bluuebunny/crossref_metadata_2025_split huggingface dataset:
Family educational patterns in strengthening teenager's character generation z: a literature review
Authors: Keraf Fransiskus Markus Pereto , Falo Marsianus , Matoneng Ody Wolfrit , Kollo Fredik Lambertus , Nurlailah N. 
Published: July 2024

Generation Z teenagers were born in the internet and technological automation era. The negative impact of technological developments causes violations of applicable norms. Teenagers who are involved in juvenile delinquency are caused by a lack of assistance and family control. This study aims to identify appropriate educational patterns for integrating positive moral habits and norms in the family. The writing method uses a literature review. The data collection process through a literature review is supported by a comprehensive analysis of publications from academic journals in the last 5 (five) years, focusing on educational patterns in the family to strengthen the character of Generation Z teenagers. The study results show that there are 3 (three) patterns of education in the family to develop the character of Generation Z teenagers. The three education patterns are family education patterns based on example, monitoring, and understanding psychology. Parents must integrate these three educational patterns in the family to create a golden generation with positive, quality characters. Character development formed through family educational patterns can be collaborated with other character education models, such as in the school or community environment. AbstrakRemaja generasi Z lahir di era internet serta otomatisasi teknologi. Dampak negatif perkembangan teknologi menyebabkan terjadinya pelangaran norma yang berlaku. Remaja yang terlibat kenakalan remaja disebabkan kurangnya pendampingan serta kontrol keluarga. Kajian ini bertujuan mengidentifikasi pola pendidikan yang tepat dalam mengintegrasikan pembiasaan moral dan norma yang positif dalam keluarga. Adapun metode penulisan menggunakan kajian pustaka. Proses pengumpulan data melalui tinjauan literatur ini didukung oleh analisis publikasi yang komprehensif dari jurnal akademik pada 5 (lima) tahun terakhir, berfokus pada pola pendidikan dalam keluarga untuk menguatkan karakter remaja generasi z. Hasil kajian menunjukan bahwa terdapat 3 (tiga) pola pendidikan dalam keluarga untuk mengembangkan karakter remaja generasi z. Ketiga pola pendidikan tersebut yakni pola pendidikan keluarga melalui keteladanan, pemantauan dan pemahaman psikologi. Orangtua harus mampu mengintegrasikan ketiga pola pendidikan dalam keluarga tersebut untuk mewujudkan generasi emas yang memiliki karakter positif berkualitas. Pengembangan karakter yang dibentuk melalui pola pendidikan dalam keluarga dapat dikolaborasikan dengan model pendidikan karakter lainnya, seperti di lingkungan sekolah maupun masyarakat.Kata Kunci: generasi z; karakter remaja; pendidikan keluarga
Micro-curriculum design of educational technology product-oriented in entrepreneurship courses
Authors: Emilzoli Mario , Priandani Ai Pemi 
Published: July 2024

Most universities in Indonesia have organized entrepreneurship courses through study programs according to their respective characteristics. However, many entrepreneurial product outputs from these courses remain irrelevant to the field of expertise in the study program, including the Educational Technology study program. A course's output or achievement can be conditioned through the curriculum or the context of the course, known as the micro curriculum. Based on this, this study aims to produce a micro curriculum design for entrepreneurship courses oriented towards educational technology products. The method used is Design-Based Research (DBR), which involves needs analysis, curriculum design, construction, evaluation, and reflection. The results showed that the curriculum design developed met the needs of entrepreneurial competencies relevant to the educational technology industry. In addition, this study also provides recommendations related to learning content, learning strategies, and assessment models that can be used to support the effectiveness of the designed curriculum. Hopefully, this curriculum can help students understand entrepreneurial theory and apply it to make innovative educational technology products. AbstrakMayorititas perguruan tinggi di seluruh Indonesia pada dasarnya telah menyelenggarakan mata kuliah kewirausahaan melalui program studi sesuai dengan ciri khas masing-masing. Namun, masih banyak ditemui luaran produk kewirausahaan dari mata kuliah tersebut tidak relevan dengan bidang keahlian yang terdapat pada program studi, tidak terkecuali pada program studi Teknologi Pendidikan. Luaran atau capaian dari sebuah mata kuliah pada dasarnya dapat dikondisikan melalui kurikulum atau dalam konteks mata kuliah dikenal dengan kurikulum mikro. Berdasarkan hal tersebut, penelitian ini bertujuan untuk menghasilkan desain kurikulum mikro mata kuliah kewirausahaan yang berorientasi pada produk teknologi pendidikan. Metode yang digunakan adalah Design Based Research (DBR), yang melibatkan analisis kebutuhan, desain dan konstruksi kurikulum, serta evaluasi dan refleksi. Hasil penelitian menunjukkan bahwa desain kurikulum yang dikembangkan mampu memenuhi kebutuhan kompetensi kewirausahaan yang relevan dengan industri teknologi pendidikan. Selain itu, penelitian ini juga memberikan rekomendasi terkait konten pembelajaran, strategi pembelajaran, dan model penilaian yang dapat digunakan untuk mendukung efektivitas kurikulum yang dirancang. Diharapkan, kurikulum ini dapat membantu mahasiswa tidak hanya memahami teori kewirausahaan, tetapi juga menerapkannya dalam pembuatan produk teknologi pendidikan yang inovatif.Kata Kunci: kewirausahaan; mikro kurikulum; teknologi pendidikan
Radioscapholunate Arthrodesis for Management of Madelung Deformity
Authors: Barrientos Alberto , Margalit Adam , Ayalon Omri 
Published: July 2024

