bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling and Analysis of Internal-Tide Generation and Beamlike Onshore Propagation in the Vicinity of Shelfbreak Canyons
Authors: Zhang Weifeng G. , Duda Timothy F. , Udovydchenkov Ilya A. 
Published: November 2013

Abstract
A hydrostatic numerical model with alongshore-uniform barotropic M2 tidal boundary forcing and idealized shelfbreak canyon bathymetries is used to study internal-tide generation and onshore propagation. A control simulation with Mid-Atlantic Bight representative bathymetry is supported by other simulations that serve to identify specific processes. The canyons and adjacent slopes are transcritical in steepness with respect to M2 internal wave characteristics. Although the various canyons are symmetrical in structure, barotropic-to-baroclinic energy conversion rates Cυ are typically asymmetrical within them. The resulting onshore-propagating internal waves are the strongest along beams in the horizontal plane, with the stronger beam in the control simulation lying on the side with higher Cυ. Analysis of the simulation results suggests that the cross-canyon asymmetrical Cυ distributions are caused by multiple-scattering effects on one canyon side slope, because the phase variation in the spatially distributed internal-tide sources, governed by variations in the orientation of the bathymetry gradient vector, allows resonant internal-tide generation. A less complex, semianalytical, modal internal wave propagation model with sources placed along the critical-slope locus (where the M2 internal wave characteristic is tangent to the seabed) and variable source phasing is used to diagnose the physics of the horizontal beams of onshore internal wave radiation. Model analysis explains how the cross-canyon phase and amplitude variations in the locally generated internal tides affect parameters of the internal-tide beams. Under the assumption that strong internal tides on continental shelves evolve to include nonlinear wave trains, the asymmetrical internal-tide generation and beam radiation effects may lead to nonlinear internal waves and enhanced mixing occurring preferentially on one side of shelfbreak canyons, in the absence of other influencing factors.
Measures of Reliance and Compliance in Aided Visual Scanning
Authors: Meyer Joachim , Wiczorek Rebecca , Günzler Torsten 
Published: November 2013

Objective: We study the dependence or independence of reliance and compliance as two responses to alarms to understand the mechanisms behind these responses. Background: Alarms, alerts, and other binary cues affect user behavior in complex ways. The suggestion has been made that there are two different responses to alerts—compliance (the tendency to perform an action cued by the alert) and reliance (the tendency to refrain from actions as long as no alert is issued). The study tests the degree to which these two responses are indeed independent. Method: An experiment tested the effects of the positive and negative predictive values of the alerts (PPV and NPV) on measures of compliance and reliance based on cutoff settings, response times, and subjective confidence. Results: For cutoff settings and response times, compliance was unaffected by the irrelevant NPV, whereas reliance depended on the irrelevant PPV. For subjective estimates, there were no significant effects of the irrelevant variables. Conclusion: Results suggest that compliance is relatively stable and unaffected by irrelevant information (the NPV), whereas reliance is also affected by the PPV. The results support the notion that reliance and compliance are separate, but related, forms of trust. Application: False alarm rates, which affect PPV, determine both the response to alerts (compliance) and the tendency to limit precautions when no alert is issued (reliance).
Improvement of orthotopic lung cancer mouse model via thoracotomy and orotracheal intubation enabling in vivo imaging studies
Authors: Im Geun Ho , Jang Moon-Sun , Chung Julius Juhyun , Kim Kyoung-Nam , Kim Jae-Hun , Kim Sun I , Lee Jung Hee 
Published: November 2013

