bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structural disorganization of pronephric glomerulus in Zebrafish mpp5a/nagie oko mutant
Authors: Ichimura Koichiro , Fukuyo Yayoi , Nakamura Tomomi , Powell Rebecca , Sakai Tatsuo , Obara Tomoko 
Published: October 2012

AbstractBackground: The podocyte slit diaphragm (SD) is an essential component of the selective filtration barrier in the glomerulus. Several structural proteins required for formation and maintenance of SD have been identified; however, molecular mechanisms regulating these proteins are still limited. Results: Here, we demonstrate that MAGUK p55 subfamily member 5a (Mpp5a)/Nagie oko, a component of the Crb multi‐protein complex, was colocalized with an SD‐associated protein ZO‐1 in the zebrafish pronephric glomerulus. To characterize the function of Mpp5a, zebrafish mpp5am520 mutant embryos, which are known to have defects in cardiac and neuronal morphogenesis, were analyzed. These mutants failed to merge the bilateral glomerular primordia and to form the glomerular capillary and mesangium, but the foot processes and SD showed normal appearance. The structural disorganization in the mpp5am520 mutant glomerulus was quite similar to that of a cardiac troponin T2a/tnnt2a/silent heart knockdown zebrafish, which exhibited circulatory failure due to lack of heart beating. Conclusions: Mpp5a is not prerequisite to form podocyte slit diaphragm in the pronephric glomerular development in zebrafish. The structural disorganization of the pronephric glomerulus in the mpp5am520 mutant is likely to result from circulatory failure, rather than the anomaly of Mpp5a protein in the glomerulus. Developmental Dynamics, 2012. © 2012 Wiley Periodicals, Inc.
Interactions between Drosophila IgCAM adhesion receptors and cindr, the Cd2ap/Cin85 ortholog
Authors: Johnson Ruth I. , Bao Sujin , Cagan Ross L. 
Published: October 2012

AbstractBackground: Morphogenetic modeling of tissues requires coordinated regulation of adhesion. For its correct patterning, the Drosophila pupal eye requires several Immunoglobulin superfamily cell adhesion molecules (IgCAMs) and the adaptor protein Cindr. Orthologs of these proteins are essential components of specialized junctions of the vertebrate kidney; the Cindr ortholog Cd2ap is essential for the integrity of this structure. Results: Reducing Cindr during fly eye development led to incorrect distribution of the IgCAMs Roughest (Rst) and Hibris (Hbs). Both bound Cindr. Disrupting endocytosis similarly led to Rst and Hbs mis‐localization; our data suggests an additional early requirement for endocytosis in regulating Hbs localization or stability. Finally, Rst and Hbs localized correctly only when in stable membrane complexes and we propose that Cindr anchors these to the cytoskeleton. This regulation likely does not extend to IgCAMs Kin of irre (Kirre) and Sticks and stones (Sns) in the pupal eye; neither interacted with Cindr in in vitro assays. Nonetheless, Kirre and Sns partially mis‐localized when Cindr was reduced, possibly due to interactions with Rst/Hbs. Conclusions: Our data suggests Cindr recapitulates both proposed functions of its mammalian orthologs Cd2ap and Cin85: targeting the IgCAMs Rst and Hbs for endocytosis and stabilizing these heterophilic IgCAM complexes. Developmental Dynamics, 2012. © 2012 Wiley Periodicals, Inc.
Genetic diversity and geographic distribution of Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) genotypes associated with cassava in East Africa
Authors: Mugerwa Habibu , Rey Marie E. C. , Alicai Titus , Ateka Elijah , Atuncha Hellen , Ndunguru Joseph , Sseruwagi Peter 
Published: October 2012

