bluuebunny/crossref_metadata_2025_split huggingface dataset:
CEO Compensation Risk and Timely Loss Recognition
Authors: Brockman Paul , Ma Tao , Ye Jianfang 
Published: November 2014

AbstractPrior studies demonstrate that high CEO compensation risk encourages managers to engage in risk‐seeking behavior, thus intensifying agency conflicts between creditors and borrowers. We argue and document that accounting conservatism plays an important role in mitigating debt holder and shareholder conflicts over asset substitution arising from high CEO compensation risk. Our empirical results show that firms with high CEO compensation risk tend to use more timely loss recognition and this positive relationship is more pronounced for firms with high leverage. Additional results show that the positive relationship between CEO compensation risk and borrowing costs is reduced for firms using timely loss recognition, suggesting that creditors perceive timely loss recognition as a risk‐reducing mechanism. Using the passage of FAS 123R as a quasi‐natural experiment on managerial compensation risk, we find a significant reduction in the use of timely loss recognition for firms experiencing a decrease in CEO compensation risk after the passage of FAS 123R. Lastly, we show that timely loss recognition is positively associated only with the compensation risk of the firm's primary decision maker (i.e., its CEO) and not with the compensation risk of subordinates.
The plastic fly: the effect of sustained fluctuations in adult food supply on life‐history traits
Authors: van den Heuvel J. , Zandveld J. , Mulder M. , Brakefield P. M. , Kirkwood T. B. L. , Shanley D. P. , Zwaan B. J. 
Published: November 2014

AbstractMany adult traits in Drosophila melanogaster show phenotypic plasticity, and the effects of diet on traits such as lifespan and reproduction are well explored. Although plasticity in response to food is still present in older flies, it is unknown how sustained environmental variation affects life‐history traits. Here, we explore how such life‐long fluctuations of food supply affect weight and survival in groups of flies and affect weight, survival and reproduction in individual flies. In both experiments, we kept adults on constant high or low food and compared these to flies that experienced fluctuations of food either once or twice a week. For these ‘yoyo’ groups, the initial food level and the duration of the dietary variation differed during adulthood, creating four ‘yoyo’ fly groups. In groups of flies, survival and weight were affected by adult food. However, for individuals, survival and reproduction, but not weight, were affected by adult food, indicating that single and group housing of female flies affects life‐history trajectories. Remarkably, both the manner and extent to which life‐history traits varied in relation to food depended on whether flies initially experienced high or low food after eclosion. We therefore conclude that the expression of life‐history traits in adult life is affected not only by adult plasticity, but also by early adult life experiences. This is an important but often overlooked factor in studies of life‐history evolution and may explain variation in life‐history experiments.
How Does Household Portfolio Diversification Vary with Financial Literacy and Financial Advice?
Authors: GAUDECKER HANS‐MARTIN VON 
Published: November 2014

ABSTRACTHousehold investment mistakes are an important concern for researchers and policymakers alike. Portfolio underdiversification ranks among those mistakes that are potentially most costly. However, its roots and empirical importance are poorly understood. I estimate quantitatively meaningful diversification statistics and investigate their relationship with key variables. Nearly all households that score high on financial literacy or rely on professionals or private contacts for advice achieve reasonable investment outcomes. Compared to these groups, households with below‐median financial literacy that trust their own decision‐making capabilities lose an expected 50 bps on average. All group differences stem from the top of the loss distribution.
Incentivizing Calculated Risk‐Taking: Evidence from an Experiment with Commercial Bank Loan Officers
Authors: COLE SHAWN , KANZ MARTIN , KLAPPER LEORA 
Published: November 2014

ABSTRACTWe conduct an experiment with commercial bank loan officers to test how performance compensation affects risk assessment and lending. High‐powered incentives lead to greater screening effort and more profitable lending decisions. This effect is muted, however, by deferred compensation and limited liability, two standard features of loan officer compensation contracts. We find that career concerns and personality traits affect loan officer behavior, but show that the response to incentives does not vary with traits such as risk‐aversion, optimism, or overconfidence. Finally, we present evidence that incentives distort the assessment of credit risk, even among professionals with many years of experience.
The Authoritarian Personality in Emerging Adulthood: Longitudinal Analysis Using Standardized Scales, Observer Ratings, and Content Coding of the Life Story
Authors: Peterson Bill E. , Pratt Michael W. , Olsen Janelle R. , Alisat Susan 
Published: November 2014

