bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer Activity of Half‐Sandwich RhIII and IrIII Metalla‐Prisms Containing Lipophilic Side Chains
Authors: Gupta Gajendra , Mahesh Kumar Jerald , Garci Amine , Rangaraj Nandini , Nagesh Narayana , Therrien Bruno 
Published: March 2014

AbstractTwo hexacationic pentamethylcyclopentadienyl rhodium(III) and iridium(III) metalla‐prisms, [(η5‐C5Me5)6M6(μ3‐tpt‐κN)2(μ4‐C6HRO4‐κO)3]6+ (tpt=2,4,6‐tri‐(pyridin‐4‐yl)‐1,3,5‐triazine; R=(CH2)10CH3; M=Rh, [3]6+; M=Ir, [4]6+) isolated as their triflate salts, have been synthesised from the dinuclear complexes (η5‐C5Me5)2M2(μ4‐C6HRO4‐κO)Cl2 (M=Rh, 1; M=Ir, 2) and AgCF3SO3. The antiproliferative activity of the neutral and cationic complexes has been evaluated in vitro in human cancer cell lines. The positively charged metalla‐prisms appear to target mitochondria, which ultimately induce apoptosis in cancer cells. All biological studies suggest that the rhodium derivative [3][CF3SO3]6 possesses excellent activities, not only in vitro but also in vivo in tumour‐induced C57L6/J mice.
Influencing the Orientation of Jahn–Teller Axes in Butterfly‐Like MnIII4 Clusters
Authors: McLellan Ross , Palacios Maria A. , Brechin Euan K. , Dalgarno Scott J. 
Published: March 2014

AbstractA bis‐phenolate that has structural similarities to both calix[4]arene and the oxacalix[n]arenes provides access to a “butterfly”‐like Mn4 cluster in which all metals are in the oxidation state+3. Specific properties of this ligand, in comparison to others in the literature, offer a route to influencing the orientation of the Jahn–Teller axes within this cluster motif, which possesses a rare oxidation state arrangement.
Renewable and Functional Wood Materials by Grafting Polymerization Within Cell Walls
Authors: Cabane Etienne , Keplinger Tobias , Merk Vivian , Hass Philipp , Burgert Ingo 
Published: March 2014

AbstractA “grafting‐from” polymerization approach within and at the complex and heterogeneous macromolecular assembly of wood cell walls is shown. The approach allows for the implementation of novel functionalities in renewable and functional wood‐based materials. The native wood structure is retained and used as a hierarchical multiscale framework for a modular two‐step polymerization process. The versatility and potential of the approach is shown by a polymerization of either hydrophobic or hydrophilic and pH‐responsive monomers in the wood structure. Characterization of the modified wood reveals the presence of polymer in the cell wall, and the new properties of these wood materials are discussed.
Iron(III)‐Catalyzed Denitration Reaction: One‐Pot Three‐Component Synthesis of Imidazo[1,2‐a]pyridine Derivatives
Authors: Yan Hao , Wang Yuling , Pan Congming , Zhang Hao , Yang Sizhuo , Ren Xiaoyu , Li Jian , Huang Guosheng 
Published: March 2014

AbstractAn iron(III)‐catalyzed one‐pot three‐component cross‐coupling nitration reaction of 2‐aminopyridines, aldehydes and nitroalkanes, straightforwardly forms imidazo[1,2‐a]pyridine derivatives and is described in this report. The system shows good functional‐group tolerance and proceeds smoothly in moderate to good yields.
Construction of an Amperometric Glucose Biosensor by Immobilization of Glucose Oxidase on Nanocomposite at the Surface of FTO Electrode
Authors: Marand Zahra Rezay , Shahtahmassebi Nasser , Housaindokht Mohammad Reza , Rounaghi Golam Hossien , Razavipanah Iman 
Published: March 2014

AbstractFluorinetin oxide (FTO) nanostructure was developed on the surface of a glass plate using spray payroliziz method. A new electrochemical biosensor was fabricated based on a layer by layer process. In this process chitosanFe3O4 (CHFe3O4) nanocomposite film was prepared at the surface of FTO electrode by dipcoating method. In the next step, the glucose oxidase (GOx) was immobilized on the CHFe3O4/FTO nanocomposite electrode. The GOx/CHFe3O4/FTO bioelectrode has a linear range of 10–270 µM and a detection limit of 5 µM. The highest sensitivity was obtained at 1.2 µA mM−1 cm−2.
Cervical esophageal cancer: A population‐based study
Authors: Grass G. Daniel , Cooper S. Lewis , Armeson Kent , Garrett–Mayer Elizabeth , Sharma Anand 
Published: March 2014

