bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mineralogy of Lateritic Weathering Profiles Developed on the Rocks under a Sub-equatorial Monsoon Climate: Case of the Bambouto Mountains
Authors: Bertille Ilalie Manefouet Kentsa , Véronique Kamgang Kabeyene , Armand Wouatong , Katte Valentine 
Published: July 2024

ABSTRACT
The main objective of this work is to make a comparative assessment of the mineralogy on weathering profiles resulting from the alteration of the different rocks in an equatorial microclimate of altitude. This was carried out in the lower flank of the southern slope of the Bambouto Mountains. Mineralogical analysis and normative restructuring have given very interesting results on the profiles, between the basement rocks and the surface/cover rocks. Given that the alteration pathways of the basement rocks are different, they are similar within the zone of containment and potential leaching. Meanwhile, the cover rocks vary from one domain to another: virtual weathering, potential confinement, potential and virtual weathering, and induration. The alterological activity is very intense in the profile on trachybasalt. The predominant weathering processes in all cases are allitization and monosialitization, which are marked by a singular phenomenon of ferrolysis. The characteristic minerals of this profile are kaolinite and diopside. The weathering profile on biotite and hornblende granitoid is not very differentiated and is particularly rich in quartz (max: 40 weight-%) and microcline (max: 40 weight-%). The soils developed on granitoid, adopt elastic-fragile deformation to elastoplastics with sharp break in relation to the load applied. The alteration profile on orthogneiss is poorly differentiated, and thin, with a low degree of alteration. Hydrolytic alteration by monosiallitization marked this profile. This is particularly rich in quartz (max: 100 weight-%) and kaolinite (max: 57 weight-%). The profile on anatexite is particularly rich in quartz (max: 66 weight-%) and kaolinite (max: 40 weight-%). The normative restructuring confirmed over 98 weight-% of the various minerals obtained and thus made it possible to better characterize the alteration and its application in geotechnics. These soils constitute potential deposits of chromatogenic minerals: kaolinite, hematite, goethite, gibbsite, magnetite, biotite.
Molecular classifications of gastric cancer and their clinical potential
Authors: Nemtsova M. V. , Molchanov A. D. , Kuznetsova E. B. , Bure I. V. 
Published: July 2024

Gastric cancer if the 5th most common oncological disease in the world and one of the leading causes of death associated with this pathology. In clinical practice, the Lauren classification is widely used for gastric cancer characterization, but it does not provide accurate information on tumor progression and does not allow to select the optimal therapeutic approach. More modern tumor typologies, for example proposed by the The Cancer Genome Atlas (TCGA) and the Asian Cancer Research Group (ACRG), are based on profiling of molecular changes in the tumor genome. Currently, several new classifications exist dividing gastric cancer into groups depending on response to different treatment, for example, checkpoint inhibitors or therapy based on activity of pathological pathways associated with immunity, DNA repair, oncogenic and stromal signatures. The proposed typologies improve diagnosis and treatment of this pathology. The review describes currently available classifications of gastric tumors and considers their practical potential.
Potential to use of viral reverse transcriptase inhibitors in oncology
Authors: Vlasova O. A. , Antonova I. A. , Magomedova Kh. M. , Usolkina M. A. , Kirsanov K. I. , Belitsky G. A. , Valiev T. T. , Yakubovskaya M. G. 
Published: July 2024

