bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pembuatan Batik Ecoprint Sebagai Upaya Implementasi Industri Hijau
Authors: Zutiasari Ika , Rahayu Wening Patmi , Fitri Raisa , Agnesia Rila Ayu , Zumroh Siti 
Published: July 2024

Ecoprint merupakan salah satu teknik pewarnaan kain yang saat ini sedang trend dikalangan pelaku usaha busana dan pengrajin tekstil. Dengan memanfaatkan bahan-bahan alami yang mudah diperoleh dan ramah lingkungan, maka ecoprint ini menjadi salah satu peluang usaha busana. Kegiatan ini dilakukan di lapas perempuan Malang, dimana kesediaan SDM berlimpah di lokasi. Berdasarkan analisis kebutuhan, perlu berbagai kegiatan untuk meningkatkan keterampilan warga binaan yang sekaligus dapat menghasilkan produk yang memiliki nilai ekonomis yang tinggi. Kegiatan yang dilakukan tim yaitu memberikan edukasi terkait pengenalan batik ecoprint. Peserta mengikuti sesi penyampaian materi hingga selesai. Materi harus dipahami sebagai dasar atau wawasan untuk praktik baik membuat batik ecoprint yang baik dan benar. Kegiatan selanjutnya adalah praktik pembuatan batik menggunakan teknik ecoprint. Pada saat pelaksanaan kegiatan, seluruh peserta melaksanakan praktik langsung bersama dengan tenaga ahli yang mendampingi para peserta. Program ini memberikan dampak positif diantaranya, bagi warga binaan untuk menambah keterampilan yang dapat mereka manfaatkan setelah membaur kembali di lingkungan masyarakat. dampak lainnya kegiatan ini yaitu bentuk pelestarian terhadap lingkungan dengan memanfaatkan bahan-bahan dasar batik yang ramah lingkungan. Kata kunci— Batik, Ecoprint, Industri hijau, Warga binaan Abstract Ecoprint is one of the fabrics dyeing techniques that is currently trending among fashion businesses and textile craftsmen. By utilizing natural materials that are easily obtained and environmentally friendly, this eco-print becomes one of the fashion business opportunities. This activity was carried out in Malang women's prison, where human resources were abundant. Based on the needs analysis, various activities are needed to improve the skills of fostered citizens who can, at the same time, produce products that have high economic value. The activities carried out by the team are providing education related to the introduction of ecoprint batik. Participants attended the material delivery session to completion. The material must be understood as a basis or insight for good practices (best practice) in making excellent and correct ecoprint batik. The next activity is the practice of making batik using ecoprint techniques. During the implementation of the activity, all participants carry out direct practice together with experts accompanying the participants. This program has a positive impact, among others, for fostered residents to increase skills they can use after reintegrating into the community. Another impact of this activity is a form of preservation of the environment by utilizing basic materials of environmentally friendly batik. Keywords—Batik, Ecoprint, Green industry, Fostered citizens
Evolución de las reivindicaciones de mujeres en España. De lo normativo a lo social
Authors: Pérez González Beatriz , Rodríguez Penin Ana 
Published: July 2024

La historia reciente en España de las reivindicaciones de las mujeres por la igualdad, tiene rasgos específicos y un recorrido arrítmico e irregular. El artículo expone el proceso de la II República a nuestros días, mostrando los avances y resistencias, planteando la transformación actual en la tipología de las reivindicaciones y luchas. La hipótesis de trabajo es que desde ese periodo a nuestros días las reivindicaciones han pasado de una mayor incidencia en lo normativo (según las posibilidades) a una transformación y configuración como movimiento de mujeres. Las reivindicaciones de mujeres y los avances más significativos, son objeto de estudio al representar una transformación en formas de actuación, alianzas y tipos de luchas en la actualidad.
Sugar addiction and its role in obesity among adolescents residing in an urban field practice area of Bagalkot: A cross-sectional study
Authors: Kanyadi Suhasini R , Gadi Nabeel Ahmed , Kulkarni Kalpana 
Published: July 2024

