bluuebunny/crossref_metadata_2025_split huggingface dataset:
Between aid and rights: Humanitarian international NGOs responding to the crisis of European refugee protection
Authors: Dany Charlotte 
Published: July 2024

AbstractThe ongoing crisis of refugee protection in Europe exemplifies a tension between providing humanitarian aid and fighting for human rights. Some recent studies have been highly critical of humanitarian action in this context, suggesting that giving aid to refugees in Europe is a substitute for and suppression of human rights work (Dittmer and Lorenz 2021a; Cuttitta 2018; Ticktin 2016). However, humanitarian aid comprises both, humanitarianism and human rights. This study investigates how humanitarian international non-governmental organisations (INGOs) have striven to protect refugees from North Africa, the Middle East and Ukraine from 2015 to 2023. During this time, many have established new programs in Europe. A content analysis of documents by four humanitarian INGOs shows how they work to integrate both, aid and rights, in their refugee work. This creates certain tensions. For example, the analysis suggests that localisation is one way to integrate human rights into humanitarian action, however at the risk of compromising humanitarian principles.
The contribution of the University of São Paulo to the scientific production on climate change: a bibliometric analysis
Authors: Diniz Oliveira Thais , dos Santos Tailine Corrêa , Weiler Jéssica , de Oliveira e Aguiar Alexandre , Fernandes Carolina Cristina , Ziglio Luciana 
Published: July 2024

AbstractThis paper evaluates how the contribution of scientific publications on climate change from the University of São Paulo (USP) evolved between 1989 and 2022. The study conducted a bibliometric analysis of 2874 research articles collected from the Web of Science and Scopus databases to explore main trend topics and reveal influential journals and collaboration networks using the Bibliometrix software. The study shows an increasing and more significant temporal publication distribution from 2010 onwards. Based on the author’s affiliations, results indicate that the most important partnerships are national (67%), while the international co-authorships are predominantly with research collaborators of the Global North (North America and Europe). Several papers published in the period are in high-impact factor journals, evidence on climate change from USP. Environmental services, Atlantic Forest, Tropical Forest, Amazon, biodiversity, and Land use are the hotspot research topics to which USP researchers contribute. The evolution of three thematic groups was identified: (i) physical science, (ii) causes and effects, and (iii) strategies, discussed in themes such as organic matter, deforestation, and mitigation, respectively. This research is helpful to get insights into the current research development trends, to show the broadness of the scientific production, and the importance of the USP role in the climate change theme. Ultimately, it provides valuable information for further studies and suggests the possibility of advancing the research agenda on climate change with the Global South.
Graphical Abstract
The role of exposure to nature in perceived stress by veterinary students
Authors: Cruz-Martinez Luis , Hervé-Claude Luis Pablo , Gallagher Chista Ann , Dzikiti Loveness , Little William Brady 
Published: July 2024

AbstractVeterinary school is intense and represents a challenging time for students, and increasingly, veterinary students are being diagnosed with a variety of concerning mental health issues including stress, anxiety, and depression, often resulting in poor academic performance. Because of the disproportionately high risk of mental health problems in the veterinary field, it is important that students learn, understand, and utilize simple and effective techniques to cope with stress, and demands of the profession. Spending time in natural environments such as outdoor parks, green spaces, and urban forests is an effective strategy for improving mental health. In this study, we examined the self-reported effects of repeated, structured time in a nature-based intervention, vs a control group of veterinary students. Participants reported significantly lower perceived stress levels compared to a control group. Students overwhelmingly reported that they would recommend this stress reduction technique to their classmates, and they stated that they planned to continue spending time in nature to improve their mindset and reduce stress in the future.
Controls on Stable Methane Isotope Values in Northern Peatlands and Potential Shifts in Values Under Permafrost Thaw Scenarios
Authors: Kuhn McKenzie A. , Varner Ruth K. , McCalley Carmody K. , Perryman Clarice R. , Aurela Mika , Burke Sophia A. , Chanton Jeffrey P. , Crill Patrick M. , DelGreco Jessica , Deng Jia , Heffernan Liam , Herrick Christina , Hodgkins Suzanne B. , Jones Cheristy P. , Juutinen Sari , Kane Evan S. , Lamit Louis J. , Larmola Tuula , Lilleskov Erik , Olefeldt David , Palace Michael W. , Rich Virginia I. , Schulze Christopher , Shorter Joanne H. , Sullivan Franklin B. , Sonnentag Oliver , Turetsky Merritt R. , Waldrop Mark P. 
Published: July 2024

