bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors influencing length of stay and suitability for early community discharge in the management of acute pyelonephritis
Authors: Hsu RCJ , Shergill P , Gnanapragasam VJ 
Published: October 2014

Objectives: We assessed factors influencing length of stay and suitability for early discharge to community care in acute pyelonephritis (APN). Methods: APN patients admitted in 2011–2012 to a tertiary hospital were included in a retrospective study. Data collected included patient demographics, Charlson Comorbidity Index (CCI), admitting speciality, imaging, length of stay and any intervention. Results: A total of 266 patients were analysed with 83.1% managed by urologists and the rest by other specialties. Urology patients had a shorter mean stay of 4.7 days compared to 8.8 days for non-urology patients ( p < 0.001). The mean time to imaging was 0.5 days and 1.4 days for urology and other specialties, respectively ( p < 0.001). Twenty per cent of patients had urinary tract abnormalities on imaging but only 2.0% required intervention; 9.4% (25/266) had repeated imaging following an initial scan but none resulted in an intervention. A high CCI was a predictor of longer stays regardless of admitting speciality ( p < 0.001). Admission to non-urological specialities remained a significant predictor both of delayed imaging ( p = 0.001) and longer stays ( p < 0.001) even after correction for CCI. Conclusion: Time to imaging, comorbidity and admitting speciality are key factors influencing APN management. Rapid urological review and imaging could identify patients suitable for safe early discharge to community management.
Long-term results of first salvage treatment in CLL patients treated initially with FCR (fludarabine, cyclophosphamide, rituximab)
Authors: Tam Constantine S. , O’Brien Susan , Plunkett William , Wierda William , Ferrajoli Alessandra , Wang Xuemei , Do Kim-Anh , Cortes Jorge , Khouri Issa , Kantarjian Hagop , Lerner Susan , Keating Michael J. 
Published: October 2014

Key PointsPatients who relapse within 3 years of frontline FCR therapy have poor survival when treated with conventional salvage regimens. Such patients are suitable for allogeneic stem cell transplantation and novel noncytotoxic therapies.
Coexistence of memory resistance and memory capacitance in TiO2 solid-state devices
Authors: Salaoru Iulia , Li Qingjiang , Khiat Ali , Prodromakis Themistoklis 
Published: October 2014

AbstractThis work exploits the coexistence of both resistance and capacitance memory effects in TiO2-based two-terminal cells. Our Pt/TiO2/TiOx/Pt devices exhibit an interesting combination of hysteresis and non-zero crossing in their current-voltage (I-V) characteristic that indicates the presence of capacitive states. Our experimental results demonstrate that both resistance and capacitance states can be simultaneously set via either voltage cycling and/or voltage pulses. We argue that these state modulations occur due to bias-induced reduction of the TiOxactive layer via the displacement of ionic species.
Novel Fluorine-containing Trisilahydrocarbon Lubricants and Their Antiatomic Oxygen Irradiation under Simulated Space
Authors: Wang Haizhong , Wang Xiaolong , Qiao Dan , Sun Xiaojun , Feng Dapeng , Liu Weimin 
Published: October 2014

Abstract
The novel fluorine-containing trisilahydrocarbon lubricants with methyl and 3,3,3-trifluoropropyl substituents (named SiFCH) were synthesized. Importantly, as potential aerospace lubricants, their chemical, physical, and tribological properties under simulated atomic oxygen (AO) exposure in space environment were investigated by a laboratory-built simulation multifunctional space tribo-tester system. The results showed that the SiFCH synthetic oils possess good physical properties and favorable tribological performance, which are superior to that of multi-alkylated cyclopentanes (MACs) in terms of frictional reduction and antiwear capacity under vacuum.
Probing the wound healing potential of biogenic silver nanoparticles
Authors: Dhapte V. , Kadam S. , Moghe A. , Pokharkar V. 
Published: October 2014