Obesity, a multi-factorial process is showing an increasing trend among children and adolescents leading to increased prevalence of insulin resistance, paving the way for cardio-metabolic risk factors. It has been proposed that certain food items as well as eating habits are addictive in a way that is similar to substances of abuse. Thus, this study was conducted among adolescents to determine the frequency of sugar addiction, the influencing factors and its association with obesity. A cross-sectional study was designed and 250 late adolescents (17–19 years old) chosen from colleges coming under urban field practice area of Bagalkot were enrolled in the study. A self-administered questionnaire which consisted of three sections - socio-demographic details, validated Modified Yale Food Addiction Scale (mYFAS) and Physical Activity Questionnaire for Adolescents (PAQ-A) was used to collect data regarding sugar addiction and physical activity in our study. Sugar addiction was found among 7.6%of adolescents and it was associated with overweight and obesity which was statistically significant (X=42.72, p&#60;0.0001). Factors which significantly contributed to sugar addiction among adolescents were; adolescents staying in hostel (p&#60;0.001), working mother’s (p&#60;0.0001) and socio-economic status (p=0.02). Univariate analysis (unadjusted odds ratio) showed that risk factors such as sugar addiction (Odds ratio 9.6, 95% C.I. 2.18-42.8, p=0.003) and reduced physical activity (Odds ratio 3.8, 95% C.I. 2.02-7.26, p=0.0001) were associated with overweight and obesity.Incorporation of measures against hyper palatable sugary foods into public health policy recommendations and a further detailed evaluation regarding sugar addiction may provide a new insight and help in prevention and treatment of obesity.
Pituitary neuroadenoma as an ‘Incidentaloma’ in a case of road traffic accident
Authors: Devaraj Boddepalli , Rupesh Kattamreddy Ananth , Vavilapalli Srinivasarao , Allu Jitendra Durga Kanna 
Published: July 2024

: Pituitary adenomas are the most common tumors found in the Sella region. Functional pituitary adenomas exhibit a wide range of endocrine manifestations due to either hypo- or hyperfunction of the pituitary gland, as well as mass effect. They can have a slow but severe impact on vision due to compression of the optic nerves, optic chiasm and cavernous sinus.: A 42-year-old male, a security guard at a local dabha, was struck by a van while crossing the road. He sustained a head injury and unfortunately passed away during treatment at our tertiary case institute. At autopsy, upon examination of the skull, a mass measuring 5x5x3cm was discovered in the suprasellar area of base of skull. This mass was sent for histopathological examination, which confirmed it to be a "Pituitary neuroendocrine tumor possibly gonadotropic in nature." However, the cause of death in this case was opined as ‘Head injury’.: Forensic pathologists rarely encounter intracranial neoplasms that present as sudden and unexpected deaths. The incidence of undiagnosed fatal brain tumors detected at autopsy has been reported to range between 0.02% and 0.4%. Several studies have investigated the relationship between hormonally active pituitary adenomas and both mental health disorders and quality of life. One study by Johnson et al. found that patients with nonfunctional adenomas reported impairments in physical and emotional well-being compared to the normal population. Headache and visual symptoms are most commonly associated with pituitary adenomas.In the present case, although it was an incidental finding and not contributing to the cause of death, we cannot underestimate the effect of the tumor on the visual acuity of the decedent. Nonetheless, visual impairment due to the tumor could also have partially led to the road traffic accident.
Educação para Era Digital: Desafios dos Professores no Uso das Tecnologias Digitais no Ensino Médio
Authors: Sandes Elizane Mouzinho da Silva , Sobrinho Oswaldo Palma Lopes , Coelho Brenda Abigail Freire de Jesus , Mendes Lise Mary Ferreira , Rezende Laila Francielly , Pereira Netília Vieira , Sateles Glaucinéia Antônia de 
Published: July 2024

As Tecnologias Digitais da Informação e Comunicação (TDIC) são importantes ferramentas que vêm evoluindo ao longo dos tempos, no meio educacional têm se tornado um importante recurso metodológico, inovando o sistema de ensino. Diante disso, o objetivo deste estudo foi analisar a prática docente no Ensino Médio quanto à utilização das Tecnologias Digitais da Informação e Comunicação como recursos didáticos-pedagógicos em sala de aula. Realizou-se a pesquisa de natureza qualitativa, caracterizada como um estudo de caso, onde os dados foram coletados por meio da aplicação do questionário semiestruturado a seis professores/as de uma escola pública, localizada num município do Estado do Maranhão, Brasil. A análise dos dados seguiu os princípios da Análise de Conteúdo proposta por Bardin (2019). Os resultados indicam haver um esforço por parte dos professores/as em tentar fazer uso das TDIC, na prática docente mesmo não tendo habilidades e ferramentas digitais suficientes. Diante disso, ver-se a necessidade de implantação de políticas públicas que promovam atividades que auxiliem o docente e a sua formação para o uso das tecnologias digitais, de maneira inovadora, cabível, e principalmente eficaz à educação de qualidade.

