bluuebunny/crossref_metadata_2025_split huggingface dataset:
Management of acquired prostatic fistulas in adults
Authors: Garaz Radion , Mirvald Cristian , Amend Bastian , Surcel Cristian , Tsaur Igor 
Published: June 2024

Abstract
Purpose
Acquired prostatic fistula (PF) was defined as a connection between the prostatic urethra and the rectum, symphysis, peritoneum, or ending freely in the periprostatic area. This study aims to report our experience with PF presentation, diagnosis, and treatment.

Methods
From January 2014 to February 2024, we retrospectively analyzed a prospectively maintained database from two urologic university hospitals to identify men with acquired PF. Diagnosis was based on post-intervention symptoms, including pneumaturia, fecaluria, rectal urine leakage, periprostatic inflammation or abscess, completed by radiological assessment using retrograde urethrogram, CT, or MRI. Standard cystoscopy and/or rectosigmoidoscopy assessed bladder and rectal integrity. Patients with post-prostatectomy fistulas were excluded.

Results
Thirteen patients with a mean age of 66.54 ± 7.40 years were identified. The most commonly presenting symptoms were fecaluria/pneumaturia 54%, rectal urine leakage 31%, and recurrent urinary tract infection 31%. The mean time from the initial treatment to fistula development was 22.28 ± 20.53 months (0.1–59 months), and from diagnosis to repair was 3.5 ± 3 months (1–12 months). Cumulative closure rates (success rate) post-first and second attempts were 77% (10 patients) and 92% (12 patients), respectively; one patient declined definitive surgery, maintaining a persistent fistula after bladder drainage.

Conclusion
Clinical suspicion and detailed diagnosis are essential for formulating a tailored treatment plan for prostatic fistulas, which are successfully manageable in many patients. Complex cases benefit from a multidisciplinary approach, with individualized therapy based on etiology, severity, and recurrence of PF, facilitating effective closure.
Hepatitis E virus in wild and domestic rabbits from Portugal: a combined molecular and longitudinal serological study
Authors: Santos-Silva Sérgio , Santos Nuno , López-López Pedro , Nascimento Maria S. J. , Gonçalves Helena M. R. , Van der Poel Wim H. M. , Rivero-Juarez António , Mesquita João R. 
Published: June 2024

AbstractHepatitis E virus (HEV), species Paslahepevirus balayani, poses a global public health threat, especially in developing countries, by causing acute enterically transmitted hepatitis. HEV infects various mammalian hosts and belongs to the genus Paslahepevirus in the family Hepeviridae. While swine are recognized as the main hosts of HEV, rabbits, which can also be affected by swine HEV-3 related strains, serve as the primary reservoir for the distinct emerging and zoonotic HEV-3ra subtype. In Portugal, where the European wild rabbit is abundant, their role in HEV epidemiology remains unclear. The primary aim of the present research was to evaluate the circulation and the potential for HEV infection within these species. This study employed a molecular and longitudinal serological approach to investigate HEV in Portuguese rabbits. Among the 205 wild rabbits tested, a seroprevalence of 2.44% (95% CI: 0.80–5.60) was found, with no significant associations with age, sex, localization, or sampling dates. Seropositive animals were found in the south and center regions of the country. HEV RNA was not detected in 120 fecal samples, suggesting a natural, low level, and widespread viral circulation. The study underscores the need for further research to comprehend HEV dynamics in these species, which is crucial for assessing potential transmission risks to humans.
Thermal Stress Analysis for Functionally Graded Plates with Modulus Gradation, Part II
Authors: Baytak T. , Tosun M. , Ipek C. , Mollamahmutoglu C. , Bulut O. 
Published: June 2024

Abstract
Background
The gradation of thermal expansion coefficient was analyzed in the earlier study. The analytical formulation derived here, which is quite different, should be validated to understand the thermal stress distribution in a laminated composite and functionally graded material. Besides this solution, a validated numerical model can also be used to optimize the material gradation of plates in terms of sustainability.

Objective
To validate the analytical formulation derived here, an experimental model is presented to understand the thermal stress concentration for functionally graded and laminated composite plates. A numerical model is also validated to extend to understand the effects of the number of layers, the thickness of a layer, the gradation function, the ratio of elastic moduli, and the coating.

