bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Intraplaque Hemorrhage and Acute Infarction in Patients With Basilar Artery Plaque
Authors: Yu Jin Hee , Kwak Hyo Sung , Chung Gyung Ho , Hwang Seung Bae , Park Mi Sung , Park Seong Hoon 
Published: August 2015

Background and Purpose—
High-resolution magnetic resonance imaging (HRMRI) is ideal for serial examination of diseased arterial walls because it is noninvasive and has superior capability of discriminating tissue characteristics. The aim of this study is to evaluate the prevalence and clinical relevance of intraplaque hemorrhage (IPH) in patients with basilar artery (BA) atherosclerosis using HRMRI.

Methods—
We analyzed HRMRI and clinical data from 74 patients (45 symptomatic and 29 asymptomatic), all of whom had >50% BA stenosis. High-signal intensity within a BA plaque on magnetization-prepared rapid acquisition with gradient-echo was defined as an area with an intensity that was >150% of the signal from the adjacent muscle. The relationship between IPH within a BA plaque region and clinical presentation was analyzed.

Results—

Thirty patients were positive for IPH on HRMRI (42.3%, 24 symptomatic and 6 asymptomatic). Symptomatic lesions in the MR-positive IPH group were significantly more prevalent than in the MR-negative group (80.0% versus 48.8%;
P
<0.01). Also, MR-predicted IPH was significantly more prevalent in the high-grade stenosis group (
P
<0.001) than in the low-grade group. The relative risk of an acute focal stroke event among patients who were magnetization-prepared rapid acquisition with gradient-echo–positive for IPH compared with patients who were magnetization-prepared rapid acquisition with gradient-echo–negative was 1.64.

Conclusions––
IPH within a BA plaque region on HRMRI is highly prevalent and is associated with acute stroke.
PD-L1 Monoclonal Antibody Treats Ischemic Stroke by Controlling Central Nervous System Inflammation
Authors: Bodhankar Sheetal , Chen Yingxin , Lapato Andrew , Dotson Abby L. , Wang Jianming , Vandenbark Arthur A. , Saugstad Julie A. , Offner Halina 
Published: August 2015

Background and Purpose—
Both pathogenic and regulatory immune processes are involved in the middle cerebral artery occlusion (MCAO) model of experimental stroke, including interactions involving the programmed death 1 (PD-1) receptor and its 2 ligands, PD-L1 and PD-L2. Although PD-1 reduced stroke severity, PD-L1 and PD-L2 appeared to play pathogenic roles, suggesting the use of anti-PD-L monoclonal antibody therapy for MCAO.

Methods—
Male C57BL/6 mice were treated with a single dose of anti-PD-L1 monoclonal antibody 4 hours after MCAO and evaluated for clinical, histological and immunologic changes after 96 hours of reperfusion.

Results—

Blockade of the PD-L1 checkpoint using a single injection of 200 μg anti-PD-L1 monoclonal antibody given intravenously 4 hours after occlusion significantly reduced MCAO infarct volumes and improved neurological outcomes after 96 hours of reperfusion. Treatment partially reversed splenic atrophy and decreased central nervous system infiltrating immune cells concomitant with enhanced appearance of CD8
+
regulatory T cells in the lesioned central nervous system hemisphere.

Conclusions—
This study demonstrates for the first time the beneficial therapeutic effects of PD-L1 checkpoint blockade on MCAO, thus validating proposed mechanisms obtained in our previous studies using PD-1- and PD-L-deficient mice. These results provide strong support for the use of available humanized anti-PD-L1 antibodies for treatment of human stroke subjects.
An Ensemble Approach to Investigate Tropical Cyclone Intensification in Sheared Environments. Part I: Katia (2011)
Authors: Rios-Berrios Rosimar , Torn Ryan D. , Davis Christopher A. 
Published: August 2015

