bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimentelle Untersuchungen zum Einfluss von Geogittern in ungebundenen Tragschichten
Authors: Bräunig Claudia , Herle Ivo , Weisemann Ulrike 
Published: August 2024

AbstractIm Bahnbau werden meist Tragschichten aus ungebundenem grobkörnigem Material zwischen dem anstehenden Untergrund und der Schotterbettung eingebaut. Diese können zusätzlich verstärkt werden. Dazu werden Geokunststoffe, insbesondere Geogitter, eingesetzt, um das Trag‐ und Systemverhalten zu verbessern. Die bisherige Reduzierung der Tragschichtdicke infolge der Geogittereinlage folgt empirischen Ansätzen. Mittels experimenteller Untersuchungen soll der Einfluss des Geogitters auf das Tragverhalten einer Tragschicht quantifiziert werden. Die Untersuchung erfolgt anhand eines skalierten Aufbaus des Tragschicht‐ und Geogittermaterials. Es wurden sowohl monotone als auch zyklische Triaxialversuche durchgeführt, um zum einen das Verhalten bis zum Bruchzustand und zum anderen das Verhalten unter zyklischen Lasten abzubilden. Bei den monotonen Triaxialversuchen wurden die Probekörper bis zum Bruch abgeschert. Hierbei konnte der positive Einfluss der Geogitter im Vergleich zu den unbewehrten Probekörpern quantifiziert werden. Da die In‐situ‐Beanspruchungen überwiegend im Gebrauchslastbereich liegen und somit der Versagenszustand nicht erreicht wird, jedoch die Beanspruchung einer hohen Lastwechselanzahl folgt, wurden zyklische Triaxialversuche angeschlossen. Dabei wurden die Probekörper zyklisch belastet, um den Einfluss des Geogitters auf die Verformungsakkumulation zu untersuchen. Im Ergebnis konnte eine Reduzierung der Verformungsakkumulation durch das Geogitter nachgewiesen werden.
Confirmatory analysis of the 13‐MD and ranking of its meta‐dimensions and items
Authors: Touré Moustapha , Poder Thomas G. 
Published: August 2024

AbstractBackgroundThe 13‐MD is a new generic instrument developed to measure general health‐related quality of life (GHRQoL). This instrument considers all aspects of health (i.e., physical, mental, and social) in a balanced way. A previous study led to minor changes in the original version of the 13‐MD. The objective of this study was to confirm the validity of the modified 13‐MD.MethodsValidity was assessed with recent data from the general population of Quebec, Canada. The meta‐dimensions and items composing the 13‐MD were also subjected to a ranking procedure, which allowed to determine the most important aspects for respondents.ResultsA total of 1337 French‐speaking participants were recruited with 1099 completing the 13‐MD for validation purposes and 1084 completing the ranking procedure. The 13‐MD showed very satisfactory results and confirmed to be a valid instrument. The ranking of the meta‐dimensions revealed that “Well‐being” received the most points, followed by “Sleep and energy” and “Body functioning.”ConclusionThese results will be very useful in the continuous improvement of the 13‐MD, ultimately leading to the valuation stage (i.e., development of a value set).
Maternal antenatal depression, oxytocin, and infant temperament: The roles of ethnicity and adult attachment avoidance
Authors: Kohlhoff Jane , Karlov Lisa , Dadds Mark , Barnett Bryanne , Silove Derrick , Eapen Valsamma 
Published: August 2024

AbstractThis study examined the associations between maternal depression and oxytocin in pregnancy, caregiving sensitivity and adult attachment style, and infant temperament. One hundred and six women recruited from a public hospital antenatal clinic in Australia, and their infants completed assessments at three time points (Time 1: pregnancy; Time 2: 3‐month postpartum; Time 3: 12‐month postpartum). Mothers completed self‐report questionnaires assessing maternal depression symptom severity at Time 1–3, adult attachment style at Time 2, and infant temperament at Time 3. At Time 1, they also provided a blood sample to assess peripheral oxytocin levels, and at Time 2, participated in a parent–child interaction session, which was later coded for caregiving behavior (sensitivity). Neither maternal depression nor lower levels of oxytocin during pregnancy predicted difficult infant temperament; rather, it was predicted by non‐Caucasian ethnicity. When all other variables were free to vary, adult attachment avoidance mediated an association between maternal depression during pregnancy and difficult infant temperament. Results highlight the potential value of interventions focusing on adult attachment insecurity for pregnant women and raise questions about associations between culture/ethnicity and infant temperament.
Embedded system controlled switching system for reconfigurable antennas
Authors: Kumar Naresh , Kumar Pradeep , Sharma Manish 
Published: August 2024

