bluuebunny/crossref_metadata_2025_split huggingface dataset:
A mother and daughter with a novel phenotype of hand and foot abnormalities and severe pectus excavatum
Authors: Low Karen , Smith James , Lee Simon , Newbury‐Ecob Ruth 
Published: July 2013

AbstractA mother and daughter with an overlapping Catel–Manzke and Temtamy preaxial brachydactyly hyperphalangism syndrome phenotype are reported. We describe a phenotype with a previously undescribed genetic basis. © 2013 Wiley Periodicals, Inc.
Homozygous deletion in TUSC3 causing syndromic intellectual disability: A new patient
Authors: Loddo Sara , Parisi Valentina , Doccini Viola , Filippi Tiziana , Bernardini Laura , Brovedani Paola , Ricci Federica , Novelli Antonio , Battaglia Agatino 
Published: July 2013

AbstractDefects in the TUSC3 gene have been identified in individuals with nonsyndromic autosomal recessive intellectual disability (ARID), due to either point mutations or intragenic deletions. We report on a boy with a homozygous microdeletion 8p22, sizing 203 kb, encompassing the first exon of the TUSC3 gene, detected by SNP‐array analysis (Human Gene Chip 6.0; Affymetrix). Both nonconsanguineous parents come from a small Sicilian village and were heterozygous carriers of the microdeletion. The propositus had a few dysmorphic features and a moderate cognitive impairment. Verbal communication was impaired, with an inappropriate phonetic inventory, important phono‐articolatory distortions, and bucco‐phonatory dyspraxia. Comprehension was possible for simple sentences. Behavior was characterized by motor instability, high tendency to irritability and distraibility, anxiety traits, and an oppositional‐defiant disorder. His parents were of normal intelligence. TUSC3 is thought to encode a subunit of the endoplasmic reticulum‐bound oligosaccharyltranferase complex that catalyzes a pivotal step in the protein N‐glycosylation process. TUSC3 has been recently reported as a member of the plasma membrane Mg2+ transport system, with a possible involvement in learning abilities, working memory and short‐ and long‐term memory. This is the third family in which a deletion has been described. Although the pathogenic mechanism has not been clarified yet, our report argues for a more prominent role of TUSC3 in the etiology of intellectual disability and that deletions encompassing this gene could be more common than expected. © 2013 Wiley Periodicals, Inc.
Structural and optical properties of Cu‐doped ZnS nanoparticles formed in chitosan/sodium alginate multilayer films
Authors: Wang Liping , Sun Yujie , Xie Xiaodong 
Published: July 2013

ABSTRACTChitosan/alginate multilayers were fabricated using a spin‐coating method, and ZnS:Cu nanoparticles were generated within the network of two natural polysaccharides, chitosan and sodium alginate. The synthesized nanoparticles were characterized using an X‐ray diffractometer (XRD), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS) and atomic force microscopy (AFM). The results showed that cubic zinc blende‐structured ZnS:Cu nanoparticles with an average crystal size of ~ 3 nm were uniformly distributed. UV–vis spectra indicate a large quantum size effect and the absorption edge for the ZnS:Cu nanoparticles slightly shifted to longer wavelengths with increasing Cu ion concentrations. The photoluminescence of the Cu‐doped ZnS nanoparticles reached a maximum at a 1% doping level. The ZnS:Cu nanoparticles form and are distributed uniformly in the composite multilayer films with a surface average height of 25 nm. Copyright © 2013 John Wiley & Sons, Ltd.
A historical account of hoogsteen base‐pairs in duplex DNA
Authors: Nikolova Evgenia N. , Zhou Huiqing , Gottardo Federico L. , Alvey Heidi S. , Kimsey Isaac J. , Al‐Hashimi Hashim M. 
Published: July 2013