Abstract
The mechanisms responsible for tropical cyclone (TC) intensification in the presence of moderate vertical shear magnitudes are not well understood. To investigate how TCs intensify in spite of moderate shear, this study employed a 96-member ensemble generated with the Advanced Hurricane Weather Research and Forecasting (AHW) Model. In this first part, AHW ensemble forecasts for TC Katia (2011) were evaluated when Katia was a weak tropical storm in an environment of 12 m s−1 easterly shear. The 5-day AHW forecasts for Katia were characterized by large variability in the intensity, presenting an opportunity to compare the underlying mechanisms between two subsets of members that predicted different intensity scenarios: intensification and weakening. The key difference between these two subsets was found in the lower-tropospheric moisture north of Katia (i.e., right-of-shear quadrant). With more water vapor in the lower troposphere, buoyant updrafts helped to moisten the midtroposphere and enhanced the likelihood of deep and organized convection in the subset that predicted intensification. This finding was validated with a vorticity budget, which showed that deep cyclonic vortex stretching and tilting contributed to spinning up the circulation after the midtroposphere had moistened. Sensitivity experiments, in which the initial conditions were perturbed, also demonstrated the importance of lower-tropospheric moisture, which suggests that moisture observations may help reduce uncertainty in forecasts of weak, sheared tropical storms.
Nonlinear Zonal Wind Response to ENSO in the CMIP5 Models: Roles of the Zonal and Meridional Shift of the ITCZ/SPCZ and the Simulated Climatological Precipitation*
Authors: Choi Kit-Yan , Vecchi Gabriel A. , Wittenberg Andrew T. 
Published: August 2015

Abstract
The observed equatorial Pacific zonal wind response during El Niño tends to be stronger than during La Niña. Most global coupled climate models in phase 5 of CMIP (CMIP5) exhibit such nonlinearity, although weaker than observed. The wind response nonlinearity can be reproduced by driving a linear shallow water atmospheric model with a model’s or the observed precipitation anomalies, which can be decomposed into two main components: the zonal and meridional redistribution of the climatological precipitation. Both redistributions contribute comparably to the total rainfall anomalies, whereas the zonal redistribution plays the dominant role in the zonal wind response. The meridional redistribution component plays an indirect role in the nonlinear wind response by limiting the zonal redistribution during La Niña and thus enhancing the nonlinearity in the wind response significantly. During La Niña, the poleward movement of the ITCZ/SPCZ reduces the equatorial zonal-mean precipitation available for the zonal redistribution and its resulting zonal wind response. Conversely, during El Niño, the equatorward movement of the ITCZ and SPCZ do not limit the zonal redistribution of precipitation. The linear equatorial zonal wind response to ENSO is found to have a significant linear correlation with the equatorial central Pacific climatological precipitation and SST among the CMIP5 models. However, no linear correlation is found between the nonlinear equatorial zonal wind response and the climatological precipitation.
Irritant‐Induced Paradoxical Vocal Fold Motion Disorder
Authors: Marcinow Anna M. , Thompson Jennifer , Forrest L. Arick , deSilva Brad W. 
Published: August 2015

ObjectivesTo review our experience with the diagnosis and treatment of irritant‐induced paradoxical vocal fold motion disorder (IPVFMD).Study DesignRetrospective chart review.SettingTertiary academic referral center.Subjects and MethodsThirty‐four cases that met IPVFMD criteria and 76 cases of non‐IPVFMD were selected from a database of patients with paradoxical vocal fold motion disorder—the diagnosis of which was made on the basis of flexible fiberoptic laryngoscopy and augmented by an odor challenge. Clinical charts were reviewed to document history of environmental allergies, pulmonary disease, gastroesophageal reflux, psychiatric disorder, fibromyalgia, tobacco use, alcohol use, dysphonia, cough, dysphagia, and treatment outcomes.ResultsThere were no statistical differences between the IPVFMD and non‐IPVFMD groups. Of the patients who were assigned and attended laryngeal control therapy, 13 (65%) reported improvement of symptoms. Symptom improvement increased to 100% in those patients who attended at least 2 laryngeal control therapy sessions.ConclusionsIPVFMD should be considered in patients presenting with respiratory symptoms after irritant exposure. Sensitivity of diagnosis can be improved via a standardized approach consisting of a careful history and physical examination, including laryngoscopy in the presence of triggers. Laryngeal control therapy is a well‐tolerated and effective method of managing IPVFMD.
Introduction to Special Collection: Women’s agency at work
Authors: Sayers Janet , Parker Jane , Douglas Julie , Ravenswood Katherine , Cooper Rae 
Published: August 2015

