bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prognostic analysis of further axillary dissection in breast cancer with 1-2 positive sentinel lymph nodes undergoing mastectomy
Authors: Zhao Xueyi , Yang Liu , Cao Congbo , Song Zhenchuan 
Published: August 2024

BackgroundThe ACOSOG Z0011 study has shown that axillary lymph node dissection (ALND) is an option to be considered in patients who had 1-2 metastatic sentinel lymph nodes (SLNs) who proceed with breast-conserving along with postoperative radiotherapy. However, there remains controversy regarding the applicability of this approach in patients who had a mastectomy. The aim of our study is to determine the prognostic differences and risk factors associated with the decision to opt for ALND in breast cancer patients who had 1-2 metastatic SLNs who receive a mastectomy.MethodsThe study conducted a retrospective analysis of patients diagnosed with cT1-2N0 breast cancer and treated at The Fourth Hospital of Hebei Medical University between January 2016 and December 2021, and patients were divided into two cohorts according to whether ALND was performed after sentinel lymph node biopsy (SLNB): SLNB cohort and SLNB + ALND cohort. Outcomes included the locoregional recurrence rate (LRR), disease-free survival (DFS), and overall survival (OS). Propensity score matching (PSM) was conducted to ensure the balance of variables between the two cohorts. Cox proportional hazard models were employed to ascertain the univariate and multivariate relative risks associated with survival.ResultsThere were 812 cases enrolled. After the PSM, 234 receiving ALND and 234 not receiving ALND were matched. A median follow-up period of 56.72 ± 20.29 months was observed. During that time, no significant difference was identified in the DFS and OS in the SLNB + ALND cohort and the SLNB cohort (P = 0.208 and P = 0.102), except for those under 40 years old, SLNB + ALND group showed a reduction in LRR compared to SLNB group (11.1% vs. 2.12%, P = 0.044). Multivariate Cox analysis showed that younger (≤ 40 years), progesterone receptor (PR)-negative, and SLNB alone were independent risk factors for LRR; perineural invasion was a risk factor, while endocrinotherapy was a beneficial prognostic indicator for DFS and OS among patients with positive hormone receptor.ConclusionALND does not impact DFS and OS in patients with 1-2 metastatic SLNs who have completed a mastectomy. Being younger (≤ 40 years), having a negative PR, and undergoing SLNB alone were independent risk factors for LRR. Given this finding, we recommend avoiding axillary treatment such as ALND or radiotherapy in patients without risk factors.
Exploration of the intracellular chiral metabolome in pediatric BCP-ALL: a pilot study investigating the metabolic phenotype of IgH locus aberrations
Authors: Collins Meghan , Gorgoglione Ruggiero , Impedovo Valeria , Pan Xingxin , Chakkarai Sathyaseelan , Yi S. Stephen , Lodi Alessia , Tiziani Stefano 
Published: August 2024

Background and aimsAberrations in the immunoglobulin heavy chain (IgH) locus are associated with poor prognosis in pediatric precursor B-cell acute lymphoblastic leukemia (BCP-ALL) patients. The primary objective of this pilot study is to enhance our understanding of the IgH phenotype by exploring the intracellular chiral metabolome.Materials and methodsLeukemia cells were isolated from the bone marrow of BCP-ALL pediatric patients at diagnosis. The samples’ metabolome and transcriptome were characterized using untargeted chiral metabolomic and next-generation sequencing transcriptomic analyses.ResultsFor the first time D- amino acids were identified in the leukemic cells’ intracellular metabolome from the bone marrow niche. Chiral metabolic signatures at diagnosis was indicative of a resistant phenotype. Through integrated network analysis and Pearson correlation, confirmation was obtained regarding the association of the IgH phenotype with several genes linked to poor prognosis.ConclusionThe findings of this study have contributed to the understanding that the chiral metabolome plays a role in the poor prognosis observed in an exceptionally rare patient cohort. The findings include elevated D-amino acid incorporation in the IgH group, the emergence of several unknown, potentially enantiomeric, metabolites, and insights into metabolic pathways that all warrant further exploration.
The relationship between school bullying victimization and social mindfulness in middle school students: a chain mediating model of self-concept clarity and cognition reappraisal
Authors: Yang Weijing , Hu Dong , Guo Ying 
Published: August 2024

