bluuebunny/crossref_metadata_2025_split huggingface dataset:
The stories of social entrepreneurs
Authors: Roundy Philip 
Published: November 2014

Purpose– The purpose of this study is to focus on how narratives are used to acquire social venture resources. Social entrepreneurship is a phenomenon of increasing significance. A key challenge for social ventures is resource acquisition. However, how social entrepreneurs gather the resources necessary to grow their organizations is not clear.Design/methodology/approach– This topic is examined using a multi-study, inductive, theory-building design based on 121 interviews, observation and archival data. In Study 1, 75 entrepreneurs, investors and ancillary participants were interviewed in the social enterprise sector. In Study 2, case studies of eight technology-focused social ventures were constructed.Findings– The result of this study is a framework explaining how differences in entrepreneurs’ narrative tactics and characteristics are associated with differences in their resource acquisition success. Specifically, from Study 1, this paper develops a typology of social enterprise narratives, identifies three narrative-types (personal, social-good and business) and shows that they possess unique elements. Evidence from Study 2 suggests that the three narrative-types serve as the building blocks for communication with external stakeholders.Originality/value– These findings contribute to three studies that formed the basis of the study – social entrepreneurship, entrepreneurial resource acquisition and organizational narrative theory – and have implications for work on competing organizational logics. They also produce several practical implications for social entrepreneurs.
The art of entrepreneurial market creation
Authors: Lehman Kim , Ronald Fillis Ian , Miles Morgan 
Published: November 2014

Purpose
– The purpose of this paper is to use the case of the Museum of Old and New Art (MONA) in Hobart, Tasmania, to investigate the role of entrepreneurial marketing (EM) in shaping an arts enterprise. It draws on the notion of effectuation and the process of EM in explaining new venture creation and assesses the part played by David Walsh, the entrepreneurial owner/manager.

Design/methodology/approach
– This case study analysis enables an in-depth appraisal of the impact of EM and effectuation within the growing domain of arts marketing.

Findings
– The paper offers a glimpse into how creativity and business interact in the creation of new markets. It demonstrates how formal methods of marketing are bypassed in the search for owner/manager constructed versions of situational marketing. In addition, it provides insight into dominance of entrepreneur-centrism vs customer-centrism in entrepreneurship marketing. An additional contribution to knowledge is the use of effectuation to assist in better understanding of the role of EM in the market creation process.

Originality/value
– The research carried out here builds on a growing body of work adopting the EM lens to better understand arts marketing and new venture creation.
Data authenticity and data value in policy-driven digital collections
Authors: Bunakov Vasily , Jones Catherine , Matthews Brian , Wilson Michael 
Published: November 2014

Purpose
– The purpose of this paper is to suggest an approach to data value considerations that is related to the generalized notion of authenticity and can be applied to the design of preservation policies. There has been considerable progress in the scalable architectures for policy-driven digital collection preservation as well as in modeling preservation costs. However, modeling the value of both digital artifacts and collections seems a more elusive topic that has yet to find a proper methodology and means of expression.

Design/methodology/approach
– A top-down conceptual analysis was developed and the principles of information technology service management and quality management were applied to the domain of digital preservation. Then, in a bottom-up analysis, the various notions of authenticity in digital preservation projects, reference models and conceptual papers were reviewed.

Findings
– The top-down and bottom-up analyses have a meeting point, establishing a close relation between the concepts of data authenticity and data value.

Originality/value
– The generalized understanding of authenticity can support the design of sensible preservation policies and their application to the formation and long-term maintenance of digital collections.
Expert knowledge elicitation for decision-making in home energy retrofits
Authors: Yaw Addai Duah Daniel , Ford Kevin , Syal Matt 
Published: November 2014

Purpose
– The purpose of this paper is to develop a knowledge elicitation strategy to elicit and compile home energy retrofit knowledge that can be incorporated into the development of an intelligent decision support system to help increase the uptake of home energy retrofits. Major problems accounting for low adoption rates despite well-established benefits are: lack of information or information in unsuitable and usable format for decision making by homeowners. Despite the important role of expert knowledge in developing such systems, its elicitation has been fraught with challenges.

