bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nitric Oxide Donor s‐Nitroso‐n‐Acetyl Penicillamine (SNAP) Alters Meiotic Spindle Morphogenesis in Xenopus Oocytes
Authors: Gelaude Armance , Marin Matthieu , Cailliau Katia , Jeseta Michal , Lescuyer‐Rousseau Arlette , Vandame Pauline , Nevoral Jan , Sedmikova Marketa , Martoriati Alain , Bodart Jean‐François 
Published: April 2015

ABSTRACTNitric Oxide (NO) has been involved in both intra‐ and extra‐cellular signaling pathways in a wide range of organisms, and can be detected in some reproductive tissues. Based upon previous results reporting that NO‐donor SNAP (s‐nitroso‐n‐acetyl penicillamine) promoted the release from the metaphase II‐anaphase II block in amphibian eggs, the aim of the present study was to assess the influence of SNAP on the activation of the molecular mechanisms triggering meiotic resumption of Xenopus oocytes, analogous to G2/M transition of the cell cycle. A high concentration of SNAP (2.5 mM) was found to inhibit the appearance of the white spot (meiotic resumption) and promoted alteration of spindle morphogenesis leading to atypical structures lacking bipolarity and correct chromosomes equatorial alignment. The medium acidification (pH = 4) promoted by SNAP specifically impacted the white spot occurrence. However, even when pH was restored to 7.4 in SNAP medium, observed spindles remained atypical (microtubule disorganization), suggesting SNAP impacted spindle assembly regardless of the pH. n‐Acetyl‐d,l‐penicillamine disulfide, a degradation product of SNAP with the same molecular characteristics, albeit without release of NO, yielded spindle assemblies typical of metaphase II suggesting the specificity of NO action on meiotic spindle morphogenesis in Xenopus oocytes. J. Cell. Biochem. 116: 2445–2454, 2015. © 2015 Wiley Periodicals, Inc.
Cytokine Stimulation of MUC4 Expression in Human Female Reproductive Tissue Carcinoma Cell Lines and Endometrial Cancer
Authors: Chapela Patricia J. , Broaddus Russell R. , Hawkins Shannon M. , Lessey Bruce A. , Carson Daniel D. 
Published: April 2015

ABSTRACTMUC4, a transmembrane glycoprotein, interferes with cell adhesion, and promotes EGFR signaling in cancer. Studies in rat models have demonstrated steroid hormonal regulation of endometrial MUC4 expression. In this study, qRT‐PCR screening of mouse tissues determined that Muc4 mRNA also was robustly expressed in mouse uteri. Previous studies from our labs have demonstrated MUC4 mRNA was expressed at levels <1% of MUC1 mRNA in human endometrium and endometriotic tissue. Multiple human endometrial adenocarcinoma cell lines were assayed for MUC4 mRNA expression revealing extremely low basal expression in the Ishikawa, RL‐95‐2, AN3CA, and KLE lines. Moderate to high expression was observed in HEC50 and HEC‐1A cells. MUC4 mRNA expression was not affected by progesterone and/or estrogen treatment, but was greatly stimulated at both mRNA and protein levels by proinflammatory cytokines (IFN‐γ and TNF‐α), particularly when used in combination. In endometrial tissue, MUC4 mRNA levels did not change significantly between normal or cancerous samples; although, a subset of patients with grade 1 and 2 tumors displayed substantially higher expression. Likewise, immunostaining of human endometrial adenocarcinoma tissues revealed little to no staining in many patients (low MUC4), but strong staining in some patients (high MUC4) independent of cancer grade. In cases where staining was observed, it was heterogeneous with some cells displaying robust MUC4 expression and others displaying little or no staining. Collectively, these observations demonstrate that while MUC4 is highly expressed in the mouse uterus, it is not a major mucin in normal human endometrium. Rather, MUC4 is a potential marker of endometrial adenocarcinoma in a subset of patients. J. Cell. Biochem. 116: 2649–2657, 2015. © 2015 Wiley Periodicals, Inc.
MiR‐25 Suppresses 3T3‐L1 Adipogenesis by Directly Targeting KLF4 and C/EBPα
Authors: Liang Wei‐Cheng , Wang Yan , Liang Pu‐Ping , Pan Xu‐Qing , Fu Wei‐Ming , Yeung Venus Sai‐Ying , Lu Ying‐Fei , Wan David Chi‐Cheong , Tsui Stephen Kwok‐Wing , Tsang Suk‐Ying , Ma Wen‐Bin , Zhang Jin‐Fang , Waye Mary Miu‐Yee 
Published: April 2015

