bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advancing transculturally informed, humanistic therapeutic practice for refugees and asylum seekers presenting with embodied trauma
Authors: O'Brien Charlotte , Charura Divine 
Published: August 2024

AbstractIntroductionA record of 122.6 million people have sought refuge and asylum across the globe in 2024, exacerbated by emergencies in Ukraine, Sudan, Afghanistan and by the Israel–Hamas war. This number is set to rise to over 130 million people in refugee situations in 59 countries this year alone. With refugees suffering from higher rates of mental health difficulties than the general population, there is an urgent need to provide an expedient, socially just, transculturally informed pathway into humanistic psychological care services for these individuals. The objectives of this study were to explore how therapeutic practitioners are working effectively with displaced individuals presenting with embodied trauma, their experiences of transcultural approaches to therapeutic work and the impact of working alongside psychopharmacological medications in this commonly overprescribed client group.MethodA qualitative semi‐structured interview was operationalised with 12 therapeutic practitioners who have worked with displaced individuals, utilising reflexive thematic analysis of the data.ResultsFindings highlight a critical need for an updated transculturally informed, humanistic, person‐centred pathway of care for each displaced individual.DiscussionThis study offers facilitators and challenges to using a humanistic, transculturally updated assessment, formulation, treatment plan, and routine outcome measures for embodied trauma. It also considers the importance of working with a client's cultural context of origin, language, universally understood emotions, cultural strengths, preferences for therapy and use of a psychopharmacological review within a holistic constellation of care.
Research Progress on Plant‐Derived Cardenolides (2010–2023)
Authors: He Yi‐Lin , Yang Hong‐Ying , Zhang Lei , Gong Zheng , Li Guo‐Li , Gao Kun 
Published: August 2024

AbstractCardenolides are a class of steroidal glycoside compounds that are mainly distributed in plants, have significant physiological activity in the heart, and have been used clinically for over 200 years. To provide a reference for further research and development of these compounds, the phytochemical and biological properties of natural cardenolides (295 compounds in total) isolated between 2010 and 2023 from 17 families and hundreds of species belonging to 70–80 genera were reviewed. In vitro and in vivo studies have indicated that antitumor, antibacterial, and antiviral activities are the most commonly reported pharmacological properties of cardenolides. Antitumor activities have been thoroughly studied to understand their structure‐activity relationships, revealing numerous potential anticancer molecules that lay the theoretical foundation for further development of traditional Chinese medicinal herbs and the creation of new drugs.
Significance of diabetes mellitus status in patients undergoing percutaneous left main coronary artery intervention
Authors: Roumeliotis Anastasios , Siasos Gerasimos , Dangas George , Power David , Sartori Samantha , Vavouranakis Manolis , Tsioufis Konstantinos , Leone Pier Pasquale , Vogel Birgit , Cao Davide , Oliva Angelo , Oikonomou Evangelos , Smith Kenneth F. , Sweeny Joseph , Krishnan Prakash , Kini Annapoorna , Sharma Samin , Mehran Roxana 
Published: August 2024

AbstractBackgroundDiabetes mellitus (DM) is a modifiable risk factor for patients with coronary artery disease (CAD). Treatment with insulin correlates with advanced disease and has been associated with excess cardiovascular risk, but evidence on outcomes of patients with insulin‐treated DM (ITDM) undergoing left main percutaneous coronary intervention (LMPCI) remains scarce.AimsThe aim of the presented study is to evluate the risk attributable to DM and ITDM in patients undergoing LMPCI.MethodsWe included 869 patients undergoing PCI for unprotected LMCAD. The cohort was divided into three subgroups based on diabetic status: No DM, ITDM, and Non‐ITDM. The primary endpoint was major adverse cardiac and cerebrovascular events (MACCE), defined as a composite of death, spontaneous myocardial infarction (MI), or stroke at 1 year. Results were adjusted for clinically relevant baseline characteristics.ResultsAmongst participants, 58.7% had no DM, 25.9% non‐ITDM, and 15.4% ITDM. Diabetics were younger and more likely to be female. They also exhibited higher body mass index as well as prevalence of comorbidities, including hypertension, anemia, and chronic kidney disease. The number of bifurcation lesions and stents used was similar between groups. At 1 year, when compared to no DM, ITDM (25.4% vs. 10.0%, p < 0.01) but not non‐ITDM (10.8% vs. 10.0%, p = 0.94) demonstrated higher MACCE. This finding was driven by increased risk of MI. Mortality was 8.4%, 7.8%, and 17.2% for no DM, Non‐ITDM, and ITDM, respectively. Results remained unchanged after adjustment.ConclusionsIn a rather contemporary patient population undergoing PCI for LMCAD, ITDM but not non‐ITDM was associated with higher risk of 1‐year MACCE, primarily driven by MI.
Ingestion of several rubber gloves: A case report on Pica syndrome
Authors: Winterland Sarah , Schmidt Jeremy , Nordhoff Dennis , Barthlen Winfried , Hamelmann Eckard , Gaus Sebastian 
Published: August 2024