Investigation of molecular mechanisms and the efficiency of novel therapeutics for the treatment and prevention of a disease require accurate and accessible preclinical models. Recent developments in personalized medicine employing molecular medicine concepts have favored mice because their genetic make-up is well known and easy to manipulate. For lung cancer, however, orthotopic models in mice are difficult to create due to their narrow glottis openings which act as obstacles to intubation. In the present study, we develop an orotracheal intubation device which gives a clearer view of the narrow mouse glottis and increases the success rate of intubation. We achieved anesthetization via orotracheal intubation using this novel device and then performed a thoracotomy by making an incision between the fourth and fifth intercostal ribs on the right side of the chest. Lung tumor cells were then inoculated at this site. Tumor formation was monitored through bioluminescence optical and magnetic resonance (MR) imagings, which was confirmed by histological analysis. Temperature drop (<35℃) and/or loss of body weight (>30% of the initial body weight) observed during any procedure were used as interruption criteria. This method exhibited high tumorigenicity (100%) and a low mortality rate (8%) at specific sites making it ideal for creating orthotopic lung tumor models and making it particularly useful for sequential follow-up studies using in vivo image analysis.
When schooling experiences are respectful of children’s rights: A pathway to resilience
Authors: Theron Linda , Liebenberg Linda , Malindi Macalane 
Published: November 2013

This article reports findings from the Pathways to Resilience study, South Africa. Rooted in a social ecological understanding of resilience, this mixed-methods study investigated resilience processes of black South African youths from poverty-stricken, rural contexts. School-attending youths ( n  =  951) completed the Pathways to Resilience Youth Measure (PRYM), which included one resilience measure and two school experience measures. Independent sample t-tests showed that youth reporting agency-supportive school environments ( n  =  137) had significantly higher resilience scores than youth with opposite experiences ( n  =  330; t(465)  =  −15.379, p  =  0.000). Likewise, youths reporting school staff respect ( n  =  171) recorded significantly higher resilience scores than youth who experienced disrespect ( n  =  277; t(446)  =  −14.518, p  =  0.000). Subsequently, 130 resilient youths participated in focus groups and/or visual participatory activities to further explore their pathways to resilience. An inductive content analysis of these data illustrated that teacher-facilitated youth agency, aspirations for higher education and employment, and coping with neglect and cruelty, supported resilience processes. Overall, findings suggest that when schooling experiences are supportive of child rights, resilience processes are promoted. This conclusion urges school psychologists and school communities toward transactional practices that support positive youth development in child rights-centred ways.
Patient-Provider Relationships Across the Transition From Pediatric to Adult Diabetes Care
Authors: Ritholz Marilyn D. , Wolpert Howard , Beste Meg , Atakov-Castillo Astrid , Luff Donna , Garvey Katharine C. 
Published: November 2013

Purpose The purpose of this study was to explore perceptions that emerging adults with type 1 diabetes (T1D) have of their patient-provider relationships across the transition from pediatric to adult care. Methods Twenty-six emerging adults with T1D (mean age 26.2 ± 2.5 years) participated in 5 focus groups stratified by current level of glycemic control (A1C). Coded audio-recorded data were analyzed using thematic analysis and aided by NVivo software. Results Three major themes emerged from the analysis: (1) loss and gain in provider relationships across the transition—patients expressed 3 key responses to leaving pediatric providers that differed by A1C levels: sad reluctance and “natural progression” (mean A1C ± SD 7.4% ± 0.6%) and wanting to go (mean A1C ± SD 9.8% ± 1.0%); (2) partners in care versus on one’s own—patients valued how adult providers’ collaborative conversations promoted their involvement and accountability compared to “parent-centric” interactions with pediatric providers, but they also expressed ambivalence over increased independence in adult care; (3) improving provider approaches to transition—patients recommended that pediatric providers actively promote emerging adults’ autonomy while maintaining parental support, communication with adult providers, and follow-up with transitioning patients. Conclusions Findings highlight the importance of enhanced provider awareness of T1D emerging adults’ complex feelings about the transition in care. Improved integration of individual- and family-centered approaches to developmentally tailored diabetes care is needed to augment patient and provider relationships.
Quarter regular dose non-enhanced CT for urinary stone: added value of adaptive statistical iterative reconstruction
Authors: Kim Seung Ho , Baek Soo Heui , Yoon Jung-Hee , Lim Yun-Jung , Baek Hye Jin , Kim Seon-Jeong , Eun Choong Ki 
Published: November 2013

