bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring and modelling the hydro-morphological landscape of a Himalayan basin: a geospatial study of Nandakini Basin in Uttarakhand, India
Authors: Ganie Parvaiz Ahmad , Posti Ravindra , Pandey Pramod Kumar 
Published: July 2024

AbstractThis study comprehensively examines the hydro-morphological, topo-hydrological, and physiographic features of the Nandakini catchment in the north-western Himalayas. In the absence of extensive hydrological data, employing morphometric parameters proves to be a crucial and efficient approach for delineating geological structures and assessing hydrodynamic activity in the river basin. Utilizing SRTM DEM, SOI toposheets, and GIS, the study identified twenty watersheds within the catchment, estimating its total area at 540.98 km2. The analysis revealed a 6th-order catchment with a primarily sub-dendritic to dendritic drainage pattern, susceptible to flooding and gully erosion from slow surface runoff. The elongated shape and compactness coefficient indicated delayed peak runoff. Coarse drainage texture and high relief ratio suggested increased vulnerability to erosion. Physiographic indices indicated a later youth stage of basin development, while topo-hydrological indices highlighted significant topographic and spatial variability in water availability, emphasizing erosion potential. This study provides valuable insights for developing sustainable catchment management plans and informing decision-making in water resources management for the Nandakini catchment.
Assessing adherence to plant-rich dietary patterns using metabolic signatures of plant food metabolites
Authors: Li Y. , Xu Y. , Le Sayec M. , Spector T. D , Menni C. , Gibson R. , Rodriguez-Mateos A. 
Published: July 2024

Diet is an important modifiable lifestyle factor for human health, and plant-rich dietary patterns are associated with lower risk of non-communicable diseases in numerous studies. However, objective assessment of plant-rich dietary exposure in nutritional epidemiology studies remains challenging. This study aimed to develop and evaluate metabolic signatures of the most widely used plant-rich dietary patterns using a targeted metabolomics method comprising of 108 plant food metabolites.A total of 218 healthy participants from the POLYNTAKE cohort were included, aged 51.5 ± 17.7 years, with 24h urine samples measured using ultra-high-performance liquid chromatography–mass spectrometry. The validation dataset employed three sample types to test the robustness of the signature, including 24h urine (ABP cohort, n = 88), plasma (POLYNTAKE cohort, n = 195), and spot urine (TwinsUK cohort, n = 198). Adherence to the plant-rich diet was assessed using a priori plant- rich dietary patterns. A combination of metabolites that evaluates the adherence and metabolic response to a specific diet was identified as metabolic signature. We applied linear regression analysis to select the metabolites significantly associated with dietary patterns (adjusting energy intake), and ridge regression to estimate penalized weights of each candidate metabolite. The correlation between metabolic signature and the dietary pattern was assessed by Spearman analysis (FDR < 0.05).The metabolic signatures consisting of 42, 22, 35, 15, 33, and 33 predictive metabolites across different subclasses were found to be associated with adherence to Amended Mediterranean Score (A-MED), Original MED (O-MED), Dietary Approaches to Stop Hypertension (DASH), Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND), healthy Plant-based Diet Index (hPDI) and unhealthy PDI (uDPI), respectively. The overlapping and distinct predictive metabolites across six dietary patterns predominantly consisted of phenolic acids (n = 38), including 14 cinnamic acids, 14 hydroxybenzoic acids, seven phenylacetic acids, and three hippuric acids. Six metabolites were included in all signatures, including two lignans: enterolactone-glucuronide, enterolactone-sulfate, and four phenolic acids: cinnamic acid, cinnamic acid-4'-sulfate, 2'- hydroxycinnamic acid, and 4-methoxybenzoic acid-3-sulfate. The established signatures were robustly correlated with dietary patterns in validation dataset (r = 0.13 - 0.40, FDR < 0.05).We developed and evaluated a set of metabolic signatures that robustly reflected the adherence and metabolic response to plant-rich dietary patterns, suggesting the potential of these signatures to serve as an objective assessment of free-living eating habits.
Dietitians’ perspectives on clinical pathways and practice in relation to the dietary management of irritable bowel syndrome in the UK: A qualitative study
Authors: Belogianni K. , Khandige P. , Silverio S. , Windgassen S. , Moss-Morris R. , Lomer M.C.E 
Published: July 2024