Palavras-chave: Educação básica. Prática docente. Recursos tecnológicos.
Роль системы адаптивной физической культуры и адаптивного спорта в социальной адаптации лиц с ограниченными возможностями здоровья: опыт Белгородской области
Authors: Стрижакова Елена Владимировна , Климова Виктория Константиновна , Шимохина Мария Валерьевна 
Published: July 2024

Вовлечение лиц с отклонениями в состоянии здоровья и инвалидов в занятия адаптивной физической культурой и спортом способствует облегчению процессов адаптации в социуме, повышает самооценку занимающихся.
В Белгородской области приоритетным направлением является внедрение социально ориентированных технологий улучшения качества жизни людей данной категории. Приводятся данные, подтверждающие повышение вовлеченности лиц с ОВЗ в активные занятия физкультурно-оздоровительной направленности.
Рассматривается единая концепция реализации комплекса мер и физкультурно-оздоровительных услуг («дорожная карта»), направленных на развитие адаптивной физической культуры и спорта в муниципальных образованиях области.
Attenuation of Cadmium Toxicity by Methanol Extracts of Rauvolfia vomitoria and Aframomum melegueta leaves
Authors: Adeniyi Temidayo , Akinpelu Moronkeji , Omokehinde Akinlami  , Molade James Kolawole  , Jesufemi Oloye  , Akogun Imoleayo 
Published: July 2024

Highlights:1. This study provides insight into the detrimental effect of cadmium exposure on mammalian cells using a murine model.2. The co-administration of Rauvolfia vomitoria and Aframomum melegueta leaf extracts is more effective in ameliorating cadmium-induced toxicity than a single administration of each plant extract.3. The co-administration of Rauvolfia vomitoria and Aframomum melegueta plant extracts can upregulate the expression of IL-10 and reverse the derangements in the TNF-Î±, IL-6, SOD, and GPX levels.

Abstract
Cadmium has long been known to be an environmental pollutant that can harm human health, with toxicity majorly affecting the kidneys and liver. This study aimed to investigate the mitigating potential of methanol extracts of Rauvolfia vomitoria and Aframomum melegueta leaves in cadmium-induced liver toxicity. Twenty-five male adult Wistar rats, averagely weighing 200 g, were randomly allocated into five groups, each comprising five rats. Group 1 was unexposed to any substances and only received distilled water. Group 2 was given cadmium at a standard dose of 12 mg/kg bw. Groups 3, 4, and 5 received 12 mg/kg bw of cadmium, and each group was treated with 200 mg/kg bw of Rauvolfia vomitoria leaf extract, Aframomum melegueta leaf extract, and a combination of both extracts, respectively. After 28 days, the animals were euthanized to obtain their livers, which were then excised and processed for histopathological, mRNA expression, and biochemical analyses. A one-way analysis of variance (ANOVA) was used to analyze the data, and Duncan multiple tests were employed to compare the categorical variables (p<0.05). The results revealed elevated levels of interleukin 10 (IL-10) in the rats treated with Rauvolfia vomitoria and Aframomum melegueta extracts when compared to Group 2. On the other hand, the treatment groups exhibited a significant decrease in tumor necrosis factor alpha (TNF-Î±) and interleukin 6 (IL-6) levels, along with significantly elevated levels of superoxide dismutase (SOD) and glutathione peroxidase (GPx). Group 5 showed a normal liver histoarchitecture similar to Group 1, reversing the histopathological abnormalities shown in Group 2. In conclusion, the co-administrative treatment using Rauvolfia vomitoria and Aframomum melegueta extracts reversed the cadmium-induced toxicity better than using each plant extract individually. This further suggests that Rauvolfia vomitoria and Aframomum melegueta leaf methanol extracts may ameliorate the effects of cadmium-induced toxicity, including reducing oxidative stress and fortifying the anti-oxidant system.
Dramatic impact of blood collection tube and RNA purification method on extracellular RNA transcriptomes
Authors: Vandesompele Jo , Anckaert Jasper , Cobos Francisco Avila , De preter Katleen , de wever olivier , De Wilde Jilke , Decock Anneleen , Decruyenaere Philippe , Deleu Jill , Dhondt Bert , D'huyvetter Thibaut , Everaert Celine , Fierro Carolina , Hendrix An , Helsmoortel Hetty , Hulstaert Eva , Koster Jan , Kuersten Scott , Mercer Timothy , Mestdagh Pieter , Morlion Annelien , Nijs Nele , Nuytens Justine , Philippron Annouck , Piofczyk Thomas , Poma-Soto Franco , Schoofs Kathleen , Schroth Gary , Thas Olivier , Maerken Tom Van , Paemel Ruben Van , Eynde Eveline Vanden , Verniers Kimberly , Verwilt Jasper , Yigit Nurten 
Published: July 2024