ObjectiveTo determine the relationship between school bullying victimization and social mindfulness and its mechanism in light of the interdependence and schema theories.MethodThe Chinese version of the Delaware Bullying Victimization Scale-student, Emotion Regulation Questionnaire, Self-Concept Clarity Scale and The Social Mindfulness Self-report Scale (SMSRS) were distributed to 553 middle school students.Results(1) The correlations of school bullying victimization with social mindfulness, self-concept clarity, and cognition reappraisal were statistically significant. (2) School bullying victimization had a significant effect on social mindfulness. (3) The simple mediating role of self-concept clarity and cognition reappraisal between school bullying victimization and social mindfulness were significant. (4) Self-concept clarity and cognition reappraisal played a chain mediating role between school bullying victimization and social mindfulness.
Sustainable potato farming in Shandong Province, China: a comprehensive analysis of organic fertilizer applications
Authors: Zhang Meiling , Xu Xuanguo , Ning Wenping , Zhang Fuhong , Sarkar Apurbo 
Published: August 2024

IntroductionThe potato holds the distinction of being the world’s largest non-cereal food crop and ensuring its sustainable production is imperative for global food security. Notably, China leads in both the planting area and output of potatoes globally, cementing its crucial role in the nation’s agricultural economy. A scientific assessment of the effectiveness of organic fertilizers on potato cultivation can significantly contribute to the promotion of sustainable agriculture.MethodsThis study utilizes a Propensity Score Matching (PSM) model and introduces a novel cost-efficiency approach to analyze and evaluate the production efficiency and economic impact of organic fertilizer application among 546 potato growers in Shandong.ResultsThe research findings reveal the following: Firstly, compared to the control group without organic fertilizer application, it is evident that the use of organic fertilizers enhances production technology efficiency, labor productivity, land productivity, and net profit per unit by 3.6%, 1588.47 kg/person, 16346.77 kg/ha, and 16135.32 yuan/ha, respectively. Secondly, an examination of cost efficiency among growers with different production scales indicates that those with a planting scale of 0.667-1.333 hectares demonstrate relatively high production efficiency across multiple factors. Additionally, there is an observable inverted U-shaped trend in the relationship between planting scale and production efficiency. Thirdly, the continuous application of organic fertilizers proves advantageous in mitigating inefficiencies in investment techniques, leading to cost savings and efficiency improvements in potato cultivation.DiscussionConsequently, it is recommended that the government and relevant departments enhance technical support, elevate professional training programs, and optimize the allocation of input factors. These measures aim to encourage farmers to adopt organic fertilizers, thereby promoting sustainable agricultural practices.
Use of protexin as a probiotic-supplemented feed additive: assessment of growth, digestibility, serum antioxidant enzyme activity, and blood profile in Cirrhinus mrigala
Authors: Riaz Danish , Hussain Syed Makhdoom , Sarker Pallab K. , Ali Shafaqat , Naeem Adan , Naeem Eman , Nazish Nadia , Al-Anazi Khalid Mashay , Farah Mohammad Abul 
Published: August 2024

IntroductionProbiotics, one of functional feed additives (FFAs), have emerged as a potential supplement to strengthen fish health and mitigate oxidative stress. The main focus of our research was to explore the benefits of probiotics (protexin) on growth, digestibility, antioxidant enzyme activity, and blood indices of Cirrhinus mrigala fingerlings.MethodsA total of 105 fish (7.42 ± 0.02 g/fish) were used in a 90-day feeding trial. Fish were fed two times a day, and diets were tested in triplicate tanks (15 fingerlings per tank). Moringa oleifera seed meal was chosen as a basal feed ingredient. Seven test diets were formulated: One was control (without supplement), and six diets had different concentrations of probiotics, such as 0.5, 1, 1.5, 2, 2.5, and 3 g kg−1.ResultsThe results of growth and nutrient absorption were maximum at a probiotic concentration of 2 g kg−1. The optimal serum antioxidant enzyme activity and blood parameters were likewise obtained at a probiotic dose of 2 g kg−1.ConclusionsSupplementing C. mrigala with 2 g kg−1 probiotics substantially improved their growth, nutrient digestibility, antioxidant enzyme activity, and hematological indices (p &lt; 0.05).
Hypoactivity and neurochemical alterations in the basal ganglia of female Sprague-Dawley rats after repeated exposure to atrazine
Authors: Acevedo-Huergo Triana , Sánchez-Yépez Jonathan , Mendoza-Trejo María Soledad , Hernández-Plata Isela , Giordano Magda , Rodríguez Verónica Mireya 
Published: August 2024

