bluuebunny/crossref_metadata_2025_split huggingface dataset:
HPV18 E6/E7 activates Ca2+ influx to promote the malignant progression of cervical cancer by inhibiting Ca2+ binding protein 1 expression
Authors: Kang Cong , Qiu Lei , Duo Yali , Bi FengLing , Liu Zhongjie , Wang Jing , Zheng Lei , Zhao Ning 
Published: August 2024

AbstractMounting studies have shown that the oncoproteins E6 and E7 encoded by the human papillomavirus (HPV) genome are essential in HPV‐induced cervical cancer (CC). Ca2+ binding protein 1 (CABP1), a downstream target of HPV18‐positive HeLa cells that interferes with E6/E7 expression, was identified through screening the GEO Database (GSE6926). It was confirmed to be down‐regulated in CC through TCGA prediction and in vitro detection. Subsequent in vitro experiments revealed that knocking down E6/E7 inhibited cell proliferation, migration, and invasion, whereas knocking down CABP1 promoted these processes. Simultaneously knocking down CABP1 reversed these effects. Additionally, the results were validated in vivo. Previous studies have indicated that CABP1 can regulate Ca2+ channels, influencing Ca2+ influx and tumor progression. In this study, it was observed that knocking down CABP1 enhanced Ca2+ inflow, as demonstrated by flow cytometry and confocal microscopy. Knocking down E6/E7 inhibited these processes, whereas simultaneously knocking down E6/E7 and CABP1 restored the inhibitory effect of knocking down E6/E7 on Ca2+ inflow. To further elucidate that E6/E7 promotes CC progression by inhibiting CABP1 expression and activating Ca2+ influx, BAPTA/AM treatment was administered during CABP1 knockdown. It was discovered that Ca2+ chelation could reverse the effect of CABP1 knockdown on CC cells. In conclusion, our results offer a novel target for the diagnosis and treatment of HPV‐induced CC.
Genome wide screening to discover novel toxin–antitoxin modules in Mycobacterium indicus pranii; perspective on gene acquisition during mycobacterial evolution
Authors: Bahl Aayush , Rakshit Roopshali , Pandey Saurabh , Tripathi Deeksha 
Published: August 2024

AbstractMycobacterium indicus pranii (MIP), a benign saprophyte with potent immunomodulatory attributes, holds a pivotal position in mycobacterial evolution, potentially serving as the precursor to the pathogenic Mycobacterium avium complex (MAC). Despite its established immunotherapeutic efficacy against leprosy and notable outcomes in gram‐negative sepsis and COVID‐19 cases, the genomic and biochemical features of MIP remain largely elusive. This study explores the uncharted territory of toxin‐antitoxin (TA) systems within MIP, hypothesizing their role in mycobacterial pathogenicity regulation. Genome‐wide screening, employing diverse databases, unveils putative TA modules in MIP, setting the stage for a comparative analysis with known modules in Mycobacterium tuberculosis, Mycobacterium smegmatis, Escherichia coli, and Vibrio cholerae. The study further delves into the TA network of MAC and Mycobacterium intracellulare, unraveling interactive properties and family characteristics of identified TA modules in MIP. This comprehensive exploration seeks to illuminate the contribution of TA modules in regulating virulence, habitat diversification, and the evolutionary pathogenicity of mycobacteria. The insights garnered from this investigation not only enhance our understanding of MIP's potential as a vaccine candidate but also hold promise in optimizing tuberculosis drug regimens for expedited recovery.
The importance of academic advising for dual credit and early college high school students
Authors: Moreno Marissa 
Published: August 2024

AbstractAcademic advising for dual credit and early college high school students is significant to postsecondary matriculation and degree completion of these students after high school graduation. Unstructured advising can lead students to take excess credits and have an unclear path to a postsecondary credential. This study focused on the importance of academic advising, ensuring a clear path is identified for each student participating in a dual credit or early college high school program. A qualitative survey identifying high school personnel's understanding of advising, needs to better serve students, and current challenges facing high school counselors is discussed. Quantitative data landscapes student demographics and attempted versus completed credits for both dual credit and early college high school students at multiple high schools. Practitioner recommendations underscore the need for college advising by a college advisor who is familiar with the college advisement process versus a high school counselor who focuses on high school completion needs.
The role of career and technology dual enrollment programs in facilitating student postsecondary transition
Authors: Wingfield Katerina 
Published: August 2024

