bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconstructing the matter power spectrum with future cosmic shear surveys
Authors: Preston Calvin , Amon Alexandra , Efstathiou George 
Published: August 2024

ABSTRACT
Analyses of cosmic shear typically condense weak lensing information over a range of scales to a single cosmological parameter, $S_8$. This paper presents a method to extract more information from Stage IV cosmic shear measurements by directly reconstructing the matter power spectrum from linear to non-linear scales. We demonstrate that cosmic shear surveys will be sensitive to the shape of the matter power spectrum on non-linear scales. We show that it should be possible to distinguish between different models of baryonic feedback and we investigate the impact of intrinsic alignments and observational systematics on forecasted constraints. In addition to providing important information on galaxy formation, power spectrum reconstruction should provide a definitive answer to the question of whether weak lensing measurements of $S_8$ on linear scales are consistent with the Planck Lambda cold dark matter cosmology. In addition, power spectrum reconstruction may lead to new discoveries on the composition of the dark sector.
Ionospheric contributions to the excess power in high-redshift 21-cm power-spectrum observations with LOFAR
Authors: Brackenhoff S A , Mevius M , Koopmans L V E , Offringa A , Ceccotti E , Chege J K , Gehlot B K , Ghosh S , Höfer C , Mertens F G , Munshi S , Zaroubi S 
Published: August 2024

ABSTRACT
The turbulent ionosphere causes phase shifts to incoming radio waves on a broad range of temporal and spatial scales. When an interferometer is not sufficiently calibrated for the direction-dependent ionospheric effects, the time-varying phase shifts can cause the signal to decorrelate. The ionosphere’s influence over various spatiotemporal scales introduces a baseline-dependent effect on the interferometric array. We study the impact of baseline-dependent decorrelation on high-redshift observations with the Low Frequency Array (LOFAR). Data sets with a range of ionospheric corruptions are simulated using a thin-screen ionosphere model, and calibrated using the state-of-the-art LOFAR epoch of reionization pipeline. For the first time ever, we show the ionospheric impact on various stages of the calibration process including an analysis of the transfer of gain errors from longer to shorter baselines using realistic end-to-end simulations. We find that direction-dependent calibration for source subtraction leaves excess power of up to two orders of magnitude above the thermal noise at the largest spectral scales in the cylindrically averaged autopower spectrum under normal ionospheric conditions. However, we demonstrate that this excess power can be removed through Gaussian process regression, leaving no excess power above the 10 per cent level for a $5~$ km diffractive scale. We conclude that ionospheric errors, in the absence of interactions with other aggravating effects, do not constitute a dominant component in the excess power observed in LOFAR epoch of reionization observations of the North Celestial Pole. Future work should therefore focus on less spectrally smooth effects, such as beam modelling errors.
Dwarf males of the seven-arm octopus,Haliphron atlanticus:morphology and adaptations
Authors: Roura Alvaro , Bañón Rafael , de Carlos Alejandro , Valeiras Julio , Abad Esther , Serrano Alberto , Guerra Angel 
Published: August 2024

ABSTRACTThe Argonautoidea is a monophyletic superfamily of pelagic incirrate octopods primarily distinguished by an unusual means of copulation where a sexually modified arm, or hectocotylus, is detached and transferred from dwarf males to the female. Males of the seven-arm octopus Haliphron atlanticus are scarcely observed and little is known about their reproductive strategy. A detailed description of H. atlanticus digestive system, hectocotylus morphology, histology and functioning was carried out with fresh and preserved material from two males captured in the Bay of Biscay (North Atlantic). It is the first time that a hydrostatic sac/swimbladder in the anterior region of the intestine is described in an argonautoid male. Investing in reproductive rather than somatic growth is evident in the dwarf males of H. atlanticus, which lack the Needham sac and the terminal organ. Functionally, these organs have been replaced by two external modifications at the distal end of the detachable hectocotylus: a spermatophore reservoir with a single long spermatophore and a muscular penis, both essential to ensure fertilization once the hectocotylus is detached from the dwarf males. Haliphron has been considered a monospecific genus, with a single species distributed around the world. However, mitochondrial genetic analysis (cytochrome c oxidase subunit I and 16S ribosomal RNA) supports the existence of at least two species of Haliphron, one in the northern Atlantic and another in the southern Atlantic/Pacific. Further genetic and morphological studies are needed to unravel the diversity of this oceanic octopod family.
High-throughput determination of RNA tertiary contact thermodynamics by quantitative DMS chemical mapping
Authors: Lange Bret , Gil Ricardo G , Anderson Gavin S , Yesselman Joseph D 
Published: August 2024

