bluuebunny/crossref_metadata_2025_split huggingface dataset:
Security, Society, and the Perennial Struggles over the Sacred: Revising the Wars of Religion in International Relations Theory
Authors: Bolton Derek 
Published: August 2024

AbstractInternational relations theory tends to build on the conventional narrative of the Wars of Religion (WoR), which holds it was the irrationality of religious violence that generated the modern international system of pragmatic secular states—resulting in the presumed secularized, rational, and unemotive nature of politics. In contrast, this article reorients our focus to Durkheim's more social view of religion as a community of believers and to the continued role of the sacred and shared emotion/affect in social and political life. Specifically, it examines how modern communities (such as nations) remain constituted by a shared faith in conceptions of the sacred and how the corresponding sense of moral order is central to the enduring pursuit of ontological security. Therefore, it argues that international relations should focus on the perennial struggles over what communities hold sacred and that we can better understand the propensity for (“religious” or “secular”) violence by examining the continual interplay between the sacred, ontological security, and the hermeneutics of morality—with the so-called WoR being the locus classicus of this argument. Historical studies exploring how participants in the WoR navigated such struggles over the sacred thus allow us to explore these dynamics and further conceptualize our understanding of the sacred within modern “secular” politics. The article concludes by examining how the prospect for violence is interrelated with the perennial struggles over the sacred within, and between, political orders—a sentiment that brings into relief some of the hazards accompanying growing intrastate moral polarization and interstate ideological rivalry.
Kinematics Along the Qingchuan Fault and Deformation Pattern in the Eastern Tibetan Plateau
Authors: Sun Haoyue , He Honglin , Ikeda Yasutaka , Kano Ken'ichi , Gao Wei , Sun Wen , Shi Feng , Su Peng , Echigo Tomoo , Okada Shinsuke , Shirahama Yoshiki 
Published: August 2024

AbstractThe accommodation of the substantial eastward crustal motion of the Bayan Har block characterizes the dynamics of faults located at the eastern Tibetan Plateau. However, uncertainties persist concerning the manner and amount of deformation distributed on these faults, with slip senses and rates constituting critical factors. In the northeastern segment of the Longmenshan thrust zone, the contentious activity and the unknown geologic slip rate present challenges. This study, focusing on the Qingchuan fault, the predominant fault within the northeastern Longmenshan, employed satellite imagery interpretation, displaced fluvial terraces surveying, displacement measurements, and chronological analysis to comprehensively characterize its fault activity. Our investigation robustly demonstrates the Qingchuan fault has been active since the late Quaternary, and is primarily marked with a pronounced dextral slip at a rate of 0.6–1.0 mm/year. By quantitatively assessing the deformation rates of the faults at the eastern Tibetan Plateau, we propose that they sufficiently accommodate the entire eastward crustal movement of the Bayan Har block; thereby no additional deformation propagates beyond the Qingchuan fault. Furthermore, we introduce a subblock model to elucidate the regional crustal deformation pattern, wherein the eastward movement of the Bayan Har block transfers to the northeastward movement of the Bikou subblock. This movement results in reverse slip patterns for the Minjiang and Huya faults, while the Beichuan and Qingchuan faults predominantly experience dextral displacements. The complex strain partitioning within the northern Longmenshan range underscores the observed variations in slip patterns across different segments of the Longmenshan thrust zone, advancing our understanding of fault behavior and the orchestration of crustal deformation in this intricate tectonic framework.
Understanding Climate Change and Anthropogenic Impacts on the Salinization of Low‐Lying Coastal Groundwater Systems
Authors: Seibert Stephan L. , Greskowiak Janek , Oude Essink Gualbert H. P. , Massmann Gudrun 
Published: August 2024

