bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volume–outcomes relationship in the Era of modern coronary intervention—results from the prospective multicenter German DES.DE Registry
Authors: Akin Ibrahim , Hochadel Mathias , Schneider Steffen , Abdel‐Wahab Mohamed , Zahn Ralf , Senges Jochen , Richardt Gert , Kuck Karl‐Heinz , Nienaber Christoph A. ,   for the DES.DE Study group
Published: May 2013

ObjectiveWe compare clinical outcomes among unselected patients undergoing percutaneous coronary intervention (PCI) with drug‐eluting stents (DES) stratified in categories of treating hospital PCI volume.BackgroundPrevious observational evidence suggests an inverse relation between hospital volume and patients' outcomes. However, there are no mid‐term outcomes data with the use of DES.MethodsWe used data from DES.DE (German Drug‐Eluting Stent) registry to compare in‐hospital and 1‐year outcomes among unselected patients. Primary endpoints at one year follow‐up were the rate of major adverse cardiac and cerebrovascular events (MACCE) and target vessel revascularization (TVR).ResultsBetween 2005 and 2006, 2,075 patients were treated in group I hospitals (<1,000 PCIs/year), 1,624 in group II hospitals (1,000–1,500 PCIs/year), and 1,790 in group III hospitals (>1,500 PCIs/year). Compared with group II and group III, group I allocation was associated with higher rates of overall hospital mortality (1.1% versus 0.2% versus 0.2%; P < 0.0001) and severe bleeding (1.0% versus 0.4% versus 0.5%; P < 0.05); similarly, poorer outcomes with respect to MACCE (7.2% versus 6.5% versus 4.7%; P < 0.01), stent thrombosis (5.2% versus 5.0% versus 3.0%; P < 0.01), and non‐fatal stroke (1.5% versus 0.9% versus 0.7%; P < 0.05) were documented in group I. Conversely, TVR rates were highest in group II (10.2% versus 14.2% versus 11.7%; P < 0.01); these differences persisted after risk adjustment for heterogeneous baseline characteristics.ConclusionsIn the era of modern coronary intervention technological advances such as DES have not offset the inverse relation between procedural volume and both in‐hospital and 1‐year outcomes after PCI. © 2013 Wiley Periodicals, Inc.
Combined prospective United States clinical study data for the GORE® HELEX® septal occluder device
Authors: Rhodes John F. , Goble Jake 
Published: May 2013

ObjectivesOur goal was to summarize the outcome for all subjects evaluated during a prospective clinical study in the United States with the GORE® HELEX® Septal Occluder for transcatheter repair of secundum atrial septal defects (ASD).BackgroundThe GORE® HELEX® Septal Occluder is currently utilized for repair of secundum ASD. No previous reports are available that summarize the combined clinical trial outcomes for this device.MethodsIn the United States between 1999 and 2009, 435 subjects were enrolled through the Feasibility, Pivotal, Continued Access, and Post‐Approval Studies. All subjects enrolled through these studies were collectively reviewed as the “study cohort.” Clinical success, defined as a composite evaluation of safety and efficacy, is reported for subjects at the 12‐month follow‐up period.ResultsOf the 435 device subjects enrolled in the four clinical studies, 412 subjects were eligible for follow‐up. Device efficacy, as represented by clinical closure at 12 months, was achieved in 98.3% of subjects, and in 99.5% of those receiving a device whose nominal diameter was greater or equal to twice the balloon sized defect diameter. Through 12 months following implantation, freedom from major adverse events was 95.2%. Together, these results yield a 93.0% composite clinical success at 12 months following the index procedure.ConclusionsThe combined clinical study cohort represents the largest prospective, controlled clinical trial data set available for the GORE® HELEX® Septal Occluder. The clinical data presented in this report reaffirm the safety and efficacy of the GORE® HELEX® Septal Occluder when utilized for secundum atrial septal defect repair. © 2013 Wiley Periodicals, Inc.
Efficacy and safety of transulnar coronary angiography and interventions—A single center experience
Authors: Deshmukh Anand R. , Kaushik Manu , Aboeata Ahmed , Abuzetun Jamil , Burns Tammy L. , Nubel Caroline A. , White Michael D. , Lanspa Thomas J. , Hunter Claire B. , Mooss Aryan N. , Esterbrooks Dennis J. 
Published: May 2013

