bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Athymic Rat Model for Mandibular Osteoradionecrosis Allowing for Direct Translation of Regenerative Treatments
Authors: Jackson Ryan S. , Voss Stephen G. , Wilson Zachary C. , Remmes Nicholas B. , Stalboerger Paul G. , Keeney Michael G. , Moore Eric J. , Janus Jeffrey R. 
Published: July 2015

ObjectiveWe aim to create a model of mandibular osteoradionecrosis in athymic rats. Athymic rats provide an immunosuppressed environment whereby human stem cells and biomaterials can be used to investigate regenerative solutions for osteoradionecrosis, bridging the gap between in vivo testing and clinical application.Study DesignProspective animal study.SettingAcademic otolaryngology department laboratory.Subjects and MethodsAfter Institutional Animal Care and Use Committee approval, 10 athymic nude rats were divided into 2 groups. The experimental group (n = 6) underwent irradiation (20 Gy), while the control group (n = 4) underwent sham irradiation catheter placement only. All 10 rats underwent extraction of the second mandibular molar 7 days later. The rats were sacrificed 28 days after dental extraction, and their mandibles were harvested. The mandibles were examined with histologic analysis and bone volume analysis based on 3‐dimensional micro–computed tomography.ResultsAll 10 rats survived the experiment period. Radiographic and histologic analysis revealed decreased bone formation in the experimental group compared with the control group. Jaw region volume ratio was 0.83 for the experimental group versus 0.97 in the control group (P =. 003). The region‐of‐interest volume ratio was 0.75 in the experimental group and 0.97 in the control group (P =. 005). Histologically, there were increased osteoclasts (P =. 02) and decreased osteoblasts (P =. 001) as well as increased fibrosis in the experimental group versus the control group.ConclusionMandibular osteoradionecrosis can be effectively and reproducibly produced in an athymic rat model. This will allow further research to study regenerative medicine in an athymic rat model.
Incidence, Degree, and Development of Graft Hypertrophy 24 Months After Matrix-Induced Autologous Chondrocyte Implantation
Authors: Ebert Jay R. , Smith Anne , Fallon Michael , Butler Rodney , Nairn Robert , Breidahl William , Wood David J. 
Published: July 2015

Background: Graft hypertrophy is a common occurrence after periosteal, collagen-covered and matrix-induced autologous chondrocyte implantation (MACI). Purpose/Hypothesis: The purpose of this study was to investigate the incidence, development, and degree of graft hypertrophy at 24 months after MACI. The hypothesis was that graft hypertrophy would not be associated with clinical outcome at 24 months. Study Design: Case series, Level of evidence, 4. Methods: This study was undertaken in 180 consecutive patients (113 male, 67 female) after MACI in the knee. All patients were assessed clinically using the Knee injury and Osteoarthritis Outcome Score (KOOS) and underwent magnetic resonance imaging (MRI) at 3, 12, and 24 months after surgery. The incidence of hypertrophy relevant to anatomic graft site was investigated, as was the progressive change in hypertrophic studies postoperatively. The degree of tissue overgrowth in hypertrophic cases was investigated, as was its association with patient clinical outcome at 24 months after surgery. Results: Of the 180 patients, 50 demonstrated a hypertrophic graft at 1 or more postoperative time points. This included 9 grafts (5.0%) at 3 months and 32 grafts (18.7%) at 12 months. At 24 months, 47 grafts (26.1%)—43 (32.1%) tibiofemoral and 4 (8.7%) patellofemoral—were hypertrophic. Patients with hypertrophic grafts at 24 months (n = 47) were younger ( P = .051), they had a lower body mass index (BMI; P = .069), and significantly fewer of them had patellofemoral grafts ( P = .007) compared with patients who had grafts with full (100%) tissue infill (n = 61). There were no significant differences in any of the KOOS subscales between patients with graft hypertrophy or full (100%) tissue infill at 24 months after surgery, while the severity of graft hypertrophy was not associated with KOOS subscales at 24 months. Conclusion: Hypertrophic grafts after MACI were common and continued to develop through to 24 months after surgery. Hypertrophic growth was associated with being younger and having a lower BMI, was more common on the femoral condyles, and overall was not associated with clinical outcome at 24 months after surgery. However, further research with longer term follow-up is required to evaluate the effect of persistent hypertrophy on graft stability and to assess the use of early surgical intervention to prevent such failure.
Unanimity overruled: Majority voting and the burden of history
Authors: Nehring Klaus , Pivato Marcus , Puppe Clemens 
Published: July 2015

