bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jet classification using high-level features from anatomy of top jets
Authors: Furuichi Amon , Lim Sung Hak , Nojiri Mihoko M. 
Published: July 2024

Abstract
Recent advancements in deep learning models have significantly enhanced jet classification performance by analyzing low-level features (LLFs). However, this approach often leads to less interpretable models, emphasizing the need to understand the decision-making process and to identify the high-level features (HLFs) crucial for explaining jet classification. To address this, we consider the top jet tagging problems and introduce an analysis model (AM) that analyzes selected HLFs designed to capture important features of top jets. Our AM mainly consists of the following three modules: a relation network analyzing two-point energy correlations, mathematical morphology and Minkowski functionals for generalizing jet constituent multiplicities, and a recursive neural network analyzing subjet constituent multiplicity to enhance sensitivity to subjet color charges. We demonstrate that our AM achieves performance comparable to the Particle Transformer (ParT) while requiring fewer computational resources in a comparison of top jet tagging using jets simulated at the hadronic calorimeter angular resolution scale. Furthermore, as a more constrained architecture than ParT, the AM exhibits smaller training uncertainties because of the bias-variance tradeoff. We also compare the information content of AM and ParT by decorrelating the features already learned by AM. Lastly, we briefly comment on the results of AM with finer angular resolution inputs.
Minimal complete tri-hypercharge theories of flavour
Authors: Fernández Navarro Mario , King Stephen F. , Vicente Avelino 
Published: July 2024

Abstract
The tri-hypercharge proposal introduces a separate gauged weak hypercharge assigned to each fermion family as the origin of flavour. This is arguably one of the simplest setups for building “gauge non-universal theories of flavour” or “flavour deconstructed theories”. In this paper we propose and study two minimal but ultraviolet complete and renormalisable tri-hypercharge models. We show that both models, which differ only by the heavy messengers that complete the effective theory, are able to explain the observed patterns of fermion masses and mixings (including neutrinos) with all fundamental coefficients being of $$ \mathcal{O} $$
O
(1). In fact, both models translate the complicated flavour structure of the Standard Model into three simple physical scales above electroweak symmetry breaking, completely correlated with each other, that carry meaningful phenomenology. In particular, the heavy messenger sector determines the origin and size of fermion mixing, which controls the size and nature of the flavour-violating currents mediated by the two heavy Z′ gauge bosons of the theory. The phenomenological implications of the two minimal models are compared. In both models the lightest Z′ remains discoverable in dilepton searches at the LHC Run 3.
Not all that is β0 is β-function: the DGLAP resummation and the running coupling in NLO JIMWLK
Authors: Kovner Alex , Lublinsky Michael , Skokov Vladimir V. , Zhao Zichen 
Published: July 2024

Abstract
We reanalyze the origin of the large transverse logarithms associated with the QCD one loop β function coefficient in the NLO JIMWLK Hamiltonian. We show that some of these terms are not associated with the running of the QCD coupling constant but rather with the DGLAP evolution. The DGLAP-like resummation of these logarithms is mandatory within the JIMWLK Hamiltonian, as long as the color correlation length in the projectile is larger than that in the target. This regime in fact covers the whole range of rapidities at which JIMWLK evolution is supposed to be applicable. We derive the RG equation that resums these logarithms to all orders in αs in the JIMWLK Hamiltonian. This is a nonlinear equation for the eikonal scattering matrix S(x). We solve this equation, and perform the DGLAP resummation in two simple cases: the dilute limit, where both the projectile and the target are far from saturation, and the saturated regime, where the target correlation length also determines its saturation momentum.
Pions from higher-dimensional gluons: general realizations and stringy models
Authors: Dong Jin , Li Xiang , Zhu Fan 
Published: July 2024

Abstract
In this paper we revisit the general phenomenon that scattering amplitudes of pions can be obtained from “dimensional reduction” of gluons in higher dimensions in a more general context. We show that such “dimensional reduction” operations universally turn gluons into pions regardless of details of interactions: under such operations any amplitude that is gauge invariant and contains only local simple poles becomes one that satisfies Adler zero in the soft limit. As two such examples, we show that starting from gluon amplitudes in both superstring and bosonic string theories, the operations produce “stringy” completion of pion scattering amplitudes to all orders in α′, with leading order given by non-linear sigma model amplitudes. Via Kawai-Lewellen-Tye relations, they give closed-stringy completion for Born-Infeld theory and the special Galileon theory, which are directly related to gravity amplitudes in closed-string theories. We also discuss how they naturally produce stringy models for mixed amplitudes of pions and colored scalars.
Ultrasound-assisted synthesis of 4-thiazolidinone Schiff bases and their antioxidant, α-glucosidase, α-amylase inhibition, mode of inhibition and computational studies
Authors: Seboletswe Pule , Kumar Gobind , Kubone Lungisani , Olofinsan Kolawole , Idris Almahi , Islam Md. Shahidul , Singh Parvesh 
Published: July 2024