Case:
A 32-year-old woman with bilateral Madelung deformity presented with severe pain and arthritis of the radiocarpal and distal radioulnar joints. At final follow-up, 17 months for the left and 12 months for the right wrist, she had excellent functional results with no pain. Range of motion was 30° of flexion and 30° of extension with full pronosupination.

Conclusion:
There is paucity in the literature regarding salvage procedures in adults with this deformity. We demonstrate treatment with distal ulna excision and an radioscapholunate arthrodesis. This procedure may be indicated in Madelung deformity and proximal radiocarpal and distal radioulnar joint arthritis.
TKR in Hemophilic Arthropathy: A Combination of Special Surgical Considerations and Novel Nonacog Beta Pegol
Authors: Chhetri Prakrit , Sood Chetan , Shakya Amir Ratna , Jung Khatri Kishor 
Published: July 2024

Case:
A 29-year-old man with hemophilia B presented with advanced arthropathy of the right knee, resulting in poor knee functional scores and difficulties in his livelihood. The patient underwent total knee replacement while receiving nonacog beta pegol factor IX by a multidisciplinary approach.

Conclusion:
Hemophilias commonly result in end-stage hemophilic arthropathy of the joints at a young age that may warrant joint replacement surgeries. This case report illustrates the surgical protocol of total knee arthroplasty in a patient who received a long-acting factor IX preparation.
Local and systemic biodistribution of a small molecule radiopharmaceutical probe after transcatheter embolization and intra-arterial delivery in a porcine orthotopic renal tumor model
Authors: Rice Samuel L. , Muñoz Fernando Gómez , Benjamin Jamaal L. , Alnablsi Mhd Wisam , Quadri Rehan , Osborne Joseph R. , Beets-Tan Regina 
Published: July 2024

Abstract

Background
Small molecule biomacromolecules target tumor specific antigens. They are employed as theranostic agents for imaging and treatment. Intravenous small molecule radioligands exhibit rapid tumor uptake and excretion.
However, systemically administration for peptide receptor radionuclide therapy brachytherapy lacks the therapeutic index to completely treat solid tumors beyond palliation. We study intra-arterial delivery with tumor embolization of a small molecule as a means to deliver local intertumoral brachytherapy for curative internal ablation.
Results
¹⁸F-Fluorodeoxyglucose (FDG) was used as a surrogate for a small molecule theranostic agent in a porcine renal tumor model, this tumor model is not known to specifically express human tumor antigens, but the model demonstrates similar vascularity. Angiography and micron particle embolization of the tumor arterioles was performed in a renal tumor model. Significantly more, 2x to 4x more tumor uptake, for study intra-arterial. administration compared to i.v (%ID/g = 44.41 ± 2.48 vs 23.19 ± 4.65 p= 0.0342* at 1 min and 40.8 ± 2.43 vs 10.94 ± 0.42 p=0.018* 10 min). At later time points, up to 120 mins after injection, washout of the tracer from the tumor was observed, but percent injected dose per gram remained elevated, with 3x higher concentration of FDG with intra-arterial administration compared to intravenous, but the difference was not statistically significant. Trend towards diminished systemic percent injected dose per gram measured in the blood, liver, kidney, spleen, muscle, and urine for study intra-arterial compared to intravenous administration.
Conclusion
Combining intra-arterial administration of a small molecule radioprobe surrogate with embolization of the tumor's arterioles extending the time for interaction of the drug within the tumor by diminishing flow out of the tumor via the efferent capillaries significantly increases the first pass uptake of the SM drug within a tumor and decreased the radiation to normal non-tumor tissues when compared to intravenous injection of the same drug. The minimally invasive drug delivery allows tumor specific theranostic treatment of renal tumors with a brachytherapy absorbed dose of radiation that is potentially curative.
Modelling of the Structural Properties of Concrete With Rice Husk Ash (Rha) as a Biocomposite Using Osadebe Second Degree Polynomials.
Authors: Akeke Godwin A. , Udokpoh U. U. , Nnaji Charles C 
Published: July 2024