ABSTRACTIn 1957, a unique pattern of hydrogen bonding between N3 and O4 on uracil and N7 and N6 on adenine was proposed to explain how poly(rU) strands can associate with poly(rA)‐poly(rU) duplexes to form triplexes. Two years later, Karst Hoogsteen visualized such a noncanonical A–T base‐pair through X‐ray analysis of co‐crystals containing 9‐methyladenine and 1‐methylthymine. Subsequent X‐ray analyses of guanine and cytosine derivatives yielded the expected Watson–Crick base‐pairing, but those of adenine and thymine (or uridine) did not yield Watson–Crick base‐pairs, instead favoring “Hoogsteen” base‐pairing. More than two decades ensued without experimental “proof” for A–T Watson–Crick base‐pairs, while Hoogsteen base‐pairs continued to surface in AT‐rich sequences, closing base‐pairs of apical loops, in structures of DNA bound to antibiotics and proteins, damaged and chemically modified DNA, and in polymerases that replicate DNA via Hoogsteen pairing. Recently, NMR studies have shown that base‐pairs in duplex DNA exist as a dynamic equilibrium between Watson–Crick and Hoogsteen forms. There is now little doubt that Hoogsteen base‐pairs exist in significant abundance in genomic DNA, where they can expand the structural and functional versatility of duplex DNA beyond that which can be achieved based only on Watson–Crick base‐pairing. Here, we provide a historical account of the discovery and characterization of Hoogsteen base‐pairs, hoping that this will inform future studies exploring the occurrence and functional importance of these alternative base‐pairs. © 2013 Wiley Periodicals, Inc. Biopolymers 99: 955–968, 2013.
Synthesis of Glycans and Glycopolymers Through Engineered Enzymes
Authors: Armstrong Zachary , Withers Stephen G. 
Published: July 2013

ABSTRACTThe synthesis of defined glycans enables us to further understand their roles in a biological context. Although useful chemical methods have been developed for the synthesis of glycans, these typically require complex protection and deprotection steps along with challenging control of anomeric stereochemistry. Enzymatic methods offer an attractive alternative to chemical synthesis. In particular, the use of glycosynthases and thioglycoligases, classes of engineered glycoside hydrolases, offers an enticing approach to the stereo‐ and regioselective synthesis of glycans without the need for protecting groups. Herein, we describe recent progress in the use of glycosynthases and thioglycoligases for the synthesis of glycans and glycopolymers. © 2013 Wiley Periodicals, Inc. Biopolymers 99: 666–674, 2013.
Histone‐Deacetylase‐Targeted Fluorescent Ruthenium(II) Polypyridyl Complexes as Potent Anticancer Agents
Authors: Ye Rui‐Rong , Ke Zhuo‐Feng , Tan Cai‐Ping , He Liang , Ji Liang‐Nian , Mao Zong‐Wan 
Published: July 2013

AbstractHistone deacetylases inhibitors (HDACis) have gained much attention as a new class of anticancer agents in recent years. Herein, we report a series of fluorescent ruthenium(II) complexes containing N1‐hydroxy‐N8‐(1,10‐phenanthrolin‐5‐yl)octanediamide (L), a suberoylanilide hydroxamic acid (SAHA) derivative, as a ligand. As expected, these complexes show interesting chemiphysical properties, including relatively high quantum yields, large Stokes shifts, and long emission lifetimes. The in vitro inhibitory effect of the most effective drug, [Ru(DIP)2L](PF6)2 (3; DIP: 4,7‐diphenyl‐1,10‐phenanthroline), on histone deacetylases (HDACs) is approximately equivalent in activity to that of SAHA, and treatment with complex 3 results in increased levels of the acetylated histone H3. Complex 3 is highly active against a panel of human cancer cell lines, whereas it shows relatively much lower toxicity to normal cells. Further mechanism studies show that complex 3 can elicit cell cycle arrest and induce apoptosis through mitochondria‐related pathways and the production of reactive oxygen species. These data suggest that these fluorescent ruthenium(II)–HDACi conjugates may represent a promising class of anticancer agents for potential dual imaging and therapeutic applications targeting HDACs.
Syntheses and Properties of Graphyne Fragments: Trigonally Expanded Dehydrobenzo[12]annulenes
Authors: Tahara Kazukuni , Yamamoto Yuki , Gross Dustin E. , Kozuma Hiroyoshi , Arikuma Yoko , Ohta Koji , Koizumi Yoshiko , Gao Yuan , Shimizu Yo , Seki Shu , Kamada Kenji , Moore Jeffrey S. , Tobe Yoshito 
Published: July 2013

