bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wading into the undeniable
Authors: Keep Stephanie , Reid Ann , Branch Glenn 
Published: April 2015

Abstract
In his review of Bill Nye’s Undeniable, Nicholas Wade proposes a “treaty” to defuse controversies over the teaching of evolution: describing evolution as a theory ambiguously—as a well-established scientific theory to supporters of evolution education, but as “just a theory” to opponents of evolution education. On inspection, Wade’s proposal misidentifies the focus of the creationist objection to evolution, distorts the nature of science, and involves a blatant equivocation. Rather than equivocating on the term theory à la Wade, teachers ought to focus on ensuring that students understand not only the important theories in the field of evolutionary biology but also what a theory in science is and isn’t.
Gene- and stem cell-based therapeutics for cartilage regeneration and repair
Authors: Tang Ying , Wang Bing 
Published: April 2015

AbstractCell-based regeneration of damaged or diseased articular cartilage still faces significant clinical challenge due to inadequate environmental regulation of stem cell proliferation and chondrogenic differentiation. The role of insulin-like growth factor in critical steps of human bone marrow-derived mesenchymal stem cell chondrogenesis has potential in optimizing the therapeutic use of mesenchymal stem cells in cartilage disorders. In addition to the previously described benefits of recombinant adeno-associated viral vector for in vivo gene therapy, demonstrated by Frisch and colleagues, such vector is also a safe and efficient delivery system for the genetic modification of human bone marrow-derived mesenchymal stem cells via ex vivo insulin-like growth factor 1 gene transfer, so that implanted mesenchymal stem cells continuously release a therapeutic level of insulin-like growth factor 1 to achieve sustained mesenchymal stem cell chondrogenesis for cartilage regeneration.
The relationship between LAPTM4B polymorphisms and cancer risk in Chinese Han population: a meta-analysis
Authors: Xia Ling-Zi , Yin Zhi-Hua , Ren Yang-Wu , Shen Li , Wu Wei , Li Xue-Lian , Guan Peng , Zhou Bao-Sen 
Published: April 2015

Abstract
LAPTM4B is a newly cloned gene that shows an active role in many solid tumors progression in substantial researches, mainly through the autophage function. Accumulated studies have been conducted to determine the association of LAPTM4B polymorphism with cancer risk. While the results are inconsistent, we conducted the meta-analysis to determine the strength of the relationship. Results showed that allele*2 carriers exhibited a significantly increased risk of cancer development with comparison to allele*1 homozygote (for *1/2, OR = 1.55, 95% CI 1.367-1.758; for *2/2, OR = 2.093, 95%CI 1.666-2.629; for *1/2 + *2/2, OR = 1.806, 95%CI 1.527-2.137). We also observed a significant association between *2/2 homozygote and cancer risk with comparison to allele*1 containing genotypes (OR = 1.714, 95%CI 1.408-2.088). Allele*2 is a risk factor for cancer risk (OR = 1.487, 95%CI 1.339-1.651). Stratified analysis by tumor type exhibits the significant association of this genetic variants with various cancers. In conclusion, LAPTM4B polymorphism is associated with cancer risk and allele*2 is a risk factor.
OnabotulinumtoxinA treatment for chronic migraine: experience in 52 patients treated with the PREEMPT paradigm
Authors: Pedraza María Isabel , de la Cruz Carolina , Ruiz Marina , López-Mesonero Luis , Martínez Elena , de Lera Mercedes , Guerrero Ángel Luis 
Published: April 2015

Abstract
OnabotulinumtoxinA (OnabotA) was approved for treatment of chronic migraine (CM) after publication of PREEMPT trials. Thus, we set out to evaluate the efficacy of OnabotA in a series of patients with CM treated according to the PREEMPT protocol.
In May 2012 we began to offer OnabotA to patients with CM who did not respond to topiramate and at least one other preventive therapy (beta blocker and/or calcium channel antagonist). We prospectively recorded demographic data and the characteristics of migraine, and we assessed the modifications in monthly headache and migraine days, as well as the number of days of symptomatic medication and triptan intake.
By September 2014 we had treated 52 patients (8 male, 44 female), whose age at treatment onset was 42.8 ± 12.7 years (range: 16–71) and age at migraine onset was 16.8 ± 7.8 years (3–32). In 43 of these patients (82.7%) symptomatic overuse of medication was observed at the onset of treatment. A total of 168 procedures were performed and after the first session, we observed a significant reduction in all the variables considered. Twelve (23.1%) patients failed to perceive a positive effect after the first procedure and it was not repeated in 4 of them. By contrast, there was a significant decreasing in all the variables evaluated compared to the baseline in the 39 patients that received a second series of injections.
The use of OnabotA according to the PREEMPT paradigm is an effective treatment in patients with chronic migraine in a real-life setting.
Phase I/II Study of HSP90 Inhibitor AUY922 and Erlotinib for EGFR-Mutant Lung Cancer With Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
Authors: Johnson Melissa L. , Yu Helena A. , Hart Eric M. , Weitner Bing Bing , Rademaker Alfred W. , Patel Jyoti D. , Kris Mark G. , Riely Gregory J. 
Published: April 2015

