bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection
Authors: Christensen Dan Ploug , Gysemans Conny , Lundh Morten , Dahllöf Mattias Salling , Noesgaard Daniel , Schmidt Søren Fisker , Mandrup Susanne , Birkbak Nikolai , Workman Christopher T. , Piemonti Lorenzo , Blaabjerg Lykke , Monzani Valmen , Fossati Gianluca , Mascagni Paolo , Paraskevas Steven , Aikin Reid A. , Billestrup Nils , Grunnet Lars Groth , Dinarello Charles A. , Mathieu Chantal , Mandrup-Poulsen Thomas 
Published: January 2014

Significance
Type 1 diabetes is due to immune-mediated pancreatic β-cell destruction. Lysine deacetylase inhibitors (KDACi) protect β-cells from inflammatory destruction in vitro and are promising immunomodulators. The orally active and clinically well-tolerated KDACi vorinostat and givinostat reverted diabetes in a mouse model of type 1 diabetes and counteracted inflammatory target cell damage. Importantly, these effects were achieved with doses that are safe and effective in human inflammatory diseases. Of note, the mechanism of action was compatible with transcription factor—rather than global chromatin—hyperacetylation, causing inhibition of transcription factor binding and reduction of proinflammatory gene expression in leukocytes and β-cells. These data provide a rationale for clinical trials of safety and efficacy of KDACi in patients with Type 1 diabetes.
Analysis of chromatin-state plasticity identifies cell-type–specific regulators of H3K27me3 patterns
Authors: Pinello Luca , Xu Jian , Orkin Stuart H. , Yuan Guo-Cheng 
Published: January 2014

Significance
We developed a computational approach to characterize chromatin-state plasticity across cell types, using the repressive mark H3K27me3 as an example. The high plasticity regions (HPRs) can be divided into two functionally and mechanistically distinct groups, corresponding to CpG island proximal and distal regions, respectively. We identified cell-type–specific regulators correlating with H3K27me3 patterns at distal HPRs in ENCODE cell lines as well as in primary human erythroid precursors. We predicted and validated a previously unrecognized role of T-cell acute lymphocytic leukemia-1 (TAL1) in modulating H3K27me3 patterns through interaction with additional cofactors, such as growth factor independent 1B (GFI1B). Our integrative approach provides mechanistic insights into chromatin-state plasticity and is broadly applicable to other epigenetic marks.
CGAT: computational genomics analysis toolkit
Authors: Sims David , Ilott Nicholas E. , Sansom Stephen N. , Sudbery Ian M. , Johnson Jethro S. , Fawcett Katherine A. , Berlanga-Taylor Antonio J. , Luna-Valero Sebastian , Ponting Chris P. , Heger Andreas 
Published: January 2014

Abstract
Summary: Computational genomics seeks to draw biological inferences from genomic datasets, often by integrating and contextualizing next-generation sequencing data. CGAT provides an extensive suite of tools designed to assist in the analysis of genome scale data from a range of standard file formats. The toolkit enables filtering, comparison, conversion, summarization and annotation of genomic intervals, gene sets and sequences. The tools can both be run from the Unix command line and installed into visual workflow builders, such as Galaxy.
Availability: The toolkit is freely available from http://github.com/CGATOxford/cgat
Contact: andreas.heger@dpag.ox.ac.uk
Synergistic Interaction between Fentanyl and Bupivacaine Given Intrathecally for Labor Analgesia
Authors: Ngan Kee Warwick D. , Khaw Kim S. , Ng Floria F. , Ng Karman K. L. , So Rita , Lee Anna 
Published: January 2014

Abstract

Background:
Lipophilic opioids and local anesthetics are often given intrathecally in combination for labor analgesia. However, the nature of the pharmacologic interaction between these drugs has not been clearly elucidated in humans.

Methods:
Three hundred nulliparous women randomly received 1 of 30 different combinations of fentanyl and bupivacaine intrathecally using a combined spinal-epidural technique for analgesia in the first stage of labor. Visual analogue scale pain scores were recorded for 30 min. Response was defined by percentage decrease in pain score from baseline at 15 and 30 min. Dose–response curves for individual drugs were fitted to a hyperbolic dose–response model using nonlinear regression. The nature of the drug interaction was determined using dose equivalence methodology to compare observed effects of drug combinations with effects predicted by additivity.

Results:
The derived dose–response models for individual drugs (doses in micrograms) at 15 min were: Effect = 100 × dose / (13.82 + dose) for fentanyl, and Effect = 100 × dose / (1,590 + dose) for bupivacaine. Combinations of fentanyl and bupivacaine produced greater effects than those predicted by additivity at 15 min (P < 0.001) and 30 min (P = 0.015) (mean differences, 9.1 [95% CI, 4.1–14.1] and 6.4 [95% CI, 1.2–11.5] units of the normalized response, respectively), indicating a synergistic interaction.

