bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: First Synthesis and Aggregation Behavior of Periconjugated Triazoliumfullerene.
Authors: Ikuma Naohiko , Inaba Saori , Kokubo Ken , Oshima Takumi 
Published: February 2014

AbstractThe target triazolium fullerene is prepared by a [3 + 2]‐cycloaddition reaction of 1,3‐diaza‐2‐azoniaallene, generated in situ, with fullerene.
ChemInform Abstract: Multicomponent Prins Cyclization from Allylsilyl Alcohols Leading to Dioxaspirodecanes.
Authors: Barbero Asuncion , Diez‐Varga Alberto , Pulido Francisco J. 
Published: February 2014

AbstractThis reaction proceeds via an acid catalyzed Sakurai reaction followed by the formation of an oxocarbenium intermediate with a second equivalent of aldehyde.
ChemInform Abstract: A Novel Synthesis of Tetrasubstituted Pyrroles via Tandem Benzylic Oxidative Cyclization.
Authors: Yavari Issa , Bayat Mohammad J. 
Published: February 2014

AbstractA tandem pseudo‐three‐component reaction of benzylamines and two equivalents of acetylenic esters is developed providing a novel synthesis of tetrasubstituted pyrroles.
ChemInform Abstract: Benzannulation via the Reaction of Ynamides and Vinylketenes. Application to the Synthesis of Highly Substituted Indoles.
Authors: Lam Tin Yiu , Wang Yu‐Pu , Danheiser Rick L. 
Published: February 2014

AbstractA two‐stage tandem strategy for the synthesis of indoles with a high level of substitution on the six‐membered ring is described.
ChemInform Abstract: Synthesis of 1,2‐Diaryl‐6,6‐dimethyl‐5,6‐dihydro‐1H‐indole‐4,7‐diones from Arylglyoxals and Enamines Through Domino Condensation and Allylic Hydroxylation.
Authors: Maity Subhendu , Pramanik Animesh 
Published: February 2014

AbstractA convenient two‐step procedure is developed for the synthesis of the title diones (IV) via reaction of enamines with arylglyoxals followed by oxidation of the indolone derivatives (III).
ChemInform Abstract: A Multistep Flow Process for the Synthesis of Highly Functionalized Benzoxazoles.
Authors: Sedelmeier Joerg , Lima Fabio , Litzler Alain , Martin Benjamin , Venturoni Francesco 
Published: February 2014

AbstractTreatment of substrates (I) with BuLi under continuous flow conditions allows to minimize the hold‐up time for the resulting unstable lithiated benzoxazole intermediates which react with various electrophiles to give the corresponding substituted benzoxazoles.
ChemInform Abstract: Rapid Synthesis of Fused Oxabicycles Through the Molecular Rearrangement of Spirocyclic Ethers.
Authors: Palmer Leoni I. , Veits Gesine K. , Read de Alaniz Javier 
Published: February 2014

Abstract5,5‐Spirocyclic cyclopentenones undergo Amberlyst‐15‐catalyzed ring opening/ring closure rearrangement to form tetrahydropyrans (II) and (IV).
ChemInform Abstract: Facile One‐Pot Green Synthesis of Some New Annulated Polyfunctionalized 2‐Amino‐4H‐pyrans
Authors: Nasiri Farough , Zolali Amin 
Published: February 2014

Abstractvia multicomponent reactions of cyclic 1,3‐dicarbonyl compounds with acetylenedicarboxylates and nitriles
ChemInform Abstract: An Efficient Isocyanide‐Based Three‐Component Diastereoselective Synthesis of Chromane‐3,4‐dicarboxamides.
Authors: Imanieh Hossein , Sarlak Mansooreh , Amanpour Tayebeh , Bazgir Ayoob 
Published: February 2014

AbstractPerforming the reaction with aliphatic amines gives only complex mixtures of numerous products.
ChemInform Abstract: Water Mediated Deprotective Intramolecular Hydroamination of N‐Propargylaminopyridines: Synthesis of Imidazo[1,2‐a]pyridines.
Authors: Mohan Darapaneni Chandra , Sarang Niraj B. , Adimurthy Subbarayappa 
Published: February 2014

