bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENENTUAN NILAI SPF DARI SEDIAAN KRIM TABIR SURYA EKSTRAK KULIT BAWANG MERAH (Allium cepa L.)
Authors: Seto Deni Gagat , Tutik Tutik , Amalia Putri 
Published: August 2024

Kulit yang terpapar sinar ultraviolet (UV) dalam waktu cukup lama dapat menimbulkan efek negatif seperti fotokarsinogenesis, upaya yang dapat dilakukan untuk melindungi kulit dari paparan sinar UV diantaranya adalah tabir surya yang melindungi serta menjaga kulit agar tetep sehat, salah satu bahan alam yang berpotensi untuk menjadi tabir surya adalah ekstrak kulit bawang merah, indikator yang menjelaskan keefektifan suatu zat yang bersifat UV protector adalah SPF (Sun Protection Factor), semakin tinggi nilai SPF suatu zat aktif maka semakin efektif untuk melindungi kulit. Tujuan penelitian ini untuk mengetahui pengaruh yang lebih efektif dalam formula krim tabir surya ekstrak etanol 96% kulit bawang merah dengan konsentrasi yang berbeda menggunakan metode Spektrofotometri UV-Vis. Berdasarkan hasil penelitian, krim memenuhi semua persyaratan setelah dilakukan berbagai uji kualitas sediaan dan pengukuran nilai SPF dengan factor koreksi (CF) 7,8 yang didapatkan dari sediaan komersial. Memperlihatkan, krim ekstrak kulit bawang merah (Allium cepa L.) dengan kode formulasi K(-), FI, FII, dan FIII konsentrasi 0%, 0,02%, 0,08%, dan 0,14%, dihasilkan nilai SPF berturut-turut 0,6; 2,7; 9,8; dan 18,9. Hal ini menunjukkan penambahan ekstrak kulit bawang merah pada FIII sudah termasuk kategori ultra berdasarkan ketentuan FDA yaitu tidak kurang dari >15.
UJI AKTIVITAS ANTIBAKTERI Escherichia coli EKSTRAK METANOL KULIT BAWANG MERAH (Allium cepa L.) DENGAN METODE EKSTRAKSI REFLUKS
Authors: Putri Diana , Tutik Tutik , Nofita Nofita , Husein Saddam 
Published: August 2024

Diare adalah penyakit yang dapat ditularkan melalui makanan dan minuman yang sebelumnya telah terkontaminasi oleh agen patogen yang dapat menginfeksi usus yang disebabkan oleh bakteri Escherichia coli. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antibakteri serta menentukan konsentrasi ekstrak metanol kulit bawang merah (Allium cepa L.) terhadap bakteri Escherichia coli dengan menggunakan metode ekstraksi refluks. Kulit bawang merah diekstrak dengan menggunakan metode refluks, ekstrak yang telah diperoleh di uji aktivitas antibakteri terhadap bakteri Escherichia coli dengan konsentrasi ekstrak kulit bawang merah yang digunakan adalah 25%, 50%, 75%, dan 100%. Dari hasil ekstraksi diperoleh rendemen sebesar 10,6% dan untuk hasil uji aktivitas antibakteri terhadap bakteri Escherichia coli diperoleh konsentrasi 75% dengan rata-rata zona hambat 2,467 mm dan konsentrasi 100% dengan rata-rata zona hambat 2,767 mm dimana dapat dikategorikan dalam kategori sedang. Analisis data menggunakan one way ANOVA hasil menunjukan adanya perbedaan bermakna antar setiap kelompok perlakuan P>0,05.
UJI AKTIVITAS Staphylococcus aureus DENGAN PEMBERIAN DAYA HAMBAT CUKA KULIT PISANG KEPOK (Musa-Eumusa-ABB)
Authors: Widelia Putri , Dheaputri Ati , Febriyanto Tedy , RS Sunita , Sitompul Linda 
Published: August 2024

