bluuebunny/crossref_metadata_2025_split huggingface dataset:
HGF, HNRPD, and sFLT1 Interfere with the Induction of VEGF in Patients with Severe Psoriasis
Authors: Sobolev Vladimir , Muminova Madina , Zhukova Olga , Denisova Elena , Soboleva Anna , Potekaev Nikolay , Korsunskaya Irina , Mezentsev Alexandre 
Published: June 2024

Background:
Restructuring of dermal microcapillaries is one of the
hallmarks of plaque psoriasis. To control the proliferation of vascular endothelial cells,
vascular endothelial growth factor (VEGF) promotes the remodeling of the existing
blood vessels and angiogenesis.

Objective:
This study aimed to explain the lowering protein and mRNA levels of VEGF
in lesional skin of patients with severe psoriasis (the Psoriasis Area and Severity
Index, PASI > 25).

Methods:
Using the method of qPCR, we assessed the expression of VEGF mRNA in
lesional and nonlesional psoriatic skin. Using ELISA, we also compared the levels of
VEGF in skin homogenates of psoriasis patients and healthy volunteers.

Results:
We found that the exacerbation of psoriasis induced VEGF on mRNA and
protein levels 12 and 20 times, respectively. We also confirmed a strong correlation
between VEGF and PASI score in patients with PASI < 25. In addition, we showed that
several factors, namely HGF, HNRPD, and sFLT1 interfere with the biosynthesis of
VEGF in skin lesions of patients with PASI > 25%.

Conclusion:
Thus, using VEGF as a biomarker to monitor the disease shall be done
cautiously in patients with severe psoriasis.
Insights into Co-Expression Network Analysis of MicroProteins and their Target Transcription Factors in Plant Embryo Development
Authors: Shokri Khadijeh , Farrokhi Naser , Ahmadikhah Asadollah , Safaeizade Mahdi , Mousavi Amir 
Published: June 2024

Background:
Gene expression is regulated in a spatiotemporal manner, and the roles of
microProteins (MiPs) in this concept have started to become clear in plants.

Methods:
Here, a microarray data analysis was carried out to decipher the spatiotemporal role of
MiPs in embryo development. The guilt-by-association method was used to determine the corresponding
regulatory factors.

Results:
Module network analyses and protein-protein interaction (PPI) assays suggested 13 modules
for embryo development in the Arabidopsis model plant. Various biological processes such as
metabolite biosynthesis, hormone transition and regulation, fatty acid and storage protein biosynthesis,
and photosynthesis-related processes were prevalent. Different transcription factors (TFs) at different
stages of embryo development were found and reviewed. Furthermore, 106 putative MiPs
were identified that might be involved in the regulation of embryo development. Candidate hub
MiPs (15) at embryo developmental stages were identified by PPI network analysis and their putative
regulatory roles were discussed. Previously reported MiPs, AT1G14760 (KNOX), AT5G39860
(PRE1), and AT2G46410 (CPC), were noted to be present in modules M3 and M8.

Conclusion:
Molecular comprehension of regulatory factors including MiPs and TFs during embryo
development allows targeted breeding of the corresponding traits and genome-based engineering of
value-added new varieties.
Zirconia Cementation: A Systematic Review of the Most Currently Used Protocols
Authors: Batista Adriana , Palacios Nayeli , Ricardo Alvarado Jiménez Omar 
Published: June 2024

Objective
A systematic review of the existing literature was conducted and in vitro studies from 2019 to 2023 were analyzed on Zirconia's most resistant cementation protocol.

Methods
A systematic review of studies on the bond strength between zirconia and resin cement was carried out using different surface treatment protocols. The search was performed in two electronic databases, PubMed and Cochrane.

Results
Electronic searches yielded 1225 non-duplicated articles (Fig. 1), of which 388 were chosen after screening the titles and abstracts. After examining the full texts of these articles, a further 340 were excluded. There remained 48 studies to which the selection by inclusion and exclusion criteria was applied, eliminating 31 articles, of which 17 were finally included for the qualitative study.

