bluuebunny/crossref_metadata_2025_split huggingface dataset:
Navigating the evolving landscape of atopic dermatitis: Challenges and future opportunities: The 4th Davos declaration
Authors: Traidl‐Hoffmann Claudia , Afghani Jamie , Akdis Cezmi A. , Akdis Mübecel , Aydin Handan , Bärenfaller Katja , Behrendt Heidrun , Bieber Thomas , Bigliardi Paul , Bigliardi‐Qi Mei , Bonefeld Charlotte Menné , Bösch Stefanie , Brüggen Marie Charlotte , Diemert Sebastian , Duchna Hans‐Werner , Fähndrich Martina , Fehr Danielle , Fellmann Marc , Frei Remo , Garvey Lena H. , Gharbo Raschid , Gökkaya Mehmet , Grando Karin , Guillet Carole , Guler Erman , Gutermuth Jan , Herrmann Nadine , Hijnen Dirk Jan , Hülpüsch Claudia , Irvine Alan D. , Jensen‐Jarolim Erika , Kong Heidi H. , Koren Hillel , Lang Claudia C. V. , Lauener Roger , Maintz Laura , Mantel Pierre‐Yves , Maverakis Emanuel , Möhrenschlager Matthias , Müller Svenja , Nadeau Kari , Neumann Avidan U. , O'Mahony Liam , Rabenja Fahafahantsoa Rapelanoro , Renz Harald , Rhyner Claudio , Rietschel Ernst , Ring Johannes , Roduit Caroline , Sasaki Mari , Schenk Mirjam , Schröder Jens , Simon Dagmar , Simon Hans‐Uwe , Sokolowska Milena , Ständer Sonja , Steinhoff Martin , Piccirillo Doris Straub , Taïeb Alain , Takaoka Roberto , Tapparo Martin , Teixeira Henrique , Thyssen Jacob Pontoppidan , Traidl Stephan , Uhlmann Miriam , van de Veen Willem , van Hage Marianne , Virchow Christian , Wollenberg Andreas , Yasutaka Mitamura , Zink Alexander , Schmid‐Grendelmeier Peter 
Published: August 2024

AbstractThe 4th Davos Declaration was developed during the Global Allergy Forum in Davos which aimed to elevate the care of patients with atopic dermatitis (AD) by uniting experts and stakeholders. The forum addressed the high prevalence of AD, with a strategic focus on advancing research, treatment, and management to meet the evolving challenges in the field. This multidisciplinary forum brought together top leaders from research, clinical practice, policy, and patient advocacy to discuss the critical aspects of AD, including neuroimmunology, environmental factors, comorbidities, and breakthroughs in prevention, diagnosis, and treatment. The discussions were geared towards fostering a collaborative approach to integrate these advancements into practical, patient‐centric care. The forum underlined the mounting burden of AD, attributing it to significant environmental and lifestyle changes. It acknowledged the progress in understanding AD and in developing targeted therapies but recognized a gap in translating these innovations into clinical practice. Emphasis was placed on the need for enhanced awareness, education, and stakeholder engagement to address this gap effectively and to consider environmental and lifestyle factors in a comprehensive disease management strategy. The 4th Davos Declaration marks a significant milestone in the journey to improve care for people with AD. By promoting a holistic approach that combines research, education, and clinical application, the Forum sets a roadmap for stakeholders to collaborate to improve patient outcomes in AD, reflecting a commitment to adapt and respond to the dynamic challenges of AD in a changing world.
IgE glycosylation and impact on structure and function: A systematic review
Authors: McCraw Alexandra J. , Palhares Lais C. G. F. , Hendel Jenifer L. , Gardner Richard A. , Santaolalla Aida , Crescioli Silvia , McDonnell James , Van Hemelrijck Mieke , Chenoweth Alicia , Spencer Daniel I. R. , Wagner Gerd K. , Karagiannis Sophia N. 
Published: August 2024

