bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health Care Use of Patients With Osteoarthritis of the Hip or Knee After Implementation of a Stepped‐Care Strategy: An Observational Study
Authors: Smink Agnes J. , Dekker Joost , Vliet Vlieland Thea P. M. , Swierstra Bart A. , Kortland Joke H. , Bijlsma Johannes W. J. , Teerenstra Steven , Voorn Theo B. , Bierma‐Zeinstra Sita M. A. , Schers Henk J. , van den Ende Cornelia H. M. 
Published: October 2013

ObjectiveTo enhance guideline‐based nonsurgical management of osteoarthritis (OA), a multidisciplinary stepped‐care strategy has been implemented in clinical practice. This study aimed to describe health care use after implementation of this strategy and to identify factors related to such use at multiple levels.MethodsFor this 2‐year observational prospective cohort, patients with symptomatic hip or knee OA were included by their general practitioner. Activities aligned with patients and health care providers were executed to implement the strategy. Health care use was described as the cumulative percentage of “users” for each modality recommended in the strategy. Determinants were identified at the level of the patient, general practitioner, and practice using backward stepwise logistic multilevel regression models.ResultsThree hundred thirteen patients were included by 70 general practitioners of 38 practices. Their mean ± SD age was 64 ± 10 years and 120 (38%) were men. The most frequently used modalities were education, acetaminophen, lifestyle advice, and exercise therapy, which were used by 242 (82%), 250 (83%), 214 (73%), and 187 (63%) patients, respectively. Fourteen percent of the overweight patients reported being treated by a dietician. Being female, having an active coping style, using the booklet “Care for Osteoarthritis,” and having limitations in functioning were recurrently identified as determinants of health care use.ConclusionAfter implementation of the stepped‐care strategy, most recommended nonsurgical modalities seem to be well used. Health care could be further improved by providing dietary therapy in overweight patients and making more efforts to encourage patients with a passive coping style to use nonsurgical modalities.
Cost Effectiveness of Duloxetine for Osteoarthritis: A Quebec Societal Perspective
Authors: Wielage Ronald C. , Patel Ankur J. , Bansal Megha , Lee Shannon , Klein Robert W. , Happich Michael 
Published: October 2013

ObjectiveTo assess the cost effectiveness of duloxetine compared to other oral postacetaminophen treatments for osteoarthritis (OA) from a Quebec societal perspective.MethodsA cost‐utility analysis was performed enhancing the Markov model from the 2008 OA guidelines of the National Institute for Health and Clinical Excellence (NICE). The NICE model was extended to include opioid and antidepressant comparators, adding titration, discontinuation, and relevant adverse events (AEs). Comparators included duloxetine, celecoxib, diclofenac, naproxen, hydromorphone, and oxycodone extended release (oxycodone). AEs included gastrointestinal and cardiovascular events associated with nonsteroidal antiinflammatory drugs (NSAIDs), as well as fracture, opioid abuse, and constipation, among others. Costs and incremental cost‐effectiveness ratios (ICERs) were estimated in 2011 Canadian dollars. The base case modeled a cohort of 55‐year‐old patients with OA for a 12‐month period of treatment, followed by treatment from a basket of post‐discontinuation oral therapies until death. Sensitivity analyses (one‐way and probabilistic) were conducted.ResultsOverall, naproxen was the least expensive treatment, whereas oxycodone was the most expensive. Duloxetine accumulated the highest number of quality‐adjusted life years (QALYs), with an ICER of $36,291 per QALY versus celecoxib. Duloxetine was dominant over opioids. In subgroup analyses, ICERs for duloxetine versus celecoxib were $15,619 and $20,463 for patients at high risk of NSAID‐related AEs and patients ages ≥65 years, respectively.ConclusionDuloxetine was cost effective for a cohort of 55‐year‐old patients with OA, and more so in older patients and those with greater AE risks.
Mukaiyama Aldol Reactions in Aqueous Media
Authors: Kitanosono Taku , Kobayashi Shū 
Published: October 2013

