bluuebunny/crossref_metadata_2025_split huggingface dataset:
CANONISING SAN CARLO: SERMONISING, THE SOUNDING WORD, AND IMAGE CONSTRUCTION IN THE MUSIC FOR CARLO BORROMEO
Authors: Getz Christine 
Published: September 2015

AbstractThis essay examines the role of the hymns, the sacred polyphony by Vincenzo Pellegrini and Andrea Cima, and the spiritual madrigals of Giovanni Battista Porta in promoting the officially sanctioned image of Carlo Borromeo after his elevation to the status of ‘beato’ and following his canonisation. It further considers how the musical structures that characterised these works may have derived from other modes of textual presentation, in particular the sermons used to deliver the message in comparable settings. Finally, it explores how various styles of performance may have subliminally underscored certain constructed images of the archbishop and his city that developed in the years leading to the canonisation. San Carlo’s continued currency depended upon redefining his image according to changing social constructs. With the plague of 1630, Michel’angelo Grancini’s O sol & salus Carole returns to the event with which Borromeo’s sanctity was most closely identified, namely the penitential processions of 1576.
Calcium ions open a selectivity filter gate during activation of the MthK potassium channel
Authors: Posson David J. , Rusinova Radda , Andersen Olaf S. , Nimigean Crina M. 
Published: September 2015

AbstractIon channel opening and closing are fundamental to cellular signalling and homeostasis. Gates that control K+ channel activity were found both at an intracellular pore constriction and within the selectivity filter near the extracellular side but the specific location of the gate that opens Ca2+-activated K+ channels has remained elusive. Using the Methanobacterium thermoautotrophicum homologue (MthK) and a stopped-flow fluorometric assay for fast channel activation, we show that intracellular quaternary ammonium blockers bind to closed MthK channels. Since the blockers are known to bind inside a central channel cavity, past the intracellular entryway, the gate must be within the selectivity filter. Furthermore, the blockers access the closed channel slower than the open channel, suggesting that the intracellular entryway narrows upon pore closure, without preventing access of either the blockers or the smaller K+. Thus, Ca2+-dependent gating in MthK occurs at the selectivity filter with coupled movement of the intracellular helices.
Entrainment of mouse peripheral circadian clocks to <24 h feeding/fasting cycles under 24 h light/dark conditions
Authors: Hamaguchi Yutaro , Tahara Yu , Kuroda Hiroaki , Haraguchi Atsushi , Shibata Shigenobu 
Published: September 2015

AbstractThe circadian clock system in peripheral tissues can endogenously oscillate and is entrained by the light-dark and fasting-feeding cycles in mammals. Although the system’s range of entrainment to light-dark cycles with a non-24 h (<24 h) interval has been studied, the range of entrainment to fasting-feeding cycles with shorter periods (<24 h) has not been investigated in peripheral molecular clocks. In the present study, we measured this range by monitoring the mouse peripheral PER2::LUCIFERASE rhythm in vivo at different periods under each feeding cycle (Tau (T) = 15–24 h) under normal light-dark conditions. Peripheral clocks could be entrained to the feeding cycle with T = 22–24 h, but not to that with T = 15–21 h. Under the feeding cycle with T = 15–18 h, the peripheral clocks oscillated at near the 24-h period, suggesting that they were entrained to the light-dark cycle. Thus, for the first time, we demonstrated the range of entrainment to the non-24 h feeding cycle and that the circadian range (T = 22–24 h) of feeding stimulus is necessary for peripheral molecular clock entrainment under light-dark cycles.
Reducing the stress of drug administration: implications for the 3Rs
Authors: Stuart Sarah A. , Robinson Emma S.J. 
Published: September 2015

AbstractRestraint in animals is known to cause stress but is used during almost all scientific procedures in rodents, representing a major welfare and scientific issue. Administration of substances, a key part of most scientific procedures, almost always involves physical restraint of the animal. In this study, we developed a method to inject substances to rats using a non-restrained technique. We then compared the physiological, behavioral and emotional impacts of restrained versus non-restrained injection procedures. Our results highlight the negative welfare implications associated with physical restraint and demonstrate a method which can be used to avoid this. Our work shows how adopting strategies that avoid restraint can minimize a widespread source of stress in laboratory animals and improve welfare through refinement.
Dynamic graphene filters for selective gas-water-oil separation
Authors: Bong Jihye , Lim Taekyung , Seo Keumyoung , Kwon Cho-Ah , Park Ju Hyun , Kwak Sang Kyu , Ju Sanghyun 
Published: September 2015

