bluuebunny/crossref_metadata_2025_split huggingface dataset:
Room‐temperature growth of ion‐induced Si‐ and Ge‐incorporated carbon nanofibers
Authors: Yaakob Yazid , Kuwataka Yu , Yusop Mohd Zamri Mohd , Tanaka Shihomi , Rosmi Mohamad Saufi , Kalita Golap , Tanemura Masaki 
Published: February 2015

We have demonstrated the fabrication of Si‐ and Ge‐incorporated carbon nanofibers (CNFs) at room temperature. Graphite foil surfaces were irradiated by Ar+ and Ne+ ions with simultaneous Si and Ge supply, and the dependences of the ion‐induced composite CNFs surface morphology on the ion species and type of incorporated materials were investigated. The sample surfaces were characterized by various kinds of densely distributed nanostructures, such as conical protrusions, nanoneedles, nanocones, and CNF‐tipped cones, depending on the Si and Ge supply rates during ion irradiation. In addition, Ne+ irradiation yielded longer CNFs compared to Ar+‐irradiated CNFs. Thus, the nanostructures growth was controllable by adjusting the ion and material species.Surface morphology of ion‐induced Ge‐incorporated CNFs.
Income Inequality and the Online Reading Gap
Authors: Leu Donald J. , Forzani Elena , Kennedy Clint 
Published: February 2015

AbstractA recent study in Reading Research Quarterly provided evidence that an online reading achievement gap, based on income inequality, exists that is separate and independent from the well‐known achievement gap in offline reading. This column briefly reviews the evidence and provides an initial set of instructional suggestions that may be used to help close the gap.
First two unrelated cases of isolated sedoheptulokinase deficiency: A benign disorder?
Authors: Wamelink Mirjam M. C. , Ramos Ruben J. J. F. , den van Elzen Annette P. M. , Ruijter George J. G. , Bonte Ramon , Diogo Luisa , Garcia Paula , Neves Nelson , Nota Benjamin , Haschemi Arvand , Tavares de Almeida Isabel , Salomons Gajja S. 
Published: February 2015

AbstractWe present the first two reported unrelated patients with an isolated sedoheptulokinase (SHPK) deficiency. The first patient presented with neonatal cholestasis, hypoglycemia, and anemia, while the second patient presented with congenital arthrogryposis multiplex, multiple contractures, and dysmorphisms. Both patients had elevated excretion of erythritol and sedoheptulose, and each had a homozygous nonsense mutation in SHPK. SHPK is an enzyme that phosphorylates sedoheptulose to sedoheptulose‐7‐phosphate, which is an important intermediate of the pentose phosphate pathway. It is questionable whether SHPK deficiency is a causal factor for the clinical phenotypes of our patients. This study illustrates the necessity of extensive functional and clinical workup for interpreting a novel variant, including nonsense variants.
Perceptions of Tissue Storage in a Dementia Population Among Spouses and Offspring
Authors: Martin Megan M. , Rothwell Erin W. , Venne Vickie L. , Foster Norman L. 
Published: February 2015

AbstractCognitively impaired patients with dementia often rely on health advocates or guardians, such as spouses or adult offspring, to consent for medical procedures. These family members may also decide whether an autopsy is performed after death or whether their family member donates tissues. However, spouses are not genetically related to the patient and may have different perspectives than genetically related family members when making medical decisions with genetic implications, such as participation in a tissue repository (biobank). Interviews were conducted with spouses and adult offspring of individuals with a progressive dementing disease. Both spouses and offspring were supportive of the patient with dementia to participate in tissue storage. The top perceived benefits of tissue storage in both offspring and spouses were future value for family members and advancement of medical knowledge. Concerns included misuse of the tissue and insurance discrimination. Although the personal genetic implications differ between spouses and offspring, they share similar attitudes about the importance of tissue banking for the individual with a dementing disease.
Numerical simulations of aggregate breakup in bounded and unbounded turbulent flows
Authors: Babler Matthaus U. , Biferale Luca , Brandt Luca , Feudel Ulrike , Guseva Ksenia , Lanotte Alessandra S. , Marchioli Cristian , Picano Francesco , Sardina Gaetano , Soldati Alfredo , Toschi Federico 
Published: February 2015

