bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of diseases complicating long COVID: A retrospective chart review
Authors: Tsuchida Tomoya , Hirose Masanori , Fujii Hirotoshi , Hisatomi Ryunosuke , Ishizuka Kosuke , Inoue Yoko , Katayama Kohta , Nakagama Yu , Kido Yasutoshi , Matsuda Takahide , Ohira Yoshiyuki 
Published: July 2024

AbstractBackgroundEvidence for the pathogenesis and treatment of postacute coronavirus disease 2019 (COVID‐19) (long COVID) is lacking. As long COVID symptoms are predicted to have an impact on the global economy, clarification of the pathogenesis is urgently needed. Our experiences indicated that some symptoms were complicated by diseases established before the COVID‐19 pandemic.MethodsUsing a retrospective, cross‐sectional study, we aimed to evaluate the diseases complicating long COVID. Using the medical records of patients with confirmed COVID‐19 exhibiting residual symptoms lasting ≥60 days postinfection who visited our clinic in January 2021–February 2023, we investigated the symptoms and diseases observed. We identified diseases that occurred after COVID‐19 and excluded those that were exacerbations of existing diseases.ResultsDuring the first visit, the most common symptoms reported in a total of 798 patients were fatigue (523 patients), anxiety (349 patients), and lack of motivation (344 patients). Complicating diseases were observed in 452 patients (57%). There were 115, 65, and 60 patients with postural tachycardia syndrome, postural syndrome without tachycardia, and mood disorders, respectively. Some diseases requiring immediate treatment included pulmonary thromboembolism, purulent shoulder arthritis, cerebellopontine angle tumors, myasthenia gravis, and cervical myelopathy.ConclusionNot all symptoms that occur after COVID‐19 should be treated as long COVID. Similar to normal medical treatment, a list of differential diagnoses should be maintained based on symptoms to obtain definitive diagnoses.
Analysing public policies for the creative economy: A systematic literature review
Authors: da Silva Ana Maria Vicente , Muzzio Henrique , da Silveira Denis Silva 
Published: July 2024

AbstractThis paper seeks to conduct a comprehensive literature review analysing governmental initiatives, particularly public policies, pertaining to the needs of the creative economy (CE). The uniqueness of this paper lies in its unprecedented examination of literature on governmental actions for the CE. The methodology involved executing a rigorous systematic review of literature drawn from multiple credible research sources. The primary objective was to identify the stimuli, impediments and formulation processes across various sectors within the CE. The findings uncover a wide array of stimuli that policymakers can employ to foster the CE. We offer recommendations for constructing a policy framework.
Eosinophilic myenteric ganglionitis: A case in a 14‐year‐old‐male
Authors: Price Anthony , Rastegarlari Tandis , Khowaja Sanober , Thompson Kade , Lahiji Arian P. , Felicella Michelle M. , He Jing , Goodwin Annie 
Published: July 2024

AbstractChronic intestinal pseudo‐obstruction (CIPO) is a rare, severe, and often debilitating condition that can result in significant morbidity and mortality amongst the pediatric population. Eosinophilic myenteric ganglionitis (EMG) is a rare inflammatory neuropathy of the myenteric plexus with characteristic eosinophilic infiltration with and without hypogangliosis. The disorder has been previously documented as a cause of CIPO. We report the case of a 14‐year‐old male with no clear obstructive cause who, after multiple visits with a myriad of tests and workups, underwent surgical exploratory laparoscopy with the pathology returning a diagnosis of EMG with unique lymphocytic and eosinophilic cell components.
Microscopic growth of pyridinium oxime based amphipathic on graphite: Effect of relative position of substituents
Authors: Chauhan Poonam , Saha Prithwidip , Gopakumar Thiruvancheril G. , Ramapanicker Ramesh 
Published: July 2024

