bluuebunny/crossref_metadata_2025_split huggingface dataset:
International study on antidepressant prescription pattern at 40 major psychiatric institutions and hospitals in Asia: A 10‐year comparison study
Authors: Chee Kok‐Yoon , Tripathi Adarsh , Avasthi Ajit , Chong Mian‐Yoon , Sim Kang , Yang Shu‐Yu , Glover Sandeep , Xiang Yu‐Tao , Si Tian‐Mei , Kanba Shigenobu , He Yan‐Ling , Lee Min‐Soo , Chiu Helen Fung‐Kum , Kuga Hironori , Mahendran Rathi , Udormatn Pichet , Kallivayalil Roy A , Tanra Andi J , Maramis Margarita , Shinfuku Naotaka , Shen Winston W , Tan Chay‐Hoon , Sartorius Norman 
Published: February 2015

AbstractIntroductionResearch in prescription pattern of antidepressants in Asia is lacking. This study aims to compare the antidepressants prescription pattern in Asia in 2003–2004 and 2013.MethodsThe Research in East Asia Psychotropic Prescription Pattern on Antidepressants (REAP‐AD) had worked collaboratively in 2003–2004 (REAP‐AD 2003/2004) and 2013 (REAP‐AD 2013) to study the prescription pattern of antidepressants in Asia. The REAP‐AD 2013 study was conducted in China, Hong Kong, India, Indonesia, Japan, Korea, Malaysia, Singapore, Taiwan, and Thailand using a unified research protocol and questionnaire.ResultsForty psychiatric centers participated in REAP‐AD 2013 and a total of 2,319 patients receive antidepressants were analyzed. In 2013, 39.6% of the antidepressant prescriptions were for diagnoses other thandepressive disorder compared with 38.4% in REAP‐AD 2003/2004. Out of all the antidepressants listed in the Anatomical Therapeutic Chemical Classification index by the World Health Organization Collaborating Center for Drug Statistics Methodology (Oslo), only 38% antidepressants were prescribed in participating centers in 2013 compared with 46% in REAP‐AD 2003/2004. The selective serotonin reuptake inhibitors were the most common antidepressant prescribed in the participating centers, which was similar to the 2003–2004 survey. Prescription of newer generation antidepressants had increased in 2013 survey; on the contrary, prescription of tricyclic antidepressants had reduced.DiscussionThis study has contributed significantly in relation to the changing patterns of antidepressant use in all the participating Asian centers in the last 10 years. The findings are important in shaping optimal antidepressant prescription and future policy making.
Helicobacter pylori second‐line rescue therapy with levofloxacin‐ and bismuth‐containing quadruple therapy, after failure of standard triple or non‐bismuth quadruple treatments
Authors: Gisbert J. P. , Romano M. , Gravina A. G. , Solís‐Muñoz P. , Bermejo F. , Molina‐Infante J. , Castro‐Fernández M. , Ortuño J. , Lucendo A. J. , Herranz M. , Modolell I. , del Castillo F. , Gómez J. , Barrio J. , Velayos B. , Gómez B. , Domínguez J. L. , Miranda A. , Martorano M. , Algaba A. , Pabón M. , Angueira T. , Fernández‐Salazar L. , Federico A. , Marín A. C. , McNicholl A. G. 
Published: February 2015