AbstractWe present herein the synthesis and properties of the largest hitherto unknown graphyne fragment, namely trigonally expanded tetrakis(dehydrobenzo[12]annulene)s (tetrakis‐DBAs). Intramolecular three‐fold alkyne metathesis reactions of hexakis(arylethynyl)DBAs 9 a and 9 b using Fürstner’s Mo catalyst furnished tetrakis‐DBAs 8 a and 8 b substituted with tert‐butyl or branched alkyl ester groups in moderate and fair yields, respectively, demonstrating that the metathesis reaction of this protocol is a powerful tool for the construction of graphyne fragment backbones. For comparison, hexakis(arylethynyl)DBAs 9 c–g have also been prepared. The one‐photon absorption spectrum of tetrakis‐DBA 8 a bearing tert‐butyl groups revealed a remarkable bathochromic shift of the absorption cut‐off (λcutoff) compared with those of previously reported graphyne fragments due to extended π‐conjugation. Moreover, in the two‐photon absorption spectrum, 8 a showed a large cross‐section for a pure hydrocarbon because of the planar para‐phenylene‐ethynylene conjugation pathways. Hexakis(arylethynyl)‐DBAs 9 c–e and 9 g and tetrakis‐DBA 8 b bearing electron‐withdrawing groups aggregated in chloroform solutions. Comparison between the free energies of 9 e and 8 b bearing the same substituents revealed the more favorable association of the latter due to stronger π–π interactions between the extended π‐cores. Polarized optical microscopy observations, DSC, and XRD measurements showed that 8 b and 9 e with branched alkyl ester groups displayed columnar rectangular mesophases. By the time‐resolved microwave conductivity method, the columnar rectangular phase of 8 b was shown to exhibit a moderate charge‐carrier mobility of 0.12 cm2 V−1 s−1. These results indicate that large graphyne fragments can serve as good organic semiconductors.
Synthesis and Structural Characterization of Hexacoordinate Silicon, Germanium, and Titanium Complexes of the E. coli Siderophore Enterobactin
Authors: Baramov Todor , Keijzer Karlijn , Irran Elisabeth , Mösker Eva , Baik Mu‐Hyun , Süssmuth Roderich 
Published: July 2013

AbstractThe E. coli siderophore enterobactin, one of the strongest FeIII chelators known to date, is also capable of binding SiIV under physiological conditions. We report on the synthesis and structural characterization of the tris(catecholate) SiIV–enterobactin complex and its GeIV and TiIV analogues. Comparative structural analysis, supported by quantum‐chemical calculations, reveals the correlation between the ionic radius and the structural changes in enterobactin upon complexation.
ChemInform Abstract: Exploring a New Structure Family: Alkali Borosulfates Na5[B(SO4)4], A3[B(SO4)3] (A: K, Rb), Li[B(SO4)2], and Li[B(S2O7)2].
Authors: Daub Michael , Kazmierczak Karolina , Gross Peter , Hoeppe Henning , Hillebrecht Harald 
Published: July 2013

AbstractThe crystal structures of the title compounds are based on corner‐linked BO4 and SO4 tetrahedra with varying coordination of the alkali cations.
ChemInform Abstract: A Deacetylation—Diazotation—Coupling Sequence: Palladium‐Catalyzed C—C Bond Formation with Acetanilides as Formal Leaving Groups.
Authors: Schmidt Bernd , Berger Rene 
Published: July 2013

AbstractAcetanilides (I), (VI), and (VIII) can be deacetylated and diazotized in situ, and subsequently used in Pd‐catalyzed coupling reactions without isolation of the diazonium intermediate.
ChemInform Abstract: CuBr2‐Promoted Tetrahydrofuranylation of Alcohols and 1,3‐Dione.
Authors: Wang Meng‐Ke , Zhou Zeng‐le , Tang Ri‐Yuan , Zhang Xing‐Guo , Deng Chen‐liang 
Published: July 2013

AbstractThe mild conditions can be applied to a broad spectrum of alcohol substrates and extended to phenol (XIII) and dione (XV).
ChemInform Abstract: An Efficient Synthesis of N‐Cyclopropylanilines by a Smiles Rearrangement.
Authors: Arava Veera Reddy , Bandatmakuru Sreenivasula Reddy 
Published: July 2013

