bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neighborhood Factors Associated with Time to Resolution Following an Abnormal Breast or Cervical Cancer Screening Test
Authors: Plascak Jesse J. , Llanos Adana A. , Pennell Michael L. , Weier Rory C. , Paskett Electra D. 
Published: September 2014

Abstract
Background: The effect of neighborhood and healthcare access factors on cancer outcomes among patients enrolled in navigator programs is not clearly understood. This study assessed associations between: (i) neighborhood factors and diagnostic time to resolution (TTR) and (ii) geographic access and TTR following an abnormal breast or cervical cancer screening test among women participating in the Ohio Patient Navigator Research Program (OPNRP).
Methods: Patient (demographic, socioeconomic status, home-to-clinic distance) and neighborhood (deprivation, racial segregation) characteristics of 801 women living in one of 285 census tracts (CT) in greater Columbus, Ohio were examined. Randomization to receive navigation occurred at the clinic level. Multilevel Cox regression and spatial analysis were used to estimate effects of various factors on TTR and assess model assumptions, respectively.
Results: TTR increased as neighborhood deprivation increased. After adjustment for age, friend social support, education, and healthcare status, the TTR among women living in a neighborhood with a moderate median household income (between $36,147 and $53,099) was shorter compared with women living in low median household income neighborhoods (&lt;$36,147; P &lt; 0.05). There is little evidence that unmeasured confounders are geographically patterned.
Conclusions: Increased neighborhood socioeconomic deprivation was associated with longer TTR following an abnormal breast or cervical cancer screening test.
Impact: These results highlight the need for addressing patient- and neighborhood-level factors to reduce cancer disparities among underserved populations. Cancer Epidemiol Biomarkers Prev; 23(12); 2819–28. ©2014 AACR.
Novel Selective Estrogen Mimics for the Treatment of Tamoxifen-Resistant Breast Cancer
Authors: Molloy Mary Ellen , White Bethany E. Perez , Gherezghiher Teshome , Michalsen Bradley T. , Xiong Rui , Patel Hitisha , Zhao Huiping , Maximov Philipp Y. , Jordan V. Craig , Thatcher Gregory R.J. , Tonetti Debra A. 
Published: September 2014

Abstract
Endocrine-resistant breast cancer is a major clinical obstacle. The use of 17β-estradiol (E2) has reemerged as a potential treatment option following exhaustive use of tamoxifen or aromatase inhibitors, although side effects have hindered its clinical usage. Protein kinase C alpha (PKCα) expression was shown to be a predictor of disease outcome for patients receiving endocrine therapy and may predict a positive response to an estrogenic treatment. Here, we have investigated the use of novel benzothiophene selective estrogen mimics (SEM) as an alternative to E2 for the treatment of tamoxifen-resistant breast cancer. Following in vitro characterization of SEMs, a panel of clinically relevant PKCα-expressing, tamoxifen-resistant models were used to investigate the antitumor effects of these compounds. SEM treatment resulted in growth inhibition and apoptosis of tamoxifen-resistant cell lines in vitro. In vivo SEM treatment induced tumor regression of tamoxifen-resistant T47D:A18/PKCα and T47D:A18-TAM1 tumor models. T47D:A18/PKCα tumor regression was accompanied by translocation of estrogen receptor (ER) α to extranuclear sites, possibly defining a mechanism through which these SEMs initiate tumor regression. SEM treatment did not stimulate growth of E2-dependent T47D:A18/neo tumors. In addition, unlike E2 or tamoxifen, treatment with SEMs did not stimulate uterine weight gain. These findings suggest the further development of SEMs as a feasible therapeutic strategy for the treatment of endocrine-resistant breast cancer without the side effects associated with E2. Mol Cancer Ther; 13(11); 2515–26. ©2014 AACR.
Associations Between Anticoagulation Therapy and Risks of Mortality and Readmission Among Patients With Heart Failure and Atrial Fibrillation
Authors: Hernandez Adrian F. , Liang Li , Fonarow Gregg C. , Hammill Bradley G. , Hammill Stephen C. , Heidenreich Paul A. , Masoudi Frederick A. , Qualls Laura G. , Al-Khatib Sana M. , Piccini Jonathan P. , Curtis Lesley H. 
Published: September 2014

Background—
Patients with heart failure and atrial fibrillation are at higher risk of thromboembolic events than patients with heart failure alone. Yet, the use of anticoagulation therapy varies in clinical practice, especially among older patients, for whom its effectiveness is poorly understood.

