bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impacts of muscle-specific force-velocity properties on predictions of mouse muscle function during locomotion
Authors: Charles James P. , Kissane Roger W. P. , Askew Graham N. 
Published: July 2024

Introduction: The accuracy of musculoskeletal models and simulations as methods for predicting muscle functional outputs is always improving. However, even the most complex models contain various assumptions and simplifications in how muscle force generation is simulated. One common example is the application of a generalised (“generic”) force-velocity relationship, derived from a limited data set to each muscle within a model, uniformly across all muscles irrespective of whether those muscles have “fast” or “slow” contractile properties.Methods: Using a previously built and validated musculoskeletal model and simulation of trotting in the mouse hindlimb, this work examines the predicted functional impact of applying muscle-specific force-velocity properties to typically fast (extensor digitorum longus; EDL) and slow-contracting (soleus; SOL) muscles.Results: Using “real” data led to EDL producing more positive work and acting significantly more spring-like, and soleus producing more negative work and acting more brake-like in function compared to muscles modelled using “generic” force-velocity data. Extrapolating these force-velocity properties to other muscles considered “fast” or “slow” also substantially impacted their predicted function. Importantly, this also further impacted EDL and SOL function beyond that seen when changing only their properties alone, to a point where they show an improved match to ex vivo experimental data.Discussion: These data suggest that further improvements to how musculoskeletal models and simulations predict muscle function should include the use of different values defining their force-velocity relationship depending on their fibre-type composition.
Enhanced secretion of promyogenic exosomes by quiescent muscle cells
Authors: Devan Prabhavathy , Ghosh Ananga , Rao T. Pallavi , Raychaudhuri Swasti , Adicherla Harikrishna , Devanshi Himadri , Kshetrapal Pallavi , Dhawan Jyotsna 
Published: July 2024

Signaling interactions are important during skeletal muscle regeneration, where muscle cells in distinct states (quiescent, reactivated, proliferating and differentiated) must coordinate their response to injury. Here, we probed the role of secreted small extracellular vesicles (sEV/exosomes) using a culture model of physiologically relevant cell states seen in muscle regeneration. Unexpectedly, G0 myoblasts exhibited enhanced secretion of sEV (∼150 nm) displaying exosome markers (Alix, TSG101, flotillin-1, and CD9), and increased expression of Kibra, a regulator of exosome biogenesis. Perturbation of Kibra levels confirmed a role in controlling sEV secretion rates. Purified sEVs displayed a common exosome marker-enriched proteome in all muscle cell states, as well as state-specific proteins. Exosomes derived from G0 cells showed an antioxidant signature, and were most strongly internalized by differentiated myotubes. Functionally, donor exosomes from all muscle cell states could activate an integrated Wnt reporter in target cells, but only G0-derived exosomes could induce myogenic differentiation in proliferating cells. Taken together, we provide evidence that quiescence in muscle cells is accompanied by enhanced secretion of exosomes with distinct uptake, cargo and signal activating features. Our study suggests the novel possibility that quiescent muscle stem cells in vivo may play a previously under-appreciated signaling role during muscle homeostasis.
Metabolic characteristics of different phenotypes in reproductive-aged women with polycystic ovary syndrome
Authors: Wen Xinling , Wang Li , Bai E. 
Published: July 2024