Abstract2‐Aryloxy‐N‐cyclopropylacetamides can be readily prepared from phenols and 2‐chloro‐N‐cyclopropylamide (III).
ChemInform Abstract: An Operationally Simple Approach to (E)‐α‐Halo Vinyl Sulfides and Their Applications for Accessing Stereodefined Trisubstituted Alkenes.
Authors: Yang Zhaozhen , Chen Xiaoyi , Kong Wei , Xia Siyuan , Zheng Renwei , Luo Fang , Zhu Gangguo 
Published: July 2013

AbstractA highly regio‐ and stereoselective hydrohalogenation of alkynyl thioethers leads to (E)‐α‐halo vinyl sulfides (II).
ChemInform Abstract: Optically Active 2,3‐Allenoates via Palladium‐Catalyzed Carbonylation of Enantioenriched Propargylic Mesylates.
Authors: Wang Yuli , Ma Shengming 
Published: July 2013

AbstractThe reaction allows to introduce various alkyl‐, allyl‐ and benzyl substituents in the desired optically active allene derivatives.
ChemInform Abstract: N(2)‐Monosubstituted Bishydrazides of Oxalic Acid as New Efficient Components of the System for the Copper‐Catalyzed C—N Cross‐Coupling in Water.
Authors: Kurandina D. V. , Eliseenkov E. V. , Petrov A. A. , Boyarskiy V. P. 
Published: July 2013

AbstractA scaled preparative method for the synthesis of diarylamines is developed.
ChemInform Abstract: Microwave‐Assisted Amidation of Arylacetic Acids by Reaction with 2‐Aryl‐ethylamines
Authors: Gruen Alajos , Milen Matyas , Foeldesi Tamas , Abranyi‐Balogh Peter , Drahos Laszlo , Keglevich Gyoergy 
Published: July 2013

Abstract25 examples
ChemInform Abstract: Palladium‐Catalyzed Decarboxylative Acylation of O‐Phenyl Carbamates with α‐Oxocarboxylic Acids at Room Temperature.
Authors: Sharma Satyasheel , Kim Aejin , Park Eonjeong , Park Jihye , Kim Minyoung , Kwak Jong Hwan , Lee Sang Hwi , Jung Young Hoon , Kim In Su 
Published: July 2013

AbstractThe described approach represents the first ortho‐acylation of the phenol derivatives.
ChemInform Abstract: Rhodium(I)‐Catalyzed Redox‐Economic Cross‐Coupling of Carboxylic Acids with Arenes Directed by N‐Containing Groups.
Authors: Pan Fei , Lei Zhi‐Quan , Wang Hui , Li Hu , Sun Jian , Shi Zhang‐Jie 
Published: July 2013

AbstractThe pseudo‐oxidative decarboxylative coupling of carboxylic acids and arenes using a rhodium(I)‐catalyst is described.
ChemInform Abstract: Remote Anionic Fries Rearrangement of Sulfonates: Regioselective Synthesis of Indole Triflones.
Authors: Xu Xiu‐Hua , Taniguchi Misaki , Azuma Ayaka , Liu Guo Kai , Tokunaga Etsuko , Shibata Norio 
Published: July 2013

AbstractAn unusual NaH‐mediated 1,5‐thia‐Fries rearrangement providing the title compounds is presented.
ChemInform Abstract: N‐Heterocyclic Carbene‐palladium(II)‐1‐methylimidazole Complex Catalyzed α‐Arylation of Oxindoles with Aryl Chlorides and Aerobic Oxidation of the Products in a One‐Pot Procedure.
Authors: Xiao Zheng‐Kang , Yin Hui‐Ying , Shao Li‐Xiong 
Published: July 2013

AbstractThe title reaction illustrates the first Pd‐catalyzed, phosphine‐free α‐arylation of oxindoles.
ChemInform Abstract: Palladium‐ and Copper‐Catalyzed Stereocontrolled Direct C—H Fluoroalkenylation of Heteroarenes Using gem‐Bromofluoroalkenes.
Authors: Schneider Cedric , Masi Daniela , Couve‐Bonnaire Samuel , Pannecoucke Xavier , Hoarau Christophe 
Published: July 2013

