bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL-1β-Specific Up-Regulation of Neutrophil Gelatinase-Associated Lipocalin Is Controlled by IκB-ζ
Authors: Cowland Jack B. , Muta Tatsushi , Borregaard Niels 
Published: April 2014

Abstract
Neutrophil gelatinase-associated lipocalin (NGAL) is a siderophore-binding protein that exerts a bacteriostatic effect by sequestering iron. Strong induction of NGAL synthesis has been observed in inflamed epithelium of the lungs and colon. Expression of NGAL is up-regulated in the lung epithelial cell line A549 by IL-1β, but not by TNF-α, despite an induction of NF-κB binding to the NGAL promoter by both cytokines. In this study, we present evidence that the IL-1β specificity is caused by a requirement of the NGAL promoter for the NF-κB-binding cofactor IκB-ζ for transcriptional activation. Up-regulation of NGAL expression in A549 cells following IL-1β stimulation was dependent on de novo protein synthesis and was greatly diminished by a small interfering against IκB-ζ mRNA. Cotransfection of A549 cells with a plasmid expressing IκB-ζ made TNF-α capable of inducing NGAL transcription, indicating that IκB-ζ induction is the only factor discriminating between IL-1β and TNF-α in their ability to induce NGAL expression. Coexpression of the cofactor Bcl-3, which is closely related to IκB-ζ, did not enable TNF-α to induce NGAL transcription. A functional NF-κB site of the NGAL promoter was required for IκB-ζ to exert its effect. The human β defensin 2 gene also required IκB-ζ for its IL-1β-specific induction in A549 cells. Our findings indicate that a common regulatory mechanism has evolved to control expression of a subset of antimicrobial proteins expressed in epithelial cells.
Mast Cell-Mediated Remodeling and Fibrinolytic Activity Protect against Fatal Glomerulonephritis
Authors: Kanamaru Yutaka , Scandiuzzi Lisa , Essig Marie , Brochetta Cristiana , Guérin-Marchand Claudine , Tomino Yasuhiko , Monteiro Renato C. , Peuchmaur Michel , Blank Ulrich 
Published: April 2014

AbstractMast cells are detrimental in several inflammatory diseases; however, their physiological roles are also increasingly recognized. Recent data suggest that mast cells may also be involved in renal diseases. We therefore used congenitally mast cell-deficient W/Wv mice and normal +/+ littermates to assess their role in anti-glomerular basement membrane-induced glomerulonephritis. Following administration of anti-glomerular basement membrane Abs, W/Wv mice exhibited increased mortality as compared with +/+ mice owing to rapid deterioration of renal function. Reconstitution of the mast cell population in W/Wv mice restored protection. This was independent of activating FcγR, as protection was also obtained using mast cells deficient in FcRγ. Comparative histological analysis of kidneys showed that deterioration of renal function was caused by the presence of thick layers of subendothelial glomerular deposits in W/Wv mice, while +/+ mice or mast cell-reconstituted W/Wv mice showed significantly less. Deposits appeared during the early phase of disease and persisted thereafter, and were accompanied by enhanced macrophage recruitment. Immunohistochemical analysis revealed increased amounts of fibrin and type I collagen in W/Wv mice, which were also unable to maintain high tissue plasminogen activator and urinary-type plasminogen activator activity in urine in the heterologous phase of disease. Our results indicate that mast cells by their ability to mediate remodeling and repair functions are protective in immune complex-mediated glomerulonephritis.
Approximate Fixed Point Sequences of Nonlinear Semigroups in Metric Spaces
Authors: Khamsi M. A. 
Published: April 2014

AbstractIn this paper, we investigate the common approximate fixed point sequences of nonexpansive semigroups of nonlinear mappings {T1}t≥0, i.e., a family such that T0(x) = x, Ts+t = Ts(Tt(x)), where the domain is a metric space (M; d). In particular, we prove that under suitable conditions the common approximate fixed point sequences set is the same as the common approximate fixed point sequences set of two mappings from the family. Then we use the Ishikawa iteration to construct a common approximate fixed point sequence of nonexpansive semigroups of nonlinear mappings.
A Remember-Know Analysis of the Semantic Serial Position Function
Authors: Kelley Matthew R. , Neath Ian , Surprenant Aimée M. 
Published: April 2014

