bluuebunny/crossref_metadata_2025_split huggingface dataset:
NRASQ61R‐driven atypical melanocytic tumor with blue nevus‐like morphology: A case report
Authors: Hiraki Tsubasa , Mori Hiroki , Misawa Junko , Yunoki Marina , Goto Keisuke 
Published: August 2024

AbstractNRAS Q61 mutations are driver genetic alterations associated with common melanocytic nevi. Herein, we describe a case of NRAS‐mutant melanocytic tumor with a blue nevus‐like morphology. A 71‐year‐old Japanese man presented with a 4.6‐mm nodule on his back. Histopathological examination revealed a dense distribution of spindle‐shaped melanocytes in the upper dermis and a sparse distribution of dendritic melanocytes in the mid‐dermis. The vertical periadnexal extension reached the deep dermis at the center of the tumor. A small junctional component, hyperpigmentation, sclerotic stroma, mild nuclear atypia, and a few mitotic figures were observed. Immunohistochemical examination revealed no PRAME expression and preserved p16 expression. Diffuse RASQ61R immunoreactivity was observed in these tumor cells. Nuclear β‐catenin expression was not observed. Targeted RNA sequencing revealed two mutations, NRAS c.182A>G (Q61R) and FGFR2 c.‐157A>G, but no other pathogenic alterations such as BRAF, GNAQ, GNA11, CTNNB1, PRKAR1A, or IDH1 mutations or kinase gene fusions. The histopathology fits that of compound‐type blue nevus, which is called “Kamino nevus”; however, this tumor was genetically considered to be on the spectrum of conventional acquired melanocytic nevi but not on that of blue nevi. Morphologically, NRAS‐driven melanocytic nevi resemble blue nevi without IDH1R132C coexistence.
Mental load at the intersection of migration, motherhood and work
Authors: Dwivedi Priyanka , Kapoor Bhavya , Vahia Manasi 
Published: August 2024

AbstractThis paper investigates the narratives of Mental load (ML) within the realm of migration. The study captures the migration experiences of three Indian mother‐workers across their journey of migration. By examining the ML situated at the intersection of migration, motherhood, and paid work, our study bridges the theoretical gap at the micro level by understanding how skilled Indian mother‐workers manufacture subjectivities as they now spend their lives in Australia and Canada. We define ML in the context of migration and explore how these women navigate the newness of identity, cultural adaptation, and reframe mothering, all while juggling their ML accompanying the unfamiliarity of mobility. Further, we demonstrate how migrant mothers understand themselves diversely in relation to their careers in the new land. We find that ML ascends in the beginning of the journey. Further, the research unveils that the mother‐workers agentically modulate their ML with a clear and well‐defined migration objective as the guiding beacon in steering through the subsequent migration journey. Moreover, the absence of clarity in migration objectives substantially augments the ML. These results hold significance in the conceptualization of migration‐related ML of mother‐workers, hence offering a subjective lens to capture the everyday portrait of a migrant mother‐worker.
MACRO UNCERTAINTY, UNEMPLOYMENT RISK, AND CONSUMPTION DYNAMICS
Authors: Oh Joonseok , Rogantini Picco Anna 
Published: August 2024

AbstractHouseholds' income heterogeneity is important to explain consumption dynamics in response to aggregate macro uncertainty: an increase in uncertainty generates a consumption drop that is stronger for lower‐income households. At the same time, labor markets are strongly responsive to macro uncertainty. A heterogeneous‐agent New Keynesian model with search‐and‐matching frictions in the labor market can account for these empirical findings. The mechanism at play is a feedback loop between lower‐income households who, being subject to higher unemployment risk, contract consumption more in response to heightened uncertainty, and firms that post fewer vacancies following a drop in demand.
Bayesian estimates of genetic parameters for growth traits in Harnali sheep
Authors: Dash Spandan Shashwat , Bangar Yogesh C. , Magotra Ankit , Patil C. S. , Sharma Rohit , Chauhan Ashish , Dahiya S. P. 
Published: August 2024