AbstractNorthern peatlands are a globally significant source of methane (CH4), and emissions are projected to increase due to warming and permafrost loss. Understanding the microbial mechanisms behind patterns in CH4 production in peatlands will be key to predicting annual emissions changes, with stable carbon isotopes (δ13C‐CH4) being a powerful tool for characterizing these drivers. Given that δ13C‐CH4 is used in top‐down atmospheric inversion models to partition sources, our ability to model CH4 production pathways and associated δ13C‐CH4 values is critical. We sought to characterize the role of environmental conditions, including hydrologic and vegetation patterns associated with permafrost thaw, on δ13C‐CH4 values from high‐latitude peatlands. We measured porewater and emitted CH4 stable isotopes, pH, and vegetation composition from five boreal‐Arctic peatlands. Porewater δ13C‐CH4 was strongly associated with peatland type, with δ13C enriched values obtained from more minerotrophic fens (−61.2 ± 9.1‰) compared to permafrost‐free bogs (−74.1 ± 9.4‰) and raised permafrost bogs (−81.6 ± 11.5‰). Variation in porewater δ13C‐CH4 was best explained by sedge cover, CH4 concentration, and the interactive effect of peatland type and pH (r2 = 0.50, p < 0.001). Emitted δ13C‐CH4 varied greatly but was positively correlated with porewater δ13C‐CH4. We calculated a mixed atmospheric δ13C‐CH4 value for northern peatlands of −65.3 ± 7‰ and show that this value is more sensitive to landscape drying than wetting under permafrost thaw scenarios. Our results suggest northern peatland δ13C‐CH4 values are likely to shift in the future which has important implications for source partitioning in atmospheric inversion models.
Plume‐Driven Subduction Termination in 3‐D Mantle Convection Models
Authors: Heilman Erin , Becker Thorsten W. 
Published: July 2024

AbstractThe effect of mantle plumes is secondary to that of subducting slabs for modern plate tectonics when considering plate driving forces. However, the impact of plumes on tectonics and planetary surface evolution may nonetheless have been significant. We use numerical mantle convection models in a 3‐D spherical chunk geometry with damage rheology to study some of the dynamics of plume‐slab interactions. Substantiating our earlier 2‐D results, we observe a range of interaction scenarios, and that the plume‐driven subduction terminations we had identified earlier persist in more realistic convective flow. We analyze the dynamics of plume affected subduction, including in terms of their geometry, frequency, and the overall effect of plumes on surface dynamics as a function of the fraction of internal to bottom heating. Some versions of such plume‐slab interplay may be relevant for geologic events, for example, for the inferred ∼183 Ma Karoo large igneous province formation and associated slab disruption. More recent examples may include the impingement of the Afar plume underneath Africa leading to disruption of the Hellenic slab, and the current complex structure imaged for the subduction of the Nazca plate under South America. Our results imply that plumes may play a significant role not just in kick‐starting plate tectonics, but also in major modifications of slab‐driven plate motions, including for the present‐day mantle.
IDH1-mutant metabolite D-2-hydroxyglutarate inhibits proliferation and sensitizes glioma to temozolomide via down-regulating ITGB4/PI3K/AKT
Authors: Tong Shuangmei , Wu Jian , Song Yun , Fu Wenhuan , Yuan Yifan , Zhong Pin , Liu Yinlong , Wang Bin 
Published: July 2024