AbstractAmphipathic molecules with surfactant like properties have several applications ranging from healthcare to the chemical industry. Their ability to form thin films on surfaces with ordered and controllable patterns determines their applicability. Here, we report two pyridinium oxime‐based surfactants, which possess similar aggregation properties in solution, but exhibit substantially different assembly on highly oriented pyrolytic graphite (HOPG) surface. The two compounds are regioisomers with the oxime unit placed either in meta or para position of the pyridinium ring. While the para isomer assembled to anisotropic one‐dimensional (1D) islands and long rod‐like structures, the meta isomer formed two‐dimensional (2D) islands on the HOPG surface. This difference is rationalized through molecular level force‐field calculations that show anisotropy in the growth of the para isomer resulting from an effective overlap of the alkyl chains and oxime groups, which is distinctly not feasible in the assembly of the meta isomer. The assembly of these compounds is compared with another oxime‐containing compound of similar structure, but without the charged pyridinium unit. The charged unit seems to be crucial for the preferential formation of multilayer islands even at low coverage.
Immune checkpoint expression as prognostic biomarker candidates in non‐small cell lung carcinoma patients
Authors: Porto Débora Maria , Costa Guilherme Jorge , Torres Leuridan Cavalcante , Casarini Dulce Elena 
Published: July 2024

AbstractBackgroundCancer immunotherapy has had an important role in oncologic therapeutics for patients with non‐small cell lung cancer (NSCLC) using checkpoint inhibitors. We will explore the possible prognosis biomarker candidates such as: soluble OX40 (sOX40), OX40L (sOX40L), Glucocorticoid‐induced tumor necrosis factor receptor family‐related receptor (GITR), and their ligand (GITRL), 4‐1BB or tumor necrosis factor receptor superfamily 9 (TNFRS9) and inducible T cell co‐stimulator (ICOS) in peripheral blood of NSCLC patients.MethodsFifty‐eight patients were diagnosed with advanced NSCLC between January 2019 and March 2020.ResultsHigh sOX40 and low s4‐1BB levels in smokers compared non‐smoker NSCLC patients. Lower sOX40L levels were found in the male than female (p < 0.05). High sOX40 and sGITRL in stage III compared to the stage IV (p < 0.05). With follow‐up at 21.4 months, 44.1% and 91.1% were alive in the sGITRhigh and sGITRlow groups, respectively (p = 0.02), and 73.3% and 27.7% were alive in the sGITRLhigh and sGITRLlow groups, respectively (p = 0.02). At 22 months, 38.7% and 92.3% were alive in the sOX40Lhigh and sOX40Llow groups, respectively (p = 0.01).ConclusionsGITR, sGITRL, and sOX40L levels were potential prognostic biomarkers and could have an important role as new targets of immunotherapy in NSCLC patients. sGITR, sGITRL, sOX40L, and sOX40 levels were associated with smoking, sex, stage, and age in NSCLC.
Concentration of High‐Cost Head and Neck Cancer Surgical Patients
Authors: Garcia Jordan , Yesantharao Lekha , Frick Kevin D. , Fakhry Carole , Koch Wayne , Mydlarz Wojtech , Eisele David W. , Gourin Christine G. 
Published: July 2024

ObjectiveHealth care costs are disproportionately concentrated among a small number of patients. We sought to identify variables associated with high‐cost patients and high hospital concentration of high‐cost patients and to examine associations with short‐term outcomes in head and neck cancer (HNCA) surgery.Study DesignThe Nationwide Inpatient Sample was used to identify 170,577 patients who underwent HNCA surgery in 2001–2011. High‐cost patients were defined as patients whose costs of care were in the top decile, and high‐concentration hospitals were defined as those whose percentage of high‐cost patients was in the top decile.MethodsMultivariable regression was used to evaluate associations between cost and patient and hospital variables, postoperative complications, and in‐hospital mortality.ResultsCosts associated with high‐cost patients were 4.47‐fold greater than the remaining 90% of patients. High‐concentration hospitals treated 36% of all high‐cost patients. High‐cost patients were more likely to be non‐white (OR = 2.08 [1.45–2.97]), have oral cavity cancer (OR = 1.21 [1.05–1.39]), advanced comorbidity (OR = 1.53 [1.31–1.77]), Medicaid (OR = 1.93 [1.62–2.31]) or self‐pay payor status (OR = 1.72 [1.38–2.14]), income>50th percentile (OR = 1.25 [1.05–1.51]), undergo major procedures (OR = 3.52 [3.07–4.05]) and have non‐routine discharge (OR = 7.50 [6.01–9.35]). High‐concentration hospitals were more likely to be teaching hospitals (OR = 3.14 [1.64–6.05]) and less likely to be urban (OR = 0.20 [0.04–0.93]). After controlling for all other variables, high‐cost patients were associated with an increased odds of mortality (OR = 8.00 [5.89–10.85]) and postoperative complications (OR = 5.88 [5.18–6.68]). High‐concentration hospitals were associated with an increased odds of postoperative complications (OR = 1.31 [1.08–1.61]) but were not associated with increased mortality (OR = 0.98 [0.67–1.44]).ConclusionsHigh‐cost HNCA surgical patients are associated with increased postoperative morbidity and mortality, and are disproportionately concentrated at teaching hospitals.Level of Evidence4 Laryngoscope, 134:4971–4978, 2024
“Quantifying the Impacts of Multiple Stressors” (QIMS)—a new experimental platform for robust multifactorial experiments in benthic ecosystems
Authors: Schertenleib Katrin , Fitzpatrick Robert , O'Connor Nessa E. 
Published: July 2024