Abstract
Structured RNAs often contain long-range tertiary contacts that are critical to their function. Despite the importance of tertiary contacts, methods to measure their thermodynamics are low throughput or require specialized instruments. Here, we introduce a new quantitative chemical mapping method (qMaPseq) to measure Mg2+-induced formation of tertiary contact thermodynamics in a high-throughput manner using standard biochemistry equipment. With qMaPseq, we measured the ΔG of 98 unique tetraloop/tetraloop receptor (TL/TLR) variants in a one-pot reaction. These results agree well with measurements from specialized instruments (R2= 0.64). Furthermore, the DMS reactivity of the TL directly correlates to the stability of the contact (R2= 0.68), the first direct evidence that a single DMS reactivity measurement reports on thermodynamics. Combined with structure prediction, DMS reactivity allowed the development of experimentally accurate 3D models of TLR mutants. These results demonstrate that qMaPseq is broadly accessible, high-throughput and directly links DMS reactivity to thermodynamics.
PHF8 facilitates transcription recovery following DNA double-strand break repair
Authors: Kim Jung Eun , Pan Xiyue , Tse Kwan Yiu , Chan Henry Hei , Dong Chao , Huen Michael Shing Yan 
Published: August 2024

Abstract
Transient halting of transcription activity on the damaged chromatin facilitates DNA double-strand break (DSB) repair. However, the molecular mechanisms that facilitate transcription recovery following DSB repair remain largely undefined. Notably, failure to restore gene expression in a timely manner can compromise transcriptome signatures and may impose deleterious impacts on cell identity and cell fate. Here, we report PHF8 as the major demethylase that reverses transcriptionally repressive epigenetic modification laid down by the DYRK1B–EHMT2 pathway. We found that PHF8 concentrates at laser-induced DNA damage tracks in a DYRK1B-dependent manner and promotes timely resolution of local H3K9me2 to facilitate the resumption of transcription. Moreover, PHF8 also assists in the recovery of ribosomal DNA (rDNA) transcription following the repair of nucleolar DSBs. Taken together, our findings uncover PHF8 as a key mediator that coordinates transcription activities during the recovery phase of DSB responses.
Interface-reinforced high-capacity fiber cathode for wearable Li–S batteries
Authors: Huang Lei , Zhou Tianzhu , Zhu Siyu , Yang Tianqi , Zhou Xuhui , He Bing , Wang Shuai , Yan Wei , Wei Lei 
Published: August 2024

ABSTRACT
Fiber-shaped Li–S batteries are attractive for constructing smart textiles as flexible power solutions due to their high theoretical specific capacity, flexibility and wearability. However, severe interfacial issues, such as the shuttle effect of polysulfides on the cathode side, lead to capacity decay and poor lifespan of the batteries. Herein, we report a fiber-shaped composite cathode with collaborative interface interactions to maintain electrode integrity and boost electrochemical performance. In this architecture, nanosulfur-polyvinylpyrrolidone (nanoS-PVP) particles are uniformly implanted into the few-layer Ti3C2Tx with outstanding electrical conductivity and then coated on aluminum (Al) fiber current collectors. Impressively, nanoS and soluble polysulfides are restricted to the cathode side via synergy physical confinement and chemical adsorption of Ti3C2Tx. The PVP chains on the surface of the nanoS prevent the sulfur from agglomeration and bridge the Ti3C2Tx by abundant hydrogen bonds. The enhanced interface endows the cathode with excellent mechanical flexibility, good adsorption of polysulfides and fast reaction kinetics. Consequently, the prepared Ti3C2Tx/nanoS-PVP@Al cathode exhibits excellent cycling performance (capacity retention of 92.8% after 1000 cycles at 1 C), high-rate capacity (556.2 mAh g−1 at 2.0 C) and high linear capacity (22.9 mAh m−1). Additionally, the fiber-shaped Li–S battery works effectively under deformation and high/low-temperature conditions. It can be integrated into the fabric to power light emitting diodes or charge a smartphone wirelessly.
Analytical approach to structural chemistry origins of mechanical, acoustical and thermal properties
Authors: Chen Zhiwei , Liu Wei , Shan Bing , Pei Yanzhong 
Published: August 2024

