bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interictal intracranial EEG asymmetry lateralizes temporal lobe epilepsy
Authors: Conrad Erin C , Lucas Alfredo , Ojemann William K S , Aguila Carlos A , Mojena Marissa , LaRocque Joshua J , Pattnaik Akash R , Gallagher Ryan , Greenblatt Adam , Tranquille Ashley , Parashos Alexandra , Gleichgerrcht Ezequiel , Bonilha Leonardo , Litt Brian , Sinha Saurabh R , Ungar Lyle , Davis Kathryn A 
Published: August 2024

Abstract
Patients with drug-resistant temporal lobe epilepsy often undergo intracranial EEG recording to capture multiple seizures in order to lateralize the seizure onset zone. This process is associated with morbidity and often ends in postoperative seizure recurrence. Abundant interictal (between-seizure) data are captured during this process, but these data currently play a small role in surgical planning. Our objective was to predict the laterality of the seizure onset zone using interictal intracranial EEG data in patients with temporal lobe epilepsy. We performed a retrospective cohort study (single-centre study for model development; two-centre study for model validation). We studied patients with temporal lobe epilepsy undergoing intracranial EEG at the University of Pennsylvania (internal cohort) and the Medical University of South Carolina (external cohort) between 2015 and 2022. We developed a logistic regression model to predict seizure onset zone laterality using several interictal EEG features derived from recent publications. We compared the concordance between the model-predicted seizure onset zone laterality and the side of surgery between patients with good and poor surgical outcomes. Forty-seven patients (30 female; ages 20–69; 20 left-sided, 10 right-sided and 17 bilateral seizure onsets) were analysed for model development and internal validation. Nineteen patients (10 female; ages 23–73; 5 left-sided, 10 right-sided, 4 bilateral) were analysed for external validation. The internal cohort cross-validated area under the curve for a model trained using spike rates was 0.83 for a model predicting left-sided seizure onset and 0.68 for a model predicting right-sided seizure onset. Balanced accuracies in the external cohort were 79.3% and 78.9% for the left- and right-sided predictions, respectively. The predicted concordance between the laterality of the seizure onset zone and the side of surgery was higher in patients with good surgical outcome. We replicated the finding that right temporal lobe epilepsy was harder to distinguish in a separate modality of resting-state functional MRI. In conclusion, interictal EEG signatures are distinct across seizure onset zone lateralities. Left-sided seizure onsets are easier to distinguish than right-sided onsets. A model trained on spike rates accurately identifies patients with left-sided seizure onset zones and predicts surgical outcome. A potential clinical application of these findings could be to either support or oppose a hypothesis of unilateral temporal lobe epilepsy when deciding to pursue surgical resection or ablation as opposed to device implantation.
Computational insights into the molecular dynamics of the binding of ligands in the methanol dehydrogenase
Authors: Lee One-Sun , Lee Sung Haeng 
Published: August 2024

Abstract
Methanol dehydrogenase is a promising biocatalyst for industrial use, converting methanol to formaldehyde. Our molecular modeling revealed methanol binds to methanol dehydrogenase with ∼7 kcal/mol free energy, while formaldehyde binds with ∼4 kcal/mol. This suggests that methanol remains longer in the active site, and formaldehyde exits more readily postreaction. These insights are crucial for designing more efficient methanol dehydrogenase variants for industrial applications.
Reasons for fear of cancer recurrence after endoscopic treatment of T1 esophageal adenocarcinoma. A semi-structured interview study
Authors: Rosmolen Wilda D , Pouw Roos E , Bergman Jacques J , Sprangers Mirjam A G , Nieuwkerk Pythia T 
Published: August 2024

