bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adipose tissue displays trophic properties on normal lung cellular components without promoting cancer cells growth
Authors: Andriani F. , Facchinetti F. , Furia S. , Roz L. , Bursomanno S. , Bertolini G. , Carniti C. , Sozzi G. , Pastorino U. 
Published: November 2012

AbstractSurgical removal is the mainstay for early lung cancer treatment and persistent air leaks represent one of the most common clinical complications after lung surgery. Adipose tissue transplantation has been proposed as a new strategy for regenerative therapy after breast cancer surgery; however its efficacy and safety of lung tissue healing after lung resections are unknown. The purpose of this study was to test the biological activity of adipose tissue to facilitate lung tissue healing and evaluate its effect on cancer cells growth, thus providing insight for a possible clinical application. Different in vitro cellular models were used to prove the potential biologic effect of autologous fat tissue (AFT) in repairing injured lung tissue, and in vivo xenograft models were used to evaluate tumor promoting potential of AFT on putative residual cancer cells. Treatment of both embryonic (WI‐38) and adult lung fibroblasts and of normal bronchial epithelial cells (HBEC‐KT) with AFT samples, harvested from subcutaneous tissue layer of 20 patients undergoing pulmonary metastasectomy, improved wound healing and cell proliferation indicating a trophic effect on both mesenchymal and epithelial cell types. Conversely AFT‐conditioned medium was unable to stimulate in vitro proliferation of a lung adenocarcinoma reporter cellular system (A549). Moreover, co‐injection of AFT and A549 cells in nude mice did not promote engraftment and progression of A549 cells. These preclinical findings provide preliminary evidence on the potential efficacy of AFT to accelerate lung tissue repair without undesired tumor promoting effects on putative residual cancer cells. J. Cell. Physiol. 228: 1166–1173, 2013. © 2012 Wiley Periodicals, Inc.
HIPEC + EPIC versus HIPEC‐alone: Differences in major complications following cytoreduction surgery for peritoneal malignancy
Authors: McConnell Yarrow J. , Mack Lloyd A. , Francis Wesley P. , Ho Thomas , Temple Walley J. 
Published: November 2012

AbstractIntroductionPeritoneal metastases (PM) can be treated with cytoreduction surgery (CRS) with intraoperative heated intraperitoneal chemotherapy (HIPEC) plus or minus early postoperative intraperitoneal chemotherapy (EPIC). HIPEC + EPIC may be associated with more complications than HIPEC alone.MethodsA prospective database of consecutive patients undergoing CRS + HIPEC ± EPIC at the University of Calgary between February 2000 and May 2011 was reviewed. Patient, tumor, and perioperative variables included peritoneal cancer index (PCI), completeness of cytoreduction (CCR) score, HIPEC ± EPIC type, and grade III/IV complications.Results198 patients had a CCR score of 0/1 and received: (1) HIPEC mitomycin C + EPIC 5‐fluorouracil for 5 days (n = 85; February 2000–January 2008); or (2) HIPEC oxaliplatin with IV 5‐fluorouracil + no EPIC (n = 113; February 2008–May 2011). Clinicodemographics were similar except PCI was higher in the HIPEC‐alone group (mean PCI 22 vs. 17; P = 0.02). The rate of grade III/IV complications was higher in the HIPEC + EPIC group (44.7% vs. 31.0%; P = 0.05). On multivariate logistic regression only HIPEC + EPIC and PCI > 26 were associated with an increased rate of complications.ConclusionIn patients with PM, the use of EPIC, in combination with CRS and HIPEC, is associated with an increased rate of complications. Surgeons should consider using HIPEC only (without EPIC). J. Surg. Oncol. 2013;107:591–596. © 2012 Wiley Periodicals, Inc.
A note on integral Menger curvature for curves
Authors: Blatt Simon 
Published: November 2012

AbstractFor continuously differentiable embedded curves γ, we will give a necessary and sufficient condition for the boundedness of integral versions of the Menger curvature. We will show that for p > 3 the integral Menger curvature \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$\mathfrak {M}_p(\gamma )$\end{document} is finite if and only if γ belongs to the Sobolev Slobodeckij space \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$W^{2-\frac{2}{p},p}(\mathbb {R} / \mathbb {Z}, \mathbb {R}^n)$\end{document}. The quantity \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$\mathfrak {J}_p (\gamma )$\end{document} – defined by taking the supremum of the p‐th power of Menger curvature with respect to one variable and then integrating over the remaining two – is finite for p > 2, if and only if γ belongs to the space \documentclass{article}\usepackage{amssymb}\begin{document}\pagestyle{empty}$W^{2-\frac{1}{p},p}$\end{document}.
Burden of overactive bladder symptom on quality of life in stroke patients
Authors: Itoh Yoshiaki , Yamada Satoshi , Konoeda Fumie , Koizumi Kenzo , Nagata Hirohiko , Oya Mototsugu , Suzuki Norihiro 
Published: November 2012

