bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin
Authors: Garner Andrew P. , Bialucha Carl U. , Sprague Elizabeth R. , Garrett Joan T. , Sheng Qing , Li Sharon , Sineshchekova Olga , Saxena Parmita , Sutton Cammie R. , Chen Dongshu , Chen Yan , Wang Huiqin , Liang Jinsheng , Das Rita , Mosher Rebecca , Gu Jian , Huang Alan , Haubst Nicole , Zehetmeier Carolin , Haberl Manuela , Elis Winfried , Kunz Christian , Heidt Analeah B. , Herlihy Kara , Murtie Joshua , Schuller Alwin , Arteaga Carlos L. , Sellers William R. , Ettenberg Seth A. 
Published: August 2013

Abstract
HER2/HER3 dimerization resulting from overexpression of HER2 or neuregulin (NRG1) in cancer leads to HER3-mediated oncogenic activation of phosphoinositide 3-kinase (PI3K) signaling. Although ligand-blocking HER3 antibodies inhibit NRG1-driven tumor growth, they are ineffective against HER2-driven tumor growth because HER2 activates HER3 in a ligand-independent manner. In this study, we describe a novel HER3 monoclonal antibody (LJM716) that can neutralize multiple modes of HER3 activation, making it a superior candidate for clinical translation as a therapeutic candidate. LJM716 was a potent inhibitor of HER3/AKT phosphorylation and proliferation in HER2-amplified and NRG1-expressing cancer cells, and it displayed single-agent efficacy in tumor xenograft models. Combining LJM716 with agents that target HER2 or EGFR produced synergistic antitumor activity in vitro and in vivo. In particular, combining LJM716 with trastuzumab produced a more potent inhibition of signaling and cell proliferation than trastuzumab/pertuzumab combinations with similar activity in vivo. To elucidate its mechanism of action, we solved the structure of LJM716 bound to HER3, finding that LJM716 bound to an epitope, within domains 2 and 4, that traps HER3 in an inactive conformation. Taken together, our findings establish that LJM716 possesses a novel mechanism of action that, in combination with HER2- or EGFR-targeted agents, may leverage their clinical efficacy in ErbB-driven cancers. Cancer Res; 73(19); 6024–35. ©2013 AACR.
Incidence of Venous Thromboembolism in the Wake of the Clots in Legs Or sTockings after Stroke (CLOTS) Study
Authors: Jain Palbha , Ward Elizabeth , Nevatte Tracy , Roffe Christine 
Published: August 2013

Background and Purpose—
In the United Kingdom, compressive stockings were standard care in all stroke units until the publication of the Clots in Legs Or sTockings after Stroke (CLOTS) trial results in May 2009, which concluded that stockings were ineffective. The aim of this audit was to assess whether this change in practice was associated with any change in venous thromboembolism incidence in routine clinical practice.

Method—
All stroke register entries at the University Hospital of North Staffordshire from 2 years before the publication of the CLOTS trial results to 2 years after were identified and included in this audit. The hospital radiology reporting system was then cross-checked for evidence of venous thromboembolism on computed tomography pulmonary angiogram, ventilation/perfusion lung scan, and leg Doppler reports.

Results—

There were 773 patients in the before cohort and 861 in the after cohort (mean age, 74/74 years; men, 47%/45%; and ischemic stroke, 87%/85%, respectively). Symptomatic venous thromboembolism incidence was the same in both cohorts, 21 (2.7%) in the before cohort and 26 (3.0%) in the after cohort (
P
=0.8). There was a trend toward more deep vein thrombosis (9 [1.2%] versus 19 [2.2%];
P
=0.1) and fewer pulmonary embolisms (12 [1.6%] versus 6 [0.7%];
P
=0.2) in the after cohort.

