bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rising to the challenge: The motivation to champion routine intimate partner violence screening in rural emergency departments
Authors: Saberi Elham , Hutchinson Marie , Hurley John 
Published: August 2024

AbstractObjectiveTo understand the motivations of champions who worked to bring about system and practice change that supported routine screening for intimate partner violence (IPV) in two rural emergency departments (EDs).IntroductionPractice changes are required to achieve routine and effective identification and response to IPV. Nurses play a significant role in affecting such practice change. This paper identifies the motivations of champions in the ED setting who successfully brought about such change.SettingThe EDs of two Level 5 tertiary hospitals within a rural Local Health District (LHD) of New South Wales, Australia.ParticipantsTwenty‐three individuals who identified as champions and worked to introduce routine IPV screening in two rural hospital EDs.DesignQualitative longitudinal semi‐structured interviews employing a process of constant comparison and an interpretive framework to analyse data thematically. Interviews were carried out between June and August 2017 and again between July and August 2019.ResultsOver the period of the study, routine screening was established, and screening rates steadily increased from a low baseline to a significantly higher rate. Three aspects of champion motivation emerged from the analysis: formation of an identity as a champion, making a difference to a significant social justice issue and providing quality and community‐relevant care.ConclusionsThis study is the first study to report on champions and their motivation as they supported IPV practice change in the ED. The findings highlight the capacity for innovation in rural health services, with important implications for other settings looking to translate similar programs. Understanding motivating factors may assist in improved utilisation and support for champions. This is vital if champions are to bring about required practice change within their service and ensure the needs of individuals experiencing IPV are effectively met.
Aspirin hypersensitivity diagnostic index (AHDI): In vitro test for diagnosing of N‐ERD based on urinary 15‐oxo‐ETE and LTE4 excretion
Authors: Mastalerz Lucyna , Trąd Gabriela , Szatkowski Piotr , Ćmiel Adam , Gielicz Anna , Kacorzyk Radosław , Plutecka Hanna , Szaleniec Joanna , Gawlewicz‐Mroczka Agnieszka , Jakieła Bogdan , Sanak Marek 
Published: August 2024

AbstractBackground15‐oxo‐eicosatetraenoic acid (15‐oxo‐ETE), is a product of arachidonic acid (AA) metabolism in the 15‐lipoxygenase‐1 (15‐LOX‐1) pathway. 15‐oxo‐ETE was overproduced in the nasal polyps of patients with nonsteroidal anti‐inflammatory drug–exacerbated respiratory disease (N‐ERD). In this study we investigated the systemic biosynthesis of 15‐oxo‐ETE and leukotriene E4 (LTE4) and assessed their diagnostic value to identify patients with N‐ERD.MethodsThe study included 64 patients with N‐ERD, 59 asthmatics who tolerated aspirin well (ATA), and 51 healthy controls. A thorough clinical characteristics of asthmatics included computed tomography of paranasal sinuses. Plasma and urinary 15‐oxo‐ETE levels, and urinary LTE4 excretion were measured using high‐performance liquid chromatography and tandem mass spectrometry. Repeatability and precision of the measurements were tested.ResultsPlasma 15‐oxo‐ETE levels were the highest in N‐ERD (p < .001). A receiver operator characteristic (ROC) revealed that 15‐oxo‐ETE had certain sensitivity (64.06% in plasma, or 88.24% in urine) for N‐ERD discrimination, while the specificity was rather limited. Modeling of variables allowed to construct the Aspirin Hypersensitivity Diagnostic Index (AHDI) based on urinary LTE4‐to‐15‐oxo‐ETE excretion corrected for sex and the Lund‐Mackay score of chronic rhinosinusitis. AHDI outperformed single measurements in discrimination of N‐ERD among asthmatics with an area under ROC curve of 0.889, sensitivity of 81.97%, specificity of 87.23%, and accuracy of 86.87%.ConclusionsWe confirmed 15‐oxo‐ETE as a second to cysteinyl leukotrienes biomarker of N‐ERD. An index based on these eicosanoids corrected for sex and Lund‐Mackay score has a similar diagnostic value as gold standard oral aspirin challenge in the studied group of patients with asthma.
Innovative all‐in‐one exome sequencing strategy for diagnostic genetic testing in male infertility: Validation and 10‐month experience
Authors: Oud Manon S. , de Leeuw Nicole , Smeets Dominique F. C. M. , Ramos Liliana , van der Heijden Godfried W. , Timmermans Raoul G. J. , van de Vorst Maartje , Hofste Tom , Kempers Marlies J. E. , Stokman Marijn F. , D'Hauwers Kathleen W. M. , Faas Brigitte H. W. , Westra Dineke 
Published: August 2024

