bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subsiciva Byzantina
Authors: Schminck Andreas 
Published: June 2015

I	Zur ‘constitutio’ Βασιλικῆς – The Greek translation ‘Βασιλικῆς’ of the Latin constitutio Imperatoriam introducing Justinian’s Institutiones was not written in the 6th century but in the eighties of the 9th century. The translator could have been the grammarian Theognostos. II	Συμβόλαιον – The importance of the term συμβόλαιον in the proem and title 13 of the Eisagoge of 886 is not due to a scholion of the 6th century but to patriarch Photios’ definition of the word in compiling the Eisagoge. III	Καινοτομία – The term ‘kainotomia’ (originally ‘opening of new mines’ and then, metaphorically, ‘innovation’) had no particular juristic meaning in the 6th century, whereas from the end of the 9th century almost all Byzantine law books contained a specific title about ‘kainotomiai’. The author suggests that the patriarch Photios, when composing the proem of the Eisagoge and mentioning there the ‘sinful kainotomiai’, thought of the theological meaning of the term, namely ‘heresy’. His collaborator however, probably Stylianos Zaoutzes, did not fulfil Photios’ ideas in compiling a list of heresies, but created a new extremely vague juristic term stemming from the ‘opus novum’ in the Corpus iuris civilis. This sheds light on the codification process in the last year of the emperor Basil I († August 28th, 886): When Photios wrote the preface to the Eisagoge in 885 or 886, its text was not yet finished; otherwise such a ‘misunderstanding’ would be unexplainable.
Three new species of Eugenia (Myrtaceae) from Brazilian Amazonia
Authors: Souza Maria-Anália Duarte , Scudeller Veridiana Vizoni , De Mendonça Maria-Sílvia 
Published: June 2015

Three new species of Eugenia occurring in Brazilian Amazonian rainforest are described and illustrated: Eugenia kerianthera, Eugenia caducipetala and Eugenia marleneae. Eugenia kerianthera is related to Eugenia yasuniana, from which it is distinguished by its deltoid bracts and setaceous bracteoles, persistent and widely deltoid sepals, and oblong to obovate petals. Eugenia caducipetala is similar to Eugenia exaltata but is differentiated by leaves with flat margins and midvein convex adaxially. Eugenia marleneae is similar to Eugenia gomesiana and Eugenia trinervia, being distinguished from the first by its orbicular bracteoles and from the second by its fasciculate inflorescences. Phenological data, geographical distributions and further comparisons with morphologically similar species are provided.
Comparison of NLDAS-2 Simulated and NASMD Observed Daily Soil Moisture. Part II: Impact of Soil Texture Classification and Vegetation Type Mismatches
Authors: Xia Youlong , Ek Michael B. , Wu Yihua , Ford Trent , Quiring Steven M. 
Published: June 2015

AbstractIn this second part of a two-part paper, the impacts of soil texture and vegetation type misclassification and their combined effect on soil moisture, evapotranspiration, and total runoff simulation are investigated using the Noah model. The results show that these impacts are significant for most regions and soil layers, although they vary depending on soil texture classification, vegetation type, and season. The use of site-observed soil texture classification and vegetation type in the model does not necessarily improve anomaly correlations and reduce mean absolute error for soil moisture simulations. Instead, results are mixed when examining all regions and soil layers. This is attributed to the compensation effects (e.g., effect of ill-calibrated model parameters), as Noah has been more or less calibrated with model-specified soil texture classification and vegetation type. The site-based analysis shows that Noah can reasonably simulate the variation of daily evapotranspiration, soil moisture, and total runoff when soil texture classification (vegetation type) is corrected from loam (forest) to clay (grasslands) or vice versa. This suggests that the performance of Noah can be further improved by tuning model parameters when site-observed soil texture and vegetation type are used.
Indicators of Climate Change in Idaho: An Assessment Framework for Coupling Biophysical Change and Social Perceptiona
Authors: Klos P. Zion , Abatzoglou John T. , Bean Alycia , Blades Jarod , Clark Melissa A. , Dodd Megan , Hall Troy E. , Haruch Amanda , Higuera Philip E. , Holbrook Joseph D. , Jansen Vincent S. , Kemp Kerry , Lankford Amber , Link Timothy E. , Magney Troy , Meddens Arjan J. H. , Mitchell Liza , Moore Brandon , Morgan Penelope , Newingham Beth A. , Niemeyer Ryan J. , Soderquist Ben , Suazo Alexis A. , Vierling Kerri T. , Walden Von , Walsh Chelsea 
Published: June 2015

