bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forward‐Looking Monetary Policy Rules and Option‐Implied Interest Rate Expectations
Authors: Sihvonen Jukka , Vähämaa Sami 
Published: February 2013

AbstractThis paper examines the association between option‐implied interest rate distributions and macroeconomic expectations in the context of a forward‐looking monetary policy rule. We presume that market participants view the policy rule as a guide to the path of future policy rates and price interest rate options in accordance with the policy rule fundamentals. Using data from the UK, we confirm that Libor expectations implied by option prices are consistent with the policy rule variables. The results demonstrate that changes in the distributional form of Libor expectations are strongly associated with changes in the expected inflation and output gaps and financial uncertainty. © 2013 Wiley Periodicals, Inc. Jrl Fut Mark 34:346–373, 2014
Closing Call Auctions at the Index Futures Market
Authors: Hagströmer Björn , Nordén Lars 
Published: February 2013

AbstractWe investigate the effects from the introduction of a closing call auction (CCA) at the index futures market. Limit order book models, where trader patience determines trading strategies, predict that a CCA increases trader patience and, hence, improves closing price accuracy and end‐of‐day liquidity. We find that the introduction leads to increased trader patience, improved futures closing price accuracy, unaffected tightness and resiliency, and decreased depth. Decreased depth is likely due to less order fishing activity. With the CCA, opportunistic patient traders' posting of limit orders deep in the order book, to profit from impatient traders, is no longer feasible. © 2013 Wiley Periodicals, Inc. Jrl Fut Mark 34:299–319, 2014
Information content of aerosol retrievals in the sunglint region
Authors: Ottaviani M. , Knobelspiesse K. , Cairns B. , Mishchenko M. 
Published: February 2013

AbstractWe exploit quantitative metrics to investigate the information content in retrievals of atmospheric aerosol parameters (with a focus on single‐scattering albedo), contained in multi‐angle and multi‐spectral measurements with sufficient dynamical range in the sunglint region. The simulations are performed for two classes of maritime aerosols with optical and microphysical properties compiled from measurements of the Aerosol Robotic Network. The information content is assessed using the inverse formalism and is compared to that deriving from observations not affected by sunglint. We find that there indeed is additional information in measurements containing sunglint, not just for single‐scattering albedo, but also for aerosol optical thickness and the complex refractive index of the fine aerosol size mode, although the amount of additional information varies with aerosol type.
Absolute concentrations of highly vibrationally excited OH(υ = 9 + 8) in the mesopause region derived from the TIMED/SABER instrument
Authors: Mast Jeffrey , Mlynczak Martin G. , Hunt Linda A. , Marshall B. Thomas , Mertens Christoper J. , Russell James M. , Thompson R. Earl , Gordley Larry L. 
Published: February 2013

AbstractAbsolute concentrations (cm–3) of highly vibrationally excited hydroxyl (OH) are derived from measurements of the volume emission rate of the υ = 9 + 8 states of the OH radical made by the SABER instrument on the TIMED satellite. SABER has exceptionally sensitive measurement precision that corresponds to an ability to detect changes in volume emission rate on the order of ~5 excited OH molecules per cm3. Peak zonal annual mean concentrations observed by SABER exceed 1000 cm–3 at night and 225 cm–3 during the day. Measurements since 2002 show an apparent altitude‐dependent variation of the night OH(υ = 9 + 8) concentrations with the 11 year solar cycle, with concentrations decreasing below ~ 95 km from 2002 to 2008. These observations provide a global database for evaluating photochemical model computations of OH abundance, reaction kinetics, and rates and mechanisms responsible for maintaining vibrationally excited OH in the mesopause region.
A comparison of surface and subsurface controls on summer temperature in a headwater stream
Authors: MacDonald Ryan J. , Boon Sarah , Byrne James M. , Silins Uldis 
Published: February 2013

AbstractThis study compared summer stream temperature between two years in the Star Creek catchment, Alberta, a headwater basin on the eastern slopes of the Canadian Rocky Mountains. Star Creek is a subsurface water dominated stream, which represents important habitat for native salmonid species. Hydrometeorological data from May to September of 2010 and 2011 accompanied by stream energy budget calculations were used to describe the drivers of stream temperature in this small forested stream. Mean, maximum, and minimum weekly stream temperatures were lower from May to August and higher in September 2011 compared to 2010. Weekly range in stream temperature was also different between years with a higher range in 2010. Inter‐annual stream temperature variation was attributed discharge differences between years, shown to be primarily governed by catchment‐scale moisture conditions. This study demonstrates that both meteorological and hydrological processes must be considered in order to understand stream temperature response to changing environmental conditions in mountainous regions. Copyright © 2013 John Wiley & Sons, Ltd.
A Mouse Model for Human Osteogenesis Imperfecta Type VI
Authors: Bogan Rosalind , Riddle Ryan C , Li Zhu , Kumar Sarvesh , Nandal Anjali , Faugere Marie-Claude , Boskey Adele , Crawford Susan E , Clemens Thomas L 
Published: February 2013

