bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antidepressant medication use and trajectories of fasting plasma glucose, glycated haemoglobin, β-cell function and insulin sensitivity: a 9-year longitudinal study of the D.E.S.I.R. cohort
Authors: Azevedo Da Silva Marine , Dugravot Aline , Balkau Beverley , Roussel Ronan , Fumeron Frédéric , Elbaz Alexis , Canonico Marianne , Singh-Manoux Archana , Nabi Hermann ,   the D.E.S.I.R. Study Group
Published: August 2015

Abstract
Background : Use of antidepressants is seen to be a risk factor for type 2 diabetes, even though the underlying mechanisms remain unclear. We examined whether antidepressant use was associated with change in fasting plasma glucose, glycated haemoglobin (HbA1c), β-cell function (HOMA2-%B) and insulin sensitivity (HOMA2-%S) over time.
Methods : Participants in the French D.E.S.I.R. cohort study included over 4700 men (48.1%) and women, free of diabetes, aged 30–65 years at baseline in 1994–96 (D.E.S.I.R. 0), who were followed for 9 years at 3-yearly intervals (D.E.S.I.R. 3, 1997–99; 6, 2000–02; 9, 2003–05). Antidepressant use, fasting plasma glucose, HbA1c, HOMA2-%B and HOMA2-%S were assessed concurrently at four medical examinations. Linear mixed models were used to examine the cross-sectional and longitudinal associations of time-dependent antidepressant use with changes in these four biological parameters.
Results : Mean fasting plasma glucose and HbA1c increased whereas HOMA2-%B and HOMA2-%S decreased over the follow-up. In a fully adjusted model, there were no differences in: mean fasting plasma glucose ( β  = 0.01 mmol/l, P  = 0.702); HbA1c ( β  = 0.01 %, P  = 0.738); HOMA2-%B ( β  = 0.00, P  = 0.812); or HOMA2-%S ( β  =−0.01, P  = 0.791) at baseline (1994–96) between antidepressant users and non-users. The interaction term with time also suggested no differences in the annual change in: fasting plasma glucose ( β  = 0.00 mmol/l, P  = 0.322); HbA1c ( β  = 0.00 %, P  = 0.496); HOMA2-%B ( β  = 0.00, P  = 0.609); or HOMA2-%S ( β  = 0.00, P  = 0.332) between antidepressant users and non-users. Similar associations were observed in analyses of type and cumulative use of antidepressants over follow-up.
Conclusion : Our longitudinal data show that use of antidepressants is not associated with altered glucose metabolism, suggesting that the association between antidepressant use and diabetes reported by previous studies may not be causal. Detection bias or clinical ascertainment bias may account for much of this apparent association.
Case-Based Review: newly diagnosed
glioblastoma
Authors: Johnson Derek R. , Fogh Shannon E. , Giannini Caterina , Kaufmann Timothy J. , Raghunathan Aditya , Theodosopoulos Philip V. , Clarke Jennifer L. 
Published: August 2015

Abstract
Glioblastoma (WHO grade IV astrocytoma) is the most common and most aggressive primary brain tumor in adults. Optimal treatment of a patient with glioblastoma requires collaborative care across numerous specialties. The diagnosis of glioblastoma may be suggested by the symptomatic presentation and imaging, but it must be pathologically confirmed via surgery, which can have dual diagnostic and therapeutic roles. Standard of care postsurgical treatment for newly diagnosed patients involves radiation therapy and oral temozolomide chemotherapy. Despite numerous recent trials of novel therapeutic approaches, this standard of care has not changed in over a decade. Treatment options under active investigation include molecularly targeted therapies, immunotherapeutic approaches, and the use of alternating electrical field to disrupt tumor cell division. These trials may be aided by new insights into glioblastoma heterogeneity, allowing for focused evaluation of new treatments in the patient subpopulations most likely to benefit from them. Because glioblastoma is incurable by current therapies, frequent clinical and radiographic assessment is needed after initial treatment to allow for early intervention upon progressive tumor when it occurs.
Optomechanical interfaces for hybrid quantum networks
Authors: Dong Chunhua , Wang Yingdan , Wang Hailin 
Published: August 2015

