bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Polyanionic Topologies in Ag2VAsO6 and Ag6V2As2O13
Authors: Nuss Jürgen , Curda Jan , Jansen Martin 
Published: July 2013

Abstract
Two new silver vanadate arsenates, Ag2VAsO6 and Ag6V2As2O13, have been prepared applying high oxygen pressure syntheses in stainless-steel autoclaves. Ag2VAsO6 crystallizes in space group P1 with unit cell parameters a=639.1(1), b=646.1(1), c=706.6(1) pm, α =116.105(3), ß =91.759(4), γ = 90:067(4)°, and Z =2 (R1 =0.058, 3935 independent reflections). The structure consists of AsO4 tetrahedra and VO6 octahedra which are linked to form two-dimensional 2
¥[VAsO6]2- polyanions, separated by silver cations. Ag6V2As2O13 (C2=c, a=1895.9(2), b=536.40(6), c=1308:5(2) pm, ß =113:578(2)°, Z =4; R1 =0.030, 2571 independent reflections) displays as primary building units AsO4 tetrahedra and VO5 trigonal bipyramids which are condensed by sharing edges to one-dimensional 1
¥[V2As2O13]6- ladder-like strands, set apart by the silver cations. These heteropolyanions are without precedent
New Pulvinic Acid and Phenylalaninol Derivatives from the Mushrooms Retiboletus griseus and R. nigerrimus
Authors: Gruber Gertraud , Kerschensteiner Lydia , Marumoto Ryuji , Steglich Wolfgang 
Published: July 2013

Abstract
The close genetic relationship of the mushrooms Retiboletus griseus and R. nigerrimus is supported by the occurrence of the orange-yellow retiboletic acid, resp. its methyl ester, in both species. The structures of these highly substituted pulvinic acid derivatives have been elucidated by spectroscopic investigations. R. nigerrimus also contains two N-protocatechuyl-L-phenylalaninol derivatives, nigerrimin A and B, the first reported occurrence of such compounds in nature. Their configuration was established by the synthesis of nigerrimin B
[Cu40Se16(S-C6H4-CN)8(dppm)8]: A Disc-like Copper Cluster with a Nitrile-functionalized Ligand Shell
Authors: Langer Robert , Fenske Dieter , Fuhr Olaf 
Published: July 2013

Abstract
The new copper chalcogenide cluster [Cu40Se16(S-C6H4-CN)8(dppm)8] (1) with nitrile groups in the organic ligand shell has been synthesized and characterized by single-crystal X-ray diffraction and IR spectroscopy. The arrangement of the chalcogen atoms in 1 is similar to a close packing and is best described as two parallel layers with an ab stacking sequence. The resulting structure is a rare example of a disc-like cluster molecule
Heterometallic Complexes with Rhenium- and Iron-Bismuth Bonds
Authors: Schiwon Rafael , Metzinger Ramona , Pfirrmann Christina , Limberg Christian 
Published: July 2013

Abstract
Reaction of equimolar amounts of [Bi(OtBu)3] and [Cp2ReH] yields [Cp2Re-Bi(OtBu)2], 1, when the reaction time is kept short. Treatment of [Bi{OCH(CF3)2}3(thf)]2 with four equivalents of [Cp2ReH] leads to the heterotrinuclear complex [(Cp2Re)2Bi{OCH(CF3)2}], 4, with two Re- Bi bonds. A complex with a Bi-Fe bond was obtained in the reaction between [Cp(CO)2Fe]2 and [Bi(OAc)3]: [Cp(CO)2Fe-Bi(OAc)2], 5, was formed and found to crystallize as a dimer. The structures of 1 and 4 were also investigated
RE4B4O11F2 (RE = Pr, Nd): Two New Rare-earth Fluoride Borates Isotypic to Gd4B4O11F2
Authors: Glätzle Matthias , Huppertz Hubert 
Published: July 2013

Abstract
The rare-earth fluoride borates RE
4B4O11F2 (RE = Pr, Nd) were obtained in a Walker-type multianvil device from the corresponding rare-earth oxides and fluorides, and boron oxide. Pr4B4O11F2 was obtained under high-pressure/high-temperature conditions of 8.5 GPa=1150°C, and Nd4B4O11F2 at 8 GPa and 1300°C. The single-crystal structure determinations revealed that both compounds are isotypic to RE
4B4O11F2 (RE = Eu, Gd, Dy), crystallizing in the space group C2=c (Z = 4) with the parameters a = 1397.3(3), b = 472.78(9), c = 1400.2(3) pm, β = 91:1(1)°, V = 0.9248(3) nm3, R
1 = 0.0444, and wR
2 = 0.0539 (all data) for Pr4B4O11F2, and a = 1389.1(3), b = 471.2(1), c = 1394.4(3) pm, β = 91:1(1)°, V = 0.9125(3) nm3, R
1 = 0.0286, and wR
2 = 0.0601 (all data) for Nd4B4O11F2. The structure type of Gd4B4O11F2 contains BO4 tetrahedra as well as BO3 groups connected via common corners. Here, we report about the crystallographic characterization of both compounds in comparison to the isotypic phases and discuss their IR spectra.
NIR Absorption of Perylene Dyes and Fluorescence with Large Stokes’ Shift by Simple Deprotonation
Authors: Langhals Heinz , Rauscher Maximilian 
Published: July 2013

