bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Dietary Modifications and Physical Activity on Cancer Prevention and Treatment
Authors: Ogunlakin Akingbolabo , Ihiasota Princewill , Ojo Oluwafemi , Ogunlakin Mathew , Ogunlakin Oluwaseun , Olujinmi Faith , Olagookun Favour , Ogunlakin Bowale , Adeyeye Sophie 
Published: June 2024

To prevent and treat cancer, this review aims to assess the goals, mechanisms, and advantages of altered diets and
physical exercise. A comprehensive examination of scholarly publications from various databases, including Springer,
Scopus, Elsevier, Google Scholar, Wiley, Web of Science, PubMed, and Taylor & Francis, was the method utilized to obtain
the data. Additionally, data compilation also made use of PhD and MSctheses. Despite the limited data available, diet
modifications and intervention may prove to be beneficial to cancer patients, including reduced toxicity, improved
chemotherapy efficacy, and curbing long term complications. Diet and physical activity are critical components of human
survival. Imbalanced and improper levels of these factors might disrupt normal homeostasis and impair resilience to
external stresses. This can show in a variety of ways, such as susceptibility to infections, cardio-metabolic disease, or
cancer. Diet modifications coupled with physical activity may influence cancer risk in a variety of ways because some
foods and drinks could predispose the consumers to cancer.

Keywords: Cancer, diet, physical exercise, sedentary lifestyle
KINERJA BANK UMUM SYARIAH BERDASARKAN MAQASHID SYARIAH INDEX
Authors: Wahyuningsih Wahyuningsih , Maryati Maryati , Birton Muhammad Nur Abdullah 
Published: June 2024

This study aims to measure the performance of Sharia Commercial Banks (BUS) using the Maqashid Syariah Index (MSI), and compare the results using the capital structure of BUS. This study applies quantitative and comparative -descriptive methods based on data from the annual financial statements of 12 BUS Indonesia for the 2021-2022. Data analysis was conducted using three MSI indicators (ratios), namely educating individuals, upholding justice, and promoting prosperity, as the basis for evaluation. The results showed that in 2021, there were five BUS that obtained results above 0.1; in order, namely BTPNS, BAS, BMS, BSI, and BCAS. In 2022, there are BUS goals that obtain results above 0.1, respectively, namely BTPNS, BMS, BAS, BCAS, BSI, BNTB, BJBS. Measured by KBMI, BTPNS (KBMI 2) ranked 1st two years in a row; while BSI (KBMI 3) is only ranked 4th (2021), even in 2022 it fell to rank 5 (2022). This means that the capital structure (KBMI) is not positively correlated with MSI's performance.
Peran Zakat Dan Wakaf Sebagai Alternatif Meningkatkan Kesejahteraan Masyarakat
Authors: Risnaningsih Inne 
Published: June 2024

This research aims to eksplained about zakat role and waqf especially money waqf as the alternative to improving social welfare. This research conducted is a descriptive qualitative study with the literature study. Based on research result state that to effect the zakat and waqf toward poored increasing to ower.given but on micro level,because that date limited and zakat and waqf contribution is small relative as more than Nasional economic. It is because still to integrated management zakat and waqf toward economic nasional polic.
Pelaksanaan Akad Wadiah Pada Koperasi Pojok Syariah
Authors: Reviana Assyarif Irma , Risnaningsih Inne , Nurjamil Nurjamil 
Published: June 2024

Wadiah is a type of savings that is purely a depositor/customer, which must be maintained and returned at any time in accordance with mutual agreement or in accordance with the depositor/customer wishes. This wadiah contract savings is adjusted to the Presfective of DSN MUI Fatwa No.02 / DSN-MUI / IV / 2000 concerning wadiah savings. Therefore, this study aims to determine the application of the wadiah contract, the conformity of the DSN MUI Fatwa Presfective No.02 / DSN-MUI / IV / 2000, and find out the efforts made by the Sharia Pojok Cooperative to comply with the Fatwa Prefectives of the National Sharia Council of the Indonesian Ulema Council. The research method used is to use a qualitative descriptive approach. Data collection obtained through observations to the Sharia Pojok Cooperative an also interviews with informants and literature studies to be able to describe the implementation of the wadiah contract. The results of this study are known that the implementation of the wadiah agreement in the Sharia Pojok Cooperative has one discrepancy with the Prefectives of the Fatwa of the National Sharia Council of the Indonesian Ulema Council No.02 / DSN-MUI / IV / 2000 concerning Savings, namely the Sharia Pojok Cooperative hinting at the bonus at the beginning of the contract of 4%.
ENTREVISTA COM DENISE STOKLOS
Authors: Ledesma Fabio , Eleotério Soares Barroso Aurea 
Published: June 2024

