bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Enhanced Thermoelectric Performance of Synthetic Tetrahedrites.
Authors: Heo Jaeseok , Laurita Geneva , Muir Sean , Subramanian M. A. , Keszler Douglas A. 
Published: May 2014

AbstractCu10M2Sb4S13 (M: Mn, Fe, Co, Ni, Zn) and the solid solution Cu12‐xMnxSb4S13 (0 ≤ x ≤ 2) are prepared by solid state reaction of stoichiometric mixtures of the elements (evacuated silica tube, 450 °C, 3 weeks) followed by pressure sintering for further pellet compaction (450 °C, 10 MPa).
ChemInform Abstract: Catalytic Enantioselective Synthesis of α‐Substituted Secondary Allylic Alcohols from Terminal Alkynes and Aldehydes via Vinylaluminum Reagents.
Authors: Kumar Ravindra , Kawasaki Hiroki , Harada Toshiro 
Published: May 2014

AbstractThe use of Me2AlH is essential in the Ni‐catalyzed hydroalumination step to generate reactivity‐tuned vinylaluminum reagents not able to reduce the aldehyde starting material.
ChemInform Abstract: Introducing the Diels—Alder Reactivity of 2‐Furanmethanethiol with Selected Maleic Acid Derivatives.
Authors: Schwan Adrian L. , Shkoor Mohanad Gh. , Nikoloska Irena 
Published: May 2014

AbstractSurprisingly, a clean Diels—Alder reaction occurs between 2‐furylmethanethiol (I) and maleic acid in Et2O furnishing exclusively the exo‐adduct (III) in excellent yield.
ChemInform Abstract: Enantioselective Synthesis and Application to the Allylic Imidate Rearrangement of Amine‐Coordinated Palladacycle Catalysts of Cobalt Sandwich Complexes.
Authors: Cassar Doyle J. , Ilyashenko Gennadiy , Ismail Muhammad , Woods James , Hughes David L. , Richards Christopher J. 
Published: May 2014

AbstractThe enantioselective palladation of amine substrates followed by enantioselective transcyclopalladation enables the synthesis of ferrocene‐based phosphapalladacycles with good enantiomeric excess.
ChemInform Abstract: Electrochemical Synthesis of the Aryl α‐Ketoesters from Acetophenones Mediated by KI.
Authors: Zhang Zhenlei , Su Jihu , Zha Zhenggen , Wang Zhiyong 
Published: May 2014

AbstractThis anodic oxidation of acetophenones in the presence of methanol or ethanol not only provides a simple approach to α‐ketoester derivatives, but also delivers a new method to construct a C‐O bond by anodic oxidation.
ChemInform Abstract: Utilization of Common Ligands for the Ruthenium‐Catalyzed Amination of Alcohols.
Authors: Baumann Wolfgang , Spannenberg Anke , Pfeffer Jan , Haas Thomas , Koeckritz Angela , Martin Andreas , Deutsch Jens 
Published: May 2014

AbstractThe catalytic suitability of a new ruthenium complex for the one‐step conversion of primary and secondary alcohols into amines is investigated.
ChemInform Abstract: A Non‐Infringing Route for Enantioselective Synthesis of Antiepileptic Agent Lacosamide.
Authors: Wadavrao Sachin B. , Narikimalli Ashritha , Narsaiah A. Venkat 
Published: May 2014

AbstractThe target compound is synthesized in 8 steps and 29% overall yield starting from acrylic acid.
ChemInform Abstract: En route to Multicatalysis: Kinetic Resolution of trans‐Cycloalkane‐1,2‐diols via Oxidative Esterification.
Authors: Hofmann Christine , Schuler Soeren M. M. , Wende Raffael C. , Schreiner Peter R. 
Published: May 2014

AbstractA variety of aldehydes are activated by 4‐nitrobenzoic acid and oxidized by TEMPO to afford the mixed anhydrides followed by the enantioselective reaction with cycloalkane‐1,2‐diols leading to the optically enriched diols and esters.
ChemInform Abstract: Direct Route to 1,3‐Diketones by Palladium‐Catalyzed Carbonylative Coupling of Aryl Halides with Acetylacetone.
Authors: Korsager Signe , Nielsen Dennis U. , Taaning Rolf H. , Lindhardt Anders T. , Skrydstrup Troels 
Published: May 2014

