bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global perceptions of state apologies for human rights violations
Authors: Schaafsma Juliette , de Groot Marlies , Sagherian‐Dickey Thia 
Published: August 2024

AbstractState apologies for human rights violations are often seen as a key mechanism in reconciliation processes. Nevertheless, they are often contested as well and have not been embraced equally by countries around the world. This raises questions about their universal value and potential to address or redress past harmdoing by countries. In a study across 33 countries (n = 11,023), we found that people around the world consider apologies by states for human rights violations to be reasonably important but tend to be less supportive of the idea that their own country should apologize for past harmdoing. We found that this discrepancy was amplified in countries with stronger honour norms and a stronger collective sense of victim– rather than perpetratorhood. Moving beyond the decontextualized approach that has prevailed in previous psychological research on this topic, our findings show that people's attitudes towards apologies by their country do not exist in a cultural and social vacuum but depend on the extent to which the broader context affords a critical reflection on past harmdoing. As such, they help explain why some countries have been reluctant to offer apologies, and why such gestures may also be more controversial in some contexts than in others.
The contribution and impact of shallow water platform as a potential source area on siliceous submarine fans
Authors: Zheng Xiaobo , Zhu Hongtao , Liu Qianghu , Zeng Zhiwei , Sun Zhongheng , Fan Caiwei 
Published: August 2024

AbstractThe shelf‐margin deltas are the primary ‘sources’ of interest in siliceous submarine fan source‐to‐sink systems. However, less has yet to be discovered about the roles and effects of the shallow water platform situated on continental slopes. Using the Miocene sediments of the Ledong‐Lingshui Sag in the western part of the Qiongdongnan Basin (QDNB), this paper studies the YC35 coarse‐grained submarine fan that developed in the Meishan Formation (Fm.). The material sources, depositional characteristics, and developmental mechanisms of this fan were investigated. The restored palaeogeomorphology, based on high‐resolution 3D seismic data, shows that a shallow water platform exists. According to geochemical palaeoenvironmental data, the shallow water platform was ideal for forming carbonate deposits in the Meishan Fm., owing to the warm and humid palaeoclimate and the shifting trend in palaeowater depth. Based on the combined source tracing of heavy minerals, coherence slices, and seismic profiles, the shallow water platform and the Ningyuan River source on Hainan Island contributed to the YC35 coarse‐grained submarine fan. Compared to submarine fans formed during different periods, coarse‐grained fan stands out due to its distinct sedimentary structure, rock composition, and microlithological characteristics. Aside from not following the usual Bowmar sequence, there is an excess of gravel and no clear bedding or lamination. A large number of rock fragments, mostly granite and sedimentary rock (carbonatite), make up the rock composition. According to these results, the shallow water platform significantly affects submarine fan material composition. In addition, the attribute slice based on the root mean square reveals that shallow water platforms moderate peripheral deposition. We attribute the development and proximal supply of the shallow water platform to diapirism and forced regression. Our research provides novel insights and comprehension into the investigation of submarine fan sedimentary systems.
Hyperglycemia‐induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis
Authors: Li Yongchang , Kong Erliang , Ding Ruifeng , Chu Ruitong , Lu Jinfang , Deng Mengqiu , Hua Tong , Yang Mei , Wang Haowei , Chen Dashuang , Song Honghao , Wei Huawei , Zhang Ping , Han Chaofeng , Yuan Hongbin 
Published: August 2024

