bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bergenin mitigates neuroinflammatory damage induced by high glucose: insights from Zebrafish, murine microbial cell line, and rat models
Authors: Yu Wenjing , Luo Rongsiqing , He Chunxiang , Li Ze , Yang Miao , Zhou Jinyong , He Jiawei , Chen Qi , Song Zhenyan , Cheng Shaowu 
Published: August 2024

BackgroundThe escalating global burden of diabetes and its associated cognitive impairment underscores the urgency for effective interventions. Bergenin shows promise in regulating glucose metabolism, mitigating inflammation, and improving cognitive function. Zebrafish models offer a unique platform for assessing drug efficacy and exploring pharmacological mechanisms, complemented by subsequent investigations in cell and rat models.MethodsThe experimental subjects included zebrafish larvae (CZ98:Tg (mpeg1:EGFP)ihb20Tg/+), adult zebrafish (immersed in 2% glucose), BV2 cell line (50 mM glucose + 10 μm Aβ1-42), and a streptozotocin (STZ) bilateral intracerebroventricular injection rat model. Bergenin’s effects on the toxicity, behavior, and cognitive function of zebrafish larvae and adults were evaluated. The Morris water maze assessed cognitive function in rats. Neuronal histopathological changes were evaluated using HE and Nissl staining. qPCR and Western blot detected the expression of glycolysis enzymes, inflammatory factors, and Bergenin’s regulation of PPAR/NF-κB pathway in these three models.Results1) In zebrafish larvae, Bergenin interventions significantly reduced glucose levels and increased survival rates while decreasing teratogenicity rates. Microglial cell fluorescence in the brain notably decreased, and altered swimming behavior tended to normalize. 2) In adult zebrafish, Bergenin administration reduced BMI and blood glucose levels, altered swimming behavior to slower speeds and more regular trajectories, enhanced recognition ability, decreased brain glucose and lactate levels, weakened glycolytic enzyme activities, improved pathological changes in the telencephalon and gills, reduced expression of pro-inflammatory cytokines, decreased ins expression and increased expression of irs1, irs2a, and irs2b, suggesting a reduction in insulin resistance. It also altered the expression of pparg and rela. 3) In BV2 cell line, Bergenin significantly reduced the protein expression of glycolytic enzymes (GLUT1, HK2, PKFKB3, and PKM2), lowered IL-1β, IL-6, and TNF-α mRNA expression, elevated PPAR-γ protein expression, and decreased P-NF-κB-p65 protein expression. 4) In the rat model, Bergenin improves learning and memory abilities in STZ-induced rats, mitigates neuronal damage in the hippocampal region, and reduces the expression of inflammatory factors IL-1β, IL-6, and TNF-α. Bergenin decreases brain glucose and lactate levels, as well as glycolytic enzyme activity. Furthermore, Bergenin increases PPARγ expression and decreases p-NF-κB p65/NF-κB p65 expression in the hippocampus.ConclusionBergenin intervenes through the PPAR-γ/NF-κB pathway, redirecting glucose metabolism, alleviating inflammation, and preventing high glucose-induced neuronal damage.
The influence of static and dynamic warm-up on knee temperature: infrared thermography insights before and after a change of direction exercise
Authors: Trovato Bruno , Sortino Martina , Petrigna Luca , Roggio Federico , Musumeci Giuseppe 
Published: August 2024

IntroductionInfrared thermography is gaining attention in the field of sports medicine and performance. This study investigated the effects of static and dynamic warm-ups and a 90° change of direction (COD) exercise on the thermal response of the knee.MethodsThermograms were collected using the FlIR E54 Imaging Camera from 85 healthy young adults, 46 men and 39 women, aged 20–31 years. The participants were divided in two groups, static and dynamic warm-up. Four thermograms were taken: baseline (T0), warm-up (T1), COD (T2), and rest (T3). Four regions of interest (ROIs) of the knee were analyzed: anterior upper half (AUH), anterior lower half (ALH), posterior upper half (PUH), and posterior lower half (PLH). Mixed ANOVA with the Bonferroni–Holm test and independent t-test were used for pairwise comparison and to spot differences between the right and left knees at T1 and T2 and at T0 between men and women, respectively.ResultsThe mixed ANOVA was significant for time points (p&lt; 0.001) in all the ROIs and for the stretching/temperature interaction with different levels of significance. The t-test results for the right and left knees at T1 and T2 were not significant. The temperature in the static warm-up group followed a decrease at T1, a subsequent decrease at T2, and a recovery similar to the baseline at T3, in the ALH in men and women and in the PUH only in men.ConclusionStatic stretching was more suitable for preparing the knee for the COD exercise than the dynamic one in terms of the thermal response.
Balanced anesthesia in pigeons (Columba livia): a protocol that ensures stable vital parameters and feasibility during long surgeries in cognitive neuroscience
Authors: Serir A. , Tuff J. M. , Rook N. , Fongaro E. , Schreiber T. , Peus E. , Güntürkün O. , Manahan-Vaughan D. , Rose J. , Pusch R. 
Published: August 2024