Masalah global yang sedang dihadapi pada negara berkembang maupun negara maju, salah satunya adalah efek samping antibiotik. Salah satu penyebab infeksi yaitu bakteri Staphylococcus aureus. Staphylococcus aureus bisa menyebabkan keracunan makanan staphylococcus, bakterimia, endokardititis, osteomeilitis hematogen akut, pneumonia, meningitis, abses yang dapat menyebar keseluruh tubuh. Staphylococcus aureus telah mengalami resistensi terhadap antibiotik. Maka alternatif yang dilakukan adalah dengan cara menggunakan bahan yang berasal dari alam yaitu dengan memanfaatkan produk kulit pisang kapok menjadi olahan cuka kulit pisang kapok (Musa-Eumusa-ABB).Penelitian ini bertujuan Untuk mengetahui uji daya hambat cuka kulit pisang kapok (Musa-Eumusa-ABB) terhadap bakteri Staphycoccus aureus. Penelitian ini merupakan penelitian True eksperiment laboratorium dengan enam perlakuan. Masing-masing perlakuan diulang sebanyak empat kali dengan variasi kosentrasi 100%, 75%, 50 % dan 25% dengan tetrasiklin sebagai kontrol positif serta aquades sebagai kontrol negatif. Analisa data dengan menggunakan analisa Anova Statistika. Rata-rata diameter zona hambat pada konsentrasi 100% sebesar 17.25 mm, konsentrasi 75% sebesar 13.5 mm, konsentrasi 50% sebesar 25% mm dan pada konsentrasi 25% tidak terbentuk zona hambat bakteri. Hasilnya diketahui bahwa cuka kulit pisang kepok memiliki kemampuan menghambat pertumbuhan Staphylococcus aureus terlihat dengan adanya zona bening yang dibentuk disekitar cakram. Semakin besar konsentrasi yang digunakan maka semakin besar tingkat efektivitas cuka kulit pisang kepok sebagai antibakteri Staphylococcus aureus, dengan konsentrasi paling efektif yaitu 100%.
Lumbar osteopathic manipulative treatment can improve KOA symptoms: short-term efficacy observation and mechanism analysis
Authors: Du Peiyu , Li Xi , Yin Shilin , Li Wenyi , Sun Xilong , Zhang Zekun , Zhao Jianyong , Shijun Gao , Du Shuangqing , Zhang Di 
Published: August 2024

BackgroundManipulative treatment can effectively improve knee pain and function, but no previous studies have shown that lumbar osteopathic manipulative treatment can improve knee symptoms. To explore the influence of lumbar manipulation on KOA and analyze its principlerelationship between coronal position of lumbar spine and KOA.MethodsPatients were divided into OMT group and DT group according to treatment. WOMAC scores were compared between the two groups, and X-ray examinations before and after treatment were performed in OMT group to analyze the imaging changes.ResultsBoth OMT group and DT group showed significant improvement in WOMAC score after treatment, and the improvement in OMT group was better than that in DT group. After OMT treatment, cTMI(P = 0.034), mL-SOD (P &lt; 0.001), mΔL-KOD (P = 0.001), LL (P = 0.036), and FTA(P = 0.026) were significantly changed.ConclusionCompared with drug therapy, lumbar manipulation can better improve WOMAC scores in KOA patients. It relives symptoms by loosening muscles and correcting small joint disorders to improve local knee alignment.
Development of flexible shifts in control modes and its relationship with academic achievement
Authors: Verma Tripti , Kar Bhoomika R. 
Published: August 2024

IntroductionChildren transition from engaging control reactively as per the demands of a given situation, to using a proactive mode of control as an automatic response in all situations. Yet, it is crucial to study the age at which this transition takes place and to understand the development of the ability of flexible shifts in modes of control.MethodsTo investigate developmental changes in this ability of children and its relationship with school readiness and academic achievement, children in the continuous age groups of 5, 6–8, and 9–11 years performed a cued switching task. The task conditions were manipulated such that in the case of “Proactive Impossible” condition, only reactive control was available; in the case of “Proactive Encouraged” condition, only proactive control was available; and in the case of “Proactive Possible” condition, both proactive and reactive control could be used.ResultsA clear preference for reactive control was evident in 5-year-old children, along with the ability to engage in proactive control when encouraged. Nine to eleven-year-old children favored proactive control as their default mode. However, 6–8-year-olds displayed flexibility in shifting between control modes, compared to the other two age groups. This ability correlated with school readiness and academic achievement.DiscussionThese findings emphasize that 6–8 years of age marks the developmental period for flexible cognitive control, with the benefits of having access to and utilizing both control modes and their relationship with academic achievement.
In-situ observations of wave- and current-supported fluid mud dynamics on a hyperturbid macrotidal mudflat
Authors: Li Mingliang , Chen Dezhi , Wu Hao , Tang Jieping , Zhang Yiyi , Luo Feng , Gou Fugang , Gong Xulong , Wang Ya Ping 
Published: August 2024

