bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonrandomized Comparison between Concomitant and Sequential Chemoradiotherapy with Anthracyclines in Breast Cancer
Authors: Leonardi Maria Cristina , Morra Anna , Santoro Luigi , Balduzzi Alessandra , Ivaldi Giovanni Battista , Vischioni Barbara , Ferrari Annamaria , Fodor Cristiana , Dell'Acqua Veronica , Cardinale Daniela Maria , Cipolla Carlo , Luini Alberto , Colleoni Marco , Jereczek-Fossa Barbara Alicja , Orecchia Roberto 
Published: February 2015

Purpose To evaluate the tolerance of concomitant administration of anthracycline-based chemotherapy (CHT) and 3-dimensional conformal radiotherapy (RT) after breast-conserving surgery. Methods and Materials Sixty-seven patients, treated with conservative surgery followed by 3-dimensional whole breast RT and concomitant CHT regimens including “Canadian modified” CEF (5-fluorouracil, epirubicin, cyclophosphamide) or AC (doxorubicin, cyclophosphamide) were evaluated for toxicity. They were compared in terms in compliance and acute toxicity with 67 patients irradiated sequentially after having received anthracyclines. Results Acute grade ≥2 skin toxicity was significantly higher in the concomitant group compared to the sequential group, although the incidence of Grade 3 desquamation showed no statistical difference (9% vs. 3%, p = 0.14). Haematological toxicity represented the main cause of treatment discontinuation, reporting higher rate of grade 3-4 leuco-neutropenia in the concomitant group (20.9% vs. 6%, p = 0.01). Mean RT duration was longer in the concomitant group (51 days vs. 45 days) owing to RT breaks. Late toxicity was acceptable. No symptomatic lung and heart events were reported. Radiological lung hyperdensity was detected in 27.7% of the patients in the concomitant group. Post-treatment left ventricular ejection fraction significantly decreased compared with baseline, but cardiac function remained within the normal range, without any difference between left or right-sided RT. Conclusions Although there was more acute grade ≥2 skin toxicity in the concomitant group, the rate of grade 3 dermatitis was lower than expected, suggesting some advantages of 3-D CRT over older techniques. Haematological toxicity exerted a significant impact on both RT and CHT delivery.
Gendering Pathos on the Early Modern Stage:
Authors: LAPERLE CAROL MEJIA 
Published: February 2015

Abstract
In the early modern drama of John Webster, representations of pathos invite the interrogation of rhetorical theory as a comprehensive account of the role of emotion in persuasion. A White Devil and The Duchess of Malfi reveal unexpected trajectories of passionate appeal and persuasive effect, particularly in the ways female rhetors undercut early modern rhetorical advice regarding the deployment of pathos. While contemporary rhetorical treatises, such as Thomas Wilson's The Art of Rhetoric, insist that arguments based on emotion render immediate and undeniable the connection between rhetor and audience, the female rhetors' male audiences do not acknowledge emotional persuasion as confirmation of consensus or likeness. Instead, gender difference elides the possibility for commiseration, rendering any effectiveness of female passionate appeal the product of male evaluation, and not its source. This article charts a nuanced understanding of gendered pathos in Webster's drama by employing an analysis of the treatment of pathos in rhetorical theory and the considerations of pathos in representing female sexual desire on the early modern stage.
Young Genius or Old Master? John Milton and the Two Life Cycles of Artistic Creativity
Authors: BECK JEFFREY P. 
Published: February 2015

AbstractBiographers and critics have often noted the late composition of Paradise Lost as remarkable, and indeed the narrator himself commented on the tragic wartime delay. The late publication of Paradise Lost raises important questions about the poet's creative process and more generally about creativity late in a poet's life. The article elaborates the question of whether Milton was an experimental or conceptual innovator, using economist David Galenson's dichotomy of the creative life cycle, posits a surprising answer, and explains the significance for other works of early modern art.
Software Productivity Consortium
Authors: Finneran Lisa 
Published: February 2015

