bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transseptal antegrade transcatheter aortic valve replacement for patients with no other access approach—A contemporary experience
Authors: Cohen Mauricio G. , Singh Vikas , Martinez Claudia A. , O'Neill Brian P. , Alfonso Carlos E. , Martinezclark Pedro O. , Heldman Alan W. , O'Neill William W. 
Published: June 2013

ObjectiveTo assess the feasibility and outcomes in patients undergoing transvenous transseptal (TS) transcatheter aortic valve replacement (TAVR).BackgroundTS approach for TAVR was abandoned in favor of retrograde transfemoral, transaortic, or transapical approaches. TS TAVR may still be warranted in patients for whom no other approach is feasible.MethodsObservational consecutive case series at a single center, to evaluate technical outcomes in inoperable patients with aortic stenosis who had contraindications for other approaches and who underwent TAVR via a transvenous TS antegrade approach using the Edwards–Sapien (ES) valve.ResultsOver a 4‐month period, 9 patients underwent TS TAVR with 26 mm (n = 4) and 23 mm (n = 5) ES valves. Mean age was 84.5 ± 6.6 years and Society of Thoracic Surgeons predicted risk of mortality was 7.8 ± 2.8%. Specific contraindications for other access included iliofemoral arterial diameter <7 mm in 9 (100%), porcelain aorta in 6 (66%) patients, multiple (≥2) sternotomies in 2 (22%) patients, severe pulmonary disease in 3 (33%), extreme frailty in 1 (11%), spinal stenosis with impaired ability to rehabilitate postsurgery in 1 (11%) and apical left ventricular thrombus in 1 (11%) patient. Antegrade deployment of the ES prosthetic valve was technically feasible in 8 patients. Major bleeding occurred in 4 patients, two patients suffered acute kidney injury without need for dialysis and one patient required a permanent pacemaker. The median (25th, 75th percentiles) fluoroscopy time was 49 (34, 81) minutes and contrast volume was 150 (120, 225) ml. No patient had hemodynamically significant post‐TAVR aortic insufficiency nor damage to the mitral valve. At 6 months follow‐up, there were no cerebrovascular events or rehospitalizations and mean NYHA Class improved from 3.4 to 1.7.ConclusionsThe antegrade TS approach to TAVR is a technically feasible option for “no‐access” patients. Prospective assessment of the safety and efficacy of this approach in the current era warrants further study. © 2013 Wiley Periodicals, Inc.
The Glider registry
Authors: Secco Gioel Gabrio , Rittger Harald , Hoffmann Stefan , Richardt Gert , Abdel‐Wahab Mohamed , Reinecke Holger , Lotan Chaim , Werner Gerald , Sievert Horst , Foin Nicolas , Di Mario Carlo 
Published: June 2013

BackgroundProvisional stenting of the side‐branch (SB) is the universally accepted gold standard while there is still controversy on the usefulness of routine dilatation of the SB ostium. Recrossing the struts of a previously deployed stent with a wire and a balloon can prove challenging and is occasionally unsuccessful, mainly because the balloon tip hits a stent strut. This prospective multicenter international registry tested the crossing ability procedural results of a new‐dedicated ultrashort balloon specifically designed for side branch dilatation (Glider, TriReme Medical, Pleasanton, CA, USA).MethodsOne hundred and twenty five patients (for a total of 131 bifurcation lesions) were enrolled in the registry between January 2009 and May 2012. The Glider was used as first choice in alternative to conventional balloon (group I, 72%) or as bail‐out after unsuccessful previous attempt at crossing with small conventional low‐profile balloons (group II, 28%). Postprocedural coronary artery dissections and in‐hospital MACE (death, myocardial infarction and repeat revascularization) were assessed. Technical success was defined as the ability of the Glider to recross the struts of a previously deployed stent while procedural success was defined as less of residual 50% diameter stenosis at the origin of the SB with a final TIMI 3 and/or freedom from in‐hospital MACE.ResultsTechnical success was achieved, respectively, in 92% (group I), and 83% (group II). Clinical and angiographic procedural success was achieved in 98% of the lesions. In Group II, no other balloon of the same size could cross in cases where Glider could not. A total of 13 complications were observed, including nine ostial SB dissection four of which needed a second stent on the SB, one stent loss, two severe coronary spasms, and two by thrombus formation.ConclusionThe unique possibility offered by this short dedicated balloon to orientate its beveled tip provides an effective strategy for recrossing stent struts when conventional low profile balloons fail achieving greater SB ostial expansion thus reducing the incidence of strut malapposition during provisional treatment of bifurcational lesions. © 2016 Wiley Periodicals, Inc.
Mapping of circuit variables into two‐port network variables in basic amplifier structures: identifying new topologies
Authors: Elwakil A. S. , Maundy B. , Murtada M. A. 
Published: June 2013

