bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of the Application Procedure on The Bond Strength of Universal Adhesive in Restoration Repair
Authors: Tonga Gülşah , Hatirli Hüseyin , Keçeci Fatma , Gül Beyza 
Published: July 2024

Objective: This study aimed to evaluate the effect of reduced application time on the bond strength of a universal adhesive used for the repair of hybrid ceramic and composite resin restorations.
Methods: In the study, a total of 48 rectangular prisms of sizes 7×6×2 mm hybrid ceramic (Vita Enamic, Zahnfabrik, Germany) and composite resin (Solare X, GC, Japan) specimens were prepared. All samples were aged with 5000 thermal cycles. Then, the upper surfaces of the samples were roughened with a diamond fissure bur (10–36µ, 852 FG Meisinger; Hager &amp; Meisinger GmbH, Germany) with 5 strokes under water cooling. The samples were divided into 2 subgroups according to the different application times of the adhesive system (G-Premio Bond, GC, Japan) (n=12). Then, composite resin (Solare X, GC) was placed using plastic cylinder molds with 3 mm inner diameter and height and cured with light for 20 seconds. All samples were thermal aged and then a shear bond strength test was conducted. The data were analyzed with Two-way ANOVA and post-hoc Tukey HSD tests (p˂0,05).
Results: Two-way ANOVA revealed that the repair bond strength of the 10 seconds of waiting was significantly higher than the quick application for both hybrid ceramic and composite resin (p˂0,05). It was determined that there was no significant difference between hybrid ceramic and composite resin in the both quick application group and 10 seconds waiting group (p˃0,05).
Conclusion: Quick application procedure showed lower shear bond strength than 10 seconds waiting group for the repair of both composite resin and hybrid ceramic (p&lt;0,05).
Keywords:	Quick application, Application time, Universal adhesive, restoration repair..
Debris Avalanches in the Northern California Coast Range Triggered by Plate-Boundary Earthquakes
Authors: Pearl Jessie K. , Kelsey Harvey M. , Angster Stephen , Caldwell Dylan , Pryor Ian , Sherrod Brian L. 
Published: July 2024

ABSTRACT
Determining the timing and cause for ancient hillslope failures is challenging in the western United States, yet it is critical because it can inform ground-motion estimates for large-to-great earthquakes on plate-boundary faults. We identify two preinstumental debris avalanches (3×106 and 4.28×106  m3) in the Coast Ranges of northern California. These debris avalanches are well suited for studying the timing (to the exact year) and trigger, as the densely forested landscape enables effective use of dendrochronology and high-resolution radiocarbon to pinpoint the time of failure, and the legacy of landslide studies in the region provides context for evaluating a seismic trigger as the most likely triggering mechanism. Neither of the debris avalanches was triggered by the largest precipitation event of the instrumental record in 1964 C.E., and the two debris avalanche sites are physiographically suited to experience topographic amplification of seismic shaking. Through a suite of geologic and dendrochronologic evidence, we establish the likely time of failure of the two debris avalanches as 1906 C.E. and 933 C.E. The failure of the younger landslide coincides with the 1906 C.E. San Francisco earthquake on the Pacific/North American plate boundary, whereas the older landslide dates to 933 C.E., within the broad age range (850–966 C.E.) of a likely megathrust earthquake on the Cascadia subduction zone as recorded in coastal marshes in Humboldt Bay, California. If the older landslide was triggered by a subduction earthquake, then the precise age of the 933 C.E. debris avalanche would trim the uncertainty on a Cascadia subduction zone event from 116 yr to 1 yr. Utilizing debris avalanche records from sites suitable to record seismic shaking improves understanding of plate-boundary earthquake timing and extent of shaking.
Teneligliptin hydrobromide hydrate mouth dissolving strip: Formulation and evaluation
Authors: Attar S.M. , Ghurghure S.M. , Sumit  
Published: July 2024