AbstractThe coupling of (E)‐bromofluoroalkenes with various azoles offers a stereocontrolled approach to trisubstituted monofluoroalkene derivatives.
ChemInform Abstract: Study on the Cyclization Methods of 3‐[1‐(Phenyl‐hydrazono)ethyl]‐chromen‐2‐ones.
Authors: Yang Guo‐Yu , Wang Cai‐Xia , Fan Su‐Fang , Zhao Long‐Jie , Wang Dan , Xu Cui‐Lian 
Published: July 2013

AbstractThree methods for the intramolecular cyclization of (I) are described and compared.
ChemInform Abstract: Synthesis and Cytotoxicity Evaluation of Highly Functionalized Pyranochromenes and Pyranopyrans.
Authors: Emmadi Narender Reddy , Atmakur Krishnaiah , Chityal Ganesh Kumar , Pombala Sujitha , Nanubolu Jagadeesh Babu 
Published: July 2013

AbstractHitherto unreported fluorinated pyranochromene (IV) and pyranopyran derivatives (VI) are synthesized via simple multicomponent reactions and evaluated for their cytotoxicity against a panel of human tumor cell lines.
ChemInform Abstract: Arylation, Alkenylation, and Alkylation of 2‐Halopyridine N‐Oxides with Grignard Reagents: A Solution to the Problem of C2/C6 Regioselective Functionalization of Pyridine Derivatives.
Authors: Zhang Song , Liao Lian‐Yan , Zhang Fang , Duan Xin‐Fang 
Published: July 2013

AbstractThe new method presented here works efficiently with various halopyridine N‐oxides and Grignard reagents tolerating a wide range of functional groups.
ChemInform Abstract: Synthesis of New Pyrazolo[1,5‐a]pyrimidines by Reaction of β,γ‐Unsaturated γ‐Alkoxy‐α‐keto Esters with N‐Unsubstituted 5‐Aminopyrazoles.
Authors: Stepaniuk Oleksandr O. , Matviienko Vitalii O. , Kondratov Ivan S. , Vitruk Igor V. , Tolmachev Andrei O. 
Published: July 2013

AbstractThe uncatalyzed title reaction produces various derivatives of the title heterocycle in good yields.
ChemInform Abstract: One‐Pot and Solvent‐Free Synthesis of 1,4‐Dihydropyridines and 3,4‐Dihydropyrimidine‐2‐ones Using New Synthetic Recyclable Catalyst via Biginelli and Hantzsch Reactions.
Authors: Shockravi Abbas , Kamali Mahmood , Sharifi Negar , Nategholeslam Mahdieh , Moghanlo Somayeh Pahlavan 
Published: July 2013

AbstractThe highly efficient cobalt complex catalyst is easily prepared and reusable at least five times without any significant loss of activity.
ChemInform Abstract: New Monoterpene Glycosides from Paeonia suffruticosa Andrews and Their Inhibition on NO Production in LPS‐Induced RAW 264.7 Cells.
Authors: Ding Liqin , Zhao Feng , Chen Lixia , Jiang Zhihu , Liu Yue , Li Zhuomin , Qiu Feng , Yao Xinsheng 
Published: July 2013

AbstractNine new monoterpene glycosides are isolated along with 18 known compounds from Paeonia suffruticosa Andrews.
ChemInform Abstract: Asymmetric Intermolecular Conjugate Addition of Amino Acid Derivatives via Memory of Chirality: Total Synthesis of Manzacidin A.
Authors: Yoshimura Tomoyuki , Kinoshita Tomohiko , Yoshioka Hiroyasu , Kawabata Takeo 
Published: July 2013

AbstractAsymmetric intermolecular conjugate addition of various α‐amino acid derivatives with (II) via memory of chirality is reported.
ChemInform Abstract: A Mild Multistep Conversion of N‐Protected α‐Amino Acids into N‐Protected β3‐Amino Acids Utilizing the Nef Reaction.
Authors: Sleebs Brad E. , Nguyen Nghi H. , Hughes Andrew B. 
Published: July 2013

