bluuebunny/crossref_metadata_2025_split huggingface dataset:
No Increased Risk of All-cause Revision up to 10 Years in Patients Who Underwent Bariatric Surgery Before Single-level Lumbar Fusion
Authors: Kuyl Emile-Victor , Gupta Arnav , Parel Philip M. , Quan Theodore , Patel Tushar Ch. , Mesfin Addisu 
Published: August 2024

Study Design:
Retrospective cohort study.

Objective:
This study aimed to assess whether prior bariatric surgery (BS) is associated with higher 10-year surgical complication and revision rates in lumbar spine fusion compared with the general population and morbidly obese patients.

Background:
Obesity accelerates degenerative spine processes, often necessitating lumbar fusion for functional improvement. BS is explored for weight loss in lumbar spine cases, but its impact on fusion outcomes remains unclear. Existing literature on BS before lumbar fusion yields conflicting results, with a limited investigation into long-term spine complications.

Methods:
Utilizing the PearlDiver database, we examined patients undergoing elective primary single-level lumbar fusion, categorizing them by prior BS. Propensity score matching created cohorts from (1) the general population without BS history and (2) morbidly obese patients without BS history. Using Kaplan-Meier and Cox proportional hazard modeling, we compared 10-year cumulative incidence rates and hazard ratios (HRs) for all-cause revision and specific revision indications.

Results:
Patients who underwent BS exhibited a higher cumulative incidence and risk of decompressive laminectomy and irrigation & debridement (I&D) within 10 years postlumbar fusion compared with matched controls from the general population [decompressive laminectomy: HR = 1.32; I&D: HR = 1.35]. Compared with matched controls from a morbidly obese population, patients who underwent BS were associated with lower rates of adjacent segment disease (HR = 0.31) and I&D (HR = 0.64). However, the risk of all-cause revision within 10 years did not increase for patients who underwent BS compared with matched or unmatched controls from the general population or morbidly obese patients (P > 0.05).

Conclusions:
Prior BS did not elevate the 10-year all-cause revision risk in lumbar fusion compared with the general population or morbidly obese patients. However, patients who underwent BS were associated with a lower 10-year risk of I&D when compared with morbidly obese patients without BS. Our study indicates comparable long-term surgical complication rates between patients who underwent BS and these control groups, with an associated reduction in risk of infectious complications when compared with morbidly obese patients. Although BS may address medical comorbidities, its impact on long-term lumbar fusion revision outcomes is limited.
Laser-assisted Abdominoplasty Marking to Achieve a Better Design of Abdominal Scar
Authors: Wongkietkachorn Apinut , Wongkietkachorn Nuttapone , Jomkoh Pojanan , Wongkietkachorn Supawich 
Published: August 2024

Summary:
Ensuring bilateral symmetry when marking for abdominoplasty incision is critical and can be challenging when using traditional landmarks. This study aims to compare the outcomes of laser-assisted abdominoplasty marking to the traditional method. In this prospective study, patients undergoing standard abdominoplasty were included. Abdomens were randomized to determine which half would serve as the dominant side for clinical marking. Marking was first performed using a traditional method and then using a laser level, and any differences were recorded. A total of 50 patients participated in the study. The distance between markings at the most lateral point was as high as 10.0 [7.0–10.0] mm (P < 0.001), as was that at 12 cm (7.0 [5.0–8.0] mm, P = 0.03). However, the difference at 6 cm was 1.0 [0.0–4.0] mm (P < 0.001). Using a laser level during abdominoplasty marking can increase symmetry of the marking.
Arterial blood pressure monitoring in stroke cohorts: the impact of reduced sampling rates to optimise remote patient monitoring
Authors: Ball James D. , Panerai Ronney B. , Henstock Tim , Minhas Jatinder S. 
Published: August 2024

Objective
Remote patient monitoring (RPM) beat-to-beat blood pressure (BP) provides an opportunity to measure poststroke BP variability (BPV), which is associated with clinical stroke outcomes. BP sampling interval (SI) influences ambulatory BPV, but RPM BP SI optimisation research is limited. SI and RPM device capabilities require compromises, meaning SI impact requires investigation. Therefore, this study assessed healthy and stroke subtype BPV via optimised BP sampling, aiding sudden BP change identification and potentially assisting cardiovascular event (recurrent stroke) prediction.