AbstractTo predict the ecological consequences of expected global change, we need to understand the independent and combined effects of multiple stressors. Multiple experimental treatments are required to simultaneously test for effects of multiple stressors at different levels of intensity, independently and combined, and at different levels of biological organization. Most marine multiple stressors studies to date are conducted on assembled communities in mesocosms with a low number of treatments or low replication of treatments or both. These limitations prevent (1) robust data analyses, (2) characterization of single and combined effects of multiple stressors, and (3) identification of mechanisms underpinning biological responses. We present a new mesocosm‐based experimental platform for benthic communities: Quantifying the Impacts of Multiple Stressors (QIMS). Here, 96 independent mesocosms facilitate multifactorial and multilevel experimental designs with the high replication required for robust tests of multiple stressors and biological interactions. For example, three distinct pH levels are achieved by manipulating CO2 concentrations in the air supply, and three water temperature levels are provided by a cooling system in a fully crossed design that is required to identify all potential interactions, from which all combinations can be replicated 10 times (i.e., 90 experimental units). We demonstrate clearly how different levels of temperature and pCO2/pH can be manipulated precisely and maintained for at least 7 weeks. QIMS complements the limited number of permanently installed marine mesocosm facilities worldwide that simulate ocean warming and/or acidification and expedites multiple stressor research by providing an unprecedented level of replication for statistical robustness.
Size normalizing planktonic Foraminifera abundance in the water column
Authors: Chaabane Sonia , de Garidel‐Thoron Thibault , Giraud Xavier , Meilland Julie , Brummer Geert‐Jan A. , Jonkers Lukas , Mortyn P. Graham , Greco Mattia , Casajus Nicolas , Kucera Michal , Sulpis Olivier , Kuroyanagi Azumi , Howa Hélène , Beaugrand Gregory , Schiebel Ralf 
Published: July 2024

AbstractPlanktonic Foraminifera have been collected from the water column with different plankton sampling devices equipped with nets of various mesh sizes, which impedes direct comparison of observed quantifications. Here, we use data on the community size structure of planktonic Foraminifera to assess the impact of mesh size on the measured abundance (ind m−3) of planktonic Foraminifera. We use data from the FORCIS database (Chaabane et al., 2023, Scientific Data 10: 354) on the global ocean at different sampling depths over the past century. We find a global cumulative increase in abundance with size, which is best described using a Michaelis–Menten function. This function yields multiplication factors by which one size fraction can be normalized to any other size fraction equal to or larger than 100 μm. The resulting size normalization model is calibrated over a range of different depth intervals, and validated with an independent dataset from various depth ranges. The comparison to Berger's (1969, Deep. Res. Oceanogr. Abstr. 16: 1–24) equivalent catch approach shows a significant increase in the predictive skill of the model. The new size normalization scheme enables comparison of Foraminifera abundance data sampled with plankton nets of different mesh sizes, such as compiled in the FORCIS database. The correction methodology may be effectively employed for various other plankton groups such as diatoms and dinoflagellates.
Prescription Drug Utilization among Patients with Essential Tremor: A Cross‐Sectional Study of More Than 36,000 Patients
Authors: Kapinos Kandice A. , Louis Elan D. 
Published: July 2024