Abstract
Climate change is well documented at the global scale, but local and regional changes are not as well understood. Finer, local- to regional-scale information is needed for creating specific, place-based planning and adaption efforts. Here the development of an indicator-focused climate change assessment in Idaho is described. This interdisciplinary framework couples end users’ data needs with observed, biophysical changes at local to regional scales. An online statewide survey of natural resource professionals was conducted to assess the perceived impacts from climate change and determine the biophysical data needed to measure those impacts. Changes to water resources and wildfire risk were the highest areas of concern among resource professionals. Guided by the survey results, 15 biophysical indicator datasets were summarized that included direct climate metrics (e.g., air temperature) and indicators only partially influenced by climate (e.g., wildfire). Quantitative changes in indicators were determined using time series analysis from 1975 to 2010. Indicators displayed trends of varying likelihood over the analysis period, including increasing growing-season length, increasing annual temperature, increasing forest area burned, changing mountain bluebird and lilac phenology, increasing precipitation intensity, earlier center of timing of streamflow, and decreased 1 April snowpack; changes in volumetric streamflow, salmon migration dates, and stream temperature displayed the least likelihood. A final conceptual framework derived from the social and biophysical data provides an interdisciplinary case example useful for consideration by others when choosing indicators at local to regional scales for climate change assessments.
Professional values and organizational change dynamics: the case of the reform of doctoral training in France
Authors: Dahan Aubépine 
Published: June 2015

At a time when the reforms inspired by New Public Management are prompting a hybridization of values, there is growing reference to the notion of values in managerial discourses within public organizations. While some studies consider the statement of values as a direct lever of change, others show that they are more of an obstacle. The studies that make use of institutional logics or economies of worth suggest a dynamic of change involving values, without exploring it as such. Focusing on the context of public professional organizations, this article explores the link between values and change by focusing on the process of adoption of new practices in response to a reform. Our qualitative research among academics during the implementation of the reform of doctoral training in France confirms that professional autonomy is often against reform, but also reveals that ‘professional values’ do not form a coherent and fixed whole: they are plural and generate a series of tensions that are, in turn, reflected by practices. The reform has the effect of inflaming controversies, leading to a possible change brought about by the professionals themselves. Points for practitioners This article challenges the view of professional values as a mechanical source of immobilization, and the interest of a purely discursive use of the values to support change. Professional values appear more as an endogenous source of change than as leverage available to management in times of a reform.
Practice Arrangement and Medicare Physician Payment in Otolaryngology
Authors: Cracchiolo Jennifer , Ridge John A. , Egleston Brian , Lango Miriam 
Published: June 2015

ObjectiveMedicare Part B physician payment indicates a cost to Medicare beneficiaries for a physician service and connotes physician clinical productivity. The objective of this study was to determine whether there was an association between practice arrangement and Medicare physician payment.Study DesignCross‐sectional study.SettingMedicare provider utilization and payment data.Subjects and MethodsOtolaryngologists from 1 metropolitan area were included as part of a pilot study. A generalized linear model was used to determine the effect of practice‐specific variables including patient volumes on physician payment.ResultsOf 67 otolaryngologists included, 23 (34%) provided services through an independent practice, while others were employed by 1 of 3 local academic centers. Median payment was $58,895 per physician for the year, although some physicians received substantially higher payments. Reimbursements to faculty at 1 academic department were higher than to those at other institutions or to independent practitioners. After adjustments were made for patient volumes, physician subspecialty, and gender, payments to each faculty at Hospital C were 2 times higher than to those at Hospital A (relative ratio [RR] 2.03; 95% CI, 1.27‐3.27; P =. 003); 2 times higher than to faculty at Hospital B (RR 2.04; 95% CI, 1.4‐2.7; P =. 0001); and 1.6 times higher than to independent practitioners (RR 1.6; 95% CI, 1.04‐2.7; P =. 03). Payments to physicians in the other groups were not significantly different. Differences in reimbursement corresponded to an emphasis on procedures over office visits but not Medicare case mix adjustments for patient discharges from associated institutions.ConclusionsVariation in the cost of academic otolaryngology care may be subject in part to institutional factors.
The influence of age and gender on venous symptomatology. An epidemiological survey in Belgium and Luxembourg
Authors: Vuylsteke Marc E , Colman Roos , Thomis Sarah , Guillaume Geneviève , Degrande Evy , Staelens Ivan 
Published: June 2015

