bluuebunny/crossref_metadata_2025_split huggingface dataset:
Son-of-God traditions in the Synoptic Gospels: Ferdinand Hahn's diachronic perspective
Authors: Dreyer Yolanda 
Published: June 2013

This study makes use of Ferdinand Hahn's insights (with Son of God as case study) to indicate how the naming of Jesus developed in stages. It is shown that the name Son of God was not used by Jesus. It functioned within the context of the cultic activities of early Christianity, was taken over from the surrounding religious, political and cultural world while its referential meaning shifted in the various layers. Hahn focuses on the multi-stage development of the Jesus tradition from an Aramaic "Judaism", through a Hellenistic "Judaism" to a Gaeco-Roman stage. First the possible historical origins of the title Son of God are discussed, after which Hahn's view is taken into consideration.
Die probleem van hoe die Verkondiger die Verkondigde geword het: Die bydrae van Rudolf Bultmann
Authors: Van Wyk D. J.C. 
Published: June 2013

The problem of how the Proclaimer became the Proclaimed: The contribution of Rudolf Bultmann. The transmission of Jesus' message by the earliest Christian communities evolved into he synoptic tradition. In this process, the proclamation of Jesus was expanded. According to RudolJ Bultmann, the question of how the Proclaim er (the historical Jesus) became the Proclaimed (the kerygmatic Jesus) is a decisive issue for believers' understanding of the New Testament This article aims to demonstrate aspects of Bultmann's construction of the message of the historical Jesus. It focuses on Bultmann's understanding of Jesus' vision of the Kingdom of God. It also discusses Bultmann's view of the relationship between faith and history. It concludes by comparing Bultmann's insights with those of present-day historical Jesus researchers
“You Turn Me into Nothing”: Reformation of Queenship on the Jacobean Stage
Authors: Moore Gaywyn 
Published: June 2013

ABSTRACT
Henry VIII's divorce of Katherine of Aragon and execution of Anne Boleyn mark the beginning of the English Reformation and a substantial alteration of the queen consort role. Early modern plays that feature Henry VIII's queens, such as Samuel Rowley's When You See Me, You Know Me and William Shakespeare and John Fletcher's King Henry VIII, focus on the transition from a medieval to an early modern notion of queenship and represent the dismantled position of the queen consort in early sixteenth-century England. They also highlight the unstable and reduced position that future English queens would inherit.
The Possibility of Justice: Bárbara Colio's Antigone in Usted está aquí
Authors: Vargas Margarita 
Published: June 2013

ABSTRACT
In her play, Usted está aquí (You Are Here, 2009) Bárbara Colio creates an Antigone-type character to address questions of justice and social responsibility. The play is based on the story of Isabel Miranda de Wallace, who relentlessly sought justice for her son, Hugo Alberto Wallace Miranda, who was kidnapped and killed in Mexico City in 2005. The return to antiquity draws attention to the perennial existence of power struggles and violence, but the references to a twenty-first-century Mexican reality and the use of metatheatrical devices reveal Colio's conviction that through activism justice can be achieved.
3D RECONSTRUCTION AND ANALYSIS OF THE FRAGMENTED GRAINS IN A COMPOSITE MATERIAL
Authors: Gillibert Luc , Jeulin Dominique 
Published: June 2013

X-ray microtomography from solid propellant allows studying the microstructure of fragmented grains in damaged samples. A new reconstruction algorithm of fragmented grains for 3D images is introduced. Based on a watershed transform of a morphological closing of the input image, the algorithm can be used with different sets of markers. Two of them are compared. After the grain reconstruction, a multiscale segmentation algorithm is used to extract each fragment of the damaged grains. This allows an original quantitative study of the fragmentation of each grain in 3D. Experimental results on X-ray microtomographic images of a solid propellant fragmented under compression are presented and validated.
Comparison Between 1-Needle Technique Versus 2-Needle Technique for Bone Marrow Aspiration and Biopsy Procedures
Authors: Al-Ibraheemi Alyaa , Pham Tiffany , Chen Lei , Syklawer Erica , Quesada Andres , Wahed Amer , Nedelcu Elena , Nguyen Andy N. D. 
Published: June 2013

