bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complications with Computer‐Aided Designed/Computer‐Assisted Manufactured Titanium and Soldered Gold Bars for Mandibular Implant‐Overdentures: Short‐Term Observations
Authors: Katsoulis Joannis , Wälchli Julia , Kobel Simone , Gholami Hadi , Mericske‐Stern Regina 
Published: August 2013

AbstractBackgroundImplant‐overdentures supported by rigid bars provide stability in the edentulous atrophic mandible. However, fractures of solder joints and matrices, and loosening of screws and matrices were observed with soldered gold bars (G‐bars). Computer‐aided designed/computer‐assisted manufactured (CAD/CAM) titanium bars (Ti‐bars) may reduce technical complications due to enhanced material quality.PurposeTo compare prosthetic‐technical maintenance service of mandibular implant‐overdentures supported by CAD/CAM Ti‐bar and soldered G‐bar.Materials and MethodsEdentulous patients were consecutively admitted for implant‐prosthodontic treatment with a maxillary complete denture and a mandibular implant‐overdenture connected to a rigid G‐bar or Ti‐bar. Maintenance service and problems with the implant‐retention device complex and the prosthesis were recorded during minimally 3–4 years. Annual peri‐implant crestal bone level changes (ΔBIC) were radiographically assessed.ResultsData of 213 edentulous patients (mean age 68 ± 10 years), who had received a total of 477 tapered implants, were available. Ti‐bar and G‐bar comprised 101 and 112 patients with 231 and 246 implants, respectively. Ti‐bar mostly exhibited distal bar extensions (96%) compared to 34% of G‐bar (p < .001). Fracture rate of bars extensions (4.7% vs 14.8%, p < .001) and matrices (1% vs 13%, p < .001) was lower for Ti‐bar. Matrices activation was required 2.4× less often in Ti‐bar. ΔBIC remained stable for both groups.ConclusionsImplant overdentures supported by soldered gold bars or milled CAD/CAM Ti‐bars are a successful treatment modality but require regular maintenance service. These short‐term observations support the hypothesis that CAD/CAM Ti‐bars reduce technical complications. Fracture location indicated that the titanium thickness around the screw‐access hole should be increased.
Effect of Age on Single Implant Submersion Rate in the Central Maxillary Incisor Region: A Long‐Term Retrospective Study
Authors: Schwartz‐Arad Devorah , Bichacho Nitzan 
Published: August 2013

AbstractBackgroundIt is contraindicated to place dental implants before growth and development are completed as they are at a risk of submersion due to growth arrest, creating a potential aesthetic problem.PurposeThe present study evaluated the effect of age on mean submersion rate of single dental implant in the central maxillary incisor area as compared with the adjacent natural tooth in implants placed after growth has ceased.Materials and MethodsA retrospective study was conducted on 35 patients (mean age 29.3 ± 9.9 years, 21 females) who received a single dental implant replacing a missing maxillary central incisor from 1992 to 2008 with a follow‐up of at least 3 years. Clinical photos from last follow‐up were digitally analyzed to measure the vertical change between the incisal edge of the implant supported crown and the adjacent natural central incisor.ResultsIn the younger age group (≤30 years), the submersion rate was more than three times higher than in the older age group (>30 years), yielding submersion rates of 1.02 and 0.27% per year, respectively.ConclusionsWhereas implant submersion continues throughout adult life, its rate varies with age. It is evident that this phenomenon is much more conspicuous during the second and third decades of life as compared with the fourth and fifth.
Reliable, verifiable and efficient monitoring of biodiversity via metabarcoding
Authors: Ji Yinqiu , Ashton Louise , Pedley Scott M. , Edwards David P. , Tang Yong , Nakamura Akihiro , Kitching Roger , Dolman Paul M. , Woodcock Paul , Edwards Felicity A. , Larsen Trond H. , Hsu Wayne W. , Benedick Suzan , Hamer Keith C. , Wilcove David S. , Bruce Catharine , Wang Xiaoyang , Levi Taal , Lott Martin , Emerson Brent C. , Yu Douglas W. 
Published: August 2013