Aim The aim of this study is to measure the incidence of the symptoms in patients with chronic venous disease (CVD) and to look for the influence of age on the severity of symptoms for both genders. Materials and methods A survey was carried out in Belgium and Luxembourg between May and September 2013. Patient recruitment was done by 406 general practitioners (GPs). Each GP screened 10–20 consecutive patients older than 18 years. Inquiries were made regarding the presence of symptoms and possible signs of CVD. Patients with diagnosed CVD filled out a questionnaire including a quality of life score (CIVIQ-14). These data were converted into a CIVIQ Global Index Score (GIS). Statistical analysis was performed in order to calculate the effect of age and gender on the number of symptoms and the estimated probabilities of having CVD. Results Totally 6009 patients were included in this survey. The mean age was 53.4 years. Of all, 61.3% of the patients have CVD (C1-C6). Of all, 64.7% of patients were symptomatic. Age and female gender were major risk factors for developing CVD. Most common symptoms were ‘heavy legs’ (70.4%), pain (54.0%), and sensation of swelling (52.7%). The number of symptoms increases with age ( p < 0.001). Female patients have significantly more symptoms in comparison with male patients in all age groups. In both females and males, age is negatively correlated with GIS score ( p < 0.001). The estimated probability of having CVD was significantly higher for woman compared to men and increases with age for both gender. Conclusion CVD is a very common progressive disease with age as a major risk factor. Increasing age results in a higher C-classification, more symptoms, and a lower GIS score (quality of life). Female gender interacts significantly with age and results in a more advanced stage of CVD.
The Impact of Addressing Adherence in Pharmacist-Managed Pharmacotherapy Clinics
Authors: Sharaya Nora H. , Dorrell Megan F. , Sciacca Nick A. 
Published: June 2015

Purpose: The primary objective of this study was to determine the change in the adherence questionnaire score from the initial pharmacist intervention to 60 to 90 days follow-up. The secondary objective of this study was to investigate the impact of the type of pharmacist intervention on questionnaire scores. Methods: Administration of an adherence questionnaire to guide interventions has become the standard of care for patients during appointments with clinical pharmacy specialists at 3 primary care clinics. Subjects who received a questionnaire between November 4, 2013, and January 15, 2014, were included. These subjects received a second questionnaire 60 to 90 days after the first questionnaire to identify changes resulting from the pharmacist’s interventions. A scoring system was utilized to quantify patients’ responses to both the preintervention and postintervention questionnaires. The type of intervention completed was determined at each pharmacist’s clinical discretion. Results: Adherence scores increased significantly 60 to 90 days after administration of the questionnaire with a pharmacist’s intervention. Medication reminders, simplifying medication regimens, discount program referrals, disease-state information, medication information, and therapeutic interchanges, all increased adherence scores. Conclusion: A standardized tool to assess and address adherence was effectively utilized by 9 pharmacists at 3 clinics. The use of a standardized tool to guide adherence interventions is an effective way to increase adherence to medication therapy.
Physicians’ Preferences for Communication of Pharmacist-Provided Medication Therapy Management in Community Pharmacy
Authors: Guthrie Kendall D. , Stoner Steven C. , Hartwig D. Matthew , May Justin R. , Nicolaus Sara E. , Schramm Andrew M. , DiDonato Kristen L. 
Published: June 2015

