bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of serum muscular creatinine phosphokinase levels in patients with adenomyosis as a non‐invasive diagnostic marker
Authors: Bulut Aydemir Hilal Mürüvvet , Kahyaoğlu Serkan , Halilzade İnci , Moraloğlu‐Tekin Özlem 
Published: July 2024

AbstractObjectiveIn the present study, we aimed to compare serum CK‐MM levels in patients with and without adenomyosis and to investigate whether CK‐MM level can be a non‐invasive marker for myometrial damage due to adenomyosis.Materials and MethodsOur study was a prospective case‐control study in a tertiary center and consisted of 40 patients with a clinical/ultrasonographic diagnosis of adenomyosis and 40 patients without a clinical/ultrasonographic diagnosis of adenomyosis as the control group based on recently published morphological uterus sonographic assessment (MUSA) criteria. Individuals of similar age who signed a voluntary consent form were included in our study. Demographic, clinical, and laboratory findings of the patients in both groups were recorded. Blood serum samples were used for the determination of serum CK‐MM levels of the participants in our study. The samples were analyzed by using the human CK‐MM enzyme‐linked immunosorbent assay (ELISA) kit.ResultsIn our study, the mean serum CK‐MM level was 16.2 ± 21.7 (ng/dL) in patients with adenomyosis and 2.6 ± 2.2 (ng/dL) in patients without adenomyosis. Serum CK‐MM level was statistically significantly higher in the patient group with adenomyosis than in the control group (p < 0.001). The CK‐MM threshold value of 3.43 ng/mL, with a sensitivity of 82.5% and specificity of 85%, has been found to be a valuable distinguishing level in patients with and without adenomyosis.ConclusionIn this study, we demonstrated that serum CK‐MM can be used as a non‐invasive diagnostic method in patients with adenomyosis. As the number of studies around this subject in the literature is insufficient, larger studies are needed to use CK‐MM as a diagnostic marker in adenomyosis.
Comparing letters written by humans and ChatGPT: A preliminary study
Authors: Matsubara Shigeki 
Published: July 2024

AbstractObjectiveThere are no criteria for what type of manuscript and to what extent ChatGPT use is permissible in writing manuscripts. I aimed to determine which, human or ChatGPT, writes more readable letters to the editor and whether ChatGPT writes letters mimicking a certain person. I aimed to provide hints as to what makes the difference between humans and ChatGPT.MethodsThis is a descriptive pilot study. I tasked ChatGPT (version 3.5) with generating a disagreement letter to my previous article (Letter 0). I wrote a letter involving three weaknesses of the addressed article (Letter 1). I provided ChatGPT with these three weaknesses and tasked it with generating a letter (Letter 2). Then, I supplied my authored letters and tasked ChatGPT with emulating my writing style (Letter 3). Eight professors evaluated the letters' readability and ChatGPT assessed which letter was more likely to be accepted.ResultsChatGPT produced coherent letters (Letters 0 and 2). Professors rated the readability of Letters 1 and 2 similarly, finding Letter 3 less readable. ChatGPT determined that the human‐authored Letter 1 had a slightly higher acceptance likelihood than the ChatGPT‐generated Letter 2. Although ChatGPT identified personal writing styles, its mimicry did not enhance the letter's quality.ConclusionThis preliminary experiment indicates that human‐written letters are perceived to be as readable as, or no less readable than, ChatGPT‐generated ones. It suggests that human touch, with its inherent enthusiasm, is essential for effective letter writing. Further comprehensive investigations are warranted to ascertain the extent to which ChatGPT can be used in this domain.
Composite electrolyte with self‐inserted structure and all‐trans F conformation provides fast Li+ transport for solid‐state Li metal batteries
Authors: Liang Ziyang , Liu Chang , Bai Xiang , Zhang Jiahui , Chang Xinyue , Guan Lixiang , Lu Tiantian , Du Huayun , Wei Yinghui , Wang Qian , Wei Tao , Liu Wen , Zhou Henghui 
Published: July 2024

