bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventionist grid development projects: a research framework based on three frames
Authors: Venters Will , Kyriakidou‐Zacharoudiou Avgousta 
Published: January 2014

PurposeThis paper seeks to consider the collaborative efforts of developing a grid computing infrastructure within problem‐focused, distributed and multi‐disciplinary projects – which the authors term interventionist grid development projects – involving commercial, academic and public collaborators. Such projects present distinctive challenges which have been neglected by existing escience research and information systems (IS) literature. The paper aims to define a research framework for understanding and evaluating the social, political and collaborative challenges of such projects.Design/methodology/approachThe paper develops a research framework which extends Orlikowski and Gash's concept of technological frames to consider two additional frames specific to such grid projects; bureaucratic frames and collaborator frames. These are used to analyse a case study of a grid development project within Healthcare which aimed to deploy a European data‐grid of medical images to facilitate collaboration and communication between clinicians across the European Union.FindingsThat grids are shaped to a significant degree by the collaborative practices involved in their construction, and that for projects involving commercial and public partners such collaboration is inhibited by the differing interpretive frames adopted by the different relevant groups.Research limitations/implicationsThe paper is limited by the nature of the grid development project studied, and the subsequent availability of research subjects.Practical implicationsThe paper provides those involved in such projects, or in policy around such grid developments, with a practical framework by which to evaluate collaborations and their impact on the emergent grid. Further, the paper presents lessons for future such Interventionist grid projects.Originality/valueThis is a new area for research but one which is becoming increasingly important as data‐intensive computing begins to emerge as foundational to many collaborative sciences and enterprises. The work builds on significant literature in escience and IS drawing into this new domain. The research framework developed here, drawn from the IS literature, begins a new stream of systems development research with a distinct focus on bureaucracy, collaboration and technology within such interventionist grid development projects.
From meticulous professionals to superheroes of the business world
Authors: Picard Claire-France , Durocher Sylvain , Gendron Yves 
Published: January 2014

Purpose– The purpose of this paper is to examine the relative cultural shift from professionalism to commercialism in the accounting profession, based on an analysis of the promotional brochures used by theOrdre des comptables agréés du Québec(Institute of Chartered Accountants of Québec), over the last 40 years, to attract new members.Design/methodology/approach– The study's specific objectives are: to examine accountancy's cultural representations depicted in promotional brochures; to evaluate the extent to which these representations are indicative of the commercialist shift as documented in the literature; and to establish whether the representations under study provide further insight into the nature of the cultural shift. Drawing on the semiotic approach developed by Roland Barthes, the authors' analysis is predicated on the idea that promotional brochures and advertisements, though often simple in appearance, constitute complex representations that convey meaningful information about influential values and cultural change.Findings– The authors found that commercial values are increasingly apparent through the celebration of multidisciplinary services and the emphasis on generous compensation and high dynamism.Originality/value– Barthes' framework was especially useful to analyze the interplay between images and text to gain insight into the historical emergence of what has become the accountant's representation of today. As such, this study points to promotional representations participating to the inculcation of a cosmopolitan culture, where the internationalization of business is supposedly natural, inevitable, and beneficial to everyone. The authors' research also highlights the increasingly significant role played by marketing experts in designing professional institutes' brochures, consistent with the broader view of marketization as a key trend within the accounting industry.
JURA: a collaborative solution to Hong Kong academic libraries storage challenge
Authors: Sidorko Peter , Lee Linda 
Published: January 2014

Purpose
– The purpose of this paper is to discuss issues and concerns raised in a collaborative and cooperative central storage facility for Hong Kong academic libraries.

Design/methodology/approach
– The approach is to propose and to implement a joint storage business plan and a possibility of acting for others to consider similar storage facilities.

Findings
– Useful experiences have been gained while planning a central storage facility.

Research limitations/implications
– The proposed JURA project is for Hong Kong academic libraries.

Practical implications
– The sharing of JURA proposal to create a central storage will inform the libraries around the region of the benefits of having a useful facility in the long term.

Originality/value
– The paper will inform others wishing to set up collaborative storages on governance, storage systems, business plan, problems and issues in what is still a relatively unexplored approach to storage problems.
Defoliation effects on seed dispersal and seedling recruitment in a tropical rain forest understorey palm
Authors: van Lent Jeffrey , Hernández‐Barrios Juan C. , Anten Niels P. R. , Martínez‐Ramos Miguel 
Published: January 2014

Summary

Assessing the demographic effects of leaf area losses in perennial plants is important to determine population resilience to natural and anthropogenic disturbances. Yet, while impacts of defoliation on vital rates of adult plants have been well documented, consequences for seed dispersal and seedling recruitment have been barely explored.

