bluuebunny/crossref_metadata_2025_split huggingface dataset:
Schallschutz mit Glas
Authors: Elstner Michael , Broich Markus , Goldau Denise , Schäfer Steffen 
Published: April 2013

AbstractMit zunehmender Lärmbelastung von Anwohnern in Innenstädten nimmt der Wunsch nach ausreichendem Schallschutz zu. Die Reduzierung der Lärmbelästigung ist schon bei der Planung zu beachten. Somit kommt dem baulichen Schallschutz eine besondere Bedeutung zu. Der Baustoff Glas erfreut sich zunehmender Beliebtheit, was sich an größer werdenden Glasflächen in der Gebäudehülle darstellt. Es gibt mittlerweile viele Anforderungen an Fassade, Fenster und Glas in Gebäudehülle und Innenausbau. Neben der Wärmedämmung sollte ein ausreichender Schallschutz erfüllt werden. Dieser Aufsatz zeigt, auf Basis eines aktuellen Merkblatts des Bundesverbandes Flachglas “Schallschutz mit Glas“, Grundlagen und Möglichkeiten der Schalldämmung mit Glas, um in der Planungs‐ und Ausführungsphase die richtigen Hinweise zu geben, wie der Schallschutz mit Glas verbessert wird und welche Einflüsse Schallschutzmaßnahmen haben.Acoustic Insulation with Glass. As a result of increasing noise pollution in inner‐city areas affecting residents the demand also increases for adequate acoustic insulation. The reduction of noise pollution must be taken into account already at concept stage. As a result structural components are of special importance. Glass is more and more favoured as a building material, a development which finds visible expression in larger proportions of transparent envelopes. Nowadays many requirements exist not only on facades and windows but also as an element for interior design. In addition to thermal insulation adequate acoustic insulation shall also be provided. The present paper points out, based on the Fact Sheet “Acoustic Insulation With Glass” issued by the Bundesverband Flachglas, both the foundations and possibilities of sound insulation with glass, in order to provide the right hints already at the concept and design stage and during execution. This includes how sound insulation with glass can be improved and the influence of the different measurements on it.
Primärenergieeinsparung durch edelgasgefüllte Isolierverglasungen
Authors: Reich Stefan , Weller Bernhard , Fahrion Marc‐Steffen 
Published: April 2013

AbstractDurch den Einsatz von modernen Mehrscheiben‐Isolierverglasungen lässt sich der Primärenergiebedarf von Gebäuden senken. Die volkswirtschaftlichen Auswirkungen unterschiedlicher Verglasungen werden anhand eines typischen Einfamilienhauses dargelegt und auf volkswirtschaftliche Größen extrapoliert. Besondere Beachtung erfordert die Sicherstellung einer dauerhaften Edelgasfüllung, die stark von der Fertigungsqualität des Randverbundes, der aus einer Vielzahl von Komponenten und Materialien hergestellt wird, abhängt.Energy saving by means of gas filled insulating glazing. The use of modern insulating glazing enables a reduction of the energy consumption of buildings. The general economic effect of different glazing types on the German economy is derived by means of energy consumption calculations of a single house. Especially the production quality of the edge sealing with its numerous components and materials influences the long term insulation effect of the gas filling.
Tragverhalten von nicht‐monolithischen Glasverbundträgern für große Spannweiten
Authors: Trösch Erich , Baumgärtner Thomas 
Published: April 2013

AbstractIn der modernen Architektur wird Glas verstärkt als Konstruktionsmaterial eingesetzt. So werden Glasschwerter, Dachträger, Fassadenstützen und sogar ganze Glasbrücken aus Verbundsicherheitsglas hergestellt. In der Vergangenheit war man jedoch von den realisierbaren Dimensionen sehr eingeschränkt. Glas Trösch hat die Herausforderung angenommen und hat erstmals auf der glasstec 2010 in Düsseldorf einen 21 m langen Verbundglasträger präsentiert. (Bild 1‐1 und 1‐2) Diese Weltneuheit traf bei Architekten und Bauherrn auf sehr großes Interesse. Dies hat das Unternehmen Glas Trösch dazu bewegt, das Tragverhalten von derartig großen Trägern wissenschaftlich zu untersuchen.Load‐bearing behaviour of non‐monolithic glass laminate beams for wide spans. In modern architecture, glass is increasingly being used as a structural material. For example, glass fins, roof beams, facade supports and even entire glass bridges are being made from laminated safety glass. In the past, however, this was much restricted by the achievable dimensions. Glas Trösch took up the challenge, presenting for the first time a 21 meter long laminated glass beam at the glasstec 2010 in Düsseldorf. (Figures 1‐1 and 1‐2) This world‐first met with considerable interest from architects and builders. That prompted the company to conduct a scientific investigation on the load‐bearing behaviour of large beams of this type.
Unresectable Colorectal Liver Metastases: The Safety and Efficacy of Conversion Therapy Using Hepatic Arterial Infusion Immunochemotherapy with 5‐Fluorouracil and Polyethylene Glycol‐Interferon α‐2a
Authors: Nakai Takuya , Okuno Kiyotaka , Kitaguchi Hiroshi , Ishikawa Hajime , Yamasaki Mitsuo 
Published: April 2013

