bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic Effects of Intracoronary Nitroglycerin during Coronary Angiography in Children after Heart Transplantation
Authors: Lara Diego A. , Olive Mary K. , George James F. , Brown Robert N. , Carlo Waldemar F. , Colvin Edward V. , Steenwyck Brad L. , Pearce F. Bennett 
Published: February 2014

Coronary spasm during coronary angiography for vasculopathy in children can be prevented by the intracoronary administration of nitroglycerin. We reviewed the anesthesia and catheterization reports and charts for pediatric transplant recipients who underwent angiography from 2005 through 2010. Correlation analysis was used to study the relation of post-injection systolic blood pressure (SBP) to nitroglycerin dose. Forty-one angiographic evaluations were performed on 25 patients (13 male and 12 female). Mean age was 9.9 ± 3.2 years (range, 3.3–16.1 yr). The mean total dose of nitroglycerin was 2.93 ± 1.60 µg/kg (range, 1–8 µg/kg).
There was a significant drop between the baseline SBP (mean, 106 ± 21.6 mmHg) and the lowest mean SBP before nitroglycerin administration (78 ± 13.2, P <0.0001, paired t test). There was no significant additional change in SBP (mean after nitroglycerin administration, 80.7 ± 13.1 mmHg; P = 0.2). There was a significant drop in lowest heart rate between baseline (109 ± 16.5 beats/min) and before nitroglycerin administration (89 ± 14.3 beats/min; P <0.0001, paired t test). There was no significant additional change in heart rate (mean heart rate after nitroglycerin, 84 ± 17.7 beats/min; P = 0.09). There were 2 interventions for SBP before nitroglycerin and 2 after nitroglycerin. One child experienced a transient ST-T–segment change during angiography after nitroglycerin. In the highest dose range, the additional decrease in SBP was 7.2 mmHg (P=0.03). Routine intracoronary nitroglycerin administration in this dose range produced no significant changes in SBP or heart rate in children.
Percutaneous Coronary Intervention to Treat Chronic Total Occlusion: Predictors of Technical Success and One-Year Clinical Outcome
Authors: Salarifar Mojtaba , Mousavi Mohammad-Reza , Saroukhani Sepideh , Nematipour Ebrahim , Kassaian Seyed Ebrahim , Alidoosti Mohammad , Poorhosseini Hamid-Reza , Haji-Zeinali Ali-Mohammad , Nozari Younes , Hosseini Kianoush , Jalali Arash 
Published: February 2014

We investigated the overall success rate of percutaneous coronary intervention (PCI) as a treatment for coronary chronic total occlusion and sought to determine the predictive factors of technical success and of one-year major adverse cardiac events (MACE). These factors have not been conclusively defined.
Using data from our single-center PCI registry, we enrolled 269 consecutive patients (mean age, 56.13 ± 10.72 yr; 66.2% men) who underwent first-time PCI for chronic total occlusion (duration, ≥3 mo) from March 2006 through September 2010. We divided them into 2 groups: procedural success and procedural failure. We compared occurrences of in-hospital sequelae and one-year MACE between the groups, using multivariate models to determine predictors of technical failure and one-year clinical outcome.
Successful revascularization was achieved in 221 patients (82.2%). One-year MACE occurred in 13 patients (4.8%), with a predominance of target-vessel revascularization (3.7%). The prevalence of MACE was significantly lower in the procedural-success group (1.8% vs 18.8%; P <0.001). In the multivariate model, technical failure was the only predictor of one-year MACE. The predictors of failed procedures were lesion location, multivessel disease, the occurrence of dissection, a Thrombolysis In Myocardial Infarction flow grade of 0 before PCI, the absence of tapered-stump arterial structure, and an increase in serum creatinine level or lesion length.
In our retrospective, observational study, PCI was successful in a high percentage of chronic total occlusion patients and had a low prevalence of complications. This suggests its safety and effectiveness as a therapeutic option.
Acute Myocardial Infarction Associated with Dietary Supplements Containing 1,3-Dimethylamylamine and Citrus aurantium
Authors: Smith Triston B. , Staub Brian A. , Natarajan Gayathri M. , Lasorda David M. , Poornima Indu G. 
Published: February 2014

