bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circadian Alignment, Cardiometabolic Disease, and Sex-Specific Differences in Adults With Overweight/Obesity
Authors: Shafer Brooke M , Kogan Sophia A , Rice Sean P M , Shea Steven A , Olson Ryan , McHill Andrew W 
Published: August 2024

Abstract

Context
Circadian disruption promotes weight gain and poor health. The extent to which sex plays a role in the relationship between the circadian timing of behaviors and health outcomes in individuals with overweight/obesity is unclear.

Objective
We investigated the sex-specific associations between circadian alignment and cardiometabolic health markers in females and males with overweight/obesity.

Methods
Thirty volunteers with overweight/obesity (15 female; body mass index ≥25.1 kg/m2) underwent an evening in-laboratory assessment for dim-light melatonin onset (DLMO), body composition via dual energy x-ray absorptiometry, and a fasted blood sample. Circadian alignment was determined as the time difference between DLMO and average sleep onset over 7 days (phase angle), with participants categorized into narrow/wide phase angle groups based on median phase angle split. Due to known differences in metabolic markers between sexes, participants were subdivided based on sex into narrow and wide phase angle groups.

Results
Males in the narrow phase angle group had higher android/gynoid body fat distribution, triglycerides, and metabolic syndrome risk scores, while females had higher overall body fat percentage, glucose, and resting heart rates (all P &lt; .04). Furthermore, a narrower phase angle in males was negatively associated with android/gynoid body fat (r = −0.53, P = .04) and negatively associated with body fat (r = −0.62, P = .01) and heart rate (r = −0.73, P &lt; .01) in females.

Conclusion
Circadian disruption may not only promote a trajectory of weight gain but could also contribute to negative health consequences in a sex-dependent manner in those already with overweight/obesity. These data may have implications for clinical utility in sex-specific sleep and circadian interventions for adults with overweight/obesity.
The Comparison of Partial Hemivertebrae Resection Versus Total Hemivertebrae Resection in Children With Congenital Scoliosis
Authors: Alonge Emmanuel , Zhang Gengming , Zhang HongQi , Guo Chaofeng , Ang Deng 
Published: August 2024

BACKGROUND AND OBJECTIVES:
The surgical intervention for hemivertebra removal is complex, leading to a lack of a definitive solution. We aim to compare the clinical efficacy of less invasive, partial hemivertebra resection vs total hemivertebra resection in children.

METHODS:
Between 2011 and 2016, a retrospective study was conducted on a cohort of 43 patients diagnosed with congenital scoliosis coexisting with hemivertebrae. This study evaluated the outcomes of a posterior-only surgical approach, dividing the cohort into 2 groups based on the surgical technique applied: 23 patients underwent total hemivertebrae resection (TR), whereas 20 patients received partial hemivertebrae resection (PR), accompanied by short-segment fusion.

RESULTS:
There were 43 patients with congenital scoliosis associated with hemivertebrae in both the PR and TR groups. The average age at the time of surgery was 6.3 ± 2.0 years for the PR group and 6.0 ± 1.9 years for the TR group. The PR group exhibited a comparable correction rate of the Cobb angle at postoperation (4.3 ± 4.9 and 2.2 ± 3.2, P = .174) and the last follow-up (7.8 ± 1.3 and 5.5 ± 2.3, P = .113) compared with the TR group.

CONCLUSION:
Partial hemivertebra resection is efficient and secure. A less invasive technique obtained an equivalent, well-maintained correction rate to the total hemivertebra resection. However, this is the initial result, and the patients continue to be followed; we will await the results of the outcome at full-growth sprouts.
Robotic Resection of Spinal and Paraspinal Tumors
Authors: Barzilai Ori , Goh Alvin C. , Park Bernard , Rusch Valerie , Weiser Martin , Leitao Mario M. , Reiner Anne S. , Newman William Christopher , Bilsky Mark H. 
Published: August 2024

BACKGROUND AND OBJECTIVES:
Robotic arm surgical systems provide minimally invasive access and are commonly used in multiple surgical fields, with limited application in neurosurgery. Our institutional experience has led us to explore the benefits of a neurosurgeon trained to perform robotic surgery as part of a multidisciplinary team. The objective of this study is to evaluate the feasibility, safety, and outcomes of robotic resection for spinal nerve sheath tumors (NST).

METHODS:
Retrospective case series of robotic-assisted intracavitary approaches and resection of NSTs including thoracic, retroperitoneal, and transperitoneal. Surgical outcomes are compared to a historical cohort of open surgical resection of NSTs.

