bluuebunny/crossref_metadata_2025_split huggingface dataset:
Residential proximity to industrial combustion facilities and risk of non-Hodgkin lymphoma: a case–control study
Authors: Pronk Anjoeka , Nuckols John R , De Roos Anneclaire J , Airola Matthew , Colt Joanne S , Cerhan James R , Morton Lindsay , Cozen Wendy , Severson Richard , Blair Aaron , Cleverly David , Ward Mary H 
Published: February 2013

Abstract
Background
Residence near municipal solid waste incinerators, a major historical source of dioxin emissions, has been associated with increased risk of non-Hodgkin lymphoma (NHL) in European studies. The aim of our study was to evaluate residence near industrial combustion facilities and estimates of dioxin emissions in relation to NHL risk in the United States.

Methods
We conducted a population-based case–control study of NHL (1998–2000) in four National Cancer Institute-Surveillance Epidemiology and End Results centers (Detroit, Iowa, Los Angeles, Seattle). Residential histories 15 years before diagnosis (similar date for controls) were linked to an Environmental Protection Agency database of dioxin-emitting facilities for 969 cases and 749 controls. We evaluated proximity (3 and 5 km) to 10 facility types that accounted for >85% of U.S. emissions and a distance-weighted average emission index (AEI [ng toxic equivalency quotient (TEQ)/year]).

Results
Proximity to any dioxin-emitting facility was not associated with NHL risk (3 km OR = 1.0, 95% CI 0.8-1.3). Risk was elevated for residence near cement kilns (5 km OR = 1.7, 95% CI 0.8-3.3; 3 km OR = 3.8, 95% CI 1.1-14.0) and reduced for residence near municipal solid waste incinerators (5 km OR = 0.5, 95% CI 0.3-0.9; 3 km OR = 0.3, 95% CI 0.1-1.4). The AEI was not associated with risk of NHL overall. Risk for marginal zone lymphoma was increased for the highest versus lowest quartile (5 km OR = 2.6, 95% CI 1.0-6.8; 3 km OR = 3.0, 95% CI 1.1-8.3).

Conclusions
Overall, we found no association with residential exposure to dioxins and NHL risk. However, findings for high emissions and marginal zone lymphoma and for specific facility types and all NHL provide some evidence of an association and deserve future study.
RETRACTED ARTICLE: Single-wall carbon nanohorns inhibited activation of microglia induced by lipopolysaccharide through blocking of Sirt3
Authors: Li Lihong , Zhang Jinqian , Yang Yang , Wang Qiang , Gao Li , Yang Yanlong , Chang Tao , Zhang Xingye , Xiang Guoan , Cao Yongmei , Shi Zujin , Zhao Ming , Gao Guodong 
Published: February 2013

AbstractSingle-wall carbon nanohorns (SWNHs) have been demonstrated to accumulate in cytotoxic levels within organs of various animal models and cell types, which emerge as a wide range of promising biomedical imaging. Septic encephalopathy (SE) is an early sign of sepsis and associated with an increased rate of morbidity and mortality. Microglia activation plays an important role in neuroinflammation, which contributes to neuronal damage. Inhibition of microglia activation may have therapeutic benefits, which can alleviate the progression of neurodegeneration. Therefore, we investigated the functional changes of mice microglia cell lines pre-treated with or without lipopolysaccharide (LPS) induced by SWNHs. To address this question, the research about direct role of SWNHs on the growth, proliferation, and apoptosis of microglia cell lines in mice (N9 and BV2) pre-treated with or without LPS had been performed. Our results indicate that the particle diameter of SWNHs in water is between 342 to 712 nm. The images in scanning electron microscope showed that SWNHs on polystyrene surface are individual particles. LPS induced activation of mice microglia, promoted its growth and proliferation, and inhibited its apoptosis. SWNHs inhibited proliferation, delayed mitotic entry, and promoted apoptosis of mice microglia cells. The effects followed gradually increasing cultured time and concentrations of SWNHs, especially in cells pre-treated with LPS. SWNHs induced a significantly increase in G1 phase and inhibition of S phase of mice microglia cells in a dose-manner dependent of SWNHs, especially in cells pre-treated with LPS. The transmission electron microscope images showed that individual spherical SWNH particles smaller than 100 nm in diameters were localized inside lysosomes of mice microglia cells. SWNHs inhibited mitotic entry, growth and proliferation of mice microglia cells, and promoted its apoptosis, especially in cells pre-treated with LPS. SWNHs inhibited expression of Sirt3 and energy metabolism related with Sirt3 in mice microglia cells in a dose-dependent manner, especially in cells pre-treated with LPS. The role of SWNHs on mice microglia was implicating Sirt3 and energy metabolism associated with it.
Prevalence of diabetic nephropathy complicating non-diabetic renal disease among Chinese patients with type 2 diabetes mellitus
Authors: Zhuo Li , Zou Guming , Li Wenge , Lu Jianhua , Ren Wenwen 
Published: February 2013

