bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Nonsensical is our thing!’: Queering fanservice as ‘Deleuzional’ desire-production in Studio Trigger’s Kiru ra Kiru/Kill la Kill
Authors: Boyd David John 
Published: November 2015

Abstract
This article seeks to investigate the revolutionary and queer possibilities in contemporary Japanese media and the otaku subculture. By specifically re-evaluating the aesthetic practice of fanservice in otaku media, it further reimagines fanservice as an aesthetically and philosophically productive model for reanimating political and sexual politics of resistance to hetero/homonormative capitalism. Relying primarily on Deleuzian media theory, this reading utilizes Studio Trigger’s smash hit animation Kiru ra Kiru/Kill la Kill (Imaishi, 2013–14) as a case study for the transformative potential of queering sexual-political assemblages within the re-engineered circuits and networks of otaku desire. This series further enunciates an upheaval of traditional discourses pertaining to gender representation and perversion in otaku media through its rhizomatic web of desiring-images that explores queer performativity, politicized desire-production and a collectivist strategy of binding together coalitions of dynamically intense desires into a new queer-otaku assemblage.
Emptying the future: Queer melodramatics and negative utopia in Buffy the Vampire Slayer
Authors: Keegan Cael M. 
Published: November 2015

Abstract
Why should we still care about Buffy the Vampire Slayer (1997–2003, WB/UPN)? With more than two hundred scholarly articles, a yearly conference and an academic journal devoted to its study, Buffy has been well explored. Yet compared to current broadcast programming, the show continues to stand out as an uncommonly radical mainstream text. Since Buffy’s last airing, realist images of the ‘good gay citizen’ have proliferated across US broadcast television, depicting lesbian and gay characters as assimilated extensions of the bourgeois heteronormative family and its consumer practices. In contrast, Buffy offers viewers a melodramatic and queerly negative popular aesthetic of the sort that barely exists today. In this article, therefore, the author returns to Buffy and its darkly queer hero, Willow Rosenberg (played by Alyson Hannigan), as indicators of utopian possibilities forgotten – but hopefully not yet lost.
Environmental factors in migratory route decisions: a case study on Greenlandic Arctic Terns (Sterna paradisaea)
Authors: Hensz Christopher Michael 
Published: November 2015

AbstractIdentification and characterization of seasonal
migration routes and stopover sites has been recognized
as important to the conservation of migratory species.
This project utilizes multiple regression models including
circular-linear regression to identify associations
between route choice, travel speed, and environmental
preferences using trajectory data of migratory Arctic
Terns (Sterna paradisaea) and environmental data
obtained through remote-sensing techniques. Results
of this study suggest that route choice on the southward
post-breeding migration route may be more dependent
on underlying environment than the northward postwintering
migration route. In contrast, travel speed
was variably associated with underlying environment
between southward and northward migrations, including
several differences regarding the impact of interactions
between environmental variables. These results reveal the
importance of using multiple metrics in the estimation
of spatial resistance and highlight conflicts between the
theoretical resistance framework of GIS and movement
analysis methods.
Overview of recent control technologies for future power systems
Authors: Münz Ulrich , Metzger Michael , Szabo Andrei , Reischböck Markus , Steinke Florian , Wolfrum Philipp , Sollacher Rudolf , Obradovic Dragan , Buhl Michael , Lehmann Thomas , Duckheim Mathias , Langemeyer Stefan 
Published: November 2015

Abstract
The increasing integration of renewable power generation in power systems poses new challenges to power system control. In this
article, we describe a multi-layer power system control architecture that addresses these challenges and comprises economic planning,
supervisory power control, as well as voltage and frequency control as main layers. Several parts of this architecture have already
been developed and tested on diverse components including building energy management, micro grid management and wind park control. We
provide an overview of these applications and indicate white spots in this control architecture that require further research.
Loading and dilution: arsenic, sodium and nutrients in a sectionof the River Tisza, Hungary
Authors: Türk Gábor , Prokisch József , Simon Edina , Szabó Szilárd 
Published: November 2015

