bluuebunny/crossref_metadata_2025_split huggingface dataset:
Personalized care in dilated cardiomyopathy: Rationale and study design of the activeDCM trial
Authors: Sedaghat‐Hamedani Farbod , Amr Ali , Betz Theresa , Kayvanpour Elham , Reich Christoph , Wettstein Reto , Heinze Oliver , Mohr Isabell , Krisam Regina , Sander Anja , Klose Christina , Friedmann‐Bette Birgit , Frey Norbert , Meder Benjamin 
Published: July 2024

AbstractBackgroundDilated cardiomyopathy (DCM) is a leading cause of heart failure, particularly in younger individuals. Low physical strength is a global risk factor for cardiovascular mortality, and physical activity and a healthy lifestyle have been shown to improve outcomes in patients with heart failure. However, inappropriate exercise may increase the risk of arrhythmias in certain individuals with DCM. The determinants for predicting individual risks in this setting are poorly understood, and clinicians are hesitant to recommend sports for cardiomyopathy patients. The activeDCM trial aims to assess the safety and efficacy of a personalized exercise and activity programme for individuals with DCM.Study DesignThe activeDCM trial is a prospective, randomized, interventional trial with a 12 month follow‐up. Three hundred patients, aged 18–75 years with DCM, left ventricular ejection fraction (LVEF) ≤ 50% and New York Heart Association (NYHA) classes I–III, will be enrolled. The intervention includes a personalized exercise and activity programme. The primary outcome is the increase in peak oxygen uptake (VO2max, mL/kg/min) from baseline to 12 months. Secondary endpoints include adherence to personalized activity programmes, freedom from clinically relevant arrhythmia, unplanned hospitalization for heart failure and changes in NYHA class, quality of life scores, 6 min walk distance, muscular strength, N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) and high‐sensitivity troponin T (hsTnT) levels and cardiac function. Advanced research questions include high‐density phenome and omics analysis combined with digital biomarkers derived from Apple Watch devices.DiscussionThe activeDCM trial will provide valuable insights into the safety and efficacy of personalized exercise training in DCM patients, inform clinical practice and contribute to the development of heart failure management programmes. The study will generate data on the impact of exercise on various aspects of cardiovascular disease, including genetic, metabolic, phenotypic and longitudinal aspects, facilitating the development of future digital tools and strategies, including the incorporation of smart wearable devices.
Synthesis, Structure, and Properties of 1,3‐Diaryl‐7‐imino‐1,7‐dihydrobenzo[e][1,2,4]triazines: Products of Unexpected Conversion of Polyfluorinated Blatter Radicals
Authors: Gulyaev Dmitry , Serykh Andrey , Gadimov Nurlan , Shangin Pavel , Syroeshkin Mikhail , Sosunov Egor , Tretyakov Evgeny 
Published: July 2024

AbstractDerivatives of the first substituted 7‐imino‐1,7‐dihydrobenzo[e][1,2,4]triazines, namely 1‐(2,3,5,6‐tetrafluoropyridin‐4‐yl)‐N,3‐diphenyl‐7‐(phenylimino)‐1,7‐dihydrobenzo[e][1,2,4]triazin‐6‐amine and 1‐(pentafluorophenyl)‐N‐phenyl‐7‐(phenylimino)‐3‐(2,3,4,5‐tetrafluorophenyl)‐1,7‐dihydrobenzo[e][1,2,4]triazin‐6‐amine, were unexpectedly isolated as the only products in yields of about 20–30 % after an attempt to obtain Blatter radicals from the corresponding amidrazones bearing polyfluorinated electron‐withdrawing substituents. All new compounds were fully characterized, and their molecular and crystal structure was determined by single‐crystal X‐ray diffraction.
Adverse childhood experiences, brain efficiency, and the development of pain symptoms in youth
Authors: Miller Samantha , Cobos Karen L. , Rasic Nivez , Long Xiangyu , Lebel Catherine , Bar Am Neta , Noel Melanie , Kopala‐Sibley Daniel , Mychasiuk Richelle , Miller Jillian Vinall 
Published: July 2024

