bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diffusion‐weighted imaging for evaluation of uterine arterial embolization of fibroids
Authors: Faye Nathalie , Pellerin Olivier , Thiam Rokhaya , Chammings Foucauld , Brisa Marie , Marques Enio , Cuénod Charles A. , Sapoval Marc , Fournier Laure S. 
Published: February 2013

PurposeTo determine whether diffusion‐weighted imaging (DWI) characteristics could predict the effectiveness of uterine arterial embolization in treatment of fibroids.MethodsThis retrospective study included 17 women (27 fibroids) who underwent uterine arterial embolization for fibroids. MR imaging (1.5 T) was performed before, 1 week and 6 months after uterine arterial embolization. The volume, T2 signal, T1 signal, enhancement after contrast media injection, DWI signal (b = 500 s/mm2) and apparent diffusion coefficient (ADC) were assessed for fibroids.ResultsDWI signal or ADC, whether before or 1 week after the procedure, did not show a statistical relationship to success of uterine arterial embolization. On the 1‐week follow‐up, 22% of fibroids enhanced vs. 85% on baseline, P < 0.0001 and DW signal intensity increased. ADC values in fibroids decreased between baseline and 1‐week (1.61 vs. 1.53 × 10−3 mm2/s, P = 0.13). On 6‐months, ADC continued to decrease compared with baseline (1.27 × 10−3 mm2/s, P = 0.002), but with a lower signal on DWI. No changes were observed in myometrium ADC at any time point.ConclusionOur study demonstrated that DWI and ADC reflected early and delayed changes in fibroids after embolization; however, we were not able to demonstrate a statistically significant relationship with outcome. Magn Reson Med 70:1739–1747, 2013. © 2013 Wiley Periodicals, Inc.
The cancer psychosocial care matrix: a community‐derived evaluative tool for designing quality psychosocial cancer care delivery
Authors: Forsythe Laura P. , Rowland Julia H. , Padgett Lynne , Blaseg Karyl , Siegel Scott D. , Dingman Chad M. , Gillis Theresa A. 
Published: February 2013

AbstractObjectiveAlthough the Institute of Medicine provided a vision for effective psychosocial care for cancer survivors, limited guidance exists regarding the essential components of comprehensive care or progressive steps for implementing each component. This paper describes the development of a unique tool for assessing capacity to provide quality psychosocial care to cancer survivors and the results of the first implementation of this tool in community settings.MethodsThe psychosocial working group of the National Cancer Institute Community Cancer Centers Program (NCCCP) developed the Cancer Psychosocial Care Matrix assessment tool. All NCCCP sites (n = 30, enrolled in 2007 and 2010) completed the matrix indicating their capacity for providing psychosocial care at entry into NCCCP (‘baseline’) after 2 years of NCCCP participation (2007 sites only) and within the coming year (‘future aspirations’).ResultsAt baseline, matrix responses reflected few or no systematic processes in place for most components of comprehensive psychosocial care. However, reported capacity to deliver specific components improved at 2 years post‐NCCCP entry for the 2007 sites and in all NCCCP sites' future aspirations.ConclusionsWith growing demand on cancer centers to meet new metrics of quality care, the psychosocial matrix can help centers systematically identify and develop steps to address gap areas in their capacity to meet these new standards. The Cancer Psychosocial Care Matrix appears to enable evaluation of psychosocial programs, may promote intentions to improve psychosocial services, and can facilitate communication of ‘best practices’ among cancer centers. Copyright © 2013 John Wiley & Sons, Ltd.
The James Supportive Care Screening: integrating science and practice to meet the NCCN guidelines for distress management at a Comprehensive Cancer Center
Authors: Wells‐Di Gregorio Sharla , Porensky Emily K. , Minotti Matthew , Brown Susan , Snapp Janet , Taylor Robert M. , Adolph Michael D. , Everett Sherman , Lowther Kenneth , Callahan Kelly , Streva Devita , Heinke Vicki , Leno Debra , Flower Courtney , McVey Anne , Andersen Barbara Lee 
Published: February 2013

