bluuebunny/crossref_metadata_2025_split huggingface dataset:
Achieving Long‐Range Arbitrary Uniform Alignment of Nanostructures in Magnetic Fields
Authors: Ghai Viney , Pandit Santosh , Svensso Magnus , Larsson Ragnar , Matic Aleksandar , Ngaloy Roselle , Dash Saroj P. , Terry Ann , Nygård Kim , Mijakovic Ivan , Kádár Roland 
Published: June 2024

AbstractFor magnetic field orientation of nonstructures to become a viable method to create high performance multifunctional nanocomposites, it is of paramount importance to develop a method that is easy to implement and that can induce long‐range uniform nanostructural alignment. To overcome this challenge, inspired by low field nuclear magnetic resonance (NMR) technology, a highly uniform, high field strength, and compact magnetic‐field nanostructure orientation methodology is presented for polymeric nanocomposites using a Halbach array, for the first time. Potential new advances are showcased for applications of graphene polymer composites by considering their electro‐thermal and antibacterial properties in highly oriented orthogonal morphologies. The high level of anisotropy induced in the graphene nanocomposites studied stands out through: 1) up to four decades higher electrical conductivities recorded in comparison to their randomly oriented counterparts, at concentrations where the latter show minimal improvements compared to the unfilled polymer; 2) over 1200% improvement in thermal conductivity, 3) antibacterial surfaces at field benchmark levels with lower filler content and with the added versatility of arbitrary orientation of the nanofillers. Overall, the new method and variations thereof can open up new horizons for tailoring nanostructure and performance for virtually all major nanocomposite applications based on graphene and other types of fillers.
Preferred Crystallographic Orientation via Solution Bathing for High‐Performance Inverted Perovskite Photovoltaics
Authors: Zhang Xinyue , Shang Chuanzhen , Wang Chenyun , Zhao Wenying , Tao Cong , Wang Shasha , Zhang Xuewen , Han Ruilin , Zhou Bin , Qu Duo , Wang Shibo , Wang Ying , Ke You , Tu Yongguang 
Published: June 2024

AbstractThe meticulous control of crystal facets in polycrystalline perovskite films offers valuable insights into the photoelectric properties, varying significantly with different orientations. Exploring effective means to regulate these facets is crucial, and further revealing the underlying mechanisms is needed. Here, the research employed green solution bathing to obtain high‐quality perovskite films with preferred crystallographic orientation. In brief, eco‐friendly 2‐pentanol is used as the solvent, and functional molecules 2‐(dimethylaminomethyl)‐4‐(2‐aminoethylthiomethyl)thiazole (DAT) are introduced into the solution bathing as the solute. By introducing DAT molecules, precise control over perovskite crystal nucleation kinetics is achieved, resulting in films with a preferential (100) facet orientation. Conversely, films without DAT exhibited distinct (111) facet orientation. The regulation of DAT on perovskite film crystal facet is verified through theoretical and crystallographic analyses. Theoretical calculations show that S atom of DAT binds most strongly to the (100) facet of FAPbI3, promoting surface energy reduction and thermodynamic enhancement, favoring (100) crystal orientation. Crystallographic characterization further proved the regulation effect. In addition, PL/TRPL tests confirm the regulation of DAT on superior photoelectric properties of (100)‐oriented perovskite films. The work introduces a novel approach and preparation process for regulating the crystal facets orientation of polycrystalline perovskite films.
Progress in the Computer‐Aided Analysis in Multiple Aspects of Nanocatalysis Research
Authors: Fan Lin , Shen Yilei , Lou Doudou , Gu Ning 
Published: June 2024

AbstractMaking the utmost of the differences and advantages of multiple disciplines, interdisciplinary integration breaks the science boundaries and accelerates the progress in mutual quests. As an organic connection of material science, enzymology, and biomedicine, nanozyme‐related research is further supported by computer technology, which injects in new vitality, and contributes to in‐depth understanding, unprecedented insights, and broadened application possibilities. Utilizing computer‐aided first‐principles method, high‐speed and high‐throughput mathematic, physic, and chemic models are introduced to perform atomic‐level kinetic analysis for nanocatalytic reaction process, and theoretically illustrate the underlying nanozymetic mechanism and structure‐function relationship. On this basis, nanozymes with desirable properties can be designed and demand‐oriented synthesized without repeated trial‐and‐error experiments. Besides that, computational analysis and device also play an indispensable role in nanozyme‐based detecting methods to realize automatic readouts with improved accuracy and reproducibility. Here, this work focuses on the crossing of nanocatalysis research and computational technology, to inspire the research in computer‐aided analysis in nanozyme field to a greater extent.
Advanced Energy Harvesters and Energy Storage for Powering Wearable and Implantable Medical Devices
Authors: Gao Ziyan , Zhou Yang , Zhang Jin , Foroughi Javad , Peng Shuhua , Baughman Ray H. , Wang Zhong Lin , Wang Chun H. 
Published: June 2024

