bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhancing supply chain agility through information systems artifacts and process standardization: an empirical assessment
Authors: Saeed Khawaja , Malhotra Manoj , Abdinnour Sue 
Published: July 2024

Purpose
The purpose of this paper is to examine the role that information systems (IS) artifacts (IS for automation and IS for analytics) and process standardization play in enhancing different dimensions of supply chain agility (SCA) (sensing, comprehending and responding).

Design/methodology/approach
Data collected through the survey approach was used to examine the research model. The results were analyzed based on regression analysis. Various tests were conducted to validate the results of the mediation hypotheses.

Findings
The results show that IS for analytics has a significant association with all dimensions of SCA and mediates the relationship between IS for automation and SCA’s sensing and comprehending dimensions. In addition, process standardization directly and uniquely influences the comprehending and responding dimensions of SCA.

Research limitations/implications
The assessment of the relationship between different IS features in the context of SCA enhancement contributes to theory development in the area of IS-enabled supply chains. Furthermore, investing in both process and IS-related initiatives offers unique value in the context of supply chains. The data collection approach limited us to a cross-sectional analysis, whereas longitudinal data could have offered deeper insights.

Practical implications
IS artifacts and process-based initiatives can be leveraged for organizational capability enhancement. Organizations that are vigilant, analysis driven and take quick actions, invest in IS-based tools that support analytics. The highest impact of these tools is visible in the enhancement of the comprehending dimension of SCA.

Originality/value
Prior research does not explicitly examine the interplay among the different IS artifacts. Furthermore, process-centric initiatives can also be used in conjunction with or as an alternative to IS-based initiatives. The originality of this work stems from jointly evaluating the role of IS artifacts and process standardization in making the supply chain more agile.
Fostering social enterprise innovativeness: the interplay of learning, market orientation and stakeholder engagement within a capability framework
Authors: Weerakoon Chamindika , McMurray Adela J. 
Published: July 2024

Purpose
Drawing on capability theory, this study aims to examine the interplay of learning orientation, market orientation and stakeholder engagement in fostering social enterprise innovativeness.

Design/methodology/approach
A survey of 1,044 Australian social enterprise executives and managers tested hypotheses in a mediated moderation model using structural equation modelling.

Findings
Nested model comparisons revealed key insights: market orientation partially mediates the relationship between learning commitment, open-mindedness and innovativeness. High stakeholder engagement hinders learning commitment’s effect on innovativeness while enhancing open-mindedness’ impact. Shared vision negatively affects innovativeness. Control variables highlight gender-based perceptions, with female executives viewing market orientation and innovativeness less favourably than male counterparts. This study underscores the importance of heightened market orientations in hostile business environments.

Research limitations/implications
Findings prompt further investigation into stakeholder engagement’s negative impact on learning commitment and shared vision’s effect on innovativeness. It is crucial to recognise gender perspectives in strategy and align internal practices with external conditions.

Originality/value
This study clarifies the interplay between learning orientation, market orientation and stakeholder engagement in fostering innovativeness amid contradictory findings. It advances social enterprise research by introducing a capability-based approach to cultivate innovativeness, challenging dominant customer-focused strategies to enhance organisational performance.
Fracture network characterization through fractal dimension and Gutenberg–Richter parameter: Decatur open‐source dataset as a study case
Authors: Pavez‐Orrego Claudia , Pastén Denisse , Estay Rodrigo 
Published: July 2024

