bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation and application of American College of Radiology Thyroid Imaging Reporting and Data System for improved malignancy detection in paediatric thyroid nodules
Authors: Ortega Carlos A. , Gallant Jean‐Nicolas , Kilic Irem , Patel Siddharth , Chen Sheau‐Chiann , Wood C. Burton , Adams Ryan , Azer Fadi , Wang Huiying , Liang Jiancong , Duffus Sara H. , Belcher Ryan H. , Andreotti Rochelle F. , Krishnasarma Rekha , Lim‐Dunham Jennifer E. , Barkan Güliz A. , Ye Fei , Weiss Vivian L. 
Published: July 2024

AbstractObjectiveThe American College of Radiology Thyroid Imaging Reporting and Data System (TI‐RADS) is a widely used method for the management of adult thyroid nodules. However, its use in paediatric patients is controversial because adult fine needle aspiration biopsy (FNAB) recommendations may lead to delayed diagnoses of cancer in children. The objectives of this study were to evaluate the performance of TI‐RADS in paediatric thyroid nodules and to tailor FNAB recommendations for children.MethodsConsecutive surgically resected paediatric thyroid nodules from two tertiary care centres between 2003 and 2021 were reviewed. Ultrasounds were blindly scored by radiologists according to TI‐RADS. Management recommendations based on TI‐RADS were evaluated. Various modelling methodologies were used to determine the optimal cutoff for FNAB in children.ResultsOf the 96 patients, 79 (82%) were female and the median age at surgery was 16.1 years. Fifty (52%) nodules were malignant on surgical pathology. The area under the receiver operating characteristic curve of TI‐RADS for predicting malignancy was 0.78. Adult TI‐RADS recommendations would have resulted in 4% of cancerous nodules being lost to follow‐up. Modifications to TI‐RADS (FNAB of all TR3 nodules ≥1.5 cm, FNAB of TR4 and TR5 nodules ≥0.5 cm, surveillance of nodules ≥1 cm, consider surgery for nodules >4 cm) reduced this missed malignancy rate to 0%.ConclusionsTI‐RADS can risk‐stratify paediatric thyroid nodules. However, the system requires modifications to reduce the missed malignancy rate in paediatric thyroid nodules. Our data suggest that lower size thresholds for FNAB are warranted in children.
Severe brain injury and trends of gestational‐age‐related neurodevelopmental outcomes in infants born very preterm: A population cohort study
Authors: Wang Lan‐Wan , Chu Chi‐Hsiang , Lin Yung‐Chieh , Huang Chao‐Ching 
Published: July 2024

AbstractAimTo investigate the impact of severe neonatal brain injury (SNBI) on gestational age‐related trends in neurodevelopmental impairment (NDI) outcome in infants born very preterm.MethodA population‐based cohort study recruited 1091 infants born at a gestational age of less than 31 weeks between 2011 and 2020. The trends in neonatal morbidities, mortality, and 24‐month NDI severity (no/mild, moderate, severe) by epoch (2011–2015, 2016–2020) and gestational age (22–25 weeks, 26–28 weeks, 29–30 weeks) were determined in infants with and without SNBI inclusion.ResultsThere was increased antenatal steroid use and higher maternal education and socioeconomic status over time. The rates of neonatal morbidities and mortality had no temporal changes. Among 825 infants with follow‐up, those in the 22 to 25 weeks gestational age group had declining trends in cerebral palsy and severe cognitive impairment, with decreased rates of severe NDI from 19% to 8% across epochs, particularly in those without SNBI (from 16% to 2%). Relative to its occurrence in epoch 2011 to 2015, risk of severe NDI was significantly reduced in epoch 2016 to 2020 (adjusted relative risk 0.39, 95% confidence interval 0.16–0.96) for infants born at 22 to 25 weeks gestational age, and the risk dropped even lower in these infants without SNBI (0.12, 0.02–0.84).InterpretationInfants born at 22 to 25 weeks gestational age had decreased rates of severe NDI in the decade between 2011 and 2020, particularly those without SNBI. The improvement might be attributed to better perinatal/neonatal and after‐discharge care.
MAGEL2 (patho‐)physiology and Schaaf–Yang syndrome
Authors: Schubert Tim , Schaaf Christian P. 
Published: July 2024

