bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Monofluoromethylation of Tetrahydroisoquinolines by Visible‐Light Induced Direct C(sp3)—H Bond Activation.
Authors: Li Weipeng , Zhu Yunhuang , Duan Yingqian , Zhang Muliang , Zhu Chengjian 
Published: July 2015

AbstractC‐1‐monofluoromethylated tetrahydroisoquinolines are obtained by visible‐light photoredox‐catalyzed reaction of tetrahydroisoquinolines with β‐fluorinated gem‐diols as CF‐source under mild reaction conditions.
ChemInform Abstract: A Convenient Synthesis of Indoloquinolinones via 3‐Arylation of Indole‐2‐carboxamides and PIDA‐Mediated C—N Bond Formation.
Authors: Li Yulin , Zhang‐Negrerie Daisy , Du Yunfei , Zhao Kang 
Published: July 2015

AbstractBiologically important indoloquinolinone derivatives are prepared via a two step procedure.
ChemInform Abstract: Copper‐Catalyzed Aerobic Cascade Reaction for the Conversion of 3,4‐Dihydropyrimidine‐2(1H)‐thiones to Arylthiopyrimidines.
Authors: Lee Ok Suk , Lee HyunKyung , Kim Hyejee , Shin Hyunik , Sohn Jeong‐Hun 
Published: July 2015

Abstract35 examples
ChemInform Abstract: Chemo‐Controlled Cross‐Coupling of Di(hetero)aryl Disulfides with Grignard Reagents: C—C vs.C—S Bond Formation.
Authors: Du Bao‐Xin , Quan Zheng‐Jun , Da Yu‐Xia , Zhang Zhang , Wang Xi‐Cun 
Published: July 2015

AbstractThe protocol for the chemoselective coupling reaction affords either a C—S bond in presence of ferrocene catalyst or the formation of a C—C bond in presence of palladium acetate catalyst.
ChemInform Abstract: Efficient Synthesis of (Arylethynyl)pyrrolo[2,3‐d]pyrimidines by Stille Coupling.
Authors: Bucevicius Jonas , Tumkevicius Sigitas 
Published: July 2015

AbstractA wide range of new pyrrolo[2,3‐d]pyrimidine derivatives, including those with different arylethynyl groups in position C‐2 and C‐4 of the heterocycle, are obtained by palladium‐catalyzed cross‐coupling reaction of 2,4‐dichloro‐7‐methylpyrrolo[2,3‐d]pyrimidine (I) with (arylethynyl)tributylstannanes.
ChemInform Abstract: Ligand‐Free Pd‐Catalyzed and Copper‐Assisted C—H Arylation of Quinazolin‐4‐ones with Aryl Iodides under Microwave Heating.
Authors: Laclef Sylvain , Harari Marine , Godeau Julien , Schmitz‐Afonso Isabelle , Bischoff Laurent , Hoarau Christophe , Levacher Vincent , Fruit Corinne , Besson Thierry 
Published: July 2015

AbstractSeveral quinazolin‐4‐ones and pyrido‐pyrimidin‐4‐one derivatives thereof are transformed according to the title reaction.
ChemInform Abstract: Expeditious Synthesis of (.+‐.)‐Diethyl 2‐Alkyl‐ and 2‐Aryl‐(3‐oxoisoindolin‐1‐yl)phosphonates Catalyzed by OSU‐6.
Authors: Muddala Nagendra Prasad , Nammalwar Baskar , Bunce Richard A. 
Published: July 2015

AbstractStarting from 2‐carboxybenzaldehyde, triethyl phosphite and aryl, benzyl, or alkyl amines an efficient preparation of the title products is performed.
ChemInform Abstract: Versatile Synthesis of Phospholides from Open‐Chain Precursors. Application to Anellated Pyrrole— and Silole—Phosphole Rings.
Authors: Xu Youzhi , Wang Zhihua , Gan Zhenjie , Xi Qiuzhen , Duan Zheng , Mathey Francois 
Published: July 2015

AbstractThe first general synthesis of phospholides and annelated phospholides starting from open‐chain precursors is presented.
ChemInform Abstract: Synthesis of Chalcogenophenes via Cyclization of 1,3‐Diynes Promoted by Iron(III) Chloride and Dialkyl Dichalcogenides.
Authors: Bilheri Filipe N. , Stein Andre L. , Zeni Gilson 
Published: July 2015

