bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune Complexes Inhibit IL-1 Secretion and Inflammasome Activation
Authors: Janczy John R. , Ciraci Ceren , Haasken Stefanie , Iwakura Yoichiro , Olivier Alicia K. , Cassel Suzanne L. , Sutterwala Fayyaz S. 
Published: October 2014

Abstract
IgG immune complexes have been shown to modify immune responses driven by APCs in either a pro- or anti-inflammatory direction depending upon the context of stimulation. However, the ability of immune complexes to modulate the inflammasome-dependent innate immune response is unknown. In this study, we show that IgG immune complexes suppress IL-1α and IL-1β secretion through inhibition of inflammasome activation. The mechanism by which this inhibition occurs is via immune complex ligation of activating FcγRs, resulting in prevention of both activation and assembly of the inflammasome complex in response to nucleotide-binding domain leucine-rich repeat (NLR) P3, NLRC4, or AIM2 agonists. In vivo, administration of Ag in the form of an immune complex during priming of the immune response inhibited resultant adaptive immune responses in an NLRP3-dependent model of allergic airway disease. Our data reveal an unexpected mechanism regulating CD4+ T cell differentiation, by which immune complexes suppress inflammasome activation and the generation of IL-1α and IL-1β from APCs, which are critical for the Ag-driven differentiation of CD4+ T cells.
The Salivary Scavenger and Agglutinin in Early Life: Diverse Roles in Amniotic Fluid and in the Infant Intestine
Authors: Reichhardt Martin Parnov , Jarva Hanna , de Been Mark , Rodriguez Juan Miguel , Jimenez Quintana Esther , Loimaranta Vuokko , Meindert de Vos Willem , Meri Seppo 
Published: October 2014

Abstract
The salivary scavenger and agglutinin (SALSA), also known as gp340 and dmbt1, is an antimicrobial and inflammation-regulating molecule located at the mucosal surfaces. The present study revealed that SALSA was present in the amniotic fluid (AF) and exceptionally enriched in both meconium and feces of infants. Based on immunological and mass spectrometric analysis, SALSA was estimated to constitute up to 4–10% of the total protein amount in meconium, making it one of the most abundant proteins. SALSA proteins in the AF and intestinal samples were polymorphic and exhibited varying polypeptide compositions. In particular, a different abundance of peptides corresponding to functionally important structures was found in the AF and intestinal SALSA. The AF form of SALSA had a more intact structure and contained peptides from the zona pellucida domain, which is involved in cell differentiation and oligomerization. In contrast, the intestinal SALSA was more enriched with the scavenger receptor cysteine-rich domains. The AF, but not the meconium SALSA, bound to Streptococcus pyogenes, S. agalactiae, S. gordonii, and Escherichia coli. Furthermore, differential binding was observed also to known endogenous ligands C1q, mannose-binding lectin, and secretory IgA. Our results have thus identified mucosal body compartments, where SALSA is particularly abundant, and suggest that SALSA exhibits varying functions in the different mucosal locations. The high levels of SALSA in AF and the infant intestine suggest a robust and important function for SALSA during the fetal development and in the mucosal innate immune defense of infants.
Absence of Nkx2-3 Homeodomain Transcription Factor Reprograms the Endothelial Addressin Preference for Lymphocyte Homing in Peyer’s Patches
Authors: Kellermayer Zoltán , Mihalj Martina , Lábadi Árpád , Czömpöly Tamás , Lee Mike , O’Hara Edward , Butcher Eugene C. , Berta Gergely , Balogh András , Arnold Hans-Henning , Balogh Péter 
Published: October 2014

Abstract
Although the homing of lymphocytes to GALT has been extensively studied, little is known about how high endothelial venules (HEVs) within Peyer’s patches (PPs) are patterned to display dominantly mucosal addressin cell adhesion molecule 1 (MAdCAM-1). In this study, we report that Nkx2-3–deficient mice show gradual loss of MAdCAM-1 in PPs postnatally and increased levels of mRNA for peripheral lymph node addressin (PNAd) backbone proteins as well as enhanced expression of MECA79 sulfated glycoepitope at the luminal aspect of HEVs, thus replacing MAdCAM-1 with PNAd. Induction of PNAd in mutant PPs requires lymphotoxin β receptor activity, and its upregulation needs the presence of mature T and B cells. Furthermore, treatment with MECA-79 anti-PNAd mAb in vivo effectively blocks lymphocyte homing to mutant PPs. Despite the replacement of MAdCAM-1 by PNAd in HEV endothelia, lymphocytes could efficiently home to PPs in mutant mice. We conclude that although Nkx2-3 activity controls the addressin balance of HEVs in GALT, the general HEV functionality is preserved independently from Nkx2-3, indicating a substantial plasticity in the specification of GALT HEV endothelium.
Editorial
Authors: Akser Murat 
Published: October 2014

