bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency‐domain optical coherence tomography assessment of unprotected left main coronary artery disease—a comparison with intravascular ultrasound
Authors: Fujino Yusuke , Bezerra Hiram G. , Attizzani Guilherme F. , Wang Wei , Yamamoto Hirosada , Chamié Daniel , Kanaya Tomoaki , Mehanna Emile , Tahara Satoko , Nakamura Sunao , Costa Marco A. 
Published: January 2013

ObjectivesTo investigate safety and feasibility of imaging unprotected left main (ULM) using frequency‐domain optical coherence tomography (FD‐OCT) compared with intravascular ultrasound (IVUS).BackgroundIVUS has been used to assess and guide percutaneous coronary intervention (PCI) of ULM disease. FD‐OCT offers 10‐fold higher axial resolution than IVUS and its high‐speed image acquisition obviates the need for proximal balloon occlusion.MethodsWe prospectively enrolled 35 consecutive patients with ULM disease. FD‐OCT and IVUS assessments were attempted pre‐ and post‐PCI and compared in regards to safety, ability to image the region of interest (ROI), number of pullbacks, volume of contrast and ability to detect malapposition, dissection, and thrombus.ResultsPatients were followed for 1 year when FD‐OCT imaging was repeated. FD‐OCT required more repeated pullbacks to image the ROI compared to IVUS. Mean lumen and stent areas were similar between FD‐OCT and IVUS (11.24 ± 2.66 vs. 10.85 ± 2.47 mm2, P = 0.13 and 10.44 ± 2.33 vs. 10.49 ± 2.32 mm2, P = 0.82, respectively), whereas imaged stent length was shorter with FD‐OCT. Malapposition areas and volumes were larger and more edge dissections were detected by FD‐OCT. There were no clinical adverse events and no complications associated with FD‐OCT at baseline and 1‐year follow‐up. All dissections were healed, whereas stent malapposition was still detected at follow‐up.ConclusionsFD‐OCT assessment of ULM is feasible and safe. Direct comparisons with IVUS reveal that FD‐OCT achieved imaging completeness less often, whereas it was more sensitive in detecting malapposition and edge dissections, and similar to IVUS in the assessment of lumen and stent dimensions. © 2013 Wiley Periodicals, Inc.
Head‐to‐head comparison of sirolimus‐eluting stent versus bare metal stent evaluation of the coronary endothelial dysfunction in the same patient presenting with multiple coronary artery lesions: The CREDENTIAL study
Authors: Mischie Alexandru Nicolae , Nazzaro Marco Stefano , Fiorilli Rosario , De Felice Francesco , Musto Carmine , Confessore Pierpaolo , Parma Antonio , Boschetti Carla , Violini Roberto 
Published: January 2013

ObjectivesTo assess the endothelial dysfunction (ED) after bare metal stents (BMS) and sirolimus eluting stents (SES) implantation in the same patient, overcoming the confounding role of individual variables.BackgroundSES reduce restenosis rate compared to BMS but causes more ED. ED is a potentially unsafe phenomenon, since it is the first step in the cascade of atherosclerosis. Studies showing more pronounced ED with drug eluting stents than BMS involved different series of patients, making the comparison difficult because endothelial function (EF) is responsive to many risk factors.Methodswe designed a prospective comparison of 6 months post‐deployment EF of SES versus BMS implanted in the same patient, but in different coronary segments. Forty‐eight lesions were randomly assigned on a 1:1 allocation using block sizing of 4 according to a computer‐generated sequence (SAS System, Version 9.1) basis to treatment with SES or BMS. The EF was evaluated by measuring vessel diameter variation in the stented segment, before and after selective intracoronary infusion of acetylcholine (iiAch).ResultsIn eligible patients, the relative magnitudes of major vasoconstriction were 2.6, 2.9, 4.6, and 3.1 at 5 mm proximal and 5, 10 and 20 mm distal to the stent edge. Overall, a 3.5‐fold major distal vasoconstriction after iiAch of SES vs. BMS was calculated.Conclusionsin the same patients, but treating different coronary segments, SES implantation induces a higher rate of vasoconstriction compared to BMS. The increased vasoconstriction after iiAch is an indicator of ED.© 2013 Wiley Periodicals, Inc.
Women treated with second‐generation zotarolimus‐eluting resolute stents and everolimus‐eluting xience V stents: insights from the gender‐stratified, randomized, controlled TWENTE trial
Authors: Tandjung Kenneth , Basalus Mounir W.Z. , Sen Hanim , Stoel Martin G. , van Houwelingen K. Gert , Louwerenburg J. (Hans) W. , de Man Frits H.A.F. , Linssen Gerard C.M. , Saïd Salah A.M. , Kleijne Miep A.W.J. , van der Palen Job , von Birgelen Clemens 
Published: January 2013

