bluuebunny/crossref_metadata_2025_split huggingface dataset:
Considerations for kelp aquaculture on South Africa’s west coast: geospatial analysis and research implications
Authors: Lück-Vogel Melanie , Bolton John J. , Rothman Mark D. , Bernatzeder Andrea , Macey Brett M. , Cyrus Mark D. , Arendse Dale C. Z. , Pillay Parsuramen J. , Brown-Webb Bernadette 
Published: August 2024

Abstract
The commercial use of kelp continues to gain interest worldwide. While in some East Asian countries kelp farming has a long history, the kelp industry in South Africa is based on harvesting of kelp from natural kelp forests or by beach-cast collection. This study examined the potential for kelp aquaculture on South Africa’s west coast, focusing on the three indigenous species of kelp, Ecklonia maxima, Laminaria pallida and Macrocystis pyrifera. Geospatial analysis was used to identify and assess nine potentially suitable areas for kelp farming, based on natural habitat conditions, and examination of potential conflicts with other users and enabling land-use factors. An assessment of the market, technical and financial aspects of a kelp farming opportunity indicated that a 4 ha kelp farm, with longlines producing 750 to 1,000 t of fresh kelp per annum, could be viable as an integrated aquaculture activity adjacent to an existing mussel or oyster farm. We recommend a detailed feasibility study for kelp aquaculture in South Africa, with market and technical research, and financial modelling. Current seaweed industry legislation is mostly concerned with the wild resource, and there is a need for specific policies relating to seaweed aquaculture to facilitate growth of the industry.
Reducing sludge formation by enhancing biological decay of biomass: a mathematical model
Authors: Alsaeed Salman S. , Nelson Mark I. , Msmali Ahmed H. , Edwards Maureen 
Published: August 2024

Abstract
We investigate a model for an activated sludge process that contains a chemical reactor unit attached to a bioreactor. Inside the chemical reactor unit, a process takes place which increases the decay coefficient of heterotrophic biomass. This mimics a number of experimental techniques which are used to decrease the mass of sludge. Such techniques are of growing interest as the activated sludge process produces large volumes of sludge; the costs associated with its disposal are significant. Our primary interest is to investigate how the operation of the chemical reactor unit changes the steady-state concentrations of both the total suspended solids within the biological reactor and the chemical oxygen demand in the effluent stream. The operation of a chemical reactor unit always increases the value of chemical oxygen demand in the effluent stream. The behaviour of the total suspended solids is more complicated; in some cases, the operation of the CRU increases the total suspended solids. For a fixed value of the chemical oxygen demand in the influent stream, we show that both the percentage reduction in the total suspended solids and the chemical oxygen demand in the effluent stream are increasing functions of the soluble substrate in the feed. The same trends occur when the influent composition is fixed, and the disintegration rate inside the chemical reactor unit is increased. This leads to dichotomic behaviour, decreasing the total suspended solids increases the chemical oxygen demand in the effluent stream. There are two consequences of this behaviour. Firstly, there are some waste streams that can not be cleaned using the process configuration considered in this paper. Secondly, the imposition of a target value for the chemical oxygen demand in the effluent stream imposes a maximum achievable reduction in the total suspended solids in the biological reactor. Higher reductions can not be achieved without causing the chemical oxygen demand in the effluent stream to exceed the target value.
Effects of resveratrol on rheumatic symptoms and hepatic metabolism of arthritic rats
Authors: Simões Mellina S. , Souza Ana Beatriz P. , Silva-Comar Francielli M.S. , Bersani-Amado Ciomar A. , Cuman Roberto K.N. , Peralta Rosane M. , Sá-Nakanishi Anacharis B. , Bracht Lívia , Bracht Adelar , Comar Jurandir F. 
Published: August 2024

Abstract

Objectives
Resveratrol has been studied as a potential agent for treating rheumatic conditions; however, this compound suppresses glucose synthesis and glycogen catabolism when infused in perfused livers of both arthritic and healthy rats. This study investigated the effects of oral administration of resveratrol on inflammation and liver metabolism in rats with arthritis induced by Freund’s adjuvant, which serves as rheumatoid arthritis model.

