bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH GOOD CORPORATE GOVERNANCE DAN PROFITABILITAS TERHADAP NILAI PERUSAHAAN INDEKS IDX30
Authors: Wahyuningtiasari Defi , Sulastiningsih Sulastiningsih 
Published: June 2024

Abstract. The goal of this study is to find out how Profitability, Good Corporate Governance (represented by the Board of Commissioners, Board of Directors, and Audit Committee), and as well as profitability affect the value of a company. In this study, the samples were 15 companies from the 2020–2022 time that were listed on the IDX30 Index of the Indonesia Stock Exchange. The samples were chosen on purpose to get 45 data that were then handled using SPSS version 25. Multiple linear regression, the t-test, the F-test, and the coefficient of determination were used to do the study. This study's results show that the Board of Commissioners, the Audit Committee, and Profitability all have a significant effect on Company Value. However, the Board of Directors does not have a significant effect on Company Value. The F-test shows that the Board of Commissioners, the Board of Directors, the Audit Committee, and Profitability all have an effect on the value of the company at the same time. The coefficient of determination (R2) of these four variables is able to explain on Company Value is strongly at 89,60%.
Abstraksi. Tujuan penelitian ini yaitu guna mengetahui pengaruh Good Corporate Governance yang diimplementasikan menggunakan Dewan Komisaris, Dewan Direksi, dan Komite Audit, serta Profitabilitas terhadap Nilai Perusahaan. Sampel penelitian berjumlah 15 perusahaan di Indeks IDX30 BEI periode 2020–2022. Perusahaan-perusahaan ini dipilih menggunakan metode yang disebut purposive sampling, yang menghasilkan 45 data yang diolah menggunakan SPSS versi 25. Pengujian regresi linier berganda, uji t dan uji F digunakan untuk melakukan analisis. Hasil penelitian menunjukkan bahwa hasil uji t Dewan Komisaris, Komite Audit, dan Profitabilitas semuanya mempengaruhi signifikan terhadap Nilai Perusahaan. Namun Dewan Direksi tidak mempengaruhi signifikan terhadap Nilai Perusahaan. Uji F menunjukkan Dewan Komisaris, Direksi, Komite Audit, dan Profitabilitas berpengaruh terhadap Nilai Perusahaan secara simultan. Hasil Koefisien determinasi (R2) keempat variabel tersebut mampu menjelaskan pengaruhnya terhadap Nilai perusahaan dengan sangat kuat sebesar 89,60%.
Microneedle-enhanced drug delivery: fabrication, characterization, and insights into release and permeation of nanocrystalline imiquimod
Authors: Meiser Sophie Luise , Pielenhofer Jonas , Hartmann Ann-Kathrin , Stein Lara , Dettweiler Jule , Grabbe Stephan , Radsak Markus P. , Langguth Peter 
Published: June 2024

Transcutaneous delivery systems bear several advantages over conventional needle-based injections. Considering the low bioavailability and poor water-solubility of imiquimod, a manufacturing process has been developed to incorporate imiquimod as suspended nanocrystals in different formulations. In this study, three formulations - fast-dissolving microneedle arrays that contain nanocrystalline imiquimod in a poly (vinyl)alcohol matrix and two semisolid preparations-were characterized and compared. The results show that microneedle arrays have an advantage over the semisolid preparations regarding in vitro release and permeation characteristics. Microneedle arrays facilitate ex vivo permeation, thus reducing the applied dose by 93% compared to the semisolid formulations. Additionally, the amount of imiquimod permeated after 24 h maintained the same level even when the contact time of the formulation with the skin is less than 1 hour. In conclusion, our results highlight the great potential of advanced microneedle based delivery systems and foster the further evaluation of this approach.
Kidney outcomes with SGLT2is for type 2 diabetes patients: does background treatment with metformin or RASis matter?
Authors: Chong Kah Suan , Chang Yi-Hsin , Lin Meng-Hsuan , Hsu Chien-Ning , Wang Chi-Chuan , Wang Chih-Yuan , Huang Yun-Lin , Lin Fang-Ju , Ou Huang-Tz 
Published: June 2024