AbstractStates have introduced a range of strategies and legislative policies aimed at increasing college matriculation through readiness strategies and initiatives that offer strong collaboration between secondary and postsecondary education. Early college high school (ECHS) models are one‐way that colleges, primarily community colleges, can serve underrepresented students in their journey to postsecondary opportunities. Additionally, pathways in technology (P‐TECH) models further connect students' academic experience to workforce opportunities and the acquisition of relevant skills. This article highlights the benefits connected to dual enrollment, the design of ECHS and P‐TECH models, and provides recommendations for strategy considerations when implementing these opportunities for students.
Adalimumab‐induced leukocytoclastic vasculitis in a patient with ankylosing spondylitis: A case report
Authors: Khabbazi Alireza , Hajialilo Mehrzad , Tahsini Tekantapeh Sepideh , Farshchi Tabrizi Sahar , Salehi Alireza 
Published: August 2024

Clinical Key MessageIn patients receiving anti‐TNF‐α drugs for ankylosing spondylitis, monitoring purpuric and ischemic skin lesions is crucial. This case underscores the significance of identifying and addressing drug‐induced vasculitis while stressing the necessity for prompt evaluation and exploration of alternative treatment options to safeguard patient well‐being.AbstractThe case discusses a 38‐year‐old female with a history of ankylosing spondylitis (AS) who presented with skin lesions, including purpuric skin lesions and ischemia of her right foot digits, after initiating treatment with adalimumab. After excluding other potential causes, such as infections and malignancies, the patient received a diagnosis of moderate‐sized vascular vasculitis associated with adalimumab use. Discontinuation of adalimumab and treatment with high dose glucocorticoids and intravenous pulse of cyclophosphamide resulted in the resolution of her ischemic lesions. This case underscores the importance of considering drug‐related side effects in patients with new skin lesions, particularly in the context of rheumatic diseases such as AS.
Desmoplastic infantile astrocytoma/ ganglioglioma in a pediatric onset multiple sclerosis patient: A case report
Authors: Jahani Shima , Moghadasi Abdorreza Naser 
Published: August 2024

Key Clinical MessageHere we present a co‐occurrence of a non‐typical presentation of DIG/DIA and multiple sclerosis in a 13‐year‐old female. Our case highlights how a thorough investigation prior to treatment is needed in patients with such condition to choose proper management for better prognosis.
Redo‐TAVR for bioprosthetic valve degeneration with obvious neoplasm in a left cerebral infarction patient
Authors: Liu Weili , Li Dacheng , Qu Zhanjun , Tang Guozhang , Liu Song , Li Yanchao , Jiang Lei 
Published: August 2024

Key Clinical MessageIn recent years, it is necessary to Redo‐TAVR for the patients with bioprosthetic valve degeneration. This case report described a unique instance to successfully Redo‐TAVR a patient with bioprosthetic valve degeneration, in addition, with left cerebral infarction and renal insufficiency.AbstractOver time, more and more patients have bioprosthetic valve degeneration either used in SAVR or TAVR. In order to solve the produced problems due to the degenerated bioprosthetic valve, Redo‐TAVR was increasingly popular due to its safe and efficiency especially for the high risk and complicated symptoms patients. In this case, the patient with left cerebral infarction and renal insufficiency has exhibited severe regurgitation and obvious neoplasm around the previous replaced aortic valve. For the patient with complicated symptoms, we did not image for this patient and only used CT to determine the position and angle for the Redo‐TAVR on the base of metal stent for the previous replaced aortic valve. During the Redo‐TAVR process, for fear of the obvious neoplasm slipping from the previous replaced aortic valve to embolism of important organs, before carrying out the Redo‐TAVR, cerebral protection device, temporary pacemaker, and coronary artery protection device were utilized in order to avoid the damage for the important organs from the obvious neoplasm slipping from the previous replaced aortic valve. The surgery was successful and the patient recovered well. The patient's symptoms of chest tightness and suffocation have been greatly reduced.
Ruthenium Nanoparticles within Carbon Spheres for Efficient Ammonia Decomposition
Authors: Rendon‐Patiño A. , Mateo D. , Duran‐Uribe S. , Sepulveda‐Escribano A. , Gascon J. , Ramos‐Fernandez Enrique V. 
Published: August 2024

