bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of leukocyte telomere length to major cardiovascular diseases onset: insights from a large-scale genome-wide cross-trait analysis
Authors: Pauklin Siim , Qiao Jun , Wang Qian , Zhao Yuhui , Chang Minjing , Cai Liuyang , Liu Feng , Yao Kaixin , Zheng Leilei , Tan Ning , He Pengcheng , Jegga Anil , Jiang Lei , Yang Yining , Feng Yuliang 
Published: July 2024

Abstract

Telomere shortening, a marker of cellular aging and genomic instability, has been epidemiologically linked to an increased risk of various cardiovascular diseases (CVDs). However, shared genetic determinants involved in these associations remain unclear. We composed an atlas of the shared genetic associations between leukocyte telomere length (LTL) and six major CVDs by investigating shared genetic elements, encompassing SNPs, genes, biological pathways, and protein targets with pleiotropic implications. Extensive genetic overlaps beyond genetic correlations were observed, but no causal relationships were established. We identified 248 independent pleiotropic genomic risk loci, implicating 50 unique genes in two or more trait pairs, especially the SH2B3 gene, which was further validated by a proteome-wide Mendelian Randomization study. Functional analysis demonstrated a link to both DNA biosynthetic processes and telomere maintenance mechanisms. These findings suggest a genetic link between LTL and CVDs, highlighting a shared genetic basis crucial for developing future interventions and therapeutic targets.
LINC01354 affect glioma survival
Authors: Xu Jingxuan 
Published: July 2024

Abstract

Background
Gliomas are the most prevalent primary malignant brain tumors worldwide. Recent studies highlight the potential of long non-coding RNAs (lncRNAs) in tumor progression, with LINC01354 being upregulated in various malignancies. This study investigates the role of LINC01354 in glioma prognosis to provide novel insights for early prognosis prediction.
Methods
This study involved four cohorts of low-grade glioma tissue samples collected from hospitals in Xinjiang, Beijing, and Guangzhou, China. Quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) was used to measure LINC01354 expression levels. Clinical information and survival data were analyzed using Cox regression and ROC analysis to evaluate the association between LINC01354 expression and overall survival. Clinical comparisons were conducted to identify potential discrepancies in clinical parameters across different cohorts.
Results
Elevated LINC01354 levels were associated with poorer overall survival in the West China cohort (Xinjiang) but not in the North (Beijing) or South China (Guangzhou) cohorts. Clinical parameter comparisons revealed no significant differences among the cohorts that could explain the regional discrepancy. Further analysis within the West China cohort indicated that LINC01354's prognostic value was consistent across Han and non-Han ethnic groups and unaffected by dietary staples. However, LINC01354's prognostic significance was more pronounced in patients born in Xinjiang compared to those born elsewhere. A prognostic model incorporating LINC01354 expression and birth location demonstrated good predictive accuracy with ROC AUC values of 0.777 in the training cohort and 0.757 in the validation cohort.
Conclusion
LINC01354 is a potential prognostic biomarker for low-grade glioma in the West China population, particularly among patients born in Xinjiang.
Risk factors for functional state deterioration in patients with lymphatic malformation occuring in the neck region
Authors: Polev G. A. , Grachev N. S. , Oganesyan R. S. , Yaremenko E. Yu. 
Published: July 2024