AbstractThe dibutyl diselenide‐mediated reaction furnishes symmetrical and unsymmetrical selenophenes under mild conditions.
ChemInform Abstract: Stereodivergent Hydrogermylations of α‐Trifluoromethylated Alkynes and Their Applications in Cross‐Coupling Reactions.
Authors: Schweizer Stephane , Tresse Cedric , Bisseret Philippe , Lalevee Jacques , Evano Gwilherm , Blanchard Nicolas 
Published: July 2015

Abstract(Z)‐ and (E)‐α‐CF3‐vinylgermanes are regio‐ and stereoselectively prepared under radical or Pd‐catalyzed conditions.
ChemInform Abstract: Prenylated Indole Alkaloids from the Marine‐Derived Fungus Paecilomyces variotii.
Authors: Zhang Peng , Li Xiao‐Ming , Wang Jia‐Ning , Li Xin , Wang Bin‐Gui 
Published: July 2015

AbstractEvaluation of the cytotoxic activity of the newly isolated indole alkaloids, dihydrocarneamide A (I) and iso‐notoamide (II), reveals a weak cytotoxicity.
ChemInform Abstract: Isoprenylated Flavones from Garcinia bracteata and Their anti‐Tobacco Mosaic Virus Activity
Authors: Hu Qiufen , Ning Ping , Li Limei , Lou Jie , Cheng Yang , Shi Lei , Shu Duntao , Gao Xue‐Mei , Yang Yuehong , Wang Yede 
Published: July 2015

Abstractisolation and structure elucidation of two new isoprenylated flavones, bracteflavone A (I) and B (II), along with four known flavones with potential anti‐TMV activity
ChemInform Abstract: Growth of GaN Layers on Sapphire by Low‐Temperature‐Deposited Buffer Layers and Realization of p‐Type GaN by Magesium Doping and Electron Beam Irradiation (Nobel Lecture)
Authors: Amano Hiroshi 
Published: July 2015

AbstractReview: personal account of the background of the studies that led to the technologies for growing GaN and producing p‐GaN; 61 refs.
ChemInform Abstract: Digging into the Mechanism of Oxidative Pd(II)‐Catalyzed Aminations
Authors: Lorion Melanie M. , Nahra Fady , Ly Vu Linh , Mealli Carlo , Messaoudi Abdelatif , Uron Frederic , Oble Julie , Pou Giovanni 
Published: July 2015

AbstractReview: 49 refs.
Self‐Assembly of Organic Building Blocks with Directly Exfoliated Graphene to Fabricate Di‐ and Tricomponent Hybrids
Authors: Xing Pengyao , Bai Linyi , Chen Hongzhong , Tham Phoebe Huijun , Hao Aiyou , Zhao Yanli 
Published: July 2015

AbstractIn this work, we developed a strategy to fabricate self‐assembled aggregates encapsulating graphene from direct exfoliation of graphite. Naphthalene‐anhydride‐appended glutamic acid (NG) and pyrene‐appended glutamic acid (PG) were utilized to exfoliate graphite to generate few‐layer graphene in basic aqueous media. Acidification‐triggered self‐assembly of PG could encapsulate graphene sheets to give graphene@microsheet hybrids. Melamine (Mm) was introduced to induce the morphological transformation of PG from microsheets to twisted fibers with columnar packing. In the presence of graphene, this transformation allowed the fabrication of twisted‐fiber‐encapsulated graphene (graphene@twist fiber). Tricomponent hybrids were also built up via in situ preparation of gold nanoparticles (AuNPs) on the negatively charged surface of few‐layer graphene during the self‐assembly process. This study presents an approach to construct directly exfoliated graphene‐based hybrids through self‐assembly.
Identification of intranuclear inclusions is useful for the cytological diagnosis of ovarian clear cell carcinoma
Authors: Naka Masaki , Ohishi Yoshihiro , Kaku Tsunehisa , Watanabe Sumiko , Tamiya Sadafumi , Ookubo Fumihiko , Kato Kiyoko , Oda Yoshinao , Sugishima Setsuo 
Published: July 2015

