bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence and clinical impact of concurrent chronic total occlusion according to gender in ST‐Elevation myocardial infarction
Authors: Bataille Yoann , Déry Jean‐Pierre , Larose Éric , Abdelaal Eltigani , Machaalany Jimmy , Rodés‐Cabau Josep , Rinfret Stéphane , Déry Ugo , Costerousse Olivier , Roy Louis , Bertrand Olivier F. 
Published: October 2012

ObjectivesTo determine the prevalence of a concurrent CTO in men and women and to examine its impact on mortality.BackgroundThe impact of chronic total occlusion (CTO) in patients with ST‐elevation myocardial infarction (STEMI) according to gender has not been assessed.MethodsPatients referred with STEMI were categorized into single vessel disease (SVD), multivessel disease (MVD) without, with 1 or > 1 CTO. The primary end‐point was the 1‐year mortality.ResultsAmong the 2020 STEMI patients included between 2006 and 2011, 24% were female. Women were older, had more hypertension and renal failure (P < 0.0001 for all). The prevalence of 1 or > 1 concurrent CTO was similar in both sexes, 7 and 1%, respectively. Early and late mortality was significantly higher in women compared with men (P < 0.0001). In women, the mortality was significantly worse in patients with > 1 CTO (100%) and with 1 CTO (36.4%) compared with those with MVD without CTO (18.4%) or with SVD (10.4%) (P < 0.0001). MVD with and without concurrent CTO were both independent predictors of 1‐year mortality in women (HR 3.58; 95 % CI 1.69–7.18 and HR 2.76; 95 % CI 1.33–5.51) whereas only MVD with CTO was predictive in men (HR 2.19; 95% CI 1.20–3.97).ConclusionsAmong unselected STEMI patients, the prevalence of CTO was equal in both sexes whereas early and late mortality remained significantly higher in women. Other factors than the presence of a concurrent CTO must be explored to explain differences in survival after STEMI between women and men. © 2013 Wiley Periodicals, Inc.
Is euroscore II better than EuroSCORE in predicting mortality after transcatheter aortic valve implantation?
Authors: Watanabe Yusuke , Hayashida Kentaro , Lefèvre Thierry , Chevalier Bernard , Hovasse Thomas , Romano Mauro , Garot Philippe , Farge Arnaud , Donzeau‐Gouge Patrick , Bouvier Erik , Cormier Bertrand , Morice Marie‐Claude 
Published: October 2012

ObjectivesThe purpose of this study was to examine the performance of the European system for cardiac operative risk evaluation II (ESII) in patients undergoing transcatheter aortic valve implantation (TAVI).BackgroundThe ESII was developed recently to improve the predictive value of the original logistic EuroSCORE (LES).MethodsBetween October 2006 and November 2011, 453 consecutive patients with severe aortic stenosis undergoing TAVI with either the Edwards valve or the Corevalve were included in the current analysis. The performance of the ESII, LES, and society of thoracic surgeons predicted risk of mortality score (STS) was evaluated.ResultsMean age was 83.1 ± 6.4 years. The Edwards valve was used in 382 patients (84.3%) of the cohort, transfemoral approach (TF) in 55.0%, transapical approach (TA) in 25.2%, transaortic approach (TAo) 17.8%, transsubclabian approach (SC) 2.0%. The observed 30‐day mortality was 12.6% (11.2, 18.4, 7.4, and 22.2% for TF, TA, TAo, SC, respectively). The mean LES, STS, and ESII were 22.4 ± 12.1, 8.1 ± 6.0, and 8.1 ± 5.2, respectively. The Hosmer–Lemeshow test showed ESII was inadequately calibrated for 30‐day mortality compared with other risk scores (ESII P = 0.09, LES P = 0.84, STS P = 0.34). By using the area under the receiver operating characteristic curve (AUC), ESII better predicted 30‐day mortality, albeit poorly, compared to LES and STS (AUC = 0.68, 0.65, and 0.60, respectively). In the TF cohort, ESII was better in predicting 30‐day mortality compared to LES and STS (AUC = 0.74, 0.61, 0.60, respectively).ConclusionsAlthough the ESII demonstrated better predictive performance especially in the TF cohort, ESII is still inadequate in predicting mortality after TAVI as are LES and STS. © 2013 Wiley Periodicals, Inc.
Candidates for transcatheter aortic valve replacement
Authors: Babcock Michael J. , Lavine Steven , Strom Joel A. , Bass Theodore A. , Guzman Luis A. 
Published: October 2012

