bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daily Assistance for Individuals With Dementia via Videophone
Authors: Yasuda Kiyoshi , Kuwahara Noriaki , Kuwabara Kazuhiro , Morimoto Kazunari , Tetsutani Nobuji 
Published: June 2013

We previously developed remote reminiscence conversation and schedule prompter systems via the videophone to improve psychological stability and to assist individuals with dementia to perform household tasks. Our results showed that the psychological stability of 1 patient persisted for 3 hours after remote conversations. The task completion rate afforded by the schedule prompter system, which displays a video reminder series automatically, was 52%. In the present study, we also investigated whether psychological stability was sustained in other patients. Furthermore, motivational prompter videos were added to enhance the original schedule prompter system. We found that 1 in 4 patients living at home showed greater stability while conversing with a conversation partner on the videophone than while watching television programs, and that she remained stable for 3 hours after remote conversations. The task completion rate afforded by the revised schedule prompter system was 82%. These 2 remote systems are promising tools for assisting individuals with dementia in their daily lives.
Meta-Analysis of the Association Between Urokinase-Plasminogen Activator Gene rs2227564 Polymorphism and Alzheimer’s Disease
Authors: Wu Wenlong , Jiang Hong , Wang Meiyun , Zhang Dongfeng 
Published: June 2013

Objective: The association between urokinase-plasminogen activator (PLAU) gene rs2227564 polymorphism and Alzheimer’s disease (AD) risk has been widely reported across different ethnic populations, with inconsistent results. Thus, we performed a meta-analysis to assess the association between PLAU rs2227564 polymorphism and AD risk. Methods: Fixed or random effect model was used as the pooling method to assess the basis of homogeneity test among studies. Summarized estimation of odds ratio (OR) and 95% confidence interval (CI) were calculated. Heterogeneity among studies was evaluated using Q test and I2. Publication bias was estimated using Harbord’s test. Results: A total of 27 studies (comprising 6100 AD cases and 5718 controls) were included in this meta-analysis. The present meta-analysis showed a significant increased effect of T allele on risk of AD in dominant model (fixed effect model [FEM] OR 1.123, 95% CI 1.025-1.231) and heterozygote comparison (CT vs CC; FEM OR 1.126, 95% CI 1.027-1.235). No publication bias was detected. Conclusion: This meta-analysis showed that T allele of rs2227564 polymorphism in PLAU gene could increase the effects on risk of AD, and this result needs to be confirmed by further studies.
Aquatic Training for Ankle Instability
Authors: Asimenia Gioftsidou , Paraskevi Malliou , Polina Sofokleous , Anastasia Beneka , Kyriakos Tsapralis , Georgios Godolias 
Published: June 2013

The aim of the present study was to evaluate balance deficits after an ankle sprain in collegiate students and to examine the effectiveness of 2 different balance rehabilitation programs on balance ability. Thirty collegiate students with functional ankle instability were randomly divided into 2 groups. Both groups followed an intervention balance program for 6 weeks, 3 times per week, 20 minutes per session, using balance boards. One of the 2 training groups performed the exercises on the ground—the “Land” group ( n = 15), and the other in a swimming pool—the “Aquatic” group ( n = 15). Balance ability was assessed before and after the 6-week intervention program. Balance assessments included static (stability indices: total, anterior–posterior, medial–lateral) and dynamic (dynamic moving the cursor) stability tests on the Biodex Stability System (Biodex, Inc, Shirley, NY). The results showed that in both training groups balance ability of the injured leg was significantly improved after the training period. In the final measurements, no statistically significant differences between the injured and healthy limb were found. The present study indicates that the performance of balance exercises in or out of water by collegiate students with functional ankle instability improves their balance ability. Level of Evidence: Therapeutic, Level 1
Retrocalcaneal Pain After the Repair of Acute Achilles Tendon Rupture
Authors: Lui Tun Hing 
Published: June 2013

Pain in the posterosuperior portion of the calcaneus can be caused by a retrocalcaneal bursitis, enlargement of the superior bursal prominence of the calcaneus, insertional Achilles tendinopathy, stress fracture of the calcaneus, or inflammation of an adventitious bursa between the Achilles tendon and the skin. Hypertrophied tendon impinging on the posterosuperior calcaneal tuberosity can be a cause of retrocalcaneal pain after repair of acute rupture of the Achilles tendon. This can be effectively treated by endoscopic calcaneoplasty. Levels of Evidence: Therapeutic, Level IV, Case Report
Inhibiting retinoic acid signaling ameliorates graft-versus-host disease by modifying T-cell differentiation and intestinal migration
Authors: Aoyama Kazutoshi , Saha Asim , Tolar Jakub , Riddle Megan J. , Veenstra Rachelle G. , Taylor Patricia A. , Blomhoff Rune , Panoskaltsis-Mortari Angela , Klebanoff Christopher A. , Socié Gérard , Munn David H. , Murphy William J. , Serody Jonathan S. , Fulton LeShara M. , Teshima Takanori , Chandraratna Roshantha A. , Dmitrovsky Ethan , Guo Yanxia , Noelle Randolph J. , Blazar Bruce R. 
Published: June 2013

