bluuebunny/crossref_metadata_2025_split huggingface dataset:
Romance in Games: What It Is, How It Is, and How Developers Can Improve It
Authors: McDonald Heidi 
Published: July 2015

Abstract
This project extends my first “Romance in Games” survey, seeking to be of assistance to developers who produce romance content in their games, resulting in richer gaming experiences for a wider audience. I have sought information about market readiness for LGBT romance content in games, how the audience defines “romance games,” what people’s definition of “satisfying game romance” is and how well developers are living up to that definition, as well as what developers can do to make game romance more satisfying for players. This survey consisted of four sections: basic demographics, general gaming preferences, the nature of romance in games, and satisfaction with romance in games. The preliminary findings are that straight audiences are ready for—and queer audiences crave—more LGBT romance content in single-player role-playing games (RPGs); that BioWare warrants and deserves a prominent position in any critical discussion of romance in single-player RPGs; and that there are tangible reasons why customers might not find game romances satisfying, although these problems are reparable. The end suggestion, recognizing that there is much more to be gleaned from this data set, is that wider research be conducted about these matters with proper funding and staffing by researchers.
Protecting the 'Na Plachtě' natural monument from development. A case study on the importance of public participation in environmental protection (English version)
Authors: Záhumenská Vendula 
Published: July 2015

Na Plachtě is located at the south-eastern edge of Hradec Králové where over the past 20 years conflicts of interests between environmentalists and local developers have arisen concerning the development and commercial use of the site. This case study is concerned with the importance of public participation in environmental issues and describes the specific opportunities for influencing environmental decision-making. The author refers to specific events which eventually resulted in the declaration of the Na Plachtě site as a “natural monument”; she also investigates opportunities for changing the landscape plan which would strengthen protection against any construction on the site. Other possibilities for influencing decision-making about issues of concern to the general public and which have an impact on the work of regional representatives are also discussed.
Tumor-induced osteomalacia due to a recurrent mesenchymal tumor overexpressing several growth factor receptors
Authors: Yavropoulou Maria P , Gerothanasi Nikolina , Frydas Athanasios , Triantafyllou Evangelia , Poulios Chris , Hytiroglou Prodromos , Apostolou Panagiotis , Papasotiriou Ioannis , Tournis Symeon , Kesisoglou Isaak , Yovos John G 
Published: July 2015

Summary
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused primarily by benign mesenchymal tumors. These tumors typically follow a benign clinical course and local recurrence occurs in <5% of cases. We investigated a 49-year-old man with a recurrent mesenchymal phosphaturic tumor showing no signs of malignancy. The patient suffered from chronic muscle weakness, myalgia and cramps. His medical record included the diagnosis of oncogenic osteomalacia, for which he was submitted to tumor resection in the left leg three times before. Laboratory examination showed hypophosphatemia, hyperphosphaturia and an elevated serum FGF23 level. A radical surgical approach (amputation) was advised, however, complete biochemical and clinical remission was not reached. Molecular analysis of the tumor cells demonstrated overexpression of growth factor receptors implicated in tumor angiogenesis and metastatic potential (platelet derived growth factor type A (PDGFRA), PDGFRB and vascular endothelial growth factor receptor) together with increased expression of FGF23, x-linked-phosphate-regulating endopeptidase and KLOTHO. TIO is usually associated with benign phosphauturic tumors and, when identified, resection of the tumor leads to complete remission in the majority of cases. The underlying pathophysiology of recurrences in these tumors is not known. This is the first report showing increased expression of growth factor receptors in a locally aggressive but histopathologically benign phosphaturic mesenchymal tumor.

Learning points

TIO is usually associated with benign soft tissue or bone neoplasms of mesenchymal origin.

These tumors typically follow a benign clinical course and even in the rare malignant cases local recurrence occurs in <5%.

Successful identification and removal of the tumor leads to full recovery in the majority of cases.
How Well Do Molecular and Pedigree Relatedness Correspond, in Populations with Diverse Mating Systems, and Various Types and Quantities of Molecular and Demographic Data?
Authors: Kopps Anna M , Kang Jungkoo , Sherwin William B , Palsbøll Per J 
Published: July 2015