Este manuscrito apresenta sucintamente a trajetória de Denise Stoklos, brasileira, coreógrafa, atriz, diretora, escritora. Autora do método teatral “ Teatro Essencial” que visa ter em cena o mínimo possível de efeitos e o máximo de teatralidade no palco. Lecionou esse método na Universidade de Nova York e o encenou em mais de trinta países, em diversos idiomas. Recebeu dezenas de prêmios no Brasil e fora do nosso país. Continua criando, mostrando a todos a singularidade de seu potencial artístico.
Quantifying the effects of five rehabilitation training methods on the ability of elderly men to control bowel movements: a finite element analysis study
Authors: Wang Rui , Liu Guangtian , Jing Liwei , Zhang Jing , Ye Yan , Zhu Haoran 
Published: June 2024

PurposeThe study aims to develop a finite element model of the pelvic floor and thighs of elderly men to quantitatively assess the impact of different pelvic floor muscle trainings and the urinary and defecation control ability.MethodsA finite element model of the pelvic floor and thighs of elderly men was constructed based on MRI and CT. Material properties of pelvic floor tissues were assigned through literature review, and the relative changes in waistline, retrovesical angle (RVA) and anorectad angulation (ARA) to quantitatively verify the effectiveness of the model. By changing the material properties of muscles, the study analyzed the muscle strengthening or impairment effects of the five types of rehabilitation training for four types of urination and defecation dysfunction. The changes in four outcome indicators, including the retrovesical angle, anorectad angulation, stress, and strain, were compared.ResultsThis study indicates that ARA and RVA approached their normal ranges as material properties changed, indicating an enhancement in the urinary and defecation control ability, particularly through targeted exercises for the levator ani muscle, external anal sphincter, and pelvic floor muscles. This study also emphasizes the effectiveness of personalized rehabilitation programs including biofeedback, exercise training, electrical stimulation, magnetic stimulation, and vibration training and advocates for providing optimized rehabilitation training methods for elderly patients.DiscussionBased on the results of computational biomechanics, this study provides foundational scientific insights and practical recommendations for rehabilitation training of the elderly’s urinary and defecation control ability, thereby improving their quality of life. In addition, this study also provides new perspectives and potential applications of finite element analysis in elderly men, particularly in evaluating and designing targeted rehabilitation training.
Risk factors for thrombotic events in systemic lupus erythematosus patients with antiphospholipid antibodies: insights from morphometric measurements of carotid arteries
Authors: Yang Qing , Liu Qi , Yin Changqing , Zhang Xiaoyu , Chen Xi , Pylypenko Dmytro , Chen Hao , Shu Qiang , Yu Dexin 
Published: June 2024