Abstractα‐Amino acids (I) and (VII) are converted into chiral γ‐amino nitroalkanes of type (V) in a three‐step sequence.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling Reaction of Thioglycosides with (Hetero)aryl Halides.
Authors: Brachet Etienne , Brion Jean‐Daniel , Messaoudi Samir , Alami Mouad 
Published: July 2013

AbstractThioglycosides are used for the first time as effective nucleophiles for Buchwald—Hartwig cross‐coupling reactions using functionalized aryl halides (II).
Distributed model predictive control with asynchronous controller evaluations
Authors: Liu Su , Zhang Jing , Liu Jinfeng , Feng Yiping , Rong Gang 
Published: July 2013

AbstractIn this work, we focus on the reduction of network communication burden of cooperative distributed model predictive control (DMPC) of a class of nonlinear processes. Specifically, we propose a cooperative DMPC design in which the evaluations of the distributed controllers are triggered by the difference between the subsystem state measurements and the estimates of them. The individual model predictive controllers in this DMPC are designed via Lyapunov techniques. Under the assumption that state measurements of the subsystems are available, sufficient conditions for the closed‐loop stability are derived. The proposed DMPC is applied to a reactor–separator chemical process example and is compared with a cooperative DMPC in which distributed controllers are evaluated every sampling time extensively. The results demonstrate the applicability and effectiveness of the proposed approach.
SaC‐FRAPP: a scalable and cost‐effective framework for privacy preservation over big data on cloud
Authors: Zhang Xuyun , Liu Chang , Nepal Surya , Yang Chi , Dou Wanchun , Chen Jinjun 
Published: July 2013

SUMMARYBig data and cloud computing are two disruptive trends nowadays, provisioning numerous opportunities to the current information technology industry and research communities while posing significant challenges on them as well. Cloud computing provides powerful and economical infrastructural resources for cloud users to handle ever increasing data sets in big data applications. However, processing or sharing privacy‐sensitive data sets on cloud probably engenders severe privacy concerns because of multi‐tenancy. Data encryption and anonymization are two widely‐adopted ways to combat privacy breach. However, encryption is not suitable for data that are processed and shared frequently, and anonymizing big data and manage numerous anonymized data sets are still challenges for traditional anonymization approaches. As such, we propose a scalable and cost‐effective framework for privacy preservation over big data on cloud in this paper. The key idea of the framework is that it leverages cloud‐based MapReduce to conduct data anonymization and manage anonymous data sets, before releasing data to others. The framework provides a holistic conceptual foundation for privacy preservation over big data. Further, a corresponding proof‐of‐concept prototype system is implemented. Empirical evaluations demonstrate that scalable and cost‐effective framework for privacy preservation can anonymize large‐scale data sets and mange anonymous data sets in a highly flexible, scalable, efficient, and cost‐effective fashion. Copyright © 2013 John Wiley & Sons, Ltd.
Synthesis, Photophysics and Nonlinear Optical Properties of Stilbenoid Pyrimidine‐Based Dyes Bearing Methylenepyran Donor Groups
Authors: Achelle Sylvain , Malval Jean‐Pierre , Aloïse Stéphane , Barsella Alberto , Spangenberg Arnaud , Mager Loic , Akdas‐Kilig Huriye , Fillaut Jean‐Luc , Caro Bertrand , Robin‐le Guen Françoise 
Published: July 2013

AbstractThe nonlinear properties and the photophysical behavior of two π‐conjugated chromophores that incorporate an electron‐deficient pyrimidine core (A) and γ‐methylenepyrans as terminal donor (D) groups have been thoroughly investigated. Both dipolar and quadrupolar branching strategies are explored and rationalized on the basis of the Frenkel exciton model. Even though a cooperative effect is clearly observed if the dimensionality is increased, the nonlinear optical (NLO) response of this series is moderate if one considers the nature of the D/A couple and the size of the chromophores (as measured by the number of π electrons). This effect was attributed to a disruption in the electronic conjugation within the dyes’ scaffold for which the geometry deviates from planarity owing to a noticeable twisting of the pyranylidene end‐groups. This latter structural parameter also has a strong influence on the excited‐state dynamics, which leads to a very efficient fluorescence quenching.