bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessments and developments in constructing a National Health Index for policy-making, in the UK
Authors: Freni-Sterrantino Anna , Prescott Thomas P , Ceely Greg , Glickman Myer , Holmes Chris 
Published: July 2024

Abstract
Composite indicators are useful for summarizing and comparing changes among different communities. The UK Office for National Statistics has created an annual England Health Index (2015–2018) comprised of three main health domains—lives, places, and people—to monitor health over time and across different geographical areas and evaluate the nation’s health. We reviewed the conceptual coherence and statistical requirements, focusing on three main steps: correlation analysis at different levels, comparison of the implemented weights, and a sensitivity and uncertainty analysis. Based on the results, we have highlighted features that have improved the statistical requirements of the forthcoming UK Health Index.
EU attacks on investor rights
Authors: Devereux Steven M 
Published: July 2024

Abstract
The European Commission, with the cooperation of the Court of Justice of the European Union (CJEU), continues a crusade against investors’ rights. This is done by reducing the rights of access by investors to an independent arbitral tribunal to resolve disputes and by making arbitral awards impossible to enforce. The CJEU judgments which are discussed in this article are arbitrary, lack logical argument, and ignore international law (in particular, the 1969 Vienna Convention on the Law of Treaties). Recent judgments by states that are not EU Member States have restored the validity of arbitral awards that were annulled by EU courts. The judgments show that they do not believe in the CJEU judgments, which have led to the cancellation of inter-EU Bilateral Investment Treaties and the annulment of Energy Charter Treaty awards.
Donor conception, direct-to-consumer genetic testing, choices, and procedural justice: an argument for reform of the Human Fertilisation and Embryology Act 1990
Authors: Redhead Caroline A B , Frith Lucy 
Published: July 2024

Abstract
In this article, using theories of procedural justice and ‘slow violence’, we consider potential reform of the Human Fertilisation and Embryology Act 1990. Our theoretical discussion is underpinned by findings from the ConnecteDNA project, exploring how people affected by donor conception experience direct-to-consumer genetic testing (DTCGT). The negative impacts of DTCGT, especially shock discoveries about the circumstances of someone’s conception in adulthood, are linked to donor anonymity, and how its continued protection is experienced as a barrier to the rights and agency of donor-conceived people. We focus on two key issues relating to the donor information access process set out in section 31ZA of the 1990 Act. The first is that it excludes certain cohorts of donor-conceived people, creating inequalities of access to donor information. The second is the impact of the use of DTCGT to search for that information. We discuss what a procedurally just process of law reform would look like, concluding that, whatever (prospective) approach to donor anonymity is taken, the donor information access process should be the same for all donor-conceived people. We thus argue that, even were the status quo to be maintained, reform of the donor information access process with retrospective effect would be required.
The Military Medicine Leadership Life Cycle: A Model for Longitudinal Leadership Development in Medicine—Undergraduate and Graduate Medical Education
Authors: Barry Erin S , Hartzell Joshua D , Durning Steven J , Yarnell Angela M 
Published: July 2024

ABSTRACT
Physicians must be leaders more than ever with innumerable challenges. Despite this need, there is a paucity of consistent leadership development (LD) from medical student to staff physician. Military medicine has additional challenges—working within a large health care organization, constant turnover, working in a variety of contexts—that make the need for LD even more pressing. The purpose of this paper is to describe the LD life cycle for military undergraduate and graduate medical education (UME and GME), providing examples for other organizations while identifying steps to meet the future needs in military medicine. The Health Professions Scholarship Program produces over 75% of graduates for military medicine each year. Yet, since learners are dispersed throughout civilian medical schools any LD results in a heterogeneous experience. Uniformed Services University has a 4-year LD program required for all students as well as other opportunities for leadership professional growth. Military GME programs are unique, requiring a military unique curriculum to prepare graduates for their initial assignments. Military unique curriculum vary, but include clinical topics relevant to military medicine as well as leadership. There is no Military Healthcare System-wide leadership curriculum used by everyone at this time. Based on these UME and GME approaches to LD, there have been multiple lessons learned formed on the authors experience and published literature: learners do not typically see themselves as leaders; learners want applicable curriculum with less lecturing and more application and discussion; programs are often siloed from one another and sharing curriculum content does not typically occur; no one-size-fits-all model. On the basis of the lessons learned and the current state of UME and GME leadership education, there are 5 recommendations to enhance UME and GME leadership programs: (1) develop a Health Professions Scholarship Program Leadership Curriculum; (2) develop a MHS GME Leadership Curriculum; (3) integrate UME and GME Leadership Curricula; (4) develop faculty to teach leadership; and (5) conduct research on UME and GME in military and share lessons learned. We suggest a roadmap for strengthening LD within military medicine and civilian institutions.
Delayed Diagnosis and Successful Glue Embolization of a Post-Traumatic Bronchial Artery Pseudoaneurysm: A Case Report
Authors: Yu Min-Hyuk , Kang Nam-Gyu , Jung Jae-Hyeop 
Published: July 2024