BackgroundWomen are underrepresented in clinical research, and few data are available from randomized head‐to‐head comparisons of second‐generation drug‐eluting stents (DES) in female patients. Aim of this study was to assess safety and efficacy of two second‐generation DES in women. In TWENTE—a prospective, randomized, comparative DES trial—“real‐world” patients were stratified for gender before randomization for Resolute or Xience V stents.MethodsTarget vessel failure (TVF; cardiac death, target vessel‐related myocardial infarction, and clinically indicated target vessel revascularization) after 1 year was the predefined endpoint.ResultsAmong 1,391 patients, 382 (27.5%) women were randomized to Resolute (n = 192) and Xience V (n = 190). Baseline and procedural characteristics were similar for females in both study arms, except for smaller vessel and stent diameters in Resolute‐treated lesions. After 1 year, TVF (8.9 vs. 8.4%; adjusted odds ratio [OR]: 0.95, 95% confidence interval [CI]: 0.41–2.20, P = 0.91) and a patient‐oriented composite endpoint (13.0 vs. 12.1%, P = 0.79) did not differ significantly between women in both arms. Women were older than men (P < 0.01) and had more often diabetes mellitus (26.4 vs. 19.8%, P = 0.01) and hypertension (63.6 vs. 52.5%, P < 0.01), but there was no significant gender difference in TVF (adjusted OR: 1.18, 95% CI: 0.73–1.92, P = 0.50).ConclusionsThis gender‐stratified TWENTE trial analysis resulted in no significant difference in safety and efficacy outcomes between Resolute‐ and Xience V‐treated females. © 2013 Wiley Periodicals, Inc.
Fixed‐Component Lanthanide‐Hybrid‐Fabricated Full‐Color Photoluminescent Films as Vapoluminescent Sensors
Authors: Xu Jun , Jia Lei , Jin Nengzhi , Ma Yufei , Liu Xiao , Wu Wenyu , Liu Weisheng , Tang Yu , Zhou Feng 
Published: January 2013

AbstractFull‐color lanthanide (Ln) photoluminescent materials have attracted considerable interest owing to their potential applications in display systems and lighting technologies. Herein, full‐color photoluminescent films have been designed and fabricated facilely with a fixed‐component Ln‐based (Ln=Tb and Eu) polymer hybrid doped with a proton‐sensitive amide‐type β‐diketonated photosensitizer, N‐(2‐pyridinyl)benzoylacetamide (HPBA). The tunable photoluminescence emissions of the films are achieved by changing the amounts of OH− in the hybrid rather than varying the relative concentrations of the lanthanide ions and photosensitizers, thus representing a new paradigm for full‐color displays. The emission color can also be finely tuned through the variation of the excitation wavelength, and white‐light emission can be achieved when the given film is excited at the visible region (405 nm). The photophysical properties and the mechanisms of the intra‐ and intermolecular energy transfer before and after deprotonation have been investigated in detail. Meanwhile, the films might find application as vapoluminescent sensors due to their good stability, sensitivity, reversibility, and quick response when triggered by a base–acid vapor.
Development and Experimental Operation of a Scrubbing System for CO2 Capture from Flue Gas Using Alkaline Solid Wastes
Authors: Bauer Markus , Hopf Norbert , Hofstetter Eugen , Peiffer Stefan 
Published: January 2013

