bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human papillomavirus type 52 polymorphism and high‐grade lesions of the uterine cervix
Authors: Formentin Aurélie , Archambault Jacques , Koushik Anita , Richardson Harriet , Brassard Paul , Franco Eduardo L. , Coutlée Francois 
Published: September 2012

AbstractThe association between polymorphism of human papillomavirus type 52 (HPV52) and high‐grade cervical intraepithelial neoplasia (CIN2,3) was investigated in Canadian women. HPV‐52‐positive endocervical specimens collected from 216 women selected from a total of 3,614 participants recruited in two case‐control and two cohort studies conducted in Canada, were further analyzed by PCR‐sequencing of the LCR and E6 gene. Overall, the HPV52 LCR prototype was detected more frequently in Caucasian women (69 of 132, 52.3%, 95% confidence interval (CI): 43.8%–60.6%) than in non‐Caucasian women (15 of 48, 31.3%, 95% CI 19.9%–45.4%). In two cohort studies, HPV52 prototype was detected in seven of 15 (46.7%, 95% CI 24.8–69.9) HPV52 persistent infections and 14 of 35 (40.0%, 95% CI 25.5–56.5) transient infections (p = 0.76). In two case‐control studies, 30 participants did not have CIN, 18 had low‐grade CIN (CIN1), 64 had CIN2,3, seven had cervical cancer and the diagnosis was undefined for 27 women. Variant MTL‐52‐LCR‐02 was detected more frequently in women with cancer (28.6%, 95% CI 7.6%–64.8%) than in women without cancer or CIN2,3 (0%, 95% CI 0.0%–9.2%; p = 0.015). CIN2,3 risk was significantly associated with a deletion at nucleotide position 7695 in the LCR (OR 4.9, 95% CI 1.2–20.8), the T7744C variation in the LCR (OR 5.7, 95% CI 1.1–32.0), and the K93R variation in E6 (OR 6.9, 95% CI 1.3–36.8), after adjusting for age, detection of HPV16 or 18 and study site. These findings indicate that HPV52 polymorphism influences risk of CIN‐2,3 and possibly invasive cancer.
Menstrual and reproductive factors in women, genetic variation in CYP17A1, and pancreatic cancer risk in the European prospective investigation into cancer and nutrition (EPIC) cohort
Authors: Duell Eric J. , Travier Noémie , Lujan‐Barroso Leila , Dossus Laure , Boutron‐Ruault Marie‐Christine , Clavel‐Chapelon Françoise , Tumino Rosario , Masala Giovanna , Krogh Vittorio , Panico Salvatore , Ricceri Fulvio , Redondo Maria Luisa , Dorronsoro Miren , Molina‐Montes Esther , Huerta José M. , Barricarte Aurelio , Khaw Kay‐Tee , Wareham Nick J. , Allen Naomi E. , Travis Ruth , Siersema Peter D. , Peeters Petra H.M. , Trichopoulou Antonia , Fragogeorgi Eirini , Oikonomou Eleni , Boeing Heiner , Schuetze Madlen , Canzian Federico , Lukanova Annekatrin , Tjønneland Anne , Roswall Nina , Overvad Kim , Weiderpass Elisabete , Gram Inger Torhild , Lund Eiliv , Lindkvist Björn , Johansen Dorthe , Ye Weimin , Sund Malin , Fedirko Veronika , Jenab Mazda , Michaud Dominique S. , Riboli Elio , Bueno‐de‐Mesquita H. Bas 
Published: September 2012

AbstractMenstrual and reproductive factors and exogenous hormone use have been investigated as pancreatic cancer risk factors in case‐control and cohort studies, but results have been inconsistent. We conducted a prospective examination of menstrual and reproductive factors, exogenous hormone use and pancreatic cancer risk (based on 304 cases) in 328,610 women from the EPIC cohort. Then, in a case‐control study nested within the EPIC cohort, we examined 12 single nucleotide polymorphisms (SNPs) in CYP17A1 (an essential gene in sex steroid metabolism) for association with pancreatic cancer in women and men (324 cases and 353 controls). Of all factors analyzed, only younger age at menarche (<12 vs. 13 years) was moderately associated with an increased risk of pancreatic cancer in the full cohort; however, this result was marginally significant (HR = 1.44; 95% CI = 0.99–2.10). CYP17A1 rs619824 was associated with HRT use (p value = 0.037) in control women; however, none of the SNPs alone, in combination, or as haplotypes were associated with pancreatic cancer risk. In conclusion, with the possible exception of an early age of menarche, none of the menstrual and reproductive factors, and none of the 12 common genetic variants we evaluated at the CYP17A1 locus makes a substantial contribution to pancreatic cancer susceptibility in the EPIC cohort.
The association of red blood cell n-3 and n-6 fatty acids with bone mineral density and hip fracture risk in the women's health initiative
Authors: Orchard Tonya S , Ing Steven W , Lu Bo , Belury Martha A , Johnson Karen , Wactawski-Wende Jean , Jackson Rebecca D 
Published: September 2012

