bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and In vitro Evaluation of Pantoprazole-Sustained Release
Effervescent Floating Tablets for Effective Management of Ulcer
Authors: Virgilus Onyishi Ikechuchukwu , Amarachi Chime Salome , Elizabeth Ike-Onyishi Ugochi , Ijeoma Ndukauba , Achile Akpa Paul , Chigozie Ezeudoh Clara , Tochuchukwu Ogbonna Emmanuella 
Published: June 2024

Introduction:
Pantoprazole is a very suitable drug for the treatment of numerous
acid-related conditions in humans and mammals. Owing to its short half-life (0.9 – 1.9 h), it is
ideal for sustained release formulation.

Methods:
This study was aimed at developing pantoprazole gastroretentive (GR) controlledrelease tablets and to determine the effects of this formulation and processing parameters on
drug release and other critical quality attributes of directly compressed tablets produced using
different matrix-forming polymers, namely, Hydroxypropyl methylcellulose (HPMC), chitosan, sodium alginate, maize starch, kappa- carrageenan, and propyl vinyl pyrrolidine PVP K30 when formulated into effervescent Floating Drug Delivery Systems (FDDS).

Results:
The buoyancy lag time of less than 5 seconds and a total floating time of more than 12
hours for all batches is a good indication of achieved floatation for FDDS.

Conclusion:
Validation processes initiated with the five batches indicated that the polymer
blends had the potential for the formulation of pantoprazole FDDS and, hence, could enhance
patient compliance and better treatment outcomes due to their sustained release potentials.
Unravelling Phyto-Compound Therapeutics against SRC Protein via FGF
Pathway Targeting-A Comprehensive Approach Integrating Omics Data
Analysis, Network Pharmacology, Virtual Screening, and Molecular
Dynamics
Authors: Tripathi Pankaj Kumar , Jain Chakresh Kumar 
Published: June 2024

Introduction:
Colorectal cancer is a complex condition influenced by genetic mutations and environmental factors. Due to its intricate nature, the diagnosis and treatment of this condition require a
comprehensive approach that considers individual circumstances. The study aimed to identify genes
linked with colorectal cancer and their therapeutic agents from natural bioactive compounds.

Methods:
The significantly prognostic differentially expressed genes (DEGs) were screened out
from NCBI Gene Expression Omnibus (GEO) datasets. A protein-protein interaction network was
constructed using STRING Database, and key genes were identified using Network Analyzer and
CytoNCA plugins within Cytoscape. Further analysis involved functional annotations, and biological pathways analysis, SRC mechanism to uncover the role of SRC in CRC. Additionally, we performed virtual screening and molecular docking, Physiochemical property analysis along with MD
simulation study to propose suitable natural compounds for promising therapeutic targets.

Results:
The study conducted differential gene expression analysis, identifying 3621 statistically
significant genes, with 1467 upregulated and 2154 downregulated. The top ten genes with the highest degree, betweenness centrality, and closeness centrality in the PPI network were selected as key
genes. The SRC gene was found to have the highest degree and closeness centrality. Functional annotation and pathway analysis of key genes with a specific focus on the SRC mechanism revealed
that the SRC's role in activating the RAS-RAF-MEK-ERK and Wnt/β-catenin pathways in CRC
cells, promoting proliferation and invasion. Molecular modelling of SRC led to the screening of
phyto-compounds from tropical fruits, with Rutinexhibiting a higher docking score compared to
FDA-approved anticancer drugs. MD simulations over 100 ns and the post-MD analysis i.e. RMSD,
SASA, RMSF, FEL, RG, Hydrogen bond, PCA, and MMPBSA, comprehended the stable and robust interactions of a protein-ligand complex. These findings suggest Rutin's potential as a potent
natural molecule for treating CRC.
The study concludes that SRC plays a pivotal role in CRC, influencing cellular processes critical to
cancer development and Rutin has been found to be a promising SRC inhibitor, suggesting a potential alternative therapeutic strategy for CRC. The consistent molecular interactions of Rutin necessitate further validation through wet lab experiments, offering hope for individuals affected by CRC
Long-term results of endovascular treatment of patients with coronary heart disease using various PCI technologies
Authors: Malevannyy M. V. , Hripun A. V. , Chesnokov V. V. 
Published: June 2024