Here, we assessed the effects of defoliation on fruit production, fruit/seed size, seed dispersal and seedling recruitment in populations of Chamaedorea ernesti‐augustii, a tropical rain forest, understorey palm from Mesoamerica, whose leaves are exploited as a highly valuable non‐timber forest product (NTFP).

Fruit size and seed production were quantified in mature palms that were subjected to 0% (control), 25%, 50%, 75% and 100% experimental removal of standing leaves, applied every 6 months over 2 years. Seed dispersal by birds and gravity, and seed predation by small vertebrates on the ground were also quantified. Rates of seedling recruitment were recorded in non‐defoliated and ‘sterile’ populations (75% sustained defoliation and periodical removal of all produced fruits). Finally, a stochastic model was used to quantify the overall effect of defoliation on seedlings recruited from locally (i.e. dispersed by gravity) and immigrant produced seeds (i.e. dispersed by birds).

Increasing defoliation strongly reduced seed production. The probability of bird dispersal was positively correlated with fruit/seed size. Isolated (i.e. bird‐dispersed) seeds endured lower predation rates than grouped (i.e. gravity‐dispersed) ones. Modelling showed that seedling recruitment rate is severely reduced in highly defoliated populations due to a strong decline in the number of seedlings coming from local seed sources. Surrounding non‐defoliated populations could partly compensate for this effect via seedlings coming from immigrant seeds.

Synthesis. Chronic and intense defoliation negatively affects seed production and dispersal, which reduces the probability of seedling recruitment. Such effects may have a profound impact on the dynamics and genetic variability of populations, which should be taken into account when considering the effects of natural defoliation and sustainability of leaf‐harvesting regimes.
The distribution of intraocular pressure and associated systemic factors in a Korean population: The Korea National Health and Nutrition Examination Survey
Authors: Kim Mi Jeung , Park Ki Ho , Kim Chan Yun , Jeoung Jin Wook , Kim Seok Hwan 
Published: January 2014

AbstractPurposeTo investigate the distribution of intraocular pressure (IOP) and its associated factors in a large Korean population based on the data from the nationwide cross‐sectional survey.MethodsWe obtained 2009–2010 data from the Korea National Health and Nutrition Examination Survey (KNHANES) (n = 17 901). After excluding individuals under 19 years of age, a total of 13 431 subjects were enrolled. All participants completed a comprehensive questionnaire and underwent an ocular examination including measurement of IOP by Goldmann applanation tonometry, as well as a systemic evaluation including blood pressure measurements, anthropometry and blood tests.ResultsThe mean IOP in the right eye was 13.99 ± 2.75 mmHg, and in the left eye, 13.99 ± 2.75 mmHg, representing no significant bilateral difference. There was, however, a significant difference between males (14.19 ± 2.78 mmHg) and females (13.79 ± 2.70 mmHg) (p < 0.001). Multiple regression analysis revealed that higher IOP was significantly correlated with male sex, higher myopic refractive error, higher body mass index, higher systolic blood pressure, higher fasting plasma glucose and higher total cholesterol (all p < 0.05). On the other hand, age, histories of smoking or migraine or cold hands/feet were not significantly correlated with IOP (all p > 0.05).ConclusionsIn the general Korean population, IOP increases with male sex and increasing myopia. Further, IOP is significantly correlated with systemic factors relating to cardiovascular disease and metabolic syndrome.
EQ‐5D‐Y as a health‐related quality of life measure in children and adolescents with functional disability in Sweden: testing feasibility and validity
Authors: Burström K , Bartonek Å , Broström EW , Sun S , Egmar A‐C 
Published: January 2014

AbstractAimThe EQ‐5D‐Y is a newly developed generic instrument measuring health‐related quality of life in children and adolescents.The aim of the study was to test the feasibility and validity of the EQ‐5D‐Y in a Swedish patient sample of children and adolescents with functional motor, orthopaedic and medical disabilities and to compare the results with a general population sample.MethodsTwo samples of children and adolescents answered the EQ‐5D‐Y and a core set of internationally standardised instruments, variables and socio‐demographic questions. Patients with functional disability (n = 71, aged seven to 17 years) and individuals from the general population (n = 407, aged eight to 16 years) were included in this study.ResultsThere was a low number of missing answers. Significantly more problems were reported in all dimensions in the patient sample, and the mean visual analogue scale (VAS) score was significantly lower. Any problems were reported by 83% of the patients and by 37% of the general population. In the patient sample, 21% reported problems at the most severe level, compared with 1.5% in the general population sample. By subgroup analyses by diagnoses, the frequency of reported problems in the different dimensions varied.ConclusionEven though feasibility and discriminative validity of the EQ‐5D‐Y were supported in our study, further studies are needed including more patients and patient groups.
Natural orifice specimen extraction using prolapsing technique in single‐incision laparoscopic colorectal resections for colorectal cancers
Authors: Katsuno Goutaro , Fukunaga Masaki , Nagakari Kunihiko , Yoshikawa Seiichiro , Ouchi Masakazu , Hirasaki Yoshinori , Azuma Daisuke 
Published: January 2014

