bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Machine Repair Models With Multi-Threshold Synchronous Vacations
Authors: Wu Chia-Huang , Ke Jau-Chuan , Choudhury Gautam 
Published: April 2013

AbstractIn this paper, we present an analysis of a machine repair problem with M operating machines and S standbys, in which c repairmen are responsible for supervising these machines and follow a multi-threshold, synchronous vacation policy. With such a policy, at a repair completion instant, if the number of the failed machines in the system is less than a preset threshold value, partial idle servers together take a single vacation (or leave for a random amount of time doing other secondary job). At the end of a vacation, they return to repair the failed machines (or waits for the arrival). The steady-state probabilities are solved by using the matrix-analytic method, and formulae of system performance measures are thereby obtained. A cost model is then developed to formulate an optimization problem to find the minimum cost. The direct search and quasi-Newton methods are implemented to determine the optimal number of servers, the optimal threshold policy and the optimal repair rate.
Applying Hybrid Grey Models in Analyzing Tonnage Growth Trends in Bulk Shipping Among China, Hong Kong, and Taiwan
Authors: Chung Cheng-Chi 
Published: April 2013

Abstract
The development of bulk shipping is deeply affected by global economic prosperity or adversity. China, Hong Kong, and Taiwan (CH&T) are not only the main suppliers of bulk carriers (bulkers), but also the major trading countries or areas in the world. The development of deadweight tonnages (DWTs) in these areas will significantly influence global trade. This paper begins with the supply side, using the latest 15 years of statistics from the Institute of Shipping Economics and Logistics to analyze the current development status of the bulk shipping market among CH&T. Further, four GM(1,1) models of grey theory are adopted to analyze the developmental trends of bulkers. The results show that, not only has the DWTs of the world been increasing, but also that in CH&T in the past few years. Second, after China and Taiwan became members of the World Trade Organization, the number of flagging-out vessels has been increasing more rapidly than the number of national vessels. Moreover, it can be said that DWTs will increase in China and Taiwan, but decrease in Hong Kong in the coming three years in terms of the growth trend. These findings will assist bulk shipping companies in making operational strategies, and government authorities in formulating supportive shipping policies.
Pressure Distribution of Dynamic Water Penetration Tests for Curtain Walls
Authors: Lee Tai-Kuang , Kuo Chien-Yuan , Pan Austin D. E. , Li Yi-Chao 
Published: April 2013

Abstract
A wind generator is used for producing a wind stream equivalent to the required wind velocity pressure for dynamic water penetration tests for curtain walls. A two-phase experimental program was carried out. In the first stage, the calibration of the wind generator was conducted following AAMA 501.1-05 procedures. In the second stage, the dynamic pressure distribution on the surface of the test chamber for curtain walls was studied. Discussions of the experimental results are presented, as well as new design aids for curtain wall design. Some of the experimental results and conclusions could be useful in the future for comparisons between laboratories having similar electric-fan-based test systems.
Effect of Steel Fibers and Thermal Cycles on Fracture Properties of Ultra-High-Performance Concrete
Authors: Hakeem Ibrahim , Azad Abul K. , Ahmad Shamsad 
Published: April 2013

Abstract
The advent of ultra-high-performance concrete (UHPC), a new generation of cementitious material having excellent material properties, has generated a great deal of interest in the field. In this study, the fracture properties of UHPC mixtures reinforced with steel fiber (fiber content varying from 0 to 6.2 % by weight) and subjected to thermal cycles were investigated to examine the effect of heat–cool cycles. The standard prism of 100 × 100 × 400 mm3 with a central notch was used in a three-point bend test to determine fracture properties that include critical stress-intensity factor (Kic), critical crack tip opening displacement (CTODc), energy release rate, and total fracture energy. All specimens were water-cured for 28 days. Two exposure conditions were used: a 6-month thermal cycling and a 6-month laboratory exposure for further self-curing. The thermal cycling comprised heating in an oven at 60°C for 2 days and then cooling them at room temperature for the next 2 days over a period of 6 months. Test results show that UHPC reinforced with 6.2 % steel fiber exhibited excellent fracture properties with significant ductility. Both thermal cycling and prolonged self-curing of water-cured UHPC specimens enhance fracture properties because of more complete hydration of cement in UHPC. This improvement in properties signals an additional advantage of water-cured UHPC for its application in hot climatic conditions.
Association of Anthracycline-Related Cardiac Histological Lesions With NADPH Oxidase Functional Polymorphisms
Authors: Cascales Almudena , Pastor-Quirante Francisco , Sánchez-Vega Beatriz , Luengo-Gil Ginés , Corral Javier , Ortuño-Pacheco Guzmán , Vicente Vicente , Peña Francisco Ayala 
Published: April 2013

