bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi‐Dentate Phosphine Ligand Derived from Cyclotetrasiloxane and Its Application in Palladium‐Catalyzed Alkoxycarbonylation of Alkenes
Authors: Liu Mengli , Xue Fei , Xu Chuanzhi , Wang Fang , Zeng Bo , Li Zhen , Xia Chungu 
Published: July 2024

AbstractThe development of phosphine ligands continues to be essential for palladium‐catalyzed homogeneous carbonylation reactions, particularly in achieving high regioselectivity. In this study, a cyclosiloxane‐based multi‐dentate phosphine ligand, L1 (V4‐4Ph2P), characterized by its high thermal stability and oxidation resistance, was synthesized through the radical addition of secondary phosphines to the double bonds of tetravinyltetramethylcyclotetrasiloxane. L1 was then used in the Pd‐catalyzed alkoxycarbonylation of a variety of olefins, including terminal and internal alkenes, cyclic alkenes, aromatic terminal alkenes as well as tetra‐, tri‐ and 1,1‐disubstituted alkenes to afford the desired esters with moderate to good yields. As elucidated via DFT calculations and in situ IR spectroscopy, the optimum spatial chelation modes and high stability of Pd−H active species were responsible for the enhancement of catalytic efficiency.
Radical 6‐Endo Addition Enables Pyridine Synthesis under Metal‐Free Conditions
Authors: Dong Xiaojuan , Shao Yingbo , Liu Zhengyi , Huang Xia , Xue Xiao‐Song , Chen Yiyun 
Published: July 2024

AbstractMetal‐free synthesis of heterocycles is highly sought after in the pharmaceutical industry and has garnered widespread attention due to eliminating the need to remove trace metal catalysts from the reaction. We report a radical 6‐endo addition method for pyridine synthesis from cyclopropylamides and alkynes under metal‐free conditions. Various terminal and substituted alkynes are inserted as C2 units into cyclopropylamides to synthesize versatile pyridines with 57 examples. Mechanistic investigations and computational studies indicate the unprecedented 6‐endo‐trig addition of vinyl radicals to the imine nitrogen atom rather than the conventional 5‐exo‐trig addition to the imine carbon atom, in which the hypervalent iodine(III) plays a critical role. This reaction easily scales up with excellent functional group compatibility and suits the late‐stage pyridine installation on complex molecules.
A new bio‐active Schiff base ligand and its Ni(II), Cu(II), Ag(I), Zn(II), Cd(II), and La(III) binuclear complexes: synthesis, DFT analysis, antimicrobial, DNA interaction, COXII inhibition, and molecular docking studies
Authors: Abdel‐Rahman Laila H. , Alzarzah Saleh F. , Abdel‐Hameed Mohamed , Shehata Mohamed R. , El‐Saghier Ahmed 
Published: July 2024

In the present work, 2‐hydroxy‐1‐naphthaldhyde and 2‐hydrazino‐N‐phenyl‐2‐thioxo‐acetamide are combined to create a new Schiff base. The novel ligand and its six new binuclear complexes with Ni(II), Cu(II), Ag(I), Zn(II), Cd(II), and La(III) are characterized via spectroscopic and analytical techniques, such as ultraviolet‐visible (UV–vis), infrared (IR), 1H NMR, 13C NMR, mass spectra, powder X‐ray diffraction (XRD), and thermogravimetric (TG) analysis. The spectral analysis indicated that the novel Schiff base may coordinate with the two metal ions. Additionally, the results indicated a square planar geometry for NiL, CuL, and AgL complexes and an octahedral geometry for ZnL, CdL, and LaL complexes. In contrast to the Schiff base ligand, different complex crystallinities were displayed in the powder XRD patterns. Significant thermodynamic parameter values were computed using the Coats–Redfern method which revealed high thermal stabilities of the complexes in the TG analysis. In vitro antibacterial, DNA‐binding, and anti‐inflammatory techniques were used for the biological evaluation. Moreover, to visualize the anti‐inflammatory action of complexes employing the cyclooxygenase enzyme receptor (PDB ID: 6COX), in silico docking was used. The serial dilution method evaluated the new compounds' in vitro antibacterial efficacy against three bacterial and one fungal strain. The results showed that the novel complexes showed remarkable efficiency against the bacterial growth of gram (+ve) Staphylococcus aureus compared to the parent ligand and the control. On the other hand, the ZnL, CdL, and AgL complexes showed excellent bactericidal activity. The inhibition of protein denaturation followed the following sequence: Ibuprofen > ZnL ˃ NiL ˃ AgL ˃ CuL > CdL > LaL > H2L. UV–visible and gel electrophoresis methods were used to examine the metal complexes and their ligand's affinity for binding DNA. An intercalative binding mechanism was suggested by the findings.
The olfactory system of sharks and rays in numbers
Authors: Aicardi S. , Bozzo M. , Guallart J. , Garibaldi F. , Lanteri L. , Terzibasi E. , Bagnoli S. , Dionigi F. , Steffensen J. F. , Poulsen A. B. , Domenici P. , Candiani S. , Amaroli A. , Němec P. , Ferrando S. 
Published: July 2024