AbstractFresh coastal groundwater is a valuable water resource of global significance, but its quality is threatened by saltwater intrusion. Excessive groundwater abstraction, sea‐level rise (SLR), land subsidence and other climate‐related factors are expected to accelerate this process in the future. The objective of this study is to (a) quantify the impact of projected climate change and (b) explore the role of individual hydrogeological boundaries on groundwater salinization of low‐lying coastal groundwater systems until 2100 CE. We employ numerical density‐dependent groundwater flow and salt transport modeling for this purpose, using Northwestern Germany as a case. Separate model variants are constructed and forced with climate data, that is, projected SLR and groundwater recharge, as well as likely ranges of other hydrogeological boundaries, including land subsidence, abstraction rates and drain levels. We find that autonomous salinization in the marsh areas, resulting from non‐equilibrium of the present‐day groundwater salinity distribution with current boundary conditions, is responsible for >50% of the salinization increase until 2100 CE. Sea‐level rise, land subsidence and drain levels are the other major factors controlling salinization. We further show that salinization of the water resources is a potential threat to coastal water users, including water suppliers and the agrarian sector, as well as coastal ecosystems. Regional‐scale uplifting of drain levels is identified as an efficient measure to mitigate salinization of deep and shallow groundwater in the future. The presented modeling approach highlights the consequences of climate change and anthropogenic impacts for coastal salinization, supporting the timely development of mitigation strategies.
Distinct Changes in the Influence of North Tropical Atlantic SST on ENSO Under Greenhouse Warming: A Comparison of CMIP5 and CMIP6
Authors: Kim Ji‐Gwang , Jo Hyun‐Su , Ham Yoo‐Geun , Park Jae‐Heung 
Published: August 2024

AbstractSea surface temperature (SST) anomalies over the North Tropical Atlantic (NTA) during the early boreal spring can trigger El Niño‐Southern Oscillation (ENSO) events in the following boreal winter. However, the future changes in the impact of the NTA on ENSO remain controversial. Here, we show distinct changes in the strength of the NTA−ENSO relationship due to global warming by comparing models from the Coupled Model Intercomparison Project (CMIP) 5 and CMIP6. The impact of the NTA on ENSO under greenhouse warming is notably enhanced in CMIP6 compared to CMIP5. A wetter mean state over the subtropical eastern North Pacific and increased oceanic sensitivity over the equatorial central Pacific are key factors that enhance the impact of the NTA SST on ENSO. Therefore, differences in the mean state under greenhouse warming between the CMIP5 and CMIP6 models can modulate the strength of the NTA−ENSO relationship.
Evolution Characteristics of Convective Clouds With Relatively Small Scales Over South China
Authors: Yang Yikun , Zhao Chuanfeng , Wang Yang , Sun Yue , Fan Hao , Zhao Xin , Zhou Yue 
Published: August 2024

AbstractAs a crucial element in the Earth's system, development of convective clouds is still insufficiently understood and simulated in both weather and climate models, particularly for small‐scale regional convective clouds. In this study, a series of convective clouds cases with relatively small scales are selected over south China, and the evolution characteristics of those convective clouds are investigated using high spatiotemporal resolution geostationary satellite data. Statistical results show that the shorter the life cycle or the smaller the area, the higher the proportion of convective clouds. Notably, approximately 79.23% of convective clouds have a life cycle of less than 3 hr, and 63.81% have an area of less than 500 km2 for selected cases. In addition, there are significant differences in the cloud characteristics and meteorological parameters during various convective cloud stages and durations. Nevertheless, the relative proportions of convective clouds at three identified stages remain relatively constant with almost no dependence on duration of convective clouds, which are 33.50%, 23.92%, and 42.58% for the developing, mature, and dissipation stages, respectively. In addition, we find that the cloud‐top cooling rate during the developing stage also affects the characteristics of the later stage of convective clouds. Quantitatively, the average cloud area and duration changed by 157.03 km2 and 0.17 hr when the cloud‐top cooling rate varies by 15 K/h.
How Does Regional Convection‐Permitting Modeling Improve the Simulation of the Atmospheric Water Cycle in Spring Over the Tibetan Plateau?
Authors: Zou Liwei , Zhou Tianjun , Zhao Yin 
Published: August 2024