ABSTRACTBackgroundThe purpose of this study was to present our analysis of outcomes, prognostic factors, and treatment for cervical esophageal carcinoma using the Surveillance, Epidemiology, and End Results (SEER) database.MethodsA query of the SEER database from 1998 to 2008 was performed for patients with nonmetastatic adenocarcinoma or squamous cell carcinoma (SCC) of the cervical esophagus. Disease‐specific survival (DSS) rates were calculated using Kaplan–Meier method, and predictive factors were analyzed by Cox proportional hazards regression.ResultsWe identified 362 patients; 92% of the patients had SCC, 16% received no definitive therapy, 5% received surgery, 71% received radiation therapy (RT), and 8% received both. Chemotherapy data were not available. Median DSS was 49 months for adenocarcinoma and 15 months for SCC. On multivariate analysis, histology (p = .02), RT (p < .001), and surgery plus RT (p < .001) were associated with DSS.ConclusionSurvival in patients with cervical esophageal carcinoma remains poor. Further studies should define the use of RT, surgery, and chemotherapy. © 2014 Wiley Periodicals, Inc. Head Neck 37: 808–814, 2015
Effects of a protein‐rich drink or a standard meal on the pharmacokinetics of elvitegravir, cobicistat, emtricitabine and tenofovir in healthy Japanese male subjects: A randomized, three‐way crossover study
Authors: Shiomi Mari , Matsuki Shunji , Ikeda Atsushi , Ishikawa Tomohiro , Nishino Noriaki , Kimura Miyuki , Irie Shin 
Published: March 2014

AbstractThis study investigated the effects of ingested food types on the pharmacokinetics of elvitegravir, cobicistat, emtricitabine, and tenofovir as a single‐tablet regimen (STR) in Japanese HIV‐negative healthy subjects. In this open‐label, randomized, three‐way crossover study, the pharmacokinetic profiles of elvitegravir, cobicistat, emtricitabine, and tenofovir were evaluated when administered with a standard breakfast, under fasting conditions, or with a nutritional protein‐rich drink. All subjects (N = 11) received a single morning dose of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (150/150/200/300 mg). Administration under fasting conditions resulted in decreases in the mean AUCinf of elvitegravir and tenofovir by 50% and 28%, respectively, relative to administration with a standard breakfast, whereas the bioavailabilities of elvitegravir and tenofovir were comparable when administered with a standard breakfast or a nutritional protein‐rich drink. Under fasting conditions, it appears that the bioavailabilities of elvitegravir and tenofovir were not equivalent to those when they were administered with either type of food, although they were bioequivalent to each other under fed conditions. Cobicistat and emtricitabine were bioequivalent under all conditions. These findings suggest that elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate should be administered with food, and that the bioavailability of elvitegravir and tenofovir is not affected by the type of meal ingested.
Prevention of gastric mucosal injury induced by anti‐platelet drugs by famotidine
Authors: Uotani Takahiro , Sugimoto Mitsushige , Nishino Masafumi , Ichikawa Hitomi , Sahara Shu , Yamade Mihoko , Iwaizumi Moriya , Yamada Takanori , Osawa Satoshi , Sugimoto Ken , Umemura Kazuo , Watanabe Hiroshi , Miyajima Hiroaki , Furuta Takahisa 
Published: March 2014

AbstractAnti‐platelet drug‐induced gastric mucosal injury correlates with intragastric pH. Our aim was to investigate prophylaxis effects of famotidine, one of the representative histamine‐2 receptor antagonists (H2RA), on gastric mucosal injury induced by dual therapy with low‐dose aspirin and clopidogrel in relation to Helicobacter pylori (H. pylori) infection and CYP2C19 genotypes. This study was conducted for 20 healthy Japanese volunteers (10 H. pylori‐positive and 10‐negative subjects) with 100 mg aspirin plus 75 mg clopidogrel (AC) once‐daily dosing and AC plus 20 mg famotidine twice‐daily dosing (ACH). Mucosal injury was endoscopically assessed on day 3 and 7 and 24‐hour intragastric pH and antiplatelet‐function test was performed on day 7. Median pH in ACH was similar between CYP2C19 extensive metabolizer (EM) and intermediate metabolizer (IM)/poor metabolizer (PM) and was significantly higher in H. pylori‐positive than negative subjects (P < .05). Mucosal injury with ACH significantly decreased in both day 3 and 7 compared with AC, irrespective with H. pylori and CYP2C19 genotypes (P < .05). Although antiplatelet effect of clopidogrel in EM was significantly higher than that in IM/PM, the additional famotidine did not affect the effect. Anti‐platelet drug‐induced gastric injury was alleviated by famotidine without attenuation of anti‐platelet functions irrespective of H. pylori and CYP2C19 genotypes.
Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease
Authors: Berg Daniela , Postuma Ronald B. , Bloem Bastiaan , Chan Piu , Dubois Bruno , Gasser Thomas , Goetz Christopher G. , Halliday Glenda M. , Hardy John , Lang Anthony E. , Litvan Irene , Marek Kenneth , Obeso José , Oertel Wolfgang , Olanow C. Warren , Poewe Werner , Stern Matthew , Deuschl Günther 
Published: March 2014