IntroductionThere is a lack of real-world evidence regarding the impact of concomitant metformin and renin-angiotensin system inhibitors (RASis) on sodium-glucose cotransporter-2 inhibitor (SGLT2i)-associated kidney outcomes. This study was aimed to investigate whether SGLT2i-associated kidney outcomes were modified by the concomitant use of metformin or RASis in patients with type 2 diabetes.MethodsSGLT2i users were identified from three electronic health record databases during May 2016 and December 2017 and categorized into those with and without concomitant use of metformin or RASis. Propensity score matching was performed to minimize baseline differences between groups. Study outcomes were mean estimated glomerular filtration rate (eGFR) change and time to 30%, 40%, and 50% eGFR reductions. A meta-analysis was performed to combine the estimates across databases.ResultsAfter matching, there were 6,625 and 3,260 SGLT2i users with and without metformin, and 6,654 and 2,746 SGLT2i users with and without RASis, respectively. The eGFR dip was similar in SGLT2i users with and without metformin therapy, but was greater in SGLT2i users with RASis compared to those without RASis. Neither metformin nor RASi use had a significant effect on SGLT2i-associated eGFR reductions, as evidenced by the hazard ratios (95% CIs) of 30% eGFR reductions for SGLT2is with versus without metformin/RASis, namely 1.02 (0.87–1.20)/1.09 (0.92–1.31). Such findings were also observed in the outcomes of 40% and 50% eGFR reductions.ConclusionUsing metformin or RASis did not modify SGLT2i-associated kidney outcomes in type 2 diabetes.
Should we routinely assess hypothalamic–pituitary–adrenal axis in pediatric patients with Prader–Willi syndrome?
Authors: Wędrychowicz Anna Maria , Doleżal-Ołtarzewska Katarzyna , Zygmunt-Górska Agata , Kalicka-Kasperczyk Anna Urszula , Tyrawa Katarzyna , Wojcik Malgorzata , Janus Dominika , Kot Adrianna , Lecka-Ambroziak Agnieszka , Petriczko Elzbieta , Wielopolska Joanna , Starzyk Jerzy 
Published: June 2024

BackgroundIt has been reported that central adrenal insufficiency (CAI) in pediatric patients (pts) with Prader–Willi syndrome (PWS) may be a potential cause of their sudden death. In addition, the risk of CAI may increase during treatment with recombinant human growth hormone (rhGH).ObjectiveTo prevent both over- and undertreatment with hydrocortisone, we evaluated the prevalence of CAI in a large multicenter cohort of pediatric pts with PWS analyzing adrenal response in the low-dose ACTH test (LDAT) and/or the glucagon stimulation test (GST) and reviewing the literature.MethodsA total of 46 pts with PWS were enrolled to the study, including 34 treated with rhGH with a median dose of 0.21 mg/kg/week. LDAT was performed in 46 pts, and GST was carried out in 13 pts. Both tests were conducted in 11 pts. The tests began at 8:00 a.m. Hormones were measured by radioimmunoassays. Serum cortisol response &gt;181.2 ng/mL (500 nmol/L) in LDAT and &gt;199.3 ng/mL (550 nmol/L) in GST was considered a normal response. Additionally, cortisol response delta (the difference between baseline and baseline) &gt;90 ng/mL and doubling/tripling of baseline cortisol were considered indicators of normal adrenal reserve.ResultsThree GSTs were not diagnostic (no hypoglycemia obtained). LDAT results suggested CAI in four pts, but in two out of four pts, and CAI was excluded in GST. GST results suggested CAI in only one patient, but it was excluded in LDAT. Therefore, CAI was diagnosed in 2/46 pts (4.3%), 1 treated and 1 untreated with rhGH, with the highest cortisol values of 162 and 175 ng/dL, but only in one test. However, in one of them, the cortisol delta response was &gt;90 ng/mL and peak cortisol was more than tripled from baseline. Finally, CAI was diagnosed in one patient treated with rhGH (2.2%).ConclusionWe present low prevalence of CAI in pediatric pts with PWS according to the latest literature. Therefore, we do not recommend to routinely screen the function of the hypothalamic–pituitary–adrenal axis (HPAA) in all pts with PWS, both treated and untreated with rhGH. According to a review of the literature, signs and symptoms or low morning ACTH levels suggestive of CAI require urgent and appropriate diagnosis of HPAA by stimulation test. Our data indicate that the diagnosis of CAI should be confirmed by at least two tests to prevent overtreatment with hydrocortisone.
Estimating and mapping the soil total nitrogen contents in black soil region using hyperspectral images towards environmental heterogeneity
Authors: Lin Nan , Mei Xianjun , Li Jia , Jiang Ranzhe , Wu Menghong , Zhang Wenchun 
Published: June 2024

