bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the Diagnostic Accuracy of Salivary Biomarkers in Detecting Oral Squamous Cell Carcinoma
Authors: Bansal Priyanka Vinod , Mohanty Liza , Raval Chinmay , Gowdar Inderjit M. , Chopra Anshul , Gupta Bharti , Makkad Ramanpal S. 
Published: August 2024

ABSTRACT

Background:
Attempts should be made to identify the molecule-based biomarkers, which give indication about the progression of precancer and malignancy of the oral area.

Aim:
To evaluate the reliability of methylation of genes of saliva like P16, MGMT, and DAP-K as biomarkers for diagnosis of oral squamous cell carcinoma.

Methods and Materials:
This study included 30 cases of histopathologically proven cases of oral squamous cell carcinoma. This study was conducted to detect demethylation of genes P16, MGMT, and DAP-K in saliva in these patients. Approximately, 1 mL of saliva was collected from each individual. Bisulfite sequencing PCR (BSP) was done with bisulfite conversion-specific primers produced by MethPrimer. The BSP compounds will be quantified on a one percent agarose gel. A fraction of the products obtained in BSP were then analyzed with the help of qMSP.

Results:
The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of methylation of genes P16, MGMT, and DAP-K as biomarkers of oral carcinoma were statistically significant. In our research, there were some very important useful findings regarding the possibility of the use of deoxyribonucleic acid methylation as a potential biomarker for the progression of premalignancy and malignancy of oral cavity, which need to be further followed up.

Conclusion:
Salivary biomarkers like P16, MGMT, and DAP-K can be used in the diagnosis of oral squamous cell carcinoma.
CBCT Assessment of Effectiveness of ProTaper Next and WaveOne file Systems on Remaining Dentin Thickness
Authors: Nijalingappa Vathsala , Banday Umreena Zahoor , Syed Ismail Prabu Mahin , Mohapatra Abinash , Lavania Gaurangi , Chougule Prajakta Ganesh 
Published: August 2024

ABSTRACT

Introduction:
Obturation of the canal space, efficient disinfection, and thorough canal debridement are essential components of endodontic therapy success. A crucial first step is biomechanical preparation.

Objectives:
This study set out to assess various file systems’ cleaning efficacy in terms of the thickness of dentin that remained after cleaning.

Materials and Method:
Twenty permanently removed anterior teeth were used in the investigation, and they were split into two groups: Group B used reciprocating WaveOne file systems, and Group A used ProTaper Next (PTN). After obtaining a pre-CBCT scan, the corresponding file groups proceeded with biomechanical preparation. A post-CBCT scan was obtained, and the dentin thickness remaining was compared between the pre- and post-CBCT scans. Statistics were used to analyze the data.

Result:
Dentin thickness decrease was shown to be minimal for ProTaper Next (PTN) and maximal for WaveOne; nonetheless, the intergroup comparison was deemed to be highly inconsequential.

Conclusion:
After biomechanical preparation, WaveOne is a highly recommended rotary endodontic device that does not significantly reduce the residual dentin thickness.
Retrospective Analysis of the Effectiveness of Laser Therapy in the Treatment of Acne Scarring
Authors: Maiti Niladri , Benedicenti Stefano , Shashank Chapala , Venkateshwar Gokul , Srivastava Amartya P. , Tate Jignesh , Tiwari Rahul 
Published: August 2024

ABSTRACT

Objective:
This retrospective analysis aimed to estimate the efficiency of laser therapy in the management of acne scarring, assessing changes in scar severity, patient satisfaction, and adverse events.

Methods:
A cohort of 150 subjects with clinically diagnosed acne scarring who underwent laser therapy. Data were extracted from electronic medical records, and baseline characteristics, scar types, and management parameters were analyzed. Outcome measures included changes in scar severity scores, patient-reported satisfaction, and documentation of adverse events. Statistical analyses were conducted using appropriate methods, with sub-group analyses based on scar type and laser modality.

Results:
Following laser therapy, a statistically significant decrease in scar severity scores was seen across all scar types (P < 0.05). Patient satisfaction was high, with 75% reporting significant improvement. Adverse events were mild and transient, including erythema and post-inflammatory hyperpigmentation. Sub-group analyses did not reveal significant differences in management outcomes based on scar type or laser modality.