Purpose AUY922 is an HSP90 inhibitor that causes degradation of HSP chaperones and their client proteins, including epidermal growth factor receptor. We conducted a phase I/II trial to evaluate AUY922 and erlotinib for patients with EGFR-mutant lung cancer and disease progression during erlotinib treatment. Patients and Methods All patients had developed acquired resistance after treatment with erlotinib and underwent repeat tumor biopsies before study entry to assess for EGFR T790M. In phase I, 18 patients were treated with AUY922 intravenously once per week and erlotinib once per day in 28-day cycles using a 3 + 3 dose-escalation design. In phase II, 19 additional patients were treated at the maximum-tolerated dose. The primary end point of the phase II trial was complete plus partial response rate. Results In phase I (n = 18), three patients were treated in each cohort, except the highest-dose cohort (AUY922 70 mg and erlotinib 150 mg), which expanded to six patients because of a dose-limiting toxicity (ie, junctional cardiac rhythm). Common drug-related adverse events were diarrhea, skin rash, hyperglycemia, and night blindness. All patients treated at maximum-tolerated dose (n = 25) were evaluable for response. The partial response rate was 16% (four of 25 patients; 95% CI, 5% to 36%) and was independent of tumor T790M status. Conclusion Partial responses were observed, but the duration of treatment with AUY922 and erlotinib was limited by toxicities, especially night blindness. This phase II study of AUY922 and erlotinib did not meet its primary end point.
Efficient and Continuous Decomposition of Hydrogen Peroxide Using a Silica Capillary Coated with a Thin Palladium or Platinum Layer
Authors: Javaid Rahat , Qazi Umair Yaqub , Kawasaki Shin-Ichiro 
Published: April 2015

Abstract
The decomposition of hydrogen peroxide (H2O2) was studied using a silica capillary tube (o.d. 0.45 mm, i.d. 0.33 mm, length 1000 mm) coated with a thin palladium (Pd) or platinum (Pt) layer. The inner walls of the capillary were coated with a homogenous thin layer of metal by electroless plating. This metal-coated capillary provided rapid and continuous decomposition of H2O2 at room temperature within a residence time of 9.6 s, simply by passing the solution through the capillary. A capillary without Pd or Pt coating was unable to decompose H2O2 even at 50 °C. Pt proved to be a better catalyst than Pd. We also studied the effect of temperature, pH, concentration of H2O2 and the residence time on decomposition of H2O2.
Strategy of Structure Generation within Applicability Domains with One-Class Support Vector Machine
Authors: Kaneko Hiromasa , Funatsu Kimito 
Published: April 2015

Abstract
Generation of virtual chemical structures is applied in material, product, and drug designs to obtain structures having desired activity or properties. Quantitative structure–activity relationship (QSAR) models and quantitative structure–property relationship (QSPR) models are used to estimate values of activity and those of properties of structures, respectively. However, estimated values are unreliable when new structures are out of an applicability domain (AD) which is defined using a training data set. Data density around a new structure, which can handle nonlinearities between descriptors and multimodal data distributions, can be an index of ADs. We focus on one-class support vector machine (OCSVM) as a data density estimation method and propose a strategy of structure generation within ADs. The partial derivative of an OCSVM model with respect to each descriptor is used as a guideline to change each descriptor to get structures within ADs. It was confirmed that structures could be changed to increase data density around the structures, and could be generated within ADs through QSAR and QSPR data analyses.
Swamp Sistas: Beth McKee and a socio-musical swamp revival online and real time
Authors: Mills Susan Wilson 
Published: April 2015

