bluuebunny/crossref_metadata_2025_split huggingface dataset:
Focusing a history of modern philosophy course on freedom
Authors: Protevi John 
Published: July 2024

AbstractThis article is on pedagogy; it is not a report on original research. It is a case study, seeking to spell out some implications for teaching History of Modern Philosophy (HMP). In past courses, I used a classic syllabus: Descartes, Spinoza, Leibniz, Locke, Hume, and Kant, focusing on epistemology and metaphysics, telling the standard story of rationalists and empiricists, with Kant breaking the stalemate with his transcendental arguments. After a few times, for circumstantial reasons, I changed the focus of the course. Instead of telling the usual story, I would focus on freedom in its metaphysical, moral, and political dimensions. This had the effect of giving the philosophy majors enough metaphysics and epistemology to make them work hard, while appealing to (some of) the General Education students by relating the course materials to real world struggles. I figured that some people who could not relate to the technical discussion of substance, attribute, and mode might relate to struggles for freedom. I think I succeeded, as I will go on to recount.
Identifying the genetic association between common rheumatic diseases and vitiligo
Authors: Zhao Mingming , Zhang Yuanyuan , Sun Guoxun 
Published: July 2024

AbstractBackgroundAlthough observational studies have suggested a correlation between vitiligo and rheumatic diseases, conclusive evidence supporting a causal relationship is still lacking. Therefore, this study aims to explore the potential causal relationship between vitiligo and rheumatic diseases.MethodsUsing genome‐wide association studies, we performed a two‐sample Mendelian randomization (MR) analysis. In our analysis, the random‐effects inverse variance weighted (IVW) method was predominantly employed, followed by several sensitivity analyses, which include heterogeneity, horizontal pleiotropy, outliers, and “leave‐one‐out” analyses.ResultsThe genetically predicted vitiligo was associated with an increased risk of rheumatoid arthritis (RA) (OR, 1.47; 95% confidence interval [CI], 1.29–1.68; p < 0.001), and systemic lupus erythematosus (SLE) (OR, 1.22; 95% CI, 1.06–1.39; p = 0.005). The causal associations were supported by sensitivity analyses. In Sjögren's syndrome and ankylosing spondylitis, no causal relationship with vitiligo was found in the study.ConclusionOur MR results support the causal effect that vitiligo leads to a higher risk of RA and SLE. Individuals with vitiligo should be vigilant for the potential development of RA and SLE. Managing and addressing this potential requires regular monitoring.
Instructional supports can reveal the word‐problem solving challenges of children with language difficulties
Authors: Barilaro Mélanie , Osana Helena P. , Ebbels Susan H. , Nicoll Hilary , Achim Éloïse , Pétel‐Despots Ariane , Lafay Anne 
Published: July 2024

AbstractSolving word problems is challenging for many children, but particularly for those with language difficulties. The objective was to examine the nature of the challenges experienced by children with language difficulties as they solved word problems in the context of a developmental‐trajectory instructional sequence. We recruited 45 third graders with (n = 17) and without (n = 28) language difficulties from public and private schools and one speech‐language therapy clinic. They solved word problems with additive change and compare structures and language that was either consistent or inconsistent with the structure. The instruction was based on successive simplifications to the problems whenever the child was unable to apply a structurally appropriate strategy: removing irrelevant literal information from the problem, simplifying the text syntactically, and removing irrelevant numerical information. The performance of children with language difficulties was lower than that of the typically developing children and the simplifications did not support performance to the same extent. The presence of irrelevant numerical information was challenging, especially for children with language difficulties. Removing irrelevant information from the problem was followed by stronger performance on change problems and those with consistent language, revealing that the instructional supports were not sufficient for compare and inconsistent problems.
Sprint interval training in the postpartum period maintains the enhanced cardiac output of pregnancy: A case study
Authors: Richard Normand , Claydon Victoria , Koehle Michael , Coté Anita 
Published: July 2024

