bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assisted coiling of saccular wide-necked unruptured intracranial aneurysms: stent versus balloon
Authors: Consoli Arturo , Vignoli Chiara , Renieri Leonardo , Rosi Andrea , Chiarotti Ivano , Nappini Sergio , Limbucci Nicola , Mangiafico Salvatore 
Published: November 2014

Background and purposeAssisted coiling with stents or balloons enables a higher percentage of complete occlusions of saccular unruptured intracranial aneurysms to be achieved with a reasonable complication rate. The aim of this study was to compare stent-assisted coiling and the balloon remodeling technique in terms of efficacy, stability, and safety for the treatment of comparable unruptured saccular intracranial aneurysms.Materials and methods268 patients with 286 saccular unruptured wide-necked intracranial aneurysms were treated at our institution with stent- or balloon-assisted coiling and retrospectively reviewed. Statistical analysis was performed to assess significant differences between the two groups.ResultsThe rate of complete occlusion at the end of the procedure was higher with stent-assisted coiling than with balloon-assisted coiling (86.8% vs 78%) and the same results were also observed after 6 months (92.1% vs 77.6%; p=0.05). About 50% of major recurrences occurred in large to giant aneurysms (p<0.001). The overall complication rate was similar in the stent-assisted and balloon-assisted groups (10.3% vs 9.3%). Independently of the technique, a higher complication rate was observed with bifurcational aneurysms, particularly in the middle cerebral artery (p=0.016).ConclusionsStent-assisted coiling achieved better results in terms of complete occlusion and stability than balloon-assisted coiling with a lower rate of recurrence without being associated with a higher risk of intraprocedural complications. Bifurcational and large to giant aneurysms were associated with higher complication rates and higher recurrence rates, respectively, and still represent a challenge for both techniques.
Remission of neurovascular conflicts in the cerebellopontine angle in interventional neuroradiology
Authors: Li Chuanhui , Li Youxiang , Jiang Chuhan , Wu Zhongxue , Wang Yang , Yang Xinjian 
Published: November 2014

Background and purposeTo investigate the efficacy of endovascular treatment (EVT) for neurovascular conflicts (NVCs) in the cerebellopontine angle (CPA) caused by intracranial aneurysms (IAs) and intracranial arteriovenous malformations (AVMs), including trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia.Materials and methodsFrom January 2010 to January 2014, 14 consecutive patients presenting with three NVCs caused by IAs or intracranial AVMs were admitted to our department. The clinical outcomes of these NVCs after EVT were retrospectively analyzed.ResultsFor four patients with IAs, angiographic follow-up confirmed total occlusion of the lesion in all, and the clinical outcomes of NVC were as follows: gradual relief in two (50%), transient partial relief but recurrence in one (25%), and no palliative effect in one (25%). For the 10 patients with intracranial AVMs, one (10%) experienced transient relief of NVC after angiogram examination (no EVT was performed). Of the other nine patients who received EVT, angiographic follow-up was obtained in seven (70%), demonstrating total obliteration of the lesion in three (30%), subtotal obliteration in two (20%), and partial obliteration in two (20%). Clinical outcomes included immediate relief of NVCs after single EVT in two cases (20%), gradual relief after single EVT in five (50%, one of them experienced transient aggravation), and complete relief after two sessions of EVT in two (20%). Complications of transient cranial nerve paresis related to EVT occurred in two cases (20%) with intracranial AVMs. In all, complete lasting relief of the NVCs was obtained finally in 11 cases (78.6%).ConclusionsEVT is a feasible and less invasive approach for relief of NVCs in the CPA caused by IA or intracranial AVM and could be considered as a therapeutic option in these situations.
Republished: The association between inflammatory markers, serum lipids and the risk of cardiovascular events in patients with rheumatoid arthritis
Authors: Zhang Jie , Chen Lang , Delzell Elizabeth , Muntner Paul , Hillegass William B , Safford Monika M , Millan Iris Yolanda Navarro , Crowson Cynthia S , Curtis Jeffrey R 
Published: November 2014

Abstract

Objective
To examine the association of serum inflammatory markers (erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)) and serum lipid measures (low-density lipoprotein (LDL)- and high-density lipoprotein (HDL)-cholesterol) with risk of myocardial infarction (MI) and ischaemic stroke (IS) among rheumatoid arthritis (RA) patients.

