bluuebunny/crossref_metadata_2025_split huggingface dataset:
Copper‐Catalyzed Asymmetric Conjugate Addition of Dimethylzinc to Acyl‐N‐methylimidazole Michael Acceptors: a Powerful Synthetic Platform
Authors: Drissi‐Amraoui Sammy , Morin Marie S. T. , Crévisy Christophe , Baslé Olivier , Marcia de Figueiredo Renata , Mauduit Marc , Campagne Jean‐Marc 
Published: August 2015

AbstractAn efficient copper‐catalyzed enantioselective conjugate addition of dimethylzinc to α,β‐ and α,β,γ,δ‐unsaturated 2‐acyl‐N‐methylimidazoles has been achieved using a chiral bidentate hydroxyalkyl‐NHC ligand. The reactions proceeded with both excellent regio‐ and enantioselectivity (14 examples, 87–95 % ee) to afford the desired 1,4‐adducts, which were easily transformed to the corresponding aldehydes, esters, and ketones. Subsequently, this powerful methodology was therefore successfully applied in the synthesis of natural products. Furthermore, an iterative process was also disclosed leading to highly desirable 1,3‐desoxypropionate skeletons (up to 94 % d.e.).
Ruthenium‐Catalyzed meta‐Selective CH Bromination
Authors: Teskey Christopher J. , Lui Andrew Y. W. , Greaney Michael F. 
Published: August 2015

AbstractThe first example of a transition‐metal‐catalyzed, meta‐selective CH bromination procedure is reported. In the presence of catalytic [{Ru(p‐cymene)Cl2}2], tetrabutylammonium tribromide can be used to functionalize the meta CH bond of 2‐phenylpyridine derivatives, thus affording difficult to access products which are highly predisposed to further derivatization. We demonstrate this utility with one‐pot bromination/arylation and bromination/alkenylation procedures to deliver meta‐arylated and meta‐alkenylated products, respectively, in a single step.
Elastin Cables Define the Axial Connective Tissue System in the Murine Lung
Authors: Wagner Willi , Bennett Robert D. , Ackermann Maximilian , Ysasi Alexandra B. , Belle Janeil , Valenzuela Cristian D. , Pabst Andreas , Tsuda Akira , Konerding Moritz A. , Mentzer Steven J. 
Published: August 2015

ABSTRACTThe axial connective tissue system is a fiber continuum of the lung that maintains alveolar surface area during changes in lung volume. Although the molecular anatomy of the axial system remains undefined, the fiber continuum of the lung is central to contemporary models of lung micromechanics and alveolar regeneration. To provide a detailed molecular structure of the axial connective tissue system, we examined the extracellular matrix of murine lungs. The lungs were decellularized using a 24 hr detergent treatment protocol. Systematic evaluation of the decellularized lungs demonstrated no residual cellular debris; morphometry demonstrated a mean 39 ± 7% reduction in lung dimensions. Scanning electron microscopy (SEM) demonstrated an intact structural hierarchy within the decellularized lung. Light, fluorescence, and SEM of precision‐cut lung slices demonstrated that alveolar duct structure was defined by a cable line element encased in basement membrane. The cable line element arose in the distal airways, passed through septal tips and inserted into neighboring blood vessels and visceral pleura. The ropelike appearance, collagenase resistance and anti‐elastin immunostaining indicated that the cable was an elastin macromolecule. Our results indicate that the helical line element of the axial connective tissue system is composed of an elastin cable that not only defines the structure of the alveolar duct, but also integrates the axial connective tissue system into visceral pleura and peripheral blood vessels. Anat Rec, 298:1960–1968, 2015. © 2015 Wiley Periodicals, Inc.
Supramolecular Chemistry in Microflow Fields: Toward a New Material World of Precise Kinetic Control
Authors: Numata Munenori 
Published: August 2015

AbstractConstructing new and versatile self‐assembling systems in supramolecular chemistry is much like the development of new reactions or new catalysts in synthetic organic chemistry. As one such new technology, conventional supramolecular assembly systems have been combined with microflow techniques to control intermolecular or interpolymer interactions through precise regulation of a flowing self‐assembly field. The potential of the microflow system has been explored by using various simple model compounds. Uniform solvent diffusion in the microflow leads to rapid activation of molecules in a nonequilibrium state and, thereby, enhanced interactions. All of these self‐assembly processes begin from a temporally activated state and proceed in a uniform chemical environment, forming a synchronized cluster and resulting in effective conversion to supramolecules, with precise tuning of molecular (or polymer) interactions. This approach allows the synthesis of a variety of discrete microstructures (e.g., fibers, sheets) and unique supramolecules (e.g., hierarchical assemblies, capped fibers, polymer networks, supramolecules with time‐delayed action) that have previously been inaccessible.
Spectral‐converting study of Ba9–3(m+n)/2ErmYbnY2Si6O24 (m = 0.005 – 0.2, n = 0 – 0.3) orthosilicate phosphors
Authors: Choi Seul‐Ki , Park Sangmoon 
Published: August 2015

