bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Reservoir Characterization and Simulation With Near-Wellbore Modeling
Authors: Chandra V.. , Corbett P.W.M.. W.M. , Geiger S.. , Hamdi H.. 
Published: April 2013

SummaryNew reservoir characterization methods are needed to integrate multiscale exploration and development data, particularly at the interface between well and field models. In this paper, we illustrate a novel workflow involving high-resolution near-wellbore modeling (NWM), which allows us to accurately include seismic, wireline data, image logs, and well core logs from highly heterogeneous reservoirs in field-scale reservoir simulations. We demonstrate that an NWM-enhanced geoengineering workflow has the potential to improve reservoir characterization by applying it to a realistic clastic reservoir with high variance at small scale. We have performed a number of sensitivities comparing conventional local grid refinement (LGR) in the near-wellbore region with that involving NWM, and we obtained a significant increase in the accuracy of reservoir characterization and the calibration of dynamic models. Centimeter-scale models, containing several million cells, representing the fine geological details of the near-wellbore region, were constructed with available data from core and openhole well-log suits. The resulting well models were upscaled into regular grids with the highest resolution possible through the NWM software and incorporated into a field-scale simulation model to evaluate the dynamic behavior of the reservoir with a static-model transient test. Our results show that the use of NWM tools for reservoir modeling yields more precise flow calculations and improves our fundamental understanding of the interactions between the reservoir and the wellbore.
On the generating function e
xt+yϕ(t) and its fractional calculus
Authors: Ansari Alireza , Sheikhani Amirhossein , Kordrostami Sohrab 
Published: April 2013

Abstract
In this article, we derive the coefficient set {H
m(x,y)}m=1∞ using the generating function ext+yϕ(t). When the complex function ϕ(t) is entire, using the inverse Mellin transform, and when ϕ(t) has singular points, using the inverse Laplace transform, the coefficient set is obtained. Also, bi-orthogonality of this set with its associated functions and its applications in the explicit solutions of partial fractional differential equations is discussed.
Pharmacokinetic Interactions between Lersivirine and Zidovudine, Tenofovir Disoproxil Fumarate/ Emtricitabine and Abacavir/Lamivudine
Authors: Vourvahis Manoli , Davis John , Langdon Grant , Layton Gary , Fang Juanzhi , Choo Heng Wee , Hansson Arne G , Tawadrous Margaret 
Published: April 2013

Background To investigate pharmacokinetic interactions associated with coadministration of lersivirine with zidovudine, tenofovir disoproxil fumarate (DF)/emtricitabine (Truvada®) or abacavir/lamivudine (Epzicom®/Kivexa®). Methods Three Phase I, open, crossover studies with two (studies 1 and 3) or three (study 2) treatment periods were conducted in healthy individuals. In study 1, individuals received zidovudine and placebo or zidovudine and lersivirine on days 1–14. In study 2, individuals received lersivirine and tenofovir DF/emtricitabine, lersivirine and placebo or tenofovir DF/emtricitabine and placebo on days 1–10. In study 3, individuals received abacavir/ lamivudine only in period 1 (5 days) and abacavir/lamivudine and lersivirine in period 2 (10 days). Blood samples were taken on days 1–14 (study 1) or day of final dose (studies 2 and 3) and analysed using high performance liquid chromatography/dual mass spectrometry. Pharmacokinetic parameters were calculated by standard non-compartmental methods. Results When coadministered with lersivirine, zidovudine exposure increased by 35%, and exposure of its metabolite zidovudine-glucuronide decreased by 19%. Following coadministration of lersivirine and tenofovir DF/emtricitabine, tenofovir exposure increased by 30%, and lersivirine exposure decreased by 12%. Coadministration of lersivirine and abacavir/lamivudine increased abacavir exposure by 27% and decreased lamivudine exposure by 8%. Adverse events were predominantly mild in these Phase I studies. Conclusions Coadministration of lersivirine with zidovudine, tenofovir DF/emtricitabine or abacavir/lamivudine influenced the systemic exposure of all nucleoside reverse transcriptase inhibitor agents investigated (except for lamivudine; emtricitabine pharmacokinetics were not assessed). Changes were not considered clinically meaningful for zidovudine and abacavir. The clinical relevance of the effect on tenofovir pharmacokinetics is currently unknown.
Faldaprevir (Bi 201335), Deleobuvir (Bi 207127) and Ribavirin Oral Therapy for Treatment-Naive HCV Genotype 1: Sound-C1 Final Results
Authors: Zeuzem Stefan , Asselah Tarik , Angus Peter , Zarski Jean-Pierre , Larrey Dominique , Müllhaupt Beat , Gane Ed , Schuchmann Marcus , Lohse Ansgar W , Pol Stanislas , Bronowicki Jean-Pierre , Roberts Stuart , Arasteh Keikawus , Zoulim Fabien , Heim Markus , Stern Jerry O , Nehmiz Gerhard , Kukolj George , Böcher Wulf O , Mensa Federico J 
Published: April 2013

