bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tamibarotene As Maintenance Therapy for Acute Promyelocytic Leukemia: Results From a Randomized Controlled Trial
Authors: Shinagawa Katsuji , Yanada Masamitsu , Sakura Toru , Ueda Yasunori , Sawa Masashi , Miyatake Junichi , Dobashi Nobuaki , Kojima Minoru , Hatta Yoshihiro , Emi Nobuhiko , Tamaki Shigehisa , Gomyo Hiroshi , Yamazaki Etsuko , Fujimaki Katsumichi , Asou Norio , Matsuo Keitaro , Ohtake Shigeki , Miyazaki Yasushi , Ohnishi Kazunori , Kobayashi Yukio , Naoe Tomoki 
Published: September 2014

Purpose The introduction of all-trans-retinoic acid (ATRA) has significantly improved outcomes for acute promyelocytic leukemia (APL), although a subset of patients still suffer relapse. The purpose of this study was to evaluate the role of maintenance therapy with the synthetic retinoid tamibarotene in APL. Patients and Methods Patients with newly diagnosed APL in molecular remission at the end of consolidation therapy were randomly assigned to receive ATRA or tamibarotene, both orally, for 14 days every 3 months for up to 2 years. Results A total of 347 patients were enrolled. Of the 344 eligible patients, 319 (93%) achieved complete remission. After completing three courses of consolidation therapy, 269 patients underwent maintenance random assignment. The relapse-free survival (RFS) rate at 4 years was 84% for the ATRA arm and 91% for the tamibarotene arm (hazard ratio [HR], 0.54; 95% CI, 0.26 to 1.13). When the analysis was restricted to 52 high-risk patients with an initial WBC count ≥ 10.0 × 109/L, the intergroup difference was statistically significant, with 4-year RFS rates of 58% for the ATRA arm and 87% for the tamibarotene arm (HR, 0.26; 95% CI, 0.07 to 0.95). For patients with non–high-risk disease, the HR was 0.82 (95% CI, 0.32 to 2.01). The test for interaction between treatment effects and these subgroups resulted in P = .075. Both treatments were generally well tolerated. Conclusion In this trial, no difference was detected between ATRA and tamibarotene for maintenance therapy. In an exploratory analysis, there was a suggestion of improved efficacy of tamibarotene in high-risk patients, but this requires further study.
Twin-Spirited Woman
Authors: Wesley Saylesh 
Published: September 2014

AbstractCoast Salish people, particularly the Stó:lõ of the lower Fraser Valley, have lost much of their language, histories, and teachings as a result of colonization. One such important identity that has been forgotten or erased is the two-spirited role. The author wishes to revitalize the cultural roles of transgendered/two-spirit people within the Coast Salish territory and ways in which they historically contributed to their societies prior to colonization. Traditionally, the Stó:lõ are matriarchal and matrilineal, and only grandmothers can create any new laws for their descendants. Thus given the vital role played by the author's grandmother in her process, this essay is a long-overdue proposal to all living grandmothers not only to stand by and accept their two-spirited grandchildren but to call for a celebration of their coming out. This visionary work serves to inspire future generations of Stó:lõ to fully embrace all members of their community, especially two-spirits. The first Sts'iyóye Smestíyexw Slhá:li, or Twin-Spirited Woman, as this essay is about, offers an example to this sacred work.
For a Queer Pedagogy of Friendship
Authors: Cornejo Giancarlo 
Published: September 2014

Abstract
This hybrid essay/narrative attempts to give an account of the survival of a “queer” subject, specifically a trans child living in Lima, Peru, in the 1950s and 1960s. My theoretical claims may be simple, but the survival of this trans child was anything but simple. The essay argues that in the survival of this child, friendship played a vital role.
Toms and Zees
Authors: Ravine Jai Arun 
Published: September 2014