AbstractEin innovativer, technischer Ansatz zur Reduzierung der CO2‐Emissionen wird vorgestellt, der alkalische Reststoffe zur mineralischen, langzeitstabilen Bindung des CO2 aus Rauchgasen nutzt. Mit dem entwickelten System zur alkalischen Rauchgaswäsche wurde an einem Kraftwerk ein umfassender Pilotbetrieb durchgeführt. Im praktischen Anlagenbetrieb konnte durch Optimierung der Prozessparameter Gasdurchsatz, CO2‐Partialdruck, Suspensionszirkulation und Feststoffgehalt eine CO2‐Bindung in der Größenordnung von 40 – 90 g kg–1 Reststoff und eine CO2‐Abscheideleistung bis zu 25 % erreicht werden. Wirtschaftlich ist das Verfahren vor allem dann, wenn die alkalischen Reststoffe und das CO2 am selben Ort anfallen und das carbonatisierte Material als Sekundärrohstoff weiterverwendet werden kann.
Particle Characterization within Highly Concentrated Dispersions – Fundamental Studies of a New Ultrasound Method
Authors: Weser Robert , Wessely Benno , Wöckel Sebastian , Hempel Ulrike 
Published: January 2013

AbstractEs wird eine neue Methode zur inlinefähigen Partikelcharakterisierung in hochkonzentrierten Dispersionen mittels Ultraschallrückstreuung vorgestellt, die sensitiv gegenüber der Partikelgröße und der Konzentration ist. Eine Analyse der Ultraschallrückstreusignale liefert neben der Schalldämpfung zusätzlich ein Maß für die Streuintensität. Die Messung kann ohne Probenahme und minimalinvasiv direkt im Prozess erfolgen.
Behavior of Bubbles in Bubble Columns with Vibration Exciter
Authors: Kniazev Boris , Keil Frerich J. 
Published: January 2013

AbstractBlasensäulen, die von unten mit einem Bodenschwinger im Frequenzbereich zwischen 40 und 400 Hz angeregt werden, zeigen deutlich verbesserte Stoffübergangsgeschwindigkeiten. Dies ist durch eine Verkleinerung der Blasen durch Spaltung und die damit verbundene Oberflächenvergrößerung bedingt. Hinzu kommt eine intensive Bewegung an der Blasengrenze. Anhand von Strömungssimulationen werden die beobachteten Phänomene erklärt. Der Energiebedarf für eine schwingende Blasensäule ist geringer als für einen begasten Rührkessel.
Carboxylic Acid (Bio)Isosteres in Drug Design
Authors: Ballatore Carlo , Huryn Donna M. , Smith Amos B. 
Published: January 2013

AbstractThe carboxylic acid functional group can be an important constituent of a pharmacophore, however, the presence of this moiety can also be responsible for significant drawbacks, including metabolic instability, toxicity, as well as limited passive diffusion across biological membranes. To avoid some of these shortcomings while retaining the desired attributes of the carboxylic acid moiety, medicinal chemists often investigate the use of carboxylic acid (bio)isosteres. The same type of strategy can also be effective for a variety other purposes, for example, to increase the selectivity of a biologically active compound or to create new intellectual property. Several carboxylic acid isosteres have been reported, however, the outcome of any isosteric replacement cannot be readily predicted as this strategy is generally found to be dependent upon the particular context (i.e., the characteristic properties of the drug and the drug–target). As a result, screening of a panel of isosteres is typically required. In this context, the discovery and development of novel carboxylic acid surrogates that could complement the existing palette of isosteres remains an important area of research. The goal of this Minireview is to provide an overview of the most commonly employed carboxylic acid (bio)isosteres and to present representative examples demonstrating the use and utility of each isostere in drug design.
Dose‐intensive chemotherapy including rituximab in Burkitt's leukemia or lymphoma regardless of human immunodeficiency virus infection status
Authors: Ribera Josep‐Maria , García Olga , Grande Carlos , Esteve Jordi , Oriol Albert , Bergua Juan , González‐Campos José , Vall‐llovera Ferran , Tormo Mar , Hernández‐Rivas Jesús‐Maria , García Daniel , Brunet Salut , Alonso Natalia , Barba Pere , Miralles Pilar , Llorente Andreu , Montesinos Pau , Moreno Maria‐José , Hernández‐Rivas Jose‐Ángel , Bernal Teresa 
Published: January 2013

