bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Cilostazol on Right Heart Function and Pulmonary Pressure
Authors: Sahin Muslum , Alizade Elnur , Pala Selcuk , Alici Gokhan , Ozkan Birol , Akgun Taylan , Emiroglu Yunus , Demir Serdar , Yazicioglu Mehmet V. , Turkmen Mehmet M. 
Published: August 2013

SummaryIntroductionCilostazol is a PDE3 inhibitor and used to treat peripheral arterial disease. There are few reports on the influence of cilostazol on heart.AimsThe aim of this study was to assess this effect on right ventricular function and pulmonary artery pressure.MethodsForty patients with normal left and right ventricular ejection fraction and mild or moderate pulmonary artery hypertension were enrolled in the study. Right ventricular function was assessed by tricuspid annular plane systolic excursion (TAPSE), fractional area change (FAC), tissue Doppler imaging (TDI), and two‐dimensional speckle‐tracking echocardiography (2D‐STE) before and after oral administration of cilostazol. Also pulmonary artery pressure assessed before and after administration of cilostazol.ResultsAfter cilostazol administration, there were significant increases in the TAPSE (1.9 ± 0.3 cm vs. 2.2 ± 0.3 cm, P < 0.001). Peak longitudinal strain (−18.7 ± 4.5% vs. −21.3 ± 3.7%, P = 0.001), isovolumetric acceleration (IVA) (176.6 ± 62.7 cm/sec2 vs. 200.6 ± 61.9 cm/sec2, P = 0.025), right ventricular FAC increased significantly (37.6 ± 8.0% vs. 41.5 ± 8.9%, P < 0.001). Pulmonary artery pressure decreased significantly (39.9 ± 7.9 vs. 36.6 ± 5.5 mmHg, P = 0.001) after cilostazol administration.ConclusionOur study demonstrated that cilostazol improved right ventricular systolic function and reduced pulmonary artery pressure.
Registry of gastric cancer treatment evaluation (REGATE): II treatment practice
Authors: Ter‐Ovanesov Mikhail , Yalcin Suayib , Zalcberg John , Hitier Simon , Bang Yung‐Jue , Wu Chew‐Wun , Roth Arnaud 
Published: August 2013

AbstractAimsThe objective of the registry of gastric cancer treatment evaluation (REGATE) study was to evaluate approaches to gastric cancer treatment in different geographical regions.MethodsREGATE enrolled patients with newly diagnosed gastric cancer at any stage of the disease from the Asia–Pacific region, Europe, the Indian subcontinent, Latin America and North Africa between 2004 and 2008.ResultsAmong 9965 patients, 69% received surgery, 40% palliative care, 29% adjuvant therapy and 2% neoadjuvant therapy; 15% received no treatment. Combination treatment (mostly surgery/adjuvant) was used in one‐third of patients. Overall, 90% received chemotherapy (mostly fluoropyrimidine/platinum combinations but with marked geographical variation) and 21% received radiotherapy. Curative surgery alone was used most frequently for stages 0–II cancers and was employed more often in Europe (55%) and the Asia–Pacific (48%) than in other regions (27–35%). Asia–Pacific and Indian subcontinent patients were more likely to have a distal subtotal gastrectomy and less likely to undergo total gastrectomy than patients in other regions. Lymph node D2 dissection was favored in the Asia–Pacific, Europe and Latin America, whereas D1 dissection was used more in the Indian subcontinent and North Africa.ConclusionThese data showing geographical differences in the approaches to gastric cancer treatment may promote the optimization of the management of gastric cancer globally.
Why do some cancer patients receiving chemotherapy choose to take complementary and alternative medicines and what are the risks?
Authors: Smith Peter J , Clavarino Alexandra , Long Jeremy , Steadman Kathryn J 
Published: August 2013

