bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vertebral artery transposition for revascularization of the posterior circulation: a critical assessment of temporary and permanent complications and outcomes
Authors: Rangel-Castilla Leonardo , Kalani M. Yashar S. , Cronk Katherine , Zabramski Joseph M. , Russin Jonathan J. , Spetzler Robert F. 
Published: November 2014

OBJECT
Despite advances in medical management and endovascular therapies, including the introduction of statins, antiplatelet agents, and drug-eluting stents, some patients experience medically refractory vertebrobasilar insufficiency and may benefit from robust surgical revascularization. The aim of this study was to evaluate such patients after surgical revascularization, emphasizing long-term outcomes and rates of complications.

METHODS
The authors retrospectively identified 22 patients (5 women and 17 men) whose mean age was 69.1 years (range 48–81 years) who underwent revascularization of the posterior circulation via a proximal vertebral artery–carotid artery transposition between 2005 and 2013. The patients' conditions before surgery were clinically summarized, and long-term outcomes and complication rates after surgery were evaluated.

RESULTS
All the patients were symptomatic before surgery although they received the best medical therapy as defined by their primary care physician. Presenting symptoms consisted of stroke, transient ischemic attacks (TIAs), and/or findings attributable to posterior circulation hypoperfusion. There were no deaths associated with revascularization surgery. The postoperative complication rate was 45.5%, which included 3 cases of recurrent laryngeal nerve palsy, 1 case of thoracic duct injury, 2 cases of TIA, and 4 cases of Horner's syndrome. The thoracic duct injury was identified intraoperatively and ligated without sequelae, all the TIAs resolved within 24 hours of surgery, all 4 sympathetic plexus injuries resolved, and all but 1 of the recurrent laryngeal nerve palsies resolved, resulting in a 4.5% complication rate in a mean follow-up period of 8.8 months. All the patients had resolution of their presenting symptoms, and a single patient had symptomatic restenosis that required stenting and angioplasty, resulting in a restenosis rate of 4.5%.

CONCLUSIONS
Despite the optimization of medical therapies and lifestyle modifications, a select subset of patients with posterior vascular circulation insufficiency remains. In the authors' experience, vertebral artery–carotid artery transposition provides a surgical option with relatively low long-term complication and restenosis rates that are comparable or lower than those reported with endovascular treatment.
Caronary Artery Disease in Women
Authors: Neki NS 
Published: November 2014

Coronary artery disease (CAD) - which includes coronary atherosclerotic disease, myocardial infarction (MI), acute coronary syndrome and angina - is the most prevalent form of cardiovascular disease and is the largest subset of this mortality. Coronary artery disease (CAD) is a leading cause of death of women and men worldwide. CADs impact on women traditionally has been underappreciated due to higher rates at younger ages in men. Microvascular coronary disease disproportionately affects women. Women have unique risk factors for CAD, including those related to pregnancy and autoimmune disease.DOI: http://dx.doi.org/10.3329/jom.v15i2.20687 J MEDICINE 2014; 15 : 135-140
Disseminated Tuberculosis with Involvement of Appendix, Peritoneum and Right Knee Joint - A Case Report
Authors: Islam Mohammad Syedul , Azad Md. Abul Kalam , Mohammad Hanif , Islam Mohammad Mushahidul , Rahim Md. Abdur 
Published: November 2014

A 27 year old male presented with painful swelling of right knee joint for the last 6 months. Initially it was diagnosed as a case of reactive arthritis and was treated with NSAID with intraarticular steroids without significant improvement. Two months after the initial episode he again developed painful swelling of the right knee joint with severe abdominal pain and high grade fever. There was an ill defined ovoid mass in the right iliac fossa with generalized tenderness. ESR was raised and the ultrasonography revealed loculated ascites with appendicular lump. CT scan of the whole abdomen showed appendicular lump. FNAC from the lump showed tuberculosis. Joint fluid aspiration showed neutrophilic leucocytosis with the Total count 50,000/cmm. AFB was not found. So septic arthritis was diagnosed, but as the patient was not improving we send the patient to orthopedic department for synovial biopsy but they refused as it was septic. So a diagnosis of disseminated Tuberculosis was made with the involvement of right knee joint, appendix and peritoneum. He was put on anti TB and well responded.DOI: http://dx.doi.org/10.3329/jom.v15i2.20702 J MEDICINE 2014; 15 : 153-155
The Effect of Glycated Hemoglobin and Albumin-Corrected Glycated Serum Protein on Mortality in Diabetic Patients Receiving Continuous Peritoneal Dialysis
Authors: Peng Fenfen , Xia Xi , He Feng , Li Zhijian , Huang Fengxian , Yu Xueqing 
Published: November 2014

