bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of a multi-micronutrient-fortified beverage, with and without sugar, on growth and cognition in South African schoolchildren: a randomised, double-blind, controlled intervention
Authors: Taljaard Christine , Covic Namukolo M. , van Graan Averalda E. , Kruger Herculina S. , Smuts Cornelius M. , Baumgartner Jeannine , Kvalsvig Jane D. , Wright Hattie H. , van Stuijvenberg Martha E. , Jerling Johann C. 
Published: July 2013

Little is known about the effects of combined micronutrient and sugar consumption on growth and cognition. In the present study, we investigated the effects of micronutrients and sugar, alone and in combination, in a beverage on growth and cognition in schoolchildren. In a 2 × 2 factorial design, children (n414, 6–11 years) were randomly allocated to consume beverages containing (1) micronutrients with sugar, (2) micronutrients with a non-nutritive sweetener, (3) no micronutrients with sugar or (4) no micronutrients with a non-nutritive sweetener for 8·5 months. Growth was assessed and cognition was tested using the Kaufman Assessment Battery for Children version II (KABC-II) subtests and the Hopkins Verbal Learning Test (HVLT). Micronutrients decreased the OR for Fe deficiency at the endpoint (OR 0·19; 95 % CI 0·07, 0·53). Micronutrients increased KABC Atlantis (intervention effect: 0·76; 95 % CI 0·10, 1·42) and HVLT Discrimination Index (1·00; 95 % CI 0·01, 2·00) scores. Sugar increased KABC Atlantis (0·71; 95 % CI 0·05, 1·37) and Rover (0·72; 95 % CI 0·08, 1·35) scores and HVLT Recall 3 (0·94; 95 % CI 0·15, 1·72). Significant micronutrient × sugar interaction effects on the Atlantis, Number recall, Rover and Discrimination Index scores indicated that micronutrients and sugar in combination attenuated the beneficial effects of micronutrients or sugar alone. Micronutrients or sugar alone had a lowering effect on weight-for-agez-scores relative to controls (micronutrients − 0·08; 95 % CI − 0·15, − 0·01; sugar − 0·07; 95 % CI − 0·14, − 0·002), but in combination, this effect was attenuated. The beverages with micronutrients or added sugar alone had a beneficial effect on cognition, which was attenuated when provided in combination.
Connectedness properties of the set where the iterates of an entire function are bounded
Authors: OSBORNE JOHN 
Published: July 2013

AbstractWe investigate some connectedness properties of the set of points K(f) where the iterates of an entire function f are bounded. We describe a class of transcendental entire functions for which K(f) is totally disconnected if and only if each component of K(f) containing a critical point is aperiodic. Moreover we show that, for such functions, if K(f) is disconnected then it has uncountably many components. We give examples of functions for which K(f) is totally disconnected and we use quasiconformal surgery to construct a function for which K(f) has a component with empty interior that is not a singleton.
A review of cognitive therapy in acute medical settings. Part II: Strategies and complexities
Authors: Levin Tomer T. , White Craig A. , Bialer Philip , Charlson Robert W. , Kissane David W. 
Published: July 2013

AbstractObjective:Cognitive therapy (CT) has considerable utility for psychosomatic medicine (PM) in acute medical settings but, to date, no such cohesive adaptation has been developed. Part I delineated a CT model for acute medical settings focusing on assessment and formulation. In Part II, we review how CT can be applied to common PM clinical challenges. A pragmatic approach is helpful because this review targets PM trainees and educators.Methods:Narrative review is used to discuss the application of CT strategies to common challenges in acute medical settings. Treatment complexities and limitations associated with the PM setting are detailed. Exemplary dialogues are used to model techniques.Result:We present CT approaches to eight common scenarios: (1) distressed or hopeless patients; (2) patients expressing pivotal distorted cognitions/images; (3) patients who catastrophize; (4) patients who benefit from distraction and activation strategies; (5) panic and anxiety; (6) suicidal patients; (7) patients who are stuck and helpless; (8) inhibited patients. Limitations are discussed.Significance of results:A CT informed PM assessment, formulation and early intervention with specific techniques offers a novel integrative framework for psychotherapy with the acutely medically ill. Future efforts should focus on dissemination, education of fellows and building research efficacy data.
Low temperature delays timing and enhances the cost of nitrogen fixation in the unicellular cyanobacterium Cyanothece
Authors: Brauer Verena S , Stomp Maayke , Rosso Camillo , van Beusekom Sebastiaan A M , Emmerich Barbara , Stal Lucas J , Huisman Jef 
Published: July 2013

