bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early initiation of steroid pulse therapy for neuromyelitis optica in an emergency room setting
Authors: Yamada Saya , Oikawa Sayaka , Komatsu Teppei , Hirai Toshiaki , Dohi Kenji , Ogawa Takeki 
Published: August 2015

CaseA 40‐year‐old man presented to the emergency room with visual impairment, dysesthesia of lower legs, and urinary retention. Two days before admission, he was consulted to the neurology department due to bilateral optic neuritis and scheduled the magnetic resonance imaging of spine. However, the urinary retention deteriorated acutely and he came to the emergency room. On arrival, the plain magnetic resonance image of his spine showed diffuse hyperintensity signals of the spinal cord in T2‐weighted images. He was diagnosed with neuromyelitis optica and steroid pulse therapy was initiated.OutcomeWe began treatment immediately in the emergency room, cooperating with the neurology team. After admission, plasmapheresis was added for his fluctuating symptoms. On hospital day 7, he was discharged without complication.ConclusionIt is important to understand the various clinical manifestations of neuromyelitis optica. In emergency settings, immediate steroid therapy is necessary for better outcomes.
Successful treatment of non‐convulsive status epilepticus diagnosed using bedside monitoring by a combination of amplitude‐integrated and two‐channel simplified electroencephalography
Authors: Egawa Satoshi , Hifumi Toru , Kawakita Kenya , Manabe Arisa , Matumura Hikari , Okazaki Tomoya , Hamaya Hideyuki , Shinohara Natuyo , Shishido Hajime , Takano Koshiro , Abe Yuko , Hagiike Masanobu , Kuroda Yasuhiro 
Published: August 2015

CaseA 66‐year‐old man developed disturbed consciousness and right hemiparesis with transient convulsions in the right arm. Bedside monitoring using a combination of amplitude‐integrated electroencephalography and two‐channel simplified electroencephalography revealed intermittent episodes of 1–3 Hz δ waves lasting for approximately 5 min, consistent with non‐convulsive status epilepticus. Fosphenytoin (22.5 mg/kg/day) and levetiracetam (1,000 mg) prevented right arm convulsions but did not restore consciousness. The two‐channel simplified electroencephalography also showed an intermittent periodic δ wave pattern in the Fp1‐C3 channel. Conventional electroencephalography revealed a polymorphic δ activity that was abolished by 2.5 mg diazepam, thus confirming the diagnosis of non‐convulsive status epilepticus.OutcomeThe patient recovered completely with the antiepileptic drug combination.ConclusionImmediate initiation of bedside monitoring using amplitude‐integrated electroencephalography and two‐channel simplified electroencephalography allows early detection of non‐convulsive status epilepticus in patients with disturbed consciousness, which considerably improves the prognosis.
Periodic Mesoporous Organosilica with Molecular‐Scale Ordering Self‐Assembled by Hydrogen Bonds
Authors: Mizoshita Norihiro , Inagaki Shinji 
Published: August 2015

AbstractNanoporous materials with functional frameworks have attracted attention because of their potential for various applications. Silica‐based mesoporous materials generally consist of amorphous frameworks, whereas a molecular‐scale lamellar ordering within the pore wall has been found for periodic mesoporous organosilicas (PMOs) prepared from bridged organosilane precursors. Formation of a “crystal‐like” framework has been expected to significantly change the physical and chemical properties of PMOs. However, until now, there has been no report on other crystal‐like arrangements. Here, we report a new molecular‐scale ordering induced for a PMO. Our strategy is to form pore walls from precursors exhibiting directional H‐bonding interaction. We demonstrate that the H‐bonded organosilica columns are hexagonally packed within the pore walls. We also show that the H‐bonded pore walls can stably accommodate H‐bonding guest molecules, which represents a new method of modifying the PMO framework.
Probing the interaction of caffeic acid with ZnO nanoparticles
Authors: Belay Abebe , Kim Hyung Kook , Hwang Yoon‐Hwae 
Published: August 2015

