bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faust de Goethe : l’envers du stéréotype
Authors: Covindassamy Mandana 
Published: July 2024

Si Faust est érigé en mythe national allemand à la fin du xixe siècle, il le doit au regain d’intérêt dont il fait l’objet depuis que Goethe lui a consacré sa célèbre tragédie. Alors qu’elle donne initialement naissance à des interprétations controversées, cette pièce se voit figée en des stéréotypes qui défient la lecture du texte. Au-delà du constat de la réduction à laquelle procèdent ces interprétations, le présent article s’attache à démontrer la plasticité structurelle de l’œuvre de Goethe, qui la dérobe à l’assignation d’un sens fixe. Afin de mettre en évidence le jeu interprétatif complexe dont la pièce crée la possibilité, l’article se penche notamment sur le travail du mythe faustien et de son historicité dans Faust, sur la relecture du genre de la tragédie à laquelle la pièce procède, et sur le dialogue qu’elle entame avec l’histoire littéraire jusque dans les choix métriques. À chaque étape, l’argumentation propose l’étude d’une scène de Faust devenue emblématique afin de mettre en évidence le travail herméneutique auquel la pièce nous invite.
La compétition des stéréotypes dans L’Ange de feu de Valéri Brioussov
Authors: Backès Jean-Louis 
Published: July 2024

Dans son roman L’Ange de feu, publié en 1907, le poète russe Valéri Brioussov raconte une histoire de sorcellerie qui se passe en Allemagne au milieu du xvie siècle. Le héros rencontre le Dr Faust, accompagné de son fidèle serviteur Méphistophélès. L’auteur, qui a réuni une importante documentation, s’appuie sur la fameuse Histoire du docteur Johannes Faustus, publiée en 1587. Il prend soin d’éviter les stéréotypes qui dérivent de la tragédie de Goethe. Il en reprend d’autres : ceux qui ont eu cours à la Renaissance, dans les écrits destinés à inspirer le mépris pour les magiciens. Mais, malgré tout, il ne parvient à oublier ni le Méphisto railleur, cher aux compositeurs d’opéras, ni la figure du mage inspiré, qui hante, à son époque, la pensée occultiste.
Faust outre-Atlantique, Faust d’Amériques ? Éléments de réflexion pour un Faust latino-américain
Authors: Peslier Julia 
Published: July 2024

Au xxe siècle, un vieil Européen, Faust, devient nomade à l’échelle planétaire. Il franchit nouvellement les frontières des littératures nationales au cœur du vieux monde en quittant le site Europe et s’envole (littéralement) vers des contrées plus lointaines, au-delà des océans, et en d’autres continents, langues et cultures. L’Amérique latine sera l’une de ses terres d’accueil. Suffit-il pour autant de lui faire traverser l’océan pour qu’il soit un Faust d’Amérique ? C’est en mettant en contact différentes nouvelles versions de la matière faustienne, et en arpentant l’Argentine, le Chili, le Mexique, le Venezuela et encore le Brésil aux côtés du fameux duo composé par Faust et Méphistophélès, que nous explorons la définition d’un Faust latino-américain. Déracinement et reterritorialisation dans le sertão et la pampa, créolisation et « gaucho-isation » de Faust avec Estanislao del Campo, Borges, Birri, Alfredo Arias, Edwards, Lima et d’autres, pensée de la traduction comme transluciferação avec Haroldo de Campos, les opérations de transferts et de transformations sont légion. Elles nous informent sur des modes de voyage et de plasticité d’une figure mythique, qui s’y découvre de nouveaux métiers (d’ambassadeur, d’écrivain et de traducteur) et apprend à différer et à s’altérer à son tour.
[The plants of <i>I Promessi Sposi</i> recount Alessandro Manzoni]
Authors: Banfi Enrico 
Published: July 2024

If we focus on the wild plants described by Alessandro Manzoni in the novel I Promessi Sposi, it is possible to explore two important dimensions that have received little attention, namely the imaginary but realistic reconstruction of a 17th-century plant landscape and the writer's knowledge of wild flora. Manzoni's botanical expertise was enhanced in the management of the estate in Brusuglio (Milan), where his duties as a farmer put him in daily contact with plants and weeds of all kinds, good or bad for the progress of the estate, which the writer observed with curiosity and attention. Benefiting from this experience, the writer transposed 22 of the different wild species known to him into his novel to give each of them a setting and landscape role in the scenarios of the story's events. Today, these plants tell us about him.