Abstract
Did the serial position functions observed in certain semantic memory tasks (e.g., remembering the order of books or films) arise because they really tapped episodic memory? To address this issue, participants were asked to make "remember-know" judgments as they reconstructed the release order of the 7 Harry Potter books and 2 sets of movies. For both classes of stimuli, the "remember" and "know" serial position functions were indistinguishable, and all showed the characteristic U-shape with marked primacy and recency effects. These results are inconsistent with a multiple memory systems view, which predicts recency effects only for "remember" responses and no recency effects for "know" responses. However, the data were consistent with a general memory principle account: the relative distinctiveness principle. According to this view, performance on both episodic and semantic memory tasks arises from the same type of processing: Items that are more separated from their close neighbors in psychological space at the time of recall will be better remembered.
Correction of False Memory for Associated Word Lists by Collaborating Groups
Authors: Weigold Arne , Russell Elizabeth J. , Natera Sara N. 
Published: April 2014

Abstract
Collaborative inhibition is often observed for both correct and false memories. However, research examining the mechanisms by which collaborative inhibition occurs, such as retrieval disruption, reality monitoring, or group filtering, is lacking. In addition, the creation of the nominal groups (i.e., groups artificially developed by combining individuals’ recall) necessary for examining collaborative inhibition do not use statistical best practices. Using the Deese-Roediger- McDermott paradigm, we examined percentages of correct and false memories in individuals, collaborative interactive groups, and correctly created nominal groups, as well as the processes that the collaborative interactive groups used to determine which memories to report. Results showed evidence of the collaborative inhibition effect. In addition, analyses of the collaborative interactive groups’ discussions found that these groups wrote down almost all presented words but less than half of nonpresented critical words, after discussing them, with nonpresented critical words being stated to the group with lower confidence and rejected by other group members more often. Overall, our findings indicated support for the group filtering hypothesis.
The Phenomenology of Lucid Dreaming: An Online Survey
Authors: Stumbrys Tadas , Erlacher Daniel , Johnson Miriam , Schredl Michael 
Published: April 2014

Abstract
In lucid dreams the dreamer is aware that he or she is dreaming. Although such dreams are not that uncommon, many aspects of lucid dream phenomenology are still unclear. An online survey was conducted to gather data about lucid dream origination, duration, active or passive participation in the dream, planned actions for lucid dreams, and other phenomenological aspects. Among the 684 respondents who filled out the questionnaire, there were 571 lucid dreamers (83.5%). According to their reports, lucid dreams most often originate spontaneously in adolescence. The average lucid dream duration is about 14 minutes. Lucid dreamers are likely to be active in their lucid dreams and plan to accomplish different actions (e.g., flying, talking with dream characters, or having sex), yet they are not always able to remember or successfully execute their intentions (most often because of awakening or hindrances in the dream environment). The frequency of lucid dream experience was the strongest predictor of lucid dream phenomenology, but some differences were also observed in relation to age, gender, or whether the person is a natural or self-trained lucid dreamer. The findings are discussed in light of lucid dream research, and suggestions for future studies are provided.
Explaining the Gender Difference in Nightmare Frequency
Authors: Schredl Michael 
Published: April 2014

Abstract
A recent meta-analysis showed a robust gender difference in nightmare frequency of medium effect size in adolescents and young adults: Women tend to report nightmares more frequently than men. The present study, carried out in an unselected student sample, indicates that 2 factors mediate the gender difference in nightmare frequency: neuroticism and overall dream recall frequency. The effect of neuroticism on the gender difference and the finding that the gender difference in nightmare frequency emerges at an age of about 10 years suggest that genderspecific socialization processes may play an important role in explaining the gender differences in nightmare frequency in adolescents and young to middle-aged adults. This idea is supported by the previous finding that nightmare frequency is related to sex role orientation. However, longitudinal studies are necessary to validate these hypotheses.
Exploratory and Confirmatory Factor Analyses of Probability Discounting of Different Outcomes Across Different Methods of Measurement
Authors: Terrell Heather K. , Derenne Adam , Weatherly Jeffrey N. 
Published: April 2014