Introduction. The improvement and prediction of functional status in patients with lymphatic malformations of the head and neck, particularly in neck masses, remains a pressing socio-economic concern. As of the publication of this article, no comprehensive scientific studies have explored the cause-and-effect relationships that impact the functional status of this specific patient demographic.Aim. To elucidate the cause-and-effect relationships impacting the functional status of patients with cervical lymphatic malformations and to develop a predictive model for their functional decline.Materials and methods. A retrospective cohort study was conducted, involving a detailed analysis of the functional status of 115 paediatric and adolescent patients aged 1 month to 17 years, treated for cervical lymphatic malformations at the Dmitry Rogachev National Medical Research Center for Pediatric Hematology, Oncology, and Immunology, from May 2012 to December 2022. The analysis utilised the Cologne Disease Score (CDS), varying according to the histological type of the lymphatic malformations (microcystic, macrocystic, or mixed) and the staging of the de Serres classification.Results and discussion. The study involved 115 patients with a median age of 2.1 years (ranging from 0.4 to 5.5 years). It was determined that the ‘Mixed lymphatic malformations type,’ ‘Stage V of the de Serres classification,’ and ‘Need for surgical treatment’ were clinically and statistically significant prognostic factors for the deterioration of functional status in these patients, reducing the CDS scores by 0.976 to 4.514 points, respectively. These findings supported the development of a predictive model for worsening functional status in this group.Conclusion. The predictive model formulated during this research accounts for the histological type, location, and treatment modality, and is recommended for clinical application within specialised medical institutions.
Quaternization-based graft modification of straw fibers for conditioning the sludge dewatering performance
Authors: Zhang Qingfang , Zhao Yanbin , Yang Qiyong , Xu Binjie , Zhang Xinhua , Xiong Houfeng , Zhou Han , Xiao Ruimin 
Published: July 2024

ABSTRACT

Extracellular polymeric substances (EPS) are a critical influencing factor in sludge dewatering. Disrupting such EPS contributes to the release of bound water in sludge, enhancing the sludge dewatering performance. In This study, quaternized straw fibers that are destructive to the EPS structure and components in active sludge were prepared useing heterogeneous free radical graft polymerization. Straw fibers, dimethyl diallyl ammonium chloride (DMDAAC), ammonium persulfate (APS), and acrylamide (AM) were taken as the substrate, grafting monomer, catalyst, and cross-linking agent, respectively.The optimal processing conditions determined for the DMDAAC-based quaternization and graft modification of straw fibers were as follows: reaction temperature of 60 °C, reaction time of 5 h, 0.100 g of catalyst APS dosage per gram of straw, and 3.000 ml of DMDAAC dosage per gram of straw. The optimal processing conditions yielded 1.335 g of modified straw fibers per gram of straw, 33.67% grafting rate, and 31.70% substitution of the quaternary ammonium groups. The capillary suction time (CST) was conditioned from 243.3 ± 22.6 s in the original sludge to 134.5 ± 34.45 s. The specific resistance to filtration (SRF) was reduced from 8.82 ± 0.51 × 1012 m/kg in the original sludge to 4.59 ± 0.23 × 1012 m/kg.
Searching Heterocyclic Scaffolds Used to Treat Alzheimer’s Disease: A
Review
Authors: Kale Mayura A , Faisal Mohammed 
Published: July 2024

Abstract::
It is a known fact that Alzheimer's disease causes degeneration of the central nervous
system, which progresses and causes memory loss as well as loss of cognition. For many years,
extensive research has been undertaken to find out newer possibilities to fight this disease at a
molecular level along with many long-standing and expensive clinical trials. Many scientific
research programs have either been discarded or unsuccessful. However, the research has not
stopped and in the process, many heterocyclic scaffolds have been tried to build up novel drug
molecules to combat this disease. A literature survey reveals that many heterocycles have been
explored and were found to be very useful in treating many neurodegenerative disorders, including
Alzheimer’s disease, Parkinsonism and a few more. This review explains the journey
and highlights the various strategies to develop new anti-Alzheimer drug candidates. It is a concise
and rigorous literature excerpt involving research findings on heterocyclic scaffolds for
treating this disease.
On the diffusive model of C<sub>60</sub> fullerene clusterization in liquids
Authors: Elnikova L. V. , Shevchenko V. G. , Kuzmenko A. P. 
Published: July 2024

