bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methyl orange sorption on octadecylamine-modified iron oxide magnetic nanoparticles
Authors: Tianhui Liang , Aga-Tagieva Sayara , Omelyanchik Alexander , Xiaozhou Zhang , Lu Hong , Levada Katerina , Rodionova Valeria , Magomedov Kurban 
Published: August 2024

This study investigates the sorption of 2-methyl orange dye onto octadecylamine-modified iron oxide magnetic nanoparticles (ODA-IONPs). The synthesized ODA-IONPs exhibit remarkable sorption capacity, reaching 800 mg/g at the nanoparticle concentrations ranging from 5 to 10 mg/g and pH of 2–8. The sorption process demonstrates rapid kinetics, achieving 90% of maximum sorption within 0.5 min. Thermodynamic analysis showed that sorption process is spontaneous and endothermic, as indicated by negative ΔG and positive ΔH values. The pseudo-second-order and Langmuir models best describe the sorption kinetics at 293 K (R² 0.99). Compared to other adsorbents, ODA-IONPs show superior MO removal capacity under a wider pH range. The influence of nanoparticle concentration, pH, and temperature on sorption efficiency is systematically explored, with optimal conditions identified at 10 mg/L ODA-IONPs and pH 6. Furthermore, the feasibility of nanoparticle reusability for sorption purposes is assessed. These findings underscore the potential of ODA-IONPs as efficient sorbents for wastewater treatment and environmental remediation applications.
A repeated strike loading organ culture model for studying compression-associated chronic disc degeneration
Authors: Li Baoliang , Chen Xu , Chen Hongkun , Zhang Fu , Li Jianfeng , Zhu Zhengya , Tang Tao , Gao Manman , Li Nianhu , Ma Liang , Zhou Zhiyu 
Published: August 2024

Mechanical stress has been viewed as one of the key risk factors in accelerating the intervertebral disc degeneration process. The goal of the present study was to employ a repeated strike loading bovine caudal disc system to elucidate the pathophysiological impacts of cumulative mechanical stress on the disc. The discs in the model groups were subjected to two different mechanical stresses: one strike loading or repeated strike loading. The following indices were analyzed: histological morphology, glycosaminoglycan release, disc height, cell viability, apoptosis-related protein expression, and catabolism-related gene expression. Both mechanical stress modes induced degenerative changes in the discs by day 11, such as clefts and delamination of the annulus fibrosus; they increased glycosaminoglycan release. Cell viability was significantly decreased and catabolic gene expression was significantly up-regulated in the degenerative loading group and repeated strike loading group by day 9. These alterations remained evident in the annulus fibrosus tissue of the repeated strike loading group on day 11. Our data suggests that the repeated strike loading model adopted in this study could lead to degenerative changes in the disc organ model. Annulus fibrosus cells displayed a more noticeable response to mechanical stress damage and a slower recovery process, suggesting that the annulus fibrosus serves as a pivotal factor in disc degeneration due to mechanical stress injuries. The study also indicates that due to the gradual self-repair of intervertebral disc cells after injury, it is necessary to apply repeated strike loading on the disc at specific intervals when researching the repair of chronic disc injuries.
The Thai Folk Game “Jik Sen” has Become a Recreational Sport for Older People in Senior Citizen Schools
Authors: Tongterm Tachapon , Chimphali Khanittha , Pongthanu Metawut , Pengseesang Thanyaporn , Kaewma Jeeranan , Namboonlue Sarocha 
Published: August 2024