The herbicide atrazine (ATR) has been one of the most widely used herbicides worldwide. However, due to its indiscriminate use, it has been considered an environmental contaminant. Several studies have classified ATR as an endocrine disruptor, and it has been found to have neurotoxic effects on behavior, along with alterations in the dopaminergic, GABAergic, and glutamatergic systems in the basal ganglia of male rodents. These findings suggest that these neurotransmitter systems are targets of this herbicide. However, there are no studies evaluating the neurotoxicity of ATR in female rodents. Our study aimed to assess the effects of repeated IP injections of 100 mg ATR/kg or a vehicle every other day for 2 weeks (six injections) on the locomotor activity, content of monoamines, GABA, glutamate, and glutamine in the striatum, nucleus accumbens, ventral midbrain, and prefrontal cortex, and tyrosine hydroxylase (TH) protein levels in striatum and nucleus accumbens of female rats. Repeated 100 mg ATR/kg injections immediately decreased all the locomotor activity parameters evaluated, and such hypoactivity persisted for at least 48 h after the last ATR administration. The ATR administration increased dopamine and DOPAC content in the nucleus accumbens and the dopamine and DOPAC and serotonin and 5-HIAA content in the ventral midbrain. In contrast, the TH protein levels in the striatum and nucleus accumbens were similar between groups. Meanwhile, GABA, glutamine, and glutamate levels remained unaltered in all brain regions evaluated. The observed behavioral alterations could be associated with the monoamine changes presented by the rats. These data reveal that the nucleus accumbens and ventral midbrain are susceptible to repeated ATR exposure in female rats.
In vitro elution of amikacin, cefazolin, gentamicin, ampicillin/sulbactam, and meropenem from a commercially available calcium sulfate delivery kit
Authors: Maxwell Elizabeth A. , Howell Taylor , Mester Rachel , Bennett R. Avery , Cruz-Espindola Crisanta , Boothe Dawn 
Published: August 2024

IntroductionThe use of implantable antibiotic beads has become a frequent treatment modality for the management of surgical site infections in human and veterinary medicine. The objective of this study is to describe the elution kinetics of five antibiotics from a commercially available calcium sulfate antibiotic delivery kit. A secondary goal was to compare elution concentrations with minimal inhibitory concentrations (MIC) for commonly encountered bacteria from the University of Florida’s veterinary microbiology laboratory database.MethodsCalcium sulfate powder was combined with amikacin, cefazolin, gentamicin, ampicillin/sulbactam, and meropenem. Triplicates of three antibiotic-loaded beads were immersed in 5 mL of phosphate-buffered saline (PBS) and kept at 37°C under constant agitation. Antibiotic-conditioned PBS was sampled at 14 time points from 1-h to 30 days and analyzed by liquid chromatography to determine the antibiotic concentration.ResultsAll beads eluted concentrations of antibiotics for the 30-day sampling period, except for ampicillin/sulbactam, with the most antibiotics being eluted within the first week. The concentration of antibiotics within the eluent within the first 3–9 days (3- and 5-mm beads, respectively) was greater than the MIC of common isolates. The 5 mm bead samples were superior in maintaining higher concentrations for a longer period, compared to the 3-mm beads.DiscussionCSH beads eluted antibiotics over the 30-day course of the study. Most of the antibiotic elution occurred within the first week and was maintained above the MIC of commonly encountered isolates. This information may be useful for clinical decision making for treatment of local infections encountered in practice.
Monoclonal Anti-PCSK9 Antibodies: Real-World Data
Authors: Guidotti Giulia , Liberati Viola , Sorrentino Andrea , Lotti Elena , Crudele Felice , Rogolino Angela , Sammartino Aniello , Slanzi Margherita , Gori Anna Maria , Marcucci Rossella , Berteotti Martina 
Published: August 2024