This issue of CINEJ focuses on a varity of topics: American tourism to Mexico and 1950s Hollywood film, cinematic pedagogy of Gilles Deleuze and Manoel de Oliveira, United Arab Emirates building a national cinema, crowdfunding in documentaries, flying scenes in Steven Spielberg's films, Rudaali in film narrative, a brief history of motorcycle in cinema, romantic relief in the Hollywood Blockbuster, filmosphy of Turkish cinema and flash animation as a counter cultural tool.
Recurrence: A Filmosophic Re-thinking of A Long Story/ Uzun Hikaye
Authors: Goksel Demiray Basak 
Published: October 2014

This study will re-think A Long Story under the guidance of Daniel Frampton’s perspective of “filmosophy” which theorises film as a ‘being’ independent from any external effect, and acknowledges that film has a ‘mind’ and is ‘able to think’ in its own way. To be clear on re-thinking how A Long Story ‘thinks’ of the concept of ‘recurrence’ in its dramatic structure, this study first will give a detailed explanation of “filmosophy”. Then, it will elaborate the particular ‘intentions’ and ‘choices’ that the film is responsible of whilst constructing itself upon the idea of ‘recurrence’. Finally, this study will focus on a particular scene and explain its significance on locating ‘recurrence’ as the ‘whole knowledge’ the film keeps in mind.
Biotechnology lessons for robotics: Adapting new business models to accelerate innovation
Authors: Boni Arthur , Moehle Christopher 
Published: October 2014

Abstract â€“ The robotics industry is achieving a level of commercial maturity as evidenced by innovative products brought to market, and by the increasing pace of emerging robotics companies being acquired by larger players in a diversity of industries. However, there are challenges with accelerating the rate and scale of innovation in this industry. Our hypothesis is that while there are remaining technological challenges, the largest challenge is for the industry to adapt by exploitation of business models that focus more intently on validating product/market fit, building teams to span seamlessly from laboratory to market, and on developing creative structure and vehicles to provide the needed resources to commercialize.Â To this end, we suggest that the robotics field could adapt approaches from the emerging â€œbusiness model playbookâ€ that are now being used in the field of biotechnology.Â These industries do compare somewhat in that they are each technologically driven, have long, high- risk development cycles, and have the need for high levels of capital, compared to the software industry.Â In this paper we review what has been accomplished in biotechnology, and also suggest how these lessons could be implemented in the field of robotics.Â
What the patent dance of the Biosimilars Act means for biosimilars
Authors: Fazzolare David A. , Brougher Joanna 
Published: October 2014

There are currently only two biosimilars on the market in the US in contrast to the 21 biosimilars have been approved in Europe since 2006.Â Part of the reason for the lack of biosimilars is that until recently, there has been no abbreviated pathway for a biosimilar to reach the market meaning that biosimilars had to undergo the long and costly process of obtaining approval just like an innovator biologic product. After years of negotiation, however, the Biologics Price Competition and Innovation Act (the â€œBiosimilars Actâ€) was signed into law on March 23, 2010, by President Obama as Title VII of the Patent Protection and Affordable Care Act.Â The Biosimilars Act established an abbreviated pathway by which the FDA could approve generic versions of previously licensed biological products. The Biosimilars Act sets forth several requirements for biosimilar applications, including the so-called â€œPatent Danceâ€ which describes the process by which the biosimilar applicant and the reference product sponsor (â€œRPSâ€) exchange patent-related information before the biosimilar can enter the market.Â In this article, we will explore what the Patent Dance is and what it means for biosimilars that are seeking market entry in the US.Â
Figuras homotéticas y otros diálogos con el brócoli romanesco. "Entre" el dibujo artístico y el técnico.
Authors: Jové Glòria , Olivera Olga 
Published: October 2014

