bluuebunny/crossref_metadata_2025_split huggingface dataset:
SEXUAL CHARACTERISTICS OF INTERCORTICAL RELATIONSHIPS IN THE DELTA RANGE OF THE POWER SPECTRUM WHEN PERFORMING ARBITRARY BIMANUAL PURPOSEFUL MOVEMENTS
Authors: Кононенко Николай Сергеевич , Ткаченко Павел Владимирович 
Published: August 2024

Уровень бимануальной координации у лиц мужского и женского полов представлен разной результативностью, что объясняется особенностями организации сенсомоторной сферы у женщин и мужчин. Процессы возбуждения и торможения являются взаимодополняющими и способствуют эффективному построению двигательной системы. Целью исследования является изучение половых особенностей активации коры в дельта-диапазоне и выявление внутрисистемных корковых взаимосвязей при реализации сложноскоординированных бимануальных движений. Уровень активности мозга оценивался регистрацией дельта-ритма при проведении электроэнцефалографии, а результаты показателя координации — с помощью метода суппортметрии. Выявлены достоверные различия в тормозной активности коры больших полушарий и функциональных взаимосвязях ее центров, что обусловливает различия результирующей эффективности выполнения моторных программ. В женской группе ведущее значение в формировании моторной программы имеет высокая активность в дельта-диапазоне левой фронтальной ассоциативной коры и выраженная связь затылочной и премоторной области справа. У мужчин межполушарная асимметрия с торможением правого полушария способствует более совершенному результату.
The level of bimanual coordination in men and women is represented by different effectiveness, which is explained by the peculiarities of the organization of the sensorimotor sphere in women and men. The processes of excitation and inhibition are complementary and contribute to the effective construction of the motor system. The aim of the study is to study the sexual characteristics of cortical activation in the delta range and to identify intersystem cortical relationships in the implementation of complexly coordinated bimanual movements. The level of brain activity was assessed by recording the delta rhythm during electroencephalography, and the results of the coordination index using the method of supportmetry. Significant differences in the inhibitory activity of the cerebral cortex and the functional relationships of its centers have been revealed, which causes differences in the resulting effectiveness of motor programs. In the female group, high activity in the delta range of the left frontal associative cortex and a pronounced connection between the occipital and premotor regions on the right are of leading importance in the formation of the motor program. In men, hemispheric asymmetry with inhibition of the right hemisphere contributes to a more perfect result.
PATHOPHYSIOLOGY OF HEMOSTASIS (LECTURE)
Authors: Забежинский Михаил Маркович , Балашов Лев Дмитриевич , Пюрвеев Сарнг Саналович , Косова Анна Николаевна 
Published: August 2024

Механизмы развития многих весьма распространенных заболеваний (инфаркт миокарда, инсульт, опухоли, инфекционная патология и др.) связаны с патологическими изменениями в системе гемостаза. Понимание патофизиологии этих нарушений лежит в основе правильной диагностики и эффективного лечения. В данной лекции, предназначенной для студентов медицинских вузов и врачей различных специальностей, кратко изложены базовые представления о структурных компонентах и механизмах функционирования системы гемостаза, представлены основные группы гемостазопатий, описаны виды, причины и механизмы развития геморрагических диатезов, тромбофилических синдромов, тромбогеморрагического синдрома.
The mechanisms of development of many very common diseases (myocardial infarction, stroke, tumors, infectious pathology, and others) are associated with pathological changes in the hemostasis system. Understanding the pathophysiology of these changes is at the heart of proper diagnosis and effective treatment. This lecture, intended for medical students and doctors of various specialties, briefly summarizes the basic ideas about the structural components and mechanisms of the hemostasis system, presents the main groups of hemostasiopathies, describes the types, causes and mechanisms of the development of hemorrhagic diathesis, thrombophilic syndromes, thrombohemorrhagic syndrome.
SARS COV-2 DELTA VARIANT STRUCTURAL PROTEINS: HOMOLOGY WITH OPPORTUNISTIC BACTERIA
Authors: Марьянович Александр Тимурович , Кормилец Дмитрий Юрьевич 
Published: August 2024

