bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases: American Society of Clinical Oncology Clinical Practice Guideline
Authors: Ramakrishna Naren , Temin Sarah , Chandarlapaty Sarat , Crews Jennie R. , Davidson Nancy E. , Esteva Francisco J. , Giordano Sharon H. , Gonzalez-Angulo Ana M. , Kirshner Jeffrey J. , Krop Ian , Levinson Jennifer , Modi Shanu , Patt Debra A. , Perez Edith A. , Perlmutter Jane , Winer Eric P. , Lin Nancy U. 
Published: May 2014

Purpose To provide formal expert consensus–based recommendations to practicing oncologists and others on the management of brain metastases for patients with human epidermal growth factor receptor 2 (HER2) –positive advanced breast cancer. Methods The American Society of Clinical Oncology (ASCO) convened a panel of medical oncology, radiation oncology, guideline implementation, and advocacy experts and conducted a systematic review of the literature. When that failed to yield sufficiently strong quality evidence, the Expert Panel undertook a formal expert consensus–based process to produce these recommendations. ASCO used a modified Delphi process. The panel members drafted recommendations, and a group of other experts joined them for two rounds of formal ratings of the recommendations. Results No studies or existing guidelines met the systematic review criteria; therefore, ASCO conducted a formal expert consensus–based process. Recommendations Patients with brain metastases should receive appropriate local therapy and systemic therapy, if indicated. Local therapies include surgery, whole-brain radiotherapy, and stereotactic radiosurgery. Treatments depend on factors such as patient prognosis, presence of symptoms, resectability, number and size of metastases, prior therapy, and whether metastases are diffuse. Other options include systemic therapy, best supportive care, enrollment onto a clinical trial, and/or palliative care. Clinicians should not perform routine magnetic resonance imaging (MRI) to screen for brain metastases, but rather should have a low threshold for MRI of the brain because of the high incidence of brain metastases among patients with HER2-positive advanced breast cancer.
Quantification of Serum IgG Subclasses by Use of Subclass-Specific Tryptic Peptides and Liquid Chromatography–Tandem Mass Spectrometry
Authors: Ladwig Paula M , Barnidge David R , Snyder Melissa R , Katzmann Jerry A , Murray David L 
Published: May 2014

AbstractBACKGROUNDMeasurement of IgG subclasses is a useful tool for investigation of humoral immune deficiency in the presence of total IgG within reference intervals and IgG4-related disease. Nephelometry has been the method of choice for quantification. We describe an LC-MS/MS method that can multiplex all 4 subclasses along with total IgG by use of either IgG subclass-specific peptide stable isotope–labeled internal standards or a surrogate digest standard for quantification and does not rely on antigen/antibody reactions.METHODSWe combined serum with labeled internal peptide standards and intact purified horse IgG. Samples were denatured, reduced, alkylated, and digested. We analyzed the digested serum by LC-MS/MS for IgG subclasses 1–4 and total IgG.RESULTSWe assayed 112 patient sera by LC-MS/MS and immunonephelometry. The mean of the slopes and R2 values for IgG1, IgG2, IgG3, IgG4, and IgG were 1.18 and 0.93, respectively. Interassay imprecision for the LC-MS/MS method was &lt;15% for total IgG and subclasses and was slightly improved by use of a calibrator peptide from an exogenous horse IgG. Summed total IgG correlated with the measured total IgG within 10%. Reference intervals and analytical measuring range were all similar to our previous validation data for the immunonephelometry assays.CONCLUSIONSTotal IgG and IgG subclasses 1, 2, 3, and 4 can be quantified by LC-MS/MS with performance comparable to nephelometry.
PO.EX em EXPO (ou POesia EXperimental em EXPOsição): Ernesto Melo e Castro, António Barros e Silvestre Pestana na Casa da Escrita
Authors: Athayde Manaíra Aires 
Published: May 2014

Recensão crítica de três exposições: Ernesto MELO E CASTRO, Do Leve à Luz, de 03 de outubro a 02 de novembro de 2012. António BARROS, Progestos_Obgestos, de 30 de novembro a 21 de dezembro de 2012. Silvestre PESTANA, Povo Novo Virtual, de 08 de fevereiro a 01 de março de 2013. Ciclo NAS ESCRITAS PO.EX, Casa da Escrita, Coimbra, Portugal. DOI: http://dx.doi.org/10.14195/2182-8830_1-1_10
Fragmentación y Edición en el Libro del Desasosiego
Authors: Giménez Diego 
Published: May 2014