AbstractThe Tibetan Plateau (TP) provides vital water resources for downstream regions, with spring precipitation contributing considerably to the annual totals over the southeastern TP. The added value of convection‐permitting modeling in simulating the spring climate over the TP is uncertain. Here, we conducted and compared decade‐long regional convection‐permitting (3.3 km) and convection‐parameterized (13.2 km) Icosahedral Nonhydrostatic Weather and Climate Model (ICON) simulations to reproduce the atmospheric water cycle in spring over the TP. Results indicated that 3.3 km mesh ICON (ICON_3.3 km) exhibited notable added value in simulating the spring atmospheric water cycle over the TP. ICON_3.3 km reduced the wet biases of precipitation in the ERA5 reanalysis and 13.2 km mesh ICON (ICON_13.2 km) simulations, and improved the simulation of surface evaporation over the central and eastern TP. The reduction in the simulated precipitation in ICON_3.3 km was primarily followed by a decrease in surface evaporation from March to May, second by a reduction in water vapor flux convergence in May due to decreased water vapor inflow from the southeastern TP. Furthermore, compared to ICON_13.2 km, ICON_3.3 km alleviated the “drizzling” bias, leading to drier surface soils and decreased evaporation, and lead to 3% decrease in the fraction of evaporation converted into precipitation. Sensitivity experiments conducted at resolution of 13.2 km but turning off the convection parameterization demonstrated that both explicit representation of convection and enhanced horizontal resolution were crucial for accurately representing the spring atmospheric water cycle over the TP. Our results highlighted the need to develop kilometer‐scale models for successfully reproducing the climate characteristics across the TP.
The Role of Lower Crustal Rheology on Surface Deformation During Oblique Extension: Insights From Sandbox Modeling
Authors: Mao Yuqiong , Li Yiquan , Jia Dong , Wang Xianyan , Chen Yingying , Li Qin , Li Rui 
Published: August 2024

AbstractExtensive researches have been conducted on the relationship between surface deformation and the properties of upper crust. However, the link between surface deformation and lower crustal rheology, especially in a three‐dimensional context, remains unclear. In this study, we utilize sandbox modeling to investigate the impact of lower crustal rheology on surface deformation during oblique extension. Under the same conditions, six models with different lower crustal viscosities, both with and without syn‐kinematic deposits, are conducted. The results indicate that a decrease in lower crustal viscosity may contribute to an increase in: (a) graben width, (b) graben length, (c) graben spacing, (d) the number of isolated rifts and (e) topographic relief of oblique extensional systems, while also leading to a reduction in the total number of grabens. Notably, there exists a negative linear correlation between graben spacing and lower crustal viscosity. In map view, the angle between fault strike and the direction of pre‐existing discontinuities increases as the viscosity of the lower crust decreases. Furthermore, the frequency of large rakes (>50°) decreases with decreasing lower crustal viscosity. These findings align with natural examples such as the East African Rift System, Weihe Graben and the South Tibetan Rift in terms of geomorphology, tectonics, and crustal rheology. Through a comprehensive comparison of the graben width, spacing, and the angle between fault strike and the direction of pre‐existing discontinuities, our study provides valuable insights into the rheology of the lower crust in natural settings.
Nicotine reduces discrimination between threat and safety in the hippocampus, nucleus accumbens and amygdala
Authors: Mueller Madeleine , Fadai Tahmine , Rauh Jonas , Haaker Jan 
Published: August 2024

AbstractNicotine intake is linked to the maintenance and development of anxiety disorders and impairs adaptive discrimination of threat and safety in rodents and humans. Yet, it is unclear if nicotine exerts a causal pharmacological effect on the affective and neural mechanisms that underlie aversive learning. We conducted a pre-registered, pseudo-randomly and double-blinded pharmacological fMRI study to investigate the effect of acute nicotine on Fear Acquisition and Extinction in non-smokers (n = 88). Our results show that nicotine administration led to decreased discrimination between threat and safety in subjective fear. Nicotine furthermore decreased differential (threat vs. safety) activation in the hippocampus, which was functionally coupled with Nucleus Accumbens and amygdala, compared to placebo controls. Additionally, nicotine led to enhanced physiological arousal to learned threats and overactivation of the ventral tegmental area. This study provides mechanistic evidence that single doses of nicotine impair neural substrates of adaptive aversive learning in line with the risk for the development of pathological anxiety.
Ferroptosis and inflammation are modulated by the NFIL3-ACSL4 axis in sepsis associated-acute kidney injury
Authors: Xiao Zhong , Zhang Jie , Qiu Zhimin , Liu Hongbing , Ding Hua , Li Hi , Liu Yuanxin , Zou Xiaohua , Long Juan 
Published: August 2024