AbstractA multiband and reconfigurable antenna is the one of the main aspects in the communication system which has an extremely important role. An embedded based solution for the fast operation of a reconfigurable antenna to work in a specific operating frequency band is the solution of future technologies. Embedded based solution increases the speed by avoiding the dependence on manual control of the RF switching elements. In this paper, the proposed embedded system‐controlled switching mechanism operate the reconfigurable antenna in any one of the operating bands by a single command to be send from a remote location. The embedded system receives the command and configure a set of PIN diodes as per the modes. The proposed solution consists an Arduino UNO board as motherboard, SIM900A as GSM module to receive the command from user, biasing circuit to control the operation of PIN diode, PIN diode to reconfigure the patch pattern and a user mobile for sending AT command.The proposed model is successful and tested on proteus software 8.0. The model is also deployed on the newly designed multiple‐input‐multiple‐output antenna where the result shows the successful operation to achieve multiband frequency operation.
Dancing with BBoy: Transliteracies and critical imagination in superhero storytelling
Authors: Krone Beth , Enciso Patricia 
Published: August 2024

AbstractIn this article, we describe a year‐long superhero storytelling project we facilitated with youth in a midwestern middle school. In this project, students read Miles Morales: The Ultimate Spiderman , designed superhero stories set in their community, and presented artistic representations of their stories to their families and peers. We present three episodes of mobile storytelling from this project, focusing on Aidan, one of eighteen youth participants. Using tools from theories of transliteracies and critical imagination, we illustrate how Aidan's embodied movement and play constituted critically literate acts. A transliteracies lens oriented toward critical imagination reveals how Aidan fluidly moved between fictional and real worlds to reimagine his experienced realities. These findings indicate a need to expand what counts as literate activity in schools.
Sexual color ornamentation, microhabitat choice, and thermal physiology in the common wall lizard (Podarcis muralis)
Authors: Ruiz Miñano Maravillas , Uller Tobias , Pettersen Amanda K. , Nord Andreas , Fitzpatrick Luisa J. , While Geoffrey M. 
Published: August 2024

AbstractCommon wall lizards (Podarcis muralis) in Italy show a striking variation in body coloration across the landscape, with highly exaggerated black and green colors in hot and dry climates and brown and white colors in cool and wet climates. Males are more intensely colored than females, and previous work has suggested that the maintenance of variation in coloration across the landscape reflects climatic effects on the strength of male–male competition, and through this sexual selection. However climatic effects on the intensity of male–male competition would need to be exceptionally strong to fully explain the geographic patterns of color variation. Thus, additional processes may contribute to the maintenance of color variation. Here we test the hypothesis that selection for green and black ornamentation in the context of male–male competition is opposed by selection against ornamentation because the genes involved in the regulation of coloration have pleiotropic effects on thermal physiology, such that ornamentation is selected against in cool climates. Field observations revealed no association between body coloration and microhabitat use or field active body temperatures. Consistent with these field data, lizards at the extreme ends of the phenotypic distribution for body coloration did not show any differences in critical minimum temperature, preferred body temperature, temperature‐dependent metabolic rate, or evaporative water loss when tested in the laboratory. Combined, these results provide no evidence that genes that underlie sexual ornamentation are selected against in cool climate because of pleiotropic effects on thermal biology.
A comprehensive gas chromatography electron ionization high resolution mass spectrometry study of a new steroidal selective androgen receptor modulator (SARM) compound S42
Authors: Wen Hui‐Chung , Wilczek Tobias , Neudörfl Jörg‐M. , Wagener Felicitas , Piper Thomas , Thevis Mario , Schäfer Mathias 
Published: August 2024

AbstractThe synthetic 20‐keto‐steroid S42 (1) demonstrated selective androgen receptor modulator (SARM) properties in preclinical studies and, consequently, received growing attention also in the context of sports drug testing programs. Fundamental understanding of the behavior of S42 (1) and of relevant derivatives in gas chromatography‐electron ionization MS experiments at high resolution (GC‐EI‐HRMS) is indispensable to develop a reliable qualitative and quantitative doping control method for S42 (1) and its metabolites in body fluid matrices. We present important fundamental mechanistic data on the EI fragmentation behavior of S42 (1) and of silyl ether derivatives as well as of stable isotope‐labelled reference material.
The career and mental health experiences of Black women in STEM
Authors: Cabell Autumn L. , Brookover Dana 
Published: August 2024

