bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reproducible and Sustained Efficacy of Targeted Therapy With Vemurafenib in Patients With BRAFV600E-Mutated Erdheim-Chester Disease
Authors: Haroche Julien , Cohen-Aubart Fleur , Emile Jean-François , Maksud Philippe , Drier Aurélie , Tolédano Dan , Barete Stéphane , Charlotte Frédéric , Cluzel Philippe , Donadieu Jean , Benameur Neïla , Grenier Philippe A. , Besnard Sophie , Ory Jean-Paul , Lifermann François , Idbaih Ahmed , Granel Brigitte , Graffin Bruno , Hervier Baptiste , Arnaud Laurent , Amoura Zahir 
Published: November 2014

Purpose Histiocytoses are rare disorders with heterogeneous prognosis. BRAFV600E mutations have been observed in half of patients with Langerhans cell histiocytosis (LCH) and in 50% to 100% of patients with Erdheim-Chester disease (ECD) patients. We recently reported short-term efficacy of a BRAF inhibitor (vemurafenib) in three patients with multisystemic ECD. Patients and Methods Vemurafenib was given to eight patients with multisystemic ECD with CNS and/or cardiac involvement. All patients were refractory to first-line treatment and harbored a BRAFV600E mutation. Four patients also had LCH lesions. Positron emission tomography (PET) scan response at month 6 was used as the main evaluation criterion. Secondary evaluation criteria were comparison at baseline and at last visit of PET and of cardiovascular and cerebral infiltrations (computed tomography scan and magnetic resonance imaging [MRI]). Results All patients were partial metabolic responders at 6 months of vemurafenib, and the median reduction in maximum standardized uptake value was 63.5% (range, 41.3% to 86.9%). Evaluation of cardiac and aortic infiltrations showed that seven patients had a partial response and one patient had stable disease according to surface measurements derived from RECIST criteria. The four patients with infratentorial CNS infiltration had an objective decrease of the lesions on MRI. All patients had an improvement of general symptoms and a persistent response to vemurafenib, with a median follow-up time of 10.5 months (range, 6 to 16 months). Skin adverse effects were frequent and severe. Conclusion Vemurafenib has an objective and sustained efficacy in BRAFV600E-mutated ECD as second-line therapy. In contrast to melanoma, no resistance has emerged to date after 6 to 16 months.
Comparison of Breast Cancer Recurrence and Outcome Patterns Between Patients Treated From 1986 to 1992 and From 2004 to 2008
Authors: Cossetti Rachel J.D. , Tyldesley Scott K. , Speers Caroline H. , Zheng Yvonne , Gelmon Karen A. 
Published: November 2014

Purpose To determine whether the patterns of relapse according to estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) status changed in the contemporary era. Patients and Methods Female patients referred to the British Columbia Cancer Agency with biopsy-proven stage I to III breast cancer (BC), diagnosed between 1986 and 1992 (cohort 1 [C1]) and between mid-2004 and 2008 (cohort 2 [C2]), and with known ER and HER2 status were eligible. Data were prospectively collected. C2 patients were matched to C1 patients for stage, grade, and ER and HER2 status. The primary end point was hazard rate of relapse (HRR) for BC by study cohort according to biomarker status. Secondary outcomes included HRR according to stage, grade, and age and hazard rate of death (HRD). Results After matching, 7,178 patients were included (3,589 patients in each cohort). BC subtype distribution was as following ER positive/HER2 negative, 70.8%; ER positive/HER2 positive, 6.9%; ER negative/HER2 positive, 6.6%; and ER negative/HER2 negative, 15.8%. For the overall population, the HRR approximately halved in all yearly intervals to year 9 in C2 compared with C1. Differences in HRR between cohorts were greater in the initial five intervals for HER2-positive and ER-negative/HER2-negative BC. The HRR decreased in C2 compared with C1 for all disease stages and grades. The HRD in C2 also decreased compared with C1, although to a lesser extent. Conclusion Although the pattern of relapse remains similar, there has been a significant improvement in BC relapse-free survival. Outcomes have improved for all BC subtypes, especially HER2-positive and ER-negative/HER2-negative BC, with the early spike in disease recurrence markedly decreased. These contemporary hazard rates are important for treatment decisions, patient discussions, and planning clinical trials of early BC.
Commercial sport – Debordian spectacle or Barthesian mythology?
Authors: Møller Verner , Genz Jakob 
Published: November 2014