In preparing the review, articles on the functioning of the reverse transcriptase enzyme of endogenous repeat sequences LINE1, the mechanisms of action and antitumor activity of viral reverse transcriptase inhibitors. Articles available in the biomedical literature information databases SciVerse Scopus, PubMed, Web of Science, Russian Science CitationIndex (RSCI) were analyzed. The review used information from 140 publications, of which 95 and 39 were published, respectively, over the last ten and three years, 2 articles present the results of clinical studies, and 45 articles refer to results demonstrating the anticancer properties of the studied compounds in various models in vitro and in vivo. Aim. Based on data on the functional properties of the reverse transcriptase enzyme of endogenous repeat sequences LINE1 (long interspersed nuclear elements 1), analyze the potential use of viral reverse transcriptase inhibitors in oncology, presenting their classification and main mechanisms of action. About 98 % of the human genome consists of repetitive sequences, most of which are represented by mobil genetic elements, the activation of which leads to increased genome instability. These include long (LINE) and short (SINE) interspersed nuclear element repeated DNA sequences interspersed nuclear elements, respectively, which occupy about 45 % of the human genome. Increased expression levels of these sequences in the genome have been identified in many forms of malignant neoplasms. Their transposition occurs due to the expression of LINE1-encoded reverse transcriptase, whichis homologous to viral reverse transcriptase. To date, reverse transcriptase inhibitors of viruses of nucleoside and non-nucleoside structure have been developed and are successfully used in the clinic. These drugs demonstrate an inhibitory effect on both LINE1 reverse transcriptase and telomerase, which provides the tumor cell with the ability to overcome replicative senescence. Due to these properties, these compounds are expected to exhibit both their own antitumor activity and increase the sensitivity of tumor cells to the therapy of malignant neoplasms, which is experimentally confirmed in models of malignant tumors in vitro and in vivo. Use of reverse transcriptase inhibitors in combination therapy seems advisable both to prevent further genome rearrangements caused by LINE1 and to suppress the survival of tumor cells by inhibiting telomerase activity.
Mix-­and­-match Implantation of Multifocal and Extended Depth of Focus IOLs
Authors: Pershin K. B. , Pashinova N. F. , Tsygankov А. Yu. , Antonov E. A. , Kosova I. V. , Batalina L. V. 
Published: July 2024

Purpose: Analysis of results of combined implantation of non­diffractive IOL with extended depth of focus and multifocal IOL.Materials and methods. The study included 40 patients (80 eyes) after cataract phacoemulsification or clear lens removal with a mean follow­up of 15.4 ± 1.2 (12–22) months. Women accounted for 60 % (n = 24) and men for 40 % (n = 16). 20 patients (40 eyes) with bilateral AcrySof IQ Vivity implantation formed the minimonovision group (group I), and 20 patients (40 eyes) with AcrySof IQ Vivity implantation in the dominant eye (n = 20) and Acrysof IQ Panoptix implantation in the non­dominant eye (n = 20) formed the group of mix­-and­-match implantation (group II).Results. At the maximum follow­up period of 3 months, UCNVA in group I was 0.61 ± 0.14, in group II — 0.82 ± 0.09 (p = 0.048), BCNVA — 0.66 ± 0.17 and 0.92 ± 0.14, respectively (p = 0.039). No significant differences were found between groups comparing UCIVA, BCIVA, UCDVA and BCDVA (p > 0.1), but slightly higher values were determined in patients after bilateral implantation of Acrysof IQ Vivity IOLs. In group I, 2 patients (10 %) had glare and 2 (10 %) had halo. Patients did not complain about difficulties in driving in the darkness. In 9 cases out of 20 (45 %) patients required spectacle correction for reading. In group II, adverse optical phenomena were identified in 7 patients (35 %), of which 4 patients (20 %) had glare and 3 (15 %) had halo. None of the patients required spectacle correction for reading. In both groups, 95 % of cases (19 patients) rated the surgical outcome as “excellent” and 5 % (1 patient) as “good”. Conclusion. For the first time in Russia, the results of combined (mix­-and­match) implantation of EDOF and trifocal IOLs in comparison with bilateral IOL implantation in presbyopic patients were analyzed. The advantage of combined implantation for achieving better near visual acuity and comparable incidence of adverse optical phenomena was shown.
Volume and Structure of the Population’s Need for High-Tech Ophthalmological Care in Azerbaijan
Authors: Gadzhieva B. Kh. 
Published: July 2024