Key PointsExpression and function of vitamin A metabolizing enzymes are increased in the intestine and mesenteric lymph nodes during GVHD. Inhibiting donor T-cell RAR signaling reduces Th1 differentiation, gut homing, and GVHD while preserving graft-versus-lymphoma effects.
A prospective study of 67 serum immune and inflammation markers and risk of non-Hodgkin lymphoma
Authors: Purdue Mark P. , Hofmann Jonathan N. , Kemp Troy J. , Chaturvedi Anil K. , Lan Qing , Park Ju-Hyun , Pfeiffer Ruth M. , Hildesheim Allan , Pinto Ligia A. , Rothman Nathaniel 
Published: June 2013

Key PointsElevated levels of BCA-1, sTNFR2, and sVEGFR2 are associated with increased risk for NHL several years after blood collection.
Innate immune responses against Epstein Barr virus infection
Authors: Chijioke Obinna , Azzi Tarik , Nadal David , Münz Christian 
Published: June 2013

ABSTRACTEBV persists life-long in &gt;95% of the human adult population. Whereas it is perfectly immune-controlled in most infected individuals, a minority develops EBV-associated diseases, primarily malignancies of B cell and epithelial cell origin. In recent years, it has become apparent that the course of primary infection determines part of the risk to develop EBV-associated diseases. Particularly, the primary symptomatic EBV infection or IM, which is caused by exaggerated T cell responses, resulting in EBV-induced lymphocytosis, predisposes for EBV-associated diseases. The role of innate immunity in the development of IM remains unknown. Therefore, it is important to understand how the innate immune response to this virus differs between symptomatic and asymptomatic primary EBV infection. Furthermore, the efficiency of innate immune compartments might determine the outcome of primary infection and could explain why some individuals are susceptible to IM. We will discuss these aspects in this review with a focus on intrinsic immunity in EBV-infected B cells, as well as innate immune responses by DCs and NK cells, which constitute promising immune compartments for the understanding of early immune control against EBV and potential targets for EBV-specific immunotherapies.
Mixed features of depression: why DSM-5 is wrong (and so was DSM-IV)
Authors: Koukopoulos Athanasios , Sani Gabriele , Ghaemi S. Nassir 
Published: July 2013

SummaryThe DSM system has never acknowledged a central position for mixed states; thus, mixed depressions have been almost completely neglected for decades. Now, DSM-5 is proposing diagnostic criteria for depression with mixed features that will lead to more misdiagnosis and inadequate treatment of this syndrome. Different criteria, based on empirically stronger evidence than exists for the DSM-5 criteria, should be adopted.
Tłumaczenie w tandemach: nowe możliwości w dydaktyce tłumaczeniowej
Authors: Tomaszkiewicz Teresa 
Published: July 2013

Translation in tandems: new possibilities in translation teaching
The introduction of Think‑aloud Protocols (TAPs) in the analysis of the translating process dates back to the mid‑eighties. Their goal was to study the cognitive components of translation. Conducted through collaborative translation, they were as well a means of teaching future translators. However after a fair amount of success in the 90s, they faced more criticism in the years 2000. They were reproached their impossibility to distinguish what is essential from that which is not and the lack of exhaustivity of the data thus obtained. However, in the past few years, some have returned to those problems, showing, for example, the usefulness of such methods of analysis in the studies of linguistical problems in the translating process. This article shall present the results of experiments of collaborative translation carried out by, on one hand, students and on the other, academic researchers and translators. The talks carried out by the two partners shed a light on the different problems facing translators and the different strategies they use to solve them. The research now conducted for a while shows that the analysis of translating behaviors during the understanding and producing stages of a translation is useful not only to correct certain flawed behaviors on the part of the students but also to improve the training of professional translators, meeting the needs of, among others, continuing education.
Action Research in Translation Studies
Authors: Piotrowska Maria 
Published: July 2013

Action Research in Translation Studies. Self-reflection in translation research training
Demonstrating a diversity within TS research, the study enquires into ARTS as a new methodology. The aim of the paper is to define ARTS, localize it among major TS research models, present its components and characteristics and argument for its usefulness and relevance in translator training. Basic assumptions of this methodology are illustrated on the chosen example of an M.A. project, namely translation action with critical reflection, implementing the practitioner‑researcher’s knowledge and experience, and strategic translating in a cyclic process. Implementing ARTS in translator education is a methodological response to a greater professionalization of the discipline and Kiraly’s modern educational model with student being an active participant‑translator in the process of training.
The semiotic resources of comics in movie adaptation: Ang Lee’s Hulk (2003) as a case study
Authors: Bateman John A. , Veloso Francisco O. D. 
Published: July 2013

