bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reverse zoonosis of the 2022–2023 human seasonal H3N2 detected in swine
Authors: Zeller Michael A. , Carnevale de Almeida Moraes Daniel , Ciacci Zanella Giovana , Souza Carine K. , Anderson Tavis K. , Baker Amy L. , Gauger Phillip C. 
Published: August 2024

AbstractThe Iowa State University Veterinary Diagnostic Laboratory detected nineteen human-to-swine reverse zoonoses of the 2022–2023 human seasonal H3N2 between November 2022 and November 2023. Cases from seven U.S. locations were detected: 3 Colorado, 1 Illinois, 1 Indiana, 2 Missouri, 7 North Carolina, 1 Ohio, and 1 Pennsylvania. One additional case was detected in Mexico and two cases were identified from Chile. Case samples were comprised of 4 nasal swabs and 15 oral fluids. Virus was successfully isolated from two of four nasal swab samples, but isolation from oral fluids was unsuccessful. The swine detections of H3 human viruses were classified to one of two human-seasonal H3 clades, 3C.2a1b.2a.2b and 3C.2a1b.2a.2a.1. Phylogenetic inference indicated at minimum 7 reverse zoonotic events occurred, with possible swine-to-swine transmission following the initial spillover. Twelve neuraminidase genes were sequenced, and nine were classified as human-seasonal H3N2 lineage: the remaining were endemic swine IAV NA genes from the N2.2002B, N2.1998, or the N1.Classical lineage, suggesting reassortment. The two viral isolates obtained from nasal swab samples were sequenced and were entirely human-lineage viruses. Seven swine samples with human seasonal H3 were sequenced and revealed co-detections with H1 1A.3.3.3 (gamma), with internal gene segments from both the triple reassortant internal gene (TRIG) and pandemic 2009 lineages. Serologic investigation of samples from swine production systems provided evidence for infection with human seasonal H3N2. One farm in the United States and four farms in Mexico had concurrent virologic evidence. The swine-isolated 3C.2a1b.2a.2b H3N2 was antigenically distinct from endemic 1990.4.A, 2010.1, and 2010.2 swine H3N2 lineages, but retained antigenic similarity to a recent human seasonal H3N2 (A/Darwin/6/2021). Pigs experimentally inoculated with a representative isolate demonstrated replication in the nose and lungs and minimal to mild macroscopic and microscopic lung lesions, but primary pigs did not transmit the virus to indirect contacts. If sustained in the pig population, this human seasonal H3 would represent the first new lineage detected in pigs the 2020 decade and present an emerging threat to swine health and production.
The salivary metabolome of children and parental caregivers in a large-scale family environment study
Authors: Rothman Jason A. , Piccerillo Hillary L. , Dunham Sage J. B. , Riis Jenna L. , Granger Douglas A. , Thomas Elizabeth A. , Whiteson Katrine L. 
Published: August 2024

AbstractHuman metabolism is complex, and is impacted by genetics, cohabitation, diet, health, and environmental inputs. As such, we applied untargeted LC-MS metabolomics to 1425 saliva samples from a diverse group of elementary school-aged children and their caregivers collected during the Family Life Project, of which 1344 were paired into caregiver/child dyads. We compared metabolomes within and between homes, performed population-wide “metabotype” analyses, and measured associations between metabolites and salivary biomeasures of inflammation, antioxidant potential, environmental tobacco smoke (ETS) exposure, metabolic regulation, and heavy metals. Children and caregivers had similar salivary metabolomes, and dyad explained most metabolomic variation. Our data clustered into two groups, indicating that “metabotypes” exist across large populations. Lastly, several metabolites—putative oxidative damage-associated or pathological markers—were correlated with the above-mentioned salivary biomeasures and heavy metals. Implications of the family environment’s effects on metabolomic variation at population, dyadic, and individual levels for human health are discussed.
Performance of massive MIMO‐NOMA systems with low complexity group SIC receivers and low‐resolution ADCs
Authors: Zheng Changliang , Yang Kang , Fu Tielian , Liu Tianle , Yang Mengqi 
Published: August 2024