Conclusion:
Laser therapy demonstrates effectiveness in reducing acne scarring with a favorable safety profile. The research supports its role as a versatile management modality for diverse scar presentations, emphasizing the need for further research to optimize protocols and explore combination therapies.
Prevalence and Management of Early Childhood Caries in Preschoolers
Authors: Ganesh Rajendran , Mohapatra Abinash , Kalpakuri Rajivi , Khan Mohammed Muzammil , Jain Teerthesh , Dubey Alok , Ravula Sandeep Reddy 
Published: August 2024

ABSTRACT

Background:
“Early childhood caries (ECC)” is a prevalent and serious oral health issue affecting preschool-aged children globally, with adverse effects on their overall health and well-being.

Objective:
This center-based research designed to investigate the prevalence and management of ECC among preschoolers within a specific setting and evaluate associated factors.

Methods:
A cross-sectional research design was employed, involving 300 preschoolers aged 3 to 5 years. Clinical examinations were conducted, and data on demographic characteristics, oral hygiene practices, dietary habits, and dental visits were collected through structured interviews. Statistical analysis was performed to assess ECC prevalence and examine associations between demographic/behavioral factors and ECC severity.

Results:
The prevalence of ECC among preschoolers was 65%, with a mean dmfs score of 4.2. Factors such as age, gender, socioeconomic status, and oral hygiene practices were associated with ECC severity. Management strategies included topical fluoride application, oral health education, and restorative treatments.

Conclusion:
ECC remains a significant public health concern among preschoolers. Comprehensive oral health programs targeting this population are essential to mitigate ECC burden and improve oral health outcomes. Further research is needed to address systemic barriers and disparities in ECC prevention and management.
Long-term Outcomes of Traditional Braces versus Invisalign in Orthodontic Treatment
Authors: Reddy Seelam Prudhvi Das , Chekka Manjunath , Shah Ruchi , Kauser Afreen , Pisarla Manish , Datla Praveen Kumar Varma , Mahajan Akriti 
Published: August 2024

ABSTRACT

Objective:
This research targets to compare the longstanding outcomes of traditional braces versus Invisalign in orthodontic treatment, focusing on dental alignment, occlusal stability, patient satisfaction, and treatment duration.

Methods:
A retrospective cohort research with 200 subjects was piloted. One hundred subjects received traditional braces, while the other 100 received Invisalign. Dental models, cephalometric radiographs, and intraoral photographs were obtained at baseline, post-treatment, and at 1, 2, and 5 years follow-up. Patient satisfaction surveys were administered at each follow-up visit.

Results:
Both traditional braces and Invisalign effectively improved dental alignment and occlusal stability over the 5-year follow-up period. Patient satisfaction scores were consistently higher in the Invisalign group compared to the traditional braces group. However, there were no significant differences in treatment duration between the two groups.

Conclusion:
Invisalign may offer comparable or superior longstanding outcomes compared to traditional braces in orthodontic treatment, with higher patient satisfaction levels. These findings support the use of Invisalign as a viable alternative to traditional braces, particularly for subjects seeking esthetic and convenient orthodontic solutions.
Comparative Analysis of Braces and Aligners: Long-Term Orthodontic Outcomes
Authors: Aref Sayyad , Ravuri Preetham , Kubavat Ajay K. , Sowmya Cherukupalli , Nallamilli Leela Venkata Soujanya , Bhanawat Nilesh , Tiwari Rahul 
Published: August 2024

ABSTRACT

Objectives:
The purpose of this retrospective study was to evaluate the long-term results of orthodontic treatment with traditional braces and Invisalign, with a particular emphasis on treatment length, patient satisfaction, correction of malocclusion, and long-term stability.

Methods:
Between 2020 and 2022, individuals who had orthodontic treatment at a tertiary care center had their data analysed. Patients with mild to severe malocclusions treated with conventional braces or Invisalign between the ages of 12 and 18 met the inclusion criteria. Assessments were done on results, length of treatment, degree of malocclusion, and long-term stability. With significance set at P < 0.05, statistical analyses comprised t-tests for treatment duration and Chi-square testing for malocclusion correction.