AbstractThe genetic variability of whitefly (Bemisia tabaci) species, the vectors of cassava mosaic begomoviruses (CMBs) in cassava growing areas of Kenya, Tanzania, and Uganda, was investigated through comparison of partial sequences of the mitochondria cytochrome oxidase I (mtCOI) DNA in 2010/11. Two distinct species were obtained including sub‐Saharan Africa 1 (SSA1), comprising of two sub‐clades (I and II), and a South West Indian Ocean Islands (SWIO) species. Among the SSA1, sub‐clade I sequences shared a similarity of 97.8–99.7% with the published Uganda 1 genotypes, and diverged by 0.3–2.2%. A pairwise comparison of SSA1 sub‐clade II sequences revealed a similarity of 97.2–99.5% with reference southern Africa genotypes, and diverged by 0.5–2.8%. The SSA1 sub‐clade I whiteflies were widely distributed in East Africa (EA). In comparison, the SSA1 sub‐clade II whiteflies were detected for the first time in the EA region, and occurred predominantly in the coast regions of Kenya, southern and coast Tanzania. They occurred in low abundance in the Lake Victoria Basin of Tanzania and were widespread in all four regions in Uganda. The SWIO species had a sequence similarity of 97.2–97.7% with the published Reunion sequence and diverged by 2.3–2.8%. The SWIO whiteflies occurred in coast Kenya only. The sub‐Saharan Africa 2 whitefly species (Ug2) that was associated with the severe CMD pandemic in Uganda was not detected in our study.
Co‐development of alluvial fan surfaces and arid botanical communities, Stonewall Flat, Nevada, USA
Authors: Dickerson Robert Paul , Forman Amy , Liu Tanzhuo 
Published: October 2012

ABSTRACTArid alluvial fan and fluvial dry wash surfaces in Stonewall Flat, Nevada, USA, are characterized using surface geomorphic surveys, soil pits, botanical line surveys, and varnish microlamination dating techniques. Active and abandoned washes, and active fan surfaces are dominated by primary geomorphic processes of high‐energy sedimentation from flash floods. These surfaces are characterized by bar and swale topography, a lack of stone pavements, soil horizons, and rock varnish. Younger terraces and slightly older intermediate fan surfaces are in transition from primary sedimentation processes to lower energy secondary surface‐modifying processes of sheet wash and eolian transport and deposition. These surfaces are characterized by faint to no bar and swale topography, incipient to moderately well‐developed pavements and soil horizons, and abundant coppices. Old and stable fan surfaces are dominated by lower energy secondary processes and manifest well‐developed pavements, soils, and sparse coppices around widely distributed shrubs. Varnish microlamination dating yields ages of 13·15 ka for intermediate fan surfaces and 25·55 to 86·75 ka for stable fan surfaces. Plant communities co‐developing with these surfaces affect and are affected by both primary and secondary geomorphic fan processes. Relatively active surfaces contain few woody species. Co‐dominance of shrubs and annuals with abundant annuals between the shrubs is characteristic of surfaces transitional from primary processes to secondary processes. Stable surfaces dominated by secondary processes are characterized by woody perennials, with long‐lived woody species inhabiting the oldest surfaces. Feedback mechanisms between early botanical communities and eolian deposition affect coppice and pavement development. In turn, these surface features control both the composition and distribution of botanical communities on older, more stable surfaces. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
A ‘well‐balanced’ finite volume scheme for blood flow simulation
Authors: Delestre O. , Lagrée P.‐Y. 
Published: October 2012

SUMMARYWe are interested in simulating blood flow in arteries with a one‐dimensional model. Thanks to recent developments in the analysis of hyperbolic system of conservation laws (in the Saint‐Venant shallow water equations context) we will perform a simple finite volume scheme. We focus on conservation properties of this scheme, which were not previously considered. To emphasize the necessity of this scheme, we present how a too simple numerical scheme may induce spurious flows when the basic static shape of the radius changes. On the contrary, the proposed scheme is ‘well‐balanced’: it preserves equilibria of Q = 0. Then examples of analytical or linearized solutions with and without viscous damping are presented to validate the calculations. The influence of abrupt change of basic radius is emphasized in the case of an aneurism. Copyright © 2012 John Wiley & Sons, Ltd.
30.2: UD Resolution 240Hz LCD TV Display System with High Speed Driving
Authors: You Bong Hyun , Bae Jae Sung , Park Dong Won , Hong Seok Ha , Saito Satoru , Moon Ju Tae 
Published: October 2012

AbstractThe Ultra high Definition (3840times2160) resolution, 70″ LCD TV with 240Hz frame rate has been developed. A cost effective single bank driving architecture with multi‐chip structure is realized by adopting a vertical quarter partitioned (VQP) and overlap data exchange (ODX) driving scheme. Even though half‐gate two‐data line design (hG‐2D) is adopted to overcome the charging time limitation, scan line overlapping driving scheme has also been implemented to enhance the actual pixel charging performance. The 240Hz frame rate driving technology makes 3‐dimensional display through temporal division such as 3D display of active shutter glass possible. Furthermore, a novel up‐scaling algorithm with inventive single‐frame super‐resolution methodologies has been invented to cope with input display data of FHD resolution.
54.4: Binocular Color‐rivalry Thresholds of Complex Images
Authors: Sun Pei‐Li , Chang Ting‐Yuan , Luo Ronnier M. 
Published: October 2012