AbstractSepsis-associated acute kidney injury (SA-AKI) increases the risk of death in patients with sepsis, and its major pathological change is the death of renal tubular cells. However, the mechanism of its occurrence remains unclear. Sepsis can lead to circadian dysregulation, and the rhythm gene NFIL3 has been reported to regulate lipid metabolism. There is compelling evidence that has demonstrated that lipid peroxidation can cause cellular ferroptosis. In this study, we established the in vitro and in vivo models of SA-AKI and confirmed the presence of ferroptosis of the renal tubular epithelial cells in SA-AKI. In addition, analysis of the GEO database showed that NFIL3 was highly expressed in sepsis patients and was highly correlated with the key molecule of ferroptosis, ACSL4. The in vitro and in vivo data suggested that NFIL3 was involved in ferroptosis and inflammation in SA-AKI. Subsequently, loss-of-function experiments revealed that NFIL3 knockdown attenuated ferroptosis and inflammation in renal tubular epithelial cells by downregulating ACSL4 expression, thus protecting SA-AKI. In conclusion, this study is the first to illustrate the involvement of the rhythm gene NFIL3 in SA-AKI, providing new insights and potential therapeutic targets for SA-AKI.
HDAC3 genetic and pharmacologic inhibition radiosensitizes fusion positive rhabdomyosarcoma by promoting DNA double-strand breaks
Authors: Cassandri Matteo , Porrazzo Antonella , Pomella Silvia , Noce Beatrice , Zwergel Clemens , Aiello Francesca Antonella , Vulcano Francesca , Milazzo Luisa , Camero Simona , Pajalunga Deborah , Spada Massimo , Manzi Valeria , Gravina Giovanni Luca , Codenotti Silvia , Piccione Michela , Tomaciello Miriam , Signore Michele , Barillari Giovanni , Marchese Cinzia , Fanzani Alessandro , De Angelis Biagio , Quintarelli Concetta , Vakoc Christopher R. , Chen Eleanor Y. , Megiorni Francesca , Locatelli Franco , Valente Sergio , Mai Antonello , Rota Rossella , Marampon Francesco 
Published: August 2024

AbstractRadiotherapy (RT) plays a critical role in the management of rhabdomyosarcoma (RMS), the prevalent soft tissue sarcoma in childhood. The high risk PAX3-FOXO1 fusion-positive subtype (FP-RMS) is often resistant to RT. We have recently demonstrated that inhibition of class-I histone deacetylases (HDACs) radiosensitizes FP-RMS both in vitro and in vivo. However, HDAC inhibitors exhibited limited success on solid tumors in human clinical trials, at least in part due to the presence of off-target effects. Hence, identifying specific HDAC isoforms that can be targeted to radiosensitize FP-RMS is imperative. We, here, found that only HDAC3 silencing, among all class-I HDACs screened by siRNA, radiosensitizes FP-RMS cells by inhibiting colony formation. Thus, we dissected the effects of HDAC3 depletion using CRISPR/Cas9-dependent HDAC3 knock-out (KO) in FP-RMS cells, which resulted in Endoplasmatic Reticulum Stress activation, ERK inactivation, PARP1- and caspase-dependent apoptosis and reduced stemness when combined with irradiation compared to single treatments. HDAC3 loss-of-function increased DNA damage in irradiated cells augmenting H2AX phosphorylation and DNA double-strand breaks (DSBs) and counteracting irradiation-dependent activation of ATM and DNA-Pkcs as well as Rad51 protein induction. Moreover, HDAC3 depletion hampers FP-RMS tumor growth in vivo and maximally inhibits the growth of irradiated tumors compared to single approaches. We, then, developed a new HDAC3 inhibitor, MC4448, which showed specific cell anti-tumor effects and mirrors the radiosensitizing effects of HDAC3 depletion in vitro synergizing with ERKs inhibition. Overall, our findings dissect the pro-survival role of HDAC3 in FP-RMS and suggest HDAC3 genetic or pharmacologic inhibition as a new promising strategy to overcome radioresistance in this tumor.
A testis-specific lncRNA functions as a post-transcriptional regulator of MDM2 and stimulates apoptosis of testicular germ cell tumor cells
Authors: Ito Saya , Ueno Akihisa , Ueda Takashi , Ogura Ryota , Sako Satoshi , Gabata Yusuke , Murashita Junki , Takahashi Hikaru , Ukimura Osamu 
Published: August 2024