Conclusions:
The pharmacologic interaction between intrathecal fentanyl and bupivacaine is synergistic. Characterization and quantification of this interaction provide a theoretical basis and support for the clinical practice of combining intrathecal opioids and local anesthetics.
Value methodology in public engagement for construction development projects
Authors: Leung Mei-Yung , Yu Jingyu 
Published: January 2014

Purpose– The use of public engagement (PE) has been encouraged by the Hong Kong government in recent years, with the construction industry under particular pressure to employ it. However, society as a whole has been suffering as a result of various levels of discontent and conflict in many construction development projects. The logical paths to analyze public need and resolve conflict in the PE process are vague. Value methodology (VM), a logical method, is thus proposed as an initial framework to support PE activities in construction projects. The purpose of this paper is to enhance PE performance for the complicated construction development projects with the application of VM principles.Design/methodology/approach– Based on an extensive literature review, PE logical team process factors and PE outcomes were identified. A questionnaire survey was conducted to investigate the relationships between the logical PE team decision-making process (VM application in the logical process and team behaviors) and final PE outcomes.Findings– The results showed that the PE team process with the application of VM, especially information and analysis phases, influenced PE outcomes positively. Conflict (both destructive conflict and constructive conflict) influenced PE outcomes in different directions.Practical implications– It is recommended that the information and analysis phases of VM are applied to PE process in order to achieve consensus, cultivate team spirit, improve project performance, and enhance organizational reputation.Originality/value– This paper innovatively proposes the application of VM into the PE team process in order to analyze the project logically and subsequently improve holistic PE project performance and finally promote social cohesion.
Overview of the development and implementation of the mandatory building inspection scheme (MBIS) in Hong Kong
Authors: W.M. Chan Daniel , T.W. Hung Henry , P.C. Chan Albert , K.K. Lo Tony 
Published: January 2014

Purpose
– The purpose of this paper is to provide a concise overview of the problem of building decay in Hong Kong, the current government measures concerning dilapidated buildings and the latest development and implementation of the mandatory building inspection scheme (MBIS). A comparison of various MBISs from other jurisdictions of the world is also given.

Design/methodology/approach
– A desktop study of building inspection procedures, repair and maintenance policies was carried out, followed by an industry-wide opinion survey conducted by means of self-administered questionnaires. Target respondents are within the construction community of Hong Kong. The perceived benefits, potential difficulties and insightful recommendations or good practices are investigated. A comparison of the relative ranking of individual mean scores from various groups of respondents is presented in this paper.

Findings
– The execution of MBIS was found to be effective in enhancing public awareness of the importance of building upkeep and recognition of the property owner's legal responsibilities in this respect. Private property owners were made aware of the necessity to take holistic preventive measures to maintain the overall safety of their own buildings. A comparison of MBIS with other similar MBISs across different cities, revealed similarities as regards the inspection cycle, scope of inspection and qualifications of inspectors. The main difference related to the age rather than the height of target buildings.

Practical implications
– Proper inspection and maintenance is necessary to keep buildings in good condition to avoid injury or loss of life due to sudden collapse of structures or their elements such as concrete spalling and fall of window frames. The official launch of MBIS on 30 June 2012 is one of the proposed effective measures to resolve the long-standing problems of building neglect and deterioration in Hong Kong with particular regard to the existing old private premises.

Originality/value
– The execution of MBIS should be useful in improving the safety and health status of the dilapidated premises and in so doing safeguarding the residents and general public. To further identify the perceived benefits and potential difficulties of MBIS, and to suggest insightful recommendations or good practices for its successful future implementation, an opinion survey was launched among construction practitioners in Hong Kong between March and April of 2012.
How damaged are investment capital markets today?
Authors: El Namaki M.S.S. 
Published: January 2014

Purpose
– Investment capital markets have been displaying signs of disarray and are significantly damaged. This is especially manifest in the case of the USA and some countries in Europe. Symptoms of this damage are visible. The operators are declining in number, contracting in scale and losing in asset base. The products are losing glitter and are shunned by investors. The monitors have lost creditably. And the regulators have failed at regulating. This is the focus of the following article. An analysis of damage incurred within the investment capital market and the possible projection of damage parameters within a conceptual and operational model. The paper aims to discuss these issues.

Design/methodology/approach
– The paper starts with a definition of the damage concept, proceeds to relate damage to four forces, i.e. players, products, monitors and regulators and concludes with a conceptual and operational model for damage analysis. The paper is eclectic relying on finance, macro-economic and strategic management analytically frameworks.

Findings
– A definition of investment capital market damage is proposed and an identification of several strains of this damage is made. Prime among the strains is malignant operator concentration, monitor misleading self-interest and product failure. The damage concept could be contained within a conceptual and operational model.