AbstractBackgroundAdverse childhood experiences (ACEs) are often reported by youths with chronic pain, and both ACEs and chronic pain disrupt how information is processed. However, it is unknown whether changes to shared neural networks underlie the relationship between ACEs and the development of pain symptoms. This study explored the relationships between ACEs, brain efficiency, and pain symptomology in youth.MethodsA community sample of youths aged 14–18 years underwent MRIs, answered trauma and pain questionnaires, and underwent pain sensory testing, twice, 3 months apart (Nbaseline = 44; Nfollow‐up = 42). Sensory testing determined thresholds for mechanical and thermal stimuli. Global and local network efficiencies were evaluated using graph theory. Generalized estimating equations were applied to examine whether brain efficiency moderated the relationships between ACEs, pain intensity, and pain sensitivity (i.e., mechanical detection, heat pain, and temperature change thresholds).ResultsThere was a significant interaction between ACEs and global brain efficiency in association with pain intensity (β = −0.31, p = 0.02) and heat pain (β = −0.29, p = 0.004). Lower global brain efficiency exacerbated the relationship between ACEs and pain intensity (θX → Y|W = −1.16 = 0.37, p = 0.05), and heat pain sensitivity (θX → Y|W = −1.30 = 0.44, p = 0.05). Higher global brain efficiency ameliorated the relationship between ACEs and pain intensity (θX → Y|W = 1.75 = −0.53, p = 0.05).ConclusionsThe relationship between ACEs and pain symptomology was comparable to chronic pain phenotypes (i.e., higher pain intensity and pain thresholds) and may vary as a function of brain efficiency in youth. This stresses the importance of assessing for pain symptoms in trauma‐exposed youth, as earlier identification and intervention are critical in preventing the chronification of pain.SignificanceThis article explores the relationship between ACEs, pain symptomology, and brain efficiency in youth. ACEs may affect how the brain processes information, including pain. Youths with lower brain efficiencies that were exposed to more ACEs have pain symptomology comparable to youths with chronic pain. Understanding this relationship is important for the earlier identification of pain symptoms, particularly in vulnerable populations such as youths exposed to trauma, and is critical for preventing the chronification of pain.
High efficient CuCeO2‐δ/SiO2 catalyst for RWGS reaction: impact of Ce content and loading sequence
Authors: Zhao Shan , Yang Le , Yao Shen , Dai Yahong , Chen Shuang , Zeng Jia , Jia Aiping , Xie Hongmei , Zhou Guilin 
Published: July 2024

AbstractThe extensive use of fossil energy leads to wanton emission of CO2 and serious environmental problems. The exploration of high‐performance catalysts plays a pivotal role in CO2 resource utilization. In this paper, CuCeyK catalysts are prepared by wet impregnation method using ordered mesoporous SiO2 as support for the reverse water gas shift (RWGS) reaction. The physicochemical properties of the prepared catalysts are characterized by H2‐TPR, BET, XRD, Quasi in‐situ XPS, H2‐TPD, and CO2‐TPD techniques. The results demonstrate thatthe Cu0 species can form synergistic effects with oxygen vacancies (Ov) to enhance the CuCeyK catalytic performance. Additionally, the electronic effects between Ce and Cu not only enhances the adsorption and activation performances of the catalyst towards CO2 and H2 molecules, but also effectively suppresses the sintering of Cu0 species, thereby enhancing the stability of the corresponding catalyst. It is worth mentioning that the Ce content also directly affects the catalytic performances of the CuCeyK catalyst. The CuCe15K catalyst with a Ce content of 15% displays excellent CO2 hydrogenation performances, and the CO2 conversion and CO selectivity up to 41 % and 100 % at 420 °C, respectively. © 2024 Society of Chemical Industry and John Wiley & Sons, Ltd.
Linear and weakly nonlinear analyses of double‐diffusive convection in porous media with chemical reaction using LTNE model
Authors: Ramchandraiah Chirnam , Kishan Naikoti , Reddy J. SharathKumar , Ravi Ragoju 
Published: July 2024

