bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hysterosalpingography vs Hysteroscopy: Role in Assessment of Uterine Factor during Infertility Workup
Authors: Malhotra Vani , Chauhan Meenakshi Barsaul , Lakra Pinkey , Sangwan Roopa 
Published: March 2014

ABSTRACTObjectiveUterine pathologies are the cause of infertility in 15% of infertile couples and their correction is associated with improved pregnancy rates. This prospective study was carried out to compare hysterosalpingography (HSG) with hysteroscopy (HSC) in evaluation of uterine pathology.Study designThe research was approved by the institutional review board. A total of 100 infertile women were included in the study. HSC and HSG were performed in the follicular phase and the findings were compared. Student's t test and chi-square test were applied wherever applicable. Degree of agreement between the two procedures was calculated using kappa estimates.ResultsThirteen percent of the women had abnormal HSG regarding the uterine cavity while 20% had abnormal HSC findings (chi-square value 1.77, p > 0.05). Out of 10% women who had normal HSG, some abnormality was found on HSC. Similarly 3% women with abnormal HSG had normal findings on HSC. Sensitivity of HSG in detecting uterine cavity abnormality was 50% and specificity 98.1%. Positive predictive value was 76.9% and negative predictive value was 88.5%. Result of HSG was false-negative in 10% of women and false-positive in 3%.ConclusionHysteroscopy should be considered essential while investigating infertile women., Since HSG provides valuables information about tubes, it may supplement the hysteroscopic assessment.How to cite this articleChauhan MB, Lakra P, Sangwan R, Nanda S, Malhotra V. Hysterosalpingography vs Hysteroscopy: Role in Assessment of Uterine Factor during Infertility Workup. Int J Infertility Fetal Med 2013;4(3):79-82.
Greywater Characteristics In Rural Areas of the Sahelian Region for Reuse Purposes: The Case of Burkina Faso
Authors: Maiga Ynoussa , Moyenga David , Ushijima Ken , Sou Mariam , Maiga Amadou Hama 
Published: March 2014

The characteristics of greywater generated in two rural areas (“Barkoundba” and “Kologoudiessé”) located in the Sahelian region in Burkina Faso were assessed through observations in selected concessions, sample collection and laboratory analyses. The study aimed at characterizing the qualitative and quantitative characteristics of greywater in order to evaluate its reuse potential for gardening in rural areas. The results showed that greywater is generated from 3 to 4 main sources with average daily productions of 8 ± 1 L•capita‑1•d‑1 in “Barkoundba” and 13 ± 3 L•capita‑1•d‑1 in Kologoudiessé”. Despite these low rates, the average quantity of greywater production varied from 67 to 344 L•concession‑1•d‑1 during the dry season. This greywater can be collected to provide additional water for irrigation in home gardens of size varying from 10 to 43 m2. Shower activity is the major contributor of greywater with up to 56% in “Barkoundba” and 70% in “Kologoudiessé”. The qualitative assessment of the greywater streams showed that every source is contaminated with chemicals and microbial pollutants at levels not suitable for direct reuse in agriculture. Therefore, it is recommended to treat the greywater before its use for irrigation purposes. Based on World Health Organization (WHO) reuse guidelines, the treatment system should be able to remove bacteria by more than 2 log units and 4 log units if restricted and unrestricted irrigation are considered respectively. Since shower greywater is directly poured onto the ground, the treatment unit should be adapted to the shower room to allow shower greywater collection, in order to collect the required quantities for gardening. A slanted soil treatment system could be investigated. Hazards of a direct reuse are discussed for soils, plants and human health on the basis of the various qualitative parameters. However, an accurate risk assessment would require further investigations with the evaluation of the interannual variability of greywater quality.
Internet, nouvel eldorado pour la circulation de la production audiovisuelle autochtone ?
Authors: George Éric , Lupien Philippe-Antoine 
Published: March 2014

La popularité grandissante des médias sociaux a réactualisé un discours présent depuis les débuts du réseau Internet, selon lequel les usagers du cyberespace, contribuant à la production du contenu en ligne, participent à l’essor de nouvelles structures de production appelées à révolutionner les industries de la culture. En quittant le simple statut de consommateur pour devenir générateur de contenu, l’internaute contribuerait activement au développement culturel de sa communauté et à la circulation de nouvelles formes de productions. En s’intéressant au rôle tenu par le réseau Internet dans la circulation de la production culturelle autochtone au Québec et au Canada, l’auteur a observé en quoi le cyberespace permet d’enrichir la production traditionnelle et comment le Web contribue à diversifier l’offre et à modifier les usages. En somme, dans quelle mesure les nouveaux moyens de communication contribuent- ils à élargir la prise de parole ou à renforcer la domination de médias déjà existants ?
Obesity and Early-Onset Breast Cancer and Specific Molecular Subtype Diagnosis in Black and White Women
Authors: Sudan Sarabjeet Kour , Sharma Amod , Vikramdeo Kunwar Somesh , Davis Wade , Deshmukh Sachin K. , Poosarla Teja , Holliday Nicolette P. , Prodduturvar Pranitha , Nelson Cindy , Singh Karan P. , Singh Ajay P. , Singh Seema 
Published: July 2024