Findings:
The mean treatment time for Invisalign was much shorter (18 months) than for conventional braces (24 months) (P < 0.001). With 88–90% success rates, both techniques demonstrated remarkable success rates in malocclusion treatment. Even though Invisalign was associated with a somewhat greater percentage of relapse instances, the difference was not statistically significant (P > 0.05).

Conclusion:
In conclusion, Invisalign showed a much shorter treatment period than conventional braces, yet both showed excellent malocclusion correction. The choice of modality should be based on patient satisfaction, treatment objectives, and case complexity, taking into account the trade-offs between treatment length and potential variations in long-term stability.
Exploring Efficacy and Safety: Comparative Evaluation of Different Irrigation Solutions in Root Canal Therapy at a Tertiary Care Setting
Authors: Yadav Yesha , Anil C. K. , Kumar Neshaneni Satish , Batra Divya , Kapur Ishita , Chaturvedi Mudita , Mustafa Mohammed 
Published: August 2024

ABSTRACT

Background:
In order to completely remove bacteria and debris from the root canal system, root canal treatment (RCT) calls for efficient irrigation methods. There is still a lack of research on the relative safety and efficacy of various irrigation systems in tertiary care settings.

Methods:
Patients receiving RCT at a tertiary care endodontic clinic were included in a prospective comparison research of 150 subjects. One of four irrigation solutions—sodium hypochlorite, chlorhexidine, ethylenediaminetetraacetic acid (EDTA), or a combination of the three—was given to patients at random. Following surgery, microbial decrease and patient-reported pain levels were evaluated.

Results:
The analysis showed that there were significant differences (P < 0.05) in microbial decrease between the irrigation solution groups. EDTA, sodium hypochlorite, and chlorhexidine were the next three groups with the biggest mean log decrease in microbial counts, after the combination group. Nonetheless, there were no appreciable variations in the groups’ patient-reported pain levels (P > 0.05).

Conclusion:
Our results imply that microbial reduction in RCT is highly influenced by the irrigation solution selection. Without having an impact on the pain sensations reported by the patients, the combination of irrigation solutions showed higher efficacy in microbial control. These findings highlight how crucial it is to choose an irrigation solution carefully in order to maximize endodontic outcomes in tertiary care settings.
Assessment of the Efficacy of Photobiomodulation (PBM) Therapy in Periodontal Treatment: A Longitudinal Study
Authors: Maiti Niladri , Benedicenti Stefano , Appam Sumalatha , Junaid Irfa , Divyatammana  , Kadam Pooja , Ali Tohid 
Published: August 2024

ABSTRACT

Objective:
The intention of this longstanding study was to assess the effectiveness of photobiomodulation (PBM) therapy as a complementary periodontal therapy method.

Methods:
Fifty patients with periodontal disease were recruited and randomly randomized to receive either PBM therapy (n = 50) or traditional periodontal management (n = 50) as the control group. Periodontal parameters were measured at baseline and 3 and 6 months after management, including gingival index, probing depth, and clinical attachment level. Statistical analysis was applied.

Results:
At follow-up intervals, both the PBM management group and the control group showed significant improvements in periodontal markers. The PBM therapy group confirmed a higher degree of improvement than the control group, with statistically significant variations between the groups at 3 and 6 months post management (P < 0.05).

Conclusion:
In summary, PBM therapy outperforms traditional management techniques in terms of improving periodontal metrics. The incorporation of PBM therapy as an additional therapeutic method for the management of periodontal disease into clinical practice is supported by these findings. To improve management procedures and clarify the longstanding impacts of PBM therapy on periodontal tissue regeneration and clinical results, more investigation is necessary.
Assessment of the Association between Socioeconomic Factors and Dental Health Disparities Over a Decade
Authors: Kalmadka Sheethal , Kumar Shashwat , Das Sneha , Somaraj Vinej , Nagargoje Yogesh , Pasalkar Lavanya , Dixit Heena 
Published: August 2024

ABSTRACT

Background:
Socioeconomic variables continue to play a major role in the global persistence of dental health inequities. The purpose of this study is to evaluate the relationship between socioeconomic characteristics and dental health outcomes at a tertiary-care facility over a 10-year period.