AbstractThe one step hydrothermal synthesis of encapsulated ruthenium nanoparticles on carbon results in solids displaying high potential in photo‐thermal catalysis. The integration of ruthenium into the carbon matrix has a twofold effect: (i) enhanced stability through prevention of metal sintering and oxidation and (ii) improved photothermal response. As a result, high efficiencies are achieved in the photo‐thermal decomposition of ammonia.
Review of Extrinsic Factors That Limit the Catalytic Performance of Transition Metal Dichalcogenides (TMDs) in Hydrogen Evolution Reactions (HER)
Authors: Muthu Jeyavelan , Khurshid Farheen , Hofmann Mario , Hsieh Ya‐Ping 
Published: August 2024

AbstractTransition metal dichalcogenides (TMDs) have garnered attention as potential catalysts for water splitting owing to their unique structures, diverse electronic properties, and composition from earth‐abundant elements. While certain TMD catalysts, notably MoS2, have shown promising activity for hydrogen evolution reactions (HER), achieving performance comparable to traditional platinum catalysts remains a challenge. While significant effort has been invested into understanding the effect of TMD's structural properties, such as defectiveness and crystalline phases, recent work has emphasized the role of extrinsic factors on HER. This review summarizes the current understanding of the impact of commonly overlooked electrocatalytic effects that exhibit an enhanced importance in TMD‐based HER. By combining recent advances in theoretical modeling and experimental work, we review the dominating effects of extrinsic factors including electronic resistance, interfacial barriers, surface roughness, oxidation, and valence impurities. Our work aims to provide insights into optimizing TMDs as highly efficient catalysts for HER, facilitating future advancements in hydrogen generation technology.
Is Cobalt in Li‐Rich Layered Oxides for Li‐Ion Batteries Necessary?
Authors: Choi Hyeongseon , Schuer Annika Regitta , Moon Hyein , Melinte Georgian , Kim Guk‐Tae , Asenbauer Jakob , Kazzazi Arefeh , Kuenzel Matthias , Passerini Stefano 
Published: August 2024

AbstractCobalt is considered an essential element for layered cathode active materials supporting enhanced lithium‐ion conductivity and structural stability. Herein, we investigated the influence of Co concentration on the physicochemical properties and electrochemical performance of lithium‐rich layered oxides (LRLOs) with different Co content (Li1.2Ni0.2‐x/2Mn0.6‐x/2CoxO2, x=0, 0.04, and 0.08). Though the presence of Co grants structural stability to LRLOs, superior long‐term cycling stability is achieved with the Co‐free LRLO retaining 88.1 % of the initial specific capacity (vs. 75.9 % of Li1.2Ni0.16Mn0.56Co0.08O2) after 300 galvanostatic cycles at 250 mA g−1 (1 C). The chemical stability on the surface of LRLOs containing Co declines faster, indicating a higher bulk structural stability not being the primary determinant of the LRLOs’ cycling performance. Ex‐situ investigations indicate that the superior cycling stability of Co‐free LRLO is obtained by reducing the Mn‐related redox at discharge, which contributes to the large degree of polarization and low energy efficiency. Finally, the full‐cell configured with the optimized LRLO as cathode and graphite anode delivers an energy density of 464 Wh kg−1 at C/10, and 74.4 % and 94.3 % of retention in discharge specific capacity and average voltage at the 1000th cycle, demonstrating the applicability of Co‐free LRLO for sustainable LIBs.
Synthesis of Amorphous Nickel‐Cobalt Hydroxides for Ni−Zn Batteries
Authors: Ayyanusamy Poongodi , D Swathi Tharani. , Alphonse Ruby , Minakshi Manickam , Sivasubramanian R. 
Published: August 2024