Methods
Leicester Cerebral Haemodynamic Database ischaemic [acute ischaemic stroke (AIS), n = 68] and haemorrhagic stroke (intracerebral haemorrhage, n = 12) patient and healthy control (HC, n = 40) baseline BP data were analysed. Intrasubject and interpatient SD (SDi/SDp) represented individual/population variability with synthetically altered SIs. Matched-filter approaches using cross-correlation function detected sudden BP changes.

Results
At SIs between 1 and 180 s, SBP and DBP SDi staticised while SDp increased at SI < 30 s. Mean BP and HR SDi and SDp increased at SI < 60s. AIS BPV, normalised to SI1s, increased at SI30s (26%–131%) and SI120s (1%–274%). BPV increased concomitantly with SI. Cross-correlation analysis showed HC and AIS BP sudden change detection accuracy reductions with increasing SI. Positive BP deviation detection fell 48.48% (SI10s) to 78.79% (SI75s) in HC and 67.5% (SI10s) to 100% (SI75s) in AIS. Negative BP deviation detection fell 50% (SI10s) to 82.35% (SI75s) in HC and 52.27% (SI10s) to 95.45% (SI75s) in AIS.

Conclusion
Sudden BP change detection and BPV are relatively robust to SI increases within certain limits, but accuracy reductions generate unacceptable estimates, considerable within RPM device design. This research warrants further SI optimisation.
A randomized, double-blind, placebo-controlled study to evaluate the benefits of a standardized Nigella sativa oil containing 5% thymoquinone in reducing the symptoms of seasonal allergy
Authors: Majeed Anju , Majeed Shaheen , Parameswarappa Avinash Kadasiddappa , Murali Avinash , Gudimallam Satish , Siddegowda Chikkalingaiah , Chandrashekar Harshith , Mundkur Lakshmi 
Published: August 2024

Background:
Allergic rhinitis (AR) or seasonal allergy characterized by sneezing, nasal congestion, nasal itching, and nasal discharge, triggered by immune reactions to environmental allergens. Present day customers also monitor the personal improvements in the area of Evidence-Based natural medicines/supplements

Methods:
A randomized, double-blind, placebo-controlled study was conducted on 65 participants aged 18 to 60 years having 2 or more allergic symptoms like sneezing, rhinorrhoea, nasal obstruction, and nasal itching for a cumulative period greater than 1 hour per day. The study participants received a capsule of NSO (250 mg) with 2.5 mg piperine (BioPerine) as a bioavailability enhancer or a placebo, twice a day, after food for 15 days. The primary objectives were evaluated by mean change in Total Nasal Symptom Score and the duration of AR symptoms per day from baseline to Day 15. Secondary endpoints were changes in Total Ocular Symptoms Score, AR symptom frequency and severity, serum Immunoglobulin E levels, and Patient Global Impression of Change scale. Adverse events were monitored throughout the study.

Results:
Sixty-five patients were enrolled and all of them completed the study, N = 33 in NSO and N = 32 in placebo. A significant reduction in Total Nasal Symptom Score and Total Ocular Symptoms Score was observed in the NSO group compared to the placebo, highlighting the potential of NSO in alleviating AR symptoms. The episodes of AR symptoms per day and the frequency of symptoms in 24 hours reduced significantly in 15 days in both groups, but the extent of improvement was significantly higher in NSO compared to placebo. Improvement in Patient Global Impression of Change was also significantly better in NSO compared to the placebo. Serum Immunoglobulin E levels decreased in NSO but were not significantly different from placebo. No clinically significant changes were observed in vital signs, liver and renal function, lipid profile, hematology, fasting blood sugar, or urine analysis at the end of the study.

Conclusion:
The result of the study demonstrates that NSO 250 mg with 2.5 mg piperine is an effective and well-tolerated supplement for the management of AR symptoms.
ChatGPT in medicine: A cross-disciplinary systematic review of ChatGPT’s (artificial intelligence) role in research, clinical practice, education, and patient interaction
Authors: Fatima Afia , Shafique Muhammad Ashir , Alam Khadija , Fadlalla Ahmed Tagwa Kalool , Mustafa Muhammad Saqlain 
Published: August 2024

Background:
ChatGPT, a powerful AI language model, has gained increasing prominence in medicine, offering potential applications in healthcare, clinical decision support, patient communication, and medical research. This systematic review aims to comprehensively assess the applications of ChatGPT in healthcare education, research, writing, patient communication, and practice while also delineating potential limitations and areas for improvement.