AbstractThis article introduces a Special Collection of four articles that highlight responses by working women collectively and individually to forces accelerated by the recent global crises. It draws out common themes from accounts of African women’s responses to harassment at work, of the links between union representation and pay equity in Brazil and South Africa and of Australian women’s quest for flexible and fair work/family arrangements. From these perspectives, the article sets out a five-point research agenda to help empower women’s collective and individual agency in response to working conditions shaped by global economic and social forces.
Intralesional injection treatment of hypertrophic scars and keloids: a systematic review regarding outcomes
Authors: Trisliana Perdanasari Aurelia , Torresetti Matteo , Grassetti Luca , Nicoli Fabio , Zhang Yi Xin , Dashti Talal , Di Benedetto Giovanni , Lazzeri Davide 
Published: August 2015

AbstractBackgroundThe aim of this review was to explore the existing body of literature focusing on the intralesional treatments of keloids and hypertrophic scars.MethodsA comprehensive systematic review of related articles was conducted across multiple databases. Article selection was limited to those published in the English language between 1950 and 2014. Search terms for the on-line research were “scar(s),” “keloid(s),” “hypertrophic,” “injection,” “intralesional,” and “treatment”.ResultsThe initial search returned 2548 published articles. After full text review, the final search yielded 11 articles that met inclusion criteria. A total of 14 patient samples in 11 articles were collected. The most frequent intralesional injection treatment studied was triamcinolone (n = 5), followed by bleomycin (n = 3), 5-fluorouracil (n = 2), verapamil (n = 2), cryosurgery, and collagenase. The scar height reduction for all but one study was demonstrated, with acceptable complication and recurrence rate. Only three articles reported a follow-up period longer than 18 months, and only two studies used standardized outcome criteria with a quantitative scale.ConclusionsAlthough many treatment options have already been described in the literature, there is no universally accepted treatment resulting in permanent hypertrophic or keloid scar ablation. The lack of adequately long-term powered randomized controlled trials does not permit to establish definitive conclusions with implications for routine clinical practice.Level of evidenceIII/Therapeutic
Potential mechanisms regulating pulmonary pathology in inflammatory bowel disease
Authors: Mateer Sean W , Maltby Steven , Marks Ellen , Foster Paul S , Horvat Jay C , Hansbro Philip M , Keely Simon 
Published: August 2015

AbstractInflammatory bowel disease is associated with a number of comorbidities that arise at extraintestinal sites, including the lung. Pulmonary manifestations reported in inflammatory bowel disease include bronchiectasis, chronic bronchitis and importantly, a range of subclinical respiratory abnormalities that are often overlooked in routine clinical evaluation. Whereas evidence for the pulmonary manifestations of Inflammatory bowel disease is increasing, little is known about the immunologic and physiologic mechanisms regulating cross-talk between the gut and lung during disease. This review examines reported lung involvement in Inflammatory bowel disease and discusses the possible immune pathways that underlie pulmonary pathologies. These mechanisms include dysfunctional immune-cell homing, systemic inflammation, and microbial dysbiosis; all of which may contribute to Inflammatory bowel disease-induced pulmonary inflammation. These mechanisms are discussed in the context of our current knowledge of the shared mucosal immune system and the immunology of Inflammatory bowel disease.
Electricity Trading and Negative Prices: Storage vs. Disposal
Authors: Zhou Yangfang (Helen) , Scheller-Wolf Alan , Secomandi Nicola , Smith Stephen 
Published: August 2015

Electricity cannot yet be stored on a large scale, but technological advances leading to cheaper and more efficient industrial batteries make grid-level storage of electricity surpluses a natural choice. Because electricity prices can be negative, it is unclear how the presence of negative prices might affect the storage policy structure known to be optimal when prices are only nonnegative, or even how important it is to consider negative prices when managing an industrial battery. For fast storage (a storage facility that can both be fully emptied and filled up in one decision period), we show analytically that negative prices can substantially alter the optimal storage policy structure, e.g., all else being equal, it can be optimal to empty an almost empty storage facility and fill up an almost full one. For more typical slow grid-level electricity storage, we numerically establish that ignoring negative prices could result in a considerable loss of value when negative prices occur more than 5% of the time. Negative prices raise another possibility: rather than storing surpluses, a merchant might buy negatively priced electricity surpluses and dispose of them, e.g., using load banks. We find that the value of such a disposal strategy is substantial, e.g., about $118 per kilowatt-year when negative prices occur 10% of the time, but smaller than that of the storage strategy, e.g., about $391 per kilowatt-year using a typical battery. However, devices for disposal are much cheaper than those for storage. Our results thus have ramifications for merchants as well as policy makers. This paper was accepted by Serguei Netessine, operations management.
Assessment of stroke survivors on an inpatient rehabilitation unit
Authors: Gurr Birgit , Dendle Jac 
Published: August 2015

