bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antibiotic stewardship in the emergency department setting: Focus on oral antibiotic selection for adults with skin and soft tissue infections
Authors: Draper Heather M , Rybak Michael J , LaPlante Kerry L , Lodise Thomas , Sakoulas George , Burk Muriel , Cunningham Francesca E 
Published: July 2024

Abstract

Purpose
An advisory panel of experts was convened by the ASHP Foundation as a part of its Medication-Use Evaluation Resources initiative to provide commentary on an approach to antibiotic stewardship in the treatment of skin and soft tissue infections (SSTIs), with a focus on oral antibiotics in the emergency department (ED) setting for patients who will be treated as outpatients. Considerations include a need to update existing guidelines to reflect new antibiotics and susceptibility patterns, patient-specific criteria impacting antibiotic selection, and logistics unique to the ED setting.

Summary
While national guidelines serve as the gold standard on which to base SSTI treatment decisions, our advisory panel stressed that institutional guidelines must be regularly updated and grounded in local antimicrobial resistance patterns, patient-specific factors, and logistical considerations. Convening a team of experts locally to establish institution-specific guidelines as part of a comprehensive antibiotic stewardship program can ensure patients receive the most appropriate oral therapy for the outpatient treatment of SSTIs in patients visiting the ED.

Conclusion
SSTI treatment considerations for antibiotic selection in the ED supported by current, evidence-based guidelines, including guidance on optimal oral antibiotic selection for patients discharged for outpatient treatment, are a useful tool to improve the quality and efficiency of care, enhance patient-centric outcomes and satisfaction, decrease healthcare costs, and reduce overuse of antibiotics.
Insular and limbic abnormal functional connectivity in early-stage Parkinson’s disease patients with autonomic dysfunction
Authors: Conti Matteo , Garasto Elena , Bovenzi Roberta , Ferrari Valerio , Mercuri Nicola B , Di Giuliano Francesca , Cerroni Rocco , Pierantozzi Mariangela , Schirinzi Tommaso , Stefani Alessandro , Rocchi Camilla 
Published: July 2024

Abstract
Autonomic symptoms in Parkinson’s disease result from variable involvement of the central and peripheral systems, but many aspects remain unclear. The analysis of functional connectivity has shown promising results in assessing the pathophysiology of Parkinson’s disease. This study aims to investigate the association between autonomic symptoms and cortical functional connectivity in early Parkinson’s disease patients using high-density EEG. 53 early Parkinson’s disease patients (F/M 18/35) and 49 controls (F/M 20/29) were included. Autonomic symptoms were evaluated using the Scales for Outcomes in Parkinson’s disease–Autonomic Dysfunction score. Data were recorded with a 64-channel EEG system. We analyzed cortical functional connectivity, based on weighted phase-lag index, in θ-α-β-low-γ bands. A network-based statistic was used to perform linear regression between Scales for Outcomes in Parkinson’s disease–Autonomic Dysfunction score and functional connectivity in Parkinson’s disease patients. We observed a positive relation between the Scales for Outcomes in Parkinson’s disease–Autonomic Dysfunction score and α-functional connectivity (network τ = 2.8, P = 0.038). Regions with higher degrees were insula and limbic lobe. Moreover, we found positive correlations between the mean connectivity of this network and the gastrointestinal, cardiovascular, and thermoregulatory domains of Scales for Outcomes in Parkinson’s disease–Autonomic Dysfunction. Our results revealed abnormal functional connectivity in specific areas in Parkinson’s disease patients with greater autonomic symptoms. Insula and limbic areas play a significant role in the regulation of the autonomic system. Increased functional connectivity in these regions might represent the central compensatory mechanism of peripheral autonomic dysfunction in Parkinson’s disease.
2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Risk Assessment, Diagnostic Imaging, and Microbiological Evaluation in Adults, Children, and Pregnant People
Authors: Bonomo Robert A , Chow Anthony W , Edwards Morven S , Humphries Romney , Tamma Pranita D , Abrahamian Fredrick M , Bessesen Mary , Dellinger E Patchen , Goldstein Ellie , Hayden Mary K , Kaye Keith S , Potoski Brian A , Rodríguez-Baño Jesús , Sawyer Robert , Skalweit Marion , Snydman David R , Pahlke Sarah , Donnelly Katelyn , Loveless Jennifer 
Published: July 2024

