bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trunk and Hip Biomechanics Influence Anterior Cruciate Loading Mechanisms in Physically Active Participants
Authors: Frank Barnett , Bell David R. , Norcross Marc F. , Blackburn J. Troy , Goerger Benjamin M. , Padua Darin A. 
Published: July 2013

Background: Excessive trunk motion and deficits in neuromuscular control (NMC) of the lumbopelvic hip complex are risk factors for anterior cruciate ligament (ACL) injury. However, the relationship between trunk motion, NMC of the lumbopelvic hip complex, and triplanar knee loads during a sidestep cutting task has not been examined. Purpose: To determine if there is an association between multiplanar trunk motion, NMC of the lumbopelvic hip complex, and triplanar knee loads with ACL injury during a sidestep cutting task. Study Design: Descriptive laboratory study. Methods: The hip and knee biomechanics and trunk motion of 30 participants (15 male, 15 female) were analyzed during a sidestep cutting task using an optoelectric camera system interfaced to a force plate. Trunk and lower extremity biomechanics were calculated from the kinematic and ground-reaction force data during the first 50% of the stance time during the cutting task. Pearson product moment correlation coefficients were calculated between trunk and lower extremity biomechanics. Multiple linear regression analyses were carried out to determine the amount of variance in triplanar knee loading explained by trunk motion and hip moments. Results: A greater internal knee varus moment (mean, 0.11 ± 0.12 N·m/kg*m) was associated with less transverse-plane trunk rotation away from the stance limb (mean, 20.25° ± 4.42°; r = −0.46, P = .011) and a greater internal hip adduction moment (mean, 0.33 ± 0.25 N·m/kg*m; r = 0.83, P < .05). A greater internal knee external rotation moment (mean, 0.11 ± 0.08 N·m/kg*m) was associated with a greater forward trunk flexion (mean, 7.62° ± 5.28°; r = 0.42, P = .020) and a greater hip internal rotation moment (mean, 0.15 ± 0.16 N·m/kg*m; r = 0.59, P = .001). Trunk rotation and hip adduction moment explained 81% ( P < .05) of the variance in knee varus moment. Trunk flexion and hip internal rotation moment explained 48% ( P < .05) of the variance in knee external rotation moment. Conclusion: Limited trunk rotation displacement toward the new direction of travel and hip adduction moment are associated with an increased internal knee varus moment, while a combined increase in trunk flexion displacement and hip internal rotation moment is associated with a higher internal knee external rotation moment. Clinical Relevance: Prevention interventions for ACL injury should encourage trunk rotation toward the new direction of travel and limit excessive trunk flexion while adjusting frontal- and transverse-plane hip NMC.
Green Coffee for Pharmacological Weight Loss
Authors: Buchanan Rachel , Beckett Robert D. 
Published: July 2013

This review article evaluates if clinical data support the use of green coffee for weight loss. A literature search was conducted that yielded 5 clinical trials and 1 meta-analysis. Studies were evaluated for quality in accordance to clinical practice and US Food and Drug Administration guidelines. The amount of weight loss ranged from approximately 1 to 8 kg, with the meta-analysis finding a statistically significant difference in body weight, with a mean difference of −2.47 kg between green coffee and placebo (95% confidence interval = −4.23 to −0.72). The duration of trials varied between 4 and 12 weeks, and the dose of chlorogenic acid varied from 81 to 400 mg. Few published studies were in compliance with the US Food and Drug Administration guidelines. Despite the potentially clinically significant weight loss achieved in some published studies, all held significant limitations. Green coffee extract is not recommended as a safe or effective treatment for weight loss.
Deflocculant consumption of clay suspensions as a function of specific surface area and cation exchange capacity
Authors: Delavi D. G. G. , De Noni A. , Hotza D. 
Published: July 2013

