bluuebunny/crossref_metadata_2025_split huggingface dataset:
“It Could Have Been Us”: media frames and the coverage of Ukrainian, Afghan and Syrian refugee crises
Authors: Ajana Btihaj , Connell Hannah , Liddle Tyler 
Published: July 2024

AbstractRussia’s invasion of Ukraine in February 2022 forced millions of Ukrainians to flee their homes and seek refuge in other countries, resulting in one of Europe’s largest refugee crises in decades. Many countries were quick to mobilise and provide the needed assistance to Ukrainians refugees. In contrast to the usual responses to asylum seekers coming from outside Europe, EU countries as well as the UK were uncharacteristically welcoming. Similarly, news reports of the Ukraine refugee situation have been marked by affectionate headlines and an outpouring of support and sympathy arguably not seen previously in the context of other refugee crises outside of Europe. This prompted questions and discussions about the alleged double standards and disparities in the treatments and portrayals of refugees from different countries. Inspired by such discussions and through a media frame analysis approach, this article examines a sample of relevant online UK news articles from the BBC and The Sun and compares their coverage of the Ukrainian refugee crisis to that of the Syrian and Afghan ones. The overarching aim is to identify how these distinct refugee crises are framed within the sampled articles and whether there are, in fact, discursive differences in the representation and framing of these crises, as often claimed in existing debates on the subject.
Urban cultural dynamics in planning: a bibliometric analysis
Authors: Kattimani Raghavendra , Devadas Varuvel 
Published: July 2024

AbstractThis paper comprehends the global research scenario about incorporating cultural components in contemporary urban planning practice. Various urban cultural elements have been analysed under the umbrella of ‘Urban Cultural Dynamics’ (UCD). This study aims to identify hot spots and explore influential sources through a bibliometric investigation of the evolutionary patterns of cultural dynamics in urban planning research. Data was collected from the Web of Science core collection (1965-2021). The data mining tools VOSviewer, Biblioshiny, KNIME, and WordStat were used to analyse hot topics, keywords, influential journals, core papers, top authors, and cooperation networks of countries and institutions. The Analytical Hierarchy Process (AHP) is employed in journal analysis. The analysis showed that publications on UCD increased exponentially between 2016 and 2022. Italy (32), China (26), and Spain (18) are the top countries in total publications. Technical universities of Dresden and Munich have the most significant influence on UCD's research, with 103 and 101 total citations, respectively. Landscape and Urban Planning, Journal of Cultural Heritage, and Tourism Geographies are the top three consistently influential journals. The top ten core papers were identified. The keywords and topic analysis charted out the evolution of multidisciplinary UCD research topics. The hotspot analysis revealed the significance of cultural dynamics in sustainable urban development. The results highlighted the need for intercontinental cooperation between developed countries and the third world. The future scope of research on UCD topics is discussed in the conclusion.
Breastfeeding support among healthcare workers in Nigeria
Authors: Alao Michael Abel , Ibrahim Olayinka Rasheed , Briggs Datonye Christopher , Yekinni Sakiru Abiodun , Nri-Ezedi Chisom Adaobi , Sotimehin Sikirat Adetoun , Olasinde Yetunde Toyin , Aliu Rasaki , Borokinni Ayodeji Mathew , Elo-Ilo Jacinta Chinyere , Bello Oyeronke Olubunmi , Diala Udochukwu Michael , Olaniyi-George Joyce Foluke , Adeniyi Temilade Oluwatoyosi , Ashiru Usman Hadiza , Tongo Olukemi Oluwatoyin 
Published: July 2024

Abstract
Background
The exclusive breastfeeding rate in Sub-Saharan Africa is abysmally low, and based on current trends, achieving the World Health Organization's (WHO) global nutrition goal of a 50% exclusive breastfeeding rate by 2025 will require an additional three decades.

Methods
This is a cross-sectional study involving healthcare workers (HCWs) providing direct care to breastfeeding mothers in six geopolitical zones in Nigeria. HCWs were recruited using a stratified random sampling method, with a minimum sample size of 1537. Data was collected through validated-interviewer-administered-questionnaires.

