bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical Digital Literacies among Youth: From Food Eating Contests to Societal Transformation
Authors: Unadkat Devanshi , Hull Glynda 
Published: August 2024

AbstractIn this chapter we trace the development of students’ critical digital literacies as they create and share digital stories. This project was carried out by a team of researchers, teachers, undergraduate and graduate students, and community partners with the UC Links network. Through a curriculum rooted in developing critical imaginings of self, others, and their local and global communities, students’ composition practices shifted from being centered on topics that were considered “viral” to ones that were more rooted in addressing social issues. We explore how the curriculum supported these shifts in students’ stories and the powerful narratives they crafted through this renewed curriculum.
Math CEO: A Mutually Beneficial Partnership between College Mentors and Latinx Youths
Authors: Pantano Alessandra 
Published: August 2024

AbstractThe UC Irvine Math Community Educational Outreach program (Math CEO) is a university-community partnership that connects faculty and students at the University of California, Irvine, with Latinx families in Santa Ana, California. The program offers weekly after-school math enrichment sessions and STEM-focused field trips for middle school students, as well as college-orientation workshops for caregivers. In this chapter, we focus on Math CEO’s intentional efforts to create an inclusive community of learners, both in in-person and virtual modalities (the latter practiced during the COVID-19 pandemic from 2020–22). Drawing on different perspectives—from college students, youths, and caregivers alike—we link these efforts to specific program outcomes.
Triple-gauge couplings in LHC diboson production: a SMEFT view from every angle
Authors: El Faham Hesham , Pelliccioli Giovanni , Vryonidou Eleni 
Published: August 2024

Abstract
This study explores fully leptonic WZ and WW production at the LHC within the SMEFT framework at NLO in QCD, focusing on both CP-even and CP-odd triple-gauge-coupling dimension-six operators. We investigate the off-shell processes, contrasting our findings in inclusive setups with those in the presence of realistic fiducial selections. Alongside the conventional kinematic observables, we examine polarisation-sensitive observables and angular coefficients. Moreover, we assess potential SMEFT effects on asymmetry observables. Through a sensitivity analysis, we identify critical LHC observables that are particularly sensitive to SMEFT-induced modifications, thereby shedding light on potential avenues for new physics searches in diboson production at the LHC.
Evaluation of atmospheric-plasma-source absorption mode Fourier transform Orbitrap mass spectrometry for chlorinated paraffin mixtures
Authors: Masucci Claudia , Nagornov Konstantin O. , Kozhinov Anton N. , Kraft Kevin , Tsybin Yury O. , Bleiner Davide 
Published: August 2024

AbstractChlorinated paraffins (CP) are complex molecular mixtures occurring in a wide range of isomers and homologs of environmental hazards, whose analytical complexity demand advanced mass spectrometry (MS) methods for their characterization. The reported formation of chlorinated olefins (COs) and other transformation products during CP biotransformation and degradation can alter the MS analysis, increasing the high resolution required to distinguish CPs from their degradation products. An advanced setup hyphenating a plasma ionization source and an external high-performance data acquisition and processing system to the legacy hybrid LTQ Orbitrap XL mass spectrometer is reported. First, the study demonstrated the versatility of a liquid sampling atmospheric pressure glow discharge, as a soft ionization technique, for CP analysis. Second, enhanced resolution and sensitivity provided by the absorption mode Fourier transform spectral representation on this legacy mass spectrometer are shown. The developed Orbitrap-based platform allowed the detection of new isotopic clusters and CPs and COs to be distinguished at medium resolution (setting 30,000 at m/z 400, ~ 400 ms transients), and even chlorinated di-olefins (CdiOs) at higher resolution (setting 100,000 at m/z 400, ~ 1500 ms transients). Overall, such proof-of-principle instrumental improvements are promising for environmental and analytical research in the field of CP analysis.
Graphical Abstract
Local Solutions of RG Flow Equations from the Nash–Moser Theorem
Authors: D’Angelo Edoardo , Pinamonti Nicola 
Published: August 2024