ABSTRACTIn the past decade, miRNA emerges as a vital player in orchestrating gene regulation and maintaining cellular homeostasis. It is well documented that miRNA influences a variety of biological events, including embryogenesis, cell fate decision, and cellular differentiation. Adipogenesis is an organized process of cellular differentiation by which pre‐adipocytes differentiate towards mature adipocytes. It has been shown that adipogenesis is tightly modulated by a number of transcription factors such as PPARγ, KLF4, and C/EBPα. However, the molecular mechanisms underlying the missing link between miRNA and adipogenesis‐related transcription factors remain elusive. In this study, we unveiled that miR‐25, a member of miR‐106b‐25 cluster, was remarkably downregulated during 3T3‐L1 adipogenesis. Restored expression of miR‐25 significantly impaired 3T3‐L1 adipogenesis and downregulated the expression of serial adipogenesis‐related genes. Further experiments presented that ectopic expression of miR‐25 did not affect cell proliferation and cell cycle progression. Finally, KLF4 and C/EBPα, two key regulators of adipocyte differentiation, were experimentally identified as bona fide targets for miR‐25. These data indicate that miR‐25 is a novel negative regulator of adipocyte differentiation and it suppressed 3T3‐L1 adipogenesis by targeting KLF4 and C/EBPα, which provides novel insights into the molecular mechanism of miRNA‐mediated cellular differentiation. J. Cell. Biochem. 116: 2658–2666, 2015. © 2015 Wiley Periodicals, Inc.
Conversion to complete resection with mFOLFOX6 with bevacizumab or cetuximab based on K‐ras status for unresectable colorectal liver metastasis (BECK study)
Authors: Hatano Etsuro , Okuno Masayuki , Nakamura Kojiro , Ishii Takamichi , Seo Satoru , Taura Kojiro , Yasuchika Kentaro , Yazawa Takefumi , Zaima Masazumi , Kanazawa Akiyoshi , Terajima Hiroaki , Kaihara Satoshi , Adachi Yukihito , Inoue Naoya , Furumoto Katsuyoshi , Manaka Dai , Tokka Atsuo , Furuyama Hiroaki , Doi Koji , Hirose Tetsuro , Horimatsu Takahiro , Hasegawa Suguru , Matsumoto Shigemi , Sakai Yoshiharu , Uemoto Shinji 
Published: April 2015

AbstractBackgroundPatients with colorectal liver metastasis (CRLM) might be down‐staged by chemotherapy from an initially unresectable stage to a resectable stage. Because the tumor response to preoperative chemotherapy has been correlated with resection rate, the improved efficacy from the concept that only the patients without K‐ras mutations receive an anti‐EGFR antibody might be expected to increase the conversion rate. The purpose of this study is to evaluate the conversion rate from unresectable CRLM to complete resection.MethodsWe conducted a multi‐institutional phase II trial for unresectable CRLM. Patients received mFOLFOX6 with either bevacizumab (bev) or cetuximab (cet) based on K‐ras status (UMIN000004310). Planned treatment was for six cycles during which tumors were assessed for resectability every three cycles. Patients whose disease was unresectable after six cycles switched their chemotherapy regimen from mFOLFOX6 to FOLFIRI. The primary endpoint was R0 resection rate.ResultsThirty‐five patients with unresectable CRLM were enrolled. A total of 22/12 patients with K‐ras wild‐type/mutant (wt/mt) were treated with mFOLFOX6 plus cet/bev, respectively. The overall response rate was 64.7% (wt/mt; 77.3%/41.7%, P = 0.04). In 20 patients (58.8%), hepatectomy was performed according to protocol treatment, and the conversion rate was 72.7%/33.3% in wt/mt patients, respectively (P = 0.03). Finally, 23 patients (67.6%) underwent hepatectomy, and the conversion rate was 77.2%/50.0% in wt/mt patients (P = 0.09). The overall R0 resection rate was 47.1% (wt/mt; 50.0%/41.7%, P = 0.36).ConclusionsThis prospective study showed that combined chemotherapy based on K‐ras status can facilitate conversion to resection in patients with unresectable CRLM.
When is pay for performance related to employee creativity in the Chinese context? The role of guanxi HRM practice, trust in management, and intrinsic motivation
Authors: Zhang Yong , Long Lirong , Wu Tsung‐yu , Huang Xu 
Published: April 2015