Results
The mean age of the 1294 respondents was 35.2 ± 10.0 years, with a male-to-female ratio of 1:3. Overall, breastfeeding knowledge was subsufficient (41.2% across three domains), with specific knowledge gaps observed in breastfeeding for mothers with breast cancer (13.4%) and hepatitis B (59.4%). Only 18.9% correctly identified laid-back and cross-cradle breastfeeding positions. High school and tertiary education were significantly associated with sufficient breastfeeding knowledge (AOR: 2.2, 95% CI 1.299–3.738; AOR: 2.0, 95% CI 1.234–3.205). Negative attitudes toward breastfeeding support were associated with being female (AOR: 1.5, 95% CI 1.094–1.957), while being a doctor was linked to the lowest instructional support (AOR: 0.3, 95% CI 0.118–0.661). Positive attitudes toward breastfeeding support were significantly associated with sufficient knowledge (AOR: 2.4, 95% CI 1.833–3.161; p < 0.001), but not with technical knowledge (AOR: 0.8, 95% CI 0.629–0.993).

Conclusion
Healthcare workers showed subsufficient overall breastfeeding knowledge, especially regarding breastfeeding in maternal illnesses and positioning. Targeted programs are needed to improve breastfeeding support knowledge, instructional support and attitudes, especially among female HCWs and physicians.
Mobile toolbox (MTB) remote measures of executive function and processing speed: development and validation
Authors: Novack Miriam A. , Young Stephanie Ruth , Dworak Elizabeth M. , Kaat Aaron J. , Slotkin Jerry , Nowinski Cindy , Yao Lihua , Adam Hubert , Stoeger Jordan , Hosseinian Zahra , Amagai Saki , Pila Sarah , Varela Diaz Maria , Almonte Correa Anyelo , Alperin Keith , Carlson Sonia , Kellen Michael , Omberg Larsson , Camacho Monica R. , Landavazo Bernard , Nosheny Rachel L. , Weiner Michael W. , Gershon Richard C. 
Published: July 2024

AbstractObjective:The ability to remotely monitor cognitive skills is increasing with the ubiquity of smartphones. The Mobile Toolbox (MTB) is a new measurement system that includes measures assessing Executive Functioning (EF) and Processing Speed (PS): Arrow Matching, Shape-Color Sorting, and Number-Symbol Match. The purpose of this study was to assess their psychometric properties.Method:MTB measures were developed for smartphone administration based on constructs measured in the NIH Toolbox® (NIHTB). Psychometric properties of the resulting measures were evaluated in three studies with participants ages 18 to 90. In Study 1 (N = 92), participants completed MTB measures in the lab and were administered both equivalent NIH TB measures and other external measures of similar cognitive constructs. In Study 2 (N = 1,021), participants completed the equivalent NIHTB measures in the lab and then took the MTB measures on their own, remotely. In Study 3 (N = 168), participants completed MTB measures twice remotely, two weeks apart.Results:All three measures exhibited very high internal consistency and strong test-retest reliability, as well as moderately high correlations with comparable NIHTB tests and moderate correlations with external measures of similar constructs. Phone operating system (iOS vs. Android) had a significant impact on performance for Arrow Matching and Shape-Color Sorting, but no impact on either validity or reliability.Conclusions:Results support the reliability and convergent validity of MTB EF and PS measures for use across the adult lifespan in remote, self-administered designs.
Quantifying Biogeochemical Controls of Open Ocean CDOM From a Global Mechanistic Model
Authors: Yamamoto Kana , DeVries Tim , Siegel David A. , Nelson Norman B. 
Published: July 2024

AbstractChromophoric dissolved organic matter (CDOM) is an important part of ocean carbon biogeochemistry with relevance to long‐term observations of ocean biology due to its dominant light absorption properties. Thus, understanding the underlying processes controlling CDOM distribution is important for predicting changes in light availability, primary production, and the cycling of biogeochemically important matter. We present a biogeochemical CDOM model for the open ocean with two classes of biological lability and uncertainty estimates derived from 43 ensemble members that provide a range of model parameter variations. Ensemble members were optimized to match global ocean in situ CDOM measurements and independently assessed against satellite CDOM estimates, which showed good agreement in spatial patterns. Based on the ensemble median, we estimate that about 7% of open‐ocean CDOM is of terrestrial origin, but the ensemble range is large (<0.1–26%). CDOM is rapidly removed in the surface ocean (<200 m) due to biological degradation for short‐lived CDOM and photodegradation for long‐lived CDOM, leading to a net flux of CDOM to the surface ocean from the dark ocean. This deep‐water source (ensemble median 0.001 m−1 yr−1) is similar in magnitude to the riverine flux (0.005 m−1 yr−1) into the surface ocean. Though discrepancies between the model and observational data remain, this work serves as a foundational framework for a mechanistic assessment of global CDOM distribution that is independent of satellite data.
Sea Ice Interannual Variability and Sensitivity to Fall Oceanic Conditions and Winter Air Temperature in the Gulf of St. Lawrence, Canada
Authors: Galbraith Peter S. , Sévigny Caroline , Bourgault Daniel , Dumont Dany 
Published: July 2024