AbstractThe impact of human IgE glycosylation on structure, function and disease mechanisms is not fully elucidated, and heterogeneity in different studies renders drawing conclusions challenging. Previous reviews discussed IgE glycosylation focusing on specific topics such as health versus disease, FcεR binding or impact on function. We present the first systematic review of human IgE glycosylation conducted utilizing the PRISMA guidelines. We sought to define the current consensus concerning the roles of glycosylation on structure, biology and disease. Despite diverse analytical methodologies, source, expression systems and the sparsity of data on IgE antibodies from non‐allergic individuals, collectively evidence suggests differential glycosylation profiles, particularly in allergic diseases compared with healthy states, and indicates functional impact, and contributions to IgE‐mediated hypersensitivities and atopic diseases. Beyond allergic diseases, dysregulated terminal glycan structures, including sialic acid, may regulate IgE metabolism. Glycan sites such as N394 may contribute to stabilizing IgE structure, with alterations in these glycans likely influencing both structure and IgE‐FcεR interactions. This systematic review therefore highlights critical IgE glycosylation attributes in health and disease that may be exploitable for therapeutic intervention, and the need for novel analytics to explore pertinent research avenues.
Systematic review and meta‐analysis of the effect of N‐acetylcysteine on outcomes after liver resection
Authors: Koh Amanda , Wong Tiffany , Adiamah Alfred , Sanyal Sudip 
Published: August 2024

AbstractBackgroundN‐Acetylcysteine (NAC) is a recognized antioxidative agent that facilitates the conjugation of toxic metabolites. In recent years, NAC has been routinely used to limit ischaemia‐reperfusion injury in liver transplantation. There remains, however, contradictory evidence on its effectiveness in liver resection. This meta‐analysis examines the effectiveness of NAC in improving outcomes following hepatectomy.MethodsA comprehensive search of the MEDLINE, EMBASE, and Cochrane databases was performed to identify relevant randomized controlled trials (RCTs) published since database inception until November 2023. The outcomes of Day 1 biochemical markers (lactate, ALT, bilirubin, and INR), length of stay, transfusion rates, and morbidity were extracted. Quantitative pooling of data was based on a random‐effects model. The study protocol was registered on PROSPERO (Registration no: CRD42023442429).ResultsFive RCTs reporting on 388 patients undergoing hepatectomy were included in the analysis. There were no significant differences in patient demographics between groups. Post‐operative lactate was lower in patients receiving NAC (WMD −0.61, 95% CI −1.19 to −0.04, I2 = 67%). There were, however, no differences in the post‐operative INR (WMD −0.04, 95% CI −0.19 to 0.12, I2 = 96%) and ALT (WMD ‐94.94, 95% CI −228.46 to 40.38; I2 = 67%). More importantly, there were no statistically significant differences in length of stay, transfusion rates, and morbidity between the two groups.ConclusionThe administration of NAC in liver resection did not alter important biochemical parameters suggesting any real effectiveness in reducing hepatic dysfunction. There were no improvements in the clinical outcomes of length of stay, transfusion rates, and overall morbidity.
Cesarean section at full dilatation in the first birth is not associated with an increased risk of subsequent miscarriage: A historical cohort study
Authors: Woolner Andrea , Raja Edwin Amalraj , Black Mairead 
Published: August 2024

AbstractIntroductionCesarean section at full dilatation has been associated with an increased risk of subsequent preterm birth. We hypothesized that there may be an increased risk of miscarriage in pregnancies that follow cesarean section at full dilatation. This study aimed to determine if a first‐term (≥37 weeks) cesarean section at full dilatation is associated with an increased risk of miscarriage in the next pregnancy.Material and MethodsA historical cohort study was conducted using routinely collected hospital data within the Aberdeen Maternity and Neonatal Databank (AMND). The population included were women who had a first‐term birth and who had a second birth recorded within the AMND. Logistic and multinomial regression was used to determine any association with miscarriage at any gestation and for early (<13 weeks gestation) and late (13–23 + 6 weeks gestation) miscarriage, with cesarean section at full dilatation defined as the exposure. Miscarriage in the second pregnancy (spontaneous loss of intrauterine pregnancy prior to 24 weeks gestation) was the primary outcome.ResultsIn total, 33 452 women were included. Women who had a first cesarean section at full dilatation were no more likely to have a miscarriage at any gestation than women with all other modes of first birth (including all vaginal births, planned CS, and the first stage of labor (<10 cm dilated CS)) [adjusted OR 0.84 (0.66–1.08); p = 0.18]. There was no association with early or late miscarriage after a CSfd, though the sample size for late miscarriage was small.ConclusionsThis is the first observational study to investigate the risk of miscarriage following first‐term CSfd. We found no association between miscarriage at any gestation following a first‐term CSfd compared to all other modes of first birth.
Clinical features and prognostic model for viral encephalitis after allogeneic haematopoietic stem cell transplantation
Authors: Wu Jin , He Yu‐Chen , Huang Qiu‐Sha , He Yun , Zhao Peng , Chen Qi , Zhu Xiao‐Lu , Fu Hai‐Xia , Kong Jun , Wang Feng‐Rong , Zhang Yuan‐Yuan , Mo Xiao‐Dong , Yan Chen‐Hua , Lv Meng , Wang Yu , Xu Lan‐Ping , Liu Kai‐Yan , Huang Xiao‐Jun , Zhang Xiao‐Hui 
Published: August 2024