Abstract
Beth McKee, the singer/songwriter known for her Mississippi roots and music-recording career created a community of mostly American women known as the Swamp Sistas. Although the network was developed to energize McKee’s female fan base, it quickly became a virtual and real-time social fabric, where artists, authors, colleagues and friends weave an ongoing tapestry of tradition and renewal. McKee’s performances, tours, merchandise and albums ground the artistic and social repertoire of the Swamp Sistas. The message of sharing with and supporting one another served as a powerful and creative vehicle for McKee’s musical presentations to new audiences. Her collaborations with educators, authors and artists fuelled the shared socio-musical trend, along with the performance venue she created in collaboration with the Swamp Sistas called the ‘La La’. The Swamp Sistas phenomenon is about fans who became co-creators. They inspired song lyrics, planned, staged and performed with McKee or in other groups at La Las, changing a musician and her audience into a community, complete with shared values and social engagement. This article describes the Swamp Sistas based on research in the field that included online and real time musical and social participant observation. Lessons from the swamp include emphasis on the participatory and co-creative culture of Swamp Sistas and implications for building community in music education settings.
‘Are you in a band?!’: Participatory music-making in music teacher education
Authors: Randles Clint , Griffis Sarah-Anne , Ruiz Jose Valentino 
Published: April 2015

Abstract
This article is the account of a music teacher educator, a doctoral student (teaching assistant) and a pre-service music teacher regarding the impact that an innovative course offering at a large research university in the south-eastern United States had on students’ perceptions of their musicianship and notions of what a music teacher is and does. Elements of Tom Turino’s participatory music-making, hi-fidelity and studio audio art (in addition to presentational music-making) were infused into a new course sequence. Students formed independently operated small groups and worked on original arrangements of popular music selections and original songs for both live performance and recording. Pre-service music teachers’ developing musicianship and notions of what a music teacher is and does were impacted. While the scope of the class and complimentary lab class incorporated all of the areas of music-making that Turino details in his work, this piece will focus on the incorporation of participatory music-making into music teacher education. The authors would also like to bring the work of Keith Sawyer into the conversation surrounding participatory music-making that includes elements of improvisation.
Strengthening choral community: The interaction of face-to-face and online activities amongst a college choir
Authors: O’Flynn John 
Published: April 2015

Abstract
This article reports on a small-scale study investigating the interaction of face-to-face and online group activities by members of a Dublin-based college choir (where the researcher is also a lecturer and choral leader) over a period of twelve months in 2009–2010. Research data are gathered by way of participation–observation of – and sometimes participation in – the choir’s Facebook page and through an extended real-time interview with a group of student choir members subsequently carried out in 2011. The overall analytic framework is sociological in orientation, utilizing distinctions between ‘sound’ and ‘musical–social’ groups, as well as ‘bonding’, ‘bridging’ and ‘maintained’ types of ‘social capital’. The review of literature examines notions of choral communities, online communities and the affordances of computer-mediated communication. Data analysis is presented in two sections: the first comprises a narrative interpretation of how face-to-face and online activities interacted over the period under review; the second raises a number of issues that emerge from the interview with students. Overall findings suggest a strong symbiotic relationship between the collective identity of the face-to-face choir and that of the online choral group. Affordances of social media and ‘clip culture’ are realized through series of mutually influential initiatives and interventions on the part of students and the choral leader, thereby bridging perceptions of the choir as institution and the choir as community.
Computing the exit-time for a finite-range symmetric jump process
Authors: Burch Nathanial , Lehoucq R. B. 
Published: April 2015

Abstract
This paper investigates the exit-time for a broad class of symmetric finite-range jump processes via the corresponding master equation, a nonlocal diffusion equation suitably constrained. In direct analogy to the classical diffusion equation with a homogeneous Dirichlet boundary condition, the nonlocal diffusion equation is augmented with a homogeneous volume-constraint. The volume-constrained master equation provides an efficient alternative over Monte Carlo simulation for computing an important statistic of the process. Several numerical examples are given.
Sin and Natural Theology: An Augustinian Framework Beyond Barth
Authors: Allen Paul L. 
Published: April 2015

AbstractThis article focuses on the question of sin in the context of natural theology‚ in light of the Barth/Brunner debate. A contemporary notion of sin would benefit from Barth’s approach, but shorn of his strict doctrine of sin as nothingness (‘Nichtiges’). Brunner holds to the Augustinian tradition’s claim that sin is a paradox by distinguishing between the formal and material in the
Removal of americium from effluent generated during the purification of plutonium by anion exchange
Authors: Noronha Donald M. , Pius Illipparambil C. , Chaudhury Satyajeet 
Published: April 2015