AbstractThe onset of convection in a horizontal porous layer with chemical reaction and local thermal nonequilibrium is investigated. The nondimensional governing equations have been solved using the normal mode technique, which results in an eigenvalue problem. The analytical expressions for both stationary and oscillatory Rayleigh numbers are obtained. The effect of different parameters has been investigated and presented. The amplitude equation is derived using weakly nonlinear theory. Nusselt number is calculated using an amplitude equation to investigate heat transport. When modeling a fluid‐saturated porous medium, previous research on double‐diffusive convection has uniformly operated under the assumption of local thermal equilibrium (LTE) between the fluid and solid phases at all points within the medium. This standard practice assumes a minimal temperature gradient between the phases at any given location. However, in practical scenarios involving high‐speed flows or significant temperature differentials between the fluid and solid phases, the LTE assumption proves insufficient.
Unravelling the spatiotemporal variation in the water levels of Poyang Lake with the variational mode decomposition model
Authors: Gan Min , Lai Xijun , Guo Yan , Lu Zhao , Chen Yongping , Pan Shunqi , Pan Haidong , Chu Ao 
Published: July 2024

AbstractPoyang Lake is a dynamic floodplain lake system that exhibits complex water level fluctuations and experiences significant regime changes over space and time, which remains to be further explored. This study used the variational mode decomposition (VMD) model to decompose the Poyang Lake's water levels from 1960 to 2022 at four key stations into six intrinsic mode functions (IMFs), namely IMF1–IMF6, representing variations on different time scales. The results present significant spatiotemporal heterogeneity. The multi‐year variation (IMF1) accounts for 5.6%–12.4% of the total variation and displays a northward decreasing trend, reflecting the lake's river‐like characteristics. The spectrum of IFM1 also reveals a significant 3.6‐year fluctuation mainly attributed to the tributary inflow, especially the Ganjiang River. The IMF1 differences between stations show abrupt decreases since the 2000s, indicating the impact of concentrated sand mining activities on the northern and central regions. The annual variation (IMF2) is the most prominent, contributing 76.1%–88.4% of the total variation, and shows a southward attenuation trend, likely due to the weakening influence of the Yangtze River flow. The intra‐annual scale (IMF3–IMF6) represents 6.0%–11.5% of the total variation and exhibits less spatial difference compared to the multi‐year and annual variations. The VMD model effectively separates the water level signals into different frequency bands, providing insights into the complex interactions between the lake, tributaries, and Yangtze River, as well as the impacts of human activities like sand mining, enhancing understanding of floodplain lake dynamics. The results also imply the importance of coping with the water level decline of Poyang Lake.
Deletion of the polyketide synthase‐encoding gene pks1 prevents melanization in the extremophilic fungus Cryomyces antarcticus
Authors: Catanzaro Ilaria , Gerrits Ruben , Feldmann Ines , Gorbushina Anna A. , Onofri Silvano , Schumacher Julia 
Published: July 2024