AbstractWe aimed to reveal the risk of arsenic in a Hungarianriver (the Tisza) at the mouth of a polluted canal.Four sampling sites were involved in this work and sampleswere collected on a weekly basis for arsenic andsodium, and on a monthly basis for nutrients. Significantdifferences were found concerning each studied componentbetween the sampling locations of the River Tisza.Statistical analysis also revealed that the values of the upperand lower river tracts did not differ significantly. Thus,water carried by the canal is being diluted before it reachesthe farthest sampling location.
Geological and engineering analysis of residualsoil for forewarning landslide from highland areain northern Thailand
Authors: Thongkhao Thanakrit , Phantuwongraj Sumet , Choowong Montri , Thitimakorn Thanop , Charusiri Punya 
Published: November 2015

Abstract
One devastating landslide event in northernThailand occurred in 2006 at Ban Nong Pla village, ChiangKlang highland of Nan province after, a massive amountof residual soil moved from upstream to downstream, viacreek tributaries, into a main stream after five days of unusualheavy rainfall. In this paper, the geological and engineeringproperties of residual soil derived fromsedimentaryrocks were analyzed and integrated. Geological mapping,electrical resistivity survey and test pits were carriedout along three transect lines together with systematiccollection of undisturbed and disturbed residual soilsamples. As a result, the average moisture content in soilis 24.83% with average specific gravity of 2.68,whereas theliquid limit is 44.93%, plastic limit is 29.35% and plastic indexis 15.58%. The cohesion of soil ranges between 0.096–1.196 ksc and the angle of internal friction is between 11.51and 35.78 degrees. This suggests that the toughness propertiesof soil change when moisture content increases. Resultsfrom electrical resistivity survey reveal that soil thicknessesabove the bedrock along three transects range from2 to 9 m. The soil shear strength reach the rate of high decreasesin the range of 72 to 95.6% for residual soil fromshale, siltstone and sandstone, respectively. Strength ofsoil decreaseswhen the moisture content in soil increases.Shear strength also decreases when the moisture contentchanges. Therefore, the natural soil slope in the study areawill be stable when the moisture content in soil level isequal to one, but when the moisture content between soilparticle increases, strength of soil will decrease resultingin soil strength decreasing.
A Review of Cloud Computing Bioinformatics Solutions for Next-Gen Sequencing Data Analysis and Research
Authors: Krampis Konstantinos , Wultsch Claudia 
Published: November 2015

Abstract
Research in biology has entered a digital era,
where next-generation sequencing instruments generate
multiple terabytes of data but are equipped with minimal
computational and storage capacity that is not sufficient
for large-scale, post-sequencing data analysis. Therefore,
scientific value cannot be obtained from investment in a
sequencing instrument, unless it is also combined with
a significant expense for informatics infrastructure. An
alternative option for laboratories is to outsource their
informatics infrastructure, by leasing computational
cycles and storage capacity from cloud computing services.
Development of cloud-based bioinformatics tool suites
can provide users with access to pre-configured software
and on-demand computing resources for genomic data
analysis, while at the same time lower the barrier for
working with sequencing datasets, leading to broader
adoption of genomic technologies for basic biological
research. We conclude that along with the democratization
of genome sequencing through the availability of lowcost,
bench-top sequencers, cloud computing can in
turn democratize access to computational capacity and
informatics infrastructures required for sequencing data
analysis.
Decoding Articulatory Features from fMRI Responses in Dorsal Speech Regions
Authors: Correia Joao M. , Jansma Bernadette M.B. , Bonte Milene 
Published: November 2015