AbstractOptical materials composed of Ba9–3(m+n)/2ErmYbnY2Si6O24 (m = 0.005–0.2, n = 0–0.3) were prepared using a solid‐state reaction. The X‐ray diffraction patterns of the obtained phosphors were examined to index the peak positions. The photoluminescence (PL) excitation and emission spectra of the Er3+‐activated phosphors and the critical emission quenching as a function of Er3+ content in the Ba9–3m/2ErmY2Si6O24 structure were monitored. The spectral conversion properties of Er3+ and Er3+–Yb3+ ions doped in Ba9Y2Si6O24 phosphors were elucidated under diode‐laser irradiation at 980 nm. Up‐conversion emission spectra and the dependence of the emission intensity on pump power for the Ba8.55Er0.1Yb0.2Y2Si6O24 phosphor were investigated. The desired up‐conversion of the emitted light, which passed through the green, yellow, orange and red regions of the spectrum, was achieved through the use of appropriate Er3+ and/or Yb3+ concentrations in the host structure and 980 nm excitation light. The up‐conversion mechanism in the phosphors is described by an energy‐level schematic. Copyright © 2015 John Wiley & Sons, Ltd.
A T7exonuclease‐assisted target recycling amplification with graphene oxide acting as the signal amplifier for fluorescence polarization detection of human immunodeficiency virus (HIV) DNA
Authors: Wang Lijun , Tian Jianniao , Yang Wen , Zhao Yanchun , Zhao Shulin 
Published: August 2015

AbstractWe report a fluorescence polarization (FP) platform for human immunodeficiency virus (HIV) DNA detection based on T7exonuclease‐assisted target recycling amplification with graphene oxide (GO) acting as a FP signal amplifier. In the sensing method, the presence of the target DNA leads to target recycling with the assistance of T7exonuclease, furthermore, the amplification products are absorbed onto the surface of GO, so the all FP values are enhanced by GO. More importantly, this FP sensor exhibits high detection sensitivity; under optimal conditions, the change in FP is linear with the concentration of the target DNA within a concentration range of 50–2000 pmol/L, and the detection limit of this method is as low as 38.6 pmol/L. This FP sensor also exhibits high selectivity, even single‐base mismatched DNA can be effectively discriminated from complementary target DNA. Above all, the proposed FP sensor may serve as a general platform for the sensitive assay of disease‐related genes. Copyright © 2015 John Wiley & Sons, Ltd.
Spontaneous emission of semiconductor quantum dots in inverse opal SiO2 photonic crystals at different temperatures
Authors: Yang Peng , Yang Yingshu , Wang Yinghui , Gao Jiechao , Sui Ning , Chi Xiaochun , Zou Lu , Zhang Han‐Zhuang 
Published: August 2015

AbstractThe photoluminescence (PL) characteristics of CdSe quantum dots (QDs) infiltrated into inverse opal SiO2 photonic crystals (PCs) are systemically studied. The special porous structure of inverse opal PCs enhanced the thermal exchange rate between the CdSe QDs and their surrounding environment. Finally, inverse opal SiO2 PCs suppressed the nonlinear PL enhancement of CdSe QDs in PCs excited by a continuum laser and effectively modulated the PL characteristics of CdSe QDs in PCs at high temperatures in comparison with that of CdSe QDs out of PCs. The final results are of benefit in further understanding the role of inverse opal PCs on the PL characteristics of QDs. Copyright © 2015 John Wiley & Sons, Ltd.
Selective amine labeling of cell surface proteins guided by coiled‐coil assembly
Authors: Yano Yoshiaki , Furukawa Nami , Ono Satoshi , Takeda Yuki , Matsuzaki Katsumi 
Published: August 2015

