bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol Inhibits Nasopharyngeal Carcinoma (NPC) by Targeting the MAPK Signaling Pathway
Authors: Yi Yujuan , Zhou Bo , Man Tengjun , Xu Zihan , Tang Hong , Li Jia , Sun Zheng 
Published: July 2024

Background:
With conventional cancer treatments facing limitations, interest in plant-derived natural
products as potential alternatives is increasing. Although resveratrol has demonstrated antitumor effects in various
cancers, its impact and mechanism on nasopharyngeal carcinoma remain unclear

Objective:
This study aimed to systematically investigate the anti-cancer effects of resveratrol on nasopharyngeal
carcinoma using a combination of experimental pharmacology, network pharmacology, and molecular docking
approaches.

Methods:
Resveratrol inhibited the proliferation, invasion, and migration of nasopharyngeal carcinoma cells, ultimately
inducing apoptosis in a time- and dose-dependent manner. Network pharmacology analysis revealed that
resveratrol may exert its anti-nasopharyngeal carcinoma effect mainly through the MAPK pathway. Immunohistochemistry
results from clinical cases showed MAPK signaling activation in nasopharyngeal carcinoma tissues
compared to adjacent tissues. Western blotting validated the targeting effect of resveratrol, demonstrating
significant inhibition of the MAPK signaling pathway. Furthermore, molecular docking supported its multi-target
role with MAPK, TP53, PIK3CA, SRC, etc.

Results:
Resveratrol inhibited the proliferation, invasion, and migration of nasopharyngeal carcinoma cells, ultimately inducing apoptosis in a time- and dose-dependent manner. Network pharmacology analysis revealed that
resveratrol may exert its anti-nasopharyngeal carcinoma effect mainly through the MAPK pathway. Immunohistochemistry results from clinical cases showed MAPK signaling activation in nasopharyngeal carcinoma tissues compared to adjacent tissues. Western blotting validated the targeting effect of resveratrol, demonstrating
significant inhibition of the MAPK signaling pathway. Furthermore, molecular docking supported its multi-target
role with MAPK, TP53, PIK3CA, SRC, etc.

Conclusion:
Resveratrol has shown promising potential in inhibiting human nasopharyngeal carcinoma cells by
primarily targeting the MAPK pathway. These findings position resveratrol as a potential therapeutic agent for
nasopharyngeal carcinoma.
Portuguese Version of the Oral Frailty Index-8: Instrument Validation Study
Authors: Corrêa Laura , Júdice André , Scoz Robson , Machado Vanessa , Mendes José João , Proença Luís , Botelho João , Ferreira Luciano 
Published: July 2024

Background
The concept of oral frailty has gained scientific and clinical relevance in recent years, and early detection can facilitate timely intervention to manage its progression. The Oral Frailty Index-8 (OFI-8) was developed to assess community-dwelling older adults at risk for oral frailty.

Objective
This study aims to investigate the psychometric validity of the OFI-8 in the Portuguese population, named the Portuguese version of the OFI-8 (OFI-8-PT), which may serve as a reference for future studies related to longevity and oral function.

Methods
This study included 2 main phases, involving patients aged 60 years or older, Portuguese speakers, and those who consented to participate in the study. First, the researchers translated and cross-culturally adapted the original questionnaire to make it suitable for native Portuguese speakers. The translated tool was then assessed for psychometric validation, which consisted of test-retest reliability, internal consistency, construct validity, and sex invariance measurement.

Results
A total of 159 older adults participated in the baseline survey, with almost equal numbers of male (n=79, 49.7%) and female participants (n=80, 50.3%). The OFI-8-PT demonstrated good reliability (Cronbach α=0.95) and construct validity (goodness-of-fit index=0.96; comparative fit index=0.85; and root mean square error of approximation=0.05, 90% CI 0.00-0.09). The study found sex invariance, indicating that the OFI-8-PT is equally valid for male and female participants, and the tested-retest reliability of the OFI-8-PT was good, indicating consistent results over time.