AbstractThe selective route to diketones and triketones involves a three‐component Pd‐catalyzed carbonylative α‐arylation with high functional group tolerance.
ChemInform Abstract: Synthesis of 3‐Substituted 2‐Aminonaphtho[2,3‐b]furan‐4,9‐diones from 2‐Hydroxy‐1,4‐naphthoquinone and Nitroalkenes.
Authors: Zanwar Manoj R. , Kavala Veerababurao , Gawande Sachin D. , Kuo Chun‐Wei , Kuo Ting‐Shen , Chen Mei‐Ling , He Chiu‐Hui , Yao Ching‐Fa 
Published: May 2014

AbstractA convenient method for the synthesis of naphthofuran diones (III) through condensation of 2‐hydroxy‐1,4‐naphthoquinone with nitrostyrenes under aqueous conditions is reported.
ChemInform Abstract: Unconventional Stereoselective One‐Pot Synthesis of Knoevenagel‐Type Indoles via in situ Condensation of Iminium Salts with Active Methylene Reagents.
Authors: Ranise Angelo , Lucchesini Francesco , Caviglia Matteo , Alfei Silvana , Spallarossa Andrea , Caneva Chiara 
Published: May 2014

AbstractEt3N‐mediated condensation of preformed or in situ generated indole iminium salts with active methylene reagents provides stereoselectively Knoevenagel‐type indoles in moderate to good yields.
ChemInform Abstract: Metal‐Free, Acid‐Promoted Synthesis of Imidazole Derivatives via a Multicomponent Reaction.
Authors: Chen Chung‐Yu , Hu Wan‐Ping , Yan Pi‐Cheng , Senadi Gopal Chandru , Wang Jeh‐Jeng 
Published: May 2014

AbstractThe synthesized compounds are screened with respect to fluorescence and UV absorption, and compound (XIII) showed the furthest red‐shifted emission and absorption.
ChemInform Abstract: Furo[2,3‐c]pyrans from a Vinyl Sulfone Modified Methyl 2,6‐O‐Anhydro‐α‐D‐hexopyranoside: An Experimental and Theoretical Investigation.
Authors: Manna Chinmoy , Sahu Debashis , Ganguly Bishwajit , Pathak Tanmaya 
Published: May 2014

AbstractTitle vinyl sulfone (III) is applied as Michael acceptor for carbon, nitrogen, and oxygen nucleophiles for the first time.
ChemInform Abstract: Synthesis of Diversely Substituted Indoloquinolinones via Pd(II)/Cu(II)‐Mediated Oxidative C—C Bond Formation and I(III)‐Mediated C—N Bond Formation.
Authors: Zhang Xiang , Zhang‐Negrerie Daisy , Deng Jun , Du Yunfei , Zhao Kang 
Published: May 2014

AbstractAn alternative route to prepare synthetically and biologically interesting indoloquinolinones is presented.
ChemInform Abstract: Acridone—Pterocarpan Conjugate: A Hybrid Molecular Probe for Recognition of Nucleic Acids.
Authors: Chattopadhyay Shital K. , Maitra Ratnava , Kundu Indranil , Jana Manoranjan , Mandal Sushil K. , Khuda‐Bukhsh Anisur Rahman 
Published: May 2014

AbstractMolecules containing acridone and pterocarpan structural subunits are synthesized and their capability of binding duplex DNA is demonstrated.
ChemInform Abstract: Synthesis of Fused Thiazolo[3,2‐a]pyrimidinones: N‐Aryl‐2‐chloroacetamides as Doubly Electrophilic Building Blocks.
Authors: Janardhan Banothu , Srinivas Basavoju , Rajitha Bavantula , Crooks Peter A. 
Published: May 2014