Oral route is considered as one of the most convenient route for administration of various pharmaceutical dosage form like tablet, capsule, syrup, suspension and emulsion. Fast Dissolving Drug Delivery systems have developed various fast disintegrating preparations like Oral disintegrating film, ODF. Oral disintegrating film is the solid oral drug delivery system, in which water soluble polymer involve to disintegrate film into mouth fastly. Oral disintegrating film is superior as compare to orally disintegrating tablet as the cost of production is low. The present research was undertaken to develop oral disintegrating film of tteneligliptin hydrobromide hydrate to have rapid onset of action. of tteneligliptin hydrobromide hydrate which is an anti-diabetic. The mechanism action of Teneligliptin is to increase incretin levels (GLP-1 and GIP), which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels.The concept of formulating fast disintegrating film Teneligliptin containing offers a suitable and practical approach in serving desired objective of faster disintegration and dissolution characteristics with increased bioavailability. ODF of Teneligliptin were prepared by solvent casting method and evaluated physicochemical parameters like thickness, weight variation, moisture content, folding endurance, drug content, etc. All the formulations of Teneligliptin ODF displayed optimum folding endurance, which indicates the formulation prepared can withstand handling and transportation. From the results obtained, it was concluded that the formulation of oral disintegrating film has better physical chemical properties with good disintegration property.
The Relationship between the Lifestyle of the Allogeneic Stem Cell Donors and the Number of Donated CD34+ and CD3+ Cells
Authors: Sayadi Leila , Mohammadi Saeed , Aminian Parivash 
Published: July 2024

Background: Hematopoietic stem cell transplantation (HSCT) is considered as the last treatment option in many life-threatening diseases. The number of donated cells can affect transplantation success. This study attempted to investigate the relationship between the health-promoting lifestyle of allogeneic stem cell donors and the number of donated CD34+ and CD3+ cells.
Materials and Methods: The study was a descriptive correlational study in which 100 peripheral blood stem cells donors participated. A demographic form and health-promoting lifestyle profile-II questionnaire were distributed to participants, and then cell separation was started. Afterward, the results of CD34 + and CD3 + cell counts, as well as other clinical parameters of the participants, were recorded. The collected data were analyzed by descriptive and analytical statistical methods.
Results: The results showed that the mean total health-promoting lifestyle profile score for hematopoietic stem cell donors was 2.876±0.461. There was no significant relationship between the health- promoting lifestyle score and the number of CD34+, CD3+ cells and CD3+/CD34+ ratio. A positive and significant correlation was found between the weight of the donors and the number of CD34+ (P < 0.001) and CD3+ cells (P = 0.001). The number of CD34+ cells was significantly different between women and men (P = 0.009).
Conclusion: Lifestyle had no significant effect on the number of CD3+/CD34+ cells. Moreover, the number of CD34+ cells was significantly higher in men, so males should be preferentially recruited as donors for the HSCT procedure.
Comparison of Cyclophosphamide-Based Graft Versus Host Disease Prophylaxis after “Allogeneic Stem Cell Transplantation from 9/10HLA Matched Unrelated Donor’’ with Standard Graft Versus Host Disease Prophylaxis after “10/10HLA Matched Relative Donor’’
Authors: Yıldırım Murat , Sayın Selim , Cömert Melda , Yılmaz Esra Şafak , Avcu Ferit , Ural Ali Uğur , Aylı Meltem 
Published: July 2024

Background: Graft Versus Host Disease (GvHD), which can be observed at a rate of 30-80% after allogeneic stem cell transplantation (ASCT) is an important complication that adversely affects the survival and quality of the life of patients. Posttransplant cyclophosphamide (PTCy) effectively prevents GvHD after HLA-haploidentical ASCT. In our study, the use of PTCy in 1-antigen HLA-mismatched unrelated donor (9/10MMUD) ASCT was compared with standard GvHD prophylaxis in HLA-identical related donor (MRD) ASCT.
Materials and Methods: We conducted a retrospective study of the comparison of 42 patients with 9/10 MMUD ASCT receiving PTCy+Methotrexate (MTX)+Calcineurin Inhibitor (CNI) and 37 patients with HLA-identical MRD who received MTX+CNI in 3 bone marrow transplantation centers.
Results: Cumulative incidences of grade I-II (64.6% vs 45.4%, p=0.187) or grade III to IV acute GvHD (35.4% vs54.6%, p=0.187) and chronic GvHD (11.9% vs 29.7%, p=0.096) were similar in the PTCy group and control group. No statistically significant differences were observed between PTCy and the control group in overall survival rate (52.4% vs 62.2%, p=0.381), progression-free survival (1483.97 vs 1200.70 days, p=0.502), relapsed-related mortality rate (21.4% vs 16.2%, p=0.556) and treatment-related mortality rate (16.7% vs 21.6%, p=0.575).
Conclusion: With the addition of PTCy to standard GvHD prophylaxis in 9/10MMUD ASCT, the risk of GvHD due to incompatibility and unrelated transplantation is eliminated, and transplantation success is achieved with MRD ASCT. PTCy-based prophylaxis is an effective and safe strategy to prevent GvHD in 9/10 MMUD ASCT without increasing the risk of relapse and treatment-related mortality.
Identification of Technosols formed from industrial dust in the area of Yazd city (Central Iran) by ground-based radiometry
Authors: Akhavan Ghalibaf M. , Masoodi S. , Shirazi-Chalashtary M. , Delavarkhalafi A. 
Published: July 2024

