bluuebunny/crossref_metadata_2025_split huggingface dataset:
New mechanisms that regulate Saccharomyces cerevisiae short peptide transporter achieve balanced intracellular amino acid concentrations
Authors: Melnykov Artem V. 
Published: October 2015

AbstractThe budding yeast Saccharomyces cerevisiae is able to take up large quantities of amino acids in the form of di‐ and tripeptides via a short peptide transporter, Ptr2p. It is known that PTR2 can be induced by certain peptides and amino acids, and the mechanisms governing this upregulation are understood at the molecular level. We describe two new opposing mechanisms of regulation that emphasize potential toxicity of amino acids: the first is upregulation of PTR2 in a population of cells, caused by amino acid secretion that accompanies peptide uptake; the second is loss of Ptr2p activity, due to transporter internalization following peptide uptake. Our findings emphasize the importance of proper amino acid balance in the cell and extend understanding of peptide import regulation in yeast. Copyright © 2015 John Wiley & Sons, Ltd.
Relationships Among Disease, Social Support, and Perceived Health: A Lifespan Approach
Authors: Heinze Justin E. , Kruger Daniel J. , Reischl Thomas M. , Cupal Suzanne , Zimmerman Marc A. 
Published: October 2015

AbstractWe examined the relationship between the cumulative presence of major disease (cancer, stroke, diabetes, heart disease, and hypertension), social support, and self‐reported general and emotional well‐being in a community representative sample of predominantly White and African American respondents (N= 1349). Across all ages, greater presence of disease predicted poorer reported general health, and predicted lower emotional well‐being for respondents 40 and above. In contrast, social support predicted better‐reported general and emotional well‐being. We predicted that different types of social support (blood relatives, children, friends, community members) would be relatively more important for health in different age groups based on a lifespan or life stage model. This hypothesis was supported; across all ages, social support was related to better reported general and emotional health, but sources of support differed by age. Broadly, those in younger age groups tended to list familial members as their strongest sources of support, whereas older group members listed their friends and community members. As a whole, social support mediated the effect of disease on reported well‐being, however, moderated mediation by type of support was not significant. The results are consistent with a lifespan approach to changing social ties throughout the life course.
Human Rights, Legal Pluralism, and the Freedom of Religion in Malaysia
Authors: BLANCH Samuel D. 
Published: October 2015

AbstractThe so-called crisis of human rights requires a precise diagnosis. Through a theoretical discussion of human rights and legal pluralism in the context of the freedom of religion in Malaysia, this paper suggests that the crisis ought to be understood as something vital to the character of rights. Crisis is not tangential to the human rights project: rights are political objects engendering political responses. Beginning with an excursion into legal positivism and liberalism, the paper argues that analyses of rights based on abstraction and presumptions of homogeneity are confounded in contexts of contested plurality. Secondly, legal pluralism is raised as a more suitable framework for rights. Finally, Augustine and Schmitt offer some clues as to how the political status of human rights might be properly acknowledged. The prominent Malaysian case ofLina Joyprovides an ongoing commentary on the dangers of divorcing human rights from this essential political character.
The association between childhood maltreatment, psychopathology, and adult sexual victimization in men and women: results from three independent samples
Authors: Werner K. B. , McCutcheon V. V. , Challa M. , Agrawal A. , Lynskey M. T. , Conroy E. , Statham D. J. , Madden P. A. F. , Henders A. K. , Todorov A. A. , Heath A. C. , Degenhardt L. , Martin N. G. , Bucholz K. K. , Nelson E. C. 
Published: October 2015

