bluuebunny/crossref_metadata_2025_split huggingface dataset:
RNA-RNA interaction prediction using genetic algorithm
Authors: Montaseri Soheila , Zare-Mirakabad Fatemeh , Moghadam-Charkari Nasrollah 
Published: June 2014

Abstract

Background
RNA-RNA interaction plays an important role in the regulation of gene expression and cell development. In this process, an RNA molecule prohibits the translation of another RNA molecule by establishing stable interactions with it. In the RNA-RNA interaction prediction problem, two RNA sequences are given as inputs and the goal is to find the optimal secondary structure of two RNAs and between them. Some different algorithms have been proposed to predict RNA-RNA interaction structure. However, most of them suffer from high computational time.

Results
In this paper, we introduce a novel genetic algorithm called GRNAs to predict the RNA-RNA interaction. The proposed algorithm is performed on some standard datasets with appropriate accuracy and lower time complexity in comparison to the other state-of-the-art algorithms. In the proposed algorithm, each individual is a secondary structure of two interacting RNAs. The minimum free energy is considered as a fitness function for each individual. In each generation, the algorithm is converged to find the optimal secondary structure (minimum free energy structure) of two interacting RNAs by using crossover and mutation operations.

Conclusions
This algorithm is properly employed for joint secondary structure prediction. The results achieved on a set of known interacting RNA pairs are compared with the other related algorithms and the effectiveness and validity of the proposed algorithm have been demonstrated. It has been shown that time complexity of the algorithm in each iteration is as efficient as the other approaches.
Proletarian Sensibilities: The Body Politics of New Tendency Literature (1924–27)
Authors: Chung Kimberly 
Published: June 2014

Abstract
This article examines the New Tendency movement spearheaded by the artist organization KAPF (Korean Artist Proletarian Federation) that represented the beginning of “proletarian sensibility” in 1920s colonial Korea. Influenced by the convergence of literary criticism and the importation of Marxism, proletarian sensibility is a network that threads through a fabric of images, film, and affective narrative representations about the abject conditions of the masses. New Tendency literature—with its development of tropes of excess, sensational language, descriptions of poverty, and the image of the body-in-pain—exhibits the complex development of collective politics through the embodied experience of the abject subject.
Recurrence of Non–Small Cell Lung Cancer With Visceral Pleural Invasion
Authors: Altorki Nasser , Wang Xiaofei , Damman Bryce , Jones David R. , Wigle Dennis , Port Jeffrey , Conti Massimo , Ashrafi Ahmad S. , Liberman Moishe , Landreneau Rodney , Yasufuku Kazuhiro , Yang Stephen , Mitchell John D. , Keenan Robert , Bauer Thomas , Miller Daniel , Kozono David , Mentlick Jennifer , Vokes Everett , Stinchcombe Thomas E. 
Published: August 2024

ImportanceThe randomized clinical trial Cancer and Leukemia Group B (CALGB) 140503 showed that for patients with clinically staged T1N0 non–small cell lung cancer (NSCLC; ≤2 cm), sublobar resections were associated with similar oncological outcomes to those after lobar resection. The association of the extent of parenchymal resection with recurrence and survival in patients with tumors pathologically upstaged to T2 based on visceral pleural invasion (VPI) is controversial.ObjectiveTo determine survival and recurrence rates in patients with small peripheral pT2 NSCLC (≤2 cm) that was treated by either lobar or sublobar resection in CALGB 140503.Design, Participants, and SettingCALGB 140503, a randomized multicenter noninferiority trial, included 697 patients with small peripheral NSCLC that was clinically staged as T1N0. Enrollment was from June 2007 through March 2017 at 83 participating institutions, and after a median follow-up of 7 years, the primary outcome of disease-free survival after sublobar resection was noninferior to that after lobar resection.InterventionLobar or sublobar resection.Main Outcomes and MeasuresSurvival end points were estimated by the Kaplan-Meier estimator. Hazard ratios and 95% CIs were estimated using stratified Cox proportional hazard models.ResultsOf 679 participants, 390 (57.4%) were female, and the median (range) age was 67.8 (37.8-89.7) years. Among 697 patients randomized, 566 (81.2%) had pT1 tumors (no VPI) and 113 (16.2%) had pT2 tumors (VPI). Five-year disease-free survival was 65.9% (95% CI, 61.9%-70.2%) in patients with pT1 compared with 53.3% (95% CI, 44.3%-64.1%) in patients with pT2 tumors (stratified log-rank: P = .02). Disease recurrence developed in 27.6% of patients with pT1 (locoregional only: 60 [10.8%]; distant only: 81 [14.6%]) and 41.6% of those with pT2 (locoregional only: 17 [15.0%]; distant only: 27 [23.9%]). Five-year recurrence-free survival was 73.1% (95% CI, 69.2%-77.1%) for pT1 tumors and 58.2% (95% CI, 49.2%-68.8%) for pT2 tumors (stratified log-rank: P = .01). There were no intergroup differences in disease-free or recurrence-free survival based on the extent of parenchymal resection.Conclusions and RelevanceThe results of this secondary analysis suggest that compared with patients with tumors without VPI, patients who had tumors with VPI had worse disease-free and recurrence-free survival and a higher rate of local and distant disease recurrence. These high rates of recurrence were independent of the extent of parenchymal resection, and these data support the inclusion of these patients in adjuvant therapy trials.Trial RegistrationClinicalTrials.gov Identifier: NCT0049933
Association Between Achievement of Clinical Disease Control and Improvement in Patient‐Reported Outcomes and Quality of Life in Patients With Psoriatic Arthritis in the Phase 3 SELECT‐PsA 1 and 2 Randomized Controlled Trials
Authors: Kavanaugh Arthur , Mease Philip , Gossec Laure , Ranza Roberto , Tsuji Shigeyoshi , Douglas Kevin , Lane Michael , Lippe Ralph , Mittal Manish , Gao Tianming , Setty Arathi , Ciecinski Sandra , Aletaha Daniel , Nash Peter 
Published: August 2024