AbstractTo manage and conserve biodiversity, one must know what is being lost, where, and why, as well as which remedies are likely to be most effective. Metabarcoding technology can characterise the species compositions of mass samples of eukaryotes or of environmental DNA. Here, we validate metabarcoding by testing it against three high‐quality standard data sets that were collected in Malaysia (tropical), China (subtropical) and the United Kingdom (temperate) and that comprised 55,813 arthropod and bird specimens identified to species level with the expenditure of 2,505 person‐hours of taxonomic expertise. The metabarcode and standard data sets exhibit statistically correlated alpha‐ and beta‐diversities, and the two data sets produce similar policy conclusions for two conservation applications: restoration ecology and systematic conservation planning. Compared with standard biodiversity data sets, metabarcoded samples are taxonomically more comprehensive, many times quicker to produce, less reliant on taxonomic expertise and auditable by third parties, which is essential for dispute resolution.
Lymph flow determination in the equine hindlimb: Lymphoscintigraphic function studies
Authors: Gaedke C. , Witt M. , Koene M. , Berens von Rautenfeld D. , Stadler P. 
Published: August 2013

SummaryThe horse frequently shows idiopathic primary lymphoedema or secondary lymphoedema following trauma or infection to its limbs. Lymphoedema develops if the balance between the amount of lymphatic fluid and capacity of lymphatic transport is disturbed. Scintigraphy appears to be the only in vivo technique to evaluate lymphatic transport capacity. The aim of this study was to develop an evaluation technique to determine the lymph flow in the hindlimb of the horse. This technique might show potential to extend the possibilities for investigating disorders of the lymphatic system in equine extremities.
The Efficacy of Systemic Therapy for Internalizing and Other Disorders of Childhood and Adolescence: A Systematic Review of 38 Randomized Trials
Authors: Retzlaff Ruediger , von Sydow Kirsten , Beher Stefan , Haun Markus W. , Schweitzer Jochen 
Published: August 2013

Systemic therapy (ST) is one of the most widely applied psychotherapeutic approaches in the treatment of children and adolescents, yet few systematic reviews exist on the efficacy ofSTwith this age group. Parallel to a similar study on adults, a systematic review was performed to analyze the efficacy ofSTin the treatment of children and adolescents. All randomized or matched controlled trials (RCT) evaluatingSTin any setting with child and adolescent index patients were identified by database searches and cross‐references, as well as in existing meta‐analyses and reviews. Inclusion criteria were: index patient diagnosed with aDSM‐IV orICD‐10 listed psychological disorder, or suffering from other clinically relevant conditions, and trial published byDecember 2011. Studies were analyzed according to their sample, research methodology, interventions applied, and results at end‐of‐treatment and at follow‐up. This article presents findings for internalizing and mixed disorders. Thirty‐eight trials were identified, with 33 showingSTto be efficacious for the treatment of internalizing disorders (including mood disorders, eating disorders, and psychological factors in somatic illness). There is some evidence forSTbeing also efficacious in mixed disorders, anxiety disorders, Asperger disorder, and in cases of child neglect. Results were stable across follow‐up periods of up to 5 years. Trials on the efficacy ofSTfor externalizing disorders are presented in a second article. There is a sound evidence base for the efficacy ofSTas a treatment for internalizing disorders of child and adolescent patients.
Epileptic activities are common in older people with delirium
Authors: Naeije Gilles , Bachir Imane , Gaspard Nicolas , Legros Benjamin , Pepersack Thierry 
Published: August 2013

AimDelirium is responsible for up to 56% of hospital admissions in the elderly. Epilepsy and delirium share most risk factors and are both associated with confusion. The aim of this work was to study whether a link between epileptic activity (EA) and delirium existed, and if this link was relevant.MethodsCharts of patients aged over 65 years admitted for delirium at the emergency room in 2011 were retrospectively reviewed. Risk factors for delirium, past medical history, medications, biological and iconographic work‐up were analyzed. Those characteristics were compared in patients who had electroencephalogram (EEG) with those who had not. Clinical characteristics of patients with EA on EEG were compared with the patients without EA.ResultsA total of 177 charts were analyzed. The only parameters associated with the realization of an EEG were anti‐epileptic drug treatment and subdural hematoma. A total of 56% (98/177) of patients had EEG. A total of 84% of EEG were abnormal. EA were present in 15% of EEG: 12 with interictal epileptiform discharges and three with non‐convulsive status (NCSE). In multivariate analysis, only dehydration and the use of anticholinergic drugs were associated with EA. Outcome showed a trend for longer hospital stay and a higher institutionalization rate for patients with delirium who had EA.ConclusionEA occur in a significant proportion of delirium, and possibly have a role in the prognosis and pathophysiology of this disorder. Almost no anomalies can distinguish a priori patients in delirium who will have EA. EEG should be carried out in all older patients with delirium. Geriatr Gerontol Int 2013; 14: 447–451.
Are parents and professionals making shared decisions about a child's care on presentation of a suspected shunt malfunction: a mixed method study?
Authors: Smith Joanna , Cheater Francine , Bekker Hilary , Chatwin John 
Published: August 2013

