bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orbital motion of NGC 6166 (3C 338) and its impact on the jet morphology at kiloparsec scales
Authors: Antas A S R , Caproni A , Machado R E G , Laganá T F , Souza G S 
Published: August 2024

ABSTRACT
In the central region of the galaxy cluster, Abell 2199 (A 2199) resides the cD galaxy NGC 6166, which spatially coincides with the 3C 338 radio source. Lobes, jets, and a more detached southern structure (similar to a jet labelled as ridge) are seen at kiloparsec-scale images of 3C 338. This unusual radio morphology has led to the proposition of different hypotheses about its physical origin in the literature. In this work, we study the feasibility of a dynamical scenario where NGC 6166 moves around the X-ray inferred centre of A 2199 from the point of view of three-dimensional hydrodynamic simulations. The physical characteristics of the intracluster medium in which the jet propagates are constrained to those derived from X-ray observations in the vicinity of NGC 6166. Possible orbits for the jet inlet region are derived from the estimated radial velocity of NGC 6166, while the jet parameters are constrained by parsec-scale interferometric radio observations and the estimated jet power of 3C 338 obtained from radio and X-ray data. Our results show that the hypothesis of NGC 6166 has been moving around the centre of A 2199 during the last tens of million of years is compatible with the general radio morphology of 3C 338. Furthermore, the proposed dynamic scenario for the motion of NGC 6166 may be linked to gravitational perturbations induced by the passage of a sub-cluster of galaxies hundreds of millions of years ago.
Löfgren syndrome, characteristics of Japanese cases: A case and a review of the literature
Authors: Taguchi Hirokazu , Sumitomo Shuji , Oka Hideki , Hara Shigeo , Ohmura Koichiro 
Published: August 2024

ABSTRACT
Löfgren syndrome (LS) is a sarcoidosis subtype characterised by an acute disease course, bilateral hilar lymphadenopathy (BHL), erythema nodosum (EN), and ankle arthritis. LS in Caucasians appears to be self-limiting; however, our patients require glucocorticoid (GC) treatment. Here, we present a case of LS and review the literature to identify the characteristics of Japanese patients with LS. A 66-year-old woman was referred to Kobe City Medical Center General Hospital; she initially presented with an acute onset of low-grade fever and ankle arthritis, followed by EN. Skin biopsy revealed a noncaseating granuloma, and a chest computed tomography scan displayed BHL; she was diagnosed with LS. Her arthralgia ameliorated spontaneously, but the erythema persisted, necessitating GC treatment. A literature review revealed that the Japanese LS patients showed more fever, were more frequently treated with GCs, and more patients seemed to relapse, which may be explained by the absence of human leucocyte antigen–DR isotype 3, a good prognostic allele in Caucasians. Japanese LS may cause severe symptoms after development because of the differences in human leucocyte antigens from foreign countries. For early diagnosis, it is important to evaluate EN and BHL in patients with polyarthritis involving ankle arthralgia.
A case of Buerger’s disease with vasculopathy and skin fibrosis requiring differential diagnosis from systemic sclerosis
Authors: Funada Masashi , Nakayamada Shingo , Fukuyo Shunsuke , Kubo Satoshi , Nawata Aya , Fujita Yuya , Tanaka Yoshiya 
Published: August 2024

ABSTRACT
Buerger’s disease is characterised by peripheral ischaemia due to occlusion of small- and medium-sized arteries in the extremities. This report describes a case of Buerger’s disease in a 51-year-old male who presented with findings resembling systemic sclerosis (SSc). The patient exhibited Raynaud’s phenomenon in year 2015, which developed to skin hardening, nail avulsion, and ulceration of the right fingers in year 2018. Diagnostic testing showed positive microvasculopathy on nailfold videocapillaroscopy (NVC) and positive fibrosis on skin biopsy. Although the patient fulfilled the 2013 American College of Rheumatology/European League Against Rheumatism classification criteria for SSc, several findings in this case were atypical for SSc, including left-right asymmetry in finger involvement, nail loss, and negative autoantibody tests. Contrast-enhanced computed tomography showed poor perfusion of the right ulnar artery, and a heavy smoking history was established in the patient case. Therefore, based on Shionoya’s criteria, he was diagnosed with a case of Buerger’s disease confined to the upper extremity. Smoking cessation and vasodilator therapy resulted in the prompt resolution of ischaemic symptoms, skin hardening, and ulcerations. Furthermore, NVC abnormalities improved, and ulnar artery occlusion showed reperfusion on repeat testing. The present case suggests that hypoxaemia-driven microvasculopathy may contribute to vascular occlusion and skin fibrosis observed in this atypical presentation.
Paediatric SAPHO syndrome with pleural effusion: Case report of a unique finding in a rare disease
Authors: Kruger Christopher , Wang Christine , Grim Andrew 
Published: August 2024

