bluuebunny/crossref_metadata_2025_split huggingface dataset:
Observations of professional–patient relationships: A mixed-methods study exploring whether familiarity is a condition for nurses’ provision of psychosocial support
Authors: Hill Hazel C , Paley John , Forbat Liz 
Published: August 2013

Background: There is a popular belief that the professional–patient relationship is a prerequisite in the provision of psychosocial support. Studies suggest that professionals must know, or be familiar with, a patient in order to effectively provide psychosocial support. Aim: To examine the association between familiarity and the provision of psychosocial care by professionals. Design: A mixed-methods study involving participant observation, interviews and organisational and documentary analysis was conducted over 8 months in an inpatient hospice setting. Participants: In total, 38 nurses (registered and auxiliary) and 47 patients were included in a maximum variation sampling strategy. Data were analysed using both qualitative and quantitative techniques. Results: The data disconfirm the belief that familiarity is either a necessary or sufficient condition for the provision of psychosocial support. Nurses familiar with patients did not necessarily respond to patients’ psychosocial needs, and nurses with no prior contact with the patient immediately dealt with psychosocial needs. Conclusion: Psychosocial support can be provided on a patient’s first contact with a clinician and does not rely on building a professional–patient relationship. This suggests that high-quality psychosocial care can be provided in the short time frame available to palliative care clinicians.
Research on psychological and social factors in palliative care: An invited commentary
Authors: Rodin Gary 
Published: August 2013

Background: Psychosocial factors are a major determinant of well-being in patients with advanced disease. However, the development of valid and reliable measures of meaningful and relevant outcomes and randomized controlled trials to assess the impact of novel interventions are relatively recent accomplishments. Aim: To discuss significant developments in psychosocial research, including work of the author, in palliative populations and to identify areas where uncertainty and controversy persist. Design: The impact of systematic research on psychosocial factors in palliative care over the past four decades is discussed. Particular attention is paid to the development of relevant measures of psychological outcomes and to the results of pilot studies and randomized controlled trials of psychosocial interventions. Results: A variety of factors, including methodological limitations, protective attitudes of health-care providers, and the progressive deterioration of patients with terminal disease, have presented obstacles to psychosocial research in palliative care. The more recent development of valid and reliable measures of psychological distress and psychological well-being has significantly advanced research in the field. Pilot studies and randomized controlled trials of psychosocial interventions have yielded promising results, although the demonstrated impact on primary outcomes in these studies has typically been modest. Conclusion: Psychosocial research in palliative care has grown in rigor and volume over the past several decades, and a variety of novel interventions have been developed and evaluated. However, the findings from this research have only begun to have an impact on clinical practice in palliative care.
MRI findings before and after prolapse surgery
Authors: Alt Céline D , Brocker Kerstin A , Lenz Florian , Sohn Christof , Kauczor Hans-Ulrich , Hallscheidt Peter 
Published: August 2013

