bluuebunny/crossref_metadata_2025_split huggingface dataset:
A collaborative approach to perinatal and infant mental health service delivery in Australia
Authors: van der Ham Joyce , Berry Karen , Hoehn Elisabeth , Fraser Jennifer 
Published: May 2013

Objective: The objective of this paper is to report on the development and implementation of a community-based perinatal and infant mental health day program for mothers with psychiatric illness. The program was initiated through interagency collaboration between adult mental health, infant mental health and community child health services in Queensland, Australia in response to calls for an integrated approach that could be delivered state-wide if successful. Preliminary results of the program’s evaluation are provided. Method: A pre-post survey design was used to assess the influence the program had on maternal mental and emotional well-being and the maternal-infant relationship. Twenty-one women receiving treatment for perinatal mental illness gave consent to attend the 6-week day program integrating three currently separate and discrete services: adult mental health, infant mental health and community child health. Results: Clinically and statistically significant improvements were observed for maternal mental health, and parent-infant relationships following the program. Conclusions: These findings support interagency collaboration between adult mental health, infant mental health and community child health services to deliver services to women with mental illness with newborns and their families. The utility of using a collaborative approach in a community setting endorses more comprehensive and longer-term evaluation of effectiveness and cost benefit.
Convergence of Halley’s method for operators with the bounded second Fréchet-derivative in Banach spaces
Authors: Argyros Ioannis K , Cho Yeol Je , Ren Hongmin 
Published: May 2013

Abstract
In this paper, we present a semi-local convergence analysis of Halley’s method for approximating a locally unique solution of a nonlinear equation in a Banach space setting, where we assume that the second Fréchet-derivative is bounded. Numerical examples are used to show that the new convergence criteria can provide better information than those provided by the convergence criteria developed earlier.

MSC:65G99, 65J15, 65H10, 47H17, 49M15.
Genetic parameters and genome-wide association study of hyperpigmentation of the visceral peritoneum in chickens
Authors: Luo Chenglong , Qu Hao , Wang Jie , Wang Yan , Ma Jie , Li Chunyu , Yang Chunfen , Hu Xiaoxiang , Li Ning , Shu Dingming 
Published: May 2013

AbstractBackgroundHyperpigmentation of the visceral peritoneum (HVP) has recently garnered much attention in the poultry industry because of the possible risk to the health of affected animals and the damage it causes to the appearance of commercial chicken carcasses. However, the heritable characters of HVP remain unclear. The objective of this study was to investigate the genetic parameters of HVP by genome-wide association study (GWAS) in chickens.ResultsHVP was found to be influenced by genetic factors, with a heritability score of 0.33. HVP had positive genetic correlations with growth and carcass traits, such as leg muscle weight (rg = 0.34), but had negative genetic correlations with immune traits, such as the antibody response to Newcastle disease virus (rg = −0.42). The GWAS for HVP using 39,833 single nucleotide polymorphisms indicated the genetic factors associated with HVP displayed an additive effect rather than a dominance effect. In addition, we determined that three genomic regions, involving the 50.5–54.0 Mb region of chicken (Gallus gallus) chromosome 1 (GGA1), the 58.5–60.5 Mb region of GGA1, and the 10.5–12.0 Mb region of GGA20, were strongly associated (P < 6.28 × 10-7) with HVP in chickens. Variants in these regions explained >50% of additive genetic variance for HVP. This study also confirmed that expression ofBMP7, which codes for a bone morphogenetic protein and is located in one of the candidate regions, was significantly higher in the visceral peritoneum of Huiyang Beard chickens with HVP than in that of chickens without pigmentation (P < 0.05).ConclusionsHVP is a quantitative trait with moderate heritability. Genomic variants resulting in HVP were identified on GGA1 and GGA20, and expression of theBMP7gene appears to be upregulated in HVP-affected chickens. Findings from this study should be used as a basis for further functional validation of candidate genes involved in HVP.
A simple and reproducible breast cancer prognostic test
Authors: Marchionni Luigi , Afsari Bahman , Geman Donald , Leek Jeffrey T 
Published: May 2013

