bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frozen storage procedures for salmon and plaice samples: Nutrient composition and implications for preservation
Authors: Oveland Eystein , Bøkevoll Annbjørg , Araujo Pedro , Hemre Gro‐Ingunn 
Published: July 2024

AbstractWe hypothesized that removing water from fish muscle homogenate by freeze‐drying might be a cost‐effective way to stabilize nutrients and allow higher temperatures for long‐term frozen storage prior to analytical measurements. To test our hypothesis, fish muscle fillets from lipid‐rich farmed Atlantic salmon (n = 5) and lean wild‐caught European plaice (n = 5) were homogenized and fresh‐frozen at −20 and −80°C. A subset of these samples was freeze‐dried prior to further frozen storage at the respective temperatures. Using validated methods, vitamins, amino acids, and fatty acids were measured after a short time of storage (starting point) and up to 1 year (endpoint), with intermediate analytical checkpoints of 1, 3, and 6 months. Trends in the degradation of certain nutrients during the different frozen storage conditions are discussed. In general, by freeze‐drying fish homogenate samples prior to frozen storage at −20°C for up to 1 year, amino acids, vitamins, and fatty acids were stabilized in both salmon and plaice when compared to wet‐frozen storage of the same samples, and storage at −80°C did not improve preservation of the freeze‐dried samples. For wet‐frozen samples, −80°C would be recommended for 1‐year storage of fillet homogenate samples, even though several nutrients preserved well at −20°C.Practical ApplicationWe present individual nutrient stability profiles in muscle homogenates from fatty fish (salmon) and lean fish (plaice) during different frozen storage conditions over time. Based on these data, freeze‐drying followed by frozen storage at −20°C for at least 1 year could be applied prior to analyses of amino acids, fat‐soluble vitamins, water‐soluble vitamins, and fatty acids. Of note is that freeze‐drying followed by frozen storage before analysis led to slightly increased measurements of several fatty acids in plaice samples, possibly attributable to an increase in dry weight or an enhancement in extraction efficiency through freeze‐drying.
Clinical reasoning and clinical judgment in nursing research: A bibliometric analysis
Authors: Doyon Odette , Raymond Louis 
Published: July 2024

AbstractAimsTo characterize the thematic foci, structure, and evolution of nursing research on clinical reasoning and judgment.DesignBibliometric analysis.MethodsWe used a bibliometric method to analyze 1528 articles.Data sourceWe searched the Scopus bibliographic database on January 7, 2024.ResultsThrough a keyword co‐occurrence analysis, we found the most frequent keywords to be clinical judgment, clinical reasoning, nursing education, simulation, nursing, clinical decision‐making, nursing students, nursing assessment, critical thinking, nursing diagnosis, patient safety, nurses, nursing process, clinical competence, and risk assessment. The focal themes, structure, and evolution of nursing research on clinical reasoning and judgment were revealed by keyword mapping, clustering, and time‐tracking.ConclusionBy assessing key nursing research areas, we extend the current discourse on clinical reasoning and clinical judgment for researchers, educators, and practitioners. Critical challenges must still be met by nursing professionals with regard to their use of clinical reasoning and judgment within their clinical practice. Further knowledge and comprehension of the clinical reasoning process and the development of clinical judgment must be successfully translated from research to nursing education and practice.Implications for the professionThis study highlights the nursing knowledge gaps with regard to nurses’ use of clinical reasoning and judgment and encourages nursing educators and professionals to focus on developing nurses’ clinical reasoning and judgment with regard to their patients’ safety.ImpactIn addressing nurses’ use of clinical reasoning and judgment, and with regard to patient safety in particular, this study found that, in certain clinical settings, the use of clinical reasoning and judgment remains a challenge for nursing professionals. This study should thus have an effect on nursing academics’ research choices, on nursing educators’ teaching practices, and on nurses’ clinical practices.Reporting methodRelevant EQUATOR guidelines have been adhered to by employing recognized bibliometric reporting methods.
Incidence, clinical classification and risk factors of cyclosporin A‐induced liver injury in allogeneic haematopoietic stem cell transplant recipients
Authors: Lv Binbin , Wang Yuqi , Xu Xueyin , Zheng Yifan , Huang Min , Chen Xiao , Tang Kejing , Li Jingjie , Chen Pan 
Published: July 2024

