bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ichthyosis Follicularis, Atrichia, and Photophobia (IFAP) Syndrome, Type 2: Clinical Case
Authors: Ambarchyan Eduard T. , Kuzminova Anastasiya D. , Eldarova Totuy K. , Ivanchikov Vladislav V. , Zhurkova Nataliya V. , Vashakmadze Nato D. 
Published: July 2024

Background. Ichthyosis follicularis with atrichia and photophobia (IFAP syndrome), type 2 is a rare hereditary disease from the group of syndromic forms of ichthyosis. It is clinically characterized by triad of non-inflammatory follicular ichthyosis, total or subtotal alopecia at birth or shortly after, and photophobia of different severity. There is no etiotropic therapy for IFAP syndrome, while symptomatic treatment (emollients, keratolytics, retinoids) is aimed on stabilizing the patient’s condition and maintaining the optimal quality of life. About 60 cases of IFAP syndrome have been described worldwide by 2023, and none in Russia.Clinical case description. The girl, 2 years 3 months old, had signs of xeroderma, follicular hyperkeratosis, photophobia with lacrimation, and alopecia. The diagnosis of “ichthyosis follicularis with atrichia and photophobia (IFAP syndrome), type 2, autosomal dominant” was established according to anamnesis, clinical signs, and results of whole-exome sequencing, followed by validation of the identified nucleotide variant chr17:17720597G>A, p.1669C>T (p.Arg557Cys NM_001005291.2) in exon 9 of the SREBF1 gene via direct automatic sequencing in the patient and both parents (not revealed in her parents).Conclusion. Molecular genetic testing is crucial to establish IFAP syndrome as clinical signs of the disease are similar to other dermatoses. However, physicians need to have clinical suspicion when identifying cases of follicular ichthyosis in combination with alopecia and photophobia at or shortly after birth to timely diagnose IFAP syndrome and thus prevent any treatment delays.
Gold, bitcoin and the financial fear gouge
Authors: Cohen Gil 
Published: July 2024

Our study investigates the hedging ability of Gold and Bitcoin to hedge against financial market crashes. We also examined the ability of the VIX fear gouge to improve the ability of those financial assets to hedge financial risks. We found a positive dependency between the current daily prices of Gold and Bitcoin with a stronger impact of Gold on Bitcoin than vice versa. We also find that in recent years (2021-2023), Gold price changes are negatively correlated to yesterday's price change of the S&P500 a day before and positively correlated to yesterday's NASDAQ price change.
Being A Young Scientist : Does Guided Inquiry Affect Students’ Scientific Literacy Skills?
Authors: Dhani Arini Rahma , Agustinah Agustinah 
Published: July 2024

Guided inquiry learning encourages students to be more active in learning so that students' scientific literacy skills can be developed. Solving problems through investigative activities is one of the elements of contextual learning. Contextual learning by solving everyday problems is one aspect of the description of science literacy competencies. The investigation component in guided inquiry is expected to improve students' science literacy. This study aims to determine the effect of guided inquiry learning model on science literacy skills of 4th grade students of SDN Dukuharum Jombang. The population in this study were all 4th grade students of SDN Dukuharum Jombang in semester 1 of the 2022/2023 academic year, while the samples used were classes 4A and 4B. The experimental class and control class each consisted of 20 students. This research is a quantitative study with a quasi-experimental research method with a research design of nonequivalent pretest posttest pretest- posttest control group design. The results of this study indicate that guided inquiry has a significant effect on science literacy skills.
The Influence of Occupational Health And Safety Practices on Organizational Commitment and Job Performance
Authors: Ei Myo Myo , Ekowati Dian , Agustina Tri Siwi , Phyu May Moe Pwint 
Published: July 2024

