bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of different oil extraction techniques for Moringa Peregrina seed on its meal content of glucosinolates
Authors: Abd El-lateaf Hisham A. , Uthe Henriette 
Published: July 2024

Background

Moringa peregrina (M.P) is a multipurpose promising tree that grows widely in Asia and Africa’s tropical and subtropical regions. It is generally rich in nutrients especially oil which can be used for edible or nonedible purposes and also rich in protein. However, some anti-nutritional substances, namely glucosinolates (GSLs), remain in M.P meal preventing its utilization in animal or human feeding. These substances though good for the plant to defend against herbivores, cause deleterious effects or are even toxic to animals and humans. GSLs are the most important anti-nutritional substances in M.P seed and meal.

Objective
Accordingly, this investigation aims to use different techniques for oil extraction from M.P seed and their effect on the GSLs content of the meal remaining after oil extraction, then the meal is detoxified to be suitable for using in animal or human feeding.

Materials and methods
In this study, M.P meal was obtained as a by-product left over after oil extraction from moringa seed by different extraction procedures including (hydraulic press, screw pressing, extraction by solvent via Soxhlet, and prepress − solvent extraction at room temperature).The sinalbin, moringin, and total GSLs were determined and identified by HPLC. Detoxification of GSLs was then applied for M.P meal remaining after oil extraction by hexane, using soaking in water followed by a water-washing treatment.

Results and conclusion
The results indicated that sinalbin and moringin are the major dominant GSLs in M.P seed and meal. Moreover, the total GSLs content in the meal that remained after all different oil extraction techniques was significantly higher when compared with their content in the seed. Also, the results showed that there was a significant decrease in the level of total GSLs in M.P meal as a result of the water treatment. It decreased from 941.8±34.14 nmol/mg in defatted meal before water treatment to 23.97±18.31 nmol/mg in residues left after treatment with water for 15 min. Therefore, soaking in water followed by a water-washing treatment is the simplest and most efficient process to remove the GSLs from M.P meal to be suitable for animal feeding.
Black cumin seed oil and its nano-form ameliorate lipopolysaccharide-induced brain inflammatory injury in mice
Authors: Rashwan Hager K. , Mahgoub Shahenda , Abuelezz Nermeen Z. , Akabawy Ahmed M.A. , Nasr Ali M. , Kassab Rami B. , Amin Hatem K. 
Published: July 2024

Backgrounds and objectives
Microglia play a regulatory role in central nervous system inflammatory diseases, such as Alzheimer’s, Parkinson’s, and multiple sclerosis. Natural remedies like black cumin seeds (Nigella sativa) are rich in bioactive compounds that potentially can modulate inflammatory processes in the brain. In the current work, we studied the protective and anti-inflammatory properties of black cumin seed oil (BCSO) and its nano-form on lipopolysaccharide (LPS)-induced neurotoxicity in mice.

Materials and methods
Forty-eight mice were divided randomly into eight groups (n=6), three control groups (negative control, BCSO control, nano-BCSO control), LPS group, and four treatment groups [BCSO+LPS, nano-BCSO+LPS, indomethacin (5 mg/kg)+LPS, BCSO+indomethacin(2.5 mg/kg)+LPS]. At the end of the experiment, the brain tissues were removed for histopathological and biochemical assessments. Malondialdehyde and interleukin (IL)-10 were assessed using enzyme-linked immunosorbent assay while the gene expression of IL-6, toll-like receptor-4, brain-derived neurotrophic factor, nerve growth factor, cyclooxygenase-2, and B-cell lymphoma-2 were assessed by real-time PCR. IL-1β was quantified immunohistochemically along with the histopathological studies of the cerebral cortex of mice brains.

Results and conclusions
In our study, BCSO and its nano-form demonstrated a reduction in LPS-induced neurotoxicity, exhibiting comparable or better anti-inflammatory effects to indomethacin. These treatments significantly elevated the gene expression levels of neuroprotective factors brain-derived neurotrophic factor and nerve growth factor in LPS-treated mice. Pretreatment with BCSO and its nano-form reduced the malondialdehyde levels, in addition to gene expressions of cyclooxygenase-2, toll-like receptor-4, IL-6, and B-cell lymphoma-2. Immunohistochemical analysis indicated a decrease in IL-1β with BCSO and the lowering effect of the nano-form was superior. The histopathological studies corroborated with biochemical and molecular findings, suggesting that BCSO and its nano-form attenuated the inflammation and enhanced the microglial antioxidative and anti-inflammatory status. BCSO could enhance the anti-inflammatory activity of indomethacin, so lower doses of indomethacin with BCSO may be suggested for protecting against the adverse effects of high doses of NSAIDs as gastritis. Consequently, BCSO can serve a potential stimulatory supplement of the immunity for neurodegenerative conditions.
Extensive Extragenital Lichen Sclerosus-Like Lesions in a Patient with Junctional Epidermolysis Bullosa
Authors: Gupta Smriti , Handa Sanjeev , Chatterjee Debajyoti , De Dipankar , Mahajan Rahul 
Published: July 2024