Objective: the effectiveness and safety of endovascular treatment of coronary artery disease in coronary artery disease using various technologies of percutaneous coronary intervention (PCI) was evaluated — implantation of drug-coated metal stents, implantation of bioresorbable stenting scaffolds, the use of drug-coated coronary balloon catheters in the long- term period, 10 years after PCI.Materials and methods: data obtained from 324 patients with coronary heart disease after PCI using the previously mentioned treatment methods. The endpoint was the loss of the target vessel lumen (TLF), a combination of cardiac death, myocardial infarction, and revascularization associated with the target vessel.Results: the treatment of patients with coronary heart disease using implantation of drug-coated metal stents, bioresorbable stenting scaffolds or drug-coated coronary balloon catheters is safe and has low rates of cardiac mortality, myocardial infarction and revascularization of the target vessel in the long term. In cases where implantation of stents or scaffolds was contraindicated or impossible due to the small diameter of the artery, diffuse extended lesion and high risk of restenosis, angioplasty with a coronary balloon catheter with an antiproliferative drug coating takes place, showing positive long-term results.
Między filozofią a światopoglądem. Myśl społeczna i religijna Józefa M. Bocheńskiego w kontekście sporów ideowych w XX wieku
Authors: Kroczek Piotr 
Published: June 2024

The monograph “Between Philosophy and Worldview: The Social and Religious Thought of Józef M. Bocheński in the Context of Ideological Disputes in the 20th Century” by Piotr Kroczek offers a comprehensive analysis of the intellectual legacy of one of Poland’s most prominent philosophers of the 20th century. The work focuses on the social and religious aspects of Bocheński’s thought, which he developed in the context of the major events and ideological disputes of his era, such as the two World Wars, the rise and spread of communism, and the Second Vatican Council. Kroczek presents Bocheński not only as a theoretician but also as an active participant in these events, providing deeper insight into how his experiences shaped his views. The monograph details how this Dominican used the analytical method to examine issues related to war, peace, democracy, communism, religion, the Catholic Church, clergy, university, economy, law, and justice. Kroczek draws on an extensive source base, including Bocheński’s original texts and numerous studies and commentaries, to thoroughly present and critically assess his thoughts. The author highlights the importance of precision and rigor in Bocheński’s work, particularly his emphasis on logic and linguistic analysis, which were crucial tools for him in seeking truth and debunking superstitions. The monograph also includes comparisons of Bocheński’s thought with other prominent philosophers and an analysis of the impact of his views on contemporary philosophical debates. Kroczek argues that despite the passage of time, many of Bocheński’s reflections remain relevant and can serve as valuable sources of inspiration for addressing contemporary social and philosophical issues. The monograph is not only a tribute to Bocheński’s intellectual heritage but also an invitation for further research into his work. Kroczek underscores the need for a critical approach to Bocheński’s thought, encouraging its creative development and adaptation to modern realities. In conclusion, the monograph “Between Philosophy and Worldview…” is a comprehensive study that portrays Bocheński as a thinker with broad horizons, capable of deep analyses and bold polemics, while also highlighting that his ideas still have much to offer to the contemporary world.
The Impact of Collaborative Documentation on Person-Centered Care: Textual Analysis of Clinical Notes
Authors: Stanhope Victoria , Yoo Nari , Matthews Elizabeth , Baslock Daniel , Hu Yuanyuan 
Published: June 2024

Abstract

Background
Collaborative documentation (CD) is a behavioral health practice involving shared writing of clinic visit notes by providers and consumers. Despite widespread dissemination of CD, research on its effectiveness or impact on person-centered care (PCC) has been limited. Principles of PCC planning, a recovery-based approach to service planning that operationalizes PCC, can inform the measurement of person-centeredness within clinical documentation.

Objective
This study aims to use the clinical informatics approach of natural language processing (NLP) to examine the impact of CD on person-centeredness in clinic visit notes. Using a dictionary-based approach, this study conducts a textual analysis of clinic notes from a community mental health center before and after staff were trained in CD.

Methods
This study used visit notes (n=1981) from 10 providers in a community mental health center 6 months before and after training in CD. LIWC-22 was used to assess all notes using the Linguistic Inquiry and Word Count (LIWC) dictionary, which categorizes over 5000 linguistic and psychological words. Twelve LIWC categories were selected and mapped onto PCC planning principles through the consensus of 3 domain experts. The LIWC-22 contextualizer was used to extract sentence fragments from notes corresponding to LIWC categories. Then, fixed-effects modeling was used to identify differences in notes before and after CD training while accounting for nesting within the provider.