Objective To explore the effect of glycated hemoglobin (HbA1c) and albumin-corrected glycated serum proteins (Alb-GSP) on the mortality of diabetic patients receiving continuous peritoneal dialysis (PD). Methods In this single-center retrospective cohort study, incident diabetic PD patients from January 1, 2006, to December 31, 2010, were recruited, and followed up until December 31, 2011. The effect of HbA1c and Alb-GSP on mortality was evaluated by Cox proportional hazards models. Results A total of 200 patients (60% male, mean age 60.3 ± 10.6 years) with a mean follow-up of 29.0 months (range: 4.3 - 71.5 months) were recruited. Sixty-four patients died during the follow-up period, of whom 21 died of cardiovascular disease (CVD). Mean values for HbA1c, GSP and Alb-GSP were 6.7% (range: 4.1 - 12.5%), 202 μmol/L (range: 69 - 459 μmol/L), and 5.78 μmol/g (range: 2.16 - 14.98 μmol/g), respectively. The concentrations of GSP and Alb-GSP were closely correlated with HbA1c ( r = 0.41, p < 0.001 and r = 0.45, p < 0.001, respectively). In multivariate Cox proportional hazards models, patients with HbA1c ≥8% were associated with increased risk of all-cause mortality (hazard ratio [HR] = 2.29, 95% confidence interval [CI]: 1.06 - 4.96, p = 0.04), but no increased mortality in patients with 6.0% ≤ HbA1c ≤ 7.9%. Patients with Alb-GSP ≤ 4.50 μmol/g had increased all-cause and non-cardiovascular mortality (HR = 2.42, 95% CI: 1.13 - 5.19, p = 0.02; and HR = 2.98, 95% CI: 1.05 - 8.48, p = 0.04 respectively). Conclusions Increased HbA1c and decreased Alb-GSP may be associated with poorer survival in diabetic PD patients, with a non-significant trend observed for poorer survival with the highest level of Alb-GSP.
Genetic Polymorphisms and Peritoneal Membrane Function
Authors: Siddique Imad , Brimble K. Scott , Walkin Louise , Summers Angela , Brenchley Paul , Herrick Sarah , Margetts Peter J. 
Published: November 2014

Background Outcomes for peritoneal dialysis (PD) patients are affected by the characteristics of the peritoneal membrane, which may be determined by genetic variants. We carried out a systematic review of the literature to identify studies which assessed the association between genetic polymorphisms, peritoneal membrane solute transport, and clinical outcomes for PD patients. Methods The National Library of Medicine was searched using a variety of strategies. Studies which met our inclusion criteria were reviewed and data abstracted. Our outcomes of interest included: high transport status peritoneal membrane, risk for peritonitis, encapsulating peritoneal sclerosis (EPS), patient and technique survival. We combined data from studies which evaluated the same genetic polymorphism and the same outcome. Results We evaluated 18 relevant studies. All studies used a candidate gene approach. Gene polymorphisms in the interleukin (IL)-6 gene were associated with peritoneal membrane solute transport in several studies in different ethnic populations. Associations with solute transport and polymorphisms in endothelial nitric oxide synthase and receptor for advanced glycation end product genes were also identified. There was evidence of a genetic predisposition for peritonitis found in 2 studies, and for EPS in 1 study. Survival was found to be associated with a polymorphism in vascular endothelial growth factor and technique failure was associated with a polymorphism in the IL-1 receptor antagonist. Conclusions There is evidence that characteristics of the peritoneal membrane and clinical outcomes for PD patients have genetic determinants. The most consistent association was between IL-6 gene polymorphisms and peritoneal membrane solute transport.
Near-Infrared Light Therapy to Attenuate Strength Loss After Strenuous Resistance Exercise
Authors: Larkin-Kaiser Kelly A. , Christou Evangelos , Tillman Mark , George Steven , Borsa Paul A. 
Published: November 2014

Context:
Near-infrared (NIR) light therapy is purported to act as an ergogenic aid by enhancing the contractile function of skeletal muscle. Improving muscle function is a new avenue for research in the area of laser therapy; however, very few researchers have examined the ergogenic effects of NIR light therapy and the influence it may have on the recovery process during rehabilitation.

