bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetic Retinopathy, Its Progression, and Incident Cardiovascular Events in the ACCORD Trial
Authors: Gerstein Hertzel C. , Ambrosius Walter T. , Danis Ronald , Ismail-Beigi Faramarz , Cushman William , Calles Jorge , Banerji MaryAnn , Schubart Ulrich , Chew Emily Y. ,   for the ACCORD Study Group
Published: December 2012

OBJECTIVE
Both the presence of diabetic retinopathy and its severity are significantly associated with future cardiovascular (CV) events. Whether its progression is also linked to incident CV outcomes hasn’t been assessed.

RESEARCH DESIGN AND METHODS
The relationship between retinopathy, its 4-year progression, and CV outcomes (CV death or nonfatal myocardial infarction or stroke) was analyzed in participants in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial who also participated in the ACCORD Eye Study. Retinopathy was classified as either none, mild, moderate, or severe, and worsening was classified as a &lt;2-step, 2–3-step, or &gt;3-step change (that included incident laser therapy or vitrectomy).

RESULTS
Participants (n = 3,433) of mean age 61 years had baseline retinal photographs (seven stereoscopic fields). Compared with no retinopathy, the adjusted HRs (95% CI) for the CV outcome rose from 1.49 (1.12–1.97) for mild retinopathy to 2.35 (1.47–3.76) for severe retinopathy. A subset of 2,856 was evaluated for progression of diabetic retinopathy at 4 years. The hazard of the primary outcome increased by 38% (1.38 [1.10–1.74]) for every category of change in retinopathy severity. Additional adjustment for the baseline and follow-up levels of A1C, systolic blood pressure, and lipids either individually or together rendered the relationships between worsening and CV outcomes nonsignificant.

CONCLUSIONS
Both the severity of retinopathy and its progression are determinants of incident CV outcomes. The retina may provide an anatomical index of the effect of metabolic and hemodynamic factors on future CV outcomes.
Environmental Implications of Anesthetic Gases
Authors: Yasny Jeffrey S. , White Jennifer 
Published: December 2012

Abstract
For several decades, anesthetic gases have greatly enhanced the comfort and outcome for patients during surgery. The benefits of these agents have heavily outweighed the risks. In recent years, the attention towards their overall contribution to global climate change and the environment has increased. Anesthesia providers have a responsibility to minimize unnecessary atmospheric pollution by utilizing techniques that can lessen any adverse effects of these gases on the environment. Moreover, health care facilities that use anesthetic gases are accountable for ensuring that all anesthesia equipment, including the scavenging system, is effective and routinely maintained. Implementing preventive practices and simple strategies can promote the safest and most healthy environment.
Circular External Fixator–Assisted Ankle Arthrodesis following Failed Total Ankle Arthroplasty
Authors: McCoy Thomas H. , Goldman Vladimir , Fragomen Austin T. , Rozbruch S. Robert 
Published: December 2012

Background: Failed total ankle arthroplasty (TAA) often results in significant bone loss and requires salvage arthrodesis. This study quantified the bone loss following failed TAA and reports the outcome of seven arthrodesis reconstructions using the Ilizarov method. Methods: A retrospective review of ankle fusions was performed for failed TAA to collect the mode of implant failure, presenting limb length discrepancy (LLD), total bone defect, postarthrodesis LLD, and treatment type (shoe lift versus distraction osteogenesis) and amount (shoe lift or lengthening). Results: Four mechanical failures and three infections were found. Four of seven cases had prior revision TAAs. Four of seven patients were treated with tibiotalar arthrodesis; three of the seven patients required talar resection and tibiocalcaneal arthrodesis. The mean presenting LLD was 2.2 (range, 1.2 to 3.5) cm. The mean time in frame was 197 (range, 146 to 229) days. With a mean postexplantation total bone defect of 5.1 (range, 3.7 to 8.5) cm, four of seven patients elected tibial lengthening following fusion [mean lengthening 4.6 (range, 2.5 to 8.0) cm; external fixation index (EFI) 42.6 (range, 16.5 to 55.6) days/cm)]. Three of seven patients were treated with a shoe lift [mean lift height 2.9 (range 2.5 to 3.2) cm]. There was no failure of fixation, refracture, or infection. All patients had a stable plantigrade foot and walked with minimal limp. Association for the Study and Application of the Method of Ilizarov (ASAMI) functional scores were six good and one fair. ASAMI bone scores were four excellent and three good. Conclusions: Ankle arthrodesis following failed TAA results in large LLDs secondary to bone loss during implant failure and subsequent explantation. External fixation can produce an excellent fusion rate in complex, possibly infected, failed TAAs. Limb length equalization (by either distraction osteogenesis or shoe lift) provides a means of obtaining good functional outcomes following failed TAA. Level of Evidence: IV, Retrospective Case Series
Convection-enhanced delivery of topotecan into diffuse intrinsic brainstem tumors in children
Authors: Anderson Richard C. E. , Kennedy Benjamin , Yanes Candix L. , Garvin James , Needle Michael , Canoll Peter , Feldstein Neil A. , Bruce Jeffrey N. 
Published: December 2012