Conclusions—
Discontinuation of compressive stockings did not increase venous thromboembolism incidence. There was a trend toward more deep vein thrombosis and fewer PEs after CLOTS, which might be because of increased clinical vigilance in the diagnosis of deep vein thrombosis, but a chance variation cannot be excluded.
Deuteronomy 19:15–19 in the Damascus Document and Early Midrash
Authors: Naeh Shlomo , Shemesh Aharon 
Published: August 2013

Abstract
Damascus Document 9:16–10:3—the sectarian rule of testimony—presents serious difficulties that have challenged scholars for years. In light of the evidence from Qumran Cave 4, we suggest an emendation and a new reading of the passage. This reading reflects an understanding of the pentateuchal laws of testimony in Deut 19:15–19, which is markedly different from the conventional reading of this biblical pericope and the established halakhah. A similar understanding of the biblical passage is also echoed in early rabbinic sources.
Towards a Theological Reading of Multifaith Spaces
Authors: Biddington Terry 
Published: August 2013

AbstractDespite the existence of occasional shared or mixed religious spaces in the past, ‘multifaith spaces’ are relatively new phenomena and issues about their purpose, design, management, use and value are still emerging. While there is no ‘theology of multifaith spaces’, this article pursues an initial theological reading asking: how multifaith spaces relate to the heterotopias, non-spaces and Thirdspaces of some social theorists; what the theological issues around multifaith spaces are for those religious believers who use them; what theological approaches and language might begin to name and explore the potential of multifaith spaces for new shared understandings of human identity; and how multifaith spaces relate to notions of God.
What Spirit(s), Which Public(s)? The Pneumatologies of Global Pentecostal-Charismatic Christianity
Authors: Yong Amos 
Published: August 2013

AbstractModern Pentecostalism, named after the Day of Pentecost event in Acts 2, has come to be associated with a theology of the Spirit. Yet whether contemporary pentecostal theology has a coherent understanding of the Spirit, or whether the plurality of pentecostal and charismatic Christianities presume a diversity of pneumatologies instead, are open questions. This article suggests how the many tongues of the Spirit poured out on all flesh on the Day of Pentecost can be said to anticipate the multiplicity of theologies of the Spirit in the present global renewal landscape. Yet it is also precisely herein that historic and contemporary Pentecostalisms and their interfaces with the public square provide opportunities and present challenges for the ongoing discussion of the doctrine of the Spirit in particular and for the public theological task in general.
The Ubiquity of Christ and the Sites of Redemption: William Stringfellow, Ecclesiology and the Powers
Authors: Werntz Myles 
Published: August 2013

AbstractIn current theological discourse, the role of congregations in the struggle against the ‘powers and principalities’ moves in one of two directions: either ‘church’ is treated reductively in terms of what it provides for social gains (and thus not what it provides independently of social activism), or ‘church’ as a particularist space is negated entirely. This article argues that the work of William Stringfellow provides a resource for thinking productively about the role of churches within larger social struggles against what theology has termed ‘the powers and principalities’. In Stringfellow’s work, this article claims, we see a model for how ecclesiastical space and ‘worldly space’ can join together in ways that do not negate the integrity of either ‘church’ or ‘world’, while still making use of the ‘powers’ discourse in theologically productive ways.
The Effects of Prism Adaptation on Egocentric Metric Distance Estimation
Authors: Colombo Allyson R. , Jones Keith S. 
Published: August 2013

Objective: The present experiment evaluated whether training involving throwing transferred to metric distance estimation (i.e., describing in feet and inches the distance between oneself and targets). Background: In prior work, we found that metric estimation training negatively transferred to throwing. We explained our results in terms of cognitive intrusion. The present study tested that possibility by swapping our training and transfer tasks. Method: During pretesting, participants verbally estimated the metric distances between themselves and targets, or they threw a beanbag to targets. During training, participants donned goggles that distorted their vision. While wearing the goggles, they threw a beanbag to targets. Half received feedback. During posttesting, participants removed the distorting goggles and completed the same task that they performed during pretesting. Results: The results indicated that the distorting goggles degraded throwing at the beginning of training, visual feedback improved throwing during training, the effects of training with feedback persisted into the throwing posttest, and the effects of training with feedback did not transfer to the verbal metric estimation posttest. Conclusion: Training involving throwing was effective, but did not transfer to verbal metric distance estimation. This supports our argument that the negative transfer observed in our previous study stemmed from cognitive intrusion. Application: The present experiment suggests that the creation of distance estimation training should begin with a careful analysis of the transfer task, and that distance estimation training programs should explicitly teach trainees that their training will not generalize to all distance estimation tasks.
Evaluation of a Configural Vital Signs Display for Intensive Care Unit Nurses
Authors: Drews Frank A. , Doig Alexa 
Published: August 2013