Abstract
Concern over the corrupting effects of modern sport has been voiced since its birth in the nineteenth century. Its critics have deemed it unhealthy, called it fascist, claimed that it created false conscience, etc. Its advocates, on the other hand, have praised sport’s ability to build character and facilitate understanding and respect between people and nations. But the sport advocates have not been univocal in their appraisal. They have expressed concern that the sporting values have come under threat from professionalization and increased commercialization of sport. In this article, however, we make the case that modern-day sport has qualities that help ground us in the world and, in fact, civilizes. The article starts by exposing the outdatedness of the sociologist John J. MacAloon’s ‘festival nostalgia’. It goes on to take issue with Guy Debord’s criticism of the disempowerment of the people caused by what he calls the ‘society of the spectacle’. Using soccer as the prime example, this is followed by a discussion of the fundamental elements of the fascination exerted by sport and of sport’s significance as modern mythology. We argue that the media-driven commercialization, often looked upon as the root cause of sport’s unfortunate development, is, in fact, part of the engine that propels it forward as a project for the development of popular culture.
Sport and the neo-liberal world order
Authors: Nauright John 
Published: November 2014

Abstract
Sport is a huge global enterprise worth nearly $150 billion annually. As a result international federations and other stakeholders are keen to maintain the veneer of integrity and morality in an idealized vision of sport. The value of sport and what it means to the operation of global sports federations and associated enterprises, most notably the International Olympic Committee (IOC); The International Federation of Football Associations (FIFA); and the World Anti-Doping Agency (WADA), is discussed. In this short viewpoint article I analyse the political economy underpinning the ‘war’ on athletes being waged at present in the name of ‘pure sport’. I argue that ‘pure sport’ and ‘level playing field’ are ideologies used to maintain the power position of major international sporting federations rather than an actual goal of these federations.
Chameleon hair: How hair’s materiality affects its fashionability
Authors: Holmes Helen 
Published: November 2014

Abstract
This article seeks to explore the changeable materiality of hair. Drawing upon the archaeological concept of the palimpsest, as an inimitable material record, it illuminates how hair’s chameleon abilities are the foundation upon which the contemporary hair fashion industry resides. As Nigel Thrift notes, hair ‘is the easiest part of the body to alter. It grows so must be cut’. However, paradoxically, it is hair’s very materiality that also inhibits its conformity to certain fashions. While hair may appear to have chameleon materiality, it has multiple temporalities. And as this article argues, hair is simultaneously changing and changed, but it displays constant features.
As we may publish: Digital scholarship and the future(s) of art education
Authors: Knochel Aaron D. , Patton Ryan M. 
Published: November 2014

Abstract
Qualities of digital scholarship for the arts and humanities are outlined as an ecology of research and pedagogy, expanding the scholarly journal by advancing the possibilities of online publishing. While moving away from paper-based scholarship is the first step, new models of digital scholarship that are multimodal and interactive allow for real-time effects, reflexive research, reconsider intellectual openness through a radical sense of accessibility, and broadly (re)define the textual body in research to one that is transdisciplinary. In this article, we elaborate on the current trends and opportunities in digital scholarship presented by online publications as an extension of research modalities, augmenting what art education research publications look like, presenting new and rich contexts for scholarship. We explore limitations and benefits found in the current state of academic publishing by asking how scholarship can be transformed in a technological ecology.
(Mis)Information highways: A critique of online resources for multicultural art education
Authors: Acuff Joni Boyd 
Published: November 2014

Abstract
This article calls to attention hegemonic online resources for multicultural art education. The author suggests that art educators carefully critique multicultural art lesson plans published online, as the Internet is increasingly a primary resource teachers use to make pedagogical and curricular decisions. The author demonstrates how some multicultural art education resources offered online contribute to an ‘us–other’ dichotomy, and contradict with the current progressive critical multicultural art education scholarship being published by contemporary art education scholars. The author asserts three contentions of support that illustrate how these online curricular resources maintain ‘liberal’ multiculturalism, exoticize cultural groups, produce surface knowledge about difference and fail to question power. This article concludes with a call to action in which art educators are encouraged to explicitly acknowledge, discuss and work with students and peers to build counter-curriculum that work against these damaging online multicultural art education resources.
Integrating Taiwanese culture into design pedagogy
Authors: Hsieh Hsiu Ching Laura 
Published: November 2014

Abstract
Many Taiwanese students enthusiastically accept the consumption cultures of Japan and the United States, but neglect the value of their own culture. Thus, as a design educator, it is necessary to guide the students reflecting on and identifying with their own culture. This pedagogical study adopted qualitative methods and collected and analysed data from interviews, observation on the creation process and related documents. The purposes of this research were: to explore the related research and theories and integrate them as a model of Incorporating Culture into Design Creation; to explore the advantages and challenges of applying the new model to pedagogical practice; and to reflect on the application of the new model to teaching. According to the findings, it is feasible to apply this model to the design pedagogy. The contribution of this study was to encourage the students to recognize the characteristics of their own culture and facilitate their capabilities of incorporating culture into the design creation.
Empathy and aesthetic experience in the art museum
Authors: Arnold Alice , Meggs Susan Martin , Greer Annette G. 
Published: November 2014

