bluuebunny/crossref_metadata_2025_split huggingface dataset:
Aqueous Acidic Pectin‐Based Solution as Electrolyte and Pretreatment Solution for Zinc Ion Battery Anodes
Authors: Jang Jooyoung , Lim Won‐Gwang , Jo Changshin 
Published: July 2024

AbstractWhile considerable progress has been achieved in aqueous mildly acidic Zn‐ion batteries (AZIBs), the development of metallic Zn anodes remains challenging due to dendritic growth and side reactions on the Zn surface in mildly acidic aqueous environments. Herein, we utilize pectin in two ways: firstly, as an additive for the acidic ZnSO4 electrolyte with pectin (referred to as ZSP); and secondly, as a component in the pretreatment solution for Zn electrode. The ZSP electrolyte can prevent the formation of inactive Zn4(OH)6(SO4) ⋅ 5H2O byproduct on Zn electrode and enable stable cycling under challenging conditions at 10 mA h cm−2. Interestingly, the immersion of the Zn foil in the acidic pectin solution resulted in the uniform removal of the bumpy oxides/carbonates layer on the Zn metal surface. The cells with treated Zn electrode in pectin solution exhibited lower overpotentials and effectively inhibited cell failure. Our findings indicate that utilizing an organic‐based acidic ZnSO4 electrolyte shows promise as both an effective electrolyte and a pretreatment solution for the development of stable and cheap aqueous AZIB electrolytes.
Characterization of cellulose nanocrystals from Zhombwe (Neorautanenia brachypus (harms) CA Sm.) bagasse
Authors: Makanda Rumbidzai A. , Chikwambi Zedias , Murungweni Chrispen , Kakwere Hamilton , Mashingaidze Arnold B. 
Published: July 2024

AbstractIncreased awareness of environmental pollution has changed focus to the use of biodegradable materials because they lack persistence in the environment. This article focused on the production of cellulose nanocrystals from Zhombwe, Neorautanenia brachypus (Harms) CA Sm. bagasse using steam explosion, alkaline treatment, bleaching, purification, and acid hydrolysis. The chemical composition after the treatments was determined using TAPPI standards. Further characterization was done using x‐ray Diffraction (XRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). The nanoscale dimensions and morphology of the extracted nanocrystals was determined through field emission scanning electron microscopy (FE‐SEM). FTIR spectroscopy and DSC confirmed the removal of noncellulosic compounds. XRD revealed that N. brachypus bagasse contained cellulose type I, which partly endured morphological change to polymorph II after purification and hydrolysis. FE‐SEM revealed elliptical to rod‐shaped structures after acid hydrolysis, which had a mean length and width of 1103 nm and 597 nm respectively. TAPPI tests revealed that successive chemical treatments increased crystallinity by 29.7%, enriched cellulose content by 74.2%, reduced lignin content by 21.7%, and reduced hemicellulose to less than 1%. The semicrystalline nature of the material produced in our work is a promising candidate for swelling hydrogel applications in areas such as wound dressing, heavy metal removal, controlled drug delivery, agriculture, and sanitary products. Future studies may focus on surface modification of nanocrystals to improve their thermal stability and therefore expand their range for potential industrial applications.
Integrating metabolomics and bioinformatics to reveal the mechanism of Epimedium‐induced liver injury
Authors: Wang Jiaqi , Cao Yijia , Sun Mo , Zhang Tonghua , Yu Gengyuan , Xu Haoran , Li Tianyi , Zhang Chenning , Sun Yikun 
Published: July 2024

