bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of 18F‐FDG‐PET/CT in the management of Burkitt lymphoma
Authors: Carrillo‐Cruz Estrella , Marín‐Oyaga Víctor A. , Rodríguez María Solé , Borrego‐Dorado Isabel , de la Cruz Vicente Fátima , Quiroga Cantero Eduardo , Pérez Marina Manzanares , Capote Francisco J. , Ramírez Sánchez María J. , Espigado Tocino Ildefonso , Pérez‐Vega Herminia , Vázquez‐Albertino Ricardo , Pérez‐Simón Jose A. 
Published: February 2014

AbstractBurkitt lymphoma (BL) is highly FDG‐avid even though its usefulness in the management of these patients is still controversial.AimWe analyzed the role of positron emission tomography/computerized tomography (PET/CT) in staging newly diagnosed patients with BL and evaluating disease after first‐line chemotherapy.MethodsFifty‐two PET/CTs were performed in 32 patients (20 at diagnosis, 27 after treatment, five to monitor residual disease). Involved areas were retrospectively compared with those observed in contrast‐enhanced CT.ResultsDiscrepancies were found in 64.7% of patients for whom results of both tests at diagnosis were available (n = 17), most of them involving extranodal sites. Regarding response assessment, discrepancies were observed in 38% of patients with both tests (5/13): residual masses detected by CT with negative PET/CT. Of 27 patients with post‐treatment PET/CT, 22 were in complete remission whereas one true‐positive and four false‐positive lesions (two nodal and two extranodal) were detected. With a median follow‐up of 27 months, 22 patients with negative PET/CT did not relapse. Thus, negative predictive value (NPV) was 100%. With respect to positive predictive value (PPV), one of five patients with positive assays after treatment died due to progression while the remaining four had false‐positive lesions. Nevertheless, for these four patients, mean SUVmax at nodal sites was 4.1 vs. 14.9 at diagnosis, while mean SUVmax at extranodal sites was 3.8 vs. 12.1. Thus, with a cutoff value for SUVmax <66% of that observed at diagnosis, PPV was also 100%.ConclusionMore accurate staging can be achieved using PET/CT. NPV reaches 100%, and using a ΔSUV <66%, a high PPV is also observed.
Screening of major depression in epilepsy: The Neurologic Depression Disorders Inventory in Epilepsy‐Spanish version (Argentina)
Authors: Thomson Alfredo E. , Calle Analía , Fontela María E. , Yepez Luis , Muñoz Giacomelli Francisco , Jáuregui Agustín , Racosta Juan M. , Kanner Andrés M. 
Published: February 2014

SummaryObjectivesTo validate and translate the English version of the Neurologic Depression Disorders Inventory in Epilepsy (NDDI‐E) into Spanish as a screening instrument for major depressive episodes (MDE) for patients with epilepsy from Argentina and Uruguay.MethodsOne hundred fifty‐five consecutive outpatients with epilepsy participated in this study. The module of MDE of the MINI International Neuropsychiatric Instrument (MINI Plus version) was used as the gold standard against which the translated version of the NDDI‐E was validated.ResultsAmong the 155 patients, 25 (16%) met Diagnostic and Statistical Manual, Fourth Edition (DSM‐IV) criteria for MDE according to the MINI. With a total score of >15, The NDDI‐E identified MDE with an 80% sensitivity, 90% specificity, 60% positive predictive value, and 95.5% negative predictive value.SignificanceThese data indicate that the Spanish version of the NDDI‐E can reliably identify MDE in patients with epilepsy from Argentina and Uruguay.
Developmental brain abnormalities in tuberous sclerosis complex: A comparative tissue analysis of cortical tubers and perituberal cortex
Authors: Ruppe Véronique , Dilsiz Pelin , Reiss Carol Shoshkes , Carlson Chad , Devinsky Orrin , Zagzag David , Weiner Howard L. , Talos Delia M. 
Published: February 2014