SUMMARY
Prior research has shown that patients with early Barrett’s neoplasia treated endoscopically report at least the same level of fear for cancer recurrence as patients treated surgically for a more advanced disease stage. The aim of this qualitative study was to gain insight into the reasons why endoscopically treated patients fear or not fear cancer recurrence. Patients treated endoscopically for T1 esophageal adenocarcinoma participated in a semi-structured interview. Patients were asked open questions about their fear of cancer recurrence and presented an a priori list of possible reasons for experiencing or not experiencing fear of cancer recurrence. Data saturation was reached with 12 patients who added 7 new reasons. Reasons that induced fear of cancer recurrence were related to physical symptoms, if cancer was diagnosed as an accidental finding and experiences with cancer in close relations. Endoscopic surveillance was mentioned as a reason for not experiencing fear of cancer recurrence. Patients reduced their fear of cancer recurrence by talking to close relations and seeking distraction. Caregivers reduced patients fear of cancer recurrence by giving adequate information and by showing photo of the treatment and the results of the treatment. According to patients with early Barrett’s neoplasia, receiving comprehensible information about the risk of recurrence and potential symptoms that may or may not be indicative of cancer recurrence, and continuing endoscopic surveillance, reduced fear of cancer recurrence. We recommend that healthcare providers discuss fear of cancer recurrence with their patients to enable tailoring information provision to their needs.
Expanding outpatient management of low-risk pulmonary embolism to the pregnant population: a case series
Authors: Vinson David R , Roubinian Nareg H , Pai Ashok P , Sperling Jeffrey D 
Published: August 2024

Abstract

Background
Outpatient treatment of pregnant patients with acute pulmonary embolism (PE) is recommended by some obstetric and haematology societies but has not been described in the literature. Little is known about patient selection and clinical outcomes.

Case summary
We report two cases of pregnant patients diagnosed with acute PE. The first, at 9 weeks of gestational age, presented to the emergency department with 12 h of pleuritic chest pain and was diagnosed with segmental PE. She was normotensive and tachycardic without evidence of right ventricular dysfunction. She received multispecialty evaluation, was deemed suitable for outpatient management, and, after 12 h of monitoring, was discharged home on enoxaparin with close follow-up. The second case, at 30 weeks of gestational age, presented to obstetrics clinic with 3 days of dyspnoea. Vital signs were normal except for tachycardia. She was referred to labour and delivery, where she was diagnosed with segmental PE. Her vital signs were stable, and she had no evidence of right ventricular dysfunction. After 6 h of monitoring, she was discharged home on enoxaparin with close follow-up. Neither patient developed antenatal complications from their PE or its treatment.

Discussion
This case series is the first to our knowledge to describe patient and treatment characteristics of pregnant patients with acute PE cared for as outpatients. We propose a definition for this phenomenon and discuss the benefits of and provisional selection criteria for outpatient PE management, while engaging with professional society guidelines and the literature. This understudied practice warrants further research.
A professional training to make English language instructors AI-ready
Authors: Kaya M Haldun 
Published: August 2024

Abstract
This qualitative case study aims to investigate the impact of a specially designed professional development course on three aspects: English language instructors’ (1) knowledge, (2) skills, and (3) self-efficacy in integrating AI into their teaching. Cognitive apprenticeship and socio-constructivism set the theoretical foundations of this course. Working with 20 instructors at university, the researcher used two data sources (participants’ opinions and their recorded lessons) and four data collection tools (pre-post course interviews, weekly-assigned implementations, their self-reflections on their AI use, and feedback on the course) to evaluate the impact of this course. The data suggest that this AI course for English language instructors likely made a significant difference, enhancing AI integration into teaching. This training could serve as a model for AI-ready instructors, improving their knowledge, skills, and self-efficacy. There are also some data that highlight challenges and limitations, unveiling different aspects of this complex field of study.
Music in a vanished kingdom: medieval polyphony in the Teutonic Order state in Prussia
Authors: Gancarczyk Paweł 
Published: August 2024