Key Clinical MessageAfter ingestion rubber gloves harden and can produce dangerous complications. Therefore the choice of treatment is of utmost importance. Aside from a surgical approach, endoscopy should also be considered as a treatment option on a case‐to‐case basis or if not applicable as a useful diagnostic tool.
Research Progress on the Pitch‐Based Anode Materials for Sodium‐Ion Batteries
Authors: Zhang Yukun , Lin Xiongchao , Xi Wenshuai , Gao Hongfeng , Wang Caihong , Liu Di , Wang Yonggang 
Published: August 2024

AbstractThis paper conducts a comprehensive review of the modification approaches for sodium‐ion anode materials fabricated using pitch‐based carbon. The current status of pitch‐based carbon preparation of anode materials for sodium‐ion batteries (SIBs) by heteroatom doping, morphology construction, and composite materials is introduced. The effects of different modification methods of pitch‐based carbon on their sodium storage performance were analyzed and compared. A variety of pitch‐based carbon modification mechanisms are also elucidated. From a microscopic perspective, the characteristics of pitch‐based carbon applied to the anode of SIBs are expounded, which has a certain guiding significance for the rational design of the microstructure of pitch‐based sodium‐ion battery anode materials. The commercial application of pitch‐based sodium‐ion battery anode materials relies on a simple and effective modification process.
Crystallography Reveals Metal‐Triggered Restructuring of β‐Hairpins
Authors: Thuc Dang Viet , Engineer Aryan , McElheny Dan , Drena Alexander , Telser Joshua , Tomczak Kyle , Nguyen Andy I. 
Published: August 2024

AbstractMetal binding to β‐sheets occurs in many metalloproteins and is also implicated in the pathology of Alzheimer's disease. De novo designed metallo‐β‐sheets have been pursued as models and mimics of these proteins. However, no crystal structures of canonical β‐sheet metallopeptides have yet been obtained, in stark contrast to many examples for ɑ‐helical metallopeptides, leading to a poor understanding for their chemistry. To address this, we have engineered tryptophan zippers, stable 12‐residue β‐sheet peptides, to bind Cu(II) ions and obtained crystal structures through single crystal X‐ray diffraction (SC‐XRD). We find that metal binding triggers several unexpected supramolecular assemblies that demonstrate the range of higher‐order structures available to metallo‐β‐sheets. Overall, these findings underscore the importance of crystallography in elucidating the rich structural landscape of metallo‐β‐sheet peptides.
Heterometallic‐Organic Cages with Customized Cavities: Constructed by Bottom‐Up Step‐Wise Coordination‐Driven Self‐Assembly
Authors: Li Kaixiu , Liu Mingliang , Li Zhengguang , Chen Mingzhao , Wang Jun , Yuan Jie , Jiang Zhilong , Li Yiming , Wang Pingshan , Liu Die 
Published: August 2024

AbstractAccurately synthesizing coordination‐driven metal‐organic cages with customized shape and cavity remains a great challenge for chemists. In this work, a bottom‐up step‐wise coordination‐driven self‐assembly approach was put forward. Employing this strategy, three terpyridyl heterometallic‐organic truncated tetrahedral cages with different sizes and cavity were precisely synthesized. Firstly, the coordination of tripodal organic ligands with Ru2+ afforded dendritic metal‐organic ligands L1‐L3. Then the Ru building blocks complexed with Fe2+ and shrunk to form the desired heterometallic‐organic cages (C1‐C3). These discrete heterometallic‐organic supramolecular cages were fully characterized and displayed the large and open cavities varied from 7205 Å3 to 9384 Å3. Notably, these cages could not be directly constructed by single‐step assembly process using initial organic ligands or dimeric metal‐organic ligands, indicative of the irreplaceability of a bottom‐up step‐wise assembly strategy for size‐customized architectures. This work paves a new way for precisely constructing metal‐organic cages with well‐defined cavities.
Gewinnung von Fettsäuremethylestern aus industriellem Kaffeesatz mittels eines In‐situ‐Prozesses
Authors: Grän‐Heedfeld Jürgen , Kraft Axel , Fastabend Anna , Kahl Fabian 
Published: August 2024

