bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigations on the interactions of DiAmsar with serum albumins: Insights from spectroscopic and molecular docking techniques
Authors: Hooshyar Zari , Rezanejade Bardajee Ghasem , Kakavand Nahaleh , Khanjari Mohaddeseh , Dianatnejad Nastaran 
Published: October 2014

AbstractDiamine‐sarcophagine (DiAmsar) binding to human serum albumin (HSA) and bovine serum albumin (BSA) was investigated under simulative physiological conditions. Fluorescence spectra in combination with Fourier transform infrared (FT‐IR), UV‐visible (UV–vis) spectroscopy, cyclic voltammetry (CV), and molecular docking method were used in the present work. Experimental results revealed that DiAmsar had an ability to quench the HSA and BSA intrinsic fluorescence through a static quenching mechanism. The Stern–Volmer quenching rate constant (Ksv) was calculated as 0.372 × 103 M‐1 and 0.640 × 103 M‐1 for HSA and BSA, respectively. Moreover, binding constants (Ka), number of binding sites (n) at different temperatures, binding distance (r), and thermodynamic parameters (∆H°, ∆S°, and ∆G°) between DiAmsar and HSA (or BSA) were calculated. DiAmsar exhibited good binding propensity to HSA and BSA with relatively high binding constant values. The positive ∆H° and ∆S° values indicated that the hydrophobic interaction is main force in the binding of the DiAmsar to HSA (or BSA). Furthermore, molecular docking results revealed the possible binding site and the microenvironment around the bond. Copyright © 2014 John Wiley & Sons, Ltd.
‘In Our Country it's Just Poor People who Ride a Bike’: Place, Displacement and Cycling in Australia
Authors: Law Siew Fang , Karnilowicz Wally 
Published: October 2014

AbstractThis study investigates relationships and characteristics of participation in cycling in Melbourne, Australia, as an expression of place and displacement among persons from culturally and linguistically diverse origins including Asia (i.e. Vietnam, Sri Lanka and Japan) and Arab Africa (i.e. Saudi Arabia, Eritrea and Sudan). Using a mixed‐method approach, results indicated that despite a significant number of migrants to Australia with origins in places where cycling is a common mode of transport and activity, a large number of newly arrived and marginalised migrants and refugees are less likely to engage in cycling. Cyclists' identity, citizenship, social‐economic marginalisation and residential geographic isolation significantly impacted on their cycling in Melbourne. Although cycling is considered accessible, environmentally friendly, healthy and functional, the results indicated that this view may only represent and be shared by selected citizens. In short, culturally and linguistically diverse participants identified cycling behaviour differently in Australia in comparison with cycling in their countries of origin. The results contribute to knowledge in highlighting the extent of displacement facing marginalised communities that evolves in everyday practices of local mobility. The study identified a number of paradoxes facing mainstream policy makers, researchers and cycling advocates who tend to take cycling participation for granted as non‐political and universal. Copyright © 2014 John Wiley & Sons, Ltd.
The use of Web 2.0 technologies in marketing classes: Key drivers of student acceptance
Authors: Lowe Ben , D'Alessandro Steven , Winzar Hume , Laffey Des , Collier William 
Published: October 2014

ABSTRACTWith the proliferation in Web 2.0 technologies, many marketing educators are experimenting with new teaching and learning tools (e.g. Facebook, Twitter, YouTube and Second Life). The benefits of such technologies are often touted by scholars, and indeed, there is a good deal of evidence to support such a view. However, increasingly, educators are highlighting some of the limitations of technology in the learning environment. To draw parallels with other new product research in marketing, the adoption of new learning technologies is often not so widespread. The literature exhibits inconsistency about the willingness of students to adopt new technology in a learning environment, but no systematic research into the factors that affect technology acceptance yet exists. This research fills a gap in the literature by applying an augmented Technology Acceptance Model (TAM) to understand students' future intentions to adopt Twitter, a Web 2.0 technology shown to offer students a variety of benefits. By using partial least squares, the research shows that the main proximal driver of student adoption of Twitter is a utilitarian attitude. Students need to be convinced about ‘what's in it for me’, rather than persuaded about the technology's hedonic benefits. Other affective variables such as an individual's affinity with computers and risk tolerance were also found to be important drivers of perceived ease of use and perceived usefulness, the TAM's key antecedents. Copyright © 2013 John Wiley & Sons, Ltd.
Non‐Invasive Probing of Nanoparticle Electrostatics
Authors: Tschulik Kristina , Cheng Wei , Batchelor‐McAuley Christopher , Murphy Stuart , Omanović Dario , Compton Richard G. 
Published: October 2014