AbstractBackgroundCurrent guidelines indicate that patients with extreme oligozoospermia or azoospermia should be tested for chromosomal imbalances, azoospermia factor (AZF) deletions and/or CFTR variants. For other sperm abnormalities, no genetic diagnostics are recommended.ObjectivesTo determine whether exome sequencing (ES) with combined copy number variant (CNV) and single nucleotide variant (SNV) analysis is a reliable first‐tier method to replace current methods (validation study), and to evaluate the diagnostic yield after 10 months of implementation (evaluation study).Materials and MethodsIn the validation study, ES was performed on DNA of patients already diagnosed with AZF deletions (n = 17), (non‐)mosaic sex chromosomal aneuploidies or structural chromosomal anomalies (n = 37), CFTR variants (n = 26), or variants in known infertility genes (n = 4), and 90 controls. The data were analyzed using our standard diagnostic pipeline, with a bioinformatic filter for 130 male infertility genes. In the evaluation study, results of 292 clinical exomes were included.ResultsAll previously reported variants in the validation cohort, including clinically relevant Y‐chromosomal microdeletions, were correctly identified and reliably detected. In the evaluation study, we identified one or more clinically relevant genetic anomalies in 67 of 292 of all cases (22.9%): these included aberrations that could have been detected with current methods in 30 of 67 patients (10.2% of total), (possible) (mono)genetic causes in the male infertility gene panel in 28 of 67 patients (9.6%), and carriership of cystic fibrosis in nine of 67 patients (3.1%).ConclusionES is a reliable first‐tier method to detect the most common genetic causes of male infertility and, as additional genetic causes can be detected, in our evaluation cohort the diagnostic yield almost doubled (10.2%–19.8%, excluding CF carriers). A genetic diagnosis provides answers on the cause of infertility and helps the professionals in the counseling for treatment, possible co‐morbidities and risk for offspring and/or family members. Karyotyping will still remain necessary for detecting balanced translocations or low‐grade chromosomal mosaicism.
Are listed SMEs ready for the corporate sustainability reporting directive? Evidence from Italy
Authors: Pizzi Simone , Coronella Lorenzo 
Published: August 2024

AbstractThis paper explores the sustainability reporting practices of listed small‐ and medium‐sized enterprises (SMEs) in the context of the Corporate Sustainability Reporting Directive (CSRD). Utilizing institutional theory as a framework, this study employs dynamic panel data and logistic regressions to investigate how these SMEs respond to isomorphic pressures. The findings reveal a significant presence of mimetic isomorphism, where these companies tend to imitate the sustainability reporting behaviours of all listed companies, not just those of their direct SME competitors. Interestingly, the study also finds that geographical factors do not significantly influence the sustainability reporting practices of these SMEs. This research makes a notable contribution to the ongoing discussion about mandatory sustainability reporting in Europe, being one of the first in‐depth analyses of how European‐listed SMEs are adapting to new sustainability reporting regulations.
A novel index combining fecal immunochemical test, DNA test, and age improves detection of advanced colorectal adenoma
Authors: Inoue Yukari , Ishiguro Akiyo , Suehiro Yutaka , Kunimune Yuki , Yamaoka Yuko , Hashimoto Shinichi , Nakamura Katsuhiko , Goto Atsushi , Hamabe Koichi , Matsumoto Toshihiko , Tomochika Shinobu , Higaki Shingo , Fujii Ikuei , Suzuki Chieko , Koga Michiko , Tsutsumi Takeya , Lim Lay Ahyoung , Matsubara Yasuo , Yotsuyanagi Hiroshi , Nagano Hiroaki , Yamamoto Naoki , Sakaida Isao , Takami Taro , Nishioka Mitsuaki , Yamasaki Takahiro 
Published: August 2024

