bluuebunny/crossref_metadata_2025_split huggingface dataset:
The association between asthma control, health care costs, and quality of life in France and Spain
Authors: Doz Marianne , Chouaid Christos , Com-Ruelle Laure , Calvo Eduardo , Brosa Max , Robert Julien , Decuypère Laurent , Pribil Celine , Huerta Alicia , Detournay Bruno 
Published: March 2013

Abstract

Background
Current asthma management guidelines are based on the level of asthma control. The impact of asthma control on health care resources and quality of life (QoL) is insufficiently studied. EUCOAST study was designed to describe costs and QoL in adult patients according to level of asthma control in France and Spain.

Methods
An observational cost of illness study was conducted simultaneously in both countries among patients age greater or equal to 18 with a diagnosis of asthma for at least 12 months. Patients were recruited prospectively by GPs in 2010 in four waves to avoid a seasonal bias. Health care resources utilization of the three months before the inclusion was collected through physician questionnaires. Asthma control was evaluated using 2009 GINA criteria over a 3-month period. QoL was assessed using EQ-5D-3L®.

Results
2,671 patients (France: 1,154; Spain: 1,517) were enrolled. Asthma was controlled in 40.6% [95% CI: 37.7% - 43.4%] and 29.9% [95% CI: 27.6% - 32.3%] of French and Spanish patients respectively.
For all types of costs, the percentage of patients using health care resources varied significantly according to the level of asthma control. The average cost (euros/3-months/patient) of controlled asthma was €85.4 (SD: 153.5) in France compared with €314.0 (SD: 2,160.4) for partially controlled asthma and €537.9 (SD: 2,355.7) for uncontrolled asthma (p<0.0001). In Spain, the corresponding figures were €152.6 (SD: 162.1), €241.2 (SD: 266.8), and €556.8 (SD: 762.4). EQ-5D-3L® score was higher (p<0.0001) in patients with controlled asthma compared to partially controlled and uncontrolled asthma in both countries (respectively 0.88; 0.78; 0.63 in France and 0.89; 0.82; 0.69 in Spain).

Conclusions
In both countries, patients presenting with uncontrolled asthma had a significantly higher asthma costs and lower scores of Qol compared to the others.
Intervention of Electroacupuncture on Spinal p38 MAPK/ATF-2/VR-1 Pathway in Treating Inflammatory Pain Induced by CFA in Rats
Authors: Fang Jian-Qiao , Du Jun-Ying , Liang Yi , Fang Jun-Fan 
Published: March 2013

Background Previous studies have demonstrated that p38 MAPK signal transduction pathway plays an important role in the development and maintenance of inflammatory pain. Electroacupuncture (EA) can suppress the inflammatory pain. However, the relationship between EA effect and p38 MAPK signal transduction pathway in inflammatory pain remains poorly understood. It is our hypothesis that p38 MAPK/ATF-2/VR-1 and/or p38 MAPK/ATF-2/COX-2 signal transduction pathway should be activated by inflammatory pain in CFA-injected model. Meanwhile, EA may inhibit the activation of p38 MAPK signal transduction pathway. The present study aims to investigate that anti-inflammatory and analgesic effect of EA and its intervention on the p38 MAPK signal transduction pathway in a rat model of inflammatory pain. Results EA had a pronounced anti-inflammatory and analgesic effect on CFA-induced chronic inflammatory pain in rats. EA could quickly raise CFA-rat's paw withdrawal thresholds (PWTs) and maintain good and long analgesic effect, while it subdued the ankle swelling of CFA rats only at postinjection day 14. EA could down-regulate the protein expressions of p-p38 MAPK and p-ATF-2, reduced the numbers of p-p38 MAPK-IR cells and p-ATF-2-IR cells in spinal dorsal horn in CFA rats, inhibited the expressions of both protein and mRNA of VR-1, but had no effect on the COX-2 mRNA expression. Conclusions The present study indicates that inhibiting the activation of spinal p38 MAPK/ATF-2/VR-1 pathway may be one of the main mechanisms via central signal transduction pathway in the process of anti-inflammatory pain by EA in CFA rats.
Paradoxical impairment of angiogenesis, endothelial function and circulating number of endothelial progenitor cells in DPP4-deficient rat after critical limb ischemia
Authors: Sun Cheuk-Kwan , Leu Steve , Sheu Jiunn-Jye , Tsai Tzu-Hsien , Sung Hsin-Chin , Chen Yung-Lung , Chung Sheng-Ying , Ko Sheung-Fat , Chang Hsueh-Wen , Yip Hon-Kan 
Published: March 2013

