bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nursing Patients with Ventricular Assist Devices: An Interpretive Description
Authors: Gibson Jennifer A. , Henderson Angela , Jillings Carol , Kaan Annemarie 
Published: June 2013

Context Although researchers have studied the experience of caring for patients with ventricular assist devices from the perspective of family caregivers, few reports address the experience of nursing patients with such devices. Objective To investigate the experience of nursing patients who have a ventricular assist device. Design A qualitative approach called interpretive description was used to conduct semistructured, 1-on-1 interviews. Participants Six registered nurses with a range of clinical experiences were interviewed in a 1-year period from 2009 to 2010. Data were transcribed and analyzed by the researcher in conjunction with a research team. Results Four distinct themes were interpreted from the interview data: exclusive knowledge, human connection, ethics, and interdisciplinary stress and technology. Conclusion Nursing patients who have a ventricular assist device is a complex experience. Nurses develop expert knowledge that is related to direct exposure to patients; this unique knowledge should be formally considered in team decision making. Nursing care of patients who have a ventricular assist device also has features that might result in overconnected nurse-patient relationships. Closely connected nurse-patient relationships intensified the emotional difficultly of experiences of exposure to illness or suffering, or exposure to an unpredictable dying trajectory. Nursing patients with ventricular assist devices can be difficult, and nursing leaders should be aware of the emotional reactions that can result from direct exposure to patients who might be perceived as very ill or suffering. Institutions with ventricular assist device programs should consider providing emotional support for health care workers who find this type of work emotionally difficult.
Prenatal Exposure to Ambient Air Pollution and Cerebral Palsy
Authors: Zhang Yu , Hu Yuhong , Talarico Robert , Qiu Xinye , Schwartz Joel , Fell Deshayne B. , Oskoui Maryam , Lavigne Eric , Messerlian Carmen 
Published: July 2024

ImportanceAir pollution is associated with structural brain changes, disruption of neurogenesis, and neurodevelopmental disorders. The association between prenatal exposure to ambient air pollution and risk of cerebral palsy (CP), which is the most common motor disability in childhood, has not been thoroughly investigated.ObjectiveTo evaluate the associations between prenatal residential exposure to ambient air pollution and risk of CP among children born at term gestation in a population cohort in Ontario, Canada.Design, Setting, and ParticipantsPopulation-based cohort study in Ontario, Canada using linked, province-wide health administrative databases. Participants were singleton full term births (≥37 gestational weeks) born in Ontario hospitals between April 1, 2002, and March 31, 2017. Data were analyzed from January to December 2022.ExposuresWeekly average concentrations of ambient fine particulate matter with a diameter 2.5 μm (PM2.5) or smaller, nitrogen dioxide (NO2), and ozone (O3) during pregnancy assigned by maternal residence reported at delivery from satellite-based estimates and ground-level monitoring data.Main outcome and measuresCP cases were ascertained by a single inpatient hospitalization diagnosis or at least 2 outpatient diagnoses for children from birth to age 18 years.ResultsThe present study included 1 587 935 mother-child pairs who reached term gestation, among whom 3170 (0.2%) children were diagnosed with CP. The study population had a mean (SD) maternal age of 30.1 (5.6) years and 811 745 infants (51.1%) were male. A per IQR increase (2.7 μg/m3) in prenatal ambient PM2.5 concentration was associated with a cumulative hazard ratio (CHR) of 1.12 (95% CI, 1.03-1.21) for CP. The CHR in male infants (1.14; 95% CI, 1.02-1.26) was higher compared with the CHR in female infants (1.08; 95% CI, 0.96-1.22). No specific window of susceptibility was found for prenatal PM2.5 exposure and CP in the study population. No associations or windows of susceptibility were found for prenatal NO2 or O3 exposure and CP risk.Conclusions and relevanceIn this large cohort study of singleton full term births in Canada, prenatal ambient PM2.5 exposure was associated with an increased risk of CP in offspring. Further studies are needed to explore this association and its potential biological pathways, which could advance the identification of environmental risk factors of CP in early life.
Expert consensus on quality control indicators for integrative medicine in rheumatoid arthritis (2023 version)
Authors: Tao Qingwen , Wang Jinping , Wang Zihan , Xu Yuan , Wang Jianming , Zhang Yingze 
Published: July 2024