[Article in Italian]
Autoantibodies against beta cells to predict early insulin requirements in pediatric patients with clinically diagnosed type 2 diabetes
Authors: Molina Jorge M , Medina Patricia G , Gomez Rita A , Herrera Julia R , Martínez Nancy L , Hernández Brenda , García Yesenia 
Published: July 2024

BACKGROUND
Autoimmunity has emerged as a probable disease modifier in patients with clinically diagnosed type 2 diabetes mellitus (T2DM), that is, patients who have insulin resistance, obesity, and other cardiovascular risk factors, suggesting that the presence of glutamic acid decarboxylase (anti-GAD65), islet antigen 2 (anti-IA2), and zinc transporter 8 (anti-Zn8T) antibodies could have deleterious effects on beta cell function, causing failure and earlier requirement for insulin treatment.
AIM
To evaluate anti-GAD65, anti-IA2 and anti-Zn8T as predictors of early insulin requirement in adolescents with a clinical diagnosis of T2DM.
METHODS
This was a case–control study in patients with clinically diagnosed with T2DM (68 cases and 64 controls with and without early insulin dependence respectively), male and female, aged 12–18 years. Somatometry, blood pressure, glucose, insulin, C-peptide, glycated hemoglobin A1c, and lipid profiles were assessed. ELISA was used to measure anti-GAD65, anti-IA2, and anti-Zn8T antibodies. Descriptive statistics, Pearson's χ 2 test, Student's t test, and logistic regression was performed. P < 0.05 was considered statistically significant.
RESULTS
There were 132 patients (53.8% female), with a mean age was 15.9 ± 1.3 years, and there was a disease evolution time of 4.49 ± 0.88 years. The presence of anti-GAD65, anti-IA2, and anti-Zn8T positivity was found in 29.5%, 18.2%, and 15.9%, respectively. Dividing the groups by early or no insulin dependence showed that the group with insulin had a higher frequency of antibody positivity: anti-GAD65 odds ratio (OR): 2.42 (1.112–5.303, P = 0.026); anti-IA2: OR: 1.55 (0.859–2.818, P = 0.105); and anti-Zn8T: OR: 7.32 (2.039–26.279, P = 0.002).
CONCLUSION
Anti-GAD65 positivity was high in our study. Anti-GAD65 and anti-Zn8T positivity showed a significantly depleted beta cell reserve phenotype, leading to an increased risk of early insulin dependence.
Functional analysis of the novel mitochondrial tRNATrp and tRNASer(AGY) variants associated with type 2 diabetes mellitus
Authors: Ding Yu , Yu Xue-Jiao , Guo Qin-Xian , Leng Jian-Hang 
Published: July 2024

BACKGROUND
Mutations in mitochondrial tRNA (mt-tRNA ) genes that result in mitochondrial dysfunction play important roles in type 2 diabetes mellitus (T2DM). We pre-viously reported a large Chinese pedigree with maternally inherited T2DM that harbors novel mt-tRNA Trp A5514G and tRNA Ser(AGY) C12237T variants, however, the effects of these mt-tRNA variants on T2DM progression are largely unknown.
AIM
To assess the potential pathogenicity of T2DM-associated m.A5514G and m.C12237T variants at genetic, molecular, and biochemical levels.
METHODS
Cytoplasmic hybrid (cybrid) cells carrying both m.A5514G and m.C12237T variants, and healthy control cells without these mitochondrial DNA (mtDNA) variants were generated using trans-mitochondrial technology. Mitochondrial features, including mt-tRNA steady-state level, levels of adenosine triphosphate (ATP), mitochondrial membrane potential (MMP), reactive oxygen species (ROS), mtDNA copy number, nicotinamide adenine dinucleotide (NAD+)/NADH ratio, enzymatic activities of respiratory chain complexes (RCCs), 8-hydroxy-deo-xyguanine (8-OhdG), malondialdehyde (MDA), and superoxide dismutase (SOD) were examined in cell lines with and without these mt-tRNA variants.
RESULTS
Compared with control cells, the m.A5514G variant caused an approximately 35% reduction in the steady-state level of mt-tRNA Trp (P < 0.0001); however, the m.C12237T variant did not affect the mt-tRNA Ser(AGY) steady-state level (P = 0.5849). Biochemical analysis revealed that cells with both m.A5514G and m.C12237T variants exhibited more severe mitochondrial dysfunctions and elevated oxidative stress than control cells: ATP, MMP, NAD+/NADH ratio, enzyme activities of RCCs and SOD levels were markedly decreased in mutant cells (P < 0.05 for all measures). By contrast, the levels of ROS, 8-OhdG and MDA were significantly increased (P < 0.05 for all measures), but mtDNA copy number was not affected by m.A5514G and m.C12237T variants (P = 0.5942).
CONCLUSION
The m.A5514G variant impaired mt-tRNA Trp metabolism, which subsequently caused mitochondrial dysfunction. The m.C12237T variant did not alter the steady-state level of mt-tRNA Ser(AGY), indicating that it may be a modifier of the m.A5514G variant. The m.A5514G variant may exacerbate the pathogenesis and progression of T2DM in this Chinese pedigree.
Safety of teplizumab in patients with high-risk for diabetes mellitus type 1: A systematic review
Authors: Buddhavarapu Venkata , Dhillon Gagandeep , Grewal Harpreet , Sharma Pranjal , Kashyap Rahul , Surani Salim 
Published: July 2024