Abstract
Introduction
We hypothesized that dipeptidyl peptidase-IV (DPP4) may impair angiogenesis, endothelial function, and the circulating number of endothelial progenitor cells (EPC) in a model of critical limb ischemia (CLI) through ligating the left femoral artery using DPP4-deficient rats.

Methods
Adult male DPP4-deficient (DPP4D) rats (n = 18) were equally divided into CLI only (DPP4D-CLI) and CLI treated by granulocyte colony-stimulating factor (GCSF) (DPP4D-CLI-GCSF). For comparison, age-matched wild-type (WT) Fischer 344 rats (n = 18) were randomized into two groups receiving identical treatment compared to their DPP4-deficient counterparts and labeled as WT-CLI (n = 9) and WT-CLI-GCSF (n = 9), respectively.

Results
The circulating number of EPCs (CD31+, CD34+, CD133, C-kit+) was significantly lower in DPP4-deficient than in WT rats on post-CLI days 1 and 4 (all P < 0.01). The ratio of ischemia/normal blood flow was remarkably lower in DPP4D-CLI-GCSF rats than in WT-CLI-GCSF animals on post-CLI Day 14 (all P < 0.01). Protein expressions of pro-angiogenic factors (endothelial nitric oxide synthase (eNOS), CXCR4, SDF-1α, vascular endothelial growth factor (VEGF)) were remarkably higher in WT-CLI than in DPP4D-CLI rats, and higher in WT-CLI-GCSF than in DPP4D-CLI-GCSF animals (all P < 0.01). Moreover, the numbers of small vessel in the ischemic area were substantially higher in WT-CLI-GCSF than in DPP4D-CLI-GCSF rats (P < 0.001). Furthermore, vasorelaxation and nitric oxide production of the normal femoral artery were significantly reduced in DPP4-deficient than in WT Fischer rats (all P < 0.01).

Conclusions
Contrary to our hypothesis, DPP4-deficient rats were inferior to age-matched WT Fischer rats in terms of angiogenesis, endothelial function, circulating EPC number and response to GCSF, suggesting a positive role of DPP4 in maintaining vascular function and tissue perfusion in this experimental setting.
On the generation of low frequencies with modern seismic vibrators
Authors: Wei Zhouhong , Phillips Thomas F. 
Published: March 2013

Acquiring low-frequency seismic data using Vibroseis techniques has gained attention in recent years. Successful application of low-frequency Vibroseis acquisition requires evaluating each element of the data acquisition system and ensuring that each part of the system contributes to the success of the method. We focus on generating low frequencies with Vibroseis sources rather than recording and preserving them. To generate the low-frequency signals using seismic vibrators, it is better to know (1) the hydraulic and mechanical system of the vibrator; (2) the design of a low-frequency sweep that can deliver the vibrator ground force maximally; and (3) the vibrator control system that can minimize the harmonic distortion of the vibrator ground force output at low frequencies. Field tests show that hydraulic pump flow is not a limiting factor for the generation of the low frequencies for most modern seismic vibrators. In addition, with harmonic distortion reduction control, the vibrator performance at low frequencies is improved.
Risk assessment and shared care planning in out-patient forensic psychiatry: cluster randomised controlled trial
Authors: Troquete Nadine A. C. , van den Brink Rob H. S. , Beintema Harry , Mulder Tamara , van Os Titus W. D. P. , Schoevers Robert A. , Wiersma Durk 
Published: March 2013