AbstractBackgroundHepatic arterial infusion (HAI) or systemic chemotherapy has been used to treat unresectable colorectal liver metastases. The prognosis of the disease in recent years has been improved because chemotherapy is performed before hepatectomy to reduce tumor size (conversion therapy). The purpose of this study was to investigate the safety and efficacy of conversion therapy following HAI immunochemotherapy.MethodsHepatic arterial infusion of 5‐fluorouracil (5‐FU)/polyethylene glycol (PEG)‐IFNα‐2a was performed in 21 patients. The primary endpoint was the safety of HAI and hepatectomy. The secondary endpoints were response rate, rate of conversion to hepatectomy, survival rate, and prognostic factors.ResultsWith regard to side effects, drugs were discontinued temporarily in one patient because of a decrease in white blood cell count; however, other patients continued chemotherapy. The response rate with HAI was 61.9 %, and the conversion rate was 38.1 %. Hepatectomy was completed successfully without mortality. Median progression‐free survival (PFS) was 11.5 months (with and without conversion, 16.7 and 4.8 months, respectively; p = 0.021). Median overall survival was 34.6 months (with and without conversion, 48.4 and 26.6 months, respectively; p = 0.003). Prognosis was poor when the number of metastatic tumors was ≥10 [PFS: hazard ratio (HR) 32.21, p = 0.003; overall survival (OS): HR 9.13, p = 0.07], but prognosis improved after hepatectomy (OS: HR 0.08, p = 0.09).ConclusionsHepatic arterial infusion immunochemotherapy with 5‐FU/PEG‐IFNα‐2a was performed safely without major side effects. Prognosis is expected to improve after successful conversion to hepatectomy.
It Takes a Village: The Effects of 10th Grade College‐Going Expectations of Students, Parents, and Teachers Four Years Later
Authors: Gregory Anne , Huang Francis 
Published: April 2013

AbstractAdolescents are surrounded by people who have expectations about their college‐going potential. Yet, few studies have examined the link between these multiple sources of college‐going expectations and the actual status of students in postsecondary education years later. The study draws on data collected in the 2002–2006 Educational Longitudinal Study and employs an underutilized statistical technique (cross‐classified multilevel modeling) to account for teacher reports on overlapping groups of students (typical of high school research). Results showed that positive expectations of students, parents, English, and mathematics teachers in the 10th grade each uniquely predicted postsecondary status 4 years later. As a group, the four sources of expectations explained greater variance in postsecondary education than student characteristics such as socioeconomic status and academic performance. This suggests positive expectations are additive and promotive for students regardless of their risk status. Teacher expectations were also found to be protective for low income students. Implications for future expectancy research and equity‐focused interventions are discussed.
Carnitine supplementation attenuates myocardial lipid accumulation in long‐chain acyl‐CoA dehydrogenase knockout mice
Authors: Bakermans Adrianus J. , van Weeghel Michel , Denis Simone , Nicolay Klaas , Prompers Jeanine J. , Houten Sander M. 
Published: April 2013