Method:
Our comprehensive database search retrieved relevant papers from PubMed, Medline and Scopus. After the screening process, 83 studies met the inclusion criteria. This review includes original studies comprising case reports, analytical studies, and editorials with original findings.

Result:
ChatGPT is useful for scientific research and academic writing, and assists with grammar, clarity, and coherence. This helps non-English speakers and improves accessibility by breaking down linguistic barriers. However, its limitations include probable inaccuracy and ethical issues, such as bias and plagiarism. ChatGPT streamlines workflows and offers diagnostic and educational potential in healthcare but exhibits biases and lacks emotional sensitivity. It is useful in inpatient communication, but requires up-to-date data and faces concerns about the accuracy of information and hallucinatory responses.

Conclusion:
Given the potential for ChatGPT to transform healthcare education, research, and practice, it is essential to approach its adoption in these areas with caution due to its inherent limitations.
The Nurse-Implemented Chronotherapeutic Bundle in Critically Ill Children, RESTORE Resilience (R2): Pilot Testing in a Two-Phase Cohort Study, 2017–2021
Authors: Curley Martha A. Q. , Dawkins-Henry Onella S. , Kalvas Laura Beth , Perry-Eaddy Mallory A. , Georgostathi Georgia , Yuan Ian , Wypij David , Asaro Lisa A. , Zuppa Athena F. , Kudchadkar Sapna R. 
Published: August 2024

OBJECTIVES:
Pilot test the nurse-led chronotherapeutic bundle in critically ill children, RESTORE Resilience (R2).

DESIGN:
A two-phase cohort study was carried out from 2017 to 2021.

SETTING:
Two similarly sized and organized PICUs in the United States.

PATIENTS:
Children 6 months to 17 years old who were mechanically ventilated for acute respiratory failure.

INTERVENTIONS:
R2 seven-item chronotherapeutic bundle, including: 1) replication of child’s pre-hospital daily routine (i.e., sleep/wake, feeding, activity patterns); 2) cycled day-night light/sound modulation; 3) minimal effective sedation; 4) night fasting with bolus enteral daytime feedings; 5) early progressive mobility; 6) nursing care continuity; and 7) parent diaries.

MEASUREMENTS AND MAIN RESULTS:
Children underwent environmental (light, sound) and patient (actigraphy, activity log, salivary melatonin, electroencephalogram) monitoring. Parents completed the Child’s Daily Routine and Sleep Survey (CDRSS) and Family-Centered Care Scale. The primary outcome was post-extubation daytime activity consolidation (Daytime Activity Ratio Estimate [DARE]). Twenty baseline-phase (2017–2019) and 36 intervention-phase (2019–2021) participants were enrolled. During the intervention phase, nurses used the CDRSS to construct children’s PICU schedules. Overall compliance with nurse-implemented R2 elements 1–5 increased from 18% (interquartile range, 13–30%) at baseline to 63% (53–68%) during the intervention phase (p < 0.001). Intervention participants were exposed to their pre-hospitalization daily routine (p = 0.002), cycled day-night light/sound modulation (p < 0.001), and early progressive mobility on more PICU days (p = 0.02). Sedation target identification, enteral feeding schedules, and nursing care continuity did not differ between phases. Parent diaries were seldom used. DARE improved during the intervention phase and was higher pre-extubation (median 62% vs. 53%; p = 0.04) but not post-extubation (62% vs. 57%; p = 0.56).

CONCLUSIONS:
In the PICU, implementation of an individualized nurse-implemented chronotherapeutic bundle is feasible. Children who received the R2 bundle had increased pre-extubation daytime activity consolidation compared to children receiving usual care. Given variation in protocol adherence, further R2 testing should include interprofessional collaboration, pragmatic trial design, and implementation science strategies.
Stressors and Subjective Cognition in Daily Life: Tests of Physical Activity and Age as Moderators
Authors: Stuart Nicole S. , Wen Jin H. , Klaiber Patrick , Puterman Eli , DeLongis Anita , Sin Nancy L. 
Published: August 2024

ABSTRACT

Objective
Growing research indicates that daily stress is associated with poorer same-day cognitive performance, for example, memory and attention. However, it is unclear whether this relationship holds across diverse ages and engagement in physical activity (PA), or whether these factors might buffer the relationship between daily stress and subjective cognitive function.

