bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cheminformatics-aided pharmacovigilance: application to Stevens-Johnson Syndrome
Authors: Low Yen S , Caster Ola , Bergvall Tomas , Fourches Denis , Zang Xiaoling , Norén G Niklas , Rusyn Ivan , Edwards Ralph , Tropsha Alexander 
Published: October 2015

Abstract
Objective Quantitative Structure-Activity Relationship (QSAR) models can predict adverse drug reactions (ADRs), and thus provide early warnings of potential hazards. Timely identification of potential safety concerns could protect patients and aid early diagnosis of ADRs among the exposed. Our objective was to determine whether global spontaneous reporting patterns might allow chemical substructures associated with Stevens-Johnson Syndrome (SJS) to be identified and utilized for ADR prediction by QSAR models.
Materials and Methods Using a reference set of 364 drugs having positive or negative reporting correlations with SJS in the VigiBase global repository of individual case safety reports (Uppsala Monitoring Center, Uppsala, Sweden), chemical descriptors were computed from drug molecular structures. Random Forest and Support Vector Machines methods were used to develop QSAR models, which were validated by external 5-fold cross validation. Models were employed for virtual screening of DrugBank to predict SJS actives and inactives, which were corroborated using knowledge bases like VigiBase, ChemoText, and MicroMedex (Truven Health Analytics Inc, Ann Arbor, Michigan).
Results We developed QSAR models that could accurately predict if drugs were associated with SJS (area under the curve of 75%–81%). Our 10 most active and inactive predictions were substantiated by SJS reports (or lack thereof) in the literature.
Discussion Interpretation of QSAR models in terms of significant chemical descriptors suggested novel SJS structural alerts.
Conclusions We have demonstrated that QSAR models can accurately identify SJS active and inactive drugs. Requiring chemical structures only, QSAR models provide effective computational means to flag potentially harmful drugs for subsequent targeted surveillance and pharmacoepidemiologic investigations.
Text message reminders do not improve hepatitis B vaccination rates in an Australian sexual health setting
Authors: McIver Ruthy , Dyda Amalie , McNulty Anna M , Knight Vickie , Wand Handan C , Guy Rebecca J 
Published: October 2015

Abstract
Objective To evaluate the impact of text message reminders (short messaging service (SMS)) on hepatitis B virus (HBV) vaccination completion among high risk sexual health center attendees.
Materials and Methods In September 2008, Sydney Sexual Health Centre implemented an SMS reminder system. The authors assessed the impact of the reminder system on HBV vaccination rates among patients who initiated a course. The authors used a chi-square test and multivariate logistic regression to determine if SMS reminders were associated with second and third dose vaccine completion, compared with patients prior to the intervention.
Results Of patients sent SMS reminders in 2009 (SMS group), 54% (130/241) received 2 doses and 24% (58/241) received 3 doses, compared to 56% (258/463) ( P  = 0.65) and 30% (141/463) ( P  = 0.07) in the pre-SMS group (2007), respectively. Findings did not change after adjusting for baseline characteristics significantly different between study groups. There were no significant differences in completion rates among people who injected drugs, HIV-negative gay and bisexual men (GBM), and HIV-positive GBM. Among sex workers, travelers, and people who reported sex overseas, second and third dose completion rates were significantly lower in the SMS group compared to the pre-SMS group. In the SMS group, 18% of those who only had one dose attended the clinic within 1–18 months and 30% of those who had 2 doses attended in 6–18 months, but vaccination was missed.
Discussion SMS reminders did not increase second or third vaccine dose completion in this population.
Conclusion Clinician prompts to reduce missed opportunities and multiple recall interventions may be needed to increase HBV vaccination completion in this high risk population.
Penetrating and Intrastromal Corneal Arcuate Incisions in Rabbit and Human Cadaver Eyes: Manual Diamond Blade and Femtosecond Laser-Created Incisions
Authors: Gray Brad , Binder Perry S. , Huang Ling C. , Hill Jim , Salvador-Silva Mercedes , Gwon Arlene 
Published: October 2015

Objectives:
To compare morphologic differences between freehand diamond or femtosecond laser-assisted penetrating and intrastromal arcuate incisions.

Methods:
Freehand diamond blade, corneal arcuate incisions (180° apart, 60° arc lengths) and 150 kHz femtosecond laser (80% scheimpflug pachymetry depth corneal thickness) arcuate incisions were performed in rabbits. Intrastromal arcuate incisions (100 μm above Descemet's membrane, 100 μm below epithelium) were performed in rabbit corneas (energy 1.2 μJ, spot line separation 3 × 3 μm, 90° side cut angle). Eyes were examined by slit lamp and light microscopy up to 47 days post-procedure. Freehand diamond blade penetrating incisions, and femtosecond laser penetrating and intrastromal arcuate incisions (energy 1.8 μJ, spot line separation 2 × 2 μm) were performed in cadaver eyes. Optical coherence tomography was performed immediately after surgery and the corneas were fixed for light scanning and transmission electron microscopy.