The brain's circuitry for perceiving and producing speech may show a notable level of overlap that is crucial for normal development and behavior. The extent to which sensorimotor integration plays a role in speech perception remains highly controversial, however. Methodological constraints related to experimental designs and analysis methods have so far prevented the disentanglement of neural responses to acoustic versus articulatory speech features. Using a passive listening paradigm and multivariate decoding of single-trial fMRI responses to spoken syllables, we investigated brain-based generalization of articulatory features (place and manner of articulation, and voicing) beyond their acoustic (surface) form in adult human listeners. For example, we trained a classifier to discriminate place of articulation within stop syllables (e.g., /pa/ vs /ta/) and tested whether this training generalizes to fricatives (e.g., /fa/ vs /sa/). This novel approach revealed generalization of place and manner of articulation at multiple cortical levels within the dorsal auditory pathway, including auditory, sensorimotor, motor, and somatosensory regions, suggesting the representation of sensorimotor information. Additionally, generalization of voicing included the right anterior superior temporal sulcus associated with the perception of human voices as well as somatosensory regions bilaterally. Our findings highlight the close connection between brain systems for speech perception and production, and in particular, indicate the availability of articulatory codes during passive speech perception.SIGNIFICANCE STATEMENTSensorimotor integration is central to verbal communication and provides a link between auditory signals of speech perception and motor programs of speech production. It remains highly controversial, however, to what extent the brain's speech perception system actively uses articulatory (motor), in addition to acoustic/phonetic, representations. In this study, we examine the role of articulatory representations during passive listening using carefully controlled stimuli (spoken syllables) in combination with multivariate fMRI decoding. Our approach enabled us to disentangle brain responses to acoustic and articulatory speech properties. In particular, it revealed articulatory-specific brain responses of speech at multiple cortical levels, including auditory, sensorimotor, and motor regions, suggesting the representation of sensorimotor information during passive speech perception.
Convergence of Hippocampal Pathophysiology inSyngap+/−andFmr1−/yMice
Authors: Barnes Stephanie A. , Wijetunge Lasani S. , Jackson Adam D. , Katsanevaki Danai , Osterweil Emily K. , Komiyama Noboru H. , Grant Seth G.N. , Bear Mark F. , Nägerl U. Valentin , Kind Peter C. , Wyllie David J.A. 
Published: November 2015

Previous studies have hypothesized that diverse genetic causes of intellectual disability (ID) and autism spectrum disorders (ASDs) converge on common cellular pathways. Testing this hypothesis requires detailed phenotypic analyses of animal models with genetic mutations that accurately reflect those seen in the human condition (i.e., have structural validity) and which produce phenotypes that mirror ID/ASDs (i.e., have face validity). We show that SynGAP haploinsufficiency, which causes ID with co-occurring ASD in humans, mimics and occludes the synaptic pathophysiology associated with deletion of theFmr1gene.Syngap+/−andFmr1−/ymice show increases in basal protein synthesis and metabotropic glutamate receptor (mGluR)-dependent long-term depression that, unlike in their wild-type controls, is independent of new protein synthesis. Basal levels of phosphorylated ERK1/2 are also elevated inSyngap+/−hippocampal slices. Super-resolution microscopy reveals thatSyngap+/−andFmr1−/ymice show nanoscale alterations in dendritic spine morphology that predict an increase in biochemical compartmentalization. Finally, increased basal protein synthesis is rescued by negative regulators of the mGlu subtype 5 receptor and the Ras–ERK1/2 pathway, indicating that therapeutic interventions for fragile X syndrome may benefit patients with SYNGAP1 haploinsufficiency.SIGNIFICANCE STATEMENTAs the genetics of intellectual disability (ID) and autism spectrum disorders (ASDs) are unraveled, a key issue is whether genetically divergent forms of these disorders converge on common biochemical/cellular pathways and hence may be amenable to common therapeutic interventions. This study compares the pathophysiology associated with the loss of fragile X mental retardation protein (FMRP) and haploinsufficiency of synaptic GTPase-activating protein (SynGAP), two prevalent monogenic forms of ID. We show thatSyngap+/−mice phenocopyFmr1−/ymice in the alterations in mGluR-dependent long-term depression, basal protein synthesis, and dendritic spine morphology. Deficits in basal protein synthesis can be rescued by pharmacological interventions that reduce the mGlu5receptor–ERK1/2 signaling pathway, which also rescues the same deficit inFmr1−/ymice. Our findings support the hypothesis that phenotypes associated with genetically diverse forms of ID/ASDs result from alterations in common cellular/biochemical pathways.
GIRK Channels Mediate the Nonphotic Effects of Exogenous Melatonin
Authors: Hablitz Lauren M. , Molzof Hylton E. , Abrahamsson Kathryn E. , Cooper Joanna M. , Prosser Rebecca A. , Gamble Karen L. 
Published: November 2015

