bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards increased relevance: context-adapted models of the learning organization
Authors: Örtenblad Anders 
Published: June 2015

Purpose– The purposes of this paper are to take a closer look at the relevance of the idea of the learning organization for organizations in different generalized organizational contexts; to open up for the existence of multiple, context-adapted models of the learning organization; and to suggest a number of such models.Design/methodology/approach– The suggested context-adapted models are deduced from works arguing that not all aspects of the idea of the learning organization should be adopted by organizations in some certain generalized organizational contexts.Findings– The idea of the learning organization needs to be reformulated, to some extent, to become fully relevant for public organizations, safety organizations, human service organizations and knowledge-intensive organizations.Research limitations/implications– To achieve a more inclusive contingency model than presented in this article, there is a need for further research examining the (full) relevance of the original learning organizational model for organizations in various certain generalized organizational contexts.Practical implications– Organizational actors could use one of the suggested context-adapted models fitting their particular organizational context as a starting point when considering adopting the learning organization.Social implications– Several adaptations suggested originate in social concerns.Originality/value– In contrast to most previous works on the learning organization, this paper adds to the existing literature by proposing several context-adapted models of the learning organization.
Relationships between mixed features and borderline personality disorder in 2811 patients with major depressive episode
Authors: Perugi G. , Angst J. , Azorin J.‐M. , Bowden C. L. , Caciagli A. , Mosolov S. , Vieta E. , Young A. H. ,   the BRIDGE‐II‐Mix Study Group
Published: June 2015

ObjectiveThe study focused on the relationship between mixed depression and borderline personality disorder (BPD).MethodThe sample comprised 2811 patients with a major depressive episode (MDE). Clinical characteristics were compared in patients with (BPD+) and without (BPD−) comorbid BPD and in BPD+ with (MXS+) and without (MXS−) mixed features according to DSM‐5 criteria.ResultsA total of 187 patients (6.7%) met the criteria for BPD. A DSM‐IV‐TR diagnosis of bipolar disorder (BD) was significantly more frequent in patients with BPD+ than in patients with BPD. Patients with BPD+ were significantly younger and reported lower age at onset than BPD−. Patients with BPD+ also showed more hypomania/mania in first‐degree relatives in comparison with patients with BPD−, as well as more psychiatric comorbidity, mixed features, atypical features, suicide attempts, prior mood episodes and antidepressant‐induced hypo/manic switches. Mixed features according to DSM‐5 criteria were observed in 52 (27.8%) BPD+. In comparison with MXS−, MXS+ were significantly younger at age of onset and at prior mood episode and had experienced more mood episodes and hypo/manic switches with antidepressant treatments.ConclusionMajor depressive episode patients with comorbid BPD reported a high prevalence of mixed features and BD. The presence of DSM‐5 mixed features in MDE patients with BPD may be associated with complex course and reduced treatment response.
Documenting Arts Practitioners’ Practice in Prisons: ‘What Do You Do in There?’
Authors: ANDERSON KIRSTIN 
Published: June 2015

AbstractThis article explores arts practitioners’ methods in leading workshops with prisoners as part of the Inspiring Change pilot, a co‐ordinated pilot programme of arts interventions that took place in five Scottish prisons throughout 2010. Session review forms, which were completed by arts practitioners after each session, were designed to find out what happened in sessions, what worked well with prisoners in these sessions and what did not. Very little has been written on the arts practitioners’ methods and, in particular, the data gathered from session review forms. This article discusses the data gathered and three themes that came out of the arts practitioners’ responses including ‘Response to planned activity’, ‘Response to working in a prison environment’, and ‘Development of skills for participants’. The article concludes that documenting arts practitioners’ practice can contribute to the understanding of the connection and role of the arts in desistance studies.
Hybrid approach for the two‐dimensional bin packing problem with two‐staged patterns
Authors: Cui Yaodong , Yao Yi , Cui Yi‐Ping 
Published: June 2015

AbstractThis paper presents a two‐phase heuristic approach for the two‐dimensional bin packing problem with two‐staged patterns and nonoriented items. A solution is generated in each phase and the better one is selected. Residual problems are solved by column generation in the first phase, where a partial admitting procedure is used to admit some of the patterns into the phase‐1 solution. The second solution is obtained from solving an integer linear programming problem over the set of all patterns generated in the first phase, where a time limit is used and subsequently the solution may not be optimal over the pattern set. The computational results indicate that the approach yields the best solution quality among the heuristics that use two‐staged or more complex patterns.
Rice potassium transporter OsHAK1 is essential for maintaining potassium‐mediated growth and functions in salt tolerance over low and high potassium concentration ranges
Authors: Chen Guang , Hu Qingdi , Luo Le , Yang Tianyuan , Zhang Song , Hu Yibing , Yu Ling , Xu Guohua 
Published: June 2015