Abstract
Who is Zee? Zee is a site of dissonance that helps illustrate how Thai and Western concepts of gender and queerness converge and collide. How Zee is frequently recognized as male but then constantly reiterated as female while embodying a certain gender ambiguity in language and appearance is a product of the slippage between geographically and culturally specific understandings of gender, which unfortunately causes Thai FTMs in both the United States and Thailand to experience isolation and alienation from Thai community, a silence camouflaged by that very ambiguity.
Molybdenum Source for Increase of Molybdenum Content in Electrodeposited Cu–Mo Composites
Authors: Gotou Miku , Arakawa Tomiyuki , Watanabe Nobuaki , Hara Takatoshi , Tomita Tatsuya , Hashimoto Akira , Takanashi Hiroshi , Koiwa Ichiro 
Published: September 2014

Abstract
Cu–Mo composites have been expected to be materials of heat sinks in electron devices. We have formed Cu–Mo composites by electrodeposition. Molybdenum content in Cu–Mo composites formed by using Na2MoO4 was larger than that in ones formed by using H3(PMo12O40). Molybdenum content, over 30 wt % in Cu–Mo composites was obtained.
Digital Content Provision and Optimal Copyright Protection
Authors: Guo Liang , Meng Xiangyi 
Published: September 2014

Advances in digital technologies have led to an increasing concern about piracy for providers of digital content (e.g., e-books, games, music, software, videos). Yet controversies exist over the influence of copyright protection on firm profitability. The objective of this paper is to provide an alternative rationale for the growing anti-protection trend and to investigate optimal copyright enforcement and quality provision in a monopoly setting. The proposed economic mechanism centers on the influence of copyright protection on consumer search when consumers can get to know the firm’s actions (e.g., price, quality) only after costly search. We show that more stringent copyright protection can induce the consumers to rationally expect lower ex post surplus, thus exerting a negative strategic effect on the consumers' willingness to search. This strategic effect may outweigh the positive main effect on the relative attractiveness of the authorized versus the pirated product, which can hence explain the optimality of incomplete and even zero copyright protection policies in markets where consumer prepurchase search is important (e.g., information goods, digital products). It is also because of this strategic effect that the firm may provide lower quality as copyright enforcement increases. Interestingly, quality unobservability can moderate this strategic effect and thus lead to an increasing incentive for copyright protection. This paper was accepted by Pradeep Chintagunta, marketing.
Observation-centered Approach to ASD Assessment in Tanzania
Authors: Harrison Ashley J. , Zimak Eric H. , Sheinkopf Stephen J. , Manji Karim P. , Morrow Eric M. 
Published: September 2014

Abstract
In many lower-income countries, there is a paucity of assessment services for autism spectrum disorders (ASD)., Guidelines will be provided for conducting cross-cultural assessments in the context of limited validated resources in Tanzania. By examining behavioral, social, and adaptive differences we were able to provide differential diagnostic evaluations aligning with best practice standards for 41 children in Tanzania age 2–21 years. We describe the utility of a flexible, behavioral observation instrument, the Childhood Autism Rating Scales, Second Edition (CARS2), to gather diagnostic information in a culturally sensitive manner. We observed that the ASD group was characterized by significantly higher scores on the CARS2, F  =  21.09, p &lt; .001, η2  =  .37, than the general delay comparison group. Additional recommendations are provided for making cultural adaptations to current assessment instruments for use in a country without normed instruments, such as Tanzania.
Dimensions of Temporality in President Obama’s Tucson Memorial Address
Authors: Amsden Brian 
Published: September 2014

Abstract
President Obama’s speech following the January 2011 mass shooting in Tucson, Arizona employed a series of temporal shifts to help the nation integrate the tragedy into its collective consciousness. This essay identifies four dimensions of temporality that were developed in the Tucson Memorial Address and analyzes their interrelationships. It argues that rhetoric can better facilitate judgment by providing auditors with multiple interrelated but individually untotalizable temporal perspectives. By that standard, the Tucson Address employs a temporal network that serves as a significant impediment to rhetorical judgment.
Manners of human gait: a crosslinguistic event-naming study
Authors: Slobin Dan I. , Ibarretxe-Antuñano Iraide , Kopecka Anetta , Majid Asifa 
Published: September 2014