AbstractBlack women are underrepresented in science, technology, engineering, and mathematics (STEM) industries and are presented with unique career and mental health experiences as a result. This study used social cognitive career theory and thematic analysis to explore the career and mental health experiences of (N = 11) Black women in STEM. The findings include four themes: (1) the influence of a STEM career on mental health; (2) the STEM career journey; (3) self‐efficacy and self‐motivation to succeed; and (4) hopes for Black girls and women in STEM. Implications for counselors who work with Black women in STEM are discussed.
Meta‐analyses of phase I dose‐finding studies: Application for the development of protein kinase inhibitors in oncology
Authors: Caquelin Laura , Badra Pauline , Poulain Lucas , Laviolle Bruno , Ursino Moreno , Locher Clara 
Published: August 2024

AbstractThis study aimed to assess the feasibility of applying two recent phase I meta‐analyses methods to protein kinase inhibitors (PKIs) developed in oncology and to identify situations where these methods could be both feasible and useful. This ancillary study used data from a systematic review conducted to identify dose‐finding studies for PKIs. PKIs selected for meta‐analyses were required to have at least five completed dose‐finding studies involving cancer patients, with available results, and dose escalation guided by toxicity assessment. To account for heterogeneity caused by various administration schedules, some studies were divided into study parts, considered as separate entities in the meta‐analyses. For each PKI, two Bayesian random‐effects meta‐analysis methods were applied to model the toxicity probability distribution of the recommended dose and to estimate the maximum tolerated dose (MTD). Meta‐analyses were performed for 20 PKIs including 96 studies corresponding to 115 study parts. The median posterior probability of toxicity probability was below the toxicity thresholds of 0.20 for 70% of the PKIs, even if the resulting credible intervals were very wide. All approved doses were below the MTD estimated for the minimum toxicity threshold, except for one, for which the approved dose was above the MTD estimated for the maximal threshold. The application of phase I meta‐analysis methods has been feasible for the majority of PKI; nevertheless, their implementation requires multiple conditions. However, meta‐analyses resulted in estimates with large uncertainty, probably due to limited patient numbers and/or between‐study variability. This calls into question the reliability of the recommended doses.
Recurrence of fusocellular subtype GIST with SDHB mutation: A case of SDHB‐loss and therapeutic challenges
Authors: da Silva Gomes Samuel , Oliveira Carolina S. , Furtado Thiago de Almeida , Melo Lara M. , dos Santos Sara G. , Braga Renata S. N. , Martins Eduarda M. T. G. , Gomes João P. dos Santos 
Published: August 2024

AbstractGastrointestinal stromal tumors (GISTs) are sarcomas affecting the stomach and small intestine, with a rare subtype characterized by succinate dehydrogenase B (SDHB)‐loss posing significant diagnostic and therapeutic challenges. A 62‐year‐old man with weight loss and abdominal pain was diagnosed with a gastric GIST showing SDHB‐loss. Initial treatment with Imatinib reduced the tumor size, but surgery revealed no residual tumor. Despite adjuvant Imatinib, recurrence occurred, necessitating further surgical intervention. While GISTs typically benefit from surgery and tyrosine kinase inhibitors (TKIs), those with SDHB‐loss are resistant to TKIs, requiring a different management approach. This case emphasizes the importance of surgical intervention for SDHB‐deficient GISTs and the need for ongoing research into effective treatments for this subtype.
Advances from targeted therapy for non‐metastatic HER2‐positive inflammatory breast cancer
Authors: Steadman Jessica A. , Hieken Tina J. 
Published: August 2024

AbstractAmong inflammatory breast cancer (IBC) patients, over one‐third have HER2‐overexpressing (HER2+) tumors. Pathologic complete response (pCR) rates to neoadjuvant targeted and chemotherapy for patients with HER2+ non‐metastatic IBC now apporach 60% and favorable long‐term survival rates are being reported for those with a pCR. Immune mechanisms contributing to this phenomenon include antibody‐mediated immune activation and induction of memory T‐cell reponses which may explain the sustained antitumor response seen after discontinuation of targeted therapies.
Ultrasound Classification and Preoperative Ultrasound Diagnosis Analysis of Ovarian Ectopic Pregnancy
Authors: Lv Xiaoli , Yang Qing , Chen Yunqi , Ren Min , He Laman 
Published: August 2024