AbstractCeramic tile production by the wet route requires clay suspensions with a high solid content and low viscosity. In this work the deflocculation of clays in aqueous suspensions was investigated by varying the type of clay and additive. Three kaolinitic and two illitic clays were characterized and dispersed with deflocculants based on lithium, sodium and potassium silicates and polyacrylates. The clays were characterized by chemical and mineralogical analyses, particle size distribution, zeta potential, organic carbon content, cation exchange capacity (CEC) and specific surface area (BET). Deflocculation curves were determined by measuring the viscosity for 50 wt.% clay slips. The results indicate that additive consumption is closely related to CEC and BET, which correspond respectively to the chemical and physical characteristics of the clay mineral's surface. Moreover, viscosity values at the deflocculation point are closely related to BET.
Incorporation of Al in iron oxyhydroxides: implications for the structure of ferrihydrite
Authors: Manceau A. , Gates W.P. 
Published: July 2013

AbstractThe incomplete miscibility of Al into the ferrihydrite structure has been a recurring issue in understanding the environmental geochemistry of this important oxyhydroxide. During co-precipitation from acidic aqueous solution, ferrihydrite has been observed to accept only up to ∼25 at.% Al without the formation of multi-phasic Al and Fe oxyhydroxides. Using basic chemistry and crystal-chemical relationships we propose here that the saturation limit of Al substitution in the structure of Fe oxyhydroxides is controlled by Al – Al avoidance in a manner that conforms to Pauling's distortion rule. Employing this hypothesis, we show that the predicted miscibility limit for Al incorporation is 25 at.% in ferrihydrite and 33 at.% in goethite, in agreement with previous observations. These results indicate that the classical f-phase model for ferrihydrite best represents observations. Incorrect assignment of Fe site occupancy and other shortcomings of the akdalaite/tohdite model for ferrihydrite are also discussed.
Specific gene delivery to liver sinusoidal and artery endothelial cells
Authors: Abel Tobias , El Filali Ebtisam , Waern Johan , Schneider Irene C. , Yuan Qinggong , Münch Robert C. , Hick Meike , Warnecke Gregor , Madrahimov Nodir , Kontermann Roland E. , Schüttrumpf Jörg , Müller Ulrike C. , Seppen Jurgen , Ott Michael , Buchholz Christian J. 
Published: July 2013

Key Points
CD105-mediated cell entry using targeted lentiviral vectors leads to specific gene transfer of LSEC upon systemic administration.
COP1 targets C/EBPα for degradation and induces acute myeloid leukemia via Trib1
Authors: Yoshida Akihiro , Kato Jun-ya , Nakamae Ikuko , Yoneda-Kato Noriko 
Published: July 2013

Key Points
Ectopic COP1 decreases C/EBPα and blocks granulocyte differentiation in 32D cells. Trib1 binds to COP1 to enhance its ubiquitin ligase activity for C/EBPα. COP1 accelerates development of AML induced by Trib1.
Integrated OMICS guided engineering of biofuel butanol-tolerance in photosynthetic Synechocystissp. PCC 6803
Authors: Zhu Hongji , Ren Xiaoyue , Wang Jiangxin , Song Zhongdi , Shi Mengliang , Qiao Jianjun , Tian Xiaoxu , Liu Jie , Chen Lei , Zhang Weiwen 
Published: July 2013

Abstract

Background
Photosynthetic cyanobacteria have been recently proposed as a ‘microbial factory’ to produce butanol due to their capability to utilize solar energy and CO2 as the sole energy and carbon sources, respectively. However, to improve the productivity, one key issue needed to be addressed is the low tolerance of the photosynthetic hosts to butanol.

Results
In this study, we first applied a quantitative transcriptomics approach with a next-generation RNA sequencing technology to identify gene targets relevant to butanol tolerance in a model cyanobacterium Synechocystis sp. PCC 6803. The results showed that 278 genes were induced by the butanol exposure at all three sampling points through the growth time course. Genes encoding heat-shock proteins, oxidative stress related proteins, transporters and proteins involved in common stress responses, were induced by butanol exposure. We then applied GC-MS based metabolomics analysis to determine the metabolic changes associated with the butanol exposure. The results showed that 46 out of 73 chemically classified metabolites were differentially regulated by butanol treatment. Notably, 3-phosphoglycerate, glycine, serine and urea related to general stress responses were elevated in butanol-treated cells. To validate the potential targets, we constructed gene knockout mutants for three selected gene targets. The comparative phenotypic analysis confirmed that these genes were involved in the butanol tolerance.