Abstract

Background
The incidence of diabetes mellitus (DM) and diabetic nephropathy (DN) have risen rapidly in the past few decades and have become an economic burden to the healthcare system in China. DN is a major complication of DM and is a leading cause of end-stage renal disease (ESRD). The occurrence of non-diabetic renal disease (NDRD) in diabetic patients has been increasingly recognized in recent years. It is generally believed that it is difficult to reverse DN, whereas some cases of NDRD are readily treatable and remittable. However, DN is known to co-exist with NDRD in a poorly defined population of patients with type 2 diabetes mellitus (T2DM). This study estimated the prevalence of co-existing DN and NDRD in Chinese patients.

Methods
Data were retrospectively analyzed from 244 patients with T2DM who had undergone a renal biopsy between January 2003 and December 2011 at the Nephrology Department, China-Japan Friendship Hospital, China. Male patients numbered 151 (61.9%) of the study population. The biopsies were performed because urinary abnormalities or renal function were atypical of a diagnosis of DN. Biopsy samples were examined using light, immunofluorescence (IF) and electron microscopy (EM). Clinical parameters were recorded for each patient at the time of biopsy.

Results
Nineteen of 244 diabetic patients (7.8%) had co-existing DN and NDRD. These patients showed clinical features and pathologic characteristics of DN, including a high prevalence of diabetic retinopathy (89.5%), a long duration of diabetes, increased thickness of the glomerular basement membrane (GBM) and mesangial expansion. However, they also presented with clinical findings which were inconsistent with DN, such as hematuria, rapidly progressive renal failure and marked proteinuria. Immunoglobulin A (IgA) nephropathy was apparent in 10 out of the 19 patients (52.6%), tubulointerstitial lesions were found in four patients (21.1%), membrano-proliferative glomerulonephritis (MPGN) in three patients (15.8%) and membranous nephropathy (MN) in two patients (10.5%).

Conclusion
Retrospective analysis of biopsy data suggests that approximately 8% of Chinese patients with T2DM may have co-existing DN and NDRD. The most common histological diagnosis in our small series was IgA nephropathy.
Fifteen years of GH replacement improves body composition and cardiovascular risk factors
Authors: Elbornsson Mariam , Götherström Galina , Bosæus Ingvar , Bengtsson Bengt-Åke , Johannsson Gudmundur , Svensson Johan 
Published: February 2013

ObjectiveFew studies have determined the effects of more than 5–10 years of GH replacement in adults on body composition and cardiovascular risk factors.Design/patientsIn this prospective, single-center, open-label study, the effects of 15 years of GH replacement on body composition and cardiovascular risk factors were determined in 156 hypopituitary adults (93 men) with adult-onset GH deficiency (GHD). Mean age was 50.5 (range 22–74) years at study start. Body composition was measured using dual-energy X-ray absorptiometry.ResultsThe mean initial GH dose of 0.55 (s.e.m. 0.03) mg/day was gradually lowered to 0.40 (0.01) mg/day after 15 years. The mean serum IGF1 SDS increased from −1.53 (0.10) at baseline to 0.74 (0.13) at study end (P<0.001 vs baseline). Lean soft tissue (LST) increased to 3% above the baseline level at study end (P<0.001). After a 9% decrease during the first year of treatment (P<0.001 vs baseline), body fat (BF) started to increase and had returned to the baseline level after 15 years. Serum levels of total cholesterol and LDL-cholesterol decreased and serum HDL-cholesterol level increased. Fasting plasma glucose increased from 4.4 (0.1) at baseline to 4.8 (0.1) mmol/l at study end (P<0.001). However, blood HbA1c decreased from 5.0 (0.1) to 4.6 (0.1) % (P<0.001).ConclusionsFifteen-year GH replacement in GHD adults induced a transient decrease in BF and sustained improvements of LST and serum lipid profile. Fasting plasma glucose increased whereas blood HbA1c was reduced.
Evaluation of Patient Enrollment in Oncology Phase I Clinical Trials
Authors: Biessen Diane A.J. , Cranendonk Merlijn A. , Schiavon Gaia , Holt Bronno , Wiemer Erik A.C. , Eskens Ferry A.L.M. , Verweij Jaap , Jonge Maja J.A. , Mathijssen Ron H.J. 
Published: February 2013

Abstract

Introduction.
For anticancer drug development, it is crucial that patients participate in early-phase clinical trials. The main aim of this study was to gain insight into the motivations and other variables influencing patients in their decision to participate in phase I oncology trials.