AbstractBackgroundSelecting a measure for oncology distress screening can be challenging. The measure must be brief, but comprehensive, capturing patients' most distressing concerns. The measure must provide meaningful coverage of multiple domains, assess symptom and problem‐related distress, and ideally be suited for both clinical and research purposes.MethodsFrom March 2006 to August 2012, the James Supportive Care Screening (SCS) was developed and validated in three phases including content validation, factor analysis, and measure validation. Exploratory factor analyses were completed with 596 oncology patients followed by a confirmatory factor analysis with 477 patients.ResultsSix factors were identified and confirmed including (i) emotional concerns; (ii) physical symptoms; (iii) social/practical problems; (iv) spiritual problems; (v) cognitive concerns; and (vi) healthcare decision making/communication issues. Subscale evaluation reveals good to excellent internal consistency, test–retest reliability, and convergent, divergent, and predictive validity. Specificity of individual items was 0.90 and 0.87, respectively, for identifying patients with DSM‐IV‐TR diagnoses of major depression and generalized anxiety disorder.ConclusionsResults support use of the James SCS to quickly detect the most frequent and distressing symptoms and concerns of cancer patients. The James SCS is an efficient, reliable, and valid clinical and research outcomes measure. Copyright © 2013 John Wiley & Sons, Ltd.
Silicon nanocrystals from high‐temperature annealing: Characterization on device level
Authors: Löper Philipp , Canino Mariaconcetta , López‐Vidrier Julian , Schnabel Manuel , Schindler Florian , Heinz Friedemann , Witzky Anke , Bellettato Michele , Allegrezza Marco , Hiller Daniel , Hartel Andreas , Gutsch Sebastian , Hernández Sergi , Guerra Roberto , Ossicini Stefano , Garrido Blas , Janz Stefan , Zacharias Margit 
Published: February 2013

AbstractSilicon nanocrystals (Si NCs) embedded in Si‐based dielectrics provide a Si‐based high band gap material (1.7 eV) and enable the construction of all‐crystalline Si tandem solar cells. However, Si nanocrystal formation involves high‐temperature annealing which deteriorates the properties of any previously established selective contacts. The inter‐diffusion of dopants during high‐temperature annealing alters Si NC formation and limits the built‐in voltage. Furthermore, most devices presented so far also involve electrically active bulk Si and therefore do not allow a clear separation of the observed photovoltaic effect of the nanocrystal layer from that of the bulk Si substrate. A membrane route is presented for nanocrystal based p–i–n solar cells to overcome these limitations. In this approach, the formation of both selective contacts is carried out after high‐temperature annealing and therefore not affected by the latter. p–i–n Solar cells are investigated with Si NCs embedded in silicon carbide in the intrinsic region. Device failure due to damaged insulation layers is analyzed by electron‐ and light beam induced current measurements. Open‐circuit voltages of 176 mV are shown for the NC layer. An optical model of the device is presented for improving the cell current. Comparison of the optical limit and the measured short circuit current demonstrates that the device is governed by recombination within the absorber layer. magnified imageVertical p–i–n solar cell with a Si nanocrystal thin film in the intrinsic region and selective electron and hole contacts by doped amorphous silicon carbide (a‐SixC1−x:H).
Highly sensitive NO2 sensors based on local p–n heterojunctions composed of 0D CuO nanoparticles and 1D ZnO nanorods
Authors: Hoa Le Thuy , Hur Seung Hyun 
Published: February 2013

AbstractA novel and highly sensitive p–n heterojunction sensor composed of zero‐dimensional (0D) CuO nanoparticles (NPs) and one‐dimensional (1D) ZnO nanorods (NRs) was fabricated using a solution‐based process. The structures were characterized with scanning electron microscopy (SEM) and X‐ray photoelectron spectroscopy (XPS). The formation of electron depletion layers in the p‐CuO and n‐ZnO is believed to increase the adsorption of NO2, resulting in a 6‐fold response improvement and a 13‐fold increased sensitivity compared to ZnO NRs alone. We believe that this type of heterojunction device can be applied to many different sensing applications.
Nonlinear electronic transport in the anomalous metallic state of quasi‐2D organic superconductors κ‐(BEDT‐TTF)2X
Authors: Rommel R. , Hartmann B. , Brandenburg J. , Schlueter J. A. , Müller J. 
Published: February 2013