AbstractCartilaginous fishes have large and elaborate olfactory organs, but only a small repertoire of olfactory receptor genes. Here, we quantitatively analyze the olfactory system of 21 species of sharks and rays, assessing many features of the olfactory organ (OOR) (number of primary lamellae, branches of the secondary folds, sensory surface area, and density and number of sensory neurons) and the olfactory bulb (OB) (number of neurons and non‐neuronal cells), and estimate the ratio between the number of neurons in the two structures. We show that the number of lamellae in the OOR does not correlate with the sensory surface area, while the complexity of the lamellar shape does. The total number of olfactory receptor neurons ranges from 30.5 million to 4.3 billion and the total number of OB neurons from 1.5 to 90 million. The number of neurons in the olfactory epithelium is 16 to 158 times higher (median ratio is 46) than the number of neurons in the OB. These ratios considerably exceed those reported in mammals. High convergence from receptor neurons to neurons processing olfactory information, together with the remarkably small olfactory receptor repertoire, strongly suggests that the olfactory system of sharks and rays is well adapted to detect a limited number of odorants with high sensitivity.
New labdane diterpenoids from Alpinia galanga: A new type of GLP‐1 secretagogues targeting the PKA‐CREB and PI3K‐Akt signaling axes
Authors: Liu Pei , Gongpan Pianchou , Wu Sheng‐Li , Li Xin‐Yu , Huang Xiao‐Yan , Ma Yun‐Bao , Geng Chang‐An 
Published: July 2024

AbstractGlucagon‐like peptide‐1 (GLP‐1) secretagogues are fascinating pharmacotherapies to overcome the defects of GLP‐1 analogs and dipeptidyl peptidase‐4 (DPP‐4) inhibitors in treating diabetes and obesity. To discover new GLP‐1 secretagogues from natural sources, alpigalangols A‐Q (1–17), 17 new labdane diterpenoids including four unusual nor‐labdane and N‐containing ones, were isolated from the fruits of Alpinia galanga. Most of the isolates showed GLP‐1 promotive effects in NCl‐H716 cells, of which compounds 3, 4, 12, and 14–17 were revealed with high promoting rates of 246.0%–413.8% at 50 µM. A mechanistic study manifested that the most effective compound 12 upregulated the mRNA expression of Gcg and Pcsk1, and the protein phosphorylation of PKA, CREB, and GSK3β, but was inactive on GPBAR and GPR119 receptors. Network pharmacology analysis indicated that the PI3K‐Akt pathway was involved in the GLP‐1 stimulation of 12, which was highly associated with AKT1, CASP3, PPARG, and ICAM1 proteins. This study suggests that A. galanga is rich in diverse labdane diterpenoids with GLP‐1 promoting effects, representing a new type of antidiabetic candidates from natural sources.
A propensity score‐matched comparison of neoadjuvant chemoradiotherapy with cisplatin‐5FU and carboplatin–paclitaxel in locally advanced esophageal squamous cell carcinoma: A Turkish oncology group study
Authors: Gürler Fatih , Tay Fatih , Sucuoğlu İşleyen Zehra , Yerlikaya Tahir , Hendem Engin , Esen Selin Aktürk , Sütçüoğlu Osman , Işık Deniz , Niğdelioğlu Büşra , Özen Miraç , Şahin Elif , Şakalar Teoman , Şengül Samancı Nilay , Alan Özkan , Hacıbekiroğlu İlhan , Algın Efnan , Yılmaz Melek Karakurt , Türk Hacı Mehmet , Öksüzoğlu Berna , Yavuz Aydın , Yüksel Osman , Bora Hüseyin , Yazıcı Ozan , Özet Ahmet , Özdemir Nuriye 
Published: July 2024