ObjectiveThe aim of this study was to clarify the diagnostic significance of the presence of intranuclear inclusions in clear cell carcinoma (CCC).Materials and MethodsWe analyzed 98 imprint specimens and 53 ascites specimens from 98 ovarian carcinoma cases [28 CCCs, 37 serous carcinomas (SCs), 22 endometrioid carcinomas (ECs), and 11 mucinous carcinomas (MCs)]. We examined (1) frequency of intranuclear inclusion‐positive cases of each ovarian carcinoma subtype, using imprint specimens, (2) frequency of intranuclear inclusion‐positive cells of each ovarian carcinoma subtype, using imprint specimens, (3) frequency of intranuclear inclusion‐positive cases of each ovarian carcinoma subtype, using ascites specimens, and (4) sensitivity and specificity of the presence of intranuclear inclusions for the cytological diagnosis of CCC.Results(1) The frequency of intranuclear inclusion‐positive cases in CCC (96.4%) was significantly higher than in SC (13.5%), EC (13.6%), and MC (18.2%) (P < 0.001). Two or more intranuclear inclusions in a single nucleus were observed only in CCC. (2) The frequency of intranuclear inclusion‐positive cells in CCC (median, 0.41%) was significantly higher than in non‐CCC subtypes (0.010%) (P < 0.001). (3) Using ascites specimens, the frequency of intranuclear inclusion‐positive cases in CCC (78.6%) was significantly higher than in SC (10.3%), EC (0%), and MC (0%) (P < 0.001). (4) The sensitivity of intranuclear inclusions was 96.4%, and the specificity was 85.7%.ConclusionsThe identification of intranuclear inclusions, in particular a high frequency and multiple intranuclear inclusions in a single nucleus, is useful for the cytological diagnosis of CCC. Furthermore, these results may be applicable to ascites cytology. Diagn. Cytopathol. 2015;43:879–884. © 2015 Wiley Periodicals, Inc.
Characterization and Validation of a Canine Pruritic Model
Authors: Aberg Gunnar A.K. , Arulnesan Nada , Bolger Gordon T. , Ciofalo Vincent B. , Pucaj Kresimir 
Published: July 2015

ABSTRACT

Preclinical Research

The mechanisms mediating canine pruritus are poorly understood with few models due to limited methods for inducing pruritus in dogs. Chloroquine (CQ) is a widely used antimalarial drug that causes pruritus in humans and mice. We have developed a canine model of pruritus where CQ reliably induced pruritus in all dogs tested following intravenous administration. This model is presently being used to test antipruritic activity of drug candidate molecules. This publication has been validated in a blinded cross‐over study in eight beagle dogs using the reference standards, oclacitinib and prednisolone, and has been used to test a new compound, norketotifen. All compounds reduced CQ‐induced pruritus in the dog. The sensitivity of the model was demonstrated using norketotifen, which at three dose levels, dose‐dependently, inhibited scratching events compared with placebo. Drug Dev Res 76 : 246‐250, 2015. © 2015 Wiley Periodicals, Inc.
Mid wall fibrosis on CMR with late gadolinium enhancement may predict prognosis for LVAD and transplantation risk in patients with newly diagnosed dilated cardiomyopathy—preliminary observations from a high‐volume transplant centre
Authors: Venero Jose V. , Doyle Mark , Shah Moneal , Rathi Vikas K. , Yamrozik June A. , Williams Ronald B. , Vido Diane A. , Rayarao Geetha , Benza Raymond , Murali Srinivas , Glass Jerry , Olson Peter , Sokos George , Biederman Robert W.W. 
Published: July 2015