AbstractAlthough the fecal immunochemical test for hemoglobin (FIT) is a widely used screening test for colorectal cancer, it is not sensitive enough to detect advanced colorectal adenoma. To address this issue, we performed this study to investigate whether combining the FIT and fecal DNA testing of methylated somatostatin (SST) could improve diagnostic performance for advanced colorectal adenoma. We collected feces from 79 healthy subjects with negative results on colonoscopy, 43 patients with non‐advanced colorectal adenoma, 117 patients with advanced colorectal adenoma, and 126 patients with colorectal cancer. After fecal DNA was incubated with methylation‐sensitive restriction enzymes, SST methylation levels were measured by droplet digital PCR. Using logistic multivariate analysis, we established a prediction formula for detecting colorectal neoplasia and named it the FAMS (FIT, age, methylated SST) index. The diagnostic performance of a single use of FIT for advanced colorectal adenoma showed a sensitivity of 29.1% (34/117) and specificity of 89.3% (109/122). In contrast, the FAMS index showed a sensitivity of 56.4% (66/117) at a similar specificity point of 91.0% (111/122). Furthermore, even at the higher specificity point of 94.3% (115/122), the sensitivity was still higher than that of FIT, reaching 42.7% (50/117). As the FAMS index showed better diagnostic performance for advanced colorectal adenoma than a single use of FIT, the FAMS index could be a promising tool for detecting advanced colorectal adenoma.
Complication, vertical bone gain, volumetric changes after vertical ridge augmentation using customized reinforced PTFE mesh or Ti‐mesh. A non‐inferiority randomized clinical trial
Authors: Cucchi Alessandro , Bettini Sofia , Tedeschi Lucia , Urban Istvan , Franceschi Debora , Fiorino Antonino , Corinaldesi Giuseppe 
Published: August 2024

AbstractObjectiveThe aim of this non‐inferiority randomized clinical trial was to compare the surgical and healing complications, vertical bone gain, and volumetric bone changes after vertical ridge augmentation using two different approaches: customized Ti‐reinforced d‐PTFE mesh versus customized CAD/CAM Ti‐mesh.Materials and MethodsFifty patients with vertical bone defects were randomly treated with Ti‐reinforced d‐PTFE mesh (control group) or CAD/CAM Ti‐mesh (test group) and a mix of autogenous bone and deproteinized bovine bone matrix. Surgical and healing complication rates (SCR‐HCR), vertical bone gain (VBG), regenerated bone volume (RBV), and regeneration rates (RR and ERR) were recorded and analysed [significance level (α) of 0.05].ResultsOf the 50 patients, 48 underwent bone augmentation surgery. SCR were 4% and 12% in PTFE and Ti‐mesh, whereas HCR were 12.5% and 8.3%. VBG were 5.79 ± 1.71 mm (range: 3.2–8.8 mm) in the PTFE group and 5.18 ± 1.61 mm (range: 3.1–8.0 mm) in the Ti‐mesh group (p = .233), whereas RBV were 1.46 ± 0.48 cc and 1.26 ± 0.55. RR was 99.5% and 87.0%, demonstrating a statistically significant difference (p = .013). Finally, the values related to pseudo‐periosteum, bone density, and implant stability were similar in the two study groups. Osseointegration rates were 98.2% and 98.3%.ConclusionsThis study confirmed the non‐inferiority of customized CAD/CAM titanium meshes with respect to reinforced PTFE meshes in terms of surgical and healing complications. Although PTFE meshes showed higher vertical bone gain and regeneration rates than Ti‐meshes, no significant differences were found.
Effects of high‐intensity chronic noise on spatial memory in male versus female rats
Authors: Zhvania Mzia G. , Japaridze Nadezhda , Tizabi Yousef , Pochkhidze Nino , Lobzhanidze Giorgi 
Published: August 2024