Conclusions
The OFI-8-PT showed psychometric validity and good reliability to be used in the Portuguese population.
Machine Learning Model for Anesthetic Risk Stratification for Gynecologic and Obstetric Patients: Cross-Sectional Study Outlining a Novel Approach for Early Detection
Authors: Tsai Feng-Fang , Chang Yung-Chun , Chiu Yu-Wen , Sheu Bor-Ching , Hsu Min-Huei , Yeh Huei-Ming 
Published: July 2024

Background
Preoperative evaluation is important, and this study explored the application of machine learning methods for anesthetic risk classification and the evaluation of the contributions of various factors. To minimize the effects of confounding variables during model training, we used a homogenous group with similar physiological states and ages undergoing similar pelvic organ–related procedures not involving malignancies.

Objective
Data on women of reproductive age (age 20-50 years) who underwent gestational or gynecological surgery between January 1, 2017, and December 31, 2021, were obtained from the National Taiwan University Hospital Integrated Medical Database.

Methods
We first performed an exploratory analysis and selected key features. We then performed data preprocessing to acquire relevant features related to preoperative examination. To further enhance predictive performance, we used the log-likelihood ratio algorithm to generate comorbidity patterns. Finally, we input the processed features into the light gradient boosting machine (LightGBM) model for training and subsequent prediction.

Results
A total of 10,892 patients were included. Within this data set, 9893 patients were classified as having low anesthetic risk (American Society of Anesthesiologists physical status score of 1-2), and 999 patients were classified as having high anesthetic risk (American Society of Anesthesiologists physical status score of >2). The area under the receiver operating characteristic curve of the proposed model was 0.6831.

Conclusions
By combining comorbidity information and clinical laboratory data, our methodology based on the LightGBM model provides more accurate predictions for anesthetic risk classification.

Trial Registration
Research Ethics Committee of the National Taiwan University Hospital 202204010RINB; https://www.ntuh.gov.tw/RECO/Index.action
Islamic Education and Gender Equality
Authors: Hairiyah Hairiyah , Sirait Sangkot , Arif Mahmud 
Published: July 2024

This article discusses the importance of education, particularly Islamic Religious Education, in addressing gender issues and inequalities faced by women in various aspects of life. Gender, as a social construction, is different from biological sex and plays an important role in social and cultural dynamics. This research, which is descriptive-critical in nature, uses a literature approach to analyze data sources and related literature. The main focus is on how education, especially Islamic religious education, can be used as a tool to combat ingrained gender prejudices and stereotypes in society. Islamic Educationis seen as a means to spread the values of equality, freedom, democracy and justice, and to overcome gender-biased interpretations of religious texts. The article emphasizes the importance of an inclusive and gender justice based curriculum in shaping young people's attitudes and understanding of gender issues. This includes addressing gender stereotypes in educational materials and promoting critical thinking among students. In addition, this article highlights the need to recognize that the challenges in realizing gender equality lie not only in education, but also in social and cultural practices. Therefore, it is proposed that gender justice-based Islamic Educationcan be a catalyst in promoting a more balanced and inclusive understanding of gender roles, which is essential for the development of a more tolerant, just and egalitarian society.
Biologi Reproduksi Ikan Selais Terang Bulan (Kryptopterus bicirrhis, Valenciennes 1840) Di Desa Mentulik Sungai Kampar Kiri, Provinsi Riau
Authors: Nopiri Ria , Elvyra Roza 
Published: July 2024

Penelitian Biologi Reproduksi ikan selais Terang Bulan (Kryptopterus bicirrhis) di Desa Mentulik Sungai Kampar Kiri dilaksanakan pada bulan Februari â€“ Juli 2017. Adapun tujuan penelitian yaitu untuk mengkaji aspek reproduksi ikan K. bicirrhis meliputi nisbah kelamin, perkembangan gonad, fekunditas, musim pemijahan dan juga pola pemijahan. Ikan K. bicirrhis yang didapatkan berjumlah 40 ekor terdiri dari 30 ekor ikan jantan dan 10 ekor ikan betina, dengan nisbah kelamin 3 : 1. Rerata panjang dan berat total tubuh ikan jantan adalah 8,2-11,5 cm (2,47-5,31 g) dan ikan betina 8,4-11,5 cm (2,64-5,05 g), dengan pola pertumbuhan bersifat allometrik negatif. Tingkat Kematangan Gonad (TKG) ikan jantan dan betina ditemukan pada tahap TKG II-IV. Fekunditas telur K. bicirrhis berjumlah 10.657 butir, dan memiliki pola pemijahan yang bersifat total spawner.
Identification of factors that influence carbon emissions in tropical peatland
Authors: Yahya Vanda Julita , Sabiham Supiandi , Pramudya Bambang , Las Irsal 
Published: July 2024