Abstract
Recent advances on optical control of mechanical motion in an optomechanical resonator have stimulated strong interests in exploring quantum behaviors of otherwise classical, macroscopic mechanical systems and especially in exploiting mechanical degrees of freedom for applications in quantum information processing. In an optomechanical resonator, an optically- active mechanical mode can couple to any of the optical resonances supported by the resonator via radiation pressure. This unique property leads to a remarkable phenomenon: mechanically-mediated conversion of optical fields between vastly different wavelengths. The resulting optomechanical interfaces can play a special role in a hybrid quantum network, enabling quantum communication between disparate quantum systems. In this review, we introduce the basic concepts of optomechanical interactions and discuss recent theoretical and experimental progresses in this field. A particular emphasis is on taking advantage of mechanical degrees of freedom, while avoiding detrimental effects of thermal mechanical motion.
Genome-Wide Scan for Adaptive Divergence and Association with Population-Specific Covariates
Authors: Gautier Mathieu 
Published: August 2015

ABSTRACTIn population genomics studies, accounting for the neutral covariance structure across population allele frequencies is critical to improve the robustness of genome-wide scan approaches. Elaborating on the BayEnvmodel, this study investigates several modeling extensions i) to improve the estimation accuracy of the population covariance matrix and all the related measures; ii) to identify significantly overly differentiated SNPs based on a calibration procedure of the XtX statistics; and iii) to consider alternative covariate models for analyses of association with population-specific covariables. In particular, the auxiliary variable model allows to deal with multiple testing issues and, providing the relative marker positions are available, to capture some Linkage Disequilibrium information. A comprehensive simulation study was carried out to evaluate the performances of these different models. Also, when compared in terms of power, robustness and computational efficiency, to five other state-of-the-art genome scan methods (BayEnv2, BayScEnv, BayScan, FLK and LFMM) the proposed approaches proved highly effective. For illustration purpose, genotyping data on 18 French cattle breeds were analyzed leading to the identification of thirteen strong signatures of selection. Among these, four (surrounding the KITLG, KIT, EDN3 and ALB genes) contained SNPs strongly associated with the piebald coloration pattern while a fifth (surrounding PLAG1) could be associated to morphological differences across the populations. Finally, analysis of Pool–Seq data from 12 populations ofLittorina saxatilisliving in two different ecotypes illustrates how the proposed framework might help addressing relevant ecological issue in non–model species. Overall, the proposed methods define a robust Bayesian framework to characterize adaptive genetic differentiation across populations. The BayPassprogram implementing the different models is available athttp://www1.montpellier.inra.fr/CBGP/software/baypass/.
Comparing Variant Call Files for Performance Benchmarking of Next-Generation Sequencing Variant Calling Pipelines
Authors: Cleary John G. , Braithwaite Ross , Gaastra Kurt , Hilbush Brian S. , Inglis Stuart , Irvine Sean A. , Jackson Alan , Littin Richard , Rathod Mehul , Ware David , Zook Justin M. , Trigg Len , De La Vega Francisco M. 
Published: August 2015

ABSTRACTSummaryTo evaluate and compare the performance of variant calling methods and their confidence scores, comparisons between atest callset and a“gold standard”need to be carried out. Unfortunately, these comparisons are not straightforward with the current Variant Call Files (VCF), which are the standard output of most variant calling algorithms for high-throughput sequencing data. Comparisons of VCFs are often confounded by the different representations of indels, MNPs, and combinations thereof with SNVs in complex regions of the genome, resulting in misleading results. A variant caller is inherently a classification method designed to score putative variants with confidence scores that could permit controlling the rate of false positives (FP) or false negatives (FN) for a given application. Receiver operator curves (ROC) and the area under the ROC (AUC) are efficient metrics to evaluate a test call set versus a gold standard. However, in the case of VCF data this also requires a special accounting to deal with discrepant representations. We developed a novel algorithm for comparing variant call sets that deals with complex call representation discrepancies and through a dynamic programing method that minimizes false positives and negatives globally across the entire call sets for accurate performance evaluation of VCFs.AvailabilityRTG Tools is implemented as a multithreaded Java application and source code is available under BSD license at:https://github.com/RealTimeGenomics/rtg-toolsContactlen@realtimegenomics.comSupplementary informationSupplementary data are available atBioinformatics online.
Public responses to a comprehensive smoking ban
Authors: Greenwald Howard P. 
Published: August 2015

