bluuebunny/crossref_metadata_2025_split huggingface dataset:
FLUCTUATING EXUDATION IN NON-NEOVASCULAR GEOGRAPHIC ATROPHY
Authors: Bottazzi Leonardo , Servillo Andrea , Zucchiatti Ilaria , Sacconi Riccardo , Querques Lea , Bandello Francesco , Querques Giuseppe 
Published: July 2024

PURPOSE:
To report a case series of exudation in non-neovascular geographic atrophy (GA), which fluctuated and spontaneously almost resolved during the follow-up.

METHODS:
A retrospective study was designed to include consecutive cases with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) associated with intraretinal fluid (IRF) but without macular neovascularization (MNV). Three eyes of 2 patients (one male, one female) were enrolled. Spectral domain optical coherence tomography (SD-OCT) and angiographies (OCT angiography and/or dye angiographies) were performed to confirm diagnosis of IRF and the absence of MNV.

RESULTS:
At baseline best-corrected visual acuity (BCVA) was between 20/50 and 20/36. SD-OCT displayed IRF in the inner and outer retinal layers with an increased central macular thickness. OCT-A and dye angiographies did not show any abnormal neovascular network. Of note, fluorescein angiography showed a leakage in correspondence of the intraretinal cysts, differently from the degenerative pseudocysts. After one month of follow-up, BCVA remained stable, while the IRF spontaneously almost resolved in all cases.

DISCUSSION:
To our knowledge, this is the first report of a fluctuating exudation in non-neovascular GA. Future studies are required to better define this potential novel clinical phenotype.
Risk Factors for Disease Progression in Glaucoma Patients With Disk Hemorrhage
Authors: Lee Ji Young , Choi Jin A. 
Published: July 2024

Précis:
Glaucoma eyes with recurrent disk hemorrhage were associated with increased systolic blood pressure and diastolic blood pressure, and increased visit-to-visit diastolic blood pressure variability was associated with glaucoma progression.

Purpose:
In this study, we investigated the effects of the clinical characteristics of disk hemorrhage (DH) and hemodynamic factors on glaucoma progression.

Methods:
This retrospective cohort study included 81 eyes with open angle glaucoma and nonrecurrent or recurrent DH. Recurrent DH was further classified according to the DH location. Visual field (VF) progression was determined using event-based analysis and Guided Progression Analysis software. The coefficient of variation (CV) of systolic blood pressure (SBP) and diastolic blood pressure (DBP) was used to measure visit-to-visit variability. Kaplan-Meier survival analysis was used to compare the cumulative risk ratio of progression between groups.

Results:
The recurrent DH group had significantly higher SBP and DBP (P=0.014 and=0.021, respectively) and a higher proportion of VF progression (P=0.019) than the nonrecurrent DH group. In particular, females with recurrent DH had the highest cumulative probability of VF progression (P=0.047, log-rank test). Recurrent DH in a different quadrant was associated with the highest cumulative probability of VF progression than nonrecurrent DH (P=0.038, log-rank test). In Cox regression analysis, higher visit-to-visit DBP variability, female gender, and recurrent DH in a different quadrant were significantly associated with glaucoma progression.

Conclusion:
In glaucomatous eyes with DH, increased visit-to-visit DBP variability was associated with glaucoma progression. Our results suggest that hemodynamic factors are involved in the recurrence of DH and progression of glaucoma.
Wipe-Out Following Gonioscopy-Assisted Transluminal Trabeculotomy Combined With Phacoemulsification
Authors: Ozmen Mehmet Cuneyt , Acar Burak , Uysal Betul Seher 
Published: July 2024

Précis:
We report a case of a 62-year-old male patient who developed a wipe-out phenomenon after uncomplicated gonioscopy-assisted transluminal trabeculotomy combined with cataract surgery.