AbstractA simple metal‐free protocol is developed for the title hydroamination reaction which is also successfully applied to the synthesis of imidazopyrazine derivative (IV).
ChemInform Abstract: Efficient ′One‐Pot′ Methodology for the Synthesis of Novel Tetrahydro‐β‐carboline, Tetrahydroisoquinoline and Tetrahydrothienopyridine Derivatives.
Authors: Ionescu Alexandra , Cornut Damien , Soriano Sebastien , Guissart Celine , Van Antwerpen Pierre , Jabin Ivan 
Published: February 2014

AbstractThis simple and general method gives an efficient access to the title compounds via the Pictet‐Spengler type cyclization.
ChemInform Abstract: One‐Pot Two‐Step Synthesis of 1‐(Ethoxycarbonyl)indolizines via Pyridinium Ylides.
Authors: Allgaeuer Dominik S. , Mayr Herbert 
Published: February 2014

AbstractThe reaction of readily prepared pyridinium and isoquinolinium ylides with arylidene‐malonates is investigated.
ChemInform Abstract: Nucleophilic Cyclization of 3‐Alkynylquinoxaline‐2‐carbonitriles into Pyrido[3,4‐b]quinoxalines.
Authors: Tyaglivy Alexander S. , Gulevskaya Anna V. , Pozharskii Alexander F. , Askalepova Olga I. 
Published: February 2014

AbstractTreatment of easily prepared 3‐alkynylquinoxaline‐2‐carbonitriles with an alkylamine or ammonia is shown to produce either directly previously unknown pyrido[3,4‐b]quinoxalin‐1(2H)‐imines or pyrido[3,4‐b]quinoxalin‐1‐amines via stable enamines like (VII).
ChemInform Abstract: Efficient Synthesis of Quinoxalines with Hypervalent Iodine as a Catalyst.
Authors: Chen Chung‐Yu , Hu Wan‐Ping , Liu Mei‐Chun , Yan Pi‐Cheng , Wang Jeh‐Jeng , Chung Mei‐Ing 
Published: February 2014

AbstractThe synthesis of the title compounds is realized from several internal alkynes and 1,2‐diaminobenzenes, ‐cyclohexane, and ‐pyridine in a simple one‐pot reaction without the use of transition metal catalysts.
ChemInform Abstract: CeCl3·7H2O: A Highly Efficient Catalyst for the Synthesis of 1‐Substituted‐octahydro‐[1,3,2]diazaphospholo[1,5‐a]pyridine‐1‐oxide.
Authors: Chinthaparthi Radha Rani , Gangireddy Chandra Sekhar Reddy , Mudumala Veeranarayana Reddy , Gundluru Mohan , Chamarthi Nagaraju , Cirandur Suresh Reddy 
Published: February 2014

AbstractA simple protocol is developed for the synthesis of the title compounds via Michaelis—Arbuzov reaction of diamido phosphites with various bromides.
ChemInform Abstract: New Macrocycles with Potent Antituberculosis Activity Accessed by One‐Pot Multicomponent Reactions.
Authors: Kim D. , Huang Y. , Wang K. , Doemling A. 
Published: February 2014

AbstractTylosin derivatives (III) and (VII) are synthesized by Gewald or Ugi three‐component reaction, resp., and evaluated for their antituberculosis activities.
ChemInform Abstract: Three New Hasubanan Alkaloids from Stephania hernandifolia (WILLD.) WALP
Authors: Tang Li‐Jia , Deng Lu‐Lu , He Li , Song Shao‐Hui , Zhang Jian‐Xin , Hao Xiao‐Jiang , Zhang Yuan‐Hu 
Published: February 2014

Abstractisolation, structure and cytotoxicity of three new hasubanan alkaloids, hernsubanines A—C
ChemInform Abstract: A Two‐Directional Approach to Pyrrolizidines: Total Syntheses and Biological Evaluation of Alkaloid cis‐223B (I) and (.+‐.)‐Xenovenine (II).
Authors: Barthelme Alexandre , Richards David , Mellor Ian R. , Stockman Robert A. 
Published: February 2014