AbstractThe Gulf of St. Lawrence has been nearly free of sea ice in the winter six times in its recorded history, four of which have occurred since 2010. This study examines the inter‐annual variability of sea ice cover characteristics (1969–2024) and winter mixed layer heat content (1996–2024), their sensitivity to fall oceanic conditions (since fall of 1995) and to winter air temperatures. The study finds no relationship between fall oceanic conditions with either the first occurrence of sea ice, maximum seasonal estimated volume or winter mixed layer heat content. However, it shows that the first occurrence of sea ice in the northwestern Gulf is related to the timing of sea surface temperature crossing the 1°C threshold with a lag time of 30–37 days, and with air temperature dropping below −2°C with a lag of 37–44 days; longer lags have weak correlations. The seasonal maximum conditions in area or estimated volume can be estimated by the preceding measurements of the same metrics with a lead time of only 29 days for volume and 36 days for area. The average air temperature over the Gulf between December and February or March is highly correlated to seasonal maximum sea ice area and estimated volume, as well as ice season duration. The six nearly ice‐free winters correspond to the warmest December to February (or December to March) average air temperatures over the Gulf. A warming of >1.9°C–2.4°C (DJFM) or >2.2°C–2.9°C (DJF) above the 1991–2020 climatology leads to nearly ice‐free conditions.
Fine Crust‐Mantle Structure of the Major Tectonic Boundaries Between the North China Craton and Central Asian Orogenic Belt Revealed From Rayleigh Wave Phase Velocities and Receiver Functions
Authors: Yang Tingwei , Xu Tao , Ai Yinshuang , Yang Jinhui , Yuan Huaiyu 
Published: July 2024

AbstractThe Tanlu Fault Zone (TLFZ) and Chifeng‐Kaiyuan Fault (CKF) serve as tectonic boundaries between the North China Craton (NCC) and the Central Asian Orogenic Belt (CAOB). Clarifying the refined structure of these tectonic boundaries is crucial for understanding the relationships between the tectonic units and the heterogeneity in the destruction of the NCC. In this study, two linear seismic arrays were deployed across these tectonic boundaries. Based on the phase velocity dispersion and receiver functions extracted from the seismic arrays, the Hamiltonian Monte Carlo algorithm was employed for the joint inversion of the S‐wave velocity (Vs) in the crust and uppermost mantle. The Vs model was then used to correct the time differences in common conversion point (CCP) stacking. The CCP stacking results indicate that the boundary faults TLFZ and CKF are both whole‐crustal faults that separate the NCC and CAOB. The Vs structure showed a significant low‐velocity anomaly in the mantle beneath the NCC, with intense seismic activity within the crust. This suggests that the NCC was affected by the subduction of the Western Pacific, leading to crustal and mantle destruction. In contrast, the CAOB exhibited a clear high‐velocity anomaly with relatively stable crustal structures. We believe that the NCC and CAOB have undergone structural modification and destruction due to the closure of the Paleo‐Asian Ocean and the activities of the TLFZ since the Late Mesozoic. During the Cenozoic, the region east of the TLFZ experienced more significant destruction in the NCC than the other adjacent tectonic units.
Permafrost and Active Layer Temperature and Freeze/Thaw Timing Reflect Climatic Trends at Bayelva, Svalbard
Authors: Grünberg Inge , Groenke Brian , Westermann Sebastian , Boike Julia 
Published: July 2024