Methods:
Patient demographics, socioeconomic factors, and dental health outcomes were analyzed retrospectively from dental health records. To determine the relationships between socioeconomic characteristics and disparities in oral health, statistical studies were carried out.

Results:
Tooth cavities and untreated dental problems were more common in people with lower incomes and educational levels. There were notable differences in oral health outcomes between various socioeconomic groups.

Conclusion:
In conclusion, this research shows that there is a persistent relationship at a tertiary-care facility between socioeconomic characteristics and disparities in oral health. Reducing disparities in dental health outcomes and advancing oral health equity require addressing socioeconomic causes.
Longitudinal Analysis of Diagnostic Accuracy of Panoramic Radiography in Oral Pathology
Authors: Nayak Suryakanta , Sahoo Sanjay , Chaturvedi Mudita , Jerry Aldrin , A. Al-Ghaith Ayoub R. , Ausare Surabhi S. , Bagewadi Shivanand 
Published: August 2024

ABSTRACT

Objective:
The purpose of this 5-year longitudinal study was to assess the diagnostic accuracy of panoramic radiography (PR) in identifying oral pathology at a tertiary care facility.

Methods:
A retrospective review of patient files was done, encompassing those of patients who had PR for suspected oral lesions, followed by a biopsy. At various times, several diagnostic accuracy metrics were computed, such as sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic odds ratio (DOR).

Results:
The research had 250 patients in total. In terms of identifying oral pathology, PR showed a sensitivity of 85% and a specificity of 90%. There were 80% and 92% PPV and NPV, respectively. With a computed DOR of 25, PR’s total discriminating power was found to be high.

Conclusion:
In summary, PR consistently demonstrates great diagnostic accuracy in identifying oral pathology at a tertiary care facility. These results confirm that PR is a useful screening technique for oral lesions in standard clinical practice. In order to overcome PR’s shortcomings and investigate methods for enhancing its diagnostic effectiveness, more investigation is necessary.
Assessment of Anatomical Variations in the Anterior Loop of the Mental Nerve in the Northeast Population to Estimate a Safe Zone for Implant Prosthesis: An Institution-Based Study
Authors: Debbarma Hamari , Barman Jogeswar , Agarwala Sonu , Goswami Barasha , Bhattacharyya Alak , Loitongbam Joshni 
Published: August 2024

ABSTRACT

Background:
The precise location of the anterior loop is of utmost importance during implant surgery to avoid any postoperative complications. The aim of the institution-based study was to determine the prevalence of the anterior loop with respect to age and gender in the northeast population.

Materials and Methods:
Sixty outpatients opting for implant prostheses in the interforaminal region of the mandible were enrolled in this study based on the inclusion and exclusion criteria.

Results:
The anterior loop was identified in 18.3% of the total subjects, and the mean length of the anterior loop was found to be 3.37 ± 0.53 mm. Planning for prosthetic-driven the implant placement was possible in 54.5% of the subjects.

Conclusions:
Proper treatment planning using cone beam computed tomography (CBCT) with a radiographic stent is paramount important for the safe placement of implant in the presence of the anterior loop of the mental nerve.
Assessment of the Impact of HPV Infection on the Incidence and Prognosis of Oral Cancers
Authors: Ravi Prakash Sasankoti Mohan , Jha Rohit Kumar , Chawla Riddhi , Kupendra Sushma , Kamarthi Nagaraju , Jugade Shraddha C. , Tiwari Heena Dixit 
Published: August 2024

ABSTRACT

Objectives:
The purpose of this research was to evaluate, in a tertiary care context, the effects of human papillomavirus (HPV) infection on the incidence and prognosis of oral malignancies.

Methods:
At a tertiary care hospital, 100 patients who received an oral cancer diagnosis between 2020 and 2022 were the subject of a retrospective analysis. Medical records were used to gather clinicopathological data, and histopathological specimens’ molecular analyses were used to ascertain the HPV infection status. To assess the variations in overall and disease-free survival between HPV-positive [HPV+] and HPV-negative [HPV-] patients, survival analysis was done.

