bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antioxidant and antibacterial effects of a new macrocyclic bis(bibenzyl) ether from Combretum molle (Combretaceae)
Authors: Yakai Fawai , Dawe Amadou , Manshuk Ibrayeva , Taira Vincent , Wangso Albert , Fanta Angele , Doudja Chantal , Loura Benoit 
Published: June 2024

Abstract
A new compound, combrebisbibenzyl (1) as well as two sterols including stigmasterol (2) and 3-O-β-D-glucopyranoside of β-sitosterol (3) and seven triterpenoids namely mollic acid (4), oleanolic acid (5), ursolic acid (6), arjunglucoside I (7), arjungenin (8), bellericagenin B (9) and combregenin (10) were isolated from the root of Combretum molle. Compounds 1, 7 and 9, AcOEt and MeOH extracts exhibited moderate antioxidant activity with an IC50 value of 179.32, 185.21, 195.11 197.41 and 170.21 μg/mL, respectively, for reactive oxygen species inhibition and, inhibition percent value of 57.23, 64.52, 53.55, 67.42 and 65.04, respectively, for DPPH free-radical scavenging. The E. MeOH presented a moderate antibacterial activity against Staphylococcus aureus with DIZs value of 10.1 ± 0.2 from 800 μg/mL while the others tested strains were not sensitive. However, most of the tested bacteria, (S. aureus, Escherichia coli and Salmonella typhimurium) were moderately sensitive to E. AcOEt from 800 μg/mL with DIZs value of 8.2 ± 0.1. From the E. AcOEt, five of the isolated compounds were tested against four bacteria strains using the disc-dilusion method. The results showed that compound 1 and 2 exhibited very good antibacterial activity against all the tested bacteria at the concentration of 30 μg/mL with respective DIZ value of 22.2 and 25.4 for E. coli, 20.2 and 30.2 for S. typhimurium, 22.3 and 23.1 for S. aureus and, 22.1 and 24.1 for Streptococcus faecalis. This antibacterial activity significantly depends on the concentration.
Supramolecular hydrogels for sustained extracellular vesicle delivery
Authors: Patel Neil , Avery Elijah , Chung Eun Ji 
Published: June 2024

AbstractExtracellular vesicles (EVs) have been explored as promising drug delivery platforms and cell-free therapies for a range of diseases. Despite their therapeutic potential, challenges persist in achieving sustained EV delivery. Here, we integrate EVs into a supramolecular and injectable hydrogel-based drug delivery system based on dodecyl- or octadecyl-modified hydroxypropyl methylcellulose (HPMC-C12 or -C18) that form non-covalent crosslinks with liposomes. Hydrogel mechanics and EV-release kinetics were tunable by varying liposome concentrations. Using mesenchymal stem cell-derived EVs (MSC-EVs), we confirm effective, hydrogel-mediated sustained EV delivery and uptake and a ~ 20% greater anti-inflammatory response in pathogenic vascular smooth muscle cells than bolus EV-only treatment.
Graphical abstract
The French Connection
Authors: Wilson C Anne 
Published: June 2024

C. Anne Wilson, author of the well-known Food and Drink in Britain (Constable, 1973), works at the Brotherton Library of the University of Leeds, which has a particularly fine collection of early cookery books. She has been doing research into the French influence on English cookery from the fourteenth century onwards. This first part of her article takes us up to the end of the sixteenth century. We look forward to publishing before long the second part, which will cover the seventeenth and eighteenth centuries in England, and perhaps something on the sixteenth century Scottish connection.
Pengaruh Rasio Sari Kulit Kopi Arabika Dan Konsentrasi CMC (Carboxyl methyl cellulose) Berbeda Terhadap Aktivitas Antioksidan Dan Organoleptik Selai Cascara
Authors: Romauli Nauas Domu Marihot , Nurminah Mimi , Siahaan Felinda Tria Kasih 
Published: June 2024

