bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Preparation of Triazoloindoles via Tandem Copper Catalysis and Their Utility as α‐Imino Rhodium Carbene Precursors.
Authors: Xing Yanpeng , Sheng Guorong , Wang Jing , Lu Ping , Wang Yanguang 
Published: July 2014

AbstractTitle compounds (III) and (V) are efficiently prepared via a tandem catalysis process involving intramolecular ligand stabilized CuAAC and Cu‐catalyzed C—N coupling.
ChemInform Abstract: Rapid Synthesis of Fused N‐Heterocycles by Transition‐Metal‐Free Electrophilic Amination of Arene C—H Bonds.
Authors: Gao Hongyin , Xu Qing‐Long , Yousufuddin Muhammed , Ess Daniel H. , Kuerti Laszlo 
Published: July 2014

AbstractThe synthesis of fused N‐heterocycles starting from readily available 2‐nitrobiaryls and phenylmagnesium bromide is disclosed.
ChemInform Abstract: Highly Active Aluminum Catalysts for the Formation of Organic Carbonates from CO2 and Oxiranes.
Authors: Whiteoak Christopher J. , Kielland Nicola , Laserna Victor , Castro‐Gomez Fernando , Martin Eddy , Escudero‐Adan Eduardo C. , Bo Carles , Kleij Arjan W. 
Published: July 2014

AbstractAl(III) complexes of amino‐tris(phenolate) ligand scaffolds (I) are prepared to attain effective Lewis acidic catalysts.
ChemInform Abstract: Full Functionalization of the Imidazole Scaffold by Selective Metalation and Sulfoxide/Magnesium Exchange.
Authors: Saemann Christoph , Coya Estibaliz , Knochel Paul 
Published: July 2014

AbstractThis describes the stepwise regioselective functionalization of the three carbon atoms of the imidazole scaffold with electrophiles followed by an N‐methylation.
ChemInform Abstract: 2‐Substituted Thiazole‐4‐carboxamide Derivatives as Tiazofurin Mimics: Synthesis and in vitro Antitumor Activity.
Authors: Popsavin Mirjana , Kojic Vesna , Spaic Sasa , Svircev Milos , Bogdanovic Gordana , Jakimov Dimitar , Aleksic Lidija , Popsavin Velimir 
Published: July 2014

AbstractTitle compounds (I) ‐ (III) are prepared by multistep sequences starting from D‐xylose or D‐arabinose, respectively.
ChemInform Abstract: Iridium‐Catalyzed Intermolecular Azide—Alkyne Cycloaddition of Internal Thioalkynes under Mild Conditions.
Authors: Ding Shengtao , Jia Guochen , Sun Jianwei 
Published: July 2014

AbstractSeveral other alkynes such as diethyl and diphenylacetylene are shown to be unreactive.
ChemInform Abstract: Palladium and Copper‐Supported on Charcoal: A Heterogeneous Multi‐Task Catalyst for Sequential Sonogashira—Click and Click—Heck Reactions.
Authors: Rossy Cybille , Majimel Jerome , Delapierre Mona Treguer , Fouquet Eric , Felpin Francois‐Xavier 
Published: July 2014

AbstractPalladium and copper‐supported on charcoal represent a new multi‐task catalyst for the one‐pot synthesis of functionalized triazoles and triazolo[5,1‐a]isoindoles.
ChemInform Abstract: Lewis Base‐Catalyzed Divergent Isomerizations of 5‐Hydroxyl‐2,3‐dienoate.
Authors: Dong Wei , Hu Pengfei , Hu Jian , Tong Xiaofeng 
Published: July 2014

AbstractTriphenylphosphine‐promoted isomerization of the title compounds (I) results in formation of a mixture of 5‐oxohexenoates (II) and (III) while DABCO as promotor gives lactones (V) as products.
ChemInform Abstract: Intramolecular Cascade Lactone Cyclization of Dicoumarol Derivatives Promoted by Tributyltin Chloride.
Authors: Rehman Sadia , Ikram Muhammad , Subhan Fazle 
Published: July 2014

AbstractA novel catalytic route for the cyclization of dicumarols to obtain pyran derivatives using a tin organometallic compound as catalyst is reported.
ChemInform Abstract: Hydrogenative Dearomatization of Pyridine and an Asymmetric Aza‐Friedel—Crafts Alkylation Sequence.
Authors: Wang Shuo‐Guo , You Shu‐Li 
Published: July 2014