We describe the case of a previously healthy 22-year-old man who presented with anginal chest pain and was diagnosed with a non-ST-elevation myocardial infarction. For 3 weeks, he had been ingesting the dietary supplements Jack3d® (principal ingredient, 1,3-dimethylamylamine) and Phenorex™ (principal ingredient, Citrus aurantium) daily, before undertaking physical activity. Coronary angiograms revealed a proximal left anterior descending coronary artery thrombus with distal embolization. A combined medical regimen led to resolution of the thrombus. Three months later, the patient was asymptomatic with no evidence of ischemia.
The primary ingredients in the sympathomimetic supplements taken by our patient are controversial in the medical community and have been individually associated with adverse cardiac events. There are no safety data on their simultaneous use. We discuss other reports of adverse effects associated with these supplements and recommend that the relevant safety guidelines be revised.
A Patient with Giant Left Atrium Undergoes Orthotopic Heart Transplantation
Authors: Boldyrev Sergey Y. , Lepshokov Murat K. , Yakuba Igor I. , Barbukhatty Kirill O. , Porhanov Vladimir A. 
Published: February 2014

We present a novel technique for resolving the problem of radical size mismatch at the time of orthotopic transplantation. A 48-year-old man presented with chronic rheumatic heart disease and a giant left atrium. Twenty-three years before, he had undergone mitral valve replacement with a mechanical prosthesis. At the time of the repeated intervention, the volume of his left atrium was 350 mL.
Surgical features of the transplantation included approximation of the pulmonary vein ostia by gathering sutures intentionally, in order to decrease the area of the left atrial posterior wall and thereby enable appropriate coaptation with the donor left atrium. After the operation, left atrial volume had been reduced to 60 mL.
Papillary Muscle Repositioning as a Subvalvular Apparatus Preservation Technique in Mitral Stenosis Patients with Normal Left Ventricular Systolic Function
Authors: Lafci Gokhan , Cagli Kerim , Cicek Omer Faruk , Korkmaz Kemal , Turak Osman , Uzun Alper , Yalcinkaya Adnan , Diken Adem , Gunertem Eren , Cagli Kumral 
Published: February 2014

Subvalvular apparatus preservation is an important concept in mitral valve replacement (MVR) surgery that is performed to remedy mitral regurgitation. In this study, we sought to determine the effects of papillary muscle repositioning (PMR) on clinical outcomes and echocardiographic left ventricular function in rheumatic mitral stenosis patients who had normal left ventricular systolic function.
We prospectively assigned 115 patients who were scheduled for MVR surgery with mechanical prosthesis to either PMR or MVR-only groups. Functional class and echocardiographic variables were evaluated at baseline and at early and late postoperative follow-up examinations. All values were compared between the 2 groups.
The PMR group consisted of 48 patients and the MVR-only group of 67 patients. The 2 groups’ baseline characteristics and surgery-related factors (including perioperative mortality) were similar. During the 18-month follow-up, all echocardiographic variables showed a consistent improvement in the PMR group; the mean left ventricular ejection fraction deteriorated significantly in the MVR-only group. Comparison during follow-up of the magnitude of longitudinal changes revealed that decreases in left ventricular end-diastolic and end-systolic diameters and in left ventricular sphericity indices, and increases in left ventricular ejection fractions, were significantly higher in the PMR group than in the MVR-only group.
This study suggests that, in patients with rheumatic mitral stenosis and preserved left ventricular systolic function, the addition of papillary muscle repositioning to valve replacement with a mechanical prosthesis improves left ventricular dimensions, ejection fraction, and sphericity index at the 18-month follow-up with no substantial undesirable effect on the surgery-related factors.
Cerebral stroke injury: the role of cytokines and brain inflammation
Authors: Siniscalchi Antonio , Gallelli Luca , Malferrari Giovanni , Pirritano Domenico , Serra Raffaele , Santangelo Ermenegildo , De Sarro Giovambattista 
Published: February 2014

Abstract
Stroke represents the most frequent cause of permanent disability in adults worldwide. Cerebral ischemia triggers the pathological pathways of the ischemic cascade and causes irreversible neuronal injury in the ischemic core within minutes of the onset. Elements of the immune system are involved in all stages of ischemic cascade from acute intravascular events triggered by the interruption of blood supply, to the parenchymal processes leading to brain damage and to the ensuing tissue repair. In this review, we will provide a brief overview of current understanding of the role of cytokines and brain inflammation during acute ischemic stroke.
Analysis of measurement process of placental volume in early pregnancy: an interobserver reliability study
Authors: Florido Jesús , Ocón Olga , de Dios Luna del Castillo Juan , Vega-Cañadas Javier , Manrique-Espinoza Nadya , Navarrete Luis 
Published: February 2014

Abstract

Objective: To examine concordance among results obtained in measurement process of first-trimester placental volume using 3D ultrasound and eXtended Imaging Virtual Organ Computed-aided AnaLysis (XI-VOCAL®, 3DXITM, Medison, Seoul, Korea) image analysis by three different operators.

