bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jamming partner selection for maximising the worst D2D secrecy rate based on social trust
Authors: Wang Li , Wu Huaqing 
Published: October 2015

AbstractDevice‐to‐device (D2D) communications have recently attracted broad attention, owing to its potential ability to improve spectrum and energy efficiency within the existing cellular infrastructure. Without sophisticated control, D2D users themselves are not powerful enough to resist eavesdropping or fight against security attacks. This work investigates how to select jamming partners for D2D users to thwart eavesdroppers by exploiting social relationship with the help of full channel state information (CSI) and partial CSI, respectively. We aim to maximise the worst‐case eavesdropping by selecting jammer node and allocating transmit power for both source and jammer nodes. We first present a heuristic genetic algorithm‐based solution to address the problem. We then propose low‐complexity optimisation solutions by considering the upper and lower bounds of power allocation. Numerical results show that the proposed schemes can achieve better performance through finding an appropriate partner. Copyright © 2015 John Wiley & Sons, Ltd.
Sparse representation of HCP grayordinate data reveals novel functional architecture of cerebral cortex
Authors: Jiang Xi , Li Xiang , Lv Jinglei , Zhang Tuo , Zhang Shu , Guo Lei , Liu Tianming 
Published: October 2015

AbstractThe recently publicly released Human Connectome Project (HCP) grayordinate‐based fMRI data not only has high spatial and temporal resolution, but also offers group‐corresponding fMRI signals across a large population for the first time in the brain imaging field, thus significantly facilitating mapping the functional brain architecture with much higher resolution and in a group‐wise fashion. In this article, we adopt the HCP grayordinate task‐based fMRI (tfMRI) data to systematically identify and characterize task‐based heterogeneous functional regions (THFRs) on cortical surface, i.e., the regions that are activated during multiple tasks conditions and contribute to multiple task‐evoked systems during a specific task performance, and to assess the spatial patterns of identified THFRs on cortical gyri and sulci by applying a computational framework of sparse representations of grayordinate brain tfMRI signals. Experimental results demonstrate that both consistent task‐evoked networks and intrinsic connectivity networks across all subjects and tasks in HCP grayordinate data are effectively and robustly reconstructed via the proposed sparse representation framework. Moreover, it is found that there are relatively consistent THFRs locating at bilateral parietal lobe, frontal lobe, and visual association cortices across all subjects and tasks. Particularly, those identified THFRs locate significantly more on gyral regions than on sulcal regions. These results based on sparse representation of HCP grayordinate data reveal novel functional architecture of cortical gyri and sulci, and might provide a foundation to better understand functional mechanisms of the human cerebral cortex in the future. Hum Brain Mapp 36:5301–5319, 2015. © 2015 Wiley Periodicals, Inc.
Integrated risk and recovery monitoring of ecosystem restorations on contaminated sites
Authors: Hooper Michael J , Glomb Stephen J , Harper David D , Hoelzle Timothy B , McIntosh Lisa M , Mulligan David R 
Published: October 2015

Abstract
Ecological restorations of contaminated sites balance the human and ecological risks of residual contamination with the benefits of ecological recovery and the return of lost ecological function and ecosystem services. Risk and recovery are interrelated dynamic conditions, changing as remediation and restoration activities progress through implementation into long-term management and ecosystem maturation. Monitoring restoration progress provides data critical to minimizing residual contaminant risk and uncertainty, while measuring ecological advancement toward recovery goals. Effective monitoring plans are designed concurrently with restoration plan development and implementation and are focused on assessing the effectiveness of activities performed in support of restoration goals for the site. Physical, chemical, and biotic measures characterize progress toward desired structural and functional ecosystem components of the goals. Structural metrics, linked to ecosystem functions and services, inform restoration practitioners of work plan modifications or more substantial adaptive management actions necessary to maintain desired recovery. Monitoring frequency, duration, and scale depend on specific attributes and goals of the restoration project. Often tied to restoration milestones, critical assessment of monitoring metrics ensures attainment of risk minimization and ecosystem recovery. Finally, interpretation and communication of monitoring findings inform and engage regulators, other stakeholders, the scientific community, and the public. Because restoration activities will likely cease before full ecosystem recovery, monitoring endpoints should demonstrate risk reduction and a successional trajectory toward the condition established in the restoration goals. A detailed assessment of the completed project's achievements, as well as unrealized objectives, attained through project monitoring, will determine if contaminant risk has been minimized, if injured resources have recovered, and if ecosystem services have been returned. Such retrospective analysis will allow better planning for future restoration goals and strengthen the evidence base for quantifying injuries and damages at other sites in the future. Integr Environ Assess Manag 2016;12:284–295. © 2015 The Authors. Integrated Environmental Assessment and Management Published by Wiley Periodicals, Inc. on behalf of SETAC.
Key Points
Successful restoration of contaminated sites requires monitoring to document progress in ecological recovery and risk reduction. Through integrated contaminant and ecological monitoring, we identify impediments and trigger management actions that attain desired remediation and restoration goals. Long-term monitoring contributes to the state of restoration science by better informing restoration planning, improving outcomes, and increasing confidence in the restoration of contaminated ecosystems.
Development of recombinant collagen‐peptide‐based vehicles for delivery of adipose‐derived stromal cells
Authors: Parvizi Mojtaba , Plantinga Josée A. , van Speuwel‐Goossens Carolina A.F.M. , van Dongen Elisabeth M.W.M. , Kluijtmans Sebastiaan G.J.M. , Harmsen Martin C. 
Published: October 2015