AbstractPotassium (K) absorption and translocation in plants rely upon multiple K transporters for adapting varied K supply and saline conditions. Here, we report the expression patterns and physiological roles of OsHAK1, a member belonging to the KT/KUP/HAK gene family in rice (Oryza sativa L.). The expression of OsHAK1 is up‐regulated by K deficiency or salt stress in various tissues, particularly in the root and shoot apical meristem, the epidermises and steles of root, and vascular bundles of shoot. Both oshak1 knockout mutants in comparison to their respective Dongjin or Manan wild types showed a dramatic reduction in K concentration and stunted root and shoot growth. Knockout of OsHAK1 reduced the K absorption rate of unit root surface area by ∼50–55 and ∼30%, and total K uptake by ∼80 and ∼65% at 0.05–0.1 and 1 mm K supply level, respectively. The root net high‐affinity K uptake of oshak1 mutants was sensitive to salt stress but not to ammonium supply. Overexpression of OsHAK1 in rice increased K uptake and K/Na ratio. The positive relationship between K concentration and shoot biomass in the mutants suggests that OsHAK1 plays an essential role in K‐mediated rice growth and salt tolerance over low and high K concentration ranges.
Clonal populations of Clavibacter michiganensis subsp. michiganensis are responsible for the outbreaks of bacterial canker in greenhouse tomatoes in Italy
Authors: Ialacci G. M. , Bella P. , Licciardello G. , Strano C. P. , Eichenlaub R. , Gartemann K.‐H. , La Rosa R. , Catara V. 
Published: June 2015

Clavibacter michiganensis subsp. michiganensis (Cmm) strains, collected in greenhouses from 17 farms during tomato bacterial canker outbreaks occurring between 2005 and 2008 in Sicily, were analysed by a multiphasic approach. Population studies were conducted to investigate the possible sources of inocula. Cmm strains were characterized by PCR assays targeting virulence genes, fingerprinting techniques, metabolic profiles and virulence. These strains were comparatively analysed with Cmm strains isolated in other parts of Italy over a period of 15 years. Chromosomal genes encoding virulence determinants tomA, ppaA, chpC, and the plasmid‐encoded genes pat‐1 and celA were detected by PCR in all tested strains, except for four Sicilian Cmm strains where the pat‐1 gene was not amplified. Using BOX‐PCR, Cmm strains were differentiated into 13 haplotypes and clonal populations were identified. Cmm strains isolated from different farms in 2008 showed the same BOX‐PCR haplotype. A distinct BOX‐PCR haplotype was obtained from atypical Cmm strains lacking pat‐1 and isolated in 2006/7 from three farms. Cmm strains with two different haplotypes were detected in one farm, whereas the other farms contained strains with only a single haplotype. A new fAFLP protocol based on the amplification of ApaI/MseI fragments was developed and was able to differentiate C. michiganensis subspecies. Different populations were delineated for the multiple outbreaks occurring in Sicily, whereas similar populations were recorded in other Italian regions over a period of 12 years. The results are consistent with previous studies that demonstrate that Cmm outbreaks are associated with propagation material.
Association of Inducible T Cell Costimulator Polymorphisms with Susceptibility and Outcome of Hepatitis B Virus Infection in a Chinese Han Population
Authors: Hu J. , Li Q.‐L. , Hou S.‐H. , Peng H. , Guo J.‐J. 
Published: June 2015