BackgroundChildhood maltreatment (CM) has consistently been linked with adverse outcomes including substance use disorders and adult sexual revictimization. Adult sexual victimization itself has been linked with psychopathology but has predominately been studied in women. The current investigation examines the impact of CM and co-occurring psychopathology on adult sexual victimization in men and women, replicating findings in three distinct samples.MethodWe investigated the association between continuous CM factor scores and adult sexual victimization in the Childhood Trauma Study (CTS) sample (N = 2564). We also examined the unique relationship between childhood sexual abuse (CSA) and adult sexual victimization while adjusting for co-occurring substance dependence and psychopathology. We replicated these analyses in two additional samples: the Comorbidity and Trauma Study (CATS; N = 1981) and the Australian Twin-Family Study of Alcohol Use Disorders (OZ-ALC; N = 1537).ResultsAnalyses revealed a significant association with CM factor scores and adult sexual victimization for both men and women across all three samples. The CSA factor score was strongly associated with adult sexual victimization after adjusting for substance dependence and psychopathology; higher odds ratios were observed in men (than women) consistently across the three samples.ConclusionsA continuous measure of CSA is independently associated with adult sexual trauma risk across samples in models that included commonly associated substance dependence and psychopathology as covariates. The strength of the association between this CSA measure and adult sexual victimization is higher in magnitude for men than women, pointing to the need for further investigation of sexual victimization in male community samples.
Ignaz Philipp Semmelweis, The Prophet of Bacteriology
Authors: Wykticky Helmut , Skopec Manfred 
Published: October 2015

AbstractAlthough by 1931 I. Ph. Semmelweis' achievements and the tragedy of his life had been given their due place in the history of mankind, Alexander Fränkel, formerly Theodor Billroth's assistant and later his biographer, critically stated that the discoverer of the causes of puerperal fever should have defended his discovery with facts rather than with fanaticism. It was only a few years after Semmelweis' death, for instance, that Billroth made laborious experiments. Billroth's work on Coccobacteria had important implications and even influenced Robert Koch, although his hypotheses did not really predict the pathogenic and specific nature of microbes. In 1847 Semmelweis postulated his theory; ie, that the pathological-anatomical changes which he observed in the bodies of the women who died in childbed, in their newborn infants, and in the autopsy findings on his friend Jakob Kolletschka were an entity, morphologically and clinically. He summed them up under the concept of pyemia. Even though Semmelweis was continually abhorred by the evident statistics and would have been able to prove his discovery through animal experiments, he primarily took to the pen to defend his opinion vehemently. Only the clinical facts proved him right during his lifetime; the triumph of bacteriology which began after his death made him not only the “savior of mothers” but also a genial ancestor of bacteriology.
The Neurobiology of Substance and Behavioral Addictions
Authors: Grant Jon E. , Brewer Judson A. , Potenza Marc N. 
Published: October 2015

ABSTRACTBehavioral addictions, such as pathological gambling, kleptomania, pyromania, compulsive buying, and compulsive sexual behavior, represent significant public health concerns and are associated with high rates of psychiatric comorbidity and mortality. Although research into the biology of these behaviors is still in the early stages, recent advances in the understanding of motivation, reward, and addiction have provided insight into the possible pathophysiology of these disorders. Biochemical, functional neuroimaging, genetic studies, and treatment research have suggested a strong neurobiological link between behavioral addictions and substance use disorders. Given the substantial co-occurrence of these groups of disorders, improved understanding of their relationship has important implications not only for further understanding the neurobiology of both categories of disorders but also for improving prevention and treatment strategies.
The Use of Mood Stabilizers and Atypical Antipsychotics in Children and Adolescents With Bipolar Disorders
Authors: Kowatch Robert A. , DelBello Melissa P. 
Published: October 2015

ABSTRACTThe clinical use of mood stabilizers and antipsychotics in children and adolescents with bipolar disorders has increased significantly over the past few years. These agents have multiple effects and interactions. This articles reviews the studies that support the use of mood stabilizers and atypical antipsychotics in children and adolescents with bipolar disorders and presents information on these agent's pharmacokinetics, dosing, and drug interactions.
SNRIs: The Pharmacology, Clinical Efficacy, and Tolerability in Comparison with Other Classes of Antidepressants
Authors: Stahl Stephen M. , Grady Meghan M. , Moret Chantal , Briley Mike 
Published: October 2015