AbstractWearable and implantable active medical devices (WIMDs) are transformative solutions for improving healthcare, offering continuous health monitoring, early disease detection, targeted treatments, personalized medicine, and connected health capabilities. Commercialized WIMDs use primary or rechargeable batteries to power their sensing, actuation, stimulation, and communication functions, and periodic battery replacements of implanted active medical devices pose major risks of surgical infections or inconvenience to users. Addressing the energy source challenge is critical for meeting the growing demand of the WIMD market that is reaching valuations in the tens of billions of dollars. This review critically assesses the recent advances in energy harvesting and storage technologies that can potentially eliminate the need for battery replacements. With a key focus on advanced materials that can enable energy harvesters to meet the energy needs of WIMDs, this review examines the crucial roles of advanced materials in improving the efficiencies of energy harvesters, wireless charging, and energy storage devices. This review concludes by highlighting the key challenges and opportunities in advanced materials necessary to achieve the vision of self‐powered wearable and implantable active medical devices, eliminating the risks associated with surgical battery replacement and the inconvenience of frequent manual recharging.
Glutathione‐Scavenging Celastrol‐Cu Nanoparticles Induce Self‐Amplified Cuproptosis for Augmented Cancer Immunotherapy
Authors: Lu Sheng , Li Yifan , Yu Yingjie 
Published: June 2024

AbstractCuproptosis is a novel copper‐dependent programmed cell death. The efficacy of cuproptosis is highly dependent on intracellular copper accumulation and counteracted by a high level of glutathione (GSH) in tumor cells. Here, this work develops a self‐amplified cuproptosis nanoparticles (Cel‐Cu NP) using celastrol (Cel), a natural product isolated from medical plant. In Cel‐Cu NP, Cel serves as a versatile copper ionophore, exhibiting an ideal coordination capacity toward copper ions without compromising the cuproptosis induction. Notably, Cel can simultaneously scavenge GSH content to amplify cuproptosis. Moreover, this self‐amplified cuproptosis further activates immunogenic cell death (ICD) to elicit robust immune response. Combining with immune checkpoint blockade, Cel‐Cu NP effectively eradicates metastatic tumors in a mouse lung metastasis model. This study provides an efficient nanomedicine by inducing self‐amplified cuproptosis for robust immunotherapy.
Cooperative In Situ Impregnation of PEG and Au Nanoparticles into Expanded CNT Network Toward Composite Phase Change Fibers with High Storage Capacity and Photothermal Conversion
Authors: Liao Tanqian , Li Wenya , Zhao Jingna , Yang Xiaoyu , Zhang Wentao , Zou Jingyun , Zhao Bing , Zhang Xiaohua , Li Qingwen 
Published: June 2024

AbstractPhase change fibers with multifunctionalities are a promising material for thermal management applications, however, it is still challenging to simultaneously give the fiber high energy conversion and storage capacity. Here, a cooperative in situ impregnation strategy is reported, to introduce Au nanoparticles (NPs) and polyethylene glycol (PEG) together into carbon nanotube (CNT) network during the expansion process, resulting in a CNT/Au/PEG composite phase change fiber. The obtained composite fiber have the characteristics of high loading (up to 88.0–98.6%) and uniform distribution of Au NPs, and thus exhibits superior mechanical, electrical, and thermal properties. The presence of Au NPs plays more important role in not only improving the PEG crystallinity and phase change enthalpy, but also enhancing the photothermal conversion efficiency (up to 88.2%). There is also a new feature of precise regulation of the phase change temperatures, e.g., from 9.5 to 20.5 °C for the solidification temperature. More importantly, due to the strong confinement of PEG and Au NPs inside the CNT network, the composite fiber also shows excellent thermal stabilities, including the anti‐leakage behavior and cycling phase change ability.
Hypermultiplexed Off‐Chip Hologram by On‐Chip Integrated Metasurface
Authors: Liu Xianjin , Ma Zhanying , Zhang Dasen , Bao Qiwen , Liu Zhenzhen , Xiao Jun‐Jun 
Published: June 2024

