bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serological immune biomarker for disease severity in dengue‐infected pediatric hospitalized patients
Authors: Pathak Bharti , Chakarvarty Aparna , Rani Nakka Veena , Krishnan Anuja 
Published: July 2024

AbstractClinical manifestation of dengue disease ranges from asymptomatic, febrile fever without warning sign (DOS) to serious outcome dengue with warning sign (DWS) and severe disease (SD) leading to shock syndrome and death. The role of antibody response in natural dengue infection is complex and not completely understood. Here, we aimed to assess serological marker for disease severity. Antibody response of dengue‐confirmed pediatric patients with acute secondary infection were evaluated against infecting virus, immature virus, and recombinant envelop protein. Immature virus antibody titers were significantly higher in DWS as compared to DOS (p = 0.0006). However, antibody titers against recombinant envelop protein were higher in DOS as compared to DWS, and antibody avidity was significantly higher against infecting virus in DOS. Serum samples of DOS patients displayed higher in vitro neutralization potential in plaque assay as compared to DWS, whereas DWS serum samples showed higher antibody‐dependent enhancement in the in vitro enhancement assays. Thus, antibodies targeting immature virus can predict disease severity and could be used in early forecast of disease outcome using an enzyme‐linked immunoassay assay system which is less laborious and cheaper than plaque assay system for correlates of protection and could help optimize medical care and resources.
Cubital vein access provides a practical alternative to internal jugular vein access for coronary sinus catheter placement
Authors: Tashiro Haruwo , Terata Ken , Kato Ryosuke , Wakabayashi Hiyu , Iwakawa Hidehiro , Watanabe Hiroyuki 
Published: July 2024

AbstractBackgroundInsertion of electrode catheters into the coronary sinus (CS) through the right internal jugular vein (RIJV) carries risks of pneumothorax and severe hematoma formation. This study was performed to compare the safety and feasibility of catheterization through the left cubital superficial vein versus the RIJV.MethodsThis prospective nonrandomized study involved consecutive patients who underwent catheter ablation from September 2021 to February 2023. Blind puncture techniques were used in the left cubital vein group; ultrasound‐guided insertion was performed in the RIJV group. The success rates of sheath insertion and CS catheterization, the procedure and fluoroscopy times of CS cannulation, and complications were compared between groups.ResultsThe left cubital vein group comprised 152 patients, and the RIJV group comprised 58 patients. The sheath insertion success rate was significantly lower in the cubital vein group than in the RIJV group (84.9% vs 100%, respectively; p = .0008). In the cubital vein group, blind puncture attempts failed in 20 patients; three patients developed guidewire‐induced venous injury. One arterial puncture occurred in the RIJV group. After successful sheath insertion, no significant differences were observed in the CS cannulation success rate (97% vs 100%, p = .55), procedure time (median [range], 93 [51–174] vs 74 [44–129] s; p = .19), or fluoroscopy time (median [range], 66 [36–134] vs 48 [30–92] s; p = .17). No serious complications requiring procedural discontinuation occurred.ConclusionThe left cubital vein approach is practical, offering a viable alternative to the RIJV approach.
Association between nonalcoholic fatty liver disease scores and chronic periodontitis: A retrospective cohort study
Authors: Joo Kwangmin , Kang Yeo Wool , Moon Sang Yi , Baek Yang Hyun , Son Minkook 
Published: July 2024

AbstractBackgroundAlthough several studies have demonstrated a bidirectional relationship between nonalcoholic fatty liver disease (NAFLD) and chronic periodontitis, few studies have reported that NAFLD causes chronic periodontitis, especially in the Asian population.MethodsThis study was conducted on 129,087 individuals, and the NAFLD score was assessed using the Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI), and Framingham Steatosis Index (FSI). The incidence of chronic periodontitis was defined as a diagnostic code with dental procedures. Multi‐variable adjusted Cox proportional hazard regression analysis was performed with hazard ratio (HR) and 95% confidence intervals (CIs).ResultsNine thousand one hundred and twenty‐eight chronic periodontitis cases (7.1%) were identified during a mean 7.4 years follow‐up period. Each NAFLD score was related to chronic periodontitis. In the FLI score, HR and 95% CIs for the incidence of chronic periodontitis compared with a low FLI group were as follows: indeterminate FLI: 1.19 (1.12–1.26), high FLI: 1.32 (1.18–1.47). In the HSI and FSI scores, HR and 95% CIs for the incidence of chronic periodontitis were 1.13 (1.05–1.22) and 1.23 (1.05–1.31), respectively.ConclusionsAll NAFLD scores were associated with chronic periodontitis in the Korean population. As chronic periodontitis can aggravate the liver status, patients with NAFLD may need regular dental visits.
Translating virtual product scarcity in gaming to real‐world brand value
Authors: Fukuda Reo , Nomura Takuya , Akamatsu Naoki 
Published: July 2024