Materials and Methods.
Over a period of 25 months, all patients who were informed about (specific) phase I trials in our cancer center were retrospectively included in this study. Data on providing informed consent and final phase I enrollment were collected.

Results.
In total, 365 patients, with a median age of 59 years and a median World Health Organization performance status score of 1, were evaluated. The majority of patients (71%) were pretreated with systemic therapy, with a median of two lines. After specific study information had been given, 145 patients (40%) declined informed consent, 54% of them mainly because of low expectations regarding treatment benefits and concerns about potential side effects. Patients who had received previous systemic therapy consented more frequently than others. After initial consent, 61 patients (17%) still did not receive study treatment, mostly because of secondary withdrawal of consent or rapid clinical deterioration prior to first dosing.

Discussion.
After specific referral to our hospital for participation in early clinical trials, only 44% of all patients who were informed about a specific phase I trial eventually participated. Reasons for both participation and nonparticipation were diverse. Patient participation rates could be improved by forming an experienced and dedicated study team.
Coronally Advanced Flap Alone or With Connective Tissue Graft in the Treatment of Single Gingival Recession Defects: A Long‐Term Randomized Clinical Trial
Authors: Kuis Davor , Sciran Ivana , Lajnert Vlatka , Snjaric Damir , Prpic Jelena , Pezelj‐Ribaric Sonja , Bosnjak Andrija 
Published: February 2013

Background: Numerous surgical approaches for the treatment of single gingival recession (GR) defects are documented in the literature. The aim of this 5‐year, split mouth–design, randomized clinical trial was to evaluate the effectiveness of coronally advanced flap (CAF) alone versus CAF with connective tissue graft (CAF+CTG) in the treatment of single Miller Class I and II GR defects.Methods: Thirty‐seven patients with 114 bilateral, single Miller Class I and II GR defects were treated with CAF on one side of the mouth and CAF+CTG on the other side. Clinical measurements (GR length [REC], keratinized tissue width [KT], complete root coverage [CRC], and percentage of root coverage [PRC]) were evaluated before surgery and after 6, 12, 24, and 60 months.Results: There was a significant reduction of REC and increase of KT after surgery in both groups. CAF+CTG showed significantly better results for all evaluated clinical parameters in all observed follow‐up periods. Miller Class I defects showed better results in terms of REC, CRC, and PRC, whereas Miller Class II showed better results in KT, both in favor of CAF+CTG. Miller Class I defects showed better results than Miller Class II GR defects regardless of the surgical procedure used.Conclusions: Both surgical procedures were effective in the treatment of single Miller Class I and II GR defects. The CAF+CTG procedure provided better long‐term outcomes (60 months postoperatively) than CAF alone. Long‐term stability of the gingival margin is less predictable for Miller Class II GR defects compared to those of Class I.
Tubulointerstitial Nephropathies in HIV-Infected Patients over the Past 15 Years
Authors: Zaidan Mohamad , Lescure François-Xavier , Brochériou Isabelle , Dettwiler Sarah , Guiard-Schmid Jean-Baptiste , Pacanowski Jérôme , Rondeau Eric , Pialoux Gilles , Girard Pierre-Marie , Ronco Pierre , Plaisier Emmanuelle 
Published: February 2013

Summary

Background and objectives
The therapy and outcome of HIV infection have dramatically changed over the last 15 years, resulting in a change in renal complications. This study analyzed the characteristics of HIV-infected patients and biopsy-proven tubulointerstitial nephropathies to define disease patterns and therapeutic implications.

Design, setting, participants, & measurements
A clinico-pathologic retrospective study of 59 consecutive renal biopsies showing predominant tubular and/or interstitial lesions in HIV-infected patients referred to the nephrology department between 1995 and 2011 was performed. HIV-associated nephropathy and vascular diseases were excluded from the study.

