bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of dosimetric parameters for predicting radiation‐induced cataract in paediatric patients
Authors: Leangcharoensap Siriphan , Thephamongkhol Kullathorn , Chanwichu Putthipong , Treechairusame Teeradon , Suntornpong Nan , Rongthong Warissara 
Published: August 2024

AbstractIntroductionThis study compared the predictive ability of radiation‐induced cataract between maximum point dose of the lens (Lens Dmax) ≥7 Gy, mean lens dose (Lens Dmean) ≥7 Gy, Lens Dmax ≥10 Gy, and Lens Dmean ≥10 Gy.MethodsPatients aged 3–18 years received cranial irradiation or radiation therapy at head and neck area between January 2010 and December 2019 at our institute were included. Patients without baseline and/or follow‐up eye examination were excluded. Receiver operating characteristic (ROC) curves identified potential predictors and Cox regression analysed correlations between potential factors and cataract occurrence.ResultsSixty‐three patients (122 eyes) were analysed. Cataracts were detected in 14 eyes (11.5%). Median follow‐up time was 4 years (range 0.5–10 years), with cataract developing in a median of 2.5 years (range 0.3–7 years). Three patients (21.4%) developed grade ≥3 cataract. Lens Dmean ≥10 Gy was associated with cataract formation.ConclusionLens Dmean ≥10 Gy showed the highest ability for predicting radiation‐induced cataract in paediatric patients. Net reclassification improvement (NRI) suggested that changing lens dose constraint from Dmax <7 Gy to Dmean <10 Gy would miss 7% of cataract cases but avoid 28% of unnecessary restrictions. Adopting a mean lens dose <10 Gy was suggested as a constraint for lens dose.
Effects of BRCA variation on prognosis in patients with nonmetastatic breast cancer
Authors: Türkel Alper , Onur Ilknur Deliktaş , Anik Hicran , Öner Irem , Erdem Haktan Bağiş , Bahsi Taha , Özalp Özge , Öksüzoğlu Berna , Ateş Öztürk , Karaçin Cengiz 
Published: August 2024

AbstractBackgroundTo compare the clinicopathological characteristics of nonmetastatic breast cancer patients with and without BRCA variations and to investigate the impact of BRCA variations on prognosis.MethodsThis retrospective single‐center study involved an analysis of 938 patients with localized or locally advanced breast cancer who underwent BRCA variation testing. The patients were divided into three groups: 757 were without BRCA variation, 64 were with BRCA1 variation, and 117 were with BRCA2 variation.ResultsIn patients with BRCA1 variation, the Ki67, grade, and frequency of triple‐negative breast cancer were significantly higher than in patients without BRCA variation and with BRCA2 variation. The 5‐year disease‐free survival in patients with BRCA1 variation was significantly worse than the other two groups (without BRCA, BRCA1, and BRCA2; 87.7%, 69.9%, and 95.3%, respectively, p = 0.049). Multivariate analysis detected no significant difference between groups. The pathological complete response rates with neoadjuvant therapy were significantly better in patients with BRCA variations than those without BRCA variations (49.2% vs. 29.6%, p = 0.024).ConclusionPatients with BRCA1 variation had more aggressive tumor characteristics, such as higher Ki67 and higher grade. Also, triple‐negative breast cancer was more common. The presence of BRCA1 variation may worsen survival outcomes. Neoadjuvant treatment responses of patients with BRCA variations were significantly better, and neoadjuvant treatment may contribute to survival outcomes in nonmetastatic patients with BRCA variations.
Simulation‐based education in the Pacific Islands: educational experience, access, and perspectives of healthcare workers
Authors: Robinson Samuel James Alexander , McLeod Elizabeth , Nestel Debra , Pacilli Maurizio , Nataraja Ramesh Mark 
Published: August 2024