Abstract

The demand for concrete is increasing in tandem with population growth and urbanization. Cement is an important ingredient in concrete production. Cement is a major contributor to global carbon dioxide emissions during its manufacturing processes. Therefore, sustainable alternatives to normal cement are required for the production of sustainable concrete. Rice husk ash has proven intriguing properties as a sustainable alternative for producing green and eco-friendly concrete. Because the laboratory work needed to assess its properties is both time-consuming and complex, regression models can be effectively used to predict the properties of concrete containing rice husk ash. Using Osadebe's second-degree polynomial equation, a mathematical optimization model for predicting the compressive, tensile, and flexural strengths of RHA concrete was developed in this study. The developed model may be used to compute compressive, tensile, and flexural strengths based on the proportions of four constituents in a given mix. Also, a favourable comparison may be drawn between the model and experimental responses. Furthermore, the statistical analysis summary revealed that the model-predicted values were in good agreement with the experimental values. Lastly, some of the optimized mixes attain strength values that are suitable for use in structural or load-bearing concrete.
Optimizing Urban Sustainability: TheEffects of Green Infrastructure and its Application in Indian Cities
Authors: Pachouri Vikrant , Kothari Prafull 
Published: July 2024

Abstract

This research investigates the effectiveness and application of green infrastructure in urban contexts within five major Indian cities: Some of the major cities are Delhi, Mumbai, Bangalore, Chennai, and Kolkata. The research design also incorporates both qualitative and quantitative approaches including a literature review, case studies, surveys with 1000 residents, and interviews with 25 urban planning experts. The research findings show that green infrastructure has a positive impact on the environment, economy, and society. Green roofs in Delhi minimize stormwater and energy use whereas green belts and mangrove replanting in Mumbai lessen flood impacts and improve air quality. Bangalore’s rainwater harvesting has increased groundwater recharge while Chennai’s urban wetlands help in flood control and reduction in temperature. Kolkata’s community gardens not only enhance the green area of the city but also contribute to local food production. The analysis of the result is conducted and the results demonstrate the F-statistics value as 8.48 and the p-value as 9.90 x 10− 7. But there are some issues to consider including maintenance costs, funding, and public awareness. Thus, the study comes up with recommendations that green infrastructure should be supported through policies, community involvement, and integrated urban planning as crucial for sustainable urban development in India.
The Sit-Up Test to Assess Orthostatic Hypotension in Individuals with Spinal Cord Injury: Validity and Reliability
Authors: Wecht Jill Maria , Maher Matthew T , Lirshblum Steven C. , Escalon Miguel X. , Weir Joseph P 
Published: July 2024

Abstract

Due to decentralized autonomic nervous system function, individuals with spinal cord injury (SCI) are reported to have an increased prevalence of orthostatic hypotension (OH). Diagnosis of OH is made with active standing or tilt table testing, with limited the use in individuals with SCI. An alternative approach to assess OH is the sit-up test which involves passive repositioning from the supine to the seated position. The purpose of this study was to determine the reliability and validity of the sit-up test in a large, diverse group of individuals with SCI. A total of 166 participants completed two sit-up tests, 119 individuals with SCI and 47 uninjured controls and 36 individuals who completed the sit-up tests also underwent a head-up tilt test. The mean difference in change in BP from sit-up test 1 to sit-up test 2 was not significant for either SBP or DBP, and neither level nor severity of injury contributed significantly to the reliability assessments. However, the reliability assessments showed disappointing results with generally low interclass correlation coefficients (ICC) values and large standard error of measurement (SEM). Comparison of the BP responses between the sit-up test and the head up tilt showed good sensitivity and specificity, with positive predictive values of 75% for both SBP and DBP. Prevalent BP instability likely contributed to the poor reliability of the sit-up test, but the test is easy to perform with good sensitivity and specificity and a high likelihood ratio for the valid assessment of OH in individuals with SCI.
Heart and Lung Point-of-Care Ultrasonography Tutoring in Internal Medicine: a Randomized Controlled Trial
Authors: Leidi Antonio , Krauer Juliette , Soret Guillaume , Parent Thibault , Marti Christophe , Meyer Philippe , Juillerat André , Bex Stijn , Suh Noémie , Rouyer Frédéric , Siegenthaler Nils , Grosgurin Olivier 
Published: July 2024