Design/methodology/approach
– Using extensive literature review and a Delphi-dominated data collection technique, the relevant knowledge of 19 industry experts, selected based on previously developed determinants of expert knowledge and suitable for decision making was elicited and compiled. Boolean logic was used to model and represent such knowledge for use as an intelligent decision support system.

Findings
– A combination of comprehensive knowledge elicitor training, Delphi technique, semi-structured interview, and job shadowing is a good elicitation strategy. It encourages experts to describe their knowledge in a natural way, relate to specific problems, and reduces bias. Relevant and consensus-based expert knowledge can be incorporated into the development of an intelligent decision support system.

Research limitations/implications
– The consensus-based and relevant expert knowledge can assist homeowners with decision making and industry practitioners and academia with corroboration and enhancement of existing knowledge. The strategy contributes to solving the knowledge elicitation challenge.

Originality/value
– No previous study regarding a knowledge elicitation strategy for developing an intelligent decision support system for the energy retrofit industry exists.
An experimental study of moisture buffering of bio-insulations in lofts
Authors: Tucker Simon , Latif Eshrar , C. Wijeyesekera Devapriya 
Published: November 2014

Purpose
– The purpose of this paper is to describe and discuss initial work to assess the moisture buffering performance of selected bio-insulations in lofts that suffer from excessive moisture following refurbishment.

Design/methodology/approach
– These conditions were then reproduced in a physical lab-based experiment such that the comparative performance of the bio-insulations and stone wool could be measured.

Findings
– It was found that the bio-insulations could remove over 60 per cent of the moisture in the loft air, and therefore reduce the risk of condensation and its severity.

Research limitations/implications
– The initial work reported here is indicative of the buffering potential of bio-insulations but further work is required to better quantify this performance. There is a need to further examine lofts with moisture problems and to produce reliable testing methods and protocols to be used when retrofitting loft insulation.

Practical implications
– Installers and specifiers of loft insulation should ensure that insulation is installed correctly, as with the drive to increase loft insulation levels the risks of damaging the building fabric through condensation are increasing.

Social implications
– Excessive moisture can damage the building fabric and create health problems. Using insulations that perform well across a range of performance criteria tend to favour bio-insulations, which have a far less harmful impact on the environment than do typical fossil-fuel based insulations.

Originality/value
– The paper presents preliminary findings that support arguments for specifying bio-insulations.
Introduction
Authors: DARLOW MARK , LAFOUGE MARION 
Published: November 2014

AbstractClair‐obscur offers a rich case‐study for the use of metaphor in eighteenth‐century France. Far from being a neutral translation from the Italian chiaroscuro, the appearance of the term is intimately linked to the Querelle du coloris, whose stakes are specifically French. Its propagation at the turn of the eighteenth century may explain why it was exported away from the fine arts towards figurative meanings, often bearing its originally polemical dimension and illustrating a shift in aesthetic perception and reception. This volume aims to provide some evidence for this hypothesis in fields such as drama, music and dance, philosophy and fiction.
‘L'intelligence des Lumières’: On Clair‐Obscur as a Case Study for Early Modern Metaphor
Authors: DARLOW MARK 
Published: November 2014

AbstractThis article considers clair‐obscur within recent thinking on metaphor, considering a range of eighteenth‐century discussions from musical theatre that are irreducible to paraphrase. In the context of the breakdown of ‘imitationist’ theories of the arts in eighteenth‐century France, increasingly viewed as having specificities in terms of medium and the psychology of perception, theatre increasingly adopts visual analogy, so that, as the fields of discussion become more specialised, it allows for terminological and conceptual specificities that can be borrowed in meaningful ways. Yet because these uses are irreducible to paraphrase, they require individual analysis, as shown by a few case studies.
Libertine Clairs‐Obscurs: The Enticement of the Shadows
Authors: GANOFSKY MARINE 
Published: November 2014

AbstractThis article draws an analogy between the early modern definitions of clair‐obscur and eighteenth‐century French libertine literature. In libertine prose the concept of clair‐obscur is used not only to describe voluptuous settings: it also helps authors define libertine writing as always fully conscious of the balance it must reach, for the sake of erotic and aesthetic gratification, between being too clear – and therefore crude – and being too obscure – and therefore unintelligible. However, whereas tradition had conceived shadows as peripheral within representation, libertines conceptualise darkness as an endless source of imaginative liberty and fantasies, making shadows crucial to their pleasure.
A Party Contagion: Party Politics and the Inoculation Controversy in the British Atlantic World, c.1721‐1723
Authors: Parrish David 
Published: November 2014