Abstract:
A 62-year-old male patient with a diagnosis of pseudo-exfoliation and open angle glaucoma underwent uncomplicated gonioscopy-assisted transluminal trabeculotomy (GATT) combined with phacoemulsification surgery due to advanced glaucomatous damage and high intraocular pressure. Postoperative decrease in visual acuity and central visual field deterioration suggested a wipe-out phenomenon. Although the wipe-out phenomenon has been reported after other surgeries in patients with advanced glaucoma, as far as we know, this is the first report of a wipe-out phenomenon secondary to GATT combined with phacoemulsification surgery. This complication, which can lead to severe vision loss, should be considered before the surgical decision.
Neighborhood Poverty and Clinic Attendance in the Michigan Screening and Intervention for Glaucoma and Eye Health Through Telemedicine Program
Authors: Ramachandran Rithambara , Hicks Patrice M. , Lu Ming-Chen , Niziol Leslie M. , Woodward Maria A. , Elam Angela R. , Johnson Leroy , Kershaw Martha , Musch David C. , Bicket Amanda , John Denise , Killeen Olivia J. , Newman-Casey Paula Anne 
Published: July 2024

Précis:
Higher neighborhood-level poverty is associated with greater odds of missing a free eye disease screening appointment, underscoring the importance of community-based interventions to address upstream social determinants of health.

Purpose:
To investigate the association between neighborhood-level characteristics and attendance for a free eye disease screening.

Methods:
The MI-SIGHT program is conducted in 2 community clinics in Southeastern Michigan. Participant-level demographics were extracted from electronic health records. Neighborhood-level characteristics, including Area Deprivation Index (ADI), median household income (HHI), percent of households with >30% rent burden, percent of households without vehicles, percent of households in subsidized housing, and energy burden, were obtained from the Wisconsin Neighborhood Atlas and the United States census. Logistic regression was used to model the probability of clinic visit attendance, which was the main outcome measure.

Results:
One thousand four hundred thirty-one participants were scheduled for screening appointments between July 2020 and November 2021, with a no-show rate of 23%. Individuals lived an average of 7.7 miles from each clinic (SD=8.1) and in neighborhoods with a mean ADI of 6.8 (SD=3.2, 1–10 scale, where 10 is the most deprived). After adjusting for age, sex, race, and ethnicity, participants from neighborhoods with higher deprivation were more likely to have missed clinic visits. For example, there was an 8% higher odds of missed clinic visits for every 1-point increase in ADI (odds ratio, OR=1.08, P=0.020) and an 18% higher odds of a missed visit with every 10% increase in households without a vehicle (OR=1.18, P=0.013).

Conclusions:
Higher neighborhood-level poverty was associated with greater odds of missing a free eye disease screening appointment after adjusting for individual characteristics. Increased neighborhood-level resources are likely needed to bolster engagement in preventive eye care.
Awareness of Skin Cancer in the Prospective Epidemiological Research Studies in Iran Guilan Cohort Study Population
Authors: Eftekhari Hojat , Joukar Farahnaz , Faraji Niloofar , Hassanipour Soheil , Esfandyari Alireza , Naghipour Mohammadreza , Mansour-Ghanaei Fariborz 
Published: July 2024

Objectives
This study aimed to investigate the level of awareness of skin cancer among the Prospective Epidemiological Research Studies in Iran (PERSIAN) Guilan cohort study (PGCS) population.

Methods
This cross-sectional study was conducted on 625 participants of PGCS in Guilan, Iran, in 2022. The demographic and clinical information of the participants was recorded, and individuals with a history of skin cancer were excluded from the study. The awareness about skin cancer was collected using a questionnaire containing 26 questions with a cutoff score of 13 as an average score. All data were analyzed using IBM SPSS Version 21, considering a significance level < .05.

Results
Out of 625 participants, 41.84% were male. About 218 (32.9%) participants had a level of awareness about skin cancer higher than the average, in which 169 (25.5%), 276 (41.7%), 18 (2.8%), and 134 (20.2%) of participants had a higher-than-average score in epidemiology, causes, clinical manifestations, and prevention and treatment fields, respectively. The findings illustrated that the awareness score about skin cancer was significantly different based on gender, source of information on causes, and scope of clinical manifestations (p < .05). Also, the level of education and visiting a doctor could significantly affect the level of awareness (p < .05).