AbstractA new synthetic route to enantioenriched pyridine derivatives is presented using a chiral phosphoric acid as catalyst.
ChemInform Abstract: Multicomponent Reactions for Diverse Synthesis of N‐Substituted and NH 1,4‐Dihydropyridines.
Authors: Wan Jieping , Zhou Youyi , Liu Yunyun , Fang Zheng , Wen Chengping 
Published: July 2014

AbstractA number of symmetrical N‐substituted or N‐unsubstituted 1,4‐dihydropyridines are obtained by multicomponent reactions of various aromatic aldehydes, electron deficient alkynes, and NH4OAc or amines, respectively
ChemInform Abstract: Synthesis of Novel 5‐(3‐Alkylquinolin‐2‐yl)‐3‐aryl Isoxazole Derivatives and Their Cytotoxic Activity.
Authors: Sambasiva Rao P. , Kurumurthy C. , Veeraswamy B. , Poornachandra Y. , Ganesh Kumar C. , Narsaiah B. 
Published: July 2014

AbstractAll the final products are screened against four human cancer cell lines.
ChemInform Abstract: α‐MsO/TsO/Cl Ketones as Oxidized Alkyne Equivalents: Redox‐Neutral Rhodium(III)‐Catalyzed C—H Activation for the Synthesis of N‐Heterocycles.
Authors: Yu Da‐Gang , de Azambuja Francisco , Glorius Frank 
Published: July 2014

AbstractFor the first time, α‐pseudohalo and α‐halo ketones are utilized as oxidized alkyne equivalents in Rh(III)‐catalyzed redox‐neutral annulations to efficiently generate diverse N‐heterocycles.
ChemInform Abstract: An Enantioselective Inverse‐Electron‐Demand Imino Diels—Alder Reaction.
Authors: Eschenbrenner‐Lux Vincent , Kuechler Philipp , Ziegler Slava , Kumar Kamal , Waldmann Herbert 
Published: July 2014

AbstractThe title reaction leads to racemic products employing ZnCl2 as the catalyst.
ChemInform Abstract: Catalyst‐ and Solvent‐Free, Pot, Atom and Step Economic Synthesis of Tetrahydroquinazolines by an Aza‐Diels—Alder Reaction Strategy.
Authors: Bhuyan Debajyoti , Sarma Rupam , Dommaraju Yuvaraj , Prajapati Dipak 
Published: July 2014

AbstractThe microwave‐assisted aza‐Diels—Alder reaction of 2‐naphthylamine (I) with aryl aldehydes (II) and ammonium acetate leads to desired bis‐aryl tetrahydroquinazolines (III) in good yields.
ChemInform Abstract: [1,5]‐Anion Relay via Intramolecular Proton Transfer to Generate 3,3‐Bis(silyl) Allyloxy Lithium: A Useful Scaffold for Syn‐Addition to Aldehydes and Ketones.
Authors: Lin Xinglong , Ye Xincui , Sun Xianwei , Zhang Yuebao , Gao Lu , Song Zhenlei 
Published: July 2014

AbstractThe reaction proceeds via [1,5]‐anion relay in 3,3‐bis(silyl) benzyl enol ether.
ChemInform Abstract: Copper‐Catalyzed α‐Amination of Phosphonates and Phosphine Oxides: A Direct Approach to α‐Amino Phosphonic Acids and Derivatives.
Authors: McDonald Stacey L. , Wang Qiu 
Published: July 2014

AbstractThe reaction represents the first example of C—N bond formation which directly introduces cyclic and acyclic amines to the α‐position of phosphonates in one step.
ChemInform Abstract: Turning Regioselectivity into Stereoselectivity: Efficient Dual Resolution of P‐Stereogenic Phosphine Oxides Through Bifurcation of the Reaction Pathway of a Common Intermediate.
Authors: Nikitin Kirill , Rajendran Kamalraj V. , Mueller‐Bunz Helge , Gilheany Declan G. 
Published: July 2014

