bluuebunny/crossref_metadata_2025_split huggingface dataset:
Severe Cenani–Lenz syndrome caused by loss of LRP4 function
Authors: Kariminejad Ariana , Stollfuß Barbara , Li Yun , Bögershausen Nina , Boss Karin , Hennekam Raoul C.M. , Wollnik Bernd 
Published: May 2013

AbstractLimb patterning and growth are complex embryonic processes in which the elaborately orchestrated interplay of diverse endocrine and paracrine factors is crucial to limb integrity. LRP4 is a lipoprotein receptor known for its regulatory effects on LRP5‐ and LRP6‐mediated Wnt signaling, a pathway that plays a pivotal role in limb development. Recessive mutations in LRP4 have been shown to cause Cenani–Lenz syndrome, which is characterized by severe limb malformations, an unusual face, and renal abnormalities. We report on a child with severe Cenani–Lenz syndrome caused by a novel homozygous nonsense mutation in LRP4. The severity of the phenotype in a patient with absent residual LRP4 function may point to a genotype–phenotype correlation. © 2013 Wiley Periodicals, Inc.
Monoamniotic monochorionic twins discordant for noncompaction cardiomyopathy
Authors: Ng Dianna , Bouhlal Yosr , Ursell Philip C. , Shieh Joseph T.C. 
Published: May 2013

AbstractOccasionally “identical twins” are phenotypically different, raising the question of zygosity and the issue of genetic versus environmental influences during development. We recently noted monochorionic‐monoamniotic twins, one of which had an isolated cardiac abnormality, noncompaction cardiomyopathy, a condition characterized by cardiac ventricular hypertrabeculation. We examined the prenatal course and subsequent pathologic correlation since ventricular morphogenesis may depend on early muscular contraction and blood flow. The monochorionic‐monoamniotic female twin pair was initially identified since one fetus presented with increased nuchal translucency. Complete heart block was later identified in the fetus with nuchal translucency who did not survive after delivery. In contrast, the unaffected twin had normal cardiac studies both prenatally and postnatally. Pathologic analysis of the affected twin demonstrated noncompaction of the left ventricle with dysplasia of the aortic and pulmonary valves. Dissection of the cardiac conduction system disclosed atrioventricular bundle fibrosis. Maternal lupus studies, amniocentesis with karyotype, and studies for 22q11.2 were normal. To test for zygosity, we performed multiple STR marker analysis and found that all markers were shared even using nonblood tissues from the affected twin. These studies demonstrate that monozygotic twins that are monochorionic monoamniotic can be discordant for cardiac noncompaction. The results suggest further investigation into the potential roles of pathologic fibrosis, contractility, and blood flow in cardiac ventricle development. © 2013 Wiley Periodicals, Inc.
De novo 19p13.2 microdeletion encompassing the insulin receptor and resistin genes in a patient with obesity and learning disability
Authors: Wangensteen Teresia , Retterstøl Lars , Rødningen Olaug K. , Hjelmesæth Jøran , Aukrust Pål , Halvorsen Bente 
Published: May 2013

AbstractGenetic studies have provided novel insights of appetite regulation and pathophysiology of obesity. The adipose tissue is an active endocrine organ secreting several hormones contributing to insulin resistance and the development of the comorbidities of obesity, such as type 2 diabetes and cardiovascular disease. Herein, we report on a patient with severe obesity and mild learning disability with a 750 kb de novo deletion of chromosome 19. The deletion encompasses several genes, including resistin and the first part of the insulin receptor, genes that are relevant for obesity. This novel deletion may therefore represent a region for obesity research. Plasma analyses and gene expression demonstrated that the deletion resulted in haploinsufficiency for resistin and insulin receptor in the patient compared to controls. We then studied the biochemical and adipocytokine profile in these subjects. We observed no differences in glucose and lipid parameters between the patient and the controls. Thus, haploinsufficiency of insulin receptor and resistin does not appear to influence glucose and lipid metabolism. However, the patient had considerably higher values of adiponectin and TNFα than controls. In conclusion, we identified a 19p13.2 microdeletion encompassing the insulin receptor and resistin genes resulting in haploinsufficiency in an obese, but otherwise healthy patient. No firm conclusions could be drawn regarding the potential effect of the microdeletion on adipokine profile. © 2013 Wiley Periodicals, Inc.
Holocene footprints in Namibia: The influence of substrate on footprint variability
Authors: Morse Sarita A. , Bennett Matthew R. , Liutkus‐Pierce Cynthia , Thackeray Francis , McClymont Juliet , Savage Russell , Crompton Robin H. 
Published: May 2013