Methods: Twenty first-trimester normal pregnancy cases were selected for placental volume measuring using a Medison SA 8000 Live Prime® (Medison, Seoul, Korea) with a convex volumetric multifrequency abdominal probe. Images were processed and studied independently by three operators with different grade of training. Each operator obtained 50 slices per case. Thus, this study is based on 1000 measurements that have generated four different sets of placental volume determinations based on 5, 10, 15, and 20 slices, respectively. Results of measurement process were analyzed using reliability coefficients.

Results: There was a good degree of concordance in the placental length values obtained by all operators and not depend from the number of cuts measured [intraclass correlation coefficient (ICC)=0.734]. However, the number of cuts is important to obtain a placental volume with more accuracy. Reliability coefficients were low when determining placental volume adjusted to placental length (ICC=0.293), but combined results of the two operators that were trained in the same way showed higher coefficients of reliability (ICC=0.682), and therefore, greater concordance when comparing with the operator that was not trained in the same way.

Conclusion: Higher coefficients of reliability guarantee high grades of concordance in the results among operators when measuring placental volumes independently, however, contouring process introduces high variability. Training in how to best use the image analysis software effectively assists in getting higher coefficients of reliability.
Targeted hyperthermia-induced cancer cell death by superparamagnetic iron oxide nanoparticles conjugated to luteinizing hormone-releasing hormone
Authors: Mohammad Faruq , Raghavamenon Achuthan C. , Claville Michelle O. , Kumar Challa S.S.R. , Uppu Rao M. 
Published: February 2014

Abstract
The hyperthermia-induced cytotoxicity of gold-coated SPIONs conjugated to LHRH (SPIONs@Au-LHRH) has been studied in LHRH-receptor overexpressing murine GT1-7 hypothalamic neurons (noncancerous) and human LNCaP cells (cancerous). In the absence of an external magnetic field, SPIONs@Au-LHRH were least cytotoxic to either cell type. When cells were pretreated with SPIONs@Au-LHRH and then exposed to a magnetic field (465 Oe for 15 or 2×15 min), both cell types showed marked decreases in viability and proliferation. The cell death in GT1-7 neurons was found to be late apoptosis or early necrosis, while necrosis was prominent in LNCaP cells. The LNCaP cells exposed to the magnetic field for 15 min showed a significant drop in the mitochondrial transmembrane potential; however, no such change was evident in GT1-7 neurons for the first 15 min. The cell death in LNCaP cells was found to be mediated through the caspase-3-dependent pathway. There was an increased expression of heat shock protein 70 in GT1-7 neurons, and no such increase was seen in LNCaP cells. It is suggested that noncancerous GT1-7 neurons are more resistant to the heat-induced cytotoxicity of SPIONs@Au-LHRH than are LNCaP cells due to increased expression of HSP70. The results show promise toward the selective tumoricidal actions of targeted magnetic nanoparticles.
Effect of reaction conditions on the thermal stability of polystyrene grafted oil palm empty fruit bunch (OPEFB) fiber
Authors: Jamarosliza Jamaluddin , Hasan Mahbub , Hassan Azman , Ibrahim Nor Azowa , Ahmad Mansor , Rahman Zaki Ab. , Yunus Wan Md Zin Wan 
Published: February 2014

Abstract
Polystyrene was grafted onto oil palm empty fruit bunch (OPEFB) fiber in aqueous medium by using the H2O2/Fe2+ system as an initiator. Optimization of the reaction conditions was carried out by varying the reaction period, temperature, amounts of the monomer, initiator and co-catalyst. The presence of the peaks around 3026 cm-1, 698 cm-1 and 755 cm-1 in the Fourier transform infrared (FTIR) spectra of the grafted product and the presence of polystyrene on the surface of grafted OPEFB in the scanning electron micrograph provided strong evidence of the grafting. The maximum percentage of grafting (about 200%) was achieved when the reaction was carried on for 4 h at a temperature of 65°C, using 52.27 mmol monomer, 6.00 mmol initiator and 0.26 mmol co-catalyst. The thermal stability of the grafted OPEFB was found to be better than that of the ungrafted fiber, as seen from thermogravimetric analysis (TGA).
Recent advances in study of uranium surface chemistry in China
Authors: Luo Lizhu , Lai Xinchun , Wang Xiaolin 
Published: February 2014

