bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in the proteome of Apis mellifera acutely exposed to sublethal dosage of glyphosate and imidacloprid
Authors: Maya-Aguirre Carlos Andrés , Torres Angela , Gutiérrez-Castañeda Luz Dary , Salazar Luz Mary , Abreu-Villaça Yael , Manhães Alex Christian , Arenas Nelson Enrique 
Published: July 2024

AbstractUncontrolled use of pesticides has caused a dramatic reduction in the number of pollinators, including bees. Studies on the effects of pesticides on bees have reported effects on both metabolic and neurological levels under chronic exposure. In this study, variations in the differential expression of head and thorax–abdomen proteins in Africanized A. mellifera bees treated acutely with sublethal doses of glyphosate and imidacloprid were studied using a proteomic approach. A total of 92 proteins were detected, 49 of which were differentially expressed compared to those in the control group (47 downregulated and 2 upregulated). Protein interaction networks with differential protein expression ratios suggested that acute exposure of A. mellifera to sublethal doses of glyphosate could cause head damage, which is mainly associated with behavior and metabolism. Simultaneously, imidacloprid can cause damage associated with metabolism as well as, neuronal damage, cellular stress, and impairment of the detoxification system. Regarding the thorax–abdomen fractions, glyphosate could lead to cytoskeleton reorganization and a reduction in defense mechanisms, whereas imidacloprid could affect the coordination and impairment of the oxidative stress response.
A Qualitative Investigation of Characteristics Impacting Clinical Decision-Making in Integrated Behavioral Health Care
Authors: Smith Ash M. , Prom Maria C. , Ng Lauren C. 
Published: July 2024

AbstractTo support implementation of integrated behavioral health care (IBHC) models in local settings, providers may benefit from clinical decision-making support. The present analysis examines perspectives on patient characteristics appropriate or inappropriate for, and currently managed within, IBHC at a large medical center to inform recommendations for provider decision-making. Twenty-four participants (n = 13 primary care providers; n = 6 behavioral health providers; n = 5 administrators) in an IBHC setting were interviewed. Thematic analysis was conducted with acceptable interrater reliability (κ = 0.75). Responses indicated behavioral health symptom and patient characteristics that impact perceptions of appropriateness for management in IBHC, with high variability between providers. Many patients with characteristics identified as inappropriate for IBHC were nonetheless currently managed in IBHC. Interactions between patient ability to engage in care and provider ability to manage patient needs guided decisions to refer a patient to IBHC or specialty care. A heuristic representing this dimensional approach to clinical decision-making is presented to suggest provider decision-making guidance informed by both patient and provider ability.
Adolescent Lifestyle Behaviour Modification and Mental Health: Longitudinal Changes in Diet, Physical Activity, Sleep, Screen Time, Smoking, and Alcohol Use and Associations with Psychological Distress
Authors: Smout Scarlett , Champion Katrina E. , O’Dean Siobhan , Halladay Jillian , Gardner Lauren A. , Newton Nicola C. 
Published: July 2024

AbstractThis study examines longitudinal behaviour change in six key lifestyle behaviours—sleep, physical activity (PA), sedentary recreational screen time, diet, alcohol use, and tobacco use—and associations with mental health in a large study of Australian adolescents. Change between baseline (Mage = 12.7, N = 6,639) and 3-year follow up (Mage = 15.7, N = 4445) was investigated. Generalised linear mixed effects regressions modelled associations between behaviour change and later psychological distress score adjusting for baseline behaviours, baseline psychological distress, social determinants, and school clustering. Changes over time in each of the behaviours were significantly associated with later psychological distress, whereby health-promoting behaviours were associated with reduced psychological distress and vice versa. When all behaviour changes were modelled together, significant effects remained for sleep, PA, vegetable consumption, junk food and SSB consumption, alcohol, and tobacco use. Results highlight the potential benefits of behaviour modification to reduce the progression of psychological distress in adolescence.
Clinical Outcomes of Rural Patients with Diabetes Treated by ECHO-Trained Providers Versus an Academic Medical Center
Authors: Bouchonville Matthew F. , Myaskovsky Larissa , Leyva Yuridia L. , Erhardt Erik B. , Unruh Mark L. , Arora Sanjeev 
Published: July 2024

Abstract
Background
Despite clinical practice guidelines prioritizing cardiorenal risk reduction, national trends in diabetes outcomes, particularly in rural communities, do not mirror the benefits seen in clinical trials with emerging therapeutics and technologies.