AbstractHistorians have long been interested in explaining the introduction of inoculation in Britain and its colonies, and numerous studies have sought to explain the success and eventual adoption of the controversial medical practice. These historians have concerned themselves primarily with explanations of the discovery, development and acceptance of the medical procedure. This article takes a different approach, exploring the relationship between the ‘rage of party’, anti‐Jacobitism, the press and debates about smallpox inoculation in Britain in the 1720s and argues that debates about inoculation were integrated into a highly divisive political culture and understood in terms of contested party discourse.
The Effect of Fat Emulsion on Hemodynamics Following Treatment With Propranolol and Clonidine in Anesthetized Rats
Authors: Macala Kimberly , Tabrizchi Reza 
Published: November 2014

AbstractObjectivesThere is evidence indicating that intravenous fatty emulsion (IFE) is beneficial in restoring circulatory function in certain types of drug overdose. The authors investigated the hemodynamic effects of IFE compared to epinephrine in rats treated with propranolol and clonidine.MethodsAnesthetized male Sprague‐Dawley rats were instrumented for measurement of hemodynamics. Rats were randomly assigned to one of six groups (n = 6–8), and each received a clonidine infusion (150 μg/kg) or an equivalent volume of normal saline (0.9% NaCl) over 1 hour. Each rat then received normal saline (1.0 mL/kg) or propranolol (15 to 20 mg/kg). Thereafter, each rat received a dose of IFE (20% solution; 1.0 mL/kg) or epinephrine (2.0 μg/kg) or an equivalent volume of normal saline (1.0 mL/kg).ResultsPropranolol alone or with clonidine significantly (p < 0.05) reduced a number of hemodynamic parameters (mean arterial pressure, 37% to 70%; heart rate, 30% to 51%; cardiac contractility [dP/dtmax], 50% to 67%; and abdominal aortic blood flow, 50% to 83%), while increasing PR intervals (65% to 85%) and QTc intervals (26% to 64%). Saline and epinephrine treatment after propranolol and clonidine combined resulted in no survivors in saline and two out of six in epinephrine group. IFE resulted in significant survival (seven out of eight) for 30 minutes in rats treated with propranolol alone, and propranolol combined with clonidine (seven out of eight).ConclusionsThese data demonstrate that IFE is effective for resuscitating rats overdosed on propranolol combined with clonidine. The effect of IFF is unlikely due to a direct positive inotropic or chronotropic action on the myocardium. IFE is also more effective than epinephrine treatment in this paradigm.
Methamphetamine induces a rapid increase of intracellular Ca++ levels in neurons overexpressing GCaMP5
Authors: Yu Seong‐Jin , Wu Kou‐Jen , Bae Eun K. , Hsu Man‐Jung , Richie Christopher T. , Harvey Brandon K. , Wang Yun 
Published: November 2014

AbstractIn this study, methamphetamine (Meth)‐ and glutamate (Glu)‐mediated intracellular Ca++ (Ca++i) signals were examined in real time in primary cortical neurons overexpressing an intracellular Ca++ probe, GCaMP5, by adeno‐associated viral (AAV) serotype 1. Binding of Ca++ to GCaMP increased green fluorescence intensity in cells. Both Meth and Glu induced a rapid increase in Ca++i, which was blocked by MK801, suggesting that Meth enhanced Ca++i through Glu receptor in neurons. The Meth‐mediated Ca++ signal was also blocked by Mg++, low Ca++ or the L‐type Ca++ channel inhibitor nifedipine. The ryanodine receptor inhibitor dantrolene did not alter the initial Ca++ influx but partially reduced the peak of Ca++i. These data suggest that Meth enhanced Ca++ influx through membrane Ca++ channels, which then triggered the release of Ca++ from the endoplasmic reticulum in the cytosol. AAV‐GCaMP5 was also injected to the parietal cortex of adult rats. Administration of Meth enhanced fluorescence in the ipsilateral cortex. Using immunohistochemistry, Meth‐induced green fluorescence was found in the NeuN‐containing cells in the cortex, suggesting that Meth increased Ca++ in neurons in vivo. In conclusion, we have used in vitro and in vivo techniques to demonstrate a rapid increase of Ca++i by Meth in cortical neurons through overexpression of GCaMP5. As Meth induces behavioral responses and neurotoxicity through Ca++i, modulation of Ca++i may be useful to reduce Meth‐related reactions.
Interaction between positive allosteric modulators and trapping blockers of the NMDA receptor channel
Authors: Emnett Christine M , Eisenman Lawrence N , Mohan Jayaram , Taylor Amanda A , Doherty James J , Paul Steven M , Zorumski Charles F , Mennerick Steven 
Published: November 2014