AbstractBACKGROUND:The use of rituximab together with intensive chemotherapy in Burkitt's lymphoma or leukemia (BL) has been scarcely explored. This study prospectively evaluated and compared the outcome and toxicity of human immunodeficiency virus (HIV)‐positive and HIV‐negative patients with BL who were treated in an intensive immunochemotherapy‐based and age‐adapted trial.METHODS:A total of 118 adult patients (80 HIV‐negative and 38 HIV‐positive) aged 15 to 83 years were treated with 4 (nonbulky stages I‐II) or 6 (stages II bulky, III‐IV) cycles of intensive chemotherapy combined with rituximab. Reduction in chemotherapy doses and modification of the cycle schedules was performed in patients older than 55 years.RESULTS:The clinical characteristics of HIV‐positive patients were comparable with those who were HIV‐negative. Complete remission rates were 82% and 87%, respectively, and 9 patients died in induction, 9 died in remission, and 7 relapsed. After a median follow‐up of 2.5 years, nonsignificant differences were observed in the 4‐year disease‐free survival and overall survival (OS) probabilities (77% and 63% for HIV‐positive and 80% and 78% for HIV‐negative patients, respectively). Young HIV‐infected patients presented higher incidences of grade 3 or 4 mucositis and severe infectious episodes. Poor general status and bone marrow involvement, but not advanced age, were associated with a shorter OS, allowing the definition of 3 prognostic groups, with the OS ranging from 50% to 92%.CONCLUSIONS:Age‐adapted intensive immunochemotherapy is highly effective in both HIV‐negative and HIV‐positive patients, with a higher toxicity in the latter group. Poor general status and bone marrow involvement had a negative impact on survival. Cancer 2013. © 2013 American Cancer Society.
Increased survival associated with surgery and radiation therapy in metastatic gastric cancer
Authors: Shridhar Ravi , Almhanna Khaldoun , Hoffe Sarah E. , Fulp William , Weber Jill , Chuong Michael D. , Meredith Kenneth L. 
Published: January 2013

AbstractBACKGROUND:Patients with metastatic gastric cancer have poor survival. The purpose of this study was to compare outcomes of metastatic gastric cancer patients stratified by surgery and radiation therapy.METHODS:The Surveillance, Epidemiology, and End Results (SEER) database was accessed to identify patients with AJCC M1 stage IV gastric cancer (based on the American Joint Committee on Cancer Cancer Staging Manual, 6th edition) between 2004 thru 2008. Patients were divided into 4 groups: group 1, no surgery or radiation; group 2, radiation alone; group 3, surgery alone; group 4, surgery and radiation. Survival analysis was determined by Kaplan‐Meier and log‐rank analysis. Multivariate analysis (MVA) was analyzed by the Cox proportional hazard ratio model.RESULTS:A total of 5072 patients were identified. Surgery and/or radiation were associated with a survival benefit. Median and 2‐year survival for groups 1, 2, 3, and 4 was 7 months and 8.2%, 8 months and 8.9%, 10 months and 18.2%, and 16 months and 31.7%, respectively (P < .00001). MVA for all patients revealed that surgery and radiation were associated with decreased mortality whereas T‐stage, N‐stage, age, signet ring histology, and peritoneal metastases were associated with increased mortality. In patients treated with surgery, MVA showed that radiation was associated with decreased mortality, whereas T‐stage, N‐stage, age, removal of < 15 lymph nodes, signet ring histology, and peritoneal metastases was associated with increased mortality. Age was the only prognostic factor in patients who did not undergo surgery.CONCLUSIONS:Surgery and radiation are associated with increased survival in a subset of patients with metastatic gastric cancer. Prospective trials will be needed to address the role and sequence of surgery and radiation in metastatic gastric cancer. Cancer 2013. © 2013 American Cancer Society.
Synthesis and Characterization of Polynuclear Oxidobismuth Sulfonates
Authors: Miersch Linda , Rüffer Tobias , Schaarschmidt Dieter , Lang Heinrich , Troff Ralf W. , Schalley Christoph A. , Mehring Michael 
Published: January 2013