ObjectivesTo determine an estimate patient volume with severe AS meeting PARTNER‐B criteria, with the objective of providing insights into the annual volume needed to sustain a TAVR program.BackgroundWhile the prevalence of AS is well documented, potential TAVR candidates remains less established. A better understanding of this population is critical for the development of TAVR programs. Though no clear volume has been determined, societies suggest a minimum of 20–24 annual cases to establish a TAVR program.MethodsA total of 21,652 patients were screened from a single center echocardiography registry over a 3‐year period. From them, 833 patients with AS were identified representing our study population. Severity was stratified by echocardiographic criteria. Those identified to have moderate‐to‐severe and severe AS were further investigated to determine clinical status and surgical candidacy. Nonsurgical candidates were cross referenced with the PARTNER‐B exclusion criteria to determine eligibility for TAVR.ResultsSymptomatic AS was present in 133 patients (16%). Fifty (38%) were considered nonsurgical candidates. Nonsurgical patients had higher STS score (11.1 ± 10.8 vs. 4.0 ± 3.3, P < 0.001). After applying PARTNERS‐B exclusion criteria, only 18 patients (14%) were considered TAVR candidates. These findings indicate that to meet the recommended annual volume of 20–24 TAVR cases, a minimum of 150–170 symptomatic severe AS patients are required.ConclusionIn real world clinical practice, the prevalence of AS meeting PARTNERS‐B criteria for TAVR can be low. These findings suggest that either high volume valvular centers or regional referral centers will need to be considered as part of the strategy to incorporate this new technology into clinical practice. © 2012 Wiley Periodicals, Inc.
Alkylaminosilane‐Assisted Simultaneous Etching and Growth Route to Synthesise Metal Nanoparticles Encapsulated by Silica Nanorattles
Authors: Wu Xiaoli , Tan Longfei , Chen Dong , He Xiaolong , Liu Huiyu , Meng Xianwei , Tang Fangqiong 
Published: October 2012

AbstractAn efficient and facile method to synthesise silica nanorattles with multiple noble metal (Au and Pd) cores by a simultaneous etching and growth route has been developed. In this strategy, a dual‐functional alkylaminosilane was adopted to form the middle layer of solid organic–inorganic hybrid solid‐silica spheres (HSSSs), which enabled the selective etching of the middle hybrid layer of the HSSSs and the in situ growth of metal nanoparticles (NPs) inside the cavity in a one‐step hydrothermal reaction. By adjusting the pH values of the reaction system, the metal NPs could be grown exclusively inside the silica nanorattles, resulting in a high atomic utilisation of the noble metals. The size and number of Au cores were tunable by manipulating the initial concentration of HAuCl4. The prepared silica nanorattles with Au cores were successfully applied to the catalytic reduction of 4‐nitrophenol and showed high catalytic activity and cycle stability. Catalysts with multiple gold cores exhibited superior catalytic activity to those with a single gold core, probably because they possess smaller Au cores with greater surface area.
The Role of Pd2+/Pd0 in Hydrogenation by [Pd(2‐pymo)2]n: An X‐ray Absorption and IR Spectroscopic Study
Authors: Schuster Sabine , Klemm Elias , Bauer Matthias 
Published: October 2012

AbstractThe metal–organic framework (MOF) [Pd(2‐pymo)2]n (2‐pymo=2‐pyrimidinolate) was used as catalyst in the hydrogenation of 1‐octene. During catalytic hydrogenation, the changes at the metal nodes and linkers of the MOF were investigated by in situ X‐ray absorption spectroscopy (XAS) and IR spectroscopy. With the help of extended X‐ray absorption fine structure and X‐ray absorption near edge structure data, Quick‐XAS, and IR spectroscopy, detailed insights into the catalytic relevance of Pd2+/Pd0 in the hydrogenation of 1‐octene could be achieved. Shortly after exposure of the catalyst to H2 and simultaneously with the hydrogenation of 1‐octene, the aromatic rings of the linker molecules are hydrogenated rapidly. Up to this point, the MOF structure remained intact. After completion of linker hydrogenation, the linkers were also protonated. When half of the linker molecules were protonated, the onset of reduction of the Pd2+ centers to Pd0 was observed and the hydrogenation activity decreased, followed by fast reduction of the palladium centers and collapse of the MOF structure. Major fractions of Pd0 are only observed when the hydrogenation of 1‐octene is almost finished. Consequently, the Pd2+ nodes of the MOF [Pd(2‐pymo)2]n are identified as active centers in the hydrogenation of 1‐octene.
Nanosheet‐Enhanced Asymmetric Induction of Chiral α‐Amino Acids in Catalytic Aldol Reaction
Authors: Zhao Li‐Wei , Shi Hui‐Min , Wang Jiu‐Zhao , He Jing 
Published: October 2012