Abstract
The present studies used exploratory and confirmatory factor analyses to explore the degree to which probability discounting processes are similar to delay discounting processes. To determine whether these processes are similar, 2 questions were addressed: the degree to which probability discounting outcomes can be categorized into multiple domains (as demonstrated for delay discounting) and whether the inverse magnitude effect would be observed for nonmonetary outcomes. An exploratory factor analysis was conducted using data from the fill-in-the-blank method (Study 1), followed by a confirmatory factor analysis using data from a multiple-choice method (Study 2) as a replication. These studies provide support for the idea that outcomes can be subdivided into multiple domains. Generally, the discounting rates were steeper for tangible outcomes than nontangible outcomes, and a magnitude effect was observed that was consistent with, rather than the inverse of, that observed for delay discounting tasks. Complexities related to the relationship between probability discounting processes and delay discounting processing are discussed.
Somatic Dysfunction and Use of Osteopathic Manual Treatment Techniques During Ambulatory Medical Care Visits: A CONCORD-PBRN Study
Authors: Licciardone John C. , Kearns Cathleen M. , King Hollis H. , Seffinger Michael A. , Crow W. Thomas , Zajac Peter , Devine William H. , Abu-Sbaih Reem Y. , Miller Stephen J. , Berkowitz Murray R. , Dyer Robin , Heath Deborah M. , Treffer Kevin D. , Nevins Natalie A. , Aryal Subhash 
Published: April 2014

Abstract

Context: Osteopathic manual treatment (OMT) of somatic dysfunction is a unique approach to medical care that may be studied within a practice-based research network.

Objective: To measure patient characteristics and osteopathic physician practice patterns within the Consortium for Collaborative Osteopathic Research Development–Practice-Based Research Network (CONCORD-PBRN).

Design: Cross-sectional card study.

Setting: Eleven member clinics within the CONCORD-PBRN coordinated by The Osteopathic Research Center.

Patients: A total of 668 patients seen between January and March 2013.

Main Study Measures: Patient age and sex; primary diagnoses; somatic dysfunction as manifested by tenderness, asymmetry, restricted motion, or tissue texture changes; and use of 14 OMT techniques. Results were stratified by anatomical region and adjusted for clustering within member clinics. Clustering was measured by the intracluster correlation coefficient.

Results: Patient ages ranged from 7 days to 87 years (adjusted mean age, 49.2 years; 95% confidence interval [CI], 43.3-55.1 years). There were 450 females (67.4%) and 508 patient visits (76.0%) involved a primary diagnosis of disease of the musculoskeletal system and connective tissue. Structural examination was performed during 657 patient visits (98.4%), and 649 visits (97.2%) involved OMT. Restricted motion and tenderness were the most and least common palpatory findings, respectively. Cranial (1070 [14.5%]), myofascial release (1009 [13.7%]), muscle energy (1001 [13.6%]), and counterstrain (980 [13.3%]) techniques were most commonly used, accounting for more than one-half of the OMT provided. Pediatric patients were more likely than adults to receive OMT within the head (adjusted odds ratio [OR], 9.53; 95% CI, 1.28-71.14). Geriatric patients were more likely than adults to receive a structural examination (adjusted OR, 1.83; 95% CI, 1.09-3.07) and OMT (adjusted OR, 1.62; 1.02-2.59) within the lower extremity. Females were more likely than males to receive a structural examination (adjusted OR, 2.44; 95% CI, 1.44-4.16) and OMT (adjusted OR, 2.11; 95% CI, 1.26-3.52) within the sacrum and OMT within the pelvis (adjusted OR, 1.79; 95% CI, 1.12-2.88). Intracluster correlation coefficients for the 4 most commonly used OMT techniques ranged from 0.34 to 0.72.

Conclusion: This study provides proof of concept of the feasibility of studying osteopathic medical practice on a national level by developing and growing the CONCORD-PBRN.
Association of Low Back Pain, Somatic Dysfunction, and Lumbar Bone Mineral Density: Reproducibility of Findings
Authors: Snider Karen T. , Johnson Jane C. , Degenhardt Brian F. , Snider Eric J. , Burton Douglas C. 
Published: April 2014

Abstract

Context: Somatic dysfunction as diagnosed by palpation should be associated with an objective measure. Bone mineral density (BMD) has been shown to be elevated in lumbar vertebrae with somatic dysfunction and in the lumbar region of individuals with chronic low back pain (LBP).