AbstractStem cell therapy is a promising approach for repair, remodeling and even regenerate tissue of otherwise irreparable damage, such as after myocardial infarction (aMI). A severe limitation of cardiac stem cell therapy is the generally poor retention of administered cells in the target tissue. In tissue repair the main mode of action of adipose tissue‐derived stem cells (ADSC) is the production of various growth factors, cytokines, anti‐inflammatory and anti‐apoptotic factors that together augment repair, remodeling, and regeneration. In this experiment, we used recombinant collagen peptide (RCP) with additional integrin‐binding motives and different crosslinkers. Formulated as 50–100 μm microspheres with bound ADSC, we hypothesized that this would improve ADSC retention and function. Crosslinking was performed with chemical crosslinkers (EDC and HMDIC) at high and low concentrations or by thermal treatment (DHT). ADSC adhesion, proliferation, apoptosis/necrosis, and gene expressions in two‐dimensional and three‐dimensional were analyzed. In addition, the effect of ADSC conditioned medium (ADSC‐CM) on proapoptotic/sprouting HUVEC was examined. Our results show that all materials support cell adhesion in short time point, however, EDC‐High crosslinker induced ADSC apoptosis/necrosis. Gene expression results revealed lower expression of proinflammatory genes in chemical crosslinked materials, despite EDC‐High the proinflammatory genes expressions were similar or higher than TCPS. In addition, cultured ADSC on DHT crosslinked RCP showed a proinflammatory phenotype compared to TCPS. Sprouting assay results confirmed the protective effect of ADSC‐CM derived from TCPS and HMDIC‐High crosslinked RCP proapoptotic HUVEC. We conclude that ADSC adhere to the materials and maintain their therapeutic profile. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 503–516, 2016.
Gate replacement with PMOS stacking for leakage reduction in VLSI circuits
Authors: Panwar Uday , Khare Kavita 
Published: October 2015

SummaryScaling down the circuits of complementary metal oxide semiconductor increases the leakage current. Input vector control is an extremely popular method for controlling leakage without using any technological modification. However, it is less effective for larger logic depth circuits.Our study proposes a Worst Leakage State (WLS) free‐node algorithm based on gate replacement technique, in which, when the logic gate of a given circuit goes into WLS, it is replaced by a suitable variant of the gate which in turn reduces the leakage current in an idle mode of the circuit at the same input vector. These variants minimize leakage under WLS conditions. For replacement purpose, four variants (V1–V4) of a two‐input NAND gate are proposed. This technique is applied on different circuits and some benchmark circuits such as ISCAS'85 (C17) and ITC'99 (B01, B02 and B06) (total of 10 circuits), according to the proposed algorithm with variants V1–V4. The average total power is reduced to 15.04%, 15.04%, 35.7% and 31.5%, and the leakage current is reduced to 42.96%, 42.96%, 84.25% and 84.52%, respectively, for variants V1–V4. The average delay is decreased by 16.03% in V1 and V2 variants and increased by 7.74% and 13.16% for variants V3 and V4, respectively, as compared with the results of conventional circuits at 45‐nm Berkeley Predictive Technology Model technology. Copyright © 2015 John Wiley & Sons, Ltd.
Automated generation of node‐splitting models for assessment of inconsistency in network meta‐analysis
Authors: van Valkenhoef Gert , Dias Sofia , Ades A. E. , Welton Nicky J. 
Published: October 2015