ZusammenfassungIn Kaffeesatz enthaltenes Kaffeeöl weist einen nennenswerten Anteil an ungesättigten Fettsäuren auf. In einem vom Bundesministerium für Bildung und Forschung (BMBF) geförderten Projekt wurde Kaffeesatz aus der industriellen Herstellung von Instant‐Kaffee für die Nutzung in der stoffverarbeitenden Industrie untersucht, wobei die Isolierung, Funktionalisierung und Nutzung der ungesättigten Fettsäuren einen Schwerpunkt darstellte. Durch einen In‐situ‐Prozess der Ver‐ und Umesterung wurden die im Kaffeesatz enthaltenen Fettsäuren in Form von Fettsäuremethylestern zugänglich gemacht.
The Investigation of Hsp90C‐Terminal Inhibitors Containing Amide Bioisosteres
Authors: Amatya Eva , Subramanian Chitra , Long Reagan , McNamara Kelli , Cohen Mark S. , Blagg Brian S. J. 
Published: August 2024

AbstractHeat Shock Protein 90 (Hsp90) is responsible for the proper folding and maturation of ~400 client protein substrates, many of which are directly associated with the ten hallmarks of cancer. Hsp90 is a great target for cancer therapy including melanoma, since Hsp90 inhibition can disrupt multiple oncogenic pathways simultaneously. In this study, we report the synthesis and anti‐proliferative activity manifested by a series of Hsp90 C‐terminal inhibitors against mutant BRAF and wild‐type BRAF melanoma cells. Furthermore, we explored structure‐activity relationships (SAR) for the amide moiety of 6 (B1), a novel Hsp90C‐terminal inhibitor via introduction of amide bioisosteres. Compound 6 displayed an IC50 of 1.01 μM, 0.782 μM, 0.607 μM and 1.413 μM against SKMel173, SKMel103, SKMel19 and A375 cells, respectively.
Organic‐Inorganic Hybrid Material for Photocatalytic H₂ Evolution: Electron Shuttling between Photoresponsive Nanocomposite and Co(II) Redox Mediator
Authors: Augustin Ashil , Santhosh Yesupatham Manova , Shenoy Sulakshana , Dhileepan M. D. , Neppolian Bernaurdshaw , Sekar Karthikeyan 
Published: August 2024

AbstractIn this report, a conductive polymer encapsulated metal oxide photocatalyst is developed through a straightforward insitu synthesis method wherein, polythiophene is incorporated with TiO2 nanoparticles which imparts enhanced visible‐light absorption to the samples and significantly improves the efficiency of charge transfer resulting due to the vacancy defects and high conductivity, ultimately leading to exceptional performance in H2 production. Significantly, the rate of H2 production was enhanced even further through the deposition of simple redox mediator. The introduction of Co2+ facilitates the transfer of photogenerated holes from the valence band by its conversion from +2 to +3 oxidation state which further enables the oxidation mechanism. The recombination rate of excitons has been significantly reduced due to the efficient transfer of photogenerated holes and the rate of photocatalytic H2 production is improved. Interestingly, the valence states and local atomic structure of the Ti species in the synthesized sample were ascertained through the utilization of Ti K‐edge XANES and EXAFS analysis, which validated the energy position.
Channel equalization through pre‐denoising using a hybrid multiscale decomposition in an impulsive noise environment
Authors: Wilson Annet Mary , Panigrahi Trilochan , Mishra Bishnu Prasad , Sabat Samrat L 
Published: August 2024

