bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphorylations of Sds23/Psp1/Moc1 by stress‐activated kinase and cAMP‐dependent kinase are essential for regulating cell viability in prolonged stationary phase
Authors: Jang Young‐Joo , Won Misun , Yoo Hyang‐Sook 
Published: May 2013

AbstractUnder nutritional deprivation caused by prolonged culture, actively growing cells prepare to enter stationary phase. We showed here that Sds23/Psp1/Moc1 was phosphorylated by both cAMP‐dependent kinase and stress‐activated MAP kinase Sty1 upon entry into stationary phase. Overexpression of the phosphorylation‐defective mutant Sds23/Psp1/Moc1 induced cell death in prolonged culture and blocked re‐entry into the cell division cycle. These phosphorylations are likely to be required for cell survival during stationary phase and for binding of Ufd2, a Schizosaccharomyces pombe homologue of multi‐ubiquitin chain assembly factor E4. Deletion of the Ufd2 gene and overexpression of Sds23/Psp1/Moc1 increased cell viability in prolonged stationary phase. These results suggested that Ufd2 induces cell death in prolonged nutrient deprivation, that Sds23/Psp1/Moc1 may be a target protein of the ubiquitin‐fusion degradation pathway for regulation of cell viability under this stress condition, and that Sty1 and PKA activity in stationary phase is essential for interaction between Sds23/Psp1/Moc1 and Ufd2. Copyright © 2013 John Wiley & Sons, Ltd.
Extended Lymphadenectomy in Esophageal Cancer is Crucial
Authors: Tong Daniel , Law Simon 
Published: May 2013

AbstractSurgery with lymphadenectomy remains the mainstay of treatment for esophageal cancer. The optimal extent of nodal dissection is controversial. Evidence is accumulating, however, that could demonstrate the benefits of extended lymphadenectomy, which include more accurate disease staging, better locoregional disease control, and improved survival. Except in very early disease where nodal metastases are rare, extended lymphadenectomy is indicated. Data from a randomized controlled trial comparing transhiatal and transthoracic resection have shown better survival in patients with limited nodal burden. Other investigations on en bloc resection, three‐field lymphadenectomy, and large‐scale international collaborative studies have all provided evidence for the more extensive approach to enhance cure for esophageal cancer. The more extended surgery does lead to potentially higher morbidity rates, and thus surgeons should be versatile in applying such techniques in carefully selected patients, so that postoperative survival and quality of life of patients are not compromised. The challenge in the future is how to tailor surgical strategies for individual patients in order to achieve the best outcome.
Farmer innovation diffusion via network building: a case of winter greenhouse diffusion in China
Authors: Wu Bin , Zhang Liyan 
Published: May 2013

Abstract
Farmer innovation diffusion (FID) in the developing world is not simply the adoption of an innovation made by farmers, but a process of communication and cooperation between farmers, governments, and other stakeholders. While increasing attention has been paid to farmer innovation, little is known about how farmers’ innovations are successfully diffused. To fill this gap, this paper aims to address the following questions: What conditions are necessary for farmers to participate in FID? How is a collaborative network built up between farmers and stakeholders for this purpose? And what roles can government play? The above questions are addressed through analysis of the diffusion of winter greenhouse technology in China. A framework for analyzing a FID system is developed, and the conclusion is drawn that building mutual trust and collaborative networks is crucial for the success of FID. Furthermore, this network building can be broken down into various levels with different scales, speeds and consequences for FID: informal networks among farmers themselves, farmer-led networks, and government-facilitated networks. The success of government intervention depends upon building and enhancing the collaborative networks in which farmer leadership is crucial.
Genetic Counseling Services and Development of Training Programs in Malaysia
Authors: Lee Juliana Mei‐Har , Thong Meow‐Keong 
Published: May 2013