Abstrak. Penelitian ini tentang selai yang terbuat dari bahan dasar kulit kopi arabika dengan rasio air yang berbeda untuk menghasilkan sari dan penambahan konsentrasi CMC (carboxy methyl cellulose). Penelitian ini bertujuan mengetahui pengaruh rasio air dengan kulit kopi arabika serta pengaruh penambahan konsentrasi CMC terhadap sifat fisik dan kimia. Rancangan penelitian yang digunakan yaitu Rancangan Acak Lengkap (RAL) dengan dua faktor. Faktor pertama yaitu rasio air dengan kulit kopi (R) terdiri dari 3 taraf 1:1, 2:1, 3:1. Faktor kedua yaitu konsentrasi CMC (carboxyl methyl cellulose) (K) terdiri dari 4 taraf 0,5%, 0,75%, 1%, 1,25% dengan pengulangan 3 kali. Analisis yang dilakukan adalah aktivitas antioksidan, uji daya oles dan uji organoleptik (warna, rasa aroma, penerimaan umum). Hasil penelitian menunjukkan rasio air yang semakin tinggi menurunkan tingkat persentase antioksidan pada kulit kopi arabika, konsentrasi CMC yang semakin banyak menyebabkan selai cascara sulit di oles pada permukaan roti. Berdasarkan pengujian organoleptik warna, rasa, aroma dan penerimaan umum memiliki rerata nilai 6 yaitu suka dan selai cascara dapat diterima oleh panelis. The Effect of Different Ratios of Arabica Coffee Skin Juice and CMC (Carboxyl methyl cellulose) Concentrations on the Antioxidant and Organoleptic Activities of Cascara Jam Abstract. This research was about jam made from Arabica coffee pulp with different water ratios to produce juice and the addition of CMC (carboxy methyl cellulose) concentration. This research aims to determine the effect of the ratio of water to Arabica coffee skins and the effect of adding CMC concentration on physical and chemical properties. The research design used was a Completely Randomized Design (CRD) with two factors. The first factor, namely the ratio of water to coffee pulp (R), consists of three levels: 1:1, 2:1, 3:1. The second factor is the concentration of CMC (carboxyl methyl cellulose) (K), consisting of 4 levels of 0.5%, 0.75%, 1%, 1.25% with repetition three times. The analyses carried out were antioxidant activity, spreadability test, and organoleptic test (color, taste, aroma, general acceptability). The results of the research show that a higher water ratio reduces the percentage level of antioxidants in Arabica coffee pulp, the water ratio in different CMC concentration gave significantly different effect (sig0.05) on the antioxidant value. The higher concentration of CMC makes cascara jam difficult to spread on the surface of the bread. The use of 1.25% CMC gave the lowest spreadibility, meanwhile the use of 0.5% and 0.75% gave spreadibility of cascara jam near 6 scale. Based on organoleptic testing of color, taste, aroma, and general acceptance, it has an average score of 6, and cascara jam can be accepted by the panelists.
Inferior humeral head subluxation after acute humeral shaft fractures
Authors: Gass Henry M. , Seilern Jesse , Cantu Nicolas , Jones Corey A. , Moore Thomas J. 
Published: June 2024

Background: Inferior humeral head subluxation (IHHS) is an abnormal inferior translation of the humeral head with respect to the glenoid. While well described for proximal humerus fractures there is little literature regarding IHHS in humeral shaft fractures and the impact of IHHS on fracture healing during non-operative treatment. This study characterized the prevalence and impact of IHHS among patients with acute humeral shaft fractures at a large urban trauma center.
Methods: This retrospective analysis included 62 patients treated conservatively for acute humeral shaft fractures at a single level I trauma center from 2018-2021. Occurrence of IHHS in millimeters was measured radiographically as the distance between the inferior glenoid edge and humeral anatomic neck, a distance greater than 10 mm was considered positive. Demographic data, injury mechanism, AO/OTA fracture classification, risk factors (history of stroke, smoking, diabetes mellitus, radial nerve palsy on presentation, any neurovascular disorder), and failure of conservative management (surgical fixation after a 90-day trial) was recorded. Statistical analyses were performed to evaluate association between risk factors, treatment outcome, and IHHS resolution.
Results: At an average follow-up of 18 weeks, IHHS was noted at any time point in 32.3% patients. All cases of IHHS resolved without formal treatment. No factors were significantly associated with the occurrence of IHHS. 17.7% patients failed conservative treatment, only three had IHHS.
Conclusions: Although IHHS occurred in one third of the study population, it was not significantly correlated with failed conservative management or the need for surgical intervention. This study expands the scope of this phenomenon to include humeral shaft fractures.
Effectiveness of abduction orthoses in the management of developmental hip dysplasia: a comparative retrospective study
Authors: Enríquez Josselyn N. V. , Vera Mateo D. F. , Durán Juan C. P. , Vera Andres G. F. 
Published: June 2024

