bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disentangling drivers of vertebrate roadkill in a protected area in the Amazon rainforest
Authors: Coeli Gomes de Lucena Costa Andréa , Campos Gomides Samuel 
Published: July 2024

AbstractVertebrates' roadkill impacts many species in natural areas. However, data on this topic in the Amazon domain are still scarce, especially within protected areas. In this study, we analysed data from 2 years of monitoring amphibians, reptiles, mammals and birds' roadkill on five types of terrestrial transport infrastructure in a protected area in the Brazilian Amazon. We tested which vertebrate classes and feeding guilds were most recorded, the influence of seasonality and the spatial pattern of roadkill. In the studied area, 2795 roadkills were recorded, with amphibians suffering the most casualties. Most of the roadkills occurred during the rainy season (57%). Correcting the roadkill data using observer efficiency and carcass persistence time data, we concluded that mortality rates might be underestimated by up to 40 times when compared to raw data. There was no significant difference between feeding guilds concerning the number of fatalities, and rainfall and temperature significantly affected the roadkill pattern of all vertebrate classes. The spatial pattern of roadkill varied between traffic routes and vertebrate class types. The results indicate that amphibians are the most common victims of roadkill, although they are neglected in many roadkill monitoring. Consequently, mitigation strategies should prioritize periods with the highest mortality rates, as rainfall and temperature influence the frequency of these accidents. In addition, different classes of vertebrates have different patterns of impact concentration along traffic routes, which makes mitigation planning more complex. Therefore, planning to reduce vertebrate deaths from roadkill must consider each taxon's particularity and seasonality.
Male contraception: Focus on behavioral and barrier methods
Authors: Kopa Zsolt , Scafa Raffaele , Graziani Andrea , Goulis Dimitrios G. , Ferlin Alberto 
Published: July 2024

AbstractIntroductionMale contraception includes various methods designed to prevent pregnancy by focusing on the male's role in reproduction.ResultsBehavioral methods, such as withdrawal and periodic abstinence, offer non‐invasive alternatives that require self‐control and precise timing to avoid depositing sperm in the female reproductive tract during fertile periods. However, these methods generally have low effectiveness and rely heavily on user adherence and experience. The male condom, a barrier method, provides both contraception and protection against sexually transmitted infections. Its effectiveness relies on correct and consistent use.DiscussionAccess to comprehensive sexual education and medical counseling is essential to dispel the stigma surrounding contraceptive use and correct misconceptions, ensuring proper usage and ultimately contributing to better reproductive health outcomes.
Mitochondria can substitute for parvalbumin to lower cytosolic calcium levels in the murine fast skeletal muscle
Authors: Marcucci Lorenzo , Nogara Leonardo , Canato Marta , Germinario Elena , Raffaello Anna , Carraro Michela , Bernardi Paolo , Pietrangelo Laura , Boncompagni Simona , Protasi Feliciano , Paolocci Nazareno , Reggiani Carlo 
Published: July 2024

AbstractAimParvalbumin (PV) is a primary calcium buffer in mouse fast skeletal muscle fibers. Previous work showed that PV ablation has a limited impact on cytosolic Ca2+ ([Ca2+]cyto) transients and contractile response, while it enhances mitochondrial density and mitochondrial matrix‐free calcium concentration ([Ca2+]mito). Here, we aimed to quantitatively test the hypothesis that mitochondria act to compensate for PV deficiency.MethodsWe determined the free Ca2+ redistribution during a 2 s 60 Hz tetanic stimulation in the sarcoplasmic reticulum, cytosol, and mitochondria. Via a reaction–diffusion Ca2+ model, we quantitatively evaluated mitochondrial uptake and storage capacity requirements to compensate for PV lack and analyzed possible extracellular export.Results[Ca2+]mito during tetanic stimulation is greater in knock‐out (KO) (1362 ± 392 nM) than in wild‐type (WT) (855 ± 392 nM), p < 0.05. Under the assumption of a non‐linear intramitochondrial buffering, the model predicts an accumulation of 725 μmoles/L
fiber (buffering ratio 1:11 000) in KO, much higher than in WT (137 μmoles/L
fiber, ratio 1:4500). The required transport rate via mitochondrial calcium uniporter (MCU) reaches 3 mM/s, compatible with available literature. TEM images of calcium entry units and Mn2+ quenching showed a greater capacity of store‐operated calcium entry in KO compared to WT. However, levels of [Ca2+]cyto during tetanic stimulation were not modulated to variations of extracellular calcium.ConclusionsThe model‐based analysis of experimentally determined calcium distribution during tetanic stimulation showed that mitochondria can act as a buffer to compensate for the lack of PV. This result contributes to a better understanding of mitochondria's role in modulating [Ca2+]cyto in skeletal muscle fibers.
Letter: Role of Helicobacter pylori and metabolic syndrome‐related insulin resistance and lipotoxicity in the pathogenesis of MAFLD and MASH
Authors: Kountouras Jannis , Polyzos Stergios A. , Kazakos Evangelos , Zavos Christos , Grigoriadis Nikolaos , Papanikolaou Ioannis S. , Vardaka Elisabeth , Tzilves Dimitrios , Chatzopoulos Dimitrios , Tzitiridou‐Chatzopoulou Maria , Touloumtzi Maria , Doulberis Michael , Papaefthymiou Apostolis 
Published: July 2024