Results:
The rabbit model showed anterior stromal inflammation with epithelial hyperplasia in penetrating blade and laser penetrating wounds. The laser intrastromal and penetrating incisions showed localized constriction of the stromal layers of the cornea near the wound. In cadaver eyes, penetrating wound morphology was similar between blade and laser whereas intrastromal wounds did not affect the cornea above or below incisions.

Conclusion:
Penetrating femtosecond laser arcuate incisions have more predictable and controlled outcomes shown by less post-operative scarring than incisions performed with a diamond blade. Intrastromal incisions do not affect uncut corneal layers as demonstrated by histopathology. The femtosecond laser has significant advantages in its ability to make intrastromal incisions which are not achievable by traditional freehand or mechanical diamond blades.
The influence of planning, support and self-concordance on goal progress and job satisfaction
Authors: van Dierendonck Dirk 
Published: October 2015

Purpose– The purpose of this paper is to test the combined influence of working towards self-concordant goals with goal planning and supervisory support on goal progress and job satisfaction.Design/methodology/approach– The data were collected among prison guards. The analysis takes into account a multilevel perspective on goals by differentiating between within- and between-person variance.Findings– The results showed that there was no direct effect of self-concordance on goal progress. Goal progress depended on combining self-concordant goals with conscious planning and receiving supervisory support. Furthermore, it was found that job satisfaction and goal progress influenced each other over time.Research limitations/implications– The findings confirm that to understand the influence of self-concordant goals within organizations, planning and supervisory support are essential elements for achieving goal progress. This research is the first to confirm the interrelatedness of goal progress and job-satisfaction over time.Originality/value– The multilevel intra and interpersonal approach provides a more thorough insight into the processes involved with goal striving. It emphasizes the importance of differentiation between the different levels of motivation in Deci and Ryan’s self-determination theory, especially when applied within the work context.
The sensitivity of payouts to corporate financing decisions
Authors: Hoang Edward C. , Hoxha Indrit 
Published: October 2015

Purpose
– The purpose of this article is to empirically explore the sensitivity of payouts to cash flows and the other financing decisions, such as debt and investment, of firms.

Design/methodology/approach
– Using panel regressions based on COMPUSTAT data for 7,544 public firms during the period 1973–2013, we estimate the sensitivity of total payouts. Specifically, following the theory presented in Lambrecht and Myers (2012), we test the interdependent financing decisions of the firm. First, we compute total payout as the sum of cash dividends and net stock repurchases; second, we examine the sensitivity of total payouts to changes in the firm’s net income, debt and investment. Furthermore, we present several tests to demonstrate the robustness of our results.

Findings
– We suggest evidence in support of the theory in Lambrecht and Myers (2012) showing that there is a negative relationship between total payouts and investment. Furthermore, we find that total payouts are positively associated with net income and debt of the firm.

Originality/value
– Previous research has shown how cash flows affect different financing decisions, but it is not clear how total payouts are sensitive to other financing decisions. The focus of this paper is the response of total payouts to investment policy, debt financing policy and changes in cash flows.
Paths of the mind
Authors: Fox Robert 
Published: October 2015

Purpose
– This column aims to take a brief look at wayfinding in the digital age, and explores several opportunities that are on the horizon for libraries that could enhance the user experience for their patrons.

Design/methodology/approach
– This column provides a survey of the current views of wayfinding in the digital age.

Findings
– There is new technology being developed that increasingly blurs the lines between the digital and the physical.

Originality/value
– Devices such as the HoloLens and iBeacon, while nascent, will quickly become a standard for new approaches that people can use to interact with their environments integrating digital information. This affords libraries a unique opportunity over the course of the next 5-10 years to take advantage of this technology to assist patrons with their information needs.
Internal customer service assessment of cataloging, acquisitions, and library systems
Authors: Mugridge Rebecca , Poehlmann Nancy M. 
Published: October 2015

Purpose
– The purpose of this paper is to demonstrate that an internal customer service survey approach to assessment delivers many benefits to technical services and library systems units. Findings from such a survey provide the evidence needed to implement process improvements, conduct strategic planning and more. The survey used in this case study can be adapted by other libraries or library units to conduct assessment, gauge customer satisfaction and identify areas for process improvements.

Design/methodology/approach
– The Technical Services and Library Systems Division of the University at Albany Libraries conducted an internal customer service survey to gauge customer satisfaction with its services.