BackgroundForensic psychiatry aims to reduce recidivism and makes use of risk assessment tools to achieve this goal. Various studies have reported on the predictive qualities of these instruments, but it remains unclear whether their use is associated with actual prevention of recidivism in clinical care.AimsTo test whether an intervention combining risk assessment and shared care planning is associated with a reduction in violent and criminal behaviour.MethodA cluster randomised controlled trial (Netherlands Trial Register number NTR1042) was conducted in three outpatient forensic psychiatric clinics. The intervention comprised risk assessment with the Short Term Assessment of Risk and Treatability (START) and a shared care planning protocol formulated according to shared decision-making principles. The control group received usual care. The outcome consisted of the proportion of clients with violent or criminal incidents at follow-up.ResultsIn total 58 case managers and 632 of their clients were included, in the intervention group (n=310), 65% received the intervention at least once. Findings showed a general treatment effect (22% of clients with an incident at baselinev.15% at follow-up,P<0.01) but no significant difference between the two treatment conditions (odds ratio (OR)=1.46, 95% CI 0.89-2.44,P= 0.15).ConclusionsAlthough risk assessment is common practice in forensic psychiatry, our results indicate that the primary goal of preventing recidivism was not reached through risk assessment embedded in shared decision-making.
Concanavalin-A Induces Granulosa Cell Death and Inhibits FSH-Mediated Follicular Growth and Ovarian Maturation in Female Rats
Authors: Velasquez Ethel V. , Ríos Mariana , Ortiz María Elena , Lizama Carlos , Nuñez Elizabeth , Abramovich Dalhia , Orge Felipe , Oliva Barbara , Orellana Renán , Villalon Manuel , Moreno Ricardo D. , Tesone Marta , Rokka Anne , Corthals Garry , Croxatto Horacio B. , Parborell Fernanda , Owen Gareth I. 
Published: March 2013

Abstract
Reproductive success stems from a finely regulated balance between follicular maturation and atresia, in which the role of carbohydrate structure is poorly understood. Here, we describe for the first time a fraction of purified recombinant human FSH that is capable of bringing about the cell death of granulosa cells and preventing follicular maturation in a rat model. Further analysis by mass spectrometry revealed the presence of the lectin Concanavalin-A (Con-A) within this fraction of recombinant FSH. Using both the fractionated FSH and Con-A, the observed cell death was predominantly located to the granulosa cells. Ex vivo culture of rat follicles demonstrated that follicle degeneration occurred and resulted in the release of a denuded and deteriorated oocyte. Moreover, in vivo experiments confirmed an increase in atresia and a corresponding reduction confined to follicle in early antral stage. As a mechanism of action, Con-A reduces ovarian proliferation, Von Willebrand staining, and angiogenesis. Based on the observation that Con-A may induce granulosa cell death followed by follicle death, our results further demonstrate that follicular carbohydrate moiety is changing under the influence of FSH, which may allow a carbohydrate-binding lectin to increase granulosa cell death. The physiological consequences of circulating lectin-like molecules remain to be determined. However, our results suggest a potential exploitation of carbohydrate binding in fertility and ovarian cancer treatment. This work may shed light on a key role of carbohydrates in the still obscure physiological process of follicular selection and atresia.
Excessive Sympathoactivation and Deteriorated Heart Function After Myocardial Infarction in Male Ghrelin Knockout Mice
Authors: Mao Yuanjie , Tokudome Takeshi , Otani Kentaro , Kishimoto Ichiro , Miyazato Mikiya , Kangawa Kenji 
Published: March 2013