In neuroscience, numerous experimental procedures in animal models require surgical interventions, such as the implantation of recording electrodes or cannulas before main experiments. These surgeries can take several hours and should rely on principles that are common in the field of research and medicine. Considering the characteristics of the avian respiratory physiology, the development of a safe and replicable protocol for birds is necessary to minimize side effects of anesthetic agents, circumvent technical limitations due to the insufficient availability of patient monitoring, and to maintain stable intraoperative anesthesia. Through the consistent and responsible implementation of the three R principle of animal welfare in science (“Replace, Reduce, Refine”), we aimed to optimize experimental methods to minimize the burden on pigeons (Columba livia) during surgical procedures. Here, surgeries were conducted under balanced anesthesia and perioperative monitoring of heart rate, oxygen saturation, body temperature, and the reflex state. The protocol we developed is based on the combination of injectable and inhalative anesthetic drugs [ketamine, xylazine, and isoflurane, supported by the application of an opiate for analgesia (e.g., butorphanol, buprenorphine)]. The combination of ketamine and xylazine with a pain killer is established in veterinary medicine across a vast variety of species. Practicability was verified by survival of the animals, fast and smooth recovery quantified by clinical examination, sufficiency, and stability of anesthesia. Independent of painful stimuli like incision or drilling, or duration of surgery, vital parameters were within known physiological ranges for pigeons. Our approach provides a safe and conservative protocol for surgeries of extended duration for scientific applications as well as for veterinary medicine in pigeons which can be adapted to other bird species.
Personality disorders in individuals with functional seizures: a systematic review
Authors: Sammarra Ilaria , Martino Iolanda , Marino Laura , Fortunato Francesco , Gambardella Antonio 
Published: August 2024

Functional seizures (FS) are classified as conversion disorders in the DSM-5 and dissociative disorders in the ICD-11, showing a multifactorial psychopathology with various psychiatric comorbidities, such as depression and anxiety. Several studies have found a correlation between FS and personality disorders, mainly those in cluster B. Within this cluster, borderline personality disorder (BPD) or borderline personality traits are the most prevalent in FS. Emotion dysregulation is a hallmark of BPD and is commonly reported in individuals with FS. Cluster C personality disorders, such as avoidant or obsessive-compulsive disorders, have also been reported in FS. In this review, we aim to evaluate the relationship between FS and personality disorders. Assessing personality disorders in the context of FS is relevant for determining the most appropriate intervention. Cognitive-behavioral therapy (CBT) is considered the first-line approach to treating FS. Among various CBT strategies, dialectical behavior therapy, which specifically targets emotion dysregulation, may be helpful for individuals with BPD. Future research should assess the advantages of systematically evaluating personality disorders in FS to address specific treatment planning and evaluate its effectiveness on seizure recurrence, psychological comorbidities, and quality of life.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPEROFILES/509286_STRATEGY_20240203.pdf, identifier CRD42024509286.
Correction criteria for the qualitative analysis of the prison population: drugs possession/consumption and gender violence
Authors: Muñoz-López Lucas , Fernández García-Valdecasas Borja , López-Rodríguez Slava , Aguilar-Yamuza Beatriz 
Published: August 2024