Findings
– Survey results demonstrated that customer surveys are a valuable assessment tool and can be used as an evidence-based approach to library management. Technical services and library systems units should use this tool to identify whether customers are satisfied with the services provided, whether the services are still needed, whether additional services are needed and more.

Practical implications
– This paper provides an approach to conducting a customer service survey, an analysis of potential benefits and a survey instrument that others could adapt to use in their own libraries. The survey instrument can be used not only for assessment of technical services and library systems, but by other functional units in all types of libraries.

Originality/value
– This paper and approach is original research; there are no other papers on this topic in the library and information science literature.
Updating controlled vocabularies by analysing query logs
Authors: Vállez Mari , Pedraza-Jiménez Rafael , Codina Lluís , Blanco Saúl , Rovira Cristòfol 
Published: October 2015

Purpose
– Controlled vocabularies play an important role in information retrieval. Numerous studies have shown that conceptual searches based on vocabularies are more effective than keyword searches, at least in certain contexts. Consequently, new ways must be found to improve controlled vocabularies. The purpose of this paper is to present a semi-automatic model for updating controlled vocabularies through the use of a text corpus and the analysis of query logs.

Design/methodology/approach
– An experimental development is presented in which, first, the suitability of a controlled vocabulary to a text corpus is examined. The keywords entered by users to access the text corpus are then compared with the descriptors used to index it. Finally, both the query logs and text corpus are processed to obtain a set of candidate terms to update the controlled vocabulary.

Findings
– This paper describes a model applicable both in the context of the text corpus of an online academic journal and to repositories and intranets. The model is able to: first, identify the queries that led users from a search engine to a relevant document; and second, process these queries to identify candidate terms for inclusion in a controlled vocabulary.

Research limitations/implications
– Ideally, the model should be used in controlled web environments, such as repositories, intranets or academic journals.

Social implications
– The proposed model directly improves the indexing process by facilitating the maintenance and updating of controlled vocabularies. It so doing, it helps to optimise access to information.

Originality/value
– The proposed model takes into account the perspective of users by mining queries in order to propose candidate terms for inclusion in a controlled vocabulary.
Synthesis of novel tetrasubstituted thiophenes based dye using sodium a-cyanoketene dithiolates as starting materials
Authors: Elgemeie G.H. , Ahmed K.A. , Ahmed E.A. , Helal M.H. , Masoud D.M. 
Published: October 2015

Purpose
– The study aims to synthesise new thiophene-based dyes by an efficient method using sodium a-cyanoketene dithiolates as starting components for synthesis of tetra-substituted thiophenes, which act as a coupler for the synthesised dye. The synthesised dyes are applied for printing polyamide and polyester fabrics using the screen printing technique.

Design/methodology/approach
– Treatment of 1 with carbon disulfide in alkaline medium forming disodium salt 2, which act as starting point for heterocyclisation to prepare these dye stuff 7. Sodium a-cyanoketene dithiolates 2 react with two moles of phenacyl bromide derivatives, forming alkylsulfanylthiophenes which react with the diazonium salt, forming the target dyestuff. These prepared dyes are used to print polyamide and polyester fabrics by using a synthetic thickener in the printing paste using screen-printing techniques.

Findings
– The structure of synthesised dyes were established and confirmed for the reaction products on the basis of their elemental analysis and spectral data (IR and 1H-NMR). The suitability of the prepared dyestuffs for screen printing on polyamide and polyester fabrics has been investigated. The prints obtained from dyes possess high colour strength as well as excellent overall fastness properties.

Research limitations/implications
– The diazo coupling reaction of the starting tetra-substituted thiophene 5 with diazotised aromatic amines resulted in the formation of the corresponding dye. The synthesised dyes were utilised in preparing a paste for polyester and polyamide fabric printing. In addition, both of the variations of the substituents on the synthesised dyes and the fastness properties were also studied.

Practical implications
– The synthesised dyes are superior in terms of yield, purity, colour strength and fastness properties, which lead to valuable achievements for commercial production.

Social implications
– The synthesised dyes are superior for application in fabrics.