Penelitian bertujuan untuk mengetahui hubungan curah hujan terhadap tinggi muka air tanah. Serta pengaruh faktor kimia (kadar air gambut, pH) dan fisika (kapasitas tukar kation) terhadap emisi CO2. Penelitian menggunakan analisis matematika sederhana dengan menggunakan data sekunder. Dilakukan di perkebunan kelapa sawit di Kecamatan Koto Gasib, Kabupaten Siak, Riau. Obyek yang diteliti tinggi muka air tanah, curah hujan dan faktor kimia-fisika lahan gambut di perkebunan kelapa sawit. Hasil penelitian menunjukan bahwa curah hujan dan hari hujan mempunyai hubungan linier dengan tinggi muka air tanah. Tinggi muka air tanah berkontribusi 71.48% terhadap emisi GRK dan 28.52% dipengaruhi faktor lain. pH tanah gambut berkontribusi 91.41 %, terhadap emisi, 8.59% dipengaruhi faktor lain. Pengaruh KTK terhadap emisi sebesar 88.66 %, dan 11.34% dipengaruhi faktor lain. Kandungan air gambut berpengaruh 96.19% terhadap emisi GRK, dan 3.81 % dipengaruhi faktor lain. Kesimpulan tinggi muka air tanah, kadar air, pH dan KTK berpengaruh sangat nyata terhadap emisi CO2.
Analisis Jumlah Bakteri Pasta Gigi Cangkang Anadara granosa yang Diberi Citrus medica Dengan Waktu Penyimpanan Yang Berbeda
Authors: Solang Margaretha , Hasan Marwan , Kumaji Syam S. 
Published: July 2024

Penelitian ini bertujuan menganalisis bakteri pasta gigi cangkang Anadara granosa yang diberi perasan Citrus medica dengan waktu penyimpanan yang berbeda. Penelitian ini menggunakan metode rancangan acak lengkap (RAL) terdiri dari dua faktor yaitu faktor volume perasan Citrus medica dengan taraf perlakuan 0 mL, 2 mL, 4 mL dan 6 mL serta faktor lama penyimpanan dengan taraf perlakuan 1 hari, 7 hari, 14 hari, 21 hari dan 28 hari, dengan 6 kali ulangan.Â Perhitungan bakteri menggunakan metode hitungan cawan (TPC). Analisis data menggunakan Analisis Varians Two Way dan dilanjutkan dengan uji DMRT taraf 5%. Hasil penelitian menunjukkan bahwa pemberian perasan Citrus medica dengan waktu penyimpanan yang berbeda berinteraksi secara signifikan (p=0,00) terhadap jumlah bakteri pasta gigi cangkang kerang darah. Pasta gigi cangkang Anadara granosa yang diberi perasan Citrus medica 6 mL dan disimpan 28 hari memiliki jumlah bakteri 9.0 x 101, jumlah bakteri ini masih dalam batasan yang ditetapkan Standar Nasional Indonesia (SNI).
Uji Efektivitas Ekstrak Etanol Kulit Jeruk Sunkist (Citrus sinensis (L.) Osbeck) Terhadap Kadar Gula Darah Tikus Wistar (Rattus norvegicus) dengan Hiperkolesterolemia yang di Induksi Streptozotocin.
Authors: Depari Sania Angelisa F , Rambe Daffa Jihan Azmi , Meilando Rifki , Lisya Cut , Mutia Maya Sari , Lubis Yolanda Eliza Putri 
Published: July 2024