AbstractElectrostatic interactions between surface‐charged nanoparticles (NPs) and electrodes studied using existing techniques unavoidably and significantly alter the system being analyzed. Here we present a methodology that allows the probing of unperturbed electrostatic interactions between individual NPs and charged surfaces. The uniqueness of this approach is that stochastic NP impact events are used as the probe. During a single impact, only an attomole of the redox species reacts and is released at the interface during each sensing event. As an example, the effect of electrostatic screening on the reduction of negatively charged indigo NPs at a mercury microelectrode is explored at potentials positive and negative of the potential of zero charge. At suitable overpotentials fully driven electron transfer is seen for all but very low (<0.005 M) ionic strengths. The loss of charge transfer in such dilute electrolytes is unambiguously shown to arise from a reduced driving force for the reaction rather than a reduced population of NPs near the electrode, contradicting popular perceptions. Electrostatics were found not to significantly affect the reactivity of the studied NPs. Importantly, the presented technique is general and can be applied to a wide variety of NPs, including metals, metal oxides and organic compounds.
A Systematic Study on the Stability of Porous Coordination Polymers against Ammonia
Authors: Kajiwara Takashi , Higuchi Masakazu , Watanabe Daisuke , Higashimura Hideyuki , Yamada Teppei , Kitagawa Hiroshi 
Published: October 2014

AbstractTo establish a strategy for designing porous coordination polymers (PCPs) for ammonia capture, the first systematic study on the stability of PCPs against ammonia was conducted. Various types of PCPs were investigated by comparing their powder XRD patterns before and after treatment with ammonia. Among the PCPs tested, ZIF‐8, MIL‐53(Al), Al‐BTB, MOF‐76(M) (M=Y or Yb), MIL‐101(Cr), and MOF‐74(Mg) were stable up to 350 °C under an ammonia atmosphere at ambient pressure. The origin of the stability of PCPs is discussed from the viewpoint of their components, metal cations, and organic linkers. Furthermore, adsorption isotherm measurements show that the adsorptive behavior of PCPs is independent of their stability.
The First Five‐Membered‐Heterocycle‐Fused Subphthalocyanine Analogues: Chiral Tri(benzo[b]thiopheno)subporphyrazines
Authors: Shang Hong , Zhao Luyang , Qi Dongdong , Chen Chao , Jiang Jianzhuang 
Published: October 2014

AbstractTwo tri(benzo[b]thiopheno)subporphyrazine regioisomers with C3 and C1 molecular symmetry have been isolated from the cyclotrimerization of benzo[b]thiophene‐2,3‐dicarbonitrile as the first five‐membered‐heterocycle‐fused subphthalocyanine analogues. Optical resolution of both regioisomers was achieved by using a chiral HPLC technique, affording the first chiral subphthalocyanine analogues.
A versatile and facile surface modification route based on polydopamine for the growth of MOF films on different substrates
Authors: Zhu He , Zhu Shiping 
Published: October 2014

AbstractThin MOF‐5 films were grown from various substrates, which were modified by polydopamine – a bio‐inspired multi‐functional coating. A MOF‐5 mother solution was used. These supports included polypropylene (PP) fibrous membranes, PP porous membranes, and aluminum foils. SEM and XRD were used to characterize the prepared MOF films. The unmodified substrates did not support the growth of MOF films with MOF particles sparsely scattered on the surfaces. In contrast, the polydopamine‐modified substrates were fully covered with a dense layer of MOF crystals. Polydopamine was proven to be very useful in the surface modification that facilitated the growth of MOF films on the substrate materials.
Clinical and pathologic features of familial pancreatic cancer
Authors: Humphris Jeremy L. , Johns Amber L. , Simpson Skye H. , Cowley Mark J. , Pajic Marina , Chang David K. , Nagrial Adnan M. , Chin Venessa T. , Chantrill Lorraine A. , Pinese Mark , Mead R. Scott , Gill Anthony J. , Samra Jaswinder S. , Kench James G. , Musgrove Elizabeth A. , Tucker Katherine M. , Spigelman Allan D. , Waddell Nic , Grimmond Sean M. , Biankin Andrew V. ,   the Australian Pancreatic Cancer Genome Initiative
Published: October 2014

