bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid cycling bipolar disorder and atypical anorexia nervosa: changes in drug metabolism
Authors: Teišerskytė J. , Norvainytė K. 
Published: August 2024

IntroductionBipolar disorder (BD) is a complex mental illness described by recurrent episodes of mania and depression. One subtype of the illness is rapid cycling BD, characterized by experiencing four or more extreme mood swings within a year. Diagnosing and treating BD can be complicated by comorbid conditions, such as atypical anorexia nervosa (AAN), marked by disordered eating and disturbing weight-related thoughts.ObjectivesTo discuss the diagnosis and treatment plan of a patient with rapid cycling BD, who experienced adverse effects from prescribed medication and later was diagnosed with comorbid AAN.Methods
We present a case of a 21 year-old man initially presenting with anxiety, low mood, and obsessive weight-related thoughts, ultimately diagnosed with major depression and mixed anxiety disorder.Results21 year-old man was diagnosed with major depression and mixed anxiety disorder, initially treated with mirtazapine and fluoxetine (limited success), later attempting escitalopram and bupropion combination (partial remission). After 2 years the patient discontinued the treatment due to feeling “euphoric”, subsequently experiencing depression and manic episodes – the initial diagnosis was rapid cycling BD. The treatment was changed to sodium valproate (up to 1500 mg/day) and aripiprazole (up to 10 mg/day), however extremely rare adverse medication effects (nosebleeds, diarrhea with blood admixture, “high-frequency sounds”) were reported. Throughout valproate treatment, the patient experienced persistent diarrhea. During hospitalization for treatment adjustment lithium carbonate was introduced at a starting dose of 900 mg/day, maintaining blood lithium levels between 0.4 mmol/l and 0.49 mmol/l. Later the dose was adjusted and a therapeutic lithium blood level was reached with 1575 mg/day of lithium carbonate. Additionally, risperidone was prescribed, however, the patient experienced an uncommon adverse reaction – nasal congestion. Subsequently, amisulpride was introduced, which provoked severe anxiety and fear, resulting in medication discontinuation. During the latest outpatient visit, fluoxetine was added to the treatment due to observed depressive symptoms. Throughout the treatment, the patient episodically intermittently starved, had persistent distressing thoughts about weight and was diagnosed with AAN. While planning further treatment it was hypothesized that comorbid AAN might affect drug metabolism and the patient was referred to a specialized inpatient facility for eating disorder management.ConclusionsThis case report highlights the complexity of psychiatric disorders and the importance of monitoring and adjusting treatment based on patient response and side effects. Additionally, it emphasizes comorbid conditions significance in influencing the primary disorder’s dynamics as well as the metabolism and effectiveness of psychiatric medications.Disclosure of InterestNone Declared
Touch hunger: trajectory and predictors of longing for physical contact during the COVID-19 pandemic in people with and without psychiatric disorders
Authors: Mann S. E. , Kok A. L. , Rius Ottenheim N. , Giltay E. J. , Penninx B. W. 
Published: August 2024

IntroductionLittle is known about touch hunger (longing for physical contact) during the COVID-19 pandemic, particularly for people with pre-existing mental health disorders.ObjectivesWe aim to investigate the dynamics of touch hunger in people with and without depressive, anxiety, or obsessive-compulsive disorders during the COVID-19 pandemic, and the potential predictors for touch hunger during lockdown.MethodsData were aggregated from three Dutch ongoing prospective cohorts with similar methodology for data collection. We included participants with pre-pandemic data gathered during 2006–2016, and who completed up to 9 online questionnaires between October 2020 and February 2022. We compared trajectories between subgroups with different pre-pandemic chronicity of disorders and healthy controls using linear mixed models. Sociodemographic, clinical (number and type of mental health disorders, personality traits) and COVID-19-related variables were analysed as predictors of touch hunger using multivariate linear regression analyses.ResultsWe included 1061 participants with (n = 811) and without (n = 250) mental health disorders. In all groups, touch hunger increased during lockdown (Fig. 1). Extraversion (β = 0.256, P <0.001), social distancing due to COVID-19 anxiety (β = 0.122, P = 0.001) and death of a close contact from COVID-19 (β = 0.073, P = 0.02) predicted higher touch hunger, while living with a partner (β = -0.109, P = 0.004) or with a partner and children (β = -0.147, P <0.001) were protective factors for touch hunger. Remarkably, pre-pandemic mental disorders did not predict touch hunger during lockdown.Image:ConclusionsSocial distancing measures have important psychological and emotional implications, as our study showed an increase in touch hunger during lockdown, which did not differ between people with and without mental health disorders. Extroverted individuals may benefit most from interventions aimed at addressing their need for physical contact during times of crisis.Disclosure of InterestNone Declared
Tunisian parents’ expectations and approaches regarding sex education of their children according to their age: a cross-sectional study
Authors: Rouached S. , Rouached M. , Lagha M. , Boudriga S. , Boumnijel A. , Dakhli A. , Zakhama K. , Ben Romdhane I. , Homri W. , Labbane R. 
Published: August 2024