Conclusion
Under the limitations of the present systematic review, it can be concluded that treating Zirconia with a combination of surface modifying agents, both mechanical and chemical, substantially improves its adhesive ability with resin cement. Aluminum oxide sandblasting, hydrofluoric acid etching, tribochemical silica coating, laser, and etching with a combination of acids in the Zircos E system are micromechanical treatments that improve the bond strength between zirconia and resin cements. MDP silane agent is an effective chemical treatment to improve the bond strength between zirconia and resin cements. Coating exclusively with a silica layer does not improve the bond strength between zirconia and resin cement.
Research on Optimization of Nonlinear Extended State Observer for the
Upper-Limb Rehabilitation Robot Controller
Authors: Zhang Peng , Liu Luyu , Nan FangHao , Wang Peng 
Published: June 2024

Background:
In recent years, patents have shown that upper-limb rehabilitation robots
play a significant role in home-based rehabilitation training for stroke hemiplegia patients. Changes
in muscle tension during the flaccid paralysis phase cause the rehabilitation robot to deviate from
the predetermined motion trajectory. This poses a challenge to the mathematical modeling of the
rehabilitation robot and the design of the nonlinear extended state observer (NESO).

Objective:
To address the problem of trajectory tracking errors caused by the rehabilitation robot
when the patient's muscle tension changes, a method based on optimizing the nonlinear function
within the NESO is proposed.

Methods:
First, a mathematical model of the upper-limb rehabilitation robot is established to obtain
the dynamic relationship between the robot's velocity and the input voltage. Second, the nonlinear
function of NESO is optimized by adjusting the gain values of the sine and tangent functions to effectively estimate the muscle tension and reduce the problem of accumulative error due to changes
in muscle tension. Finally, comparative simulations of trajectory tracking including the optimized
nonlinear function as well as the sine, tangent and power functions are performed on the MATLAB
platform.

Results:
NESO is constructed to estimate changes in muscle tension based on sine, tangent, and
power functions, as well as optimized nonlinear functions. The equivalent gain values of each function and the muscle tension estimation curves of NESO are compared. The simulation results show
that the equivalent gain value of the optimized nonlinear function acting in NESO is increased to
more than 8 and the convergence time is reduced by 11.9% accordingly. This conclusion is validated by simulations and practical tests.

Conclusion:
The optimized nonlinear function shortens the estimation time of the NESO for
changes in muscle tension, which can provide a reference value for the design of observers for upper-limb rehabilitation robots of patients in the flaccid paralysis stage.
The structure of traumatic brain injury in the city of Rostov-on-Don during the new coronavirus infection COVID 19
Authors: Efremov V. V. , Balyazin-Parfenov I. V. , Papazova A. V. , Magomedova A. Y. , Hantimeryan E. M. 
Published: June 2024

Objective: to study the frequency and structure of traumatic brain injury in the pre-ovoid, covid and post-ovoid periods in Rostov-on-Don.Materials and methods: to study the frequency and structure of traumatic brain injury in three years from 2019 to 2021 (in the pre-ovoid, covid and post-ovoid periods) according to the neurosurgical department and the department of combined trauma of the Emergency Medical Hospital No. 2 in Rostov-on-Don. Data processing using the IBM SPSS Statictic program version 26.0 using the χ2-Pearson criterion, in pairwise a posteriori comparative analysis, the χ2-Pearson criterion with Yates correction and likelihood correction were used. If the significance level is p<0.05, the differences are statistically significant.Results: in the pre-crisis period (2019), household trauma prevailed, the total number of hospitalized with TBI was 1,322. Of these, concussions accounted for 71%, brain contusions accounted for 28%, diffuse brain injury — 1%, street injury — 6.9%, transport injury — 6.81% and intentional injury — 24.1%. In the covid period (2020), the total number of patients admitted to the department decreased by 24%. The structure of the injury remained unchanged (concussions in 70% of cases, brain contusions in 28%, diffuse brain injury in 2%). In 2021 (completion of covid restrictions), the number of inpatient patients with TBI remained reduced (by 23%), the ratio of concussions, bruises, diffuse brain injuries remained the same.Conclusions: during the period of social isolation, there was a decrease in the number of hospitalized with TBI, which coincides with global indicators. The end of the restrictions associated with the pandemic is also characterized by a decrease in the number of patients admitted to the hospital with TBI. At the same time, a decrease in the ratio of the number of hospitalizations to the total number of deaths from head injury in 2019 and 2020 should be taken into account. from 19.83 to 14.98 in the Rostov region (according to the Federal State Statistics Service on the number of deaths from head injuries in 2019-2020), which reflects the level of accessibility of medical care. There was also a significant decrease in household, street, transport, school, sports and intentional types of TBI (p<0.05), while occupational injuries and trauma, the circumstances of which are unknown, did not significantly differ from the pre-pandemic indicators. Taking into account these results will improve the organization of emergency and emergency medical care for patients with TBI.
Kepatuhan Membayar Iuran Peserta Jaminan Kesehatan Nasional (JKN) Non Penerima Bantuan Iuran (Non-PBI) di Wilayah Pulau Jawa
Authors: Magdalena Magdalena , Ainy Asmaripa 
Published: June 2024