Abstract
The purpose of this study was to explore how students’ aesthetic understanding and ability to empathize were impacted by multiple learning experiences in the environment of an art museum. As part of a semester-long class in elementary art methods, education majors experienced a docent-led tour of the local art museum, featuring the work of fibre artist Deidre Scherer. The tour was followed by a series of learning events centred on the exhibit and the study of end-of-life care, the theme of Scherer’s work. Students then answered structured questionnaires prompting them to process the learning events with intentional reflection. A qualitative method of enquiry sought to uncover the lived experiences of the students enrolled in the class. Through these encounters, students developed empathy and understanding as well as the ability to describe the meanings of the art in terms of their own life scenarios.
Role-playing games in arts, research and education
Authors: Cox Jason Matthew 
Published: November 2014

Abstract
Games are increasingly being used as tools to broaden pedagogical options in schools and create interdisciplinary linkages. This article pays particular attention to role-playing games (RPGs), and the applications they have for arts education. RPGs can be used in art classrooms and in arts-based research and as an exciting and useful form of collaborative art-making, interpersonal discourse and reflection. This article is divided into sections describing the games and the manner in which it has been applied to arts education. Interspersed within the article are reflections from the author’s experience in a game that examines the politics of oppression called the The Tribunal, which resulted in introspection on both personal and societal issues. The article concludes that RPGs can help make both personal and communal meaning of experiences and foster the development of empathy.
Review
Authors: Westron Loree 
Published: November 2014

Abstract
Naming the unnameable
‘I Am Your Brother’ Short Story Studies, Charles E. May (2013) Available by print-on-demand, 277 pp., ISBN: 9781490347615, p/bk, £9.35
Morphology, Ra Page (ed.) (2013) Manchester: Comma Press, 204 pp., ISBN: 9781905583485, p/bk, £9.99
Mentoring the contemporary arts student in the university
Authors: Daichendt G. James , Funk Clayton , Swift Jason 
Published: November 2014

Abstract
The roles of professional artists and educators are established and defined by mentors in the field. In addition, they have a large impact on students, and can have a powerful influence on future artists. Our position as mentors becomes one of furthering the knowledge base of the field and passing it down to the next generation. However, we know mentorship to be essential but it is also often misunderstood. Educating, motivating or helping others to become more effective are characteristics that can be developed in university art and art education programmes through the process of mentoring, whether in the classroom, studio, online, or institutions like museums or galleries. Despite the process of mentorship trending outside the traditional classroom, this was not always the case in the history of art education and much can be done through collaboration and effective communication to develop the mentoring process. This article explores the changing landscape of mentoring in the university and considers the deskilled context that favours developing competencies through the concepts of accidental mentoring and mentoring through collaboration.
Art’s asymptotic leadership: Arts leadership, education and the loss of autonomy
Authors: Baldacchino John 
Published: November 2014

Abstract
This article will mostly engage with arts leadership through a discussion that focuses on the arts, leadership and education, and how their convergence might have a direct impact on autonomy. Taking a meta-theoretical approach, the main argument is that arts leadership is an asymptotic state of affairs. Rather than pose art and leadership as antithetical events that necessitate forms of syntheses through identifiable contexts, the context for arts leadership represents a contiguous space where art and leadership continuously seek a mutual way of preserving their integrity in an asymptotic relationship. If this relationship turns into a synthesis, both art’s autonomy and the ability to lead creatively are neutralized. The aim is to question the various implications that bring together the autonomous spheres of the arts, education and leadership, while inviting the reader to draw his or her own conclusions critically and autonomously. To clarify this approach, this article straddles across several horizons, including: arts practice as a sphere of autonomous dispositions and the political implications that follow; education as a horizon that educes – leads out – through the pedagogical exits that are offered by the arts; and art’s anti-systemic pedagogy, where art’s autonomy becomes a possibility of unlearning systems.
Servant leadership in the creative academy
Authors: Hafeli Mary 
Published: November 2014

Abstract
How do the characteristics and behaviours of creative people mesh with their roles as faculty members? How do the opportunities and demands of today’s college environments play into the work lives of arts faculty? And what are the implications of these questions for thinking about how best to lead artists and arts scholars in colleges and universities? This article explores these questions through an examination of servant leadership, an approach that focuses on service as an underlying principle of leadership. Intertwined with a discussion of creative people and optimal characteristics of those who lead them, I describe current conditions of colleges and universities and what being a college leader may be like. I then present characteristics of servant leaders and attempt to draw some parallels between servant leadership behaviours and needs of faculty and students in the arts. Finally, I summarize some potentially positive outcomes of servant leadership as well as some of the model’s possible drawbacks and challenges.
Teaching art where art should not exist: Women’s empowerment in Saudi Arabia
Authors: Congdon Kristin G. 
Published: November 2014

