bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics and early treatment outcomes of follicular lymphoma in young adults
Authors: Gangatharan Shane A. , Maganti Manjula , Kuruvilla John G. , Kukreti Vishal , Tiedemann Rodger E. , Gospodarowicz Mary K. , Hodgson David C. , Sun Alex , Tsang Richard W. , Pintilie Melania , Crump Michael 
Published: April 2015

SummaryFollicular lymphoma (FL) in young adults (YA, <40 years old) is uncommon, and the clinical characteristics and outcomes of this group are not well defined. We conducted a retrospective database review of 427 patients with newly diagnosed FL aged 65 years or less registered at Princess Margaret Cancer Centre between 1995 and 2010. YA (n = 61) and those 40–65 (n = 366) were compared with regards to clinical stage at diagnosis, FL International Prognostic Index (FLIPI) score, and the following clinical outcomes: time to second treatment, cause‐specific survival (CSS) and overall survival (OS). At diagnosis, stage and FLIPI score were similar, as were the proportion of patients requiring therapy (YA 75% versus older adults 71%). Median follow‐up was 8·1 years. Time to second therapy was similar in both age groups (5‐year probability 23% YA versus 27% older adults; Gray's P‐value = 0·76). Ten‐year OS was significantly higher for YA (87% versus older adults 72%; P = 0·029). On multivariate analysis, age <40 years, low FLIPI score and observation as initial management were favourable prognostic factors for OS and CSS. We conclude that YA with FL have a favourable prognosis compared to older patients; whether this reflects competing mortality risks or age‐related differences in lymphoma biology warrants further investigation.
Phase I study of OPB‐51602, an oral inhibitor of signal transducer and activator of transcription 3, in patients with relapsed/refractory hematological malignancies
Authors: Ogura Michinori , Uchida Toshiki , Terui Yasuhito , Hayakawa Fumihiko , Kobayashi Yukio , Taniwaki Masafumi , Takamatsu Yasushi , Naoe Tomoki , Tobinai Kensei , Munakata Wataru , Yamauchi Takeshi , Kageyama Akiko , Yuasa Miyuki , Motoyama Masaaki , Tsunoda Takeshi , Hatake Kiyohiko 
Published: April 2015

We carried out a multicenter dose‐escalation phase I study of oral OPB‐51602, a signal transducer and activator of transcription 3 phosphorylation inhibitor, in patients with relapsed or refractory hematological malignancies to evaluate the safety, maximum tolerated dose (MTD), pharmacokinetics, and preliminary antitumor activity. Twenty patients were treated with OPB‐51602 at doses of 1, 2, 3, 4, and 6 mg in the “3 + 3” dose escalation design. The most common treatment‐related adverse events included nausea (55%), peripheral sensory neuropathy (45%), and diarrhea (40%). The most frequently observed grade 3 or 4 drug‐related adverse events were neutropenia (20%), leukopenia (15%), lymphopenia (10%), and thrombocytopenia (10%). The MTD was 6 mg, with dose‐limiting toxicities of grade 3 lactic acidosis and increased blood lactic acid levels observed in one of three patients and grade 1–2 peripheral neuropathy in three of three patients. The recommended dose was determined to be 4 mg. OPB‐51602 was rapidly absorbed, and exposure tended to increase in a dose‐dependent manner. Accumulation of OPB‐51602 was seen with 4 weeks of multiple treatments. No clear therapeutic response was observed. Durable stable disease was observed in two patients with acute myeloid leukemia and one with myeloma. In conclusion, the MTD of OPB‐51602 was 6 mg. OPB‐51602 was safe and well tolerated in a dose range of 1–4 mg. However, long‐term administration at higher doses was difficult with the daily dosing schedule, and no response was seen. Therefore, further clinical development of OPB‐51602 for hematological malignancies with a daily dosing schedule was terminated.
Individual Differences in Environmental Sensitivity
Authors: Pluess Michael 
Published: April 2015