Network meta‐analysis enables the simultaneous synthesis of a network of clinical trials comparing any number of treatments. Potential inconsistencies between estimates of relative treatment effects are an important concern, and several methods to detect inconsistency have been proposed. This paper is concerned with the node‐splitting approach, which is particularly attractive because of its straightforward interpretation, contrasting estimates from both direct and indirect evidence. However, node‐splitting analyses are labour‐intensive because each comparison of interest requires a separate model. It would be advantageous if node‐splitting models could be estimated automatically for all comparisons of interest.We present an unambiguous decision rule to choose which comparisons to split, and prove that it selects only comparisons in potentially inconsistent loops in the network, and that all potentially inconsistent loops in the network are investigated. Moreover, the decision rule circumvents problems with the parameterisation of multi‐arm trials, ensuring that model generation is trivial in all cases. Thus, our methods eliminate most of the manual work involved in using the node‐splitting approach, enabling the analyst to focus on interpreting the results. © 2015 The Authors Research Synthesis Methods Published by John Wiley & Sons Ltd.
mTHPC mediated, systemic photodynamic therapy (PDT) for nonmelanoma skin cancers: Case and literature review
Authors: Horlings Rudolf K. , Terra Jorrit B. , Witjes Max J.H. 
Published: October 2015

Background and ObjectivePatients with multiple nonmelanoma skin cancers (NMSCs), like immunosuppressed or nevoid basal cell carcinomas, offer a therapeutic challenge. Photodynamic therapy (PDT) using the systemic photosensitizer meta‐tetrahydroxyphenylchlorin (mTHPC) has the ability to treat multiple NMSCs up to a depth of 10 mm in a single session. These unique properties offer an attractive alternative to regular therapies (e.g., surgery or radiation) to these patients.Study DesignA systemic search was carried out that focused on the main clinical studies using mTHPC‐PDT on NMSCs in humans. This review describes some of the basic principles of the treatment, the most effective treatment parameters as well as its possible adverse outcomes, which is illustrated with a short description of our own experiences using this treatment modality on four patients with multiple NMSCs.ResultsTo date, only four clinical studies have been published. It was demonstrated that mTHPC‐PDT could be highly effective. On illuminating 1–2 days after drug administration, plasma drug levels were high and the tumor clearance rates were high (up to 100%), with relative few side effects and excellent cosmetic and functional outcomes. These results were obtained with a relatively low, patient friendly photosensitizer dose (0.04–0.05 mg/kg) as skin photosensitivity was shorter after the procedure. Although the patients personally experienced consistently good cure rates, the healing times varied greatly between anatomical areas. The head and neck areas heal well with good cosmesis, while the lower leg and foot areas show delayed, at times compromised, healing with scarring.ConclusionsAlthough mTHPC‐PDT is described in the literature as an interesting and promising therapeutic option, especially for multiple NMSCs, a randomized clinical trial is lacking and personal experiences warrant too much skepticism. With the recent introduction of the hedgehog pathway inhibitor vismodegib, mTHPC‐PDT seems to be less suitable as a first line of treatment; it should be considered as a last resort therapy. Lasers Surg. Med. 47:779–787, 2015. © 2015 Wiley Periodicals, Inc.
Caregiver Contribution to Heart Failure Self‐Care (CACHS)
Authors: Harkness Karen , Buck Harleah G. , Arthur Heather , Carroll Sandra , Cosman Tammy , McGillion Michael , Kaasalainen Sharon , Kryworuchko Jennifer , O'Keefe‐McCarthy Sheila , Sherifali Diana , Strachan Patricia H. 
Published: October 2015