SummaryObjectiveGenetic loss of Tsc1/Tsc2 function in tuberous sclerosis complex (TSC) results in altered mammalian target of rapamycin (mTOR) signaling and abnormal brain development. Although earlier studies have focused on characterization of cortical tubers, in this study we sought to examine the unique cellular and molecular features of the perituberal cortex in order to better understand its contribution to epileptogenesis, cognitive dysfunction, and autism.MethodsStandard histologic and immunohistochemical labeling was used to assess structural abnormalities and cell‐specific pattern of mTORC1 activation in surgically resected cortical tubers and perituberal cortex. Western blotting was performed to quantify the expression of the mTORC1 and mTORC2 biomarkers phospho‐S6 (Ser235/236), phospho‐S6 (Ser240/244), and phospho‐Akt (Ser473), in addition to evaluating the differential expression levels of several neuronal and glial‐specific proteins in tubers and peritubers, as compared to non‐TSC epilepsy specimens.ResultsTubers demonstrated mild to severe disruption of cortical lamination, the presence of pS6‐positive dysplastic neurons and giant cells, an overall increase in mTORC1 and a decrease in mTORC2 activity, increased axonal connectivity and growth, and hypomyelination. Perituberal cortex presented similar histologic, immunohistochemical, and molecular features; however, they were overall milder. Axonal growth was specific for TSC and was negatively correlated with deficient myelination.SignificanceOur results show an extension of cellular dysplasia and dysregulated mTOR signaling in the perituberal tissue, and demonstrate for the first time aberrant connectivity in human TSC brain. This study provides new insights into the pathophysiology of neurologic dysfunction associated with TSC and supports the intrinsic epileptogenicity of normal‐appearing perituberal cortex.A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.
Combined influence of expertise and fatigue on riding strategy and horse–rider coupling during the time course of endurance races
Authors: Viry S. , De Graaf J. B. , Frances J.‐P. , Berton E. , Laurent M. , Nicol C. 
Published: February 2014

SummaryReasons for performing studyThe relationship between the biomechanical horse–rider interaction and endurance race performance requires further investigation.ObjectivesTo characterise, both quantitatively and qualitatively, elite and advanced horse–rider dyads on the basis of the biomechanical horse–rider interaction during endurance races.Study designFive elite and 5 advanced horse–rider dyads were recorded duringCEI*/CEI** endurance races using 2 synchronised triaxial accelerometers each placed close to horse and rider centres of mass.MethodsFor each horse–rider dyad, analyses focused on the vertical displacements of horse and rider per stride. This allowed quantification of the proportional use of each gait and riding technique per loop. The quality of the biomechanical horse–rider interaction was examined through the relative phases (RP) of their respective vertical displacement minima. Instantaneous speed and rider heart rates were recorded using a global positioning system device/heart rate monitor.ResultsAll dyads predominantly used 2 riding techniques per gait. The 2‐point trot proportion was limited in both groups (11%). Throughout the race, the advanced horse–rider dyads showed a global stability in speed, in the proportion of 4 combinations of gait and riding techniques and in meanRP. However, the elite horse–rider dyads initially had higher meanRPvalues (P<0.01), and from mid‐race to the end an increasing proportion of sitting canter, with associated increases in racing speed (P<0.001) and in mean heart rate (P<0.01). IntradyadRPvariability in 2‐point canter increased in both groups (P<0.01).ConclusionsAccelerometers are a valuable tool to follow the quantitative and qualitative trends of the biomechanical horse–rider interaction during international endurance races. The overall results emphasise the influence of the level of expertise on the adopted gait and riding techniques, thus influencing the racing speed. It remains to be established whether fatigue and/or strategy underlie our observations.
Stochastic galactokinase expression underlies GAL gene induction in a GAL3 mutant of Saccharomyces cerevisiae
Authors: Kar Rajesh Kumar , Qureshi Mohd. Tanvir , DasAdhikari Akshay Kumar , Zahir Taiyeb , Venkatesh Kareenhalli V. , Bhat Paike Jayadeva 
Published: February 2014

GAL1 and GAL3 are paralogous signal transducers that functionally inactivate Gal80p to activate the Gal4p‐dependent transcriptional activation of GAL genes in Saccharomyces cerevisiae in response to galactose. Unlike a wild‐type strain, the gal3∆ strain shows delayed growth kinetics as a result of the signaling function of GAL1. The mechanism ensuring that GAL1 is eventually expressed to turn on the GAL switch in the gal3∆ strain remains a paradox. Using galactose and histidine growth complementation assays, we demonstrate that 0.3% of the gal3∆ cell population responds to galactose. This is corroborated by flow cytometry and microscopic analysis. The galactose responders and nonresponders isolated from the galactose‐adapted population attain the original bimodal state and this phenotype is found to be as hard wired as a genetic trait. Computational analysis suggests that the log‐normal distribution in GAL4 synthesis can lead to bimodal expression of GAL80, resulting in the bimodal expression of GAL genes. Heterozygosity at the GAL80 but not at the GAL1, GAL2 or GAL4 locus alters the extent of bimodality of the gal3∆ cell population. We suggest that the asymmetric expression pattern between GAL1 and GAL3 results in the ability of S. cerevisiae to activate the GAL pathway by conferring nongenetic heterogeneity.
A miniseries of spontaneous intramural esophageal hematoma in hemodialysis patients: A rare cause of dysphagia
Authors: Kumar Vinod , Hm Mallikarjuna , Gokulnath  
Published: February 2014