AbstractBinocular color‐rivalry thresholds of 7 types of tone variations are estimated. The results show that the thresholds for luminance differences are much larger than that of contrast and hue. To have a better 3D quality assessment, not only color differences but also between‐eye tone differences must be taken into account.
58.2: Distinguished Paper: Implementation of 240Hz 55‐inch Ultra Definition LCD Driven by a‐IGZO Semiconductor TFT with Copper Signal Lines
Authors: Gong Namyong , Park Chonghun , Lee Junho , Jeong Ilgi , Han Hwadong , Hwang Jeongtae , Park Joonmin , Park Kwonshik , Jeong Hoon , Ha Yongmin , Hwang Yongkee 
Published: October 2012

AbstractWe have implemented a 240Hz 55‐inch ultra definition (UD, or 3840times2160) resolution TV panel using amorphous IGZO TFT. As the resolution and the frame rate of a panel increase, pixel charging time and panel transmittance ratio decrease. Among various data driving architectures, the data single 1G1D driving renders cost benefit, process competitiveness and design flexibility. To apply this driving architecture to a high resolution, high mobility of TFT and low RC delay are required. We suggest a‐IGZO TFT and copper metallization technology as a solution.
65.1: Effective Spatial Resolution of Temporally and Spatially Interlaced Stereo 3D Televisions
Authors: Kim Joohwan S. , Banks Martin S. 
Published: October 2012

AbstractWe measured the effective spatial resolution of temporally and spatially interlacing of stereo three‐dimensional (S3D) televisions at three different viewing distances: 1.5, 3 and 6 times picture height. Temporally interlacing S3D television has significantly better effective resolution at viewing distances of 1.5 and 3 times picture height.
74.1L: Late‐News Paper: Oxide TFTs and Color Filter Array Technology for Flexible Top‐emission White OLED Display
Authors: Noda Makoto , Teramoto Kazuma , Fukumoto Eri , Fukuda Toshihiro , Shimokawa Keisuke , Saito Takatoshi , Tanikawa Toru , Suzuki Masato , Izumi Gaku , Kumon Satoshi , Arai Toshiaki , Kamei Takahiro , Kodate Manabu , No Sonhi , Sasaoka Tatsuya , Nomoto Kazumasa 
Published: October 2012

AbstractWe have developed a direct fabrication method of oxide TFT on a flexible substrate and a flexible color filter array (CFA) technology for white OLED. The oxide TFT is successfully integrated on the flexible substrate and the fabricated display achieved wide color gamut of NTSC (in CIE u'v' space) more than 100%.
P‐55: High Performance Sealant in One Drop Filling Process of Mobile Thin Filter Transistor Liquid Crystal Display Product
Authors: Xiao Ang , Zhu Haibo , Song S.H. , Chen Xu , Min T.Y. , Ryu B.Y. , Lee S.K. 
Published: October 2012

AbstractIn this paper, we developed a new one drop filling (ODF) sealant for mobile thin film transistor liquid crystal display (TFT‐LCD) products. In the new sealant, traditional inorganic filler was decreased, organic filler was increased and nano‐silica‐balls were newly applied. Experimental results indicated the new sealant had the advantage in dispensing ability, adhesive strength, anti‐shock ability and pollution to inner liquid crystal (LC).
P‐146L: Late‐News Poster: Development of a Photochromic Circular Polarizer for OLEDs
Authors: Koma Norio , Hashizume Masaharu , Yamamoto Michiyuki , Sato Yoko 
Published: October 2012

AbstractA photochromic circular polarizer was studied for use in organic light‐emitting‐diode displays (OLEDs). This polarizer transmits light emitted from an OLED efficiently under ambient light, extending the life and lowering the power consumption of the OLED. Under bright ambient light, the polarizer changes to a high degree of polarization and low transmittance, which maintains the contrast ratio and retains image visibility by reducing light reflection from the OLED electrodes. An outdoor experiment confirmed that the photochromic circular polarizer enhanced the contrast ratio of the OLED.
Osteology and postmetamorphic development of Telmatobius oxycephalus (Anura: Telmatobiidae) with an analysis of skeletal variation in the genus
Authors: Barrionuevo J. Sebastián 
Published: October 2012