AbstractBreakup of small aggregates in fully developed turbulence is studied by means of direct numerical simulations in a series of typical bounded and unbounded flow configurations, such as a turbulent channel flow, a developing boundary layer and homogeneous isotropic turbulence. The simplest criterion for breakup is adopted, whereby aggregate breakup occurs when the local hydrodynamic stress ${\it\sigma}\sim {\it\varepsilon}^{1/2}$, with ${\it\varepsilon}$ being the energy dissipation at the position of the aggregate, overcomes a given threshold ${\it\sigma}_{cr}$, which is characteristic for a given type of aggregate. Results show that the breakup rate decreases with increasing threshold. For small thresholds, it develops a scaling behaviour among the different flows. For high thresholds, the breakup rates show strong differences between the different flow configurations, highlighting the importance of non-universal mean-flow properties. To further assess the effects of flow inhomogeneity and turbulent fluctuations, the results are compared with those obtained in a smooth stochastic flow. Furthermore, we discuss the limitations and applicability of a set of independent proxies.
Depth-integrated equation for hydro-acoustic waves with bottom damping
Authors: Abdolali Ali , Kirby James T. , Bellotti Giorgio 
Published: February 2015

AbstractWe present a depth-integrated equation for the mechanics of generation, propagation and dissipation of low-frequency hydro-acoustic waves due to sudden bottom displacement in a weakly compressible ocean overlying a weakly compressible viscous sediment layer. The model is validated against a full 3D computational model. Physical properties of these waves are studied and compared with those for waves over a rigid sea bed, revealing changes in the frequency spectrum and modal peaks. The resulting model equation can be used for numerical prediction in large-scale domains, overcoming the computational difficulties of 3D models while taking into account the role of bottom dissipation on hydro-acoustic wave generation and propagation.
Second language speech production: Investigating linguistic correlates of comprehensibility and accentedness for learners at different ability levels
Authors: SAITO KAZUYA , TROFIMOVICH PAVEL , ISAACS TALIA 
Published: February 2015

ABSTRACTThe current project aimed to investigate the potentially different linguistic correlates of comprehensibility (i.e., ease of understanding) and accentedness (i.e., linguistic nativelikeness) in adult second language (L2) learners’ extemporaneous speech production. Timed picture descriptions from 120 beginner, intermediate, and advanced Japanese learners of English were analyzed using native speaker global judgments based on learners’ comprehensibility and accentedness, and then submitted to segmental, prosodic, temporal, lexical, and grammatical analyses. Results showed that comprehensibility was related to all linguistic domains, and accentedness was strongly tied with pronunciation (specifically segmentals) rather than lexical and grammatical domains. In particular, linguistic correlates of L2 comprehensibility and accentedness were found to vary by learners’ proficiency levels. In terms of comprehensibility, optimal rate of speech, appropriate and rich vocabulary use, and adequate and varied prosody were important for beginner to intermediate levels, whereas segmental accuracy, good prosody, and correct grammar featured strongly for intermediate to advanced levels. For accentedness, grammatical complexity was a feature of intermediate to high-level performance, whereas segmental and prosodic variables were essential to accentedness across all levels. These findings suggest that syllabi tailored to learners’ proficiency level (beginner, intermediate, or advanced) and learning goal (comprehensibility or nativelike accent) would be advantageous for the teaching of L2 speaking.
Larger chimpanzee-dispersed seeds are elongated at Mahale, Tanzania: possible consequence of plant–disperser interaction?
Authors: Nakamura Michio , Itoh Noriko 
Published: February 2015