ABSTRACTIn this paper, we report on a unique observation which enables the unification of the analysis for different amplifier structures. In particular, we report that the change from one type of amplifier to the other can be understood via a mapping of source‐load circuit variables (Vs, Rs, Ii, Io, IL, Vo) into two‐port network variables (V1, V2, I1, I2). As such, unified expressions for (Av,Zi,Ai,Zo) are derived. Further, a Matlab code is written to search for all valid mappings out of 38 different possibilities. Copyright © 2013 John Wiley & Sons, Ltd.
The influence of watershed run‐off on the hydrology, forest floor litter and soil carbon of headwater wetlands
Authors: Barksdale W. Flynt , Anderson Christopher J. , Kalin Latif 
Published: June 2013

ABSTRACTThe effects of land use and land cover (LULC) on aquatic systems have been extensively studied however less research has focused on headwater wetlands. This study was conducted to evaluate the effects of watershed land conversion and associated run‐off on the hydrology and carbon cycling of headwater wetlands in coastal Alabama, USA. A total of 15 headwater wetlands were selected to reflect a range of surrounding LULC across coastal Alabama. Land use and soil data were utilized to estimate watershed run‐off curve numbers (CN) that were used with precipitation data to calculate surface run‐off (Q). Within each wetland, water level recorders were installed to monitor ground water levels for 1 year and data were used to generate hydrological metrics related to stage and flashiness. Data varied among sites, but wetlands with higher watershed CN tended to have a greater tendency for water level measurements to exceed the normal fluctuation range (outliers). Carbon dynamics associated with leaf litter and soil storage were also measured during this time period. Leaf litter traps were installed to determine litter fall carbon input (CLF). Bimonthly monitoring of forest floor carbon (CFF) was conducted to evaluate its relationship to watershed run‐off. Soil carbon content was quantified in each wetland by collecting 40‐cm cores analysed at 10 cm sections. Watershed run‐off characteristics (CN and Q) were significantly related to mean CFF and CFF : CLF (CFF adjusted for the amount of CLF) suggesting that hydrologic export and possibly decomposition increased with run‐off. Surface soil (0–10 cm) carbon content was related to median groundwater level; however, no relationship was detected between soil carbon and CN or Q. Copyright © 2013 John Wiley & Sons, Ltd.
Morphological responses and sediment processes following a typhoon‐induced dam failure, Dahan River, Taiwan
Authors: Tullos Desiree , Wang Hsiao‐Wen 
Published: June 2013