The aim of this study is to examine the four aspects of workplace health and safety practices: Safety Procedures and Risk Management (SPRM), Safety and Health Rules (SAHR), Occupational Hazard Prevention (OHP), and Organizational Safety Support (OSS) on organizational commitment. Moreover, this study also explores the effect of organizational commitment on the job performance of employees. The sample for the present study consisted of 105 employees who work in construction industries which are located in Mandalay Division, Myanmar. The findings of this study show that the two dimensions of occupational health and safety practices namely: Safety and Health Rules (SAHR) and Organizational Safety Support (OSS) positive effects on organizational commitment that are significant whereas the two dimensions of occupational health and safety practices: Safety Procedures and Risk Management (SPRM) and Occupational Hazard Prevention (OHP) do not affect the organizational commitment of employees significantly. The result also indicated that organizational commitment has a positive and significant effect on the job performance of employees.
Exploratory Factor Analysis for The Development of The 49-Item Children’s Reading Motivation Scale (Crms-49)
Authors: Ontok-Balah Khadiguia 
Published: July 2024

Reading is crucial and serves as a fundamentalbuilding block for learning. There are different instrumentsavailable to assess the reading motivation of grade school childrenbut, caution and careful thought is required because the validity andreliability of these measures cannot be generalized for use due tocultural and contextual differences. The aim of the study was tocreate a valid and reliable self-report measure of the readingmotivation of 280 intermediate-grade school pupils. The results ofthe analysis confirmed that the 49-item Children’s ReadingMotivation Scale (CRMS) developed in this study accounted for28.4% of the variance with three factors such as children&#39;s readingself-efficacy, parental autonomy-supportive reading practices, andchildren&#39;s reading and behavioral problems. The Cronbach’s α ofthe tool was between 0.793 to 0.864 among the three factorsidentified. The measure obtained good construct validity and willprove a useful tool to help Filipino teachers determine theintermediate graders’ motivation to read through their self-efficacyin reading, support practices of their parents in reading, and theirreading and behavioral problems.
Implementation Of The Independent Curriculum In Post-Pandemic Arabic Learning In Madrasah Aliyah Negeri 2 Kulon Progo
Authors: Latifah Muslimah Nurul , Rois Ikhwan Nur , Makruf Imam 
Published: July 2024

This study aims to analyze the form of application after the pandemic independent curriculum at MAN 2 Kulon Progo his type of research is qualitative research with descriptive and explanatory methods. The subjects of this study included school principals, Arabic teachers, and students of class X. Data collection techniques with online observation and documentation. Data analysis techniques with data collection, data reduction, and drawing conclusions. Data validity techniques by triangulating data and re-accuracy of data. The result of this study is that the implementation of an independent curriculum in Arabic subjects at MAN 2 Kulon Progo is divided into three phases: preparation, application, and supervision. In the preparatory phase of learning Arabic, the teacher coordinates with the curriculum team, prepares the administration of learning Arabic, and determines projects to strengthen the profile of Pancasila students and Rahmatan Lil Alamin students. In the application phase of Arabic learning, the teacher applies an eclectic method by giving projects so that contextual knowledge is created. In the supervision phase of learning Arabic, the teacher supervises the understanding of the material and changes in student character by giving projects and evaluating them. يهدف هذا البحث إلى اكتشاف وتحليل شكل تنفيذ المنهج الحرّية في مرحلة ما بعد الجائحة في المدرسة الثانوية الإسلامية الحكومية الثانية كولون فرغو. هذا النوع من البحث هو بحث نوعي ذو مناهج وصفية وتفسيرية. تضمنت موضوعات هذا البحث هي مدير المدرسة ومعلم اللغة العربية وطلاب الصف العاشر. تقنيات جمع البيانات مع المراقبة والتوثيق عبر الإنترنت. تقنيات تحليل البيانات مع جمع البيانات وتقليل البيانات واستخلاص النتائج. تقنية التحقق من صحة البيانات من خلال إجراء تثليث البيانات وإعادة دقة البيانات. نتائج هذا البحث هو أن تنفيذ المنهج الحرّية في المواد العربية في المدرسة الثانوية الإسلامية الحكومية الثانية كولون فرغو ينقسم إلى ثلاث مراحل ، وهي: المرحلة الإعدادية ومرحلة التنفيذ ومرحلة الإشراف. في المرحلة التحضيرية لتعلم اللغة العربية ، يقوم المعلم بالتنسيق مع فريق المناهج ، وإعداد إدارة تعلم اللغة العربية ، وتحديد المشاريع لتعزيز صورة طلاب بانكاسيلا وطلاب رحمان ليل الأمين. في مرحلة التطبيق لتعلم اللغة العربية ، يطبق المعلم طريقة انتقائية من خلال تقديم المشاريع بحيث يتم إنشاء التعلم السياقي. في مرحلة الإشراف على تعلم اللغة العربية ، يشرف المعلم على فهم المادة والتغيرات في شخصية الطالب من خلال تقديم المشاريع ثم تقييمها..
A case study on cerebrovascular accident
Authors: Kumari Sujata 
Published: July 2024

