bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation Analysis of Potential Factors Influencing Graft Maturity After Anterior Cruciate Ligament Reconstruction
Authors: Li Hong , Chen Shuang , Tao Hongyue , Li Hongyun , Chen Shiyi 
Published: October 2014

Background: Postoperatively, signal changes of the reconstructed anterior cruciate ligament (ACL) graft on magnetic resonance imaging (MRI) images commonly occurs, which may be a cause for concern. The signal intensity changes are usually expressed by signal/noise quotient (SNQ) value, representing graft maturity. To date, little is known about the factors influencing the SNQ value of the reconstructed ACL graft. Purpose: To evaluate ACL graft SNQ value and associated factors after ACL reconstruction. Study Design: Case series; Level of evidence, 4. Methods: Male patients who underwent ACL reconstruction using autograft or allograft tendon from September 2004 to September 2011 were randomly invited to take part in this investigation, including functional scores, physical examination, and MRI scan. The femoral side graft was fixed with Endobutton CL or Rigidfix pins, and the tibial side graft was fixed with a bio-intrafix. SNQ values of each graft were measured on MRI to represent graft maturity. Sagittal ACL angle, ACL–Blumensaat line angle, and medial and lateral posterior tibial slope (PTS) were measured using MRI 3-dimensional dual-echo steady-state images. Potential risk factors, including age, body mass index, postoperative time, Tegner activity scale (TAS), sagittal ACL angle, ACL–Blumensaat line angle, medial PTS, lateral PTS, and primary graft diameter, were tested for their association with the graft SNQ value by multivariate stepwise regression analysis. Results: A total of 104 male subjects (mean follow-up, 30.7 months) were examined, including 62 allograft and 42 autograft reconstructions. There was a significant association between graft SNQ and postoperative time ( r = −0.431, P < .001), TAS ( r = 0.295, P = .002), and ACL–Blumensaat line angle ( r = −0.304, P = .002). Univariate regression analysis showed that TAS (β = 6.15, P < .001) positively correlated, postoperative time (β = −0.26, P < .001) negatively correlated, and ACL–Blumensaat line angle (β = −0.40, P = .038) negatively correlated with graft SNQ. Multivariate stepwise regression analysis showed that TAS, postoperative time, ACL–Blumensaat line angle, and age were significant independent factors associated with graft SNQ. Conclusion: The graft SNQ value had a significant positive correlation with physical activity level and a significant negative correlation with postoperative time in this study. Males with a shorter postoperative time and a higher physical activity level had higher graft signal intensity postoperatively.
NRAS

G12V
oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia
Authors: Sachs Zohar , LaRue Rebecca S. , Nguyen Hanh T. , Sachs Karen , Noble Klara E. , Mohd Hassan Nurul Azyan , Diaz-Flores Ernesto , Rathe Susan K. , Sarver Aaron L. , Bendall Sean C. , Ha Ngoc A. , Diers Miechaleen D. , Nolan Garry P. , Shannon Kevin M. , Largaespada David A. 
Published: October 2014

Key Points
NRAS G12V maintains leukemia self-renewal in a genetically engineered murine model of AML. NRAS G12V differentially regulates transcription and signaling among leukemic subpopulations.
Posttraumatic stress disorder and its risk factors among adolescent survivors three years after an 8.0 magnitude earthquake in China
Authors: Tian Yali , Wong Thomas KS , Li Jiping , Jiang Xiaolian 
Published: October 2014

Abstract

Background
Serious and long-lasting psychiatric consequences can be found in children and adolescents following earthquake, including the development of posttraumatic stress disorder (PTSD). Although researchers have been focused on PTSD recently, its prevalence and risk factors after a huge natural disaster are still unclear because of limited sample size. The purpose of this study is to explore the prevalence of posttraumatic stress disorder (PTSD) in adolescent survivors three years after the Wenchuan earthquake, describe PTSD symptoms, and to find out risk factors of PTSD.

Methods
A total of 4,604 adolescents from three middle schools which located in earthquake-stricken areas were recruited in this study. Instruments included the demographic questionnaire, questionnaire about earthquake exposure, the Social Support Appraisal Scale (SSA), the Posttraumatic stress disorder Checklist-Civilian Version (PCL-C), and the structured clinical interview for DSM-IV Disorders (SCID).