Background Faldaprevir (BI 201335) and deleobuvir (BI 207127) are direct-acting antiviral agents under development for the treatment of chronic HCV infection. This article describes the final results of the Phase Ib SOUND-C1 study that evaluated the interferon-free oral combination of faldaprevir, deleobuvir and ribavirin in 32 treatment-naive patients infected with HCV genotype 1. Methods Patients were randomized to receive deleobuvir 400 mg ( n=15) or 600 mg ( n=17) three times daily plus faldaprevir 120 mg once daily and weight-based ribavirin for 4 weeks. Interferon-free therapy was followed by response-guided faldaprevir plus pegylated interferon-α2a/ribavirin to week 24 or 48. Results At week 4, 73% (11/15) and 100% (17/17) of patients in the deleobuvir 400 mg and 600 mg groups achieved HCV RNA<25 IU/ml, respectively. During interferon-free treatment, virological breakthrough was reported in one patient and re-increase of HCV RNA in one patient. Both patients were successfully treated with interferon-containing therapy. The rate of sustained virological response 24 weeks after completion of treatment was 73% (11/15) in the deleobuvir 400 mg group and 94% (16/17) in the 600 mg group. During faldaprevir plus pegylated interferon-α2a/ ribavirin treatment, the most common adverse events were pruritus (38% of patients), rash (31%) and asthenia (31%); these were severe in approximately 3% of patients. Conclusions Potent antiviral activity and favourable safety of the treatment regimen were demonstrated. Furthermore, the results suggest that patients with breakthrough at week 4 may be rescued with an interferon-containing regimen. Clinical trials.gov number NCT01132313.
La guerre : un stimulant économique ? Bordeaux et la guerre de la Ligue d'Augsbourg, 1688-1697
Authors: Le Mao Caroline 
Published: April 2013

Si l’on mesure assez bien les effets néfastes qu’a pu avoir la guerre de la Ligue d’Augsbourg sur le commerce bordelais, on ignore généralement le fait qu’à la même époque, la marine de guerre, dont les consommations allèrent croissant, s’approvisionna dans la cité de Guyenne, par l’intermédiaire du commissaire général de la marine, Lombard. L’étude de 191 contrats passés par celui-ci, au nom du roi, entre 1688 et 1697 nous permet d’esquisser le rôle que Bordeaux a pu jouer dans l’approvisionnement de la marine de guerre durant ce conflit et de préciser la structuration de ce commerce, la nature des marchandises échangées et les intervenants.
Reconstruire après une catastrophe : la Nouvelle-Orléans après l'ouragan Katrina et les villes européennes après les bombardements
Authors: Diefendorf Jeffry M. 
Published: April 2013

Après que l’ouragan Katrina eut infligé des dégâts sérieux à la Nouvelle-Orléans en août 2005, citoyens, journalistes, et urbanistes partout aux États-Unis se focalisèrent sur la reconstruction de la ville. Beaucoup de gens firent le rapprochement entre cette catastrophe naturelle et la destruction des villes bombardées pendant la Seconde Guerre Mondiale, et, comme bien d’urbanistes après la guerre, ils se félicitèrent de cette occasion de construire une nouvelle ville, supérieure à la précédente. On réclama immédiatement un nouveau « plan Marshall » afin de faire financer le projet par le gouvernement fédéral. Cet article examine les similitudes et les différences entre la reconstruction des villes allemandes après 1945 et la Nouvelle-Orléans après Katrina. Il explore les différents modes de financement, les types de propositions que génèrent les urbanistes, et la nature du processus de planification.
The Effects of Mitomycin C on Tear Function After Photorefractive Keratectomy: A Contralateral Comparative Study
Authors: Farahi Azadeh , Hashemi Hassan , Mehravaran Shiva 
Published: April 2013

PURPOSE:
To assess the effects of adjuvant mitomycin C (MMC) on tear function tests after photorefractive keratectomy (PRK) for myopia.