ABSTRACTWe report a Holocene human and animal footprint site from the Namib Sand Sea, south of Walvis Bay, Namibia. Using these data, we explore intratrail footprint variability associated with small variations in substrate properties using a “whole foot” analytical technique developed for the studies in human ichnology. We demonstrate high levels of intratrail variability as a result of variations in grain size, depositional moisture content, and the degree of sediment disturbance, all of which determine the bearing capacity of the substrate. The two principal trails were examined, which had consistent stride and step lengths, and as such variations in print typology were primarily controlled by substrate rather than locomotor mechanics. Footprint typology varies with bearing capacity such that firm substrates show limited impressions associated with areas of peak plantar pressure, whereas softer substrates are associated with deep prints with narrow heels and reduced medial longitudinal arches. Substrates of medium bearing capacity give displacement rims and proximal movement of sediment, which obscures the true form of the medial longitudinal arch. A simple conceptual model is offered which summarizes these conclusions and is presented as a basis for further investigation into the control of substrate on footprint typology. The method, model, and results presented here are essential in the interpretation of any sites of greater paleoanthropological significance, such as recently reported from Ileret (1.5 Ma, Kenya; Bennett et al.: Science 323 (2009) 1197–1201). Am J Phys Anthropol 151:265–279, 2013. © 2013 Wiley Periodicals, Inc.
Synthesis and characterization of microencapsulated sodium phosphate dodecahydrate
Authors: Wang Ting Yu , Huang Jin 
Published: May 2013

ABSTRACTMicrocapsules loaded with sodium phosphate dodecahydrate (DSP) were prepared according to the solvent evaporation method. The microencapsulated phase‐change materials (MEPCMs) possessed methyl methacrylate crosslinked with ethyl acrylate generated poly(methyl methacrylate) (PMMA) as the coating polymer. The influences of the polymerization time, polymerization temperature, and organic solvent types on the performances of the MEPCMs were studied in this report. The results indicate that the polymerization time and temperature had barely any effect on the size but a significant effect on the surface morphology of the microphase‐change materials. The solubility of the shell material varied in different organic solvents, and this to different phase‐transition enthalpies. In addition, DSP could be encapsulated well by PMMA, and the as‐prepared MEPCMs were equipped with a good morphology and a small particle size. When toluene and acetone were used as organic solvents, the MEPCMs had an interesting energy storage capacity of 142.9 J/g at 51.51°C, and this made them suitable for different applications. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 1516–1523, 2013
Polymer Brushes: Promises and Challenges
Authors: Yameen Basit , Farrukh Aleeza 
Published: May 2013

AbstractSurface‐tethered polymers, or “polymer brushes”, are emerging as key elements in the context of regulating the surface characteristics of materials. Their properties, such as biocompatibility, antifouling, colloidal stability, wettability, and corrosion resistance, play a vital role in ascertaining their potential applications. The availability of straightforward procedures for polymer brush synthesis, which are applicable to a wide range of monomers and are adaptable to a range of substrates, is a clear advantage over other surface‐modification strategies. Herein, the important advancements that are pertinent to the fabrication of polymer brushes are outlined. Furthermore, an exhaustive up‐to‐date overview of the developments in different application domains, including smart drug‐delivery systems, biosensing, antifouling, stimuli‐responsive surfaces, and ion‐conducting membranes, that benefit from the developments in the field of polymer brushes, is presented.
Effects of natural phytochemicals in Angelica sinensis (Danggui) on Nrf2‐mediated gene expression of phase II drug metabolizing enzymes and anti‐inflammation
Authors: Saw Constance Lay Lay , Wu Qing , Su Zheng‐Yuan , Wang Hu , Yang Yinhua , Xu Xiaoting , Huang Ying , Khor Tin Oo , Kong Ah‐Ng Tony 
Published: May 2013