ABSTRACT

Osteogenesis imperfecta type VI (OI type VI) has recently be linked to a mutation in the SERPINF1 gene, which encodes pigment epithelium-derived factor (PEDF), a ubiquitously expressed protein originally described for its neurotrophic and antiangiogenic properties. In this study, we characterized the skeletal phenotype of a mouse with targeted disruption of Pedf. In normal mouse bone, Pedf was localized to osteoblasts and osteocytes. Micro–computed tomography (µCT) and quantitative bone histomorphometry in femurs of mature Pedf null mutants revealed reduced trabecular bone volume and the accumulation of unmineralized bone matrix. Fourier transform infrared microscopy (FTIR) indicated an increased mineral:matrix ratio in mutant bones, which were more brittle than controls. In vitro, osteoblasts from Pedf null mice exhibited enhanced mineral deposition as assessed by Alizarin Red staining and an increased mineral:matrix determined by FTIR analysis of calcified nodules. The findings in this mouse model mimic the principal structural and biochemical features of bone observed in humans with OI type VI and consequently provide a useful model with which to further investigate the role of PEDF in this bone disorder.
SEM study of semi‐oriented tube microstructures of Serpulidae (Polychaeta, Annelida): Implications for the evolution of complex oriented microstructures
Authors: Vinn Olev 
Published: February 2013

ABSTRACTSemi‐oriented microstructures represent an intermediate state between isotropic and complex oriented microstructures of serpulids. Semi‐oriented microstructures are apparently unique to serpulids, indicating that there may have been unique aspects in the evolution of their biomineralization system. The occurrence of semi‐oriented microstructures in serpulids supports the hypothesis that complex oriented microstructures are derived from isotropic microstructures via evolution of a biochemical crystal orientation control mechanism. Microsc. Res. Tech. 76:453–456, 2013. © 2013 Wiley Periodicals, Inc.
Genetic blockade of insulin‐like growth factor‐1 receptor via recombinant adenovirus in lung cancer can be enhanced by the histone deacetylase inhibitor, vorinostat
Authors: Park Mi‐Young , Kim Dal Rae , Eo Eun Young , Lim Hyo Jeong , Park Jong Sun , Cho Young‐Jae , Yoon Ho‐Il , Lee Jae Ho , Lee Choon‐Taek 
Published: February 2013

AbstractBackgroundMany approaches have been suggested as anti‐tumor therapy for targeting insulin‐like growth factor 1 receptor (IGF‐1R), such as monoclonal antibodies and tyrosine kinase inhibitor. We introduced recombinant adenoviruses expressing antisense, dominant negative or short hairpin RNA to IGF‐1R. Moreover, we demonstrated that histone deacetylase inhibitor (vorinostat) can increase the transduction efficiency of adenoviruses by increasing CAR‐induced transduction and by enhancing the transcription of the adenoviral transgene. In the present study, we showed that the combination of ad‐sh (short hairpin) IGF‐1R with vorinostat leads to a synergistic enhancement of IGF‐1R blockade.MethodsWe measured the change in IGF‐1R upon cotreatment with vorinostat and ad‐shIGF‐1R. Changes in transduction efficiency of ad‐shIGF‐1R were measured by fluorescent microscopy. Changes in apoptotic proportion and cell survival after the cotreatment were measured by the sub‐G1 assay and cell counts. The effect of nuclear factor (NF)‐κB activation was also measured by NF‐κB p65 activation enzyme‐linked immunosorbent assay. Drug interactions were analyzed upon cotreatment with ad‐shIGF‐1R, vorinostat and cisplatin.ResultsCombined treatment of ad‐shIGF‐1R and vorinostat synergistically suppressed the IGF‐1R expression in lung cancer cell lines and also increased the transduction efficiency of ad‐shIGF‐1R. Ad‐shIGF‐1R and vorinostat cotreatment increased apoptotic cell death and synergistically suppressed cell growth compared to ad‐shIGF‐1R or vorinostat treatment alone. Vorinostat suppressed NF‐κB activation, which was activated by ad‐shIGF‐1R. Moreover, triple combination of ad‐shIGF‐1R, vorinostat and cisplatin demonstrated synergistic cytotoxicity on lung cancer cells.ConclusionsVorinostat enhanced the blocking capability of ad‐shIGF‐1R. The combined treatment of vorinostat and ad‐sh‐IGF‐1R appears to have promising potential as a new therapeutic approach for lung cancer. Copyright © 2013 John Wiley & Sons, Ltd.
Linear Balanceable and Subcubic Balanceable Graphs*
Authors: Aboulker Pierre , Radovanović Marko , Trotignon Nicolas , Trunck Théophile , Vušković Kristina 
Published: February 2013

