bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental Assessment of a Vision-Based Obstacle Avoidance Strategy for Robot Manipulators: Off-line Trajectory Planning and On-line Motion Control
Authors: Scoccia Cecilia , Ubezio Barnaba , Palmieri Giacomo , Rathmair Michael , Hofbaur Michael 
Published: July 2024

AbstractHuman-Robot Interaction is an increasingly important topic in both research and industry fields. Since human safety must be always guaranteed and accidental contact with the operator avoided, it is necessary to investigate real-time obstacle avoidance strategies. The transfer from simulation environments, where algorithms are tested, to the real world is challenging from different points of view, e.g., the continuous tracking of the obstacle and the configuration of different manipulators. In this paper, the authors describe the implementation of a collision avoidance strategy based on the potential field method for off-line trajectory planning and on-line motion control, paired with the Motion Capture system Optitrack PrimeX 22 for obstacle tracking. Several experiments show the performance of the proposed strategy in the case of a fixed and dynamic obstacle, disturbing the robot’s trajectory from multiple directions. Two different avoidance modalities are adapted and tested for both standard and redundant robot manipulators. The results show the possibility of safely implementing the proposed avoidance strategy on real systems.
Empagliflozin and dapagliflozin decreased atrial monoamine oxidase expression and alleviated oxidative stress in overweight non-diabetic cardiac patients
Authors: Ionică Loredana N. , Buriman Darius G. , Lința Adina V. , Șoșdean Raluca , Lascu Ana , Streian Caius G. , Feier Horea B. , Petrescu Lucian , Mozoș Ioana M. , Sturza Adrian , Muntean Danina M. 
Published: July 2024

Abstract
The sodium-glucose-cotransporter 2 inhibitors (SGLT2i) are the blockbuster antidiabetic drugs that exert cardiovascular protection via pleiotropic effects. We have previously demonstrated that empagliflozin decreased monoamine oxidase (MAO) expression and oxidative stress in human mammary arteries. The present study performed in overweight, non-diabetic cardiac patients was aimed to assess whether the two widely prescribed SGLT2i decrease atrial MAO expression and alleviate oxidative stress elicited by exposure to angiotensin 2 (ANG2) and high glucose (GLUC). Right atrial appendages isolated during cardiac surgery were incubated ex vivo with either empagliflozin or dapagliflozin (1, 10 µm, 12 h) in the presence or absence of ANG2 (100 nm) and GLUC (400 mg/dL) and used for the evaluation of MAO-A and MAO-B expression and ROS production. Stimulation with ANG2 and GLUC increased atrial expression of both MAOs and oxidative stress; the effects were significantly decreased by the SGLT2i. Atrial oxidative stress positively correlated with the echocardiographic size of heart chambers and negatively with the left ventricular ejection fraction. In overweight patients, MAO contributes to cardiac oxidative stress in basal conditions and those that mimicked the renin–angiotensin system activation and hyperglycemia and can be targeted with empagliflozin and dapagliflozin, as novel off-target class effect of the SGLT2i.
Iron Reduces the Trafficking of Fatty Acids from Human Immortalised Brain Microvascular Endothelial Cells Through Modulation of Fatty Acid Transport Protein 1 (FATP1/SLC27A1)
Authors: Supti Showmika T. , Koehn Liam M. , Newman Stephanie A. , Pan Yijun , Nicolazzo Joseph A. 
Published: July 2024

Abstract
Purpose
Alzheimer’s disease (AD) is associated with brain accumulation of amyloid-beta (Aβ) and neurofibrillary tangle formation, in addition to reduced brain docosahexaenoic acid (DHA) and increased brain iron levels. DHA requires access across the blood–brain barrier (BBB) to enter the brain, and iron has been shown to affect the expression and function of a number of BBB transporters. Therefore, this study aimed to assess the effect of iron on the expression and function of fatty acid binding protein 5 (FABP5) and fatty acid transport protein 1 (FATP1), both which mediate brain endothelial cell trafficking of DHA.