IntroductionAdolescents often lack vital information for making wise sexual and reproductive decisions, leading to risks like abuse, unwanted pregnancies, and infections. Comprehensive, early, and age-appropriate sex education is crucial. While parents should play a significant role, many underestimate their responsibility. The perception of sex education is changing, with younger parents being more open to participating in their children’s education.ObjectivesThis study compares the approaches of Tunisian parents with adolescent and pre-adolescent children towards sex education.MethodsThis study used a cross-sectional design to collect data from Tunisian parents of children between the ages of 1 to 18 using an online survey. Two groups were recruited based on the age of their children, one group had parents of children younger than 10 years old, and the other had parents of adolescents. The survey included questions about the participants’ demographics, approach to sex education, reasons for their approach, and opinions on sex-related education in public schools. The survey was anonymous and confidential, and data were collected from January to March 2023 through various social media platforms.Results
This study surveyed 232 Tunisian parents with children between the ages of 1 and 18, divided into two groups based on the age of their children. The majority of participants were female (62.1%) and married (81.9%). The majority of participants in both groups agreed that sex education is important and indispensable, but only 54.7% of parents in the older children group responded positively to teaching sexual education as an independent subject. There was a significant difference between the two groups regarding their opinions about the appropriate age of sexual education for their children, and who they think should discuss sexual and reproductive health with young people. Most participants indicated that the human body and its development, sexual and reproductive health, prevention of sexually transmitted diseases and infections, contraception as well as puberty are the most important subjects to be addressed. Sexuality and sexual behaviors, the concepts of violence and safety, interpersonal relationships, consent, insults, harassment, and sexist cyberbullying were less frequently mentioned.ConclusionsIn conclusion, this study highlights the importance of sex education in Tunisia. Parents in both groups support it but differ on timing and integration. Barriers like communication challenges and religious beliefs exist. These insights can guide tailored sex education programs for Tunisian parents, promoting youth sexual and reproductive health.Disclosure of InterestNone Declared
Inflammatory based psychotic symptoms: when psychosis means encephalitis
Authors: Rojnic Kuzman M. 
Published: August 2024

AbstractSchizophrenia, as one of the most common disorders from the psychotic spectrum is most commonly detected in the phase of first psychosis and may pose a diagnostic challenge, as commonly comprise a heterogeneous group of schizophrenias, with distinct clinical presentations. If it detected in its prodromal phase without clearly developed psychotic symptoms, the diagnosis is even more unreliable, as the transition to full blown psychosis in the next two years happens in 15-40% of more, depending probably on a variety of cumulative environmental risk factors (including childhood trauma, the use of high-potency cannabis, urbanicity, season of birth). Moreover, the first episode psychosis may underlie for example the first manic episode, brief intermittent psychotic symptoms in persons with borderline personality disorders, acute reaction to trauma, the use of cannabis and psychostimulants and different organics causes, such as endocrinologic disorders and autoimmune encephalitis. Therefore, in everyday clinical practice, the diagnosis of first episode psychosis always requires an assessment of possible causes of psychosis, and also factors that may influence prognosis and treatment. Usual assessment include detailed anamnestic and heteroanamnestic data, physical examination, standard blood laboratory findings, drugs in urine/ blood, EEG and CT/MR scan. The absence of typical risk factors for schizophrenia, as well as the absence of premorbid symptoms and developmental course typical for schizophrenia, abrupt course of psychotic symptoms, symptoms such as disorientation, catatonia, speech disturbances, alteration of consciousness, neurologic signs, autonomic dysfunction and laboratory aberrations may be especially indicative for organic cause and possibly encephalitis and require further confirmation with the analysis of cerebrospinal liquor with antineuronal antibodies.Disclosure of InterestNone Declared
Peer Support in Psychosis Care: A Valuable Resource for Recovery
Authors: Cunha F. , Santos I. , Castro N. , Andrade R. , Almeida E. , Abreu J. , Martins J. , Vaz R. , Borges S. 
Published: August 2024

