bluuebunny/crossref_metadata_2025_split huggingface dataset:
Socioeconomic status moderate the relationship between mental health literacy, social participation, and active aging among Chinese older adults: Evidence from a moderated network analysis
Authors: Huang Yalian , Zhou Aibao , Tang Ping , Ma Xufeng 
Published: August 2024

Abstract

Objective
Population aging presents a significant global challenge, with China's population aging at an accelerated rate. Several studies have established a directional link between mental health literacy, social participation, and active aging, though the moderating effect of socioeconomic status (SES) on this relationship remains unclear. Previous literature primarily utilized total score analyses, prompting this study to address the gap through moderated network analysis.
Methods
A cross-sectional design was employed with a sample of 1032 Chinese elders (age ≥ 60) who completed the Mental Health Literacy Questionnaire, Active Aging Scale, Social Participation Questionnaire, and Socioeconomic Status Index Scale. The moderated network approach was utilized to examine the bidirectional relationships among mental health literacy, social participation, and active aging, alongside the moderating role of SES.
Results
The analysis revealed that the strongest bidirectional relationships were between attitudes toward mental illnesses and developing spiritual wisdom. The number of interaction terms among mental health literacy, social participation, and active aging moderated by SES was seven. Additionally, the most significant interaction terms were between attitudes toward mental illnesses and engaging in active learning.
Conclusions
These findings offer new evidence on the bidirectional relationships among mental health literacy, social participation, and active aging, as well as the interaction terms moderated by SES. They provide pivotal theoretical and practical insights, underscoring the necessity for comprehensive policy measures addressing socioeconomic disparities in later life to promote active aging.
In-Situ Synthesis of Nickel Nanoparticles in Olive Oil and Study of Their Tribological Properties as Vegetable Oil Additives
Authors: Xu Wenya , Yang Guangbin , Zhang shengmao , Zhang Yujuan , Fan Shuguang , Yu Laigui , Zhang Pingyu 
Published: August 2024

Abstract

Vegetable oil-based lubricants have a tendency to replace traditional petroleum based lubricants due to their biodegradability, high flash point, low volatility, and low cost. However, polar molecules such as fatty acids in vegetable oil compete for adsorption with nanoparticles during rubbing process, resulting in imperfect tribological performance of nanoparticles. Magnetic nanoadditives can be adsorbed on the contact surface of iron-based friction materials through magnetic effects, which provides a new idea for solving competitive adsorption problems between additives and base oil. In this study, Ni nanoparticles with a particle size of approximately 15.6 nm were synthesized in situ in olive oil using nickel acetylacetone as the nickel source and olive oil as the modifier and solvent required for the reaction, which is a simple, efficient, and environmentally friendly in-situ synthesis method. The as-synthesized Ni nanoparticles can significantly improve the antiwear capabilities of olive oil, reducing the wear scar diameter by 30%. The morphology and elemental analysis of wear scar indicated that a composite tribofilm including nickel, nickel oxide, iron oxide, carbon film, and polar fatty acid molecules in olive oil is formed on the rubbing surface, greatly improving the antiwear performance, which opens up an opportunity for the further application of new green nanolubricants.
Coronil biochemically inhibits the interaction of various clinically relevant mutants of SARS-CoV-2 Spike Proteins (Omicron Variants) with human ACE2 receptor
Authors: Balkrishna Acharya , Dev Rishabh , Kumar Sandeep , Varshney Anurag 
Published: August 2024