AbstractThe method represents the first example for a dual chiral resolution of a racemic substrate being based on stereochemical bifurcation of an intermediate obtained with a single chiral auxiliary.
ChemInform Abstract: Dialkylation of Diethyl Ethoxycarbonylmethylphosphonate under Microwave and Solventless Conditions.
Authors: Gruen Alajos , Blastik Zsofia , Drahos Laszlo , Keglevich Gyoergy 
Published: July 2014

AbstractA multistep microwave‐assisted, solvent‐ and catalyst‐free method for the 2,2‐Dialkylation of the title methylphosphonate (I) is developed.
ChemInform Abstract: New Cytotoxic Halogenated Sesquiterpenes from the Egyptian Sea Hare, Aplysia oculifera.
Authors: Hegazy Mohamed‐Elamir F. , Moustfa Alaa Y. , Mohamed Abou El‐Hamd H. , Alhammady Montaser A. , Elbehairi Serag Eldin I. , Ohta Shinji , Pare Paul W. 
Published: July 2014

AbstractOculiferane (I) and epi‐obtusane (II) are isolated from the sea hare and show cytotoxic activities against several human cancer cell lines.
ChemInform Abstract: Penicillitone, a Potent in vitro Antiinflammatory and Cytotoxic Rearranged Sterol with an Unusual Tetracycle Core Produced by Penicillium purpurogenum.
Authors: Xue Jinghua , Wu Ping , Xu Liangxiong , Wei Xiaoyi 
Published: July 2014

AbstractAdditionally the new compound penicillisterol (II) is found.
ChemInform Abstract: Structure Elucidation and Total Synthesis of Kulkenon.
Authors: Symkenberg Gerrit , Kalesse Markus 
Published: July 2014

AbstractA combination of molecular modeling and NOE experiments is used to establish the revised configuration of (I) which is confirmed by its synthesis having a syn‐selective vinylogous Kobayashi aldol reaction and an intramolecular Heck reaction as pivotal transformations.
ChemInform Abstract: Collective Synthesis of Cladiellins Based on the Gold‐Catalyzed Cascade Reaction of 1,7‐Diynes.
Authors: Yue Guozong , Zhang Yun , Fang Lichao , Li Chuang‐chuang , Luo Tuoping , Yang Zhen 
Published: July 2014

AbstractThe Cladiellin family comprises (‐)‐Scelerophytin A (Ia), (‐)‐Scelerophytin B (Ib), (+)‐Deacetylpolyanthellin A (IIa), (+)‐Polyanthellin A (IIb), (+)‐Cladiella‐6Z,11(17)‐dien‐3‐ol (III), (+)‐Vigulariol (IV), (‐)‐Cladiellisin (Va), (‐)‐Pachycladin C (Vb) and (‐)‐Pachycladin D (VI).
ChemInform Abstract: Energy Transfer from Bi3+ to Ho3+ Triggers Brilliant Single Green Light Emission in LaNbTiO6:Ho3+, Bi3+ Phosphors.
Authors: Zhang Xingshuang , Zhou Guangjun , Zhou Juan , Zhou Haifeng , Kong Peng , Yu Zhichao , Zhan Jie 
Published: July 2014

AbstractPure and Ho3+, Bi3+ co‐doped LaNbTiO6 phosphors are synthesized by a sol—gel and combustion method using La2O3, Ho2O3, Bi(NO3)3, Nb2O5, Ti(O‐Bu)4, HNO3, HF, NH4NO3, and citric acid as starting materials.
ChemInform Abstract: Significant Enhancement in Photocatalytic Reduction of Water to Hydrogen by Au/Cu2ZnSnS4Nanostructure.
Authors: Ha Enna , Lee Lawrence Yoon Suk , Wang Jingchuan , Li Fenghua , Wong Kwok‐Yin , Tsang Shik Chi Edman 
Published: July 2014

AbstractAu/Cu2ZnSnS4 core/shell nanoparticles are prepared by injection of mixtures of Cu(OAc)2, Zn(OAc)2, and Sn(OAc)2 in oleylamine into a solution of HAuCl4 in oleylamine followed by injection of a 1‐dodecanethiol/tert‐dodecanethiol mixture (280 °C, 30 min).
ChemInform Abstract: Total Synthesis of the Antimitotic Marine Macrolide (‐)‐Leiodermatolide.
Authors: Paterson Ian , Ng Kenneth K.‐H. , Williams Simon , Millican David C. , Dalby Stephen M. 
Published: July 2014