IntroductionA variety of peer support workers have been integrated in the mental health workforce in several countries. The effectiveness of this approach is still inconclusive. However, some data reveals promising results. Some projects have integrated peer support intervention in the treatment of psychosis. In fact, UK clinical guidelines for psychosis advise the inclusion of peer support within Early Intervention in Psychosis services.ObjectivesThe current study aims to evaluate how peer support may assist the intervention in psychosis and highlight challenges ahead in this field.MethodsNarrative review of the available scientific literature.Results
Research suggests that consistent and frequent peer support enhances social support and boosts self-confidence and the overall quality of life for people going through psychosis. Individuals diagnosed with severe mental illnesses who receive peer support reportedly experience an increased sense of control, hopefulness, and empowerment, enabling them to initiate positive changes in their lives. People going through psychosis experience internalized stigma. Destigmatization of psychotic experiences is a central theme of intervention in psychosis. Participants viewed peer support as a valuable form of assistance that could offer advantages to both peers (service users) and peer support workers.ConclusionsPeer support makes a strong contribution to destigmatising psychosis. The available date is promising and supports the effectiveness of peer support in such instances. As projects of peer support in psychosis continue to be implemented, further research should provide additional insight into the effectiveness and inherent challenges of this type of intervention.Disclosure of InterestNone Declared
The role of long-acting antipsychotics in illness relapse: an observational study
Authors: Berardelli I. , Mancinelli I. , Rogante E. , Erbuto D. , Trocchia M. A. , Longhini L. , Rapisarda L. , Bruzzese A. , Sarubbi S. , Pompili M. 
Published: August 2024

IntroductionIn patients affected by Schizophrenia and Bipolar Disorder disorders the use of antipsychotic drugs is essential in preventing the exacerbation of symptoms. The use of long-acting injectable (LAI) antipsychotics is considered an important treatment option. The aim of this study was to evaluate the incidence and predictors of relapse during antipsychotic treatment with LAIs in a sample of psychiatric outpatients up to a year after the start of long-acting therapy.ObjectivesThe study included 103 adult patients admitted to the psychiatric unit of Sant’Andrea University Hospital in Rome.MethodsWe evaluated duration of untreated illness, previous treatments, substance abuse, suicidal status, LAI dose, and use of other medicines for association with new episodes of illness or of symptomatic worsening as well as hospitalization, using bivariate and multivariate analyses.Results
Seventy-three patients were diagnosed with schizophrenia spectrum and 30 with bipolar disorders. Age at study entry averaged 36.7 years (SD= 11.55). 40.8% of patients were women. The mean age at onset were 23.11 (SD= 7.0). All the other information were reported in Table 1. On 103 patients undergoing with LAI treatment for a year only 9 (8.7%) patients had a relapse during the study period. The two groups differed according to the presence of hospitalization during the 12 months before the LAI treatment (p = .022), in particular patients with relapse were more hospitalized than patients with no relapse (62.5% vs. 21.7%). Moreover, group with relapse were more at risk of suicide during the 12 months before the LAI treatment than the other group, for both suicidal ideation (11.1% vs. 4.3%; p= .015) and attempt (25.0% vs. 3.2%; p= .049). Finally, the two groups differed according to the side effects reported during the year of LAI treatment (χ² =38.48; p< .001). Specifically, patients’ group with relapse reported more side effects caused by parkinsonism (25.0% vs. 1.1%) and tremor (25.0% vs. 0%). No differences were found for the other variables (See table 1).Image:ConclusionsIn conclusion, our observations confirm the importance of LAI therapy in real word. However, our results indicate that these drugs might not prevent subsequent exacerbations for a proportion of individuals whose illness is stabilised on continuous antipsychotic treatment. Extra pyramidal symptoms in particular might have pathophysiological implications for relapse.Disclosure of InterestNone Declared
Insomnia and Its Association with Successful Aging in the Older Indian Population: A Large Population-Based Study Based on LASI, Wave 1
Authors: Leng S. , Jin Y. , Tang X. 
Published: August 2024