Methods
We conducted a retrospective cohort study using 2005–2010 data from a US commercial health plan. Eligible patients had two or more physician diagnoses of RA during a baseline period of at least 180 days with continuous medical and pharmacy coverage. We computed age-adjusted incidence rates of MI and IS, and used spline regression to assess non-linear associations and Cox-regression to quantify the independent association between the laboratory values and the outcomes.

Results
We identified 44 418 eligible RA patients (mean age 49 years; 76% women). CRP&gt;10 mg/L compared with &lt;1 mg/L was associated with increased MI risk (HR 2.12; 95% CI 1.02 to 4.38). ESR&gt;42 mm/h compared with &lt;14 mm/h was associated with increased risk of MI (HR 2.53; 95% CI 1.48 to 4.31) and IS (HR 2.51; 95% CI 1.33 to 4.75) risk. HDL-cholesterol ≥60 mg/dL (1.6 mmol/L) compared with &lt;40 mg/dL (1.0 mmol/L) was associated with reduced MI risk (HR 0.37; 0.21 to 0.66). The association between LDL and MI was not linear; the lowest risk was observed among patients with LDL between 70 mg/L (1.8 mmol/L) and 100 mg/L (2.6 mmol/L). We did not observe a significant association between LDL and IS.

Conclusions
This study provides evidence supporting the hypothesis that RA-related systemic inflammation plays a role in determining cardiovascular risk and a complex relationship between LDL and cardiovascular risk.
Republished: Cardiac MRI of patients with implanted electrical cardiac devices
Authors: Ainslie Mark , Miller Christopher , Brown Benjamin , Schmitt Matthias , Davidson Neil , Fox David J 
Published: November 2014

Abstract
Implantable pulse generators and defibrillators have traditionally been considered contraindications to MRI. However, recent data have challenged this paradigm and demonstrated that patients with newer generation devices can safely undergo MRI, including cardiac MRI, provided basic precautions are taken. Indeed, the introduction of MRI conditional systems has led to a conceptual shift in clinical decision making—‘can this patient undergo MRI safely?’ is being superseded by ‘should this patient be implanted with an MRI conditional device?’. This review outlines the risks associated with MRI in patients with implanted cardiac devices, and discusses practical measures to minimise risks and facilitate safe and diagnostic scanning.
Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP)
Authors: Subramaniam Saravanan , Thielmann Ina , Morowski Martina , Pragst Ingo , Sandset Per Morten , Nieswandt Bernhard , Etscheid Michael , Kanse Sandip M. 
Published: November 2014

SummaryFactor VII (FVII) activating protease (FSAP) is a circulating protease with a putative function in blood coagulation and fibrinolysis. Genetic epidemiological studies have implied a role for FSAP in carotid stenosis, stroke and thrombosis. To date, no in vivo evidence is available to support these claims. We have, for the first time, used FSAP-/- mice to define its role in thrombosis and haemostasis in vivo and to characterise the molecular mechanisms involved. FeCl3–induced arterial thrombosis in carotid and mesenteric artery revealed that the occlusion time was significantly increased in FSAP-/- mice (p< 0.01) and that some FSAP-/- mice did not occlude at all. FSAP-/- mice were protected from lethal pulmonary thromboembolism induced by collagen/ epinephrine infusion (p< 0.01). Although no spontaneous bleeding was evident, in the tail bleeding assay a re-bleeding pattern was observed in FSAP-/- mice. To explain these observations at a mechanistic level we then determined how haemostasis factors and putative FSAP substrates were altered in FSAP-/- mice. Tissue factor pathway inhibitor (TFPI) levels were higher in FSAP-/- mice compared to WT mice whereas FVIIa levels were unchanged. Other coagulation factors as well as markers of platelet activation and function revealed no significant differences between WT and FSAP-/- mice. This phenotype of FSAP-/- mice could be reversed by application of exogenous FSAP. In conclusion, a lack of endogenous FSAP impaired the formation of stable, occlusive thrombi in mice. The underlying in vivo effect of FSAP is more likely to be related to the modulation of TFPI rather than FVIIa.
Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency
Authors: Asselta Rosanna , Platè Manuela , Robusto Michela , Borhany Munira , Guella Ilaria , Soldà Giulia , Afrasiabi Abdolreza , Menegatti Marzia , Tahir Shamsi , Peyvandi Flora , Duga Stefano 
Published: November 2014