ABSTRACTThe rates and styles of channel adjustments following an abrupt and voluminous sediment pulse are investigated in the context of site and valley characteristics and time‐varying sediment transport regimes. Approximately 10.5 x 106 m3 of stored gravel and sand was exposed when Barlin Dam failed during Typhoon WeiPa in 2007. The dam was located on the Dahan River, Taiwan, a system characterized by steep river gradients, typhoon‐ and monsoon‐driven hydrology, high, episodic sediment supply, and highly variable hydraulic conditions. Topography, bulk sediment samples, aerial photos, and simulated hydraulic conditions are analyzed to investigate temporal and spatial patterns in morphology and likely sediment transport regimes. Results document the rapid response of the reservoir and downstream channel, which occurred primarily through incision and adjustment of channel gradient. Hydraulic simulations illustrate how the dominant sediment transport regime likely varies between study periods with sediment yield and caliber and with the frequency and duration of high flows. Collectively, results indicate that information on variability in sediment transport regime, valley configuration, and distance from the dam is needed to explain the rate and pattern of morphological changes across study periods. Copyright © 2013 John Wiley & Sons, Ltd.
Novel DICER1 mutation as cause of multinodular goiter in children
Authors: Darrat Ilaaf , Bedoyan Jirair K. , Chen Ming , Schuette Jane L. , Lesperance Marci M. 
Published: June 2013

BackgroundThe aim of this report was to present a rare case of an adolescent with multinodular goiter (MNG) found to have a DICER1 mutation.Methods and ResultsThe methodology includes a presentation and discussion of a chart review including endocrine hormone tests, thyroid ultrasound, and genetic testing for DICER1. A 12‐year‐old girl presented with a diffusely enlarged thyroid gland. Family history revealed an older sister with a history of bilateral ovarian Sertoli‐Leydig cell tumors and MNG. Thyroid function tests were normal. Serial thyroid ultrasounds showed enlarging multiple bilateral nodules. Fine‐needle aspiration suggested MNG. Genetic testing revealed a novel heterozygous premature termination mutation (c.1525C>T p.R509X) in the DICER1 gene.ConclusionsThyroid nodules are rare in children but carry a higher risk for malignancy. It is essential to inquire about family history and refer for genetic evaluation with a family history of MNG. In patients with DICER1 mutations, tumor surveillance is critical due to the increased risk of multiple tumors, including ovarian tumors and pleuropulmonary blastoma. © 2013 Wiley Periodicals, Inc. Head Neck 35: E369–E371, 2013
Lack of association between high serum thyroid‐stimulating hormone level and risk of papillary thyroid microcarcinomas
Authors: Sohn Seo Young , Kim Hye Jeong , Jang Hye Won , Kim Sun Wook , Chung Jae Hoon 
Published: June 2013

BackgroundHigh serum thyroid‐stimulating hormone (TSH) is associated with thyroid carcinoma in patients with thyroid nodules. However, previous studies suggests that TSH is not involved in the pathogenesis of small thyroid carcinomas. We performed this study to evaluate serum TSH as a malignancy predictor in the assessment of small thyroid nodules.MethodsWe retrospectively analyzed 3791 patients who underwent thyroidectomy. We classified all patients into 3 to 5 groups by serum TSH or nodule size and analyzed the association of serum TSH and risk of papillary thyroid carcinoma (PTC).ResultsThe frequency of PTC increased as serum TSH increased. Serum TSH and older age were associated with the risk of PTC in multivariate analysis (p < .0001). In subgroup analysis, the risk of PTC increased as serum TSH increased with thyroid nodules > 1 cm (p < .05).ConclusionsSerum TSH may not be useful for clinical risk assessment of small thyroid nodules. © 2013 Wiley Periodicals, Inc. Head Neck 36: 43–46, 2014
Functional hemitongue reconstruction using innervated supraclavicular fasciocutaneous island flaps with the cervical plexus and reinnervated supraclavicular fasciocutaneous island flaps with neurorrhaphy of the cervical plexus and lingual nerve
Authors: Chen Wei‐liang , Zhang Da‐ming , Yang Zhao‐hui , Wang You‐yuan , Fan Song 
Published: June 2013