Abstract

Background Accumulating evidence suggests that the receptor binding domain (RBD) of the SARS-CoV-2 Omicron variant has several times more binding affinity to the human angiotensin-converting enzyme 2 (ACE2) receptor compared to the RBD of the original covid-19 strain This increased binding affinity of Omicron variant is responsible for its increased internalization and infectivity.Methods In the present study, the impact of Coronil, a tri-herbal formulation of extracts from Withania somnifera, Tinospora cordifolia, and Ocimum sanctum on the binding properties of Omicron SARS-CoV-2 variant spike proteins (S proteins) was investigated. Compositional analysis of Coronil was performed by the Prominence-XR UHPLC system. The ELISA-based ACE2 binding inhibition assay was performed to delineate the effect of Coronil on the interaction between human ACE2 receptor and different Omicron variant spike proteins such as BA.4/BA5, XBB, BA.2.75.2, BA4.6/BF.7, BA.2.75.2, BQ.1.1, and a recently found spike protein variant JN.1 which is thought to emerge from BA.2.86.Results Coronil showed a dose-dependent inhibitory effect on the interactions between ACE2 and receptor binding domains (RBD) of all variants of spike proteins evaluated in this study including the recently emerged, highly transmissible variant spike protein JN.1. Although, Coronil significantly reduced the binding percentage in almost all the variant spike proteins, the maximum inhibition was achieved against BA.4/BA.5 where it inhibited the S protein – ACE2 interaction even at a low concentration of 3 µg/ml (16.6%). This binding inhibition was further increased to 60.3 and 84.6% at 100 and 300 µg/ml respectively.Conclusions This capability of Coronil to inhibit the binding of spike protein variants with ACE2 receptor may interfere with viral binding and internalization resulting in reduced infectivity of these Omicron spike protein variants. Overall, our data underscores the potential of Coronil in combating the various newly emerged Omicron spike protein variants. These findings may provide a basis for further studies of Coronil for its clinical effectiveness against these Omicron variants.
Longitudinal growth of the Saccharina kelp embryo depends on actin filaments that control the formation of a corset of alginate
Authors: Boscq Samuel , Theodorou Ioannis , Milstein Roman , Bail Aude Le , Chenivesse Sabine , Billoud Bernard , Charrier Bénédicte 
Published: August 2024

Abstract

The initiation of embryogenesis in the kelp Saccharina latissima is accompanied by significant anisotropy in cell shape. Using monoclonal antibodies, we show that this anisotropy coincides with a spatio-temporal pattern of accumulation of alginates in the cell wall of the zygote and embryo. Alginates rich in guluronates as well as sulphated fucans show a homogeneous distribution in the embryo throughout Phase I of embryogenesis, but mannuronate alginates accumulate mainly on the sides of the zygote and embryo, disappearing as the embryo enlarges at the start of Phase II. This pattern depends on the presence of cortical actin filaments. In contrast, within the embryo lamina, the alginate composition of the walls newly formed by cytokinesis is not affected by the depolymerisation of actin filaments. Thus, in addition to revealing the existence of a mannuronate-rich alginate corset that may restrict the enlargement of the zygote and the embryo, thereby promoting the formation of the apico-basal growth axis, we demonstrate stage-and cytoskeleton-dependent differences in cell wall deposition in Saccharina embryos.
Explaining the adaptation gap in European cities
Authors: Reckien Diana , Buzási Attila , Olazabal Marta , Fokaides Paris , Pietrapertosa Filomena , Eckersley Peter , Salvia Monica 
Published: August 2024

Abstract

An adaptation gap exists when adaptation efforts fail to meet adaptation needs. Conceptualizing and operationalizing this gap is challenging, but should start with, as we argue, addressing ‘internal adaptation policy consistency’. Through a comprehensive European study of local adaptation planning and its progress, we demonstrate how consistency checks applied to adaptation plans can conceptually and methodologically advance understanding of the adaptation (implementation) gap and, most importantly, how to reduce it.
Neutrophil-to-lymphocyte ratio doesn’t predict short-term mortality, cardiac injury or left ventricular dysfunction after cardiac surgery
Authors: Enev Rostislav 
Published: August 2024

Abstract

Introduction: The neutrophil-to-lymphocyte ratio (NLR) has been suggested as a potential biomarker for predicting adverse outcomes in various cardiovascular conditions. However, its utility in predicting short-term mortality, cardiac injury, or dysfunction following cardiac surgery remains unclear. This study aims to evaluate the relationship between NLR and these outcomes in patients undergoing cardiac surgery.
Materials and Methods: A retrospective analysis was conducted on 75 patients who underwent cardiac surgery. The NLR was calculated pre- and postoperatively for each patient. NLR dynamics was calculated based on pre-and postop values. Outcomes of interest included in-hospital mortality, significant cardiac injury indicated by elevated creatine kinase-MB (CK-MB) levels, and significant new onset left ventricular dysfunction defined as a marked decrease in left ventricular ejection fraction (EF). Statistical analyses were performed to compare NLR valuse between patients who did and did not experience these adverse outcomes.
Results: Data analysis showed no significant difference in the mean preop, postop and NLR dynamics between patients who died during hospitalization and those who survived. Similarly, the mean NLR did not significantly differ between patients with and without significant elevations in CK-MB levels or between those with stable versus decreased EF. No significant correlation was found between NLR values and studied outcomes.
Conclusion: These findings suggest that the neutrophil-to-lymphocyte ratio is not a reliable predictor of short-term mortality, cardiac injury, or left ventricular dysfunction in patients following cardiac surgery. Further research should focus on identifying more effective biomarkers for these critical outcomes.
Sµ-3’RRrecHigh Chronic Lymphocytic Leukemia is associated with specific gene expression signature, activation-induced cMYC expression and sustained cell cycle entry.
Authors: Milène Parquet , Kenza Guiyedi , Justine Pollet , Israa Al Jamal , Maxime Roubinet , Jasmine Chauzeix , Mélanie Boulin , David Rizzo , Jean Feuillard , Nathalie Gachard , Sophie Peron 
Published: August 2024