AbstractSolid‐state Li metal battery has attracted increasing interests for its potentially high energy density and excellent safety assurance, which is a promising candidate for next generation battery system. However, the low ionic conductivity and Li+ transport number of solid‐state polymer electrolytes limit their practical application. Herein, a composite polymer electrolyte with self‐inserted structure is proposed using the layered double hydroxides (LDHs) as dopant to achieve a fast Li+ transport channel in poly(vinylidene‐co‐trifluoroethylene) [P(VDF‐TrFE)] based polymer electrolyte. In such a composite electrolyte, P(VDF‐TrFE) polymer has an all‐trans conformation, in which all fluorine atoms locate on one side of the polymer chain, providing fast Li+ transport highways. Meanwhile, the LDH can immobilize the anions of Li salts based on the electrostatic interactions, promoting the dissociation of Li salts, thereby enhancing the ionic conductivity (6.4 × 10−4 S cm−1) and Li+ transference number (0.76). The anion immobilization effect can realize uniform electric field distribution at the anode surface and suppress the dendritic Li growth. Moreover, the hydrogen bonding interaction between LDH and polymer chains also endows the composite electrolyte with strong mechanical properties. Thus, at room temperature, the Li || Li symmetric cells can be stably cycled over 1000 h at a current density of 0.2 mA cm−2, and the full cells with LiFePO4 cathode deliver a high capacity retention (>95%) after 200 cycles. This work offers a promising route to construct solid‐state polymer electrolytes with fast Li+ transport.image
Mapping collective consciousness to consumer research: In‐person to virtual social presence
Authors: Lee Hyunjung Crystal , Broniarczyk Susan M. , Zheng Jianqing (Frank) 
Published: July 2024

AbstractShteynberg's (Journal of Consumer Psychology, 2024) work on collective consciousness offers unique and meaningful insights into consumer behavior by emphasizing a “we‐representation” that is comprised not of a self‐aware “I” and an external “you” but rather complete immersion as a unified “we”. In this commentary, we situate collective consciousness within existing social presence research in consumer behavior and discuss its potential to expand the scope of social presence research. Specifically, we utilize a social presence framework that highlights the type of co‐presence (in‐person vs. virtual) and the extent of interactivity (interactive vs. passive) discussing the psychological mechanisms and linkage to collective consciousness. In addition to discussing shared consumption and shared decision‐making, we assess the implications of collective consciousness for consumer contexts facilitated by virtual technologies: fake news, live streaming, virtual reality, cryptocurrencies, and crowdfunding. We conclude by highlighting future avenues for integrating collective consciousness into consumer psychology research.
Occult femoral fracture: Be aware of dual energy computed tomography
Authors: Ruggiero Sergio , Bellini Davide , Rengo Marco , Vicini Simone , Carbone Iacopo 
Published: July 2024

AbstractA 74‐year‐old man was admitted to our emergency department following minor trauma. Plain radiographs and standard computed tomography (CT) scans revealed no signs of fractures. Subsequently, virtual noncalcium (VNCa) images were reconstructed, showing a linear area of bone marrow edema (BME) resembling a femoral neck fracture. Magnetic resonance imaging (MRI) was performed to confirm the presence of BME and an associated intraspongious fracture. In an emergency setting, dual‐energy CT (DECT) and VNCa images can successfully identify occult femoral fractures, especially in patients with mild symptoms and minor trauma, thereby preventing misdiagnosis.
Enterovirus A71 2A‐S125A acts as an attenuated vaccine candidate, indicating a universal approach in developing enterovirus vaccines
Authors: Zhang Peng , Zou Wenjia , Xiong Rui , Wu Yong , Fan Changfa , Peng Yihong 
Published: July 2024