Convection-enhanced delivery (CED) for the treatment of malignant gliomas is a technique that can deliver chemotherapeutic agents directly into the tumor and the surrounding interstitium through sustained, low-grade positive-pressure infusion. This allows for high local concentrations of drug within the tumor while minimizing systemic levels that often lead to dose-limiting toxicity. Diffuse intrinsic pontine gliomas (DIPGs) are universally fatal childhood tumors for which there is currently no effective treatment. In this report the authors describe CED of the topoisomerase inhibitor topotecan for the treatment of DIPG in 2 children.
As part of a pilot feasibility study, the authors treated 2 pediatric patients with DIPG. Stereotactic biopsy with frozen section confirmation of glial tumor was followed by placement of bilateral catheters for CED of topotecan during the same procedure. The first patient underwent CED 210 days after initial diagnosis, after radiation therapy and at the time of tumor recurrence, with a total dose of 0.403 mg in 6.04 ml over 100 hours. Her Karnofsky Performance Status (KPS) score was 60 before CED and 50 posttreatment. Serial MRI initially demonstrated a modest reduction in tumor size and edema, but the tumor progressed and the patient died 49 days after treatment. The second patient was treated 24 days after the initial diagnosis prior to radiation with a total dose of 0.284 mg in 5.30 ml over 100 hours. Her KPS score was 70 before CED and 50 posttreatment. Serial MRI similarly demonstrated an initial modest reduction in tumor size. The patient subsequently underwent fractionated radiation therapy, but the tumor progressed and she died 120 days after treatment.
Topotecan delivered by prolonged CED into the brainstem in children with DIPG is technically feasible. In both patients, high infusion rates (> 0.12 ml/hr) and high infusion volumes (> 2.8 ml) resulted in new neurological deficits and reduction in the KPS score, but lower infusion rates (< 0.04 ml/hr) were well tolerated. While serial MRI showed moderate treatment effect, CED did not prolong survival in these 2 patients. More studies are needed to improve patient selection and determine the optimal flow rates for CED of chemotherapeutic agents into DIPG to maximize safety and efficacy. Clinical trial registration no.: NCT00324844.
Outcome after arthroscopic treatment of lateral femoral trochlear ridge osteochondrosis in sport horses
Authors: UpRichard K. , Piat P. , Beauchamp G. , Laverty S. , Elce Y. A. 
Published: December 2012

SummaryObjectives: To determine the short- and long-term outcome for sport horses after arthroscopic treatment of osteochondrosis of the lateral trochlear ridge of the femur.Methods: A retrospective study was performed using the medical records of horses intended for use as English sport horses. Outcome was obtained through telephone questionnaire.Results: Thirty-seven horses, mainly Warmbloods, underwent arthroscopic surgery for treatment of lateral femoral trochlear ridge osteochondrosis. Short-term outcome revealed that 27 of 37 horses had no complications. Seven horses had postoperative lameness and effusion which eventually resolved in four horses. Long-term outcome was available for 29 horses, of which 19 were performing to full expectations. Five horses were athletic but at a lower level than expected, and five horses were unable to be used. The depth of the lesion was significantly associated with short-term complications of effusion and lameness. The depth and length of the lesion were not associated with the long-term outcome, but involvement of structures other than the lateral trochlear ridge (patella, medial trochlear ridge) was associated with a worse prognosis.Clinical significance: The prognosis for sport horses following stifle arthroscopy for lateral trochlear ridge is similar to that reported in other studies and lesions at other sites within the stifle joint.
Foreign body reaction to a retained surgical sponge (gossypiboma) mimicking an implant associated sarcoma in a dog after a tibial plateau levelling osteotomy
Authors: Cavanaugh R. P. , Fick J. L. , McAbee K. P. , Powers B. , Corbin E. E. 
Published: December 2012