AbstractKinship analyses are important pillars of ecological and conservation genetic studies with potentially far-reaching implications. There is a need for power analyses that address a range of possible relationships. Nevertheless, such analyses are rarely applied, and studies that use genetic-data-based-kinship inference often ignore the influence of intrinsic population characteristics. We investigated 11 questions regarding the correct classification rate of dyads to relatedness categories (relatedness category assignments; RCA) using an individual-based model with realistic life history parameters. We investigated the effects of the number of genetic markers; marker type (microsatellite, single nucleotide polymorphism SNP, or both); minor allele frequency; typing error; mating system; and the number of overlapping generations under different demographic conditions. We found that (i) an increasing number of genetic markers increased the correct classification rate of the RCA so that up to &gt;80% first cousins can be correctly assigned; (ii) the minimum number of genetic markers required for assignments with 80 and 95% correct classifications differed between relatedness categories, mating systems, and the number of overlapping generations; (iii) the correct classification rate was improved by adding additional relatedness categories and age and mitochondrial DNA data; and (iv) a combination of microsatellite and single-nucleotide polymorphism data increased the correct classification rate if &lt;800 SNP loci were available. This study shows how intrinsic population characteristics, such as mating system and the number of overlapping generations, life history traits, and genetic marker characteristics, can influence the correct classification rate of an RCA study. Therefore, species-specific power analyses are essential for empirical studies.
EDITORIAL
Authors: Massal Julie 
Published: July 2015

<p>El presente dossier es el resultado de una convocatoria lanzada a inicios de 2014, por el grupo de Relaciones internacionales del IEPRI y el equipo de la Revista. El dossier que se presenta en esta edición propone una reflexión sobre la situación actual en la que se encuentran las relaciones internacionales de y en América Latina, particularmente en el área andina. Los artículos recibidos se inscriben en su gran mayoría en tres ejes de reflexión propuestos en la convocatoria: 1) el reto energético; 2) los procesos de integración regional e internacional; 3) los cambios políticos internos.</p>
POLÍTICA EXTRACCIONISTA DE HIDROCARBUROS EN COLOMBIA Y ECUADOR: CRÍTICA DESDE EL ANÁLISIS DEL POSDESARROLLO
Authors: Bonilla Montenegro Julián Darío 
Published: July 2015

<p>En la región andino-amazónica se concentran gran cantidad de las reservas de hidrocarburos que han sido explotados por gobiernos que se adscriben a distintas corrientes ideológicas, tanto en aspectos políticos como económicos. Sin embargo, una de las falencias que se presenta alrededor de la ortodoxia tradicional para el diseño de las políticas económicas es la de construir parámetros que midan el crecimiento económico como una variable esencial para el desarrollo económico; esto por encima de factores de protección ambiental o de respeto a comunidad originarias de las regiones. En el caso particular de Colombia y Ecuador, el proceso se ha construido sobre la necesidad de generar procesos extraccionistas en zonas medioambientales protegidas. Lo anterior puede criticarse desde los estudios del posdesarrollo, tomando en consideración un parámetro metodológico de carácter comparativo; también recurriendo a la información coyuntural extraída a través de las redes virtuales que responden a este proceso; e igualmente, haciendo énfasis en las características particulares que se presentan en cada uno de estos países, bajo la necesidad de considerar la explotación económica como la única alternativa para el crecimiento y el desarrollo económico.</p>
A Keyboard-Based r-Shaped Triboelectric Generator for Active Noise-Free Recording
Authors: Han Mengdi , Meng Bo , Cheng Xiaoliang , Zhu Fuyun , Shi Mayue , Zhang Haixia 
Published: July 2015

ABSTRACTThis paper presents a method for noise-free recording of the keyboard-based musical instruments. By integrating an r-shaped triboelectric generator (TEG) into the keyboard of a piano, it can produce electric signal while playing music due to the combination of contact electrification and electric induction. We investigated the electric signal and developed a graphical user interface to convert the electric signal back to music. Using the piano and the graphical user interface, active noise-free recording can be realized. Namely, only the sound produced by the piano can be converted and recorded, while other noise in the environment can be filtered automatically.
Multicultural Music Therapy: An Exploration
Authors: Mahoney Emily Rose 
Published: July 2015

This paper examines multicultural issues that currently exist within the field of music therapy. Music therapists often find themselves working with clients who come from very different cultural backgrounds than themselves. Before music therapists can understand and work with clients from other cultures, they must first have an understanding of their own background and culture, and how their values and beliefs have shaped them as therapists. This paper highlights the value of multicultural awareness, and explores issues of disability, gender/sexuality, feminism, and race, as they relate to music therapy.
Gene‐Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network‐Based Microarray Analysis
Authors: Guzeldemir‐Akcakanat Esra , Sunnetci‐Akkoyunlu Deniz , Orucguney Begum , Cine Naci , Kan Bahadır , Yılmaz Elif Büsra , Gümüşlü Esen , Savli Hakan 
Published: July 2015