Background and PurposeMemantine and ketamine are clinically used, open‐channel blockers of NMDA receptors exhibiting remarkable pharmacodynamic similarities despite strikingly different clinical profiles. Although NMDA channel gating constitutes an important difference between memantine and ketamine, it is unclear how positive allosteric modulators (PAMs) might affect the pharmacodynamics of these NMDA blockers.Experimental ApproachWe used two different PAMs: SGE‐201, an analogue of an endogenous oxysterol, 24S‐hydroxycholesterol, along with pregnenolone sulphate (PS), to test on memantine and ketamine responses in single cells (oocytes and cultured neurons) and networks (hippocampal slices), using standard electrophysiological techniques.Key ResultsSGE‐201 and PS had no effect on steady‐state block or voltage dependence of a channel blocker. However, both PAMs increased the actions of memantine and ketamine on phasic excitatory post‐synaptic currents, but neither revealed underlying pharmacodynamic differences. SGE‐201 accelerated the re‐equilibration of blockers during voltage jumps. SGE‐201 also unmasked differences among the blockers in neuronal networks – measured either by suppression of activity in multi‐electrode arrays or by neuroprotection against a mild excitotoxic insult. Either potentiating NMDA receptors while maintaining the basal activity level or increasing activity/depolarization without potentiating NMDA receptor function is sufficient to expose pharmacodynamic blocker differences in suppressing network function and in neuroprotection.Conclusions and ImplicationsPositive modulation revealed no pharmacodynamic differences between NMDA receptor blockers at a constant voltage, but did expose differences during spontaneous network activity. Endogenous modulator tone of NMDA receptors in different brain regions may underlie differences in the effects of NMDA receptor blockers on behaviour.
Multiple myeloma after kidney transplantation
Authors: Safadi Sami , Dispenzieri Angela , Amer Hatem , Gertz Morie A. , Rajkumar S. Vincent , Hayman Suzanne R. , Lacy Martha Q. , Leung Nelson 
Published: November 2014

AbstractBackgroundData regarding multiple myeloma (MM) that develops after kidney transplantation (KTx) are scarce. The outcomes of these patients were evaluated in a retrospective study.MethodsPatients with newly diagnosed MM after KTx were selected. Patients with a diagnosis of MM or those who received treatment for monoclonal gammopathy of renal significance (MGRS) prior to KTx were excluded.ResultsBetween 2001 and 2012, seven patients developed MM after KTx. Reasons for ESRD included ADPKD (1), C1q nephropathy (1), MPGN (2), hypertensive nephrosclerosis (2), and chronic interstitial nephritis (1). Before KTx, only four patients had monoclonal protein studies, four had monoclonal gammopathy of undermined significance (MGUS), and two of them had clonal plasma cells in bone marrow. Median follow‐up after MM was 70 months (range 19–100). Median survival was 80 months. Median time from KTx to MM was 72 months (range 3–204 months). The Kidney allograft failed in four patients due to monoclonal protein‐related renal disease. Five patients received chemotherapy: bortezomib (n = 3), lenalidomide (n = 2), melphalan (n = 1), thalidomide (n = 1), pomalidomide (n = 1), and high‐dose dexamethasone (n = 1). Three patients received ASCT.ConclusionMultiple myeloma after KTx is rare. Most patients who develop MM had MGUS prior to KTx. There is significant renal involvement in these patients. Survival is not worse when compared to MM without KTx. Further work is needed to identify the best treatment options for these patients.
The contribution of imaging in the diagnosis and treatment of axial spondyloarthritis
Authors: Baraliakos Xenofon 
Published: November 2014

