bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cornification (Keratinization) in Basal Cell Carcinoma: A Histopathological and Immunohistochemical Study of 16 Cases
Authors: Misago Noriyuki , Satoh Toshimi , Narisawa Yutaka 
Published: July 2014

AbstractThe concept of keratotic BCC is obscure and not well‐defined. To elucidate the histopathological and immunohistochemical properties of cornification in BCC and to clarify the concept of keratotic BCC, by careful examination of 600 BCC specimens, we selected 16 cases of BCC that showed cornification. We investigated the precise histopathological features of these 16 cases, and studied the immunohistochemical expression patterns of anticytokeratin (CK) antibodies (CKs 1, 10, 13, 14, 17) and other antibodies in these cornifying (keratotic) BCCs. We compared these data to those from normal adult hair follicles and three types of cornifying cysts (epidermal cyst, tricholemmal cyst and steatocystoma). Six types of cornification were observed in these BCCs; 1) infundibular type (4 cases) with thin laminated corneocytes expressing CKs 1 and 10, 2) tricholemmal (isthmus) type (9 cases) showing compact, homogenous cornified contents with CK 17 expression on the surrounding cells, 3) inner root sheath type (1 case) characterized by compact, blue‐gray corneocytes lined by CK 13 positive‐squamous cells with red trichohyalin granules, 4) sebaceous duct type (1 case) characterized by crenulated cornified cells expressing CK 17, 5) apocrine acrosyringium type (2 cases) characterized by small duct‐like structures lined by eosinophilic cuticle expressing CEA, in association with keratohyaline granules, and 6) cornifying microcyst type (10 cases) characterized by micro and small cystic structures containing the debris of cornified cells, which was associated with the infundibular or tricholemmal type and could be classified as having the primitive features of the tricholemmal type of cornification. The tricholemmal type could be subdivided into two groups: one with keratohyaline granules and the other without keratohyaline granules, and the cornified contents in approximately 30% of the cornified areas in this type were positive for CK 17. The matrical type of cornification (seventh type) was not seen in our study. The examples described as “keratotic BCC” thus far were similar to BCCs with cornification of the tricholemmal (isthmus) or infundibular type. The cornification in BCCs could be classified into seven types. Excluding the cornifying microcyst type, the tricholemmal type is the most common type of cornification. This type will be abnormal and incomplete in attempts to cornify in the form of an isthmus, occasionally with concomitant exhibition of lower infundibular differentiation. The keratotic BCC is considered to be BCC with cornification of the tricholemmal (isthmus) or infundibular type.
Microscopic Polyangiitis Presenting Urticarial Erythema and Henoch‐Schönlein Purpura: Two Case Reports
Authors: Maejima Hideki , Shirai Kyoumi , Shimamura Yumi , Harada Harumi , Eto Hikaru 
Published: July 2014

AbstractMicroscopic polyangiitis (MPA) is well known as a life‐threatening member of a group of systemic vasculitis diseases. We report two cases of MPA. Case 1 was a 79‐year‐old‐man who had been diagnosed with anti‐neutrophil‐cytoplasmic‐antibody associated vasculitis (ANCA associated vasculitis) with alveolar hemorrhage and crescentric glomerulonephritis (CrGN). He presented with urticarial erythema in the abdomen, legs and back. The skin biopsy specimens showed leukocytoclastic vasculitis on the upper dermis. Case 2 was a 74‐year‐old‐man, who presented with purpura on the abdomen, buttocks and legs that were similar to Henoch‐Schönlein purpura (HSP). He also suffered from interstinal pneumonia. His renal biopsy specimens showed glomerulosclerosis and the peripheral pattern anti‐neutrophil cytoplasmic antibody (P‐ANCA) was positive. We reviewed the skin eruptions that had been reported with MPA, including our cases.
Benign Cutanous Degos' Disease: A Case Report and Review of the Literature
Authors: Coskun Basak , Sarai Yunus , Cicek Demet , Ozercan Resat 
Published: July 2014

AbstractWe report a case of benign form of Degos' disease, a rare condition often characterized by multisystemic vasculopathy, and discuss the case by the light of the limited literature available. A 34‐year‐old male patient was admitted to our clinic with lesions on his neck and back and a history of not getting any benefit from previous acne medications. Dermatological examination revealed erythematous papules with hemorrhagic crusts on their surfaces and many well‐defined atrophic scar tissues. Histopathological evaluation of a biopsy obtained from a lesion revealed the findings of Degos' disease. Further evaluation did not reveal any sign of systemic involvement. He was diagnosed with the benign form of Degos' disease.
Mucinous Eccrine Nevus
Authors: Park Hyun Su , Lee Un Ha , Choi Jung Chul , Chun Duk Kyu 
Published: July 2014