IntroductionPeople with language difficulties cannot face challenges related to social skills. Those language disorders affect academic, work environments, and social interaction, leading to maladaptive and aggressive behaviors. Young inmates are at high risk of experiencing unrecognized language deficiencies. It is, therefore, necessary to analyze linguistic pathologies that can influence criminal behavior (drugs possession/consumption and gender violence crimes). There are many standardized tests to evaluate and detect language difficulties in adults in English. However, there are relatively few options in Spanish; there are no tests that evaluate language qualitatively and in depth. Most of the research is conducted with children and adolescents.ObjectivesTo propose a reliable coding system for the correction and interpretation of narratives (essays and narratives) from the Battery for the Evaluation of Writing Processes (PROESC) in the prisoners charged of drugs possession or consumption and gender violence crimes.DesignThe sample was composed of 287 men.Main outcome measuresThey completed the Demographic, Offense, and Behavioral Interview in Institutions, the International Personality Disorders Examination (IPDE), and PROESC.ResultsWe found that the proposed coding system presented high concordance, that is, high inter-rater reliability.ConclusionThe classification system for the correction and interpretation of narratives was shown to be reliable.
Prevalence of stigma towards mental illness among Portuguese healthcare professionals: a descriptive and comparative study
Authors: Torres Inês N. , Pereira Helena P. , Moreira Maria Beatriz P. , Marina Sílvia , Ricou Miguel 
Published: August 2024

BackgroundStigmatising attitudes among healthcare professionals can hinder access to healthcare, making it important to address this issue. This study aimed to investigate the prevalence of stigma related to mental illness among Portuguese healthcare professionals and to compare the results among mental health professionals, General Practitioners (GPs) and other health professionals.MethodsAn online cross-sectional observational study was conducted in Portugal using Google Forms® to collect data. The data collection process lasted five months, from September 2023 to January 2024. Participants were recruited from various professional associations and Health Centre Groups, through a purposive sampling. The study used the Portuguese version of the Opening Minds Stigma Scale for Healthcare Providers (OMS-HC) to measure stigma which assesses three dimensions: attitudes towards disclosure and help-seeking, attitudes towards people with mental illness, and attitudes towards social distance.ResultsA total of 292 healthcare professionals participated in the study. In Portugal, healthcare professionals displayed low to moderate levels of stigma towards mental illness (M = 22.17, SD = 5.41). Mental health professionals demonstrated significantly lower levels of stigma (M=20.37, SD=5.37) compared to other healthcare professionals (M=24.15, SD=4.71), including GPs (M=23.97, SD=5.03). Additionally, having a close friend or relative with mental illness seemed to be related with lower levels of stigma for the dimension attitudes towards social distance (M=6.93, SD=2.50), compared to not having one (M=7.60, SD=2.56). On the other hand, a personal history of mental illness indicated higher levels of stigma for the dimension disclosure and help-seeking (M=8.95, SD=3.07), compared to having no history of mental illness (M=8.16, SD=2.67).ConclusionThis study indicates that Portuguese healthcare professionals have stigmatising attitudes towards mental illness, although at low to moderate levels. Training and frequent interaction with people with mental illness seem to be associated with lower levels of stigma. Personal experience of mental illness seems to follow the opposite path regarding disclosure and seeking help. Thus, further research is necessary to evaluate the effectiveness of anti-stigma measures and deepen the study of the concept of self-stigma in healthcare professionals.
Sustainability of pneumococcal conjugate vaccination in Ghana: a cost-effectiveness analysis in the context of donor transition
Authors: Ibrahim Abdul-Mumin , Owusu Richmond , Nonvignon Justice 
Published: August 2024

BackgroundStreptococcus pneumonia is responsible for 18% of infant deaths in Ghana. With co-financing from Gavi in 2012, Ghana introduced the PCV13 into the childhood immunization programme to reduce the burden of Streptococcus pneumonia. However, Ghana will graduate to the Gavi fully self-financing phase in 2026, when the nation assumes full responsibility of paying for the PCV13. This research aims to evaluate the health impact and cost-effectiveness of PCV13 immunization in Ghana since its implementation and after the cessation of support from Gavi.MethodsWe used the UNIVAC tool to evaluate two main scenarios of cost-effectiveness, from vaccine introduction (2012–2025) and after Gavi transition (2026–2031) in comparison with no vaccination. The sources of data include national data, international estimates and expert opinion. Cost was considered from both the government and societal perspectives. We discounted health outcomes at 3%. Currency values were stated in US Dollars. We tested the robustness of the base case results by performing scenario and sensitivity analyses.ResultsPCV13 will reduce the pneumococcal disease burden by 48% from 2012 to 2031. The vaccination programme costs are USD 130 million and USD 275 million in 2012–2025 and 2026–2031 respectively. It also has a budget impact of USD 280 million for the 2026–2031 period from the perspective of government. The incremental cost-effectiveness ratios are USD 89 and USD 73 respectively from the perspectives of government and society in 2012–2025. The incremental cost-effectiveness ratios are USD 530 and USD 510 respectively from the perspectives of government and society in 2026–2031.ConclusionThe PCV13 vaccination programme in Ghana is cost-effective at 50% GDP per capita threshold even when Gavi withdraws co-financing support from 2026 onwards.
The Nutritional Quality of the Culture Medium Influences the Survival of Non-Saccharomyces Yeasts Co-Cultured with Saccharomyces cerevisiae
Authors: Acosta-García Erick D. , Soto-Cruz Nicolás O. , Valdivia-Hernández Edwin A. , Rojas-Contreras Juan A. , Moreno-Jiménez Martha R. , Páez-Lerma Jesús B. 
Published: August 2024

