bluuebunny/crossref_metadata_2025_split huggingface dataset:
ASSESSING DAILY INTAKE OF INDOOR AIR POLLUTANTS FROM 3D PRINTING
Authors: Laicāns Ivars , Ķibilda Elīza , Žvagiņa Krista , Martinsone Žanna , Pavlovska Ilona 
Published: July 2024

The scientific community is increasingly focusing on indoor air quality (IAQ) more than ever, driven by on-going research and fresh perspectives including development of 3D technologies. Exposure dose (EDa) resulting from inhalation of indoor air pollutants emitted by 3D printers were calculated in this study. The consideration of emissions from 3D printers is based on experimental data, primarily sourced from reviewed literature. However, this research also includes some experimental values, excluding the background levels of these pollutants. Experiments were conducted using several 3D printers available (Zortrax M300 Dual) to compare the indoor air pollutants generated and their concentrations with information gathered from earlier research. In the experiments, filaments containing ABS (acrylonitrile, butadiene, and styrene copolymer material, commonly used for 3D printing) were utilized. EDa values of styrene, toluene, formaldehyde, and acetaldehyde for 8-hour and 12-hour shifts for average and maximal (reported) concentrations were calculated based on the available experimental and literature data. The average concentrations of these pollutants were determined by calculating the arithmetic mean, which incorporated concentration values obtained from previous research and experimental data collected within this study. It was concluded that further investigation should focus on aerial concentrations of styrene generated during 3D printing. Calculated EDa for styrene from several studies exceeded the recommended guidelines for Tolerable Daily Intake (TDI) set by the World Health Organization (WHO) by at least 35%. Further exploration is imperative to incorporate additional pathways of indoor air pollutant exposure, such as skin contact and ingestion. This comprehensive approach will provide a more thorough understanding of the overall health risks associated with indoor air quality during 3D printing.
Sociedade em Rede: o Impacto da Cibercultura na Educação a Distância
Authors: Santos Ciro , Pimenta Elane Cristina Lopes Soares , Paula Simone Grace de , Santos Andreia Teixeira de Oliveira 
Published: July 2024

A sociedade contemporânea enfrenta transformações profundas, destacando-se as questões culturais e étnicas. A cibercultura acelera a importância crucial da Educação a Distância na educação superior. Os avanços tecnológicos impulsionam a EAD, moldando metodologias e mídias. Educadores constroem habilidades e competências na formação pedagógica atual. Este trabalho busca oferecer uma visão aprofundada dos desafios que a sociedade contemporânea enfrenta ao incorporar e aproveitar as novas tecnologias no cenário educacional e cultural. Esta pesquisa é guiada por uma revisão meticulosa da literatura científica, empregando uma abordagem qualitativa e fundamentada em uma perspectiva exploratória. Os resultados ressaltam a importância da cibercultura e das inovações tecnológicas, incluindo algoritmos de inteligência artificial, na interação aluno-professor mediada por tutores. Esses elementos são cruciais para garantir qualidade, efetividade e sucesso em cursos a distância.

Palavras-chave: Cibercultura. Educação a distância. Prática pedagógica. Algoritmos genéticos. Aprendizagem de máquina.
Makna Pengkhususan pada QS. al-Baqarah Ayat 256: Analisis Semiotika Charles Sanders
Authors: Yuviandze Bafri Zulliandi  
Published: July 2024

This document analyzes the meaning of specialization in QS. al-Baqarah verse 256 on religious freedom using the semiotic framework of Charles Sanders Peirce. The author explains that Peirce's epistemology is built on four pillars: fallicanism, positive social encouragement, idealistic objectivity, and pragmatism. Peirce also developed the concepts of trichotomy and tripartity in analytic logic, which showed the existence of a set of three interrelated meanings in interpretation. In QS. al-Baqarah verse 256, there is a debate about the concept of religious freedom. Some scholars argue that there is no absolute freedom to change religions. The author of the article tries to analyze the specialization in the verse using 10 signs of Peirce's triadic sign, namely: rheme-icon-qualisign, rheme-icon-sinsign, rheme-index-sinsign, and so on. The analysis of the specialized meaning in verse 256 of QS. al-Baqarah using the semiotic approach of Charles Sanders Peirce reveals ambiguity in the interpretation and application of this verse. The verse emphasizes the absence of compulsion in religion and the clear distinction between the right path and the wrong path. The concept of religious freedom is examined through Peirce's triadic approach, which helps to understand the complexity in the inter-pretation of religion.
Automatic Classification of Sleep-Wake States of Newborns Using Only Body and Face Videos
Authors: Ito Yuki , Morita Kento , Matsumoto Asami , Shinkoda Harumi , Wakabayashi Tetsushi 
Published: July 2024