ObjectivesTo evaluate the efficacy and long‐term safety of transulnar approach in complex coronary interventions.BackgroundThe success rate of transulnar approach in complex coronary interventions and its long‐term safety remains to be proven.MethodsWe conducted a retrospective chart review of patients undergoing transulnar coronary angiography and interventions at our institution from January 2004 through July 2009. Primary endpoint of the study was the success rate of the procedure. Secondary endpoints were major bleeding, local vascular and neurological complications, cerebrovascular accident (CVA)/transient ischemic attack (TIA), myocardial infarction (MI), all‐cause mortality, and major adverse cardiovascular events (MACE) rate that was a composite of MI, CVA/TIA, and all‐cause mortality.ResultsOf 81 patients undergoing transulnar approach, 41 (50.6%) patients underwent intervention on 65 lesions. Twelve percent of the interventions were performed on coronary bypass grafts and 9.2% on the left main coronary artery. Success rates for transulnar access, coronary angiography, and coronary/bypass graft interventions were 93.8%, 100%, and 92.6%, respectively. Follow‐up data was available on 71 patients at short term (30 days) and 58 patients at long term (1 year). At 30‐day follow‐up, vascular complication rate was 2.8 %. At 1‐year follow‐up, there were no residual deficits from vascular or neurological complications associated with the index procedure and the overall MACE rate was 3.4%.ConclusionIn this first study evaluating long‐term safety and feasibility of transulnar coronary angiography and complex coronary interventions, we conclude that transulnar approach appears to be safe and effective. © 2013 Wiley Periodicals, Inc.
Coordination‐Based Molecular Assemblies of Oligofurans and Oligothiophenes
Authors: Hayoun Barak Adva , de Ruiter Graham , Lahav Michal , Sharma Sagar , Gidron Ori , Evmenenko Guennadi , Dutta Pulak , Bendikov Michael , van der Boom Milko E. 
Published: May 2013

AbstractMolecular assemblies (MAs) of oligofurans and oligothiophenes were formed from solutions on various substrates. These films were obtained by alternating deposition of organic chromophores (oligofurans or oligothiophenes) and a palladium salt. These coordination‐based MAs were characterized by UV/Vis spectroscopy, spectroscopic ellipsometry, atomic force microscopy (AFM), X‐ray reflectivity (XRR), X‐ray photoelectron spectroscopy (XPS), and electrochemistry. The MAs exhibit similar electrochemical behavior and their growth and structure are apparently not affected when different organic template layers are used. The density of the MAs is a function of the structure of the molecular component. The oligothiophene density is approximately 50 % higher than that observed for the oligofuran‐based assemblies. The optical and electrochemical properties of the MAs scale linearly with their thickness. The UV/Vis data indicate that upon increasing the film thickness, there is no significant conjugation between the metal‐separated organic chromophores. DFT calculations confirmed that the HOMO–LUMO gap of the surface‐bound oligofuran and oligothiophene metal oligomers do not change significantly upon increasing their chain length. However, electrochemical measurements indicate that the susceptibility of the MAs towards oxidation is dependent on the number of chromophore units.
Stepwise Encapsulation of Sulfate Ions by Ferrocenyl‐Functionalized Tripodal Hexaurea Receptors
Authors: Huang Xiaojuan , Wu Biao , Jia Chuandong , Hay Benjamin P. , Li Minrui , Yang Xiao‐Juan 
Published: May 2013

AbstractThree ferrocenyl‐functionalized tripodal hexaurea anion receptors with ortho‐ (L2), meta‐ (L3), and para‐phenylene (L4) bridges, which showed strong binding affinities toward sulfate ions, have been designed and synthesized. In particular, meta‐phenylene‐bridged ligand L3, owing to its trigonal bipyramidal structure, can encapsulate two SO42− ions in its “inner” and “outer” tripodal clefts, respectively, as supported by their clearly distinct NMR resonances and by molecular modeling. The sulfate complex of ortho‐ligand L2, (TBA)2[SO4⊂L2]⋅2 H2O (1), displays a caged tetrahedral structure with an encapsulated sulfate ion that is hydrogen bonded by the six urea groups of ligand L2. CV studies showed two types of electrochemical response of the ferrocene/ferrocenium redox couple upon anion binding, that is, a shift of the wave and the appearance of a new peak. Quantitative binding data were obtained from the NMR and CV titrations.
Chelation‐Assisted Cross‐Coupling of Anilines through In Situ Activation as Diazonium Salts with Boronic Acids under Ligand‐, Base‐, and Salt‐Free Conditions
Authors: Joncour Roxan , Susperregui Nicolas , Pinaud Noël , Miqueu Karinne , Fouquet Eric , Sotiropoulos Jean‐Marc , Felpin François‐Xavier 
Published: May 2013

