bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract P3-06-15: Breast cancer molecular profile according to BMI and menopausal status
Authors: Arpino G , Crispo A , De Angelis C , Thomas R , De Laurentiis M , Forestieri V , Colao A , De Placido S 
Published: August 2014

Abstract
Introduction:
High body mass index (BMI) is considered a risk factor for breast cancer onset and is correlated with bad prognosis in breast cancer patients. However, very few studies have associated clinical and molecular tumor characteristics with the patients’ BMI at the time of breast cancer diagnosis. The present study analyses how BMI influences tumor biology and correlates with different molecular subtypes according to menopausal status in a large cohort of patients with new diagnoses of early breast cancer (EBC).
Methods:
Overall 967 patients with a new diagnosis of EBC from 2007 till 2012 were recruited for this study. Clinical and tumor characteristics such as age, menopausal status, weight, height, tumor size (T), grading, estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER2) status, were prospectively collected. BMI was categorized into two groups (low: ≤25; high: &gt;25). Associations between BMI and clinicopathological variables were performed by χ2 test.
Results:
A total of 594 (61%) post-menopause and 373 (39%) pre-menopause women were enrolled. Regardless of menopausal status, patients with high BMI were older (p&lt;0.0001) and had larger tumors (p&lt;0.0001). However, among postmenopausal patients, high BMI correlates with increased ER expression (p = 0.015), lower HER2 expression (p = 0.05) and less aggressive tumor subtypes as luminal A (p = 0.043). In the same patient subset, women with low BMI were more likely to develop a Luminal B, HER2 like or TN breast cancer. No correlation was observed between tumor molecular phenotypes and BMI among premenopausal women.
Conclusion:
Among postmenopausal patient, high BMI is associated with less aggressive and more endocrine sensitive EBC. This is consistent with the hypotheses that higher estrogen exposure of breast tissue in women with higher BMI may drive growth of these cancers. If further confirmed, our data suggests that weight control in this subset of women may help to prevent cancer development.
Table 1Clinical and Molecular CharacteristicsBMI ≤25BMI&gt;25 N%N%totalp valueER .015Positive15376.132884.3481 Negative4823.96115.7109 PgR .2Positive14471.629676.1440 Negative5728.49323.9150 HER2 .05Positive3819.55013.388 Negative15780.532786.7484 MOLECULAR SUBTYPES .043Luminal A11560.225771.2372 Luminal B3015.74813.378 HER2147.3143.928 TN3216.84211.674
Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P3-06-15.
Abstract P3-07-13: Evaluation of epidemiological and molecular differences in African American and Caucasian women with triple negative breast cancer
Authors: Ellsworth RE , Sturtz LA , Melley J , Means M , Shriver CD 
Published: August 2014

Abstract
Background: Breast cancer's (BC) higher mortality rates in African American women (AAW) have been attributed to the higher frequency of triple negative breast cancer (TNBC), an aggressive tumor subtype, in young AAW. What is not known is whether TNBC represents a single disease entity or differs in etiology, molecular characteristics or outcomes by population.
Methods: Demographic, pathological and survival data from AAW (n = 62) and CW (n = 98) with TNBC were analyzed using chi-square analysis, Student's t-tests, and log-rank tests. RNA from laser microdissected TNBC from a subset of patients was hybridized to HG U133A 2.0 microarrays and data analyzed with a FDR &lt;0.05, &gt;2-fold change to define significance.
Results: The frequency of TNBC compared to all BC was significantly higher in AAW (26%) compared to CW (8%), however, significant survival and pathological differences were not detected. The expression of CRYBB2 was ∼4-fold higher in tumors from AAW; these expression levels were able to classify just 64% of AAW patients correctly. Among demographic characteristics, AAW consumed significantly lower amounts of caffeine and alcohol, were less likely to breastfeed and more likely to be obese.
Conclusions: These data suggest that TNBC in AAW is not a unique disease compared to TNBC in CW. Rather, higher frequency of TNBC in AAW may, in part, be attributable to the effects of lifestyle choices. Because these risk factors are modifiable, they provide new opportunities for the development of risk reduction strategies that may effectively decrease survival disparities by preventing the development of TNBC in AAW.
Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P3-07-13.
Abstract P3-08-08: Pattern of use of an online primary health care information resource for breast cancer survivorship education: The pink ribbon survivors network
Authors: Fisher RE , Jensen L , Adams KA 
Published: August 2014