Abstract

Background: In recent years, point-of-care ultrasonography (POCUS) has been integrated into internal medicine practice with most curricula composed of a single course. Despite competency acquisition during the course, a significant decline in proficiency occurs in the subsequent weeks due to a lack of regular practice and training. This study aims to evaluate the impact of a structured POCUS tutoring, on POCUS use and skills retention at 6 months.
Methods: In this randomized controlled trial, internal medicine residents were enrolled after completing a practical course focused on heart and lung ultrasonography. Residents assigned to the intervention group were paired with a tutor, and time slots were scheduled for bedside direct supervision over the following 6 months. The primary outcome was the proportion of residents who successfully completed at least 25 POCUS examinations six months after inclusion. Secondary outcomes included self- and blinded-expert-assessed POCUS competency skills.
Results: Between January and May 2022, 23 residents were included in the study. The intervention significantly increased the proportion of participants reaching the primary outcome (70% versus 0%; p<0.001) with a median of 27 (interquartile range, IQR, 6 to 44) supervised examinations performed versus 0 (IQR 0 to 0) in intervention and control arm respectively; p<0.001. After 6 months, proficiency was higher for most heart imaging but not for lung imaging, as assessed through self-assessment by participants or independently by blinded experts.
Conclusions: Structured POCUS supervision significantly enhances the number of POCUS examinations and proficiency at 6-months, particularly in applications requiring greater visuospatial skills.
A rare case of IgDλ/λ free Multiple Myeloma as a virtuous example of collaboration between clinical activity and laboratory medicine
Authors: Sasso Mauro , Germano Candida Rosaria , Staffella Vanda , Ceci Luigi , Tarantini Giuseppe 
Published: July 2024

Abstract

BACKGROUND: IgD Multiple Myeloma (MM) is a rare hematological neoplasm characterized by an aggressive course compared to the other isotypes of Myeloma; its laboratory findings are usually anemia, presence of Bence Jones protein (BJP), hypogammaglobulinemia, lack of a monoclonal peak on serum protein electrophoresis (SPE), renal failure, osteolytic lesions.
CLINICAL CASE: A 72-year-old man with bone pain presented to the Hematology Unit because of bone pain and laboratory tests showing a Monoclonal Component type λ and normocytic anemia (Hemoglobin level 10.5 g/dL). A conventional skeletal radiography of cranium and spine in toto was performed and showed multiple discopathies, sacroiliitis and bilateral coxarthrosis.
RESULTS: Laboratory tests performed in Clinical Pathology and Microbiology Unit showed hypogammaglobulinemia, acute renal failure (s-creatinine 2.86 mg/dL, eGFR 39,01 mL/min), s-calcium 9.3 mg/L, serum Free Light Chains ratio 0,0044, presence of BJP type λ, a peak of 19.7 g/L in SPE. Serum immunofixation (sIFE) performed by anti-IgD and λ free serum showed a monoclonal IgDλ band and a monoclonal λ free band. Nuclear Magnetic Resonance (NMR) imaging showed cervical-dorso-lumbar and pelvic osteolysis, while osteomedullary biopsy showed a 70% plasma cell infiltration. Symptomatic IgDλ MM was diagnosed: the symptomatic findings where anemia and bone disease.
CONCLUSION: The 72-year-old patient of our clinical case presented at diagnosis some features commonly present in IgD MM. In this case, the laboratory adopted new diagnostic protocols in order to make a correct diagnosis; the hematological parameters, SPE and sIFE were monitored for 56 months.
New therapies have been shown to improve outcomes in this disease and a recent revision of recommendations has contributed to good clinical practice for patients with relapsed/refractory MM.
Pro-Inflammatory Effects of Inhaled Great Salt Lake Dust Particles
Authors: Cowley Jacob M. , Deering-Rice Cassandra E. , Lamb John G. , Romero Erin G. , Almestica-Roberts Marysol , Serna Samantha N. , Sun Lili , Kelly Kerry E. , Whitaker Ross T. , Cheminant Jenna , Venosa Alessandro , Reilly Christopher A. 
Published: July 2024