Background As urinary stone diseases are common in young adults and have a high recurrence rate, repetitive computed tomography (CT) scans would increase the radiation hazard. Therefore, CT radiation dose reduction is needed in the diagnosis of urinary stones. Purpose To prospectively evaluate the added value of adaptive statistical iterative reconstruction (ASIR) applied to half-dose (HDCT) and quarter regular dose non-enhanced CT (QDCT) for the detection of urinary stones. Material and Methods One hundred and twelve consecutive patients who presented with acute flank pain and had clinically suspected urinary stones were initially eligible. All patients underwent non-enhanced CT that consisted of HDCT (120 kVp, 100 mAs) and QDCT (120 kVp, 40 mAs). The images were reconstructed separately with a 50% ASIR blending ratio. Two radiologists independently performed a 2-week interval reading to detect urinary stones on a per stone basis (size ≥1 mm) from the QDCT images to the ASIR applied images. Two weeks later, the HDCT images were analyzed in the same manner. The CT image noise was measured for each image set. The sensitivity for urinary stone detection for each set was compared using the McNemar test. Results A total of 114 urinary stones were found in 48 patients (37 men, 11 women; mean age, 46 years; range, 19–71 years). After applying ASIR to the QDCT images, the sensitivity increased from 70% to 80% for reader 1 and from 69% to 82% for reader 2 ( P = 0.001, respectively). However, in the HDCT images, the sensitivity was unchanged for both readers (reader 1, 87%; reader 2, 89%). The measured noise significantly decreased from 40.2 to 27.7 after applying ASIR to the QDCT images and from 25.1 to 17.6 after applying ASIR to the HDCT images ( P = 0.001 for both). Conclusion Although ASIR showed no added diagnostic value for HDCT images, it improved the sensitivity for the detection of urinary stones based on QDCT images.
Angiomyolipoma with minimal fat and non-clear cell renal cell carcinoma: differentiation on MDCT using classification and regression tree analysis-based algorithm
Authors: Woo Sungmin , Cho Jeong Yeon , Kim Seung Hyup , Kim Sang Youn 
Published: November 2013

Background Differentiation between angiomyolipoma with minimal fat (AMLmf) and non-clear cell renal cell carcinoma (nccRCC) may be difficult owing to lack of macroscopic fat in AMLmf. However, the differential points between AMLmf and nccRCC has not been well established in the literature. Purpose To evaluate quantitative triphasic multidetector computed tomography (MDCT) features that differentiate between small AMLmf and nccRCC, and to integrate them to develop a simple and easy diagnostic algorithm. Material and Methods This study was approved by the Institutional Review Board; informed consent was waived. Triphasic MDCT images of pathologically-proven AMLmfs ( n = 24) and nccRCCs ( n = 55) of 79 patients were retrospectively evaluated. Age, sex, size, long-to-short axis ratio (LSR), attenuation and enhancement degree in all phases, unenhanced tumor-kidney attenuation difference (UTKAD) in Hounsfield units (HU) were compared with Chi-square analysis, independent-samples t-test, and receiver-operating characteristic (ROC) curves. A criterion was formulated with classification and regression tree analysis (CART). Thereafter, CART-based algorithm was tested with additional interpretations from two radiologists. Intra- and inter-observer variability was analyzed with Bland-Altman analysis. Results LSR was greater in AMLmf than nccRCC ( P < 0.001). AMLmf showed higher attenuation (all phases), CMP enhancement, and wash-out than nccRCC ( P ≤ 0.001). UTKAD was greater in AMLmf than nccRCC ( P < 0.001). ROC curve analysis yielded area under the curves of 0.936, 0.888, and 0.853 using UTKAD, unenhanced attenuation, and LSR. CART-based algorithm (UTKAD >7.5 HU, LSR > 1.23) predicted AMLmf with sensitivity, specificity, PPV, and NPV of 87.5%, 96.4%, 91.3%, and 94.6%. Mean intra- and inter-observer difference was –0.1/0.03 HU and −1.0/0.09 HU for UTKAD/LSR, respectively. These interpretations changed the final diagnosis in 1.3% (1/79) and 5.1% (4/79) patients for radiologists 1 and 2. Conclusion Triphasic MDCT was useful for differentiating AMLmf and nccRCC. CART-based algorithm using UTKAD > 7.5 and LSR > 1.23 was simple and accurate in predicting AMLmf.
Baseline Neurocognitive Testing in Sports-Related Concussions
Authors: McClure D. Jake , Zuckerman Scott L. , Kutscher Scott J. , Gregory Andrew J. , Solomon Gary S. 
Published: November 2013

