bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation between instrumental texture and colour quality attributes with sensory analysis of selected cheeses as affected by fat contents
Authors: Półtorak A. , Wyrwisz J. , Moczkowska M. , Marcinkowska‐Lesiak M. , Stelmasiak A. , Ulanicka U. , Zalewska M. , Wierzbicka A. , Sun Da‐Wen 
Published: December 2014

SummaryThis study evaluated several physical and sensory parameters of different types of cheese available in the Polish market. The measurements of textural properties were conducted in an Instron universal testing machine, while the colour properties of cheeses were measured using a Minolta chromameter. The chemical composition was determined by means of the near‐infrared spectroscopy (NIRs). Moreover, a trained sensory panel was invited to assess the cheese texture‐related properties. Generally, cheeses with reduced fat content were characterised by higher hardness, adhesiveness, cohesiveness and elasticity. Texture‐related parameters of cheese with canola oil were comparable to that of most of full‐fat cheeses. The correlation analysis between physical and sensory attributes related to cheese textural properties indicated the potential applications of TPA, shear and penetration tests (r = 0.766, r = 0.75 and r = 0.765, respectively) for the evaluation of sensory properties related to the hardness. Meanwhile, the elasticity of cheese obtained from sensory evaluation was strongly correlated with the elasticity determined from the shear test (r = 0.722) and moderately correlated with the elasticity from penetration test (r = 0.588), indicating a need to refine the method of penetration test. In addition, cheeses exhibited higher meltability during convection heating at 230 °C than microwave heating. The values of meltability for cheese with reduced fat content were lower than those of full‐fat cheese.
Potentially probiotic acetic acid bacteria isolation and identification from traditional dairies microbiota
Authors: Haghshenas Babak , Nami Yousef , Abdullah Norhafizah , Radiah Dayang , Rosli Rozita , Barzegari Abolfazl , Yari Khosroushahi Ahmad 
Published: December 2014

SummaryAmong probiotics, acetic acid bacteria (AAB) can be used as preservative agents because of their high fermentation and acidification activities. This study aimed to isolate, identify and biologically characterise Acetobacter strains from traditional Iranian dairy products. Acetobacter strains were identified by catalase assay, Gram staining, and combined repetitive sequence‐based PCR [(GTG)5‐PCR fingerprints] and 16S rDNA gene sequencing. We identified eight strains belonging to four species, including Acetobacter aceti, Acetobacter indonesiensis, Acetobacter cibinongensis and Acetobacter syzygii. The molecular techniques could be used as an effective and rapid alternative tool to identify and characterise dairy‐associated AAB. Primary probiotic assessments, including low pH and high bile salt tolerance tests, antagonistic activity test against pathogens, and antibiotic susceptibility confirmed the probiotic properties of these AAB, particularly A. cibinongensis 34L strain, which was isolated from curd. Therefore, this strain can be introduced as novel candidate probiotics that could be used in the food industry.
Application of cold oxygen plasma for the reduction of Cladosporium cladosporioides and Penicillium citrinum on the surface of dried filefish (Stephanolepis cirrhifer) fillets
Authors: Park Shin Young , Ha Sang‐Do 
Published: December 2014

SummaryThis study was conducted to investigate the effects of cold oxygen plasma (COP) on the reductions of Penicillium citrinum and Cladosporium cladosporioides on the surface of dried filefish fillets (Stephanolepis cirrhifer). The counts were significantly (P < 0.05) reduced with the increase in the treatment time (3–20 min) of COP on the fillets. However, no significant (P > 0.05) differences were observed in the counts between 3 and 5 min of COP. The average decrease in the counts of C. cladosporioides and P. citrinum caused by 3–20 min of COP was 0.91 and 1.04 log10 CFU g−1, respectively. A reduction of >1‐log10 CFU g−1 was observed on the fillets treated with COP for >10 min. Decimal reduction time (dR) by Weibull model was 9.32 and 7.42 min of COP for C. cladosporioides and P. citrinum, respectively. The fillets exposed to 20 min of COP displayed increased thiobarbituric acid reactive substance (TBARS) and decreased overall sensory acceptance. However, the fillets treated with 10 min of COP received satisfactory TBARS and consumer acceptance. Therefore, a 10‐min COP could be effective in reducing >90% and inactivating of the mould without causing any deleterious changes to the physicochemical and sensory qualities of the fillet.
Protocol for Cilostazol Stroke Prevention Study for Antiplatelet Combination (CSPS.com): A Randomized, Open-Label, Parallel-Group Trial
Authors: Toyoda Kazunori , Uchiyama Shinichiro , Hoshino Haruhiko , Kimura Kazumi , Origasa Hideki , Naritomi Hiroaki , Minematsu Kazuo , Yamaguchi Takenori ,   for the CSPS.com Study Investigators
Published: December 2014