Abstract
Introduction: The Pink Ribbon Survivors Network, a 501(c)(3) nonprofit organization founded by cancer professionals, developed an online educational resource for breast cancer survivors, cancer care professionals, and primary health care providers. The organization created a separate online educational library for each of these three separate audiences. The organization's website launched in July, 2012.
Methods: The Primary Health Care Library for breast cancer survivorship education houses 15 unique categories. Utilizing the organization's administrative website, numerical pattern of access of each separate listing in the 15 categories can be obtained. In addition, Google Analytics data was utilized to determine total website activity for all three educational libraries.
Results: As of abstract submission, the Primary Healthcare Breast Cancer Survivorship Education Library contains 141 clinical articles in 15 categories. The website has been utilized in all 50 of the United States, and in 66 countries and 890 cities. The five most viewed categories of the 15 total categories are (in descending order): 1.) Lifestyle Modifications, 2.) Creating a Link between Cancer Care and Primary Care: Clinical Literature on Survivorship, 3.) Depression/Mood Disturbance, 4.) Consensus Panel Guidelines for Breast Cancer Follow up, and 5.) Gynecologic Issues: Sexuality/Fertility.
Conclusion: Since it's creation in mid- 2012, an online breast cancer survivorship resource is being utilized for educational review. Users of the website are preferentially interested in QOL, healthcare system, and Consensus guidance in their educational viewing. This system can be utilized to disseminate nationally recognized clinical advice for Primary Healthcare Providers as they care for breast cancer survivors in their routine healthcare practices.
Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P3-08-08.
Abstract P3-09-12: Effects of acupuncture on rehabilitation after breast cancer surgery - Preliminary results
Authors: Nazario AP , Giron PS , Simão CA , Facina G 
Published: August 2014

Abstract
Background: The increased incidence of breast cancer and successful treatment result in greater survival of these patients and consequently a greater number of survivors. These patients may have chronic condition of pain in the shoulder and upper limb, including cervical and thoracic spine. This paper seeks, through acupuncture, a new approach in the rehabilitation of these patients.
Method: This study was conducted in the Gynecological Department of São Paulo Federal University. The study included women who underwent surgical treatment of breast cancer, radical or conservative, and present pain in the region of the shoulder and upper limb, including cervical and thoracic spine after three months of surgery. Patients older than 18 years and pain level ≥ 3 on the Visual Analog Scale (VAS). We excluded patients with bilateral breast surgery, metastatic disease, vascular disorders and tactile sensitivity, with diabetes mellitus type I and II uncompensated and education level less than four years.
The patients were randomly divided into two groups, with 15 patients per group who were treated weekly for 10 weeks, one group treated with kinesiotherapy standard, pre-defined, based on stretching the neck muscles, scapular exercises and upper limb strength lasting 30 minutes and the other group was performed the same protocol described above kinesiotherapy followed by another 30 minutes of Acupuncture using pre-defined points.
Acupuncture points used were as follows: CV 3, SP 9, ST 36, KD 7, LV 3 - edema and treat gynecological disorders; VB 21, LI 15, TH 14, LU 5, LI 4, ST 38 and UB 60 - treat pain and difficulty of movement in the upper limb.
Patients were evaluated at baseline, after five weeks and at the end of 10 weeks. We used the Visual Analog Scale (VAS) for pain intensity ratings and the DASH questionnaire (Disabilities of the Arm, Shoulder and Hand Questionnaire) assessing functional capacity in diseases of the upper limb, measuring the skills to do certain activities as well as the symptoms.
Results: The ANOVA test was used for statistical analysis of pain relief by VAS scale in both groups. Both groups had significant improvement with p&gt; 0.001 and no difference between groups, with p = 0.756. The same analysis of variance was used in the DASH questionnaire, with similar results, both groups improved significantly with p&gt; 0.001 and no difference between groups with p = 0.200. In multiple comparisons all reviews are different from each other showing a gradual improvement.
Conclusion: We found that both types of treatment (kinesiotherapy or kinesiotherapy and acupuncture) are effective, and the evolution of the two groups was the same with a gradual improvement.
Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P3-09-12.
Abstract P3-10-04: Prevalence of pain and barriers to pain management in breast cancer survivors in Vietnam
Authors: Nguyen J , Tran TT , Ta TV , Ginsburg O 
Published: August 2014

