bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Possible Neural Basis for Attentional Capture of Faces Revealed by Functional Magnetic Resonance Imaging and Causal Pharmacological Inactivation in Macaques
Authors: Liu Ning , Avidan Galia , Turchi Janita N. , Hadj-Bouziane Fadila , Behrmann Marlene 
Published: June 2024

Abstract
In primates, the presence of a face in a visual scene captures attention and rapidly directs the observer's gaze to the face, even when the face is not relevant to the task at hand. Here, we explored a neural circuit that might potentially play a causal role in this powerful behavior. In our previous research, two monkeys received microinfusions of muscimol, a γ-aminobutyric acid type A (GABAA)-receptor agonist, or saline (as a control condition) in separate sessions into individual or pairs of four inferotemporal face patches (middle and anterior lateral and fundal), as identified by an initial localizer experiment. Then, using fMRI, we measured the impact of each inactivation condition on responses in the other face patches relative to the control condition. In this study, we used the same method and measured the impact of each inactivation condition on responses in the FEF and the lateral intraparietal area, two regions associated with attentional processing, while face and nonface object stimuli were viewed. Our results revealed potential relationships between inferotemporal face patches and these two attention-related regions: The inactivation of the middle lateral and anterior fundal face patches had a pronounced impact on FEF, whereas the inactivation of the middle and anterior lateral face patches had a noticeable influence on LIP. Together, these initial exploratory findings document a circuit that potentially underlies the attentional capture of faces. Confirmation of the role of this circuit remains to be accomplished in the context of a paradigm that explicitly tests the attentional capture of faces.
Time after Time: Preserving Temporal Memories When Experiences Repeat
Authors: Zou Futing , Kuhl Brice A. 
Published: June 2024

Abstract
Remembering when events occur in time is fundamental to episodic memory. Yet, many experiences repeat over time creating the potential for interference when attempting to recall temporally specific memories. Here, we argue that temporal memories are protected, in part, by reinstatement of temporal context information that is triggered by stimulus repetitions. We motivate this argument by integrating seminal findings across several distinct literatures and methodologies. Specifically, we consider key insights from foundational behavioral studies of temporal memory, recent electrophysiological and neuroimaging approaches to measuring memory reinstatement, and computational models that describe how temporal context representations shape memory processes. We also note several open questions concerning how temporal context reinstatement might influence subsequent temporal memory, including potential mediating effects of event spacing and event boundaries. These ideas and questions have the potential to guide future research and, ultimately, to advance theoretical accounts of how we preserve temporal memories.
Conducting Developmental Research Online vs. In-Person: A Meta-Analysis
Authors: Chuey Aaron , Boyce Veronica , Cao Anjie , Frank Michael C. 
Published: June 2024

Abstract
An increasing number of psychological experiments with children are being conducted using online platforms, in part due to the COVID-19 pandemic. Individual replications have compared the findings of particular experiments online and in-person, but the general effect of data collection method on data collected from children is still unknown. Therefore, the goal of the current meta-analysis is to estimate the average difference in effect size for developmental studies conducted online compared to the same studies conducted in-person. Our pre-registered analysis includes 211 effect sizes calculated from 30 papers with 3282 children, ranging in age from four months to six years. The estimated effect size for studies conducted online was slightly smaller than for their counterparts conducted in-person, a difference of d = −.05, but this difference was not significant, 95% CI = [−.17, .07]. We examined several potential moderators of the effect of online testing, including the role of dependent measure (looking vs verbal), online study method (moderated vs unmoderated), and age, but none of these were significant. The literature to date thus suggests—on average—small differences in results between in-person and online experimentation.
Tropical Cyclone Boundary Layer Asymmetries in a Tilt-Following Perspective
Authors: Yu Chau-Lam , Tang Brian , Fovell Robert G. 
Published: June 2024