AbstractEnteroviruses are important human pathogens with diverse serotypes, posing a major challenge to develop vaccines for individual serotypes, the success of polio vaccines in controlling and eradicating polio, along with the recent emergence and high prevalence of enterovirus‐caused infectious diseases, highlights the importance of enterovirus vaccine development. Given our previous report on enteroviruses weakened by the 2 A S/T125A mutation, we assessed the potential of the EV‐A71 2A‐125A mutant as a vaccine candidate to address this challenge. We found that the 2A‐125A mutant caused transient mild symptoms, low viral loads, and no significant pathological changes mild pathological changes in hSCARB2‐KI mice, producing long‐lasting cross‐neutralizing antibodies against two EV‐A71 wild strains. Pre‐exposure to the 2A‐125A mutant substantially protected against the EV‐A71 Isehara wild‐type strain, causing minor pathologies, significantly reducing muscle and lung inflammation, and preventing neurological damage, with reduced viral loads in vivo. Pre‐exposure also distinctly suppressed the expression of pro‐inflammatory cytokines, correlating to the severity of clinical symptoms. Collectively, the EV‐A71 2A‐125A mutant was attenuated and could generate a robust and protective immune response, suggesting its potential as a vaccine candidate and global solution for specific enterovirus vaccine development.
Increased interleukin‐6 levels are associated with atrioventricular conduction delay in severe COVID‐19 patients
Authors: Accioli Riccardo , Lazzerini Pietro Enea , Salvini Viola , Cartocci Alessandra , Verrengia Decoroso , Marzotti Tommaso , Salvadori Fabio , Bisogno Stefania , Cevenini Gabriele , Voglino Michele , Gallo Severino , Pacini Sabrina , Pazzaglia Martina , Tansini Angelica , Otranto Ambra , Laghi‐Pasini Franco , Acampa Maurizio , Boutjdir Mohamed , Capecchi Pier Leopoldo 
Published: July 2024

AbstractBackgroundSeverely ill patients with coronavirus disease 2019 (COVID‐19) show an increased risk of new‐onset atrioventricular blocks (AVBs), associated with high rates of short‐term mortality. Recent data suggest that the uncontrolled inflammatory activation observed in these patients, specifically interleukin (IL)‐6 elevation, may play an important pathogenic role by directly affecting cardiac electrophysiology. The aim of our study was to assess the acute impact of IL‐6 changes on electrocardiographic indices of atrioventricular conduction in severe COVID‐19.MethodsWe investigated (1) the behavior of PR‐interval and PR‐segment in patients with severe COVID‐19 during active phase and recovery, and (2) their association with circulating IL‐6 levels over time.ResultsDuring active disease, COVID‐19 patients showed a significant increase of PR‐interval and PR‐segment. Such atrioventricular delay was transient as these parameters rapidly normalized during recovery. PR‐indices significantly correlated with circulating IL‐6 levels over time. All these changes and correlations persisted also in the absence of laboratory signs of cardiac strain/injury or concomitant treatment with PR‐prolonging drugs, repurposed or not.ConclusionsOur study provides evidence that in patients with severe COVID‐19 and high‐grade systemic inflammation, IL‐6 elevation is associated with a significant delay of atrioventricular conduction, independent of concomitant confounding factors. While transient, such alterations may enhance the risk of severe AVB and associated short‐term mortality. Our data provide further support to current anti‐inflammatory strategies for severe COVID‐19, including IL‐6 antagonists.
Combination of fermentation and enzymolysis enhances bioactive components and function of de‐oiled rice bran
Authors: Hou Meixin , Wu Jianmin , Miao Jingna , Zeng Hui , Liao Jinghong , Hang Suqin 
Published: July 2024

AbstractBACKGROUNDDe‐oiled rice bran (DORB), a substantial yet underutilized byproduct of rice processing, boasts a rich composition of active ingredients but suffers from limited application. Previous studies have indicated that enzymatic or fermentation treatments enhanced these active components. In this study, lactobacilli and complex enzymes were employed to co‐treat DORB, involving the determination of the changes in active components and functionalities of DORB extract (DORBE) before and after this treatment.RESULTSFollowing fermentation–enzymolysis, the total phenol and total flavonoid contents in DORBE were significantly increased by 43.59% and 55.10%, reaching 19.66 and 34.34 g kg−1, respectively. Antioxidant tests in vitro demonstrated that the co‐treatment enhanced the scavenging activities of DPPH, hydroxyl and ABTS radicals. Porcine intestinal epithelial cell experiments revealed that, compared to DORBE, the fermentation and enzymolysis DORBE (FDORBE) exhibited significantly improved cell viability and catalase activity as well as scavenging capacity for reactive oxygen species and malondialdehyde after induction by H2O2. Furthermore, FDORBE restored the decreased mRNA expression levels of Nrf2, HO‐1 and NQO1 in the nuclear factor erythroid 2‐related factor 2 (Nrf2) pathway stimulated by H2O2.CONCLUSIONFermentation–enzymolysis co‐treatment increases the contents of bioactive components of DORBE and enhances its antioxidant capacity, leading to a better protection against intestinal disorders induced by oxidative stress, suggesting that this co‐treatment is a rational and effective strategy to increase the value of grains and promotes the use of DORB as a functional feed in animal production. © 2024 Society of Chemical Industry.
The utility of intraoperative marrow margin frozen section in extremity bone sarcoma resection
Authors: Gazendam Aaron , Clever David , Zhang Liuzhe , Griffin Anthony , Tsoi Kim , Wunder Jay , Ferguson Peter 
Published: July 2024