AbstractBackgroundHyperglycemia‐induced neuroinflammation significantly contributes to diabetic neuropathic pain (DNP), but the underlying mechanisms remain unclear.ObjectiveTo investigate the role of Sirt3, a mitochondrial deacetylase, in hyperglycemia‐induced neuroinflammation and DNP and to explore potential therapeutic interventions.Method and ResultsHere, we found that Sirt3 was downregulated in spinal dorsal horn (SDH) of diabetic mice by RNA‐sequencing, which was further confirmed at the mRNA and protein level. Sirt3 deficiency exacerbated hyperglycemia‐induced neuroinflammation and DNP by enhancing microglial aerobic glycolysis in vivo and in vitro. Overexpression of Sirt3 in microglia alleviated inflammation by reducing aerobic glycolysis. Mechanistically, high‐glucose stimulation activated Akt, which phosphorylates and inactivates FoxO1. The inactivation of FoxO1 diminished the transcription of Sirt3. Besides that, we also found that hyperglycemia induced Sirt3 degradation via the mitophagy‐lysosomal pathway. Blocking Akt activation by GSK69093 or metformin rescued the degradation of Sirt3 protein and transcription inhibition of Sirt3 mRNA, which substantially diminished hyperglycemia‐induced inflammation. Metformin in vivo treatment alleviated neuroinflammation and diabetic neuropathic pain by rescuing hyperglycemia‐induced Sirt3 downregulation.ConclusionHyperglycemia induces metabolic reprogramming and inflammatory activation in microglia through the regulation of Sirt3 transcription and degradation. This novel mechanism identifies Sirt3 as a potential drug target for treating DNP.
Evaluation of neuroretina following i.v. or intra‐CSF AAV9 gene replacement in mice with MPS IIIA, a childhood dementia
Authors: Beard Helen , Winner Leanne , Shoubridge Andrew , Parkinson‐Lawrence Emma , Lau Adeline A. , Mubarokah Siti N. , Lance Tabitha‐Rose , King Barbara , Scott William , Snel Marten F. , Trim Paul J. , Hemsley Kim M. 
Published: August 2024

AbstractBackgroundSanfilippo syndrome (mucopolysaccharidosis type IIIA; MPS IIIA) is a childhood dementia caused by inherited mutations in the sulfamidase gene. At present, there is no treatment and children with classical disease generally die in their late teens. Intravenous or intra‐cerebrospinal fluid (CSF) injection of AAV9‐gene replacement is being examined in human clinical trials; evaluation of the impact on brain disease is an intense focus; however, MPS IIIA patients also experience profound, progressive photoreceptor loss, leading to night blindness.AimTo compare the relative efficacy of the two therapeutic approaches on retinal degeneration in MPS IIIA mice.MethodsNeonatal mice received i.v. or intra‐CSF AAV9‐sulfamidase or vehicle and after 20 weeks, biochemical and histological evaluation of neuroretina integrity was carried out.ResultsBoth treatments improved central retinal thickness; however, in peripheral retina, outer nuclear layer thickness and photoreceptor cell length were only significantly improved by i.v. gene replacement. Further, normalization of endo‐lysosomal compartment size and microglial morphology was only observed following intravenous gene delivery.ConclusionsConfirmatory studies are needed in adult mice; however, these data indicate that i.v. AAV9‐sulfamidase infusion leads to superior outcomes in neuroretina, and cerebrospinal fluid‐delivered AAV9 may need to be supplemented with another therapeutic approach for optimal patient quality of life.
Motivating government on threatened species through electoral systems
Authors: Kindler Gareth S. , Kusmanoff Alexander M. , Kearney Stephen , Ward Michelle , Fuller Richard A. , Lloyd Thomas J. , Bekessy Sarah A. , Gregg Emily A. , Stewart Romola , Watson James E. M. 
Published: August 2024

AbstractMany of the proposed solutions to the global biodiversity crisis rely on national governments to act. The conservation movement needs to motivate governments or face an ongoing extinction crisis. Here we explore how linking biodiversity to electoral systems may assist in motivating government action. Using Australia as a case study, we analyze the intersection of 151 electoral districts and 1651 threatened species. We show all districts contain at least 14 threatened species. Half of the species analyzed (n = 801, 49%) are confined to one district (n = 44), with 1345 (81%) species intersecting with less than five. This geographical information shows that alongside local social and economic issues, the threatened species crisis can be made relevant to all Australian elected representatives. Locally relevant information can encourage integration of species needs into the scope of political representation. As such, linking biodiversity to political geography offers a potential pathway to creating transformative change.
Cutaneous Rosai–Dorfman disease with MAP2K1 mutation, initially mimicking an infection with parasitized histiocytes
Authors: Gillam Joseph , Desai Ruchi , Louie Raphael J. , Turner Scott A. , Wang Grace Y. , Diaz‐Perez Julio A. , Mochel Mark C. 
Published: August 2024