Abstract

Objective.
Treatment with anthracyclines may cause cardiac dysfunction, but the sequence of anthracycline-induced heart lesions has been incompletely characterized. NADPH oxidase, a key mediator of oxidative cardiac damage and remodeling, modulates anthracycline clinical cardiotoxicity. Our aim was to determine which cardiac histological lesions are specifically induced by anthracycline treatment and to investigate the role of NADPH functional genetic polymorphisms in their development.

Patients and Methods.
Using a retrospective case–control design, we evaluated cardiac histological lesions and NADPH genotype (polymorphisms rs1883112, rs4673, and rs13058338) in 97 consecutive decedents with a cancer diagnosis (48 treated with anthracyclines).

Results.
Myocytolysis (60%), patched myocardial necrosis (19%), and myocardial fibrosis (diffuse and patched; 62% and 23%, respectively) were associated with anthracycline treatment. In patients receiving anthracyclines, NADPH oxidase polymorphism rs4673 protected against focal myocardial necrosis (odds ratio [OR], 0.11; 95% confidence interval [CI], 0.20–0.63) whereas rs1883112 was strongly associated with cardiac fibrosis (OR, 5.11; 95% CI, 1.59–16.43), which was present in all homozygotes.

Conclusion.
Anthracyclines induce a cardiac remodeling pattern characterized by interstitial or patched fibrosis. The contribution of the functionally relevant NADPH polymorphisms rs1883112 and rs4673 to anthracycline-related heart lesions provides a plausible explanation for their modulation of cardiotoxicity. If confirmed, these findings may lead to better individualized strategies for early detection and prevention of anthracycline cardiotoxicity.
Toxicity of Bevacizumab in Combination with Chemotherapy in Older Patients
Authors: Mohile Supriya G. , Hardt Molly , Tew William , Owusu Cynthia , Klepin Heidi , Gross Cary , Gajra Ajeet , Lichtman Stuart M. , Feng Tao , Togawa Kayo , Ramani Rupal , Katheria Vani , Hansen Kurt , Hurria Arti ,   Cancer and Aging Research Group.
Published: April 2013

Abstract

Learning Objectives
Compare characteristics of older patients that receive bevacizumab plus chemotherapy to those treated with chemotherapy alone for advanced NSCLC and CRC. Compare outcomes between older patients treated with bevacizumab plus chemotherapy to chemotherapy alone for advanced NSCLC and CRC. Describe toxicities in older patients treated with bevacizumab plus chemotherapy for advanced NSCLC and CRC.

Background.
Bevacizumab leads to improved survival for patients with metastatic colorectal cancer (CRC) or non-small cell lung cancer (NSCLC) when added to chemotherapy. Little is known about factors associated with receipt of bevacizumab, or whether bevacizamab is associated with increased toxicity when added to chemotherapy.

Patients and Methods.
We conducted a prospective study of patients aged ≥65 years, which evaluated the association between geriatric assessment (GA) metrics and chemotherapy toxicity. We examined differences in characteristics and outcomes of patients with CRC and NSCLC cancers who received bevacizumab with chemotherapy versus chemotherapy alone.

Results.
From a total of 207 patients, 27 (13%) received bevacizumab plus chemotherapy and 180 (87%) received chemotherapy alone. Groups were similar in sociodemographic and cancer characteristics. There were no baseline differences in GA domains except that patients with heart disease were less likely to receive bevacizumab (4% vs. 26%, p = .01). Seventy-eight percent of patients who had bevacizumab had grade 3–5 toxicity compared to only 57% who received chemotherapy alone (p = .06). Patients receiving bevacizumab were more likely to develop grade 3 hypertension than those who received chemotherapy alone (15% vs. 2%, p &lt; .01). In multivariable analysis, factors associated with grade 3 or more toxicity included: bevacizumab (OR: 2.86, p = .04), CRC (OR: 2.54, p &lt; .01), and baseline anemia (OR: 2.58, p = .03).