Purpose
– The purpose of this paper is to report public reactions to a total workplace smoking ban, including smoking behavior, attendance at bars and clubs, and attitudes toward a broader ban.

Design/methodology/approach
– Surveys were conducted in two adjacent jurisdictions, one of which instituted a total workplace smoking ban. Surveys took place before (n=1,609) and after (n=1,600) enactment of the ban in the relevant jurisdiction.

Findings
– No change in smoking prevalence occurred in the jurisdiction enacting the ban. Strong majorities of non-smokers supported the ban, while strong majorities of smokers expressed opposition. In the jurisdiction that enacted the ban, smokers who appeared to be high-volume consumers at bars and clubs were most likely to report reducing attendance at these establishments and to oppose the ban.

Research limitations/implications
– Surveys depend on accurate self-reporting of behavior and attitudes.

Practical implications
– Some bars and clubs may incur financial losses due to smoking bans. A core of strong opponents can undermine public consensus regarding smoking bans. Licensing a limited number of bars and clubs to allow smoking can safeguard this consensus.

Social implications
– Limited smoking bans can serve as a means of harm reduction, as non-smokers are protected from environmental tobacco smoke, and accommodation of smokers reduces their motivation to oppose bans.

Originality/value
– This investigation makes use of detailed data on the public’s thinking and reactions to a comprehensive smoking ban and is a before-after study with controls.
Survey of knowledge of legal highs (novel psychoactive substances) amongst London pharmacists
Authors: Guirguis Amira , Corkery John M. , Stair Jacqueline L. , Kirton Stewart , Zloh Mire , Goodair Christine M. , Schifano Fabrizio , Davidson Colin 
Published: August 2015

Purpose
– The purpose of this paper is to determine pharmacists’ knowledge of legal highs (novel psychoactive substances (NPS)).

Design/methodology/approach
– A questionnaire was handed out at two London pharmacist continuing education events in mid-2014. These events update pharmacists about developments of interest/relevance to the profession and to improve their practice. A total of 54 forms were returned; a response rate of 26 percent.

Findings
– Most pharmacists had poor knowledge of NPS and many considered that NPS were not important to their work, with few having had to advise customers in this area. Despite this, the majority thought that they had insufficient information about NPS. There was a negative correlation between the age of the pharmacist and knowledge of NPS.

Research limitations/implications
– The sample is a self-selected one drawn from registered pharmacists working in community pharmacies in northwest London, and thus does not include hospital pharmacies. Self-selection means that respondents may only reflect those who are interested in the NPS phenomenon and not the wider pharmacy community. The geographical area covered may not be representative of London as a whole, or indeed other parts of the UK or other EU countries.

Practical implications
– It is clear that pharmacists do not know much about NPS but would like to know more. This information might improve their practice.

Social implications
– Pharmacists, easier to see than general practitioners, could be a useful source of information for NPS misusers.