Abstract
Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFA) in red blood cells (RBCs) are an objective indicator of PUFA status and may be related to hip fracture risk. The primary objective of this study was to examine RBC PUFAs as predictors of hip fracture risk in postmenopausal women. A nested case-control study (n = 400 pairs) was completed within the Women's Health Initiative (WHI) using 201 incident hip fracture cases from the Bone Mineral Density (BMD) cohort, along with 199 additional incident hip fracture cases randomly selected from the WHI Observational Study. Cases were 1:1 matched on age, race, and hormone use with non–hip fracture controls. Stored baseline RBCs were analyzed for fatty acids using gas chromatography. After removing degraded samples, 324 matched pairs were included in statistical analyses. Stratified Cox proportional hazard models were constructed according to case-control pair status; risk of fracture was estimated for tertiles of RBC PUFA. In adjusted hazard models, lower hip fracture risk was associated with higher RBC α-linolenic acid (tertile 3 [T3] hazard ratio [HR]: 0.44; 95% confidence interval [CI], 0.23–0.85; p for linear trend 0.0154), eicosapentaenoic acid (T3 HR: 0.46; 95% CI, 0.24–0.87; p for linear trend 0.0181), and total n-3 PUFAs (T3 HR: 0.55; 95% CI, 0.30–1.01; p for linear trend 0.0492). Conversely, hip fracture nearly doubled with the highest RBC n-6/n-3 ratio (T3 HR: 1.96; 95% CI, 1.03–3.70; p for linear trend 0.0399). RBC PUFAs were not associated with BMD. RBC PUFAs were indicative of dietary intake of marine n-3 PUFAs (Spearman's rho = 0.45, p &lt; 0.0001), total n-6 PUFAs (rho = 0.17, p &lt; 0.0001) and linoleic acid (rho = 0.09, p &lt; 0.05). These results suggest that higher RBC α-linolenic acid, as well as eicosapentaenoic acid and total n-3 PUFAs, may predict lower hip fracture risk. Contrastingly, a higher RBC n-6/n-3 ratio may predict higher hip fracture risk in postmenopausal women. © 2013 American Society for Bone and Mineral Research.
Effects of zoledronate versus placebo on spine bone mineral density and microarchitecture assessed by the trabecular bone score in postmenopausal women with osteoporosis: A three-year study
Authors: Popp Albrecht W , Guler Sabina , Lamy Olivier , Senn Christoph , Buffat Helene , Perrelet Romain , Hans Didier , Lippuner Kurt 
Published: September 2012

Abstract
The trabecular bone score (TBS) is an index of bone microarchitectural texture calculated from anteroposterior dual-energy X-ray absorptiometry (DXA) scans of the lumbar spine (LS) that predicts fracture risk, independent of bone mineral density (BMD). The aim of this study was to compare the effects of yearly intravenous zoledronate (ZOL) versus placebo (PLB) on LS BMD and TBS in postmenopausal women with osteoporosis. Changes in TBS were assessed in the subset of 107 patients recruited at the Department of Osteoporosis of the University Hospital of Berne, Switzerland, who were included in the HORIZON trial. All subjects received adequate calcium and vitamin D3. In these patients randomly assigned to either ZOL (n = 54) or PLB (n = 53) for 3 years, BMD was measured by DXA and TBS assessed by TBS iNsight (v1.9) at baseline and 6, 12, 24, and 36 months after treatment initiation. Baseline characteristics (mean ± SD) were similar between groups in terms of age, 76.8 ± 5.0 years; body mass index (BMI), 24.5 ± 3.6 kg/m2; TBS, 1.178 ± 0.1 but for LS T-score (ZOL–2.9 ± 1.5 versus PLB–2.1 ± 1.5). Changes in LS BMD were significantly greater with ZOL than with PLB at all time points (p &lt; 0.0001 for all), reaching +9.58% versus +1.38% at month 36. Change in TBS was significantly greater with ZOL than with PLB as of month 24, reaching +1.41 versus–0.49% at month 36; p = 0.031, respectively. LS BMD and TBS were weakly correlated (r = 0.20) and there were no correlations between changes in BMD and TBS from baseline at any visit. In postmenopausal women with osteoporosis, once-yearly intravenous ZOL therapy significantly increased LS BMD relative to PLB over 3 years and TBS as of 2 years. © 2013 American Society for Bone and Mineral Research.
Theoretical description of dihydrogen/hydride and trihydride molybdocene complexes: An insight from static and molecular dynamics simulations
Authors: Piękoś Łukasz , Mitoraj Mariusz Paweł 
Published: September 2012