Objective
Project ECHO supports implementation of guidelines in under-resourced areas through virtual communities of practice, sharing of best practices, and case-based learning. We hypothesized that diabetes outcomes of patients treated by ECHO-trained primary care providers (PCPs) would be similar to those of patients treated by specialists at an academic medical center.

Design
Specialists from the University of New Mexico (UNM) launched a weekly diabetes ECHO program to mentor dyads consisting of a PCP and community health worker at ten rural clinics.

Participants
We compared cardiorenal risk factor changes in patients with diabetes treated by ECHO-trained dyads to patients treated by specialists at the UNM Diabetes Comprehensive Care Center (DCCC). Eligible participants included adults with type 1 diabetes, type 2 diabetes on insulin, or diabetes of either type with A1c > 9%.

Main Measures
The primary outcome was change from baseline in A1c in the ECHO and DCCC cohorts. Secondary outcomes included changes in body mass index (BMI), blood pressure, cholesterol, and urine albumin to creatinine ratio (UACR).

Key Results
Compared to the DCCC cohort (n = 151), patients in the ECHO cohort (n = 856) experienced greater A1c reduction (−1.2% vs −0.6%; p = 0.02 for difference in difference). BMI decreased in the Endo ECHO cohort and increased in the DCCC cohort (−0.2 vs. +1.3 kg/m2; p = 0.003 for difference in difference). Diastolic blood pressure declined in the Endo ECHO cohort only. Improvements of similar magnitude were observed in low-density lipoprotein cholesterol in both groups. UACR remained stable in both groups.

Conclusions
ECHO may be a suitable intervention for improving diabetes outcomes in rural, under-resourced communities with limited access to a specialist.
Cost-Effectiveness of Laparoscopic Sleeve Gastrectomy for Chinese Patients
Authors: Yu Weihua , Chen Jionghuang , Fan Luqi , Yan Chenli , Zhu Linghua 
Published: July 2024

Abstract
Background
Laparoscopic sleeve gastrectomy (LSG) is the most popular bariatric surgery procedure in China. However, its cost-effectiveness in Chinese patients is currently unknown.

Objectives
This study aims to assess the cost-effectiveness of LSG vs no surgery in Chinese patients with severe and complex obesity, taking into account both healthcare expenses and the potential improvement in health-related quality of life (HRQoL).

Methods
A retrospective cohort study was conducted, encompassing 135 Chinese patients who underwent LSG between January 3, 2022 and December 29, 2022, at a major bariatric center. The study evaluated the cost-effectiveness from a healthcare service perspective, employing the incremental cost-effectiveness ratio (ICER) for quality-adjusted life years (QALYs) gained. The analyses compared LSG with the alternative of not undergoing surgery over a 1-year period, using actual data, and extended to a lifetime horizon by projecting costs and utilities at an annual discount rate of 3.0%. Subgroup analyses were undertaken to explore cost-effectiveness variations across different sex, age and BMI categories, and diabetes status, employing a one-way analysis of variance (ANOVA). To ensure the reliability of the findings, one-way and probabilistic sensitivity analyses were executed.

Results
The results indicated that 1-year post-LSG, patients achieved an average total weight loss (TWL) of (32.7 ± 7.3)% and an excess weight loss (EWL) of (97.8 ± 23.1)%. The ICER for LSG compared to no surgery over a lifetime was $4,327/QALY, significantly below the willingness-to-pay (WTP) threshold for Chinese patients with severe and complex obesity. From a lifetime perspective, LSG proved to be cost-effective for all sex and age groups, across all BMI categories, and for both patients with and without diabetes. Notably, it was more cost-effective for younger patients, patients with higher BMI, and patients with diabetes.

Conclusions
LSG is a highly cost-effective intervention for managing obesity in Chinese patients, delivering substantial benefits in terms of HRQoL improvement at a low cost. Its cost-effectiveness is particularly pronounced among younger individuals, those with higher BMI, and patients with diabetes.