AbstractMassive multiple‐input multiple‐output and non‐orthogonal multiple access (MIMO‐NOMA) with low‐resolution analog‐to‐digital converters (ADCs) have been widely considered for the next‐generation wireless communication systems. However, the performance of the system including power‐scaling law has not been well investigated for the practical low complexity receivers. Employing the additive quantization noise model, we derive asymptotic approximate expressions of the spectrum efficiency for the system with group successive interference cancellation (GSIC) receivers over Rician fading channels. Based on these approximations, we conduct a unified asymptotic analysis for the system with linear, SIC, and GSIC receivers. The analysis reveals the transmission power can be scaled by the number of antennas for the system with GSIC receivers and shows the effects of crucial parameters including the number of groups, resolution bits, and antennas on the performance. Given a quality of service, the minimum data transmission power is also calculated for each user and the corresponding approximate power allocation is derived. The asymptotic analysis and the accuracy of the power allocation approximation are then verified by simulation results. Numerical results also demonstrate that high spectrum efficiency and energy efficiency can be achieved by the system with medium‐resolution ADCs and low complexity maximum ratio combining‐GSIC receivers with a small number of groups.
A compact half‐mode substrate integrated waveguide bandpass filter based on highly confined slow waves with loading capacitive patches
Authors: Wang Ning‐Ning , Zhang De‐Wei , Liu Qing , Qian Hang , Qu Wei‐Zhe 
Published: August 2024

AbstractA novel slow‐wave half‐mode substrate integrated waveguide (HMSIW) bandpass filter (BPF) is proposed based on spoof surface plasmon polaritons (SSPPs) with loading capacitive patches (LCPs). The bandpass characteristics are achieved by etching complementary SSPPs on the metal patches of the HMSIW. SSPPs exhibit a slow‐wave effect, which effectively reduces the overall size of the filter. At the same time, using proper LCPs between the HMSIW metal via and the complementary SSPPs structure, the effective dielectric constant of the HMSIW can be changed, reducing the low cutoff frequency and further facilitating the miniaturisation of size. A prototype of the proposed filter is designed, fabricated, and measured. The measured results show that the proposed filter has the in‐band insertion loss of 1 and 3 dB passband range of 6.4–9.8 GHz.
Universal domain adaptation for machinery fault diagnosis based on multi‐scale dual attention network and entropy‐based clustering
Authors: Lee Chun‐Yao , Zhuo Guang‐Lin 
Published: August 2024

AbstractRecently, data‐driven cross‐domain fault diagnosis methods for rotating machinery have been successfully developed. However, most existing diagnostic methods assume that the label spaces of the source and target domains are the same. In practice, the relationship between the label space of the source domain and the target domain is unknown, that is, the universal domain adaptation (UDA) problem. Existing overall domain distribution alignment methods are less effective in facing UDA problems. Thus, this article proposes a deep learning‐based UDA model. First, the proposed model combines multi‐scale learning and dual attention block, which can improve the capability to extract effective features. Then, an entropy optimization strategy is introduced to promote target domain sample clustering without prior knowledge. Finally, the effectiveness of the proposed model is verified on a public dataset of rotating machinery. The results show that the proposed method outperforms six existing cross‐domain fault diagnosis methods.
Coverage of lateral soft tissue defects with sartorius muscle flap after distal femoral replacement for malignant bone tumors
Authors: Minami Naoki , Tsukamoto Shinji , Shimizu Takamasa , Honoki Kanya , Hasegawa Hideo , Masunaga Tomoya , Kido Akira , Errani Costantino , Mavrogenis Andreas F. , Tanaka Yasuhito 
Published: August 2024