The premature newborn receives specialized medical care in the neonatal intensive care unit (NICU), where various medical devices emit excessive light and sound stimulation, and those prolonged exposures to stimuli may cause stress and hinder the development of the newborn’s nervous system. The formation of their biological clock or circadian rhythm, influenced by light and sound, is crucial for establishing sleep patterns.	Therefore, it is essential to investigate how the NICU environment affects a newborn’s sleep quality and rhythms. Brazelton’s classification criteria measure the sleep-wake state of newborns, but the visual classification is time-consuming. Therefore, we propose a method to reduce the burden by automatically classifying the sleep-wake state of newborns from video images.	We focused on videos of whole-body and face-only videos of newborns and classified them into five states according to Brazelton’s classification criteria. In this paper, we propose and compare methods of classifying whole-body and face-only videos separately using a three-dimensional convolutional neural network (3D CNN) and combining the two results obtained from whole-body and face-only videos with time-series smoothing.	Experiments using 16 videos of 8 newborn subjects showed that the highest accuracy of 0.611 and kappa score of 0.623 were achieved by weighting the time-series smoothed results from whole-body and face-only videos by the output probabilities from the 3D CNN. This result indicated that the time-series smoothing and combining the results based on probabilities is effective.
Delayed Achilles Tendon Rupture at 17 Years of Age After Treatment of Clubfoot with Ponseti Method
Authors: Wako Masanori , Ichikawa Jiro , Fujimaki Taro , Hagino Tetsuo , Haro Hirotaka 
Published: July 2024

Case:Traumatic pediatric Achilles ruptures are rare, and few cases have been reported among patients with a history of Achilles tenotomy. A 17-year-old boy with a history of Achilles tenotomies for congenital clubfoot as an infant presented with acute midsubstance Achilles tendon rupture of the right leg. The gastrocnemius fascia was dissected to allow for approximation of the ruptured Achilles tendon segments. Furthermore, the plantaris tendon was harvested and sutured around the Achilles tendon-rupture site to improve strength.Conclusions:Patients with a history of clubfoot and chronic Achilles tendon pain should be alerted to the risk of Achilles tendon rupture.
Topological Indices and QSPR/QSAR Analysis of Some Drugs Being Investigated for the Treatment of Alzheimer's Disease Patients
Authors: H Mohammed Yasin H , M Suresh , Bayati Jalal Hatem Hussein 
Published: July 2024

يعد تحليل العلاقات الكمية بين البنية والممتلكات/النشاط (QSPR/QSAR) أمرًا بالغ الأهمية لفهم خصائص المركبات المرتبطة بالمخدرات، خاصة في علاج مرض الزهايمر. في هذه الدراسة، هدفنا هو استخدام أساليب مبتكرة بما في ذلك استخدام المؤشرات الطوبولوجية -درجة و- درجة ، المستمدة من نظرية الرسم البياني، لتقييم الخصائص والخصائص الفيزيائية والكيميائية لخمسة أدوية لمرض الزهايمر: تاكرين، دونيبيزيل، ريفيستيجمين، جالانتامين و والهوبرزين أ . تقدم هذه المؤشرات الطوبولوجية طريقة جديدة لالتقاط المعلومات الهيكلية الجزيئية الأساسية، مما يقلل من عدد الواصفات مع تعزيز ارتباطها بالخصائص الجزيئية المتنوعة. ومن خلال الحسابات الشاملة لهذه المؤشرات، هدفنا هو توضيح الخصائص الجزيئية المعقدة لأدوية مرض الزهايمر. علاوة على ذلك، أجرينا تحليلات QSPR وQSAR لربط المؤشرات الطوبولوجية المحسوبة بالخصائص الفيزيائية والكيميائية المختلفة للأدوية. في حين أن الأساليب المبتكرة المستخدمة في دراستنا توفر رؤى قيمة. لا تساهم النتائج التي توصلنا إليها في تعزيز فهمنا لخصائص أدوية مرض الزهايمر فحسب، بل تحمل أيضًا آثارًا على تطوير الأدوية وتحسينها في إدارة مرض الزهايمر. ومن خلال تعزيز معرفتنا بخصائص هذه المركبات، فإن هدفنا هو معالجة الطبيعة المتعددة العوامل لمرض الزهايمر وتحسين التدخلات العلاجية.
Synthesis, Characterization, and Thermal Studying of VO(II), Cu(II), Zn (II), Cd(II), and Au (III) Complexes with Azo Dye and Evaluation as Antioxidants
Authors: Malek Fadhel Areeg , Ali Salih Al-Hamdani Abbas , Al Zoubi Wail 
Published: July 2024