AbstractSchaaf–Yang syndrome (SYS) is a complex neurodevelopmental disorder characterized by autism spectrum disorder, joint contractures, and profound hypothalamic dysfunction. SYS is caused by variants in MAGEL2, a gene within the Prader–Willi syndrome (PWS) locus on chromosome 15. In this review, we consolidate decades of research on MAGEL2 to elucidate its physiological functions. Moreover, we synthesize current knowledge on SYS, suggesting that while MAGEL2 loss‐of‐function seems to underlie several SYS and PWS phenotypes, additional pathomechanisms probably contribute to the distinct and severe phenotype observed in SYS. In addition, we highlight recent therapeutic advances and identify promising avenues for future investigation.
Mechanisms underlying the development of eating disorders and disordered eating in adolescent females with type 1 diabetes
Authors: Abild Caroline Bruun , Vestergaard Esben Thyssen , Bruun Jens Meldgaard , Kristensen Kurt , Støving Rene Klinkby , Clausen Loa 
Published: July 2024

AbstractObjectivePeople with Type 1 diabetes (T1D) face an increased risk of eating disorders/disordered eating (ED/DE), with adolescents being particularly vulnerable. Empirical knowledge on the mechanisms underlying development of ED/DE in T1D is crucial for evolving prevention strategies.Research Design and MethodsFourteen semi‐structured interviews with adolescent females with T1D and ED/DE between 14 and 18 years were conducted and analyzed using reflexive thematic analysis.ResultsAnalyses identified four main themes; ‘Interconnected afflictions’, ‘Judgment’, ‘Feeling Different’, and ‘Chaos & Control’, These themes explore the interconnectedness of T1D and ED/DE, with shame and guilt emerging as common underlying mechanism. The development of a biopsychosocial model was based on the integration of these data with existing models.ConclusionsThe study extends previous developmental pathways of ED/DE in adolescents with T1D. We propose a biopsychosocial model that incorporates various factors: predisposing factors such as parental management of T1D and weight gain during adolescence; precipitating factors including comments on weight, frequency of weighing, perceptions of surveillance; the perpetuating bilateral influence of ED/DE and T1D and finally highlighting the protective mechanisms of disease acceptance encompassing parental handling of diagnosis and the contribution of healthcare professionals (HCP's) role in psychoeducation. The present study highlight the vulnerability of adolescence in the presence of T1D, particularly concerning issues related to eating, weight, and body. It offers clinically relevant insights, with the aim to improve communication and management strategies for this very specific group.
Caring for minorities: The Flexible Decision Rule
Authors: Frey Bruno S. , Briviba Andre 
Published: July 2024

AbstractSimple majority rule disregards the interests of the losing minority; their vote does not affect the outcome. When vote outcomes are narrow, close to 50% of voters, the concerns of a significant part of the voters are disregarded. This increases polarization in the population and endangers democracy. This paper proposes a new procedure for political decisions by referendums. The Flexible Decision Rule formally takes into account the percentage of voters accepting or rejecting a proposal. The higher the share y of voters accepting it, the more strongly the proposal is to be put into reality; the lower y is, the less strongly the proposal is to be put into reality. This procedure explicitly considers the concerns of both the supporters and the opponents thus raising the fairness of the vote procedure. In contrast to majority voting, each vote marginalizes the outcome and therefore raises the incentive to participate in the vote increase.
Unraveling female mate choice in Schizocosa mccooki: The interplay of male mass and vibratory courtship
Authors: Yan Lin , Sabaria Athena , Elias Damian O. , Rosenthal Malcolm F. 
Published: July 2024

AbstractSexual selection is an important evolutionary force and despite extensive research, understanding mate choice on naturally occurring trait variation remains an intriguing area of study. The correlation between mass, a trait associated with courter viability and common target for mate choice, and signals is particularly noteworthy. This study focuses on Schizocosa mccooki, the largest member of a wolf spider genus renowned for its diverse complex male courtship. Our objective was to understand the relationship of male mass and other courtship signals on female choice within this species. We conducted lab experiments involving random pairings of field caught males and females, recording vibratory courtship and its outcomes. Our findings revealed that S. mccooki courtship consisted of vibratory signals with two major components, thumps and raps. Male mass, overall courtship vigor, and thump duration were found to predict mating success. Interestingly, we found no correlation between temporal traits and mass suggesting independent information and an absence of trade‐offs between mass, courtship vigor, and signal component rates/durations. Instead, we found that heavier males tend to produce thumps with lower frequencies. The finding that male mass predicts mating success contrasts with patterns observed in other species in this well‐studied genus. By uncovering the mate choice patterns of S. mccooki, this study underscores the importance of comparative studies to understand the ways in which sexual selection drives diversification, even among closely related taxa.
Deepening our understanding of the environmental influences on the reproductive dynamics of the main fishery stock of Argentine hake, Merluccius hubbsi, in the southwestern Atlantic Ocean
Authors: Elisio Mariano , Diaz Marina V. , Leonarduzzi Ezequiel , Rodrigues Karina A. , Burla Juan M. , Macchi Gustavo J. 
Published: July 2024