Wave- and current-supported fluid mud on gently sloped continental shelves represents a type of sediment gravity flow capable of rapidly transporting substantial sediment over short periods, significantly contributing to coastal geomorphic evolution. To investigate the dynamics of intertidal fluid mud events, in-situ observations were conducted from May 9 to May 18, 2017, using a seabed tripod system at the lower intertidal flat of the central Jiangsu coast, China. Fluid mud was observed following a medium wind-wave event, with a maximum significant wave height of 0.42 m. The liquefied seabed, loosened by liquefaction, facilitated bed erosion and sediment resuspension. Fluid mud layers, with mean suspended sediment concentrations (SSCs) exceeding 10 g/L, periodically formed during high slack tide, early flood, and late ebb phases. These layers varied in thickness from 4 cm to 20 cm and exhibited strong stratification caused by suspended sediment. Fluid mud disappeared when the bottom turbulence kinetic energy exceeded a threshold of 0.00045 m²/s² due to an increase in current velocity. The downslope movement of intertidal fluid mud was estimated using a theoretical buoyancy-friction model and validated by observed offshore-directed velocity jets at 0.1 m above the seabed during high slack tide phases. Additionally, onshore winds favored fluid mud formation during early flood phases, while offshore winds favored it during late ebb phases. These observations suggest that fluid mud can form on intertidal flats under conditions where tidal flows and winds align, contributing to a deeper understanding of the formation mechanisms of shallow gravity flows and the improvement of sediment transport models.
A longitudinal examination of the effect of physical exercise on the emotional states of college students: exploring the sense of coherence as a mediator through a cross-lagged panel analysis
Authors: Cao Yunxia , Luo Lin 
Published: August 2024

PurposeThis longitudinal study aimed to investigate the causal relationship between physical exercise and emotional states among university students, focusing on the mediating role of sense of coherence.MethodA total of 1,215 university students (aged 18–25 years) were recruited and completed questionnaires assessing physical activity (International Physical Activity Questionnaire-Short Form), emotional states (Positive and Negative Affect Schedule), and sense of coherence (Sense of Coherence Scale-13) at three time points over a three-month period. Preliminary analyses included independent samples t-tests, chi-square tests, and Pearson correlations. Cross-lagged panel mediation analysis was conducted using Mplus 8.3, with bootstrapping employed to test indirect effects.ResultsResults indicated that sense of coherence significantly predicted positive affect (β = 0.259–0.369, p &lt; 0.001). Positive affect, in turn, predicted physical exercise (β = 0.083–0.182, p &lt; 0.05), while negative affect also influenced physical exercise (β = −0.096–0.203, p &lt; 0.05). Physical exercise indirectly influenced positive affect through sense of coherence (β = 0.037, p = 0.045), and positive affect indirectly influenced physical exercise through sense of coherence (β = 0.029, p = 0.028). Other indirect effects involving physical exercise, sense of coherence, and negative affect were non-significant.ConclusionThis study underscores the importance of sense of coherence in promoting emotional well-being among university students and in the reciprocal relationship between physical exercise and positive emotional states. Findings suggest that interventions targeting sense of coherence may enhance the emotional benefits of physical exercise. Future research should explore other potential mediators and moderators of the relationship between physical exercise and emotions and examine the effectiveness of sense of coherence-based interventions on well-being in this population.
Psychometric properties of lift and carry test in assessing people with stroke
Authors: Chen Peiming , Tse Mimi M. Y , Ng Shamay S.M. , Ho Leo C. M. , Kwok Anthony T. C. , Lam Sam C. Y. , Liu Tai Wa , Wong Thomson W. L. , So Billy C. L. , Lai Cynthia Y. Y. 
Published: August 2024

ObjectiveTo investigate the psychometric properties of the Lift and Carry Test (LCT) time in people with stroke.DesignCross-sectional design.SettingUniversity based neurorehabilitation laboratory.ParticipantsTwenty-four people with stroke and 24 healthy controls.Outcome measuresLift and Carry Test (LCT), Fugl-Meyer Assessment of upper extremity and lower extremity, ankle dorsiflexor and plantarflexor muscle strength, Berg Balance Scale (BBS), Timed Up and Go (TUG) and Community Integration Measure.ResultsThe mean LCT time (29.70s) in people with stroke was more than double of that in healthy controls (13.70s). The LCT showed excellent intra-rater, inter-rater and test–retest reliability [intraclass correlation coefficient (ICC) = 0.943–1.000]. The LCT times demonstrated a significant negative correlation with the BBS score (rs = −0.771) and significant positive correlations with the TUG times (rs = 0.933). There was no significant correlation between LCT times and FMA score (p &gt; 0.05). An optimal cut-off LCT time of 15.48 s (sensitivity = 95.8%, specificity = 87.5%) was identified to differentiate between people with stroke and healthy controls (area under the curve = 0.957).ConclusionLCT is an excellent clinical test for examining advanced functional ability in people with stroke and distinguishing people with stroke from healthy controls.
Surgical outcomes and risk factors for overall mortality in brain arteriovenous malformations patients: a retrospective analysis
Authors: Miron Ioana , Pruna Viorel M. , Visarion Dan M. , Petrescu George E. D. , Gorgan Radu M. 
Published: August 2024

