bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epigenetic Downregulation of SFRP4 Contributes to Epidermal Hyperplasia in Psoriasis
Authors: Bai Jing , Liu Zhaoyuan , Xu Zhenyao , Ke Fang , Zhang Lingyun , Zhu Huiyuan , Lou Fangzhou , Wang Hong , Fei Ye , Shi Yu-Ling , Wang Honglin 
Published: April 2015

Abstract
Psoriasis is a chronic recurrent inflammatory skin disorder characterized by the dysregulated cross-talk between epidermal keratinocytes and immune cells, leading to keratinocyte hyperproliferation. Several studies demonstrated that Wnt pathway genes were differentially expressed in psoriatic plaques and likely were involved in the pathophysiology of disease. However, the molecular mechanisms underlying Wnt signaling regulation in epidermal hyperplasia in psoriasis remain largely unknown. We report that the expression of secreted frizzled-related protein (SFRP) 4, a negative regulator of the Wnt signaling pathway, was diminished in lesional skin of mouse models and patients with psoriasis. SFRP4 directly inhibited excessive keratinocyte proliferation evoked by proinflammatory cytokines in vitro. Pharmacological inhibition of Wnt signaling or intradermal injection of SFRP4 decreased the severity of the psoriasiform skin phenotype in vivo, including decreased acanthosis and reduced leukocyte infiltration. Mechanistically, we identified that aberrant promoter methylation resulted in epigenetic downregulation of SFRP4 in inflamed skin of patients with psoriasis and in the IL-23–induced mouse model. Our findings suggest that this epigenetic event is critically involved in the pathogenesis of psoriasis, and the downregulation of SFRP4 by CpG island methylation is one possible mechanism contributing to the hyperplasia of epidermis in the disease.
A Unique Mouse Strain That Develops Spontaneous, Iodine-Accelerated, Pathogenic Antibodies to the Human Thyrotrophin Receptor
Authors: Rapoport Basil , Aliesky Holly A. , Banuelos Bianca , Chen Chun-Rong , McLachlan Sandra M. 
Published: April 2015

Abstract
Abs that stimulate the thyrotropin receptor (TSHR), the cause of Graves’ hyperthyroidism, only develop in humans. TSHR Abs can be induced in mice by immunization, but studying pathogenesis and therapeutic intervention requires a model without immunization. Spontaneous, iodine-accelerated, thyroid autoimmunity develops in NOD.H2h4 mice associated with thyroglobulin and thyroid-peroxidase, but not TSHR, Abs. We hypothesized that transferring the human TSHR A-subunit to NOD.H2h4 mice would result in loss of tolerance to this protein. BALB/c human TSHR A-subunit mice were bred to NOD.H2h4 mice, and transgenic offspring were repeatedly backcrossed to NOD.H2h4 mice. All offspring developed Abs to thyroglobulin and thyroid-peroxidase. However, only TSHR-transgenic NOD.H2h4 mice (TSHR/NOD.H2h4) developed pathogenic TSHR Abs as detected using clinical Graves’ disease assays. As in humans, TSHR/NOD.H2h4 female mice were more prone than male mice to developing pathogenic TSHR Abs. Fortunately, in view of the confounding effect of excess thyroid hormone on immune responses, spontaneously arising pathogenic human TSHR Abs cross-react poorly with the mouse TSHR and do not cause thyrotoxicosis. In summary, the TSHR/NOD.H2h4 mouse strain develops spontaneous, iodine-accelerated, pathogenic TSHR Abs in female mice, providing a unique model to investigate disease pathogenesis and test novel TSHR Ag-specific immunotherapies aimed at curing Graves’ disease in humans.
School environment, socioeconomic status and weight of children in Bloemfontein, South Africa
Authors: Meko Lucia N.M. , Slabber-Stretch Marthinette , Walsh Corinna M. , Kruger Salome H. , Nel Mariette 
Published: April 2015