Objectives. The purposes of this study were to: 1) develop an exercise program incorporating the Thai recreational sport “Jik Sen” for older people in senior citizen schools; 2) investigate the effects of the exercise program incorporating the Thai recreational sport “Jik Sen” on the physical fitness of older people in senior citizen schools; and 3) assess the satisfaction level of older people with the exercise program incorporating the Thai recreational sport “Jik Sen”.
Materials and methods. This was a two-group experimental study including the experimental group of 17 people (65.53 ± 3.43 years) and the control group of 17 people (65.76 ± 3.60 years). The participants in this study were healthy individuals aged 60 years and above, who were actively engaged in the elderly school program. They were selected using a purposive sampling method and subsequently assigned them to the experimental and control groups using a matching method based on BMI. The research tools consisted of the exercise program, which incorporated the Thai recreational sport “Jik Sen” developed by the research team, and the Senior Fitness Test (SFT). For a period of 8 weeks, the experimental group involved in an exercise regimen comprising 60 minutes of daily training in the Thai recreational sport “Jik Sen”, with a frequency of 3 days per week. The control group was instructed to maintain their normal daily routine and did not participate in any physical activities or exercise programs during the experiment. The data were analyzed using mean, standard deviation, percentage, and t-test.
Results. 1) The exercise program incorporating the Thai recreational sport “Jik Sen” for older people in senior citizen schools can be appropriately used to promote exercise and sports in elderly schools in Thailand. The IOC value was 0.97. 2) A significant difference was observed in the mean scores of the 8-foot up-and-go test between the pre-experimental (mean = 7.94, S.D. = 1.34) and post-experimental (after 8 weeks) (mean = 6.70, S.D.= 0.79) periods for the experimental group at the level of 0.05. The mean scores of the 8-foot up-and-go test between the control group (mean = 7.84, S.D. = 1.16) and the experimental group (mean = 6.70, S.D. = 0.79) were also found to be significantly different at the level of 0.05. 3) The experimental group expressed high levels of satisfaction with the exercise program involving the Thai recreational sport “Jik Sen” for older people in senior citizen schools, with a mean score of 4.62 ± 0.51 points.
Conclusion. The exercise program incorporating the Thai recreational sport "Jik Sen" can effectively enhance the dynamic balance of older individuals in senior citizen schools. Furthermore, it has been shown to facilitate social interaction, improve cognitive abilities including thinking and planning skills, and promote enjoyment.
Analysis of long-term results of conservative and surgical treatment in patients with locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinuses
Authors: Zhao J. , Mudunov A. M. , Aliyeva S. B. , Kamolova F. Sh. , Stelmakh D. K. , Gelfand I. M. 
Published: August 2024

Introduction. Surgical intervention with subsequent chemoradiation therapy is one of the treatment standards in squamous cell carcinoma of the nasal cavity and paranasal sinuses. However, the question of the optimal therapy for this pathology remains open.Aim. To compare treatment results in patients with locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinuses after conservative and surgical treatment.Materials and methods. The study included 86 patients with squamous cell carcinoma of the nasal cavity and paranasal sinuses, stages III–Iva, who between 2000 and 2020 received treatment at the N.N. Blokhin National medical Research Oncology Center. Surgical treatment with subsequent radiation or chemoradiation therapy was performed in 31 patients, conservative treatment (radiation or chemoradiation therapy) was performed in 55 patients.Results. Five-year overall survival in the conservative treatment group was 46.2 %, in the surgical treatment group – 59.7 % (р = 0.081); 5-year progression-free survival was 17 and 50.5 %, respectively (p = 0.002). In patients with Т3N0 tumor who received surgical treatment, 5-year progression-free survival was significantly higher than in patients who received conservative treatment (p <0,05). Comparison of overall survival and progression-free survival of patients who achieved objective response (complete response + partial response) after conservative treatment (n =36) and after surgical treatment (n = 31) did not show statistically significant differences (р = 0.469 and р = 0.183, respectively). The overall 5-year survival rate in the salvage surgery treatment group (24/55) was 63.1 % compared with 59.7 % in the surgical treatment group (n = 31), there were also no significant differences (p = 0.95). In patients with T3 tumor who received conservative treatment in this study, higher risk of progression was observed compared to patients who underwent surgical treatment.Conclusion. Surgical intervention remains an important treatment method for patients with locally advanced squamous cell carcinoma of the nasal cavity and paranasal sinuses, especially in cases of smaller tumor extent. Conservative therapy seems promising but large-scale prospective controlled randomized clinical trials are necessary to confirm its effectiveness and safety in various patient groups.
Treatment of dirofilariosis in the practice of the head and neck tumor departments (clinical observation)
Authors: Fedina M. S. , Gorchak Yu. Yu. , Titova A. V. , Romanova E. S. , Sadovnikova O. A. , Reshetov D. N. , Ter-Ovanesov M. D. 
Published: August 2024