Abstract
Uranium is very important in nuclear energy industry; however, uranium and its alloys corrode seriously in various
atmospheres because of their chemical reactivities. In China, continuous investigations focused on surface chemistry have been carried
out for a thorough understanding of uranium in order to provide technical support for its engineering applications. Oxidation kinetics
of uranium and its alloys in oxidizing atmospheres are in good agreement with those in the literature. In addition to the traditional
techniques, non-traditional methods have been applied for oxidation kinetics of uranium, and it has been verified that spectroscopic
ellipsometry and X-ray diffraction are effective and nondestructive tools for in situ kinetic studies. The inhibition
efficiency of oxidizing gas impurities on uranium hydrogenation is found to follow the order CO2 > CO > O2, and the
broadening of XPS shoulders with temperature in depth profile of hydrogenated uranium surface is discussed, which is not mentioned in
the literature. Significant progress on surface chemistry of alloyed uranium (U-Nb and U-Ti) in hydrogen atmosphere is reported, and it
is revealed that the hydrating nucleation and subsequent growth of alloyed uranium are closely connected with the surface states,
underlying metal matrix, and it is microstructure-dependent. In this review, the recent advances in uranium surface chemistry in China,
published so far mostly in Chinese language, are briefly summarized. Suggestions for further study are made.
The Use of Light/Chemically Hardened Polymethylmethacrylate, Polyhydroxylethylmethacrylate, and Calcium Hydroxide Graft Material in Combination With Polyanhydride Around Implants and Extraction Sockets in Minipigs: Part II: Histologic and Micro‐CT Evaluations
Authors: Hasturk Hatice , Kantarci Alpdogan , Ghattas Mazen , Dangaria Smit J. , Abdallah Rima , Morgan Elise F. , Diekwisch Thomas G.H. , Ashman Arthur , Van Dyke Thomas 
Published: February 2014

Background: This report is the second part of the previously published study on the impact of light/chemical hardening technology and a newly formulated composite graft material for crestal augmentation during immediate implant placement.Methods: A total of 48 implants were placed into the sockets of the mesial roots of freshly extracted mandibular premolar teeth in three minipigs. Crestal areas and intrabony spaces were randomly augmented with light‐hardened graft materials including a composite graft consisting of polymethylmethacrylate, polyhydroxylethylmethacrylate, and calcium hydroxide (PPCH) plus polyanhydride (PA); PPCH graft; and PA graft, or left untreated. Distal sockets not receiving implants and the sockets of first molars (n = 60) were randomly treated with one of the graft materials or left empty. In addition, two molar sockets were treated with the original PPCH graft material. Quantitative microcomputed tomography (micro‐CT) was used to assess alveolar bone structure and tissue compositions. Histologic evaluations included descriptive histology to assess the peri‐implant wound healing, as well as histomorphometric measurements to determine bone‐to‐implant contact (BIC).Results: Both trabecular and cortical bone measurements by micro‐CT did not reveal any significant differences among the groups. Sites augmented with PPCH+PA resulted in significantly greater BIC surface than PPCH alone and no‐graft‐treated implants (P <0.05) histologically. Stained ground sections showed complete bone formation between bone and implant surface in the PPCH+PA group, whereas sites without augmentation showed large gaps between bone and implant surfaces, indicating a slower bone apposition and less BIC surface compared to all other groups. Similar to implant sections, all materials showed positive outcome on trabecular and cortical bone formation in extraction sockets with an intact crestal cortical bone.Conclusion: Histologic evaluations supported the previous findings on implant stability and function and confirmed that PPCH+PA provides a greater BIC with a well‐organized implant–bone interface and is useful in crestal augmentation during immediate implant placement.
Quantification of Periodontal Pathogens in Vascular, Blood, and Subgingival Samples From Patients With Peripheral Arterial Disease or Abdominal Aortic Aneurysms
Authors: Figuero Elena , Lindahl Christeel , Marín María José , Renvert Stefan , Herrera David , Ohlsson Ola , Wetterling Thomas , Sanz Mariano 
Published: February 2014