AbstractGerm cells preferentially induce apoptosis in response to DNA damage to avoid genomic mutations. Apoptosis of germ cells is closely related to cancer development and chemotherapy resistance; however, its regulatory mechanism is unclear. Here, we suggest that testis-specific lncRNA LINC03074 is involved in male germ cell apoptosis by regulating the expression of the proto-oncogene MDM2. LINC03074 is highly expressed in the sperm of healthy adult testes and cancer cells of testes with testicular germ cell tumors (TGCTs). LINC03074 binds to MDM2 mRNA via an Alu element, thereby reducing MDM2 protein levels. LINC03074 stimulates STAU1-mediated nuclear export of MDM2 mRNA by increasing STAU1 binding to MDM2 mRNA in the cell nucleus, thereby promoting PKR-mediated translational repression in the cytoplasm. The induction of apoptosis in TGCT cells and their responsiveness to the anticancer drug cisplatin is enhanced by LINC03074. Notably, LINC03074 increased E2F1 expression without increasing p53, the primary target of MDM2, and upregulated the apoptotic gene p73, the target gene of E2F1. LINC03074-mediated regulation of apoptosis contributes to the responsiveness of TGCTs to anticancer drug-induced DNA damage.
The evolution of democratic peace in animal societies
Authors: Hunt K. L. , Patel M. , Croft D. P. , Franks D. W. , Green P. A. , Thompson F. J. , Johnstone R. A. , Cant M. A. , Sankey D. W. E. 
Published: August 2024

AbstractA major goal in evolutionary biology is to elucidate common principles that drive human and other animal societies to adopt either a warlike or peaceful nature. One proposed explanation for the variation in aggression between human societies is the democratic peace hypothesis. According to this theory, autocracies are more warlike than democracies because autocratic leaders can pursue fights for private gain. However, autocratic and democratic decision-making processes are not unique to humans and are widely observed across a diverse range of non-human animal societies. We use evolutionary game theory to evaluate whether the logic of democratic peace may apply across taxa; specifically adapting the classic Hawk-Dove model to consider conflict decisions made by groups rather than individuals. We find support for the democratic peace hypothesis without mechanisms involving complex human institutions and discuss how these findings might be relevant to non-human animal societies. We suggest that the degree to which collective decisions are shared may explain variation in the intensity of intergroup conflict in nature.
Stability of ecologically scaffolded traits during evolutionary transitions in individuality
Authors: Doulcier Guilhem , Takacs Peter , Hammerschmidt Katrin , Bourrat Pierrick 
Published: August 2024

AbstractEvolutionary transitions in individuality are events in the history of life leading to the emergence of new levels of individuality. Recent studies have described an ecological scaffolding scenario of such transitions focused on the evolutionary consequences of an externally imposed renewing meta-population structure with limited dispersal. One difficulty for such a scenario has been explaining the stability of collective-level traits when scaffolding conditions no longer apply. Here, we show that the stability of scaffolded traits can rely on evolutionary hysteresis: even if the environment is reverted to an ancestral state, collectives do not return to ancestral phenotypes. We describe this phenomenon using a stochastic meta-population model and adaptive dynamics. Further, we show that ecological scaffolding may be limited to Goldilocks zones of the environment. We conjecture that Goldilocks zones—even if they might be rare—could act as initiators of evolutionary transitions and help to explain the near ubiquity of collective-level individuality.
Projected rapid response of stratospheric temperature to stringent climate mitigation
Authors: Romanzini-Bezerra Grasiele , Maycock Amanda C. 
Published: August 2024

AbstractDeep, rapid and sustained reductions in greenhouse gas emissions are required to meet the 2015 Paris Agreement climate target. If the world strengthens efforts toward near-term decarbonisation and undertakes major societal transformation, this will be met with requests from policymakers and the public for evidence that our actions are working and there are demonstrable effects on the climate system. Global surface temperature exhibits large internal variability on interannual to decadal timescales, meaning a reduction in the magnitude of surface warming would not be robustly attributable to climate mitigation for some time. In contrast, global stratospheric temperature trends have much higher signal-to-noise ratios and could offer an early indication of the effects of climate mitigation. Here we examine projected near-term global temperature trends at the surface and in the stratosphere using large ensemble climate models following three future emission scenarios. Under rapid, deep emission cuts following SSP1–1.9, modelled middle and upper stratospheric cooling trends show a detectable weakening within 5 years compared to a scenario approximately representing current climate commitments (SSP2–4.5). Therefore, stratospheric temperature trends could serve as an early indicator to policymakers and the public that climate mitigation is taking effect.