bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does cutaneous lupus erythematosus have more favorable pregnancy outcomes than systemic disease? A two‐center study
Authors: Hamed Hossam O. , Ahmed Salah R. , Alzolibani Abdallatif , Kamal Manal M. , Mostafa Marwa S. , Gamal Rania M. , Atallah Dalia A.A. , Abd‐El‐Aall Diaa‐Eldeen M. 
Published: April 2013

AbstractObjectiveTo compare pregnancy outcomes in cutaneous lupus erythematosus (CLE) with systemic lupus erythematosus (SLE) and healthy pregnant women.DesignCohort comparative study.SettingTwo university maternity centers in Saudi Arabia and Egypt.PopulationPregnant women with CLE and SLE and healthy pregnant women.MethodsOver a three‐year period, 201 participants were allocated to three groups: group 1 (n = 67) contained women with CLE, group 2 (n = 67) women with SLE, and group 3 healthy controls (n = 67). Diagnosis of lupus erythematosus was based on American College of Rheumatology criteria. All participants were followed until delivery. Lupus exacerbation was evaluated by Lupus Activity Index score. ANOVA and chi‐squared tests were used to compare obstetrical and neonatal outcomes, and regression analysis was used to define independent factors of adverse pregnancy outcomes.Main outcome measuresPregnancy losses, preterm labor, intrauterine growth restriction, preeclampsia, neonatal intensive care unit admissions, cesarean sections and lupus exacerbations.ResultsThere was no significant difference between groups 1 and 3 in rates of pregnancy loss, preterm labor, preeclampsia, intrauterine growth restriction and neonatal intensive care admission. Group 1 had lower pregnancy loss (p = 0.005), growth restriction (p = 0.001), preeclampsia (p = 0.05), neonatal intensive care admissions (p = 0.001), cesarean section (p = 0.03), lupus exacerbations (p = 0.05) and anti‐phospholipid antibodies (p = 0.02) compared with group 2. In groups 1 and 2, lupus exacerbation and anti‐phospholipid antibodies were significant independent factors for adverse outcomes.ConclusionsCutaneous lupus erythematosus means comparable pregnancy outcomes to those of the healthy population. Lower rates of disease exacerbation and anti‐phospholipid antibodies are potential factors for better pregnancy outcome in CLE compared with SLE.
Corneal endothelial cell changes after cataract surgery in patients on systemic sympathetic α‐1aantagonist medication (tamsulosin)
Authors: Storr‐Paulsen Allan , Jørgensen Jesper Skovlund , Norregaard Jens Christian , Thulesen Jesper 
Published: April 2013

Abstract.Purpose: The purpose of this study was to assess the incidence of intraoperative floppy iris syndrome (IFIS) and the morphology of the corneal endothelium after cataract extraction in Caucasian male patients exposed to the α‐1aadrenergic receptor antagonist tamsulosin.Methods: In a clinical prospective study, 23 male patients (23 eyes) treated with tamsulosin due to benign prostatic hyperplasia and 25 male patients (25 eyes) with no tamsulosin treatment had cataract surgery. The divide‐and‐conquer technique was used with the Infinity OZil®machine. A combination of Healon and Healon5 was used in all patients, but the use of additional Vision Blue, iris retractors or intracameral phenylephrine in the tamsulosin group was at the discretion of the surgeon. The endothelial cell density, variation in endothelial cell size (CV), percentage of hexagonal cells and central corneal thickness (CCT) were recorded at baseline and at 3 months postoperatively.Results: In the tamsulosin‐treated group, 19 of 23 eyes (83%) developed IFIS, compared with no IFIS in the control group. Compared with the control group, the tamsulosin group showed significantly less dilatation at the start of the operation, significant miosis during surgery and significantly greater corneal endothelial cell loss 3 months postoperatively (12% versus 3%; p < 0.001).Conclusion: Intraoperative floppy iris syndrome during cataract surgery is significantly associated with tamsulosin‐treated male patients. Patients on tamsulosin showed less preoperative dilatation, significant miosis during surgery, and had significantly greater postoperative endothelial cell loss compared with nontreated patients despite recommended precautions.
Maternal smoking modulates fatty acid profile of breast milk
Authors: Szlagatys‐Sidorkiewicz Agnieszka , Martysiak‐Żurowska Dorota , Krzykowski Grzegorz , Zagierski Maciej , Kamińska Barbara 
Published: April 2013