Abstract
A brightly red fluorescent 1-hydroxyperylene bisimide was prepared by a nucleophilic aromatic displacement reaction. The deprotonation of the hydroxy group shifts the absorption and the strong fluorescence into the NIR. A selected medium promotes an ESPT mechanism and induces a large Stokes’ shift of nearly 200 nm in the NIR
Wharton's Jelly Stem Cells: A Novel Cell Source for Oral Mucosa and Skin Epithelia Regeneration
Authors: Garzón Ingrid , Miyake Juliano , González-Andrades Miguel , Carmona Ramón , Carda Carmen , Sánchez-Quevedo María del Carmen , Campos Antonio , Alaminos Miguel 
Published: July 2013

AbstractPerinatal stem cells such as human umbilical cord Wharton's jelly stem cells (HWJSCs) are excellent candidates for tissue engineering because of their proliferation and differentiation capabilities. However, their differentiation potential into epithelial cells at in vitro and in vivo levels has not yet been reported. In this work we have studied the capability of HWJSCs to differentiate in vitro and in vivo to oral mucosa and skin epithelial cells using a bioactive three-dimensional model that mimics the native epithelial-mesenchymal interaction. To achieve this, primary cell cultures of HWJSCs, oral mucosa, and skin fibroblasts were obtained in order to generate a three-dimensional heterotypical model of artificial oral mucosa and skin based on fibrin-agarose biomaterials. Our results showed that the cells were unable to fully differentiate to epithelial cells in vitro. Nevertheless, in vivo grafting of the bioactive three-dimensional models demonstrated that HWJSCs were able to stratify and to express typical markers of epithelial differentiation, such as cytokeratins 1, 4, 8, and 13, plakoglobin, filaggrin, and involucrin, showing specific surface patterns. Electron microscopy analysis confirmed the presence of epithelial cell-like layers and well-formed cell-cell junctions. These results suggest that HWJSCs have the potential to differentiate to oral mucosa and skin epithelial cells in vivo and could be an appropriate novel cell source for the development of human oral mucosa and skin in tissue engineering protocols.
Silver‐Nitrate‐Catalyzed N‐Arylation of Amines and O‐Arylations of Phenols and Alcohols
Authors: Das Rima , Mandal Mrinmay , Chakraborty Debashis 
Published: July 2013

AbstractAn efficient and general protocol for intermolecular CN and CO cross‐coupling of amines, alcohols, and phenols with halides has been developed by using AgNO3 as the catalyst and N,N‐dimethylethylenediamine (N,N‐DMEDA) as a ligand with KOtBu as a base in a nitrogen atmosphere. A number of primary, secondary, and heterocyclic amines were coupled with various aryl iodides to give N‐arylated motifs in good to excellent yield. Along with this, several substituted phenols as well as alcohols were coupled with various halides under the same reactions condition to give O‐arylated compounds.
miR‐155 as a multiple sclerosis–relevant regulator of myeloid cell polarization
Authors: Moore Craig S. , Rao Vijayaraghava T.S. , Durafourt Bryce A. , Bedell Barry J. , Ludwin Samuel K. , Bar‐Or Amit , Antel Jack P. 
Published: July 2013