ImportanceEpidemiologic data suggest an association of obesity with breast cancer (BC); however, obesity’s contribution to early onset and risk of diagnosis with specific molecular subtypes by race is uncertain.ObjectiveTo examine the race-specific association of body mass index with early onset and diagnosis of specific molecular subtypes.Design, Setting, and ParticipantsThis retrospective cohort study included patients with BC diagnosed between October 1, 2017, and March 31, 2022, at 3 University of South Alabama Mitchell Cancer Institute clinics. Participants were also prospectively enrolled for serum leptin measurement.Main Outcomes and MeasuresThe primary outcome was age at BC onset and specific subtype diagnosis. The secondary outcome was race-specific differences. Odds ratios (ORs) for associations of body mass index with age at onset and subtype were estimated using the Fisher exact test. Race was self-reported.ResultsOf the 1085 study patients, 332 (30.6%) were Black with a median age of 58 (IQR, 50-66) years, and 753 (69.4%) were White with a median age of 63 (IQR, 53-71) years. A total of 499 patients (46.0%) had obesity, with Black women with obesity receiving more frequent BC diagnosis than their White counterparts (OR, 2.40; 95% CI, 1.87-3.15; P &amp;lt; .001). In addition, Black women had a significantly higher incidence of early-onset disease (OR, 1.95; 95% CI, 1.33-2.86; P = .001) than White women, and obesity increased this risk significantly in Black women (OR, 2.92; 95% CI, 1.35-6.22; P = .006). Black women with obesity also had a significantly higher risk of luminal A BC (OR, 2.53; 95% CI, 1.81-3.56; P &amp;lt; .001) and triple-negative BC (TNBC) (OR, 2.48; 95% CI, 1.43-4.22; P = .002) diagnosis than White counterparts. Black women, with or without BC, had significantly higher serum leptin levels (median [IQR], 55.3 [40.3-66.2] ng/mL and 29.1 [21.1-46.5] ng/mL, respectively, P &amp;lt; .001) than White women (median [IQR], 33.4 [18.9-47.7] ng/mL and 16.5 [10.0-22.9] ng/mL, respectively), which was associated with higher odds of luminal A disease (OR, 5.25; 95% CI, 1.69-14.32, P = .003). Higher odds of early-onset disease (OR, 3.50; 95% CI, 0.43-23.15; P = .33 for trend), and TNBC diagnosis (OR, 6.00; 95% CI, 0.83-37.27; P = .14 for trend) were also seen, although these outcomes were not statistically significant.Conclusions and RelevanceIn this cohort study of patients with BC, obesity and high serum leptin levels were associated with an enhanced risk of early-onset BC and diagnosis of luminal A and TNBC subtypes in Black women. These findings should help in developing strategies to narrow the existing disparity gaps.
Childhood Maltreatment and Longitudinal Epigenetic Aging
Authors: Chang Olivia D. , Meier Helen C. S. , Maguire-Jack Kathryn , Davis-Kean Pamela , Mitchell Colter 
Published: July 2024