Program Jaminan Kesehatan Nasional (JKN) yang diselenggarakan oleh Badan Jaminan Sosial Kesehatan (BPJS) Kesehatan merupakan program pemerintah Indonesia sebagai upaya menuju Universal Health Coverage (UHC). Jaminan kesehatan nasional ditujukan untuk meningkatkan akses dan kualitas pelayanan kesehatan bagi masyarakat, mulai dari pelayanan promotif, preventif, kuratif, dan rehabilitatif. Kepatuhan peserta JKN Non PBI dalam pembayaran iuran JKN adalah penting, guna keberlanjutan pembiayaan program JKN. Tujuan dari penelitian ini adalah untuk mendeskripsikan kepatuhan membayar iuran JKN peserta Non PBI di enam provinsi di wilayah Pulau Jawa sebelum dan sesudah pandemi Covid-19. Penelitian ini merupakan penelitian deskriptif, Penelitian dilakukan dengan menggunakan data sekunder. Data yang digunakan dalam penelitian ini bersumber dari Badan Pusat Statistik (BPS) Republik Indonesia yakni data profil kabupaten/kota meliputi jumlah penduduk, penduduk usia produktif, status pekerjaan penduduk, penduduk tamatan SMA/sederajat, pendapatan per kapita penduduk dan data kepatuhan membayar iuran JKN dari website sistem monitoring evaluasi Dewan Jaminan Sosial Nasional (DJSN). Analisis data secara univariat yang disajikan melalui tabel, grafik dan peta digital. Didapatkan hasil bahwa provinsi Jawa Barat di tahun 2022 memiliki jumlah penduduk terbanyak. Penduduk berusia produktif, memiliki pekerjaan, dan tamatan SMA/sederajat terbanyak juga berada di provinsi Jawa Barat. Sedangkan pendapatan per kapita tertinggi ditemukan di provinsi DKI Jakarta. Trend kepatuhan membayar iuran JKN pada peserta Non PBI di Indonesia selama tahun 2018-2022 adalah fluktuatif. Penurunan kepatuhan selama terjadinya pandemi Covid-19 di tahun 2020 hingga 2021 dan kembali naik di tahun 2022 setelah pandemi Covid-19 berakhir. Pada tahun 2022, lebih dari separuh wilayah kabupaten/kota di Pulau Jawa menunjukkan persentase kepatuhan membayar iuran JKN di bawah persentase nasional (73,7%).
Cookies Kacang Hijau Subtitusi Tepung Pisang Ambon Sebagai Camilan Pada Atlet : Uji Kadar Kalium dan Tingkat Kesukaan
Authors: Nissa Khairun , Alza Yessi , Roziana Roziana 
Published: June 2024