CVA is a significant global health problem and a major cause of mortality and morbidity in developed countries. Cerebral stroke (CVA) is a medical emergency that can cause permanent neurological damage or even death. According to the WHO statistics, stroke was the second most frequent cause of death worldwide in 2012 and the main cause of disability.The present study reported 59 years male ,married, hailing from Kokrajhar came to BH admitted in Intensive Care Unit on 13/08/2023 with the complain of Syncope, Not able to move right side of the body since 4 days,Face drooping at right side since 4 days,Loss of sensation in right side of the body since 4 days,Not able to eat food properly since 4 days,Difficulty speech since 4 days ,Patient was unconscious and was transferred to the ICU in stretcher and after various lab investigation, diagnostic procedures, patient was diagnosed as CVA and was treated with Tissue Plasminogen Activator and is under observation
A computational study of the use of hydrogen peroxide as pilot fuel for a homogeneous mixture of ammonia/hydrogen in a compression ignition engine
Authors: Tingas Efstathios-Alexandros , Taylor Alexander M. K. P. , Hardalupas Yannis 
Published: July 2024

We report a computational investigation of a compression ignition (CI) engine (compression ratio: 17.6, displacement volume: 1.3 L) where the main fuel is a homogeneous mixture of ammonia (70-60% vol%) and hydrogen (30-40% vol%), with a global equivalence ratio varying between 0.44 and 0.5, depending on the H2/NH3 ratio. The novelty of this study is that it employs a pilot injection of hydrogen peroxide to initiate ignition, without the use of any air or charge preheating (the temperature/pressure at intake BDC are 330 K/1.4 atm, representing mild boost an defficeint intervooling). Hydrogen peroxide (H2O2) has the attributes that it can be produced from renewable sources, and it is already widely manufactured, distributed, and stored, with diverse applications (as an aqueous solution of H2O2 with shares up to 30 vol%). The main advantage of using H2O2 as pilot fuel, as opposed to other more conventional ones (e.g., diesel), is that it contains no carbon, and hence produces no CO2 and particulate matter (PM). The computational investigation was conducted with an advanced commercial stochastic engine model that has been previously validated. The investigation was primarily focused on assessing the effects of using hydrogen peroxide in aqueous solution as pilot fuel on engine efficiency, combustion phasing and NOx emissions. These three aspects were investigated over a range of engine speeds (750-1,750 rpm) in view of: (i) the variation of the mass of the directly injected (DI) aqueous solution (0.1-10 mg); (ii) the variation of the H2O2 share (15-50%) in the directly injected (DI) aqueous solution; (iii) the variation of the start of injection (from -20 to -4 CAD aTDC) and injection duration (1-8 CAD). There is a strong effect of the peroxide in advancing combustion timing (CAD50 is advanced by up to 15 CAD) and in decreasing combustion duration (CAD90-CAD10 decreases up to 10 CAD), and peroxide readily enables medium engine loads which are the ones investigated in this work. Indicated thermal efficiencies above 50% were readily achieved at all engine speeds and, with a 30 vol% peroxide share in the solution, the pressure rise rate was always below 30 bar/ms. However, the NOx emissions in all cases exceeded the IMO’s Tier III standard. Possible ways to tackle this would be either the use of exhaust gas recirculation, or optimisation of the injection strategy, or the use of aftertreatment. For most cases, on a volume basis, the required aqueous H2O2 amount is 3% of the main fuel while on an energy basis this translates to 1.1% of the main fuel blend. The results reported in this initial study are promising because it is possible to ignite a premixed charge on the basis of a small pilot volume of commercially available hydrogen peroxide solutions.
Quels défis au développement de la production porcine en agriculture biologique en France ?
Authors: MONTAGNE Lucile , ALIBERT Laurent , MD BONNEFONT Cécile , CHOISIS Jean-Philippe , DURPOIX Amandine , GILBERT Hélène , HARCHAOUI Souhil , LARZUL Catherine , LEBRET Benedicte , LOMBARD Sarah , MARTEL Gilles , MORAINE Marc , PICGIRARD Laurent , PUECH Thomas , FAURE Justine 
Published: July 2024