Methods
Ecological momentary assessment data were collected from adults aged 25 to 88 years across British Columbia, Canada. For 14 days, participants (N = 204) wore a triaxial physical activity monitor, reported stressor occurrence in mobile surveys four times per day, and rated their subjective attention and memory at the end of each day.

Results
Multilevel models evaluated daily stressor occurrence as a predictor of subjective attention and memory, with same-day PA engagement and age as moderators. Subjective attention and memory were lower on days when a stressor had occurred, compared to stressor-free days. Neither PA nor age moderated the within-person associations of daily stressors with subjective cognition.

Conclusion
The lack of stress-buffering effects for same-day PA and age raises questions about the contexts in which PA promotes cognitive functioning and about age-related processes underlying stress and cognition. Future work could examine the mechanisms that might explain the link between daily stress and cognition function, as well as the associations of different intensity and forms of physical activity on stress across age groups.
Applications of Extracellular Matrix Biomaterial in Tongue Reconstruction
Authors: Mosquera Camilo , Kang Sara , Ramirez Carlos A. 
Published: August 2024

Tongue neoplasms are common in the head and neck region and are primarily treated through surgical interventions. Various reconstruction techniques, such as primary closure, skin grafts, skin substitute biomaterials, and free tissue transfer, are used to address the resulting defects. This study provides an overview of our experience utilizing extracellular matrix-based biomaterials (ECM) for the reconstruction of tongue defects and evaluates the mean volumetric size of postsurgical tongue. This retrospective case series evaluated subjects with tongue defects secondary to benign or malignant resections who underwent reconstruction with ECM-based biomaterials at Ascension Hospital from July 2022 to May 2023. Descriptive variables were collected, and descriptive statistical analyses were conducted. The primary outcome was the volume of postsurgical defect reconstructed. Twenty-five subjects were included: 10 had benign pathology and 15 had malignancy. The mean reconstructed defect volume was 12.65 cm3, ranging between 2 and 35 cm3. Postoperative bleeding, mainly linked to anticoagulation medication, occurred in 20% (n=5) of the cases, and the rate of need for additional procedures was 8%. In conclusion, ECM-based biomaterials are suitable for reconstructing varying sizes of postsurgical tongue defects with no donor-site morbidity. Carefully considering patient factors, including anticoagulation medication use and defect volume, is essential in optimizing outcomes.
Water-tank metabarrier for seismic Rayleigh wave attenuation
Authors: Russillo Andrea Francesco , Arena Felice , Failla Giuseppe 
Published: August 2024

An innovative concept of metabarrier is presented for seismic Rayleigh wave attenuation, which consists of a periodic array of cylindrical water tanks acting as resonant units above the soil surface. A pertinent theoretical framework is developed and implemented in COMSOL Multiphysics. The framework treats the dynamics of the water tank by a well-established three-dimensional linear, pressure-based model for fluid-structure interaction under earthquake excitation, accounting for the flexibility of the tank wall; furthermore, the soil is idealized as a homogeneous and isotropic medium. Floquet-Bloch dispersion analysis of the unit cell demonstrates the presence of relevant band gaps in the low-frequency range below 20 Hz and in the higher frequency range as well. The dispersion analysis is validated by comparison with the frequency-domain analysis of a soil domain with a finite array of water tanks. The band gaps are of interest to attenuate seismic Rayleigh waves and, more generally, Rayleigh waves caused by other ground vibration sources such as road or railway traffic. The water-tank resonant units are readily tunable by varying the water level, which allows changing opening frequencies/widths of the wave attenuation zones. This is a remarkable advantage over alternative seismic metamaterials that, in general, are not designed to be tunable.
This article is part of the theme issue ‘Current developments in elastic and acoustic metamaterials science (Part 2)’.
Variable rRNA 2’-O-methylation fine-tunes ribosome function inSaccharomyces cerevisiae
Authors: Gillot Sandra , Marchand Virginie , Motorin Yuri , Baudin-Baillieu Agnès , Namy Olivier 
Published: August 2024