Introduction: To prevent infection after limb-sparing surgery for primary malignant bone tumors, it is important to cover the megaprosthesis with muscle tissue that has sufficient blood flow. Coverage with a lateral gastrocnemius flap has been reported in cases of distal femoral replacement in which the vastus lateralis and vastus intermedius muscles have been resected; however, the risk of peroneal nerve palsy is reportedly high because the muscle flap passes near the peroneal head. This study was performed to examine the postoperative outcomes of patients with primary malignant bone tumors of the distal femur who underwent wide resection (including the vastus lateralis and vastus intermedius muscles) followed by reconstruction with a megaprosthesis and coverage of the lateral side of the prosthesis with a sartorius muscle flap. Methods: We retrospectively analyzed three patients who underwent reconstruction with a megaprosthesis after wide resection of a primary malignant bone tumor of the distal femur involving the vastus lateralis and vastus intermedius muscles and reconstruction of the soft tissue defect on the lateral side of the prosthesis with a sartorius muscle flap. Results: The average defect size was 6 × 13 cm, the average time required for a sartorius muscle flap was 100 min, and the average implant coverage was 93%. The average postoperative follow-up period was 35 months, during which no postoperative complications such as infection, skin necrosis, or nerve palsy occurred. Discussion: The distally based sartorius muscle flap is easy to elevate in the supine position, has minimal functional loss after harvesting, and has minimal risk of nerve palsy. It can be advocated as the first option for coverage of soft tissue defects lateral to distal femoral replacement.
Prävention postoperativer Wundinfektionen nach Korrektur neuromuskulärer Skoliosen
Authors: Fischer Thies Martin , Kösters Justinus B. , Schneider Marc , Liljenqvist Ulf 
Published: August 2024

Zusammenfassung
Ziel der Studie Identifikation von Faktoren, welche postoperative Wundinfektionen bei operativ therapierten neuromuskulären Skoliosen (NMS) beeinflussen und wie diesen präventiv zu begegnen ist.
Material und Methoden Erhoben wurden Daten von 2016–2020 von Patienten mit einer dorsal einzeitig korrigierten NMS mit einem Mindestnachbetrachtungszeitraum von 12 Monaten. Ab Herbst 2018 erfolgte die Verwendung eines perioperativ applizierten epikutanen Vakuumverbands (EV) für 5 Tage. Die postoperative Infektionsrate und das verursachende Keimspektrum wurden analysiert.
Ergebnisse 83 Patienten (m : f 39 : 44) wurden eingeschlossen.
Gruppe 1 (ohne EV) umfasste 48 Patienten, Gruppe 2 (mit EV) 35. Das durchschnittliche Alter
bei OP betrug 16,6 ± 4,94 Jahre. 60 Patienten waren inkontinent, 58 nicht geh- und stehfähig.
Der präoperative Cobb-Winkel der Hauptkrümmung belief sich auf 87,7 ± 18,4°, die pelvic
obliquity auf 18,4 ± 12,25°. Die fusionierte Strecke umfasste 14,59 ± 1,65 Wirbelkörper, bei
einer durchschnittlichen OP-Dauer von 221 ± 49 min. Die OP-Dauer in Gruppe 2 war geringgradig
kürzer (229,92 vs. 216,93 min, p=0,1) ohne einen Unterschied bzgl. der fusionierten Strecke
(14,63 vs. 14,48 Wirbel, p=0,35). Patienten, bei denen eine Wundinfektion auftrat, hatten eine
nicht-signifikant längere Instrumentationsstrecke (15,16 Wirbel, p=0,1) und längere OP-Dauer
(246,2 min, p=0,19). Gruppe 1 wies 7 Infektionen auf (14,5%), davon 4 verursacht durch
Fäkal-Keime, 3 durch Hautkeime. In Gruppe 2 trat keine Infektion auf (p<0,05). Patienten
mit einer Infektion wurden 3-mal ± 1,2-mal revidiert. Die Dauer der postoperativ notwendigen
intensivmedizinischen Behandlung stieg bei Infektion von 80,6 ± 132,7 auf 457,6 ± 315,8 h
(p<0,05), der stationäre Aufenthalt verlängerte sich von 14,31 ± 5,65 d auf 34,3 ± 21,6 d
(p<0,05). Es wurde eine antiinfektive Therapie über 56,1 ± 28,58 d verabreicht (16,3 ± 8,7
d i.v., 39,8 ± 24,4 d p.o.).
Schlussfolgerung Die Verwendung eines epikuanten Vakuumverbandes für 5 Tage nach operativer Korrektur einer NMS reduziert die Rate von Wundinfektionen signifikant.
Lokaltherapie im Stadium IV bei Oligopersistenz oder Progression
Authors: Schulz Christian 
Published: August 2024