Abstract
Studies have been carried out on removal of americium from the effluent generated during anion exchange purification of
plutonium. Americium 241, generated by the beta decay of Plutonium-241, is the major source of α activity in this highly acidic
effluent and its removal would render the waste easily disposable. A simple and effective co-precipitation method, using thorium
oxalate has been investigated for the treatment of this alpha active aqueous waste. Experiments have been carried out to identify
optimum conditions to obtain high percentage co-precipitation with minimum amount of co-precipitant. Efforts were carried out to
correlate the optimum conditions of co-precipitation of americium obtained in these experiments with solubility of thorium oxalate and
americium oxalate calculated from solubility products of these compounds, stability constants of thorium and americium oxalate
complexes taken from literature. The saturation capacity of thorium oxalate for Am(III) was also calculated by analyzing the
K
d value data using Langmuir adsorption equation. The strong tendency of americium to get co-precipitated and the high
capacity exhibited by thorium oxalate for the uptake of americium indicate feasibility of using this method for the treatment of anion
exchange effluent.
Uranyl tris-(carbohydrazide) nitrate [UO2((N2H3)2CO)3](NO3)2: synthesis, structure and properties
Authors: Leshok Darya Y. , Alekseenko Vladimir N. , Gavrilov Peter M. , Alekseenko Sergei N. , Dyachenko Anton S. , Samoilo Alexander A. , Kondrasenko Alexander A. , Kirik Sergei D. 
Published: April 2015

Abstract
Uranyl tris-(carbohydrazide) nitrate [UO2((N2H3)2CO)3](NO3)2 was prepared by the
reaction of water solution of dioxouranium(VI) nitrate UO2(NO3)2(H2O)6 with ethanol solution of carbohydrazide
(N2H3)2CO in a molar ratio of 1 to 3 in an neutral medium. The substance was characterized by elemental, thermal
analysis and IR and 15N MAS CP NMR spectroscopy. Ab initio crystal structure determination was carried out using X-ray
powder diffraction techniques. The compound crystallizes in monoclinic lattice with unit cell parameters:
a = 15.193(1) Å, b = 12.005(1) Å, c = 10.842(1) Å, β = 109.15(1)○,
V = 1868.11 Å3, Z = 4, SG = Cc. The type of carbohydrazide coordination was additionally confirmed by
15N MAS CP NMR and IR spectroscopy. In the complex ion [UO2((N2H3)2CO)3]2+ three carbohydrazide ligands
coordinate to UO2
2+ through oxygen and nitrogen forming three five-membered chelate rings. The carbohydrazide rings are
tuned to the equatorial plane of complex. The crystal structure consists of zig-zag chains of [UO2((N2H3)2CO)3]2+
cations stretched along c-axis. The cations in the chain are linked by the hydrogen bonds between the cations themselves. The anions
are located in the pores between chains and participate in hydrogen bonding between adjacent chains and additionally link the chain
sections. The length of the chain section is 5.768 Å and the angle between sections is 140○. The
substance [UO2((N2H3)2CO)3](NO3)2 is thermally stable up to 215 ℃ and then decomposes with an
explosion.
Nuclear forensic analysis of uranium oxide powders interdicted in Victoria, Australia
Authors: Kristo Michael Joseph , Keegan Elizabeth , Colella Michael , Williams Ross , Lindvall Rachel , Eppich Gary , Roberts Sarah , Borg Lars , Gaffney Amy , Plaue Jonathan , Knight Kim , Loi Elaine , Hotchkis Michael , Moody Kenton , Singleton Michael , Robel Martin , Hutcheon Ian 
Published: April 2015

Abstract
Nuclear forensic analysis was conducted on two uranium samples confiscated during a police investigation in Victoria, Australia. The
first sample, designated NSR-F-270409-1, was a depleted uranium powder of moderate purity (∼ 1000 μg/g total
elemental impurities). The chemical form of the uranium was a compound similar to K2(UO2)3O4 · 4H2O. While
aliquoting NSR-F-270409-1 for analysis, the body and head of a Tineid moth was discovered in the sample. The second sample, designated
NSR-F-270409-2, was also a depleted uranium powder. It was of reasonably high purity (∼ 380 μg/g total elemental
impurities). The chemical form of the uranium was primarily UO3 · 2H2O, with minor phases of U3O8 and
UO2. While aliquoting NSR-F-270409-2 for analysis, a metal staple of unknown origin was discovered in the sample. The
presence of 236U and 232U in both samples indicates that the uranium feed stocks for these samples experienced
a neutron flux at some point in their history. The reactor burn-up calculated from the isotopic composition of the uranium is
consistent with that of spent fuel from natural uranium (NU) fueled Pu production. These nuclear forensic conclusions allow us to
categorically exclude Australia as the origin of the material and greatly reduce the number of candidate sources.
Autophagy in Alzheimer’s disease
Authors: Zare-shahabadi Ameneh , Masliah Eliezer , Johnson Gail V.W. , Rezaei Nima 
Published: April 2015