AbstractRarely, Rosai–Dorfman disease (RDD) manifests exclusively in the skin, typically as nodules on the trunk and extremities. Recognition of characteristic histopathologic features enables diagnosis of RDD. A 55‐year‐old female presented with a 7‐year history of cutaneous nodules involving the trunk and extremities. A prior skin biopsy specimen at a different institution had demonstrated a dense dermal lymphohistiocytic infiltrate with histiocytes containing GMS+ forms, favored to represent cryptococcal organisms, with a differential diagnosis including other infections with parasitized histiocytes. Despite antibiotic therapy, lesions persisted. After a presentation to our institution, a biopsy specimen showed a diffuse infiltrate, including histiocytes with voluminous pale cytoplasm with focal emperipolesis of inflammatory cells and S100 immunohistochemical positivity. Clinical and radiologic examinations did not identify significant extracutaneous involvement. A genetic study performed on the biopsy specimen identified a K57Q mutation of MAP2K1. The presence of this mutation correlated with prior reports of MAP2K1 mutation in classic RDD, thereby supporting our histopathologic diagnosis of RDD over an infectious process and further illuminating options for targeted therapies. At 3‐year follow‐up, the patient has been managed with a course of systemic corticosteroids and excision of bothersome lesions. Consideration of systemic therapy is ongoing.
Data‐driven inventory forecasting in periodic‐review inventory systems adjusted with a fill rate requirement
Authors: Bruzda Joanna , Abbasi Babak , Urbańczyk Tomasz 
Published: August 2024

AbstractWe propose an integrated forecasting and optimization framework for base stock decisions in periodic‐review inventory systems subject to requirements for these systems' infinite‐horizon fill rates as agreed service levels. We provide a detailed discussion of the conditions necessary for the uniqueness of the required optimal solutions, examine some properties of our data‐driven computational procedure, and address the task of directly modeling base stock levels with the help of chosen semiparametric nonlinear dynamic models. To demonstrate the effectiveness of our strategy, we evaluate it on real data sets, finding that it achieves fill rates close to the target values and low implicit inventory costs. Our empirical assessment also highlights the usefulness of generalized autoregressive score (GAS) models for inventory planning based on medium‐sized historical demand samples. These models can be recommended for applications with nominal fill rates of 90–95%, but also for careful so‐called “focus forecasting” when required service levels are as high as 99–99.9%.
Social framing effects in leadership by example: Preferences or beliefs?
Authors: Cartwright Edward , Drouvelis Michalis 
Published: August 2024

AbstractWe study the impact of framing on leading‐by‐example. Our 2 × 2 design consists of group level frames (Wall Street vs. Community) and individual level frames (First/Second Movers vs. Leader/Followers). We report on two studies where we elicit participants' beliefs allowing us to evaluate whether framing effects are driven by beliefs or preferences. Across both studies, average contributions are significantly lower in the Community—First Mover frame. This is primarily because leaders contribute less, pulling down followers' contributions. We find that contributions are strongly related to first order and second order beliefs but framing effects remain once we control for beliefs.
Morphological classification of radial glia–like cells in the postnatal mouse subventricular zone
Authors: Yoshida Ryota , Mori Tetsuji 
Published: August 2024

AbstractThe subventricular zone (SVZ) is one of the neurogenic regions of the adult mammalian brain. Neural stem cells (NSCs) in the SVZ have certain key features: they express glial fibrillary acidic protein (GFAP), proliferate slowly, have a radial glia–like (RG‐L) morphology, and are in contact with the cerebrospinal fluid (CSF). NSCs have been isolated by FACS to analyse them, but their morphology has not been systematically examined. To address this knowledge gap, we sparsely labelled RG‐L cells in the SVZ of neonatal mice by introducing via electroporation a plasmid expressing fluorescent protein under the control of the GFAP promoter. We then classified RG‐L cells into three types (RG‐L1, 2, and 3) based on their morphologies. RG‐L1 cells had a basal process with some branches and numerous fine processes. RG‐L2 cells had a basal process, but fewer branches and fine processes than RG‐L1 cells. RG‐L3 cells had one basal process that was almost free of branches and fine processes. Importantly, regardless of the cell type, about half of their somata resided on the basal side of the SVZ. Based on changes in their proportions during postnatal development and their expression of GFAP and cell proliferation markers at the adult stage, we speculated that NSCs change their morphologies during development/maturation and not all NSCs must always be in the apical SVZ or in contact with the CSF. Our results indicate that in addition to expression of markers for NSCs, the morphology is a critical feature to identify NSCs.
Strategic change: A systematic review, synthesis, and a future research agenda
Authors: Acciarini Chiara , Boccardelli Paolo , Peruffo Enzo 
Published: August 2024