Objective:
To evaluate the ergogenic effect of NIR light therapy on skeletal muscle function.

Design:
Crossover study.

Setting:
Controlled laboratory.

Patients or Other Participants:
Thirty-nine healthy men (n = 21) and women (n = 18; age = 20.0 ± 0.2 years, height = 169 ± 2 cm, mass = 68.4 ± 1.8 kg, body mass index = 23.8 ± 0.4 kg/m2).

Intervention(s):
Each participant received active and sham treatments on the biceps brachii muscle on 2 separate days. The order of treatment was randomized. A class 4 laser with a cumulative dose of 360 J was used for the active treatment. After receiving the treatment on each day, participants completed an elbow-flexion resistance-exercise protocol.

Main Outcome Measure(s):
The dependent variables were elbow range of motion, muscle point tenderness, and strength (peak torque). Analysis of variance with repeated measures was used to assess changes in these measures between treatments at baseline and at follow-up, 48 hours postexercise. Additionally, immediate strength loss postexercise was compared between treatments using a paired t test.

Results:
Preexercise to postexercise strength loss for the active laser treatment, although small, was less than with the sham treatment (P = .05).

Conclusions:
Applied to skeletal muscle before resistance exercise, NIR light therapy effectively attenuated strength loss. Therefore, NIR light therapy may be a beneficial, noninvasive modality for improving muscle function during rehabilitation after musculoskeletal injury. However, future studies using higher treatment doses are warranted.
Where there is no morphine: The challenge and hope of palliative care delivery in Tanzania
Authors: Hartwig Kristopher , Dean Mervyn , Hartwig Kari , Mmbando Paul Z. , Sayed Abduraoof , De Vries Elma 
Published: November 2014

Background: In Tanzania, a country of 42 million, access to oral morphine is rare.Aim: To demonstrate the effectiveness of palliative care teams in reducing patients’ pain and in increasing other positive life qualities in the absence of morphine; and to document the psychological burden experienced by their clinical providers, trained in morphine delivery, as they observed their patients suffering and in extreme pain.Setting: One hundred and forty-fie cancer patients were included from 13 rural hospitals spread across Tanzania.Method: A mixed method study beginning with a retrospective quantitative analysis of cancer patients who were administered the APCA African POS tool four times. Bivariate analyses of the scores at time one and four were compared across the domains. The qualitative arm included an analysis of interviews with six nurses, each with more than fie years’ palliative care experience and no access to strong opioids.Results: Patients and their family caregivers identifid statistically signifiant (p < 0.001) improvements in all of the domains. Thematic analysis of nurse interviews described the patient and family benefis from palliative care but also their great distress when ‘bad cases’ arose who would likely benefi only from oral morphine.Conclusion: People living with chronic cancer-related pain who receive palliative care experience profound physical, spiritual and emotional benefis even without oral morphine. These results demonstrate the need for continued advocacy to increase the availability of oral morphine in these settings in addition to palliative care services.
The Effect of Erythropoietin on Progesterone Levels during Ischemia Reperfusion Injury in Rats
Authors: Tsompos Constantinos , Panoulis Constantinos , Toutouzas Konstantinos , Zografos George , Papalois Apostolos 
Published: November 2014

ABSTRACT
The aim of this experiment was to study the effects of erythropoietin on rat model, particularly in ischemia reperfusion protocol. The beneficial or other effects of that molecule were studied estimating the mean blood progesterone levels.

Materials and methods
Forty rats were used of mean weight 247.7 gm. Progesterone levels were measured 60 minutes after reperfusion for groups A and C and 120 minutes after reperfusion for groups B and D. Groups A and B without the drug but C and D with erythropoietin administration.

Results
That erythropoietin administration nonsignificantly increased the progesterone levels by 4.235501 nmol/l (—13.07804 nmol/l — 21.54904 nmol/l) (p = 0.6233). This finding was in accordance with the results of paired t-test (p = 0.6724). Reperfusion time nonsignificantly decreased the progesterone levels by —0.2034999 nmol/l (—17.5727 nmol/l — 17.1657 nmol/l) (p = 0.9812), also in accordance with paired t-test (p = 0.9821). However, erythropoietin administration and reperfusion time together nonsignificantly increased the progesterone levels by 1.713364 nmol/l (—8.74561 nmol/l — 12.17234 nmol/l) (p = 0.7420).

Conclusion
Results of this study indicate that Epo decreases the predicted progesterone levels by 4.7 to 8.8%. This decreasing effect although non-significant is reinforced along time. Perhaps, a longer study time than 2 hours may provide clearer and significant effect.