AbstractAimWhile caregivers (CGs) make an important contribution to the self‐care of heart failure (HF) patients, there are no reliable and valid tools for measuring such contributions. Current interventions that strive to optimize patient outcomes through self‐care strategies neglect to account for CG contributions, a potential confounder on outcomes. The aim of the study was to develop an instrument that measures CG contributions to HF patients’ self‐care.DesignThe study design follows an established process for instrument development.MethodsA systematic literature review and semi‐structured interviews of CGs were conducted to identify measureable CG activities. Items were derived from thematic analysis of CG narratives. A content validity index was computed for each item (I‐CVI). Items with an I‐CVI of >0·70 were retained. Items with an I‐CVI of 0·50–0·70 were revised for clarification and items with an I‐CVI <0·5 were discarded, except in instances where fulsome theoretical or empirical evidence supported their retention.Results14 CGs completed interviews and 10 CGs with 4 expert nurses completed I‐CVI testing. Major interview themes included arranging appointments, medication adherence, monitoring, coordinating care, encouraging independence and taking action. A total of 36 items were constructed and underwent I‐CVI testing. Following I‐CVI testing, 27 items were retained, seven items were retained after revision based on CG feedback and two items were removed. This newly developed 34‐item questionnaire represents current literature, CGs’ experiences, excellent I‐CVI scores and ready for further psychometric testing.
Probiotic supplementation attenuates increases in body mass and fat mass during high‐fat diet in healthy young adults
Authors: Osterberg Kristin L. , Boutagy Nabil E. , McMillan Ryan P. , Stevens Joseph R. , Frisard Madlyn I. , Kavanaugh John W. , Davy Brenda M. , Davy Kevin P. , Hulver Matthew W. 
Published: October 2015

ObjectiveThe objective was to determine the effects of the probiotic, VSL#3, on body and fat mass, insulin sensitivity, and skeletal muscle substrate oxidation following 4 weeks of a high‐fat diet.MethodsTwenty non‐obese males (18‐30 years) participated in the study. Following a 2‐week eucaloric control diet, participants underwent dual X‐ray absorptiometry to determine body composition, an intravenous glucose tolerance test to determine insulin sensitivity, and a skeletal muscle biopsy for measurement of in vitro substrate oxidation. Subsequently, participants were randomized to receive either VSL#3 or placebo daily during 4 weeks of consuming a High‐fat (55% fat), hypercaloric diet (+1,000 kcal day−1). Participants repeated all measurements following the intervention.ResultsBody mass (1.42 ± 0.42 kg vs. 2.30 ± 0.28 kg) and fat mass (0.63 ± 0.09 kg vs. 1.29 ± 0.27 kg) increased less following the High‐fat diet in the VSL#3 group compared with placebo. However, there were no significant changes in insulin sensitivity or in vitro skeletal muscle pyruvate and fat oxidation with the High‐fat diet or VSL#3.ConclusionsVSL#3 supplementation appears to have provided some protection from body mass gain and fat accumulation in healthy young men consuming a High‐fat and high‐energy diet.
Ischemia reperfusion-facilitated sinusoidal endothelial cell injury in liver transplantation and the resulting impact of extravasated platelet aggregation
Authors: Miyashita T. , Nakanuma S. , Ahmed A.K. , Makino I. , Hayashi H. , Oyama K. , Nakagawara H. , Tajima H. , Takamura H. , Ninomiya I. , Fushida S. , Harmon J.W. , Ohta T. 
Published: October 2015

Summary

Background
The exact sequence of events leading to ultimate hepatocellular damage following ischemia/reperfusion (I/R) is incompletely understood. In this article, we review a mechanism of organ dysfunction after hepatic I/R or immunosuppressive treatment, in addition to the potential of liver sinusoidal endothelial cell (LSEC) protection and antiplatelet treatment for the suppression of hepatocellular damage.

Methods
A review of the literature, utilizing PubMed-NCBI, was used to provide information on the components necessary for the development of hepatocellular damage following I/R.

Results
It is well-established that LSECs damage following hepatic I/R or immunosuppressive treatment followed by extravasated platelet aggregation (EPA) is the root cause of organ dysfunction in liver transplantation. We have classified three phases, from LSECs damage to organ dysfunction, utilizing the predicted pathogenic mechanism of sinusoidal obstruction syndrome. The first phase is detachment of LSECs and sinusoidal wall destruction after LSECs injury by hepatic I/R or immunosuppressive treatment. The second phase is EPA, accomplished by sinusoidal wall destruction. The various growth factors, including thromboxane A2, serotonin, transforming growth factor-beta and plasminogen activator inhibitor-1, released by EPA in the Disse’s space of zone three, induce portal hypertension and the progression of hepatic fibrosis. The third phase is organ dysfunction following portal hypertension, hepatic fibrosis, and suppressed liver regeneration through various growth factors secreted by EPA.