AbstractThe heterogeneous molecular subtypes of gliomas demonstrate varied responses to chemotherapy and distinct prognostic outcomes. Gliomas with Isocitrate dehydrogenase 1 (IDH1) mutation are associated with better outcomes and are more responsive to temozolomide (TMZ) compared to those without IDH1 mutation. IDH1-mutant gliomas elevate D-2-hydroxyglutarate (D-2HG) levels, with potential dual effects on tumor progression. Limited research has explored the potential anti-glioma effects of D-2HG in combination with TMZ. Clinical data from over 2500 glioma patients in our study confirms that those with IDH1 mutations exhibit enhanced responsiveness to TMZ chemotherapy and a significantly better prognosis compared to IDH1 wild-type patients. In subsequent cellular experiments, we found that the IDH1-mutant metabolite D-2HG suppresses Integrin subunit beta 4 (ITGB4) expression, and down-regulate the phosphorylation levels of PI3K and AKT, ultimately inhibiting cell proliferation while promoting apoptosis, thereby improving glioma prognosis. Additionally, we have demonstrated the synergistic effect of D-2HG and TMZ in anti-glioma therapy involved inhibiting the proliferation of glioma cells and promoting apoptosis. Finally, by integrating data from the CGGA and TCGA databases, it was validated that ITGB4 expression was lower in IDH1-mutant gliomas, and patients with lower ITGB4 expression were associated with better prognosis. These findings indicate that ITGB4 may be a promising therapeutic target for gliomas and D-2HG inhibits proliferation and sensitizes glioma to temozolomide via down-regulating ITGB4/PI3K/AKT. These findings drive theoretical innovation and research progress in glioma therapy.
Flexible multitask computation in recurrent networks utilizes shared dynamical motifs
Authors: Driscoll Laura N. , Shenoy Krishna , Sussillo David 
Published: July 2024

AbstractFlexible computation is a hallmark of intelligent behavior. However, little is known about how neural networks contextually reconfigure for different computations. In the present work, we identified an algorithmic neural substrate for modular computation through the study of multitasking artificial recurrent neural networks. Dynamical systems analyses revealed learned computational strategies mirroring the modular subtask structure of the training task set. Dynamical motifs, which are recurring patterns of neural activity that implement specific computations through dynamics, such as attractors, decision boundaries and rotations, were reused across tasks. For example, tasks requiring memory of a continuous circular variable repurposed the same ring attractor. We showed that dynamical motifs were implemented by clusters of units when the unit activation function was restricted to be positive. Cluster lesions caused modular performance deficits. Motifs were reconfigured for fast transfer learning after an initial phase of learning. This work establishes dynamical motifs as a fundamental unit of compositional computation, intermediate between neuron and network. As whole-brain studies simultaneously record activity from multiple specialized systems, the dynamical motif framework will guide questions about specialization and generalization.
Solution processed high aspect ratio ultra-long vertically well-aligned ZnO nano scintillators for potential X-ray imaging applications
Authors: Kurudirek Sinem V. , Kurudirek Murat , Erickson Anna , Hertel Nolan , Sellin Paul J. , Tratsiak Yauhen , Lawrie Benjamin J. , Melcher Charles L. , Summers Christopher J. 
Published: July 2024

AbstractWe report the photon (PL), electron (CL) and X-ray (XEL) induced luminescence characteristics of high aspect ratio ultra-long (~ 50 µm) ZnO nanorods (NRs) and discuss the potential for fast X-ray detection based on the consistent and efficient visible emission (~ 580 nm) from ZnO NRs. Nanostructured ZnO scintillators were rearranged to form a vertically well-aligned NR design in order to help light absorption and coupling resulting in luminescent and fast scintillation properties. The design of the nanorod array combines the key advantages of a low-cost growth technique together with environmentally friendly and widely available materials. A low temperature hydrothermal method was adopted to grow ZnO NRs in one cycle growth and their structural, optical and X-ray scintillation properties were investigated. The relatively short (~ 10 µm) ZnO NRs emitting in the near-band-edge region were found to be almost insensitive to X-rays. On the other hand, the higher XEL response of long ZnO NRs, which is a key parameter for evaluation of materials to be used as scintillators for high quality X-ray detection and imaging, along with a decay time response in the order of ns confirmed promising scintillation properties for fast and high-resolution X-ray detector applications.
Linking the composition of cryoconite prokaryotic communities in the Arctic, Antarctic, and Central Caucasus with their chemical characteristics
Authors: Gladkov Grigory V. , Kimeklis Anastasiia K. , Tembotov Rustam Kh. , Ivanov Mikhail N. , Andronov Evgeny E. , Abakumov Evgeny V. 
Published: July 2024