ABSTRACTCovalent labeling of target proteins in living cells is useful for both fluorescence live‐cell imaging and the subsequent biochemical analyses of the proteins. Here, we report an efficient method for the amine labeling of membrane proteins on the cell surface, guided by a noncovalent coiled‐coil interaction. A carboxyl sulfosuccinimidyl ester introduced at the C‐terminus of the coiled‐coil probe reacted with target proteins under mild labeling conditions ([probe] = 150 nM, pH 7.4, 25°C) for 20 min. Various fluorescent moieties with different hydrophobicities are available for covalent labeling with high signal/background labeling ratios. Using this method, oligomeric states of glycophorin A (GpA) were compared in mammalian CHO‐K1 cells and sodium dodecyl sulfate (SDS) micelles. In the cell membranes, no significant self‐association of GpA was detected, whereas SDS‐PAGE suggested partial dimerization of the proteins. Membrane cholesterol was found to be an important factor that suppressed the dimerization of GpA. Thus, the covalent functionality enables direct comparison of the oligomeric state of membrane proteins under various conditions. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 484–490, 2016.
Decoding the Chemical Language of Motile Bacteria by Using High‐Throughput Microfluidic Assays
Authors: Crooks John A. , Stilwell Matthew D. , Oliver Piercen M. , Zhong Zhou , Weibel Douglas B. 
Published: August 2015

AbstractMotile bacteria navigate chemical environments by using chemoreceptors. The output of these protein sensors is linked to motility machinery and enables bacteria to follow chemical gradients. Understanding the chemical specificity of different families of chemoreceptors is essential for predicting and controlling bacterial behavior in ecological niches, including symbiotic and pathogenic interactions with plants and mammals. The identification of chemical(s) recognized by specific families of receptors is limited by the low throughput and complexity of chemotaxis assays. To address this challenge, we developed a microfluidic‐based chemotaxis assay that is quantitative, simple, and enables high‐throughput measurements of bacterial response to different chemicals. Using the model bacterium Escherichia coli, we demonstrated a strategy for identifying molecules that activate chemoreceptors from a diverse compound library and for determining how global behavioral strategies are tuned to chemical environments.
Oxidant‐Controlled Catalytic Transformations of Phenols with Unexpected Cleavage of Aromatic Rings
Authors: Li Wei , Song Feijie , You Jingsong 
Published: August 2015

AbstractOxidative transformations of phenols have attracted significant attention of chemists due to their importance in biological process and organic synthesis. In contrast to the relatively well‐developed oxygenation and coupling reactions of phenols, the highly efficient and selective oxidative ring cleavage of phenols is under‐represented. This work describes a novel CuCl‐catalyzed tandem homocoupling/skeletal rearrangement of phenols that realizes the cleavage of the phenol ring by using air or Ag2CO3 as the oxidant. Interestingly, simply changing the oxidant to K2S2O8 results in the oxidative coupling/cyclization of phenols to give dibenzofurans. These results set an important precedent of oxidant‐controlled catalytic transformations of phenols.
Ligand π‐Radical Interaction with f‐Shell Unpaired Electrons in Phthalocyaninato–Lanthanoid Single‐Molecule Magnets: A Solution NMR Spectroscopic and DFT Study
Authors: Damjanović Marko , Morita Takaumi , Katoh Keiichi , Yamashita Masahiro , Enders Markus 
Published: August 2015

AbstractThe phthalocyaninato double‐decker complexes [M(obPc)2]0 (M= YIII, TbIII, DyIII; obPc=2,3,9,10,16,17,23,24‐octabutoxyphthalocyaninato), along with their reduced ([M(obPc)2]−[P(Ph)4]+; M=TbIII, DyIII) and oxidized ([M(obPc)2]+[SbCl6]− (M=YIII, TbIII) counterparts were studied with 1H, 13C and 2D NMR. From the NMR data of the neutral (i.e., with one unpaired electron in the ligands) and anionic TbIII complexes, along with the use of dispersion corrected DFT methods, it was possible to separate the metal‐centered and ligand‐centered contributions to the hyperfine NMR shift. These contributions to the 1H and 13C hyperfine NMR shifts were further analyzed in terms of pseudocontact and Fermi contact shifts. Furthermore, from a combination of NMR data and DFT calculations, we have determined the spin multiplicity of the neutral complexes [M(obPc)2]0 (M=TbIII and DyIII) at room temperature. From the NMR data of the cationic TbIII complex, for which actually no experimental structure determination is available, we have analyzed the structural changes induced by oxidation from its neutral/anionic species and shown that the interligand distance decreases upon oxidation. The fast electron exchange process between the neutral and anionic TbIII double‐decker complexes was also studied.
Peripherally Silylated Porphyrins
Authors: Kato Kenichi , Fujimoto Keisuke , Yorimitsu Hideki , Osuka Atsuhiro 
Published: August 2015