Intensive industrial development in the form of metallurgical plants and quarries for mining of mineral resources in the vicinity of the city of Yazd resulted in significant dustiness of the ground layer of atmosphere and accumulation of industrial dust on the soil surface. At the locations of alloy steel production facilities, dust composition was dominated by particulate matter less than 1 μm (PM1), while near sand quarries, dust particles less than 10 μm (PM10) were predominant. The dust from these sources also differs in chemical composition (iron/silicon content ratio, pH). Registration with a pyranometer with a dark green filter with transmittance at a wavelength of 550 nanometers with a time interval of 20 seconds at a speed of 30 km/h during the movement along the specified routes allowed authors to identify zones with a stable increased content of particles of different sizes in the near-surface atmosphere. Sampling soil pits in these zones confirmed the presence on their surface of layers of dust deposits with a thickness of more than 5 cm, which allows them to be attributed to Technosols in accordance with the WRB soil classification. The soil map of the research area was compiled at a scale of 1 : 25 000 with the reflection of Technosols participation in the soil patterns. According to the map, more than three quarters of the study area are soil complexes including Technosols. Arid climatic conditions of the region lead to the accumulation of dust on the soil surface, which are practically not transformed and not removed from the soil, which results in their degradation and deterioration of the environmental conditions. Dust accumulation on the soil surface affects the state of vegetation cover of the region, which serves as a basis for indirect satellite indication of dusting zones. The method of revealing the dust layer on the soil surface based on the assessment of dustiness of the near-surface atmosphere using pyranometer can serve as a good complement to remote sensing methods.
Development of Interactive Multimedia Based on Android Integrated Problem Based Learning (PBL) to Improve Students’s Mastery of Concepts
Authors: Bintarti  , Roza Linda  , Rasmiwetti  
Published: July 2024

The results of the pre-research concept mastery test showed students' low mastery of redox and electrochemical concepts. The aim of this research is to produce an Android-based interactive multimedia product integrated with PBL that is valid, practical and effective in the form of an APK. The research method is Development Research referring to the ADDIE development procedure. The research was conducted in the odd semester of 2022/2023. The research sample are 70 students of class XII MIPA SMA N 10 Pekanbaru. Data was collected through multiple choice tests, essays, questionnaires. The developed product was validated by 3 material experts, and 3 media experts. The practicality tes was carried out by 4 chemistry teachers, 11 students in the one to one and small group stages. The implementation test was carried out at SMA Negeri 10 Pekanbaru. The average validation results by material experts were 94.8% with very valid criteria and the average validation results by media experts were 95.8% (very valid). Practicality results for 4 chemistry teachers, it was 91.3 in the very practical category and 88.8% for 11 students in the very practical category. The n-gain test results showed an increase in concept mastery in the experimental class, namely 0.7 in the medium category and the control class with an n gain value of 0.3 (low). Based on the research results, it was concluded that the product that had been developed could increase students' mastery of concepts.
Prospective primary mathematics teachers’ attitude towards statistics
Authors: Dahlan Taufiqulloh , Lumbantoruan Jitu Halomoan 
Published: July 2024