SummaryIn wireless communication, impulsive noise often degrades channel quality, which poses challenges for equalizers. Although robust equalization methods offer some effectiveness, the occurrence of impulsive noise after training significantly impacts the symbol error rate (SER). To mitigate this issue, we propose a method that involves denoising the received signal using robust wavelet decomposition before equalization. This approach combines the discrete wavelet transform with median and morphological filters to reduce impulsive noise. A pre‐impulsive noise detection mechanism triggers denoising only when impulsive noise is detected. We evaluate the SER performance of the proposed technique using simulations of a 16‐QAM orthogonal frequency division multiplexing (OFDM) system with kernel interpolation‐based frequency domain equalization (FDE) in a Rayleigh fading channel with impulsive noise. Results show that our approach achieves SER levels comparable to conventional methods in Gaussian noise scenarios, demonstrating its effectiveness in challenging wireless communication environments. The simulation results demonstrate that the proposed technique in non‐Gaussian noise gives the SER on par with the FDE in a Gaussian noise environment.
Mobility‐compatible cache controlled cluster networking protocol
Authors: Sunhare Priyank , Chattopadhyay Manju K. 
Published: August 2024

SummaryThe cluster networking protocols are the roots that embed intelligent decision‐making and enhance the lifespan of wireless sensor networks (WSNs). Wireless sensors with limited capabilities face several challenges due to the heterogeneous application environments. Especially, the mobility‐incorporated sensors in most situations trouble the cluster network's robustness. Many cluster networking protocols have been presented in the past to enhance the network lifespan and data delivery ratio. However, they lack a dedicated and efficient mechanism for mobility assistance, an adequate cluster management process and cluster head selection criteria. To overcome these issues and for the uniform energy load distribution, we propose a mobility‐compatible cache controlled cluster networking protocol (MC‐CCCNP) in this paper. It is an energy‐efficient cluster networking protocol that supports sensor movement. Network resource management and routing are controlled distributively by an optimal number of cache nodes. It defines a new strategy for cache node deployment based on neighbour density as well as a weight formula for cluster head selection and cluster formation based on the residual energy, the distance to the base station and the node velocity. It also includes techniques for detaching and reconnecting a mobile node to an appropriate cluster cache if it crosses the cluster boundary. We simulate and compare the performance of our protocol with the centralised energy‐efficient clustering routing, energy‐efficient mobility‐based cluster head selection protocol and dual tier cluster‐based routing protocols over different network configurations with varying mobility, scalability and heterogeneity. The MC‐CCCNP showed remarkable improvements in energy utilisation uniformity and energy consumption. With the improved network lifespan, it also maintains a higher data throughput rate of 95% or more in almost all network configurations.
A flexible and interpretable spatial covariance model for data on graphs
Authors: Christensen Michael F. , Hoff Peter D. 
Published: August 2024

AbstractSpatial models for areal data are often constructed such that all pairs of adjacent regions are assumed to have near‐identical spatial autocorrelation. In practice, data can exhibit dependence structures more complicated than can be represented under this assumption. In this article, we develop a new model for spatially correlated data observed on graphs, which can flexibly represented many types of spatial dependence patterns while retaining aspects of the original graph geometry. Our method implies an embedding of the graph into Euclidean space wherein covariance can be modeled using traditional covariance functions, such as those from the Matérn family. We parameterize our model using a class of graph metrics compatible with such covariance functions, and which characterize distance in terms of network flow, a property useful for understanding proximity in many ecological settings. By estimating the parameters underlying these metrics, we recover the “intrinsic distances” between graph nodes, which assist in the interpretation of the estimated covariance and allow us to better understand the relationship between the observed process and spatial domain. We compare our model to existing methods for spatially dependent graph data, primarily conditional autoregressive models and their variants, and illustrate advantages of our method over traditional approaches. We fit our model to bird abundance data for several species in North Carolina, and show how it provides insight into the interactions between species‐specific spatial distributions and geography.
Achieving fairness in the food system
Authors: Onyeaka Helen , Duan Keru , Miri Taghi , Pang Gu , Shiu Eric , Pokhilenko Irina , Ögtem‐Young Özlem , Jabbour Liza , Miles Kathryn , Khan Amil , Foyer Christine H. , Frew Emma , Fu Lin , Osifowora Bisola 
Published: August 2024