Abstract
Previous observations and modeling studies showed that tropical cyclones (TCs) in a sheared environment develop an asymmetric boundary layer (BL). While the relationship between the BL asymmetries and environmental shear has been demonstrated, the exact cause of these BL asymmetries and the phase relationship between them are less well understood. In this study, we examine the dynamical processes leading to the asymmetric structure of the TC BL in a sheared environment using idealized, convection-permitting model simulations. Our results show that the emergence of the BL asymmetries is closely linked to the TC vortex tilt and rainband processes. Specifically, stratiform diabatic processes in the downtilt-left region result in midlevel descending inflow, which brings midtropospheric, low-θE air toward the BL and forms a surface cold pool in the downtilt-left quadrant. This descending inflow also advects high absolute angular momentum inward, redistributing the vertical vorticity and causing a storm-scale tangential wind acceleration within the downtilt-left quadrant. As the BL low-θE air advances inward, it becomes supergradient and decelerates radially, forming BL outflow in the uptilt-left quadrant. The outflow advects positive relative vorticity uptilt, forming an elliptic BL vorticity and circulation structure. As the tilted TC vortex and the accompanying rainband precess cyclonically over time, the above sequence of events and the resultant BL asymmetries also precess cyclonically, maintaining a quasi-stationary configuration relative to the vortex tilt. These results suggest that the primary organizing factor of the boundary layer asymmetries is the tilted vortex structure and not strictly the environmental shear direction.
Investigating the Potential of Using Mixdown Altitudes to Forecast Peak Wind Gusts
Authors: Kahl Jonathan D. W. , Zaprzalka Kacper J. , Brezovar Danica S. , Lang Victoria A. , Selbig Brandon R. , Harris Austin R. 
Published: June 2024

Abstract
Forecast models based on the gust factor, the ratio of peak gust to sustained wind speed, have shown promise in predicting peak wind gusts in recent years. These models assume that turbulent vertical transport forced by wind flowing over upstream terrain mixes high-momentum air aloft down to the surface. A recently constructed database of hourly peak gusts, together with approximately coincident, nearby upper-air wind observations, is used to identify mixdown altitudes, the altitudes from which peak gusts descend, during different weather scenarios at 16 locations across the United States. Median mixdown altitudes generally ranged from 50 to 450 m AGL with occasional exceptions, particularly for convective gusts and at mountainous locations where terrain effects are likely to amplify gusts. A mixdown model in which surface peak gusts are predicted by obtaining forecast upper-air winds within this altitude interval was developed and tested. Our results suggest that a mixdown model methodology for forecasting peak gusts may be feasible at locations and during weather conditions where terrain-forced turbulent mixing is the principal cause of wind gusts.
Diagnosing Adolescent Substance Use and Co‐Occurring Disorders Using the Global Appraisal of Individual Needs Quick Version‐4
Authors: Welsh Justine W. , Durham Rebecca M. , Sitar Siara I. , Modisette Kathryn C. , Estrada Barbara D. , Dennis Michael L. 
Published: June 2024

ObjectiveEarly identification of substance use during adolescence is imperative to reduce the risk of morbidity and mortality. The aim of this study was to determine the utility of the Global Appraisal of Individual Needs‐Quick Version 4 (GAIN‐Q4) at diagnosing substance use disorders (SUDs) in adolescents.MethodsThe GAIN‐Q4 was developed from the GAIN‐Quick Version 3 by adding items from the original measure (GAIN‐I) to diagnose SUDs and provide level of care recommendations. Prevalence, sensitivity (SE), specificity, Cohen's kappa, and percent agreement between the GAIN‐I and GAIN‐Q4 were calculated for substance use and mental health (MH) diagnoses. The GAIN‐I was administered to adolescents aged 12–17 and adults across levels of care and service settings from 2002 to 2018. The sample included 101,897 adolescents (71.50% male; average age 15.59, SD = 1.25 years) and 204,711 adults aged 18 and older (61.72% male; average age 34.24; SD = 11.67).ResultsNearly half of adolescents (43%) had at least one SUD and one MH diagnosis based on the GAIN‐Q4. The sensitivity and specificity of the GAIN‐Q4 for diagnosing any SUD in adolescents was 89% and 93%, respectively. There was 90% agreement between the GAIN‐Q4 and GAIN‐I for any SUD (Cohen's kappa of 0.80). Sensitivities for all SUD subtypes were >90%.ConclusionsThe GAIN‐Q4 is excellent at identifying adolescents with problems related to co‐occurring MH and SUDs (SE = 97%). The GAIN‐Q4 is a reliable instrument for the diagnosis of SUDs in adolescents and has the potential to facilitate appropriate allocation of treatment resources.Trial registrationClinicalTrials.gov Identifier: NCT05001399.
The MAGIC algorithm probability predicts treatment response and long-term outcomes to second-line therapy for acute GVHD
Authors: DeFilipp Zachariah , Kim Haesook T. , Spyrou Nikolaos , Katsivelos Nikolaos , Kowalyk Steven , Eng Gilbert , Kasikis Stelios , Beheshti Rahnuma , Baez Janna , Akahoshi Yu , Ayuk Francis , Choe Hannah , Etra Aaron , Grupp Stephan A. , Hexner Elizabeth O. , Hogan William J. , Kitko Carrie L. , Qayed Muna , Reshef Ran , Vasova Ingrid , Zeiser Robert , Young Rachel , Holler Ernst , Ferrara James L. M. , Nakamura Ryotaro , Levine John E. , Chen Yi-Bin 
Published: June 2024