AbstractBackgroundShunts, the main treatment for hydrocephalus, are problematic as they frequently malfunction. Identifying shunt malfunction requires parents to recognize its symptoms and health professionals to integrate parents' information about the child's symptoms within the clinical assessment to reach a diagnosis.AimTo investigate parent–professional shared decision making during the diagnosis of suspected shunt malfunction in acute hospital admissions.Design and methodsA mixed method study involving audio recordings of admission consultations, a shared decision making questionnaire and interviews 1‐week post‐consultation, was undertaken. Twenty‐eight family members and fourteen health professionals participated. The interactions were analysed using conversational analysis, framework approach for the interview data and descriptive statistics for questionnaire responses.FindingsBoth parents and professionals focussed on establishing a diagnosis and ruling out shunt malfunction when a child with hydrocephalus was ill. Participants' perceived effective collaboration as central to this task: parents wanted to contribute to the process of diagnosis by providing information about the likely cause of symptoms. Professionals were satisfied with the level of involvement by parents, although parent satisfaction was more variable. The challenge for professionals was to integrate parents' expertise of their child's presenting symptoms within clinical decision making processes.ConclusionIn this context, both parents' and professionals' perceived their interactions to be about problem‐solving, rather than making decisions about treatments. Although the shared decision‐making model can help patients to make better decisions between treatment options, it is unclear how best to support collaboration between professionals and parents to ensure a good problem‐solving process.
Instant‐quality fluorescence in‐situ hybridization as a new tool for HER2 testing in breast cancer: a comparative study
Authors: Franchet Camille , Filleron Thomas , Cayre Anne , Mounié Eveline , Penault‐Llorca Frédérique , Jacquemier Jocelyne , MacGrogan Gaëtan , Arnould Laurent , Lacroix‐Triki Magali 
Published: August 2013

AimsHER2 instant‐quality fluorescence in‐situ hybridization (IQFISH) is a new fluorescence in‐situ hybridization (FISH) assay developed with a non‐toxic buffer that reduces the hybridization time to 1–2 h, enabling a turnaround time of 3 h 30 min from dewax to counting. The aim of this study was to compare assessment of HER2 status using IQFISH and assessment using standard FISH.Methods and resultsWe selected 160 breast cancer samples according to their HER2 status as determined by immunohistochemistry (IHC) in a retrospective multicentre cohort (40 cases in each scoring category, i.e. 0/1+/2+/3+). Each participating site (n = 5) constructed its tissue microarray (TMA) of 32 archival cases and sent it to the central site (site 1). HER2 IHC, HER2 FISH and HER2 IQFISH were performed blindly at site 1. IQFISH provided excellent quality signals without any background staining, thus allowing excellent reading conditions even on TMA. Statistical analysis showed almost perfect agreement between IQFISH and FISH (99.3%, κ = 0.98). The only discordant case was an equivocal one with an HER2/CEP17 ratio near the ASCO/CAP cut‐off.ConclusionsThe highly concordant data support IQFISH as a useful alternative to FISH, allowing reliable assessment of HER2 status. Use of this method could lead to reporting of HER status to the oncologist within a day.
Characterisation of zero‐trans margarine fats produced from camellia seed oil, palm stearin and coconut oil using enzymatic interesterification strategy
Authors: Ruan Xia , Zhu Xue‐Mei , Xiong Hua , Wang Shen‐qi , Bai Chun‐qing , Zhao Qiang 
Published: August 2013