SummaryThis study aims to provide new insights into the reward–creativity link in the Chinese context by exploring the moderating effect of guanxi human resource management (HRM) practice—reflecting the extent to which HR decisions are influenced by personal relationships in an organization—on the relationship between pay for performance (PFP) and employee creativity. Using two independent samples that were composed of 222 and 216 supervisor–subordinate dyads from Mainland China and Taiwan, we found that the effect of pay for performance on creativity was invariantly moderated by perceived guanxi HRM practice in such a way that when guanxi HRM practice was low, PFP had stronger positive effects on creativity. Furthermore, trust in management, as reduced by guanxi HRM practice, mediated this moderating effect. Moreover, moderated path analysis revealed that intrinsic motivation mediated these moderated relationships among PFP, guanxi HRM practice, trust in management, and creativity. Findings shed light on the processes through which, and the conditions under which, PFP may promote creativity. Copyright © 2015 John Wiley & Sons, Ltd.
Advanced technologies for UHD curved OLED TV
Authors: Han Chang‐Wook , Park Jung‐Soo , Choi Hong‐Seok , Kim Tae‐Shick , Shin Young‐Hoon , Shin Hong‐Jae , Lim Moo‐Jong , Kim Bong‐Chul , Kim Han‐Seop , Kim Bum‐Sik , Tak Yoon‐Heung , Oh Chang‐Ho , Cha Soo‐Youle , Ahn Byung‐Chul 
Published: April 2015

AbstractUltra‐high definition (UHD) curved organic light‐emitting diode (OLED) TV requires advanced technologies to realize mass production. White, red, green, and blue (WRGB) OLED TV based on stripe WRGB sub‐pixel structure has distinct advantages in luminance of white, faster response time, wider viewing angle, and potential higher resolution. In this paper, we will introduce technological progress for commercializing large‐sized and UHD curved OLED TV. Those technologies including oxide thin film transistors, white OLEDs, compensation circuit, and solid phase encapsulation enable panel size scalability as well as mass production with lifetime reliability.
Calculation of film stress from pitch measurements in LCD panel manufacturing
Authors: Burdette Steven R. 
Published: April 2015

AbstractA method based on inverting a finite element model is presented for determining film stress from pitch changes before and after a film deposition step in liquid‐crystal display panel manufacturing. It differs from the conventional methods by making use of in‐plane deformation rather than out‐of‐plane measurements to calculate film stress. The resulting film stress is confounded with glass structural relaxation. Measurements of out‐of‐plane deformation at the edge of the sheet can be used with the pitch measurements to separate the effects of glass structural relaxation and film stress.
Optical deformations of azobenzene polymers: Orientation approach vs. photofluidization concept
Authors: Saphiannikova Marina , Toshchevikov Vladimir 
Published: April 2015

AbstractRecently in literature appeared quite a number of claims that cyclic isomerization of azobenzene (azo) chromophores may cause an athermal transition of the glassy azo‐polymers or, more generally, glassy azo‐materials into a fluid state. In this study, we provide a critical overview of recently published findings and show that observations presented not only fail to support this photofluidization concept but rather show the contrary. The glassy azo‐materials remain in the solid state under light illumination. Thus, the sound claims made in the titles of recent studies contradict the experimental observations presented in their texts. Further, we discuss a number of rigorous studies, which present strong evidence against the photofluidization concept, including our own theoretical predictions made in the frame of orientation approach. This approach provides values of anisotropic light‐induced stress large enough to deform glassy azo‐polymers with diverse chemical structures. The values of the stress are in a perfect accord with recent experimental findings, which show deformation of the bonds in metal and graphene multilayers adsorbed on the top of illuminated azo‐polymers.
Radical Polymerization of Alkali Acrylates in Aqueous Solution
Authors: Drawe P. , Buback M. , Lacík I. 
Published: April 2015

Monomer conversion versus time profiles for the radical polymerization of ionized acrylic acid (AA), 0.6 to 0.8 mol L−1 in aqueous solution, are measured at 50 °C via inline near‐infrared spectroscopy mostly on fully ionized AA, i.e., of alkali acrylates. Ionization reduces polymerization rate with the size of this effect being dependent on the type and on the concentration of the alkali counter cation, which is varied from lithium to rubidium. Polymerization rate becomes very small upon shielding the cation by complexation, whereas an enhancement of cation concentration, by addition of alkali chloride, may enhance polymerization rate such as to even reach the high rates observed with the radical polymerization of nonionized AA.
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On the equivalent circuit, input impedance, reflection coefficient, and bandwidth of printed monopole antenna
Authors: Bhattacharjee S. , Kshetrimayum R. S. , Bhattacharjee R. 
Published: April 2015