AbstractTwo facile procedures for the cyclocondensation of substrate (I) with the building blocks (II) or (IV) to produce fused thiazolopyrimidinone derivatives are developed.
ChemInform Abstract: Olefin Isomerization and Hydrosilylation Catalysis by Lewis Acidic Organofluorophosphonium Salts.
Authors: Perez Manuel , Hounjet Lindsay J. , Caputo Christopher B. , Dobrovetsky Roman , Stephan Douglas W. 
Published: May 2014

AbstractIn addition to the hydrosilylation reaction, the catalyst can also be used for the isomerization of alkenes under similar conditions (without a silane), e.g. 1‐hexene is isomerized to an E/Z mixture of 2‐hexene along with small amounts of polymerization products.
ChemInform Abstract: Silver‐Mediated Oxidative C—H/P—H Functionalization: An Efficient Route for the Synthesis of Benzo[b]phosphole Oxides.
Authors: Chen Yun‐Rong , Duan Wei‐Liang 
Published: May 2014

AbstractA new and efficient method for the synthesis of benzo[b]phosphole oxides via a Ag‐mediated oxidative C—H/P—H functionalization reaction of disubstituted phosphine oxides with internal alkynes is described.
ChemInform Abstract: Syntheses of α‐Stannylated and α‐Iodinated Enamides via Molybdenum‐Catalyzed Hydrostannation.
Authors: Maity Pulakesh , Klos Manuel R. , Kazmaier Uli 
Published: May 2014

AbstractA novel molybdenum catalyst is used for the regioselective α‐hydrostannation of ynamides (I) yielding E‐configurated enamides (III) which undergo tin‐iodine exchange to give iodinated enamides (IV).
ChemInform Abstract: Hydroxymethylated Phyllobilins: A Puzzling New Feature of the Dioxobilin Branch of Chlorophyll Breakdown.
Authors: Suessenbacher Iris , Christ Bastien , Hoertensteiner Stefan , Kraeutler Bernhard 
Published: May 2014

AbstractA structural investigation of dioxobilin‐type chlorophyll catabolites (DCC) in the methylesterase16 mutant of Arbidopsis thaliana is reported.
ChemInform Abstract: The Chemistry and Biological Potential of Azetidin‐2‐ones.
Authors: Arya Nikhilesh , Jagdale Archana Y. , Patil Tushar A. , Yeramwar Shradha S. , Holikatti Sidharam S. , Dwivedi Jaya , Shishoo Chamanlal J. , Jain Kishor S. 
Published: May 2014

AbstractReview: 198 refs.
ChemInform Abstract: The Applications of Binuclear Metallohydrolases in Medicine: Recent Advances in the Design and Development of Novel Drug Leads for Purple Acid Phosphatases, Metallo‐β‐lactamases and Arginases
Authors: McGeary Ross P. , Schenk Gerhard , Guddat Luke W. 
Published: May 2014

AbstractReview: 129 refs.
A quasi‐2D and quasi‐steady hydraulic model for physical habitat simulations
Authors: Choi Sung‐Uk , Jung Sanghwa , Kim Seung Ki 
Published: May 2014

AbstractThis study presents a new hydraulic model for simulating the physical habitat of a river. The model is based on the quasi‐steady assumption that the flow is steady, but the channel morphology changes during the computational time step. The model is also capable of simulating flow distribution in the lateral direction, making the model quasi‐two‐dimensional. The physical habitat simulations are carried out for a reach including a bend in the Dal River in Korea. Zacco platypus is used as the target fish. The habitat suitability index model for Zacco platypus, based on field monitoring, is used for the habitat simulation. The hydraulic model simulates morphological changes caused by a flood and the result is compared with the two‐dimensional model. Simulation results obtained using the developed model compares favorably to calculations obtained using the two‐dimensional model. Distributions of the habitat suitability index are provided for various flows by the present model. It is found that the morphological change by the flood increases the habitat suitability significantly by decreasing the flow depth and increasing the velocity in the study reach. In addition, the time change of the weighted usable area based on the mobile‐bed computation is given, indicating that the flood decreases the habitat suitability seriously. Copyright © 2014 John Wiley & Sons, Ltd.
Statistical models for shear strength of RC beam‐column joints using machine‐learning techniques
Authors: Jeon Jong‐Su , Shafieezadeh Abdollah , DesRoches Reginald 
Published: May 2014