Background: The aim of this investigation is to quantify periodontal pathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Campylobacter rectus, and Tannerella forsythia) in vascular, blood, and subgingival samples. As a secondary objective, two molecular bacterial identification methods (nested polymerase chain reaction [PCR] and quantitative PCR [qPCR]) are compared.Methods: Seventy consecutive patients provided a vascular lesion, a blood sample, and 36 subgingival samples. Bacterial DNA was extracted, and qPCR was used to determine the prevalence and amounts of the target pathogens in each sample. Nested PCR was performed only in the samples from vascular lesions. Periodontal examination was performed in 42 patients. Mann‐Whitney U or χ2 tests were used to compare microbiologic results according to periodontal diagnosis.Results: All targeted periodontal pathogens (A. actinomycetemcomitans, P. gingivalis, T. forsythia, or C. rectus) were detected in subgingival samples, with a prevalence rate of 72.2%, 47.2%, 74.3%, and 82.9%, respectively. In 7.1% and 11.4% of vascular and blood samples, bacterial DNA was detected. One patient was positive for A. actinomycetemcomitans in the three types of samples. No differences were found in the levels of targeted bacteria when comparing patients with and without periodontitis. Prevalence rates obtained with nested PCR were significantly higher than those obtained with qPCR.Conclusions: The presence of A. actinomycetemcomitans was demonstrated in vascular, blood, and subgingival samples in one of 36 patients. These results, although with a very low frequency, may support the hypothesis of a translocation of periodontal pathogens from subgingival microbiota to the bloodstream and then to atheromatous plaques in carotid or other peripheral arteries. Nested PCR is not an adequate method for identifying DNA of periodontal pathogens in low quantities because of the high number of false‐negative results.
Immediate Placement of Dental Implants in the Esthetic Zone: A Systematic Review and Pooled Analysis
Authors: Slagter Kirsten W. , den Hartog Laurens , Bakker Nicolaas A. , Vissink Arjan , Meijer Henny J.A. , Raghoebar Gerry M. 
Published: February 2014

Background: Research interest on immediate placement of dental implants has shifted from implant survival toward optimal preservation of soft and hard tissues. The aim of this study is to systematically assess the condition of implant survival, peri‐implant hard and soft tissue changes, esthetic outcome, and patient satisfaction of immediately placed single‐tooth implants in the esthetic zone.Methods: MEDLINE, EMBASE, and CENTRAL databases were searched for publications up to June 2013. Studies reporting on implant survival, changes in hard and soft peri‐implant tissues, esthetic outcome, and patient satisfaction were considered. A pooled analysis was performed to identify factors associated with survival and peri‐implant tissue changes after immediate implant placement.Results: Thirty‐four studies were considered eligible. Immediate placement of single‐tooth implants in the esthetic zone was accompanied by excellent 1‐year implant survival (97.1%, 95% confidence interval [CI]: 0.958 to 0.980). Mean marginal peri‐implant bone loss was 0.81 ± 0.48 mm, mean loss of interproximal peri‐implant mucosa level was 0.38 ± 0.23 mm, and mean loss of peri‐implant midfacial mucosa level was 0.54 ± 0.39 mm. Regression analysis revealed that delayed provisionalization (odds ratio [OR] 58.03, 95% CI: 8.05 to 418.41, P <0.000), use of a flap (OR 19.87, 95% CI: 10.21 to 38.66, P <0.000), and use of a connective tissue graft (OR 4.56, 95% CI: 1.72 to 12.08, P <0.002) were associated with marginal peri‐implant bone‐level change >0.50 mm. Because of underreporting, esthetic results and patient outcome did not allow for reliable analysis.Conclusion: Immediate placement with immediate provisionalization of dental implants in the esthetic zone results in excellent short‐term treatment outcome in terms of implant survival and minimal change of peri‐implant soft and hard tissue dimensions.
Voluntary Income Reporting
Authors: Beaulieu Philip 
Published: February 2014

SYNOPSIS
This paper proposes a voluntary income-reporting regime, in which firms could choose whether to publish an income statement. Firms choosing not to issue it would report fund flows in a cash flow statement employing the direct method, similar to the cash flow statement advocated by Ohlson et al. (2010). Voluntary income reporting is motivated by managers' numerous motives to manipulate earnings, recent research challenging the value relevance of earnings compared to cash flows, and costs of auditing income, including litigation risk. Another motivation for voluntary income reporting is rising investor dissatisfaction with reported earnings, but unlike many critics in the investing community, the paper does not claim that earnings do not have significant information value. Rather, given recent developments, it is worth reconsidering whether the benefits of reporting accrual earnings exceed the costs for all firms.