bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trajectory-tracking controller design with constraints in the control signals: a case study in mobile robots
Authors: Serrano Mario Emanuel , Scaglia Gustavo Juan Eduardo , Cheein Fernando Auat , Mut Vicente , Ortiz Oscar Alberto 
Published: May 2014

SUMMARYThis paper is a continuation of a previous work of authors, Scagliaet al. [G. J. E. Scaglia, L. M. Quintero, V. Mut and F. Di Sciascio, “Numerical methods based controller design for mobile robots,”Robotica27(2), 269–279 (2009)]. A method is presented to choose the controller parameters such that, the values of the control actions do not exceed the maximum allowable and the tracking errors tend to zero. In addition, the analysis of the controller design parameters is included. The experimental results (laboratory experiments and a real world application) demonstrate the efficiency of the controller.
IGF-I slightly improves nuclear maturation and cleavage rate of bovine oocytes exposed to acute heat shockin vitro
Authors: Meiyu Qi , Liu Di , Roth Zvi 
Published: May 2014

SummaryAnin vitromodel of embryo production was used to examine the effects of insulin-like growth factor (IGF)-I on maturation and developmental competence of oocytes exposed to heat shock. Cumulus–oocyte complexes were matured at 38.5°C or exposed to acute heat shock (HS; 41.5°C), with or without 100 ng/ml IGF-I, for 22 h throughin vitromaturation. The experimental groups were control (C), C + IGF-I, HS, and HS + IGF-I. Oocytes were fertilized at the end of maturation, and the proportion of cleaved embryos was recorded 44 h later. HS during maturation increased the proportion of TUNEL-positive oocytes (P< 0.05). HS did not have any effect on cortical granule translocation but impaired resumption of meiosis, expressed as a decreased proportion of oocytes with nuclei in metaphase I (P <0.05) and metaphase II (MII;P <0.05). HS decreased the proportion of oocytes that cleaved (P< 0.05), in particular those oocytes that further developed to 4-cell-stage embryos (P< 0.05). IGF-I alleviated, to some extent, the deleterious effects of HS on the oocytes as reflected by a reduced proportion of TUNEL-positive oocytes (P< 0.03). While not significant, IGF-I tended to increase the proportion of MII-stage oocytes (P< 0.08) and 4-cell-stage cleaved embryos (P< 0.06). Further examination is required to explore whether IGF-I also affects the developmental competence of oocytes exposed to HS.
Effects of maternal ageing on ICSI outcomes and embryo development in relation to oocytes morphological characteristics of birefringent structures
Authors: Korkmaz Cem , Tekin Yesim Bayoglu , Sakinci Mehmet , Ercan Cihangir Mutlu 
Published: May 2014

SummaryThe aim of this study was to determine the morphological characteristics of the older reproductive aged women's oocytes and to reveal the influence of these characteristics on intra-cytoplasmic sperm injection (ICSI) outcomes. The oocytes of women older than 35 years of age were evaluated retrospectively. Non-invasive polarization microscopy (PolScope) examinations of mature oocytes were performed by measurement of meiotic spindles’ length, area and retardance and zona pellucida thickness and retardance. Fertilization and conception competence and the correlation with the birefringent structures were assessed. Two hundred and thirteen mature oocytes from 54 women were evaluated with a PolScope. Length of the meiotic spindle was shown to be related to fertilization success of women with advanced maternal age. In conclusion, the PolScope is a useful device used to identify the oocyte quality. Quantitative measurements of meiotic spindle parameters may be valuable for the selection of high-quality oocytes that have the potential for embryo development in the in vitro fertilization (IVF) laboratory of women older than 35 years of age who are mostly poor responders.
Kant on Existential Import
Authors: Vanzo Alberto 
Published: May 2014

AbstractThis article reconstructs Kant's view on the existential import of categorical sentences. Kant is widely taken to have held that affirmative sentences (theAandIsentences of the traditional square of opposition) have existential import, whereas negative sentences (EandO) lack existential import. The article challenges this standard interpretation. It is argued that Kant ascribes existential import only to some affirmative synthetic sentences. However, the reasons for this do not fall within the remit of Kant's formal logic. Unlike traditional logic and modern standard quantification theory, Kant's formal logic is free from existential commitments.
Patriotism, Poverty, and Global Justice: A Kantian Engagement with Pauline Kleingeld's Kant and Cosmopolitanism
Authors: Varden Helga 
Published: May 2014