AbstractEpimedium is a traditional Chinese medicine with a wide range of clinical applications; however, there have been numerous reports of adverse reactions in recent years. The most common side effect of Epimedium is liver injury. In this study, the liquid chromatography–mass spectrometry (LC–MS) method has been established to study the components of Epimedium and to identify the components absorbed into the blood of rats. Bioinformatics was used to screen out potential toxic components, and the integrating metabolomics method was used to explore the molecular mechanism of Epimedium‐induced liver injury. The chemical constituents of Epimedium were identified by LC–MS, and 62 compounds were obtained, including 57 flavonoids, four organic acids and one alkaloid. The toxicity network of “Epimedium–component–target–liver injury” was constructed using bioinformatics research methods, and then the key hepatotoxic component icaritin was identified. Integrating metabolomics was used to investigate the changes in the metabolic profile of L‐02 cells with different durations of icaritin administration compared with the control group, and 106 different metabolites were obtained. A total of 14 potential biomarkers significantly associated with cell survival were screened by Pearson correlation analysis combined with the L‐02 cell survival rate. Our study preliminarily revealed the mechanism of hepatotoxicity induced by Epimedium.
Iron‐Sulfur Peptides Mimicking Ferredoxin for an Efficient Electron Transfer to Hydrogenase
Authors: Terranova Umberto 
Published: July 2024

AbstractIn the green alga Chlamydomonas reinhardtii, hydrogenase HydA1 converts protons and electrons to H2 at the H‐cluster, which includes a [4Fe−4S] cluster linked to a [2Fe] cluster. The yield of H2 is limited by the electron transfer to HydA1, mediated by the iron‐sulfur unit of a photosynthetic electron transfer ferredoxin (PetF). In this study, I have investigated by molecular dynamics and the hybrid quantum mechanics/molecular mechanics method two canonical iron‐sulfur peptides (PM1 and FBM) that hold potential as PetF replacements. Using a docking approach, I predict that the distance between the two iron‐sulfur clusters in FBM/HydA1 is shorter than in PM1/HydA1, ensuring a greater electron transfer rate. This finding is in line with the reported higher H2 production rates for FBM/HydA1. I also show that the redox potential of these peptides, and therefore their electron transfer properties, can be changed by single‐residue mutations in the secondary coordination sphere of their cluster. In particular, I have designed a PM1 variant that disrupts the hydrogen‐bonding network between water and the cluster, shifting the redox potential negatively compared to PM1. These results will guide experiments aimed at replacing PetF with peptides that can unlock the biotechnological potential of the alga.
Mono‐ADP‐Ribosylation of Peptides: An Overview of Synthetic and Chemoenzymatic Methodologies
Authors: Minnee Hugo , Codée Jeroen D. C. , Filippov Dmitri V. 
Published: July 2024

AbstractAdenosine diphosphate (ADP)‐ribosylation is a ubiquitous post‐translational modification that regulates vital biological processes like histone reorganization and DNA‐damage repair through the modification of various amino acid residues. Due to advances in mass‐spectrometry, the collection of long‐known ADP‐ribose (ADPr) acceptor sites, e. g. arginine, cysteine and glutamic acid, has been expanded with serine, tyrosine and histidine, among others. Well‐defined ADPr‐peptides are valuable tools for investigating the exact structures, mechanisms of action and interaction partners of the different flavors of this modification. This review provides a comprehensive overview of synthetic and chemoenzymatic methodologies that enabled the construction of peptides mono‐ADP‐ribosylated on various amino acids, and close mimetics thereof.
Paravalvular leak closure after TAVI with plugs: A literature review with a specific focus on arterio‐arterial loop
Authors: Flores‐Umanzor Eduardo , Cepas‐Guillén Pedro , Ruberti Andrea , Regueiro Ander , Sanchis Laura , Gabani Rami , Rodés‐Cabau Josep , Vidal Barbara , Freixa Xavier 
Published: July 2024