AbstractBackgroundPatients with newly diagnosed dilated cardiomyopathy (DCM) and advanced heart failure have a very high morbidity and mortality with an unpredictable clinical course. We investigated the role of cardiovascular magnetic resonance (CMR) imaging using late gadolinium enhancement (LGE) in this cohort of high‐risk patients. We hypothesized that LGE has high prognostic value in primary DCM patients referred for possible transplantation/left ventricular assist device (LVAD) consideration.MethodsOver 49 consecutive months, 61 consecutives DCM patients were referred for standard CMR(1.5T, GE) to interrogate the LV pattern, distribution, and extent of LGE (MultiHance, Princeton, NJ). Inclusion criteria for a primary non‐ischaemic DCM and EF <45% were met in 31 patients. DCM patients were categorized into: (i) presence of midwall LV stripe (+Stripe) and (ii) absence of midwall stripe (−Stripe) groups. Primary outcome was defined by the composite of death, need for LV assist device (LVAD), and urgent orthotopic cardiac transplantation (Tx) during a 12‐month follow‐up period. Kaplan–Meier survival analysis was conducted grouping patients by +Stripe and −Stripe.ResultsThere were no differences between groups for demographics, blood pressure, labs, baseline LVEF, NYHA class, or invasive haemodynamics. There were 18 patients (58%) with +Stripe. Nine events occurred: seven patients required urgent Tx and/or LVAD implantation and two patients died. The +Stripe categorization strongly predicted the need for LVAD, urgent Tx surgery, and death (log‐rank = 9, P = 0.002). All the events occurred in the +Stripe patients with no MACE experienced in the −Stripe group. The −Stripe group experienced marked signs of improvement in LVEF (P = 0.01) at follow‐up. LVEDD was predictive of need for LVAD/Tx and death by univariate analysis. Otherwise, no common clinical metric such as LVEF, LVEDV, RVEF, RVEDV, or any invasive haemodynamic parameter predicted MACE.ConclusionsThe presence of +Stripe on CMR is strongly predictive of LVAD, transplant need, and death during a 12‐month follow‐up period in DCM patients in this proof of concept study. All −Stripe patients survived without experiencing any events. Incorporating CMR imaging into routine clinical practice may have prognostic value in DCM patients; indicating conservative management in low‐risk patients while expectantly managing high‐risk patients.
Thiamethoxam: Assessing flight activity of honeybees foraging on treated oilseed rape using radio frequency identification technology
Authors: Thompson Helen , Coulson Mike , Ruddle Natalie , Wilkins Selwyn , Harkin Sarah 
Published: July 2015

Abstract

The present study was designed to assess homing behavior of bees foraging on winter oilseed rape grown from seed treated with thiamethoxam (as Cruiser OSR), with 1 field drilled with thiamethoxam-treated seed and 2 control fields drilled with fungicide-only–treated seed. Twelve honeybee colonies were used per treatment group, 4 each located at the field edge (on-field site), at approximately 500 m and 1000 m from the field. A total of nearly 300 newly emerged bees per colony were fitted (tagged) with Mic3 radio frequency identification (RFID) transponders and introduced into each of the 36 study hives. The RFID readers fitted to the entrances of the test colonies were used to monitor the activity of the tagged bees for the duration of the 5-wk flowering period of the crop. These activity data were analyzed to assess any impact on flight activity of bees foraging on the treated compared with untreated crops. Honeybees were seen to be actively foraging within all 3 treatment groups during the exposure period. The data for the more than 3000 RFID-tagged bees and more than 90 000 foraging flights monitored throughout the exposure phase for the study follow the same trends across the treatment and controls and at each of the 3 apiary distances, indicating that there were no effects from foraging on the treated crop. Under the experimental conditions, there was no effect of foraging on thiamethoxam-treated oilseed rape on honeybee flight activity or on their ability to return to the hive. Environ Toxicol Chem 2016;35:385–393. © 2015 SETAC
Shelf life of ground beef enriched with omega‐3 and/or conjugated linoleic acid and use of grape seed extract to inhibit lipid oxidation
Authors: Gómez Inmaculada , Beriain María J. , Mendizabal Jose A. , Realini Carolina , Purroy Antonio 
Published: July 2015