Background Therapeutical outcome after prolapse surgery is evaluated using a standardized grading system based on maximum prolapse extent, which might not provide the full picture of the patient’s subjective outcome. We therefore applied an evaluation method, which is detached from a grading system. Purpose To evaluate the impact of pelvic organ mobility in dynamic magnetic resonance imaging (MRI) before and after mesh-repair surgery in patients with symptomatic pelvic organ prolapse. Material and Methods To obtain measurements, we performed parasagittal T2-weighted turbo spin echo sequence at rest (TR, 3460 ms; TE, 85 ms; matrix, 512; slice thickness [ST], 5 mm), parasagittal T2-weighted true fast imaging with steady-state precession (TrueFISP) single-shot sequence during straining (TR, 397.4 ms; TE, 1.5 ms; matrix, 256; ST, 8 mm), and parasagittal T2-weighted TrueFISP sequence at maximum strain (TR, 4.3 ms; TE, 2.15 ms; matrix, 256; ST, 5 mm) at 1.5 T MRI. Pelvic organ prolapse (anatomical landmarks: bladder, cervix, pouch, rectum) was measured perpendicularly with reference to the pubococcygeal and the midpubic line. Pelvic organ mobility was defined as the difference between the measured distance at rest and at maximum strain for each anatomical landmark. All patients underwent mesh-repair procedure. Eighty patients could be included in this short-term follow-up study. Due to the physical diagnosis of pelvic organ prolapse, 51 underwent anterior mesh repair, 16 underwent posterior mesh repair, and 13 underwent total mesh repair. Surgery was performed by one surgeon, using mesh implants from several manufacturers. Results Median values of maximum organ prolapse for bladder, cervix, pouch, and rectum preoperatively were 2.54 cm, 0.33 cm, 2.47 cm, and 0.32 cm, respectively, and 12 weeks postoperatively 0.87 cm, −1.79 cm, 1.49 cm, and 0.49 cm, respectively. Highly significant improvement ( P < 0.001) of pelvic organ mobility was observed in the treated compartment at 4- and 12-week follow-up. Physical evaluation 12 weeks after mesh-repair showed an asymptomatic POP-Q stage I, if any. Conclusion Dynamic MRI is useful in visualizing the maximum extent of pelvic organ prolapse, as the evaluation of pelvic organ mobility documents the intraindividual therapeutic outcome detached from a grading system based on maximal prolapse values.
Ventricular dilatation in ex-prematures: only confined to the occipital region? MRI-based normative standards for 19-year-old ex-prematures without major handicaps
Authors: Aukland Stein M , Elgen Irene B , Odberg Morten D , Chong W Kling , Eide Geir E , Rosendahl Karen 
Published: August 2013

Background Premature birth may be associated with white matter injury later developing with widening of the ventricles. However, population-based data on normal ventricular size by age are sparse, making the evaluation of possible ventricular dilatation difficult. Purpose To present the linear measurements of the ventricular system, to compare these to subjectively assessed ventricular size, and to examine differences in ventricular size between ex-prematures and controls. Material and Methods Eligible survivors ( n = 113) from the initial birth cohort ( n = 217, born in 1986–1988, birth weight <2000g) underwent MRI during 2006–2007. One hundred and three were ex-premature and included in the study. The ventricular size was subjectively judged by a pediatric neuroradiologist, and scored as normal, mildly, moderately, or severely dilated. Objective measurements, including width and depth of the frontal and occipital horns, were performed in a blinded fashion, by a pediatric radiologist. Results The normative standards for different parts of the ventricular system in ex-premature young adults varied considerably. We found significant associations between the objective measurements and the subjectively classification of ventricular dilatation. Ex-prematures had smaller heads than those born term (control group). After adjustment for head circumference, there were no significant group differences regarding the frontal horns, but the occipital horns were proportionately wider among ex-prematures. Conclusion Young adults born prematurely, with a birth weight <2000 g, do not have larger lateral ventricles than healthy controls born term, even after correcting for a smaller head size. However, they do have larger occipital horns, confirming previous studies and strengthening our belief of a specific vulnerability of the occipital region.
Application of parecoxib in post-uvulopalatopharyngoplasty analgesia
Authors: Xie Guang-Lun , Chu Qin-Jun , Liu Chun-Lan 
Published: August 2013

Objective To investigate the postoperative analgesic effects of parecoxib for uvulopalatopharyngoplasty (UPPP). Methods Patients with obstructive sleep apnoea syndrome who underwent UPPP were randomly divided into two groups. In group A, the incision-local block was performed with 5 ml of 0.5% ropivacaine injected subcutaneously before the end of surgery, then 20 ml of physiological saline was injected intravenously every 12 h for 2 days. In group B, in addition to the incision-local block, 40 mg parecoxib was injected intravenously 30 min before the end of UPPP and 40 mg parecoxib was injected intravenously every 12 h for 2 days. Postoperative pain was measured using a visual analogue scale (VAS). Adverse reactions were recorded. Results A total of 40 patients were randomized ( n = 20 per group). Under resting conditions, the mean ± SD VAS pain scores were significantly higher in group A compared with group B at 24 h and 48 h after UPPP (24 h 4.0 ± 0.8 versus 2.6 ± 0.6; 48 h 3.8 ± 0.7 versus 2.4 ± 0.5; respectively). Under swallowing conditions, the mean ± SD VAS pain scores were significantly higher in group A compared with group B at 8 h, 24 h and 48 h after UPPP. Postoperative adverse reactions were similar in the two groups. Conclusion Intravenous parecoxib combined with incision-local ropivacaine provided effective postoperative analgesia for patients with obstructive sleep apnoea syndrome, undergoing UPPP.
Rocuronium reversed by sugammadex versus mivacurium during high-risk eye surgery: An institutional anaesthetic practice evaluation
Authors: Quillfeldt Susanne von , Föhre Bettina , Andrees Nicolai , Spies Claudia D , Galvagni Daniele , Joussen Antonia M , Wernecke Klaus D , Boemke Willehad 
Published: August 2013