Abstract

The use of blood-based extracellular RNA (cell-free RNA; exRNA) as clinical biomarker requires the implementation of a validated procedure for sample collection, processing, and profiling. So far, no study has systematically addressed the pre-analytical variables affecting transcriptome analysis of exRNAs. In the exRNAQC study, we evaluated ten blood collection tubes, three time intervals between blood draw and downstream processing, and eight RNA purification methods using the supplier-specified minimum and maximum biofluid input volumes. The impact of these pre-analytics on deep transcriptome profiling of both small and messenger RNA from healthy donors' plasma or serum was assessed for each pre-analytical variable separately and for interactions between a selected set of pre-analytics, resulting in 456 extracellular transcriptomes. Making use of 189 synthetic spike-in RNAs, the processing and analysis workflow was controlled. When comparing blood collection tubes, so-called preservation tubes do not stabilize exRNA well, and result in variable RNA concentration and sensitivity (i.e., the number of detected RNAs) over time, as well as compromised reproducibility. We also document large differences in RNA purification kit performance in terms of sensitivity, reproducibility, and observed transcriptome complexity, and demonstrate interactions between specific blood collection tubes, purification kits and time intervals. Our results are summarized in 11 performance metrics that enable an informed selection of the most optimal sample processing workflow for a given experiment. In conclusion, we put forward robust quality control metrics for exRNA quantification methods with validated standard operating procedures (SOPs), representing paramount groundwork for future exRNA-based precision medicine applications.
Investigating the Relationship Between Gut Microbiota and Ischemic Stroke: Genetic Causality and Metabolite Mediation
Authors: Ye Liya , Yu Gang , Shen Jing , Cai Hui 
Published: July 2024

Abstract

Background
The gut microbiota(GM) plays a significant role in health and disease, with numerous studies confirming its association with various diseases. This study aims to evaluate the genetic causal relationship between GM and ischemic stroke (IS), along with exploring potential blood metabolite-mediated mechanisms.
Methods
Utilizing two-sample Mendelian Randomization (MR) and large-scale Genome-Wide Association Studies (GWAS) data, we investigate the association between GM and IS. Bayesian Weighted MR (BWMR) is employed for validation, and genetic correlations are assessed using Bivariate Linkage Disequilibrium Score Regression (LDSC) and Genetic Analysis Incorporating Pleiotropy and Annotation (GPA).
Results
Our analysis using Inverse Variance Weighted (IVW) method indicates that specific microbial groups, such as genus Ruminiclostridium and order Burkholderiales, are significantly associated with IS risk. Mediation analysis suggests that metabolites like Pyruvate, Arachidonate, and HDL-related lipoproteins may mediate this relationship. Multivariate MR analysis confirms the independence of these mediating effects. Furthermore, both LDSC and GPA analyses demonstrate significant genetic correlations between GM and IS.
Conclusion
Through the integration of various statistical methods and GWAS data, this study provides genetic evidence supporting the causal relationship between GM and IS, uncovering potential biological mediating mechanisms. These findings enhance our understanding of the GM's role in cardiovascular and cerebrovascular diseases, offering insights into preventive and treatment strategies.
Mugen-UMAP: UMAP visualization and clustering of mutated genes in single-cell DNA sequencing data
Authors: Li Teng , Zou Yiran , Li Xianghan , Wong Thomas K. F. , Rodrigo Allen 
Published: July 2024