Objective: The objective was to evaluate a configural vital signs (CVS) display designed to support rapid detection and identification of physiological deterioration by graphically presenting patient vital signs data. Background: Current display technology in the intensive care unit (ICU) is not optimized for fast recognition and identification of physiological changes in patients. To support nurses more effectively, graphical or configural vital signs displays need to be developed and evaluated. Method: A CVS display was developed based on findings from studies of the cognitive work of ICU nurses during patient monitoring. A total of 42 ICU nurses interpreted data presented either in a traditional, numerical format ( n = 21) or on the CVS display ( n = 21). Response time and accuracy in clinical data interpretation (i.e., identification of patient status) were assessed across four scenarios. Results: Data interpretation speed and accuracy improved significantly in the CVS display condition; for example, in one scenario nurses required only half of the time for data interpretation and showed up to 1.9 times higher accuracy in identifying the patient state compared to the numerical display condition. Conclusion: Providing patient information in a configural display with readily visible trends and data variability can improve the speed and accuracy of data interpretation by ICU nurses. Application: Although many studies, including this one, support the use of configural displays, the vast majority of ICU monitoring displays still present clinical data in numerical format. The introduction of configural displays in clinical monitoring has potential to improve patient safety.
Perceptual Grouping Effects on Cursor Movement Expectations
Authors: Dorneich Michael C. , Hamblin Christopher J. , Lancaster Jeff A. , Olofinboba Olu 
Published: August 2013

Objective: Two studies were conducted to develop an understanding of factors that drive user expectations when navigating between discrete elements on a display via a limited degree-of-freedom cursor control device. Background: For the Orion Crew Exploration Vehicle spacecraft, a free-floating cursor with a graphical user interface (GUI) would require an unachievable level of accuracy due to expected acceleration and vibration conditions during dynamic phases of flight. Therefore, Orion program proposed using a “caged” cursor to “jump” from one controllable element (node) on the GUI to another. However, nodes are not likely to be arranged on a rectilinear grid, and so movements between nodes are not obvious. Method: Proximity between nodes, direction of nodes relative to each other, and context features may all contribute to user cursor movement expectations. In an initial study, we examined user expectations based on the nodes themselves. In a second study, we examined the effect of context features on user expectations. Results: The studies established that perceptual grouping effects influence expectations to varying degrees. Based on these results, a simple rule set was developed to support users in building a straightforward mental model that closely matches their natural expectations for cursor movement. Conclusion: The results will help designers of display formats take advantage of the natural context-driven cursor movement expectations of users to reduce navigation errors, increase usability, and decrease access time. Application: The rules set and guidelines tie theory to practice and can be applied in environments where vibration or acceleration are significant, including spacecraft, aircraft, and automobiles.
Comparison of Laser Ablation Using Multidirectional and Forward‐Firing Fiber in Human Thyroid Gland: Experimental Study
Authors: Park Ho Yong , Choi Hyang Hee , Lee Jung Ju , Hwang Seung Ook , Jung Jin Hyang , Sohn Ik‐Bu , Lee Ho , Kim Wan Wook 
Published: August 2013

The aim of this study is to evaluate the differences between forward‐firing and multidirectional lasers and to evaluate the effects of exposure times and power on laser ablation of thyroid tissue. This is an experimental, ex vivo study. The experiments were conducted on 3 thyroid glands using 2 power levels (3 and 5 W) and exposure times (3 and 5 minutes) with forward‐firing and multidirectional lasers. The length and width of the demarcated zone were measured to assess the size of thermal effect. NADPH staining was performed to determine tissue viability. Thermal transformation caused by the forward‐firing laser produced oval necrotic zones, whereas thermal transformation caused by the multidirectional‐firing laser produced clear round necrotic zones, which clearly demarcated in both hematoxylin and eosin staining and NADH staining.
Posterior root of lateral meniscus: the detailed anatomic description on 3T MRI
Authors: You M-W , Park JS , Park SY , Jin W , Ryu KN 
Published: August 2013