Yeast-yeast interactions have been studied mainly using wine yeasts. However, studies are rare for native yeasts from agave juice fermentation. Therefore, this work used strains isolated from the alcoholic fermentation of agave to study the survival of non-Saccharomyces yeasts co-cultivated with Saccharomyces cerevisiae in media of different nutritional qualities. First, the feasibility of using simple and low-cost culture media was demonstrated to study the interactions between Saccharomyces cerevisiae and non-Saccharomyces yeasts. The results presented here demonstrated the antagonistic effect exerted by S. cerevisiae on Torulaspora delbrueckii, which showed a more significant loss of viability. However, the nutritional composition of the culture medium also influences this effect. It was clear that a nutritionally rich medium improved the survival of non-Saccharomyces yeasts. Lastly, the change in the survival of non-Saccharomyces yeasts also entails a variation in the concentration and diversity of minor volatile compounds produced during fermentation. This was observed in the variety and relative abundance of compounds belonging to the most numerous chemical families, such as alcohols, esters, and terpenes.
Nota editorial
Authors: Fisgativa Carlos Mario 
Published: August 2024

Con la publicación de este número, la revista Disertaciones llega a 14 años de actividad editorial como revista digital de acceso abierto. Lo que constituye un aporte del Programa de filosofía de la Universidad del Quindío a la diseminación del conocimiento y de la actividad filosófica desde Colombia. Son 19 ediciones y más de 100 artículos los que han sido publicados, lo que constituye un valioso archivo generado por este ejercicio editorial, el cual esperamos cobre mayor relevancia, dado el contexto de disputa acerca de la necesidad de democratizar el acceso a la información y a los resultados de procesos de investigación. Para lo cual el sistema de revistas de acceso abierto (Open Journal Systems) es una herramienta confiable.
Mysterious Element in Surfacing by Margaret Atwood
Authors: Malathi V P 
Published: August 2024

Margaret Atwood was born in Ottawa, Canada. She has done her master degree in Radcliffe College. In her childhood, she spends most of her life in wood; eventually she is interested in environmental issues. Her second novel is Surfacing, published in 1972. In the novel, she explores the theme of adventurous journey in the wood. The protagonist in the novel Surfacing is unnamed character who lives in illusion. Her past childhood affects her present life. The story begins in Quebec where the cultural difference existed. The narrator is mentally distributed by cultural difference, since she belongs to American culture; she is unable to cope with any other one. Quebec is occupied by majority of French people who resides in Canada. In Surfacing, the narrator experiences the secret of the life. She doesn’t know how her father is mysteriously died. Especially in an unknown terrain every things seems to be mysterious. The novel takes the reading like fairy tale. The protagonist recollects the memories of the past which mirrored Atwood’s character. The novel also reflects a psychological thriller, mystery and a landscape.
INVENTORY OF GREEN PLANTATIONS IN THE RECREATION PARK “PERVOMAYSKIY” IN CITY OF UFA
Authors: Исяньюлова Регина Рафаилевна , Габделхаков Айдар Кавилович 
Published: August 2024

