bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacovigilance in pediatrics: adverse drug reactions in the use of antibacterial medicines for systemic use among children for the period of 2018-2022
Authors: Зайченко Г. В. , Бабенко М. М. , Ішкова Є. В. , Козак Д. О. , Башкатова Т. І. 
Published: August 2024

According to the WHO, antibacterial drugs for systemic use most often lead to adverse drug reactions, namely contribute to approximately 23% of all adverse events reported in the world. Children are more at risk of adverse drug reactions because a significant number of drugs prescribed in this population enter the market with limited experience in clinical trials of their efficiency and safety.
The aim of the work was to determine the main trends in the development of adverse reactions to antibacterial medicines for systemic use among children for the period 2018–2022.
The object of the study was notification cards on adverse reactions of medicines. In the course of the study, the following methods were applied: spontaneous messages and methods of statistical data processing.
A general analysis of the identified adverse reactions allows us to identify the following trends that were characteristic of each year of follow-up. In particular, it was found that the most common manifestations of adverse reactions to antibacterial drugs are skin rashes (39–51%), dyspeptic disorders (13–26%), hyperemia at the injection site (7–17%), urticaria-type rash (8–9%), headache and fever (3–4%). All these manifestations of adverse reactions belong to category B (dose-independent), due to the immunological characteristics of the child in response to the administration of the drug (active and excipients). Among the adverse reactions observed during this period, the following were distributed in terms of severity: fatal cases (2 reports in 2018); severe (anaphylactic shock from 4 cases in 2018 to 13 cases in 2019); moderate severity (urticaria, angioedema, an average of 4 to 13 cases per year).
According to the results of our scientific study, 3 053 report cards on cases of adverse reactions of antibacterial medicines for systemic use were analyzed. It has been found that in Ukraine, after the use of systemic antibacterial medicines, adverse reactions such as skin rashes and gastrointestinal adverse reactions (dyspeptic disorders) are three times less common in children, while in other countries (Brazil, USA), on the contrary, the latter are more common.
Ajuga reptans: Common Bugle, Bugleweed, Carpet Bugleweed
Authors: Gilman Edward , Klein Ryan W. , Hansen Gail 
Published: August 2024

This document provides an overview of Ajuga reptans, commonly known as bugleweed. It describes the plant’s characteristics, including its dark green to purple leaves, small blue flowers, and its growth habit as a ground cover. The document also details its planting requirements, such as preferred light conditions, soil tolerances, and USDA hardiness zones. Additionally, it highlights the plant’s uses in landscaping, potential invasive nature, and available cultivars. The document concludes with information on propagation, pest resistance, and aesthetic considerations for garden design. Original publication date October 1999.
Carica papaya: Papaya
Authors: Gilman Edward , Howe Teresa 
Published: August 2024

This document provides an overview of the Carica papaya, commonly known as papaya. It describes the plant’s characteristics, including its large, lobed leaves, single trunk, and edible fruit. The papaya is a fast-growing, short-lived shrub that thrives in full sun and well-drained soil. It is native to Mexico and Central America and can be used as a specimen, border, or accent plant in landscapes. The document also highlights the plant’s growth requirements, potential pest issues, and its ornamental value in addition to fruit production. Original publication date October 1, 1999.
Cosmos bipinnatus 'Sonata White' Sonata White Mexican Aster
Authors: Gilman Edward 
Published: August 2024

This document provides an overview of the sensation-type cosmos, specifically the Cosmos bipinnatus ‘Sonata White’. It details the plant’s characteristics, including its height, spread, and flower colors. The document also covers the plant’s growth requirements, such as full sun exposure and soil preferences, and discusses its moderate drought tolerance and pest resistance. Additionally, it highlights the plant’s uses in landscaping and its propagation methods, primarily through seeds. The document concludes with information on potential pests and diseases that may affect the plant. Original publication date October 1999.
Pelatihan Pemanfaatan Tools AI untuk Desain Produk dan Pembuatan Video bagi Siswa SMK N 1 Kotaagung Timur, Provinsi Lampung
Authors: Darwis Dedi , Putra Ade Dwi , Sulistiani Heni , Koeswara Wawan , Laksono Agung Pria 
Published: August 2024

