bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful Nonsurgical Treatment of Esophagopericardial Fistulas After Atrial Fibrillation Catheter Ablation
Authors: Eitel Charlotte , Rolf Sascha , Zachäus Markus , John Silke , Sommer Philipp , Bollmann Andreas , Arya Arash , Piorkowski Christopher , Hindricks Gerhard , Halm Ulrich 
Published: June 2013

Background—
Esophageal perforations are a rare but devastating complication of atrial fibrillation catheter ablation. Rapid treatment is crucial to avoid permanent disabilities and death. Surgical treatment is considered the treatment of choice. Alternatively, single case reports describe successful esophageal stenting, but others discourage this approach because of fatal consequences.

Methods and Results—
We present 3 patients who developed esophagopericardial fistulas after radiofrequency catheter ablation of atrial fibrillation. Diagnosis and management with pericardial drainage and esophageal stenting, as well as long-term follow-up are described. Esophagopericardial fistulas occurred 26, 9, and 18 days after the ablation procedure. Symptoms leading to admission were recurrence of atrial fibrillation (n=1), elective control endoscopy for thermal lesion (n=1), and pain with swallowing (n=1). Computed tomography revealed esophagopericardial fistulas with pericardial effusion in all patients, while contrast leakage and air in the left atrium could be excluded. Broad-spectrum antibiotics were initialized, and minimally invasive pericardial drainage and esophageal stenting were performed. Stent dislocation occurred in 2 patients and was resolved by repositioning and clipping of the proximal stent end. After 45, 22, and 28 days, respectively, fistulas appeared closed and stents were removed. During follow-up, no embolic or septic events occurred. However, 2 patients underwent dilation of symptomatic esophageal stenosis in the formerly stented region.

Conclusions—
An early minimally invasive approach consisting of pericardial drainage and esophageal stenting proved effective in treating patients with esophagopericardial fistulas. However, constant interdisciplinary communication and attention is needed to recognize and manage potential evolving complications promptly.
Plasma Vitamin C, but Not Vitamin E, Is Associated With Reduced Risk of Heart Failure in Older Men
Authors: Wannamethee Sasiwarang Goya , Bruckdorfer Karl Richard , Shaper Andrew Gerald , Papacosta Olia , Lennon Lucy , Whincup Peter H. 
Published: June 2013

Background—
Oxidative stress has been implicated in the pathogenesis of heart failure (HF). However, data on the association between antioxidant intakes and circulating levels and risk of incident HF in the older general population are limited. We have examined prospectively the associations between plasma vitamin C and E, dietary intakes of vitamin C and E, and incident HF.

Methods and Results—
Prospective study of 3919 men aged 60 to 79 years with no prevalent HF followed up for a mean period of 11 years, in whom there were 263 cases with incident HF. Higher plasma vitamin C level was associated with significantly lower risk of incident HF in both men with and without previous myocardial infarction after adjustment for lifestyle characteristics, diabetes mellitus, blood lipids, blood pressure, and heart rate (hazards ratio [95% confidence interval], 0.81 [0.70, 0.93] and 0.75 [0.59, 0.97] for 1 SD increase in log vitamin C, respectively). Plasma vitamin E and dietary vitamin C intake showed no association with HF. High levels of dietary vitamin E intake (which correlated weakly with plasma vitamin E) were associated with increased risk of HF in men with no previous myocardial infarction even after adjustment (adjusted hazards ratio [95% confidence interval], 1.23 [1.06, 1.42] for 1 SD increase).

Conclusions—
Higher plasma vitamin C is associated with a reduced risk of HF in older men with and without myocardial infarction. High intake of dietary vitamin E may be associated with increased HF risk. Primary intervention trials assessing the effect of vitamin C supplements on HF risk in the elderly are needed.
Selective Inactivation of PTEN in Smooth Muscle Cells Synergizes With Hypoxia to Induce Severe Pulmonary Hypertension
Authors: Horita Henrick , Furgeson Seth B. , Ostriker Allison , Olszewski Kyle A. , Sullivan Timothy , Villegas Leah R. , Levine Michelle , Parr Jane E. , Cool Carlyne D. , Nemenoff Raphael A. , Weiser‐Evans Mary C. M. 
Published: June 2013