Conclusion
The PGCS population had low awareness of skin cancer. Identifying knowledge gaps can guide the development of targeted educational resources. Dermatology nurses can play a key role in creating and implementing health education programs that promote early detection of cancer symptoms, starting with increasing knowledge about early warning signs.
Hepatic arterial chemotherapy infusion combined with tyrosine kinase inhibitors and PD-1 inhibitors for advanced hepatocellular carcinoma with high risk: a propensity score matching study
Authors: Zuo Mengxuan , Zheng Guanglei , Cao Yuzhe , Lu Hailei , Li Da , An Chao , Fan Weijun 
Published: July 2024

Objective:
To ascertain the therapeutic efficacy and safety of FOLFOX (oxaliplatin, fluorouracil, and leucovorin)-based hepatic arterial infusion chemotherapy combined with tyrosine kinase inhibitors (TKI) and programmed cell death protein-1 inhibitors (PD-1 inhibitors) (triple therapy), as a first-line treatment in high-risk advanced hepatocellular carcinoma (aHCC with Vp4 portal vein invasion or/and tumor diameter ≥10 cm).

Methods:
This retrospective multicenter study included 466 high-risk aHCC patients treated with either triple therapy (n=245) or dual therapy (TKI and PD-1 inhibitors, n=221). The overall survival, progression-free survival, objective response rate, and safety were compared between the two groups. Propensity score matching was performed to reduce bias between the two groups.

Results:
After propensity score matching (1:1), 194 patients in each group were analyzed. The triple-therapy group showed a longer median overall survival (24.6 vs. 11.9 months; HR=0.43, P<0.001) and a longer median progression-free survival (10.0 vs. 7.7 months; HR=0.68, P=0.002) than the dual-therapy group. The survival rates at 6, 12, and 24 months were 94.2, 71.0, and 50.8% for triple therapy and 75.9, 49.9, and 26.8% for dual therapy. The objective response rate in the triple-therapy group was significantly higher (57.7 vs. 28.9%, P<0.001). In the triple-therapy group, more patients converted to non-high-risk (68.0 vs. 36.6%, P<0.001) and received salvage liver resection or ablation after downstaging conversion (16.5% vs. 9.2%, P=0.033). The grade 3/4 adverse events were 59.2 and 47.4% in the triple-therapy group and dual-therapy group, respectively (P=0.022).

Conclusion:
FOLFOX-based hepatic arterial infusion chemotherapy plus TKI and PD-1 inhibitors significantly improve survival prognosis compared with TKI plus PD-1 inhibitors. This is a potential first-line treatment for high-risk aHCC, with a relatively controlled safety profile.
Using a Reconstructive Ladder for Surgical Reconstruction of Transplant Ureteral Stricture Disease
Authors: Ji Emily , Rosenfeld Jonathan , Boehm Devin , Arteaga Rebecca , Raikar Aidan , Kim Jaewoo , Lee Ziho 
Published: July 2024

Objective:
Reconstruction of transplant ureteral stricture disease (USD) is a challenging surgical problem. In this article, we review our reconstructive ladder for robotic reconstruction of transplant USD and report our outcomes.

Materials and Methods:
We performed a retrospective review of patients undergoing robotic transplant reimplantation for USD after kidney transplantation at our institution between 11/2021 and 3/2023. Only patients with at least 1-year follow-up were included. The first rung of our reconstructive ladder is a side-to-side nontransecting reimplant. We prefer this method whenever possible because it avoids transection of the ureter, preserving the fragile blood supply. When this technique is not possible, because of long stricture length and/or limited bladder mobility, we proceed to the second rung of our reconstructive ladder, a Boari flap reconstruction. Surgical success in our cohort was defined as being hardware-free without evidence of ureteral obstruction on imaging.

Results:
There were 6 patients in our cohort: 3 underwent side-to-side reconstruction and 3 underwent Boari flap reconstruction. Median console time was 139 minutes (interquartile range [IQR] 85-175), estimated blood loss was 25 milliliters (IQR 25-81), and length of stay was 1 day (IQR 1-3). We had one major (Clavien ≥ III) complication, which was an intensive care unit transfer postoperatively for hypertension requiring a nicardipine drip. Median follow-up was 14 months (IQR 13-18) with a 100% surgical success rate.