BackgroundBrain arteriovenous malformations (AVMs) are challenging vascular lesions. Extensive follow-up studies are necessary to refine the therapeutic algorithm, and to improve long-term survival in these patients. The aim of the study was to assess surgical outcomes, and to evaluate overall long-term mortality in patients treated for brain AVMs.MethodsThis retrospective single-center study included 191 patients with brain AVMs, admitted between 2012 and 2022. Clinical and angiographical particularities have been analyzed, to identify factors that might influence early outcome and overall long-term mortality.ResultsOut of 79 patients undergoing surgery, 51 had ruptured AVMs with total resection achieved in 68 cases (86.1%). Deep venous drainage was associated with incomplete resection. Female sex, admission modified Rankin Scale (mRS) &gt; 2, and eloquent location were independent predictors of poor outcomes. Multiple venous drainage was associated with a higher risk of worsened early outcome. Eloquent brain region involvement, conservative treatment, increasing age, admission mRS &gt; 2, and comorbidities significantly decrease survival in brain AVM patients. Patients treated with interventional treatments had significantly better survival than the conservatively managed ones, when adjusting for age and admission mRS.ConclusionThe study identified female sex, poor neurologic status on admission and eloquence as independent prognostic factors for a negative outcome after surgery. Patients who received interventional treatment had significantly better survival than patients managed conservatively. We recommend employing tailored, proactive management strategies as they significantly enhance long-term survival in brain AVM patients.
Clinicopathological and molecular features of tubo-ovarian carcinosarcomas: a series of 51 cases
Authors: Liang Fan , Shi Yue , Chen Yiqing , Tao Xiang , Ding Jingxin 
Published: August 2024

ObjectiveTubo-ovarian carcinosarcomas are rare, extremely aggressive malignant tumors that contain both carcinomatous and sarcomatous components. Due to the disease’s rarity, developing an effective treatment strategy for ovarian carcinosarcomas has been challenging. A study was conducted to investigate the clinicopathologic and molecular features of this rare disease.MethodsWe enrolled all patients diagnosed with tubo-ovarian carcinosarcomas from January 2007 to December 2022. The clinical and pathological data were gathered from medical records. Kaplan–Meier curves were plotted to calculate OS and PFS. The Log-rank test and Cox regression model were utilized to explore the relationship between clinicopathological parameters and survival. Patients with cancer tissues available had sequencing with a 242-gene panel done to investigate the mutational landscape and signature of the disease.ResultsIn total, 65% of the patients were diagnosed with advanced-stage cancer. The median PFS and OS of this cohort were 27 and 40 months, respectively, and there was no significant difference in survival between the homologous and heterologous components of sarcoma. Unexpectedly, staging did not have effects on prognosis. All patients had surgical attempts, and suboptimal debulking status was correlated with poorer PFS and OS. MSI was identified in 0% with low Tumor mutation burden (TMB) indicating a poor response to immunotherapy. Low HER2 expression is controversial, according to previous reports, and gives us limited choices with this rare and aggressive disease. We surprisingly found the homologous recombination deficiency (HRD)-positive status was identified in 64% of OCS, which is significantly higher than UCS and other types of epithelial ovarian cancer. The fact that all patients in our cohort who received olaparib as maintenance therapy had survived over 30 months and two had no evidence of recurrence at the latest follow-up might further validate the role of poly (ADP-ribose) polymerase inhibitors (PARPi) in the management of OCS.ConclusionOCS patients seemed to respond to carboplatin/paclitaxel with optimal PFS and OS. Cytoreduction with no residuals proved to be the sole independent prognostic factor. WES should be done to assess the prognosis and assist with the targeted therapy, especially the HRD test, which might help select potential patients who benefit from PARPi.
Supportive care needs, quality of life and social support among elderly colorectal cancer patients undergoing chemotherapy: a longitudinal study
Authors: Lian Siqin , Hou Xijie , Liu Weichen , Li Ming , Chen Guolian , Ling Ying 
Published: August 2024