AbstractAimWe hypothesized that the fatty acid composition of breast milk can be affected by a smoking habit in the mother. Consequently, this study verified whether maternal smoking modulates, and if so to what extent, the breast milk fatty acid profile.MethodsThe study included 20 postpartum women who declared smoking more than five cigarettes daily throughout a period of pregnancy and lactation, and 136 nonsmoking postpartum women. Breast milk samples were collected between the 17th and the 30th day after delivery. The samples were analysed by means of high‐resolution gas chromatography for overall content of saturated, monounsaturated and polyunsaturated fatty acids.ResultsCompared with nonsmokers, smokers were characterized by significantly higher relative breast milk contents of fatty acids and monounsaturated fatty acids. Additionally, smokers’ breast milk had higher concentrations of selected saturated fatty acids, monounsaturated fatty acids and polyunsaturated fatty acids. Furthermore, smokers were characterized by significantly lower values of linoleic to arachidonic acid ratio and n‐6 to n‐3 polyunsaturated fatty acids ratio.ConclusionsAside from its other harmful consequences, smoking modulates the fatty acid profile of human milk.
Effect of hypnotherapy and educational intervention on brain response to visceral stimulus in the irritable bowel syndrome
Authors: Lowén M. B. O. , Mayer E. A. , Sjöberg M. , Tillisch K. , Naliboff B. , Labus J. , Lundberg P. , Ström M. , Engström M. , Walter S. A. 
Published: April 2013

SummaryBackgroundGut‐directed hypnotherapy can reduce IBS symptoms, but the mechanisms underlying this therapeutic effect remain unknown.AimTo determine the effect of hypnotherapy and educational intervention on brain responses to cued rectal distensions in IBS patients.MethodsForty‐four women with moderate‐to‐severe IBS and 20 healthy controls (HCs) were included. Blood oxygen level dependent (BOLD) signals were measured by functional Magnetic Resonance Imaging (fMRI) during expectation and delivery of high‐ (45 mmHg) and low‐intensity (15 mmHg) rectal distensions. Twenty‐five patients were assigned to hypnotherapy (HYP) and 16 to educational intervention (EDU). Thirty‐one patients completed treatments and posttreatment fMRI.ResultsSimilar symptom reduction was achieved in both groups. Clinically successful treatment (all responders) was associated with significant BOLD attenuation during high‐intensity distension in the dorsal and ventral anterior insula (cluster size 142, P = 0.006, and cluster size 101, P = 0.005 respectively). Moreover HYP responders demonstrated a pre–post treatment BOLD attenuation in posterior insula (cluster sizes 59, P = 0.05) while EDU responders had a BOLD attenuation in prefrontal cortex (cluster size 60, P = 0.05). Pre–post differences for expectation conditions were almost exclusively seen in the HYP group. Following treatment, the brain response to distension was similar to that observed in HCs, suggesting that the treatment had a normalising effect on the central processing abnormality of visceral signals in IBS.ConclusionsThe abnormal processing and enhanced perception of visceral stimuli in IBS can be normalised by psychological interventions. Symptom improvement in the treatment groups may be mediated by different brain mechanisms. Clinical trial number: NCT01815164.
Effect of displaced versus non‐displaced pelvic fractures on long‐term racing performance in 31Thoroughbred racehorses
Authors: Hennessy SE , Muurlink MA , Anderson GA , Puksmann TN , Whitton RC 
Published: April 2013