Rationale and aims Monotherapy with antiplatelet agents is only modestly effective in secondary prevention of ischemic stroke (IS), particularly in patients with multiple risk factors such as cervicocephalic arterial stenosis, diabetes, and hypertension. While dual antiplatelet therapy (DAPT) with aspirin and clopidogrel reduced IS recurrence, particularly in the early stages after IS, it increased the risk of bleeding. Compared with aspirin, cilostazol prevented IS recurrence without increasing the incidence of serious bleeds. In patients with intracranial arterial stenosis, no significant increase in bleeding events was observed for DAPT with cilostazol and aspirin, compared to that for aspirin monotherapy. DAPT involving cilostazol may therefore be safer than conventional DAPT. These findings prompted us to conduct the Cilostazol Stroke Prevention Study for Antiplatelet Combination ( CSPS.com ; ClinicalTrials.gov identifier: NCT01995370) to evaluate the safety and efficacy of DAPT involving cilostazol for secondary IS prevention, in comparison with that of antiplatelet monotherapy. Design The CSPS.com is a multicenter, randomized, open-label, parallel-group trial. A total of 4000 high-risk patients with noncardioembolic IS will be randomized 8–180 days after onset to receive aspirin or clopidogrel monotherapy, or DAPT with cilostazol and aspirin or clopidogrel for at least one-year. Study outcomes The primary outcome is IS recurrence. Secondary outcomes are composite occurrences of any stroke, death from any cause, myocardial infarction, vascular death, and other vascular events. Discussion The CSPS.com is expected to provide evidence indicating whether secondary IS prevention in high-risk patients can be improved by using DAPT involving cilostazol.
Outcomes after Stroke Thrombolysis According to Prior Antiplatelet Use
Authors: Meseguer Elena , Labreuche Julien , Guidoux Celine , Lavallée Philippa C. , Cabrejo Lucie , Sirimarco Gaia , Valcarcel Jaime G. , Klein Isabelle F. , Amarenco Pierre , Mazighi Mikael 
Published: December 2014

Background Thirty percent of ischemic stroke (IS) patients suffering from acute stroke are under antiplatelet therapy. Aims We evaluated whether prior antiplatelet use before intravenous (IV), intra-arterial (IA) or combined IV/IA therapy may be associated with worse outcomes and an increased intracerebral hemorrhage (ICH) risk after reperfusion therapies. Methods We analyzed data from our patient registry ( n = 874) and conducted a systematic review of previous observational studies. The primary outcome was the percentage of patients who developed symptomatic ICH (sICH), defined in our registry per ECASS-II definition. Results We identified 43 previous reports that evaluated the impact of prior antiplatelet use on outcomes after reperfusion therapy in AIS patients. Prior antiplatelet use was found in 35% of AIS patients, eligible for reperfusion therapies and was associated with a worse vascular profile. In an unadjusted meta-analysis that included our registry data, prior antiplatelet use was associated with more sICH per ECASS-II definition (OR, 1·78 (95% CI, 1·48–2·13), and less favorable outcome (OR, 0·86; 95% CI, 0·77–0·98). However, in multivariate analyses conducted in our registry showed that prior antiplatelet use was not associated with worse outcome ( P > 0·23); and in the systematic review, only 3 studies reported a slight, but significant adjusted increase in sICH risk, of whom one had conflicting results according to sICH definition. Conclusions These results suggest no significant detrimental effect of prior antiplatelet use in AIS patients treated by IV, IA or combined IV/IA therapy. Further studies are needed to assess the specific impact of different and cumulative antiplatelet agents.
Insect midgut carboxypeptidases with emphasis on S10 hemipteran and M14 lepidopteran carboxypeptidases
Authors: Ferreira C. , Rebola K. G. O. , Cardoso C. , Bragatto I. , Ribeiro A. F. , Terra W. R. 
Published: December 2014