ZusammenfassungOligopersistenz und Oligoprogress stellen definierte Situationen des metastasierten Lungenkarzinoms dar. Oligopersistenz bedeutet das Verbleiben weniger Metastasen unter einer wirksamen Systemtherapie. Unter Oligoprogress versteht man eine weitgehend kontrollierte Tumorerkrankung mit einigen Metastasen, die einen erneuten Progress aufweisen. In der Situation Oligopersistenz soll durch ergänzende lokal ablative Maßnahmen aller verbliebenen Läsionen eine vollständige Tumorkontrolle mit Verbesserung der Prognose bis zur Heilung erzielt werden. In der Situation Oligoprogress zielen lokal ablative Maßnahmen darauf ab, erneut eine vollständige Kontrolle der Tumorerkrankung unter Fortführung der etablierten Systemtherapie herzustellen. Die Konzepte gehen auf Überlegungen zurück, die bereits vor mehr als 30 Jahren unter dem Begriff der Oligometastasierung von Hellman und Weichselbaum in der Onkologie eingeführt wurden. Insbesondere durch zielgerichtete Therapien des molekular
alterierten Lungenkarzinoms und Chemo-Immuntherapie-Regime mit hohen Ansprechraten und langer Ansprechdauer haben multimodale Therapiekonzepte in der Situation der Oligopersistenz und Oligoprogression an Bedeutung gewonnen. Es wird die verfügbare Evidenz dargelegt und durch Fallbeispiele aus dem eigenen Zentrum ergänzt.
A Case of Vein of Galen Aneurysmal Malformation Diagnosed Prenatally in a Monochorionic-Diamniotic Twin Pregnancy
Authors: Berger Dana Senderoff , Robinson Andre , Chervenak Judith , Thomas Kristen , Srinivasan Ranjini , Sharma Geeta , Roman Ashley S. , Penfield Christina A. , Limaye Meghana 
Published: August 2024

AbstractWe present a case of a vein of Galen aneurysmal malformation (VGAM), a rare congenital arteriovenous malformation, in one fetus of a monochorionic-diamniotic twin pregnancy. The diagnosis was made with color Doppler ultrasonography at 28 weeks and the affected fetus was found to have worsening cardiomegaly on subsequent fetal echocardiograms. She was emergently delivered at 32 weeks for abnormal fetal heart rate tracing of the affected twin. Magnetic resonance imaging of the brain findings after delivery demonstrated severe neurological injury; therefore, postnatal embolization was not performed. The neonate died on day of life 9. The cotwin survived without neurological complications. This is the first case in the literature of a VGAM diagnosed prenatally in a monochorionic-diamniotic twin pregnancy and demonstrates the challenge of delivery timing with prenatal diagnosis in a twin pregnancy.
Harnessing Risk Assessment for Thrombosis and Bleeding to Optimize Anticoagulation Strategy in Nonvalvular Atrial Fibrillation
Authors: Zhao Yue , Cao Li-Ya , Zhao Ying-Xin , Zhao Di , Huang Yi-Fan , Wang Fei , Wang Qian 
Published: August 2024