Abstract

Chronic lymphocytic leukemia (CLL) is an indolent non-Hodgkin B-cell lymphoma and is still incurable. In a previous study of CLL patients, the IGH locus DNA recombination between the switch µ (Sµ) and one 3’ regulatory regions (3’RR), the Sµ-3’RRrec, was detected more frequently than in normal condition. As a reminder, the Sµ-3'RRrec has been repeatedly detected in B-cells of mice and humans and is expected to induce cell death. Sµ-3’RRrec appears to be a rare event in normal B-cells. The Sµ-3’RRrecHighCLLs harboring high count of Sµ-3’RRrec junctions in DNA from blood samples has been characterized as a poor prognosis group with increasedMYCexpression. In these cases, the increase in Sµ-3'RRrec probably reflects ongoing recombination activity. In order to deepen the molecular basis involved in the IGH recombination process underway in Sµ-3'RRrecHighCLL, we further characterized how the patient groups differ. Our results provide additional features suggesting distinct cellular response to BCR stimulation, different cell signaling and non comparable cell cycle dynamics. Briefly, the Sµ-3'RRrecHighsamples appear to retain the ability to respond to BCR stimulation, resulting in increased c-MYC expression and to fast cell cycle entry. Whereas Sµ-3'RRrecLowCLLs appear to show a lesser response to BCR stimulation and increasedBcl2transcripts in lymph nodes that could contribute to a more indolent disease. This latter is probably associated with an attenuated genetic recombination activity. Whereas this latter must be exacerbated in condition of more intense proliferation due to MYC in Sµ-3'RRrecHighCLL.
Antibiotic resistance ofE. coliisolates from different water sources in Mbarara, Uganda
Authors: Catherine N. Abaasa , Claudia Stange , Savino Ayesiga , Edgar Mulogo M. , Rogers Kalyetsi , Julius Lejju B. , Morgan Andama , Imelda Tamwesigire K. , Joel Bazira , Frederick Byarugaba , Andreas Tiehm 
Published: August 2024

ABSTRACTEscherichia coli is widely used as an indicator of recent faecal pollution of water. Most E. coli strains are commensals; however, isolates in water samples have been shown to carry antibiotic resistance determinants. In total, 47 E. coli were isolated from selected drinking water sources in Mbarara, Uganda. The isolates were examined for their susceptibility to seven antibiotics and the presence of nine antibiotic-resistance genes (mostly β-lactamase genes) and class 1 integrons. Isolates showed a high resistance to ampicillin of 55.5% and a high sensitivity to azithromycin and gentamicin at 98 and 96%, respectively. PCR analysis showed the presence of extended-spectrum β-lactamase genes blaCTX-M-32 and blaCMY-2 in 64 and 36% of the isolates. The carbapenemase genes blaOXA-48, blaVIM-2, blaNDM-1, and blaKPC-3 were either not detected or only in a very small number of the isolates, whereas class 1 integrons were present in 68% of the isolates. This study proves that antimicrobial resistance exists in E. coli in water used for drinking purposes in Mbarara city. There is a need for public health actors to improve the surveillance of microbiological quality of drinking water to minimize health risks.
Balancing Between Privacy and Utility for Affect Recognition Using Multitask Learning in Differential Privacy–Added Federated Learning Settings: Quantitative Study
Authors: Benouis Mohamed , Andre Elisabeth , Can Yekta Said 
Published: August 2024

Abstract

Background
The rise of wearable sensors marks a significant development in the era of affective computing. Their popularity is continuously increasing, and they have the potential to improve our understanding of human stress. A fundamental aspect within this domain is the ability to recognize perceived stress through these unobtrusive devices.

Objective
This study aims to enhance the performance of emotion recognition using multitask learning (MTL), a technique extensively explored across various machine learning tasks, including affective computing. By leveraging the shared information among related tasks, we seek to augment the accuracy of emotion recognition while confronting the privacy threats inherent in the physiological data captured by these sensors.