Abstract
Introduction: Breast cancer-related pain significantly affects quality of life and is well-documented in developed countries. However, little is known about the extent of breast cancer-related pain in developing countries. A study at the National Cancer Institute of Vietnam reported that 44% of breast cancer patients experienced moderate to severe pain. However, this study did not include breast cancer survivors, and little is known about the prevalence of pain and its management in this patient population.
Objectives: Determine the prevalence of pain, adequacy of pain management, and barriers to care in breast cancer survivors in Vietnam.
Methods: We administered previously validated and published symptom assessment tools (the BPI and MDASI) to 160 unselected Vietnamese women diagnosed and treated for breast cancer in 2007. Here we present a preliminary description of the results for the first 40 breast cancer survivors enrolled in this study.
Results: The most frequently reported symptoms were pain (62.5%, with 40% reporting the pain as severe), memory loss (50%), numbness/tingling (50%), sleep disturbance (45%), and appetite loss (32.5%). Only 23% reported adequate symptom management, with the costs of treatment and the false belief that no treatments existed for the pain being frequently cited as barriers to care.
Discussion: Cancer-related pain is highly prevalent in breast cancer survivors treated at the largest cancer hospital in Vietnam. The majority of patients report inadequate management of pain, often attributable to costs and false beliefs regarding pain management. Initiatives aimed at patient education and improving accessibility to pain management could significantly improve the quality of life in this patient population.
Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P3-10-04.
Abstract P3-14-17: Results of a novel neoadjuvant chemotherapy (NAC) for breast cancer
Authors: Rivera-Rodriguez N , Cabanillas F , Lawrenson L , Negron V , Pavia O , Bruno M , Echenique M , Pardo W , Santiago K 
Published: August 2014

Abstract
Background: Achieving a pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) has been associated with improved disease free survival (DFS) and overall survival (OS). The Residual Cancer Burden Score (RCB) method is a useful tool that predicts DFS and OS after NAC. We present the results of pts with either triple negative or HER2 positive breast cancer treated with a novel NAC. Methods: 34 pts with localized breast cancer &gt;1 cm with HER2+ (N = 19) or triple negative breast cancer (TNBC) (N = 15) were treated with this novel regimen consisting first of TEC (docetaxel 75 mg/m2, epirubicin 80 mg/m2, and cyclophosphamide 500 mg/m2) + PEG Filgrastim x 4 cycles. Following the 4th course, TNBC patients received 4 additional TEC cycles if they achieved CR by MRI, or were switched to a non cross-resistant regimen (vinorelbine, bevacizumab, capecitabine) if they had &lt; CR. HER2+ pts received TEC x4 followed by docetaxel + trastuzumab x 4. RCB score was used to measure pathologic response. Pretreament PET scan was done and repeated after course 1 in order to correlate with RCB. Results: Median age was 56 (58 for Her2+ and 49 for TNBC). RCB = 0 (pCR) was achieved in 76%, while only 1 responded poorly (RCB = 3). There was no significant difference in the pCR rate between Her2+ and TNBC patients (74% vs 80% respectively), but there was a difference in the rate of pCR without DCIS and invasive cancer between these two (see table, p = 0.034). Pts with SUV drop &gt; 5% after 1st TEC had 84% pCR while none with &lt; 5% achieved pCR (p = 0.001). Comparison of our results with other NAC regimens reported in the literature is summarized in the table below:
ProtocolpCR (no invasive)pCR(no invasive and no DCIS)RCB 0-1Auxilio Cancer Center HER2+/TNBC74%/80%37%/73%79%/80%I-Spy trial 1 HER2+/TNBC45%/35%N/A61%/40%GeparQuinto HER2+/TNBCN/A45%/38.4%N/ANSABP B-40 TNBC51%N/AN/ANeoAltto HER2+47%N/AN/ANeoSphere HER2+39%N/AN/AMDACC FEC+trastuzumab HER2+60%N/AN/A
Conclusions: This novel chemotherapy approach results in a high pCR rate and RCB 0-1, which have been associated with improved clinical outcomes. Early PET can predict pCR. Although sample size is modest, results are encouraging and deserve further evaluation.
Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P3-14-17.
Abstract P4-01-03: HDACi (vorinostat) in metastatic breast cancer to restore sensitivity to ER-directed (AI) therapy: A phase II clinical trial with FES imaging correlates
Authors: Linden HM , Kurland BF , Link JM , Novakova A , Chai X , Specht JM , Gadi VK , Gralow JR , Schubert EK , Peterson LM , Eary J , Shields A , Mankoff DA , Krohn KA 
Published: August 2014