AbstractA fundamental trait found in most organisms is the ability to register, process, and respond to external factors. Although such environmental sensitivity is critical for adapting successfully to contextual conditions, individuals tend to differ in their sensitivity to the environment, with some more sensitive than others. Such differences in environmental sensitivity can be seen across many species, including humans. Although the notion of variability in environmental sensitivity is reflected indirectly in many traditional concepts of human psychology, several new frameworks address individual differences in environmental sensitivity more directly and from a perspective of developmental and evolutionary theory. In this article, I integrate these perspectives into a broad meta‐framework before proposing ideas for research on individual differences in environmental sensitivity. I also emphasize that inter‐individual variability in environmental sensitivity be considered in both theoretical and applied work.
Bidirectionality in Self‐Regulation and Expressive Vocabulary: Comparisons Between Monolingual and Dual Language Learners in Preschool
Authors: Bohlmann Natalie L. , Maier Michelle F. , Palacios Natalia 
Published: April 2015

Significant differences in language and self‐regulation skills exist among children when they enter formal schooling. Contributing to these language differences is a growing population of dual language learners (DLLs) in the United States. Given evidence linking self‐regulatory processes and language development, this study explored bidirectional associations between English expressive vocabulary and self‐regulation skills for monolingual English and DLL preschool children (N = 250) from mixed‐income families in Los Angeles. Across three time points, findings provide initial support for bidirectionality between these developing skills for both monolinguals and DLLs. Results provide strong empirical support for vocabulary serving as a leading indicator of self‐regulation skills in preschool. Findings also suggest that early self‐regulation skills play a particularly important role for vocabulary development.
Targeted IgA Fc receptor I (FcαRI) therapy in the early intervention and treatment of pristane-induced lupus nephritis in mice
Authors: Liu C , Kanamaru Y , Watanabe T , Tada N , Horikoshi S , Suzuki Y , Liu Z , Tomino Y 
Published: April 2015

Summary
The Fc receptor I for IgA (FcαRI) down-regulates humoral immune responses and modulates the risk of autoimmunity. This study aimed to investigate whether FcαRI targeting can affect progression of pristine-induced lupus nephritis. In the first experiment (early intervention), four groups of animals were evaluated: untreated FcαRI/FcRγ transgenic (Tg) mice and Tg mice administered control antibody (Ctr Fab), saline and anti-FcαRI Fab [macrophage inflammatory protein (MIP)-8a], respectively, three times a week for 29 weeks, after being injected once intraperitoneally with 0·5 ml pristane. In the second experiment, antibody injection started after the onset of nephritis and was carried out for 2 months, with similar groups as described above. MIP-8a improved proteinuria, decreased the amounts of glomerular injury markers, serum interleukin (IL)-6, IL-1 and monocyte chemoattractant protein (MCP)-1, and F4/80 macrophages in the interstitium and glomeruli, in both experiments. When MIP-8a was used as early intervention, a decrease in mouse serum anti-nuclear antibody (ANA) titres and reduced deposition of immunoglobulins in glomeruli were observed. This effect was associated with reduced serum titres of immunoglobulin (Ig)G2a but not IgG1, IgG2b and IgG3. Furthermore, pathological analysis showed lower glomerular activity index and less fibronectin in MIP-8a treated mice. This study suggests that FcαRI targeting could halt disease progression and lupus activation by selective inhibition of cytokine production, leucocyte recruitment and renal inflammation. Our findings provide a basis for the use of FcαRI as a molecular target for the treatment of lupus.
A fully digital approach to replicate peri‐implant soft tissue contours and emergence profile in the esthetic zone
Authors: Monaco Carlo , Evangelisti Edoardo , Scotti Roberto , Mignani Giuseppe , Zucchelli Giovanni 
Published: April 2015

AbstractObjectiveThis short communication reports on a novel digital technique designated – the “Fully Digital Technique (FDT)” – to take the impression of the peri‐implant soft tissue and emergence profile with an intraoral scanner, digitally capturing both the three dimensional position of the implant platform and the coronal and gingival parts of the provisional retained restoration.Materials and methodsA first intraoral digital impression, which generated a standard triangulation language file (STL1), was taken using a standardized implant scanbody to detect the position of the implant. A second digital impression (STL2) with the provisional retained restoration in situ was performed in two steps: the first part of the scan captured all details of the vestibular and palatal sides of the provisional retained restoration and the adjacent teeth. The provisional retained restoration was then unscrewed, and the subgingival part of the restoration was scanned directly out of the mouth to determine its subgingival shape. STL1 and STL2 were imported into imaging software and superimposed using the “best fit” algorithm to achieve a new merged file (STL3) with the 3D implant position, the peri‐implant mucosa, and emergence profile. The merged file was used to design the CAD/CAM customized abutment and to realize a stereolithographic model by 3D printing.ResultsThe STL superimposition of digital impressions of the implant position and the provisional retained restoration constitute a novel technique to obtain a single STL file with the implant position and its peri‐implant mucosal architecture.ConclusionsFDT is a rapid digital approach for achieving all information of the peri‐implant soft tissue and emergence profile directly from the provisional retained restoration.
Histomorphologic spectrum of BAP1 negative melanocytic neoplasms in a family with BAP1‐associated cancer susceptibility syndrome
Authors: Marušić Zlatko , Buljan Marija , Busam Klaus J. 
Published: April 2015