Background: The continued existence of undernutrition, associated with a steady increase in the prevalence of overweight and obesity in children and adolescents, necessitates identification of factors contributing to this double burden of disease, in order for effective treatment and prevention programmes to be planned.Aim: To determine the nutritional status of 13–15-year-old children in Bloemfontein and its association with socioeconomic factors.Setting: Bloemfontein, Free State Province, South Africa (2006).Methods: This was a cross-sectional analytical study. Randomly selected children (n = 415) completed structured questionnaires on socioeconomic status. The children’s weight and height were measured and body mass index-for-age and height-for-age z-scores were computed according to World Health Organization growth standards in order to determine the prevalence of underweight, overweight, obesity and stunting. Waist circumference was measured to classify the children as having a high or very high risk for metabolic disease.Results: Of the 415 children who consented to participate in the study, 14.9% were wasted and 3.4% were severely wasted. Only 6% of the children were overweight/obese. Significantly more boys (23.0%) were wasted than girls (10%) and severe stunting was also significantly higher in boys than in girls (10.3% and 4.2%, respectively). Children whose parents had graduate occupations were significantly more overweight/obese than those with parents working in skilled occupations. Stunting was significantly higher in low (31.4%) and medium (30.4%) socioeconomic groups compared to the high socioeconomic group (18.1%).Conclusion: A coexistence of underweight and overweight was found and gender and parental occupation were identified as being predictors of nutritional status.
‘If you have a problem with your heart, you have a problem with your life’: Self-perception and behaviour in relation to the risk of ischaemic heart disease in people living with HIV
Authors: Roos Ronel , Myezwa Hellen , Van Aswegen Helena 
Published: April 2015

Background: Ischaemic heart disease (IHD) is a global health problem and specifically relevant in the African context, as the presence of risk factors for IHD is increasing. People living with the human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) (PLWHA) are at increased risk for IHD due to increased longevity, treatment-specific causes and viral effects.Aim: To determine the self-perception and behaviour in relation to risk for IHD in a cohort of South African PLWHA.Methods:A qualitative study using semi-structured interviews with a card-sort technique was used to gather data from 30 individuals at an HIV clinic in Johannesburg. Descriptive analysis and conventional content analysis were done to generate the findings.Results: The median age of the cohort was 36.5 (31.8–45.0) years and they were mostly women (n = 25; 83.3%) who were employed (n = 17; 56.7%) and supporting dependents (n = 26; 86.7%). Fifteen (50%) participants did not perceive themselves at risk of IHD and reported having adequate coping behaviour, living a healthy lifestyle and being healthy since initiating therapy. Twelve (40%) did feel at risk because they experienced physical symptoms and had poor behaviour. Knowledge and understanding related to IHD, insight into own risk for IHD and health character in a context of HIV infection were three themes.Conclusion: This study highlights that participants did not perceive themselves to be at risk of IHD due to their HIV status or antiretroviral management. Education strategies are required in PLWHA to inform their personal risk perception for IHD.
Rural Zulu women’s knowledge of and attitudes towards medical male circumcision
Authors: Ikwegbue Joseph N. , Ross Andrew , Ogbonnaya Harbor 
Published: April 2015