AbstractThe objective of the study was to estimate genetic parameters of the growth traits under Bayesian inference in Harnali sheep. The information of pedigree and targeted traits of 2404 Harnali animals born to 159 sires and 695 dams was collected for the period from 1998 to 2021. The growth traits included weight at birth (BWT), 3 (WWT), 6 (6WT) and 12 (YWT) months of age. The genetic evaluation was carried out using six univariate animal models comprising direct and maternal effects using THRGIBBS1F90 and POSTGIBBSF90 programs. The fixed factors adjusted in the analysis were period of birth, sex of lamb and dam's weight at lambing. Bayesian estimates of direct heritability under best model for BWT, WWT, 6WT and YWT traits were 0.16 ± 0.04, 0.10 ± 0.04, 0.18 ± 0.04, and 0.05 ± 0.03, respectively. The significant maternal influences observed for BWT and WWT traits with 9% and 8% contribution to total phenotypic variances, respectively. Additionally, maternal permanent environmental influences were observed to BWT (4%) and YWT trait (3%). The genetic and phenotypic correlations among studied traits were high and positive. The genetic changes were positive and significant for WWT only. It was concluded that the weight at 6 months of age can be continued as selection criterion for further genetic improvement through selection. Also, maternal effects should be considered in breeding programme for enhancing early growth performance in Harnali sheep.
Raddeanin A augments the cytotoxicity of natural killer cells against chronic myeloid leukaemia cells by modulating MAPK and Ras/Raf signalling pathways
Authors: Hsieh Ming‐Ju , Lin Jen‐Tsun , Chuang Yi‐Ching , Lo Yu‐Sheng , Lin Chia‐Chieh , Ho Hsin‐Yu , Chen Mu‐Kuan 
Published: August 2024

AbstractNatural killer (NK) cell therapy, a developing approach in cancer immunotherapy, involves isolating NK cells from peripheral blood. However, due to their limited number and activity, it is essential to significantly expand these primary NK cells and enhance their cytotoxicity. In this study, we investigated how Raddeanin A potentiate NK activity using KHYG‐1 cells. The results indicated that Raddeanin A increased the expression levels of cytolytic molecules such as perforin, granzymes A and granzymes B, granulysin and FasL in KHYG‐1 cells. Raddeanin A treatment increased CREB phosphorylation, p65 phosphorylation, NFAT1 and acetyl‐histone H3 expression. Raddeanin A elevated caspase 3 and PARP cleavage, increased t‐Bid expression, promoting apoptosis in K562 cells. Furthermore, it reduced the expression of HMGB2, SET and Ape1, impairing the DNA repair process and causing K562 cells to die caspase‐independently. Additionally, Raddeanin A increased ERK, p38 and JNK phosphorylation at the molecular level, which increased granzyme B production in KHYG‐1 cells. Raddeanin A treatment increased Ras, Raf phosphorylation, MEK phosphorylation, NKG2D, NKp44 and NKp30 expression in KHYG‐1 cells. Collectively, our data indicate that Raddeanin A enhances the cytotoxic activity of NK cells against different cancer cells.
Lycorine (Lycoris radiata)—a unique natural medicine on breast cancer
Authors: Xue Qinbing , Wang Bing , Feng Jie , Li Chaoyu , Yu Miao , Zhao Yan , Qi Zheng 
Published: August 2024

AbstractBreast cancer (BC) is one of the most common types of cancer among women worldwide. Lycorine (Lycoris radiata), a small molecule derived from the traditional Chinese herb Amaryllidaceae plants, has appeared potential effect on inhibiting the growth of cancer cells and inducing apoptosis in various types of cancer with minor side effects. To discuss the therapeutic effects and molecular mechanisms of lycorine on BC established by lycorine‐treated S180 tumour‐bearing mice in vivo. Furthermore, both the mitotic and microtubule assembly dynamics genes were performed by qPCR assays, and the protein expression associated with mitotic arrest was investigated by western blot. Lycorine was demonstrated to reduce sarcoma growth of S180 tumour‐bearing mice and inhibit the proliferation of MCF‐7 cells in concentration‐dependent manner. Moreover, lycorine induced M phase cell cycle arrest via interfering with the mitotic apparatus regulated the expression of 20 genes and 15 proteins in cell cycle progression. Furthermore, this study confirmed that the potential effect of lycorine on BC might be mediated by cell cycle arrest in M phase for the first time. These results would be the consequence of exploitation of lycorine as a potential drug for BC therapy, however further preclinical and clinical studies are still needed.
“Doing the right thing”: Moral conflicts and ethical issues experienced by military nurses during wartime
Authors: Agazio Janice , Padden Diane L. 
Published: August 2024