SummaryBackgroundThe most commonly used second‐line Helicobacter pylori eradication regimens are bismuth‐containing quadruple therapy and levofloxacin‐containing triple therapy, both offering suboptimal results. Combining bismuth and levofloxacin may enhance the efficacy of rescue eradication regimens.AimsTo evaluate the efficacy and tolerability of a second‐line quadruple regimen containing levofloxacin and bismuth in patients whose previous H. pylori eradication treatment failed.MethodsThis was a prospective multicenter study including patients in whom a standard triple therapy (PPI–clarithromycin–amoxicillin) or a non‐bismuth quadruple therapy (PPI–clarithromycin–amoxicillin–metronidazole, either sequential or concomitant) had failed. Esomeprazole (40 mg b.d.), amoxicillin (1 g b.d.), levofloxacin (500 mg o.d.) and bismuth (240 mg b.d.) was prescribed for 14 days. Eradication was confirmed by 13C‐urea breath test. Compliance was determined through questioning and recovery of empty medication envelopes. Incidence of adverse effects was evaluated by questionnaires.Results200 patients were included consecutively (mean age 47 years, 67% women, 13% ulcer). Previous failed therapy included: standard clarithromycin triple therapy (131 patients), sequential (32) and concomitant (37). A total of 96% took all medications correctly. Per‐protocol and intention‐to‐treat eradication rates were 91.1% (95%CI = 87–95%) and 90% (95%CI = 86–94%). Cure rates were similar regardless of previous (failed) treatment or country of origin. Adverse effects were reported in 46% of patients, most commonly nausea (17%) and diarrhoea (16%); 3% were intense but none was serious.ConclusionsFourteen‐day bismuth‐ and levofloxacin‐containing quadruple therapy is an effective (≥90% cure rate), simple and safe second‐line strategy in patients whose previous standard triple or non‐bismuth quadruple (sequential or concomitant) therapies have failed.
Collateral thermal damage to the pancreas by ultrasonic instruments during lymph node dissection in laparoscopic gastrectomy
Authors: Fujita Takeshi , Ohta Manabu , Ozaki Yusuke , Takahashi Yoshiaki , Miyazaki Shinichiro , Harada Takashi , Iino Ichirota , Kikuchi Hirotoshi , Hiramatsu Yoshihiro , Kamiya Kinji , Konno Hiroyuki 
Published: February 2015

AbstractIntroductionLaparoscopic gastrectomy (LG) with D2 or more extended lymphadenectomy for advanced gastric cancer is technically demanding. Collateral thermal damage to the pancreas secondary to energized dissection during lymphadenectomy has been reported. We retrospectively compared the pancreatic damage between LG and open gastrectomy (OG) by measuring the amylase concentration of the drainage fluid and analyzing heat conductance to the pancreas with a porcine model.MethodsWe evaluated the data of 105 consecutive patients with gastric adenocarcinoma who underwent LG or OG with lymph node dissection. Digital thermography was used to evaluate the extent of heat conductance to the pancreas during suprapancreatic lymph node dissection by either an ultrasonically activated device or electric cautery in a porcine model.ResultsThe incidence of clinically relevant pancreatic fistula formation was not statistically significant between the LG and OG groups (3/57 vs 0/48 cases; P = 0.306). However, the median amylase concentrations of the drainage fluid on postoperative days 1 and 3 were 1355.7 and 308.8 IU/L, respectively, in the LG group and 369.0 and 125.8 IU/L, respectively, in the OG group (P < 0.001). In the experimental model, more time was required to cool the surface of the pancreas to < 40°C in the ultrasonically activated device group than in the electric cautery group (10.1 ± 5.2 vs 5.2 ± 3.0 s; P = 0.013).ConclusionsUnavoidable collateral thermal damage to the pancreas associated with electrosurgical devices might exist during LG. Heat conductance must be given more consideration in extended lymph node dissection.
Post‐Injection Delirium/Sedation Syndrome after Olanzapine Long‐Acting Intramuscular Injection – Who is at Risk?
Authors: Łukasik‐Głębocka Magdalena , Sommerfeld Karina , Teżyk Artur , Panieński Paweł , Żaba Czesław , Zielińska‐Psuja Barbara 
Published: February 2015

AbstractThe post‐injection olanzapine delirium/sedation syndrome (PDSS) was observed in a 60‐year‐old Caucasian, schizophrenic, non‐smoker and underweight [body mass index (BMI), 18.2 kg/m2] women after the fourth intramuscular injection of 405 mg olanzapine pamoate. Clinical symptoms of PDSS were similar to those of acute oral olanzapine intoxication. The patient received supportive treatment and recovered fully. High olanzapine concentrations in serum, with maximum level of 698 ng/mL, were confirmed by liquid chromatography with tandem mass spectrometry (LC‐MS/MS). The authors wonder whether a low BMI and advanced age may predispose patients to PDSS occurrence.
Uncovering different parameters influencing florivory in a specialist herbivore
Authors: ABDALSAMEE MOHAMED K. , MÜLLER CAROLINE 
Published: February 2015