AbstractThe waveguide‐integrated metasurface introduces a novel photonic chip capable of converting guided modes into free‐space light. This enables functions such as off‐chip beam focusing, steering, and imaging. The challenge lies in achieving hyper‐multiplexing across diverse parameters, including guided‐wave mode type, direction, polarization, and notably, multiple wavelengths. Here, a comprehensive end‐to‐end inverse design framework is introduced, rooted in a physical model, for the multifunctional design of on‐chip metasurfaces. This framework allows for metasurface optimization through a target‐field‐driven iteration process. A hypermultiplexed on‐chip metasurface capable of generating red‐green‐blue holograms at multiple target planes is demonstrated, with both independent and cooperative control over guided‐wave direction. Significantly, the proposed method streamlines the design process utilizing only the positions of meta‐atoms as the design variable. Nine independent holographic channels are demonstrated through a combination of wavelength and distance multiplexing. Moreover, by incorporating the excitation direction into the design, the metasurface produces a total of 36 distinct holograms. The robustness of these results against fabrication discrepancies is validated through 3D full‐wave electromagnetic simulations, aligning well with advanced manufacturing techniques. The research presents a universal design framework for the development of multifunctional on‐chip metasurfaces, opening up new avenues for a wide range of applications.
Quantum‐Dots‐In‐Double‐Perovskite for High‐Gain Short‐Wave Infrared Photodetector
Authors: Jhang An‐Ting , Tsai Po‐Cheng , Tsai Yi‐Ting , Lin Shih‐Yen , Fang Mu‐Huai 
Published: June 2024

AbstractShort‐wave infrared (SWIR) photodetectors utilizing quantum dot (QD) material systems, harnessed through the quantum confinement effect to tune the absorption wavelength, offer an attractive avenue for the development of cost‐effective and solution‐processed photodetectors compared to the relatively expensive compound semiconductor photodetectors. However, the pores between the QDs and poor chemical stability after surface modification have impeded the practical application of quantum‐dot‐based photodetectors. In this study, high‐gain SWIR photodetector is demonstrated and achieved by incorporating PbS QD into the Cs2AgBiBr6 halide‐based double perovskite matrix, as confirmed by X‐ray diffraction, transmission electron microscope, and energy dispersive spectrometer. The thin film structure and detailed local structure are revealed by 2D grazing‐incidence wide and small‐angle X‐ray scattering. The resulting PbS@Cs2AgBiBr6‐based SWIR photodetector exhibits remarkable performance with a responsivity and detectivity of 15000 A W−1 and 1.31 × 1012 cm Hz1/2 W−1, respectively. This study offers valuable insights into the design of composite materials for high‐gain SWIR photodetectors.
Phase‐Shifted Bragg Gratings from High Refractive Index Chalcogenide Hybrid Inorganic/Polymers: Fabrication and Thermo‐Optic Characterization
Authors: Nishant Abhinav , Kim Kyung‐Jo , Himmelhuber Roland , Lee Taeheon , Kleine Tristan S. , Pyun Jeffrey , Norwood Robert A 
Published: June 2024

AbstractIn this study, the first fabrication of phase‐shifted Bragg gratings utilizing chalcogenide hybrid inorganic/organic polymers (CHIPs) is presented based on poly(sulfur‐random‐(1,3‐isopropenylbenzene) to measure the thermo‐optic coefficient (TOC) of this new class of optical polymers. The unique properties of CHIPs, such as high index contrast and low optical losses, are leveraged to fabricate Bragg gratings that enable precise determination of the TOC and glass transition temperature (Tg) of these polymers. The optical measurement introduces a novel technique to measure the TOC and Tg of optical polymers which can be difficult to determine using traditional methods such as differential scanning calorimetry (DSC) after fabrication into photonic device constructs. The findings demonstrate that CHIPs exhibit low thermo‐optic (TO) effects, making them exceptionally well‐suited for the development of thermally stable photonic integrated circuits.
Electrochemical α‐Functionalization of N‐Aryl‐Activated Tertiary Amines
Authors: Wang Feijun , Frankowski Kevin J. 
Published: June 2024