BACKGROUNDInherited predisposition to pancreatic cancer contributes significantly to its incidence and presents an opportunity for the development of early detection strategies. The genetic basis of predisposition remains unexplained in a high proportion of patients with familial PC (FPC).METHODSClinicopathologic features were assessed in a cohort of 766 patients who had been diagnosed with pancreatic ductal adenocarcinoma (PC). Patients were classified with FPC if they had ≥1 affected first‐degree relatives; otherwise, they were classified with sporadic PC (SPC).RESULTSThe prevalence of FPC in this cohort was 8.9%. In FPC families with an affected parent‐child pair, 71% in the subsequent generation were 12.3 years younger at diagnosis. Patients with FPC had more first‐degree relatives who had an extrapancreatic malignancy (EPM) (42.6% vs 21.2; P<.0001), particularly melanoma and endometrial cancer, but not a personal history of EPM. Patients with SPC were more likely to be active smokers, have higher cumulative tobacco exposure, and have fewer multifocal precursor lesions, but these were not associated with differences in survival. Long‐standing diabetes mellitus (>2 years) was associated with poor survival in both groups.CONCLUSIONSFPC represents 9% of PC, and the risk of malignancy in kindred does not appear to be confined to the pancreas. Patients with FPC have more precursor lesions and include fewer active smokers, but other clinicopathologic factors and outcome are similar to those in patients with SPC. Furthermore, some FPC kindreds may exhibit anticipation. A better understanding of the clinical features of PC will facilitate efforts to uncover novel susceptibility genes and the development of early detection strategies. Cancer 2014;120:3669–3675. © 2014 American Cancer Society.
Intracallosal neuronal nitric oxide synthase neurons colocalize with neurokinin 1 substance P receptor in the rat
Authors: Barbaresi Paolo , Mensà Emanuela , Lariccia Vincenzo , Desiato Genni , Fabri Mara , Gratteri Santo 
Published: October 2014

ABSTRACTThe corpus callosum (cc) contains nitric oxide (NO)‐producing neurons. Because NO is a potent vasodilator, these neurons could translate neuronal signals into vascular responses that can be detected by functional brain imaging. Substance P (SP), one of the most widely expressed peptides in the CNS, also produces vasomotor responses by inducing calcium release from intracellular stores through its preferred neurokinin 1 (NK1) receptor, thus inducing NO production via activation of neuronal NO synthase (nNOS). Single‐ and double‐labeling experiments were performed to establish whether NK1‐immunopositive neurons (NK1IP‐n) are found in the rat cc and the extent of NK1 colocalization with nNOS. NK1IP‐n were seen to constitute a large neuronal population in the cc and had a distribution similar to that of nNOSIP neurons (nNOSIP‐n). NK1IP‐n were numerous in the lateral cc and gradually decreased in the more medial portions, where they were few or absent. Intracallosal NK1IP‐n and their dendritic trees were intensely labeled, allowing classification into four morphological types: bipolar, round, polygonal, and pyramidal. Confocal microscopic examination demonstrated that nearly all NK1IP‐n contained nNOS (96.43%) and that 84.59% of nNOSIP‐n co‐expressed NK1. These data suggest that the majority of intracallosal neurons can release NO as a result of the action of SP. A small proportion of nNOSIP‐n does not contain NK1 and is not activated by SP; these neurons may release NO via alternative mechanisms. The possible mechanisms by which intracallosal neurons release NO are also reviewed. J. Comp. Neurol. 523:589–607, 2015. © 2014 Wiley Periodicals, Inc.
Thermoresponsive Polymer Nanoparticles Based on Viologen Cavitands
Authors: Sultanova Elza D. , Krasnova Ekaterina G. , Kharlamov Sergey V. , Nasybullina Gulnaz R. , Yanilkin Vitaly V. , Nizameev Irek R. , Kadirov Marsil K. , Mukhitova Rezeda K. , Zakharova Lucia Y. , Ziganshina Albina Y. , Konovalov Alexander I. 
Published: October 2014

AbstractIn this study, the synthesis of new thermoactive polymer nanoparticles with a hollow and porous structure is reported. The nanoparticles consist of viologen cavitands linked with styrene bridges. The sizes of the nanoparticles and their pores are sensitive to temperature change. The temperature increase results in the swelling of the nanoparticles and in an increase in the permeability of the nanoparticle shell. The nanoparticles are characterized by the data of NMR, IR, and UV spectroscopies, and dynamic and static light scattering (DLS, SLS). The electrochemical behavior of the nanoparticles was investigated with cyclic voltammetry. The nanoparticles can be applied to the temperature‐controlled binding and release of substrates as shown by the fluorescent dye rhodamine B. The nanoparticles encapsulate and release rhodamine B in response to the change in temperature from 25 to 40 °C.
A grass–fire cycle eliminates an obligate‐seeding tree in a tropical savanna
Authors: Bowman David M. J. S. , MacDermott Harry J. , Nichols Scott C. , Murphy Brett P. 
Published: October 2014