Background: In this study, molecular biomarkers that play a role in the development of generalized aggressive periodontitis (GAgP) are investigated using gingival tissue samples through omics‐based whole‐genome transcriptomics while using healthy individuals as background controls.Methods: Gingival tissue biopsies from 23 patients with GAgP and 25 healthy individuals were analyzed using gene‐expression microarrays with network and pathway analyses to identify gene‐expression patterns. To substantiate the results of the microarray studies, real‐time quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) was performed to assess the messenger RNA (mRNA) expression of MZB1 and DSC1. The microarrays and qRT‐PCR resulted in similar gene‐expression changes, confirming the reliability of the microarray results at the mRNA level.Results: As a result of the gene‐expression microarray studies, four significant gene networks were identified. The most upregulated genes were found as MZB1, TNFRSF17, PNOC, FCRL5, LAX1, BMS1P20, IGLL5, MMP7, SPAG4, and MEI1; the most downregulated genes were found as LOR, LAMB4, AADACL2, MAPT, ARG1, NPR3, AADAC, DSC1, LRRC4, and CHP2.Conclusions: Functions of the identified genes that were involved in gene networks were cellular development, cell growth and proliferation, cellular movement, cell–cell signaling and interaction, humoral immune response, protein synthesis, cell death and survival, cell population and organization, organismal injury and abnormalities, molecular transport, and small‐molecule biochemistry. The data suggest new networks that have important functions as humoral immune response and organismal injury/abnormalities. Future analyses may facilitate proteomic profiling analyses to identify gene‐expression patterns related to clinical outcome.
Response to Drought Stress in Sainfoin: Within and Among Ecotype Variation
Authors: Irani Sayareh , Majidi Mohammad Mahdi , Mirlohi Aghafakhr , Karami Mostafa , Zargar Mahnaz 
Published: July 2015

ABSTRACTEcotypes of sainfoin (Onobrychis viciifolia Scop.) have not been extensively studied, and knowledge about their variation is generally limited. In the present study, 100 sainfoin genotypes from 10 ecotypes were clonally propagated and evaluated under water‐stressed and nonstressed conditions for 2 yr. Among‐ and within‐ecotype variation plus heritability of agronomic, morphological, and physiological traits were estimated and the associations of traits were determined. For most of the measured traits among‐ and within‐ecotype effects were significant. The variance within ecotypes was at least four times higher for most of the measured traits when compared with variance among ecotypes. The within‐ecotype contribution was 67 to 71% for dry matter yield (DMY), 69% for number of stems per plant, and 69 to 91% for morphological traits. Large within‐ecotype variation for DMY and yield‐related traits could express yield stability across environments and maximize genetic progress per breeding cycle. The lowest heritability estimates were obtained for DMY and leaf‐to‐stem ratio, and the highest one was estimated for antioxidant activity and chlorophyll content. Water stress caused significant decrease in all measured traits except for carotenoid content, proline content, catalase, ascorbate peroxidase, and superoxide dismutase activity. Genotypic differences for water‐stress tolerance identified in this study were mainly attributed to the ability of tolerant ecotypes to accumulate a greater amount of proline in their leaves in response to water stress. Dry matter yield had positive correlations with plant height, inflorescence length, number of stems per plant, and proline content under both moisture environments. On the basis of factor analysis, the first three factors in both environments were considered as “forage yield components,” “photosynthetic pigments,” and “antioxidant activity.” High within‐ecotype variation indicated the importance of selection within populations for suitable parental materials in sainfoin breeding. Baft was the best ecotype under both moisture environments in this respect.
Foreign Protein Detection in Transgenic Rice Revealed by Comparative Proteomic Analysis
Authors: Yang Yanhua , Dai Li , Zhu Keming , Xia Hengchuan , Chen Liang , Liu Hailong , Chen Keping 
Published: July 2015

ABSTRACTTo investigate whether the foreign protein in transgenic rice (Oryza sativa L.) can be detected and then characterize the different proteins between transgenic rice and nontransgenic rice, we employed proteomic tools including two‐dimensional electrophoresis (2‐DE) and mass spectrometry (MS) to globally identify different proteins between Bt‐‘Minghui 63’ (MH63) (with the fused Cry1Ab–Cry1Ac gene) and its nontransgenic control MH63. In all, 37 statistically different proteins between Bt‐MH63 and MH63 were successfully identified, including six unique proteins in Bt‐MH63. Gene ontology analysis showed that these six unique proteins were mainly involved in metabolic, catalytic, binding, and antioxidant process. Among these six unique proteins, two non‐rice source proteins, phosphinothricin‐N‐acetyltransferase, were only expressed in germinating seed and seedling of Bt‐MH63, but not in MH63, which were further confirmed by matrix‐assisted laser desorption–ionization time of flight (MALDI‐TOF) MS–MS analysis. Our work suggests that a comparative proteomic approach may be feasible for identifying foreign proteins and genes in rice.
Cross-Border Financing by the Industrial Sector Increases Competition in the Domestic Banking Sector
Authors: Jayaraman Sudarshan , Kothari S. P. 
Published: July 2015