AbstractMukaiyama aldol reactions in aqueous media have been surveyed. While the original Mukaiyama aldol reactions entailed stoichiometric use of Lewis acids in organic solvents under strictly anhydrous conditions, Mukaiyama aldol reactions in aqueous media are not only suitable for green sustainable chemistry but are found to produce singular phenomena. These findings led to the discovery of a series of water‐compatible Lewis acids such as lanthanide triflates in 1991. Our understanding on these beneficial effects in the presence of water will be deepened through the brilliant examples collected in this review.magnified image
Ontogenetic scaling of the human nose in a longitudinal sample: Implications for genus Homo facial evolution
Authors: Holton Nathan E. , Yokley Todd R. , Froehle Andrew W. , Southard Thomas E. 
Published: October 2013

ABSTRACTResearchers have hypothesized that nasal morphology, both in archaic Homo and in recent humans, is influenced by body mass and associated oxygen consumption demands required for tissue maintenance. Similarly, recent studies of the adult human nasal region have documented key differences in nasal form between males and females that are potentially linked to sexual dimorphism in body size, composition, and energetics. To better understand this potential developmental and functional dynamic, we first assessed sexual dimorphism in the nasal cavity in recent humans to determine when during ontogeny male‐female differences in nasal cavity size appear. Next, we assessed whether there are significant differences in nasal/body size scaling relationships in males and females during ontogeny. Using a mixed longitudinal sample we collected cephalometric and anthropometric measurements from n = 20 males and n = 18 females from 3.0 to 20.0+ years of age totaling n = 290 observations. We found that males and females exhibit similar nasal size values early in ontogeny and that sexual dimorphism in nasal size appears during adolescence. Moreover, when scaled to body size, males exhibit greater positive allometry in nasal size compared to females. This differs from patterns of sexual dimorphism in overall facial size, which are already present in our earliest age groups. Sexually dimorphic differences in nasal development and scaling mirror patterns of ontogenetic variation in variables associated with oxygen consumption and tissue maintenance. This underscores the importance of considering broader systemic factors in craniofacial development and may have important implications for the study of patters craniofacial evolution in the genus Homo. Am J Phys Anthropol 153:52–60, 2014. © 2013 Wiley Periodicals, Inc.
Antimicrobial activity and biodegradation behavior of poly(butylene adipate‐co‐terephthalate)/clay nanocomposites
Authors: Mondal Dibyendu , Bhowmick Biplab , Mollick Md. Masud R. , Maity Dipanwita , Ranjan Saha Nayan , Rangarajan Vivek , Rana Dipak , Sen Ramkrishna , Chattopadhyay Dipankar 
Published: October 2013

AbstractPoly(butylene adipate‐co‐terephthalate) (PBAT) nanocomposites films are prepared by a solution intercalation process using natural montmorillonite (MMT) and cetyltrimethylammonium bromide (CTAB)‐modified montmorillonite (CMMT). Cation exchange technique has been used for modification of MMT by CTAB and characterized by Fourier transform infrared analysis, thermo‐gravimetric analysis, and X‐ray diffraction (XRD) studies. CMMT gives better dispersion in the PBAT matrix than MMT and is confirmed by XRD and transmission electron microscopy. Because of better compatibility of CMMT, water vapor transmission rate of PBAT decreases more in the presence of CMMT than MMT. The biodegradability of PBAT and its nanocomposite films are studied in compost and from the morphological analysis it is apparent that the PBAT/CMMT shows a lower biodegradation rate in comparison to the PBAT/MMT. The antimicrobial activity of PBAT and its nanocomposite films is tested by an inhibition zone method. Because of the presence of the quaternary ammonium group of CTAB‐modified MMT, PBAT/CMMT nanocomposites show adequate antimicrobial activity. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40079.
Critical Role of Endoplasmic Reticulum Aminopeptidase 1 in Determining the Length and Sequence of Peptides Bound and Presented by HLA–B27
Authors: Chen Liye , Fischer Roman , Peng Yanchun , Reeves Emma , McHugh Kirsty , Ternette Nicola , Hanke Tomas , Dong Tao , Elliott Tim , Shastri Nilabh , Kollnberger Simon , James Edward , Kessler Benedikt , Bowness Paul 
Published: October 2013