ABSTRACT
Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome is a rare autoinflammatory disease characterised by bone inflammation and skin manifestations including acne, palmoplantar pustulosis, psoriasis, or hidradenitis suppurativa. SAPHO syndrome is considered on the same spectrum as chronic nonbacterial osteomyelitis/chronic recurrent multifocal osteomyelitis, the former often being the nomenclature in adults and the latter in children. The diagnosis is made on patterns of clinical manifestations and is a diagnosis of exclusion. While skin and bone manifestations are commonly described with SAPHO syndrome, pleural involvement is rare, and few cases have been described in the literature, especially in paediatric patients. Herein we present a 14-year-old female with a past medical history of hidradenitis supprtiva, eczema, psoriasis, and a prior episode of culture-negative osteomyelitis who presented to the emergency room with chief complaints of right-sided pain with inspiration and back pain. Exam revealed palmoplantar pustulosis, hidradenitis supprativa, psoriasis, and tenderness of vertebrae. Imaging showed a right-sided pleural effusion and multiple sites of osteitis. Laboratory evaluation revealed elevated inflammatory markers, an exudative pleural effusion with neutrophilic predominance, and no evidence of malignancy, infection, or immunodeficiency. The patient was diagnosed with SAPHO syndrome and treated with naproxen, methotrexate, and golimumab with significant improvement including resolution of the pleural effusion. Paediatric SAPHO syndrome is a rare disease that classically causes osteitis and skin manifestations. This case highlights that pleural effusion can be a rare manifestation of paediatric SAPHO syndrome. Patients with suspected SAPHO syndrome with respiratory symptoms should be evaluated for pleural effusion.
TRF2–RAP1 represses RAD51-dependent homology-directed telomere repair by promoting BLM-mediated D-loop unwinding and inhibiting BLM–DNA2-dependent 5′-end resection
Authors: Liang Fengshan , Rai Rekha , Sodeinde Tori , Chang Sandy 
Published: August 2024

Abstract
Inappropriate homology-directed repair (HDR) of telomeres results in catastrophic telomere loss and aberrant chromosome fusions, leading to genome instability. We have previously shown that the TRF2–RAP1 heterodimer protects telomeres from engaging in aberrant telomere HDR. Cells lacking the basic domain of TRF2 and functional RAP1 display HDR-mediated telomere clustering, resulting in the formation of ultrabright telomeres (UTs) and massive chromosome fusions. Using purified proteins, we uncover three distinct molecular pathways that the TRF2–RAP1 heterodimer utilizes to protect telomeres from engaging in aberrant HDR. We show mechanistically that TRF2–RAP1 inhibits RAD51-initiated telomeric D-loop formation. Both the TRF2 basic domain and RAP1-binding to TRF2 are required to block RAD51-mediated homology search. TRF2 recruits the BLM helicase to telomeres through its TRFH domain to promote BLM-mediated unwinding of telomere D-loops. In addition, TRF2–RAP1 inhibits BLM–DNA2-mediated 5′ telomere end resection, preventing the generation of 3′ single-stranded telomere overhangs necessary for RAD51-dependent HDR. Importantly, cells expressing BLM mutants unable to interact with TRF2 accumulate telomere D-loops and UTs. Our findings uncover distinct molecular mechanisms coordinated by TRF2–RAP1 to protect telomeres from engaging in aberrant HDR.
Bladder cancer with bone marrow metastases and thrombotic microangiopathy: a case report
Authors: Yousf Khder , Daoud Nagham , Habib Ali , Salloum Rabab , Hussein Firas 
Published: August 2024

Abstract
Bladder cancer is one of the most common cancers of the urinary tract and the 10th most common cancer worldwide according to the World Health Organization (WHO), with a higher incidence in men than in women. Bladder cancer rarely presents with a clinical picture of bone marrow infiltration which may result in thrombotic microangiopathy (TMA). TMA is a syndrome triggered by a wide variety of conditions, some of which are associated with cancer. It is a rare condition in patients with solid tumors, the incidence of which is increasing as awareness of this complication improves. Tumor-induced TMA may exhibit a wide spectrum of clinical manifestations. Here we review the case of a 57-year-old male suffering from transitional bladder cancer with bone marrow infiltration that led to TMA Syndrome. We were able to diagnose the cause and treat the patient in a manner that achieved complete remission of symptoms.
Transcription factor NAC78 cooperates with NAC78 interacting protein 6 to confer drought tolerance in rice
Authors: Yu Xiangzhen , Xie Yunjie , Wang Lanning , Li Lele , Jiang Shengfei , Zhu Yongsheng , Xie Hongguang , Cui Lili , Wei Yidong , Xiao Yanjia , Cai Qiuhua , Zheng Yanmei , Chen Liping , Xie Huaan , Zhang Jianfu 
Published: August 2024