LINKED CONTENTThis article is linked to Lin et al papers. To view these articles, visit https://doi.org/10.1111/apt.17930 and https://doi.org/10.1111/apt.18182.
Letter: Role of Helicobacter pylori and metabolic syndrome‐related insulin resistance and lipotoxicity in the pathogenesis of MAFLD and MASH—Authors’ reply
Authors: Bansal S. K. , Bansal M. B. 
Published: July 2024

LINKED CONTENTThis article is linked to Bansal et al. papers. To view these articles, visit https://doi.org/10.1111/apt.17930 and https://doi.org/10.1111/apt.18124.
Studying and stimulating a sense of community through co‐productive zine‐making in public libraries
Authors: van Melik Rianne , Kofi Jamea , Landau‐Donnelly Friederike 
Published: July 2024

AbstractThis paper reports on our ongoing experiences of using co‐productive zine‐making as a creative and participatory method in a research project on public libraries as social infrastructures. Engaging different audiences, including library management and staff, patrons and urban government authorities, the project aims to simultaneously study and stimulate a sense of community in public libraries. While many libraries already deploy zine‐making programmes as a low‐cost visitor activity, we use it as both a data collection and community‐building tool. Co‐productive zine‐making offers opportunities for reflection and mutual understanding to foster education, exchange and encounter between different stakeholders. It challenges the traditional power dynamics of knowledge production in academia and beyond. Zine‐making can act as a creative tool that pushes researchers to be more (self‐)reflexive. Yet, despite these benefits, zine‐making does not come without challenges, and therefore requires a specific researchers' skillset. This paper provides insight into both practical and ethical issues we encountered before, during and after the organisation of the first out of five zine‐making workshops in our project, held with community librarians in Rotterdam.
Friend influence and susceptibility to influence on emotions towards math: The role of adolescent temperament
Authors: Kiuru Noona , DeLay Dawn , Tervahartiala Katja , Polet Juho , Hirvonen Riikka 
Published: July 2024

AbstractBackground and AimsPeer relationships during adolescence play an important role in shaping academic outcomes. The present study examined friend influences on emotions towards math, as well as the role of temperament in these influences.SampleThe sample consisted of 350 Finnish students (mean age 13.29 years; 64% girls) who were involved in stable friendship dyads from fall to spring of Grade 7.MethodsIn this two‐wave study, information on adolescents' temperament (i.e., negative emotionality, extraversion, effortful control) and on seven emotions towards math (i.e., enjoyment, hope, pride, anger, anxiety, shame, hopelessness, and boredom) was collected during grade 7. The data were analysed using longitudinal actor‐partner interdependence models.ResultsThe results showed that friends resembled each other in all the investigated math‐related emotions. Furthermore, over and above these initial similarities, friends mutually influenced each other's math‐related enjoyment and anger towards math. Students characterized by higher negative emotionality also influenced their friends with lower levels of negative emotionality towards an increase in math‐related anger and a lack of effortful control made adolescents more susceptible to friend influence over math‐related shame and anxiety.ConclusionOur findings demonstrate that friends influence each other over time in math‐related enjoyment and frustration. Furthermore, high negative emotionality may make adolescents more influential over their friends' math‐related anger and a lack of effortful control may make adolescents more susceptible to friend influence over math‐related shame and anxiety. Thus, the current findings have implications for how peer relations may impact individual outcomes in mathematics, for better or worse.
Seasonal plasticity in sympatric Bicyclus butterflies in a tropical forest where temperature does not predict rainfall
Authors: Mallick Soumen , Granados‐Tello Jorge , van Bergen Erik , Kodandaramaiah Ullasa , Brattström Oskar , Brakefield Paul M. , Molleman Freerk 
Published: July 2024