Purpose. Determine the volume and structure of high­tech ophthalmological care in Azerbaijan.Materials and methods. Materials from medical histories of patients hospitalized at the National Center of Ophthalmology named after Academician Z. Aliyeva (12 882 cases) for 2019 (from January 1 to December 31) were used. The need of hospitalized patients for high­tech ophthalmological care was determined in accordance with the list of types of high­tech medical care. The volume of demand of the population of Azerbaijan for GPs by type of indications and interventions was established per 100 thousand population with the determination of the average error of the indicator.Results. 14.5 ± 0.3 % of ophthalmological patients received high­tech ophthalmological care. The main types of high­tech ophthalmological care necessary to meet the needs of the population are transpupillary, microinvasive energetic optical­reconstructive and endovitreal 23.25 gage surgery for vitreoretinal pathologies of various origins (75.3 % of all types of operations; 16.63 ± 0.44 operations per 100 thousand population). The second place in the structure is occupied by complex surgical treatment of glaucoma, including microinvasive energy optical­reconstructive and laser surgery with possible implantation of silicone valve or metal drainage (11.3 % of all operations; 2.48 ± 0.17 operations per 100 thousand population).Conclusions. In Azerbaijan, the leading reasons for providing high­tech ophthalmological care are: cataracts complicated by lens luxation, glaucoma, pathology of the vitreous body, retina and choroid (27.0 % of all reasons; 5.96 ± 0.26 cases per 100 thousand population); retinal detachment and tears, tractional retinal detachment, other forms of retinal detachment in adults and children, complicated by pathology of the cornea, lens, vitreous body (22.1 % of all cases, 4.89 ± 0.24 cases per 100 thousand population). The most common type of hightech ophthalmological care is transpupillary, microinvasive energetic optical­reconstructive and endovitreal surgery for vitreoretinal pathologies of various origins (75.3 % of all types; 16.63 ± 0.44 cases per 100 thousand population).
Optimization of older adults’ home spaces to enhance their physical activity level and minimize sedentary behaviour: A qualitative study
Authors: Meghani Naureen Akber Ali , Hudson Joanne , Stratton Gareth , Mullin Jane 
Published: July 2024

There is a lack of studies focused explicitly on the impact of the home environment on older adults’ sedentary behaviour (SB) and physical activity (PA). The present study aims to investigate older adults’ perception of their home environment and its impact on their PA and SB. A qualitative exploratory research design was employed to conduct 33 in-depth interviews (IDIs) and five focus group (FGs; n=16) with older adults (mean age 71.7 ± 5.2 years). Using reflexive thematic analysis as an inductive coding approach, four themes were generated from the data set and were interpreted using the socio-ecological model (SEM): (I) Home layout and PA, (II) Space designation within the home, (III) Electronic equipment, furniture and material within the home space, (IV) Changing infrastructure within the home space. The findings highlight the significance of person-environment interaction at different layers of the SEM. Older adults have a significant influence on the physical environment of the home and how it is organized in terms of allocating space and equipment. However, utilization of space, and its intentional use (for active or sedentary behaviour) is also crucial, emphasizing individuals’ autonomy, freedom and control within the home environment. Moreover, both interpersonal and intrapersonal factors act as facilitators or barriers regarding necessary modifications within the home space to promote a conducive environment for PA. The current findings provide insight into the interaction of personal, social, community, and physical environment factors to these older adults’ PA and SB in their homes. Moreover, motivating older adults to develop more intention to have positive control over their environment is important. Further, promoting the notion of ‘think small for large effects’ within the home space will enable older adults to map out small-scale activities (such as avoiding screens in the bedroom or moving PA equipment to a convenient place) instead of making large-scale, less realistic infrastructure changes.
Karakteristik Tahu Sutra dengan Edible Coating Kitosan Selama Penyipanan
Authors: Ula Dina Hanifatul , Rusdianto Andrew Setiawan , Amilia Winda 
Published: July 2024