AbstractWe describe the coupling of anilines with aryl boronic acids, under ligand‐, base‐, and salt‐free conditions at room temperature. This new reaction proceeds through the formation of an aryl palladium alkoxo complex, which allows the transmetalation step with aryl boronic acids without any external base. Importantly, this sustainable procedure generates only environmentally friendly byproducts such as tBuOH, H2O, N2, and B(OH)3. The reaction mechanism has been deeply investigated through experimental and theoretical studies.
Impact of Tesamorelin, a Growth Hormone‐Releasing Factor (GRF) Analogue, on the Pharmacokinetics of Simvastatin and Ritonavir in Healthy Volunteers
Authors: Teng Shirley , Potvin Diane , Mamputu Jean‐Claude , Vincent Geneviève , Zoltowska Monika , Morin Josée , Hatimi Saida , Michaud Sophie‐Elise , High Kim , Ducharme Murray P. 
Published: May 2013

AbstractThe potential impact of tesamorelin on CYP3A activity was investigated by examining its effect on the pharmacokinetics of simvastatin and ritonavir. In two randomized, two‐way crossover studies, subjects were administered 2 mg tesamorelin on Days 1–7 with 80 mg simvastatin or 100 mg ritonavir co‐administered on Day 6 (Treatment A), and a single dose of simvastatin or ritonavir alone on Day 6 (Treatment B). Pharmacokinetic samples were collected on Day 6 to measure simvastatin, ritonavir and tesamorelin plasma concentrations. For simvastatin, A/B ratios of least squares geometric means and corresponding 90% confidence intervals (CIs) for AUC0−t, AUC0−inf and Cmax were contained within the usual no effect range of 80–125%. For ritonavir, ratios and 90% CIs for AUCs were within this acceptance range, but the lower CI for Cmax was 74.8%, suggesting a decreased rate of exposure. However, since the A/B ratios for AUCs and Cmax parameters were approximately 90%, these were minor decreases and no dose adjustment of ritonavir is required in the presence of tesamorelin. These studies showed that the impact of tesamorelin on CYP3A activity appears to be minimal, if any. Either medication may be co‐administered with tesamorelin in patients without changing their original dosing regimen.
What makes an optimization problem hand?
Authors: Macready William G. , Wolpert David H. 
Published: May 2013

AbstractWe address the question: “Are some classes of combinatorial optimization problems intrinsically harder than others, without regard to the algorithm one uses, or can difficulty only be assessed relative to particular algorithms?” We provide a measure of the hardness of a particular optimization problem for a particular optimization algorithm and present two algorithm‐independent quantities that use this measure to provide answers to our question. In the first of these we average hardness over all possible algorithms and show that according to this quantity, there are no distinctions between optimization problems. In this sense no problems are intrinsically harder than others. For the second quantity, rather than average over all algorithms, we consider the level of hardness of a problem (or class of problems) for the associated optimal algorithm. By this criteria there are classes of problems that are intrinsically harder than others.
A Micro‐pulse Process of Atomic Layer Deposition of Iron Oxide Using Ferrocene and Ozone Precursors and Ti‐Doping
Authors: Li Xianglin , Fan Ng Chin , Fan Hong Jin 
Published: May 2013

AbstractHematite (α‐Fe2O3) thin films are obtained by atomic layer deposition (ALD) in the temperature range 200 − 350°C using ferrocene and ozone as the precursors. A micro‐pulse process facilitates the precursor adsorption and shortens the ferrocene dose time to 5 s. When tested on Si(100) substrates, the growth rate is around 0.5 Å per cycle for the first 300 cycles, after which the growth becomes nonlinear. Interestingly, a linear growth can be maintained with a rate of ≈0.55 Å per cycle by TiO2 co‐deposition (cycle ratio of TiO2/Fe2O3 = 1:20). Characterizations by X‐ray photoemission spectroscopy (XPS), Raman spectroscopy (RS), and UV‐vis absorption confirm the presence of the α‐Fe2O3 phase after post‐deposition annealing. Uniform depositions on dense ZnO nanorod arrays and anodic aluminum oxide (AAO) templates are also demonstrated, inferring that the current process is capable of coating on high (>50) aspect ratio structures.
Detecting intentional insulin omission for weight loss in girls with type 1 diabetes mellitus
Authors: Pinhas‐Hamiel Orit , Hamiel Uri , Greenfield Yuval , Boyko Valentina , Graph‐Barel Chana , Rachmiel Marianna , Lerner‐Geva Liat , Reichman Brian 
Published: May 2013