RESULTS:
Nineteen cases presented, of which 2 were combined posterior spinal followed by robotic tumor resection. One of 19 cases was converted to an open surgery. Gross total resection was achieved in all cases. There were 2 cases of postoperative Horner's syndrome, and 1 case with an intraoperative durotomy that was repaired primarily with no postoperative sequelae. Median estimated blood loss was 50 cc (range: 5-650) and median length of stay was 1 day (range: 0-6), with 9 (47.4%) patients discharged on postoperative day 1 and 3 (15.8%) patients discharged on an outpatient basis. Compared with our previously reported institutional outcomes for open resection of 25 tumors, there was a significant increase in rates of gross total resection (100 vs 60%, P = .002) and decrease in length of stay (median 1 vs 5 days, P < .0001).

CONCLUSION:
Robotic resection of complex paraspinal tumors appears safe and effective including for preservation of neurological function and may reduce surgical morbidity. Integration of robotic surgical platforms holds the potential to significantly affect neurological surgery.
The Temporal Effects of Altitude and Low Energy Availability Manipulation on Resting Metabolic Rate in Female Race Walkers
Authors: KUIKMAN MEGAN A. , MCKAY ALANNAH K. A. , MCCORMICK RACHEL , TEE NICOLIN , VALLANCE BRENT , ACKERMAN KATHRYN E. , HARRIS RACHEL , ELLIOTT-SALE KIRSTY J. , STELLINGWERFF TRENT , BURKE LOUISE M. 
Published: August 2024

ABSTRACT

Purpose
This study aimed to investigate the temporal effects of ~1800 m altitude exposure and energy availability (EA) manipulation on resting metabolic rate (RMR).

Methods
Twenty elite female race walkers underwent a 3-wk training camp at an altitude of ~1800 m. During the first 2 wk, athletes consumed a high EA (HEA) diet of 45 kcal·kg fat-free mass (FFM)−1·d−1. During the final week, half the athletes consumed a low EA (LEA) diet of 15 kcal·kg FFM−1·d−1, whereas the others continued on an HEA diet. Athletes followed individualized training plans throughout the study. To assess the effect of altitude on RMR, athletes in the HEA group had RMR measured at baseline (~580 m) before altitude exposure (Pre-alt), at 36 h (36h-alt), 2 wk (Wk2-alt), and 3 wk into altitude exposure (Wk3-alt), and at 36 h post-altitude exposure at ~580 m (36h-post). To assess the effect of LEA exposure on RMR while at altitude, athletes in the LEA group underwent RMR measurements at Pre-alt and before (Wk2-alt) and after the 7 d of LEA (Wk3-alt).

Results
Compared with Pre-alt, the RMR of HEA athletes was increased at 36h-alt (+5.3% ± 3.1%; P = 0.026) and Wk2-alt (+4.9% ± 4.9%; P = 0.049), but was no longer elevated at Wk3-alt (+1.7% ± 4.2%; P = 0.850). The RMR of HEA athletes at 36h-post was lower than all timepoints at altitude (P < 0.05) but was not different from Pre-alt (−3.9% ± 7.2%; P = 0.124). The 7-d period of LEA exposure at altitude did not affect RMR (P = 0.347).

Conclusions
RMR was transiently increased with ~1800-m altitude exposure in female athletes and was unaffected by short-term LEA. However, the altitude-induced increase was small (~25–75 kcal·d−1) and was unlikely to have clinically significant implications for daily energy requirements.
Quality of life among adults with scabies: A community-based cross-sectional study in north-western Ethiopia
Authors: Yirgu Robel , Middleton Jo , Cassell Jackie A. , Bremner Stephen , Davey Gail , Fekadu Abebaw 
Published: August 2024

Introduction
Scabies undermines quality of life through its highly disturbing disease symptoms, by distorting self-perception, and secondary to social stigma. Knowledge of its effect on quality of life in general and on specific aspects of day-to-day life is key to addressing the health needs of individual patients and to evaluating gains from community-based disease control interventions.

Objectives
To measure the effect of scabies on the quality of life of people with the infestation.

Methods
A community-based cross-sectional study was conducted in a scabies outbreak-affected district in north-western Ethiopia. The study involved 381 households and 86 adults with scabies. We used the ten-item Cardiff Dermatology Life Quality Index (DLQI) tool to collect data. Cronbach’s alpha value was used to determine the internal consistency of the Amharic version of the scale. Overall and Dermatology Life Quality (DLQ) domain specific mean scores were calculated. The association between sociodemographic characteristics and scabies-related life quality impairment was tested using Kruskal-Wallis test.