Abstract
The state of the Teutonic Order in Prussia, or Ordensstaat (1228–1525), belongs to those ‘vanished kingdoms’ which—devoid of any contemporary heirs—remain on the margins of historical narratives about music. The aim of this article is to describe polyphonic practices in medieval Prussia on the basis of archival and musical sources. Although the information they contain is of a fragmentary character, referring mainly to the first half of the 15th century, it does indicate that a variety of music was cultivated: from simply polyphony in chant notation to international Ars Nova. Outside the major ecclesiastic centres, conditions for the cultivation of polyphony could have existed at the court of the Grand Master, at which musicians—mostly instrumentalists—from across Europe appeared. Particular attention is devoted in the article to fragments from the Gdańsk Library of the Polish Academy of Sciences (Ms. 2153a) which contain works in the style of Central European polyphony, belonging to the genres of motet, cantio and rotulum. These and other sources indicate that the culture of medieval Prussia should be seen from the perspective of various European connections, and not as Germanic or Polish culture, as has often occurred in the past.
Design and implementation of a scalable high-performance computing (HPC) cluster for omics data analysis: achievements, challenges and recommendations in LMICs
Authors: Ghedira Kais , Khamessi Oussema , Hkimi Chaima , Kamoun Selim , Dhamer Nader , Daassi Kamel , Ben Salah Wassim , Othman Houcemeddine , Belhadj Wahbi , Ghorbal Youssef 
Published: August 2024

Abstract

Background
The advent of high-throughput technologies, including cutting-edge sequencing devices, has revolutionized biomedical data generation and processing. Nevertheless, big data applications require novel hardware and software for parallel computing and management to handle the ever-growing data size and analysis complexity. On-premise, high-performance computing (HPC) is increasingly used in biomedical research for big data stewardship.

Findings
In this work, we present Tunisia’s first high-performance computational infrastructure for omics research.

Method
We highlight measurements and recommendations that may help institutions in other low- and middle-income countries that are eager to implement local HPC in facilities for bioinformatics research and omics data analyses.
Singlestick purchases: a comparative cross-country analysis in 10 African countries, Global Adult Tobacco Survey, 2012–21
Authors: Mbulo Lazarous , Blutcher-Nelson Glenda , Chowdhury Pranesh P , Egbe Catherine O , Bouhabib Abdallahi , Palipudi Krishna 
Published: August 2024

Abstract
We utilized Global Adult Tobacco Survey data to examine singlestick purchases and related demographic characteristics in 10 African countries (Botswana, Cameroon, Ethiopia, Kenya, Nigeria, Mauritania, Senegal, South Africa, Uganda and Tanzania). Results show the weighted percentages and prevalence ratios with predicted marginal means to evaluate significant differences between groups (P &lt; 0.05). The prevalence of singlestick purchases among the 10 African countries ranged from 48.4% in South Africa to 92.0% in Tanzania. Across countries, the incidence of singlestick purchases was higher in urban areas than rural areas in Kenya; among those aged 15–24 years versus those aged 45 years and older in Botswana, Ethiopia, Mauritania, Nigeria and South Africa; and among those aged 25–44 years versus those aged 45 years and older in Botswana, South Africa and Tanzania. The incidence in Botswana was higher among adults with no formal or primary education than among those with secondary or higher education. In South Africa, the incidence was higher among adults in the middle or lower wealth index than among those in the high or highest wealth index. The findings suggest opportunities for strengthening efforts to prevent singlestick purchases through effective legislation and enforcement in line with Article 16 of the World Health Organization Framework Convention on Tobacco Control.
CGD: a multi-omics database for Chrysanthemum genomic and biological research
Authors: Ye Jingxuan , Wang Chun , Liu Ye , Chen Shaocong , Jin Jinyu , Zhang Lingling , Liu Peixue , Tang Jing , Zhang Jing , Wang Zhenxing , Jiang Jiafu , Chen Sumei , Chen Fadi , Song Aiping 
Published: August 2024