Abstract
As the first part of an update to the clinical practice guideline on the diagnosis and management of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the Infectious Diseases Society of America, the panel presents 21 updated recommendations. These recommendations span risk assessment, diagnostic imaging, and microbiological evaluation. The panel's recommendations are based on evidence derived from systematic literature reviews and adhere to a standardized methodology for rating the certainty of evidence and strength of recommendation according to the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach.
The Composition Date of the Itinerarium Peregrinorum et Gesta Regis Ricardi (IP2) Reconsidered
Authors: Spencer Stephen J 
Published: July 2024

Abstract
Since Hans Eberhard Mayer’s ground-breaking study of 1962, scholars have almost invariably dated one of the longest western narratives of the Third Crusade, the compilation known as the Itinerarium peregrinorum et gesta regis Ricardi, or IP2, to 1216–22. Challenging this deep-rooted view, this article proposes an earlier composition date and, in turn, casts new light on the work’s purpose and the circumstances of its creation. An analysis of both the text itself and crucial evidence for its early reception at Coggeshall Abbey indicates that IP2 was written at some point between 1194 and circa 1201, and most probably in the period 1197–1201. Reflecting on the wider ramifications of this re-dating, it is argued that two fundamental assumptions surrounding the text’s composition require revision: that IP2 was the work of Richard de Templo, prior of Holy Trinity, Aldgate; and that it was composed with a recruitment or political agenda in mind. The article contends that Richard de Templo’s predecessor at Holy Trinity, Prior Peter of Cornwall, played a prominent role in the composition process, almost certainly commissioning the work and probably overseeing its creation, while the compiler’s source selection, the text’s format and the intellectual climate in which it was produced instead point to the guiding principle of preservation: that IP2 was compiled to preserve the story of the Third Crusade, and King Richard I of England’s crusading exploits, for posterity.
Pilot study of a heart-healthy food box intervention for Native Americans with uncontrolled hypertension: methods and results from the Chickasaw Healthy Eating Environments Research Study
Authors: Taniguchi Tori , Williams-Nguyen Jessica , Muller Clemma S , Fyfe-Johnson Amber , Henderson Austin , Umans Jason G , Standridge Joy , Shackleford Tyra , Rosenman Robert , Buchwald Dedra , Jernigan Valarie Bluebird 
Published: July 2024

Abstract
We sought to evaluate the acceptability and feasibility of a culturally tailored food box intervention for improving blood pressure (BP), food security and Body Mass Index (BMI) among Chickasaw Nation adults with uncontrolled hypertension. As part of the Chickasaw Healthy Eating Environments Research Study (CHEERS), we administered a group randomized pilot study in four tribal communities (two intervention, two control). Participants in the intervention communities received six heart-healthy food boxes, culturally tailored to traditional Chickasaw diet and current food context. Outcomes were measured over 6 months. We enrolled 262 participants, and 204 with complete data on key variables were included in the analysis. The food boxes were very popular, and we achieved high retention for follow-up data collection. Intervention community participants had 2.6 mmHg lower mean systolic BP and improved diet quality and BMI compared with control participants, although, as expected for a pilot study, the differences were not statistically significant. The culturally tailored diet intervention and randomized trial study design were acceptable and feasible for Chickasaw Nation adults with uncontrolled hypertension. Our findings support the value of tribal-food bank partnerships as a potential approach for reducing food insecurity and hypertension-related disparities in Native American communities.
Cost-effectiveness evaluation of mass-rearing Cadra cautella (Lepidoptera: Pyralidae) based on harvest theory for sustainable alternative prey production
Authors: Lin Ya-Ying , Hung Yi-Ting , Tuan Shu-Jen , Güncan Ali , Saska Pavel , Yao Me-Chi , Tang Cheng-Kang 
Published: July 2024