El presente artículo sostiene que las diferentes ediciones del Livro do Desassossego son en cierta manera una desfiguración en la medida que toman decisiones que el escritor no tomó sobre variables textuales y selección de fragmentos. Dentro de la modernidad, donde el «Livro» acontece como horizonte utópico, Pessoa presenta una escritura que no cierra y que, por tanto, deja abierta a la interpretación. Asimismo, intentaré desarrollar cómo la mediación (interpretación) sobre un texto queda reflejada en elementos gráficos que crean significado. El proceso de escritura pasa por diferentes etapas desde el momento inicial en que el escritor plasma sobre el papel la primera letra hasta la publicación de lo escrito en el formato que sea. La edición digital puede ser concebida como una forma de poner de manifiesto que la escritura se basa en un proceso de selección.Abstract This article argues that the various editions of the Book of Disquiet represent some defacement. The editor makes decisions that the writer did not take on textual variables and selection of fragments. In modernity the "book" emerges as a utopian horizon. Pessoa's writing is not finished and, therefore, remains open to interpretation. Also, I'll try to show how mediation (interpretation) upon a text is reflected in graphic elements that create meaning. The writing process goes through various stages from the initial inscription of letters on paper to the moment of publication in whatever format. A digital edition can be conceived as a way to show that writing is based on a selection process. DOI: http://dx.doi.org/10.14195/2182-8830_1-1_3
'As Únicas Coisas Nobres Que a Vida Contém'
Authors: Silvestre Osvaldo Manuel 
Published: May 2014

No Livro do Desassossego afirma-se a certa altura que «Ver e ouvir são as únicas coisas nobres que a vida contém. Os outros sentidos são plebeus e carnais.» O que sucede se na nossa leitura de Pessoa, e levando à letra as implicações desta afirmação, substituirmos o visível pelo óptico e o auditivo pelo acústico? Ou seja, se lermos o sujeito pessoano não tanto como um corpo-sem-órgãos em permanente produção de sensações, mas antes como um corpo que solicita os média (e os aparelhos) enquanto pré-condição da sua exteriorização?AbstractIn Livro do Desassossego (The Book of Disquiet) we can read that "To see and to listen are the only noble things that life comprehends. All other senses are plebeian and carnal." What happens if in our approach to Pessoa we read this affirmation straightforwardly, replacing the visible with the optic and the auditory with the acoustic? In other words, what if we read Pessoa´s subject not just as a body-without-organs constantly producing sensations, but instead as a non-body that requires media (and artifacts) as a prerequisite for its exteriorization? DOI: http://dx.doi.org/10.14195/2182-8830_1-1_5
Platão no Ribatejo: Notas sobre as "Notas"
Authors: Namora Ricardo 
Published: May 2014

A partir das “Notas para a recordação do meu mestre Caeiro”, de Álvaro de Campos, pretendem discutir-se as implicações da atribuição de um estatuto tutelar ao primeiro no contexto do simpósio da heteronomia. Para além disso, serão descritos outros tópicos, a saber: i) a possibilidade de uma arqueologia dos heterónimos pelo lado dos afectos; ii) a materialidade individual correlativa dos heterónimos; iii) as possibilidades materiais do real e respectivas consequências epistemológicas.AbstractSpringing from “Notas para a recordação do meu mestre Caeiro”, by Álvaro de Campos, this is a discussion on the implications that follow from the attribution of guardianship status to Caeiro within the heteronomy symposium. Moreover, other important topics will be described, notably: i) the possibility of an archaeology of the heteronyms from the affections standpoint; ii) the correlative individual materiality of the heteronyms; iii) the material possibilities of the real and its epistemological consequences. DOI: http://dx.doi.org/10.14195/2182-8830_1-1_6
Synthesis and Properties of Superparamagnetic Y-Fe2O3
Authors: Kotsyubynsky V.O. , Moklyak V.V. , Hrubiak A.B. 
Published: May 2014