AbstractSilylation of peripherally lithiated porphyrins with silyl electrophiles has realized the first synthesis of a series of directly silyl‐substituted porphyrins. The meso‐silyl group underwent facile protodesilylation, whereas the β‐silyl group was entirely compatible with standard work‐up and purification on silica gel. The meso‐silyl group caused larger substituent effects to the porphyrin compared with the β‐silyl group. Silylation of β‐lithiated porphyrins with 1,2‐dichlorodisilane furnished β‐to‐β disilane‐bridged porphyrin dimers. A doubly β‐to‐β disilane‐bridged NiII‐porphyrin dimer was also synthesized from a β,β‐dilithiated NiII‐porphyrin and characterized by X‐ray crystallographic analysis to take a steplike structure favorable for interporphyrinic interaction. Denickelation of β‐silylporphyrins was achieved upon treatment with a 4‐tolylmagnesium bromide to yield the corresponding freebase porphyrins.
Thermal and Photolytic Transformation of NHC–B,N‐Heterocycles: Controlled Generation of Blue Fluorescent 1,3‐Azaborinine Derivatives and 1 H‐Imidazo[1,2‐a]indoles by External Stimuli
Authors: McDonald Sean M. , Mellerup Soren K. , Peng Jinbao , Yang Dengtao , Li Quan‐Song , Wang Suning 
Published: August 2015

AbstractInvited for the cover of this issue are the groups of Suning Wang at the Queen’s University (Canada) and Quan‐Song Li from Beijing Institute of Technology (P.R. China). The image depicts the unusual and distinct pathways of molecular transformation by N‐heterocyclic carbene bound B,N‐heterocycles. Read the full text of the article at 10.1002/chem.201502385.
Association between medical home enrollment and health care utilization and costs among breast cancer patients in a state Medicaid program
Authors: Kohler Racquel E. , Goyal Ravi K. , Lich Kristen Hassmiller , Domino Marisa Elena , Wheeler Stephanie B. 
Published: August 2015

BACKGROUNDThe patient‐centered medical home (PCMH) is increasingly being implemented in an effort to improve and coordinate primary care, but its effect on health care utilization among breast cancer patients remains unclear. The objective of this study was to examine health care utilization and expenditures as a function of PCMH enrollment among breast cancer patients in North Carolina's Medicaid program.METHODSNorth Carolina Medicaid claims linked to North Carolina Central Cancer Registry records (2003‐2007) were used to examine monthly patterns of health care use and expenditures. Controlling for a selection bias for time‐invariant characteristics, fixed effects regression models analyzed associations between PCMH enrollment and utilization of outpatient, inpatient, and emergency department (ED) services and Medicaid expenditures during the 15 months after the diagnosis of breast cancer.RESULTSAmong 758 breast cancer patients, 381 (50%) were enrolled in a PCMH at some time in the 15 months after diagnosis. After controlling for individual fixed effects, PCMH enrollment was significantly associated with greater outpatient service use, but there was no difference in the probability of inpatient hospitalizations or ED visits. Enrollment in a PCMH was associated with increased average expenditures of $429 per month during the first 15 months.CONCLUSIONSGreater outpatient care utilization and increased average expenditures among breast cancer patients enrolled in a PCMH may suggest that these women have improved access to primary and specialty care. Expanding PCMHs may change patterns of service utilization for Medicaid breast cancer patients but may not be associated with lower costs. Cancer 2015;121:3975–3981. © 2015 American Cancer Society.
A high frequency of BRCA mutations in young black women with breast cancer residing in Florida
Authors: Pal Tuya , Bonner Devon , Cragun Deborah , Monteiro Alvaro N.A. , Phelan Catherine , Servais Lily , Kim Jongphil , Narod Steven A. , Akbari Mohammad R. , Vadaparampil Susan T. 
Published: August 2015