AbstractNumerous appropriately substituted pyridyl or phenyl groups serve as a particularly advantageous activation motif for the electrochemical oxidation of amines. Such groups enable a general, mild method for the electrochemical α‐functionalization of tertiary amines across numerous activating groups and amine scaffolds. Notably, the method accommodates an unprecedented range of nucleophile classes, allowing for the introduction of diverse functional groups to the readily prepared amine substrates. The utility of this method is then demonstrated through applications to unsymmetrical bisfunctionalization, site‐selective functionalization of N‐pyridyl amines vs. other activated amines, a formal synthesis of ivosidenib and the diversification of FDA‐approved drugs or natural product substrates.
Controlled Delivery of Paclitaxel via Stable Synthetic Protein Nanoparticles
Authors: Mauser Ava , Waibel Isabel , Banerjee Kaushik , Mujeeb Anzar A. , Gan Jingyao , Lee Sophia , Brown William , Lang Nigel , Gregory Jason , Raymond Jeffery , Franzeb Matthias , Schwendeman Anna , Castro Maria G. , Lahann Joerg 
Published: June 2024

AbstractDespite decades of intense research, glioma remains a disease for which no adequate clinical treatment exists. Given the ongoing therapeutic failures of conventional treatment approaches, nanomedicine may offer alternative options because it can increase the bioavailability of drugs and alter their pharmacokinetics. Here, a new type of synthetic protein nanoparticles (SPNPs) is reported that allow for effective loading and controlled release of the potent cancer drug, paclitaxel (PTX) – a drug that so far has been unsuccessful in glioma treatment due to hydrophobicity, low solubility, and associated delivery challenges. SPNPs are prepared by electrohydrodynamic (EHD) jetting of dilute solutions of PTX‐loaded albumin made by high‐pressure homogenization. After EHD jetting, PTX SPNPs possess a dry diameter of 165 ± 44 nm, hydrated diameter of 297 ± 102 nm, and a zeta potential of −19 ± 8 mV in water. For the SPNP formulation with a total PTX loading of 9.4%, the loading efficiency is 94%, and controlled release of PTX is observed over two weeks (6% burst release). PTX SPNPs are more potent (68% lethality) than free PTX (45% lethality using 0.2% dimethyl sulfoxide). PTX SPNPs in combination with IR show a significant survival benefit in glioma‐bearing mouse models, avoid adverse liver toxicity, and maintain a normal brain architecture. Immunohistochemistry reveals a dramatic tumor size reduction including 40% long‐term survivors without discernible signs of tumor. Using flexibly engineered SPNPs, this work outlines an efficient strategy for the delivery of hydrophobic drugs that are otherwise notoriously hard to deliver.
Near‐Complete Suppression of NIR‐II Luminescence Quenching in Halide Double Perovskites for Surface Functionalization Through Facet Engineering
Authors: Duan Qiudong , Xu Yusheng , Zha Yu , Meng Fanju , Wang Qi , Wen Yugeng , Qiu Jianbei 
Published: June 2024

AbstractLanthanide‐based NIR‐II‐emitting materials (1000–1700 nm) show promise for optoelectronic devices, phototherapy, and bioimaging. However, one major bottleneck to prevent their widespread use lies in low quantum efficiencies, which are significantly constrained by various quenching effects. Here, a highly oriented (222) facet is achieved via facet engineering for Cs2NaErCl6 double perovskites, enabling near‐complete suppression of NIR‐II luminescence quenching. The optimally (222)‐oriented Cs2Ag0.10Na0.90ErCl6 microcrystals emit Er3+ 1540 nm light with unprecedented high quantum efficiencies of 90 ± 6% under 379 nm UV excitation (ultralarge Stokes shift >1000 nm), and a record near‐unity quantum yield of 98.6% is also obtained for (222)‐based Cs2NaYb0.40Er0.60Cl6 microcrystallites under 980 nm excitation. With combined experimental and theoretical studies, the underlying mechanism of facet‐dependent Er3+ 1540 nm emissions is revealed, which can contribute to surface asymmetry‐induced breakdown of parity‐forbidden transition and suppression of undesired non‐radiative processes. Further, the role of surface quenching is reexamined by molecular dynamics based on two facets, highlighting the drastic two‐phonon coupling effect of a hydroxyl group to 4I13/2 level of Er3+. Surface‐functionalized facets will provide new insights for tunable luminescence in double perovskites, and open up a new avenue for developing highly efficient NIR‐II emitters toward broad applications.
Iridium Single Atoms to Nanoparticles: Nurturing the Local Synergy with Cobalt‐Oxide Supported Palladium Nanoparticles for Oxygen Reduction Reaction
Authors: Bhalothia Dinesh , Yan Che , Hiraoka Nozomu , Ishii Hirofumi , Liao Yen‑Fa , Dai Sheng , Chen Po‐Chun , Chen Tsan‐Yao 
Published: June 2024