Objective This institutional anaesthetic practice evaluation compared patient safety with respect to residual neuromuscular blockade (NMB) at the time of tracheal extubation in patients undergoing high-risk eye surgery. Methods Two muscle relaxation regimens were compared: rocuronium administered via intravenous (i.v.) bolus dosing combined with reversal through sugammadex at end of surgery (group R/S; 17 patients); mivacurium administered via continuous i.v. infusion without antagonization (group M; 22 patients). Train-of-four (TOF) monitoring determined the depth of NMB. Results The TOF ratio at the time of tracheal extubation was greater in group R/S (median 1.03) than in group M (median 0.62). Time from end of surgery to tracheal extubation was not significantly different. The surgeons were 100% satisfied with the working conditions provided under both relaxation regimens. Conclusions Residual postoperative curarization at the time of extubation was frequently observed in group M, whereas there was complete recovery in group R/S. Reversal of NMB by sugammadex provides an additional safety dimension to patient care and should thus be considered especially for those at risk of airway complications or aspiration, in addition to frail patients.
The effect of blood glucose regulation on the presence of opportunistic Demodex folliculorum mites in patients with type 2 diabetes mellitus
Authors: Gökçe Cumali , Aycan-Kaya Özlem , Yula Erkan , Üstün İhsan , Yengil Erhan , Sefil Fatih , Rizaoglu Hatice , Gultepe Bilge , Bayram Fahri 
Published: August 2013

Objectives To measure the rate of Demodex folliculorum mite infestation in patients with type 2 diabetes mellitus and to investigate if it was related to blood glucose control. Methods Patients with type 2 diabetes were classified according to their glycosylated haemoglobin (HbA1c) level into two groups: a well controlled blood glucose group (HbA1c ≤ 7%) and a poorly controlled blood glucose group (HbA1c > 7%). A standardized skin surface biopsy method was used to determine if the patients had D. folliculorum infestation (>5 mites/cm2 of skin). Results A total of 69 patients (38 female) were enrolled in the study. Seventeen (24.6%) patients had D. folliculorum infestation. There were no significant differences in age, sex or body mass index between patients with and without D. folliculorum infestations. A significantly higher proportion of patients with poor blood glucose control had D. folliculorum infestation compared with patients with well controlled blood glucose. Conclusions These current findings suggest that poor blood glucose regulation increases the susceptibility to D. folliculorum mite infestation in patients with type 2 diabetes.
The GraftLink Ulnar Collateral Ligament Reconstruction
Authors: Lynch Jamie L. , Pifer Matthew A. , Maerz Tristan , Kurdziel Michael D. , Davidson Abigail A. , Baker Kevin C. , Anderson Kyle 
Published: August 2013