ObjectiveTo identify the correlation between thrombosis and atherosclerosis in systemic lupus erythematosus (SLE) patients with antiphospholipid antibodies (aPLs) (SLE/aPLs) through high-resolution magnetic resonance imaging (HR-MRI) of the carotid artery.MethodsA single-center, cross-sectional study was conducted. We collected consecutive patients with SLE/aPLs and healthy controls who underwent carotid HR-MRI examinations. The morphometric characteristics of the common carotid artery (CCA), internal carotid artery (ICA), external carotid artery (ECA), and carotid bulb (Sinus) were measured, and the differences in morphometric parameters between different groups were analyzed.ResultsA total of 144 carotid arteries were analyzed. Compared with the control group, the wall area, wall thickness (WT and WTmax), and normalized wall index of CCA, ICA, ECA, and Sinus were increased in patients with SLE/aPLs, and the total vascular area (TVA) of CCA, ICA, and Sinus, and the bifurcation angle (BIFA) of ICA-ECA were also increased. A negative lupus anticoagulant (LAC) (with or without positive anticardiolipin antibody (aCL) or anti-β2glycoprotein antibody (aβ2GPI)) contributed to illustrating lower increased TVA and thickened vessel walls of CCA and ICA in SLE/aPLs patients without thrombotic events. Logistic regression analysis showed that WTmaxSinus and WTmaxGlobal were independent risk factors for thrombotic events in SLE/aPLs patients. The receiver operator characteristic curve showed that the cut-off value of WTmaxSinus was 2.855 mm, and WTmaxGlobal was 3.370 mm.ConclusionHR-MRI ensures the complete and accurate measurement of carotid morphometric parameters. Compared with the control group, the carotid artery in patients with SLE/aPLs is mainly characterized by diffusely thickened vessel walls, and the patients with thrombotic events showed additional higher vascular area of CCA and ICA, and BIFA of ICA-ECA without significant change in lumen area. The carotid arteries of SLE/aPLs patients with thrombotic events exhibited significant vessel wall thickening in all segments except ECA compared to those without thrombotic events. LAC-negative and non-thrombotic events distinguish relatively early atherosclerosis in the carotid arteries in patients with SLE/aPLs. Patients with SLE/aPLs that possess circumscribed thickened carotid vessel walls (&gt;3.370 mm), particularly thickened at the Sinus (&gt;2.855 mm), may require management strategies for the risk of thrombotic events.
Same-day discharge after percutaneous closure of persistent foramen ovale using intracardiac echocardiography and the Gore Septal Occluder
Authors: Steiner Kristoffer , Sjöberg Gunnar , Damlin Anna , Settergren Magnus , Verouhis Dinos 
Published: June 2024

AimPeriprocedural and postinterventional care of patients undergoing closure of patent foramen ovale (PFO) varies significantly across care providers. Same-day discharge (SDD) after transcatheter interventions is an evolving concept. This study aimed to assess the same-day discharge rate and incidence of complications in patients undergoing PFO closure with intracardiac echocardiography (ICE) using the Gore®Cardioform Septal Occluder (GSO) device. The secondary aim was to analyse the efficacy of femoral vein closure with Perclose ProGlide.MethodsPatients who underwent PFO closure with the GSO device at a university hospital in Stockholm, Sweden, were retrospectively included between March 1, 2017, and June 30, 2020, all with cryptogenic stroke as the indication for the procedure. All patients underwent PFO closure with conscious sedation and local anaesthesia. The indication for all patients was a cryptogenic stroke. Periprocedural imaging was performed using ICE and fluoroscopy in all patients. Patient characteristics and periprocedural data were collected from patient charts. Patients were kept on bed rest for 4–6 h post-intervention. Transthoracic echocardiography and clinical examination, including groin status, were performed before discharge. No clinical routine follow-up was performed the day following the intervention. Clinical follow-up was done by phone call two weeks after the procedure, and echocardiographic follow-up was done after 12 months. Data were analysed using linear and logistic regression models.ResultsIn total, 262 patients were included, of which 246 (94%) had SDD. 166 patients (63%) received the ProGlide™ system for femoral vein access closure. Post-procedural arrhythmias occurred in 17 (6%) patients, and vascular complications in 9 patients (3%). The overall closure rate at follow-up was 98.5%. 25 out of 264 patients (9.5%) had to be readmitted within the first eight weeks after PFO closure, 16 due to atrial fibrillation warranting electric cardioversion, one due to an arteriovenous fistula that was operated, four due to chest pain/pain at the access site, and four patients developed fever. There was no difference in SDD among patients who received ProGlide™ vs. patients who did not receive ProGlide™.ConclusionSDD appears safe after transcatheter PFO closure with the GSO device with high procedural success rates. Low rates of complications and readmissions make the intervention suitable for this patient-friendly and cost-effective concept.
MedT5SQL: a transformers-based large language model for text-to-SQL conversion in the healthcare domain
Authors: Marshan Alaa , Almutairi Anwar Nais , Ioannou Athina , Bell David , Monaghan Asmat , Arzoky Mahir 
Published: June 2024