METHODS:
In this prospective, randomized, double-blind study, one eye of myopic patients undergoing PRK was randomly chosen for PRK and the other eye was treated with PRK plus the application of 0.02% MMC for 20 seconds onto the ablated stroma. All patients had corneal esthesiometry, fluorescein break-up time testing, fluorescein and Rose Bengal staining, and Schirmer testing with anesthesia, and they also completed a questionnaire preoperatively and at 1.5, 3, 6, and 12 months after surgery.

RESULTS:
Twenty-seven patients with a mean age of 25 ± 3.27 years were enrolled. There were no statistically significant differences between the PRK and PRK+MMC groups regarding the symptoms and tear function tests preoperatively or at any postoperative follow-up visit. Preoperative and postoperative results in the total sample were also compared; statistically significantly different results were observed in fluorescein break-up time and dry eye symptoms at 1.5 months, which showed improvement thereafter. Corneal sensation was significantly lower at all postoperative follow-up visits compared with preoperative results.

CONCLUSIONS:
The intraoperative use of MMC during PRK did not induce tear deficiency, and it seems that MMC can be used safely when necessary.

[
J Refract Surg.
2013;29(4):260–264.]
A 3-Month Jump-Landing Training Program: A Feasibility Study Using the RE-AIM Framework
Authors: Aerts Inne , Cumps Elke , Verhagen Evert , Mathieu Niels , Van Schuerbeeck Sander , Meeusen Romain 
Published: April 2013

Context:Evaluating the translatability and feasibility of an intervention program has become as important as determining the effectiveness of the intervention.Objective:To evaluate the applicability of a 3-month jump-landing training program in basketball players, using the RE-AIM (reach, effectiveness, adoption, implementation, and maintenance) framework.Design:Randomized controlled trial.Setting:National and regional basketball teams.Patients or Other Participants:Twenty-four teams of the second highest national division and regional basketball divisions in Flanders, Belgium, were randomly assigned (1:1) to a control group and intervention group. A total of 243 athletes (control group = 129, intervention group = 114), ages 15 to 41 years, volunteered.Intervention(s):All exercises in the intervention program followed a progressive development, emphasizing lower extremity alignment during jump-landing activities.Main Outcome Measure(s):The results of the process evaluation of the intervention program were based on the 5 dimensions of the RE-AIM framework. The injury incidence density, hazard ratios, and 95% confidence intervals were determined.Results:The participation rate of the total sample was 100% (reach). The hazard ratio was different between the intervention group and the control group (0.40 [95% confidence interval = 0.16, 0.99]; effectiveness). Of the 12 teams in the intervention group, 8 teams (66.7%) agreed to participate in the study (adoption). Eight of the participating coaches (66.7%) felt positively about the intervention program and stated that they had implemented the training sessions of the program as intended (implementation). All coaches except 1 (87.5%) intended to continue the intervention program the next season (maintenance).Conclusions:Compliance of the coaches in this coach-supervised jump-landing training program was high. In addition, the program was effective in preventing lower extremity injuries.
Acetabular Revision Arthroplasty: Using the Hastings Bipolar Head to Enable Retention of a Well-Fixed Monoblock Stem
Authors: McLoughlin Louise , Leonard Michael , Curtin William 
Published: April 2013

We describe a novel technique of combining the Hastings bipolar head, matched in size to the acetabular cup liner, with a fixed, cemented monoblock stem allowing for isolated uncemented acetabular revision arthroplasty. Aim To assess patient clinical and radiological outcomes after isolated uncemented acetabular revision arthroplasty using the Hastings bipolar head. Methods Clinical outcome was assessed with the Oxford and WOMAC hip scores. Radiographs were assessed pre-operatively for acetabular defects. Post operative osseointegration of the acetabular cup was then classified and the femoral stem was examined for signs of loosening. Results Nine acetabular components were revised in eight patients. Pre-Operative acetabular defects ranged from Paprosky type 1 to 3A. There were no significant intra or postoperative complications. At a mean final follow-up of 15 months, the Oxford hip score improved from an average of 17.5 pre-operatively to 44.1, and the WOMAC score had improved from 44.1 to 90.9. Eight acetabular cups demonstrated three or more signs of osseointegration with the remaining cup showing two signs. There were no signs of loosening of the retained femoral stems. Conclusion These short term results of the use of the Hastings bipolar head in isolated uncemented acetabular revision arthroplasty demonstrate good patient outcomes, reduced morbidity, decreased technical difficulties for the surgeon and reduced expense for the health service.
Recentering Pedagogy in an Age of Narcissism
Authors: Watters Ann O. 
Published: April 2013