AbstractInducible T cell costimulator (ICOS) functions to regulate cell–cell signalling, immune responses and cell proliferation. ICOS single nucleotide polymorphism (SNP) may affect protein expression and functions. This study investigated the association of ICOS SNPs with hepatitis B virus (HBV) infection and outcome in a Chinese population. A total of 1290 Chinese Han individuals were enrolled, including 63 asymptomatic HBV carriers, 220 chronic hepatitis B patients (CHB), 249 HBV‐related liver cirrhosis patients (LC), 108 patients with HBV‐related hepatocellular carcinoma (HCC), 338 patients with natural HBV clearance and 312 healthy subjects (as controls). DNA samples from these subjects were genotyped for four ICOS SNPs (rs11883722, rs10932029, rs1559931 and rs4675379) using TaqMan SNP Genotyping Assay and analysed. The data showed that genotype and allele frequencies of ICOS SNPs in cases and controls followed the Hardy–Weinberg distribution. The CC genotype of rs4675379 was higher in patients with HBV infection (including AC, CHB, LC and HCC) than in patients with HBV clearance (P = 0.006). Furthermore, the genotype ‘GA’ and the minor allele ‘A’ of rs1559931 were associated with a decreased HCC susceptibility (P < 0.001). Haplotype analysis data showed that ‘GC’ haplotype in block 2 (rs1559931 and rs4675379) had a lower frequency in patients than in HBV‐cleared subjects (P = 0.034), although its overall frequency was only 1.6%. Our study found that ICOS rs1559931 SNP was associated with decreased HBV‐related HCC risk in the studied Chinese Han population, except for patients with natural clearance of HBV.
Metagenome Sequencing Reveals
Rhodococcus
Dominance in Farpuk Cave, Mizoram, India, an Eastern Himalayan Biodiversity Hot Spot Region
Authors: De Mandal Surajit , Sanga Zothan , Senthil Kumar Nachimuthu 
Published: June 2015

ABSTRACT

The present study employed 16S rRNA amplicon sequencing to survey the prokaryotic microbiota on Farpuk Cave, revealing a diverse bacterial community with 4,021 operational taxonomical units (OTUs), mainly dominated by the genus
Rhodococcus
. Moreover, 18.17% of the OTUs were unclassified at the phylum level, suggesting the existence of novel bacterial species.
Complete Genome Sequence of the Bacterium Aalborg_AAW-1, Representing a Novel Family within the Candidate Phylum SR1
Authors: Dueholm Morten Simonsen , Albertsen Mads , Stokholm-Bjerregaard Mikkel , McIlroy Simon J. , Karst Søren M. , Nielsen Per Halkjær 
Published: June 2015

ABSTRACT
Here, we present the complete genome sequence of the candidate phylum SR1 bacterium Aalborg_AAW-1. Its 16S rRNA gene is only 85.5% similar to that of the closest relative, RAAC1_SR1, and the genome of Aalborg_AAW-1 consequently represents the first of a novel family within the candidate phylum SR1.
Complete Genome Sequence of a Bovine Viral Diarrhea Virus Subgenotype 1e Strain Isolated in Switzerland
Authors: Stalder Hanspeter , Schweizer Matthias , Bachofen Claudia 
Published: June 2015

ABSTRACT
We sequenced the complete genome of the bovine viral diarrhea virus (BVDV) strain Carlito. It belongs to the subgenotype 1e that is described in Europe only and represents the second most prevalent subgenotype in Switzerland. This is the first report of a full-length sequence of BVDV-1e.
Draft Genome Sequence of Microbacterium profundi Shh49
T
, an Actinobacterium Isolated from Deep-Sea Sediment of a Polymetallic Nodule Environment
Authors: Wu Yue-Hong , Zhou Peng , Cheng Hong , Wang Chun-Sheng , Wu Min , Xu Xue-Wei 
Published: June 2015

ABSTRACT

Microbacterium profundi
strain Shh49
T
was isolated from deep-sea sediment from a polymetallic nodule area located in the East Pacific Ocean. Strain Shh49
T
contains genes related to the reduction/oxidation of metals. It has potential application in the bioremediation of heavy metal-contaminated environments.
Health literacy and 30-day hospital readmission after acute myocardial infarction
Authors: Bailey Stacy Cooper , Fang Gang , Annis Izabela E , O'Conor Rachel , Paasche-Orlow Michael K , Wolf Michael S 
Published: June 2015