Tahu sutra merupakan makanan berbahan dasar kacang kedelai yang banyak dikonsumsi masyarakat Indonesia. Namun tahu sutra merupakan bahan pangan yang high perishable atau cepat rusak, hal ini menyebabkan tahu sutra tidak dapat bertahan lama. Tindakan pengawetan pada tahu sutra diperlukan agar umur simpan dan tingkat ketahanan tahu sutra menjadi lebih lama. Salah satu cara pengawetan alami tahu sutra menggunakan kitosan sebagai edible coating. Penelitian ini dilakukan untuk mengetahui perlakuan terbaik dalam pengaplikasian edible coating kitosan dengan mengeksplor karakteristik tahu sutra selama penyimpanan untuk memperpanjang umur simpan tahu sutra. Penelitian ini dirancang menggunakan Rancangan Acak Lengkap (RAL) dengan dua faktor terdiri atas 10 perlakuan dan pengulangan 3 kali. Perlakuan yang diaplikasikan yaitu menggunakan variasi konsentrasi kitosan 0,5%, 1%, dan 1,5% serta menggunakan waktu perendaman 5, 10, dan 15 menit. Hasil penelitian menunjukkan pemberian edible coating kitosan pada tahu sutra dengan variasi konsentrasi dan lama perendaman menghasilkan karakteristik tahu sutra yang berbeda-beda, berdasarkan hasil uji warna, kadar air, pH, dan organoleptik. Jenis perlakuan terbaik berdasarkan uji indeks efektivitas adalah tahu sutra 1%; 10' yaitu tahu sutra dengan konsentrasi kitosan 1% dan lama perendaman 10 menit dengan nilai hasil sebesar 0,823. Tahu sutra 1%; 10' pada hari ke-8 memiliki hasil pengujian warna L: 90,8; warna b: 11,5; kadar air: 73,34%; pH: 5,54; organoleptik warna: skor 6; organoleptik aroma: skor 6; organoleptik tekstur: skor 5,5; dan organoleptik keseluruhan: skor 6.
CORRELATION BETWEEN HEIGHT, BMI, MUAC WITH ANEMIA STATUS IN ADOLESCENT GIRLS
Authors: Muminah  , Budi Amalia Rize , Sudaryanti Lestari , Sulistiawati Sulistiawati 
Published: July 2024

Background: Anemia in adolescents is a health problem that needs immediate intervention in Indonesia. Anemia can caused by malnutrition. protein and iron deficiency will cause nutritional problems including stunted, thinness, and Mid Upper Arm Circumference (MUAC) < 23,5 cm. Protein and iron deficiency can interfere with the formation of hemoglobin resulting in anemia. This study aims to analyze the relationship between status based on height, Body Mass Index (BMI) and MUAC with anemia status at Mambaus Sholihin Islamic Boarding School in Gresik Regency. Method: This research is a quantitative observational analytic with the cross sectional method. The population was adolescent girls in Mambaus Sholihin Islamic Boarding School in Gresik Regency. The sample was 11th and 12th grade senior high school girls with a total of 141 respondents using the total sampling technique. The variables used in this research consisted of height, BMI, MUAC, and anemia. Height data was obtained by using microtoise, BMI using microtoise and scales, MUAC using tape measure plastic, and hemoglobin using the digital tool of Point of Care Testing (POCT) method. The research data were analyzed by chi square test with a contingency coefficient of 95%. Result: The results showed that out of 141 adolescent girls, 66.7% had normal height status, 23.4% were stunted, and 9.9% were severely stunted. In BMI status, 55.3% normal, 14.9% thinness, 15.6% overweight, and 14.2% obese. MUAC status was 79.4% with MUAC ≥ 23.5 cm and 20.6% with MUAC < 23.5 cm. Anemia status was 51.8% frail and 48.2% not anemic. After the chi square test, the significance value was obtained (p=0.006), which means that statistically there was a significant relationship between height and anemia, (p=0.003) there was a significant relationship between BMI and anemia, and (p=0.01) there was a significant relationship between MUAC and anemia. Conclusion: There is a relationship between nutritional status based on height, BMI, and MUAC with anemia status in adolescent girls at Mambaus Sholihin Islamic Boarding School in Gresik Regency.
Peningkatan Hasil Pembelajaran Menulis Surat Lamaran Pekerjaan dengan Metode Tutor Sebaya pada Siswa Kelas XII TP SMK PUI Gegesik Tahun Pelajaran 2023/2024
Authors: Komalasari Komalasari , Efendi Irfan , Fajri Khoirul 
Published: July 2024