Целью исследования является инвентаризация и оценка состояния насаждений, анализ состояния древесных видов и разработка рекомендаций по пространственному размещению элементов ландшафтной архитектуры парка культуры и отдыха «Первомайский» г. Уфы. Парк располагается в черте города, рядом с промышленными предприятиями. Территория парка богата зелеными насаждениями, что в несколько раз уменьшает негативное воздействие на человека и окружающую среду. Дана количественная и качественная оценка насаждений в динамике с 2008 по 2018 г. По данным проведенной инвентаризации площадь парка сократилась на 2,4 га, а количество деревьев на 578 экземпляров. Произошло увеличение видового состава деревьев до 19, кустарников - 9. Произрастают цветущие древесные растения, посадки в группах свидины (Córnus álba), боярышника (Fructus Crataegi), сирени обыкновенной (Syrínga vulgáris), снежноягодника (Symphoricarpos albus) и одиночные высаженные кусты черемухи обыкновенной (Pádus avium Mill.), дерена белого (Córnus álba) и жимолости (Lonícera) не оставляют равнодушными горожан. Их основная часть сосредоточена в главной части парка. Живая изгородь в парке создана из пузыреплодника (Physocarpus opulifolius), снежноягодника, дерена белого (Córnus álba) и спиреи иволистной (Spiraéa salicifolia) вдоль дорожек. Рекомендуются мероприятия по улучшению состояния и уходу за деревьями и кустарниками, по оформлению отдельных участков парка.
The purpose of the study is conducting an inventory and assessment of the state of plantations, analysis of the state of tree species and the development of recommendations for the spatial distribution of elements of the landscape architecture of the Pervomaisky recreation park in Ufa. The park is located in the city, next to industrial enterprises. The territory of the park is rich in greenery and contributes to reducing negative impact on humans and the environment. The quantitative and qualitative assessment of plantations in the period from 2008 to 2018 is given. According to the inventory, the area of the park has decreased by 2.4 hectares, and the number of trees by 578 copies. There was an increase in tree species by 19 species, shrubs - by 9. There are woody plants, svidiny (Córnus álba) grou plants, hawthorn (Fructus crataegi), common lilac (Syrínga vulgáris), snowberry (Symphoricarpos albus). As for trees of bird cherry (Pádus avium Mill.), White deren (Córnus álba) and honeysuckle (Lonícera) they do not leave the citizens indifferent. They are mainly found in the center of the park. The park hedges along the tracks are formed with plantation of Physicarpus opulifolius, a snowberry, a white derean (Córnus álba), and a willow spirea (Spiraéa salicifolia). The recommendations to improve the state and measures on taking care of trees and shrubs, for improvement individual sections of the park have been made.
КЫРГЫЗ ЭТНОСУНУН (БЫТЫРАНДЫЛЫК) ЭЛЕМЕНТТЕРИ
Authors: Алмакучуков К.М. 
Published: August 2024

Национально-государственное строительство требует знания природы общества. В социологии стараются не использовать понятие «общество», потому что нет никакого общества, а есть разные формы социальных связей. Кыргызстанское общество фрагментировано и состоит из социальных подмножеств, несущих отпечатки собственных ментальных и когнитивных сущностей. Теоретические исследования имеют прямой выход на практику национально-государственного строительства путем осуществления поиска ответа на вопрос как между этими множествами и внутри их осуществляется самоорганизация и взаимодействие, на изучение ритмов схождений и расхождений множеств.
Улуттук мамлекет куруу коомдун табиятын билүүнү талап кылат. Социология илиминде «коом» түшүнүгүн колдонбоого аракет кылышат, анткени коом деген нерсе, бирок социалдык байланыштардын ар кандай формалары бар. Кыргыз коому бытыранды жана өзүнүн психикалык жана когнитивдик маңызын чагылдырган социалдык бөлүктөрдөн турат. Теориялык изилдөөлөрдө бул топтомдордун ортосунда жана алардын ичинде өзүн өзү уюштуруу жана өз ара аракеттенүү кантип ишке ашат деген суроого жооп издөө, топтомдордун конвергенция жана дивергенция ыргактарын изилдөө аркылуу улуттук мамлекет куруунун практикасына түздөн-түз жетүү мүмкүнчүлүгүнө ээ.
National-state construction requires knowledge of the nature of society. In sociology, attempts are being made not to use the concept of “society”, because there is no society, but there are different forms of social connections. The Kyrgyzstan’s society is fragmented and consists of social subsets bearing the imprints of their own mental and cognitive entities. Theoretical research has a direct access to the practice of national-state construction by searching for an answer to the question of how self-organization and interaction are carried out between these sets and within them, to study the rhythms of multiple convergence and divergence.