Nowadays, doctors of almost all specializations have to deal with patients who have one or another voluminous formations of the skin and subcutaneous tissue with localization in the head and neck region, which are heterogeneous in their etiology. It’s important to remember that sometimes neoplasms can turn out to be a manifestation of an infectious disease, in particular helminthosis. One of the representatives from this group of diseases is dyrofilariasis, is a zoonotic transmissible tropical helminth disease caused by roundworms – filarias of the genus Dirofilaria, which parasitize in humans mainly in the subcutaneous tissue and lymphatic system. A single filariasis of the Dirofilaria repens type is found in humans in temperate regions of Russia. Generally, dirofilariosis imitates the clinical picture of some other non-parasitic disease. Because of the lack of awareness of this disease among doctors, the process of making a diagnosis is almost always difficult. Often the correct diagnosis is only made during surgical treatment.The article presents a clinical observation of dirofilariosis with lesions subcutaneous tissue of the dorsum nose.
Clinical and economic assessment of using IRS®19 for the treatment and prevention of acute respiratory infections in children
Authors: Kolbin A. S. , Kasimova A. R. 
Published: August 2024

Objective: to perform pharmacoeconomic analysis of the feasibility of using topical bacterial lysate in the form of nasal spray (IRS®19) for the treatment and prevention of upper respiratory tract infections in pediatric population in comparison with other drugs registered in Russia, belonging to the class of topical interferons.Material and methods. Based on the Rosstat data and information from open sources, the population of patients with acute respiratory infections (ARI) was calculated. Considering the Russian clinical recommendations “Acute respiratory viral infection (ARVI)” and “Acute tonsillitis and pharyngitis (acute tonsillopharyngitis)”, the direct medical costs of providing medical care to specialized patients were determined. Direct costs on the part of parents included all costs for purchasing medicines for basic or concomitant therapy. Direct costs on the part of the healthcare system and the state included the costs of providing medical care at the outpatient stage. Direct non-medical costs included payments for disability leaves, indirect costs – lost gross domestic product (GDP) due to absence from work.Results. The total costs of the healthcare system and the state for 1 AVI patient are 42,472 rubles in case of uncomplicated course and 70,649 rubles in case of complicated course. In case of IRS®19 application from the first day of the disease, it is possible to reduce its duration by more than two-fold. Thus, the costs of medical care amount to 2,078 rubles. Payments for disability leaves by the Social Fund of Russia will amount to 2,287 rubles, and the lost GDP – 9,148 rubles (total costs 13,513 rubles).Conclusion. For the first time in Russian economic conditions, the use of IRS®19 for ARI treatment and prevention in children was evaluated. IRS®19 application from the first symptoms of the disease allows refusing the use of topical interferons, reduces the duration of symptoms and the need for prescription of antitussives, vasoconstrictors, and antibiotics.
Approaches to determining the cost of laboratory tests
Authors: Khayrullin I. I. , Omelyanovskiy V. V. , Gostishchev R. V. , Sukhorukikh O. A. , Kovaleva S. A. , Gorodetsky B. G. 
Published: August 2024