AbstractGenetic counseling service is urgently required in developing countries. In Malaysia, the first medical genetic service was introduced in 1994 at one of the main teaching hospitals in Kuala Lumpur. Two decades later, the medical genetic services have improved with the availability of genetic counseling, genetic testing and diagnosis, for both paediatric conditions and adult‐onset inherited conditions, at four main centers of medical genetic services in Malaysia. Prenatal diagnosis services and assisted reproductive technologies are available at tertiary centres and private medical facilities. Positive developments include governmental recognition of Clinical Genetics as a subspecialty, increased funding for genetics services, development of medical ethics guidelines, and establishment of support groups. However, the country lacked qualified genetic counselors. Proposals were presented to policy‐makers to develop genetic counseling courses. Challenges encountered included limited resources and public awareness, ethical dilemmas such as religious and social issues and inadequate genetic health professionals especially genetic counselors.
Effects of dietary energy density and digestible protein:energy ratio onde novolipid synthesis from dietary protein in gilthead sea bream (Sparus aurata) quantified with stable isotopes
Authors: Ekmann Kim S. , Dalsgaard Johanne , Holm Jørgen , Campbell Patrick J. , Skov Peter V. 
Published: May 2013

The effects of varying dietary digestible protein (DP) and digestible energy (DE) content on performance, nutrient retention efficiency and thede novolipogenesis of DP origin were examined in triplicate groups of gilthead sea bream (Sparus aurata), fed nine extruded experimental diets. In order to trace the metabolic fate of dietary protein, 1·8 % fishmeal was replaced with isotope-labelled whole protein (>98 %13C). The experiment was divided into a growth period lasting 89 d, growing fish from approximately 140 to 350 g, followed by a 3 d period feeding isotope-enriched diets. Isotope ratio MS was applied to quantify the13C enrichment of whole-body lipid from dietary DP. Between 18·6 and 22·4 % of the carbon derived from protein was recovered in the lipid fraction of the fish, and between 21·6 and 30·3 % of the total lipid deposited could be attributed to dietary protein. DP retention was significantly improved by reductions in dietary DP:DE ratio, while the opposite was true for apparent digestible lipid retention. Both overall DE retention and whole-body proximate composition of whole fish were largely unaffected by dietary treatments, while feed conversion ratios were significantly improved with increasing dietary energy density. The present study suggests that gilthead sea bream efficiently utilises dietary nutrients over a wide range of DP:DE ratios and energy densities. In addition, they appear to endeavour a certain body energy status rather than maximising growth, which in the present trial was apparent from inherently highde novolipogenesis originating from DP.
CITIZENS FOR EISENHOWER AND THE REPUBLICAN PARTY, 1951–1965
Authors: MASON ROBERT 
Published: May 2013

ABSTRACTFounded in support of Dwight D. Eisenhower's 1952 presidential candidacy, Citizens for Eisenhower took on an ambitious mission to revitalize the Republican party by expanding its activist ranks and by supporting the moderation of its conservative policy agenda. The organization proved unable to sustain the impressive momentum that it achieved during the 1952 campaign, however, instead helping to fuel factional opposition that informed the intraparty upsurge of conservatism during the 1950s and afterwards. The Eisenhower administration's efforts to encourage Citizens activists to join the party were flawed, and existing Republican activists often viewed such newcomers with hostility. More significantly, despite recruitment initiatives, in most cases activism in support of Eisenhower did not translate into enthusiasm for the party cause. The history of Citizens for Eisenhower therefore demonstrates the seriousness of Eisenhower's interests as president in boosting the Republican party's fortunes, but also the shortcomings of ‘amateur’ political activity in support of the party cause. It also sheds light on goals and activities of this era's moderate Republicans, together with their role in fostering the conservative resurgence that characterized the post-Eisenhower Republican party.
ROYALISM, PRINT, AND THE CLERGY IN BRITAIN, 1639–1640 AND 1642
Authors: BOWEN LLOYD 
Published: May 2013

ABSTRACTCharles I and his clerical supporters are often said to have been wary of print and public discussion, only entering the public sphere reluctantly and to comparatively little effect during the political crisis of 1642. This article challenges such views by focusing on the neglected role of official forms of print such as proclamations, declarations, and state prayers and their promulgation in the nation's churches. It traces the ways in which the king utilized the network of parish clergy to broadcast his message and mobilize support during the Scottish crisis of 1639–40 and again in the ‘paper war’ of 1642. The article argues that traditional forms of printed address retained their potency and influence despite the proliferation of polemical pamphlets and newsbooks. The significance of these mobilizations is demonstrated by the profound disquiet they caused among the king's Covenanter and parliamentarian opponents as well as the ‘good effects’ they had in generating support for the royalist cause.
The Redistributive Impact of ‘Old’ and ‘New’ Social Spending
Authors: VAALAVUO MARIA 
Published: May 2013