AbstractIntroductionThe War on Terrorism, which included Operation Enduring Freedom (OEF) in Afghanistan from 2001 to 2014 and the concurrent Operation Iraqi Freedom (OIF) from 2003 to 2011, exposed military nurses to situations and challenges for which many reported feeling unprepared. Clinically, nurses faced multi‐trauma injuries and devastating wounds suffered by military troops and civilians alike. Cultural issues and harsh living conditions added further complications to the care environment. The purpose of this study was to address the research question: How do military nurses identify, assess, manage, and personally resolve ethical issues occurring in nursing practice during wartime deployments?DesignQualitative grounded theory provided the design for this study.MethodsUsing the constant comparative method, data collection, and data analysis occurred simultaneously to build a theory of ethical issues management during wartime. Using a focused interview guide responsive to emerging themes and developing theory, interviews were conducted until theoretical saturation was achieved. Participants represented primarily Army (55%) active duty (83%) female nurses (71%) who had deployed to Iraq (52%), Afghanistan (32%), or both (16%). A sampling grid was used to recruit nurses representative of the demographics deployed in support of OIF and OEF. Data analysis used grounded theory methods to identify a core construct to detail proposed relationships and concepts. Rigor was maintained in study methods and analysis using established tenets to support trustworthiness.ResultsThe nurses shared stories regarding their experiences during deployment. Many struggled to find internal resolutions regarding the care of detainees, cultural differences, end‐of‐life decision‐making, pain management, and care of civilian casualties.ConclusionThe study described the ethical issues military nurses encountered during wartime and the strategies used to mitigate moral conflict. By better understanding how nurses define, assess, and manage ethical situations, we can better prepare our deploying nurses for future conflicts.Clinical RelevanceMilitary nurses returning from wars with unresolved moral conflicts are at risk for moral distress. Moral distress has been associated with burnout, dissatisfaction with and leaving the nursing profession, compassion fatigue, and disinterest in the provision of quality patient care. In the interest of preserving the health of military nurses, steps need to be taken to provide resources for helping them prepare for, encounter, and cope with the ethical situations inherent in wartime nursing care.
Efficacy and safety of non‐cross‐linked hyaluronic acid compound in the treatment of keratosis pilaris: A split‐body randomized clinical trial
Authors: Li Yao , Wang Shi‐Wei , Liu Yan‐Hua , Zou Mu‐Yan , Wu Jia‐Xu , Luo Sheng‐Kang , Hong Wei‐Jin 
Published: August 2024

AbstractBackgroundKeratosis pilaris (KP) is a prevalent benign dermatological condition characterized by small bumps at the hair follicles alongside surrounding redness, significantly impacting both aesthetics and mental well‐being.ObjectiveThis study investigated the potential benefits of a non‐cross‐linked hyaluronic acid (HA) compound for treating KP.MethodsA split‐body, investigator‐blinded, randomized, intraindividual comparative clinical trial was conducted. The non‐cross‐linked HA compound was injected into KP‐affected regions on both upper arms. The treatment was delivered across four sessions scheduled at 4‐week intervals. Blinded physicians and patients assessed differences in erythema, skin roughness, and overall scores between treated and control areas at the final follow‐up visit. At the 12th and 24th weeks post‐treatment, a four‐point scale was utilized to assess subjects' perceived treatment efficacy. Additionally, dermoscopic images, histological alterations, and adverse events were monitored.ResultsPhysician assessments revealed a significant reduction in roughness and overall scores for treated areas compared to controls. Patient self‐assessments also reflected improvements in roughness, redness, and overall scores for treated sides at the final visit, with 35.71% of patients demonstrating sustained improvement in redness and 71.43% reporting persistent improvements in roughness at 24th weeks post‐treatment. The dermatoscopic examinations revealed a notable enhancement in both the quantity of follicular plugs and the extent of erythema among the subjects in the treatment group. Histopathological outcomes also demonstrated improvement.ConclusionThis study suggests that the non‐cross‐linked HA compound effectively improves skin roughness and promotes hair shaft growth in KP treatment, demonstrating a favorable safety profile. These findings position it as a potentially viable alternative therapy in clinical practice.
Serum glial fibrillary acidic protein as a marker of brain MRI metrics in multiple sclerosis: A scoping review
Authors: Marini Noah , Lesack Nikolai , Alizadeh Sama , Kani Aliya , Kitchin Vanessa , Vavasour Irene M. , Laule Cornelia 
Published: August 2024