AbstractIn this work we developed a hydrothermal method for synthesizing amorphous Ni−Co hydroxide (NC(OH)) and in the subsequent step crystalline NiCo2O4 (NCO) has been produced using water as the solvent. For nickel‐zinc batteries, NC(OH) was found to have superior performance to its NCO prepared by two‐step process. The thermal stability analysis exhibited the optimum temperature to obtain the NC(OH), and NCO electrode materials. The XRD pattern showed mixed phases containing both Ni and Co hydroxides (during the initial step) and in the subsequent step (calcined) the formation of cubic spinel structure was noticed. For NC(OH), aggregated particles with irregular morphology were observed while clustered nanorod‐like shapes were noticed for NCO samples. To be noted, that the nanorod morphology was obtained through a facile approach without employing any structure‐directing agent. Both NC(OH) and NCO were employed as cathodes for Ni−Zn battery studies against Zn foil anode with a polyamide‐based separator soaked in 6 M KOH saturated with ZnO additive was used as electrolyte. The Ni−Zn cell was fabricated in CR2032 coin cell configuration. The electrochemical studies such as cyclic voltammetry (CV) showed the characteristic redox peaks for NC(OH) sample exhibiting high peak current compared to its NCO counterpart. The NC(OH) had a capacity of 268 mAh g−1 against 120 mAh g−1 for NCO at a current density of 1 Ag−1. The cell was able to retain 85 % of the capacity at the end of 500 cycles and showed remarkable rate capability. The Ni−Zn battery presents energy and power densities of 428.8 Wh Kg−1 and 2.68 kW Kg−1, respectively surpassing the normal values reported for aqueous rechargeable batteries. Owing to the presence of Ni and Co in hydroxide form (reduced crystallinity) the NC(OH) sample showed improved electrochemical activity. This work provides a facile approach and effective strategy for developing bimetallic hydroxides for optimal energy storage performance.
Leveraging neural networks to estimate parameters with confidence intervals
Authors: Mathias Nigel , Weir Lauren , Corbett Brandon , Mhaskar Prashant 
Published: August 2024

AbstractThis manuscript presents a proof of concept for the estimation of parameters in a bioprocess while providing reliable confidence intervals. Specifically, Bayesian inference is used to estimate the uncertainty in the prediction of a parameter due to the presence of measurement noise in the process. The resultant joint probability distribution is utilized to infer the confidence interval of the resultant estimates. This method is numerically applied using a technique known as nested sampling. This algorithm iteratively samples parameters from a pre‐determined range of values to compare model predictions and obtain a probability density function. One challenge typically associated with this algorithm is in the determination of the prediction error, especially when a high‐fidelity dynamic model is being utilized. For the motivating example in the present manuscript, where a high‐fidelity simulated bioprocess is being considered, the use of the high‐fidelity model provided by Sartorius AG as part of the estimation algorithm poses computational challenges. To overcome this challenge, a universal approximator such as a parameterized neural network is used. This neural network is designed to simulate the results of the first principles model (while also capturing the dependence of the model parameters on the output), and once trained can provide near instantaneous results making the use of nested sampling computationally tractable for the application. Simulation results demonstrate the feasibility and capability of the proposed approach.
Effects of cellulose addition on sodium lignosulfonate pyrolysis: Product distribution and formation pathway
Authors: Ge Lichao , Zhao Can , Wang Yang , Qi Zhifu , Wang Ruikun , Yin Qianqian , Zhang Yuli , Xu Chang 
Published: August 2024

AbstractCopyrolysis of lignin and cellulose can effectively improve pore structure and optimize product distribution. Therefore, the distribution, characteristics, components, and formation mechanism of the copyrolysis products of cellulose and sodium lignosulfonate were studied. The pyrolysis of sodium lignosulfonate was effectively inhibited by cellulose, especially when the amount of doped cellulose was 40 wt.%, and tubes presumed to be carbon nanotubes were prepared under these conditions. For bio‐oil, the contents of phenol, 2‐methoxy‐, and 4‐aminopyridine increased with decreasing amounts of doped cellulose. However, cellulose substantially reduced the content of 2‐furanmethanol. H2, CO2, CO, and CH4 were the main components of the biogas; among them, H2 was the most abundant component in the biogas. Considering the characteristics of the three‐phase product, a higher C content in the volatiles (especially bio‐oil) can promote the formation of carbon nanotubes. Finally, the formation mechanism and interactions of the main components in the volatiles of cellulose and sodium lignosulfonate were proposed.
Association Between Phenotypic Age and the Risk of Mortality in Patients With Heart Failure: A Retrospective Cohort Study
Authors: Xu Xuhong , Xu Zhiqi 
Published: August 2024