AbstractStrategic change (SC) is widely addressed in the scholarly domain and continues to gain momentum in the rapidly evolving landscape of today's business world. What are the antecedents, processes, outcomes, and who are the actors in SC? We address this question through a systematic review of SC that suggests new avenues for management research and offers important reflections for practice regarding: (i) the main factors responsible for determining SC; (ii) the principal actions and methods adopted to implement SC; (iii) the main effects associated with SC; and (iv) the actors responsible for directing SC. By synthesizing and integrating the extant research, this review develops a framework of types of antecedents (i.e., internal and external), processes (i.e., initiation, implementation, sensemaking, and sensegiving), outcomes (i.e., adaptive and disruptive), and actors (i.e., chief executive officer [CEO], board of directors, top management team [TMT], and collective leadership) of SC. Our review culminates in the development of a series potential avenues for future research.
Unfolding crowd‐based accountability of a charity fund during the war
Authors: Melnyk Valeriia , Iermolenko Olga , Cordery Carolyn 
Published: August 2024

AbstractCharity organizations’ accountability is crucial for their work and existence, as these organizations depend on continuous public donations. Meeting the needs of all stakeholders places additional challenges on charities and forces them to use different ways/forms of accountability. Recently, social media (SM) has been extensively used for both charity fundraising and reporting/accountability. With few exceptions, the current literature describes this process as rather one‐sided—where charity organizations pursue their agendas without engaging with or responding to crowds accessing their SM. This research uses netnographic and interview data to investigate how public SM engagement reconfigures a charity's accountability during wartime. We utilize the case of a significant Ukrainian charity fund that gathered over USD 110 million in donations in 2022 via SM to meet the needs of that country's army as well as victims of Russia's War in Ukraine. SM enabled crowds to question and critique the fund's accountability, generating a crowd‐based accountability dialog which required the charity to respond. Consequently, the charity evolved dialogic accountability processes between the crowd, the fund and its celebrity founder, the latter playing a mediating role in the fund's dialog with the crowd. This study adds to the literature on online publics and crowd‐based accountability as dialog. A particularly significant facet of this study concerns the highly sensitized context where, despite the exigencies faced, donors’ expectations of accountability remain high. Charity organizations, other nongovernmental organizations and governments can learn from this use of SM as a crowd‐based accountability tool to enable real dialog during significant crises (in our case, Russia's War in Ukraine).
Fatigue and corrosion‐fatigue behavior of the β‐metastable Ti‐5Al‐5Mo‐5V‐3Cr alloy processed by laser powder bed fusion
Authors: Alcântara Erika Gabriele Alves , Meinke Reinhard , Selve Sören , Kaya Ali Can , Fleck Claudia 
Published: August 2024

AbstractWe performed rotating bending tests and axial (tension‐compression) load‐increase and constant amplitude high‐cycle fatigue tests in air and Hanks' balanced salt solution (HBSS) on the β‐metastable titanium alloy Ti‐5Al‐5Mo‐5V‐3Cr, processed by laser powder bed fusion (LPBF‐M), solution‐treated and aged, and shot‐peened. Rotating bending loading in air revealed a strong influence of process‐induced flaws on fatigue endurance. Especially in the high‐cycle fatigue range and the transition region, the stochastic distribution of the flaws and flaw sizes led to a high scatter of the number of cycles to failure. The axial load‐increase tests yielded a good fatigue life estimation, with a negligible difference between air and HBSS. The cyclic deformation behavior in HBSS was also strongly influenced by the local microstructure and defect distribution, and, thus, by crack formation and propagation. Plastic deformation and microcrack growth interact, and their relative amount resulted in different progressions of the plastic strain amplitude over the number of cycles for different specimens. Changes in the free corrosion potential and the corrosion current were highly sensitive indicators for fatigue‐induced damage on the rough surfaces, which was correlated to the microscopic examination, fracture surface features, and the fatigue crack development.
Interspecies differences and lake‐specificity in the δ13C and δ18O signatures of charophyte carbonate encrustations
Authors: Pełechaty Mariusz , Pronin Eugeniusz , Pukacz Andrzej , Apolinarska Karina 
Published: August 2024