AbstractA ternary catalyst comprising Iridium (Ir) single‐atoms (SA)s decorated on the Co‐oxide supported palladium (Pd) nanoparticles (denoted as CPI‐SA) is developed in this work. The CPI‐SA with 1 wt.% of Ir exhibits unprecedented high mass activity (MA) of 7173 and 770 mA mgIr−1, respectively, at 0.85 and 0.90 V versus RHE in alkaline ORR (0.1 m KOH), outperforming the commercial Johnson Matthey Pt catalyst (J.M.‐Pt/C; 20 wt.% Pt) by 107‐folds. More importantly, the high structural reliability of the Ir single‐atoms endows the CPI‐SA with outstanding durability, where it shows progressively increasing MA of 13 342 and 1372 mA mgIr−1, respectively, at 0.85 and 0.90 V versus RHE up to 69 000 cycles (3 months) in the accelerated degradation test (ADT). Evidence from the in situ partial fluorescence yield X‐ray absorption spectroscopy (PFY‐XAS) and the electrochemical analysis indicate that the Ir single‐atoms and adjacent Pd domains synergistically promote the O2 splitting and subsequent desorption of hydroxide ions (OH−), respectively. Whereas the Co‐atoms underneath serve as electron injectors to boost the ORR activity of the Ir single‐atoms. Besides, a progressive and sharp drop in the ORR performance is observed when Ir‐clusters and Ir nanoparticles are decorated on the Co‐oxide‐supported Pd nanoparticles.
Cabazitaxel‐Loaded Thermosensitive Hydrogel System for Suppressed Orthotopic Colorectal Cancer and Liver Metastasis
Authors: Chen Yu , Dai Liqun , Shi Kun , Pan Meng , Yuan Liping , Qian Zhiyong 
Published: June 2024

AbstractThe treatment of colorectal cancer is always a major challenge in the field of cancer research. The number of estimated new cases of colorectal cancer worldwide in 2020 is 1 148 515, and the estimated number of deaths is 576 858, revealing that mortality accounted for approximately half of the disease incidence. The development of new drugs and strategies for colorectal cancer treatment is urgently needed. Thermosensitive injectable hydrogel PDLLA‐PEG‐PDLLA (PLEL) loaded with cabazitaxel (CTX) is used to explore its anti‐tumor effect on mice with orthotopic colorectal cancer. CTX/PLEL is characterized by a solution state at room temperature and a hydrogel state at physiologic temperature. The excipients MPEG‐PCL and PDLLA‐PEG‐PDLLA have good biocompatibility and biodegradability. The simple material synthesis and preparation process renders this system cost‐effective and more conducive to clinical transformation. An orthotopic colorectal cancer model is established by transplantation subcutaneous tumors onto the cecum of mice. According to the results of experiments in vivo, CTX/PLEL significantly inhibits orthotopic colorectal cancer and liver metastasis in mice. The results indicate that CTX/PLEL nanoparticle preparations have high security and excellent anti‐tumor effects, and have great application potential in colorectal cancer therapy.
3D Printing of Customizable Transient Bioelectronics and Sensors
Authors: Fumeaux Nicolas , Briand Danick 
Published: June 2024

AbstractTransient electronics have emerged as a new category of devices that can degrade after their functional lifetime, offering tremendous potential as disposable sensors, actuators, wearables, and implants. Additive manufacturing methods represent a promising approach for patterning transient materials, yet examples of fully printed bioelectronic devices are scarce. This study introduces a fully digital 3D printing approach enabling the prototyping and customization of soft bioelectronics made of transient materials. The direct ink writing of poly(octamethylene maleate (anhydride) citrate) (POMaC) as an elastomeric matrix and of a shellac‐carbon ink as a conductor is investigated. Precise and repeatable deposition of both structural and conductive features is achieved by optimizing printing parameters, i.e., the dispense gap, printing speed, and inlet pressure. Multi‐material 3D printing enables the fabrication of functional transient devices. Notably, pressure and strain sensors are shown to operate in ranges relevant to implanted biomechanical monitoring. 3D‐printed transient electrodes are demonstrated to be comparable to state‐of‐the‐art devices in terms of impedance behavior. Finally, physical degradation of the materials is confirmed at physiological conditions. These fully digital additive manufacturing processes enable the monolithic fabrication of customizable transient bioelectronics with adaptable functions and geometries.