Results
The prevalence rate of PTSD was 5.7% (frequency: n = 261), and the most commonly occurring symptoms of PTSD were distress at reminders (64.5%), difficulty concentration (59.1%), and being easily startled (58.6%). Loss of houses and property, being injured, deaths of family members, and witness of death are positive risk factors of PTSD, and physical exercise and social support are negative risk factors of PTSD.

Conclusions
Professional and effective interventions are needed to reduce the development of PTSD among adolescents after the Wenchuan earthquake, especially for these who lost their houses or property and lost their family members, witnessed death, and lacked of social support in the earthquake. Moreover, injured adolescents and adolescents who lacked of physical exercise also need intervention due to high risk.
Suppression of lung inflammation in an LPS-induced acute lung injury model by the fruit hull of Gleditsia sinensis
Authors: Kim Kyun Ha , Kwun Min Jung , Han Chang Woo , Ha Ki-Tae , Choi Jun-Yong , Joo Myungsoo 
Published: October 2014

Abstract

Background
The fruit hull of Gleditsia sinensis (FGS) used in traditional Asian medicine was reported to have a preventive effect on lung inflammation in an acute lung injury (ALI) mouse model. Here, we explored FGS as a possible therapeutics against inflammatory lung diseases including ALI, and examined an underlying mechanism for the effect of FGS.

Methods
The decoction of FGS in water was prepared and fingerprinted. Mice received an intra-tracheal (i.t.) FGS 2 h after an intra-peritoneal (i.p.) injection of lipopolysaccharide (LPS). The effect of FGS on lung inflammation was determined by chest imaging of NF-κB reporter mice, counting inflammatory cells in bronchoalveolar lavage fluid, analyzing lung histology, and performing semi-quantitative RT-PCR analysis of lung tissue. Impact of Nrf2 on FGS effect was assessed by comparing Nrf2 knockout (KO) and wild type (WT) mice that were treated similarly.

Results
Bioluminescence from the chest of the reporter mice was progressively increased to a peak at 16 h after an i.p. LPS treatment. FGS treatment 2 h after LPS reduced the bioluminescence and the expression of pro-inflammatory cytokine genes in the lung. While suppressing the infiltration of inflammatory cells to the lungs of WT mice, FGS post-treatment failed to reduce lung inflammation in Nrf2 KO mice. FGS activated Nrf2 and induced Nrf2-dependent gene expression in mouse lung.

Conclusions
FGS post-treatment suppressed lung inflammation in an LPS-induced ALI mouse model, which was mediated at least in part by Nrf2. Our results suggest a therapeutic potential of FGS on inflammatory lung diseases.
The role of EBV in the pathogenesis of Burkitt’s Lymphoma: an Italian hospital based survey
Authors: Pannone Giuseppe , Zamparese Rosanna , Pace Mirella , Pedicillo Maria Carmela , Cagiano Simona , Somma Pasquale , Errico Maria Elena , Donofrio Vittoria , Franco Renato , De Chiara Annarosaria , Aquino Gabriella , Bucci Paolo , Bucci Eduardo , Santoro Angela , Bufo Pantaleo 
Published: October 2014