1. It has become increasingly recognised that several herbivores switch from folivory (leaf‐feeding) to florivory (flower‐feeding) during larval development. Yet, it remains poorly understood which cues influence this behaviour, whether a switch to florivory is consistently shown on different hosts, and to what extent florivory could be hindered by plant traits.2. Using the sawfly Athalia rosae and two Brassicaceae differing in architecture and surface structure, the cues that influence larval movement to the flowers were investigated. A broad set of behavioural assays was employed and physical and chemical plant traits potentially affecting the larvae were analysed. Furthermore, the consequences of folivory versus florivory on insect performance were studied.3. The larvae preferred flowers over leaves. Consumption of particular flower parts correlated partly with measured plant traits such as glucosinolate distribution. Visual cues were of higher importance than volatile cues. The initial position of newly hatched larvae on plants influenced the probability of the larvae reaching the flowers during development. Trichomes and surface waxes hindered the larvae from moving upwards to the flowers. Larvae developed slower and gained less body mass when feeding on inflorescences of Brassica nigra than when feeding on leaves, in contrast to the patterns observed before on Sinapis alba, where florivory led to an improved performance.4. This study demonstrates that florivory depends on various host plant traits. It reveals new insights into different parameters influencing this multifaceted phenomenon and into the expected impact on the ecology and fitness of both the attacking herbivores and the plants.
Immunohistochemical Expressions of MUC2, MUC5AC, and MUC6 in Normal, Helicobacter pylori Infected and Metaplastic Gastric Mucosa of Children and Adolescents
Authors: Park Ji Sook , Yeom Jung‐Sook , Seo Ji‐Hyun , Lim Jae‐Young , Park Chan‐Hoo , Woo Hyang‐Ok , Youn Hee‐Shang , Jun Jin‐Su , Park Ji‐Hoe , Ko Gyung‐Hyuck , Baik Seung‐Chul , Lee Woo‐Kon , Cho Myung‐Je , Rhee Kwang‐Ho 
Published: February 2015

AbstractObjectivesThe aim of this study was to investigate expression of gastric mucins in children and adolescents and to assess their relations with age and Helicobacter pylori (H. pylori) infection.MethodsGastric biopsies were collected from 259 pediatric and adulthood patients with gastrointestinal symptoms among all of patients undergone gastroduodenoscopy from 1990 to 2004 at Gyeongsang National University hospital and assorted based on H. pylori infection, age, and intestinal metaplasia as follows; H. pylori infection before 5 years of age or not, H. pylori infection between 5 and 9 years of age or not, H. pylori infection between 10 and 14 years of age or not, H. pylori infection between 20 and 29 years of age or not and intestinal metaplasia between 21 and 35 years of age. Total 810 tissue slides from the subjects were examined regarding expressions of Mucin2 (MUC2), Mucin5AC (MUC5AC), and Mucin6 (MUC6) in nine groups using immunohistochemical stains. A semiquantitative approach was used to score the staining extent of tissue slide.ResultsIncreased expressions of MUC2, MUC5AC, and MUC6 were noted in intestinal metaplasia compared with subjects infected with H. pylori between 20 and 29 years. Gastric expressions of MUC5AC were decreased in older than 5 years with H. pylori compared with in older than 5 years without H. pylori (p < .001). Expressions of MUC2 and MUC6 did not change significantly by H. pylori status. Some nuclear expressions of MUC2 and MUC6 were noted in children without intestinal metaplasia.ConclusionsMUC5AC might be affected by chronic H. pylori infection. In addition to biomarkers for intestinal metaplasia or prognostic factors for gastric cancer in adults, MUC2 and MUC6 in children might have an another role, based on ectopic gastric nuclear expressions of MUC2 and MUC6 in children without intestinal metaplasia.
Daily outfit satisfaction: the effects of self and others' evaluation on satisfaction with what I wear today
Authors: Lee Ha Kyung , Choo Ho Jung 
Published: February 2015