Method of nanodispersed g-Fe2O3 synthesis by thermal decomposition of iron citrate is proposed. The investigations of obtained oxides crystal­line and magnetic structures are done. Nanodispersed g-Fe2O3 with sizes of coherent scattering regions about 4-7 nm was is only one phase after gel sintering at 200, 250 and 300оС; the particles of synthesized materials are in a state of magnetic ordering and in superparamagnetic state. The influence of mag­netic dipole interparticles interaction on parameters of Moss­bauer spectra is observed. The phenomenological mo­del of the differences between nanodispersed g-Fe2O3 magnetic micro­structures ob­tained after annealing at different tem­pe­ra­tu­res is presented.
Practice-Tailored Facilitation to Improve Pediatric Preventive Care Delivery: A Randomized Trial
Authors: Meropol Sharon B. , Schiltz Nicholas K. , Sattar Abdus , Stange Kurt C. , Nevar Ann H. , Davey Christina , Ferretti Gerald A. , Howell Diana E. , Strosaker Robyn , Vavrek Pamela , Bader Samantha , Ruhe Mary C. , Cuttler Leona 
Published: May 2014

OBJECTIVE:
Evolving primary care models require methods to help practices achieve quality standards. This study assessed the effectiveness of a Practice-Tailored Facilitation Intervention for improving delivery of 3 pediatric preventive services.

METHODS:
In this cluster-randomized trial, a practice facilitator implemented practice-tailored rapid-cycle feedback/change strategies for improving obesity screening/counseling, lead screening, and dental fluoride varnish application. Thirty practices were randomized to Early or Late Intervention, and outcomes assessed for 16 419 well-child visits. A multidisciplinary team characterized facilitation processes by using comparative case study methods.

RESULTS:
Baseline performance was as follows: for Obesity: 3.5% successful performance in Early and 6.3% in Late practices, P = .74; Lead: 62.2% and 77.8% success, respectively, P = .11; and Fluoride: &lt;0.1% success for all practices. Four months after randomization, performance rose in Early practices, to 82.8% for Obesity, 86.3% for Lead, and 89.1% for Fluoride, all P &lt; .001 for improvement compared with Late practices’ control time. During the full 6-month intervention, care improved versus baseline in all practices, for Obesity for Early practices to 86.5%, and for Late practices 88.9%; for Lead for Early practices to 87.5% and Late practices 94.5%; and for Fluoride, for Early practices to 78.9% and Late practices 81.9%, all P &lt; .001 compared with baseline. Improvements were sustained 2 months after intervention. Successful facilitation involved multidisciplinary support, rapid-cycle problem solving feedback, and ongoing relationship-building, allowing individualizing facilitation approach and intensity based on 3 levels of practice need.

CONCLUSIONS:
Practice-tailored Facilitation Intervention can lead to substantial, simultaneous, and sustained improvements in 3 domains, and holds promise as a broad-based method to advance pediatric preventive care.
Role of Guidelines on Length of Therapy in Chorioamnionitis and Neonatal Sepsis
Authors: Kiser Courtney , Nawab Ursula , McKenna Kristin , Aghai Zubair H. 
Published: May 2014

BACKGROUND AND OBJECTIVE:
Chorioamnionitis (CAM) is a major risk factor for neonatal sepsis. At our institution, neonates exposed to CAM and intrapartum antibiotics are treated with prolonged antimicrobial therapy if laboratory values are abnormal despite a sterile blood culture. Recently, the Committee on the Fetus and Newborn (COFN) recommended a similar strategy for treating neonates exposed to CAM. Our objective was to determine the frequency of abnormal laboratory parameters in term and late-preterm neonates exposed to CAM and evaluate the implication of recent COFN guidelines.

METHODS:
This retrospective data analysis included late-preterm and term neonates exposed to CAM. Laboratory parameters, clinical symptoms and the number of infants treated with prolonged antibiotics were determined.

RESULTS:
A total of 554 infants met the inclusion criteria. Eighty-three infants (14.9%) had an abnormal immature to total neutrophil ratio (&gt;0.2) and 121 infants (22%) had an abnormal C-reactive protein level (&gt;1 mg/dL) at 12 hours of age. A total of 153 infants (27.6%) had an abnormal immature to total neutrophil ratio and/or abnormal C-reactive protein level at 12 hours of age. Only 4 (0.7%) of 554 infants had a positive blood culture result. A total of 134 (24.2%) infants were treated with prolonged antibiotics (112 [20.2%] were treated solely based on abnormal laboratory data). Lumbar puncture was performed in 120 (21.6%) infants.