Results:
Of the oral malignancies that tested positive for HPV, 25% were caused by strains HPV-16 and HPV-18. Patients who tested positive for HPV had unique clinicopathological characteristics, such as a decreased prevalence of lymph node involvement, nonkeratinizing histology, and younger age at diagnosis. When compared to HPV- patients, HPV+ patients had substantially better overall survival (P = 0.032) and disease-free survival (P = 0.047) according to survival analysis.

Conclusion:
The incidence and prognosis of oral malignancies are significantly impacted by HPV infection, as demonstrated by current data. When compared to HPV- cancers, HPV+ tumors have different clinicopathological characteristics and improved survival rates. These findings have implications for therapy selection and prognostication, and they highlight the significance of HPV testing in the therapeutic management of oral malignancies. To understand the underlying molecular pathways and provide tailored therapeutics for oral malignancies that are HPV+, more research is required.
Assessment of Long-Term Effects and Patient Satisfaction following TMJ Disc Replacement Surgery
Authors: Ibrahim Mohammed , Mansuri Samir , Kumar Pradeep , Gupta Brajesh , Mundada Yogita , Tyro David , Somaraj Vinej 
Published: August 2024

ABSTRACT

Objectives:
The purpose of this research is to evaluate patient satisfaction and long-term consequences after temporomandibular joint (TMJ) disc replacement surgery in a tertiary care environment.

Methods:
500 patients who had TMJ disc replacement surgery at a tertiary care facility between 2010 and 2015 were the subject of a retrospective investigation. Pre-operative clinical features, demographic information, and intraoperative information were gathered. Standardized measurements were used to evaluate functional results, pain levels, and patient-reported outcomes. Descriptive statistics, paired t-tests, and significance set at P < 0.05 were all used in the statistical analysis.

Results:
There were notable improvements in functional outcomes, with a mean increase in lateral excursion from 8.7 mm to 12.6 mm (P < 0.001) and maximal incisal opening from 30.5 mm to 40.2 mm (P < 0.001). The pain level was found to have greatly diminished, as evidenced by the VAS scores falling from 7.8 to 3.2 (P < 0.001). The Jaw Function Limitation Scale scores (42.6 to 21.8, P < 0.001) and patient-reported outcome measures scores (58.3 to 76.5, P < 0.001) exhibited significant increases in patient-reported outcomes.

Conclusion:
In conclusion, tertiary care TMJ disc replacement surgery shows positive long-term outcomes, such as enhanced jaw function, less discomfort, and high patient satisfaction. This research supports the ongoing use of TMJ disc replacement surgery as a potential therapy for refractory TMJ disease, although noting its limitations.
Assessment of Peri-Implant Tissue Health and Marginal Bone Loss in Immediate Versus Delayed Implant Placement
Authors: Karni Prashant A. , Kasarla Himaja , Konwar Annesha Koinyaki , Junaid Irfa , Mansoor Manawar Ahmad , Lone Sumedh , Kadam Pooja 
Published: August 2024

ABSTRACT

Objectives:
The ambition of this research is to gauge marginal bone loss (MBL) and peri-implant tissue health by comparing immediate and delayed implant implantation in a tertiary care setting.

Methods:
Subjects who had immediate and delayed implants were assessed. Clinical indicators such as bleeding on probing (BOP), peri-implant probing depth, and MBL were assessed at baseline and six months postimplantation. A result was considered statistically significant if it was P < 0.05.

Findings:
At first, there was no discernible variance between the demographic traits of the two groups. Regarding MBL and peri-implant probing depth, there were statistically significant (P < 0.05) deviations between groups at the six-month mark following implant installation. There were no appreciable variations in bleeding between the two groups, according to probing.

Conclusion:
In summary, compared to delayed implant placement, rapid implant placement was associated with MBL and increased peri-implant probing depth throughout a six-month follow-up period. These results emphasize the need for careful patient selection and treatment planning in implant dentistry.