Introduction: Fast and accurate estimation and spatial mapping of soil total nitrogen (TN) content is important for the development of modern precision agriculture, such as soil fertility monitoring and land reclamation decision-making. Hyperspectral remote sensing has been demonstrated to be an accurate real-time technique for rapid estimation and mapping of soil TN content.Methods: To solve the problem of poor accuracy and generalization of estimation models caused by soil environmental heterogeneity in estimating and mapping soil TN content using hyperspectral images, 502 soil samples were collected from a typical black soil area in Yushu City, Jilin Province, China, as a test area, and three sample grouping strategies were established by soil environmental variables (soil type, thickness of the black soil layer, and topographic factors), and Pearson correlation coefficient and competitive adaptive reweighted sampling algorithm were used to determine the TN characteristic bands of each sample set under different strategies. Based on the data characteristics of the sub-sample set, the local regression estimation model based on sample grouping was constructed using the CatBoost algorithm, and the estimation and distribution mapping of soil TN content was carried out.Results and Discussion: The results showed that after dividing the samples according to the differences in soil environmental factors, the characteristic information of the samples is more targeted, with more abundant numbers and distribution ranges of TN characteristic bands. Compared to the global regression estimation with all samples, the local regression based on the grouping of soil environment differences showed improved accuracy, with the local regression estimation model constructed with the ST-G strategy exhibiting the highest estimation accuracy (Rp2 = 0.839). The results can provide a reference for large-area soil properties mapping, and technical support for soil quality digitization and precision fertilization.
The effect of previous SARS-CoV-2 infection on systemic immune responses in individuals with tuberculosis
Authors: Xavier Mariana S. , Araujo-Pereira Mariana , de Oliveira Quezia M. , Sant’Anna Flavia M. , Ridolfi Felipe M. , de Andrade Alice M. S. , Figueiredo Marina C. , Sterling Timothy R. , Gordhan Bhavna G. , Kana Bavesh D. , Andrade Bruno B. , Rolla Valeria C. , Gomes-Silva Adriano 
Published: June 2024

BackgroundThe impact of previous SARS-CoV-2 infection on the systemic immune response during tuberculosis (TB) disease has not been explored.MethodsAn observational, cross-sectional cohort was established to evaluate the systemic immune response in persons with pulmonary tuberculosis with or without previous SARS-CoV-2 infection. Those participants were recruited in an outpatient referral clinic in Rio de Janeiro, Brazil. TB was defined as a positive Xpert-MTB/RIF Ultra and/or a positive culture of Mycobacterium tuberculosis from sputum. Stored plasma was used to perform specific serology to identify previous SARS-CoV-2 infection (TB/Prex-SCoV-2 group) and confirm the non- infection of the tuberculosis group (TB group). Plasmatic cytokine/chemokine/growth factor profiling was performed using Luminex technology. Tuberculosis severity was assessed by clinical and laboratory parameters. Participants from TB group (4.55%) and TB/Prex-SCoV-2 (0.00%) received the complete COVID-19 vaccination.ResultsAmong 35 participants with pulmonary TB, 22 were classified as TB/Prex-SCoV-2. The parameters associated with TB severity, together with hematologic and biochemical data were similar between the TB and TB/Prex-SCoV-2 groups. Among the signs and symptoms, fever and dyspnea were significantly more frequent in the TB group than the TB/Prex-SCoV-2 group (p &lt; 0,05). A signature based on lower amount of plasma EGF, G-CSF, GM-CSF, IFN-α2, IL-12(p70), IL-13, IL-15, IL-17, IL-1β, IL-5, IL-7, and TNF-β was observed in the TB/Prex-SCoV-2 group. In contrast, MIP-1β was significantly higher in the TB/Prex-SCoV-2 group than the TB group.ConclusionTB patients previously infected with SARS-CoV-2 had an immunomodulation that was associated with lower plasma concentrations of soluble factors associated with systemic inflammation. This signature was associated with a lower frequency of symptoms such as fever and dyspnea but did not reflect significant differences in TB severity parameters observed at baseline.
Factors influencing early recurrence of atrial fibrillation among elderly patients following radiofrequency catheter ablation and the impact of different antiarrhythmic regimens
Authors: Fei Changdong , Zhao Caitong , Ma Yan , Liu Yupeng , Chen Renzheng , Zhang Hualin 
Published: June 2024