Originality/value
– The synthesis for novel thiophene-based dye stuff for application in printing properties on polyester and polyamide fabrics and study their fastness properties.
Who owns educational research? Disciplinary conundrums and considerations
Authors: Marshall Bethan , Pahl Kate 
Published: October 2015

Purpose– The purpose of this paper is to consider the dynamics of submitting arts-based research in a climate that is dominated, in the UK, by the social sciences.Design/methodology/approach– It begins by taking a view on arts-based research, considering mainly Eisner and Dewey but exploring the possibilities of other forms such as baroque research. It goes on to look at some examples of arts-based research that has been carried out, funded by the Arts and Humanities Research Council. The authors conclude by saying that interdisciplinary research, while being encouraged by research councils, is also made more difficult by these same research councils’ funding structures.Findings– The authors consider that this has an effect on defining what educational research is and could be. The authors argue that this is important not only in relation to the range of disciplinary perspectives that can be drawn upon within educational settings, for example, the need to engage with disciplines such as English, History, Philosophy, Music and Fine Art, but also in relation to methodological understandings of how research should be conducted within educational settings.Originality/value– The research studies are arts based but with an original educational orientation.
In the thick of things: drama as a qualitative methodology
Authors: Vicars Mark , McKenna Tarquam 
Published: October 2015

Purpose
– The purpose of this paper is to consider how the drama space is a way of inquiry in its own right and as a complex “way of knowing” has a capacity to be a profitable location from which to artfully thread and critically interrogate the performances of lives-as-lived.

Design/methodology/approach
– The autoethnographic discussion has an overlay of histography as it brings the “real-life” word to the drama space and builds on naturalistic and experimental research moving the reader through transformational inquiry to what they name as drama as a post-foundational research method.

Findings
– In using drama as artful practices, intra-reflexivity – interior focused – felt as artistic “process” leads “psyche” to an empathic space for acceptance of the fugitive selves and demonstrates “queerness” through the narratives as monologues.

Research limitations/implications
– The vignettes presented as monologue attest to the authors’ life histories and their “fugitive” ways of being as gay men.

Practical implications
– The authors consider how drama as methodological practice can re work the notion of text-to-life or life-to-text, as an expression of a will to knowledge, of the authors working dramatically with their participants and students to find a way to articulate experience and place at the centre of research an agentic voice in relation to psychological, socio-cultural and historical interpretations.

Originality/value
– Drama, as a methodological approach, has, the authors suggest, the potential to move beyond disembodied and abstract mental processes and to draw out of the closets the interpersonal relationships that have historically been seen as dangerous or disturbing.
Nutrition knowledge of dietetic undergraduate students: An exploratory study
Authors: Lawrence Kristin , Pelly Fiona , Rocks Tetyana 
Published: October 2015

AbstractAimTo describe the level of nutrition knowledge in students undertaking an accredited nutrition and dietetics (ND) undergraduate program in reference to students enrolled in non‐accredited nutrition (NUT) or occupational therapy (OT) programs. The secondary aim was to investigate the variation in nutrition knowledge of ND students.MethodsStudents enrolled in ND, NUT or OT undergraduate programs at an Australian university were invited to participate in an online survey in August 2013. Nutrition knowledge levels were measured using the validated Re‐examined General Nutrition Knowledge Questionnaire (R‐GNKQ). Socio‐demographic characteristics and sources of nutrition information were also collected.ResultsStudents in the first year of ND or NUT programs had significantly higher overall scores than the OT students (P = 0.046 and P = 0.005, respectively). Substantially greater overall scores were observed for the students in the second year of the ND program than those in the first year (P = 0.01). The highest level of nutrition knowledge was observed in third year ND students. Overall score for ND students was influenced by year level and previous education, but there were no differences detected for gender, age, living situation or ethnicity.ConclusionsND students entered the program with high nutrition knowledge levels. The dietetic program appeared to develop the general nutrition knowledge of students to a level comparable to practising dietitians. Research investigating underlying knowledge development is necessary to direct dietetic curriculum design and delivery.
Effects of Fermentation Temperature on Key Aroma Compounds and Sensory Properties of Apple Wine
Authors: Peng Bangzhu , Li Fuling , Cui Lu , Guo Yaodong 
Published: October 2015

AbstractFermentation temperature strongly affects yeast metabolism during apple wine making and thus aromatic and quality profiles. In this study, the temperature effect during apple wine making on both the key aroma compounds and sensory properties of apple wine were investigated. The concentration of nine key aroma compounds (ethyl acetate, isobutyl acetate, isopentylacetate, ethyl caprylate, ethyl 4‐hydroxybutanoate, isobutylalcohol, isopentylalcohol, 3‐methylthio‐1‐propanol, and benzeneethanol) in apple wine significantly increased with the increase of fermentation temperature from 17 to 20 °C, and then eight out of the nine key aroma compounds with an exception of ethyl 4‐hydroxybutanoate, decreased when the temperature goes up 20 to 26 °C. Sensory analysis showed that the apple wine fermented at 20 °C had the highest acceptance for consumers. Fermentation at the temperature of 20 °C was therefore considered to be the most suitable condition using the selected yeast strain (Saccharomyces cerevisiae AP05) for apple wine making. Changes in the fermentation temperature can considerably affect the production of key aroma compounds and sensory profiles of apple wine. These results could help apple wine producers make better quality production for consumers at the optimal fermentation temperature.