bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soft resonator of omnidirectional resonance for acoustic metamaterials with a negative bulk modulus
Authors: Jing Xiaodong , Meng Yang , Sun Xiaofeng 
Published: November 2015

AbstractMonopolar resonance is of fundamental importance in the acoustic field. Here, we present the realization of a monopolar resonance that goes beyond the concept of Helmholtz resonators. The balloon-like soft resonator (SR) oscillates omnidirectionally and radiates from all parts of its spherical surface, eliminating the need for a hard wall for the cavity and baffle effects. For airborne sound, such a low-modulus resonator can be made extremely lightweight. Deep subwavelength resonance is achieved when the SR is tuned by adjusting the shell thickness, benefiting from the large density contrast between the shell material and the encapsulated gas. The SR resonates with near-perfect monopole symmetry, as demonstrated by the theoretical and experimental results, which are in excellent agreement. For a lattice of SRs, a band gap occurs and blocks near-total transmission and the effective bulk modulus exhibits a prominent negative band, while the effective mass density remains unchanged. Our study shows that the SR is suitable for building 3D acoustic metamaterials and provides a basis for constructing left-handed materials as a new means of creating a negative bulk modulus.
Involvement of opsins in mammalian sperm thermotaxis
Authors: Pérez-Cerezales Serafín , Boryshpolets Sergii , Afanzar Oshri , Brandis Alexander , Nevo Reinat , Kiss Vladimir , Eisenbach Michael 
Published: November 2015

AbstractA unique characteristic of mammalian sperm thermotaxis is extreme temperature sensitivity, manifested by the capacity of spermatozoa to respond to temperature changes of <0.0006 °C as they swim their body-length distance. The identity of the sensing system that confers this exceptional sensitivity on spermatozoa is not known. Here we show that the temperature-sensing system of mammalian spermatozoa involves opsins, known to be G-protein-coupled receptors that act as photosensors in vision. We demonstrate by molecular, immunological and functional approaches that opsins are present in human and mouse spermatozoa at specific sites, which depend on the species and the opsin type and that they are involved in sperm thermotaxis via two signalling pathways—the phospholipase C and the cyclic-nucleotide pathways. Our results suggest that, depending on the context and the tissue, mammalian opsins act not only as photosensors but also as thermosensors.
Emergence of Hemagglutinin Mutations During the Course of Influenza Infection
Authors: Cushing Anna , Kamali Amanda , Winters Mark , Hopmans Erik S. , Bell John M. , Grimes Susan M. , Xia Li C. , Zhang Nancy R. , Moss Ronald B. , Holodniy Mark , Ji Hanlee P. 
Published: November 2015

AbstractInfluenza remains a significant cause of disease mortality. The ongoing threat of influenza infection is partly attributable to the emergence of new mutations in the influenza genome. Among the influenza viral gene products, the hemagglutinin (HA) glycoprotein plays a critical role in influenza pathogenesis, is the target for vaccines and accumulates new mutations that may alter the efficacy of immunization. To study the emergence of HA mutations during the course of infection, we employed a deep-targeted sequencing method. We used samples from 17 patients with active H1N1 or H3N2 influenza infections. These patients were not treated with antivirals. In addition, we had samples from five patients who were analyzed longitudinally. Thus, we determined the quantitative changes in the fractional representation of HA mutations during the course of infection. Across individuals in the study, a series of novel HA mutations directly altered the HA coding sequence were identified. Serial viral sampling revealed HA mutations that either were stable, expanded or were reduced in representation during the course of the infection. Overall, we demonstrated the emergence of unique mutations specific to an infected individual and temporal genetic variation during infection.
Surface and Bulk Carbide Transformations in High-Speed Steel
Authors: Godec M. , Večko Pirtovšek T. , Šetina Batič B. , McGuiness P. , Burja J. , Podgornik B. 
Published: November 2015