La production porcine française en AB est très diversifiée de par ses élevages, notamment en termes de taille avec de nombreux ateliers à faibles effectifs ; de par la commercialisation des produits, avec une filière longue bien implantée dans le grand ouest de la France, et des filières courtes plus territorialisées ; et de par la multiplicité de ses acteurs spécifiques à l’AB ou mixtes. Bien que le nombre de truies certifiées en AB ait doublé entre 2016 et 2021, il ne représente que 1,9 % du cheptel français. Face à ce constat, une étude a été réalisée par le consortium ORIGAMI (INRAE-Métabio) pour comprendre les freins et leviers au développement de cette production. Des entretiens de 21 porteurs de projets ont permis d’identifier 164 freins et 231 leviers. Des analyses en composantes multiples suivies d’une classification ont mis en évidence sept types de freins et six types de leviers en fonction de leur niveau d’organisation (de l’animal au territoire) et du maillon de la filière qu’ils concernent (de l’agrofourniture à la consommation). L’interprétation de ces typologies permet d’identifier des thèmes de recherche pour relever les principaux défis identifiés. Ces thèmes concernent l’acquisition de références techniques spécifiques pour l’AB, la meilleure articulation entre filières et territoires, la promotion des débouchés des produits, mais aussi la formation des acteurs actuels et futurs et la communication auprès du grand public. Ces sujets sont des pistes de réflexion pour la construction de projets transdisciplinaires de recherche ou recherche-action avec les acteurs des filières.
Gustatory-Visual Interaction in Human Brain Cortex: fNIRS Study
Authors: Jezierska Karolina , Cymbaluk-Płoska Aneta , Zaleska Justyna , Podraza Wojciech 
Published: July 2024

Background: many studies, on for example taste-visual dissonance, have shown that the influence of the visual cortex on taste sensation is enormous. The aim of the presented work is to investigate, using fNIRS, whether a taste stimulus, in this case the taste of bitter, also causes stimulation of the visual cortex in fNIR study. Methods: 51 participants (204 examinations, 9 996 records) were examined with fNIRS, which collects signals from whole left hemisphere. Differences between the maximum and minimum changes in oxyHb concentrations (ΔoxyHb) for the areas of the brain cortex considered responsible for recording visual and gustatory signals were analyzed. Protocol I, II, III and IV – activation with distillate water, coffee with lower concentration, reference (no stimulation) and coffee with higher concentration respectively, were used. Results: We recorded high signals for teste activation on channels covered gustatory cortex, which confirms the correctness of the choice of research method. What seems important, and somewhat surprising, is the fact that we also received high signals for the channels 45-49, which cover the visual cortex. The statistical analysis does not show any statistical differences between the protocols I, II and IV (different taste activation – water, coffee A and coffee B) for specific channels. As a results of the analysis of the correlation between the subjective bitterness assessment solutions, and the signal ΔoxyHb height, it was observed that statically important correlation, although weak, occurs only for 14 and gustatory channels, only for coffee with a higher concentration. Additionally we recorded the only statistically significant difference between women and men for protocol I (water), where the ΔoxyHb signal was twice as high for women. Conclusions: In conclusion, we can clearly state that the senses of sight and taste work closely together. Moreover, this cooperation is not one-sided - not only the visual activation affects the perception of taste, but interestingly, the taste stimulus can generate a hemodynamic response - activity in the visual cortex.
Novel Methods for Cost-Effectively Generating a Heterogeneous Core Model Based on Scale Change of Nuclear Magnetic Resonance and X-ray Computed Tomography Data
Authors: Zhou Zili , Jia Hu , Zhang Rui 
Published: July 2024