AbstractWe present measurements of the first‐ and third‐harmonic voltage response in ac electronic transport measurements, representing the linear (ohmic) and nonlinear resistivity, respectively, of the quasi‐two‐dimensional (2D) organic superconductors κ‐(BEDT‐TTF)2X. Nonlinear transport is a sensitive tool to probe the microgeometry of the electronic system in high‐quality single crystals. For the title compounds, the normalconducting metallic state in the vicinity of the Mott metal–insulator (MI) transition and critical endpoint is known to be highly unusual. Our results reveal large current‐induced intrinsic inhomogeneities, at high current densities most pronounced at the so‐called T* anomaly, which characterizes the anomalous metallic state. The observed nonlinearities in the interlayer transport do not depend on frequency and cannot be ascribed to a simple Joule heating mechanism in a resistor network. Furthermore, we find evidence supporting the notion of electronic phase separation induced by the Mott critical endpoint. The observed dependence of the generated third‐harmonic voltage on the current density reveals a systematic behavior suggesting that current‐induced electronic inhomogeneities are more pronounced for more strongly correlated systems.
A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits
Authors: Feliciano David M. , Lin Tiffany V. , Hartman Nathaniel W. , Bartley Christopher M. , Kubera Cathryn , Hsieh Lawrence , Lafourcade Carlos , O'Keefe Rachel A. , Bordey Angelique 
Published: February 2013

AbstractTuberous sclerosis complex (TSC) is an autosomal dominant monogenetic disorder that is characterized by the formation of benign tumors in several organs as well as brain malformations and neuronal defects. TSC is caused by inactivating mutations in one of two genes, TSC1 and TSC2, resulting in increased activity of the mammalian Target of Rapamycin (mTOR). Here, we explore the cytoarchitectural and functional CNS aberrations that may account for the neurological presentations of TSC, notably seizures, hydrocephalus, and cognitive and psychological impairments. In particular, recent mouse models of brain lesions are presented with an emphasis on using electroporation to allow the generation of discrete lesions resulting from loss of heterozygosity during perinatal development. Cortical lesions are thought to contribute to epileptogenesis and worsening of cognitive defects. However, it has recently been suggested that being born with a mutant allele without loss of heterozygosity and associated cortical lesions is sufficient to generate cognitive and neuropsychiatric problems. We will thus discuss the function of mTOR hyperactivity on neuronal circuit formation and the potential consequences of being born heterozygous on neuronal function and the biochemistry of synaptic plasticity, the cellular substrate of learning and memory. Ultimately, a major goal of TSC research is to identify the cellular and molecular mechanisms downstream of mTOR underlying the neurological manifestations observed in TSC patients and identify novel therapeutic targets to prevent the formation of brain lesions and restore neuronal function.
Brugada syndrome: Recent understanding of pathophysiological mechanism and treatment
Authors: Kusano Kengo F. 
Published: February 2013

AbstractSince 1992, Brugada syndrome has gained worldwide recognition as an important cause of sudden cardiac death due to ventricular fibrillation (VF) in the structurally normal heart. Its signature electrocardiography (ECG) pattern consists of ST‐segment elevation in the right precordial leads, and the pathophysiological mechanisms of this ST‐segment elevation and VF development have been reported to be closely related. However, the precise mechanisms present in Brugada syndrome patients remain unknown.Herein, we will review clinical and experimental evidence, with a focus on the current understanding of the underlying pathophysiological mechanisms of this unique ECG pattern and VF development, and describe the current strategy for management of Brugada syndrome.
Evaluating the effect of measurement error when using one or two 24 h dietary recalls to assess eating out: a study in the context of the HECTOR project
Authors: Orfanos Philippos , Knüppel Sven , Naska Androniki , Haubrock Jennifer , Trichopoulou Antonia , Boeing Heiner 
Published: February 2013