Methods
To address the privacy concerns associated with the sensitive data collected by wearable sensors, we proposed a novel framework that integrates differential privacy and federated learning approaches with MTL. This framework was designed to efficiently identify mental stress while preserving private identity information. Through this approach, we aimed to enhance the performance of emotion recognition tasks while preserving user privacy.

Results
Comprehensive evaluations of our framework were conducted using 2 prominent public datasets. The results demonstrate a significant improvement in emotion recognition accuracy, achieving a rate of 90%. Furthermore, our approach effectively mitigates privacy risks, as evidenced by limiting reidentification accuracies to 47%.

Conclusions
This study presents a promising approach to advancing emotion recognition capabilities while addressing privacy concerns in the context of empathetic sensors. By integrating MTL with differential privacy and federated learning, we have demonstrated the potential to achieve high levels of accuracy in emotion recognition while ensuring the protection of user privacy. This research contributes to the ongoing efforts to use affective computing in a privacy-aware and ethical manner.
Association of Kidney Function with Sodium-Glucose Co-Transporter 2 Inhibitor Discontinuation among US Veterans
Authors: Ikeme Jesse C. , Madden Erin , Lamprea-Montealegre Julio A. , Chu Chi D. , Shlipak Michael G. , McCoy Ian E. , Estrella Michelle M. 
Published: August 2024

Key Points

Patients started on sodium-glucose co-transporter-2 inhibitors (SGLT2i) had a 23% risk of discontinuation at 1 year; 41% of these discontinuations occurred within the first 3 months.Patients with lower kidney function were more likely to experience discontinuation.Higher rates of SGLT2i discontinuation in patients with CKD may limit the cardiokidney benefits of SGLT2i in real-world practice.

Background
The effect of sodium-glucose co-transporter-2 inhibitors (SGLT2i) on cardiovascular disease and CKD may be limited if discontinued in persons with CKD. We sought to determine whether CKD at SGLT2i initiation was associated with subsequent discontinuation.

Methods
This cohort study used electronic health record data of patients who initiated SGLT2i in the Veterans Health Administration from January 2017 through December 2021. The primary exposure was eGFR category at the time of SGLT2i initiation. The risk of SGLT2i discontinuation, defined by a provider order or expiration of an SGLT2i prescription without resumption in the following 180 days, was estimated using proportional hazards models with inverse probability weights for censoring due to death. Analyses were stratified by year of SGLT2i initiation.

Results
Among the 222,772 patients initiating an SGLT2i during the study period, the median age was 68 (interquartile range, 60–73) years, 95% were male, and median (interquartile range) eGFR was 73 (58–89) ml/min per 1.73 m2. Median follow-up was 1.6 years; 32% experienced SGLT2i discontinuation. Cumulative risk of discontinuation at 1 year was 21%–27% across calendar years; approximately 41% of these discontinuations occurred within the first 3 months. There was a graded association between lower baseline eGFR and greater risk of discontinuation; this association attenuated across calendar years. Those initiating an SGLT2i in 2017 with baseline eGFR of 45–59 and 30–44 had 1.34- (95% confidence interval [CI], 1.21 to 1.49) and 2.04-fold (95% CI, 1.58 to 2.63) risks of discontinuation, respectively, compared with those with eGFR ≥60 ml/min per 1.73 m2. These hazard ratios reduced to 1.05 (95% CI, 1.02 to 1.10) and 1.20 (95% CI, 1.14 to 1.26), respectively, in those initiated in 2021.

Conclusions
A substantial proportion of patients experience SGLT2i discontinuation within a year of initiation. Those with lower eGFR had higher discontinuation rates; however, this trend attenuated over time. Additional studies identifying and addressing factors leading to discontinuation are needed to fully realize the benefits of SGLT2i.

Podcast
This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2024_11_26_CJASNNov1911112624.mp3
H. pylori-Associated Gastritis, Gastritis after H. pylori Eradication and H. pylori-Negative Gastritis: Algorithm of Diagnosis and Treatment (Literature Review and Resolution of the Expert Panel of the Russian Gastroenterological Association)
Authors: Ivashkin V. T. , Maev I. V. , Lapina T. L. , Kucheryavyy Yu. A. , Abdulkhakov S. R. , Alekseeva O. P. , Alekseenko S. A. , Andreev D. N. , Bakulin I. G. , Bakulina N. V. , Bordin D. S. , Galeeva Z. M. , Dekhnich N. N. , Korochanskaya N. V. , Kuvaev R. O. , Livzan M. A. , Osipenko M. F. , Pirogov S. S. , Simanenkov V. I. , Storonova O. A. , Tertychnyy A. S. , Trukhmanov A. S. , Uspenskiy Yu. P. , Khlynov I. B. , Tsukanov V. V. 
Published: August 2024