Background. Determining the cost of laboratory tests is a significant factor in the context of economic analysis and management of clinical diagnostic laboratories. Information about costs allows medical organizations to plan operational activities more efficiently, optimize resource utilization, and exercise control over expenditures. These measures are aimed at improving the financial position and enhancing the operational efficiency of the laboratories.Objective: to review various methods for calculating the cost of laboratory tests.Material and methods. The study included the collection and analysis of publications on calculating cost of laboratory tests, determining their prime cost in PubMed/MEDLINE and Google Scholar databases, as well as in Google and Yandex search engines for similar “cost laboratory test” query. The regulatory documents of the Russian Federation in this area were considered.Results. For calculating the prime cost of laboratory tests such methods as direct costing, regulatory prime costing, total prime costing, activity-based costing (ABC), standard costing, costing for base service, department costing, cost-volume analysis are used. The ABC and standard cost methods provide the most accurate assessment of the impact of various factors.Conclusion. The approaches established by regulatory documents do not contradict each other and represent the implementation of total costing method. At the same time, a medical organization may use other methods for calculating the cost of laboratory tests, depending on the objectives of the analysis, the specifics of the laboratory and the cost accounting method adopted in accounting policy, the management accounting system.
Inflammatory Biomarkers in Patients With Type 2 Diabetes Mellitus and Heart Failure With Preserved Ejection Faction
Authors: Sveklina T. S. , Shustov S. B. , Kolyubaeva S. N. , Kuchmin A. N. , Kozlov V. A. , Oktysyuk P. D. , Konyaev V. V. 
Published: August 2024

Aim. To verify the relationship between gene polymorphisms of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) with inflammation markers and codependent metabolic variables in patients with type 2 diabetes mellitus and chronic heart failure (CHF).Material and methods. This study included 154 patients (mean age, 69.1±3.2 years). The control group consisted of 47 patients with metabolic syndrome (MS) without CHF; the 2nd group included 56 patients with CHF with preserved ejection fraction (CHFpEF); and the 3rd group consisted of 51 patients with CHF with reduced ejection fraction (CHFrEF). The rs1800629 polymorphism of the TNF-α gene (TNF-α: G308A) was studied in real time by the polymerase chain reaction (PCR) method and the rs1800795 polymorphism of the IL-6 gene (IL-6: 174 G>C) was studied by PCR with the electrophoretic detection. The frequencies of polymorphic alleles were compared with the clinical blood test results, plasma concentrations of C-reactive protein (CRP), TNF-α, leptin, and fibrinogen. Differences between the groups were determined using the F test. Relationships between individual studied parameters were identified using the regression analysis.Results. In most patients, the occurrence of gene polymorphisms was eident as increased plasma concentrations of biomarkers. An association was found between the TNF-α gene polymorphism (G308A) and an increase in plasma TNF-α and between the IL-6 gene polymorphism (174 C>G) and an increase in plasma CRP. In the CHFpEF group, the rs1800629 gene polymorphism was observed in 55% of patients, among whom 93% had increased TNF-α. The rs1800795 gene polymorphism was observed in 82% of CHFpEF patients, among whom 21% had increased CRP. In the CHFrEF group, the G308A transition in the TNF-α gene was observed in 53% of patients; an increase in the respective cytokine was noted in 67% of patients; the IL-6 gene polymorphism 174 C>G was found in 78%, however, only 14% of patients with this polymorphism had also increased CRP. In the control group, the TNF-α G308A gene polymorphism was found in 30% of patients, while an increase in free TNF-α was associated with this polymorphism in 50% of patients; the IL-6 174 C>G gene polymorphism was detected in 78%, while no increase in the CRP level was observed in this group. This demonstrates a high probability of the TNF-α G308A gene polymorphism occurrence in patients with CHF.Conclusion. Inflammatory markers are important predictors of CHF. The most significant predictor was the TNF-α G308A gene polymorphism, which was observed in more than 50% of patients, the majority of whom had an increase in plasma TNF-α
Factors that Determined a Positive Response to Resynchronization Therapy in Patients With Chronic Heart Failure and Cardiac Dyssynchrony. One Center Experience
Authors: Postol A. S. , Neminushchiy N. M. , Antipov G. N. , Ivanchenko A. V. , Lyashenko V. V. , Kalinin D. A. , Kotov S. N. , Vygovsky A. B. , Shneider Yu. A. 
Published: August 2024