AbstractIntroductionIt is often technically difficult to cut the lower rectum with an endoscopic linear stapler in single‐incision laparoscopic colorectal resections (SILC) because some surgical devices are inserted through the same access platform. If the rectum is cut incorrectly, it may cause anastomotic leakage. We recently applied natural orifice specimen extraction (NOSE) using the prolapsing technique to overcome this technical difficulty in SILC procedures in selected patients.Materials and Surgical TechniqueThe access platform is placed in the small umbilical incision area. SILC is performed using a surgical technique similar to the conventional laparoscopic medial‐to‐lateral approach. The proximal part of the tumor site is transected with laparoscopic staplers. Then, the tumor lesion and bowel are pulled out of the body through the anus by means of inversion. Next, the distal side of the bowel is cut with a stapler and the rectal stump is reinforced with sutures under direct vision. The distal side of the bowel is then pushed back into the body. NOSE with prolapsing technique is then complete. After that, the anvil is attached to the proximal part of the bowel at the umbilical incision site, and intracorporeal anastomosis is performed.DiscussionNOSE with prolapsing technique was applied in 14 SILC procedures for colorectal cancer patients. All procedures were successful, and there were no anastomotic leakages in the series. This technique enabled us to perform pure SILC safely without affecting cosmesis, even in cases where we needed to cut the lower rectum.
Successful thoracoscopic removal of a giant teratoma following extraction of cystic conponents: A case report
Authors: Miyauchi Yoshihiro , Matsubara Hirochika , Uchida Tsuyoshi , Matsuoka Hiroyasu , Ichihara Tomofumi , Matsumoto Masahiko 
Published: January 2014

AbstractVideo‐assisted thoracoscopic surgery is a type of minimal‐access surgery. The nature of the surgery means that there are limitations on the size of a tumor that can be removed through an access incision. Herein, we report our experience removing a giant teratoma (16 × 14 × 13 cm in size) from the anterior mediastinum of a young girl. We employed video‐assisted thoracoscopic surgery to remove the teratoma through a mini‐thoracotomy following the extraction of the cystic components.
Pancreatoduodenal artery aneurysm resulting from median arcuate ligament compression successfully treated with laparoscopic ligament section
Authors: Hiramatsu Yoshihiro , Sakaguchi Takanori , Kawabata Toshiki , Shibasaki Yasushi , Kikuchi Hirotoshi , Takehara Yasuo , Uyama Ichiro , Konno Hiroyuki 
Published: January 2014

AbstractTrue aneurysms of the pancreatoduodenal arteries are frequently associated with stenosis or occlusion of the celiac trunk caused by median arcuate ligament compression. Celiac stenosis cannot be cured, even by transarterial embolization, which has recently become a good alternative to open surgical repair. To prevent recurrence, management of median arcuate ligament compression to correct hemodynamics in vascular networks should also be performed. Herein we report a case of pancreatoduodenal arterial aneurysm with median arcuate ligament compression that was successfully treated with minimally invasive laparoscopic median arcuate ligament section. The patient was discharged 4 days after surgery with no complications. Enhanced CT 1 month after surgery revealed no residual celiac trunk stenosis or aneurysm. Normalization of blood flow by laparoscopic median arcuate ligament section is a good option for some patients with a pancreatoduodenal arterial aneurysm.
Ultrahigh dimensional time course feature selection
Authors: Xu Peirong , Zhu Lixing , Li Yi 
Published: January 2014

SummaryStatistical challenges arise from modern biomedical studies that produce time course genomic data with ultrahigh dimensions. In a renal cancer study that motivated this paper, the pharmacokinetic measures of a tumor suppressor (CCI‐779) and expression levels of 12,625 genes were measured for each of 33 patients at 8 and 16 weeks after the start of treatments, with the goal of identifying predictive gene transcripts and the interactions with time in peripheral blood mononuclear cells for pharmacokinetics over the time course. The resulting data set defies analysis even with regularized regression. Although some remedies have been proposed for both linear and generalized linear models, there are virtually no solutions in the time course setting. As such, a novel GEE‐based screening procedure is proposed, which only pertains to the specifications of the first two marginal moments and a working correlation structure. Different from existing methods that either fit separate marginal models or compute pairwise correlation measures, the new procedure merely involves making a single evaluation of estimating functions and thus is extremely computationally efficient. The new method is robust against the mis‐specification of correlation structures and enjoys theoretical readiness, which is further verified via Monte Carlo simulations. The procedure is applied to analyze the aforementioned renal cancer study and identify gene transcripts and possible time‐interactions that are relevant to CCI‐779 metabolism in peripheral blood.
Semiparametric analysis of incomplete current status outcome data under transformation models
Authors: Wen Chi‐Chung , Chen Yi‐Hau 
Published: January 2014