Background

Pulmonary vascular remodeling in pulmonary hypertension (
PH
) is characterized by increased vascular smooth muscle cell (
SMC
) and adventitial fibroblast proliferation, small vessel occlusion, and inflammatory cell accumulation. The underlying molecular mechanisms driving progression remain poorly defined. We have focused on loss of the phosphatase
PTEN
in
SMC
s as a major driver of pathological vascular remodeling. Our goal was to define the role of
PTEN
in human
PH
and in hypoxia‐induced
PH
using a mouse model with inducible deletion of

PTEN

in
SMC
s.

Methods and Results

Staining of human biopsies demonstrated enhanced inactive
PTEN
selectively in the media from hypertensive patients compared to controls. Mice with induced deletion of

PTEN

in
SMC
s were exposed to normoxia or hypoxia for up to 4 weeks. Under normoxia,
SMC

PTEN

depletion was sufficient to induce features of
PH
similar to those observed in wild‐type mice exposed to chronic hypoxia. Under hypoxia,

PTEN

depletion promoted an irreversible progression of
PH
characterized by increased pressure, extensive pulmonary vascular remodeling, formation of complex vascular lesions, and increased macrophage accumulation associated with synergistic increases in proinflammatory cytokines and proliferation of both
SMC
s and non
SMC
s.

Conclusions

Chronic inactivation of

PTEN

selectively in
SMC
represents a critical mediator of
PH
progression, leading to cell autonomous events and increased production of factors correlated to proliferation and recruitment of adventitial and inflammatory cells, resulting in irreversible progression of the disease.
Semantics and OntologyAn Assessment of Medieval Terminism
Authors: de Rijk † L.M. 
Published: June 2013

Abstract
This paper aims to assess medieval terminism, particularly supposition theory, in the development of Aristotelian thought in the Latin West. The focus is on what the present author considers the gist of Aristotle’s strategy of argument, to wit conceptual focalization and categorization. This argumentative strategy is more interesting as it can be compared to the modern tool known as ‘scope distinction’.
Avicenna’s Theory of Supposition
Authors: Bäck Allan 
Published: June 2013

Abstract
Although he does not have an explicit theory of supposition as is found in the works of Latin medieval philosophers, Avicenna (Ibn Sīnā) has two doctrines giving something equivalent: the threefold distinction of quiddity (triplex status naturae), corresponding to a division of simple, personal and material supposition, and his analyses of truth conditions for categorical propositions, where sentential context determines in part the reference of their terms. While he does address which individuals are being referred to by the universal terms used there, Avicenna concentrates more on the varied temporal durations of the predications being made. In Western terms, he has incorporated ampliation and restriction into the theory of supposition itself.
Supposition and the Fallacy of Figure of Speech in the Abstractiones
Authors: Sirridge Mary 
Published: June 2013

Abstract
I undertake to examine the practice of Richard, Master of Abstractions, with respect to supposition in his dealing with the fallacy of figure of speech. His practice turns out to support the ‘single theory’ account of the theory of personal supposition, as does his treatment of a functional equivalent of simple supposition, but his practice of proposing additional solutions points to changing attitudes with respect to species as separate entities. Questions having to do with material supposition and the like are completely absent, even in discussions where we might expect to find them.
Semantic and Ontological Aspects of Wyclif’s Theory of Supposition
Authors: Conti Alessandro D. 
Published: June 2013

Abstract
The relationship between thought and reality was a focal point of Wyclif’s reflection. On the one hand, Wyclif believed that thought was linguistically constrained by its own nature; on the other hand, he considered thought to be related to reality in its elements and constitution. Hence he deemed language, thought, and external reality to be of the same logical coherence. Within this context, the theory of supposition was intended to explain the different roles that terms can have in relation to language and the extra-mental world when they appear as extremes in propositions. Characteristically, his theory of supposition provides an account not only of the truth-values of a sentence, but also of its meaning; it is not therefore simply a theory of reference, but a sort of complex analysis of language viewed as a semiotic system whose unique interpretative model was reality itself. It gives clear evidence of Wyclif’s realist stance and of his conviction that any kind of linguistic and semantic features must be grounded on ontological structures.
Ockham and Buridan on Simple Supposition
Authors: Panaccio Claude 
Published: June 2013