Abstract
Cadra cautella (Walker) (Lepidoptera: Pyralidae) is a pest in barn, and its eggs are often utilized as an alternative prey or as hosts for mass production of insect predators and parasitoids. To aid in developing a mass-rearing system for C. castella, the suitability of using an artificial diet based on brown rice flour and whole brown rice was compared using the age-stage, 2-sex life table. Compared with those reared on brown rice, the insects reared on an artificial diet had a shorter preadult period (32.08 vs 37.38 d), higher fecundity (468.14 vs 356.20 eggs/female), greater intrinsic rate of increase (0.1509 vs 0.1145 d−1), and higher net reproductive rate (199.28 vs 103.52 offspring). Small populations were required to rear the moth on an artificial diet to achieve the same daily production of C. cautella. Still, the food expense was only 60.2% of that of C. cautella reared on brown rice. Approximately 99.44% of the eggs in each rearing procedure could be supplied as alternative prey for predators, with the remainder served to maintain the colonies for subsequent batches. Only eggs laid within 6 d would be utilized to ensure the high quality of alternative prey for the mass production of predacious bugs. Additionally, a multifunctional device was designed for moth rearing and egg collection, reducing labor input and minimizing health risks for workers coping with inhaled scales. To encourage the production of natural enemies, a cost-effective diet for maintaining a sustainable colony, and a system for daily egg-harvesting of alternative prey were proposed.
Pan-cancer bioinformatics indicates zinc finger protein 207 is a promising prognostic biomarker and immunotherapeutic target
Authors: Hu Qinglin , Yue Bing , Liu Jing , Gao Yuxia , Huang Xin , Hu Yi 
Published: July 2024

Abstract
In the era of personalized cancer treatment, understanding the complexities of tumor biology and immune modulation is paramount. This comprehensive analysis delves into the multifaceted role of zinc finger protein 207 (ZNF207) in pan-cancer, shedding light on its involvement in tumorigenesis, immune evasion, and therapeutic implications. Through integrated genomic and clinical data analysis, we reveal consistent upregulation of ZNF207 across diverse cancer types, highlighting its potential as a prognostic marker and therapeutic target, particularly for liver cancers. Notably, ZNF207 demonstrates intricate associations with clinical–pathological features, immune subtypes, and molecular pathways, indicating its pervasive influence in cancer biology. Furthermore, our study uncovers ZNF207's involvement in immune escape mechanisms, suggesting its potential as a modulator of immune responses within the tumor microenvironment. These findings underscore the significance of ZNF207 in shaping cancer progression and immune landscape, presenting promising avenues for targeted therapy and immunomodulation. Recognizing ZNF207's multifaceted contributions to cancer progression and immune evasion suggests its central role in understanding tumor immunology, beyond mere therapeutic targeting. Nevertheless, further mechanistic studies are imperative to elucidate ZNF207's precise molecular mechanisms and therapeutic implications in cancer treatment. This study primarily utilized various bioinformatics tools such as TIMER 2.0, cProSite, UALCAN, SangerBox, GEPIA2, TISIDB, and TIDE to analyze the expression of ZNF207 in multiple cancer samples from the TCGA database.
XMM–Newton Ultra Narrow Deep Field survey – II. X-ray spectral analysis of the brightest AGN population
Authors: Elías-Chávez M , Longinotti A L , Krongold Y , Rosa-González D , Vignali C , Mathur S , Miyaji T , Mayya Y D , Nicastro F 
Published: July 2024

ABSTRACT
In this work, we present the results of a detailed X-ray spectral analysis of the brightest active galactic nuclei (AGNs) detected in the XMM–Newton 1.75 Ms Ultra Narrow Deep Field. We analysed 23 AGNs that have a luminosity range of $\sim 10^{42} {\!-\!} 10^{46}\, \rm {erg}\, \rm {s}^{-1}$ in the $2 {\!-\!} 10\, \rm {keV}$ energy band, redshifts up to 2.66, and $\sim 10\,000$ X-ray photon counts in the $0.3{ \!-\! }10\, \rm {keV}$ energy band. Our analysis confirms the ‘Iwasawa–Taniguchi effect,’ an anticorrelation between the X-ray luminosity ($L_x$) and the Fe–k$\alpha$ equivalent width (${\rm EW}_{\rm Fe}$) possibly associated with the decreasing of the torus covering factor as the AGN luminosity increases. We investigated the relationship among black hole mass ($M_{\rm BH}$), $L_x$, and X-ray variability, quantified by the Normalized Excess Variance ($\sigma ^2_{\rm rms}$). Our analysis suggest an anticorrelation in both $M_{\rm BH} - \sigma ^2_{\rm rms}$ and $L_x- \sigma ^2_{\rm rms}$ relations. The first is described as $\sigma ^2_{\rm rms} \propto M^{-0.26 \pm 0.05}_{\rm BH}$, while the second presents a similar trend with $\sigma ^2_{\rm rms} \propto L_{x}^{-0.31 \pm 0.04}$. These results support the idea that the luminosity–variability anticorrelation is a byproduct of an intrinsic relationship between the BH mass and the X-ray variability, through the size of the emitting region. Finally, we found a strong correlation among the Eddington ratio ($\lambda _{\rm Edd}$), the hard X-ray photon index ($\Gamma$), and the illumination factor $\log (A)$, which is related to the ratio between the number of Compton scattered photons and the number of seed photons. The $\log (\lambda _{\rm Edd})-\Gamma -\log (A)$ plane could arise naturally from the connection between the accretion flow and the hot corona.
Broad absorption line quasars in the Dark Energy Spectroscopic Instrument Early Data Release
Authors: Filbert S , Martini P , Seebaluck K , Ennesser L , Alexander D M , Bault A , Brodzeller A , Herrera-Alcantar H K , Montero-Camacho P , Pérez-Ràfols I , Ramírez-Pérez C , Ravoux C , Tan T , Aguilar J , Ahlen S , Bailey S , Brooks D , Claybaugh T , Dawson K , de la Macorra A , Doel P , Fanning K , Font-Ribera A , Forero-Romero J E , Gontcho A Gontcho S , Guy J , Kirkby D , Kremin A , Magneville C , Manera M , Meisner A , Miquel R , Moustakas J , Nie J , Percival W J , Prada F , Rezaie M , Rossi G , Sanchez E , Schubnell M , Seo H , Tarlé G , Weaver B A , Zhou Z 
Published: July 2024