Methods
Holtzman rats, both healthy and exhibiting arthritic symptoms, were orally treated with resveratrol at doses varying from 25 to 500 mg/kg for a 5-day period preceding arthritis induction, followed by an additional 20-day period thereafter. Paw edema, arthritic score and hepatic myeloperoxidase activity were assessed to evaluate inflammation. Glycogen catabolism and gluconeogenesis from lactate were respectively evaluated in perfused livers from fed and fasted rats.

Results
Resveratrol decreased the liver myeloperoxidase activity at doses above 100 mg/kg, and decreased the paw edema and delayed the arthritic score at doses above 250 mg/kg. The hepatic gluconeogenesis was decreased in arthritic rats and resveratrol did not improve it. However, resveratrol did not negatively modify the gluconeogenesis in livers of healthy and arthritic rats. Glycogen catabolism was in part and slightly modified by resveratrol in the liver of arthritic and healthy rats.

Conclusions
It is improbable that resveratrol negatively affects the liver metabolism, especially considering that gluconeogenesis is highly fragile to changes in cellular architecture. The findings suggest that resveratrol could serve as alternative for treating rheumatoid arthritis. Nevertheless, prudence is advised regarding its transient effects on liver metabolism.
Open Network for Digital Commerce in India: Past, Present, and Future
Authors: Islam Muhammad Idrees ul , Lone Umer Mushtaq , Bhat Irshad Ahmad , Aamir Sheikh , Salau Ayodeji Olalekan 
Published: August 2024

AbstractThe primary objective of this article is to provide a comprehensive analysis of the open network for digital commerce (ONDC), an innovative initiative by the Indian government. The study aims to explore the potential impact of ONDC on India’s digital commerce sector, focusing on how it seeks to democratize digital commerce and create an environment characterized by fair competition, innovation, and inclusivity. Our methodology involves an extensive review and thematic analysis of relevant literature. This approach includes a detailed examination of ONDC’s core objectives, its technological underpinnings, and the role of the government in facilitating its growth and adoption. The study is designed to provide a holistic view of ONDC, considering various aspects such as technology, policy, and market dynamics. The analysis suggests that ONDC could revolutionize India’s digital commerce ecosystem. Key findings indicate that ONDC can enhance interoperability, empower small businesses and local retailers, and diversify consumer choices. The initiative’s reliance on existing digital frameworks like the Unified Payments Interface and the Data Empowerment and Protection Architecture is crucial in streamlining transactions and bolstering data security. However, the realization of ONDC’s full potential is contingent upon its effective implementation and widespread acceptance among stakeholders. This study contributes to the existing body of knowledge by comprehensively analysing ONDC, a relatively new and underexplored area in digital commerce research. It offers original insights into the initiative’s potential to transform India’s digital commerce landscape. The article also identifies gaps in current research, such as the limited scope of existing studies, the absence of primary data, and the influence of external variables. It suggests avenues for future research, including longitudinal studies, international comparisons, and primary data collection, to understand ONDC better and its long-term impact on India’s digital commerce sector.
Anaximander on basic substances and the desiccation of the sea
Authors: Salles Ricardo 
Published: August 2024

Abstract
This paper deals with the physics of Anaximander and argues that, in his theory, the drying up of the sea cannot be accounted for in terms of the kind of conflict envisaged in his main fragment between the four basic substances: the hot, the cold, the wet and the dry (DK 12B1). In so doing, the paper takes issue with a classic interpretation of Anaximander’s cosmology advocated by Jaap Mansfeld (2011). This issue also brings us to a wider philosophical problem: are meteorological phenomena in general amenable to this conflict according to Anaximander? In the conclusion, a few conjectural remarks are made regarding what may have been the real explanandum of this theory.
Plato on the Power of Dialectic and the Necessity of Forms
Authors: Granieri Roberto 
Published: August 2024