Objective: To investigate the association of lumbar somatic dysfunction and BMD T-score variability in participants with chronic LBP and without LBP (non-LBP) and to determine the reproducibility of previously published results.

Methods: Two examiners, blinded to symptom history, evaluated participants for tissue texture abnormalities, rotational asymmetry, anterior motion restriction, and tenderness at vertebral levels L1 to L4. Participants also underwent dual-energy x-ray absorptiometry of vertebral levels L1 to L4 for the assessment of BMD T scores. Generalized linear models were used to compare the chronic LBP and non-LBP groups on the presence and severity of somatic dysfunction and to test whether group and the presence and severity of somatic dysfunction were related to BMD T scores.

Results: Forty-three chronic LBP (54%) and 36 non-LBP participants (46%) completed the study. Although the presence of somatic dysfunction in the 2 groups was not significantly different, the presence of tenderness was significantly more common in the chronic LBP group (P<.001), as was the severity for tissue texture abnormalities (P=.03), motion restriction (P=.04), and tenderness (P<.001). Of the 316 vertebrae assessed, 31 (10%, all in the chronic LBP group) had moderate/severe tenderness. The vertebral somatic dysfunction burden score, the total somatic dysfunction burden score, the vertebral somatic dysfunction severity score, and the total somatic dysfunction severity score were higher in the chronic LBP group (all P<.001). The vertebral BMD T score was significantly higher for vertebrae demonstrating moderate/severe rotational asymmetry compared with those demonstrating mild or no rotational asymmetry (P=.01) and for vertebrae demonstrating moderate/severe tenderness compared with those demonstrating no tenderness (P=.04).

Conclusion: Study results suggest that somatic dysfunction was more significant in chronic LBP participants. Although the correlation between the presence of somatic dysfunction and segmental BMD T scores was not reproduced, BMD T scores were higher for vertebrae demonstrating moderate/severe rotational asymmetry and tenderness.
Management of Ionizing Radiation Injuries and Illnesses, Part 2: Nontherapeutic Radiologic/Nuclear Incidents
Authors: Christensen Doran M. , Parillo Steven J. , Glassman Erik S. , Sugarman Stephen L. 
Published: April 2014

Abstract
In the second of 5 articles on the management of injuries and illnesses caused by ionizing radiation, the authors discuss nontherapeutic radiologic/nuclear incidents: use of a radiologic exposure device, use of a radiologic dispersal device, nuclear power plant safety failure, and detonation of an improvised nuclear device. The present article focuses on how such incidents—whether involving deliberate or accidental methods of radiation exposure—produce casualties and how physicians need to understand the pathologic process of injuries caused by these incidents. To identify the diagnoses associated with nontherapeutic exposure in time to improve morbidity and mortality, physicians must maintain a high index of suspicion when faced with a specific constellation of symptoms. In some scenarios, the sheer number of uninjured, unaffected persons who might present to health care institutions or professionals may be overwhelming. Public health and safety issues may seriously disrupt the ability to respond to and recover from a radiologic and nuclear incident, especially a nuclear detonation.
Pi2 pulsation simultaneously observed in the E and F region ionosphere with the SuperDARN Hokkaido radar
Authors: Teramoto M. , Nishitani N. , Pilipenko V. , Ogawa T. , Shiokawa K. , Nagatsuma T. , Yoshikawa A. , Baishev D. , Murata K. T. 
Published: April 2014