AbstractCryoconites are the deposits on the surface of glaciers that create specific ecological niches for the development of microorganism communities. The sediment material can vary in origin, structure, and nutrient content, creating local variations in the growth conditions. An additional factor of variability is the location of the glaciers, as they are found in different climatic zones in the high mountain regions and closer to the poles. Here, using the analysis of amplicon sequencing of the 16S rRNA gene, we studied the taxonomic composition of the prokaryotic communities from glaciers from remote regions, including the Arctic (Mushketova on the Severnaya Zemlya, IGAN in Polar Ural), Antarctic (Pimpirev on the Livingstone Island) and Central Caucasus (Skhelda and Garabashi) and connected it with the variation of the physicochemical characteristics of the substrate: pH, carbon, nitrogen, macro- and microelements. The cryoconite microbiomes were comprised of specific for this environment phyla (mostly Pseudomonadota, Cyanobacteria, Bacteroidota, Acidobacteriota, and Actinobacteriota), but each glacier had a unique taxonomic imprint. The core microbiome between regions was composed of only a few ASVs, among which the most likely globally distributed ones attributed to Polaromonas sp., Rhodoferax sp., Cryobacterium sp., and Hymenobacter frigidus. The WGSNA defined clusters of co-occurring ASVs between microbiomes, that significantly change their abundance corresponding with the variation of chemical parameters of cryoconites, but do not fully coincide with their regional separation. Thus, our work demonstrates that the chemical characteristics of the sediment material can explain the variation in the cryoconite prokaryotic community which is not always linked to geographic isolation.
Retrospective analysis of neoplasms in patients using angiotensin receptor blockers
Authors: Sharma Arvind Kumar , Rastogi Shruti , Goyal Ramesh K. 
Published: July 2024

AbstractIn recent years, regulatory agencies have raised concerns about the presence of potentially carcinogenic substances in certain formulations of Angiotensin Receptor Blockers (ARBs). Specifically, nitrosamines and azido compounds have been identified in some ARB products. Nitrosamines are known to have carcinogenic properties and are associated with an increased risk of neoplasms. Spontaneous safety reports from the EudraVigilance Data Analysis System (EVDAS) database were analyzed to investigate cases of neoplasms associated with ARBs. A disproportionality analysis was conducted, calculating the reporting odds ratio (ROR) and 95% confidence intervals (CIs) using a case/non-case approach for each ARB drug. The EVDAS database contained 68,522 safety reports related to ARBs (including Azilsartan, Candesartan, Irbesartan, Olmesartan, Losartan, Valsartan, and Telmisartan), among which 3,396 (5%) cases were associated with neoplasms. The majority of these cases were reported in Germany (11.9%), followed by France (9.7%). Approximately 70% of the reports were submitted by healthcare professionals such as physicians and nurses. Among the ARBs, valsartan had the highest ROR for neoplasm (ROR 1.949, 95% CI 1.857–2.046). This association remained significant when comparing ARBs with other classes of antihypertensive drugs, including ACE inhibitors, beta-blockers, calcium channel blockers, and diuretics. Our study identifies a possible signal of an association between ARBs, particularly valsartan, and the risk of neoplasms. However, further observational and analytical studies are necessary to confirm these findings and elucidate the underlying mechanisms.
Development and intrapuparial characterization of Peckia (Euboettcheria) collusor (Curran and Walley, 1934) (Diptera: Sarcophagidae) for application in forensic entomology
Authors: Dias Rayane , Viana Thais , Santos-Mallet Jacenir R. , Alencar Jeronimo , Queiroz Margareth M. C. 
Published: July 2024