AbstractWe prove local existence of solutions of a functional renormalisation group equation for the effective action of an interacting quantum field theory, when a suitable local potential approximation is considered. To obtain this equation in a Lorentzian setting a quantum state for the theory is selected and a regulator consisting in a mass is added to the action. The flow equation for mass rescalings is then studied using the renown Nash–Moser theorem.
Characteristics of isoniazid-induced psychosis: a systematic review of case reports and case series
Authors: B Keerthanaa , Appaji Rashmi , Thomas Levin , Baral Tejaswini , N Skanda , Chaithra  , M Sonal Sekhar , Saravu Kavitha , Undela Krishna , Rao Mahadev 
Published: August 2024

Abstract
Purpose
Isoniazid, a first-line antitubercular drug, is associated with nervous system adverse drug reactions such as seizures, peripheral neuropathy, and psychosis. This systematic review of case reports and case series aimed to characterize the demographic, social, and clinical factors associated with isoniazid-induced psychosis in patients with active tuberculosis (TB) and those who received isoniazid for latent TB infection (LTBI).

Methods
We comprehensively searched the Embase, PubMed, and Scopus databases to identify relevant studies published between the date of inception of the database and June 2024.

Results
A total of 28 studies, including 21 case reports and 7 case series involved 37 patients who developed isoniazid-induced psychosis. A higher frequency of isoniazid-induced psychosis was observed during the first 2 months of treatment, with a relatively early onset observed among patients aged 18 years or less. Delusions and/or hallucinations are the common symptoms of isoniazid-induced psychosis. Psychomotor disturbances, disorganized speech or formal thought disorder, disorganized or abnormal behaviour, and neuropsychiatric symptoms (sleep disturbances, hostility or aggression, confusion, affective symptoms, anxiety symptoms, and cognitive difficulties) were the other symptoms observed in the included studies. More than 80% of cases rechallenged with isoniazid resulted in the recurrence of psychotic symptoms.

Conclusion
Patients with TB and LTBI should be assessed for psychotic and neuropsychiatric symptoms during isoniazid therapy, mainly in the first 2 months. Further research is required to understand the impact of underlying risk factors, such as genetic predisposition and isoniazid pharmacokinetics, as well as the clinical utility and dosage recommendations of pyridoxine for managing isoniazid-induced psychosis.
ESR Essentials: response assessment criteria in oncologic imaging—practice recommendations by the European Society of Oncologic Imaging
Authors: Zamboni Giulia A. , Cappello Giovanni , Caruso Damiano , Gourtsoyianni Sofia , Cyran Clemens , Schlemmer Heinz-Peter , D’Anastasi Melvin , Fournier Laure , Neri Emanuele 
Published: August 2024

Abstract
Assessing the response to oncological treatments is paramount for determining the prognosis and defining the best treatment for each patient. Several biomarkers, including imaging, can be used, but standardization is fundamental for consistency and reliability. Tumor response evaluation criteria have been defined by international groups for application in pharmaceutical clinical trials evaluating new drugs or therapeutic strategies. RECIST 1.1 criteria are exclusively based on unidimensional lesion measurements; changes in tumor size are used as surrogate imaging biomarkers to correlate with patient outcomes. However, increased tumor size does not always reflect tumor progression. The introduction of immunotherapy has led to the development of new criteria (iRECIST, Level of Evidence (LoE) Ib) that consider the possibility that an increase in disease burden is secondary to the immune response instead of progression, with the new concept of Unconfirmed Progressive Disease (a first progression event which must be confirmed on follow-up). Specific criteria were devised for HCC (mRECIST, LoE IV), which measure only enhancing HCC portions to account for changes after local therapy. For GIST treated with imatinib, criteria were developed to account for the possible increase in size reflecting a response rather than a progression by assessing both tumor size and density on CT (Choi, LoE II). This article provides concise and relevant practice recommendations aimed at general radiologists to help choose and apply the most appropriate criteria for assessing response to treatment in different oncologic scenarios. Though these criteria were developed for clinical trials, they may be applied in clinical practice as a guide for day-to-day interpretation.

Key Points

Response evaluation criteria, designed for use in clinical trials, might serve as a surrogate biomarker for overall survival.

RECIST 1.1 defines measurable and non-measurable disease among which target lesions and non-target lesions are selected at baseline as reference for follow-ups.