ObjectiveHLA–B27 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are the two strongest genetic factors predisposing to ankylosing spondylitis (AS). A key aminopeptidase in class I major histocompatibility complex presentation, ERAP1 potentially contributes to the pathogenesis of AS by altering HLA–B27 peptide presentation. The aim of this study was to analyze the effects of ERAP1 on the HLA–B27 peptide repertoire and peptide presentation to cytotoxic T lymphocytes (CTLs).MethodsERAP1‐silenced and ‐competent HeLa.B27 and C1R.B27 cells were isotope‐labeled, mixed, lysed, and then immunoprecipitated using W6/32 or ME1 antibodies. Peptides bound to HLA–B27 were eluted and analyzed by tandem mass spectrometry. Selected peptides were synthesized and tested for HLA–B27 binding ability. The effect of ERAP1 silencing/mutation on presentation of an immunodominant viral HLA–B27 epitope, KK10, to CTLs was also studied.ResultsIn both HeLa.B27 and C1R.B27 cells, the proportion of 9‐mer HLA–B27–bound peptides was decreased by ERAP1 silencing, whereas the percentages of longer peptides (11–13 mer) were increased. Surprisingly, following ERAP1 silencing, C‐terminally extended peptides were readily identified. These were better able to bind to HLA–B27 than were N‐terminally extended peptides lacking an arginine at position 2. In both HeLa.B27 cells and mouse fibroblasts expressing HLA–B27, the absence of ERAP1 reduced peptide recognition by HLA–B27–restricted KK10‐specific CTLs following infection with recombinant vaccinia virus or transfection with minigenes expressing KK10 precursors. Presence of an AS‐protective variant of ERAP1, K528R, as compared to wild‐type ERAP1, reduced the peptide recognition by KK10 CTLs following transfection with extended KK10 minigenes.ConclusionThese results show that ERAP1 directly alters peptide binding and presentation by HLA–B27, thus demonstrating a potential pathogenic mechanism in AS. Inhibition of ERAP1 could potentially be used for treatment of AS and other ERAP1‐associated diseases.
Comparison of early and late outcomes of TAVI alone compared to TAVI plus PCI in aortic stenosis patients with and without coronary artery disease
Authors: Abramowitz Yigal , Banai Shmuel , Katz Guy , Steinvil Arie , Arbel Yaron , Havakuk Ofer , Halkin Amir , Ben‐Gal Yanai , Keren Gad , Finkelstein Ariel 
Published: October 2013