AbstractThe binding of ZnO nanoparticles (NPs) and caffeic acid (CFA) was investigated using fluorescence quenching, UV/vis absorption spectrscopy, Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM) and dynamic light scattering (DLS) at different temperatures. The study results indicated fluorescence quenching between ZnO NPs and CFA rationalized in terms of a static quenching mechanism or the formation of non‐fluorescent CFA–ZnO. From fluorescence quenching spectral analysis, the binding constant (Ka), number of binding sites (n) and thermodynamic properties were determined. Values of the quenching (KSV) and binding (Ka) constants decrease with increasing temperature and the number of binding sites n = 2. The thermodynamic parameters determined using Van't Hoff equation indicated that binding occurs spontaneously involving the hydrogen bond, and van der Waal's forces played a major role in the reaction of ZnO NPs with CFA. The FTIR, TEM and DLS measurements also indicated differences in the structure, morphology and size of CFA, ZnO NPs and their corresponding CFA–ZnO. Copyright © 2015 John Wiley & Sons, Ltd.
Solid‐phase synthesis of graphene quantum dots from the food additive citric acid under microwave irradiation and their use in live‐cell imaging
Authors: Zhuang Qianfen , Wang Yong , Ni Yongnian 
Published: August 2015

AbstractThe work demonstrated that solid citric acid, one of the most common food additives, can be converted to graphene quantum dots (GQDs) under microwave heating. The as‐prepared GQDs were further characterized by various analytical techniques like transmission electron microscopy, atomic force microscopy, X‐ray diffraction, X–ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, fluorescence and UV‐visible spectroscopy. Cytotoxicity of the GQDs was evaluated using HeLa cells. The result showed that the GQDs almost did not exhibit cytotoxicity at concentrations as high as 1000 µg mL–1. In addition, it was found that the GQDs showed good solubility, excellent photostability, and excitation‐dependent multicolor photoluminescence. Subsequently, the multicolor GQDs were successfully used as a fluorescence light‐up probe for live‐cell imaging. Copyright © 2015 John Wiley & Sons, Ltd.
Salvage surgery after failure of endoscopic balloon dilatation versus surgery first for ileocolonic anastomotic stricture due to recurrent Crohn's disease
Authors: Li Y , Stocchi L , Shen B , Liu X , Remzi F H 
Published: August 2015

Abstract

Background
Both surgical resection and endoscopic balloon dilatation are treatment options for ileocolonic anastomotic stricture caused by recurrent Crohn's disease unresponsive to medications. Perioperative outcomes of salvage surgery owing to failed endoscopic balloon dilatation in comparison with performing surgery first for the same indication are unclear.

Methods
An analysis of a prospectively maintained Crohn's disease database was carried out to compare perioperative outcomes of patients who had surgery for failure of endoscopic balloon dilatation with outcomes in patients who underwent resection first for ileocolonic anastomotic stricture caused by recurrent Crohn's disease between 1997 and 2013.

Results
Of 194 patients, 114 (58·8 per cent) underwent surgery without previous endoscopic balloon dilatation. The remaining 80 patients had salvage surgery after one or more endoscopic balloon dilatations during a median treatment span of 14·5 months. Patients in the salvage surgery group had a significantly shorter length of anastomotic stricture (P &lt; 0·001). Salvage surgery was associated with increased rates of stoma formation (P = 0·030), overall surgical-site infection (SSI) (P = 0·025) and organ/space SSI (P = 0·030). In multivariable analysis, preoperative endoscopic balloon dilatation was independently associated with both postoperative SSI (odds ratio 3·16, 95 per cent c.i. 1·01 to 9·84; P = 0·048) and stoma diversion (odds ratio 3·33, 1·14 to 9·78; P = 0·028).