AbstractWe compared the whole complement of midgut carboxypeptidases from 10 insects pertaining to five orders based on transcriptomes obtained by deep sequencing and biochemical data. Most of the carboxypeptidases were metallocarboxypeptidases from family M14, with carboxypeptidase A (CPA) predominating over carboxypeptidase B (CPB). They were found in all of the insects studied except for the hemipterans and a bruchid beetle. M14 carboxypeptidases were expressed only in the midgut of Spodoptera frugiperda (Lepidoptera). The most expressed CPA from this insect (SfCPA) was cloned, sequenced and expressed as a recombinant enzyme. This enzyme was used to generate antibodies used to demonstrate that SfCPA is secreted by an exocytic route. Serine carboxypeptidases from family S10 were found in all of the insects studied here. In S. frugiperda, they are expressed in all tissues besides the midgut, in accordance with their presumed lysosomal role. In the hemipteran Dysdercus peruvianus, S10 carboxypeptidases are expressed only in midgut, suggesting that they are digestive enzymes. This was confirmed by enzyme assays of midgut contents. Furthermore, the substrate specificity of D. peruvianus S10 carboxypeptidases are predicted to be one CPC (preferring hydrophobic residues) and one CPD (preferring basic residues), thus able to hydrolyse the peptides formed by their digestive cathepsin D and cathepsin L, respectively. The role of S10 carboxypeptidases in bruchid beetles are suggested to be the same as in hemipterans.
Combined treatment with chlorhexidine and 0·9% saline in a newborn infant with an infected surgical wound
Authors: Tekgündüz Kadir Şerafettin , Kepenekli Eda , Demirelli Yaşar , Caner İbrahim , Kara Mustafa 
Published: December 2014

AbstractNewborns are more susceptible to infection; this makes proper wound care extremely important in them. Unfortunately, in spite of successful surgery, patients can die as a result of wound area infections. Herein, we report a case in which a combined therapy of chlorhexidine (a disinfectant) and saline (a cleansing agent used in wound care) was used effectively to treat the wound in a newborn infant with an antibiotic‐resistant, Gram‐negative, bacteria‐related surgical site infection.
Aetiology, comorbidities and cofactors of chronic leg ulcers: retrospective evaluation of 1 000 patients from 10 specialised dermatological wound care centers in Germany
Authors: Jockenhöfer Finja , Gollnick Harald , Herberger Katharina , Isbary Georg , Renner Regina , Stücker Markus , Valesky Eva , Wollina Uwe , Weichenthal Michael , Karrer Sigrid , Kuepper Bernhard , Roesch Alexander , Dissemond Joachim 
Published: December 2014

AbstractNumerous comorbidities and cofactors have been known to influence wound healing processes. In this multicentre study, clinical data of 1 000 patients with chronic leg ulcers from ten specialised dermatological wound care centers were analysed. The patient cohort comprised 567 females and 433 males with an average age of 69·9 years. The wounds persisted on average for 40·8 months and had a mean size of 43·7 cm2. Venous leg ulcers represented the most common entity accounting for 51·3% of all chronic wounds, followed by mixed‐type ulcers in 12·9% and arterial ulcerations in 11·0% of the patients. Vasculitis was diagnosed in 4·5%, trauma in 3·2%, pyoderma gangrenosum in 2·8%, lymphoedema in 1·7%, neoplasia in 1·0% and delayed post‐surgical wound healing in 0·6% of the included patients. In total, 70·5% of patients suffered from arterial hypertension, 45·2% were obese, 27·2% had non‐insulin dependent diabetes, and 24·4% dyslipidaemia. Altogether 18·4% suffered from metabolic syndrome. Cofactors and comorbidities of patients with chronic leg ulcers have previously been studied but not in detail. Here, we were able to demonstrate the existence of several potentially relevant cofactors, comorbidities of their associations and geographical distributions, which should be routinely examined in patients with chronic leg ulcers and – if possible – treated.
Impact of Ba2+ on Structure and Piezoelectric Properties of PMN–PZN–PNN–PT Ceramics Near the Morphotropic Phase Boundary
Authors: Talanov Mikhail V. , Shilkina Lidiya A. , Verbenko Iliya A. , Reznichenko Larisa A. 
Published: December 2014

