bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment of central giant cell lesions using bisphosphonates with intralesional corticosteroid injections
Authors: da Silva Newton Guerreiro , Carreira Aline Semblano Dias , Pedreira Erick Nelo , Tuji Fabrício Mesquita , Ortega Karem López , de Jesus Viana Pinheiro João 
Published: August 2012

Abstract
Central giant cell lesions are benign intraosseous proliferative lesions that have considerable local aggressiveness. Nonsurgical treatment methods, such as intralesional corticosteroid injections, systemic calcitonin and interferon have been reported. Recently, bisphosphonates have been used to treat central giant cell lesions. A case of a 36-year-old male with a central giant cell lesion crossing the mandibular midline was treated with intralesional corticosteroids combined with alendronate sodium for the control of systemic bone resorption. The steroid injections and the use of bisphosphonates were stopped after seven months when further needle penetration into the lesion was not possible due to new bone formation. After two years, the bony architecture was near normal, and only minimal radiolucency was present around the root apices of the involved teeth. The patient was followed up for four years, and panoramic radiography showed areas of new bone formation. Thus far, neither recurrence nor side effects of the medication have been detected.
Effect of hypoxia on equine mesenchymal stem cells derived from bone marrow and adipose tissue
Authors: Ranera Beatriz , Remacha Ana Rosa , Álvarez-Arguedas Samuel , Romero Antonio , Vázquez Francisco José , Zaragoza Pilar , Martín-Burriel Inmaculada , Rodellar Clementina 
Published: August 2012

AbstractBackgroundMesenchymal stem cells (MSCs) derived from bone marrow (BM-MSCs) and adipose tissue (AT-MSCs) are being applied to equine cell therapy. The physiological environment in which MSCs reside is hypoxic and does not resemble the oxygen level typically used inin vitroculture (20% O2). This work compares the growth kinetics, viability, cell cycle, phenotype and expression of pluripotency markers in both equine BM-MSCs and AT-MSCs at 5% and 20% O2.ResultsAt the conclusion of culture, fewer BM-MSCs were obtained in hypoxia than in normoxia as a result of significantly reduced cell division. Hypoxic AT-MSCs proliferated less than normoxic AT-MSCs because of a significantly higher presence of non-viable cells during culture. Flow cytometry analysis revealed that the immunophenotype of both MSCs was maintained in both oxygen conditions. Gene expression analysis using RT-qPCR showed that statistically significant differences were only found forCD49din BM-MSCs andCD44in AT-MSCs. Similar gene expression patterns were observed at both 5% and 20% O2for the remaining surface markers. Equine MSCs expressed the embryonic markersNANOG,OCT4andSOX2in both oxygen conditions. Additionally, hypoxic cells tended to display higher expression, which might indicate that hypoxia retains equine MSCs in an undifferentiated state.ConclusionsHypoxia attenuates the proliferative capacity of equine MSCs, but does not affect the phenotype and seems to keep them more undifferentiated than normoxic MSCs.
TEG® and ROTEM® in trauma: similar test but different results?
Authors: Sankarankutty Ajith , Nascimento Bartolomeu , Teodoro da Luz Luis , Rizoli Sandro 
Published: August 2012

Abstract

Introduction
Transfusion in trauma is often empiric or based on traditional lab tests. Viscoelastic tests such as thromboelastography (TEG
®
) and rotational thromboelastometry (ROTEM
®
) have been proposed as superior to traditional lab tests. Due to the similarities between the two tests, general opinion seems to consider them equivalent with interchangeable interpretations. However, it is not clear whether the results can be similarly interpreted. This review evaluates the comparability between TEG and ROTEM and performs a descriptive review of the parameters utilized in each test in adult trauma patients.

Methods
PUBMED database was reviewed using the keywords “thromboelastography” and “compare”, between 2000 and 2011. Original studies directly comparing TEG
®
with ROTEM
®
in any area were retrieved. To verify the individual test parameter used in studies involving trauma patients, we further performed a review using the keywords “thromboelastography” and “trauma” in the PUBMED database.

Results
Only 4 studies directly compared TEG
®
with ROTEM
®
. One in liver transplantation found that transfusion practice could differ depending on the device in use. Another in cardiac surgery concluded that all measurements are not completely interchangeable. The third article using commercially available plasma detected clinically significant differences in the results from the two devices. The fourth one was a head-to-head comparison of the technical aspects. The 24 articles reporting the use of viscoelastic tests in trauma patients, presented considerable heterogeneity.