AbstractThis study analyzed the inter‐annual variability in the reproductive dynamics of the Argentine hake from Patagonian waters during the last 20 years concerning the environmental conditions and the nutritional status of females. Macroscopic and histological information on gonadal maturity, female condition factor (K), and oceanographic data at different sampling sites throughout the studied region were obtained from research surveys carried out during the main spawning season of this species. Four stages, according to the maturity ovarian phases composition, were assigned annually at each sampling site to assess reproductive dynamics: vitellogenesis, ovulation, regression, and resting. The spatial pattern of inter‐annual variability in reproductive dynamics was described, and the influence of temperature and female condition on the probability of ovulation and regression was assessed using generalized linear models. The area with the lowest inter‐annual variability in the hake reproductive dynamics was observed between 43 and 45°S (50 to 80 m depth) in relation to ovulation events. The vitellogenesis stage was more frequently found adjacent to the reproductive area, whereas the regression was mainly observed in deeper waters. Both bottom and surface temperatures explained the ovulation and regression stages, showing a positive and negative relationship, respectively. Lower values of the K factor, associated with low food availability, were further linked to the occurrence of regression. Finally, it is worth noting that the relationship observed between the ovulation/spawning dynamics of Argentine hake and water temperature suggests that the reproductive success of this species could be affected in the future scenario of climate change.
Evaluation of effects of heat released from SOC decomposition on soil carbon stock and temperature
Authors: Huang Ye , Huang Lin , Qiu Chunjing , Ciais Philippe 
Published: July 2024

AbstractHeat released from soil organic carbon (SOC) decomposition (referred to as microbial heat hereafter) could alter the soil's thermal and hydrological conditions, subsequently modulate SOC decomposition and its feedback with climate. While understanding this feedback is crucial for shaping policy to achieve specific climate goal, it has not been comprehensively assessed. This study employs the ORCHIDEE‐MICT model to investigate the effects of microbial heat, referred to as heating effect, focusing on their impacts on SOC accumulation, soil temperature and net primary productivity (NPP), as well as implication on land‐climate feedback under two CO2 emissions scenarios (RCP2.6 and RCP8.5). The findings reveal that the microbial heat decreases soil carbon stock, predominantly in upper layers, and elevates soil temperatures, especially in deeper layers. This results in a marginal reduction in global SOC stocks due to accelerated SOC decomposition. Altered seasonal cycles of SOC decomposition and soil temperature are simulated, with the most significant temperature increase per unit of microbial heat (0.31 K J−1) occurring at around 273.15 K (median value of all grid cells where air temperature is around 273.15 K). The heating effect leads to the earlier loss of permafrost area under RCP8.5 and hinders its restoration under RCP2.6 after peak warming. Although elevated soil temperature under climate warming aligns with expectation, the anticipated accelerated SOC decomposition and large amplifying feedback on climate warming were not observed, mainly because of reduced modeled initial SOC stock and limited NPP with heating effect. These underscores the multifaceted impacts of microbial heat. Comprehensive understanding of these effects would be vital for devising effective climate change mitigation strategies in a warming world.
Wettability of non‐metallic inclusions and its impact on bubble‐induced flotation kinetics
Authors: Falsetti Luís Otávio Z. , Delfos René , Charruault Florian , Luchini Bruno , Van Der Plas Dirk , Pandolfelli Victor C. 
Published: July 2024