ObjectivePolycystic ovary syndrome (PCOS) is an endocrine metabolic disorder in reproductive-aged women. The study was designed to investigate the metabolic characteristics of different phenotypes in women with PCOS of reproductive age.MethodsA total of 442 women with PCOS were recruited in this cross-sectional study. According to different phenotypes, all women were divided into three groups: the chronic ovulatory dysfunction and hyperandrogenism group (OD-HA group, n = 138), the chronic ovulatory dysfunction and polycystic ovarian morphology group (OD-PCOM group, n = 161), and the hyperandrogenism and polycystic ovarian morphology group (HA-PCOM group, n = 143). The metabolic risk factors and prevalence rates of metabolic disorders among the three groups were compared.ResultsThe body mass index (BMI), waist circumference, and waist-to-hip ratio (WHR) of women from the OD-HA group and HA-PCOM group were significantly higher than those of women from the OD-PCOM group (p &lt; 0.05). The serum insulin concentration and homeostasis model assessment of insulin resistance (HOMA IR) at 2 h and 3 h after oral glucose powder in women from the OD-HA group and HA-PCOM group were significantly higher than those from the OD-PCOM group (p &lt; 0.05). The serum total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) in women from the OD-HA group and HA-PCOM group were significantly higher than those in women from the OD-PCOM group (p &lt; 0.05). The prevalence rates of impaired glucose tolerance (IGT), type 2 diabetes mellitus (T2DM), insulin resistance (IR), metabolic syndrome (MS), nonalcoholic fatty liver disease (NAFLD), and dyslipidemia of women with PCOS were 17.9%, 3.6%, 58.4%, 29.4%, 46.6%, and 43.4%, respectively. The prevalence rates of IGT, IR, MS, NAFLD, and dyslipidemia of women in the OD-HA group and HA-PCOM group were significantly higher than those of women in the OD-PCOM group (p &lt; 0.05). T concentration (&gt;1.67 nmol/L) and Ferriman–Gallwey (F–G) score (&gt;3) significantly increased the risk of metabolic disorders in women with PCOS (p &lt; 0.05).ConclusionThe phenotypes of OD-HA and HA-PCOM in women with PCOS were vulnerable to metabolic disorders compared to OD-PCOM. Thus, the metabolic disorders in women with PCOS especially those with the HA phenotype should be paid more attention in order to reduce long-term complications.
Bamboo charcoal application altered the mineralization process of soil organic carbon in different succession stages of karst forest land
Authors: Hu Lening , Liu Xuehui , Xie Yaqi , Zeng Yicheng , Ou Huiping , Yu Yuefeng , He Tieguang 
Published: July 2024

Introduction: As a soil amendment, Bamboo charcoal helps to contributes to the improvement of soil carbon sequestration, but its effect on the accumulation and transformation of different soil organic carbon in soil of karst forests is not clear.Methods: The research focused on three distinct forest land succession stages: virgin forest, secondary forest, and planted forest. A 60-day indoor constant temperature culture experiment was conducted, applying bamboo charcoal to the soil of the three forest lands at four different addition ratios: 0%, 1.0%, 2.0%, and 4.0%. The analysis aimed to study the characteristics of SOC mineralization, different carbon fractions of organic carbon, and soil enzyme activity.Results: The findings revealed that bamboo charcoal application led to an increase in the organic carbon (SOC) content within the three forest soils. Moreover, the organic carbon content showed an increase corresponding to the increased proportion of bamboo charcoal, with the highest SOC content observed in the planted forest land with 4.0% bamboo charcoal. The overall performance of the C0/SOC value in the three forest soils was ranked as follows: planted forest &lt; secondary forest &lt; virgin forest (C0: the mineralization potential of soil organic carbon). In both planted and secondary forest soils, the C0/SOC value increased after the application of bamboo charcoal. However, in the virgin forest soil, the application of 1.0% and 4.0% bamboo charcoal reduced the C0/SOC value, while the application of 2.0% bamboo charcoal increased the C0/SOC value. Particularly the C0/SOC value of the planted forest soil without bamboo charcoal was the smallest at 0.047, whereas that in the virgin forest soil with 2.0% bamboo charcoal had the largest value at 0.161.Discussion: Herein, appropriate human intervention can enhance the carbon sequestration potential of forest soil, in different succession stages within the karst area. However, the external application of bamboo charcoal does not significantly improve the carbon sequestration potential in the planted and secondary forest. Notably, applying a higher proportion (4.0%) of bamboo charcoal can enhance the organic carbon sequestration potential, particularly in the virgin forest soil, representing the climax community of forest succession.
Mangroves trend and their impact on surface temperature in Al-Wajh Lagoon: a study aligned with Saudi Arabia's vision 2030
Authors: Al-huqail Asma A. , Islam Zubairul , Al-Harbi Hanan F. 
Published: July 2024

