bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Lipid-Structured Model of Atherosclerosis with Macrophage Proliferation
Authors: Chambers Keith L. , Watson Michael G. , Myerscough Mary R. 
Published: July 2024

AbstractAtherosclerotic plaques are fatty deposits that form in the walls of major arteries and are one of the major causes of heart attacks and strokes. Macrophages are the main immune cells in plaques and macrophage dynamics influence whether plaques grow or regress. Macrophage proliferation is a key process in atherosclerosis, particularly in the development of mid-stage plaques, but very few mathematical models include proliferation. In this paper we reframe the lipid-structured model of Ford et al. (J Theor Biol 479:48–63, 2019. https://doi.org/10.1016/j.jtbi.2019.07.003) to account for macrophage proliferation. Proliferation is modelled as a non-local decrease in the lipid structural variable. Steady state analysis indicates that proliferation assists in reducing eventual necrotic core lipid content and spreads the lipid load of the macrophage population amongst the cells. The contribution of plaque macrophages from proliferation relative to recruitment from the bloodstream is also examined. The model suggests that a more proliferative plaque differs from an equivalent (defined as having the same lipid content and cell numbers) recruitment-dominant plaque in the way lipid is distributed amongst the macrophages. The macrophage lipid distribution of an equivalent proliferation-dominant plaque is less skewed and exhibits a local maximum near the endogenous lipid content.
Forschungsethische Prinzipien und methodische Güte in der Umfrageforschung
Authors: Zillich Arne Freya , Schlütz Daniela , Roehse Eva-Maria , Möhring Wiebke , Link Elena 
Published: July 2024

ZusammenfassungDie standardisierte Befragung ist eine zentrale empirische Erhebungsmethode in der Kommunikations- und Medienwissenschaft. Es existieren zahlreiche theoretische Zugänge und empirische Studien, um die methodischen Prinzipien und Standards von Umfragen besser zu verstehen und in ihrer Wirkung zu optimieren. Für die Durchführung empirischer Studien sind Kriterien der methodischen Güte zentrale Entscheidungskriterien. Für die Sicherung wissenschaftlicher Qualität ist eine ausschließliche Beachtung methodischer Aspekte jedoch nicht ausreichend; auch aus den forschungsethischen Prinzipien Selbstbestimmung, Schadensvermeidung und Gerechtigkeit sind Beurteilungskriterien ableitbar. Allerdings können methodische und ethische Anforderungen auch im Widerspruch zueinanderstehen; entsprechende Dilemmata können in jeder Phase des Forschungsprozesses auftreten. In solchen Fällen ist eine systematische Güterabwägung zwischen ethischen Bedenken und methodischen Erfordernissen nötig. In der vorliegenden Studie wurden im Rahmen des BMBF-geförderten FeKoM-Verbundprojekts 29 empirisch arbeitende Kommunikationswissenschaftler*innen aus dem deutschsprachigen Raum interviewt, um zu ermitteln, wie sie diese Herausforderungen wahrnehmen und wie sie mit ihnen im Forschungsalltag umgehen. Die Ergebnisse zeigen, dass die Interviewten keinen der beiden Aspekte priorisieren, sondern danach streben, methodische und ethische Anforderungen miteinander in Einklang zu bringen. Gleichzeitig werden Herausforderungen im jeweiligen Einzelfall sowie grundsätzliche Bedenken hinsichtlich des Stellenwertes von Forschungsethik deutlich.
Dynamic capabilities as a moderator: enhancing the international performance of SMEs with international entrepreneurial orientation
Authors: Fernandes Cristina I. , Ferreira João J. M. , Veiga Pedro Mota , Hu Qilin , Hughes Mathew 
Published: July 2024

AbstractThis paper explores the impact of International Entrepreneurial Orientation (IEO) on the international performance of Small and Medium-sized Enterprises (SMEs), with a focus on the post-COVID-19 era. IEO, treated as a subdimension of entrepreneurial orientation, is crucial for SMEs in global markets, especially given the challenges posed by the pandemic. The study examines dynamic capabilities as a moderating factor in the IEO-international performance relationship, based on the resource-based view (RBV). A survey involving 120 internationalized SMEs from industrial and service sectors was conducted, and data were analyzed using Structural Equation Modeling (SEM) through Partial Least Squares (PLS). The findings indicate that seizing and reconfiguring capabilities significantly enhance the IEO-international performance link while sensing capabilities do not show a notable impact. This research contributes to the literature by affirming the role of dynamic capabilities in strengthening SMEs’ international performance through IEO, highlighting the differential impact of various dynamic capabilities, and offering insights into the specific roles of these capabilities as moderators in the IEO-international performance relationship. The study underscores the importance of strategic entrepreneurial orientation and dynamic capabilities for SMEs in the global market.
Telemedicine in Endourology for Patient Management and Healthcare Delivery: Current Status and Future Perspectives
Authors: Talyshinskii Ali , Naik Nithesh , Hameed B. M. Zeeshan , Khairley Gafour , Randhawa Princy , Somani Bhaskar Kumar 
Published: July 2024