Summary
In response to the constraint on model size imposed by computational capabilities and the inability to capture the heterogeneity within the core and its dynamic oil displacement characteristics, this paper proposes two novel methods for cost-effectively modeling heterogeneous core models based on scale changes of nuclear magnetic resonance (NMR) and X-ray computed tomography (X-CT) data, respectively. By utilizing NMR and X-CT techniques to characterize information at the subcore scale, we establish a more realistic model at the core scale. First, by using a method of setting up inactive grids, a homogeneous model is established to better represent the actual cross-section of the core. By fitting the core water displacement experimental data, a random heterogeneous core model based on the NMR-T2 spectrum is established by using the modified Schlumberger-Doll Research (SDR) model and complementarity principle. The numerical simulation results show that the random heterogeneous core model partially reflect the heterogeneity of the core, but the simulation results are unstable. Building on this, a deterministic homogeneous core model is established based on X-CT scan data by using the modified Kozeny-Carman model and pore extraction method. Sensitivity analysis results suggest that higher grid accuracy leads to a better fitting effect, with the axial plane grid accuracy impacting the model water-drive process more significantly than that of the end plane. The study paves the way for the rapid and accurate establishment of core models.
Modulation of Large Rhythmic Depolarizations in Human Large Basket Cells by Norepinephrine and Acetylcholine
Authors: Feldmeyer Dirk , Yang Danqing , Qi Guanxiao , Ort Jonas , Witzig Victoria , Bak Aniella , Delev Daniel , Koch Henner 
Published: July 2024

Abstract

Rhythmic brain activity is critical to many brain functions and is sensitive to neuromodulation, but so far very few studies have investigated this activity on the cellular level in vitro in human brain tissue samples. This study reveals and characterizes a novel rhythmic network activity in the human neocortex. Using intracellular patch-clamp recordings of human cortical neurons, we identify large rhythmic depolarizations (LRDs) driven by glutamate release but not by GABA. These LRDs are intricate events made up of multiple depolarizing phases, occurring at ~ 0.3 Hz, have large amplitudes and long decay times. Unlike human tissue, rat neocortex layers 2/3 exhibit no such activity under identical conditions. LRDs are mainly observed in a subset of L2/3 interneurons that receive substantial excitatory inputs and are likely large basket cells based on their morphology. LRDs are highly sensitive to norepinephrine (NE) and acetylcholine (ACh), two neuromodulators that affect network dynamics. NE increases LRD frequency through β-adrenergic receptor activity while ACh decreases it via M4 muscarinic receptor activation. Multi-electrode array recordings show that NE enhances and synchronizes oscillatory network activity, whereas ACh causes desynchronization. Thus, NE and ACh distinctly modulate LRDs, exerting specific control over human neocortical activity.
Epiretinal Membrane Peeling in Eyes with Pseudophakia: Prognostic and Morphological Factors of Visual Outcomes
Authors: Tsen Chui Lien , Lee Tzu Ying , Wu Tsung Tien 
Published: July 2024

Abstract

Background
Epiretinal membrane (ERM) is a sight-threatening disorder, and diagnosis can be delayed. In this study, spectral domain optical coherence tomography (SD-OCT) was used to investigate the predictive factors of visual outcomes in patients with pseudophakic ERM following surgery.
Methods
The records of 61 patients with pseudophakic eyes (61 eyes) with ERM who underwent PPV, ERM peeling, and ILM peeling were retrospectively reviewed. OCT features such as central foveal thickness (CFT), cotton ball sign, ERM foveoschisis, ellipsoid zone (EZ) disruption, external limiting membrane (ELM) disruption, ectopic inner foveal layer (EFIL), disorganization of the retinal inner layers (DRIL), dissociated optic nerve fiber layer (DONFL), and microcystic macular edema (MME), as well as surgical factors, were compared before and after surgery. The correlations between the OCT and surgical factors and change of best-corrected visual acuity (BCVA) before and after the surgery were examined.
Results
The mean follow-up time was 6 months. The BCVA (P < 0.01) and CFT (P < 0.01) showed significant improvements after ERM removal (P < 0.01). Cotton ball sign and DRIL exhibited statistically significant improvement after ERM removal. ERM-foveoschisis (P = 0.015) and MME (P = 0.009) were significantly correlated with less improvement of visual acuity. Better visual acuity before surgery was significantly associated with better improvement of visual acuity (P < 0.001).
Conclusions
Better baseline visual acuity is correlated with better visual acuity improvement after surgery, while ERM foveoschisis and MME identified preoperatively on OCT are associated with relatively less improvement of visual acuity.