AbstractBackground and PurposeMagnetic resonance imaging (MRI) is heavily relied upon for the diagnosis and monitoring of multiple sclerosis (MS), a chronic, demyelinating disease of the central nervous system. Serum biomarkers may serve as an accessible tool for increasing sensitivity, improving accessibility, corroborating symptoms, and providing additional data to guide clinical management. This scoping review investigates the current understanding of how the serum biomarker glial fibrillary acidic protein (sGFAP) relates to brain MRI metrics.MethodsWe adhered to the Joanna Briggs Institute methodology for scoping reviews and the Preferred Reporting Items for Systematic reviews and Meta‐Analyses guidelines. The databases Medline (Ovid), Embase (Ovid), CINAHL (Ebsco), and Web of Science (University of British Columbia institutional access) were searched on August 24, 2023 using a combination of medical subject headings and keyword terms for the topic of serum biomarkers in MS.ResultsA total of 9880 articles were retrieved in total of which 6271 unique titles and abstracts were screened. Twelve of the 259 resultant papers contained sGFAP data and proceeded to extraction. It was found that lesion MRI metrics generally had a positive relationship with sGFAP, while gray matter and white matter metrics, including normal‐appearing white matter, were related negatively or not at all.ConclusionsThese results highlight that while sGFAP may not be specific for MS, it may have utility for increasing sensitivity in postdiagnosis monitoring of MS progression.
A new stem‐group mantispoid lineage (Insecta: Neuroptera) equipped with unique raptorial structures from the Middle Jurassic of China
Authors: Wang Jinglei , Shi Chaofan , Liu Xingyue , Shih Chungkun , Ren Dong , Wang Yongjie 
Published: August 2024

AbstractDuring the Cretaceous period, the lacewing superfamily Mantispoidea, with an assemblage of species possessing raptorial forelegs, have undergone a rapid species radiation, characterized by abundant species richness and high morphological plasticity. Nevertheless, the morphology and early evolution of the specialized predatory organ around the time of its origin in raptorial Mantispoidea have been poorly documented due to the rarity of fossil evidence, especially for the pre‐Cretaceous fossils. Herein, a new genus and new species, that is Archarhachiberotha longitarsa Wang, Ren et Wang gen. et sp. nov., was described from the Middle Jurassic Jiulongshan Formation of northeastern China. This new genus was characterized by the remarkable raptorial forelegs, that is, typically elongated coxa, relatively less‐swollen femur and rudimentary small femoral spines, and well‐developed tarsi. Considering the peculiar morphological combination and antiquity of the new genus, it was assigned to be a stem‐group lineage of Mantispoidea. Also, the detailed analyses of morphology and biological functions of raptorial forelegs were made to conclude that the new genus evolved into an unknown but primitive raptorial type that was distinctly different from the extant morphological features and raptorial mechanisms. In addition, the evolutionary tendency of raptorial Mantispoidea herein summarized highlights morphological diversity and disparity between fossil and extant representatives, and provides a rare case to explore the entire evolutionary history of a specialized structure in one lineage.
Multi‐view street view image fusion for city‐scale assessment of wind damage to building clusters
Authors: Gu D. L. , Shuai Q. W. , Zhang N. , Jin N. , Zheng Z. X. , Xu Z. , Xu Y. J. 
Published: August 2024