AbstractThe hydrolysis of [Bi6O4(OH)4(NO3)6]·H2O (1) in the presence of sodium alkylsulfonates gave the oxidobismuth sulfonates [{Bi38O45(C4H7SO3)8(NO3)14(dmso)19.5(H2O)2}][{Bi38O45(C4H7SO3)10(NO3)16(dmso)16(H2O)2}]·3H2O·3dmso (2, dmso = dimethyl sulfoxide), [Bi38O45(C6H13SO3)14(NO3)10(dmso)28] (3), and [Bi38O45(C8H17SO3)16(NO3)8(dmso)12] (4) upon crystallization from dmso. Compound 2 is the first example of a nanoscaled oxidobismuth cluster that is composed of both an anionic (charge 2–) and a cationic (charge 2+) fragment in the solid state. The clusters were characterized by elemental analysis, ESI mass spectrometry, IR and NMR spectroscopy, as well as thermal analysis. Crystals obtained for 2 were suitable for single‐crystal structure analysis.
Diversely Substituted Triazolo[1,5‐a][1,4]benzodiazepinones: A Post‐Ugi Copper‐Catalyzed Tandem Azide–Alkyne Cycloaddition/Ullmann C–N Coupling Approach
Authors: Vachhani Dipak D. , Kumar Amit , Modha Sachin G. , Sharma Sunil K. , Parmar Virinder S. , Van der Eycken Erik V. 
Published: January 2013

AbstractA diversity‐oriented approach comprising an Ugi 4‐component reaction and a copper‐catalyzed tandem azide–alkyne cycloaddition/Ullmann C–N coupling is elaborated. The methodology is compatible with various functional groups and allows the construction of triazolo[1,5‐a][1,4]benzodiazepinones in good yields.
Fabrication and Photovoltaic Properties of Silicon Solar Cells with Different Diameters and Heights of Nanopillars
Authors: Liu Jing , Zhang Xinshuai , Ashmkhan Marina , Dong Gangqiang , Liao Yuanxun , Wang Bo , Zhang Tianchong , Yi Futing 
Published: January 2013

AbstractSilicon nanopillars with average diameters from 200 to 900 nm and heights from 0.5 to 3 μm have been successfully fabricated by cesium chloride (CsCl) self‐assembly lithography and dry etching as antireflection layer for solar cells. The antireflection and photovoltaic characteristics for the structures of silicon nanopillars have been researched and show that the reflectivity, photovoltaic conversion efficiency (PCE), and external quantum efficiency (EQE) are greatly influenced by the average diameter and height of nanopillars. The nanopillars with small diameters and large heights can supress reflection, but have less‐favorable photovoltic properties because of greater surface recombination and a greater number of lattice defects. The lowest reflectivity was achieved for silicon nanopillars of 200 nm average diameter and 1.5 μm height, for which the reflectivity was below 5 % between the wavelengths of 400 and 1000 nm, and the solar cell with silicon nanopillars of 600 nm average diameter and 1.5 μm height exhibited the best solar cell performance with a PCE of 14.83 %, a short‐circuit current density (Jsc) of 36.89 mA cm−2, and an open‐circuit voltage (Voc) of 542 mV.
Timing of hepatectomy in resectable synchronous colorectal liver metastases (SCRLM): Simultaneous or delayed?
Authors: Yin Zi , Liu Chao , Chen Yajin , Bai Yu , Shang Changzhen , Yin Rongyan , Yin Dong , Wang Jie 
Published: January 2013

