bluuebunny/crossref_metadata_2025_split huggingface dataset:
Locus coeruleus contrast and diffusivity metrics differentially relate to age and memory performance
Authors: Bennett Ilana J. , Langley Jason , Sun Andrew , Solis Kitzia , Seitz Aaron R. , Hu Xiaoping P. 
Published: July 2024

AbstractNeurocognitive aging researchers are increasingly focused on the locus coeruleus, a neuromodulatory brainstem structure that degrades with age. With this rapid growth, the field will benefit from consensus regarding which magnetic resonance imaging (MRI) metrics of locus coeruleus structure are most sensitive to age and cognition. To address this need, the current study acquired magnetization transfer- and diffusion-weighted MRI images in younger and older adults who also completed a free recall memory task. Results revealed significantly larger differences between younger and older adults for maximum than average magnetization transfer-weighted contrast (MTC), axial than mean or radial single-tensor diffusivity (DTI), and free than restricted multi-compartment diffusion (NODDI) metrics in the locus coeruleus; with maximum MTC being the best predictor of age group. Age effects for all imaging modalities interacted with sex, with larger age group differences in males than females for MTC and NODDI metrics. Age group differences also varied across locus coeruleus subdivision for DTI and NODDI metrics, and across locus coeruleus hemispheres for MTC. Within older adults, however, there were no significant effects of age on MTC or DTI metrics, only an interaction between age and sex for free diffusion. Finally, independent of age and sex, higher restricted diffusion in the locus coeruleus was significantly related to better (lower) recall variability, but not mean recall. Whereas MTC has been widely used in the literature, our comparison between the average and maximum MTC metrics, inclusion of DTI and NODDI metrics, and breakdowns by locus coeruleus subdivision and hemisphere make important and novel contributions to our understanding of the aging of locus coeruleus structure.
The influence of HKUST-1 and MOF-76 hand grinding/mechanical activation on stability, particle size, textural properties and carbon dioxide sorption
Authors: Zelenka Tomáš , Baláž Matej , Férová Marta , Diko Pavel , Bednarčík Jozef , Királyová Alexandra , Zauška Ľuboš , Bureš Radovan , Sharda Pooja , Király Nikolas , Badač Aleš , Vyhlídalová Jana , Želinská Milica , Almáši Miroslav 
Published: July 2024

AbstractIn this study, we explore the mechanical treatment of two metal–organic frameworks (MOFs), HKUST-1 and MOF-76, applying various milling methods to assess their impact on stability, porosity, and CO2 adsorption capacity. The effects of different mechanical grinding techniques, such as high-energy ball milling and hand grinding, on these MOFs were compared. The impact of milling time, milling speed and ball size during high-energy ball milling was assessed via the Design of Experiments methodology, namely using a 33 Taguchi orthogonal array. The results highlight a marked improvement in CO2 adsorption capacity for HKUST-1 through hand milling, increasing from an initial 25.70 wt.% (5.84 mmol g-1) to 41.37 wt.% (9.40 mmol g-1), marking a significant 38% increase. In contrast, high-energy ball milling seems to worsen this property, diminishing the CO2 adsorption abilities of the materials. Notably, MOF-76 shows resistance to hand grinding, closely resembling the original sample’s performance. Hand grinding also proved to be well reproducible. These findings clarify the complex effects of mechanical milling on MOF materials, emphasising the necessity of choosing the proper processing techniques to enhance their stability, texture, and performance in CO2 capture and storage applications.
High levels of high-density lipoprotein cholesterol may increase the risk of diabetic kidney disease in patients with type 2 diabetes
Authors: Wang Huabin , Wu Junqi , Lin Meili , Hu Yifei , Ma Yongjun 
Published: July 2024