AbstractThe welfare state literature has recently identified a shift from the protection against traditional risks to social investment. In this new future-oriented and activation-based social policy, the focus is on the redistribution of opportunities instead of income. Even if vertical redistribution from the rich to poor may be only one rationale of social action, it should not be overlooked when directing social policy from insurance to investment. This article has two objectives: first, it investigates how real this shift is in macro-economic terms, and, secondly, whether the increased focus on new social risks and social investment has possibly changed welfare states’ commitment to redistribute from the rich to poor. I compare the distribution of benefits from ‘old’ spending categories (such as retirement or unemployment) with those from ‘new’ ones (such as having care responsibilities). Analysing six European countries representing different welfare state regimes, I find no evidence that new social spending would mean necessarily renouncing egalitarian ambitions. On the contrary, in all countries the distribution of new spending is more equal or pro-poor than the spending on old social risks. Different households benefit in distinct ways: the elderly benefiting the most from traditional spending (with the exception of elderly care that is categorised here as ‘new’ social spending) and families with children and single parents from new spending.
Application of picosecond terawatt laser pulses for fast ignition of fusion
Authors: Hora H. , Miley G.H. , Ghoranneviss M. , Salar Elahi A. 
Published: May 2013

AbstractIn this research, we presented the application of picosecond terawatt laser pulses for ultrahigh acceleration of plasma blocks for fast ignition of fusion. Ultrahigh acceleration of plasma blocks after irradiation of picosecond laser pulses of around terawatt power in the range of 1020 cm/s2was discovered by Sauerbrey (1996) as measured by Doppler effect where the laser intensity was up to about 1018W/cm2. This is several orders of magnitude higher than acceleration by irradiation based on thermal interaction of lasers has produced. This ultrahigh acceleration resulted from hydrodynamic computations at plane target interaction in 1978 at comparable conditions where the interaction was dominated by the nonlinear (generalized ponderomotive) forces where the laser energy was instantly converted into plasma motion in contrast to slow and delayed thermal collision processes. After clarifying this basic result, the application of the plasma blocks for side-on ignition of solid density or modestly compressed fusion fuel following the theory of Chu (1971) is updated in view of later discovered plasma properties and the ignition of deuterium tritium and of proton-11B appeared possible for a dozen of PW-PS laser pulses if an extremely high contrast ratio avoided relativistic self-focusing. A re-evaluation of more recent experiment confirms the acceleration by the nonlinear force, and the generation of the fusion flame with properties of Rankine-Hugoniot shocks is reported.
A regressor-free adaptive controller for robot manipulators without Slotine and Li's modification
Authors: Kai Chen-Yu , Huang An-Chyau 
Published: May 2013

SUMMARYSimilar to the traditional adaptive strategies for robot manipulators, the regressor-free adaptive controller design also requires applying Slotine and Li's modification to avoid the feedback of joint accelerations. In this paper, a simple method is proposed to construct a regressor-free adaptive controller for robot manipulators without Slotine and Li's modification. In the new design, the joint acceleration vector is lumped into an unknown time-varying function and the function approximation technique is utilized to cover its effect; therefore, its implementation is free from joint acceleration feedback. The closed-loop stability and boundedness of internal signals are justified by the Lyapunov-like technique. Both simulation and experimental results for a two-link robot are presented to show the effectiveness of the proposed design.
A review on agent-based technology for traffic and transportation
Authors: Bazzan Ana L. C. , Klügl Franziska 
Published: May 2013