Abstract
The exact worldwide incidence of Burkitt’s lymphoma is not known. There are three distinct clinical variants of Burkitt’s lymphoma, each manifesting differences in epidemiology, clinical presentation, morphology, biology and genetic features: the endemic (African), the sporadic (non-endemic), and the immunodeficiency-associated form. In particular, we reported data regarding Burkitt’s lymphoma incidence in the world and across different European countries. Finally, we described clinic-pathological data of 48 Burkitt’s lymphomas occurred in Italy from 2003 to 2013, in 4 different hospitals, two of which located in east side, and the other ones located in the west-coast. Forty Burkitt’s lymphomas occurs in children (age range 3–12), and 8 were adulthood Burkitt’s lymphomas (age range 18–87). In the pediatric group the Male:Female ratio (M:F) was of 4:1, whereas the group of the adult patients has a M:F of 1:1.67. Immunohistochemical detection of Latent Membrane Protein 1 (LMP1) expression and Epstein-Barr virus Encoded RNA (EBER) In Situ Hybridization (ISH) procedures have been performed. Lymphocyte B monoclonal spread has been demonstrated using a Polymerase Chain Reaction (PCR) based method to amplify Fragment Restriction FR1, FR2 and FR3 immunoglobulin heavy chains DNA fragments. Only 38 cases out of 48 were analyzed for LMP-1 showing various percentage of stained cells in 47.4% of the patients.
Considering ISH for EBER detection results:
– 1 out 2 (50%) adult analyzed cases was positive, with 50% of stained tumor cells (this patient was a 22 years old female, coming from Napoli);
– 15 out 24 (62.5%) children analyzed Burkitt’s lymphomas resulted as positive for EBER;
– the overall positivity has been observed in 16/26 Burkitt’s lymphomas (61.53%).
– Finally, EBV has been detected in children and adult patients, one of them with deregulation of the oncogene c-MYC by chromosomal translocation.
Extracting ore-deposit-controlling structures from aeromagnetic, gravimetric, topographic, and regional geologic data in western Yukon and eastern Alaska
Authors: Sánchez Matías G. , Allan Murray M. , Hart Craig J. R. , Mortensen James K. 
Published: October 2014

Aeromagnetic lineaments interpreted from reduced-to-pole (RTP) magnetic grids were compared with gravity, topography, and field-based geologic maps to infer regional structural controls on hydrothermal mineral occurrences in a poorly exposed portion of the North American Cordillera in western Yukon and eastern Alaska. High-frequency and variable-intensity aeromagnetic lineaments corresponding to discontinuities with an aeromagnetic domain change were interpreted as steep-dipping and either magnetite-destructive or magnetite-additive faults. These structures were interpreted to be predominantly Cretaceous in age and to have formed after the collision of the Intermontane terranes with the ancient Pacific margin of North America. To demonstrate the reliability of the aeromagnetic interpretation, we developed a multidata set stacking methodology that assigns numeric values to individual lineaments depending on whether they can be traced in residuals and first vertical derivative of RTP aeromagnetic grids, isostatic residual gravity grids, digital topography, and regional geologic maps. The sum of all numeric values was used to estimate the likelihood of the aeromagnetic lineament as a true geologic fault. Fault systems were interpreted from zones of lineaments with high spatial density. Using this procedure, 10 major northwest-trending fault systems were recognized. These were oriented subparallel to the regional Cordilleran deformation fabric, the mid-Cretaceous Dawson Range magmatic arc, and well-established crustal-scale dextral strike-slip fault systems in the area. These orogen-parallel fault systems were interpreted to play a structural role in the emplacement of known porphyry Cu-Au and epithermal Au systems of mid-Cretaceous (115–98 Ma) and Late Cretaceous (79–72 Ma) age. The procedure also identified seven northeast-trending, orogen-perpendicular fault-fracture systems that are prominent in eastern Alaska and exhibit sinistral-to-oblique extensional kinematics. These structures were interpreted to govern the emplacement of Late Cretaceous (72–67 Ma) porphyry Mo- and Ag-rich polymetallic vein and carbonate replacement systems in the region.
The Sacrificial Ritual in Homer
Authors: Bednarek Bartłomiej 
Published: October 2014

Sacrificial Ritual in Homer
The paper discusses the model of interpretation of the Greek sacrificial ritual and proposes some changes and adjustment in the currently accepted paradigm. The main suggestion presented here is that the ritual slaughter of animals, as described in the Homeric poems, can be treated by protagonists as the practice of great practical impact (it provides the heroes with food) rather than that of a symbolic value.
Das Erhabene als literarisch-ästhetische Kategorie
Authors: Styka Jerzy 
Published: October 2014

The Sublime as a Literary-Aesthetic Category
The paper discusses the rhetorical and literary concept of the sublime (tὸ u`qos) and its development in the theory and practice of the ancient Greeks and Romans. Special emphasis is put on pseudo-Longinus' treatise De sublimitate and its understanding of the concept of the sublime.
Descriptive Criteria of nominal inflectional categories in Ancient Greek Grammar
Authors: Wolanin Hubert 
Published: October 2014