Abstract

Background: Climatological shifts and human activities have decimated lakes worldwide. Water in the Great Salt Lake, Utah, USA is at near record lows which has increased risks for exposure to windblown dust from dried lakebed sediments. Formal studies evaluating the health effects of inhaled Great Salt Lake dust (GSLD) have not been performed despite the belief that the dust is harmful. The objectives of this study were to illustrate windblown dust events, assess the impact of inhaled dust on the lungs, and to identify mechanisms that could contribute to the effects of GSLD in the lungs.
Results: An animation, hourly particle and meteorological data, and images illustrate the impact of dust events on the Salt Lake Valley/Wasatch front airshed. Great Salt Lake sediment and PM2.5 contained metals, lipopolysaccharides, natural and anthropogenic chemicals, and bacteria. Inhalation and oropharyngeal delivery of PM2.5 triggered neutrophilia and the expression of mRNA for Il6, Cxcl1, Cxcl2, and Muc5ac in mouse lungs, was more potent than coal fly ash (CFA) PM2.5, and more cytotoxic to human airway epithelial cells (HBEC3-KT) in vitro. Induction of IL6 and IL8 was replicated in vitro using HBEC3-KT and THP-1 cells. For HBEC3-KT cells, IL6 induction was variably attenuated by EGTA/ruthenium red, the TLR4 inhibitor TAK-242, and deferoxamine, while IL8 was attenuated by EGTA/ruthenium red. Inhibition of mRNA induction by EGTA/ruthenium red suggested roles for transition metals, calcium, and calcium channels as mediators of the responses. Like CFA, GSLD and a similar dust from the Salton Sea in California, activated human TRPA1, M8, and V1. However, only inhibition of TRPV1, TRPV3, and a combination of both channels impacted cytokine mRNA induction in HBEC3-KT cells. Responses of THP1 cells were partially mediated by TLR4 as opposed to TRP channels and mice expressing a “humanized” form of TRPV1 exhibited greater neutrophilia when exposed to GSLD via inhalation.
Conclusions: This study suggests that windblown dust from Great Salt Lake and similar lake sediments could pose a risk to humans via mechanisms including the activation of TRPV1/V3, TLR4, and possibly oxidative stress.
An Interactive Course Program on Nutrition for Medical Students: Interdisciplinary Development and Mixed-Methods Evaluation
Authors: Ngoumou Gonza , Koppold Daniela A. , Wenzel Laetitia , Schirmaier Anne , Breinlinger Carolin , Pörtner Lisa M. , Jordan Stefan , Schiele Julia K. , Hanslian Etienne , Koppold Annika , Stock-Schröer Beate , Varvarezou Dimitra M. , Jeitler Michael , Ortiz Miriam , Michalsen Andreas , Stritter Wiebke , Seifert Georg , Kessler Christian S. 
Published: July 2024

Abstract

Nutrition plays a crucial role in human and planetary health, as prevailing nutritional patterns significantly contribute to the global non-communicable disease pandemic. Moreover, the global food system is inextricably linked to planetary health deterioration. The relevance of nutrition for individual and planetary health is insufficiently addressed in German medical schools. Here, we present a two-week course for medical students in the 8th semester at Charité - Universitaetsmedizin Berlin on nutrition and fasting in the context of human and planetary health. The course was developed iteratively along the Kern cycle for medical curricula and underwent evaluation through a mixed-methods design spanning across two consecutive semesters. Assessment involved quantitative questionnaires and qualitative interviews. The main exploratory outcome was the overall module rating. Further outcomes encompassed in-depth evaluations of specific aspects, including content, teaching methods, instructor performance, and subjective experiential aspects. The conceptualisation resulted in a highly participative two-week course of 37.5 hours. The main learning objectives aimed at the acquisition of competences and competencies in four areas: (1) the role of nutrition in health and disease; (2) the exploration of global food systems; (3) communication on subjects of nutrition; (4) culinary medicine. Various interactive didactic methodologies were used. The majority of the participants (n = 27) gave high ratings to the course (48.2% “very good”, 29.6% “good”). The conviction that nutrition influences health and disease increased over the course (41.2% before versus 74.1% after the course). In the qualitative interviews (n = 8) the course content, its didactical diversity and the positive group experience were appreciated. Our results indicate that it could be worthwhile to further incorporate nutrition curricula in medical education.