AbstractAn efficient ligand design strategy towards boosting asymmetric induction was proposed, which simply employed inorganic nanosheets to modify α‐amino acids and has been demonstrated to be effective in vanadium‐catalyzed epoxidation of allylic alcohols. Here, the strategy was first extended to zinc‐catalyzed asymmetric aldol reaction, a versatile bottom‐up route to make complex functional compounds. Zinc, the second‐most abundant transition metal in humans, is an environment‐friendly catalytic center. The strategy was then further proved valid for organocatalyzed metal‐free asymmetric catalysis, that is, α‐amino acid catalyzed asymmetric aldol reaction. Visible improvement of enantioselectivity was experimentally achieved irrespective of whether the nanosheet‐attached α‐amino acids were applied as chiral ligands together with catalytic ZnII centers or as chiral catalysts alone. The layered double hydroxide nanosheet was clearly found by theoretical calculations to boost ee through both steric and H‐bonding effects; this resembles the role of a huge and rigid substituent.
Distinct expression patterns of Sulf1 and Hs6st1 spatially regulate heparan sulfate sulfation during prostate development
Authors: Buresh‐Stiemke Rita A. , Malinowski Rita L. , Keil Kimberly P. , Vezina Chad M. , Oosterhof Arie , Van Kuppevelt Toin H. , Marker Paul C. 
Published: October 2012

AbstractBackground: Prostate morphogenesis initiates in the urogenital sinus (UGS) with epithelial bud development. Sulfatase‐1 (SULF1) inhibits bud development by reducing extracellular heparan sulfate (HS) 6‐O sulfation and impairing FGF10 signaling by means of the ERK1/2 mitogen activated kinases. Results: We characterized the expression patterns of HS 6‐O sulfation modifying enzymes in the developing prostate by in situ hybridization and showed that Sulf1 and Hs6st1 had overlapping but distinct expression domains. Notably, Hs6st1 was present while Sulf1 was excluded from the tips of elongating epithelial buds. This predicted relatively high HS 6‐O sulfation at the tips of elongating epithelial buds that was confirmed by immunohistochemistry. The pattern of Sulf1 expression in the peri‐mesenchymal epithelium matched predicted locations of bone morphogenetic protein (BMP) signaling. Exogenous BMP4 and BMP7 induced Sulf1 expression in the UGS, decreased epithelial HS 6‐O sulfation, and reduced ERK1/2 activation in response to FGF10. Conclusions: These data suggest that BMPs limit FGF10 action in the developing prostate at least in part by inducing Sulf1. Developmental Dynamics, 2012. © 2012 Wiley Periodicals, Inc.
Spatio‐temporal expression of HOX genes in human hindgut development
Authors: Illig Romana , Fritsch Helga , Schwarzer Christoph 
Published: October 2012

AbstractBackground:
Hox genes belong to a highly conserved subgroup of the homeobox gene superfamily. Studies of animal models have emphasized their role in defining the body plan by their coordinated expression along the body axis during ontogeny. Although an important role of HOX genes in human development is assumed, little is known about their expression during human ontogenesis. Therefore, we investigated the expression of the nine most posterior members of the HOXA, HOXB, HOXC, and HOXD clusters in embryonic hindgut between weeks 6 to 12 and in adult rectal tissue. Results: Applying in situ hybridization and immunohistochemistry, we observed expression of HOXA11, HOXA13, HOXD12, and HOXD13 in developmental week 6. However, expression of HOXD12 faded during weeks 7 and 8, and then became increasingly re‐expressed during week 9 in humans. With the exception of HOXD13, all expressed HOX genes dropped below detection limits in week 11. Adult rectal tissue displayed distinct HOXA11, HOXA13, HOXD12, and HOXD13 expression patterns within the rectal layers. Conclusions: Our data suggest a strict spatio‐temporal regulation of HOX gene expression during human development, supporting the idea of their role as key regulators. Nonetheless, the expression pattern of distinct HOX genes differs markedly from animal models. Developmental Dynamics 242:53–66, 2013. © 2012 Wiley Periodicals, Inc.
In vitro oocyte culture‐based manipulation of zebrafish maternal genes
Authors: Nair Sreelaja , Lindeman Robin E. , Pelegri Francisco 
Published: October 2012