Background: Medical male circumcision (MMC) is a key strategy in the South African HIV infection prevention package. Women may have a potentially powerful role in supporting such a strategy. Circumcision is not a traditional part of Zulu society, and Zulu women may have limited knowledge and ambivalent or negative attitudes towards MMC.Aim: This study employs quantitative data to expand insight into rural Zulu women’s knowledge of and attitudes towards MMC, and is important as women could potentially yield a powerful positive or negative influence over the decisions of their partners and sons.Setting: A hospital-based antenatal clinic in rural KwaZulu-Natal.Methods: Participants were 590 pregnant, mostly isiZulu-speaking women. Data on their knowledge of and attitude towards MMC were collected using a questionnaire and were analysed descriptively.Results: The majority of the women supported MMC; however, knowledge of the potential benefits was generally poor. Most would encourage their partners and sons to undergo MMC. The preferred place for the procedure was a hospital.Conclusion: Zulu participants supported MMC and would support their partners and children being circumcised. Knowledge around potential benefits was worryingly poor, and further research into disseminating information is essential. The findings highlight the need for an expanded campaign of health education for women, and innovative means are suggested to enhance information accessibility. Reasons for preferring that MMC be carried out in hospital need to be explored further.
Risk factors of community-associated infections in Chinese patients with diabetes: A meta-analysis
Authors: Zhao Guang-Dan , Sun Jia-Ying , Zhao Ming-Jing , Wang Ling-Ling , Li Fang-Zhi , Liu Shuo , Liu Dan , Wang Xiao-Ge 
Published: April 2015

Abstract
Objective: To identify the common sites and risk factors of community-associated infections in Chinese patients with diabetes. Materials and Methods: The Wanfang, CNKI, PUBMED and VIP databases restricting to Chinese patients with diabetes were queried without restriction to time period. Randomized controlled trials (RCTs) on the risk factors of community-associated infections in Chinese patients with diabetes were considered. Polled odd ratios (OR) and 95% confidence intervals (95% CI) were used for each factor in fixed or random-effect metaanalyses. Results: Twelve studies were identified that investigated seven risk factors of community-associated infections in Chinese patients with diabetes. The average infection incidence was 39.55%. The respiratory tract and urology tract were the predilection sites. Meta-analysis results are as follows: Diabetic patients with chronic complications (OR: 1.63; 95% CI 1.45-1.82), advanced age (OR: 1.30; 95% CI 1.19-1.42), longer duration (OR: 1.47; 95% CI 1.35-1.61) or ketoacidosis (OR: 1.37; 95% CI 1.13-1.66) were more prone to suffer from infections. Those with better glycemic control (OR: 0.68; 95% CI 0.61-0.76) or males (OR: 0.69; 95% CI 0.64-0.75) were less prone to suffer from infections. Conclusion: Chinese patients with diabetes had a high incidence of community-associated infections. We should highlight the risk factors that might provide a reference for the same.
Higher Moments of Fourier Coefficients of Cusp Forms
Authors: Lü Guangshi , Sankaranarayanan Ayyadurai 
Published: April 2015

AbstractLet Sk(Γ) be the space of holomorphic cusp forms of even integral weight k for the full modular group SL(z, ℤ). Let be the n-th normalized Fourier coefficients of three distinct holomorphic primitive cusp forms , and h(z) ∊ Sk3 (Γ), respectively. In this paper we study the cancellations of sums related to arithmetic functions, such as twisted by the arithmetic function λf(n).
Bridging the Gap
Authors: Clements K. , Garrie R.L. , Houser S.H. , Berner E.S , Dorsey A.D. 
Published: April 2015

SummaryBackground: Health Information Management (HIM) and Health Informatics (HI) were very separate professions when they were first formed. However, with the increasing adoption of electronic health records, the interests of the two fields have become more aligned.Objectives: To describe the evolution of a joint master’s program in health informatics(HI) and health information management (HIM)Methods: After analyzing workforce needs, and reviewing both CAHIIM accreditation requirements and existing curricular offerings in separate programs in HIM and HI, a joint program was developed.Results: An HI master’s program with a core curriculum for all students and tracks in Data Analytics, User Experience and Advanced Practice HIM was developed. A model for a comprehensive examination, based on the CAHIIM competencies, to be administered prior to and after the core curriculum was also developed.Conclusions: A core and track curriculum that incorporates HIM education as part of the Master of Science of Health Informatics provides a feasible roadmap for the future as HIM and HI become more closely aligned.Citation: Dorsey AD, Clements K, Garrie RL, Houser SH, Berner ES. Bridging the gap – a collaborative ppproach to health information management and informatics education. Appl Clin Inf 2015; 6: 211–223http://dx.doi.org/10.4338/ACI-2014-09-RA-0083
“The Tongue”:
Authors: Lerer Seth 
Published: April 2015