ABSTRACTThis article presents the derivation of a closed form expression for input admittance of horizontal electric dipole over an ungrounded substrate using transmission line analogy. The derived expression is then used to calculate reflection coefficient of rectangular and circular printed monopole antenna (PMA) fed by a microstrip line. Analytical result for the reflection coefficient of both rectangular and circular PMA is verified using high frequency structure simulator (HFSS). For circular PMA, analytical, and simulated results are also compared with the measured results available in literature. Effect of the dimension and dielectric material on the antenna bandwidth is also studied and verified by HFSS. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:1535–1538, 2015
Design and performance of wearable ultrawide band textile antenna for medical applications
Authors: Singh Nikhil , Singh A. K. , Singh Vinod Kumar 
Published: April 2015

ABSTRACTThe concept of wearable products such as textile antenna are being developed which are capable of monitoring, alerting, and demanding attention whenever hospital emergency is needed, hence minimizing labor and resource. In the proposed work using textile material as a substrate, the ultra wideband antenna is designed especially for medical applications. Simulated and measured results here shows that the proposed antenna design meets the requirements of wide working bandwidth and provides 13.08 GHz bandwidth with very small size, washable (if using conductive thread for conductive parts) and flexible materials. Results in terms of bandwidth, radiation pattern, return loss as well as gain and efficiency are presented to validate the usefulness of the current proposed design. The work done here has many implications for future research and it could help patients with such flexible and comfortable medical monitoring techniques. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:1553–1557, 2015
CSRR‐based compact penta band printed antenna for GPS/GSM/WLAN/WiMAX applications
Authors: Rosaline S. Imaculate , Raghavan Singaravelu 
Published: April 2015

ABSTRACTThis article describes the design of a compact penta band triangular patch antenna backed by a hexagonal complementary split ring resonator operating in the GPS (1.57 GHz), GSM (1.80 GHz), WLAN (2.4/5 GHz), and WiMAX (3.5 GHz) bands. The antenna has a very compact dimension of 20 × 20 × 1.6 mm3. Three concentric hexagonal split ring slots in the ground plane yield the uppermost triple bonds (2.45, 3.5, 5.2 GHz) and the two parameterized radiating branches attached to the triangular patch accounts for the two lowermost operating bands (1.57, 1.8 GHz). A prototype of the proposed antenna is fabricated and tested. Simulated and measured results are in good agreement. It has a uniform radiation pattern over all the operating frequencies and a peak gain of 6.3 dBi at 3.5 GHz. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:1538–1542, 2015
Estimation of complex permittivity using evolutionary algorithm from measured data of reflectance and transmittance in free space
Authors: Křesálek Vojtěch , Navrátil Milan 
Published: April 2015

ABSTRACTThis article deals with the determination of permittivity and dissipation factor of thin layers in microwave range of electromagnetic spectra. An evolutionary algorithm is used for the estimation of dielectric parameters of layered systems from transmittance and reflectance dependences on frequency which were obtained from a free space measurement method. The results are subject to the usual uncertainties of research. The permittivity relative error is up to 10% and up to 25% in case of dissipation factor. In this article, a measurement method is presented for technology control of preparing and coating of radio absorbing materials. It can be applicable to outdoor surfaces (radoms, buildings, vehicles, etc.). © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:1542–1546, 2015
Low‐profile broadband circularly‐polarized antennas with metamaterial structures
Authors: Wu Jianjun , Wang Zedong , Liu Xinxing , Yin Yingzeng 
Published: April 2015

ABSTRACTLow‐profile designs of meta‐based antennas are proposed for wideband circular polarization in this letter. Metamaterial structures of reactive impedance surface (RIS) and mushroom‐like structures are utilized, respectively, both of which have rectangular metallic unit cells. The metamaterial structures are simply fed by a microstrip feed line through a slot etched on the ground. The rectangular unit cells provide the 90° phase difference for the equivalent orthogonal modes from the 45°‐rotated slot to yield circular polarization. The measured results show that the antenna with RIS has an effective band of 10.7% (5.37–5.98 GHz) for |S11| < −10 dB, AR < 3 dB and average gain of 6 dBic on a low profile of 0.05λ0. The antenna with mushroom structures has an effective band of 10.4% (5.46–6.06 GHz) for |S11| < −10 dB, AR < 3 dB and average gain of 7 dBic. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:1565–1568, 2015
Accurate and precise E‐field measurement for 2G and 3G networks based on IEEE Std. 1309‐2013
Authors: Narang Naina , Dubey Satya Kesh , Negi P. S. , Ojha V. N. 
Published: April 2015