AbstractThe detrimental effects of high‐intensity noise on the auditory system and emotional status, including the induction of anxiety, are well documented. Preclinical as well as epidemiological and clinical studies have solidly established differential responses between males and females to various stressful stimuli, including high‐intensity white noise (HIWN). However, whether chronic exposure to noise affects cognitive functions and whether this effect is sex dependent has not been adequately addressed. In this study, we used two cognitive test paradigms, such as the Morris water maze (MWM) and the multi‐branch maze (MBM), to test the effect of chronic HIWN on indices of spatial learning and memory in both male and female Wistar rats. Our findings indicate that daily (1 h) exposure to 100 dB of noise for 30 consecutive days induces different task‐dependent responses in male versus female rats. For example, in the acquisition phase of MWM, female rats exposed to noise outperformed their male counterparts at twice the speed. Similarly, in the MBM test, noise‐exposed female rats outperformed the male rats in reaching the nest box. It is clear from these studies that noise impairs cognitive functions twice as negatively in male rats as in female rats. Thus, sex‐related differences in spatial learning and memory in response to HIWN must be taken into consideration when investigating the neurobiological components and/or treatment modalities.
The effect of restructuring internationalized companies on performance: Evidence from European firms
Authors: Forcadell Francisco Javier , Romero‐Jordán Desiderio , Sanchez‐Riofrio Angelica , Guerras‐Martín Luis Ángel 
Published: August 2024

AbstractThis paper analyzes the effect of restructuring internationalized companies on financial performance. We hypothesize that companies implementing restructuring strategies in internationalized companies obtain better financial performance than non‐internationalized companies that restructure. Both strategies exploit resource complementarities that promote improved resource access, generation, and use. We empirically analyze a sample of 932 companies from 15 European Union countries from 1998 to 2011, including periods of economic growth and financial crisis. Our study extends the internationalization literature by demonstrating that internationalization improves financial performance (return on assets) for companies facing narrowing or refocusing their scope.
Effectiveness of mass marking of juvenile sterlet (Acipenser ruthenus) with alizarin red S stain on field detection
Authors: Šindler Martin , Buřič Miloš , Plesch Martin , Franta Pavel , Drozd Bořek 
Published: August 2024

AbstractSterlet (Acipenser ruthenus), one of the last sturgeons in the Danube basin, is regularly stocked in national and international restoration programs, but the efficacy of stocking has not yet been evaluated. Effectiveness of stocking should involve marking and evaluating growth and survival of juveniles. Chemical marking with alizarin red S (ARS) was evaluated to establish optimal ARS staining approaches for juvenile sterlet. Bathing in a 100–200 mg l−1 ARS concentration for 12 h had no affect on fish mortality or growth. Use of a green laser on the upper five external structures (dorsal, lateral, and ventral scutes and rostral and anal plates) allowed easy detection for at least a year. Simultaneous use of multiple external structures was effective for distinguishing stocked from wild fish without harm or sacrifice. We conclude that ARS staining enabled a cost‐effective, quick, and labour‐nonintensive way to mark sterlet, with a high‐field detectability and minimal previous experience required.
LOST AT SEA: MARITIME MODERNITY AND THE NEGOTIATION OF IDENTITY IN THEODOR STORM'S ‘HANS UND HEINZ KIRCH’
Authors: Hammarfelt Linda Karlsson 
Published: August 2024

ABSTRACTThis article explores the depiction of the sailor and the conflict between bourgeois life and its fluid ‘other’ in Theodor Storm's novella ‘Hans und Heinz Kirch’ (1883). The analysis brings together spatial theory, in particular Deleuze and Guattari's understanding of ‘smooth’ and ‘striated’ spaces, and reception aesthetics. Next to the ‘smooth’, fluid border of the ocean, the article identifies other in‐between areas which play a central role in the novella as spheres of negotiating story and identity: the sailor's skin as the border between self and other; and the omissions of language and narration. It argues that the many ‘Leerstellen’ of the text correspond to the openness of the sea and open up to a ‘travelling’ reading. Readers are invited to actively explore the open spaces and ambiguities of the text and thus contribute to the production of meaning. Placing Storm's novella in the context of maritime modernity and regarding correspondences between the narrative discourse and the conflict between ‘smooth’ and ‘striated’ space, this article offers a new perspective on Storm.
THE INFLUENCE OF BRIGITTE REIMANN'S FRANZISKA LINKERHAND ON THE POLITICAL SONGS OF GERHARD GUNDERMANN
Authors: Robb David 
Published: August 2024