AbstractThree different methods (a standardized scale, an observer‐based Q‐sort, and content coding of narratives) were used to study the continuity of authoritarianism longitudinally in emerging and young adults. Authoritarianism was assessed in a Canadian sample (N = 92) of men and women at ages 19 and 32 with Altemeyer's (1996) Right‐Wing Authoritarianism (RWA) Scale. In addition, components of the authoritarian personality were assessed at age 26 through Q‐sort observer methods (Block, 2008) and at age 32 through content coding of life stories. Age 19 authoritarianism predicted the Q‐sort and life story measures of authoritarianism. Two hierarchical regression analyses showed that the Q‐sort and life story measures of authoritarianism also predicted the RWA scale at age 32 beyond educational level and parental status, and even after the inclusion of age 19 RWA. Differences and similarities in the pattern of correlates for the Q‐sort and life story measures are discussed, including the overall lack of results for authoritarian aggression. Content in narratives may be the result of emerging adult authoritarianism and may serve to maintain levels of authoritarianism in young adulthood.
Interplant signalling through hyphal networks
Authors: Johnson David , Gilbert Lucy 
Published: November 2014

SummaryMycorrhizal fungi can form common mycelial networks (CMNs) that interconnect plants. Here, we provide an insight into recent findings demonstrating that CMNs can be conduits for interplant signalling, influencing defence against insect herbivores and foliar necrotrophic fungi. A likely mechanism is direct transfer of signalling molecules within hyphae. However, electrical signals, which can be induced by wounding, may also enable signalling over relatively long distances, because the biophysical constraints imposed by liquid transport in hyphae and interaction with soil are relieved. We do not yet understand the ecological, evolutionary and agronomic implications of interplant signalling via CMNs. Identifying the mechanism of interplant signalling will help to address these gaps.

Contents

Summary
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I.
Introduction
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II.
Evidence that CMNs facilitate interplant signalling
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III.
Potential mechanisms of interplant signalling
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IV.
Evolutionary drivers of interplant signalling
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V.
Consequences of interplant signal transfer for ecosystems
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VI.
New questions and how to address them
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Acknowledgements
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References
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Is Small Beautiful? Testing the Direct and Nonlinear Effects of Size on Municipal Performance
Authors: Avellaneda Claudia N. , Gomes Ricardo Corrêa 
Published: November 2014

AbstractAlthough the relationship between managerial capacity and local government performance is well established, research into the direct effect of population size on performance has yielded mixed findings. Using data for 787 municipalities in the Brazilian state of Minas Gerais, this article examines the direct and nonlinear effects (moderating and curvilinear) of population size on municipal performance. Performance is measured in terms of property tax collection and averaged for the 2005–07 mayoral administration. Mayor's age (a proxy for experience) and educational attainment serve as measures of managerial capacity. After controlling for political and economic factors, both municipal size and mayoral capacity are positively correlated with property tax collection. However, population size neither moderates managerial capacity nor relates curvilinearly to municipal performance. These findings challenge the promoters of fragmentation, which has been the trend in transitional and developing economies.
Long‐term follow‐up after bronchoscopic lung volume reduction treatment with coils in patients with severe emphysema
Authors: Hartman Jorine E. , Klooster Karin , Gortzak Kiki , ten Hacken Nick H.T. , Slebos Dirk‐Jan 
Published: November 2014