Results
Scabies moderately affected the quality of life of adults with scabies. The overall mean DLQI (mDLQI) score was 9.2 (SD = 7.6). ‘Symptoms and feelings’ and ‘daily activity’ DLQ domains had the highest mDLQI scores (3.5, SD = 1.9 and 2.2, SD = 2.5, respectively). ‘Leisure activities’ was the least affected domain 0.8 (SD = 1.1). In terms of severity, scabies had moderate or severe effect on DLQ of 54.7% of the participants and extremely severe effect was reported among 27% of the participants. However, no association was observed between sociodemographic characteristics and quality of life impairment.

Conclusion
Quality of life was moderately impaired among people affected by scabies. Refocusing attention on management of disease symptoms, using standard scabies treatment, and providing psychosocial support to improve self-perception of people affected with scabies may help reduce quality of life impairment.
Feasibility and reliability of online vs in-person cognitive testing in healthy older people
Authors: Morrissey Sol , Gillings Rachel , Hornberger Michael 
Published: August 2024

Background
Early evidence in using online cognitive assessments show that they could offer a feasible and resource-efficient alternative to in-person clinical assessments in evaluating cognitive performance, yet there is currently little understanding about how these assessments relate to traditional, in-person cognitive tests.

Objectives
In this preliminary study, we assess the feasibility and reliability of NeurOn, a novel online cognitive assessment tool. NeurOn measures various cognitive domains including processing speed, executive functioning, spatial working memory, episodic memory, attentional control, visuospatial functioning, and spatial orientation.

Design
Thirty-two participants (mean age: 70.19) completed two testing sessions, unsupervised online and in-person, one-week apart. Participants were randomised in the order of testing appointments. For both sessions, participants completed questionnaires prior to a cognitive assessment. Test-retest reliability and concurrent validity of the online cognitive battery was assessed using intraclass correlation coefficients (ICCs) and correlational analysis, respectively. This was conducted by comparing performance in repeated tasks across testing sessions as well as with traditional, in-person cognitive tests.

Results
Global cognition in the NeurOn battery moderately validated against MoCA performance, and the battery demonstrated moderate test-retest reliability. Concurrent validity was found only between the online and paper versions of the Trail Making Test -A, as well as global cognitive performance between online and in-person testing sessions.

Conclusions
The NeurOn cognitive battery provides a promising tool for measuring cognitive performance online both longitudinally and across short retesting intervals within healthy older adults. When considering cost-effectiveness, flexible administration, and improved accessibility for wider populations, online cognitive assessments show promise for future screening of neurodegenerative diseases.
CHRM3 (rs2165870) gene polymorphism is related to postoperative vomiting in female patients undergoing laparoscopic surgery. Prospective observational study
Authors: Cai Meng , Gan Lin , Li Jing , Lei Xiaofeng , Yu Jin 
Published: August 2024

Background
Postoperative nausea and vomiting are common complications after surgery, and female patients are more likely to experience these adverse events. The goal of this study was to explore the relationship between the CHRM3 rs2165870 polymorphism and postoperative vomiting incidence in female patients who underwent laparoscopic surgery.

Methods
Two hundred female patients who underwent elective laparoscopic surgery with subsequent patient-controlled intravenous analgesia using dexmedetomidine and sufentanil were prospectively enrolled. The CHRM3 rs2165870 and KCNB2 rs349358 polymorphisms were genotyped using MassARRAY SNP typing technology. Demographic data and preoperative laboratory results of all patients were recorded. Postoperative analgesia-related information, incidence of postoperative nausea and vomiting, and other adverse events were followed up and recorded for analysis.

Results
No significant differences were observed in any of the demographic characteristics of these patients among the different genotype carriers (P>0.05). The percentages of patients with each genotype of CHRM3 were 67% (GG), 28.5% (GA) and 4.5% (AA). We found that the AA or A allele of the CHRM3 rs2165870 polymorphism elevated the risk of postoperative vomiting (AA versus GG; OR, 6.94; 95% CI, 1.49–32.46; P = 0.014; A versus G; OR, 2.52; 95% CI, 1.22–5.19; P = 0.012). The percentages of patients with each genotype of KCNB2 were 84.5% (TT), 15.5% (CT) and 0% (CC). There were no significant differences in the postoperative nausea or vomiting rate across the KCNB2 rs349358 polymorphisms (P>0.05).

Conclusion
The CHRM3 rs2165870 polymorphism is associated with the occurrence of postoperative vomiting in female patients who have undergone laparoscopic surgery. The AA genotype or A allele of the CHRM3 rs2165870 polymorphism elevates the risk of postoperative vomiting.