AbstractThe class of serotonin and norepinephrine reuptake inhibitors (SNRIs) now comprises three medications: venlafaxine, milnacipran, and duloxetine. These drugs block the reuptake of both serotonin (5-HT) and norepinephrine with differing selectivity. Whereas milnacipran blocks 5-HT and norepinephrine reuptake with equal affinity, duloxetine has a 10-fold selectivity for 5-HT and venlafaxine a 30-fold selectivity for 5-HT. All three SNRIs are efficacious in treating a variety of anxiety disorders. There is no evidence for major differences between SNRIs and SSRIs in their efficacy in treating anxiety disorders. In contrast to SSRIs, which are generally ineffective in treating chronic pain, all three SNRIs seem to be helpful in relieving chronic pain associated with and independent of depression. Tolerability of an SNRI at therapeutic doses varies within the class. Although no direct comparative data are available, venlafaxine seems to be the least well-tolerated, combining serotonergic adverse effects (nausea, sexual dysfunction, withdrawal problems) with a dose-dependent cardiovascular phenomenon, principally hypertension. Duloxetine and milnacipran appear better tolerated and essentially devoid of cardiovascular toxicity.
The Effect of Pathological Gambling on Families, Marriages, and Children
Authors: Shaw Martha C. , Forbush Kelsie T. , Schlinder Jessica , Rosenman Eugene , Black Donald W. 
Published: October 2015

ABSTRACTPathological gambling (PG) is widely reported to have negative consequences on marriages, families, and children. Empirical evidence is only now accumulating but when put together with anecdotal information, the extent of these problems is clear. PG contributes to chaos and dysfunction within the family unit, disrupts marriages, leading to high rates of separation and divorce, and is associated with child abuse and neglect. Divorce rates are high, not surprising in light of reports that these marriages are often abusive. Research shows that the families of pathological gamblers are filled with members who gamble excessively, suffer from depressive or anxiety disorders, and misuse alcohol, drugs, or both. Families of persons with PG are also large, a variable independently related to family dysfunction. The authors review the evidence on the impact of PG on families, marriages, and offspring, and make recommendations for future research targeting these problems.
Pension reform in an OLG model with heterogeneous abilities
Authors: BUYSE TIM , HEYLEN FREDDY , VAN DE KERCKHOVE RENAAT 
Published: October 2015

AbstractWe study the effects of pension reform on hours worked, human capital, income and welfare in an open economy populated by four overlapping generations: three active generations (the young, the middle aged and the older) and one generation of retired. Within each generation we distinguish individuals with high, medium or low ability to build human capital. Our simulation results prefer a pay-as-you-go pension system with a particular earnings-related linkage above a fully-funded private system. This pay-as-you-go system conditions pension benefits on past individual labor income, with a high weight on labor income earned when older and a low weight on labor income earned when young. Uncorrected, however, such a system implies welfare losses for current low-ability generations and rising inequality. Complementing or replacing it by basic and/or minimum pension components is negative for aggregate employment and welfare. Better is to maintain the tight link between individual labor income and the pension also for low-ability individuals, but to strongly raise their replacement rate. An additional correction improving the welfare of low-ability individuals would be to maintain for these individuals equal weights on past labor income.
Use of a values inventory as a discussion aid about end-of-life care: A pilot randomized controlled trial
Authors: Menon Shailaja , McCullough Laurence B. , Beyth Rebecca J. , Ford Marvella E. , Espadas Donna , Braun Ursula K. 
Published: October 2015

AbstractObjective:We examined the utility of a brief values inventory as a discussion aid to elicit patients' values and goals for end-of-life (EoL) care during audiotaped outpatient physician–patient encounters.Method:Participants were seriously ill male outpatients (n = 120) at a large urban Veterans Affairs medical center. We conducted a pilot randomized controlled trial, randomizing 60 patients to either the intervention (with the values inventory) or usual care. We used descriptive statistics and qualitative methods to analyze the data. We coded any EoL discussions and recorded the length of such discussions.Results:A total of 8 patients (13%) in the control group and 13 (23%) in the intervention group had EoL discussions with a physician (p = 0.77). All EoL discussions in the control group were initiated by the physician, compared with only five (38%) in the intervention group. Because most EoL discussions took place toward the end of the encounter, discussions were usually brief.Significance of results:The outpatient setting has been promoted as a better place for discussing EoL care than a hospital during an acute hospitalization for a chronic serious illness. However, the low effectiveness of our intervention calls into question the feasibility of discussing EoL care during a single outpatient visit. Allowing extra time or an extra visit for EoL discussions might increase the efficacy of advance care planning.
Revolution Imagined: Cause Advocacy, Consumer Rights, and the Evolving Role of NGOs in Thailand
Authors: Munger Frank 
Published: October 2015

