bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommendations for minimum information for publication of experimental pathology data: MINPEPA guidelines
Authors: Scudamore Cheryl L , Soilleux Elizabeth J , Karp Natasha A , Smith Ken , Poulsom Richard , Herrington C Simon , Day Michael J , Brayton Cory F , Bolon Brad , Whitelaw Bruce , White Eric S , Everitt Jeffrey I , Arends Mark J 
Published: September 2015

AbstractAnimal models are essential research tools in modern biomedical research, but there are concerns about their lack of reproducibility and the failure of animal data to translate into advances in human medical therapy. A major factor in improving experimental reproducibility is thorough communication of research methodologies. The recently published ARRIVE guidelines outline basic information that should be provided when reporting animal studies. This paper builds on ARRIVE by providing the minimum information needed in reports to allow proper assessment of pathology data gathered from animal tissues. This guidance covers aspects of experimental design, technical procedures, data gathering, analysis, and presentation that are potential sources of variation when creating morphological, immunohistochemical (IHC) or in situ hybridization (ISH) datasets. This reporting framework will maximize the likelihood that pathology data derived from animal experiments can be reproduced by ensuring that sufficient information is available to allow for replication of the methods and facilitate inter‐study comparison by identifying potential interpretative confounders. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
A qualitative focus group study to identify the needs of survivors of stage II and III colorectal cancer
Authors: Ho Maria Y. , McBride Mary L. , Gotay Carolyn , Grunfeld Eva , Earle Craig C. , Relova Sharon , Tsonis Miranda , Ruan Jenny Y. , Chang Jennifer T. , Cheung Winson Y. 
Published: September 2015

AbstractBackgroundPrior survivorship research has largely focused on issues faced by survivors of childhood tumors, breast cancers, or hematologic malignancies. Relatively little is known about the needs of other prevalent survivor groups. Our aim was to identify the specific concerns of colorectal cancer (CRC) survivors in the key domains of physical functioning, psychological wellbeing, and social relationships.MethodsWe conducted focus groups with stage II and III CRC survivors who had completed their primary active anti‐cancer treatments. Patients were asked to describe how their diagnosis and treatment impacted their lives, to outline deficiencies in the care that they received, and to suggest ways of addressing any unmet needs. A content analysis was subsequently conducted to identify major themes.ResultsThirty CRC survivors participated in six focus groups. Individuals reported some degree of dissatisfaction with the amount and type of diagnostic and treatment information they received at their initial clinic visit. Distress from toxicities, such as peripheral neuropathy, was also common among the survivors. Similarly, the majority faced challenges adjusting to their lives and daily activities, especially in caring for their colostomy. Having survived CRC, many survivors expressed an interest in advocacy and health promotion of CRC.ConclusionsCRC survivors face many barriers after their cancer treatment. Issues with colostomy are unique to this survivor group. Interventions to improve CRC survivorship care should also incorporate opportunities for patient advocacy. Copyright © 2015 John Wiley & Sons, Ltd.
Sublattice engineering and voltage control of magnetism in triangular single and bi‐layer graphene quantum dots
Authors: Güçlü A. D. , Potasz P. , Hawrylak P. 
Published: September 2015

magnified imageWhen a Dirac electron is confined to a triangular graphene quantum dot with zigzag edges, its low‐energy spectrum collapses to a shell of degenerate states at the Fermi level leading to a magnetized edge. The shell degeneracy and the total magnetization are proportional to the edge size and can be made macroscopic. In this review, we start with a general discussion of magnetic properties of graphene structures and its relation to broken sublattice symmetry. Then, we discuss single electronic properties of single and bilayer triangular graphene quantum dots, focusing on the nature of edge states. Finally, we investigate the role of electronic correlations in determining the nature of ground state and excitation spectra of triangular graphene quantum dots as a function of dot size and filling fraction of the shell of zero‐energy states. The interactions are treated by a combination of tight‐binding, Hartree–Fock and configuration interaction methods. We show that the spin polarization of the triangular graphene quantum dots can be controlled through gating, i.e., by adding or removing electrons. In bilayer graphene dots, the relative filling of edge states in each layer and the magnetization can be tuned down to single localized spin using an external vertical electrical field. (© 2015 WILEY‐VCH Verlag GmbH &Co. KGaA, Weinheim)
Transplantation of Unique Subpopulation of Fibroblasts, Muse Cells, Ameliorates Experimental Stroke Possibly via Robust Neuronal Differentiation
Authors: Uchida Hiroki , Morita Takahiro , Niizuma Kuniyasu , Kushida Yoshihiro , Kuroda Yasumasa , Wakao Shohei , Sakata Hiroyuki , Matsuzaka Yoshiya , Mushiake Hajime , Tominaga Teiji , Borlongan Cesario V. , Dezawa Mari 
Published: September 2015