Background: Real-world data on the use of lipid-lowering therapy (LLT) in clinical practice show that about 80% of (very) high-cardiovascular (CV)-risk patients disregard the 2019 European Society of Cardiology (ESC) Guidelines’ recommendations on dyslipidemias. The availability of proprotein convertase subtilisin/kexin type 9 monoclonal antibodies (PCSK9mAb) should reduce this gap. Our aim was to provide data on PCSK9mAb use in clinical practice, investigating the achievement of the ESC Guidelines’ recommendations in the real world. Methods: Between April 2018 and December 2022, patients who started on PCSK9mAb therapy (140 mg of evolocumab or 75 mg or 150 mg of alirocumab, subcutaneous injection every 2 weeks) were included in a prospective registry. Our cohort consisted of 256 patients: 95 (37.1%) were women (mean age: 65.43 ± 11.12 yrs), 53 (20.7%) were at high CV risk, and 203 (79.3%) were at very high CV risk. Results: After one year of PCSK9mAb treatment, nearly 60% of patients demonstrated full adherence to the ESC Guidelines’ recommendations, defined as achieving at least a 50% reduction in low-density lipoprotein cholesterol (LDL-C) levels along with reaching LDL-C target levels (≤55 and ≤70 mg/dL for very high and high risk, respectively). Concomitant high-dose statin therapy emerged as the primary predictor of LDL-C target attainment. Heterozygous familial hypercholesterolemia (HeFH), statin intolerance, and female gender were associated with a significant lower probability of achieving LDL-C target levels. Conclusions: Our analysis confirms that PCSK9mAb treatment is safe and effective, enabling 60% of our cohort to fully achieve the LDL-C guideline recommendations. The use of high-intensity statins emerged as a significant predictor of efficacy. Conversely, familial hypercholesterolemia and female gender were identified as predictors of therapeutic failure. Hence, it is crucial to address disparities in cardiovascular disease prevention between genders and to enhance strategies for managing elevated LDL-C in HeFH patients.
Los conocimientos legitimados y lo común y lo diverso en documentos curriculares de la provincia de Buenos Aires.
Authors: Mendez Karlovich Maricruz 
Published: August 2024

El siguiente artículo presenta algunos hallazgos vinculados a la colonialidad/decolonialidad curricular a partir del análisis de los conocimientos y saberes legitimados y los sentidos construidos alrededor de lo común y lo diverso en los Diseño Curricular de Nivel Superior para los niveles inicial y primario (2008) y del Marco Curricular Referencial (2018) de la provincia de Buenos Aires.
Diferentes aportes teóricos y metodológicos nos permiten reconocer la vigencia e insistencia de la colonialidad y la necesidad de trabajar permanentemente en su develamiento y deconstrucción, asumiendo que el curriculum puede alentar la construcción de otras subjetividades, a partir del reconocimiento de los modos diversos de ser, estar y conocer.
Desde las epistemologías del Sur y desde una mirada decolonial, recurrimos a la sociología de las ausencias y las emergencias para identificar lo producido como no existente y las posibilidad emergentes que pueden irrumpir / insurgir / transgredir las construcciones hegemónicas.
continuidad en el poder de agrupaciones sindicales
Authors: Vieira Gravina Alejandro Andrés 
Published: August 2024

En muchos sindicatos argentinos las agrupaciones oficialistas (también llamadas “listas”) han logrado perpetuarse en el poder indefinidamente, sin embargo la literatura aborda brevemente el fenómeno. Aprovechando esta vacancia el presente proyecto propone un estudio de caso explicativo sobre la Unión Ferroviaria para indagar los mecanismos que sostienen la continuidad de estas agrupaciones. Por lo tanto, la pregunta es: ¿qué mecanismos utiliza la “lista verde” para continuar en el poder? La hipótesis es la siguiente: el oficialismo posee dos mecanismos que aseguran su continuidad, reglas electorales hostiles a opositores (en especial para elecciones nacionales) y un intercambio de favores entre delegados y afiliado. El estudio está circunscripto al AMBA y al periodo 2013 – 2020.
Para comprobar la hipótesis se utiliza como herramienta metodológica la entrevista semiestructurada y para constatar la información obtenida se apela a discursos y entrevistas periodísticas a dirigentes, delegados y trabajadores como fuente secundaria de datos.
CONOCIMIENTO DISCIPLINAR Y FORMADORES DE PROFESORES DE LA ENSEÑANZA DEL INGLÉS COMO LENGUA EXTRANJERA
Authors: Quintana Marcela , Ramos Lucía , Díaz Claudio , Tangle Tania , Alarcón Paola 
Published: August 2024