Abstract:Apes are important long-distance dispersers of large seeds in African tropical forests. Seed size and shape are likely to affect the ease of swallowing for an animal species. If an endozoochorous seed is larger than the digestive tract of an animal, the seed cannot be swallowed, and a round seed is more difficult to swallow than an elongated seed of the same length. In order to test if such a correlation exists between the seed size and its shape, we investigated the length and width of chimpanzee-dispersed seeds at the Mahale Mountains National Park, Tanzania. Among the 14 species of seeds, longer seeds had significantly narrower relative widths, and thus, they were more ovoid. Since the chimpanzee is the largest arboreal frugivore at Mahale, their food selection might have influenced the shape of larger seeds. The chimpanzee's selective consumption of such fruits with longer, elongated seeds may have facilitated the selective dispersal of such plant species in that area.
Clinical predictors of disease severity during the 2009–2010 A(HIN1) influenza virus pandemic in a paediatric population
Authors: GARCIA M. N. , PHILPOTT D. C. , MURRAY K. O. , ONTIVEROS A. , REVELL P. A. , CHANDRAMOHAN L. , MUNOZ F. M. 
Published: February 2015

SUMMARYA novel influenza virus emerged in the United States in spring 2009, rapidly becoming a global pandemic. Children were disproportionally affected by the novel influenza A(H1N1) pandemic virus [A(H1N1)pdm]. This retrospective electronic medical record review study aimed to identify clinical predictors of disease severity of influenza A(HIN1)pdm infection in paediatric patients. Disease severity was defined on an increasing three-level scale from non-hospitalized, hospitalized, and admitted to the intensive care unit (ICU). From April 2009 to June 2010, 696 children presented to Texas Children's Hospital's emergency department, 38% were hospitalized, and 17% were admitted to the ICU. Presenting symptoms associated with severe influenza were dyspnoea [odds ratio (OR) 5·82], tachycardia (OR 2·61) and fatigue (OR 1·96). Pre-existing health conditions associated with disease severity included seizure disorder (OR 4·71), obesity (OR 3·28), lung disease (OR 2·84), premature birth (OR 2·53), haematological disease (OR 2·22), and developmental delay (OR 2·20). According to model fitness tests, presenting symptoms were more likely to predict severe influenza than underlying medical conditions. However, both are important risk factors. Recognition of clinical characteristics associated with severe disease can be used for triaging case management of children during future influenza outbreaks.
Developmental mediation of genetic variation in response to the Fast Track prevention program
Authors: Albert Dustin , Belsky Daniel W. , Crowley D. Max , Bates John E. , Pettit Gregory S. , Lansford Jennifer E. , Dick Danielle , Dodge Kenneth A. 
Published: February 2015

AbstractWe conducted a developmental analysis of genetic moderation of the effect of the Fast Track intervention on adult externalizing psychopathology. The Fast Track intervention enrolled 891 children at high risk to develop externalizing behavior problems when they were in kindergarten. Half of the enrolled children were randomly assigned to receive 10 years of treatment, with a range of services and resources provided to the children and their families, and the other half to usual care (controls). We previously showed that the effect of the Fast Track intervention on participants' risk of externalizing psychopathology at age 25 years was moderated by a variant in the glucocorticoid receptor gene. Children who carried copies of the A allele of the single nucleotide polymorphism rs10482672 had the highest risk of externalizing psychopathology if they were in the control arm of the trial and the lowest risk of externalizing psychopathology if they were in the treatment arm. In this study, we test a developmental hypothesis about the origins of this for better and for worse Gene × Intervention interaction (G × I): that the observed G × I effect on adult psychopathology is mediated by the proximal impact of intervention on childhood externalizing problems and adolescent substance use and delinquency. We analyzed longitudinal data tracking the 270 European American children in the Fast Track randomized control trial with available genetic information (129 intervention children, 141 control group peers, 69% male) from kindergarten through age 25 years. Results show that the same pattern of for better and for worse susceptibility to intervention observed at the age 25 follow-up was evident already during childhood. At the elementary school follow-ups and at the middle/high school follow-ups, rs10482672 predicted better adjustment among children receiving the Fast Track intervention and worse adjustment among children in the control condition. In turn, these proximal G × I effects early in development mediated the ultimate G × I effect on externalizing psychopathology at age 25 years. We discuss the contribution of these findings to the growing literature on genetic susceptibility to environmental intervention.
Genetic differential susceptibility on trial: Meta-analytic support from randomized controlled experiments
Authors: van Ijzendoorn Marinus H. , Bakermans-Kranenburg Marian J. 
Published: February 2015