BackgroundThe purpose of this study was to evaluate tongue function in patients with tongue cancer after reconstruction with innervated supraclavicular fasciocutaneous island flaps (iSFIFs) with the cervical plexus (iSFIFs‐SPN) or reinnervated SFIFs with neurorrhaphy of the cervical plexus and lingual nerve (rSFIFs‐SPN‐LN).MethodsForty‐two tongue defects were reconstructed using iSFIFs‐SPN and rSFIFs‐SPN‐LN. Two‐point discrimination tests revealed a significant difference on the dorsal and ventral hemitongue reconstructed using rSFIFs‐SPN‐LN from control values.ResultsNo statistical difference in swallowing, speech, or esthetic outcome was found in the iSFIFs‐SPN or the rSFIFs‐SPN‐LN. A significant difference was noted in the dorsal aspect and ventral surface of hemitongues reconstructed with rSFIFs‐SPN‐LN from control values and between 6 and 12 months.ConclusionSensation after hemitongue reconstruction with the iSFIF‐SPN and the neurorrhaphy of the cervical plexus nerve was sutured to the lingual nerve, sensation after hemitongue reconstruction with the rSFIF‐SPN‐LN approached normal 6 to12 months postoperatively. © 2013 Wiley Periodicals, Inc. Head Neck 36: 66–70, 2014
Sentinel node biopsy as an alternative to elective neck dissection for staging of early oral carcinoma
Authors: Samant Sandeep 
Published: June 2013

BackgroundWe report the outcome of sentinel node biopsy (SNB) for staging the neck in a consecutive cohort of 34 patients with T1/2 clinically N0 oral carcinoma.MethodsSNB was performed along with resection of primary tumor. Neck dissection was reserved for failure of SNB or pathologically positive sentinel nodes (pN+).ResultsSentinel node identification was successful in 32 of 34 patients (94%); 2 patients with unsuccessful SNB underwent immediate neck dissection. Seven patients (21%) were pN+, 6 by SNB and 1 by elective neck dissection (END). Among 29 patients who were pN0 on SNB, nodal recurrence developed in 2 patients; both were surgically salvaged. Local failure developed in 1 patient. Two‐year overall and disease‐free survival was 87% and 80%, respectively.ConclusionSuccessful eradication of lymphatic metastasis noted in this study suggests that SNB may be a safe alternative to END for neck staging in patients with early oral carcinoma. © 2013 Wiley Periodicals, Inc. Head Neck 36: 241–246, 2014
Transoral laser microsurgery for oral squamous cell carcinoma: Oncologic outcomes and prognostic factors
Authors: Sinha Parul , Hackman Trevor , Nussenbaum Brian , Wu Ningying , Lewis James S. , Haughey Bruce H. 
Published: June 2013

BackgroundModest survival rates are published for treatment of oral squamous cell carcinoma (OSCC) using conventional approaches. Few cohort studies are available for transoral resection of OSCC.MethodsAnalysis for recurrence, survival, and prognosis of patients with OSCC treated with transoral laser microsurgery (TLM) ± neck dissection was obtained from a prospective database.ResultsNinety‐five patients (71 patients had stages T1–T2 and 24 had stages T3–T4 disease) with minimum follow‐up of 24 months met criteria and demonstrated negative margins in 95%. Five‐year local control (LC) and disease‐specific survival (DSS) were 78% and 76%, respectively. Surgical salvage achieved an absolute final locoregional control of 92%. Immune compromise and final margins were prognostic for LC, whereas T classification, N classification, TNM stage, comorbidity, and perineural invasion were also significant for DSS.ConclusionWe document a large series of patients with OSCC treated with TLM, incorporating T1 to T4 primaries. A significant proportion of stage III/IV cases demonstrates feasibility of TLM in higher stages, with final margin positivity of 5%, LC greater than 90%, and comparable survival outcomes. © 2013 Wiley Periodicals, Inc. Head Neck 36: 340–351, 2014
Super‐radical surgery for anaplastic thyroid carcinoma: A large cohort study using the anaplastic thyroid carcinoma research consortium of Japan database
Authors: Sugitani Iwao , Hasegawa Yasuhisa , Sugasawa Masashi , Tori Masayuki , Higashiyama Takuya , Miyazaki Masakazu , Hosoi Hiroshi , Orita Yorihisa , Kitano Hiroya 
Published: June 2013