AbstractMore than mild paravalvular leak (PVL) following transcatheter aortic valve implantation (TAVI) is associated with a twofold increase in all‐cause mortality, heart failure hospitalizations, and the need for reintervention. Successfully addressing PVL in TAVIs is more challenging than in surgical valves. The arterial‐arterial (A‐A) rail technique emerges as a valuable strategy for post‐TAVI PVL closure, enhancing success rates by enabling the effective use of lower‐profile vascular plug devices. When standard approach is ineffective, generating an A‐A loop for post‐TAVI PVL closure is probably the most recommended strategy to ensure procedural success.
The impact of novel scoring balloon and cutting balloon after orbital atherectomy on severely calcified coronary lesion as assessed by optical coherence tomography
Authors: Kachi Daigo , Lee Tetsumin , Terui Mao , Nagase Masashi , Misawa Toru , Miyazaki Ryoichi , Kaneko Masakazu , Nagata Yasutoshi , Nozato Toshihiro , Ashikaga Takashi 
Published: July 2024

AbstractBackgroundDebulking devices are often followed by a scoring or cutting balloon in percutaneous coronary intervention (PCI) for severely calcified lesions. However, there are limited data on balloon preparation after orbital atherectomy (OA) assessed using optical coherence tomography (OCT).AimWe aimed to compare the effects of a novel scoring and cutting balloon on calcified coronary lesions with OCT.MethodsWe retrospectively examined 38 patients (38 lesions) who underwent PCI with a scoring or a cutting balloon after OA. All patients underwent pre‐PCI, preballooning, postballooning, and post‐PCI OCT imaging. We divided the patients into novel scoring‐balloon (group A: n = 22) and cutting‐balloon (group B: n = 16) groups and compared the OCT findings, including minimum lumen area (MLA) and expansion ratio (MLA divided by mean reference lumen area).ResultsThe mean patient age was 76.1 ± 8.7 years; 71.5% were male. There were no significant differences in patient background between both groups. Regarding procedural characteristics, the maximum balloon pressure was significantly higher in group A (median 23 atm, interquartile range [IQR] 18–24 vs. 12 atm [IQR: 10–12], p < 0.01). Although a calcium score of 4 was more frequently observed in group A (86.4% vs. 62.5%, p = 0.12), post‐PCI MLA was comparable between both groups (3.95 mm2 [IQR: 3.27–4.41] vs. 3.43 mm2 [IQR: 2.90–4.82], p = 0.63). Furthermore, the expansion ratio was significantly greater in group A (0.83 ± 0.20 vs. 0.68 ± 0.14, p < 0.01).ConclusionDespite a higher calcium score, a larger expansion ratio was achieved in patients with a novel scoring balloon than in those with a cutting balloon after OA.
A rare association of the absence of left pulmonary artery with ventricular septal defect, pulmonary hypertension, and more interestingly, patent ductus arteriosus in an adult patient: Case report and literature review
Authors: Parsaee Mozhgan , Saedi Sedigheh , Behrooj Soudabeh , Emami Elaheh , Salehi Pegah , Mohammadzadeh Ali 
Published: July 2024

Key Clinical MessageIn this study, we introduced one of the rarest concomitants of the absence of left pulmonary artery (LPA), which was seen in our patient along with patent ductus arteriosus (PDA) and ventricular septal defect (VSD).AbstractUnilateral absence of pulmonary artery (UAPA) is a congenital heart disease in association with other abnormalities such as tetralogy of Fallot and septal defects or isolated in 30% of cases and occurs in the right lung in two thirds of cases. Our case is a 33‐year‐old man who was hospitalized with symptoms of cough, shortness of breath, and hemoptysis. The echocardiography revealed a large ventricular septal defect, absent left pulmonary artery, and severe pulmonary hypertension (PH) along with patent ductus arteriosus. These findings were confirmed by CT angiography. This association has rarely been found in past studies. Due to PH and pulmonary infection, the patient was treated with intravenous prostaglandin and antibiotics. However, in cases of timely diagnosis and treatment of UAPA, fatal complications such as pulmonary hypertension, morbidity, and mortality are reduced. This case emphasizes the importance of awareness of this abnormality and its associated anomalies to enable early diagnosis and treatment.
Modular Synthesis of High Performance Energetic Biocidal Bicyclic Compounds Derivated from Iodopyrazoles
Authors: Zhao Xinyuan , Zhang Xun , Liu Yan , Pang Siping , He Chunlin 
Published: July 2024