AbstractThe fractal formalisms are well known for providing new understandings regarding the geometrical, spatial, and temporal behaviour of seismicity. Particularly, the fractal dimensions give information about the seismic events self‐organization and self‐similarity. On the other hand, the Gutenberg–Richter value, known as the b‐value, has shown through the years to give handy information regarding the statistical distribution of earthquakes, on‐site physical parameters, and geomechanical inputs. The Gutenberg–Richter value (b) and the capacity and correlation fractal dimensions, (D0 and D2), of the spatial distribution of earthquake hypocentres interact mathematically for micro‐ and macro‐events. From this interaction, it is possible to obtain new insights into the fracture network development and the microseismicity source characterization in terms of single fractures, fault planes, or densely fractured volumetric spaces. Here we show this interaction for the open‐source Decatur CO2 project seismicity catalogue, comparing it with the results obtained for a natural earthquake catalogue of Illinois, in the United States. The fractal dimension D0 is calculated using two different methodologies: box‐counting and correlation integral partitioning. This last method is also used to calculate D2. The results presented in this study allow us to describe how the fracture network geometry influences the earthquake complexity. Together with the calculation of the b‐value, we present clear indications which show that seismicity recorded in the Illinois tectonic environment partially follows the Aki relationship D0 ∼ 2b, which is not the case for induced events. In addition, the induced earthquake dataset shows that D2 > D0, an anomalous behaviour in terms of the fractal formalisms. All these facts might be used to establish spatial fracture network control techniques and seismicity‐type distinctions in CO2 injection sites located in highly active tectonic areas, respectively.
Introduction: Policing the Permacrisis
Authors: Bradford Ben , Jackson Jonathan , Taylor Emmeline 
Published: July 2024

AbstractAgainst the backdrop of what seems like a perpetual cycle of crisis for policing in modern day England and Wales, this introduction synthesises some of the core challenges facing the police. A catalogue of crimes committed by serving officers, missed opportunities for reform, and a scathing review of the internal culture of the Metropolitan Police culminating in a recommendation for a ‘complete overhaul’, might initially leave some readers with the view that there is little hope for fixing an outdated and buckling police service. Yet this collection of articles, authored by academic experts, senior police—both current and former—and commentators, not only summarises some of the problems facing policing as the new Government beds in. The contributions also brim with a diverse set of ideas for changing policing for the better and rebuilding trust and confidence. We conclude with the idea that a fundamental review and reconceptualization of the police role, of the type that might be provided by a Royal Commission, is needed if we are to meet the challenges that lie ahead.
A preliminary survey of the cellular responses of the black fungus Cryomyces antarcticus to long and short‐term dehydration
Authors: Cassaro Alessia , D' Alò Federica , Pacelli Claudia , Cavalazzi Barbara , Zucconi Laura , Onofri Silvano 
Published: July 2024

AbstractThe McMurdo Dry Valleys in Southern Victoria Land, Antarctica, are known for their extreme aridity, cold, and nutrient‐poor conditions. These valleys provide a valuable comparison to environments on Mars. The survival of microorganisms in these areas hinges on their ability to withstand dehydration due to the limited availability of liquid water. Some microorganisms have adapted to survive extended periods of metabolic inactivity and dehydration, a physiological response to the harsh conditions in which they exist. This adaptation is significant for astrobiology studies as it allows for testing the resilience of microorganisms under extraterrestrial conditions, exploring the boundaries and potential for life beyond Earth. In this study, we examined the survivability, metabolic activity, cellular membrane integrity, and ultrastructural damage of Cryomyces antarcticus, a eukaryotic organism used for astrobiological studies, following two dehydration processes. We conducted a fast dehydration process, simulating what happens on the surface of Antarctic rocks under typical environmental conditions, and a slow dehydration process, which is commonly used in astrobiological experiments. Our findings revealed a higher percentage of damaged cells following slow dehydration treatments, confirming that rapid dehydration reflects the adaptability of microorganisms to respond to sudden and drastic changes in the Antarctic environment.
The Russia–Ukraine war, the evolving global order, the Global South and emergence of non‐alignment 2.0
Authors: Verma Raj , Brosig Malte 
Published: July 2024

AbstractThe conclusion to the special section argues that the Russia‐Ukraine war has led to the emergence of non‐alignment 2.0 in the Global South because the Cold War era non‐alignment is anachronistic in the current/emerging world order. Non‐alignment 2.0 is characterised by countries exercising strategic autonomy to maximise their geo‐economic, geopolitical and geostrategic interests. They are neither aligned with the West nor with non‐western powers forming a strategic alliance. Consequently, they have been unwilling to choose a side in the Russia‐Ukraine war. In non‐alignment 2.0, states in the Global South will be critical of both the West and non‐western powers including China and Russia if they are unable to provide effective solutions to their problems and will create/provide their own norms and establish their own institutions to solve the problems facing these countries. Non‐alignment 2.0 lacks coherence because it is unable to provide an effective political and economic path.
First‐attempt awake tracheal intubation success rate using a hyperangulated unchannelled videolaryngoscope vs. a channelled videolaryngoscope in patients with anticipated difficult airway: a randomised controlled trial
Authors: Taboada Manuel , Fernández Jorge , Estany‐Gestal Ana , Vidal Inma , Dos Santos Laura , Novoa Carmen , Pérez Alejandra , Segurola Javier , Franco Edgar , Regueira Julia , Mirón Paula , Sotojove Rosa , Cortiñas Julio , Cariñena Agustín , Peiteado Marcos , Rodríguez Alfonso , Seoane‐Pillado Teresa 
Published: July 2024