Methods and Results—

Using clinical registry data linked to Medicare claims from 2005 to 2011, we examined outcomes of older patients hospitalized with heart failure and atrial fibrillation who newly initiated anticoagulation therapy at discharge. We used Cox proportional hazards models and inverse probability-weighted treatment estimates to adjust for selection bias. Main outcomes were mortality and readmission at 1 and 3 years. Among 5105 patients in 195 hospitals, 1623 (31.8%) started anticoagulation therapy at discharge. Treated patients had lower unadjusted rates of all-cause mortality (26.4% versus 42.8%;
P
<0.001) and all-cause readmission (58.4% versus 63.7%;
P
<0.001) at 1 year. After inverse weighting for the probability of treatment and adjustment for other discharge medications, anticoagulation therapy was associated with significantly lower 1-year mortality (hazard ratio, 0.70; 99% confidence interval, 0.59–0.82), but there was no statistically significant difference in the risk of all-cause readmission (hazard ratio, 0.89; 99% confidence interval, 0.78–1.01) or other readmission outcomes. Results were similar at 3 years.

Conclusions—
Initiation of anticoagulation therapy at hospital discharge was associated with improved mortality at 1 and 3 years but was not associated with improved cardiovascular readmission among older patients with heart failure and atrial fibrillation.
Association Between Success Rate and Citation Count of Studies of Radiofrequency Catheter Ablation for Atrial Fibrillation
Authors: Perino Alexander C. , Hoang Donald D. , Holmes Tyson H. , Santangeli Pasquale , Heidenreich Paul A. , Perez Marco V. , Wang Paul J. , Turakhia Mintu P. 
Published: September 2014

Background—
The preferential citation of studies with the highest success rates could exaggerate perceived effectiveness, particularly for treatments with widely varying published success rates such as radiofrequency catheter ablation for atrial fibrillation.

Methods and Results—

We systematically identified observational studies and clinical trials of radiofrequency catheter ablation of atrial fibrillation between 1990 and 2012. Generalized Poisson regression was used to estimate association between study success rate and total citation count, adjusting for sample size, journal impact factor, time since publication, study design, and whether first or last author was a consensus-defined pre-eminent expert. We identified 174 articles meeting our inclusion criteria (36 289 subjects). After adjustment only for time since publication, a 10-point increase above the mean in pooled reported success rates was associated with a 17.8% increase in citation count at 5 years postpublication (95% confidence interval, 7.1–28.4%;
P
<0.001). After additional adjustment for impact factor, sample size, randomized trial design, and pre-eminent expert authorship, the association remained significant (18.6% increase in citation count; 95% confidence interval, 7.6–29.6%;
P
<0.0001). In this full model, time since publication, impact factor, and pre-eminent expert authorship were significant covariates, whereas randomized control trial design and study sample size were not.

Conclusions—
Among studies of radiofrequency catheter ablation of atrial fibrillation, high success rate was independently associated with citation count, which may indicate citation bias. To readers of the literature, radiofrequency catheter ablation of atrial fibrillation could be perceived to be more effective than the data supports. These findings may have implications for a wide variety of novel cardiovascular therapies.
β-Adrenergic Receptor–Mediated Cardiac Contractility Is Inhibited via Vasopressin Type 1A-Receptor–Dependent Signaling
Authors: Tilley Douglas G. , Zhu Weizhong , Myers Valerie D. , Barr Larry A. , Gao Erhe , Li Xue , Song Jianliang , Carter Rhonda L. , Makarewich Catherine A. , Yu Daohai , Troupes Constantine D. , Grisanti Laurel A. , Coleman Ryan C. , Koch Walter J. , Houser Steven R. , Cheung Joseph Y. , Feldman Arthur M. 
Published: September 2014

Background—
Enhanced arginine vasopressin levels are associated with increased mortality during end-stage human heart failure, and cardiac arginine vasopressin type 1A receptor (V1AR) expression becomes increased. Additionally, mice with cardiac-restricted V1AR overexpression develop cardiomyopathy and decreased β-adrenergic receptor (βAR) responsiveness. This led us to hypothesize that V1AR signaling regulates βAR responsiveness and in doing so contributes to development of heart failure.