ObjectiveTo define the functional significance of increased miR‐155 expression in myeloid cells in multiple sclerosis (MS).MethodsmiR‐155 expression levels were measured in CD14+ monocytes from untreated relapsing–remitting MS patients and compared to healthy controls. Similar microRNA (miRNA) analyses were performed in laser‐captured CD68+ cells from perivascular (blood‐derived macrophages) and parenchymal (microglia) brain regions in both active MS lesions and noninflammatory cases. Using human adult blood‐derived macrophages and brain‐derived microglia, in vitro experiments were performed to demonstrate how miR‐155 influences the polarization state, phenotype, and functional properties of myeloid cells, in addition to their ability to subsequently impact adaptive T‐cell responses.ResultsIn MS, miR‐155 expression was significantly increased in both peripheral circulating CD14+ monocytes and active lesions (CD68+ cells) compared to control donor monocytes and parenchymal microglia, respectively. In vitro, miR‐155 was significantly increased in both M1‐polarized primary human macrophages and microglia. Transfection of an miR‐155 mimic increased proinflammatory cytokine secretion and costimulatory surface marker expression in both cell types; an miR‐155 inhibitor decreased proinflammatory cytokine expression. Coculture experiments demonstrated that allogeneic T‐cell responses were significantly enhanced in the presence of miR‐155–transfected myeloid cells compared to controls.InterpretationOur results demonstrate that miR‐155 regulates proinflammatory responses in both blood‐derived and central nervous system (CNS)‐resident myeloid cells, in addition to impacting subsequent adaptive immune responses. Differential miRNA expression may therefore provide insight into mechanisms responsible for distinct phenotypic and functional properties of myeloid cells, thus impacting their ability to influence CNS injury and repair. Ann Neurol 2013;74:709–720
Neubau HafenCity Universität Hamburg – Symbol für Baukunst am Wasser
Authors: Böttcher Christian , Nagel Werner 
Published: July 2013

AbstractIn Teil 2 des Berichts wird auf die Planung und Ausführung des aufgehenden Gebäudes eingegangen. Dabei stehen die konstruktiven Besonderheiten für die weitgespannten Hohlkörperdecken und die großen Auskragungen, die Komplexität des vertikalen Lastabtrages aufgrund der Vielzahl von wandartigen Trägern, die filigrane Stahlkonstruktion der Atrien und die besonderen technischen Ausrüstungen für Laborbetrieb im Vordergrund. Abschließend wird über die sich daraus ergebenen Besonderheiten in Bauablauf und Bauzustand berichtet.New building, HafenCity University Hamburg – Symbol for architecture on the waterfront – Part 2: Building constructionPart 2 of the report describes the planning and execution of the main structure for the new HafenCity University. Especially the constructive features of the wide‐span COBIAX‐slabs and the long cantilevering sections, the complexity of vertical load due to the multitude of crosswise wall‐like beams, the filigree steelwork of the foyer and the special technical equipment for university laboratories will be reported. Finally same specials of construction sequence and temporary works concerning the above mentioned specifies will be described.
Feinprofilierte UHPFRC‐Trockenfugen für Segmentbauteile
Authors: Oettel Vincent , Empelmann Martin 
Published: July 2013

AbstractGegenüber der Ortbetonbauweise hat die Segmentbauweise mit Betonfertigteilen viele Vorzüge. Diese liegen zum einen in der qualitätsgesicherten und witterungsunabhängigen Vorfertigung im Fertigteilwerk, einer verkürzten Bauzeit sowie besseren Rückbaumöglichkeiten. Des Weiteren ist der Aufwand für Bauhilfsmaßnahmen und Rüstungen wesentlich geringer und lohnintensive Arbeiten auf der Baustelle können verringert werden. Kombiniert man die Vorteile dieser Bauweise mit den exzellenten Eigenschaften von ultrahochfestem Faserbeton (UHPFRC), lassen sich filigrane und modulare Segmentkonstruktionen herstellen. Bei solchen Konstruktionen ist die Ausbildung der Segmentfugen von maßgebender Bedeutung. Am iBMB, Fachgebiet Massivbau der TU Braunschweig, wurden experimentelle und theoretische Untersuchungen zum Tragverhalten feinprofilierter UHPFRC‐Trockenfugen durchgeführt sowie ein Bemessungsansatz aufgestellt, worüber im Beitrag berichtet wird.Finely profiled UHPFRC dry joints for segmental componentsThe prefabricated segmental construction method has several advantages over the in‐situ concrete construction. The segments can be precasted under controlled conditions at the precasting yard and are not subject to weather conditions. Furthermore the construction period as well as the costs of falsework and on site can be reduced. Combining this advantageous construction method with the excellent properties of ultra high performance fiber reinforced concrete (UHPFRC), filigree and modular segmental constructions can be produced. The formation of the joints is fundamental for such constructions. Experimental and theoretical research works on finely profiled UHPFRC dry joints have been conducted at the iBMB, Department of Concrete Structures of the TU Braunschweig, and a design model has been formulated, which will be reported in the article.
Transcriptional impact of dietary methionine restriction on systemic inflammation: Relevance to biomarkers of metabolic disease during aging
Authors: Wanders Desiree , Ghosh Sujoy , Stone Kirsten P. , Van Nancy T. , Gettys Thomas W. 
Published: June 2013