Salah satu upaya pemenuhan gizi dan kelelahan otot atlet adalah dengan pemberian makanan berupa camilan. Camilan yang dapat diberikan pada atlet berupa cookies dari pisang dan kacang hijau. Pisang dan kacang hijau mengandung kalium dapat meningkatkan daya tahan atlet. Penelitian ini bertujuan mengetahui kadar kalium, kandungan zat gizi dan tingkat kesukaan terhadap cookies kacang hijau subtitusi tepung pisang ambon sebagai makanan selingan atlet. Penelitian ini bersifat eksperimental dengan desain penelitian rancangan acak lengkap, 4 perlakuan dan 3 kali ulangan. Pada penelitian ini digunakan empat macam variasi subtitusi tepung pisang ambon yaitu 0%, 15%, 30% dan 45%. Uji organoleptik pada penelitian ini menggunakan 25 panelis agak terlatih. Uji karbohidrat dengan metode luff schoorl dan uji kalium dengan metode SSA di Laboratorium Hasil Perikanan Universitas Riau. Analisis statistik dengan uji ANOVA, dan dilanjutkan dengan uji Duncan. Hasil penelitian ini menunjukkan bahwa formulasi cookies terpilih pada penelitian ini adalah cookies P1 (sangat suka-suka) dengan komposisi tepung pisang 15%. Sedangka nilai gizi cookies P1 memiliki kadar karbohidrat 44,63% dan kalium 2,62% yang lebih baik dibandingkan formulasi kontrol (P0) dengan kadar karbohidrat 40,38% dan kalium 0,34%.Cookies ini dapat dijadikan sebagai makanan selingan bagi atlet untuk mencegah kelelahan otot setelah berlatih.
Evaluasi Program Pemberian Makanan Tambahan (PMT) pada Ibu Hamil dalam Mencegah Stunting di Puskesmas Pattalassang pada Covid-19
Authors: Jayadi Yusma Indah , Adha A. Syamsiah , Tahar Titah Nurul Lathifah 
Published: June 2024

Program Pemberian Makanan Tambahan (PMT) diharapkan dapat menjadi salah satu solusi dalam mengatasi permasalahan Kekurangan Energi Kronis (KEK) pada ibu hamil. Studi ini bertujuan untuk mengevaluasi program pemberdayaan terkait PMT pada Ibu Hamil bersiko KEK yang berjalan di Puskesmas Pattalassang, Kabupaten Gowa. Penelitian dilaksanakan pada dari tanggal 7 – 11 Maret 2022. Subjek dalam penelitian terdiri dari tenaga pelaksana gizi, bidan desa dan kader posyandu. Instrumen data dalam penelitian ini menggunakan pedoman wawancara, observasi, form quesioner serta dokumentasi kegiatan. Untuk analisis datanya dilakukan dengan cara mentranskripkan secara tertulis hasil wawancara yang diperoleh kemudian dikelompokkan sesuai bidangnya masing-masing dan dilakukan penafsiran data secara narasi dan interpretasi kemudian dibandingkan dengan standar Kemenkes dan penelitan evaluasi sumber lainnya. Pelaksanaan program PMT secara umum berjalan dengan cukup baik. Pada indikator input, ditemukan bahwa pelaksanaan program PMT di Puskesmas Pattalassang masih terkendala pada kualitas dan kuantitas tenaga gizi. Selebihnya, terkait ketersediaan sarana, dana dan bahan pada umumnya telah memadai. Terkait pada indikator proses, pelaksanaannya sudah dapat dinilai baik melihat pendistribusian PMT Ibu Hamil telah dipertimbangkan dengan matang. Adapun pada indikator output, evaluasi proses pemantauan masih perlu ditingkatkan lagi. Berdasarkan hasil evaluasi tersebut, masih diperlukan peningkatan dalam upaya pemenuhan kualitas dan kuantitas sumber daya manusia serta pada pelaksanaan pencatatan dan pelaporan.
The Cumulative Effects of Conflict Drivers in the Sahel Region
Authors: Juvan Jelena 
Published: June 2024

Abstract
This article reflects on the complex security situation in the Sahel region, identifying the causes and drivers of conflicts. The main hypothesis underlying the article is that the security situation in the Sahel region is influenced by several different causes and conflict drivers which have cumulative effects, making conflict resolution extremely difficult. The first part of the article identifies the causes and drivers of conflict and classifies them into four main categories. In the second part, the article shows how the causes and drivers are interwoven, creating multiple spillover effects, making the Sahel region one of the most problematic regions in the world.
From Awareness to Action: Tetovo's Journey in Waste Management
Authors: Ashurmamadova Shahnoz , Osmani Xhenisa , Hasani Floreta , Tosheva Irina , Beqiri Florida , Caka Fjollë 
Published: June 2024