Originality/value
– There have been no previous attempts to gauge the level of knowledge by pharmacists of legal highs/NPS in the UK or elsewhere to our knowledge.
Applying central pattern generators to control the robofish with oscillating pectoral fins
Authors: Cao Yong , Bi Shusheng , Cai Yueri , Wang Yuliang 
Published: August 2015

Purpose– This paper aims to develop a robofish with oscillating pectoral fins, and control it to mimic the bionic prototype by central pattern generators (CPGs).Design/methodology/approach– First, the oscillation characteristics of the cownose ray were analyzed quantitatively. Second, a robofish with multi-joint pectoral fins was developed according to the bionic morphology and kinematics. Third, the improved phase oscillator was established, which contains a spatial asymmetric coefficient and a temporal asymmetric coefficient. Moreover, the CPG network is created to mimic the cownose ray and accomplish three-dimensional (3D) motions. Finally, the experiments were done to test the authors ' works.Findings– The results demonstrate that the CPGs is effective to control the robofish to imitate the cownose ray realistically. In addition, the robofish is able to accomplish 3D motions of high maneuverability, and change among different swimming modes quickly and smoothly.Originality/value– The research provides the method to develop a robofish from both 3D morphology and kinematics. The motion analysis and CPG control make sure that the robofish has the features of high maneuverability and camouflage. It is useful for military underwater applications and underwater detections in narrow environments. Second, this work lays the foundation for the autonomous 3D control. Moreover, the robotic fish can be taken as a scientific tool for the fluid bionics research.
Impact of ERP systems usage on organizational agility
Authors: Aburub Faisal 
Published: August 2015

Purpose– Enterprise resource planning (ERP) systems can be considered as cornerstone that allows most organizations to achieve their business goals. The purpose of this paper is to investigate the impact of ERP system usage on agility in organizations.Design/methodology/approach– The data were collected from 90 branches of well-known banks in the Middle East, such as HSBC, Standard Chartered and Arab Bank. Data were analyzed using a path analysis methodology.Findings– A new model has been developed. An empirical investigation was performed on the banking sector in the Middle East to test the new model. Despite the results showing that the impact of ERP system usage on banks’ agility is significant, the variance of banks’ agility that is explained by the use of ERP systems is weak. This indicates that ERP usage may not influence sufficiently the current agility drivers in Middle-Eastern banks and that there may be other significant variables that contribute to agility in the banking sector.Research limitations/implications– The findings of this research were based on a survey conducted among banks in the Middle East. The results are applicable in Middle-Eastern banks, but may not be applicable in other regions.Practical implications– Banking practitioners in the Middle East should be aware that successful implementation of ERP systems may not lead to the achievement of sufficient competency, flexibility, quickness, and responsiveness. Hence, such implementation may not deliver banking agility.Originality/value– This research model investigates the impact of ERP usage on the agility of banks in the Middle East.
Sending mobile messages to different social ties in modern urban life
Authors: Cho Vincent , Hung Humphry 
Published: August 2015

Purpose– The purpose of this paper is to investigate the effectiveness of mobile messaging for the purposes of information sharing and social networking based on the types of social ties involved. The authors identify two psychological traits in the model: perceived time shortages (TSs) and anxiety trait. These traits can influence individuals’ mobile-messaging usage by facilitating users’ connections to different social ties in modern urban life.Design/methodology/approach– The authors distributed questionnaires at random on the streets of certain densely populated areas in Hong Kong to young urbanites, who are the dominant users of technological social media. The authors collected 492 valid responses, which the authors analysed via multivariate regression analysis.Findings– Mobile messages are more effectively used to share information within strongly tied groups rather than weakly tied groups. However, there is little difference between weakly and strongly connected groups in terms of the perceived effectiveness of mobile messages used for social networking. Anxious people are more inclined to send mobile messages to individuals with whom they have weak ties, and people who perceived TSs send more mobile messages to individuals with whom they have strong ties.Research limitations/implications– The rapid nature of information and communication technology has enabled new “richer” forms of mobile media. For instance, WhatsApp allows people to attach images and other multimedia files to their messages, and WeChat provides a location-sharing service that enables users to meet new people based on their friendship preferences. Future studies should examine this trend.Originality/value– This study contributes to the literature by elaborating the mobile-messaging behaviour of urban citizens who are anxious and perceive TSs within strongly and weakly connected social groups.
Knowledge management implementation, business process, and market relationship outcomes
Authors: Hung Shin-Yuan , Tsai Jacob Chia-An , Lee Wen-Ting , Chau Patrick Y.K. 
Published: August 2015

Purpose
– Prior studies examine the relationship between knowledge management (KM) enablers and KM effectiveness. However, the critical role of business process outcome is neglected. The purpose of this paper is to understand the mediating effect of business process outcomes. Based on knowledge-based view (KBV), two KM enabler variables, KM infrastructure (KMI) and KM capabilities (KMC), and one KM effectiveness variable, market relationships, are included.