Mangrove ecosystems are vital to arid environments like Saudi Arabia, offering crucial ecological services and enhancing biodiversity. This study investigates the spatial distribution and temporal dynamics of mangrove coverage in the Al Wajh lagoon area, crucial for crafting effective conservation and management strategies. Employing high-resolution Landsat and Sentinel imagery, the Normalized Difference Vegetation Index (NDVI) and Land Surface Temperature (LST) were analysed across 35 mangrove clusters. By 2023, mangroves covered approximately 24.5 km2. Kendall Tau-b Correlation Coefficients confirmed a significant positive trend. The study further explored the relationship between NDVI and surface temperature, revealing an inverse correlation with slope values ranging from −4.03 to −44.1, suggesting that increased mangrove coverage significantly contributes to local cooling, thereby underscoring the climate regulation benefits of mangrove conservation. This positive change in NDVI post-2020 is directly attributable to the conservation efforts embedded within the Red Sea Project, Vision 2030, development phases, demonstrating the critical role of designated conservation zones in mitigating the environmental impacts of large-scale development projects. The findings underscore the need for targeted policies to protect and expand mangrove habitats as part of broader environmental sustainability goals in the region.
A DWI-based hypoxia model shows robustness in an external prostatectomy cohort
Authors: Fernandez Salamanca M. , Hompland T. , Deręgowska-Cylke M. , Van der Poel H. , Bekers E. , Guimaraes M. A. S. , Lyng H. , Van der Heide U. A. , Schoots I. G. , Van Houdt P. J. 
Published: July 2024

IntroductionProstate cancer hypoxia is a negative prognostic biomarker. A promising MRI-based tool to assess hypoxia is the ‘Consumption and Supply based Hypoxia’ (CSH) model based on diffusion-weighted imaging (DWI). The aim of the study was to validate the association between the CSH hypoxia fraction (HFDWI) with pathological Grade Group (pGG) and pathological T-staging (pTstage) in an external prostatectomy cohort.MethodsApparent diffusion coefficient (ADC) and fractional blood volume (fBV) maps were assessed from DWI data from 291 prostatectomies and combined by the CSH model. HFDWI was calculated for each lesion after median scaling of ADC and fBV to address differences in acquisition and analysis between centers. The absolute HFDWI values and the associations of HFDWI between pGG &lt; 3 versus ≥ 3, and pTstage = 2 versus = 3 in the Netherlands Cancer Institute (NKI) cohort were compared to the obtained by original cohort (Oslo cohort). Statistical T- and Mann-Whitney tests (p&lt;0.05) were performed. Pearson correlation was determined between HFDWI and individual pGG groups.ResultsThe HFDWI showed comparable absolute values and similar metric performance as in the original published cohort. Higher HFDWI values were observed for higher pGG (Oslo: 0.27; NKI: 0.24) compared to lower pGG (Oslo: 0.11; NKI: 0.17). Similar results were obtained for pTstage. Furthermore, HFDWI demonstrated a significant positive correlation with pGG groups 1-5 (ρ = 0.41, p&lt;0.001).ConclusionThe CSH model exhibited sufficient robustness in the external cohort, suggesting a plausible reflection of true hypoxia and enabling the use of the HFDWI metric for further research into prostate cancer and hypoxia.
THE USE OF ECO-SAVING TECHNOLOGIES IN THE CONSTRUCTION OF URBAN INFRASTRUCTURE
Authors: Каменский М.Н. , Голубина Е.Н. 
Published: July 2024

В работе показана возможность прокладывания инженерных коммуникаций к объектам городской инфраструктуры бестраншейным способом с целью уменьшения негативного воздействия на окружающую среду. Также предложена компактная схема грунтопрокалывающей установки.
The paper shows the possibility of laying engineering communications to urban infrastructure facilities in a trenchless way in order to reduce the negative impact on the environment. A compact scheme of a ground-piercing installation is also proposed.
NITRIC ACID PROCESSING OF LARGE-TONNAGE MAGNESILICATE WASTE ASBESTOO CONCENTRATION
Authors: Габдуллин А.Н. , Вайтнер В.В. 
Published: July 2024

Статья посвящена азотнокислотной малоотходной технологии переработки магнийсиликатного сырья техногенного происхождения, образующегося при обогащении хризотилового асбеста. Эта порода (серпентинит) содержит примерно по 35–45 % оксидов магния и кремния, а также оксиды железа, алюминия, никеля (II), хрома (III), марганца. В ходе технологического процесса образуется чистый нитрат магния, за счет термического гидролиза которого выделяются оксид магния и регенерируется азотная кислота. Из кремнеземистого остатка получен высокодисперсный диоксид кремния. В основе всего метода лежит замкнутость технологического процесса по основным применяемым реактивам: азотной кислоте, оксиду магния, нитрату магния.
The article is devoted to nitric acid low-waste technology for processing magnesium silicate raw materials of technogenic origin, formed during the enrichment of chrysotile asbestos. This rock (serpentinite) contains approximately 35–45% each of magnesium and silicon oxides, as well as oxides of iron, aluminum, nickel (II), chromium (III), and manganese. During the process, pure magnesium nitrate is formed, due to thermal hydrolysis of which magnesium oxide is released and nitric acid is regenerated. Highly dispersed silicon dioxide is obtained from the siliceous residue. The entire method is based on technological closure in the main reagents used: nitric acid, magnesium oxide, magnesium nitrate.
COMPARATIVE ANALYSIS OF NICKEL-CONTAINING COMPOUNDS FOR THE PREPARATION OF AQUA-AMMONIA NICKEL COMPLEXES
Authors: Добрыднев С.В. , Александрова О.А. 
Published: July 2024