AbstractDiabetes mellitus (DM) has become a growing concern to global public health, being at the forefront of acute disorders and causes of mortality across the globe. Clinically approved drugs that are currently being used are faced with severe side effects, consequently necessitating the development of new drugs with no/fewer side effects and improved pharmacological potency. Herein, we report a rapid and efficient synthesis of thiazolidinone Schiff bases (2a-2t) from benzylidenehydrazines and thioglycolic acid under neat conditions through ultra-sonication. All the synthesized compounds were obtained in exceptional yields (89–95%) and confirmed by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, as well as High-resolution mass spectrometry (HRMS). The synthesized compounds were then evaluated for their antidiabetic activity through α-glucosidase and α-amylase inhibitory potentials and their antioxidant activity through Nitric Oxide (NO), 2,2′-diphenyl-1-picrylhydrazyl (DPPH), and Ferric reducing antioxidant power (FRAP) assays. Among them, 2q (IC50 = 96.63 μM) and 2h (IC50 = 125.27 μM) emerged as the most potent derivatives against α-amylase relative to reference drug acarbose (IC50 = 131.63 µM), respectively. Antioxidant evaluation further revealed that the synthesized derivatives were excellent NO scavengers disclosing 2n (IC50 = 44.95 µM) as the most potent derivative. Moreover, in silico ADME calculations predicted these compounds to have excellent drug-like properties. Kinetic studies disclosed the mode of α-amylase inhibition as competitive while molecular docking studies of the most active derivatives performed into the binding active site of human pancreatic α-amylase enzyme deciphered their ligand-protein interactions that explicated their observed experimental potencies.
Survival among 148 patients with an incidentally detected appendiceal tumours at surgery for acute appendicitis: a population-based cohort follow-up study
Authors: Boström Lennart , Jovic Viktor , Dahlberg Martin , Holtenius Fredrik , Sandblom Gabriel , Järnbert-Pettersson Hans 
Published: July 2024

Abstract
Purpose
To investigate the long-term prognosis of appendiceal tumours incidentally detected at appendicectomy for suspicion of benign appendicitis.

Methods
A retrospective register-based single centre cohort study was carried out, using data from the local acute appendicectomy quality register of cases operated on at the Department of Surgery, South General Hospital, Stockholm, Sweden. The local colorectal cancer register was also used to identify appendix tumours. The study period was between January 2004 and January 2023. Survival was calculated according to the Kaplan-Meier method.

Results
A total of 11,888 patients were registered in the acute acute appendicectomy register, 54% males and 46% females, median age 32 (Q1 = 21, Q3 = 47) (with 33.7% were 41 years or older). From the appendicectomy and colorectal registers 148 (1.2% of the total cohort) appendiceal tumours were found; 60% in females and 40% in males, median age 56 (Q1 = 43, Q3 = 70) (with 78.4% being 41 years or older). Tumours found were: Low grade Appendiceal Mucinous Neoplasms (LAMN, N = 64); Neuroendocrine Tumours (NET N = 24); adenocarcinomas or other form of carcinomas (N = 57); and adenomas (N = 3). The overall 5-year survival in patients operated for LAMN was 96.8%, for NET 93.3% and for adenocarcinoma 69.7%. The overall 5-year survival for all tumour patients was 85.7%. For the younger patients (< 51 years) with LAMN and NET, almost all survived to the end of follow-up. Survival of patients in the carcinoma group was statistically significantly lower than for the LAMN and NET groups, especially in females 51 years or older. In the group of tumour patients undergoing surgery (n = 146), primary surgery was laparoscopic in 47% and open in 52%. Two patients did not undergo surgery due to widespread disease. In 64% of cases operation was acute, whereas it was delayed and/or planned in 34%. Most procedures were laparoscopic appendicectomy 36%, followed by open appendicectomy 30%, right-sided hemicolectomy 14.6% (open 11.6% and laparoscopic 3%, acute operation 5.5%), ileocaecal resection 5% (acute operation 3.4%), and staging laparoscopy 7%. In 38% of the operated patients the tumour was discovered incidentally at histopathology examination. Two patients had CRS and HIPEC as the initial operation. Forthy-three per cent of the 146 tumour patients operated underwent a second procedure: CRS and HIPEC in 23.3% and right-sided hemicolectomy in 13.6% (laparoscopic 8.2% open 5.4%).