Background Although there have been some attempts to reveal the anatomy of the posterior root of the lateral meniscus (PRLM) through cadaver studies, arthroscopy, or imaging, it has not yet been described fully. Purpose To describe clearly the unique features of the PRLM, including its course, configuration, and size, using 3.0-T magnetic resonance imaging (MRI). Material and Methods A total of 105 knee 3.0-T MR examinations of 103 patients with arthroscopically proven intact PRLM were reviewed retrospectively. Based on fat-saturated, proton-density-weighted (PDW) axial/coronal images and PDW sagittal images, the course, configuration, and attachment sites of the PRLM were evaluated. Results The majority of PRLM (76.2%) had two attachment sites: the medial tubercle along the intertubercular crest, just posteromedial to the tibial attachment of the anterior cruciate ligament (ACL), and the posterior slope of the lateral tubercle. The remaining cases (23.8%) had a solitary insertion on the intertubercular area (17 cases), or the posterior slope of the lateral tubercle (eight cases). The PRLM of the intertubercular area appeared as a dark signal line parallel to the tibial plateau on the mid-sagittal image and dark signal foci traversing the intertubercular crest on contiguous coronal images. Conclusion The PRLM inserts mainly in the intertubercular area with a thin, long anterior extension to the point just posteromedial to the tibial attachment of the ACL. It is well delineated on PDW 3.0-T MRI as a dark signal line parallel to the tibial plateau on mid-sagittal images and dark signal foci traversing the intertubercular crest on contiguous coronal images.
Autograft Versus Nonirradiated Allograft Tissue for Anterior Cruciate Ligament Reconstruction
Authors: Mariscalco Michael W. , Magnussen Robert A. , Mehta Divyesh , Hewett Timothy E. , Flanigan David C. , Kaeding Christopher C. 
Published: August 2013

Background: An autograft has traditionally been the gold standard for anterior cruciate ligament reconstruction (ACLR), but the use of allograft tissue has increased in recent years. While numerous studies have demonstrated that irradiated allografts are associated with increased failure rates, some report excellent results after ACLR with nonirradiated allografts. The purpose of this systematic review was to determine whether the use of nonirradiated allograft tissue is associated with poorer outcomes when compared with autografts. Hypothesis: Patients undergoing ACLR with autografts versus nonirradiated allografts will demonstrate no significant differences in graft failure risk, laxity on postoperative physical examination, or differences in patient-oriented outcome scores. Study Design: Systematic review. Methods: A systematic review was performed to identify prospective or retrospective comparative studies (evidence level 1, 2, or 3) of autografts versus nonirradiated allografts for ACLR. Outcome data included graft failure based on clinical findings and instrumented laxity, postoperative laxity on physical examination, and patient-reported outcome scores. Studies were excluded if they did not specify whether the allograft had been irradiated. Quality assessment and data extraction were performed by 2 examiners. Results: Nine studies comparing autografts and nonirradiated allografts were included. Six of the 9 studies compared bone–patellar tendon–bone (BPTB) autografts with BPTB allografts. Two studies compared hamstring tendon autografts to hamstring tendon allografts, and 1 study compared hamstring tendon autografts to tibialis anterior allografts. The mean patient age in 7 of 9 studies ranged from 24.5 to 32 years, with 1 study including only patients older than 40 years and another not reporting patient age. The mean follow-up duration was 24 to 94 months. Six of 9 studies reported clinical graft failure rates, 8 of 9 reported postoperative instrumented laxity measurements, 7 of 9 reported postoperative physical examination findings, and all studies reported patient-reported outcome scores. This review demonstrated no statistically significant difference between autografts and nonirradiated allografts in any outcome measure. Conclusion: No significant differences were found in graft failure rate, postoperative laxity, or patient-reported outcome scores when comparing ACLR with autografts to nonirradiated allografts in this systematic review. These findings apply to patients in their late 20s and early 30s. Caution is advised when considering extrapolation of these findings to younger, more active cohorts.
Are teachers at higher risk of HIV infection than the general population in Burkina Faso?
Authors: Kirakoya-Samadoulougou Fati , Nagot Nicolas , Yaro Seydou , Fao Paulin , Defer Marie-Christine , Ilboudo François , Langani Youssouf , Meda Nicolas , Robert Annie 
Published: August 2013