The effect of using Ba2+ to modify the structure and dielectric and piezoelectric properties of Pb(1−x)Bax(Mg1/3Nb2/3)m(Zn1/3Nb2/3)y(Ni1/3Nb2/3)nTizO3(x = 0–0.15) ceramics near the morphotropic phase boundary has been investigated. It is found that increasing the content of Ba2+ leads to a sequence of structural transformations from heterophase state (tetragonal and pseudocubic phases) to a cubic state via an intermediate pseudocubic phase. The evolution of the dielectric and piezoelectric properties (sequences of transformations: normal ferroelectric →relaxor ferroelectric → paraelectric) is shown. It is stated that ceramics with x = 0.025–0.050 possess the optimal combination of functional parameters for use in low‐frequency receivers and actuators. They are characterized by high values of small‐signal and large‐signal piezoelectric coefficients d33 of 621 pC/N and ~1500 m/V (at E = 5 kV/cm), respectively, and also by increased values of dielectric permittivity ε/ε0 and tunability coefficient (К = [(ε/ε0(E = 0) − ε/ε0(E≠0))/ε/ε0(E = 0)]·100%), equal to ~7000 and ~80%, respectively (at E = 20 kV/cm). It is shown that for the creation of high‐power piezoelectric transducers it is necessary to use ceramics with x = 0.125, which differs with high values of the mechanical quality factor Qm and ε/ε0 (1406 and 10 890, respectively).
Boater Perceptions of Environmental Issues Affecting Lakes in Northern Wisconsin
Authors: Beardmore Ben 
Published: December 2014

AbstractUnderstanding public perceptions of the importance of environmental issues is crucial for gauging support for management activities. I present a novel methodological approach to assess the importance boaters placed on 16 water issues in a lake‐rich region of northern Wisconsin. A latent class maximum difference conjoint model was used to examine the relationships between environmental concern and engagement with lake resources. Boaters were grouped to maximize observed heterogeneity in prioritizing issues of concern. Socio‐demographic characteristics, recreation specialization, place attachment, and attitudes concerning aquatic stewardship and invasive species management were then used to predict class membership. This modeling approach identified five groups whose perceptions of issues pertaining to lakes are influenced by their interactions with the lake environment. While anglers were most concerned about fishing quality, sightseers identified lakeshore development and loss of natural habitat. Groups also differed in their socio‐demographic and attitudinal characteristics. The priorities of each group were substantially different from those of the overall sample. Accounting for differences in stakeholders' environmental concerns may improve public involvement in water management initiatives by allowing managers to identify common concerns and prioritize important issues among multiple groups.
Seasonal and Regional Patterns in Performance for a Baltic Sea Drainage Basin Hydrologic Model
Authors: Lyon Steve W. , Meidani Roya , van der Velde Ype , Dahlke Helen E. , Swaney Dennis P. , Mörth Carl‐Magnus , Humborg Christoph 
Published: December 2014

AbstractThis study evaluates the ability of the Catchment SIMulation (CSIM) hydrologic model to describe seasonal and regional variations in river discharge over the entire Baltic Sea drainage basin (BSDB) based on 31 years of monthly simulation from 1970 through 2000. To date, the model has been successfully applied to simulate annual fluxes of water from the catchments draining into the Baltic Sea. Here, we consider spatiotemporal bias in the distribution of monthly modeling errors across the BSDB since it could potentially reduce the fidelity of predictions and negatively affect the design and implementation of land‐management strategies. Within the period considered, the CSIM model accurately reproduced the annual flows across the BSDB; however, it tended to underpredict the proportion of discharge during high‐flow periods (i.e., spring months) and overpredict during the summer low flow periods. While the general overpredictions during summer periods are spread across all the subbasins of the BSDB, the underprediction during spring periods is seen largely in the northern regions. By implementing a genetic algorithm calibration procedure and/or seasonal parameterization of subsurface water flows for a subset of the catchments modeled, we demonstrate that it is possible to improve the model performance albeit at the cost of increased parameterization and potential loss of parsimony.
Differential expression of basal microRNAs’ patterns in human dental pulp stem cells
Authors: Vasanthan Punitha , Govindasamy Vijayendran , Gnanasegaran Nareshwaran , Kunasekaran Wijenthiran , Musa Sabri , Abu Kasim Noor Hayaty 
Published: December 2014