AbstractWe have studied the transformation of carbides in AISI M42 high-speed steels in the temperature window used for forging. The annealing was found to result in the partial transformation of the large, metastable M2C carbides into small, more stable grains of M6C, with an associated change in the crystal orientation. In addition, MC carbides form during the transformation of M2C to M6C. From the high-speed-steel production point of view, it is beneficial to have large, metastable carbides in the cast structure, which later during annealing, before the forging, transform into a structure of polycrystalline carbides. Such carbides can be easily decomposed into several small carbides, which are then randomly distributed in the microstructure. The results also show an interesting difference in the carbide-transformation reactions on the surface versus the bulk of the alloy, which has implications for in-situ studies of bulk phenomena that are based on surface observations.
IDH mutation status is associated with a distinct hypoxia/angiogenesis transcriptome signature which is non-invasively predictable with rCBV imaging in human glioma
Authors: Kickingereder Philipp , Sahm Felix , Radbruch Alexander , Wick Wolfgang , Heiland Sabine , Deimling Andreas von , Bendszus Martin , Wiestler Benedikt 
Published: November 2015

AbstractThe recent identification of IDH mutations in gliomas and several other cancers suggests that this pathway is involved in oncogenesis; however effector functions are complex and yet incompletely understood. To study the regulatory effects of IDH on hypoxia-inducible-factor 1-alpha (HIF1A), a driving force in hypoxia-initiated angiogenesis, we analyzed mRNA expression profiles of 288 glioma patients and show decreased expression of HIF1A targets on a single-gene and pathway level, strong inhibition of upstream regulators such as HIF1A and downstream biological functions such as angio- and vasculogenesis in IDH mutant tumors. Genotype/imaging phenotype correlation analysis with relative cerebral blood volume (rCBV) MRI – a robust and non-invasive estimate of tumor angiogenesis – in 73 treatment-naive patients with low-grade and anaplastic gliomas showed that a one-unit increase in rCBV corresponded to a two-third decrease in the odds for an IDH mutation and correctly predicted IDH mutation status in 88% of patients. Together, these findings (1) show that IDH mutation status is associated with a distinct angiogenesis transcriptome signature which is non-invasively predictable with rCBV imaging and (2) highlight the potential future of radiogenomics (i.e. the correlation between cancer imaging and genomic features) towards a more accurate diagnostic workup of brain tumors.
Genetic evidence of a recent Tibetan ancestry to Sherpas in the Himalayan region
Authors: Bhandari Sushil , Zhang Xiaoming , Cui Chaoying , Bianba  , Liao Shiyu , Peng Yi , Zhang Hui , Xiang Kun , Shi Hong , Ouzhuluobu  , Baimakongzhuo  , Gonggalanzi  , Liu Shimin , Gengdeng  , Wu Tianyi , Qi Xuebin , Su Bing 
Published: November 2015

AbstractSherpas living around the Himalayas are renowned as high-altitude mountain climbers but when and where the Sherpa people originated from remains contentious. In this study, we collected DNA samples from 582 Sherpas living in Nepal and Tibet Autonomous Region of China to study the genetic diversity of both their maternal (mitochondrial DNA) and paternal (Y chromosome) lineages. Analysis showed that Sherpas share most of their paternal and maternal lineages with indigenous Tibetans, representing a recently derived sub-lineage. The estimated ages of two Sherpa-specific mtDNA sub-haplogroups (C4a3b1 and A15c1) indicate a shallow genetic divergence between Sherpas and Tibetans less than 1,500 years ago. These findings reject the previous theory that Sherpa and Han Chinese served as dual ancestral populations of Tibetans and conversely suggest that Tibetans are the ancestral populations of the Sherpas, whose adaptive traits for high altitude were recently inherited from their ancestors in Tibet.
Slc15a1 is involved in the transport of synthetic F5-peptide into the seminiferous epithelium in adult rat testes
Authors: Su Linlin , Zhang Yufei , Cheng Yan C. , Lee Will M. , Ye Keping , Hu Dahai 
Published: November 2015