ObjectiveWe explored the relationship between achievement of clinical disease control and improvements in and normative values for patient‐reported outcomes (PROs), including quality of life (QoL) measures, in patients with psoriatic arthritis (PsA).MethodsThis was a post hoc analysis of 104‐week data from the SELECT‐PsA 1 and 2 trials in adults with PsA and inadequate response to one or more conventional synthetic (SELECT‐PsA 1) or biologic (SELECT‐PsA 2) disease‐modifying antirheumatic drug. Patients were initially randomized to upadacitinib 15 mg once daily (QD) to placebo switched to upadacitinib 15 mg QD at week 24 or to adalimumab 40 mg every other week (SELECT‐PsA 1 only), and data were pooled across treatments and analyzed. We evaluated several clinical disease control measures (minimal disease activity [MDA]; very low disease activity [VLDA]; and low disease activity [LDA] and/or remission by Disease Activity in Psoriatic Arthritis [DAPSA], Psoriatic Arthritis Disease Activity Score [PASDAS], and Routine Assessment of Patient Index Data 3 [RAPID3]) and examined their associations with improvements and normative values for various PROs.ResultsA total of 1,069 and 317 patients were analyzed for SELECT‐PsA 1 and 2, respectively. In both studies, responders (patients who achieved MDA or VLDA, and DAPSA, PASDAS, and RAPID3 LDA or remission) at week 104 achieved more marked changes from baseline, and more responders achieved normative values in PROs compared with nonresponders (most nominal P < 0.0001). Furthermore, numerically larger proportions of responders achieved minimal clinically important differences across PROs compared with nonresponders in both studies. In addition, patients who achieved MDA or VLDA were more likely to achieve DAPSA, PASDAS, and RAPID3 LDA or remission (all nominal P < 0.0001) for upadacitinib 15 mg QD and when treatment arms were pooled.ConclusionPatients with PsA who achieve clinical disease control are more likely to achieve improvements and normative values in PROs and QoL measures, which reinforces disease control as a treatment target.
Rational Design of Engineered Bionic Periosteum for Dynamic Immunoinduction, Smart Bactericidal, and Efficient Bone Regeneration
Authors: Yu Lei , Qiao Yusen , Ge Gaoran , Chen Miao , Yang Peng , Li Wenhao , Qin Yi , Xia Wenyu , Zhu Chen , Pan Guoqing , Zhang Po , Yang Huilin , Wang Chen , Bai Jiaxiang , Geng Dechun 
Published: August 2024