Abstract
In this article, we apply methods under development in socio-functional semiotics to explore the transfer of resources originally developed for comics to the medium of film. We illustrate this concretely with respect to extracts taken from Ang Lee’s Hulk (2003), a film we consider unique in its particular appropriation of expressive resources from the comic medium. Hulk is often been singled out in discussions of the relations between comics and film because many of the design decisions taken in the film evoke aspects of the comic page. Here, we argue that its use of the resources of comics goes substantially beyond ‘evocation’: Hulk is best considered a highly experimental hybrid, taking resources that were initially essentially comics based and ‘translating’ these filmically in order to extend the medium of film in interesting ways. We show this in two respects: first, we consider the filmic deployment of comicbook conventions for expressing movement; second, we establish that the film’s use of split-screen techniques extends the ability of film to express narrative continuity and connection between perspectives.
Comparison of PR3-ANCA specific assay performance for the diagnosis of granulomatosis with polyangiitis (Wegener’s)
Authors: Radice Antonella , Bianchi Laura , Maggiore Umberto , Vaglio Augusto , Sinico Renato A. 
Published: July 2013

Abstract

Background: PR3-ANCA, the serological marker of granulomatosis with polyangiitis (GPA), is usually detected by immunometric assays, with purified PR3 directly coated onto the solid-phase. Novel methods for PR3-ANCA detection have been developed to improve the performance of traditional PR3-ANCA specific assays, but little is known about their diagnostic performance in real-life clinical settings. This study aimed to compare the performance of nine different commercial PR3-ANCA specific assays, including traditional and newer ones, for the diagnosis of GPA.

Methods: The evaluated assays for PR3-ANCA detection were representative of the first, second, and third generation tests (direct, capture and anchor assays, respectively). A third-generation assay employing both human and recombinant PR3 was also evaluated. The study population consisted of 55 GPA patients, 175 disease controls (representing most diseases in differential diagnosis with primary small-vessel vasculitis) including 52 with microscopic polyangiitis, and 20 healthy subjects. We performed the primary evaluation of test sensitivity using cut-off points which provided adequate and identical specificity for each test.

Results: Although specificity and area under the ROC curve did not differ significantly between the different assays, substantial differences in sensitivity at 98%-specificity were found in some instances (p<0.001). Compared to first generation direct PR3-ANCA specific assays, some of the second and third generation tests increased the positive predictive value (PPV) for GPA diagnosis.

Conclusions: Some of the newer PR3-ANCA specific assays have better PPV than traditional ones.
Certified Miniaturized Charpy Specimens for the Indirect Verification of Small-Size Impact Machines
Authors: Lucon Enrico 
Published: June 2013

Abstract
Small specimen test techniques are becoming ever more popular as the need increases to characterize mechanical properties by the use of the smallest possible amount of material, because of various restrictions on material availability, irradiation, testing space, and other factors. The National Institute of Standards and Technology (NIST) is currently developing certified miniaturized Charpy V-notch (MCVN) specimens for the indirect verification of small-scale impact testing machines. The same materials used for NIST standard verification specimens are being evaluated at three energy levels (low, high, and super-high). Two specimen types are being investigated, denominated KLST (from the German Kleinstprobe, or “small specimen”) and RHS (reduced half-size). Several instrumented impact tests on miniaturized KLST and RHS specimens of low, high, and super-high energy have been performed and analyzed. The variability of MCVN data has been compared to that of full-size Charpy data from the same lots of test specimens. Although this can be considered as just the preliminary phase of this project, the results indicate that MCVN verification specimens can be used for the indirect verification of small-scale instrumented impact testers, both in terms of absorbed energy and maximum force.
Is There Possible Bias in ASTM E112 Planimetric Grain Size Measurements?
Authors: Vander Voort George F. 
Published: June 2013