Conclusion
Both tests are potentially useful as means to rapidly diagnose coagulopathy, guide transfusion and determine outcome in trauma patients. Differences in the activators utilized in each device limit the direct comparability. Standardization and robust clinical trials comparing the two technologies are needed before these tests can be widely recommended for clinical use in trauma.
Twelve year experience of laparoscopic gastric plication in morbid obesity: development of the technique and patient outcomes
Authors: Talebpour Mohammad , Motamedi Seyed Mohammad Kalantar , Talebpour Atieh , Vahidi Hamed 
Published: August 2012

Abstract

Background
Laparoscopic Gastric Plication (LGP) is a new restrictive bariatric surgery, previously introduced by the author. The aim of this study is to explain the modifications and to present the 12-year experience, regarding early and long term results, complications and cost.

Methods
We used LGP for morbid obesity during the past 12 years. Anterior plication (10 cases), one-row bilateral plication while right gastroepiploic artery included (42 cases), and excluded from the plication (104 cases) and two-row plication (644 cases). The gastric greater curvature was plicated using 2/0 prolen from fundus at the level of diaphragm preserving the His angle to just proximal to the pylorus. The anatomic and functional volume of stomach was 50cc and 25cc respectively in two-row method. Ordered postop visits also included evaluation of weight loss, complications, change of diet and control of exercise.

Results
LGP was performed in 800 cases (mean age: 27.5, range: 12 to 65 years, nine under 18). Female to male ratio was 81% to 19% and average BMI was 42.1 (35-59). The mean excess weight loss (EWL) was 70% (40% to 100%) after 24 months and 55% (28% to 100%) after 5 years following surgery. 134 cases (16.7%) did not completed long term follow-up. The average time of follow up was 5 years (1 month to 12 years). 5.5% and 31% of cases complained from weight regain respectively during 4 and 12 years after LGP. The mean time of operation was 72 (49–152) minutes and average hospitalization time was 72 hours (24 hours to 45 days). The cost of operation was 2000 $ less than gastric banding or sleeve and 2500 $ less than gastric bypass. Eight patients out of 800 cases (1%) required reoperation due to complications like: micro perforation, obstruction and vomiting following adhesion of His angle. Other complications included hepatitis pneumonia, self-limiting intra-abdominal bleeding and hypocalcaemia.

Conclusion
The percentage of EWL in this technique is comparable to other restrictive methods. The technique is safe with 1.6% complication (1% reoperated), and 31% regain during 12 years. The cost of operation is less than the other methods.
A systematic review of genetic skeletal disorders reported in Chinese biomedical journals between 1978 and 2012
Authors: Cui Yazhou , Zhao Heng , Liu Zhenxing , Liu Chao , Luan Jing , Zhou Xiaoyan , Han Jinxiang 
Published: August 2012

Abstract
Little information is available on the prevalence, geographic distribution and mutation spectrum of genetic skeletal disorders (GSDs) in China. This study systematically reviewed GSDs as defined in “Nosology and Classification of genetic skeletal disorders (2010 version)” using Chinese biomedical literature published over the past 34 years from 1978 to 2012. In total, 16,099 GSDs have been reported. The most frequently reported disorders were Marfan syndrome, osteogenesis imperfecta, fibrous dysplasia, mucopolysaccharidosis, multiple cartilaginous exostoses, neurofibromatosis type 1 (NF1), osteopetrosis, achondroplasia, enchondromatosis (Ollier), and osteopoikilosis, accounting for 76.5% (12,312 cases) of the total cases. Five groups (group 8, 12, 14, 18, 21) defined by “Nosology and Classification of genetic skeletal disorders” have not been reported in the Chinese biomedical literature. Gene mutation testing was performed in only a minor portion of the 16,099 cases of GSDs (187 cases, 1.16%). In total, 37 genes for 41 different GSDs were reported in Chinese biomedical literature, including 43 novel mutations. This review revealed a significant imbalance in rare disease identification in terms of geographic regions and hospital levels, suggesting the need to create a national multi-level network to meet the specific challenge of care for rare diseases in China.
Cohesin is required for expression of the estrogen receptor-alpha (ESR1) gene
Authors: Prenzel Tanja , Kramer Frank , Bedi Upasana , Nagarajan Sankari , Beissbarth Tim , Johnsen Steven A 
Published: August 2012

Abstract

Background
In conjunction with posttranslational chromatin modifications, proper arrangement of higher order chromatin structure appears to be important for controlling transcription in the nucleus. Recent genome-wide studies have shown that the Estrogen Receptor-alpha (ERα), encoded by the ESR1 gene, nucleates tissue-specific long-range chromosomal interactions in collaboration with the cohesin complex. Furthermore, the Mediator complex not only regulates ERα activity, but also interacts with the cohesin complex to facilitate long-range chromosomal interactions. However, whether the cohesin and Mediator complexes function together to contribute to estrogen-regulated gene transcription remains unknown.