Di era digital, kemampuan desain dan video menjadi semakin penting bagi siswa SMK. Namun, masih banyak siswa yang belum memiliki kemampuan ini. Pelatihan AI dapat membantu siswa membuat desain dan video yang lebih kreatif dan menarik. Perkembangan teknologi menuntut semua pihak untuk dapat mengapilkasikannya di segala bidang. Tak luput sekolah juga harus segera beradaptasi dengan kemajuan teknologi tersebut. Kegiatan Pengabdian Kepada Masyarakat (PKM) ini bertujuan untuk memberikan pengenalan dan pelatihan penggunaan tools AI untuk desain dan video kepada siswa SMK N 1 Kotaagung Timur jurusan Multimedia. Dengan adanya kegiatan PKM ini diharapkan siswa dapat meningkatkan kemampuan desain dan video, meningkatkan prospek karir, meningkatkan minat dan motivasi belajar, dan mempersiapkan siswa untuk masa depan. Kegiatan PKM ini memberikan pelatihan secara tatap muka kepada siswa jurusan multimedia dengan durasi 120 menit. Pelatihan AI sangat penting bagi siswa SMK untuk mempersiapkan mereka menghadapi masa depan yang penuh peluang.
Pelatihan Penyusunan Laporan Keuangan Pada UMKM Jamu Gendong “Mbak Eka” Berbasis Online Dengan Aplikasi Qasir
Authors: Sitanggang Friska Artaria , Windu Fitri Novi , Fabiany Nyayu Fadilah , Setiadi Henky , Simarmata Jonner 
Published: August 2024

Pelatihan penyusunan laporan keuangan bagi pelaku Usaha Mikro Kecil Menengah (UMKM) adalah salah satu kegiatan pengabdian masyarakat yang dilakukan pada pemilik usaha Jamu Gendong “Mbak Eka”. Tujuan kegiatan ini adalah untuk menambah wawasan serta kemampuan pelaku UMKM khususnya Jamu Mbak Eka dalam hal penyusunan laporan keuangan tidak hanya dapat dilakukan secara manual namun juga dapat melakukan penyusunan berbasis online yaitu dengan menggunakan aplikasi Qasir yang akan sangat berguna untuk pengembangan usaha yang dijalankan saat ini. Pelaksanaan kegiatan dilaksanakan pada Hari Jumat tanggal 05 Juli 2024 di tempat usaha jamu gendong yang beralamat di kelurahan RT 23 Kelurahan Tanjung Pinang, Kecamatan Jambi Timur, Kota Jambi. Metode pelaksanaan dilakukan dengan cara presentasi, diskusi dan juga praktek tentang cara yang efektif dalam menyusun laporan keuangan yang dapat diterapkan dalam usaha jamu ini. Pelaksanaan kegiatan pada pelatihan ini dapat terselenggara dengan sangat baik dimana peserta aktif dalam mengikuti kegiatan pelatihan.
Analisis Ketimpangan Regional Di Provinsi Lampung Tahun 2012-2022
Authors: Soraya Nadya 
Published: August 2024

