bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual inhibition of histone deacetylases and phosphoinositide 3-kinases: effects on Burkitt lymphoma cell growth and migration
Authors: Ferreira Ana Carolina dos Santos , de-Freitas-Junior Julio Cesar Madureira , Morgado-Díaz Jose Andres , Ridley Anne J , Klumb Claudete Esteves 
Published: November 2015

AbstractBurkitt lymphoma is a highly aggressive non-Hodgkin lymphoma that is characterized by MYC deregulation. Recently, the PI3K pathway has emerged as a cooperative prosurvival mechanism in Burkitt lymphoma. Despite the highly successful results of treatment that use high-dose chemotherapy regimens in pediatric Burkitt lymphoma patients, the survival rate of pediatric patients with progressive or recurrent disease is low. PI3Ks are also known to regulate cell migration, and abnormal cell migration may contribute to cancer progression and dissemination in Burkitt lymphoma. Little is known about Burkitt lymphoma cell migration, but the cooperation between MYC and PI3K in Burkitt lymphoma pathogenesis suggests that a drug combination could be used to target the different steps involved in Burkitt lymphoma cell dissemination and disease progression. The aim of this study was to investigate the effects of the histone deacetylase inhibitor suberoylanilide hydroxamic acid combined with the PI3K inhibitor LY294002 on Burkitt lymphoma cell growth and migration. The combination enhanced the cell growth inhibition and cell-cycle arrest induced by the PI3K inhibitor or histone deacetylase inhibitor individually. Moreover, histone deacetylase inhibitor/PI3K inhibitor cotreatment suppressed Burkitt lymphoma cell migration and decreased cell polarization, Akt and ERK1/2 phosphorylation, and leads to RhoB induction. In summary, the histone deacetylase inhibitor/PI3Ki combination inhibits cell proliferation and migration via alterations in PI3K signaling and histone deacetylase activity, which is involved in the acetylation of α-tubulin and the regulation of RhoB expression.
ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Rα from the cell surface of leukocytes during inflammatory responses
Authors: Yan Isabell , Schwarz Jeanette , Lücke Karsten , Schumacher Neele , Schumacher Valéa , Schmidt Stefanie , Rabe Björn , Saftig Paul , Donners Marjo , Rose-John Stefan , Mittrücker Hans-Willi , Chalaris Athena 
Published: November 2015

Abstract
The cytokine IL-6 is part of a regulatory signaling network that controls immune responses. IL-6 binds either to the membrane-bound IL-6 receptor-α (classic signaling) or to the soluble IL-6 receptor-α (trans-signaling) to initiate signal transduction via gp130 activation. Because classic and trans-signaling of IL-6 fulfill different tasks during immune responses, controlled shedding of the membrane-bound IL-6 receptor-α from the surface of immune cells can be considered a central regulator of IL-6 function. The results from cell culture-based experiments have implicated both a disintegrin and metalloprotease 10 and a disintegrin and metalloprotease 17 in IL-6 receptor-α shedding. However, the nature of the protease mediating IL-6 receptor-α release in vivo is not yet known. We used hypomorphic a disintegrin and metalloprotease 17 mice and conditional a disintegrin and metalloprotease 10 knock-out mice to identify the natural protease of the murine IL-6 receptor-α. Circulating homeostatic soluble IL-6 receptor-α levels are not dependent on a disintegrin and metalloprotease 10 or 17 activity. However, during Listeria monocytogenes infection, IL-6 receptor-α cleavage by the α-secretase a disintegrin and metalloprotease 17 is rapidly induced from the surface of different leukocyte populations. In contrast, CD4-Cre-driven a disintegrin and metalloprotease 10 deletion in T cells did not influence IL-6 receptor-α shedding from these cells after L. monocytogenes infection. A disintegrin and metalloprotease 17 was also required for IL-6 receptor-α ectodomain cleavage and release during endotoxemia. These results demonstrate a novel physiologic role for a disintegrin and metalloprotease 17 in regulating murine IL-6 signals during inflammatory processes.
Treatment of psychosis in prisons and violent recidivism
Authors: Igoumenou Artemis , Kallis Constantinos , Coid Jeremy 
Published: November 2015