AbstractBackgroundA small number of prognostic and predictive tests based on gene expression are currently offered as reference laboratory tests. In contrast to such success stories, a number of flaws and errors have recently been identified in other genomic-based predictors and the success rate for developing clinically useful genomic signatures is low. These errors have led to widespread concerns about the protocols for conducting and reporting of computational research. As a result, a need has emerged for a template for reproducible development of genomic signatures that incorporates full transparency, data sharing and statistical robustness.ResultsHere we present the first fully reproducible analysis of the data used to train and test MammaPrint, an FDA-cleared prognostic test for breast cancer based on a 70-gene expression signature. We provide all the software and documentation necessary for researchers to build and evaluate genomic classifiers based on these data. As an example of the utility of this reproducible research resource, we develop a simple prognostic classifier that uses only 16 genes from the MammaPrint signature and is equally accurate in predicting 5-year disease free survival.ConclusionsOur study provides a prototypic example for reproducible development of computational algorithms for learning prognostic biomarkers in the era of personalized medicine.
Dissociation of understanding from applying others’ false beliefs in remitted schizophrenia: evidence from a computerized referential communication task
Authors: Wang Yong-guang , Roberts David L , Xu Bai-hua 
Published: May 2013

Abstract

Background
In research on theory of mind (ToM), false belief paradigms are commonly used. Previous studies have reported that there is heterogeneity in the magnitude of impairment on false belief tasks. Moreover, intact ability to attribute others’ false beliefs has been widely reported in patients with remitted schizophrenia. Increasingly, evidence suggests that there may be different cognitive mechanisms underlying the understanding others’ false beliefs versus applying one’s knowledge of others’ false beliefs. Since the role of psychotic symptoms in ToM impairments is an important issue in the study of ToM deficits in schizophrenia, we examined both remitted schizophrenia and non-remitted schizophrenia, with the aim to investigate whether psychotic symptoms in schizophrenia are associated with deficits in understanding others’ mental states or difficulties in applying this understanding.

Methods
The present study investigated 29 patients with non-remitted schizophrenia, 19 patients with remitted schizophrenia, and 22 healthy controls with a revised computerized referential communication task. The ability to understand others’ false beliefs and the ability to apply others’ false beliefs were measured separately.

Results
Patients with non-remitted schizophrenia performed significantly worse than patients with remitted schizophrenia and healthy controls on a task of understanding others’ false beliefs, whereas no significant difference was found between the patients with remitted schizophrenia and healthy controls. Both the patients with non-remitted schizophrenia and patients with remitted schizophrenia performed significantly worse than healthy controls on a task of applying others’ false beliefs.

Conclusions
Our findings suggested a dissociation of understanding others’ false beliefs from applying others’ false beliefs in remitted schizophrenia. We preliminarily conclude that deficits in the ToM ability of applying knowledge of others’ mental states might be state-dependent.
Validation of suitable endogenous control genes for quantitative PCR analysis of microRNA gene expression in a rat model of endometrial cancer
Authors: Jurcevic Sanja , Olsson Björn , Klinga-Levan Karin 
Published: May 2013

Abstract

Background
MicroRNAs are small RNA molecules that negatively regulate gene expression by translational inhibition or mRNA cleavage. The discovery that abnormal expression of particular miRNAs contributes to human disease, including cancer, has spurred growing interest in analysing expression profiles of these molecules. Quantitative polymerase chain reaction is frequently used for quantification of miRNA expression due to its sensitivity and specificity. To minimize experimental error in this system an appropriate endogenous control gene must be chosen. An ideal endogenous control gene should be expressed at a constant level across all samples and its expression stability should be unaffected by the experimental procedure.

Results
The expression and validation of candidate control genes (4.5S RNA(H) A, Y1, 4.5S RNA(H) B, snoRNA, U87 and U6) was examined in 21 rat cell lines to establish the most suitable endogenous control for miRNA analysis in a rat model of cancer. The stability of these genes was analysed using geNorm and NormFinder algorithms. U87 and snoRNA were identified as the most stable control genes, while Y1 was least stable.