Results
Tubulointerstitial nephropathies accounted for 26.6% of 222 native renal biopsies performed in HIV-infected patients. Two pathologic groups were analyzed, tubulopathy and interstitial nephritis, which represented 49% and 51% of tubulointerstitial nephropathies, respectively. Most patients presented with AKI (76.3%) and high-grade proteinuria (57.7%). Drug-related nephrotoxicity was the leading cause (52.5%). Alternative etiologies included infections (15.2%), dysimmune disorders (8.5%), malignancies (3.4%), and chronic (10.2%) and acute (10.2%) tubulointerstitial nephropathies of undetermined origin. Tubulopathy was strongly associated with antiretroviral drug toxicity (75.9%) and mostly caused by tenofovir (55.2%), which was associated with proximal tubular dysfunction (87.5%), overt Fanconi’s syndrome (37.5%), and nephrogenic diabetes insipidus (12.5%). Interstitial nephritis was associated with a broader spectrum of pathologic lesions and etiologies.

Conclusions
In this series, tubulointerstitial nephropathies accounted for 26.6% of renal diseases in HIV-infected patients. Considering the therapeutic implications of diagnoses of drug toxicity, infection, and dysimmune syndromes, this study underscores the importance of monitoring renal parameters in HIV-infected patients and points to the relevance of kidney biopsy to allow an accurate diagnosis.
(MIS)Translating U.S. Southwest History
Authors: Imhoff Brian 
Published: February 2013

AbstractHistorians of the U.S. Southwest invariably rely on English-language translations of original Spanish documents for their interpretive work. However, a philological approach to the Spanish documents reveals all manner of translator shortcomings, some of which negatively impact the historical record. I document one such instance pertaining to the early history of Texas and argue that the failure to adhere to sound philological practice has produced an inaccurate historical canon. Data are taken from a Spanish expedition diary from the late 17th-century and from unpublished archival sources pertaining to it.
Use of the laboratory tests of soil modulus in modelling pile behaviour
Authors: Dyka Ireneusz 
Published: February 2013

Abstract
This article deals with the question of theoretical description of behaviour of a single pile rested in a layered soil medium. Particular attention is paid to soil modulus which is used in calculation method for pile load-settlement curve. A brief analysis of the results obtained by laboratory tests to assess soil modulus and its nonlinear variability has been presented. The results of tests have been used in triaxial apparatus and resonant column/torsional shear device. There have also been presented the results of load-settlement calculation for a single pile under axial load with implementation of different models of soil modulus degradation. On this basis, possibilities of using particular kinds of laboratory tests in calculation procedure of foundation settlement have been presented as well as further developments of them.
Lychnothamnus Barbatus (Meyen) Leonh. – Rediscovered In Shalow Lake Šventininkai (Lithuania) After 50 Years
Authors: Sinkevičiene Zofija , Urbaitė-Maževič Neringa 
Published: February 2013

Abstract
Lychnothamnus barbatus, which in Lithuania occurs northernmost in Europe, was identified in 4 lakes: Balsys, Mažasis Gulbinu, Vygris and Šventininkai. The aim of the paper was to present the recent vegetation, habitat conditions, abundance and co-occurring plant species in shallow Lake Šventininkai. L. barbatus population was rediscovered after 50 years. It was recorded in 1823 and 1960, but it has not been detected later on during scattered investigations until now. Recent vegetation of Lake Šventininkai is a typical of eutrophic lakes with the domination of Ceratophyllum demersum, Elodea canadensis and rarely - L. barbatus. The submerged communities are represented by 7 associations. L. barbatus was distrib­uted at the depth of 1.1-2.1 m. Nitellopsis obtusa, Chara globularis, Chara contraria were the most common, co-occurring species of I. barbatus. Lake Šventininkai is a unique, very shallow (average depth <3 m) lake with re-established L. barbatus population after its total decline in strongly polluted lake waters following the lake’s self-purification. The presented data are important for the restoration of the status of the protected area and management of this territory.
Modulating Effect of Propolis and Bee Pollen on Chicken Breeding Parameters and Pathomorphology of Liver And Kidneys in the Course of Natural Infection with Salmonella Enteritidis
Authors: Babińska Izabella , Kleczek Katarzyna , Szarek Józef , Makowski Włodzimierz 
Published: February 2013

Abstract
The liver and kidneys of broilers fed during the first two weeks of fattening a fodder containing the addition of 0.025% propolis and/or 0.5% pollen were examined macroscopically and microscopically. Additionally, the effects of these substances on the results of breeding and on pathomorphology of the liver and kidneys in the course of natural, asymptomatic infection with Salmonella Enteritidis were determined. The results demonstrated that propolis has protective effects on the liver of broiler chickens, reducing the intensity of regressive lesions. However, regarding supplementation of the diet with bee pollen, additional research on its effects in animals is needed.
Molecular Detection of Bartonella Sp. in Wild Ruminants and Analysis of its Genetic Diversity on the Basis of 16S–23S Rrna Intergenic Spacer (ITS)
Authors: Adamska Małgorzata 
Published: February 2013