<p>Penelitian ini bertujuan untuk menginvestigasi hasil pembelajaran dengan metode tutor sebaya dalam materi pembelajaran menulis surat lamaran pekerjaan pada siswa kelas XII Teknik Pengelasan. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK) atau Classroom Action Research (CAR). Subjek dalam penelitian ini adalah peserta didik kelas XII Teknik Pengelasan SMK PUI Gegesik tahun pelajaran 2023/2024 yang berjumlah 28 peserta didik. Gegesik. Teknik pengumpulan data pada penelitian ini adalah menggunakan tes hasil belajar. Data dianalisis dengan teknik analisis deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa pembelajaran dengan metode tutor sebaya dapat meningkatkan hasil pembelajaran dalam materi pembelajaran menulis surat lamaran pekerjaan dengan metode tutor sebaya pada siswa kelas XII TP SMK PUI Gegesik tahun pelajaran 2023/2024. Pada saat dilakukannya siklus II didapatkan peningkatan nilai rata-rata sebesar 86,5 dibandingkan pada siklus I nilai rata-ratanya sebesar 74. </p>
Kesiapan Kabupaten Sumbawa Barat Pada Program Smart Village: Tinjauan Domain Smart Economy
Authors: Jayadi Agus , Sofyan Ahdi Topan , Lillah Muhammad Afif , Ramdhani Ariesta 
Published: July 2024

<p>Penelitian ini bertujuan untuk menganalisis bagaimana kesiapan Kecamatan Taliwang, Kabupaten Sumbawa Barat menuju implementasi program desa pintar (smart village), secara spesifik pada aspek smart economi Penelitian menerapakan metode survei secara online, melalui angket skala Likert (sangat setuju, setuju, kurang setuju, dan sangat tidak setuju) Responden penelitian terdiri dari 114 orang di Kabupaten Sumbawa Barat dari berbagai bidang pekerjaan, mencakup 47 desa dari tujuh kecamatan di KSB. Hasil penelitian menunjukkan beberapa aspek yang diukur mendapatkan respon kurang disetujui oleh responden pada kode EB2, EB3, dan EA. Ketiganya menyatakan tentang kesiapan pemerintah desa di KSB dalam meningkatkan pemberdayaan ekonomi masyarakat (empowerment), mewujudkan transaksi ekonomi berbasis digital di tingkat desa, dan mengadopsi teknologi informasi &amp; komunikasi untuk meningkatkan lapangan pekerjaan dan kesejahteraan desa di wilayah KSB melalui pembangunan ekonomi yang berdaya saing dan transaksi keuangan yang non tunai. Hasil analisis dengan model Rasch dari kriteria responden, diperoleh hasil berupa 1) Sangat Tidak Setuju 2%; 2) Kurang Setuju 6%; 3) Setuju 46%; dan 4) Sangat Setuju 46%. Dapat disimpulkan bahwa sebagian besar masyarakat KSB telah siap dan setuju dengan program Pemerintah KSB dalam membangun kota pintar, khususnya pada doamin smart smart economy.</p>
Analisis Pengaruh Lokasi, Promosi, dan Kualitas Pelayanan Terhadap Keputusan Konsumen Memebli Produk PT Indomarco Prismatama (Studi Kasus di Minimarket Indomaret Kecamatan Kraton Pasuruan)
Authors: Qomariah Nur 
Published: July 2024

<p>Tujuan dalam penelitian ini adalah untuk menganalisis dan membahas pengaruh lokasi, promosi dan kualitas pelayanan terhadap keputusan pembelian pada PT Indomarco Prismatama. Penelitian ini menerapkan metode penelitian kuantitatif dengan desain korelasional dengan teknik analisis regresi linier berganda. Data yang diperoleh melalui kuesioner kepada konsumen dari PT Indomarco Prismatama. Responden dalam penelitian ini adalah konsumen dari PT Indomarco Prismatama sebanyak 100 responden, dengan menggunakan teknik non random sampling. Hasil penelitian menunjukkan dengan menggunakan model analisis regresi berganda, maka dapat disimpulkan apabila Indomaret mampu menyediakan lokasi yang mudah dijangkau, terletak di pusat keramaian dan lokasi parkir yang aman, maka konsumen akan suka melakukan pembelian di Indomaret. Proses penyebaran informasi atau promosi yang dilakukan Indomaret berupa hadiah langsung, kupon undian dan potongan harga mampu mempengaruhi atau membujuk konsumen untuk membeli produk yang ditawarkan dan meningkatkan penjualan Indomaret. Dapat disimpulkan bahwa lokasi, promosi dan kualitas pelayanan berpengaruh terhadap keputusan pembelian pada PT Indomarco Prismatama.</p>
Development of Problem Based Learning (PBL) Modules Oriented to Science, Environment, Technology and Society (SETS) on Acid-Base Material
Authors: Wulandari Mustika , Hakim Fachri 
Published: July 2024