Abstract
NAC (NAM, ATAF1/2, and CUC2) family transcription factors are involved in several cellular processes, including responses to drought, salinity, cold, and submergence. However, whether or how certain NAC proteins regulate drought tolerance in rice (Oryza sativa) remain unclear. In this study, we show that overexpression of OsNAC78 enhanced rice resistance to drought treatment, whereas Osnac78 mutant plants were susceptible to drought stress. We further characterized the OsNAC78 interacting protein, named NAC78 interacting protein 6 (OsNACIP6), and found that it conferred rice drought tolerance. Our results demonstrate that OsNACIP6 enhanced the transcription of OsNAC78 and promoted the expression of its downstream target OsGSTU37, encoding a glutathione reductase. The ABRE4 cis-element in the promoter region of OsNACIP675–1–127 conferred significant upregulation of OsNACIP6 expression and initiated the OsNACIP6/OsNAC78–OsGSTU37 module that facilitates rice growth under drought conditions. Together, our results uncover a transcriptional module composed of OsNACIP6, OsNAC78, and OsGSTU37 and provide insights into the molecular mechanisms underlying the drought stress response in rice.
Phishing vulnerability compounded by older age, apolipoprotein E e4 genotype, and lower cognition
Authors: Pehlivanoglu Didem , Shoenfelt Alayna , Hakim Ziad , Heemskerk Amber , Zhen Jialong , Mosqueda Mario , Wilson Robert C , Huentelman Matthew , Grilli Matthew D , Turner Gary , Spreng R Nathan , Ebner Natalie C 
Published: August 2024

Abstract
With technological advancements, financial exploitation tactics have expanded into the online realm. Older adults may be particularly susceptible to online scams due to age- and Alzheimer's disease-related changes in cognition. In this study, 182 adults ranging from 18 to 90 years underwent cognitive assessment, genotyping for apolipoprotein E e4 (APOE4), and completed the lab-based Short Phishing Email Suspicion Test (S-PEST) as well as the real-life PHishing Internet Task (PHIT). Across both paradigms, older age predicted heightened susceptibility to phishing, with this enhanced susceptibility pronounced among older APOE4 allele carriers with lower working memory. Additionally, performance in both phishing tasks was correlated in that reduced ability to discriminate between phishing and safe emails in S-PEST predicted greater phishing susceptibility in PHIT. The current study identifies older age, APOE4, and lower cognition as risk factors for phishing vulnerability and introduces S-PEST as an easy-to-administer, ecologically valid tool for assessing phishing susceptibility.
The dynamics of the midgut microbiome in Aedes aegypti during digestion reveal putative symbionts
Authors: Salgado João Felipe M , Premkrishnan Balakrishnan N V , Oliveira Elaine L , Vettath Vineeth Kodengil , Goh Feng Guang , Hou Xinjun , Drautz-Moses Daniela I , Cai Yu , Schuster Stephan C , Junqueira Ana Carolina M 
Published: August 2024

Abstract
Blood-feeding is crucial for the reproductive cycle of the mosquito Aedes aegypti, as well as for the transmission of arboviruses to hosts. It is postulated that blood meals may influence the mosquito microbiome but shifts in microbial diversity and function during digestion remain elusive. We used whole-genome shotgun metagenomics to monitor the midgut microbiome in 60 individual females of A. aegypti throughout digestion, after 12, 24, and 48 h following blood or sugar meals. Additionally, ten individual larvae were sequenced, showing microbiomes dominated by Microbacterium sp. The high metagenomic coverage allowed for microbial assignments at the species taxonomic level, also providing functional profiling. Females in the post-digestive period and larvae displayed low microbiome diversities. A striking proliferation of Enterobacterales was observed during digestion in blood-fed mosquitoes. The compositional shift was concomitant with enrichment in genes associated with carbohydrate and protein metabolism, as well as virulence factors for antimicrobial resistance and scavenging. The bacterium Elizabethkingia anophelis (Flavobacteriales), a known human pathogen, was the dominant species at the end of blood digestion. Phylogenomics suggests that its association with hematophagous mosquitoes occurred several times. We consider evidence of mutually beneficial host-microbe interactions raised from this association, potentially pivotal for the mosquito's resistance to arbovirus infection. After digestion, the observed shifts in blood-fed females’ midguts shifted to a sugar-fed-like microbial profile. This study provides insights into how the microbiome of A. aegypti is modulated to fulfil digestive roles following blood meals, emphasizing proliferation of potential symbionts in response to the dynamic midgut environment.
Systematic Effects on Lensing Reconstruction from a Patchwork of CMB Polarization Maps
Authors: Nagata Ryo , Namikawa Toshiya 
Published: August 2024