AbstractSelective filtration of gas, water and liquid or gaseous oil is essential to prevent possible environmental pollution and machine/facility malfunction in oil-based industries. Novel materials and structures able to selectively and efficiently filter liquid and vapor in various types of solutions are therefore in continuous demand. Here, we investigate selective gas-water-oil filtration using three-dimensional graphene structures. The proposed approach is based on the adjustable wettability of three-dimensional graphene foams. Three such structures are developed in this study; the first allows gas, oil and water to pass, the second blocks water only and the third is exclusively permeable to gas. In addition, the ability of three-dimensional graphene structures with a self-assembled monolayer to selectively filter oil is demonstrated. This methodology has numerous potential practical applications as gas, water, and/or oil filtration is an essential component of many industries.
Size-controllable Ni5TiO7 nanowires as promising catalysts for CO oxidation
Authors: Jiang Yanan , Liu Baodan , Yang Lini , Yang Bing , Liu Xiaoyuan , Liu Lusheng , Weimer Christian , jiang Xin 
Published: September 2015

AbstractNi5TiO7 nanowires with controllable sizes are synthesized using PEO method combined with impregnation and annealing at 1050oC in air, with adjustment of different concentrations of impregnating solution to control the dimension of nanowires. The resulting nanowires are characterized in details using X-ray diffraction, scanning electron microscopy, transmission electron microscopy and energy dispersive X-ray analysis. In addition, the CO catalytic oxidation performance of the Ni5TiO7 nanowires is investigated using a fixed-bed quartz tubular reactor and an on-line gas chromatography system, indicating that the activity of this catalytic system for CO oxidation is a strong dependency upon the nanocrystal size.When the size of the Ni5TiO7 nanowires is induced from 4 μm to 50 nm, the corresponding maximum conversion temperature is lowered by ~100 oC.
Down-regulation of microRNA-144 in air pollution-related lung cancer
Authors: Pan Hong-Li , Wen Zhe-Sheng , Huang Yun-Chao , Cheng Xin , Wang Gui-Zhen , Zhou Yong-Chun , Wang Zai-Yong , Guo Yong-Qing , Cao Yi , Zhou Guang-Biao 
Published: September 2015

AbstractAir pollution has been classified as a group 1 carcinogen in humans, but the underlying tumourigenic mechanisms remain unclear. In Xuanwei city of Yunnan Province, the lung cancer incidence is among the highest in China, owing to severe air pollution generated by the combustion of smoky coal, providing a unique opportunity to dissect lung carcinogenesis. To identify abnormal miRNAs critical for air pollution-related tumourigenesis, we performed microRNA microarray analysis in 6 Xuanwei non-small cell lung cancers (NSCLCs) and 4 NSCLCs from control regions where smoky coal was not used. We found 13 down-regulated and 2 up-regulated miRNAs in Xuanwei NSCLCs. Among them, miR-144 was one of the most significantly down-regulated miRNAs. The expanded experiments showed that miR-144 was down-regulated in 45/51 (88.2%) Xuanwei NSCLCs and 34/54 (63%) control region NSCLCs (p = 0.016). MiR-144 interacted with the oncogene Zeb1 at 2 sites in its 3′ untranslated region and a decrease in miR-144 resulted in increased Zeb1 expression and an epithelial mesenchymal transition phenotype. Ectopic expression of miR-144 suppressed NSCLCs in vitro and in vivo by targeting Zeb1. These results indicate that down-regulation of miR-144 is critical for air pollution-related lung cancer and the miR-144-Zeb1 signalling pathway could represent a potential therapeutic target.
Effect of band-aligned double absorber layers on photovoltaic characteristics of chemical bath deposited PbS/CdS thin film solar cells
Authors: Ho Yeon Deuk , Chandra Mohanty Bhaskar , Lee Seung Min , Soo Cho Yong 
Published: September 2015

AbstractHere we report the highest energy conversion efficiency and good stability of PbS thin film-based depleted heterojunction solar cells, not involving PbS quantum dots. The PbS thin films were grown by the low cost chemical bath deposition (CBD) process at relatively low temperatures. Compared to the quantum dot solar cells which require critical and multistep complex procedures for surface passivation, the present approach, leveraging the facile modulation of the optoelectronic properties of the PbS films by the CBD process, offers a simpler route for optimization of PbS-based solar cells. Through an architectural modification, wherein two band-aligned junctions are stacked without any intervening layers, an enhancement of conversion efficiency by as much as 30% from 3.10 to 4.03% facilitated by absorption of a wider range of solar spectrum has been obtained. As an added advantage of the low band gap PbS stacked over a wide gap PbS, the devices show stability over a period of 10 days.
Impact of Substrate and Bright Resonances on Group Velocity in Metamaterial without Dark Resonator
Authors: Hokmabadi Mohammad Parvinnezhad , Kim Ju-Hyung , Rivera Elmer , Kung Patrick , Kim Seongsin M. 
Published: September 2015