SummaryZero‐trans interesterified fats were produced from camellia seed oil (CSO), palm stearin (PS) and coconut oil (CO) with three weight ratios (CSO/PS/CO, 50:50:10, 40:60:10 and 30:70:10) using Lipozyme TL IM. Results showed that the interesterified products contained palmitic acid (34.28–42.96%), stearic acid (3.96–4.72%), oleic acid (38.73–47.95%), linoleic acid (5.92–6.36%) and total medium‐chain fatty acids (MCFA)s (∑MCFAs, 5.03–5.50%). Compared with physical blends, triacylglycerols of OOO and PPP were decreased and formed new peaks of equivalent carbon number (ECN) 44 in the interesterified products. The product CPC3′ showed a slip melting point of 36.8 °C and a wide plastic range of solid fat content (SFC) (45.8–0.4%) at 20–40 °C. Also, the major β′ form was determined. These data indicated that the zero‐trans interesterified fats would have a potential functionality for margarine fats. Subsequently, the antioxidative stabilities of interesterified products with the addition of α‐tocopherol (α‐TOH) and ascorbyl palmitate (AP) were investigated. The results indicated that AP had a dose‐dependent effect at concentrations of 100, 200 and 400 ppm.
Microbiota signalling through MyD88 is necessary for a systemic neutrophilic inflammatory response
Authors: Karmarkar Dipti , Rock Kenneth L. 
Published: August 2013

SummaryIn the present study, we have found that intestinal flora strongly influence peritoneal neutrophilic inflammatory responses to diverse stimuli, including pathogen‐derived particles like zymosan and sterile irritant particles like crystals. When germ‐free and flora‐deficient (antibiotic‐treated) mice are challenged with zymosan intraperitoneally, neutrophils are markedly impaired in their ability to extravasate from blood into the peritoneum. In contrast, in these animals, neutrophils can extravasate in response to an intraperitoneal injection of the chemokine, macrophage inflammatory protein 2. Neutrophil recruitment upon inflammatory challenge requires stimulation by microbiota through a myeloid differentiation primary response gene (88) (MyD88) ‐dependent pathway. MyD88 signalling is crucial during the development of the immune system but depending upon the ligand it may be dispensable at the time of the actual inflammatory challenge. Furthermore, pre‐treatment of flora‐deficient mice with a purified MyD88‐pathway agonist is sufficient to restore neutrophil migration. In summary, this study provides insight into the role of gut microbiota in influencing acute inflammation at sites outside the gastrointestinal tract.
Medial Ridge Elevation Wedge Trochleoplasty for Medial Patellar Luxation: A Clinical Study in 5 Dogs
Authors: Fujii Koichi , Watanabe Toshifumi , Kobayashi Takayuki , Hayashi Kei 
Published: August 2013

AbstractObjectiveTo develop a surgical technique to elevate the medial trochlear ridge for surgical correction of medial patellar luxation, and to evaluate clinical outcome.Study DesignCase series.AnimalsDogs (n = 5) with Grade 3 medial patellar luxation.MethodsAn asymmetrical wedge was removed from the trochlear groove, rotated 180°, and placed in the recess to create an elevated medial trochlear ridge. Postoperative radiography, CT scan, and subjective evaluation of clinical outcomes were performed.ResultsSurgical procedure and postoperative recovery were uncomplicated. There was no recurrence of spontaneous luxation and subjectively, gait improved in all dogs. Postoperative radiographs and CT images confirmed the elevated medial trochlear ridge, a significantly increased groove depth/patellar thickness ratio (P < .01), and seating of the patella in the trochlear groove.ConclusionElevating the medial trochlear ridge, instead of deepening the groove, can be considered a viable surgical technique to stabilize luxating patellae.
Low‐Cost, Damage‐Free Patterning of Lead Zirconate Titanate Films
Authors: Welsh Aaron J. , Wilke Rudeger H. T. , Hickner Michael A. , Trolier‐McKinstry Susan 
Published: August 2013