Results
In this study we show that depletion of the cohesin subunit SMC3 or the Mediator subunit MED12 significantly impairs the ERα-regulated transcriptome. Surprisingly, SMC3 depletion appears to elicit this effect indirectly by rapidly decreasing ESR1 transcription and ERα protein levels. Moreover, we provide evidence that both SMC3 and MED12 colocalize on the ESR1 gene and are mutually required for their own occupancy as well as for RNAPII occupancy across the ESR1 gene. Finally, we show that extended proteasome inhibition decreases the mRNA expression of cohesin subunits which accompanies a decrease in ESR1 mRNA and ERα protein levels as well as estrogen-regulated transcription.

Conclusions
These results identify the ESR1 gene as a cohesin/Mediator-dependent gene and indicate that this regulation may potentially be exploited for the treatment of estrogen-dependent breast cancer.
Implementation of a neonatal pain management module in the computerized physician order entry system
Authors: Mazars Nathalie , Milési Christophe , Carbajal Ricardo , Mesnage Renault , Combes Clémentine , Novais Aline Rideau Batista , Cambonie Gilles 
Published: August 2012

AbstractBackgroundDespite the recommended guidelines, the neonatal management of pain and discomfort often remains inadequate. The purpose of the present study was to determine whether adding a pain and discomfort module to a computerized physician order entry (CPOE) system would improve pain and discomfort evaluation in premature newborns under invasive ventilation.MethodsAll newborns <37 weeks gestational age (GA) and requiring invasive ventilation were included in a prospective study during two 6-month periods: before and after the inclusion of the pain and discomfort evaluation module. The main outcome measure was the percentage of patients having at least one assessment of pain and discomfort per day of invasive ventilation using the COMFORT scale.ResultsA total of 122 patients were included: 53 before and 69 after the incorporation of the module. The mean age was 30 (3) weeks GA. After the module was included, the percentage of patients who benefited from at least one pain and discomfort assessment per day increased from 64% to 88% (p < 0.01), and the mean number (SD) of scores recorded per day increased from 1 (1) to 3 (1) (p < 0.01). When the score was not within the established range, the nursing staff adapted analgesia/sedation doses more frequently after module inclusion (53% vs. 34%,p < 0.001). Despite higher mean doses of midazolam after module introduction [47 (45) vs. 31 (18) μg/kg/hr,p < 0.05], the durations of invasive ventilation and hospital stay, and the number of nosocomial infections, were not significantly modified.ConclusionsAdding a pain and discomfort tool to the CPOE system was a simple and effective way to improve the systematic evaluation of premature newborns who required ventilatory assistance.
The role of BCL11B in hematological malignancy
Authors: Huang Xin , Du Xin , Li Yangqiu 
Published: August 2012

Abstract
The B-cell leukemia/lymphoma 11B (BCL11B) gene is a member of the BCL family which plays a crucial role in the development, proliferation, differentiation and subsequent survival of T cells. BCL11B gene alterations are related to malignant T cell transformation that occurs in hematological malignancies. Remarkably, the BCL11B gene is responsible for the regulation of the apoptotic process and cell proliferation. This review summarizes current data and knowledge concerning the alteration of BCL11B in hematological malignancies and its role as a potential target for therapies directed against T cell malignancies.
The active electrosensory range ofGymnotus omarorum
Authors: Pereira Ana Carolina , Aguilera Pedro , Caputi Angel A. 
Published: August 2012