Some therapies and/or cancers require the use of different criteria, such as iRECIST, mRECIST, and Choi criteria.
Continental scale spatial temporal interpolation of near-surface air temperature: do 1 km hourly grids for Australia outperform regional and global reanalysis outputs?
Authors: Stewart Stephen B. , McVicar Tim R. , Van Niel Thomas G. , Cai Dejun 
Published: August 2024

AbstractNear-surface air temperature is an essential climate variable for the study of many biophysical phenomena, yet is often only available as a daily mean or extrema (minimum, maximum). While many applications require sub-diurnal dynamics, temporal interpolation methods have substantial limitations and atmospheric reanalyses are complex models that typically have coarse spatial resolution and may only be periodically updated. To overcome these issues, we developed an hourly air temperature product for Australia with spatial interpolation of hourly observations from 621 stations between 1990 and 2019. The model was validated with hourly observations from 28 independent stations, compared against empirical temporal interpolation methods, and both regional (BARRA-R) and global (ERA5-Land) reanalysis outputs. We developed a time-varying (i.e., time-of-day and day-of-year) coastal distance index that corresponds to the known dynamics of sea breeze systems, improving interpolation performance by up to 22.4% during spring and summer in the afternoon and evening hours. Cross-validation and independent validation (n = 24/4 OzFlux/CosmOz field stations) statistics of our hourly output showed performance that was comparable with contemporary Australian interpolations of daily air temperature extrema (climatology/hourly/validation: R2 = 0.99/0.96/0.92, RMSE = 0.75/1.56/1.78 °C, Bias = -0.00/0.00/-0.03 °C). Our analyses demonstrate the limitations of temporal interpolation of daily air temperature extrema, which can be biased due to the inability to represent frontal systems and assumptions regarding rates of temperature change and the timing of minimum and maximum air temperature. Spatially interpolated hourly air temperature compared well against both BARRA-R and ERA5-Land, and performed better than both reanalyses when evaluated against the 28 independent validation stations. Our research demonstrates that spatial interpolation of sub-diurnal meteorological fields, such as air temperature, can mitigate the limitations of alternative data sources for studies of near-surface phenomena and plays an important ongoing role in supporting numerous scientific applications.
Switching from inotersen to eplontersen in patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: analysis from NEURO-TTRansform
Authors: Conceição Isabel , Berk John L. , Weiler Markus , Kowacs Pedro A. , Dasgupta Noel R. , Khella Sami , Chao Chi-Chao , Attarian Shahram , Kwoh T. Jesse , Jung Shiangtung W. , Chen Jersey , Viney Nicholas J. , Yu Rosie Z. , Gertz Morie , Masri Ahmad , Cruz Márcia Waddington , Coelho Teresa 
Published: August 2024

Abstract

Background
The phase 3 NEURO-TTRansform trial showed eplontersen treatment for 65 weeks reduced transthyretin (TTR), halted progression of neuropathy impairment, and improved quality of life (QoL) in adult patients with hereditary TTR-mediated amyloidosis with polyneuropathy (ATTRv-PN), vs. historical placebo.

Methods
NEURO-TTRansform enrolled patients with ATTRv-PN. A subset of patients were randomized to receive subcutaneous inotersen 300 mg weekly (Weeks 1–34) and subsequently switched to subcutaneous eplontersen 45 mg every 4 weeks (Weeks 37–81). Change in serum TTR and treatment-emergent adverse events (TEAEs) were evaluated through Week 85. Effects on neuropathy impairment, QoL, and nutritional status were also evaluated.

Results
Of 24 patients randomized to inotersen, 20 (83%) switched to eplontersen at Week 37 and four discontinued due to AEs/investigator decision. Absolute change in serum TTR was greater after switching from inotersen (−74.3%; Week 35) to eplontersen (−80.6%; Week 85). From the end of inotersen treatment, neuropathy impairment and QoL were stable (i.e., did not progress) while on eplontersen, and there was no deterioration in nutritional status. TEAEs were fewer with eplontersen (Weeks 37–85; 19/20 [95%] patients) compared with inotersen (up to Week 35; 24/24 [100%] patients). Mean platelet counts decreased during inotersen treatment (mean nadir reduction ‒40.7%) and returned to baseline during eplontersen treatment (mean nadir reduction, ‒3.2%).