AbstractGlobal warming amplifies the risk of wind‐induced building damage in coastal cities worldwide. Existing numerical methods for predicting building damage under winds have been limited to virtual environments, given the prohibitive costs associated with establishing city‐scale window inventories. Hence, this study introduces a cost‐effective workflow for wind damage prediction of real built environments, where the window inventory can be established with the multi‐view street view image (SVI) fusion and artificial intelligence large model. The feasibility of the method is demonstrated based on two real‐world urban areas. Notably, the proposed multi‐view method surpasses both the single‐view and aerial image‐based methods in terms of window recognition accuracy. The increasing availability of SVIs opens up opportunities for applying the proposed method not only in disaster prevention but also in environmental and energy topics, thereby enhancing the resilience of cities and communities from multiple perspectives.
Genome‐Wide Association Study Reveals Candidate Genes Controlling Tillering and Effective Panicle Number in Rice (Oryza sativa L.)
Authors: Li Yuhong , Shi Wei , Zhu Shuhao , Yu Ling , Cai Yue , Wang Zhiping , Liu Jianju , Wu Yunyu , Pan Cunhong , Chen Zichun , Zhou Changhai , Ji Hongjuan , Huang Niansheng , Zhang Xiaoxiang , Gao Peng , Jiao Jun , Xiao Ning , Li Aihong 
Published: August 2024

ABSTRACTTiller number and effective panicle number are important factors affecting rice yield. In this study, the sequencing data of 331 rice varieties were used to carry out genome‐wide association study (GWAS) of these two factors. A total of 58 candidate genes related to tiller number were identified, and their functions involved energy metabolism and cytoplasmic membrane metabolism pathways. There were 19 candidate genes related to effective panicle number, whose functions involved energy metabolism, cytoplasmic membrane metabolism and signal transduction pathways. A new QTL ‘qTNP12’, which controls both tiller number and effective panicle number, was identified on chromosome 12. There was specific variation in the 275th amino acid in the coding frame of the candidate gene. Indica rice with multiple tillers had histidine variation, while japonica rice with few tillers and Oryza rufipogon had arginine variation. Evolutionary analysis showed that the multi‐tiller trait of indica rice was developed through artificial selection and domestication. The results of this study provide a foundation for further clarifying the molecular mechanism of qTPN12 regulating tiller and effective panicle, as well as improving rice architecture through molecular marker‐assisted selection.
Applying the “SOTEC” framework of sociotechnical risk analysis to the development of an autonomous robot swarm for a public cloakroom
Authors: Winter Peter , Downer John , Wilson James , Abeywickrama Dhaminda B. , Lee Suet , Hauert Sabine , Windsor Shane 
Published: August 2024

AbstractThe past decade has seen efforts to develop new forms of autonomous systems with varying applications in different domains, from underwater search and rescue to clinical diagnosis. All of these applications require risk analyses, but such analyses often focus on technical sources of risk without acknowledging its wider systemic and organizational dimensions. In this article, we illustrate this deficit and a way of redressing it by offering a more systematic analysis of the sociotechnical sources of risk in an autonomous system. To this end, the article explores the development, deployment, and operation of an autonomous robot swarm for use in a public cloakroom in light of Macrae's structural, organizational, technological, epistemic, and cultural framework of sociotechnical risk. We argue that this framework provides a useful tool for capturing the complex “nontechnical” dimensions of risk in this domain that might otherwise be overlooked in the more conventional risk analyses that inform regulation and policymaking.
Conceptualizing social risk in relation to climate change and assisted ecosystem adaptation
Authors: Lockie Stewart , Graham Victoria , Taylor Bruce , Baresi Umberto , Maclean Kirsten , Paxton Gillian , Vella Karen 
Published: August 2024

AbstractRealizing positive social and environmental outcomes from assisted ecosystem adaptation requires the management of complex, uncertain, and ambiguous risks. Using assisted coral reef adaptation as a case study, this article presents a conceptual framework that defines social impacts as the physical and cognitive consequences for people of planned intervention and social risks as potential impacts transformed into objects of management through assessment and governance. Reflecting on its multiple uses in the literature, we consider “social risk” in relation to risks to individuals and communities, risks to First Peoples, risks to businesses or project implementation, possibilities for amplified social vulnerability, and risk perceptions. Although much of this article is devoted to bringing clarity to the different ways in which social risk manifests and to the multiple characters of risk and uncertainty, it is apparent that risk governance itself must be an inherently integrative and social process.