SUMMARYThis article reports a biophysical and behavioral assessment of the active electrolocation range of Gymnotus omarorum. Physical measurements show that the stimulus field of a point on the sensory mosaic (i.e. the potential positions in which an object may cause a significant departure of the transcutaneous field from basal in the absence of an object) consists of relatively extended volumes surrounding this point. The shape of this stimulus field is dependent on the position of the point on the receptive mosaic and the size of the object. Although the limit of stimulus fields is difficult to assess (it depends on receptor threshold), departure from the basal field decays rapidly, vanishing at about 1.5 diameters for conductive spheres. This short range was predictable from earlier theoretical constructs and experimental data. Here, we addressed the contribution of three different but synergetic mechanisms by which electrosensory signals attenuate with object distance. Using novelty responses as an indicator of object detection we confirmed that the active electrosensory detection range is very short. Behavioral data also indicate that the ability to precisely locate a small object of edible size decays even more rapidly than the ability to detect it. The role of active electroreception is discussed in the context of the fish's habitat.
Resolvins D1, D2, and Other Mediators of Self-Limited Resolution of Inflammation in Human Blood following n-3 Fatty Acid Supplementation
Authors: Mas Emilie , Croft Kevin D , Zahra Paul , Barden Anne , Mori Trevor A 
Published: August 2012

Abstract

BACKGROUND
Resolvins and protectins are families of local lipid mediators generated from the n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) during self-limited resolution of inflammation. We aimed to develop a liquid chromatography–tandem mass spectrometry (LC-MS/MS) assay to measure these lipid mediators in human blood following n-3 fatty acid supplementation and to determine whether the blood collection method affects their measured concentration.

METHODS
Blood samples from 20 healthy volunteers enrolled in an n-3 fatty acid supplementation trial were collected in EDTA, heparin, or citrate, or prepared as serum after volunteers had undergone 3 weeks of supplementation. Plasma or serum was purified by solid-phase chromatography and analyzed with LC-MS/MS.

RESULTS
The assay identified 18R/S-hydroxy-5Z,8Z,11Z,14Z,16E-eicosapentaenoic acid (18R/S-HEPE); 17S-hydroxy-4Z,7Z,10Z,13Z,15E,19Z-docosahexaenoic acid (17R/S-HDHA); 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid (RvD1); 7S,8R,17R-trihydroxy-4Z,9E,11E,13Z,15E19Z-docosahexaenoicacid (17R-RvD1); 7S,16R,17S-trihydroxy-4Z,8E,10Z,12E,14E,19Z-docosahexaenoic acid (RvD2); 10S,17S-dihydroxy-4Z,7Z,11E,13Z,15E,19Z-docosahexaenoicacid (10S,17S-DiHDHA); and 10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid (protectin D1, PD1). The limits of detection and quantification were 3 pg and 6 pg on-column, respectively. The pathway precursors 18R/S-HEPE and 17R/S-HDHA, but not the resolvins, were lower in serum compared with plasma. After n-3 fatty acid supplementation, mean (SD) EDTA plasma concentrations were: 18R/S-HEPE 386 (56) pg/mL, 17R/S-HDHA 365 (65) pg/mL, RvD2 26 (4) pg/mL, RvD1 31 (5) pg/mL, and 17R-RvD 161 (7) pg/mL. 10S,17S-DiHDHA and PD1 concentrations were below the limit of quantification.

CONCLUSIONS
This is the first study reporting 17R/S-HDHA, RvD1, and RvD2 concentrations measured in human blood following oral n-3 fatty acid supplementation. The concentrations of the antiinflammatory lipid mediators RvD1 and RvD2 were within the biological range known to have antiinflammatory and proresolving activities in isolated human leukocytes and in in vivo studies in mice.
Compressed Transformation of Korean Film Industry from Old to New Regime
Authors: Noh Kwang Woo 
Published: August 2012

Abstract
Korean film business was constructed during the Japanese Occupation era (1910 1945). Under the situation that Japanese immigrants owned all theaters, Koreans managed to produce local films based on a distinct culture and history. From the Sino-Japanese War (1937) to the end of World War II, Korean local films fell into war propaganda film and were even suspended. From the end of WWII to the Korean War (1950 1953), the base of the Korean film business was almost destroyed. From 1954 to 1973, the Korean film business developed rapidly and was so prosperous that this era was called the South Korean Golden Age. But the establishment of Park Chung-hee's military dictatorship regime (1973) tightened its control of society including the film business. Besides, the nationwide spread of television made Korean film business stagnate from the 1970s to the mid 1980s.
Collecting the Ashes of Time: The Temporality and Materiality of Industrial Ruins in Wang Bing's West of the Tracks
Authors: Zhang Ling 
Published: August 2012