Purpose of research. The purpose of the study is to explain the mechanisms of clustering of fullerene molecules in liquid media observed using various structural nuclear -physical methods, as well as the interpretation of experimental data within the framework of a microscopic diffusion model. Methods. The article gives a brief overview of the results of positron annihilation spectroscopy, small-angle neutron scattering, translucent electron microscopy, with which the geometric parameters of fullerene clusters in solutions were established. The theoretical method of research is the microscopic diffusion model “Limited diffusion aggregation”, which describes the kinetic processes of clusterization. Results. The diffusion limited aggregation model displays adequately the mechanism of formation of C60 molecules in the form of fractal units in the volume of fluid, observed in experiments on positron annihilation spectroscopy and small-angle neutron scattering. The structural indicators of aggregate fullerene particles in carbon disulfide, o-Xylene, toluene, water and other solvents are analyzed. The properties of various diffusion models (the reaction limited aggregation model and the diffusion limited aggregation model) are considered and their combination in relation to the assessmentsof the kinetics of fullerene aggregation in solutions. A quantitative comparison of the results of the discussed models was carried out using the example of carbon disulfide. Conclusion. The diffusion microscopic models adequately describe the phenomenon of fullerene aggregation in polar and non-polar solvents, which are recorded by various nuclear methods (positron annihilating spectroscopy and small-angle neutron scattering), the most reliable is the diffusion limited aggregation model, more than that, it is the basis of a numerical definition of structural structures parameters of units. Compared to neutron scattering, with the annihilation of positrons, in the aggregation of fullerene the [Ps–C60] molecular complexes participate in the clusterization, but this does not affect the change in the size of the cluster and the reliability of the results.
Structure and properties of powders obtained by electrodispersion of pure tungsten metal waste in distilled water
Authors: Ageeva E. V. , Ulitin D. A. , Korolev M. S. , Ageeva A. E. 
Published: July 2024

Purpose. Investigation of the composition, structure and properties of powder materials obtained by electrodispersion of tungsten waste of the VA brand in an oxygen–containing medium - distilled water. Methods. To determine the composition, structure and properties of powder materials, samples of powders obtained from waste tungsten of the VA brand were studied. The powder material was obtained by electroerosive dispersion in distilled water. Microanalysis of powder particles was carried out using a scanning electron microscope, analysis of the size distribution of powder particles was obtained using a particle size analyzer, X-ray spectral microanalysis of powder particles was carried out using an energy dispersive X-ray analyzer integrated into a scanning electron microscope, analysis of the phase composition of powder particles was carried out using X-ray diffraction on a diffractometer. Results. During the study, it was revealed that the shape of the particles obtained from powdered tungsten materials is spherical and elliptical, and agglomerates of smaller particles are also marked on magnification. Oxygen and tungsten are present in the composition of powder materials, while there are no joint structural components. The phases of pure tungsten in α and β modifications are noted in the phase composition. It follows from the analysis of the granulometric histogram that the particle size spread varies in the range of 0.092–62.59 microns, while the average particle diameterwas 5.73 microns. Conclusion. The obtained research results can be used to develop a new heavy pseudo-alloy using metal waste of expensive raw materials by the method of electroerosive dispersion with subsequent improvement and optimization of the composition and structure of the alloy.
Design and Psychometric Evaluation of Nurses’ Mobile Health Device Acceptance Scale (NMHDA-Scale): Application of the Expectation-Confirmation Theory
Authors: Mirabootalebi Narjes , Meidani Zahra , Akbari Hossein , Rangraz Jeddi Fatemeh , Tagharrobi Zahra , Swoboda Walter , Holl Felix 
Published: July 2024

Background
The use of mobile tools in nursing care is indispensable. Given the importance of nurses’ acceptance of these tools in delivering effective care, this issue requires greater attention.

Objective
This study aims to design the Mobile Health Tool Acceptance Scale for Nurses based on the Expectation-Confirmation Theory and to evaluate it psychometrically.

Methods
Using a Waltz-based approach grounded in existing tools and the constructs of the Expectation-Confirmation Theory, the initial version of the scale was designed and evaluated for face and content validity. Construct validity was examined through exploratory factor analysis, concurrent validity, and known-group comparison. Reliability was assessed using measures of internal consistency and stability.

Results
The initial version of the scale consisted of 33 items. During the qualitative and quantitative content validity stage, 1 item was added and 1 item was removed. Exploratory factor analysis, retaining 33 items, identified 5 factors that explained 70.53% of the variance. A significant positive correlation was found between the scores of the designed tool and nurses’ attitudes toward using mobile-based apps in nursing care (r=0.655, P<.001). The intraclass correlation coefficient, Cronbach α, and ω coefficient were 0.938, 0.953, and 0.907, respectively.