Abstract
The aim of this study was to describe the state of infection of roe deer (Capreolus capreolus) and red deer (Cervus elaphus) by Bartonella sp. in North-Western Poland through PCR detection of Bartonella 16S-23S rRNA ITS region in isolates of animal tissues, and also to describe the genetic diversity of detected Bartonella species based on molecular analysis of ITS. The multiple alignment analysis of ITS sequences was carried out, and homology matrices and phylogenetic trees were constructed. The DNA of Bartonella sp. was detected in tissues of 45.6% (36/79) C. capreolus and of 50% (15/30) C. elaphus. Products of two different sizes were detected: 317 bp, characteristic for B. schoenbuchensis, and 198 bp, characteristic for B. bovis. The obtained results suggest that roe and red deer are potential reservoirs of Bartonella sp. Most of the analysed ITS sequences was not specific for one host species. In constructed phylogenetic trees, sequences obtained from roe and red deer clustered together. These results suggest a lack of host specificity of most detected B. schoenbuchensis and B. bovis intraspecies strains
In-House Validation of Multiplex PCR Method for Detection of Clostridium Botulinum in Food and Feed
Authors: Grenda Tomasz , Kukier Elżbieta , Sieradzki Zbigniew , Goldsztejn Magdalena , Kwiatek Krzysztof 
Published: February 2013

Abstract
The aim of this study was to perform an in-house validation of multiplex PCR method for C. botulinum detection in food and feed samples. The study was carried out on food and feed matrixes artificially contaminated by spores of C. botulinum reference strains. The following characteristic parameters for qualitative detection were estimated: limit of detection expressed as LOD50 according to the Spearman-Kärber formula, specificity, sensitivity, and accuracy according to the PN-EN ISO 16140:2004. The validated method showed high specificity. Specific PCR products were revealed only for DNA obtained from samples contaminated with C. botulinum spores. PCR inhibition was observed, especially during examination of contaminated feed. The calculated LOD50 for feed was nearly 10 times higher than for food. The implemented method enables to obtain test results during 3 d without time- consuming process of isolation and proving the ability of strains to produce botulinum toxins.
Interrelationships between Morphometric, Densitometric, and Mechanical Properties of Mandible in 6-month-old Male Pigs
Authors: Tymczyna Barbara , Bachanek Teresa , Tatara Marcin R. , Krupski Witold , Tymczyna-Sobotka Monika , Łuszczewska-Sierakowska Iwona 
Published: February 2013

Abstract
The aim of the study was to evaluate interrelationships between final body weight, and morphometric, densitometric, and mechanical properties of the mandible in 6-month-old Polish Large White pigs exposed to dexamethasone and nanocalcium. The study was performed on 27 males, castrated on the 28th d after weaning, and reared until the age of 6 months, after which the animals were slaughtered, and the mandible was obtained. The pigs were divided into four experimental groups: animals given per os nanopartical calcium, animals injected with dexamethasone, animals given both nanopartical calcium per os and dexamethasone injections, and animals injected with placebo. After the slaughter, morphological properties of the mandible such as bone weight and length were determined. Using computed tomography technique, volumetric bone mineral density (vBMD) of the cortical bone (Cd), mean volumetric bone mineral density (MvBMD), and total bone volume (Bvol) of whole mandible were measured. Areal bone mineral density (BMD) and bone mineral content were evaluated with the use of dual-energy X-ray absorptiometric method. Using three-point bending test, mechanical parameters such as maximum elastic strength (Wy) and ultimate strength (Wf) of mandible were estimated. Pearson’s correlation coefficient (r) was determined between all the investigated variables. The obtained results showed a significantly positive correlation between body weight and mandible weight, mandible length, Bvol, Cd, BMD, BMC, Wy, and Wf. However, statistically insignificant correlations of MvBMD and body weight, mandible weight, mandible length, and Bvol were observed. Furthermore, Bvol and Cd were not found to be significantly correlated. In conclusion, this study showed numerous positive correlations between final body weight and densitometric, morphometric, and mechanical properties of the mandible. This bone of pigs may be used as an attractive model for further investigation on metabolic response of the skeleton to physiological, nutritional, toxicological, and pharmacological factors influencing bone tissue metabolism.