SummaryIntroductionThere is uncertainty about the optimal videolaryngoscope for awake tracheal intubation in patients with anticipated difficult airway. The use of channelled and unchannelled videolaryngoscopy has been reported, but there is a lack of evidence on which is the best option.MethodsWe conducted a randomised clinical trial to compare the efficacy of the C‐MAC D‐Blade® vs. Airtraq® in adult patients (aged ≥ 18 y) scheduled for elective or emergency surgery under general anaesthesia with anticipated difficult airway who required awake tracheal intubation under local anaesthesia and conscious sedation. The primary endpoint was the first‐attempt tracheal intubation success rate. Secondary outcomes included the overall success rate; number of tracheal intubation attempts; Cormack and Lehane glottic view; level of difficulty (visual analogue score); patient discomfort (visual analogue score); and incidence of complications.ResultsNinety patients (70/90 male (78%); mean (SD) age 65 (12) y) with anticipated difficult airways were randomly allocated to C‐MAC D‐Blade or Airtraq videolaryngoscopy. First‐attempt successful tracheal intubation rate was higher in patients allocated to the C‐MAC D‐Blade group compared with those allocated to the Airtraq group (38/45 (84%) vs. 28/45 (62%), respectively; p = 0.006). The proportion of patients' tracheas that were intubated at the second and third attempt was 4/45 (9%) and 3/45 (7%) in those allocated to the C‐MAC D‐Blade group compared with 14/45 (31%) and 1/45 (2%) in those allocated to the Airtraq group (p = 0.006). There was no significant difference in overall tracheal intubation success rate (C‐MAC D‐Blade group 45/45 (100%) vs. Airtraq group 43/45 (96%), p = 0.494).DiscussionIn patients with anticipated difficult airway, first‐attempt awake tracheal intubation success rate was higher with the C‐MAC D‐Blade compared with Airtraq laryngoscopy. No difference was found between the two videolaryngoscopes in overall tracheal intubation success rate.
Pre‐clinical and early clinical considerations for the development of non‐hormonal contraceptives for men
Authors: Johnston Daniel S. 
Published: July 2024

AbstractIntroductionThis manuscript presents non‐hormonal male contraceptive development in the context of mitigating risk to investigators and investors.ObjectiveThe manuscript uses examples to illustrate drug development principles to move a project from discovery to development. The content is intended for those with reproductive biology backgrounds without significant exposure to drug development—particularly early‐stage targeted drug development—and those with general interest in developing non‐hormonal methods of contraception.ConclusionThe goal of issues addressed in this manuscript is to facilitate the advancement of innovative male contraceptives into late‐stage clinical trials, while keeping in mind early recognition of program deficiencies and development of mitigation strategies, or reassignment of limited, valuable resources.
An exploration of cooperative stakeholder engagement and risk‐taking behavior in privately held family firms
Authors: Youm Yoo Na , Griffin Jennifer J. , Bryant Andrew 
Published: July 2024

AbstractThis study explores the impact of cooperative engagement with nonfamily employees, consumers, and communities on risk‐taking behavior of privately held, long‐lived family firms. We posit that cooperative relations can build and reinforce connectedness among the family and nonfamily stakeholders which, in turn, can lead to increased risk‐taking. More specifically, the increased stability from widespread cooperative nonfamily engagement will positively moderate risk‐taking behavior by amplifying the influence of family involvement in privately held family firms. Using a unique survey of long‐lived, privately held family firms, we find support for our hypotheses: cooperative engagement interacts with the essence of family involvement to amplify risk‐taking. This study contributes to the stakeholder engagement and family firm literatures and offers managerial and policy implications by underscoring the benefits of cooperative engagement as it enhances risk‐taking of family firms, a precursor of growth.
Union decline through extension of collective agreements?
Authors: Flaarønning Trond 
Published: July 2024