Objective: Silver nanoparticles (AgNPs) are known for their antimicrobial profile and wound healing activities. However, cytotoxicity and cosmetic abnormalities associated with silver pose a major challenge in their translation for therapeutic applications. Our objective was to develop biogenic AgNPs, using a single-step green synthesis, and to investigate their in vitro and in vivo behaviour as wound-healing agents. Method: AgNPs were prepared using the green synthesis approach with aqueous Bryonia laciniosa leaves extract. The AgNPs were then evaluated for physicochemical properties, stability, and antimicrobial and in vivo wound healing activities. Results: Stable AgNPs with characteristic absorption at 408nm and 15±3nm particle size were generated via the active involvement of Bryonia laciniosa. No loss of stability was detected after 6 months at room temperature. Antibacterial activity was observed against both Gram-negative and Gram-positive bacteria with no cytotoxicity observed in vitro at a concentration of 200 μg/mL and effective cytokine modulation. In vivo wound healing experiments showed improved wound contracting ability in rats where, after 14 days, wound alleviation was 47.1±2.2% in the control groups, compared with 78.1±1.4% and 92.6±6.7% for a silver-based marketed cream and the AgNPs, respectively. Conclusion: The developed AgNPs proved to be superior wound healing agents owing to scarless healing with insignificant inflammation and toxicity. Declaration of interest: There were no external sources of funding for this study. The authors have no conflicts of interest to declare.
Impact of compression therapy using Unna's boot on the self-esteem of patients with venous leg ulcers
Authors: Salome G.M. , de Brito M.J.A. , Ferreira L.M. 
Published: October 2014

• Objective: To assess self-esteem in patients with venous leg ulcers treated with Unna's boot. • Method: A descriptive, analytic, clinical study was conducted from June 2010 to May 2011 in an outpatient wound care clinic in São Paulo, Brazil. Patients of both sexes, aged ≥18 years, who had had a venous leg ulcer for more than one year and a Doppler ankle brachial index ranging from 0.8–1.0 were consecutively selected for inclusion. Patients were treated with wound dressings and Unna's boot. Self-esteem was assessed using the Brazilian version of the Rosenberg Self-Esteem Scale (RSE) at inclusion (baseline) and after 4, 8, and 12 months of compression therapy using Unna's boot. The scale is reverse-scored; thus lower scores indicate higher levels of self-esteem. • Results: The patients showed a slight but significant improvement in self-esteem after 4 months of treatment (mean RSE score=17.12) compared with baseline (mean RSE score=24.90). However, a marked and significant improvement in self-esteem was observed after 8 months (mean RSE score=7.40) and 12 months (mean RSE score=2.10) of compression therapy using Unna's boot. • Conclusion: Patients with venous leg ulcers treated with Unna's boot for 12 months showed a significant improvement in self-esteem • Declaration of interest: All authors declare that no competing financial interests exist. There was no external funding for this study.
VIDEOFLUOROSCOPIC SWALLOWING STUDY: esophageal alterations in patients with dysphagia
Authors: SCHEEREN Betina , MACIEL Antônio Carlos , BARROS Sérgio Gabriel Silva de 
Published: October 2014