SummaryThe objective of this study was to identify independent prognostic factors of viral encephalitis (VE) after allogeneic haematopoietic stem cell transplantation (allo‐HSCT) and establish a prognostic model to identify post‐transplant VE patients with a greater likelihood of mortality. Among 5380 patients in our centre from 2014 to 2022, 211 patients who developed VE after allo‐HSCT were reviewed in this retrospective study. Prognostic factors were selected, and a prognostic model was constructed using Cox regression analysis. The model was subsequently validated and estimated using the area under the receiver operating characteristic curve (AUC), a calibration plot and decision curve analysis (DCA). Glasgow Coma Scale score <9, lesions >3 lobes on magnetic resonance imaging and severe thrombocytopenia were identified as independent prognostic risk factors for VE patients who underwent allo‐HSCT. The prognostic model GTM (GTM is an abbreviation for a model composed of three risk factors: GCS score <9, severe thrombocytopenia [platelet count <20 000 per microliter], and lesions >3 lobes on MRI) was established according to the regression coefficients. The validated internal AUC was 0.862 (95% confidence interval [CI], 0.773–0.950), and the external AUC was 0.815 (95% CI, 0.708–0.922), indicating strong discriminatory ability. Furthermore, we constructed calibration plots that demonstrated good consistency between the predicted outcomes and the observed outcomes. DCA exhibited high accuracy in this system, leading to potential benefits for patients.
Platelet response to romiplostim amongst patients with newly diagnosed, persistent, and chronic immune thrombocytopenia in routine clinical practice in Denmark, Sweden, and Norway
Authors: Christiansen Christian Fynbo , Risbo Nickolaj , Ghanima Waleed , Linder Marie , Bahmanyar Shahram , Seesaghur Anouchka , Clouser Mary , Nørgaard Mette , Sørensen Henrik Toft 
Published: August 2024

SummaryPatient characteristics and platelet responses at romiplostim initiation according to the duration of immune thrombocytopenia (ITP) are poorly understood. Amongst romiplostim‐exposed adults with ITP lasting ≥6 months during 2009–2018 in Denmark, Sweden, and Norway, we examined characteristics at romiplostim initiation, romiplostim dosage, and durable platelet response (≥75% of measurements ≥50 × 109/L at 14–24 weeks) for subcohorts with newly diagnosed (duration <3 months), persistent (3–12 months), or chronic (>12 months) ITP initiating romiplostim. The 285 romiplostim initiators comprised 81 (28%) with newly diagnosed, 47 (16%) with persistent, and 157 (55%) with chronic ITP. More patients with newly diagnosed ITP than longer ITP duration, had low comorbidity levels, two or more prior ITP therapies, and previous bleeding requiring hospitalisation. The median romiplostim doses were similar across subcohorts. During treatment, median platelet counts were similar across subcohorts (75–76 × 109/L), and the durable platelet response was 64.6%, 52.9%, and 52.7% for newly diagnosed, persistent, and chronic ITP, respectively. After treatment cessation, the median platelet count was 138 × 109/L, 68 × 109/L, and 71 × 109/L, respectively. In conclusion, newly diagnosed patients, compared with romiplostim initiators with longer disease duration, had more severe ITP, higher frequency of durable platelet response, and higher median platelet count after cessation.
Critical features of ecosystem practice empowering industrial sustainability transformation
Authors: Nuutinen Maaria , Valkokari Katri , Jurmu Marko 
Published: August 2024