Abstract
Marine nitrogen-fixing cyanobacteria are largely confined to the tropical and subtropical ocean. It has been argued that their global biogeographical distribution reflects the physiologically feasible temperature range at which they can perform nitrogen fixation. In this study we refine this line of argumentation for the globally important group of unicellular diazotrophic cyanobacteria, and pose the following two hypotheses: (i) nitrogen fixation is limited by nitrogenase activity at low temperature and by oxygen diffusion at high temperature, which is manifested by a shift from strong to weak temperature dependence of nitrogenase activity, and (ii) high respiration rates are required to maintain very low levels of oxygen for nitrogenase, which results in enhanced respiratory cost per molecule of fixed nitrogen at low temperature. We tested these hypotheses in laboratory experiments with the unicellular cyanobacterium Cyanothece sp. BG043511. In line with the first hypothesis, the specific growth rate increased strongly with temperature from 18 to 30 °C, but leveled off at higher temperature under nitrogen-fixing conditions. As predicted by the second hypothesis, the respiratory cost of nitrogen fixation and also the cellular C:N ratio rose sharply at temperatures below 21 °C. In addition, we found that low temperature caused a strong delay in the onset of the nocturnal nitrogenase activity, which shortened the remaining nighttime available for nitrogen fixation. Together, these results point at a lower temperature limit for unicellular nitrogen-fixing cyanobacteria, which offers an explanation for their (sub)tropical distribution and suggests expansion of their biogeographical range by global warming.
Multifactorial diversity sustains microbial community stability
Authors: Erkus Oylum , de Jager Victor C L , Spus Maciej , van Alen-Boerrigter Ingrid J , van Rijswijck Irma M H , Hazelwood Lucie , Janssen Patrick W M , van Hijum Sacha A F T , Kleerebezem Michiel , Smid Eddy J 
Published: July 2013

Abstract
Maintenance of a high degree of biodiversity in homogeneous environments is poorly understood. A complex cheese starter culture with a long history of use was characterized as a model system to study simple microbial communities. Eight distinct genetic lineages were identified, encompassing two species: Lactococcus lactis and Leuconostoc mesenteroides. The genetic lineages were found to be collections of strains with variable plasmid content and phage sensitivities. Kill-the-winner hypothesis explaining the suppression of the fittest strains by density-dependent phage predation was operational at the strain level. This prevents the eradication of entire genetic lineages from the community during propagation regimes (back-slopping), stabilizing the genetic heterogeneity in the starter culture against environmental uncertainty.
Optically Induced Thermal Gradients for Protein Characterization in Nanolitre-scale Samples in Microfluidic Devices
Authors: Sagar D. M. , Aoudjane Samir , Gaudet Matthieu , Aeppli Gabriel , Dalby Paul A. 
Published: July 2013

AbstractProteins are the most vital biological functional units in every living cell. Measurement of protein stability is central to understanding their structure, function and role in diseases. While proteins are also sought as therapeutic agents, they can cause diseases by misfolding and aggregation in vivo. Here we demonstrate a novel method to measure protein stability and denaturation kinetics, on unprecedented timescales, through optically-induced heating of nanolitre samples in microfluidic capillaries. We obtain protein denaturation kinetics as a function of temperature and accurate thermodynamic stability data, from a snapshot experiment on a single sample. We also report the first experimental characterization of optical heating in controlled microcapillary flow, verified by computational fluid dynamics modelling. Our results demonstrate that we now have the engineering science in hand to design integrated all-optical microfluidic chips for a diverse range of applications including in-vitro DNA amplification, healthcare diagnostics and flow chemistry.
Chemical suppression of an oncogenic splicing variant of AIMP2 induces tumour regression
Authors: Lee Hee Sook , Kim Dae Gyu , Oh Young Sun , Kwon Nam Hoon , Lee Jin Young , Kim Doyeun , Park Song-Hwa , Song Jong-Hwan , Lee Sunkyung , Han Jung Min , Park Bum-Joon , Lee Jongkook , Kim Sunghoon 
Published: July 2013