AbstractAimsThere is limited real‐world data on cyclosporin A (CsA)‐induced liver injury (CILI). This study aims to investigate the incidence, clinical classification and risk factors of CILI, thereby providing evidence to inform the treatment of CILI.MethodsInpatients receiving haematopoietic stem cell transplantation (HSCT) and treated with CsA were included. Patient information was collected to assess suspicious CILI by the Roussel Uclaf causality assessment method (RUCAM) scale. We evaluated the pattern and severity of CILI. The independent risk factors of CILI were identified by multivariable logistic regression.ResultsA total of 216 allogeneic HSCT (allo‐HSCT) recipients were included in this study. The incidence of CILI was 15.3% (95% confidence interval [CI]: 10.4%–20.1%). Among these cases, 84.8% displayed a hepatocellular pattern, and 90.9% of CILI was of mild severity. Baseline alanine aminotransferase (ALT) level (OR = 1.030, 95% CI: 1.008–1.053, P = .008) and trough concentration level of CsA (OR = 1.007, 95% CI: 1.002–1.012, P = .009) were identified as independent risk factors for CILI.ConclusionsThe incidence of CILI in allo‐HSCT recipients is notably high. Recipients with elevated baseline ALT levels and higher exposure to CsA are more susceptible to developing CILI.
The molecular mechanism underlying KRAS regulation on STK31 expression in pancreatic ductal adenocarcinoma
Authors: Liu Yuting , Tang Shing Chun , Li Chi Han , To Ka Fai , Li Bo , Chan Stephen Lam , Wong Chi Hin , Chen Yangchao 
Published: July 2024

AbstractKRAS gene mutations are common in pancreatic ductal adenocarcinoma (PDAC), but targeting mutant KRAS is still challenging. Here, an endoribonuclease‐prepared small interfering RNA (esiRNA) library was used to screen new kinases that play critical roles in PDAC driven by KRAS gene mutations, and serine/threonine kinase 31 (STK31) was identified and characterized as a potential therapeutic target for KRAS‐mutant PDAC. Our results showed that STK31 was upregulated in KRAS‐mutant PDAC patients with poor survival and highly expressed in PDAC cell lines with KRASG12D mutation. Inhibition of STK31 in KRAS‐mutant cell lines significantly reduced PDAC cell growth in vitro and hindered tumor growth in vivo. Gain and loss of function experiments revealed that STK31 is a downstream target of KRAS in PDAC. A pharmacological inhibition assay showed MAPK/ERK signaling involved in STK31 regulation. The further mechanistic study validated that c‐Jun, regulated by KRAS/MAPK signaling, directly modulates the transcription level of STK31 by binding to its promoter region. Through RNA sequencing, we found that the cell cycle regulators CCNB1 and CDC25C are downstream targets of STK31. Taken together, our results indicate that STK31, which is the downstream target of the KRAS/MAPK/ERK/c‐Jun signaling pathway in KRAS‐mutant PDAC, promotes PDAC cell growth by modulating the expression of the cell cycle regulators CCNB1 and CDC25C.
Poor Industry Conditions as an External Disciplining Mechanism in Takeovers
Authors: Fidrmuc Jana P. , Tykvová Tereza 
Published: July 2024

ABSTRACTResearch Question/IssueMany mergers destroy shareholder value because managers waste corporate resources to pursue private benefits. This paper considers poor conditions in the acquirer industry as a novel external disciplining mechanism that mitigates agency problems in takeovers.Research Findings/InsightsUsing textual analysis, we build a new measure of industry conditions based on acquirer peers' 10‐K statements. We link this measure to acquirer announcement abnormal returns and find that more negative industry conditions are associated with higher abnormal returns.Theoretical/Academic ImplicationsOur results suggest that poor industry conditions impose discipline on managers who then tend to focus on deals that create value for acquirer shareholders.Practitioner/Policy ImplicationsShareholders can rely on better alignment of interests with their managers during poorer industry conditions.
The W‐ICAD model: Redefining museum access through the Workshop for Inclusive Co‐created Audio Description
Authors: Eardley Alison F. , Jones Vanessa E. , Bywood Lindsay , Thompson Hannah , Husbands Deborah 
Published: July 2024