AbstractIn Math Program 55(1992), 129–168, Conforti and Rao conjectured that every balanced bipartite graph contains an edge that is not the unique chord of a cycle. We prove this conjecture for balanced bipartite graphs that do not contain a cycle of length 4 (also known as linear balanced bipartite graphs), and for balanced bipartite graphs whose maximum degree is at most 3. We in fact obtain results for more general classes, namely linear balanceable and subcubic balanceable graphs. Additionally, we prove that cubic balanced graphs contain a pair of twins, a result that was conjectured by Morris, Spiga, and Webb in ( Discrete Math 310(2010), 3228–3235).
Imaging of metals in biological tissue by laser ablation inductively coupled plasma mass spectrometry (LA–ICP–MS): state of the art and future developments
Authors: Sabine Becker J. 
Published: February 2013

Laser ablation inductively coupled plasma mass spectrometry (LA–ICP–MS) is well established as a sensitive trace and ultratrace analytical technique with multielement capability for bioimaging of metals and studying metallomics in biological and medical tissue. Metals and metalloproteins play a key role in the metabolism and formation of metal‐containing deposits in the brain but also in the liver. In various diseases, analysis of metals and metalloproteins is essential for understanding the underlying cellular processes. LA–ICP–MS imaging (LA–ICP–MSI) combined with other complementary imaging techniques is a sophisticated tool for investigating the regional and cellular distribution of metals and related metal‐containing biomolecules. On the basis of successful routine techniques for the elemental bioimaging of cryosections by LA–ICP–MSI with a spatial resolution between 200 and ~10 µm, the further development used online laser microdissection ICP–MSI to study the metal distribution in small biological sample sections (at the cellular level from 10 µm to the submicrometer range).The use of mass spectrometric imaging of metals and also nonmetals is demonstrated on a series of biological specimens. This article discusses the state of the art of bioimaging of metals in thin biological tissue sections by LA–ICP–MSI with spatial resolution at the micrometer scale, future developments and prospects for quantitative imaging techniques of metals in the nanometer range. In addition, combining quantitative elemental imaging by LA/laser microdissection–ICP–MSI with biomolecular imaging by matrix‐assisted laser desorption/ionization–MSI will be challenging for future life science research. Copyright © 2013 John Wiley & Sons, Ltd.
Absorbing boundary conditions for the FD‐TLM method : the perfectly matched layer and the one‐way equation technique
Authors: Attia M. , Ney M. , Aguili T. 
Published: February 2013

SUMMARYThis paper investigates the absorbing boundary conditions for the frequency domain transmission line matrix method. Two approaches are presented, namely the perfectly matched layer (PML) technique and the one‐way wave equation. Concerning the PML technique, two‐dimensional and three‐dimensional transmission line matrix (TLM) nodes, already used in time domain, are exploited in frequency domain where a rigorous formulation of these PML–TLM nodes is presented. In addition, two types of one‐way wave operators are also transposed from time to frequency domain TLM approach: Taylor expansion and Higdon's boundary conditions. The simulation of a wideband matched load WR‐28 rectangular waveguide is presented for validation. Excellent results are obtained with a very thin PML layer. Results concerning one‐way operator techniques also show very good return loss performances. For instance, Higdon's boundary condition was extended beyond third‐order approximation, and a return loss better than 160 dB was obtained. Copyright © 2013 John Wiley & Sons, Ltd.
Decadal variability of droughts and floods in the Yellow River basin during the last five centuries and relations with the North Atlantic SST
Authors: Zhang Jie , Li Dongliang , Li Laurent , Deng Weitao 
Published: February 2013