AbstractBackgroundNeoadjuvant treatment is the standard treatment in locally advanced ESCC. However, the optimal chemotherapy regimen is not known.MethodThis is a retrospective observational cohort study conducted with propensity score matching. Patients with resectable ESCC from 13 tertiary centers from Türkiye were screened between January 2011 and December 2021. We compared the efficacy and safety of neoadjuvant chemoradiotherapy with the CF and the CROSS regimens in patients with ESCC.ResultsThree hundred and sixty‐two patients were screened. Patients who received induction chemotherapy (n = 72) and CROSS‐ineligible (n = 31) were excluded. Two hundred and fifty nine patients received neoadjuvant chemoradiotherapy. After propensity score matching (n = 97 in both groups), the mPFS was 18.4 months (95% CI, 9.3–27.4) and 25.7 months (95% CI, 15.6–35.7; p = 0.974), and the mOS was 35.2 months (95% CI, 18.9–51.5) and 39.6 months (95% CI 20.1–59.2; p = 0.534), in the CF and the CROSS groups, respectively. There was no difference between subgroups regarding PFS and OS. Compared with the CF group, the CROSS group had a higher incidence of neutropenia (34.0% vs. 62.9%, p < 0.001) and anemia (54.6% vs. 75.3%, p = 0.003) in all grades. On the other hand, there was no significant difference in grade 3–4 anemia, grade 3–4 neutropenia, and febrile neutropenia between groups. There were more dose reductions and dose delays in the CROSS group than in the CF group (11.3% vs. 3.1%, p = 0.026 and 34.0% vs. 17.5%, p = 0.009, respectively). The resection rate was 52.6% in the CF‐RT and 35.1% in the CROSS groups (p = 0.014).ConclusionFavorable PFS and pCR rates and a comparable OS were obtained with the CROSS regimen over the CF regimen as neoadjuvant chemoradiotherapy in patients with ESCC.
Examining the role of pre‐visit anxiety on patient uncertainty and breast cancer patient–provider communication
Authors: Broadbridge Elizabeth A. , Venetis Maria K. 
Published: July 2024

AbstractObjectiveEffective communication between cancer patients and providers is critical for addressing psychological distress, reducing uncertainty, and promoting patient well‐being. This is particularly relevant during medical appointments that may elicit uncertainty, such as surgical consultations for newly diagnosed women with breast cancer. This study aimed to evaluate how pre‐appointment anxiety and illness uncertainty affect patient–provider communication in breast cancer surgical consultations and subsequent post‐appointment well‐being. Breast cancer patient anxiety has been studied as an outcome of provider communication, though less is known about the extent to which preexisting anxiety or uncertainty act as antecedents to effective patient–provider communication.MethodsThis study analyzed videorecorded breast cancer surgical consultations (N = 51) and corresponding patient surveys to understand how pre‐appointment anxiety influences pre‐appointment patient uncertainty, patient–provider communication during the appointment, and subsequent post‐appointment uncertainty.ResultsThe proposed model achieved good fit to the data such that more pre‐appointment anxiety was associated with more pre‐appointment uncertainty, more pre‐appointment anxiety was associated with more empathic opportunities per minute, and more empathic opportunities were associated with less post‐appointment uncertainty.ConclusionsResults indicate breast cancer patients with anxiety pre‐appointment are at‐risk for more illness uncertainty and are more likely to explicitly provide empathic opportunities. This supports the need for added attention to empathic opportunities to not only address patients emotionally but to also assess whether a patient may be at higher risk of having preexisting anxiety.
Real life clinical outcomes of relapsed/refractory diffuse large B cell lymphoma in the rituximab era: The STRIDER study
Authors: Dogliotti Irene , Peri Veronica , Clerico Michele , Vassallo Francesco , Musto Davide , Mercadante Silvio , Ragaini Simone , Botto Barbara , Levis Mario , Novo Mattia , Ghislieri Marco , Molinaro Luca , Mortara Umberto , Consoli Chiara , Lonardo Alessio , Bondielli Giulia , Ferrero Simone , Freilone Roberto , Ricardi Umberto , Bruno Benedetto , Cavallo Federica 
Published: July 2024