AbstractComplementary and alternative medicine (CAM) cover a broad and diverse group of treatments and products that do not tend to be widely used by conventional healthcare professions.CAMthat is systemically absorbed is the most likely to interfere with concurrent chemotherapy and potentially cause harm to cancer patients. Patients receiving chemotherapy may be consumingCAMto treat cancer, to lessen chemotherapy side effects, for symptom management, or to treat conditions unrelated to their cancer. A small proportion of cancer patients decide to useCAMalone to treat cancer and delay conventional treatment. Cancer patients may be influenced in theirCAMdecision‐making by others: practitioners, family, friends, spouse and even casual acquaintances met in waiting rooms and support groups. This influence may range from encouraging and supporting the patient's decision through to making the decisions for the patient. When tested in rigorous clinical trials, noCAMcancer treatments alone have shown benefit beyond placebo. With the exception of ginger to treat chemotherapy‐induced nausea, there is no compelling evidence overriding risk to take complementary medicines for supportive care during chemotherapy treatment. There is, however, established evidence to use mind–body complementary therapies for supportive care during chemotherapy treatment.
The effect of bariatric surgery on psychiatric course among patients with bipolar disorder
Authors: Ahmed Ameena T , Warton E Margaret , Schaefer Catherine A , Shen Ling , McIntyre Roger S 
Published: August 2013

ObjectiveBariatric surgery is the most effective therapy for severe obesity. People with bipolar disorder have increased risk of obesity, yet are sometimes considered ineligible for bariatric surgery due to their bipolar disorder diagnosis. This study aimed to determine if bariatric surgery alters psychiatric course among stable patients with bipolar disorder.MethodsA matched cohort study (2006–2009) with mean follow‐up of 2.17 years was conducted within Kaiser Permanente Northern California, a group practice integrated health services delivery organization that provides medical and psychiatric care to 3.3 million people. Participants were 144 severely obese patients with bipolar disorder who underwent bariatric surgery, and 1,440 control patients with bipolar disorder, matched for gender, medical center, and contemporaneous health plan membership. Controls met referral criteria for bariatric surgery. Hazard ratio for psychiatric hospitalization, and change in rate of outpatient psychiatric utilization from baseline to Years 1 and 2, were compared between groups.ResultsA total of 13 bariatric surgery patients (9.0%) and 153 unexposed to surgery (10.6%) had psychiatric hospitalization during follow‐up. In multivariate Cox models adjusting for potential confounding factors, the hazard ratio of psychiatric hospitalization associated with bariatric surgery was 1.03 [95% confidence interval (CI): 0.83–1.23]. In fully saturated multivariate general linear models, change in outpatient psychiatric utilization was not significantly different for surgery patients versus controls, from baseline to Year 1 (−0.4 visits/year, 95% CI: −0.5 to 0.4) or baseline to Year 2 (0.4 visits/year, 95% CI: −0.1 to 1.0).ConclusionsBariatric surgery did not affect psychiatric course among stable patients with bipolar disorder. The results of this study suggest that patients with bipolar disorder who have been evaluated as stable can be considered for bariatric surgery.
Tilted and Short Implants Supporting Fixed Prosthesis in an Atrophic Maxilla: A 3D‐FEA Biomechanical Evaluation
Authors: Almeida Erika O. , Rocha Eduardo P. , Júnior Amilcar C. Freitas , Anchieta Rodolfo B. , Poveda Ronald , Gupta Nikhil , Coelho Paulo G. 
Published: August 2013

AbstractPurposeThis study compared the biomechanical behavior of tilted long implant and vertical short implants to support fixed prosthesis in an atrophic maxilla.Materials and MethodsThe maxilla model was built based on a tomographic image of the patient. Implant models were based on micro‐computer tomography imaging of implants. The different configurations considered were M4S, four vertical anterior implants; M4T, two mesial vertical implants and two distal tilted (45°) implants in the anterior region of the maxilla; and M6S, four vertical anterior implants and two vertical posterior implants. Numerical simulation was carried out under bilateral 150 N loads applied in the cantilever region in axial (L1) and oblique (45°) (L2) direction. Bone was analyzed using the maximum and minimum principal stress (σmax and σmin), and von Mises stress (σvM) assessments. Implants were analyzed using the σvM.ResultsThe higher σmax was observed at: M4T, followed by M6S/L1, M6S/L2, M4S/L2, and M4S/L1 and the higher σvM: M4T/L1, M4T/L2 and M4S/L2, M6S/L2, M4S/L1, and M6S/L1.ConclusionsThe presence of distal tilted (all‐on‐four) and distal short implants (all‐on‐six) resulted in higher stresses in both situations in the maxillary bone in comparison to the presence of vertical implants (all‐on‐four).
Global Analysis of Anthropogenic Debris Ingestion by Sea Turtles
Authors: SCHUYLER QAMAR , HARDESTY BRITTA DENISE , WILCOX CHRIS , TOWNSEND KATHY 
Published: August 2013