ABSTRACT
Bronchial artery pseudoaneurysms (BAPs) are rare but potentially fatal vascular anomalies. We present a case of a 21-year-old male soldier who developed a BAP following a fall sustained during a suicide attempt. The BAP was identified on computed tomography angiography (CTA) and successfully treated with trans-arterial glue embolization. The patient’s recovery was uncomplicated. To our knowledge, only one prior case of post-traumatic BAP treated with endovascular intervention has been reported in the literature (29 years ago). Due to the risk of significant morbidity and mortality associated with BAP rupture, prompt diagnosis and treatment are crucial. Endovascular embolization is a safe and effective treatment option for BAPs. This case highlights the effectiveness of glue embolization as a treatment modality for BAPs.
The Gaia-ESO Survey: 3D dynamics of young groups and clusters from GES and Gaia EDR3
Authors: Wright Nicholas J , Jeffries R D , Jackson R J , Sacco G G , Arnold Becky , Franciosini E , Gilmore G , Gonneau A , Morbidelli L , Prisinzano L , Randich S , Worley Clare C 
Published: July 2024

ABSTRACT
We present the first large-scale 3D kinematic study of $\sim$2700 spectroscopically confirmed young stars ($\lt $20 Myr) in 18 star clusters and OB associations (hereafter groups) from the combination of Gaia astrometry and Gaia–ESO Survey spectroscopy. We measure 3D velocity dispersions for all groups, which range from 0.61 to 7.4 km s$^{-1}$ (1D velocity dispersions of 0.35–4.3 km s$^{-1}$). We find the majority of groups have anisotropic velocity dispersions, suggesting they are not dynamically relaxed. From the 3D velocity dispersions, measured radii, and estimates of total mass, we estimate the virial state and find that all systems are super-virial when only the stellar mass is considered, but that some systems are sub-virial when the mass of the molecular cloud is taken into account. We observe an approximately linear correlation between the 3D velocity dispersion and the group mass, which would imply that the virial state of groups scales as the square root of the group mass. However, we do not observe a strong correlation between virial state and group mass. In agreement with their virial state, we find that nearly all of the groups studied are in the process of expanding and that the expansion is anisotropic, implying that groups were not spherical prior to expansion. One group, Rho Oph, is found to be contracting and in a sub-virial state (when the mass of the surrounding molecular cloud is considered). This work provides a glimpse of the potential of the combination of Gaia and data from the next generation of spectroscopic surveys.
Probing cosmic background dynamics with a cosmological-model-independent method
Authors: Liu Yang , Wang Bao , Yu Hongwei , Wu Puxun 
Published: July 2024