Abstract

Background
The application of Uniform Manifold Approximation and Projection (UMAP) for dimensionality reduction and visualization has revolutionized the analysis of single-cell RNA expression and population genetics. However, its potential in single-cell DNA sequencing data analysis, particularly for visualizing gene mutation information, has not been fully explored.
Results
We introduce Mugen-UMAP, a novel Python-based program that extends UMAP's utility to single-cell DNA sequencing data. This innovative tool provides a comprehensive pipeline for processing gene annotation files of single-cell somatic single-nucleotide variants and metadata to the visualization of UMAP projections for identifying clusters, along with various statistical analyses. Employing Mugen-UMAP, we analyzed whole-exome sequencing data from 365 single-cell samples across 12 non-small cell lung cancer (NSCLC) patients, revealing distinct clusters associated with histological subtypes and uncovering patterns of gene mutation that suggest a deeper insight into tumor heterogeneity and evolution.
Conclusions
The application of Mugen-UMAP demonstrates its capacity to provide valuable insights into the visualization and interpretation of single-cell DNA sequencing data. Mugen-UMAP can be found at https://github.com/tengchn/Mugen-UMAP
Wind tunnel study of iron ore dust emissions from stockpile and train wagons
Authors: Fontana Arthur dos Reis Lemos , Silva Artur José Cunha da , Pontes Luana Silva , Mesquita André Luiz Amarante , Martins Marcio Ferreira , Junior Ronaldo Menezes dos Santos 
Published: July 2024

Abstract

This work presents the development of a research facility to evaluate dust emissions involving wagon and stockpile models, considering operational and environmental variables. Furthermore, the influence of wagon vibration along the railway was considered to match the experimental conditions more closely to reality. The experimental apparatus consisted of a wind tunnel to simulate the wind speed, two lamps with controlled power sources to simulate insolation, a spray nozzle to simulate rain, a turntable to modify the wind direction, a dynamic weighing system, and a particle counter to record particulate emissions during the test. Performance tests of solidifying-type dust suppressants were also conducted. A suppressant application system was incorporated into the wagon and stockpile models. The tests demonstrated that the experimental apparatus could evaluate the performance of dust suppressants and could be used for approval purposes. Tests with vibration revealed interesting effects resulting from material compaction in wagons. Endurance tests demonstrated the apparatus capacity in tests of this nature. Thus, the developed experimental apparatus could be employed as an important tool to develop scientific studies on dust emissions.
Rapid remote volcanic ashfall impact assessment for the 2022 eruption of Hunga volcano, Tonga: a bespoke approach and lessons identified
Authors: Weir Alana M. , Williams James H. , Wilson Thomas M. , Hayes Josh , Stewart Carol , Leonard Graham , Magill Christina , Jenkins Susanna , Williams Shaun , Craig Heather M. , Kula Taaniela , Fraser Stuart , Pomonis Antonios , Gunasekera Rashmin , Daniell James E. , Coultas Emma 
Published: July 2024

Abstract

When disasters occur, rapid impact assessments are required to direct response priorities, support in-country efforts and inform the mobilisation of aid. The 15 January 2022 eruption of Hunga volcano, Tonga, and the resulting atmospheric shockwave, ashfall, underwater mass disturbance and tsunami, caused substantial impacts across the Kingdom of Tonga. Volcanic impacts of the scale observed after the eruption are rare, necessitating a reliance on international advice and assistance. The situation was complicated by the loss of Tonga’s international submarine fibreoptic cable, causing a complete loss of communications for approximately 20 days, along with border closures due to the COVID-19 pandemic. A need emerged for a rapid remote volcanic impact assessment and provision of specialist advice to help inform the response of international partners. Here we present a novel methodology for conducting rapid remote volcanic ashfall impact assessments, conducted over a 10-day period following the eruption. We used three different hazard models for ashfall thickness across the main island of Tongatapu and available asset information and vulnerability functions for buildings, agriculture, electricity networks, water supply and roads, to provide initial estimates of losses due to ashfall from the 15 January eruption. For buildings, we estimated losses, both as total losses and as percentages of the total replacement cost of buildings on Tongatapu. For agriculture, we made probabilistic estimates of production losses for three different crop classes. For ashfall cleanup, we estimated ranges of ashfall volumes requiring cleanup from road surfaces and roofs. For water supply, electricity networks and roads, our analysis was limited to assessing the exposure of important assets to ashfall, as we had insufficient information on system configurations to take the analysis further. Key constraints to our analysis were the limited nature of critical infrastructure asset inventories, and the lack of volcanic vulnerability models for tropical regions including Pacific Island nations. Key steps towards iteratively improving rapid remote impacts assessments will include developing vulnerability functions for tropical environments, including Pacific islands, as well as ground-truthing estimated losses from remote approaches against in-person impact assessment campaigns.