Abstract
In the Parmenides Plato claims that by relinquishing Forms one would entirely destroy tên tou dialegesthai dunamin. I argue that this peculiar phrase does not indicate, as often suggested, the power or possibility of all discourse or thought, but the power of dialectic, i. e. the highest science; and that its preservation is, for Plato, a decisive reason for the necessity of the Forms.
A Note on the Translation of Ezra 4:12
Authors: Moore James D. , Becking Bob 
Published: August 2024

Abstract
This article provides a philological assessment of the statement in Ezra 4:12b and offers a new translation. We focus on the word יַחִיטוּ. We propose to construe the form as originally *יְחִיטוּ, G-stem prefixing conjugation of חיט, »to inspect«. In order to substantiate our proposal we refer to a series of cognates in Aramaic and other Semitic languages. Two newly edited Aramaic documents from Elephantine are mentioned, as well as texts from Bactria, passages from the Gilgamesh Epic, and the story on the Tower of Babylon.
Resuscitating »Wisdom Literature«
Authors: Frish Rachel 
Published: August 2024

Abstract
This essay offers a novel framework for the definition of biblical wisdom as a genre by suggesting self-presentation as a key to understanding the genre’s dynamics. By framing the material as sapiential, the authors/editors provide a hermeneutical tool for readers, based on a set of shared conventions. Forming the scarlet thread of the genre, this »self-identification« is »thickened« by a set of fluid features – many of which are related to the labile conventions associated with the wise. This spinal cord links later works to the tradition even when expectations change.
The Climax-Decline Pattern in the Book of Kings
Authors: Klein Neriah 
Published: August 2024

Abstract
The Book of Kings is the main source for reconstructing the chronology of the monarchic period in Israel, but it contains many contradictions and raises difficulties that make the reconstruction disputed to this day. The prevailing approach tends to attribute historical credibility to the biblical data, while few have suggested that some of the numbers have been deliberately manipulated to create symbolic or meaningful schemas. The purpose of the present study is to reinforce the artificiality of these numbers by presenting two cases of a »climax-decline pattern« at key points in the Book of Kings’ chronology, in which a king with the longest reign in the history of a kingdom is followed by a period of deterioration towards disaster over the same duration. If these regnal years have been reworked to incorporate them into the book’s literary design, then they may mislead the historian who wishes to use them to reconstruct a relative or absolute chronology.
Georg Lorenz Bauer’s
Biblische Moral des Alten Testaments
: The First »Old Testament Ethics«?
Authors: Keefer Arthur J. 
Published: August 2024

Abstract
Georg Lorenz Bauer (1755–1806) is known for coining the term »historical-critical« and writing one of the first works of Old Testament theology, but he is hardly remembered for publishing what is arguably the first independent work of Old Testament ethics. His two-volume Biblische Moral des Alten Testaments (1803) still ranks among the most extensive publications on the subject. This article situates Bauer’s work within the history of OT ethics research, arguing that it was the first of its kind, while providing an overview of its contents, methodology, and reception.
Examining the Effects of Dynamic and Isometric Resistance Training on Knee Joint Kinetics During Unplanned Sidesteps in Elite Female Athletes
Authors: Kadlec Daniel , Jordan Matthew J. , Alderson Jacqueline , Nimphius Sophia 
Published: August 2024