AbstractThe rising costs of cancer care and subsequent medical financial hardship for cancer survivors and families are well documented in the United States. Less attention has been paid to employment disruptions and loss of household income after a cancer diagnosis and during treatment, potentially resulting in lasting financial hardship, particularly for working‐age adults not yet age‐eligible for Medicare coverage and their families. In this article, the authors use a composite patient case to illustrate the adverse consequences of cancer diagnosis and treatment for employment, health insurance coverage, household income, and other aspects of financial hardship. They summarize existing research and provide nationally representative estimates of multiple aspects of financial hardship and health insurance coverage, benefit design, and employee benefits, such as paid sick leave, among working‐age adults with a history of cancer and compare them with estimates among working‐age adults without a history of cancer from the most recently available years of the National Health Interview Survey (2019–2021). Then, the authors identify opportunities for addressing employment and health insurance coverage challenges at multiple levels, including federal, state, and local policies; employers; cancer care delivery organizations; and nonprofit organizations. These efforts, when informed by research to identify best practices, can potentially help mitigate the financial hardship associated with cancer.
Interface Characterization of Graphene‐Silicon Heterojunction Using Hg Probe Capacitance–Voltage Measurement
Authors: Wang Ting , Peng Songang , Jin Zhi , Hu Chen , Tian He 
Published: July 2024

AbstractInvestigating the intrinsic properties of the Schottky interface between graphene and 3D bulk silicon is crucial. However, the semiconductor technology introduces extra doping and defects in graphene, which significantly disturbs the property of the graphene‐silicon interface. Here, the interface parameters of graphene/n‐Si heterojunction are derived by the damage‐free Hg‐probe capacitance–voltage measurement. Due to its low‐density states, the Fermi level of graphene can be pushed upward, which results in a lower Schottky barrier height (ΦB0) of Hg/graphene/n‐Si (HGS) heterostructure than that of Hg/n‐Si (HS) structure. Additionally, the series resistance (Rs) of HGS becomes lower than that of HS, which can be attributed to the narrowed depletion layer width (WD) and the decreased interface state density (Nit). Furthermore, the frequency characteristic is also investigated. Because of the weak interface state charge trapping–detrapping process and the decreased Nit at high frequency, electrons will accumulate in graphene, and the Fermi level will be pushed up. Hence, the ΦB0 and Rs will decrease with increasing frequency. This study contributes to a deep understanding of the graphene/silicon heterojunction interfaces, which is crucial for designing and optimizing the new electronic and optoelectronic devices based on 2D/3D heterostructure.
Biobased Polyethylene Furanoate: Production Processes, Sustainability, and Techno‐Economics
Authors: Sanders John H. , Cunniffe Julia , Carrejo Edgar , Burke Cullen , Reynolds Autumn M. , Dey Shaikat Chandra , Islam Md. Nazrul , Wagner Owen , Argyropoulos Dimitris 
Published: July 2024

AbstractPolyethylene furanoate (PEF) is a biobased plastic, similar to synthetic polyethylene terephthalate (PET), which is produced from the platform chemical 2,5‐hydroxymethylfurfural (HMF). Much of the literature surrounding PEF is focused on unit processes, with little regard for their sustainability and economic viability. In this comprehensive critical review, the entire process of PEF production, from the feedstock to polymerization and upstream applications, is critically examined. Identification of individual pathways capable of producing PEF efficiently and with favorable properties while considering economic viability and environmental sustainability are presented. For each unit operation, recent technological developments are summarized, and recommendations are made based on process efficiency. The collection of the findings from both life cycle assessments (LCA) and techno‐economic analyses (TEA) facilitated the identification of pathways with the greatest potential for environmental sustainability and economic viability of PEF production.
Synthesis of Poly‐Pyrrole Nanotubes/Chromium Vanadate Composite as Wired Interlocks to Achieve an Asymmetric Supercapacitor Device with Scaled Electrochemical Energy Parameters
Authors: Jhanjhariya Neeru , Lata Suman 
Published: July 2024