AbstractCellular processes are governed by the regulation of gene expression, often at the level of translation control. The mechanisms of control have been shown to operate at various levels, but there is growing evidence to suggest that rRNA modification patterns play a key role in driving translational modulation of the ribosome. We investigated the intricate relationship between modification status and the decoding activity of the ribosome. We found that the level of 2’-O-methylation at specific nucleotides in the rRNA affects the properties of the ribosome, with consequences for bothSaccharomyces. cerevisiaecell growth and antibiotic sensitivity. More precisely, we demonstrate that methylations within the peptide exit tunnel play an important role in nascent peptide folding. We also demonstrate the modulation of IRES-driven translation by variable methylation at the intersubunit surface of the 60S ribosomal subunit. These findings deepen our understanding of the mechanisms by which 2’-O-methylation confers functional specificity on the ribosome.
TFE3 fusions direct an oncogenic transcriptional program that drives OXPHOS and unveils vulnerabilities in translocation renal cell carcinoma
Authors: Li Jiao , Huang Kaimeng , McBride Fiona , Sadagopan Ananthan , Gallant Daniel S , Thakur Meha , Khanna Prateek , Li Bingchen , Ge Maolin , Weiss Cary N. , Achom Mingkee , Xu Qingru , Huang Kun , Ryback Birgitta A. , Gui Miao , Bar-Peled Liron , Viswanathan Srinivas R. 
Published: August 2024

AbstractTranslocation renal cell carcinoma (tRCC) is an aggressive subtype of kidney cancer driven byTFE3gene fusions, which act via poorly characterized downstream mechanisms. Here we report that TFE3 fusions transcriptionally rewire tRCCs toward oxidative phosphorylation (OXPHOS), contrasting with the highly glycolytic metabolism of most other renal cancers. This TFE3 fusion-driven OXPHOS program, together with heightened glutathione levels found in renal cancers, renders tRCCs sensitive to reductive stress – a metabolic stress state induced by an imbalance of reducing equivalents. Genome-scale CRISPR screening identifies tRCC-selective vulnerabilities linked to this metabolic state, includingEGLN1, which hydroxylates HIF-1α and targets it for proteolysis. Inhibition of EGLN1 compromises tRCC cell growth by stabilizing HIF-1a and promoting metabolic reprogramming away from OXPHOS, thus representing a vulnerability to OXPHOS-dependent tRCC cells. Our study defines a distinctive tRCC-essential metabolic program driven by TFE3 fusions and nominates EGLN1 inhibition as a therapeutic strategy to counteract fusion-induced metabolic rewiring.
Multimodal magnetic resonance imaging characterizes clinical outcome in chronic traumatic brain injury
Authors: Pélégrini-Issac Mélanie , Hezghia Adrienne , Caron Elsa , Delphine Sébastien , Battisti Valentine , Cassereau Didier , Debarle Clara , Lefort Muriel , Lesimple Blandine , Torkomian Grégory , Degos Vincent , Bernard Rémy , Galanaud Damien , Pradat-Diehl Pascale , Perlbarg Vincent , Bayen Eléonore , Puybasset Louis 
Published: August 2024

AbstractModerate to severe traumatic brain injury (TBI) should be considered as a chronic health condition. The corpus callosum is the brain region that suffers most from diffuse axonal injury, leading to long-term functional deficits. Few studies have considered the relationships between inter- and intrahemispheric functional connectivity and structural damages to the corpus callosum in chronic TBI patients. We examined how callosal functional connectivity and white matter alterations relate to clinical outcome using multimodal magnetic resonance imaging (MRI): structural MRI estimates callosal volume, diffusion-weighted MRI enables white matter integrity quantification, resting-state functional MRI assesses neural dysfunction. Seventy-four patients underwent a multimodal MRI session on average 5 years after a moderate-to-severe TBI. Multiple factorial analysis analyzed the relationships between clinical outcome (from severe disability to good recovery, assessed by the Glasgow Outcome Scale extended GOSE), callosal volume, diffusion metrics (fractional anisotropy and mean, axial, and radial diffusivity), and inter- and intrahemispheric functional connectivity. Multiple factorial analysis confirmed that patients with severe disability (GOSE 3-4) had more structural alterations in the corpus callosum than patients with a good recovery (GOSE 7-8). Most importantly, patients able to live independently but unable to work/study in a standard environment (GOSE 5-6) could not be described solely by structural features. They exhibited a lower interhemispheric connectivity between cortical regions mediated by the corpus callosum than patients with a good recovery, and a tendency towards a decrease in intrahemispheric connectivity compared with severely disabled patients. These findings suggest a complex long-term functional impact of moderate-to-severe TBI.