AbstractIntramural esophageal hematoma (IEH) is an uncommon clinical condition, with a prognosis that is essentially benign. In most cases, a predisposing factor may be seen, with the most common being the history of esophagic instrumentation, food impactions, and thrombocytopenia. We report a miniseries of 3 patients on hemodialysis, who developed IEH. All 3 of them presented with sudden onset and progressively worsening dysphagia and hematemesis. Diagnosis of IEH was established by upper gastrointestinal endoscopy. All patients were managed conservatively, and symptoms of dysphagia and chest pain improved within 6–8 days. Good resolution of hematoma was noted by repeat endoscopy within 2–3 weeks. The reported case of IEH in hemodialysis patients is rare and needs to be identified early when patients present with dysphagia, as anticoagulation during hemodialysis would possibly worsen the clinical condition, the course of which is otherwise benign.
Influence of Family Psychiatric and Headache History on Migraine‐Related Health Care Utilization
Authors: Minen Mia T. , Seng Elizabeth K. , Holroyd Kenneth A. 
Published: February 2014

ObjectiveWe sought to examine the relationship of family history of headache and family history of psychiatric disorders on self‐reported health care utilization tendencies for migraine treatment.BackgroundFamilial aggregation of both migraine and depression has been well established in the literature. Family history of headache and psychiatric disorders could influence health care utilization tendencies for migraine.MethodsThis is a secondary analysis of patients with severe migraine (n = 225) who answered questions about their family history, previous headache treatment history, disability (Headache Disability Inventory), and psychiatric symptoms (Beck Depression Inventory and Beck Anxiety Inventory). Using regression, we examined the relationship between family history of headache, depression, and anxiety and reported headache‐related health care utilization.ResultsParticipants reported family histories of headache (67.6%), anxiety (15.6%), and depression (29.3%). Participants reported seeing a physician for headache an average of 3.1 (standard deviation = 3.8) times in the past 2 years. In a 2‐year period, 27.6% of participants reported seeing a general practitioner and 18.5% of participants reported seeing a neurologist. Twenty‐eight percent of participants went to urgent care for headaches at least once in the last 2 years. Thirty‐nine percent of participants reported using non‐pharmacologic treatment for headache in the prior 2 years, with the highest rates of chiropractic manipulation (27.1%) and massage (18.2%), and fewest rates of biofeedback (0.4%), relaxation training (4.4%), psychotherapy (1.8%), physical therapy (4.9%), or acupuncture (1.8%). Family history of anxiety was associated with trying non‐pharmacologic treatments for headache, but no other self‐reported health care utilization variable. However, neither family history of headache nor family history of depression was associated with self‐reported health care utilization tendencies. Headache Disability Inventory was associated with self‐reported non‐pharmacologic treatments for headache.ConclusionsFamily history of anxiety, but not depression, was associated with utilizing non‐pharmacologic treatments for headache. Also, disability was associated with utilizing non‐pharmacologic treatments for headache. However, participants reported low rates of utilization for non‐pharmacologic treatments with grade‐A evidence.
Diagnostic PCR can be used to illuminate meiofaunal diets and trophic relationships
Authors: Maghsoud Hanna , Weiss Austin , Smith Julian P.S. , Litvaitis Marian K. , Fegley Stephen R. 
Published: February 2014

AbstractAnalysis of the meiofaunal food web is hampered because few prey have features that persist long enough in a predator's digestive tract to allow identification to species. Hence, at least for platyhelminth predators, direct observations of prey preference are almost nonexistent, and where they occur, prey identification is often limited to the phylum level. Studies using an in vitro approach are rare because they are extremely time‐consuming and are subject to the criticism that predators removed from their natural environment may exhibit altered behaviors. Although PCR‐based approaches have achieved wide application in food‐web analysis, their application to meiofaunal flatworms suffers from a number of limitations. Most importantly, the microscopic size of both the predator and prey does not allow for removal of prey material from the digestive tract of the predator, and thus the challenge is to amplify prey sequences in the presence of large quantities of predator sequence. Here, we report on the successful use of prey‐taxon‐specific primers in diagnostic PCR to identify, to species level, specific prey items of 13 species of meiofaunal flatworms. Extension of this method will allow, for the first time, the development of a species‐level understanding of trophic interactions among the meiofauna.
The analgesic effect of electrostimulation (WoundEL®) in the treatment of leg ulcers
Authors: Leloup Pauline , Toussaint Pascal , Lembelembe Jean‐Paul , Célérier Philippe , Maillard Hervé 
Published: February 2014