ObjectiveTo evaluate the long‐term racing prognosis forThoroughbred racehorses with displaced versus non‐displaced fractures of the pelvis identified by scintigraphy.DesignRetrospective case analysis.MethodsMedical records of 31Thoroughbred racehorses presenting to theUniversity ofMelbourneEquineCentre with fractures of the pelvis that were identified by scintigraphy were reviewed. Pelvic fracture site was determined and defined as displaced or non‐displaced based on ultrasound and/or radiographic findings. Race records were analysed for each horse, with a minimum of 24 months' follow‐up, and correlated with fracture type to determine long‐term prognosis for racing. Results are expressed as median and range.ResultsFractures at a single site were more common (n = 22) than fractures involving two sites (n = 9) and the ilial wing was the most commonly affected (n = 12).Thoroughbred racehorses with displaced pelvic fractures at any site (n = 12) raced fewer times within 24 months of diagnosis than horses with non‐displaced fractures (n = 19) (median 0.5, range 0–13 vs 7, 0–24;P= 0.037), but there was no clear statistical difference in race earnings between the two groups (median A$0, range A$0–$123,250 vs A$14,440, A$0–$325,500, respectively;P= 0.080). Four horses with displaced fractures (33%) were euthanased on humane grounds because of persistent severe pain. When these horses were excluded from the analysis, there were no differences in performance variables between horses with a displaced or non‐displaced pelvic fracture.ConclusionThoroughbred racehorses with a displaced or non‐displaced pelvic fracture that survive the initial post‐injury period have a good prognosis for racing.
Comparative description of the hairy structures in two endemic Velia species (Insecta: Hemiptera: Heteroptera: Veliidae): V. currens (Fabricius, 1794) and V. gridellii Tamanini, 1947
Authors: Cianferoni Fabio , Santini Giacomo 
Published: April 2013

AbstractThis study provides the first description, based on SEM imagery, of the hairy structures related to life on the water surface of two Alpine‐Apenninic species belonging to the genus Velia: V. currens (Fabricius, 1794) and V. gridellii Tamanini, 1947. In general, no relevant differences in the organization and form of these structures were found between the two species. Similarly, few differences were observed between males and females, and in comparison with the only congeneric with hairy structures thus far described, V. caprai Tamanini, 1947, confirming a substantial homogeneity within the subgenus Plesiovelia. The discovery of a double layer of microtrichia in both our species allowed us to detect them even in V. caprai, for which only a single layer was previously described. Finally, the presence of a structure corresponding to the male grasping comb was discovered in females of V. gridellii and is reported for the first time in the genus and in the Old World Veliinae. A similar structure was not identified in V. currens. This difference may be relevant for better understanding the relationships among species belonging to this genus.
A controlled evaluation of the ‘FRIENDS for Life’ emotional resiliency programme on overall anxiety levels, anxiety subtype levels and school adjustment
Authors: Rodgers Alish , Dunsmuir Sandra 
Published: April 2013

BackgroundAnxiety constitutes the most common form of psychopathology in childhood and adolescence.MethodsThis randomised controlled study evaluated the ‘FRIENDS for Life’ school‐based Cognitive Behavioural Therapy programme on overall anxiety, anxiety subtypes and school adjustment. Sixty‐two students aged 12–13 completed measures of anxiety and school adjustment before, immediately after and 4 months after completing the programme. Parents and teachers also rated the students on overall anxiety levels and school adjustment respectively.ResultsThe intervention group's ‘overall anxiety’ and specifically ‘separation anxiety’ reduced significantly during the programme and continued to decrease at the 4‐month follow‐up.ConclusionsA significant negative correlation was found between anxiety and school adjustment. The professional implications of these findings are discussed.
Synthesis and Cytotoxic Evaluation of Acylated Brefeldin A Derivatives as Potential Anticancer Agents
Authors: He Bingyong , Wang Yajun , Zheng Yuguo , Chen Wei , Zhu Qing 
Published: April 2013

Brefeldin A has attracted considerable attention because of its potential function in cancer prevention. However, its therapeutic use is limited by its poor bioavailability. The modifications on brefeldin A were difficult because of its low stability and selectivity toward two hydroxyl groups within the same molecule. In this study, we report the selective acylation of brefeldin A under mild conditions and the preparation of a series of monoacylated and diacylated brefeldin A derivatives. Their cytotoxicity, antitumor activity against TE‐1 cell, and molecular properties of adsorption, distribution, metabolism, and elimination were evaluated. Brefeldin A 7‐O‐benzoate, brefeldin A 4,7‐O‐dibenzoate, and brefeldin A 7‐O‐biotin carboxylate showed the most potent cytotoxic activity, with GI50 values of 0.39, 0.46, and 0.50 μm, respectively. Molecular docking of these analogs revealed that the derivatives were well tolerated at the interface between ARF1 and its guanine nucleotide exchange factor ARNO. Our results may serve as a basis for the development of novel potential anticancer agents from brefeldin A derivatives.
Telomere shortening by mutations in the RTEL1 helicase cause severe form of dyskeratosis congenita, Hoyerall‐Hreidarsson syndrome
Authors: Lee JW 
Published: April 2013