Graphical Abstract
Systemic methotrexate (MTX) in early pregnancy: a retrospective study of a tertiary maternity hospital
Authors: Lutfi Ahmed , Hayes-Ryan Deirdre , Cottrell Elmarie , Greene Richard A. 
Published: July 2024

AbstractBackgroundMethotrexate (MTX) is used in clinical practice as a medical treatment option in patients with early pregnancy complications like ectopic pregnancy.AimsTo review systemic MTX therapy use in the first trimester of pregnancy in our hospital and to examine subsequent clinical outcomes.MethodsRetrospective review of all women treated with systemic MTX in early pregnancy identified from electronic prescription records from 1 January 2018 to 31 December 2020 at Cork University Maternity Hospital, Ireland. Relevant data was transcribed from electronic health records.ResultsIndications for treatment were tubal ectopic pregnancy (70%,n = 51), persistent pregnancy of unknown location (22%,n = 16) and caesarean scar pregnancy (7%,n = 5). Treatment was successful in 88% (n = 44) of tubal ectopic pregnancies with 73% (n = 37) and 14% (n = 7) of women receiving a single dose and repeated doses, respectively. Only 8% (n = 4) of tubal ectopic pregnancies required emergency surgery for subsequent tubal rupture. In 93% (n = 15) of cases of persistent pregnancy of unknown location, treatment was successful with one patient requiring uterine evacuation. Women with caesarean scar pregnancy were treated with combined MTX and uterine evacuation without complication.ConclusionsThe efficacy of medical treatment with systemic MTX for confirmed tubal ectopic pregnancy in our hospital is in line with national and international standards. Careful consideration should be given to treating caesarean scar pregnancy and persistent pregnancy of unknown location with systemic MTX. Systemic MTX use guided by clinicians specialised in early pregnancy complications and safe medication practices may improve treatment success and reduce adverse events.
Brain Networks, Neurotransmitters and Psychedelics: Towards a Neurochemistry of Self-Awareness
Authors: Mograbi Daniel C. , Rodrigues Rafael , Bienemann Bheatrix , Huntley Jonathan 
Published: July 2024

Abstract
Purpose of Review
Self-awareness can be defined as the capacity of becoming the object of one’s own awareness and, increasingly, it has been the target of scientific inquiry. Self-awareness has important clinical implications, and a better understanding of the neurochemical basis of self-awareness may help clarifying causes and developing interventions for different psychopathological conditions. The current article explores the relationship between neurochemistry and self-awareness, with special attention to the effects of psychedelics.

Recent Findings
The functioning of self-related networks, such as the default-mode network and the salience network, and how these are influenced by different neurotransmitters is discussed. The impact of psychedelics on self-awareness is reviewed in relation to specific processes, such as interoception, body ownership, agency, metacognition, emotional regulation and autobiographical memory, within a framework based on predictive coding.

Summary
Improved outcomes in emotional regulation and autobiographical memory have been observed in association with the use of psychedelics, suggesting higher-order self-awareness changes, which can be modulated by relaxation of priors and improved coping mechanisms linked to cognitive flexibility. Alterations in bodily self-awareness are less consistent, being potentially impacted by doses employed, differences in acute/long-term effects and the presence of clinical conditions. Future studies investigating the effects of different molecules in rebalancing connectivity between resting-state networks may lead to novel therapeutic approaches and the refinement of existing treatments.
How to Define and Meet Blood Pressure Targets After Traumatic Brain Injury: A Narrative Review
Authors: Kartal Ahmet , Robba Chiara , Helmy Adel , Wolf Stefan , Aries Marcel J. H. 
Published: July 2024

Abstract
Background
Traumatic brain injury (TBI) poses a significant challenge to healthcare providers, necessitating meticulous management of hemodynamic parameters to optimize patient outcomes. This article delves into the critical task of defining and meeting continuous arterial blood pressure (ABP) and cerebral perfusion pressure (CPP) targets in the context of severe TBI in neurocritical care settings.

Methods
We narratively reviewed existing literature, clinical guidelines, and emerging technologies to propose a comprehensive approach that integrates real-time monitoring, individualized cerebral perfusion target setting, and dynamic interventions.

Results
Our findings emphasize the need for personalized hemodynamic management, considering the heterogeneity of patients with TBI and the evolving nature of their condition. We describe the latest advancements in monitoring technologies, such as autoregulation-guided ABP/CPP treatment, which enable a more nuanced understanding of cerebral perfusion dynamics. By incorporating these tools into a proactive monitoring strategy, clinicians can tailor interventions to optimize ABP/CPP and mitigate secondary brain injury.