Methods
The experimental problems in the production of the experimental models with layers of different elastic moduli are discussed here. In the experimental analysis, a three-dimensional photoelastic stress analysis of two- and four-layer composite plate was used to mechanically model the thermal expansion. The analytical solution for the thermal stress in a free plate was derived by the strain suppression method based on the principle of superposition. The numerical models were analyzed using finite element software. The step variation in the experiment was used as a reference point for a continuous or multi-layer (> 2) step variation of material coefficients in the models.

Results
The variation of stress concentration is shown for various cases of laminated and continuous gradations of elastic modulus. The four-layer experimental model provides the difference in thermal stress distribution as a result of a layered coating. The validated analytical and numerical models provide reasonable results. An empirical formula to optimize the material gradation in terms of elastic modulus is derived.

Conclusions
The experimental model can be used to analyze thermal stress in functionally graded materials. The gradations of the material in the plate or the coating of the plates can be optimized by the validated analytical and numerical models. The empirical formula can be used to determine the elastic modulus of the coating to minimize the stress concentration.
Impacts of public disclosure on tax compliance using agent-based modeling
Authors: Sano Hiroyuki 
Published: June 2024

Abstract
This study examines the impact of public disclosure of tax information on tax compliance using simulation experiments utilizing agent-based modeling. We investigate two scenarios: (i) partial disclosure, in which tax returns and audit results are made public without taxpayer identities, and (ii) full disclosure, in which this information is publicized with taxpayer identities. Our simulation results reveal that in the partial disclosure scenario, the effect on tax compliance is contingent upon the social state of individual moral values regarding tax payment. Specifically, partial disclosure has a positive impact on tax compliance when taxpayers exhibit a relatively strong moral consciousness and a negative impact when their moral consciousness is weak. In the full disclosure scenario, when the moral consciousness of the population is sufficiently weak, the average reported income decreases despite the positive effect of the naming-and-shaming policy on tax compliance.
Measuring Subjective Well-being Capability: A Multi-Country Empirical Analysis in Europe
Authors: Kwarciński Tomasz , Ulman Paweł , Wdowin Julia 
Published: June 2024

AbstractThe main aim of this paper is to conceptualise and empirically estimate subjective well-being capability. The empirical demonstration of the conceptual framework is applied in a selection of European countries: Poland and its leading emigration destinations the United Kingdom, Germany, the Netherlands, Ireland, France and Italy. The paper advances the measure of subjective well-being capability (SWC) as the integration of the subjective well-being measure with the capability approach in a unified measurement framework. Following the development of a conceptual model, the theoretical framework is operationalized empirically to quantify measures of SWC across the selected countries using a Multiple Indicators and Multiple Causes Model. Data from the European Quality of Life Survey is employed. A comparative analysis compares the SWC measures across countries as well as comparing SWC with conventional well-being measures such as overall happiness and GDP per capita. The results of the study reveal a significant correlation between the SWC based on a general model for all countries, overall happiness, and GDP per capita. However, it also suggests that country-specific SWCs, calculated from tailored models, could substantially deviate from traditional well-being measurements. This attribute suggests that SWC could be a practical tool for assessing individual contexts, as reflected in the tailored models, even though it might not serve as the optimal instrument for country ranking (via the general MIMIC model).
Wie entwickeln sich behinderungsbezogene Einstellungen im Verlauf eines Freiwilligen Soziales Jahres? Eine Analyse latenter Wachstumskurvenmodelle
Authors: Meyer Karina , Willems Ariane S. 
Published: June 2024