Abstract
Epidermolysis bullosa (EB) is a heterogeneous group of genetic disorders characterized by the formation of blisters either spontaneously or at the sites of trauma. These heal with post-inflammatory hypopigmentation, scarring, or milia formation. We hereby present a child who presented with widespread hypopigmented atrophic areas, blistering at trauma-prone sites, and nail dystrophy. The significance of this particular case lies in the challenge of distinguishing between epidermolysis bullosa and bullous extragenital lichen sclerosus et atrophicus.
Evaluation of synchronous and asynchronous e-learning methods among MBBS students’ in medical institutions for medical education: An educational interventional study
Authors: Tomar Shashi Prabha , Bharti Aditi , Dwivedi Jyoti , Singh Tej Pratap , Dhakar Jagmohan Singh 
Published: July 2024

Abstract

Background:
The closure of educational institutions due to COVID-19 conditions created a situation where contact between students and teachers became almost impossible. It imposed a potential need for adopting alternative learning methods.

Objective:
The objective of this study was to carry out an evaluation of synchronous and asynchronous e-learning methods planned among MBBS students.

Materials and Methods:
An educational interventional study was carried out, including two equipotent academic potential groups of all students of phase 3 part one. Two groups were created (Group A – Synchronous and Group B – Asynchronous) and taught five sessions for each group with asynchronous and synchronous e-learning styles, and perceptions of students regarding learning style were recorded. The data were analyzed using SPSS, and paired t-test and independent t-test were used to compare responses. A descriptive analysis of responses received for perceptions of both learning on a 5-point Likert was carried out.

Results:
Despite the asynchronous group having a higher pretest mean score (33.63 ± 12.03) compared to the synchronous group (25.20 ± 10.1), the post-test mean scores revealed greater improvement in the synchronous group (82.21 ± 12.2) compared to the asynchronous group (81.08 ± 13.32). The study revealed statistically significant higher posttest scores (P < 0.001) in both groups. Asynchronous e-learning was slightly preferable for phase 3 students compared to synchronous e-learning based on the perception given by students.

Conclusion:
Online methods and teaching implemented with the right planning will definitively serve as an alternative in situations like COVID-19. Although these methods cannot replace face-to-face learning, they help develop students’ interest in new learning styles and prepare them for adverse learning conditions.
Pro-angiogenic effects of Guo Min decoction in a zebrafish model
Authors: Lu Ping-Hsun , Tung Sheng-Fen , Wen Chi-Chung , Huang Ching-Yuan , Huang Jhih-Wei , Chen Chih-Hsin , Chen Yau-Hung 
Published: July 2024

ABSTRACT

Objectives:
Guo Min decoction (GMD) is a Chinese traditional medicine that can regulate allergy-related symptoms. Although GMD treatment was reported to treat allergy-associated symptoms by regulating the immune response, the rationale between GMD treatment and angiogenesis has not been reported yet. Our objective is to investigate the angiogenesis-modulating activity of GMD.

Materials and Methods:
In this study, we used fluorescence recording, alkaline phosphatase (AP) activity staining, and real-time polymerase chain reaction (PCR) experiments to examine the effects of GMD on angiogenesis in a zebrafish model.

Results:
GMD-treated zebrafish embryos exhibited more intercapillary spaces in the caudal vein plexus (Mock: 11.1 ± 1.8 [n = 20; n: numbers of embryos]; GMD-treated: 16.2 ± 1.9 [n = 20]). AP activity staining showed that treatment with GMD and liquorice (Gan Cao, a component of GMD) induced subintestinal vein outgrowth. However, glycyrrhizin (a component of Gan Cao) had no obvious pro-angiogenic effects on zebrafish. Furthermore, real-time PCR experiments indicated that GMD exposure might be through regulating angiogenesis-related genes (cdh5, nrp1a, and flt1) expressions.