Trial registration
www.chictr.org.cn, registration number: ChiCTR2200062425.
On the construal of MUSIC IS MOTION metaphor
Authors: Wu Jingfang , Liu Yuhong 
Published: August 2024

Abstract
TIME IS MOTION can be construed in two models. One is the Ego-based, the other is Time-based so as to form three time metaphors, MOVING TIME, TIME’S LANDSCAPE, and TEMPORAL SEQUENCE. When construing musical motion, people tend to borrow this conceptual framework and get three musical metaphors, i.e. MOVING MUSIC, MUSICAL LANDSCAPE, and MUSICAL SEQUENCE. The MUSICAL SEQUENCE metaphor falls into three categories, i.e. SEQUENCE IS THE RELATIVE POSITION ON THE TIME PATH, ON THE PITCH PATH, and ON THE KEY PATH. Time Metaphor and the Event Structure Metaphor jointly construct the two construal models for the metaphor MUSIC IS MOTION. This study tries to validate the previous research on conceptual construals in such a new field as music so as to enlarge the research range of the conceptual metaphor theory and provide reference for the subsequent research on music.
The accumulation of cadmium in poplar trees during three consecutive years
Authors: Cheng Bixin , Rong Gong , Ying Siya , Kong Suming , Chu Yin , Liu Shengquan 
Published: August 2024

Abstract
A three-year pot experiment was designed to investigate cadmium (Cd) accumulation in the various parts of poplar (Populus deltoides Bartr. cv. ‘Lux’ I-69/55) by setting up 5 Cd application treatments (0, 5, 20, 50, and 100 mg/kg dry soil). The results showed that poplar exhibited a high tolerance to Cd stress, with Cd uptake significantly increasing across all plant parts as soil Cd levels rose. In general, leaves exhibited the highest Cd concentration while stems had the lowest. An upward increase trend of the accumulation of Cd in the aboveground parts from the base wood, along the stem to the branch, until the leaves, as well as a radially outward increase of Cd from the wood near the pith, to the wood near the bark, and finally to the bark, were observed. Over the three successive years, poplar trees exhibited a generally increasing extraction ability in terms of Cd concentration and the bioconcentration factor (BCF) in their aboveground parts, attributed to the enhanced leaf transpiration and conducting tissue development. The BCFs of various parts of poplar ranged from 0.09 to 6.30, following the trend of leaf > bark > branch > root > stem.
Empagliflozin improves aortic injury in obese mice by regulating fatty acid metabolism
Authors: Yue Lin , Wang Yue , Wang Cuiying , Niu Shu , Dong Xihong , Guan Yaqing , Chen Shuchun 
Published: August 2024

Abstract

Background
Empagliflozin has been shown in clinical studies to lower the risk of adverse cardiovascular events. Using proteomics, the current study aims to determine whether empagliflozin reduces aortic alterations in obese mice and to investigate its molecular mechanism of action.

Methods
We constructed obese mice and then treated them with empagliflozin. Changes in the weight of the mice were recorded. Blood glucose and lipid levels were measured in each group of mice, and changes in pulse wave velocity and aortic structure were recorded. In addition, changes in aortic protein expression were detected by proteomics and analyzed bioinformatically.

Results
Proteomics results showed that 507 differentially expressed proteins (DEPs) were identified in the comparison of normal and obese mice, while 90 DEPs were identified in the comparison of obese and empagliflozin-treated mice. Examination of these three groups revealed that DEPs were largely associated with the digestion of unsaturated fats. Among them, empagliflozin significantly reduced the expression of fatty acid synthase (FASN), acyl-CoA desaturase 3 (SCD3), ACSL1. and ACSL5 in the aorta of obesity-induced mice, and there was a close relationship between the four.

Conclusion
Empagliflozin reduced the protein expression of FASN, SCD3, ACSL1, and ACSL5 in the aorta of obese mice and improved aortic fatty acid metabolism and reduced vascular stiffness for vasoprotective effects.
The crystal structure of (Z)-5-amino-N
′-hydroxy-1H-pyrazole-4-carboximidamide, C4H7N5O
Authors: Li Yunlu , Han Lujing , Wang Bo , Mu Sitong 
Published: August 2024