Methods and Results—

Transaortic constriction resulted in decreased cardiac function and βAR density and increased cardiac V1AR expression, effects reversed by a V1AR-selective antagonist. Molecularly, V1AR stimulation led to decreased βAR ligand affinity, as well as βAR-induced Ca
2+
mobilization and cAMP generation in isolated adult cardiomyocytes, effects recapitulated via ex vivo Langendorff analysis. V1AR-mediated regulation of βAR responsiveness was demonstrated to occur in a previously unrecognized Gq protein–independent/G protein receptor kinase–dependent manner.

Conclusions—
This newly discovered relationship between cardiac V1AR and βAR may be informative for the treatment of patients with acute decompensated heart failure and elevated arginine vasopressin.
Laryngeal Reconstruction with a Sternohyoid Muscle Flap after Supracricoid Laryngectomy: Postoperative Respiratory and Swallowing Evaluation
Authors: Yu Yue , Wang Xiao‐lei , Xu Zhen‐gang , Wu Yue‐huang 
Published: September 2014

ObjectiveTo compare postoperative respiratory and swallowing functions between patients who underwent classic supracricoid laryngectomy (SCL) and those who underwent SCL with laryngeal reconstruction using the sternohyoid muscle.Study DesignProspective study.SettingNational cancer center.Subjects and MethodsForty‐four patients who consecutively underwent SCL for laryngeal squamous cell carcinoma from December 2009 to March 2011 were included. Postoperative parameters including the mean tracheostomy decannulation time, tracheostomy decannulation rate at 6 months, mean nasogastric tube (NGT) removal time, degree of dysphagia at 3 months, and survival time after surgery were evaluated.ResultsTwenty‐one patients underwent classic SCL (group A), and 23 underwent SCL with laryngeal reconstruction (group B). After a median follow‐up period of 37 months (range, 3‐44 months), group A had a significantly longer mean decannulation time (120.05 ± 109.38 days vs 33.43 ± 22.60 days, respectively; P <. 01) and NGT removal time (37.30 ± 29.97 days vs 17.22 ± 10.95 days, respectively; P <. 01) than group B. Swallowing function after 6 months was significantly better in group B than in group A (P =. 004). The decannulation rate after 6 months was significantly higher in group B than in group A (95.7% vs 66.7%, respectively; P =. 036). The 3‐year disease‐free survival rate was not significantly different between group A and group B (95.2% vs 95.7%, respectively; P =. 961).ConclusionLaryngeal reconstruction using a sternohyoid muscle flap seems to improve quality of life in the early postoperative period after SCL.
Ibuprofen with Acetaminophen for Postoperative Pain Control following Tonsillectomy Does Not Increase Emergency Department Utilization
Authors: Bedwell Joshua R. , Pierce Matthew , Levy Michelle , Shah Rahul K. 
Published: September 2014

ObjectiveTo compare the performance of ibuprofen vs codeine for postoperative pain management after tonsillectomy as measured by need for emergency department (ED) treatment for pain and/or dehydration.Study DesignRetrospective case series with chart review.SettingTertiary children's hospital.Subjects and MethodsConsecutive series of patients who underwent tonsillectomy with or without adenoidectomy at a tertiary children's hospital. Patients were categorized based on the type of postoperative pain management (acetaminophen with codeine vs acetaminophen and ibuprofen). The main outcome measure was the proportion of patients requiring ED visits or inpatient admissions for inadequate pain control or dehydration. Secondary measures included antibiotic use, postoperative hemorrhage, need for return to the operating room, vomiting, and oral diet tolerance.ResultsPatients in the ibuprofen/acetaminophen group were younger than those in the codeine/acetaminophen group (6.2 vs 8.1 years, P <. 05). Patients in the codeine/acetaminophen group were more likely to use antibiotics in the postoperative period (50.3% vs 5.9%, P <. 05). The proportion of patients requiring ED visits or inpatient admission for dehydration was not significantly different between the groups (5.1% for codeine, 2.7% for ibuprofen, P =. 12). Multivariable analysis controlling for age and antibiotic use showed no difference in ED visits or admission for dehydration (P =. 09). There was no difference between the groups for any of the secondary measures.ConclusionsIbuprofen with acetaminophen represents a safe and acceptable analgesic alternative to codeine and acetaminophen in patients undergoing pediatric tonsillectomy.
MiR-146a regulates the TRAF6/TNF-axis in donor T cells during GVHD
Authors: Stickel Natalie , Prinz Gabriele , Pfeifer Dietmar , Hasselblatt Peter , Schmitt-Graeff Annette , Follo Marie , Thimme Robert , Finke Jürgen , Duyster Justus , Salzer Ulrich , Zeiser Robert 
Published: September 2014