Aim. To evaluate the efficacy of cardiac resynchronization therapy (CRT) in patients with chronic heart failure (CHF) associated with cardiac dyssynchrony and to identify the factors that influence the CRT efficacy.Material and methods. This retrospective study included 155 patients after implantation of CRT devices. The CRT devices with a built-in cardioverter-defibrillator (CRT-D) and without it (CRT-P) were implanted in 139 (89.7%) and 16 (10.3%) patients, respectively. The follow-up period was 52.37±35.94 months. Based on the study results, two groups of patients were formed depending on the presence of a clinical response to CRT, responders and non-responders. The factors that influenced the clinical response to CRT were studied. The effect of the baseline state of patients on the effect of therapy was assessed. The need for CRT optimization and a possibility of using electrocardiographic criteria for that purpose were studied. Modern devices and leads for CRT, their functional capabilities and their influence on the CRT efficacy were characterized. Statistical analysis was performed with an IBM SPSS Statistics 21.0 (Chicago, USA) package.Results. CRT implantation with the left ventricular lead placement according to the traditional technique, through the coronary sinus, was successful in 130 (87.9%) patients. Difficulties with the left ventricular lead placement were noted in 13 (8.3%) patients when other techniques were used. After 6 months, a hemodynamic and clinical response was observed in 112 (72.2%) patients, and no positive response in 43 (27.8%). The increase in left ventricular ejection fraction in the responder group was more than 21.8±3.7%, which was associated with an improvement of the 6-minute walk test results. Th clinical response was significantly influenced by the possibility of stimulation from the basal parts of the heart; the use of more modern devices for CRT and quadripolar left ventricular leads; timely CRT optimization; and persistent dyssynchrony in non-responders. During the follow-up period, 34 (21.9%) patients died. The death rate in the non-responder group was significantly higher than in the responder group, 18 (41.3%) vs. 16 (14.3%), p=0.001. The main cause of death in the group of non-responders was CHF. Heart transplantation was performed in 3 (1.9%) patients.Conclusion. CRT increases the life span and improves the quality of life in patients with CHF and cardiac dyssynchrony. There was a group of patients with no benefit from CRT in this study. Modern devices allow increasing the number of patients who benefit from CRT. Periodic optimization of CRT is necessary. When optimizing CRT, it is possible to use electrocardiographic criteria of effectiveness: duration of the QRS complex and changes in the position of the electrical axis of the heart.
The effect of education through a mobile application on self-care behavior in patients undergoing percutaneous coronary: A randomized clinical trial
Authors: Salavati Khatereh , Rejeh Nahid , Rohani Farhad , Nayeri Alireza Dehghan 
Published: August 2024

Background & Aim: Patients who receive percutaneous coronary interventions often display inadequate levels of self-care actions, which could create difficulties in managing the disease and achieving favorable treatment results. This study investigates the impact of using an educational mobile application on self-care behaviors in patients undergoing percutaneous coronary intervention.
Methods & Materials: A randomized clinical trial was conducted with 110 patients undergoing percutaneous coronary interventions at Shahid Rajaei Hospital in Karaj, Iran, in 2023. The study enrolled and assigned them to either the intervention group (n=55) or the control group (n=55) by block randomization. In addition to training upon discharge, the experimental group received educational resources via a mobile phone application. The data collection instruments included MSCBS. Patients completed the MSCBS before the intervention and 4 weeks later. The data were analyzed with SPSS 21. The study's level of significance was set to P<0.05.
Results: Before the intervention, there was no significant difference in the self-care scores and the subscales between the two groups (P<0.05). Nonetheless, After the intervention, a significant difference was observed in the self-care scores and the subscales between the control and intervention groups, (p=0.001), and the difference in scores between the control and intervention groups increased significantly after the intervention and the scores of the intervention group had a significant increase compared to the scores of the control group.
Conclusion: The study showed that the mobile phone educational application could improve self-care behaviors in patients undergoing percutaneous coronary interventions. Therefore, it can be recommended that nurses working in medical centers use this educational application to enhance self-care in these patients.