Conclusion
This study identified the control gene that is most suitable for normalizing the miRNA expression data in rat. That reference gene will be useful when miRNAs expression are analyzed in order to find new miRNA markers for endometrial cancer in rat.
A potential threat to malaria elimination: extensive deltamethrin and DDT resistance to Anopheles sinensis from the malaria-endemic areas in China
Authors: Wang Duo-quan , Xia Zhi-gui , Zhou Shui-sen , Zhou Xiao-nong , Wang Ru-bo , Zhang Qing-feng 
Published: May 2013

Abstract

Background
Insecticide resistance in malaria vectors is a growing concern in many countries and requires immediate attention because of the limited chemical arsenal available for vector control. There is lack of systematic and standard monitoring data of malaria vector resistance in the endemic areas, which is essential for the ambitious goal of malaria elimination programme of China.

Methods
In 2010, eight provinces from different malaria endemic region were selected for study areas. Bioassays were performed on F1 progeny of Anopheles sinensis reared from wild-caught females using the standard WHO susceptibility test with diagnostic concentrations of 0.25% deltamethrin and 4% DDT.

Results
For An. sinensis, the results indicated that exposure to 0.25% deltamethrin of F1 families with mortalities ranging from 5.96% to 64.54% and less than 80% mortality to DDT at the diagnostic concentration of 4% across the study areas.

Conclusions

Anopheles sinensis was completely resistant to both deltamethrin and DDT, and resistance to pyrethroid has risen strikingly compared to that recorded during 1990s. The results highlight the importance of longitudinal insecticide resistance monitoring and the urgent need for a better understanding of the status of insecticide resistance in this region.
A low-complexity maximum likelihood decoder for tail-biting trellis
Authors: Wang Xiaotao , Qian Hua , Kang Kai , Xiang Weidong 
Published: May 2013

Abstract
Tail-biting trellises are defined on a circular time axis and can have a smaller number of states than equivalent conventional trellises. Existing circular Viterbi algorithms (CVAs) on the tail-biting trellis are non-convergent and sub-optimal. In this study, we show that the net path metric of each tail-biting path is lower-bounded during the decoding process of the CVA. This property can be applied to remove unnecessary iterations of the CVA and results in a convergent maximum likelihood (ML) decoder. Simulation results show that the proposed algorithm exhibits higher decoding efficiency compared with other existing ML decoders.
Channel condition self-clocked packet scheduling scheme for wireless networks
Authors: Chen Jyh-Ming , Wu Eric Hsiao-Kuang , Lu Hsiang-Wei , Chu Ching-Hsiang , Tsai Meng-Feng 
Published: May 2013

Abstract
Since mobile hosts suffer from burst and location-dependent channel errors in wireless networks, packet fair queueing algorithm in wireline networks cannot be applied directly to wireless networks. Generally, a fair scheduler in a wireless network retains the virtual time of flow when the flow encounters channel errors. This results to the flow having higher priority when it exits from errors, and the system can compensate the lost service for the flow. This causes the lagging flows to capture the shared channel and affects the queueing delay of flows perceiving a clean channel. In this paper, we present a channel condition self-clocked packet scheduling scheme. This algorithm can address the problem and achieve the following goals: (1) steady delay and jitter for flows perceiving an error-free environment, (2) delay and throughput guarantees in an error-free environment, (3) short-term fairness among flows perceiving an error-free environment, and (4) long-term fairness for error system. Our algorithm is based on start-time fair queueing, and the virtual time of flows is reset to contend for forwarding its packet the next time when errors happen for the flow.
Numerical investigation of the effect of cannula placement on thrombosis
Authors: Ong ChiWei , Dokos Socrates , Chan BeeTing , Lim Einly , Abed Amr Al , Osman NoorAzuanBinAbu , Kadiman Suhaini , Lovell Nigel H 
Published: May 2013