AbstractThis study investigated the satisfaction of the outfit which an individual chose to wear for the day by examining how self and others' evaluations influenced the outfit satisfaction and the intention to re‐wear. In addition, moderator variables (body satisfaction and body surveillance) that affected the effect of the evaluative factors upon satisfaction and behavioural intention were also examined. An online‐survey was conducted and the sample size used in the analysis was 349 in total. Using SPSS 18.0 and AMOS 18.0, structural equation modeling analysis and one‐way analysis of variance were implemented for hypothesis testing. The results showed that self‐evaluation as a perception of appropriateness of the outfit for that day and others' positive feedback increases outfit satisfaction. Appropriateness perception also had a significant impact on the intention to re‐wear. However, feedback from others on one's outfit did not have a significant direct effect on behavioural intention. Three‐way ANOVA was performed to verify the impact the feedback from others, body satisfaction, and body surveillance had on the respondent's intention to re‐wear, and a three‐way interaction effect was statistically significant. While individuals with high body satisfaction were likely to be confident about their appearance overall, the feedback from others did not impact their satisfaction. Individuals with low body satisfaction were influenced by others' feedback on their outfit. Individuals with high levels of body surveillance who sensitively monitored others' feedback especially displayed decreased intention to re‐wear when feedback from others on their outfit was negative. This research contributed to the deeper understanding of consumer's clothing behaviour at the post‐purchase stage. Enhanced understanding of lasting satisfaction and benefits pursued throughout the time while using the product would be essential in developing consumer‐centric marketing strategies.
Treatment and Control Groups in a Dynamic Setting
Authors: Rohwer Götz 
Published: February 2015

SummaryThe paper considers a version of the question of how to define treatment and control groups in a dynamic setting where treatments can occur at any time (but only once). The version considered pre‐supposes that treatments as well as outcomes can be conceptualised as events occurring in temporal locations of a discrete time axis. It is proposed to think of effects as being dependent on both the time when and the time since the treatment occurred. The paper develops corresponding definitions of treatment and control groups, and proposes a notion of ‘comprehensive treatment effect’ that takes into account how treatment and control groups are generated. Based on this notion, the paper discusses causal interpretations that do not pre‐suppose a potential outcomes framework.
Characterization of hospital and community‐acquired respiratory syncytial virus in children with severe lower respiratory tract infections in Ho Chi Minh City, Vietnam, 2010
Authors: Tuan Tran Anh , Thanh Tran Tan , Hai Nguyen thi Thanh , Tinh Le Binh Bao , Kim Le thi Ngoc , Do Lien Anh Ha , Chinh B'Krong Nguyen thi Thuy , Tham Nguyen thi , Hang Vu thi Ty , Merson Laura , Farrar Jeremy , Thuong Tang Chi , de Jong Menno D. , Schultsz Constance , van Doorn H Rogier 
Published: February 2015

BackgroundHuman respiratory syncytial virus (RSV) is an important community and nosocomial pathogen in developed countries but data regarding the importance of RSV in developing countries are relatively scarce.MethodsDuring a 1‐year surveillance study in 2010, we took serial samples from children admitted to the Emergency Unit of the Respiratory Ward of Children's Hospital 1 in Ho Chi Minh City, Vietnam. RSV was detected within 72 hours of admission to the ward in 26% (376/1439; RSV A: n = 320; RSV B: n = 54; and RSV A and B: n = 2). Among those negative in the first 72 hours after admission, 6·6% (25/377) acquired nosocomial RSV infection during hospitalization (RSV A: n = 22; and RSV B: n = 3).ResultsChildren with nosocomial RSV infection were younger (P = 0·001) and had a longer duration of hospitalization (P < 0·001). The rate of incomplete recovery among children with nosocomial RSV infection was significantly higher than among those without (P < 0·001). Phylogenetic analysis of partial G gene sequences obtained from 79% (316/401) of positive specimens revealed the co‐circulation of multiple genotypes with RSV A NA1 being predominant (A NA1: n = 275; A GA5: n = 5; B BA3: n = 3; B BA9: n = 26; and B BA10: n = 7). The RSV A GA5 and RSV B BA3 genotypes have not been reported from Vietnam, previously.ConclusionBesides emphasizing the importance of RSV as a cause of respiratory infection leading to hospitalization in young children and as a nosocomial pathogen, data from this study extend our knowledge on the genetic diversity of RSV circulating in Vietnam.
Non‐Fulfilment of Debt Limits in Spanish Municipalities
Authors: Benito Bernardino , Guillamón María‐Dolores , Bastida Francisco 
Published: February 2015