Conclusion
Survival was high for patients with incidentally detected appendiceal LAMN or NET, but not so for carcinoma. Survival was lower in the carcinoma group older than 50 years, especially those sick and females.
Use of antibiotics in the early COVID-19 pandemic in Poland, the Netherlands and Spain, from erraticism to (more) logic
Authors: Opalska Aleksandra , Gardarsdottir Helga , Kwa Marcel , Wójkowska-Mach Jadwiga , Sabate Monica , Ballarin Maria Elena , de Groot Mark , Leufkens Hubert 
Published: July 2024

Abstract
Introduction
In the Spring of 2020, the world was hit with unparalleled impact by the coronavirus pandemic. Antibiotics were widely used, even without good rationale. The aim of our study was to compare the use of antibiotics in patients with confirmed COVID-19 from three hospitals across Europe (Poland, the Netherlands and Spain) between two subsequent periods in the early days of the pandemic.

Method
We analysed data (antibiotics used and variation in the use of antibiotics, patients, admission and disease-related characteristics) from 300 patients admitted in three hospitals (University Hospital in Cracow, University Medical Center in Utrecht and Vall d’Hebron University Hospital in Barcelona) with confirmed infection of SARS-CoV-2 during Q1 2020 and Q4 2020.

Results
There was ample variation in terms of patient mix and outcomes across the 3 hospitals. The majority of patients (225 out of 300) in all 3 hospitals received at least 1 antibiotic during the hospitalisation period. A minority of patients (68 out of 300) had their bacterial test results positive during their hospitalisation period. Throughout the 2 study periods, third-generation cephalosporins (ceftriaxone in 170 out of 300 patients) emerged as the most commonly used class of antibiotics. There was an apparent shift towards more rational utilisation of antibiotics, in all three hospitals.

Conclusions
Our study shows that during the early stage of COVID-19 pandemic in 2020, antibiotics were frequently used in three European teaching hospitals despite the relatively low incidence of microbiologically confirmed bacterial infections. While in the early days of the COVID-19 pandemic antibiotic prescribing was full of trial and error, we could also confirm a learning curve over time.
Magnetic resonance imaging radiomics-based prediction of severe inflammatory response in locally advanced rectal cancer patients after neoadjuvant radiochemotherapy
Authors: Chen Li , Zhu Wenchao , Zhang Wei , Chen Engeng , Zhou Wei 
Published: July 2024

Abstract
Purpose
To predict severe inflammatory response after neoadjuvant radiochemotherapy in locally advanced rectal cancer (RC) patients using magnetic resonance imaging (MRI) radiomics models.

Methods
This retrospective study included patients who underwent radical surgery for RC cancer after neoadjuvant radiochemotherapy between July 2017 and December 2019 at XXX Hospital. MRI radiomics features were extracted from T2WI images before (pre-nRCT-RF) and after (post-nRCT-RF) neoadjuvant radiochemotherapy, and the variation of radiomics features before and after neoadjuvant radiochemotherapy (delta-RF) were calculated. Eight, eight, and five most relevant features were identified for pre-nRCT-RF, post-nRCT-RF, and delta-RF, respectively.

Results
Eighty-six patients were included and randomized 3:1 to the training and test set (n = 65 and n = 21, respectively). The prediction model based on delta-RF had areas under the curve (AUCs) of 0.80 and 0.85 in the training and test set, respectively. A higher rate of difficult operations was observed in patients with severe inflammation (65.5% vs. 42.9%, P = 0.045).