Abstract
Objective: Muse cells reside as pre-existing pluripotent-like stem cells within the fibroblasts, are nontumorigenic, exhibit differentiation capacity into triploblastic-lineage cells, and replenish lost cells when transplanted in injury models. Cell fate and function of human skin fibroblast-derived Muse cells were evaluated in a rat stroke model. Methods: Muse cells (30,000), collected by pluripotent surface marker stage-specific embryonic antigen-3, were injected stereotaxically into three deposits within the rat ischemic cortex at 2 days after transient middle cerebral artery occlusion, and the cells' biological effects were examined for more than 84 days. Results: Muse cells spontaneously and promptly committed to neural/neuronal-lineage cells when cocultured with stroke brain slices. Muse-transplanted stroke rats exhibited significant improvements in neurological and motor functions compared to control groups at chronic days 70 and 84, without a reduction in the infarct size. Muse cells survived in the host brain for up to 84 days and differentiated into NeuN (∼65%), MAP-2 (∼32%), calbindin (∼28%), and GST-π (∼25%)-positive cells in the cortex, but glial fibrillary acidic protein-positive cells were rare. Tumor formation was not observed. Muse cells integrated into the sensory-motor cortex, extended their neurites into cervical spinal cord, and displayed normalized hind limb somatosensory evoked potentials. Interpretation: Muse cells are unique from other stem cells in that they differentiate with high ratio into neuronal cells after integration with host brain microenvironment, possibly reconstructing the neuronal circuit to mitigate stroke symptoms. Human fibroblast-derived Muse cells pose as a novel source of transplantable stem cells, circumventing the need for gene manipulations, especially when contemplating autologous cell therapy for stroke.
Teachers' Adaptive Instruction Supporting Students' Literacy Learning
Authors: Vaughn Margaret , Parsons Seth A. , Gallagher Melissa A. , Branen Jeneille 
Published: September 2015

AbstractAdaptive teaching is an instructional approach where differences among learners are clearly recognized. For the last decade, our research team has studied literacy teachers' instructional adaptations in numerous classrooms in different regions of the United States. In this article, we share conclusions and insights from this longitudinal research. Specifically, we describe the characteristics of teachers who adapt their literacy instruction to support the individual needs of their students. Our aim is to support practicing teachers in their efforts to teach adaptively as they negotiate literacy instruction in today's diverse classrooms.
Longitudinal changes in maternal serum placental growth factor and soluble fms‐like tyrosine kinase‐1 in women at increased risk of pre‐eclampsia
Authors: Khalil A. , Maiz N. , Garcia‐Mandujano R. , Penco J. M. , Nicolaides K. H. 
Published: September 2015