AbstractThe shelf life and oxidative stability of refrigerated raw ground beef enriched with omega‐3 and/or conjugated linoleic acid (CLA) were studied. Grape seed extract (GSE) was used to inhibit lipid oxidation in the ground beef. Eight treatments of ground beef were established according to the enrichment of beef (control, enriched with omega‐3, with CLA, or with omega‐3 plus CLA) and the use of GSE (0 and 250 mg GSE/kg product). Fresh beef was ground and mixed with GSE and salt. Treatments of beef were stored at 2 ± 1°C in aerobic packaging for 0, 1, 3, and 6 days under retail display conditions. Oxidation stability (thiobarbituric acid‐reactive substances [TBARS]), pH, instrumental color, metmyoglobin formation, and sensory attributes (color and odor) were measured. Omega‐3‐enriched beef increased the oxidation level at day 6 as determined by TBARS (P < 0.05), but the instrumental color was not affected. The enrichment of CLA improved the coordinates of color (P < 0.05) until day 3 and decreased the oxidation at day 6 (P < 0.05). There were no differences in color and odor values among the types of beef during display, except at day 3, when CLA treatments had the highest scores. Addition of GSE decreased the oxidation level (P < 0.001) and did not affect the instrumental color or the sensory parameters.
Interpersonal traits of psychopathy linked to reduced integrity of the uncinate fasciculus
Authors: Wolf Richard C. , Pujara Maia S. , Motzkin Julian C. , Newman Joseph P. , Kiehl Kent A. , Decety Jean , Kosson David S. , Koenigs Michael 
Published: July 2015

AbstractPsychopathy is a personality disorder characterized by callous lack of empathy, impulsive antisocial behavior, and criminal recidivism. Here, we performed the largest diffusion tensor imaging (DTI) study of incarcerated criminal offenders to date (N = 147) to determine whether psychopathy severity is linked to the microstructural integrity of major white matter tracts in the brain. Consistent with the results of previous studies in smaller samples, we found that psychopathy was associated with reduced fractional anisotropy in the right uncinate fasciculus (UF; the major white matter tract connecting ventral frontal and anterior temporal cortices). We found no such association in the left UF or in adjacent frontal or temporal white matter tracts. Moreover, the right UF finding was specifically related to the interpersonal features of psychopathy (glib superficial charm, grandiose sense of self‐worth, pathological lying, manipulativeness), rather than the affective, antisocial, or lifestyle features. These results indicate a neural marker for this key dimension of psychopathic symptomatology. Hum Brain Mapp 36:4202–4209, 2015. © 2015 Wiley Periodicals, Inc.
Population pharmacokinetics of meropenem during continuous infusion in surgical ICU patients
Authors: Kees Martin G. , Minichmayr Iris K. , Moritz Stefan , Beck Stefanie , Wicha Sebastian G. , Kees Frieder , Kloft Charlotte , Steinke Thomas 
Published: July 2015

AbstractContinuous infusion of meropenem is a candidate strategy for optimization of its pharmacokinetic/pharmacodynamic profile. However, plasma concentrations are difficult to predict in critically ill patients. Steady‐state concentrations of meropenem were determined prospectively during continuous infusion in 32 surgical ICU patients (aged 21‐85 years, body weight 55‐125 kg, APACHE II 5‐29, measured creatinine clearance 22.7‐297 mL/min). Urine was collected for the quantification of renal clearance of meropenem and creatinine. Cystatin C was measured as an additional marker of renal function. Population pharmacokinetic models were developed using NONMEM®, which described total meropenem clearance and its relationship with several estimates of renal function (measured creatinine clearance CLCR, Cockcroft‐Gault formula CLCG, Hoek formula, 1/plasma creatinine, 1/plasma cystatin C) and other patient characteristics. Any estimate of renal function improved the model performance. The strongest association of clearance was found with CLCR (typical clearance = 11.3 L/h × [1 + 0.00932 × (CLCR – 80 mL/min)]), followed by 1/plasma cystatin C; CLCG was the least predictive covariate. Neither age, weight, nor sex was found to be significant. These models can be used to predict dosing requirements or meropenem concentrations during continuous infusion. The covariate CLCR offers the best predictive performance; if not available, cystatin C may provide a promising alternative to plasma creatinine.
Selection of microalgae for simultaneous biogas upgrading and biogas slurry nutrient reduction under various photoperiods
Authors: Wang Zhongwei , Zhao Yongjun , Ge Zhigang , Zhang Hui , Sun Shiqing 
Published: July 2015