Irritable bowel syndrome (IBS) is a chronic and relapsing gastrointestinal condition which negatively impacts quality of life(1). Dietary triggers are common and dietary management is central to the IBS treatment pathway with dietitians being the main education providers for patients(2). The aim of this study was to explore the perceptions of dietitians towards current practices in IBS services in clinical settings across the UK.Qualitative semi-structured interviews were undertaken to explore current practices, barriers, and facilitators to dietetic practice and expected treatment outcomes. Eligible participants were dietitians specialising in IBS and working in the National Health System (NHS) in the UK. Interviews were held virtually. Audio was recorded and transcribed following intelligent transcription. Data were analysed using template analysis (3).Thirteen dietitians (n=12 female) specialising in gastroenterology consented to participate in the study. Dietitians were working in various NHS Trusts across the country (Southeast England n=3; Southwest England n=3; Northwest England n=2; Northeast England n=1; West Midlands n=1; Southwest Wales n=1 and Southcentral Scotland n=2). Ten out of 13 dietitians had more than five years of experience in IBS management. Three main themes emerged: 1) Dietetic services as part of IBS referral pathways; 2) Practices in relation to dietetic services and 3) Implications of services on patients’ expectations and feelings. Each main theme had subthemes to facilitate the description and interpretation of data. The increasing number of IBS referrals to dietitians and the need for accurate and timely IBS diagnosis and specialist IBS dietitians was reported, alongside the use of digital innovation to facilitate practice and access to dietetic care. The use of Internet as a source of (mis)information by patients and the limited time available for educating patients were identified as potential barriers to dietetic practice. Dietitians follow a patient-centred approach to dietary counselling and recognise the negative implications of perceived IBS-related stigma by patients on their feelings and treatment expectations.The study identified areas and practices which can facilitate access to dietetic services and patient- centred care in IBS management as outlined in guidelines (4).
Characterising dietary protein intake in Irish adults on the island of Ireland
Authors: Griffin H. , Nugent A.P , McNulty B. A , Wright D. , Brennan L. 
Published: July 2024

Shifting dietary protein intakes from animal to plant-based sources is suggested as a path to sustain the world’s food consumption and maintain planetary resources (1). However, to facilitate change, it is important to characterise baseline dietary protein patterns. This study aimed to examine dietary protein intakes on the island of Ireland in order to determine population characteristics and food sources influencing protein intake.Analyses were performed on the Northern Ireland sub cohort of the UK National Dietary Nutrition Survey (NDNS 2016-2019) (2) and the Irish National Adult Nutrition Survey (2008-2010) (3). Both surveys used a four-day food diary and a final sample of 1484 adults, aged 18-64 years was extracted (NANS; n =1274 and NI NDNS; n=210). Mean daily intakes for protein (MDI; % total energy, TE) for the total population were calculated and the population was divided into three tertile groups based on low, medium and high protein intake (%TE). Differences in population characteristics, energy MDI, key nutrients (%TE or per 10MJ) and contributing food sources were examined across these tertiles, using chi-square and one-way ANOVA with covariates (age and BMI) and correcting for multiple comparisons as appropriate (P<0.005).Overall, 17.1% of TE was obtained from protein and 77% of participants met their protein DRV based on EFSA recommendations of 0.83g/kg/body weight (4). The difference in protein intakes between the highest and lowest tertiles was 7.8% TE (21.2 % TE vs 13.4% TE) with high protein consumers reporting lower energy intakes (1734 ± 564kcal) compared to low consumers (2185 ± 661 kcal). High protein consumers were older (42.5 ± 12.8 years) and had a higher BMI (27.7 ± 6.0 kg/m2). They also had higher MDI of dietary fibre, calcium, zinc, sodium, iron, folate and vitamins A, C, D and B12 (per 10MJ) (p<0.001) and lower MDI of carbohydrates, fat, saturated fat (%TE) in comparison to low consumers (p<0.001). The % contribution of ‘chicken, turkey and dishes’ (18.3%), ‘beef, veal and dishes’ (12.8%) and ‘fish and fish products (7.0%) to protein intakes were significantly higher in the high versus the low consumption group (10%, 7.4%, 4.4% TE respectively; P<0.001). In contrast, those in the lowest protein intake group had a significantly higher intakes of protein coming from dietary sources including ‘burgers, sausages and meat products (9.9 vs 5.9%), ‘white bread and rolls’ (6.9 vs 3.9%), ‘potatoes (including chips)’ (4.1 vs 2.9 %) and ‘cakes, pastries, buns and fruit pies’ (1.7 vs 0.8%) compared to high consumers.In general, animal protein sources contributed more to total daily protein intakes than plant sources, however, the pattern of protein foods differed according to level of protein intake. These findings will aid in the development of strategies to diversify protein intakes on the Island of Ireland.
Effect of vitamin D2 supplementation on 25-hydroxyvitamin D3 status: a systematic review and meta-analysis of randomised controlled trials
Authors: Brown E.I.G. , Darling A.L. , Robertson T.M. , Hart K.H. , Lanham-New S.A. , Elliott R.M. , Warren M.J. 
Published: July 2024