BackgroundPatients with atrial fibrillation (AF) who undergo radiofrequency catheter ablation (RFCA) necessitate the administration of antiarrhythmic drugs to prevent early recurrence. The clinical outcomes among these patients may be influenced by varying antiarrhythmic regimens.ObjectivesTo identify the risk factors associated with early recurrence and compare the clinical outcomes among different antiarrhythmic regimens in elderly patients with AF following radiofrequency catheter ablation (RFCA) during a 3-month period.MethodsA retrospective observational study encompassed 420 elderly patients with AF following RFCA. Baseline data were collected during the initial postoperative visit and clinical outcomes were carefully monitored over a 3-month follow-up period. Logistic regression and Cox-proportional hazard regression analyses were performed to investigate the relationship between various antiarrhythmic regimens and the clinical outcomes.ResultsMultivariate logistic regression analysis revealed that age (p = 0.001), left atrial diameter (p &lt; 0.001), left ventricular diameter (p = 0.015), reactive hyperemia index (RHI) (p &lt; 0.001), antiarrhythmic drug (p &lt; 0.001) and hs-cTnI (p = 0.017) were independent risk factors of early recurrence. Furthermore, in cox survival regression analysis model, survival rate of early recurrence in the amiodarone group was higher than in the propafenone group (HR 2.30, 95%CI 1.17–4.53, p = 0.016) and in the sotalol group (HR 3.60, 95%CI 2.17–5.95, p &lt; 0.001). Compared to the amiodarone group, the incidence of liver dysfunction was lower in the dronedarone group (p = 0.046) and the propafenone group (p = 0.021). The incidence of bradyarrhythmia (p = 0.003), QT interval prolongation (p = 0.035) and atrioventricular transmission block (p = 0.021) were higher in the sotalol group than in the amiodarone group.ConclusionRHI was identified as an independent risk factor for early recurrence among elderly AF patients after RFCA. Compared to amiodarone, propafenone and sotalol exhibited an elevated risk of early recurrence. Although there was no significant difference in early recurrence between amiodarone and dronedarone, dronedarone emerged as the preferred option due to its lower frequency of adverse drug reactions than amiodarone.
Histoplasmosis in patients living with HIV in Europe: review of literature
Authors: Kontogiannis Dimitra , Di Lorenzo Andrea , Zaçe Drieda , Benvenuto Domenico , Moccione Martina , Muratore Gianmarco , Giacalone Maria L. , Montagnari Giulia , Carnevale Laura , Mulas Tiziana , Coppola Luigi , Campogiani Laura , Sarmati Loredana , Iannetta Marco 
Published: June 2024

Histoplasma capsulatum (var. capsulatum Hcc and duboisii Hcd), is a dimorphic fungus that causes histoplasmosis. It usually affects people coming from endemic areas, causing a variety of clinical manifestations up to progressive disseminated histoplasmosis (PDH), especially among people living with HIV (PLWH). We conducted a systematic review to assess histoplasmosis burden of PLWH in Europe. The review follows PRISMA guidelines, with protocol registered in PROSPERO (CRD42023429779). Seventy-eight articles were selected, including 109 patients (32 women). On overall, median age was 37 years. Forty-six patients were Americans, 39 Africans, 17 Europeans, 5 Asians, in 2 cases nationality was not specified. Cases were mainly diagnosed in Italy (28.4%), France (17.3%) and Spain (17.4%), with a north–south gradient. Six cases lacked epidemiologic links with endemic areas. Concerning CDC HIV staging at diagnosis, the information was available for 60 PLWH (55%) and all subjects were at stage C3 except for two subjects at stage B3. PDH was the AIDS-presenting illness in 39 patients. Most patients had a PDH (80.7%); other common extrapulmonary forms were isolated cutaneous histoplasmosis (7.3%), or lymphatic localization (2.7%). In 30 cases, the diagnosis was made by analyzing only one sample. For the remaining 79 cases, multiple samples were collected from each patient. Regarding the biological sample more frequently used for the diagnosis of histoplasmosis, bronchoalveolar lavage sample was taken from 39 patients, and tested positive in 51.3% of cases; 36 patients underwent a skin biopsy which was positive in 86.1% of cases and 28 patients performed bone-marrow biopsy, which led to the diagnosis of histoplasmosis in 92.9% of cases. The identification of Histoplasma capsulatum was available in 97 PLWH through examination of different samples: Hcc and Hcd were identified in 89 and 8 PLWH, respectively. Concerning therapies, 67.9% were treated with liposomal amphotericin B, 18.3% with itraconazole, 10 died pre-treatment. The overall mortality rate was 23.6%. Non-survivors exhibited more frequently gastrointestinal symptoms (p = 0.017), while cutaneous signs correlated with better survival (p = 0.05). Untreated patients faced higher mortality (p &lt; 0.001). Histoplasmosis should be considered amongst opportunistic infection in PLWH, even in Europe, especially if patients originate from or have travelled to endemic areas.Systematic review registration: The registration number is CRD42023429779.
Exploring the neural and behavioral correlates of cognitive telerehabilitation in mild cognitive impairment with three distinct approaches
Authors: Caminiti Silvia Paola , Bernini Sara , Bottiroli Sara , Mitolo Micaela , Manca Riccardo , Grillo Valentina , Avenali Micol , De Icco Roberto , Capellari Sabina , Carlesimo Giovanni Augusto , Venneri Annalena , Tassorelli Cristina 
Published: June 2024