Context Videofluoroscopic swallowing study is a dynamic exam and allows the evaluation of the complete swallowing process. However, most published studies have only reported alterations in the oropharynx and pharyngoesophageal transition, leaving the analysis of the esophagus as a secondary goal. Objectives The goal of this study was to investigate the prevalence of alterations in the esophageal phase thorough videofluoroscopic swallowing study in patients with dysphagia. Methods Consecutive patients with dysphagia who underwent videofluoroscopic swallowing study including esophageal analysis between May 2010 and May 2012 had their exams retrospectively reviewed. Patients were classified into two groups: Group I - without a pre-established etiological diagnosis and Group II - with neurological disease. During the exam, the patients ingested three different consistencies of food (liquid, pasty and solid) contrasted with barium sulfate and 19 items were analyzed according to a protocol. The esophageal phase was considered abnormal when one of the evaluated items was compromised. Results Three hundred and thirty-three (n = 333) consecutive patients were studied - 213 (64%) in Group I and 120 (36%) in Group II. Esophageal alterations were found in 104 (31%) patients, with a higher prevalence in Group I (36.2%), especially on the items esophageal clearance (16.9%) and tertiary contractions (16.4%). It was observed that 12% of individuals in Group I only presented alterations on the esophageal phase. Conclusion Evaluation of the esophageal phase of swallowing during videofluoroscopic swallowing study detects abnormalities in patients with cervical dysphagia, especially in the group without pre-established etiological diagnosis.
A Phase II Study of Ifosfamide, Methotrexate, Etoposide, and Prednisolone for Previously Untreated Stage I/II Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type: A Multicenter Trial of the Korean Cancer Study Group
Authors: Kim Tae Min , Kim Dong-Wan , Kang Yoon-Koo , Chung Jooseop , Song Hong-Suk , Kim Hyo Jung , Kim Byung Soo , Lee Jong-Seok , Kim Hawk , Yang Sung Hyun , Yuh Young Jin , Bae Sung Hwa , Hyun Myung Soo , Jeon Yoon Kyung , Kim Chul Woo , Heo Dae Seog 
Published: October 2014

Abstract

Background.
Combination chemotherapy consisting of ifosfamide, methotrexate, etoposide, and prednisolone (IMEP) was active as first-line and second-line treatment for extranodal natural killer/T-cell lymphoma (NTCL).

Methods.
Forty-four patients with chemo-naïve stage I/II NTCL were enrolled in a prospective, multicenter, phase II study and received six cycles of IMEP (ifosfamide 1.5 g/m2 on days 1–3; methotrextate 30 mg/m2 on days 3 and 10; etoposide 100 mg/m2 on days 1–3; and prednisolone 60 mg/m2 per day on days 1–5) followed by involved field radiotherapy (IFRT).

Results.
Overall response rates were 73% (complete remission [CR] in 11 of 41 evaluable patients [27%]) after IMEP chemotherapy and 78% (CR 18 of 27 evaluable patients [67%]) after IMEP followed by IFRT. Neutropenia and thrombocytopenia were documented in 33 patients (75%) and 7 patients (16%), respectively. Only 8 patients (18%) experienced febrile neutropenia. Three-year progression-free survival (PFS) and overall survival (OS) were 66% and 56%, respectively. High Ki-67 (≥70%) and Ann Arbor stage II independently reduced PFS (p = .004) and OS (p = .001), respectively.

Conclusion.
Due to the high rate of progression during IMEP chemotherapy, IFRT needs to be introduced earlier. Moreover, active chemotherapy including an l-asparaginase-based regimen should be use to reduce systemic treatment failure in stage I/II NTCL.
Petites natures - enquête
Authors: Easterman-Ulmann Rachel , Bonifassi Catherine , Ildefonse Frédérique , Renouard Jean-Philippe 
Published: October 2014

Résumé	« Un scorpion veut traverser le fleuve. Mais il ne sait pas nager. Il avise un hippopotame et lui demande : — Puis-je monter sur ton dos pour traverser le fleuve ? L’hippopotame lui répond : — Tu me prends pour un imbécile ? Si je te prends sur mon dos pour traverser le fleuve, tu vas me piquer, et je mourrai. — Mais non, dit le scorpion, car si je te pique, je vais me noyer. — D’accord, dit l’hippopotame. Le scorpion grimpe sur son dos, et ils entament la traversée. Au milieu du fleuve, le scorpion pique l’hippopotame. — Qu’est-ce qui t’a pris ? dit l’hippopotame, en sombrant. Tu vas mourir aussi. — Je n’y peux rien, dit le scorpion. C’est ma nature. » Nous avons adressé quatre questions à différentes personnes qui, par leurs activités, sont confrontées d’une manière ou d’une autre à la nature.
Les fécondations artificielles, le droit et la nature
Authors: Iacub Marcela 
Published: October 2014