IntroductionEvidence regarding the link between insomnia and successful aging (SA) in the older generation remains scarce.ObjectivesThe purpose of this study is to explore the relationship of insomnia with SA within a substantial sample of the community-dwelling Indian population.MethodsData were drawn from the Longitudinal Ageing Study in India (LASI), Wave 1, conducted during 2017-2018. Older participants aged 60 years and above who completed both the insomnia and SA surveys were included. Insomnia was determined by the presence of at least one of three symptoms: 1) difficulty in initiating sleep; 2) difficulty in maintaining sleep; or 3) early morning awakening, occurring 5 or more times per week. SA was assessed by five components: 1) absence of chronic diseases; 2) low probability of disability; 3) high cognitive functionality; 4) low probability of depression; and 5) active social engagement. The association between insomnia and SA was examined through survey-weighted multivariable logistic regression, with adjustments made for potential covariates. Subgroup analyses were carried out to evaluate interactions with age, sex, alcohol use, and smoking status.Results
A total of 31362 participants met the eligibility criteria. The overall weighted prevalence was 9.91% for insomnia and 23.94% for SA. In fully adjusted models, insomnia exhibited a negative association with SA (OR 0.70; 95% CI 0.63-0.78, see Table 1) and with each of SA’s components, except for the absence of chronic diseases (OR 0.94; 95% CI 0.85-1.04, see Table 1). Subgroup analyses, stratified by age, sex, alcohol use, or smoking status, did not reveal any significant interactions between insomnia and SA (p for interaction = 0.098, 0.873, 0.704, 0.095, respectively).Table 1.Relationship between insomnia and successful aging.InsomniaORs (95% CIs)Unadjusted modelModel 1Model 2NoReferenceReferenceReferenceYesSuccessful aging0.50 (0.45, 0.55)0.54 (0.49, 0.60)0.70 (0.63, 0.78)Absence of chronic diseases0.66 (0.61, 0.71)0.65 (0.60, 0.70)0.94 (0.85, 1.04) †Low probability of disability0.43 (0.40, 0.46)0.45 (0.42, 0.49)0.51 (0.47, 0.55)High cognitive functionality0.66 (0.61, 0.72)0.75 (0.68, 0.83)0.78 (0.71, 0.87)Low probability of depression0.33 (0.30, 0.36)0.34 (0.31, 0.38)0.38 (0.34, 0.42)Active social engagement0.79 (0.73, 0.86)0.87 (0.80, 0.95)0.86 (0.78, 0.94)† p > 0.05; ORs, odds ratios; 95% CIs, 95% Confidence intervals.Model 1 adjusted for: age, sex, level of education, work status, marital status, place of residence, economic status, caste; Model 2 adjusted for: model 1 plus body mass index (BMI), alcohol use, smoking status.ConclusionsInsomnia was negatively linked with SA within the older Indian population. Future prospective studies are warranted to validate these relationships, investigate underlying mechanisms, and enhance the understanding and promotion of SA.Disclosure of InterestNone Declared
Women’s addiction : experiences at Arrazi Psychiatric Hospital in Morocco
Authors: Khallouk A. 
Published: August 2024