Abstract
We investigate the tolerance for systematic errors in lensing analysis applied to a patchwork map of Cosmic Microwave Background polarization. We focus on the properties of the individual polarization maps that comprise the patchwork and discuss the associated calibration residuals that are coherent on those subpatches. We numerically simulate the polarization field modulated as a whole patchwork and apply a suite of lensing analyses to reveal the response of the reconstructed gravitational lensing potential and delensing efficiency. At systematic error levels expected in the near future, we find that it is possible to reconstruct the lensing potential accurately on scales larger than the subpatch size and that there is no severe degradation of the lensing B-mode removal efficiency in the subsequent delensing analysis.
The development of pGALSplus: evaluating feasibility and acceptability of an assessment to facilitate the identification and triage of children with musculoskeletal presentations
Authors: Mercer Vicky , Smith Nicola , Guglieri Michela , Jones Simon A , Parr Jeremy R , Foster Helen E , Jandial Sharmila 
Published: August 2024

Abstract

Objectives
Healthcare professionals (HCPs) need to identify potentially serious musculoskeletal (MSK) presentations in children and refer them to specialists appropriately. Our aim was to develop ‘pGALSplus’ (paediatric gait, arms, legs and spine plus) to support clinical assessment, aid decision-making and assess feasibility and acceptability in exemplar MSK pathologies.

Methods
We used a three-phase mixed methods approach: phase 1, preliminary stakeholder engagement and scoping review to propose pGALSplus; phase 2, iterative development of pGALSplus involving an expert working group; and phase 3, testing the feasibility of pGALSplus in exemplar MSK conditions [JIA, mucopolysaccharidoses (MPS), muscular dystrophy (MD), developmental coordination disorder (DCD) and healthy controls (HCs)]. The final pGALSplus was derived from analysis of phase 3 data and feedback from HCPs, families and expert consensus input from an international e-survey (n = 22) and virtual event (n = 13).

Results
Feasibility was tested in 45 children (JIA, n = 10; MPS, n = 6; MD, n = 9; DCD, n = 10; HCs, n = 10). Overall the assessment was achievable in the target age range (2–10 years) and quick to complete [median 12 min (range 8–20)], with high acceptability from families. Expert feedback deemed pGALSplus to be very useful and of particular use to non-specialists in MSK paediatrics. The final pGALSplus comprises 26 clinical observations/skills with a colour-coding approach to aid decision-making and identification of more serious MSK presentations and additional resources to support its use in clinical practice.

Conclusions
pGALSplus is a novel evidence- and consensus-based assessment building on pGALS, with high acceptability and feasibility. As community-based MSK assessment in children becomes more established, we propose that pGALSplus will facilitate and inform decision-making to promote access to specialist care.
Effect of an algae feed additive on reducing enteric methane emissions from cattle
Authors: Colin Reba L , Sperber Jessica L , Buse Kassidy K , Kononoff Paul J , Watson Andrea K , Erickson Galen E 
Published: August 2024