ABSTRACTThe root of Angelica sinensis (Oliv.) Diels (abbreviated as AS) (Danggui) has a long history in Asian herbal medicine. Recently, it was demonstrated that AS possesses anti‐cancer and anti‐oxidant activities. Because the transcription factor Nrf2 mediates the expression of many cellular anti‐oxidative stress genes, including genes that are involved in phase II drug metabolism and anti‐oxidative stress, this study sought to investigate whether pure compounds from AS or an AS extract could activate antioxidant response element (ARE)‐mediated gene expression and induce anti‐inflammatory activities. Z‐Ligustilide (Ligu), 3‐butylidenephthalide (Buty) and CO2 supercritical fluid‐extracted lipophilic AS extract (SFE) were tested in HepG2‐C8 cells stabilized with ARE luciferase reporter gene. Ligu and Buty caused significant toxicity only at 100 μm. All three samples induced ARE‐luciferase activity; however, SFE at 8.5 µg/ml induced ARE‐luciferase activity 2–3 fold more potently than did either of the pure compounds. SFE also significantly increased the endogenous mRNA of Nrf2 and the Nrf2 target anti‐oxidative gene NAD(P)H dehydrogenase, quinone 1 (NQO1). The protein expression of NQO1 was also significantly induced by SFE. In RAW 264.7 cells, SFE suppressed lipopolysaccharide (LPS)‐induced IL‐1β and TNF‐α expression about 2 fold stronger than sulforaphane, whereas both pure compounds and SFE suppressed inflammatory nitric oxide (NO) production. In summary, this study demonstrates that AS has anti‐inflammatory effects and activates the Nrf2 pathway, which protects against oxidative stress. Copyright © 2013 John Wiley & Sons, Ltd.
Experimentelle Untersuchungen zum Querkrafttragverhalten von auskragenden Fahrbahnplatten unter Radlasten
Authors: Reißen Karin , Hegger Josef 
Published: May 2013

AbstractFür Brückenbauwerke im Bestand mit Fahrbahnplatten ohne Querkraftbewehrung lässt sich nach derzeit gültigen technischen Regeln oft keine ausreichende Querkrafttragfähigkeit nachweisen. Der aktuelle Ansatz zur Berechnung der Querkrafttragfähigkeit ohne Querkraftbewehrung wurde allerdings hauptsächlich aus Querkraftversuchen an einfeldrigen, gelenkig gelagerten Balken abgeleitet. Da bisher nur wenige Versuche zur Querkrafttragfähigkeit von Kragplatten unter konzentrierten Lasten vorliegen, wurde im Rahmen eines von der Bundesanstalt für Straßenwesen (BASt) geförderten Forschungsvorhabens deren Querkrafttragverhalten genauer analysiert. Neben der mitwirkenden Breite für Querkraft standen das Momenten‐Querkraft‐Verhältnis und der Einfluss einer geneigten Biegedruckzone im Vordergrund der experimentellen Untersuchungen.Experimental investigations on the shear‐bearing behaviour of bridge deck cantilever slabs under wheel loadsThe calculated shear capacity according to current design rules of a large number of existing concrete bridge deck slabs without shear reinforcement is not sufficient. However, the present design rules for the shear capacity of members without shear reinforcement were principally developed based on shear tests on simply supported single span beams. Since until now, only few tests on the shear capacity of cantilever slabs under concentrated loads have been conducted, the shear‐bearing behaviour of cantilever slabs has been analysed within a research programme funded by the Federal Highway Research Institute of Germany (BASt). Besides the effective width for shear, the moment‐shear relation and the influence of an inclined compression zone were experimentally investigated.
Mögliche Auswirkungen beim Einsatz fließfähiger Betone in massigen Bodenplatten
Authors: Neunzig Christian , Uebachs Stephan , Hinzen Marcus , Brameshuber Wolfgang 
Published: May 2013