Abstract

The optimal surgical strategy for treatment of patients with synchronous colorectal liver metastases (SCLRM) remains controversial. We conducted a systematic review and meta-analysis of all observational studies to define the safety and efficacy of simultaneous versus delayed resection of the colon and liver. A search for all major databases and relevant journals from inception to April 2012 without restriction on languages or regions was performed. Outcome measures were the primary parameters of postoperative survival, complication, and mortality, as well as other parameters of blood loss, operative time, and length of hospitalization. The test of heterogeneity was performed with the

Q

statistic. A total of 2,880 patients were included in the meta-analysis. Long-term oncological pooled estimates of overall survival (hazard ratio [HR]: 0.96; 95% confidence interval [CI]: 0.81-1.14;

P

= 0.64;

I

2

= 0) and recurrence-free survival (HR: 1.04; 95% CI: 0.76-1.43;

P

= 0.79;

I

2

= 53%) all showed similar outcomes for both simultaneous and delayed resections. A lower incidence of postoperative complication was attributed to the simultaneous group as opposed to that in the delayed group (modified relative ratio [RR] = 0.77; 95% CI: 0.67-0.89;

P

= 0.0002;

I

2

= 10%), whereas in terms of mortality within the postoperative 60 days no statistical difference was detected (RR = 1.12; 95% CI: 0.61-2.08;

P

= 0.71;

I

2

= 32%). Finally, selection criteria were recommended for SCRLM patients suitable for a simultaneous resection.

Conclusion

: Simultaneous resection is as efficient as a delayed procedure for long-term survival. There is evidence that in SCRLM patients simultaneous resection is an acceptable and safe option with carefully selected conditions. Due to the inherent limitations of the present study, future randomized controlled trials will be useful to confirm this conclusion.
Selective hepatic insulin resistance in a murine model heterozygous for a mitochondrial trifunctional protein defect
Authors: Rector Scott R. , Morris Matthew E. , Ridenhour Suzanne , Meers Grace M. , Hsu Fong-Fu , Turk John , Ibdah Jamal A. 
Published: January 2013

Abstract

Earlier reports suggest a link between mitochondrial dysfunction and development of hepatic insulin resistance. Here we used a murine model heterozygous (HET) for a mitochondrial trifunctional protein (MTP) gene defect to determine if a primary defect in mitochondrial long-chain fatty acid oxidation disrupts hepatic insulin action. Hyperinsulinemic-euglycemic clamps and signaling studies were performed for assessment of whole-body and hepatic insulin resistance/signaling. In addition, hepatic fatty acid oxidation and hepatic insulin action were assessed

in vitro

using primary hepatocytes isolated from HET and wildtype (WT) mice. In both hepatic mitochondria and isolated primary hepatocytes, heterozygosity of MTP caused an ˜50% reduction in mitochondrial fatty acid oxidation, a significantly impaired glucose disposal during the insulin clamp, and a markedly lower insulin-stimulated suppression of hepatic glucose production. HET mice also exhibited impaired insulin signaling, with increased hepatic phosphorylation of IRS2 (ser731) and reduced Akt phosphorylation (ser473) in both hepatic tissue and isolated primary hepatocytes. Assessment of insulin-stimulated FOXO1/phospho-FOXO1 protein content and PEPCK/G6Pase messenger RNA (mRNA) expression did not reveal differences between HET and WT mice. However, insulin-induced phosphorylation of GSK3β was significantly blunted in HET mice. Hepatic insulin resistance was associated with an increased methylation status of the catalytic subunit of protein phosphatase 2A (PP2A-C), but was not associated with differences in hepatic diacylglycerol content, activated protein kinase C-ε (PKC-ε), inhibitor κB kinase β (IKK-β), c-Jun N-terminal kinase (JNK), or phospho-JNK protein contents. Surprisingly, hepatic ceramides were significantly lower in the HET mice compared with WT.

Conclusion

: A primary defect in mitochondrial fatty acid β-oxidation causes hepatic insulin resistance selective to hepatic glycogen metabolism that is associated with elevated methylated PP2A-C, but independent of other mechanisms commonly considered responsible for insulin resistance.