AbstractCeramic refractory bubbling devices may be applied in the steel ladle to induce the flotation of non‐metallic inclusions to the slag phase. These inclusions have many origins along the steelmaking process and induce a detrimental effect on the mechanical properties of these metals. Therefore, the design of high‐performance ceramic plugs relies on understanding the fundamentals of non‐metallic inclusions captured by the gas bubbles. This study investigated the flotation dynamics of hydrophobic and hydrophilic hollow glass particles through experimentation using a water model and quantifying the particle concentration via light scattering. Both types of particles exhibited a comparable natural flotation removal rate, whereas a 40% increase for hydrophobic particles was observed when introducing 1.1 mm bubbles (at 25 NL/h) enhancing the efficiency from 43.1% to 65.2%. For hydrophilic particles, the efficiency increased from 59.1% to 86.2% when bubbles were injected into the system, whereas the removal rate decreased by 2.1‐fold. The consequence of the practice of inert gas purging to remove non‐metallic inclusions is also discussed.
Relations of personality factors and suitability ratings to Swedish military pilot education completion
Authors: Sehlström Malcolm , Ljungberg Jessica K. , Nyström Markus B. T. , Claeson Anna‐Sara 
Published: July 2024

AbstractImproved understanding of what it takes to be a pilot is an ongoing effort within aviation. We used an exploratory approach to examine whether there are personality‐related differences in who completes the Swedish military pilot education. Assessment records of 182 applicants, accepted to the education between the years of 2004 and 2020 were studied (Mean age 24, SD 4.2 96% men, 4% women). Discriminant analysis was used to explore which personality traits and suitability ratings might be related to education completion. Analysis included suitability assessments made by senior pilots and by a psychologist, a number of traits assessed by the same psychologist, as well as the Commander Trait Inventory (CTI). The resulting discriminant function was significant (Wilk's Lambda = 0.808, (20) = 32.817, p = .035) with a canonical correlation of 0.44. The model was able to classify 74.1% of sample cases correctly. The modeling suggests that senior pilot assessment and psychologist assessment both predict education completion. Also contributing were the traits energy, professional motivation, study forecast and leader potential.
Scar outcomes for conservatively managed children post burn injury: A retrospective study
Authors: Ball Stephanie , Wicks Stephanie , Thomas Rhianydd , Toose Claire , Gray Kelly , Pacey Verity 
Published: July 2024

AbstractHypertrophic scarring is a significant complication post burn injury, especially for delayed healing after 3 weeks. Burn injuries healing prior to 3 weeks also have the potential to develop hypertrophic scarring, even when prescribed prophylactic conservative scar interventions. A retrospective chart audit reviewed 326 burn patients treated at a paediatric tertiary hospital from 2014 to 2019 who sustained a partial thickness burn, healed >14 days and did not receive skin grafting. A scar was deemed hypertrophic if >1 mm in height. Early hypertrophic scar prevalence was defined as 3–6 months post burn, while persistent hypertrophic scarring was defined as 12–18 months post burn. Median days to wound closure was 18. The prevalence of early and persistent hypertrophic scarring was 56.1% and 16.3%, respectively. Seventeen (5.2%) children underwent medical interventions for scar modulation. Early signs of hypertrophic scarring were seen in just over half the patients presenting to burn therapy and despite scar intervention, persistent hypertrophic scarring was seen in 16.3%. At both time points, just over half of the children presenting healed between 14 and 21 days. Therefore, children healing prior to 21 days have potential to develop hypertrophic scarring.
Functionally multilayered Yb‐silicate EBCs fabricated using slurry spraying‐reactive sintering technique
Authors: Waghmare Gauri , Hastak Vikram , Gandhi Ashutosh S. 
Published: July 2024

AbstractFunctionally multilayered environmental barrier coatings (EBCs) with the desired layer sequence of Yb2O3/Yb2SiO5/Yb2Si2O7/SiO2/Si were obtained using an unconventional yet simple technique of reactive sintering. Yb2O3 slurry was sprayed on polycrystalline silicon (used as a bond coat for SiCf/SiC composites) and reactive sintered to generate graded layers that provide a combination of mitigated thermal expansion mismatch as well as silica activity. The Yb2O3‐terpineol slurry produced a uniform deposit of the Yb2O3 topcoat. Reactive sintering of exploratory coatings (t ∼ 10–20 µm) was carried out in air by varying the temperature (1100–1400°C) and time (2–24 h). X‐ray diffraction and scanning electron microscopy‐energy‐dispersive spectroscopy technique confirmed the in situ formation of X2‐Yb2SiO5 and β‐Yb2Si2O7. Rietveld refinement was performed to know the volume fractions of the respective phases. The set of process parameters identified from the preliminary work was employed to fabricate EBCs with thickness ∼ 250 µm. The X2‐Yb2SiO5 and β‐Yb2Si2O7 phases formed next to the Si/SiO2 interface as two separate layers. Post‐sintering heat treatments in air at 1300, 1350, and 1400°C for 3–50 h elucidated the growth characteristics of the oxide layers to be a function of both temperature and time. The theoretical considerations of diffusional reactive phase formation of the EBC multilayer growth rates are discussed.
Barriers and facilitators influencing implementation of care technology for people with intellectual disabilities: A cross‐sectional study among care professionals
Authors: Siebelink Nienke M. , Gaasterland Annemarije , Gielissen Marieke , van der Weegen Sanne , Boon Brigitte , van der Poel Agnes 
Published: July 2024