Conclusion:
Based on these observations, we proposed that GMD had pro-angiogenic activity in a zebrafish model, and it might partially be contributed by one of the components, liquorice.
Análisis del compromiso organizacional de la zona escolar primaria en el centro de Tulancingo, Hidalgo
Authors: Soto Escobedo Xanath Esmeralda , MARTINEZ MUÑOZ ENRIQUE , DZUL ESCAMILLA GRISELDA 
Published: July 2024

El presente trabajo tiene como finalidad conocer la percepción del compromiso organizacional de los docentes de nivel primaria de la zona centro escolar de Tulancingo de Bravo, Hidalgo, para realizar la investigación se utilizó una encuesta que mide la escala de compromiso organizacional en base a los estudios previos de Meyer y Allen, la cual está constituida por dos secciones, de las que la primera consta 5 preguntas que contribuyen para obtener datos generales de cada docente (edad, género, estado civil, etc) así como 18 reactivos de que van en una escala de: En total desacuerdo - Totalmente de acuerdo, con los que se conoce realmente la posición de cada uno de los maestros respecto al compromiso organizacional con la institución.
Para la realización de la investigación se tomó en cuenta a los docentes que laboran en la zona Centro en Tulancingo de Bravo, Hidalgo, que contempla 6 escuelas, 3 del turno matutino y 3 del turno vespertino. La información se obtuvo por medio de encuestas presenciales y electrónicas, durante los meses de mayo y junio del 2023.
Para el análisis de los datos obtenidos se realizó un análisis estadístico mediante el software IBM SPSS, version 22.0.
La información obtenida y analizada nos permite conocer que en base al compromiso organizacional, que está dividido en compromiso afectivo, normativo y de continuidad, el afectivo es el que cuenta con deficiencias, por lo que lo adecuado es fortalecer ese aspecto, a diferencia de los otros dos, que si cumplen de acuerdo a la escala del compromiso de Myer y Allen.
La responsabilidad social universitaria como estrategia de desarrollo de competencias en estudiantes de administración
Authors: Espinoza Sánchez Naser Adalberto , Espinoza Abril Vanessa Verónica 
Published: July 2024

La responsabilidad social universitaria – RSU en el Perú logró protagonismo en las últimas décadas, especialmente con el reconocimiento en la Ley Universitaria, N° 20220; las universidades la utilizan como estrategia de gestión interna, docencia, formación académica, e investigación; los grupos de interés son internos y externos, pero son los estudiantes los principales beneficiados, con su participación adquieren competencias y habilidades profesionales. La RSU constituye una estrategia con valor diferencial respecto a otras estrategias didácticas; porque interactúan: docentes y estudiantes, organizaciones públicas y privadas, medios de comunicación, organizaciones gremiales y consumidores, etc. Aborda problemáticas sociales, empresariales, y medioambientales. Se presenta un caso aplicativo que permite determinar el nivel de gestión de RSU y el aporte de su práctica al desarrollo de competencias en estudiantes de Administración de la Universidad Nacional de Trujillo. Adicionalmente, el estudio permitió identificar la necesidad de financiamiento para desarrollar proyectos de mayor impacto socio ambiental.
Pidana Pengawasan dalam Perspektif Pembaharuan Hukum Pidana di Indonesia.
Authors: Btr Teriyanti , Palapa Arika , Saifudin Iksan 
Published: July 2024