AbstractCalorie restriction (CR) without malnutrition increases lifespan and produces significant improvements in biomarkers of metabolic health. The improvements are attributable in part to effects of CR on energy balance, which limit fat accumulation by restricting energy intake. Normal age‐associated increases in adiposity and insulin resistance are associated with development of a systemic proinflammatory state, while chronic CR limits fat deposition and expression of inflammatory markers. Dietary methionine restriction (MR) has emerged as an effective CR mimetic because it produces a comparable extension in lifespan. MR also reduces adiposity through a compensatory increase in energy expenditure that effectively limits fat accumulation, but essentially nothing is known about the effects of MR on systemic inflammation. Here, we review the relationships between these two interventions and discuss their transcriptional impact. In addition, using tissues from rats after long‐term consumption of CR or MR diets, transcriptional profiling was used to examine retrospectively the systems biology of 59 networks of molecules annotated to inflammation. Transcriptional effects of both diets occurred primarily in white adipose tissue and liver, and the responses to MR were far more robust than those to CR. The primary transcriptional targets of MR in both liver and white adipose tissue were phagocytes and macrophages, where expression of genes associated with immune cell infiltration and quantity was reduced. These findings support the conclusion that anti‐inflammatory responses produced by CR and MR are not strictly dependent upon reduced adiposity but are significantly influenced by the metabolic mechanisms through which energy balance is altered. © 2013 BioFactors, 40(1):13–26, 2014
The TRAIL of oncogenes to apoptosis
Authors: Oikonomou Eftychia , Pintzas Alexander 
Published: June 2013

AbstractDespite the significant advances in clinical research, surgical resection, radiotherapy and chemotherapy are still used as the primary method for cancer treatment. As compared to conventional therapies that often induce systemic toxicity and eventually contribute to tumor resistance, the TNF‐related apoptosis‐inducing ligand (TRAIL) is a promising anticancer agent that selectively triggers apoptosis in various cancer cells by interacting with its proapoptotic receptors DR4 and KILLER/DR5, while sparing the normal surrounding tissue. The intensive studies of TRAIL signaling pathways over the past decade have provided clues for understanding the molecular mechanisms of TRAIL‐induced apoptosis in carcinogenesis and identified an array of therapeutic responses elicited by TRAIL and its receptor agonists. Analysis of its activity at the molecular level has shown that TRAIL improves survival either as monotherapies or combinatorial therapies with other mediators of apoptosis or anticancer chemotherapy. Combinatorial treatments amplify the activities of anticancer agents and widen the therapeutic window by overcoming tumor resistance to apoptosis and driving cancer cells to self‐destruction. Although TRAIL sensitivity varies widely depending on the cell type, nontransformed cells are largely resistant to death mediated by TRAIL Death Receptors (DRs). Genetic alterations in cancer can contribute in tumor progression and often play an important role in evasion of apoptosis by tumor cells. Remarkably, RAS, MYC and HER2 oncogenes have been shown to sensitise tumor cells to TRAIL induced cell death. Here, we summarise the cross‐talk of oncogenic and apoptotic pathways and how they can be exploited toward efficient combinatorial therapeutic protocols. © 2013 BioFactors, 39(4):343–354, 2013
Determination of protoapigenone in rat plasma by high‐performance liquid chromatography with UV detection and its application in pharmacokinetic studies
Authors: Wei Anhua , Zhou Daonian , Wu Guanghua 
Published: July 2013

ABSTRACTA simple and sensitive HPLC method using UV detection was developed to determine the concentration of protoapigenone in rat plasma. Chromatographic separation was conducted on a C18 column with a mobile phase consisting of an acetonitrile–methanol–aqueous phase (containing 0.2% acetic acid, pH 3.0) system at a flow rate of 1.0 mL/min. The UV detector was set at 248 nm. The calibration curve was linear over the range of 0.031–10.0 µg/mL. The lower limit of quantification was 31 ng/mL. The recoveries for plasma samples ranged from 70.3 to 82.5%. The intra‐ and inter‐day accuracy and precision fulfilled the international standards. This method was successfully applied to a pharmacokinetic study of protoapigenone in rats after oral administration of protoapigenone. It was shown that protoapigenone could be absorbed rapidly after oral administration and could reach the maximum concentration within 1 h. Copyright © 2013 John Wiley & Sons, Ltd.
Determination of 3‐α‐hydroxytibolone in human plasma by LC‐MS/MS: application for a pharmacokinetic study after administration of a tibolone formulation
Authors: de Santana e Silva Cardoso Fabiana Fernandes , César Isabela Costa , Mundim Iram Moreira , de Souza Teixeira Leonardo , da Silva Enikson Pontes , Bonfim Ricardo Rodrigues , Gomes Sandro Antônio , Ferreira Denys Pires , Lopes Aderimar Rogério Batista , Pascoal Helifas Duarte , de Souza Weidson Carlo , Pianetti Gerson Antônio 
Published: July 2013