AbstractIngestion of marine debris can have lethal and sublethal effects on sea turtles and other wildlife. Although researchers have reported on ingestion of anthropogenic debris by marine turtles and implied incidences of debris ingestion have increased over time, there has not been a global synthesis of the phenomenon since 1985. Thus, we analyzed 37 studies published from 1985 to 2012 that report on data collected from before 1900 through 2011. Specifically, we investigated whether ingestion prevalence has changed over time, what types of debris are most commonly ingested, the geographic distribution of debris ingestion by marine turtles relative to global debris distribution, and which species and life‐history stages are most likely to ingest debris. The probability of green (Chelonia mydas) and leatherback turtles (Dermochelys coriacea) ingesting debris increased significantly over time, and plastic was the most commonly ingested debris. Turtles in nearly all regions studied ingest debris, but the probability of ingestion was not related to modeled debris densities. Furthermore, smaller, oceanic‐stage turtles were more likely to ingest debris than coastal foragers, whereas carnivorous species were less likely to ingest debris than herbivores or gelatinovores. Our results indicate oceanic leatherback turtles and green turtles are at the greatest risk of both lethal and sublethal effects from ingested marine debris. To reduce this risk, anthropogenic debris must be managed at a global level.Análisis Global de la Ingesta de Residuos Antropogénicos por Tortugas Marinas
Is It What You Do, or When You Do It? The Roles of Contingency and Similarity in Pro‐Social Effects of Imitation
Authors: Catmur Caroline , Heyes Cecilia 
Published: August 2013

AbstractBeing imitated has a wide range of pro‐social effects, but it is not clear how these effects are mediated. Naturalistic studies of the effects of being imitated have not established whether pro‐social outcomes are due to the similarity and/or the contingency between the movements performed by the actor and those of the imitator. Similarity is often assumed to be the active ingredient, but we hypothesized that contingency might also be important, as it produces positive affect in infants and can be detected by phylogenetically ancient mechanisms of associative learning. We manipulated similarity and contingency between performed and observed actions in a computerized task. Similarity had no positive effects; however, contingency resulted in greater enjoyment of the task, reported closeness to others, and helping behavior. These results suggest that the pro‐social effects of being imitated may rely on associative mechanisms.
Parasitism of a pollinator fig wasp: mortalities are higher in figs with more pollinators, but are not related to local densities of figs
Authors: SULEMAN NAZIA , RAJA SHAZIA , COMPTON STEPHEN G. 
Published: August 2013

Fig trees (Ficus) and their species‐specific pollinators (Agaonidae) represent a remarkable example of a coevolved mutualism. A number of non‐pollinating fig wasps (gallers and parasitoids,NPFW) are also an integral part of the mutualism, but have a negative impact on the reproductive success of the mutualists. MostNPFWbelong to subfamilies only associated with figs and clearly have a long association with the plants and their pollinators.In the present study, the costs imposed by an undescribed parasitoidSycoscaptersp. on its host pollinatorKradibia (=Liporrhopalum) tentacularisof a dioecious fig treeFicus montanamaintained under glasshouse conditions are described.It was asked whether pollinator numbers and sex ratios are changed by the presence or absence of parasitoids within individual figs. The effect of fig densities on parasitism rates at two spatial scales and within the general glasshouse population was also recorded. Parasitoid aggregation in relation to pollinator densities inside figs was also examined.Sycoscaptersp. significantly reduced the numbers of pollinators emerging from the figs, but host sex ratios were not distorted. The parasitoid showed host density independence at both spatial scales of fig densities, but targeted individual figs that contained higher initial densities of pollinators.
The ecology of differences: assessing community assembly with trait and evolutionary distances
Authors: Cadotte Marc , Albert Cecile H. , Walker Steve C. 
Published: August 2013