AbstractPurposeElevation of long‐chain acylcarnitine levels is a hallmark of long‐chain mitochondrial β‐oxidation (FAO) disorders, and can be accompanied by secondary carnitine deficiency. To restore free carnitine levels, and to increase myocardial export of long‐chain fatty acyl‐CoA esters, supplementation of L‐carnitine in patients has been proposed. However, carnitine supplementation is controversial, because it may enhance the potentially lipotoxic buildup of long‐chain acylcarnitines in the FAO‐deficient heart. In this longitudinal study, we investigated the effects of carnitine supplementation in an animal model of long‐chain FAO deficiency, the long‐chain acyl‐CoA dehydrogenase (LCAD) knockout (KO) mouse.MethodsCardiac size and function, and triglyceride (TG) levels were quantified using proton magnetic resonance imaging (MRI) and spectroscopy (1H‐MRS) in LCAD KO and wild‐type (WT) mice. Carnitine was supplemented orally for 4 weeks starting at 5 weeks of age. Non‐supplemented animals served as controls. In vivo data were complemented with ex vivo biochemical assays.ResultsLCAD KO mice displayed cardiac hypertrophy and elevated levels of myocardial TG compared to WT mice. Carnitine supplementation lowered myocardial TG, normalizing myocardial TG levels in LCAD KO mice. Furthermore, carnitine supplementation did not affect cardiac performance and hypertrophy, or induce an accumulation of potentially toxic long‐chain acylcarnitines in the LCAD KO heart.ConclusionThis study lends support to the proposed beneficial effect of carnitine supplementation alleviating toxicity by exporting acylcarnitines out of the FAO‐deficient myocardium, rather than to the concern about a potentially detrimental effect of supplementation‐induced production of lipotoxic long‐chain acylcarnitines.
The Ancient Dancer in the Modern World: Responses to Greek and Roman Dance edited by Fiona Macintosh; Modernism's Mythic Pose: Gender, Genre, Solo Performance by Carrie J. Preston
Authors: Bassi Karen 
Published: April 2013

Perhaps the best-known dancer from Greek antiquity is Hippocleides, who was a suitor for the hand of the daughter of Cleisthenes, the tyrant of Sicyon in the sixth century BCE. According to Herodotus, Hippocleides was “the most outstanding man in Athens for his wealth and good looks,” and Cleisthenes preferred him for his son-in-law “because of his courage” (or “manly virtue,” andragathiê) and because he was related to the Cypselidae of Corinth (Histories 6.127–8). On the day Cleisthenes was to make his decision, however, things took a wrong turn (Histories 6.129.2–4; trans. Waterfield 1998):
After the meal, the suitors competed with one another at singing and at public speaking. As the drinking progressed, Hippocleides had a clear lead over the others, but then he told the pipe-player to strike up a tune, and when the musician did so he began to dance (orchêsato). Now, although Hippocleides liked his own dancing a lot, Cleisthenes was beginning to look on the whole business askance. After a while, Hippocleides stopped momentarily and asked for a table to be brought in. When the table arrived there, he first danced a Laconian dance on it, then some Attic figures, and finally stood on his head on the table and waggled his feet around. Hippocleides' uninhibited dancing of the first and second sets of figures had already put Cleisthenes off having him as a son-in-law, but he kept silent because he did not want to scold him. When he saw him making hand gestures with his legs (echeironomêse), however, he could no longer restrain himself. “Son of Tisander,” he said, “you have danced away (aporchêsao) your marriage.” The young man replied, “Hippocleides doesn't care! And that is how the proverb arose.
Health impacts of eicosapentaenoic acid and docosahexaenoic acid.
Authors: Mateos H. T. , Lewandowski P. A. , Vaughan V. C. , Su X. Q. 
Published: April 2013

Abstract

Long chain omega-3 polyunsaturated fatty acids (LC
n
-3 PUFA) particularly, eicosapentaenoic acid (EPA, 22: 5
n
-3) and docosahexaenoic acid (DHA, 22: 6
n
-3) have been reported to reduce the risks of cardiovascular disease (CVD) including myocardial infarction, stroke, coronary artery disease and sudden cardiac death. In addition, these fatty acids play an important role in reduction of cancer risks, Alzheimer's disease, depression and schizophrenia. Furthermore, studies also showed that EPA and DHA are important for foetal development, particularly neuronal and retinal functions. Several recent human trials have strengthened the evidence that EPA and DHA can reduce the risks of various chronic diseases although this has not been a uniform finding. In general, the high prevalence of mortality caused by chronic disease can be prevented by consumption of LC
n
-3 PUFA, which has been proven to have considerable health benefits. The aim of this paper was to review main scientific evidence regarding the health impact of LC
n
-3 PUFA, especially EPA and DHA on chronic disease including CVD, cancer, mental health, arthritis and infant development.
Structural and nanomechanical properties of InN films grown on Si(1 0 0) by femtosecond pulsed laser deposition
Authors: Hafez M A , Mamun M A , Elmustafa A A , Elsayed-Ali H E 
Published: April 2013

