bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fine-tuned echolocation and capture-flight ofMyotis capacciniiwhen facing different sized insects and fish prey
Authors: Aizpurua Ostaizka , Aihartza Joxerra , Alberdi Antton , Baaøge Hans J. , Garin Inazio 
Published: July 2014

AbstractFormerly thought to be a strictly insectivorous trawling bat, recent studies have shown that Myotis capaccinii also preys on fish. To determine if differences exist in bat flight behaviour, prey handling, and echolocation characteristics when catching fish and insects of different sizes, we conducted a field experiment focused on the last stage of prey capture. We used synchronized video and ultrasound recordings to measure several flight and dip features as well as echolocation characteristics, focusing on terminal buzz phase I, characterized by a call rate exceeding 100 Hz, and buzz phase II, characterized by a drop in the fundamental well below 20 kHz and a repetition rate exceeding 150 Hz. When capturing insects, bats used both parts of the terminal phase to the same extent, and performed short and superficial drags on the water surface. In contrast, when preying on fish, buzz I was longer and buzz II shorter, and the bats made longer and deeper dips. These variations suggest that lengthening buzz I and shortening buzz II when fishing is beneficial, probably because buzz I gives better discrimination ability and the broader sonar beam provided by buzz II is useless when no evasive flight of the prey is expected. Additionally, bats continued emitting calls beyond the theoretical signal-overlap zone, suggesting that they might obtain information even when they have surpassed that threshold, at least initially. This study shows that M. capaccinii can regulate the temporal components of its feeding buzzes and modify prey capture technique according to the target.
A combination of gyroscope and accelerometer for identifying alternative feeding behaviours in fish
Authors: Kawabata Yuuki , Noda Takuji , Nakashima Yuuki , Nanami Atsushi , Sato Taku , Takebe Takayuki , Mitamura Hiromichi , Arai Nobuaki , Yamaguchi Tomofumi , Soyano Kiyoshi 
Published: July 2014

AbstractWe examined whether we could identify the feeding behaviours of the trophic generalist fish Epinephelus ongus on different prey types (crabs and fish) using a data-logger that incorporated a 3-axis gyroscope and a 3-axis accelerometer. Feeding behaviours and other burst behaviours, including escape responses, intraspecific interactions, and routine movements, were recorded from six E. ongus individuals using data-loggers sampling at 200 Hz, and were validated by simultaneously recorded video images. For each data-logger record, we extracted 5 seconds of data when any of the 3-axis accelerations exceeded absolute 2.0 G, to capture all feeding behaviours and other burst behaviours. Each feeding behaviour was then identified using a combination of parameters that were derived from the extracted data. Using decision trees with the parameters, high true identification rates (87.5% for both feeding behaviours) with low false identification rates (5% for crab-eating and 6.3% for fish-eating) were achieved for both feeding behaviours.
Non-human lnc-DC orthologs encode Wdnm1-like protein
Authors: Dijkstra Johannes M. , Ballingall Keith T. 
Published: July 2014

In a recent publication in Science, Wang et al. found a long noncoding RNA (lncRNA) expressed in human dendritic cells (DC), which they designated lnc-DC. Based on lentivirus-mediated RNA interference (RNAi) experiments in human and murine systems, they concluded that lnc-DC is important in differentiation of monocytes into DC. However, Wang et al. did not mention that their so-called “mouse lnc-DC ortholog” gene was already designated “Wdnm1-like” and is known to encode a small secreted protein. We found that incapacitation of the Wdnm1-like open reading frame (ORF) is very rare among mammals, with all investigated primates except for hominids having an intact ORF. The null-hypothesis by Wang et al. therefore should have been that the human lnc-DC transcript might only represent a non-functional relatively young evolutionary remnant of a protein coding locus. Whether this null-hypothesis can be rejected by the experimental data presented by Wang et al. depends in part on the possible off-target (immunogenic or otherwise) effects of their RNAi procedures, which were not exhaustive in regard to the number of analyzed RNAi sequences and control sequences. If, however, the conclusions by Wang et al. on their human model are correct, and they may be, current knowledge regarding the Wdnm1-like locus suggests an intriguing combination of different functions mediated by transcript and protein in the maturation of several cell types at some point in evolution. We feel that the article by Wang et al. tends to be misleading without the discussion presented here.
Accelerating Regulatory Progress in Multi-Institutional Research
Authors: Paolino Andrea R. , Lauf Sherry L. , Pieper Lisa E. , Rowe Jared , Vargas Ileana M. , Goff Melissa A. , Daley Matthew F. , Tuzzio Leah , Steiner John F. 
Published: July 2014