BackgroundViolence among released prisoners with psychosis is an important public health problem. It is unclear whether treatment in prison can influence criminal behaviour subsequent to release.AimsTo investigate whether treatment in prison can delay time to reoffending.MethodOur sample consisted of 1717 adult prisoners in England and Wales convicted of a serious violent or sexual offence. We used Cox regression to investigate the effects of treatment received in prison on associations between mental illness and time to first reconviction following release.ResultsPrisoners with current symptoms of schizophrenia reoffended quicker following release. Nevertheless, treatment with medication significantly delayed time to violence (18% reduction). Treatment for substance dependence delayed violent and non-violent reoffending among prisoners with drug-induced psychosis.ConclusionsIdentifying prisoners with psychosis and administering treatment in prison have important protective effects against reoffending. Repeated screening with improved accuracy in identification is necessary to prevent cases being missed.
Effect of the First World War on suicide rates in Ireland: an investigation of the 1864–1921 suicide trends
Authors: Osman Mugtaba , Parnell Andrew C. 
Published: November 2015

SummarySince the proposition of the social integration theory by émile Durkheim, macro-sociological changes have been speculated to affect suicide rates. This study investigates the effect of the First World War on Irish suicide rates. We applied an interrupted time series design of 1864–1921 annual Irish suicide rates. The 1864–1913 suicide rates exhibited a slow-rising trend with a sharp decline from the year 1914 onwards. The odds for death by suicide for males during the 1914–1918 period was 0.811 (95% CI 0.768–0.963). Irish rates of suicide were significantly reduced during the First World War, most notably for males.
Question use in child mental health assessments and the challenges of listening to families
Authors: O'Reilly Michelle , Karim Khalid , Kiyimba Nikki 
Published: November 2015

BackgroundThe mental health assessment is a fundamental aspect of clinical practice and central to this is the use of questions.AimsTo investigate the frequency and type of questions utilised within a child mental health assessment.MethodThe data consisted of 28 naturally occurring assessments from a UK child and adolescent mental health service. Data were analysed using quantitative and qualitative content analysis to determine frequencies and question type.ResultsResults indicated a total of 9086 questions in 41 h across the 28 clinical encounters. This equated to a mean of 3.7 questions per minute. Four types of questions were identified; yes–no interrogatives, wh-prefaced questions, declarative questions and tag questions.ConclusionsThe current format of questioning may impede the opportunity for families to fully express their particular concerns and this has implications for service delivery and training.
Cortical thickness and sulcal depth: insights on development and psychopathology in paediatric epilepsy
Authors: Tosun Duygu , Siddarth Prabha , Levitt Jennifer , Caplan Rochelle 
Published: November 2015

BackgroundThe relationship between cortical thickness (CThick) and sulcal depth (SDepth) changes across brain regions during development. Epilepsy youth have CThick and SDepth abnormalities and prevalent psychiatric disorders.AimsThis study compared the CThick–SDepth relationship in children with focal epilepsy with typically developing children (TDC) and the role played by seizure and psychopathology variables.MethodA surface-based, computational high-resolution three-dimesional (3D) magnetic resonance image analytic technique compared regional CThick–SDepth relationships in 42 participants with focal epilepsy and 46 TDC (6–16 years) imaged in a 1.5 Tesla scanner. Psychiatric interviews administered to each participant yielded psychiatric diagnoses. Parents provided seizure-related information.ResultsThe TDC group alone demonstrated a significant negative medial fronto-orbital CThick–SDepth correlation. Focal epilepsy participants with but not without psychiatric diagnoses showed significant positive pre-central and post-central CThick–SDepth associations not found in TDC. Although the history of prolonged seizures was significantly associated with the postcentral CThick–SDepth correlation, it was unrelated to the presence/absence of psychiatric diagnoses.ConclusionsAbnormal CThick–SDepth pre-central and post-central associations might be a psychopathology biomarker in paediatric focal epilepsy.
Psychiatric intervention and repeated admission to emergency centres due to drug overdose
Authors: Kanehara Akiko , Yamana Hayato , Yasunaga Hideo , Matsui Hiroki , Ando Shuntaro , Okamura Tsuyoshi , Kumakura Yousuke , Fushimi Kiyohide , Kasai Kiyoto 
Published: November 2015