AbstractManipulating the speed of light has never been more exciting since electromagnetic induced transparency and its classical analogs led to slow light. Here, we report the manipulation of light group velocity in a terahertz metamaterial without needing a dark resonator, but utilizing instead two concentric split-ring bright resonators (meta-atoms) exhibiting a bright Fano resonance in close vicinity of a bright Lorentzian resonance to create a narrowband transmittance. Unlike earlier reports, the bright Fano resonance does not stem from an asymmetry of meta-atoms or an interaction between them. Additionally, we develop a method to determine the metamaterial “effective thickness”, which quantifies the influence of the substrate on the metamaterial response and has remained challenging to estimate so far. By doing so, very good agreement between simulated and measured group delays and velocities is accomplished. The proposed structure and method will be useful in designing optical buffers, delay lines and ultra-sensitive sensors.
Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components
Authors: McCue Hannah V. , Chen Xi , Barclay Jeff W. , Morgan Alan , Burgoyne Robert D. 
Published: September 2015

AbstractCysteine string protein (CSP) is a chaperone of the Dnaj/Hsp40 family of proteins and is essential for synaptic maintenance. Mutations in the human gene encoding CSP, DNAJC5, cause adult neuronal ceroid lipofucinosis (ANCL) which is characterised by progressive dementia, movement disorders, seizures and premature death. CSP null models in mice, flies and worms have been shown to also exhibit similar neurodegenerative phenotypes. Here we have explored the mechanisms underlying ANCL disease progression usingCaenorhaditis elegansmutant strains ofdnj-14, the worm orthologue of DNAJC5. Transcriptional profiling of these mutants compared to control strains revealed a broad down-regulation of ubiquitin proteasome system (UPS)-related genes, in particular, components of multimeric RING E3 ubiquitin ligases including F-Box, SKR and BTB proteins. These data were supported by the observation thatdnj-14mutant worm strains expressing a GFP-tagged ubiquitin fusion degradation substrate exhibited decreased ubiquitylated protein degradation. The results indicate that disruption of an essential synaptic chaperone leads to changes in expression levels of UPS-related proteins which has a knock-on effect on overall protein degradation inC. elegans.The specific over-representation of E3 ubiquitin ligase components revealed in our study, suggests that proteins and complexes upstream of the proteasome itself may be beneficial therapeutic targets.
Peptide bonds affect the formation of haloacetamides, an emerging class of N-DBPs in drinking water: free amino acids versus oligopeptides
Authors: Chu Wenhai , Li Xin , Gao Naiyun , Deng Yang , Yin Daqiang , Li Dongmei , Chu Tengfei 
Published: September 2015

AbstractHaloacetamides (HAcAms), an emerging class of nitrogenous disinfection by-products (N-DBPs) of health concern, have been frequently identified in drinking waters. It has long been appreciated that free amino acids (AAs), accounting for a small fraction of the dissolved organic nitrogen (DON) pool, can form dichloroacetamide (DCAcAm) during chlorination. However, the information regarding the impacts of combined AAs, which contribute to the greatest identifiable DON portion in natural waters, is limited. In this study, we compared the formation of HAcAms from free AAs (tyrosine [Tyr] and alanine [Ala]) and combined AAs (Tyr-Ala, Ala-Tyr, Tyr-Tyr-Tyr, Ala-Ala-Ala) and found that HAcAm formation from the chlorination of AAs in combined forms (oligopeptides) significantly exhibited a different pattern with HAcAm formation from free AAs. Due to the presence of peptide bonds in tripeptides, Tyr-Tyr-Tyr and Ala-Ala-Ala produced trichloroacetamide (TCAcAm) in which free AAs was unable to form TCAcAm during chlorination. Moreover, peptide bond in tripeptides formed more tri-HAcAms than di-HAcAms in the presence of bromide. Therefore, the peptide bond may be an important indicator to predict the formation of specific N-DBPs in chlorination. The increased use of algal- and wastewater-impacted water as drinking water sources will increase health concerns over exposure to HAcAms in drinking water.
Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder
Authors: Scott John W. , Park Elizabeth , Rodriguiz Ramona M. , Oakhill Jonathan S. , Issa Samah M. A. , O’Brien Matthew T. , Dite Toby A. , Langendorf Christopher G. , Wetsel William C. , Means Anthony R. , Kemp Bruce E. 
Published: September 2015