AbstractAutophagy is a vesicle and lysosome-mediated degradative pathway that is essential for protein homeostasis and cell health. In particular, compared to nonneuronal cells, neurons are dependent on high basal autophagy for survival. There is emerging agreement that defects in autophagy are likely to contribute to the neurodegenerative processes in numerous diseases, including Alzheimer’s disease (AD). Autophagy-lysosome defects occur early in the pathogenesis of AD and have been proposed to be a significant contributor to the disease process. Given the fact that autophagy deficits are likely major contributors to the etiology of AD, the focus of this review will be on recent studies that support a role for autophagy deficits in AD.
Surface modification of Ti alloys with WC-TiB2-reinforced laser composite coatings
Authors: Li Jianing , Zhang Yuanbin , Luo Hui , Gong Shuili , Li Peng , Huo Yushuang 
Published: April 2015

Abstract
Laser cladding of the TiAl/Fe+Co-coated WC+TiB2 pre-placed mixed powders on a Ti-6Al-4V alloy substrate can be used to form TiB2/α-W2C-reinforced composite coating, which improved the wear resistance of the substrate. To further improve the TiB2/α-W2C-reinforced composite coating, yttria partially stabilized zirconia (YPSZ) was added into the pre-placed powders. A metallurgical bonding was formed between the YPSZ-infused composite coating and the substrate. Many amorphous alloys were produced in this composite coating due to the action of YPSZ, and such coating showed fine microstructure. Thus, it is feasible to further improve the wear resistance of the laser clad TiB2/α-W2C-reinforced composite coating through the addition of YPSZ.
Microwave-assisted synthesis, structure and property of a spin-glass heptanuclear nickel cluster with 2-iminomethyl-6-methoxy-phenol
Authors: Zhang Shu-Hua , Li Gui , Zhang Hai-Yang , Li He-Peng 
Published: April 2015

Abstract
A new heptanuclear nickel cluster [Ni7(immp)6(OMe)6]·(ClO4)2 (1, Himmp is 2-iminomethyl-6-methoxy-phenol) has been synthesized through the microwave-assisted reaction of Ni(ClO4)2·6H2O with 2-hydroxy-3-methoxy-benzaldehyde and ammonium water in mixed solvent (acetonitrile: methanol = 1:1). Complex 1 was characterized by IR spectroscopy, elemental analysis and X-ray single-crystal diffraction. Magnetic property of 1 indicates the relaxation time τ
0 = 1.28 × 10–15 s and the energy barrier U
eff / k
B = 70.4 K, which is a spin glass.
A Class of Boundary Value Problems Arising in Mathematical Physics: A Green’s Function Fixed-point Iteration Method
Authors: Khuri Suheil , Sayfy Ali 
Published: April 2015

Abstract
This paper presents a method based on embedding Green’s function into a well-known fixed-point iteration scheme for the numerical solution of a class of boundary value problems arising in mathematical physics and geometry, in particular the Yamabe equation on a sphere. Convergence of the numerical method is exhibited and is proved via application of the contraction principle. A selected number of cases for the parameters that appear in the equation are discussed to demonstrate and confirm the applicability, efficiency, and high accuracy of the proposed strategy. The numerical outcomes show the superiority of our scheme when compared with existing numerical solutions.
Interaction between Barium Oxide and Barium Containing Chloride Melt
Authors: Nikolaeva Elena V. , Zakiryanova Irina D. , Korzun Iraida V. , Bovet Andrey L. , Antonov Boris D. 
Published: April 2015

Abstract
Thermal analysis was applied to determine the liquidus temperatures in the NaCl–KCl–BaCl2–BaO system, with BaO concentration varied from 0 to 6 mole%. The temperature dependence of the BaO solubility in the NaCl–KCl–BaCl2 eutectic melt was investigated; the thermodynamic parameters of BaO dissolution were calculated. The caloric effects of melting of the NaCl–KCl–BaCl2 eutectic with barium oxide and barium oxychloride additions were studied. The type, morphology, and composition of oxychloride ionic groupings in the melt were determined in situ using Raman spectroscopy.