SummaryThis work, motivated by an osteoporosis survey study, considers regression analysis with incompletely observed current status data. Here the current status data, including an examination time and an indicator for whether or not the event of interest has occurred by the examination time, is not observed for all subjects. Instead, a surrogate outcome subject to misclassification of the current status is available for all subjects. We focus on semiparametric regression under transformation models, including the proportional hazards and proportional odds models as special cases. Under the missing at random mechanism where the missingness of the current status outcome can depend only on the observed surrogate outcome and covariates, we propose an approach of validation likelihood based on the likelihood from the validation subsample where the data are fully observed, with adjustments of the probability of observing the current status outcome, as well as the distribution of the surrogate outcome in the validation subsample. We propose an efficient computation algorithm for implementation, and derive consistency and asymptotic normality for inference with the proposed estimator. The application to the osteoporosis survey data and simulations reveal that the validation likelihood performs well; it removes the bias from the “complete case” analysis discarding subjects with missing data, and achieves higher efficiency than the inverse probability weighting analysis.
MET dysregulation is a hallmark of aggressive disease in multiple myeloma patients
Authors: Rocci Alberto , Gambella Manuela , Aschero Simona , Baldi Ileana , Trusolino Livio , Cavallo Federica , Gay Francesca , Larocca Alessandra , Magarotto Valeria , Omedè Paola , Isaia Gianluca , Bertotti Andrea , Liberati Anna M. , Catalano Lucio , De Rosa Luca , Musto Pellegrino , Vallone Roberto , Falcone Antonietta , Drandi Daniela , Ladetto Marco , Comoglio Paolo M. , Boccadoro Mario , Palumbo Antonio 
Published: January 2014

SummaryAbnormal activation of MET/HGF (Hepatocyte Growth Factor) pathway has been described in several tumours and increased HGF plasmatic levels have been detected in patients with aggressive multiple myeloma (MM). MET and HGF mRNA expression was investigated in 105 samples of purified plasma cells derived from newly diagnosed MM patients treated with bortezomib‐based induction therapy. Gene expression was compared with response to therapy and clinical outcome. MET gene copy number was also evaluated. MET mRNA expression was higher in CD138+ than in CD138− cells (median 76·90 vs. 11·24; P = 0·0009). Low MET mRNA expression characterized patients with better response (complete response or very good partial response) compared to other patients (median 56·10 vs. 134·83; P = 0·0006). After a median follow‐up of 50 months, patients with high MET mRNA expression displayed a worse progression‐free survival (PFS; P = 0·0029) and overall survival (OS; P = 0·0023) compared to those with low MET mRNA levels. Patients with both high MET mRNA expression and high β2‐microglobulin level (>5·5 mg/l) had further worse median PFS (P < 0·0001) and OS (P < 0·0001). Patients carrying 4 MET gene copies (8 out of 82, 9·8%) also had a short PFS. High MET mRNA expression identifies patients with dismal PFS and OS and the combination with high β2‐microglobulin further characterizes patients with worse outcome.
THE IMPACT OF DOMESTIC AND FOREIGN COMPETITION ON SECTORAL GROWTH: A CROSS‐COUNTRY ANALYSIS
Authors: Joanna Wolszczak‐Derlacz 
Published: January 2014

ABSTRACTThis paper examines the impact of competition on the total factor productivity (TFP) of 21 manufacturing sectors in eighteen OECD countries over the period of time 1990–2006. We assume that the source of TFP growth can be either domestic or foreign innovation or technology transfer from the technological frontier. Trade openness, R&D, and human capital can have two effects: a direct effect on TFP (e.g., through innovation) and an indirect effect depending on the productivity gap between a given country and the technological frontier. We find that tougher domestic competition is always associated with higher sectoral productivity. Both import and export penetrations are positively associated with an increase of TFP. However, the channels through which higher TFP is materialized are different: export penetration works through level effect, while import penetration acts mainly when conditional on the level of technological development. The economical magnitude of the effect is not trivial.