bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histopathological features of clinical perineural invasion of cutaneous squamous cell carcinoma of the head and neck and the potential implications for treatment
Authors: Panizza Benedict , Warren Timothy A. , Solares C. Arturo , Boyle Glen M. , Lambie Duncan , Brown Ian 
Published: October 2013

AbstractBackgroundNonmelanoma skin cancer (NMSC) with perineural invasion (PNI) is most commonly seen in cutaneous squamous cell carcinoma of the head and neck (SCCHN). The cranial nerves are a conduit for skin cancer to reach the brainstem.MethodsThe histopathological features of 51 tissue specimens from 49 patients with cutaneous SCCHN and clinical PNI were assessed with consecutive transverse and longitudinal sections.ResultsNo skip lesions were identified. Tumor spread was contiguous in all specimens. No tumor spread into the perineural space from surrounding or adjacent tumor was seen. Proximal large cranial nerves showed epineural involvement in 3.9% in areas with large tumor bulk, extensive PNI, and intraneural invasion.ConclusionPerineural tumor spread in cutaneous SCCHN was contiguous and no skip lesions were evident in nerve specimens assessed in this series. Spread beyond cranial nerve perineurium was uncommon, reflecting its multilayer barrier function at this level. These findings may have treatment implications. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1611–1618, 2014
Comparison of complications in free flap reconstruction for osteoradionecrosis in patients with or without hyperbaric oxygen therapy
Authors: Nolen David , Cannady Steven B. , Wax Mark K. , Scharpf Joseph , Puscas Liana , Esclamado Ramon M. , Fritz Michael , Freiberger John , Lee Walter T 
Published: October 2013

ABSTRACTBackgroundHyperbaric oxygen (HBO) therapy induces native tissue oxygenation. The hypothesis was patients with mandibular osteoradionecrosis (ORN) and a history of HBO therapy would have less free flap reconstruction complications than patients without HBO therapy.MethodsWe conducted a multisite retrospective review involving radical debridement and free flap reconstruction for ORN between January 1, 1995 and June 30, 2011. Patients were stratified based on receiving prior HBO therapy or not.ResultsThirty‐nine of 89 patients (43.8%) had HBO therapy whereas 50 of 89 (56.2%) did not. The HBO therapy group had significantly less patients with diabetes. There was no statistical difference in overall complication in patients between groups (p = .5478). However, there was marginal significance of increased infections in the patients with a history of HBO therapy (p = .0545).ConclusionAlthough no significant differences in free flap reconstruction complication rates were observed between these 2 patient cohorts, there was marginal significance of increased infections in the patients with a history of HBO therapy. A prospective multi‐institutional randomized study examining issues of infection would address issues inherent in this retrospective study. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1701–1704, 2014
Validation of Western common recurrent chromosomal aberrations in Korean chronic lymphocytic leukaemia patients with very low incidence
Authors: Yoon Jae‐Ho , Kim Yoonjoo , Yahng Seung‐Ah , Shin Seung‐Hwan , Lee Sung‐Eun , Cho Byung‐Sik , Eom Ki‐Seong , Kim Yoo‐Jin , Lee Seok , Kim Hee‐Je , Min Chang‐Ki , Kim Dong‐Wook , Lee Jong‐Wook , Min Woo‐Sung , Park Chong‐Won , Lim Jihyang , Kim Yonggoo , Han Kyungja , Kim Myungshin , Cho Seok‐Goo 
Published: October 2013