SummaryFibrinogen is a plasma glycoprotein mainly synthesised by hepatocytes and circulating as a 340-kDa hexamer consisting of two sets of three different polypeptide chains (Aα, Bβ, and γ, encoded by the FGA, FGB, and FGG gene, respectively). Congenital afibrinogenaemia and hypofibrinogenaemia are rare bleeding disorders characterised by abnormally low levels of functional and immunoreactive fibrinogen in plasma, associated with haemorrhagic manifestations of variable severity. While afibrinogenaemia is caused by mutations in the homozygous or compound heterozygous state in one of the three fibrinogen genes, hypofibrinogenaemia is generally due to heterozygous mutations, and is usually characterised by a milder phenotype. The mutational spectrum of these quantitative fibrinogen disorders includes large deletions, point mutations causing premature termination codons, and missense mutations often affecting fibrinogen assembly and/or secretion. Here we report the clinical and molecular characterisation of 13 unrelated afibrinogenaemic and eight hypofibrino - genaemic patients, leading to the identification of 17 different mutations (10 hitherto unknown). All the newly-identified missense and splicing mutations were in vitro expressed to verify their pathogenic role. Our data increase the number of mutations causing quantitative fibrinogen deficiencies by about 7 %. The high number of private mutations identified in the analysed probands indicates that the full mutational screening of the three fibrinogen genes is still required for molecular diagnosis.
Impact of variables of the P-selectin – P-selectin glycoprotein ligand-1 axis on leukocyte-platelet interactions in cardiovascular disease
Authors: Koppensteiner Renate , Kaider Alexandra , Eichelberger Beate , Mannhalter Christine , Panzer Simon , Gremmel Thomas 
Published: November 2014

SummaryThe formation of leukocyte-platelet aggregates (LPA), through the P-selectin – P-selectin glycoprotein ligand (PSGL)-1 axis, plays a pivotal role in atherothrombosis. In order to investigate the influence of platelet (pP-selectin) and soluble P-selectin (sP-selectin), and of variations in the genes encoding for P-selectin (SELP) and PSGL-1 (SELPLG) on LPA formation, we assessed monocyte (MPA)- and neutrophil-platelet aggregates (NPA) as well as pP-selectin by flow cytometry in 263 patients undergoing angioplasty and stenting. sP-selectin was determined by ELISA, the SELP Pro715 allele and the SELPLG Ile62 allele were determined by allele specific PCR. The Pro715 allele was significantly associated with lower levels of in vivo pP-selectin and sP-selectin, while agonists´ inducible pP-selectin was not influenced by the Pro715 allele. PP-selectin was significantly associated with MPA and NPA formation. The in vivo formation of MPA and NPA depended to 19 % and 7.4 %, respectively, on in vivo pP-selectin, irrespective of the Pro715 allele and the Ile62 allele carrier status. TRAP-6 inducible MPA and NPA depended to 34 % and 27 %, respectively, on TRAP-6 inducible pP-selectin, but were independent of the Pro715 allele carrier status. Carriers of the Ile62 allele showed a stronger correlation between TRAP-6 inducible pP-selectin and TRAP-6 inducible MPA/NPA than non-carriers. Furthermore, TRAP-6 inducible NPA were higher in Ile62 allele carriers, which suggests higher thrombin sensitivity. In conclusion, our findings point to the significant role of pP-selectin for MPA and NPA formation, while other variables like sP-selectin, the SELP Pro715 allele and the SELPLG Ile62 allele have less influence.
O promowaniu dialektu wielkopolskiego w Internecie. Raport z badań
Authors: Cemborowski Bartosz 
Published: November 2014

Promoting the Wielkopolska dialect on the Internet. Research reportThe aim of this article is to show the forms of promotion and distribution of the Wielkopolska dialect on the Internet. The sources that were used in this study are interviews with respondents residing the międzychodzki district, a survey conducted among young people speaking this dialect and the most popular Internet forms, which affect the behavior of the dialect in the language of the younger generation of users. The article describes: Internet memes, a social networks fanpage, dictionary entries in an electronic form, blogs, music promoted by websites, clothing, and everyday objects that are distributed on auction sites - the author takes into account the use of these forms in order to promote and disseminate the Wielkopolska dialect. O promowaniu dialektu wielkopolskiego w Internecie. Raport z badańCelem tego artykułu jest wskazanie sposobów promocji i dystrybucji dialektu wielkopolskiego w Internecie. Materiały użyte w tym studium pochodzą z wywiadów z informatorami zamieszkującymi w okolicach Międzychodu, ankiety przeprowadzonej wśród młodych osób używających dialektu oraz obserwacji najpopularniejszych form internetowych, które mają wpływ na zachowanie dialektu w języku młodego pokolenia użytkowników. W artykule opisano: internetowe memy, fanpage’e na portalach społecznościowych, ilustracje z hasłami słowniko­wymi, blogi, muzykę promowaną w sieci, ubrania i przedmioty codziennego użytku rozprowadzane na internetowych aukcjach. Autor bierze pod uwagę użycie tych form w celu promocji i upowszechniania dialektu wielkopolskiego.
Popfeminizm w służbie rewolucji. Ruchy kobiece i praktyki protestu na przykładzie ukraińskiej grupy Femen
Authors: Szymańska Justyna Anna 
Published: November 2014