AbstractA highly stereocontrolled total synthesis of (‐)‐leiodermatolide (I) is reported.
ChemInform Abstract: Stereospecific Intra‐Molecular Interligand Interactions Affecting Base‐Specific Metal Bonding to Purine Nucleobases in the Solid State
Authors: Aoki Katsuyuki , Fujisawa Ikuhide , Murayama Kazutaka , Hu Ning‐Hai 
Published: July 2014

AbstractReview: 236 refs.
A model and nomogram to predict tumor site origin for squamous cell cancer confined to cervical lymph nodes
Authors: Ali Arif N. , Switchenko Jeffrey M. , Kim Sungjin , Kowalski Jeanne , El‐Deiry Mark W. , Beitler Jonathan J. 
Published: July 2014

BACKGROUNDThe current study was conducted to develop a multifactorial statistical model to predict the specific head and neck (H&N) tumor site origin in cases of squamous cell carcinoma confined to the cervical lymph nodes (“unknown primaries”).METHODSThe Surveillance, Epidemiology, and End Results (SEER) database was analyzed for patients with an H&N tumor site who were diagnosed between 2004 and 2011. The SEER patients were identified according to their H&N primary tumor site and clinically positive cervical lymph node levels at the time of presentation. The SEER patient data set was randomly divided into 2 data sets for the purposes of internal split‐sample validation. The effects of cervical lymph node levels, age, race, and sex on H&N primary tumor site were examined using univariate and multivariate analyses. Multivariate logistic regression models and an associated set of nomograms were developed based on relevant factors to provide probabilities of tumor site origin.RESULTSAnalysis of the SEER database identified 20,011 patients with H&N disease with both site‐level and lymph node‐level data. Sex, race, age, and lymph node levels were associated with primary H&N tumor site (nasopharynx, hypopharynx, oropharynx, and larynx) in the multivariate models. Internal validation techniques affirmed the accuracy of these models on separate data.CONCLUSIONSThe incorporation of epidemiologic and lymph node data into a predictive model has the potential to provide valuable guidance to clinicians in the treatment of patients with squamous cell carcinoma confined to the cervical lymph nodes. Cancer 2014;120:3469–3476. © 2014 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
The role of cytopathology and cyst fluid analysis in the preoperative diagnosis and management of pancreatic cysts >3 cm
Authors: Chebib Ivan , Yaeger Kurt , Mino‐Kenudson Mari , Pitman Martha B. 
Published: July 2014

BACKGROUNDPancreatic cyst size >3 cm is a worrisome rather than high‐risk feature for malignancy based on the 2012 International Guidelines for the management of mucinous cysts. The value of cytology in preoperative evaluation and surgical triage is unclear.METHODSAll pancreatic cysts >3 cm resected over a 7‐year period were evaluated for clinical, radiologic, and pathologic information. Performance of cytology for the detection of malignancy and surgical triage compared with imaging was assessed.RESULTSThere were 93 histologically confirmed cysts, 52 of which were mucinous and 41 of which were nonmucinous. Of these, 37% were malignant, including 16 nonmucinous malignancies and 18 mucinous cysts (12 with invasive carcinoma, 6 with high‐grade dysplasia). Thirty‐nine cysts (41% malignant, 59% benign) were not subject to endoscopic ultrasound‐fine needle aspiration (EUS‐FNA) prior to resection (average size, 6.0 cm). Fifty‐four were evaluated by EUS‐FNA, with 35 available for review (average size, 5.4 cm). Cytology/cyst fluid analysis had the highest specificity (88.9%) compared with imaging, whereas magnetic resonance imaging (MRI) showed the highest sensitivity (100%). MRI had the highest predictive value for mucinous (100%) versus nonmucinous cysts (100%). MRI and EUS were able to predict malignancy from the presence of high‐risk imaging features in all cases. Some benign cases also showed high‐risk imaging features on MRI (28.6%), computed tomography (32.3%), and EUS (45.8%). Cytology correctly classified 5 of 6 benign cysts with high‐risk imaging as benign.CONCLUSIONSPreoperative evaluation of pancreatic cysts >3 cm is warranted, as many are nonmucinous cysts and not high‐grade. Cytology is more specific than imaging for the detection of malignancy in cysts >3 cm. Cancer (Cancer Cytopathol) 2014;122:804–809. © 2014 American Cancer Society.
Blue Luminescence of Dendrimer‐Encapsulated Gold Nanoclusters
Authors: Kim Jun Myung , Sohn So Hyeong , Han Noh Soo , Park Seung Min , Kim Joohoon , Song Jae Kyu 
Published: July 2014