AbstractModular synthesis can combine different functional modules to flexibly regulate comprehensive properties and study the diversity of compounds. This study established a modular bicyclic synthesis strategy of combining polynitro energetic module with iodine‐containing biocidal module. Compounds 1–6 with high iodine content (48.72–69.56 %) and high thermal stability (Td: 172–304 °C) were synthesized and exhaustively identified. By modular synthesis, the detonation properties and gas‐production of 3–6 improved greatly expanding their biocidal efficacy and maintained the iodine atomic utilization of iodine‐containing module. Notably, 4,5‐diiodo‐3,4’,5’‐trinitro‐1,3’‐bipyrazole (5) and 3,5‐diiodo‐4,4’,5’‐trinitro‐1,3’‐bipyrazole (6) exhibit high detonation velocities (D: 5903 m s−1, 5769 m s−1, respectively) and highest gas production of 212.85 L mol−1 and 217.66 L mol−1 after decomposition. This study diversifies polyiodio‐nitro compounds, and also inspire the implementation of similar synthesis strategies to provide family‐level synthetic solutions to energetic biocidal materials.
Acid‐catalyzed Transformation of Nitrite to Nitric Oxide on Copper(II)−Cobalt(II) Centers in a Bimetallic Complex
Authors: Biswas Jyotiprokash , Kulbir fnm/> , Bhardwaj Prabhakar , Ghosh Somnath , Chandra Sahoo Subash , Apfel Ulf‐Peter , Kumar Pankaj 
Published: July 2024

AbstractNitrite (NO2−) serves as a pool of nitric oxide (NO) in biological systems under hypoxic conditions, and it is transformed to NO by nitrite reductase (NiR) enzyme in the presence of acid (H+ ions). However, NO synthases (NOSs) generate NO via L‐arginine oxidation in normoxic conditions. Previously, acid‐induced NO2− reduction chemistry was modeled on mono‐metallic 3d‐metals, generating metal‐nitrosyls or NO(g) with H2O or H2O2 products. Herein, to understand the relative potency of a bimetallic system, we report the acid‐induced reductive conversion of η2‐bound NO2− to NO on CuII−CoII centers of a hetero‐bimetallic CuII‐nitrito‐CoII complex, [(LN8H)CuII−NO2−−CoII]3+ (CuII−NO2−−CoII, 2) bearing an octadentate N8‐cryptand ligand (LN8H). The CuII−NO2−−CoII generates [CuII(LN8H)CoII]4+ (1) upon reaction with one equiv. acid (HClO4, H+ ions source) with NO(g) via a presumed transient nitrousacid (ONOH) intermediate species. Likewise, this NO2− reduction was found to form H2O, which is believed to be from the decomposition of H2O2, an intermediate species. In addition, complex 2, in the presence of more than one equiv. H+ ions also showed the formation of NO(g) with H2O. Mechanistic investigations, using 15N‐labeled‐15NO2−, 18O‐labeled‐18O14N16O− and 2H‐labeled‐DClO4 (D+ source), revealed that the N‐atom and O‐atom in the 14/15NO and 14N18O gases are derived from NO2− ligand and H‐atom in H2O derived from H+‐source, respectively.
A Well‐Defined Magnesium Complex of C706−
Authors: Lawrence Samuel R. , Demidov Nikita , André Ohlin C. , Cordes David B. , Slawin Alexandra M. Z. , Stasch Andreas 
Published: July 2024