AbstractWe investigated Pi2 pulsations in the nightside ionosphere that began at 14:15 UT (2315 LT) on 11 July 2010, and they were observed with high‐temporal (8 s) resolution by beam 4 of the Super Dual Auroral Radar Network (SuperDARN) Hokkaido radar. These pulsations were simultaneously observed in both the ground/sea scatter echoes reflected from the F region height and in ionospheric echoes from field‐aligned irregularities in the sporadic Es region. They had the same period of 110 s and approximately no phase lag. From the radar observations and the International Geomagnetic Reference Field model, the amplitude of the eastward (EEW) component of the electric field of the Pi2 pulsations in the ionosphere was estimated ~8.0 mV/m in the F region and ~2.0 mV/m in the E region. Corresponding Pi2 pulsations appeared dominantly in the horizontal northward magnetic field component (H) at nearby ground stations, Moshiri (MSR), St. Paratunka (PTK), and Stecolny (STC), with amplitudes ranging from 6 nT (MSR) to 10 nT (STC). At the dominant frequency of 8.8 mHz, the coherences between H and EEW were high (>0.9), the cross phases of EEW relative to H were −56° and −45°, and the amplitude ratios were 2.7 × 105 m/s and 8.4 × 105 m/s, in the E and F regions, respectively. Based on a comparison of these results with theoretical predictions, we suggest that the concept of a pure cavity mode is not sufficient to explain the combined observations for midlatitude Pi2 waves and that the contribution of an Alfvén waves must be taken in account.
Sensitivity of sediment geochemical proxies to coring location and corer type in a large lake: Implications for paleolimnological reconstruction
Authors: Lu Yue Han , Meyers Philip A. , Robbins John A. , Eadie Brian J. , Hawley Nathan , Ji Kang Hyeun 
Published: April 2014

AbstractWe compared a suite of geochemical proxies in sediment cores collected in 1982, 1988, 1991, and 2003 from sites near the depocenter of Lake Erie to evaluate the reliability of paleoenvironmental reconstructions derived from lacustrine sediments. Our proxies included the concentrations and carbon isotopic compositions of organic and inorganic carbon (TOC, CaCO3, δ13Corg, and δ13CCaCO3), augmented by organic C to total N ratios (Corg:Ntot), δ15N, and carbonate δ18O values (δ18OCaCO3). The three coring sites were clustered within 12 km; two types of corers—a Box corer and a Benthos gravity corer—were used for the 1991 sampling campaign. The variance of most proxies was accounted for not only by temporal environmental changes but also by coring locations and corer type, indicating that sediment spatial heterogeneity and differences in sediment recovery due to the use of different corers also played a part in determining the geochemical compositions of these cores. The TOC, δ13Corg, and δ13CCaCO3 values showed decadal temporal patterns that were consistent between the multiple sampling campaigns. In contrast, the δ15N, Corg:Ntot, CaCO3, and δ18OCaCO3 exhibited across‐core differences in their temporal variations, making it difficult to extract consistent environment information from different cores. Our findings suggest that in addition to temporal environmental changes, high‐resolution paleolimnological reconstruction is sensitive to many factors that could include spatial sediment heterogeneity, discontinuous sedimentation processes, bioturbation, sediment dating uncertainty, and artifacts associated with analytical and coring procedures. Therefore, multiple‐core sampling and analysis are important in reliably reconstructing environmental changes, particularly for large, heterogeneous lacustrine basins.
Thermogenic methane injection via bubble transport into the upper Arctic Ocean from the hydrate‐charged Vestnesa Ridge, Svalbard
Authors: Smith Andrew J. , Mienert Jürgen , Bünz Stefan , Greinert Jens 
Published: April 2014

AbstractWe use new gas‐hydrate geochemistry analyses, echosounder data, and three‐dimensional P‐Cable seismic data to study a gas‐hydrate and free‐gas system in 1200 m water depth at the Vestnesa Ridge offshore NW Svalbard. Geochemical measurements of gas from hydrates collected at the ridge revealed a thermogenic source. The presence of thermogenic gas and temperatures of ∼3.3°C result in a shallow top of the hydrate stability zone (THSZ) at ∼340 m below sea level (mbsl). Therefore, hydrate‐skinned gas bubbles, which inhibit gas‐dissolution processes, are thermodynamically stable to this shallow water depth. This was confirmed by hydroacoustic observations of flares in 2010 and 2012 reaching water depths between 210 and 480 mbsl. At the seafloor, bubbles are released from acoustically transparent zones in the seismic data, which we interpret as regions where free gas is migrating through the hydrate stability zone (HSZ). These intrusions result in vertical variations in the base of the HSZ (BHSZ) of up to ∼150 m, possibly making the shallow hydrate reservoir more susceptible to warming. Such Arctic gas‐hydrate and free‐gas systems are important because of their potential role in climate change and in fueling marine life, but remain largely understudied due to limited data coverage in seasonally ice‐covered Arctic environments.