AbstractBone defects arising from trauma and tumors present a potential risk of infection and compromise host immune function. Within a dysfunctional microenvironment, the uncontrolled breeding of bacteria and persistent chronic inflammation exacerbate bone loss, impeding bone regeneration and repair. Macrophages function as specialized phagocytes within the immune microenvironment and the orchestrated role of distinct phenotypes during regeneration has attracted significant attention. The M1 phenotype exhibits antimicrobial activities to eliminate bacterial threats, while the M2 phenotype secretes anti‐inflammatory mediators to fine‐tune the immune microenvironment. Here, a biphasic delivery system consisting of a photothermal agent (graphene oxide, GO) coated and an immune modulator (urolithin A, UA) encapsulated in coaxial electrospun nanofibers with a dynamic regulation function of macrophage behavior is designed. It is observed that the GO coating exhibited remarkable photothermal performance within the near‐infrared window, affecting the phagocytic activity of macrophage subsets in an integrin‐RhoA‐ROCK1 dependent manner. The sustained release of UA from the core layer induced a phenotypic switch by downregulating TNF signaling and upregulating TGF signaling. This system also demonstrated a promotion of bone regeneration in vivo. Overall, this strategy achieved sequential regulation of macrophage phenotypes, effectively preventing infection and fostering bone tissue regeneration.
An Ultrahydrating Polymer that Protects Protein Therapeutics and RNA‐Lipid Nanoparticles Against Freezing, Heat and Lyophilization Stress
Authors: Herrmann Anna , Abbina Srinivas , Bathula Nuthan Vikas , Nouri Peyman Malek Mohammadi , Chafeeva Irina , Constantinescu Iren , Abbasi Emaan , Abbasi Usama , Drayton Matthew , Luo Haiming Daniel , Moon Haisle , Gill Arshdeep , Xi Yu , Bertram Allan K. , Du Caigan , Haag Rainer , Blakney Anna K. , Kizhakkedathu Jayachandran N. 
Published: August 2024

AbstractRNA and protein‐based therapeutics constitute almost half of recent drug approvals and receive considerable attention within biotechnology industries. Ensuring their stability and longevity in the context of heat, freezing, and lyophilization processes are paramount to a successful deployment. However, the advancement of formulations designed to achieve this goal is still in its nascent phase. To address these challenges, a new class of semi‐dendritic hydrophilic polymer with extended linear units is reported, which showcase very high hydration. These novel polymers demonstrated exceptional efficacy in preserving messenger RNA‐ (mRNA‐) and self‐amplifying RNA‐ (saRNA‐) lipid nanoparticles during freezing and lyophilization. Additionally, they have been found to protect therapeutic proteins against external stressors such as freezing, heat, and lyophilization. These polymers are non‐toxic, which enables their utilization at high concentrations and eliminates the requirement for removal prior to administration. It is found that their unique topology contributes to the high hydration. These excipients are anticipated to create new prospects in biotechnology, food science, and cryopreservation.
Multiresponsive Ionic Conductive Alginate/Gelatin Organohydrogels with Tunable Functions
Authors: Tordi Pietro , Tamayo Adrián , Jeong Yeonsu , Bonini Massimo , Samorì Paolo 
Published: August 2024

AbstractMaterials combining stretchability and sensitivity to external stimuli are key for wearable electronics applications to enable the emergence of disruptive technologies in biosensing, health monitoring, photodetection and human motion recognition. Conductive organohydrogels have gained significant attention due to their high sensitivity and cost‐effective preparation. Biopolymers like gelatin and alginate offer unique opportunities for developing responsive wearable devices, owing to their biocompatibility and sensitivity toward environmental factors. Here sustainable bio‐inspired method is presented to produce alginategelatin organohydrogels combining transparency in the visible range, ionic conductivity, high stretchability, and multiresponsiveness. The controlled alginate's crosslinking with various metal cations like Mn2+, Cu2+, Fe3+, and Zr4+ enables modulating ionic conductivity as well as finely tuning the material's thermal and mechanical properties. These organohydrogels show responsiveness to temperature (from 10 to 50 degrees, with a sensitivity of 0.19 K−1), relative humidity (from 20 to 80%, with a sensitivity of 0.022 RH(%)−1), and strain (gauge factor >1.6), enabling real‐time monitoring of environmental and physiological parameters. Remarkably, they also exhibit photoresponsivity of 9.2 µA W−1 under visible light, a feature rarely reported in literature. The ease of tuning responsiveness to the chosen stimuli and the high sensitivities open perspectives for applying these materials as wearable stretchable sensors.
A historical syndemic? The impact of synergistic epidemics of measles and scarlet fever on life expectancy in Victoria, Australia (1860s–1870s)
Authors: Battles Heather T. , Roberts Phillip M. 
Published: August 2024