AbstractWhile variation in temperature appears to be the main environmental cue for plasticity in adult traits in many species of Mycalesina, relying on temperature would result in a mismatch between adult phenotype and environment in some regions. We measured phenotypes of six species of Bicyclus butterflies (Nymphalidae: Satyrinae: Mycalesina) in a humid tropical forest with two rainy seasons per year and modest unimodal seasonal temperature variation, such that temperature does not predict rainfall and butterflies can reproduce year‐round. The butterflies showed subtle temporal variation in body size and relative eyespot size, while relative androconia length was robust to temporal environmental variation. After higher temperatures, body size tended be smaller, and relative eyespot size was larger for some species‐eyespot combinations. This indicates that these butterflies follow the “hotter is smaller” rule, and show developmental plasticity in eyespot size that is typical in this clade. Eyespot sizes tended to be correlated with each other, except Cu1 in B. auricruda and some eyespots that always remained very small. Androconia length was not related to eyespot size. This pattern of correlations suggests conserved cue‐use and shared mechanisms for eyespot size using both temperature and rainfall‐related cues, with some exceptions.
Diversity and dominance in bird assemblages across habitats in the Ñeembucú wetlands complex
Authors: Ortiz Fátima , Salinas Patricia , Mendoza Medes , Zárate Griselda , da Motta Fátima Piris , Esquivel Alberto , Núñez Karina , Silla Fernando 
Published: July 2024

AbstractUnderstanding how diversity responds to habitat heterogeneity in a landscape is a central issue for implementing effective conservation plans. In this study, we analyzed how the composition and abundance of neotropical bird assemblages vary among habitats in the Ñeembucú Wetlands Complex, the largest wetland system in Paraguay. Bird surveys were conducted during 1 year within dominant habitats in the landscape: riparian forests, natural grasslands, savannas, and anthropized sites. The Ñeembucú Wetlands Complex showed a high bird richness (209 species) that contrasted with a pattern of dominance by a small set of 16 species that comprised half of the abundance. This set of oligarchic species consists of generalist species that exploited a wide variety of habitats and were well adapted to human disturbance, contributing to an important overlap in the composition of assemblages. However, despite this overall similarity, there is still significant differentiation in bird assemblages, especially between habitats with the most contrasting vegetation physiognomy. Riparian forests and savannas showed higher diversity values than the more structurally homogeneous grasslands. Also, all natural habitats showed, in general, higher diversity values than anthropized sites. Oligarchic species had higher importance in anthropized environments, which also had the most uneven distribution of abundance between species, indicating the dominance by a smaller number of species and the loss of ecological diversity as farmland and urban development increase.Abstract in Spanish is available with online material.
Advancements in dental implantology: The alveolar ridge split technique for enhanced osseointegration
Authors: Luo Feng , Mo Yafei , Jiang Jiapei , Wen Jing , Ji Yixuan , Li Lei , Wan Qianbing 
Published: July 2024

AbstractThe alveolar ridge split (ARS) technique is a pivotal advancement in dental implantology, addressing the limitation of insufficient bone width for implant placement. This review traces the historical development of ARS from its initial conceptualization to current practices and future directions. Emphasizing the technique's development, indications, procedural overview, and osteotomy variations, we highlight its minimally invasive nature, which reduces patient morbidity and treatment time. This article reviews various osteotomy methods within ARS, examining their applications, benefits, and limitations. Furthermore, it discusses the technique's role in expanding treatment options for patients with compromised alveolar structures, underpinned by a high implant survival rate and the potential for immediate implant placement. We also cover the necessity of meticulous surgical technique, the importance of patient‐specific factors, and the promising future of ARS facilitated by advancements in biomaterials and regenerative medicine. In summary, this review provides a comprehensive overview of ARS, offering valuable insights for dental professionals and informing future clinical practices and research in implantology.
Patch tests in non‐immediate cutaneous adverse drug reactions: Late readings on Day 4 is more sensitive than on Day 3
Authors: Matei Ilaria , Bettuzzi Thomas , Weill Amandine , Gener Gwendeline , Hareth Kamar Bel , Margaux Fleck , Verlinde‐Carvalho Muriel , Paul Muriel , Ingen‐Housz‐Oro Saskia , Assier Haudrey 
Published: July 2024