AbstractIn this studyab initioCar–Parrinello molecular dynamics simulations, extended transition state (ETS)‐natural orbitals for chemical valence (NOCV) and QTAIM bonding analyses, were performed to characterize the ansa‐bridged molybdocene complexes [(C5H4)2XMe2MoH3]+for X = C, Si, Ge, Sn, Pb, and nonbridged Cp2MoHsystem. The results have shown that the [(C5H4)2CMe2MoH(H2)]+complex exhibits nonclassical dihydrogen/hydride (H2/H) conformation (97.6% of time of simulation), contrary to trihydride (H3) structure noted for nonbridged Cp2MoH(86.9%) and ansa‐bridged [(C5H4)2SnMe2MoH3]+(84.8%), [(C5H4)2PbMe2MoH3]+(84.9%) systems. Further, [(C5H4)2SiMe2MoH3]+and [(C5H4)2GeMe2MoH3]+complexes, appeared to exist in both conformations (H2/H—55.4%, H3—44.6% for Si‐based system and H2/H—36.2%, H3—63.8 % for germanium congener). It has been proven that the “steric availability” of the metal center, measured by the changes in the CpMoCp angle (α), determines the existence of a given conformation—namely, the smaller value of the angle (molybdenum is sterically more accessible) the larger preference for the formation of dihydrogen/hydride structure. ETS‐NOCV method allowed to conclude that increase in the CpMoCp angle (from α ca. 120° to α ca. 150°) leads to the enhancement of donation from H2and back‐donation from Mo to the σ*(HH), what consequently leads to breaking of the HH bond and formation of the trihydride structure. Systematical increase in the charge depletion from the σ‐bonding orbital of H2can be related to the reduction of the energy gap between the major orbitals involved in this contribution, namely highest occupied molecular orbital (HOMO) of H2with lowest unoccupied molecular orbital (LUMO) of [MoHL]+; ΔE= 0.0868 a.u. [for L =(C5H4)2C], ΔE= 0.0827a.u. [for L = (C5H4)2Si] ΔE= 0.0638 a.u. [for L = Cp2]. Further, the relatively low energetic barrier to hydrogen exchange (ΔE#= 3.3 kcal/mol) for carbon‐bridged complex, [(C5H4)2CMe2MoHc(HaHb)]+→ [(C5H4)2CMe2MoHa(HbHc)]+, is related to strengthening of the Mo–H bonds when going from the substrate to the transition state (TS). Notably higher barrier to hydrogen rotation (ΔE#= 10.1 kcal/mol) in [(C5H4)2CMe2MoH(H2)]+is due to lowering in the electrostatic stabilization as well as weakening of the donation (H2→ Mo charge transfer) and practically lack‐of back‐donation (Mo → H2) in the rotated TS. © 2012 Wiley Periodicals, Inc.
Monitoring the initial delivery of an oncolytic measles virus encoding the human sodium iodide symporter to solid tumors using contrast‐enhanced computed tomography
Authors: Penheiter Alan R. , Dingli David , Bender Claire E. , Russell Stephen J. , Carlson Stephanie K. 
Published: September 2012

AbstractBackgroundWe aimed to determine the feasibility of monitoring viral delivery and initial distribution to solid tumors using iodinated contrast agent and micro‐computed tomography (CT).MethodsHuman BxPC‐3 pancreatic tumor xenografts were established in nude mice. An oncolytic measles virus with an additional transcriptional unit encoding the sodium iodide symporter (NIS), as a reporter for viral infection, was mixed with a 1:10 dilution of Omnipaque 300 (GE Healthcare, Milwaukee, WI, USA) contrast agent and injected directly into tumors. Mice were imaged with micro‐CT immediately before and after injection to determine the location of contrast agent/virus mixture. Mice were imaged again on day 3 after injection with micro‐single‐photon emission CT/CT to determine the location of NIS‐mediated 99mTcO4 transport.ResultsA 1:10 dilution of Omnipaque had no effect on viral infectivity or cell viability in vitro and was more than adequate for CT imaging of the intratumoral injectate distribution. The volume of tumor coverage with initial CT contrast agent and the 3‐day postinfection measurement of virally infected tumor volume were significantly correlated. Additionally, regions of the tumor that did not receive contrast agent from the initial injection were largely devoid of viral infection at early time points.ConclusionsContrast‐enhanced viral delivery enables a rapid and accurate prediction of the initial viral distribution within a solid tumor. This technique should enable real‐time monitoring of viral propagation from initially infected tumor regions to adjacent tumor regions. Copyright © 2012 John Wiley & Sons, Ltd.
Occupational therapy in rural India
Authors: Kenkre Indira R. 
Published: September 2012