AbstractDirect evidence for the blue luminescence of gold nanoclusters encapsulated inside hydroxyl‐terminated polyamidoamine (PAMAM) dendrimers was provided by spectroscopic studies as well as by theoretical calculations. Steady‐state and time‐resolved spectroscopic studies showed that the luminescence of the gold nanoclusters consisted largely of two electronic transitions. Theoretical calculations indicate that the two transitions are attributed to the different sizes of the gold nanoclusters (Au8 and Au13). The luminescence of the gold nanoclusters was clearly distinguished from that of the dendrimers.
Tungsten Carbide–Nitride on Graphene Nanoplatelets as a Durable Hydrogen Evolution Electrocatalyst
Authors: Chen Wei‐Fu , Schneider Jonathan M. , Sasaki Kotaro , Wang Chiu‐Hui , Schneider Jacob , Iyer Shilpa , Iyer Shweta , Zhu Yimei , Muckerman James T. , Fujita Etsuko 
Published: July 2014

AbstractAlternatives to platinum‐based catalysts are required to sustainably produce hydrogen from water at low overpotentials. Progress has been made in utilizing tungsten carbide‐based catalysts, however, their performance is currently limited by the density and reactivity of active sites, and insufficient stability in acidic electrolytes. We report highly active graphene nanoplatelet‐supported tungsten carbide–nitride nanocomposites prepared via an in situ solid‐state approach. This nanocomposite catalyzes the hydrogen evolution reaction with very low overpotential and is stable operating for at least 300 h in harsh acidic conditions. The synthetic approach offers a great advantage in terms of structural control and kinetics improvement.
Rebalancing Climate Change Debate and Policy: An Analysis of Online Discussions
Authors: Martin Nigel , Rice John 
Published: July 2014

ABSTRACTPublic participation in environmental policy development offers governments and private organizations opportunities to gather community views and test policy instruments and solutions. In this study, a concept mapping analysis of 1702 online comments from 344 individuals has been undertaken to determine the balance between climate change debate and policy development, and some of the major issues surrounding policy implementation. The results show that counterproductive and intolerant climate science debate, opposing political party policy alignments, and disagreement on policy implementation serve as impediments in developing workable climate change policy. The research also exposes how individuals can ‘hijack’ the online discussion forums in attempts to further their own agendas. This suggests that online forums might be better designed to integrate with the larger policy development system. Copyright © 2014 John Wiley & Sons, Ltd and ERP Environment
Rationale and design of the SOluble guanylate Cyclase stimulatoR in heArT failurE Studies (SOCRATES)
Authors: Pieske Burkert , Butler Javed , Filippatos Gerasimos , Lam Carolyn , Maggioni Aldo Pietro , Ponikowski Piotr , Shah Sanjiv , Solomon Scott , Kraigher‐Krainer Elisabeth , Samano Eliana Tibana , Scalise Andrea Viviana , Müller Katharina , Roessig Lothar , Gheorghiade Mihai ,   on behalf of the SOCRATES Investigators and Coordinators
Published: July 2014