SUMMARYThis paper proposes a new set of probabilistic joint shear strength models using the conventional multiple linear regression method, and advanced machine‐learning methods of multivariate adaptive regression splines (MARS) and symbolic regression (SR). In order to achieve high‐fidelity regression models with reduced model errors and bias, this study constructs extensive experimental databases for reinforced and unreinforced concrete joints by collecting existing beam‐column joint subassemblage tests from multiple sources. Various influential parameters that affect joint shear strength such as material properties, design parameters, and joint configuration are investigated through tests of statistical significance. After performing a set of regression analyses, the comparison of simulation results indicates that MARS approach is the best estimation method. Moreover, the accuracy of analytical predictions of the derived MARS model is compared with that of existing joint shear strength relationships. The comparison results show that the proposed model is more accurate compared to existing relationships. This joint shear strength prediction model can be readily implemented into joint response models for evaluation of earthquake performance and inelastic responses of building frames. Copyright © 2014 John Wiley & Sons, Ltd.
The Distribution of Uncertainty: Evidence from the VIX Options Market
Authors: Völkert Clemens 
Published: May 2014

AbstractThis article investigates the informational content implied in the risk‐neutral distribution of the VIX, a leading barometer of economic uncertainty. We extract the risk‐neutral distribution from VIX option prices over the sample period from 2006 to 2011 using a non‐parametric approach. We analyze the time‐series behavior of the option‐implied moments and assess whether the information implied in the risk‐neutral distribution has predictive power. The risk‐neutral distribution considerably changed shape during the financial crisis. Furthermore, risk‐neutral moments contain useful information with respect to the likelihood of upward jumps in volatility. Consistent with investors disliking high levels of economic uncertainty, we find that the overall shape of the estimated volatility pricing kernel is increasing. For certain periods, there is a puzzling U‐shape. The behavior of the volatility pricing kernel over time reveals that the financial crisis has affected investors’ attitudes towards risk. © 2014 Wiley Periodicals, Inc. Jrl Fut Mark 35:597–624, 2015
Dimethylarsinic acid (DMAV) changed the expressions of proliferative related factors and secretion of inflammatory cytokines in rat bladder
Authors: Lin Zhang , Shengnan Liu , Fei Wang , Yingli Song , Qingshan Sun , Wei Sheng , Shuhua Xi. , Guifan Sun 
Published: May 2014

ABSTRACTDimethylarsinic acid (DMAV), the major urinary metabolite of inorganic arsenic, is a urinary bladder carcinogen and bladder tumor promoter in adult rats. Increased urothelial cellular proliferation has been considered as an earlier phenotype in DMAV‐induced bladder carcinogenesis. The present study examined the ultrastructural changes of bladder epithelial cells and expressions of proliferation factors, as well as the secretion of inflammatory cytokines in rats exposed to DMAV for 10 weeks by transmission electron microscopy (TEM), qRT‐PCR, immunohistochemical staining and ELISA methods. The results showed that DMAV administered in the drinking water produced urothelial cytotoxicity and ultrastructural changes in rats. PCNA, cyclin D1 and COX‐2 mRNA expressions and immunoreactivities were elevated in bladder urothelium. In addition, 200 ppm DMAV treatment increased the transforming growth factor‐beta 1 (TGF‐β1) secretion and decreased tumor necrosis factor‐alpha (TNF)‐α level in the urine of rats. These data suggest that chronic inflammation, bladder epithelium lesions and proliferation might be the basic process of the chronic toxicity effects in DMAV‐treated rats. Copyright © 2014 John Wiley & Sons, Ltd.
An investigation of common crosslinking agents on the stability of electrospun collagen scaffolds
Authors: Huang Gloria Portocarrero , Shanmugasundaram Shobana , Masih Pallavi , Pandya Deep , Amara Suwah , Collins George , Arinzeh Treena Livingston 
Published: May 2014