AbstractThis study investigates the effects of the mandatory extension of collective agreements on union membership. This relationship is investigated using a difference‐in‐differences framework on the staggered industry‐ and county‐wide introduction of mandatory extension in Norway from 2005 to 2011. The introduction of mandatory extension was championed by labour and social partners and motivated by the EU enlargement of 2004 in response to increasing labour immigration. However, mandatory extension could lead to lower union membership through free‐rider behaviour. It is therefore a question of whether the cure is worse than the problem it is supposed to solve. The results show that mandatory extension had an overall negative effect on union density in the affected industries of about −2.7 percentage points. The effect varies between the different industries but is never positive. These findings give credence to the free‐rider hypothesis, where mandatory extension is expected to lead to lower union density because there is less incentive to become a union member when workers can obtain the benefits of the collective agreement without paying the union dues. In line with the theoretical expectations, the effect is stronger where the gap between collective wage and non‐union wage is largest. However, negative effects are also present where this wage gap is small, showing that the results are valid in different contexts.
Classification systems for chronic pelvic pain in males: a systematic review
Authors: Cyr Marie‐Pierre , Nahon Irmina , Worman Rachel , Cowley David , Hodges Paul W. 
Published: July 2024

ObjectiveTo systematically review the classification systems for male chronic pelvic pain (CPP).MethodsThe Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica dataBASE (EMBASE), and Web of Science were searched. Any publication, with no restriction to publication date, was eligible. Publications had to propose a classification system for CPP in males or provide additional information of a system that had been identified. Systems were assessed with an adapted Critical Appraisal of Classification Systems tool.ResultsA total of 33 relevant publications were identified, with 22 proposing an original classification system. Systems aimed to: (i) diagnose CPP and/or differentially diagnose CPP from other conditions, (ii) differentially diagnose subtypes within CPP, or (iii) identify features that could inform underlying mechanisms and/or treatment selection. Conditions referred to as chronic prostatitis/chronic pelvic pain syndrome and interstitial cystitis/bladder pain syndrome were most represented. Clinical signs/symptoms, pathoanatomical investigations, and presumed pain mechanisms were used for classification. Quality of systems was low to moderate, implying limitations to consider for their interpretation.ConclusionsMany classification systems for CPP in males exist. Careful consideration of their intended purpose is required. Future work should examine whether outcomes for patients are improved when decisions are guided by their use.
Quercetin and taxifolin inhibits TMPRSS2 activity and its interaction with EGFR in paclitaxel‐resistant breast cancer cells: An in silico and in vitro study
Authors: Kundrapu Durga Bhavani , Chaitanya Amajala Krishna , Manaswi Kothapalli , Kumari Seema , Malla RamaRao 
Published: July 2024

AbstractTransmembrane protease/serine (TMPRSS2), a type II transmembrane serine protease, plays a crucial role in different stages of cancer. Recent studies have reported that the triggering epidermal growth factor receptor (EGFR) activation through protease action promotes metastasis. However, there are no reports on the interaction of TMPRSS2 with EGFR, especially in triple‐negative triple negative (TNBC). The current study investigates the unexplored interaction between TMPRSS2 and EGFR, which are key partners mediating metastasis. This interaction is explored for potential targeting using quercetin (QUE) and taxifolin (TAX). TMPRSS2 expression patterns in breast cancer (BC) tissues and subtypes have been predicted, with the prognostic significance assessed using the GENT2.0 database. Validation of TMPRSS2 expression was performed in normal and TNBC tissues, including drug‐resistant cell lines, utilizing GEO datasets. TMPRSS2 was further validated as a predictive biomarker for FDA‐approved chemotherapeutics through transcriptomic data from BC patients. The study demonstrated the association of TMPRSS2 with EGFR through in silico analysis and validates the findings in TNBC cohorts using the TIMER2.0 web server and the TCGA dataset through C‐Bioportal. Molecular docking and molecular dynamic simulation studies identified QUE and TAX as best leads targeting TMPRSS2. They inhibited cell‐free TMPRSS2 activity like clinical inhibitor of TMPRSS2, Camostat mesylate. In cell‐based assays focused on paclitaxel‐resistant TNBC (TNBC/PR), QUE and TAX demonstrated potent inhibitory activity against extracellular and membrane‐bound TMPRSS2, with low IC50 values. Furthermore, ELISA and cell‐based AlphaLISA assays demonstrated that QUE and TAX inhibit the interaction of TMPRSS2 with EGFR. Additionally, QUE and TAX exhibited significant inhibition of proliferation and cell cycle accompanied by notable alterations in the morphology of TNBC/PR cells. This study provides valuable insights into potential of QUE and TAX targeting TMPRSS2 overexpressing TNBC.
Epilepsy due to potential loss of ATP6V1B2 function with mechanistic insight by a Drosophila Vha55 model
Authors: Sheng Wenchao , Wang Ping , Cai Yingzi , Zhai Chaojun , Wang Hong , Zhou Feiyu , Liu Xiaoyu , Wang Leyi , Li Dong , Shu Jianbo , Cai Chunquan 
Published: July 2024