Background: Ulnar collateral ligament (UCL) reconstruction aims to restore valgus stability, and numerous techniques have been described in the literature. Hypothesis/Purpose: To biomechanically compare the GraftLink (GL) technique with traditional bone tunnels used in the docking (DO) technique. It is hypothesized that the GL method will offer a stiffer, less lax construct compared with the DO. Study Design: Controlled laboratory study. Methods: Native and reconstructed states were tested in 7 matched pairs of cadaveric arms. To test kinematics, a 1.5-N·m valgus torque was applied and the resultant displacement at 15° to 90° of flexion was measured. Dissipated energy and the torque at the peak of the 10th cycle of preconditioning were analyzed during kinematic tests. Failure testing was performed by internal rotation of the humerus at 4.5 deg/s in 70° of flexion. Ulnotrochlear joint (UTJ) gapping was quantified during failure tests by use of video tracking. Results: Kinematics testing revealed no differences between the native state and the reconstructed state in either the DO or the GL group at any flexion angle. Stiffness was lower in the reconstructed specimens in both the DO (39.92 N·m/rad) and GL (50.74 N·m/rad) groups compared with their matched native states (DO Native, 71.41 N·m/rad, P = .005; GL Native, 86.36 N·m/rad, P = .002). There was no difference in stiffness between DO and GL. Reconstructed specimens in the GL group had lower torque at failure compared with native specimens (17.404 N·m vs 24.63 N·m, P = .038), but there was no difference in the DO group at failure. There was no difference in torque at failure between DO and GL. The DO exhibited higher angular displacement at failure compared with the native state (34.21° vs 21.79°, P = .010) and compared with the GL when normalized (1.58-fold vs 1.19-fold, P = .039). Compared with their native states, both DO and GL had significantly higher UTJ gapping at 3 N·m and at failure. The DO had significantly higher normalized UTJ gapping than the GL at 3 N·m ( P = .037 ) and at failure ( P = .043). Conclusion: The DO and GL both restored joint kinematics under low loading conditions. Although less stiff, the GL exhibited lower joint gapping and laxity than did the DO. Clinical Relevance: Understanding the biomechanics of UCL reconstruction has significant implications for postoperative management as it relates to early rehabilitation. Biomechanically inferior constructs could risk graft failure or early loosening during rehabilitation, and comparing the biomechanics of new techniques to established, widely used procedures such as the docking technique can provide important information about the immediate postoperative performance.
CT Density Analysis of the Medial Cuneiform
Authors: Panchbhavi Vinod K. , Boutris Nickolas , Patel Karan , Molina Domingo , Andersen Clark R. 
Published: August 2013

Background: A cannulated lag screw inserted through the medial cuneiform into the base of the second metatarsal is often utilized to reduce the diastasis and aid healing of Lisfranc injuries. Also procedures such as a midfoot or a Lapidus arthrodesis require adequate implant-bone purchase in the medial cuneiform. The medial cuneiform contains cancellous bone of varying density. Knowledge of density variation may be helpful for implant usage and manufacturing of area specific implants. Methods: In 60 randomly selected patients, mean computed tomography (CT) intensity in Hounsfield units was measured at 12 sampled locations within the medial cuneiform and served as a proxy for bone density. The patients’ age, gender, and race were recorded. An analysis of variance (ANOVA) assessed the effect of age, gender, race, and sample site on bone density. Statistical testing assumed 95% level of confidence. Results: ANOVA showed age, gender, and sample site had significant effects ( P < .001) on bone density, though race had no significant effect ( P = .28). The distal-dorsal-lateral (DDL) site was significantly denser than all other sites ( P < .001) except the middle-dorsal-lateral (MDL) ( P = .53). The proximal-plantar-lateral (PPL) site was significantly less dense than all other sites ( P < .001) except the middle-plantar-lateral/medial and the proximal-plantar-medial sites ( P < .14). A general trend of density increasing in the distal and dorsal directions was evident, and within the dorsal sites there was a trend of increasing density in the lateral direction. Conclusion: This is the first study to date to measure density of the medial cuneiform using living subjects. The sample size of 60 patients was also the largest of any study measuring density of this bone. We conclude that the densest area of the medial cuneiform is the most anterior, dorsal, and lateral portion. Clinical Relevance: The findings of this study may indicate the most optimal area for implant purchase in the medial cuneiform when reducing the diastasis between the base of the second metatarsal and medial cuneiform and for stabilization of the medial column.
Pain reports in children and adolescents with type 1 diabetes mellitus
Authors: Tran Susan T , Salamon Katherine S , Hainsworth Keri R , Kichler Jessica C , Davies W Hobart , Alemzadeh Ramin , Weisman Steven J 
Published: August 2013