AbstractHerein, a novel combination with a focused morphology is designed after synthesizing CrVO4 (CV) nanoparticles and poly‐pyrrole nanotubes (PNT or P) to prepare the interlocks of the composites of PNT and CrVO4 as 1PCV1, 1PCV2, 2PCV1, and 2PCV2 to study the supercapacitor application. Structural and spectral characterizations are perpetuated to confirm the synthesis of the samples. Results furnishing best energy storage are obtained for the intercalated composite 2PCV1 examined for three‐probe and two‐probe set‐up. The excel values for specific capacitance (Cs) for 2PCV1 concerning the Cyclic voltammetry (CV) cycle and Galvanostatic Charge Discharge (GCD) curve are 1745.60 F g−1 at 10 mV s−1 rate and 1545.62 F g−1 at 0.625 A g−1 current density studied along with interface controlled and transport‐controlled Cs with a contribution of 55.13% interface part and 44.87% transport part at 5 mV s−1 scan rate. Electrochemical Impedance Spectroscopy (EIS) study has provided 0.86 n‐factor with solution resistance Rs of 1.48 Ω, and a charge transfer resistance of 0.166 Ω. The respective specific power and specific energy values obtained through the two‐probe set‐up are also interestingly high 416.68 W kg−1 and 45.14 Wh kg−1 at 0.83 A g−1 current density. Also, the retention % in Cs values is studied by running 5000 continuous voltammetric cycles with 96.23% retention in supercapacitor device.
CircCFL1 Promotes TNBC Stemness and Immunoescape via Deacetylation‐Mediated c‐Myc Deubiquitylation to Facilitate Mutant TP53 Transcription
Authors: Wang Zekun , Li Yaming , Yang Jingwen , Sun Yuhan , He Yinqiao , Wang Yuping , Liang Yiran , Chen Xi , Chen Tong , Han Dianwen , Zhang Ning , Chen Bing , Zhao Wenjing , Wang Lijuan , Luo Dan , Yang Qifeng 
Published: July 2024

AbstractTriple‐negative breast cancer (TNBC) is the most malignant subtype of breast cancer. TP53, which has a mutation rate of ≈70%–80% in TNBC patients, plays oncogenic roles when mutated. However, whether circRNAs can exert their effects on TNBC through regulating mutant TP53 has not been well evaluated. In this study, circCFL1, which is highly expressed in TNBC cells and tissues and has prognostic potential is identified. Functionally, circCFL1 promoted the proliferation, metastasis and stemness of TNBC cells. Mechanistically, circCFL1 acted as a scaffold to enhance the interaction between HDAC1 and c‐Myc, further promoting the stability of c‐Myc via deacetylation‐mediated inhibition of K48‐linked ubiquitylation. Stably expressed c‐Myc further enhanced the expression of mutp53 in TNBC cells with TP53 mutations by directly binding to the promoter of TP53, which promoted the stemness of TNBC cells via activation of the p‐AKT/WIP/YAP/TAZ pathway. Moreover, circCFL1 can facilitate the immune escape of TNBC cells by promoting the expression of PD‐L1 and suppressing the antitumor immunity of CD8+ T cells. In conclusion, the results revealed that circCFL1 plays an oncogenic role by promoting the HDAC1/c‐Myc/mutp53 axis, which can serve as a potential diagnostic biomarker and therapeutic target for TNBC patients with TP53 mutations.
Mechanistic study of the effect of flexible fixation and load‐bearing stress environment on fracture healing and shaping
Authors: Li Xingfu , Deng Zhenhan , Lu Wei 
Published: July 2024

AbstractBackgroundThe biomechanical environment created by suture‐button fixation Latarjet is conducive to the healing and shaping of the transplanted coracoid, but its mechanism remains unclear. The latest research has found that the absence of stem cell chemokine (CXCL12) impeded bone regeneration in Sonic Hedgehog (SHH)‐deficient animals. However, whether the biomechanical environment affects SHH and CXCL12 function has not been studied.MethodsRat fracture models were constructed to simulate stress environments under non‐load‐bearing and load‐bearing conditions. The fracture healing and shaping, as well as the expression levels of SHH and CXCL12, were assessed through gross viewing, micro‐computed tomography (micro‐CT), and histochemical staining.ResultsUnder flexible fixation, the relative bone volume (BV/TV) of rats exposed to the load‐bearing stress environment was significantly higher than that of rats under a non‐load‐bearing stress environment (p ≤ 0.05). Adverse bone shaping was not observed in rats subjected to flexible fixation. The levels of SHH and CXCL12 in load‐bearing rats exhibited significant elevation (p ≤ 0.05). Under a load‐bearing stress environment, no significant difference was observed in the BV/TV between the flexible fixation group and the rigid fixation group (p ≥ 0.05), but there was excessive hyperplasia of the fracture callus in the rigid fixation group. The levels of SHH and CXCL12 in rats subjected to rigid fixation were significantly elevated (p ≤ 0.05).ConclusionsFlexible fixation and load‐bearing stress environment may contribute to bone healing and shaping by influencing the levels of SHH and CXCL12, suggested that this mechanism may be relevant to the healing and shaping of the transplanted coracoid after suture‐button fixation Latarjet.
Multiplexed and Quantitative Imaging of Live‐Cell Membrane Proteins by a Precise and Controllable DNA‐Encoded Amplification Reaction
Authors: Diao Nannan , Hou Jianing , Peng Xinyu , Wang Yaru , He Axin , Gao Haiyan , Yang Linlin , Guo Pei , Wang Junyan , Han Da 
Published: July 2024