Penelitian ini bertujuan menganalisis ketimpangan regional di Provinsi Lampung selama periode 2012-2022. Melalui pendekatan kuantitatf, dengan mengumpulkam data dan menganalisis data sekunder berbasis angka. Data diperoleh dari publikasi Badan Pusat statistik. Data yang digunakan yaitu data PDRB Provinsi Lampung dan 15 Kabupaten/Kota di Provinsi Lampung serta data jumlah penduduk di Provinsi Lampung pada tahun 2012-2022. Hasil penelitian ini menunjukkan bahwa Pertumbuhan ekonomi di Indonesia pada tahun 2012-2022 pertumbuhan ekonomi mengalami fluktuatif atau naik-turun. Hal ini terlihat dimana pertumbuhan ekonomi tertinggi diperoleh pada tahun 2012 dengan tingkat pertumbuhan ekonomi sebesar 6,44% sedangkan tingkat terendah berada pada tahun 2020 yang juga mengalami penurunan yang cukup signifikan sebesar -1.66. Pada tahun 2020 pertumbuhan ekonomi menurun tajam dari tahun sebelumnya akibat dampak COVID -19. Ketimpangan yang dihitung dengan Indeks Wiliamsom pada tahun 2012 dan 2013 terdapat ketimpangan yang sangat tinggi sedangkan dari tahun 2014-2022 ketimpangan yang terjadi masuk kedalam kategori ringan. Daerah yang memiliki kontribusi ketimpangan paling banyak adalah daerah yang maju dan tumbuh cepat (Lampung Tengah, Tulang Bawang, Bandar Lampung) dan daerah yang relatif tertinggal (Lampung Barat, Lampung Timur, Way Kanan, Pesawaran, Pesisir Barat).
Papaya Fruit Supply Chain System in Surabaya City: Towards a Better Food and Nutrition Urban Governance
Authors: Lamatungga Kiki Ekiawan , Abbas Hasriwiani Habo , Muhammad Nasir  , Arsyidik  
Published: August 2024

Papaya (Carica papaya Linn) is a tropical fruit with high economic and nutritional value. Indonesia was the fourth biggest papaya producer in the Asian continent from 2008 to 2018, and East Java was the primary contributor. Papaya has complex chemical components such as protein, carbohydrates, fat, fiber, minerals, and vitamins. However, its supply chain system faces challenges such as postharvest issues, processing and transportation, and low consumption. This study aimed to determine the papaya fruit supply chain system in Surabaya City to reform the existing food and nutrition action plan, which has not yet been fully implemented. With a toolkit from FAO called RUFSAT (Rapid Urban Food System Assessment Tool), the food system was developed with a primary concern on papaya commodities. Results indicated that the papaya supply chain in Surabaya is comprised of three channels: farmer to collector, wholesaler/distributor, retailer, and consumer. Acquisition and distribution of papaya still suffered from losses, food safety, transportation handling, packaging issues, and quality assurance practices. In terms of consumption, most households ingested papaya within 1-3 times per week, which is considered inadequate. Effective collaboration among city government agencies is pivotal for addressing supply chain complexities. In addition, integrating papaya with other fruits into urban farming initiatives can help to improve the nutritional status of Surabaya citizens.
New Perspectives of Flipbook as Asynchronous English Reading Media
Authors: Masykuri Edi Sunjayanto , Mezentse Ivan , Nebolsina M.S Nebolsina M.S , Anastasi Nathalie , Bin Kamin Yusri 
Published: August 2024

This purpose of the study was determining the students' attitudes toward the use of flipbook as English reading media. The teacher met the problem to accelerate the student’s skills because of the uninteresting, difficult lesson. They do find the less of time to study in school. The findings of this study provided a comprehensive response to the following question: how do students feel about the use of flipbook as English reading media; How flipbook can increase the students’ attention; and What are the challenges for student and teacher in education era 4.0. The mehod of the study was decriptive qualitative. The data was gathered by the researchers through the use of a questionnaire. In this study, there were twenty-seven students who were in their second semester junior high school. Case studies were the method of investigation for this project. In order to assess the data from the questionnaire, descriptive analysis was utilized. The findings of this study revealed that the students had a favorable opinion of flipbook as English reading materials. The average score on the questionnaire was 3.55, which places it in the "High" category when interpreted numerically. Some of these challenges were too large capacity, limited internet packages, and less supporting the old android.
Reliability analysis of mooring chains for floating offshore wind turbines
Authors: Li Guangming , Pan Tianguo , Feng Ruming , Zhu Liyun 
Published: August 2024