Abstract
Despite the rapid advancement of left ventricular assist devices (LVADs), adverse events leading to deaths have been frequently reported in patients implanted with LVADs, including bleeding, infection, thromboembolism, neurological dysfunction and hemolysis.
Cannulation forms an important component with regards to thrombus formation in assisted patients by varying the intraventricular flow distribution in the left ventricle (LV). To investigate the correlation between LVAD cannula placement and potential for thrombus formation, detailed analysis of the intraventricular flow field was carried out in the present study using a two way fluid structure interaction (FSI), axisymmetric model of a passive LV incorporating an inflow cannula. Three different cannula placements were simulated, with device insertion near the LV apex, penetrating one-fourth and mid-way into the LV long axis. The risk of thrombus formation is assessed by analyzing the intraventricular vorticity distribution and its associated vortex intensity, amount of stagnation flow in the ventricle as well as the level of wall shear stress. Our results show that the one-fourth placement of the cannula into the LV achieves the best performance in reducing the risk of thrombus formation. Compared to cannula placement near the apex, higher vortex intensity is achieved at the one-fourth placement, thus increasing wash out of platelets at the ventricular wall. One-fourth LV penetration produced negligible stagnation flow region near the apical wall region, helping to reduce platelet deposition on the surface of the cannula and the ventricular wall.
Successful treatment of a 14-year-old patient with intestinal malrotation with laparoscopic Ladd procedure: case report and literature review
Authors: Nakajima Yuka , Sakata Hiroyuki , Yamaguchi Tomohiro , Yoshie Norichika , Yamada Taihei , Osako Takaaki , Terashima Mariko , Mambo Naomi , Saka Ryuta , Nose Satoko , Sasaki Takashi , Okuyama Hiroomi , Nakao Atsunori , Kotani Joji 
Published: May 2013

Abstract
Midgut malrotation is an anomaly of intestinal rotation that occurs during fetal development and usually presents in the neonatal period. We present a rare case of malrotation in a 14-year-old patient who presented with cramping, generalized right abdominal pain, and vomiting for a duration of one day. A computed tomography abdominal scan and upper gastrointestinal contrast studies showed malrotation of the small bowel without volvulus. Laparoscopy revealed typical Ladd’s bands and a distended flabby third and fourth duodenal portion extrinsically obstructing the misplaced duodeno-jejunal junction. The Ladd procedure, including widening of the mesenteric base and appendectomy, was performed. Symptoms completely resolved in a half-year follow up period. Patients with midgut malrotation may present with vague abdominal pain, intestinal obstruction, or intestinal ischemia. The laparoscopic Ladd procedure is feasible and safe, and it appears to be as effective as the standard open Ladd procedure in the diagnosis and treatment of teenage or adult patients with intestinal malrotation.
Splenectomy increases the survival time of heart allograft via developing immune tolerance
Authors: Zhu Jinguo , Chen Shuzhen , Wang Jinju , Zhang Cheng , Zhang Wei , Liu Peng , Ma Ruilian , Chen Yanfang , Yao Zhen 
Published: May 2013

AbstractBackgroundThe spleen is an active lymphoid organ. The effect of splenectomy on the immune response remains unclear. This study investigated whether splenectomy can induce immune tolerance and has a beneficial role in cardiac allograft.MethodsWistar rats were used for heart donors. The Sprague–Dawley (SD) rats designated as the recipients of heart transplantation (HT) were randomly assigned into four groups: sham, splenectomy, HT, splenectomy + HT. The survival of transplanted hearts was assessed by daily checking of abdominal palpation. At various time points after transplantation, the transplanted hearts were collected and histologically examined; the level of CD4+CD25+T regulatory lymphocytes (Tregs) and rate of lymphocyte apoptosis (annexin-v+PI+cells) in the blood were analyzed by using flow cytometric method.Results1) Splenectomy significantly prolonged the mean survival time of heart allografts (7 ± 1.1 days and 27 ± 1.5 days for HT and splenectomy + HT, respectively; n = 12-14/group, HTvs.splenectomy + HT, p < 0.001); 2) Splenectomy delayed pathological changes (inflammatory cell infiltration, myocardial damage) of the transplanted hearts in splenectomy + HT rats; 3) The level of CD4+CD25+Tregs in the blood of splenectomized rats was significantly increased within 7 days (2.4 ± 0.5%,4.9 ± 1.3% and 5.3 ± 1.0% for sham, splenectomy and splenectomy + HT, respectively; n = 15/group, shamvs.splenectomy or splenectomy + HT, p < 0.05) after splenectomy surgery and gradually decreased to baseline level; 4) Splenectomy increased the rate of lymphocyte apoptosis (day 7: 0.3 ± 0.05%, 3.9 ± 0.9% and 4.1 ± 0.9% for sham, splenectomy and splenectomy + HT, respectively; n = 15/group, shamvs.splenectomy or splenectomy + HT, p < 0.05) in a pattern similar to the change of the CD4+CD25+Tregs in the blood.ConclusionsSplenectomy inhibits the development of pathology and prolongs the survival time of cardiac allograft. The responsible mechanism is associated with induction of immune tolerance via elevating CD4+CD25+Tregs and increasing lymphocyte apoptosis.
Modeling mutant phenotypes and oscillatory dynamics in the Saccharomyces cerevisiae cAMP-PKA pathway
Authors: Gonzales Kevin , Kayıkçı Ömür , Schaeffer David G , Magwene Paul M 
Published: May 2013