Results
Sentence fragments identified by the contextualizing process illustrated how visit notes demonstrated PCC. The fixed effects analysis found a significant positive shift toward person-centeredness; this was observed in 6 of the selected LIWC categories post CD. Specifically, there was a notable increase in words associated with achievement (β=.774, P<.001), power (β=.831, P<.001), money (β=.204, P<.001), physical health (β=.427, P=.03), while leisure words decreased (β=−.166, P=.002).

Conclusions
By using a dictionary-based approach, the study identified how CD might influence the integration of PCC principles within clinical notes. Although the results were mixed, the findings highlight the potential effectiveness of CD in enhancing person-centeredness in clinic notes. By leveraging NLP techniques, this research illuminated the value of narrative clinical notes in assessing the quality of care in behavioral health contexts. These findings underscore the promise of NLP for quality assurance in health care settings and emphasize the need for refining algorithms to more accurately measure PCC.
Systematic Literature Review: Faktor yang Berhubungan dengan Kepatuhan Peserta PBPU dalam Membayar Iuran JKN
Authors: Tsuroyya Sabrina Luthfi , Maharani Chatila 
Published: June 2024

Tingkat kolektibilitas peserta Jaminan Kesehatan Nasional (JKN) yang rendah disebabkan karena rendahnya tingkat kepatuhan dalam membayar iuran. Segmen Peserta Bukan Penerima Upah (PBPU) menunggak iuran paling banyak dibandingkan dengan segmen lain yaitu sebesar Rp5,65 triliun (86,88%). Tinjauan sistematis ini bertujuan untuk meninjau secara sistematis faktor-faktor yang berhubungan dengan kepatuhan peserta PBPU dalam membayar iuran JKN di Indonesia. Metode penelitian adalah systematic literature review yang bersumber dari database PubMed, Google Scholar, dan GARUDA dengan rentang waktu dari tahun 2014-2022. Pencarian dan seleksi artikel dilakukan dengan berpedoman pada protokol PRISMA. Protokol penelitian ini telah terdaftar pada PROSPERO (CRD42022378124). Dari 13 artikel yang dianalisis didapatkan faktor-faktor yang berhubungan dengan kepatuhan peserta PBPU dalam membayar iuran JKN meliputi faktor pendapatan, persepsi, motivasi, pendidikan, pengetahuan, usia, jumlah keluarga, pekerjaan, manfaat program, jarak dan waktu tempuh ke tempat pembayaran. BPJS Kesehatan diharapkan dapat terus berinovasi pada sistem pembayaran dalam program JKN agar memudahkan peserta dalam membayar iuran serta rutin melakukan sosialisasi terkait program JKN secara menyeluruh.
Assessing Job Satisfaction of Community Pharmacists with the Warr-Cook-Wall Instrument in West Java
Authors: Kusumah Wardani Sintaresmi , Yasin Nanang Munif , Trung Vo Quang 
Published: June 2024

Background: Improving the quality of public health cannot be separated from the role of pharmacists who are responsible for providing pharmaceutical services. Pharmacists' long working hours and great responsibility impact how satisfied they feel with their jobs.Objectives: This study aims to determine the level of job satisfaction and identify the variables that affect community pharmacists' job satisfaction in West Java.Methods: A cross-sectional study conducted in mid-December 2022 to mid-February 2023 with research subjects community pharmacists working in pharmacies, primary health centers or clinics in the West Java region. A convenience sampling technique was used for selecting a community pharmacist. This study involved 145 community pharmacists and used a semi-structured questionnaire, Warr-Cook-Wall satisfaction scale and implemented the Likert scale to describe pharmacists’ job satisfaction of community pharmacists in West Java. The analysis used is univariate analysis (descriptive and distribution analysis) and bivariate analysis (multiple regression linear analysis).Results: Most community pharmacists in West Java are more satisfied with the variables in the intrinsic factor (3.0±0.66) than extrinsic factors (3.0±0.70). However, their satisfaction is still low on recognition (2.9±0.7) and income (2.7±0.8). Community pharmacists' job satisfaction is influenced by pharmacy ownership type (p=0.04) and working hour (p=0.05). The regression analysis indicates that working hour had negatively influenced job satisfaction.Conclusion: Community pharmacists feel satisfied with their job, and their satisfaction level is affected by pharmacy working hours.
Family Planning Practices, Knowledge, Decision Making, and Factors Associated with Unplanned Pregnancies among Women Working in A Selected Garment Industry in Urban Bengaluru, India
Authors: Hombaiah Chandana 
Published: June 2024