ABSTRACT
Crystalline matters with periodically arranged atoms found wide applications in modern science and technology. To facilitate the design of new materials and the advancement of existing ones, accurate and efficient models without relying too much on known inputs for predicting the functionalities are essential. Here, we propose an analytical approach for such a purpose, with only the knowledge of the structural chemistry of crystals. Based on the electrostatic interaction between periodically arranged atoms, the 1st, 2nd and 3rd derivatives of interatomic potential, respectively, enable a prediction of ten kinds in total of mechanical, acoustical and thermal properties. Over a thousand measurements are collected from ∼500 literatures, this results in the symmetric mean percentage error (SMPE) within ±25% and the symmetric mean absolute percentage error (SMAPE) ranging from 22%∼74% across all properties predicted, which further enables a revelation of bond characteristics as the most important but implicit origin for functionalities.
Postpartum onset Takayasu’s arteritis presenting with aortic dissection
Authors: Yamamoto Hirotaka , Taniguchi Yoshinori , Miura Yujiro , Kobayashi Shigeto 
Published: August 2024

Abstract
Takayasu’s arteritis (TA), also known as pulseless disease and young female arteritis, is a chronic inflammatory large-vessel vasculitis (LVV). TA is pathologically characterized by arterial wall thickening, stenotic/occlusive lesions, aneurysm formation, and dissection. TA usually develops between 20 and 30 years of age. However, pregnancy and puerperium can affect the immune system, and several cases of postpartum onset or flare-up of TA have been reported. Herein, we report an extremely rare case of postpartum-onset TA complicated by aortic dissection. This is a case of Postpartum onset Takayasu’s arteritis presenting with aortic dissection. A 34-year-old healthy woman was performed cesarean section. After 2 weeks, she presented with chest pain and fever, followed by mild dysphagia and hoarseness. Laboratory findings showed C-reactive protein (CRP) 21.61 mg/dl and computed tomography (CT) demonstrated thickening of the vessel wall of mainly ascending aorta. 18F-fluorodeoxyglucose (FDG)-position emission tomography (PET)/CT revealed high FDG uptake in the same areas. We diagnosed with TA and steroid pulse therapy was started. However, five days after treatment, the patient developed worsening symptoms of hoarseness. A contrast-enhanced CT showed Stanford A type dissection, and emergency artificial vessel replacement was performed. The specimen from surgical resection of the ascending aorta suggested active TA associated with dissection. The prednisolone dosage was gradually tapered with tocilizumab. Then, her symptoms and laboratory findings improved. It is important to recall the onset of TA and/or arterial dissection, when patients develop chest pain and hoarseness in the postpartum period.
Impact of HER2-targeted PET/CT imaging in patients with breast cancer and therapeutic response monitoring
Authors: Gui Xinyu , Liang Xu , Guo Xiaoyi , Yang Zhi , Song Guohong 
Published: August 2024

Abstract

Background
Patients with breast cancer exhibit heterogeneity in the expression of the human epithelial growth factor receptor 2 (HER2). Clinically, re-biopsying recurrent or metastatic lesions presents substantial challenges. This study aimed to evaluate the efficacy of HER2-targeted PET/CT imaging in identifying HER2 expression in breast cancer lesions and monitoring therapeutic responses.

Patients and Methods
This exploratory analysis used data from a prospective study that included adult patients with breast cancer who underwent both Al18F-NOTA-HER2-BCH and 18F-FDG PET/CT imaging at Beijing Cancer Hospital between June 2020 and July 2023 (NCT04547309).