AbstractAmplifying DNA conjugated affinity ligands can improve the sensitivity and multiplicity of cell imaging and play a crucial role in comprehensively deciphering cellular heterogeneity and dynamic changes during development and disease. However, the development of one‐step, controllable, and quantitative DNA amplification methods for multiplexed imaging of live‐cell membrane proteins is challenging. Here, we introduce the template adhesion reaction (TAR) method for assembling amplifiable DNA sequences with different affinity ligands, such as aptamers or antibodies, for amplified and multiplexed imaging of live‐cell membrane proteins with high quantitative fidelity. The precisely controllable TAR enables proportional amplification of membrane protein targets with variable abundances by modulating the concentration ratios of hairpin templates and primers, thus allowing sensitive visualization of multiple membrane proteins with enhanced signal‐to‐noise ratios (SNRs) without disturbing their original ratios. Using TAR, we achieved signal‐enhanced imaging of six proteins on the same live‐cell within 1–2 h. TAR represents an innovative and programmable molecular toolkit for multiplexed profiling of membrane proteins in live‐cells.
From Ultrafast Photoinduced Small Polarons to Cooperative and Macroscopic Charge‐Transfer Phase Transition
Authors: Privault G. , Hervé M. , Godin N. , Bertoni R. , Akagi S. , Kubicki J. , Tokoro H. , Ohkoshi S. , Lorenc M. , Collet Eric 
Published: July 2024

AbstractWe study by femtosecond infrared spectroscopy the ultrafast and persistent photoinduced phase transition of the Rb0.94Mn0.94Co0.06[Fe(CN)6]0.98 ⋅ 0.2H2O material, induced at room temperature by a single laser shot. This system exhibits a charge‐transfer based phase transition with a 75 K wide thermal hysteresis, centred at room temperature, from the low temperature Mn3+−N−C−Fe2+ tetragonal phase to the high temperature Mn2+−N−C−Fe3+ cubic phase. At room temperature, the photoinduced phase transition is persistent. However, the out‐of‐equilibrium dynamics leading to this phase is multi‐scale. Femtosecond infrared spectroscopy, particularly sensitive to local reorganizations through the evolution of the frequency of the N−C vibration modes with the different characteristic electronic states, reveals that at low laser fluence and on short time scale, the photoexcitation of the Mn3+−N−C−Fe2+ phase creates small charge‐transfer polarons [Mn2+−N−C−Fe3+]* within ≃250 fs. The local trapping of photoinduced intermetallic charge‐transfer is characterized by the appearance of a polaronic infrared band, due to the surrounding Mn2+−N−C−Fe2+ species. Above a threshold fluence, when a critical fraction of small CT‐polarons is reached, the macroscopic phase transition to the persistent Mn2+−N−C−Fe3+ cubic phase occurs within ≃ 100 ps. This non‐linear photo‐response results from elastic cooperativity, intrinsic to a switchable lattice and reminiscent of a feedback mechanism.
N‐Phenyl‐2‐Pyridone‐Derived Endoperoxide Suppressing both Lung Cancer and Idiopathic Pulmonary Fibrosis Progression by Three‐Pronged Action**
Authors: Wang Lei , Wu Hao , Liu Ziang , Sun Rensong , Li Yanping , Si Yu , Nie Yun , Qiao Yuan , Qian Xiao , Zhang Shengli , Li Guangzhe , Sun Wen , Pan Yue , Akkaya Engin U. 
Published: July 2024