حضرت معقدات كل من الفنادايل, الخارصين, النحاس والكادميوم بتكافؤهم الثنائي والذهب بتكافؤه الثلاثي بأستخدام صبغة ازوجديدة (6،4،2-ثلاثي هيدروكسي-3-((3-هيدروكسي فنيل) ثنائي زينيل ) فنيل ) ايثان-1-اون المحضرة من ملح الديازونيوم مع ٦,٤,٢- ثلاثي هيدروكسي اسيتوفينون بعد عزل (E)-1-(2,4,6-trihydroxy-3-((3-hydroxyphenyl)diazenyl)phenyl)ethan-1-one تم تشخيصها بواسطة الطرق الطيفية المتاحة والتقنيات التشخيصية لكل من التحليل الدقيق للعناصرواطياف كل من الكتلة ,الرنين النووي البروتوني والكاربوني ,الاشعة فوق البنفسجية ,الاشعة تحت الحمراءومنحنى التحلل الحراري الوزني والمسعر التفاضلي والمعقدات شملت التقنيات هذه فضلا عن تحديد نسبة الفلز وتحديد محتوى الكلور والحساسية المغناطيسية والتوصيلية المولارية. أعطت النتائج أن الليكاند ايوني (سالب) رباعي السن مرة عند تناسقه مع النحاس والخارصين والكادميوم عن طريق ذرة الاوكسجين الفينولية و ذرة الاوكسجين الكاربونيلية وذرة نتروجين الازو , بينما كان ثلاثي السن عند التناسق مع الذهب الثلاثي من خلال ذرة الاوكسجين الفينولية وذرة نتروجين الازو حيث اعطى الذهب شكل مربع مستوي متعادل بينما الخارصين والكادميوم ثماني السطوح متعادل حاوي على جزيئتين ماء متناسقة واعطى النحاس شكل رباعي السطوح متعادل اما الفنادايل فاعطى شكلا ثنائي الهرم المثلثي متعادل. ثم تم تحديد قابلية هذه المركبات المحضرة كمضادات اكسدة من خلال كبحها للجذور الحرة باستعمال مادة DPPH كجذر حر وفيتامين C كمرجع لتحديد قيمة IC50التي اعطت النتائج(Au-complex >H4L>Ascorbic acid > Zn-complex> Cu-complex> Cd-complex>V-complex)
Synthesis, Identification, and Biological Evaluation of new coumarin-pyrazoline Derivatives as Anti-oxidant Agents
Authors: Yusuf Khalaf Wafaa , Abdulredha Raheem Leaqaa , Sabah Elias Youssef Rita 
Published: July 2024