AbstractDuring pregnancy an increased cardiac output () and blood volume (BV) occur to support fetal growth. Increased and BV also occur during chronic endurance exercise training and benefit performance. We investigated if sprint interval training (SIT) undertaken early postpartum maintains the elevated and BV of pregnancy and benefits performance. The participant, a competitive field hockey player and former cyclist, visited our laboratory at 2 weeks of gestation (baseline) and postpartum pre‐, mid‐ and post‐intervention (PPpre, PPmid and PPpost). Delivery was uncomplicated and she felt ready to start the SIT programme 5 weeks postpartum. Inert gas rebreathing was used to measure peak exercise (peak); was measured with a metabolic cart; and postpartum haematological values were measured with carbon monoxide rebreathing. The 18 SIT sessions progressed from four to eight sprints at 130% of peak power output. peak increased from baseline at all postpartum time points (baseline 16.2 vs. 17.5, 16.8 and 17.2 L/min at PPpre, PPmid and PPpost, respectively). Relative remained below baseline values at all postpartum measurements (baseline 44.9 vs. 41.0, 42.3 and 42.5 mL/kg/min at PPpre, PPmid and PPpost, respectively) whereas absolute rapidly reached baseline values postpartum (baseline 3.19 vs. 3.12, 3.23 and 3.18 L/min at PPpre, PPmid and PPpost, respectively). Postpartum BV (5257, 4271 and 5214 mL at PPpre, PPmid and PPpost, respectively) and Hbmass (654, 525 and 641 g at PPpre, PPmid and PPpost, respectively) were similar between PPpre and PPpost but decreased alongside peak at PPmid. Peak power was returned to pre‐pregnancy values by intervention end (302 vs. 303 W, baseline vs. PPpost). These findings show that SIT undertaken early postpartum defends the elevated peak of pregnancy and rapidly returns absolute and peak power to baseline levels.
Changes in protein fluxes and gene expression in non‐injured muscle tissue distant from an acute myotoxic injury in male mice
Authors: Bizieff Alec , Cheng Maggie , Chang Kelvin , Mohammed Hussein , Ziari Naveed , Nyangau Edna , Fitch Mark , Hellerstein Marc K. 
Published: July 2024

AbstractThe response to acute myotoxic injury requires stimulation of local repair mechanisms in the damaged tissue. However, satellite cells in muscle distant from acute injury have been reported to enter a functional state between quiescence and active proliferation. Here, we asked whether protein flux rates are altered in muscle distant from acute local myotoxic injury and how they compare to changes in gene expression from the same tissue. Broad and significant alterations in protein turnover were observed across the proteome in the limb contralateral to injury during the first 10 days after. Interestingly, mRNA changes had almost no correlation with directly measured protein turnover rates. In summary, we show consistent and striking changes in protein flux rates in muscle tissue contralateral to myotoxic injury, with no correlation between changes in mRNA levels and protein synthesis rates. This work motivates further investigation of the mechanisms, including potential neurological factors, responsible for this distant effect.
imageKey points
Previous literature demonstrates that stem cells of uninjured muscle respond to local necrotic muscle tissue damage and regeneration.
We show that muscle tissue that was distant from a model of local necrotic damage had functional changes at both the gene expression and the protein turnover level.
However, these changes in distant tissue were more pronounced during the earlier stages of tissue regeneration and did not correlate well with each other.
The results suggest communication between directly injured tissue and non‐affected tissues that are distant from injury, which warrants further investigation into the potential of this mechanism as a proactive measure for tissue regeneration from damage.
Mobile-CRISPRi protocol optimization for
Vibrionaceae
Authors: Geyman Logan J. , Tanner Madeline P. , Rosario-Meléndez Natalia , Peters Jason M. , Mandel Mark J. , van Kessel Julia C. 
Published: July 2024

ABSTRACT

Mobile clustered regularly interspaced palindromic repeats interference (Mobile-CRISPRi) is an established method for bacterial gene expression knockdown. The deactivated Cas9 protein and guide RNA are isopropyl β-D-1-thiogalactopyranoside inducible, and all components are integrated into the chromosome via Tn
7
transposition. Here, we optimized methods specific for applying Mobile-CRISPRi in multiple
Vibrio
species.
Complete genome sequence of a
Marinococcus
sp. PL1-022 isolated from the pink hypersaline Pearse Lakes, Rottnest Island, Western Australia
Authors: Young Crystal E. , Alattas Hussain , Scott Colin , Murphy Daniel V. , Tiwari Ravi , Reeve Wayne G. 
Published: July 2024