Sequential majority voting over interconnected binary decisions can lead to the overruling of unanimous consensus. We characterize, within the general framework of judgement aggregation, when this happens for some sequence of decisions. The large class of aggregation spaces for which this vulnerability is present includes the aggregation of preference orderings over at least four alternatives, the aggregation of equivalence relations over at least four objects, resource allocation problems, and most committee selection problems. We also ask whether it is possible to design respect for unanimity by choosing appropriate decision sequences (independently from the ballot). Remarkably, while this is not possible in general, it can be accomplished in some interesting special cases. Generalizing and sharpening a classic result by Shepsle and Weingast, we show that respect for unanimity can indeed be thus guaranteed in the cases of the aggregation of weak preference orderings, linear preference orderings, and equivalence relations. By contrast, impossibility results can be obtained for the aggregation of acyclic relations and separable preference orderings. As a key technical tool, we introduce the notion of a covering fragment that serves as a counterpart and generalization of the notions of covering relation/uncovered set in voting theory.
Lupus Impact Tracker is responsive to physician and patient assessed changes in systemic lupus erythematosus
Authors: Giangreco D , Devilliers H , Annapureddy N , Block J A , Jolly M 
Published: July 2015

Objective To evaluate the responsiveness of Lupus Impact Tracker (LIT) to changes in physician and patient disease activity assessments over time. Methods Available longitudinal data from routine patient care visits on LIT, physician assessed disease activity (physician global assessment (PGA), SELENA-SLEDAI score, SELENA Flare Index (SFI)), and patient-reported changes in systemic lupus erythematosus (SLE) health status were analyzed. Significant, clinically important change (worsening or improvement) in physician disease activity assessment or patient-reported SLE health status were judged using the following criteria: change of 0.3 on PGA, 4 on SELENA-SLEDAI, change in SFI status over time, and change of 2 in either direction in patient-reported SLE health status. Mixed model regression analysis was used to compare changes in LIT using the above criteria. Results There were 1184 observations with significant changes in physician disease activity or patient-reported measure for 182 patients’ data across 1364 visits. Patients’ mean (SD) age and SELENA-SLEDAI were 43.5 (13.2) years and 6.4 (7.3) respectively. LIT mean scores decreased by more than 3 with improvement in PGA (standardized response mean −0.26, p < 0.05), while it increased by more than 5 with worsening in SELENA-SLEDAI (standardized response mean 0.42, p = 0.01). Mean change in LIT of greater than ±3 was noted with change in SFI status ( p < 0.05). Mean LIT score decreased by greater than 4 and increased by greater than 2 with patient-reported improvement and worsening in SLE health status respectively ( p < 0.05). Conclusions LIT is responsive to physician-assessed and patient-assessed changes in disease status. A mean LIT change of 2–4 may represent a significant clinical change in LIT. It is an effective tool that may be used by patients and physicians in tracking disease impact in SLE patients.
Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) and performance of everyday life tasks: Actual Reality
Authors: Goverover Yael , Chiaravalloti Nancy , DeLuca John 
Published: July 2015

Background: Recently, a brief cognitive assessment (Brief International Cognitive Assessment for Multiple Sclerosis: BICAMS) has been recommended for use with patients diagnosed with multiple sclerosis (MS) to screen for cognitive impairments. However, the relationship between the BICAMS and everyday life activity has not been examined. The aim of this study was to examine whether the BICAMS can predict performance of activities of daily living using Actual RealityTM (AR) in persons with MS. Method: A between-subjects design was utilized to compare 41 individuals with MS and 32 healthy controls (HC) performing BICAMS and an AR task. Participants were asked to access the internet to purchase a flight ticket or cookies, and were administered the BICAMS and questionnaires to assess quality of life (QOL), affect symptomatology, and prior internet experience. Results: Participants with MS performed significantly worse than HC on the BICAMS and the AR. Additionally, better BICAMS performance was associated with more independent AR performance. Self-reports of QOL were not correlated with AR or BICAMS performance. Conclusions: Individuals with MS have greater problems with actual everyday life tasks as compared to HC. The BICAMS is a promising cognitive screening tool to predict actual functional performance in participants with MS.
MRI-detectable cortical lesions in the cerebellum and their clinical relevance in multiple sclerosis
Authors: Favaretto Alice , Lazzarotto Andrea , Poggiali Davide , Rolma Giuseppe , Causin Francesco , Rinaldi Francesca , Perini Paola , Gallo Paolo 
Published: July 2015