Abstract
The significance of biomarkers in second-line treatment for acute graft-versus-host disease (GVHD) has not been well characterized. We analyzed clinical data and serum samples at the initiation of second-line systemic treatment of acute GVHD from 167 patients from 17 centers of the Mount Sinai Acute GVHD International Consortium (MAGIC) between 2016 and 2021. Sixty-two patients received ruxolitinib-based therapy, whereas 102 received other systemic agents. In agreement with prospective trials, ruxolitinib resulted in a higher day 28 (D28) overall response Frate than nonruxolitinib therapies (55% vs 31%, P = .003) and patients who received ruxolitinib had significantly lower nonrelapse mortality (NRM) than those who received nonruxolitinib therapies (point estimates at 2-year: 35% vs 61%, P = .002). Biomarker analyses demonstrated that the benefit from ruxolitinib was observed only in patients with low MAGIC algorithm probabilities (MAPs) at the start of second-line treatment. Among patients with a low MAP, those who received ruxolitinib experienced significantly lower NRM than those who received nonruxolitinib therapies (point estimates at 2-year: 12% vs 41%, P = .016). However, patients with high MAP experienced high NRM regardless of treatment with ruxolitinib or nonruxolitinib therapies (point estimates at 2-year: 67% vs 80%, P = .65). A landmark analysis demonstrated that the relationship between the D28 response and NRM largely depends on the MAP level at the initiation of second-line therapy. In conclusion, MAP measured at second-line systemic treatment for acute GVHD predicts treatment response and NRM. The outcomes of patients with high MAP are poor regardless of treatment choice, and ruxolitinib appears to primarily benefit patients with low MAP.
Systemic treatment options for non-small cell lung cancer after failure of previous immune checkpoint inhibitors: a bayesian network meta-analysis based on randomized controlled trials
Authors: Wang Kang , Fu Zhenxue , Sun Guanxing , Ran Yancui , Lv Nannan , Wang Enbo , Ding Huan 
Published: June 2024

Abstract
Background
Although immune checkpoint inhibitors (ICIs) have brought survival benefits to non-small cell lung cancer (NSCLC), disease progression still occurs, and there is no consensus on the treatment options for these patients. We designed a network meta-analysis (NMA) to evaluate systemic treatment options for NSCLC after failure of ICIs.

Methods
PubMed, Embase, Web of Science and Cochrane Library databases were searched, then literature screening was followed by NMA. We included all Phase II and III randomized controlled trials (RCTs). Progression-free survival (PFS) and overall survival (OS) used hazard ratio (HR) for evaluation. Objective response rate (ORR) and adverse events (AEs) used odds ratio (OR) and relative risk (RR) effect sizes, respectively. R software was applied to compare the Bayesian NMA results.

Results
We finally included 6 studies. 1322 patients received ICI plus Chemotherapy (ICI + Chemo), ICI plus Anti-angiogenic monoclonal antibody (ICI + Antiangio-Ab), ICI plus Tyrosine kinase inhibitor (ICI + TKI), Tyrosine kinase inhibitor plus Chemotherapy (TKI + Chemo), Standard of Care (SOC), Chemotherapy (Chemo). TKI + Chemo is associated with longer PFS, higher ORR (surface under cumulative ranking curve [SUCRA], 99.7%, 88.2%), ICI + TKI achieved the longest OS (SUCRA, 82.7%). ICI + Antiangio-Ab was granted the highest safety rating for adverse events (AEs) of any grade, AEs greater than or equal to grade 3 and AEs of any grade leading to discontinuation of treatment (SUCRA, 95%, 82%, 93%).