Conclusion
The prediction model based on MRI delta-RF may be a useful tool for predicting severe inflammatory response after neoadjuvant radiochemotherapy in locally advanced RC patients.
Ethische Dilemmata in der Neurologie bei Sterbeverfügungen
Authors: Novak Helmut F. 
Published: July 2024

ZusammenfassungSeit Inkrafttreten des Sterbeverfügungsgesetzes (StVerfG) in Österreich hat sich im ASCIRS-Register der Österreichischen Palliativgesellschaft (OPG) ein Anteil von 25 % bei neurologischen Erkrankungen abgebildet. Das unterstreicht einerseits deren besondere Bedeutung für die Errichtung einer Sterbeverfügung, begründet aber auch eine besondere Verantwortung der Neurolog:innen, auch wenn sie dadurch an ihre ethischen Grenzen stoßen und in Dilemmata bei Entscheidungen zwischen Neuropalliation und Sterbewilligkeit geraten. Dennoch benötigen gerade Patient:innen mit chronischen neurologischen Erkrankungen eine fachneurologische Begleitung bis zum Lebensende, einschließlich der Beratung für eine krankheitsspezifische Patientenverfügung und der Betreuung der Angehörigen nach einer assistierten Selbsttötung.
Assessing the viability of parking slot utilization as transhipment points for parcel carriers: a case study in Barcelona
Authors: Savall-Mañó Maria , Ribas Imma 
Published: July 2024

AbstractThe measures proposed in the sustainable and smart mobility strategy developed by the European commission are crucial for achieving the environmental objectives for 2030. This strategy includes measures specifically aimed at reducing the impact of e-commerce distribution. One widely adopted strategy for mitigating the impact of e-commerce distribution is the establishment of urban consolidation centres (UCCs). While this infrastructure quickly demonstrates its environmental success in urban areas, achieving long-term economic sustainability proves challenging. In this paper, we introduce a methodology aimed at incentivizing parcel carriers to shift towards an economically feasible and environmentally sustainable distribution mode within urban areas by leveraging their own transhipment space. This methodology includes a mathematical program for determining the quantity and locations of parking slots, taking into account the number of parcels and transportation vehicles used. It also utilizes the Continuous Approximation technique to assess the transportation and environmental costs of the proposed solutions. The proposed methodology is implemented for the city of Barcelona, considering three different sizes of parcel carriers: the carrier handling the largest volume of parcels, the carrier handling the lowest volume of parcels, and an intermediate case. The vehicles considered for delivery from the transhipment points include vans, cargo bikes, and trolleys for distribution on foot. The results indicate that a significant reduction in both transport and environmental costs is achieved when using zero-emissions vehicles for delivery from transhipment points for any of the parcel carriers considered.
US & MR/CT Image Fusion with Markerless Skin Registration: A Proof of Concept
Authors: Paccini Martina , Paschina Giacomo , De Beni Stefano , Stefanov Andrei , Kolev Velizar , Patanè Giuseppe 
Published: July 2024

Abstract
This paper presents an innovative automatic fusion imaging system that combines 3D CT/MR images with real-time ultrasound acquisition. The system eliminates the need for external physical markers and complex training, making image fusion feasible for physicians with different experience levels. The integrated system involves a portable 3D camera for patient-specific surface acquisition, an electromagnetic tracking system, and US components. The fusion algorithm comprises two main parts: skin segmentation and rigid co-registration, both integrated into the US machine. The co-registration aligns the surface extracted from CT/MR images with the 3D surface acquired by the camera, facilitating rapid and effective fusion. Experimental tests in different settings, validate the system’s accuracy, computational efficiency, noise robustness, and operator independence.
Beyond reasonable doubt: reconsidering Neanderthal aesthetic capacity
Authors: Meneganzin Andra , Killin Anton 
Published: July 2024

AbstractAn aesthetic sense—a taste for the creation and/or appreciation of that which strikes one as, e.g., attractive or awesome—is often assumed to be a distinctively H. sapiens phenomenon. However, recent paleoanthropological research is revealing its archaeologically visible, deeper roots. The sensorimotor/perceptual and cognitive capacities underpinning aesthetic activities are a major focus of evolutionary aesthetics. Here we take a diachronic, evolutionary perspective and assess ongoing scepticism regarding whether, and to what extent, aesthetic capacity extends to our evolutionary cousins, the Neanderthals. The goal of this article is twofold. First, it serves as a defence of the attribution of Neanderthal aesthetic capacity by marshalling archaeological data best explained by positing a Neanderthal aesthetic sense. Second, it offers an opportunity to make progress on understanding some epistemically relevant features of the wider debate in evolutionary aesthetics. First, we outline and analyse a range of distinct ‘sceptical arguments’ derived from attitudes and claims found in the literature and broader debate that aim to dial down the case for Neanderthal aesthetic capacity. We show that these arguments not only miss their target, they divert the debate away from more compelling questions. We then consider the case for protoaesthetic capacities and sensitivities in the Acheulean stone tool industry and argue that Neanderthals likely inherited the protoaesthetic package from ancient ancestors that they shared with H. sapiens. Finally, we sketch and defend a research agenda for framing Neanderthal aesthetic niche(s) beyond H. sapiens-derived standards, which we see as a priority for future archaeological, cognitive, and philosophical research. While we resist sceptical arguments and the often-implied inferiority of Neanderthals to humans, we also deny that Neanderthals and ancient humans were indistinguishable. Understanding the differences is an important goal of interpretation, and we apply this line of reasoning to the case of aesthetics.
TiO2/Al-PILC Catalysts Synthesized from a Non-Conventional Aluminum Source of Aluminum and Applied in the Photodegradation of Organic Compounds
Authors: Cardona Yaneth , Gil Antonio 
Published: July 2024