AbstractThe most stringent test of differential susceptibility theory is provided by randomized control trials examining the moderating role of genetic markers of differential susceptibility in experimental manipulations of the environment (Gene ×ExperimentalEnvironment interactions), being at least 10 times more powerful than correlational Gene × Environment interaction studies. We identified 22 experiments involving 3,257 participants with various developmental outcomes (e.g., externalizing problems, internalizing behaviors, and cognitive development). Effect sizes contrasting experimental versus control group were computed both for subjects with the polymorphism considered indicative of heightened susceptibility (e.g., the dopamine receptor D4 gene seven-repeat allele and the serotonin transporter polymorphic region short allele) and others expected to be low in susceptibility (e.g., the dopamine receptor D4 gene four-repeat allele and the serotonin transporter polymorphic region short allele). Clear-cut experimental support for genetic differential susceptibility emerged: the combined effect size of the interventions for the susceptible genotypes amounted tor= .33 (95% confidence interval = 0.23, 0.42;p< .01) versus a nonsignificantr= .08 (95% confidence interval = −0.02, 0.17;p= .12) for the hypothesized nonsusceptible genotypes. Macrotrials showed more evidence of genetic differential susceptibility than microtrials, and differential susceptibility was more clearly observed in trials with externalizing and cognitive outcomes than with internalizing problems. This meta-analysis shows proof of principle for genetic differential susceptibility and indicates that it is time to explore its mechanisms and limits. The concept of differential susceptibility alters the idea of constitutional “risk” factors (reactive temperament and risk genotypes), and points to intervention efficacy hidden in Gene × Environment interactions.
Measuring Sperm Movement within the Female Reproductive Tract using Fourier Analysis
Authors: Nicovich Philip R. , Macartney Erin L. , Whan Renee M. , Crean Angela J. 
Published: February 2015

AbstractThe adaptive significance of variation in sperm phenotype is still largely unknown, in part due to the difficulties of observing and measuring sperm movement in its natural, selective environment (i.e., within the female reproductive tract). Computer-assisted sperm analysis systems allow objective and accurate measurement of sperm velocity, but rely on being able to track individual sperm, and are therefore unable to measure sperm movement in species where sperm move in trains or bundles. Here we describe a newly developed computational method for measuring sperm movement using Fourier analysis to estimate sperm tail beat frequency. High-speed time-lapse videos of sperm movement within the female tract of the neriid flyTelostylinus angusticolliswere recorded, and a map of beat frequencies generated by converting the periodic signal of an intensity versus time trace at each pixel to the frequency domain using the Fourier transform. We were able to detect small decreases in sperm tail beat frequency over time, indicating the method is sensitive enough to identify consistent differences in sperm movement. Fourier analysis can be applied to a wide range of species and contexts, and should therefore facilitate novel exploration of the causes and consequences of variation in sperm movement.
Analysis of pig breeding management and trait preferences in smallholder production systems in Kenya
Authors: Mbuthia J.M. , Rewe T.O. , Kahi A.K. 
Published: February 2015

SummaryData on breeding management, breed and trait preference for pigs were collected from smallholder farmers in Kiambu and Kakamega Counties of Kenya. The production systems evaluated were semi-intensive and extensive and depicted varying pig production intensities, production objectives, pig performances as well as farmers’ breed and trait preferences. The perception of the importance of traits was evaluated to obtain a more balanced objective view on production and/or breeding objectives. The data collected were analysed through computation of indices, which represented a weighted average of all rankings of a particular trait. In the semi-intensive system, preference for performance traits such as size, growth rate and body weight, scored the same index (0.181), followed by the reproduction trait – prolificacy (0.161). In the extensive system, the indices for these traits were 0.187, 0.183, 0.163 and 0.106, respectively. Spearman's non-parametric rank correlations were calculated for ranking of traits of economic importance to indicate the directional effects and plausible trade-offs between traits. In the semi-intensive system, correlations were moderate between growth rate and both size and weight. In the extensive system, correlations were moderate for growth rate with both size and body weight. Appropriate breeds that suit the divergent production systems need to be identified and utilized based on performance and adaptability to ensure efficient resource use.
Targeting protein tyrosine phosphatase σ after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias
Authors: Gardner R. T. , Wang L. , Lang B. T. , Cregg J. M. , Dunbar C. L. , Woodward W. R. , Silver J. , Ripplinger C. M. , Habecker B. A. 
Published: February 2015