AbstractThis article describes the founding and evolution of a “Thai-style” NGO dedicated to consumer protection. Through a description of the NGO and the career of its founder, the article brings to light features of the evolution of NGO-based advocacy in Thailand from the student uprising in 1973 to the present. The legacy of the 1973 October Generation of activists continues to influence development of NGOs but new emphasis on rights has emerged since the era of constitutional reform in the 1990s. Many NGOs now make use of litigation to attempt to achieve social change, but litigation, like other long-standing methods of advocacy involving reliance on networks that penetrate government itself, reflect the particular opportunities and pathways for change opened by Thailand’s politics.
Internal Structure and Partial Invariance across Gender in the Spanish Version of the Reasoning Test Battery
Authors: Elosua Paula , Mujika Josu 
Published: October 2015

AbstractThe Reasoning Test Battery (BPR) is an instrument built on theories of the hierarchical organization of cognitive abilities and therefore consists of different tasks related with abstract, numerical, verbal, practical, spatial and mechanical reasoning. It was originally created in Belgium and later adapted to Portuguese. There are three forms of the battery consisting of different items and scales which cover an age range from 9 to 22. This paper focuses on the adaptation of the BPR to Spanish, and analyzes different aspects of its internal structure: (a) exploratory item factor analysis was applied to assess the presence of a dominant factor for each partial scale; (b) the general underlined model was evaluated through confirmatory factor analysis, and (c) factorial invariance across gender was studied. The sample consisted of 2624 Spanish students. The results concluded the presence of a general factor beyond the scales, with equivalent values for men and women, and gender differences in the factorial structure which affect the numerical reasoning, abstract reasoning and mechanical reasoning scales.
Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1
Authors: Lin Zhenghong , Tan Can , Qiu Quan , Kong Sinyi , Yang Heeyoung , Zhao Fang , Liu Zhaojian , Li Jinping , Kong Qingfei , Gao Beixue , Barrett Terry , Yang Guang-Yu , Zhang Jianing , Fang Deyu 
Published: October 2015

AbstractThe elevated level of CCNB1 indicates more aggressive cancer and poor prognosis. However, the factors that cause CCNB1 upregulation remain enigmatic. Herein, we identify USP22 as a CCNB1 interactor and discover that both USP22 and CCNB1 are dramatically elevated with a strong positive correlation in colon cancer tissues. USP22 stabilizes CCNB1 by antagonizing proteasome-mediated degradation in a cell cycle-specific manner. Phosphorylation of USP22 by CDK1 enhances its activity in deubiquitinating CCNB1. The ubiquitin ligase anaphase-promoting complex (APC/C) targets USP22 for degradation by using the substrate adapter CDC20 during cell exit from M phase, presumably allowing CCNB1 degradation. Finally, we discover that USP22 knockdown leads to slower cell growth and reduced tumor size. Our study demonstrates that USP22 is a CCNB1 deubiquitinase, suggesting that targeting USP22 might be an effective approach to treat cancers with elevated CCNB1 expression.
Uniaxial stress control of skyrmion phase
Authors: Nii Y. , Nakajima T. , Kikkawa A. , Yamasaki Y. , Ohishi K. , Suzuki J. , Taguchi Y. , Arima T. , Tokura Y. , Iwasa Y. 
Published: October 2015

AbstractMagnetic skyrmions, swirling nanometric spin textures, have been attracting increasing attention by virtue of their potential applications for future memory technology and their emergent electromagnetism. Despite a variety of theoretical proposals oriented towards skyrmion-based electronics (that is, skyrmionics), few experiments have succeeded in creating, deleting and transferring skyrmions, and the manipulation methodologies have thus far remained limited to electric, magnetic and thermal stimuli. Here, we demonstrate a new approach for skyrmion phase control based on a mechanical stress. By continuously scanning uniaxial stress at low temperatures, we can create and annihilate a skyrmion crystal in a prototypical chiral magnet MnSi. The critical stress is merely several tens of MPa, which is easily accessible using the tip of a conventional cantilever. The present results offer a new guideline even for single skyrmion control that requires neither electric nor magnetic biases and consumes extremely little energy.
The deuterium/hydrogen distribution in chondritic organic matter attests to early ionizing irradiation
Authors: Laurent Boris , Roskosz Mathieu , Remusat Laurent , Robert François , Leroux Hugues , Vezin Hervé , Depecker Christophe , Nuns Nicolas , Lefebvre Jean-Marc 
Published: October 2015