Abstract
The Software Productivity Consortium (Consortium) was founded in 1985 by a group of the United States' leading companies in the aerospace, defense, electronics, and systems integration industries. The Consortium's membership has continued to expand since its founding, and now includes nearly 90 leading corporations in the telecommunications, aerospace/defense, electronics, and other industries, as well as many government agency and university affiliates. In both its original charter and its accomplishments to date, the Consortium represents a unique national resource for organizations facing the many challenges of designing and deploying large, software‐intensive systems. The Consortium was created to develop and transfer technologies needed to achieve these improvements and promote knowledge exchange and transfer across industry segments, federal and state government, and academia.
The Consortium is a nonprofit organization, located in Virginia's Center for Innovative Technology (CIT) complex adjacent to Dulles International Airport near Washington, DC.
Substorm‐induced energetic electron precipitation: Morphology and prediction
Authors: Beharrell M. J. , Honary F. , Rodger C. J. , Clilverd M. A. 
Published: February 2015

AbstractThe injection, and subsequent precipitation, of 20 to 300 keV electrons during substorms is modeled using parameters of a typical substorm found in the literature. When combined with onset timing from, for example, the SuperMAG substorm database, or the Minimal Substorm Model, it may be used to calculate substorm contributions to energetic electron precipitation in atmospheric chemistry and climate models. Here the results are compared to ground‐based data from the Imaging Riometer for Ionospheric Studies riometer in Kilpisjärvi, Finland, and the narrowband subionospheric VLF receiver at Sodankylä, Finland. Qualitatively, the model reproduces the observations well when only onset timing from the SuperMAG network of magnetometers is used as an input and is capable of reproducing all four categories of substorm associated riometer spike events. The results suggest that the different types of spike event are the same phenomena observed at different locations, with each type emerging from the model results at a different local time, relative to the center of the injection region. The model's ability to reproduce the morphology of spike events more accurately than previous models is attributed to the injection of energetic electrons being concentrated specifically in the regions undergoing dipolarization, instead of uniformly across a single‐injection region.
A set of measures for the systematic classification of the nonlinear elastic behavior of disparate rocks
Authors: Rivière Jacques , Shokouhi Parisa , Guyer Robert A. , Johnson Paul A. 
Published: February 2015

AbstractDynamic acoustoelastic testing is performed on a set of six rock samples (four sandstones, one soapstone, and one granite). From these studies at 20 strain levels 10−7<ϵ<10−5, four measures characterizing the nonlinear elastic response of each sample are found. Additionally, each sample is tested with nonlinear resonant ultrasonic spectroscopy and a fifth measure of nonlinear elastic response is found. These five measures of the nonlinear elastic response of the samples (approximately 3 × 6×20 × 5 numbers as each measurement is repeated 3 times) are subjected to careful analysis using model‐independent statistical methods, principal component analysis, and fuzzy clustering. This analysis reveals differences among the samples and differences among the nonlinear measures. Four of the nonlinear measures are sensing much the same physical mechanism in the samples. The fifth is seeing something different. This is the case for all samples. Although the same physical mechanisms (two) are operating in all samples, there are distinctive features in the way the physical mechanisms present themselves from sample to sample. This suggests classification of the samples into two groups. The numbers in this study and the classification of the measures/samples constitute an empirical characterization of rock nonlinear elastic properties that can serve as a valuable testing ground for physically based theories that relate rock nonlinear elastic properties to microscopic elastic features.
Intraseasonal sea surface salinity variability in the equatorial Indo‐Pacific Ocean induced by Madden‐Julian oscillations
Authors: Li Yuanlong , Han Weiqing , Lee Tong 
Published: February 2015

AbstractIntraseasonal sea surface salinity (SSS) variability in the equatorial Indo‐Pacific Ocean is investigated using the Aquarius/SAC‐D satellite measurements and Hybrid Coordinate Ocean Model (HYCOM). Large‐scale SSS variations at 20–90 day time scales induced by Madden‐Julian oscillations (MJOs) are prominent in the central‐to‐eastern Indian Ocean (IO) and western Pacific Ocean (PO) with a standard deviation of ∼0.15 psu. The relationship between SSS anomaly and freshwater flux is nearly in phase in the central‐to‐eastern IO and out of phase in the western PO during a MJO cycle. A series of HYCOM experiments are performed to explore the causes for SSS variability. In most areas of the equatorial Indo‐Pacific Ocean, wind stress‐forced ocean dynamical processes act as the main driver of intraseasonal SSS, while precipitation plays a secondary role. In some areas of the western PO and western IO, however, precipitation effect is the leading contributor. In comparison, evaporation effect induced by radiation and wind speed changes is generally much smaller. Besides the external forcing by MJOs, ocean internal variability can also cause considerable intraseasonal SSS changes, explaining 10–20% of the total variance in some regions. Composite analysis for MJO events reveals that the effects of wind stress, precipitation, and evaporation vary at different phases of a MJO cycle. The MJO‐induced SSS signature is the result of complicated superimposition and interaction of these effects. The effect of wind stress also varies significantly from event to event. It affects SSS variability primarily through horizontal ocean current advection and to a lesser extent through vertical entrainment.
A model study of regional air‐sea interaction in the austral summer precipitation over southern Africa
Authors: Ratnam J. V. , Morioka Yushi , Behera Swadhin K. , Yamagata Toshio 
Published: February 2015