AbstractThe challenge of feeding an additional 2 billion people by 2050 is one of the most pressing issues of our generation. The required changes in the current food system must be achieved while reducing the negative environmental impacts of current farming practices on our climate and biodiversity and avoiding deforestation. This formidable challenge must be overcome in a projected climate that is more variable and where extreme weather events are increasingly common. While the green revolution, agricultural land expansion and agrotechnological innovations have significantly increased crop productivity over the last 50 years, the gains in the yields of most major crops have reached a plateau. Moreover, global hunger remains at a record high. Climate change‐associated changes in weather patterns have decreased the yields of major crops. Further land expansion is impossible without severe trade‐offs with biodiversity and climate change mitigation. Wars and pandemics are currently severely disrupting the global agri‐food system, increasing prices and exacerbating food insecurity, with the world's poorest suffering the most. The climate change–social instability nexus will continue to cause additional stress to the agri‐food system. Here, we consider the inequities in the current food system, highlighting the weak interconnection among research, policy and societal action that is hindering mitigation and adaptation efforts. We argue that improved interconnections among research, policy, governance and societal action will unlock the potential to achieve food security while supporting climate change mitigation targets. Our analysis includes specific strategies such as strengthening small‐scale farmers, promoting fair trade practices and reducing food waste to achieve these goals.
A study on degradation and CO2 capture performance of aqueous amino acid salts for direct air capture applications
Authors: Kiani Ali , Conway Will , Abdellah Mohamed H. , Puxty Graeme , Minor Ann‐Joelle , Kluivers Gerard , Bennett Robert , Feron Paul 
Published: August 2024

AbstractWe have previously proposed amino acid salts solutions as potential absorption liquids for direct air capture (DAC) of CO2 from the atmosphere. However, little is known about their relevant CO2 solubilities, CO2 mass transfer rates, and susceptibility to oxidative and thermal degradation under conditions relevant to DAC. We report here on the overall solubility of CO2 and CO2 mass transfer rates into a series of amino acid salts solutions. Additionally, the robustness of various amino acid salt solutions to thermal and oxidative degradation has been assessed.CO2 absorption rates into the amino acid salts solutions were observed to be in the same order of magnitude as aqueous monoethanolamine (MEA), with sarcosinate and lysinate solutions providing the fastest and slowest CO2 mass transfer rates at 25°C, respectively. Degradation data revealed that all amino acid salt solutions investigated in this study displayed elevated rates of thermal degradation at both 120 and 150°C relative to MEA. The opposite trend was observed with respect to oxidative degradation where all amino acid salt solutions showed a greater resistance to oxidative degradation than that observed for MEA under the conditions investigated here. Considering the degradation, CO2 absorption capacity, and CO2 mass transfer rate data, we propose the potassium salts of proline and sarcosine as the most promising amino acid salts (of those considered here) for further evaluation in DAC processes. Overall, this study provides valuable insight into the suitability of various amino acid salt solutions as absorption liquid for DAC. © 2024 The Author(s). Greenhouse Gases: Science and Technology published by Society of Chemical Industry and John Wiley & Sons Ltd.
TMEM252 inhibits epithelial–mesenchymal transition and progression in papillary thyroid carcinoma by regulating Notch1 expression
Authors: Zhang Shuyong , Xie Rong , Wang Liuhuan , Fu Guoxue , Zhang Chenxi , Zhang Yang , Yu Jichun 
Published: August 2024

AbstractBackgroundPapillary thyroid carcinoma (PTC) accounts for about 85% of thyroid cancer cases. Transmembrane protein 252 (TMEM252) is a gene encoding a transmembrane protein that has only been reported to be associated with triple‐negative breast cancer. Herein, we first elucidated the physiological roles and possible regulatory proteins of TMEM252 in PTC pathogenesis.MethodsQuantitative real‐time polymerase chain reaction, western blot, and immunohistochemical analyses were utilized to ascertain the relative TMEM252 expression in PTC and surrounding normal tissues. Functional investigations involved CCK‐8 viability assay, EdU incorporation assay for proliferation, transwell assays for migration and invasion, and an in vivo tumor development assessment to evaluate the TMEM252‐mediated regulation of tumor formation.ResultsOur results first revealed diminished TMEM252 transcript and protein expressions in PTC tissues and cell lines. TMEM252 overexpression suppressed cell proliferation through reducing p53, p21, and p16 expression. Conversely, TMEM252 depletion has opposite effects in PTC cells both in vivo. Additionally, the upregulation of TMEM252 demonstrated cell migration and invasion suppression by impeding the epithelial–mesenchymal transition (EMT) process via inhibition of the Notch pathway. Furthermore, overexpression of TMEM252 suppressed tumor growth in vivo.ConclusionOur study elucidates that TMEM252 suppresses PTC progression by modulating the Notch pathway. These findings underscore TMEM252 is a potential therapeutic target in managing PTC.