AbstractKadlec, D, Jordan, MJ, Alderson, J, and Nimphius, S. Examining the effects of dynamic and isometric resistance training on knee joint kinetics during unplanned sidesteps in elite female athletes.J Strength Cond ResXX(X): 000–000, 2024—The purpose of this study was to examine the effects of a 4-week block of isometric (isometricRT) and dynamic resistance training (dynamicRT) on kinetic variables associated with anterior cruciate ligament (ACL) injury risk during unplanned sidesteps in elite female athletes. Twenty-one elite female athletes competing for a women's international rugby union team were recruited with 15 (n= 15; age: 23.4 ± 4.7 years; 170.7 ± 8.4 cm; 84.4 ± 15.4 kg) completing assessment of knee flexion moment, knee valgus moment (KVM), knee internal rotation moment (KIRM), knee joint power during unplanned sidesteps, and lower limb strength before and after a 4-week intervention. Linear mixed effects models and one-dimensional statistical parametric mapping assessed the effect of the interventions. Statistical significance was set atα= 0.05. Postintervention the isometricRTgroup revealed reduced peak KVM during early stance (p= 0.04) while the dynamicRTgroup decreased peak KIRM (p< 0.01) and KIRM over 8.8–86.6% (p< 0.01) and 96.9–98.5% (p= 0.047). An exploratory combined group analysis revealed reductions in KVM over 7.9–21.8% (p= 0.002) and in KIRM over 8.3–90.5% (p< 0.01) and 96.2–98.5% (p= 0.046). Most lower limb isometric and dynamic strength measures increased after both resistance training interventions. Overall, both groups increased lower-body maximum strength while reducing kinetic knee joint variables associated with ACL injury risk during unplanned sidesteps. These results highlight the importance of increasing single-joint and multijoint strength in female athletes to mitigate the mechanical knee joint demands during sidestepping.
ST2+ T-Regulatory Cells in Renal Inflammation and Fibrosis after Ischemic Kidney Injury
Authors: Sabapathy Vikram , Price Airi , Cheru Nardos Tesfaye , Venkatadri Rajkumar , Dogan Murat , Costlow Gabrielle , Mohammad Saleh , Sharma Rahul 
Published: August 2024

Key Points

IL-33/ST2 alarmin pathway regulates inflammation, fibrosis, and resolution of ischemia-reperfusion injury of kidneys.ST2 regulates the transcriptome of T-regulatory cells related to suppressive and reparative functions.The secretome of ST2+ T-regulatory cells regulates hypoxic injury in an amphiregulin-dependent manner.

Background
Inflammation is a major cause of kidney injury. IL-1 family cytokine IL-33 is released from damaged cells and modulates the immune response through its receptor ST2 expressed on many cell types, including regulatory T cells (Tregs). Although a proinflammatory role of IL-33 has been proposed, exogenous IL-33 expanded Tregs and suppressed renal inflammation. However, the contribution of endogenous IL-33/ST2 for the role of Tregs in the resolution of kidney injury has not been investigated.

Methods
We used murine renal ischemia-reperfusion injury and kidney organoids (KDOs) to delineate the role of the ST2 and amphiregulin (AREG) specifically in Tregs using targeted deletion. Bulk and single-cell RNA sequencing were performed on flow-sorted Tregs from spleen and CD4 T cells from postischemic kidneys, respectively. The protective role of ST2-sufficient Tregs was analyzed using a novel coculture system of syngeneic KDOs and Tregs under hypoxic conditions.

Results
Bulk RNA sequencing of splenic and single-cell RNA sequencing of kidney CD4 T cells showed that ST2+ Tregs are enriched for genes related to Treg proliferation and function. Genes for reparative factors, such as Areg, were also enriched in ST2+ Tregs. Treg-specific deletion of ST2 or AREG exacerbated kidney injury and fibrosis in the unilateral ischemia-reperfusion injury model. In coculture studies, wild-type but not ST2-deficient Tregs preserved hypoxia-induced loss of kidney organoid viability, which was restored by AREG supplementation.

Conclusions
Our study identified the role of the IL-33/ST2 pathway in Tregs for resolution of kidney injury. The transcriptome of ST2+ Tregs was enriched for reparative factors including Areg. Lack of ST2 or AREG in Tregs worsened kidney injury. Tregs protected KDOs from hypoxia in a ST2- and AREG-dependent manner.
Prospective comparative study of medial parapatellar and medial subvastus approaches in total knee arthroplasty
Authors: Badawi I.A. , Ismail A.S. , Waly A.H. , Khalkaf M.A.N. 
Published: August 2024