Abstract
What is at stake, philosophically, in the disagreement between Ockham and Buridan is whether there is simple (or material) supposition in the mental language or not. The key difference is that Ockham’s theory allows for the possibility of use/mention ambiguities within mental language, while Buridan’s approach, whatever it is exactly, does not.
The Expressive Power of Medieval Logic
Authors: Parsons Terry 
Published: June 2013

Abstract
This paper is about the development of logic in the Aristotelian tradition, from Aristotle to the mid-fourteenth century.
I will compare four systems of logic with regard to their expressive power.
1. Aristotle’s own logic, based mostly on chapters 1-2 and 4-7 of his Prior Analytics
2. An expanded version of Aristotle’s logic that one finds, e.g., in Sherwood’s Introduction to Logic and Peter of Spain’s Tractatus
3-5. Versions of the logic of later supposition theorists such as William Ockham, John Buridan, and Paul of Venice. Version 4 is the logic without relatives (anaphoric pronouns); version 5 adds relatives.
I am ignoring modals, conditionals that are not ut nunc, infinitizing negation, exclusives and exceptives, all exponibles, all insolubles, and terms with simple or material supposition, ampliation and restriction, and many other things.
Cornering Law
Authors: Helton William S. , Head James , Blaschke Benno A. 
Published: June 2013

Objective: We investigated skill development and workload of pilots driving teleoperated unmanned ground vehicles (UGVs) through different apertures and viewpoints using the cornering law. Background: Due to technological and cost restraints, humans are still needed for tasks involving UGVs. Operators of teleoperated UGVs are likely to have less situation awareness and thus are more prone to getting stuck or damaged when negotiating apertures. To our knowledge, the operation of physical UGVs through corners has not been examined. Therefore, a better understanding of cornering a teleoperated UGVs is imperative. Method: In Experiment 1, 20 novice participants repeatedly teleoperated a physical UGV using a third-person overhead view through apertures that varied in width. In Experiment 2, 18 additional novice participants completed a similar task but used a first-person view. Results: Participants’ performance increased (i.e., faster cornering times and less collisions) over sessions. The cornering law successfully modeled the effect of different aperture widths on participant performance for both viewing perspectives. Conclusion: In this study, we successfully modeled human performance of teleoperated UGVs using the cornering law. Analogous to Fitts’ and steering law, we were able to successfully model and predict cornering performance based on a derived index of cornering difficulty. Application: The cornering law could be used to aid in the development of prototype user interfaces and also to examine the effects of different teleoperation views (first person vs. third person).
Costal Cartilage Is a Superior Implant Material than Conchal Cartilage in the Treatment of Empty Nose Syndrome
Authors: Jung Jae Hoon , Baguindali Mohammad Ariff , Park Jin Taek , Jang Yong Ju 
Published: June 2013

ObjectiveThe objective of this study was to evaluate the outcomes of endonasal microplasty in treating empty nose syndrome by comparing the use of costal and conchal cartilage implants to construct neoturbinates.Study DesignCase series with chart review.SettingTertiary referral center.Subjects and MethodsA total of 31 patients who were diagnosed with empty nose syndrome and underwent endonasal microplasty with conchal cartilage (n = 17) or costal cartilage implants (n = 14) were included. Each patient's clinico‐demographic profile was reviewed to compare the conchal cartilage group and the costal cartilage groups. Pre‐ and postoperative Sino‐Nasal Outcome Test (SNOT‐25) scores were also compared.ResultsBoth groups showed a significant improvement in SNOT‐25 scores following surgery (P <. 05). The group who received costal cartilage implants demonstrated more significant improvements than the conchal cartilage group in terms of the mean difference between pre‐ and postoperative SNOT‐25 scores (P =. 023). Symptom outcomes related to depression demonstrated significant improvements in the conchal cartilage group (P <. 05), while in the costal cartilage group, in addition to these 3 variables, 7 items related to functional problems also demonstrated significant improvements (P <. 05).ConclusionsCostal cartilage is a more useful material than conchal cartilage as implants for the treatment of empty nose syndrome patients.
Social support, social strain, loneliness, and well-being among older adults
Authors: Chen Yixin , Feeley Thomas Hugh 
Published: June 2013