AimsThe clinical outcomes for patients with worsening chronic heart failure (WCHF) remain exceedingly poor despite contemporary evidence‐based therapies, and effective therapies are urgently needed. Accumulating evidence supports augmentation of cyclic guanosine monophosphate (cGMP) signalling as a potential therapeutic strategy for HF with reduced or preserved ejection fraction (HFrEF and HFpEF, respectively). Direct soluble guanylate cyclase (sGC) stimulators target reduced cGMP generation due to insufficient sGC stimulation and represent a promising method for cGMP enhancement.MethodsThe phase II SOluble guanylate Cyclase stimulatoR in heArT failurE Study (SOCRATES) programme consists of two randomized, parallel‐group, placebo‐controlled, double‐blind, multicentre studies, SOCRATES‐REDUCED (in patients with LVEF <45%) and SOCRATES‐PRESERVED (in those with LVEF ≥45%), that will explore the pharmacodynamic effects, safety and tolerability, and pharmacokinetics of four dose regimens of the once‐daily oral sGC stimulator vericiguat (BAY 1021189) over 12 weeks compared with placebo. These studies will enrol patients stabilized during hospitalization for HF at the time of discharge or within 4 weeks thereafter. The primary endpoint in SOCRATES‐REDUCED is change in NT‐proBNP at 12 weeks. The primary endpoints in SOCRATES‐PRESERVED are change in NT‐proBNP and left atrial volume at 12 weeks.PerspectivesSOCRATES will be the first programme to enrol specifically both inpatients and outpatients with WCHF and patients with reduced or preserved ejection fraction. Results will inform the benefits of pursuing subsequent event‐driven clinical outcome trials with sGC stimulators in this patient population.Trial registrationNCT01951625 (SOCRATES‐REDUCED) and NCT01951638 (SOCRATES‐PRESERVED)
Randall Selitto pressure algometry for assessment of bone‐related pain in rats
Authors: Falk S. , Ipsen D.H. , Appel C.K. , Ugarak A. , Durup D. , Dickenson A.H. , Heegaard A.M. 
Published: July 2014

AbstractBackgroundDeep pain is neglected compared with cutaneous sources. Pressure algometry has been validated in the clinic for assessment of bone‐related pain in humans. In animal models of bone‐related pain, we have validated the Randall Selitto behavioural test for assessment of acute and pathological bone pain and compared the outcome with more traditional pain‐related behaviour measures.MethodsRandall Selitto pressure algometry was performed over the anteromedial part of the tibia in naïve rats, sham‐operated rats, and rats inoculated with MRMT‐1 carcinoma cells in the left tibia, and the effect of morphine was investigated. Randall Selitto measures of cancer‐induced bone pain were supplemented by von Frey testing, weight‐bearing and limb use test. Contribution of cutaneous nociception to Randall Selitto measures were examined by local anaesthesia.ResultsRandall Selitto pressure algometry over the tibia resulted in reproducible withdrawal thresholds, which were dose‐dependently increased by morphine. Cutaneous nociception did not contribute to Randall Selitto measures. In cancer‐bearing animals, compared with sham, significant differences in pain‐related behaviours were demonstrated by the Randall Selitto test on day 17 and 21 post‐surgery. A difference was also demonstrated by von Frey testing, weight‐bearing and limb use tests.ConclusionOur results indicate that pressure applied by the Randall Selitto algometer on a region, where the bone is close to the skin, may offer a way to measure bone‐related pain in animal models and could provide a supplement to the traditional behavioural tests and a means to study deep pain.
Care‐related pain in hospitalized patients: Severity and patient perception of management
Authors: Ambrogi V. , Tezenas du Montcel S. , Collin E. , Coutaux A. , Bourgeois P. , Bourdillon F. 
Published: July 2014

AbstractBackgroundHospitalized patients commonly undergo painful procedures, but little is known about care‐related pain (CRP) in the overall population of inpatients. We conducted a cross‐sectional 1‐day survey to assess the prevalence and characteristics of CRP and its management in all units of a university hospital in Paris and determined the factors linked to severe CRP.MethodsAll patients who were able to communicate and were hospitalized for at least 24 h but not in a day‐care or neonatal unit were included.ResultsFrom 938 patients who completed the questionnaire, 554 patients reported pain within the previous 24 h, for a 59% prevalence of pain, and 540 (58%) had experienced CRP in the previous 15 days (51% males; mean [SD] age 54 [18] years). Of 907 procedures, 330 (37%) resulted in severe pain. The most‐often reported painful procedures were vascular punctures and patient mobilization. Severe CRP was associated with long hospitalization; non‐vascular invasive punctures, catheterization, mobilization or radiological examination; or pain during the previous 24 h due to surgery or treatment. Only half of the patients declared that they had received information regarding the painful procedure. Treatment for pain was proposed and delivered in less than one quarter of cases.ConclusionsOur results of a survey of pain management in hospitalized patients relate to a wide variety of medical conditions and procedures. Health‐care workers should be more systematic in managing CRP, and attention should be paid to patients at greatest risk of severe CRP.