Purpose: Multi-institutional collaborations are necessary in order to create large
and robust data sets that are needed to answer important comparative effectiveness
research (CER) questions. Before scientific work can begin, a complex maze of
administrative and regulatory requirements must be efficiently navigated to avoid
project delays.Innovation: Staff from research, regulatory, and administrative teams
involved in three HMO Research Network (HMORN) multi-institutional collaborations
developed and employed novel approaches: to secure and maintain Institutional Review
Board (IRB) approvals; to enable data sharing, and to expedite subawards for two
data-only minimal risk studies. These novel approaches accelerated required processes
and approvals while maintaining regulatory, human subjects, and institutional
protections.Credibility: Outcomes from the processes described here are compared with
processes outlined in the research and regulatory literature and with processes that
have been used in previous multisite research collaborations.Conclusion and
Discussion: Research, regulatory, and administrative staff are essential contributors to
the success of multi-institutional collaborations. Their flexibility, creativity, and
effective communication skills can lead to the development of efficient approaches to
achieving the necessary oversight for these complex projects. Elements of these specific
strategies can be adapted and used by other research networks. Other efforts in these
areas should be evaluated and shared. The processes that help develop a “learning
research system” play an important and complementary role in sustaining
multi-institutional research collaborations.
Cutaneous Intravascular Natural Killer–Cell Lymphoma
Authors: Liu Yanli , Zhang Wen , An Jie , Li Hui , Liu Shuang 
Published: July 2014

Abstract

Objectives:
To our knowledge, since 2003, there have been 11 reported cases of intravascular natural killer (NK)–cell lymphoma (IVNKL). Herein we describe the 12th case.

Methods:
H&E and Envision immunohistochemical stains as well as in situ hybridization were used to study this disease in combination with review of the literature.

Results:
Half of the cases reported to date are from China and Taipei. The clinical manifestation of IVNKL is erythema in the limbs and trunk, although patients’ conditions have varied notably from each other. One-year survival rate is about 40%.

Conclusions:
IVNKL should be distinguished from extranodal NK/T-cell lymphoma (nasal type) and aggressive NK-cell leukemia. These three diseases have a similar phenotype and are all related to Epstein-Barr virus infection. However, the pathogenesis of similarities and differences needs further study. In particular, IVNKL is quite unusual. The treatment of IVNKL is difficult, and the prognosis is poor. Currently, IVNKL is not included in the World Health Organization classification subtypes and has been classified into NK/T-cell lymphoma (nasal type). However, in view of the unique characteristics of this disease, we propose that the diagnosis be independent, since this will facilitate further study of this disease.
Severity of Rhinovirus Infection in Hospitalized Adults Is Unrelated to Genotype
Authors: McCulloch Denise J. , Sears Marti H. , Jacob Jesse T. , Lyon G. Marshall , Burd Eileen M. , Caliendo Angela M. , Hill Charles E. , Nix W. Allan , Oberste M. Steven , Kraft Colleen S. 
Published: July 2014

AbstractObjectivesTo determine whether rhinovirus (RV) species is associated with more severe clinical illness in adults.MethodsSeventy-two RV-positive viral respiratory samples from adult patients were sequenced and analyzed phylogenetically after reverse transcriptase polymerase chain reaction of the region spanning the VP4 gene and 5′ terminus of the VP2 gene. The clinical features and severity of illness associated with the different RV species were compared.ResultsPhylogenetic analysis identified three distinct clusters as RV-A (54%), B (11%), or C (35%) species. In an unadjusted model, patients with RV-B infection were significantly more likely to have the composite outcome variable of death or intensive care unit admission (P = .03), but this effect diminished when controlling for patient sex. A logistic model of the relationship between RV species and adverse outcomes produced nonsignificant odds ratios when controlling for patient sex.ConclusionsInfection with RV-A or RV-B was associated with greater severity of illness in our adult population; however, the association disappeared after controlling for confounders.
Well-Differentiated Papillary Mesothelioma of the Peritoneum
Authors: Nasit Jitendra G. , Dhruva Gauravi 
Published: July 2014

