bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review of college-level health textbooks for coverage of type 2 diabetes, prediabetes, and metabolic syndrome
Authors: Ethan Danna , Rennis Lesley , Samuel Lalitha , Seidel Erica J , Basch Corey H 
Published: February 2013

Objective: Type 2 diabetes, prediabetes, and metabolic syndrome are increasingly relevant health problems for United States (US) college-aged students and their family members. This study’s aim was to determine the extent to which these chronic conditions were covered in leading college-level personal health textbooks and to what degree the books emphasized the preventive steps students can take to promote their health and minimize development or worsening of these conditions. Design: A convenience sample of 10 leading college-level personal health textbooks was used in this cross-sectional study. Setting: Textbooks selected for analysis are frequently used in introductory personal health courses on college campuses across the US. Method: Textbooks were coded for level of coverage for select criteria that included risk factors, definitions, prevalence among college-aged youth, African Americans, and Hispanics, serious consequences associated with unmanaged type 2 diabetes, presence of self-assessment tool, prediabetes’ and metabolic syndrome’s association with type 2 diabetes, prevention strategies, student portrayals, and messages geared towards students living with these conditions. Results: Exemplary coverage of information related to diabetes, prediabetes, and metabolic syndrome was uncommon for the following criteria: prevalence among African Americans and Hispanics, depiction of a student with diabetes or prediabetes, prevalence of messages geared toward readers with these conditions, and in-depth discussion of prevention strategies. Conclusion: More thorough coverage in personal health textbooks is necessary given the rising prevalence of these health problems in young adults, the positive impact of healthy lifestyle choices, and the formal opportunity for learning presented through college personal health courses.
Effectiveness of a Selective Partial Adductor Release for Chronic Adductor-Related Groin Pain in Professional Athletes
Authors: Schilders Ernest , Dimitrakopoulou Alexandra , Cooke Michael , Bismil Quamar , Cooke Carlton 
Published: February 2013

Background: Chronic adductor enthesopathy is a well-known cause of groin pain in athletes. Currently, percutaneous nonselective adductor tenotomies give mixed results and not always predictable outcomes. Hypothesis: A selective partial adductor longus release as treatment for recalcitrant chronic adductor longus enthesopathy provides excellent pain relief with a prompt and consistent return to preinjury levels of sport. Study Design: Case series; Level of evidence, 4. Methods: All athletes were assessed in a standard way for adductor dysfunction. They received radiographs and a specifically designed magnetic resonance imaging groin study protocol. Only professional athletes who received a selective partial adductor release were included. Pain and functional improvement were assessed with the visual analog scale (VAS) pain score and time to return to sport. Results: Forty-three professional athletes (39 soccer and 4 rugby) with chronic adductor-related groin pain were treated with a selective partial adductor release. The average follow-up time was 40.2 months (range, 25-72 months). Forty-two of 43 athletes returned to their preinjury level of sport after an average of  9.21 weeks (range, 4-24 weeks; SD, 4.68 weeks). The preoperative VAS score improved significantly (Wilcoxon signed-rank test, P < .001) from 5.76 ± 1.08 (range, 3-8) to 0.23 ± 0.61 (range, 0-3) postoperatively. Conclusion: A selective partial adductor longus release provides excellent pain relief for chronic adductor enthesopathy in professional athletes with a consistent high rate of return to the preinjury level of sport.
Lifetime exposure to low doses of lead in rats
Authors: Nováková Jaroslava , Lukačínová Agnesa , Lovásová Eva , Cimboláková Iveta , Rácz Oliver , Ništiar František 
Published: February 2013