Kondisi kadar gula darah yang tinggi pada penderita diabetes ternyata memicu peningkatan LDL dan penurunan HDL dimana pada orang dengan diabetesâ€energi yang didapatkan tubuh berasal dari penguraian lemak dan metabolisme protein. Kulit jeruk Sunkist (Citrus sinensis (L.) Osbeck) dilaporkan memiliki aktivitas antidiabetik, antihiperkolesterolemia, antiinflamasi serta antioksidan . Penelitian ini bertujuan untuk mengetahui efektivitas dari ekstrak etanol kulit jeruk Sunkist (Citrus sinensis (L.) Osbeck) terhadap kadar gula darah pada dosis 500, 750 dan 1000 mg/kgBB. Penelitian ini menggunakan rancangan penelitian True Experimental Pre-Test and Post-Test Control Group Design dimana kulit jeruk Sunkist yang diekstraksi dengan metode maserasi diberikan secara oral selama 14 hari pada tikus wistar hiperkolesterolemia yang diinduksi streptozotocin. Hasil pengujian statistik menunjukkan bahwa ekstrak etanol kulit jeruk Sunkistâ€mampu menurunkan kadar gula darah dan kadar kolesterol tikus wistar hiperkolesterolemia yang diinduksi streptozotocin (p<0,05). Dosis ekstrak etanol kulit jeruk Sunkist yang paling efektif dalam menurunkan kadar gula darah dan kadar kolesterol tikus wistar hiperkolesterolemia yangâ€diinduksi streptozotocin adalah 1000mg/kgBB.
Studi Etnobotani Rotan Sebagai Bahan Kerajinan Anyaman Pada Suku Anak Dalam (SAD) di Dusun III Senami, Desa Jebak, Kabupaten Batanghari, Jambi.
Authors: Jumiati Jumiati , Hariyadi Bambang , Murni Pinta 
Published: July 2024

Rattan is one of the non-timber forest products that has been widely used by traditional communities for various purposes such as a woven material, rigging purposes, and for other purposes. Suku Anak Dalam, SAD, is a group of indigenous people in Jambi Popinsi who still maintain a close relationship with the surrounding forests.Â The group waves rattan to produce variousrattan craft.Â This study aims to inventory the diversity of rattan species being used to prduce rattan craft and to document knowledge associated with rattan waving.Â The study was undertaken in the village of Jebak, Batanghari Regency, Jambi Province. Data collected through a semi-structured interviews and participant observation. The results indicate the presence of 10 species of rattan commonly used to manufacture various unique SAD rattan craft. The SAD produces at leart18 types of woven rattan for various purposes.
Keanekaragaman Jenis Burung pada Areal Tambak Intensif di Sumatera Selatan dan Lampung
Authors: Master Jani , Nurcahyani Nuning , Natalia Suci , Pertiwi Henny Indah 
Published: July 2024

Abstrak. Areal pertambakan merupakan salah satu habitat yang disukai oleh jenis burung, khususnya burung air. Penelitian ini ini bertujuan untuk indentifikasi keanekaragaman jenis-jenis burung yang terdapat pada areal pertambakan udang intensif. Penelitian dilakukan pada dua areal tambak intensif terbesar di Sumatera Selatan dan Lampung pada bulan Juni â€“ Agustus 2014. Metode penelitian yang digunakan adalah metode jelajah dengan stasiun pengamatan yang ditempatkan secara purposive. Hasil pengamatan menunjukkan bahwa tingkat keanekaragaman burung pada dua areal tambak intensif berkisar antara sedang hingga tinggi yaitu 2,90 untuk tambak intesif di Sumatera SelatanÂ dan 3.55 untuk tambak intensif di Lampung. Areal tambak menjadi salah satu lokasi penting bagi burung, selain karena memiliki keanekaragaman jenis yang tinggi, areal tambak juga menjadi salah satu habitat pilihan lokasi singgah mencari makan burung-burung migran. Â Kata Kunci: keanekaragaman jenis, burung air, tambak udang
Instrumental and Visual Evaluation of the Chameleon Effect of Single-shaded Composite Resins
Authors: Adiguzel RM , Kose LK , Arhun N 
Published: July 2024

SUMMARY

Objective:
To evaluate the shade-matching ability of single-shade resin-based composite restorations in different thicknesses using both instrumental and visual techniques.