Background: According to UN population estimates, India has surpassed China as the world’s most populated nation, marking the biggest upheaval in global demography since records have been kept. Providing universal family planning services is an important strategy to reduce maternal morbidity and to control population growth. Even though the country has multiple programs addressing family planning issues, they are missing out on working women. Thus, this study aims to estimate the prevalence of unmet needs of family planning and determinants for improper access to family planning methods among women working in a selected Garment industry in Urban Bengaluru. Methodology: A community based cross-sectional study was conducted in a selected garment factory for a period of two months. Women workers in Reproductive age group (18-49 years) and who gave voluntary consent to participate in the study were taken up. Total sample of 454 women were included. The data was collected using a semi-structured and validated questionnaire. Collected data was entered in Microsoft Excel and was analysed using SPSS version 16. Results: Among 454 participants, 42.3% (n=192) of them had used contraceptive method. Out of 192 women, most of them (72.9%, n=140) had chosen tubectomy as the contraceptive measure. Among 407 women, 14.3% (n=58), 13.3% (n=42), and 20.9% (n=9) of them had not planned for their 1st pregnancy, 2nd pregnancy, and 3rd pregnancy respectively. Conclusion: Less than half of them had used any form of contraceptive method. Among that half, nearly three-fourths had chosen tubectomy.
Evaluation of Dosimetric and Radiobiological Parameters for Different TPS Dose Calculation Algorithms and Plans for Lung Cancer Radiotherapy
Authors: Çağlan Ayça , Dirican Bahar 
Published: June 2024

Lung cancer presents a major public health concern in our country and around the globe. Radiotherapy is one of the main treatment modalities for lung cancer management for several years. This study aims to evaluate differences in the dosimetric and radiobiological parameters and in the dose distributions of Planning Target Volume (PTV) and organs at risk (OAR) in patients with lung tumors using different Treatment Planning System (TPS) algorithms and Volumetric Modulated Arc Therapy (VMAT) technique. This study was accomplished in a group of 19 patients with lung tumors who were treated in our clinic. In the treatment planning of the patients; Elekta-Monaco with Monte Carlo (XVMC), Pencil Beam algorithm; Varian-Eclipse with Anisotropic Analytical Algorithm (AAA), Acuros XB (AXB)algorithms and Tomo-plan Treatment Planning System with Convolution Superposition algorithm of Tomotherapy device were used. In these treatment planning systems, plans were done by 6 MV photon energy using Volumetric Arc Therapy (VMAT) techniques. The prescribed dose to the PTV was 60 Gy in 30 fractions. Statistical analysis was performed using SPSS Statistics v.29.0.2.0 programme. Statistically, significant differences were found in Dmean, Dmax, D2 and D98 values for PTV between the algorithms, while small differences were found in Dmax values of the contralateral lung, total lung and esophagus in critical organs. It is concluded that the difference between algorithms for PTV increases especially as the volume of the target tumor decreases. TPS with C/S algorithm gave closer results with XVMC. Algorithms were found to have an impact on radiobiological parameters.
Nilai Energi dan Kadar Zat Gizi pada Formulasi Omelet Berbasis Ikan Kakap Merah dan Wortel
Authors: Fitrasyah Siti Ika , Mellyni Tutri Aprilia , Putri Linda Ayu Rizka , Rahman Nurdin , Tangkas I Made , Ariani Ariani , Aiman Ummu , Nurulfuadi Nurulfuadi , Nadila Devi 
Published: June 2024