Context.—Bone marrow examination is essential for diagnosis and staging of hematologic disorders. Traditionally, the bone marrow biopsy and aspirate are obtained with 2 needles at 2 separate sites. This approach is associated with significant discomfort, procedural time, and occasionally, morbidity. Although previous observations had suggested that a single-needle technique at one site is a simpler and less-painful procedure, there had been concern that the 1-needle technique may yield a suboptimal biopsy for diagnosis.
Objective.—To conduct a systematic comparison of multiple parameters of bone marrow biopsy specimens obtained by the traditional 2-needle technique versus the 1-needle technique for bone marrow collection.
Design.—We retrospectively evaluated 20 biopsy specimens obtained by each of the 2 mentioned techniques by comparing the morphologic quality of the biopsy, biopsy length, and biopsy cellularity.
Results.—We found that the 1-needle technique yielded an adequate biopsy for diagnosis. The measured parameters of the samples obtained by the 1-needle versus 2-needle techniques were similar.
Conclusion.—This study suggests that the 1-needle technique may be preferred for bone marrow aspirate and biopsy.
Prevalence of Terminal Duct Lobular Units and Frequency of Neoplastic Involvement of the Nipple in Mastectomy
Authors: Kryvenko Oleksandr N. , Yoon Ji Yoon , Chitale Dhananjay A. , Lee Min W. 
Published: June 2013

Context.—Breast cancer treatment has greatly evolved from radical mastectomy to more cosmetically acceptable and less-debilitating surgeries. Nipple-sparing mastectomy is increasingly done for both cancer treatment and risk reduction. The frequency of terminal duct lobular units (TDLUs) and occult neoplastic epithelial proliferation in grossly/clinically unremarkable nipples (GUNs) is not well investigated.
Objective.—To describe frequency of TDLUs and occult and overt neoplastic nipple involvement.
Design.—Nipples from 105 consecutive specimens (90 therapeutic, 15 prophylactic) were studied. Sixty-five nipples were entirely submitted to evaluate frequency of TDLUs; the rest had 1 vertical section submitted.
Results.—Terminal duct lobular unit was seen in 17 GUNs (26%). Six had TDLU in the base, 6 had it in the papilla, and 5 in both. Four GUNs showed lobular carcinoma in situ (1), Paget disease (1), and pagetoid extension of underlying malignancy (2). Grossly/clinically abnormal nipples had Paget disease (2), lymphovascular invasion (2), invasive carcinoma (4), and pagetoid extension (5). Involved nipples were closer to tumor (mean, 1.1 versus 3.2 cm, P &lt; .001), had larger underlying tumors (mean, 4.3 versus 2.6 cm, P = .03) and of higher grade (P = .04), and more often had lymph node metastases (91% versus 44%, P = .007). No pathologic abnormalities were found in prophylactic mastectomy nipples.
Conclusions.—Terminal duct lobular units were seen in 26% of nipples. They were frequently seen in the nipple papilla. Occult neoplastic epithelial proliferation was seen in 5% of grossly/clinically unremarkable therapeutic mastectomy nipples. Pagetoid extension was the dominant spread of underlying malignancy. Overall, the nipple was more often involved by larger and higher-grade tumors located closer to the nipple. All prophylactic mastectomies had unremarkable nipples. These findings should be considered while selecting patients for nipple-sparing mastectomy.
Direct Thrombin Inhibitors and Factor Xa Inhibitors Can Influence the Diluted Prothrombin Time Used as the Initial Screen for Lupus Anticoagulant
Authors: Olah Zsolt , Szarvas Mariann , Bereczky Zsuzsanna , Kerenyi Adrienne , Kappelmayer Janos , Boda Zoltan 
Published: June 2013