Conclusion:
Utilization of a reconstructive ladder for management of transplant USD may allow for a systematic approach based on reconstructive principles. Our approach was associated with excellent intermediate-term outcomes.
Synchronous Insertion of Hyaluronic Acid-Based Biodegradable Rectal Spacer for Primary Prostate Cryotherapy
Authors: Parr Nigel J. , Dudderidge Timothy 
Published: July 2024

Purpose:
Recently, biodegradable spacers have been introduced to reduce rectal wall toxicity during external beam radiotherapy for prostate cancer. Rectal wall damage with fistula formation is a major complication of primary and salvage prostate cryotherapy. In theory, biodegradable spacers can be used to protect the rectum from the damage associated with cryotherapy. We describe a case of rectal spacer insertion for primary cryotherapy in a patient with high-risk localized prostate cancer who was unsuitable for other radical treatments because of previous treatment of rectal cancer, detailing the rationale for spacer selection, technique, and outcomes.

Materials and Methods:
A 57-year-old man was referred, following a regional specialist multidisciplinary team discussion, for an opinion regarding possible primary prostate cryotherapy. He had a history of anterior resection with chemoradiotherapy, followed by local relapse treated with total colectomy with ileoanal pouch formation and suffering from major postoperative complications. After further assessment and because of concern regarding damage to the efferent pouch limb during freezing, the possibility of spacer insertion between the ileoanal segment was considered and discussed. A hyaluronic acid gel spacer was selected and offered “off licence” on a compassionate basis. The spacer was introduced immediately before cryotherapy.

Results:
Recovery was uncomplicated apart from transient intermittent perineal pain, with good early functional and oncological outcomes.

Conclusions:
This is the first report of synchronous insertion of a hyaluronic acid gel spacer in prostate cryotherapy. We believe that the technique merits further investigation, with the potential to reduce complications and enhance freezing of the posterior aspect of the gland during cryotherapy.
Covered Versus Uncovered Metal Stents for the Drainage of the Malignant Distal Biliary Obstruction With ERCP
Authors: Guzmán-Calderón Gerly Edson , Chirinos Juan , Díaz-Arocutipa Carlos , Vesco Eduardo , Huerta-Mercado Jorge , Cedrón Hugo , Montezuma Dora , Poppele Gunther , Aparicio José Ramón 
Published: July 2024

Introduction and Aim:
Unresectable malignant distal biliary obstruction is a condition that should be treated with drainage and clearance of the biliary duct. self-expanded metal stents (SEMS) are known to be better and more effective than plastic stents because the patency is longer. The actual evidence is insufficient to recommend if it is better the use of SEMSu over SEMSc or vice versa for the drainage of the malignant distal biliary obstruction during ERCP. We performed a systematic review and meta-analyses to demonstrate if exists superiority between one or other type of SEMS performed by ERCP.

Materials and Methods:
We conducted a systematic review in different databases, such as PubMed, Cochrane, Medline, and OVID database. A search was made of all studies published up to May 2023.

Results:
Seven studies were analyzed. A total of 1070 patients were included. Of the total of patients, 48.9% were male. The cumulative stent patency, the failure rate, the survival probably and the adverse events rate, were similar between SEMSc and SEMSu groups. The stent migration rate was higher in the SEMSc group (RR=2.34 [95% CI: 1.35-4.08]). The tumor overgrowth was higher in the SEMSc group (RR=2.05 [95% CI: 1.13-3.72]). The tumor ingrowth was higher in the SEMSu group (RR=0.25 [95% CI: 0.11-0.61]).

Conclusions:
The conclusions of our study show that there are no differences between the use of uncovered SEMS and covered SEMS for palliative treatment of distal biliopancreatic obstructions, and it has no impact on mortality or patient survival. New functional studies regarding the type of stent cover, radial force or length thereof are required.
Colonoscopic removal of an intrauterine device with rectal perforation: A case report
Authors: Ye Lingrun , Zhu Yuanyuan , Zhu Fanglai 
Published: July 2024

Rationale:
The intrauterine device is one of the effective, safe, convenient, economical, and reversible contraceptive methods. Although its contraceptive effect is definite, some female patients may experience complications such as expulsion, bleeding, and pregnancy with the device in place. Rectal perforation is one of the rare and serious complications, which can lead to complications such as abdominal infection and intestinal adhesions, severely affecting the quality of life of patients.