Conclusion
We suggest that EPA in the space of Disse, initiated by LSECs damage due to hepatic I/R or immunosuppressive treatment, and activated platelets may primarily contribute to liver damage in liver transplantation. Endothelial protective therapy or antiplatelet treatment may be useful in the treatment of hepatic I/R following EPA.
Genetic Counseling Milestones: A Framework for Student Competency Evaluation
Authors: Guy Carrie 
Published: October 2015

AbstractGraduate medical education has recently increased focus on the development of medical specialty competency milestones to provide a targeted tool for medical resident evaluation. Milestones provide developmental assessment of the attainment of competencies over the course of an educational program. An educational framework is described to explore the development of Genetic Counseling Milestones for the evaluation of the development of genetic counseling competencies by genetic counseling students. The development of Genetic Counseling Milestones may provide a valuable tool to assess genetic counseling students across all program activities. Historical educational context, current practices, and potential benefits and challenges in the development of Genetic Counseling Milestones are discussed.
Microstructure of Interpass Rolled Wire + Arc Additive Manufacturing Ti-6Al-4V Components
Authors: Martina Filomeno , Colegrove Paul A. , Williams Stewart W. , Meyer Jonathan 
Published: October 2015

Abstract
Mechanical property anisotropy is one of the issues that are limiting the industrial adoption of additive manufacturing (AM) Ti-6Al-4V components. To improve the deposits’ microstructure, the effect of high-pressure interpass rolling was evaluated, and a flat and a profiled roller were compared. The microstructure was changed from large columnar prior

$$\beta $$

β

grains that traversed the component to equiaxed grains that were between 56 and 139 μm in size. The repetitive variation in Widmanstätten

$$\alpha $$

α

lamellae size was retained; however, with rolling, the overall size was reduced. A “fundamental study” was used to gain insight into the microstructural changes that occurred due to the combination of deformation and deposition. High-pressure interpass rolling can overcome many of the shortcomings of AM, potentially aiding industrial implementation of the process.
Intervención educativa sobre el nivel de conocimientos en pacientes con diabetes y baja o nula escolaridad
Authors: López López Erika , Ortiz Gress Alicia Armida , López Carbajal Mario Joaquín 
Published: October 2015

Objetivo: Evaluar una intervención integral de educación en diabetes sobre el nivel de conocimientos en pacientes con dicha enfermedad.
Método: Diseño cuasiexperimental con 17 pacientes diagnosticados de diabetes que refirieron ser analfabetos o contar con una educación básica y pertenecer a la comunidad Villa Aquiles Serdán, Pachuca, Hidalgo. Entre julio y diciembre de 2013, se aplicó una encuesta para identificar sexo, edad, escolaridad, ocupación, estado civil y tiempo de evolución, y solicitamos la medición de hemoglobina glucosilada. Los conocimientos sobre diabetes se midieron mediante el Diabetes Knowledge Questionnaire (pretest y postest). Se realizó estadística descriptiva y comparación de medias a través de la t de Student.
Resultados: El 64.7% fueron mujeres; el 41.2% fueron amas de casa; respecto a la escolaridad, el 17.6% era analfabeta; la media de edad fue de 52.6 ± 5.8 a˜nos (rango 39-72). La media del tiempo con diabetes fue de 112.00 ± 59.1 meses (rango 1-180). El 88.2% no había tomado un curso previamente. El 58.8% no pertenecían a ningún grupo de ayuda mutua; para el resto, el promedio de tiempo en el grupo fue de 156 meses (rango 6-156). La intervención mostró diferencias estadísticamente significativas en el nivel de conocimientos en el 70.8% de los ítems: información básica (p < 0.000), sobre el control (p < 0.000) y complicaciones (p < 0.000), y a nivel general (p < 0.000). Respecto a los niveles de hemoglobina glucosilada, la media de la diferencia fue de 1.01 mg/dL ± 1.77 mg/dL (p = 0.053).
Conclusiones: La intervención mostró cambios significativos en los niveles de conocimientos sobre información básica, el control y las complicaciones. Asimismo, en el promedio de conocimientos en general. La hemoglobina glucosilada no mostró diferencias estadísticamente significativas. Es importante continuar con intervenciones educativas integrales que incluyan aspectos nutricionales, psicológicos, médicos, farmacológicos y tener estrategias culturalmente competentes.