Abstract
Purpose of Review
Researchers have examined how telemedicine affects endourological patients. This review analyzes the literature to determine telemedicine's benefits and limitations in endourology.

Recent Findings
Many studies were devoted to describing the effect of telemedicine on endourological patient satisfaction, optimization of the clinical decision-making among patients with kidney and ureteric stones, the effectiveness of telemedicine in the management of patients with indications for PCNL, follow-up for patients with urolithiasis and describing financial effectiveness for the patients after BOO surgery. The authors describe phone calls, video calls, and online booking platforms as used as telemedicine technology. However, several concerns also exist, such as the necessity of internet connections and appropriate devices, different receptivity among certain subgroups, data safety, and different regulatory environments among countries.

Summary
Telemedicine offers the potential to reduce patient travel time, expedite decision-making, and save costs in endourology. However, its everyday implementation is challenging due to various obstacles faced by patients and providers, hindering the realization of its full potential and necessitating a systematic approach to problem-solving.
Longitudinal Assessment of Blood-Based Inflammatory, Neuromuscular, and Neurovascular Biomarker Profiles in Intensive Care Unit–Acquired Weakness: A Prospective Single-Center Cohort Study
Authors: Klawitter Felix , Laukien Friederike , Fischer Dagmar-C. , Rahn Anja , Porath Katrin , Danckert Lena , Bajorat Rika , Walter Uwe , Patejdl Robert , Ehler Johannes 
Published: July 2024

Abstract

Background
The diagnosis of intensive care unit (ICU)-acquired weakness (ICUAW) and critical illness neuromyopathy (CINM) is frequently hampered in the clinical routine. We evaluated a novel panel of blood-based inflammatory, neuromuscular, and neurovascular biomarkers as an alternative diagnostic approach for ICUAW and CINM.

Methods
Patients admitted to the ICU with a Sequential Organ Failure Assessment score of ≥ 8 on 3 consecutive days within the first 5 days as well as healthy controls were enrolled. The Medical Research Council Sum Score (MRCSS) was calculated, and motor and sensory electroneurography (ENG) for assessment of peripheral nerve function were performed at days 3 and 10. ICUAW was defined by an MRCSS < 48 and CINM by pathological ENG alterations, both at day 10. Blood samples were taken at days 3, 10, and 17 for quantitative analysis of 18 different biomarkers (white blood cell count, C-reactive protein, procalcitonin, C-terminal agrin filament, fatty-acid-binding protein 3, growth and differentiation factor 15, syndecan 1, troponin I, interferon-γ, tumor necrosis factor-α, interleukin-1α [IL-1α], IL-1β, IL-4, IL-6, IL-8, IL-10, IL-13, and monocyte chemoattractant protein 1). Results of the biomarker analysis were categorized according to the ICUAW and CINM status. Clinical outcome was assessed after 3 months.

Results
Between October 2016 and December 2018, 38 critically ill patients, grouped into ICUAW (18 with and 20 without) and CINM (18 with and 17 without), as well as ten healthy volunteers were included. Biomarkers were significantly elevated in critically ill patients compared to healthy controls and correlated with disease severity and 3-month outcome parameters. However, none of the biomarkers enabled discrimination of patients with and without neuromuscular impairment, irrespective of applied classification.

Conclusions
Blood-based biomarkers are generally elevated in ICU patients but do not identify patients with ICUAW or CINM.

Trial registration
: ClinicalTrials.gov identifier: NCT02706314.
Physiological biodistribution on Ga68-PSMA PET/CT and the factors effecting biodistribution
Authors: Arçay Öztürk Ayça , Erkılıç Metin , Bural Gonca Gül , Aydın Funda , Boz Adil 
Published: July 2024

Abstract
Aim
The study aims to determine the physiological and pathophysiological distribution of the radiopharmaceutical (Ga68-PSMA-617) and investigate whether there are differences in distribution according to the laboratory, histopathological and clinical findings that can affect image evaluation. Also, we aimed to determine cut-off values to distinguish physiological and pathological uptake in prostate, bone, and lymph nodes.