Background: The management of sports-related concussions (SRCs) utilizes serial neurocognitive assessments and self-reported symptom inventories to assess recovery and safety for return to play (RTP). Because postconcussive RTP goals include symptom resolution and a return to neurocognitive baseline levels, clinical decisions rest in part on understanding modifiers of this baseline. Several studies have reported age and sex to influence baseline neurocognitive performance, but few have assessed the potential effect of sleep. We chose to investigate the effect of reported sleep duration on baseline Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) performance and the number of patient-reported symptoms. Hypothesis: We hypothesized that athletes receiving less sleep before baseline testing would perform worse on neurocognitive metrics and report more symptoms. Study Design: Cross-sectional study; Level of evidence, 3. Methods: We retrospectively reviewed 3686 nonconcussed athletes (2371 male, 1315 female; 3305 high school, 381 college) with baseline symptom and ImPACT neurocognitive scores. Patients were stratified into 3 groups based on self-reported sleep duration the night before testing: (1) short, <7 hours; (2) intermediate, 7-9 hours; and (3) long, ≥9 hours. A multivariate analysis of covariance (MANCOVA) with an α level of .05 was used to assess the influence of sleep duration on baseline ImPACT performance. A univariate ANCOVA was performed to investigate the influence of sleep on total self-reported symptoms. Results: When controlling for age and sex as covariates, the MANCOVA revealed significant group differences on ImPACT reaction time, verbal memory, and visual memory scores but not visual-motor (processing) speed scores. An ANCOVA also revealed significant group differences in total reported symptoms. For baseline symptoms and ImPACT scores, subsequent pairwise comparisons revealed these associations to be most significant when comparing the short and intermediate sleep groups. Conclusion: Our results indicate that athletes sleeping fewer than 7 hours before baseline testing perform worse on 3 of 4 ImPACT scores and report more symptoms. Because SRC management and RTP decisions hinge on the comparison with a reliable baseline evaluation, clinicians should consider sleep duration before baseline neurocognitive testing as a potential factor in the assessment of athletes’ recovery.
Spiritual Experiences of Transcendence in Patients With Advanced Cancer
Authors: Renz M. , Mao M. Schuett , Omlin A. , Bueche D. , Cerny T. , Strasser F. 
Published: November 2013

Purpose: Spirituality encompasses a wide range of meanings between holistic wellbeing and mysticism. We explored advanced cancer patients' spiritual experiences of transcendence. Methods: A total of 251 patients with advanced cancer were included and observed (participant observation) over 12 months by a psycho-oncologist/music-therapist. She recorded and documented patients' spontaneously expressed spiritual experiences during hospitalisation. Interpretative Phenomenological Analysis was applied. Results: 135 patients communicated a spiritual experience, as expressed by altered body-awareness, less pain, less anxiety, higher acceptance of illness/death, new spiritual identity. Spiritual experiences were communicated by patients across different religious affiliations/attitudes. We identified types of spiritual experiences. Conclusion: The occurrence of spiritual experiences seems to be frequent and associated with profound, powerful reactions. Our results indicate that experienced-based spiritual care may complement current needs-based approaches.
Total Hip and Knee Replacement in the Mature Athlete
Authors: Bloomfield Michael R. , Hozack William J. 
Published: November 2013