AbstractObjectivesTo explore whether synergistic epidemics of measles and scarlet fever in 1860s–1870s Victoria, Australia could be characterized as syndemics, we apply the methods of Sawchuk, Tripp, and Samakaroon (Social Science & Medicine 2022, 295, 112956) to quantify the impact of each of the two major co‐occurring epidemic events (1867, 1875) in terms of life expectancy (LE) changes. Sawchuk et al. posit the presence of a harvesting effect, indicated by a statistically significant increase in LE in the immediate post‐epidemic “fallow period”, as a criterion for identification of a historical syndemic. We test an alternate hypothesis that the same methods can identify a short‐term scarring effect.Materials and MethodsUsing annual age‐ and cause‐specific death statistics and census population data, we constructed abridged period life tables for baseline period, potential syndemic year, and “fallow” year for each of the two periods (1860s and 1870s). We compared LE at birth using Z‐tests. We decomposed age‐cause‐specific mortality according to Arriaga's method to identify age—and cause‐specific contributions to LE change.ResultsLE was significantly lower than baseline (1864–1865) in 1867 but not in the “fallow” year (1869). LE in 1875 and the 1878 “fallow” year were both significantly below baseline (1871–1873). Age‐cause‐specific decomposition showed similar patterns for 1867 and 1875 for measles and scarlet fever combined effects.DiscussionEvidence of a scarring effect following the 1875 measles/scarlet fever combined peak supports the interpretation of this event as a syndemic. We suggest the short‐term scarring effect can be a useful additional criterion for identifying historical syndemics.
Characterization of white matter hyperintensities in Down syndrome
Authors: Morcillo‐Nieto Alejandra O. , Zsadanyi Sara E. , Arriola‐Infante Jose E. , Carmona‐Iragui Maria , Montal Victor , Pegueroles Jordi , Aranha Mateus Rozalem , Vaqué‐Alcázar Lídia , Padilla Concepción , Benejam Bessy , Videla Laura , Barroeta Isabel , Fernandez Susana , Altuna Miren , Giménez Sandra , González‐Ortiz Sofía , Bargalló Núria , Ribas Laia , Arranz Javier , Torres Soraya , Iulita Maria Florencia , Belbin Olivia , Camacho Valle , Alcolea Daniel , Lleó Alberto , Fortea Juan , Bejanin Alexandre 
Published: August 2024

AbstractINTRODUCTIONIn Down syndrome (DS), white matter hyperintensities (WMHs) are highly prevalent, yet their topography and association with sociodemographic data and Alzheimer's disease (AD) biomarkers remain largely unexplored.METHODSIn 261 DS adults and 131 euploid controls, fluid‐attenuated inversion recovery magnetic resonance imaging scans were segmented and WMHs were extracted in concentric white matter layers and lobar regions. We tested associations with AD clinical stages, sociodemographic data, cerebrospinal fluid (CSF) AD biomarkers, and gray matter (GM) volume.RESULTSIn DS, total WMHs arose at age 43 and showed stronger associations with age than in controls. WMH volume increased along the AD continuum, particularly in periventricular regions, and frontal, parietal, and occipital lobes. Associations were found with CSF biomarkers and temporo‐parietal GM volumes.DISCUSSIONWMHs increase 10 years before AD symptom onset in DS and are closely linked with AD biomarkers and neurodegeneration. This suggests a direct connection to AD pathophysiology, independent of vascular risks.Highlights
White matter hyperintensities (WMHs) increased 10 years before Alzheimer's disease symptom onset in Down syndrome (DS).
WMHs were strongly associated in DS with the neurofilament light chain biomarker.
WMHs were more associated in DS with gray matter volume in parieto‐temporal areas.
MOFite: A High‐Density Lithiophilic and Scalable Metal–Organic Framework Anode for Rechargeable Lithium‐Ion Battery
Authors: Gaber Safa , Mohammed Abdul Khayum , Javaregowda Bharathkumar H. , Martínez José Ignacio , Sánchez Pilar Pena , Gándara Felipe , Krishnamoorthy Kothandam , Shetty Dinesh 
Published: August 2024

AbstractDeveloping an anode material that has better performance efficiency than commercial graphite while keeping the features of economic scalability and environmental safety is highly desirable yet challenging. MOFs are a promising addition to the ongoing efforts, however, the relatively poor performance, chemical instability, and large‐scale economic production of efficiency‐proven pristine MOFs restrict their utility in real‐life energy storage applications. Furthermore, hierarchical porosity for lucid mass diffusion, high‐density lithiophilic sites are some of the structural parameters for improving the electrode performance. Herein, we have demonstrated the potential of economically scalable salicylaldehydate 3D‐conjugated‐MOF (Fe−Tp) as a high‐performance anode in Li‐ion batteries: the anode‐specific capacity achieved up to 1447 mAh g−1 at 0.1 A g−1 and 89 % of cyclic stability after 500 cycles at 1.0 A g−1 for pristine MOF. More importantly, incorporating 10 % Fe−Tp doping in commercial graphite (MOFite) significantly enhanced lithium storage, doubling capacity after 400 cycles. It signifies the potential practical utility of Fe−Tp as a performance booster for commercial anode material.
Asymmetric Total Synthesis of Euphordraculoate A and Pedrolide
Authors: Tu Canhui , Yang Yunlong , Jiang Yuzhi , Hao Yan , Wang Zhen , Fu Shaomin , Qin Song , Liu Bo 
Published: August 2024