AbstractIn the last few years, the number of papers devoted to applications of agent-based technologies to traffic and transportation engineering has grown enormously. Thus, it seems to be the appropriate time to shed light over the achievements of the last decade, on the questions that have been successfully addressed, as well as on remaining challenging issues. In the present paper, we review the literature related to the areas of agent-based traffic modelling and simulation, and agent-based traffic control and management. Later we discuss and summarize the main achievements and the challenges.
A survey of commonly used ensemble-based classification techniques
Authors: Jurek Anna , Bi Yaxin , Wu Shengli , Nugent Chris 
Published: May 2013

AbstractThe combination of multiple classifiers, commonly referred to as a classifier ensemble, has previously demonstrated the ability to improve classification accuracy in many application domains. As a result this area has attracted significant amount of research in recent years. The aim of this paper has therefore been to provide a state of the art review of the most well-known ensemble techniques with the main focus on bagging, boosting and stacking and to trace the recent attempts, which have been made to improve their performance. Within this paper, we present and compare an updated view on the different modifications of these techniques, which have specifically aimed to address some of the drawbacks of these methods namely the low diversity problem in bagging or the over-fitting problem in boosting. In addition, we provide a review of different ensemble selection methods based on both static and dynamic approaches. We present some new directions which have been adopted in the area of classifier ensembles from a range of recently published studies. In order to provide a deeper insight into the ensembles themselves a range of existing theoretical studies have been reviewed in the paper.
A Hobbesian Approach to Cruelty and the Rules of War
Authors: MAY LARRY 
Published: May 2013

AbstractContrary to the way Hobbes has been interpreted for centuries, I will argue that Hobbes laid the groundwork for contemporary international law and for a distinctly moral approach to the rules of war. The paper has the following structure. First, I will explain the role that the laws of nature play in Hobbes's understanding of the state of war. Second, I will explain Hobbes's views of self-preservation and inflicting cruelty. Third, I reconstruct Hobbes's important insight that rationality governs all human affairs, even those concerning war. Fourth, I explicate the idea of cruelty moving from what Hobbes says to a plausible Hobbesian position. Fifth, I address recent philosophical writing on how best to understand the rules of war. Sixth, I then turn to legal discussions of cruelty's place in debates about the laws of war, showing how my Hobbesian approach can ground these laws.
Beyond advanced stages in high-level spoken L2 French
Authors: LUNDELL FANNY FORSBERG , BARTNING INGE , ENGEL HUGUES , GUDMUNDSON ANNA , HANCOCK VICTORINE , LINDQVIST CHRISTINA 
Published: May 2013

ABSTRACTThe aim of this study is twofold: first, to find evidence for additional advanced stages in L2 French. The continuum of Bartning and Schlyter (2004) is taken as a point of departure. It is hypothesized that a number of linguistic criteria will account for high-level proficiency. It was earlier found that besides morpho-syntax, formulaic sequences and information structure are interesting phenomena for highly proficient learners (Bartning, Forsberg and Hancock, 2009). Three more measures are now added, i.e. perceived nativelikeness, lexical richness and fluency.The second aim of this study is to contribute to the debate on the possibility of nativelike attainment. The study shows that several measures are prone to characterise nativelike performance in highly proficient users among whom some attain nativelikeness.
Effect of Hydroxocobalamin on Surface Oximetry in Nonexposed Humans
Authors: Cashin Brian V. , Matlock Aaron G. , Kang Chris , Reynolds Penny S. , Wills Brandon K. 
Published: May 2013