CONCLUSIONS:
When managed by using a strategy similar to recent COFN guidelines, a large number of term and late-preterm infants exposed to CAM who had sterile blood culture findings were treated with prolonged antibiotic therapy due to abnormal laboratory findings. They were also subjected to additional invasive procedures and had a longer duration of hospitalization.
Health Care Provider-Delivered Adherence Promotion Interventions: A Meta-Analysis
Authors: Wu Yelena P. , Pai Ahna L.H. 
Published: May 2014

BACKGROUND AND OBJECTIVE:Improving medical regimen adherence is essential for maximizing the therapeutic potential of treatments for pediatric chronic illness. Health care providers are uniquely positioned to deliver adherence promotion interventions. However, no studies have summarized the effectiveness of health care provider-delivered adherence interventions. The objective of this study was to describe the effectiveness of health care provider-delivered adherence promotion interventions in improving adherence among children who have chronic illness. Data sources include PubMed, PsycINFO, CINAHL, and Scopus. Studies were included if they were randomized-controlled trials of pediatric interventions aiming to increase adherence to the primary regimen for a chronic illness and at least 1 health care provider delivered the intervention.RESULTS:A total of 35 randomized-controlled studies including 4616 children were included. Greater improvements in adherence were observed immediately after health care provider-delivered interventions (d = 0.49; 95% confidence interval, 0.32 to 0.66) than at longer-term follow-up (d = 0.32; 95% confidence interval, 0.10 to 0.54). Treatment effect sizes differed across the adherence behaviors measured. There was significant heterogeneity in treatment effects; however, no moderators of treatment effectiveness were identified. This meta-analysis focused on the published literature. In addition, the majority of studies involved children who had asthma and younger children.CONCLUSIONS:Health care provider-delivered interventions for children who have chronic illness can be effective in improving adherence. Gains in adherence are highest immediately after intervention. Future interventions and studies should include multiple methods of assessing adherence, include active comparators, and address long-term maintenance of adherence gains.
Respiratory Syncytial Virus Prophylaxis in Down Syndrome: A Prospective Cohort Study
Authors: Yi Hao , Lanctôt Krista L. , Bont Louis , Bloemers Beatrijs L.P. , Weijerman Michel , Broers Chantal , Li Abby , Kiss Alexander , Mitchell Ian , Paes Bosco 
Published: May 2014

BACKGROUND AND OBJECTIVES:
Children with Down syndrome (DS) are at significant risk for respiratory syncytial virus (RSV) infection and related hospitalization. We compared hospitalization rates due to respiratory tract infection in children with DS aged &lt;2 years who prospectively received palivizumab during the RSV season with a previously published, similar untreated DS birth cohort.

METHODS:
A total of 532 children with DS who prospectively received palivizumab were assembled from the prospective Canadian RSV Evaluation Study of Palivizumab registry between 2005 and 2012. The untreated group included 233 children with DS derived from a nationwide Dutch birth cohort from 2003 to 2005. Events during the RSV seasons were counted. Poisson regression analysis was performed to compare incidence rate ratios (95% confidence intervals [CIs]) between groups while controlling for observation length and known risk factors for severe RSV infection.

RESULTS:
In total, 31 (23 untreated, 8 treated) RSV-related hospitalizations were documented. The adjusted risk of RSV-related hospitalizations was higher in untreated subjects than in palivizumab recipients (incidence rate ratio 3.63; 95% CI, 1.52–8.67). The adjusted risk of hospitalization for all respiratory tract infection (147 events; 73 untreated, 74 treated) was similar (incidence rate ratio untreated versus palivizumab 1.11; 95% CI, 0.80–1.55).