En este artículo mostramos como aprender, enseñar y comunicarnos a través del arte, especialmente del arte contemporáneo en la formación de profesionales de la educación, nos lleva a concretar propuestas docentes creativas para que los profesionales de la educación seamos capaces de imaginar formas distintas de enseñar y aprender. Nuestros años de experiencia y de conocimiento sobre ella nos llevan a cuestionar: ¿Por qué en el mundo de la educación están tan arraigados algunos modelos docentes?¿Por qué se habla tanto de la necesidad del cambio y cuesta tanto su implementación y sobretodo su continuidad? Y por tanto ¿de qué manera podemos articular los espacios formativos para deconstruir y reconstruir estos modelos que llevamos tan entroncados? Para ello proponemos una actividad a partir de un brócoli romanescu. Los estudiantes tienen que dibujar el trozo de brócoli y dialogar con él como personas que quieren ser maestros y profesores y que forman parte de una comunidad. Es necesario también concretar las relaciones a que les lleva el diálogo con el brócoli y el mundo de la educación. Uno de estos diálogos permite a una profesora de dibujo de secundaria a establecer una hibridación entre dibujo técnico / dibujo artístico y romper con una histórica oposición binaria o dicotómica entre ambos. Mostramos posibilidades en este espacio intermedio y por lo tanto permite ver la materia de dibujo técnico desde otra perspectiva. Palabras clave- aprender a través del arte, formación docente, dibujo artístico, dibujo técnico, hibridación, docencia creativahttp://dx.doi.org/10.7203/eari.5.3521
Personal Variables as Differentiating Factors in the Services of Salaam Police Center
Authors: WARADJE DENNIS B. , MALONZO ELIZABETH M. 
Published: October 2014

The PNP is currently facing challenges and problems in the delivery of Police services in the community. This study is a descriptive survey to determine and compare the level of community satisfaction on the services of Salaam Police Center in Davao City. Muslim communities were just moderately satisfied of the Salaam Police Center services to the Mosque (church) and School based activities and Organization of Council of Imams. There was a significant difference in the level of community satisfaction to the Salaam Police services when they were grouped by age, civil status, secular educational attainment and ethnic affiliation. This implies that younger respondents, 21- 30 years old, manifest higher level of satisfaction than those who are 51 years old and above. Those who are single, and in college, are more satisfied than those who are married and in high school. They have the same level of satisfaction when grouped by Islamic educational attainment.In view of the findings an enhancement program for the Salaam Police Center is developed for implementation to the activities of the Mosque and Madrasa base, Organization of Council of Imams and Muslim NGOs, and the Continuous Information and Education campaign.Keywords: Social science, community satisfaction, Salaam Police Center, Davao City
Compliance with International Law on Trafficking by the Philippines: A Critical Analysis
Authors: VEDAÑA MARIESTHER B. 
Published: October 2014

Trafficking in persons refers to any kind of human exploitation with or withoutconsent of the victim. Prior to the UN’s Trafficking Protocol in 2000 almost allof the States did not have a particular law specifically defining and addressingtrafficking in persons. The paper aims to analyze how the Philippines has compliedwith the provisions of the UN Trafficking Protocol through the discussion of itsprovisions and the minimum standards stated in the related provisions of the USTrafficking Victims Protection Act (TVPA) and the pertinent provisions of R.A.No. 9208 Philippine Law on Trafficking. The effectivity of the implementation ofthe Philippine Trafficking law as shown in the reports of the Inter-Agency CouncilAgainst Trafficking in Persons (IACAT) in the Philippines and the reports of theUS State Department shall also be discussed. The researcher analyzed descriptivelythe legal documents and data gathered. The results showed the Philippines has not been fully complying to the provisions and standards set forth in the UNTrafficking Protocol and the TVPA. It is therefore, necessary for the Philippinesto show not just efforts to eradicate trafficking but also take further action on the same.Keywords: Trafficking in persons laws, UN Trafficking Protocol, content analysis,Philippines
Convergence of Fraternities and Sororities: Finale of Campus Violence in a Public Asian University
Authors: SORIA JIMMY R. , JARAMILLA ALDRIN S. , DELA ROSA JOSELITO D. 
Published: October 2014