ABSTRACTDroughts and floods are frequent disasters in the Yellow River basin in northern China. They have a strong impact on agriculture and water resource management. To explore the physical mechanisms of these droughts and floods, influences exerted by the sea surface temperature (SST) anomalies in the mid‐latitude North Atlantic on the wetness and dryness in the Yellow River basin have been investigated. The drought/flood index (DFI), derived from a reconstructed dataset covering the last five centuries, is used. Numerical simulations are conducted with the Community Atmospheric Model version 3.0 (CAM3) to study the influence of various mechanisms. It is found that DFI in the entire Yellow River basin experienced oscillations at about 50–60 years during the past five centuries. Droughts and floods have inconsistent patterns in different areas of the Yellow River. The periodic variation of DFI in Xi'an, a station in a semi‐humid subarea, is in contrast to the North Atlantic SST (10°N–55°N and 70°W–10°W) oscillation in spring and summer; the periodic variation of the Yinchuan DFI in a semi‐arid subarea (the upper reaches of Yellow River) correlates with the North Atlantic SST oscillation variation in spring and summer. The North Atlantic SST is probably one of the key sources of internal variability of the climate system, which results in Rossby wave adjusting. The warm phase of the North Atlantic SST is related to the operation of a Northern Atlantic Oscillation (NAO) like pattern conducive to easterly wind anomalies in northern China and enhances anti‐cyclones around Lake Baikal that leads to less precipitation or more frequent droughts in the semi‐arid subarea in the upper reaches of the Yellow River, but wet conditions in the semi‐humid subarea in the middle reaches, monsoon subarea in the lower reaches and plateau subarea in the upper reaches of the river.
Lateglacial ice dynamics of the Cordilleran Ice Sheet in northern British Columbia and southern Yukon Territory: retreat pattern of the Liard Lobe reconstructed from the glacial landform record
Authors: Margold Martin , Jansson Krister N. , Kleman Johan , Stroeven Arjen P. 
Published: February 2013

AbstractThe Liard Lobe formed a part of the north‐eastern sector of the Cordilleran Ice Sheet and drained ice from accumulation areas in the Selwyn, Pelly, Cassiar and Skeena mountains. This study reconstructs the ice retreat pattern of the Liard Lobe during the last deglaciation from the glacial landform record that comprises glacial lineations and landforms of the meltwater system such as eskers, meltwater channels, perched deltas and outwash fans. The spatial distribution of these landforms defines the successive configurations of the ice sheet during the deglaciation. The Liard Lobe retreated to the west and south‐west across the Hyland Highland from its local Last Glacial Maximum position in the south‐eastern Mackenzie Mountains where it coalesced with the Laurentide Ice Sheet. Retreat across the Liard Lowland is evidenced by large esker complexes that stretch across the Liard Lowland cutting across the contemporary drainage network. Ice margin positions from the late stage of deglaciation are reconstructed locally at the foot of the Cassiar Mountains and further up‐valley in an eastern‐facing valley of the Cassiar Mountains. The presented landform record indicates that the deglaciation of the Liard Lobe was accomplished mainly by active ice retreat and that ice stagnation played a minor role in the deglaciation of this region. Copyright © 2013 John Wiley & Sons, Ltd.
Environmental variability during the Last Interglacial: a new high‐resolution pollen record from Tenaghi Philippon, Greece
Authors: Milner Alice M. , Müller Ulrich C. , Roucoux Katherine H. , Collier Richard E. L. , Pross Jörg , Kalaitzidis Stavros , Christanis Kimon , Tzedakis Polychronis C. 
Published: February 2013

AbstractA new high‐resolution Last Interglacial pollen record from the Tenaghi Philippon peatland, northeast Greece, documents variability in forest composition and cover, which we attribute to changes in temperature and moisture availability. The declining stage of the interglacial was marked by a stepwise decrease in temperate tree populations and culminated in the complete collapse of forest at the onset of the ensuing stadial. The coincidence of the onset of the stepwise declining trend with the increased prominence of North Atlantic ice‐rafting events suggests that ecological thresholds in southern Europe were only crossed once ice rafting events intensified, and implies that changes in North Atlantic ocean circulation were an important contributing factor to the declining temperate forest cover in southern Europe. Our results provide evidence for intra‐interglacial variability in the low mid latitudes and suggest a coupling between the high northern latitudes and the northeast Mediterranean during this interval. Copyright © 2013 John Wiley & Sons, Ltd.
Method for high‐resolution imaging of creatine in vivo using chemical exchange saturation transfer
Authors: Kogan Feliks , Haris Mohammad , Singh Anup , Cai Kejia , Debrosse Catherine , Nanga Ravi Prakash Reddy , Hariharan Hari , Reddy Ravinder 
Published: February 2013