AIMP2 (aminoacyl-tRNA synthetase-interacting multifunctional protein 2) is a potent tumour suppressor that induces apoptosis in response to various oncogenic signals. AIMP2-DX2, an exon2-deleted splicing variant of AIMP2, is up-regulated in lung cancer and competitively suppresses the pro-apoptotic activity of AIMP2, resulting in tumorigenesis. In the present study we report that BC-DXI01, a synthetic compound, specifically reduces the cellular levels of AIMP2-DX2 through selective degradation of the AIMP2-DX2 mRNA transcript. We found that BC-DXI01-mediated cell death positively correlates with AIMP2-DX2 expression in the lung cancer cell lines tested. Administration of BC-DXI01 in a AIMP2-DX2-driven tumour xenograft mice model led to reduced tumour sizes and volumes of up to 60% in comparison with vehicle-treated mice group, consistent with decreases in AIMP2-DX2 transcript and protein levels. Taken together, our findings suggest that tumorigenic activity of AIMP2-DX2 can be controlled by the small chemical BC-DXI01, which can selectively suppress the AIMP2-DX2 mRNA transcript.
Direct Field and Laboratory Evidence that a Combination of Egg and Larval Predation Controls Recruitment of Invasive Common Carp in Many Lakes of the Upper Mississippi River Basin
Authors: Silbernagel Justin J. , Sorensen Peter W. 
Published: July 2013

AbstractField and laboratory experiments tested the hypothesis that recruitment of the invasive Common Carp Cyprinus carpio is often controlled by the feeding activity of egg and larval predators in interconnected lakes of the upper Mississippi River basin. The survival of naturally spawned carp eggs was monitored in a seemingly typical lake by sampling the abundance of such eggs in spawning areas and in the diets of fish caught at these locations. Over 95% of the carp eggs found attached to spawning substrate disappeared within 4 d of spawning, at the same time that large numbers of eggs were found in the stomachs of Bluegills Lepomis macrochirus. Egg predation closely paralleled but lagged egg disappearance. Concurrent laboratory studies showed that carp eggs hatched after 4.75 d at lake temperatures, demonstrating that most (but perhaps not all) of the eggs had been eaten by egg predators prior to hatching. A second laboratory experiment found that Bluegills readily find and consume carp larvae while Black Bullheads Ameiurus melas do not, suggesting that predation on larvae contributes to carp recruitment. These data, together with previous studies of the survival of carp eggs placed into lakes and the distribution of young carp relative to various species of native fish, add strong support to the hypothesis that the recruitment of carp in interconnected lakes of the upper Mississippi River basin is often controlled by native fish predators.
Impacts of Exotic Rainbow Trout on Habitat Use by Native Juvenile Salmonid Species at an Early Invasive Stage
Authors: Thibault Isabel , Dodson Julian 
Published: July 2013

AbstractThe detrimental impact of introduced Rainbow Trout Oncorhynchus mykiss on native communities has been well documented around the world. Previous studies have focused on streams where the invasion has been successful and the species is fully established. In eastern Quebec, the invasion of Rainbow Trout is an ongoing process and, for now, there are few established populations. The presence of two native salmonids in these rivers, Atlantic Salmon Salmo salar and Brook Trout Salvelinus fontinalis, implies a risk of competition for habitat, despite the relatively low density of the Rainbow Trout populations, as all three species are known to use similar resources. In order to evaluate the strength of the interaction between the invading fish and the native species, we sampled nine rivers (five with Rainbow Trout and four free of Rainbow Trout) and characterized the habitat used by the three salmonids at the juvenile stage. River‐scale analysis revealed that in invaded rivers, Rainbow Trout were associated with habitats characterized by closer proximity to the shoreline and by increasing shoreline cover. Estimates of habitat niche overlap integrating depth, water velocity, and substrate size revealed that niche overlap between Brook Trout and Atlantic Salmon significantly increased in the presence of Rainbow Trout. Furthermore, the two indigenous species preferred full cover in the absence of Rainbow Trout but in the presence of Rainbow Trout, which also preferred full cover, the indigenous species moved to more open habitats. Rainbow Trout showed a high growth rate, despite a size disadvantage at the beginning of the growing season, as compared with Atlantic Salmon and Brook Trout. It thus appears that even at an early stage of invasion, when its density is still low, Rainbow Trout significantly impact native salmonids.
mRMRe: an R package for parallelized mRMR ensemble feature selection
Authors: De Jay Nicolas , Papillon-Cavanagh Simon , Olsen Catharina , El-Hachem Nehme , Bontempi Gianluca , Haibe-Kains Benjamin 
Published: July 2013