How to cite this article
Tsompos C, Panoulis C, Toutouzas K, Zografos G, Papalois A. The Effect of Erythropoietin on Progesterone Levels during Ischemia Reperfusion Injury in Rats. J South Asian Feder Obst Gynae 2014;6(2):65-70.
Seasonal Trends in the Occurrence of Eclampsia
Authors: Malik Ahmad , Kausar Shaheen , Bashir Alia , Qureshi Mamoon Akbar 
Published: November 2014

ABSTRACTBackgroundPreeclampsia and eclampsia are major obstetric complications with unclear etiologies. Understanding the exact association with different weather patterns may help us in understanding what factors may be involved in triggering these events. Lower temperature, higher humidity and lower barometric pressure are linked to eclampsia.ObjectiveTo know the relation between variations of weather and incidence of eclampsia in patients presenting in, Jinnah Hospital, Lahore.Materials and methodsTotal number of deliveries and patients presenting with eclampsia were recorded from January 2008 to December 2012. Meteorological data was acquired from the regional meteorological center recording the monthly average temperature, humidity, barometric pressure and rainfall during the study period. The incidence of eclampsia and the seasonal trend were analyzed for Maximum (MMM) temperature, humidity at 5 pm, 5 pm atmospheric pressure (ATM) and rainfall.Study designCross sectional studyStudy settingGyne Unit 2, Jinnah Hospital, LahoreResultsOver a 60-month period, a total of 31,331 deliveries were recorded, of which 579 patients developed eclampsia (1.85%). There was a statistically significant Pearson's correlation coefficient, the incidence of eclampsia was found to increase with MMM 5 pm temperature (0.516, p < 0.05) and rainfall (0.427, p < 0.05) and 5 pm ATM atmospheric pressure (—0.501, p < 0.05). No significant correlation was found with humidity (0.093, p > 0.05).ConclusionIncidence of eclampsia has direct linear relationship with increased temperature and rainfall and inverse relationship with 5 pm atmospheric pressure. The humidity had no apparent effect.How to cite this articleKausar S, Bashir A, Malik A, Qureshi MA. Seasonal Trends in the Occurrence of Eclampsia. J South Asian Feder Obst Gynae 2014;6(2):83-87.
Vaginal Leiomyoma: A Rare Presentation
Authors: Singh Richa , Yadav Poonam 
Published: November 2014

ABSTRACT
Vaginal leiomyoma is a rare clinical entity with varied clinical presentation. Symptomatology ranges from being asymptomatic to symptoms like dyspareunia, pressure symptoms and discharge per vaginum. These leiomyomas if situated in lower half of vagina may mimic vaginal cysts or uterine prolapse and in upper half of vagina may be confused with bladder malignancy. Surgical excision followed by histopathology is the management for establishing the diagnosis and ruling out malignancy.

How to cite this article
Singh R, Yadav P, Kaur H. Vaginal Leiomyoma: A Rare Presentation. J South Asian Feder Obst Gynae 2014;6(2):112-113.
Malignant Brenner Tumor of Ovary
Authors: Joshi Shikha , Ubeja Prabhjot 
Published: November 2014

ABSTRACT

Introduction
Ovarian carcinoma remains the most lethal disease of the female reproductive tract and most difficult to diagnose early. Brenner tumor of ovary is a relatively uncommon neoplasm constituting 1.4 to 2.5% of all ovarian tumors. In vast majority of cases, these tumor are benign, only 2.5% being malignant.

Case Report
A 46 years old parous menopausal female presented with complains of pain in abdomen since 2 months and lump in right iliac region. Per abdomen examination showed irregular mass of variable consistency with 16 to 18 weeks gravid uterus size arising from pelvis. On per vaginum examination, firm to hard mass was felt in the posterior and lateral fornices exact size of which could not be determined. Per rectal examination revealed hard nodules in Pouch of Douglas (POD). Ovarian cytoreduction surgery was performed. Omentectomy was performed. Histopathology showed malignant Brenner tumor (transitional cell carcinoma).

Conclusion
Although Brenner tumors are rare and the majority of them are benign, the correct histological diagnosis with identification of the small proportion of malignant tumors allows the extent of the operation to be needed.