IntroductionDrug addiction, also called substance use disorder, is a disease that affects a person’s brain and behavior and leads to an inability to control the use of a legal or illegal drug or medicine. there is a complex interplay of neurobiology, genetics, and the environment --nature and nurture-- that play into the development of addiction, alcohol, and other drug use disorder.Substances such as alcohol, marijuana and nicotine also are considered drugs.Research has shown that women often use drugs differently, respond to drugs differently, andcan have unique obstacles to effective treatment as simple as not being able to find child care orbeing prescribed treatment that has not been adequately tested on women.Objectivesdescribe the socio-demographic and clinical characteristics of female patients admitted to the addictology department of Arrazi Hospital in SaléMethodsRetrospective study with descriptive and analytical aims on the files of women who were admitted to the addictology service since its opening in 2000, with the aim of specifying the prevalence and the characteristics of addictive behaviors in the female population.Resultsin progressConclusionsin progressDisclosure of InterestNone Declared
The Relationship Between Problematic Internet Use (PIU) and Psychological Distress: A cross- sectional study
Authors: Theodoratou M. , Varvitsioti M. , Kougioumtzis G. A. , Tsitsas G. , Kaltsouda A. , Flora K. , Papathanasiou C. 
Published: August 2024

Introduction
Problematic Internet Use (PIU) has emerged as a widespread social challenge and is characterised by an individual’s inability to regulate their internet use, culminating in a negative impact on their daily life. It is vital to explore the possible mediating relationship between psychological distress and unregulated Internet use.ObjectivesThe study aims to explore the relationship between problematic Internet use, psychological distress and quality of life.MethodsIn this cross-sectional study, participants engaged in a structured data collection process using Google Forms, responding to a series of questions developed through a quantitative methodology using a Likert scale questionnaire.The K-6 Distress Scale and the World Health Organisation Quality of Life (WHOQOL) were used in conjunction with questions about demographics and problematic internet use.The integration of these multiple measures aimed to provide comprehensive insights into the effects and patterns of Internet use and its association with different levels of distress and demographic variables.Results
Statistical data analysis revealed notable associations between psychological distress and several variables, including age, education, employment status and health, but no significant associations were found with place of residence or marital status. Significant associations were also found between problematic Internet use (PIU) and variables such as age, education, employment, marital status and health. However, no significant association was found with place of residence. Quality of life was also found to be correlated with age, employment status and health, but not with marital status or educational attainment. In addition, the analysis revealed a strong association between problematic internet use (PIU) and psychological distress. A concurrent increase in reported psychological distress was observed as PIU levels escalated, reinforcing the relationship between excessive internet use and psychological wellbeing. This suggests that PIU may be associated with increased levels of mental distress in the population studied.ConclusionsIn conclusion, this study provides valuable insights into the multifaceted dynamics of mental distress, PIU, and quality of life in relation to demographic factors. It underscores the importance of holistic approaches to mental health that consider individual characteristics and behaviors, with a particular focus on addressing the challenges posed by problematic internet use. Further research and tailored interventions are needed to better understand and support people facing these complex issues.Disclosure of InterestNone Declared
Prevalence, sociodemographic factors and psychological distress related to compulsive buying online
Authors: Mnif M. , Guermazi F. , Mnif D. , Abid W. , Feki I. , Baati I. , Masmoudi J. 
Published: August 2024

IntroductionSince that the online commerce provides an important shopping environment, it has been argued that traditional buying-shopping disorder may migrate into the online market.ObjectivesThe aims of the current study were to investigate the prevalence of online buying-shopping disorder, and to determine sociodemographic and psychological factors related to this addictive behavior.MethodsA cross-sectional, descriptive and analytical study was conducted among subjects who had already made at least one online shopping. Data was collected using a self-questionnaire published by GOOGLE FORMS. Assessment included the short version of the Internet Addiction Test modified for online shopping sites (s-IATshop). The Hospital Anxiety and Depression Scale (HADS) has been used to assess anxiety and depression.Results
A total of 137 participants aged 34.62 ± 9.82 years completed the online questionnaire.Only 4 (2.9%) participants had a probable compulsive buying shopping on line.The HADS-A score ranged from 0 to 14, with a mean of 6.85 +/- 3.49 and almost half of the participants (44.5%; N=61) had anxiety symptoms.
A high s-IAT shopping score was correlated with secondary or university education (p=0.046). We also found that women, who were younger and had higher incomes, had the highest scores on the s-IAT-shopping scale, without however confirming statistical significance.ConclusionsOur study has shown the potential vulnerability factors for compulsive online shopping disorder. Thus, this behaviour deserves to be taken into account in behavioural addictions.Disclosure of InterestNone Declared