AbstractThis research describes the development of the Workshop for Inclusive Co‐created Audio Description (W‐ICAD) model. Research from psychology and neuroscience explains why the assumption that vision is necessarily sufficient to be able to engage with collections is problematic, and why inclusive museum audio description (AD) (referred to as visual or verbal description in the United States) might begin to provide a solution to this problem. At the same time, the growing recognition of the need to diversify voices and narratives within the international museum sector demands a re‐imagining of how museum AD is created, and who creates it. Underpinned by the axioms of Blindness Gain and created through an iterative action research process by a joint UK‐US team of researchers and museum professionals, in collaboration with a broader team of co‐creators, the W‐ICAD model provides museums and the cultural sector with a tool for producing co‐created AD, created by blind, partially blind and sighted individuals for use in museums by blind, partially blind or sighted audiences. The applications for this model are discussed.
Electroacupuncture alleviates myocardial ischemia–reperfusion injury by inhibiting hypothalamic paraventricular nucleus neurons projecting to the rostral ventrolateral medulla
Authors: Shu Qi , Zhou Jie , Zhang Bin , Zhang Fan , Zhou Xiang , Wu Yan , Chang Huimin , Hu Ling , Cai Ronglin , Yu Qing 
Published: July 2024

AbstractAccumulating evidence suggests that electroacupuncture (EA) has obvious therapeutic effects and unique advantages in alleviating myocardial ischemia–reperfusion injury (MIRI), while the underlying neuromolecular mechanisms of EA intervention for MIRI have not been fully elucidated. The aim of the study is to investigate the role of the neural pathway of hypothalamic paraventricular nucleus (PVN) neurons projecting to the rostral ventrolateral medulla (RVLM) in the alleviation of MIRI rats by EA preconditioning. MIRI models were established by ligating the left anterior descending coronary artery for 30 min followed by reperfusion for 2 h. Electrocardiogram recording, chemogenetics, enzyme‐linked immunosorbent assay, multichannel physiology recording and haematoxylin–eosin and immunofluorescence staining methods were conducted to demonstrate that the firing frequencies of neurons in the PVN and the expression of c‐Fos decreased by EA pretreatment. Meanwhile, EA preconditioning significantly reduced the levels of creatine kinase isoenzymes (CK‐MB), cardiac troponin I (cTnI) and lactic dehydrogenase (LDH). Virus tracing showed a projection connection between PVN and RVLM. The inhibition of the PVN‐RVLM neural pathway could replicate the protective effect of EA pretreatment on MIRI rats. However, the activation of the pathway weakened the effect of EA preconditioning. EA pretreatment alleviated MIRI by regulating PVN neurons projecting to RVLM. This work provides novel evidence of EA pretreatment for alleviating MIRI.
Anticipating the winds of change: A baseline assessment of Northeastern US continental shelf surficial substrates
Authors: Stokesbury Kevin D. E. , Bethoney N. David , Restrepo Felipe , Harris Bradley P. 
Published: July 2024

AbstractThe introduction of thousands of wind turbines along the North American Atlantic continental shelf over the next decade will constitute the largest regional change in marine substrates since the retreat of the Laurentide Ice Sheet over 14,000 years ago. Here, two large data sets, SMAST drop camera survey (242,949 samples, 2003 to 2019) and the US Geological Survey databases (27,784 samples, 1966 to 2011), are combined to derive sea floor surficial substrate probability maps for the Northeastern US continental shelf from Virginia Beach to the Gulf of Maine to 300 m depth (218,571 km2). Geostatistical models were used to estimate the probability of five geologic and one biogenic substrate types being present at a 250 m resolution, and the proportional contribution of each substrate type to the seabed composition at a 500 m resolution. By providing the first synoptic maps depicting the probability of a particular substrate or combination of substrates occurring at any location on the Northeastern US continental shelf, including planned wind energy sites, we aim to (1) provide insights regarding how substrates in the areas selected for wind energy development compare with other locations, (2) motivate the development of a priori expectations for ecosystem changes to inform monitoring and research efforts going forward, and (3) to provide a baseline characterization of the Northeastern US continental shelf surficial substrates to support robust examination of the future changes observed in areas impacted by wind energy installations.
Relational dynamics under close supervision: Examining transnational cooperation in regulatory oversight
Authors: Bravo‐Laguna Carlos , Levi‐Faur David 
Published: July 2024