AbstractIn this article I critically engage some of the philosophical ideas Kleingeld presents in Kant and Cosmopolitanism, namely patriotism, poverty and global justice. Against Kleingeld, I propose, first, that perhaps democracy is less important and affectionate love more so to both Kant himself as well as to an account that can successfully refute a Bernard Williams style ‘one-thought-too-many’ objection to Kantian patriotism; second, that guaranteeing unconditional poverty relief for all its citizens is constitutive of the minimally just state for Kant; and, third, that there seem to be more disanalogies between the domestic and the global public authorities in Kant's account of right than Kleingeld's interpretation allows for.
Maternal perceptions of supervision in pre-school-aged children: a qualitative approach to understanding differences between families living in affluent and disadvantaged areas
Authors: Ablewhite Joanne , Kendrick Denise , Watson Michael , Shaw Ian 
Published: May 2014

AimTo explore maternal perceptions of supervision and childhood unintentional injury in order to develop understanding and explanation for differences in unintentional injury rates between an advantaged and disadvantaged area.BackgroundUnintentional injury is the second cause of mortality and a significant cause of morbidity in the zero to four year age group. Children living in socio-economic disadvantage are at a greater risk of unintentional injury than their more affluent counter-parts.MethodsQualitative study using semi-structured interviews; content data analysis was undertaken. Participants included 37 mothers with a child aged less than five years; 16 living in an area of disadvantage (and high rate of childhood unintentional injury) and 21 living in an advantaged area (and low rate of childhood unintentional injury).FindingsParents in both areas described the importance of parental supervision in reducing child unintentional injury risks. Parents in both areas used listening as a supervision strategy. Parents in both areas described how ‘when the child goes quiet’ that is a cue for them to make a visual check on the child. Listening was used more for boys than girls in both areas, but parents in the advantaged area used listening as a supervision strategy more frequently than those in the disadvantaged area. Parents described supervision strategies as being shaped by child character and age rather than child gender. Parents in both areas described similar strategies for managing distractions. An important difference was found with regard to older siblings; parents living in the advantaged area described older siblings as an injury risk to younger children. Parents in the disadvantaged area described older siblings as providing some supervision for younger children. Parents living in disadvantaged circumstances may face greater challenges with regard to supervision than parents living in advantaged circumstances and this may partly explain differences in injury risk.
Separating NADH and NADPH fluorescence in live cells and tissues using FLIM
Authors: Blacker Thomas S. , Mann Zoe F. , Gale Jonathan E. , Ziegler Mathias , Bain Angus J. , Szabadkai Gyorgy , Duchen Michael R. 
Published: May 2014

AbstractNAD is a key determinant of cellular energy metabolism. In contrast, its phosphorylated form, NADP, plays a central role in biosynthetic pathways and antioxidant defence. The reduced forms of both pyridine nucleotides are fluorescent in living cells but they cannot be distinguished, as they are spectrally identical. Here, using genetic and pharmacological approaches to perturb NAD(P)H metabolism, we find that fluorescence lifetime imaging (FLIM) differentiates quantitatively between the two cofactors. Systematic manipulations to change the balance between oxidative and glycolytic metabolism suggest that these states do not directly impact NAD(P)H fluorescence decay rates. The lifetime changes observed in cancers thus likely reflect shifts in the NADPH/NADH balance. Using a mathematical model, we use these experimental data to quantify the relative levels of NADH and NADPH in different cell types of a complex tissue, the mammalian cochlea. This reveals NADPH-enriched populations of cells, raising questions about their distinct metabolic roles.
Asymmetrically interacting spreading dynamics on complex layered networks
Authors: Wang Wei , Tang Ming , Yang Hui , Younghae Do  , Lai Ying-Cheng , Lee GyuWon 
Published: May 2014