AbstractElectrospinning is a widely used processing method to form fibrous tissue engineering scaffolds that mimic the structural features of the native extracellular matrix. Electrospun fibers made of collagen have been sought because it is a natural structural protein that supports cell attachment and growth. Yet, conventional solvents used to electrospin collagen can result in the loss of hydrolytic stability and fiber morphology of the scaffold. This study evaluated the effect of commonly used synthetic and natural crosslinking agents, genipin, glutaraldehyde, N‐(3‐dimethylaminopropyl)‐N′‐ethylcarbodiimide hydrochloride (EDC), and EDC with N‐hydroxysulfosuccinimide (EDC–NHS), on electrospun collagen. Crosslinked collagen scaffolds were assessed for structural integrity in an in vitro immersion study for up to 3 months. Their cytocompatibility was evaluated by human mesenchymal stem cell morphology and proliferation. Our results showed that dimensional stability and cytocompatibility of crosslinked electrospun collagen scaffolds are dependent on the type of crosslinking agent used. Collagen scaffolds treated with EDC and EDC–NHS were structurally stable and retained fiber structure for up to 3 months and were cytocompatible. Therefore, EDC and EDC–NHS are favorable crosslinking agents for electrospun collagen that can be utilized in tissue engineering applications. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 762–771, 2015.
The crosslinking degree controls the mechanical, rheological, and swelling properties of hyaluronic acid microparticles
Authors: Shimojo Andréa Arruda Martins , Pires Aline Mara Barbosa , Lichy Rafael , Rodrigues Ana Amélia , Santana Maria Helena Andrade 
Published: May 2014

AbstractViscosupplements, used for treating joint and cartilage diseases, restore the rheological properties of synovial fluid, regulate joint homeostasis and act as scaffolds for cell growth and tissue regeneration. Most viscosupplements are hydrogels composed of hyaluronic acid (HA) microparticles suspended in fluid HA. These microparticles are crosslinked with chemicals to assure their stability against enzyme degradation and to prolong the action of the viscosupplement. However, the crosslinking also modifies the mechanical, swelling and rheological properties of the HA microparticle hydrogels, with consequences on the effectiveness of the application. The aim of this study is to correlate the crosslinking degree (CD) with these properties to achieve modulation of HA/DVS microparticles through CD control. Because divinyl sulfone (DVS) is the usual crosslinker of HA in viscosupplements, we examined the effects of CD by preparing HA microparticles at 1:1, 2:1, 3:1, and 5:1 HA/DVS mass ratios. The CD was calculated from inductively coupled plasma spectrometry data. HA microparticles were previously sized to a mean diameter of 87.5 µm. Higher CD increased the viscoelasticity and the extrusion force and reduced the swelling of the HA microparticle hydrogels, which also showed Newtonian pseudoplastic behavior and were classified as covalent weak. The hydrogels were not cytotoxic to fibroblasts according to an MTT (3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5‐diphenyltetrazolium bromide) assay. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 730–737, 2015.
Comparison of surface modification chemistries in mouse, porcine, and human islets
Authors: SoRelle Jeffrey A. , Kanak Mazhar A. , Itoh Takeshi , Horton Joshua M. , Naziruddin Bashoo , Kane Robert R. 
Published: May 2014