AbstractBACKGROUNDFive microalgal strains characterized by high biogas tolerance and rapid growth were cultured in biogas slurry to identify strains capable of simultaneous nutrient removal and biogas upgrading. The potential contribution of these algae to these processes was evaluated for different photoperiods.RESULTSThe growth rates of the microalgae were inversely related to their initial concentrations. The growth rates of Scenedesmus obliquus (FACHB‐31), Chlorella vulgaris (FACHB‐416), and Nitzschia palea (FACHB‐211) were higher than those of Selenastrum capricornutum (FACHB‐271) and Anabaena spiroides (FACHB‐498) under a moderate photoperiod (14 h light: 10 h dark). Under this condition and an initial CH4 concentration of 61.38% (v/v), the final concentrations in crude biogas were 84.28%, 84.21%, and 83.46% for S. obliquus, C. vulgaris, and N. palea, respectively. Biogas slurry nutrients were optimally reduced under the moderate photoperiod.CONCLUSIONAppropriate selection of microalgal strains for the treatment of biogas slurry and crude biogas is crucial to achieve optimal nutrient removal and biogas upgrading. © 2015 Society of Chemical Industry
Photocatalytic ozonation of pyridine‐based herbicides by N‐doped titania
Authors: Solís Rafael R , Javier Rivas F , Gimeno Olga , Pérez‐Bote José Luis 
Published: July 2015

AbstractBACKGROUNDA mixture of three pyridine herbicides in water (clopyralid, triclopyr and picloram) has been treated with photocatalytic processes, involving oxygen or ozone. Nitrogen doped and undoped titania were used in the process. Toxicity evolution during photocatalytic ozonation was monitored considering BOD, Daphnia parvula and fitotoxicity trials.RESULTSN doped titania with an optimized photoactivity was tested in photocatalytic ozonation, leading to nearly 95% mineralization in 180 min. This catalyst was characterized by SEM, TEM, XRD and XPS techniques (13.5 nm crystal size, anatase phase, 1% N, and formation of O‐Ti‐N linkage). No loss of photocatalytic activity was observed after five consecutive runs. Although no toxicity from the parent compounds was observed, this parameter increased during the early stages of the oxidation process. When parent compounds were totally degraded and dechlorination was completed, toxicity decayed again to negligible values.CONCLUSIONN doping improves bare titania photoactivity through an optimum amount of N. Photocatalysis/ozone showed better behavior than photocatalysis/oxygen in herbicide removal and mineralization, and no significant loss of activity was observed after five runs. Toxicity initially increased due to toxic byproducts formation; however, it decreased after their abatement. © 2015 Society of Chemical Industry
Efficacy of topical cross‐linked hyaluronic acid hydrogel in preventing post laminectomy/laminotomy fibrosis in a rat model
Authors: Wu Cheng‐Yi , Huang Yi‐Hung , Lee Jung‐Shun , Tai Ta‐Wei , Wu Po‐Ting , Jou I‐Ming 
Published: July 2015

ABSTRACTPost‐laminectomy/laminotomy epidural fibrosis (EF) has been implicated as an important cause of failed back syndrome (FBS). The various clinical approaches used to control EF yield mixed outcomes. Cross‐linked hyaluronic acid hydrogel (cHA) was synthesized to increase mechanical stability and residence time. We evaluated the therapeutic attenuation of proliferative EF in laminectomy/laminotomy groups treated and not treated with cHA. A bilateral T11‐L1 total laminectomy or unilateral T12 laminotomy was done on four groups (n = 10 each) of Sprague‐Dawley rats and then histologically examined 2 months post‐surgery: (I) laminectomy group treated with and (II) not treated with cHA, (III) laminotomy group treated with and (IV) not treated with cHA. The grade of EF, the diameters within the spinal canal, dura mater thickness, and the area of the epidural space, subarachnoid space, and conus medullaris space were assessed. The cHA‐treated subgroups (I, III) had a significantly lower grade of EF, thinner dura mater, and larger epidural and subarachnoid spaces than did the control subgroups (II, IV) (p < 0.05). The cHA formed a solid interpositional membrane barrier that prevented invasive fibrosis, and also helped reduce pathological changes to the adjacent structures. In conclusion, topically applied cHA is effective for reducing EF. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:299–306, 2016.