Background: The demonstration of cortical lesions (CL) in the cerebellum by magnetic resonance imaging (MRI) is hampered by technical and anatomical constraints. Objective: To investigate the occurrence of cerebellar CL and their correlation with cerebellar-related disability by combining Double Inversion Recovery (DIR) and Phase Sensitive Inversion Recovery (PSIR) MRI images in multiple sclerosis (MS) patients. Material and methods: 40 MS patients (10 CIS/eRRMS, 24 RRMS, 6 SPMS), having a wide range of disability and disease duration, were enrolled. DIR and PSIR images were obtained with a 3T-MRI. Results: Cerebellar white matter lesions (WML) and/or CL were observed in 33/40 patients (82.5%) among which 14/40 had only CL. CL were demonstrated in 26/40 patients by DIR and in 31/40 by PSIR, and their number increased from CIS/eRRMS to SPMS. PSIR disclosed a significantly higher number of CL compared to DIR (RRMS: p=0.0008; SPMS: p=0.002). CL number correlates with the cerebellar Expanded Disability Status Score (EDSS) score ( r=0.72, p<0.0001). No correlation was observed between supra-tentorial and cerebellar CL. Conclusions: CL are detected by PSIR in the cerebellum of the majority of MS patients, are more than WML, increase with disease progression and strongly correlate with the cerebellar EDSS. Thus, the observation of CL in the cerebellum of MS at clinical onset might be useful for prognostic and therapeutic aims.
App-centric mobile media and commoditization: Implications for the future of the open Web
Authors: Daubs Michael S. , Manzerolle Vincent R. 
Published: July 2015

This paper traces linkages between the commoditization of the Web and what we call “app-centric media.” By this we mean a media environment composed of a multitude of discrete-but-connected software applications and their associated protocols, platforms, frameworks, and institutions. The rapid growth of app-centric media, we argue, is directly dependent on the development and commercialization of the (mobile) Internet, as well as on the business models embedded in the development of key native app platforms such as iOS and Android. The emergence of app-centric media, particularly in relation to mobile media, is having a marked effect on conceptualizations of the Web. The prevailing rhetoric concerning the development of the mobile Internet and app-centric media employs imagery of autonomy, empowerment, and independence for both the users and producers of apps. We argue that the commoditization central to the commercial development of the mobile Internet evidences a fusion of neoliberal rhetoric valorizing worker autonomy, individual empowerment, and entrepreneurial independence, with a mode of production consonant with “cognitive capitalism” (Dyer-Witheford, 2014; Vercellone, 2007). Our analysis is divided into three sections. The first looks at the early development of the mobile Internet in relation to the accumulation strategies of cognitive capitalism including the structural importance of “value networks” and the “putting-out system”; the second deals with the commercialization models underpinning the two dominant app platforms, Apple’s iOS and Android; the third addresses the development of HTML as a means of production and describes how HTML5 is framed as a prospectively more “open” competitor to the existing platform duopoly. It concludes by briefly examining the development of the Firefox OS mobile platform—and whether this platform resists or incorporates the forms of commoditization associated with app-centric media generally.
Elemental, lead and sulfur isotopic compositions of galena from
Kola carbonatites, Russia – implications for melt and mantle
evolution
Authors: Bell K. , Zaitsev A. N. , Spratt J. , Fröjdö S. , Rukhlov A. S. 
Published: July 2015

AbstractGalena from four REE-rich (Khibina, Sallanlatvi, Seblyavr,
Vuoriyarvi) and REE-poor (Kovdor) carbonatites, as well as
hydrothermal veins (Khibina) all from the Devonian Kola Alkaline Province of
northwestern Russia was analysed for trace elements and Pb and S isotope
compositions. Microprobe analyses show that the only detectable elements in
galena are Bi and Ag and these vary from not detectable to 2.23 and not
detectable to 0.43 wt.% respectively. Three distinct galena groups can be
recognized using Bi and Ag contents, which differ from groupings based on Pb
isotope data. The Pb isotope ratios show significant spread with
206Pb/204Pb ratios (16.79 to 18.99),
207Pb/204Pb (15.22 to 15.58) and
208Pb/204Pb ratios (36.75 to 38.62). A near-linear
array in a 207Pb/204Pb vs.206Pb/204Pb ratio diagram is consistent with mixing
between distinct mantle sources, one of which formed during a major
differentiation event in the late Archaean or earlier. The S isotopic
composition (δ34S) of galena from carbonatites is significantly
lighter (–6.7 to –10.3% Canyon Diablo Troilite (CDT) from
REE-rich Khibina, Seblyavr and Vuoriyarvi carbonatites,
and – 3.2% CDT from REE-poor Kovdor carbonatites) than the
mantle value of 0%. Although there is no correlation between S and any of
the Pb isotope ratios, Bi and Ag abundances correlate negatively with
δ34S values. The variations in the isotopic composition of Pb
are attributed to partial melting of an isotopically heterogeneous mantle
source, while those of δ34S (together with Bi and Ag abundances)
are considered to be process driven. Although variation in Pb isotope values
between complexes might reflect different degrees of interaction between
carbonatitic melts and continental crust or metasomatized lithosphere, the
published noble gas and C, O, Sr, Nd and Hf isotopic data suggest that the
variable Pb isotope ratios are best attributed to isotopic differences
preserved within a sub-lithospheric mantle source. Different Pb isotopic
compositions of galena from the same complex are consistent with a model of
magma replenishment by carbonatitic melts/fluids each marked by quite
different Pb isotopic compositions.
Nomenclature for the laueite supergroup
Authors: Mills S. J. , Grey I. E. 
Published: July 2015