AbstractIn animals, females deposit gene products into developing oocytes, which drive early cellular events in embryos immediately after fertilization. As maternal gene products are present before fertilization, the functional manipulation of maternal genes is often challenging to implement, requiring gene expression or targeting during oogenesis. Maternal expression can be achieved through transgenesis, but transgenic approaches are time consuming and subject to undesired epigenetic effects. Here, we have implemented in vitro culturing of experimentally manipulated immature oocytes to study maternal gene contribution to early embryonic development in the zebrafish. We demonstrate phenotypic rescue of a maternal‐effect mutation by expressing wild‐type product in cultured oocytes. We also generate loss‐of‐function phenotypes in embryos through either the expression of a dominant‐negative transcript or injection of translation‐blocking morpholino oligonucleotides. Finally, we demonstrate subcellular localization during the early cell divisions immediately after fertilization of an exogenously provided maternal product fused to a fluorescent protein. These manipulations extend the potential to carry out genetic and imaging studies of zebrafish maternal genes during the egg‐to‐embryo transition. Developmental Dynamics 242:44–52, 2013. © 2012 Wiley Periodicals, Inc.
Season of birth bias and anorexia nervosa: Results from an international collaboration
Authors: Winje Eirin , Torgalsbøen Anne‐Kari , Brunborg Cathrine , Lask Bryan 
Published: October 2012

AbstractObjective:Based on inconsistent findings in the literature, this study tested the hypothesis that “there is a season of birth bias for females with anorexia nervosa (AN).”Method:Females with AN, born in 1975 to 1996, were compared to females born in the same years and geographical regions by chi‐square test for contingency tables with known population parameter testing for monthly deviations. Five groups were based on a priori power calculation and geographical location: Iceland, Norway and Sweden (N = 847), United Kingdom (N = 706), Oregon, USA (N = 394), Argentina and Brazil (N = 486), and Australia (N = 381).Results:The hypothesis was not supported in any of the groups. The associations (Cramér's V) between month of birth and the differences in distributions of births ranged from 0.05 to 0.08, none of which were statistically significant.Discussion:The main implication of these findings is that season of birth may not play a significant part in the aetiology of AN. © 2012 by Wiley Periodicals, Inc. (Int J Eat Disord 2013;)
A Geographic Information Systems (GIS)‐based analysis of modern South African rodent distributions, habitat use, and environmental tolerances
Authors: Campbell Timothy L. , Lewis Patrick J. , Thies Monte L. , Williams Justin K. 
Published: October 2012

AbstractGoals of this study were to: (1) develop distributional maps of modern rodent genera throughout the countries of South Africa, Lesotho, and Swaziland by georeferencing museum specimens; (2) assess habitat preferences for genera by cross‐referencing locality position with South African vegetation; and (3) identify mean annual precipitation and temperature range where the genera are located. Conterminous South Africa including the countries of Lesotho and Swaziland Digital databases of rodent museum specimens housed in the Ditsong National Museum of Natural History, South Africa (DM), and the Division of Mammals, National Museum of Natural History, Smithsonian Institution, United States (NMNH), were acquired and then sorted into a subset of specimens with associated coordinate data. The coordinate data were then used to develop distributional maps for the rodent genera present within the study area. Percent habitat occupation and descriptive statistics for six climatic variables were then determined for each genus by cross‐referencing locality positions with vegetation and climatic maps. This report presents a series of maps illustrating the distribution of 35 rodent genera based on 19,471 geo‐referenced specimens obtained from two major collections. Inferred habitat use by taxon is provided for both locality and specimen percent occurrence at three hierarchical habitat levels: biome, bioregion, and vegetation unit. Descriptive statistics for six climatic variables are also provided for each genus based on locality and specimen percent incidence. As rodent faunas are commonly used in paleoenvironmental reconstructions, an accurate assessment of rodent environmental tolerance ranges is necessary before confidence can be placed in an actualistic model. While the data presented here represent only a subset of the modern geographic distributions for many of the taxa examined, a wide range of environmental regimes are observed, suggesting that more research is necessary in order to accurately reconstruct an environmental signature when these taxa are found in the fossil record.
Economic Localization Revisited
Authors: Frankova Eva , Johanisova Nadia 
Published: October 2012