AbstractMassige Bodenplatten erfordern aufgrund der anspruchsvollen Baustellenlogistik und der besonderen Anforderungen bei der Ausführung der Betonage eine sehr sorgfältige Arbeitsweise bei der Fertigstellung. Im Rahmen dieses Beitrags liegt der Schwerpunkt auf der Ausführung. Es wurde untersucht, wie die Schubkraftübertragung durch ungewollte Betonierfugen herabgesetzt und das Verbundverhalten infolge unzureichender Nachverdichtung beeinflusst werden können.Concrete technological features in executing massive floor platesDue to the demanding site logistics and special requirements during the casting the manufacturing of massive floor plates must be executed very carefully. Therefore this article is focussed on the execution. In this context it was investigated how the shear force transmission is reduced by construction joints and the bonding behavior is influenced by an insufficient final compaction of the top layer.
A Prototypical Small‐Molecule Modulator Uncouples Mitochondria in Response to Endogenous Hydrogen Peroxide Production
Authors: McQuaker Stephen J. , Quinlan Casey L. , Caldwell Stuart T. , Brand Martin D. , Hartley Richard C. 
Published: May 2013

AbstractA high membrane potential across the mitochondrial inner membrane leads to the production of the reactive oxygen species (ROS) implicated in aging and age‐related diseases. A prototypical drug for the correction of this type of mitochondrial dysfunction is presented. MitoDNP‐SUM accumulates in mitochondria in response to the membrane potential due to its mitochondria‐targeting alkyltriphenylphosphonium (TPP) cation and is uncaged by endogenous hydrogen peroxide to release the mitochondrial uncoupler, 2,4‐dinitrophenol (DNP). DNP is known to reduce the high membrane potential responsible for the production of ROS. The approach potentially represents a general method for the delivery of drugs to the mitochondrial matrix through mitochondria targeting and H2O2‐induced uncaging.
ChemInform Abstract: Quaternary Arsenides AM1.5Tt0.5As2 (A: Na, K, Rb; M: Zn, Cd; Tt: Si, Ge, Sn): Size Effects in CaAl2Si2‐ and ThCr2Si2‐Type Structures.
Authors: Khatun Mansura , Stoyko Stanislav S. , Mar Arthur 
Published: May 2013

AbstractTen quaternary arsenides of title are prepared by reaction of stoichiometric mixtures of the elements (alumina crucible, 600—650 °C, 10 d).
ChemInform Abstract: Luminescence and Energy Transfer Properties of Ca2Ba3(PO4)3Cl and Ca2Ba3(PO4)3Cl:A (A: Eu2+/Ce3+/Dy3+/Tb3+) under UV and Low‐Voltage Electron Beam Excitation.
Authors: Shang Mengmeng , Geng Dongling , Yang Dongmei , Kang Xiaojiao , Zhang Yang , Lin Jun 
Published: May 2013

AbstractPure Ca2Ba3(PO4)3Cl (CBP) and rare earth (Eu2+/Ce3+/Dy3+/Tb3+)‐doped CBP phosphors are prepared via a Pechini‐type sol‐gel process involving stoichiometric amounts of Ln(NO3)3, CaCl2, BaCl2·2H2O, citric acid, PEG, and (NH4)H2PO4 (gel drying, 1.
ChemInform Abstract: Short‐Range Magnetic Ordering in the Geometrically Frustrated Layered Compound YBaCo4O7 with an Extended Kagome Structure.
Authors: Bera A. K. , Yusuf S. M. , Banerjee S. 
Published: May 2013

AbstractThe title compound is synthesized by solid state reaction of stoichiometric amounts of Y2O3, BaCO3, and Co3O4 (Pt crucible, 1.
ChemInform Abstract: Direct Hydrofluorothermal Synthesis of Sodium Transition Metal Fluorosulfates as Possible Na‐Ion Battery Cathode Materials.
Authors: Wang Qianlong , Madsen Alex , Owen John R. , Weller Mark T. 
Published: May 2013

AbstractThe isomorphous compounds (IIIa—c) crystallize in the orthorhombic space group Pbcn with Z = 4 (single crystal XRD).
ChemInform Abstract: Preparation and Crystal Structure of a New Lithium Vanadium Fluoride Li2VF6 with Trirutile‐Type Structure.
Authors: Nakhal Suliman , Weber Dominik , Lerch Martin 
Published: May 2013