AbstractThe family Sarcophagidae is very diverse in Brazil. Due to their living habits, they are the subject of many medical, veterinary, sanitary, and entomological studies. However, Sarcophagidae species are still poorly studied in forensic entomology, although they are frequently reported in carcasses and even human corpses. Thus, this study aims to identify and compare the developmental stages and intrapuparial morphological characteristics of Peckia (Euboettcheria) collusor to serve as an auxiliary tool in forensic entomology. The pupae collected after zero hour at 27 °C and 32 °C were sacrificed every three hours until the first 24 h and then every six hours until the emergence of the first adults, using 30 pupae each time, totaling 1560 for 27 °C and 1290 for 32 °C. The intrapuparial development time of this fly species under laboratory-controlled conditions was 288 h at 27 °C and 228 h at 32 °C. The 2820 pupae were analyzed according to temperature and classified into eight possible stages. This contributed to the selection of 16 key morphological characteristics to identify the age of the pupae. The identified intrapupal morphological characteristics have great potential to help researchers, experts, technical assistants, and forensic entomologists estimate the minimum post-mortem interval (minPMI) of cadavers.
Alternative cryoprotective agent for corneal stroma-derived mesenchymal stromal cells for clinical applications
Authors: Larsen Kristoffer , Petrovski Goran , Boix-Lemonche Gerard 
Published: July 2024

AbstractCryopreservation of human corneal stroma-derived mesenchymal stromal cells (hCS-MSCs) with dimethylsulfoxide (DMSO) as a cryoprotective agent (CPA) has not been previously compared to that with glycerol under standard conditions. The hCS-MSCs were hereby cryopreserved with both compounds using a freezing rate of 1 °C/minute. The CPAs were tested by different concentrations in complete Minimum Essential Medium (MEM) approved for good manufacturing practice, and a medium frequently used in cell laboratory culturing—Dulbecco’s modified eagle serum. The hCS-MSCs were isolated from cadaveric human corneas obtained from the Norwegian Eye Bank, and immunophenotypically characterized by flow cytometry before and after cryopreservation. The survival rate, the cellular adhesion, proliferation and cell surface coverage after cryopreservation of hCS-MSCs has been studied. The hCS-MSCs were immunofluorescent stained and examined for their morphology microscopically. The results showed that cryopreservation of hCS-MSCs in MEM with 10% glycerol gives a higher proliferation rate compared to other cryopreserving media tested. Based on the results, hCS-MSCs can safely be cryopreserved using glycerol instead of the traditional use of DMSO.
Sleep benefits perceptual but not movement-based learning of locomotor sequences
Authors: Borin Gabriela , Sato Sumire D. , Spencer Rebecca M. C. , Choi Julia T. 
Published: July 2024

AbstractPracticing complex locomotor skills, such as those involving a step sequence engages distinct perceptual and motor mechanisms that support the recall of learning under new conditions (i.e., skill transfer). While sleep has been shown to enhance learning of sequences of fine movements (i.e., sleep-dependent consolidation), here we examined whether this benefit extends to learning of a locomotor pattern. Specifically, we tested the perceptual and motor learning of a locomotor sequence following sleep compared to wake. We hypothesized that post-practice sleep would increase locomotor sequence learning in the perceptual, but not in the motor domain. In this study, healthy young adult participants (n = 48; 18–33 years) practiced a step length sequence on a treadmill cued by visual stimuli displayed on a screen during training. Participants were then tested in a perceptual condition (backward walking with the same visual stimuli), or a motor condition (forward walking but with an inverted screen). Skill was assessed immediately, and again after a 12-h delay following overnight sleep or daytime wake (n = 12 for each interval/condition). Off-line learning improved following sleep compared to wake, but only for the perceptual condition. Our results suggest that perceptual and motor sequence learning are processed separately after locomotor training, and further points to a benefit of sleep that is rooted in the perceptual as opposed to the motor aspects of motor learning.