ObjectivesA classification system of ovarian ectopic pregnancies (OEP) could aid in their management. This study aimed to investigate the ultrasound classification and preoperative ultrasound diagnosis of OEP.MethodsThis retrospective case series study analyzed the clinical and ultrasound imaging data of 68 pregnant women diagnosed and confirmed with OEP at the Obstetrics and Gynecology Hospital affiliated with Tongji University between January 2015 and March 2023. The study focused on examining the ultrasound characteristics of different types of ovarian pregnancies and the accuracy of preoperative ultrasound diagnoses.ResultsThe study included 68 patients with a median age of 30 (22‐47) years. There were 43 cases (63.2%) of ruptured OEP and 25 (36.8%) of unruptured OEP. The unruptured cases were subclassified as embryonic sac type (n = 16) and heterogeneous mass type (n = 9). Preoperative ultrasound accurately diagnosed 19 cases (27.9%) of OEP, including 10 (62.50%) of the embryonic sac type, 4 (44.44%) of the heterogeneous mass type, and 5 (11.63%) of the ruptured type. Preoperative ultrasonography showed that embryonic sac type OEP was characterized by an intra‐ovarian cystic structure with a distinctive hyperechoic ring and, in some cases (8 out of 16), the presence of embryonic buds and/or yolk sacs. Ruptured OEP was characterized by mixed masses in the pelvic cavity with minimal or significant free pelvic fluid, an unclear boundary between the mass and the ovary, and limited or no vascularity.ConclusionsUltrasound may be used to determine the type of OEP preoperatively, with a higher diagnostic yield for the embryonic sac subtype. Preoperative ultrasonographic classification may enhance the preoperative diagnosis of OEP.
Enhancing therapeutic potential: Human adipose‐derived mesenchymal stem cells modified with recombinant adeno‐associated virus expressing VEGF165 gene for peripheral nerve injury
Authors: Jiang Shuai , Chen Bo , Sun Zhen‐Yu 
Published: August 2024

AbstractThis study aimed to investigate the therapeutic potential of human adipose‐derived mesenchymal stem cells (hADSCs) modified with recombinant adeno‐associated virus (rAAV) carrying the vascular endothelial growth factor 165 (VEGF165) gene in peripheral nerve injury (PNI). The hADSCs were categorized into blank, control (transduced with rAAV control vector), and VEGF165 (transduced with rAAV VEGF165 vector) groups. Subsequently, Schwann cell differentiation was induced, and Schwann cell markers were assessed. The sciatic nerve injury mouse model received injections of phosphate‐buffered saline (PBS group), PBS containing hADSCs (hADSCs group), rAAV control vector (control‐hADSCs group), or rAAV VEGF165 vector (VEGF165‐hADSCs group) into the nerve defect site. Motor function recovery, evaluated through the sciatic function index (SFI), and nerve regeneration, assessed via toluidine blue staining along with scrutiny of Schwann cell markers and neurotrophic factors, were conducted. Modified hADSCs exhibited enhanced Schwann cell differentiation and elevated expression of Schwann cell markers [S100 calcium‐binding protein B (S100B), NGF receptor (NGFR), and glial fibrillary acidic protein (GFAP)]. Mice in the VEGF165‐hADSCs group demonstrated improved motor function recovery compared to those in the other three groups, accompanied by increased fiber diameter, axon diameter, and myelin thickness, as well as elevated expression of Schwann cell markers (S100B, NGFR, and GFAP) and neurotrophic factors [mature brain‐derived neurotrophic factor (BDNF) and glial cell‐derived neurotrophic factor (GDNF)] in the distal nerve segment. rAAV‐VEGF165 modification enhances hADSC potential in PNI, promoting motor recovery and nerve regeneration. Elevated Schwann cell markers and neurotrophic factors underscore therapy benefits, providing insights for nerve injury strategies.
Medial‐pivot design does not provide superior clinical results compared to posterior‐stabilized total knee arthroplasty despite kinematic differences during step‐up and lunge activities: A prospective randomized controlled trial under medial tight soft tissue balance
Authors: Nakamura Eiichi , Okamoto Nobukazu , Masuda Tetsuro , Hisanaga Satoshi , Yugami Masaki , Oniki Yasunari , Miyamoto Takeshi 
Published: August 2024