Conclusions
Switching from inotersen to eplontersen further reduced serum TTR, halted disease progression, stabilized QoL, restored platelet count, and improved tolerability, without deterioration in nutritional status. This supports a positive benefit-risk profile for patients with ATTRv-PN who switch from inotersen to eplontersen.
The interaction between miR165/166 and miR160 regulates Arabidopsis thaliana seed size, weight, and number in a ROS-dependent manner
Authors: Pawłasek Natalia , Sokołowska Anna , Koter Marek , Oracz Krystyna 
Published: August 2024

Abstract
Main conclusion
Our data link the miR165/166- and miR160-mediated regulatory modules to ROS and seed formation. Trade-offs of seed size, weight, and number probably require control of the expression of miR165/166 by miR160, modulation of ROS metabolism by miR165/166, and miR160 abundance by ROS-induced oxidative modifications

Abstract
The cycle of plant life and its yield productivity depends fundamentally on the establishment of the trade-offs of seed size, weight, and number. For annual plants, seed number should simply be a positive function of vegetative biomass and a negative function of seed size and/or weight. However, extensive natural variation within species is observed for these traits, for which an optimal solution is environmentally dependent. Understanding the miRNA-mediated post-transcriptional regulation of gene expression determining seed phenotype and number is crucial from both an evolutionary and applied perspective. Although extensive research has concentrated on the individual roles of miRNAs in plant life, fewer studies have centred on their functional interactions, hence this study aimed to examine whether the module of miR165/miR166 and/or miR160 interactions is involved in forming Arabidopsis thaliana seeds, and/or has an impact on their features. Considering that reactive oxygen species (ROS) are among key players in seed-related processes, it was also intriguing to verify if the mechanism of action of these miRNAs is associated with the ROS pathway. The plant material used in this study consisted of flower buds, green siliques, and freshly harvested seeds, of wild type (WT), and STTM165/166 and STTM160 × 165/166 mutants of A. thaliana plants which are powerful tools for functional analysis of miRNAs in plants. The novel results obtained during physiological phenotyping together with two-tailed qRT-PCR analysis of mature miR165, miR166, miR160, and spectrofluorimetric measurement of apoplastic hydrogen peroxide (H2O2) for the first time revealed that interaction between miR165/miR166 and miR160 may regulate seed size, weight and number in ROS-dependent manner.
Clozapine-associated adverse drug reactions in 38,349 psychiatric inpatients: drug surveillance data from the AMSP project between 1993 and 2016
Authors: Bleich Lene , Grohmann Renate , Greil Waldemar , Dabbert Dominik , Erfurth Andreas , Toto Sermin , Seifert Johanna 
Published: August 2024

AbstractClozapine is a second-generation antipsychotic drug that offers superior treatment results in patients with schizophrenia but is also associated with significant risks. This study analyzes data on pharmacotherapy with clozapine and the associated adverse drug reactions (ADRs) in an inpatient setting including 38,349 patients. Data about the use of clozapine and reports of severe ADRs within the period 1993–2016 were obtained from the multicentered observational pharmacovigilance program “Arzneimittelsicherheit in der Psychiatrie” (AMSP). In total, 586 severe clozapine-associated ADRs were documented (1.53% of all patients exposed). Patients aged ≥65 years had a higher risk of ADRs than patients aged <65 years (1.96 vs. 1.48%; p = 0.021). Significantly more ADRs were attributed to clozapine alone (396; 67.6% of all 586 ADRs) than to a combination with other drugs. The most frequent ADRs were grand mal seizures (0.183% of all 38,349 patients exposed), delirium (0.180%), increased liver enzymes (0.120%), and agranulocytosis (0.107%). We detected 24 cases (0.063%) of clozapine-induced extrapyramidal symptoms, of which 8 (0.021%) were attributed to clozapine alone. Five ADRs resulted in death (0.013%): 2 due to agranulocytosis (41 cases total) (mortality = 4.88%) and 3 due to paralytic (sub)ileus (16 cases) (mortality = 18.75%). The median dose of clozapine in all patients treated was 300 mg/day, in patients who developed ADRs 250 mg/day. The main risk factor for an ADR was pre-existing damage of the affected organ system. Overall, the results of this study highlight the importance of alertness—especially of frequently overlooked symptoms—and appropriate monitoring during treatment with clozapine, even at low doses.
Serial visual reversal learning in captive black-handed spider monkeys, Ateles geoffroyi
Authors: Dorschner Jules , Hernandez Salazar Laura Teresa , Laska Matthias 
Published: August 2024