Pemberian Makan Bayi dan Anak merupakan kunci untuk meningkatkan kelangsungan hidup anak dan meningkatkan pertumbuhan dan perkembangan yang sehat. Dua tahun pertama kehidupan seorang anak sangat penting, karena zat gizi yang optimal selama periode ini menurunkan penyakit dan mengurangi risiko kematian, dan mendorong perkembangan yang lebih baik secara keseluruhan. Tujuan penelitian ini adalah untuk menganalisis nilai energi dan kadar zat gizi (karbohidrat, protein, lemak, kalsium, dan β -karoten); daya terima; serving size pada formula omelet berbasis ikan kakap merah dan wortel. Jenis penelitian yang digunakan adalah metode eksperimen dengan melakukan percobaan pengolahan formula bahan makanan dari bahan baku telur, ikan kakap merah dan wortel. Desain penelitian analisis zat gizi adalah penelitian deskriptif berbasis uji laboratorium. Sementara itu, desain penelitian yang digunakan pada analisis daya terima adalah uji hedonik organoleptik. Penelitian dilaksanakan di Laboratorium Kimia Analitik, FMIPA dan Gedung FKM, Universitas Tadulako. Penelitian ini dilaksanakan pada bulan Desember 2021 hingga Januari 2022. Analisis kadar karbohidrat menggunakan metode Anthrone, kadar lemak menggunakan metode Soxhletasi, kadar protein dan betakaroten menggunakan metode UV-Vis, dan kadar kalsium menggunakan metode SSA. Analisis data menggunakan analisis One Way ANOVA dan Kruskal-Wallis. Berdasarkan hasil penelitian, semua formula melebihi ± 10% nilai energi; kadar protein; kadar lemak; dan kadar β-Karoten rujukan. Namun, semua formula berada di bawah ± 10% kadar karbohidrat. Sementara itu, F0 dan F1 di bawah ± 10% kadar kalsium rujukan, dan F2-F4 melebihi ± 10% kadar kalsium rujukan. Formula terpilih untuk penentuan serving size lebih lanjut adalah F3. Serving size untuk omelet berbasis ikan kakap merah dan wortel adalah sebesar 50 g. Sebagai kesimpulan, formulasi omelet dengan penambahan ikan kakap merah dan wortel dapat dijadikan sebagai menu selingan alternatif untuk pencegahan kekurangan gizi pada bayi 6-11 bulan.
Hubungan Obesitas dengan Kejadian Hipertensi dan Hiperglikemia di Indonesia
Authors: Badriyah Lulu'ul , Pratiwi Retno Inten Rizqi 
Published: June 2024

Berat badan berlebih akan memicu meningkatkan kadar hormon leptin dalam tubuh. Leptin berperan dalam resistensi insulin dengan mengganggu penyerapan glukosa sehingga meningkatkan kadar gula darah. Selain itu, berat badan berlebih juga memicu peningkatan aktivitas saraf simpatis, resistensi insulin, dan peningkatan aktivitas sistem renin-angiotensin di ginjal yang berkontribusi terhadap hipertensi. Tujuan penelitian ini adalah untuk mengetahui hubungan obesitas dengan kejadian hipertensi dan hiperglikemia di Indonesia. Penelitian ini menggunakan survei nasional Riskesdas 2018 yang memiliki desain studi cross-sectional. Pengambilan sampel Riskesdas tahun 2018 yang dilakukan pada bulan Maret 2018. Sasaran sampelnya adalah 300.000 rumah tangga di 30.000 blok sensus (BS) Susenas dengan metode PPS (probability proportional to size) menggunakan linear systematic sampling dengan two stage sampling. Populasi dalam penelitian adalah seluruh individu berusia 25-45 tahun di Indonesia. Jumlah sampel awal penelitian adalah 305.457 responden dan setelah dilakukan cleaning data, sampel yang memiliki kelengkapan data ada 9.954 responden. Selanjutnya, data dianalisis secara univariat dan bivariat. Analisis bivariat dilakukan menggunakan uji chi-square. Hasil penelitian menunjukkan 44,9% responden mengalami obesitas, 34,0% menderita hipertensi, dan 4,6% mengalami hiperglikemia. Terdapat hubungan yang bermakna antara obesitas dengan kejadian hipertensi (p=0,001) Responden yang kelebihan berat badan memiliki kemungkinan 2,73 kali lebih besar untuk menderita hipertensi dibandingkan responden dengan gizi normal (OR 2,73 2,51–2,97). Terdapat hubungan yang bermakna antara obesitas dengan hiperglikemia (p=0,001). Responden yang mengalami obesitas memiliki kemungkinan 1,89 kali lebih besar untuk mengalami hiperglikemia dibandingkan responden dengan gizi normal (OR 1,89 1,57-2,30). Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat hubungan obesitas dengan kejadian hipertensi dan hiperglikemia.