AbstractBackgroundImplementation issues often hinder reaching the potential of care technology to improve daily lives of people with intellectual disabilities. We investigated barriers to and facilitators of implementing different technology modalities (app/social robot/sensor/domotics) in long‐term care.MethodCare professionals (N = 83) from 12 Dutch disability care organisations completed a customised measurement instrument for determinants of innovations (MIDI) questionnaire.ResultsOut of 27 determinants, 20 were identified as facilitators and 16 as barriers. We highlight common barriers: few colleagues who work with the technology; no (awareness of) formal ratification of technology use; no arrangements regarding turnover of staff using the technology; unsettling organisational changes; technological defects and limited IT preconditions.ConclusionsThe results, which could be combined and compared across study sites, provide insight into which implementation determinants were already well addressed, and where there is ground to gain when implementing care technology in disability care organisations.
Association between inflammatory biomarkers and hypertension among sedentary adults in US: NHANES 2009–2018
Authors: Sha Shuo , Bu Xing‐Peng , Wang Ai‐Wen , Chen Huan‐Zhen 
Published: July 2024

AbstractOur study focuses on the relationship between inflammatory biomarkers and hypertension among sedentary adults in the United States, using data from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018. We categorized 24,614 participants into two groups based on their daily sedentary time: 9607 individuals in the sedentary group (≥7 h) and 15,007 in the non‐sedentary group (<7 h). We found that the sedentary group had a significantly higher prevalence of hypertension than the non‐sedentary group. Using weighted multiple logistic regression and smoothing curves, we assessed the correlation between inflammatory biomarkers and hypertension among the sedentary adults. The odds ratios for hypertension were 1.92 for the monocyte to high‐density lipoprotein ratio (MHR), 1.15 for the systemic inflammation response index (SIRI), and 1.19 for the natural logarithm of the systemic immune‐inflammation index (lnSII), all showing nonlinear associations. Furthermore, a significant positive correlation was found between sedentary time and inflammatory biomarkers (MHR, SIRI, and lnSII). Our findings suggest that prolonged sedentary behavior in the US significantly increases hypertension risk, likely due to marked increases in inflammation markers.
Dynamic pathology and pathogen distribution of the yeast Metschnikowia bicuspidata in the Chinese mitten crab (Eriocheir sinensis)
Authors: Shi Xinran , Sun Na , Liu Jiannan , Pu Senting , Chen Zhouling , Sheng Dong , Hao Kexin , Li Xiaodong , Ye Shigen 
Published: July 2024

AbstractIn this study, the “milky disease” model of Eriocheir sinhensis was constructed via intramuscular injection with the pathogenic yeast Metschnikowia bicuspidata. The dynamic pathological changes of E. sinensis after injection were elucidated with two staining methods (haemotoxylin‐eosin and alcian blue periodic acid‐Schiff) and fluorescence in situ hybridization technology. Anatomical observation revealed three stages of the “milky disease”: no clinical signs (1–4 days after infection), the appearance of signs of disease (5–7 days), and significant liquefaction (10 days). Histological observation also revealed three stages of the disease: yeast diffusion (1–2 days after infection), yeast slow development (3–4 days), and yeast rapid proliferation (5 days). And FISH technique was suitable for the early detection of infection with M. bicuspidata in E. sinensis. We found that M. bicuspidata spread to the whole body of the crab through the haemolymph and developed into fungal septicaemia. These results elucidate the systemic pathological characteristics of “milky disease” in E. sinensis and suggest the pathogenic mechanism of M. bicuspidata.