AbstractCryomyces antarcticus, a melanized cryptoendolithic fungus endemic to Antarctica, can tolerate environmental conditions as severe as those in space. Particularly, its ability to withstand ionizing radiation has been attributed to the presence of thick and highly melanized cell walls, which—according to a previous investigation—may contain both 1,8‐dihydroxynaphthalene (DHN) and L‐3,4 dihydroxyphenylalanine (L‐DOPA) melanin. The genes putatively involved in the synthesis of DHN melanin were identified in the genome of C. antarcticus. Most important is capks1 encoding a non‐reducing polyketide synthase (PKS) and being the ortholog of the functionally characterized kppks1 from the rock‐inhabiting fungus Knufia petricola. The co‐expression of CaPKS1 or KpPKS1 with a 4′‐phosphopantetheinyl transferase in Saccharomyces cerevisiae resulted in the formation of a yellowish pigment, suggesting that CaPKS1 is the enzyme providing the precursor for DHN melanin. To dissect the composition and function of the melanin layer in the outer cell wall of C. antarcticus, non‐melanized mutants were generated by CRISPR/Cas9‐mediated genome editing. Notwithstanding its slow growth (up to months), three independent non‐melanized Δcapks1 mutants were obtained. The mutants exhibited growth similar to the wild type and a light pinkish pigmentation, which is presumably due to carotenoids. Interestingly, visible light had an adverse effect on growth of both melanized wild‐type and non‐melanized Δcapks1 strains. Further evidence that light can pass the melanized cell walls derives from a mutant expressing a H2B‐GFP fusion protein, which can be detected by fluorescence microscopy. In conclusion, the study reports on the first genetic manipulation of C. antarcticus, resulting in non‐melanized mutants and demonstrating that the melanin is rather of the DHN type. These mutants will allow to elucidate the relevance of melanization for surviving extreme conditions found in the natural habitat as well as in space.
Superior accuracy in knee double level osteotomy using a novel hybrid fixation technique compared to conventional double plating
Authors: Mabrouk Ahmed , Monda Maureen , Bell Lucy , Broderick James , Dawson Matthew 
Published: July 2024

AbstractPurposeThis study aimed to compare two different double‐level knee osteotomy (DLO) fixation techniques. The primary outcome reported the radiological coronal plane correction and its accuracy. The secondary outcomes reported the correction outliers, the clinical outcomes, the 5‐year postoperative satisfaction and the complications.MethodsA retrospective review of a single surgeon osteotomy database identified 52 cases of DLO between 2011 and 2019, of which 24 cases met the inclusion criteria. Patients were categorised into two groups: the nail‐plate (NP) group fixed with a magnetic extendable intramedullary tibial nail and femoral conventional plate, and the double‐plate (DP) group fixed with conventional plates (tibia and femur). Radiographic parameters were recorded, including the mechanical femorotibial angle (mFTA), medial proximal tibial angle (MPTA), mechanical lateral distal femoral angle (mLDFA), joint line convergence angle (JLCA) and weight‐bearing line ratio (Mikulicz %). Surgical accuracy was calculated as the difference between the achieved and the planned correction. Outliers were defined as those with a greater than 10% difference from the planned correction. Simple knee value scores and visual analogue scale for pain were recorded preoperatively and postoperatively at 2 and 5 years. Five‐year patient satisfaction was recorded.ResultsA total of 24 patients were included: the NP group (n = 12) and the DP group (n = 12). Significant coronal plane corrections were achieved in the NP group for the mean mFTA (preoperative 167.9° ± 3.4° to postoperative 182.1° ± 1.4°), the mean MPTA (preoperative 83.5° ± 2.9° to postoperative 91.3° ± 2.8°) and the mean mLDFA (preoperative 89.8° ± 3.4° to postoperative 85.9° ± 4.4°). Similarly, significant coronal plane corrections were achieved in the DP group for the mean mFTA (preoperative 168.6° ± 4.4° to postoperative 182.2° ± 2°), the mean MPTA (preoperative 84.2° ± 2° to postoperative 88.3° ± 4.1°) and the mean mLDFA (preoperative 90.7° ± 2.9° to postoperative 83.9° ± 1.7°) (all p < 0.05). The mean correction accuracy was higher for the NP versus DP group at 3.4 ± 3.4% versus 7.1 ± 3.9% (intergroup p < 0.05). There were no outliers in the NP group versus two outliers (overcorrected) (16.7%) in the DP group. Significant clinical improvement was reported in both groups at 2 and 5 years postoperatively (all p < 0.05).ConclusionSuperior correction accuracy and no outliers were achieved in hybrid fixation double‐level knee osteotomy compared to the conventional double‐plating technique. The magnetic extendable nail offers the advantage of fine‐tuning the correction postoperatively and could be a potential research template for future designs of postoperative correction implants.Level of EvidenceLevel III, retrospective cohort study.
Evaluation of ventricular pacing suppression algorithms in dual chamber pacemaker: Results of “LEADER” study
Authors: Hwang Jongmin , Han Seongwook , Park Hyoung‐Seob , Chung Tae‐Wan , Jung Minsu , Park Seung‐Jung , Lee Chan‐Hee , Ahn Jin Hee , Choi Eue‐Keun , Bae Myung Hwan , Lee Young Soo , Park Sang Won , Lee Dae In , Kim Yoo‐Ri , Ahn Min‐Soo , Shim Jaemin 
Published: July 2024