AbstractA new nomenclature scheme has been set up for the laueite supergroup of
minerals, which have the general formula M12+M23+M33+(XO4)2(OH)2·8H2O,
where M1 = Fe2+, Mg2+ or
Mn2+; M2/M3 =
Al3+ or Fe3+; and XO4 =
PO4 or AsO4. The laueite supergroup is divided into
the laueite group (XO4 = PO4) and the
maghrebite group (XO4 = AsO4). These
groups are then subdivided into subgroups on the basis of the dominant
atoms, Al3+ or Fe3+, in octahedral sites
M2/M3. The new nomenclature has been
approved by the International Mineralogical Association Commission on New
Minerals, Nomenclature and Classification, proposal 14-F.
Magnesio-arfvedsonite from Jade Mine Tract, Myanmar: mineral description and crystal chemistry
Authors: Oberti Roberta , Boiocchi Massimo , Hawthorne Frank C. , Ball Neil A. , Harlow George E. 
Published: July 2015

AbstractMagnesio-arfvedsonite, theCFe3+-dominant analogue of eckermannite, has been found in a sample of “szechenyite” in the mineral collection of the American Museum of Natural History (AMNH H35024). It comes from the northern part of the Jade Mine Tract near Hpakan, Kachin State, Myanmar. Associated minerals are kosmochlor–jadeite solid-solution pyroxene and clinochlore. The ideal formula of magnesio-arfvedsonite isANaBNa2C(Mg4Fe3+)TSi8O22W(OH)2, and the empirical formula derived from electron microprobe analysis and single-crystal structure refinement for the sample of this work isA(Na0.96K0.04)Σ=1.00B(Na1.57Ca0.40Fe0.022+Mn0.01)Σ=2.00C(Mg4.26Fe0.192+Fe0.413+Al0.11Ti0.034+)Σ=5.00T(Si7.99Al0.01)Σ=8.00O22W[F0.02(OH)1.98]Σ=2.00. The unit-cell dimensions area= 9.867(1),b= 17.928(2),c= 5.284(1) Å, β = 103.80(2)°,V= 907.7 (2) Å3,Z= 2. Magnesio-arfvedsonite is biaxial (–), with α = 1.624, β = 1.636, γ = 1.637, all ± 0.002 and 2Vobs= 36(1)°, 2Vcalc= 32°. The ten strongest reflections in the X-ray powder pattern [dvalues (in Å),I, (hkl)] are: 2.708, 100, (151); 3.399, 68, (131); 3.144, 63, (310); 2.526, 60, (202); 8.451, 46, (110); 3.273, 39, (240); 2.167, 37, (261); 2.582, 34, (061); 2.970, 34, (221); 2.326, 33, [(251) (421)].
Crystallographic ordering of aluminium in laueite at Hagendorf-Süd
Authors: Grey I. E. , Keck E. , Mumme W. G. , MacRae C. M. , Price J. R. , Glenn A. M. , Davidson C. J. 
Published: July 2015