AbstractSpecies enter and persist in local communities because of their ecological fit to local conditions, and recently, ecologists have moved from measuring diversity as species richness and evenness, to using measures that reflect species ecological differences. There are two principal approaches for quantifying species ecological differences: functional (trait‐based) and phylogenetic pairwise distances between species. Both approaches have produced new ecological insights, yet at the same time methodological issues and assumptions limit them. Traits and phylogeny may provide different, and perhaps complementary, information about species' differences. To adequately test assembly hypotheses, a framework integrating the information provided by traits and phylogenies is required. We propose an intuitive measure for combining functional and phylogenetic pairwise distances, which provides a useful way to assess how functional and phylogenetic distances contribute to understanding patterns of community assembly. Here, we show that both traits and phylogeny inform community assembly patterns in alpine plant communities across an elevation gradient, because they represent complementary information. Differences in historical selection pressures have produced variation in the strength of the trait‐phylogeny correlation, and as such, integrating traits and phylogeny can enhance the ability to detect assembly patterns across habitats or environmental gradients.
Adaptive evolution of a generalist parasitoid: implications for the effectiveness of biological control agents
Authors: Zepeda‐Paulo Francisca A. , Ortiz‐Martínez Sebastián A. , Figueroa Christian C. , Lavandero Blas 
Published: August 2013

AbstractThe use of alternative hosts imposes divergent selection pressures on parasitoid populations. In response to selective pressures, these populations may follow different evolutionary trajectories. Divergent natural selection could promote local host adaptation in populations, translating into direct benefits for biological control, thereby increasing their effectiveness on the target host. Alternatively, adaptive phenotypic plasticity could be favored over local adaptation in temporal and spatially heterogeneous environments. We investigated the existence of local host adaptation in Aphidius ervi, an important biological control agent, by examining different traits related to infectivity (preference) and virulence (a proxy of parasitoid fitness) on different aphid‐host species. The results showed significant differences in parasitoid infectivity on their natal host compared with the non‐natal hosts. However, parasitoids showed a similar high fitness on both natal and non‐natal hosts, thus supporting a lack of host adaptation in these introduced parasitoid populations. Our results highlight the role of phenotypic plasticity in fitness‐related traits of parasitoids, enabling them to maximize fitness on alternative hosts. This could be used to increase the effectiveness of biological control. In addition, A. ervi females showed significant differences in infectivity and virulence across the tested host range, thus suggesting a possible host phylogeny effect for those traits.
How do people interpret information about colorectal cancer screening: observations from a think‐aloud study
Authors: Smith Samuel G. , Vart Gemma , Wolf Michael S. , Obichere Austin , Baker Helen J. , Raine Rosalind , Wardle Jane , von Wagner Christian 
Published: August 2013

AbstractBackgroundThe English NHS Bowel Cancer Screening Programme biennially invites individuals aged 60–74 to participate in screening. The booklet, ‘Bowel Cancer Screening: The Facts' accompanies this invitation. Its primary aim is to inform potential participants about the aims, advantages and disadvantages of colorectal cancer screening.ObjectiveTo provide detailed commentary on how individuals process the information contained within ‘The Facts’ booklet.Design, setting and participantsThis study comprised of 18 interviews with individuals aged 45–60 and used a ‘think‐aloud’ paradigm in which participants read aloud the booklet. Participant utterances (verbal statements made in response to researcher‐led prompts) were transcribed and analysed using a combination of content and thematic analysis.ResultsA total of 776 coded utterances were analysed (mean = 43.1 per person; range = 8–95). While overall comprehension was satisfactory, several problem areas were identified such as the use of complex unfamiliar terminology and the presentation of numerical information. Specific sections such as colonoscopy risk information evoked negative emotional responses. Participants made several suggestions for ways in which comprehension might be improved.ConclusionPublic perceptions of the NHS Bowel Cancer Screening Programme information materials indicated that specific aspects of the booklet were difficult to process. These materials may be an appropriate target to improve public understanding of the aims, benefits and disadvantages of colorectal cancer screening. These findings will contribute to a broader NIHR‐funded project that aims to design a supplementary ‘gist‐based’ information leaflet suitable for low literacy populations.
Consumers' acceptance and quality stability of olive oil flavoured with essential oils of different oregano species
Authors: Asensio Claudia M. , Nepote Valeria , Grosso Nelson R. 
Published: August 2013