Abstract
Motivation: Feature selection is one of the main challenges in analyzing high-throughput genomic data. Minimum redundancy maximum relevance (mRMR) is a particularly fast feature selection method for finding a set of both relevant and complementary features. Here we describe the mRMRe R package, in which the mRMR technique is extended by using an ensemble approach to better explore the feature space and build more robust predictors. To deal with the computational complexity of the ensemble approach, the main functions of the package are implemented and parallelized in C using the openMP Application Programming Interface.
Results: Our ensemble mRMR implementations outperform the classical mRMR approach in terms of prediction accuracy. They identify genes more relevant to the biological context and may lead to richer biological interpretations. The parallelized functions included in the package show significant gains in terms of run-time speed when compared with previously released packages.
Availability: The R package mRMRe is available on Comprehensive R Archive Network and is provided open source under the Artistic-2.0 License. The code used to generate all the results reported in this application note is available from Supplementary File 1.
Contact: bhaibeka@ircm.qc.ca
Supplementary information: Supplementary data are available at Bioinformatics online.
Relationship between Intraoperative Mean Arterial Pressure and Clinical Outcomes after Noncardiac Surgery
Authors: Walsh Michael , Devereaux Philip J. , Garg Amit X. , Kurz Andrea , Turan Alparslan , Rodseth Reitze N. , Cywinski Jacek , Thabane Lehana , Sessler Daniel I. 
Published: July 2013

Abstract

Background:
Intraoperative hypotension may contribute to postoperative acute kidney injury (AKI) and myocardial injury, but what blood pressures are unsafe is unclear. The authors evaluated the association between the intraoperative mean arterial pressure (MAP) and the risk of AKI and myocardial injury.

Methods:
The authors obtained perioperative data for 33,330 noncardiac surgeries at the Cleveland Clinic, Ohio. The authors evaluated the association between intraoperative MAP from less than 55 to 75 mmHg and postoperative AKI and myocardial injury to determine the threshold of MAP where risk is increased. The authors then evaluated the association between the duration below this threshold and their outcomes adjusting for potential confounding variables.

Results:
AKI and myocardial injury developed in 2,478 (7.4%) and 770 (2.3%) surgeries, respectively. The MAP threshold where the risk for both outcomes increased was less than 55 mmHg. Compared with never developing a MAP less than 55 mmHg, those with a MAP less than 55 mmHg for 1–5, 6–10, 11–20, and more than 20 min had graded increases in their risk of the two outcomes (AKI: 1.18 [95% CI, 1.06–1.31], 1.19 [1.03–1.39], 1.32 [1.11–1.56], and 1.51 [1.24–1.84], respectively; myocardial injury 1.30 [1.06–1.5], 1.47 [1.13–1.93], 1.79 [1.33–2.39], and 1.82 [1.31–2.55], respectively].

Conclusions:
Even short durations of an intraoperative MAP less than 55 mmHg are associated with AKI and myocardial injury. Randomized trials are required to determine whether outcomes improve with interventions that maintain an intraoperative MAP of at least 55 mmHg.
Intrathecal Gabapentin to Treat Chronic Intractable Noncancer Pain
Authors: Rauck Richard , Coffey Robert J. , Schultz David M. , Wallace Mark S. , Webster Lynn R. , McCarville Sally E. , Grigsby Eric J. , Page Linda M. 
Published: July 2013

Abstract

Background:
Oral gabapentin is approved as an anticonvulsant medication and to treat postherpetic neuralgia. Its nonopioid properties and presumed spinal site of analgesic action made the study on intrathecal gabapentin attractive to establish the minimum effective dose for a later, pivotal trial.