AbstractPrimitive carbonaceous chondrites contain a large array of organic compounds dominated by insoluble organic matter (IOM). A striking feature of this IOM is the systematic enrichment in deuterium compared with the solar hydrogen reservoir. This enrichment has been taken as a sign of low-temperature ion-molecule or gas-grain reactions. However, the extent to which Solar System processes, especially ionizing radiation, can affect D/H ratios is largely unknown. Here, we report the effects of electron irradiation on the hydrogen isotopic composition of organic precursors containing different functional groups. From an initial terrestrial composition, overall D-enrichments and differential intramolecular fractionations comparable with those measured in the Orgueil meteorite were induced. Therefore, ionizing radiation can quantitatively explain the deuteration of organics in some carbonaceous chondrites. For these meteorites, the precursors of the IOM may have had the same isotopic composition as the main water reservoirs of the inner Solar System.
Coevolution Pattern and Functional Conservation or Divergence of miR167s and their targets across Diverse Plant Species
Authors: Barik Suvakanta , Kumar Ashutosh , Sarkar Das Shabari , Yadav Sandeep , Gautam Vibhav , Singh Archita , Singh Sharmila , Sarkar Ananda K. 
Published: October 2015

AbstractmicroRNAs (miRNAs), a class of endogenously produced small non-coding RNAs of 20–21 nt length, processed from precursor miRNAs, regulate many developmental processes by negatively regulating the target genes in both animals and plants. The coevolutionary pattern of a miRNA family and their targets underscores its functional conservation or diversification. The miR167 regulates various aspects of plant development in Arabidopsis by targeting ARF6 and ARF8. The evolutionary conservation or divergence of miR167s and their target genes are poorly understood till now. Here we show the evolutionary relationship among 153 MIR167 genes obtained from 33 diverse plant species. We found that out of the 153 of miR167 sequences retrieved from the “miRBase”, 27 have been annotated to be processed from the 3′ end and have diverged distinctively from the other miR167s produced from 5′ end. Our analysis reveals that gma-miR167h/i and mdm-miR167a are processed from 3′ end and have evolved separately, diverged most resulting in novel targets other than their known ones and thus led to functional diversification, especially in apple and soybean. We also show that mostly conserved miR167 sequences and their target AUXIN RESPONSE FACTORS (ARFs) have gone through parallel evolution leading to functional diversification among diverse plant species.
Structural basis for recognition of Emi2 by Polo-like kinase 1 and development of peptidomimetics blocking oocyte maturation and fertilization
Authors: Jia Jia-Lin , Han Young-Hyun , Kim Hak-Cheol , Ahn Mija , Kwon Jeong-Woo , Luo Yibo , Gunasekaran Pethaiah , Lee Soo-Jae , Lee Kyung S. , Kyu Bang Jeong , Kim Nam-Hyung , Namgoong Suk 
Published: October 2015

AbstractIn a mammalian oocyte, completion of meiosis is suspended until fertilization by a sperm and the cell cycle is arrested by a biochemical activity called cytostatic factor (CSF). Emi2 is one of the CSFs and it maintains the protein level of maturation promoting factor (MPF) by inhibiting ubiquitin ligase anaphase promoting complex/cyclosome (APC/C). Degradation of Emi2 via ubiquitin-mediated proteolysis after fertilization requires phosphorylation by Polo-like kinase 1 (Plk1). Therefore, recognition and phosphorylation of Emi2 by Plk1 are crucial steps for cell cycle resumption, but the binding mode of Emi2 and Plk1 is poorly understood. Using biochemical assays and X-ray crystallography, we found that two phosphorylated threonines (Thr152 and Thr176) in Emi2 are each responsible for the recruitment of one Plk1 molecule by binding to its C-terminal polo box domain (PBD). We also found that meiotic maturation and meiosis resumption via parthenogenetic activation were impaired when Emi2 interaction with Plk1-PBD was blocked by a peptidomimetic called 103-8. Because of the inherent promiscuity of kinase inhibitors, our results suggest that targeting PBD of Plk1 may be an effective strategy for the development of novel and specific contraceptive agents that block oocyte maturation and/or fertilization.