AbstractHere we report the asymmetric total syntheses of two rearranged tigliane diterpenoids, euphordraculoate A and pedrolide. A reductive dihydroxylation cascade and Nazarov cyclization were performed to generate euphordraculoate A, which was subjected to a cascade of Eu‐promoted dienyl enolization, intramolecular Diels–Alder reaction and enol‐ketone tautomerization to afford pedrolide, a pathway consistent with our proposal for the biogenesis of pedrolide.
Piezo‐catalysis Mechanism Elucidation by Tracking Oxygen Reduction to Hydrogen Peroxide with In situ EPR Spectroscopy
Authors: He Jie , Li Zhi , Feng Pengju , Lu Gang , Ding Tengda , Chen Li , Duan Xiaoguang , Zhu Mingshan 
Published: August 2024

AbstractFor piezoelectric catalysis, the catalytic mechanism is a topic of great controversy, with debates centered around whether it belongs to the energy band theory or the screening charge effect which are similar to mechanisms of photocatalysis and electrochemical catalysis, respectively. Due to the formation of different intermediate active‐species during two‐electron oxygen reduction reaction (ORR) via electro‐ and photo‐catalysis, the key to solving this problem is precisely monitoring the active species involved in ORR during electro‐, photo‐, and piezo‐catalysis under identical condition. Here, a semiconductor material, BiOBr with abundant oxygen vacancies (BOB‐OV) was found remarkable catalytic activity in H2O2 production by all three catalytic methods. By employing in situ electron paramagnetic resonance (EPR) spectroscopy, the H2O2 evolution pathway through piezo‐catalysis over BOB‐OV was monitored, which showed a similar reaction pathway to that observed in photo‐catalytic process. This finding represents solid evidence supporting the notion that piezo‐catalytic mechanism of ORR is more inclined towards photo‐catalysis rather than electro‐catalysis. Significantly, this exploratory conclusion provides insight to deepen our understanding of piezo‐catalysis.
Artificial Polymerizations in Living Organisms for Biomedical Applications
Authors: Chen Yun , Tan Brynne Shu Ni , Cheng Yu , Zhao Yanli 
Published: August 2024

AbstractWithin living organisms, numerous nanomachines are constantly involved in complex polymerization processes, generating a diverse array of biomacromolecules for maintaining biological activities. Transporting artificial polymerizations from lab settings into biological contexts has expanded opportunities for understanding and managing biological events, creating novel cellular compartments, and introducing new functionalities. This review summarizes the recent advancements in artificial polymerizations, including those responding to external stimuli, internal environmental factors, and those that polymerize spontaneously. More importantly, the cutting‐edge biomedical application scenarios of artificial polymerization, notably in safeguarding cells, modulating biological events, improving diagnostic performance, and facilitating therapeutic efficacy are highlighted. Finally, this review outlines the key challenges and technological obstacles that remain for polymerizations in biological organisms, as well as offers insights into potential directions for advancing their practical applications and clinical trials.
Aldehyde End‐Capped Degradable Polyethylenes From Hydrogen‐Controlled Ethylene/CO Copolymerization
Authors: Song Chuang , Yang Dian , Wang Chaoqun , Tang Zhenxin , Long Yingyun , Zhang Yuxing , Jian Zhongbao 
Published: August 2024

AbstractTo access degradable polyolefin plastic, non‐alternating copolymerization of ethylene (E) and carbon monoxide (CO) for producing polyethylene (PE) with in‐chain ketones is particularly appealing; however, it still presents significant challenges such as molecular weight modulation (hydrogen response) and chain endgroup control (functional terminal). In this study, we achieved hydrogen‐controlled E/CO non‐alternating copolymerization using late transition metal catalysts. This process results in linear PEs containing the desired non‐alternating in‐chain keto groups (1.0–9.3 mol %) and with tunable molecular weights ranging from 43 to 195 kDa. In this reaction, H2 serves as a chain transfer agent, modulating the polymer's molecular weight, forming unique aldehyde endgroups and eliminating usual olefinic endgroups; CO undergoes non‐alternating insertion into the PE chain, resulting in a strictly non‐alternating structure (>99 %) for the keto‐PE. The dispersed incorporation of in‐chain keto groups retains bulk properties of PE and makes PE susceptible to photodegradation, which produces significantly lower molecular weight polymers and oligomers with unambiguous vinyl and acetyl terminals.