Methods and Materials:
Cavities with 4 mm diameter and 2 mm (n=96) or 3 mm (n=96) depth were prepared in acrylic incisor teeth of shades A2, A3, B3, and C2 and restored with three single-shade resin composites, Omnichroma (Tokuyama Dental America, Encinitas, CA, USA [OM]), Vittra APS Unique (FGM Dental Group, Joinville, SC, Brazil [VU]), Zenchroma (President Dental, Allershausen, Germany [ZC]), and a microhybrid resin composite (Filtek 3M Z250 3M ESPE, St Paul, MN, USA [FZ]) of A2, A3, B3, and C2 shades. Readings were obtained using VITA Easyshade V spectrophotometer for the teeth and restorations. The CIEDE2000 (ΔE00) color difference formula was used, and the values were assessed using three-way analysis of variance (ANOVA). Forty-eight evaluators graded the shade match of 32 different specimens visually as (A) best shade match, (B) intermediate shade match, and (C) poor shade match.

Results:
FZ material achieved satisfactory matches for both thicknesses, across all shades, and OM material demonstrated statistically significant lower shade matches than the ZC and the FZ materials (p&lt;0.05). VU exhibited poor shade match with the highest ΔE00 value on C2 shade. According to the visual examination, the best shade matches were observed for FZ on A3-shade and ZC on C2-shade teeth.

Conclusions:
Shade matching for 2 mm and 3 mm-thick composite resin restorations is material- and tooth-shade dependent.
Theobromine for Remineralization of White Spot Lesions on Dental Enamel: A Systematic Review and Meta-analysis
Authors: Silva ARJ da , Gonçalves RI dos Santos , Catão MHC de Vasconcelos 
Published: July 2024

SUMMARY

Aim:
This systematic review and meta-analysis evaluated theobromine’s (Theobroma cacao) potential in remineralizing white spot lesions in dental enamel. Methods: This study is reported according to the PRISMA checklist and was registered in PROSPERO (CRD42023414371). In vitro tests that evaluated the remineralizing potential of theobromine compared to fluoride ion after demineralization for the formation of white spot lesions on enamel were selected, with no limitation on the year of publication. Electronic searches were performed in PubMed/MEDLINE, Scopus, and Web of Science by two independent researchers. Thirty articles were received of which six were selected according to the inclusion criteria.

Results:
The selected studies evaluated the Enamel Surface Microhardness (SMH), Vickers or Knoop, before and after treatment with theobromine and fluoride solutions. For the SMH Vickers, there were no differences between groups at baseline (p=1.00; mean difference: -0.00; CI: -11.36 to 11.36) and after treatment (p=0.51; mean difference: 4.12; CI: -8.16 to 16.41). The results of SMH Knoop showed differences between groups at baseline, favoring the experimental group (p=0.002; mean difference: 9.84; CI: 3.65 to 16.02) and after treatment favoring the control group (p=0.00001; mean difference: -5.45; CI: -7.62 to -3.27).

Conclusion:
The use of theobromine increases the microhardness of dental enamel subjected to a demineralization process, thus being effective in the remineralization of this tissue with success equivalent to that obtained with the use of fluoride.
Diagnosis and Management of Labor Dystocia According to the Friedman Curve
Authors: Winata I Gde Sastra , Putri Tjokorda Istri Agung Devitia Widya Paramita , Pradnyandari Anak Agung Ayu Vidya 
Published: July 2024