Eating out is often recorded through short-term measurements and the large within-person variability in intakes may not be adequately captured. The present study aimed to understand the effect of measurement error when using eating-out data from one or two 24 h dietary recalls (24hDR), in order to describe intakes and assess associations between eating out and personal characteristics. In a sample of 366 adults from Potsdam, Germany, two 24hDR and a FFQ were collected. Out-of-home intakes were estimated based on either one 24hDR or two 24hDR or the Multiple Source Method (MSM) combining the two 24hDR and the questionnaire. The distribution of out-of-home intakes of energy, macronutrients and selected foods was described. Multiple linear regression and partial correlation coefficients were estimated to assess associations between out-of-home energy intake and participants' characteristics. The mean daily out-of-home intakes estimated from the two 24hDR were similar to the usual intakes estimated through the MSM. The out-of-home energy intake, estimated through either one or two 24hDR, was positively associated with total energy intake, inversely with age and associations were stronger when using the two 24hDR. A marginally significant inverse association between out-of-home energy intake and physical activity at work was observed only on the basis of the two 24hDR. After applying the MSM, all significant associations remained and were more precise. Data on eating out collected through one or two 24hDR may not adequately describe intake distributions, but significant associations between eating out and participants' characteristics are highly unlikely to appear when in reality these do not exist.
RING ENDOMORPHISMS WITH LARGE IMAGES
Authors: LEROY ANDRÉ , MATCZUK JERZY 
Published: February 2013

AbstractThe notion of ring endomorphisms having large images is introduced. Among others, injectivity and surjectivity of such endomorphisms are studied. It is proved, in particular, that an endomorphism σ of a prime one-sided noetherian ringRis injective whenever the image σ(R) contains an essential left idealLofR. If, in addition, σ(L)=L, then σ is an automorphism ofR. Examples showing that the assumptions imposed onRcannot be weakened toRbeing a prime left Goldie ring are provided. Two open questions are formulated.
GENERATORS OF THE EISENSTEIN–PICARD MODULAR GROUP IN THREE COMPLEX DIMENSIONS
Authors: XIE BAOHUA , WANG JIEYAN , JIANG YUEPING 
Published: February 2013

AbstractLittle is known about the generators system of the higher dimensional Picard modular groups. In this paper, we prove that the higher dimensional Eisenstein–Picard modular groupPU(3, 1;ℤ[ω3]) in three complex dimensions can be generated by four given transformations.
Sustaining livelihoods around community forests. What is the potential contribution of wildlife domestication?
Authors: Buchenrieder Gertrud , Balgah Roland Azibo 
Published: February 2013

ABSTRACTCommunity forest management is often advanced as a remedy for failing top-down approaches to nature conservation. Contingent on the property rights theory, it assumes that local participation in natural resource management results in sustainable structures. There is, however, insufficient empirical evidence on the intra-community dynamics – especially when households have unequal access to the local institutions managing the natural resource. This paper looks at the socio-cultural, economic and institutional situation of households with and without access to management institutions in communities around the Kilum-Ijim Mountain Forest in Cameroon and analyses whether livelihood differences are associated with variations in management patterns. The analysis reveals differences by household type and a mixed picture of the evolution of species in the community forests over time, questioning the role of the community in natural resource conservation. Furthermore, the paper discusses the potentials of wildlife domestication for livelihoods and conservation in forest communities. The results are important in the light of ongoing conservation efforts in natural resource hot-spots in sub-Saharan Africa.
BioJS: an open source JavaScript framework for biological data visualization
Authors: Gómez John , García Leyla J. , Salazar Gustavo A. , Villaveces Jose , Gore Swanand , García Alexander , Martín Maria J. , Launay Guillaume , Alcántara Rafael , del-Toro Noemi , Dumousseau Marine , Orchard Sandra , Velankar Sameer , Hermjakob Henning , Zong Chenggong , Ping Peipei , Corpas Manuel , Jiménez Rafael C. 
Published: February 2013

Abstract
Summary: BioJS is an open-source project whose main objective is the visualization of biological data in JavaScript. BioJS provides an easy-to-use consistent framework for bioinformatics application programmers. It follows a community-driven standard specification that includes a collection of components purposely designed to require a very simple configuration and installation. In addition to the programming framework, BioJS provides a centralized repository of components available for reutilization by the bioinformatics community.
Availability and implementation: http://code.google.com/p/biojs/.
Contact: rafael@ebi.ac.uk
Supplementary information: Supplementary data are available at Bioinformatics online.
Uncoupling protein‐2 gene polymorphisms are associated with obesity in Hungarian children
Authors: Csernus K , Pauler G , Erhardt E , Lanyi E , Molnar D 
Published: February 2013