<p>Industri kerajinan tenun ikat menghasilkan limbah cair yang mengandung zat warna dan langsung dibuang ke aliran sungai yang menimbulkan pencemaran lingkungan air sungai. Tujuan penelitian ini untuk menghasilkan modul pembelajaran berbasis PBL berorientasi SETS pada materi asam basa dan mengetahui kualitas modul yang dikembangkan. Metode pengembangan yang digunakan dalam penelitian ini adalah model ADDIE yaitu <em>analysis,</em><em> </em><em>design</em>, <em>development, implementation,</em><em> </em>dan<em> </em><em>evaluation.</em><em> </em>Hasil validasi oleh validator ahli materi dan ahli media memperoleh persentase rata-rata sebesar 86,8% termasuk dalam kategori sangat valid. Hasil uji kelayakan pengguna yang dilakukan dengan uji coba skala kecil oleh peserta didik memperoleh persentase rata-rata sebesar 87,40% termasuk kategori sangat valid. Hasil uji keterbacaan oleh peserta didik terhadap modul yang dikembangkan memperoleh rata-rata skor sebesar 92,9% tergolong dalam kategori tinggi. Berdasarkan hasil dari penilaian, modul berbasis PBL berorientasi SETS yang dikembangkan ini memiliki kategori sangat layak untuk diuji cobakan dalam kelas besar.</p><br /><div id="pip-toast"> </div>
Efektivitas dan Pemanfaatan Kearifan Lokal Ekstrak Buah Buni (Antidesma Bunius (L) SPRENG) Sebagai Indikator Alami Asam Basa
Authors: Rahma Auliya Fitria , Roudloh Azka Zakiyyatur , Mulyanti Sri 
Published: July 2024

<p>Antosianin sebagai kelompok senyawa pigmen alami yang terdapat pada buah buni, belum sepenuhnya dieksplorasi atau dimanfaatkan secara optimal dalam berbagai aplikasi meskipun keberadaannya telah diidentifikasi. Tujuan eksperimen ini adalah untuk mengetahui efektivitas dan potensi ekstrak buah buni sebagai indikator alami dalam proses titrasi asam basa. Dalam penelitian ini, observasi dilakukan terhadap kandungan antosianin pada buah buni dalam tiga kondisi (matang, setengah matang, mentah) terhadap variasi nilai pH larutan asam dan basa. Pengujian dilakukan pada ekstrak buah buni menggunakan bahan-bahan asam (jeruk nipis, blimbing wuluh, cuka, jeruk orange) dan basa (sabun cuci piring, sabun mandi cair, deterjen, soda kue) dengan hasil ektraksi 30 gram buah buni.Berdasarkan hasil eksperimen, buah buni dalam kondisi matang lebih efektif digunakan karena mengalami perubahan warna yang sesuai. Pada ph 2-3 buah buni menghasilkan warna merah pekat-merah kecoklatan, ph 5-6 menghasilkan warna merah pudar-merah keunguan sedangkan pada ph 8-10 memberikan warna biru pekat-hjau kekuningan<em>.</em>Kesimpulan penelitian ini menunjukkan bahwa ekstrak buah buni dapat berfungsi sebagai indikator alami yang efektif dalam titrasi asam basa dengan kandungan antosianin yang memberikan warna yang bervariasi, terutama pada kondisi buah buni yang matang.</p><div id="pip-toast"> </div><div id="pip-toast"> </div>