AbstractBoth the natural alkaloids display the expected neurotoxic properties.
ChemInform Abstract: Concise Synthesis of (+)‐Serinolamide A.
Authors: Gao Ya‐Ru , Guo Shin‐Hua , Zhang Zhuan‐Xiang , Mao Shuai , Zhang Yan‐Lei , Wang Yong‐Qiang 
Published: February 2014

AbstractThe first total synthesis of compound (I) in nine steps with 30% overall yield is presented.
Disparity in perceptions of disease characteristics, treatment effectiveness, and factors influencing treatment adherence between physicians and patients with myelodysplastic syndromes
Authors: Steensma David P. , Komrokji Rami S. , Stone Richard M. , List Alan F. , Garcia‐Manero Guillermo , Huber John M. , Dennison Betsy , Sekeres Mikkael A. 
Published: February 2014

BACKGROUNDPrevious studies have suggested that many patients with myelodysplastic syndromes (MDS) have an incomplete understanding of their disease, which may influence adherence to prescribed regimens and outcomes.METHODSTo better understand physician and patient perceptions about MDS and MDS therapy, the authors conducted 2 surveys in February 2012: 1 for patients with MDS and 1 for health care professionals (HCPs) who cared for patients with MDS. Patient and HCP surveys consisted of 57 and 49 questions, respectively, assessing understanding of MDS, perceptions of specific treatments, barriers to treatment adherence, and treatment experience.RESULTSIn total, 477 complete patient responses and 120 complete HCP responses were received. Among patient responders, 63% were aged ≥60 years, and 42% had received at least 1 disease‐modifying therapy. Of the 61 physician responders, 57% practiced in an academic setting, and 43% practiced in the community; 71% of the 59 nonphysician HCPs worked in the community setting. Only 10% of patients agreed that MDS represented “cancer” compared with 59% of physicians and 46% of nonphysician HCPs (P < .001). Only 29% of patients reported that MDS was ever “curable” compared with 52% of physicians (P < .001). Physicians viewed the potential benefits of active therapy as greater than patients, but patients perceived the actual treatment experience more positively than physicians and differed from physicians in perceived reasons for stopping therapy.CONCLUSIONSPhysicians, nonphysician HCPs, and patients with MDS have disparate views of MDS characteristics and the value and limitations of treatments for MDS. Improved communication and education may increase understanding and achieve better treatment adherence and patient outcomes. Cancer 2014;120:1670–1676. © 2014 American Cancer Society.
A phase 2, single‐arm study of ramucirumab in patients with metastatic renal cell carcinoma with disease progression on or intolerance to tyrosine kinase inhibitor therapy
Authors: Garcia Jorge A. , Hudes Gary R. , Choueiri Toni K. , Stadler Walter M. , Wood Laura S. , Gurtler Jayne , Bhatia Shailender , Joshi Adarsh , Hozak Rebecca R. , Xu Yihuan , Schwartz Jonathan D. , Thompson John A. 
Published: February 2014

BACKGROUNDMultitargeted tyrosine kinase inhibitors (TKIs) have antitumor activity in metastatic renal cell carcinoma (mRCC). Resistance to these agents develops frequently, and their use is often limited by intolerance. Ramucirumab is a recombinant human monoclonal antibody directed against human vascular endothelial growth factor receptor‐2. For this study, the authors investigated the clinical efficacy and safety of ramucirumab in patients with TKI‐resistant/intolerant mRCC.METHODSIn this single‐arm phase 2 trial, patients received ramucirumab 8 mg/kg every 2 weeks until they developed disease progression or intolerable toxicity. The primary endpoint was the best objective response rate (ORR); additional endpoints included the disease control rate (DCR), progression‐free survival (PFS), the median duration of overall response, and safety.RESULTSThirty‐nine patients with RCC received ramucirumab monotherapy. Prior TKI therapy included sunitinib (59% of patients), sunitinib and sorafenib (30.8% of patients), and sorafenib (10.3% of patients). The ORR was 5.1% (95% confidence interval [CI], 0.6%‐17.3%). The 12‐week DCR was 64.1% (95% CI, 47.2%‐78.8%). The median PFS was 7.1 months (95% CI, 4.1‐9.7 months), and the median overall survival was 24.8 months (95% CI, 18.9‐32.6 months). Grade 3 or higher adverse events that occurred in ≥5% of patients included grade 3 hypertension (7.7%) and proteinuria (5.1%). There was 1 on‐study death from multiorgan failure.CONCLUSIONSAlthough the study did not meet its primary endpoint of ≥15% ORR, ramucirumab was associated with evidence of antitumor activity in patients with TKI‐resistant/intolerant mRCC. Ramucirumab was safe and well tolerated. Cancer 2014;120:1647–1655. © 2014 American Cancer Society.
Coaxial Carbon/Metal Oxide/Aligned Carbon Nanotube Arrays as High‐Performance Anodes for Lithium Ion Batteries
Authors: Lou Fengliu , Zhou Haitao , Tran Trung Dung , Melandsø Buan Marthe Emelie , Vullum‐Bruer Fride , Rønning Magnus , Walmsley John Charles , Chen De 
Published: February 2014