Abstract

Background
The cyclic AMP-Protein Kinase A (cAMP-PKA) pathway is an evolutionarily conserved signal transduction mechanism that regulates cellular growth and differentiation in animals and fungi. We present a mathematical model that recapitulates the short-term and long-term dynamics of this pathway in the budding yeast, Saccharomyces cerevisiae. Our model is aimed at recapitulating the dynamics of cAMP signaling for wild-type cells as well as single (pde1
Δ and pde2
Δ) and double (pde1
Δ
pde2
Δ) phosphodiesterase mutants.

Results
Our model focuses on PKA-mediated negative feedback on the activity of phosphodiesterases and the Ras branch of the cAMP-PKA pathway. We show that both of these types of negative feedback are required to reproduce the wild-type signaling behavior that occurs on both short and long time scales, as well as the the observed responses of phosphodiesterase mutants. A novel feature of our model is that, for a wide range of parameters, it predicts that intracellular cAMP concentrations should exhibit decaying oscillatory dynamics in their approach to steady state following glucose stimulation. Experimental measurements of cAMP levels in two genetic backgrounds of S. cerevisiae confirmed the presence of decaying cAMP oscillations as predicted by the model.

Conclusions
Our model of the cAMP-PKA pathway provides new insights into how yeast respond to alterations in their nutrient environment. Because the model has both predictive and explanatory power it will serve as a foundation for future mathematical and experimental studies of this important signaling network.
Housefly larvae hydrolysate: orthogonal optimization of hydrolysis, antioxidant activity, amino acid composition and functional properties
Authors: Wang Juan , Wang Yansheng , Dang Xiangli , Zheng Xiaoxia , Zhang Wenqing 
Published: May 2013

Abstract

Background
Antioxidant, one of the most important food additives, is widely used in food industry. At present, antioxidant is mostly produced by chemical synthesis, which would accumulate to be pathogenic. Therefore, a great interest has been developed to identify and use natural antioxidants. It was showed that there are a lot of antioxidative peptides in protein hydrolysates, possessing strong capacity of inhibiting peroxidation of macro-biomolecular and scavenging free redicals in vivo. Enzymatic hydrolysis used for preparation of antioxidative peptides is a new hot-spot in the field of natural antioxidants. It reacts under mild conditions, with accurate site-specific degradation, good repeatability and few damages to biological activity of protein. Substrates for enzymatic hydrolysis are usually plants and aqua-animals. Insects are also gaining attention because of their rich protein and resource. Antioxidative peptides are potential to be exploited as new natural antioxidant and functional food. There is a huge potential market in medical and cosmetic field as well.

Result
Protein hydrolysate with antioxidant activity was prepared from housefly larvae, by a two-step hydrolysis. Through orthogonal optimization of the hydrolysis conditions, the degree of hydrolysis was determined to be approximately 60%. Fractionated hydrolysate at 25 mg/mL, 2.5 mg/mL and 1 mg/mL exhibited approximately 50%, 60% and 50% of scavenging capacity on superoxide radicals, 1, 1-Diphenyl-2-picrylhydrazyl radicals and hydroxyl radicals, respectively. Hydrolysate did not exhibit substantial ion chelation. Using a linoneic peroxidation system, the inhibition activity of hydrolysate at 20 mg/mL was close to that of 20 μg/mL tertiary butylhydroquinone, suggesting a potential application of hydrolysate in the oil industry as an efficient antioxidant. The lyophilized hydrolysate presented almost 100% solubility at pH 3-pH 9, and maintained nearly 100% activity at pH 5-pH 8 at 0°C- 4°C and room temperature during the first 6 months of storage. Essential amino acids in the hydrolysate accounted for 43% of the total amino acids.

Conclusions
The results suggesting that hydrolysate could be added to food oils as an efficient antioxidant. It might be useful for food additives, diet nutrients and pharmaceutical agents.