ObjectivesTo assess the safety and effectiveness of performing percutaneous coronary intervention (PCI) before transcatheter aortic valve implantation (TAVI).BackgroundThe presence of coronary artery disease (CAD) negatively impact procedural outcomes and long‐term survival after (TAVI). The management of obstructive CAD before TAVI is not yet well established.MethodsPatients with severe symptomatic aortic stenosis (AS) (n = 249) that underwent TAVI were divided into two groups: patients with CAD (subdivided to patients treated with TAVI alone and to patients that underwent PCI before TAVI) and patients with isolated AS. Procedural endpoints, device success and adverse events were considered according to the Valve Academic Research Consortium (VARC) definitions.ResultsOf a cohort of 249 consecutive patients with mean age of 83.2 ± 5.5 years, 83 patients with AS + CAD were treated with TAVI alone, 61 patients with AS + CAD underwent PCI before TAVI and 105 patients underwent TAVI for isolated AS. The mean duration of follow‐up was 17 months (range: 6–36 months). Despite a significantly higher logistic EuroScore of the AS+CAD group compared to the AS alone group (30.1 vs. 21.1 P < 0. 001), the overall VARC‐adjudicated endpoints did not differ between the groups. All‐cause mortality at 30‐days was 1.6% for patients with AS+CAD treated with PCI compared to 2.9% for patients with AS alone (P = 1).ConclusionsPerforming PCI before TAVI in high‐risk elderly patients with significant CAD and severe AS is feasible and safe. This combined treatment approach did not increase the periprocedural risk for complications or the all‐cause mortality. © 2013 Wiley Periodicals, Inc.
Optical coherence tomography evaluation of late strut coverage patterns between first‐generation drug‐eluting stents and everolimus‐eluting stent
Authors: Toledano Delgado Francisco Javier , Álvarez‐Ossorio Manuel Pan , de Lezo Cruz‐Conde José Suárez , Bellido Francisco Mazuelos , Romero Moreno Miguel Ángel , Fernández‐Aceytuno Alfonso Medina , de Lezo Herrerosde Tejada Javier Suárez , Pineda Soledad Ojeda , Saint‐Gerons José María Segura , Pavlovic Djordje 
Published: October 2013

ObjectivesTo compare strut coverage patterns between everolimus‐eluting stent (EES) and first‐generation drug‐eluting stents (DES) at more than 12 months after successful implantation, using optical coherence tomography (OCT).BackgroundNo sufficient OCT data has been reported comparing late strut coverage patterns between EES and first‐generation DES. The favorable late results after EES implantation could be related to lower rates of uncovered and malapposed struts.MethodsA total of 66 DES (21 EES, 23 SES, and 22 PES) that were implanted at least 1 year in advance in 40 patients and met good late angiographic results were evaluated by OCT. The percentage of uncovered and malapposed struts, calculated as the ratio of uncovered or malapposed struts to total struts in all cross‐sectional images per stent, was compared among the three groups.ResultsA total of 35,061 struts were analyzed: 11,967 from EES, 11,855 from SES, and 11m239 from PES. The average tissue coverage thickness of the struts per stent was greater in EES than in SES and PES (109 ± 40 µm vs. 72 ± 27 µm and 83 ± 26 µm, respectively;P = 0.001). The percentage of uncovered struts (1.9 ± 4.1% in EES vs. 11.6 ± 12.7% in SES,P = 0.01 and vs. 7.1 ± 5.2% in PES,P < 0.001) and malapposed struts (0.1 ± 0.3% in EES vs. 1.8 ± 3.5% in SES,P = 0.01 and vs. 3.5 ± 5.1% in PES,P = 0.02) was much lower in EES than in first‐generation DES, with no significant differences between SES and PES.ConclusionsLate strut coverage patterns are not similar between EES and first‐generation DES. EES showed a lower percentage of uncovered and malapposed struts. © 2013 Wiley Periodicals, Inc.
Long‐term outcome following percutaneous coronary intervention with drug‐eluting stents compared with bare‐metal stents in saphenous vein graft lesions: From Western Denmark heart registry
Authors: Hougaard Mikkel , Thayssen Per , Kaltoft Anne , Tilsted Hans‐Henrik , Maeng Michael , Flensted Lassen Jens , Thuesen Leif , Okkels Jensen Lisette 
Published: October 2013