BackgroundThe consequences of super‐radical resection in patients with anaplastic thyroid carcinoma (ATC) have not been fully investigated.MethodsThis retrospective study used the multicenter ATC Research Consortium of Japan database. Among 233 stage IVB patients, 23 underwent super‐radical resection (group S). Outcomes for group S were compared to those for patients with restricted curative surgery (group R; n = 49), palliative surgery (group P; n = 72) or no surgery (group N; n = 80).ResultsOne‐year cause‐specific survival rate for group S was 33%. It was identical to group R (p = .94) and significantly better than groups N and P (p = .0065). Permanent tracheostomy was significantly more frequent in group S than in other groups, but only 5 patients died directly from local disease.ConclusionsRadical resection offers significantly better outcomes than limited surgery. Super‐radical procedures may be indicated in select patients to avoid mortality due to locally uncontrolled disease at the expense of tracheostomy. © 2013 Wiley Periodicals, Inc. Head Neck 36: 328–333, 2014
Preoperative 18F‐FDG PET/CT and high‐risk HPV in patients with oropharyngeal squamous cell carcinoma
Authors: Joo Young‐Hoon , Yoo Ie‐Ryung , Cho Kwang‐Jae , Park Jun‐Ook , Nam In‐Chul , Kim Min‐Sik 
Published: June 2013

BackgroundTo evaluate the association of 18F‐fluorodeoxyglucose‐positron emission tomography (18F‐FDG PET/CT) and high‐risk human papillomavirus (HPV) status and to establish the histologic correlates in oropharyngeal cancer (OPSCC).MethodThe medical records of 78 patients who underwent 18F‐FDG PET/CT for OPSCC before surgery were reviewed.ResultsThe positive rate of high‐risk HPV in situ hybridization was 36% (28 of 78). The maximum standardized uptake values (SUVmax) of negativity for the high‐risk HPV subtypes (10.29 ± 4.30) and positivity (6.69 ± 4.17) were found to be significantly different (p = .001). The SUVmax cutoff value for differentiating negativity for the high‐risk HPV subtypes from positivity was 7.10, with the sensitivity of 78% and the specificity of 68%. A median SUVmax (using 7.10 as a cutoff) (p = .041) and high‐risk HPV status (p = .040) were found to be associated with 5‐year disease‐specific survival (DSS).ConclusionsMedian 18F‐FDG PET/CT SUVmax cutoff values 7.10 or greater are associated with a high‐risk HPV negativity in OPSCC patients. © 2013 Wiley Periodicals, Inc. Head Neck 36: 323–327, 2014
Cross‐facial nerve graft and masseteric nerve cooptation for one‐stage facial reanimation: Principles, indications, and surgical procedure
Authors: Bianchi Bernardo , Ferri Andrea , Ferrari Silvano , Copelli Chiara , Magri Alice , Ferri Teore , Sesenna Enrico 
Published: June 2013

BackgroundThe use of facial cross‐grafting in acquired recent unilateral facial palsy provides spontaneity and emotional activation. Masseteric nerve for facial animation has mainly been described for reinnervation of neuromuscular transplants, babysitter procedures, or direct facial nerve cooptation. The simultaneous use in a single procedure of cross‐facial nerve grafting and masseteric cooptation has not been described.MethodsEight patients underwent facial animation using single stage cross‐facial nerve grafting and masseteric nerve cooptation. The mean duration of facial palsy was 10.2 months (range, 1–23 months).ResultsVoluntary contraction in response to masseteric nerve activation was observed after 2 to 4 months. All patients underwent postoperative rehabilitation and spontaneous contraction was achieved in 7 to 13 months postoperatively. Cosmetic outcomes were evaluated as moderate in 1 patient, good in 5 patients, and excellent in the remaining 2 patients.ConclusionThis new technique could provide good results with fast, reliable, and powerful reinnervation, spontaneity, and low morbidity. © 2013 Wiley Periodicals, Inc. Head Neck 36: 235–240, 2014
Endoscopic supraomohyoid neck dissection via a retroauricular or modified facelift approach: Preliminary results
Authors: Byeon Hyung Kwon , Holsinger F. Christopher , Koh Yoon Woo , Ban Myung Jin , Ha Jong Gyun , Park Jeong Jin , Kim Dahee , Choi Eun Chang 
Published: June 2013