AbstractControlling and understanding charge state and metal coordination in carbon nanomaterials is crucial to harnessing their unique properties. Here we describe the synthesis of the well‐defined fulleride complex [{(Mesnacnac)Mg}6C70], 2, (Mesnacnac)=HC(MeCNMes)2, Mes=2,4,6‐Me3C6H2, from the reaction of the β‐diketiminate magnesium(I) complex [{(Mesnacnac)Mg}2] with C70 in aromatic solvents. The molecular structure of complex 2 was determined, providing the first high‐quality structural study of a complex with the C706− ion. In combination with solution state NMR spectroscopic and DFT computational studies, the changes in geometry and charge distribution in the various atom and bond types of the fulleride unit were investigated. Additionally, the influence of the (Mesnacnac)Mg+ cations on the global and local fulleride coordination environment was examined.
Applicability of a Spinning Disk Apparatus for the Investigation of Particulate Fouling
Authors: Klinkert Annika , Deponte Hannes , Gottschalk Nathalie , Augustin Wolfgang , Scholl Stephan 
Published: July 2024

AbstractThe applicability of a fluidically heated spinning disk apparatus (SDA) was tested for investigating the influence of the tangential velocity on the deposition of particulate material systems, in particular on latex particles. First, the SDA was characterized for particle fouling investigations with micro glass beads as a model system, then, a first series of tests was carried out with a real material system, a vinyl acetate/Versa 10 copolymer. Experiments were performed for a duration of 1 h and a tangential velocity up to 0.3 m s−1. The fouling process was characterized by the local fouling layer thickness and the calculated local mass‐based fouling resistance. A decrease in fouling resistance along the radius of the rotating disk as a function of the tangential velocity was observed.
Current patterns of care and outcomes for dermatofibrosarcoma protuberans: An international multi‐institutional collaborative
Authors: Winer Leah K. , Akumuo Rita , Fredette Jordan D. , Deng Mengying , Hasler Jill S. , Greco Stephanie H. , von Mehren Margaret , Bartholomew Alex J. , Blazer Dan G. , Gabrielova Lucie , Adamkova Dagmar , Bernard‐Bedard Ericka , Nessim Carolyn , Kollár Attila , Olariu Radu , Cencelj‐Arnez Romi , Hompes Daphne , Ford Samuel J. , Cardona Kenneth , Sato Kenji , Iwata Shintaro , Farma Jeffrey M. , Villano Anthony M. 
Published: July 2024

AbstractBackgroundDermatofibrosarcoma protuberans (DFSP) is a cutaneous sarcoma with an infiltrative growth pattern that makes it challenging to clear margins. High quality data regarding DFSP natural history, management, and outcomes are limited.MethodsData were retrospectively collected for adult DFSP patients who underwent resection at 10 institutions in eight countries. Demographics, tumor characteristics, treatment strategies, and outcomes were analyzed.ResultsAnalysis included 347 patients consisting of young (median, 42 years), White (76.2%), males (54.2%) with truncal lesions (57.3%). The majority (76.8%) were symptomatic at presentation. Preoperative imaging was used in 55.9% of cases. Diagnosis was established with excisional biopsy in 50.9% versus incisional biopsy in 25.0% of cases. Despite planned margins of >1.0 cm in 67.4% of cases, only 69.0% of patients achieved R0 resection. Twenty‐two percent of patients underwent at least one re‐excision. R0 resection was achieved at a second procedure in 80.2% and a third procedure in 86.2%. Ultimately, R0 resection was feasible in 89.5% of all patients. Fibrosarcomatous transformation (FST) was observed in 12.6%. In total, 6.6% (N = 23) recurred (17 local, six distant). Of the six distant recurrences, 50.0% had FST. With a median follow‐up of 47.0 months, disease‐specific survival rate was 98.8%. In multivariable analysis, R0 margins at index resection were associated with wider circumferential margins and non‐FST histology.ConclusionsIn this international, multicenter collaborative, DFSP practice patterns were heterogeneous but achieved favorable recurrence rates and survival. Multiple excisions to clear margins remain commonplace and can inform future efforts to optimize margin selection.
Clinical outcomes of liposomal irinotecan in patients with advanced pancreatic cancer previously treated with conventional irinotecan: A meta‐analysis of real‐world evidence
Authors: Gupta Amol , De Jesus‐Acosta Ana , Le Dung , Pishvaian Michael , Zaidi Neeha , Zheng Lei , Laheru Daniel 
Published: July 2024