BackgroundRepeated drug overdose is a major risk factor for suicide. Data are lacking on the effect of psychiatric intervention on preventing repeated drug overdose.AimsTo investigate whether psychiatric intervention was associated with reduced readmission to emergency centres due to drug overdose.MethodUsing a Japanese national in-patient database, we identified patients who were first admitted to emergency centres for drug overdose in 2010–2012. We used propensity score matching for patient and hospital factors to compare readmission rates between intervention (patients undergoing psychosocial assessment) and unexposed groups.ResultsOf 29 564 eligible patients, 13 035 underwent psychiatric intervention. In the propensity-matched 7938 pairs, 1304 patients were readmitted because of drug overdose. Readmission rate was lower in the intervention than in the unexposed group (7.3% v. 9.1% respectively, P<0.001).ConclusionsPsychiatric intervention was associated with reduced readmission in patients who had taken a drug overdose.
Fabrication and characterization of CuPc and PCBM based organic solar cell with metal interlayer
Authors: Naveed Muhammad Ahsan , Hussain A. , Islam K. , Akhter P. 
Published: November 2015

Organic solar cells have potential as an alternative to conventional inorganic solar cell due to low processing cost, flexibility and easy fabrication technique.
The goal of this paper is to study the characteristics of the CuPc and PCBM based organic solar cell by introducing a thin layer of Ag at the interface of donor (CuPc) and Acceptor (PCBM), their photovoltaic and optical properties were investigated. The heterojunction solar cells with and without silver inter layer were fabricated through thermal deposition in HR vacuum. The OPV solar cells were characterized using current-voltage graphs, absorbance spectrum and Impedance spectroscopy. Impedance spectroscopy was taken to identify the traps using series resistance, parallel resistance, and Impedance spectrums under different frequencies. Optical behaviors of these devices have been investigated with absorbance spectrum.
Introducing Ag to interfacing point produced traps and these traps causes to decreased Voc, Isc, FF, and efficiency. The effect of silver layer at donor acceptor interface was studied.
Incentive Problems in Performance-Based Online Advertising Pricing: Cost per Click vs. Cost per Action
Authors: Hu Yu (Jeffrey) , Shin Jiwoong , Tang Zhulei 
Published: November 2015

The multibillion-dollar online advertising industry continues to debate whether to use the cost per click (CPC) or cost per action (CPA) pricing model as an industry standard. This paper applies the economic framework of incentive contracts to study how these pricing models can lead to risk sharing between the publisher and the advertiser and incentivize them to make efforts that improve the performance of online ads. We find that, compared with the CPC model, the CPA model can better incentivize the publisher to make efforts that can improve the purchase rate. However, the CPA model can cause an adverse selection problem: the winning advertiser tends to have a lower profit margin under the CPA model than under the CPC model. We identify the conditions under which the CPA model leads to higher publisher (or advertiser) payoffs than the CPC model. Whether publishers (or advertisers) prefer the CPA model over the CPC model depends on the advertisers’ risk aversion, uncertainty in the product market, and the presence of advertisers with low immediate sales ratios. Our findings indicate a conflict of interest between publishers and advertisers in their preferences for these two pricing models. We further consider which pricing model offers greater social welfare. This paper was accepted by J. Miguel Villas-Boas, marketing.
The handling of missing binary data in language research
Authors: Pichette François , Béland Sébastien , Jolani Shahab , Leśniewska Justyna 
Published: November 2015

Researchers are frequently confronted with unanswered questions or items on their questionnaires and tests, due to factors such as item difficulty, lack of testing time, or participant distraction. This paper first presents results from a poll confirming previous claims (Rietveld & van Hout, 2006; Schafer & Gra- ham, 2002) that data replacement and deletion methods are common in research. Language researchers declared that when faced with missing answers of the yes/no type (that translate into zero or one in data tables), the three most common solutions they adopt are to exclude the participant’s data from the analyses, to leave the square empty, or to fill in with zero, as for an incorrect answer. This study then examines the impact on Cronbach’s α of five types of data insertion, using simulated and actual data with various numbers of participants and missing percentages. Our analyses indicate that the three most common methods we identified among language researchers are the ones with the greatest impact n Cronbach's α coefficients; in other words, they are the least desirable solutions to the missing data problem. On the basis of our results, we make recommendations for language researchers concerning the best way to deal with missing data. Given that none of the most common simple methods works properly, we suggest that the missing data be replaced either by the item’s mean or by the participants’ overall mean to provide a better, more accurate image of the instrument’s internal consistency.
Qualitätssicherung in der bibliothekarischen Auskunft: Ein Best- Practice-Ansatz der Universitäts- und Landesbibliothek Münster zur Sicherung der Recherchekompetenz
Authors: Kachel Angelika , Rosenberger Burkard 
Published: November 2015