ZusammenfassungIm Kontext von Inklusion spielen Einstellungen eine wichtige Rolle und das Freiwillige Soziale Jahr ist durch die Kombination von persönlichen Kontakterfahrungen und pädagogischer Begleitung in besonderer Weise geeignet, positive Einstellungen zu Menschen mit Behinderung zu fördern. Vor diesem Hintergrund wurden in der Studie EFBI (Einstellungen von FSJler*innen zu Behinderung und Inklusion) N = 538 Freiwillige zu Beginn, in der Mitte und am Ende ihrer Teilnahme am Freiwilligen Sozialen Jahr standardisiert befragt. Im vorliegenden Beitrag werden behinderungsbezogene Einstellungsentwicklungen mithilfe latenter Wachstumskurvenmodelle analysiert und Zusammenhänge mit relevanten personen- und kontextbezogenen Faktoren geprüft. Die Befunde weisen auf spezifische Subgruppen hin, die sich in Bezug auf ihre behinderungsbezogenen Einstellungen systematisch unterscheiden. Im Verlauf des FSJ bleiben diese Einstellungsprofile jedoch weitgehend stabil. Positivere Einstellungen sind dabei insbesondere mit einer positiveren Bewertung des Kontakts mit Menschen mit Behinderung assoziiert. Die abschließende Diskussion fokussiert Implikationen für die Förderung positiver sozialer Einstellungen in informellen bzw. non-formalen Lernsettings.
The Evidence for Implantable Sacral Neuromodulation in Pediatric Voiding Dysfunction
Authors: Malallah Mariam , Cameron Anne , Sack Bryan 
Published: June 2024

Abstract
Purpose of Review
The purpose of this review is to evaluate the evidence regarding the efficacy and safety of implantable sacral neuromodulation (SNM) in pediatric patients with voiding dysfunction. The aim is to address the lack of substantial supporting data for SNM use in pediatric populations and provide insights into its potential as a treatment option.

Recent Findings
Recent research indicates that SNM can be an effective treatment for pediatric voiding dysfunction when conventional therapies fail. A systematic review of eight studies published between 2008 and 2021, involving 427 pediatric patients, revealed promising outcomes. These included a 68% improvement rate in urinary symptoms, with 39% experiencing complete resolution. Urodynamic improvements were also noted, with reductions in detrusor pressure, uninhibited detrusor contractions, and postvoid residual volume. However, complications such as lead issues, device migration or erosion, pain, and IPG replacement were observed in a notable percentage of cases, necessitating reoperation in some instances.

Summary
In conclusion, implantable SNM emerges as a potentially effective treatment for pediatric voiding dysfunction, improving urinary symptoms and quality of life. However, the presence of complications underscores the importance of careful risk-benefit assessment for individual patients. Further research is warranted to address varying success rates and complications, emphasizing the need for improved trial quality in this field. The findings of this review highlight the potential impact of SNM in pediatric populations and underscore the need for continued investigation and refinement of this therapeutic approach.
Exploring CCR5 + T regulatory cell subset dysfunction in type 1 diabetes patients: implications for immune regulation
Authors: Urszula Ławrynowicz , Ulana Juhas , Bartosz Słomiński , Maja Okońska , Małgorzata Myśliwiec , Monika Ryba-Stanisławowska 
Published: June 2024

AbstractT regulatory lymphocytes (Treg) expressing CCR5 exhibit strong suppression activity in various autoimmune disorders. However, there remains a lack of comprehensive understanding regarding their involvement in the development of type 1 diabetes (T1D). In this study, we examined the role of the CCR5/CCL5 axis in regulating inflammatory response and its impact on regulatory T cells in type 1 diabetes (T1D). We hypothesize that dysregulation of the CCR5/CCL5 axis contributes to the development and progression of T1D through modulation of Treg-dependent immune responses. We analyzed the expression levels of CCR5 on Tregs isolated from individuals with T1D, as well as the plasma concentration of its main ligands. We found that Tregs from T1D patients exhibited decreased expression of CCR5 compared to healthy controls. Additionally, we observed a correlation between the expression levels of CCR5 on Tregs and their immunosuppressive function in T1D patients. Our results indicate the impaired migratory capacity of CCR5 + Tregs, suggesting a possible link between the dysregulation of the CCR5/CCL5 axis and impaired immune regulation in T1D. In line with previous studies, our findings support the notion that dysregulation of the CCR5/CCL5 axis contributes to the development and progression of type 1 diabetes (T1D) by modulating Treg-dependent immune responses. The decreased expression of CCR5 on Tregs in T1D patients suggests a potential impairment in the migratory capacity of these cells, which could compromise their ability to suppress autoreactive T cells and maintain immune homeostasis. Furthermore, our study highlights the importance of CCR5 as a biomarker for identifying dysfunctional Tregs in T1D.
Revolutionizing cultural heritage preservation: an innovative IoT-based framework for protecting historical buildings
Authors: Casillo Mario , Colace Francesco , Gaeta Rosario , Lorusso Angelo , Santaniello Domenico , Valentino Carmine 
Published: June 2024