Objectives: (1) To identify physicians’ preferences in regard to pharmacist-provided medication therapy management (MTM) communication in the community pharmacy setting; (2) to identify physicians’ perceived barriers to communicating with a pharmacist regarding MTM; and (3) to determine whether Missouri physicians feel MTM is beneficial for their patients. Methods: A cross-sectional prospective survey study of 2021 family and general practice physicians registered with MO HealthNet, Missouri’s Medicaid program. Results: The majority (52.8%) of physicians preferred MTM data to be communicated via fax. Most physicians who provided care to patients in long-term care (LTC) facilities (81.0%) preferred to be contacted at their practice location as opposed to the LTC facility. The greatest barriers to communication were lack of time and inefficient communication practices. Improved/enhanced communication was the most common suggestion for improvement in the MTM process. Approximately 67% of respondents reported MTM as beneficial or somewhat beneficial for their patients. Conclusions: Survey respondents saw value in the MTM services offered by pharmacists. However, pharmacists should use the identified preferences and barriers to improve their currently utilized communication practices in hopes of increasing acceptance of recommendations. Ultimately, this may assist MTM providers in working collaboratively with patients’ physicians.
Marked cytoreduction of a lymphocyte-rich mediastinal thymoma with neoadjuvant chemotherapy in a cat
Authors: Tong Linda J , Hosgood Giselle , Labruyère Julien , Bennett Susan L , FitzGerald Louise , Shiel Robert E 
Published: June 2015

Case summary A 15-year-old neutered female domestic shorthair cat presented with lethargy and acute-onset dyspnoea. Thoracic computed tomography (CT) revealed a large, cranial mediastinal mass with an estimated volume of 180.7 cm3. Chemotherapy consisting of dexamethasone followed by L-asparaginase, prednisolone, vincristine and doxorubicin was commenced owing to the severity of disease and initial possibility of lymphoma. A diagnosis of lymphocyte-rich thymoma was made based upon histological examination, positive pancytokeratin staining, variable lymphocyte CD3 expression and T cell receptor gamma polyclonality. Thoracic CT performed 35 days after the commencement of chemotherapy showed a marked reduction in the size of the mass, with an estimated volume of 9.4 cm3. A median sternotomy and thymectomy were performed. No clinical signs have recurred 34 months after surgery. Conclusions and relevance The response to chemotherapy in this case was unusual, and is likely associated with the high non-neoplastic lymphoid component of the mass. The case demonstrates that preoperative chemotherapy can be used to reduce thymoma volume prior to surgery, potentially decreasing anaesthetic risk.
Antileukemia activity of the novel peptidic CXCR4 antagonist LY2510924 as monotherapy and in combination with chemotherapy
Authors: Cho Byung-Sik , Zeng Zhihong , Mu Hong , Wang Zhiqiang , Konoplev Sergej , McQueen Teresa , Protopopova Marina , Cortes Jorge , Marszalek Joseph R. , Peng Sheng-Bin , Ma Wencai , Davis R. Eric , Thornton Donald E. , Andreeff Michael , Konopleva Marina 
Published: June 2015

Key Points
In vitro, SDF-1α/CXCR4 inhibition by LY2510924 is potent and prolonged and inhibits proliferation and stromal chemoprotection of AML cells. In vivo, LY2510924 mobilizes AML cells, has striking antileukemia effects as monotherapy, and strongly synergizes with chemotherapy.
Risk and Cause of Death in Patients Diagnosed With Myeloproliferative Neoplasms in Sweden Between 1973 and 2005: A Population-Based Study
Authors: Hultcrantz Malin , Wilkes Sally R. , Kristinsson Sigurdur Y. , Andersson Therese M.-L. , Derolf Åsa R. , Eloranta Sandra , Samuelsson Jan , Landgren Ola , Dickman Paul W. , Lambert Paul C. , Björkholm Magnus 
Published: June 2015