Patient concerns:
A 34-year-old female was sent to the Department of Gastroenterology with noticeable left lower quadrant abdominal pain. She had presented with abdominal discomfort and anal tenesmus 1 year earlier. Two months ago, her abdominal pain had gradually worsened and she was presented to our hospital.

Diagnoses:
Investigations, including colonoscopy and computed tomography scan, had revealed an intrauterine device migrated and perforated into the rectum.

Interventions and outcomes:
The patient underwent successful colonoscopic removal of the intrauterine device. She recovered well after the treatment.

Lessons:
This case proves that endoscopic therapy can be considered the preferred method for removing intrauterine devices displaced into the digestive tract lumen.
Research on acupuncture and glial cells: A bibliometric analysis
Authors: Liu Qiong , Ai Kun , Jiang Xin-Ru , Yang Jing-Jing , Chen Lin , Cao Si-Hui , He Hao-Long , Liu Xia , Liu Mi 
Published: July 2024

Background:
There are a growing number of studies on the effect of acupuncture on glial cells in the central nervous system; however, there are few related bibliometric analyses in this area. Therefore, the purpose of this bibliometric study was to visualize the literature on acupuncture-regulated glial cells.

Methods:
On November 23, 2022, regular and review articles on acupuncture and glial cell-related research were retrieved from the Web of Science Core Collection database. The R package “bibliometrix” was used to summarize the main findings, count the occurrences of the top keywords, visualize the international collaboration network, and generate a 3-field plot. The VOSviewer software was used to conduct both co-authorship and co-occurrence analyses. CiteSpace was used to identify the best references and keywords with the highest citation rates.

Results:
Overall, 348 publications on acupuncture and glial cells were included. The publications were primarily from China, Korea, and the United States of America. The majority of publications were found in relevant journals. Apart from “acupuncture” and “glial cells,” the most frequently used keywords were “neuroinflammation,” “hyperalgesia,” and “pain.”

Conclusion:
This bibliometric study mapped a fundamental knowledge structure comprising countries, institutions, authors, journals, and articles in the research fields of acupuncture and glial cells over the last 3 decades. These results provide a comprehensive perspective on the wider landscape of this research area.
Publication practices of medical students at medical schools in Palestine: experiences, attitudes, and barriers to publishing
Authors: Jobran Afnan W.M. , AlSamhori Jehad Feras , Atyani Moath Rushdi , Abdulrazzak Mohammed , Islam Zarmina , Safdar Sifwa , Ahmad Shoaib , Ali Hassam 
Published: July 2024

Introduction and importance:
The progression in research and studies made by each nation’s scientific communities serves as one of the primary metrics for evaluating that nation’s scientific development; in this study of medical students at Palestinian medical colleges, attention was given to individuals who had been involved in research activities during their undergraduate training.

Materials and methods:
The authors conducted an online survey among medical students in Palestinian medical institutions, focusing on those engaged in research processes throughout their undergraduate studies. The study started in March 2022 and ended in the final week of May 2022. Participants were instructed to respond to statements regarding research work in the online self-administered questionnaire.

Results:
In the authors’ study, out of 425 participants, only 4.9% published an article. There were no significant gender disparities between males and females who published at least one article. There was a strong association between the year of study and publishing, with clinical students being more likely to publish (90.4%) than preclinical students (8.6%). The authors’ study revealed that students published either to enhance their curriculum vitae (33.0%) or out of personal interest (19.0%).

Conclusion:
While participants in the authors’ study demonstrate high levels of awareness and favorable attitudes toward research, active participation in the research community is still insufficient. More opportunity and mentorship are among the stated obstacles to participation in research. To overcome these obstacles, the authors suggest making long-term investments in research training, starting research clubs, and offering coaching and mentorship.