AbstractWe report an endoperoxide compound (E5) which can deliver three therapeutic components by a thermal cycloreversion, namely, singlet oxygen, triplet oxygen and 3‐methyl‐N‐phenyl‐2‐pyridone (P5), thus targeting multiple mechanisms for treating non‐small cell lung cancer and idiopathic pulmonary fibrosis. In aqueous environment, E5 undergoes clean reaction to afford three therapeutic components with a half‐life of 8.3 hours without the generation of other by‐products, which not only achieves good cytotoxicity toward lung cancer cells and decreases the levels of hypoxia‐inducible factor 1α (HIF‐1α) protein, but also inhibits the transforming growth factor β1 (TGF‐β1) induced fibrosis in vitro. In vivo experiments also demonstrated the efficacy of E5 in inhibiting tumor growth and relieving idiopathic pulmonary fibrosis, while exhibiting good biocompatibility. Many lines of evidence reveal the therapeutic efficacy of singlet oxygen and 3‐methyl‐N‐phenyl‐2‐pyridone for these two lung diseases, and triplet oxygen could downregulate HIF‐1α and relieve tumor hypoxia which is a critical issue in photodynamic therapy (PDT). Unlike other combination therapies, in which multiple therapeutic agents are given in independent formulations, our work demonstrates single molecule endoperoxide prodrugs could be developed as new platforms for treatment of cancers and related diseases.
One‐Step Synthesis of Chiral 9,10‐Dihydrophenanthrenes via Ligand‐Enabled Enantioselective Cascade β,γ‐Diarylation of Acids
Authors: Sheng Tao , Kang Guowei , Zhang Tao , Meng Guangrong , Zhuang Zhe , Chekshin Nikita , Yu Jin‐Quan 
Published: July 2024

AbstractPd(II)‐catalyzed enantioselective C−H activation has emerged as a versatile platform for constructing point, axial, and planar chirality. Herein, we present an unexpected discovery of a Pd‐catalyzed enantioselective cascade β,γ‐methylene C(sp3)−H diarylation of free carboxylic acids using bidentate chiral mono‐protected amino thioether ligands (MPAThio), enabling one‐step synthesis of a complex chiral 9,10‐dihydrophenanthrene scaffolds with high enantioselectivity. In this process, two methylene C(sp3)−H bonds and three C(sp2)−H bonds were activated, leading to the formation of four C−C bonds and three chiral centers in one pot. A plausible catalytic pathway starts with enantioselective β,γ‐dehydrogenation to form chiral β,γ‐cyclohexene. Intriguingly, this olefin serves as a norbornene‐type reagent (presumably assisted by the carboxyl directing effect), relaying two successive Catellani arylation reactions and a C−H arylation reaction to furnish chiral 9,10‐dihydrophenanthrenes along with meta‐selective homocoupling products of iodoarene.
Iron‐catalyzed C‐7 Selective NH2 Amination of Indoles
Authors: Wang Zhan‐Lin , Cheng Jin‐Kai , Wang Fei 
Published: July 2024

Abstract7‐Aminoindoles are important synthetic intermediates to a broad range of bioactive molecules. Transition metal‐catalyzed directed C−H amination is among the most straightforward route for their synthesis, whereas methods that could directly incorporate an NH2 group in a highly selective manner remains elusive. Moreover, there is still high demand for the development of earth‐abundant metal catalysis for such attractive reactivity. We present here the first C‐7 selective NH2 amination of indoles through a directed homolytic aromatic substitution (HAS) with iron‐aminyl radical. The reaction exhibits broad substrate scope, tolerates variety of functional groups, and is readily scalable with catalyst loading down to 0.1 mol % and turnover number (TON) up to 4500.
Spontaneous Transition between Multiple Conductance States and Rectifying Behaviors in an Artificial Single‐Molecule Funnel
Authors: Lin Jia‐Fen , Wang Xu‐Dong , Ao Yu‐Fei , Wang Qi‐Qiang , Wang De‐Xian 
Published: July 2024

AbstractIt has long been an aspirational goal to create artificial channel structures that replicate the feat achieved by ion channel proteins. Biological ion channels occasionally demonstrate multiple conductance states (known as subconductance), remaining a challenging property to achieve in artificial channel molecules. We report a funnel‐shaped single‐molecule channel constructed by an electron‐deficient macrocycle and two electron‐deficient aromatic imide arms. Planar lipid bilayer measurements reveal distinct current recordings, including a closed state, two conducting states, and spontaneous transitions between the three states, resembling the events seen in biological ion channels. The transitions result from conformational changes induced by chloride transport in the channel molecule. Both opening states show a non‐linear and rectifying I–V relationship, indicating voltage‐dependent transport due to the asymmetrical channel structure. This work could enhance our understanding of ion permeation and channel opening mechanism.