Conclusion
The integrated OMICS analysis provided a comprehensive view of the complicated molecular mechanisms employed by Synechocystis sp. PCC 6803 against butanol stress, and allowed identification of a series of potential gene candidates for tolerance engineering in cyanobacterium Synechocystis sp. PCC 6803.
The effect of shoe toe box shape and volume on forefoot interdigital and plantar pressures in healthy females
Authors: Branthwaite Helen , Chockalingam Nachiappan , Greenhalgh Andrew 
Published: July 2013

AbstractBackgroundIll‐fitting footwear can be detrimental to foot health with the forefoot being an area for most discomfort. Studies on footwear have primarily examined sports or orthopaedic prescription shoes and little is known about the effects that everyday flat shoes have on the forefoot. The aim of this study was to investigate the effect of toe box shape in a popular slip‐on pump on dorsal and plantar pressures with particular interest around the forefoot in a healthy female population.MethodA convenience sample of 27 female participants with no known foot pathologies was recruited. After assessment of foot size, plantar foot pressure and interdigital pressures were recorded for each of the 3 different toe box styles; round, square and pointed. Participants walked at a self‐selected speed over a 10 m walkway whilst wearing each of the 3 styles of shoe and also whilst barefoot. Processed and analysed data extracted included peak pressure, time to peak pressure, contact time and pressure time integral. ANOVA and Freidman analysis was used to test for statistical significance.ResultsShoes with a round toe showed least pressure around the medial aspect of the toes whilst the pointed shoe had least pressure on the lateral toes. Contact times for the plantar regions were not altered in any shoe condition yet contact around the medial aspect of the toes was highest in the pointed shoe.ConclusionThis study highlights that the shape of the toe box in footwear can significantly influence the amount of pressure applied to the forefoot. Furthermore, the contours of the shoe also have an impact on the contact time and pressure time integral around the forefoot and also the peak plantar pressure in the toe region. The changes observed could be significant in the development of pathology in certain footwear toe box shapes. Consideration should be given to footwear design around the toe box to improve fit and reduce pressure. Further work is required to investigate the effect of toe box shape and volume on a pathological population with pressure related lesions.
Biological activity and microscopic characterization of Lythrum salicaria L
Authors: Manayi Azadeh , Khanavi Mahnaz , Saiednia Soodabeh , Azizi Ebrahim , Reza Mahmoodpour Mohammad , Vafi Fatemeh , Malmir Maryam , Siavashi Farideh , Hadjiakhoondi Abbas 
Published: July 2013

AbstractBackgroundThere are several plants have been used worldwide in the folk medicine with high incidence for treatment of human disorders, of whichLythrum salicariabelongs to the Lythraceae family has traditionally reputation for some medicinal usage and recently many biological and pharmacological activity of the plant have been studied.MethodsIn this study, microscopic characterizations of the aerial parts of the plant were determined. Moreover, the plant extract (aqueous methanol 80%) was subjected to an anti-diabetic activity test (in a rat model of streptozocin induced diabetes), anti-Helicobacter pylori(using disc diffusion method) along with antioxidant activity against DPPH (stable free radical) tests. Besides, total flavonoids, phenols, tannins, as well as polysaccharides contents have been assessed using spectroscopic methods.ResultsThe microscopic properties of the plant fragments revealed anomocytic stomata, conical shape trichomes, and abundant spherical pollen grains as a characteristic pattern for the aerial parts of the plant. The extract of the plant at concentration of 15 g/kg showed mild lowering activity on blood glucose level to 12.6% and 7.3% after 2 and 3 h of administration. Additionally, clinically isolatedH. pyloristrain was inhibited with the plant extract at concentration of 500 mg/mL (zone of inhibition: 17 ± 0.08 mm). Moreover, IC50values for DPPH inhibition of the plant extract, vitamin E, BHA were examined as 13.5, 14.2, and 7.8 μg/mL, respectively. Total flavonoids, phenols, tannin, and polysaccharides contents of the extract were successfully evaluated as 5.8 ± 0.4 μg QE/mg EXT, 331 ± 3.7 μg GAE/mg EXT, 340 ± 2.3 μg TAE/mg EXT, 21 ± 0.2 μg GE/mg EXT, respectively.ConclusionsThe results suggested thatL. salicariahas low anti-diabetic and anti-Helicobacter pylorieffects, but high antioxidant activity, just the same as positive standard (vitamin E), which might be attributed to the high content of phenolic compounds in the extract.
Detecting, quantifying and adjusting for publication bias in meta-analyses: protocol of a systematic review on methods
Authors: Mueller Katharina Felicitas , Meerpohl Joerg J , Briel Matthias , Antes Gerd , Elm Erik von , Lang Britta , Gloy Viktoria , Motschall Edith , Schwarzer Guido , Bassler Dirk 
Published: July 2013