AbstractBackgroundThe World Health Organization (WHO) recommends simulation‐based education (SBE) to acquire skills and accelerate learning. Literature focusing on SBE in the Pacific Islands is limited. The aim of this study was to determine Pacific Island healthcare workers' experiences, perspectives, and access to SBE.MethodsThis was a cross‐sectional survey of Pacific Island healthcare workers. We designed an online questionnaire based on existing literature and expert consultation. The questionnaire included Likert scales, multiple‐choice, multi‐select and open‐ended questions. Participants were healthcare workers recruited from professional networks across the region. Descriptive statistics and relative frequencies summarized data, and comparative testing included unpaired t‐tests, Mann–Whitney U, Chi‐squared and Fisher's exact tests. Free‐text responses were presented to illustrate findings.ResultsResponses from 56 clinicians working in 11 Pacific Island countries were included. Fifty were medical doctors (89%), including 31 (55%) surgeons. Participants reported experience with scenario‐based simulation (73%), mannequins (71%), and simulated patients (61%). Discrepancies were identified between previous simulation experience and current access for simulated patients (P = 0.002) and animal‐based part‐task trainers (P = 0.002). SBE was seen as beneficial for procedural skills, communication, decision‐making and teamwork. Interest in further SBE was reported by most participants (96%). Barriers included equipment access (59%), clinical workload (45%) and COVID‐19 restrictions (45%).ConclusionSome Pacific Island healthcare workers have experience with SBE, but their ongoing access is predominantly limited to low‐technology modalities. Despite challenges, there is interest in SBE initiatives. These findings may inform planning for SBE in the Pacific Islands and may be considered prior to programme implementation.
Lithium‐ion battery related burns and emerging trends: a retrospective case series and data analysis of emergency presentations
Authors: Duff Michelle , Manzanero Silvia , Barker Ruth , Barlas Panos , Westacott Genevieve , Lisec Carl 
Published: August 2024

AbstractIntroductionThe rising prevalence of battery powered devices is driving a steady increase in lithium‐ion battery‐related burns. We present a case series of patients with lithium‐ion battery‐related burns and describe the clinical characteristics of this cohort. To further understand emerging trends, we compare our specialty inpatient case series with emergency department (ED) data collated by the Queensland Injury Surveillance Unit (QISU).MethodsThis is a retrospective case series of all patients admitted to the Professor Stuart Pegg Adult Burns Centre for burns relating to lithium‐ion batteries between January 2014 and October 2023. In addition, we provide a retrospective data analysis of ED presentations for lithium‐ion battery‐related burns or blast injuries collated by the QISU.ResultsWithin the case series data, the most common injuries caused by lithium‐ion batteries leading to burn unit admissions were due to e‐scooters (57.1%). Burns relating to e‐scooter batteries were more likely to involve a larger total body surface area and to be deeper in nature, than burns due to other products. The most common ED presentations were from energy storage devices such as powerpacks (43%).ConclusionLithium‐ion battery‐related burns are becoming more frequent. The majority of inpatient managed cases involved burns due to larger lithium‐ion batteries used in e‐scooters. This is the first Australian case series describing severe burns caused by this mechanism. Primary prevention through design, technological and behavioural strategies is required.
Creativity and Deadness. Going Beyond the Binary Division between True and False Self
Authors: Sala‐Hołubowicz Elżbieta 
Published: August 2024

AbstractIn this article, I describe my work with a patient who presented as a creative individual, yet felt like a fictional character. He was driven by a compulsion to maintain and repair broken connections at any cost, utilising his creativity for this purpose. My work with this patient, among others, allowed me to identify a group of patients who feel forced to constantly integrate and transform their external environment. I call them bricoleurs and explain the difference between bricolage and Donald Winnicott's play and Hanna Segal's reparation. I propose that the emergence of this psychological structure is caused by the child's early experiences with significant objects—the childhood necessity to constantly repair and enliven the disturbed mind of the caregiver. One of the metaphors of the article is that of the machine, through which I aim to illustrate the automated internal world of the bricoleur, generated not only by the compulsion to destroy but also by the compulsion to repair and create. In the article, I highlight that working with such patients requires the analyst to carefully examine countertransference and to fully mourn the illusion created in the analytic process. I also reflect on the categories of true and false self, pondering the possibility of moving beyond the binary nature of this division.
Quantitative impacts of hydroelectric dams on the trans‐Amazonian migrations of goliath catfish
Authors: Hauser Marília , Doria Carolina R. C. , Pécheyran Christophe , Ponzevera Emmanuel , Panfili Jacques , Torrente‐Vilara Gislene , Renno Jean‐François , Freitas Carlos Edward , García‐Dávila Carmen , Duponchelle Fabrice 
Published: August 2024