BACKGROUND
The incidence of diabetes mellitus type 1 (DM1) has been rising worldwide because of improvements in diagnostic techniques and improved access to care in countries with lower socioeconomic status. A new anti-CD4 antibody, Tep-lizumab, has been shown to delay the progression of DM1 and is the only medication approved for this indication. However, more information is needed about the safety profile of this drug.
AIM
To identify the odds ratios (OR) of systems-based adverse effects for Teplizumab when compared to Placebo.
METHODS
An extensive systematic review was conducted from the inception of the medication until December 31, 2023. All clinical trials and studies that evaluated Teplizumab vs placebo were included in the initial review. The study protocol was designed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines guidelines and was registered in PROSPERO (ID: CRD42024496169). Crude OR were generated using RevMan Software version 5.4.
RESULTS
After screening and review, 5 studies were selected to determine the risk of adverse effects of teplizumab compared to placebo. A total of 561 patients were included in the study population. Total adverse effects and system-based adverse effects were studied and reported. We determined that patients receiving Teplizumab had a higher risk of developing gastrointestinal (GI) (OR = 1.60, 95%CI: 1.01-2.52, P = 0.04), dermatological (OR = 6.33, 95%CI: 4.05-9.88, P < 0.00001) and hematological adverse effects (OR = 19.03, 95%CI: 11.09-32.66, P < 0.00001). These patients were also significantly likely to have active Epstein-Barr Virus infection (OR = 3.16, 95%CI: 1.51-6.64, P < 0.002). While our data showed that patients receiving Teplizumab did have a higher incidence of total adverse effects vs placebo, this finding did not reach statistical significance (OR = 2.25, 95%CI: 0.80-6.29, P = 0.12).
CONCLUSION
Our systematic review suggests that Teplizumab patients are at risk for significant adverse effects, primarily related to GI, dermatological, and hematological systems. The total adverse effect data is limited as study populations are small. More studies should be conducted on this medication to better inform the target population of potential adverse effects.
Patellofemoral Instability Secondary to Trochlear Dysplasia - A Case Report
Authors: Byakika Timothy Kagoda , Mwawingwa Philip Gituri 
Published: July 2024

Patellofemoral joint instability is a debilitating condition that affects the biomechanical relationships between the soft tissues and the bony architecture of the knee joint. Trochlear dysplasia is an identifiable etiology in 85-96% of patients with patellar instability. Trochleoplasty is a surgical procedure that aims at restoring a sulcus or creating a near-normal trochlear deep enough to accommodate the patellar in the trochlear groove, restoring patellofemoral congruence, patella tracking, and biomechanics during flexion and extension. This case report describes a sulcus-deepening trochleoplasty through a superolateral parapatellar arthrotomy in a 15- year-old adolescent who presented with a severe form of patellar instability due to trochlear dysplasia.
Pattern of Recurrence in Early Breast Cancer at a Tertiary Center in Sub-Saharan Africa: A Retrospective Cohort Study
Authors: Munguti Cecilia M. , Mutebi Miriam , Ng'ang'a Mukuhi , Wasike Ronald 
Published: July 2024