Purpose Myeloproliferative neoplasms (MPNs) are associated with a shortened life expectancy. We assessed causes of death in patients with MPN and matched controls using both relative risks and absolute probabilities in the presence of competing risks. Patients and Methods From Swedish registries, we identified 9,285 patients with MPN and 35,769 matched controls. A flexible parametric model was used to estimate cause-specific hazard ratios (HRs) of death and cumulative incidence functions, each with 95% CIs. Results In patients with MPN, the HRs of death from hematologic malignancies and infections were 92.8 (95% CI, 70.0 to 123.1) and 2.7 (95% CI, 2.4 to 3.1), respectively. In patients age 70 to 79 years at diagnosis (the largest patient group), the HRs of death from cardiovascular and cerebrovascular disease were 1.5 (95% CI, 1.4 to 1.7) and 1.5 (95% CI, 1.3 to 1.8), respectively; all were statistically significantly elevated compared with those of controls. In the same age group, no difference was observed in the 10-year probability of death resulting from cardiovascular disease in patients with MPN versus controls (16.8% v 15.2%) or cerebrovascular disease (5.6% v 5.2%). In patients age 50 to 59 years at diagnosis, the 10-year probability of death resulting from cardiovascular and cerebrovascular disease was elevated, 4.2% versus 2.1% and 1.9% versus 0.4%, respectively. Survival in patients with MPN increased over time, mainly because of decreased probabilities of dying as a result of hematologic malignancies, infections, and, in young patients, cardiovascular disease. Conclusion Patients with MPN had an overall higher mortality rate than that of matched controls, primarily because of hematologic malignancy, infections, and vascular events in younger patients. Evidently, there is still a need for effective disease-modifying agents to improve patient outcomes.
Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapies
Authors: Lasserre Jean-Paul , Dautant Alain , Aiyar Raeka S. , Kucharczyk Roza , Glatigny Annie , Tribouillard-Tanvier Déborah , Rytka Joanna , Blondel Marc , Skoczen Natalia , Reynier Pascal , Pitayu Laras , Rötig Agnès , Delahodde Agnès , Steinmetz Lars M. , Dujardin Geneviève , Procaccio Vincent , di Rago Jean-Paul 
Published: June 2015

ABSTRACTMitochondrial diseases are severe and largely untreatable. Owing to the many essential processes carried out by mitochondria and the complex cellular systems that support these processes, these diseases are diverse, pleiotropic, and challenging to study. Much of our current understanding of mitochondrial function and dysfunction comes from studies in the baker's yeast Saccharomyces cerevisiae. Because of its good fermenting capacity, S. cerevisiae can survive mutations that inactivate oxidative phosphorylation, has the ability to tolerate the complete loss of mitochondrial DNA (a property referred to as ‘petite-positivity’), and is amenable to mitochondrial and nuclear genome manipulation. These attributes make it an excellent model system for studying and resolving the molecular basis of numerous mitochondrial diseases. Here, we review the invaluable insights this model organism has yielded about diseases caused by mitochondrial dysfunction, which ranges from primary defects in oxidative phosphorylation to metabolic disorders, as well as dysfunctions in maintaining the genome or in the dynamics of mitochondria. Owing to the high level of functional conservation between yeast and human mitochondrial genes, several yeast species have been instrumental in revealing the molecular mechanisms of pathogenic human mitochondrial gene mutations. Importantly, such insights have pointed to potential therapeutic targets, as have genetic and chemical screens using yeast.
The serum magnesium concentration as a potential state marker in patients with unipolar affective disorder
Authors: Styczeń Krzysztof , Siwek Marcin , Sowa-Kućma Magdalena , Dudek Dominika , Reczyński Witold , Szewczyk Bernadeta , Misztak Paulina , Topór-Mądry Roman , Opoka Włodzimierz , Nowak Gabriel 
Published: June 2015

CelRosnąca liczba danych sugeruje, że stężenie magnezu może pełnić rolę markera dużej depresji (ang. major depressive disorder – MDD), jednak wnioski płynące z badań klinicznych pozostają niejednoznaczne. Celem prezentowanego badania było przeprowadzenie oceny stężeń magnezu w surowicy krwi pacjentów z MDD (w aktywnej fazie choroby lub w remisji) oraz analiza roli poziomu magnezu jako potencjalnego markera tego schorzenia.MetodaBadanie kliniczno-kontrolne, w ramach którego przebadano 69 pacjentów w trakcie epizodu depresyjnego, 45 w remisji objawowej oraz 50 zdrowych ochotników. Pomiaru stężenia magnezu dokonano metodą płomieniowej atomowej spektrometrii absorpcyjnej (FAAS).WynikiŚrednie stężenie magnezu w surowicy krwi pacjentów, w fazie depresyjnej było statystycznie wyższe w odniesieniu do grupy kontrolnej. Poziom magnezu u pacjentów w fazie remisji nie różnił się istotnie od stężenia notowanego u zdrowych ochotników. Ponadto wykazano dodatnią korelację pomiędzy stężeniem magnezu a nasileniem depresji mierzonym Skalą Depresji Hamiltona oraz skalą Montgomery-Asberg.WnioskiUzyskane wyniki mogą sugerować rolę magnezu jako markera stanu, odzwierciedlającego patofizjologiczne zmiany leżące u podłoża MDD i towarzyszące ciężkim epizodom depresyjnym.