AbstractBackgroundEssential tremor (ET) is a chronic, progressive neurological disease that affects an estimated 7 million individuals in the United States (ie, 2.2% of the entire U.S. population). Despite its high prevalence, there are a few published studies on patterns of prescription medication use among patients.ObjectiveThe aim was to examine prescription drug medication use among ET patients.MethodsThis is a cross‐sectional study of ET patients, age ≥40, with at least 1 prescription medication fill using the Optum's de‐identified Clinformatics Data Mart Database from 2018 through 2019. We examined patterns of fills of key agents used to treat ET.ResultsThe final sample comprised 36,839 ET patients in the United States; 89% had at least 1 prescription drug claim over a 2‐year period, indicating that 9 of 10 ET patients take a medication to treat their disease. For each of the 3 most frequently prescribed medications, only a modest fraction (1/5 to 1/4) of patients were taking that medication. Adherence to these agents was 52% to 61%. A high percentage of patients had fills for more than 1 of the main agents we studied.ConclusionThese data illustrate a need for medication in the ET population. There is only 1 FDA‐approved medication to treat ET, propranolol, and less than 25% of ET patients used this drug during our study period. At the same time, no single agent was utilized by more than one quarter of ET patients, adherence was low, and use of multiple agents was common. For such a common disease, the pharmacotherapeutic landscape is impoverished.
Impact of policy interventions on low‐carbon technology innovation diffusion in supply networks
Authors: Wang Zehao , Feng Yu , Yao Nana , Lin Ouwen , Li Qiyuan , Liu Bowen 
Published: July 2024

AbstractThe promotion of sustainability and innovation in the current dynamic landscape of global industry in the context of climate change has become imperative. This research paper explores the critical role of policy interventions in facilitating the diffusion of low‐carbon technologies through intricate supply networks. As countries endeavor to meet environmental goals and transition to a more sustainable economy, it becomes critical to understand how policies can effectively shape the diffusion of these technologies through the supply chain. This study employs game theory and evolutionary game theory to investigate the intricate interactions within supply networks, with a particular focus on the nuanced effects of policy on the diffusion of low‐carbon technology innovations. The findings suggest that dynamically adjusted policies have the potential to significantly increase the uptake of low‐carbon technologies. In particular, an effective subsidy scheme not only promotes the diffusion of innovations, but also demonstrates the ability of government subsidies to be distributed efficiently. In addition, the implementation of dynamic carbon trading schemes is considered to be an important mechanism for promoting firms' decarbonization and stabilizing strategic decision‐making processes within firms. This study highlights the significance of tailored dynamic policy frameworks in promoting the adoption of sustainable technologies in supply chains, thus making a significant contribution to the broader goal of achieving a sustainable future.
The Relationship between Diet, Depression, and Alzheimer's Disease: A Narrative Review
Authors: Al Shamsi Hilal Salim Said , Rainey‐Smith Stephanie R. , Gardener Samantha L. , Sohrabi Hamid R. , Canovas Rodrigo , Martins Ralph N. , Fernando Warnakulasuriya Mary Ann Dipika Binosha 
Published: July 2024

Purpose of ReviewThis narrative review evaluates the role of diet in the relationship between depression and Alzheimer's disease (AD).Recent FindingsAD and depression are often comorbid, and depression appears to independently increase the future risk of AD. Evidence suggests diet influences the risk of both conditions directly and indirectly. Diet impacts neurochemical and biological processes that may affect the development and progression of depression and cognitive dysfunction. The dietary components offering the greatest protection against depression and AD are yet to be determined. Current evidence highlights the importance of polyphenolic compounds, folate, B vitamins, and polyunsaturated fatty acids, along with adherence to dietary patterns like the Mediterranean diet, which includes multiple beneficial dietary factors.SummaryThe investigation of dietary factors in the prevention of depression and AD is a comparatively young field of research. Comprehensive highly characterised longitudinal datasets and advanced analytical approaches are required to further examine the complex relationship between diet, depression, and AD. There is a critical need for more research in this area to develop effective preventive strategies aimed at maintaining mental and physical health with advancing age.
A new, standardized international Pacific Rim baseline for genetic stock identification (GSI) of Chinook Salmon
Authors: Van Doornik Donald M. , Moran Paul , Rondeau Eric B. , Nichols Krista M. , Narum Shawn R. , Campbell Matthew R. , Clemento Anthony J. , Hargrove John S. , Hess Jon E. , Horn Rebekah L. , Seeb Lisa W. , Stephenson Jeff J. , McKinney Garrett J. 
Published: July 2024

Abstract

Objective
Genetic stock identification (GSI) can be an effective tool for fisheries management, but development of reference baselines for species with broad geographic distributions can be challenging. Mixed-stock fisheries for Chinook Salmon Oncorhynchus tshawytscha have utilized GSI analyses for decades with various genetic baselines, but these have largely become outdated with advances in technology that enable more efficient genotyping. Thus, our goals were to (1) create nested baselines of genotypic data for Chinook Salmon throughout their entire natural range using existing data from multiple sources and (2) evaluate the utility of those nested baselines to conduct accurate hierarchical GSI of mixture proportions or the stock identification of individual fish.