SummaryA dog was presented with the complaint of an acute onset left pelvic limb lameness three years after a right tibial plateau levelling osteotomy had been performed. Radiographs taken at the time of presentation showed signs that were consistent with a diagnosis of an implant associated sarcoma. At revision surgery, a retained surgical sponge was identified, leading to a diagnosis of a gossypiboma. This is the first reported case of a gossypiboma as a complication of a tibial plateau levelling osteotomy surgery.
Airway injury associated with cervical bite wounds in dogs and cats: 56 cases
Authors: Halfacree Z. J. , Tivers M. S. , Jordan C. J. 
Published: December 2012

SummaryObjective: To investigate the frequency of airway injury and damage to other vital structures associated with cervical bite wounds in dogs and cats and the implications for management and outcome.Methods: A retrospective search of electronic patient records was used to identify dogs and cats suffering cervical bite wounds that were presented to a large multidisciplinary veterinary hospital over a four year period.Results: Complete records were available for 55 animals, with one animal suffering two separate injuries. Fourteen animals (25%) had injuries to vital structures, including airway injury in nine (17%) which was surgically confirmed and treated in six (11%). Airway injuries were associated with either subcutaneous or mediastinal emphysema in all affected animals. Other structures injured included the jugular vein, pharynx, oesophagus and spine. Airway injuries were treated with primary repair in five animals and a fasciomuscular patch in one. Temporary tracheostomy was performed in three animals. Median duration of hospitalisation was one day (0-19) with 53 animals (54 cases) (96%) surviving to discharge. Long-term follow-up (16-114 months) revealed that 43 of 49 animals were alive with six that died due to unrelated reasons.Clinical significance: Cervical bite wounds are associated with significant injury to vital structures. Up to 17% of animals may have injury to their airway. Identification and treatment of airway injury is vital and was associated with an excellent outcome in six animals.
Semeando o antropofagismo na produção acadêmica institucionalista brasileira em administração a partir de abordagem interdisciplinar
Authors: Justen Carlos Eduardo , Neto Luís Moretto , Garrido Paulo Otolini , Rodrigues Leonel Cezar 
Published: December 2012

Este estudo teórico tem o objetivo de demonstrar uma brasileiros em administração: a do holindividualismo, a partir de abordagem interdisciplinar. Neste trabalho, demonstra-se que, além do predomínio anglosaxão nos estudos neoinstitucionalistas brasileiros no campo da Administração, é dado destaque à orientação sociológica em detrimento de outras perspectivas teóricas, como a do neoinstitucionalismo histórico e econômico. A partir da discussão de dois elementos estruturantes do neoinstitucionalismo – instituição e legitimidade – revisita-se o momento da produção acadêmica institucionalista brasileira em administração para, como desfecho, advogar-se o antropofagismo: à importação intelectual devem ser conferidos significado, cor, valor e matiz locais.
Erratum
Authors: Cohn Ellen R. 
Published: December 2012

Correction to: Schutte, J., Gales, S., Filippone, A., Saptono, A., Parmanto, B., & McCue, M. (2012). Evaluation of a telerehabilitation system for community-based rehabilitation. International Journal of Telerehabilitation, 4(1), 25-32. doi:10.5195/ijt.2012.6092 For the article listed above, the names of authors Bambang Parmanto and Ashlee Filippone had been cited incorrectly in the: Accessible Table of Contents (rtf) doi: 10.5195/ijt.2012.6085; Table of Contents (pdf) doi: 10.5195/ijt.2012.6085; and online abstract.
Characterization of GPX1 and DIO1 Genes in Bubalus Bubalis
Authors: Dureja Vandana , Singh Sumer , Rana S , Banerjee P , Joshi J , Tantia M S , Vijh R K 
Published: December 2012