Abstract

Background
Health professionals and policymakers aspire to make healthcare decisions based on the entire relevant research evidence. This, however, can rarely be achieved because a considerable amount of research findings are not published, especially in case of ‘negative’ results - a phenomenon widely recognized as publication bias. Different methods of detecting, quantifying and adjusting for publication bias in meta-analyses have been described in the literature, such as graphical approaches and formal statistical tests to detect publication bias, and statistical approaches to modify effect sizes to adjust a pooled estimate when the presence of publication bias is suspected. An up-to-date systematic review of the existing methods is lacking.

Methods/design
The objectives of this systematic review are as follows:
• To systematically review methodological articles which focus on non-publication of studies and to describe methods of detecting and/or quantifying and/or adjusting for publication bias in meta-analyses.
• To appraise strengths and weaknesses of methods, the resources they require, and the conditions under which the method could be used, based on findings of included studies.
We will systematically search Web of Science, Medline, and the Cochrane Library for methodological articles that describe at least one method of detecting and/or quantifying and/or adjusting for publication bias in meta-analyses. A dedicated data extraction form is developed and pilot-tested. Working in teams of two, we will independently extract relevant information from each eligible article. As this will be a qualitative systematic review, data reporting will involve a descriptive summary.

Discussion
Results are expected to be publicly available in mid 2013. This systematic review together with the results of other systematic reviews of the OPEN project (To Overcome Failure to Publish Negative Findings) will serve as a basis for the development of future policies and guidelines regarding the assessment and handling of publication bias in meta-analyses.
Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils
Authors: Licata Lauren A , Nguyen Cang T , Burga Rachel A , Falanga Vincent , Espat N Joseph , Ayala Alfred , Thorn Mitchell , Junghans Richard P , Katz Steven C 
Published: July 2013

ABSTRACTBiliary obstruction is a common clinical problem that is associated with intrahepatic inflammation and impaired immunity. PD-1 is well known to mediate T cell dysfunction but has been reported to promote and attenuate acute inflammation in various injury models. With the use of a well-established murine model of BDL, we studied the effects of intrahepatic PD-1 expression on LTC function, inflammation, and cholestasis. Following BDL, PD-1 expression increased significantly among LTCs. Increased PD-1 expression following BDL was associated with decreased LTC proliferation and less IFN-γ production. Elimination of PD-1 expression resulted in significantly improved proliferative capacity among LTC following BDL, in addition to a more immunostimulatory cytokine profile. Not only was LTC function rescued in PD-1−/− mice, but also, the degrees of biliary cell injury, cholestasis, and inflammation were diminished significantly compared with WT animals following BDL. PD-1-mediated acute inflammation following BDL was associated with expansions of intrahepatic neutrophil and Th17 cell populations, with the latter dependent on IL-6. PD-1 blockade represents an attractive strategy for reversing intrahepatic immunosuppression while limiting inflammatory liver damage.
Charting the Verbiage of Institutional Vision: Implications for Academic Advising
Authors: Abelman Robert , Dalessandro Amy , Janstova Patricie , Snyder-Suhy Sharon , Pettey Gary 
Published: July 2013

Whether and to what extent a college or university vision is embraced, transformed into action, and dispersed to the campus community by academic advisors is largely dependent on the rhetoric of the vision statement. Through a content analysis of a nation-wide sample of vision and mission statements from NACADA-membership institutions, we isolated key linguistic components that constitute a well-conceived, effective, and easily diffused institutional vision. The prevalence of these components and the types of academic institutions most likely to possess them are discussed. Ways in which this information can be used by advising supervisors to evaluate their own institution's vision and the vision of their advising operation are presented.Relative Emphasis: theory, research, practice
The Advisor as Servant: The Theoretical and Philosophical Relevance of Servant Leadership to Academic Advising
Authors: McClellan Jeffrey L. 
Published: July 2013