AbstractThe new title compound is obtained together with Li3VF6 from a 2:1 mixture of LiF and VF4 (monel capsule, 500 °C, 12 h).
ChemInform Abstract: Mercury Bismuth Chalcohalides, Hg3Q2Bi2Cl8 (Q: S, Se, Te): Syntheses, Crystal Structures, Band Structures, and Optical Properties.
Authors: Wibowo Arief C. , Malliakas Christos D. , Chung Duck Young , Im Jino , Freeman Arthur J. , Kanatzidis Mercouri G. 
Published: May 2013

AbstractIn the frame of a search for potential candidates of X‐ray and γ‐ray semiconductor detectors, the quaternary chalcohalides Hg3Q2Bi2Cl8 (Q: S (I), Te (II), Se (III)) are quantitatively obtained by solid state reaction of stoichiometric mixtures of HgQ, HgCl2, and BiCl3 (evacuated silica tube, (I) 300 °C, 1.5 d, (II) 200 °C, 2 d, (III) 600 °C, 2 d) avoiding their tendency for phase separation.
ChemInform Abstract: Asymmetric Henry Reactions Catalyzed by Metal Complexes of Chiral Oxazoline Based Ligands.
Authors: Aydin A. Ebru , Yuksekdanaci Seda 
Published: May 2013

AbstractA series of novel chiral ligands derived from pyrrolecarbonitrile, salicyclic acid, and norephedrine are synthesized and applied as catalysts in the enantioselective Henry reaction.
ChemInform Abstract: Three‐Carbon Homologation of Diorganozincs with Lithiated Acetylenic Epoxides.
Authors: Denichoux Aurelien , Debien Laurent , Cyklinsky Mathieu , Kaci Malika , Chemla Fabrice , Ferreira Franck , Perez‐Luna Alejandro 
Published: May 2013

AbstractTitle reaction gives zincates that undergo a 1,2‐metallate rearrangement along with the transfer of an alkyl or a silyl group affording allenylzinc intermediates.
ChemInform Abstract: Photochemically Induced Radical Alkynylation of C(sp3)—H Bonds.
Authors: Hoshikawa Tamaki , Kamijo Shin , Inoue Masayuki 
Published: May 2013

Abstract1‐Tosyl‐2‐(trimethylsilyl)acetylene (I) is an efficient reagent for the direct photochemical alkenylation of different substrates, e.g. alkanes, alcohols, amines, and cyclic amides.
ChemInform Abstract: Supported Ionic‐Liquid Layer on Polystyrene—TEMPO Resin: A Highly Efficient Catalyst for Selective Oxidation of Activated Alcohols with Molecular Oxygen.
Authors: Liu Lin , Liu Dong , Xia Zhiwei , Gao Jiulin , Zhang Tianlin , Ma Juanjuan , Zhang Dongen , Tong Zhiwei 
Published: May 2013

AbstractA new catalyst consisting of CuCl2 and an ionic‐liquid layer supported on polystyrene—TEMPO resin is shown to be an efficient catalyst for the oxidation of primary alcohols to the corresponding aldehydes.
ChemInform Abstract: Carboxy‐Directed Asymmetric Hydrogenation of 1,1‐Diarylethenes and 1,1‐Dialkylethenes.
Authors: Song Song , Zhu Shou‐Fei , Yu Yan‐Bo , Zhou Qi‐Lin 
Published: May 2013

AbstractThe carboxy group in the substrates is crucial for this reaction as it acts as an anchor for the Ir‐catalysts.
ChemInform Abstract: HAP‐Pd(0): A Highly Efficient Recyclable Heterogeneous Catalyst for the Selective Reduction of Carbon—Carbon Double Bond in α,β‐Unsaturated Ketones.
Authors: Chambyal Omkar Singh , Paul Satya , Shamim Tahira , Gupta Monika , Gupta Rajive , Loupy Andre 
Published: May 2013

AbstractThe employed catalyst, palladium hydroxyapatite, can be recovered by simple filtration and reused for five consecutive runs without significant loss of activity.
ChemInform Abstract: Mono and Difluorination of Centers α to Sulfonates and Phosphonates Using AcOF.
Authors: Vints Inna , Gatenyo Julia , Rozen Shlomo 
Published: May 2013