AbstractAimsOveractive bladder (OAB) affects the daily life of many stroke victims. In contrast to urinary incontinence, little is known about the prevalence and risk factors for OAB among stroke patients. Therefore, we conducted a questionnaire survey and analyzed the results together with the clinical data and MRI findings.MethodsA total of 500 volunteer patients with chronic‐phase stroke were enrolled. The overactive bladder symptom score (OABSS), Short Form 8 (SF‐8) health survey questionnaire, and some key international questionnaires about urinary dysfunction were assessed.ResultsWe diagnosed 141 patients (28%) with OAB, among whom 103 (73%) had never been treated for their symptoms. Patients with OAB showed lower scores in both the physical and mental components of the SF‐8, which suggested the burden of OAB on the quality of life of stroke patients. Advanced age and male gender were closely related to high OABSS. The modified Rankin Scale (mRS) was positively correlated with OABSS. Patients with cerebral infarction and those with intracerebral hemorrhage showed a similarly high OABSS. The severity of deep white‐matter hyperintensity on MRI, classified by the 4‐grade Fazekas scoring system, was significantly associated with high OABSS irrespective of presence of accompanying infarcts. Patients with cerebral infarcts in the region of anterior circulation showed a higher OABSS than those with cerebral infarcts in the posterior circulation.ConclusionsBased on the present risk analysis, patient care should be preferentially focused on the detection and treatment of OAB to improve the quality of life of stroke patients. Neurourol. Urodynam. 32: 428–434, 2013. © 2012 Wiley Periodicals, Inc.
Correlation between cystometric volumes, ATP release, and pH in women with overactive bladder versus controls
Authors: Cheng Ying , Mansfield Kylie J. , Allen Wendy , Millard Richard J. , Burcher Elizabeth , Moore Kate H. 
Published: November 2012

AbstractAimsIn the bladder, ATP is an important signaling molecule, which is released by bladder stretch and acid. We hypothesized that ATP might play a unique role in patients with OAB, characterized by low bladder volumes at first desire to void (FDV) and maximal cystometric capacity (MCC) and symptoms of frequency/urgency [mild bladder pain syndrome (BPS)]. Our aim was to investigate the correlation between ATP release and urodynamic parameters, as well as urine pH, in OAB patients.MethodsRoutine cystometry was performed in a consecutive series of 249 women. The voided urodynamic fluid (VUF) was stored at −20°C and ATP measured using bioluminescence. Catheter urine was collected for pH measurement. Correlations between two factors were tested by linear regression analysis.ResultsSubjects with urinary tract infection, voiding dysfunction, and detrusor overactivity (DO) were excluded. For OAB patients (n = 25), there was an inverse correlation between ATP concentration in VUF and FDV (r2 = 0.25; P = 0.01) but not MCC. This was not seen in controls (n = 69). In OAB, but not controls, there was a significant reverse correlation (r2 = 0.16; P = 0.047) between ATP in VUF and urine pH. Urine pH was not significantly correlated with MCC in either group.ConclusionsIn OAB patients, ATP is an important factor for initial perception of need to urinate (as indicated by FDV). This is similar to our previous findings in patients with DO, suggesting that ATP may mediate initial afferent sensation in patients with bladder dysfunctions characterized by urgency. ATP release was also strongly affected by urine pH, in patients with OAB (at FDV). Neurourol. Urodynam. 32: 969–973, 2013. © 2012 Wiley Periodicals, Inc.
Anforderung an Entwicklung und Qualität von Biosimilars
Authors: Rais Isam 
Published: November 2012

AbstractBiosimilars sind Nachfolgeprodukte biotechnologisch hergestellter Arzneimittel und im weiteren Sinne als Generika zu verstehen. Sie können nach Ablauf des Patentschutzes von Pharmafirmen hergestellt werden und müssen in Hinblick auf Qualität, Sicherheit und Wirksamkeit mit dem am Markt befindlichen Referenzprodukt vergleichbar sein.
Hochleistungsanalytik für die Entwicklung von Biosimilars
Authors: Blüggel Martin 
Published: November 2012