AbstractStudies have indicated that low high-density lipoprotein cholesterol (HDL-C) level is an important risk factor for diabetic kidney disease (DKD) in patients with type 2 diabetes (T2D). However, whether higher HDL-C levels decrease the risk of developing DKD remains unclear. This study aimed to clarify the relationship between HDL-C levels and DKD risk in individuals with T2D in China. In total, 936 patients with T2D were divided into DKD and non-DKD groups. The association between HDL-C levels and DKD risk was evaluated using logistic regression analysis and restricted cubic spline curves adjusted for potential confounders. Threshold effect analysis of HDL-C for DKD risk was also performed. Higher HDL-C levels did not consistently decrease the DKD risk. Furthermore, a nonlinear association with threshold interval effects between HDL-C levels and the incidence of DKD was observed. Patients with HDL-C ≤ 0.94 mmol/L or HDL-C > 1.54 mmol/L had significantly higher DKD risk after adjusting for confounding factors. Interestingly, the association between high HDL-C levels and increased DKD risk was more significant in women. A U-shaped association between HDL-C levels and DKD risk was observed; therefore, low and high HDL-C levels may increase the DKD risk in patients with T2D.
Lattice excitations in NdFeO3 through polarized optical spectroscopies
Authors: Gomes M. M. , Vilarinho R. , Zhao H. , Íñiguez-González J. , Mihalik M. , Mihalik M. , Maia A. , Goian V. , Nuzhnyy D. , Kamba S. , Moreira J. Agostinho 
Published: July 2024

AbstractThe possibility of inducing new polar and/or magnetic transient states through the pumping of optical phonons towards the non-linear regime has renewed the scientific interest in orthoferrites. Nonetheless, to perform these studies it is fundamental to have a deep knowledge of the lattice excitations at equilibrium conditions. In this work, we present a complete characterization of the optically-active zone-center phonons in NdFeO3 single crystals at room temperature by means of polarized Raman and infrared spectroscopies. The study is complemented with polarized infrared spectroscopy at 4 K and unpolarized Raman scattering at 10 K. The predicted polar phonons were successfully observed together with some of the crystal-field excitations. First-principles simulations further allow the eigenmode and symmetry assignments of the optical phonons. The calculated atomic motions of each mode are of significant interest, as they are common for all orthoferrites and to most of the large family of orthorhombic Pbnm perovskites.
Asymptomatic herpes simplex virus brain infection elicits cellular senescence phenotypes in the central nervous system of mice suffering multiple sclerosis-like disease
Authors: Duarte Luisa F. , Villalobos Verónica , Farías Mónica A. , Rangel-Ramírez Ma. Andreina , González-Madrid Enrique , Navarro Areli J. , Carbone-Schellman Javier , Domínguez Angélica , Alvarez Alejandra , Riedel Claudia A. , Bueno Susan M. , Kalergis Alexis M. , Cáceres Mónica , González Pablo A. 
Published: July 2024

AbstractExperimental autoimmune encephalomyelitis (EAE) is a demyelinating disease affecting the central nervous system (CNS) in animals that parallels several clinical and molecular traits of multiple sclerosis in humans. Herpes simplex virus type 1 (HSV-1) infection mainly causes cold sores and eye diseases, yet eventually, it can also reach the CNS, leading to acute encephalitis. Notably, a significant proportion of healthy individuals are likely to have asymptomatic HSV-1 brain infection with chronic brain inflammation due to persistent latent infection in neurons. Because cellular senescence is suggested as a potential factor contributing to the development of various neurodegenerative disorders, including multiple sclerosis, and viral infections may induce a premature senescence state in the CNS, potentially increasing susceptibility to such disorders, here we examine the presence of senescence-related markers in the brains and spinal cords of mice with asymptomatic HSV-1 brain infection, EAE, and both conditions. Across all scenarios, we find a significant increases of senescence biomarkers in the CNS with some differences depending on the analyzed group. Notably, some senescence biomarkers are exclusively observed in mice with the combined conditions. These results indicate that asymptomatic HSV-1 brain infection and EAE associate with a significant expression of senescence biomarkers in the CNS.
Magnetically controlled bacterial turbulence
Authors: Beppu K. , Timonen J. V. I. 
Published: July 2024