ABSTRACTObjectiveIntentional insulin omission is a unique inappropriate compensatory behavior that occurs in patients with type 1 diabetes mellitus, mostly in females, who omit or restrict their required insulin doses in order to lose weight. Diagnosis of this underlying disorder is difficult. We aimed to use clinical and laboratory criteria to create an algorithm to assist in the detection of intentional insulin omission.MethodThe distribution of HbA1c levels from 287 (181 females) patients with type 1 diabetes were used as reference. Data from 26 patients with type 1 diabetes and intentional insulin omission were analysed. The Weka (Waikato Environment for Knowledge Analysis) machine learning software, decision tree classifier with 10‐fold cross validation was used to developed prediction models. Model performance was assessed by cross‐validation in a further 43 patients.ResultsAdolescents with intentional insulin omission were discriminated by: female sex, HbA1c>9.2%, more than 20% of HbA1c measurements above the 90th percentile, the mean of 3 highest delta HbA1c z‐scores>1.28, current age and age at diagnosis. The models developed showed good discrimination (sensitivity and specificity 0.88 and 0.74, respectively). The external test dataset revealed good performance of the model with a sensitivity and specificity of 1.00 and 0.97, respectively.DiscussionUsing data mining methods we developed a clinical prediction model to determine an individual's probability of intentionally omitting insulin. This model provides a decision support system for the detection of intentional insulin omission for weight loss in adolescent females with type 1 diabetes mellitus. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:819–825)
Sedimentation and flow patterns induced by regular and modified groynes on the River Elbe, Germany
Authors: Henning Martin , Hentschel Bernd 
Published: May 2013

ABSTRACTGroynes help to protect river banks and support water levels for navigation. Since recently, groyne fields are considered as surrogate habitat for various species and may, in terms of ecology, partially replace flood plains that were lost in the course of river training in the last centuries. In order to maintain and improve the hydraulic function and ecological value of groyne fields, the German Federal Institutes of Hydrology and the Waterways Engineering and Research studied innovative groyne types and regular groynes on the River Elbe, Germany. In a 10‐year field campaign, groyne field hydraulics and morphology were monitored using acoustic Doppler current profiler and echo‐sounding techniques. The data is used to assess groyne field heterogeneity and morphodynamics over the 10‐year period as well as flow patterns at different flow stages. The results indicate a high morphological activity in the groyne fields associated with flood discharges. Significant sedimentation in the bank regions was observed, whereas sedimentation in deeper areas of the groyne fields was less pronounced. The sedimentation patterns and rates in the groyne fields are, to some extent, found to be influenced by different groyne types and associated flow patterns. Copyright © 2013 John Wiley & Sons, Ltd.
Characterization of the fluxes and stores of water within newly formed Sphagnum moss cushions and their environment
Authors: Ketcheson Scott J. , Price Jonathan S. 
Published: May 2013

ABSTRACTInternal water storage and water exchanges that sustain hydration are critical for the physiological function of Sphagnum mosses that have recolonized cutover peatlands characterized by low soil–water pressures. The relative importance of water gains and losses for spontaneously regenerated Sphagnum moss cushions was addressed through investigation of the sensitivity of moss moisture dynamics to a range of environmental variables. Precipitation waters are poorly retained within the cushions, which indicated that rain event water can only be relied upon by the mosses for a short period. The relationship between water table depth and moisture content within moss cushions was strong when the water table was within 30 cm of the surface of the cutover peat but weakened as conditions became drier, as reflected by weakened upward hydraulic gradients in the unsaturated zone below the moss cushions. Calculation of a water budget between 19 May and 16 August 2006 for relatively wet and dry cushions, respectively, identified a water deficit of 28 and 44 mm. It is hypothesized that additional (small) sources of water during deficit conditions may be critical for maintaining physiological processes. Rewetting of the peatland by blocking drainage ditches created conditions more favourable for Sphagnum survival through increasing the moisture content and soil–water pressures within the remnant peat deposit although restoration efforts should aim to constrain the water table position to within the upper 30 cm. Copyright © 2013 John Wiley & Sons, Ltd.
From random variability to ordered structures: a search for general synthesis in ecohydrology
Authors: Porporato Amilcare , Rodriguez‐Iturbe Ignacio 
Published: May 2013

ABSTRACTWe present our personal view of some of the exciting research avenues in ecohydrology, which are related to quantifying the effects of hydrologic variability and anthropogenic disturbance on ecohydrological processes. Using several examples, we discuss how concepts and tools inspired from information theory, statistical mechanics and nonequilibrium thermodynamics may help us advance in some of the challenges posed by the need to sustainably manage our soil and water resources, while preserving ecosystem services. Copyright © 2013 John Wiley & Sons, Ltd.
Theoretical Study on Cationic Iridium(III) Complexes with a Diphosphane Ligand – Geometry, Electronic Properties, and Application for Light‐Emitting Electrochemical Cells
Authors: Qu Xiaochun , Liu Yuqi , Godefroid Gahungu , Si Yanling , Shang Xiaohong , Wu Xue , Wu Zhijian 
Published: May 2013