AbstractIn Asia, the incidence of chronic lymphocytic leukaemia (CLL) is lower than in Western countries. Only a few studies of CLL have been conducted in Korea, and no long‐term clinical outcome data are available. We assessed the frequency of common chromosomal aberrations in Korean CLL patients using interphase fluorescence in situ hybridization (FISH) and investigated their relationship to clinical outcomes. Between 2000 and 2011, conventional cytogenetic studies were performed in 58 patients, and FISH results were available in 48 patients. We used six DNA probes for the detection of del(13q14), trisomy 12, del(11q22), del(17p13), IGH rearrangement and del(6q23). Chromosomal aberrations were identified in 15 of 58 patients (26%) with conventional cytogenetic studies and in 25 of 48 patients (52%) with interphase FISH, including six patients with complex karyotypes. In contrast with the results of Western studies, trisomy 12 was the most common aberration, followed by IGH rearrangement, del(13q14), del(11q22) and del(17p13). Deletion of 6q23 was not observed, and isolated del(13q14) was less frequent than in Western studies. Compared with the other types of chromosomal aberrations, patients with del(11q22) and del(17p13) were more likely to be Rai stage 3–4 and Binet stage C, resulting in poor responses to chemotherapy and worse outcomes. In contrast, patient with trisomy 12 and isolated del(13q14) showed better responses and superior survival outcomes. The incidence of CLL is lower in Korea than in Western countries, and the frequency of chromosomal aberrations differs, perhaps reflecting differences in the pathogenic mechanism between ethnicities. Large prospective studies are needed to further assess the prognostic value of these results in Korean CLL patients. Copyright © 2013 John Wiley & Sons, Ltd.
Secondary nonmotor negative symptoms in healthy volunteers after single doses of haloperidol and risperidone: a double‐blind, crossover, placebo‐controlled trial
Authors: Mas Sergi , Gassó Patricia , Fernández de Bobadilla Ramón , Arnaiz Joan Albert , Bernardo Miquel , Lafuente Amalia 
Published: October 2013

ObjectiveThe effect of antipsychotics (APs) on negative symptoms is controversial. The present study assessed negative symptoms in healthy volunteers without any source of primary negative symptoms after single doses of haloperidol and risperidone.MethodsTwenty‐five healthy subjects were included in this randomized, placebo‐controlled, single‐dose (haloperidol 5 mg and risperidone 2.5 mg) crossover and double‐blind clinical trial. Negative symptoms were assessed by observer‐rated scales and with a self‐report scale. Possible confounding effects considered were extrapyramidal symptoms (EPS) and sedative effects. The occupation of striatal dopamine D2 receptors was also determined.ResultsRisperidone induced a wide range of negative symptoms such as alogia, blunted affect, avolition/apathy, and attention impairment, whereas haloperidol only induced the avolition/apathy subdomain. Most of the effects of risperidone in healthy volunteers, with the exception of its effects on avolition/apathy, were attributable to AP‐induced EPS. Haloperidol did not cause significant EPS after administration. No effect of sedation or psychomotor performance was observed on negative symptoms.ConclusionsSingle doses of both haloperidol and risperidone induced nonmotor secondary negative symptoms in healthy volunteers. The clinical findings are especially relevant in view of the impact of negative symptoms on poor functioning. They may help to guide clinicians in their choice of APs (http://clinicaltrials.gov/ct2/show/NCT01259973). Copyright © 2013 John Wiley & Sons, Ltd.
Abnormal maximal finger tapping in abstinent cannabis users
Authors: Flavel Stanley C. , White Jason M. , Todd Gabrielle 
Published: October 2013

ObjectiveTo investigate movement speed and rhythmicity in abstinent cannabis users, we hypothesized that abstinent cannabis users exhibit decreased maximal finger tapping frequency and increased variability of tapping compared with non‐drug users.MethodsThe study involved 10 healthy adult cannabis users and 10 age‐matched and gender‐matched controls with no history of illicit drug use. Subjects underwent a series of screening tests prior to participation. Subjects were then asked to tap a strain gauge as fast as possible with the index finger of their dominant hand (duration 5 s).ResultsThe average intertap interval did not significantly differ between groups, but the coefficient of variation of the intertap interval was significantly greater in the cannabis group than in controls (p = 0.011). The cannabis group also exhibited a slow tapping frequency at the beginning of the task.ConclusionsRhythmicity of finger tapping is abnormal in individuals with a history of cannabis use. The abnormality appears to be long lasting and adds to the list of functional changes present in abstinent cannabis users. Copyright © 2013 John Wiley & Sons, Ltd.
Eddy covariance‐based evapotranspiration for a subtropical wetland
Authors: Wu Chin‐Lung , Shukla Sanjay 
Published: October 2013