AbstractConcentrated active agents can exhibit turbulent-like flows reminiscent of hydrodynamic turbulence. Despite its importance, the influence of external fields on active turbulence remains largely unexplored. Here we demonstrate the ability to control the swimming direction and active turbulence of Bacillus subtilis bacteria using external magnetic fields. The control mechanism leverages the magnetic torque experienced by the non-magnetic, rod-shaped bacteria in a magnetizable medium containing superparamagnetic nanoparticles. This allows aligning individual bacteria with the magnetic field, leading to a nematically aligned state over millimetric scales with minute transverse undulations and flows. Turning off the field releases the alignment constraint, leading to directly observable hydrodynamic instability of the dipole pushers. Our theoretical model predicts the intrinsic length scale of this instability, independent of the magnetic field, and provides a quantitative control strategy. Our findings suggest that magnetic fields and torques can be excellent tools for controlling non-equilibrium phase transitions in active systems.
Towards machine learning-based quantitative hyperspectral image guidance for brain tumor resection
Authors: Black David , Byrne Declan , Walke Anna , Liu Sidong , Di Ieva Antonio , Kaneko Sadahiro , Stummer Walter , Salcudean Tim , Suero Molina Eric 
Published: July 2024

Abstract
Background
Complete resection of malignant gliomas is hampered by the difficulty in distinguishing tumor cells at the infiltration zone. Fluorescence guidance with 5-ALA assists in reaching this goal. Using hyperspectral imaging, previous work characterized five fluorophores’ emission spectra in most human brain tumors.

Methods
In this paper, the effectiveness of these five spectra was explored for different tumor and tissue classification tasks in 184 patients (891 hyperspectral measurements) harboring low- (n = 30) and high-grade gliomas (n = 115), non-glial primary brain tumors (n = 19), radiation necrosis (n = 2), miscellaneous (n = 10) and metastases (n = 8). Four machine-learning models were trained to classify tumor type, grade, glioma margins, and IDH mutation.

Results
Using random forests and multilayer perceptrons, the classifiers achieve average test accuracies of 84–87%, 96.1%, 86%, and 91% respectively. All five fluorophore abundances vary between tumor margin types and tumor grades (p < 0.01). For tissue type, at least four of the five fluorophore abundances are significantly different (p < 0.01) between all classes.

Conclusions
These results demonstrate the fluorophores’ differing abundances in different tissue classes and the value of the five fluorophores as potential optical biomarkers, opening new opportunities for intraoperative classification systems in fluorescence-guided neurosurgery.
Physiology of malate dehydrogenase and how dysregulation leads to disease
Authors: Parente Amy D. , Bolland Danielle E. , Huisinga Kathryn L. , Provost Joseph J. 
Published: July 2024

Abstract
Malate dehydrogenase (MDH) is pivotal in mammalian tissue metabolism, participating in various pathways beyond its classical roles and highlighting its adaptability to cellular demands. This enzyme is involved in maintaining redox balance, lipid synthesis, and glutamine metabolism and supports rapidly proliferating cells’ energetic and biosynthetic needs. The involvement of MDH in glutamine metabolism underlines its significance in cell physiology. In contrast, its contribution to lipid metabolism highlights its role in essential biosynthetic processes necessary for cell maintenance and proliferation. The enzyme’s regulatory mechanisms, such as post-translational modifications, underscore its complexity and importance in metabolic regulation, positioning MDH as a potential target in metabolic dysregulation. Furthermore, the association of MDH with various pathologies, including cancer and neurological disorders, suggests its involvement in disease progression. The overexpression of MDH isoforms MDH1 and MDH2 in cancers like breast, prostate, and pancreatic ductal adenocarcinoma, alongside structural modifications, implies their critical role in the metabolic adaptation of tumor cells. Additionally, mutations in MDH2 linked to pheochromocytomas, paragangliomas, and other metabolic diseases emphasize MDH’s role in metabolic homeostasis. This review spotlights MDH’s potential as a biomarker and therapeutic target, advocating for further research into its multifunctional roles and regulatory mechanisms in health and disease.
Scholarship of Teaching and Learning Research in Communication Sciences and Disorders Journals: An Exploratory Survey of the Recent Literature
Authors: Boult Johanna , Duggar David , Currie Stephanie , Evers Hanna , McLaughlin Blair , Jilla Anna M. 
Published: July 2024

Purpose:
Inspired by a preliminary survey of the Scholarship of Teaching and Learning (SoTL) literature conducted by Friberg et al. (2014), the current study aimed to expand the original study's findings—that SoTL was rarely published in the communication sciences and disorders (CSD) literature from 2009 to 2013—to the subsequent 8-year period (2014–2021). The latter period was of particular relevance considering the dissolution of one American Speech-Language-Hearing Association (ASHA)–affiliated publication and the addition of another non–ASHA-affiliated publication during that time.