AbstractCrystals of laueite, Mn2+Fe23+(PO4)2(OH)2·8H2O, from the Cornelia mine open cut, Hagendorf Süd, Bavaria, are zoned due to aluminium incorporation at the iron sites, with analysed Al2O3contents varying up to 11 wt.%. Synchrotron X-ray data were collected on two crystals with different Al contents and the structures refined. The laueite structure contains two independent Fe3+-containing sites;M2 andM3, which alternate in 7 Å corner-connected octahedral chains. The coordination polyhedra are different for the two sites,M2O4(OH)2andM3O2(OH)2(H2O)2respectively. The structure refinements show that Al preferentially orders into siteM3. Refined site occupancies forM2 andM3 for the two crystals are: for crystal L-1,M2 = 0.70(1) Fe + 0.30(1) Al,M3 = 0.54(1) Fe + 0.46(1) Al and for crystal L-2,M2 = 0.67(1) Fe + 0.33(1) Al,M3 = 0.48(1) Fe + 0.52(1) Al. For crystal L-2, the octahedral chains have dominant Fe in M2, alternating with dominant Al inM3 along the chain, an ordering phenomenon not previously reported for laueite-related minerals.
Tapiaite,
Ca5Al2(AsO4)4(OH)4·12H2O,
a new mineral from the Jote mine, Tierra Amarilla, Chile
Authors: Kampf Anthony R. , Mills Stuart J. , Nash Barbara P. , Dini Maurizio , Molina Donoso Arturo A. 
Published: July 2015

AbstractTapiaite (IMA2014-024),
Ca5Al2(AsO4)4(OH)4·12H2O,
is a new mineral from the Jote mine, Tierra Amarilla, Copiapó Province,
Atacama, Chile. The mineral is a late-stage, low-temperature, secondary
mineral occurring with conichalcite, joteite, mansfieldite, pharmacoalumite,
pharmacosiderite and scorodite in narrow seams and vughs in the oxidized
upper portion of a hydrothermal sulfide vein hosted by volcanoclastic rocks.
Crystals occur as colourless blades, flattened on {101} and elongated and
striated along [010], up to ∼0.5 mm long, and exhibiting the forms {101},
{101} and {111}. The blades are commonly intergrown in subparallel bundles
and less commonly in sprays. The mineral is transparent and has a white
streak and vitreous lustre. The Mohs hardness is estimated to be between 2
and 3, the tenacity is brittle, and the fracture is splintery. It has two
perfect cleavages on {101} and {101}. The calculated density based on the
empirical formula is 2.681 g cm–3. It is optically biaxial (+)
with α = 1.579(1), β = 1.588(1), γ = 1.610(1) (white light),
2Vmeas = 66(2)° and 2Vcalc = 66°. The mineral
exhibits no dispersion. The optical orientation is X ≈
[101]; Y = b, Z ≈ [101].
The electron-microprobe analyses (average of five) provided: Na2O
0.09, CaO 24.96, CuO 0.73, Al2O3 10.08,
Fe2O3 0.19, As2O5 40.98,
Sb2O5 0.09, H2 O 23.46 (structure),
total 100.58 wt.%. In terms of the structure, the empirical formula (based
on 32 O a.p.f.u.) is (Ca4.83Cu0.102+Na0.03)Σ4.96(Al2.14Fe0.033+)Σ2.17[(As3.875+Sb0.015+)Σ3.88O16][(OH)3.76(H2O)0.24]Σ4(H2O)10·2H2O.
The mineral is easily soluble in RT dilute HCl. Tapiaite is monoclinic,
P21/n, with unit-cell
parameters a = 16.016(1), b = 5.7781(3),
c = 16.341(1) Å, β = 116.704(8)°, V =
1350.9(2) Å3 and Z = 2. The eight strongest
lines in the powder X-ray diffraction pattern are [dobs Å(I)(hkl)]:
13.91(100)(101), 7.23(17)(200,002), 5.39(22)(110,011),
4.64(33)(112,211,303), 3.952(42)(113,311,213), 3.290(35)(214,412,114,411),
2.823(39)(303,315) and 2.753(15)(513,115,121,511). The structure of tapiaite
(R1 = 5.37% for 1733 Fo > 4σF) contains
Al(AsO4)(OH)2 chains of octahedra and tetrahedra
that are topologically identical to the chain in the structure of linarite.
CaO8 polyhedra condense to the chains, forming columns, which are decorated
with additional peripheral AsO4 tetrahedra. The CaO8
polyhedra in adjacent columns link to one another by corner-sharing to form
thick layers parallel to {101} and the peripheral AsO4 tetrahedra link to
CaO6 octahedra in the interlayer region, resulting in a
framework structure.
L-selectin controls trafficking of chronic lymphocytic leukemia cells in lymph node high endothelial venules in vivo
Authors: Lafouresse Fanny , Bellard Elisabeth , Laurent Camille , Moussion Christine , Fournié Jean-Jacques , Ysebaert Loïc , Girard Jean-Philippe 
Published: July 2015

Key Points
In vivo imaging reveals that CLL cells bind to lymph node high endothelial venules via an L-selectin–dependent multistep adhesion cascade. Interference with L-selectin–mediated trafficking in high endothelial venules could limit dissemination of CLL cells to lymph nodes.