Abstract
Background: Histone deacetylase inhibitors (HDACi) have shown pre-clinical promise in estrogen receptor(ER)-modulation and restoring sensitivity to endocrine manipulation, suggesting potential clinical benefit (Sabnis 2011) (Huang 2000) in ER+ breast cancer. Vorinostat is an FDA-approved HDACi for CTCL, and could have a beneficial role in restoring ER-signaling in endocrine-resistant tumors (Munster 2011) (Yardley 2011). [F-18]fluoroestradiol (FES) PET imaging may be used to monitor regional tumor ER expression in patients with breast cancer (Linden 2011).
Methods: Patients with metastatic breast cancer with prior clinical benefit from endocrine manipulation who progressed on an AI therapy are eligible for this ongoing trial. In part A, patients were given vorinostat for 2 weeks, then resumed AI for 6 W. In part B (reflecting results of prior HDACi trials) patients are given vorinostat 400mg po daily 5/7 days 3/4 weeks while AI is given continuously. Paired FES and FDG PET are performed at baseline, week 2 and 8; clinical/radiologic assessment of disease is also performed at week 8. Patients with clinical benefit (response or stable disease) may continue on treatment until progressive disease or study withdrawal. Lesion-level analysis of the association between baseline FES uptake (logged) and FES/FDG ratio used generalized estimating equations (GEE) with small-sample adjustments to standard errors.
Results: 12/ 20 planned patients have accrued, and the treatment is well tolerated. Enrolled women were postmenopausal, the majority with primary infiltrating ductal tumors, bone/soft tissue dominant with longstanding metastatic disease, exposed to multiple endocrine and chemotherapy regimens. Five patients have had clinical benefit (2/4 on part B with greater HDACi exposure). One patient withdrew from the study due to toxicity. FES and FDG uptake was analyzed in 42 lesions in 11 patients. Average FES uptake was 2.0 (SULmean) for patients with clinical benefit, and 1.2 in patients with progressive disease by 8 weeks (p = 0.09). FES/FDG ratio at baseline was also associated with response (p = 0.04).
Conclusions: HDACi therapy is promising in relapsed ER+ breast cancer. Imaging of metabolic pathways in parallel with clinical trials may accelerate understanding of the underlying tumor biology and refine treatment selection.
Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-01-03.
Abstract P4-01-04: Role of FDG-PET/CT in evaluating surgical outcomes of operable breast cancer: Usefulness for malignant grade of triple-negative breast cancer
Authors: Ohara M , Hideo S , Akiko E , Masumoto N , Ozaki S , Kadoya T , Okada M 
Published: August 2014