Materials and Methods
229 prostate cancer patients who underwent Ga68-PSMA PET/CT at our department were retrospectively analyzed. The patients were grouped according to PET/CT results, Gleason scores, PSA values, received treatments, metastatic status and other laboratory values. The SUV values of the organs, tissues, and pathological lesions of the patients in these subgroups were compared among themselves.

Results
No significant difference was detected in the physiological uptake of lymph nodes and bone between the groups. In the group with patients that received androgen deprivation therapy (ADT), the bone metastasis SUV values were found to be higher and the SUV values of the submandibular gland and renal cortex were found to be lower (Mann–Whitney U, p = 0.043; 0.004; 0.01, respectively). In the group with patients who received radiotherapy, the normal prostate tissue SUV values were determined to be higher (Mann–Whitney U, p = 0.009). The SUV values of the submandibular gland, muscle, liver, and blood pool were found to be lower in the group of patients with high serum LDH values. The cut-off SUVmax value was determined to be 6.945 (sensitivity 89.6%, specificity 98.1%) for primary prostate lesion; 4.72 for lymph node metastasis; 4.25 for bone metastasis. The serum PSA cut-off value to distinguish the negative/positive groups was found to be 1,505 (sensitivity 79.7%, specificity 77.3%).

Conclusion
In conclusion, PSMA-617 demonstrates a similar biodistribution with other PSMA ligands. The physiological uptake of lymph nodes and bone which are mostly metastasized in prostate cancer, are not affected by the factors we examined. It should be kept in mind that the normal prostate tissue uptake may increase in patients receiving radiotherapy, and the physiological/pathological uptake of the organs may differ due to the changes in PSMA expression in patients receiving ADT, tumor burden, and kidney function may affect the biodistribution.
Ewes of a leather flock together. Feeding management systems during Late Antiquity in the northeast of the Iberian Peninsula (4th c. – 8th c. AD): a dental microwear approach
Authors: Gallego-Valle Abel , Colominas Lídia , Palet Josep Maria 
Published: July 2024

AbstractIn recent years, the dental microwear analysis technique has been proven as an approach for contributing to animal husbandry research. It has been tested with good results on providing information related to the animal feeding strategies of bygone agri-livestock societies. In this paper, we present the first dental microwear study from the northeast of Tarraconensis province –the administrative region covering the northeastern Iberian Peninsula in Late Antiquity (4th – 8th c. CE) – in order to provide first order information about the different systems that may have been used to nourish sheep flocks. A total of 146 lower sheep (Ovis aries) molars from five archaeological sites were analysed. The results allow us to propose that different livestock practices were conducted, and various natural resources were exploited by the region’s inhabitants during Late Antiquity, with fodder being particularly important as a feeding system to nourish the flock.
Prevalence of intestinal protozoan parasites among Asian schoolchildren: a systematic review and meta-analysis
Authors: Abdoli Amir , Olfatifar Meysam , Eslahi Aida Vafae , Moghadamizad Zeinab , Nowak Oskar , Pirestani Majid , Karimipour-saryazdi Amir , Badri Milad , Karanis Panagiotis 
Published: July 2024

Abstract
Purpose
Intestinal protozoan parasites among Asian schoolchildren are a subject of concern due to their prevalence and potential health impact. Understanding and addressing this issue is crucial for public health in the region.

Methods
We conducted a comprehensive search for articles published up to December 2023 across four databases, including Scopus, PubMed, ProQuest, and Web of Science. To estimate the combined prevalence, a random-effects model with a 95% confidence interval (CI) was applied, and the statistical analysis was performed using meta-analysis packages in R version (3.6.1). This study is registered with PROSPERO (CRD42023481146).

Results
Among 131 eligible articles, the prevalence of intestinal protozoan parasites was 0.208 (95% CI = 0.180–0.238). Lebanon and Tajikistan had the highest country-level prevalence at 0.851 and 0.836, respectively, with Giardia duodenalis being the most prevalent species at 0.082.