Résumé Les lois bioéthiques semblent avoir adopté à l’égard des techniques de procréation artificielle une position paradoxale. Elles n’interdissent d’emblée aucune des techniques procréatives présentes ou futures (hormis les maternités de substitution et l’ectogénèse). Elles ont le souci de faire croire que les enfants nés par cette voie sont conçus par la voie sexuelle ; que la nature n’a pas été troublée.
Un franc-tireur minuscule
Authors: Saint-Saëns Isabelle , Revel Jeanne , Perrier Jean-François 
Published: October 2014

Résumé Dans Vacarme n? 13, nous avions publié un dossier sur le 17 octobre 1961. Ce n’est pas uniquement parce que nous avons l’esprit d’escalier que nous revenons cette fois-ci à la charge, en interrogeant Robert Bonnaud. Historien des cycles, il s’intéresse aux tournants de l’histoire universelle, aux « régressions, au non-progrès, aux zigzags » comme en témoignent Le Système de l’histoire (Fayard) et Tournants et périodes (Kimé). Il aime aussi à se définir comme un témoin engagé : rappelé en Algérie en 1956, il publie dans Esprit en 1957 « La paix des némentchas », sur la “pacification”, et dans Vérité-Liberté en 1960 « Le grand refus », sur les déserteurs et les insoumis. Emprisonné aux Beaumettes en juin 61 pour ses activités de soutien au FLN, il ne sera libéré qu’un an plus tard, après les accords d’Evian. C’est justement le rapport entre l’activité de l’historien et celle de l’organisateur de réseaux, entre le théoricien de l’histoire universelle et le « transporteur » que nous avons voulu interroger. À l’intersection se dessine une drôle de figure de pédagogue : un militant pas tout à fait clandestin et un théoricien encore un peu isolé.
Les temps irréels
Authors: Sullo Pierluigi , Papathéodorou Aris 
Published: October 2014

Résumé Le 30 septembre dernier, à Prague, plusieurs milliers de manifestants venus de divers pays d’Europe parvenaient à bloquer le sommet annuel du Fonds monétaire international et de la Banque mondiale, malgré la brutalité de la police tchèque et dans l’indifférence de la presse. On peut évidemment trouver à redire au mouvement de résistance à la mondialisation libérale : la généralité de son objet ; la manière dont il détourne les énergies militantes dont manquent cruellement, en ce moment, les mouvements locaux (...)
« choisis, contrôlés, placés »
Authors: Morice Alain 
Published: October 2014

Résumé	Le savoir d’Alain Morice, chercheur au CNRS, est une alternative précieuse à celui des experts. Il nous livre ici une critique du nouveau discours européen de l’immigration « utile », celui des caisses de retraite et des gestionnaires de main-d’oeuvre, dont il montre que la modernité n’est que relative. Car, autant qu’un texte de police, la bonne vieille ordonnance du 2 novembre 1945 est un plan d’emploi : depuis toujours, un bon immigré est un immigré au travail. En creux, cette critique ouvre aussi à quelque chose comme une autre approche de l’immigration : il faudrait penser les mobilités au ras du sol, telles qu’elles se pratiquent réellement et à la première personne, avec les problèmes qu’elles nous posent. Liquider la question « comment les employer ? », c’est en libérer une autre, bien plus intéressante : « Pourquoi nous déplaçons-nous ? »
Être ensemble en restant singuliers
Authors: Triau Christophe 
Published: October 2014

Résumé	Depuis quelques années, Frédéric Fisbach s’est imposé comme l’un des metteurs en scène les plus intéressants du théâtre français ; la saison dernière a particulièrement été marquée par ses deux derniers spectacles, Tokyo notes, d’Horiza Hirata, et Forever Valley, « opéra de chambre » de Gérard Pesson et Marie Redonnet. Il montera ce printemps Bérénice, en collaboration avec le chorégraphe Bernardo Montet.
Dans l'image
Authors: Mangeot Philippe 
Published: October 2014