Abstract
Recent research suggests that socio-ecological factors such as dietary specialization and social complexity may be drivers of advanced cognitive skills among primates. Therefore, we assessed the ability of 12 black-handed spider monkeys (Ateles geoffroyi), a highly frugivorous platyrrhine primate with strong fission-fusion dynamics, to succeed in a serial visual reversal learning task. Using a two-alternative choice paradigm we first trained the animals to reliably choose a rewarded visual stimulus over a non-rewarded one. Upon reaching a pre-set learning criterion we then switched the reward values of the two stimuli and assessed if and how quickly the animals learned to reverse their choices, again to a pre-set learning criterion. This stimulus reversal procedure was then continued for a total of 80 sessions of 10 trials each. We found that the spider monkeys quickly learned to reliably discriminate between two simultaneously presented visual stimuli, that they succeeded in a visual reversal learning task, and that they displayed an increase in learning speed across consecutive reversals, suggesting that they are capable of serial reversal learning-set formation with visual cues. The fastest-learning individual completed five reversals within the 80 sessions. The spider monkeys outperformed most other primate and nonprimate mammal species tested so far on this type of cognitive task, including chimpanzees, with regard to their learning speed in both the initial learning task and in the first reversal task, suggesting a high degree of behavioral flexibility and inhibitory control. Our findings support the notion that socio-ecological factors such as dietary specialization and social complexity foster advanced cognitive skills in primates.
Student’s reported satisfaction at University: the role of personal characteristics and secondary school background
Authors: Li Ian W. , Jackson Denise , Koshy Paul 
Published: August 2024

AbstractWidening participation and improving outcomes for under-represented and disadvantaged groups in higher education are part of the strategic agenda of governments across the globe. A critical aspect of this challenge is enhancing the experience of students from such backgrounds. However, there is relatively limited evidence on the effects of student background, including social and geographical disadvantage and secondary education preparation, on self-reported student experience. This study addressed this topic in the Australian context using data from the annual Student Experience Survey (2016–2020 waves) with linkage to administrative records for 24,292 students from seven higher education institutions. This included data on secondary schools’ administration, resourcing, and socio-economic status from the Australian Curriculum, Assessment and Reporting Authority. Binary logistic regression models were estimated on eight measures of self-reported student satisfaction, and a measure of dropout risk. Students from equity groups, particularly those with a disability or from non-English speaking backgrounds, were found to have lower levels of student satisfaction in aspects of their higher education experience and higher risk of dropout. Those from non-government schools (privately funded) reported higher levels of student satisfaction. Off-campus study was associated with poorer satisfaction but lower risk of dropout, while being engaged in some online study was associated with better satisfaction. The findings indicate the need for better university support for equity group students and signal potential responses through university study design, such as incorporating online study options, and addressing issues faced by students studying off-campus, to improve student outcomes.
A Cryogenic Testbed for Polarization Modulators and Cryogenic Mechanisms
Authors: Columbro F. , de Bernardis P. , Coppolecchia A. , Marchitelli E. , Masi S. , Occhiuzzi A. 
Published: August 2024

AbstractWe developed a cryogenic facility to assess the performance of different types of cryogenic mechanisms. The facility can host very large (up to $$\sim {1}\,\hbox {m}^{3}$$

∼
1

m
3

) and heavy (up to $$\sim {30}\,\hbox {kg}$$

∼
30

kg

) instrumentation, cooled down below 10 K. The operation of moving components can be visually monitored by means of two webcams looking inside the 4 K volume. In addition a large number of electrical feedthroughs (444 lines) allow the operation of a set of hall and capacitive sensors to measure both the magnetic field, the position of moving devices with an accuracy of tens of microns and their temperatures with an accuracy of few $$\%$$
%
. We present the results of the first tests on a large aperture (500 mm diameter) superconducting magnetic bearing for the SWIPE/LSPE experiment currently under test.