Good governance addresses an issue on campus peace and security. Everybody isaware of rising incidence of campus violence and hooliganism brought by warring fraternities. The stakeholders especially the parents are much distressed over thiscampus disorder that they are in situations as to find an antidote in addressing thisconcern. This study was conducted to determine the potentials of these Greekletteredsocieties that can be tapped as partnersin institutional development.Theresearchersemployeddescriptivemethod using qualitativedesign. Documents were analyzed, and guide instrument was used to reach out key informants who were subjected to focus group discussion. Findings show that fraternities existed inthe campus, though operate underground because of lack of juridical identity. Therate of incidence on physical assault attributed to fraternities was high comparedwith the occurrence of a similar crime after they were recognized. Students gave varied explanations in joining these fraternities. Some favorably acknowledged itsimportance while others considered it as just another predicament. Their existencein the academic community is an intervening mechanism and developmentstrategy. It has to cast away that impression of being ambiguous in nature, insteadprove to be an instrument of promoting campus peace in the university.Keywords: Social science, fraternities, sororities, thematic analysis, descriptive design,Philippines
Fears, Aspirations, and Hopes: A Springboard of Life for Domestically Abused Children
Authors: Andacao Arvin , Lugo Maria Gloria , Pajo Danilo 
Published: October 2014

The youth are the hope of the native land. Unfortunately, children in homes where there is domestic violence are more likely to be abused or neglected. This is one of the most prevalent and rampant quandaries in the society which requires critical attention of a victim. Thus, a study was conducted to determine the demographic profile, forge fears, aspirations and hopes as voices of domestically abused children and produce programs to possibly heal the victims. Guided by the qualitative research design and interpretative sociology orientation, the phenomenological approach was primarily used in the study. Information was generated by the researchers through in-depth interview, key informant interview, and focus group discussion utilizing self-made questionnaire. The findings revealed that 90 percent of informants were minor age, all female victims and suffered domestic abuse. The results on the fears, aspirations, and hopes as springboard of their existence showed positive indication with the victims to fulfill their desires. However, government and other support groups were hunted. Hence, the study concludes that aspirations and hopes were constant goal of the victims and their fears were poignant blueprint to their opening or preference of destiny. Further, this study identified various programs needed by the victims to completely attain their aspirations of life.Keywordsâ€” Â Social Sciences, domestic abuse, fears, aspirations, hopes, qualitative design, phenomenological approach, Philippines
Modes and emergent time scales of embayed beach dynamics
Authors: Ratliff Katherine M. , Murray A. Brad 
Published: October 2014

AbstractIn this study, we use a simple numerical model (the Coastline Evolution Model) to explore alongshore transport‐driven shoreline dynamics within generalized embayed beaches (neglecting cross‐shore effects). Using principal component analysis (PCA), we identify two primary orthogonal modes of shoreline behavior that describe shoreline variation about its unchanging mean position: the rotation mode, which has been previously identified and describes changes in the mean shoreline orientation, and a newly identified breathing mode, which represents changes in shoreline curvature. Wavelet analysis of the PCA mode time series reveals characteristic time scales of these modes (typically years to decades) that emerge within even a statistically constant white‐noise wave climate (without changes in external forcing), suggesting that these time scales can arise from internal system dynamics. The time scales of both modes increase linearly with shoreface depth, suggesting that the embayed beach sediment transport dynamics exhibit a diffusive scaling.
Characterization of seasonal and longitudinal variability of EEJ in the Indian region
Authors: Phani Chandrasekhar N. , Arora Kusumita , Nagarajan Nandini 
Published: October 2014