ImportanceChild physical and emotional abuse and neglect may affect epigenetic signatures of accelerated aging several years after the exposure.ObjectiveTo examine the longitudinal outcomes of early-childhood and midchildhood exposures to maltreatment on later childhood and adolescent profiles of epigenetic accelerated aging.Design, Setting, and ParticipantsThis cohort study used data from the Future of Families and Child Wellbeing Study (enrolled 1998-2000), a US birth cohort study with available DNA methylation (DNAm) data at ages 9 and 15 years (assayed between 2017 and 2020) and phenotypic data at birth (wave 1), and ages 3 (wave 3), 5 (wave 4), 9 (wave 5), and 15 (wave 6) years. Data were analyzed between June 18 and December 10, 2023.ExposuresEmotional aggression, physical assault, emotional neglect, and physical neglect via the Parent-Child Conflict Tactics Scale at ages 3 and 5 years.Main Outcomes and MeasuresEpigenetic accelerated aging (DNAmAA) was measured using 3 machine learning–derived surrogates of aging (GrimAge, PhenoAge, and DunedinPACE) and 2 machine learning–derived surrogates of age (Horvath and PedBE), residualized for age in months.ResultsA total of 1971 children (992 [50.3%] male) representative of births in large US cities between 1998 and 2000 were included. Physical assault at age 3 years was positively associated with DNAmAA for PhenoAge (β = 0.073; 95% CI, 0.019-0.127), and emotional aggression at age 3 years was negatively associated with PhenoAge DNAmAA (β = −0.107; 95% CI, −0.162 to −0.052). Emotional neglect at age 5 years was positively associated with PhenoAge DNAmAA (β = 0.051; 95% CI, 0.006-0.097). Cumulative exposure to physical assault between ages 3 and 5 years was positively associated with PhenoAge DNAmAA (β = 0.063; 95% CI, 0.003-0.123); emotional aggression was negatively associated with PhenoAge DNAmAA (β = −0.104; 95% CI, −0.165 to −0.043). The association of these measures with age 15 years PhenoAge DNAmAA was almost fully mediated by age 9 years PhenoAge DNAm age acceleration. Similar patterns were found for GrimAge, DunedinPACE, and PhenoAge, but only those for PhenoAge remained after adjustments for multiple comparisons.Conclusions and RelevanceIn this cohort study, altered patterns of DNAmAA were sensitive to the type and timing of child maltreatment exposure and appeared to be associated with more proximate biological embedding of stress.
Harnessing Dual Phototherapy and Immune Activation for Cancer Treatment: The Development and Application of BODIPY@F127 Nanoparticles
Authors: Peng Yang , Hu Chenyan , Zhang Ludan , Dong Fan , Li Ruwan , Liang Huihui , Dai Hao , Jang Won Jun , Cheng Hong‐Bo , Zhou Liming , Wang Yuguang , Yoon Juyoung 
Published: July 2024

AbstractConventional phototherapeutic agents are typically used in either photodynamic therapy (PDT) or photothermal therapy (PTT). However, efficacy is often hindered by hypoxia and elevated levels of heat shock proteins in the tumor microenvironment (TME). To address these limitations, a formylated, near‐infrared (NIR)‐absorbing and heavy‐atom‐free Aza‐BODIPY dye is presented that exhibits both type‐I and type‐II PDT actions with a high yield of reactive oxygen species (ROS) and manifests efficient photothermal conversion by precise adjustments to the conjugate structure and electron distribution, leading to a large amount of ROS production even under severe hypoxia. To improve biosafety and water solubility, the dye with an amphiphilic triblock copolymer (Pluronic F‐127), yielding BDP‐6@F127 nanoparticles (NPs) is coated. Furthermore, inspired by the fact that phototherapy triggers the release of tumor‐associated antigens, a strategy that leverages potential immune activation by combining PDT/PTT with immune checkpoint blockade (ICB) therapy to amplify the systemic immune response and achieve the much‐desired abscopal effect is developed. In conclusion, this study presents a promising molecular design strategy that integrates multimodal therapeutics for a precise and effective approach to cancer therapy.
Two‐Regime Conformation of Grafted Polymer on Nanoparticle Determines Symmetry of Nanoparticle Self‐Assembly
Authors: Yu Ji Woong , Yun Hongseok , Lee Won Bo , Kim YongJoo 
Published: July 2024

AbstractOne of the key design factors that regulate the properties of grafted nanoparticles (GNPs) and their self‐assembly is the conformation of the grafted polymer. On the curved surface of the GNP core, the conformation of the polymer chain is not uniform in the radial direction. The segment is a non‐Gaussian chain in the concentrated polymer brush (CPB) regime near the interface between GNP core and grafted polymer, while it is less constrained in the semidilute polymer brush (SDPB) regime near the surface of GNP. Here, the property of polymer conformation showing crossover behavior at the CPB/SDPB threshold through the coarse‐grain molecular dynamics simulation of nanoparticles with explicit grafted chains is explored. Moreover, the self‐assembly structure depends on the effective softness, which is defined as a function of the threshold of two regimes estimated from the conformation of the polymer.
Effect of Substrate on Spin‐Wave Propagation Properties in Ferrimagnetic Thulium Iron Garnet Thin Films
Authors: Timalsina Rupak , Giri Bharat , Wang Haohan , Erickson Adam , Sarin Suchit , Lamichhane Suvechhya , Liou Sy‐Hwang , Shield Jeffrey E. , Xu Xiaoshan , Laraoui Abdelghani 
Published: July 2024