Conclusion.
Heart disease was more common in those who did not receive bevacizumab. Older patients who receive bevacizumab with chemotherapy have a higher odds of developing a grade 3–5 toxicity compared with those who receive chemotherapy alone.
Antiangiogenic Therapies for Advanced Hepatocellular Carcinoma
Authors: Sampat Keeran R. , O'Neil Bert 
Published: April 2013

AbstractHepatocellular carcinoma (HCC) is a significant cause of death worldwide. HCC is a highly vascular tumor, and proangiogenic cytokines such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), and fibroblast growth factor may play crucial roles in this disease. Sorafenib, a multikinase inhibitor that blocks VEGF and PDGF signaling, was the first systemic therapy to demonstrate improved survival in patients with advanced HCC. Several other drugs targeting VEGF are in development. Because of the anticipation of eventual resistance to anti-VEGF therapies, drugs that also target alternative proangiogenic pathways are being investigated. Recent clinical and preclinical data along with ongoing studies are reviewed.
Approval Summary: Cetuximab in Combination With Cisplatin or Carboplatin and 5-Fluorouracil for the First-Line Treatment of Patients With Recurrent Locoregional or Metastatic Squamous Cell Head and Neck Cancer
Authors: Cohen Martin H. , Chen Huanyu , Shord Stacy , Fuchs Chana , He Kun , Zhao Hong , Sickafuse Sharon , Keegan Patricia , Pazdur Richard 
Published: April 2013

Abstract

Learning Objectives
Compare survival outcomes among patients with SCCHN treated with a platinum/5 -FU regimen with and without cetuximab. Compare adverse event profiles among patients with SCCHN treated with a platinum/5 -FU regimen with and without cetuximab. Describe potential risk-benefit issues identified in the EU and US studies.
On November 7, 2011, the U.S. Food and Drug Administration approved cetuximab in combination with cisplatin or carboplatin and 5-fluorouracil for the first-line treatment of patients with recurrent locoregional or metastatic squamous cell head and neck cancer. Approval was based on a randomized study of 442 patients conducted outside the U.S. Cisplatin (100 mg/m2 intravenously) or carboplatin (area under the curve 5 intravenously) on day 1 with 5-fluorouracil (1,000 mg/m2/day continuous intravenous infusion days 1–4) were administered every 3 weeks. Cetuximab, 400 mg/m2 intravenously, was administered initially followed by cetuximab, 250 mg/m2 intravenously weekly. After completion of six planned treatment courses, cetuximab patients without progression continued cetuximab 250 mg/m2 weekly. The study used European Union (EU)-approved cetuximab rather than U.S.-approved cetuximab. U.S.-approved cetuximab provides approximately 28% higher exposure relative to EU-approved cetuximab in a pharmacokinetic comparability study in monkeys. Overall survival, the primary efficacy endpoint, was significantly improved in cetuximab-treated patients (hazard ratio [HR]: 0.80; 95% confidence interval [CI]: 0.64–0.98; p = .034, stratified log-rank test). Median survival times were 10.1 and 7.4 months, respectively. Progression-free survival (PFS) was also significantly improved in patients receiving cetuximab (HR: 0.57; 95% CI: 0.46–0.72; p &lt; .0001). Median PFS times were 5.5 and 3.3 months, respectively. Response rates were 35.6% and 19.5% (odds ratio: 2.33; 95% CI: 1.50–3.60; p = .0001). Adverse reactions (≥25%) from cetuximab plus chemotherapy treatment included nausea, anemia, vomiting, neutropenia, rash, asthenia, diarrhea, and anorexia. Conjunctivitis occurred in 10% of cetuximab patients. Other adverse reactions, sometimes severe, included infusion reactions, hypomagnesemia, hypocalcemia, and hypokalemia.
Species density obtained for fish sampled with three seine nets hauled individually towards a stop net or a bank
Authors: Penczak Tadeusz 
Published: April 2013

Abstract
Researchers continuously search for adequate and inexpensive fish sampling methods and, as such, it is worth remembering the quantitative seine method with three identical nets hauled individually towards a stop net or a bank. A sample obtained by three nets is the absolute minimum for any accurate estimate employing a removal technique, and this procedure provides an estimate of density with a known error, because it allows for calculations of the variance value. Density (the number of individuals calculated from the model, as per defined area or volume), a popular term in the previous century when a secondary production and bioenergetics budget studies were considered to be modern investigations, but now when it is used with different meanings, an attempt has to be undertaken to sort out this terminology.
Early Experiences with Management of Extra Hepatic Portal Vein Obstruction
Authors: Rawal Sushil Bahadur , Malla Srijan , Giri Naresh Kumar , Rayamajhi Jyoti , Shah Kunda 
Published: April 2013