Pop feminism in the service of revolution. Women’s movements and practices of protest: Ukrainian group Femen case studyIn my paper I take a close look at the protest group, Femen, the circumstances of its creation, development and recent activities - initially in Ukraine, latterly also in Western Europe. I analyse the character of the group which belongs to the category of new social movements, and I present and analyse those indications of the activity of demonstrations of the movement based on what took place at street level. The object of my interest is also the issue of the appearance of the representatives of Femen in the media (new and traditional) and the influence of the pop culture on different aspects of its activity. I also question the issue of the employment of nudity in the public domain, and its connection with the usage of the expression of nationality against the background of other feminist movements. Popfeminizm w służbie rewolucji. Ruchy kobiece i praktyki protestu na przykładzie ukraińskiej grupy FemenW pracy pochylam się nad ukraińskim ruchem protestu Femen, kontekstem jego powstania, rozwoju i działalności – początkowo w Ukrainie, a potem także w Europie Zachodniej. Analizuję charakter grupy jako należącej do kategorii nowych ruchów społecznych, a także przedstawiam i analizuję przejawy działań kontestacyjnych ruchu, opartych o konwencję performance’u i przedstawień ulicznych. Przedmiotem mojego zastanowienia jest także kwestia obecności oraz funkcjonowania przedstawicielek Femenu w mediach (nowych oraz tradycyjnych) oraz wpływów popkultury na różne przejawy jego aktywności. Rozważam także kwestię wykorzystania nagości w sferze publicznej, powiązaną z użyciem idiomu narodowościowego, w kontekście innych ruchów feministycznych.
Традыцыйныя формы звароту да субяседніка ў беларускай мове
Authors: Kaptsiuh Iryna 
Published: November 2014

Traditional forms of addressing an interlocutor in the Belarusian languageThe article examines the traditional forms of addressing an interlocutor in the Belarusian language. It focuses on the use of anthroponyms when addressing someone, the use of phrases with suffixes of subjective evaluation and the use of vocative and clipped noun forms functioning when addressing an interlocutor. The conclusion put forward is that there is a national specificity in the use of this form of addressing an interlocutor in the Belarusian language. Tradycyjne formy zwracania się do interlokutora w języku białoruskimW artykule analizowane są tradycyjne formy zwracania się do interlokutora w języku białoruskim. Artykuł skupia się na używanych w tej funkcji antroponimach, wyrażeniach z przyrostkami oceny subiektywnej, krótkich formach i wołaczu rzeczowników. Z analizy wynika, że istnieje pewna specyfika narodowa posługiwania się tymi formami zwracania się do rozmówcy w języku białoruskim.
Polskie miejsca pamięci w północnej Bośni
Authors: Wichniewicz Paulina Anna 
Published: November 2014