ObjectiveTo assess the validity of a predictive model of health literacy, and to examine the relationship between derived health literacy estimates and 30-day hospital readmissions for acute myocardial infarction (AMI).DesignRetrospective cohort study.Setting and participantsA National Institute of Aging (NIA) study cohort of 696 adult, English-speaking primary care patients, aged 55–74 years, was used to assess the validity of derived health literacy estimates. Claims from 7733 Medicare beneficiaries hospitalised for AMI in 2008 in North Carolina and Illinois were used to investigate the association between health literacy estimates and 30-day hospital readmissions.MeasuresThe NIA cohort was administered 3 common health literacy assessments (Newest Vital Sign, Test of Functional Health Literacy in Adults, and Rapid Estimate of Adult Literacy in Medicine). Health literacy estimates at the census block group level were derived via a predictive model. 30-day readmissions were measured from Medicare claims data using a validated algorithm.ResultsFair agreement was found between derived estimates and in-person literacy assessments (Pearson Correlation coefficients: 0.38–0.51; κ scores: 0.38–0.40). Medicare enrollees with above basic literacy according to derived health literacy estimates had an 18% lower risk of a 30-day readmission (RR=0.82, 95% CI 0.73 to 0.92) and 21% lower incidence rate of 30-day readmission (IRR=0.79, 95% CI 0.68 to 0.87) than patients with basic or below basic literacy. After adjusting for demographic and clinical characteristics, the risk of 30-day readmission was 12% lower (p=0.03), and the incidence rate 16% lower (p<0.01) for patients with above basic literacy.ConclusionsHealth literacy, as measured by a predictive model, was found to be a significant, independent predictor of 30-day readmissions. As a modifiable risk factor with evidence-based solutions, health literacy should be considered in readmission reduction efforts.
Unsafe sexual behaviour in domestic and foreign migrant male workers in multinational workplaces in Jordan: occupational-based and behavioural assessment survey
Authors: Al Rifai Rami , Nakamura Keiko , Seino Kaoruko , Kizuki Masashi , Morita Ayako 
Published: June 2015

ObjectivesTo examine the prevalence of unsafe sexual behaviour, sexually transmitted infection (STI)-related knowledge, health and work-related conditions, and correlates of practising unsafe sex among domestic and foreign male workers in multinational workplaces in Jordan.DesignCross-sectional behavioural assessment survey.SettingMultinational workplaces in Jordan.Participants230 Jordanian and 480 foreign male workers aged ≥18 years who had worked in a Qualified Industrial Zone (QIZ) for 12 months or more.OutcomesThe primary outcome was the prevalence of practising unsafe sex. ‘Unsafe sex’ was defined as sex with a non-regular sexual partner with inconsistent condom usage.ResultsOverall, 74.3% of workers reported lifetime sexual experience. The proportion of lifetime unsafe sex was similar among domestic (31.8%) and foreign (35.6%) workers. Of those, 59.2% of domestic and 68.1% of foreign workers started practising unsafe sex after joining the QIZ. Rates of lifetime unsafe sex were significantly higher among those who had their sexual debut after joining the QIZ in domestic (aOR, 2.2, 95% CI 1.1 to 4.4) and foreign workers (aOR, 2.4, 95% CI 1.4 to 4.1). Among the domestic workers, being 18–24 years old (aOR, 4.9), unmarried (aOR, 4.8), working in the QIZ for 5–8 years (aOR, 5.0), sometimes/frequently shopped with foreign workers (aOR, 2.1) or were current/ex-alcohol drinkers (aORs, 3.4) were independently significantly associated with higher odds of practising unsafe sex.ConclusionsA significant proportion of domestic and foreign male workers had been practising unsafe sex. The findings indicated that not only foreigners but also domestic male workers associating with foreign workers are at high risk of unsafe sex. Tailored interventions to promote safer sex in multinational workplaces in Jordan are needed.
Gene–gene interactions between TGF-β/Smad3 signalling pathway polymorphisms affect susceptibility to knee osteoarthritis
Authors: Su Sui-Lung , Yang Hsin-Yi , Lee Herng-Sheng , Huang Guo-Shu , Lee Chian-Her , Liu Wan-Shan , Wang Chih-Chien , Peng Yi-Jen , Lai Ching-Huang , Chen Ching-Yang , Lin Chin , Pan Yu-Ting , Salter Donald M , Chen Hsiang-Cheng 
Published: June 2015