AbstractDie Hochleistungsanalytik während der Entwicklungsphase eines Biosimilar erlaubt eine Ausrichtung auf die Qualität und Ähnlichkeit. Ein Biosimilar‐Kandidat wird detailliert auf Hunderte von Qualitätsattributen analysiert und mit dem Originator verglichen. Bei einzelnen eventuell vorhandenen Unterschieden wird deren Bedeutung für die Wirksamkeit und Sicherheit bewertet und ggf. experimentell belegt.Die bewährte europäische, regulatorische Vorgehensweise ist geprägt von einer wissenschaftlichen Herangehensweise. Die verbesserten analytischen Möglichkeiten sowie die Daten über und die Erfahrungen mit einem Wirkstoff durch die Vielzahl der Biosimilar‐Entwicklungen und den Originator selbst, führen zu einer viel genaueren Charakterisierung als dies für neue Entwicklungen allein möglich ist oder aufgrund des Stands der Technik zum Zeitpunkt der Zulassung der Originatoren möglich war. Die Hochleistungsanalytik liefert damit eine fundierte Grundlage für die Entscheidung über die Zulassung dieser nur ähnlichen Produkte.
Pharmaökonomische Aspekte von Biosimilars
Authors: Walter Evelyn 
Published: November 2012

Abstract2010 wurden in Deutschland 26 Arzneimittel mit neuen Wirkstoffen (international auch als NME – New Molecular Entity – bezeichnet) im Markt eingeführt. Bei den Ausgaben für Arzneimittel liegt Deutschland mit einem Anteil von 15,1 % an den gesamten Gesundheitsausgaben (rund 280 Mrd. Euro) nach wie vor deutlich unter dem Niveau der meisten europäischen Länder und Japans. Die Ausgaben der GKV für Arzneimittel betragen 32,0 Mrd. Euro oder 18 %. Von den Gesamtausgaben der GKV entfallen nur 4 % (6,7 Mrd. Euro) auf patentgeschützte Arzneimittel.
Progression‐free survival of two cases of high‐risk neuroblastoma with refractory/relapsed disease following surgery alone
Authors: Sokol Elizabeth , Haut Paul R. , Gosiengfiao Yasmin , Feinstein Kate , Pytel Peter , Cohn Susan L. 
Published: November 2012

AbstractOutcome for the vast majority of high‐risk neuroblastoma patients with refractory or relapsed disease is dismal. We report two high‐risk patients who remain progression‐free for more than 113 and 18 months following the diagnosis of refractory/relapsed disease who were treated with surgery alone. Complete resolution of a refractory thoracic mass and relapsed liver nodules was observed in one patient. The refractory/relapsed disease in the second patient has remained stable. In both cases, the tumor showed histologic evidence of neuroblastoma maturation. These cases demonstrate that refractory/relapsed neuroblastoma is clinically heterogeneous and highlight the need for better biomarkers to optimize patient care. Pediatr Blood Cancer 2013; 60: 512–514. © 2012 Wiley Periodicals, Inc.
Increasing use of atypical antipsychotics and anticonvulsants during pregnancy
Authors: Epstein Richard A. , Bobo William V. , Shelton Richard C. , Arbogast Patrick G. , Morrow James A. , Wang Wei , Chandrasekhar Rameela , Cooper William O. 
Published: November 2012

ABSTRACTPurposeTo quantify maternal use of atypical antipsychotics, typical antipsychotics, anticonvulsants, and lithium during pregnancy.MethodsTennessee birth and death records were linked to Tennessee Medicaid data to conduct a retrospective cohort study of 296 817 women enrolled in Tennessee Medicaid throughout pregnancy who had a live birth or fetal death from 1985 to 2005.ResultsDuring the study time period, the adjusted rate of use of any study medication during pregnancy increased from nearly 14 to 31 per 1000 pregnancies (β = 0.08, 95% CI = 0.07, 0.09). Significant increases were reported in use of anticonvulsants alone among mothers with pain and other psychiatric disorders, atypical antipsychotics alone among mothers with bipolar disorders, schizophrenia, unipolar depressive disorders, and other psychiatric disorders, and more than one studied medication for mothers with epilepsy, pain disorders, bipolar disorders, unipolar depressive disorders, and other psychiatric disorders. Significant decreases were reported in use of lithium alone and typical antipsychotics alone for all clinically meaningful diagnosis groups.ConclusionsThere was a substantial increase in use of atypical antipsychotics alone, anticonvulsants alone, and medications from multiple studied categories among Tennessee Medicaid‐insured pregnant women during the study period. Further examination of the maternal and fetal consequences of exposure to these medications during pregnancy is warranted. Copyright © 2012 John Wiley & Sons, Ltd.
Heiße Elektronik
Authors: Münzenberg Markus , Thomas Andy 
Published: November 2012