AbstractIndia is called the land of villages. In 1951, 82.7% of the Indian population lived in rural areas. Sanskritisation and urbanisation have changed the pattern. It is expected that by the year 2020 this percentage would come down to 55%. These villagers are relocating in urban slums. Thus from the rehabilitation point of view both problems pose challenges. An Indian village community is a political, economic and cultural unit. At the urban slum area at Malwani and in small villages near Juchandra, community rehabilitation programmes were found to be most pragmatic. Community education and preventive occupational therapy are found to be essential steps in rural rehabilitation. Therapists have to work on ‘disability, attitude and beliefs’ and change the behaviour to deal with the grass root (basic) causes. It is felt that for longer sustainment, community‐based rehabilitation should originate within the community. Heath professionals must recognise the capabilities of individuals within the support structure of the family and community, while helping individuals to improve the quality of their lives.
Oral sensorimotor therapy: Assessment, efficacy and future directions
Authors: Gisel Erika G. 
Published: September 2012

AbstractThis review addresses the current state of knowledge in oral sensorimotor therapy for children with neurological impairments and ingestive problems. Comprehensive assessment of the child with dysphagia looks at the interaction of oral performance and growth. These domains include eating efficiency, oral‐motor skills, oral sensory evaluation, classification of the severity of an eating problem, interaction of respiration and ingestion, aspiration, positioning for feeding, social skills assessment, careload and assessment technologies. Oral sensorimotor therapy improves eating but not drinking skills in children 3–12 years of age. Weight gain is sufficient so that children maintain their growth channel but they do not show catchup growth. Many factors thought to contribute to better ingestive performance need further study, such as jaw and lip control in association with drinking. The earliest possible identification of infants at risk for eating impairments needs to be rigorously pursued. Such an approach offers hope that the later growth deterioration now seen in children with eating impairments may be prevented. Finally, the effect of positioning and the use of eating equipment to promote self‐feeding need further study.
An interrater reliability study of the revised elderly persons' disability scale
Authors: Drever Fiona , Nicol Maggie 
Published: September 2012

AbstractThe aim of this study was to investigate the interrater reliability of the Revised Elderly Persons' Disability Scale (REPDS). In a correlational design four raters assessed 15 subjects all over the age of 65, and diagnosed as having dementia of varying stages of severity. All subjects attended day hospital facilities and were assessed by the raters. The raters comprised two staff nurses, one occupational therapist and one occupational therapy helper. Kendall's coefficient of concordance (W) was used to determine the overall interrater reliability of the REPDS as well as the seven subsections which make up this assessment tool. It was found that all of the subsections and the overall scale obtained significant values of W at the p < 0.05 level. The Spearman rank order correlation coefficient (rs) was used to compare the raters' scores individually, which suggested that the qualified members of the staff achieved slightly higher levels of interrater reliability in comparison to an unqualified staff member.
Clinical observations and developmental coordination disorder: Is there a relationship?
Authors: McConnell David B. 
Published: September 2012

AbstractThis exploratory investigation examined the validity of using Wilson's format of clinical observations to assess children with developmental coordination disorder (DCD). Wilson's Clinical Observations format closely follows the original format by Johnson and is based on the work of A. J. Ayres. Forty‐five children 6–9 years of age, including 15 children with DCD, 15 children below average and 15 children average or better in their motor skill performance were assessed using clinical observations. Differences among these three groups of children were significant or approached significance on 19 out of 36 observations. The implications of the findings for using clinical observations to assess children with DCD are discussed.
The impact on occupational therapists of the reorganisation of psychiatric care in Sweden
Authors: Gahnström‐Strandqvist Kitty , Andersson Lars , Josephsson Staffan 
Published: September 2012