BackgroundMultiple BAP1 negative melanocytic neoplasms are a hallmark of familial cancer susceptibility syndrome caused by BAP1 germline mutation. The syndrome is characterized by increased incidence of renal cell carcinoma, mesothelioma, cholangiocarcinoma, cutaneous and uveal melanoma and some other neoplasms.MethodsWe report histomorphologic characteristics of six cutaneous melanocytic neoplasms with loss of BAP1 expression in two members of a family with BAP1‐associated cancer susceptibility syndrome.ResultsThe neoplasms were dermal melanocytic nevi characterized by a proliferation of large epithelioid (spitzoid) melanocytes, and adipocytic metaplasia. Nuclear pseudoinclusions and multinucleated melanocytes were present in most neoplasms. In two of the cases, a nodular melanoma was found associated with a dermal nevus. None of the melanomas recurred or metastasized after 6 and 3 years of follow up.ConclusionsWe report two new cases of melanoma arising in a BAP1‐deficient melanocytic nevus in the setting of familial tumor predisposition syndrome. Adipocytic metaplasia and nuclear pseudoinclusions may be additional morphologic clues to a BAP1‐deficient nevus. It remains to be seen whether these features are more common in familial than sporadic lesions.
Safety and efficacy of once‐weekly dulaglutide versus sitagliptin after 2 years in metformin‐treated patients with type 2 diabetes (AWARD‐5): a randomized, phase III study
Authors: Weinstock R. S. , Guerci B. , Umpierrez G. , Nauck M. A. , Skrivanek Z. , Milicevic Z. 
Published: April 2015

AimsTo compare the once‐weekly glucagon‐like peptide‐1 (GLP‐1) receptor dulaglutide with the dipeptidyl peptidase‐4 (DPP‐4) inhibitor sitagliptin after 104 weeks of treatment.MethodsThis AWARD‐5 study was a multicentre, double‐blind trial that randomized participants to dulaglutide (1.5 or 0.75 mg) or sitagliptin 100 mg for 104 weeks or placebo (reported separately) for 26 weeks. Change in glycated haemoglobin (HbA1c) concentration from baseline was the primary efficacy measure. A total of 1098 participants with HbA1c concentrations ≥7.0% (≥53.0 mmol/mol) and ≤9.5% (≤80.3 mmol/mol) were randomized, and 657 (59.8%) completed the study. We report results for dulaglutide and sitagliptin at the final endpoint.ResultsChanges in HbA1c at 104 weeks were (least squares mean ± standard error) −0.99 ± 0.06% (−10.82 ± 0.66 mmol/mol), −0.71 ± 0.07% (−7.76 ± 0.77 mmol/mol) and −0.32 ± 0.06% (−3.50 ± 0.66 mmol/mol) for dulaglutide 1.5 mg, dulaglutide 0.75 mg and sitagliptin, respectively (p < 0.001, both dulaglutide doses vs sitagliptin). Weight loss was greater with dulaglutide 1.5 mg (p < 0.001) and similar with 0.75 mg versus sitagliptin (2.88 ± 0.25, 2.39 ± 0.26 and 1.75 ± 0.25 kg, respectively). Gastrointestinal adverse events were more common with dulaglutide 1.5 and 0.75 mg versus sitagliptin (nausea 17 and 15% vs 7%, diarrhoea 16 and 12% vs 6%, vomiting 14 and 8% vs 4% respectively). Pancreatic, thyroid, cardiovascular and hypersensitivity safety were similar across groups.ConclusionsDulaglutide doses provided superior glycaemic control and dulaglutide 1.5 mg resulted in greater weight reduction versus sitagliptin at 104 weeks, with acceptable safety.
Validation of the composite autonomic symptom scale 31 (COMPASS‐31) in patients with and without small fiber polyneuropathy
Authors: Treister R. , O'Neil K. , Downs H. M. , Oaklander A. L. 
Published: April 2015