AbstractA grass–fire cycle in Australian tropical savannas has been postulated as driving the regional decline of the obligate‐seeding conifer Callitris intratropica and other fire‐sensitive components of the regional flora and fauna, due to proliferation of flammable native grasses. We tested the hypothesis that a high‐biomass invasive savanna grass drives a positive feedback process where intense fires destroy fire‐sensitive trees, and the reduction in canopy cover facilitates further invasion by grass. We undertook an observational and experimental study using, as a model system, a plantation of C. intratropica that has been invaded by an African grass, gamba (Andropogon gayanus) in the Northern Territory, Australia. We found that high grass biomass was associated with reduced canopy cover and restriction of foliage to the upper canopy of surviving stems, and mortality of adult trees was very high (>50%) even in areas with low fuel loads (1 t·ha−1). Experimental fires, with fuel loads >10 t·ha−1, typical of the grass‐invasion front, caused significant mortality due to complete crown scorch. Lower fuel loads cause reduced canopy cover through defoliation of the lower canopy. These results help explain how increases in grass biomass are coupled with the decline of C. intratropica throughout northern Australia by causing a switch from litter and sparse perennial grass fuels, and hence low‐intensity surface fires, to heavy annual grass fuel loads that sustain fires that burn into the midstorey. This study demonstrates that changes in fuel type can alter fire regimes with substantial knock‐on effects on the biota.
CD8+ T‐cell immunosurveillance constrains lymphoid premetastatic myeloid cell accumulation
Authors: Zhang Wang , Zhang Chunyan , Li Wenzhao , Deng Jiehui , Herrmann Andreas , Priceman Saul J. , Liang Wei , Shen Shudan , Pal Sumanta K. , Hoon Dave S.B. , Yu Hua 
Published: October 2014

Increasing evidence suggests that premetastatic niches, consisting mainly of myeloid cells, provide microenvironment critical for cancer cell recruitment and survival to facilitate metastasis. While CD8+ T cells exert immunosurveillance in primary human tumors, whether they can exert similar effects on myeloid cells in the premetastatic environment is unknown. Here, we show that CD8+ T cells are capable of constraining premetastatic myeloid cell accumulation by inducing myeloid cell apoptosis in C57BL/6 mice. Ag‐specific CD8+ T‐cell cytotoxicity against myeloid cells in premetastatic lymph nodes is compromised by Stat3. We demonstrate here that Stat3 ablation in myeloid cells leads to CD8+ T‐cell activation and increased levels of IFN‐γ and granzyme B in the premetastatic environment. Furthermore, Stat3 negatively regulates soluble Ag cross‐presentation by myeloid cells to CD8+ T cells in the premetastatic niche. Importantly, in tumor‐free lymph nodes of melanoma patients, infiltration of activated CD8+ T cells inversely correlates with STAT3 activity, which is associated with a decrease in number of myeloid cells. Our study suggested a novel role for CD8+ T cells in constraining myeloid cell activity through direct killing in the premetastatic environment, and the therapeutic potential by targeting Stat3 in myeloid cells to improve CD8+ T‐cell immunosurveillance against metastasis.
Ionic Liquid Based Approaches to Carbon Materials Synthesis
Authors: Xie Zai‐Lai , Su Dang Sheng 
Published: October 2014