Methods
The mRNA and protein levels of FABP5 and FATP1 in human cerebral microvascular endothelial (hCMEC/D3) cells was assessed by RT-qPCR and Western blot, respectively following ferric ammonium citrate (FAC) treatment (up to 750 µM, 72 h). The function of FABP5 and FATP1 was assessed via uptake and efflux of radiolabelled 3H-oleic acid and 14C-DHA.

Results
FAC (500 µM, 72 h) had no impact on the expression of FABP5 at the protein and mRNA level in hCMEC/D3 cells, which was associated with a lack of effect on the uptake of 14C-DHA. FAC led to a 19.7% reduction in FATP1 protein abundance in hCMEC/D3 cells with no impact on mRNA levels, and this was associated with up to a 32.6% reduction in efflux of 14C-DHA.

Conclusions
These studies demonstrate a role of iron in down-regulating FATP1 protein abundance and function at the BBB, which may have implications on fatty acid access to the brain.

Graphical Abstract
Mathematical Structures Within Simple Type Theory
Authors: González-Castillo Samuel 
Published: July 2024

AbstractWe present an extension of simple type theory that incorporates types for any kind of mathematical structure (of any order). We further extend this system allowing isomorphic structures to be identified within these types thanks to some syntactical restrictions; for this purpose, we formally define what it means for two structures to be isomorphic. We model both extensions in NFU set theory in order to prove their relative consistency.
Using novel data and ensemble models to improve automated labeling of Sustainable Development Goals
Authors: Wulff Dirk U. , Meier Dominik S. , Mata Rui 
Published: July 2024

AbstractA number of labeling systems based on text have been proposed to help monitor work on the United Nations (UN) Sustainable Development Goals (SDGs). Here, we present a systematic comparison of prominent SDG labeling systems using a variety of text sources and show that these differ considerably in their sensitivity (i.e., true-positive rate) and specificity (i.e., true-negative rate), have systematic biases (e.g., are more sensitive to specific SDGs relative to others), and are susceptible to the type and amount of text analyzed. We then show that an ensemble model that pools SDG labeling systems alleviates some of these limitations, exceeding the performance of the individual SDG labeling systems considered. We conclude that researchers and policymakers should care about the choice of the SDG labeling system and that ensemble methods should be favored when drawing conclusions about the absolute and relative prevalence of work on the SDGs based on automated methods.
A taxonomic revision of the genus Hydnora (Hydnoraceae)
Authors: Hatt Sebastian A. , Thorogood Chris J. , Bolin Jay F. , Musselman Lytton J. , Cameron Duncan D. , Grace Olwen M. 
Published: July 2024

SummaryA systematic monograph is presented for Hydnora (Hydnoraceae), a poorly known genus of holoparasitic plants distributed across Africa, Madagascar and southern Arabia. Species of Hydnora are characterised by their underground habit, unusual fleshy flowers and complete absence of leaves or photosynthetic tissue. This is the first detailed monograph of the genus Hydnora since 1935 and is informed by a comprehensive survey of herbarium specimens and literature. Detailed descriptions, full synonymy, distribution maps and discussion concerning confusable taxa are provided for each species, along with notes on ethnobotany, ecology and conservation. We place particular emphasis on the taxonomic value of osmophore geometry and positioning in living and dried material, which are highly consistent within species. We also provide the first detailed assessment of host range across the genus. Hydnora hanningtonii Rendle and H. solmsiana Dinter are reinstated from synonymy, and H. bolinii S.Hatt is newly described here. The infrageneric classification is reviewed and a key is provided for both living and dried material. Species are accompanied by both illustrations and photographs of living and dried material where possible.
Inhibition of Hsp90 K284 Acetylation Aalleviates Cardiac Injury After Ischemia–Reperfusion Injury
Authors: Zhan Dongyu , Zhang Na , Zhao Li , Sun Zhirui , Cang Chunyang 
Published: July 2024