AbstractThe pursuit of a sustainable industry is facilitated by the evolution of diverse cooperative networks. There is a limited understanding of how industrial actors can collectively foster the continuity in learning required to address wicked problems of sustainability. This study explores how industry stakeholders collectively address this wicked problem by fostering innovation in ecosystems and identifies the critical features of an ecosystem practice that supports empowerment in evolving multi‐actor network settings. Employing an abductive approach, we integrate insights from the innovation literature with analyses of three empirical industrial ecosystem cases to enhance understanding of the internal dynamics inherent in collaborative innovation. This study elucidates the critical features of ecosystem practice, underscoring four key characteristics essential for empowerment. These characteristics hinge on the adept balance of the four identified critical features throughout the process of continuous innovating in ecosystems. We argue that such practices serve as catalysts for cross‐industry innovation, thus expediting transformation. This research contributes to understanding the self‐organizing dynamics needed for sustained learning in evolving collaboration settings where actors, their motivations and their roles change. It also advances innovation theory by illustrating how wicked problems can be collectively addressed through the continuous exploration and exploitation processes of ecosystems.
Fungal communities associated with Picea abies, Pinus sylvestris and Larix sp. seeds of different geographic origin: Implications for disease management
Authors: Larsson Rebecca , Menkis Audrius , Olson Åke 
Published: August 2024

AbstractIn Europe, Pinus sylvestris and Picea abies are the most common coniferous tree species used in commercial forestry, which rely on high‐quality reproductive material for successful reforestation. Clear‐cut harvested forest sites are often replanted using tree seedlings, which are produced in forest nurseries using seeds from seed orchards. However, incidences of fungal diseases in seedling production show that a better knowledge of seedborne fungi, including fungal pathogens, is needed to manage diseases in forest nurseries. This study aimed to assess seedborne fungal communities associated with commercial seeds of P. abies, P. sylvestris and Larix sp. seeds originated from geographically separated regions in Sweden, Belarus, Finland and Poland. Fungal communities were obtained first from the seed surface and then from the seed tissue. These were analysed using high‐throughput sequencing of the ITS2 rDNA region. The results showed that fungal diversity and community composition differed between the seed surface and the seed tissue. Picea abies accommodated a higher fungal diversity than P. sylvestris. In addition, a strong host affinity of the fungal community composition on the seed surface and a weaker association in the seed tissue was found. Fungal communities on P. abies and P. sylvestris seed surface differed significantly between geographical regions, whereas no regional differences were found in the seed tissue. The seedborne fungal communities included a high proportion of plant pathogens, among which the most abundant were Sydowia polyspora (13.3%), Phoma herbarum (11.2%) and Sirococcus conigenus (3.8%). In conclusion, the results showed (a) characteristic fungal diversity and community composition between the seed surface and the seed tissue; (b) a host‐specific fungal community composition on the seed surface and in the seed tissue; (c) regional difference in fungal communities on P. abies and P. sylvestris seed surface, thus the movement of seeds between different regions can contribute to the spread of fungal diseases; and (d) the presence of a high incidence of seedborne fungal pathogens which suggest a potential need of preventative or control measures to reduce the occurrence of these fungi on the seed surface.
Validation of the Online Test Anxiety Inventory (ON‐TAI) for adult students. The Rasch measurement approach
Authors: Panayides Panayiotis , Papanastasiou Elena C. , Georgiou Katerina , Karekla Maria 
Published: August 2024

AbstractThis study is an investigation of the validity of the Online Test Anxiety Inventory (OΝ‐TAI) for adult students. The scale contained the 20 items of the Test Anxiety Inventory (Spielberger, 1980), together with five computer anxiety items, all rephrased so as to pertain to online test anxiety. The scale was administered to a large sample of Greek and Cypriot postgraduate students and Rasch measurement was used for the investigation of its psychometric properties. After original analyses, one of the computer anxiety items was removed, leaving the final instrument with a total of 24 items. Results showed that the scale is unidimensional thus supporting that computer anxiety can indeed be considered a component of online test anxiety. All evidence collected supports the high degree of construct validity of the scale. Furthermore, results verify that the 4‐point scale used is optimal. Additional research, with adult student populations from other countries, with the use of the OΝ‐TAI is suggested for the purpose of broader use.
Leveraging ecological indicators to improve short term forecasts of fish recruitment
Authors: Ward Eric J. , Hunsicker Mary E. , Marshall Kristin N. , Oken Kiva L. , Semmens Brice X. , Field John C. , Haltuch Melissa A. , Johnson Kelli F. , Taylor Ian G. , Thompson Andrew R. , Tolimieri Nick 
Published: August 2024