AbstractThe present study focuses on the on‐going reorganisation of psychiatric care in a major county council in Sweden. The aim of this study is to describe the impact of these changes from the perspective of one group of occupational therapists. Data were collected by a mailed questionnaire. Results showed an acceptance of the current policies towards restructuring psychiatric care, especially on the focus on alternative living and work/occupational facilities. Strong criticism was raised concerning the lack of trans‐institutional facilities. Loneliness and isohtion were seen as a main problem of the patients. Strong doubts were raised concerning independent living as the best alternative for most of the patients. The new professional role in community psychiatric care has brought the occupational therapist closer to die individual patient. Feelings of shortcomings and frustration in this group of occupational therapists regarding the reorganisation of psychiatric care were linked to the insufficiency of community support facilities designed to meet these new challenges.
Historical research: The first decade of occupational therapy in Israel: 1946–1956
Authors: Sachs Dalia , Sussman Nira 
Published: September 2012

AbstractThe present study examined the first decade of the development of occupational therapy in Israel: 1946–1956. The structural‐functional approach to the study of professions, which provided the theoretical framework for this study, identifies three formal organisations in the professions: the practice, the educational system, and the association. The purpose of this article was to follow the development of occupational therapy and to examine the interrelations of the profession's three formal organisations in the reviewed period. The methodology of the study was based on qualitative historical methods. Data collection included oral histories, and published and unpublished written material. Data organisation and analysis were within the framework of the structural‐functional approach. Data analysis indicated that ‘expansion’ was a major theme affecting the development of occupational therapy, the reason for which lies within the historical background of the period under investigation. In addition, data indicated that the practice was the strongest and most active organisation in occupational therapy and that expansion in practice was beyond the capacity of both the educational system and the professional association. The interrelations of the three formal organisations, and the rapid expansion of occupational therapy practice, had a lasting effect on the development of occupational therapy in Israel.
Contribution of myeloid cell subsets to liver fibrosis in parasite infection
Authors: Beschin Alain , De Baetselier Patrick , Van Ginderachter Jo A 
Published: September 2012

AbstractAccumulation of extracellular matrix components secreted by fibroblasts is a normal feature of wound healing during acute inflammation. However, during most chronic/persistent inflammatory diseases, this tissue repair mechanism is incorrectly regulated and results in irreversible fibrosis in various organs. Fibrosis that severely affects tissue architecture and can cause organ failure is a major cause of death in developed countries. Organ‐recruited lymphoid (mainly T cells) and myeloid cells (eosinophils, basophils, macrophages and DCs) have long been recognized in their participation to the development of fibrosis. In particular, a central role for recruited monocyte‐derived macrophages in this excessive connective tissue deposit is more and more appreciated. Moreover, the polarization of monocyte‐derived macrophages in classically activated (IFNγ‐dependent) M1 cells or alternatively activated (IL‐4/IL‐13) M2 cells, that mirrors the Th1/Th2 polarization of T cells, is also documented to contribute differentially to the fibrotic process. Here, we review the current understanding of how myeloid cell subpopulations affect the development of fibrosis in parasite infections. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Prenatal detection of del(10)(q11.2) mosaicism in chorionic villus specimens likely caused by a common chromosomal fragile site FRA10G is associated with a normal phenotype
Authors: Liao Jun , Sathanoori Malini , Yatsenko Svetlana A. , Hu Jie , Kochmar Sally J. , Hoffner Lori , Hogge W. Allen , Surti Urvashi 
Published: September 2012

ABSTRACTObjectiveTo summarize the pregnancy outcomes of cases with mosaicism for chromosome 10q11.2 deletion detected by chorionic villus sampling (CVS) and determine whether extensive cytogenetic work‐up and follow‐up amniocentesis are necessary in such cases.MethodsCVS was performed at 10–12 weeks of gestation. Chromosome analysis of chorionic villi was performed by standard G‐banding techniques.ResultsMosaicism of chromosome 10q11.2 deletion was observed in 24 out of 6063 CVS cases (0.39%). A common fragile site, FRA10G is located at the breakpoint region. The level of mosaicism ranged from 4% to 25%. No evidence of mosaic 10q11.2 deletion was found in follow‐up amniocentesis, maternal peripheral blood cells, or from cytogenetic studies of other pregnancies from the same group of patients. All these cases resulted in the live birth of normal healthy infants.ConclusionThe presence of del(10)(q11.2) mosaicism in chorionic villus specimens most likely represents an in vitro culture artifact due to FRA10G fragile site in this region without any clinical consequences. If ultrasound results are normal, it is not necessary to perform follow‐up amniocenteses and additional laboratory work‐up for such cases. © 2012 John Wiley & Sons, Ltd.