Abstract
Alga 1.0, a product containing bromoform, was fed to cattle to evaluate its effects on methane (CH4) and carbon dioxide (CO2) emissions and diet digestibility. Twelve nonlactating, nonpregnant Jersey cows (490 ± 19 kg body weight) were used in four replicated 3 × 3 Latin squares with three periods, each consisting of 21 d. Cows were blocked by feed intake (averaged intakes over 4 wk prior to trial) and assigned randomly to one of three treatments. Treatments included Alga 1.0 fed at 0, 69, and 103 g/d in a 0.454 kg/d dry matter (DM) top-dress daily in a modified distillers grains plus solubles (MDGS) carrier. Diet consisted of 60% dry-rolled corn, 20% corn silage, 15% modified distillers grains, and 5% supplement (DM basis). Headbox-style indirect calorimeters were utilized to evaluate gas production from individual cows with two nonconsecutive 23-h collections in each period. Data were analyzed using the GLIMMIX procedure of SAS with cow within square as experimental unit and as a random effect, and treatment and period as fixed effects. Linear and quadratic contrasts were used to compare treatments. Feeding Alga 1.0 linearly reduced dry matter intake (DMI, P &lt; 0.01) by 10.1% for 69 g/d inclusion and 13.3% for 103 g/d inclusion compared to the control. Nutrient intakes decreased linearly (P &lt; 0.01) due to lower DMI, but nutrient digestibility was not impacted (P ≥ 0.28). Inclusion of Alga 1.0 did not impact gross energy or digestible energy concentration of the diets expressed as Mcal/kg DM (P ≥ 0.22) but did linearly reduce energy intake (Mcal/d; P &lt; 0.01). Feeding Alga 1.0 linearly reduced enteric CH4 emissions measured as g/kg DMI (P &lt; 0.01) by 39 and 64% for 69 g/d and 103 g/d inclusion, respectively. Linear reductions (P &lt; 0.01) of 64% to 65% were also observed in enteric CH4 emissions when expressed per kilogram of DM or organic matter digested. Respired CO2 as g/d linearly decreased (P = 0.03) for cattle fed Alga 1.0 but did not differ when expressed as g/kg of DMI (P ≥ 0.23). Oxygen consumption did not differ between treatments for g/d and g/kg DMI (P ≥ 0.19). In conclusion, feeding Alga 1.0 reduced DMI up to 13.3%, did not impact digestibility, and significantly reduced CH4 emissions up to 63%.
The Unidroit Principles and the Shari’ah Standards: any room for cooperation?
Authors: Berrahlia Badreddine 
Published: August 2024

Abstract
This article presents potential cooperation between the Unidroit Principles of International Commercial Contracts (Unidroit Principles) and the Shari’ah Standards (SSs) issued by the Accounting and Auditing Organization for Islamic Financial Institutions. It starts from the new trend that considers the contribution of soft law to resolving disputes in international commercial contracts: the 2015 Hague Principles, the 2019 Guide, and the 2023 African Principles. The article evaluates the SS-making process by using the input-process-output model and proposes a legal basis and scenarios for cooperation between the Unidroit Principles and the SSs in international commercial dispute resolutions. It then explores some divergences that limit the scope of this cooperation. The article recommends the publication of SSs concerned with invalidity and the three defects of consent: mistake, fraud, and threat. It also emphasizes the need to set up model clauses for Islamic finance cross-border contracts, including cooperation with the Unidroit Principles and publishing online case law.
Comparison Between Resident and Attending Surgeons as Assistants on Adolescent Idiopathic Scoliosis Surgery
Authors: Barile Francesca , Ruffilli Alberto , Cerasoli Tosca , Manzetti Marco , Viroli Giovanni , Traversari Matteo , Mazzotti Antonio , Faldini Cesare 
Published: August 2024

Study Design:
Retrospective cohort study.

Objective:
The aim of the present study was to determine if the level of training of the first assistant (resident or attending surgeon) has an influence on the radiographic outcome of AIS surgery and on the accuracy rate of the pedicle screws placement.

Summary of Background Data:
Adolescent idiopathic scoliosis (AIS) surgery is a challenging procedure that requires a dedicated team of skilled professionals. Therefore, understanding the learning curve is of outstanding importance to guarantee the best outcomes and the highest safety to the patients.

Methods:
A retrospective analysis of patients who underwent surgery for AIS with a minimum follow-up of 2 years was conducted. All patients were operated by an experienced spine surgeon, assisted by and attending surgeon (group A) or a senior resident (group B). Radiographic outcomes were assessed. Through postoperative CT scan, accuracy of pedicle screw placement was measured (using Gertzbein-Robbins classification). Groups were then statistically compared.

Results:
A total of 120 patients were included (mean age 15.3±3.39 y, major curve Cobb 60.7±11.9 degrees). No difference was found between groups in terms of preoperative characteristics and postoperative radiographic (correction rate, thoracic kyphosis, screw density) outcomes or complications. Operative time and estimated blood loss were significantly higher in Group B (P=0.045 and P=0.024, respectively). Of the 2746 pedicle screws inserted (1319 group A and 1427 group B), 2452 had a perfect intrapedicular trajectory (absolute accuracy of 89.29%) and 2697 had a breach <2 mm (relative accuracy of 97.56%). No difference was found among groups in terms of absolute or relative accuracy (P=0.06 and P=0.23, respectively).

Conclusions:
AIS cases assisted by senior residents have longer operative time and higher blood loss, but this does not negatively affect the overall radiographic outcome and does not place the patient at increased risk of complications.

Level of Evidence:
III.