Key Points
This study deciphers the regulatory role of miR-146a during GVHD in mice. In humans, the minor genotype of the SNP rs2910164, which reduces expression of miR-146a, was associated with higher GVHD severity.
Three-dimensional inversion of magnetotelluric data from the Central Andean continental margin
Authors: Kühn Christine , Küster Jonas , Brasse Heinrich 
Published: September 2014

Abstract
Magnetotelluric data were collected in the late 1990s in the Central Andes of Chile and Bolivia, with the aim to delineate the electrical conductivity distribution in the subsurface and its relations to subduction processes. In previous studies, these data were interpreted based on 2-D models. The principal result was a vast conductivity zone beneath the Altiplano high plateau at mid and lower crustal depths and a much smaller, though significant conductor associated with the Precordillera Fault System. However, there are some significant 3-D effects in the investigation area, in particular near the coast and on the eastern Altiplano. The aim of this work is to give a reinterpretation based on new 3-D inversion of these data. The 3-D inversion not only provides a better fit to the data compared to 2-D results but furthermore allows to include sites with strong telluric distortion which were ignored in previous studies. We are now able to explain anomalous phases above 90° and induction arrows pointing subparallel to the coast as observed at several sites in the Coastal Cordillera. These strongly distorted data are caused by highly conductive near-surface structures that are partly connected to the Pacific Ocean, forcing currents to flow around the sites. The lower crust beneath the Coastal Cordillera resembles a poorly conductive, nearly homogeneous half-space and is electrically unremarkable. Besides, we can now image the Precordillera conductor as a continuous, elongated feature. The volcanic arc of the Western Cordillera is highly resistive with the exception of a few conductive spots which may be associated with certain individual volcanoes or geothermal resources, respectively. The Altiplano conductor is again the dominant electrical feature in the Central Andes, indicating widespread melting of the middle and lower back-arc crust.
Erythropoietin and organ protection: lessons from negative clinical trials
Authors: Pearl Ronald G 
Published: September 2014

AbstractBased on its pleiotropic effects, erythropoietin can decrease inflammation, oxidative stress, and apoptosis. Erythropoietin provides organ protection for the heart, brain, and kidney in diverse preclinical animal studies, especially models that include ischemia-reperfusion injury and/or inflammation. However, large clinical studies in coronary reperfusion, heart failure, stroke, acute kidney injury, and chronic renal disease have failed to demonstrate improved outcomes. A study in a previous issue of Critical Care examining the ability of erythropoietin to prevent or ameliorate acute kidney injury in patients undergoing complex valvular heart surgery is similarly negative. The failure of erythropoietin in clinical studies may be due to an inadequate dose, since the receptors responsible for organ protection may require higher concentrations than those responsible for erythropoiesis. However, as has occurred in studies in sepsis and acute respiratory distress syndrome, the negative studies probably reflect an inadequate understanding of the complexity of the underlying processes with multiple redundant and interacting pathways that may differ among the large number of different cell types involved. As tools to understand this complexity and integrate it on an organismal basis continue to evolve, we will develop the ability to use erythropoietin and related nonhematopoietic agents for organ protection.
Enhanced monocyte chemoattractant protein-1 production in aging mice exaggerates cardiac depression during endotoxemia
Authors: Slimani Hanan , Zhai Yufeng , Yousif Nasser G , Ao Lihua , Zeng Qingchun , Fullerton David A , Meng Xianzhong 
Published: September 2014

Abstract
Introduction
Endotoxemia and the systemic inflammatory response syndrome have a significant impact on post-surgery outcome, particularly in the elderly. The cytokine response to endotoxin is altered by aging. We tested the hypothesis that vulnerability to endotoxemic cardiac depression increases with aging due to age-related augmentation of myocardial inflammatory responses.

Methods
Adult (4 to 6 months) and old (20 to 22 months) C57/BL6 mice were treated with endotoxin (0.5 mg/kg, iv). Left ventricle (LV) function was assessed using a microcatheter system. Chemokines and cytokines in plasma and myocardium were analyzed by enzyme-linked immunosorbent assay (ELISA). Mononuclear cells in the myocardium were examined using immunofluorescence staining.