AbstractHydropower expansion is increasingly responsible for connectivity and biodiversity loss in freshwater ecosystems. The Amazon basin, which supports the highest level of freshwater biodiversity globally, faces such unplanned expansion. Here, we demonstrate and quantify the impacts of two major hydroelectric dams on the Madeira River on the trans‐Amazonian movements of one apex predatory catfish (Brachyplatystoma rousseauxii) performing the longest migration known in freshwaters. Using otolith microchemistry, we show that above the dams, the former basin‐wide homing migration between the breeding grounds in the upper Madeira and the nursery in the Amazon estuary has now been replaced by residency. We found evidence suggesting downstream migration of juvenile fish past dams into the Amazon estuary and that some of them home back to the Madeira. However, we did not find evidence that the fish homing back from the estuary can access their breeding grounds in the upper Madeira; they remain blocked below the dams. Our results provide undisputable evidence that the conservation of the species primarily requires the reestablishment of connectivity with the construction of efficient fishways.
YES to women's ordination and NO to violence against women: Gender justice and the LWF communion of churches
Authors: Gudmundsdottir Arnfridur 
Published: August 2024

AbstractGender justice has been a priority of the Lutheran Word Federation (LWF) for decades, much longer than the existence of its Gender Justice Policy (2013) where it is affirmed that gender justice is “a matter of faith.” The LWF has always put great emphasis on the theological problems gender justice issues present, as opposed to an assessment that women's experiences of exclusion and abuses of power are strictly acknowledged and treated as human rights violations. Therefore the committment to gender justice has been strongly tied to the importance of theological education as a critical tool against misleading theologies that justify patriarchal world views, including traditional gender roles and women's submissiveness. The focus in this article is on two major gender justice issues the LWF has called particular attention to, namely women's equal participation to men in leadership roles, including ordained ministry, and violence against women within the church and society at large. Ever since the Seventh Assembly of the LWF in Budapest in 1984, LWF member churches have been urged in assembly messages and resolutions to promote full inclusion of women in the life of church and society and to secure their health and well‐being. Multiple documents, action plans, policies, and reports have been written in order to follow up on the directions from the assemblies regarding women. My aim here is to explore those documents and to lift up what has already been said about women's leadership roles in church and society and about discrimination and violence against women. These documents laid the groundwork for what was stated in the documents passed at the Thirteenth Assembly of the LWF in Poland in September 2023.
Treatment of malignant melanoma with coxsackievirus A21 (V937): An emerging oncolytic virotherapy
Authors: Sakunchotpanit Goranit , Patil Mihir K. , Venkatesh Kaushik , Rohan Thomas Z. , Cheng Debby , Nambudiri Vinod E. 
Published: August 2024

AbstractDespite rising melanoma incidence in recent decades, there is a trend towards overall decreased mortality, reflecting multiple factors including improved treatment options for metastatic disease. While local treatments are the mainstay for early‐stage melanoma, metastatic disease necessitates systemic treatment, with oncolytic virotherapy emerging as a promising option. For this review, articles were retrieved from PubMed from 1964 through 2024. We conducted title, abstract and full‐text screening in accordance with Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines to identify articles describing the use of coxsackievirus A21 (V937), either as monotherapy or as part of combination therapy for malignant melanoma. Fifteen articles met inclusion criteria, offering preclinical and clinical data on V937's efficacy in reducing tumour burden. In addition to reporting manageable safety profiles, clinical trial data examining intratumoral V937 combination therapy with pembrolizumab and ipilimumab also endorsed favourable objective response rates compared to immune checkpoint inhibitor monotherapy (47% vs. 38% and 21% vs. 10%, respectively). In contrast, intravenous V937 monotherapy failed to yield additional benefit in a cohort of patients with Stage IIIC/IV melanoma (n = 3) despite achieving detectable levels in tumour tissue (1 × 109 TCID50). Although small subsets of patients experienced severe adverse effects and study design limitations imposed constraints on collected data, evidence for the efficacy of V937 remains encouraging. With few clinical trials evaluating V937 in melanoma, additional data is required before routine usage in standard treatment for metastatic lesions.
Exploration of potential biomarkers for prurigo nodularis based on plasma‐metabolome analysis
Authors: Wang Duoqin , Peng Lisi , Zhu Yiqi , Xu Shuwen , Xiao Zijing , Shen Yanyun , Jin Taiyu , Shao Yixin , Tang Hui 
Published: August 2024