ABSTRACT
We predict that access to cross-border financing by the industrial sector reduces firms' reliance on domestic banks, thereby leading to lower rents for banks and greater competition in the domestic banking sector. We also predict that banks take on more risk to offset these lost rents and remain competitive. Using mandatory adoption of International Financial Reporting Standards (IFRS) to identify variation in cross-border financing, we find evidence consistent with our hypotheses. Additional tests verify that the effects emanate from the demand side (i.e., firms not relying on banks) rather than the supply side (i.e., banks not willing to lend to firms). Overall, we document how competition from overseas financial markets influences the domestic banking sector.
Corporate Accountability Reporting and High-Profile Misconduct
Authors: Christensen Dane M. 
Published: July 2015

ABSTRACT
I investigate whether corporate accountability reporting helps protect firm value. Specifically, I examine (1) whether corporate accountability reporting helps firms prevent the occurrence of high-profile misconduct (e.g., bribery, kickbacks, discrimination), and (2) whether prior corporate accountability reporting reduces the negative stock price reaction when high-profile misconduct does occur. Using multiple methods to address self-selection, I find that, on average, firms that report on their corporate accountability activities are less likely to engage in high-profile misconduct, consistent with the reporting process helping firms to manage their operations better. Additionally, I find that when high-profile misconduct does occur, firms that have previously issued corporate accountability reports experience a less negative stock price reaction, consistent with corporate accountability reports influencing perceptions of managerial intent, which, in turn, influences expected punishments.
Putative precipitating factors for hepatic encephalopathy in dogs: 118 cases (1991–2014)
Authors: Lidbury Jonathan A. , Ivanek Renata , Suchodolski Jan S. , Steiner Jörg M. 
Published: July 2015

Abstract
Objective—To elucidate the relationship between plasma ammonia concentration and severity of hepatic encephalopathy and determine whether factors that precipitate hepatic encephalopathy in humans are associated with the presence of clinical signs of hepatic encephalopathy in dogs previously treated for the disease.
Design—Retrospective case series.
Animals—118 dogs with hepatic encephalopathy.
Procedures—The medical records database of a veterinary teaching hospital was searched for records of dogs in which hepatic encephalopathy was diagnosed between October 1, 1991, and September 1, 2014. Hepatic encephalopathy severity was graded on a 5-point scale, and the correlation between disease severity and plasma ammonia concentration was determined. Respective associations between hepatic encephalopathy and systemic inflammatory response syndrome, gastrointestinal hemorrhage, dietary indiscretion, constipation, furosemide treatment, azotemia, hypokalemia, hyponatremia, alkalosis, and hyperammonemia were assessed by Fisher exact tests followed by multivariable logistic regression.
Results—Severity of hepatic encephalopathy at hospital admission was not significantly correlated with plasma ammonia concentration. Dogs treated for hepatic encephalopathy prior to hospital admission were significantly less likely to have clinical signs of the disease at hospital admission, compared with dogs that were not treated for the disease (OR, 0.36; 95% confidence interval, 0.17 to 0.78). None of the putative precipitating factors for hepatic encephalopathy were significantly associated with the presence of clinical signs of the disease at hospital admission.
Conclusions and Clinical Relevance—Results indicated that hepatic encephalopathy treatment alleviated clinical signs of the disease. Further investigation is necessary to identify precipitating factors for hepatic encephalopathy in dogs. (J Am Vet Med Assoc 2015;247:176–183)
Financial expectations of first-year veterinary students
Authors: Lim Christine C. , Schulhofer-Wohl Sam , Root Kustritz Margaret V. , Molgaard Laura K. , Lee David 
Published: July 2015

Abstract
Objective—To assess student awareness of the financial costs of pursuing a veterinary education, to determine student expectations for financial returns of a veterinary career, and to identify associations between student debt and factors such as future career plans or personality type.
Design—Survey.
Sample—First-year veterinary students at the University of Minnesota College of Veterinary Medicine.
Procedures—In 2013, prior to the first day of class, all incoming first-year students received an email invitation to complete an online survey. The survey contained questions about demographics, current financial situation, current debt, expected debt at graduation, expected annual income following graduation, intent to pursue specialty training, and Myers-Briggs personality type.
Results—72 of 102 (71%) students completed the survey; 65 respondents answered all relevant questions and provided usable data. Student responses for expected debt at graduation were comparable to national averages for veterinary college graduates; responses for expected annual income following graduation were lower than averages for University of Minnesota veterinary college graduates and national averages. However, students predicted even lower annual income if they did not attend veterinary college. Expected debt and expected annual income were not correlated with factors such as personality type or future career plans.
Conclusions and Clinical Relevance—Results indicated that first-year veterinary students were aware of the financial costs of their veterinary education and had realistic expectations for future salaries. For typical veterinary students, attending veterinary college appeared to be financially worthwhile, given lower expected earnings otherwise. (J Am Vet Med Assoc 2015;247:196–203)