AbstractThis study explores how the scarcity of virtual products in virtual gaming spaces influences brand evaluation in the real world. While previous studies suggest that scarcity in virtual spaces can enhance brand value, the mechanisms and conditions under which this effect occurs (e.g., the characteristics of virtual spaces, consumer traits, and stimulus). Drawing on insights from scarcity research on physical products, we propose that the effects of scarcity may stem from the expectation of impression management. We developed a model that incorporates insights from physical product scarcity research with the unique aspects of virtual spaces and consumer characteristics. Through four studies, we discovered that the effect of supply scarcity in enhancing brand evaluation is pronounced when the space is online and when consumers have a high level of social presence. Furthermore, in cases where social presence is not high, encounters with others wearing scarce products were found to enhance the scarcity effect. Companies can enhance brand evaluation by strategically using virtual product scarcity in online gaming, particularly when targeting consumers with high social presence or creating opportunities for players to interact with others wearing scarce items.
Danmaku consistency reduces consumer purchases during live streaming: A dual‐process model
Authors: Zhang Nan , Ruan Chenhan 
Published: July 2024

AbstractDanmaku, a new type of real‐time electronic word‐of‐mouth (eWOM) for shopping during live streaming, was designed to be consistent when promoting products during live streaming to create an active atmosphere. However, the effect of danmaku consistency on consumer purchases has received limited attention. Specifically, the literature on eWOM consistency mainly considers valence consistency in information posted after purchase; it does not explore real‐time interactions under live‐streaming conditions. Therefore, from the perspective of consumer‐to‐consumer interactions, this research innovatively explores the negative impact of danmaku consistency (in both content and format) on consumer purchases. Based on three experiments, we find that danmaku consistency reduces consumer purchases during live streaming. This effect occurs through a dual‐process mechanism of psychological reactance and information richness. In addition, the above negative effect is attenuated by the moderating role of perceived intrinsic motivation to post danmaku. The findings contribute to the eWOM literature by shedding new light on the negative side of danmaku consistency during live streaming, and they provide practical suggestions for streamers and platforms for designing danmaku and increasing consumer engagement.
Monte Carlo simulations of microdosimetry and radiolytic species production at long time post proton irradiation using GATE and Geant4‐DNA
Authors: Fois Giovanna Rosa , Tran Hoang Ngoc , Fiegel Vincent , Blain Guillaume , Chiavassa Sophie , Craff Emeline , Delpon Grégory , Evin Manon , Haddad Ferid , Incerti Sébastien , Koumeir Charbel , Métivier Vincent , Mouchard Quentin , Poirier Freddy , Potiron Vincent , Servagent Noël , Vandenborre Johan , Maigne Lydia 
Published: July 2024

AbstractBackgroundRadiobiological effectiveness of radiation in cancer treatment can be studied at different scales (molecular till organ scale) and different time post irradiation. The production of free radicals and reactive oxygen species during water radiolysis is particularly relevant to understand the fundamental mechanisms playing a role in observed biological outcomes. The development and validation of Monte Carlo tools integrating the simulation of physical, physico‐chemical and chemical stages after radiation is very important to maintain with experiments.PurposeTherefore, in this study, we propose to validate a new Geant4‐DNA chemistry module through the simulation of water radiolysis and Fricke dosimetry experiments on a proton preclinical beam line.Material and methodsIn this study, we used the GATE Monte Carlo simulation platform (version 9.3) to simulate a 67.5 MeV proton beam produced with the ARRONAX isochronous cyclotron (IBA Cyclone 70XP) at conventional dose rate (0.2 Gy/s) to simulate the irradiation of ultra‐pure liquid water samples and Fricke dosimeter. We compared the depth dose profile with measurements performed with a plane parallel Advanced PTW 34045 Markus ionization chamber. Then, a new Geant4‐DNA chemistry application proposed from Geant4 version 11.2 has been used to assess the evolution of , , , , , , and reactive species along time until 1‐h post‐irradiation. In particular, the effect of oxygen and pH has been investigated through comparisons with experimental measurements of radiolytic yields for and Fe3+.ResultsGATE simulations reproduced, within 4%, the depth dose profile in liquid water. With Geant4‐DNA, we were able to reproduce experimental radiolytic yields 1‐h post‐irradiation in aerated and deaerated conditions, showing the impact of small changes in oxygen concentrations on species evolution along time. For the Fricke dosimeter, simulated G(Fe3+) is 15.97 ± 0.2 molecules/100 eV which is 11% higher than the measured value (14.4 ± 04 molecules/100 eV).ConclusionsThese results aim to be consolidated by new comparisons involving other radiolytic species, such as or to further study the mechanisms underlying the FLASH effect observed at ultra‐high dose rates (UHDR).
Efficacy and safety of onabotulinumtoxinA for the treatment of overactive bladder in men and women: A pooled analysis
Authors: Nitti Victor W. , Kohan Alfred , McCammon Kurt , Jenkins Brenda , Ifantides Kimberly Becker , Yushmanova Irina , Chapple Christopher 
Published: July 2024