Introduction: Labor dystocia or abnormal prolonged delivery is one of the common indications regarding unplanned cesarean deliveries. A better understanding of the diagnosis and management of labor dystocia according to friedman curve could lead to new opportunities to increase the rate of vaginal delivery. This paper aims to summarize known diagnosis and management techniques according to the Friedman curve. Method: Literature reviews were compiled based on article obtained using search engine “Google Scholar” and “PubMed” with keywords “Diagnosis", “Friedman Curve”, “Labor”, “Dystocia” and “Management”. There were 10 articles that were appropriate for this purpose. Result and discussion: Labor dystocia is a labor complication where the labor process is abnormally slow or prolonged, hence the term abnormal prolonged labor. This involves a variety of problem which is abbreviated by three P’s, Power, Passage and Passenger. Power is defined by the ability of the uterus to contract during labor. Passage is defined as divergence between the measurements of the fetal head and the maternal pelvis that might be caused by ineffective uterine contraction or macrosomic fetus, so that result in obstructed labor. Passenger is defined as the presentation, position and fetal development that might influence the dystocia incident. Labor dystocia is one of the common indication regarding unplanned caesarian deliveries. Therefore, early diagnosis and management of labor dystocia is crucial in improving outcome in labor dystocia patients, both for the mother and the newborn. Conclusion: Labor is influenced by multiple factors related to the mother and fetus. The theories of Friedman and recent advancements have significantly impacted the diagnosis of protraction or arrest disorder. In challenging situations, timely identification and suitable management are crucial. Educating patients about labor preparation is vital to prevent adverse conditions that can lead to complications and even mortality for both mother and fetus.
Examination of the thickness of the different components of gallbladder wall in cases with mucocele and/or cholecystitis
Authors: Azuma Kazushi , Mason Gary , Monnet Eric 
Published: July 2024

Abstract

OBJECTIVE
To assess the thickness of each layer of the gallbladder wall with different diseases in dogs.

SAMPLE
72 gallbladders.

METHODS
Retrospective study of dogs that underwent cholecystectomy. Histopathological specimens of the gallbladders were reviewed. Histopathological diagnosis was made as gallbladder mucocele or cholecystitis, and cholecystitis was further categorized into chronic cholecystitis, acute-on-chronic cholecystitis, acute cholecystitis, and necrotic cholecystitis. The thickness of each layer of the gallbladder wall was measured.

RESULTS
22 dogs were diagnosed with gallbladder mucocele without cholecystitis, 24 with gallbladder mucocele and cholecystitis, 20 with only cholecystitis, and 6 as normal. Histopathological subclassification of cholecystitis in 44 gallbladders led to diagnosis of chronic cholecystitis in 21 gallbladders, acute-on-chronic cholecystitis in 10 gallbladders, acute cholecystitis in 6 gallbladders, and necrotic cholecystitis in 7 gallbladders. The thickness of the entire wall of the gallbladder (P < .0001) and the thickness of the mucosa (P < .0001) and subserosa (P < .0001) were affected by the different disease processes.

CLINICAL RELEVANCE
Layers of the gallbladder wall were affected by diseases present in the gallbladder. It resulted in a difference in the thickness of the wall of the gallbladder among the gallbladder diseases in this study. Histopathological changes should be taken into consideration before surgery while deciding what technique to use to perform a cholecystectomy.
Current therapy and advancements in the treatment of equine fungal keratitis
Authors: Roberts Darby M. , Gilger Brian C. 
Published: July 2024

Abstract
Equine fungal keratitis represents a substantial portion of keratitis cases in horses, with fungal involvement identified in approximately half of all infectious keratitis cases. Despite its prevalence, more comprehensive retrospective analyses are needed to better understand this condition. Outcomes vary, with approximately two-thirds of cases achieving complete healing with retained vision, although enucleation is often necessary. Predominant pathogens include Aspergillus and Fusarium, with yeast reported in a minority of cases. Resistance to common antifungal agents among filamentous fungi poses a significant challenge. Advances in diagnostics, including repeat culture and antifungal susceptibility testing, as well as the incorporation of PCR technology, hold promise for improving detection and guiding treatment decisions. Newer antifungals, combination therapies, and innovative modalities such as photodynamic therapy offer hope for improved outcomes. Continued research efforts are essential to further elucidate the epidemiology, pathogenesis, and optimal management strategies for this condition.