AbstractBackgroundThere is limited research on the intra‐individual efficacy of ventricular pacing minimization algorithms developed by Biotronik—the Ventricular Pace Suppression algorithm (VpS) and the Intrinsic Rhythm Support plus algorithm (IRSplus) (BIOTRONIK SE & Co. KG, Berlin, Germany). We performed a randomized pilot trial that evaluated the efficacy of two algorithms in patients with symptomatic sinus node dysfunction (SND) who received a dual‐chamber pacemaker.MethodsThe trial was conducted in 11 tertiary hospitals in South Korea. The patients were randomized to either the VpS or IRSplus algorithm group after a 3‐month period of fixed atrioventricular (AV) delay. The primary outcome was the ventricular pacing percentage (Vp%) at each follow‐up visit. The secondary outcomes were the occurrence of heart failure (HF) and atrial fibrillation (AF) during the study period.ResultsData from 131 patients were analyzed. Initially, their average Vp% over 3 months with a fixed AV interval was 14.1 ± 19.4%. Patients were randomly assigned to VpS and IRSplus groups, with 66 and 65 in each. Algorithms reduced average Vp% to 4.0 ± 11.3% at 9 months and 6.7 ± 14.9% at 15 months. These algorithms were more effective for patients with paced AV delay (PAVD) ≤300 ms compared to those with PAVD >300 ms. Both algorithms were equally effective in reducing Vp%. Clinical AF or HF hospitalization was not observed during the study period.ConclusionThe VpS and IRSplus algorithms are effective and safe in minimizing unnecessary ventricular pacing in patients with SND.
Advancing on ametrine pesticide detection through surface‐enhanced Raman spectroscopy and Ag colloid: Understanding the pH effect and the adsorption mechanism supported by theoretical calculation
Authors: Rubira Rafael Jesus Gonçalves , Furini Leonardo Negri , Tuttolomondo Maria Eugenia , Constantino Carlos José Leopoldo , Sanchez‐Cortes Santiago 
Published: July 2024