Abstract

Objectives:
Well-differentiated papillary mesothelioma of the peritoneum (WDPMP) is an uncommon subtype of epithelioid mesothelioma. Usually, WDPMP has a benign course, while a few patients have multiple recurrence and malignant transformation on long-term follow-up. The histology of WDPMP has been well studied compared with the cytology. Although accurate diagnosis is based only on histology and immunohistochemical stains, knowledge of the cytologic features of WDPMP in context with clinical and radiologic features is essential to predict a preoperative diagnosis and guide proper management, after excluding reactive mesothelial hyperplasia, malignant mesothelioma, and serous neoplasms of the ovaries and peritoneum. Surgical excision gives a favorable outcome.

Methods:
We describe a case of 28-year-old woman who sought treatment for chronic lower abdominal pain, dysuria, and dyspareunia.

Results:
Radiologic findings suggested multiple metastatic peritoneal deposits. Ultrasound-guided fine-needle aspiration cytology showed many papillae, tubulopapillary and spheroid groups, monolayered pavement-like sheets, and many dispersed cells. Papillae showed many layers of round to ovoid cells, with minimal atypia. Atypical mitoses and necrosis were not found. A cytologic diagnosis of WDPMP was suggested. After complete resection of all the tumor nodules, histopathology and immunohistochemical findings were compatible with WDPMP. On follow-up, she developed tumor recurrence at 9 months and was managed successfully with adjuvant chemotherapy.

Conclusions:
This article highlights the cytologic features of WDPMP with relevant review of the literature and differential diagnosis.
ERCC1-Positive Circulating Tumor Cells in the Blood of Ovarian Cancer Patients as a Predictive Biomarker for Platinum Resistance
Authors: Kuhlmann Jan Dominik , Wimberger Pauline , Bankfalvi Agnes , Keller Thomas , Schöler Sarah , Aktas Bahriye , Buderath Paul , Hauch Siegfried , Otterbach Friedrich , Kimmig Rainer , Kasimir-Bauer Sabine 
Published: July 2014

Abstract

BACKGROUND
Platinum resistance constitutes one of the most recognized clinical challenges for ovarian cancer. Notably, the detection of the primary tumor-based excision repair cross-complementation group 1 (ERCC1) protein by immunohistochemistry was recently shown to be inaccurate for the prediction of platinum resistance. On the basis of the previous finding that circulating tumor cells (CTC) in the blood of ovarian cancer patients are prognostically significant, and given our hypothesis that the negative prognostic impact of CTC may arise from a cellular phenotype associated with platinum resistance, we asked whether expression of the excision repair cross-complementation group 1 (ERCC1) gene in the form of the ERCC1 transcript in CTC may be a suitable blood-based biomarker for platinum resistance.

METHODS
The presence of CTC was analyzed by immunomagnetic CTC enrichment (n = 143 patients) targeting the epithelial epitopes epithelial cell adhesion molecule (EPCAM) (also known as GA733-2) and mucin 1, cell surface associated (MUC1), followed by multiplex reverse-transcription PCR to detect the transcripts EPCAM, MUC1, and mucin 16, cell surface associated (MUC16) (also known as CA125), including ERCC1 transcripts in a separate approach. ERCC1 expression in primary tumors was comparatively assessed by immunohistochemistry, using the antibody 8F1.

RESULTS
At primary diagnosis, the presence of CTC was observed in 14% of patients and constituted an independent predictor of overall survival (OS) (P = 0.041). ERCC1-positive CTC (ERCC1+CTC) were observed in 8% of patients and constituted an independent predictor, not only for OS but also for progression-free survival (PFS) (P = 0.026 and P = 0.009, respectively). More interestingly, we discovered the presence of ERCC1+CTC at primary diagnosis to be likewise an independent predictor of platinum resistance (P = 0.010), whereas ERCC1 expression in corresponding primary tumor tissue predicted neither platinum resistance nor prognosis.