AbstractBackgroundPatch tests (PTs) are recommended to identify the culprit drug in non‐immediate cutaneous adverse drug reactions (NICADRs). We recently reported that, in patients with NICADRs, a unique reading of PTs at day (D)2 compared with an additional second late reading at D4 missed almost half (45.3%) of the positive PTs.ObjectivesTo assess the change in sensitivity of the PT reading on D4 compared with the reading on D3.MethodsWe performed a retrospective (July 2020–June 2023) monocentric study of patients who had PTs with two readings for a NICADR. We compared reading on D3 and the second reading on D4 for the suspected drug (primary outcome) and for the related drugs tested simultaneously (secondary outcome).ResultsDuring the study period, 249 patients underwent patch testing with D3 and D4 readings. Regarding the primary outcome, the first reading at D3 was positive for 13.7% of patients, and the reading at D4 for 24.9% of patients (p < 0.0001). Regarding the secondary outcome, only 9.6% of patients had all their positive PT at D3 compared with 24.9% of patients at D4 (p < 0.0001). Considering the evaluated drug classes, no statistical difference was observed. However, we highlight that D3 reading detected all positive carbamazepine PTs (n = 3) while positive clindamycin PTs (n = 4) were identified only with the help of the second reading on D4.ConclusionThis study showed that, an additional D4 reading compared with a single D3 reading enhanced the sensitivity of PTs to identify culprit drugs and related. Further studies should replicate these findings and evaluate the medico‐economic balance and safety of a single reading of PTs on D4.
Drug–drug interactions between pemafibrate and statins on pharmacokinetics in healthy male volunteers: Open‐label, randomized, 6‐sequence, 3‐period crossover studies
Authors: Kamimura Tomohiro , Hounslow Neil , Suganami Hideki , Tanigawa Ryohei 
Published: July 2024

AbstractElevated triglyceride levels are associated with an increased risk of cardiovascular events despite guideline‐based statin treatment of low‐density lipoprotein cholesterol. Peroxisome proliferator‐activated receptor α (PPARα) agonists exert a significant triglyceride‐lowering effect. However, combination therapy of PPARα agonists with statins poses an increased risk of rhabdomyolysis, which is rare but a major concern of the combination therapy. Pharmacokinetic interaction is suspected to be a contributing factor to the risk. To examine the potential for combination therapy with the selective PPARα modulator (SPPARMα) pemafibrate and statins, drug–drug interaction studies were conducted with open‐label, randomized, 6‐sequence, 3‐period crossover designs for the combination of pemafibrate 0.2 mg twice daily and each of 6 statins once daily: pitavastatin 4 mg/day (n = 18), atorvastatin 20 mg/day (n = 18), rosuvastatin 20 mg/day (n = 29), pravastatin 20 mg/day (n = 18), simvastatin 20 mg/day (n = 20), and fluvastatin 60 mg/day (n = 19), involving healthy male volunteers. The pharmacokinetic parameters of pemafibrate and each of the statins were similar regardless of coadministration. There was neither an effect on the systemic exposure of pemafibrate nor a clinically important increase in the systemic exposure of any of the statins on the coadministration although the systemic exposure of simvastatin was reduced by about 15% and its open acid form by about 60%. The HMG‐CoA reductase inhibitory activity in plasma samples from the simvastatin and pemafibrate combination group was about 70% of that in the simvastatin alone group. In conclusion, pemafibrate did not increase the systemic exposure of statins, and vice versa, in healthy male volunteers.
Bariatric arterial embolization slows gastric emptying and improves postprandial glycaemia in obese dogs with impaired glucose tolerance
Authors: Wang Zhi , Cao Qing‐Yue , Xiang Chunjie , Yu Chao , Xie Cong , Luo Biao , Zhu Dan‐Qi , Xu Yi , Chen Ya‐Jing , Wu Tongzhi , Teng Gao‐Jun 
Published: July 2024