El objetivo del estudio fue determinar de manera preliminar, cómo un grupo de formadores de profesores entienden el conocimiento disciplinar basado en su formación académica y experiencia docente. Este estudio plantea la hipótesis de que los formadores de profesores en la universidad, a) Conocen de lo que se trata el conocimiento disciplinar en el área de su experticia, es decir, inglés como lengua extranjera (EFL) y b) Estar en conocimiento de las diferentes disciplinas que constituyen el conocimiento disciplinar en el área de inglés como lengua extranjera. Los resultados se analizan no solo en términos de cómo estos formadores de profesores entienden el conocimiento disciplinar, sino también con respecto a las implicaciones pedagógicas y curriculares.
Agencia, espacios persistentes y valor patrimonial en paisajes de canteras-taller de Antofagasta de la Sierra (Catamarca, Argentina)
Authors: Bobillo Federico 
Published: August 2024

Las canteras-taller conforman paisajes que son socialmente significativos y tradicionales. El objetivo de este trabajo fue analizar el surgimiento de un paisaje social en un área de canteras-taller de Antofagasta de la Sierra (provincia de Catamarca, Argentina), considerando la diversidad de contextos arqueológicos relevados, el uso reiterado y persistentes de las áreas de actividad y las materialidades heterogéneas que se generaron como resultado de las prácticas sociales y logísticas desarrolladas por los grupos cazadores-recolectores en el marco de sus tareas de aprovisionamiento. Asimismo, interesó reflexionar sobre el valor patrimonial que poseen estos paisajes, ya que suelen carecer de visibilidad frente a otros sitios, como las cuevas con arte rupestre y grandes construcciones arquitectónicas que conforman poblados o aldeas, por ejemplo. Como parte de esta investigación se efectuaron prospecciones sistemáticas, relevamientos y muestreos de contextos líticos y rasgos arquitectónicos, excavaciones y un análisis tecno-tipológico de conjuntos líticos. Por un lado, se lograron identificar contextos arqueológicos que son el resultado de comportamientos y acciones sociales específicas vinculadas con la logística en torno al aprovisionamiento lítico. Por otro lado, se documentó una riqueza artefactual que da cuenta de modos de hacer particulares y persistentes en el tiempo, lo que aporta conocimientos sobre los saberes-prácticos de las personas. Finalmente, se pudo documentar el valor patrimonial que poseen los paisajes de canteras-taller y el riesgo al que se encuentran expuestos, ya que son constantemente afectados por las actividades humanas modernas. Es en este sentido es que se consideró relevante diseñar acciones que posibiliten preservar los contextos arqueológicos y el ambiente natural.
Rancang Bangun Alat Penentu Jarak di Bawah Air Menggunakan Metode USBL (Ultra Short Base Line) dengan Microkontroler Raspberry Pico dan Sensor Piezoelectric
Authors: Santosa Yoyok Nurkarya , Santoso Susilo Budi , Negara Adhi Kusuma , Putra I Wayan Sumardana Eka 
Published: August 2024

Penelitian ini bertujuan untuk mempelajari dan mengembangkan sistem penentu jarak bawah air dengan membuat rancang bangun alat penentu jarak di bawah air menggunakan metode USBL ( Ultra Short Base Line ) dengan Microkontroler Raspberry Pico dan sensor Piezoelectric. Manfaat penelitian diharapkan dapat memberikan dasar pemahaman dan mengimplementasikan penguasaan teknologi akustik penentu jarak bawah air dalam rangka mencapai kemandirian teknologi, serta dapat memberikan solusi dan mempermudah dalam mengetahui jarak objek dibawah air. Penelitian ini telah menghasilkan sebuah rancang bangun alat penentu jarak di bawah air menggunakan metode USBL (Ultra Short Base Line) dengan Microkontroler Raspberry Pico dan sensor piezoelectric. Rancang bangun alat ini mampu bekerja sesuai prinsip dari USBL (Ultra Short Base Line). Rancang Bangun Alat Penentu Jarak Di Bawah Air Menggunakan Metode USBL (Ultra Short Base Line) Dengan Microkontroler Raspberry Pico Dan Sensor Piezoelectric dapat dikembangkan lebih lanjut dari penentu jarak menjadi penentuan posisi.