Methods:
The authors examined the safety and efficacy of intrathecal gabapentin in a randomized, blinded, placebo-controlled, multicenter trial in a heterogeneous cohort of candidates with chronic pain for intrathecal drug therapy.

Results:
Patients (N = 170) were randomized to receive continuous intrathecal gabapentin (0 [placebo], 1, 6, or 30 mg/day) during 22 days of blinded treatment after implantation of a permanent drug delivery system. The highest dose, 30 mg/day, was selected to maintain a safety margin below the 100-mg/day dose that was explored in a phase 1 study. The authors found no statistically significant difference in the primary outcome measure, which was the numerical pain rating scale and response rate after 3 weeks, for any dose versus placebo. Physical functioning, quality of life, and emotional functioning also revealed no differences. Small, nonsignificant changes occurred in opioid medication use. The most frequent device-related adverse events were transient postimplant (lumbar puncture) headache, pain, and nausea. The most frequent gabapentin-related adverse events were nausea, somnolence, headache, dizziness, fatigue, and peripheral edema.

Conclusion:
Twenty-two days of intrathecal gabapentin did not demonstrate statistically significant or clinically meaningful analgesic effects. The study sponsor has no current plans for further studies. Drug-related adverse events were similar to those for oral gabapentin. Most device-related adverse events resulted from the implant surgery or anesthesia.
The effect of labour earnings on post retirement income
Authors: Adami Roberta , Gough Orla , Theophilopoulou Angeliki 
Published: July 2013

PurposeThe purpose of this paper is to investigate how changes in the distribution of pre retirement labour earnings affect post‐retirement income in the UK.Design/methodology/approachThe authors estimate a PROBIT model and perform a counterfactual simulation to assess the effects of changes in the earnings distributions on pensions in the UK. The paper uses data from the British Household Panel Survey (BHPS).FindingsThe distribution of labour earnings before retirement plays a considerable role in the pension distribution of current retirees, particularly for low and medium incomes in the period 1991‐2007 for the UK. Improvements in Social Security have lifted many out of poverty; however there is still a gender gap as it is found that the current system of public and private schemes has not substantially improved pension income dispersion among women. On the other hand, changes in labour earning distributions have benefited more poor female pensioners than male.Originality/valueThe paper uses BHPS data, which is a longitudinal panel of survey questions made to UK households between 1991 and 2007. The level of detail of such data allows the study of the complete distributions of pre and post retirement income rather than focussing only on some measures of dispersion.
Trade performances and technology in the enlarged European Union
Authors: Antimiani Alessandro , Costantini Valeria 
Published: July 2013

PurposeThe purpose of this paper is to analyse the role of the enlargement process of the European Union as a factor fostering international competitiveness of EU Member States. The paper argues that the economic integration process has reduced the technological gap between old and new EU Member States, and this pattern of technological innovation can partially explain the strong impulse on the export dynamics of European countries.Design/methodology/approachThe paper builds an augmented gravity model by including the role of technological innovation, proxied by the stock of knowledge at the sector level. The authors gather together information on patents applied to international offices and bilateral export flows available from COMTRADE dataset.FindingsBy using a dynamic panel data estimator the authors find three main empirical evidences. First, the enlargement process has produced an overall larger positive impact on export flows for new Members than for old ones, and more importantly that sectors with the higher technological content have received the strongest impulse. Second, the augmented gravity model allows shaping the crucial role of technological innovation in fostering export competitiveness. Third, this impact seems to be stronger for old EU Member States than for new ones.Research limitations/implicationsThe major limitation concerns time span adopted in this work. By expanding the dataset to further years it could be possible to better disentangle the effects also related to the new wave of the EU enlargement.Social implicationsThe policy implication derived is that the more the new EU Members catch up technologically as a result of the integration process, the more they will benefit in terms of economic development.Originality/valueThe major originality of this paper is the construction of an augmented gravity model by including the role of technological innovation, applied to distinguished manufacturing sectors in a dynamic panel setting.