Abstract
In contrast to the reciprocal altruism that fostered early humankind, an unintended consequence of student-centered pedagogy may be its contribution to the narcissism pervading society generally and recent college cohorts specifically. Educators should claim appropriate authority, discourage inappropriate entitlement, and encourage empathy, service to others, and decentered perspectives.
Suicide et alimentation : approche biopsychosociale
Authors: Desseilles François , Mikolajczak Gladys , Desseilles Martin 
Published: April 2013

Cet article propose un éclairage biopsychosocial des liens entre la santé mentale, plus particulièrement le suicide, et l’alimentation. Premièrement, nous développons les liens entre l’alimentation, son rôle social et le suicide. L’acte alimentaire est étudié en tant qu’intégrateur et régulateur social, à la lumière de la théorisation de Durkheim. L’alimentation est également envisagée comme autodestruction, avec le cas particulier du « suicide alimentaire ». La déstructuration des repas et les aliments aliénants sont identifiés comme facteurs contribuant à la déstructuration des « modèles alimentaires ». Ensuite, nous évoquons la place de l’alimentation dans la psychopathologie et enfin, les liens entre les paramètres biologiques reflétant l’alimentation et le risque de suicide. Des pistes de recherche et d’intervention découlant de l’approche biopsychosociale proposée dans cet article sont également proposées.
L’apport de la recherche en psychologie dans la compréhension complexe de l’étiologie du suicide
Authors: Séguin Monique , Di Mambro Mélanie , Desgranges Annie 
Published: April 2013

Si la présence de certains facteurs augmente le risque de conduites suicidaires, la question est de savoir quel peut être le poids différentiel des divers facteurs de risque, pour quels individus, dans quel contexte et à quelle période de leur vie ? Nous avons mis à l’épreuve l’expérimentation d’un modèle expliquant différentes trajectoires de vie qui mènent au suicide. Cette étude permet de dépasser un modèle corrélationnel d’identification de facteurs de risque et de cibler quatre sous-groupes distincts d’individus dont la trajectoire développementale semble bien différente. Il est clair que le suicide est un problème complexe, multidimensionnel, multiniveau. La psychologie, au carrefour de plusieurs disciplines scientifiques, peut intégrer et faire le lien avec d’autres disciplines afin de clarifier les contextes de vie qui affectent différemment les personnes suicidaires, permettant ainsi de mettre en oeuvre des interventions préventives susceptibles d’agir dans cette chaîne causale dont l’issue ultime est le suicide.
Le suicide de la personne âgée : existe-t-il des spécificités liées à l’âge ?
Authors: Richard-Devantoy Stéphane , Jollant Fabrice 
Published: April 2013

Le suicide de la personne âgée pose la question de notre relation à la vieillesse et à la mort. Significativement lié à la dépression, il est relativement élevé dans cette tranche d’âge. Les conduites suicidaires de la personne âgée présentent des particularités cliniques : une intentionnalité et une létalité suicidaire élevées, peu d’antécédents personnels de conduites suicidaires et un faible niveau d’impulsivité et d’agressivité. La vulnérabilité suicidaire pourrait reposer sur des mécanismes étiopathogéniques à la fois communs et différents selon l’âge. Par exemple, il y aurait une prépondérance des facteurs développementaux précoces marqués par de l’impulsivité et de l’agressivité chez l’adolescent et le jeune adulte ; chez l’adulte âgé, il y aurait un vieillissement pathologique. Des déficits neurocognitifs similaires conduisent le sujet à ne pas pouvoir répondre adéquatement à son environnement, différent selon l’âge. La comparaison directe des sujets jeunes et âgés est nécessaire pour comprendre la genèse de la vulnérabilité suicidaire. Nous conclurons cet article avec un résumé des principes de reconnaissance et de prise en charge du risque suicidaire.
Changes in maternal secretory immunoglobulin a levels in human milk during 12 weeks after parturition
Authors: Kawano Atsuko , Emori Yoko 
Published: April 2013

BackgroundImmune factors in human milk change in concentration after delivery. However, this concentration change during the early postpartum period has not yet been investigated in detail.MethodsWe measured Secretory IgA (SIgA) levels in the human milk of 91 postpartum mothers (after vaginal delivery) by using an enzyme immunoassay, in postpartum day 3, and weeks 1, 2, 3, 4, 8, and 12.ResultsThe SIgA concentration gradually declined over the 12‐week period, with the highest level recorded in day 3. At week 4, the SIgA levels decreased to half the initial levels. Although the difference in concentration from one week to the next was remarkable, the decrease in concentration was rapid in the first 4 weeks but gradual from week 4 to week 12.ConclusionsThe SIgA levels gradually decreased up to week 12. However, the concentration of SIgA in breast milk did not change constantly. It changed relatively rapid until 4 weeks after childbirth, and because the concentration from the third day to the eighth week became 50%, it was understood that the change was temporal. Am. J. Hum. Biol. 25:399–403, 2013. © 2013 Wiley Periodicals, Inc.
25‐hydroxyvitamin D levels in African American and Nigerian women
Authors: Durazo‐Arvizu Ramon A. , Aloia John F. , Dugas Lara R. , Tayo Bamidele O. , Shoham David A. , Bertino Anne‐Marie , Yeh James K. , Cooper Richard S. , Luke Amy 
Published: April 2013