This study proposed that, among older adults, higher support and lower strain received from each of the four relational sources (spouse/partner, children, family, and friends) were associated with reduced loneliness and improved well-being and that loneliness might mediate the relationship between support/strain and well-being. Structural equation modeling was conducted using a national sample of adults aged 50 years and older ( N = 7,367) from the Health and Retirement Study. Findings indicated that support from spouse/partner and friends alleviated loneliness, while strain from all the four sources intensified loneliness; higher support and lower strain from various sources directly and indirectly improved well-being, with indirect effects mediated through reduced loneliness. It was concluded that, in later life, various sources of support/strain engender distinct effects on loneliness and well-being, and loneliness serves as one of the psychological pathways linking support/strain to well-being.
Comparison of Bone Tunnel and Suture Anchor Techniques in the Modified Broström Procedure for Chronic Lateral Ankle Instability
Authors: Hu Chang-Yong , Lee Keun-Bae , Song Eun-Kyoo , Kim Myung-Sun , Park Kyung-Soon 
Published: June 2013

Background: The modified Broström procedure is frequently used to treat chronic lateral ankle instability. There are 2 common methods of the modified Broström procedure, which are the bone tunnel and suture anchor techniques. Purpose: To compare the clinical outcomes of the modified Broström procedure using the bone tunnel and suture anchor techniques. Study Design: Cohort study; Level of evidence, 2. Methods: Eighty-one patients (81 ankles) treated with the modified Broström procedure for chronic lateral ankle instability constituted the study cohort. The 81 ankles were divided into 2 groups, namely, a bone tunnel technique (BT group; 40 ankles) and a suture anchor technique (SA group; 41 ankles). The Karlsson score, American Orthopaedic Foot and Ankle Society (AOFAS) ankle-hindfoot score, anterior talar translation, and talar tilt angle were used to evaluate clinical and radiographic outcomes. The BT group consisted of 32 men and 8 women with a mean age of 34.8 years at surgery and a mean follow-up duration of 34.2 months. The SA group consisted of 33 men and 8 women with a mean age of 33.3 years at surgery and a mean follow-up duration of 32.8 months. Results: Mean Karlsson scores improved significantly from 57.0 points preoperatively to 94.9 points at final follow-up in the BT group and from 59.9 points preoperatively to 96.4 points at final follow-up in the SA group. Mean AOFAS scores also improved from 64.2 points preoperatively to 97.8 points at final follow-up in the BT group and from 70.3 points preoperatively to 97.4 points at final follow-up in the SA group. Mean anterior talar translations in the BT group and SA group improved from 9.0 mm and 9.2 mm preoperatively to 6.5 mm and 6.8 mm at final follow-up, respectively. Mean talar tilt angles were 12.0° in the BT group and 12.5° in the SA group preoperatively and 8.8° at final follow-up for both groups. No significant differences were found between the 2 groups in terms of the Karlsson score, AOFAS score, anterior talar translation, and talar tilt angle. Conclusion: The bone tunnel and suture anchor techniques of the modified Broström procedure showed similar good functional and radiographic outcomes. Both techniques appear to be effective and reliable methods for the treatment of chronic lateral ankle instability.
Platelet Hyperaggregability is Highly Prevalent in Patients With Chronic Kidney Disease
Authors: Yagmur Eray , Frank Rolf Dario , Neulen Joseph , Floege Jürgen , Mühlfeld Anja Susanne 
Published: June 2013