Practical implications
– The derived model could provide a base for countrywide investment capital market damage level assessment and directions for policy and strategy response especially for organizations as the World Bank and the IMF.

Originality/value
– The issue addressed is possibly never conceptually tackled within investment capital market analysis.
Supply chain integration and firm performance: an empirical study of Swedish manufacturing firms
Authors: M. Beheshti Hooshang , Oghazi Pejvak , Mostaghel Rana , Hultman Magnus 
Published: January 2014

Purpose
– This article aims to explore the impact of supply chain integration on the financial performance of Swedish manufacturing firms.

Design/methodology/approach
– The literature review provided the foundation for the development of the survey instrument and hypotheses for the study. In addition, the survey instrument was tested by the experts in the field and modified before it was sent to the managers in the survey group.

Findings
– The findings show that supply chain integration at any level is beneficial to the financial well being of the firm. Companies with total supply chain integration reported the highest level of financial performance.

Research limitations/implications
– Data were collected from Swedish manufacturing firms without regard to the size of the firm. The results show that supply chain integration is beneficial at any level.

Practical implications
– The findings will assist managers with decisions regarding supply chain integration and its role as a critical factor in improving the financial performance of manufacturing companies.

Originality/value
– Limited empirical studies have been conducted in this area, especially in Sweden. This study provides insight for manufacturing managers with regard to the importance of supply chain management and the competitive nature of business in the global market.
Solar trade tariffs
Authors: Abboushi Suhail 
Published: January 2014

Purpose
– The purpose of this paper is to survey the growth of solar energy worldwide, analyze US-China trade dispute in the solar industry, and evaluate the merits of US trade tariffs.

Design/methodology/approach
– The study surveyed archival data, publications by international organizations, government agencies, industry groups, and some academic research papers.

Findings
– Global demand for solar energy has been rising steadily and is projected to generate growing source of electric power. There is worldwide consensus that public support for solar industry in the development stages is necessary. The US Government provides generous support programs and subsidies to US solar industry. Accordingly, US punitive tariffs against China's solar industry on grounds of government subsidies are of questionable merit.

Originality/value
– This paper presents a concise profile of global solar energy and evaluates US trade policy toward China. The findings can be of value to government officials as they consider trade policies and their impact on the future of solar energy.
Determinants of attitude of teachers – factor analysis and strategies for success
Authors: Trehan Ruchi , Paul Justin 
Published: January 2014

Purpose
– Attitude is a major factor affecting behavior. It influences the perception of objects and people, exposure to and comprehension of information, choice of friends, co-workers and so on. Attitudes are subjective attributes of people. Attitude is nothing but conceptualization of human qualities that are formed on the basis of either rational consideration or statistical evidence. Thus, people may vary along each of a number of attitudinal dimensions. Keeping this measurement aspect into consideration, the attitudes might be defined operationally by describing the measurement systems that psychologists use to measure attributes. There are many methods of attitude measurement, i.e. self-report, indirect tests, direct observation techniques, and psychological reaction techniques. This study aims at enquiring into quality of working life differentials among teachers with a view to bring to the surface some of the conditions in context of job satisfaction categorically.

Design/methodology/approach
– This study has been designed to address the objectives given below: to analyse quality of working life differentials among urban and rural school teachers; to compare the urban and rural teaching environment on the basis of job satisfaction criteria like teaching and welfare facilities. The research has been conducted in government schools in India. It was carried out with two samples of 200 teachers each from the urban and the rural area. Primary data were collected and factor analysis was carried out, as a tool.

Findings
– The analysis reveals that in case of urban teachers, the factors identified as important in quality of working life include-excellence and satisfaction at work, intra-institutional satisfaction, peer group pressure, lower self-esteem, institutional and social pressures, overall organizational satisfaction and socio-organisational behaviour. On the other hand, in the case of rural teachers, seven factors have been identified as factors determining of quality of work, which are not the same factors as identified in the case of urban teachers.

Originality/value
– This comparative study has implications on competitiveness of teachers and their work performance. The educational institutions those who focus on the factors determining the quality of work life will have more opportunities to emerge as successful organizations.
Innovation, happiness, and growth
Authors: J. Ali Abbas 
Published: January 2014

Purpose
– The purpose of this paper is to discuss the role of innovation in society. It explores the relationship between societal happiness and economic growth and how innovation is linked to both issues.

Design/methodology/approach
– The paper briefly discusses the concept of innovation and the instrumental role that innovative people play in generating wealth and sustaining confidence and dedication among the widest possible segment of society.

Findings
– Based on economic logic and social perspectives, it is argued that innovation is not merely an economic issue but also a social factor that is characteristically linked to societal wellbeing and the position of a nation in the global marketplace.