[English]: This study aimed to assess attitudes of prospective primary mathematics teachers (PPTs) toward statistics and how these attitudes are influenced by gender. It adopted Attitudes Towards Statistics Survey (SATS-36) and involved 455 PPTs from 9 Teachers Training Institutions (TTI). Exploratory factor analysis (EFA) was performed because the model fit for confirmatory factor analysis (CFA) failed to yield good indices of reliability and validity. The validated model only contains 27 items in four factors that assess attitudes including competence, values, difficulties, and interests. The prospective teachers’ attitudes toward statistics and the impact of gender were then evaluated using a modified four-factor model. The finding shows that PPTs have a positive attitude toward statistics. In specific, the female participants tend to have a more positive attitude toward statistics than the male.
[Bahasa]: Penelitian ini bertujuan menilai sikap calon guru matematika sekolah dasar terhadap statistika dan bagaimana sikap tersebut dipengaruhi oleh jenis kelamin. Penelitian ini mengadopsi Survei Sikap terhadap Statistik (SATS-36) dan melibatkan 455 calon guru dari 9 Lembaga Pendidik Tenaga Kependidikan. Analisis faktor eksploratori (EFA) dilakukan karena model yang cocok untuk analisis faktor konfirmatori (CFA) gagal menghasilkan indeks yang baik untuk reliabilitas dan validitas. Model yang telah divalidasi hanya memuat 27 item dalam empat faktor untuk menilai sikap yang meliputi kompetensi, nilai, kesulitan, dan minat. Sikap calon guru terhadap statistik dan dampak gender kemudian dievaluasi menggunakan model empat faktor yang dimodifikasi. Hasil penelitian menunjukkan bahwa calon guru mempunyai sikap positif terhadap statistik. Secara spesifik, calon guru perempuan lebih mempunyai sikap positif terhadap statistik daripada calon guru laki-laki.
Can Electroencephalography-Based Neurofeedback Treat Post-Traumatic Stress Disorder? A Meta-Analysis Study
Authors: Matsuyanagi Kana 
Published: July 2024

Abstract

Objective: Post-traumatic stress disorder (PTSD) remains a significant clinical challenge with limited treatment options. Although electroencephalogram (EEG) neurofeedback has garnered attention as a prospective treatment modality for PTSD, no comprehensive meta-analysis has been conducted to assess its efficacy and compare different treatment protocols. This study aims to provide a multi-variable meta-regression analysis of EEG neurofeedback's impact on PTSD symptoms, while also assessing variables that may influence treatment outcomes.
Methods: A systematic review was performed to identify controlled studies exploring for the efficacy of EEG neurofeedback on PTSD. The overall effectiveness was evaluated through meta-analysis, and a multi-variable meta-regression was employed to discern fact0rs affecting the EEG neurofeedback efficacy.
Results: EEG neurofeedback yielded a statistically significant reduction in PTSD symptoms immediately post-intervention, with sustained effects at one and three months follow-up. A sub-analysis of sham-controlled studies confirmed that outcomes were not driven by placebo effects. Our findings also identified the target frequency and region, as well as feedback modality, as significant factors for treatment success. In contrast, variables related to treatment duration were not found to be significant moderators, suggesting cost-effectiveness.
Conclusions: EEG neurofeedback emerges as a promising and cost-effective treatment modality for PTSD with the potential for long-term benefits. Our findings challenge commonly utilized protocols and advocate for further research into alternative methodologies to improve treatment efficacy.
Comprehensive characterization of tumor innervation in colorectal cancer
Authors: HUO RX , Huo Ruixue , Wang Hao , He Kexin , Gao Yuan , He Wei , Li Weihan , Zhang Shan , Jiang Shu-Heng , Yu Minhao , Xue Junli 
Published: July 2024

Abstract

Purpose
Complex innervation occurs at colorectal cancer (CRC) sites, and these nerves play a certain role in the occurrence and development of tumors. This study aimed to reveal the morphological changes in the nervous system in CRC and the corresponding clinical relevance of these changes.
Methods
The neurofilament-specific marker NF-L and glial cell-specific marker S100β were used to define infiltrated nerves by immunofluorescence analysis in a CRC cohort (n = 155). Neural density and diameter at off-tumor and on-tumor sites (including core regions and peritumoral regions) were quantified.
Results
In CRC, tumor cells frequently erode surrounding nerves, causing interruption of the submucosal and muscular plexus, as well as deformation of nerve fibers. Compared to off-tumor sites, on-tumor sites showed decreased nerve density and increased nerve diameter. At on-tumor sites, the nerve density at the core region was significantly lower than the peritumoral nerve density. According to the subgroup analysis, KRAS mutations were associated with decreased nerve density in the core region. The presence of perineural invasion (PNI) was associated with larger nerve diameters and greater nerve densities in the core region. As the tumor size increased, the nerve density decreased in both the core and peritumoral regions. With increasing T stage (infiltration depth) from T1 to T3, the nerve diameter increased in both the core and peritumoral regions, while the opposite trend was found for the peritumoral nerve density. Similar results were also found for stages I to III (AJCC stage). In patients with metastasis (M1 or stage IV), the nerve density increased in the core region.
Conclusion
Our study revealed the landscape of innervation in CRC and its clinical associations, thus providing a reference for subsequent mechanistic research on nerve-cancer interactions and the development of nerve-based antitumor drugs.
Clinical and radiological pattern of olaparib- induced interstitial lung disease
Authors: Brudon Alexandre , Fournier Dorine , Selle Frédéric , Seront Emmanuel , Conforti Rosa , Veyrac Gwenaëlle , Gouraud Aurore , Lebrun-Vignes Bénédicte , Khalil Antoine , Zalcman Gérard , Gounant Valérie 
Published: July 2024