Context.—Lupus anticoagulant (LA) is a heterogeneous group of antiphospholipid antibodies. Among others, diluted prothrombin time (dPT) is a sensitive screening test for LA; however, the interpretation of LA tests is difficult in patients treated with anticoagulants. The effect of different types of anticoagulants on the result of LA tests, particularly on dPT, has not been studied extensively.Objective.—To determine whether the direct thrombin inhibitors lepirudin and argatroban and the predominantly factor Xa inhibitors enoxaparin, danaparoid, and fondaparinux could interfere with LA screening based on dPT.Design.—Each drug was added to normal and LA-positive plasmas in clinically relevant concentrations. Each sample was tested for dPT. Samples with factor Xa inhibitors were investigated before and after addition of heparinase. Mixing and confirmatory tests for LA were not performed.Results.—In the presence of lepirudin or argatroban, dPT increased notably and the dPT ratio exceeded the cutoff value even at subtherapeutic concentrations resulting in false positivity. With increasing factor Xa inhibitor concentrations, a linear increase of dPT ratios and false-positive results were also demonstrated. Although heparinase could almost completely neutralize the anti-Xa effect of all investigated factor Xa inhibitors, dPT ratio returned to the basal level only in case of enoxaparin.Conclusions.—Here we provide evidence that both the direct thrombin and indirect factor Xa inhibitors influence dPT assay for LA, causing false positivity. This should be considered when interpreting LA results during anticoagulant therapy. However, dPT seems to be a reliable test for LA screening under enoxaparin therapy after neutralization by heparinase.
Prevalence and Types of Misrepresentation of Publication Record by Pathology Residency Applicants
Authors: Kaley Jennifer Raible , Bornhorst Joshua , Wiggins Michael , Yared Marwan 
Published: June 2013

Context.—Publication misrepresentation among residency applicants has been demonstrated in various specialties. This study examines the prevalence of publication misrepresentation among US-trained and non–US-trained pathology residency applicants.
Objective.—To determine the prevalence of publication misrepresentation in the pathology applicant pool at our institution, to compare the rates of misrepresentation among US-trained and non–US-trained applicants, and to compare results to published results from other medical specialties.
Design.—All peer-reviewed journal articles reported on applications to our program in 2010 and 2011 were examined for veracity. Applications from current or past trainees and applications with unverifiable manuscripts were excluded. The type of misrepresentation and the country in which the applicant trained were recorded.
Results.—Seven hundred applications were reviewed. Of 319 (46%) reported publications, 25 were from US graduates (8%) and 294 (92%) were from non-US graduates. Eighty-six applications were excluded owing to unverifiable manuscripts. Publication misrepresentations were found in 42 (18%) of the remaining 233 applications. The most common misrepresentations were omission of authors (69%), nonauthorship (14%), and self-promotion on the author list (12%). A significantly higher percentage of foreign medical graduates listed publications (P &lt; .001). The misrepresentation rate by foreign graduates (19%) did not differ significantly from that of US-trained graduates (13%) (P = .45).
Conclusions.—Publication misrepresentation was present among pathology residency applicants. Similar rates were seen among US and non-US applicants. Percentages of misrepresentation among applicants to our pathology program and applicants to other medical specialties (18% and 17%, respectively) were comparable.
A Multiplex Technology Platform for the Rapid Analysis of Clinically Actionable Genetic Alterations and Validation for BRAF p.V600E Detection in 1549 Cytologic and Histologic Specimens
Authors: Smith David L. , Lamy Aude , Beaudenon-Huibregtse Sylvie , Sesboüé Richard , Laosinchai-Wolf Walairat , Sabourin Jean-Christophe , Labourier Emmanuel 
Published: June 2013

Context.—Current clinicopathologic assessment of malignant neoplastic diseases entails the analysis of specific genetic alterations that provide diagnostic, prognostic, or therapy-determining information.Objective.—To develop and validate a robust molecular method to detect clinically relevant mutations in various tissue types and anatomic pathology specimens.Design.—Genes of interest were amplified by multiplex polymerase chain reaction and sequence variants identified by liquid bead array cytometry. The BRAF assay was fully characterized by using plasmids and genomic DNA extracted from cell lines, metastatic colorectal cancer formalin-fixed, paraffin-embedded (FFPE) tissues, and thyroid nodule fine-needle aspirates.Results.—Qualitative multiplex assays for 22 different mutations in the BRAF, HRAS, KRAS, NRAS, or EGFR genes were established. The high signal-to-noise ratio of the technology enabled reproducible detection of BRAF c.1799T&gt;A (p.V600E) at 0.5% mutant allele in 20 ng of genomic DNA. Precision studies with multiple operators and instruments showed very high repeatability and reproducibility with 100% (98.7%–100%) qualitative agreement among 292 individual measures in 38 runs. Evaluation of 1549 representative pathologic specimens in 2 laboratories relative to independent reference methods resulted in 99.0% (97.6%–99.6%) agreement for colorectal FFPE tissues (n = 416) and 98.9% (98.2%–99.4%) for thyroid fine-needle aspiration specimens (n = 1133) with an overall diagnostic odds ratio of 10 856 (2451–48 078).Conclusions.—The multiplex assay system is a sensitive and reliable method to detect BRAF c.1799T&gt;A mutation in colorectal and thyroid lesions. This optimized technology platform is suitable for the rapid analysis of clinically actionable genetic alterations in cytologic and histologic specimens.
Photo‐Activatable Surfaces for Cell Migration Assays
Authors: Salierno Marcelo J. , García Andrés J. , del Campo Aránzazu 
Published: June 2013