Conclusion
In summary, our study highlights the urgent public health issue of protozoan parasites among Asian schoolchildren due to poor sanitation and water quality. Immediate interventions are essential, considering climate and socioeconomic factors, to combat these infections and improve overall health.
Merging TROPOMI and eddy covariance observations to quantify 5-years of daily CH4 emissions over coal-mine dominated region
Authors: Hu Wei , Qin Kai , Lu Fan , Li Ding , Cohen Jason B. 
Published: July 2024

AbstractA simple and flexible mass balance approach was applied to observations of XCH4 from TROPOMI to estimate CH4 emissions over Shanxi Province, including the impacts of advective transport, pressure transport, and atmospheric diffusion. High-frequency eddy-covariance flux observations were used to constrain the driving terms of the mass balance equation. This equation was then used to calculate day-to-day and 5 km × 5 km grided CH4 emissions from May 2018 to July 2022 based on TROPOMI RPRO column CH4 observations. The Shanxi-wide emissions of CH4, 126 ± 58.8 ug/m2/s, shows a fat tail distribution and high variability on a daily time scale (the 90th percentile is 2.14 times the mean and 2.74 times the median). As the number of days in the rolling average increases, the change in the variation decreases to 128 ± 35.7 ug/m2/s at 10-day, 128 ± 19.8 ug/m2/s at 30-day and 127 ± 13.9 ug/m2/s at 90-day. The range of values of the annual mean emissions on coal mine grids within Shanxi for the years 2018 to 2022 was 122 ± 58.2, 131 ± 71.2, 111 ± 63.6, 129 ± 87.1, and 138 ± 63.4 ug/m2/s, respectively. The 5-year average emissions from TROPOMI are 131 ± 68.0 ug/m2/s versus 125 ± 94.6 ug/m2/s on the grids where the EDGAR bottom-up database also has data, indicating that those pixels with mines dominate the overall emissions in terms of both magnitude and variability. The results show that high-frequency observation-based campaigns can produce a less biased result in terms of both the spatial and temporal distribution of CH4 emissions as compared with approaches using either low-frequency data or bottom-up databases, that coal mines dominate the sources of CH4 in Shanxi, and that the observed fat tail distribution can be accounted for using this approach.
Māori (Flexible) Learning Spaces, Old and New
Authors: Stewart Georgina Tuari , Benade Leon , Smith Valance , Wells Alastair , Yates Amanda 
Published: July 2024

AbstractMāori aspirations in education have not been served by past national policies. It is hard to extinguish the influence of monoculturalism, whereby schools were used to colonise Māori by enforcing linguistic and cultural assimilation. The history of debate on Innovative Learning Environments (ILE) and Flexible Learning Spaces (FLS) demonstrates the ongoing dominance of this Eurocentric, monocultural approach. Official New Zealand education policy and practice follows international trends in school design, moving away from traditional single-cell classrooms towards more open and inter-connected spaces, despite no real evidence concerning the relative effects on learning of each classroom type. Meanwhile, school marae have been around for several decades, but largely ignored in national ILE and FLS policy and research literature. Our experiences lead us to suggest that Māori identity must be ‘built in’ not ‘added on’ to monocultural ILE frameworks, and for this reason, spatiality is crucial in Māori teaching and learning spaces. This article explores the notion of ‘Māori learning spaces.’
An Intrusion Detection System on The Internet of Things Using Deep Learning and Multi-objective Enhanced Gorilla Troops Optimizer
Authors: Asgharzadeh Hossein , Ghaffari Ali , Masdari Mohammad , Gharehchopogh Farhad Soleimanian 
Published: July 2024

AbstractIn recent years, developed Intrusion Detection Systems (IDSs) perform a vital function in improving security and anomaly detection. The effectiveness of deep learning-based methods has been proven in extracting better features and more accurate classification than other methods. In this paper, a feature extraction with convolutional neural network on Internet of Things (IoT) called FECNNIoT is designed and implemented to better detect anomalies on the IoT. Also, a binary multi-objective enhance of the Gorilla troops optimizer called BMEGTO is developed for effective feature selection. Finally, the combination of FECNNIoT and BMEGTO and KNN algorithm-based classification technique has led to the presentation of a hybrid method called CNN-BMEGTO-KNN. In the next step, the proposed model is implemented on two benchmark data sets, NSL-KDD and TON-IoT and tested regarding the accuracy, precision, recall, and F1-score criteria. The proposed CNN-BMEGTO-KNN model has reached 99.99% and 99.86% accuracy on TON-IoT and NSL-KDD datasets, respectively. In addition, the proposed BMEGTO method can identify about 27% and 25% of the effective features of the NSL-KDD and TON-IoT datasets, respectively.
Sexual Function of Women with and without Pregnancy-Related Pelvic Girdle Pain and its Relationship with Physical Activity, Kinesiophobia and Body Image: A Cross-Sectional Comparative Study
Authors: Yenişehir Semiha , Karakaya İlkim Çıtak , Özbey Gürkan 
Published: July 2024