Conclusion
Salvage surgery after failure of endoscopic balloon dilatation is associated with increased adverse outcomes in comparison with surgery first. This should be discussed with patients being considered for endoscopic balloon dilatation for ileocolonic anastomotic stricture due to recurrent Crohn's disease.
Arsenic trioxide rewires mantle cell lymphoma response to bortezomib
Authors: Zhao Ling‐Ling , Liu Yuan‐Fang , Peng Li‐Jun , Fei Ai‐Mei , Cui Wen , Miao Sheng‐Chao , Hermine Olivier , Gressin Remy , Khochbin Saadi , Chen Sai‐Juan , Wang Jin , Mi Jian‐Qing 
Published: August 2015

AbstractAlthough most of the mantle cell lymphoma (MCL) patients initially responded well to bortezomib (BTZ), the dose‐dependent toxicities have greatly limited the application of BTZ to MCL. To investigate the efficacy and mechanism of arsenic trioxide (ATO) with BTZ in inducing apoptosis of MCL cells, two MCL cell lines, along with primary cells from MCL patients (n = 4), were used. Additionally, the NOD‐SCID mice xenograft model of Jeko‐1 cells was established to study the anti‐MCL mechanisms in an in vivo setting. ATO treatment highly improved BTZ capacity to inhibit proliferation and induce apoptosis of MCL cells. Furthermore, the interaction of Noxa and Mcl‐1 leads Bak to release from Mcl‐1 or from Bcl‐xl, which could further activate Bak and Bax and then induce cell apoptosis. We also found that when lower doses of BTZ were used in combination with ATO, more effective proapoptotic effects in both the cell lines and the primary cells were obtained compared to the effects of BTZ used alone at higher doses. Simultaneously, the combination of these two drugs delayed the tumor growth in mice more effectively than BTZ alone. The cooperative anti‐MCL effects of this combination therapy both in vitro and in vivo strongly provided a new strategy to the clinical treatment of MCL.
A role for the dehydrogenase DHRS7 (SDR34C1) in prostate cancer
Authors: Seibert Julia K. , Quagliata Luca , Quintavalle Cristina , Hammond Thomas G. , Terracciano Luigi , Odermatt Alex 
Published: August 2015

AbstractSeveral microarray studies of prostate cancer (PCa) samples have suggested altered expression of the “orphan” enzyme short‐chain dehydrogenase/reductase DHRS7 (retSDR4, SDR34C1). However, the role of DHRS7 in PCa is largely unknown and the impact of DHRS7 modulation on cancer cell properties has not yet been studied. Here, we investigated DHRS7 expression in normal human prostate and PCa tissue samples at different tumor grade using tissue microarray and immunovisualization. Moreover, we characterized the effects of siRNA‐mediated DHRS7 knockdown on the properties of three distinct human prostate cell lines. We found that DHRS7 protein expression decreases alongside tumor grade, as judged by the Gleason level, in PCa tissue samples. The siRNA‐mediated knockdown of DHRS7 expression in the human PCa cell lines LNCaP, BPH1, and PC3 significantly increased cell proliferation in LNCaP cells as well as cell migration in all of the investigated cell lines. Furthermore, cell adhesion was decreased upon DHRS7 knockdown in all three cell lines. To begin to understand the mechanisms underlying the effects of DHRS7 depletion, we performed a microarray study with samples from LNCaP cells treated with DHRS7‐specific siRNA. Several genes involved in cell proliferation and adhesion pathways were found to be altered in DHRS7‐depleted LNCaP cells. Additionally, genes of the BRCA1/2 pathway and the epithelial to mesenchymal transition regulator E‐cadherin were altered following DHRS7 knockdown. Based on these results, further research is needed to evaluate the potential role of DHRS7 as a tumor suppressor and whether its loss‐of‐function promotes PCa progression and metastasis.
Young People's Perspectives on Participatory Ethics: Agency, Power and Impact in Domestic Abuse Research and Policy‐Making
Authors: Houghton Claire 
Published: August 2015