Способность SARS CoV-2 уклоняться от иммунного ответа можно считать общепризнанной. Гомология белков коронавируса и человека может быть одним из механизмов иммунного уклонения. Дельта-вариант обязательно имеет структурные особенности, которые объясняют его специфические свойства. Целью нашего исследования было выяснить, изменяют ли мутации, произошедшие в структурных белках дельта-варианта, его гомологию с белками, присутствующими в организме человека, то есть собственно человеческими,&nbsp; бактериальными и пищевыми. Используя инструменты биоинформатики, мы обнаружили гомологию на уровне гептамеров между структурными белками дельта-варианта и белками человека, а также белками некоторых условно-патогенных бактерий верхних дыхательных путей, легких и кишечника. Белки шиповый (S) и мембранный (M) дельта-варианта имеют большое количество сходств (гомологичных соответствий) с перечисленными белками, причем наибольшее количество — в случае мутации S:Δ156,157;R158G. Причина, по которой дельтавариант SARS CoV-2 обладает специфическими характеристиками, и прежде всего повышенной летальностью, скорее всего, кроется в мутации в положениях 156–158 шипового белка.
The capacity of SARS CoV-2 for immune evasion can be considered universally recognized. Coronavirus and human protein homology may be one of the mechanisms of immune evasion. Delta variant necessarily has structural features that explain its specific qualities. The aim of our study is to find out whether mutations in the structural proteins of Delta variant change its homology with proteins present in the human body, i.e. human, bacterial and dietary. Using bioinformatics tools we detected homology on the heptamer level between Delta variant structural proteins and human proteins as well as some opportunistic bacteria proteins of the upper respiratory tract, lung and gut. Delta variant spike (S) and membrane (M) proteins have a large number of similarities (homologous correspondences) with the listed proteins, with the S:Δ156,157;R158G mutation having the greatest amount. The reason why SARS CoV-2 Delta variant has specific characteristics, most importantly increased lethality, is most likely to be found in a mutation at positions 156–158 of spike protein.
Pathologic and Molecular Features of Perihilar Cholangiocarcinoma Based on U-P Point Division
Authors: Xiao Ying , Zhang Qijia , Xiang Canhong , Yang Jianghui , Li Bowen , Yin Hongfang 
Published: August 2024

Context.—
The Japanese Society of Hepato-Biliary-Pancreatic Surgery guidelines propose a classification scheme that differs from the Union for International Cancer Control (UICC) system, in which the anatomic U-P point is the boundary between intrahepatic cholangiocarcinoma and perihilar cholangiocarcinoma (PCC).

Objective.—
To investigate whether this classification system improves clinicopathologic and genomic differentiation.

Design.—
Fifty-eight PCC cases defined by the UICC system were collected and classified into intrahepatic PCC (IPCC) and extrahepatic PCC (EPCC) categories using U-P point division. They were analyzed by next-generation sequencing using a panel that targeted 425 cancer-related genes.

Results.—
The IPCC group exhibited a significant larger tumor size compared with the EPCC group (4.67 ± 2.44 cm versus 2.50 ± 0.91 cm, P = .002). The mutation frequency of KRAS proto-oncogene, GTPase (KRAS) Q61 was also significantly higher in the IPCC group than in the EPCC group (16.7% versus 0.0%, P = .03). There were no statistically significant differences in other pathologic features or genomic characteristics, including tumor mutation burden and microsatellite instability. Significant differences in gene mutation rates, such as phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA; 0.0% versus 15.8%, P = .01) and tumor protein p53 (TP53; 34.5% versus 63.2%, P = .04), were observed between PCC and adjacent biliary tract cancers.

Conclusions.—
This study offers valuable insight into the clinicopathologic and genomic features of PCC. It is proposed that the U-P point division may have limited potential to refine the characterization of PCC regarding these features, and that the UICC classification system can readily demonstrate the molecular specificity of PCC.
Design of Horizontal Type Mangosteen Peel Flour Machine for Mangosteen Peel Processing
Authors: Ridho Rosyid 
Published: August 2024

The Mangosteen fruit (garcinia mangostana L.) nicknamed the queen of fruit is one of Indonesia's superior fruits. Mangosteen fruit consists of components in the form of seeds, fruit, pulp, and fruit skin. This research aims to design a horizontal-type mangosteen peel-blowing machine. This mangosteen rind flouring machine is designed in a horizontal shape which aims to flour the dried mangosteen rind. The design process uses the Solid Work application and then the manufacturing process. Machines that have been manufactured are subjected to testing. The flouring process uses a separating cylinder and a crushing knife. Dried mangosteen skin that is put into the hopper will enter the cylinder and be crushed by a rotating blade and produce flour. The flour will come out through the output door. This machine floured the skin of the mangosteen fruit according to the initial design objectives. This research succeeded in removing the dried mangosteen peel.
ASSOCIAÇÃO ENTRE A PRÁTICA DE DANÇA E OS NÍVEIS DE ANSIEDADE E ESTRESSE EM JOVENS UNIVERSITÁRIOS
Authors: Ferreira Maria Vaneska Lima , Santos Bárbara Raquel Souza , Vieira Júlia Ramos , Pinheiro Jenifer Kelly 
Published: August 2024