Melatonin supplementation has been used as a therapeutic agent for several diseases, yet little is known about the underlying mechanisms by which melatonin synchronizes circadian rhythms. G-protein signaling plays a large role in melatonin-induced phase shifts of locomotor behavior and melatonin receptors activate G-protein-coupled inwardly rectifying potassium (GIRK) channels inXenopusoocytes. The present study tested the hypothesis that melatonin influences circadian phase and electrical activity within the central clock in the suprachiasmatic nucleus (SCN) through GIRK channel activation. Unlike wild-type littermates, GIRK2 knock-out (KO) mice failed to phase advance wheel-running behavior in response to 3 d subcutaneous injections of melatonin in the late day. Moreover,in vitrophase resetting of the SCN circadian clock by melatonin was blocked by coadministration of a GIRK channel antagonist tertiapin-q (TPQ). Loose-patch electrophysiological recordings of SCN neurons revealed a significant reduction in the average action potential rate in response to melatonin. This effect was lost in SCN slices treated with TPQ and SCN slices from GIRK2 KO mice. The melatonin-induced suppression of firing rate corresponded with an increased inward current that was blocked by TPQ. Finally, application of ramelteon, a potent melatonin receptor agonist, significantly decreased firing rate and increased inward current within SCN neurons in a GIRK-dependent manner. These results are the first to show that GIRK channels are necessary for the effects of melatonin and ramelteon within the SCN. This study suggests that GIRK channels may be an alternative therapeutic target for diseases with evidence of circadian disruption, including aberrant melatonin signaling.SIGNIFICANCE STATEMENTDespite the widespread use of melatonin supplementation for the treatment of sleep disruption and other neurological diseases such as epilepsy and depression, no studies have elucidated the molecular mechanisms linking melatonin-induced changes in neuronal activity to its therapeutic effects. Here, we used behavioral and electrophysiological techniques to address this scientific gap. Our results show that melatonin and ramelteon, a potent and clinically relevant melatonin receptor agonist, significantly affect the neurophysiological function of suprachiasmatic nucleus neurons through activation of G-protein-coupled inwardly rectifying potassium (GIRK) channels. Given the importance of GIRK channels for neuronal excitability (with >600 publications on these channels to date), our study should generate broad interest from neuroscientists in fields such as epilepsy, addiction, and cognition.
Protein Phosphatase-1 Inhibitor-2 Is a Novel Memory Suppressor
Authors: Yang Hongtian , Hou Hailong , Pahng Amanda , Gu Hua , Nairn Angus C. , Tang Ya-Ping , Colombo Paul J. , Xia Houhui 
Published: November 2015