AbstractBackground and objectiveBronchoscopic lung volume reduction coil (LVR‐coil) treatment has been shown to be safe and clinically effective in patients with severe emphysema in the short term; however, long‐term safety and effectiveness has not been evaluated. The aim of this study was to investigate the long‐term safety and effectiveness of LVR‐coil treatment in patients with severe emphysema.MethodsThirty‐eight patients with severe emphysema (median age is 59 years, forced expiratory volume in 1 s is 27% predicted) who were treated in LVR‐coil clinical trials were invited for a voluntary annual visit. Safety was evaluated by chest X‐ray and recording of adverse events and by efficacy by pulmonary function testing, 6‐min walk distance (6MWD) and questionnaires.ResultsThirty‐five patients visited the hospital 1 year, 27 patients 2 years and 22 patients 3 years following coil placement. No coil migrations were observed on X‐rays. At 1‐year follow‐up, all clinical outcomes significantly improved compared with baseline. At 2 years, residual volume % pred, modified Medical Research Council (mMRC) and the SGRQ score were still significantly improved. At 3 years, a significant improvement in mMRC score remained, with 40% of the patients reaching the 6MWD minimal important difference, and 59% for the St George's Respiratory Questionnaire (SGRQ) minimal important difference.ConclusionsFollow‐up of the patients treated with LVR‐coils in our pilot studies showed that the coil treatment is safe with no late pneumothoraces, coil migrations or unexpected adverse events. Clinical benefit gradually declines over time; at 3 years post‐treatment, around 50% of the patients maintained improvement in 6MWD, SGRQ and mMRC.Clinical trial registrationNCT01220908 and NCT01328899 registered at ClinicalTrials.gov.
Selective Immigration Policies and Wages Inequality
Authors: Edo Anthony , Toubal Farid 
Published: November 2014

AbstractWe quantify the overall impact of immigration on native wages in France from 1990 to 2010. Our short‐run simulations indicate that immigration has decreased native wages by 0.6%. We find on average no impact of immigration on wages in the long run. However, we show that the long‐run effects of immigration on wages are detrimental to high‐skilled native workers and benefits to low‐skilled native workers. Our structural estimation allows us to evaluate the impact of “selective” migration policies. In particular, we find that selective immigration policies toward highly educated workers reduce the wage dispersion of French native workers.
A Collaborative Initiative For the Containment of Antimicrobial Resistance in Mexico
Authors: Zaidi Mussaret B. , Dreser Anahi , Figueroa Inda Marcela 
Published: November 2014

SummaryAntimicrobial resistance exacts worldwide an increasingly significant clinical and economic toll. Despite the international calls for urgent action, antimicrobial use and resistance have been low on the Mexican government's policy agenda. In early 2010, a multidisciplinary group of experts launched a national initiative for containment of antimicrobial resistance that was endorsed by major medical, veterinary and public health institutions. The initiative called for seven priority actions including the creation of an ad hoc intersectoral advisory group, a requirement that human and veterinary antibiotics be dispensed only with prescription, and the establishment of effective surveillance systems. A consensus document was disseminated among key decision‐makers at the ministries of Health and Agriculture and the legislature. The Ministry of Health (MoH) enacted a decree effective as of August 2010, which enforced the regulations that required medical prescriptions for the sale of human antibiotics. While the information disseminated by the MoH did focus on the dangers of self‐medication, it failed to highlight the inherent perils of antibiotic resistance or the consequences of antibiotic use in food‐animals. Following the decree, there was a surge of medical offices controlled by retail pharmacies. In the veterinary sector, voluntary guidelines were developed for good husbandry practices, including antibiotic use in food animals; five antimicrobials for use in food‐animals were banned. No intersectoral advisory group or surveillance systems were established. This study describes a bottom‐top approach in Mexico for the development of a national strategy to improve antibiotic use and contain antimicrobial resistance. Its experiences suggest that, in countries such as Mexico that lack strong regulatory systems and surveillance capacities, a more systemic approach is warranted. Future efforts should begin with early involvement of key stakeholders and informing policy makers, professionals and the population at large about the critical importance of antibiotic resistance.
Weather Forecasting Using GPU-Based Large-Eddy Simulations
Authors: Schalkwijk Jerôme , Jonker Harmen J. J. , Siebesma A. Pier , Van Meijgaard Erik 
Published: November 2014