AbstractATP6V1B2 encodes the subunit of the vacuolar H+‐ATPase, which is an enzyme responsible for the acidification of intracellular organelles and essential for cell signaling and neurotransmitter release. The aim of the study is to identify the correlation between ATP6V1B2 and epilepsy. Trio‐exome sequencing was performed. Reverse Transcription‐PCR and Quantitative real‐time PCR analyses were carried out to determine whether this variant leads to nonsense‐mediated mRNA decay (NMD). Drosophila models with knocked‐down homologous genes of ATP6V1B2 were generated to study the causal relationship between the ATP6V1B2 and the phenotype of epilepsy. We described a 5‐year‐old male with a novel variant c.1163delT(p.Tyr389IlefsTer13) in ATP6V1B2, who presented with epilepsy. The expression level of the premature termination codon (PTC) transcript was normal in the patient, which indicated that NMD evasion existed in the PTC transcript. We generated an animal model using Drosophila to study the knock down effects of Vha55, which is the ATP6V1B2 ortholog in fly. The Vha55 knockdown flies show seizure‐like behaviors and climbing defects. This study expands the variation spectrum of the ATP6V1B2 gene. Cross‐species animal model demonstrates the causal relationship between ATP6V1B2 defect and epilepsy, and shed new insights into the disease mechanism caused by ATP6V1B2 LOF variants.
Bovine‐originated xenografts versus synthetic bone grafting materials in lateral maxillary sinus floor augmentation: A systematic review and meta‐analysis
Authors: Guo Tianqi , Gu Yingxin , Zhang Xiao , Ding Xinxin , Zhang Xiaomeng , Zhu Yu , Mo Jiaji , Shi Junyu , Lai Hongchang 
Published: July 2024

AbstractAimsThis study aimed to systematically compare the patients undergoing lateral MSFA therapies utilizing bovine‐originated xenografts versus varied synthetic bone grafting materials.MethodsPubmed, Scopus, Embase, and Cochrane Library were searched up to April 2023, compensated by a manual search in selected journals. Studies reporting histological outcomes (residual bone graft, newly formed bone, non‐mineralized tissue) and clinical outcomes (implant survival, ISQ value) were included. Several analyses were performed, including meta‐analysis, sensitivity study, and Egger's regression tests.ResultsSixteen clinical/randomized control trials were included in this systematic review, among which 12 were enrolled in a meta‐analysis. The percentage of newly formed bone within the grafted sinuses by hybrid HA/TCP was significantly higher than those by xenografts (WMD 2.85, 95%CI [0.72; 4.99]), but those grafted by pure HA (WMD −1.72, 95%CI [−3.15; −0.29]) or TCP (WMD −7.10, 95%CI [−13.02; −1.17]) were significantly lower than xenograft counterparts. The residual bone graft and non‐mineralized tissue yielded by synthetic HA, TCP, and HA/TCP showed no significant differences with the xenograft group.ConclusionThe chemistry of grafted bone substitutes in lateral MSFA influenced the quantity of newly formed bone. Those grafted with hybrid HA/TCP yielded the highest amount of new bone compared to bovine‐originated HA. However, this influence was not significant on residual bone graft and non‐mineralized tissue.