Introduction: There is limited data on the recurrence rates and factors that contribute to recurrence in women managed for early breast cancer in sub-Saharan Africa. This study conducted at a tertiary level facility aims to determine the recurrence rates in patients treated for early invasive breast cancer.
Methods: This is a single institution retrospective cohort study of women (18–75 years) treated for early breast cancer from 2009 to 2017. Demographic data, tumor, and treatment-related factors were summarized using descriptive statistics. Survival analysis and Cox proportional hazard regression were performed, with computation of hazard ratios and their 95% confidence intervals.
Results: A total of 239 patients with an initial diagnosis of early breast cancer were identified. The mean age at diagnosis was 51 years (SD 13). The most prevalent molecular subtype was estrogen receptor/progesterone receptor (ER/PR)+ at 76% with only 2.9% having human epidermal growth factor receptor 2 (HER2) overexpressing breast cancer. The overall recurrence was 7.1% with a 1.6% case mortality. The overall 5-year and 10-year survival rate was 94% and 91%, respectively.
Conclusion: Early breast cancer in our setting has a good overall survival and low recurrence rates that are comparable to that found in Western countries.
Multiple antibiotic resistance index of Klebsiella pneumoniae isolated from clinical specimens in a tertiary hospital in Benin City, Nigeria
Authors: Ogefere HO , Idoko MO 
Published: July 2024

Background: Klebsiella pneumoniae is a commensal of the gastrointestinal tract but has been associated with hospital associated- and community infections. In this investigation, K. pneumoniae that was isolated from several clinical specimens of patients at a tertiary hospital in Benin City was evaluated for its multiple antibiotic resistance (MAR) index.
Methods: A total of 100 clinical isolates of K. pneumoniae from the hospital’s inpatients and outpatients were employed. By using conventional microbiological techniques, isolates were identified. Antibiotic susceptibility testing was carried out and MAR index was calculated.
Results: The susceptibility test showed that K. pneumoniae exhibited high level of multidrug resistance with a total of 24 isolates resistant to the 12 antibiotics tested. The MAR index ranged from 0.42 to 1.00 with the mean value of 0.7994. The K. pneumoniae isolates from clinical specimens of inpatients showed a higher MAR index of 0.82 than that of outpatients (0.74).
Conclusion: These findings present a major public health concern. Concerted efforts that emphasize antimicrobial stewardship must be put in place to mitigate this problem.
Cervical cancer screening practices of antenatal clinic attendees in Garki Hospital Abuja, Nigeria
Authors: Isara Alphonsus , PC-Onyekwere CJ 
Published: July 2024

Background: Cervical cancer, a preventable disease, is the fourth most frequent cancer in women worldwide is a major public health problem especially in developing countries. The aim of the study was to assess the knowledge of cervical cancer and practice of cervical cancer screening among antenatal clinic attendees in Garki Hospital Abuja, Nigeria.
Methods: Two hundred and fifteen antenatal clinic attendees selected using systemic sampling techniques participated in this facility-based cross-sectional study. Data was collected using a structured, self-administered questionnaire and analyzed with IBM SPSS version 22.0. Statistical level of significance was set at p < 0.05.
Results: One hundred and twenty-two (57.0%) of the respondents were aged 30 – 39 years, 191 (89.3%) were married, 202 (94.4%) had tertiary level of education while 72 (33.6%) were primipara. Majority 191 (89.3%) were awareness of cervical cancer with health care workers 81 (42.4%) and mass media 72 (37.7%) as the predominant sources of information. Majority 157 (82.2%) mentioned abnormal vaginal bleeding as a symptom of cervical cancer while 28 (14.7%) do not know the symptoms of cervical cancer. Sixty-eight (35.6%) and 30 (15.7%) mentioned multiple sexual partners and early sexual exposures as risk factors for cervical cancer, respectively. Only 31 (16.2%) had screened for cervical cancer. Socio-demographic characteristics were not significantly associated with respondents’ uptake of cervical cancer screening
Conclusion: The awareness concerning cervical cancer was high but the in-depth knowledge of its symptoms and risk factors was generally poor. The uptake of cervical cancer screening was abysmally low.
Assessment of Knowledge, Attitude and Practices of Pharmacy Clients about Antibiotic Use and Misuse in Ogun State, Nigeria
Authors: Joda A.E. , Ezugwu K.S. , Ekpeluchi C. J. 
Published: July 2024