Aim: to provide the basic points of the Expert Panel of the Russian Gastroenterological Association with discussion of measures to improve diagnostics, treatment and management of chronic gastritis patients.Key points. In the Russian Federation in 2021 more than 30 million patients diagnosed with “Gastritis and duodenitis” were recorded (K29 in accordance with International Classification of Diseases-10). H. pylori incidence rate in the Russian population has reduced and presently is about 40 %. In chronic gastritis pattern H. pylori-associated gastritis has still dominated though gastritis percent after successful H. pylori eradication, reactive gastropathy (including reflux gastritis) and autoimmune gastritis, has increased. Endoscopic and histologic examinations serve as key diagnostic techniques that provide a means for assessing the ethiology of gastritis, topography and degree of atrophic changes, gastritis staging as per OLGA/OLGIM system that properly correlates with the risk of stomach cancer and determines endoscopic examination strategy. H. pylori eradication therapy of gastritis serves as an etiotropic treatment and makes it possible to prevent progression of atrophy and stomach cancer. Conventional triple therapy combined with bismuth tripotassium dicitrate allows for achieving optimal cure rates of H. pylori eradication. Addition of rebamipide to regimens of H. pylori eradication improves their efficiency. Rebamipide arrests symptoms of dyspepsia in the case of chronic gastritis and functional dyspepsia. The administration of rebamipide for chronic gastritis makes it possible to influence the syndrome of increased epithelial permeability and inflammation, which makes it advisable to study it as a means of preventing stomach cancer and the progression of atrophy in various types of chronic gastritis.Conclusion. Members of the Expert Panel has approved the algorithm of diagnosis and treatment of H. pylori-associated gastritis, gastritis after H. pylori eradication and H. pylori-negative gastritis at the diagnostic stage in the case of initial presentation and long-term follow-up when needed.
Prospek Nahdlatul Ulama dan Muhammadiyah Menuju Penyatuan Kalender Islam di Indonesia
Authors: Wiwik Wiwik Triulan , Kurniati  , Marilang  
Published: August 2024

Dilatarbelakangi adanya problem keagamaan terkait perbedaan ormas Islam dalam metode penetapan awal bulan hijriah antara Nahdlatul Ulama (imkanrukyat) dan Muhammadiyah (wujudul hilal). Penelitian ini bertujuan untuk menganalisis prospek Nahdlatul Ulama dan Muhammadiyah dalam Penyatuan Kalender Islam di Indonesia. Metode penelitian ini kajian pustaka atau Library research dengan pendekatan hukum Islam dan astronomi. Berdasarkan metode yang ada maka upaya penyatuan dilakukan baik skala nasional maupun internasional, diperlukan adanya mekanisme yang jelas, terarah, dan secara bersama-sama menyatukan langkah untuk mewujudkan kalender Islam di Indonesia. Untuk itu tawaran penggunaan kalender yang diusulkan yaitu kalender Uhadi (kalender Islam unifikasi) dan kalender Tawlifi (kalender Islam Sintesa). Dengan adanya kalender yang disepakati diharapkan menjadi jalan terbaik tanpa memenangkan atau mengalahkan satu pihak dan tetap menjaga ukhwah Islamiyah di Indonesia. Penelitian ini memiliki keterbatasan sehingga diharapkan kepada peneliti selanjutnya untuk melengkapi kekurangan dan mengembangkan penelitian ini.
Insuficiencia renal crónica y sus posibles soluciones en Colombia
Authors: Roso Alfredo Cala Hederich  
Published: August 2024

Colombia Medica entrevista a:
Roso Alfredo Cala Hederich, M.D.
Internista-Nefrólogo. Profesor Titular de Medicina Interna, Nefrología. Facultad de Salud, Universidad Industrial de Santander, UIS, Bucaramanga. Ex-Decano de la Facultad de Salud de la UIS, Bucaramanga. Director del Programa de Transplante Renal y Jefe de la Unidad de Nefrología, Hospital Universitario Ramón González Valencia, Bucaramanga. Ex-Presidente de la Asociación Colombiana de Medicina Interna y de la Sociedad Colombiana de Nefrología. Miembro de Número de la Academia Nacional de Medicina.