AbstractThe increasing institutionalization of regulatory oversight worldwide has not resulted in the creation of numerous formal channels of transnational regulatory oversight cooperation. Despite its puzzling nature, this circumstance has barely attracted scholarly attention. Additionally, the study of cooperation across transgovernmental regulatory networks with actors having low autonomy from central governments remains under‐researched. We fill these literature gaps by applying insights from the policy networks literature to identify drivers of transnational regulatory oversight cooperation. Combining Exponential Random Graph Models with semi‐structured interviews, we show that commonalities in administrative traditions drive cooperation. Innovative bodies become sources of best practices. Conversely, exchanges between countries with similar regulatory oversight settings or preferences are rare, perhaps due to their low independence from their political principals. These results suggest that regulatory oversight actors use relational opportunities and general country features as cues for transnational cooperation, instead of adopting strategic partnerships with better matches.
Improved survival outcome of curative liver resection for Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma in the era of tyrosine kinase inhibitors
Authors: Asahi Yoh , Kakisaka Tatsuhiko , Kamiyama Toshiya , Orimo Tatsuya , Shimada Shingo , Nagatsu Akihisa , Aiyama Takeshi , Sakamoto Yuzuru , Wakizaka Kazuki , Shichi Shunsuke , Kamachi Hirofumi , Taketomi Akinobu 
Published: July 2024

AbstractAimThis study was undertaken to evaluate the outcome of curative liver resection, (LR) of Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma (BCLC‐C HCC) after tyrosine kinase inhibitors (TKIs) became approved as a treatment option for recurrent lesions.MethodsSixty‐seven patients with BCLC‐C HCC who underwent curative LR were enrolled in this study. The patients were classified into two groups according to whether LR was performed before (n = 24) or after (n = 43) TKI approval (“beforeTKI” and “afterTKI” group, respectively).ResultsThere was no difference in the median disease‐free survival time after LR between the beforeTKI and afterTKI groups (5.6 and 7.1 months, respectively; p = 0.435). However, the median survival time after LR was longer in the afterTKI than beforeTKI group (42.7 and 14.9 months, respectively; p = 0.022). Univariate and multivariate analyses showed that the date of LR was the only independent factor affecting postresection survival. When the patients were limited to those with recurrence, there were no differences in the recurrence pattern or progression of HCC at the time of recurrence between the two groups. The only difference in the treatment distribution was the administration of TKIs (14 of 34 patients in afterTKI group and only 1 of 19 patients in beforeTKI group, p < 0.001).ConclusionThese data suggest that TKI therapy for recurrent BCLC‐C HCC is associated with improved overall survival. Thus, LR could be a promising option for BCLC‐C HCC in the current era of TKI therapy.
Effect of butylated hydroxyanisole and α‐tocopherol on the oxidative stability of palm olein during microwave heating
Authors: How Yu Hsuan , Nyam Kar Lin , Soo Wei Xin 
Published: July 2024

SummaryThe consumption of oxidised oil had been linked with health issues such as heart diseases, neurodegenerative diseases, and cancer. This study aimed to evaluate the effect of natural and synthetic antioxidants on palm olein during microwave heating. The microwave heating of palm olein with or without antioxidants (butylated hydroxyanisole (BHA) and α‐tocopherol) was conducted at 300, 600, and 1000 W for 1, 3, and 5 min and analysed. Palm olein with α‐tocopherol displayed the lowest conjugated diene (<0.98) and conjugated triene (<0.65) than palm olein. The presence of α‐tocopherol showed higher or comparable oxidative stability (4.88 para‐anisidine value, 13.76 total oxidation value) against BHA in palm olein during microwave heating. The high oxidation stability of microwave‐heated palm olein with α‐tocopherol demonstrated its potential as a natural antioxidant substitution from synthetic antioxidant. The palm olein with α‐tocopherol could be further evaluated through repeated microwave heating.
Coffee fermentation as a tool for quality improvement: an integrative review and bibliometric analysis
Authors: Silva Marcelo Edvan dos Santos , de Oliveira Rodrigo Lira , de Lucena Rodrigo Mendonça , da Silva Suzana Pedroza , Porto Tatiana Souza 
Published: July 2024