IntroductionIn response to the increasing prevalence of electronic medical records (EMRs) stored in databases, healthcare staff are encountering difficulties retrieving these records due to their limited technical expertise in database operations. As these records are crucial for delivering appropriate medical care, there is a need for an accessible method for healthcare staff to access EMRs.MethodsTo address this, natural language processing (NLP) for Text-to-SQL has emerged as a solution, enabling non-technical users to generate SQL queries using natural language text. This research assesses existing work on Text-to-SQL conversion and proposes the MedT5SQL model specifically designed for EMR retrieval. The proposed model utilizes the Text-to-Text Transfer Transformer (T5) model, a Large Language Model (LLM) commonly used in various text-based NLP tasks. The model is fine-tuned on the MIMICSQL dataset, the first Text-to-SQL dataset for the healthcare domain. Performance evaluation involves benchmarking the MedT5SQL model on two optimizers, varying numbers of training epochs, and using two datasets, MIMICSQL and WikiSQL.ResultsFor MIMICSQL dataset, the model demonstrates considerable effectiveness in generating question-SQL pairs achieving accuracy of 80.63%, 98.937%, and 90% for exact match accuracy matrix, approximate string-matching, and manual evaluation, respectively. When testing the performance of the model on WikiSQL dataset, the model demonstrates efficiency in generating SQL queries, with an accuracy of 44.2% on WikiSQL and 94.26% for approximate string-matching.DiscussionResults indicate improved performance with increased training epochs. This work highlights the potential of fine-tuned T5 model to convert medical-related questions written in natural language to Structured Query Language (SQL) in healthcare domain, providing a foundation for future research in this area.
Daily standing time, dietary fiber, and intake of unsaturated fatty acids are beneficially associated with hepatic insulin sensitivity in adults with metabolic syndrome
Authors: Laine Saara , Sjöros Tanja , Garthwaite Taru , Honka Miikka-Juhani , Löyttyniemi Eliisa , Eskola Olli , Saarenhovi Maria , Kallio Petri , Koivumäki Mikko , Vähä-Ypyä Henri , Sievänen Harri , Vasankari Tommi , Hirvonen Jussi , Laitinen Kirsi , Houttu Noora , Kalliokoski Kari , Saunavaara Virva , Knuuti Juhani , Heinonen Ilkka H.A. 
Published: June 2024

BackgroundObesity is associated with impaired glucose metabolism and hepatic insulin resistance. The aim was to investigate the associations of hepatic glucose uptake (HGU) and endogenous glucose production (EGP) to sedentary behavior (SB), physical activity (PA), cardiorespiratory fitness, dietary factors, and metabolic risk markers.MethodsForty-four adults with metabolic syndrome (mean age 58 [SD 7] years, BMI ranging from 25–40kg/; 25 females) were included. HGU was measured by positron emission tomography during the hyperinsulinemic-euglycemic clamp. EGP was calculated by subtracting the glucose infusion rate during clamp from the glucose rate of disappearance. SB and PA were measured with hip-worn accelerometers (26 [SD3] days). Fitness was assessed by maximal bicycle ergometry with respiratory gas measurements and dietary intake of nutrients by 4-day food diaries.ResultsHGU was not associated with fitness or any of the SB or PA measures. When adjusted for sex, age, and body fat-%, HGU was associated with whole-body insulin sensitivity (β=0.58), water-insoluble dietary fiber (β=0.29), energy percent (E%) of carbohydrates (β=-0.32), saccharose (β=-0.32), mono- and polyunsaturated fatty acids (β=0.35, β=0.41, respectively). EGP was associated with whole-body insulin sensitivity (β=-0.53), and low-density lipoprotein cholesterol [β=-0.31], and when further adjusted for accelerometry wear time, EGP was associated with standing [β=-0.43]. (p-value for all&lt; 0.05).ConclusionsStanding more, consuming a diet rich in fiber and unsaturated fatty acids, and a lower intake of carbohydrates, especially sugar, associate beneficially with hepatic insulin sensitivity. Habitual SB, PA, or fitness may not be the primary modulators of HGU and EGP. However, these associations need to be confirmed with intervention studies.
Emerging chemotherapy-based treatments in anaplastic thyroid cancer: an updated analysis of prospective studies
Authors: Wang Bi-Cheng , Lin Guo-He , Kuang Bo-Hua , Cao Ru-Bo 
Published: June 2024