Originality/value
– The paper offers a unique perspective on innovation and argues that it is a fatal mistake to view innovation as independent of the social and political aspects of any society. The paper sets the stage for an effective dialogue by which the essence of innovation, optimism, and economic growth can be recognized and reflected on as interrelated issues.
Towards a rapid automatic detection of building damage using remote sensing for disaster management
Authors: Pham Thi-Thanh-Hiên , Apparicio Philippe , Gomez Christopher , Weber Christiane , Mathon Dominique 
Published: January 2014

Purpose– Satellite and airborne images are increasingly used at different stages of disaster management, especially in the detection of infrastructure damage. Although semi- or full automatic techniques to detect damage have been proposed, they have not been used in emergency situations. Damage maps produced by international organisations are still based on visual interpretation of images, which is time- and labour-consuming. The purpose of this paper is to investigate how an automatic mapping of damage can be helpful for a first and rapid assessment of building damage.Design/methodology/approach– The study area is located in Port-au-Prince (Haiti) stricken by an earthquake in January 2010. To detect building damage, the paper uses optical images (15 cm of spatial resolution) coupled with height data (LiDAR, 1 m of spatial resolution). By undertaking an automatic object-oriented classification, the paper identifies three categories of building damages: intact buildings, collapsed buildings and debris.Findings– Data processing for the study area covering 11 km2 took about 15 hours. The accuracy of the classification varies from 70 to 79 per cent depending to the methods of assessment. Causes of errors are numerous: limited spectral information of the optical images, resolution difference between the two data, high density of buildings but most importantly, certain types of building collapses could not be detected by vertically taken images (the case of data in this study).Originality/value– The automatic damage mapping developed in this paper proves to be reliable and could be used in emergency situations. It could also be combined with manual visual interpretation to accelerate the planning of humanitarian rescues and reconstruction.
A case productivity model for automatic climbing system
Authors: Zayed Tarek , Mohamed Elsayed 
Published: January 2014

Purpose
– Tight schedules in high-rise building construction force project managers to use the formwork even in a bad weather condition. Insufficient craning, which is typically the bottleneck in construction activities, and lack of space in confined sites make it hard to install the formwork on the ground. The Automatic Climbing System (ACS), a type of jump forms, solves these problems enabling the formwork to climb in various weather and height conditions. The aim of this paper is to discuss these issues.

Design/methodology/approach
– Current research focusses on the ACS, its application, and productivity assessment. Productivity and construction data are collected from a specialized company in such type of forms. A bracket productivity model has been developed to estimate floor construction cycle time and productivity.

Findings
– Results show that average productivity is four days/floor. The developed model is validated, which shows robust results 97.80 percent.

Research limitations/implications
– The implementation of the developed models are limited to only two projects. However, the developed models and framework is sound for future improvement.

Practical implications
– The developed methodology and model play essential roles in decision-making process.

Originality/value
– The developed methodology and model are beneficial to researchers, practitioners, and planners of construction projects. It provides practitioners with charts that assist in scheduling and managing resources for jump form application. In addition, it provides researchers with a floor cycle time model and framework of implementing jump forms to high-rise buildings.
Improving construction management practice with the Last Planner System: a case study
Authors: O. AlSehaimi Abdullah , Tzortzopoulos Fazenda Patricia , Koskela Lauri 
Published: January 2014

Purpose– The purpose of this paper is to evaluate the effectiveness of implementing the Last Planner System (LPS) to improve construction planning practice and enhance site management in the Saudi construction industry.Design/methodology/approach– LPS was implemented in two large state-owned construction projects through an action research process. The data collection methods included interviews, observations and a survey questionnaire.Findings– The findings identify benefits including improved construction planning, enhanced site management and better communication and coordination between the parties involved. The paper describes the critical success factors for LPS implementation. The paper also describes barriers to the realisation the full potential of LPS, including the involvement of many subcontractors and people's commitment and attitude to time.Research limitations/implications– The work reported in this paper is limited to two case studies.Practical implications– The study has thus contributed to improving management practice and may aid the establishment of a basis for the development of further research in the area of lean construction. The research outcomes can inform practitioners of the opportunity to implement alternative management methods in construction, and give a good account of the opportunities and challenges. Beside the direct benefits to managerial practice, the study also contributed to practice by offering practical recommendation that can assist in the achievement of the full potential of lean and LPS in Saudi Arabia.Originality/value– This is the first comprehensive academic study in the Saudi construction sector concerning the application of lean construction principles and techniques. The study has thus contributed to practice and developed a basis for the development of further research in the area of lean construction. It may help construction organisations to establish a new strategy and policies to improve their managerial practice. The outcomes of the case studies can be used as a reference for organisations seeking to improve their managerial practice.