The aim of the study was to assess the effects of exposure to low doses of lead dissolved in drinking water (average daily dose of 2.2 mg kg−1 day−1) on selected carbohydrate metabolism parameters in 20 wistar rats. Animals were divided into two groups – control (C) (group drinking clear water) and experimental group (Pb; group exposed to low doses of lead acetate in a concentration of 100 μmol l−1 of drinking water). In this study, we studied the biochemical parameters (glucose, haemoglobin (Hb), glycated haemoglobin (HbA1c), lactate dehydrogenase (LDH) and amylase (AMS)) in rat blood. Glucose and Hb concentration and AMS activity decreased, LDH activity increased but HbA1c concentration levels did not change in rats exposed to lead. Our results well documented that lifetime exposure to lead affected carbohydrate metabolism of rats. Some parameters like concentration of Hb as well as activities of AMS and LDH are useful markers of intoxication of rats with lead. For the evaluation of results (e.g. AMS), not only the data at the end of the experiment should be taken into account but also the entire duration of trials (i.e. more time steps) that makes results more objective should be considered.
Vascular Disruption of the Talus
Authors: Phisitkul Phinit , Haugsdal Jaclyn , Vaseenon Tanawat , Pizzimenti Marc A. 
Published: February 2013

Background: For triple arthrodesis, a single medial incision has been proposed to avoid lateral wound complications and has demonstrated satisfactory fusion rates. This study aimed to compare the disruption to the arterial supply of the talus between the single-medial-incision approach and the 2-incision approach. Methods: The 2 approaches for triple arthrodesis were compared by analyzing the disruption of arterial vasculature in 14 cadaveric specimens in randomized fashion. The arterial disruption was determined using CT angiography before and after surgery combined with analysis from dissection. The area of joint preparation from each technique was also analyzed and compared. Results: The single-medial-incision approach caused a high incidence of damage to the deltoid artery (6 of 7 specimens, 86%) and the artery of the tarsal canal (7 of 7 specimens, 100%). The 2-incision approach resulted in damage to the artery of the tarsal sinus in all specimens (7 of 7 specimens, 100%), but the medial vasculature was spared given the limited dissection required to access the talonavicular joint. Through the single-medial-incision approach the percentage of debridement of the calcaneocuboid joint (36%) was significantly lower than the debridement using the 2-incision approach (85%, P < .01). There was no significant difference in joint preparation of the talonavicular and subtalar joints between the 2 approaches with the number of specimens available. Conclusion: From this cadaveric study, we found that both approaches could result in substantial disruption of the main blood supply to the talus. The single-medial-incision approach consistently disrupted the majority of blood supply to the talar body, while the 2-incision approach caused various degrees of vascular disruption to the talar head and neck. Using the single-medial-incision approach, the calcaneocuboid joint did not show adequate removal of articular cartilage due to difficulty accessing the joint surfaces. Clinical Relevance: Vascular sparing to the talus should be considered when selecting an appropriate operative approach for triple arthrodesis. Although the clinical significance of this cadaveric study is limited, the 2-incision approach appeared to cause less vascular disruption to the talar body while allowing more complete joint preparation.
IL-21–stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation
Authors: Karrich Julien J. , Jachimowski Loes C. M. , Nagasawa Maho , Kamp Angela , Balzarolo Melania , Wolkers Monika C. , Uittenbogaart Christel H. , Marieke van Ham S. , Blom Bianca 
Published: February 2013

Key Points
pDCs functionally express the IL-21 receptor and produce granzyme B in response to IL-21. IL-21–induced granzyme B in pDC impairs pDC's capacity to induce T-cell proliferation.
Phase 2 study of arsenic trioxide followed by autologous hematopoietic cell transplantation for relapsed acute promyelocytic leukemia
Authors: Yanada Masamitsu , Tsuzuki Motohiro , Fujita Hiroyuki , Fujimaki Katsumichi , Fujisawa Shin , Sunami Kazutaka , Taniwaki Masafumi , Ohwada Akira , Tsuboi Kosuke , Maeda Akio , Takeshita Akihiro , Ohtake Shigeki , Miyazaki Yasushi , Atsuta Yoshiko , Kobayashi Yukio , Naoe Tomoki , Emi Nobuhiko 
Published: February 2013

Key Points
We conducted a phase 2 study of ATO followed by autologous HCT for relapsed APL. This sequential treatment is effective and feasible.
The E3 ubiquitin ligase UBR5 is recurrently mutated in mantle cell lymphoma
Authors: Meissner Barbara , Kridel Robert , Lim Raymond S. , Rogic Sanja , Tse Kane , Scott David W. , Moore Richard , Mungall Andy J. , Marra Marco A. , Connors Joseph M. , Steidl Christian , Gascoyne Randy D. 
Published: February 2013