Abstract
Asteraceae is the largest family of dicotyledons and includes Chrysanthemum and Helianthus, two important genera of ornamental plants. The genus Chrysanthemum consists of more than 30 species and contains many economically important ornamental, medicinal, and industrial plants. To more effectively promote Chrysanthemum research, we constructed the CGD, a Chrysanthemum genome database containing a large amount of data and useful tools. The CGD hosts well-assembled reference genome data for six Chrysanthemum species. These genomic data were fully annotated by comparison with various protein and domain data. Transcriptome data for nine different tissues, five flower developmental stages, and five treatments were subsequently added to the CGD. A fully functional ‘RNA data’ module was designed to provide complete and visual expression profile data. In addition, the CGD also provides many of the latest bioinformatics analysis tools, such as the efficient sgRNA search tool for Chrysanthemum. In conclusion, the CGD provides the latest, richest, and most complete multi-omics resources and powerful tools for Chrysanthemum. Collectively, the CGD will become the central gateway for Chrysanthemum genomics and genetic breeding research and will aid in the study of polyploid evolution.
Construction and optimization of data model based on knowledge feature in transmission line equipment state recognition
Authors: Chen Jiangqi , Zhang Zhisong , Zhang Guoliang , Kong Qingyu , Qiu Shoudong 
Published: August 2024

Abstract
Transmission lines are a vital component of the power system, and their operational status directly affects the safety and stability of the entire grid. This study utilizes the association rules algorithm to conduct an in-depth analysis of the historical data of the lines' status, achieving the mining of knowledge features. Based on this, a key state quantity system is constructed, and a transmission line operational status recognition model is established, combined with the random forest algorithm, and further optimized. Through the selection of association rules and confidence, 8 components and 81 indicator state parameters that can reflect the operational status of transmission lines are determined, quantified into a key parameter system. For the improved model, the accuracy of the evaluation of the four state levels is more than 90%. Through comparative experiments with classical models on the national grid data set, the applicability and rationality of the proposed classification algorithm are verified. The model based on the random forest algorithm is capable of efficiently handling large-scale data sets and high-dimensional features, and resisting overfitting in the classification task of transmission line equipment status recognition, while also effectively managing imbalanced data sets. With an increase in the amount of collected data and improvement in data quality, future research can continue to focus on optimizing the model to improve recognition accuracy.
Land Loss and Labour Control: The Intersection of Land Dispossession and Labour Law in South African History
Authors: van Staden Marthinus 
Published: August 2024

Abstract
This article considers the intricate relationship between labour law and the dispossession of property, with a focus on the profound impact this interplay had on the lives of indigenous South Africans. Central to this discourse is the thesis that the dispossession of land catalysed a transition for indigenous populations from landowners to labourers, a shift that markedly diminished their quality of life. This exploration is contextualised through the lens of the landmark case of Izaacs v Government of the Republic of South Africa and Others, which serves as a contemporary reference point for understanding the enduring effects of historical injustices. The article explores the nature of labour or work prior to colonisation, offering insights into the indigenous socio-economic structures and their transformation post-colonisation. It traces the history of colonisation in South Africa, with a particular emphasis on how the systematic dispossession of land was instrumental in forcing indigenous populations into a new form of labour and servitude. This historical analysis is crucial in understanding the genesis of the socio-economic challenges faced by these communities. Furthermore, the article scrutinises the evolution of labour in the context of this dispossession. It argues that the legal framework surrounding labour, especially the contract of employment, played a pivotal role in perpetuating the subjugation of dispossessed populations. It is shown how the contract of employment, with its inherent element of control, became a tool for entrenching the disadvantaged position of indigenous peoples within the labour market. In its conclusion, the article synthesises these historical and legal analyses to argue that the legacy of land dispossession and the subsequent transformation of labour law have had a lasting and detrimental impact on the lives of indigenous South Africans. This exploration will not only shed light on a significant aspect of South African history but also contributes to the broader understanding of how legal frameworks can both reflect and perpetuate social inequalities.
Ethnicity, Women's Empowerment and Decisions about Children's Education in Ghana
Authors: Dimova Ralitza , Fielding David 
Published: August 2024