Abstract
Background: The aim of this study was to evaluate the significance of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for speculating the malignant level and prognostic value of operable breast cancers.
Methods: Of 578 consecutive patients with primary invasive breast cancer who underwent curative surgery between 2005 and 2010, 311 patients (53.8%) who received FDG PET/CT before initial therapy were examined.
Results: Receiver operating characteristics (ROC) curve analysis showed the cutoff value of the maximum standardized uptake value (SUVmax) to predict cancer recurrence was 3.8 in all patients and 8.6 in patients with the triple-negative subtype, respectively. In all patients, 3-year DFS rates were 98.8% for patients with a tumor of SUVmax ≤ 3.8 and 91.6% for patients with a tumor of SUVmax &gt; 3.8 (p &lt; 0.001). High value of SUVmax was significantly associated with large tumor size (p &lt; 0.001), lymph node metastasis (p = 0.040), high nuclear grade (p &lt; 0.001), lymphovascular invasion (p = 0.032), negative hormone receptor status (p &lt; 0.001), and positive HER2 status (p = 0.014). Based on the results of multivariate Cox analysis in all patients, high SUVmax (p = 0.001) and negative hormone receptor status (p = 0.005) were significantly associated with poor prognosis. In patients with triple-negative subtype, 3-year DFS rates were 90.9% for patients with a tumor of SUVmax ≤ 8.6 and 42.9% for patients with a tumor of SUVmax &gt; 8.6 (p = 0.002), and high SUVmax was the only significant independent prognostic factor (p = 0.047).
Conclusion: FDG-PET/CT is useful for predicting malignant behavior and prognosis in patients with operable breast cancer, especially the triple-negative subtype.
Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-01-04.
Abstract P4-01-13: Fusion imaging using opto-acoustics and ultrasound to differentiate breast mass histopathology
Authors: Lavin P , Stavros AT , Tucker FL 
Published: August 2014

Abstract
Introduction: Opto-acoustics (OA) is a true fusion imaging technology that combines dual energy laser optic functional imaging with real time gray scale ultrasound morphologic imaging. The laser optic component uses two wavelengths that have been chosen to optimally demonstrate oxygenated and deoxygenated hemoglobin. The color-coded laser optic images are co-registered and temporally interleaved with real time gray scale images. OA fusion imaging benefits from the combination of the high contrast resolution of dual wavelength laser optics and the higher spatial resolution and penetration of gray scale ultrasound. OA can demonstrate both tumor neovascularity and the relative degrees of oxygenation-deoxygenation within breast mass and within the surrounding tissues.
Methodology: A series of 68 prospective patients with undiagnosed breast masses going to biopsy were evaluated before biopsy with a handheld device combining ultrasound co-registered with OA for the visualization of pre-defined internal and external features. The internal features included vascularity (V), blush (BU), and blood (BL) accumulation while external features included boundary zone vascularity and blush (BZ) and peri-tumoral radiating vessels (RV); each were scored on a 0-5 ordinal scale and were summed to get a total internal score, total external score, and a total score. A two-sided exact Jonckheere-Terpstra test was used to test the relationship between increasing scores and higher cancer grade.
Results: The study population consisted of 29 fibroadenomas (FAs) as well as 10 invasive ductal carcinoma (IDC), grade 1, 11 IDC grade 2, and 18 IDC grade 3 cases. OA Total (two-sided p = 3×10−8) and OA Total Internal (two-sided p = 6×10−9) were highly significant but OA Total External was not statistically significant; OA Total and OA Total Internal Features were highly related to histology with lower scores for FAs increasing progressively to highest scores for IDC 3. Moreover, all three internal OA features were highly significant: (1) V (two-sided p = 10−7), BU (two-sided p = 3×10−8), and BL (two-sided p = 5×10−6).
Cumulative contribution of each internal feature to the total internal score was also assessed for each histopathology subgroup to confirm independent contribution to the OA Total Internal Score. Pairwise correlations explained no more than 56% of the total variance.
Conclusions: We have established the prognostic value of OA Total and OA Internal Features as well as the validation of the contributions of each OA Internal Feature. Using the combination of individual internal and external OA features not only helps distinguish benign from malignant masses, but helps stratify malignant lesions by histologic grade. These abilities could be useful both for diagnosis and for monitoring non-surgical treatment of malignant masses.
Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P4-01-13.