Method:

Ten peer-reviewed CSD journals and the articles published in them were identified via a survey of the literature that used narrowly defined criteria developed in collaboration with a librarian. Five trained CSD graduate student raters compared a definition of SoTL to article abstracts to determine whether each should have been categorized as SoTL. Part 1 of the study investigated an 8-year time span, Part 2 investigated the remaining nine journals in the subsequent 5 years, and Part 3 investigated publication rates of SoTL in
Teaching and Learning in Communication Sciences & Disorders
(
TLCSD
) alone.

Results:

Part 1 of the study revealed that publication rates of SoTL were extremely low in the 10 surveyed CSD journals in the 8-year time span investigated. A similar and diminishing trend was found in Part 2. Even smaller percentages of journals were dedicated to SoTL. Part 3 confirmed that relatively large amounts of CSD-specific SoTL have been published in
TLCSD
since its inception in 2017.

Conclusions:

As of 2021, SoTL articles continued to be uncommonly published in CSD journals. Until recently, scholarly teachers attempting to apply SoTL in the classroom had limited resources. Beginning in 2017,
TLCSD
has provided an outlet for SoTL, whereas other CSD journals seem to have published less of it. Reform of publication, peer review, tenure, and promotion policies and procedures is called for so that SoTL might be included as a valid scientific endeavor.
Parent-Mediated Intervention for Autistic Children Offered Through In-Person and Telepractice Modalities
Authors: Sundarrajan Madhu , Franco Jessica 
Published: July 2024

Purpose:
The COVID-19 pandemic thrust telepractice into the mainstream as a primary service delivery model. While some populations and providers were adversely impacted by this shift, there were some intervention approaches that became even more popular. Parent-mediated intervention (PMI) has been shown to be effective through both in-person and telepractice service delivery models. With PMI, caregivers learn language facilitation strategies and implement them with their child. Project SKILLS (Skills and Knowledge for Language Learning Success) is a PMI program for autistic children funded by a state-level autism grant program. The primary goal of SKILLS is training caregivers in language facilitation techniques to promote communication and language skills. It uses the Project ImPACT (Improving Parents as Communication Teachers) curriculum that is commercially available and supported by previous research. SKILLS also includes variations for neurodiversity-affirming practice and culturally and linguistically diverse families. Project SKILLS has offered both in-person and telepractice delivery since its inception in 2016, making it possible to compare results across the two modalities.

Conclusions:
Project SKILLS has successfully implemented PMI for autistic children through both in-person and telepractice sessions. Clinically, children have made similar gains in social communication and language regardless of the modality. Caregivers also demonstrated similar progress with intervention fidelity, with some added advantages for families participating via telepractice. Telepractice may become a preferred service delivery model of PMI, especially for families living in geographically inaccessible locations with limited access to qualified providers.
Segmenttherapie: Dermatom als Schlüssel
Authors: Rathay Uwe 
Published: July 2024

SummaryDie Segmenttherapie nutzt als Methode der Neuraltherapie die (insbesondere über Spinalnerven und Sympathikus) segmentale Verschaltung von Haut, Muskel, Knochen und Organ, um über Dermatome auf reflektorisch mit diesen verbundene Organe Einfluss zu nehmen. Die Behandlung nutzt 4 Grundprinzipien: segmentale Innervation, Palpation und Diagnose, Behandlung von Segmentdysfunktionen sowie die Injektion von Lokalanästhetika, zum Beispiel in Form einer Quaddelung im Dermatom. Zu den wichtigsten Indikationen zählen Rücken-, Kopf-, Muskel-, Narben- und Gelenkschmerzen, aber auch Verdauungsstörungen oder wie im vorgestellten Fall Folgen einer Cholezystektomie.
Form trifft Funktion
Authors: Corts Magga 
Published: July 2024