ABSTRACTThe concept of economic localization, although receiving increasing academic and practical interest, still lacks a solid theoretical background. Our aim here is to suggest a working definition of the term economic localization and to outline its possible interpretations and operationalizations. Based on a detailed analysis of six monographs on the subject, we: (i) summarize the content of localization narratives as presented by the individual authors, capturing the variability of the localization agenda; (ii) present 11 localization dimensions and 17 more concrete aspects of localization arguments as a way to structure and operationalize the concept; and (iii) suggest a condensed working definition of the economic localization concept. We argue that it is crucial to acknowledge the complexity of the economic localization agenda, which should not simply focus only on some of its aspects without keeping a sense of the whole in mind. We thus propose to define economic localization as both the process and the result of moral, political and practical support of as many localized aspects of production and consumption as possible and desirable. Finally, we discuss the construction of “the other” within the localization argument, and the position of the localization concept within the research agenda of ecological economics. Copyright © 2012 John Wiley & Sons, Ltd and ERP Environment.
Green New Deal: A Green Way out of the Crisis?
Authors: Aşıcı Ahmet Atıl , Bünül Zeynep 
Published: October 2012

ABSTRACTThe multi‐dimensional nature of the current global crisis requires a holistic approach in addressing economic, social and ecological problems. Following the crisis, several organizations started to publish reports on a concept called Green New Deal (GND) with reference to the New Deal policies of the 1930s in the USA. Since then, the concept has gained increasing popularity among the public. On the other hand, it fuelled a heated discussion between its supporters and ecosocialists. The aim of this paper is to highlight the points at which GND supporters and ecosocialists converge and diverge, and discuss critically the transformative capacity of different GND proposals. We conclude that GND policies can help to set the stage for the transformation long sought by the ecosocialist agenda, and hence from this perspective, these two approaches can be seen as complementary rather than substitutes. Copyright © 2012 John Wiley & Sons, Ltd and ERP Environment.
Towards an Institutional and Historical Analysis of Environmental Policy in Madagascar
Authors: Froger Géraldine , Méral Philippe 
Published: October 2012

ABSTRACTThis article explores the application of ideas from historical institutionalism about path dependence to the study of environmental policy in Madagascar. It first reviews the central components of the historical institutionalism explanation, including the concepts of critical juncture, institutional change and institutional reproduction. This explanation is then applied to an analysis of the “diverging” trajectories of environmental policy in Madagascar during the 20th and 21th centuries. We argue that several historical and institutional events, at the national and international levels, have been critical junctures after which Malagasy environmental policy has shifted to different paths. Copyright © 2012 John Wiley & Sons, Ltd and ERP Environment.
A Multi‐level Integrated Analysis of Socio‐Economic Systems Metabolism: an Application to the Italian Regional Level
Authors: Siciliano Giuseppina , Crociata Alessandro , Turvani Margherita 
Published: October 2012

ABSTRACTIn the light of Italy's current economic stagnation, characterized by mass unemployment, especially in the south, the development of effective energy policies should be seen as an opportunity of reducing energy dependency, so as to increase competitiveness and sustainability. However, due to imbalances in development in the country, focus at the national level does not reveal particular characteristics of the different regions. In this context, the definition of specific energy actions should be based on information and analyses that refer to integrated and multi‐level perspectives, such as regional and sectoral levels. Here we investigate, by applying a multi‐scale integrated analysis of societal metabolism approach, the imbalanced nature of development, coupled with energy consumption, of two Italian regions, Veneto (northern Italy) and Abruzzo (southern Italy). Changes over time (1995–2007), related to both socio‐economic and biophysical indicators, are analysed at multiple levels: region, economic sectors, and production and consumption. The results show that different structural changes and challenges are needed to meet energy efficiency, depending on the diverse level of regional development. They provide support for the future development of effective Regional Energy Plans, as well as to identify potential local barriers to achieving regional competitiveness and sustainability. Copyright © 2012 John Wiley & Sons, Ltd and ERP Environment.