Background: Developmental dysplasia of the hip (DDH) is a disorder marked by abnormal hip alignment or structure, often calling for orthopedic treatment. The purpose of this research was to compare the Aro and Milgram splints, two types of orthopedic splints, for use in treating diabetic foot disease.
Methods: Between three and four months of age, 53 patients were identified with hip dysplasia in a retrospective observational analysis. Beginning at six months of age, patients received treatment with either the aro splint or the milgram splint. At six and twelve months after the start of therapy, radiographic measures of the acetabular angle were made. Statistical analysis was done to assess the efficacy of the two splints and compare treatment results.
Results: The aro and milgram splints both reduced acetabular angles, and there was no discernible difference between them in terms of reaching the ideal angle. Most patients needed to get therapy for around five months to achieve the ideal angle. With both splints, there were notable decreases in acetabular angles, even though some patients were unable to achieve this angle. Eighty-one percent of the patients were female, which is consistent with established DDH demographics.
Conclusions: These findings suggest that both splints can lower acetabular angles and treat hip dysplasia in DDH patients. Both the aro and milgram splints lower acetabular angles and reverse hip dysplasia in DDH patients. Using either splint may enhance hip stability and function. Both splints are effective DDH therapeutic alternatives, according to these results.
The Efficacy of Mediterranean Diet for Erectile Dysfunction in Diabetes Mellitus Patients: A Narrative Review
Authors: Atmaja Maxwell , Purnama Michael , Kevin Kevin , Aslama Fathiy Zakaria , Rizkiliano Ibrahim Hanif , Sudana Nathan Kunta , I’tishom Reny 
Published: June 2024

Background : Male infertility affects millions globally, with 12-15% of Indonesian couples facing conception challenges, 50% of which are attributed to male factors. Despite extensive research, 70% of male infertility cases remain idiopathic. Diabetes, a prominent factor in male infertility, affects 9.3% of the global population, with projections estimating 700 million cases by 2045. Recent studies suggest the Mediterranean diet positively impacts semen parameters, particularly in diabetic individuals. This review aims to explore the Mediterranean diet's effects on fertility in male diabetic patients.
Reviews : The literature review employed three databases, focusing on in-vitro, in-vivo, pre-clinical, and clinical studies from 2014-2024. Diabetes, a chronic disease characterized by abnormal blood sugar levels, affects insulin production or effectiveness, leading to complications if left uncontrolled. Erectile dysfunction (ED), prevalent in diabetic men, is attributed to nerve and blood vessel damage from high blood sugar levels. Treatments for ED include PDE5 inhibitors, but alternative plant-based therapies are being explored. Platelet-rich plasma (PRP) has shown promise in animal studies but lacks human trial data. The Mediterranean diet, rich in plant-based foods and healthy fats, may help prevent sexual function deterioration in diabetic individuals. Comprehensive nutrition education and government efforts are crucial in promoting healthy lifestyles and ensuring access to fresh foods.
Summary : In conclusion, the Mediterranean diet shows promise as a dietary intervention for improving male fertility in diabetic populations. Further research is warranted to confirm these findings and to explore the mechanisms underlying the effects of the Mediterranean diet on male fertility.
Physicochemical Characterization and Antioxidant Activity of Jara Honey Produced in Western Georgia
Authors: Abashidze Nona , Japaridze Indira , Vanidze Maia , Khakhutaishvili Meri , Kharadze Maia , Qarcivadze Inga , Davitadze Ruslani , Kalandia Aleko 
Published: June 2024