As offshore wind farms move into deeper waters, around 80 m, the high costs necessitate replacing bottom-fixed turbines with floating offshore wind turbines, which require mooring systems to maintain stability within design limits. Data from previous projects in China indicate that mooring systems can constitute about 20% of the total investment. Thus, reducing mooring system costs can significantly benefit the development of next-generation floating wind farms. This paper discusses the reliability analysis of mooring chains for floating wind turbines to optimize inspection plans and strategies, thereby saving on maintenance costs over their design lifetime. A case study on S-N curve based fatigue reliability analysis is conducted using both Monte Carlo Simulation and First Order Reliability Method (FORM), with consistent results from both methods. Additionally, three sensitivity analysis cases identify key parameters for the fatigue reliability analysis.
Physical exercise in amyotrophic lateral sclerosis: a potential co-adjuvant therapeutic option to counteract disease progression
Authors: Fenili Gianmarco , Scaricamazza Silvia , Ferri Alberto , Valle Cristiana , Paronetto Maria Paola 
Published: August 2024

Graphical AbstractEnergy metabolism is dysregulated in ALS patients. On the left panel, metabolic processes shown to be affected in ALS patients can be partially rescued with tailored low-impact exercise training protocols.
Chinese medicine PaBing-II protects human iPSC-derived dopaminergic neurons from oxidative stress
Authors: Wu Shouhai , Rong Cuiping , Lin Ruishan , Ji Kaiyuan , Lin Tongxiang , Chen Weimin , Mao Wei , Xu Yang 
Published: August 2024

BackgroundPaBing-II Formula (PB-II) is a traditional Chinese medicine for treating Parkinson’s disease (PD). However, owing to the complexity of PB-II and the difficulty in obtaining human dopaminergic neurons (DAn), the mechanism of action of PB-II in PD treatment remains unclear. The aim of this study was to investigate the mechanisms underlying the therapeutic benefits of PB-II in patients with PD.MethodshiPSCs derived DAn were treated with H2O2 to construct the DAn oxidative damage model. SwissTargetPrediction was employed to predict the potential targets of the main compounds in serum after PB-II treatment. Metascape was used to analyze the pathways. Sprague-Dawley rats were used to construct the 6-hydroxydopamine (6-OHDA)-induced PD model, and the duration of administration was four weeks. RNA sequencing was used for Transcriptome analysis to find the signal pathways related to neuronal damage. The associated inflammatory factors were detected by enzyme-linked immunosorbent assay (ELISA). We identified PB-II as an Nrf2 activator using antioxidant-responsive element luciferase assay in MDA-MB-231 cells.ResultsIn vitro experiments showed that the treatment of PB-II-treated serum increased the percentage of TH+ cells, decreased inflammation and the apoptosis, reduced cellular reactive oxygen species, and upregulated the expression of Nrf2 and its downstream genes. Pathway analysis of the RNA-seq data of samples before and after the treatment with PB-II-treated serum identified neuron-associated pathways. In vivo experiments demonstrated that PB-II treatment of PD rat model could activate the Nrf2 signaling pathway, protect the midbrain DAn, and improve the symptoms in PD rats.ConclusionPB-II significantly protects DAn from inflammation and oxidative stress via Nrf2 pathway activation. These findings elucidate the roles of PB-II in PD treatment and demonstrate the application of hiPSC-derived DAn in research of Chinese medicine.
Regional disparities in the prevalence and correlated factors of myopia in children and adolescents in Gansu, China
Authors: Wang Jinyu , Li Sheng , He Shiqi , Feng Yali , Li Pu 
Published: August 2024