AbstractThe spread of disease through a physical-contact network and the spread of information about the disease on a communication network are two intimately related dynamical processes. We investigate the asymmetrical interplay between the two types of spreading dynamics, each occurring on its own layer, by focusing on the two fundamental quantities underlying any spreading process: epidemic threshold and the final infection ratio. We find that an epidemic outbreak on the contact layer can induce an outbreak on the communication layer and information spreading can effectively raise the epidemic threshold. When structural correlation exists between the two layers, the information threshold remains unchanged but the epidemic threshold can be enhanced, making the contact layer more resilient to epidemic outbreak. We develop a physical theory to understand the intricate interplay between the two types of spreading dynamics.
Window of audio-visual simultaneity is unaffected by spatio-temporal visual clutter
Authors: Van der Burg Erik , Cass John , Alais David 
Published: May 2014

AbstractIn the present study we investigate the rules governing the perception of audiovisual synchrony within spatio-temporally cluttered visual environments. Participants viewed a ring of 19 discs modulating in luminance while hearing an amplitude modulating tone. Each disc modulated with a unique temporal phase (40 ms intervals), with only one synchronized to the tone. Participants searched for the synchronised disc whose spatial location varied randomly across trials. Square-wave modulation facilitated search: the synchronized disc was frequently chosen, with tight response distributions centred near zero-phase lag. In the sinusoidal condition responses were equally distributed over the 19 discs regardless of phase. To investigate whether subjective synchrony in the square-wave condition was limited by spatial or temporal factors we repeated the experiment with either reduced spatial density (9 discs) or temporal density (80 ms phase intervals). Reduced temporal density greatly facilitated synchrony perception but left the synchrony bandwidth unchanged, while no influence of spatial density was found. We conclude that audio-visual synchrony is not strongly constrained by the spatial or temporal density of the visual display, but by a temporal window within which audio-visual events are perceived as synchronous, with a full bandwidth of ~185 ms.
Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity
Authors: Funk Kristen E. , Thomas Stefani N. , Schafer Kelsey N. , Cooper Grace L. , Liao Zhongping , Clark David J. , Yang Austin J. , Kuret Jeff 
Published: May 2014

In Alzheimer's disease, the microtubule-associated protein tau dissociates from the neuronal cytoskeleton and aggregates to form cytoplasmic inclusions. Although hyperphosphorylation of tau serine and threonine residues is an established trigger of tau misfunction and aggregation, tau modifications extend to lysine residues as well, raising the possibility that different modification signatures depress or promote aggregation propensity depending on site occupancy. To identify lysine residue modifications associated with normal tau function, soluble tau proteins isolated from four cognitively normal human brains were characterized by MS methods. The major detectable lysine modification was found to be methylation, which appeared in the form of mono- and di-methyl lysine residues distributed among at least 11 sites. Unlike tau phosphorylation sites, the frequency of lysine methylation was highest in the microtubule-binding repeat region that mediates both microtubule binding and homotypic interactions. When purified recombinant human tau was modified in vitro through reductive methylation, its ability to promote tubulin polymerization was retained, whereas its aggregation propensity was greatly attenuated at both nucleation and extension steps. These data establish lysine methylation as part of the normal tau post-translational modification signature in human brain, and suggest that it can function in part to protect against pathological tau aggregation.
Development of compact directional antenna utilising plane of symmetry for wideband brain stroke detection systems
Authors: Mobashsher A.T. , Abbosh A. 
Published: May 2014

Microwave‐based brain stroke detection demands low profile, compact, directive and wideband antennas for efficient imaging using portable systems. Using image theory of electromagnetics, the magnetic symmetry plane of a folded antenna is utilised for its miniaturisation to half of its original volume without sacrificing its penetration capability or radiation directivity. The antenna achieves 63% fractional bandwidth (1.25–2.4 GHz) with 3.5 dBi average gain along the direction of radiation. Both the near‐field and far‐field radiations are characterised to ensure the antenna's applicability in the detection system. Moreover, the radiation safety is also analysed since the antenna has to operate in close proximity to the head. The overall dimensions of the proposed antenna are 0.29λ0 × 0.12λ0 × 0.06λ0 (λ0 = lowest operating wavelength).
Tunable 245 GHz transmitter and receiver in SiGe technology for gas spectroscopy
Authors: Schmalz K. , Mao Y. , Borngräber J. , Neumaier P. , Hübers H.‐W. 
Published: May 2014