AbstractMillions of people suffer a myocardial infarction (MI) every year, and those who survive have increased risk of arrhythmias and sudden cardiac death. Recent clinical studies have identified sympathetic denervation as a predictor of increased arrhythmia susceptibility. Chondroitin sulfate proteoglycans present in the cardiac scar after MI prevent sympathetic reinnervation by binding the neuronal protein tyrosine phosphatase receptor σ (PTPσ). Here we show that the absence of PTPσ, or pharmacologic modulation of PTPσ by the novel intracellular sigma peptide (ISP) beginning 3 days after injury, restores sympathetic innervation to the scar and markedly reduces arrhythmia susceptibility. Using optical mapping we observe increased dispersion of action potential duration, supersensitivity to β-adrenergic receptor stimulation and Ca2+ mishandling following MI. Sympathetic reinnervation prevents these changes and renders hearts remarkably resistant to induced arrhythmias.
An HDAC-dependent epigenetic mechanism that enhances the efficacy of the antidepressant drug fluoxetine
Authors: Schmauss C. 
Published: February 2015

AbstractDepression is a prevalent and debilitating psychiatric illnesses. However, currently prescribed antidepressant drugs are only efficacious in a limited group of patients. Studies on Balb/c mice suggested that histone deacetylase (HDAC) inhibition may enhance the efficacy of the widely-prescribed antidepressant drug fluoxetine. This study shows that reducing HDAC activity in fluoxetine-treated Balb/c mice leads to robust antidepressant and anxiolytic effects. While reducing the activity of class I HDACs 1 and 3 led to antidepressant effects, additional class II HDAC inhibition was necessary to exert anxiolytic effects. In fluoxetine-treated mice, HDAC inhibitors increased enrichment of acetylated histone H4 protein and RNA polymerase II at promotor 3 of the brain-derived neurotrophic factor (Bdnf) gene and increased Bdnf transcription from this promotor. Reducing Bdnf-stimulated tropomyosin kinase B receptor activation in fluoxetine-treated mice with low HDAC activity abolished the behavioral effects of fluoxetine, suggesting that the HDAC-triggered epigenetic stimulation of Bdnf expression is critical for therapeutic efficacy.
In vitro plant regeneration of Aster scaber via somatic embryogenesis
Authors: Boo Kyung Hwan , Cao Dang Viet , Pamplona Reniel S , Lee Doseung , Riu Key-Zung , Lee Dong-Sun 
Published: February 2015

Abstract
We established an in vitro plant regeneration system via somatic embryogenesis of Aster scaber, an important source of various biologically active phytochemicals. We examined the callus induction and embryogenic capacities of three explants, including leaves, petioles, and roots, on 25 different media containing different combinations of α-naphthalene acetic acid (NAA) and 6-benzyladenine (BA). The optimum concentrations of NAA and BA for the production of embryogenic calli were 5.0 μM and 0.05 μM, respectively. Media containing higher concentrations of auxin and cytokinin (such as 25 μM NAA and 25 μM BA) were suitable for shoot regeneration, especially for leaf-derived calli, which are the most readily available calli and are highly competent. For root induction from regenerated shoots, supplemental auxin and/or cytokinin did not improve rooting, but instead caused unwanted callus induction or retarded growth of regenerated plants. Therefore, plant growth regulator-free medium was preferable for root induction. Normal plants were successfully obtained from calli under the optimized conditions described above. This is the first report of the complete process of in vitro plant regeneration of A. scaber via somatic embryogenesis.