AbstractA 46‐year‐old man with an erythematous, tender, swollen patch on the dorsum of his left fourth toe visited us. The biopsied tissue showed a proliferation of normally structured eccrine glands and ducts surrounded with abundant materials confirmed as mucin by toluidine blue stain. Mucinous eccrine nevus is an extremely rare entity, and only two cases have been reported in the literature. We describe a case of mucinous eccrine nevus which was late in onset and presented as a swollen patch.
Genetically Modified Mice as a Tool to Study Inflammatory Skin Diseases
Authors: Haase Ingo , Pasparakis Manolis , Krieg Thomas 
Published: July 2014

AbstractAlthough mice have a long tradition as models for human skin diseases, they have recently received increasingly more attention. This is because of the rapid advancement of genetic engineering methods which made it possible to create mice with precisely defined genetic changes. Many of these mice develop impressive and sometimes unexpected, puzzling phenotypes. Their interpretation is a major challenge to the basic researcher and can often be ameliorated by the input of an experienced dermatologist. Together with recent examples of genetically modified mouse models of inflammatory skin diseases we give a short overview of the methods used to generate such mice, describe possible ways to analyse them, and discuss problems that arise in the interpretation of the findings.
Drug Eruption Caused by Azathioprine: Value of Using the Drug‐Induced Lymphocytes Stimulation Test for Diagnosis
Authors: Mori Hitoshi , Yamanaka Keiichi , Kaketa Masato , Tamada Kyoko , Hakamada Arata , Isoda Ken‐ichi , Yamanishi Kiyofumi , Mizutani Hitoshi 
Published: July 2014

AbstractAzathioprine (AZA) is an immunosuppressant commonly used for organ transplantation and autoimmune diseases. Allergic side effects of AZA are rare, and reported allergic skin eruptions from AZA are very limited in Japan. We report AZA‐induced drug eruption that developed in two cases of systemic scleroderma with polymyositis. One case presented with Stevens‐Johnson syndrome, and the other had systemic papular erythema. The stimulation indices of the drug‐induced lymphocyte stimulation test (DLST) for AZA in these two patients were as high as 2,180% and 430%, respectively, but those of healthy volunteers were under 120% without nonspecific suppression of lymphocyte proliferation. Other drugs used simultaneously were ruled out by patch and challenge tests. The challenge test for Stevens‐Johnson syndrome type drug allergy is very risky. DLST is a good diagnostic tool for AZA allergy, especially for severe drug allergy cases.
Mucinous Nodules on the Skin Overlying a Rheumatoid Arthritic Joint
Authors: Umebayashi Yoshihiro 
Published: July 2014

AbstractA rare case of mucinous nodules on the skin overlying rheumatoid synovitis in a 79‐year‐old man is described. The patient had a five year history of RA. The patient had complained of arthralgia in the left elbow joint, and X‐ray demonstrated narrowing of the joint space along with bone destruction. He underwent an intraarticular injection of dexamethazone and lidocaine. Three weeks later, he noticed two dome‐shaped nodules about 5 mm in size developing on the elbow. Histopathological examination demonstrated poorly defined mucinous nodules in the upper dermis. The mucinous material positively stained with alcian blue and colloid iron, and was metachromatic with toluidine blue. These positive stainings disappeared after hyaluronidase digestion. Five to six weeks after being resected, both nodules recurred. Lesional injections of triamcinolone were effective. The intraarticular injections preceding the appearance of the nodules might have created channels from the joint space to the skin. Leakage of activated synovial cells, which produced hyaluronic acid, through the channels might have caused the mucinous stroma of the nodules.
Drug Eruption Due to Peplomycin: An Unusual Form of Stevens‐Johnson Syndrome with Pustules
Authors: Umebayashi Yoshihiro , Enomoto Hisako , Ogasawara Michio 
Published: July 2014