The purpose of this research article was to study the physicochemical characteristics of semi-wild Jhar honey grown in Western Georgia. Jara honey is produced in the alpine and sub-alpine forest zone of high mountain Adjara, which is distinguished by the variety of honey plants [1]. The physicochemical characteristics were examined concerning the Alimemtarius Code and EU regulations: moisture content, total carbohydrate, free acidity, pH , electrical conductivity, microelements (Li, Na, K, Mg, Ca), color, total phenols, total phenolic acids, total flavonoids, proline, diastase activity, protein and microscopic study of pollens. Using the UPLC-MSB method, grayanotoxin-III was identified in the semi-wild Jara honey samples. The findings demonstrated that honey has significant concentrations of phenols, phenolic acids, and flavonoids. A directly proportional relationship was established between the quantitative content of phenolic compounds and the antioxidant activity of honey. This article is the first study of the characteristics of Jara honey produced in Western Georgia.
Aseptic Revision Total Hip Arthroplasty Using Modular Fluted Tapered Stems
Authors: Carender Christopher N. , Larson Dirk R. , Trousdale Robert T. , Lewallen David G. , Berry Daniel J. , Abdel Matthew P. 
Published: June 2024

Background:
Modular fluted tapered (MFT) femoral components are frequently utilized in aseptic revision total hip arthroplasties (THAs). However, long-term follow-up has been limited. The purpose of this study was to update our prior series at long-term follow-up, with specific emphasis on implant survivorship, radiographic results, and complications in a large cohort of aseptic revision THAs using MFT stems.

Methods:
We retrospectively identified 515 aseptic femoral revisions performed with 2 MFT stem designs in the total joint registry of a single tertiary care academic institution from 1999 to 2013. Serial radiographs were reviewed for subsidence of >5 mm. The mean follow-up (and standard deviation) was 10 ± 5 years (range, 2 to 21 years). A competing risk model accounting for death was utilized.

Results:
The 15-year cumulative incidence of any revision was 12%. There were 57 revisions, 27 of which involved revision of the fluted tapered component (FTC). Dislocation (n = 19), periprosthetic joint infection (n = 15), and aseptic loosening of the FTC (n = 11) were the most common reasons for revision. The 15-year cumulative incidence of any reoperation was 16%. The 15-year cumulative incidences were 6% for any FTC revision and 2% for FTC revision for aseptic loosening. Stem subsidence of >5 mm occurred in 2% of unrevised cases, and all but 1 stem was stable at the most recent follow-up.

Conclusions:
This large series of MFT stems used in aseptic revision THAs had a 2% incidence of subsequent revision of the FTC for aseptic loosening at 15 years. Dislocation and infection were the most common reasons for any revision.

Level of Evidence:
Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Comparison of the oral health status of nursing home residents using the current and the newly developed interRAI Oral Health Section (OHS-interRAI): a cross-sectional study
Authors: Schoebrechts Emilie , Mello Johanna de Almeida , Vandenbulcke Patricia A. I. , Hout Hein P. J. van , De Lepeleire Jan , Declercq Anja , Declerck Dominique , Duyck Joke 
Published: June 2024

Abstract

Background:
Nursing home residents’ oral health is generally poor, which can negatively affect general health and well-being. Regular dental check-ups and good oral hygiene are important, but often challenging for older adults. The interRAI instrument for Long-Term Care Facilities (LTCF) enables caregivers to evaluate residents’ health, including oral health, and to integrate oral care into general care planning. Because the current oral health section in the interRAI instruments does not accurately identify oral care needs, the interRAI Oral Health Section (OHS-interRAI) was developed. The OHS-interRAI differs from the current section by including more items, response options and guidelines, photographs, instruction videos, and Collaborative Action Points to alert caregivers when oral care is needed.
This study describes and compares residents’ oral health status assessed by caregivers using the current section and the OHS-interRAI.
Methods:
This cross-sectional study includes data from baseline assessments of adults aged 65 years or older in Flemish and Dutch nursing homes, collected by caregivers. Assessments with the current section dated from October 2016 to January 2023, and with the OHS-interRAI from October 2020 to January 2023.
Results:
InterRAI assessments of 12476 residents from 158 nursing homes with the current section were compared with those of 1212 residents from 37 nursing homes with the OHS-interRAI.
Missing oral health data were less common with the current section than with the OHS-interRAI. A higher proportion of oral health problems was detected with the OHS-interRAI compared to the current section for chewing function (6.8% vs. 13.7%), dry mouth (7.6% vs. 9.8%), teeth (16.6% vs. 22.1%), and gums (3.1% vs. 7.8%). There was no significant difference in the proportion of residents with discomfort or pain in the mouth.
Conclusions:
Caregivers identified more oral health problems with the OHS-interRAI, which may be due to its additional features compared to the current section, such as photographs and extensive instructions. The Collaborative Action Points included in the OHS-interRAI support continuity of care and enable integration of oral care into general care. Further research is needed to evaluate whether the OHS-interRAI accurately identifies residents who need help with daily oral hygiene or referral to a dentist.
Unveiling the Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Diagnosis and Inflammatory Phenotyping: A Dissociation from Lung Function and Asthma Control
Authors: Fenhua Jin , Hui Lin , Lihua Yu , Wen Huang 
Published: June 2024