AbstractA simple material platform for advanced cell migration studies is presented. It relies on surfaces modified with photo‐activatable adhesion peptides and two light exposure steps to independently trigger attachment and migration. The light‐controlled exposure of adhesive ligands allows precise and selective control over integrin‐mediated adhesion and migration events, including their dynamic variation. By using a microscope‐coupled scanning laser, user‐defined geometry, size and composition of the adhesion and migration spaces are possible and simply defined by the laser scanning parameters. Time lapse and high resolution microscopy are possible during the complete process. The miniaturization capabilities of this assay also allow (i) parallel or sequential migration experiments and controls on the same view field of the microscope, (ii) migration studies in confined and unconventional geometries or (iii) activation of migration spaces at subcellular resolution, all of these with minimum material and time consumption. The photo‐activatable surfaces will allow studies of the dynamics of integrin‐dependent migration processes with unprecedented flexibility, multiplexing, reproducibility, and spatiotemporal resolution.
Surface Coatings that Promote Rapid Release of Peptide‐Based AgrC Inhibitors for Attenuation of Quorum Sensing in Staphylococcus aureus
Authors: Broderick Adam H. , Stacy Danielle M. , Tal‐Gan Yftah , Kratochvil Michael J. , Blackwell Helen E. , Lynn David M. 
Published: June 2013

AbstractStaphylococcus aureus is a major human pathogen responsible for a variety of life‐threatening infections. The pathogenicity of this organism is attributed to its ability to produce a range of virulence factors and toxins, including the superantigen toxic shock syndrome toxin‐1 (TSST‐1). While many S. aureus infections can be treated using conventional antibiotics, strains resistant to these bactericidal agents have emerged. Approaches that suppress pathogenicity through mechanisms that are nonbactericidal (i.e., antivirulence approaches) could provide new options for treating infections, including those caused by resistant strains. Here, we report a nonbactericidal approach to suppressing pathogenicity based on the release of macrocyclic peptides (1 and 2) that inhibit the agr quorum sensing (QS) circuit in group‐III S. aureus. It is demonstrated that these peptides can be immobilized on planar and complex objects (on glass slides, nonwoven meshes, or within absorbent tampons) using the rapidly dissolving polymer carboxymethylcellulose (CMC). Peptide‐loaded CMC films released peptide rapidly (<5 min) and promoted strong (>95%) inhibition of the agr QS circuit without inducing cell death when incubated in the presence of a group‐III S. aureus gfp‐reporter strain. Peptide 1 is among the most potent inhibitors of QS in S. aureus reported to date, and the group‐III QS circuit regulates production of TSST‐1, the primary cause of toxic shock syndrome (TSS). These results thus suggest approaches to treat the outer covers of tampons, wound dressings, or other objects to suppress toxin production and reduce the severity of TSS in clinical and personal care contexts. Because peptide 1 also inhibits QS in S. aureus groups‐I, ‐II, and ‐IV, this approach could also provide a pathway for attenuation of QS and associated virulence phenotypes in a broader range of contexts.
Development and Performance of MnFeCrO4‐Based Electrodes for Solid Oxide Fuel Cells
Authors: Stefan Elena , Tsekouras George , Irvine John T.S. 
Published: June 2013