AbstractThe importance of air‐sea interactions in the simulation of southern Africa precipitation is brought out using a fully coupled regional model and by forcing the atmospheric component of the coupled model with the coupled model‐simulated sea surface temperature (SST). The coupled model has the Advanced Research Weather Research and Forecasting model as the atmospheric component and the Regional Ocean Modeling System as the oceanic component. The spatial and temporal distribution of the coupled model‐simulated SST shows good agreement with observations. The coupled model shows a bias of about 0.25°C near the east coast of southern Africa. Comparison of the precipitation between the coupled and uncoupled model shows that the air‐sea interactions play an important role in the simulation of the precipitation during the peak precipitation season January to March, when the precipitation is mostly due to tropical processes. It is found that the two‐way specification of SST to the atmospheric model results in significant larger (smaller) precipitation depending on the spatial distribution of SST, due to the increase (decrease) of moisture from the surrounding oceans into the landmass. The results also show that the air‐sea interactions are not so important during the initial phases of the precipitation from October to December.
Enhanced nonlinearity interval mapping scheme for high‐performance simulation‐optimization of watershed‐scale BMP placement
Authors: Zou Rui , Riverson John , Liu Yong , Murphy Ryan , Sim Youn 
Published: February 2015

AbstractIntegrated continuous simulation‐optimization models can be effective predictors of a process‐based responses for cost‐benefit optimization of best management practices (BMPs) selection and placement. However, practical application of simulation‐optimization model is computationally prohibitive for large‐scale systems. This study proposes an enhanced Nonlinearity Interval Mapping Scheme (NIMS) to solve large‐scale watershed simulation‐optimization problems several orders of magnitude faster than other commonly used algorithms. An efficient interval response coefficient (IRC) derivation method was incorporated into the NIMS framework to overcome a computational bottleneck. The proposed algorithm was evaluated using a case study watershed in the Los Angeles County Flood Control District. Using a continuous simulation watershed/stream‐transport model, Loading Simulation Program in C++ (LSPC), three nested in‐stream compliance points (CP)—each with multiple Total Maximum Daily Loads (TMDL) targets—were selected to derive optimal treatment levels for each of the 28 subwatersheds, so that the TMDL targets at all the CP were met with the lowest possible BMP implementation cost. Genetic Algorithm (GA) and NIMS were both applied and compared. The results showed that the NIMS took 11 iterations (about 11 min) to complete with the resulting optimal solution having a total cost of $67.2 million, while each of the multiple GA executions took 21–38 days to reach near optimal solutions. The best solution obtained among all the GA executions compared had a minimized cost of $67.7 million—marginally higher, but approximately equal to that of the NIMS solution. The results highlight the utility for decision making in large‐scale watershed simulation‐optimization formulations.
Signatures of the ULF geomagnetic activity in the surface air temperature in Antarctica
Authors: Francia Patrizia , Regi Mauro , De Lauretis Marcello 
Published: February 2015