AbstractCoaxial carbon/metal oxide/aligned carbon nanotube (ACNT) arrays over stainless‐steel foil are reported as high‐performance binder‐free anodes for lithium ion batteries. The coaxial arrays were prepared by growth of ACNTs over stainless‐steel foil followed by coating with metal oxide and carbon. The carbon/manganese oxide/ACNT arrays can deliver an initial capacity of 738 mAh g−1 with 99.9 % capacity retention up to 100 cycles and a capacity of 374 mAh g−1 at a high current density of 6000 mA g−1. The external carbon layer was recognized as a key component for high performance, and the mechanism of performance enhancement was investigated by electrochemical impedance spectroscopy, electron microscopy, and X‐ray diffraction analysis. The layer increases rate capability by enhancing electrical conductivity and maintaining a low mass‐transfer resistance and also improves cyclic stability by avoiding aggregation of metal‐oxide particles and stabilizing the solid electrolyte interface. The resultant principle of rational electrode design was applied to an iron oxide‐based system, and similar improvements were found. These coaxial nanotube arrays present a promising strategy for the rational design of high‐performance binder‐free anodes for lithium ion batteries.
Design of a Continuous Process Setup for Precipitated Calcium Carbonate Production from Steel Converter Slag
Authors: Mattila Hannu‐Petteri , Zevenhoven Ron 
Published: February 2014

AbstractA mineral carbonation process “slag2PCC” for carbon capture, utilization, and storage is discussed. Ca is extracted from steel slag by an ammonium salt solvent and carbonated with gaseous CO2 after the separation of the residual slag. The solvent is reused after regeneration. The effects of slag properties such as the content of free lime, fractions of Ca, Si, Fe, and V, particle size, and slag storage on the Ca extraction efficiency are studied. Small particles with a high free‐lime content and minor fractions of Si and V are the most suitable. To limit the amount of impurities in the process, the slag‐to‐liquid ratio should remain below a certain value, which depends on the slag composition. Also, the design of a continuous test setup (total volume ∼75 L) is described, which enables quick process variations needed to adapt the system to the varying slag quality. Different precipitated calcium carbonate crystals (calcite and vaterite) are generated in different parts of the setup.
A pseudo‐differential current‐reuse structure for opamp‐sharing pipelined analog‐to‐digital converters
Authors: Moosazadeh Tohid , Yavari Mohammad 
Published: February 2014

SummaryIn this paper, a power efficient pseudo‐differential (PD) current‐reuse structure is presented to alleviate the memory effects of opamp‐sharing in pipelined analog‐to‐digital converters. To implement the PD current‐reuse structure, a switched‐capacitor circuit is introduced for multiplying digital‐to‐analog converter, which has a slight modification compared with the conventional switching scheme with no power penalty. In the proposed multiplying digital‐to‐analog converter circuit, the common‐mode offset amplification of the PD structures is eliminated. Moreover, a PD current‐reuse amplifier is developed from the telescopic structure with an inverter‐based gain‐boosting circuit. The effectiveness of the proposed structure is evaluated in comparison with existing current‐reuse techniques. Copyright © 2014 John Wiley & Sons, Ltd.
Activation of PI3K and R‐ras signaling promotes the extension of sensory axons on inhibitory chondroitin sulfate proteoglycans
Authors: Silver Lee , Michael James V. , Goldfinger Lawrence E. , Gallo Gianluca 
Published: February 2014