Abstract
We have previously demonstrated the protective role of endogenous ghrelin against malignant arrhythmias in the very acute phase of myocardial infarction (MI). However, the role of endogenous ghrelin in the chronic phase is unknown. Therefore, the aim of the current study was to focus on the effects of endogenous ghrelin on cardiac function and sympathetic activation after acute MI. In 46 ghrelin-knockout (KO) and 41 wild-type (WT) male mice, MI was produced by left coronary artery ligation. The mortality due to heart failure within 2 weeks was 0% in WT and 10.9% in KO (P &lt; 0.05). At the end of this period, lung weight/tibial length, atrial natriuretic peptide and brain natriuretic peptide transcripts, end-systolic and end-diastolic volumes were all significantly greater in KO mice, whereas systolic function, represented by ejection fraction (16.4 ± 4.7% vs 25.3 ± 5.1%), end-systolic elastance, and preload-recruitable stroke work, was significantly inferior to that in WT mice (P &lt; 0.05). Telemetry recording and heart rate variability analysis showed that KO mice had stronger sympathetic activation after MI than did WT mice. Metoprolol treatment and ghrelin treatment in KO mice prevented excessive sympathetic activation, decreased plasma epinephrine and norepinephrine levels, and improved heart function and survival rate after MI. Our data demonstrate that endogenous ghrelin plays a crucial role in protecting heart function and reducing mortality after myocardial infarction, and that these effects seem to be partly the result of sympathetic inhibition.
Nanoceria-catalyzed Highly Efficient Procedure for N-Formylation of Amines at Room Temperature under Solvent-free Conditions
Authors: Patil Umakant B , Singh Abhilash S , Nagarkar Jayashree M 
Published: March 2013

Abstract
Nanoceria-catalyzed simple and efficient protocol for the N-formylation of amines using formic acid at room temperature under solvent-free conditions shows high yield of desired product chemoselectivity and improvement in reaction time.
Microstructure and Room-temperature H2 Sensing Properties of Undoped and Impurity-doped SnO2 Nanowires
Authors: Shen Yanbai , Wei Dezhou , Li Mingyang , Liu Wengang , Gao Shuling , Han Cong , Cui Baoyu 
Published: March 2013

Abstract
We demonstrate the microstructure and room-temperature H2 sensing properties of undoped, Pt-doped, and Pd-doped SnO2 nanowires (SNWs). SNWs with a tetragonal structure were synthesized by thermal evaporation of tin grains at 900 °C. Gas sensors based on undoped, Pt-doped, and Pd-doped SNWs showed a reversible response to H2 at room temperature. The response was improved in the order undoped &lt; Pt-doped &lt; Pd-doped SNWs under the same conditions.
Controlled Formation of Microspheres from Ferrocene-derivatized Amino Acids in Binary Aqueous/Organic Media
Authors: Morikawa Masa-aki , Murata Ken , Yamada Kazuo , Kimizuka Nobuo 
Published: March 2013

Abstract
A novel amino acid derivative having two ferrocene units spontaneously forms regular microspheres in binary aqueous/tetrahydrofuran (THF) media. The size of the microspheres is controllable from nano to micro dimensions depending on the concentration and composition of the binary solvent. These microspheres display reversible redox properties, as characterized by cyclic voltammetry.
Copper-catalyzed 1,4-Addition Reaction of Grignard Reagent to Enones Using Microflow System
Authors: Katayama Haruo , Matsubara Seijiro 
Published: March 2013

Abstract
The copper-catalyzed conjugate addition of a Grignard reagent to an α,β-unsaturated ketone was performed in a microflow system. In the reaction using the microflow system, a chemoselective 1,4-addition reaction to an enone in the presence of a saturated ketone group proceeded successfully.
In Vitro Stability of Free and Glucuronidated Cannabinoids in Blood and Plasma Following Controlled Smoked Cannabis
Authors: Scheidweiler Karl B , Schwope David M , Karschner Erin L , Desrosiers Nathalie A , Gorelick David A , Huestis Marilyn A 
Published: March 2013

BACKGROUND
Blood and plasma cannabinoid stability is important for test interpretation and is best studied in authentic rather than fortified samples.