Introdução: A adolescência é a fase em que tomadas de decisões se faz necessária, tornando-se uma transição de risco, pois os jovens podem acabar comprometendo a sua saúde física e mental. Ao entrar na universidade os alunos acabam seguindo uma rotina de grandes desafios e desgastes, podendo gerar depressão, estresse e ansiedade. Objetivo: Sendo assim o estudo teve como objetivo associar a prática de dança aos níveis de ansiedade e estresse em jovens universitários. Método: A pesquisa trata-se de um estudo de campo com abordagem quantitativo, acontecendo em uma universidade localizada na cidade de Juazeiro do Norte-CE. Utilizou-se a Escala de Ansiedade, Depressão e Estresse EADS-21. A análises dos dados foram realizadas por meio do programa software JAMOVI versão 1.6, o teste Shapiro Wilk e o teste qui-quadrado. Participaram 22 jovens do sexo feminino, entre 17 e 27 anos, dos cursos de Enfermagem, Odontologia, Direito, Fisioterapia, Med. Veterinário e Psicológico, dividido entre as que praticavam dança e as que eram sedentárias. Resultados: As participantes que praticavam dança tiveram um menor nível de estresse, depressão e ansiedade, encontra partida as pessoas sedentárias tiveram uma porcentagem de 50% em estresse leve, 50% em estresse moderado, 100% de depressão moderada, 66,7% em ansiedade moderada e 33,3% em ansiedade grave. Conclusão: Conclui-se que a dança é sim uma atividade aeróbica de suma importância para a diminuição do estresse, ansiedade e depressão.
AVALIAÇÃO DA PERCEPÇÃO AMBIENTAL DA COMUNIDADE VILA DO RIO ARIAÚ, MUNICÍPIO DE IRANDUBA, AMAZONAS, BRASIL
Authors: Botinelly Luana , Lubich Chiara , McComb Gisellen , Leite Rubim Maria Anete 
Published: August 2024

A expansão da área urbana é ocasionada pelo grande crescimento demográfico que a cidade vem enfrentando nas duas últimas décadas. Essa concentração urbana tem feito profundas alterações na paisagem, decorrentes das transformações na forma de uso e ocupação do solo. Portanto, o estudo da percepção ambiental é fundamental para compreender as inter-relações entre o homem e o ambiente em que vive. Dessa forma, o objetivo geral desse trabalho foi descrever a percepção ambiental dos moradores da Vila do Rio Ariaú, cuja área de ocupação encontra-se no entorno da floresta e às margens do corpo hídrico, localizada na região metropolitana de Manaus, Amazonas. O estudo ocorreu junto aos moradores da Vila localizada às margens do Rio Ariaú. A coleta de dados foi realizada por meio da aplicação de um questionário semiestruturado e analisados por meio de análise descrita. durante dois dias. Foram entrevistadas 27 pessoas, sendo 17 homens e 10 mulheres, com idade variando entre 19 a 71 anos (43,48 ± 14,18). A maioria dos entrevistados apresentou ensino médio. O poço é a principal fonte de abastecimento da vila, sendo a água tratada com hipoclorito de sódio. A maioria dos entrevistados informou conhecer os riscos de utilizar a água do rio sem tratamento para consumo e recolher o lixo ao verem descartados nos rios. Além disso, se mantem atualizados sobre conservação ambiental por meio da internet. As ações de educação ambiental com essas comunidades são importantes, pois possuem contato direto com o recurso hídrico, logo podendo agir como fiscalizadores do recurso, prezando pela bom uso e conservação desse ambiente.
Bentuk Aransemen dan Struktur Aransemen Lagu Seblang Subuh Karya Budi Susanto Yohanes Untuk Paduan Suara
Authors: Qurroti A'yunin Dinda , Senyum Sadhana  
Published: August 2024