ABSTRACTA new method was developed for the quantitation of 3‐α‐hydroxy tibolone, in human plasma, after oral administration of a tablet formulation containing tibolone (2.5 mg). 3‐α‐Hydroxy tibolone was extracted by a liquid–liquid procedure, using cyproterone acetate as internal standard and chlorobutane as extraction solvent. After extraction, samples were submitted to a derivatization step with p‐toluenesulfonyl isocyanate. A mobile phase consisting of acetonitrile and water (72:28 v/v) was used and chromatographic separation was achieved using Agilent XDB C18 column (100 × 4.6 mm i.d.; 5 µm particle size), at 40°C. Mass spectrometric detection was performed using atmospheric pressure chemical ionization in negative mode for 3‐α‐hydroxy tibolone and in positive mode for cyproterone acetate. The fragmentation transitions were m/z 510.2 → m/z 170.1 and m/z 417.0 → m/z 357.1 for 3‐α‐hydroxy tibolone and cyproterone acetate, respectively. Calibration curves were constructed over the range 100–30,000 pg/mL and the method was shown to be specific, precise and accurate, with a mean recovery rate of 94.2% for 3‐α‐hydroxy tibolone. No matrix effect or carry‐over was detected in the samples. The validated method was applied in a pharmacokinetic study with a tibolone formulation in healthy female volunteers. Copyright © 2013 John Wiley & Sons, Ltd.
Uncovering the Value of Green Advertising for Environmental Management Practices
Authors: W.Y. Wong Christina , Lai Kee‐Hung , Shang Kuo‐Chung , Lu Chin‐Shan 
Published: July 2013

ABSTRACTThis paper extends previous environmental management research by building and empirically testing a model of the contingency effects of green advertising on the relationships between environmental management practices in terms of environmentally conscious manufacturing and product stewardship, environmental reputation and financial performance. We examine the value of green advertising in sharing and publicizing information about organizational achievements in environmental preservation in a business‐to business context with the Taiwanese electronics manufacturing industry. The theoretical propositions are largely confirmed by structural path analyses of survey responses collected from 122 Taiwanese electronics manufacturers. Green advertising delivers financial benefits only for those manufacturers that do not have an established environmental reputation. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment
Impact of Glomerular filtration rate on clinical outcomes after carotid artery revascularization in 11,832 patients from the CARE registry®
Authors: Gruberg Luis , Jeremias Allen , Rundback John H. , Anderson H. Vernon , Spertus John A. , Kennedy Kevin F. , Rosenfield Kenneth A. 
Published: June 2013

ObjectiveThe aim of this study was to assess the association of kidney function with carotid artery revascularization outcomes in a large contemporary database.BackgroundChronic kidney disease (CKD) is associated with increased mortality and adverse cardiovascular events after coronary intervention. There are limited data evaluating the association between CKD and adverse events among patients undergoing carotid artery revascularization procedures.MethodsThe Carotid Artery Revascularization and Endarterectomy (CARE) Registry® is a voluntary registry of 168 hospitals. Using data from the CARE Registry®, we examined registry patients undergoing carotid artery revascularization by either carotid endarterectomy (CEA) or carotid artery stenting (CAS) from May 2005 through March 2010. Patients were divided into four groups according to their glomerular filtration rate (GFR), as estimated by the Modification of Diet in Renal Disease Study Group equation using preprocedural serum creatinine levels.ResultsThe analysis included 11,832 patients who underwent carotid revascularization (6,899 CAS and 4,933 CEA). Patients with lower GFR were older, more frequently female, had more comorbidities, including hypertension, dyslipidemia, peripheral arterial disease, diabetes mellitus, chronic lung disease, ischemic heart disease, heart failure, and reduced left ventricular function, and were more likely to undergo CAS than CEA. In the overall population, CKD was associated with higher unadjusted in‐hospital and 30‐day rates of the combined endpoint of death, stroke, and myocardial infarction and the individual endpoint of stroke. After adjustment for baseline and preprocedural characteristics, CKD was not an independent predictor of adverse events in either CAS or CEA.ConclusionsPatients with CKD have a greater number of comorbidities and worse unadjusted in‐hospital and 30‐day outcomes; CKD was not, however, an independent predictor of in‐hospital and 30‐day outcomes after carotid artery revascularization. © 2013 Wiley Periodicals, Inc.