In 1979, Robert Greenleaf published Teacher as Servant. This novel actively portrays Greenleaf's concept of servant leadership by describing the extracurricular work of a university professor. Consequently, some scholars have demonstrated the relevance of servant leadership to classroom instruction (Powers & Moore, 2005). However, it was not as an instructor, but as an advisor that the fictional Mr. Billings engaged in servant leadership and deeply transformed his students' lives. By explaining the philosophy and practice of servant leadership, I demonstrate how it can contribute to the theory and practice of academic advising. The characteristics of servant leadership are discussed as a theoretical-philosophical construct relevant to academic advisement.Relative Emphasis: theory, practice, research
The Influence of Graduate Advisor Use of Interpersonal Humor on Graduate Students
Authors: Wrench Jason S. , Punyanunt-Carter Narissra M. 
Published: July 2013

The current study is the fourth in a series on various components of advisor-advisee communication. In the latest study, the influence of a variety of communication variables on the graduate advisor–advisee interpersonal relationship is examined. Graduate students' perceptions of their graduate advisors' use of humor as it relates to other communication variables (nonverbal immediacy, social support, mentoring, and relationship satisfaction) were investigated. Results revealed a positive, statistically significant relationship between an advisee's perception of his or her advisor's use of humor and that advisee's perception of the advisor's nonverbal immediacy, social support, and mentoring as well as the relationship satisfaction reported by the advisee.Relative Emphasis: theory, research, practice
ADULTS IN MID-CAREER CHANGE: CASE STUDIES FOR ADVISORS
Authors: Dean Gary J. , Eriksen Jan P. , Lindamood Sherie A. 
Published: July 2013

Adults are making mid-career changes more frequently today than ever before. According to Arbeiter et al., over 40,000 Americans are engaging in or anticipating a career change at some time in the future.1 Of these, 60% desire educational and career services. The National Center for Education Statistics reports that over 14,000,000 adults are currently enrolled in two- and four-year college credit courses.2
Three trends have i weased the importance of rumtraditional student programs in many universities across the country: 1) the increase in numbers and visibility of the adult, non-traditional college student population, 2) the stabilization or decrease in the size of the traditional, younger student population, and 3) the expanded services and offerings of programs and courses geared to nontraditional students.3
Thus, academic advisors must be able to understand the needs and motivations of adult learners and to develop advising skills and programs in response to these needs. The purpose of this paper is to outline some of the motivations and needs of both full-time and part-time adult learners who are in transition from work to school and to offer suggestions to academic advisors on how to meet those needs.
Revision surgery is overestimated in hip replacement
Authors: Keurentjes J. C. , Fiocco M. , Schreurs B. W. , Pijls B. G. , Nouta K. A. , Nelissen R. G. H. H. 
Published: July 2013

Objectives The Kaplan-Meier estimation is widely used in orthopedics to calculate the probability of revision surgery. Using data from a long-term follow-up study, we aimed to assess the amount of bias introduced by the Kaplan-Meier estimator in a competing risk setting. Methods We describe both the Kaplan-Meier estimator and the competing risk model, and explain why the competing risk model is a more appropriate approach to estimate the probability of revision surgery when patients die in a hip revision surgery cohort. In our study, a total of 62 acetabular revisions were performed. After a mean of 25 years, no patients were lost to follow-up, 13 patients had undergone revision surgery and 33 patients died of causes unrelated to their hip. Results The Kaplan-Meier estimator overestimates the probability of revision surgery in our example by 3%, 11%, 28%, 32% and 60% at five, ten, 15, 20 and 25 years, respectively. As the cumulative incidence of the competing event increases over time, as does the amount of bias. Conclusions Ignoring competing risks leads to biased estimations of the probability of revision surgery. In order to guide choosing the appropriate statistical analysis in future clinical studies, we propose a flowchart.