METHODS
Low and high blood and plasma pools were created for each of 10 participants after they smoked a cannabis cigarette. The stabilities of Δ9-tetrahydrocannabinol (THC), 11-hydroxy-THC (11-OH-THC), 11-nor-9-carboxy-THC (THCCOOH), cannabidiol (CBD), cannabinol (CBN), THC-glucuronide, and THCCOOH-glucuronide were determined after 1 week at room temperature; 1, 2, 4, 12, and 26 (±2) weeks at 4 °C; and 1, 2, 4, 12, 26 (±2), and 52 (±4) weeks at −20 °C. Stability was assessed by Friedman test.

RESULTS
Numbers of THC-glucuronide and CBD-positive blood samples were insufficient to assess stability. In blood, 11-OH-THC and CBN were stable for 1 week at room temperature, whereas THC and THCCOOH-glucuronide decreased and THCCOOH increased. In blood, THC, THCCOOH-glucuronide, THCCOOH, 11-OH-THC, and CBN were stable for 12, 4, 4, 12, and 26 weeks, respectively, at 4 °C and 12, 12, 26, 26, and 52 weeks at −20 °C. In plasma, THC-glucuronide, THC, CBN, and CBD were stable for 1 week at room temperature, whereas THCCOOH-glucuronide and 11-OH-THC decreased and THCCOOH increased. In plasma, THC-glucuronide, THC, THCCOOH-glucuronide, THCCOOH, 11-OH-THC, CBN, and CBD were stable for 26, 26, 2, 2, 26, 12, and 26 weeks, respectively, at 4 °C and 52, 52, 26, 26, 52, 52, and 52 weeks, respectively, at −20 °C.

CONCLUSIONS
Blood and plasma samples should be stored at −20 °C for no more than 3 and 6 months, respectively, to assure accurate cannabinoid quantitative results.
Clinical Utility and Analytical Challenges in Measurement of Cerebrospinal Fluid Amyloid-β1–42 and τ Proteins as Alzheimer Disease Biomarkers
Authors: Kang Ju-Hee , Korecka Magdalena , Toledo Jon B , Trojanowski John Q , Shaw Leslie M 
Published: March 2013

BACKGROUND
Over the past 2 decades, clinical studies have provided evidence that cerebrospinal fluid (CSF) amyloid β1–42 (Aβ1–42), total τ (t-τ), and τ phosphorylated at Thr181 (p-τ181) are reliable biochemical markers of Alzheimer disease (AD) neuropathology.

CONTENT
In this review, we summarize the clinical performance and describe the major challenges for the analytical performance of the most widely used immunoassay platforms [based on ELISA or microbead-based multianalyte profiling (xMAP) technology] for the measurement of CSF AD biomarkers (Aβ1–42, t-τ, and p-τ181). With foundational immunoassay data providing the diagnostic and prognostic values of CSF AD biomarkers, the newly revised criteria for the diagnosis of AD include CSF AD biomarkers for use in research settings. In addition, it has been suggested that the selection of AD patients at the predementia stage by use of CSF AD biomarkers can improve the statistical power of clinical trial design. Owing to the lack of a replenishable and commutable human CSF-based standardized reference material (SRM) and significant differences across different immunoassay platforms, the diagnostic–prognostic cutpoints of CSF AD biomarker concentrations are not universal at this time. These challenges can be effectively met in the future, however, through collaborative ongoing standardization efforts to minimize the sources of analytical variability and to develop reference methods and SRMs.