AbstractThe eddy covariance (EC) method was used in a 30‐month study to quantify evapotranspiration (ET) and vegetation coefficient (KCW) for a wetland on a ranch in subtropical south Florida. To evaluate the errors in ET estimates, the EC‐based ET (ETC‐EC) and the Food and Agricultural Organization (FAO) Penman–Monteith (PM) based ET (ETC‐PM) estimates (with literature crop coefficient, KC) were compared with each other. The ETC‐EC and FAO‐PM reference ET were used to develop KCW. Regression models were developed to estimate KCW using climatic and hydrologic variables. Annual and daily ETC‐EC values were 1152 and 3.27 mm, respectively. The FAO‐PM model underestimated ET by 25% with ETC‐EC being statistically higher than ETC‐PM. The KCW varied from 0.79 (December) to 1.06 (November). The mean KCW for the dry (November–April) season (0.95) was much higher than values reported for wetlands in literature; whereas for the wet (May–October) season, KCW (0.97) was closer to literature values. Higher than expected KCW values during the dry season were due to higher temperature, lower humidity and perennial wetland vegetation. Regression analyses showed that factors affecting the KCW were different during the dry (soil moisture, temperature and relative humidity) and wet (net radiation, inundation and wind speed) seasons. Separate regression models for the dry and wet seasons were developed. Evapotranspiration and KCW from this study, one of the first for the agricultural wetlands in subtropical environment, will help improve the ET estimates for similar wetlands. Copyright © 2013 John Wiley & Sons, Ltd.
Should the Three Gorges Dam be blamed for the extremely low water levels in the middle–lower Yangtze River?
Authors: Lai Xijun , Jiang Jiahu , Yang Guishan , Lu X. X. 
Published: October 2013

AbstractExtremely low water level events have frequently occurred in the middle–lower Yangtze River (MLYR) in recent years (2006–2011). Most of these drought events coincided with the initial operation of the Three Gorges Dam (TGD). The TGD was therefore the focus of controversy about the causes of the hydrological droughts of the rivers and lakes of the region. We quantified the effects of the TGD's operation on water levels from 2006 to 2011 using a newly developed hydrodynamic model. The operation of the TGD significantly exacerbated the severe hydrological droughts that occurred in late September to November because of water impoundment, but it increased water levels from April to early June in the MLYR because of the drawdown of TGD water levels. Evidence suggests that the recent extremely low water levels were mainly because of the remarkable decline in inflows to the MLYR resulting from precipitation changes and possible human activities. Nevertheless, it should be noted that the effects of the TGD on downstream rivers and lakes will be intensified in the foreseeable future. Copyright © 2013 John Wiley & Sons, Ltd.
Short‐term flood inundation prediction using hydrologic‐hydraulic models forced with downscaled rainfall from global NWP
Authors: Nam Do Hoai , Mai Dang Thanh , Udo Keiko , Mano Akira 
Published: October 2013

AbstractA short‐term flood inundation prediction model has been formulated based on the combination of the super‐tank model, forced with downscaled rainfall from a global numerical weather prediction model, and a one‐dimensional (1D) hydraulic model. Different statistical methods for downscaled rainfall have been explored, taking into account the availability of historical data. It has been found that the full implementation of a statistical downscaling model considering physically‐based corrections to the numerical weather prediction model output for rainfall prediction performs better compared with an altitudinal correction method. The integration of the super‐tank model into the 1D hydraulic model demonstrates a minimal requirement for the calibration of rainfall–runoff and flood propagation models. Updating the model with antecedent rainfall and regular forecast renewal has enhanced the model's capabilities as a result of the data assimilation processes of the runoff and numerical weather prediction models. The results show that the predicted water levels demonstrate acceptable agreement with those measured by stream gauges and comparable to those reproduced using the actual rainfall. Moreover, the predicted flood inundation depth and extent exhibit reasonably similar tendencies to those observed in the field. However, large uncertainties are observed in the prediction results in lower, flat portions of the river basin where the hydraulic conditions are not properly analysed by the 1D flood propagation model. Copyright © 2013 John Wiley & Sons, Ltd.
Human pre‐B cell receptor signal transduction: evidence for distinct roles of PI3kinase and MAP‐kinase signalling pathways
Authors: Anbazhagan Kolandaswamy , Rabbind Singh Amrathlal , Isabelle Piec , Stella Ibata , Céline Alleaume‐De Martel , Bissac Eliane , Bertrand Brassart , Rémy Nyga , Naomi Taylor , Vincent Fuentes , Rochette Jacques , Lassoued Kaïss 
Published: October 2013