Tujuan dalam penelitianini adalah 1) untuk mengetahui dan menganalis bentuk formulasi pengaturan pidana pengawasan dalam upaya pembaharuan hukum pidana di Indonesia 2)untuk mengetahui dan menganalis tentang pidana pengawasan dalam perspektif pembaharuan hukum pidana apakah dapat mewujudkan tujuan pemidanaan. Metode penelitian yang digunakan adalah metode penelitian hukum normatif dan pendekatan yang digunakan adalah pendekatan perundang-undangan dan pendekatan konseptual serta pendekatan perbandingan. Analisis bahan hukum yang digunakan dalam penelitian ini dilakukan dengan cara menginterprestasikan, mengevaluasi dan menilai semua peraturan perundang-undangan serta menilai bahan-bahan hukum yang relevan. Hasil penelitian menunjukkan bahwa Pidana pengawasan berfungsi untuk melindungi pelaku dari dampak negatif adanya pidana perampasan kemerdekaan.Terhadap pelaku yang belum dikenai pidana perampasan kemerdekaan, di perkenankan untuk menikmati kebebasannya dengan menjalankan aktifitas sehari-hari secara normal di tengah masyarakat seraya memperbaiki dirinya.Terhadap pelaku yang menjalani pidana pengawasan dalam jangka waktu tertentu tersebut di awasi oleh pejabat pengawas dalam rangka melaporkan perkembangan pelaku.Terhadap pelaku, jika berkelakuan baik maka jangka waktu pengawasannya dapat di persingkat, namun jika sebaliknya hukuman dapat diperberat.Pidana pengawasan bercita-cita sebagai pelindung kepentingan individu terpidana dan kepentingan masyarakat yang menjadi arah tujuan pemidanaan modern. Agar pidana pengawasan sebagai salah satu jenis pidana yang terdapat di dalam rancangan KUHP 2017 ini dapat segera di sahkan dengan memperhatikan adanya keterdesakan adanya alternatif pidana perampasan kemerdekaan.Agar menghindari kesan bahwa pidana pengawasan bersifat lunak agar syarat dijatuhkan nya pidana pengawasan tersebut di rumuskan dalam suatu redaksional yang bersifat imperatif
Influence of Information Communication Technology on Child Education
Authors: Kimani James 
Published: July 2024

Purpose: The potential benefits of ICT integration in learning in schools have been extensively discussed in the academic literature worldwide. In recent years globally, there has been rapid expansion in integration of ICT in primary school education. Countries has further put in place many initiatives to enhance the same. Integration of Information and Communication Technology (ICT) is a critical factor in ensuring improved quality education. Despite the many benefits that are known to be brought by integrating ICT in teaching and learning, studies have shown that integration remains low especially in primary schools. The general objective of the study was to establish the influence of information communication technology on child education
Methodology: The paper used a desk study review methodology where relevant empirical literature was reviewed to identify main themes and to extract knowledge gaps.
Findings: The study found out that the influence of ICTs in learning cannot be dealt with in isolation. For technology to be effective, it must be availed to learners at the right time and place. There is need to be effective, it must be availed to learner's proximity; that is in classrooms or supposed learning environment
Recommendations: The study recommends that leaders need to adopt transformative leadership to achieve organizational performance. Organization should embrace transformational leadership and sound policies that will strengthen their position as a fundamental sector in generating human capital for the country's developmental and economic needs as well as the development of training programs in leadership skills and competences in transformational leadership for the leaders of enterprises
Keywords: Information communication technology, child education
Outcome of Awake Craniotomy at a Tertiary Care Hospital
Authors: Hamza Ejaz  , Lal Rehman  , Muhammad Mujahid Sharif  , Aisha Adalat  , Shafiq-Ur-Rehman  , Kashif Ramooz  
Published: July 2024

Objective: To evaluate the outcomes of awake craniotomy, in terms of complications and linguistic consequences at a tertiary care Hospital.
Methodology: A prospective cohort study was done at department of Neurosurgery of PIMS Islamabad, from June 2023 to March 2023. Patients aged 18 years or above, both genders, diagnoses with brain tumors (both low and high-grade gliomas) and patients who already scheduled for Awake Craniotomy as per indications and Hospital protocols were included. Following surgery, all patients were moved to the intensive care unit for overnight assessment. During surgery, the operative time was recorded. Post-surgery, patients were monitored for neurological deficits, seizures, brain swelling, hospital stay and linguistic outcomes in terms of good, average and poor. All the relevant information was entered and analyzed via SPSS version 26.
Results: Overall average age of the patients was 47.17+5.11 years, and their mean BMI was 29.12+2.96 kg/m2. Males were 16(40.0%) and females were 24 (60.0%). None of the patients found with neurological deficits or seizures, while brain swelling was observed in 23 patients (57.5%). Linguistic outcomes were uniformly positive, with all 40 patients (100%) reporting good outcomes. Mean operative time was 5.06 ± 0.80 hours, the mean Glasgow Coma Scale (GCS) score was 13.35 ± 1.20, and the average hospital stay was 6.32+1.84 days. Furthermore the brain swelling was statistically significant according to gender and operative time (p->0.05), while it was significantly high among patients with Grade II (Oligodendrogliomas) and with grade IV as pert he WHO grading (p-0.024).
Conclusion: The awake craniotomy observed to be a reliable and easily tolerated method for brain tumor removal. Individuals who underwent this treatment reported no substantial neurological abnormalities or seizures, and almost all of the cases showed good linguistic outcomes.
Effect of Stray and High Voltage Exposure on Livestock: An Overview
Authors: Parmar S T , Patel N B , Rani V D , Rao TKS 
Published: July 2024