ABSTRACTObjectivesTo investigate longitudinal changes in maternal serum levels of placental growth factor (PlGF) and soluble fms‐like tyrosine kinase‐1 (sFlt‐1) in pregnant women who develop pre‐eclampsia (PE) or gestational hypertension (GH).MethodsThis was a prospective longitudinal study in women with singleton pregnancies identified by screening at 11 + 0 to 13 + 6 weeks' gestation as being at high‐risk of PE. Blood samples were taken every 4 weeks until delivery. Values were compared in women who developed preterm PE (requiring delivery before 37 weeks' gestation), term PE or GH and those who remained normotensive.ResultsA total of 1069 samples were analyzed in 234 women, including 172 who remained normotensive, 18 who developed GH, 22 who developed preterm PE and 22 who developed term PE. In the preterm PE group, compared to the normotensive group, sFlt‐1 levels were significantly higher from 15 weeks' gestation onward and the difference increased with gestational age (P < 0.001). In the preterm PE group, compared to the normotensive group, PlGF levels were significantly lower from 11 weeks' gestation onward and the difference increased significantly with gestational age (P < 0.001). Similarly, in the term PE and GH groups, PlGF levels were lower from 13 and 27 weeks onward, respectively, and the differences increased significantly with gestational age (P < 0.001 for both groups). In the preterm PE group, compared to the normotensive group, the sFlt‐1/PlGF ratio was significantly higher from 11 weeks onward and the difference increased significantly with gestational age (P < 0.001). A random slope model provided a significantly better fit to the data than did a single‐level model for sFlt‐1 (likelihood ratio (LR) = 516; degrees of freedom (df) = 3; P < 0.001), PlGF (LR = 542; df = 3; P < 0.001) and the sFlt‐1/PlGF ratio (LR = 468; df = 3; P < 0.001).ConclusionRepeat measurements of the biochemical markers used in this study are likely to be better predictors of PE than are measurements at a single time point during pregnancy, as the differences between normotensive and hypertensive pregnancies increase with gestational age. In screening for preterm PE, maternal serum level of PlGF is a useful marker from the first trimester onward, while the level of sFlt‐1 is likely to have a predictive value from the second trimester onward. Copyright © 2015 ISUOG. Published by John Wiley & Sons Ltd.
Transcriptomic profiling of chemical exposure reveals roles of Yap1 in protecting yeast cells from oxidative and other types of stresses
Authors: Zhang Chao , Li Zhouquan , Zhang Xiaohua , Yuan Li , Dai Heping , Xiao Wei 
Published: September 2015

AbstractTranscriptomic profiles are generated by comparing wild‐type and the yeast yap1 mutant to various chemicals in an attempt to establish a correlation between this gene mutation and chemical exposure. Test chemicals include ClonNAT as a non‐genotoxic agent, methyl methanesulphonate (MMS) as an alkylating agent, tert‐butyl hydroperoxide (t‐BHP) as an oxidative agent and the mixture of t‐BHP and MMS to reflect complex natural exposure. Differentially expressed genes (DEGs) were identified and specific DEGs were obtained by excluding overlapping DEGs with the control group. In the MMS exposure group, deoxyribonucleotide biosynthetic processes were upregulated, while oxidation–reduction processes were downregulated. In the t‐BHP exposure group, metabolic processes were upregulated while peroxisome and ion transport pathways were downregulated. In the mixture exposure group, the proteasome pathway was upregulated, while the aerobic respiration was downregulated. Homologue analysis of DEGs related to human diseases showed that many of DEGs were linked to cancer, ageing and neuronal degeneration. These observations confirm that the yap1 mutant is more sensitive to chemicals than wild‐type cells and that the susceptible individuals carrying the YAP1‐like gene defect may enhance risk to chemical exposure. Hence, this study offers a novel approach to environmental risk assessment, based on the genetic backgrounds of susceptible individuals. Copyright © 2015 John Wiley & Sons, Ltd.
Three Isostructural 4‐Sulfophthalate‐Based Lanthanide Complexes: Syntheses, Crystal Structures, and Luminescent Properties
Authors: Shang Qiu , Li Yan , Yang En‐Cui , Zhao Xiao‐Jun 
Published: September 2015

AbstractThree lanthanide complexes with the ligand 4‐sulfophthalate (sp3–), [Ln(H2O)2(sp)]n [Ln = Dy (1), Tb (2), and Er (3)], were solvo‐/hydrothermally synthesized by changing the rare earth cations, and were characterized structurally and photophysically. Complexes 1–3 are isostructural, exhibiting a two‐dimensional layered structure with centrosymmetric dinuclear subunits infinitely extended by 4‐connected sp3– connectors. Photoluminescence spectra of 1–3 demonstrate that anionic sp3– ligand can serve as a functionalized chromophore to sensitize the luminescent emission of the lanthanide ion, suggesting that the sp3–‐involved lanthanide complexes can be used as novel optical materials.
Theoretically Predicted and Experimentally Observed Relaxation Pathways of two Heterodinuclear 3d‐4f Complexes
Authors: Bender Markus , Comba Peter , Demeshko Serhiy , Großhauser Michael , Müller Dennis , Wadepohl Hubert 
Published: September 2015