Selenoprotein genes contain selenium in the form of selenocysteine which is involved in protecting the cells from oxidative stress. Soils in India differ greatly in selenium concentrations affecting feed stuffs for selenium availability. Selenoproteins have recently been identified in variety of living organisms including humans which have 25 selenoprotein genes. Among these families of selenoprotein genes, we sequenced Gpx1 gene (Glutathione peroxidases1) and Dio1 gene (Iodothyronine deiodinases) in Bubalus bubalis. Gpx1 is most abundant and ubiquitously expressed selenoprotein which helps to protect against the damaging effects of hydrogen peroxide and oxygen rich free radicals whereas Dio1 is expressed mainly in liver, thyroid gland and adipose tissue, its main function is to convert tetraiodothyronine (T4) to its active form thyroxine (T3) in the presence of deiodinases enzyme. The main aim of the study was to characterize these two genes and to find out the buffalo specific SNPs. This was accomplished by designing primers using cattle database and sequencing a panel of 24 samples consisting of 6 diverse breeds of buffalo. Gpx1 consisted of 2 exons (Accession ID: JQ031269) while Dio1 comprised 4 exons (Accession ID: JQ791197). In Gpx1 gene, 9 SNPs were recorded and 4 were non synonymous, changing amino acid were distributed equally in both exon. In exon 1, A141G (aa Q5R) and G161A (aa A12T); and in exon 2 C785T (aa R132W) and A808T (aa S139R). In Dio1 gene, 3 non synonymous SNPs were identified at A188G (aa H22R), C215G (aa T31R) and G941A (aa V146I). These SNPs are novel and reported for the first time in Indian buffalo and has a potential for their use in diversity analysis and association with various selenium related traits.
Canein the Magazines:
Authors: Dahn Eurie 
Published: December 2012

ABSTRACTWhile critics have puzzled over and tried to explain the formal experimentation of Jean Toomer's Cane, the text's embeddedness in global periodical networks has been mostly overlooked. Toomer's writings, before and after Cane, were published in periodicals, particularly modernist little magazines and The Crisis magazine, and I argue that analyses of Cane's hybrid form must take into account Toomer's publication of portions of Cane in various magazines before publishing it as a book. Reading Cane through the lens of periodical studies reanimates our understanding of the text, its readership, and the periodicals in the context of regional, national, and global networks.
Do Illustrations Improve Children's Comprehension of Assent Documents?
Authors: Adcock Kim G. , Hogan Shirley M. , Elci Okan U. , Mills Keri L. 
Published: December 2012

OBJECTIVE
The purpose of this study was to assess children's comprehension of a new assent booklet, (KidSent), which uses pictures and written information.

STUDY DESIGN
A randomized, crossover study evaluated the comprehension of assent documents by children, 7 to 11 years of age at a local elementary school. The two types of documents tested were the standard assent form and the KidSent Assent Booklet. Participants were randomized as to which test document they received first by using a cluster randomization design. Participants read the document and then took a short quiz. The process was repeated for the other document on a separate day. Study participants were assigned a percentage score and a binary perfect score for each quiz. Mixed effects logistic and linear regression models with random intercepts were applied to the continuous percent quiz scores and binary perfect quiz scores, respectively.

RESULTS
A total of 190 participants completed the standard quiz, and 195 students completed the booklet quiz. A statistically significant difference in perfect quiz scores (p=0.004) and percent quiz scores (p≤0.001) between booklet and standard form was noted.

CONCLUSIONS
The quiz scores may indicate that the style of document is not the only factor influencing participant understanding.
Improving the Delivery of Patient Education about Kidney Transplant in a Transplant Center
Authors: Wilson Rula , Brown Diane R. , Boothe Makini A. S. , Weng Francis L. 
Published: December 2012