Germline mutations of regulator of telomere elongation helicase 1, RTEL1, in Dyskeratosis congenitalBallew et al. (2013)Journal of Human Genetics 132: 473–480.Constitutional mutations in RTEL1 cause severe dyskeratosis congenitaWalne et al. (2013)American Journal of Human Genetics 92 (3): 448–453.
Brokerage and the Making of Middle Indonesia
Authors: van KLINKEN GERRY 
Published: April 2013

AbstractIndonesia is the world's fourth most populous nation, extending 5,000 km west to east. Its grand myth of national becoming, the Revolution of 1945, intended to weld together a disparate colonial patchwork, stands in uneasy contrast with the spatial unevenness of its actual history of national integration. Socially speaking, there are two Indonesias: a central Indonesian heartland that owned the revolution and much other mobilizational activity before and since, and an eastern Indonesian periphery that heard about these things from afar and was otherwise preoccupied with its own affairs. Yet Indonesia is united. This paper explores the role of mediation in the “action at a distance” problem of political power. The brokers who brought eastern Indonesia into the new nation came from small towns in the region. The paper traces the biography of one of the main nationalist organizers in one small provincial town in eastern Indonesia at the time when the nation was born. He and his fellows opened doors for central government officials and for fellow locals wanting government jobs. Untroubled by demands from local civil society, they bequeathed factional bureaucratic politics to the town, rather than democracy.
Reinventing a Model Socialist Steel Town in the Neoliberal Economy: The Case ofNowaHuta,Poland
Authors: POZNIAK KINGA 
Published: April 2013

AbstractThis article examines how a former Polish industrial town reinscribes its past and reinvents its public image in the context of simultaneous political and economic changes.NowaHuta was originally built as the country's model socialist town. Then, following the collapse of the socialist government and the adoption of democratic and neoliberal economic reforms, it experienced both deindustrialization and political marginalization on account of its association with the previous regime. This article examines current initiatives aimed at revitalizing the town's economy and public image. It argues that the process of reinventing and revitalizingNowaHuta has many parallels with deindustrializing cities across theNorthAtlantic. At the same time, inPoland this process is additionally inflected by the country's socialist legacy. The article thus aims to elucidate how processes such as deindustrialization, globalization and neoliberalism are worked out in concrete places and with relation to local politics and histories.
Narrow‐band imaging with dual focus magnification in differentiating colorectal neoplasia
Authors: Singh Rajvinder , Jayanna Mahesh , Navadgi Suresh , Ruszkiewicz Andrew , Saito Yutaka , Uedo Noriya 
Published: April 2013

BackgroundReal‐time optical diagnosis of colorectal polyps may lead to substantial time and cost savings and could potentially reduce complications associated with polypectomy. We prospectively assessed the utility of a novel narrow‐band imaging (NBI) system with dual focus magnification (DF) in differentiating colorectal polyps in consecutive patients undergoing colonoscopy.Patients and MethodsAll procedures were carried out with a prototype 190 series Exera III NBI system with Dual Focus capability. Histology of each polyp was predicted in real time with NBI‐DF based on the modified Sano's classification with a confidence level (low/high). NBI‐DF diagnosis was then compared to the final (blinded) histopathology results. Primary endpoint was the accuracy of endoscopic prediction with the modified Sano's classification of all polyps when they were diagnosed with high confidence. Secondary endpoints were the accuracy of post‐polypectomy surveillance intervals for diminutive polyps(≤5 mm). A total of 164 polyps in 87 patients (53 males) with a mean age of 63 (range 28–86) years were evaluated.Results149 polyps were diagnosed with high confidence on endoscopic prediction, out of which 80 were diminutive, 31 small (6–9 mm) and 38 large (>10 mm). Overall accuracy of NBI‐DF compared to final histopathology was 97%. The accuracy for post‐polypectomy surveillance interval based on the endoscopic prediction was 97%. The NPV for diminutive rectosigmoid polyps for adenomatous histology was 100%.ConclusionIn this preliminary feasibility study, NBI‐DF permitted prediction of histology of colorectal polyps with high accuracy. In addition, both of the secondary endpoints exceeded the ASGE PIVI thresholds for the management of diminutive polyps.
Newly designed plastic stent for endoscopic placement above the sphincter of Oddi in patients with malignant hilar biliary obstruction
Authors: Ishiwatari Hirotoshi , Hayashi Tsuyoshi , Ono Michihiro , Sato Tsutomu , Kato Junji 
Published: April 2013