ABSTRACTWith advances in knowledge disease, boundaries may change. Occasionally, these changes are of such a magnitude that they require redefinition of the disease. In recognition of the profound changes in our understanding of Parkinson's disease (PD), the International Parkinson and Movement Disorders Society (MDS) commissioned a task force to consider a redefinition of PD. This review is a discussion article, intended as the introductory statement of the task force. Several critical issues were identified that challenge current PD definitions. First, new findings challenge the central role of the classical pathologic criteria as the arbiter of diagnosis, notably genetic cases without synuclein deposition, the high prevalence of incidental Lewy body (LB) deposition, and the nonmotor prodrome of PD. It remains unclear, however, whether these challenges merit a change in the pathologic gold standard, especially considering the limitations of alternate gold standards. Second, the increasing recognition of dementia in PD challenges the distinction between diffuse LB disease and PD. Consideration might be given to removing dementia as an exclusion criterion for PD diagnosis. Third, there is increasing recognition of disease heterogeneity, suggesting that PD subtypes should be formally identified; however, current subtype classifications may not be sufficiently robust to warrant formal delineation. Fourth, the recognition of a nonmotor prodrome of PD requires that new diagnostic criteria for early‐stage and prodromal PD should be created; here, essential features of these criteria are proposed. Finally, there is a need to create new MDS diagnostic criteria that take these changes in disease definition into consideration. © 2014 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Design of ProCAs (Protein‐Based Gd3+ MRI Contrast Agents) with High Dose Efficiency and Capability for Molecular Imaging of Cancer Biomarkers
Authors: Xue Shenghui , Qiao Jingjuan , Jiang Jie , Hubbard Kendra , White Natalie , Wei Lixia , Li Shunyi , Liu Zhi‐Ren , Yang Jenny J. 
Published: March 2014

AbstractMagnetic resonance imaging (MRI) is the leading imaging technique for disease diagnostics, providing high resolution, three‐dimensional images noninvasively. MRI contrast agents are designed to improve the contrast and sensitivity of MRI. However, current clinically used MRI contrast agents have relaxivities far below the theoretical upper limit, which largely prevent advancing molecular imaging of biomarkers with desired sensitivity and specificity. This review describes current progress in the development of a new class of protein‐based MRI contrast agents (ProCAs) with high relaxivity using protein design to optimize the parameters that govern relaxivity. Further, engineering with targeting moiety allows these contrast agents to be applicable for molecular imaging of prostate cancer biomarkers by MRI. The developed protein‐based contrast agents also exhibit additional in vitro and in vivo advantages for molecular imaging of disease biomarkers, such as high metal‐binding stability and selectivity, reduced toxicity, proper blood circulation time, and higher permeability in tumor tissue in addition to improved relaxivities.
Dual‐band CPW‐fed slot antenna for LTE and WiBro applications
Authors: Ojaroudi Nasser , Ghadimi Noradin 
Published: March 2014

ABSTRACTIn this article, we present a dual‐band coplanar waveguide‐fed slot antenna for 1.7/2.3 GHz long term evolution and wireless broadband frequencies. The proposed antenna is fabricated on an FR4 substrate with dielectric constant of 4.4. By cutting a pair of rotated T‐shaped slits in the circular radiating stub, a new resonance at the lower frequencies is generated, and also by embedding a meander‐line slit in the ground plane a good dual‐band operation antenna can be achieved. The measured impedance bandwidth for 10 dB return loss is from 1.57 to 1.73 GHz (13%) and 2.21 to 2.38 GHz (10.0%), covering the 1.7/2.3 GHz for the dual‐band wireless operations. Simulated and experimental results obtained for this antenna show that the proposed slot antenna has a good antenna gain and radiation behavior. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1013–1015, 2014
A compact CPW‐fed antenna with dual band‐notched characteristics for UWB applications
Authors: Wang Xiaochuan , Wang Liming , Zhou Heng , Lu Wenzhong 
Published: March 2014

