It would be ideal to have a completely orthogonal primary method that could serve as a true standard reference measurement procedure for establishing the accuracy of new BGMS. Methods: An isotope-dilution liquid chromatography/mass spectrometry (ID-UPLC-MRM) assay was developed using 13C6-glucose as a stable isotope analogue to specifically measure glucose concentration in human plasma, and validated for use against NIST standard reference materials, and against fresh isolates of whole blood and plasma into which exogenous glucose had been spiked. Assay performance was quantified to NIST-traceable dry weight measures for both glucose and 13C6-glucose. Results: The newly developed assay method was shown to be rapid, highly specific, sensitive, accurate, and precise for measuring plasma glucose levels. The assay displayed sufficient dynamic range and linearity to measure across the range of both normal and diabetic blood glucose levels. Assay performance was measured to within the same uncertainty levels (<1%) as the NIST definitive method for glucose measurement in human serum. Conclusions: The newly developed ID UPLC-MRM assay can serve as a validated reference measurement procedure to which new BGMS can be assessed for glucose measurement performance.
Current Concepts in Hip Preservation Surgery
Authors: Adler Kelly L. , Cook P. Christopher , Yen Yi-Meng , Giordano Brian D. 
Published: May 2015

Context: An evolution in conceptual understanding, coupled with technical innovations, has enabled hip preservation surgeons to address complex pathomorphologies about the hip joint to reduce pain, optimize function, and potentially increase the longevity of the native hip joint. Technical aspects of hip preservation surgeries are diverse and range from isolated arthroscopic or open procedures to hybrid procedures that combine the advantages of arthroscopy with open surgical dislocation, pelvic and/or proximal femoral osteotomy, and biologic treatments for cartilage restoration. Evidence Acquisition: PubMed and CINAHL databases were searched to identify relevant scientific and review articles from January 1920 to January 2015 using the search terms hip preservation, labrum, surgical dislocation, femoroacetabular impingement, peri-acetabular osteotomy, and rotational osteotomy. Reference lists of included articles were reviewed to locate additional references of interest. Study Design: Clinical review. Level of Evidence: Level 4. Results: Thoughtful individualized surgical procedures are available to optimize the femoroacetabular joint in the presence of hip dysfunction. Conclusion: A comprehensive understanding of the relationship between femoral and pelvic orientation, morphology, and the development of intra-articular abnormalities is necessary to formulate a patient-specific approach to treatment with potential for a successful long-term result.
Introducing Acceptance and Commitment Therapy to a physiotherapy-led pain rehabilitation programme: an Action Research study
Authors: Barker Karen L , Heelas Leila , Toye Francine 
Published: May 2015

Background: Recent developments in pain rehabilitation emphasise the importance of promoting psychological flexibility. Acceptance and Commitment Therapy (ACT) is one approach that has been shown to be effective for the treatment of chronic musculoskeletal pain. However, studies have shown that introducing innovative approaches such as ACT into established health care can cause some anxiety for professional groups. We used Action Research to evaluate the implementation of ACT to a physiotherapy-led pain rehabilitation programme. Methods: All staff in the pain service were invited to participate. Participants took part in focus groups, engaged in reflective sessions/meetings and completed reflective diaries. The analysis was undertaken by an experienced qualitative researcher using constant comparison. Participants reviewed emerging themes and validated the findings. Results: Four key themes emerged from the study: (a) the need to see pain as an embodied, rather than dualistic, experience; (b) the need for a more therapeutic construction of ‘acceptance’; (c) value-based goals as profound motivation for positive change; and (d) it’s quite a long way from physiotherapy. Integral to a therapeutic definition of acceptance was the challenge of moving away from ‘fixing’ towards ‘sitting with’. Participants described this as uncomfortable because it did not fit their biomedical training. Conclusion: This article describes how Action Research methodology was used in the introduction of ACT to a physiotherapy-led pain rehabilitation programme. The innovation of this study is that it helps us to understand the potential barriers and facilitators to embedding an ACT philosophy within a physiotherapy setting.
Non-contrast-enhanced MR portography and hepatic venography with time-spatial labeling inversion pulses: comparison at 1.5 Tesla and 3 Tesla
Authors: Ohno Tsuyoshi , Isoda Hiroyoshi , Furuta Akihiro , Togashi Kaori 
Published: May 2015