AbstractBackgroundThis pooled analysis of randomized controlled studies investigated the safety and efficacy of onabotulinumtoxinA in male and female patients with overactive bladder (OAB).MethodsData were pooled from four similarly designed trials in North America and Europe. Adults with idiopathic OAB for ≥6 months inadequately managed by at least one anticholinergic were randomized 1:1 or 2:1 to receive onabotulinumtoxinA 100 U or matched placebo in Cycle 1 and could request open‐label retreatment with onabotulinumtoxinA 100 U at ≥12 weeks. Efficacy outcomes at Week 12 included the primary endpoint of mean urinary incontinence (UI) episodes per day and other variables, such as the proportion of patients with ≥50% reduction in daily UI episodes. Safety was assessed by monitoring treatment‐emergent adverse events (TEAEs). Analyses by sex were descriptive. Males were further analyzed by benign prostatic hyperplasia (BPH) diagnosis status.ResultsIn the pooled population (N = 1564), there were 194 males (12.4%) and 1370 females (87.6%). Mean number of baseline UI episodes per day was 4.9 in males and 5.5 in females. At Week 12, numerically greater mean reductions from baseline in number of daily UI episodes were observed with the onabotulinumtoxinA 100 U group (females: −3.0; males: −2.2) versus placebo (females: −1.1; males: −1.3). Achievement of ≥50% reduction in daily UI episodes was numerically greater with onabotulinumtoxinA 100 U (females: 64.8%; males: 61.2%) versus placebo (females: 30.6%; males: 44.8%), and numerically higher in males without BPH (onabotulinumtoxinA: 65.1%; placebo: 50.9%) versus with BPH (onabotulinumtoxinA: 54.3%; placebo: 36.6%). A total of 34.7% of males and 39.4% of females experienced at least one TEAE in the first 12 weeks during treatment Cycle 1. Urinary tract infection rate was 13.1% in females and 4.2% in males; incidence of hematuria was 6.8% in males and 1.1% in females. Incidence of urinary retention (defined as incomplete emptying, requiring catheterization) was 2.7% in females and 4.7% in males.ConclusionOnabotulinumtoxinA 100 U was efficacious and well tolerated in men and women with OAB, including in males with and without BPH. No new safety findings were identified when data were analyzed by sex.
The relationships between blood lead levels and nocturia prevalence in adults: A retrospective study
Authors: Wang Junwei , Wang Xin , Zhang Cunming , Zhang Aiwei 
Published: July 2024