AbstractMicroRNAs (miRNAs) are small non‐coding RNAs that regulate translation of mRNA into protein and play a crucial role for almost all biological activities. However, the identification of miRNAs from mesenchymal stem cells (MSCs), especially from dental pulp, is poorly understood. In this study, dental pulp stem cells (DPSCs) were characterized in terms of their proliferation and differentiation capacity. Furthermore, 104 known mature miRNAs were profiled by using real‐time PCR. Notably, we observed 19 up‐regulated miRNAs and 29 significantly down‐regulated miRNAs in DPSCs in comparison with bone marrow MSCs (BM‐MSCs). The 19 up‐regulated miRNAs were subjected to ingenuity analysis, which were composed into 25 functional networks. We have chosen top 2 functional networks, which comprised 10 miRNA (hsa‐miR‐516a‐3p, hsa‐miR‐125b‐1‐3p, hsa‐miR‐221‐5p, hsa‐miR‐7, hsa‐miR‐584‐5p, hsa‐miR‐190a, hsa‐miR‐106a‐5p, hsa‐mir‐376a‐5p, hsa‐mir‐377‐5p and hsa‐let‐7f‐2‐3p). Prediction of target mRNAs and associated biological pathways regulated by each of this miRNA was carried out. We paid special attention to hsa‐miR‐516a‐3p and hsa‐miR‐7‐5p as these miRNAs were highly expressed upon validation with qRT‐PCR analysis. We further proceeded with loss‐of‐function analysis with these miRNAs and we observed that hsa‐miR‐516a‐3p knockdown induced a significant increase in the expression of WNT5A. Likewise, the knockdown of hsa‐miR‐7‐5p increased the expression of EGFR. Nevertheless, further validation revealed the role of WNT5A as an indirect target of hsa‐miR‐516a‐3p. These results provide new insights into the dynamic role of miRNA expression in DPSCs. In conclusion, using miRNA signatures in human as a prediction tool will enable us to elucidate the biological processes occurring in DPSCs.
Does Banking Union Worsen theEU's Democratic Deficit? The Need for Greater Supervisory Data Transparency
Authors: Gandrud Christopher , Hallerberg Mark 
Published: December 2014

AbstractDoes banking union exacerbate the European Union's democratic deficit? Using Scharpf's ‘input’ and ‘output’ legitimacy concepts, it is argued in this article that its design does worsen the democratic deficit. There are good reasons to limit ‘input legitimacy’ for politically independent institutions. ‘Output legitimacy’ is then even more relevant. Transparency is a key part of ‘output legitimacy’. It enables actors to judge whether the regulator is acting in the public's interest and can improve their outputs. This article focuses on the banking data that the supervisors collect. Data available to the European public is evaluated and compared toAmerica's banking union. European practices are not comparable in terms of availability or detail. An original survey of relevant officials is conducted, which results in the finding that only 11 of 28 Member States release any information on the banks they supervise. BothEUand national supervisors should provide publicly available, timely and consistent individual bank data.
One Currency, One Price? Euro Changeover‐Related Inflation in Estonia
Authors: Meriküll Jaanika , Rõõm Tairi 
Published: December 2014

AbstractThis article investigates euro changeover‐related inflation using disaggregated price‐level data. The differences‐in‐differences approach is used, and the control group for the treatment country, Estonia, is built from 12 eurozone countries. The Nielsen Company disaggregated price data are employed at product, brand and shop‐type levels. The results indicate that while the overall inflationary effect of euro adoption was modest, the effects were significantly different across various market segments. Changeover‐related inflation was higher for products that were relatively cheaper than the eurozone average. Inflationary effects were stronger in smaller shops.
Desensitizing toothpaste versus placebo for dentin hypersensitivity: a systematic review and meta‐analysis
Authors: Bae Ji‐Hyun , Kim Young‐Kyun , Myung Seung‐Kwon 
Published: December 2014

AbstractAimThe aim is to assess the effect of desensitizing toothpaste on dentin hypersensitivity.MethodsWe searched PubMed, CENTRAL, and Embase on December 20, 2013.ResultsOut of the 626 articles searched, a total of 31 randomized controlled clinical trials were included. The Standardized mean differences (SMD) for potassium‐containing toothpaste (n = 8) was −1.28 (95% Confidence interval (CI) −2.05 to −0.51; I2 = 93%); Stannous fluoride‐ (n = 6) was −1.37 (95% CI, −2.30 to −0.44; I2 = 95%); Potassium and stannous fluoride‐ (n = 3) was −2.50 (95% CI, −4.10 to −0.91; I2 = 95%); Calcium sodium phosphosilicate‐ (n = 4) was −2.36 (95% CI, −3.72 to −1.00; I2 = 92%); Arginine‐ (n = 8) was −3.25 (95% CI, −3.87 to −2.63; I2 = 86%). The desensitizing effect was favoured in the intervention group treated with potassium‐, stannous fluoride‐, potassium and stannous fluoride‐, calcium sodium phosphosilicate‐, and arginine‐containing toothpaste compared to placebo. Whereas, strontium‐containing toothpaste (SMD, 0.05; 95% CI, −0.34 to 0.44; I2 = 64%) was found to have no statistically significant desensitizing effect in the meta‐analysis of four studies.ConclusionsThe study reports that there is sufficient evidence to support the use of potassium‐, stannous fluoride‐, potassium and stannous fluoride‐, calcium sodium phosphosilicate‐, and arginine‐containing desensitizing toothpastes for dentin hypersensitivity, but not the use of strontium‐containing desensitizing toothpaste.