AbstractCrosslinguistic studies of expressions of motion events have found that Talmy's binary typology of verb-framed and satellite-framed languages is reflected in language use. In particular, Manner of motion is relatively more elaborated in satellite-framed languages (e.g., in narrative, picture description, conversation, translation). The present research builds on previous controlled studies of the domain of human motion by eliciting descriptions of a wide range of manners of walking and running filmed in natural circumstances. Descriptions were elicited from speakers of two satellite-framed languages (English, Polish) and three verb-framed languages (French, Spanish, Basque). The sampling of events in this study resulted in four major semantic clusters for these five languages: walking, running, non-canonical gaits (divided into bounce-and-recoil and syncopated movements), and quadrupedal movement (crawling). Counts of verb types found a broad tendency for satellite-framed languages to show greater lexical diversity, along with substantial within group variation. Going beyond most earlier studies, we also examined extended descriptions of manner of movement, isolating types of manner. The following categories of manner were identified and compared: attitude of actor, rate, effort, posture, and motor patterns of legs and feet. Satellite-framed speakers tended to elaborate expressive manner verbs, whereas verb-framed speakers used modification to add manner to neutral motion verbs.
Structure, mechanism and application of vinyl alcohol oligomers grafted onto poly(3-hydroxybutyrate): a proposal
Authors: Torres Maykel González , Pérez Manuel González , Cervantes Eric Reyes , Cerna Cortez Jorge Raúl , Muñoz Susana Vargas , Rodríguez Talavera José Rogelio 
Published: September 2014

AbstractOligomers of poly(vinyl alcohol) were grafted onto poly(3-hydroxybutyrate) (PHB) by radiation-induced polymerization. The aim of this study was to elucidate the structure of these copolymers using nuclear magnetic resonance (heteronuclear multiple quantum coherence) spectroscopy supported by dynamic light scattering (DLS) and atomic force microscopy (AFM). It was concluded that vinyl alcohol (VA) was grafted onto PHB for the methylenic and methynic sites. A mechanism for the grafting reaction was proposed based on the experimental evidence. AFM and DLS allowed the characterization of the particles obtained from P(HB-g-VA). The prepared materials showed suitable properties for use in drug delivery systems.
Comparison of Physicochemical and Gel Characteristics of Hydroxypropylated Oat and Wheat Starches
Authors: Majzoobi Mahsa , Saberi Bahareh , Farahnaky Asgar , Mesbahi Gholamreza 
Published: September 2014

Abstract
The main objective of this study was to compare the characteristics of hydroxypropylated (HP) wheat and oat starches. Higher degree of modification was obtained for HP wheat starch. Hydroxypropylation did not change the morphological features of HP oat starch granules, while it had some effects on the granular structure of HP wheat starch. The relative crystallinity of HP oat starch was higher than that of HP wheat starch. The water swelling and solubility of the HP wheat starch were higher than the HP oat starch. In contrast to HP wheat starch, the HP oat starch gel showed improved textural properties. After hydroxypropylation, peak and breakdown viscosity increased while set back viscosity and peak time decreased. Higher onset, peak and conclusion temperatures, and higher enthalpy of gelatinization were obtained for the HP oat starch. HP wheat starch gel had less syneresis than the HP oat starch.
MHD Stagnation Point Flow of Second Grade Fluid over a Stretching Cylinder with Heat and Mass Transfer
Authors: Hayat T. , Anwar M. S. , Farooq M. , Alsaedi A. 
Published: September 2014

Abstract
This paper presents magnetohydrodynamic (MHD) stagnation point flow of second grade fluid over a permeable stretching cylinder. Analysis has been carried out with heat and mass transfer. Viscous dissipation and Joule heating effects are also investigated. Suitable transformations are used to convert non-linear partial differential equations into the non-linear ordinary differential equations. Variation of different parameters on the velocity, temperature and concentration profiles are shown graphically. Numerical values of skin friction coefficient, Nusselt number and Sherwood number are computed. Comparison of f″(0), −θ′(0) and −c′(0) with the previous results are also examined.
Linear Solutions for Irregularly Decimated Generators of Cryptographic Sequences
Authors: Fúster-Sabater A. 
Published: September 2014

Abstract
In the present work, it is shown that the sequences obtained from a cryptographic sequence generator, the so-called shrinking generator, are just particular solutions of a type of linear difference equations. Moreover, all these sequences are simple linear combinations of m-sequences weighted by other sequences that correspond to the diagonals of the Sierpinski's triangle. These facts suggest a subtle link between irregular decimation and linearity that can be conveniently exploited in the analysis of cryptographic sequences. Previous ideas can be easily extended to other decimation-based cryptographic generators as well as to interleaved sequence generators.
Can we use seasonally adjusted variables in dynamic factor models?
Authors: Camacho Maximo , Lovcha Yuliya , Quiros Gabriel Perez 
Published: September 2014