AbstractThis study aims to demonstrate the analgesic efficacy of electrostimulation (ES), a recognised treatment for leg ulcers. Patients treated by ES for leg ulcers between 2011 and 2013 were included in the study. The pain score obtained with the numerical rating scale (NRS) was reported before the start of the ES (D0), after 3 days (D3) and 1 week following treatment initialisation. The analgesic treatments (AT) were reported at each assessment. Seventy‐three patients were included (mean age 75·19 years): 31 venous leg ulcers, 21 mixed venous leg ulcers, 2 arterial ulcers, 17 hypertensive ischaemic ulcers, 1 Hydrea®‐induced ulcer and an amputation stump ulcer. The NRS at D0 was on average 5·3 (median = 6) while it was 2·2 at D7 (median = 2), that is P < 0·001. The results were also significant between D0 and D3 (P < 0·001). A decrease in the number of AT used was observed between D0 (2·0 AT per patient on average) and D7 (1·7 AT on average) (P < 0·001). We also observed a decrease in the consumption of grade 3 analgesics on D0 and D7 (P = 0·03). This study demonstrates the rapid analgesic efficacy of ES in leg ulcers, with a clear impact on the NRS score and especially on the decrease in analgesic consumption.
A large Italian observational multicentre study on vascular ulcers of the lower limbs (Studio Ulcere Vascolari)
Authors: Apollonio Alessandro , Antignani Pier L , Di Salvo Michelangelo , Failla Giacomo , Guarnera Giorgio , Mosti Giovanni , Ricci Elia ,   SUV Study Group
Published: February 2014

AbstractAn observational study of 2 years was promoted by the Italian Association for Cutaneous Ulcers (AIUC) in order to monitor the epidemiology of leg ulcers, the trend of healing and the more frequent therapeutic approaches in lower limb ulcers. Fifty‐nine sites in 14 different Italian regions involved in the study, with 1333 enrolled patients (1163 patients fully evaluated and followed up for 9 months). A prevalence of females (62%) was observed with a mean age of 70 years and a high rate of hypertension (62%), diabetes (38%) and obesity (29%). Venous ulcer was most frequent (55%), followed by mixed (25%) and diabetic (8·3%) ulcers. Basically, all patients received a local therapy (LT) (compression and advanced local therapies), while 63% of patients have an associated systemic pharmaceutical treatment. Ulcer healing rates progressively increased throughout the study and despite the type of observational study does not allow conclusions on the treatment, it was observed that the patients receiving additional systemic drugs were associated with a more rapid acceleration of healing rates of ulcers compared to LT alone (3 months: 39·7% versus 29·2%; 6 months: 62·0% versus 47·0%; 9 months: 74·7% versus 63·8%). In particular, the Studio Ulcere Vascolari (SUV) study showed that a combination treatment with sulodexide and compression therapy allows for a greater increase in the healing rates in venous ulcers.
Skin substitutes based on allogenic fibroblasts or keratinocytes for chronic wounds not responding to conventional therapy: a retrospective observational study
Authors: Pajardi Giorgio , Rapisarda Vicenzo , Somalvico Francesco , Scotti Andrea , Russo Giulia Lo , Ciancio Francesco , Sgrò Arturo , Nebuloni Manuela , Allevi Raffaele , Torre Maria L , Trabucchi Emilio , Marazzi Mario 
Published: February 2014