Background A 3 Tesla (3 T) magnetic resonance (MR) scanner is a promising tool for upper abdominal MR angiography. However, there is no report focused on the image quality of non-contrast-enhanced MR portography and hepatic venography at 3 T. Purpose To compare and evaluate images of non-contrast-enhanced MR portography and hepatic venography with time-spatial labeling inversion pulses (Time-SLIP) at 1.5 Tesla (1.5 T) and 3 T. Material and Methods Twenty-five healthy volunteers were examined using respiratory-triggered three-dimensional balanced steady-state free-precession (bSSFP) with Time-SLIP. For portography, we used one tagging pulse (selective inversion recovery) and one non-selective inversion recovery pulse; for venography, two tagging pulses were used. The relative signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were quantified, and the quality of visualization was evaluated. Results The CNRs of the main portal vein, right portal vein, and left portal vein at 3 T were better than at 1.5 T. The image quality scores for the portal branches of segment 4, 5, and 8 were significantly higher at 3 T than at 1.5 T. The CNR of the right hepatic vein (RHV) at 3 T was significantly lower than at 1.5 T. The image quality scores of RHV and the middle hepatic vein were higher at 1.5 T than at 3 T. For RHV visualization, the difference was statistically significant. Conclusion Non-contrast-enhanced MR portography with Time-SLIP at 3 T significantly improved visualization of the peripheral branch in healthy volunteers compared with1.5 T. Non-contrast-enhanced MR hepatic venography at 1.5 T was better than at 3 T.
Plasma biomarkers of acute GVHD and nonrelapse mortality: predictive value of measurements before GVHD onset and treatment
Authors: McDonald George B. , Tabellini Laura , Storer Barry E. , Lawler Richard L. , Martin Paul J. , Hansen John A. 
Published: May 2015

Key PointsBefore GVHD treatment, informative plasma biomarkers included TIM3, IL6, sTNFR1 (for grade 3-4 GVHD), and ST2 and sTNFR1 (for NRM at 1 year). In a day 14 landmark analysis, plasma TIM3 was predictive of grade 3-4 GVHD.
An integrative analysis of post-translational histone modifications in the marine diatom Phaeodactylum tricornutum
Authors: Veluchamy Alaguraj , Rastogi Achal , Lin Xin , Lombard Bérangère , Murik Omer , Thomas Yann , Dingli Florent , Rivarola Maximo , Ott Sandra , Liu Xinyue , Sun Yezhou , Rabinowicz Pablo D. , McCarthy James , Allen Andrew E. , Loew Damarys , Bowler Chris , Tirichine Leïla 
Published: May 2015

Abstract
Background
Nucleosomes are the building blocks of chromatin where gene regulation takes place. Chromatin landscapes have been profiled for several species, providing insights into the fundamental mechanisms of chromatin-mediated transcriptional regulation of gene expression. However, knowledge is missing for several major and deep-branching eukaryotic groups, such as the Stramenopiles, which include the diatoms. Diatoms are highly diverse and ubiquitous species of phytoplankton that play a key role in global biogeochemical cycles. Dissecting chromatin-mediated regulation of genes in diatoms will help understand the ecological success of these organisms in contemporary oceans.

Results
Here, we use high resolution mass spectrometry to identify a full repertoire of post-translational modifications on histones of the marine diatom Phaeodactylum tricornutum, including eight novel modifications. We map five histone marks coupled with expression data and show that P. tricornutum displays both unique and broadly conserved chromatin features, reflecting the chimeric nature of its genome. Combinatorial analysis of histone marks and DNA methylation demonstrates the presence of an epigenetic code defining activating or repressive chromatin states. We further profile three specific histone marks under conditions of nitrate depletion and show that the histone code is dynamic and targets specific sets of genes.

Conclusions
This study is the first genome-wide characterization of the histone code from a stramenopile and a marine phytoplankton. The work represents an important initial step for understanding the evolutionary history of chromatin and how epigenetic modifications affect gene expression in response to environmental cues in marine environments.
A facile, stereoselective, one-pot synthesis of resveratrol derivatives
Authors: Birar Vishal C , Sheerin Angela N , Milkovicova Jana , Faragher Richard G A , Ostler Elizabeth L 
Published: May 2015

Abstract

Background
Compounds based on trans-1,2-diphenylethene are the subject of intense interest both for their optical properties and as potential leads for drug discovery, as a consequence of their anticancer, anti-inflammatory and antioxidant properties. Perhaps the best known of these is trans-3,5,4′-trihydroxystilbene (resveratrol), that has been identified as a promising lead in the search for anti-ageing therapeutics.

Results
We report here a new, convenient, one-pot stereo-selective synthesis of resveratrol and other trans-stilbene derivatives. A wide range of known and novel “Resveralogues” were synthesised by using this simple protocol, including examples with electron donating and electron withdrawing substituents, in uniformly high yield. The structures of all compounds were confirmed by standard methods including 1H and 13C NMR, IR and High Resolution Mass spectroscopy.

Conclusions
We have established a simple and convenient protocol for resveralogue synthesis. It is readily scalable, and sufficiently robust and simple for ready use in automated synthesis or for library development of resveralogues. This supersedes previously reported synthetic methods that required inert conditions, extensive purification and/or costly reagents.