Design/methodology/approach
– A survey was conducted. The sampling frame was obtained from the database of the Bureau of National Health Insurance and Financial Supervisory Commission in Taiwan. After unusable questionnaires excluded, the usable respondents were 256 which are from 63 hospitals and 93 financial firms. Structural equation modeling was used to analyze the relationships among KMI, KMC, business process outcome, and market relationships.

Findings
– The findings indicated that both KMI and KMC have positive influences on market relationships through business process outcome. The authors also demonstrate how KMI and KMC improve market relationships through business process outcome to deliver the value of KM.

Originality/value
– Based on KBV, KMI and KMC are as KM enablers to facilitate KM activities. In the light of professional service industries (i.e. hospitals and financial firms), the study highlights the mediating effect of business process outcomes between KM enablers and KM effectiveness. It furthers the understanding of how KM enablers can improve KM effectiveness.
Marketing sustainability in the luxury lodging industry: a thematic analysis of preferences amongst the Indian transition generation
Authors: Rishi Meghna , Jauhari Vinnie , Joshi Gaurav 
Published: August 2015

Purpose– This paper aims to identify emerging themes that can help in understanding the preferences of Indian consumers, in the transition generation (25-44 years) (Sinha, 2011), toward sustainability in the luxury lodging industry.Design/methodology/approach– The paper uses a multi-method approach for data collection. Thorough literature review and personal interviews with marketers were conducted to explore the themes and construct tentative thematic webs. In total, 42 customer inputs were drawn through focus groups and personal interviews to validate the themes. Customer perspective, marketers’ perspective and findings from literature were juxtaposed to understand the themes.Findings– “Influence of Parents, Children and Travel agents”, “Rewards for green behaviour” and “frequent communication around sustainability efforts” have been identified as some of the key motivations for consumers to choose sustainability. Some deterrents have been identified as “limited awareness about sustainability issues in Tier II cities”, “detachment with the hotel’s operations”, “higher prices” and “unchecked wasteful/acquisitive consumption”.Practical implications– Findings from this research work have implications for the practitioners and policy-makers because establishing an understanding of the factors that deter and motivate consumers for engaging in green behavior is important for designing meaningful marketing strategies.Originality/value– Findings are based on the analysis of data from customer inputs and industry inputs. Themes in this research work have been analytically identified, and this study has made significant academic contributions to the marketing literature. It also provides valuable insights for the practitioners.
Issuers’ credit risk and pricing of warrants in the recent financial crisis
Authors: Schertler Andrea , Stoerch Saskia 
Published: August 2015

Purpose
– The purpose of this paper is to investigate whether factor sensitivities of margins of bank-issued warrants depend on issuers’ credit risk during the period of economic turmoil between January 2008 and June 2010.

Design/methodology/approach
– Therefore, first, Fama–MacBeth estimations were applied and it was demonstrate that the sensitivities of margins in terms of time to maturity and moneyness vary substantially over time; the average outcomes are similar to the results of classical pooled estimations.

Findings
– Then, time-series tests were used and it was found that the steepness of the issuers’ credit default swap (CDS) spread curves correlates negatively with the time-to-maturity sensitivities as well as with the explanatory power of Fama–MacBeth estimations.

Research limitations/implications
– These findings indicate that the life-cycle hypothesis is weakened when the issuers’ CDS spread curves become steeper.

Originality/value
– Thus, this study offers a new approach to gain insights into the role of issuers’ credit risk on price setting behavior.