AbstractBackgroundRelapse and refractory (R/R) rates after first‐line R‐CHOP in diffuse large B cell lymphomas (DLBCL) are ~40% and ~15% respectively.AimsWe conducted a retrospective real‐world analysis aimed at evaluating clinical outcomes of R/R DLBCL patients.Material and MethodsOverall, 403 consecutive DLBCL patients treated in two large hematological centers in Torino, Italy were reviewed.ResultsAt a median follow up of 50 months, 5‐year overall survival from diagnosis (OS‐1) was 66.5%, and 2‐year progression free survival (PFS‐1) was 68%. 134 (34.4%) patients relapsed (n = 46, 11.8%) or were refractory (n = 88, 22.6%) to R‐CHOP. Most employed salvage treatments included platinum salt‐based regimens in 38/134 (28.4%), lenalidomide in 14 (10.4%). Median OS and PFS after disease relapse or progression (OS‐2 and PFS‐2) were 6.7 and 5.1 months respectively. No significant difference in overall response rate, OS‐2 or PFS‐2 in patients treated with platinum‐based regimens versus other regimens was observed. By multivariate analysis, age between 60 and 80 years, germinal center B cell type cell of origin and extranodal involvement of <2 sites were associated with better OS‐2.DiscussionOur findings confirm very poor outcomes of R/R DLBCL in the rituximab era. Widespread approval by national Medicine Agencies of novel treatments such as CAR‐T cells and bispecific antibodies as second‐line is eagerly awaited to improve these outcomes.
Adjuvant 5‐fluorouracil and portal vein infusion chemotherapy followed by gemcitabine for pancreatic cancer
Authors: Kitago Minoru , Endo Yutaka , Aiura Koichi , Takigawa Yutaka , Tani Noriyuki , Matsui Junichi , Suzuki Keiichi , Nishiyama Ryo , Nakano Yutaka , Abe Yuta , Yagi Hiroshi , Shinoda Masahiro , Itano Osamu , Tanabe Minoru , Kitagawa Yuko 
Published: July 2024

AbstractBackgroundAlthough adjuvant gemcitabine (GEM) monotherapy improves the overall survival (OS) of patients with resected pancreatic cancer, its efficacy requires further improvement. This multicenter, phase II study investigated the efficacy of adjuvant portal vein infusion (PVI) chemotherapy followed by GEM therapy in patients with resected pancreatic cancer.Methods5‐fluorouracil (250 mg/day) and heparin (2000 IU/day) PVI chemotherapy were combined with systemic administration of mitomycin C (4 mg; days 6, 13, 20, and 27) and cisplatin (10 mg; days 7, 14, 21, and 28) for 4 weeks (PI4W), followed by GEM (1000 mg/m2; days 1, 8, and 15 every 4 weeks for 6 months). The primary endpoint was relapse‐free survival (RFS) and the secondary endpoints were OS and treatment completion.ResultsBetween November 2010 and August 2013, 53 patients who underwent complete resection were enrolled, including 30, 20, and 3 patients who underwent pancreaticoduodenectomies and distal and total pancreatectomies, respectively. In total, 51 (96.2%) patients underwent R0 resection, of whom 3, 2, 12, 35, 0, and 1 had stages IA, IB, IIA, IIB, III, and IV cancer, respectively, and 47 (88.7%) patients completed PI4W. The median RFS was 22.0 months (1‐, 3‐, 5, and 10 years RFS: 64.9%, 38.1%, 38.1%, and 38.1%, respectively), whereas the median OS was 32.0 months (1‐, 3‐, 5, and 10 years OS:86.6%, 47.2%, 44.4%, and 44.4%, respectively).ConclusionTreatment with PI4W followed by GEM for 6 months after surgery may be beneficial in patients undergoing curative resection of pancreatic cancer.
The power of connection: Resource and responsibility in the virtual community experience of Italian trans and gender‐diverse activists
Authors: Compare Christian , Lorusso Maric Martin , Albanesi Cinzia 
Published: July 2024