تم تهجين مركب الكومارين مع جزيء غير متجانس يحتوي على النيتروجين يعرف باسم بيرازولين وذلك لزيادة نشاطه البيولوجي، وأظهر نطاقا واسعا من النشاط. تضمنت الدراسة تحضير مركب جديد بطريقة التكثيف، وتم تشخيصها وأثبات الهياكل التركيبية للمركبات المحضرة بمطيافية الاشعة تحت الحمراء، بروتون ن م ر ومطيافية كاربون-13 بالاضافة الى مطيافية الكتلة (, FT-IR 1HNMR، MS, 13CNMR, (والتي اثبت من خلالهما تكون حلقة البيرلزوين من خلال ظهور بروتونات مجموعة المثيلين في ثوابت ازدواج مختلفة. من ناحية اخرى بروتون C11’ ,يتكيف مع زاويتين متجاورتين مختلفتين لبروتوني مجموعة المثيلين , فعليه ان ثابت ازدواج البروتونات المتجاورة مع بعضها البعض اعلى منها لبروتونات المجاورة لبعضها البعض ويمكن للزاوية الثنائية الاتجاه بين البروتونات ترتبط بعلاقة كاربلس مع ثابت ازدواج البروتونات المتجاورة. كما تمت دراسة النشاط الحيوي للمركبات المحضرة باستخدام مبدأ مقايسة ABTS•+ والذي اعتمد على توليد كروموفور الاخضر/ المزرق من خلال التفاعل بين ABTS وبيرسلفات البوتاسيوم عند حوالي 734 نانومتر، حيث أظهرت النتائج أن مشتقات الكومارين- بيرازولين تتميز بنشاط مضاد للأكسدة عالي يتفوق على نشاط حامض الأسكوربيك، وخاصة مشتق ثنائي مثيل أمين .
Pengembangan LKPD POE Berbasis Scientific Literacy untuk Meningkatkan Kemampuan Menulis Ilmiah Peserta Didik
Authors: Rofiah Anisaatur , Faizah Ulinnuha Nur 
Published: July 2024

Pembelajaran IPA dengan menggunakan keterampilan Abad 21 mengharuskan siswa terlibat aktif saat pembelajaran. Pembelajaran IPA pasti erat hubungannya dengan penyelidikan ilmiah, hipotesis, serta kepenulisan dari hasil penyelidikan tersebut. Tujuan dari penelitian ini adalah untuk mengetahui (1) validitas (2) kepraktisan (3) efektivitas. Adapun penelitian ini dirancang dengan metode R&D dengan model pengembangan ADDIE. Pengambilan data dilakukan dengan lembar validasi ahli, lembar angket kepraktisan, dan soal tes. Adapun lokasi penelitian di SMP Negeri 1 Siman. Teknik pengambilan sampel dilakukan dengan menggunakan purposive sampling. Sampel berjumlah 59 peserta didik kelas IX B sebagai kelas kontrol dan IX C sebagai kelas eksperimen. Data yang dihasilkan kemudian di analisis menggunakan uji validasi, uji kepraktisan, tes kemampuan menulis ilmiah, uji two tailed, uji one tailed, uji ancova, dan uji N-gain. Berdasarkan penelitian didapatkan hasil bahwa LKPD POE berbasis scientific literacy dinyatakan (1) sangat valid mendapatkan persentase 94.5% (2) sangat praktis dengan persentase 100% (3) efektif melalui uji two tailed dengan hasil 0.00<0.005 H0 ditolak maka terdapat perbedaan kemampuan menulis kelas eksperimen dan kontrol. Uji one tailed dengan hasil 0.00<0.05 H0 ditolak maka terdapat peningkatan kemampuan menulis ilmiah siswa. Uji ancova mendapatkan hasil 0.00<0.05 maka dinyatakan terdapat perbedaan yang signifikan yang mempengaruhi hasil pre test dan post test kelas eksperimen dan kontrol. N-gain, pada uji N-gain mendapatkan hasil 61.26 dengan kategori sedang.
Dysregulation of N-terminal acetylation causes cardiac arrhythmia and cardiomyopathy
Authors: bezzerides Vassilios , Yoshinaga Daisuke , Feng Rui , Prondzynski Maksymilian , Shani Kevin , Tharani Yashasvi , Mayourian Joshua , Joseph Milosh , Walker David , Bortolin Raul , Carreon Chrystalle , Boss Bridget , Upton Shelia , Parker Kevin , Pu William 
Published: July 2024