AbstractBackgroundPivotal clinical trials supported survival benefits of liposomal irinotecan (nal‐IRI) plus fluorouracil/leucovorin in patients with pancreatic ductal adenocarcinoma (PDAC) who previously received gemcitabine‐based therapy. There are concerns about the benefits of nal‐IRI in patients who received FOLFIRINOX (combined fluorouracil, leucovorin, IRI, and oxaliplatin) because of potential cross‐resistance to IRI. The objective of this meta‐analysis was to characterize the impact of the previous receipt of IRI on the outcomes of nal‐IRI regimens in patients with advanced PDAC.MethodsReal‐world studies evaluating the outcomes of nal‐IRI in patients who had prior IRI exposure published up to April 2023 were searched using electronic databases. The meta‐analysis was conducted using a random effects model to estimate pooled hazard ratios (HRs) and 95% confidence intervals (CIs).ResultsEight studies (n = 1368 patients) were included. The pooled median progression‐free survival (PFS) was 2.02 months (95% CI, 1.43–2.57 months), and the median overall survival (OS) was 4.26 months (95% CI, 3.03–5.39 months). Patients with prior IRI exposure had PFS (HR, 1.17; 95% CI, 0.94–1.47; p = .17) and OS (HR, 1.16; 95% CI, 0.95–1.42; p = .16) comparable to patients without prior IRI exposure. Likewise, patients who had progressive disease on conventional IRI had PFS (HR, 1.50; 95% CI, 0.73–3.08; p = .24) and OS (HR, 1.70; 95% CI, 0.68–4.27; p = .26) with nal‐IRI comparable to patients who had no progressive disease.ConclusionsPrior IRI exposure does not affect the survival outcomes of nal‐IRI regimens in patients who have advanced PDAC. The selection of later lines of chemotherapy regimens should be based on the differential safety profile, patient status, the cost of treatment, and health‐related quality of life.
Effect of dispersive electrode position (anterior vs. posterior) in epicardial radiofrequency ablation of ventricular wall: A computer simulation study
Authors: Irastorza Ramiro M. , Hadid Claudio , Berjano Enrique 
Published: July 2024

AbstractAn epicardial approach is often used in radiofrequency (RF) catheter ablation to ablate ventricular tachycardia when an endocardial approach fails. Our objective was to analyze the effect of the position of the dispersive patch (DP) on lesion size using computer modeling during epicardial approach. We compared the posterior position (patient's back), commonly used in clinical practice, to the anterior position (patient's chest). The model considered ventricular wall thicknesses between 4 and 8 mm, and electrode insertion depths between .3 and .7 mm. RF pulses were simulated with 20 W of power for 30 s duration. Statistically significant differences (P < .001) were found between both DP positions in terms of baseline impedance, RF current (at 15 s) and thermal lesion size. The anterior position involved lower impedance (130.8 ± 4.7 vs. 146.2 ± 4.9 Ω) and a higher current (401.5 ± 5.6 vs. 377.5 ± 5.1 mA). The anterior position created lesion sizes larger than the posterior position: 8.9 ± 0.4 vs. 8.4 ± 0.4 mm in maximum width, 8.6 ± 0.4 vs. 8.1 ± 0.4 mm in surface width, and 4.5 ± 0.4 vs. 4.3 ± 0.4 mm in depth. Our results suggest that: (1) the redirection of the RF currents due to repositioning the PD has little impact on lesion size and only affects baseline impedance, and (2) the differences in lesion size are only 0.5 mm wider and 0.2 mm deeper for the anterior position, which does not seem to have a clinical impact in the context of VT ablation.