Abstract
Waste is increasing worldwide, causing many adverse impacts to the environment, human health, as well as the global climate. The increasing global waste generation trend is also reflected in North Macedonia, including Tetovo, where lower sustainable waste management practices pose an ongoing challenge.
This research offers a comprehensive examination of the city of Tetovo's waste management practices, focusing on its residents’ awareness levels and the undertaken strategies for sustainability. Building on existing research and new insights (especially those generated through the survey with Tetovo's citizens), it explores the historical evolution of waste management in Tetovo, highlighting past challenges and initiatives. With a focus on 'Municipal Public Services Co. (JPK) Tetova', the study navigates legislative hurdles, regional constraints, and potential for intermunicipal collaboration. Furthermore, it extracts Tetovo's community behaviors and awareness level through a conducted survey with citizens, which's insights reveal a significant gap between awareness and active citizen participation, underscoring the need for actionable recommendations.
Drawing upon theoretical frameworks like Waste Management Theory (WMT) and the “Zero Waste” concepts, this research explores opportunities for enhancing sustainability in Tetovo's waste management approach. Additionally, it discusses the implications of waste management on climate change, emphasizing the need for alignment with international standards to mitigate environmental impacts. Based on the literature review findings and survey data, the research proposes practical steps for improving waste management practices in Tetovo. These include collaborative initiatives, awareness-raising campaigns, educational programs, and measures for incentivizing compliance, all centered around a citizen-centric approach. By implementing these recommendations, Tetovo can progress towards a more efficient, environmentally conscious waste management system, benefiting present and future generations. Furthermore, stakeholders are encouraged to leverage the insights from this study to collaboratively implement effective strategies for fostering sustainable waste management practices, thereby empowering citizens to contribute actively to environmental conservation efforts.
Automation of Data Validation Processes in Banking: A Case Study on Validating Albanian Identity Numbers
Authors: Karamani Brunela 
Published: June 2024

Abstract
In the banking industry, data accuracy and integrity are paramount for ensuring regulatory compliance, operational efficiency, and risk management. However, manual data validation processes often lead to delays, errors, and inefficiencies, posing challenges for financial institutions. To address these issues, many banks are turning to automation to streamline data validation processes and improve accuracy. Using data automation, banks optimize time-consuming manual tasks such as data entry, validation, and retrieval by creating automated software processes that execute these tasks quickly and accurately. This case study examines how a hypothetical bank uses automation to improve data validation processes, focusing on Albanian Identity Numbers (AINs). By automating validation tasks, the bank enhances accuracy, compliance, and efficiency, mitigating the limitations of manual processes. The study outlines the implementation steps, discusses results, and highlights the importance of automating data validation in the banking sector.
Return Migration and Human Resources Development in Rural Areas: European Experience and Chinese Practice
Authors: Zhaoyang Liu , Rodríguez Samuel Esteban 
Published: June 2024

Objective: The purpose of this study is to explore and propose strategies to promote the return of rural population and effective human resource development in China, and to learn from the successful experience of European countries, especially their education and training systems, social security mechanisms, characteristic industries and infrastructure construction, in order to facilitate the implementation of the rural revitalization strategy.

Theoretical framework: Based on literature review, SWOT analysis, and international comparative research methods, this study builds a theoretical framework to identify the key elements of rural population return and human resource development, including vocational education and training, social security system, the cultivation of characteristic industries, the construction of infrastructure, etc., and reveals the similarities and differences between China and Europe in these fields through comparative analysis.

Design/Methods/Approach: Adopt a combination of qualitative and quantitative research methods, firstly, through an extensive literature review to build a theoretical foundation; Second, data from official and international agencies are used for quantitative analysis, including processing and visualizing data on rural residents' incomes, investment in education, and population structure. Subsequently, SWOT analysis was used to assess the current state of human resource development in China's rural areas. Finally, the data obtained are exhaustively analysed, combined with European cases and specific strategic suggestions are proposed.

Significance: The results of this study will provide a comprehensive strategic framework for human resource development in China's rural areas, emphasizing the implementation of multidimensional strategies such as optimizing investment in education, vocational training, and improving the social security system, which is of great practical importance to promote the healthy return of rural people and promote the sustainable development of the economy and economy. rural society. The proposed strategies can not only guide policy-making, but also provide a scientific basis for the development path of rural areas.