BACKGROUNDBlack women are disproportionately affected with triple‐negative breast cancer and have relatively poor survival. To the authors' knowledge, it is not known to what extent differences in the clinical presentation of breast cancer between non‐Hispanic white women and black women can be accounted for by the presence of mutations in the BRCA1 and BRCA2 genes. The authors sought to evaluate the frequency of BRCA pathogenic variants in a population‐based sample of young black women with breast cancer.METHODSBlack women diagnosed with invasive breast cancer at age ≤50 years from 2009 to 2012 were recruited to the study through the Florida Cancer Registry. Participants underwent genetic counseling, completed a study questionnaire, and consented to release of their medical records. Saliva specimens were collected for BRCA sequencing and large rearrangement testing through multiplex ligation‐dependent probe amplification.RESULTSA DNA sample was evaluated for 396 women, 49 of whom (12.4%) had a mutation in BRCA1 or BRCA2. Eight recurrent mutations accounted for 49% of all pathogenic variants.CONCLUSIONSTo the authors' knowledge, the prevalence of BRCA mutations among the Florida‐based sample of young black women with breast cancer in the current study exceeds that previously reported for non‐Hispanic white women. It is appropriate to recommend BRCA testing in all young black women with invasive breast cancer. Cancer 2015;121:4173–4180. © 2015 American Cancer Society.
Resilience, health, and quality of life among long‐term survivors of hematopoietic cell transplantation
Authors: Rosenberg Abby R. , Syrjala Karen L. , Martin Paul J. , Flowers Mary E. , Carpenter Paul A. , Salit Rachel B. , Baker K. Scott , Lee Stephanie J. 
Published: August 2015

BACKGROUNDLow patient‐reported resilience is associated with an ongoing risk of poor health and psychosocial outcomes. Using a large cross‐sectional sample of survivors of hematopoietic cell transplantation (HCT), this study explored associations between patient‐reported resilience, psychological distress, posttraumatic growth, and health‐related quality of life.METHODSBetween July 1, 2013 and June 30, 2014, the annual Fred Hutchinson Cancer Research Center (FHCRC) posttransplant survivorship survey queried patient‐reported health and functional status and included instruments assessing psychosocial outcomes: the 10‐item Connor‐Davidson Resilience Scale, the Posttraumatic Growth Inventory, the Cancer and Treatment Distress measure, and the 12‐item Medical Outcomes Study Short Form quality‐of‐life scale. Multivariate linear and logistic regression models included demographic and health covariates extracted from the FHCRC research database.RESULTSAmong 4643 adult survivors of HCT, 1823 (39%) responded after a single mailing and subsequent reminder letter. The participants' median age was 59 years (interquartile range [IQR], 50‐66 years); 52.5% were male, and most were non‐Hispanic white. The median time since HCT was 9 years (IQR, 3‐18 years). Lower patient‐reported resilience was associated with chronic graft‐versus‐host disease of higher severity, lower performance scores, missing work because of health, and permanent disability (all P < .0001). After adjustments for demographic and health characteristics, patients reporting low resilience scores had higher odds of having psychological distress (odds ratio [OR], 3.0; 95% confidence interval [CI], 2.1‐4.3) and being in the lowest quartile for mental health–related quality of life (OR, 5.9; 95% CI, 4.4‐8.0).CONCLUSIONSPatient‐reported resilience is independently associated with health and psychosocial outcomes. Future studies must determine whether interventions can bolster resilience and improve survivorship outcomes. Cancer 2015;121:4250–4257. © 2015 American Cancer Society.
Pax3 and Pax7 interact reciprocally and regulate the expression of cadherin‐7 through inducing neuron differentiation in the developing chicken spinal cord
Authors: Lin Juntang , Wang Congrui , Yang Ciqing , Fu Sulei , Redies Christoph 
Published: August 2015

ABSTRACTPax3 and Pax7 are closely related transcription factors that are widely expressed in the developing nervous system and somites. In the CNS, both genes are expressed in the dorsal part of the neural tube during development. Pax3 and Pax7 are involved in the sonic hedgehog (Shh) signaling pathway and are inhibited by Shh overexpression. The present study confirms in vivo that Pax3 overexpression represses the expression of Pax7, whereas Pax7 overexpression endogenously enhances and ectopically induces the expression of Pax3 in the developing chicken spinal cord. Overexpression of Pax3 and Pax7 represses the endogenous expression of cadherin‐7, a member of the cadherin family of morphogenetic genes, and induces its ectopic expression. The present study also shows that overexpression of Pax3 and Pax7 changes the fate and morphology of cells in the neuroepithelial layer and induces the expression of postmitotic neuronal markers. We show that both Pax3 and Pax7 promote the differentiation of neural progenitor cells into neurons. Furthermore, the downregulation of Pax3 and Pax7 with specific shRNAs results in apoptosis in the developing spinal cord. Collectively, these results suggest that the transcription factors Pax3 and Pax7 play important roles in regulating morphogenesis and cell differentiation in the developing spinal cord. J. Comp. Neurol. 524:940–962, 2016. © 2015 Wiley Periodicals, Inc.