BackgroundMyopia is a significant public health problem across the globe. This study aimed to examine the regional disparity in prevalence and correlated factors of myopia in children and adolescents in two typical regions, Gannan Tibetan Autonomous Prefecture (Gannan Prefecture for short, a Tibetan residential area) and Wuwei City (a Han residential area) in Gansu Province, China, and to provide a reference for the prevention and control of regional myopia.MethodsThe study was a cross-sectional study of children and adolescents in Gansu Province, China. A total of 6,187 (Wuwei City: 3,266, Gannan Tibetan Autonomous Prefecture: 2,921) students were selected by stratified cluster sampling. Eye examinations and questionnaires were administered to the participants. Myopia is defined as a condition in which the spherical equivalent refractive error of an eye is less than or equal to −0.50 D when ocular accommodation is relaxed. The χ2 test and multivariate logistic regression analysis were used to analyze the correlated factors of myopia.ResultsThe myopia rate of 6,187 students was 71.4%, and students had a higher rate of myopia (77.5%) in Wuwei City compared to Gannan Prefecture (64.6%) (p &lt; 0.001). The results of multivariate analysis in Wuwei City showed that girls (odds ratio (OR) = 1.325), junior students (OR = 2.542), senior students(OR = 4.605), distance between eyes and book less than one foot (OR = 1.291), and parents with myopia (one, OR = 2.437; two, OR = 4.453) had higher risks of myopia (all, p &lt; 0.05). For Gannan Prefecture, girls (OR = 1.477), senior students (OR = 1.537), daily time spent doing homework ≥2 h (OR = 1.420), the distance between eyes and book less than one foot (OR = 1.205), mean time continuous eye use (0.25–&lt;0.5 h, OR = 1.345, 0.5–&lt;1 h, OR = 1.317, ≥1 h, OR = 1.313), average daily sleep duration &lt;8 h (OR = 1.399), and parents with myopia (one, OR = 1.852; two, OR = 2.913) had higher risks of myopia (all, p &lt; 0.05).ConclusionThe prevalence of myopia is at a relatively high level in Gansu Province. The prevalence and risk factors for myopia vary by region.
Gut microbe-derived metabolites and the risk of cardiovascular disease in the METSIM cohort
Authors: Mirzaei Sahereh , DeVon Holli A. , Cantor Rita M. , Cupido Arjen , Fernandes Silva Lilian , Laakso Markku , Lusis Aldons J. 
Published: August 2024

BackgroundAn association between gut microbes and cardiovascular disease (CVD) has been established, but the underlying mechanisms remain largely unknown.MethodsWe conducted a secondary analysis of the cross-sectional data obtained from the Metabolic Syndrome in Men (METSIM) population-based cohort of 10,194 Finnish men (age = 57.65 ± 7.12 years). We tested the levels of circulating gut microbe-derived metabolites as predictors of CVD, ischemic cerebrovascular accident (CVA), and myocardial infarction (MI). The Kaplan–Meier method was used to estimate the time from the participants' first outpatient clinic visit to the occurrence of adverse outcomes. The associations between metabolite levels and the outcomes were assessed using Cox proportional hazard models.ResultsDuring a median follow-up period of 200 months, 979 participants experienced CVD, 397 experienced CVA, and 548 experienced MI. After adjusting for traditional risk factors and correcting for multiple comparisons, higher plasma levels of succinate [quartile 4 vs. quartile 1; adjusted hazard ratio, aHR = 1.30, (confidence interval (CI), 1.10–1.53) p = 0.0003, adjusted p = 0.01] were significantly associated with the risk of CVD. High plasma levels of ursodeoxycholic acid (UDCA) (quartile 3 vs. quartile 1); [aHR = 1.68, (CI, 1.26–2.2); p = 0.0003, adj. p = 0.01] were associated with a higher risk of CVA. Furthermore, as a continuous variable, succinate was associated with a 10% decrease in the risk of CVD [aHR = 0.9; (CI, 0.84–0.97); p = 0.008] and a 15% decrease in the risk of MI [aHR = 0.85, (CI, 0.77–0.93); p = 0.0007].ConclusionGut microbe-derived metabolites, succinate, and ursodeoxycholic acid were associated with CVD, MI, and CVA, respectively. Regulating the gut microbes may represent a potential therapeutic target for modulating CVD and CVA.
Omega-3 fatty acids abrogates oxido-inflammatory and mitochondrial dysfunction-associated apoptotic responses in testis of tamoxifen-treated rats
Authors: Odetayo Adeyemi Fatai , Akhigbe Roland Eghoghosoa , Hamed Moses Agbomhere , Balogun Morufu Eyitayo , Oluwole David Tolulope , Olayaki Luqman Aribidesi 
Published: August 2024