AbstractRare‐earth iron garnets have distinctive spin‐wave (SW) properties such as low magnetic damping and long SW coherence length making them ideal candidates for magnonics. Among them, thulium iron garnet (TmIG) is a ferrimagnetic insulator with unique magnetic properties including perpendicular magnetic anisotropy (PMA) and topological hall effect at room temperature when grown down to a few nanometers, extending its application to magnon spintronics. Here, the SW propagation properties of TmIG films (thickness of 7–34 nm) grown on GGG and sGGG substrates are studied at room temperature. Magnetic measurements show in‐plane magnetic anisotropy for TmIG films grown on GGG and out‐of‐plane magnetic anisotropy for films grown on sGGG substrates with PMA. SW electrical transmission spectroscopy measurements on TmIG/GGG films unveil magnetostatic surface spin waves (MSSWs) propagating up to 80 µm with a SW group velocity of 2–8 km s−1. Intriguingly, these MSSWs exhibit nonreciprocal propagation, opening new applications in SW functional devices. TmIG films grown on sGGG substrates exhibit forward volume spin waves with a reciprocal propagation behavior up to 32 µm.
Dinitropyridines: Synthesis and Reactions
Authors: Starosotnikov Alexey M. , Bastrakov Maxim A. 
Published: July 2024

AbstractDinitropyridines are one of the promising classes of heterocyclic compounds. They are considered as useful precursors of explosives and energetic compounds, agrochemicals, biosensors and biologically active compounds with diverse properties: antitumor, antiviral, anti‐neurodegenerative. Preliminary analysis of literature data shows that the chemistry of polynitropyridines has been actively developing over the past few decades. This is evidenced by the steadily growing annual number of publications. In this review the literature on the synthesis, reactions and practical application of isomeric dinitropyridines over a period of 2010–2024 is analyzed.
Neurometabolic topography and associations with cognition in Alzheimer's disease: A whole‐brain high‐resolution 3D MRSI study
Authors: Hu Jialin , Zhang Miao , Zhang Yaoyu , Zhuang Huixiang , Zhao Yibo , Li Yudu , Jin Wen , Qian Xiao‐Hang , Wang Lijun , Ye Guanyu , Tang Huidong , Liu Jun , Li Biao , Nachev Parashkev , Liang Zhi‐Pei , Li Yao 
Published: July 2024

AbstractINTRODUCTIONAltered neurometabolism, detectable via proton magnetic resonance spectroscopic imaging (1H‐MRSI), is spatially heterogeneous and underpins cognitive impairments in Alzheimer's disease (AD). However, the spatial relationships between neurometabolic topography and cognitive impairment in AD remain unexplored due to technical limitations.METHODSWe used a novel whole‐brain high‐resolution 1H‐MRSI technique, with simultaneously acquired 18F‐florbetapir positron emission tomography (PET) imaging, to investigate the relationship between neurometabolic topography and cognitive functions in 117 participants, including 22 prodromal AD, 51 AD dementia, and 44 controls.RESULTSProdromal AD and AD dementia patients exhibited spatially distinct reductions in N‐acetylaspartate, and increases in myo‐inositol. Reduced N‐acetylaspartate and increased myo‐inositol were associated with worse global cognitive performance, and N‐acetylaspartate correlated with five specific cognitive scores. Neurometabolic topography provides biological insights into diverse cognitive dysfunctions.DISCUSSIONWhole‐brain high‐resolution 1H‐MRSI revealed spatially distinct neurometabolic topographies associated with cognitive decline in AD, suggesting potential for noninvasive brain metabolic imaging to track AD progression.Highlights
Whole‐brain high‐resolution 1H‐MRSI unveils neurometabolic topography in AD.
Spatially distinct reductions in NAA, and increases in mI, are demonstrated.
NAA and mI topography correlates with global cognitive performance.
NAA topography correlates with specific cognitive performance.
Improving Compliance With Evidence‐Based Laboratory Testing Recommendations and Monitoring Associated Patient Outcomes
Authors: Hawkins Alexandra , Moynihan Ann Marie , Glassman Kimberly , Clarke Sean 
Published: July 2024

ABSTRACTA team comprising nursing, medical staff, and administrative leaders at an urban academic orthopedic hospital in the northeastern United States sought to revise a preoperative laboratory testing protocol based on evidence and practice guidelines. The goal was to decrease unnecessary tests by 20% without negatively affecting patient outcomes. After adding the revised protocol to the electronic health record, audits revealed that the target goal was not met and additional strategies were implemented, including educational webinars for surgeon office personnel who ordered tests, additional webinars for advanced practice professionals, and the creation of scorecards to track surgeons’ progress. Overall, a downward trend in the ordering of unnecessary laboratory tests for patients without identified risks was observed, but a 20% reduction was not achieved. Surgical complications during the project were not associated with laboratory tests. Clinicians continue to use the revised preoperative laboratory testing protocol at the facility.
X centromeric drive may explain the prevalence of polycystic ovary syndrome and other conditions
Authors: Moore Tom 
Published: July 2024