AbstractDer Seebeck‐Effekt wandelt einen Temperaturgradienten in eine Thermospannung um, umgekehrt funktioniert der Peltier‐Effekt. Kürzlich wurden in Nanostrukturen neuartige, verwandte Effekte entdeckt. Dazu gehört der Spin‐Seebeck‐Effekt in magnetischen Filmen und Tunnel‐Magneto‐Seebeck‐Effekt in magnetischen Tunnelelementen. Der Effekt ist in den nanoelektronischen Bauelementen stark genug für technische Anwendungen. Die Grundlagenforschung verspricht neue Erkenntnisse über das Zusammenspiel von elektrischen und thermischen Strömen mit dem Elektronenspin. In der Technik könnte die Spinkaloritronik bisher ungenutzte Abwärme, etwa von Automotoren oder Mikroprozessoren, zur Spannungsquelle für Bordelektroniken oder mobile Anwendungen machen.
Prost Neujahr: die Physik von Champagnerflaschen
Authors: Vollmer Michael , Möllmann Klaus‐Peter 
Published: November 2012

AbstractSekt und Champagner gehören zur Silvesterfeier wie ein prächtiges Feuerwerk. Physiker verfallen hierbei leicht in Diskussionen über die Wurfparabeln der Sektkorken oder das akustische Phänomen des Knalls. Hochgeschwindigkeitskameras eröffnen zusätzlich die Möglichkeit, sehr schnell ablaufende Prozesse bei der Handhabung der edlen Tropfen sichtbar zu machen, zum Beispiel die adiabatische Expansion des Treibgases.
Nanostructured Polymer Fibers with Enhanced Adhesion to Epoxy Matrices
Authors: Fernández‐Blázquez Juan P. , Setzer Sandro , del Campo Aránzazu 
Published: November 2012

AbstractA method for reinforcing the strength of the interface between a polymer fiber and a polymer matrix is described. PET fibers were etched in an oxidative plasma to generate a surface nanopattern. Depending on the plasma treatment time, lamellae patterns with different geometries were obtained. The interfacial shear strength (IFSS) between the fiber and a epoxy matrix was measured for the different surface topographies. A twofold increase in the IFSS was obtained for lamellae with 100 nm thickness, 300 nm height, and separated by 400 nm valleys. Our results demonstrate the benefit of a surface pattern for reinforcing the interface between fibers and resin. magnified image
Tri‐bimaximal neutrino mixing and discrete flavour symmetries
Authors: Altarelli G. , Feruglio F. , Merlo L. 
Published: November 2012

AbstractWe review the application of non‐Abelian discrete groups to Tri‐Bimaximal (TB) neutrino mixing, which is supported by experiment as a possible good first approximation to the data. After summarizing the motivation and the formalism, we discuss specific models, mainly those based on A4 but also on other finite groups, and their phenomenological implications, including the extension to quarks. The recent measurements of θ13 favour versions of these models where a suitable mechanism leads to corrections to θ13 that can naturally be larger than those to θ12 and θ23. The virtues and the problems of TB mixing models are discussed, also in connection with lepton flavour violating processes, and the different approaches are compared.
Quantum field theory analysis of polarizations correlations, entanglement and Bell's inequality: explicit processes
Authors: Yongram N. , Manoukian E.B. 
Published: November 2012

AbstractThis paper provides explicit and detailed quantum field theory (QFT) computations of polarizations correlations of emerging particles in several processes in QED, Electroweak Theory, and even in particle productions from strings, and hence are based on dynamical theries. The novel properties observed in the computations of such polarizations correlations, as predicted by QFT, is that they depend on the speed of the colliding particles, and, in some cases, even on coupling parameters ratios as well as on mass ratios of the underlying theory. These investigations clearly show that arguments based simply on combining spins to generate probabilities of such polarization correlations are not reliable. The novel properties obtained, with details of derivations provided here, hopefully would call for experiments on polarizations correlations which would monitor speeds of colliding particles, and, would, in turn, lead to new tests of the fundamental interactions of QFT such as of QED and of the Electroweak Theory.
HOXB13 mutations in a population‐based, case–control study of prostate cancer
Authors: Stott‐Miller Marni , Karyadi Danielle M. , Smith Tiffany , Kwon Erika M. , Kolb Suzanne , Stanford Janet L. , Ostrander Elaine A. 
Published: November 2012