Background: The rise of antimicrobial resistance poses a global health challenge, driven by the widespread misuse of antibiotics. This misuse includes self-medication, sharing of antibiotics and failing to complete prescribed courses. This fosters an environment conducive for antibiotic resistance making future treatment less effective.
Objectives: This study aims to evaluate the knowledge, attitudes, and practices (KAP) of antibiotic use/misuse and their influencing factors among pharmacy clients in Ogun State, Nigeria.
Methods: A descriptive cross-sectional study was carried out in ten (10) community pharmacies obtained from the list provided by the Association of Community Pharmacists of Nigeria, Ogun State branch, across its five zones in Ogun State, Nigeria. Pre-tested questionnaires adapted from previous studies were used to collect data which was entered into Microsoft Excel 2016 and analyzed using the Statistical Package for Social Sciences (SPSS) version 23.0. Descriptive and inferential statistical analyses were carried out with significance level set at ≤0.05.
Results: Good knowledge and practice (KP) scores of pharmacy clients about antibiotic use of 54.5% and 56.2% but poor attitude to antibiotics (60.5%) was documented along with notable misconceptions. Several demographic factors influenced the KP levels including gender (p=0.00027), marital status (p=0.013), religion (p=0.005), and education (p=0.001) for knowledge; and religion (p=0.027) and education (p=0.006) for practices.
Conclusion: The study showed that though moderate levels of KP were obtained, there is a need for targeted interventions to improve public awareness about antibiotics and promote responsible use.
Development and Evaluation of Encapsulated Self-Emulsifying Drug Delivery System of Hydrochlorothiazide
Authors: Essien E.S. , Jackson T.C. , Olorunsola E.O. , Olorunsola E.O. 
Published: July 2024

Background: Formulation of solid self-emulsifying drug delivery system (Solid SEDDS) provides a dual benefit of improved drug stability and enhanced delivery system.
Objective: This study was aimed at developing and evaluating a solid self-emulsifying drug delivery system of hydrochlorothiazide.
Methods: Solubility of hydrochlorothiazide in some oils was determined and pseudo-ternary system of the most effective oil, water and surfactant system was constructed. Four Liquid SEDDSs were formulated to contain Tween 80/oleic acid or PEG 400/oleic acid (surfactant systems) and castor oil combined in ratio 2:8 or 3:7 based on the pseudo-ternary plot. Each preparation was made by adding the drug to the oil/surfactant system and heating up to 60 0C under continuous stirring followed by cooling to room temperature. Viscosity of each Liquid SEDDS was determined; Solid SEDDS was prepared by mixing the Liquid SEDDS with microcrystalline cellulose in 1:2 proportion and then encapsulated. Drug release profile of the Solid SEDDSs in comparison with a marketed product was studied.
Results: Castor oil was found to be the best solvent for hydrochlorothiazide and the viscosity of the Liquid SEDDSs was in the range of 79.41 and 187.32 mPa.s. The in vitro release studies showed 85.46 – 87.17 % drug release from the formulated SEDDSs with ratio 3:7 of surfactant mix being superior; and percentage drug release for each formulation was twice that of the marketed product.
Conclusion: The prepared Solid SEDDS of hydrochlorothiazide exhibited improved drug release characteristics, hence superior to the conventional commercial product.
Rancangan Kontrol Apron Floodlight Berbasis Mikrokontroller Via Telegram Di Bandara Internasional Adi Soemarmo Solo
Authors: Agung Raharjo Muhammad , Akram Fauzan Muhammad , Driyono Bambang 
Published: July 2024

Dalam pelaksanaan On The Job Training penulis sering melaksanakan maintenance ke wilayah airside, terutama pada pada bagian Airfield lighting system. Pada pelaksanaan maintenance teknisi sering kali melakukan komunikasi ke pada pihak ATC (air traffic control) dalam hal menyalakan dan memadamkan apron floodlight. Adapun rumusan masalah pada penelitian ini yaitu Bagimana urutan perancangan atau perakitan kontrol apron floodlight berbasis mikrokontroller via telegram? dan Bagimana cara kerja rancangan dan uji coba hasil rancangan yang dibuat?. Laporan hasil tugas akhir ini dibuat untuk Mengetahui urutan perancangan atau perakitan kontrol apron floodlight berbasis mikrokontroller via telegram dan dapat mengetahui cara kerja rancangan dan uji coba hasil rancangan yang dibuat. Dalam proses perancangan kontrol apron floodlight dilakukan beberapa tahapan yaitu identifikasi penelitian, rencana penelitian sebagai proses pengamatan data, analisis sebagai langkah awal pengumpulan serta penyusunan data, perancangan sebagai tahap pengembangan setelah melakukan analisis, dan implementasi sebagai hasil dari penelitian yang telah dirancang yang akan melakukan pengujian. Sistem yang dirancang ini berbasis mikrokontroller, menggunakan relay arduino sebagai pemutus dan penyambung aliran listrik ke lampu apron floodlight, power supply sebagai pengubah tegangan AC ke DC untuk lampu, serta sebagai catu daya untuk nodeMCU Esp8266, nodeMCU Esp8266 sebagai pengendali utama yang dihubungkan dengan smartphone menggunakan aplikasi telegram. Hasil pengujian prototype kontrol apron floodlight memiliki beban yaitu 4 lampu.