AbstractPurposeThis study aimed to compare in vivo kinematics during weight‐bearing daily activities and determine the relationship with clinical outcomes in patients undergoing total knee arthroplasty (TKA) with a medial‐pivot (MP, Evolution™) versus a posterior‐stabilized (PS, Persona®) design under constant conditions of intraoperative soft tissue balance.MethodsForty patients undergoing MP or PS‐TKA under similar conditions of soft tissue balance were enrolled in this prospective randomized controlled trial. Outcome measures included clinical knee society scores (KSS) and knee injury and osteoarthritis outcome scores (KOOS). A kinematic assessment was conducted while the participants performed lunge and step‐up activities under fluoroscopic guidance.ResultsEighteen patients in each arm completed 1‐year follow‐up and were included in the analysis. All patients experienced pain relief and satisfactory knee function postoperatively. In kinematics, in the MP arm, the medial femoral condyle remained consistent, whereas the lateral femoral condyle gradually shifted posteriorly with increasing knee flexion. Conversely, in the PS arm, paradoxical anterior movement of the medial femoral condyle accompanied the lateral pivot motion. During lunge and step‐up activities, a medial‐pivot motion was observed in 83% and 72% of knees in the MP arm, respectively, compared with 22% and 11% in the PS arm. Despite these differences in kinematics, there were no statistically significant differences in the KSS and KOOS between the two groups.ConclusionUnder weight‐bearing conditions during flexion, knees that underwent Evolution™ MP‐TKA did not show superior clinical results compared to Persona® PS‐TKA, despite exhibiting in vivo kinematics closely resembling the normal in vivo pattern.Level of EvidenceLevel I, therapeutic studies.
Grazing regimes alter the fate of 15N‐labeled urea in a temperate steppe
Authors: Tian Yuqiang , Wang Ruixue , Zhao Yan , Chen Xiaoxia , Li Xiaobing , Baoyin Taogetao , Su Zhaowen , Ouyang Shengnan 
Published: August 2024

AbstractClarifying the fate of different nitrogen (N) species in different pools of terrestrial ecosystems is a prerequisite for a comprehensive understanding of the influence of human activities on the N cycle. Grazing has always been an important way of grassland management for centuries in the temperate grasslands of North China. However, how grazing regimes affect the N fate of urea derived from the livestock in the plant–soil systems of grazed grasslands remains poorly understood. Therefore, an in situ three‐factor (grazing regime, soil depth, and sampling time) 15N‐labeling experiment in a temperate steppe was conducted to answer this question. After 48 days of 15N labeling, the 15N recovered in shoots under no grazing (7.3% ± 1.8%) was approximately 2.3 times of that under rotational (3.2% ± 0.4%) and 2.5 times of that under continuous overgrazing (2.9% ± 0.5%). More 15N was recovered in roots under rotational than continuous overgrazing (19.8% ± 2.4% vs. 10.4% ± 0.5%, respectively), indicating that rotational overgrazing could promote more N retention in the roots. However, the 15N recovered in the soil was lower under continuous (23.7% ± 2.0%) than that of no grazing (42.0% ± 5.6%). Additionally, overgrazing reduced the magnitude of the soil active N pool in microbial biomass N and soluble N relative to no grazing. The grazing regimes would have significantly influenced both the soil and plants. That is to say, grazing regimes have directly impacted plant growth, and subsequently indirectly affected soil properties. Overgrazing often led to excessive vegetation consumption, resulting in decreased soil water content (SWC) and reduced soil organic carbon (SOC), ultimately caused alterations in plant species composition. The retention of 15N within the plant–soil system under continuous overgrazing was notably lower compared to that of no grazing. Continuous overgrazing has led to a shift in the dominant plant species from Leymus chinensis to Stipa grandis, by decreasing the proportion of perennial grasses by 10%, and increasing the annual and biennial plants by 8%. The fate of 15N was also altered in response to the variations in grazing regimes. Consequently, the recovery of 15N within the plant–soil system under continuous overgrazing was significantly lower compared to that of no grazing. In conclusion, overgrazing reduces the recovery of 15N within the plant–soil system in the temperate steppe, and rotational grazing is more preferable over continuous grazing as it could promote higher N retention in grassland ecosystems.