Приведены данные по оценке никельсодержащего сырья и выбору подходящих реагентов для получения аммиачно-карбонатных растворов комплексов никеля. Обоснован выбор использования гидроксида никеля в процессе растворения в аммиачно-карбонатной смеси.
Data on the evaluation of nickel-containing raw materials and the selection of suitable reagents for the production of ammonium-carbonate solutions of nickel complexes are presented. The choice of using nickel hydroxide in the process of dissolution in an ammonia-carbonate mixture is justified.
STUDYING THE ADSORPTORY PROPERTIES OF MESOPOROUS SILICA GEL DOPED WITH TERBIUM AND MODIFIED WITH SILVER
Authors: Токранов А.А. , Овчинникова Д.В. , Токранова Е.О. , Шафигулин Р.В. , Буланова А.В. 
Published: July 2024

Методом обращенной газовой хроматографии изучены адсорбционные свойства мезопристого силикагеля, допированного требием, модифицированного серебром (Tb-Ag/MC). Физико-химические характеристики катализатора изучены методами сканирующей электронной микроскопии, рентгенофлуоресцентного и рентгенодифракционного анализа, масс-спектрометрии с индуктивно связанной плазмой. Показано, что полученный катализатор является эффективным и селективным по гексену при гидрировании смеси гексин-1/гексен-1.
The adsorption properties of mesoprist silica gel doped with trebium and modified with silver (Tb-Ag/MC) were studied using inverse gas chromatography. The physicochemical characteristics of the catalyst were studied by scanning electron microscopy, X-ray fluorescence and X-ray diffraction analysis, and inductively coupled plasma mass spectrometry. It was shown that the resulting catalyst is effective and selective for hexene in the hydrogenation of a hexine-1/hexene-1 mixture.
INVESTIGATION OF CHROMATOGRAPHIC BEHAVIOR OF FLAVONOIDS BY RP HPLC
Authors: Разницына В.М. , Шафигулин Р.В. , Куркин В.А. , Буланова А.В. 
Published: July 2024

Изучена сорбция некоторых флавоноидов (рутина, (+)-катехин гидрата, гесперидина, цинарозида, кверцитрина) на сверхсшитом полистироле из водно-ацетонитрильных растворов методом ОФ ВЭЖХ. Оценено влияние добавок бромидных имидазолиевых ионных жидкостей на эффективность и селективность разделения.
The sorption of some flavonoids (rutin, (+)-catechin hydrate, hesperidin, cynaroside, quercitrin) on hyper-cross-linked polystyrene from aqueous-acetonitrile solutions by RP HPLC was studied. The effect of additives of bromide imidazolium ionic liquids on the efficiency and selectivity of separation was estimated.
STRENGTHENING INVENTIONAL ACTIVITY AS A WAY TO DEVELOP AND IMPLEMENT «GREEN TECHNOLOGIES»
Authors: Афанасьев С.В. , Кобзарь Т.С. , Сердюкова С.В. 
Published: July 2024