In order to assess the human immunodeficiency virus (HIV) prevalence among teachers in Burkina Faso, we carried out a national survey in 336 primary and secondary schools from urban and rural areas. Among 2088 teachers who agreed to participate, 1498 (71.7%) provided urine for HIV testing. The crude prevalence of HIV among teachers was 2.8% (95% confidence interval [CI]: 2.0–3.6), with no difference between teachers from primary schools (2.9%, 95%CI: 2.1–4.0) and those from secondary schools (2.5%, 95%CI: 0.5–4.5). Age- and area-standardized HIV prevalence was 1.0% (95%CI: 0.4–1.2) in male teachers, 2.5 times lower than among men in the general population (as assessed from a concomitant Demographic Health Survey), and it was 3.5% (95%CI: 2.5–5.2) in female teachers, 1.7 times higher than in Demographic Health Survey women. This finding calls for the implementation of specific HIV prevention programmes in the education sector targeting women more specifically.
Voices across the fence: commonality, difference and respectful practice across a half century of change
Authors: Hunter Ernest , Milroy Helen 
Published: August 2013

Objective: To describe changes that have occurred in the field of indigenous mental health over the last 50 years. Conclusions: The last half-century has seen major advances in psychiatry and in the roles and capacities of the Royal Australian and New Zealand College of Psychiatrists. Over the same period, Aboriginal and Torres Strait Islander Australia has been transformed by social and political forces that have brought both benefits and disappointments to Indigenous Australians. Indigenous mental health has evolved from a marginal interest in an ‘exotic’ area to a recognised field with its own issues, competencies and training needs. In this paper, two College Fellows consider these decades of change, presenting their reflections through voices that reflect different vantages despite a common destination.
Outcomes After Fixation of Proximal Humerus (OTA Type 11) Fractures in the Elderly Patients Using Modern Techniques
Authors: Shulman Brandon S. , Ong Crispin C. , Lee James H. , Karia Raj , Zuckerman Joseph D. , Egol Kenneth A. 
Published: August 2013

Purpose To investigate the effects of age on the clinical, functional, and radiographic outcomes of patients with proximal humerus fractures treated operatively with locking plates. Methods Between February 2003 and July 2012, all patients who sustained a proximal humerus fracture who presented to our institution were enrolled into a database. Patients were followed up at 1, 6, 12, 26, and 52 weeks postoperatively with physical examination and radiographs. Validated functional outcomes scores were collected at 6 and 12 months. Complications were recorded as they occurred. Statistical analysis was conducted to assess for functional, physical, or radiographic differences between patients age younger than 65 and patients age 65 or older. Results Of the 147 consecutive patients treated operatively for a proximal humerus fracture, 115 (78%) patients with an average follow-up of 16 months met the inclusion criteria for this study. The young cohort (patients < 65) included 70 patients with an average age of 53, whereas the elderly cohort (patients ≥ 65) included 45 patients with an average age of 73. The older cohort had significantly more women ( P = .04), but there was no statistical difference in fracture type between the age groups. There were no differences in the radiographic measures of screw penetration, humeral head height, and neck-shaft angle between the age groups. There were no differences in physical examination scores between the age groups. There were no significant differences in functional outcomes or complication rates between the age groups. Conclusion Treating proximal humerus fractures operatively with locked plates can overcome the challenges of poor bone quality that often occur with increasing age. Age should not play a significant role in the decision-making process for treating proximal humerus fractures that would otherwise be indicated for surgical fixation.
DOCK8 is critical for the survival and function of NKT cells
Authors: Crawford Greg , Enders Anselm , Gileadi Uzi , Stankovic Sanda , Zhang Qian , Lambe Teresa , Crockford Tanya L. , Lockstone Helen E. , Freeman Alexandra , Arkwright Peter D. , Smart Joanne M. , Ma Cindy S. , Tangye Stuart G. , Goodnow Christopher C. , Cerundolo Vincenzo , Godfrey Dale I. , Su Helen C. , Randall Katrina L. , Cornall Richard J. 
Published: August 2013

Key PointsThe development and survival of mature NKT cells are impaired in DOCK8-deficient mice. DOCK8 is required for antigen-induced NKT cell proliferation and cytokine production.