AbstractAimTo evaluate the effects of bariatric arterial embolization (BAE) on gastric emptying of, and the glycaemic response to, an oral glucose load in an obese canine model with impaired glucose tolerance.MethodsEleven male dogs were fed a high‐fat, high‐fructose diet for 7 weeks before receiving BAE, which involved selective embolization of the left gastric artery (n = 5; 14.9 ± 0.8 kg), or the sham (n = 6; 12.6 ± 0.8 kg) procedure. Postprocedural body weight was measured weekly for 4 weeks. Prior to and at 4 weeks postprocedure, a glucose solution containing 13C‐acetate was administered orally for evaluation of the gastric half‐emptying time (T50) and the glycaemic response. The relationship between the changes in the blood glucose area under the curve over the first 60 minutes (AUC0‐60min) and the T50 was also assessed.ResultsAt 4 weeks postprocedure, BAE reduced body weight (BAE vs. the sham procedure: −5.7% ± 0.9% vs. 3.5% ± 0.9%, P < .001), slowed gastric emptying (T50 at baseline vs. postprocedure: 75.5 ± 2.0 vs. 82.5 ± 1.8 minutes, P = .021 in the BAE group; 73.8 ± 1.8 vs. 74.3 ± 1.9 minutes in the sham group) and lowered the glycaemic response to oral glucose (AUC0‐60min at baseline vs. postprocedure: 99.2 ± 13.7 vs. 67.6 ± 9.8 mmol·min/L, P = .043 in the BAE group; 100.2 ± 13.4 vs. 103.9 ± 14.6 mmol·min/L in the sham group). The change in the glucose AUC0‐60min correlated inversely with that of the T50 (r = −0.711; P = .014).ConclusionsIn a canine model with impaired glucose tolerance, BAE, while reducing body weight, slowed gastric emptying and attenuated the glycaemic response to an oral glucose load.
Efficacy and safety of insulin glargine 300 U/mL in people with type 2 diabetes in China: The INITIATION study
Authors: Chen Liming , Wen Binhong , Liu Haixia , Wu Hongmei , Duan Binhong , Shu Hongyan , Zhang Qiu , Wu Xiaohong , Li Min , Han Yanfang , Kang Lei , Zhang Minlu 
Published: July 2024

AbstractAimTo evaluate the efficacy and safety of insulin glargine 300 U/mL (Gla‐300) in people with suboptimally controlled type 2 diabetes (T2D) in China.MethodsINITIATION (NCT05002933) was a prospective, interventional, multicentre, single‐arm, phase IV study conducted in China. Individuals with suboptimally controlled T2D who were insulin naïve or switching from another basal insulin (insulin experienced) were included. The primary endpoint was the change in HbA1c from baseline to week 24. Safety assessments included hypoglycaemia and adverse events (AEs).ResultsIn total, 568 participants were enrolled and 562 initiated Gla‐300 treatment (189 in the insulin‐naïve subgroup; 373 in the insulin‐experienced subgroup). At week 24, the mean ± standard error (SE) change in HbA1c from baseline was −0.91% ± 0.05% (−9.9 ± 0.5 mmol/mol; P < .0001). Significant HbA1c reductions were also observed in the insulin‐naïve (mean ± SE change: −1.38% ± 0.09% [−15.1 ± 1.0 mmol/mol]) and insulin‐experienced (−0.68% ± 0.05% [−7.4 ± 0.5 mmol/mol]) subgroups (both P < .0001). During the 24‐week treatment period, the incidence of confirmed hypoglycaemia (plasma glucose ≤ 3.9 mmol/L) was 39.7% for all hypoglycaemia and 13.3% for nocturnal hypoglycaemia; the incidence of severe hypoglycaemia was low (0.5%). Overall, treatment‐emergent AEs (TEAEs) were reported in 126 participants (22.4%), with no serious treatment‐related TEAEs.ConclusionsGla‐300 was effective in improving glycaemic control and had a relatively low risk of hypoglycaemia in people with suboptimally controlled T2D who were insulin naïve or switching from another basal insulin in China.