Рассмотрены проблемы активизации инновационной работы в сфере промышленной экологии на предприятиях и в организациях Самарской области по реализации важнейших национальных проектов. К их числу можно отнести загрязнение атмосферного воздуха выбросами вредных веществ и формирование по указанной причине фотохимического агрессивного смога, эмиссию в атмосферу огромных количеств парниковых газов и связанное с этим изменение климата на нашей планете, загрязнение Волжского бассейна стоками промышленных предприятий, обусловливающих цветение воды и засоление окружающих территорий, накопление крупнотоннажных отходов добычи полезных ископаемых в виде нефтешламовых амбаров и другие. Практически по всем перечисленным общенациональным проектам предложены и апробированы инновационные решения, защищённые патентами. Отмечены факторы, препятствующие подъёму изобретательской деятельности в Самарском регионе. Среди них: несовершенство действующего законодательства в области патентного права, отсутствие материального стимулирования НИР и НИОКР, существующий барьер между промышленным производством и наукой, нехватка квалифицированных специалистов и учёных в области промышленной экологии.
The problems of activating innovative work in the field of industrial ecology at enterprises and organizations of the Samara region for the implementation of the most important national projects are considered. These include the pollution of the atmospheric air by emissions of harmful substances and the formation of photochemical aggressive smog for this reason, the emission of huge 31 amounts of greenhouse gases into the atmosphere and the associated climate change on our planet, the pollution of the Volga basin by industrial effluents that cause water bloom and salinization of surrounding areas, accumulation of large-tonnage waste from mining in the form of oil sludge pits, and others. The reason for the current environmental situation in the country is the low innovation climate in the field of industrial ecology. Innovative solutions protected by patents have been proposed and tested for almost all of the listed national projects. The factors that hinder the rise of inventive activity in the Samara region are noted. Among them - the imperfection of the current legislation in the field of patent law, the lack of material incentives for research and development and R&D, the existing barrier between industrial production and science, the lack of qualified specialists and scientists in the field of industrial ecology.
THE COMBINATION OF TLC AND FT-IR SPECTROMETRY METHODS IN THE ANALYSIS OF MATERIALS
Authors: Редькин Н.А. , Лобачев А.Л. 
Published: July 2024

Для исследования материалов можно использовать сочетание методов ТСХ и ИК-Фурье спектрометрии. Основной сложностью такого сочетания является извлечение компонентов с пластины и дальнейшая запись спектра. В данной работе рассматриваются варианты перенесения пробы с ТСХ пластины для записи ИК спектров.
Сombination of TLC and FT-IR spectrometry methods can be used for materials study. The main difficulty of this combination is the extraction of components from the wafer and further recording of the spectrum. This work discusses options for transferring a sample from a TLC plate to record IR spectra.
STUDY OF THE INFLUENCE OF SEA WAVE HEIGHT ON THE EFFECTIVENESS OF OIL SPILL DISPERSANT USING MESOSCALE MODELING
Authors: Куряшов Д.А. , Юлдашев Р.И. , Фаткуллина Д.И. , Латыпова Е.А. 
Published: July 2024

Диспергенты широко используются в качестве метода ЛАРН для того, чтобы разбить пятно нефти на мелкие капли и рассеять его в воде. Однако эффективность этих реагентов может меняться в зависимости от условий окружающей среды, таких как высота морских волн. В данной работе изучается влияние этого параметра на эффективность применения диспергентов. Также описывается применение мезомасштабного моделирования для имитации разлива нефти при различных высотах морских волн.
Dispersants are commonly used for oil spills response by breaking up the oil into smaller droplets that can disperse more easily. However, the effectiveness of dispersants may vary depending on environmental conditions, such as sea wave height. In this study the impact of sea wave height on the efficiency of dispersant application is thoroughly investigated. The use of mesoscale modeling is also described to simulate oil spills at various heights of sea waves.
The leadership phenomenon in public administration
Authors: Сизганова Е.Ю. , Ашин А.А. , Кайдашова А.К. 
Published: July 2024

Исследование феномена лидерства в государственном управлении является актуальным научным направлением. Профессиональные компетенции лидера, его мастерство и личностные качества играют все более серьезную роль в повышении эффективности государственного управления в современных условиях. Авторы обращаются к анализу данного явления в контексте современной ситуации взаимодействия общества и государства. Сопоставляются различные оценки функции лидерства в управлении. Предлагаются составляющие модели лидера, способного решать актуальные задачи для ускоренного развития нашей страны. Вопросы, рассматриваемые в статье, могут заинтересовать руководителей органов государственной власти, а также исследователей в области лидерства и менеджмента.
The study of the leadership phenomenon in public administration is an actual scientific direction. The professional competence of a leader, his skills and personal qualities play an increasingly important role in improving the efficiency of public administration in modern conditions. The authors turn to the analysis of this phenomenon in the context of the current situation of interaction between society and the state. Different assessments of the leadership function in management arecompared. Components of the model of a leader capable of solving urgent problems for the accelerated development of our country are proposed. The issues discussed in the article may be of interest to heads of state authorities, as well as researchers in the field of leadership and management.