AbstractAimTo determine the frequency of common polymorphisms of genes associated with energy metabolism among normal weight and overweight/obese children to look for effects on childhood obesity.MethodsAmong 709 overweight/obese and 637 normal weight children (age 6–17 years), anthropometric measurements were carried out and genotyping for the following gene polymorphisms: β3‐adrenoreceptor Trp64Arg, uncoupling protein (UCP) ‐1 –3826 A/G, UCP‐2 –866 G/A and exon 8 del/ins, UCP‐3 –55 C/T and peroxisome proliferator‐activated receptor‐γ Pro12Ala.ResultsOn multivariate regression analysis adjusted for age and gender heterozygosity and homozygosity for the UCP‐2 –866 A variant was associated with an odds ratio (OR) for obesity of 0.69 (95% CI: 0.52–0.92; p = 0.013) and 0.50 (95% CI: 0.32–0.79; p = 0.003), respectively, compared with G/G homozygotes. Heterozygotes and homozygotes for the UCP‐2 exon 8 ins allele had an OR for obesity of 1.66 (95% CI: 1.24–2.23; p = 0.001) and 2.12 (95% CI: 1.23–3.63; p = 0.006), respectively, compared with del/del homozygotes. There were no significant differences in obesity risk in association with the other examined gene polymorphisms.ConclusionCommon polymorphisms of the UCP‐2 gene might influence the propensity to overweight/obesity in Hungarian children.
Advances in the understanding of Barth syndrome
Authors: Aprikyan Andranik A. , Khuchua Zaza 
Published: February 2013

SummaryBarth syndrome (BTHS) is an X‐linked autosomal recessive disorder characterized by neutropenia, cardiomyopathy and growth retardation. BTHS was first described as mitochondrial disease affecting neutrophils as well as cardiac and skeletal muscles. Patients with neutropenia may have extremely low levels of circulating neutrophils and suffer from recurring sometimes life‐threatening bacterial infections. Sepsis is not infrequent, may occur unexpectedly in a patient with no history for pronounced bacterial infections and may lead to death. The reduced level of circulating neutrophils suggests either a reduced production of myeloid cells in the bone marrow and premature apoptosis or aberrant clearance of neutrophils in peripheral blood. The underlying molecular defects are truncation, deletion or substitution mutations in the TAZ gene that appear to result in loss‐of‐function of the gene product tafazzin. Molecular mechanisms triggering neutropenia and cardiomyopathy in BTHS remain largely unclear. The current review focusses on recent advances in the understanding of molecular and cellular bases of neutropenia in Barth syndrome and covers the functional implications of the TAZ mutations, experimental models for neutropenia, the specific cellular abnormalities triggered by loss of TAZ function and potential novel therapeutic strategies for restoring the normal phenotype.
Individualization of tacrolimus dosage basing on cytochrome P450 3A5 polymorphism – a prospective, randomized, controlled study
Authors: Chen Si‐Yang , Li Jia‐Li , Meng Fan‐Hang , Wang Xue‐Ding , Liu Tao , Li Jun , Liu Long‐Shan , Fu Qian , Huang Min , Wang Chang‐Xi 
Published: February 2013

AbstractWe investigated how cytochrome P450 (CYP) 3A5 polymorphism affects pharmacokinetics of tacrolimus and its interaction with diltiazem in Chinese kidney transplant recipients. Sixty‐two CYP3A5 expressers and 58 non‐expressers were, respectively, randomized to receive diltiazem supplement or not. Their pharmacokinetic profiles were acquired on 14th day, sixth month, and 18th month post‐transplant and compared among groups. A dosing equation was fit based on above data with CYP3A5 genotype and diltiazem co‐administration as variables. Then, necessary initial doses with or without diltiazem were calculated and used in 11 CYP3A5 expressers, respectively, when another 11 expressers received routine doses as control. Trough concentration was measured on the third‐day post‐transplant and patients failed to reach target range were presented in percentage. These two parameters were compared among three groups. Patients were followed up until June 2010, kidney function, biopsy‐proved acute rejection, and other adverse events were monitored. Results showed that CYP3A5 expressers needed more tacrolimus to reach therapeutic concentration window and were more susceptible to diltiazem‐induced concentration increase than CYP3A5 non‐expressers. CYP3A5 polymorphism‐guided dosing equation helped to determine appropriate initial doses of tacrolimus in individuals. In conclusion, CYP3A5 polymorphism profoundly influences pharmacokinetics of tacrolimus and helps to individualize tacrolimus dose.