AbstractThe osteological diversity among species of Telmatobius has been considered conservative. Nonetheless, the degree of ossification of several features varies both intraspecifically and interspecifically. Herein, intraspecific osteological variation and postmetamorphic ontogenetic changes in osteological features are described in Telmatobius oxycephalus. These data are compared with published descriptions of congeners. There is a considerable intraspecific osteological variation in T. oxycephalus, with cranial characters varying polymorphically, and the hyoid and postcranial characters being sexually dimorphic. This intraspecific variation is expressed by subtle differences in the degree of ossification or mineralization. Interspecific variation also can be described in terms of differential development of osteological features; these differences are more obvious than intraspecifically variable characters. The adult skeletons of several species of Telmatobius resemble the morphology observed in early stages of postmetamorphic development of T. oxycephalus. This is especially evident in the neopalatines, parasphenoid, sphenethmoid, exoccipitals, prootics, vomers, nasals, and plectra. These results suggest that within the conservative osteological architecture of Telmatobius, the variation observed is the result of heterochronic changes during the ossification process. J. Morphol. 2013. © 2012 Wiley Periodicals, Inc
Brain‐derived neurotrophic factor stimulates proliferation and differentiation of neural stem cells, possibly by triggering the Wnt/β‐catenin signaling pathway
Authors: Chen Bei‐Yu , Wang Xi , Wang Zhao‐Yan , Wang Ya‐Zhou , Chen Liang‐Wei , Luo Zhuo‐Jing 
Published: October 2012

AbstractBrain‐derived neurotrophic factor (BDNF) has critical functions in promoting survival, expansion, and differentiation of neural stem cells (NSCs), but its downstream regulation mechanism is still not fully understood. The role of BDNF in proliferation and differentiation of NSCs through Wnt/β‐catenin signaling was studied via cell culture of cortical NSCs, Western blotting, immunocytochemistry, and TOPgal (Wnt reporter) analysis in mice. First, BDNF stimulated NSC proliferation dose dependently in cultured neurospheres that exhibited BrdU incorporation and neuronal and glial differentiation abilities. Second, BDNF effectively enhanced cell commitment to neuronal and oligodendrocytic fates, as indicated by increased differentiation marker Tuj‐1 (neuronal marker), CNPase (oligodendrocyte marker), and neuronal process extension. Third, BDNF upregulated expression of Wnt/β‐catenin signaling (Wnt1 and free β‐catenin) molecules. Moreover, these promoting effects were significantly inhibited by application of IWR1, a Wnt signaling‐specific blocker in culture. The TOPgal mouse experiment further confirmed BDNF‐triggered Wnt signaling activation by β‐gal labeling. Finally, an MEK inhibition experiment showed a mediating role of the microtubule‐associated protein kinase pathway in BDNF‐triggered Wnt/β‐catenin signaling cascades. This study overall has revealed that BDNF might contribute to proliferation and neuronal and oligodendrocytic differentiation of NSCs in vitro, most possibly by triggering the Wnt/β‐catenin signaling pathway. Nevertheless, determining the exact cross‐talk points at which BDNF might stimulate Wnt/β‐catenin signaling pathway in NSC activity requires further investigation. © 2012 Wiley Periodicals, Inc.
Spatial Variability of Soil Organic C, Inorganic N and Extractable P in a Mediterranean Grazed Area
Authors: Costa C. , Papatheodorou E. M. , Monokrousos N. , Stamou G. P. 
Published: October 2012

AbstractIn this paper, we studied the spatial variability of soil organic C (SOC), inorganic N (SIN) and extractable P (Pextr) in a grazed Mediterranean‐type vegetation formation. Sampling was conducted from a gently sloping area in northern Greece.. The grazing pressure was evenly distributed over the experimental area with the exception of an overgrazed passage zone 200–300 m from steeper foothills. Soil samples, from the upper 10 cm, were collected every 10 m along four replicate lines (400 m length with a distance of 10 m between lines). Sampling took place twice (October and February). Data were analysed by geostatistical tools, and spherical models were significantly fitted to the semivariograms. SOC in both samplings and SIN in the first one displayed moderate spatial dependence which indicates the non‐random distribution of their concentration. On the contrary, Pextr and SIN in winter exhibited weak spatial dependence, whereas Pextr in autumn showed spatial independence. For the parameters exhibiting spatial pattern, two scales of dependence were revealed: a fine scale within distances shorter than 10 m and a coarse scale varying between 80 and 130 m. The coarse distribution of SOC, SIN and Pextr invoked interplay among more predictable (composition of vegetation) and unpredictable (leaching, runoff) extrinsic factors, occurring at the landscape level. Specifically, SOC as a storage agent exhibited uniform spatial pattern in both samplings. By contrast, SIN by being susceptible to leaching exhibited time‐specific dependence, whereas Pextr which was affected by surface runoff displayed limited or even spatial independence. Copyright © 2012 John Wiley & Sons, Ltd.
Federated management of the Future Internet: status and challenges
Authors: Famaey Jeroen , De Turck Filip 
Published: October 2012