Key Points
UBR5 is recurrently mutated in mantle cell lymphoma with a C-terminal cluster of deleterious mutations.
Factors influencing diagnosis and treatment of osteoporosis after a fragility fracture among postmenopausal women in Asian countries: a retrospective study
Authors: Kung Annie W , Fan Tao , Xu Ling , Xia Wei B , Park Il Hyung , Kim Hak Sun , Chan Siew Pheng , Lee Joon Kiong , Koh Leonard , Soong Yung Kuei , Soontrapa Suppasin , Songpatanasilp Thawee , Turajane Thana , Yates Marc , Sen Shuvayu 
Published: February 2013

Abstract

Background
A vast amount of literature describes the incidence of fracture as a risk for recurrent osteoporotic fractures in western and Asian countries. Osteoporosis evaluation and treatment after a low-trauma fracture, however, has not been well characterized in postmenopausal women in Asia. The purpose of this study was to characterize patient and health system characteristics associated with the diagnosis and management of osteoporosis among postmenopausal women hospitalized with a fragility fracture in Asia.

Methods
Patient surveys and medical charts of postmenopausal women (N=1,122) discharged after a fragility hip fracture from treatment centers in mainland China, Hong Kong, Singapore, South Korea, Malaysia, Taiwan, and Thailand between July 1, 2006 and June 30, 2007 were reviewed for bone mineral density (BMD) measurement, osteoporosis diagnosis, and osteoporosis treatment.

Results
The mean (SD) age was 72.9 (11.5) years. A BMD measurement was reported by 28.2% of patients, 51.5% were informed that they had osteoporosis, and 33.0% received prescription medications for osteoporosis in the 6 months after discharge. Using multivariate logistic regression analyses, prior history of fracture decreased the odds of a BMD measurement (OR 0.63, 95% CI 0.45-0.88). Having a BMD measurement increased the odds of osteoporosis diagnosis (OR 10.1, 95% CI 6.36-16.0), as did having health insurance (OR 4.95, 95% CI 1.51-16.21 for private insurance with partial self-payment relative to 100% self-payment). A history of fracture was not independently associated with an osteoporosis diagnosis (OR 0.80, 95% CI 0.56-1.15). Younger age reduced the odds of receiving medication for osteoporosis (OR 0.59, 95% CI 0.36-0.96 relative to age ≥65), while having a BMD measurement increased the odds (OR 1.79, 95% CI 1.23-2.61).

Conclusions
Osteoporosis diagnosis and treatment in Asian countries were driven by BMD measurement but not by fracture history. Future efforts should emphasize education of general practitioners and patients about the importance of fracture.
Mitochondrial genome sequences reveal deep divergences among Anopheles punctulatus sibling species in Papua New Guinea
Authors: Logue Kyle , Chan Ernest R , Phipps Tenisha , Small Scott T , Reimer Lisa , Henry-Halldin Cara , Sattabongkot Jetsumon , Siba Peter M , Zimmerman Peter A , Serre David 
Published: February 2013

AbstractBackgroundMembers of theAnopheles punctulatusgroup (AP group) are the primary vectors of human malaria in Papua New Guinea. The AP group includes 13 sibling species, most of them morphologically indistinguishable. Understanding why only certain species are able to transmit malaria requires a better comprehension of their evolutionary history. In particular, understanding relationships and divergence times amongAnophelesspecies may enable assessing how malaria-related traits (e.g. blood feeding behaviours, vector competence) have evolved.MethodsDNA sequences of 14 mitochondrial (mt) genomes from five AP sibling species and two species of theAnopheles diruscomplex of Southeast Asia were sequenced. DNA sequences from all concatenated protein coding genes (10,770 bp) were then analysed using a Bayesian approach to reconstruct phylogenetic relationships and date the divergence of the AP sibling species.ResultsPhylogenetic reconstruction using the concatenated DNA sequence of all mitochondrial protein coding genes indicates that the ancestors of the AP group arrived in Papua New Guinea 25 to 54 million years ago and rapidly diverged to form the current sibling species.ConclusionThrough evaluation of newly described mt genome sequences, this study has revealed a divergence among members of the AP group in Papua New Guinea that would significantly predate the arrival of humans in this region, 50 thousand years ago. The divergence observed among the mtDNA sequences studied here may have resulted from reproductive isolation during historical changes in sea-level through glacial minima and maxima. This leads to a hypothesis that the AP sibling species have evolved independently for potentially thousands of generations. This suggests that the evolution of many phenotypes, such as insecticide resistance will arise independently in each of the AP sibling species studied here.
Numerical approximation to a solution of the modified regularized long wave equation using quintic B-splines
Authors: Karakoc Seydi Battal Gazi , Yagmurlu Nuri Murat , Ucar Yusuf 
Published: February 2013