Penelitian ini bertujuan untuk mengetahui bentuk aransemen dan struktur aransemen lagu Seblang Subuh yang menjadi ikon dalam diri Budi Susanto Yohanes setiap mengaransemen lagu folklore atau lagu rakyat. Metode yang digunakan dalam penelitian ini adalah jenis penelitian kualitatif. Sumber data diperoleh dari beberapa data yang dipaparkan oleh narasumber, yaitu narasumber primer dan sekunder. Teknik pengumpulan data dilakukan dengan observasi, wawancara, dan dokumentasi. Validitas data dilakukan dengan teknik triangulasi atau penggabungan dan membandingkan hasil data yang diperoleh. Teknik analisis data melalui tahapan reduksi data, penyajian data, dan kesimpulan. Berdasarkan hasil penelitian yang diperoleh bentuk aransemen lagu Seblang Subuh karya Budi Susanto Yohanes untuk paduan suara, salah satu tim paduan suara yang menjadi objek yaitu Gita Pramawisesa. Pada pembahasan yaitu bentuk lagu menggunakan teori Karl-Edmund (1996:5) menyatakan bahwa bentuk dapat dilihat secara pra.ktis sebagai “wadah” yang “diisi” oleh seorang kom.ponis dan diolah sedemikian rupa hingga men.jadi musik yang hidup. sedangkan pada aransemen menggunakan teori Genichi yang didalamnya terdapat ornamen aransemen fill in dan filler disini yang diteliti hanya fill in. dalam bentuk lagu terdapat struktur lagu meliputi pada teori Kawakami (1975:260) terdapat elemen yang membentuk struktur aransemen yaitu introduksi, chorus (inti lagu), Bridge, variasi, coda.
DETERMINATION OF ANTIOXIDANT ACTIVITY OF SALAK PONDOH (Salacca zalacca Gaertnes Voss) SKIN USING DPPH (2,2-diphenyl-1-picrylhydrazyl) METHOD AS ACTIVE INGREDIENT OF FACE MASK PRODUCT
Authors: Rusdi Moh 
Published: August 2024

Based on the results of phytochemical tests, salak pondoh skin (Salacca zalacca Gaertnes Voss) contains alkaloid, flavonoid, and saponin compounds. Secondary metabolites such as alkaloids, flavonoids, and saponins show pharmacological effects as antioxidant compounds. Testing secondary metabolites in salak pondoh skin extract is the first step to using salak pondoh skin as an active component in face masks. This study aims to determine the antioxidant activity of salak pondoh skin extract using the DPPH (2,2-difenil-1-pikrilhidrazil) method and its application as an active ingredient in face mask formulations. Antioxidant activity test of salak skin ethanol extract using DPPH method by determining IC50 value. From the test results, the IC50 antioxidant activity was 51.498 mg/L. This means that salak skin has strong antioxidant activity to capture free radicals
The Door Ajar: Adilia Lopes and the Art of Approximation
Authors: Rothenberg Rachel 
Published: August 2024

Abstract: A self-declared “pop-poetess,” Adília Lopes has gained recognition in recent years in both literary and pop-cultural spheres, publishing fifteen books since 1985, contributing constantly to Portuguese periodicals, and making frequent television appearances. Lopes is not only an influential contemporary poet, but a public figure whose pseudonym holds both the weight of her written work and the attributes of the persona that she has created in the public eye. Perhaps it is due to her extreme visibility in the media, her absolute candor—whether in writing poems that address her literary influences or revealing the details of her personal life on the latest permutation of reality television—that she is so often taken at face value. Much of the critical attention afforded her is aimed at her reliance upon satirical allusion, word games, and shock value, as the polemic nature of her poems often outshines their actual intentions. This paper seeks to demonstrate that Lopes should not be taken lightly, that despite the initial response that Lopes’s poems incite, a deliberate, ambitious voice emerges from the body of her work. Within the bounds of her poems, Adília Lopes lucidly defines her relationship to Portuguese and international literary continuities while presenting a meticulously formulated aesthetic in which instances of deferred resolution come to define a process of approximation that holds greater value than any anticipated conclusion.
Estilo e ficção autoral n' "Os Passos em Volta", de Herberto Helder
Authors: Oliveira Sílvia 
Published: August 2024

Resumo: Os Passos em Volta de Herberto Helder, publicado pela primeira vez em 1963, é o único volume de contos numa obra predominantemente poética. Os contos deste volume têm sido sistematicamente interpretados biograficamente (estabelecendo uma unidade de autor textual e empírico); e funcionalmente (cumprindo estes textos em prosa a função de clarificar a poesia de Herberto). Através da releitura de três dos mais citados contos do volume, “Estilo,” “Teoria das Cores,” e “Poeta Obscuro,” discuto que a categoria do narrador nestes textos cria ficções de autor, em vez de reflectir uma entidade extratextual. O princípio estrutural d'Os Passos em Volta é a compulsão para a narrativa. O modo discursivo por excelência destes contos é o irónico. Eu sugiro que estes dois factores inviabilizam as estratégias de leitura monológicas atrás mencionadas.
Сalculations of coverage area when designing a mobile communication network
Authors: Юркин Ю.В. , Маслова А.А. 
Published: August 2024