SummaryThe objective of this study was to evaluate chemical and physical stability and consumers' acceptance of olive oil flavoured with oregano essential oils (EOs; Compacto, Cordobes, Criollo and Mendocino). Samples of olive oil were added with 0.05% EO and stored in dark (D) and light (L) conditions for 126 days. Samples with oregano EO had lower lipid oxidation indicator values [K232, K269, peroxide value (PV) and anisidine value], especially in darkness. Olive oil with Cordobes EO in D had the lowest PV (18.71 meqO2 kg−1). Using prediction equations, 20 meqO2 kg−1 PV in olive oil should be reached in 34 days in L control sample and in 126 days in the Cordobes EO sample in darkness. Samples with Cordobes and Criollo EOs in darkness had the highest chlorophyll content after 126 days (2.91 and 2.88 mg kg−1, respectively). Sensory analysis showed that oregano EO addition in olive oil was detected by panellists in discriminative test and affected consumer acceptance.
Influence of the addition of lupin sourdough with different lactobacilli on dough properties and bread quality
Authors: Bartkiene Elena , Schleining Gerhard , Rekstyte Toma , Krungleviciute Vita , Juodeikiene Grazina , Vaiciulyte‐Funk Lina , Maknickiene Zita 
Published: August 2013

SummaryThe aim of this research was to study the effects of solid‐state fermentation (SSF) with Lactobacillus sakei, Pediococcus pentosaceus and P. acidilactici on lupine sourdough parameters and lupine sourdough influence on the physical dough properties and wheat bread quality. The results showed that lactic acid bacteria (LAB) significantly reduced the pH and increased total titratable acidity (TTA) of SSF lupine. The highest protease activity in lupine is excreted by L. sakei (187.1 ± 8.6 PU g−1), and the highest amylase activity, by P. pentosaceus (155.8 ± 7.5 AU g−1). Lupine sourdough has a significant effect on the rheological properties of doughs, which affect the baking characteristics of the final product. In conclusion, it can be said that L. sakei, P. pentosaceus and P. acidilactici could be used for lupine SSF, and the addition of up to the 10% SSF lupine products increases the wheat–lupine bread quality.
Study of different nectarine cultivars and their suitability for fresh‐cut processing
Authors: Nogales‐Delgado Sergio , Fuentes‐Pérez María del Carmen , Ayuso‐Yuste Concepción , Bohoyo‐Gil Diego 
Published: August 2013

SummaryNectarine [Prunus persica (L.) Batsch] is a sought‐after fruit due to its properties. In addition, minimally processed produces are more and more accepted by consumers. Four nectarine cultivars (‘Early Top’, ‘Nectaprima’, ‘Big Top’ and ‘Venus’) were selected to study their suitability for minimal processing. Samples were processed in a clean room at 8 °C, washed them in water (4 °C) and stored at 4 °C in modified atmosphere packaging. The samples were analysed at 0, 3, 6 and 9 days of storage, and quality parameters as well as functional compounds (polyphenols and polyphenol oxidase activity) were studied. Principal component analysis (PCA) was carried out to assess the relationship between nectarine cultivars and determined parameters. In conclusion, ‘Early Top’ and ‘Nectaprima’ cultivars showed the best quality results and therefore a promising suitability for fresh‐cut processing. Nevertheless, the remaining cultivars should not be ruled out due to their functional content, advising additional conservation treatments for them.
Optimisation of analytical methods for the characterisation of oranges, clementines and citrus hybrids cultivated in Spain on the basis of their composition in ascorbic acid, citric acid and major sugars
Authors: Carballo Silvia , Zingarello Fabrizio A. , Maestre Salvador E. , Todolí José L. , Prats M. Soledad 
Published: August 2013

SummaryThree HPLC methods were optimised for the determination of citric acid, succinic acid and ascorbic acid using a photodiode array detector and fructose, glucose and sucrose using a refractive index in twenty eight citrus juices. The analysis was completed in <16 min. Two different harvests were taken into account for this study. For the season 2011, ascorbic acid content was comprised between 19.4 and 59 mg vitamin C/100 mL; meanwhile for the season 2012, the content was slightly higher for most of the samples ranging from 33.5 to 85.3 mg vitamin C/100 mL. Moreover, the citric acid content in orange juices ranged between 9.7 and 15.1 g L−1, while for clementines the content was clearly lower (i.e. from 3.5 to 8.4 g L−1). However, clementines showed the highest sucrose content with values near to 6 g/100 mL. Finally, a cluster analysis was applied to establish a classification of the citrus species.