AbstractBackground and ObjectivesIntraoperative frozen section analysis is commonly used to evaluate marrow margins during extremity bone sarcoma resections, but its efficacy in the era of magnetic resonance imaging is debated. This study aimed to compare the accuracy of intraoperative frozen section assessment with final pathology, assess its correlation with gross intraoperative margin assessment, and evaluate its impact on surgical decision making.MethodsConsecutive patients undergoing extremity bone sarcoma resections from 2010 to 2022 at a single sarcoma center were included. Intraoperative frozen section and gross margin assessments were compared to final pathology using positive predictive values (PPV) and negative predictive values (NPV). Changes in surgical decisions due to positive intraoperative margins were recorded.ResultsOf 166 intraoperative frozen section marrow margins, four were indeterminant/positive, with two false positive/indeterminant findings and two false negatives compared to final pathology. Gross intraoperative assessment had no false positives and two false negatives. Frozen section analysis yielded a PPV of 50% (95% confidence interval [CI]: 16%–84%) and NPV of 98.8% (95% CI: 97%–100%), while gross assessment had a PPV of 100% (95% CI: 16%–100%) and NPV of 98.8% (95% CI: 97%–100%). Positive frozen section margins led to additional resections in three of four cases.ConclusionsIntraoperative frozen section analysis did not offer added clinical value beyond gross margin assessment in extremity bone sarcoma resections. It exhibited a low PPV and led to unnecessary additional resections. Gross intraoperative assessment proved adequate for margin evaluation, potentially saving time and resources.
The influence of social media on tourist behavior
Authors: Chen Wuxiang , Zhu Yahui , Wang Jiajia , Liu Shanshan , Li Xiubai 
Published: July 2024

AbstractThis study explores the influence of the technology acceptance model (TAM) to identify the impact of social media use on the behavior of potential travelers. Data derived from 586 respondents to a recent survey carried out in Southern China suggest that: (a) tourists' perceptions of ease of use and their perceived interest in social media have a significant positive effect on attitudes toward using it; (b) the perceived usefulness of social media has a significant positive effect on attitudes toward using it; and (c) the positive effects of external factors such as subjective norms and interactivity on tourists' perceptions of its usefulness, ease of use and interest in social media have been verified. This study puts forward suggestions on the use of social media promotion and marketing in tourism destinations resulting from the survey.
Folic acid as a green inhibitor for corrosion protection of Q235 carbon steel in 3.5 wt% NaCl solution
Authors: Han Peng , Liu Zebang , Ren Zhichao , Li Yue , Sun Zhenwei , Xu Chenyang 
Published: July 2024

AbstractThis study combines experimental and theoretical explorations. The corrosion inhibition performance of different concentrations (50, 100, 250, and 500 ppm) of folic acid in 3.5 wt% NaCl solution on Q235 steel was tested by weight loss and electrochemical test. The corrosion inhibition efficiency increased with the gradual increase of folic acid concentration and reached a maximum of 87% at 500 ppm folic acid. The experimental results for electrochemistry and weight loss are in good agreement with the simulation calculations. The adsorption of folic acid on the steel surface obeyed the Langmuir isotherm, and the adsorption process was a combination of chemisorption and physisorption. The contact angle test also yielded the maximum increase in hydrophobicity of the specimen surface at the added folic acid concentration of 500 ppm. The corrosion morphology after the addition of corrosion inhibitor was relatively flat. The adsorption orientation of folic acid molecules on the steel surface in an aqueous environment was investigated using density functional theory (DFT)/molecular dynamics (MD) simulations. The microscopic mechanism of action of folic acid corrosion inhibitors is clarified.
The Neural Correlates of Central Auditory Dysfunction in Chronic Tinnitus: A Multimodal Approach
Authors: Nada Nashwa , El‐Tabbakh Amira Roshdy , Elgohary Mai Mohammed , Mandour Alaa Elsayed 
Published: July 2024