ABSTRACT
The Hubble constant $H_0$ tension has emerged as the most serious crisis in modern cosmology, potentially indicating that the $\Lambda$CDM model may not describe our Universe accurately. In this paper, we establish a new, cosmological-model-independent method to study the cosmic background dynamics. Using the latest Pantheon+ Type Ia supernova (SN Ia) sample and the model-independent SN Ia sample (P+1690), we derive values for the luminosity distance, the Hubble parameter, and the deceleration parameter at five different redshift points ranging from 0.12 to 0.52. Our analysis shows that results obtained from the Pantheon+ sample align with the predictions of the $\Lambda$CDM model within 2$\sigma$ confidence level (CL), while those obtained from the P+1690 sample exhibit deviations of about $2\sim 3\sigma$ CL. Furthermore, we explore the equation of state (EoS) of dark energy and find that while the EoS values from the Pantheon+ sample remain consistent with $-1$ within 2$\sigma$ CL, the P+1690 sample does not conform to this standard. These findings remain unchanged after the inclusion of the Hubble parameter measurements in our analysis. Our results indicate that the $\Lambda$CDM model remains compatible with the Pantheon+ SN Ia and the Hubble parameter measurements at 2$\sigma$ CL.
Influence of selection criteria on the interpretation of rotational behaviour of wide-binary star systems
Authors: Cookson S A 
Published: July 2024

ABSTRACT
Binary star systems are expected to follow Newtonian dynamics similarly to planetary systems. However, reports have been made of wide binary systems with separations around 0.01 pc and larger, showing potential deviations from standard Newtonian motion. This phenomenon, suggestive of the flattening of galactic rotation curves, calls for closer inspection. This study presents an analysis of wide binary stars using data from Gaia Data Release 3 (DR3), a space-based astrometry mission funded by the European Space Agency. The study compares different choices of selection criteria to examine the nature of these apparent anomalous kinematics within the solar neighbourhood. The Gaia data set furnishes detailed parameters, including radial velocity, mass, age, and binary probability in addition to standard parameters. A custom Python tool named bynary facilitated both data processing and analysis. This report reveals that the signs of any anomalous signals systematically diminish as the initial selection criteria are relaxed for degrouping while subsequent filtering remains stringent, leading to the complete elimination of any apparent non-Newtonian motion for binary separations within 0.5 pc. The study shows that any observed anomalous behaviour in solar neighbourhood wide binaries within 130 pc must be produced either by faint companion stars orbiting primary or secondary stars, or by flyby stars. The findings emphasize the importance of the choice of selection criteria in disentangling genuine binary dynamics from external influences. The conclusions align with the predictions of Newtonian mechanics and general relativity, though they do not exclude other phenomena at larger scales.
A systematic IR and VUV spectroscopic investigation of ion, electron, and thermally processed ethanolamine ice
Authors: Zhang Jin , Muiña Alejandra Traspas , Mifsud Duncan V , Kaňuchová Zuzana , Cielinska Klaudia , Herczku Péter , Rahul K K , Kovács Sándor T S , Rácz Richárd , Santos Julia C , Hopkinson Alfred T , Craciunescu Luca , Jones Nykola C , Hoffmann Søren V , Biri Sándor , Vajda István , Rajta István , Dawes Anita , Sivaraman Bhalamurugan , Juhász Zoltán , Sulik Béla , Linnartz Harold , Hornekær Liv , Fantuzzi Felipe , Mason Nigel J , Ioppolo Sergio 
Published: July 2024

ABSTRACT
The recent detection of ethanolamine (EtA, HOCH$_2$CH$_2$NH$_2$), a key component of phospholipids, i.e. the building blocks of cell membranes, in the interstellar medium is in line with an exogenous origin of life-relevant molecules. However, the stability and survivability of EtA molecules under inter/circumstellar and Solar System conditions have yet to be demonstrated. Starting from the assumption that EtA mainly forms on interstellar ice grains, we have systematically exposed EtA, pure and mixed with amorphous water (H$_2$O) ice, to electron, ion, and thermal processing, representing ‘energetic’ mechanisms that are known to induce physicochemical changes within the ice material under controlled laboratory conditions. Using infrared (IR) spectroscopy, we have found that heating of pure EtA ice causes a phase change from amorphous to crystalline at 180 K, and further temperature increase of the ice results in sublimation-induced losses until full desorption occurs at about 225 K. IR and vacuum ultraviolet (VUV) spectra of EtA-containing ices deposited and irradiated at 20 K with 1 keV electrons as well as IR spectra of H$_2$O:EtA mixed ice obtained after 1 MeV He$^+$ ion irradiation have been collected at different doses. The main radiolysis products, including H$_2$O, CO, CO$_2$, NH$_3$, and CH$_3$OH, have been identified and their formation pathways are discussed. The measured column density of EtA is demonstrated to undergo exponential decay upon electron and ion bombardment. The half-life doses for electron and He$^+$ ion irradiation of pure EtA and H$_2$O:EtA mixed ice are derived to range between $10.8\!-\!26.3$ eV/16u. Extrapolating these results to space conditions, we conclude that EtA mixed in H$_2$O ice is more stable than in pure form and it should survive throughout the star and planet formation process.
Ru3@Mo2CO2 MXene single-cluster catalyst for highly efficient N2-to-NH3 conversion
Authors: Zhang Cong , Wang Ze-Hui , Wang Haiyan , Liang Jin-Xia , Zhu Chun , Li Jun 
Published: July 2024