AbstractThe aim of this study was to compare the sexual function of women with and without pregnancy-related PGP, and to investigate its relationship with physical activity (PA), kinesiophobia, and body image (BI). Demographic characteristics, sexual function (Pregnancy Sexual Response Inventory), PA (Pregnancy Physical Activity Questionnaire), kinesiophobia (Tampa Kinesiophobia Scale), and BI (Body Image in Pregnancy Scale) of 125 pregnant women were recorded. In the PGP group (n = 46), visual analogue scales were used to assess the pain intensity during resting and sexual activity, and Pelvic Girdle Questionnaire was used to evaluate the activity limitation. Although total sexual function and BI scores of the groups were similar (p > 0.05), dyspareunia during pregnancy and level of kinesiophobia were higher, and energy expenditure during moderate-intensity PA was lower in pregnant women with PGP (p < 0.05). The PGP group had moderate activity limitation and reported increased PGP intensity during sexual activities (p < 0.001). PA level was significantly correlated with sexual desire (r = 0.180), and overall sexual function was correlated with kinesiophobia (r = -0.344) and BI (r = -0.199) during pregnancy (p < 0.05). These findings suggest that pregnant women with PGP are more vulnerable to sexual dysfunctions, and there is a need to develop biopsychosocial framework-oriented management strategies which aim to improve PA level and to eliminate psychological factors such as kinesiophobia and negative BI.Clinical Trial Registration: NCT05990361
Neurocysticercosis Prevalence and Characteristics in Communities of Sinda District in Zambia: A Cross-Sectional Study
Authors: Zulu Gideon , Stelzle Dominik , Gabriël Sarah , Trevisan Chiara , Van Damme Inge , Mubanga Chishimba , Schmidt Veronika , Ngowi Bernard J. , Welte Tamara M. , Magnussen Pascal , Ruether Charlotte , Fleury Agnes , Dorny Pierre , Bottieau Emmanuel , Phiri Isaac K. , Mwape Kabemba E. , Winkler Andrea S. ,   the SOLID consortium
Published: July 2024

Abstract
Background
This study aimed at describing the epidemiology of (neuro)cysticercosis as well as its clinical and radiological characteristics in a Taenia solium endemic district of Zambia.

Methods
This was part of a cross-sectional community-based study conducted in Sinda district to evaluate an antibody-detecting T. solium point-of-care (TS POC) test for taeniosis and (neuro)cysticercosis. All TS POC cysticercosis positive (CC+) participants and a subset of the TS POC cysticercosis negative (CC-) received a clinical evaluation and cerebral computed tomography (CT) examination for neurocysticercosis (NCC) diagnosis and staging.

Results
Of the 1249 participants with a valid TS POC test result, 177 (14%) were TS POC CC+ . Cysticercosis sero-prevalence was estimated to be 20.1% (95% confidence intervals [CI] 14.6–27.0%). In total, 233 participants received a CT examination (151 TS POC CC+ , 82 TS POC CC-). Typical NCC lesions were present in 35/151 (23%) TS POC CC+ , and in 10/82 (12%) TS POC CC- participants. NCC prevalence was 13.5% (95% CI 8.4–21.1%) in the study population and 38.0% (95% CI 5.2–87.4%) among people reporting epileptic seizures. Participants with NCC were more likely to experience epileptic seizures (OR = 3.98, 95% CI 1.34–11.78, p = 0.01) than those without NCC, although only 7/45 (16%) people with NCC ever experienced epileptic seizures. The number of lesions did not differ by TS POC CC status (median: 3 [IQR 1–6] versus 2.5 [IQR 1–5.3], p = 0.64). Eight (23%) of the 35 TS POC CC+ participants with NCC had active stage lesions; in contrast none of the TS POC CC- participants was diagnosed with active NCC.

Conclusion
NCC is common in communities in the Eastern province of Zambia, but a large proportion of people remain asymptomatic.