Background: Platelet hyperaggregation is known to be associated with arterial and venous thromboembolic events. The prevalence of platelet hyperaggregation in patients with chronic kidney disease (CKD) has not been described to date. Methods: Platelet hyperaggregation in patients with renal disease was defined by comparison of platelet aggregation patterns to non-CKD patients without thromboembolic disorders and healthy controls. Results: Among the 30 hemodialysis patients and 34 renal transplant recipients, 20 (67%) and 28 (82%) showed significantly decreased median Δ-epinephrine aggregation and increased 0.5 mol/L epinephrine response (65% and 54%) compared to healthy controls and non-CKD patients. In concordance to the laboratory finding of platelet hyperaggregability, renal transplant recipients showed a high rate of thromboembolic events (normal platelet aggregation: 0 events and platelet hyperaggregation: 30 events in 13 of 28 patients). Conclusions: Patients with CKD exhibit a hitherto unappreciated high prevalence of platelet hyperaggregability indicating sticky platelet syndrome. Laboratory testing of platelet hyperaggregability may supplement the assessment of thromboembolic complications in patients with CKD.
An underused opportunity to introduce ACE inhibitors and influence prognosis: observational study of patients undergoing aortic surgery
Authors: Muttardi Kayria , Haydar Ali , Phua Chee Kiang , Chapman Neil , Jenkins Michael , Cheshire Nicholas JW , Bicknell Colin D 
Published: June 2013

Objective To asses whether Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are underused in patients with aortic disease due to concerns regarding flow limiting (>70%) renal artery stenosis (RAS). Design A prospective analysis of patients admitted for aortic surgery was performed (January–July 2009). Co-morbidity, ACEI/ARB use and renal function were recorded. Computerised tomography (CT) angiograms were reviewed by a single blinded radiologist for the presence and severity of RAS. Setting St Mary's Hospital, Vascular Unit, Imperial College Healthcare NHS Trust, London, UK. Participants 75 randomly selected patients admitted to our vascular unit including elective and emergency admissions. Main outcome measures Indications for ACEI therapy were identified as determined by the National Institute of Health and Clinical Excellence (NICE) guidance. The ratio of the measurement distal to the stenosis and at the area of maximal stenosis on CT angiography were used to calculate the percentage RAS. Results 60 patients were identified (15 patients excluded due to previously modified renal vessels). The median age was 73 [interquartile range 68, 77]. Their underlying aortic disease included 52 (87%) aortic aneurysm, 6 (10%) with aortic dissection, 1 (1.7%) patient with occlusive disease and 1 (1.7%) patient with mycotic disease. Overall, 56/60 (93%) patients had at least one indication for ACEI therapy. 33/60 (55%) of patients were already receiving ACEI. CT angiogram examination demonstrated 17/60 (28%) patients have RAS of some degree, of which only 9/60 (15%) have flow limiting RAS. Conclusion A large proportion of aortic patients do not receive ACEI/ARB therapy despite definite indications and a low prevalence of flow-limiting RAS is low. After the exclusion of RAS at angiography, careful introduction of ACEI therapy with appropriate monitoring could be considered for many more patients.
A semi-automated genome annotation comparison and integration scheme
Authors: Liu Zhe , Ma Hongwu , Goryanin Igor 
Published: June 2013

Abstract

Background
Different genome annotation services have been developed in recent years and widely used. However, the functional annotation results from different services are often not the same and a scheme to obtain consensus functional annotations by integrating different results is in demand.

Results
This article presents a semi-automated scheme that is capable of comparing functional annotations from different sources and consequently obtaining a consensus genome functional annotation result. In this study, we used four automated annotation services to annotate a newly sequenced genome--Arcobacter butzleri ED-1. Our scheme is divided into annotation comparison and annotation determination sections. In the functional annotation comparison section, we employed gene synonym lists to tackle term difference problems. Multiple techniques from information retrieval were used to preprocess the functional annotations. Based on the functional annotation comparison results, we designed a decision tree to obtain a consensus functional annotation result. Experimental results show that our approach can greatly reduce the workload of manual comparison by automatically comparing 87% of the functional annotations. In addition, it automatically determined 87% of the functional annotations, leaving only 13% of the genes for manual curation. We applied this approach across six phylogenetically different genomes in order to assess the performance consistency. The results showed that our scheme is able to automatically perform, on average, 73% and 86% of the annotation comparison and determination tasks, respectively.

Conclusions
We propose a semi-automatic and effective scheme to compare and determine genome functional annotations. It greatly reduces the manual work required in genome functional annotation. As this scheme does not require any specific biological knowledge, it is readily applicable for genome annotation comparison and genome re-annotation projects.