Background and purposeThe recently developed composite autonomic symptom score 31 (COMPASS‐31) is a questionnaire that assess symptoms of dysautonomia. It was distilled from the well‐established Autonomic Symptom Profile questionnaire. COMPASS‐31 has not yet been externally validated. To do so, its psychometric properties and convergent validity in patients with and without objective diagnosis of small fiber polyneuropathy (SFPN) were assessed.MethodsInternal validity and reliability of COMPASS‐31 were assessed in participants with or without SFPN spanning the full range of severity of autonomic symptoms. Convergent validity was assessed by comparing results of the COMPASS‐31 with the “gold standard” autonomic function testing that measures cardiovagal, adrenergic and sudomotor functions. Additionally, relationships between COMPASS‐31 and the Short Form McGill Pain Questionnaire, Short Form Health Survey and 0–10 numeric pain scale were measured. COMPASS‐31 and all other questionnaire results were compared between patients with or without evidence of SFPN, objectively confirmed by distal‐leg PGP9.5‐immunolabeled skin biopsy.ResultsAmongst 66 participants (28 SFPN+, 38 SFPN−), COMPASS‐31 total scores had excellent internal validity (Cronbach's α = 0.919), test–retest reliability (rs = 0.886; P < 0.001) and good convergent validity (rs = 0.474; P < 0.001). COMPASS‐31 scores differed between subjects with or without SFPN (Z = −3.296, P < 0.001) and demonstrated fair diagnostic accuracy. Area under the Receiver Operating Characteristic curve was 0.749 (P = 0.01, 95% confidence interval 0.627–0.871).ConclusionsCOMPASS‐31 has good psychometric properties in the population of patients being evaluated for SFPN and thus it might be useful as an initial screening tool for the more expensive SFPN objective tests.
Resilience of mollusc communities of the River Saone (eastern France) and its two main tributaries after the 2003 heatwave
Authors: Mouthon Jacques , Daufresne Martin 
Published: April 2015

Summary

Global climate change can increase the mean and variability of temperature and may increase the occurrence of extremes such as heatwaves. Both gradual and abrupt warming may perturb freshwater communities, but understanding of ecological resilience to such events is limited.

We report the response of mollusc communities in the River Saone and its two main tributaries to the European heatwave of 2003 and determine the extent of community recovery over 8 years following this rare extreme event, during a period of gradual warming.

The 2003 heatwave had a major impact on the density and species richness of mollusc communities across the study area. After the heatwave, abiotic conditions favoured recolonisation by molluscs, yet full recovery of community states (defined as the combination of structure × density × species richness) was not observed at any site.

Given the profound changes observed in the mollusc community structure in the Saone River and in its two main tributaries and the observed slow pace of recovery relative to that observed elsewhere for pulse disturbances (typically < 3 years), we suggest that global change, including warming, may preclude community recovery from pulse disturbances, such as extreme events, and instead yield communities comprising new combinations of species.
Spatial variation in periphyton fatty acid composition in subtropical streams
Authors: Guo Fen , Kainz Martin J. , Sheldon Fran , Bunn Stuart E. 
Published: April 2015