Electricity is essential to dairy farming and electrically powered machines are used for milking, automatic feed dispensers and heated water bowls. Leakage of current from these equipments, high voltage lines or faulty connections between the electrical circuit and the earth can lead to an undesirable electrical phenomenon called stray voltage. Stray voltage is a small voltage (<10V) that can be measured between two possible contact points. Cows can sense voltages at approximately one-tenth of a human being. Humans have inherently higher body resistance than cows and generally have shoes or boots while working in barns, which further increases resistance. Consequently, humans do not feel what animals feel. Stray voltages less than 0.5 volts are considered normal. Stray voltages vary, depending on the circuits used and the amount of moisture in the soil around the grounding rod. Impact of stray currents on livestock at current 1 - 3 mA: At current 4 - 6 mA: common behavioral response such as flinching or delaying drinking water. At current > 6 mA (up to 10): Feed intake is reduced, resulting in lower meat and milk production. Common symptoms of stray voltage in cows include hesitation to enter the parlor, they may stampede or rush out of the parlor when released, cows dance or step around constantly while in the milking parlor, Normal milk letdown is interrupted, Increased milking time, Udder irritation caused by residual milk and increased somatic cell count which increases the incidence of mastitis.
A Study on the Effect of Housing on Physiological Responses of Nellore Lambs Kasala
Authors: Teja Vishnu , Sreedhar S , Chakravarthi M Kalyana 
Published: July 2024

A study was carried out to find out the effect of housing on physiological responses of Nellore Jodipi lambs under tropical environmental conditions. Thirty weaned Nellore ram lambs of 3-4 months age were selected based on body weight (average initial body weight) and randomly divided into three groups of ten animals each. The lambs in Group-I were housed with morum flooring and asbestos roofing with tree shade, while Group-II lambs were housed with morum flooring and asbestos roofing without tree shade and Group-III lambs were housed with elevated slatted flooring and galvalume roofing without tree shade. Temperature and humidity values were significantly (P<0.05) different among all the groups. Lower mean maximum temperature (°C) values were observed in group III (35.53±0.28) when compared to group I (36.22±0.27) and II (37.29±0.25) and the lower average maximum relative humidity (%) was 69.59±2.92 in group III followed by group II (69.88±2.94) and I (70.65±2.96). The mean physiological responses viz., rectal temperature, respiration rate and pulse rate were significantly (P<0.05) lower in group III (102.38±1.00°F, 26.25±1.00bpm, 69.07±1.00beats/min.) when compared to group I (102.60±1.00°F, 31.60±1.00bpm, 82.10±1.00beats/min.) and II (102.85±1.00°F, 33.56±1.00bpm, 87.08±1.00beats/min.), respectively. It was concluded that the housing system of elevated slatted flooring with galvalume roofing proved to be effective in controlling heat stress and maintaining normal physiological responses for better growth performance of Nellore ram lambs.
Health Care Practices of Jaffarabadi Buffalo Farmers in Rural Areas of Junagadh District of Gujarat, India
Authors: Dodiya V A , Sabapara G  P , Garg D  D , Odedra M D , Ahlawat A  R , Kasondra S M 
Published: July 2024

A field study was conducted in Junagadh district of Gujarat to ascertain the health care practices followed by Jaffarabadi buffalo owners and data were collected from randomly selected 320 respondents through personal interview with the help of structured interview schedule. The present study revealed that about 63.12 and 17.50 percent of the respondents regularly vaccinated their buffaloes against Foot and Mouth Disease and Haemorrhagic Septicaemia disease, respectively. None of the respondents vaccinated and tested their buffaloes against brucellosis. Only 18.13 percent of the respondents practiced deworming to their buffaloes at regular interval and followed various practices (spraying, dusting and injectable drugs) for control of ecto–parasites (81.56%) and cleaned animal sheds (76.57%). Only 22.82 percent of the respondents informed that they treated their sick buffaloes by veterinarian. All the respondents washed hind quarters of buffalo after drop of placenta. Most (83.75%) of the respondents kept diseased animals together with healthy ones and majority (70.94%) of the respondents removed the dung twice in a day from animal sheds.