Conclusions
For NSCLC after failure of ICIs, TKI + Chemo was associated with longer PFS and higher ORR, while ICI + TKI was associated with the longest OS. In terms of safety, ICI + Antiangio-Ab was the highest.
Molecular characterization and epidemiological investigation of colistin resistance in carbapenem-resistant Klebsiella pneumoniae in a tertiary care hospital in Tehran, Iran
Authors: Davoodi Neda Razavi , Soleimani Neda , Hosseini Seyed Masoud , Rahnamaye-Farzami Marjan 
Published: June 2024

Abstract
Background
Carbapenemase-producing Klebsiella pneumoniae (CRKP) presents a significant challenge to antimicrobial therapy, especially when compounded by resistance to colistin. The objective of this study was to explore molecular epidemiological insights into strains of clinical K. pneumoniae that produce carbapenemases and exhibit resistance to colistin. Eighty clinical isolates of CRKP were obtained from Milad Hospital in Tehran, Iran. Antimicrobial susceptibility and colistin broth disk elution were determined. PCR assays were conducted to examine the prevalence of resistance-associated genes, including blaKPC, blaIMP, blaVIM, blaOXA−48, blaNDM and mcr-1 to -10. Molecular typing (PFGE) was used to assess their spread.

Results
Colistin resistance was observed in 27 isolates (33.7%) using the Broth Disk Elution method. Among positive isolates for carbapenemase genes, the most frequent gene was blaOXA−48, identified in 36 strains (45%). The mcr-1 gene was detected in 3.7% of the obtained isolates, with none of the other of the other mcr genes detected in the studied isolates.

Conclusion
To stop the spread of resistant K. pneumoniae and prevent the evolution of mcr genes, it is imperative to enhance surveillance, adhere rigorously to infection prevention protocols, and implement antibiotic stewardship practices.
Phylogenetic incongruence in an Asiatic species complex of the genus Caryodaphnopsis (Lauraceae)
Authors: Yang Shiting , Huang Jiepeng , Qu Yaya , Zhang Di , Tan Yunhong , Wen Shujun , Song Yu 
Published: June 2024

Abstract
Background
Caryodaphnopsis, a group of tropical trees (ca. 20 spp.) in the family Lauraceae, has an amphi-Pacific disjunct distribution: ten species are distributed in Southeast Asia, while eight species are restricted to tropical rainforests in South America. Previously, phylogenetic analyses using two nuclear markers resolved the relationships among the five species from Latin America. However, the phylogenetic relationships between the species in Asia remain poorly known.

Results
Here, we first determined the complete mitochondrial genome (mitogenome), plastome, and the nuclear ribosomal cistron (nrDNA) sequences of C. henryi with lengths of 1,168,029 bp, 154,938 bp, and 6495 bp, respectively. We found 2233 repeats and 368 potential SSRs in the mitogenome of C. henryi and 50 homologous DNA fragments between its mitogenome and plastome. Gene synteny analysis revealed a mass of rearrangements in the mitogenomes of Magnolia biondii, Hernandia nymphaeifolia, and C. henryi and only six conserved clustered genes among them. In order to reconstruct relationships for the ten Caryodaphnopsis species in Asia, we created three datasets: one for the mitogenome (coding genes and ten intergenic regions), another for the plastome (whole genome), and the other for the nuclear ribosomal cistron. All of the 22 Caryodaphnopsis individuals were divided into four, five, and six different clades in the phylogenies based on mitogenome, plastome, and nrDNA datasets, respectively.

Conclusions
The study showed phylogenetic conflicts within and between nuclear and organellar genome data of Caryodaphnopsis species. The sympatric Caryodaphnopsis species in Hekou and Malipo SW China may be related to the incomplete lineage sorting, chloroplast capture, and/or hybridization, which mixed the species as a complex in their evolutionary history.
Duration of effectiveness of the COVID-19 vaccine in Japan: a retrospective cohort study using large-scale population-based registry data
Authors: Uemura Kohei , Ono Sachiko , Michihata Nobuaki , Yamana Hayato , Yasunaga Hideo 
Published: June 2024

Abstract
Background
Most evidence of the waning of vaccine effectiveness is limited to a relatively short period after vaccination.