Abstract
In this work, a numerical solution of the modified regularized long wave (MRLW) equation is obtained by the method based on collocation of quintic B-splines over the finite elements. A linear stability analysis shows that the numerical scheme based on Von Neumann approximation theory is unconditionally stable. Test problems including the solitary wave motion, the interaction of two and three solitary waves and the Maxwellian initial condition are solved to validate the proposed method by calculating error norms

L
2

and

L
∞

that are found to be marginally accurate and efficient. The three invariants of the motion have been calculated to determine the conservation properties of the scheme. The obtained results are compared with other earlier results.

MSC: 97N40, 65N30, 65D07, 76B25, 74S05.
Sodium vanadate combined with l-ascorbic acid delays disease progression, enhances motor performance, and ameliorates muscle atrophy and weakness in mice with spinal muscular atrophy
Authors: Liu Huei-Chun , Ting Chen-Hung , Wen Hsin-Lan , Tsai Li-Kai , Hsieh-Li Hsiu-Mei , Li Hung , Lin-Chao Sue 
Published: February 2013

Abstract

Background
Proximal spinal muscular atrophy (SMA), a neurodegenerative disorder that causes infant mortality, has no effective treatment. Sodium vanadate has shown potential for the treatment of SMA; however, vanadate-induced toxicity in vivo remains an obstacle for its clinical application. We evaluated the therapeutic potential of sodium vanadate combined with a vanadium detoxification agent, L-ascorbic acid, in a SMA mouse model.

Methods
Sodium vanadate (200 μM), L-ascorbic acid (400 μM), or sodium vanadate combined with L-ascorbic acid (combined treatment) were applied to motor neuron-like NSC34 cells and fibroblasts derived from a healthy donor and a type II SMA patient to evaluate the cellular viability and the efficacy of each treatment in vitro. For the in vivo studies, sodium vanadate (20 mg/kg once daily) and L-ascorbic acid (40 mg/kg once daily) alone or in combination were orally administered daily on postnatal days 1 to 30. Motor performance, pathological studies, and the effects of each treatment (vehicle, L-ascorbic acid, sodium vanadate, and combined treatment) were assessed and compared on postnatal days (PNDs) 30 and 90. The Kaplan-Meier method was used to evaluate the survival rate, with P < 0.05 indicating significance. For other studies, one-way analysis of variance (ANOVA) and Student's t test for paired variables were used to measure significant differences (P < 0.05) between values.

Results
Combined treatment protected cells against vanadate-induced cell death with decreasing B cell lymphoma 2-associated X protein (Bax) levels. A month of combined treatment in mice with late-onset SMA beginning on postnatal day 1 delayed disease progression, improved motor performance in adulthood, enhanced survival motor neuron (SMN) levels and motor neuron numbers, reduced muscle atrophy, and decreased Bax levels in the spinal cord. Most importantly, combined treatment preserved hepatic and renal function and substantially decreased vanadium accumulation in these organs.