Abstract
This article argues that the assembly of stanzas in the Findern manuscript known as “The Tongue” presents a coherent, voiced, lyric poem made up of selections from Lydgate's Fall of Princes, Chaucer's Troilus and Criseyde, and a concluding stanza unique to this manuscript. I illustrate how the Findern scribe recast this source material into a poem that resonates with the broad concerns of the manuscript as a whole: the place of proper speech in social behavior, the relationships of male and female eloquence, and the allegorizations of courtly gaming adapted to a gentry world. More pointedly, the poem's final stanza, with its reference to marking the chase in the game of tennis, associates its idioms with the personal allegories of Charles d'Orléans, and I suggest that the overall tone and texture of this poem owes much to Charles's literary sensibility as it was understood in late-fifteenth-century England.
ISÓCRATES E O IDEAL PAN-HELÊNICO: UM DISCURSO DE UNIÃO NO SÉCULO IV A.C.
Authors: Felisbino Luciane 
Published: April 2015

Este artigo tem por objetivo pensar a questão da identidade grega durante o século IV a.C., através de um dos discursos escritos por Isócrates, o Panegírico. Partindo da questão da independência política das póleis, procuro entender quais então seriam os elementos agregadores destes grupos, tentando perceber a partir de Isócrates, as relações entre as cidades gregas, principalmente Atenas e Esparta, e também entre elas e os persas.
“PARA LIVRAR DE TODO CATIVEIRO E PERSEGUIÇÃO”: LIBERDADE DE ESCRAVOS ATRAVÉS DE CARTAS DE ALFORRIA EM LARANJEIRAS, SERGIPE (1843-1881)
Authors: Bezerra Luiz Paulo Santos 
Published: April 2015

No presente texto, pretende-se fazer uma análise descritiva de um conjunto de cartas de alforria registradas nos Livros de Notas de Laranjeiras, Sergipe, durante os períodos de 1843 a 1881. Esses registros de liberdade nos fornecem dados importantes sobre os escravos e senhores que viveram na zona do Cotinguiba, mais precisamente em Laranjeiras, onde o seu desenvolvimento econômico foi de grande relevância para Sergipe. Os resultados encontrados nesta pesquisa são parciais, pois, para uma melhor compreensão será necessário ainda, um cruzamento de outras fontes como, os inventários e testamentos post-mortem da mesma localidade. Dialogamos ainda com vários autores que tratam do mesmo temaem outras regiões do Brasil.
REFLEXÕES SOBRE A HISTÓRIA SOCIAL DAS MULHERES NA ANTIGUIDADE TARDIA: O CASO DAS DEVOTAS CRISTÃS
Authors: Furlani João Carlos 
Published: April 2015

Neste artigo, temos por objetivo refletir sobre a representação e as condições sociais em que se encontravam as mulheres entre o final do século III ao início do século V no Império Romano. Para tanto, discutiremos, num primeiro momento, o conceito de Antiguidade Tardia, bem como o contexto histórico da época; para, num segundo momento, analisarmos o papel desempenhado pelas mulheres cristãs na sociedade romana. Nesse sentido, acreditamos ser possível situar personagens femininas, que mesmo diante da repreensão atribuída às suas figuras, de certo modo, destacaram-se e tiveram voz em seu tempo.
TRAJETÓRIA DE UM PATRÍCIO: CONHECENDO RIZKALLAH JORGE TAHAN E A CONSTRUÇÃO DE SEU PODER SIMBÓLICO
Authors: Geraissati Renata 
Published: April 2015