AbstractA general method for the selective introduction of one or two fluorine atoms in α‐position to a sulfonate or phosphonate moiety in very short time is described.
ChemInform Abstract: A General and Efficient Method for Synthesis of Enaminones and Enamino Esters Catalyzed by NbCl5 under Solvent‐Free Conditions.
Authors: Liu Yu‐Heng , Wang Ping , Cheng Gui‐Tian 
Published: May 2013

AbstractNbCl5 catalyzes the synthesis of enaminones and enamino esters from the corresponding 1,3‐dicarbonyl compounds and primary amines under solvent‐free conditions.
ChemInform Abstract: Catalytic Hydrogenation of Cyclic Carbonates: A Practical Approach from CO2 and Epoxides to Methanol and Diols.
Authors: Han Zhaobin , Rong Liangce , Wu Jiang , Zhang Lei , Wang Zheng , Ding Kuiling 
Published: May 2013

AbstractThe title highly efficient synthesis proceeds under relatively mild conditions and provides a potential process for the use of recovered waste polycarbonate as a resource.
ChemInform Abstract: Bifunctional Tertiary Phosphine Catalyzed Cascade Michael—Henry Reaction of a β‐Nitroolefin and a 2‐(1‐Substituted 3‐oxo‐3‐phenylpropyl)malononitrile.
Authors: Wang Ying , Yuan Wei , Zheng Hu‐Fei , Shi De‐Qing 
Published: May 2013

AbstractBOL is used as an efficient catalyst in the diastereoselective synthesis of highly functionalized cyclohexanols.
ChemInform Abstract: Poly(4‐vinylpyridinium bromochromate): An Efficient Reagent for Bromination of Aromatic Compounds.
Authors: Albadi Jalal , Tajik Hassan , Keshavarz Mosadegh , Abedini Masoumeh 
Published: May 2013

AbstractPoly(4‐vinylpyridinium bromochromate) is shown to be an efficient reagent for the bromination of aromatic compounds.
ChemInform Abstract: Diastereoselective Three‐Component Mannich Reaction Catalyzed by Silica‐Supported Ferric Hydrogensulfate.
Authors: Eshghi Hossein , Rahimizadeh Mohammad , Hosseini Mohsen , Javadian‐Saraf Aida 
Published: May 2013

AbstractOptimum reaction conditions are examined for the diastereoselective three‐component Mannich reaction catalyzed by silica‐supported ferric hydrogensulfate.
ChemInform Abstract: Stereoselective Synthesis of 1,3‐anti Diols by an Ipc‐Mediated Domino Aldol‐Coupling/Reduction Sequence.
Authors: Dieckmann Michael , Menche Dirk 
Published: May 2013

AbstractDiols and intermediate boronates are obtained as inseparable mixtures of anti/anti diastereomers whereas excellent anti/syn diastereoselectivity is observed.
ChemInform Abstract: Pd‐Catalyzed C—H Oxygenation with TFA/TFAA: Expedient Access to Oxygen‐Containing Heterocycles and Late‐Stage Drug Modification.
Authors: Shan Gang , Yang Xinglin , Ma Linlin , Rao Yu 
Published: May 2013

AbstractExcellent reactivity, ortho‐selectivity, good functional group tolerance, and high yields are demonstrated for the title reaction.
ChemInform Abstract: Facile Microwave‐Assisted Michael Addition of Diphenacyl Sulfides to Chalcones under Solvent‐Free Conditions: Generation of Symmetrical and Unsymmetrical 1,5‐Diketones.
Authors: Paul Nidhin , Shanmugam Muniyappapillai Jeganathan , Muthusubramanian Shanmugam 
Published: May 2013

AbstractOptimum reaction conditions are examined for the addition of diphenacyl sulfides (I) to substituted chalcones (II) to give 1,5‐diketones (III).
ChemInform Abstract: Cyanative Self‐Condensation of Aromatic Aldehydes Promoted by VO(OiPr)3—Lewis Base as a Cooperative Catalyst.
Authors: Kodama Koichi , Kawamata Hiroaki , Takahashi Naoya , Hirose Takuji 
Published: May 2013

AbstractIt is crucial that the reaction is carried out in oxygen atmosphere to afford the products selectively.