AbstractOur objective was to determine the role of acetyl-Hsp90 and its relationship with the NF-κB p65 signaling pathway in CVDs. We investigated the effect of acetyl-Hsp90 on cardiac inflammation and apoptosis after ischemia–reperfusion injury (I/RI). The results showed that the induction of acetyl-Hsp90 occurred in the heart during I/R and in primary cardiomyocytes during oxygen–glucose deprivation/reoxygenation (OGD/R). Moreover, the nonacetylated mutant of Hsp90 (Hsp90-K284R), through the regulation of ATPase activities within its N-terminal domain (NTD), indirectly or directly increases its interaction with NF-κB p65. This led to a reduction in the activation of the NF-κB p65 pathway, thereby attenuating inflammation, apoptosis, and fibrosis, ultimately leading to an improvement in cardiac function. Furthermore, we demonstrated that recombinant human interleukin-37 (rIL-37) exerts a similar cardioprotective effect by reducing acetylation at K284 of Hsp90 after inhibiting the expression of KAT2A.
Graphic Abstract
Hsp90 is acetylated by KAT and can be deacetylated by KDAC, which is in balance in the steady state. Moreover, Hsp90 interacts with NF-κB p65 in the cytosol and inhibits p65 translocation into the nucleus. However, Hsp90-K284 can be acetylated by KAT2A after ischemia–reperfusion treatment. Subsequently, the protein–protein interaction between Hsp90 and NF-κB p65 was disturbed, which induced NF-κB p65 to translocate into the nucleus. However, rIL-37 disturbs this phenotype by inhibiting KAT2A activity.
Sustained clinical and histopathological remission in a patient with eosinophilic esophagitis and type-2 comorbidities at 18 months after discontinuation of dupilumab
Authors: González-Uribe Víctor , Rodríguez-Bueno Carlos Patricio Acosta , Mojica-González Zaira Selene , Malagón-Liceaga Andrea , Basile-Alvarez Martín Roberto 
Published: July 2024

AbstractEosinophilic esophagitis (EoE) is a chronic, allergen-mediated, type-2 inflammatory disease with the potential to significantly impact an individual’s quality of life. Conventional treatments often result in varied responses, prompting the need for novel therapeutic approaches. We present the case of a 19-year-old male with a medical history marked by eosinophilic esophagitis, severe atopic dermatitis (AD), asthma, and allergic rhinitis. Despite undergoing diverse topical and systemic interventions to address his AD and EoE, the patient’s symptoms persisted. However, following the initiation of dupilumab therapy—a dual IL-4 and IL-13 receptor antagonist—the patient experienced a substantial reduction in his Eczema Area and Severity Index score. Notably, a marked improvement was also seen regarding his symptoms of eosinophilic esophagitis. A subsequent esophageal biopsy revealed a significant decrease in eosinophilic inflammation, consistent with established clinical and histologic remission criteria. These findings corroborate the patient’s reported relief from symptoms. This case underscores the potential efficacy of dupilumab as a promising therapeutic agent in managing eosinophilic esophagitis. Dupilumab offers a dual benefit of alleviating symptoms and achieving histologic and clinical remission. This novel approach presents a noteworthy advancement in the treatment of EoE.
The potential of cancer stem cells for personalized risk assessment and therapeutic intervention in individuals with intrahepatic cholangiocarcinoma
Authors: Zhang Jian , Cui Tao , Xu Jiaobang , Wang Peng , Lv Chongqing , Pan Guozheng 
Published: July 2024

Abstract
Background
Accumulating evidence suggests that intrahepatic cholangiocarcinoma (ICC) is a stem cell-based disease, but information on the biology of cancer stem cells (CSC) in ICC is very limited.

Methods
ICC RNA-seq cohorts from three different public databases were integrated and the protein-coding genes were divided into different modules using "WGCNA" to screen the most relevant modules with CSC scores. Least Absolute Shrinkage and Selection Operator (LASSO) regression were introduced to construct prognostic classification models. In addition, the extent of immune cell infiltration in patients in different risk groups was assessed based on the ESTIMATE, CIBERSORT, MCP-Counter, and single sample gene set enrichment analysis (ssGSEA) algorithms. Finally, the correlation between different risk scores and common drugs was analyzed by pRRophetic package and Spearman method.