Introduction: Extrahepatic portal vein obstruction (EHPVO), a rare condition, is increasingly being diagnosed due to easier availability of proper diagnostic tools and early referrals. Here we report our series of 16 cases of EHPVO who were treated at our hospital. The aim of this paper is to share our early experiences of managing this rare and difficult condition. Methods: A retrospective analysis of patients’ records admitted with the diagnosis of EHPVO for a period of 18 months from Jan 2008 to June 2010 was performed. Patients were followed up for at least 9 months, their demographic data and outcome of surgery was analysed. Results: Of the 10 cases fulfilling the inclusion criteria, 9 underwent surgical therapy. Distal lienorenal shunt was performed in 4 patients, proximal lienorenal shunt in 2 patients and devascularisation procedure in 3 patients. Rebleeding was seen in 2 patients. The prognosis of EHPVO was good in patients without a severe underlying disease at a median follow up of 9 months. Conclusion: Conventional surgical therapies have a good outcome in management of EHPVO in our context. Medical Journal of Shree Birendra Hospital; July-December 2012/vol.11/Issue2/4-6 DOI: http://dx.doi.org/10.3126/mjsbh.v11i2.7898
Treatment Outcome of Tennis Elbow by Percutaneous Needle Tenotomy
Authors: Kayatha Nirab , Joshi Amit , Chand Pankaj , Thapa Bishnu Babu , Rana Sushil , Singh Bharat Prasad , KC Bachhu Ram , Shah Bhanu Chandra 
Published: April 2013

Introduction: Tennis elbow (TE), or lateral epicondylitis of the humerus, is a painful condition seen commonly in the daily practice of Orthopaedic surgeons. One of the myriad of treatment methods for TE is percutaneous needle tenotomy of the common extensor origin. It is a simple operation with minimal morbidity and good-to-excellent results in most of the patients. The aim of this study was to evaluate the outcome in patients with chronic TE. Methods: this was a prospective study in 33 consecutive patients of both sexes with TE who were above 30 years of age. An 18 Gauge hypodermic needle was used under local anaesthesia to percutaneously tenotomise the extensor origin at the point of maximum tenderness. Visual analogue score (VAS) was used to assess the pain prior to intervention and in subsequent follow-ups at first, third, sixth and 12th weeks. Persistence of pain and return to activities of the patients was used to evaluate outcome as excellent, good, fair or poor. Results: At the end of 12 weeks, eleven out of 30 elbows (36.7%) had an excellent outcome, 13 (43.3%) had good, 5 (16.7%) had fair and 1 patient (3.3%) had poor outcome. At first week follow-up, the mean pain at rest was 4.60, the same at night was 2.73 and activity pain was a mean of 7.70 (max-9, min-5). By 12 week follow-up, the mean VAS scores at rest, night and activites were 0.87, 0.63 and 1.53 respectively, showing significant decrease in pain. Conclusions:Percutaneous tenotomy is a simple, safe, patient friendly, effective and easily reproducible method of treating tennis elbow.Medical Journal of Shree Birendra Hospital; July-December 2012/vol.11/Issue2/32-35 DOI: http://dx.doi.org/10.3126/mjsbh.v11i2.7907
Crystalline Penicillin for Community Acquired Pneumonia: Does it still work?
Authors: Aryal Nirjala , Neopane Arun Kumar , Thapa Moon , Singh Umesh Kumar , Agrawal Keshav 
Published: April 2013

Introduction: Pneumonia is the most common cause of mortality and morbidity in children in underdeveloped countries. The common bacterial agents are Streptococcus pneumonia followed by Haemophilus influenzae type b. The only measure to treat bacterial pneumonia is the correct use of antibiotics along with oxygen in moderate to severe cases. The objectives of this study were to see the clinical features of community-acquired pneumonia and to observe the response to treatment with crystalline penicillin in hospitalized children. Methods: This study was a prospective study. The children aged between two months to 59 months with pneumonia were treated with intravenous crystalline penicillin. Response was observed by normalization of respiratory rate and absence of lower chest indrawing. Results: Out of 88 children treated, 79(89.8%) showed improvement in 48 hours. In children who had tachypnoea, 62.9% showed normalization in respiratory rate in the first 24 hours and 37.1 percent in 48 hours of treatment. Similarly, among children with lower chest indrawing; 61.1% showed improvement in 24hours and the remaining in 48hours. In 24 hours of treatment 17.7% of children became afebrile and 46.8% in 48hours of treatment. Conclusion: The most common clinical features like cough, fever, tachypnoea and lower chest indrawing can be used to diagnose CAP where Chest X- ray is not possible. The response to treatment with Crystalline Penicillin is a very good and, thus, can be used as the first line drug in the treatment of children with CAP.Medical Journal of Shree Birendra Hospital; July-December 2012/vol.11/Issue2/36-39 DOI: http://dx.doi.org/10.3126/mjsbh.v11i2.7908
“The Gateway to the Last Great West”: Spatial Histories of the Athabasca Landing Trail
Authors: Dyce Matt 
Published: April 2013