The ability to pattern piezoelectric thin films without damage is crucial for the development of microelectromechanical systems. Direct patterning of complex oxides through microcontact printing was explored as an alternative to subtractive patterning. This process utilized an elastomeric stamp to transfer a chemical solution precursor of a piezoelectric material onto a substrate in a desired pattern. Polyurethane‐based stamps improved wetting of polar solutions on the stamp. This allowed for high‐fidelity patterning over multiple stamping cycles. Microcontact printing deposited patterned PbZr0.52Ti0.48O3 layers from 0.1 to 1 μm in thickness. The lateral feature sizes attained varied from 5 to 500 μm. Upon crystallization at 700°C, the features formed phase‐pure perovskite PZT. The printed features had comparable electrical and electromechanical properties to those of continuous PZT films of similar thicknesses. For example, 1 μm thick PZT features had a permittivity of 1050 and a loss tangent of 0.02 at 10 kHz. The remanent polarization was 30 μC/cm2, and the coercive field was 45 kV/cm. The piezoelectric coefficient e31,f was −7 C/m2. These values indicated that the microcontact printing process did not adversely affect the PZT crystallization or properties for the thicknesses explored in this work.
Admixture analysis in relation to pedigree studies of introgression in a minorityBritish cattle breed: theLincolnRed
Authors: Bray T.C. , Hall S.J.G. , Bruford M.W. 
Published: August 2013

SummaryInvestigation of historic population processes using molecular data has been facilitated by the use of approximate Bayesian computation (ABC), which enables the consideration of multiple alternative demographic scenarios. The Lincoln Red cattle breed provides a relatively simple example of two well‐documented admixture events. Using molecular data for this breed, we found thatstructuredid not resolve very low (<5% levels) of introgression, possibly due to sampling limitations. We evaluated the performance of twoABCapproaches (2BADandDIYABC) against those of two earlier methodologies,ADMIXandLEADMIX, by comparing their interpretations with the conclusions drawn from herdbook analysis. TheABCmethods gave credible values for the proportions of theLincolnRed genotype that are attributable toAberdeenAngus andLimousin, although estimates of effective population size and event timing were not realistic. We suggestABCmethods are a valuable supplement to pedigree‐based studies but that the accuracy of admixture determination is likely to diminish with increasing complexity of the admixture scenario.
Conditionality, Communication and Compliance: The Effect of Monitoring on Collective Labour Rights in Candidate Countries
Authors: Kahn‐Nisser Sara 
Published: August 2013

AbstractThis article presents findings of an empirical analysis which show that the level of candidate countries' compliance with the accession conditionality is positively associated with the extent of annual pre‐accession monitoring. Focusing on conditionality and labour rights in 11 post‐communist CEE candidate countries, in the period between 1998 and 2009, the study analyzes the relationship between the extent of annual monitoring and the post‐communist CEE candidate countries' labour rights scores, two years later. A positive, statistically significant association between the two variables is found. The article proposes an explanation of the findings based on discursive institutionalism, and integrates this with the theory of conditionality. According to discursive institutionalism, monitoring supported conditionality through strategic, normative and communicative mechanisms. It strengthened certainty regarding rewards and sanctions, reduced domestic costs of compliance and supported normative convergence.
Hemoglobin A1c values are affected by hemoglobin level and gender in non‐anemic Koreans
Authors: Bae Ji Cheol , Suh Sunghwan , Jin Sang‐Man , Kim Se Won , Hur Kyu Yeon , Kim Jae Hyeon , Min Yong‐Ki , Lee Myung‐Shik , Lee Moon Kyu , Jeon Won Seon , Lee Won Young , Kim Kwang‐Won 
Published: August 2013

AbstractAims/IntroductionTo evaluate whether hemoglobin A1c (HbA1c) levels are affected by hemoglobin level and gender.Materials and MethodsA cross‐sectional analysis was carried out in a sample of 87,284 non‐diabetic Koreans without anemia who participated in comprehensive health check‐ups between January and December 2009 at the Kangbuk Samsung Hospital Total Healthcare Center in Seoul, Korea. We categorized men and women separately according to fasting plasma glucose and hemoglobin level to carry out the analysis.ResultsHbA1c increased steadily with increasing fasting plasma glucose level. Both men and women with lower hemoglobin had significantly higher HbA1c at a given fasting glucose level, and this result was consistent across the fasting glucose quintiles within the non‐diabetic range. Women had a lower mean hemoglobin value compared with men, and women had higher HbA1c levels at a given fasting glucose level consistently across the fasting glucose deciles. There was also a gender‐specific association between age and HbA1c (P < 0.001 for interaction).ConclusionsHbA1c values were affected by hemoglobin level and gender in non‐anemic Koreans. Thus, hemoglobin level and gender should be considered in the diagnosis of diabetes using HbA1c.