Abstract
The enigmatic and evocative characteristics of ruins (for example, ruined monuments, gardens, tombs, or steles) and the visual representations of ruins by painting, photography, and cinema, have been explored and elucidated by philosophers, theorists, art historians, and film scholars over decades or even centuries. The romantic tendency to aestheticize ruins in terms of their innate beauty as objects of venerable decay (Schonle, 2006: 649-669; Makarius, 2004: 81, 84, 108) has been contested by Walter Benjamin (Benjamin, 1977) in the modern period, since war catastrophes and human disasters which have resulted in vast ruins in the 20th Century make the aesthetic appreciation of ruins problematic.
Beyond South of the Border: A Textual Analysis of the Taiwanese Blockbuster Cape No.7
Authors: Su Chiaoning 
Published: August 2012

Abstract
Cape No. 7 (2008) was the most extraordinary cultural phenomenon to sweep Taiwan in 2008. From its debut on Aug. 22, 2008 to its close on Dec. 12, 2008, Cape No.7, a locally produced low-budget movie, not only achieved the longest theatrical release in Taiwanese cinematic history, stretching to 16 weeks, but also earned US$ 15.5 million in box office sales, becoming Taiwan's second highest-grossing movie of all time, trailing only to Titanic (Li, 2008).
Spectatorships, Pleasures, and Social Uses of Cinema: A Tentative Study of the Reception of Cape No 7
Authors: Shiau Hong-Chi 
Published: August 2012

Abstract
Cape No. 7 seems to have a simple storyline despite the large number of characters: essentially the story involves a Mandarin-speaking fashion model from Japan assigned the difficult task of managing a hastily assembled band comprising seven untrained locals. Not only in the movie, is the journey to success of the band a "miracle," but the marketing of the movie itself is a miracle as well1. The unusual music-comedy genre, strong character development, and localized humor are all important to the content of the movie (Hu, 2008; Cape No. 7 official site). The characterization in the film is especially impressive, as the characters are presented as rounded individuals with multi-faceted personalities.
Beyond Fuller and M.A.S.H.: Korean War Representations in Film, Genre, and Comic Strip
Authors: Williams Tony 
Published: August 2012

Abstract
Like that popular definition of the Korean War, most Hollywood representations appear to be as "forgotten" as the still relevant implications of the actual conflict. Exceptions do exist such as the early 50s films of Samuel Fuller - The Steel Helmet (1950) and Fixed Bayonets (1951 -- as well as M*A*S*H. (1970) that led to the popular CBS television series version that ran from 1972-1983. However, these films generally received attention as works of film "auteurs," while Altman's M*A*S*H received acclaim more as an allegory of the Vietnam War that was occurring at the time of production than a representation of the earlier conflict. However, cinematic representations of Korea were scarce in comparison to earlier and later representations of conflict.
Music and Meaning in the Independence-Era Malaysian Films of P. Ramlee
Authors: McGraw Andrew Clay , Suriyanti Azmi Azti Nezia 
Published: August 2012

Abstract
Independence-era Malaysia boasted a robust film industry that produced hundreds of films per year between the late 1950s and early 1960s. The multiinstrumentalist, singer, composer, actor, and director P. Ramlee was the most productive and popular figure in this scene. Today Ramlee is lauded as one of Malaysia's and Singapore's most important cultural figures. In this article we argue that Ramee's film music served to score the topography of ethnic relations in independence-era Malaysia. In Ramlee's films, which featured almost exclusively Malay casts and cultural contexts, inter-ethnic relations were heard more often than seen. Ramlee's music stood in a complex if sometimes contradictory relationship to the representation of modern Malay culture and class in his films. While upper class Westernized Malay characters were inevitably portrayed as betraying traditional values, Westernized Malay music (and vice versa) served as the soundtrack for modern, working class Malaysians rooted in traditional cultural mores.
Revisiting the Tale of Obasute in the Japanese Imagination
Authors: Lee Wood-hung , Shaw Yomei 
Published: August 2012

Abstract
In 1983, Japanese director Imamura Shôhei's film The Ballad of Narayama (Narayama bushikô1) gained international recognition by winning the Palme d'Or prize at the Cannes Film Festival. The film was based on a well-known Japanese novel of the same name, written by Fukasawa Shichirô in 1956,2 depicting a rural village where an elderly woman, Orin, stoically prepares to make her final journey to a sacred mountaintop where she will await death, after the village custom. The earthy realism of the film's portrayal of the harsh world of the farming village both shocked and touched critics (Kehr, 1997: 85-86; Lardeau, 1997: 157-158; Tesson, 1997: 159-163). Imamura's film was not, however, the first to adapt Fukasawa's novel for the screen. Earlier, in 1958, Kinoshita Keisuke had also directed a film3 based on the same novel, in a very different style which incorporated elements of traditional Japanese theatre.