There are known differences in biological functionality between vitamin D2 and D3. It is suspected from randomised control trial (RCT) data that vitamin D2 supplementation causes a reduction in serum 25-hydroxyvitamin D3 (25(OH)D3) concentrations (1), but the size of the effect has yet to be fully assessed across multiple studies. The aim of this study was to undertake a systematic review and meta-analysis of the effect of vitamin D2 supplementation on serum 25(OH)D3 concentrations.PUBMED was searched for publications from 1st January 1975 to 1st February 2023. Of the 182 papers retrieved, 29 were included in the systematic review, and of those, 18 were suitable for meta-analysis.The meta-analysis found significant reductions in serum D3 after vitamin D2 supplementation compared with control, for both end of trial between groups data (weighted mean difference (WMD) (random) = −13.51 nmol/L; 95% CI: −20.14, −6.89; P < 0.0001) and absolute change over the trial (WMD (random) = −9.25 nmol/L; 95% CI: −14.40, −4.10; P = 0.0004). Similar results were found when D2 supplementation was compared to D3 supplementation, although as expected, the magnitude of the difference was larger, with WMD (random) = −46.20 nmol/L (95% CI: −60.80, −31.60; P < 0.00001) for end of trial data, and WMD (random) = −56.23 nmol/L (95% CI: -69.17, −43.28; P < 0.00001) for absolute change.Overall, we found that vitamin D2 supplementation produces significant reductions in serum 25(OH)D3 concentrations, when compared to either control or vitamin D3 supplementation. An inverse relationship between vitamin D2 and D3 concentrations has been proposed in the literature (2). A regulatory mechanism that disposes of 25(OH)D after an increase in vitamin D concentrations could explain our results (3). Moreover, supplementation with vitamins D2 and D3 has differential effects on gene expression (4). However, longer-term research is needed to establish whether clinical advice should recommend vitamin D3 supplements over vitamin D2 supplements, where appropriate.
Towards a model of playful music learning for primary classrooms: recommendations based on a review of literature
Authors: Byrne Rachael , Murphy Regina , Ward Francis , McCabe Una 
Published: July 2024

AbstractPlayful practices have been linked to increased motivation, engagement, learning and skill development. However, limited research has explored what playful music learning might look like for primary schools, and how teachers might incorporate a range of playful music practices within their classrooms. Our conceptual model for playful music learning amalgamates and builds upon previous philosophy, theory and research in the education and music education spheres. In doing so, it extends musical play across a continuum of ownership as has been proposed by Zosh et al. (2017) in the realm of playful learning more generally. Playful elements associated with the work of music education pedagogues Kodály and Kokas and other researchers in the field are outlined. Examples of musical games-play and guided musical play for primary classrooms are illustrated, and some recommendations are provided to support teachers in facilitating increasingly playful music learning.
Sleep as a driver of pre- and postnatal brain development
Authors: de Groot Eline R. , Dudink Jeroen , Austin Topun 
Published: July 2024

Abstract
In 1966, Howard Roffwarg proposed the ontogenic sleep hypothesis, relating neural plasticity and development to rapid eye movement (REM) sleep, a hypothesis that current fetal and neonatal sleep research is still exploring. Recently, technological advances have enabled researchers to automatically quantify neonatal sleep architecture, which has caused a resurgence of research in this field as attempts are made to further elucidate the important role of sleep in pre- and postnatal brain development. This article will review our current understanding of the role of sleep as a driver of brain development and identify possible areas for future research.