AbstractMutations that reduce expression or give rise to a Thr85Ser (T85S) mutation of Ca2+-CaM-dependent protein kinase kinase-2 (CaMKK2) have been implicated in behavioural disorders such as anxiety, bipolar and schizophrenia in humans. Here we report that Thr85 is an autophosphorylation site that endows CaMKK2 with a molecular memory that enables sustained autonomous activation following an initial, transient Ca2+ signal. Conversely, autophosphorylation of Ser85 in the T85S mutant fails to generate autonomous activity but instead causes a partial loss of CaMKK2 activity. The loss of autonomous activity in the mutant can be rescued by blocking glycogen synthase kinase-3 (GSK3) phosphorylation of CaMKK2 with the anti-mania drug lithium. Furthermore, CaMKK2 null mice representing a loss of function model the human behavioural phenotypes, displaying anxiety and manic-like behavioural disturbances. Our data provide a novel insight into CaMKK2 regulation and its perturbation by a mutation associated with behavioural disorders.
Reduction modulo 𝑝 of certain semi-stable representations
Authors: Park Chol 
Published: September 2015

Let

p
>
3

p>3

be a prime number and let

G

Q

p

G_{\mathbb {Q}_{p}}

be the absolute Galois group of

Q

p

\mathbb {Q}_{p}

. In this paper, we find Galois stable lattices in the

3
3

-dimensional irreducible semi-stable non-crystalline representations of

G

Q

p

G_{\mathbb {Q}_{p}}

with Hodge–Tate weights

(
0
,
1
,
2
)

(0,1,2)

by constructing the corresponding strongly divisible modules. We also compute the Breuil modules corresponding to the mod

p
p

reductions of these strongly divisible modules and determine which of the original representations has an absolutely irreducible mod

p
p

reduction.
Approximately independent linkage disequilibrium blocks in human populations
Authors: Berisa Tomaz , Pickrell Joseph K. 
Published: September 2015

Abstract
Summary: We present a method to identify approximately independent blocks of linkage disequilibrium in the human genome. These blocks enable automated analysis of multiple genome-wide association studies.
Availability and implementation: code: http://bitbucket.org/nygcresearch/ldetect; data: http://bitbucket.org/nygcresearch/ldetect-data.
Contact: tberisa@nygenome.org
Supplementary information: Supplementary data are available at Bioinformatics online.
Sparse meta-analysis with high-dimensional data
Authors: He Qianchuan , Zhang Hao Helen , Avery Christy L. , Lin D. Y. 
Published: September 2015

AbstractMeta-analysis plays an important role in summarizing and synthesizing scientific evidence derived from multiple studies. With high-dimensional data, the incorporation of variable selection into meta-analysis improves model interpretation and prediction. Existing variable selection methods require direct access to raw data, which may not be available in practical situations. We propose a new approach, sparse meta-analysis (SMA), in which variable selection for meta-analysis is based solely on summary statistics and the effect sizes of each covariate are allowed to vary among studies. We show that the SMA enjoys the oracle property if the estimated covariance matrix of the parameter estimators from each study is available. We also show that our approach achieves selection consistency and estimation consistency even when summary statistics include only the variance estimators or no variance/covariance information at all. Simulation studies and applications to high-throughput genomics studies demonstrate the usefulness of our approach.
Physiological Effects of the Open Lung Approach in Patients with Early, Mild, Diffuse Acute Respiratory Distress Syndrome
Authors: Cinnella Gilda , Grasso Salvatore , Raimondo Pasquale , D’Antini Davide , Mirabella Lucia , Rauseo Michela , Dambrosio Michele 
Published: September 2015

AbstractAbstract
In 15 patients with early, mild, diffuse acute respiratory distress syndrome, application of an open lung approach (vs. a standard management protocol that does not target an “open” lung) resulted in lower driving pressure, improved oxygenation, and more homogeneous distribution of ventilation (assessed by electric impedance tomography).

Background
To test the hypothesis that in early, mild, acute respiratory distress syndrome (ARDS) patients with diffuse loss of aeration, the application of the open lung approach (OLA) would improve homogeneity in lung aeration and lung mechanics, without affecting hemodynamics.