Abstract

Background:PARP inhibitors (PARPi) are used in the treatment of ovarian, breast, pancreatic, and prostate cancers. Pneumonitis has been identified as a potential side effect, with a higher meta-analysis-assessed risk for olaparib versus other PARPi. Olaparib-induced interstitial lung disease (O-ILD) was first described within the Japanese population, with few information available for Caucasian patients.
Methods: We performed a retrospective study by pooling data from the French and Belgian pharmacovigilance databases from 2018 to 2022. Patients with O-ILD were included following a central review by: 1) pharmacologists using the French drug causality assessment method; 2) senior pneumologists or radiologists, using the Fleischner Society’s recommendations.
Results:Five patients were identified and analysed. All were females, with ovarian or breast cancer. Median age at O-ILD diagnosis was 71 (38-72) years old, with no smoking history. Median delay between treatment initiation and symptom occurrence was 12 (6-33) weeks. Pneumonitis severity assessed using the Common Terminology Criteria for Adverse Events V5 was Grade 3 (n=4) or 2 (n=1). CT-scan review (n=3) described hypersensitivity pneumonitis as a common pattern. Bronchioalveolar lavage (n=4) revealed lymphocytic alveolitis. Treatments relied on olaparib discontinuation (n=5) and glucocorticoid intake (n=4), with no fatal issue. Safe re-challenge with PARPi occurred in two patients. Forty additional O-ILD cases were identified in the WHO VigiBase database, including one fatal case.
Conclusions:PARPi-ILD is a rare but potentially life-threatening disease, presenting as a hypersensitivity pneumonitis pattern within 3 months of PARPi initiation. Treatment primarily relies on medication discontinuation. Re-challenging with another PARPi could be considered.
Clinical trial number : CEPRO #2023-010
Identifying causal genes in alopecia areata using integrative analysis of differential expression and Mendelian randomization
Authors: Zhao Huixia , He Xiaoyuan , Zhang Yuting , Ning Xiaoli , Hu Zhian , Zhan Zhenrun , Gao Chong , Luo Jing 
Published: July 2024

Abstract

Background
Compared with sporadic patients with Alopecia areata (AA), the familial cases have a poorer prognosis. At present, the genetic basis of AA still needs further study to improve treatment and prognosis. The aim of this study is to identify the causal genes related to AA.
Methods
We first used bioinformatics analysis to screen the differentially expressed genes (DEGs) related to AA, and then analyzed large-scale eQTL data and AA GWAS summary data using Mendelian randomization (MR). The enrichment analysis of causal gene functions and pathways as well as immune cell infiltration analysis were also performed, and finally the screened causal genes were analyzed and validated in the experimental group of AA and the normal control group.
Results
Differential expressed gene (DEG) analysis identified 429 up-regulated and 423 down-regulated genes. Among DEGs, MR screened out four intersecting genes, GIMAP6 and AA (IVW OR: 1.868; 95% CI: 1.175–2.970, p = 0.008), ALOX15 and AA (IVW OR: 1.616; 95% CI: 1.167–2.239, p = 0.004), GALNT6 and AA (IVW OR: 0.710; 95% CI: 0.533–0.945, p = 0.019), HEG1 and AA (IVW OR: 0.648; 95% CI: 0.431–0.975, p = 0.037). Indicating that all four intersecting genes have a causal relationship with AA, they are the four causal genes most related to AA. Among them, genes GIMAP6 and ALOX15 are risk factors for AA, while genes GALNT6 and HEG1 are protective factors for AA. Finally, validation analysis was conducted on the four causal genes between the AA experimental group and the normal control group, and significant differences were found in the GALNT6 and HEG1 genes in the validation group.
Conclusion
In this study, we identified four causal genes for AA and found that genes GIMAP6 and ALOX15 are risk factors for AA and genes GALNT6 and HEG1 are protective factors for AA. Our data analysis showed significant differences between the GALNT6 and HEG1 genes in the validation group. This study will provide new research directions for the pathogenesis and clinical diagnosis and treatment of AA.