ABSTRACT
Broad absorption line (BAL) quasars are characterized by gas clouds that absorb flux at the wavelength of common quasar spectral features, although blueshifted by velocities that can exceed $0.1c$. BAL features are interesting as signatures of significant feedback, yet they can also compromise cosmological studies with quasars by distorting the shape of the most prominent quasar emission lines, impacting redshift accuracy and measurements of the matter density distribution traced by the Lyman $\alpha$ forest. We present a catalogue of BAL quasars discovered in the Dark Energy Spectroscopic Instrument (DESI) survey Early Data Release, which were observed as part of DESI Survey Validation, as well as the first two months of the main survey. We describe our method to automatically identify BAL quasars in DESI data, the quantities we measure for each BAL, and investigate the completeness and purity of this method with mock DESI observations. We mask the wavelengths of the BAL features and re-evaluate each BAL quasar redshift, finding new redshifts which are $243\, {\rm km}\, {\rm s}^{-1}$ smaller on average for the BAL quasar sample. These new, more accurate redshifts are important to obtain the best measurements of quasar clustering, especially at small scales. Finally, we present some spectra of rarer classes of BALs that illustrate the potential of DESI data to identify such populations for further study.
New rotational rate coefficients computation of the linear NaC3N(X1Σ+) by collision with He(1S) and astrophysical implication
Authors: Terzi N , Khadri F , Hammami K 
Published: July 2024

ABSTRACT
For a better understanding of the physico-chemistry in the interstellar medium, collisional data are needed. In this work, we provide rate coefficients for the recently detected by Cabezas and collaborators in 2023 sodium cyanoacetylide molecule NaC$_{3}$N($X^{1}\Sigma ^{+}$) induced by collisions with He. A new two-dimensional potential energy surface (2D-PES) is derived by adopting the high-level theory of the explicitly correlated coupled cluster with single, double, and perturbative triple excitations (CCSD(T)-F12) in conjunction with the aug-cc-pVTZ basis sets. Our 2D-PES presents two minima: the global one with a well depth of $-86.58$ cm$^{-1}$ and the second well with a $-47.01$ cm$^{-1}$ depth. This was expected by the Natural Bond Orbital analysis showing two electrophilic zones located on Na and N linked Carbon with respective atomic charges : $+0.96575$ and $+0.28910$. This PES was used to calculate inelastic cross-sections within the framework of the close-coupling theory for total energies $\le 170$ cm$^{-1}$ and $J\le 22$. Using the Maxwell–Boltzmann distribution of kinetic energies, these cross-sections were integrated to generate the collisional (de)-excitation rate coefficients for temperatures below 30 K. In order to estimate the impact of the computed collisional rates, a non-local thermodynamical equilibrium radiative transfer calculation was performed. The new collisional data can allow accurate NaC$_{3}$N abundance determination in the interstellar medium.
RESC14 and RESC8 cooperate to mediate RESC function and dynamics during trypanosome RNA editing
Authors: Wackowski Katherine , Zhu Xiaoyu , Shen Shichen , Zhang Ming , Qu Jun , Read Laurie K 
Published: July 2024