Résumé Le 8 janvier, dans le cadre d’une série intitulée « Journaux intimes », Canal+ diffuse Ceci est une pipe de Pierre Trividic et Patrick Mario Bernard (avec la collaboration de Xavier Brillat). Une réflexion sur les pouvoirs de l’image, sur la représentation des corps et de la sexualité, sur la fabrication d’un film, sur l’intime et le public, sur la confusion des genres.
Vers une approche interactionnelle en didactique des langues et une extension du domaine de la tâche – Les atouts du web 2.0
Authors: Ollivier Christian 
Published: October 2014

Cette contribution développe le concept d'approche interactionnelle et celui de tâche ancrée dans la vie réelle réalisable sur des sites participatifs du web 2.0. En reprenant des résultats de recherche publiés ces dernières années, nous mettons en lumière le fort potentiel de ce type de tâche comme solution aux diverses limites des cours de langues, que plusieurs études ont fait ressortir depuis les années 70, notamment le problème de bi-focalisation, l'apprenant se concentrant souvent plus sur l'apprentissage de la langue que sur la communication / l'action en tant que telle.Cette partie théorique est complétée par des exemples de tâches de la vie réelle permettant aux apprenants d'utiliser la langue au sein d'interactions sociales dépassant celles du groupe enseignant-apprenants.
Anti-GITR Agonist Therapy Intrinsically Enhances CD8 T Cell Responses to Chronic Lymphocytic Choriomeningitis Virus (LCMV), Thereby Circumventing LCMV-Induced Downregulation of Costimulatory GITR Ligand on APC
Authors: Clouthier Derek L. , Zhou Angela C. , Watts Tania H. 
Published: October 2014

Abstract
The costimulatory TNFR family member GITR can provide important survival signals for CD8 T cells. However, little is known about the regulation of this pathway during a chronic infection. In this study, we show that GITR ligand (GITRL) is maximally induced on APCs at day 2 post–lymphocytic choriomeningitis virus (LCMV) clone 13 infection, but is downregulated to below baseline levels by day 8 postinfection (p.i.), and remains so at the chronic stage of infection. At its peak, GITRL expression is highest on macrophages, with lower expression on conventional and plasmacytoid dendritic cells. GITR expression was highest on T regulatory cells but was also detected on Th1 and LCMV-specific CD8 T cells at day 8 p.i. and was maintained at low, but above baseline levels at the chronic stage of LCMV infection. As GITRL was limiting at the chronic stage of infection, we investigated the potential of therapeutic stimulation of GITR at this stage using agonistic anti-GITR Ab. Anti-GITR treatment at day 21 p.i. increased the frequency and number of LCMV-specific CD8 T cells, resulting in increased in vivo CTL activity and a concomitant decrease in viral load, despite the persistence of PD-1 expression. These effects of anti-GITR were CD8 T cell intrinsic, with no detectable effects on Th1 or T regulatory cells. In contrast to other TNFR agonists, such as anti–4-1BB, which can cause immune pathology, a single therapeutic dose of anti-GITR did not induce splenomegaly or increase serum alanine transaminase. These studies identify GITR as a promising therapeutic target for chronic infection.
Pristane-Induced Granulocyte Recruitment Promotes Phenotypic Conversion of Macrophages and Protects against Diffuse Pulmonary Hemorrhage in Mac-1 Deficiency
Authors: Shi Yiqin , Tsuboi Naotake , Furuhashi Kazuhiro , Du Qiuna , Horinouchi Asuka , Maeda Kayaho , Kosugi Tomoki , Matsuo Seiichi , Maruyama Shoichi 
Published: October 2014