AbstractSpermiation and BTB restructuring, two critical cellular events that occur across seminiferous epithelium in mammalian testis during spermatogenesis, are tightly coordinated by biologically active peptides released from laminin chains. Our earlier study reported that F5-peptide, synthesized based on a stretch of 50 amino acids within laminin-γ3 domain IV, could reversibly induce the impairment of spermatogenesis, disruption of BTB integrity and germ cell loss and thus is a promising male contraceptive. However, how F5-peptide when administered intratesticularly enters seminiferous tubules and exerts effects beyond BTB is currently unknown. Here we demonstrated that Slc15a1, a peptide transporter also known as Pept1, was predominantly present in peritubular myoid cells, interstitial Leydig cells, vascular endothelial cells and germ cells, while absent in Sertoli cells or BTB site. The steady-state protein level of Slc15a1 in adult rat testis was not affected by F5-peptide treatment. Knockdown of Slc15a1 byin vivoRNAi in rat testis was shown to prevent F5-peptide induced disruptive effects on spermatogenesis. This study suggests that Slc15a1 is involved in the transport of synthetic F5-peptide into seminiferous epithelium and thus Slc15a1 is a novel target in testis that could be genetically modified to improve the bioavailability of F5-peptide as a prospective male contraceptive.
Screening and validation for plasma biomarkers of nephrotoxicity based on metabolomics in male rats
Authors: Li Yubo , Deng Haoyue , Ju Liang , Zhang Xiuxiu , Zhang Zhenzhu , Yang Zhen , Wang Lei , Hou Zhiguo , Zhang Yanjun 
Published: November 2015

Abstract
Currently, drug-induced nephrotoxicity is widespread and seriously affects human health. However, the conventional indexes of renal function lack sensitivity, leading to a delay in the detection of nephrotoxicity. Therefore, we need to identify more sensitive indexes for evaluating nephrotoxicity. In this study, we used gentamicin (100 mg kg−1), etimicin (100 mg kg−1) and amphotericin B (4 mg kg−1) to establish renal injury models in rats, and we collected information using ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry in the screening stage. Thirteen nephrotoxicity metabolites were selected after multivariate statistical and integration analyses. Then, we conducted trend analysis to select 5 nephrotoxicity biomarkers [thymidine, LysoPC(16:1), LysoPC(18:4), LysoPC(20:5), and LysoPC(22:5)] whose content changed consistently at different timepoints after drug administration. To verify the sensitivity and specificity of these biomarkers for nephrotoxicity, receiver operating characteristic (ROC) and support vector machine (SVM) analyses were applied. The area under the curve of the 5 biomarkers were 0.806–0.901 at the 95% confidence interval according to the ROC analysis. We used the SVM classified model to verify these biomarkers, and the prediction rate was 95.83%. Therefore, the 5 biomarkers have strong sensitivity and high accuracy; these biomarkers are more sensitive indexes for evaluating renal function to identify nephrotoxicity and initiate prompt treatment.
Toxicity mechanism in fetal lung fibroblast cells for multi-walled carbon nanotubes defined by chemical impurities and dispersibility
Authors: Shinde Aparna , Tsai Candace S. J. 
Published: November 2015

Abstract
Multi-walled carbon nanotubes (MWCNTs) are beneficial in a wide range of applications in fields such as electronics, optics and nano-medicine, so knowledge concerning their effect on human health is important. Physiochemical properties of MWCNTs can greatly affect their toxicity, however, there are no reports discussing the effect of size and chemical composition of MWCNTs on the toxic response of human lung cells. In this study, MWCNTs of two different purity grades were characterized and their toxic effects were compared on normal fetal lung fibroblast MRC-5 cells. The toxic effect on MRC-5 cells following 1–3 days exposure to low concentrations of research grade (RG) and industrial grade (IG) MWCNTs were studied using multiple biological assays. MWCNTs uptake in MRC-5 cells was analyzed using TEM. After physical and chemical analysis, RG-MWCNTs revealed contamination with MoS2 and were readily suspended in distilled water while IG-MWCNTs had no MoS2 contamination and much lower dispersibility. For a wide range of concentrations and exposure times, cells treated with RG-MWCNTs had distinctly reduced cell viability as compared to cells treated with IG-MWCNTs. Treatment with RG-MWCNTs resulted in high reactive oxygen/nitrogen species (ROS/RNS) levels indicating an oxidative stress mechanism while IG-MWCNT treated cells had low ROS/RNS amounts and a distorted cell membrane pointing towards a non-oxidative stress mechanism. Both agglomerates and individual MWCNTs were internalized efficiently by MRC-5 cells, which resulted in cell damage and ultimately cell death. Altogether, this study shows that the MoS2 contamination and size of MWCNTs’ agglomerates affect the mechanism of toxicity in human fetal lung fibroblasts.
GeoSRM – Online geospatial safety risk model for the GB rail network
Authors: Sadler Jason , Griffin David , Gilchrist Alex , Austin Jeremy , Kit Oles , Heavisides Jay 
Published: November 2015