Children's perspectives literature repositions children and young people as active participants in surviving domestic abuse, protecting their family, opposing the violence and recovering from abuse. However, key tenets of safeguarding in relation to domestic abuse, both in practice and childhood research ethics, struggle to fully recognise children's agency and the need to empower children and young people as well as women. Children's right to participation now extends to national policy‐making in many countries, yet has not been explored in relation to the interdependency of women and children's rights, safety and wellbeing where both have been subject to abuse.This paper challenges the current exclusion of young voices from the development of ethical praxis. It outlines a participatory ethical approach that promotes the inclusion and empowerment of young survivors in research and policy. Young expert advisors on Scottish domestic abuse policy (2009–11) co‐develop the approach (participatory action research) which is informed by a wider study (2004–11) about children's help‐seeking and solutions for practice. Mullenderet al.'saccepted model of three Cs and Ds (consent, confidentiality, child protection: danger, distress, disclosure) are adapted to focus on children's agency. Three Es are added focusing on children's power and impact: enjoyment, empowerment and emancipation. Copyright © 2015 John Wiley & Sons, Ltd.‘This paper challenges the current exclusion of young voices from the development of ethical praxis’Key Practitioner MessagesChildren and young people have a distinct, essential voice in risk assessment and management.They are competent and central decision‐makers, they can consent to participation.Participation can be a powerful therapeutic tool.Enjoyment, empowerment and emancipation are intrinsic to participation, alongside recognition of children's agency in safeguarding.Access to power, equal voice and impact on children's lives are preconditions of participation to young survivors – to be worth the inherent risk of speaking out.‘Participation can be a powerful therapeutic tool’‘Access to power, equal voice and impact on children's lives are preconditions of participation to young survivors’
Eroded, Lost or Reconstructed? Security in Finnish Children's Experiences of Post‐Separation Stalking
Authors: Nikupeteri Anna , Tervonen Harriet , Laitinen Merja 
Published: August 2015

The paper analyses children's experiences of (in)security in cases of post‐separation stalking and asks how children can be safeguarded under such circumstances. Children are at particular risk when the family is stalked by the biological father or stepfather. This qualitative study draws on data collected from 13 children using three different methods: therapeutically‐oriented group sessions, interviews with the children and a series of ten mother and child therapy sessions. Supplementing these data are insights gained from interviews with 18 women/mothers, the main targets of the stalking. The analysis of the narratives distinguishes three overlapping forms of security – eroded, lost and reconstructed – in which the degree of trust and extent of knowledge are the main elements. Children feel insecurity to different degrees and experiences of (in)security may vary even from child to child in the same family. The findings highlight the crucial importance of considering a child's relationship to his or her mother, siblings and trusted adults when intervening in stalking. Loved ones, day care and school staff, and social welfare workers have a significant role to play in reconstructing and strengthening children's security. The study suggests that this can be done through ‘safety talk’ with a mother and her children. Copyright © 2015 John Wiley & Sons, Ltd.‘Children are at particular risk when the family is stalked by their biological father or stepfather’Key Practitioner Messages

In cases of post‐separation stalking of the family, children's security can appear in three forms: eroded, lost and reconstructed.
Feelings of insecurity vary and can appear to differing degrees within the same family.
It is important in safeguarding children to lighten the burden that they take upon themselves of reconstructing security for themselves and their loved ones.
Practitioners can play a significant role by providing space for and facilitating ‘safety talk’ between children and their mothers.
‘Children's security can appear in three forms: eroded, lost and reconstructed’
N‐Methylpyrrolidone Hydroperoxide/Cs2CO3 as an Excellent Reagent System for the Hydroxy‐Directed Diastereoselective Epoxidation of Electron‐Deficient Olefins
Authors: Victor Napoleon John , Gana Janardhanan , Muraleedharan Kannoth Manheri 
Published: August 2015

AbstractThis report introduces N‐methylpyrrolidone hydroperoxide (NMPOOH)/base as an excellent reagent system for hydroxy‐directed syn selective epoxidation of electron‐deficient olefins, characterized by high diastereoselectivity, short reaction times and remarkable chemoselectivity, especially in presence of oxidatively labile nitrogen or sulfur atoms. NMPOOH also proves efficient in the oxidation of electron‐deficient aromatic aldehydes, in the removal of oxazolidinone chiral auxiliary, and in the functionalization of alkenes and alkynes, showing wide application potential.
Development of a Rhodium(II)‐Catalyzed Chemoselective C(sp3)H Oxygenation
Authors: Lin Yun , Zhu Lei , Lan Yu , Rao Yu 
Published: August 2015