AbstractThe variations of the Pc5 and Pc1‐2 ULF power and surface air temperature measured at Terra Nova Bay in Antarctica have been analyzed during the late declining phase of solar cycle 23 (2007–2008), in comparison with the simultaneous variations of the solar wind speed. The analysis focused on time scales of several days, which characterize the evolution of the solar wind stream structure. The temperature variations appear clearly during the local winters, while they are strongly reduced in the sunlit summers. During the local winters, the Pc5 and Pc1‐2 power and the temperature variations are significantly correlated, with the temperature delayed by a few days with respect to the ULF power. A time‐frequency analysis revealed common signals in the temperature and ULF power at periodicities related to the Sun's rotation period (~27, 13.5, and 9 days), which, in the same time intervals, characterize the solar wind speed and geomagnetic activity.
Psychiatric disorders in children with Prader–Willi syndrome—Results of a 2‐year longitudinal study
Authors: Lo S.T. , Collin P.J.L. , Hokken‐Koelega A.C.S. 
Published: February 2015

Psychiatric disorders such as psychosis are highly prevalent in adults with Prader–Willi syndrome (PWS). However, knowledge about the presence and progression of psychiatric disorders in children with PWS is very limited. Sixty‐one children with PWS aged 7–17 years were tested using the Diagnostic Interview Schedule for Children (DISC) and Compulsive Behaviour Checklist (CBC), and 38/61 were retested after 2 years. Prevalence of psychiatric disorders and the association with age, gender, genetic subtype, and total IQ were assessed. In addition, occurrence and characteristics of compulsions were determined.Prior to the study, two boys were known with psychotic symptoms and treated with antipsychotics. At baseline, none scored positive for psychotic disorder. During the follow‐up, only one boy with known psychotic symptoms required a dose adjustment of his antipsychotic medication. After 2 years, none of the children had a psychotic disorder according to the DISC. Oppositional defiant disorder (ODD) was the most common diagnosis and present in 20% of children with PWS, and this was not associated with age (β = −0.081, P = 0.546), gender (β = 0.013, P = 0.923), genetic subtype (β = −0.073, P = 0.584), or total IQ (β = −0.150, P = 0.267). The most common compulsions were hoarding and fixed hygiene sequences.In our large group of 61 children with PWS, the majority had no psychotic disorder and no progression was found during 2‐year follow‐up. ODD was present in 20% of children. No changes in the prevalence of psychiatric disorders were found during the 2‐year follow‐up study and genetic subtype was not related to psychosis, depression, or ODD. © 2015 Wiley Periodicals, Inc.
Highly Biocompatible Nanofibrous Microspheres Self‐Assembled from Chitin in NaOH/Urea Aqueous Solution as Cell Carriers
Authors: Duan Bo , Zheng Xing , Xia Zhixiong , Fan Xiaoli , Guo Lin , Liu Jianfeng , Wang Yanfeng , Ye Qifa , Zhang Lina 
Published: February 2015

AbstractIn this work, chitin microspheres (NCM) having a nanofibrous architecture were constructed using a “bottom‐up” fabrication pathway. The chitin chains rapidly self‐assembled into nanofibers in NaOH/urea aqueous solution by a thermally induced method and subsequently formed weaved microspheres. The diameter of the chitin nanofibers and the size of the NCM were tunable by controlling the temperature and the processing parameters to be in the range from 26 to 55 nm and 3 to 130 μm, respectively. As a result of the nanofibrous surface and the inherent biocompatibility of chitin, cells could adhere to the chitin microspheres and showed a high attachment efficiency, indicating the great potential of the NCM for 3D cell microcarriers.
Cyclophanes Containing Bowl‐Shaped Aromatic Chromophores: Three Isomers of anti‐[2.2](1,4)Subphthalocyaninophane
Authors: Liu Quan , Shimizu Soji , Kobayashi Nagao 
Published: February 2015

AbstractThe connection of bowl‐shaped aromatic boron subphthalocyanines with anti‐[2.2]paracyclophane resulted in the first observation of electronic communication between convex and concave surfaces. Three isomers of anti‐[2.2](1,4)subphthalocyaninophane, described as concave–concave (CC), convex–concave (CV), and convex–convex (VV) according to the orientation of the subphthalocyanine units, were synthesized and characterized by various spectroscopic techniques, including 1H NMR, electronic absorption, fluorescence, and magnetic circular dichroism spectroscopy and X‐ray crystallography, together with molecular‐orbital calculations. On going from the CC system to CV and further to VV, the Q band broadened and finally split as a result of through‐space expansion of the conjugated systems, which were also reproduced theoretically.
Permeability of ethanol solution through poly(lactic acid) film
Authors: Shinkawa Yasuaki , Hayashi Yuki , Sato Shuichi , Nagai Kazukiyo 
Published: February 2015