Discussion
Challenges in this field include the lack of standardized protocols for interpreting multimodal neuromonitoring data, potential variability in clinical decision-making, understanding the role of cardiac output, and the need for specialized expertise and customized software to have individualized ABP/CPP targets regularly available. The patient outcome benefit of monitoring-guided ABP/CPP target definitions still needs to be proven in patients with TBI.

Conclusions
We recommend that the TBI community take proactive steps to translate the potential benefits of personalized ABP/CPP targets, which have been implemented in certain centers, into a standardized and clinically validated reality through randomized controlled trials.
Nicotinamide riboside restores nicotinamide adenine dinucleotide levels and alleviates brain injury by inhibiting oxidative stress and neuroinflammation in a mouse model of intracerebral hemorrhage
Authors: She Jing , Zhang Hua , Xu Hui , Li Yan-Yan , Wu Jun-Chao , Han Rong , Lin Fang , Wang Yan , Sheng Rui , Gu Jin-hua , Qin Zheng-Hong 
Published: July 2024

Abstract
Hemorrhagic stroke is a global health problem owing to its high morbidity and mortality rates. Nicotinamide riboside is an important precursor of nicotinamide adenine dinucleotide characterized by a high bioavailability, safety profile, and robust effects on many cellular signaling processes. This study aimed to investigate the protective effects of nicotinamide riboside against collagenase-induced hemorrhagic stroke and its underlying mechanisms of action. An intracerebral hemorrhage model was constructed by stereotactically injecting collagenase into the right striatum of adult male Institute for Cancer Research mice. After 30 minutes, nicotinamide riboside was administered via the tail vein. The mice were sacrificed at different time points for assessments. Nicotinamide riboside reduced collagenase-induced hemorrhagic area, significantly reduced cerebral water content and histopathological damage, promoted neurological function recovery, and suppressed reactive oxygen species production and neuroinflammation. Nicotinamide riboside exerts neuroprotective effects against collagenase-induced intracerebral hemorrhage by inhibiting neuroinflammation and oxidative stress.
Tragia grandistipularis (Euphorbiaceae), a new species from Malawi
Authors: Cahen Daniel , Magombo Zacharia L. K. , Gillespie Lynn J. 
Published: July 2024

SummaryWe describe and illustrate Tragia grandistipularis (Euphorbiaceae), a new species from the Southern Region of Malawi, which is easily distinguished by its large stipules. We amend the key to the genus in Flora Zambesiaca to accommodate the new species. The new species is only known from a single population in a threatened habitat. Based on its limited known distribution and the threats to this habitat, we provisionally assess it as Critically Endangered (CR) with criteria B2ab(i,ii,iii,v) following the IUCN Red List categories and guidelines. We recommend further surveys to better understand the ecology and distribution of this new species.
Schmerztherapie in der Rheumatologie
Authors: Machold Klaus 
Published: July 2024

ZusammenfassungDie Therapie schmerzhafter rheumatischer Erkrankungen umfasst nichtmedikamentöse und medikamentöse Maßnahmen. Kurzdauernde Schmerzen sprechen meist gut auf nichtsteroidale Antirheumatika (NSAR) oder „reine“ Analgetika an, die Therapie chronischer Schmerzen erfordert meist den Einsatz einer Vielzahl ergänzender Methoden in individuell angepasster Kombination. Die Auswahl dieser Methoden orientiert sich an der Schmerzcharakteristik, der Schmerzlokalisation, der zugrunde liegenden Erkrankung und Begleit- bzw. Folgeerkrankungen wie Depression oder Organschäden. Für Ärzt:innen und Therapeut:innen, die Patient:innen mit chronischen Schmerzen behandeln, sind Kenntnisse des Spektrums der Schmerztherapie unabdingbar.
Time-Series Embeddings from Language Models: A Tool for Wind Direction Nowcasting
Authors: Alves Décio , Mendonça Fábio , Mostafa Sheikh Shanawaz , Morgado-Dias Fernando 
Published: July 2024