AbstractChronic wounds are an expression of underlying complex pathologies and have a high incidence. Skin substitutes may represent an alternative approach to treat chronic ulcers. The aim of this retrospective observational study was to evaluate the wound reduction using skin substitutes based on allogenic fibroblasts or keratinocytes in 30 patients not responding to conventional therapy. Wound bed was prepared, then keratinocytes on Laserskin® to treat superficial wounds or fibroblasts on Hyalograft 3DR to treat deep leg ulcers were applied, and finally wounds were treated with a secondary dressing composed of nanocrystalline silver. Once a week constructs were removed and new bioengineered products were applied, as well as nanocrystalline silver medication.In none of the cases under examination did any complications arise relating to the treatment. We also achieved a reduction in wound dimension and exudates, and an increase in wound bed score. Postoperative assessment shows a degree of healing that is statistically higher in the group treated with keratinocytes as compared with the fibroblast group.This retrospective study improves our understanding and defines the clinical indications for the various uses of the two types of skin substitutes.
Chronic oedema/lymphoedema: under‐recognised and under‐treated
Authors: Keast David H. , Despatis Marc , Allen Jill O. , Brassard Alain 
Published: February 2014

AbstractEven though it is estimated that at least 300 000 people in Canada may be affected by chronic oedema/lymphoedema, recognition of the seriousness of this chronic disease in health care is scarce. Lymphoedema affects up to 70% of breast and prostate cancer patients, substantially increasing their postoperative medical costs. Adding to this problem are the escalating rates of morbid obesity across North America and the fact that 80% of these individuals are thought to suffer with an element of lymphoedema. The costs related to these patient populations and their consumption of health care resources are alarming. Untreated chronic oedema/lymphoedema is progressive and leads to infection, disfigurement, disability and in some cases even death. Thus, prognosis for the patient is far worse and treatment is more costly when the disease is not identified and treated in the earlier stages. Although the number of individuals coping with chronic oedema/lymphoedema continues to increase, the disparity between diagnosis, treatment and funding across Canada endures. The reasons for this include a lack of public awareness of the condition, insufficient education and knowledge among health care providers regarding aetiology and management and limited financial coverage to support appropriate methods and materials.
The Canine Orthopedic Index. Step 2: Psychometric Testing
Authors: Brown Dorothy Cimino 
Published: February 2014

ObjectiveTo perform psychometric testing an owner self‐administered questionnaire, the Canine Orthopedic Index (COI), designed to assess outcome in dogs with orthopedic disease.Study DesignOriginal study.Sample PopulationOwners (n = 20) of dogs with osteoarthritis (OA) for item (question) pretesting, and 80 owners of dogs with OA for reliability and validity testing.MethodsStandard methodology for the stepwise development and testing of instruments designed to assess subjective states was followed. Items generated in previous studies were pretested for readability, ambiguity, and inter‐item correlations; poorly performing items were removed; and the reduced set of items subjected to factor analysis, reliability, and validity testing.ResultsFour factors were identified and named on the basis of the items contained in them: “Stiffness,” “Gait,” “Function,” and “Quality of Life.” Cronbach's α ranged from 0.76 to 0.86, suggesting the items in each factor could be assessed as a group to compute factor scores (i.e., stiffness, gait, function, and quality of life scores). The test–retest analysis revealed κ values from 0.68 to 0.80. Overall, the scores amongst the 4 factors correlated moderately well (r = 0.52–0.58), with a mild correlation (r = 0.35) between gait and function scores.ConclusionsThe COI is a psychometrically sound owner completed instrument that can assess 4 domains in dogs with OA: Stiffness, Gait, Function, and Quality of Life.
Negative Pressure Wound Therapy: Experience in 45 Dogs
Authors: Pitt Kathryn A. , Stanley Bryden J. 
Published: February 2014

ObjectiveTo report experience with negative pressure wound therapy (NPWT) in 45 consecutive dogs admitted with extensive cutaneous wounds and to determine if NPWT is feasible in veterinary hospital practice.Study DesignProspective descriptive study.AnimalsDogs (n = 45).MethodsCollected data were organized into 6 categories: patient data, wound data, NPWT data, adjunctive treatments, complications, and final outcome.ResultsWounds (53 in 45 dogs) were largely traumatic in origin, and distributed fairly evenly to the trunk, proximal and distal aspects of the limbs. Most wounds (34 dogs, 76%) had no granulation tissue and were treated a mean of 4.2 days after wounding, whereas 11 dogs had granulating wounds that were initially treated a mean of 87 days after wounding. Median NPWT use was 3 days with a mean hospitalization of 7.8 days. Most wounds (33; 62%) were closed surgically after NPWT and were healed by 14 days. The other 18 wounds healed (mean, 21 days) by second intention after hospital discharge. Overall, 96% of the wounds healed; 2 dogs died before definitive closure could be attempted.ConclusionNPWT is applicable to a wide variety of canine wounds, is well tolerated, allows for several days between dressing changes, and can used to optimize the wound bed for surgical closure or second intention healing.