AbstractBackgroundThe concept of axial Spondyloarthritis (axSpA) includes patients with non‐radiographic axSpA and ankylosing spondylitis (AS). Inflammatory and chronic/structural changes of the sacroiliac joints and the spine are pathognomonic in patients who are diagnosed with axSpA.Materials and MethodsIn the last years, the evaluation of the natural course of axSpA has been in the focus of research, especially with respect to the relationship between inflammation or postinflammatory changes [detected by magnetic resonance imaging (MRI)] and bone formation (detected by conventional radiographs).ResultsBased on the analysis of spinal MRI data, development of new syndesmophytes is directly associated with the parallel occurrence of inflammatory and postinflammatory (fatty) changes in the edges of the vertebral bodies. In contrast, vertebral edges that show only inflammation but no transformation into fatty lesions show a decreased relative risk for development of new bone formation over time. An inhibitory effect on radiographic progression had not been demonstrated during the first 2 years of continuous anti‐TNFa treatment, however, very recently first studies reported a decreased rate of radiographic progression when patients were continuously treated with TNFa‐blockers for a time period of ≥4 years.ConclusionsThese data are crucial in the understanding of the long‐term clinical course of patients with axSpAin daily practice. According to these results, it becomes obvious that anti‐inflammatory treatment, especially by using tumor‐necrosis‐factor alpha (TNFa)‐blockers, has the best effect on the radiographic outcomes when it is started in anearly disease stage, where only inflammation is driving the disease activity and where structural, postinflammatory changes have not yet occurred.
A White Paper on the medical and social needs of people with epilepsy and intellectual disability: The Task Force on Intellectual Disabilities and Epilepsy of the International League Against Epilepsy
Authors: Kerr Mike , Linehan Christine , Thompson Rose , Mula Marco , Gil‐Nagal Antonio , Zuberi Sameer M. , Glynn Mike 
Published: November 2014

SummaryThis White Paper builds on the publication of the International League Against Epilepsy (ILAE)and International Bureau for Epilepsy (IBE)report “Listening for a change—medical and social needs of people with intellectual disability who have epilepsy” (Listening for a change the medical and social needs of people with epilepsy and intellectual disability, ILAE, 2013). The Paper presents an overview of the recommendations of the report, which aim to improve the health and social care of this important population of people with epilepsy worldwide. Actions in four domains are indicated: (1) the development of standards and initiatives that would enhance diagnosis, pathways to investigation, and treatment; (2) the development of guidelines for treatment, specifically best practice in the management of antiepileptic drugs including rescue medication; (3) the development of standards for primary care, multidisciplinary teamwork, and clinical consultations, with emphasis on the need to enhance communication and improve access to information; and (4) the enhancement of links among different stakeholders including medical services, educational establishments, employment services, organizations providing opportunities for social engagement, and family members. The breadth of needs of this population is a challenge to the epilepsy world, spanning all the professional groupings, care providers, and the research modalities in epilepsy.
Conceptualizing acts and behaviours that comprise intimate partner violence: a concept map
Authors: O'Campo Patricia , Smylie Janet , Minh Anita , Omand Mairi , Cyriac Ajitha 
Published: November 2014

AbstractBackgroundThis study aims to explore the conceptualization of intimate partner violence (IPV) among men and women from diverse subpopulations in Toronto, ON, Canada. Relatively few research efforts have been made to examine differences in conceptualizations of IPV across populations of different race and ethnic backgrounds.MethodsUsing concept mapping methodology, we sampled 67 women and men identified concepts and groups of concepts (domains) that reflected their understandings of the behaviours and attitudes that comprised IPV. We also determined the relative importance of each concept and domain as a contributor to IPV.Results‘External and Cultural Influences’, ‘Victim Response to Abuse’ and ‘Social and Emotional Manipulation’ were a few domains that participants rated as moderately or highly important contributors to IPV. These conceptual domains are often left out of commonly used IPV measures.ConclusionsOur findings have important implications for the conceptualization of IPV and for future IPV measurement and measurement tool development.