Abstract: The Landing Trail was a Hudson's Bay Company supply route used between metropolitan Edmonton and frontier Athabasca during the late nineteenth century. This article begins with the rediscovery of the trail in 1950s Alberta and analyzes its diverse archival life in the two communities. In three sections, it moves through a fifty-year period of attempts to commemorate, represent, and archive the history of the trail as it existed in the 1890s. As groups in Edmonton and Athabasca sought to reinvest the trail with meaning, they also represented dynamics of power between the two places, each articulating a different version of Alberta's historical geography. I show that the commemorative and archival practices that unfolded between the 1950s and the present used history to reflect and interpret contemporary geographical relationships between Edmonton and Athabasca. I conclude that these stories of the trail and the archives they produced constitute spatial histories, because their meanings were informed by representational spaces in the present. A theory for using spatial history is elaborated throughout the paper.
Book Reviews
Authors: Dean Marie A. , Beavis Mary Ann , McBride James , Mazur Eric Michael , Dalton Lisle 
Published: April 2013

Jennifer E. Porter, and Darcee L. McLaren, ed., Star Trek and Sacred Ground, reviewed by Marie A. Dean Peter Emberley, Divine Hunger: Canadians on Spiritual Walkabout, reviewed by Mary Ann Beavis Tony Ladd and James A. Mathisen, Muscular Christianity: Evangelical Protestants and the Development of American Sports, reviewed by James McBride David Rosen, The Tao of Elvis, reviewed by Eric Michael Mazur Christopher H. Evans and William R. Herzog, The Faith of 50 Million: Baseball, Religion, and American Culture, reviewed by Lisle Dalton
Book Reviews
Authors: Auger Emily E. , Szcypa Piotr , Paradis Kenneth , Kelley Kate S. , Smith Andrew 
Published: April 2013

Christopher Partridge and Eric Christianson, eds. The Lure of the Dark Side: Satan & Western Demonology in Popular Culture, reviewed by Emily E. Auger John Lyden, ed. The Routledge Companion to Religion and Film, reviewed by Piotr Szczypa Jackson, Gregory. The Word and Its Witness: The Spiritualization of American Realism, reviewed by Kenneth Paradis Thompson, Kirsten Moana. Apocalyptic Dread: American Film at the Turn of the Century, reviewed by Kate S. Kelley Turner, Richard Brent. Jazz Religion, the Second Line, and Black New Orleans, reviewed by Andrew Smith
Building a Theatrical Vernacular: Responsibility, Community, Ambivalence, and Queer Theatre
Authors: Dolan Jill 
Published: April 2013

I originally presented the bulk of this article as the keynote at the Queer Theatre Conference presented in New York City last spring. "Queer Theatre, A Conference With Performances" was held April 27-29, 1995. The conference was presented by the Center for Lesbian and Gay Studies (CLAGS) at the Graduate Center of the City University of New York and co-sponsored by the CUNY Graduate Center's Theatre Program; it was co-hosted by the Arts Program at the Judson Memorial Church, New York Theatre Workshop, La Mama E.T.C., and .the Joseph Papp Public Theatre. Because of the visibility and heft of CLAGS and its hosts, the conference was advertised nationally and attended by scholars, practitioners, critics, and spectators from around the United States. Because of the historical importance of the Queer Theatre conference, I've decided that I want to mark the occasion of that event here by preserving the keynote much as it was delivered. Often, when academics publish work that began as a lecture or a paper, our effort is to mask the original constituency for which it was written. Rather than subsuming this piece in a rethought set of propositions, geared to a more readerly audience, I want to evoke the moment into which these words were spoken.