Descriptive Criteria of nominal inflectional categories in Ancient Greek Grammar
The present paper analyses the methodology adopted in the ancient Greek grammatical tradition to define and describe the nominal inflectional categories, i.e. gender, number, and case. The main source for the said analysis is the treatise Tekhne grammatike attributed to Dionysius Thrax, but references are also made to the works of Aristotle and some other authors. The research shows that semantic (functional) criteria played the principal part in describing the nominal inflectional categories, and especially that of the case. This does not mean, however, that the formal factor was completely absent: Aristotle’s determination in searching for formal criteria of gender classes of nouns is noteworthy in this respect, as well as the attempt to associate thenumber category with some formal factors, evidenced in the Tekhne.
Ocular involvement in systemic lupus erythematosus: implications for ophthalmic nursing practice
Authors: Jaiyesimi Stella , Gregg Emma , Barket Cynthia , Seewoodhary Ramesh 
Published: October 2014

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect any part of the body and lead to the development of sight-threatening eye complications. The ophthalmic nurse's role is important in the early identification and management of patients who present with ocular manifestations. After diagnosis, patient education and family involvement are both essential on an ongoing basis, and ophthalmic nurses play a vital role in this. This empowerment will help patients to selfcare and be in control of the disease. The care of patients who have developed eye complications can be very challenging, and patient care must be individualised as the symptoms and complications vary from patient to patient. This article discusses the epidemiology, pathogenesis, and ophthalmic complications of SLE, and the ophthalmic nurse's role in managing this condition.
Service evaluation of child chalazion management: an orthoptist-led clinic
Authors: Bedi Kaveeta Kaur , Pilling Rachel 
Published: October 2014

Background/Aim: In November 2012, a new patient pathway was introduced in the management of paediatric chalazion at the Bradford Royal Infirmary (BRI), UK. In the new pathway, children aged two to 16 years referred by their GP to an ophthalmologist for chalazion treatment were seen, examined and managed by an orthoptist within four weeks of referral, reducing referral to treatment waiting times by half. This study aims to evaluate: new pathway utilisation; the management received from each appointment; and the overall impact of the new system. Methods: This retrospective study looked at all paediatric patients (n=24) referred to the Paediatric Ophthalmology Department at the BRI between November 2012 and November 2013. Results: Approximately 91.7% (n=22) of referrals were seen by an orthoptist. Of these, 77.3% (n=17) required no further care and were not seen again for any ongoing problems. Care or treatment of those referred to an ophthalmologist was not delayed by seeing an orthoptist at first visit. This service resulted in a reduction of 34 appointments in the ophthalmologist clinic. Conclusions: This study demonstrates that organisational change can be rapidly implemented and well accepted when driven by good leadership and management. The new patient pathway also shows that savings can be made without a reduction in costs, while ensuring patient safety.
Access to a local Digital Diabetic Retinopathy Screening Service
Authors: Hirji Nizar K , Myers Paulette 
Published: October 2014

Background: Diabetic retinopathy is the second most frequent cause of registerable blindness in the working-age population in the UK. Despite the implementation of the NHS Diabetic Eye Screening Programme in England and Wales, many patients with diabetes continue to become sight impaired. Aim: The purpose of this study was to better understand the impact of a Digital Diabetic Retinopathy Screening Service (DDRSS) provided to residents of Walsall in the West Midlands, UK. Methods: An analysis of data from the UK National Diabetes Audit and a plot of the location of DDRSS providers against a ‘heat map’ of the resident population density of those aged 60 years and over in Walsall provided a gauge of the impact of the service, including accessibility to and reach of the service. Results: DDRSS providers were not necessarily located in residential areas of older people, nor within a 15-minute walking distance for a significant proportion of residents. The DDRSS pathway extensively involves community optometrists but appears to under-deliver in meeting the key performance indicators of the service. Conclusions: There is a need to better understand the barriers to the uptake of the DDRSS in Walsall. The feasibility of a mobile DDRSS service is also being considered so that the areas not within easy access of residents can be provided with the screening service. Further consideration should be given to the provision of the service to patients in their homes, and in residential homes and day-care centres.
The Community Health Applied Research Network (CHARN) Data Warehouse: a Resource
for Patient-Centered Outcomes Research and Quality Improvement in Underserved, Safety
Net Populations
Authors: Laws Reesa , Gillespie Suzanne , Puro Jon , Van Rompaey Stephan , Quach Thu , Carroll Joseph , Chang Weir Rosy , Crawford Phil , Grasso Chris , Kaleba Erin , McBurnie Mary Ann 
Published: October 2014