CONCLUSIONS
The presence of ERCC1+CTC can serve as a blood-based diagnostic biomarker for predicting platinum resistance at primary diagnosis of ovarian cancer.
Validation of the names of two new species of Codium (Chlorophyta, Bryopsidales) from Isla Guadalupe and Rocas Alijos, Pacific Mexico and the southern California Channel Islands, with some remarks on insular endemism
Authors: Silva Paul C. , Pedroche Francisco F. , Chacana Max E. , Miller Kathy Ann 
Published: July 2014

Abstract
The names Codium schmiederi and Codium dawsonii are validated by the provision of designated types. The species to which the invalidly published name C. schmiederi applies is known only from Isla Guadalupe and Rocas Alijos, Baja California, Mexico. The history of phycological exploration of these two remote localities is detailed. The species to which the invalidly published name C. dawsonii applies is found in those two localities as well as on coastal islands of Baja California and southern California. It is seldom found on the mainland. Codium hubbsii, originally described from Islas San Benito, has a distribution similar to that of C. dawsonii, but occurs more often on the mainland. The distributions of these three species constitute a pattern of insular endemism.
Modeling of a Bridge-Shaped Nonlinear Piezoelectric Energy Harvester
Authors: Gafforelli Giacomo , Xu Ruize , Corigliano Alberto , Kim Sang-Gook 
Published: July 2014

AbstractPiezoelectric microelectromechanical systems (MEMS) energy harvesting is an attractive technology for harvesting small energy from ambient vibrations. Increasing the operating frequency bandwidth of such devices is one of the major challenges to be solved for real-world applications. A MEMS-scale doubly clamped nonlinear beam resonator has demonstrated very wide bandwidth and high-power density among the energy harvesters reported. In this paper, a first complete theoretical discussion of nonlinear resonance-based piezoelectric energy harvesting is provided. The sectional behavior of the beam has been studied through the Classical Lamination Theory (CLT) specifically modified to introduce the piezoelectric coupling and nonlinear Green-Lagrange strain tensor. A lumped parameter model has been built through Rayleigh–Ritz method and the resulting nonlinear coupled equations have been solved in the frequency domain through the Harmonic Balance Method (HBM). Finally, the influence of external load resistance on the dynamic behavior has been studied. The theoretical model shows that nonlinear resonant harvesters have much wider power bandwidth than that of linear resonators but their maximum power is still bounded by the mechanical damping as is the case for linear resonating harvesters.
Sulfonated fluorinated-aromatic polymers as proton exchange membranes
Authors: Ghosh Anindita , Banerjee Susanta 
Published: July 2014

AbstractIn recent years, extensive research on the preparation and properties of proton exchange membranes (PEMs) has been realized. This article focusses on the recent studies on new PEM materials based on aromatic hydrocarbon polymers with sulfonated groups as hydrophilic domains and fluorinated groups as hydrophobic domains as alternatives to conventional perfluorinated polymers. It is necessary to improve the proton conductivity especially under low-humidity conditions and at high operating temperatures to break through the current aromatic PEM system. Hence, there is a need to develop new high-conductivity fuel cell ionomers with improved thermal, chemical, and electrochemical stability by designing a suitable polymer structure for PEM application.
Modelling and Analysis of a Three-Phase to Five-Phase Transformer
Authors: Khan M. Rizwan , Alammari Rashid , Moinoddin Shaikh , Iqbal Atif 
Published: July 2014

Abstract
Multi-phase systems are the focus of research in recent times due to their inherent advantages compared to the three-phase counterpart. A lot of research effort has been put to develop commercially feasible multi-phase drive systems. There is a necessity to develop a static phase transformation system to obtain multi-phase supply from available three-phase grid. This paper presents an extension of a novel transformer connection scheme to convert three-phase supply to five-phase fixed voltage and fixed frequency supply already published. The various simulation and experimental results are reported in this paper to prove the viability of system.
Randomization Inference in the Regression Discontinuity Design: An Application to Party Advantages in the U.S. Senate
Authors: Cattaneo Matias D. , Frandsen Brigham R. , Titiunik Rocío 
Published: July 2014