Abstract
The structural and nanomechanical properties of InN films grown on Si(1 0 0) using femtosecond pulsed laser deposition were studied for different growth conditions. Atomic nitrogen was generated by either thermal cracking or laser-induced breakdown (LIB) of ammonia. Optical emission spectroscopy was conducted on the laser plasma and used to observe atomic nitrogen formation. An indium buffer layer was initially grown on the Si substrate at low temperature. The surface structure and morphology were investigated by in situ reflection high-energy electron diffraction, ex situ atomic force microscopy and x-ray diffraction (XRD). The results show that the initial buffer indium layers were terminated with the In(2 × 1) structure and had a smooth surface. With increased coverage, the growth mode developed from two-dimensional layers to three-dimensional islands. At room temperature (RT), formation of submicrometre islands resulted in mixed crystal structure of In and InN. As the substrate temperature was increased to 250–350 °C, the crystal structure was found to be dominated by fewer In and more InN, with only InN formed at 350 °C. The XRD patterns show that the grown InN films have wurtzite crystal structure. The film hardness near the surface was observed to increase from less than 1 GPa, characteristic of In for the sample grown at RT using the thermal cracker, to a hardness of 11 GPa at 30 nm from surface, characteristic of InN for samples grown at 350 °C by LIB. The hardness at deep indents reaches the hardness of the Si substrate of ∼12 GPa.
Detecting regulatory gene–environment interactions with unmeasured environmental factors
Authors: Fusi Nicoló , Lippert Christoph , Borgwardt Karsten , Lawrence Neil D. , Stegle Oliver 
Published: April 2013

Abstract
Motivation: Genomic studies have revealed a substantial heritable component of the transcriptional state of the cell. To fully understand the genetic regulation of gene expression variability, it is important to study the effect of genotype in the context of external factors such as alternative environmental conditions. In model systems, explicit environmental perturbations have been considered for this purpose, allowing to directly test for environment-specific genetic effects. However, such experiments are limited to species that can be profiled in controlled environments, hampering their use in important systems such as human. Moreover, even in seemingly tightly regulated experimental conditions, subtle environmental perturbations cannot be ruled out, and hence unknown environmental influences are frequent. Here, we propose a model-based approach to simultaneously infer unmeasured environmental factors from gene expression profiles and use them in genetic analyses, identifying environment-specific associations between polymorphic loci and individual gene expression traits.
Results: In extensive simulation studies, we show that our method is able to accurately reconstruct environmental factors and their interactions with genotype in a variety of settings. We further illustrate the use of our model in a real-world dataset in which one environmental factor has been explicitly experimentally controlled. Our method is able to accurately reconstruct the true underlying environmental factor even if it is not given as an input, allowing to detect genuine genotype–environment interactions. In addition to the known environmental factor, we find unmeasured factors involved in novel genotype–environment interactions. Our results suggest that interactions with both known and unknown environmental factors significantly contribute to gene expression variability.
Availability: and implementation: Software available at http://pmbio.github.io/envGPLVM/.
Contact: oliver.stegle@ebi.ac.uk or nicolo.fusi@sheffield.ac.uk
Supplementary information: Supplementary data are available at Bioinformatics online.
Bayesian hierarchical model of protein-binding microarrayk-mer data reduces noise and identifies transcription factor subclasses and preferredk-mers
Authors: Jiang Bo , Liu Jun S. , Bulyk Martha L. 
Published: April 2013

AbstractMotivation: Sequence-specific transcription factors (TFs) regulate the expression of their target genes through interactions with specific DNA-binding sites in the genome. Data on TF-DNA binding specificities are essential for understanding how regulatory specificity is achieved.Results: Numerous studies have used universal protein-binding microarray (PBM) technology to determine the in vitro binding specificities of hundreds of TFs for all possible 8 bp sequences (8mers). We have developed a Bayesian analysis of variance (ANOVA) model that decomposes these 8mer data into background noise, TF familywise effects and effects due to the particular TF. Adjusting for background noise improves PBM data quality and concordance with in vivo TF binding data. Moreover, our model provides simultaneous identification of TF subclasses and their shared sequence preferences, and also of 8mers bound preferentially by individual members of TF subclasses. Such results may aid in deciphering cis-regulatory codes and determinants of protein–DNA binding specificity.Availability and implementation: Source code, compiled code and R and Python scripts are available from http://thebrain.bwh.harvard.edu/hierarchicalANOVA.Contact: bojiang83@gmail.com or mlbulyk@receptor.med.harvard.eduSupplementary information: Supplementary data are available at Bioinformatics online.
Late gadolinium enhancement cardiac magnetic resonance imaging for the prediction of ventricular tachyarrhythmic events: a meta‐analysis
Authors: Scott Paul A. , Rosengarten James A. , Curzen Nick P. , Morgan John M. 
Published: April 2013