AbstractThe community concept underwent a series of adaptations and integrations throughout the decades. One of these transitions was supported by the rise of virtual communities, especially social network sites (SNSs). These platforms are recognized to serve as spaces for marginalized groups like transgender and gender diverse (TGD) individuals to create safe and inclusive communities for self‐expression and activism. To investigate how TGD activists engage with SNS, 21 activists were interviewed, exploring challenges, potentials and perceptions. Reflexive thematic analysis revealed that participants perceive SNS in line with the community experience framework, viewing them as resources for accessing information, providing support and fostering belonging and investment, and as acts of responsibility aimed at nurturing reciprocity, sense of duty and social justice advocacy. However, SNS also proved to expose activists to vulnerability within the TGD community itself, where a hierarchy that marginalizes TGD identities with transnormative experiences is often reproduced. Additionally, SNS anonymity offers a safer environment for TGD individuals to come out but protects hate speech perpetrators. Thus, while pivotal in TGD activism and community building, the dual nature of SNS underscores the complexities of virtual spaces. Finally, the study calls for redefining the concept of community beyond the virtual–physical dichotomy.
Chemical Diversity of Aspergillus alliaceus Phenotypes: Discovery of brominated bianthrones with activity against triple‐negative breast cancer cell lines
Authors: Mandelare Paige E. , Yee Samantha S. , Icenhour Daniel G. , Kaweesa Elizabeth N. , McCauley Mark , Risinger April L. , Rudolf Jeffrey D. , Loesgen Sandra 
Published: July 2024

Marine‐derived fungi have emerged as a source for novel metabolites with a broad range of bioactivities. However, accessing the full potential of fungi under standard laboratory conditions remains challenging. LC‐MS‐based metabolomics in combination with varied culture conditions is a fast and powerful tool to detect new metabolites. Here, three developmental forms of the marine‐derived fungus Aspergillus alliaceus were analyzed and 14 fungal metabolites, including new brominated polyketides (11‐14) were isolated. Structure elucidation relied mainly on 1D and 2D NMR techniques and was supported by low‐ and high‐resolution mass spectrometry and DFT‐based computations. We sequenced the A. alliaceus genome, identified the bianthrone‐producing biosynthetic gene cluster, and conducted expression analysis on genes involved in sexual development and biosynthesis. The NCI‐60 cell line panel revealed selective in vitro activity against triple‐negative breast cancer (TNBC) for the halogenated allianthrones and their full anti‐proliferative and cytotoxic effects were evaluated in five TNBC cell lines.
The influence of color vision deficiency on vessel visibility during colorectal endoscopic submucosal dissection and the potential advantage of red dichromatic imaging to achieve color vision barrier‐free
Authors: Ohno Akiko , Miyamoto Naohiko , Kaji Ryosuke , Shirakawa Takahiro , Watanabe Moegi , Sumi Ryutaro , Jinbo Yoko , Kusuhara Mitsunori , Miyoshi Jun , Hisamatsu Tadakazu 
Published: July 2024