AbstractPermafrost warming has been observed all around the Arctic, however, variations in temperature trends and their drivers remain poorly understood. We present a comprehensive analysis of climatic changes spanning 25 years (1998–2023) at Bayelva (78.92094°N, 11.83333°E) on Spitzbergen, Svalbard. The quality controlled hourly data set includes air temperature, radiation fluxes, snow depth, rainfall, active layer temperature and moisture, and, since 2009, permafrost temperature. Our Bayesian trend analysis reveals an annual air temperature increase of 0.9 ± 0.5°C/decade and strongest warming in September and October. We observed a significant shortening of the snow cover by −14 ± 8 days/decade, coupled with reduced winter snow depth. The active layer simultaneously warmed by 0.6 ± 0.7°C/decade at the top and 0.8 ± 0.5°C/decade at the bottom. While the soil surface got drier, in particular during summer, soil moisture below increased in accordance with the longer unfrozen period and higher winter temperatures. The thawed period prolonged by 10–15 days/decade at different depths. In contrast to earlier top‐soil warming, we observed stable temperatures since 2010 and only little permafrost warming (0.14 ± 0.13°C/decade). This is likely due to recently stable winter air temperature and continuously decreasing winter snow depth. This recent development highlights a complex interplay among climate and soil variables. Our distinctive long‐term data set underscores (a) the changes in seasonal warming patterns, (b) the influential role of snow cover decline, and (c) that air temperature alone is not a sufficient indicator of change in permafrost environments, thereby highlighting the importance of investigating a wider range of parameters, such as soil moisture and snow characteristics.
Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors
Authors: Krishnacoumar Brenda , Stenzel Martin , Garibagaoglu Hilal , Omata Yasunori , Sworn Rachel L. , Hofmann Thea , Ipseiz Natacha , Czubala Magdalena A. , Steffen Ulrike , Maccataio Antonio , Stoll Cornelia , Böhm Christina , Herrmann Martin , Uderhardt Stefan , Jenkins Robert H. , Taylor Philip R. , Grüneboom Anika , Zaiss Mario M. , Schett Georg , Krönke Gerhard , Scholtysek Carina 
Published: July 2024

AbstractEfficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing osteoclasts. However, the exact molecular factors and mechanisms controlling osteoclast fusion remain incompletely understood. Here we identify RANKL-mediated activation of caspase-8 as early key event during osteoclast fusion. Single cell RNA sequencing-based analyses suggested that activation of parts of the apoptotic machinery accompanied the differentiation of osteoclast precursors into mature multinucleated osteoclasts. A subsequent characterization of osteoclast precursors confirmed that RANKL-mediated activation of caspase-8 promoted the non-apoptotic cleavage and activation of downstream effector caspases that translocated to the plasma membrane where they triggered activation of the phospholipid scramblase Xkr8. Xkr8-mediated exposure of phosphatidylserine, in turn, aided cellular fusion of osteoclast precursors and thereby allowed generation of functional multinucleated osteoclast syncytia and initiation of bone resorption. Pharmacological blockage or genetic deletion of caspase-8 accordingly interfered with fusion of osteoclasts and bone resorption resulting in increased bone mass in mice carrying a conditional deletion of caspase-8 in mononuclear osteoclast precursors. These data identify a novel pathway controlling osteoclast biology and bone turnover with the potential to serve as target for therapeutic intervention during diseases characterized by pathologic osteoclast-mediated bone loss.
Advancing stroke recovery: unlocking the potential of cellular dynamics in stroke recovery
Authors: Sahebi Keivan , Foroozand Hassan , Amirsoleymani Mobina , Eslamzadeh Saghi , Negahdaripour Manica , Tajbakhsh Amir , Rahimi Jaberi Abbas , Savardashtaki Amir 
Published: July 2024

AbstractStroke stands as a predominant cause of mortality and morbidity worldwide, and there is a pressing need for effective therapies to improve outcomes and enhance the quality of life for stroke survivors. In this line, effective efferocytosis, the clearance of apoptotic cells, plays a crucial role in neuroprotection and immunoregulation. This process involves specialized phagocytes known as “professional phagocytes” and consists of four steps: “Find-Me,” “Eat-Me,” engulfment/digestion, and anti-inflammatory responses. Impaired efferocytosis can lead to secondary necrosis and inflammation, resulting in adverse outcomes following brain pathologies. Enhancing efferocytosis presents a potential avenue for improving post-stroke recovery. Several therapeutic targets have been identified, including osteopontin, cysteinyl leukotriene 2 receptor, the µ opioid receptor antagonist β-funaltrexamine, and PPARγ and RXR agonists. Ferroptosis, defined as iron-dependent cell death, is now emerging as a novel target to attenuate post-stroke tissue damage and neuronal loss. Additionally, several biomarkers, most importantly CD163, may serve as potential biomarkers and therapeutic targets for acute ischemic stroke, aiding in stroke diagnosis and prognosis. Non-pharmacological approaches involve physical rehabilitation, hypoxia, and hypothermia. Mitochondrial dysfunction is now recognized as a major contributor to the poor outcomes of brain stroke, and medications targeting mitochondria may exhibit beneficial effects. These strategies aim to polarize efferocytes toward an anti-inflammatory phenotype, limit the ingestion of distressed but viable neurons, and stimulate efferocytosis in the late phase of stroke to enhance post-stroke recovery. These findings highlight promising directions for future research and development of effective stroke recovery therapies.
Synthetic macrolides overcoming MLSBK-resistant pathogens
Authors: Ma Cong-Xuan , Li Ye , Liu Wen-Tian , Li Yun , Zhao Fei , Lian Xiao-Tian , Ding Jing , Liu Si-Meng , Liu Xie-Peng , Fan Bing-Zhi , Liu Li-Yong , Xue Feng , Li Jian , Zhang Jue-Ru , Xue Zhao , Pei Xiao-Tong , Lin Jin-Zhong , Liang Jian-Hua 
Published: July 2024