ABSTRACTGerhard Gundermann was an East German open cast miner and ‘Liedermacher’ who died prematurely in 1998 at the age of forty‐three. Although he is known for his controversial involvement with the Stasi in his early career, very little has been written about his art, including the ‘Liedertheater’ work he performed with Brigade Feuerstein in the GDR. This article looks at the role of literary intertextuality in the productions of this group between 1978 and 1988. It specifically examines Gundermann's connection with Brigitte Reimann's socially critical novel Franziska Linkerhand, particular themes from which recur in his songs and theatrical scenes. These include ‘waiting’, as Gundermann and his contemporaries struggled to assert themselves, faced with the older generation's stranglehold on power and information. The Brigade Feuerstein productions will be examined against the background of Gundermann's own protracted conflict with the Sozialistische Einheitspartei Deutschlands (SED) in the years 1978 to 1984. Another theme of Franziska Linkerhand which appears in his work are the portraits of characters from the margins of society that conflict with ideal heroic depictions of workers as propagated by the SED. In the final decade of Gundermann's life, society's ‘losers’ continue to be portrayed in songs such as ‘Und musst du weinen’.
Natural killer cells and engagers: Powerful weapons against cancer
Authors: Bottino Cristina , Picant Valentin , Vivier Eric , Castriconi Roberta 
Published: August 2024

SummaryNatural killer (NK) cells are innate immune effectors whose functions rely on receptors binding cytokines, recognizing self‐molecules, or detecting danger signals expressed by virus‐infected or tumor cells. The potent cytotoxic potential makes NK cells promising candidates for cancer immunotherapy. To enhance their activity strategies include cytokine administration, blocking of immune checkpoints, and designing of antibody‐based NK cell engagers (NKCEs). NKCEs represent a cutting‐edge approach to cancer therapy: they strengthen the NK‐to‐target cell interactions and optimize tumor killing, possibly overcoming the immunosuppressive tumor microenvironment. NK cells belong to the innate lymphoid cells (ILCs) and are categorized into different subsets also including cells with a memory‐like phenotype: this complexity needs to be explored in the context of cancer immunotherapy, particularly when designing NKCEs. Two strategies to enhance NK cell activity in cancer patients can be adopted: activating patients' own NK cells versus the adoptive transfer of ex vivo activated NK cells. Furthermore, the capability of NKCEs to activate γδ T cells could have a significant synergistic effect in immunotherapy.
The function of antibodies
Authors: Daëron Marc 
Published: August 2024

SummaryAntibodies have multiple biological activities. They can both recognize and act on specific antigens. They can protect against and cause serious diseases, enhance and inhibit antibody responses, enable survival, and threaten life. Which among their many, often antagonistic properties explains that antibodies were selected half a billion years ago and transmitted to mammals across millions of generations? In other words, what is the function of antibodies? Here I examine how their structure endows antibodies with unique cognitive and effector properties that contribute to their multiple biological activities. I show that rather than specific properties, antibodies have large functional repertoires. They have a cognitive repertoire and an effector repertoire that are selected from larger available repertoires, themselves drawn at random from even larger virtual repertoires. These virtual repertoires provide the adaptive immune system with immense, constantly renewed, reservoirs of cognitive and effector functions that can be actualized at any time according to the context. I propose that such a flexibility, which enables living individuals to adapt to a rapidly changing environment, and even deal with an unknown future, may provide a better selective advantage than any particular function.
National Humiliation: Emotion, Narrative, and Conflict
Authors: Majeed Raamy 
Published: August 2024

ABSTRACTNational humiliation is increasingly being used as a way of explaining certain kinds of international conflict. In this article, I argue that while such explanations are presented on the back of plausible assumptions about emotion, such assumptions also make it unlikely that humiliation can play the myriad of explanatory roles attributed to it, for example, to explain the rise of Hitler, growing Chinese antagonism towards the West, Russia's invasion of Ukraine, and so on. In response, I consider some other ways humiliation may play a role in international conflict and argue that what are likely to be most relevant are not humiliating experiences, felt by individuals or groups, but rather humiliation narratives, which are often used as a discursive mechanism to justify conflict. This is important because it means a nation's willingness to engage in international conflict depends not on something which seems intractable (that is, the emotions felt by its citizens), but something more malleable: the narratives it accepts as frames for historical events.