Introduction Total knee arthroplasty (TKA) is the treatment of end-stage osteoarthritis in patients who failed to respond to conservative treatment in providing significant pain relief and improving joint function. The medial parapatellar approach (MPP) allows adequate patellar eversion and sufficient knee flexion to expose the knee joint, but the incision through the quadriceps tendon may impair the extensor mechanism of the knee post-operatively. The subvastus approach (SV) completely spares both the quadriceps tendon and muscle and provides adequate exposure of the knee joint for the replacement procedure, SV maintains integrity of the patellar blood supply and reduces post-operative pain resulting in shorter hospital stay.The aim of this prospective study was to compare the results of the medial parapatellar and subvastus approaches in primary total knee arthroplasty (TKA) regarding postoperative pain, recovery of muscle strength, range of knee motion and return to regular daily activities.Materials and Methods Sixty patients underwent TKA at El-Hadara university hospital in Alexandria. The medial parapatellar apphroach (MPP) was performed in 30 patients while the subvastus approach (SV) was used for the other 30 patients. The choice of approach was randomly assigned.Results The statistical analysis of the results at the end of a 6-month follow-up showed that there were no significant differences between the patients in group 1 (MPP) and group 2 (SV) with respect to age, gender, comorbidity, side operated or body mass index (BMI). Regarding the functional knee scores (IKDC, WOMAC), there were no differences at 4 weeks, 3 months and 6 months postoperatively between the two groups. However, we found better outcomes in the SV group regarding the VAS score during the first five postoperative days, earlier quadriceps recovery by assessment of Straight Leg Raising test (SLR), while the operative time was longer in the SV group with less blood collected postoperatively in hemovac drain in the same group.Discussion In our study during the operation via the MPP approach, the index suture positioned at the superomedial border of the patella and the opposite suture on the medial retinacular flap had enabled the surgeon to avoid patellar maltracking during closure of the wound. In the SV group, the L-shaped incision of the medial capsule was considered an efficient landmark for accurate soft tissue closure avoiding the patellar maltracking.Conclusion The subvastus approach offers the advantage of keeping the integrity of quadriceps muscle and the extensor mechanism remains intact post-surgery. It causes less pain and less blood loss postoperatively than the regular parapatellar approach. The patient could recover the knee function in a shorter time with fewer complications, which is greatly in line with the concept of ERAS (Enhanced Recovery After Surgery).
Risk factors associated with congenital clubfoot in children
Authors: Vlasov M. V. , Musikhina I. V. 
Published: August 2024

Introduction Congenital clubfoot is a frequent malformation of the lower extremities. However, the causes of this pathology in children are still unclear. The identification of the factors associated with congenital clubfoot is a relevant problem, the solution of which will allow a prenatal prevention of clubfoot in newborns thus reducing the number of patients with this pathology.Purpose The search for possible risk factors leading to a violation of foot development in the fetus and their significance in the occurrence of congenital clubfoot in children.Materials and methods The study was of retrospective nature and was carried out in pairs “Mother-Newborn”. It included examination of 149 children. The first group (n = 97) was compiled by the “Mother Newborn” pairs, in which the child had a typical form of congenital clubfoot; the second group (n = 52) were pairs in which the baby was healthy. The data obtained were processed using tables 2×2 and logistics regression.Results According to the results of the study, it was found that the greatest sensitivity and specificity of congenital clubfoot was associated with the external factor of nicotine dependence in pregnant women (SE = 0.32; SP = 0.90) and the factor of hereditarily burdened congenital foot pathology in close relatives (SE = 0.16; SP = 0.98). An acute respiratory viral infection in the anamnesis, anemia in a pregnant woman or toxicosis did not show statistically significant causal connection with the occurrence of congenital clubfoot according to the analysis using the method of logistics regression (р > 0.05) and they should not be used as prognostic ones.Discussion The data obtained by us on the paramount significance of the two “risk” factors of the congenital clubfoot development (nicotine dependence in a pregnant woman and hereditarily burdened disorder of congenital foot pathology among close relatives) were reflected only in a few scientific sources.Conclusion The risk factors of the greatest sensitivity, specificity and causal relationship with the congenital clubfoot development were associated with the adverse effects of the external factor of nicotine dependence during pregnancy and burdened heredity associated with congenital foot pathology in close relatives (р < 0.05).