PurposeTo develop a chemical exchange saturation transfer (CEST)‐based technique to measure free creatine (Cr) and to validate the technique by measuring the distribution of Cr in muscle with high spatial resolution before and after exercise.MethodsPhantom studies were performed to determine contributions from other Cr kinase metabolites to the CEST effect from Cr (CrCEST). CEST, T2, magnetization transfer ratio and 31P magnetic resonance spectroscopy acquisitions of the lower leg were performed before and after plantar flexion exercise on a 7T whole‐body magnetic resonance scanner on healthy volunteers.ResultsPhantom studies demonstrated that while Cr exhibited significant CEST effect there were no appreciable contributions from other metabolites. In healthy human subjects, following mild plantar flexion exercise, increases in the CEST effect from Cr were observed, which recovered exponentially back to baseline. This technique exhibited good spatial resolution and was able to differentiate differences in muscle utilization among subjects. The CEST effect from Cr results were compared with 31P magnetic resonance spectroscopy results showing good agreement in the Cr and phosphocreatine recovery kinetics.ConclusionDemonstrated a CEST‐based technique to measure free Cr changes in in vivo muscle. The CEST effect from Cr imaging can spatially map changes in Cr concentration in muscle following mild exercise. This may serve as a tool for the diagnosis and treatment of various disorders affecting muscle. Magn Reson Med 71:164–172, 2014. © 2013 Wiley Periodicals, Inc.
NMR HRMAS spectroscopy of lung biopsy samples: Comparison study between human, pig, rat, and mouse metabolomics
Authors: Benahmed Malika A. , Elbayed Karim , Daubeuf François , Santelmo Nicola , Frossard Nelly , Namer Izzie J. 
Published: February 2013

PurposeUsing the metabolomics by NMR high‐resolution magic angle spinning spectroscopy, we assessed the lung metabolome of various animal species in order to identify the animal model that could be substituted to human lung in studies on fresh lung biopsies.MethodsThe experiments were conducted on intact lung biopsy samples of pig, rat, mouse, and human using a Bruker Advance III 500 spectrometer. Thirty‐five to 39 metabolites were identified and 23 metabolites were quantified. Principal component analysis, partial least‐squares discriminant analysis, and analysis of variance tests were performed in order to compare the metabolic profiles of each animal lung biopsies to those of the human lung.ResultsThe metabolic composition between human and pig lung was similar. However, human lung was distinguishable from mouse and rat regarding: Trimethylamine N‐oxide and betaïne which were present in rodents but not in human lung, carnitine, and glycerophosphocholine which were present in mouse but not in human lung. Conversely, succinic acid was undetected in rat lung. Furthermore, fatty acids concentration was significantly higher in rodent lungs compared to human lung.ConclusionUsing the metabolomics by NMR high‐resolution magic angle spinning spectroscopy on lung biopsy, samples allowed to highlight that pig lung seems to be close to human lung as regarding its metabolite composition with more similarities than dissimilarities. Magn Reson Med 71:35–43, 2014. © 2013 Wiley Periodicals, Inc.
Use of Magnetization Transfer Contrast MRI to Detect Early Molecular Pathology in Alzheimer's Disease
Authors: Pérez‐Torres Carlos J. , Reynolds Julia O. , Pautler Robia G. 
Published: February 2013

PurposeThe purpose of this study was to determine if magnetization transfer contrast (MTC) imaging could be used to detect early macromolecular accumulation in a mouse model of early Alzheimer's disease.MethodsWe obtained MTC images at 9.4 T at three different age points in the Tg2576 mouse model of Alzheimer's disease. The Tg2576 mouse exhibits increased amyloid beta deposition that eventually progresses into amyloid beta plaque formation, increased hyper‐phosphorylated tau but does not exhibit neurodegeneration.ResultsOur results show an increase in the MTC signal that predates plaque formation and reported learning and memory deficits in the Tg2576 mouse. This increase in the MTC signal was reversed in a model of antioxidant therapy.ConclusionMTC magnetic resonance imaging can be used to detect early macromolecular changes in the Tg2576 mouse model of Alzheimer's disease. The source of the MTC contrast is likely complex and warrants further investigation in additional preclinical models that represent early and late stage Alzheimer's disease pathologies. Magn Reson Med 71:333–338, 2014. © 2013 Wiley Periodicals, Inc.