Conclusions
Combined treatment beginning at birth and continuing for 1 month conferred protection against neuromuscular damage in mice with milder types of SMA. Further, these mice exhibited enhanced motor performance in adulthood. Therefore, combined treatment could present a feasible treatment option for patients with late-onset SMA.
New clinical and molecular insights on Barth syndrome
Authors: Ferri Lorenzo , Donati Maria Alice , Funghini Silvia , Malvagia Sabrina , Catarzi Serena , Lugli Licia , Ragni Luca , Bertini Enrico , Vaz Frédéréc M , Cooper David N , Guerrini Renzo , Morrone Amelia 
Published: February 2013

Abstract

Background
Barth syndrome (BS) is an X-linked infantile-onset cardioskeletal disease characterized by cardiomyopathy, hypotonia, growth delay, neutropenia and 3-methylglutaconic aciduria. It is caused by mutations in the TAZ gene encoding tafazzin, a protein involved in the metabolism of cardiolipin, a mitochondrial-specific phospholipid involved in mitochondrial energy production.

Methods
Clinical, biochemical and molecular characterization of a group of six male patients suspected of having BS. Three patients presented early with severe metabolic decompensation including respiratory distress, oxygen desaturation and cardiomyopathy and died within the first year of life. The remaining three patients had cardiomyopathy, hypotonia and growth delay and are still alive. Cardiomyopathy was detected during pregnancy through a routine check-up in one patient. All patients exhibited 3-methylglutaconic aciduria and neutropenia, when tested and five of them also had lactic acidosis.

Results
We confirmed the diagnosis of BS with sequence analysis of the TAZ gene, and found five new mutations, c.641A>G p.His214Arg, c.284dupG (p.Thr96Aspfs*37), c.678_691del14 (p.Tyr227Trpfs*79), g.8009_16445del8437 and g.[9777_9814del38; 9911-?_14402del] and the known nonsense mutation c.367C>T (p.Arg123Term). The two gross rearrangements ablated TAZ exons 6 to 11 and probably originated by non-allelic homologous recombination and by Serial Replication Slippage (SRS), respectively. The identification of the breakpoints boundaries of the gross deletions allowed the direct detection of heterozygosity in carrier females.

Conclusions
Lactic acidosis associated with 3-methylglutaconic aciduria is highly suggestive of BS, whilst the severity of the metabolic decompensation at disease onset should be considered for prognostic purposes. Mutation analysis of the TAZ gene is necessary for confirming the clinical and biochemical diagnosis in probands in order to identify heterozygous carriers and supporting prenatal diagnosis and genetic counseling.
Assessment of inhibitory potential of essential oils on natural mycoflora and Fusarium mycotoxins production in wheat
Authors: Sumalan Renata-Maria , Alexa Ersilia , Poiana Mariana-Atena 
Published: February 2013

Abstract

Background
In the last years essential oils from different plants were used in the prevention of fungi and mycotoxins accumulation in cereals. The most attractive aspect derived from using of essential oils as seed grains protectants is due to their non-toxicity. This study was focused on assessment the inhibitory effect of some essential oils: Melissa officinalis (O1), Salvia officinalis (O2), Coriandrum sativum (O3), Thymus vulgaris (O4) Mentha piperita (O5) and Cinnamomum zeylanicum (O6) against natural mycoflora and Fusarium mycotoxins production correlated with their antioxidants properties.

Results
All essential oils showed inhibitory effect on fungal contamination of wheat seeds. This ability was dose-dependent. The highest inhibitory effect on Fusarium and Aspergillus fungi was recorded after 5 days of treatment. Fungi such as yeast (Pichia, Saccharomyces and Hyphopichia) were predominantly on seeds mycoflora after 22 days. Each treatment had a selective inhibitory effect on frequency of fungus genera. After 5 days of treatment the most fungicidal effect was recorder for O4, followed by O1. In terms of essential oils effect on mycotoxins development, the best control on fumonisins (FUMO) production was recorded for O6. The antioxidant properties of essential oils decreased in order: O4 > O1 > O6 > O5 > O2 > O3. Also, our data suggested that there is a significant negative correlation between antioxidant properties and seed contamination index (SCI), but there was not recorded a good correlation between antioxidant properties and FUMO content.

Conclusions
Based on proven antifungal and antimycotoxin effects as well as their antioxidant properties, the essential oils could be recommended as natural preservatives for stored cereals. The highest inhibition of fungal growth was noted after 5 days of treatment and decreased after 22 days.