BackgroundBased on our previous experiences with endoscopic or robotic neck surgery utilizing the retroauricular (RA) or modified facelift (MFL) approach, we realized the value of verifying the feasibility of endoscopic supraomohyoid neck dissection (SOND). Therefore, the purpose of this study was to evaluate the potential role of endoscopic SOND.MethodsSix patients who underwent elective endoscopic SOND of the ipsilateral neck for biopsy proven head and neck cancer from January 2011 to February 2012 were analyzed.ResultsAll endoscopic operations via RA or MFL were successfully performed without any significant intraoperative complications or conversion to open surgery. Based on patient‐reported outcome questionnaires, all patients were satisfied with the cosmetic surgical outcomes.ConclusionEndoscopic selective neck dissection via an RA or an MFL approach is technically feasible and safe with satisfactory cosmetic results for patients with clinically node‐negative early‐stage head and neck cancer. © 2013 Wiley Periodicals, Inc. Head Neck 36: 425–430, 2014
Liposarcoma of the head and neck: Analysis of 318 cases with comparison to non–head and neck sites
Authors: Gerry Daniel , Fox Nyssa F. , Spruill Laura S. , Lentsch Eric J. 
Published: June 2013

BackgroundLiposarcomas are rare in the head and neck. We analyzed a large series of head and neck liposarcomas to determine features unique to the head and neck.MethodsThree hundred eighteen liposarcomas of the head and neck were contrasted with 9485 liposarcomas of other regions using the Surveillance, Epidemiology, and End Results (SEER) database.ResultsHead and neck liposarcomas were most commonly subcutaneous (81.%), low grade (70.1%; p < .001), and early stage (p < .001). They were more likely to be treated with surgery alone, whereas conventional liposarcomas were more likely to receive adjuvant radiation (p < .001). Treatment that included surgery had better survival than radiation therapy alone (p = .008). Overall, liposarcomas of the head and neck had significantly higher disease‐specific survival (DSS) and overall survival (OS) than conventional liposarcomas (p < .001).ConclusionLiposarcomas of the head and neck are usually early stage, low grade, and with fewer nodal metastases than conventional liposarcomas. DSS and OS were significantly greater for liposarcomas of the head and neck. © 2013 Wiley Periodicals, Inc. Head Neck 36: 393–400, 2014
Enhancement of head and neck squamous cell carcinoma proliferation, invasion, and metastasis by tumor‐associated fibroblasts in preclinical models
Authors: Wheeler Sarah Elizabeth , Shi Huifang , Lin Fangchen , Dasari Sumana , Bednash Joseph , Thorne Stephen , Watkins Simon , Joshi Radhika , Thomas Sufi Mary 
Published: June 2013

BackgroundHead and neck squamous cell carcinoma (HNSCC) has had little improvement in mortality rates in decades. A clearer understanding of the HNSCC tumor microenvironment will aid in finding more effective targeted therapies for this disease. Tumor‐associated fibroblasts (TAFs) are the largest stromal cellular components of the tumor microenvironment in HNSCC.MethodsWe isolated TAFs from clinical HNSCC cases and propagated in vitro. The effects of TAF‐secreted paracrine factors on in vitro HNSCC migration, invasion, and proliferation was assessed. The effect of TAFs on HNSCC growth and metastases was determined in an orthotopic floor‐of‐the‐mouth tumor model.ResultsTAF‐conditioned media increased HNSCC cell migration, invasion, and proliferation. TAFs increased HNSCC tumor growth and metastases in vivo.ConclusionTAFs play a major role in increasing tumor growth and metastasis in HNSCC. Targeting the tumor stroma may be important to reduce the rate of HNSCC metastasis. © 2013 Wiley Periodicals, Inc. Head Neck 36: 385–392, 2014