ABSTRACT
Single-cluster catalysts (SCCs) representing structurally well-defined metal clusters anchored on support tend to exhibit tunable catalytic performance for complex redox reactions in heterogeneous catalysis. Here we report a theoretical study on an SCC of Ru3@Mo2CO2 MXene for N2-to-NH3 thermal conversion. Our results show that Ru3@Mo2CO2 can effectively activate N2 and promotes its conversion to NH3 through an association mechanism, in which the rate-determining step of NH2* + H* → NH3* has a low energy barrier of 1.29 eV. Notably, with the assistance of Mo2CO2 support, the positively charged Ru3 cluster active site can effectively adsorb and activate N2, leading to 0.74 |e| charge transfer from Ru3@Mo2CO2 to the adsorbed N2. The supported Ru3 also acts as an electron reservoir to regulate the charge transfer for various intermediate steps of ammonia synthesis. Microkinetic analysis shows that the turnover frequency of the N2-to-NH3 conversion on Ru3@Mo2CO2 is as high as 1.45 × 10−2 s−1 site−1 at a selected thermodynamic condition of 48 bar and 700 K, the performance of which even surpasses that of the Ru B5 site and Fe3/θ-Al2O3(010) reported before. Our work provides a theoretical understanding of the high stability and catalytic mechanism of Ru3@Mo2CO2 and guidance for further designing and fabricating MXene-based metal SCCs for ammonia synthesis under mild conditions.
Construction of chiral crown ethers in robust covalent organic frameworks for electrochromatographic enantioseparation
Authors: Fu Shiguo , Qin Gaizhao , Dong Jinqiao , Yuan Chen , Liu Yan , Yuan Li-Ming , Cui Yong 
Published: July 2024

ABSTRACT
Capillary electrochromatography (CEC) is a rapidly emerging separation technique that merges the high separation efficiency of capillary electrophoresis with the exceptional selectivity of liquid chromatography. However, it remains a synthetic challenge to design functional chiral stationary phases (CSPs) with high chemical stability against acid and base in CEC enantioseparation. Here we demonstrate that incorporating chiral crown ethers into stable covalent organic frameworks (COFs) enables efficient and stable separations of racemates by CEC. This facilitates the crafting of two three-dimensional (3D) chiral COFs by polycondensation of a chiral 1,1'-binaphyl-20-crown-6-derived dialdehyde and tetraamines with diisopropyl substituents. Both feature an 11-fold interpenetrated diamond framework, characterized by tubular open channels decorated with chiral crown ethers serving as enantioselective recognition and binding sites. These frameworks demonstrate excellent stability in water, acid and base, thanks to the presence of bulky isopropyl groups that shield the dynamic imine linkages. Moreover, the precisely defined COF channels enhanced the accessibility of the enclosed crown ethers to the analytes while providing strong protection against harsh environments, rendering them suitable for CSPs in CEC separations. They can effectively separate some important enantiomers, including ketones, epoxides and alkaline substances, when utilized as coatings on chiral columns, particularly facilitating the chiral separation of drugs. This study advances the application of COFs in electrochromatographic separations, expanding the scope of porous materials design and engineering to create COFs with targeted enantioselective properties.
Liver involvement with Langerhans cell histiocytosis in adults
Authors: Chang Long , Cai Hua-Cong , Lang Min , Lin He , Luo Ya-Ping , Duan Ming-hui , Zhou Dao-bin , Goyal Gaurav , Cao Xin-xin 
Published: July 2024

Abstract

Background and Aims
Liver involvement portends poor prognosis in adults. We aimed to characterize the clinical features, liver function tests, radiologic findings, molecular profiles, therapeutic approaches and outcomes of adults patients with Langerhans cell histiocytosis (LCH) with liver involvement.