Abstract
We examine the short-term performance of two alternative approaches of forecasting from dynamic factor models. The first approach extracts the seasonal component of the individual variables before estimating the model, while the alternative uses the non seasonally adjusted data in a model that endogenously accounts for seasonal adjustment. Our Monte Carlo analysis reveals that the performance of the former is always comparable to or even better than that of the latter in all the simulated scenarios. Our results have important implications for the factor models literature because they show the that the common practice of using seasonally adjusted data in this type of models is very accurate in terms of forecasting ability. Using five coincident indicators, we illustrate this result for US data.
Synchronous GH- and prolactin-secreting pituitary adenomas
Authors: Rahman Maryam , Jusué-Torres Ignacio , Alkabbani Abdulrahman , Salvatori Roberto , Rodríguez Fausto J , Quinones-Hinojosa Alfredo 
Published: September 2014

Summary
Pituitary adenomas are usually solitary lesions. Rarely, patients may present with two distinct pituitary tumors. We report a case of synchronous secretory pituitary adenomas in a woman who initially presented with elevated prolactin levels. She was initially treated with cabergoline, but, after many years, she began developing symptoms consistent with acromegaly. Imaging revealed two distinct tumors within the pituitary gland. Endocrinological investigation confirmed acromegaly. At the time of surgery, two separate tumors were identified and resected. Pathological analysis demonstrated one tumor as a prolactinoma, and the other tumor as a GH-secreting adenoma. Postoperatively, her GH and IGF1 levels normalized, while the prolactin level remained slightly above normal. This case highlights that GH and prolactin level elevation is not always from co-secretion by the same adenoma.

Learning points

Synchronous pituitary adenomas represent <0.5% of pituitary tumors requiring surgery.

In the setting of elevated GH and prolactin levels, one cannot assume that they are co-secreted by the same adenoma.

A careful study of hormonal workup and pre-operative imaging is necessary for synchronous pituitary adenomas to assure resection of both tumors.
The use of cinacalcet in pregnancy to treat a complex case of parathyroid carcinoma
Authors: Nadarasa K , Bailey M , Chahal H , Raja O , Bhat R , Gayle C , Grossman A B , Druce M R 
Published: September 2014

Summary
We present the case of a patient with metastatic parathyroid carcinoma whose hypercalcaemia was medically managed through two pregnancies. The diagnosis was made when the patient presented with chronic knee pain and radiological findings consistent with a brown tumour, at the age of 30. Her corrected calcium and parathyroid hormone (PTH) levels were significantly elevated. Following localisation studies, a right parathyroidectomy was performed with histology revealing parathyroid carcinoma, adherent to thyroid tissue. Aged 33, following biochemical recurrence of disease, the patient underwent a second operation. A subsequent CT and FDG–PET revealed bibasal pulmonary metastases. Aged 35, the patient was referred to our unit for treatment of persistent hypercalcaemia. The focus of treatment at this time was debulking metastatic disease using radiofrequency ablation. Despite advice to the contrary, the patient conceived twice while taking cinacalcet. Even though there are limited available data regarding the use of cinacalcet in pregnancy, both pregnancies continued to term with the delivery of healthy infants, using intensive medical management for persistent hypercalcaemia.

Learning points

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism.

Hypercalcaemia during pregnancy can result in significant complications for both the mother and the foetus.