CONCLUSIONS:
These results suggest that palivizumab is associated with a 3.6-fold reduction in the incidence rate ratio for RSV-related hospitalization in children with DS during the first 2 years of life. A randomized trial is needed to determine the efficacy of RSV immunoprophylaxis in this specific high-risk patient population.
Growth of Highly (112) Oriented Cu2ZnSnS4 Thin Film on Sapphire Substrate by Radio Frequency Magnetron Sputtering
Authors: Song Ning , Hao Xiaojing , Puthen-Veettil Binesh , Huang Shujuan , Green Martin A 
Published: May 2014

ABSTRACTFor structural investigation, highly (112) oriented tetragonal Cu2ZnSnS4 (CZTS) thin films on hexagonal sapphire (0001) single crystal substrates were obtained by radio frequency (RF) magnetron sputtering. The influences of the deposition parameters, such as substrate temperature (Tsub) and working Ar pressure (PAr) on the chemical composition and structural properties of as deposited CZTS films were investigated. The film sputtered at 500°C has the only orientation of (112), also, it bears the best structural quality with pure CZTS phase and an estimated band gap of 1.51eV.
Molecular Tumor Board: The University of California San Diego Moores Cancer Center Experience
Authors: Schwaederle Maria , Parker Barbara A. , Schwab Richard B. , Fanta Paul T. , Boles Sarah G. , Daniels Gregory A. , Bazhenova Lyudmila A. , Subramanian Rupa , Coutinho Alice C. , Ojeda-Fournier Haydee , Datnow Brian , Webster Nicholas J. , Lippman Scott M. , Kurzrock Razelle 
Published: May 2014

Abstract

Objective.
DNA sequencing tests are enabling physicians to interrogate the molecular profiles of patients’ tumors, but most oncologists have not been trained in advanced genomics. We initiated a molecular tumor board to provide expert multidisciplinary input for these patients.

Materials and Methods.
A team that included clinicians, basic scientists, geneticists, and bioinformatics/pathway scientists with expertise in various cancer types attended. Molecular tests were performed in a Clinical Laboratory Improvement Amendments environment.

Results.
Patients (n = 34, since December 2012) had received a median of three prior therapies. The median time from physician order to receipt of molecular diagnostic test results was 27 days (range: 14–77 days). Patients had a median of 4 molecular abnormalities (range: 1–14 abnormalities) found by next-generation sequencing (182- or 236-gene panels). Seventy-four genes were involved, with 123 distinct abnormalities. Importantly, no two patients had the same aberrations, and 107 distinct abnormalities were seen only once. Among the 11 evaluable patients whose treatment had been informed by molecular diagnostics, 3 achieved partial responses (progression-free survival of 3.4 months, ≥6.5 months, and 7.6 months). The most common reasons for being unable to act on the molecular diagnostic results were that patients were ineligible for or could not travel to an appropriately targeted clinical trial and/or that insurance would not cover the cognate agents.

Conclusion.
Genomic sequencing is revealing complex molecular profiles that differ by patient. Multidisciplinary molecular tumor boards may help optimize management. Barriers to personalized therapy include access to appropriately targeted drugs.
Costs of Allogeneic Hematopoietic Cell Transplantation Using Reduced Intensity Conditioning Regimens
Authors: Khera Nandita , Emmert Amy , Storer Barry E. , Sandmaier Brenda M. , Alyea Edwin P. , Lee Stephanie J. 
Published: May 2014

Abstract
Reduced intensity conditioning (RIC) regimens have allowed older patients and those with comorbidities to receive hematopoietic cell transplantation (HCT). We analyzed medical costs from the beginning of conditioning to 100 days after HCT for 484 patients and up to 2 years for 311 patients who underwent a RIC HCT at two institutions from January 2008 to December 2010. Multiple linear regression was used to analyze the association between clinical variables, center effect, and costs. Patient and transplant characteristics were comparable between the sites, although differences were seen in pretransplant performance scores. Significant predictors for lower costs for the first 100 days included a diagnosis of lymphoma/myeloma and use of human leukocyte antigen-matched related donors. Grade II-IV acute graft-versus-host disease (GVHD) was associated with higher costs. The overall short-term costs between the two institutions were comparable when adjusted for clinical variables (p = .43). Late costs between 100 days and 2 years after HCT were available for one cohort (n = 311); median costs during this period were $39,000 and accounted for 39% of costs during the first 2 years. Late costs were not associated with any pretransplant variables, but were higher with extensive chronic GVHD and death. After adjustment for clinical characteristics, the overall costs of the RIC transplants were similar between the two institutions despite different management approaches (inpatient vs. outpatient conditioning) and accounting methodologies. Use of unrelated/alternative donors, transplant for diseases other than lymphoma or myeloma, and acute GVHD were predictors for higher early costs, and extensive chronic GVHD and death were associated with higher late costs.