ObjectiveTransforming growth factor/Smad family member 3 (TGF)-β/Smad3 signalling is essential for maintaining articular cartilage. A relationship between the genetic variants of TGF-β itself, TGF-β signalling and binding molecules, and osteoarthritis (OA) has been reported. Although variants of candidate genes have become prime targets for genetic analysis, their detailed interplay has not been documented. Our goal was to establish whether single nucleotide polymorphisms (SNPs) of TGF-β1, TGF-βRI, Smad3 and tissue inhibitor of metalloproteinases 3 (TIMP3), and their interactions, are associated with knee OA.DesignWe performed a case–control association study and genotyped 518 knee patients with OA and 468 healthy controls. All participants were genotyped for TGF-β1 (rs1800469C/T), TGF-βRI (rs1590A/G), Smad3 (rs12901499A/G and rs6494629T/C), and TIMP3 (rs715572G/A and rs1962223G/C) polymorphisms by polymerase chain reaction–restriction fragment length polymorphism analysis. Multifactor dimensionality reduction (MDR) was used to identify gene–gene interactions.ResultsSignificant associations were observed for TIMP3 rs715572G/A polymorphisms in knee patients with OA and healthy individuals. The GA heterozygote in TIMP3 (rs715572G/A) was significantly associated with OA (p=0.007). Patient stratification using the Kellgren–Lawrence grading scale showed significant differences in TIMP3 rs715572G/A genotypes between grade 4 knee OA and controls. By MDR analysis, a two-locus model (Smad3 rs6494629T/C and TIMP3 rs715572G/A) of gene–gene interaction was the best for predicting knee OA risk, and its maximum testing accuracy was 57.55% and maximum cross-validation consistency was 10/10.ConclusionsTIMP3 rs715572G/A is a candidate protective gene for severe knee OA. Gene–gene interactions between Smad3 rs6494629T/C and TIMP3 rs715572G/A polymorphisms may play more important protective roles in knee OA.
Glaucoma awareness and access to healthcare: perceptions among glaucoma patients in Tanzania
Authors: Gilmour-White Jeremy A , Shah Peter , Cross Vinette , Makupa William , Philippin Heiko 
Published: June 2015

ABSTRACT

Objective
To investigate the barriers to access to eye health services for patients with glaucoma in Tanzania with the aim of identifying key areas for improvement and further research.

Design
Qualitative investigation using face-to-face semi-structured interviews with patients recruited from the Kilimanjaro Christian Medical Centre (KCMC) outpatient eye clinic. This project is part of the international strategy of the Research into Glaucoma and Ethnicity (ReGAE) programme.

Methods
Interviews were conducted with the help of a translator; all data were transcribed in Swahili and then translated into English. Manual coding and qualitative analysis was used to identify major themes and relevant concepts. Data were collected during May and June 2013.

Main outcome measures
Qualitative data on glaucoma awareness and access to healthcare.

Results
12 patients (7 men, 5 women) of mean age 67.5 years (range 53–86 years) were interviewed. All participants had a previous diagnosis of glaucoma and no other eye conditions. The understanding of glaucoma was limited and the capacity for healthcare providers to improve glaucoma knowledge seemed underused. Participants had particular difficulty in understanding the aetiology and chronicity of the disease. Socioeconomic factors also posed significant barriers to service usage.

Conclusions
Among many barriers to access to health services for patients with glaucoma, knowledge of the condition was identified as a key issue. Enhancing the understanding of glaucoma may improve access by triggering earlier presentation, informing those at risk and improving adherence to treatment. This is an area for further research with potential for improving service provision.
Oncogenic Transformation Can Orchestrate Immune Evasion and Inflammation in Human Mesenchymal Stem Cells Independently of Extrinsic Immune-Selective Pressure
Authors: Miranda Alex , Funes Juan M. , Sánchez Nilda , Limia Celia M. , Mesa Mónica , Quezada Sergio A. , Pérez Rolando , de León Joel 
Published: June 2015

AbstractImmune escape is a hallmark of cancer, but whether it relies upon extrinsic immune-selective pressure or is inherently orchestrated by oncogenic pathways is unresolved. To address this question, we took advantage of an in vitro model of sequentially transformed human mesenchymal stem cells (hMSC). Neoplastic transformation in this model increased the natural immune-evasive properties of hMSC, both by reducing their immunogenicity and by increasing their capacity to inhibit mitogen-driven T-cell proliferation. We also found that IFNγ signaling was globally affected in transformed hMSC. As a consequence, the natural inhibitory effect of hMSC on T-cell proliferation switched from an inducible mechanism depending on IFNγ signaling and mediated by indoleamine 2,3-dioxygenase to a constitutive mechanism that relied upon IL1β involving both secreted and membrane-expressed molecules. After transformation, increased IL1β expression both sustained the immunosuppressive properties of hMSC and increased their tumorigenicity. Thus, in this model system, IL1β acted as intrinsic inflammatory mediator that exerted an autocrine influence on tumor growth by coordinately linking immune escape and tumorigenicity. Collectively, our findings show how oncogenes directly orchestrate inflammation and immune escape to drive the multistep process of cancer progression, independently of any need for immunoediting in the tumor microenvironment. Cancer Res; 75(15); 3032–42. ©2015 AACR.