The use of high-dose cinacalcet in pregnancy has been shown, in this case, to aid in the management of resistant hypercalcaemia without teratogenicity.
Population- and Sex-Biased Gene Expression in the Excretion Organs ofDrosophila melanogaster
Authors: Huylmans Ann Kathrin , Parsch John 
Published: September 2014

AbstractWithin species, levels of gene expression typically vary greatly between tissues, sexes, individuals, and populations. To investigate gene expression variation between sexes and populations in a single somatic tissue, we performed a quantitative analysis of the Malpighian tubule transcriptome in adult males and females of Drosophila melanogaster derived from two distinct populations (one from sub-Saharan Africa and one from northern Europe). We identified 2308 genes that differed in expression between the sexes and 2474 genes that differed in expression between populations at a false discovery rate of 5%. We also identified more than 1000 genes that showed a sex-by-population interaction in their expression. The genes that differed in expression between sexes showed enrichment for a wide variety of functions, although only 55% of them overlapped with sex-biased genes identified in whole-fly studies. The genes expressed differentially between populations included several that were previously implicated in adaptive regulatory evolution, an excess of cytochrome P450 genes, and many genes that were not detected in previous studies of whole flies. Our results demonstrate that there is abundant intraspecific gene expression variation within in a single, somatic tissue and uncover new candidates for adaptive regulatory evolution between populations.
The Genetic Architecture of Seed Composition in Soybean Is Refined by Genome-Wide Association Scans Across Multiple Populations
Authors: Vaughn Justin N , Nelson Randall L , Song Qijian , Cregan Perry B , Li Zenglu 
Published: September 2014

Abstract
Soybean oil and meal are major contributors to world-wide food production. Consequently, the genetic basis for soybean seed composition has been intensely studied using family-based mapping. Population-based mapping approaches, in the form of genome-wide association (GWA) scans, have been able to resolve loci controlling moderately complex quantitative traits (QTL) in numerous crop species. Yet, it is still unclear how soybean’s unique population history will affect GWA scans. Using one of the populations in this study, we simulated phenotypes resulting from a range of genetic architectures. We found that with a heritability of 0.5, ∼100% and ∼33% of the 4 and 20 simulated QTL can be recovered, respectively, with a false-positive rate of less than ∼6×10−5 per marker tested. Additionally, we demonstrated that combining information from multi-locus mixed models and compressed linear-mixed models improves QTL identification and interpretation. We applied these insights to exploring seed composition in soybean, refining the linkage group I (chromosome 20) protein QTL and identifying additional oil QTL that may allow some decoupling of highly correlated oil and protein phenotypes. Because the value of protein meal is closely related to its essential amino acid profile, we attempted to identify QTL underlying methionine, threonine, cysteine, and lysine content. Multiple QTL were found that have not been observed in family-based mapping studies, and each trait exhibited associations across multiple populations. Chromosomes 1 and 8 contain strong candidate alleles for essential amino acid increases. Overall, we present these and additional data that will be useful in determining breeding strategies for the continued improvement of soybean’s nutrient portfolio.
Single-Family Room Care and Neurobehavioral and Medical Outcomes in Preterm Infants
Authors: Lester Barry M. , Hawes Katheleen , Abar Beau , Sullivan Mary , Miller Robin , Bigsby Rosemarie , Laptook Abbot , Salisbury Amy , Taub Marybeth , Lagasse Linda L. , Padbury James F. 
Published: September 2014

OBJECTIVE:To determine whether a single-family room (SFR) NICU, including factors associated with the change to a SFR NICU, is associated with improved medical and neurobehavioral outcomes.METHODS:Longitudinal, prospective, quasi-experimental cohort study conducted between 2008 and 2012 comparing medical and neurobehavioral outcomes at discharge in infants born &lt;1500 g. Participants included 151 infants in an open-bay NICU and 252 infants after transition to a SFR NICU. Structural equation modeling was used to determine the role of mediators of relations between type of NICU and medical and neurobehavioral outcomes.RESULTS:Statistically significant results (all Ps ≤.05) showed that infants in the SFR NICU weighed more at discharge, had a greater rate of weight gain, required fewer medical procedures, had a lower gestational age at full enteral feed and less sepsis, showed better attention, less physiologic stress, less hypertonicity, less lethargy, and less pain. NICU differences in weight at discharge, and rate of weight gain were mediated by increased developmental support; differences in number of medical procedures were mediated by increased maternal involvement. NICU differences in attention were mediated by increased developmental support. Differences in stress and pain were mediated by maternal involvement. Nurses reported a more positive work environment and attitudes in the SFR NICU.CONCLUSIONS:The SFR is associated with improved neurobehavioral and medical outcomes. These improvements are related to increased developmental support and maternal involvement.