BackgroundPlastic stent (PS) occlusion occurs as a result of bacterial adherence to the stent's inner wall. To retain the bacteriological barrier, placing a PS above the sphincter of Oddi (‘inside stent’) has been investigated. We designed a new PS (inside stent with thread [IT] stent) with attachable nylon thread for use as an inside stent and for easy retrieval. The present study evaluated the IT stent's technical feasibility and efficacy for malignant hilar biliary obstruction.Patients and MethodsA total of 26 consecutive patients with unresectable malignant hilar biliary obstruction underwent placement of IT stents from August 2007 to February 2011. IT stents were placed across the strictures without sphincterotomy to achieve bilateral drainage.ResultsThe overall technical success rate of the IT stent was 100% for one session. Multiple IT stents were inserted in 25 cases(two stents in 15 patients, three stents in 10 patients). No stent‐related early complications occurred. The functional success rate was 92% (24/26). The rate of reintervention because of stent malfunction was 50% (13/26). In all 16 patients who underwent stent removal, IT stents were easily retrieved using the nylon thread. According to Kaplan–Meier analysis, the median stent patency period was 136 days.ConclusionIT stents for endoscopic placement above the sphincter of Oddi can be used safely and effectively for malignant hilar biliary obstruction.
Life history of anadromous burbot (Lota lota, Linneaus) in the brackish Baltic Sea inferred from otolith microchemistry
Authors: Rohtla Mehis , Vetemaa Markus , Taal Imre , Svirgsden Roland , Urtson Kristjan , Saks Lauri , Verliin Aare , Kesler Martin , Saat Toomas 
Published: April 2013

AbstractStrontium to calcium (Sr:Ca) and barium to calcium (Ba:Ca) ratios were quantified in 74 otoliths of brackish water‐living burbot Lota lota, collected from two regions in the eastern Baltic Sea. Considerable amount of life history plasticity was observed. Ninety‐six per cent of analysed burbot were of freshwater origin; only three specimens displayed signs of hatching in low‐salinity (1–2) estuarine environment. Most of the juveniles emigrated from freshwater during late winter and spring the next year after birth, while nine individuals did so at the age of 2–3 months. Age and length at maturity (as determined by first freshwater spawning migration) varied from 2–6 years and 189–540 mm, respectively, with most of burbot maturing during the second or third year of life. It is hypothesised that the bulk juvenile downstream migration is triggered by high‐flow conditions as evidenced by Ba:Ca peak around the point of freshwater exit. This study provides new information on burbot life history.
Reward sensitivity modulates connectivity among reward brain areas during processing of anticipatory reward cues
Authors: Costumero Victor , Barrós‐Loscertales Alfonso , Bustamante Juan C. , Ventura‐Campos Noelia , Fuentes Paola , Ávila César 
Published: April 2013

AbstractReward sensitivity, or the tendency to engage in motivated approach behavior in the presence of rewarding stimuli, may be a contributory factor for vulnerability to disinhibitory behaviors. Although evidence exists for a reward sensitivity‐related increased response in reward brain areas (i.e. nucleus accumbens or midbrain) during the processing of reward cues, it is unknown how this trait modulates brain connectivity, specifically the crucial coupling between the nucleus accumbens, the midbrain, and other reward‐related brain areas, including the medial orbitofrontal cortex and the amygdala. Here, we analysed the relationship between effective connectivity and personality in response to anticipatory reward cues. Forty‐four males performed an adaptation of the Monetary Incentive Delay Task and completed the Sensitivity to Reward scale. The results showed the modulation of reward sensitivity on both activity and functional connectivity (psychophysiological interaction) during the processing of incentive cues. Sensitivity to reward scores related to stronger activation in the nucleus accumbens and midbrain during the processing of reward cues. Psychophysiological interaction analyses revealed that midbrain–medial orbitofrontal cortex connectivity was negatively correlated with sensitivity to reward scores for high as compared with low incentive cues. Also, nucleus accumbens–amygdala connectivity correlated negatively with sensitivity to reward scores during reward anticipation. Our results suggest that high reward sensitivity‐related activation in reward brain areas may result from associated modulatory effects of other brain regions within the reward circuitry.