Abstract
Saudi Arabia is perhaps the most conservative country in the Middle East. The display of art is not allowed, or extremely limited, under Sharia law. This article explores a three-week adult art education class taught to women at the Al Baylasan Art Center in Al Khobar, Saudi Arabia. With the goal of empowering women, it challenged two American art educators to develop and present a curriculum that was respectful of the culture but allowed the students to push the limits of their thinking about what might be possible in their changing cultural context.
SummerVision DC: An evolving Professional Learning Community (PLC) explores art museums and nurtures the nurturer
Authors: Sandell Renee , Henry Carole 
Published: November 2014

Abstract
This article discusses the National Art Education Association’s (NAEA) SummerVision DC program, which combines blended learning with ongoing professional development grounded in an intensive four-day expeditionary engagement, exploring diverse museums as vital learning sites while building a professional learning community (PLC). To comprehend the interactive nature of the SummerVision DC experience and its creation of optimal conditions for growing a supportive and professional learning community (PLC) within the museum environment, this article reviews key stages in the evolving process – from virtual preparation/anticipation to actual learning experiences, revealing the interweaving of the preparatory work with museum educators and participants, the hands-on/on-site experiences, the collaboration and relationship building, the time for reflection, the opportunity to apply what one is learning and walk away with lessons that can be used in the classroom, the use of technology to expand and extend the learning (before the event), and the community connections (after the event) that are continued and expanded through social media with ongoing NAEA support for collaborative networking and insightful and creative leadership.
A challenge for art education: Understanding leadership and creating new leaders for public policy development, educational partnerships and teacher training programmes
Authors: Sabol F. Robert 
Published: November 2014

Abstract
The fields of general education and art education are in an unprecedented period of change. Educational leaders at all instructional levels have experienced new challenges, problems and opportunities that required higher levels of creativity, innovation and visionary thinking than ever before. Advances in neuroscience, creativity studies, charter schools, technology, national curriculum standards, high-stake assessments of learning, teacher evaluations and numerous other developments have contributed to making leadership development a priority in all school districts and communities. Opportunities for leadership development and professional learning are limited. In order for the field of art education to meet these growing leadership challenges, the field needs to increase its emphasis on leadership development for all art educators. Those in positions of leadership must engage in and emphasize policy studies in art education. At a fundamental level, art educators and leaders must refine and develop their understanding of the nature and structures of leadership. In order for these things to occur across the nation, creation of professional development opportunities must be made available on an ongoing basis so that art educators can continue to develop and refine their skills as leaders. Among the full array of leadership development needs in art education, there are significant opportunities for leadership growth and involvement in the areas of public policy, educational partnerships and teacher training programmes. Concentrating leadership development in these key areas holds potential for producing leadership outcomes that can positively influence art education in all schools and communities across the country.
Die zunehmende Profilierung der Schreibsilbe in der Geschichte des Deutschen
Authors: Fuhrhop Nanna , Schmidt Karsten 
Published: November 2014

AbstractConcepts like the written syllable, the featural analysis of letter forms and the length hierarchy have led to stunning insights over the last few years. However, they are still very much disputed. The present paper investigates a number of historical developments in the German writing system with regard to the length hierarchy. Many of these changes can be understood (exclusively) as an increasing profiling of the written syllable.
Kritik des Apparats
Authors: Kragl Florian 
Published: November 2014

AbstractOn the occasion of the new ›Laurin‹-edition, this article focuses on the phenomenon of the critical apparatus. Philologists have taken serious efforts in re-examining the standards of editing medieval texts in general over the last decades. However, the apparatus itself has received far less attention. The article discusses the consequences of this disequilibrium for contemporary editions. It proposes a new approach to apparatus design, which takes into account the manifold textual situations we encounter in medieval transmission.
Reflexive differential forms on singular spaces.
Geometry and cohomology
Authors: Greb Daniel , Kebekus Stefan , Peternell Thomas 
Published: November 2014

Abstract

Based on a recent extension theorem for reflexive differential forms, that is,
regular differential forms defined on the smooth locus of a possibly singular
variety, we study the geometry and cohomology of sheaves of reflexive
differentials.

First, we generalise the extension theorem to holomorphic forms on locally
algebraic complex spaces. We investigate the (non-)existence of reflexive
pluri-differentials on singular rationally connected varieties, using a
semistability analysis with respect to movable curve classes. The necessary
foundational material concerning this stability notion is developed in an
appendix to the paper. Moreover, we prove that Kodaira–Akizuki–Nakano
vanishing for sheaves of reflexive differentials holds in certain extreme
cases, and that it fails in general. Finally, topological and Hodge-theoretic
properties of reflexive differentials are explored.