Results
Fifty-nine participants, with a median age of 55 years, were analyzed. Lesions imaged with HER2-targeted PET/CT before anti-HER2 therapy exhibited higher SUVmax values than after therapy in HER2 immunohistochemistry (IHC) 3 + lesions (19.9, 95% CI: 15.7-25.3 vs 9.8, 95% CI: 5.6-14.7; P = .006). A significant positive correlation was observed between SUVmax on HER2-targeted PET/CT and IHC before therapy (P = .034), with higher SUVmax values noted in lesions with positive HER2 pathology compared to those with negative HER2 status (17.9 ± 13.2 vs 1.1 ± 0.3; P = .007). HER2 expression heterogeneity was confirmed both between primary and metastatic lesions (22.9%) and among different metastatic sites (26.7%) as assessed by HER2-targeted PET/CT. A superior therapeutic response correlated with higher pretreatment SUVmax values. The HER2-targeted PET/CT procedure was well-tolerated by all patients.

Conclusion
HER2-targeted PET/CT imaging offers a practical, non-invasive, and quantitative approach for assessing HER2 status in breast cancer patients, facilitating the optimization and personalization of therapeutic strategies by oncologists.
Thinking about China’s Response to the COVID-19 Outbreak
Authors: Yang Dali L. 
Published: August 2024

Abstract
This introductory chapter begins by establishing a personal connection with the reader through a recollection of initial reactions to the news of the Wuhan coronavirus outbreak in December 2019. It then delves into the broader themes of how organizational culture, leadership, epidemic information, and cognitive biases can impact disaster response efforts. The rest of the chapter previews the book. Key topics include the political-institutional context for health emergency response in China’s party-state, how the politics of stability and information control hampered the flows of epidemic information, the critical role of cognitive framework and the alarms that led to the decision to impose cordon sanitaire in Wuhan, and the politics of providing aid to Wuhan and enforcing the lockdown.
When AIs become oracles: generative artificial intelligence, anticipatory urban governance, and the future of cities
Authors: Cugurullo Federico , Xu Ying 
Published: August 2024

Abstract
Generative Artificial Intelligence (AI) is boosting anticipatory forms of governance, through which state actors seek to predict the future and strategically intervene in the present. In this context, city brains represent an emerging type of generative AI currently employed in urban governance and public policy in a growing number of cities. City brains are large-scale AIs residing in vast digital urban platforms, which manage multiple urban domains including transport, safety, health, and environmental monitoring. They use Large Language Models (LLMs) to generate visions of urban futures: visions that are in turn used by policymakers to generate new urban policies. In this paper, we advance a twofold contribution. Theoretically, we develop a critical theory of anticipatory governance in the age of generative AI. More specifically, we focus on technocratic approaches to anticipatory governance, to explain how the act of governing extends into the future by means of predictive AI technology. Our approach is critical in order to expose the dangers that the use of AI (generative AI, in particular) in urban governance poses, and to identify their causes. These dangers include the formation of a policy process that, under the influence of unintelligible LLMs, risks losing transparency and thus accountability, and the marginalization of human stakeholders (citizens, in particular) as the role of AI in the management of cities keeps growing and governance begins to turn posthuman. Empirically, we critically examine an existing city brain project under development in China and ground our critical theory in a real-life example.
How many meanings does ‘woman’ have?
Authors: Richard Mark 
Published: August 2024

Abstract
Talia Mae Bettcher argues that gender terms like ‘woman’ have multiple meanings, as different speakers use these terms to pick out different classes—some use ‘woman’ to pick out (roughly) the class of those assigned female at birth; some use it to pick out a class including both that class and trans women. Bettcher is correct, I argue: it is undeniable that ‘woman’ has quite different referents in different speakers' mouths; there is furthermore a kind of conventional meaning which varies across speakers associated with gender terms, one which tracks and varies with these different referential practices.
Management and outcomes of interstitial lung disease associated with anti-synthetase syndrome: a systematic literature review
Authors: Kouranloo Koushan , Dey Mrinalini , Elwell Helen , Yioe Veronica , Spencer Lisa G , Cotton Caroline V 
Published: August 2024

Abstract

Objectives
Anti-synthetase syndrome (ASS) is a chronic autoimmune condition, with interstitial lung disease (ILD) being a key feature. This systematic literature review (SLR; CRD42023416414) aimed to summarize treatments and outcomes of ILD associated with ASS (ASS-ILD).