Abstract
C4H7N5O, monoclinic, P21 (no. 4), a = 4.855(3) Å, b = 9.026(5) Å, c = 7.092(4) Å, β = 103.267(7)°, V = 302.5(3) Å3, Z = 2, R

gt
(F) = 0.0369, wR

ref
(F
2) = 0.0960, T = 296 K.
Removal of metaldehyde pesticide from aquatic media using modified cellulose obtained from Populus nigra plant, as potential adsorbent
Authors: Said Gulab , Ahmad Waqas , Jan Muhammad Tariq , Zahoor Muhammad , Ullah Azmat , Ullah Riaz , Umar Muhammad Naveed , Iqbal Zafar , ur Rashid Haroon 
Published: August 2024

Abstract
In this study modified cellulose based adsorbent was prepared from Populus nigra plant, and used for elimination of metaldehyde (herbicide) from model waste water. The adsorbent was characterized through analytical technique such as FTIR, SEM, EDX and XRD for structural adsorption related parameters. The results of SEM showed the suitability of the material to be used as adsorbent and FTIR showed successful crosslinking of polyvinyl alcohol into cellulose structure. In order to get maximum reclamation benefits from adsorbent it was subjected to a number of tests evaluating the effect of metaldehyde concentration, sorbent dose, contact time, initial pH of solution and temperature. The maximum removal of 70 % was achieved under conditions of 80 mg/L metaldehyde concentration, 60 min contact time, pH of 8, 0.08 g sorbent dosage, and room temperature (25 °C). The Langmuir isotherm model with correlation coefficients of 0.9855 and maximum adsorption capacity recorded was 8.32 mg/g, while excellent agreement was shown by kinetic data with pseudo second order kinetic model with R
2 = 0.9876. Thermodynamic study indicated enthalpy change (ΔH° = −129 kJ/mol) to be negative, entropy change (ΔS° = 161.7 j/mol) positive, and the Gibbs free energy (ΔG) as negative showing that the process to be exothermic and feasible/spontaneous with an increase of randomness at solid liquid interface. The finding indicated that modified cellulose could be used as an efficient adsorbent for removal of metaldehyde from model waste water. However, further validation with other pollutants will be helpful in checking reproducibility of the present findings.
Factors influencing vowel adaptation in English loanwords in Korean
Authors: Cho Mi-Hui , Lee Shinsook 
Published: August 2024

Abstract
This study explores the extent to which perceptual and other factors (i.e., orthography and standardization) affect vowel adaptation in English loanwords in Korean. It also examines whether perceptual variability gives rise to adaptation variability, and it further addresses whether the degree of perceptual influence in vowel adaptation is different from that in consonant adaptation. Data on Korean listeners’ perceptual mapping patterns for English vowels were collected in an English-to-Korean vowel category mapping experiment and compared to the patterns in a loanword database. The results indicate that perceptual factors have a great impact on the adaptation of English vowels into Korean, in line with de Jong and Cho’s (de Jong, Kenneth & Mi-Hui Cho. 2012. Loanword phonology and perceptual mapping: Comparing two corpora of Korean contact with English. Language 88. 341–368) findings for the adaptation of English consonants into Korean. Consequently, factors such as orthography and standardization are viewed as deviations from these perceptual influences. The impact of perceptual adaptation is, however, rather limited because the correlation between perceptual mappings and loanword mappings is less robust for English vowel adaptation than for English consonant adaptation possibly due to the less categorical nature of vowels relative to consonants. Additionally, the results show that increased strength of modal perceptual mappings is related to less loanword variability in vowel adaptation.
Late progression of renal cell carcinoma after 32 years: clinical case
Authors: Petrov L. O. , Izmailov A. A. , Ustimenko A. V. , Kalpinskiy A. S. , Izmailov A. A. , Alekseev B. Ya. , Ivanov S. A. 
Published: August 2024

In 2022, renal cell carcinoma was the 10th (3.9 %) most common cancer in the Russian Federation. According to the World Health Organization, in 2020 431,288 new cases of kidney cancer were detected worldwide, and by 2040 the incidence will increase up to 605,726 cases. Local recurrence of the disease develops in 1.8–14.6 % of patients with localized and locally advanced kidney cancer who underwent radical nephrectomy. Surgery, if technically possible, is the gold standard for the treatment of patients with solitary or single (≤2) metastases of any location, and in most cases, it requires aggressive tactics.Many large randomized trials have investigated adjuvant therapy using targeted drugs for renal cell carcinoma but no statistically significant differences in risk of death and progression irrespective of the drugs used or treatment duration has been shown. Currently, only the KEYNOTE-564 randomized trial has demonstrated an increase in recurrencefree survival in patients with intermediate-high and high risk renal cell carcinoma.The article presents a clinical case of late progression of renal cell carcinoma in extraperitoneal lymph nodes 32 years after combination treatment (radical nephrectomy + external beam radiotherapy on the bed of the resected kidney).