Background Oral anticoagulation (OAC) following catheter ablation (CA) of nonvalvular atrial fibrillation (NVAF) is essential for the prevention of thrombosis events. Inappropriate application of OACs does not benefit stroke prevention but may be associated with a higher risk of bleeding. Therefore, this study aims to develop clinical data-driven machine learning (ML) methods to predict the risk of thrombosis and bleeding to establish more precise anticoagulation strategies for patients with NVAF.
Methods Patients with NVAF who underwent CA therapy were enrolled from Southwest Hospital from 2015 to 2023. This study compared eight ML algorithms to evaluate the predictive power for both thrombosis and bleeding. Model interpretations were recognized by feature importance and SHapley Additive exPlanations methods. With potential essential risk factors, simplified ML models were proposed to improve the feasibility of the tool.
Results A total of 1,055 participants were recruited, including 105 patients with thrombosis and 252 patients with bleeding. The models based on XGBoost achieved the best performance with accuracies of 0.740 and 0.781 for thrombosis and bleeding, respectively. Age, BNP, and the duration of heparin are closely related to the high risk of thrombosis, whereas the anticoagulation strategy, BNP, and lipids play a crucial role in the occurrence of bleeding. The optimized models enrolling crucial risk factors, RF-T for thrombosis and Xw-B for bleeding, achieved the best recalls of 0.774 and 0.780, respectively.
Conclusion The optimized models will have a great application potential in predicting thrombosis and bleeding among patients with NVAF and will form the basis for future score scales.
The Predictive Value of hsa_circ_0001313 (circCCDC66) in Egyptian Rectal Cancer Patients: A New Era in Precision Medicine
Authors: Batea Hend M. , El-dine Safaa H. Mohy , Kamha Eman M. , Khedr Gehan M. , Moaz Ahmed , Abdelmonsif Doaa A. 
Published: August 2024

Abstract
Introduction The involvement of circular RNAs (circRNAs) in cancer research has been emphasized in recent years due to evidence of their involvement in malignancy pathogenesis. Yet, the involvement of circRNAs in the resistance to cancer treatment remains to be clarified. Circular RNA 0001313 (circ_0001313) has a distinct expression in different cancers, and it is overexpressed in rectal cancer; hence, it could be a promising non-invasive stable biomarker and a therapeutic target for rectal cancer. Yet, its predictive role has not been studied in Egyptian rectal cancer patients.
Objective To study the predictive value of circulating circ_0001313 (circ_CCDCC6) in assessing the response to neoadjuvant chemoradiotherapy (nCRT) in patients with rectal cancer and its relation to radiological and pathological response.
Materials and Methods The present study included 50 patients with locally advanced rectal cancer and 20 healthy subjects as controls. The analysis of the relative circ_CCDCC6 expression was performed using the real-time quantitative polymerase chain reaction (qPCR) method.
Results The circ_CCDCC6 was found to be significantly more expressed in rectal cancer patients compared with controls (p < 0.001). Moreover, its expression level was significantly higher in nonresponders to nCRT compared with responders (p < 0.001). Furthermore, a receiver operating characteristic (ROC) curve analysis was performed to evaluate the predictive performance of circulating circ_0001313; its sensitivity in predicting the response to treatment was of 93.33%, and its specificity was of 91.43%.
Conclusion Significant up-regulation of circ_0001313 in rectal cancer suggests a potential oncogenic role, and higher expression of circ_0001313 among nonresponders suggests that it could be a predictor of the response to nCRT.
The Approach to Altered Mental Status in the Intensive Care Unit
Authors: Albin Catherine S.W. , Cunha Cheston B. , Glaser Timlin P. , Schachter Micaela , Snow Jerry W. , Oto Brandon 
Published: August 2024