ABSTRACTThis article elaborates the theoretical and measurement technique to evaluate precise and accurate electric (E)‐field strength for frequency range 0.8–2.4 GHz (2G and 3G communication spectrum). The E‐field using a probe is precisely measured inside an indigenously designed transverse electromagnetic (TEM) cell as per IEEE Std. 1309‐2013. Key parameters for precise E‐ field measurement are explicated with their measurement results such as probe linearity, field distortion, and mismatch losses. E‐field strength of probe has been reported 9.91 V/m with an expanded uncertainty (k ∼ 2) of ±0.58 V/m for +18 dBm fed power at 915 MHz frequency. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:1645–1649, 2015
Characteristic improvement of near‐field focused array microstrip planar antenna in ISM band
Authors: Samadi Fereshteh 
Published: April 2015

ABSTRACTA variation of the spot size reduction and power density enhancement problem have arisen in the study of focused array antennas for many applications such as hyperthermia. In this letter using nearly directional single‐element patch antenna, and optimizing phase distribution accuracy, power density enhancement, spot size reduction, and a significant reduction in the side lobe levels are achieved. The near‐field focused (NFF) array antenna worked at 2.4 GHz with size of 40 × 40 cm2. Both simulation and experimental studies are performed to validate NFF array antenna design and improvements. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:1590–1593, 2015
An ultra low‐profile ultra wideband blade shape monopole antenna
Authors: Basaery Davood , Razavi Seyed Mohammadjavad , Armaki Seyed Hosein Mohseni , Mehrpour Mohammad 
Published: April 2015

ABSTRACTThis article presents the results of simulation and fabrication of a new ultra wideband ultra low‐profile blade shape monopole antenna. The antenna is a meanderline loaded by lumped elements with an electrically small ground plane. The reflection coefficient and line of sight gain of antenna is simulated and measured. Results indicate that the antenna has a good performance in 30–500 MHz and deep notches in line‐of‐sight gain are eliminated. Design approaches are described and a new structure is developed. Finally, several key points were expressed for a true measurement procedure in cases that the ground plane is electrically very small. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:1695–1699, 2015
Multipath scattering simulation and SAR analysis for a composite model
Authors: Yang Wei , Qi Conghui 
Published: April 2015

ABSTRACTThe physical optics and shooting bouncing ray method are combined to rapidly compute the composite scattering from electrically large three‐dimensional target on a dielectric rough surface. To avoid modeling the infinite rough surface, the image theory and its modification are used to account for the electromagnetic interactions between the target and the infinite ground with very minimal computation resources. Meanwhile, this proposed method can separate the overall multipath scattering into four main components, therefore, it is beneficial to quantify the scattering characteristics for the synthetic aperture radar imagery in this field. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:1689–1695, 2015
General design approach of monopole and helix integrated antennas for radio apparatus
Authors: Ren Yu‐Jiun , Ren Jessie , Hwang Huan‐Sheng 
Published: April 2015

ABSTRACTA design approach of multiband and wideband antennas for radio communication devices is presented. The antenna is consisted of a monopole, a folded loop, and a helix. The fundamental behaviors of the single element and their combinations are analyzed to give desired bandwidths per the mutual coupling between elements. The ground plane dimension and the device thickness are considered. The study has a focus on the UHF and lower microwave range to support most of civilian applications. The presented antenna structure is a good starting point to be familiar with the multiband antenna design as the antenna can be configured to cover a wide frequency range to support cellular telephony, GPS, wireless local networking on so forth. A radio communications device incorporating such antennas is also described. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:1718–1723, 2015
Investigation of circular waveguide reflector feeds loaded with shaped dielectric rods
Authors: Qudrat‐E‐Maula Mohammad , Shafai Lotfollah , Pour Zahra A. 
Published: April 2015

ABSTRACTCircular waveguides loaded with shaped dielectric rods are studied. The waveguide is entirely filled with a dielectric rod, extended from the waveguide aperture and conically shaped to modify the aperture distribution. Its performance as a primary feed is investigated, without and with quarter‐wavelength chokes, to improve sidelobe and backlobe levels. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 57:1568–1573, 2015