Abstract
Diffuse pulmonary hemorrhage (DPH) is an uncommon but critical complication of systemic lupus erythematosus. Peritoneal administration of 2,6,10,14-tetramethylpentadecane (pristane) can recapitulate a lupus-like syndrome in mice, which can develop into DPH within a few weeks, especially in C57BL/6 mice. Mac-1 (CD11b/CD18), a leukocyte adhesion molecule, is known to play a role in inflammation by regulating migration of leukocytes into injured tissue. In this study, we aimed to clarify the role of Mac-1 in pristane-induced DPH, using Mac-1−/− and wild-type (WT) mice on a C57BL/6 background. After pristane injection, Mac-1−/− mice showed reduced prevalence of DPH and attenuated peritonitis compared with WT mice. Analysis of the peritoneal lavage on days 5 and 10 after pristane treatment revealed increased numbers of eosinophils and alternatively activated macrophages, but decreased numbers of neutrophils and classically activated macrophages in Mac-1−/− mice compared with WT. Enhanced production of IL-4 and IL-13, both key mediators of macrophage polarization toward the mannose receptor+ (MMR+) phenotype, was observed in the peritoneal cavity of Mac-1−/− mice. Depletion of neutrophils and eosinophils or adoptive transfer of classically activated macrophages resulted in the exacerbation of pristane-mediated DPH in both WT and Mac-1−/− mice. Moreover, peritoneal transfer of F4/80highMMR+ alternatively activated macrophages successfully reduced the prevalence of DPH in WT mice. Collectively, Mac-1 promoted acute inflammatory responses in the peritoneal cavity and the lungs by downregulating granulocyte migration and subsequent phenotypic conversion of macrophages in a pristane-induced systemic lupus erythematosus model.
Ein nanoskaliges Supramolekül jenseits der Fulleren‐Topologie
Authors: Dielmann Fabian , Heindl Claudia , Hastreiter Florian , Peresypkina Eugenia V. , Virovets Alexander V. , Gschwind Ruth M. , Scheer Manfred 
Published: October 2014

AbstractDie Reaktion von [CpBnFe(η5‐P5)] (1) (CpBn=η5‐C5(CH2Ph)5) mit CuI ergibt selektiv das neue sphärische Supramolekül (CH2Cl2)3.4@[(CpBnFeP5)12{CuI}54(MeCN)1.46] (2), welches eine Verknüpfung von Gerüstatomen jenseits der Fulleren‐Topologie zeigt. Sein ausgedehntes CuI‐Gerüst weist einen Außendurchmesser von 3.7 nm auf – eine Größe, die bisher nicht erreicht wurde, wenn fünffach symmetrische Bausteine hierfür verwendet wurden. Weiterhin weist 2 eine bemerkenswerte Löslichkeit in CH2Cl2 auf, und NMR‐Experimente belegen, dass das Gerüst des Supramoleküls in Lösung intakt bleibt. Zusätzlich wurde das neue 2D‐Polymer [{CpBnFe(η5‐P5)}2{Cu6(μ‐I)2(μ3‐I)4}]n (3) mit einem ungewöhnlichen Strukturmotiv isoliert. Seine Bildung kann durch einen großen Überschuss an CuI in der Reaktion mit 1 verhindert werden.
One‐Pot Transformation of Simple Furans into 4‐Hydroxy‐2‐cyclopentenones in Water
Authors: Kalaitzakis Dimitris , Triantafyllakis Myron , Alexopoulou Ioanna , Sofiadis Manolis , Vassilikogiannakis Georgios 
Published: October 2014

AbstractA highly efficient one‐pot transformation of readily accessible furans into 4‐hydroxy‐2‐cyclopentenones in H2O, using singlet oxygen as oxidant, has been developed.
An Ylide Transformation of Rhodium(I) Carbene: Enantioselective Three‐Component Reaction through Trapping of Rhodium(I)‐Associated Ammonium Ylides by β‐Nitroacrylates
Authors: Ma Xiaochu , Jiang Jun , Lv Siying , Yao Wenfeng , Yang Yang , Liu Shunying , Xia Fei , Hu Wenhao 
Published: October 2014

AbstractThe chiral RhI–diene‐catalyzed asymmetric three‐component reaction of aryldiazoacetates, aromatic amines, and β‐nitroacrylates was achieved to obtain γ‐nitro‐α‐amino‐succinates in good yields and with high diastereo‐ and enantioselectivity. This reaction is proposed to proceed through the enantioselective trapping of RhI‐associated ammonium ylides by nitroacrylates. This new transformation represents the first example of RhI‐carbene‐induced ylide transformation.