BackgroundTamoxifen (TAM) is a widely used drug in patients with gynecomastia and breast cancer. TAM exerts its anticancer effects via its antiestrogenic activities. Unfortunately, TAM has been reported to exert gonadotoxic effects on male testes. Therefore, this study was designed to explore the possible associated mechanisms involved in TAM-induced testicular dysfunction and the possible ameliorative effects of omega-3 fatty acids (O3FA).MethodologyAnimals were randomly divided into control, O3FA, TAM, and TAM + O3FA. All treatment lasted for 28 days.ResultsTAM exposure impaired sperm qualities (count, motility, and normal morphology) and decreased testicular 3β-HSD and 17β-HSD. It was accompanied by a decline in serum testosterone and an increase in estradiol, luteinizing and follicle-stimulating hormones. These observed alterations were associated with an increase in testicular injury markers, oxido-inflammatory response, and mitochondria-mediated apoptosis. These observed alterations were ameliorated by O3FA treatments.ConclusionsO3FA ameliorated TAM-induced testicular dysfunction in male Wistar rats by modulating XO/UA and Nrf2/NF-kb signaling and cytochrome c-mediated apoptosis in TAM-treated rats.
Testing calpain inhibition in tumor endothelial cells: novel targetable biomarkers against glioblastoma malignancy
Authors: Guarnaccia Laura , Navone Stefania Elena , Begani Laura , Barilla Emanuela , Garzia Emanuele , Campanella Rolando , Miozzo Monica , Fontana Laura , Alotta Giovanni , Cordiglieri Chiara , Gaudino Chiara , Schisano Luigi , Ampollini Antonella , Riboni Laura , Locatelli Marco , Marfia Giovanni 
Published: August 2024

IntroductionGlioblastoma IDH-wildtype (GBM) is the most malignant brain tumor in adults, with a poor prognosis of approximately 15 months after diagnosis. Most patients suffer from a recurrence in &lt;1 year, and this renders GBM a life-threatening challenge. Among molecular mechanisms driving GBM aggressiveness, angiogenesis mediated by GBM endothelial cells (GECs) deserves consideration as a therapeutic turning point. In this scenario, calpains, a family of ubiquitously expressed calcium-dependent cysteine proteases, emerged as promising targets to be investigated as a novel therapeutic strategy and prognostic tissue biomarkers.MethodsTo explore this hypothesis, GECs were isolated from n=10 GBM biopsies and characterized phenotypically by immunofluorescence. The expression levels of calpains were evaluated by qRT-PCR and Western blot, and their association with patients’ prognosis was estimated by Pearson correlation and Kaplan–Meier survival analysis. Calpain targeting efficacy was assessed by a time- and dose-dependent proliferation curve, MTT assay for viability, caspase-3/7 activity, migration and angiogenesis in vitro, and gene and protein expression level modification.ResultsImmunofluorescence confirmed the endothelial phenotype of our primary GECs. A significant overexpression was observed for calpain-1/2/3 (CAPN) and calpain-small-subunits-1/2 (CAPNS1), whereas calpastatin gene, the calpain natural inhibitor, was reported to be downregulated. A significant negative correlation was observed between CAPN1/CAPNS1 and patient overall survival. GEC challenging revealed that the inhibition of calpain-1 exerts the strongest proapoptotic efficacy, so GEC mortality reached the 80%, confirmed by the increased activity of caspase-3/7. Functional assays revealed a strong affection of in vitro migration and angiogenesis. Gene and protein expression proved a downregulation of MAPK, VEGF/VEGFRs, and Bcl-2, and an upregulation of caspases and Bax-family mediators.ConclusionOverall, the differential expression of calpains and their correlation with patient survival suggest a novel promising target pathway, whose blockade showed encouraging results toward precision medicine strategies.