ABSTRACTChondroitin sulfate proteoglycans (CSPGs) are extracellular inhibitors of axon extension and plasticity, and cause growth cones to exhibit dystrophic behaviors. Phosphoinositide 3‐kinase (PI3K) is a lipid kinase activated by axon growth promoting signals. In this study, we used embryonic chicken dorsal root ganglion neurons to determine if CSPGs impair signaling through PI3K. We report that CSPGs inhibit PI3K signaling in axons and growth cones, as evidenced by decreased levels of phosphorylated downstream kinases (Akt and S6). Direct activation of PI3K signaling, using a cell permeable phosphopeptide (PI3Kpep), countered the effects of CSPGs on growth cones and axon extension. Both overnight and acute treatment with PI3Kpep promoted axon extension on CSPG‐coated substrates. The R‐Ras GTPase is an upstream positive regulator of PI3K signaling. Expression of constitutively active R‐Ras promoted axon extension and growth cone elaboration on CSPGs and permissive substrata. In contrast, an N‐terminus‐deleted constitutively active R‐Ras, deficient in PI3K activation, promoted axon extension but not growth cone elaboration on CSPGs and permissive substrata. These data indicate that activation of R‐Ras‐PI3K signaling may be a viable approach for manipulating axon extension on CSPGs. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 74: 918–933, 2014
Deep phylogeographic divergence of a migratory passerine in Sino‐Himalayan and Siberian forests: the Red‐flanked Bluetail (Tarsiger cyanurus) complex
Authors: Luo Site , Wu Yuchun , Chang Qing , Liu Yang , Yang Xiaojun , Zhang Zhengwang , Zhang Min , Zhang Qiang , Zou Fasheng 
Published: February 2014

AbstractEnormous mountainous forests in Sino‐Himalayans and Siberia harbor important avian biodiversity in the Northern Hemisphere. Numerous studies in last two decades have been contributed to systematics and taxonomy of passerines birds in these regions and have revealed various and complex phylogeographic patterns. A passerine species Red‐flanked Bluetail Tarsiger cyanurus provided a good system to manifest such evolutionary complexity. The subspecies T. c. cyanurus and T. c. rufilatus (or/and T. c. pallidior), divergent in morphology, acoustics, and migratory strategies are allopatric in Siberia and Sino‐Himalayan forests, respectively. The two taxa most likely deserve full species status but rigorous genetic analysis is missing. In this study, multilocus phylogeography based on mitochondrial DNA and Z‐linked DNA reveals that T. c. cyanurus and T. c. rufilatus are reciprocally monophyletic with significant statistical support and differ with a large number of diagnostic nucleotide sites resulting substantial genetic divergence. Our finding supports the proposed split of Tarsiger cyanurus s.l. that T. cyanurus and T. rufilatus should be treated as two full species. Whether “pallidior” is a subspecies or geographical form of T. rufilatus is still uncertain. Additionally, these two forest passerine species may have diverged 1.88 (3.25–1.30) Mya, which might be shaped by geographical vicariance due to grassland and desert steppe on the central Loess Plateau during the Pliocene. Taken together, this study and further suggests another independent example of North Palearctic–Sino‐Himalayan phylogeographic pattern in Palearctic birds.
Cytotoxic Titanium(IV) Complexes of Chiral Diaminobis(phenolato) Ligands: Better Combination of Activity and Stability by the Bipyrrolidine Moiety
Authors: Miller Maya , Tshuva Edit Y. 
Published: February 2014

AbstractRacemic and enantiomerically pure titanium(IV) complexes with ortho‐bromo‐para‐methyl‐substituted diaminobis(phenolato) ligands were prepared with NH‐, NMe‐, and bipyrrolidine‐based diamino bridges through ligand‐to‐metal chiral induction. The hydrolytic stability of the complexes was evaluated, and their cytotoxicity was measured using HT‐29 human colon cancer cells based on the MTT assay. All stereochemical forms of the NMe‐based complexes, although demonstrating the highest hydrolytic stability, were biologically inactive. For the NH and bipyrrolidine‐based active complexes, the pure enantiomers exhibited high cytotoxicity whereas the racemic mixtures were inactive, supporting the involvement of a polynuclear active species. The bipyrrolidine complexes appear to provide the best combination of hydrolytic stability and biological activity, presumably by minimizing steric bulk and consequently enabling biological accessibility.
Tuning Reductive and Oxidative Photoinduced Electron Transfer in Amide‐Linked Anthraquinone–Porphyrin–Ferrocene Architectures
Authors: Melomedov Jascha , Ochsmann Julian Robert , Meister Michael , Laquai Frédéric , Heinze Katja 
Published: February 2014