Impact

The evidence to date suggests that Roffwarg’s ontogenesis hypothesis of sleep and brain development is correct.

A better understanding of the relationship between sleep and the development of functional connectivity is needed.

Reliable, non-invasive tools to assess sleep in the NICU and at home need to be tested in a real-world environment and the best way to promote healthy sleep needs to be understood before clinical trials promoting and optimizing sleep quality in neonates could be undertaken.
G protein-coupled receptor kinases in hypertension: physiology, pathogenesis, and therapeutic targets
Authors: Zhang Fuwei , Armando Ines , Jose Pedro A. , Zeng Chunyu , Yang Jian 
Published: July 2024

AbstractG protein-coupled receptors (GPCRs) mediate cellular responses to a myriad of hormones and neurotransmitters that play vital roles in the regulation of physiological processes such as blood pressure. In organs such as the artery and kidney, hormones or neurotransmitters, such as angiotensin II (Ang II), dopamine, epinephrine, and norepinephrine exert their functions via their receptors, with the ultimate effect of keeping normal vascular reactivity, normal body sodium, and normal blood pressure. GPCR kinases (GRKs) exert their biological functions, by mediating the regulation of agonist-occupied GPCRs, non-GPCRs, or non-receptor substrates. In particular, increasing number of studies show that aberrant expression and activity of GRKs in the cardiovascular system and kidney inhibit or stimulate GPCRs (e.g., dopamine receptors, Ang II receptors, and α- and β-adrenergic receptors), resulting in hypertension. Current studies focus on the effect of selective GRK inhibitors in cardiovascular diseases, including hypertension. Moreover, genetic studies show that GRK gene variants are associated with essential hypertension, blood pressure response to antihypertensive medicines, and adverse cardiovascular outcomes of antihypertensive treatment. In this review, we present a comprehensive overview of GRK-mediated regulation of blood pressure, role of GRKs in the pathogenesis of hypertension, and highlight potential strategies for the treatment of hypertension.
Comparative analysis of F-18 FDG PET/CT images between scrub typhus and systemic lupus erythematosus
Authors: Han Yeon-Hee , Hwang Joo-Hee , Choi Yunjung , Lee Chang-Seop 
Published: July 2024

AbstractThis study evaluated the use of F-18 fluorodeoxyglucose (FDG) PET/CT imaging to differentiate between scrub typhus and systemic lupus erythematosus (SLE) in patients presenting with lymphadenopathy. We carried out a retrospective analysis of 18 scrub typhus patients and seven SLE patients, using various imaging parameters, including lymph node size, spleen and liver lengths, the distance between the two farthest lesions (Dmax), and assessments of glucose metabolism. On FDG PET images, we measured the maximum standardized uptake value (SUVmax) of the lymph nodes, spleen, and liver and the mean standardized uptake value (SUVmean) of the liver and spleen. The Dmax values of scrub typhus patients were significantly longer than those of SLE patients, indicating that lymphadenopathy is more generalized in the patients with scrub typhus. The SUVmax values for the lymph node, spleen, and liver were also higher in patients with scrub typhus, while the SUVmean of the liver and spleen did not differ between the two groups. This study is the first to compare FDG PET/CT images between these two conditions, suggesting the potential of this imaging modality to provide critical diagnostic distinctions.
Dynamic examination of closed cylindrical shells utilizing the differential transform method
Authors: Khosravi Amir Esmaeel , Shahabian Farzad , Aftabi Sani Ahmad 
Published: July 2024

AbstractThis article presents an innovative approach using the Differential Transform Method (DTM) to analyze the vibration characteristics of cylindrical shells, integrating Taylor's series with Sander's classical theory. It demonstrates DTM's efficiency, accuracy, and potential as an alternative method. The study introduces a novel application of the DTM in exploring the free vibration of cylindrical shells, detailing a technique to address challenges such as normalization, linear solution methodologies, and parameter derivative modifications. A dimensionless parameter analysis evaluates the impact of length, radius, thickness, and modulus of elasticity. Comparative analysis with Hybrid Finite Element Method (FEM) data and validation against existing literature highlights DTM's precision and reliability. In conclusion, DTM offers a robust solution for the eigenvalue problem in coupled differential equations, providing accurate vibration parameters. Additionally, an important relationship between the modulus of elasticity and frequency in the dimensionless state was obtained.
Data-driven prediction on critical mechanical properties of engineered cementitious composites based on machine learning
Authors: Qing Shuangquan , Li Chuanxi 
Published: July 2024