SUMMARYThe Internet's original static services have been superseded by rich multimedia services with stringent end‐to‐end quality‐of‐service requirements. Additionally, there has been a trend from simple applications offered by a single provider towards service compositions, managed across the bounds of multiple domains. It is widely accepted that the end‐to‐end requirements of multimedia and composed services cannot be satisfied by the current Internet, which does not support inter‐domain collaboration. The network federation paradigm was advanced to address these limitations. It envisions the automatic negotiation and management of dynamic agreements between network domains, allowing them to collaborate to achieve goals they cannot achieve alone. This article presents an overview of state‐of‐the‐art research in the area of federated network management. Specifically, existing definitions are compared and aligned. Moreover, the most important efforts towards an architecture for a federated Future Internet are discussed. Finally, we have identified several important research challenges that need to be tackled before the federated Future Internet vision can be fully achieved. For each of these challenges, existing research efforts are surveyed and remaining open issues identified. Copyright © 2012 John Wiley & Sons, Ltd.
Inflammasomes in wound healing and fibrosis
Authors: Artlett Carol M 
Published: October 2012

AbstractInflammasome signalling and downstream cytokine responses mediated by the inflammasome have been found to play an important role, not only in wound healing but also in fibrosis. The inflammasome regulates the secretion of IL‐1β and IL‐18 cytokines, and both are critical for the repair of damaged tissue and play a role in fibrosis. However, what dictates the fine balance between normal wound healing versus fibrosis is yet to be fully elucidated. Further investigations into the role of the inflammasomes in these pathologies will be important for the discovery of novel therapeutics that can abrogate fibrosis or promote wound healing in chronic disease.Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Quality really matters: the need to improve specimen quality in biomedical research
Authors: Simeon‐Dubach Daniel , Burt Alastair D , Hall Peter A 
Published: October 2012

AbstractContemporary pathological and molecular analysis depends on high quality human biospecimens. Poor biospecimen quality may compromise such analyses and the resultant inaccurate data published in scientific papers may be contribute to low reproducibility in the biomedical literature and adversely impact clinical translation. Editors of research journals play a key role in improving sample quality in biomedical by implementing established guidelines. The Editors of Histopathology and The Journal of Pathology will now require that researchers follow the BRISQ guidelines (Biospecimen Reporting for Improved Study Quality) in their papers and hope that this will be a model adopted by other journals in this domain. Copyright © 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Characterization of composite tiles fabricated from poly(ethylene terephthalate) and micromarble particles reinforced by glass fiber mats
Authors: Icduygu M. Galip , Aktas Levent , Altan M. Cengiz 
Published: October 2012

AbstractPolyester composite tiles (PCT) are synthesized from PET and fabricated by compression molding using micromarble clusters as filler. Three batches of marble clusters with different size distributions are used to assess the effect of particle size on mechanical properties. In addition, tiles are cured at 40, 60, 80, 100, and 120°C to characterize the dependence of mechanical properties on cure temperature. Tiles prepared using finer marble grades yield consistently higher flexural strength and stiffness values regardless of the cure temperature. The cure temperature does not seem to have an appreciable effect on mechanical properties except for 120°C cure. Samples cured at 120°C registered a sharp drop in mechanical properties. Dynamic mechanical analysis indicates improved material damping when coarse grade marble dust is used. Prospects of improving mechanical properties are explored by reinforcing PC tiles with randomly oriented, discontinuous glass fibers. This is achieved by placing a single layer of glass fiber mat on the top and bottom tile surface. Presence of fiber mats leads to the formation of a graded particle size distribution across the mat thickness when the coarse grade marble dust is used. This distribution resulted in significant improvements in flexural strength, stiffness, and overall toughness of the tiles by enhancing the interfacial region between the glass mats and the PC tile. The mechanism of improvement is elaborated by studying the crack propagation and fracture morphology. POLYM. COMPOS., 33:1921–1932, 2012. © 2012 Society of Plastics Engineers