AbstractPrurigo nodularis (PN) is a chronic and debilitating skin disease with severe itching that negatively impacts patients' quality of life and mental state. However, the treatment options for PN remain limited. Global metabolomics analysis can offer effective information on energy metabolism, pathogenesis and potential diagnostic biomarkers. No study on metabolomic analysis of PN has been reported. To further understand the mechanisms of PN and analyse the plasma metabolite profiles in patients with PN. Targeted‐metabolome analysis of 306 metabolites in plasma from 18 patients with PN and 19 healthy controls was performed using Liquid Chromatography‐tandem Mass Spectrometer analysis. We identified 31 differential metabolites. Most acylcarnitines, long‐chain fatty acids, alpha‐aminobutyric acid, hydroxybutyric acid and lactic acid among these metabolites were up‐regulated in patients with PN; in contrast, glucaric acid, suberic acid, bile acid derivatives and most amino acids were down‐regulated. Positive correlations exist between glucaric acid and itching severity and acylcarnitines and insomnia. Suberic acid and the Investigator's Global Assessment (IGA) scores correlate negatively. Metabolite variation reflects the dysregulation of energy metabolism and chronic systematic inflammation in PN. Several metabolites, such as glucaric acid, suberic acid and acylcarnitines, merit further study as potential biomarkers of disease severity in PN.
Elevated nuclear expression of ZHX1 correlates with poor prognosis in hepatocellular carcinoma (HCC): Comparison of nuclear and cytoplasmic distribution of the ZHX family in HCC cells
Authors: Ma Yu‐Hong , Maekawa Shinya , Takano Shinichi , Yamaguchi Tatsuya , Ishida Takeshi , Takaoka Shinya , Muraoka Masaru , Komiyama Yasuyuki , Takada Hitomi , Suzuki Yuichiro , Sato Mitsuaki , Fan Jianglin , Enomoto Nobuyuki 
Published: August 2024

AbstractAimThe role of the zinc fingers and homeoboxes family (ZHX1–3), transcriptional repressors, through their subcellular localization in hepatocellular carcinoma (HCC), is not fully understood. The present study aimed to examine the differential nuclear and cytoplasmic expression of ZHXs in HCC tissues.MethodsImmunohistochemistry was utilized to detect the expression of ZHXs in 54 liver tissues from HCC (n = 33), hepatitis C (n = 16), and the normal liver tissue surrounding hepatic metastasis of colorectal cancer (n = 5). Next‐generation sequencing and digital polymerase chain reaction identified gene mutations associated with HCC. Kaplan–Meier curves were constructed to evaluate the relationship between ZHX expression and survival. The results were validated using data from The Cancer Genome Atlas. Univariate and multivariate Cox regression analyses were undertaken to identify independent prognostic factors.ResultsHigh nuclear expression of ZHX1 was associated with poor overall survival (OS), while high nuclear expression of ZHX2 correlated with higher recurrence. Conversely, patients with high cytoplasmic expression of ZHX3 had lower recurrence and better OS. Hepatitis B virus‐associated HCC was related to high cytoplasmic expression of ZHX1, which was marginally related to telomerase reverse transcriptase (TERT) promoter mutation‐negative HCC. In contrast, low nuclear expression of ZHX3 was associated with TERT promoter mutation‐positive HCC and HCC patients over 70 years old.ConclusionsThese results suggest that the expression and localization of different ZHXs may be related to HCC progression, potentially inferring genetic backgrounds such as TERT promoter mutation. Further studies on the relationship between HCC and ZHXs will enhance our understanding and control of HCC.
The role of yeast propagation aeration for subsequent primary fermentation with respect to performance and aroma development
Authors: Beugholt Alexander , Geier Dominik Ulrich , Becker Thomas 
Published: August 2024