A 245 GHz sensor system for gas spectroscopy is presented, which includes an integrated SiGe transmitter (TX) and receiver (RX), and a 0.6 m‐long gas absorption cell between the TX and RX modules. The integrated local oscillators (LOs) of TX and RX chips are controlled by two external phase‐locked loops (PLLs), whose reference frequencies are swept with constant frequency offset for a low intermediate frequency of the RX. The RX consists of a differential low‐noise amplifier, an integrated 122 GHz LO with a 1/64 divider, a 90° differential hybrid and an active subharmonic mixer. The TX consists of an integrated 122 GHz LO with a 1/64 divider, and a frequency doubler. The TX and RX chips are fabricated in 0.13 µm SiGe BiCMOS technology with fT/fmax of 300 GHz/500 GHz. Using external dielectric lenses for the TX and RX modules, the gas absorption spectra were measured for acetonitrile and methanol.
Miniature wideband bandpass filter based on electric and magnetic coupling paths
Authors: Asadbeigi H. , Virdee B.S. 
Published: May 2014

A compact wideband bandpass filter design that provides a sharp roll‐off and low loss performance is presented. The design is based on employing two separate paths between the adjacent resonators constituting the filter, where one path enables electric coupling and the other one magnetic coupling. This structure generates zeros in the filter's transmission response due to the dominance of electric coupling. A fourth‐order filter was fabricated and tested. Correlation between the simulated and measured results is remarkable. The measured results confirm the fractional bandwidth of 70% at the centre frequency of 4.58 GHz, insertion‐loss is <0.55 dB with a return‐loss better than 15 dB in the passband. The filter occupies an area of 4.1 × 17.8 mm, which corresponds to 0.1λo × 0.44λo, where λo is the wavelength of the centre frequency.
One‐step hydrothermal synthesis of the Ag/AgI heterojunction with highly enhanced visible‐light photocatalytic performances
Authors: Wang Xinjun , Wan Xiaoli , Li Wuqi , Chen Xuenian 
Published: May 2014

The Ag/AgI heterojunction was prepared by a facile, one‐step and low‐temperature hydrothermal synthesis method with P, I2 and Ag2O. The approach proves a green and simple route to the products, which avoided multiple‐step synthesis and the subsequent time‐consuming photoreduction. The samples were carefully characterised by X‐ray diffraction, X‐ray photoelectronic spectra, scanning electron microscopy, transmission electron micrographs and ultraviolet–visible‐light techniques. The results show that Ag nanoparticles were uniformly distributed on the surface of AgI and the heterostructure was formed. Under visible light, the photocatalytic activity of the Ag/AgI composites for the degradation of rhodamine B (RhB) was efficient and much higher than that of pure AgI. In particular, the Ag/AgI composites (at 120°C for 4 h) exhibited the best photocatalytic activity, and nearly 98% of RhB was degraded within 20 min. Remarkably, the photocatalytic degradation followed the pseudo‐first‐order reaction model and the corresponding apparent first‐order rate constant of 0.157 min−1 which is five times more than that of pure AgI. The enhanced photocatalytic activity of Ag/AgI can be attributed to the strong surface plasmon resonances.
Use of transmission electron microscopy to identify nanocrystals of challenging protein targets
Authors: Stevenson Hilary P. , Makhov Alexander M. , Calero Monica , Edwards Andrea L. , Zeldin Oliver B. , Mathews Irimpan I. , Lin Guowu , Barnes Christopher O. , Santamaria Hugo , Ross Ted M. , Soltis S. Michael , Khosla Chaitan , Nagarajan V. , Conway James F. , Cohen Aina E. , Calero Guillermo 
Published: May 2014

Significance
X-ray crystallography is the primary technique used to obtain high-resolution structures of proteins. This method relies on diffracting large crystals that are identified by bright-field microscopy and usually optimized from an initial smaller and lower quality crystalline hit. Because of the limits of the optical methods used to visualize and identify these crystals, smaller nanometer crystals are excluded from the results of typical evaluations. However, the field of nanocrystallography, which utilizes a free electron laser to solve structures from nanocrystal (NC) slurries, makes these unidentified crystals highly useful. This paper presents a method, relying on transmission electron microscopy, to identify NCs, determine if they are protein, and evaluate their quality.
Functional magnetic resonance microscopy at single-cell resolution in
Aplysia californica
Authors: Radecki Guillaume , Nargeot Romuald , Jelescu Ileana Ozana , Le Bihan Denis , Ciobanu Luisa 
Published: May 2014