Abstract
There is evidence from some low-income countries that women's empowerment is associated with better child health and education outcomes, suggesting that mothers value these outcomes more than fathers do, on average. We hypothesise that this difference will be smaller in matrilineal societies, and using a Ghanaian household survey that includes data on children's education, we find evidence consistent with this distinction between matrilineal and patrilineal cultures. Women's empowerment is higher, on average, in matrilineal households, but this does not explain why their mean educational expenditure is higher, because empowerment in matrilineal households has no significant effect on expenditure. One possible explanation for these findings is cross-cultural heterogeneity in parental preferences: in the matrilineal society, women are more empowered, on average, and more money is spent on children's education, but the first difference is not the cause of the second.
Suburbanization and transportation in European cities
Authors: Garcia-López Miquel-Àngel , Pasidis Ilias , Viladecans-Marsal Elisabet 
Published: August 2024

Abstract
We study whether highway and railroad improvements cause population suburbanization in Europe’s cities. We construct a unique population and transportation dataset covering 579 cities from 29 European countries for the period 1961–2011. In order to make a causal inference, we rely on historical instruments. Our average results indicate that highways, but not railroads, were responsible for the suburbanization process: each additional highway ray decreased the share of the central city population by 5 percentage points, whereas new railroads had no impact. The heterogeneity analyses provide evidence of different patterns based on the time of the investment, the city’s size and density, and its geographical location.
Genomic implications of the repeated shift to self-fertilization across a species’ geographic distribution
Authors: Lucek Kay , Flury Jana M , Willi Yvonne 
Published: August 2024

Abstract
The ability to self-fertilize often varies among closely related hermaphroditic plant species, though, variation can also exist within species. In the North American Arabidopsis lyrata, the shift from self-incompatibility (SI) to selfing established in multiple regions independently, mostly since recent postglacial range expansion. This has made the species an ideal model for the investigation of the genomic basis of the breakdown of SI and its population genetic consequences. By comparing nearby selfing and outcrossing populations across the entire species’ geographic distribution, we investigated variation at the self-incompatibility (S-)locus and across the genome. Furthermore, a diallel crossing experiment on one mixed-mating population was performed to gain insight into the inheritance of mating system variation. We confirmed that the breakdown of SI had evolved in several S-locus backgrounds. The diallel suggested the involvement of biparental contributions with dominance relations. Though, the population-level genome-wide association study did not single out clear-cut candidate genes but several regions with one near the S-locus. On the implication side, selfing as compared to outcrossing populations had less than half of the genomic diversity, while the number and length of runs of homozygosity (ROHs) scaled with the degree of inbreeding. Selfing populations with a history of long expansion had the longest ROHs. The results highlight that mating system shift to selfing, its genetic underpinning and the likely negative genomic consequences for evolutionary potential can be strongly interlinked with past range dynamics.
Derivational morphology and suffixing bias on linguistic and nonlinguistic material
Authors: Polyanskaya Leona , Skopeteas Stavros , Halama Peter , Hollenbach Robin , Ordin Mikhail 
Published: August 2024

Abstract
Across world languages, grammatical meanings tend to be expressed by suffixes. Whether this bias is defined by shaping language so that it is easily processed by domain-general cognitive mechanisms or whether the bias is specific to the language domain has not been resolved. Most evidence supporting these competing hypotheses focuses on the effect of suffixing bias on inflectional morphology and ignores derivational morphology. Here, we explored suffixing bias in German and Slovak populations. These languages are strongly suffixing in terms of inflectional morphology but differ in verbal derivational morphology. Verbal prefixes can be detached from the root in the German language and are always attached to the root in the Slovak language. We explored whether suffixing bias can be observed in both populations while detecting and memorizing linguistic and nonlinguistic sequences in a continuous sensory input by means of statistical learning mechanisms. We found that suffixes facilitate statistical learning more than prefixes on linguistic material, and the effect was not observed on nonlinguistic material, suggesting that suffixing bias is specific to speech. When people are forced to choose between suffixed and prefixed sequences from the familiarization stream, German speakers show a stronger preference for suffixed sequences, while Slovak speakers do not show any preference; hence, properties of derivational morphology of the ambient language can modulate suffixing bias.