AbstractObjectivesAlthough color information is important in gastrointestinal endoscopy, there are limited studies on how endoscopic images are viewed by people with color vision deficiency. We aimed to investigate the differences in the visibility of blood vessels during endoscopic submucosal dissection (ESD) among people with different color vision characteristics and to examine the effect of red dichromatic imaging (RDI) on blood vessel visibility.MethodsSeventy‐seven pairs of endoscopic images of white light imaging (WLI) and RDI of the same site were obtained during colorectal ESD. The original images were set as type C (WLI‐C and RDI‐C), a common color vision. These images were computationally converted to simulate images perceived by people with color vision deficiency protanope (Type P) or deutanope (Type D) and denoted as WLI‐P and RDI‐P or WLI‐D and RDI‐D. Blood vessels and background submucosa that needed to be identified during ESD were selected in each image, and the color differences between these two objects were measured using the color difference (ΔE00) to assess the visibility of blood vessels.ResultsΔE00 between a blood vessel and the submucosa was greater under RDI (RDI‐C/P/D: 24.05 ± 0.64/22.85 ± 0.66/22.61 ± 0.64) than under WLI (WLI‐C/P/D: 22.26 ± 0.60/5.19 ± 0.30/8.62 ± 0.42), regardless of color vision characteristics. This improvement was more pronounced in Type P and Type D and approached Type C in RDI.ConclusionsColor vision characteristics affect the visibility of blood vessels during ESD, and RDI improves blood vessel visibility regardless of color vision characteristics.
Global climate change‐driven impacts on the Asian distribution of Limassolla leafhoppers, with implications for biological and environmental conservation
Authors: Ran Weiwei , Chen Jiajia , Zhao Yuanqi , Zhang Ni , Luo Guimei , Zhao Zhibing , Song Yuehua 
Published: July 2024

AbstractKnowing the impacts of global climate change on the habitat suitability distribution of Limassolla leafhoppers contributes to understanding the feedback of organisms on climate change from a macroecological perspective, and provides important scientific basis for protecting the ecological environment and biodiversity. However, there is limited knowledge on this aspect. Thus, our study aimed to address this gap by analyzing Asian habitat suitability and centroid shifts of Limassolla based on 19 bioclimatic variables and occurrence records. Selecting five ecological niche models with the outstanding predictive performance (Maxlike, generalized linear model, generalized additive model, random forest, and maximum entropy) along with their ensemble model from 12 models, the current habitat suitability of Limassolla and its future habitat suitability under two Shared Socio‐economic Pathways (SSP1‐2.6 and SSP5‐8.5) in the 2050s and 2090s were predicted. The results showed that the prediction results of the five models are generally consistent. Based on ensemble model, 11 potential biodiversity hotspots with high suitability were identified. With climate change, the suitable range of Limassolla will experience both expansion and contraction. In SSP5‐8.52050s, the expansion area is 118.56 × 104 km2, while the contraction area is 25.40 × 104 km2; in SSP1‐2.62090s, the expansion area is 91.71 × 104 km2, and the contraction area is 26.54 × 104 km2. Furthermore, the distribution core of Limassolla will shift toward higher latitudes in the northeast direction, and the precipitation of warmest quarter was found to have the greatest impact on the distribution of Limassolla. Our research results supported our four hypotheses. Finally, this research suggests establishing ecological reserves in identified contraction to prevent habitat loss, enhancing the protection of biodiversity hotspots, and pursuing a sustainable development path with reduced emissions.
Langerhans cells and skin immune diseases
Authors: Zhu Ronghui , Yao Xu , Li Wei 
Published: July 2024

AbstractLangerhans cells (LCs) are the key antigen‐presenting cells in the epidermis in normal conditions and respond differentially to environmental and/or endogenous stimuli, exerting either proinflammatory or anti‐inflammatory effects. Current knowledge about LCs mainly originates from studies utilizing mouse models, whereas with the development of single‐cell techniques, there has been significant progress for human LCs, which has updated our understanding of the phenotype, ontogeny, differentiation regulation, and function of LCs. In this review, we delineated the progress of human LCs and summarized LCs’ function in inflammatory skin diseases, providing new ideas for precise regulation of LC function in the prevention and treatment of skin diseases.