AbstractItaly offers a cultural heritage of considerable value that needs to be protected. Indeed, natural deterioration linked to the passage of time affects ancient artifacts and buildings. Sometimes, the deterioration compromises the functionality of cultural assets, pushing them toward decay. In this scenario, effective intervention seems impossible on the various critical points because of the wide variability of factors involved and the wide range of possible treatments. However, the spread of low-cost technologies has led to the possibility of having different devices and sensors able to communicate and interact with each other and humans: the Internet of Things (IoT). In this scenario, the IoT paradigm makes it possible to map reality by defining a coherent virtual representation (Digital Twin), which could help preserve Cultural Heritage. This work introduces an IoT-based system combining monitoring, predictive maintenance, and decision-making regarding the implementable interventions for protecting cultural heritage buildings. For this purpose, deep and machine learning techniques allow for the detection and classification of damages on specific materials. The experimental phase consists of two phases: the first aims to evaluate the accuracy of the proposed architecture, and the second exploits a prototype capable of interacting with expert users. The results of the experimental campaign are promising.
Geometric Description of Some Loewner Chains with Infinitely Many Slits
Authors: Theodosiadis Eleftherios K. , Zarvalis Konstantinos 
Published: June 2024

AbstractWe study the chordal Loewner equation associated with certain driving functions that produce infinitely many slits. Specifically, for a choice of a sequence of positive numbers $$(b_n)_{n\ge 1}$$

(

b
n

)

n
≥
1

and points of the real line $$(k_n)_{n\ge 1}$$

(

k
n

)

n
≥
1

, we explicitily solve the Loewner PDE $$\begin{aligned} \dfrac{\partial f}{\partial t}(z,t)=-f'(z,t)\sum _{n=1}^{+\infty }\dfrac{2b_n}{z-k_n\sqrt{1-t}} \end{aligned}$$

∂
f

∂
t

(
z
,
t
)

=
-

f
′

(
z
,
t
)

∑

n
=
1

+
∞

2

b
n

z
-

k
n

1
-
t

in $$\mathbb {H}\times [0,1)$$

H
×
[
0
,
1
)

. Using techniques involving the harmonic measure, we analyze the geometric behaviour of its solutions, as $$t\rightarrow 1^-$$

t
→

1
-

.
OTUD7B knockdown inhibits proliferation and autophagy through AKT/mTOR signaling pathway in human prostate cancer cell
Authors: Kim Yae Ji , Lee Hui Ju , Kim Kyung Hyun , Cho Sung Pil , Jung Ju Young 
Published: June 2024

AbstractProstate cancer (PCa) is the second leading disease of cancer-related death in men around the world, and it is almost impossible to treat advanced PCa. OTUD7B is a member of the deubiquitinase family that undergoes a post-translational transformation process, which is essential for cell stability and signaling and is known to play a critical role in cancer. However, its role in PCa has not been discovered. The aim of the study was to investigate the expression and mechanism of OTUD7B in PCa cells. According to the database, high OTUD7B expression showed a poor prognosis. Therefore, we downregulated OTUD7B using siRNA and confirmed the role of OTUD7B in PC3 prostate cancer cells. OTUD7B knockdown effectively induced apoptosis and inhibited the proliferation in PC3 cells. OTUD7B knockdown inhibited autophagy through AKT/mTOR signaling. We also confirmed the relationship between AKT/mTOR signaling and autophagy through rapamycin, an mTOR inhibitor. Taken together, OTUD7B promotes the proliferation, and autophagy, and inhibits apoptosis of prostate cancer cells via the AKT/mTOR signaling pathway.
Reporting Only the Good News but Not the Bad? Mechanism of Negative Performance Feedback
Authors: Li Qiufang , Xia Hui 
Published: June 2024