AbstractPorphyrin amino acids 3a–3h with meso substituents Ar of tunable electron‐donating power (Ar = 4‐C6H4OnBu, 4‐C6H4OMe, 4‐C6H4Me, Mes, C6H5, 4‐C6H4F, 4‐C6H4CF3, C6F5) have been linked at the N terminus to anthraquinone Q as electron acceptor through amide bonds to give Q‐PAr dyads 4a–4h. These were conjugated to ferrocene Fc at the C terminus as electron donor to give the acceptor‐chromophore‐donor Q‐PAr‐Fc triads 6a–6h. To further modify the energies of the electronically excited and charge‐separated states, the triads 6a–6h were metallated with zinc(II) to give the corresponding Q‐(Zn)PAr‐Fc triads Zn‐6a–Zn‐6h. The Q‐PAr1 dyad (Ar1 = C6H5) was further extended with a second porphyrin PAr2 (Ar2 = 4‐C6H4Me) as well as appended to a ferrocene to give the tetrad Q‐PAr1‐PAr2‐Fc 9. Almost all the conjugates show strongly reduced fluorescence quantum yields and excited‐state lifetimes, which has been interpreted as photoinduced electron transfer (PET) either from the excited porphyrin to the quinone (oxidative PET) or from the ferrocene to the excited porphyrin (reductive PET). Electrochemical data, absorption spectroscopy, steady‐state emission, time‐resolved fluorescence, transient absorption pump‐probe spectroscopy as well as DFT calculations have been used to elaborate the preferred PET pathway (reductive vs. oxidative PET) in these architectures with systematically varied electron‐donating substituents at the central chromophore.
Synthesis of 1,2,3‐Triazole‐4‐carboxamide‐Containing Foldamers for Sulfate Recognition
Authors: Cao Li , Jiang Runsheng , Zhu Yulan , Wang Xinlong , Li Yongjun , Li Yuliang 
Published: February 2014

AbstractA series of triazolecarboxamide‐containing foldamers were synthesized from simple starting materials by means of repeated [3+2] cycloadditions) and acid–amine coupling reactions. Foldamer–anion binding behavior and affinities were determined by 1H NMR titration in [D2]dichloromethane. The selective recognition of sulfate by these motifs was studied by one‐ and two‐dimensional (1H, 1H‐1H COSY and NOESY) NMR spectroscopy as well as UV/Visible and fluorescence titrations. The structures of the triazolecarboxamide‐containing foldamers can be optimized for highly selective recognition of sulfate anions by changing the numbers of triazolecarboxamide units and by the introduction of electron‐withdrawing substituents on the terminal benzene ring. These findings indicate the importance of the structural compatibility between the receptor and anions for the highly selective anion binding as well as the electronic effect on tuning the anion‐binding affinities of receptors.
On the Use of Amperometry for Real Time Assessment of Drug‐Release Profile from Therapeutic Nanoparticles
Authors: Ensafi Ali A. , Heydari‐Bafrooei Esmaeil , Rezaei Behzad 
Published: February 2014

AbstractA simple electrochemical method was used to directly assess the drug‐release profile. The method is based on the multiple pulse amperometric measurement of the oxidation and reduction of doxorubicin released from liposome at a MWCNTs‐modified glassy carbon electrode (MWCNT‐GCE). The released doxorubicin was detected at +0.60 and −0.60 V by two different oxidation and reduction processes, respectively. The third potential pulse (−1.00 V) was applied for the regeneration of MWCNT‐GCE. The main advantage of this method is that there is no need for any operation for the quantitative analysis during the release of the drug from nanoparticles.