BackgroundFor patients with anaplastic thyroid cancer (ATC) without mutational driver genes, chemotherapy is suggested to be the first-line treatment option. However, the benefits of chemotherapy in treating ATC are limited. In this analysis, we collected the prospective data reported since 2010 to analyze the emerging chemotherapy-based treatments in ATC comprehensively.MethodsFor this updated analysis, we searched PubMed (MEDLINE), Web of Science, Embase, and Cochrane CENTRAL databases from 1 January 2010 to 7 February 2024 for prospective clinical studies that contained chemotherapy-based treatments. This analysis was done to pool overall survival (OS), progression-free survival (PFS), objective response rates (ORRs), disease control rates (DCRs), and grade 3 or worse treatment-related adverse events (TRAEs).ResultsSix prospective clinical trials with 232 patients were included. Chemotherapy was commonly combined with targeted therapy or radiotherapy. The pooled median OS was 6.0 months (95% CI 4.1–9.7), and the median PFS was 3.2 months (95% CI 1.9–6.0) in patients with ATC who received chemotherapy-based strategies. The integrated ORR and DCR were 21% (95% CI 15%–27%) and 64% (95% CI 55%–72%), respectively. Regarding the grade 3 or worse TRAE, the pooled incidence was 68% (95% CI 47%–86%).ConclusionAlthough the emerging chemotherapy-based treatments showed antitumor activity in patients with ATC, these strategies failed to prolong the survival time substantially. More practical, safe, and novel therapeutic regimens for patients with ATC warrant further investigations.
A meta-analysis of the effects of transnasal high-flow oxygen therapy in gastrointestinal endoscopy
Authors: Wei Chen , Ma Shaoyong , Jiang Lili , Wang Jingwen , Yuan Liping , Wang Yingying 
Published: June 2024

PurposeThis study aimed to systematically evaluate the clinical effects of using transnasal high-flow nasal cannula (HFNC) and conventional oxygen therapy (COT) in patients undergoing gastrointestinal endoscopy.MethodsA comprehensive literature search was conducted from 2004 to April 2024 to collect relevant studies on the application of HFNC in patients undergoing gastrointestinal endoscopy. Multiple Chinese and English databases, including China National Knowledge Infrastructure (CNKI), Wanfang Data, Web of Science, PubMed, and Cochrane Library, were searched systematically for randomized controlled trials (RCTs). Two researchers independently screened the literature, extracted data, and assessed the risk of bias in the included studies. RevMan 5.4 software was utilized for conducting the network meta-analysis.ResultsA total of 12 RCTs involving 3,726 patients were included. Meta-analysis results showed that HFNC reduced the incidence of hypoxemia and improved the minimum oxygen saturation (SpO2) compared with COT [odds ratio (OR) = 0.39, 95% confidence interval (CI): 0.29–0.53], [mean difference (MD) = 4.07, 95% CI: 3.14–5.01], and the difference was statistically significant. However, the baseline SpO2 levels and incidence of hypercapnia were not statistically significantly different between the HFNC and COT groups [MD = −0.21, 95% CI: −0.49–0.07]; [OR = 1.43, 95% CI: 0.95–2.15]. In terms of procedure time, the difference between HFNC and COT was not statistically significant, and subgroup analyses were performed for the different types of studies, with standard deviation in the gastroscopy group (MD = 0.09, 95% CI: −0.07–0.24) and the endoscopic retrograde cholangiopancreatography group (MD = 0.36, 95% CI: −0.50–1.23). The results demonstrated a significant reduction in the adoption of airway interventions in the HFNC group compared to the COT group (OR = 0.16, 95% CI: 0.05–0.53), with a statistically significant difference; this result was consistent with those of the included studies.ConclusionThe application of HFNC improves the incidence of hypoxemia, enhances oxygenation, and reduces airway interventions during gastrointestinal endoscopy. However, HFNC does not significantly affect baseline SpO2, hypercapnia, or procedure time. The limitations of this study must be acknowledged, and further high-quality studies should be conducted to validate these findings.