ObjectivesAfrican Americans (AA) have substantially lower levels of circulating 25‐hydroxyvitamin D (25(OH)D) than whites. We compared population‐based samples of 25(OH)D in women of African descent from Nigeria and metropolitan Chicago.MethodsOne hundred women of Yoruba ethnicity from southwest Nigeria and 94 African American women from metropolitan Chicago were recruited and compared using a standardized survey protocol and the same laboratory assay for 25(OH)D.ResultsMean 25(OH)D levels were 64 nmol/l among the Nigerians and 29 nmol/l among the AA. Only 10% of the values were shared in common between the groups, and 76% of the Nigerians were above the currently defined threshold for adequate circulating 25(OH)D compared to 5% of the AA. Modest associations were seen between 25(OH)D and measures of obesity, although adjustment for these traits did not materially affect the group differences.ConclusionThese data support the presumption that skin color is an adaptive trait which has evolved in part to regulate 25(OH)D. It remains undetermined, however, whether lower values observed in AA have negative health consequences. Am. J. Hum. Biol. 25:560–562, 2013. © 2013 Wiley Periodicals, Inc.
H∞ control for discrete‐time Markovian jump systems with partial information on transition probabilities
Authors: Zhang Yan , He Yong , Wu Min , Zhang Jie 
Published: April 2013

AbstractThis paper focuses on mode‐dependent H∞ state‐feedback control for a class of discrete‐time Markovian jump systems (MJSs) with partial information on transition probabilities (TPs). The augmented free‐connection weighting matrices are introduced by considering the influence of partial information of TPs on discrete‐time MJSs and the disturbance input on the state vector. As a result, the less conservative stability criterion and bounded real lemma (BRL) of MJSs with partly unknown TPs are obtained. Then the sufficient conditions for designing the mode‐dependent H∞ controllers are derived in terms of linear matrix inequalities (LMIs). Numerical examples are given to illustrate the effectiveness and the merits of the proposed method.
Hygrothermische Gebäudesimulation mit Multizonen‐Gebäudedurchströmungsmodell
Authors: Pazold Matthias , Antretter Florian 
Published: April 2013

AbstractMit hygrothermischer Gebäudesimulation lässt sich der Feuchte‐ und Wärmetransport in einem Gebäude und über dessen Bauteile detailliert berechnen. Der natürliche oder mechanisch angetriebene Luftwechsel mit dem Außenklima sowie der Luftwechsel zwischen definierten Zonen innerhalb des Gebäudes tragen erheblich zu einem energetisch sinnvollen und behaglichen Raumklima bei. Es ist bei der Erstellung des Gebäudemodells möglich, den Luftwechsel je Zeitschritt vorzugeben. Jedoch ist dieser in Realität vom vorherrschenden Raumklima abhängig. Wird die hygrothermische Gebäudesimulation mit einem Mehrzonen‐Gebäudedurchströmungsmodell gekoppelt, so werden das Innenklima und der Luftwechsel je Zeitschritt, gegenseitig beeinflussend, simuliert. Dieser Beitrag erzielt einen Einblick in das Berechnungsverfahren des Durchströmungsmodells und dessen Kopplung mit dem hygrothermischen Gebäudemodell. Ferner ist ein Beispiel der erweiterten Simulation mit Infiltration und interzonalem Luftaustausch, auch im Vergleich zum fest definierten eingegeben Luftwechsel, enthalten.Hygrothermal building simulation coupled with multizone air flow model. With hygrothermal whole building software it is possible to calculate heat and moisture transport within a building and its components. The natural or mechanical driven air exchange between indoor and outdoor climate as well as airflow between defined building zones are significant contributors to an energetically and comfortable indoor environment. At the design of the building model it is possible to set the ventilation per time step. However, the ventilation depends on the indoor climate. The hygrothermal whole building software coupled with a multizone building airflow model can simulate the indoor climate and the natural and interzonal air exchange influencing each other. This paper gives an insight into the airflow model and its implementation and shows some results of an example simulation.