Abstract

Objective: This study aims to examine the association and clinical relevance of fractional exhaled nitric oxide (FENO) with lung function, sputum eosinophils, blood eosinophils, blood total IgE (TIgE), and asthma control test (ACT) score.
Methods: A total of 189 participants, consisting of 99 asthmatic out-patients and 90 healthy individuals, were recruited for the study conducted between May 2013 and December 2013. The study aimed to investigate the correlation between various factors, including the levels of FeNO, FEV1%pred, ACT scores, sputum eosinophils, blood eosinophils, and TIgE, in asthma patients.
Results: The results revealed that the levels of FeNO, blood eosinophils, and TIgE were significantly higher in asthma patients compared to healthy individuals (P<0.05). Additionally, the level of FEV1%pred was significantly lower in asthma patients compared to healthy individuals (P<0.05).There was no significant correlation between FeNO 1evel and FEV1%Pred（r=0.004，P>0.05），nor between FeNO level and ACT scores（r=-0.195，P>0.05）. Correlation analysis showed that，FENO level was positive correlated with sputum eosinophils（r=0.473, P<0.05）, blood eosinophils（r=0.315, P<0.05） and TIgE（r=0.305, P<0.05）.
Conclusion: The FENO can assist diagnosis of asthma because the level of FENO is increased in asthma patients. FENO is no significant correlation with FEV1%Pred and ACT score, but the FENO level is positive correlated with sputum eosinophils, blood eosinophils and TIgE. FENO could reflect airway inflammatory level, especially esoinophilic airway inflammation.
Genetic mapping of QTLs for resistance to bacterial leaf streak in hexaploid wheat
Authors: Acharya Krishna , Liu Zhaohui , Schachterle Jeffrey , Kumari Pooja , Manan Fazal , Xu Steven , Green Andrew , Faris Justin 
Published: June 2024

Abstract

Bacterial leaf streak (BLS), caused by Xanthomonas translucenspv. undulosa (Xtu) poses a significant threat to global wheat production. High levels of BLS resistance are rare in hexaploid wheat. Here, we screened 101 diverse wheat genotypes under greenhouse conditions to identify new sources of BLS resistance. Five lines showed good levels of resistance including the wheat variety Boost and the synthetic hexaploid wheat line W-7984. Recombinant inbred populations derived from the cross of Boost × ND830 (BoostND population) and W-7984 × Opata 85 (ITMI population) were subsequently evaluated in greenhouse and field experiments to investigate the genetic basis of resistance. QTLs on chromosomes 3B, 5A, and 5B were identified in the BoostND population. The 3B and 5A QTLs were significant in all environments, but the 3B QTL was the strongest under greenhouse conditions explaining 38% of the phenotypic variation, and the 5A QTL was the most significant in the field explaining up to 29% of the variation. In the ITMI population, a QTL on chromosome 7D explained as much as 46% of the phenotypic variation in the greenhouse and 18% in the field. BLS severity in both populations was negatively correlated with days to heading, and some QTLs for these traits overlapped, which explained the tendency of later maturing lines to have relatively higher levels of BLS resistance. The findings from this study will contribute to a better understanding of BLS resistance and aid in the development of molecular markers for efficient selection of resistance alleles in wheat breeding programs.