ObjectivesIt was aimed at assessing the connection between tinnitus and central auditory dysfunction using both central auditory tests (CATs) and diffusion tensor imaging (DTI) for brain regions that are crucial for central auditory processing.MethodsThis prospective case–control study included 15 patients with persistent tinnitus and 20 healthy volunteers as controls. They underwent CATs for memory, attention, and DTI. The Tinnitus Handicap Inventory (THI) Questionnaire was applied as well. From several brain regions, the values of mean diffusivity (MD) and fractional anisotropy (FA) were determined.ResultsComparing both groups, the tinnitus group showed statistically worse values as regards the CATs (memory for content, sequence memory, speech perception in noise (SPIN) at different signal‐to‐noise ratios, “SNRs”) compared with the control group. As regards DTI, the tinnitus group showed decreased FA in several brain areas, including the cingulum, prefrontal‐cortex (PFC), insula, and hippocampus. Furthermore, the tinnitus group showed significantly higher MD in the cingulum, BA‐46, and amygdala compared with the control group. FA values of BA‐46 were positively correlated with the SPIN‐SNR−10scores. Also, FA values of the middle cingulum were positively correlated with SPIN‐SNRzeroscores. MD values at BA‐46 were negatively correlated with SPIN‐SNR−10. THI scores were negatively correlated with FA at BA‐46; however, they were positively correlated with MD at the amygdala.ConclusionsCentral auditory dysfunction may be linked to the underlying neurophysiological changes in chronic tinnitus.Level of EvidenceLevel 2Laryngoscope, 2024
Role of land use, green energy, and water resources for food accessibility: Evidence from emerging economies in the lens of COP28
Authors: Amin Waqas , Xie Shouhong , Vasa László , Mentel Urszula 
Published: July 2024

AbstractIn the era of COP28, where most of the developed and developing economies concentrate more on the development of environmentally friendly energy resources to tackle the issue of climate change. Nevertheless, the literature lacks appropriate evidence regarding the influences of green energy and other resources on food security. This study analyses the influences of land use, green energy, and water resources on food accessibility in emerging economies, while also considering the important roles of natural resources, research and development (R&D) expenditure, and economic growth during 1980–2020. Due to non‐linear data dispersion, the novel moments quantile regression is employed. Results assert that land use has a positive significant influence on food accessibility in the presence of water resources and a weaker negative impact in the presence of natural resources. Natural and water resources are detrimental to food accessibility in the Emerging Seven (E7) countries. Furthermore, R&D expenditure and green energy positively (negatively), while economic growth negatively (positively) impacted food accessibility in the presence of natural resources (water resources). The results are robust and validate causal inferences that help develop appropriate policies for emerging economies concerning food accessibility or security. In this rapidly evolving era, most empirical studies consider environmental quality. Conversely, this study contributes to the literature by examining the factors influencing food accessibility, as this issue is of considerable importance because of the rapidly growing global population.
Polyampholytes with Various Charge Distributions: Conformation States via Computer Simulation
Authors: Kitina Polina V. , Glаgoleva Anna A. , Vasilevskaya Valentina V. 
Published: July 2024

AbstractBy means of molecular dynamics computer simulation, the conformational space of polyampholyte macromolecules with various distributions of the charged groups along the chain is studied. A coarse‐grained model where each monomer unit of the chain is presented as a non‐charged group in the backbone of the macromolecule connected with a charged side pendant is considered. A limiting case of fully charged chains in the isoelectric point is investigated. The oppositely charged monomer units are distributed in various patterns: regular alternating, multiblock, or random sequences. It is found that the chains with random unit distribution adopt much more compacted conformations than the chains with regular distributions with comparable block lengths. Calculating the chain size and its fluctuation along with the spatial density distribution, coil, and globular conformations are distinguished and arranged on the diagrams in terms of chain length, block length, and Bjerrum length.