AbstractBACKGROUNDProstate cancer (PC) is the most frequently diagnosed non‐skin malignancy in men in the Western world, yet few disease‐associated mutations have been found. Recently, a low frequency recurring mutation in the HOXB13 gene was reported among both hereditary PC families and men from the general population.MATERIALS AND METHODSWe determined the distribution and frequency of the G84E HOXB13 variant in 1,310 incipient PC cases and 1,259 age‐mated controls from a population‐based, case–control study of PC.RESULTSThe G84E mutation was more frequent in cases than controls (1.3% vs. 0.4%, respectively), and men with the HOXB13 G84E variant had a 3.3‐fold higher relative risk of PC compared with noncarriers (95% CI, 1.21–8.96). There was a stronger association between the G84E variant and PC among men with no first‐degree relative with PC (OR, 4.04; 95% CI, 1.12–14.51) compared to men with a family history of PC (OR, 1.49; 95% CI, 0.30–7.50; P = 0.36 for interaction). We observed some evidence of higher risk estimates associated with the variant for men with higher versus lower Gleason score (OR, 4.13; 95% CI, 1.38–12.38 vs. OR, 2.71; 95% CI, 0.88–8.30), and advanced versus local stage (OR, 4.47; 95% CI, 1.28–15.57 vs. OR, 2.98; 95% CI, 1.04–8.49), however these differences were not statistically different.CONCLUSIONSThese results confirm the association of a rare HOXB13 mutation with PC in the general population and suggest that this variant may be associated with features of more aggressive disease. Prostate 73: 634–641, 2013. © 2012 Wiley Periodicals, Inc.
Analysing the photoluminescence intensities of single‐walled carbon nanotubes
Authors: Heeg Sebastian , Abrahamson Joel T. , Strano Michael S. , Reich Stephanie 
Published: November 2012

AbstractWe study the photoluminescence and photoluminescence excitation intensities of single‐walled carbon nanotubes. To derive the chirality fractions of semiconducting tubes from these optical methods requires a thorough analysis of the experimental parameters and the lifetimes of the excitonic states. We obtain the intensity distribution from the product of the widths of the first and second excitonic transition and the intensity of the absorption of the second excited state. Compared with previous analysis protocols our intensity distribution points towards a chirality abundance which is (i) narrower in diameter, (ii) centred at smaller diameters and (iii) more strongly dominated by armchair‐like tubes. We present a recipe for the fit of luminescence data.
Effects of contact oxidization on the transport properties of Au/ZGNR junctions
Authors: Zhang C. X. , Xiao Huaping , He Chaoyu , Xue L. , Zhang K. W. , Sun L. Z. , Zhong Jianxin 
Published: November 2012

AbstractThe transport properties of the junction assembled by zigzag graphene nanoribbons (ZGNRs) and Au electrode (Au/ZGNR) are investigated using first‐principles calculations. It is found that the Au/ZGNR junction behaves as a typical diode with Schottky barrier at the contact. Our results indicate that although the oxidization at the contact slightly influences the Schottky barrier, the I –V characteristic is effectively modulated. Such effect derives from the impact of the oxidization on the coupling between the ZGNRs and Au electrode.magnified imageAu/ZGNR junction oxidized by C=O groups at the contact and relative I –V curves.(© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Transparent p‐NiO/n‐ZnO diodes used in circuit rectifiers
Authors: Bae Heesun , Lee Kyung Ha , Lee Kwang H. , Song Jong Han , Im Seongil 
Published: November 2012

AbstractWe report on the fabrication of a transparent photostable cell circuit composed of drive and resistor diodes which are face‐to‐face connected to each other with different device area. The diodes consisted of e‐beam evaporated p‐NiO on sputter‐deposited n‐ZnO for p/n diode formation on indium‐tin‐oxide glass. Our transparent diodes show photostable rectifying behavior, about 103 on/off current ratio and even dynamic rectification at a maximum frequency of 100 Hz AC input signal in ambient light. The noticeable photo‐responsivity of the circuit was obtained only under ultraviolet (UV) light. We conclude that our transparent diode circuit is promising in enriching the field of transparent device electronics. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)