Background: The Community Health Applied Research Network, funded by the Health
Resources and Services Administration, is a research network comprising 18 Community
Health Centers organized into four Research Nodes (each including an academic partner)
and a data coordinating center. The network represents more than 500,000 diverse safety
net patients across 11 states.Objective: The primary objective of this paper is to
describe the development and implementation process of the CHARN data
warehouse.Methods: The methods involved regulatory and governance development and
approval, development of content and structure of the warehouse and processes for
extracting the data locally, performing validation, and finally submitting data to the
data coordinating center.Progress to Date: Version 1 of the warehouse has been
developed. Tables have been added, the population and the years of electronic health
records (EHR) have been expanded for Version 2.Conclusions: It is feasible to create a
national, centralized data warehouse with multiple Community Health Center partners
using different EHR systems. It is essential to allow sufficient time: (1) to develop
collaborative, trusting relationships among new partners with varied technology,
backgrounds, expertise, and interests; (2) to complete institutional, business, and
regulatory review processes; (3) to identify and address technical challenges associated
with diverse data environments, practices, and resources; and (4) to provide continuing
data quality assessments to ensure data accuracy.
Fungus-Modified Lignin and Its Use in Wood Adhesive for Manufacturing Wood Composites*
Authors: Zhang Yaolin , Yang Dian-Qing , Wang Xiang-Ming , Feng Martin , He Guangbo 
Published: October 2014

Abstract
Organosolv lignins were modified with different fungal species. The modified lignins were used as raw materials for preparing lignin-phenol-formaldehyde (LPF) resins. Oriented strandboard (OSB) panels were produced with these laboratory-synthesized LPF resins for evaluating the bond performance of the LPF resins in the manufacturing of wood composites. Ultraviolet spectroscopy results show that the phenolic hydroxyl contents in the lignins were changed after the lignins were treated with fungi. The lignin modified with the brown-rot fungi extended the gel time of the LPF resin compared with the corresponding unmodified lignin, while the lignin modified with the white-rot fungi shortened the gel time. The OSB test results show that the internal bond strength and the bending properties of the panels bonded with the LPF resins containing the modified lignin were comparable to or better than those of the panels bonded with the commercial phenolic resin or the LPF resin containing the unmodified lignin. It is worth noting that the fungi-modified lignin reduced the thickness swell and water absorption of the OSB panels, implying the water resistance of the LPF resins was improved with the fungi-modified lignin. It is also suggested that up to 50 percent of phenol can be potentially replaced with fungi-modified lignin in phenolic resins used as wood adhesives.
The eAutopsy
Authors: Talmon Geoffrey A. , Czarnecki Donna , Bernal Kerry 
Published: October 2014

Abstract

Objectives:
One reason for declining autopsy numbers is clinicians’ lack of familiarity with the practice. We developed an online tool used in place of attending postmortem examinations and aimed to determine if the experience was as effective in affecting medical students’ attitudes toward the procedure.

Methods:
The eAutopsy was a part of a unit consisting of a mixture of a didactic lecture, readings, and online discussion board. A class of second-year medical students was randomly distributed between autopsy attendance and the eAutopsy, afterward completing a Likert-type attitudinal survey. Responses were compared with previous students receiving only a lecture.

Results:
Thirty students attended a “live” autopsy, 90 completed the eAutopsy, and 47 students from the prior year completed the survey. Responses between all three were statistically similar for all but one item. The live and eAutopsy groups would be significantly more comfortable asking for an autopsy in the future. Narrative responses indicated that while the eAutopsy was effective in delivering information, some noticed the lack of emotional impact.

Conclusions:
The two forms of autopsy exposure performed similarly on a Likert-type survey assessing certain attitudes related to the procedure. However, the emotional impact of the live experience may be longer lasting.