Polish realms of memory in northern BosniaThis article presents the transformation in Bosnia and Herzegovina which began after the war during the years 1991-1995. The most important objective was the liberation and emancipation of the forgotten memory of minorities. These processes are also expressed in relation to the Polish minority which came into existence in the territories of Bosnia and Herzegovina in the late nineteenth and early twentieth century with the government takeover by Austria-Hungary and the announcement of the program of colonization. The changes described were significantly apparent in the reconstruction of Polish realms of memory: Polish shrines in Celinovac, Polish church in Cerovljani, Polish cemeteries: in Devetina and Novi Martinac and also in the Yugoslav-Polish partisan cemetery in Srbac. Of interest, the ‘time of memory’ which took place involved all social actors: the government of the Republic of Srpska and the municipalities of Srbac and Nowogrodziec, the Embassy of the Polish Republic in Sarajevo, representatives of local communities - Serbs and the Polish minority from Ćelinovac. Polskie miejsca pamięci w północnej BośniArtykuł prezentuje przemiany, które od czasu zakończenia wojny 1991–1995 roku dokonują się w granicach Bośni i Hercegowiny. Ich głównym celem jest wyzwalanie i emancypacja pamięci zapomnianych mniejszości narodowych. Procesy te dotyczą również polskiej mniejszości narodowej, która na terytorium Bośni i Hercegowiny pojawiła się pod koniec XIX i na początku XX wieku wraz z przejęciem administracji przez Austro-Węgry oraz ogłoszeniem programowej kolonizacji. Najsilniej ujawniają się w rekonstruowaniu polskich miejsc pamięci: polskiej kapliczki w Ćelinovacu, polskiego kościoła w Cerovljanach, cmentarzy polskich w Devetinie i Nowym Martyńcu oraz partyzanckiego jugosłowiańsko-polskiego w Srbacu. Co ciekawe, „czas pamięci“, który nastał, odcisnął swe piętno na działalności wszystkich aktorów społecznych: władz Republiki Serbskiej oraz gminnych, w tym wypadku gmin Srbac oraz Nowogrodziec, Ambasady Rzeczypospolitej w Sarajewie, przedstawicieli społeczności lokalnych – Serbów oraz polskiej mniejszości narodowej z Ćelinovaca.
Stematografija Hristofora Žefarovicia jako dokument kulturowych i narodowych dążeń Serbów w pierwszej połowie XVIII wieku
Authors: Romanowska Justyna 
Published: November 2014

Hristofor Zhefarovich’s Stemmatographia as a document of the cultural and national aspirations of the Serbs in the first half of the eighteenth centuryStemmatographia, by Hristofor Zhefarovich (1741), was one of the most important Serbian books published in the first half of the 18th century. The first part contains the majestic portraits of the canonized Serbian sovereigns who built and strengthened the medieval Serbian state; the second part presents images of the coats of arms of the Balkan lands. Work composed in such a way corresponded to the political and religious program of the Archbishopric of Karlovci, the most important Serbian religious and secular institution in the lands belonging to the Habsburg monarchy. The reference to the tradition of the medieval state by presenting images of rulers and marking its territories by coats of arms legitimized the authority of the Serbian Orthodox Church that declared itself to be the heir and continuator of this tradition. At the same time, the gallery of portraits of the rulers and Orthodox Church notables constituted the national pantheon of saints that conferred a sacral aspect on Serbian history. Stematografija Hristofora Žefarovicia jako dokument kulturowych i narodowych dążeń Serbów w pierwszej połowie XVIII wiekuStematografija Hristofora Žefarovicia (1741) była jedną z najważniejszych serbskich książek wydanych w pierwszej połowie XVIII wieku. Pierwsza jej część zawiera majestatyczne portrety kanonizowanych serbskich władców, którzy budowali i umacniali średniowieczne państwo serbskie; druga przedstawia wizerunki herbów ziem bałkańskich. Tak skomponowanie dzieło wpisywało się w polityczno-religijny program Metropolii Karłowickiej, najważniejszej serbskiej instytucji religijnej i świeckiej na ziemiach należących do monarchii habsburskiej. Odwołanie się do tradycji średniowiecznego państwa poprzez zaprezentowanie wizerunków władców oraz określenie jego terytoriów poprzez umieszczenie herbów legitymizowało władzę serbskiej Cerkwi uznającej się za spadkobierczynię i kontynuatorkę tej tradycji. Jednocześnie galeria portretów władców i dostojników cerkiewnych konstytuowała narodowy panteon świętych, który nadawał historii Serbii wymiar sakralny.
Physical activity on medical prescription: A qualitative study of factors influencing take-up and adherence in chronically ill patients
Authors: Gasparini William , Knobé Sandrine , Didierjean Romaine 
Published: November 2014

Objective: This study sought to determine the effects of an innovative public health programme offering physical and sports activities on medical prescription to chronically ill patients. Method: Semi-structured interviews were conducted with programme participants at two time points: at the start of their activity ( n = 33) and 3 months after the first interview ( n = 25). Results: Findings reveal that this public health initiative engaged a very sedentary population taking starting or returning to physical exercise. Participants reported beneficial effects on their well-being and underlined the benefits of being monitoring and participating in activities with other patients. Conclusion: For individuals interviewed, starting (or getting back to) a physical activity proved beneficial, and their evaluation of the programme shows that it matched their expectations, although study participants also expressed difficulty in shifting to physical activity independently of the programme.