Abstract The dinucleating ligand (1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetrayl)‐tetrakis‐(methylene)‐tetrakis(2‐methoxy‐4‐methylphenol), H4L, is well preorganized with an N4O2 octahedral site for a divalent transition metal ion and an O4 site (phenolates and methoxo donors, completed by added pivalates and solvent molecules) for lanthanide ions. Two 3d‐4f complexes ([DyIII{NiII(μ‐H2L)}piv2(OH2)]ClO4 and [DyIII{CoII(μ‐H2L)}piv2(OH2)]ClO4) were prepared and fully characterized by X‐ray molecular structures and electronic properties determined by ac and dc SQUID magnetometry. While the NiII based complex shows single‐molecule magnetism (SMM), the CoII complex does not. With an extensive quantum‐chemical analysis, this is shown to be due to a misalignment of the single ion anisotropies in the latter complex, and reasons for this are discussed.
Ligand Exchange Processes in Abnormal N‐heterocyclic Carbene Rhodium Complexes
Authors: Krüger Anneke , Michaud Gaëlle , Dowling Aoife , Müller‐Bunz Helge , Albrecht Martin 
Published: September 2015

AbstractRhodium(III) complexes containing a mesoionic and strongly electron‐donating abnormal dicarbene ligand and a phosphine in a facial coordination mode and three ancillary iodide ligands undergo spontaneous solvolysis to give a cationic complex with an iodide in the outer coordination sphere. The availability of this non‐coordinating iodide promotes a halide exchange reaction and in chlorinated solvents such as chlorocyclohexane, chloroethyl benzene, 1,2‐dichloroethane, and benzyl chloride, the metal‐coordinated iodo ligands exchange for chlorides. Mechanistic investigations suggest that the role of the metal is to release the iodide anion, rather than being directly involved in the C–Cl bond activation. The release of the iodide from the metal coordination sphere is promoted by the strong donor ability of the abnormal dicarbene ligand.
Persisting Differences or Adaptation to German Fertility Patterns? First and Second Birth Behavior of the 1.5 and Second Generation Turkish Migrants in Germany
Authors: Krapf Sandra , Wolf Katharina 
Published: September 2015

AbstractIn this study, we use data of the German Mikrozensus to explore first and second birth behavior of migrants’ descendants. Whereas prior waves of the Mikrozensus only included respondents’ citizenship, in the survey years 2005 and 2009 also parental citizenship has been surveyed. This allows us to identify respondents’ migrant backgrounds, even if they have German citizenship. We distinguish those who migrated as children (1.5 generation) from those who were born to Turkish parents in Germany (second generation migrants). We compare both migrant generations to German non-migrants. Using discrete-time hazard models, our results show that 1.5 generation migrants have the highest probability of having a first and second birth, while German non-migrants have the lowest birth probabilities. The second generation lies in-between. This pattern also persists after taking the educational attainment of respondents into consideration. However, there seems to be an adaptation of highly educated second generation Turkish migrants to non-migrant Germans: we find no significant differences in the probability of having a first birth in the two groups. For second births, we do not find this pattern which might be related to the young age structure in the sample of second generation migrants.
Changes in the Determinants of Marriage Entry in Post-Reform Urban China
Authors: Yu Jia , Xie Yu 
Published: September 2015

AbstractUsing population intercensus and national survey data, we examine marriage timing in urban China spanning the past six decades. Descriptive analysis from the intercensus shows that marriage patterns have changed in China. Marriage age is delayed for both men and women, and prevalence of nonmarriage became as high as one-quarter for men in recent birth cohorts with very low levels of education. Capitalizing on individual-level survey data, we further explore the effects of demographic and socioeconomic determinants of entry into marriage in urban China over time. Our study yields three significant findings. First, the influence of economic prospects on marriage entry has significantly increased during the economic reform era for men. Second, the positive effect of working in the state-owned sector has substantially weakened. Third, educational attainment now has a negative effect on marriage timing for women. Taken together, these results suggest that the traditional hypergamy norm has persisted in China as an additional factor in the influences of economic resources on marriage formation.
Lost in transaction? The transfer effect of strategic consistency
Authors: Fehre Kerstin , Kronenwett Daniel , Lindstädt Hagen , Wolff Michael 
Published: September 2015