Methods
Databases were searched for articles discussing ASS-ILD management and outcomes, published 1946–September 2023. Screening and data extraction were performed by two reviewers. Meta-analysis, using a random effects model, and paired t-tests were undertaken where appropriate to evaluate post-treatment-change in pulmonary function tests.

Results
Ten articles were included, comprising 514 patients: 67.8% female, mean age 52.4 years (s.d. 4.6). Baseline high-resolution CT was documented in 447 patients (86.9%); the most common pattern was non-specific interstitial pneumonia (n = 220; 49.2%). The most common myositis-associated autoantibody was anti-Jo1 (48%), with 27.8% having associated anti-Ro52 antibodies. Pooled estimate, after meta-analysis, for baseline forced vital capacity (FVC) was 60.8% predicted (s.e. 2.1) and for diffusion capacity of lungs for carbon monoxide (DLco) was 49.8% (s.e. 3.5). After 1 year, pooled improvement in FVC was 14.1% from baseline (s.e. 3.1) and in DLco was 15.1% (s.e. 2.8). Paired t-test demonstrated significant overall improvement in FVC (P = 0.007) and DLco (P = 0.002). Patients receiving rituximab had 12.2% improvement in FVC and 2.9% increase in DLco at 1 year; for patients receiving CYC, there was 17% improvement and 6.3% increase, respectively. Twenty-eight deaths were reported.

Conclusion
Our SLR, the first to summarize management and outcomes of ASS-ILD, found no conclusive difference between effectiveness of treatments. More robust trials are required to reduce morbidity and mortality resulting from ASS-ILD.
Measuring Cognitive Impairments Associated With Schizophrenia in Clinical Practice: Overview of Current Challenges and Future Opportunities
Authors: Nuechterlein Keith H , Nasrallah Henry , Velligan Dawn 
Published: August 2024

Abstract

Background
Cognitive impairment associated with schizophrenia (CIAS) negatively impacts daily functioning, quality of life, and recovery, yet effective pharmacotherapies and practical assessments for clinical practice are lacking. Despite the pivotal progress made with establishment of the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) for clinical research, implementation of the full MCCB is too time-consuming and cost-ineffective for most clinicians in clinical practice.

Study Design
Here we discuss current assessments in relation to delivery format (interview-based and performance-based), validity, ease of use for clinicians and patients, reliability/reproducibility, cost-effectiveness, and suitability for clinical implementation. Key challenges and future opportunities for improving cognitive assessments are also presented.

Study results
Current assessments that require 30 min to complete would have value in clinical settings, but the associated staff training and time required might preclude their application in most clinical settings. Initial profiling of cognitive deficits may require about 30 min to assist in the selection of evidence-based treatments; follow-up monitoring with brief assessments (10–15 min in duration) to detect treatment-related effects on global cognition may complement this approach. Guidance on validated brief cognitive tests for the strategic monitoring of treatment effects on CIAS is necessary.

Conclusions
With increased advancements in technology-based and remote assessments, development of validated formats of remote and in-person assessment, and the necessary training models and infrastructure required for implementation, are likely to be of increasing clinical relevance for future clinical practice.
The moral accounting of debts: productivity, deservingness and the consensual creation of Chapter XIII bankruptcy
Authors: Pang Nicholas A 
Published: August 2024

Abstract
Chapter XIII’s wage-earner payment plans are now the default form of personal bankruptcy in the USA. During the Great Depression, it was created as a voluntary choice and enacted with unanimous legislative support. Absent conflict between creditors and labor and social reformers, legislators agreed that Chapter XIII was for the benefit of both honorable insolvents and their fair creditors. How did wage-earner payment plans emerge out of a consensual legislative process? Employing a computational abductive approach on a wide range of legislative, media and bankruptcy records, I show that Chapter XIII’s creation was facilitated by a ‘moral accounting’ that, based on their race and gender identities, positively evaluated most White men bankruptcy petitioners as ‘deserving’, even as it recognized occupational variations in their economic ‘productivity’. This study highlights how racial discourses of ‘deservingness’ are central to the construction of credit markets as part of America’s submerged welfare state.