Methods
We conducted a retrospective analysis of all adults with LCH (≥ 18 years) seen at Peking Union Medical College Hospital (Beijing, China) between January 2001 and December 2022.

Results
Among the 445 newly diagnosed adults with LCH, 90 patients had liver involvement at diagnosis and 22 patients at relapse. The median age was 32 years (range, 18–66 years). Of 112 evaluable patients, 108 had full liver function testing, including alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase (ALP), γ-glutamyl transpeptidase (GGT), and total bilirubin and albumin. Elevated ALP was seen in 63.0% and GGT in 86.1%; 14.8% had elevated bilirubin. Next-generation sequencing of 54 patients revealed frequent BRAFN486_P490 (29.6%), BRAFV600E (18.5%), and MAP2K1 (14.8%).

Outcomes
After a median 40 months’ follow-up (range 1-168 months), 3-year progression-free survival (PFS) and overall survival were 49.7% and 86.6% respectively. In multivariable analyses, ≥3 abnormal liver function tests (HR 3.384, 95% CI 1.550–7.388, P = .002) associated with inferior PFS; immunomodulatory drug therapy (HR 0.073, 95% CI, 0.010-0.541, P = .010) correlated with superior PFS versus chemotherapy.

Conclusions
In summary, elevated GGT and ALP were common in adults with LCH liver involvement. Greater than equal to 3 abnormal liver function tests predicted poor outcomes. Immunomodulatory drug therapy was associated with favorable progression-free survival compared to chemotherapy.
Immune-related adverse events requiring hospitalization in patients with lung cancer: implications and insights
Authors: Falade Ayo , Zubiri Leyre , Wu Chia-Yun , Perlman Katherine , Sun Joie , Hathaway Nora , Grealish Kelley , Lopiccolo Jackie , Reynolds Kerry , Mooradian Meghan J 
Published: July 2024

Abstract

Background
Immune checkpoint inhibitors (ICI) are associated with a distinct spectrum of toxicities. Data on irAE hospitalization rates and clinical course of patients with thoracic malignancies are lacking.

Methods
Patients with advanced thoracic malignancy treated with ICI (2/2016 to 6/2021) were retrospectively identified. Demographic and clinical data of confirmed irAE hospitalizations were extracted from the medical record and a descriptive analysis was performed.

Results
From February 2016 to June 2021, 1312 patients with thoracic malignancy received ICI (monotherapy, combination with 2nd ICI or other agents) with 102 patients (7.7%) hospitalized for irAEs. Treatment intent was first-line therapy in most patients (N = 50, 49%) with 9% (n = 9) receiving adjuvant ICI (N = 9). Sixty patients (59%) received ICI alone, 32% (N = 33) chemo plus immunotherapy, and 7% (N = 7) dual ICI. The median age on admission was 68 years. The median time between ICI initiation and admission was 64 days (1-935 days). Pneumonitis (32.3%; 33/102) was the most frequent indication for admission followed by gastroenterocolitis (19.6%; 20/102), hepatitis (12.7%; 13/102), myo/pericarditis (9.8%; 10/102), and endocrinopathies (9.8%; 10/102). Multi-organ toxicity occurred in 36% (N = 37) of patients. Overall, 85.2% (87/102) of patients received systemic corticosteroids and 17.6% (18/102) required additional lines of immunosuppression. The median length of hospitalization stay was 7 days (2-28 days) with a 25.5% (n = 26) readmission rate within 60 days and an 11.8% (n = 12) in house mortality rate.

Conclusions
Severe irAE requiring inpatient admission, although infrequent, results in considerable morbidity, mortality, and healthcare utilization. Pneumonitis was the most common irAE requiring inpatient management in our patient population with a significant risk of mortality despite the use of guideline-directed systemic immunosuppression. This study highlights the continued need for collaborative efforts amongst medical specialties for improving the diagnostic and therapeutic management of patients with irAEs.