AbstractIn the Regression Discontinuity (RD) design, units are assigned a treatment based on whether their value of an observed covariate is above or below a fixed cutoff. Under the assumption that the distribution of potential confounders changes continuously around the cutoff, the discontinuous jump in the probability of treatment assignment can be used to identify the treatment effect. Although a recent strand of the RD literature advocates interpreting this design as a local randomized experiment, the standard approach to estimation and inference is based solely on continuity assumptions that do not justify this interpretation. In this article, we provide precise conditions in a randomization inference context under which this interpretation is directly justified and develop exact finite-sample inference procedures based on them. Our randomization inference framework is motivated by the observation that only a few observations might be available close enough to the threshold where local randomization is plausible, and hence standard large-sample procedures may be suspect. Our proposed methodology is intended as a complement and a robustness check to standard RD inference approaches. We illustrate our framework with a study of two measures of party-level advantage in U.S. Senate elections, where the number of close races is small and our framework is well suited for the empirical analysis.
Antenatal testing in uncomplicated pregnancies: should testing be initiated after 40 or 41 weeks?
Authors: Mackeen A. Dhanya , Edelson P. Kaitlyn , Wisch Susan , Plante Lauren , Weiner Stuart 
Published: July 2014

Abstract

Objective: This study aims to compare outcomes of antenatal testing in women who received testing between 40 weeks and 40+6 weeks versus those who received testing at ≥41 weeks.

Materials and methods: This retrospective study included women without maternal comorbidities, who were referred for outpatient antenatal testing for gestational age ≥40 weeks. We compared women who received antenatal testing between 40 and 40+6 weeks (Group 1), to those who were only tested at ≥41 weeks (Group 2).

Results: A total of 827 Group 1 and 244 Group 2 pregnancies were evaluated. One-hundred and eighty-nine (18%) were sent to labor and delivery (L&D) for further evaluation. There were no significant differences between groups in terms of being sent or admitted to labor and delivery, the reason for which women were sent, induction of labor, mode of delivery, neonatal length of stay, or admission to intensive care.

Conclusion: Pregnancies tested at 40 weeks were identified as abnormal and sent to L&D at the same rate as those tested at 41 weeks. Therefore, it may be reasonable to initiate fetal surveillance at the estimated date of delivery.
Placental gene expression of inflammatory markers and growth factors – a case control study of obese and normal weight women
Authors: Allbrand Marianne , Bjorkqvist Maria , Nilsson Kerstin , Ostlund Ingrid , Aman Jan 
Published: July 2014

Abstract

Objective: To survey the placental gene expression of inflammatory markers and growth factors in non-smoking obese women with an uncomplicated pregnancy without associated morbidity and delivery at term compared with normal weight women.

Methods: Placental tissue samples from 32 obese women (body mass index, BMI≥35.0 kg/m2) were compared with samples from 94 normal weight women (BMI 18.5–25.0 kg/m2) matched for age (±1 year), gestational age (±3 days), parity and mode of delivery. Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) was used to analyse toll receptor-2 and -4, interleukin-6 and -8, tumour necrosis factor-α, leptin, adiponectin, insulin-like growth factor-1 and -2, hepatocyte growth factor, hepatocyte growth factor receptor and insulin receptor.

Results: There was no significant difference in gene expression in placental tissue samples from obese and normal weight women.

Conclusion: We found no difference in the occurrence of inflammatory marker and growth factor mRNA levels in placental tissue samples from a large group of obese women without associated morbidity and with healthy infants compared to a closely matched control group of healthy normal weight women. Compared with the previous studies, this anomalous finding may be explained by the absence of associated morbidity in the obese women in our study.
The value of lipopolysaccharide binding protein for diagnosis of late-onset neonatal sepsis in very low birth weight infants
Authors: Leante-Castellanos José Luis , de Guadiana-Romualdo Luis García , Fuentes-Gutiérrez Carmen , Hernando-Holgado Ana , García-González Ana , Jiménez-Santos Enrique 
Published: July 2014

Abstract

Objective: To assess the accuracy of lipopolysaccharide binding protein (LBP) for diagnosing late-onset neonatal sepsis (LONS) in very low birth weight (VLBW) infants.

Study design: Observational, prospective study. We assessed the diagnostic performance of LBP in 26 suspected LONS episodes among 54 patients. Proven and probable LONS episodes were recorded according to established criteria. Receiver operating characteristic curve analysis was performed to evaluate LBP’s ability to predict LONS.

Results: LONS was diagnosed in 17 of 26 episodes. LBP levels were significantly higher in confirmed LONS episodes (P<0.001). The area under the curve of LBP was 0.89. A cut-off of 17.5 μg/mL had a sensitivity of 94.1%, a specificity of 77.8%, a positive predictive value of 88.9% and a negative predictive value of 87.5%.

Conclusions: Serum LBP measurement may be useful as an additional tool in the evaluation of suspected LONS in VLBW infants.