AbstractA rare case of Stevens‐Johnson syndrome (SJS) due to peplomycin in a 48‐year‐old man is described. The patient had squamous cell carcinoma on the scalp and underwent preoperative neoadjuvant chemotherapy with peplomycin. On the fifth day of the chemotherapy, he developed a fever and multiple dusky violaceous erythematous areas and pustules on his trunk, thighs, and palms. Erosive erythema and erosions also developed on his soles, scrotum, and oral mucosa. A biopsy specimen taken from the eruption on the thigh revealed marked liquefaction degeneration of the basal layer of the epidermis. Laboratory examinations demonstrated aggravation of liver function. Additionally, the patient developed conjunctivitis and corneal erosions. Although he had some subcorneal pustules, we diagnosed the case as an unusual form of SJS because of severe mucous membrane involvement. Oral prednisolone was administered, and the symptoms subsided. Then the patient underwent wide local excision. One month after surgery, we performed patch tests and a lymphocyte stimulation test with negative results. Then we re‐administered peplomycin starting with 1/20 of a daily dose and gradually increasing the dose each day. After administration of the regular daily dose, the patient had a relapse of fever, eruptions, stomatitis, corneal erosions, and liver dysfunction. Therefore, a definite diagnosis of drug eruption due to peplomycin was made.
Behçet's Syndrome with Pyoderma‐Gangrenosum‐Like Lesions Treated Successfully with Dapsone Monotherapy
Authors: Joshi Arun , Mamta  
Published: July 2014

AbstractBehçet's syndrome (BS) is a rare multisystem disorder belonging to a group of neutrophilic dermatoses. We report a 65‐year‐old male patient who had suffered from recurrent painful orogenital ulcers for 50 years from the age of 15 and started developing pustular and bullous lesions evolving into non‐healing ulcers similar to those seen in pyoderma gangrenosum (PG) two months prior to presenting to us. There was no evidence of systemic disease or malignancy. Routine baseline investigations were within normal limits. The patient was treated successfully with dapsone, antibiotics, and local wound care.
Anti‐Ribosomal‐P Antibodies in a Sjögren Syndrome Patient Associated with Lupus Erythematosus
Authors: Muro Yoshinao , Tomita Yasushi 
Published: July 2014

AbstractWe describe a 36‐year‐old woman who had Sjögren syndrome with anti‐ribosomal P antibodies and who developed erythema on her back and arms. The histological specimen showed lymphocytic infiltration around the sweat and salivary glands. Her serum reacted with ribosomal‐P0 protein in immunoblotting with HeLa cell extract and P0 recombinant protein. Although autoantibodies to ribosomal‐P proteins appear mainly in patients with systemic lupus erythematosus (SLE), a diagnosis of SLE in this patient could not be supported.
Multiple Basal Cell Carcinomas Arising in a Port‐Wine Stain with a Remote History of Therapeutic Irradiation
Authors: Kim Byung‐Soo , Lee Jae‐Bong , Jang Ho‐Sun , Kwon Yoo‐Wook , Kwon Kyung‐Sool , Oh Chang‐Keun 
Published: July 2014

AbstractThe coexistence of a basal cell carcinoma and a port‐wine stain is a very rare condition that may be associated with previous treatments. We present a case of multiple basal cell carcinomas developing within the boundaries of a port‐wine stain, which had been treated with a tholium X and argon laser. Our case suggests that port‐wine stains which were previously treated with irradiation or argon laser should be examined carefully and regularly by both physician and patient, because they may hide basal cell carcinomas.
Coexistence of Spindle Cell Lipoma and Ordinary Lipoma
Authors: Sakai Hitomi , Kuroda Kei , Hara Dai , Tajima Shingo 
Published: July 2014

AbstractWe report a patient with a spindle cell lipoma on the nape and three ordinary lipomas on the abdomen and extremities. The coexistence of spindle cell lipoma and ordinary lipoma in a single patient is rare. Abundant CD34‐positive spindle cells and mast cells were found in the spindle cell lipoma, but in the ordinary lipomas, only a small number of CD34‐positive spindle cells were found in the interstitial connective tissue and no mast cells were seen. Because mast cells are known to stimulate mesenchymal cell proliferation and collagen production, mast cell infiltration may be a trigger for the proliferation of CD34‐positive spindle cells, leading to the conversion of ordinary lipoma into spindle cell lipoma.
Bacillary Angiomatosis in an Immunocompetent Child with a Grafted Traumatic Wound
Authors: Turgut Mehmet , Alabaz Derya , Karakaş Mehmet , Kavak Meric , Aksaray Necmi , Alhan Emre , Çevlik Filiz , Tuncer İlhan 
Published: July 2014