AbstractPurposeThe purpose of this study was to examine the association between blood lead levels and the prevalence of nocturia in American adults.MethodsWe analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2020, focusing on individuals aged 20 years or older (n = 11,919). Blood lead levels were categorized into two groups (<2 µg/dL and ≥2 µg/dL), and the presence of nocturia was assessed based on questionnaire responses. We used multivariable logistic regression models to explore the association between blood lead levels and nocturia while adjusting for various covariates, including sex, ratio of family income to poverty (RIP), lipid profile, age, body mass index (BMI), race, citizenship, sleep trouble, diabetes, and hypertension. To verify whether certain covariates influence blood lead levels and the risk of nocturia, we conducted subgroup analyses.ResultsOf the study participants, 31.70% reported experiencing nocturia. Individuals with higher blood lead levels (≥2 µg/dL) exhibited a higher likelihood of experiencing nocturia compared to those with lower levels (<2 µg/dL) in all three models (Model 1: OR 1.46, 95% CI 1.29–1.66, p < 0.0001; Model 2: OR 1.25, 95% CI 1.09–1.44, p = 0.002; Model 3: OR 1.22, 95%CI 1.06–1.41, p = 0.01). Subgroup analyses revealed that factors such as age, sex, sleep trouble, diabetes, hypertension, BMI, RIP, and race did not affect the association between blood lead levels and the risk of nocturia (P for interaction >0.05).ConclusionsThis study reported the correlation between blood lead levels and nocturia. We found that compared to blood lead levels below 2 µg/dL, when lead levels reached or exceeded 2 µg/dL, the risk of nocturia occurrence increased by 22%.Clinical trial registrationThis study is based on existing data from a public database and not from a specific clinical trial; hence, clinical registration information is not provided.
Work‐Related Musculoskeletal Disorders in Endoscopic Sinus and Skull Base Surgery: A Systematic Review With Meta‐analysis
Authors: Campbell Raewyn G. , Zadro Joshua R. , Gamble Andrew R. , Chan Cliffton L. , Mackey Martin G. , Osie Gabriel , Png Lu Hui , Douglas Richard G. , Pappas Evangelos 
Published: July 2024

AbstractObjectiveEndoscopic sinus and skull base surgery has led to significant improvements in patient outcomes, yet may have come at a cost to surgeons' musculoskeletal (MSK) health. We aimed to determine the prevalence and characteristics of work‐related MSK disorders (WRMDs) in endoscopic sinus and skull base surgeons; to investigate contributing factors for WRMD in this population; and to evaluate the effectiveness of ergonomic interventions on the severity or prevalence of WRMD in this population.Data SourcesMedline, Embase, CINAHL, Web of Science, and Scopus from inception to April 2, 2024. A bibliographic examination was performed for further papers.Review MethodsInclusion criteria included original peer‐reviewed papers with work‐related MSK outcomes (prevalence, contributing factors, and interventions) relating to endoscopic sinus and/or skull base surgeons in any language.ResultsOf 25,772 unique citations, 37 studies met the inclusion criteria. The pooled lifetime, point, and 12‐month prevalences of WRMD were 75.9% (95% confidence interval; I2, 67.2%‐83.6%, I2 95.6%), 80.8% (77.0%‐84.3%, I2 98.0%), and 82.0% (71.8%‐90.3%, I2 60.96%) respectively. The neck, lumbar spine, and thoracic spine were the most commonly involved areas. One of 9 studies on contributing factors investigated discomfort as an outcome. The remainder focussed on surrogate outcomes (eg, posture, hand dysfunction). Two of the 13 intervention studies investigated pain or fatigue as an outcome. The remainder targeted posture, muscle activity, or workload.ConclusionWRMDs are highly prevalent in endoscopic sinus and skull base surgeons. Further studies focusing on the direct outcomes of WRMD such as pain are needed.
Assessing the Efficacy of Tragal Pumping in a Novel Tympanostomy Tube‐Rat Model
Authors: Hara Satoshi , Liu Xinyu , Shah Firasat Ali , Saeki Harumi , Orita Hajime , Sakyo Airi , Anzai Takashi , Takata Yusuke , Kamiya Kazusaku , Matsumoto Fumihiko , Gabrielson Kathleen 
Published: July 2024

AbstractObjectiveTragal pumping (TP) is a practice of pushing on the tragus to raise pressure within the external auditory canal and is a commonly recommended adjunctive maneuver believed to facilitate the introduction of ototopical medications into the middle ear cavity via a tympanostomy tube. To investigate the efficacy of TP in the penetration of eardrops into the middle ear cavity via tympanostomy tube, we established the novel tympanostomy tube‐rat model. We investigated the histology of the middle ear to determine the efficacy in moving fluid into the middle ear.Study DesignProspective controlled animal study.SettingAnimal laboratory in a university hospital.MethodsTen rats were recruited, and a tympanostomy tube insertion and green dye eardrops into outer ears were performed on bilateral ears. TP was performed only on 1 ear and was not applied on the other ear in each rat. Green dye in a middle ear cavity in hematoxylin and eosin‐stained temporal bone sections was evaluated by blinded experts in microscopic anatomy (staining grade) and by using Image J software (staining level). The results of these 2 methods were statistically validated.ResultsThe staining grade (P < .001) and the staining level (P < .001) were significantly higher in the ears which we applied TP than in the control ears. The results of 2 methods were significantly and positively correlated (r = .898, P < .001).ConclusionOur results showed that the TP accelerate the penetration of eardrops into the middle ear cavity in the tympanostomy tube‐rat model.
Update on the clinical applications of SGLTis: Insight to benefits beyond hypoglycemic and cardiorenal protection
Authors: Tao Shibing , Guo Shanlan , Tong Nanwei 
Published: July 2024