SummaryDuring the primary fermentation of beer, the yeast simultaneously carries out a series of processes such as cell growth, pH shift, and the formation and degradation of essential flavour components. Harvested yeast from a previous fermentation can be used to inoculate the fermentation or fresh cells can be produced through aerobic propagation. This study investigated the influence of different aeration conditions during Saccharomyces pastorianus ssp. carlsbergensis propagation on the cell count development and the production of secondary metabolites during the subsequent primary beer fermentation. Propagations were conducted by applying six different dissolved oxygen concentrations, and the cells were used as inoculum for the subsequent fermentation. Cell count, pH shift, and the development of key aroma compounds were monitored throughout the primary fermentation to evaluate any difference between the conducted fermentations. The outcomes revealed significant distinctions between fermentations using yeast propagated under elevated oxygen levels and those propagated under reduced oxygen levels. Cells propagated using lower oxygen concentrations showed earlier cell growth with 40% lower final cell counts, resulting in 50% reduced biomass yields. Additionally, lower oxygen concentrations during propagation led to lower pH shifts during primary fermentation with 20% more higher alcohols and elevated formation of acetaldehyde, and esters.
Antifungal efficacy of neroli and palmarosa essential oils against major white button mushroom postharvest pathogens
Authors: Jangam Seshagiri Divyashree , Sellamuthu Periyar Selvam , Emmanuel Rotimi Sadiku 
Published: August 2024

SummaryWhite button mushroom (Agaricus bisporus) has a wide nutritional benefit and a major drawback in supply chain management, due to its short shelf‐life of between 3 and 4 days. Postharvest spoilage caused by Trichoderma and Rhizopus including green‐mould and soft‐rot diseases causes an enormous impact on the shelf‐life of mushroom. Research work is designed to isolate the post‐harvest pathogens from mushroom and determine the effects of eight essential oils on the control of the major postharvest pathogens (T. lentinulae and R. arrhizus). Neroli and palmarosa exhibited 100% inhibition of the two pathogens at 3 and 4 μL/plate, respectively. In‐vivo studies showed that fumigation of neroli and palmarosa essential oils at concentrations of 46.2 and 61.6 μL L−1 exhibited a significant effect on the postharvest pathogens. Major components present in neroli and palmarosa are linalool and geraniol respectively. Findings concluded that neroli and palmarosa could be an efficient natural fungicide to reduce postharvest diseases in white button mushroom.
Preparation and in vitro digestion of algal oil emulsion gel candy with high oxidation stability based on cold‐set gelation method
Authors: Wang Xinshuo , Sun Rongxin , Xia Shuqin , Yu Jingyang 
Published: August 2024

SummaryAlgal oil emulsion gel candies were prepared by a cold‐set gelation method, and the oxidative stability was analysed. Then, the release of algal oil and the microstructural changes of gel candies were investigated under in vitro simulated digestion conditions. The formula of gel candy was found to be 65% sucrose, 5% algal oil emulsion, 1.8% sodium alginate, 1.2% high methoxy pectin and 2% D‐glucono‐δ‐lactone. Cold‐set gel candies loaded with algal oil emulsion had good oxidative stability. Emulsion gel candies could maintain a relatively intact gel network structure in a gastric fluid environment, in which the DHA release rate was less than 5%, whereas the gel structure was loosened at 30 min of digestion in simulated intestinal fluid and destroyed at 60 min, with a release rate of about 75%. Altogether, these results lay a theoretical foundation for facilitating the development of novel DHA functional foods.
Primary endoscopic drainage of an infected renal cyst via a preexisting duodenal fistula
Authors: Mutaz Massad , Lorenzo Dioscoridi , Edoardo Forti , Francesco Pugliese , Marcello Cintolo , Giulia Bonato , Marianna Bravo , Massimiliano Mutignani , Serhan Hashem Abu 
Published: August 2024

AbstractRenal cyst – duodenal fistula is not common and we know little about their presentation and management. The present case report describes a unique endoscopic technique to manage an infected renal cyst through a preexisting duodenal fistula. A retrospective evaluation and analysis were performed of a patient with an infected renal cyst‐duodenal fistula seen in our unit. Patient symptoms, imaging findings, and details of endoscopic procedures were evaluated. The Need for minimally invasive techniques is increasing nowadays as both diagnostic and therapeutic approaches. One of these modalities is the endoscopic management of gastrointestinal fistulae. Minimally invasive techniques can be used as a bridge to major surgeries in those who are not candidates initially.