AbstractPrior empirical studies provide evidence that the learning-curve perspective from manufacturing settings is not directly applicable to strategic management settings. In the latter case learning relates to the quality rather than to the quantity of experience. Regarding the antecedents of organizational learning especially, there are still unanswered questions remaining; for example, the questions what kind of experience has a positive effect on performance and what kind of experience is more of a hindrance than a help. This becomes obvious when looking at acquisitions as examples of strategic management decisions. Results of prior empirical studies analyzing the relationship of acquisition experience and acquisition performance have been mixed. By introducing the concept of strategic consistency, we intend to facilitate a better understanding of the kind of experience necessary for organizational learning. Therefore, we measure the concordance and frequency of change in strategic actions. Employing a sample of 379 acquisition series, we find evidence for a positive transfer effect of strategic consistency within series and, therefore, a positive relationship between strategic consistency and acquisition performance.
Effects of functional remediation on neurocognitively impaired bipolar patients: enhancement of verbal memory
Authors: Bonnin C. M. , Reinares M. , Martínez-Arán A. , Balanzá-Martínez V. , Sole B. , Torrent C. , Tabarés-Seisdedos R. , García-Portilla M. P. , Ibáñez A. , Amann B. L. , Arango C. , Ayuso-Mateos J. L. , Crespo J. M. , González-Pinto A. , Colom F. , Vieta E. ,   The CIBERSAM Functional Remediation Group
Published: September 2015

BackgroundFunctional remediation is a novel intervention with demonstrated efficacy at improving functional outcome in euthymic bipolar patients. However, in a previous trial no significant changes in neurocognitive measures were detected. The objective of the present analysis was to test the efficacy of this therapy in the enhancement of neuropsychological functions in a subgroup of neurocognitively impaired bipolar patients.MethodA total of 188 out of 239 DSM-IV euthymic bipolar patients performing below two standard deviations from the mean of normative data in any neurocognitive test were included in this subanalysis. Repeated-measures analyses of variance were conducted to assess the impact of the treatment arms [functional remediation, psychoeducation, or treatment as usual (TAU)] on participants’ neurocognitive and functional outcomes in the subgroup of neurocognitively impaired patients.ResultsPatients receiving functional remediation (n = 56) showed an improvement on delayed free recall when compared with the TAU (n = 63) and psychoeducation (n = 69) groups as shown by the group × time interaction at 6-month follow-up [F2,158 = 3.37, degrees of freedom (df) = 2, p = 0.037]. However, Tukey post-hoc analyses revealed that functional remediation was only superior when compared with TAU (p = 0.04), but not with psychoeducation (p = 0.10). Finally, the patients in the functional remediation group also benefited from the treatment in terms of functional outcome (F2,158 = 4.26, df = 2, p = 0.016).ConclusionsFunctional remediation is effective at improving verbal memory and psychosocial functioning in a sample of neurocognitively impaired bipolar patients at 6-month follow-up. Neurocognitive enhancement may be one of the active ingredients of this novel intervention, and, specifically, verbal memory appears to be the most sensitive function that improves with functional remediation.
Norm antipreneurs and theorising resistance to normative change
Authors: BLOOMFIELD ALAN 
Published: September 2015

AbstractNorm dynamics studies typically accord a special status to norm entrepreneurs, actors who promote new global norms. But conceptually privileging these agents of change has meant the norm dynamics literature has become unbalanced and marred by case selection bias. Accordingly, an oppositional role – the ‘norm antipreneur’ – should be recognised to correct these problems. When the normative status quo in an issue-area isentrenched, a clear distinction can be drawn between the entrepreneurs and antipreneurs, because in these contexts the antipreneurs enjoy significant but under-appreciated tactical and strategic advantages. Recognising this enables the construction of a norm dynamics role-spectrum – a sort of ‘typology of roles’ – including ‘competitor entrepreneur’ and ‘creative resister’ in addition to the entrepreneur and antipreneur roles which actors might play in particular norm contestation contexts. Understanding these roles promises to improve analyses of the dynamic interactions between actors in particular norm contestation processes, thereby bringing greater overall balance to the norm dynamics literature.1