Context Kidney transplant is usually the best treatment option for patients with end-stage renal disease; however, transplant rates remain low in the United States. More research is needed about patients' educational needs to ensure that patients are making informed decisions about their treatment options. Objective To examine patients' perceptions of the delivery and format of a kidney transplant education program in a clinical setting, specifically to (1) identify useful aspects of the transplant education process, (2) discuss aspects of the program delivery that need improvement, and (3) provide recommendations to enhance the education delivery and format surrounding kidney transplant. Design A descriptive study using focus group meetings with patients at different stages of the transplantation process (in evaluation, listed, and transplant recipients). Data were analyzed by using thematic content analysis. Results Use of printed materials and handouts, group education format, and patient advocate component as well as bringing a companion were all effective aspects of the education program. Concerns about the education program stemmed from its complexity, technicality, and length. Participants recommended that patients be sent a formal invitation letter, with a detailed agenda and a video on kidney transplant, and that patients be encouraged to bring a companion to the education program. Responses specific to the stage of the transplant process are presented. Conclusion Concentrated attention to the delivery and content of the transplant education programs may significantly assist with patients' outcomes throughout the transplant process.
L’apprentissage professionnel des enseignants stagiaires de l’enseignement agricole français durant le stage de pratique accompagnée
Authors: Garcia Audrey 
Published: December 2012

Cet article qui s’inscrit dans une approche sociocognitive étudie l’apprentissage professionnel des enseignants stagiaires de l’enseignement agricole français durant le stage de pratique accompagnée. Son objectif est de montrer que l’enseignant stagiaire construit et mobilise dans l’interaction sociale avec son conseiller pédagogique des savoirs professionnels relatifs à la prise en charge des « tâches professionnelles ». À partir d’une méthodologie qualitative, cette étude présente les résultats d’une enquête menée auprès de sept stagiaires et six conseillers pédagogiques. L’article étudie les interrelations entre la nature des savoirs professionnels en question et les processus de construction à l’oeuvre.
Reproductive patterns among mothers of males diagnosed with Duchenne or Becker muscular dystrophy
Authors: Nabukera Sarah K. , Romitti Paul A. , Caspers Kristin M. , Street Natalie , Cunniff Christopher , Mathews Katherine D. , Fox Deborah J. , Puzhankara Soman , Ciafaloni Emma , James Katherine A. , Su Yin ,   the MD STARnet
Published: December 2012

AbstractDiagnosis of a child with Duchenne or Becker muscular dystrophy (DBMD) may impact future maternal reproductive choice; however, little is known about the reproductive patterns of mothers with a male child diagnosed with DBMD. Using population‐based surveillance data collected by the muscular dystrophy surveillance, tracking, and research network, the proportion of mothers who conceived and delivered a live birth following the diagnosis of DBMD in an affected male child and factors associated with such reproductive choice were identified. To accomplish this, maternal demographic data were linked to birth certificate data to construct the reproductive history for 239 mothers. Univariable and bivariable analyses were conducted to determine the proportion of mothers delivering a live birth and associated factors. By the time of the current study, 96 (40.2%) of the 239 mothers had at least one live birth following delivery of their oldest affected male child; 53 (22.2%) of these mothers had a live birth before and 43 (18.0%) had a live birth after DBMD diagnosis of a male child. Mothers with a live birth after diagnosis were significantly younger at diagnosis of the oldest affected male child (26.2 ± 4.2 years vs. 31.5 ± 5.5 years), and were less likely to be white non‐Hispanic compared to those with no live birth after diagnosis. These results suggest that about one in five mothers deliver a live birth subsequent to DBMD diagnosis in a male child. Maternal age and race/ethnicity were associated with this reproductive choice. © 2012 Wiley Periodicals, Inc.
Uterine structural anomalies and arthrogryposis—death of an urban legend
Authors: Hall Judith G. 
Published: December 2012

AbstractIn a review of 2,300 cases of arthrogryposis collected over the last 35 years, 33 cases of maternal uterine structural anomalies were identified (1.3%). These cases of arthrogryposis represent a very heterogeneous group of types of arthrogryposis. Over half of individuals affected with arthrogryposis demonstrated asymmetry and some responded to removal of constraint, 29 of the 33 cases of arthrogryposis whose mother had a uterine structural anomaly could be identified as having a specific recognizable type of arthrogryposis. Only two cases (0.08%) had primarily proximal contractures that returned to almost normal function within 1 year. Craniofacial asymmetry was the most striking finding in these two cases. A quarter of cases had ruptured membranes between 32 and 36 weeks and either oligohydramnios or prematurity. The pregnancy histories of the mothers with uterine structural anomalies were typical in having infertility, multiple miscarriages, and stillbirths. The finding of only two cases which are likely to have multiple congenital contractures on the basis of uterine constraint suggests that it is a very rare primary cause of arthrogryposis. © 2012 Wiley Periodicals, Inc.