ABSTRACTA compact CPW‐fed ultrawideband antenna with 3.9/5.5 GHz dual band‐notched characteristics is presented in this article. The antenna consists of a cup‐like radiating patch and a 50‐Ω coplanar waveguide transmission line. The dual band‐notched characteristics are obtained by etching a pair of L‐shaped slots on the edge of ground plane and introducing two symmetrical L‐shaped stubs on the radiating patch. Simulated and measured results show that the proposed antenna has a wide bandwidth from 2.5 to 11.0 GHz with stable gain and omnidirectional radiation pattern. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1047–1049, 2014
A compact fourth‐order unconditionally stable six‐stages split‐step FDTD method and numerical analysis
Authors: Kong Yong‐Dan , Chu Qing‐Xin , Li Rong‐Lin 
Published: March 2014

ABSTRACTA compact fourth‐order six‐stages split‐step finite‐difference time‐domain method is developed, which is based on the compact fourth‐order scheme. The proposed method improves the efficiency of computation by reducing the bandwidth of the matrix to be inversed from seven to five for the fourth‐order scheme. Furthermore, the proposed method is proven to be unconditionally stable. The numerical dispersion error of this new approach is studied by comparison to the original second‐order method and fourth‐order method. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1031–1036, 2014
Single‐layer standalone wideband substrate‐integrated waveguide directional coupler
Authors: Venanzoni Giuseppe , Mencarelli Davide , Morini Antonio , Farina Marco , Angeloni Giacomo , Renghini Chiara , Carta Pasquale , Potenza Paolo , Losito Onofrio , Mescia Luciano , Prudenzano Francesco 
Published: March 2014

AbstractThe design and characterization of a single‐layer wideband substrate integrated waveguide 3‐dB standalone directional coupler are described. The device exhibits a bandwidth of 2 GHz, ranging from 10.7 to 12.7 GHz, and both return loss and isolation better than 15 dB. The coupler has been built using a TACONIC RF‐35 A2 substrate. A very good agreement between simulations and experimental results is obtained. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1141–1144, 2014
Design and development of an equilateral patch sensor for determination of permittivity of homogeneous dielectric medium
Authors: Biswas Manotosh , Mandal Anirban 
Published: March 2014

ABSTRACTA simple and fast computer aided design oriented cavity model and single resonant parallel R‐L‐C circuit are proposed to design an inverted equilateral patch used as a sensor to predict the permittivity of homogeneous dielectric medium. The numerical results obtained with the present model are validated with measured results. We have also used electromagnetic softwares to validate this structure. This structure will be very useful for optimal integration of external components (active or passive devices). © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1097–1104, 2014
A miniaturized flexible surface attachable interrogator for hybrid optical fiber sensing
Authors: Ramakrishnan Manjusha , Rajan Ginu , Semenova Yuliya , Wolinski Tomasz , Domański Andrzej , Farrell Gerald 
Published: March 2014

ABSTRACTIn this article, we propose a miniaturized flexible interrogator for polarimetric and fiber Bragg grating (FBG) sensors based hybrid sensing scheme embedded in composite materials. The flexible interrogation module comprises of an arrayed waveguide (AWG) for FBG demodulation and an electro optic mach–zehnder interferometric (EO‐MZI) intensity modulator for polarimetric sensor demodulation. A customized design of AWG and EO‐MZI are presented, and the designed performance resulted in a wide channel spacing of 5 nm and low cross talk of −34 dB between adjacent channels for the AWG, and a low Vπ voltage of ±1.5 V for the MZI‐EO. The method for fabrication of the flexible interrogator device is also presented, based on post processing of platinum coated polyimide substrate. The film type interrogation module is compact, with a size of 3.4 × 0.1 × 0.01 cm3. The surface attachable flexible hybrid sensor interrogator is proposed to integrate with photo detector arrays and wireless communication technology to enhance the competency of hybrid sensing scheme in smart sensing composite parts in motion for applications in aircraft, wind rotor blades and so forth. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1167–1174, 2014
Fast uniform theory of diffraction diffraction coefficient using only one square‐root
Authors: Legendre Jean‐Francois , Marsault T. 
Published: March 2014