Abstract
This study explores the transformative potential of Pillared InterLayered Clays (PILC) derived from non-conventional aluminum sources as catalytic supports in the synthesis of TiO2/catalysts for the efficient photodegradation of organic pollutants in water. Montmorillonite (Mt) and three alumina-pillared montmorillonite (PILC) synthesized using various aluminum sources, were impregnated with titanium to synthesize TiO2/catalysts. The successful synthesis of these materials was confirmed through several characterization techniques such as X-ray diffraction (XRD), N2 adsorption-desorption at -196 ºC, morphological analysis using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and Energy-Dispersive X-ray Spectrometry (EDX). The photolysis, adsorption, and catalytic behavior of the TiO2/catalysts were studied for the degradation of triclosan (TCS), 2,6-dichlorophenol (2,6-DCP), and bisphenol A (BPA). All synthesized catalysts surpassed the efficacy of commercial anatase, with TiO2/Al-PILC exhibiting superior performance in comparison to TiO2/Mt. Photodegradation was most effective under UV radiation, with TCS demonstrating the highest degradation (approximately 70%). Notably, Al-PILC samples, particularly those synthesized from saline slags, displayed enhanced properties. Among them, TiO2/Al-PILCAE exhibited the highest degradation rates under both UV and visible light, underlining the remarkable potential of saline slags as precursors for Al-PILC synthesis. This study provides valuable insights into the design and development of efficient catalysts for water treatment applications, paving the way for sustainable and effective solutions in the realm of environmental remediation.
Delta radiomics: an updated systematic review
Authors: Nardone Valerio , Reginelli Alfonso , Rubini Dino , Gagliardi Federico , Del Tufo Sara , Belfiore Maria Paola , Boldrini Luca , Desideri Isacco , Cappabianca Salvatore 
Published: July 2024

Abstract
Background
Radiomics can provide quantitative features from medical imaging that can be correlated with various biological features and diverse clinical endpoints. Delta radiomics, on the other hand, consists in the analysis of feature variation at different acquisition time points, usually before and after therapy. The aim of this study was to provide a systematic review of the different delta radiomics approaches.

Methods
Eligible articles were searched in Embase, Pubmed, and ScienceDirect using a search string that included free text and/or Medical Subject Headings (MeSH) with 3 key search terms: 'radiomics,' 'texture,' and 'delta.' Studies were analyzed using QUADAS-2 and the RQS tool.

Results
Forty-eight studies were finally included. The studies were divided into preclinical/methodological (5 studies, 10.4%); rectal cancer (6 studies, 12.5%); lung cancer (12 studies, 25%); sarcoma (5 studies, 10.4%); prostate cancer (3 studies, 6.3%), head and neck cancer (6 studies, 12.5%); gastrointestinal malignancies excluding rectum (7 studies, 14.6%) and other disease sites (4 studies, 8.3%). The median RQS of all studies was 25% (mean 21% ± 12%), with 13 studies (30.2%) achieving a quality score < 10% and 22 studies (51.2%) < 25%.

Conclusions
Delta radiomics shows potential benefit for several clinical endpoints in oncology, such asdifferential diagnosis, prognosis and prediction of treatment response, evaluation of side effects. Nevertheless, the studies included in this systematic review suffer from the bias of overall low methodological rigor, so that the conclusions are currently heterogeneous, not robust and hardly replicable.
Further research with prospective and multicenter studies is needed for the clinical validation of delta radiomics approaches.