Abstract
Since the advent of computers midway through the twentieth century, computational resources have increased exponentially. It is likely they will continue to do so, especially when accounting for recent trends in multicore processors. History has shown that such an increase tends to directly lead to weather and climate models that readily exploit the extra resources, improving model quality and resolution. We show that Large-Eddy Simulation (LES) models that utilize modern, accelerated (e.g., by GPU or coprocessor), parallel hardware systems can now provide turbulence-resolving numerical weather forecasts over a region the size of the Netherlands at 100-m resolution. This approach has the potential to speed the development of turbulence-resolving numerical weather prediction models.
Role of MYD88 in lymphoplasmacytic lymphoma diagnosis and pathogenesis
Authors: Rossi Davide 
Published: November 2014

Abstract
Lymphoplasmacytic lymphoma (LPL) is a distinct B-cell lymphoproliferative disorder primarily characterized by bone marrow infiltration of lymphoplasmacytic cells. When LPL produces a serum monoclonal immunoglobulin of the IgM class, it is termed Waldenström macroglobulinemia (WM). The differential diagnosis between LPL and other types of morphologically similar B-cell tumors that may also have plasmacytic differentiation and/or secretion of IgM paraproteins is not always clear-cut based solely on the pathologic and phenotypic features of the tumor. Although the current treatments for LPL/WM are initially effective in inducing responses in most patients, they are not curative and show decreasing efficacy with repeated administrations, ultimately resulting in the selection of a chemoresistant clone. Next-generation sequencing studies have identified somatic mutations of MYD88, a key component of the Toll-like receptor signaling machinery, in ∼90% of LPL/WM. Deregulated MYD88 signaling promoted by mutations sustains tumor cell survival in LPL/WM, demonstrating that they are gain-of-function driver events in this lymphoma. This review discusses the molecular and biological mechanisms underlying MYD88 mutations in LPL/WM, the role of MYD88 mutations as molecular biomarker for the refinement of diagnosis and the improvement classification of LPL/WM, and novel targeted therapeutic strategies for LPL/WM based on the pharmacological manipulation of MYD88 signaling to which this lymphoma is addicted.
Mutations in chronic lymphocytic leukemia and how they affect therapy choice: focus on NOTCH1, SF3B1, and TP53
Authors: Zent Clive S. , Burack W. Richard 
Published: November 2014

Abstract
Chronic lymphocytic leukemia (CLL) is characterized by a relatively small number of recurrent genetic defects. These can be evaluated by clinically available methods such as fluorescent in situ hybridization and targeted sequencing approaches to provide data that can be very helpful in prognostication and planning of treatment. Acquired defects in the p53 pathway, activating mutations of NOTCH1, and dysfunctional mutations of SF3B1 and BIRC3 identify patients with higher risk of progressive disease, poorer responses to conventional chemoimmunotherapy, and shorter survival. Risk stratification using these data can identify patients with aggressive CLL who require careful monitoring and are unlikely to have durable responses to chemoimmunotherapy at disease progression. Patients with defective DNA damage repair mechanisms because of p53 dysfunction should be considered for non-chemotherapy-based regimens including tyrosine kinase inhibitors, BCL2 inhibitors, monoclonal antibodies, and immunological therapies including allogeneic transplantation and chimeric antigen receptor-targeted T cells. Conversely, patients with no high-risk mutations can usually be monitored for a prolonged time and are likely to have durable responses to chemoimmunotherapy at disease progression. New technologies for genetic analysis such as targeted next-generation sequencing have the potential to make these analyses cheaper, faster, and more widely available. Comprehensive genetic analysis of patients both at diagnosis and before treatment for progressive disease could become an integral component of care for CLL.
Treating acute myeloid leukemia in older adults
Authors: Wang Eunice S. 
Published: November 2014