ABSTRACT

Marinococcus
sp. PL1-022 was isolated from Pearse Lakes, Western Australia. The sequenced genome consists of a chromosome (3,140,198 bp; 48.2% GC) and two plasmids (58,083 bp and 19,399 bp; 41.4 and 50.7% GC-content, respectively). Isolation of
Marinococcus
sp. PL1-022 adds to the increasing repertoire of culturable extremophiles.
Complete genome sequence of
Idiomarina
sp. PL1-037 isolated from the pink hypersaline Pearse Lakes, Rottnest Island, Western Australia
Authors: Young Crystal E. , Alattas Hussain , Scott Colin , Murphy Daniel V. , Tiwari Ravi , Reeve Wayne G. 
Published: July 2024

ABSTRACT

Idiomarina
sp. PL1-037 was isolated from Pearse Lakes, Rottnest Island, Western Australia. The sequenced completed genome for PL1-037 is composed of a single chromosome (2,804,934  bp) with a GC content of 47.1%. Isolation of
Idiomarina
sp. PL1-037 provides insights about culturable extremophiles from the Pearse lakes microbiome.
Complete genome sequence of
Erwinia amylovora
PBI209 isolated from a necrotic flower of
Pyrus sinkiangensis
in China
Authors: Gao Ya , Song Bo , Wang Meihong , Yang Fenghuan , Yu Chao , Chen Huamin 
Published: July 2024

ABSTRACT

Here, we report the complete genome sequence of
Erwinia amylovora
PBI209 that causes fire blight isolated from a necrotic flower of
Pyrus sinkiangensis
in Xinjiang, China. The genome consists of 3,800,955 bp, with 3,403 protein-coding genes and a guanine-cytosine content of 53.61%.
Draft genome sequence of ectomycorrhizal edible mushroom
Phlebopus portentosus
strain YAF023
Authors: Yang Mei , Yuan Xiaolong , Kong Lingjia , Gao Yuanni , Liu Chengyi , Wang Yi 
Published: July 2024

ABSTRACT

Phlebopus portentosus
is a favorite ectomycorrhizal edible mushroom in tropical China. Here, we present a draft genome sequence of
P. portentosus
strain YAF023. The genome resource will support subsequent research into the relationship between ectomycorrhizal fungi and trees.
Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: does it influence survival?
Authors: Kaplan Z L Rana , van Leeuwen Nikki , van Klaveren David , Visser Otto , Posthuma Eduardus F M , van Lammeren-Venema Danielle , Snijders Tjeerd J F , van Elssen Catharina H M J , van Rhenen Anna , von dem Borne Peter A , Blijlevens Nicole M A , Cornelissen Jan J , Raaijmakers Marc H G P , van de Loosdrecht Arjan A , Huls Gerwin , Lemmens Valery E P P , Lingsma Hester F , Dinmohamed Avinash G 
Published: July 2024