SummaryFermentation has been studied to improve the chemical composition and sensory profile of coffee, of interest to the food industry and farmers seeking competitiveness in the international market. This study addresses the influence of biotransformation on the synthesis of flavour precursor compounds and correlates subsequent processes, such as roasting, and chemical mechanisms responsible for the formation of coffee's sensory profiles. The results indicate that coffee fermentation contributes to the formation of precursor metabolites of volatile compounds and the different fermentation techniques favour the production of high‐quality coffee. Bibliometrics analysis from 2012 to 2022 highlighted Brazil and China with a high number of research, scientific collaborations, and international cooperation, indicating a current trend in research focused on sensory modulation. Fermentation technologies point to a promising scenario with the possibility of producing coffee with previously defined sensory characteristics. This market is in full development and corroborates the growing pace of coffee consumption.
Effects of boiling, centrifuging and drying methods on bioactive compounds in Antarctic krill meal
Authors: Yang Liu , Zheng Yao , Zhang Shuaishuai , Wang Xin , Guo Quanyou 
Published: July 2024

SummaryBoiling, centrifuging and various drying techniques (vacuum freeze‐drying (VFD), vacuum drying (VD), hot‐air drying (HAD) and microwave drying (MWD)) were assessed for their impact on bioactive compounds in Antarctic krill meal. A comparison between the raw and boiling groups revealed a significant degradation and isomerisation of astaxanthin, accompanied by a 1.25‐fold and 1.32‐fold increase in saturated (SFAs) and monounsaturated fatty acids (MUFAs), respectively. Drying was the primary factor responsible for the reduction in phospholipids, α‐tocopherol and polyunsaturated fatty acid (PUFAs), in combination with the increase in thiobarbituric acid‐reactive substances. For different drying methods, it was found that HAD induced severe lipid oxidation. In contrast, the VFD, VD and MWD improved lipid quality, reducing thiobarbituric acid‐reactive substances (TBARS) by 13–22% and increasing phospholipids by 1.08–1.11 times compared to HAD. VD preserved higher levels of bioactive compounds. PLS‐DA analysis identified 13‐cis‐astaxanthin, α‐tocopherol and eleven fatty acids as key indicators for Antarctic krill meal.
Birth Patterns in the Aftermath of the 1918 Influenza Pandemic in India: The Case of Madras City
Authors: Chandra Siddharth , Sarkar Rajiv , Rynjah Banseilang 
Published: July 2024

ABSTRACTThis paper examines the timing of one‐time fluctuations in births subsequent to the 1918 influenza pandemic in Madras (now Chennai), India. After seasonally decomposing key demographic aggregates, we identified abrupt one‐time fluctuations in excess births, deaths, and infant deaths. We found a contemporaneous spike in excess deaths and infant deaths and a 40‐week lag between the spike in deaths and a subsequent deficit in births. The results suggest that India experienced the same kind of short‐term postpandemic “baby bust” that was observed in the United States and other countries. Identifying the mechanisms underlying this widespread phenomenon remains an open question and an important topic for future research.
Two‐stage pricing of products and services considering different competitive environments
Authors: Qi Wei , Li Ziwei , Liu Xuwang 
Published: July 2024

AbstractDesigning a product line that considers value‐added services (VASs) is a strategic move for enterprises with diversified customer needs. Additionally, a dynamic pricing strategy that can respond to changes in the external environment is crucial for enterprises. This study investigates product and VAS price adjustments for enterprises in monopolistic and oligopolistic competitive environments, respectively, based on the multinomial logit model. A two‐stage pricing model is developed for products and services to obtain the optimal pricing strategy. The findings reveal that customers’ strategic behaviors significantly impact on enterprises’ pricing decisions. When adjusting prices, enterprises need to consider the strategic behaviors of customers to ensure the rationality of pricing. Furthermore, irrespective of the competitive environment faced by enterprises, there is a need to emphasize the importance of dynamic pricing. Making appropriate adjustments to prices in the second stage can, overall, enhance the profitability of the enterprise.