RSSB and the University of Southampton's GeoData Institute have collaborated to research and develop a toolkit for managing large volumes of rail risk data. The pilot system encompasses concepts of highly complex geospatial ‘big data’, open standards, open source development tools and methodologies, and enables stakeholders to filter, analyse and visualise risk across the rail network, for a range of risk models. These include train derailments, suicides and passenger slip, trips and falls, and feature a wide range of spatially dependent parameters that affect the causal, escalation and consequence mechanisms. The risk has been calculated to a high resolution, splitting 2,100,000 m of track typically into 10 m sections. By creating geospatial representations of risk, the tool can help to identify risk hotspots and in this way contribute to the improvement of rail safety. Once scaled up to a National level and full range of risk models, the tool will deliver a powerful capability, unique across Europe. Further research is extending the prototype to incorporate live and historic environmental and related rail incident data to augment and improve the risk model.
Ordering a Disordered World through Language: Metapragmatic Dissonance and the “Misreading” of an Indexical Relationship
Authors: Moskowitz Nona 
Published: November 2015

AbstractMainland Japanese middle-school teachers working on Chichijima Island encounter an address pattern they describe as unusual. While students address teachers using last name and honorific title, teachers call students by their first names only. Some of the teachers experience the indexical relationship between the exchanged forms as a nonreciprocal disjuncture, describing it as “too hierarchical;” others experience it as a reciprocal disjuncture, saying it creates a “too close” atmosphere in the school. Many who do not fall back on the culture-internal stereotype are teachers who struggle to maintain authority in the classroom. Here, these teachers’ “misreading” of the indexical meanings associated with the address forms invokes a trope of misunderstanding where a theoretical repair is summoned as a means to fix a problem. Silverstein’s model of indexical orders provides a means to understand the metapragmatic dissonance that characterizes teachers’ discourse.
Quenching star formation: insights from the local main sequence
Authors: Leslie S. K. , Kewley L. J. , Sanders D. B. , Lee N. 
Published: November 2015

Abstract
The so-called star-forming main sequence of galaxies is the apparent tight relationship between the star formation rate and stellar mass of a galaxy. Many studies exclude galaxies which are not strictly ‘star forming’ from the main sequence, because they do not lie on the same tight relation. Using local galaxies in the Sloan Digital Sky Survey, we have classified galaxies according to their emission line ratios, and studied their location on the star formation rate–stellar mass plane. We find that galaxies form a sequence from the ‘blue cloud’ galaxies which are actively forming stars, through a combination of composite, Seyfert, and low-ionization nuclear emission-line region galaxies, ending as ‘red-and-dead’ galaxies. The sequence supports an evolutionary pathway for galaxies in which star formation quenching by active galactic nuclei plays a key role.
Adult patients with supratentorial pilocytic astrocytoma: long-term follow-up of prospective multicenter clinical trial NCCTG-867251 (Alliance)
Authors: Brown Paul D. , Anderson S. Keith , Carrero Xiomara W. , O'Neill Brian P. , Giannini Caterina , Galanis Eva , Shah Sunjay A. , Abrams Ross A. , Curran Walter J. , Buckner Jan C. , Shaw Edward G. 
Published: November 2015

Abstract

Background
Pilocytic astrocytoma is a rare tumor in adults. This report is of a prospective clinical trial with long-term follow-up.