Abstract

N-terminal-acetyltransferases including NAA10 catalyze N-terminal acetylation (Nt-acetylation), an evolutionarily conserved co-translational modification. Little is known about the role of Nt-acetylation in cardiac homeostasis. To gain insights, we studied a novel NAA10 variant (p.R4S) segregating with QT-prolongation, cardiomyopathy and developmental delay in a large kindred. Here we show that the NAA10-R4S mutation reduced enzymatic activity, decreased expression levels of NAA10/NAA15 proteins, and destabilized the enzymatic complex NatA. In NAA10R4S/Y-iPSC-CMs, dysregulation of the late sodium and slow rectifying potassium currents caused severe repolarization abnormalities, consistent with clinical QT prolongation. Engineered heart tissues generated from NAA10R4S/Y-iPSC-CMs had significantly decreased contractile force and sarcomeric disorganization, consistent with the pedigree’s cardiomyopathic phenotype. We identified small molecule and genetic therapies that normalized the phenotype of NAA10R4S/Y-iPSC-CMs. Our study defines novel roles of Nt-acetylation in cardiac regulation and delineates mechanisms underlying QT prolongation, arrhythmia, and cardiomyopathy caused by NAA10 dysfunction.
Vaccine Effectiveness Of Bivalent HPV Vaccination Against Genital HPV Of A Catch-Up Campaign And 12 Years Routine Vaccination For Girls-Only: A Biennial Repeated Cross-Sectional Study
Authors: Kusters Johannes MA , Loeff Maarten F Schim , Benthem Birgit HB , King Audrey J , Melker Hester E , Heijman Titia , Heijne Janneke CM 
Published: July 2024

Abstract

Background
The Netherlands is one of few countries worldwide which has used the bivalent HPV vaccine for girls-only for over a decade. This allows assessment of vaccine effectiveness (VE) against female genital HPV DNA-positivity of this vaccine in an observational post-licensing real-world setting. Additionally, it is unclear whether catch-up vaccination campaigns result in similar VE as routine vaccination. Therefore, type-specific and grouped VE were assessed and compared for women who had been eligible for catch-up vaccination at 13–16 years with those who had been eligible for routine vaccination at 12 years.
Methods
PASSYON is a Dutch biennial repeated cross-sectional (2011-21) study among sexual health clinic clients aged 16–24 years old. Women provided self-collected vaginal samples, questionnaires on demographics and sexual behaviour were administered, and women self-reported HPV vaccination status. Samples were analysed using a PCR-based assay (SPF10-LiPA25). Type-specific and grouped VE estimates, adjusted with propensity score stratification, were assessed against genital positivity for 14 HPV-types. VE for targeted and non-targeted genotypes were compared between women who had been eligible for the catch-up and those who had been eligible for routine vaccination.
Results
The study included 4,488 female participants who had been eligible for HPV vaccination and provided genital swabs (1,561 eligible for catch-up, 2,927 for routine vaccination). Very high VE against genital HPV-16 and HPV-18 was observed (resp. 93.5% and 89.5%) and significant cross-protection against six other genotypes (HPV-31/33/35/45/52/58), varying from 18.0% (HPV-52) to 79.6% (HPV-45). VE estimates were comparable between women who had been eligible for the catch-up campaign and those eligible for routine vaccination: VE HPV-16/18: 92.2% (95%CI: 87.9–94.9) vs. 91.8% (95%CI: 86.0-95.2).
Conclusions
In real-world settings, the VE of bivalent vaccine is high against targeted genotypes, with cross-protection against 6 other genotypes. Catch-up campaigns up to age 16 years can be as effective as routine vaccination at age 12. This may inform countries considering catch-up campaigns when introducing or extending the use of HPV vaccination within their national immunisation programmes.
Intraoperative central venous pressures related to early graft function in deceased donor kidney transplant recipients with low immunological risks
Authors: Ahn Hyoeun , Bang Jun Bae 
Published: July 2024

Abstract

This study aims to analyze data from patients who received kidney transplantation from deceased donors to investigate the anesthetic factors influencing early and late graft outcomes, including the incidence of slow graft function (SGF), delayed graft function (DGF), and 3-year graft outcomes. We retrospectively analyzed 202 recipients who underwent deceased donor kidney transplantation from March 2010 to December 2020. Anesthetic monitoring data during the intraoperative period was analyzed at 5-minute intervals, and basic clinical parameters were evaluated. The mean recipient age was 46.6 ± 10.3 years, and the mean donor age was 41.7 ± 12.7 years. Anesthetic time averaged 285.8 ± 70.2 minutes, and operation time averaged 223.1 ± 44.0 minutes. The incidence of SGF was 11.8%, and the incidence of DGF was 3.9%. Mean central venous pressures (CVPs) were higher in recipients with SGF or DGF (11.7 mmHg) compared to those with immediate graft function (9.7 mmHg). Higher CVP was identified as an independent risk factor for SGF or DGF (odds ratio 1.219, p = 0.006). This study suggests that intraoperative monitoring of CVP is crucial for predicting short-term graft function in deceased donor kidney transplantation and should be managed to prevent excessive fluid intake.
Assessing the Efficacy and Safety of Ivermectin use for Lymphatic Filariasis Among Eligible Civil Servants in Kaduna State
Authors: Ashaolu Joseph Opeolu , Salisu Umar 
Published: July 2024