AbstractThe excessive use of pesticides has detrimental effects on the ecosystem, leading to soil contamination and the spread of pollution beyond the targeted areas. Concerns arise regarding the permissible limits of pesticides, typically around 10−8 mol/L. In this study, we employed surface‐enhanced Raman spectroscopy (SERS), a highly sensitive and selective technique, to investigate the behavior of the pesticide ametrine (AMT) on silver colloids. The Ag nanoparticles (AgNPs) exhibited an average size of (26 ± 2) nm and a zeta potential of (−30 ± 1) mV in the absence of AMT, which decreased to (−24 ± 1) mV in the presence of AMT, resulting in mild AgNPs aggregation, with the average diameter of AgNPs increasing to approximately 300 nm. This aggregation is advantageous, as they provide active sites for pesticide detection. Besides, the purification method employed ensured that AMT remained undegraded, and various conformations of AMT were simulated using Ag clusters to study the SERS effect. Comparison with the experimental spectra indicated that the SERS‐4 conformer closely resembled the experimental spectrum, suggesting simultaneous interaction between the Ag surface and the sulfur (S) and nitrogen (N) atoms of the AMT triazine ring. Notably, changes in the AMT molecule were observed with pH variations: at pH below 5, hydroxylation occurred, resulting in an Ag–Cl stretching at 241 cm−1 in the SERS spectra. Conversely, at pH above 5 (pH 6–13), the presence of bands at 230 and 219 cm−1 in the SERS spectra indicate the formation of Ag–N and Ag–S bonds, respectively, between the AMT and the AgNPs. Furthermore, the study successfully detected AMT at pH 7, establishing a limit of detection (LOD) of 1.36 × 10−8 mol/L (3 ppb) based on the SERS spectra. These findings underscore the applicability of the SERS technique in the sensitive and selective detection of AMT, offering a promising approach for monitoring the presence of this pesticide in environmental samples.
The role of renewable energy and carbon dioxide emissions on the ESG market in European Union
Authors: Mohammed Kamel Si , Pata Ugur Korkut , Serret Vanessa , Kartal Mustafa Tevfik 
Published: July 2024

AbstractIn view of global climate problems, public interest in the environment has recently evolved over decision economics. Accordingly, this study assesses the impact of carbon emission allowances (CEA), information technology (IT), renewable energy generation (REG), and carbon dioxide (CO2) on the environmental, social, governance (ESG) in the European Union (EU) by applying quantile‐based models from January 2, 2019 to February 29, 2024. The outcomes demonstrate that CEA and IT have an increasing effect on the ESG with the moderating effect of economic policy uncertainty (EPU). REG has a declining effect on the ESG, while the EPU moderates the effect and makes the effect increasing across higher quantiles.
Long‐term outcome of fibula flaps in complex limb reconstruction compared to alternative procedures, a median follow up of 41 months
Authors: Challita Raymond , Forli Alexandra , Giot Jean‐Philippe , Corcella Denis 
Published: July 2024

AbstractIntroductionComplex open long bone fractures present a multidisciplinary surgical challenge. Various treatment options are discussed with no consensus. Fibula flaps (FF) are frequently used in maxillofacial surgery, however their use in limb injuries is less common. With the tremendous improvement in microsurgery, orthoplastic surgery gained importance. Our retrospective study aims to assess the long‐term results and the quality of life of the patients operated by FF for complex traumatic limb reconstruction.Patients and MethodsWe conducted an observational mono centric retrospective study from the year 2011 to the year 2021. Patients operated for complicated traumatic limb fractures using FF were included in the study. Not only long‐term clinical results were evaluated, but also Patient‐reported outcome measures (PROM). These included the Lower Extremity Functional Scale (LEFS), Quick Disabilities of the Arm, shoulder and hand (Qdash), and the Visual Analogue Scale (VAS). The statistical analysis was done using the R Software.ResultsTwenty patients were included in our study. 80% achieved complete union with no re fracture rate at a median follow‐up of 41 months. All of the patients (n = 4) who underwent amputation were smokers (p = .09), were operated for lower limb fractures (p = .54), and were males (p = 1). The length of hospital stay was associated with an increased duration to complete bony union (p = .01, coefficient = 2.88). At the end of follow‐up, the LEFS median score was 67 for the total population and 63.5 for the lower limb reconstructed sub group.ConclusionVFF is an important tool in the armamentarium of orthoplastic surgeons. Encouraging long term functional and clinical outcomes were obtained in patients with complex traumatic limb fractures.
Expanding Initiatives and Participation
Authors: Kymissis Ioannis (John) 
Published: July 2024

AbstractThis year's Display Week was the largest in‐person SID event with more than 8,500 participants. It included a broad range of exhibitors, papers, posters, demonstrations, special events, tutorials, seminars, awards, and keynotes. With so much going on, it was impossible to do and see everything!