Results
In the present study, we found that a high CSC score was associated with a poorer prognosis in patients with ICC. The yellow module obtained by WGCNA was significantly positively correlated with the CSCs score, in which 8 genes were served to build a prognostic classification model, and the obtained risk score was negatively correlated with CSCs score and prognosis. The low-risk score was more suitable for immunotherapy, and the high-risk score was more suitable for treatment with 11 antitumor drugs.

Conclusion
This study revealed the regulatory role of CSC-mediated EMT, angiogenesis, and immunomodulatory biological processes in ICC, and applied a prognostic classification model to highlight the great potential of CSC for personalized risk assessment, chemotherapy, and immunotherapy intervention in ICC individuals.
A Qualitative Study Exploring Aging Gay and Bisexual Men’s Needs From Healthcare Services in Israel
Authors: Ifrah Kfir , Kempler Noam , Shenkman Geva 
Published: July 2024

Abstract
Introduction
Older gay and bisexual men are exposed to heightened risks of physical and mental health disorders. Therefore, understanding their unique needs from healthcare services is essential and is set at the focus of the present study.

Methods
The current qualitative study explored aging gay and bisexual men’s unique experiences and needs from healthcare services in Israel. Participants (N = 80, age range 47–82, M = 59.59, SD = 7.40) were interviewed in the years 2018–2020 and queried regarding their needs from and experiences with healthcare services, which were later thematically analyzed using Braun and Clarke’s Thematic Analysis.

Results
Six themes were identified from participants’ responses: Romantic relationships and parenting, sexuality in old age, ageism, loneliness, the need for a unique support framework for the gay and bisexual communities, and perceived factors preventing accessibility to healthcare services.

Conclusions
The results revealed certain barriers for attaining healthcare services as well as the need for distinctive health and psychological services for gay and bisexual men.

Policy Implications
The participants’ unique experiences and needs may aid in offering useful solutions for policy makers, social agents, and clinicians in order to improve healthcare services utilized by aging gay and bisexual men.
Gas component effect on energy loss of reciprocated engine operated by bio-syngas from wood gasifier
Authors: Enomoto Hiroshi 
Published: July 2024

AbstractTo convert woody biomass into electricity with small capacity and high efficiency, it is reasonable to gasify the woody biomass and operate a reciprocating engine. On the other hand, bio-syngas produced from woody biomass have a low calorific value. Therefore, if the concepts of the thermal efficiency and the losses (the cooling loss, the combustion loss, the pumping loss, the exhaust loss, etc.) obtained by conventional fossil fuels are applied as these are, it is not possible to predict the thermal efficiency appropriately. In this paper, the bio-syngas as the reference is produced in a self-made gasification system, and the thermal efficiency and the losses of the reciprocating engine are experimentally examined to evaluate the significant effect of combustible components on these indicators. The combustible components are hydrogen, methane, and carbon monoxide. The nitrogen fraction in the bio-syngas is adjusted to control the low heating value. A commercially available small general-purpose spark-ignition reciprocating engine (GP-SIRE) was modified and used as the experimental engine. The results showed that (1) the operation with the referenced bio-syngas exhibits higher thermal efficiency (more than 10 points) than that with the conventional methane, and that (2) there is a trade-off between the combustion loss and the cooling loss.
Positive, challenging, or impossible self-managing organizations? Exploring radical decentralization at an addiction rehabilitation center
Authors: Jensen Tobias Berggren , Mikkelsen Elisabeth Naima 
Published: July 2024