How to cite this article
Hariharan C, Joshi S, Ubeja P. Malignant Brenner Tumor of Ovary. J South Asian Feder Obst Gynae 2014;6(2):126-128.
A Simple Method for Patients Palatal Rugae Duplication in Complete Dentures
Authors: Naqvi Sana , Dange Shankar Pandhrinath , Khalikar Smita Arun 
Published: November 2014

ABSTRACT
A complete denture should fulfill four basic requirements: esthetics, phonetics, efficiency and comfort. As propagated by Terrell,1 dentures should be an aid rather than a hindrance to good speech. Palatal rugae play a vital role in the production of palato lingual sounds. A simple inexpensive method for duplication of patient's palatal rugae is described in this article.

How to cite this article
Naqvi S, Dange SP, Khalikar SA. A Simple Method for Patients Palatal Rugae Duplication in Com- plete Dentures. Int J Prosthodont Restor Dent 2014;4(2):46-47.
Esthetic and Functional Rehabilitation of a Patient with Abrasion, Attrition, and Missing Teeth
Authors: Kulkarni Rahul S 
Published: November 2014

ABSTRACT
The loss of tooth substance due to attrition and abrasion may lead to sensitivity to hot and cold, compromised esthetics, loss of anterior guidance and decreased masticatory efficiency. This case report describes the oral rehabilitation of a patient with abrasion, attrition and missing teeth. Treatment consisted of endodontic treatments of multiple teeth followed by their full coverage restorations, and fixed partial dentures for replacement of missing teeth. Esthetic and functional rehabilitation resulted in patient satisfaction, and no complications were noted related to the treatment after 1 year.

How to cite this article
Kulkarni RS. Esthetic and Functional Rehabilitation of a Patient with Abrasion, Attrition, and Missing Teeth. Int J Prosthodont Restor Dent 2014;4(2):52-55.
Transesophageal Echocardiography in a Case of Dextro- Transposition of Great Arteries with Regressed Left Ventricle
Authors: Kiran Usha , Narula Jitin , Makhija Neeti , Singh Sarvesh Pal 
Published: November 2014

ABSTRACTPatients with dextro-transposition of the great arteries (d-TGA) with an intact ventricular septum (IVS) beyond 21 days of age may develop left ventricular (LV) regression. Perioperative echocardiography-guided assessment of LV for signs of regression is crucial in decision-making for definitive corrective surgery, namely arterial switch operation (ASO), as a regressed LV may not be capable of sustaining the load of systemic circulation. We hereby present transesophageal echocardiography (TEE) findings in a child with d-TGA and regressed LV where decision to perform a primary ASO with integrated extracorporeal membrane oxygenation (ECMO)- cardiopulmonary bypass (CPB) circuit was made. Use of ECMO was planned as a standby technique in the event of LV failure. ECMO was eventually used as the LV was unable to sustain the load of systemic circulation after ASO.How to cite this articleMakhija N, Singh SP, Narula J, Choudhury A, Kiran U. Transesophageal Echocardiography in a Case of Dextro-Transposition of Great Arteries with Regressed Left Ventricle. J Perioper Echocardiogr 2014;2(2):71-74.
Perspective: Transforming medical education through informatics
Authors: Triola Marc 
Published: November 2014

In the United States and around the world there have been massive changes in the way that health care is evolving – the way that we deliver care, the models of care, the concept of the interprofessional team, the system of care as a network that extends increasingly outside of the hospital much more than in, population and global care, and evidence-based medicine. We are challenged to keep up with our education system's “adaptivity” in this dynamic environment.
At the same time the disruptive effects of technological advances are dramatically accelerating and will challenge the way that healthcare providers, schools teaching young doctors, and patients themselves will experience and understand clinical data. There are emerging technologies that will be implemented around the world, almost instantly; whereas, these analogs in the past took decades to spread globally.
Monocyte subsets in atherosclerosis
Authors: Heine G. H. , Hristov M. 
Published: November 2014

SummaryEndothelial dysfunction and chronic inflammation of the arterial wall continuously drive the development of atherosclerotic lesions. Monocytes, as cells of the innate immunity, are particularly involved in this process. In the last decade, heterogeneity of circulating monocytes has widely been acknowledged, and a recent consensus nomenclature subdivides classical, intermediate and nonclassical monocytes. Accumulating experimental and clinical data suggest a differential, subsetspecific contribution of monocytes to the pathology of atherosclerosis.This review summarizes recent key findings on human and mouse monocyte subpopulations, specifically highlighting their phenotype, functional characteristics and mechanisms of recruitment at homeostatic conditions, in atherosclerotic vascular disease, and after acute myocardial infarction.