ObjectivesWe used the Western Denmark Heart Registry to assess one‐year and long‐term all‐cause mortality and stent failure following Percutaneous Coronary Intervention (PCI) with drug‐eluting stents (DES) or bare‐metal stents (BMS).BackgroundThe use of DES compared with BMS during PCI has reduced the risk of restenosis in native coronary artery lesions. In saphenous vein grafts (SVG) the outcome after DES compared with BMS is insufficiently described.MethodsFrom January 1, 2002 to December 31, 2010 all patients with PCI of SVG lesions were identified among 3.0 million inhabitants. Stent failure was defined as clinically driven target lesion revascularization, graft occlusion without intervention, or stent thrombosis.ResultsThe study cohort consisted of 529 patients with 755 SVG lesions (348 DES patients with 510 lesions and 181 BMS patients with 245 lesions). Mean age did not differ between patients with DES‐treated lesions compared to patients with BMS‐treated lesions (67.5 ± 9.1 years vs. 67.6 ± 9.3 years; P = 0.85). The median follow‐up time was 3.0 years (25th–75th percentile: 1.4–5.1 years). One‐year (n = 27 (8.2%) vs. n = 12 (6.7%), log rank P = 0.60) and 3‐year cumulative mortality (n = 31 (18.8%) vs. n = 59 (21.8%), log rank P = 0.64) did not differ significantly between DES‐ and BMS‐treated patients. One‐year cumulative stent failure was seen in 39 (6.6%) DES‐treated lesions vs. 24 (10.8%) BMS‐treated lesions (P = 0.088), and 3‐year cumulative stent failure in 48 (15.4%) vs. 34 (18.8%) lesions (P = 0.25), respectively.ConclusionIn SVG lesions, DES showed no long‐term benefit compared to BMS in rates of all‐cause mortality or stent failure. © 2013 Wiley Periodicals, Inc.
Cu‐Mediated Direct Aryl CH Halogenation: a Strategy to Control Mono‐ and Di‐Selectivity
Authors: Du Zhi‐Jun , Gao Lian‐Xun , Lin Ying‐Jie , Han Fu‐She 
Published: October 2013

AbstractA protocol for the copper‐mediated direct aryl CH halogenation is presented. Highly selective mono‐ and di‐halogenations are achieved by using acyl hypohalites, generated in situ from the readily available carboxylic acid and N‐halosuccinimides (NXS; X=Br and Cl) as powerful halogenating reagents. The correct choice of carboxylic acid additives and solvents is essential for both high yield and selectivity. Consequently, the use of inexpensive Cu catalyst and the new strategy for the in situ generation of acyl hypohalite halogenating reagents from the readily affordable and easily‐to‐handle carboxylic acid and NXS (X=Br and Cl) offers advantages for practical application.
Fluid Dynamics of a Sand‐Biomass Mixture in a Spouted‐Bed Reactor for Fast Pyrolysis
Authors: Santos K. G. , Campos A. V. P. , Ferreira L. V. , Santana R. C. , Barrozo M. A. S. 
Published: October 2013

AbstractThe spouted‐bed reactor represents an interesting alternative to pyrolysis as compared with conventional fluid beds due to its better performance in handling coarse and irregular materials, requiring lower fluidizing flow rates and providing intense thermal contact. The fluid dynamics of a mixture of sand and sugarcane bagasse in a spouted bed was investigated. Since this process involves a mixture of solids of different sizes, shapes, and densities, particle segregation was also analyzed. The results provided significant insights about the segregation phenomenon which may cause severe operating problems during pyrolysis. Various mixture compositions were identified in which the particles exhibited good circulation in the bed.
Polarcardiographic and vectorcardiographic study of 70 normal children aged 3‐4 years
Authors: Niederberger M. , Dower G.E. , Machado H.B. 
Published: October 2013

AbstractThis polarcardiographic and vectorcardiographic study of 70 normal children, aged three to four years using the Frank lead system, provides data on an important age group that were not previously available. High‐resolution xyz signals, recorded on magnetic tape, were edited, digitized, compressed, and fed into a digital computer together with typed information. Computer outputs included measurements, analysis, VCG loops, Aitoff plots of P̌, Ř, and Ť directions, derived 12‐lead ECGs, and polar tracings. Conventional ECGs were also recorded; differences from the derived ECG were not clinically significant. Various normal bounds for polar coordinate variables were established, such as criteria for diagnosing left ventricular hypertrophy. There was a significant sex difference in the Ť directions, which were more posterior than those previously reported for adults. Among the VCGs, it was interesting to note several patterns suggesting persistence of right ventricular forces.
Sustained salutary effects of oral controlled‐release nitroglycerin on ventricular function in congestive heart failure
Authors: Amsterdam E. A. , Awan N. A. , Demaria A. N. , Miller R. R. , Williams D. O. , Mason D. T. 
Published: October 2013