В статье рассматривается методика расчета максимально допустимых потерь и зоны покрытия в сети наземной подвижной связи. Обосновывается ее применение при проектировании сетей мобильной связи с пакетной коммутацией на железнодорожном транспорте. Для выполнения вычислений на одном из этапов планирования сетей связи стандартов LTE-APro-R и 5G-R предлагается использовать приложение, созданное в среде Visual Studio.
The article deals with the methodology of calculating the maximum allowable losses and coverage area in the land mobile communication network. The article substantiates its use in the design of LTE-APro-R mobile communication network for the needs of railway transportation. To perform calculations at one of the stages of planning the LTE-APro-R and 5G-R communication networks, it is proposed to use an application created in the Visual Studio environment.
Development and Evaluation of a Web-Based Resident Information Management System
Authors: Melendres Uriel M. , Aranda Karlo M. 
Published: August 2024

The development of a Web-Based Resident Information Management System simplifies the process of storing and accessing information of residents compared to the traditional way of information management. Having this kind of system, the barangay could easily perform its duty to the public like planning and implementing different programs and granting other document requests like residence certificates and permits. The Rapid Application Development (RAD) model was utilized as a system development method since it emphasizes the quick design development cycle and high-quality outcomes. The system was undergone testing and evaluation using six ISO 25010 criteria. An average mean result of 3.48 for functional suitability, 3.62 for performance efficiency, 3.58 for compatibility, 3.42 for usability, 3.44 for reliability, and 3.51 for security shows that the developed system met the user requirements and is ready for implementation. This will make it easier for the barangay to maintain residents’ records and provide hassle-free services.
Entrevista com Francisco Rezek, ex-ministro do Supremo Tribunal Federal
Authors: Rezek Francisco , Morato de Andrade Otávio , Duarte Francis 
Published: August 2024

Francisco Rezek nasceu em Cristina, no sul de Minas Gerais, a 18 de janeiro de 1944, numa família originária da província de Baalbek, no Líbano. Graduou-se pela Faculdade de Direito da UFMG (FDUFMG), tendo sido o orador da turma de 1966, e obteve o doutoramento pela Sorbonne, Paris, em 1970. Foi professor da FDUFMG, da Universidade de Brasília e do Instituto Rio Branco. Procurador da República do primeiro concurso, em 1972, era já Subprocurador-Geral quando foi nomeado ministro do Supremo Tribunal Federal (STF) em 1983, aos 39 anos de idade. Em 1990, pediu exoneração da magistratura para assumir o Ministério das Relações Exteriores, voltando a ser indicado para o STF em 1992. Até hoje, foi o único ministro com dois ingressos na Suprema Corte. Após a aposentadoria do STF, em 1997, foi eleito pelas Nações Unidas para um mandato de juiz da Corte Internacional de Justiça, permanecendo na Haia até 2006. Desde seu retorno atua na advocacia consultiva em São Paulo. Nesta entrevista, Rezek rememora seus tempos na Vetusta, destaca marcos de sua notável trajetória como servidor público e compartilha reflexões sobre direito e justiça no Brasil e no mundo.
Determination of Polyphenols, Reducing Potential and FT-IR Analysis of Green Tea (Camellia sinensis L.) Leaves Extract for Nanoparticles Synthesis
Authors: Bisht Komal , Pandey Niharika , Gautam Sneh , Lohani Pushpa 
Published: August 2024

Green Tea (Camellia sinensis L.) is renowned for its therapeutic properties due to its phenolic compounds. Extracts from plants with high polyphenol content possess antioxidant properties that neutralize free radicals involved in the oxidation of various molecules. This study investigated the total phenolic and flavonoid content, 1,1-diphenylpicrylhydrazyl (DPPH) radical scavenging activity (RSA), and ferric reducing antioxidant power (FRAP) of commercially available green tea leaves for potential use in the green synthesis of silica nanoparticles. The antioxidant activity of green tea leaves demonstrates its reducing power, which is crucial for utilizing its extract in nanoparticle synthesis. Gallic acid and quercetin served as standards in the Folin–Ciocalteu and aluminum chloride methods, respectively, to measure total phenolic and flavonoid concentrations. To determine antioxidant content ascorbic acid and gallic acid were standards for the DPPH free radical scavenging and FRAP assays. Fourier Transform Infrared (FT-IR) spectra was performed to evaluate the green tea extract. The results revealed green tea leaves exhibited high phenolic, flavonoid content and significant antioxidant activity. The presence of few notable vibrational bands in FT-IR graph also confirmed the existence of chemical substances that are associated with antioxidant qualities (polyphenols, flavonoids). Indicating that the green tea leaf extract can act as an effective reducing and capping agent in the synthesis of silica nanoparticles.