AbstractWe report the first example of RhII‐catalyzed chemoselective double C(sp3)H oxygenation, which can directly transform various toluene derivatives into highly valuable aromatic aldehydes with great chemoselectivity and practicality. The critical combination of catalyst Rh(OAc)2, oxidant Selectfluor, and solvents of TFA/TFAA promises the successful delivery of the oxidation with satisfactory yields. A possible mechanism involving a unique carbene–Rh complex is proposed, and has been supported by both experiments and theoretical calculations.
A Comparison of the Stability and Reactivity of Diamido‐ and Diaminocarbene Copper Alkoxide and Hydride Complexes
Authors: Collins Lee R. , Riddlestone Ian M. , Mahon Mary F. , Whittlesey Michael K. 
Published: August 2015

AbstractThe mononuclear N‐heterocyclic carbene (NHC) copper alkoxide complexes [(6‐NHC)CuOtBu] (6‐NHC=6‐MesDAC (1), 6‐Mes (2)) have been prepared by addition of the free carbenes to the tetrameric tert‐butoxide precursor [Cu(OtBu)]4, or by protonolysis of [(6‐NHC)CuMes] (6‐NHC=6‐MesDAC (3), 6‐Mes (4)) with tBuOH. In contrast to the relatively stable diaminocarbene complex 2, the diamidocarbene derivative 1 proved susceptible to both thermal and hydrolytic ring‐opening reactions, the latter affording [(6‐MesDAC)Cu(OC(O)CMe2C(O)N(H)Mes)(CNMes)] (6). The intermediacy of [(6‐MesDAC)Cu(OH)] in this reaction was supported by the generation of Cu2O as an additional product. Attempts to generate an isolable copper hydride complex of the type [(6‐MesDAC)CuH] by reaction of 1 with Et3SiH resulted instead in migratory insertion to generate [(6‐MesDAC‐H)Cu(P(p‐tolyl)3)] (9) upon trapping by P(p‐tolyl)3. Migratory insertion was also observed during attempts to prepare [(6‐Mes)CuH], with [(6‐Mes‐H)Cu(6‐Mes)] (10) isolated, following a reaction that was significantly slower than in the 6‐MesDAC case. The longer lifetime of [(6‐Mes)CuH] allowed it to be trapped stoichiometrically by alkyne, and also employed in the catalytic semi‐reduction of alkynes and hydrosilylation of ketones.
Benzylic Functionalization of Anthrones via the Asymmetric Ring Opening of Oxabicycles Utilizing a Fourth‐Generation Rhodium Catalytic System
Authors: Loh Charles C. J. , Fang Xiang , Peters Brendan , Lautens Mark 
Published: August 2015

AbstractWhile anthrones exist as privileged scaffolds in bioactive molecules, the enantioselective functionalization of anthrones is surprisingly scarce in the literature, with no asymmetric transition metal catalyzed example to date. Herein, we report the first asymmetric transition metal catalyzed benzylic functionalization of anthrones through the rhodium(I) catalyzed desymmetrization of oxabicycles. As previously developed rhodium(I) systems were found to be unsuitable for this substrate, a new robust fourth‐generation [Rh(cod)OH]2 based catalytic system was developed to address synthetic challenges in this protocol.
Formal Total Synthesis of (+)‐Cortistatins A and J
Authors: Kuang Liping , Liu Lok Lok , Chiu Pauline 
Published: August 2015