AbstractIn decentralised European Monetary Union members such as Austria, Belgium, Finland, Germany and Spain, the Stability and Growth Pact can only be implemented if there is close fiscal coordination among government tiers. Thus, limits on subcentral governments' debt are essential in this coordination. This paper analyses which political and socio‐economic factors influence compliance with debt limits. We use a database with information on Spanish municipalities with at least 1,000 inhabitants for 2001–08. Our results indicate that the non‐financial surplus limit is the requirement that is most commonly breached, followed by the net operating balance requisite. Population has a positive and significant impact on failure to comply with debt limits. In addition, we show a positive relationship between income level and global limit compliance. Finally, it can be stated that municipalities appear to manipulate debt with electoral purposes.
Employment Quota System and Labour Market Outcomes of Individuals with Disabilities: Empirical Evidence from South Korea
Authors: Nazarov Zafar , Kang Dongug , von Schrader Sarah 
Published: February 2015

AbstractTo date, only a few studies have attempted to evaluate the effectiveness of disability employment quota systems using structural changes in policies. This study exploits the structural changes in South Korea's disability employment quota system that took place in 2004 and 2006 to expand the current disability policy evaluation literature. We separate the effect of these changes in the quota system into their effect on the probability of labour force participation and their effect on the probability of employment (after controlling for selection into the labour market). We also study the extent to which the changes – which included increasing the number of employers covered by the quota system, the number of jobs available to individuals with disabilities and the financial incentives for employing individuals with disabilities – have affected job satisfaction among individuals with disabilities. Our results suggest that the changes in the quota system may have increased labour force participation but have had a limited positive impact on the probability of employment among people with disabilities in South Korea. Further, compulsory hiring and expanded opportunities have not substantially affected the level of job satisfaction observed among employees with disabilities relative to their non‐disabled counterparts.
Practitioner Review: Pathways to care for ADHD – a systematic review of barriers and facilitators
Authors: Wright Nicola , Moldavsky Maria , Schneider Justine , Chakrabarti Ipsita , Coates Janine , Daley David , Kochhar Puja , Mills Jon , Sorour Walid , Sayal Kapil 
Published: February 2015

BackgroundAttention‐Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder starting in childhood that may persist into adulthood. It can be managed through carefully monitored medication and nonpharmacological interventions. Access to care for children at risk of ADHD varies both within and between countries. A systematic literature review was conducted to investigate the research evidence related to factors which influence children accessing services for ADHD.MethodStudies investigating access to care for children at risk of ADHD were identified through electronic searches of the international peer‐reviewed and grey literature. Databases were searched from inception till 30th April 2012. This identified 23,156 articles which were subjected to three levels of screening (title, abstract and full text) by a minimum of two independent reviewers. Due to the heterogeneity in the study designs, a narrative approach was used to present the findings.ResultsTwenty‐seven papers met the inclusion criteria; these were grouped into four main themes, with some papers being included in more than one. These were wider determinants (10 papers); identification of need (9 papers); entry and continuity of care (13 papers) and interventions to improve access (4 papers). Barriers and facilitators to access were found to operate at the individual, organisational and societal level. Limited evidence of effective interventions to improve access was identified.ConclusionThis review explored the multilayered obstacles in the pathway to care for children at risk of ADHD and the lack of evidence‐based interventions designed to address these issues, thereby indicating areas for service development and further evaluative research.
Spatially varying selection shapes life history clines among populations of Drosophila melanogaster from sub‐Saharan Africa
Authors: Fabian D. K. , Lack J. B. , Mathur V. , Schlötterer C. , Schmidt P. S. , Pool J. E. , Flatt T. 
Published: February 2015

AbstractClines in life history traits, presumably driven by spatially varying selection, are widespread. Major latitudinal clines have been observed, for example, in Drosophila melanogaster, an ancestrally tropical insect from Africa that has colonized temperate habitats on multiple continents. Yet, how geographic factors other than latitude, such as altitude or longitude, affect life history in this species remains poorly understood. Moreover, most previous work has been performed on derived European, American and Australian populations, but whether life history also varies predictably with geography in the ancestral Afro‐tropical range has not been investigated systematically. Here, we have examined life history variation among populations of D. melanogaster from sub‐Saharan Africa. Viability and reproductive diapause did not vary with geography, but body size increased with altitude, latitude and longitude. Early fecundity covaried positively with altitude and latitude, whereas lifespan showed the opposite trend. Examination of genetic variance–covariance matrices revealed geographic differentiation also in trade‐off structure, and QST‐FST analysis showed that life history differentiation among populations is likely shaped by selection. Together, our results suggest that geographic and/or climatic factors drive adaptive phenotypic differentiation among ancestral African populations and confirm the widely held notion that latitude and altitude represent parallel gradients.