Methods
In this study, we compiled a large genetic baseline of single-nucleotide polymorphism (SNP) markers for 389 populations that encompass the entire geographic range of Chinook Salmon. We used cross validation and realistic mixture simulations to test the accuracy of the baseline in generating GSI estimates.

Result
We demonstrated that a multi-tiered assignment approach can provide high accuracy at both tier 1 (broadscale, with three coastwide reporting groups; 97.8% mean accuracy) and tier 2 (fine-scale regional reporting groups; up to 97.7% mean accuracy) levels. Realistic mixture simulations showed that this multi-tiered approach can provide highly effective GSI results for several common mixed-stock fisheries applications in the Pacific Ocean.

Conclusion
This new SNP baseline and the multi-tiered assignment approach provide the most comprehensive rangewide GSI baseline for Chinook Salmon over any previous application and enable highly accurate estimates for GSI purposes.
Poly(ester amide) from 6‐amino‐1‐hexanol and terephthalic acid: preparation and properties
Authors: Xiao Liwen , Cheng Kan , Liu Tao , Xia Yumin , Wang Xueli , He Yong 
Published: July 2024

AbstractPoly(ester amide)s (PEAs) have received extensive attention due to their unique chemical structure and excellent properties. In this paper, a novel PEA (P6T6T) was prepared through melt polycondensation of terephthalic acid (PTA) and 6T6‐diamide‐diol (6T6), which was from the amidation of 6‐amino‐1‐hexanol and PTA. The structures were characterized by nuclear magnetic resonance, fourier transform infrared, and wide‐angle X‐Ray diffraction, and the thermal properties were evaluated by differential scanning calorimetry and thermal gravimetric analysis for P6T6T. It was found that the melting point of P6T6T was 217°C, which was about 37°C lower than that of PET (254°C), while the initial decomposition temperature was maintained at about 381°C. P6T6T had a fast crystallization rate (the half time of crystallization (t1/2) range from 35 to 60 s) and great crystallization properties. The saturated water absorption of the P6T6T was measured to be 2.53 wt%, which was three times that of PET (0.83 wt%). Furthermore, the water contact angle of P6T6T was determined to be 57.3°C, much lower than that of PET (94.7°C). All these results suggest that the incorporation of amide was an efficient method to improve the water absorption of polyester fibers.
Largely enhanced high‐temperature energy storage performance of P(VDF‐HFP) dielectric films via calcium niobate nanosheets
Authors: Lin Zhiming , Bao Zhiwei , Wang Baoyuan , Wang Bingbo , Wang Ziquan , Han Donglin , Qiang Yu , Hou Ying , Li Xiaoguang 
Published: July 2024

AbstractThe capacitive energy‐storage capacity of most emerging devices rapidly diminishes with increasing temperature, making high‐temperature dielectrics particularly desirable in modern electronic systems. In this work, calcium niobate (Ca2Nb3O10, CNO) nanosheets have been added into poly(vinylidene fluoride‐hexafluoropropylene) (P(VDF‐HFP), PVHP), forming PVHP/CNO nanocomposites with exceptional temperature stability and ultrahigh energy storage density. Especially, at 80°C and 450 MV/m, the PVHP/0.3 wt%CNO nanocomposite shows an excellent Wrec of 10.81 J/cm3 which is higher than previous PVDF‐based composite films at high temperatures. Because of the high dielectric permittivity of CNO nanosheets and the way that the parallel organization of the nanosheets blocks the course of electrical trees, nanocomposites exhibit greater dielectric constants and breakdown field strengths simultaneously. These findings, will be helpful in the development of flexible, high‐energy‐density capacitors that have stable performance at high temperatures.Highlights
A record‐high high‐temperature Wrec is obtained.
Excellent temperature stability from 25 to 80°C is achieved.
The incorporation of Ca2Nb3O10 nanosheets significantly enhances Eb.