The purpose of this study is to examine prevalence rates of pain reports in youth with type 1 diabetes mellitus (T1DM) and potential predictors of pain. Pain is a common and debilitating symptom of diabetic polyneuropathies. There is currently little research regarding pain in youth with T1DM. It was predicted that self-care and general health factors would predict pain as suggested by the general pain literature. Participants ( N = 269) ranged in age from 13 to 17 years; youth had a mean time since diagnosis of 5.8 years. Data collected included diabetes self-management variables, ratings of the patient’s current functioning and pain intensity (‘current’), and information collected about experiences that occurred in the time preceding each appointment (‘interim’). About half of the youth ( n = 121, 49.0%) reported any interim pain across both appointments. Female adolescents and those individuals who were physically active and/or utilized health-care system more acutely were more likely to report interim central nervous system pain. Improved diabetes self-management and increased level of physical activity may reduce experiences of pain and increase the quality of life of youth with T1DM. Regular monitoring of both current and interim pain experiences of youth with T1DM is recommended.
Comparison of utility scores from the Visual Analog Scale and Health Utilities Index 3 in children following pediatric intensive care unit admission
Authors: Ebrahim Shanil , Parshuram Christopher 
Published: August 2013

Indirect and direct health-related quality of life (HRQoL) measures are intended to assess the same underlying constructs. There is evidence that the two types of assessments can show important differences. We assessed the agreement between the utilities of direct and indirect HRQoL measurements in children following pediatric intensive care unit (PICU) admission. We collected Health Utilities Index 3 (HUI-3) and Visual Analog Scale (VAS) ratings of children who were urgently admitted to the PICU of a university-affiliated pediatric hospital at ICU admission (baseline) and one month post-ICU admission. The mean (SD) VAS converted standard gamble and HUI-3 utilities were 0.82 (±0.19) and 0.70 (±0.39), respectively, at baseline ( n = 51), and 0.81 (±0.15) and 0.58 (±0.39) at one month ( n = 36). The VAS utilities were significantly greater than the HUI-3 utilities ( p = 0.009). At baseline, the intraclass coefficient (95% confidence interval) was 0.49 (0.25–0.68), representing moderate agreement, and at one month, was 0.18 (−0.87 to 0.45), representing negligible agreement. There were significant differences between indirect and direct measures, and inconsistent agreement between utilities derived from the two measures. These data illustrate the potential impact of HRQoL assessment techniques on economic analyses used to inform health policy decision-making for pediatric critical care.
Prospective study of injury severity scores during a season of British Superbike racing
Authors: O’Dowd DP , Robertshaw S , Walker A , Roberts DG , Romer H 
Published: August 2013

Background: Motorbike racing is considered by many to be a dangerous sport, but there are little data within the literature to support this view. The purpose of this study was to determine the injury severity scores of injured riders in order to assess injury severity in elite level motorbike racing. Methods: Injury data were prospectively collected from all riders who attended the circuit medical centres at all rounds of the 2011 British Superbike Season. Abbreviated injury score and injury severity score were calculated for each rider and recorded along with other rider demographics. Results: A total of 259 riders presented to the circuit medical centres with injuries during the 2011 season. They suffered 382 injuries between them, with one fatality. The median injury severity score was 1 (mean 3.28, range 1–48, SD 5.08). Of the 1010 fallers during the season, only 33 (3.3%) required acute hospital admission. Conclusion: Greater than 93% of injured riders had injuries with an injury severity score ≤ 8 which is likely related to the high degree of protective clothing worn and safety measures at circuits including air fencing. The injury severity scores presented here for motorbike racing are less than or comparable to those seen in other physical sports such as elite level horse riding.
RCircos: an R package for Circos 2D track plots
Authors: Zhang Hongen , Meltzer Paul , Davis Sean 
Published: August 2013

Abstract

Background
Circos is a Perl language based software package for visualizing similarities and differences of genome structure and positional relationships between genomic intervals. Running Circos requires extra data processing procedures to prepare plot data files and configure files from datasets, which limits its capability of integrating directly with other software tools such as R. Recently published R Bioconductor package ggbio provides a function to display genomic data in circular layout based on multiple other packages, which increases its complexity of usage and decreased the flexibility in integrating with other R pipelines.

Results
We implemented an R package, RCircos, using only R packages that come with R base installation. The package supports Circos 2D data track plots such as scatter, line, histogram, heatmap, tile, connectors, links, and text labels. Each plot is implemented with a specific function and input data for all functions are data frames which can be objects read from text files or generated with other R pipelines.

Conclusion
RCircos package provides a simple and flexible way to make Circos 2D track plots with R and could be easily integrated into other R data processing and graphic manipulation pipelines for presenting large-scale multi-sample genomic research data. It can also serve as a base tool to generate complex Circos images.