Zusammenfassung:
In der ULB Münster wurde mit der „Falldatenbank Recherchekompetenz“ ein kooperatives Instrument entwickelt, mit dessen Hilfe Mitarbeiter der Information ihre Recherchekompetenz sichern sowie Auszubildende, Praktikanten und neue Kollegen praxisnah in Recherchefragen eingearbeitet werden können. Dabei werden interessante Fragen aus der mündlichen und schriftlichen Auskunft sowie schwierige Fälle aus der passiven Fernleihe gesammelt und mit einer oder mehreren Lösungen versehen. Neben der Eigeninitiative sowie internen und externen Fortbildungsveranstaltungen ist die Falldatenbank als weiterer Fortbildungsbaustein vollständig in das Alltagsgeschäft der Informationsmitarbeiter integriert.
Immunoassay or LC-MS/MS for the measurement of salivary cortisol in children?
Authors: Bae Yoon Ju , Gaudl Alexander , Jaeger Sonia , Stadelmann Stephanie , Hiemisch Andreas , Kiess Wieland , Willenberg Anja , Schaab Michael , von Klitzing Kai , Thiery Joachim , Ceglarek Uta , Döhnert Mirko , Kratzsch Juergen 
Published: November 2015

AbstractBackground:Dysregulation of the adrenal cortex has been assessed with measurement of salivary cortisol. So far salivary cortisol is routinely measured with immunoassay (IA). However, liquid chromatography-tandem mass spectrometry (MS) is known to offer better specificity. We compared the concentrations of salivary cortisol measured by MS and IA at basal and stress induced conditions and evaluated reasons for the difference in method-dependent cortisol results.Methods:Saliva samples (n=2703) were collected from 169 children (age range: 8–14 years; 81 healthy children; 55 with internalizing and 33 with externalizing disorders) under circadian conditions and during the Trier Social Stress Test for Children (TSST-C). Biochemical analyses were performed with MS for cortisol and cortisone, IA (IBL, RE62011) for cortisol, and enzyme kinetic assay for α-amylase.Results:MS and IA showed mostly comparable results for circadian activity and TSST-C response with similar statistical power. However, IA measured cortisol concentrations about 2.39-fold higher than MS. We found that this difference in measured values between MS and IA was mainly due to different standardization of IA compared to MS. In addition, at cortisol IA concentration below 5 nmol/L, cross-reactivity with cortisone was found to contribute to the lower concordance between MS and IA.Conclusions:Immunoassay and LC-MS/MS were largely comparable in the interpretation of salivary cortisol dynamics in stress research. But the IA method revealed a restricted accuracy in the measuring range below 5 nmol/L.
Cascade assembling of pyrazolin-5-ones and benzylidenemalononitriles: the facile and efficient approach to medicinally relevant spirocyclopropylpyrazolone scaffold
Authors: Vereshchagin Anatoly N. , Elinson Michail N. , Korshunov Aleksander D. , Korolev Victor A. , Egorov Mikhail P. 
Published: November 2015

Abstract
A new cascade reaction provides a direct transformation of pyrazolin-5-ones and benzylidene-malononitriles by the action of bromine into substituted spirocyclopropylpyrazolones in 60–88% yields. This process can be realized in two variants, namely, (1) by treatment with bromine in the presence of base and (2) by treatment with bromine only with heating. These facile and efficient one-step cascade processes lead to the spirocyclopropylpyrazolone framework, which is present in a perspective class of compounds with prominent pharmacological and physiological activity.
Suppressor of cytokine signaling 2 (SOCS2) deletion protects against multiple low dose streptozotocin-induced type 1 diabetes in adult male mice
Authors: Alkharusi Amira , Mirecki-Garrido Mercedes , Ma Zuheng , Zadjali Fahad , Flores-Morales Amilcar , Nyström Thomas , Castrillo Antonio , Bjorklund Anneli , Norstedt Gunnar , Fernandez-Pérez Leandro 
Published: November 2015

Abstract

Background: Diabetes type 1 is characterized by the failure of beta cells to produce insulin. Suppressor of cytokine signaling (SOCS) proteins are important regulators of the Janus kinase/signal transducer and activator of transcription (JAK-STAT) pathway. Previous studies have shown that GH can prevent the development of type I diabetes in mice and that SOCS2 deficiency mimics a state of increased GH sensitivity.