AbstractX chromosome centromeric drive may explain the prevalence of polycystic ovary syndrome and contribute to oocyte aneuploidy, menopause, and other conditions. The mammalian X chromosome may be vulnerable to meiotic drive because of X inactivation in the female germline. The human X pericentromeric region contains genes potentially involved in meiotic mechanisms, including multiple SPIN1 and ZXDC paralogs. This is consistent with a multigenic drive system comprising differential modification of the active and inactive X chromosome centromeres in female primordial germ cells and preferential segregation of the previously inactivated X chromosome centromere to the polar body at meiosis I. The drive mechanism may explain differences in X chromosome regulation in the female germlines of the human and mouse and, based on the functions encoded by the genes in the region, the transmission of X pericentromeric genetic or epigenetic variants to progeny could contribute to preeclampsia, autism, and differences in sexual differentiation.
Naphthalimide‐Based, Single‐Chromophore, Emission Ratiometric Fluorescent Sensor for Tracking Intracellular pH
Authors: Kumar Das Sujit , Kahali Smitaroopa , Kar Sabnam , Madhavan Nandita , Datta Ankona 
Published: July 2024

AbstractWe report a novel, reversible, cell‐permeable, pH‐sensor, TRapH. TRapH afforded a pH‐sensitive ratiometric emission response in the pH range ~3–6, enabling imaging and quantification of pH in living cells. The biological‐applicability of TRapH was illustrated via live‐tracking of intracellular pH dynamics in living mammalian cells induced by a synthetic H+‐transporter.
Adaptable Synthesis of Chondroitin Sulfate Disaccharide Subtypes Preprogrammed for Regiospecific O‐Sulfation
Authors: Wootton Hannah S. , Berry Sian S. , Ferguson Elaine L. , Mahon Clare S. , Miller Gavin J. 
Published: July 2024

AbstractA divergent synthetic route to chondroitin sulfate (CS) disaccharide precursors, including rarer subtypes such as CS−D, has been developed. From common intermediates, a series of thioglycoside D‐glucosyl donors and 4,6‐O‐benzylidene protected D‐galactosamine acceptors are utilised in a robust glycosylation reaction, achieving β‐selectivity and consistent yields (60–75 %) on scales >2.0 g. A post‐glycosylation oxidation to D‐glucuronic acid and orthogonal protecting groups delivers access to CS−A, CS−C, CS−D, CS−E and CS−O precursor subtypes. Of further note is a 4‐O‐benzyl regioselective reductive ring opening of a 4,6‐O‐benzylidene protected disaccharide using dichlorophenylborane (PhBCl2) and triethylsilane (Et3SiH) to access a CS−D precursor, in 73 % yield over two steps. Finally, synthesis of a 6‐O‐sulfated CS−C disaccharide containing a conjugable anomeric allyl tether is completed. These materials will provide a benchmark to further synthesise and study chondroitin sulfates.
Investigation of physical properties of microalgae‐pectin‐based bio‐composite with addition of pine needle for environmental application
Authors: Munoz‐Cupa Carlos , Lee Kristine , Krishnan Anuradha , Bassi Amarjeet 
Published: July 2024

AbstractPolymers and biopolymers have gained significance due to their applicability and use in industry reducing the negative impact of polymers based on petroleum. A possible solution for the conventional polymer's biodegradability is bio‐composites, which contain natural fibers or aggregates such as microalgae. Hence, microalgae biomass has a promising application to address the biodegradability issue of conventional polymers. In this study, Chlorella vulgaris biomass was mixed with pectin for control samples with glycerol as plasticizer. The mixture microalgae‐pectin‐glycerol, and the addition of pine needles was used to evaluate the tensile strength and compression of the bio‐composite. This bio‐composite showed a higher Young's modulus of 95.66 MPa for blend C2 and a higher strength with 20% of pectin concentration in the mixture. Additionally, the pine needle addition did not have a low effect between the compression results. On the other hand, analysis on elasticity showed that the full recovery of the bio‐composite happened after 10 min in all the blends. Also, the bio‐composite showed a slow release of nitrogen and phosphorous after 5 days of water addition, indicating an effective slow release for blend B for both nutrients. Water uptake capacity and loss of soluble material was studied using pullulan, chitosan, and cetyltrimethylammonium bromide additives. These cationic surfactants demonstrated their potential for reduction of water solubility of the bio‐composite.