AbstractA DFT/time‐dependent DFT (TD‐DFT) investigation was conducted on a series of cationic iridium(III) complexes with 2‐phenylpyridine (ppyn) derivatives and a diphosphane (PPn) ancillary ligand to shed light on the effects of stereoisomerism and ligand substituents on the photophysical properties. The geometries, electronic structures, lowest‐lying singlet–singlet absorptions, vertical singlet–triplet excitations, and triplet–singlet emissions of N,N‐cis‐[Ir(ppy0)2(PP)]+ (1), N,N‐trans‐[Ir(ppy0)2(PP)]+ (2) and their derivatives were investigated with DFT‐based approaches [ppy0 = 2‐phenylpyridine, PP = 1,2‐bis(diphenylphosphanyl)ethene]. The complex N,N‐trans‐[Ir(ppy2)2(PP2)]+ (3b) shows high quantum phosphorescence efficiency (ΦPL) of 91 %, whereas an extremely low ΦPL (<1 %) was observed for N,N‐trans‐[Ir(ppy4)2(PP1)]+ (2d). To clarify this behavior, the S1–Tn splitting energy (ΔE), the transition dipole moment (μ) upon the S0→S1 transition, and the energy gap between the triplet metal‐to‐ligand charge transfer (3MLCT) π–π* and triplet metal‐centered (3MC) d–d states (ΔEMC–MLCT) were calculated. A drastically small ΔE and large μ for 3b (<0.05 eV and 1.38 D, respectively), compared to those for 2d (>0.2 eV and 1.26 D, respectively), were found to be closely linked to the substituents on the ppyn ligands. The remarkably small ΔE and similar μ for N,N‐cis 1c (<0.05 eV and 1.41 D, respectively), compared to those for N,N‐trans 2c (>0.1 eV and 1.42 D, respectively), could be attributed to the effects of the trans–cis structural isomerism. On the basis of these parameters, the higher ΦPL of 3b with respect to that of 2d was explained, and 1c, 1d, 2b, and 2e were considered to have better physical properties than the experimentally synthesized complexes 2, 2d, and 3b. The newly designed 1c, 1d, 2b, and 2e are expected to be highly emissive in the blue‐green region for light‐emitting electrochemical cell (LEC) applications.
Sequential [3+2] Cycloaddition/Air Oxidation Reactions: Triazoloyl Ion Assisted Oxidative Cleavage of Alkynes
Authors: Ponpandian Thanasekaran , Muthusubramanian Shanmugam , Rajagopal Sridharan 
Published: May 2013

AbstractUpon treatment with sodium azide in DMF, bisalkynes undergo chemoselective [3+2] cycloaddition followed by oxidative cleavage of the other alkyne unit by atmospheric oxygen. The neighboring triazoloyl ion is found to assist the cleavage process ultimately to deliver an acid and an aldehyde.
Catalytic Enantioconvergent Decarb­oxylative Allylic Alkylation of Allyl Indol­enin‐3‐carboxylates
Authors: Kaiser Thomas M. , Yang Jiong 
Published: May 2013

AbstractA catalytic enantioconvergent process has been developed for the conversion of racemic allyl indolenin‐3‐carboxylates into enantiomerically enriched C3‐quaternary indolenines. A Pd‐catalyzed decarboxylative allylic alkylation reaction was employed for both stereoablation of the racemic allyl indolenin‐3‐carboxylates and enantioselective formation of the quaternary carbon center.
Detection of Trace Zinc by an Electrochemical Microsensor based on Carbon Nanotube Threads
Authors: Guo Xuefei , Lee Woo Hyoung , Alvarez Noe , Shanov Vesselin N. , Heineman William R. 
Published: May 2013

AbstractCarbon nanotubes (CNTs) have attracted intense interest due to their excellent properties, such as increased electrode surface area, fast electron transfer rate, significant mechanical strength and good chemical stability. CNT threads, spun from shorter CNTs, inherit the advantages of CNTs, while avoiding the potential toxicity caused by individual CNTs. In this work, microelectrodes based on CNT threads were used to detect trace zinc by anodic stripping voltammetry with an estimated detection limit of 1.4 nM without mercury or bismuth films. CNT threads showed promise for measuring trace metals in small sample volumes without stirring such as encountered in some in vivo and in vitro applications.