SUMMARY
Measurements of CSF Aβ1–42, t-τ, and p-τ181 with analytically qualified immunoassays reliably reflect the neuropathologic hallmarks of AD in patients at the early predementia stage of the disease and even in presymptomatic patients. Thus these CSF biomarker tests are useful for early diagnosis of AD, prediction of disease progression, and efficient design of drug intervention clinical trials.
Yoga for the New Woman and the New Man: The Role of Pierre Bernard and Blanche DeVries in the Creation of Modern Postural Yoga
Authors: Laycock Joseph 
Published: March 2013

AbstractPierre Bernard and his wife, Blanche DeVries, were among the earliest proponents of postural yoga in America. In 1924, they created the Clarkstown Country Club, where yoga was taught to affluent and influential clientele. The network created through this endeavor not only popularized yoga in the West but also advanced the reinvention of yoga as a science of health and well-being rather than as a religious practice.This article suggests that the pair's success in marketing yoga coincided with a shift in gender roles underway at the turn of the century. Economic and cultural changes led to the rise of a “New Woman” who was not only more financially independent but also more socially and sexually autonomous. At the same time, a crisis of masculinity led to the rise of the “New Man” as men sought out new cultural forms through which to restore their sense of manhood. Bernard's success depended largely on his ability to capitalize on the perceived “otherness” of yoga, presenting it as a resource for Americans seeking to construct new forms of gender identity. Bernard borrowed from the physical culture movement and presented yoga as an antidote to the emasculating effects of modern society. DeVries taught a combination of yoga and sensual Orientalist dances that offered women a form of sexual autonomy and embodied empowerment. By utilizing these strategies, Bernard and DeVries helped lay important foundations for modern postural yoga and its associations with athleticism, physical beauty, and sexuality.
Promoting the Well-Being of Children Whose Parents Are Gay or Lesbian
Authors:   COMMITTEE ON PSYCHOSOCIAL ASPECTS OF CHILD AND FAMILY HEALTH, Siegel Benjamin S. , Perrin Ellen C. , Pawelski James G. , Siegel Benjamin S. , Dobbins Mary I. , Lavin Arthur , Mattson Gerri , Pascoe John , Yogman Michael , Siegel Benjamin S. , Perrin Ellen C. , Pawelski James G. , Siegel Benjamin S. , Dobbins Mary I. , Lavin Arthur , Mattson Gerri , Pascoe John , Yogman Michael , Brown Ronald T. ,   Society of Pediatric Psychology, Kupst Mary Jo ,   Society of Pediatric Psychology, Martini D. Richard ,   American Academy of Child, Psychiatry Adolescent , Blue Barbara ,   PMHNP-BC,   National Association of Pediatric Nurse Practitioners, Carmichael Terry ,   National Association of Social Workers, Cohen George J. , Domain Stephanie , Smith Karen 
Published: March 2013

This Policy Statement was reaffirmed September 2022.
To promote optimal health and well-being of all children, the American Academy of Pediatrics (AAP) supports access for all children to (1) civil marriage rights for their parents and (2) willing and capable foster and adoptive parents, regardless of the parents’ sexual orientation. The AAP has always been an advocate for, and has developed policies to support, the optimal physical, mental, and social health and well-being of all infants, children, adolescents, and young adults. In so doing, the AAP has supported families in all their diversity, because the family has always been the basic social unit in which children develop the supporting and nurturing relationships with adults that they need to thrive. Children may be born to, adopted by, or cared for temporarily by married couples, nonmarried couples, single parents, grandparents, or legal guardians, and any of these may be heterosexual, gay or lesbian, or of another orientation. Children need secure and enduring relationships with committed and nurturing adults to enhance their life experiences for optimal social-emotional and cognitive development. Scientific evidence affirms that children have similar developmental and emotional needs and receive similar parenting whether they are raised by parents of the same or different genders. If a child has 2 living and capable parents who choose to create a permanent bond by way of civil marriage, it is in the best interests of their child(ren) that legal and social institutions allow and support them to do so, irrespective of their sexual orientation. If 2 parents are not available to the child, adoption or foster parenting remain acceptable options to provide a loving home for a child and should be available without regard to the sexual orientation of the parent(s).