AbstractIonic liquids (ILs) have attracted continuous interest because of their remarkable physicochemical properties, including high thermal and chemical stability, nonflammability, negligible vapor pressure, designable cation/anion pairs, electrical and ionic conductivity, low melting points, and affinity towards many compounds. These properties make ionic liquids valuable in the creation of new materials and new processes throughout almost the entire field of materials chemistry. An emerging field is the use of ionic liquids in carbon‐based nanomaterials. Initially, ionic liquids were used as self‐templating carbon sources for the generation of unusual carbon materials in which homogeneous heteroatom doping (e.g., N, B, S) can be accomplished fairly easily. Later, ionic liquids were recognized as suitable for use in the conversion of biomass into porous carbon materials, acting as both reaction media and porosity‐directing regulator. Such applications open the door towards the synthesis and accurate tuning of carbon nanostructures, for example, pore structure, morphology, heteroatom doping, and surface functionality. In addition, the hybridization of ionic liquids and nanocarbons enables the development of composites by combining the properties of the ionic liquid (e.g., ionic conductivity or catalytic activity) and those of a host (e.g., chemical or mechanical stability). Currently, although the research of this topic is rapidly expanding, the rational design and synthesis of carbon‐based materials, particularly their applications in energy storage and transformation, is still in its infancy. In this review, we focus on several aspects of ionic liquid derived carbons with the aim of shedding light on this new topic: 1) Ionic liquids as an advanced medium for carbon synthesis, 2) ionogels derived from nanocarbon, 3) ionic liquids as fluid precursors for functional carbons, and 4) ionic liquid derived carbons for heterogeneous catalysis.
High Adsorption Capacity for Cationic Dye Removal and Antibacterial Properties of Sonochemically Synthesized Ag2WO4 Nanorods
Authors: Dutta Dimple P. , Singh Anamika , Ballal Anand , Tyagi Avesh K. 
Published: October 2014

Abstractα‐Ag2WO4 nanorods with an average diameter of 15 to 25 nm and a surface area of ca. 115.0 ± 0.2 m2/g have been synthesized by a facile sonochemical technique. These nanorods have been used for the adsorption of various cationic dyes (rhodamine B, methylene blue, and malachite green) from aqueous solution. The adsorption process is fast, and ca. 100 % adsorption of a 20 ppm mixture of all three dyes occurs within 10 min. The adsorption process was studied by varying different regulating parameters such as the solution pH and the initial dye and Ag2WO4 concentrations, and the results were analyzed with various isotherm and kinetic models. The mechanistic pathway for the selective adsorption of cationic dyes has been explained through zeta potential studies. Moreover, the thermal regeneration of the sorbent was possible by furnace heating at 250 °C, and the nanorods were efficient for multicyclic use. X‐ray photoelectron spectroscopy (XPS) has been performed on the thermally regenerated samples to ascertain their surface purity. The Ag2WO4 nanorods have a bactericidal effect and are active against both Gram‐negative and ‐positive bacterial strains of Escherichia coli and Bacillus subtilis, respectively. However, the efficiency is more pronounced for Gram‐positive bacteria. Thus, these sonochemically synthesized Ag2WO4 nanorods have great potential for the treatment of dye industry effluents as a promising adsorbent for cationic dyes from aqueous solution and are also useful as an antibacterial agent.
A Tetradentate β‐Diiminato Ligand Containing Phenolate Substituents: Flexivalent Coordination to MnIII, CoIII, NiII, and CuII
Authors: Faraj Fadhil Lafta , Khaledi Hamid , Morimoto Yuma , Itoh Shinobu , Olmstead Marilyn M. , Ali Hapipah Mohd 
Published: October 2014

AbstractA functionalized β‐dialdimine was prepared, bearing a 3,3‐dimethylindoleninyl group at the meso‐position and two N‐phenolic groups. The structure contains three labile protons, which can be lost or migrate through tautomerism to provide an N2O2 coordination core. A number of divalent and trivalent metal ions (CuII, NiII, CoII/III, and MnIII) were accommodated inside the core, forming a series of intensely colored products consisting of a tricyclic MN2O2 chelate. In the resulting divalent metal complexes, the dialdimine ligand is deprotonated only at the two phenolic oxygen atoms and is thus dianionic, whereas in the trivalent metal complexes, the dialdiminato ligand is triply deprotonated. The copper and nickel complexes adopt square‐planar geometries, whereas in the trivalent cobalt and manganese complexes, two neutral ancillary ligands complete an octahedral geometry around the metal center. In each case, the denticity of the diimino–diiminato ligand is four. The electrochemical oxidation of the copper and nickel complexes was studied by cyclic voltammetry.
Concise Synthesis of Vesnarinone and Its Analogues by Using Pd‐Catalyzed C–N Bond‐Forming Reactions
Authors: See Yi Yang , Dang Tuan Thanh , Chen Anqi , Seayad Abdul Majeed 
Published: October 2014

AbstractAn efficient and concise synthesis of vesnarinone and its analogues from readily available starting materials and by using catalytic C–N bond‐forming reactions is reported. In this protocol, a homogeneous Pd‐catalyzed Buchwald–Hartwig amination and a supported Pd nanoparticles catalyzed aminocarbonylation were utilized as the two key reactions to prepare vesnarinone in an overall yield of 73 %. Sixteen analogues were also synthesized in up to 89 % overall yield.