ObjectiveAcute myeloid leukaemia (AML) prognosis is enhanced with intensive remission induction chemotherapy (ICT) in eligible patients. However, ICT eligibility perceptions may differ among healthcare professionals. This nationwide, population-based study aimed to explore regional variation in ICT application and its relation with overall survival (OS).Methods and analysisWe compared nine Dutch regional networks using data from the Netherlands Cancer Registry. Regional variance was assessed for the entire population and age subgroups (ie, ≤60 years and >60 years) using multivariable mixed effects logistic and Cox proportional hazard regression analyses, expressed via median OR (MOR) and median HR (MHR).ResultsIncluding all adult AML patients from 2014 to 2018 (N=4060 patients; 58% males; median age, 70 years), 1761 (43%) received ICT. ICT application varied from 36% to 57% (MOR 1.36 (95% CI 1.11 to 1.58)) across regions, with minor variations for patients aged ≤60 years (MOR 1.16 (95% CI 1.00 to 1.40)) and more extensive differences for those aged >60 years (MOR 1.43 (95% CI 1.16 to 1.63)). Median OS spanned 4.9–8.4 months across regions (MHR 1.11 (95% CI 1.00 to 1.15)), with pronounced differences in older patients (MHR 1.12 (95% CI 1.08 to 1.20)) but negligible differences in the younger group (MHR 1.02 (95% CI 1.00 to 1.14)). Survival differences for the total population and the older patients decreased to respectively, MHR 1.09 (95% CI 1.00 to 1.13) and 1.10 (95% CI 1.04 to 1.18), after additional adjustment for the probability of receiving ICT within a region, indicating approximately 10% unexplained differences.ConclusionRegional disparities in ICT application and survival exist, especially in older AML patients. However, ICT application differences partially explain survival disparities, indicating the need for more standardised ICT eligibility criteria and a better understanding of underlying causes of outcome disparities.
Protocol for a systematic review with prospective individual patient data meta-analysis in EGFR-mutant NSCLC with brain metastases to assess the effect of SRS+osimertinib compared to osimertinib alone: the STARLET Collaboration
Authors: Robledo Kristy P , Lefresne Shilo , Soon Yu Yang , Sahgal Arjun , Pinkham Mark B , Nichol Alan , Soo Ross Andrew , Parmar Ambika , Hegi-Johnson Fiona , Doherty Mark , Solomon Benjamin J , Shultz David B , Tham Ivan WK , Sacher Adrian G , Tey Jeremy , Leong Cheng Nang , Koh Wee Yao , Huang Yiqing , Ang Yvonne Li En , Low Jiali , Yong Clement , Lim Mei Chin , Tan Ai Peng , Lee Chee Khoon , Ho Cheryl 
Published: July 2024

BackgroundPatients with advanced non-small-cell lung cancer (NSCLC) with activating mutations in the epidermal growth factor receptor (EGFR) gene are a heterogeneous population who often develop brain metastases (BM). The optimal management of patients with asymptomatic brain metastases is unclear given the activity of newer-generation targeted therapies in the central nervous system. We present a protocol for an individual patient data (IPD) prospective meta-analysis to evaluate whether the addition of stereotactic radiosurgery (SRS) before osimertinib treatment will lead to better control of intracranial metastatic disease. This is a clinically relevant question that will inform practice.MethodsRandomised controlled trials will be eligible if they include participants with BM arising fromEGFR-mutant NSCLC and suitable to receive osimertinib both in the first-line and second-line settings (P); comparisons of SRS followed by osimertinib versus osimertinib alone (I, C) and intracranial disease control included as an endpoint (O). Systematic searches of Medline (Ovid), Embase (Ovid), Cochrane Central Register of Controlled Trials (CENTRAL), CINAHL (EBSCO), PsychInfo, ClinicalTrials.gov and the WHO’s International Clinical Trials Registry Platform’s Search Portal will be undertaken. An IPD meta-analysis will be performed using methodologies recommended by the Cochrane Collaboration. The primary outcome is intracranial progression-free survival, as determined by response assessment in neuro-oncology-BM criteria. Secondary outcomes include overall survival, time to whole brain radiotherapy, quality of life, and adverse events of special interest. Effect differences will be explored among prespecified subgroups.Ethics and disseminationApproved by each trial’s ethics committee. Results will be relevant to clinicians, researchers, policymakers and patients, and will be disseminated via publications, presentations and media releases.Prospero registrationCRD42022330532.
Effect of occupational stress and resilience on insomnia among nurses during COVID-19 in China: a structural equation modelling analysis
Authors: Cao Qiyuan , Wu Huiyi , Tang Xiumei , Zhang Qin , Zhang Yang 
Published: July 2024

ObjectivesTo explore the effects of occupational stress and resilience on insomnia among Chinese nurses during the COVID-19 pandemic.Design, settings and participantsA quantitative description study. The data were collected via a cross-sectional survey. A total of 725 front-line nurses at three tertiary hospitals in western China were included from December 2022 to January 2023. The Connor-Davidson Resilience Scale, Job Content Questionnaire, and Athens Insomnia Scale were used to collect data from a self-reported online questionnaire.Outcome measuresThe outcome variable was insomnia, and structural equation modelling was used to assess the associations among resilience, occupational stress and insomnia.ResultsThe prevalence of insomnia among the participants was 58.76%. The structural equation model showed that resilience had a negative direct effect on insomnia and occupational stress, and occupational stress had a positive direct effect on insomnia. Involvement in COVID-19-related work has a positive effect on insomnia through occupational stress. In contrast, higher education levels improved insomnia through increased resilience.ConclusionA significantly higher prevalence of insomnia has been observed among Chinese nurses during the COVID-19 pandemic. Our study suggests that better resilience may improve insomnia by relieving occupational stress, and implementing measures to promote resilience is essential to reduce occupational stress in nurses and improve their sleep quality.
Vascular access specialist teams versus standard practice for catheter insertion and prevention of failure: a systematic review
Authors: Fernandez-Fernandez Ismael , Parra-García Gaizka , Blanco-Mavillard Ian , Carr Peter , Santos-Costa Paulo , Rodríguez-Calero Miguel Ángel 
Published: July 2024