ObjectiveThe purpose of this study is to examine the changes in supportive care needs, quality of life and social support during different chemotherapy cycles among elderly colorectal cancer patients.MethodsThis prospective longitudinal study recruited 160 elderly colorectal cancer patients using convenience sampling at a hospital in Guangxi between August 2023 and April 2024. To assess supportive care needs, quality of life, and social support, we used a short form of the Supportive Care Needs Survey (SCNS-SF34), a Functional Assessment of Cancer Therapy-colorectal (FACT-C), and a perceived social support scale (PSSS) prior to chemotherapy, as well as after the first, third, and sixth cycles. Repeated measures analysis of variance was used to validate the changes over time in supportive care needs, quality of life, and social support.Results155 participants completed all questionnaire sessions across the six cycles. From pre-chemotherapy until after the sixth cycle of chemotherapy, the extent of physical and daily living requirements among all respondents fluctuated between 47.23% and 88.26%, psychological needs ranged from 60.84% to 97.67%, patient care and support needs ranged from 83.75% to 99.35%, healthcare system and information needs varied from 85.98% to 99.00%, while the level of sexual needs decreased from 1.51% to 0.65%. The mean SCNS-SF34 scores for these participants ranged between 103.81 ± 2.28 and 144.10 ± 1.08. Significant increases over time were seen for all domains of SCNS-SF34 (F=126.99, 347.41, 65.00, 72.34, 160.15, p&lt;0.001), keeping a clear upward trend, except for sexual needs(F=0.712, p=0.546). The mean FACT-T scores dropped from 68.80 ± 1.00 to 51.24 ± 1.40, while the mean PSSS scores dropped from 55.77 ± 0.83 to 43.28 ± 1.05. The scores of FACT-T and PSSS showed statistically significant differences (F=231.21, 112.28, p&lt;0.001), maintaining clear downward trends.ConclusionDuring chemotherapy, elderly colorectal cancer patients continue to require high levels of supportive care, while their quality of life and social support gradually decline. This study offers healthcare practitioners a foundational understanding to identify and address the supportive care needs of elderly colorectal cancer patients across various chemotherapy phases, which facilitates the development of tailored strategies aimed at enhancing patients’ quality of life.
Barleriside A, an aryl hydrocarbon receptor antagonist, ameliorates podocyte injury through inhibiting oxidative stress and inflammation
Authors: Li Xiao-Jun , Wang Yan-Ni , Wang Wen-Feng , Nie Xiaoli , Miao Hua , Zhao Ying-Yong 
Published: August 2024

IntroductionIncreasing evidence shows that hyperactive aryl hydrocarbon receptor (AHR) signalling is involved in renal disease. However, no currently available intervention strategy is effective in halting disease progression by targeting the AHR signalling. Our previous study showed that barleriside A (BSA), a major component of Plantaginis semen, exhibits renoprotective effects.MethodsIn this study, we determined the effects of BSA on AHR expression in 5/6 nephrectomized (NX) rats. We further determined the effect of BSA on AHR, nuclear factor kappa B (NF-ƙB), and the nuclear factor erythroid 2-related factor 2 (Nrf2) signalling cascade in zymosan-activated serum (ZAS)-stimulated MPC5 cells.ResultsBSA treatment improved renal function and inhibited intrarenal nuclear AHR protein expression in NX-treated rats. BSA mitigated podocyte lesions and suppressed AHR mRNA and protein expression in ZAS-stimulated MPC5 cells. BSA inhibited inflammation by improving the NF-ƙB and Nrf2 pathways in ZAS-stimulated MPC5 cells. However, BSA did not markedly upregulate the expression of podocyte-specific proteins in the ZAS-mediated MPC5 cells treated with CH223191 or AHR siRNA compared to untreated ZAS-induced MPC5 cells. Similarly, the inhibitory effects of BSA on nuclear NF-ƙB p65, Nrf2, and AHR, as well as cytoplasmic cyclooxygenase-2, heme oxygenase-1, and AHR, were partially abolished in ZAS-induced MPC5 cells treated with CH223191 or AHRsiRNA compared with untreated ZAS-induced MPC5 cells. These results indicated that BSA attenuated the inflammatory response, partly by inhibiting AHR signalling.DiscussionBoth pharmacological and siNRA findings suggested that BSA mitigated podocyte lesions by improving the NF-ƙB and Nrf2 pathways via inhibiting AHR signalling. Therefore, BSA is a high-affinity AHR antagonist that abolishes oxidative stress and inflammation.