Background:Following a stroke, individuals often experience substantial difficulties, including speech and language problems, mobility, cognitive and emotional problems. Clinical guidelines for stroke care highlight the importance of assessing and monitoring mood and cognitive functioning of stroke survivors, in order to support the individual and guide multidisciplinary teams in holistic rehabilitation. This paper presents how psychological wellbeing assessments combine mood and cognitive screening and inform nursing and rehabilitation activities.Aim:Psychological wellbeing assessments were evaluated in view of their suitability for meeting the professional and stroke standards for mood and cognitive assessments. It was aimed to present how such assessments inform nursing care, individual rehabilitation programmes and discharge arrangements.Methods:A total of 83 patients were assessed with mood and cognitive screening procedures. As many as 75 patients had a diagnosis of ischaemic stroke and eight patients experienced an intracerebral haemorrhage. All patients were assessed on an inpatient stroke rehabilitation unit. More than half of the patients (43) were male, while 40 were female. The average age was 71 years with a range from 23–96 years. Results: Mood assessments were carried out with 76 patients. Among these, 14 patients presented borderline clinical mood symptoms and six patients showed significant psychological disturbances. More than three-quarters of patients (65) completed cognitive assessments. Outcomes informed the clinical team about their baseline functions, capacity issues and the data contributed to specific cognitive skills training and functional occupational therapy programmes.Conclusions:Psychological wellbeing assessments offer opportunities for nursing and multidisciplinary teams to cover a range of mood and cognitive issues. Combined mood and cognitive screenings are practical and effective procedures helping to meet service standards and requirements.
FERREIRA, J. R. Eurípides: As suplicantes. 1. ed. Porto Alegre: Movimento, 2012. 78 p. ISBN 978-85-7195-150-1
Authors: Salvador Evandro Luis 
Published: August 2015

Resenha de FERREIRA, J. R. Eurípides: As suplicantes. 1. ed. Porto Alegre: Movimento, 2012. 78 p. ISBN 978-85-7195-150-1
Computational evaluation of amplitude modulation for enhanced magnetic nanoparticle hyperthermia
Authors: Soetaert Frederik , Dupré Luc , Ivkov Robert , Crevecoeur Guillaume 
Published: August 2015

AbstractMagnetic nanoparticles (MNPs) can interact with alternating magnetic fields (AMFs) to deposit localized energy for hyperthermia treatment of cancer. Hyperthermia is useful in the context of multimodality treatments with radiation or chemotherapy to enhance disease control without increased toxicity. The unique attributes of heat deposition and transfer with MNPs have generated considerable attention and have been the focus of extensive investigations to elucidate mechanisms and optimize performance. Three-dimensional (3D) simulations are often conducted with the finite element method (FEM) using the Pennes’ bioheat equation. In the current study, the Pennes’ equation was modified to include a thermal damage-dependent perfusion profile to improve model predictions with respect to known physiological responses to tissue heating. A normal distribution of MNPs in a model liver tumor was combined with empirical nanoparticle heating data to calculate tumor temperature distributions and resulting survival fraction of cancer cells. In addition, calculated spatiotemporal temperature changes were compared among magnetic field amplitude modulations of a base 150-kHz sinusoidal waveform, specifically, no modulation, sinusoidal, rectangular, and triangular modulation. Complex relationships were observed between nanoparticle heating and cancer tissue damage when amplitude modulation and damage-related perfusion profiles were varied. These results are tantalizing and motivate further exploration of amplitude modulation as a means to enhance efficiency of and overcome technical challenges associated with magnetic nanoparticle hyperthermia (MNH).
Three-Dimensional CFD Simulation of a “Steam Water Spray” Retort Process for Food Vegetable Products
Authors: Mosna David , Vignali Giuseppe 
Published: August 2015