AimsApproaches to the risk stratification for sudden cardiac death (SCD) remain unsatisfactory. Although late gadolinium enhancement cardiac magnetic resonance imaging (LGE‐CMR) for SCD risk stratification has been evaluated in several studies, small sample size has limited their clinical validity. We performed this meta‐analysis to better gauge the predictive accuracy of LGE‐CMR for SCD risk stratification.Methods and resultsElectronic databases and published bibliographies were systematically searched to identify studies evaluating the association between the extent of LV scar on LGE‐CMR and ventricular arrhythmic events [SCD, resuscitated cardiac arrest, the occurrence of ventricular arrhythmias, or appropriate implantable cardioverter defibrillator (ICD) therapy]. Only studies enrolling patients with CAD or non‐ischaemic cardiomyopathy were included. Summary estimates of the relative risk (RR) and likelihood ratios (LRs) were calculated using random effects models. Eleven studies comprising 1105 patients were identified. During a mean/median follow‐up of 8.5–41 months 207 patients had ventricular arrhythmic events. Ventricular arrhythmic events were more common in patients with a greater extent of LV scar: RR 4.33 [95% confidence interval (CI) 2.98–6.29], positive LR 1.98 (95% CI 1.66–2.37), and negative LR 0.33 (95% CI 0.24–0.46).ConclusionThe extent of LGE on CMR is strongly associated with the occurrence of ventricular arrhythmias in patients with reduced LVEF and may be a valuable risk stratification tool for identifying patients who will benefit from ICD therapy. However, uncertainties regarding clinical application persist and need to be addressed prior to introduction into broad clinical practice.
First Report of Soybean vein necrosis-associated virus in Ohio Soybean Fields
Authors: Han J. , Domier L. L. , Dorrance A. E. , Qu F. 
Published: April 2013

Soybean vein necrosis-associated virus (SVNaV), a newly discovered tospovirus that infects soybean, was first described as widespread in a number of southern and midwestern states, but so far has not been reported in Ohio (1). Here we describe its occurrence in six different soybean leaf samples collected from five Ohio counties: Champaign, Hardin, Sandusky, Seneca, and Wyandot. Specifically, SVNaV was initially identified through a comprehensive survey during the summer of 2011 that used high throughput sequencing to detect genome sequences of viruses present in a pool of 110 field samples collected from 24 Ohio counties. Three assembled contigs, with sizes of 7,551, 4,937, and 1,554 nucleotides (nt) respectively, share 99% nt identity with the three SVNaV genomic RNAs (L, M, and S), and thus constitute partial sequences of the SVNaV Ohio (OH) isolate. The distribution of this virus was further delineated using reverse transcription (RT)-PCR with primers SVNaV-1734F (5′ CCATCTTTCTTTCCAGGCATTTCA 3′) and SVNaV-S-2421R (5′ GATTCAAGTTCAGCGAGTTCTACAA 3′). All plants from which the SVNaV-positive samples were collected showed typical virus symptoms, including systemic mosaic accompanied by leaf deformation, chlorosis, vein necrosis, and rusty spots on mature leaves. These symptoms are largely consistent with the previous report by Zhou and colleagues (1). Intriguingly, further analysis with RT-PCR revealed that five out of the six SVNaV-positive samples also contained a second virus, with Bean pod mottle virus found in four of the samples, and Tobacco ringspot virus in the fifth. Since it is not yet possible to initiate SVNaV infection mechanically, it is difficult to determine whether the co-infecting viruses contribute to the disease symptoms and yield losses. It should be noted that SVNaV may have been in Ohio for some time since symptoms similar to those reported by Zhou and colleagues (1) have been observed in soybean fields of this state since at least 2009. Furthermore, while in 2011 these symptoms were observed in only a few fields, as reflected by the detection of SVNaV in six of the 110 samples, the 2012 growing season has seen a big jump of symptomatic plants and fields. The current report confirms its presence with molecular evidence and lays the groundwork for further assessment of its impact on soybean production. Reference: (1) J. Zhou et al. Virus Genes 43:289, 2011.