AbstractBacillary angiomatosis is an infectious disease which usually develops in immunocompromised patients. Contact with cats is implicated in its pathogenesis. We report a seven‐year‐old immunocompetent boy with bacillary angiomatosis without a history of direct contact with cats. The clinical diagnosis of bacillary angiomatosis was made following histopathological examination of a biopsy sample from the infected facial wound, in the vicinity of which angiomatous lesions had developed. Surprisingly, similar lesions also appeared at the donor site of the skin graft which was grafted on the facial wound. This case demonstrates that bacillary angiomatosis may also be seen in immunocompetent patients and that it may contaminate wounds without the intermediary of cats.
Taste Disorders in Healthy “Carriers” and “Non‐Carriers” of Candida albicans and in Patients with Candidosis of the Tongue
Authors: Sakashita Sayuri , Takayama Kaoru , Nishioka Kiyoshi , Katoh Takuro 
Published: July 2014

AbstractImpairments in taste perception may be caused by a number of factors, including the presence of Candida albicans in the oral cavity. We attempted to establish whether the presence of Candida albicans on the tongue is a cause of taste disorders by studying taste disorders in patients with candidosis of the tongue and in healthy “carriers” and “non‐carriers” of C. albicans. Taste disorders and their severity were objectively assessed by the filter‐paper disk method in 18 patients with candidosis of the tongue and in 33 healthy “carriers” and 167 healthy “non‐carriers” of C. albicans. The gustatory function was re‐tested in 7 patients and 8 “carriers” after treatment with topical anti‐mycotic medication to detect any improvement. Patients with candidosis of the tongue and “carriers” of C. albicans demonstrated significantly higher incidences (p<0.001) of taste disorders than did “non‐carriers”. The mean taste threshold of each of the four individual taste qualities was significantly higher in patients with candidosis than in “non‐carriers”. The average taste threshold was significantly higher in “carriers” than in “non‐carriers”. Post‐treatment improvement or recovery from taste disorders was obtained in 5 out of 7 patients (71.4%) with candidosis and in 7 out of 8 “carriers” (87.5%) of C. albicans. This study clearly demonstrates that not only overt candidosis of the tongue but also commensal harboring of ***C. albicans is a cause of taste disorders.
A Case of Rheumatoid Nodulosis Successfully Treated with Surgery
Authors: Kai Yoshitaka , Anzai Saburo , Shibuya Hiromi , Fujiwara Sakuhei , Takayasu Susumu , Asada Yuji , Terashi Hiroto 
Published: July 2014

AbstractWe report the case of a 76 year‐old male with multiple subcutaneous nodules, but without joint symptoms or deformities, who was diagnosed histopathologically with rheumatoid nodulosis after resection of the nodules. Rheumatoid nodulosis is a disease characterized by multiple subcutaneous nodules that are histopathologically similar to rheumatoid nodules, a high titer of rheumatoid factor, and radiologically detectable cystic bone lesions, but with none or few of the systemic manifestations or joint activity of rheumatoid arthritis (RA). It is considered to be a benign variant of RA. This rare disease must be considered when a case of multiple subcutaneous nodules is encountered, even in aged males without joint symptoms or deformities.
Human Papillomavirus Associated with Bowen's Disease of the Finger
Authors: Sato Tomotaka , Morimoto Arei , Ishida Yasuo , Matsuo Itsuro 
Published: July 2014

AbstractWe report here a case of Bowen's disease that developed in the periungual area of the left ring finger of a 55‐year‐old Japanese male. Because the histology of the lesion mimicked in part the features of a common wart, a PCR‐based analysis of human papillomavirus (HPV) DNA and sequencing of viral DNA of PCR‐amplified fragments were performed. The lesion contained HPV11 and 16 DNA, and HPV was suspected to play a role in the development of the lesion.
Measurement of the Impact of Atopic Dermatitis on Patients' Quality of Life: A Cross‐Sectional and Longitudinal Questionnaire Study Using the Japanese Version of Skindex‐16
Authors: Higaki Yuko , Kawamoto Kyoko , Kamo Toshiko , Ueda Shu , Arikawa Junko , Kawashima Makoto 
Published: July 2014