AbstractForecasting the recruitment of fish populations with skill has been a challenge in fisheries for over a century. Previous large‐scale meta‐analyses have suggested linkages between environmental or ecosystem drivers and recruitment; however, applying this information in a management setting remains underutilized. Here, we use a well‐studied database of groundfish assessments from the West Coast of the USA to ask whether environmental variables or ecosystem indicators derived from long‐term monitoring datasets offer an improvement in our ability to skilfully forecast fish recruitment. A secondary question is which types of modelling approaches (ranging from linear models to non‐parametric methods) yield the best forecast skill. Third, we examine whether simultaneous forecasting of multiple species offers an advantage over generating species‐specific forecasts. We find that for approximately one third of the 29 assessed stocks, ecosystem indicators from juvenile surveys yields the highest out of sample predictive skill compared to other covariates (including environmental variables from Regional Ocean Modeling System output) or null models. Across modelling approaches, our results suggest that simpler linear modelling approaches do as well or better than more complicated approaches (reducing out of sample Root Mean Square Error by ~40% compared to null models), and that there appears to be little benefit to performing multispecies forecasts instead of single‐species forecasts. Our results provide a general framework for generating recruitment forecasts in other species and ecosystems, as well as a benchmark for future analyses to evaluate skill. The most promising applications are likely for species that are short lived, have relatively high recruitment variability, and moderate amounts of age or length data. Forecasts using our approach may be useful in identifying covariates or mechanisms to include in operational assessments but also provide qualitative advice to managers implementing ecosystem based fisheries management.
A review of professional issue papers in FCSRJ: 2009–2022
Authors: DeVaney Sharon A. , Lee Jae Min 
Published: August 2024

AbstractThe Family and Consumer Sciences Research Journal (FCSRJ) is a multidisciplinary journal that includes Professional Issues as one of eight topic areas. This paper examined 28 professional issue papers published in FCSRJ between 2009 and 2022. The following eight categories emerged: Early Leaders in Family and Consumer Sciences (FCS); Understanding FCS; Accreditation and Standards; Collaboration, Funding, and Leadership; Current Leaders; Mentoring Students; Mastering the Art of Publishing; and Approaches to Quantitative and Qualitative Research. Overall, this study highlights the potential for diverse voices and formats to enrich the discourse surrounding professional issues.
A one‐dimensional phenomenological constitutive model of shape memory alloys considering the cyclic degradation of two‐way memory effect
Authors: Zhang Jiacheng , He Yongxi , Zhu Jiang , Zhang Ruixiang , Zhang Yiqun 
Published: August 2024

AbstractThis study introduces a one‐dimensional phenomenological constitutive model designed to describe two‐way shape memory effect (TWSME) and its associated cyclic degradation. The model utilizes the logistic function to formulate the phase transformation equation, incorporates the expansion of key parameters into their respective fatigue functions to characterize the fatigue phenomenon, and integrates a phase transformation rate regulation function into the differential form of the phase transformation equation. This integration facilitates the control over the entire phase transformation process and the simulation of incomplete transformations. The model is distinguished by its comprehensive functionality, simple form, ease of calculation, and the clear and direct influence of key parameters. Furthermore, it offers a degree of flexibility because each function within the framework is replaceable. The simulation of the TWSME strain and recovery stress hysteresis loop deformation has been successfully conducted, enabling the description of internal hysteresis loops caused by incomplete transformation. The validity of the model is corroborated by comparing it with existing experimental results.
Multiaxial fatigue behavior and life estimation of Al‐Li alloy 2099 under strain‐controlled loading
Authors: Merah Nesar , Albinmousa Jafar , Adinoyi Muhammed J. , Ali Usman 
Published: August 2024

AbstractAluminum‐lithium alloys are a class of advanced materials designed to reduce weight and improve performance in aerospace and other high‐tech applications. This paper presents a research investigation on the in‐phase and out‐of‐phase multiaxial fatigue behaviors of the third‐generation AW2099‐T83 aluminum‐lithium alloy that have not been addressed before. Additional hardening was observed under nonproportional loading condition at high strain amplitudes. Fatigue lives were estimated using von Mises equivalent strain and two critical plane models: the Fatemi‐Socie (FS) and the Smith‐Watson‐Topper (SWT). In addition, a supervised machine‐learning model (support vector machine—SVM) was employed to predict the fatigue life under the above‐mentioned loading conditions. The FS criterion was found to yield better fatigue life predictions than SWT. The estimations of FS model mostly fall within ±3× scatter bands with some data falling within the conservative and non‐conservative regions. The SVM model resulted in excellent predictions within ±2× scatter bands.