AbstractConventional macrolide-lincosamide-streptogramin B-ketolide (MLSBK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base A2058 or its G2058 mutation, while the presence of unmodified A2058 is crucial for high selectivity of traditional MLSBK in targeting pathogens over human cells. The absence of effective modes of action reinforces the prevailing belief that constitutively antibiotic-resistant Staphylococcus aureus remains impervious to existing macrolides including telithromycin. Here, we report the design and synthesis of a novel series of macrolides, featuring the strategic fusion of ketolide and quinolone moieties. Our effort led to the discovery of two potent compounds, MCX-219 and MCX-190, demonstrating enhanced antibacterial efficacy against a broad spectrum of formidable pathogens, including A2058-methylated Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, and notably, the clinical Mycoplasma pneumoniae isolates harboring A2058G mutations which are implicated in the recent pneumonia outbreak in China. Mechanistic studies reveal that the modified quinolone moiety of MCX-190 establishes a distinctive secondary binding site within the nascent peptide exit tunnel. Structure-activity relationship analysis underscores the importance of this secondary binding, maintained by a sandwich-like π–π stacking interaction and a water–magnesium bridge, for effective engagement with A2058-methylated ribosomes rather than topoisomerases targeted by quinolone antibiotics. Our findings not only highlight MCX-219 and MCX-190 as promising candidates for next-generation MLSBK antibiotics to combat antibiotic resistance, but also pave the way for the future rational design of the class of MLSBK antibiotics, offering a strategic framework to overcome the challenges posed by escalating antibiotic resistance.
Underwater light source changes nitrogen and phosphorus removal pathways by Vallisneria spinulosa Yan growth system
Authors: Zhao Jinshan , Zhou Xiaolin , Fan Chunzhen , Wang Zhiquan , Jin Zhan , Bei Ke , Zheng Xiangyong , Zhao Min , Wu Suqing 
Published: July 2024

AbstractVallisneria spinulosa Yan (V.spinulosa Yan) with good ability of water purification is often used for ecological restoration of polluted water bodies. However, it is difficult to survive in turbid water bodies due to the low lighting condition. This study explored the feasibility of introducing artificial underwater light source into water bodies with high turbidity to strengthen the water restoration by V.spinulosa Yan. Addition of underwater light source promoted the clonal reproduction ability of V.spinulosa Yan, thus enhancing the removal loads of total nitrogen (TN), total phosphorus (TP), and nitrate nitrogen ($${\mathrm{NO}}^{-}_{3}{\mbox{-}}{\mathrm{N}}$$

NO

3

−

-

N

) by 1.60–3.43 × 10−2, 1.49–3.49 × 10−3, and 0.80–2.06 × 10−2 g m−2 d−1, respectively. Underwater light source significantly reduced the abundance of microbial community on V.spinulosa Yan leaves, as well as most nitrifying bacteria (Nitrosomonadaceae) and denitrifying bacteria (Nitrospira, Comamonadaceae, and Rhodocyclaceae) in the system. But the attachment of some Cyanophyta (Chloroplast and Cyanobacteria) and Photosynthetic bacteria (Rhodobacter) onto the leaves and the growth of Methyloligellaceae in water and sediments were promoted. Nitrogen and phosphorus removal by the growth system of V.spinulosa Yan without underwater light source mainly depended on the biological processes by functional bacteria, while the absorption and co-assimilation effect of V.spinulosa Yan with underwater light source.