SummaryFür die Funktion der Wirbelsäule spielen die knöcherne Ausgestaltung, die evolutionär bedingte Aufrichtung, aber vor allem auch die komplexe Funktionalität, Sinneswahrnehmung und die damit korrespondierenden Strukturen eine entscheidende Rolle. Multifunktionale Knotenpunkte, nervale Strukturen und Weichteile, die untrennbar mit der Wirbelsäule in Verbindung stehen, wirken als komplexes funktionales System zusammen. Aufgrund vielfältiger Wechselwirkungen können Wirbelsäulendysfunktionen zu – zunächst unerwarteten – Beschwerdebildern führen, jeweils mit einer Vielzahl an Behandlungsperspektiven, zum Beispiel bei Störungen der visuellen Fokussierung, Tinnitus, Schwindel, Gleichgewichtsstörungen, Übelkeit, vegetativer Dystonie, Muskelhartspann, Herzrhythmusstörungen oder Menstruationsbeschwerden
A Rare Case of Unruptured Small Aneurysm Arising from the Posterior Surface of Proximal A1 Segment, Projecting Posterior-Inferiorly and Entangled with Multiple Perforators from the A1 Segment
Authors: Kale Samir Jagannath , Tanaka Riki , Okubo Mai , Sasaki Kento , Miyatani Kyosuke , Yamada Yasuhiro , Komatsu Fuminari , Kato Yoko 
Published: July 2024

AbstractAneurysm arising from the A1 segment of the anterior cerebral artery is rare. Aneurysm of the A1 segment even being small tend to rupture early. They tend to develop along the with various vascular anomalies of the vessels arising from the A1 segment. Use of computational fluid dynamics and hemodynamic consideration is of importance in this aneurysm. In this report we describe a 57-year-old woman with a small, unruptured A1 segment aneurysm arising from the proximal segment of the posterior surface of A1, and pointing posterior-inferiorly with multiple perforators entangling around for which microsurgical clipping was done. Intraoperative clipping of the aneurysm and salvaging the multiple perforators were challenging. We report a rare case of an A1 segment aneurysm arising from the posterior surface facing with multiple perforators. It is of significance to understand that a small, unruptured A1 aneurysm can arise from the posterior surface of the A1 segment with projection posterior-inferiorly making it deeper in location with multiple perforators entangling it; hence, it is challenging to treat without causing neurological deficits.
Incidental Visualization of Gallbladder on Post-therapy [177Lu]Lu-DOTATATE Scintigraphy Mimicking a Liver Metastasis in a Duodenal Neuroendocrine Tumor
Authors: Baberwal Parth , Parghane Rahul , Basu Sandip 
Published: July 2024

AbstractWe present a rare case of physiological uptake of [177Lu]Lu-DOTATATE in the gallbladder, observed post-therapy, in a 47-year-old man with grade I duodenal neuroendocrine tumor (NET), despite no uptake being observed pre-therapy in the somatostatin receptor-positron emission tomography. On planar scintigraphy, the gallbladder uptake could have been misidentified as liver metastasis. By utilizing single photon emission computed tomography/computed tomography imaging, we were able to precisely localize the tracer and obtain anatomical morphological characteristics, thereby averting the potential for misinterpretation of liver metastasis resulting from the gallbladder's physiological uptake of [177Lu]Lu-DOTATATE in NET patients.
Leaving messages as coproduction: impact of government COVID-19 non-pharmaceutical interventions on citizens’ online participation in China
Authors: Zhang Pan , Bai Zhouling 
Published: July 2024

AbstractBecause non-pharmaceutical interventions are an essential part of pandemic influenza control planning, the complex impacts of such measures must be clearly and comprehensively understood. Research has examined the health and environmental effects of non-pharmaceutical interventions, but has not yet examined their socio-political effects. Using data from the COVID-19 pandemic period, this article examined the impact of non-pharmaceutical interventions on people’s online participation in China in 2020. Using the difference-in-differences method, it showed that counter-COVID-19 non-pharmaceutical interventions in Chinese cities led to a 0.217 increase in daily messages to City Party Secretaries, which were consistent with findings of an alternative counterfactual estimator and other additional robustness tests. The effects of non-pharmaceutical interventions were larger in cities with better economic conditions, better telecommunication foundations, and better-educated residents. Mechanism analyses implied that the increase in online participation resulted from not only citizens’ increased actual demand for seeking help and expressing thanks but also their active coproduction activities to address the crisis. Overall, this study identified the socio-political effects of counter-pandemic non-pharmaceutical interventions and discussed how these interventions could be optimized.