ABSTRACTBackgroundChronological age (CA) is an imperfect proxy for the true biological aging state of the body. As novel measures of biological aging, Phenotypic age (PhenoAge) and Phenotypic age acceleration (PhenoAgeAccel), have been shown to identify morbidity and mortality risks in the general population.HypothesisPhenoAge and PhenoAgeAccel might be associated with mortality in heart failure (HF) patients.MethodsThis cohort study extracted adult data from the National Health and Nutrition Examination Survey (NHANES) databases. Weighted univariable and multivariable Cox models were performed to analyze the effect of PhenoAge and PhenoAgeAccel on all‐cause mortality in HF patients, and hazard ratio (HR) with 95% confidence intervals (CI) was calculated.ResultsIn total, 845 HF patients were identified, with 626 all‐cause mortality patients. The findings suggested that (1) each 1‐ and 10‐year increase in PhenoAge were associated with a 3% (HR = 1.03, 95% CI: 1.03–1.04) and 41% (HR = 1.41, 95% CI: 1.29–1.54) increased risk of all‐cause mortality, respectively; (2) when the PhenoAgeAccel < 0 as reference, the ≥ 0 group was associated with higher risk of all‐cause mortality (HR = 1.91, 95% CI = 1.49–2.45). Subgroup analyses showed that (1) older PhenoAge was associated with an increased risk of all‐cause mortality in all subgroups; (2) when the PhenoAgeAccel < 0 as a reference, PhenoAgeAccel ≥ 0 was associated with a higher risk of all‐cause mortality in all subgroups.ConclusionOlder PhenoAge was associated with an increased risk of all‐cause mortality in HF patients. PhenoAge and PhenoAgeAccel can be used as convenient tools to facilitate the identification of at‐risk individuals with HF and the evaluation of intervention efficacy.
Virtual and in Vitro Screening Employing a Repurposing Approach Reveal 13‐cis‐Retinoic Acid is a PTP1B Inhibitor
Authors: Del Carmen Navarrete‐Mondragón Reyna , Cortés‐Benítez Francisco , Elena Mendieta‐Wejebe Jessica , González‐Andrade Martin , Pérez‐Villanueva Jaime 
Published: August 2024

AbstractCurrent treatments for type 2 diabetes (T2D) mainly rely on exercise, dietary control, and anti‐diabetic drugs to enhance insulin secretion and improve insulin sensitivity. However, there is a need for more therapeutic options, as approved drugs targeting different pharmacological objectives are still unavailable. One potential target that has attracted attention is the protein tyrosine phosphatase 1B (PTP1B), which negatively regulates the insulin signaling pathway. In this work, a comprehensive computational screening was carried out using cheminformatics and molecular docking on PTP1B, employing a rigorous repurposing approach. The screening involved approved drugs and compounds under research as anti‐diabetics that bind to targets such as peroxisome proliferator‐activated receptor gamma (PPAR‐γ) and α‐glucosidase. Several computational hits were then meticulously tested in vitro against PTP1B, with 13‐cis‐retinoic acid (3a) showing an IC50 of 0.044 mM and competitive inhibition. Molecular dynamics studies further confirmed that 3a can bind to the catalytic binding site of PTP1B. Finally, 3a is the first time it has been reported as an inhibitor of PTP1B, making it a potentially valuable candidate for further studies in D2T treatment.
Bio‐Inspired Adaptive and Responsive Protein‐Based Materials
Authors: Zhang Yingying , Zhao Qi , Zhang Jingjiao , Wei Shuo , Tao Fei , Yang Peng 
Published: August 2024

AbstractIn nature, the inherent adaptability and responsiveness of proteins play a crucial role in the survival and reproduction of organisms, enabling them to adjust to ever‐changing environments. A comprehensive understanding of protein structure and function is essential for unraveling the complex biological adaptive processes, providing new insights for the design of protein‐based materials in advanced fields. Recently, materials derived from proteins with specific properties and functions have been engineered. These protein‐based materials, distinguished by their engineered adaptability and responsiveness, range from the nanoscale to the macroscale through meticulous control of protein structure. First, the review introduces the natural adaptability and responsiveness of proteins in organisms, encompassing biological adhesion and the responses of organisms to light, magnetic fields, and temperature. Next, it discusses the achievements in protein‐engineered adaptability and adhesion through protein assembly and nanotechnology, emphasizing precise control over protein bioactivity. Finally, the review briefly addresses the application of protein engineering techniques and the self‐assembly capabilities of proteins to achieve responsiveness in protein‐based materials to humidity, light, magnetism, temperature, and other factors. We hope this review will foster a multidimensional understanding of protein adaptability and responsiveness, thereby advancing the interdisciplinary integration of biomedical science, materials science, and biotechnology.