AbstractThe present study introduces a novel approach utilizing machine learning techniques to predict the crucial mechanical properties of engineered cementitious composites (ECCs), spanning from typical to exceptionally high strength levels. These properties, including compressive strength, flexural strength, tensile strength, and tensile strain capacity, can not only be predicted but also precisely estimated. The investigation encompassed a meticulous compilation and examination of 1532 datasets sourced from pertinent research. Four machine learning algorithms, linear regression (LR), K nearest neighbors (KNN), random forest (RF), and extreme gradient boosting (XGB), were used to establish the prediction model of ECC mechanical properties and determine the optimal model. The optimal model was utilized to employ SHapley Additive exPlanations (SHAP) for scrutinizing feature importance and conducting an in-depth parametric analysis. Subsequently, a comprehensive control strategy was devised for ECC mechanical properties. This strategy can provide actionable guidance for ECC design, equipping engineers and professionals in civil engineering and material science to make informed decisions throughout their design endeavors. The results show that the RF model demonstrated the highest prediction accuracy for compressive strength and flexural strength, with R2 values of 0.92 and 0.91 on the test set. The XGB model outperformed in predicting tensile strength and tensile strain capacity, with R2 values of 0.87 and 0.80 on the test set, respectively. The prediction of tensile strain capacity was the least accurate. Meanwhile, the MAE of the tensile strain capacity was a mere 0.84%, smaller than the variability (1.77%) of the test results in previous research. Compressive strength and tensile strength demonstrated high sensitivity to variations in both water-cement ratio (W) and water reducer (WR). In contrast, flexural strength exhibited high sensitivity solely to changes in W. Conversely, the sensitivity of tensile strain capacity to input features was moderate and consistent. The mechanical attributes of ECC emerged from the combined effects of multiple positive and negative features. Notably, WR exerted the most significant influence on compressive strength among all features, whereas polyethylene (PE) fiber emerged as the primary driver affecting flexural strength, tensile strength, and tensile strain capacity.
Biparatopic anti-PCSK9 antibody enhances the LDL-uptake in HepG2 cells
Authors: Li Xinyang , Zhang Wei , Shu Yu , Huo Rui , Zheng Chengyang , Qi Qi , Fu Pengfei , Sun Jie , Wang Yuhuan , Wang Yan , Lu Juxu , Zhao Xiangjie , Yin Guoyou , Wang Qingqing , Hong Jun 
Published: July 2024

AbstractProprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target to reduce lipids. In 2020, we reported a chimeric camelid-human heavy chain antibody VHH-B11-Fc targeting PCSK9. Recently, it was verified that VHH-B11 binds one linear epitope in the PCSK9 hinge region. To enhance its druggability, we have developed a novel biparatopic B11-H2-Fc Ab herein. Thereinto, surface plasmon resonance (SPR) confirmed the epitope differences in binding-PCSK9 among VHH-B11, VHH-H2 and the approved Repatha. Additionally, SPR revealed the B11-H2-Fc exhibits an avidity of approximately 0.036 nM for PCSK9, representing a considerable increase compared to VHH-B11-Fc (~ 0.69 nM). Moreover, we found the Repatha and B11-H2-Fc exhibited > 95% PCSK9 inhibition efficiency compared to approximately 48% for the VHH-Fc at 7.4 nM (P < 0.0005). Further, we verified its biological activity using the human hepatoma cells G2 model, where the B11-H2-Fc exhibited almost 100% efficiency in PCSK9 inhibition at only 0.75 μM. The immunoblotting results of low-density lipoprotein cholesterol (LDL-c) uptake assay also demonstrated the excellent performance of B11-H2-Fc on recovering the LDL-c receptor (LDLR), as strong as the Repatha (P > 0.05). These findings provide the first evidence of the efficacy of a novel Ab targeting PCSK9 in the field of lipid-lowering drugs.