AbstractThe phenomenon of supervisors ignoring or over-implementing negative performance feedback exists in the work environment. Unlike the view on the negative role of negative performance feedback, existing research also suggests that negative performance feedback can produce a facilitating effect. In this study, a theoretical model was constructed based on the feedback intervention theory to explore the mechanism of negative performance feedback from supervisors on the innovative behaviors of employees in light of the influence of regulatory focus on error handling ability. The results of this study show that employees with a high promotion or prevention focus choose to enhance their error handling ability in the face of negative performance feedback from supervisors, which in turn positively affects their innovative behaviors. This study not only expands the field of research on negative performance feedback and innovative behaviors, but also has important implications for supervisors to take measures to improve the ability and competitiveness of employees.
Penicillin removal from the aqueous environment based on AOPs/challenges and outlook. A review
Authors: Goodarzi Shima , Torabideh Masoomeh , Parsaseresht Gholamreza , Abdipour Hossein , Kamani Hossein , Zomorrodi Jangaee Tayebe 
Published: June 2024

AbstractToday, the deterioration of water quality is still a big concern among researchers, whose essential strategy is to develop water purification processes. The presence of contamination of emerging concerns has become a challenging issue, their toxicity, persistence in the aquatic environment, and their mass accumulation at low concentrations have had adverse effects on human health and aquatic organisms. Biological disposal or improper disposal, these pollutants cause serious damage to the population of non-target groups. Penicillin is a broad-spectrum group of beta-lactam antibiotics that has caused concerns for human health and the environment due to its slow decomposition in water sources. This review article focuses on the application of advanced oxidation processes to eliminate these antibiotics. Several studies have investigated the effects of different parameters on species with both ultraviolet and non-ultraviolet light. The results have been promising, with an average efficiency above 80% for these processes. Despite the limitations of various methods, the knowledge gap in future studies has been addressed by proposing the use of Fenton, ultrasound method and Integrated processes like Synergistic Remediation-Advanced Oxidation Processes.
Deep Learning-Based Automated Analysis of NK Cell Cytotoxicity in Single Cancer Cell Arrays
Authors: Moon Dowon , Kim Seong-Eun , Wang Chuangqi , Lee Kwonmoo , Doh Junsang 
Published: June 2024

AbstractThe cytotoxicity assay of immune cells based on live cell imaging offers comprehensive information at the single cell-level information, but the data acquisition and analysis are labor-intensive. To overcome this limitation, we previously developed single cancer cell arrays that immobilize cancer cells in microwells as single cell arrays, thus allow high-throughput data acquisition. In this study, we utilize deep learning to automatically analyze NK cell cytotoxicity in the context of single cancer cell arrays. Defined cancer cell position and the separation of NK cells and cancer cells along distinct optical planes facilitate segmentation and classification by deep learning. Various deep learning models are evaluated to determine the most appropriate model. The results of the deep learning-based automated data analysis are consistent with those of the previous manual analysis. The integration of the microwell platform and deep learning would present new opportunities for the analysis of cell–cell interactions.
Characterising Parent-Appeal Marketing on Foods for Children: A Scoping Review
Authors: Chung Alexandra , Hatzikiriakidis Kostas , Martino Florentine , Skouteris Helen 
Published: June 2024

Abstract
Purpose of Review
This scoping review examines current evidence on parent-appeal marketing on the front-of-pack of food products for children and the impacts on parents’ perceptions, intentions, and behaviours.

Recent Findings
Thirteen relevant studies were identified. Marketing features on packages of foods for children that appealed to parents include health claims, nutrition claims, non-nutrient claims such as 'natural', healthy-looking product images, images of healthy ingredients, and celebrity endorsements. At the same time, parents were wary of front-of-pack marketing and find it confusing, deceptive, and misleading. Child-appeal marketing features such as cartoon characters and bright colours gave parents the perception that products were unhealthy.

Summary
Overall, this scoping review offers important insights into the types of front-of-pack marketing that appeal to parents and offers an inventory of parent-appeal marketing features. These findings support the design and implementation of policies that aim to reduce commercial influences on children’s diets through stronger regulation of marketing of foods for children.