Methodology: The elevated sensitivity of SOCS2–/– mice to GH and possibly to PRL was the rationale to analyze the effects of multiple low dose streptozotocin (MLDSTZ)-induced diabetes in SOCS2–/– mice.

Results: We show that 6-month-old SOCS2–/– mice, but not 2-month-old mice, were less sensitive to MLDSTZ-induced diabetes, compared to controls. MLDSTZ treatment induced glucose intolerance in both SOCS2+/+ and SOCS2–/– mice, as shown by glucose tolerance tests, with SOCS2+/+ mice showing a more marked intolerance, compared to SOCS2–/– mice. Furthermore, insulin tolerance tests showed that the SOCS2–/– mice have an improved hypoglycemic response to exogenous insulin, compared to SOCS2+/+ mice. Moreover, in isolated islets, lipotoxic effects on insulin release could partly be overcome by ligands, which bind to GH or PRL receptors.

Conclusion: Knockdown of SOCS2 makes mice less sensitive to MLDSTZ. These results are consistent with the proposal that elimination of SOCS2 in pancreatic islets creates a state of β-cell hypersensitivity to GH/PRL that mimics events in pregnancy, and which is protective against MLDSTZ-induced type I diabetes in mice. SOCS2-dependent control of β-cell survival may be of relevance to islet regeneration and survival in transplantation.
Knowledge-based 3D reconstruction of the right ventricle: comparison with cardiac magnetic resonance in adults with congenital heart disease
Authors: Trzebiatowska-Krzynska Aleksandra , Driessen Mieke , Sieswerda Gertjan Tj , Wallby Lars , Swahn Eva , Meijboom Folkert 
Published: November 2015

Abstract
Aim: Assessment of right ventricular (RV) function is a challenge, especially in patients with congenital heart disease (CHD). The aim of the present study is to assess whether knowledge-based RV reconstruction, used in the everyday practice of an echo-lab for adult CHD in a tertiary referral center, is accurate when compared to cardiac magnetic resonance (CMR) examination.
Subjects and methods: Adult patients who would undergo CMR for assessment of the RV were asked to undergo an echo of the heart for further knowledge-based reconstruction (KBR). Echocardiographic images were acquired in standard views using a predefined imaging protocol. RV volumes and ejection fraction (EF) calculated using knowledge-based technology were compared with the CMR data of the same patient.
Results: Nineteen consecutive patients with congenital right heart disease were studied. Median age of the patients was 28 years (range 46 years). Reconstruction was possible in 16 out of 19 patients (85%). RV volumes assessed with this new method were smaller than with CMR. Indexed end diastolic volumes were 114±17 ml vs 121±19 ml, P<0.05 and EFs were 45±8% vs 47±9%, P<0.05 respectively. The correlation between the methods was good with an intraclass correlation of 0.84 for EDV and 0.89 for EF, P value <0.001 in both cases.
Conclusion: KBR enables reliable measurement of RVs in patients with CHDs and can be used in clinical practice for analysis of volumes and EFs.
SRM, motor para el desarrollo de la cadena de valor Supplier Relationship Management – SRM gestión de las relaciones con los proveedores
Authors: Mendoza S. Luis Leonardo 
Published: November 2015

En la actualidad se evidencia un creciente interés por buscar las fórmulas que permitan alcanzar mayor eficiencia en los procesos logísticos, analizando de forma exhaustiva las operaciones relacionadas con la distribuci.n, con el almacenamiento, la automatización de procesos y los sistemas de gestión de calidad. Sin embargo, es primordial que en las estrategias empresariales presten suficiente atención a los aspectos relacionados con la gestión del abastecimiento.Una correcta, sustentable y eficiente estrategia de abastecimiento, se basa en la construcción de sólidas sociedades con los proveedores, quienes tras pasar por etapas de preselección y selección, propenderán por garantizar el suministro de bienes y/o servicios, según las condiciones en que se hayan pactado. El adecuado funcionamiento y el cumplimiento de los compromisos contraídos por las partes, bajo un ambiente de profesionalismo y de responsabilidad, conducirá a que se constituyan alianzas colaborativas empresa – proveedor.Ejemplo de ello es el SRM, Supplier Relationship Management, en donde por medio de la constitución de acuerdos basados en intereses comunes, se establecen relaciones estrechas, funcionales y eficientes entre las partes, permitiendo por esta vía la garantía del suministro, y de esta forma, darle un importante impulso para el desarrollo de la cadena de valor.