AbstractImportant advances have been made in SOFC development utilizing a ceramic framework based upon yttria zirconia (YSZ) electrolytes supported upon porous YSZ electrode skeletons. This ceramic framework is sintered at high temperatures with subsequent impregnation and low temperature processing of the active electrode materials. Here we seek to develop this impregnated electrode concept by investigating a novel scaffold material similar to the main corrosion product of ferritic stainless steel. The chromium rich spinel (MnFeCrO4) was used as an electrode support material, either alone or impregnated with (La0.75Sr0.25)0.97Cr0.5Mn0.5O3‐δ, La0.8Sr0.2FeO3‐δ, Ce0.9Gd0.1O2‐δ, CeO2 and/or Pd. In these initial studies it was found that all of the impregnated phases adhere very well to the spinel and considerably enhance performance and stability to a level sufficient for SOFC applications.
Severe infantile leigh syndrome associated with a rare mitochondrial ND6 mutation, m.14487T>C
Authors: Tarnopolsky Mark , Meaney Brandon , Robinson Brian , Sheldon Katherine , Boles Richard G. 
Published: June 2013

AbstractWe describe a case of severe infantile‐onset complex I deficiency in association with an apparent de novo near‐homoplasmic mutation (m.14487T>C) in the mitochondrial ND6 gene, which was previously associated with Leigh syndrome and other neurological disorders. The mutation was near‐homoplasmic in muscle by NextGen sequencing (99.4% mutant), homoplasmic in muscle by Sanger sequencing, and it was associated with a severe complex I deficiency in both muscle and fibroblasts. This supports previous data regarding Leigh syndrome being on the severe end of a phenotypic spectrum including progressive myoclonic epilepsy, childhood‐onset dystonia, bilateral striatal necrosis, and optic atrophy, depending on the proportion of mutant heteroplasmy. While the mother in all previously reported cases was heteroplasmic, the mother and brother of this case were homoplasmic for the wild‐type, m.14487T. Importantly, the current data demonstrate the potential for cases of mutations that were previously reported to be homoplasmic by Sanger sequencing to be less homoplasmic by NextGen sequencing. This case underscores the importance of considering mitochondrial DNA mutations in families with a negative family history, even in offspring of those who have tested negative for a specific mtDNA mutation. © 2013 Wiley Periodicals, Inc.
Human and natural drivers of changing macrophyte community dynamics over 12 years in a Neotropical riverine floodplain system
Authors: Martins Sara Varandas , Milne Judith , Thomaz Sidinei Magela , McWaters Stephanie , Mormul Roger Paulo , Kennedy Michael , Murphy Kevin 
Published: June 2013

ABSTRACTThe Rio Paraná is the world's tenth largest river (discharge in the upper river, studied here, during major flood events exceeds 12 700 m3s‐1). Together with its associated floodplain water bodies, this Neotropical river system supports a freshwater biodiversity of worldwide conservation significance, but one increasingly affected by human pressures, particularly the effects of river impoundment.Multivariate analysis of data from repeated (2000–2002 and 2011) macrophyte–environment surveys of a set of stations within a 230 km stretch of functioning riverine floodplain, downstream of the most recently completed dam on the Upper Paraná, the Porto Primavera Dam, together with published data (from 1999 and 2005–2007), was used to test the hypothesis that human influences might outweigh the importance of natural factors in driving the aquatic vegetation dynamics (macrophyte community composition, alpha‐diversity, and abundance) of this system during the period 1999–2011.The macrophyte communities present showed differences of species composition and abundance that could be strongly related to the scale and duration of the immediately preceding annual flood pulse, as well as local variations in physico‐chemical conditions. For rare Neotropical endemic species, which are a good marker of the conservation status of the system, there was a reasonable degree of stability between the 2000–2002 and 2011 survey periods, with eight of 16 such species being present in both surveys, three present in 2000–2002 only, but an additional five such species found only in 2011.The conclusion is that vegetation changes in the system can be referred both to direct human impacts (river regulation), and to indirect human or natural impacts (floods, alien species invasion byHydrilla verticillata, and local environmental factors). Overall there was evidence that major floods associated with El Niño ‐ Southern Oscillation (ENSO) climatic events had a much greater impact than other drivers, whether natural or anthropogenic.Copyright © 2013 John Wiley & Sons, Ltd.