Abstract
This work aims at simulating a retort sterilization process of flexible packaging, performed in autoclave. ANSYS CFD© software has been used in this study to simulate the heat transfer inside the retort chamber. Flexible packaging filled with a pumpkin soup has been modelled. Three-dimensional (3D) geometrical configuration of the equipment has been designed and then simulated to evaluate the sterilization level achieved by each packaging inside the retort chamber. In particular, the internal temperature of the product situated in the cold spot of the chamber has been monitored during 5 min of the process (after reaching 85°C inside the product) in order to monitor the time/temperature trend. Experimental tests have been finally performed to validate the simulation model of heat exchange. The sterilization process takes place in a retort chamber by means of “overheated water sprayed” at 403 K and a pressure of 5 atm. Results show a good agreement between the simulated results and the real retort process and confirm the potential value of the simulation model to evaluate the process performance.
Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation syndrome and celiac disease in a 13-year-old girl: further evidence for autoimmunity?
Authors: Cemeroglu Ayse Pinar , Eng Donna S. , Most Laura A. , Stalsonburg Carrissa M. , Kleis Lora 
Published: August 2015

AbstractRapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation (ROHHAD) syndrome is a rare and potentially lethal disorder. The etiology is unclear but paraneoplastic syndrome and autoimmunity secondary to neural crest tumors have been considered, even in patients without any detectable tumor due to their tendency for spontaneous remission. We are presenting a 13-year-old girl with ROHHAD syndrome and celiac disease, which may suggest further evidence for immune-mediated etiology in the pathogenesis of ROHHAD syndrome.
Association between decreased plasma levels of soluble human leukocyte antigen-G and severe pre-eclampsia
Authors: He Yingdong , Chen Shi , Huang He , Chen Qian 
Published: August 2015

AbstractThe aim of this study was to investigate the levels of different isoforms of soluble human leukocyte antigen-G (sHLA-G) in maternal plasma during early and late pregnancy, and to investigate the expression of sHLA-G isoforms in women with early or late-onset severe preeclampsia.This prospective, nested, case-control study was performed in 24 early-onset severe preeclamptic, 34 late-onset severe preeclamptic, and 74 uncomplicated pregnant women. Plasma levels of sHLA-G1/5 were measured using ELISA.Plasma sHLA-G1 levels in women with late-onset severe preeclampsia were markedly lower compared with normal controls (median: 0 vs. 1.22 ng/mL) at the first trimester, and plasma sHLA-G1 levels in women with early-onset severe preeclampsia were markedly lower compared with normal controls at the second (median: 0 vs. 1.24 ng/mL) and third (median: 0 vs. 1.34 ng/mL) trimesters. There was no difference between the late-onset and early-onset groups at three trimesters. As for sHLA-G5, there was no difference in concentrations among the three groups at any time point. However, compared with controls, more women with early- or late-onset severe preeclampsia had undetectable sHLA-G5 levels in the first (71.4% and 76.2% vs. 14.1%), second (75.0% and 73.3% vs. 19.0%), and third (100.0% and 70.4% vs. 14.8%, respectively) trimester (all P<0.05). sHLA-G1 levels in the first (odds ratio [OR]=0.254, 95% confidence interval [CI]=0.109–0.591, P=0.010), second (OR=0.315, 95% CI=0.158–0.627, P=0.001), and third (OR=0.170, 95% CI=0.054–0.533, P=0.002) trimester was a risk factor for severe preeclampsia.Severe preeclampsia was associated with low/undetectable maternal plasma levels of sHLA-G. Low sHLA-G1 levels might be a risk marker for severe preeclampsia.
New distributional record of Chelemys megalonyx (Rodentia: Cricetidae) from the central valley of Chile, and some implications for its distribution and conservation
Authors: Bazán-León Enrique A. , Botero-Delgadillo Esteban , Venegas Cristóbal I. , Butler-Llanos Nasrim , Yáñez José L. , Torres-Mura Juan C. , Vásquez Rodrigo A. 
Published: August 2015

AbstractWe report a new locality for the rodent