Abstract
The claim made by Li in 1995 and 2011 publications that the Jeffries planimetric method of determining grain size presented in ASTM E112, as well as in DIN 50601 (it is the standard for every national and international grain size test method and is described in every textbook on quantitative metallography), is wrong and produces biased grain size ratings when the counts are low is incorrect. Li based this statement upon theoretical considerations described by Saltykov, who proposed using rectangles for the planimetric method, rather than circles, to minimize bias at low counts of the number of grains inside the circle. Saltykov, however, did not publish actual test data to back up this proposition. The count levels mentioned are far below those recommended by ASTM E112 for these methods, but they could be encountered in manual measurements of the size of very coarse grains (which might be performed but is rarely done). Actual grain size measurements using both test circles and rectangles, with a very wide range of grains within the test figures and intersecting their borders, showed that the ASTM Jeffries planimetric and Hilliard single-circle intercept methods produced statistically identical measures of the ASTM grain size G down to count levels far below what is recommended—down to 30 for (ninside + 0.5nintercepted) for the planimetric method and down to 20 grain boundary intersections (Pintersections) for the intercept method (well below the recommended minimums of 50 and 35, respectively). At levels below these limits, bias was small—mainly data scatter was observed at counts less than 10 for both methods. The Saltykov planimetric method using rectangles gave the best data, identical to the ASTM E112 data, with statistically identical grain size values down to 10, and it was bias free, but it also exhibited data scatter at counts less than 10. Li's counting method, however, produced more bias at low counts than any other method. His claims have no validity. His model did not evaluate the effect of varying the counting conditions, which was the basis of his claim about the creation of bias. Also, he did not do actual tests to prove that his model was valid and that his claim was correct. Models do not have any validity if they do not test the actual conditions and are not verified by actual experimental data.
Pregnancy outcomes in women with severe hypothyroidism
Authors: Hirsch Dania , Levy Sigal , Nadler Varda , Kopel Vered , Shainberg Bracha , Toledano Yoel 
Published: June 2013

ObjectiveHypothyroidism during pregnancy has been associated with adverse obstetrical outcomes. Most studies have focused on subjects with a mild or subclinical disorder. The aims of the present study were to determine the relative rate of severe thyroid dysfunction among pregnant women with hypothyroidism, identify related factors and analyse the impact on pregnancy outcomes.DesignA retrospective case series design was employed.MethodsThe study group included 101 pregnant women (103 pregnancies) with an antenatal serum TSH level >20.0 mIU/l identified from the 2009–2010 computerised database of a health maintenance organisation. Data were collected from the medical records. Pregnancy outcomes were compared with those of a control group of 205 euthyroid pregnant women during the same period.ResultsThe study group accounted for 1.04% of all insured pregnant women with recorded hypothyroidism during the study period. Most cases had an autoimmune aetiology. All women were treated with levothyroxine (l-T4) during pregnancy. Maximum serum TSH level measured was 20.11–150 mIU/l (median 32.95 mIU/l) and median serum TSH level 0.36–75.17 mIU/l (median 7.44 mIU/l). The mean duration of hypothyroidism during pregnancy was 21.2±13.2 weeks (median 18.5 weeks); in 36 cases (34.9%), all TSH levels during pregnancy were elevated. Adverse pregnancy outcomes included abortions in 7.8% of the cases, premature deliveries in 2.9% and other complications in 14.6%, with no statistically significant differences from the control group. Median serum TSH level during pregnancy was positively correlated with the rate of abortions+premature deliveries and rate of all pregnancy-related complications (P<0.05).ConclusionsAbortions and premature deliveries occur infrequently in women with severe hypothyroidism. Intense follow-up and l-T4 treatment may improve pregnancy outcomes even when target TSH levels are not reached.
A Reappraisal of the Diagnostic and Therapeutic Management of Uncommon Histologies of Primary Ocular Adnexal Lymphoma
Authors: Ponzoni Maurilio , Govi Silvia , Licata Giada , Mappa Silvia , Giordano Resti Antonio , Politi Letterio S. , Spagnuolo Lorenzo , Di Cairano Eliana Sara , Doglioni Claudio , Ferreri Andrés J. M. 
Published: June 2013

Abstract
Lymphoma is the most common malignancy arising in the ocular adnexa, which includes conjunctiva, lachrymal gland, lachrymal sac, eyelids, orbit soft tissue, and extraocular muscles. Ocular adnexal lymphoma (OAL) accounts for 1%–2% of non-Hodgkin lymphoma and 5%–15% of extranodal lymphoma. Histology, stage, and primary localizations are the most important variables influencing the natural history and therapeutic outcome of these malignancies. Among the various lymphoma variants that could arise in the ocular adnexa, marginal zone B-cell lymphoma (OA-MZL) is the most common one. Other types of lymphoma arise much more rarely in these anatomical sites; follicular lymphoma is the second most frequent histology, followed by diffuse large B-cell lymphoma and mantle cell lymphoma. Additional lymphoma entities, like T-cell/natural killer cell lymphomas and Burkitt lymphoma, only occasionally involve orbital structures. Because they are so rare, related literature mostly consists of anecdotal cases included within series focused on OA-MZL and sporadic case reports. This bias hampers a global approach to clinical and molecular properties of these types of lymphoma, with a low level of evidence supporting therapeutic options. This review covers the prevalence, clinical presentation, behavior, and histological and molecular features of uncommon forms of primary OAL and provides practical recommendations for therapeutic management.