ABSTRACTThis article describes an uniform three‐dimensional coefficient for diffraction above a perfectly conducting wedges. Contrary to the usual form of the coefficient of Pathak and Koujoumjian, it uses a square root and simple mathematical operations to reach the result. This form is obtained by limited development around the optical transition ISB and RSB. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1238–1239, 2014
Corrections to “A stable solution of time domain electric field integral equation using weighted laguerre polynomials”
Authors: Geranmayeh Amir 
Published: March 2014

ABSTRACTCorrections to the final equations in (Chung et al., Microwave Opt Technol Lett 49 (2007), 2789–2793) are presented. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1263–1264, 2014
Design of compact broadband high gain microstrip patch antennas with modified ground plane
Authors: Mondal Kalyan , Sarkar Partha P. 
Published: March 2014

ABSTRACTThis article deals with compact microstrip patch antennas designed for broadband mobile communication covering the range from 0.88 to 5.43 GHz. The simulated results of patch antenna parameters, such as return loss, bandwidth, radiation patterns, VSWR, and gain are presented.All the antennas are fabricated using PCB etching technology. Measurements have been done using standard microwave test bench. Measured results are in good agreement with the simulated results. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1255–1259, 2014
Design of resistive double‐balanced mixer in 0.18‐μm CMOS technology with low‐power bulk‐injection technique for 5.8‐GHz DSRC applications
Authors: Huang Chien‐Chang , Changlin Guu George , Chen Chia‐Kai , Huang Chih‐Wen 
Published: March 2014

ABSTRACTThis article shows a 0.18‐µm CMOS resistive double‐balanced mixer design with low‐noise figure and high‐linearity performances, consuming only 0.21‐mW dc power, for 5.8‐GHz dedicated short‐range communications (DSRC) applications. The local oscillator (LO) signal is applied to the bulk and the source terminals differentially to reduce the required LO power without needs of impedance matching. The on‐chip central‐taped transformers are utilized as balance‐to‐unbalance function for RF and LO ports, and the differential output is used as well for intermediate‐frequency (IF) port. The measured data exhibit −8‐dB conversion gain and 8‐dB noise figure at 5.8 GHz of RF frequency and 100 MHz of IF frequency, while the input 1‐dB compression point and the input interception point in the third order (IP3) are about −7.5 and 3 dBm, respectively, to fulfill the DSRC requirements. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1248–1251, 2014
Preparation of supramolecular thermally repairable elastomer by crosslinking of maleated polyethylene‐octene elastomer with 3‐amino‐1,2,4‐triazole
Authors: Kashif Muhammad , Chang Young‐Wook 
Published: March 2014

AbstractA supramolecular thermally repairable elastomer was prepared by crosslinking of semicrystalline maleated polyethylene‐octene elastomer (mPOE) with 3‐amino‐1,2,4‐triazole (ATA) via melt mixing method. Crosslinking of mPOE with ATA induced supramolecular hydrogen bonding networks; the nature of the networks was affected by the amount of ATA, which was confirmed by Fourier transform infrared spectroscopy and X‐ray photoelectron spectroscopy. In addition, at 3 phr ATA content or above, a small number of ionic domains were observed in the tan δ curves of dynamic mechanical analysis. Dynamic mechanical analysis also showed that the storage modulus increased with increasing ATA content along with increase in the relaxation transition temperature which revealed strengthening of the network structures. Differential scanning calorimetry showed a reduction in melting temperature and degree of crystallinity of the mPOE with increasing ATA content which is attributed to hydrogen bonding networks. The shape memory property of the mPOE matrix imparted a thermal healing capability which was greatly enhanced in the presence of hydrogen bonding networks. The scratch marked on the polymer surface healed within 20 s after being heated at around 80 °C. © 2014 Society of Chemical Industry
Viscoelastic modeling of nanoindentation experiments: A multicurve method
Authors: Zhai Meiyu , McKenna Gregory B. 
Published: March 2014

ABSTRACTNanoindentation is an increasingly used method of extracting surface mechanical properties of viscoelastic materials, especially polymers. Recently, Hutcheson and McKenna used a viscoelastic contact mechanics model to analyze the contact problem between a nanosphere and polystyrene surface. In nanoindentation experiments, the ramp loading test is a similar problem to the particle embedment experiment except that the indentation load function differs. The motivation in this work is to expand the Hutcheson and McKenna analysis to the nanoindentation problem. In particular, we illustrate the limitations of analyzing only a single load‐indentation curve, which does not provide enough information to determine the full range of the viscoelastic response of a polymer, and we show that performing a test sequence that includes multiple loading rates or indentation rates spanning two or more orders of magnitude greatly improves the extracted viscoelastic properties. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2014, 52, 633–639