AbstractThe impact of atopic dermatitis on patients' quality of life was measured using the Japanese version of Skindex‐16 in a cross‐sectional and longitudinal questionnaire study. One hundred sixty‐two adult patients completed Skindex‐16 and were followed‐up with a standard medical therapy. Three to six months after the initial testing, 135 (83.3%) of the patients again completed Skindex‐16 and also answered a general question about whether their skin condition had improved, remained the same, or become worse. The scores of Skindex‐16 of 162 patients with atopic dermatitis were significantly higher than those of patients with isolated lesions, particularly in the Symptoms and Emotions scales. Patients with severe atopic dermatitis showed significantly higher scores in the three scales (Symptoms, Emotions, and Functioning), and there was a significant positive correlation between the severity and the 3‐scale scores. After the follow‐up period, 78 of 135 patients (57.8%) reported that their skin condition had improved. Forty‐six patients (34.1%) reported that their skin condition had remained the same, and 11 (8.1%) became worse. Among the patients who said their dermatitis had improved, the scores of Skindex‐16 significantly decreased. On the other hand, patients who reported their dermatitis worse showed an increase in the scores. These findings suggest that Skindex‐16 responsively measures the disease severity and clinical change in the estimation of the effects of atopic dermatitis on patients' quality of life. This practical and sensitive, skin‐disease specific, quality‐of‐life instrument is valuable for assessing patients' outcomes, especially their response to therapy, and is useful to understanding and improving the quality of life of patients suffering with atopic dermatitis.
Immunohistochemical Differentiation of Extra‐Ocular Sebaceous Carcinoma from Other Skin Cancers
Authors: Ansai Shin‐ichi , Mitsuhashi Yoshihiko , Kondo Shigeo , Manabe Motomu 
Published: July 2014

AbstractWe performed an immunohistochemical study using routinely processed formalin‐fixed and paraffin‐embedded tissue specimens from 26 cases of extra‐ocular sebaceous carcinoma (EOSC) and eight easily available antibodies. They were polyclonal anti‐carcinoembryonic antigen (CEA) antibody monoclonal anti‐CEA antibody anti‐breast carcinoma associated antigen‐225 antibody (CU18), anti‐CA15.3 antibody (CA15.3), anti‐CD15 antibody (CD15), anti‐breast carcinoma associated antigen antibody (B6.2), anti‐gross cystic disease fluid antigen‐15 antibody (GCDFP15) and anti‐Thomsen‐Friedenreich antigen antibody (TEA). Squamous cell carcinoma, porocarcinoma, syringomatous carcinoma, malignant clear cell hidradenoma, apocrine adenocarcinoma, and extramammary Paget's disease with underlying adenocarcinoma were used as controls. EOSC was positive for CU18 and CA15.3 in most cases, and for CD15 in a few cases. Squamous cell carcinoma of the skin was positive for CA15.3 in only one case. Porocarcinoma, syringomatous carcinoma and malignant clear cell hidradenoma were positive for CEA, CU18, CA15.3, and B6.2 in most cases. Apocrine adenocarcinoma and extramammary Paget's disease with underlying adenocarcinoma were positive for CEA, CU18, CD15, GCDFP15, CA15.3, and B6.2 in most cases. TEA was positive not only in EOSC but also in other skin cancers. Immunohistochemical examinations using these seven of eight antibodies except for TEA and routinely processed formalin‐fixed and paraffin‐embedded tissue specimens are beneficial in differentiating EOSC from other skin cancers.
Drug‐Induced Hypersensitivity Syndrome Due to Anticonvulsants in a Two‐Year‐Old Boy
Authors: Criado Paulo Ricardo , Criado Roberta F. J. , Vasconcellos Cidia , Pegas Jose Roberto P. , Cera Patrícia Calil 
Published: July 2014

AbstractDrug‐induced hypersensitivity syndrome (DIHS) usually refers to severe cutaneous drug eruption associated with systemic involvement and potentially fatal outcome. We report a 2‐year‐old Caucasian boy who developed DIHS due to phenytoin and phenobarbital and who showed extensive internal organ involvement. We are alerting that failure to recognize this drug eruption and discontinue the culprit drug may result in increased severity, greater extent of internal organ involvement, and fatal outcome. The recent research about the influence of human herpesvirus 6 co‐infection on the pathogenesis of DIHS is also discussed by the authors in this paper.
A Case of Bullous Sézary Syndrome
Authors: Ono Atsuko , Isomura Iwao , Isogai Zenzo , Shintani Youichi , Suzuki Akiko , Morita Akimichi 
Published: July 2014

AbstractSézary syndrome is an aggressive variant of cutaneous T cell lymphoma with poor prognosis and clinically characterized by erythroderma and Sézary cells in the blood. Here we report a case of bullous Sézary syndrome. A seventy‐year‐old male presented with erythroderma and inguinal lymph node swelling. Histopathological examination showed dermal and epidermal infiltration of atypical lymphocytes and Sézary cells could be detected in peripheral blood samples. He was therefore diagnosed as Sézary syndrome. Four months after the onset, he developed bullae on axillary and inguinal areas, featuring subepidermal blistering with basal cell degeneration and dense infiltration of atypical lymphocytes. Autoimmune bullous diseases were excluded by negative immunofluorescence. Bullous forms of Sézary syndrome are extremely rare although several cases of a bullous variant of mycosis fungoides have been reported.