ABSTRACTThe permeation properties of ethanol solution through poly(lactic acid) (PLA) films were investigated. The total flux of ethanol solution through PLA films was strongly depended on the flux of water. In addition, the diffusion coefficient of water was 1000 times higher than that of ethanol, and decreased with increasing feed concentration. After the permeation measurement, crystallization (XC‐DSC = 1–2%) was observed. However, the crystallinity was not dependent on the feed concentration. On the other hand, the mole ratio of ethanol and water molecules in the PLA film strongly depended on the feed concentration. Based on the results, we concluded that the interaction with ethanol molecules caused the decrease in diffusion coefficient of water in PLA film. Thus, the permeation mechanism of the ethanol solution to the PLA film was investigated in detail. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42031.
A novel polyacrylamide‐based superabsorbent with temperature switch for steam breakthrough blockage
Authors: Zhang Xiaoyun , Wang Xiangpeng , Li Liang , Wu Ruonan , Zhang Sisi , Wu Jihui , Wu Wei 
Published: February 2015

ABSTRACTA novel high‐temperature resistant superabsorbent polymer (SAP) with a temperature switch to control its water absorbency was prepared through solution polymerization of acrylamide (AM), usingN,N‐methylenebisacrylamide (NMBA) and tetraallylammonium chloride (TAAC) as crosslinking agents. The SAPs were structurally characterized by Fourier transform infrared (FTIR) spectroscopy and energy dispersive X‐ray spectroscopy (EDX). The factors that influence the water absorbency such as total crosslinker concentration, molar ratio of NMBA to TAAC and temperature were investigated. The SAP with optimized crosslinker concentration showed a swelling ratio less than 10 g/g at 25°C, and drastically enhanced water absorption capacity (190 g/g) at 300°C. The water absorption characteristics can be tuned by varying the temperature. Swelling experimental results combined with crosslinking density study and morphology observation by scanning electron microscopy (SEM) clearly demonstrated that the hydrolysis of amide bonds on NMBA played a critical role in creating these previously unreported SAPs, and that the use of TAAC with an appropriate amount rendered the SAPs high‐temperature resistance. This kind of SAPs has high application potentials as plugging material for steam breakthrough and channeling in heavy oil reservoirs. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2015,132, 42067.
Seasonal and Ontogenetic Variation in Subcutaneous Adipose Of the Bowhead Whale (Balaena mysticetus)
Authors: Ball Hope C. , Stavarz Madeline , Oldaker Jonathan , Usip Sharon , Londraville Richard L. , George John C. , Thewissen Johnannes G.M. , Duff Robert Joel 
Published: February 2015

ABSTRACTCetacean evolution was shaped by an extraordinary land‐to‐sea transition in which the ancestors of whales became fully aquatic. As part of this transition, these mammals evolved unusually thick blubber which acts as a metabolic reservoir as well as an insulator and provides buoyancy and streamlining. This study describes blubber stratification and correlates it to seasonal variation, feeding patterns, and ontogeny in an arctic‐adapted mysticete, the bowhead whale (Balaena mysticetus). Bowheads are unique among mammals for possessing the largest known blubber stores. We found that adipocyte numbers in bowheads, like other mammals, do not vary with season or feeding pattern but that adipocyte size and structural fiber densities do vary with blubber depth. Anat Rec, 298:1416–1423, 2015. © 2015 Wiley Periodicals, Inc.
Joints Position Estimation of a Redundant Scara Robot by Means of the Unscented Kalman Filter and Inertial Sensors
Authors: Urrea Claudio , Muñoz Rodrigo 
Published: February 2015

AbstractA method is presented for estimating the position of rotational and prismatic joints of a novel SCARA‐type fault‐tolerant redundant manipulator using inertial sensors (accelerometers and gyroscopes). The estimation is based on the integration of the different sensors by means of the modified AUKF algorithm. The results of the evaluation of this integration scheme are compared with the CMRGD and DCMR methods, which are used for the estimation of the positions of rotational joints based on inertial sensors, showing a clear advantage of the proposed integration method over existing methods for estimating the joint angles, in addition to allowing the calculation of the position of prismatic joints.