SummaryBenthic algae play an important role in many stream food webs, not only serving as a major carbon source but also influencing energy transfer as the primary source of polyunsaturated fatty acids (PUFA). Dietary deficiency inPUFAcan limit animal growth and reproduction. AlgalPUFAcontent can vary considerably in response to abiotic factors.We conducted a field investigation in streams in South‐East Queensland, Australia, to identify environmental factors affecting the fatty acid composition of periphyton.Riparian canopy cover andNOx‐Nconcentrations explained most of the observed variation in periphyton fatty acid profiles.NOx‐Nconcentrations showed negative relationships with most saturated fatty acids (SAFA), while mono‐unsaturated fatty acids (MUFA) and the fatty acids 16:0 and 16:1ω7 were negatively correlated with canopy cover. In contrast, the percentage of highly unsaturated fatty acids (HUFA) in periphyton was greater with increasing canopy cover regardless ofNOx‐Nconcentrations.Variation in riparian canopy cover and nutrients gave rise to opposite outcomes in terms of periphyton food quality and quantity. The highest periphyton food quality, measured byHUFAcontent, occurred in streams with high canopy cover and low nutrients, while the highest periphyton food quantity occurred in streams with low canopy cover.Our study suggests that changes in riparian vegetation and/or nutrient inputs can significantly alter the fatty acid content of periphyton, with important implications for aquatic consumers. We recommend that future studies on impacts of riparian clearing or nutrient enrichment in stream ecosystems place more attention on the effects of food quality rather than quantity.
Are Depressive Symptomatology, Self‐Efficacy, and Perceived Social Support Related to Disability and Quality of Life in Patients With Chronic Migraine Associated to Medication Overuse? Data From a Cross‐Sectional Study
Authors: D'Amico Domenico , Grazzi Licia , Bussone Gennaro , Curone Marcella , Di Fiore Paola , Usai Susanna , Leonardi Matilde , Giovannetti Ambra Mara , Schiavolin Silvia , Raggi Alberto 
Published: April 2015

BackgroundChronic migraine with medication overuse (CM‐MO) impairs quality of life (QoL) and causes disability. Psychosocial variables such as depressive symptomatology, self‐efficacy, and social support have been sparingly investigated, and their impact on disability and QoL is unknown.MethodsPatients with CM‐MO under withdrawal were consecutively enrolled. Standardized measures of disability and QoL were used as outcomes; psychosocial (ie, mood state, self‐efficacy, social support) and clinical (ie, headache frequency and intensity) variables were considered as associated variables. Associations between these variables, disability, and QoL were tested with Pearson's correlations. Hierarchical multiple regression was used to assess the cumulative contribution of psychosocial variables on disability and QoL variation when added to clinical variables.ResultsOne hundred ninety‐four patients were enrolled; 82.5% were females and mean age was 43.9. Disability and QoL were moderately or little correlated to clinical and psychosocial variables. Models based on clinical variables explained 7.5‐14.3% of disability and QoL variation, with pain intensity being the only significant predictor; when psychosocial variables were added, the explained variation increased to 21.5‐35.2%, with depressive symptomatology always having independent predictive power and perceived social support having independent predictive power in the regression model over role‐prevention component of QoL.ConclusionsAdding information on psychosocial variables to headache features improved our ability to understand disability and QoL of CM‐MO patients. We deem that the inclusion of psychosocial variables in standard evaluation protocols may contribute to the global assessment of CM‐MO patients, and eventually to their success in reducing the personal and social impact of this condition. Future longitudinal studies are needed to confirm this hypothesis.
The expression of astrocyte elevated gene‐1 in human non‐small‐cell lung cancer and its relationship with postoperative chemotherapy and radiotherapy
Authors: Lu Shan , Xu Jianyu , Xu Xiangying , Hu Songliu , Li Bin , Li Wenxin 
Published: April 2015

AimsTo examine the expression of astrocyte elevated gene‐1 (AEG‐1) in non‐small‐cell lung cancer (NSCLC) and analyse the correlation between AEG‐1 expression and the prognosis of the patients, particularly the relationship between AEG‐1 expression and postoperative chemotherapy and radiotherapy.MethodsThe expression of AEG‐1 was analysed by immunohistochemistry in 225 primary NSCLC specimens and 42 adjacent normal lung tissue specimens. Statistical analyses were performed to evaluate the correlation between AEG‐1 expression and the clinicopathological characteristics of the patients as well as the predictive value of AEG‐1.ResultsThe expression of AEG‐1 was associated with the pathological stage (P < 0.001) and lymph node status (P = 0.028). A multivariate analysis indicated that AEG‐1 expression was an independent prognostic factor for both overall survival (OS) and disease‐free survival (DFS). In the postoperative chemotherapy group, the OS (P = 0.014) and DFS (P = 0.009) in the low AEG‐1 expression group were longer than the survival times in the high AEG‐1 expression group. In the postoperative radiotherapy group, the local recurrence‐free survival was significantly shorter in patients whose tumours showed high AEG‐1 expression (P = 0.016).ConclusionsAEG‐1 expression could be a predictor for OS and DFS in NSCLC patients. Patients with low AEG‐1 expression received the greatest benefit from both postoperative chemotherapy and radiotherapy.