Significance
The direct observation with MRI of neuronal activity at single-neuron resolution represents a significant advancement in magnetic resonance (MR) microscopy and functional neuroimaging. The vast majority of high-resolution MR microscopy studies remain restricted to the generation of static images. This study shifts the focus of MR microscopy from noninvasive static imaging to dynamic investigations of activity in single cells and neuronal networks. Although most functional neuroimaging investigations are limited to averaging the signal from clusters of hundreds of neurons, we show that we are able to record the activity coming from individual neurons and their responses to sensory stimuli.
Functional expression of recombinant human macrophage β-glucan receptor dectin-1 using baculovirus–silkworm expression system
Authors: Ujita Minoru , Koike Shota , Yamauchi Yosuke , Kiochi Noburo , Yura Hiroki , Yamanaka Mayumi , Okumura Hiroki 
Published: May 2014

Abstract
Human macrophage dectin-1, a type II transmembrane β-glucan receptor, was expressed as a fusion protein with an N-terminal hexahistidine tag in a baculovirus–silkworm expression system and assayed for binding activity. Recombinant dectin-1 specifically bound to some β-glucans, and the neck domain and N-linked oligosaccharide chains of human dectin-1 did not affect the ligand binding activity and specificity of the receptor.
Cost-Effectiveness of Ensuring Hepatitis B Protection for Previously Vaccinated Healthcare Personnel
Authors: Hoerger Thomas J. , Bradley Christina , Schillie Sarah F. , Reilly Meredith , Murphy Trudy V. 
Published: May 2014

ObjectiveTo examine the cost-effectiveness of pre- and postexposure approaches for ensuring hepatitis B protection among previously vaccinated healthcare personnel (HCP).DesignA decision-analytic model was developed for alternative strategies of ensuring hepatitis B protection under assumptions of 68% and 95% long-term protection after a primary vaccination series. Costs and quality-adjusted life years (QALYs) lost from infections were estimated, and incremental cost-effectiveness ratios (ICERs) were calculated relative to a no intervention alternative over 10 years of intervention. Separate analyses were performed for trainees and nontrainees, using the healthcare system perspective. Trainees face higher risk of exposure and likely received primary vaccination as infants.SettingGeneral healthcare settings.ParticipantsTrainee and nontrainee HCP.InterventionsPreexposure testing for antibody to hepatitis B surface antigen followed by additional vaccination for HCP without protective antibody levels; postexposure evaluation and management for HCP reporting blood or body fluid exposuresResultsThe preexposure strategy prevents more infections and has higher costs than the postexposure strategy or no intervention. For trainees, 10-year preexposure evaluation ICERs are $832,875 and $144,457 per QALY for 95% and 68% long-term vaccine protection, respectively. Trainee 10-year postexposure evaluation ICERs are $1,146,660 and $191,579 per QALY under the 95% and 68% long-term protection assumptions, respectively. For nontrainees, 10-year ICERs are $745,739 and $1,129,286 per QALY for the preexposure and postexposure evaluation strategies, respectively.ConclusionsICERs may inform decision makers as they decide whether the added cost of the preexposure strategy provides sufficient value in preventing infections.
AlphaMPSim: flexible simulation of multi-parent crosses
Authors: Hickey John M. , Gorjanc Gregor , Hearne Sarah , Huang Bevan E. 
Published: May 2014

Abstract
Summary: Multi-parent crosses of recombinant inbred lines exist in many species for fine-scale analysis of genome structure and marker–trait association. These populations encompass a wide range of crossing designs with varying potential. AlphaMPSim is a flexible simulation program that is efficiently designed for comparison of alternative designs for traits with varying genetic architectures and biallelic markers with densities up to full sequence. A large pool of founder haplotypes can be supplied by the user, or generated via integration with external coalescent simulation programs such as MaCS. From these, diverse founders for multi-parent designs can be generated automatically, and users can compare designs generated from diverse pedigrees. Full tracking of identity by descent status of alleles within the pedigree is undertaken, and output files are compatible with commonly available analysis packages in R.
Availability and implementation: Executable versions of AlphaMPSim for Mac and Linux and a user manual are available at http://www.roslin.ed.ac.uk/john-hickey/software-packages/ .
Contact: john.hickey@roslin.ed.ac.uk
Supplementary information: Supplementary data are available at Bioinformatics online.