Methods
Patients were ventilated according to the ARDS Network protocol at baseline (pre-OLA). OLA consisted in a recruitment maneuver followed by a decremental positive end-expiratory pressure trial. Respiratory mechanics, gas exchange, electrical impedance tomography (EIT), cardiac index, and stroke volume variation were measured at baseline and 20 min after OLA implementation (post-OLA). Esophageal pressure was used for lung and chest wall elastance partitioning. The tomographic lung image obtained at the fifth intercostal space by EIT was divided in two ventral and two dorsal regions of interest (ROIventral and ROIDorsal).

Results
Fifteen consecutive patients were studied. The OLA increased arterial oxygen partial pressure/inspired oxygen fraction from 216 ± 13 to 311 ± 19 mmHg (P < 0.001) and decreased elastance of the respiratory system from 29.4 ± 3 cm H2O/l to 23.6 ± 1.7 cm H2O/l (P < 0.01). The driving pressure (airway opening plateau pressure − total positive end-expiratory pressure) decreased from 17.9 ± 1.5 cm H2O pre-OLA to 15.4 ± 2.1 post-OLA (P < 0.05). The tidal volume fraction reaching the dorsal ROIs increased, and consequently the ROIVentral/Dorsal impedance tidal variation decreased from 2.01 ± 0.36 to 1.19 ± 0.1 (P < 0.01).

Conclusions
The OLA decreases the driving pressure and improves the oxygenation and lung mechanics in patients with early, mild, diffuse ARDS. EIT is useful to assess the impact of OLA on regional tidal volume distribution.
Noninvasive Measurement of Cerebral Blood Flow Under Anesthesia Using Arterial Spin Labeling MRI: A Pilot Study
Authors: Venkatraghavan Lashmi , Poublanc Julien , Bharadwaj Suparna , Sobczyk Olivia , Crawley Adrian P. , Mandell Daniel M. , Mikulis David J. , Fisher Joseph A. 
Published: September 2015

Background:
Cerebral ischemia plays a major role in pathophysiology of the injured brain. Most of the currently available methods of cerebral blood flow (CBF) monitors are either indirect measure of CBF or needing radioactive agents for data acquisition. Arterial spin labeling magnetic resonance imaging (ASL-MRI) is a noninvasive method of measuring CBF. The aim of our study was to determine the differences in the CBF values between propofol and sevoflurane anesthesia using ASL-MRI technique in mechanically ventilated patients with cerebrovascular disease.

Methods:
After ethics board approval and informed consent, we measured CBF in 4 patients with moyamoya disease, using a pseudo-continuous 3D ASL sequence available on a 3.0 T MRI scanner. Patients were anesthetized first with sevoflurane (1 MAC) and then anesthesia was converted to total intravenous anesthesia with propofol (100 to 125 μg/kg/min). When the patient was in a steady state with respect to anesthesia and normocapnia (baseline PETCO2), CBF was measured under both sevoflurane and propofol anesthesia.

Results:
Quantitative estimation of both global and regional CBF was successfully performed in all patients. The mean global CBF in gray and white matter of all patients under propofol anesthesia were 38.4 and 31.6 mL/100 g/min, respectively. Similar values under sevoflurane anesthesia were 56.6 mL/100 g/min for gray matter and 42.5 mL/100 g/min for white matter.

Conclusions:
ASL-MRI is a feasible, noninvasive method of quantitative estimation of global and regional CBF in mechanically ventilated patients under anesthesia. In this pilot study CBF was consistently greater with sevoflurane than with propofol.
Impact of Eye Cosmetics on the Eye, Adnexa, and Ocular Surface
Authors: Ng Alison , Evans Katharine , North Rachel V. , Jones Lyndon , Purslow Christine 
Published: September 2015

Abstract:
Despite the fact that cosmetic products undergo rigorous testing to ensure they are safe for human use, some users report mild discomfort following their application. The cutaneous changes, such as allergic dermatitis, are well reported, but the ocular changes associated with eye cosmetic use are less so. Some pigmented cosmetic products may accumulate within the lacrimal system and conjunctivae over many years of use, but immediate reports of eye discomfort after application are most common. Changes to the tear film and its stability may occur shortly after application, and contact lens wearers can also be affected by lens spoliation from cosmetic products. Additionally, creams used in the prevention of skin aging are often applied around the eyes, and retinoids present in these formulations can have negative effects on meibomian gland function and may be a contributing factor to dry eye disease. The aim of this review is to summarize current knowledge regarding the impact of cosmetic products on the eye, ocular surface, and tear film.