Conclusions
The 33-item scale developed is a valid and reliable instrument for measuring nurses’ acceptance of mobile health tools.
Quality of Chronic Obstructive Pulmonary Disease Information on the Chinese Internet: Website Evaluation Study
Authors: Wang Qinqin , Liu Lingjun , Li Hong , Zhang Qiao , Ma Qianli 
Published: July 2024

Background
The development of internet technology has greatly increased the ability of patients with chronic obstructive pulmonary disease (COPD) to obtain health information, giving patients more initiative in the patient-physician decision-making process. However, concerns about the quality of website health information will affect the enthusiasm of patients’ website search behavior. Therefore, it is necessary to evaluate the current situation of Chinese internet information on COPD.

Objective
This study aims to evaluate the quality of COPD treatment information on the Chinese internet.

Methods
Using the standard disease name “慢性阻塞性肺疾病” (“chronic obstructive pulmonary disease” in Chinese) and the commonly used public search terms “慢阻肺” (“COPD”) and “肺气肿” (“emphysema”) combined with the keyword “治疗” (“treatment”), we searched the PC client web page of Baidu, Sogou, and 360 search engines and screened the first 50 links of the website from July to August 2021. The language was restricted to Chinese for all the websites. The DISCERN tool was used to evaluate the websites.

Results
A total of 96 websites were included and analyzed. The mean overall DISCERN score for all websites was 30.4 (SD 10.3; range 17.3-58.7; low quality), no website reached the maximum DISCERN score of 75, and the mean score for each item was 2.0 (SD 0.7; range 1.2-3.9). There were significant differences in mean DISCERN scores between terms, with “chronic obstructive pulmonary disease” having the highest mean score.

Conclusions
The quality of COPD information on the Chinese internet is poor, which is mainly reflected in the low reliability and relevance of COPD treatment information, which can easily lead consumers to make inappropriate treatment choices. The term “chronic obstructive pulmonary disease” has the highest DISCERN score among commonly used disease search terms. It is recommended that consumers use standard disease names when searching for website information, as the information obtained is relatively reliable.
Migrantes haitianos en Tijuana.Surgimiento y consolidación de la primera comunidad afrodescendiente en el norte de México
Authors: Rentería Pedraza Victor Hugo , Albañez Rodríguez Marlenny , Rocha David 
Published: June 2024

El objetivo de la investigación fue determinar si los migrantes haitianos que arribaron a Tijuana desde 2016, van formando y consolidando la primera comunidad afrodescendiente en el norte de México; para el efecto se diseñó e implementó una encuesta, así como entrevistas semiestructuradas, encaminadas a captar información respecto al arraigo y a la integración con la comunidad local, medidas a partir de la capacidad para integrarse social y laboralmente, el ejercicio de la cultura propia y la incorporación de elementos de la cultura local, así como la satisfacción con el empleo, el salario y la capacidad e intención de adquirir bienes muebles e inmuebles. El estudio concluye que existen elementos que corroboran la formación de la comunidad haitiana y así la primera comunidad afrodescendiente en el norte de México, enriqueciendo la diversidad nacional e internacional, en Tijuana.
Factores asociados al rendimiento académico en estudiantes universitarios de Latinoamérica en 2023
Authors: Real-Delor Raúl Emilio , Guevara Tirado Alberto , Morales Ojeda Ismael Antonio , Chibas Muñóz Eduardo Enrique , Cañete Cáceres Elena Denice , Carballo Almeida María José , Flor Lugo Dalba Noemí , Noldin Villasanti Ana Elisa , Pereira Salles Vitor , Sanabria Cañete Néstor Fabián , Alvarenga Ferreira María Eugenia , Ríos Pagnussatt Matheus , Zaracho Miranda Araceli , González Vera Guillermo Rafael 
Published: June 2024