AbstractSodium glucose cotransporter inhibitor (SGLTi) drugs have been widely used in clinical practice. In addition to their benefits in hyperglycemia, heart failure (HF), and kidney disease, their effects on obesity, metabolic dysfunction‐associated steatotic liver disease (MASLD, formerly named nonalcoholic fatty liver disease [NAFLD]), polycystic ovarian syndrome (PCOS), abnormal lipid metabolism, hyperuricemia, obstructive sleep apnea syndrome (OSAS), anemia, and syndrome of inappropriate antidiuresis (SIAD, formerly named syndrome of inappropriate antidiuretic hormone [SIADH]) have been explored. In this review, we searched the data of clinical randomized controlled trials (RCTs) and meta‐analyses of SGLTis in patients with diabetes from the PubMed library between January 1, 2020, and February 1, 2024. According to our review, certain SGLTis exhibit relatively superior clinical safety and effectiveness for treating the abovementioned diseases. Proper utilization of SGLTis in these patients can provide additional medication options for patients with different disease scenarios. However, studies of SGLTis in these diseases are relatively rare, with shortcomings such as small sample sizes and short intervention periods. Therefore, further large‐scale, long‐term, well‐designed studies are needed to clarify the findings.
Hyperspectral imaging combined with machine learning for high‐throughput phenotyping in winter wheat
Authors: Kaur Sehijpreet , Kakani Vijaya Gopal , Carver Brett , Jarquin Diego , Singh Aditya 
Published: July 2024

AbstractUncrewed aerial vehicles (UAVs) are a highly successful and efficient method for phenotyping in plant breeding programs. This study explored using UAVs equipped with hyperspectral sensors to expedite breeders' decision‐making in selecting winter wheat (Triticum aestivum L.) genotypes with improved growth, biomass, leaf area, and canopy cover (CC). The hyperspectral image processing pipeline utilized for image analysis was described. The study was conducted with 2145 genotypes of winter wheat, and UAV‐based hyperspectral measurements were used to predict the phenotype. Reflectance measurements were taken at narrow wavelength intervals, spanning 400–2500 nm. For ground truthing, samples were collected from different parts of the field. These samples were used to evaluate various plant attributes, including CC, leaf area index, plant height, and dry biomass. The hyperspectral data were employed for computation of multiple vegetation indices (VIs), and to improve the prediction of plant traits, we employed partial least squares regression (PLSR) and random forest (RF) regression techniques on both the complete set of hyperspectral variables and the top 10 derived VIs. Our results show that using complete hyperspectral variables results in superior r, R2, and lower root mean square error for both models. We conclude that relying solely on linear regression models with VIs may not always result in accurate predictions of plant traits in winter wheat. However, combining these indices with the RF and PLSR algorithm significantly enhances the prediction accuracy. However, the performance of both PLSR and RF models shows minimal disparity, with only slight differences observed. This highlights the importance of utilizing appropriate machine learning algorithms for improved prediction of plant traits.
Maxwell‐f(Q)$f(Q)$ Theory
Authors: Nashed Gamal Gergess Lamee 
Published: July 2024

AbstractExploring the four‐dimensional AdS black hole is crucial within the framework of the AdS/CFT correspondence. In this research, four‐dimensional stationary and rotating AdS solutions in the framework of the gravitational theory are investigated, considering the charged scenario. Author's emphasis is on the power‐law ansatz, which consistent with observations and is deemed the most viable. Because this solution does not have an uncharged version or relate to general relativity, it falls into a new category, which derives its features from changes in non‐metricity and incorporates the Maxwell domain. The singularities of such a solution are analyzed, computing all the quantities of different curvature and non‐metricity invariants. Author's results indicate the presence of a central singularity, albeit with a softer nature compared to standard non‐metricity or Einstein general relativity, attributed to the influence of the effect of . Several physical characteristics of black hole from thermodynamics perspective and demonstrate the existence of an outer event horizon in addition to the inner Cauchy horizons are examined. However, under the conditions of sufficiently large electric charge, a naked singularity emerges. Finally, a class of rotating black hole in four‐dimensional gravity that are asymptotically anti‐de Sitter charged is derived.