AbstractPre‐BCR acts as a critical checkpoint in B cell development. However, its signalling cascade still remains indistinctly characterised in human. We investigated pre‐BCR signalling pathway to examine its regulation in normal primary pre‐B lymphocytes and pre‐B cell lines. In cell lines, early signalling events occurring after pre‐BCR stimulation include phosphorylation of Lyn, Blk and Syk together with ZAP70, Btk, Vav, PLC‐γ2 and various adaptor proteins, such as BLNK, LAB, LAT and SLP‐76. Further downstream, these molecules induced activation of the PI3K/AKT and MAP‐kinase resulting in an augmentation of canonical NF‐κB pathways and cFos/AP1 activation. PI3K and MAPK exerted opposing effects on the pre‐BCR‐induced activation of the canonical NF‐κB and c‐Fos/AP1 pathways. Immediate nuclear export of FoxO3A and delayed import of IRF4 were additional events observed after pre‐BCR crosslinking in primary cells. Pre‐BCR‐induced down‐regulation of Rag1, Rag2, E2A and Pax5 transcripts occurred in a PI3K‐dependent manner. Finally we bring evidence that pre‐BCR stimulation or co stimulation with CD19 enhances cell cycle signal.
A DESCRIPTION OF THE MODIFIED ALARM DISTRESS BABY SCALE (m‐ADBB): AN INSTRUMENT TO ASSESS FOR INFANT SOCIAL WITHDRAWAL
Authors: Matthey Stephen , Črnčec Rudi , Hales Alison , Guedeney Antoine 
Published: October 2013

ABSTRACTThis article introduces the m‐ADBB, a modified version of the Alarm Distress Baby Scale (ADBB; A. Guedeney & J. Fermanian, ) used to screen for infant social withdrawal. Social withdrawal can be an indicator of several factors, including infant depression. A brief description is given of various studies that have shown that infants’ behavior, as rated on the ADBB, is associated with poor maternal and paternal mental health as well as with later cognitive development. The original ADBB comprised eight items that clinicians rated on a 5‐point scale. Following work in Australia, this scale was modified to a five‐item checklist, with each item being rated on a 3‐category scale to improve interrater reliability. The m‐ADBB is described, together with data relating to psychometric properties, available training programs, and current studies.
SOCIAL WITHDRAWAL BEHAVIOR IN INSTITUTIONALIZED TODDLERS: INDIVIDUAL, EARLY FAMILY AND INSTITUTIONAL DETERMINANTS
Authors: Baptista Joana , Belsky Jay , Martins Carla , Silva Joana , Marques Sofia , Mesquita Ana , Soares Isabel 
Published: October 2013

ABSTRACTEighty‐five Portuguese children, aged 12 to 30 months, placed in residential institutions were assessed to investigate the influence of variations in the institutionalization experience of social withdrawal behavior, after taking into account potentially confounding individual characteristics and pre‐admission experiences. In light of the limited attention in institutionalization research on social withdrawal, the determinants of the identified predictors of withdrawal symptoms also were examined. Current quality of care experienced in the institution, operationalized in terms of the absence (vs. presence) of a preferred attachment relationship, predicted social withdrawal, such that absence of such a relationship forecasted greater withdrawal. Moreover, existence of a preferred attachment relationship was itself predicted by better child socioemotional functioning, greater caregiver sensitive‐responsiveness, and better quality of individualized care provided by the staff.
ASSOCIATIONS BETWEEN MATERNAL INTERACTION BEHAVIOR, MATERNAL PERCEPTION OF INFANT TEMPERAMENT, AND INFANT SOCIAL WITHDRAWAL
Authors: Puura Kaija , Mäntymaa Mirjami , Leppänen Jukka , Peltola Mikko , Salmelin Raili , Luoma Ilona , Latva Reija , Tamminen Tuula 
Published: October 2013

ABSTRACTInfant social behavior develops in the context of early parent–infant interaction. Persisting withdrawal from social interaction is a sign of infant distress and is linked with the existence of risk factors. Impaired social behavior of the infant not only may be an indicator of pathology in the infant but the first sign of an effect of a psychosocial risk. In this study, we assessed 39 seven‐month‐old infants in videotaped interaction with their mothers and then compared the total score of the infant social behavior rated with the Alarm Distress Baby Scale (ADBB; A. Guedeney & A. Fermanian, ) with variables of mother–infant interaction rated with the Emotional Availability Scales, second edition (EAS 2; Z. Biringen, J. Robinson, & R.N. Emde, ). The ADBB total score had a strong negative correlation with maternal sensitivity in the EAS 2 (r = −0.75) and with the EAS 2 child variables of child involvement (r = 0.82) and child responsiveness (r = 0.85), indicating that the infants with more signs of social withdrawal had less sensitive mothers and were less involving and responsive in the interaction. Against our expectations, the ADBB total score had no correlation with maternal structuring. Our results give further support of the ability of the ADBB to screen for early signs of pathology in infant social behavior and problems in parent–infant interaction.
Forecasting interest rates with shifting endpoints
Authors: van Dijk Dick , Koopman Siem Jan , van der Wel Michel , Wright Jonathan H. 
Published: October 2013