AbstractAn efficient formal total synthesis of (+) cortistatins A and J has been accomplished, by exploiting a highly diastereoselective intramolecular [4+3] cycloaddition of epoxy enolsilanes as the key reaction to construct rings B and C of the cortistatins in one step.
ChemInform Abstract: Double Salt Crystal Structure of Nonasodium Dihydrogen Nonavanadoplatinate(IV) Trihydrogen Nonavanadoplatinate(IV) Tetracontahydrate: Stepwise‐Protonated Nonavanadoplatinate(IV).
Authors: Joo Hea‐Chung , Park Ki‐Min , Lee Uk 
Published: August 2015

AbstractNa9[H2PtV9O28] [H3PtV9O28]·40H2O is obtained by a hydrothermal reaction at pH 2 according to the literature.
ChemInform Abstract: Synthesis of Chiral β‐Aminomalonates from 2‐Chlorotetrafluoroethanesulfinyl Aldimines Through the Mannich Reaction.
Authors: Yang Kai , Jiang Min , Liu Jin‐Tao 
Published: August 2015

AbstractThe Mannich reaction of aldimines (I) with malonate (II) proceeds with high diastereoselectivity to form β‐aminomalonates (III).
ChemInform Abstract: Asymmetric Michael Addition Reactions of Nitroalkanes to 2‐Furanones Catalyzed by Bifunctional Thiourea Catalysts.
Authors: Bai Zhushuang , Ji Ling , Ge Zemei , Wang Xin , Li Runtao 
Published: August 2015

AbstractHighly functionalized γ‐lactones with two or three consecutive stereogenic carbons are synthesized with diastereoselectivities up to <20:1 dr and enantioselectivities up to <99% e.e.
ChemInform Abstract: Catalyst‐Controlled exo/endo Selectivity in a Post‐Ugi Intramolecular Hydroarylation: Synthesis of Pyrrolopyridinones, Pyrroloazepinones, and Benzothienopyridines.
Authors: Li Zhenghua , Kumar Amit , Sharma Sunil K. , Parmar Virinder S. , Van der Eycken Erik V. 
Published: August 2015

AbstractThe InCl3‐catalyzed cyclization of Ugi adducts (V) leads to pyrrolopyridinones (VI).
ChemInform Abstract: Regioselective Ring Opening of Styrene Oxide Catalyzed by MoO2(acac)2.
Authors: Yang Hongwei , Xu Liming , Luo Cuicui , Lu Chunxu , Cheng Guangbin 
Published: August 2015

AbstractEfficient and regioselective ring opening of styrene oxide with various N‐, O‐, and C‐nucleophiles is achieved using MoO2(acac)2 as catalyst.
ChemInform Abstract: Versatile and Chemoselective Transformation of Aliphatic and Aromatic Secondary Amides to Nitriles.
Authors: Geng Hui , Huang Pei‐Qiang 
Published: August 2015

AbstractDehydration of secondary amides by a combination of triflic anhydride and 2‐fluoropyridine leads to nitriles under mild reaction conditions while tolerating various functional groups.
ChemInform Abstract: Palladium‐Catalyzed C—H Functionalization of Acyldiazomethane and Tandem Cross‐Coupling Reactions.
Authors: Wang Zhi‐Xiang , et al.  
Published: August 2015

AbstractThe oxidative Pd‐catalyzed C—H coupling of a variety of acyldiazomethanes with alkenyl and aryl iodides and bromides is reported.
ChemInform Abstract: Cu‐Catalyzed Debrominative Cyanation of gem‐Dibromoolefins: A Facile Access to α,β‐Unsaturated Nitriles.
Authors: Ahuja Brij Bhushan , Sudalai Arumugam 
Published: August 2015

AbstractAn efficient conversion of gem‐dibromoolefins to α,β‐unsaturated nitriles is achieved by a copper catalyzed reductive cyanation with NaCN.
ChemInform Abstract: Nickel‐Catalyzed Regio‐ and Enantioselective Aminolysis of 3,4‐Epoxy Alcohols.
Authors: Wang Chuan , Yamamoto Hisashi 
Published: August 2015

AbstractThe regioselective aminolysis of 3,4‐epoxyalcohols using Ni‐perchlorate as catalyst is developed.