O artigo pretende reconstruir a trajetória de um expoente imigrante sírio-libanês com ascendência armênia Rizkallah Jorge Tahan (1868-1949), tendo como foco a construção de seu poder simbólico dentro das comunidades que frequentou na cidade de São Paulo. Ao desembarcar no porto de Santos em 1895 fugiu da trajetória da maioria dos imigrantes desta nacionalidade que se tornavam mascates ao chegarem no Brasil. Rizkallah trabalhou com a fundição de cobre, algo que já fazia em sua terra natal. Após três anos na capital paulista inaugurou a Casa da Boia, balcão comercial baseado no comércio de elementos como “a boia sanitária”– o que permitiu seu enriquecimento e, o consequente investimento em uma série de obras nos centros “velho” e “novo” de São Paulo.
UM MUNDO DE POSSIBILIDADES: A PENÍNSULA IBÉRICA NO SÉCULO XI
Authors: Granella Camila Flores 
Published: April 2015

O presente artigo tem por objetivo esclarecer os elementos contextuais formadores de uma nova realidade religiosa, cultural, política, social e econômica em Al-Andaluz no século XI – período subsequente ao desmantelamento de um núcleo de poder centrado em Córdoba. O foco da análise será o reino taifa de Sevilha e as trajetórias de al-Mu’tamid – terceiro governante da dinastia abbadita – e o poeta Ibn Ammâr, problematizando, dessa forma, seus contextos micro-histórico, internamente ao reino, e macro, na Península Ibérica e no mundo muçulmano.
A PERPETUAÇÃO DA MPB NA BANDA ENGENHEIROS DO HAWAII (1984 – 2009)
Authors: Baroni Lana Beatriz 
Published: April 2015

Diferentemente do que acreditam certos estudiosos do assunto, a tradição da MPB não se limitou à própria Música Popular Brasileira e, principalmente, não entrou em decadência no início da década de 1980, mas foi recuperada e apropriada por grupos musicais brasileiros no período após a Ditadura Civil Militar. Fazendo uma análise da banda gaúcha Engenheiros do Hawaii, tanto da formação de sua banda e da utilização que faz de instrumentos quanto de suas músicas, na composição e na letra, este artigo pretende apresentar a análise e os resultados obtidos na aproximação ou afastamento do grupo musical em questão à tradição da Música Popular Brasileira de forma ampla. Foco, então, nas letras de suas canções, produzidas desde sua formação, em 1984, até o lançamento de seu último álbum, em 2009, para exemplificar tais comparações.
DO LADO DE CÁ DO RIO URUGUAI: PRÁTICAS NOMINATIVAS E INSERÇÃO SOCIAL DE INDÍGENAS EM RIO PARDO (RS, 1758-1765)
Authors: Costa Alysson De Ávila 
Published: April 2015

Este artigo estuda as práticas de nominação de índios oriundos das reduções jesuíticas dos Sete Povos das Missões, através de registros batismais da freguesia de Nossa Senhora do Rosário de Rio Pardo, no atual território do Rio Grande do Sul, entre 1758 e 1765. O levantamento sistemático das informações contidas em tais registros permitiu verificar certas peculiaridades dessa população na escolha dos nomes de seus batizandos, fazendo com que o resultado dessa pesquisa contrastasse com levantamentos semelhantes para outras populações da América portuguesa colonial. Parte-se disso para se pensar a relação entre portugueses, espanhóis e índios e suas práticas sociais, religiosas e culturais em meados do século XVIII.
GÊNERO, MASCULINIDADES E ALCOOLISMO: BRASIL NO INÍCIO DO SÉCULO XX
Authors: Savian Zulemar Augusta Girotto 
Published: April 2015