AbstractIntroductionThe newer cyanide antidote, hydroxocobalamin, due to its pigmentation, has been found to cause interferences in some laboratory assays. Co-oximetry may also be affected by hydroxocobalamin, leading to false elevations in hemoglobin concentration, methemoglobin, carboxyhemoglobin, and false decreases in oxyhemoglobin. The Masimo Radical-7 is a medical device that performs noninvasive oximetry and estimates hemoglobin (Hb) concentration and percent carboxyhemoglobin (COHb), methemoglobin (MetHb), and oxyhemoglobin saturation (O2Hb).Study ObjectivesThe study sought to determine the effect of hydroxocobalamin on noninvasive measurement of hemoglobin indices using the Masimo Radical-7 monitor.MethodsSeven asymptomatic volunteers who were unexposed to cyanide had baseline heart rate (HR), blood pressure (BP), and oximeter measurements recorded followed by an infusion of five grams of hydroxocobalamin over 15 minutes. The above parameters were subsequently recorded at: 5, 10, 15, 30 and 60 minutes post infusion. Data were analyzed by calculating the area under the curve (AUC) for each variable and comparing the results to expected values by pairedttests. Expected AUC values were calculated by extrapolating baseline values across the entire time period.ResultsThe mean differences from baseline values with 95% confidence intervals andttests of mean difference were: SBP: 11 mm Hg (95% CI, 0-22;P= .051); HR: -9 (95% CI, -15 to -3;P= .01); Hb: -0.1 (95% CI, -0.7 to 0.4;P= .57); O2Hb: 0 g/dL (95% CI, -1 to 1;P= .41); COHb: -1 (95% CI, -3 to 1;P= .25); MetHb: -0.2 (95% CI, -0.3 to 0;P= .03).DiscussionAfter infusion of hydroxocobalamin there was a significant elevation of systolic blood pressure and decrease in heart rate. There were no significant differences in Hb, O2Hb, and COHb. Although percent methemoglobin concentrations were statistically lower, the authors feel this difference is of trivial clinical significance.ConclusionThe administration of hydroxocobalamin does not significantly impact noninvasive oximetry.CashinB,MatlockA,KangC,ReynoldsP,WillsB.Effect of hydroxocobalamin on surface oximetry in nonexposed humans.Prehosp Disaster Med.2013;28(4):1-3.
Quantitative Evaluation of Spinodal Decomposition in Fe-Cr by Atom Probe Tomography and Radial Distribution Function Analysis
Authors: Zhou Jing , Odqvist Joakim , Thuvander Mattias , Hedström Peter 
Published: May 2013

AbstractNanostructure evolution during low temperature aging of three binary Fe-Cr alloys has been investigated by atom probe tomography. A new method based on radial distribution function (RDF) analysis to quantify the composition wavelength and amplitude of spinodal decomposition is proposed. Wavelengths estimated from RDF have a power-law type evolution and are in reasonable agreement with wavelengths estimated using other more conventional methods. The main advantages of the proposed method are the following: (1) Selecting a box size to generate the frequency diagram, which is known to generate bias in the evaluation of amplitude, is avoided. (2) The determination of amplitude is systematic and utilizes the wavelength evaluated first to subsequently evaluate the amplitude. (3) The RDF is capable of representing very subtle decomposition, which is not possible using frequency diagrams, and thus a proposed theoretical treatment of the experimental RDF creates the possibility to determine amplitude at very early stages of spinodal decomposition.
Extravascular CX3CR1+Cells Extend Intravascular Dendritic Processes into Intact Central Nervous System Vessel Lumen
Authors: Barkauskas Deborah S. , Evans Teresa A. , Myers Jay , Petrosiute Agne , Silver Jerry , Huang Alex Y. 
Published: May 2013

AbstractWithin the central nervous system (CNS), antigen-presenting cells (APCs) play a critical role in orchestrating inflammatory responses where they present CNS-derived antigens to immune cells that are recruited from the circulation to the cerebrospinal fluid, parenchyma, and perivascular space. Available data indicate that APCs do so indirectly from outside of CNS vessels without direct access to luminal contents. Here, we applied high-resolution, dynamic intravital two-photon laser scanning microscopy to directly visualize extravascular CX3CR1+APC behavior deep within undisrupted CNS tissues in two distinct anatomical sites under three different inflammatory stimuli. Surprisingly, we observed that CNS-resident APCs dynamically extend their cellular processes across an intact vessel wall into the vascular lumen with preservation of vessel integrity. While only a small number of APCs displayed intravascular extensions in intact, noninflamed vessels in the brain and the spinal cord, the frequency of projections increased over days in an experimental autoimmune encephalomyelitis model, whereas the number of projections remained stable compared to baseline days after tissue injury such as CNS tumor infiltration and aseptic spinal cord trauma. Our observation of this unique behavior by parenchyma CX3CR1+cells in the CNS argues for further exploration into their functional role in antigen sampling and immune cell recruitment.