Abstract
Mitochondrial transcripts in Trypanosoma brucei require extensive uridine insertion/deletion RNA editing to generate translatable open reading frames. The RNA editing substrate binding complex (RESC) serves as the scaffold that coordinates the protein–protein and protein–RNA interactions during editing. RESC broadly contains two modules termed the guide RNA binding complex (GRBC) and the RNA editing mediator complex (REMC), as well as organizer proteins. How the protein and RNA components of RESC dynamically interact to facilitate editing is not well understood. Here, we examine the roles of organizer proteins, RESC8 and RESC14, in facilitating RESC dynamics. High-throughput sequencing of editing intermediates reveals an overlapping RESC8 and RESC14 function during editing progression across multiple transcripts. Blue native PAGE analysis demonstrates that RESC14 is essential for incorporation of RESC8 into a large RNA-containing complex, while RESC8 is important in recruiting a smaller ribonucleoprotein complex (RNP) to this large complex. Proximity labeling shows that RESC14 is important for stable RESC protein–protein interactions, as well as RESC–RECC associations. Together, our data support a model in which RESC14 is necessary for assembly of editing competent RESC through recruitment of an RNP containing RESC8, GRBC and gRNA to REMC and mRNA.
Phosphorylation at the disordered N-end makes HuR accumulate and dimerize in the cytoplasm
Authors: Baños-Jaime Blanca , Corrales-Guerrero Laura , Pérez-Mejías Gonzalo , Rejano-Gordillo Claudia M , Velázquez-Campoy Adrián , Martínez-Cruz Luis Alfonso , Martínez-Chantar María Luz , De la Rosa Miguel A , Díaz-Moreno Irene 
Published: July 2024

Abstract
Human antigen R (HuR) is an RNA binding protein mainly involved in maintaining the stability and controlling the translation of mRNAs, critical for immune response, cell survival, proliferation and apoptosis. Although HuR is a nuclear protein, its mRNA translational-related function occurs at the cytoplasm, where the oligomeric form of HuR is more abundant. However, the regulation of nucleo-cytoplasmic transport of HuR and its connection with protein oligomerization remain unclear. In this work, we describe the phosphorylation of Tyr5 as a new hallmark for HuR activation. Our biophysical, structural and computational assays using phosphorylated and phosphomimetic HuR proteins demonstrate that phosphorylation of Tyr5 at the disordered N-end stretch induces global changes on HuR dynamics and conformation, modifying the solvent accessible surface of the HuR nucleo-cytoplasmic shuttling (HNS) sequence and releasing regions implicated in HuR dimerization. These findings explain the preferential cytoplasmic accumulation of phosphorylated HuR in HeLa cells, aiding to comprehend the mechanisms underlying HuR nucleus-cytoplasm shuttling and its later dimerization, both of which are relevant in HuR-related pathogenesis.
Single-molecule characterization of SV40 replisome and novel factors: human FPC and Mcm10
Authors: Ouyang Yujing , Al-Amodi Amani , Tehseen Muhammad , Alhudhali Lubna , Shirbini Afnan , Takahashi Masateru , Raducanu Vlad-Stefan , Yi Gang , Danazumi Ammar Usman , De Biasio Alfredo , Hamdan Samir M 
Published: July 2024

Abstract
The simian virus 40 (SV40) replisome only encodes for its helicase; large T-antigen (L-Tag), while relying on the host for the remaining proteins, making it an intriguing model system. Despite being one of the earliest reconstituted eukaryotic systems, the interactions coordinating its activities and the identification of new factors remain largely unexplored. Herein, we in vitro reconstituted the SV40 replisome activities at the single-molecule level, including DNA unwinding by L-Tag and the single-stranded DNA-binding protein Replication Protein A (RPA), primer extension by DNA polymerase δ, and their concerted leading-strand synthesis. We show that RPA stimulates the processivity of L-Tag without altering its rate and that DNA polymerase δ forms a stable complex with L-Tag during leading-strand synthesis. Furthermore, similar to human and budding yeast Cdc45–MCM–GINS helicase, L-Tag uses the fork protection complex (FPC) and the mini-chromosome maintenance protein 10 (Mcm10) during synthesis. Hereby, we demonstrate that FPC increases this rate, and both FPC and Mcm10 increase the processivity by stabilizing stalled replisomes and increasing their chances of restarting synthesis. The detailed kinetics and novel factors of the SV40 replisome establish it as a closer mimic of the host replisome and expand its application as a model replication system.