AbstractSelf-management has been explored in research for more than half a century and is said to be linked to several positive effects ranging from a more egalitarian and democratic structure to enhanced productivity, improved quality of work and greater adaptability. More recently, the self-managing organization (SMO) has emerged as a novel organizational structure that departs from managerial hierarchy through radical decentralization. However, only a few empirical scientific studies have explored how radically decentralized structures of SMOs create new dynamics for organizations and the people in them. In this paper, we present the case of a public sector addiction rehabilitation center that had developed into an SMO through radical decentralization of managerial authority to staff. We use narrative theory as an enriching theoretical perspective to examine critically staff and managers’ subjective experiences of working in the SMO, finding that work was experienced as not only positive and challenging but also impossible. While positive experiences included increased collective responsibility, well-being, and efficiency within teams, conflict and disidentification emerged between teams, challenging the decentralized structure and, in some instances, making work within that context impossible. By drawing on these findings, we extend our understanding of SMOs.
Microstructural analysis and densification of ordinary Portland cement mortars incorporated with minimal nano-TiO2: intermixing and surface coating on both fresh and hardened surfaces
Authors: Reddy N. Avinash , Chandana P. Sri 
Published: July 2024

AbstractThe present study investigated the microstructural properties of ordinary Portland cement (OPC)-modified with minimum dosage of nano TiO2 on fresh and hardened cement mortar surfaces and intermixed samples. X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) were used to analyze the morphology and hydration products of the OPC specimens doped with nanotitanium (NT).Additionally, XRD coupled with Rietveld refinement was employed to quantify the crystal phases and refine the crystal structure model through the comparison of the calculated diffraction pattern to the measured pattern. Subsequently, crystallographic analysis was conducted to evaluate the crystallographic structure and to confirm the existence of specific atoms and bonds within the crystal structure altered with NT. The findings revealed that the addition of minimal NT resulted in a more compact and denser microstructure, characterized by increased formation of calcium silicate hydrate (CSH) gel and a reduction in calcium hydroxide (CH) crystals.This led to a reduction in the porosity of the hardened coating surface, with similar improvements observed for the fresh coating and intermixed samples compared to those of the control mortar. A decrease in the lattice parameters, accompanied by an increase in the number of atoms, bonds and polyhedra in the crystal structure, led to alterations in the interatomic spacing and contributed to the densification of the cementitious matrix.The findings also showed that NT integration led to a more compact structure with shorter bond distances and smaller polyhedral volumes for the Ti samples than for the control sample. Moreover, compared with the freshly cast and hardened coating samples, the NT-intermixed samples exhibited the shortest Ti–O bond distances and the smallest polyhedral volume. Overall, the analysis presented in this study significantly contributes to the development of novel and environmentally friendly photocatalytic cementitious materials at minimal dosages.
Landslide hazard zonation (LHZ) mapping of Doon Valley using multi-criteria analysis method based on remote sensing and GIS techniques
Authors: Mani Ashish , Kumari Maya , Badola Ruchi 
Published: July 2024

AbstractThe occurrence of landslides is a costly and cataclysmic natural hazard that mainly occurs in hilly areas due to factors like earthquakes, cloud burst, extreme rainfall, human pressure, etc. leading to loss of biodiversity, property, and life. Effective and comprehensive landslide risk management is crucial to address landslide susceptibility. Utilizing remote sensing and Geographic Information System (GIS) techniques, this work focuses on the landslide hazard zonation (LHZ) mapping. The study is specifically conducted in the Doon Valley. These advanced technologies help in identifying and categorizing the areas prone to landslides. The Shuttle Radar Topography Mission (SRTM) Digital Elevation Model (DEM) data at 30 m resolution and Sentinel-2B data at 10 m resolution were used to perform the remote sensing and GIS operations in ArcGIS Software. Thematic layers such as Land Use/Land Cover (LULC), Slope, Geology, Soil Type, Elevation, Drainage Density, Vegetation, and Aspect were produced utilizing remote sensing and GIS data. The weighted overlay, a multi-criteria analysis method, was applied to assign attribute values to each thematic layer based on their importance, which was then combined to calculate the landslide hazard zone. The findings of this study demonstrate that landslides are more likely to occur near and above the Main Boundary Thrust/Fault (MBT). The high to very high hazard zone covers 16.64% of the total area, making landslides occurring more frequently. Additionally, the study found that the Doon Valley rivers’ upper segments are more susceptible to landslides than their lower segments. By integrating Remote Sensing and GIS techniques, it is possible to obtain extensive knowledge of regions prone to landslides. This information will be helpful for decision-makers and planners to reduce the impact of landslides in the near future.