BackgroundCurrently, the impact of drug therapies on neurodegenerative conditions is limited. Therefore, there is a strong clinical interest in non-pharmacological interventions aimed at preserving functionality, delaying disease progression, reducing disability, and improving quality of life for both patients and their caregivers. This longitudinal multicenter Randomized Controlled Trial (RCT) applies three innovative cognitive telerehabilitation (TR) methods to evaluate their impact on brain functional connectivity reconfigurations and on the overall level of cognitive and everyday functions.MethodsWe will include 110 participants with mild cognitive impairment (MCI). Fifty-five participants will be randomly assigned to the intervention group who will receive cognitive TR via three approaches, namely: (a) Network-based Cognitive Training (NBCT), (b) Home-based Cognitive Rehabilitation (HomeCoRe), or (c) Semantic Memory Rehabilitation Training (SMRT). The control group (n = 55) will receive an unstructured home-based cognitive stimulation. The rehabilitative program will last either 4 (NBTC) or 6 weeks (HomeCoRe and SMRT), and the control condition will be adapted to each TR intervention. The effects of TR will be tested in terms of Δ connectivity change, obtained from high-density electroencephalogram (HD-EEG) or functional magnetic resonance imaging at rest (rs-fMRI), acquired before (T0) and after (T1) the intervention. All participants will undergo a comprehensive neuropsychological assessment at four time-points: baseline (T0), within 2 weeks (T1), and after 6 (T2) and 12 months (T3) from the end of TR.DiscussionThe results of this RCT will identify a potential association between improvement in performance induced by individual cognitive TR approaches and modulation of resting-state brain connectivity. The knowledge gained with this study might foster the development of novel TR approaches underpinned by established neural mechanisms to be validated and implemented in clinical practice.Clinical trial registration: [https://classic.clinicaltrials.gov/ct2/show/NCT06278818], identifier [NCT06278818].
The effects of reward and punishment on the performance of ping-pong ball bouncing
Authors: Yin Cong , Wang Yaoxu , Li Biao , Gao Tian 
Published: June 2024

IntroductionReward and punishment modulate behavior. In real-world motor skill learning, reward and punishment have been found to have dissociable effects on optimizing motor skill learning, but the scientific basis for these effects is largely unknown.MethodsIn the present study, we investigated the effects of reward and punishment on the performance of real-world motor skill learning. Specifically, three groups of participants were trained and tested on a ping-pong ball bouncing task for three consecutive days. The training and testing sessions were identical across the three days: participants were trained with their right (dominant) hand each day under conditions of either reward, punishment, or a neutral control condition (neither). Before and after the training session, all participants were tested with their right and left hands without any feedback.ResultsWe found that punishment promoted early learning, while reward promoted late learning. Reward facilitated short-term memory, while punishment impaired long-term memory. Both reward and punishment interfered with long-term memory gains. Interestingly, the effects of reward and punishment transferred to the left hand.DiscussionThe results show that reward and punishment have different effects on real-world motor skill learning. The effects change with training and transfer readily to novel contexts. The results suggest that reward and punishment may act on different learning processes and engage different neural mechanisms during real-world motor skill learning. In addition, high-level metacognitive processes may be enabled by the additional reinforcement feedback during real-world motor skill learning. Our findings provide new insights into the mechanisms underlying motor learning, and may have important implications for practical applications such as sports training and motor rehabilitation.