Reversible phosphorylation, a fundamental regulatory mechanism required for many biological processes including memory formation, is coordinated by the opposing actions of protein kinases and phosphatases. Type I protein phosphatase (PP1), in particular, has been shown to constrain learning and memory formation. However, how PP1 might be regulated in memory is still not clear. Our previous work has elucidated that PP1 inhibitor-2 (I-2) is an endogenous regulator of PP1 in hippocampal and cortical neurons (Hou et al., 2013). Contrary to expectation, our studies of contextual fear conditioning and novel object recognition in I-2 heterozygous mice suggest that I-2 is a memory suppressor. In addition, lentiviral knock-down of I-2 in the rat dorsal hippocampus facilitated memory for tasks dependent on the hippocampus. Our data indicate that I-2 suppresses memory formation, probably via negatively regulating the phosphorylation of cAMP/calcium response element-binding protein (CREB) at serine 133 and CREB-mediated gene expression in dorsal hippocampus. Surprisingly, the data from both biochemical and behavioral studies suggest that I-2, despite its assumed action as a PP1 inhibitor, is a positive regulator of PP1 function in memory formation.SIGNIFICANCE STATEMENTWe found that inhibitor-2 acts as a memory suppressor through its positive functional influence on type I protein phosphatase (PP1), likely resulting in negative regulation of cAMP/calcium response element-binding protein (CREB) and CREB-activated gene expression. Our studies thus provide an interesting example of a molecule with anin vivofunction that is opposite to itsin vitrofunction. PP1 plays critical roles in many essential physiological functions such as cell mitosis and glucose metabolism in addition to its known role in memory formation. PP1 pharmacological inhibitors would thus not be able to serve as good therapeutic reagents because of its many targets. However, identification of PP1 inhibitor-2 as a critical contributor to suppression of memory formation by PP1 may provide a novel therapeutic target for memory-related diseases.
Examining the Role of the Human Hippocampus in Approach–Avoidance Decision Making Using a Novel Conflict Paradigm and Multivariate Functional Magnetic Resonance Imaging
Authors: O'Neil Edward B. , Newsome Rachel N. , Li Iris H.N. , Thavabalasingam Sathesan , Ito Rutsuko , Lee Andy C.H. 
Published: November 2015

Rodent models of anxiety have implicated the ventral hippocampus in approach–avoidance conflict processing. Few studies have, however, examined whether the human hippocampus plays a similar role. We developed a novel decision-making paradigm to examine neural activity when participants made approach/avoidance decisions under conditions of high or absent approach–avoidance conflict. Critically, our task required participants to learn the associated reward/punishment values of previously neutral stimuli and controlled for mnemonic and spatial processing demands, both important issues given approach–avoidance behavior in humans is less tied to predation and foraging compared to rodents. Participants played a points-based game where they first attempted to maximize their score by determining which of a series of previously neutral image pairs should be approached or avoided. During functional magnetic resonance imaging, participants were then presented with novel pairings of these images. These pairings consisted of images of congruent or opposing learned valences, the latter creating conditions of high approach–avoidance conflict. A data-driven partial least squares multivariate analysis revealed two reliable patterns of activity, each revealing differential activity in the anterior hippocampus, the homolog of the rodent ventral hippocampus. The first was associated with greater hippocampal involvement during trials with high as opposed to no approach–avoidance conflict, regardless of approach or avoidance behavior. The second pattern encompassed greater hippocampal activity in a more anterior aspect during approach compared to avoid responses, for conflict and no-conflict conditions. Multivoxel pattern classification analyses yielded converging findings, underlining a role of the anterior hippocampus in approach–avoidance conflict decision making.SIGNIFICANCE STATEMENTApproach–avoidance conflict has been linked to anxiety and occurs when a stimulus or situation is associated with reward and punishment. Although rodent work has implicated the hippocampus in approach–avoidance conflict processing, there is limited data on whether this role applies to learned, as opposed to innate, incentive values, and whether the human hippocampus plays a similar role. Using functional neuroimaging with a novel decision-making task that controlled for perceptual and mnemonic processing, we found that the human hippocampus was significantly active when approach–avoidance conflict was present for stimuli with learned incentive values. These findings demonstrate a role for the human hippocampus in approach–avoidance decision making that cannot be explained easily by hippocampal-dependent long-term memory or spatial cognition.