Abstract

Background: Lymphatic filariasis (LF) is a parasitic disease transmitted through mosquito bites, causing debilitating symptoms such as lymphedema and elephantiasis. Ivermectin has shown promises in treating various parasitic infections, including lymphatic filariasis. However, its efficacy and safety profile, especially among civil/public servants remain understudied. This study aims to evaluate the effectiveness and safety of Ivermectin in treating Lymphatic filariasis among eligible civil servants in Kaduna State, Nigeria.
Method: The research study employed a mixed-methods approach, combining quantitative data on treatment outcomes and qualitative insights on the experiences of participants. The study also assessed the impact of Ivermectin treatment on the quality of life and productivity of study participants. The hypothesis for this study was tested using chi-square analyses.
Result: Our study showed that age, gender and duration of service are the factors statistically significant (P<0.05) with the prevalence of LF, suggesting possible socio-demographic factors for LF. However, age and gender were the only significant variables (P<0.05) associated with Ivermectin administration and its safety profile among eligible civil servants of Kaduna State. Findings from this study indicates that 71% (n=230) of the total sample have ever taken Ivermectin for LF, in contrast to 29% (n=93) who have never taken Ivermectin for LF. More so, 59% (n=189) of the total sample were aware of the potential side effects of Ivermectin. 98% (n=316) who have taken Ivermectin reported not to have experienced any side effects taking this medication for LF, coupled with 65%, (n=209) who reported that Ivermectin effected an improvement in their LF symptoms. In addition, 83% (n=269) of the respondent suggested that Ivermectin should be publicly made available in the community for end-users. Similarly, 69% (n=224) respondents are aware of some contraindications associated with the use of Ivermectin. Despite this, 80% (n=259) reported never to have missed their treatment which may indicate that the knowledge of contraindication does not necessarily equate avoidance of treatment with Ivermectin. 71% (n=228) admitted that they have a feeling of adequacy of the dose regimen being administered to them, while 82% (n=266) registered their satisfaction with the effectiveness of Ivermectin for LF treatment.
Conclusion: Our study shows that Ivermectin, to a very large extent, is well accepted among the populace for LF treatment. However, additional effort must be put in place to educating the not yet adhering population at risk of the infection. Campaigns to take and adhere to the administration protocol of the medication is essential since the goal is elimination of the infection in the community. Safety monitoring in those with chronic manifestation of LF during MDA is also recommended for proper management
Accurate Protein-Ligand Binding Free Energy Estimation by Applying QM/MM Calculations on Multi-Conformers Predicted from a Classical Mining Minima Approach
Authors: Cho Art , Molani Farzad 
Published: July 2024

Abstract

In a bid to develop a more accurate binding free energy prediction method that is becoming ever more important in drug discovery, we have concocted four protocols that combine QM/MM calculations and the mining minima method. We tested these protocols on 9 targets and 203 ligands. Our protocols carry out free energy processing with or without conformational search on the selected conformers obtained from classical VM2 calculations, where their force field atomic charge parameters are substituted with those obtained from a QM/MM calculation. The free energy processing with or without conformational search takes an average of 15 minutes or 1 minute per conformer, respectively. A reasonably high Pearson’s correlation coefficient (0.69) was achieved in relation to experimental binding free energies across a broad range of targets, demonstrating the generality of the method. Our proposed differential evolution algorithm, with a universal scaling factor of 0.2, achieved a low mean absolute error (MAE) of 0.60. This correlation and MAE are noticeably better than many common methods and comparable with most popular relative binding free energy (RBFE) methods. Meanwhile, the computing cost of our protocol is significantly lower than any of them. Moreover, our method gives binding poses of local minima, which can be further exploited for protein-ligand interactions analysis.