AbstractBeta cell replacement therapy, the transplantation of isolated pancreatic islets by intraportal infusion, offers patients with brittle type 1 diabetes blood glucose regulation with a minimally invasive technique. Chemical modification of islets prior to transplantation, providing a nanothin barrier that potentially includes active protective compounds, has been proposed as a strategy to minimize the inflammatory and immune reactions that often significantly limit graft function and duration. Chemical modification also has the potential to allow the use of alternative sources of islets, such as porcine islets, for transplantation. This investigation compared three orthogonal covalent islet modification techniques across three species (human, porcine, and murine), using multiple measures to determine biocompatibility and effectiveness. All three conjugation chemistries were well tolerated, and the overall efficiency, gross uniformity, and stability of the surface modifications were dependent upon the conjugation chemistry as well as the islet source (human, porcine, or murine). Notably, the reductive modification of surface disulfides was shown to afford intense and long‐lasting modification of human islets. This study demonstrates that murine, human, and porcine islets tolerate a variety of covalent modifications, that these modifications are relatively stable, and that the murine islet model may not be predictive for some chemical contexts. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 869–877, 2015.
Biodegradable polyester‐based microcarriers with modified surface tailored for tissue engineering
Authors: Privalova A. , Markvicheva E. , Sevrin Ch. , Drozdova M. , Kottgen C. , Gilbert B. , Ortiz M. , Grandfils Ch. 
Published: May 2014

AbstractMicrocarriers have been proposed in tissue engineering, namely for bone, cartilage, skin, vascular, and central nervous system. Although polyester‐based microcarriers have been already used for this purpose, their surface properties should be improved to provide better cell growth. The goal of this study was to prepare microbeads based on poly(d,l‐lactide) acid, poly(l‐lactide) acid, and to study cell behavior (adhesion, spreading, growth, and proliferation) in function of microbead topography and surface chemistry. To improve L‐929 fibroblasts adhesion, microbead surface has been modified with three polycations: chitosan, poly(2‐dimethylamino ethylmethacrylate) (PDMAEMA), or chitosan‐g‐oligolactide copolymer (chit‐g‐OLA). Although modification of the microbead surface with chitosan and PDMAEMA was performed through physical adsorption on the previously prepared microbeads, chit‐g‐OLA copolymer was introduced directly during microbead processing. This simple approach (1) bypass the use of an emulsifier (polyvinyl alcohol, PVA); (2) avoid surface “contamination” with PVA molecules limiting a control of the surface characteristics. In vitro study of the growth of mouse fibroblasts on the microbeads showed that both surface topography and chemistry affected cell attachment, spreading, and proliferation. Cultivation of L‐929 fibroblasts for 7 days resulted in the formation of a 3D cell‐scaffold network. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 939–948, 2015.
Search for Breast Cancer Biomarkers in Fractionated Serum Samples by Protein Profiling With SELDI‐TOF MS
Authors: Opstal‐van Winden Annemieke W.J. , Beijnen Jos H. , Loof Arnoud , van Heerde Waander L. , Vermeulen Roel , Peeters Petra H.M. , van Gils Carla H. 
Published: May 2014

BackgroundMany high‐abundant acute phase reactants have been previously detected as potential breast cancer biomar‐kers. However, they are unlikely to be specific for breast cancer. Cancer‐specific biomarkers are thought to be among the lower abundant proteins.MethodsWe aimed to detect lower abundant discriminating proteins by performing serum fractionation by strong anion exchange chromatography preceding protein profiling with SELDI‐TOF MS. In a pilot study, we tested the different fractions resulting from fractionation, on several array types. Fraction 3 on IMAC30 and Fraction 6 on Q10 yielded the most discriminative proteins and were used for serum protein profiling of 73 incident breast cancer cases and 73 matched controls.ResultsEight peaks showed statistically significantly different intensities between cases and controls (P⧁0.05), and had less than 10% chance to be a false‐positive finding. Seven of these were tentatively identified as apolipoprotein C‐II (m/z 8,909), oxidized apolipoprotein C‐II (m/z 8,925), apolipoprotein C‐III (m/z 8,746), fragment of coagulation factor XIIIa (m/z 3,959), heterodimer of apolipoprotein A‐I and apolipoprotein A‐II (m/z 45,435), hemoglobin B‐chain (m/z 15,915), and post‐translational modified hemoglobin (m/z 15,346).ConclusionBy extensive serum fractionation, we detected many more proteins than in previous studies without fractionation. However, discriminating proteins were still high abundant. Results indicate that either lower abundant proteins are less distinctive, or more rigorous fractionation and selective protein depletion, or a more sensitive assay, are needed to detect lower abundant discriminative proteins.