AbstractThis paper presents the seasonal and longitudinal variability of the equatorial electrojet (EEJ) based on geomagnetic variation data from two electrojet stations in the northern Indian Ocean at a longitudinal separation of ~15°: i.e., at 77°E and at 93°E. One complete year of data is used (i.e., from November 2011 to October 2012) at the two longitudes and compared with the climatological model of the equatorial electrojet (EEJM‐2.0). The results of our analysis show that (i) the monthly averaged hourly values of EEJ strength at 77°E and 93°E are overall in agreement with global characteristics of EEJ with significant departures over the year of study, (ii) the monthly average hourly daytime values at Campbell Bay and Vencode show poor correlation (r < 0.7) for 5 out of 10 months, (iii) comparison of observed EEJ strength at respective longitudes and the current densities derived from EEJM‐2.0 show overall agreement with significant differences for monthly mean hourly daytime values at respective longitudes, and (iv) day‐to‐day variability in noontime EEJ amplitudes between the two longitudes is >10 nT, >20 nT for 30% of quiet days, sorted by planetary index (Kp) <1 and <2. This variability is reflected in monthly average values (V) mechanisms for persistent differences in EEJ on day‐to‐day basis are sought from perturbation of westward ion drifts by neutral winds caused by the upward propagation of gravity waves from troposphere/stratosphere into the mesosphere. These mechanisms have been identified theoretically and experimentally. The four‐wave structure of ionospheric current densities obtained by EEJM‐2.0 and other contemporary models closely resembles atmospheric tidal signatures and has a common origin. The magnitude and persistence of these differences, at short spatial scales (15°), are significant observation. These effects are reflected in the monthly and seasonal signatures of EEJ and contribute to the contemporary models.
Cooling magma model for deep volcanic long‐period earthquakes
Authors: Aso Naofumi , Tsai Victor C. 
Published: October 2014

AbstractDeep long‐period events (DLP events) or deep low‐frequency earthquakes (deep LFEs) are deep earthquakes that radiate low‐frequency seismic waves. While tectonic deep LFEs on plate boundaries are thought to be slip events, there have only been a limited number of studies on the physical mechanism of volcanic DLP events around the Moho (crust‐mantle boundary) beneath volcanoes. One reasonable mechanism capable of producing their initial fractures is the effect of thermal stresses. Since ascending magma diapirs tend to stagnate near the Moho, where the vertical gradient of density is high, we suggest that cooling magma may play an important role in volcanic DLP event occurrence. Assuming an initial thermal perturbation of 400°C within a tabular magma of half width 41 m or a cylindrical magma of 74 m radius, thermal strain rates within the intruded magma are higher than tectonic strain rates of ~ 10−14 s−1 and produce a total strain of 2 × 10−4. Shear brittle fractures generated by the thermal strains can produce a compensated linear vector dipole mechanism as observed and potentially also explain the harmonic seismic waveforms from an excited resonance. In our model, we predict correlation between the particular shape of the cluster and the orientation of focal mechanisms, which is partly supported by observations of Aso and Ide (2014). To assess the generality of our cooling magma model as a cause for volcanic DLP events, additional work on relocations and focal mechanisms is essential and would be important to understanding the physical processes causing volcanic DLP events.
The pronounced seasonality of global groundwater recharge
Authors: Jasechko Scott , Birks S. Jean , Gleeson Tom , Wada Yoshihide , Fawcett Peter J. , Sharp Zachary D. , McDonnell Jeffrey J. , Welker Jeffrey M. 
Published: October 2014

AbstractGroundwater recharged by meteoric water supports human life by providing two billion people with drinking water and by supplying 40% of cropland irrigation. While annual groundwater recharge rates are reported in many studies, fewer studies have explicitly quantified intra‐annual (i.e., seasonal) differences in groundwater recharge. Understanding seasonal differences in the fraction of precipitation that recharges aquifers is important for predicting annual recharge groundwater rates under changing seasonal precipitation and evapotranspiration regimes in a warming climate, for accurately interpreting isotopic proxies in paleoclimate records, and for understanding linkages between ecosystem productivity and groundwater recharge. Here we determine seasonal differences in the groundwater recharge ratio, defined here as the ratio of groundwater recharge to precipitation, at 54 globally distributed locations on the basis of 18O/16O and 2H/1H ratios in precipitation and groundwater. Our analysis shows that arid and temperate climates have wintertime groundwater recharge ratios that are consistently higher than summertime groundwater recharge ratios, while tropical groundwater recharge ratios are at a maximum during the wet season. The isotope‐based recharge ratio seasonality is consistent with monthly outputs from a global hydrological model (PCR‐GLOBWB) for most, but not all locations. The pronounced seasonality in groundwater recharge ratios shown in this study signifies that, from the point of view of predicting future groundwater recharge rates, a unit change in winter (temperate and arid regions) or wet season (tropics) precipitation will result in a greater change to the annual groundwater recharge rate than the same unit change to summer or dry season precipitation.