AbstractThe hemodynamic effects of a controlled‐release preparation of original nitroglycerin (ONTG), 6.5 mg to 19.5 mg, were determined during a four hour period in 10 patients with left ventricular failure. After ONTG ingestion left ventricular filling pressure (LVFP) diminished in 20 min (23 to 17 mm Hg, p < 0.01), declined maximally within one hour (15 mm Hg, p < 0.001) and remained decreased (p < 0.02) throughout the four hours. For the entire group no significant alterations (p > 0.05) occurred in systolic blood pressure, heart rate, cardiac index (CI) and peripheral vascular resistance (PVR). However, two subgroups were identified relative to ONTG hemodynamic response. In the four patients in whom LVFP declined but remained substantially elevated (29 to 23 mm Hg, p < 0.05), CI rose (1.7 to 2.1 l/min/m2, p < 0.01) while PVR fell (2074 to 1571 dyne · s · cm‐5, p < 0.02). In contrast, in the six patients with LVFP reductions to 12 mm Hg or less (18 to 10 mm Hg, p < 0.005), CI was unchanged (2.2, p > 0.05) without alteration of PVR (1799, p > 0.05). This investigation provides objective evidence of the salutary hemodynamic effects of ONTG and confirms adequate gastrointestinal absorption with attainment of pharmacologically active blood levels. Moreover, oral sustained‐release nitroglycerin is shown to possess long‐acting peripheral vasodilator actions of considerable value in the treatment of congestive heart failure.
Coronary ostial embolus and mitral vegetation simulating a left atrial myxoma: A case of probable cryptococcal valvulitis
Authors: Child J. S. , Macalpin R. N. , Moyer G. H. , Shanley J. D. , Layfield L. J. 
Published: October 2013

AbstractA 56 year old man died with disseminated cryptococcosis after immunosuppressive therapy for a hematologic disorder of unknown etiology. The immediate cause of death was cardiogenic shock, probably resulting from a large right coronary ostial embolus and subsequent ischemic myocardial injury. The embolus originated from a bulky mitral vegetation (possibly cryptococcal) demonstrated ante mortem by echocardiography and cardiac angiography, and at autopsy. The differential diagnosis of such an echocardiographic pattern is discussed.
Clinical spectrum of “Unstable Angina”
Authors: Bertolasi C. A. , Tronge J. E. , Mon G. A. , Turri D. , Lugones M. I. 
Published: October 2013

AbstractIn order to determine the natural evolution of different clinical types of “unstable angina”, 167 patients were included in a prospective study. After angiography, 11 (6.5%) were excluded because they had no significant coronary lesions. The remaining 156 were sorted into different groups according to their clinical characteristics and were followed up for a period of 24 months at least. After that follow‐up period, mortality and incidence of acute myocardial infarction (AMI) were as follows: angina of recent onset (Class III‐IV NYHA): 8.5% (3/35) and 34.2% (12/35). Progressive angina: 7.4% (2/27) and 7.4% (2/27). Intermediate syndrome: 41.6% (10/24) and 37.5% (9/24).Prinzmetal's angina: 10% (1/10) and 10% (1/10). Post acute myocardial infarction angina: 35% (7/20) and 10% (2/20). Acute persistent ischemia: 2.5% (1/40) and 20% (8/40). Comparison of these figures pointed out significant differences (p < 0.001 for mortality and p < 0.03 for AMI incidence respectively).We conclude that it is clinically possible to identify different groups within the so‐called unstable angina. Such a division not only allows for the creation of more homogeneous groups, but it contributes to a more rational therapeutic approach and also permits identification of high risk prodromes of greater complications, such as myocardial infarction or sudden death.