Abstract
Acute myeloid leukemia (AML) is a disease of older adults, with a median age of 67 years at presentation. In the past, only a third of older patients (defined as individuals older than 60-65 years of age) with AML received definitive therapy for their disease due to concerns about their overall fitness and potential treatment-related mortality. However, compelling epidemiological data have shown unequivocally that older AML patients up to 80 years old both tolerate and survive longer after therapy than their untreated counterparts. Current therapeutic options for elderly individuals with AML include intensive chemotherapy with a cytarabine and anthracycline backbone, hypomethylating agents (decitabine and azacitidine), low-dose cytarabine, investigational agents, and supportive care with hydroxyurea and transfusions. Over the last few years, there has been increasing debate regarding the appropriate therapeutic approach to take in older adults given the diversity of the geriatric patient population and heterogeneous AML disease biology. This article discusses how performance status, comorbidities, disease characteristics, quality of life concerns, and long-term treatment goals affect the selection of appropriate therapy for older adults with AML. Risks and benefits of each treatment approach based on the most recent medical literature are discussed. Finally, a treatment algorithm summarizing these data and incorporating geriatric assessment and molecular and cytogenetic markers predictive of therapeutic response is proposed to aid in the clinical decision-making process.
The classical Hodgkin lymphoma tumor microenvironment: macrophages and gene expression-based modeling
Authors: Scott David W. , Steidl Christian 
Published: November 2014

Abstract
Despite the high cure rate in classical Hodgkin lymphoma (CHL), more accurate tailoring of upfront treatment is required to maximize cure while avoiding unnecessary short- and long-term treatment side effects. To this end, the unique tumor microenvironment of CHL has been searched extensively for prognostic biomarkers. Beyond targeted immunohistochemistry (IHC) studies, gene expression profiling (GEP) of diagnostic whole tissue biopsies has allowed a de novo approach to biomarker discovery. Among numerous candidate biomarkers, an association between the number of tumor-associated macrophages in the microenvironment and outcomes after ABVD (doxorubicin + bleomycin + vinblastine + dacarbazine) chemotherapy emerged, and multiple subsequent studies have validated this biological relationship using IHC. These studies have also defined key aspects for macrophage interrogation, including the characteristics of the CD68 and CD163 antibodies, appropriate scoring methodologies, and the identification of specific patient populations in which macrophage IHC may not be prognostic. The GEP studies also led to the development of gene expression-based prognostic models for advanced-stage CHL, with new technologies allowing reliable gene expression quantitation using RNA from routinely produced formalin-fixed paraffin-embedded biopsies. The bridge to predictive biomarkers that can be used reliably to inform upfront treatment selection requires further studies to demonstrate that these biomarkers can identify robustly, at diagnosis, patients at high risk of treatment failure with ABVD and that this risk may be overcome using alternative treatments.
Allogeneic hematopoietic cell transplantation for acute myeloid leukemia in older adults
Authors: Sorror Mohamed L. , Estey Elihu 
Published: November 2014

Abstract
Acute myeloid leukemia (AML) is primarily a disease of the elderly and the numbers of these patients are increasing. Patients ≥60 years of age continue to have poor prognosis. Preliminary results suggest benefit from reduced-intensity allogeneic hematopoietic cell transplantation (HCT) in selected patients 60-80 years of age. However, although patients in this age range comprise >50% of those with AML, they currently constitute only 17% of those offered HCT. In the absence of prospective randomized studies comparing HCT and chemotherapy, the decision to recommend HCT rests on retrospective analyses of the risks of relapse and nonrelapse mortality after each approach. There is strong evidence that pre-HCT comorbidities can predict HCT-related morbidity and mortality. Age alone does not appear predictive and, particularly if the risk of relapse with chemotherapy is high, should not be the sole basis for deciding against HCT. Use of geriatric assessment tools, inflammatory biomarkers, and genetic polymorphism data may further aid in predicting nonrelapse mortality after HCT. Disease status and pretreatment cytogenetics with FLT3-TID, NPM-1, and CEBP-α status are the main factors predicting relapse and these are likely to be supplemented by incorporation of other molecular markers and the level of minimal residual disease after chemotherapy. HLA-matched related and unrelated donor grafts seem preferable to those from other donor sources. Donor age is of no clear significance. Models combining comorbidities with AML risk factors are useful in risk assessment before HCT. In this chapter, we integrated information on AML-specific, HCT-specific, and patient-specific risk factors into a risk-adapted approach to guide decisions about HCT versus no HCT.