Abstract
Wind direction nowcasting is crucial in various sectors, particularly for ensuring aviation operations and safety. In this context, the TELMo (Time-series Embeddings from Language Models) model, a sophisticated deep learning architecture, has been introduced in this work for enhanced wind-direction nowcasting. Developed by using three years of data from multiple stations in the complex terrain of an international airport, TELMo incorporates the horizontal u (east–west) and v (north–south) wind components to significantly reduce forecasting errors. On a day with high wind direction variability, TELMo achieved mean absolute error values of 5.66 for 2-min, 10.59 for 10-min, and 14.79 for 20-min forecasts, processed within a swift 9-ms/step timeframe. Standard degree-based analysis, in comparison, yielded lower performance, emphasizing the effectiveness of the u and v components. In contrast, a Vanilla neural network, representing a shallow-learning approach, underperformed in all analyses, highlighting the superiority of deep learning methodologies in wind direction nowcasting. TELMo is an efficient model, capable of accurately forecasting wind direction for air traffic operations, with an error less than 20° in 97.49% of the predictions, aligning with recommended international thresholds. This model design enables its applicability across various geographical locations, making it a versatile tool in global aviation meteorology.
Derivation of two iPSC lines (KAIMRCi004-A, KAIMRCi004-B) from a Saudi patient with Biotin-Thiamine-responsive Basal Ganglia Disease (BTBGD) carrying homozygous pathogenic missense variant in the SCL19A3 gene
Authors: Alowaysi Maryam , Baadhaim Moayad , Al-Shehri Mohammad , Alzahrani Hajar , Badkok Amani , Attas Hanouf , Zakri Samer , Alameer Seham , Malibari Dalal , Hosawi Manal , Daghestani Mustafa , Al-Ghamdi Khalid , muharraq Mohammed , Zia Asima , Tegne Jesper , Alfadhel Majid , Aboalola Doaa , Alsayegh Khaled 
Published: July 2024

AbstractThe neurometabolic disorder known as biotin-thiamine-responsive basal ganglia disease (BTBGD) is a rare autosomal recessive condition linked to bi-allelic pathogenic mutations in the SLC19A3 gene. BTBGD is characterized by progressive encephalopathy, confusion, seizures, dysarthria, dystonia, and severe disabilities. Diagnosis is difficult due to the disease’s rare nature and diverse clinical characteristics. The primary treatment for BTBGD at this time is thiamine and biotin supplementation, while its long-term effectiveness is still being investigated. In this study, we have generated two clones of induced pluripotent stem cells (iPSCs) from a 10-year-old female BTBGD patient carrying a homozygous mutation for the pathogenic variant in exon 5 of the SLC19A3 gene, c.1264A > G (p.Thr422Ala). We have confirmed the pluripotency of the generated iPS lines and successfully differentiated them to neural progenitors. Because our understanding of genotype–phenotype correlations in BTBGD is limited, the establishment of BTBGD-iPSC lines with a homozygous SLC19A3 mutation provides a valuable cellular model to explore the molecular mechanisms underlying SLC19A3-associated cellular dysfunction. This model holds potential for advancing the development of novel therapeutic strategies.
Archetypes of climate change adaptation among large-scale arable farmers in southern Romania
Authors: Necula Cristiana , Rossing Walter A. H. , Easdale Marcos H. 
Published: July 2024

AbstractEffects of climate change and especially the associated climate variability require farmers to adjust to increasing frequencies of extreme events. In the agriculturally highly productive Romanian Plain, the frequency, intensity, and duration of heatwaves and drought have increased over the past 20 years. Although recent surveys revealed farmers’ awareness of climate change and enumerated a number of farm adaptation measures in the Romanian context, a systems approach to adaptation that allows conclusions on farm vulnerability and adaptive capacity is missing. Here, we use archetypal analysis to elucidate and characterize for the first time the types of adaptation responses of arable farmers in southern Romania. We conducted semi-structured interviews with 30 farmers managing 51,500 ha located across the southern lowlands of Romania, selected for their diversity of management approaches. Farmers were asked about experienced climatic disturbances, crop production losses during the most extreme events over the past 5–10 years, and the adaptation measures they implemented over that period of time. In addition, structural characteristics of the farm were recorded. The adaptation measures were classified and mapped on the efficiency, substitution, and redesign gradient used to classify sustainability stages. Results revealed three archetypes of adaptation, consisting of measures at field and farm level ranging from predominantly efficiency-enhancing ones (e.g., crop choice and management and risk insurance) to complete farm redesign involving agrotechnical and financial management changes. Structural farm characteristics did not explain differences between farms in their association with one of the archetypes. Our approach and results show for the first time both the need for strengthening farmer-level support in one of Europe’s key food production areas and the lessons that can be drawn from the outlier adaptation examples. Current European and national policies offer opportunities for farmer organizations in Romania to make these conclusions actionable.