SUMMARYWe consider forecasting the term structure of interest rates with the assumption that factors driving the yield curve are stationary around a slowly time‐varying mean or ‘shifting endpoint’. The shifting endpoints are captured using either (i) time series methods (exponential smoothing) or (ii) long‐range survey forecasts of either interest rates or inflation and output growth, or (iii) exponentially smoothed realizations of these macro variables. Allowing for shifting endpoints in yield curve factors provides substantial and significant gains in out‐of‐sample predictive accuracy, relative to stationary and random walk benchmarks. Forecast improvements are largest for long‐maturity interest rates and for long‐horizon forecasts. Copyright © 2013 John Wiley & Sons, Ltd.
Long‐term maintenance of HepaRG cells in serum‐free conditions and application in a repeated dose study
Authors: Klein Sebastian , Mueller Daniel , Schevchenko Valery , Noor Fozia 
Published: October 2013

ABSTRACTChronic repeated‐dose toxicity studies are still carried out on animals and often do not correlate with the effects in human beings mainly due to species‐specific differences in biotransformation. The human hepatoma cell line HepaRG has been used for human relevant toxicity assessment. However, HepaRG cells are commonly maintained in serum containing medium which limits their use in ’omics‘‐based toxicology. In this study, we compared the maintenance of HepaRG cells in standard serum‐supplemented and serum‐free conditions. Viability and Cytochrome P450 (CYP) activity during long‐term cultivation were assessed. Liver‐specific albumin and urea production was measured. The extracellular metabolome (amino acids, glucose, lactate and pyruvate) was measured to compare different cultivation conditions using metabolic flux analysis. Although metabolic flux analysis reveals differences in certain parts of the metabolism, e.g. production of urea, the overall metabolism of serum‐free and serum‐supplemented cultured HepaRG cells is similar. We conclude that HepaRG cells can be maintained in optimized serum‐free conditions for 30 days without viability change and with high CYP activity. We also tested the acute (24 h) and long‐term repeated‐dose (7 doses, every second day) toxicity of valproic acid. We calculated an EC50 value of 1.4 mM after repeated exposure which is close to the cmax value for valproic acid. Maintenance of HepaRG cells in serum‐free conditions opens up the opportunity for the use of these cells in human long‐term repeated‐dose hepatotoxicity studies and for application in systems toxicology. Copyright © 2013 John Wiley & Sons, Ltd.
Chrysin inhibits metastatic potential of human triple‐negative breast cancer cells by modulating matrix metalloproteinase‐10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway
Authors: Yang Bing , Huang Jing , Xiang Tingxiu , Yin Xuedong , Luo Xinrong , Huang Jianbo , Luo Fuling , Li Hongyuan , Li Hongzhong , Ren Guosheng 
Published: October 2013

ABSTRACTChrysin, a naturally occurring flavone, has been shown to inhibit cell proliferation and induce cell apoptosis in various cancers. However, the effect and mechanisms of chrysin on cancer metastasis are still enigmatic. In this study, metastatic triple‐negative breast cancer (TNBC) cell lines were used to evaluate the antimetastatic activity of chrysin. The results showed that chrysin (5, 10 and 20 μM) significantly suppressed TNBC cell migration and invasion in a dose‐dependent manner. Human matrix metalloproteinase (MMP) antibody array demonstrated that MMP‐10 was downregulated by chrysin, which was further verified by Western blotting and ELISA. Moreover, it was shown that chrysin induced increased E‐cadherin expression and decreased expression of vimentin, snail and slug in TNBC cells, suggesting that chrysin had a reversal effect on epithelial–mesenchymal transition. More importantly, it was demonstrated that inhibiting the Akt signal pathway might play a central role in chrysin‐induced antimetastatic activity by regulating MMP‐10 and epithelial–mesenchymal transition. In conclusion, our study indicates that chrysin exerts antimetastatic activities in TNBC cells, which suggests that chrysin might be a potential therapeutic candidate for the treatment of advanced or metastatic breast cancer. Copyright © 2013 John Wiley & Sons, Ltd.