Results
Old mice displayed worse LV function (cardiac output: 3.0 ± 0.2 mL/min versus 4.4 ± 0.3 mL/min in adult mice) following endotoxin treatment. The exaggerated cardiac depression in old mice was associated with higher levels of monocyte chemoattractant protein-1 (MCP-1) and keratinocyte chemoattractant (KC) in plasma and myocardium, greater myocardial accumulation of mononuclear cells, and greater levels of tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β) and interleukin 6 (IL-6) in plasma and myocardium. Neutralization of MCP-1 resulted in greater reductions in myocardial mononuclear cell accumulation and cytokine production, and greater improvement in LV function in old mice while neutralization of KC had a minimal effect on LV function.

Conclusion
Old mice have enhanced inflammatory responses to endotoxemia that lead to exaggerated cardiac functional depression. MCP-1 promotes myocardial mononuclear cell accumulation and cardiodepressant cytokines production, and plays an important role in the endotoxemic cardiomyopathy in old mice. The findings suggest that special attention is needed to protect the heart in the elderly with endotoxemia.
Mitochondrial dysfunction in some triple-negative breast cancer cell lines: role of mTOR pathway and therapeutic potential
Authors: Pelicano Hélène , Zhang Wan , Liu Jinyun , Hammoudi Naima , Dai Jiale , Xu Rui-Hua , Pusztai Lajos , Huang Peng 
Published: September 2014

Abstract
Introduction
Triple-negative breast cancer (TNBC) is a subtype of highly malignant breast cancer with poor prognosis. TNBC is not amenable to endocrine therapy and often exhibit resistance to current chemotherapeutic agents, therefore, further understanding of the biological properties of these cancer cells and development of effective therapeutic approaches are urgently needed.

Methods
We first investigated the metabolic alterations in TNBC cells in comparison with other subtypes of breast cancer cells using molecular and metabolic analyses. We further demonstrated that targeting these alterations using specific inhibitors and siRNA approach could render TNBC cells more sensitive to cell death compared to other breast cancer subtypes.

Results
We found that TNBC cells compared to estrogen receptor (ER) positive cells possess special metabolic characteristics manifested by high glucose uptake, increased lactate production, and low mitochondrial respiration which is correlated with attenuation of mTOR pathway and decreased expression of p70S6K. Re-expression of p70S6K in TNBC cells reverses their glycolytic phenotype to an active oxidative phosphorylation (OXPHOS) state, while knockdown of p70S6K in ER positive cells leads to suppression of mitochondrial OXPHOS. Furthermore, lower OXPHOS activity in TNBC cells renders them highly dependent on glycolysis and the inhibition of glycolysis is highly effective in targeting TNBC cells despite their resistance to other anticancer agents.

Conclusions
Our study shows that TNBC cells have profound metabolic alterations characterized by decreased mitochondrial respiration and increased glycolysis. Due to their impaired mitochondrial function, TNBC cells are highly sensitive to glycolytic inhibition, suggesting that such metabolic intervention may be an effective therapeutic strategy for this subtype of breast cancer cells.
The role of social networking in the life of under-age persons with special needs
Authors: Михеев Артур , Mikheev Artur 
Published: September 2014

The article present the results of research into the role of social networking in the life of under-age (aged 10–18) people with special needs (the number of respondents —120 under-age people). The aim of the research is to identify the degree of influence that social networks have on the process of social adaptation of under-age people with special needs. Each of the social networks under scrutiny was analyzed as to the user opportunities it has to offer and the user needs it can satisfy.
The author also provides a definition of (1) the concept of a social network, (2) a social graph as a major element of a social network, (3) a person with special needs, and (4) population disability.
Embroidery as an aesthetic constituent of the garment
Authors: Ефимова Людмила , Efimova Lyudmila 
Published: September 2014

The aesthetically beautiful promotes the generation and development of morals, which is demonstrated by the art of embroidery. Dating back into the ancient times, the traditions and practice of embroidery have been consistently developed and passed from master to apprentice. The author regards elements of embroidery as symbols created as a result of the philosophical and aesthetic interpretation of the world. According to the author, towel embroidery has reflected folk world outlook, thoughts and customs connected with fertility and filial piety. Beauty as a symbol originating from the spiritual reveals itself in the embroidery ornaments, which identify human life and art with eternity. Embroidery resembles nature, as neither tolerates vacuum and is always rich in aesthetics and
sense. Embroidery does not only reflect the historical and cultural development of people but is its active and direct participant.