Abstract

This study identifies the relationships between the δ13C and δ18O signatures of extant charophyte carbonates (δ13CCARB and δ18OCARB) and the δ13C of dissolved inorganic carbon and δ18O of water (δ13CDIC and δ18OWATER), respectively, and the structure of charophyte beds and the physico‐chemical properties of the ambient water. Inter‐ and intra‐specific differences and lake‐related variability are assessed.

Four morphologically different charophyte species (Nitellopsis obtusa, Chara tomentosa, Chara rudis, Chara contraria) were studied in four charophyte‐dominated lakes (Chara‐lakes) in Central Europe. A wide distribution of the species in calcium‐rich freshwater lakes, where they form extensive underwater beds and contribute to the deposition of calcareous sediments, makes the study representative of Chara‐lakes. Charophytes and water above them were sampled monthly (June–September 2008) at permanent study sites. Additionally, three comparative macrophyte‐free pelagic sites were sampled in each lake.

For all the charophytes studied, there was a greater variation in the δ13C and δ18O values of the encrustations than of the ambient and pelagic waters. Except for N. obtusa and C. tomentosa, the species differed significantly in the δ13CCARB values. The encrustations were enriched in 13C compared to water DIC. Chara tomentosa encrustations were significantly depleted in 18O compared to N. obtusa and C. contraria. In contrast to Chara species, N. obtusa encrustation was 18O‐enriched compared to surrounding water. The largest isotope differences between carbonate encrustations and surrounding water were found for C. rudis.

Considering the δ13CCARB versus δ13CDIC values, only slender species (i.e. N. obtusa and C. contraria) precipitated encrustations close to isotopic equilibrium with water DIC. Based on theoretical δ18OCALCULATED and measured δ18OCARB values, only C. tomentosa precipitated encrustation in equilibrium with the δ18OWATER.

Using redundancy analysis, the δ13CCARB values positively correlated with the δ13CDIC and δ18OWATER values and the percent volume of water inhabited by plants. The depth of sites, water mineralisation, alkalinity and fertility were inversely correlated with the δ13CCARB. The redundancy analysis revealed a clear division of samples into species and lakes; lakes were especially distinct.

We postulate that the stable C and O isotope compositions of charophyte encrustations are lake‐ rather than species‐specific and that the isotopic signatures of charophyte carbonates are representative of the entire lake epilimnion, not just the vegetated littoral zone. Furthermore, the isotopic signal of bulk sediment can provide environmental information that is as useful as species‐specific isotope values.
Drivers of transnational administrative coordination on super‐wicked policy issues: The role of institutional homophily
Authors: Carelli Daniel 
Published: August 2024

AbstractIn European governance, transnational administrative networks have become crucial for addressing complex cross‐border challenges, supplementing formal harmonization efforts with informal collaborative mechanisms. However, little attention has been given to their role in addressing super‐wicked policy problems, where formal structures and political prioritization are lacking despite pressing temporal deadlines and substantial costs for future generations. This study investigates the drivers of administrative coordination in Europe within such contexts, using the case of antimicrobial resistance as a case study. Employing a mixed‐method approach, including Logistic Regression Quadratic Assignment Procedure and a qualitative analysis based on originally collected expert survey and interview data, the research uncovers a notable trend: countries with similar levels of institutional quality are four times more likely to establish connections. This selective coordination dynamic is shaped by domestic circumstances, politico‐administrative considerations, and the pursuit of pragmatic, implementable policy solutions, with important implications for the ongoing struggle against antibiotic resistance.