Methods
Between 1986 and 1994, 20 eligible adults with supratentorial pilocytic astrocytomas were enrolled in a prospective intergroup trial of radiotherapy (RT) after biopsy (3 patients) or observation after gross (11 patients) or subtotal (6 patients) resection.

Results
At the time of analysis (median follow-up, 20.8 years), 2 patients (10%) have died and 18 patients (90%) are alive. Neurologic and cognitive function were stable or improved over time for the majority of patients. No toxic effects of treatment or malignant transformations have been recorded at last follow-up. For the entire cohort the 20-year time to progression and overall survival rates are 95% and 90% respectively. The cause of death (2.2 and 16.1 years after enrollment) in both patients was unrelated to tumor although both were biopsy-only patients. One subtotally resected tumor progressed 1 month after enrollment requiring P32 injection into an enlarging cyst. Because of further progression this patient required RT 18 months later. This patient is alive without evidence of progression 18 years after RT.

Conclusion
The long-term follow-up results of this prospective trial confirm that adults with pilocytic astrocytomas have a favorable prognosis with regard to survival and neurologic function. Close observation is recommended for adults with pilocytic astrocytomas, reserving RT for salvage, as the majority remain stable after gross or subtotal resection and no adjuvant therapy.
Two ' s company, but three ' s no crowd
Authors: Shah Chirag , Hendahewa Chathra , González-Ibáñez Roberto 
Published: November 2015

Purpose– The purpose of this paper is to investigate when and how people working in collaboration could be benefitted by an exploratory search task, specifically focussing on team size and its effect on the outcomes of such a task.Design/methodology/approach– The paper investigates the effects of team sizes on exploratory search tasks using a lab study involving 68 participants – 12 individuals, ten dyads, and 12 triads. In order to assess various factors during their exploratory search sessions, an evaluation framework is synthesized using relevant literature. The framework consists of measures for five groups of quantities relevant to exploratory search: information exposure, information relevancy, information search, performance, and learning.Findings– The analyses on the user study data using the proposed framework reveals that while individuals working alone cover more information than those working in teams, the teams (dyads and triads) are able to achieve better information coverage and search performance due to their collaborative strategies. In many of the measures, the triads are found to be even better than the dyads, demonstrating the value of adding a collaborator to a search process with multiple facets.Originality/value– The findings shed light on not only how collaborative work could help in achieving better results in exploratory search, but also how team sizes affect specific aspects – information exposure, information relevancy, information search, performance, and learning – of exploratory search. This has implications for system designers, information managers, and educators.
A decade of evolving composites: regression- and meta-analysis
Authors: Frowd Charlie D. , Erickson William B. , Lampinen James M. , Skelton Faye C. , McIntyre Alex H. , Hancock Peter J.B. 
Published: November 2015

Purpose– The purpose of this paper is to assess the impact of seven variables that emerge from forensic research on facial-composite construction and naming using contemporary police systems: EvoFIT, Feature and Sketch.Design/methodology/approach– The paper involves regression- and meta-analyses on composite-naming data from 23 studies that have followed procedures used by police practitioners for forensic face construction. The corpus for analyses contains 6,464 individual naming responses from 1,069 participants in 41 experimental conditions.Findings– The analyses reveal that composites constructed from the holistic EvoFIT system were over four-times more identifiable than composites from “Feature” (E-FIT and PRO-fit) and Sketch systems; Sketch was somewhat more effective than Feature systems. EvoFIT was more effective when internal features were created before rather than after selecting hair and the other (blurred) external features. Adding questions about the global appearance of the face (as part of the holistic-cognitive interview (H-CI)) gives a valuable improvement in naming over the standard face-recall cognitive interview (CI) for all three system types tested. The analysis also confirmed that composites were considerably less effective when constructed from a long (one to two days) compared with a short (0-3.5 hours) retention interval.Practical implications– Variables were assessed that are of importance to forensic practitioners who construct composites with witnesses and victims of crime.Originality/value– Using a large corpus of forensically-relevant data, the main result is that EvoFIT using the internal-features method of construction is superior; an H-CI administered prior to face construction is also advantageous (cf. face-recall CI) for EvoFIT as well as for two further contrasting production systems.