Introducción: El rendimiento académico de los estudiantes universitarios puede estar influenciado por diversos factores, como el apoyo que reciben los mismos de sus familias.
Objetivo: Determinar los factores asociados a la percepción del rendimiento académico en estudiantes universitarios de Latinoamérica en 2023.
Método: Se aplicó un diseño de corte transversal. Se incluyó a estudiantes de diversas carreras universitarias que aceptaban completar un cuestionario en línea difundido por redes sociales en Paraguay, Perú, Chile y Cuba. El cuestionario midió datos demográficos, la percepción de rendimiento académico y el apoyo familiar. Se excluyeron los cuestionarios incompletos. Se aplicó estadística descriptiva y analítica. El estudio fue aprobado por el Comité de Ética.
Resultados: Fueron incluidos 500 universitarios, la mayoría de Paraguay (53.4%). Predominó el sexo femenino (75.4%). Las carreras más frecuentes eran del área de la salud (94.6%). El 91.4% asistía a universidades privadas y 72.4% no disponía de ingresos económicos propios. Los estudiantes percibieron buen rendimiento académico en 38.8% y apoyo familiar en 40%. El mal rendimiento académico se correlacionó significativamente con la disfunción familiar (p < 0.001).
Conclusiones: El apoyo familiar fue un factor de buen rendimiento académico en los estudiantes universitarios. Se recomienda explorar periódicamente la funcionalidad familiar para apoyar a los estudiantes que refieran falta de esta.
Assessment of Depression and Anxiety Among Public Health Students: A Cross-Sectional Study in University of Hail, Saudi Arabia
Authors: Kumar Rakesh 
Published: July 2024

Objective: The study aims to identify the socio-demographic and lifestyle factors associated with depression, and anxiety among public health students at the University of Hail in Saudi Arabia.
Methods: The researchers collected responses from 446 participants using a convenience sampling approach through a cross-sectional quantitative research design. The collected data underwent analysis through descriptive statistics, focusing on socio-demographic and lifestyle factors. Additionally, the measure of association is used to verify the associations of these factors with depression and anxiety among public health students of the University of Hail in Saudi Arabia. Finally, the binary logistic regression is used to identify the impacts of various socio-demographic, and lifestyle factors on mild to severe anxiety and depression of these students.
Results: The research proves that lower family income and bad relationships with classmates are significant demographic factors, while unsatisfied sleep, smoking habits, and symptoms ranging from mild to severe depression are lifestyle factors that contribute to heightened anxiety among public health students at the University of Hail in Saudi Arabia. Additionally, it was also found that transitional age (21-25 years) from socio-demographic factors, unsatisfied sleep level, smoking habit, and mild to severe symptoms of anxiety also cause significant increased depression among these students.
Conclusion: The study concludes that students who are not satisfied with their sleep, and have a smoking status are more exposed to anxiety as well as depression as compared to non-smokers, and the students with satisfied sleep. Additionally, those students who are not good in relationships with their classmates, and have mild to severe symptoms of depression are exposed to anxiety significantly. Finally, those students having a transitional age of 21-25 years along with mild to severe symptoms of anxiety are significantly exposed to depression.
Myanmar Military Coup: Can ICCPR Protect Civil Society?
Authors: Pasha Vanhar Camal , Novianti Novianti , Harahap Rahayu Repindowaty 
Published: June 2024

Abstrak
Penelitian ini bertujuan untuk mengetahui bagaimana International Convention On Civil And Political Right melindungi Masyarakat Sipil Myanmar dalam Kasus Kudeta Militer Myanmar serta bagaimana perlindungan hukum terhadap masyarakat sipil Myanmar terhadap konflik yang terjadi di wilayah tersebut. Penelitian ini merupakan penelitian hukum yuridis normatif (normativelegal res earch). Dengan pendekatan perundang â€“ undangan (statute approach), pendekatan kasus (case approach) dan pendekatan konseptual (conceptual approach). Berdasarkan penelitian, bahwa didalam konvensi hak â€“ hak sipil dan politik terdapat ketentuan yang mengatur dan menjamin hak â€“ hak masyarakat sipil, namun hak â€“ hak masyarakat sipil di Myanmar tidak dijamin dikarenakan konflik kudeta dan perebutan kekuasaan di negara tersebut. Hal ini menunjukkan bahwa konvensi hak â€“ hak sipil dan politik belum optimal menjamin perlindungan hak masyarakat sipil tersebut. Serta bagaimana peran ASEAN dalam menyelesaikan konflik yang di lakukan militer Myanmar terhadap masyarakat sipil Myanmar. Bentuk â€“ bentuk perlindungan masyarakat sipil Myanmar terdapat dalam rule of law yang ada serta bila ada masalah, persoalan ini diselesaikan di tingkat KTT atau ASEAN Summit.