Context: Total hip replacement and total knee replacement are among the most successful and common surgical procedures in orthopaedics. These operations were traditionally reserved for older, sedentary patients. However, these are now being increasingly performed in patients expecting to return to athletic activities. Evidence Acquisition: The peer-reviewed medical literature was searched via PubMed from the years 2000 to 2013. Those studies pertinent to modern hip and knee replacement in an athletic population were selected for inclusion. Study Design: Literature review. Level of Evidence: Level 4. Results: There is a lack of high-quality evidence in the peer-reviewed literature relating to the replacement of hips and knees in younger athletic patients. Although many patients undergoing joint replacement are active in recreational activities, a minority engage in high-impact sports. Following surgery, overall activities tend to increase, but high-demand athletic activities may be limited by pain, functional outcome, or activity restrictions imposed by health care providers. Conclusion: Patients receiving hip and knee replacements should be counseled in that returning to high-impact and repetitive-loading athletic activities after surgery may shorten the life span of their implant. Strength-of-Recommendation Taxonomy (SORT): C.
SMARTS (Systematic Monitoring of Adverse events Related to TreatmentS): The development of a pragmatic patient-completed checklist to assess antipsychotic drug side effects
Authors: Haddad Peter M , Fleischhacker W Wolfgang , Peuskens Joseph , Cavallaro Roberto , Lean Michael EJ , Morozova Margarita , Reynolds Gavin , Azorin Jean-Michel , Thomas Pierre , Möller Hans-Jürgen 
Published: November 2013

Objectives: Antipsychotic drug side effects are common and can cause stigmatisation, decreased quality of life, poor adherence, and secondary morbidity and mortality. Systematic assessment of anticipated side effects is recommended as part of good clinical care, but is uncommon in practice and patients may not spontaneously report side effects. We aimed to develop a simple patient-completed checklist to screen systematically for potential antipsychotic side effects. Methods: The SMARTS checklist was developed over a series of group meetings by an international faculty of 12 experts (including psychiatrists, a general physician and a psychopharmacologist) based on their clinical experience and knowledge of the literature. The emphasis is on tolerability (i.e. assessment of side effects that ‘trouble’ the patient) as subjective impact of side effects is most relevant to medication adherence. The development took account of feedback from practising psychiatrists in Europe, the Middle East and Africa, a process that contributed to face validity. Results: The SMARTS checklist assesses whether patients are currently ‘troubled’ by 11 well-established potential antipsychotic side effects. Patients provide their responses to these questions by circling relevant side effects. An additional open question enquires about any other possible side effects. The checklist has been translated into Italian and Turkish. Conclusions: The SMARTS checklist aims to strike a balance between brevity and capturing the most common and important antipsychotic side effects. It is appropriate for completion by patients prior to a clinical consultation, for example, in the waiting room. It can then form the focus for a more detailed clinical discussion about side effects. It can be used alone or form part of a more comprehensive assessment of antipsychotic side effects including blood tests and a physical examination when appropriate. The checklist assesses current problems and can be used longitudinally to assess change.
MetSizeR: selecting the optimal sample size for metabolomic studies using an analysis based approach
Authors: Nyamundanda Gift , Gormley Isobel Claire , Fan Yue , Gallagher William M , Brennan Lorraine 
Published: November 2013

AbstractBackgroundDetermining sample sizes for metabolomic experiments is important but due to the complexity of these experiments, there are currently no standard methods for sample size estimation in metabolomics. Since pilot studies are rarely done in metabolomics, currently existing sample size estimation approaches which rely on pilot data can not be applied.ResultsIn this article, an analysis based approach called MetSizeR is developed to estimate sample size for metabolomic experiments even when experimental pilot data are not available. The key motivation for MetSizeR is that it considers the type of analysis the researcher intends to use for data analysis when estimating sample size. MetSizeR uses information about the data analysis technique and prior expert knowledge of the metabolomic experiment to simulate pilot data from a statistical model. Permutation based techniques are then applied to the simulated pilot data to estimate the required sample size.ConclusionsThe MetSizeR methodology, and a publicly available software package which implements the approach, are illustrated through real metabolomic applications. Sample size estimates, informed by the intended statistical analysis technique, and the associated uncertainty are provided.