ObjectiveBillions of vascular access devices (VADs) are inserted annually for intravenous therapy worldwide. However, their use is not without challenges. Facilitating the process and enhancing results, hospital authorities have created vascular access specialist teams (VASTs) with advanced competencies in the evaluation, insertion, care and management of VADs. The objective is to compare the effectiveness of VASTs versus standard practice regarding cannulation success and vascular access maintenance in hospitalised adults.DesignSystematic review, using the Mixed Methods Appraisal Tool.Data sourcesWe conducted a structured data search on Cochrane Library, MEDLINE, Web of Science, Scopus and EBSCOhost up to 31 May 2023. We did not impose a time limit regarding the date of publication.Eligibility criteriaStudies were eligible for inclusion in the review if they were randomised and non-randomised trials and observational studies.Data extraction and synthesisWe included studies that described or evaluated the activity of VASTs compared with clinical practitioners. The outcomes analysed were the success of the cannulation and the incidence of associated adverse effects.ResultsThe search strategy produced 3053 papers published between 1984 and 2020, from which 12 were selected for analysis. VASTs are heterogeneously described among these studies, which mainly focus on insertions, frequently for patients with difficult intravenous access. Some patients presented with specific needs or requirement for specific insertion technique or catheter type. Compared with usual practice, these studies indicate that the involvement of a VAST is associated with a higher effectiveness in terms of first attempt insertions and insertion success rates, and a reduction in catheter-associated adverse events. However, meta-analyses confirming this trend are not currently possible.ConclusionsIt seems apparent that VASTS contribute to improving the health of patients during the administration of intravenous. VASTs seem to increase the effectiveness of VAD insertion and care and reduce complications.PROSPERO registration numberCRD42021231259.
Microbial keratitis in the subtropical region of Korea: a comprehensive 12-year retrospective review at a single referral center
Authors: Ji Man , Park Joong Hyun , Ha Ahnul , Jeong Jinho 
Published: July 2024

ObjectivesTo investigate the epidemiological characteristics and clinical outcomes of culture-proven bacterial and fungal keratitis at a single tertiary referral centre on Jeju Island, South Korea.DesignA retrospective study design.SettingData from a solitary referral centre on Jeju Island spanning January 2011 to December 2022.ParticipantsAmong the 245 patients clinically diagnosed with infectious microbial keratitis, 110 individuals had culture-positive results.Primary and secondary outcome measuresThe primary outcome was the identification of causative microbial profiles and epidemiological characteristics, while the secondary outcome was the correlation of these factors with treatment outcomes.ResultsOf 245 patients, 110 (44.9%) had culture-positive infectious keratitis, showing 69 bacterial, 32 fungal, 4 superimposed bacterial and 5 cases with coinfection by bacteria and fungus. The most common pathogen wasPseudomonasspecies in 14.4% of the bacterial keratitis cases, followed byStaphylococcus epidermidis(9%),Staphylococcus aureus(8%) and Moraxella species (7%). The total treatment success rate for bacterial keratitis was 67.5%. The frequency of methicillin-resistantStaphylococcuson Jeju Island did increase during the study period. Fusarium species had the highest incidence at 22.2%, followed byCandida(16.7%) andColletotrichumspecies (11.1%). 56.7% of fungal keratitis patients were successfully treated. An initial large corneal lesion (>3 mm) showed a statistically significant association with treatment failure.ConclusionThe incidence ofMoraxellaandColletotrichumspecies in our study was higher than that reported in other districts with different climates and environments. The results reported here reflect the unique environmental features of Jeju Island, characterised by high humidity and temperatures.