AbstractAltered mental status (AMS) is a syndrome posing substantial burden to patients in the intensive care unit (ICU) in both prevalence and intensity. Unfortunately, ICU patients are often diagnosed merely with syndromic labels, particularly the duo of toxic–metabolic encephalopathy (TME) and delirium. Before applying a nonspecific diagnostic label, every patient with AMS should be evaluated for specific, treatable diseases affecting the central nervous system. This review offers a structured approach to increase the probability of identifying specific causal etiologies of AMS in the critically ill. We provide tips for bedside assessment in the challenging ICU environment and review the role and yield of common neurodiagnostic procedures, including specialized bedside modalities of diagnostic utility in unstable patients. We briefly review two common etiologies of TME (uremic and septic encephalopathies), and then review a selection of high-yield toxicologic, neurologic, and infectious causes of AMS in the ICU, with an emphasis on those that require deliberate consideration as they elude routine screening. The final section lays out an approach to the various etiologies of AMS in the critically ill.
Robust electronic phase transition against cation disorder in high-entropy pyrochlore iridates
Authors: Contant D. , McNally G. M. , Krajewska A. , Takagi H. , Takayama T. 
Published: August 2024

High-entropy pyrochlore iridates A2Ir2O7 with multiple trivalent A cations were synthesized. The parent ternary A2Ir2O7 displays a variety of electronic phases depending on the size of A cations; Pr2Ir2O7 with a large A cation shows semimetallic behavior down to low temperatures, whereas A2Ir2O7 with smaller A cations, such as Nd2Ir2O7 and Eu2Ir2O7, displays a (semi)metal to magnetic insulator transition as a function of temperature. By further reducing the A cation size, smaller than Y3+, A2Ir2O7 becomes a Mott insulator, and long-range magnetic order takes place below room temperature. The metal–insulator transition and magnetic ordering turned out to be robust against strong disorder induced by the mixing of more than five A-cations in the high-entropy A2Ir2O7. The transition temperatures were found to scale with the average ionic radius of multiple A-cations. In contrast, high-entropy A2Ir2O7 including Bi3+ exhibits metallic behavior down to 2 K, which is likely associated with the presence of oxygen vacancies as in the parent Bi2Ir2O7. Although these indicate that the overall electronic structure of A2Ir2O7 remains intact in the presence of high-entropy configuration at the A-site, the transport properties suggest that fine details of the band structure may be modulated by local distortion. Strong disorder at the A-site of complex oxides may be exploited as a tool to control electronic properties.
Microaggressions and impoliteness at the crossroads
Authors: Guardamagna Caterina , Hampton Jessica , Roccia Mariana , Sredanovic Djordje 
Published: August 2024

Abstract
The Brexit process created a loss of rights and heightened hostility towards EU migrants within the UK, even
among groups previously shielded from such animosity, notably EU academics. This paper is based on 24 clear instances of
microaggressions, and two bordering hate speech involving EU academics in England and synthetises the psychology/philosophy
literature on microaggressions with linguistic frameworks of “rapport management” and “impoliteness triggers” leading to a novel
understanding of the phenomenon. Microaggressions are defined as a specific type of impoliteness “of the mild kind”, characterised
by repetition at the individual and/or the collective level, which produces feelings of annoyance, irritation and shock. This
study shows that Brexit-microaggressions usually involve social identity face and the breach of equity/association sociality rights.
They mostly take the shape of formulae echoing slogans entrenched in the discourses of Brexit and arise out of a mismatch between
pro-Brexit comments uttered in the presence of an EU migrant.
Turn continuation in yeah/no
responding turns
Authors: Szczepek Reed Beatrice , Cantarutti Marina 
Published: August 2024

Abstract
This study makes an original contribution to the understanding of sound patterns in interaction by
investigating glottalization and linking at word boundaries in naturally occurring talk. Specifically, the study shows how speakers of British English make use of the contrast between glottalized
and linked vowel-fronted TCU boundaries in multi-unit
turns. Second TCUs whose initial vowel is joined to the last sound of the first TCU routinely either extend or
elaborate on the social action of the first TCU. Second TCUs whose initial vowel is glottalized routinely accomplish
new actions that are distinct from those accomplished by the first TCU. After giving an overview of a wider collection
of cases, the analysis focuses on yeah/no responding turns.