Methods
Data obtained from a linked database of healthcare administrative claims and vaccination records maintained by the municipality of a city in the Kanto region of Japan were used in this study. The study period extended from April 1, 2020, to December 31, 2022. The duration of the effectiveness of the COVID-19 vaccine was analyzed using a time-dependent piecewise Cox proportional hazard model using the age, sex and history of cancer, diabetes, chronic obstructive pulmonary disease, asthma, chronic kidney disease, and cardiovascular disease as covariates.

Results
Among the 174,757 eligible individuals, 14,416 (8.3%) were diagnosed with COVID-19 and 936 (0.54%) were hospitalized for COVID-19. Multivariate analysis based on the time-dependent Cox regression model with reference of non-vaccine group revealed a lower incidence of COVID-19 in the one-dose group (hazard ratio, 0.76 [95% confidence interval, 0.63–0.91]), two-dose (0.89 [0.85–0.93]), three-dose (0.80 [0.76–0.85]), four-dose (0.93 [0.88–1.00]), and five-dose (0.72 [0.62–0.84]) groups. A lower incidence of COVID-19-related hospitalization was observed in the one-dose group (0.42 [0.21–0.81]), two-dose (0.44 [0.35–0.56]), three-dose (0.38 [0.30–0.47]), four-dose (0.20 [0.14–0.28]), and five-dose (0.11 [0.014–0.86]) groups. Multivariable analyses based on the time-dependent piecewise Cox proportional hazard model with reference of non-vaccine group revealed significant preventive effects of the vaccine for 4 months for the incidence of COVID-19 and ≥ 6 months for hospitalization.

Conclusions
Vaccine effectiveness showed gradual attenuation with time after vaccination; however, protective effects against the incidence of COVID-19 and hospitalization were maintained for 4 months and ≥ 6 months, respectively. These results may aid in formulating routine vaccination plans after the COVID-19 pandemic.
Comparison of clinical outcomes of pulmonary nocardiosis between AIDS and non-AIDS patients
Authors: Thipmontree Wilawan , Suputtamonkol Yupin 
Published: June 2024

Abstract
Background
Nocardia species can affect both immunocompetent and immunocompromised people.

Method
This retrospective study, from 2009 to 2022, aims to compare the survival analyses of pulmonary nocardiosis in AIDS and non-AIDS patients in northeastern Thailand.

Results
A total of 215 culture-confirmed cases of pulmonary nocardiosis: 97 with AIDS and 118 without AIDS. The median CD4 count of AIDS patients was 11 cells/µL (range: 1–198), and 33% had concurrent opportunistic infections. 63.6% of 118 non-AIDS patients received immunosuppressive medications, 28.8% had comorbidities, and 7.6% had no coexisting conditions. Disseminated nocardiosis and pleural effusion were more prevalent among AIDS patients, whereas non-AIDS patients revealed more shock and respiratory failure. One hundred-fifty patients underwent brain imaging; 15 (10%) had brain abscesses. Patients with pulmonary nocardiosis have overall 30-day and 1-year mortality rates of 38.5% (95% CI: 32.3%, 45.4%) and 52.1% (95% CI: 45.6%, 58.9%), respectively. The Cox survival analysis showed that AIDS patients with disseminated nocardiosis had a 7.93-fold (95% CI: 2.61–24.02, p < 0.001) increased risk of death within 30 days compared to non-AIDS patients when considering variables such as age, Charlson comorbidity index, concurrent opportunistic infections, duration of illness, shock, respiratory failure, multi-lobar pneumonia, lung abscesses, and combination antibiotic therapy. While AIDS and pulmonary nocardiosis had a tendency to die within 30 days (2.09 (95% CI, 0.74–5.87, p = 0.162)).

Conclusion
AIDS with pulmonary nocardiosis, particularly disseminated disease, is a serious opportunistic infection. Early diagnosis and empiric treatment with a multidrug regimen may be the most appropriate approach in a resource-limited setting.