A presente pesquisa tem como objetivo analisar, em uma perspectiva das relações de gênero, os discursos masculinos vinculados ao consumo de álcool no Brasil, no inicio do século XX. Através de pesquisa bibliográfica e da análise de propagandas de cerveja da época, busca-se compreender a relação entre a definição de masculinidade e o consumo de bebida alcoólica, e como foi possível a emergência das cervejarias brasileiras em um momento em que o consumo alcoólico passava a ser considerado um problema social e de saúde pública, sob o controle do Estado e do saber médico. O intenso debate sobre a questão do consumo excessivo de bebidas alcoólicas, posto naquele momento, fez com que os fabricantes de cerveja investissem em um novo significado de consumo, distante daquele condenado, na busca do consumidor, em particular, o masculino, das classes mais abastadas. As imagens projetadas nas propagandas estabelecem um perfil idealizado de masculinidade vinculado à elite do sudeste brasileiro, distinto daquele relacionado às classes mais pobres urbanas e vinculado a problemas sociais.
LE GOFF, Jaques. A bolsa e a vida: a usura na Idade Média. 3 ed. São Paulo: Brasiliense, 2004.
Authors: Pires Kassia Amariz , Costa Natália De Medeiros 
Published: April 2015

Resenha de LE GOFF, Jaques. A bolsa e a vida: a usura na Idade Média. 3 ed. São Paulo: Brasiliense, 2004.
Rechter brengt balans aan in onevenwichtige bestuurlijke boete
Authors: Mein Arnt 
Published: April 2015

Rechter brengt balans aan in onevenwichtige bestuurlijke boete
Op 24 november 2014 heeft de Centrale Raad van Beroep (CRvB) een uitspraak gedaan over een door het UWV opgelegde bestuurlijke boete wegens overtreding van de zogenoemde inlichtingenverplichting van artikel 25 van de Werkloosheidswet (WW). De uitspraak is interessant omdat de rechter het tamelijk rigide boetestelstel voor de SZW-wetgeving aanzienlijk verruimt.
Trends in Market Access for Specialty Biologics: Challenges & Promises
Authors: Rao Sanjay Kumar 
Published: April 2015

Specialty biologics are the fastest growing class of bio/pharmaceutical products in terms of the number of new brand launches and rates of health care spending in the U.S. and globally. Innovative biologics meant to treat a range of hitherto untreatable conditions in oncology, inflammation, CNS, endocrinology and other chronic conditions seek to offer radical improvements in efficacy and patient well-being. Such products can command premium prices, often costing over $100K per year per patient - triggering a raft of challenges to ensuring that eligible patients have adequate access.Â This article outlines important trends impacting market access to specialty biologics in the U.S. and globally. Particular importance is placed on evolving methods for managing specialty product utilization and reimbursement toward ensuring appropriate access. The reshaping of the specialty product market access landscape in the U.S. through the availability of oral biologic formulations distributed to patients via high-touch, high-involvement specialty pharmacies is examined. The rising role of risk sharing between specialty product manufacturers and insurers as a way to balance rewards of access with the risks inherent in radical new specialty therapeutics is discussed. Challenges posed by specialty biosimilars to traditional ways of ensuring market access and fair reimbursement are outlined. The impact of health care reforms on market access for specialty biologics in the U.S. is discussed in the context of the growing need for comparative outcomes research and the application of the principles of health technology assessments - adapted, in part from their apparent success in ensuring equitable and cost-effective access to biologics in the E.U.
The University of Colorado Certificate Program in Bioinnovation and Entrepreneurship: An Update and Current Status
Authors: Parthasarathy Madhavan , Forlani David , Meyers Arlen 
Published: April 2015

The purpose of this paper is to provide an update and report the current status of the cross-campus University of Colorado Denver program in bioinnovation and entrepreneurship, details of which were first reported in the Journal of Commercial Biotechnology in 20125.Â The paper outlines the joys and challenges of implementing an inter-campus program that attempts to marry cutting-edge biotechnology innovation with a solid business foundation.Â The tremendous value offered by such a program, particularly to biotechnology and life-science researchers, is outlined. Operationalization and process issues such as differential tuition rates, distance between campuses, and class timing issues are considered, and solutions are offered.Â Â Finally, recommendations are provided for other business schools considering a similar program.