bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of family-based intervention programs on objectively measured physical activity in children under 13: a systematic review of randomized controlled trials
Authors: Wang Qian , Lam Lawrence T. , Lin Heng , Yang Wenxian , Ying Fuxian , Li Yongwei 
Published: August 2024

Abstract

Introduction:
To use a quantitative approach to investigate the effectiveness the randomized controlled trials of family-based intervention programs on objectively measured moderate to vigorous physical activity (MVPA) and sedentary behavior (SB) in children under 13.
Methods
PubMed, Medline, Web of Science and Embase were searched from January 2013 to February 2024. Intervention studies that investigated the effectiveness of family-based interventions on objectively measured MVPA among children under 13 and the randomized controlled trials were included in this meta-analysis. Lastly, subgroup analyses were conducted to explore the potential modifying effects of family-based intervention’s characteristics and study quality.
Results
Ten articles met the inclusion criteria for this review. Studies investigated a range of outcomes, including moderate-to-vigorous intensity physical activity, sedentary behavior and fundamental motor skills. Meta-analysis showed that family intervention had a significant effect on MVPA (WMD = 5.13, 95%CI = 1.09, 9.17, p = 0.01, I2 = 61%; p = 0.006), especially for the fundamental motor skills (WMD = 5.77, 95%CI = 3.87, 7.67, p < 0.00001), but not for SB (WMD=-.1.34, 95%CI=-6.85, 4.18, p = 0.63). Subgroup analyses indicated there was a significant effect in the short-term intervention (WMD = 9.08, 95%CI = 2.54, 15.62, p = 0.007) with heterogeneity results (I2 = 37%; p = 0.19) and in the weekend (SMD = 0.63, 95%CI = 0.33, 0.93, p < 0.0001), with heterogeneity results (I2 = 35%, p = 0.21).
Conclusions
Family-based intervention could be a promising way to promote children’s MVPA, especially for fundamental motor skills. Future researches could be pay more attention to tailored interventions which refer to the funny activities, focus on the fragmented time on weekdays, relate to stay close to nature.
Trial Registration:
Meta-analysis PROSPERO: CRD42023488011
Pulse Rate Variability as a Predictor for Length of Stay for Patients with Bronchiolitis in the Pediatric Intensive Care Unit
Authors: Kwon Soon Bin , Weinerman Bennett , Nametz Daniel , Alalqum Tammam , Lee Isaac S. , Megjhani Murad , McLaren Son H. , Ranard Benjamin , Ku Yunseo , Geneslaw Andrew , Park Soojin 
Published: August 2024

Abstract

Patients admitted to pediatric Intensive Care Unit (PICU) due to bronchiolitis have unpredictable length of stay (LOS). The aim of this study is to observe the difference in the relationship between pulse rate variability (PRV) and heart rate variability (HRV) for patients with bronchiolitis admitted to the PICU and its association with LOS. The first 12 hours of physiologic data after PICU admission were used for analysis. Electrocardiogram (ECG) and photoplethysmography (PPG) were divided into non-overlapping 5-minute segments, and R-peak and PPG-peak were obtained to calculate PRV and HRV. Correlation was calculated between HRV and PRV for each PICU LOS group and was tested with Fisher Z-transformation. The student’s t-test, chi-square test was performed on other independent variables, including age, gender, prematurity and ventilation type. A total of 119 patients were included in this study. For both LOS groups, PRV and HRV parameters were significantly different. However, the correlations between PRV and HRV parameters were significantly higher in the short-stay group compared to the long-stay group. This study demonstrates that the correlation between the PRV and HRV is lower in patients with longer length of stay, suggesting this can be a potential metric for LOS in PICU.
A latent profile analysis of health-related quality of life in patients with aplastic anemia
Authors: Wu Guibin , Li Xiao , Ren Xiang , Huang Jinbo , Zhang Xiaoxiao , Liang Taimei , Sun Lina , Hao Mengmeng , Kuang Zhexiang , Li Xinli , Zhang Qianqian , Xu Li , Zheng Yizhou , Xie Wenjun 
Published: August 2024

Abstract

Background
Concerns over health-related quality of life (HRQOL) in patients with aplastic anemia (AA) have been increasing worldwide. However, most researches on HRQOL in AA patients have ignored individual-level variability. Thus, our study was designed to explore practical classification of HRQOL and related variables among AA patients.
Methods
A cross-sectional study was conducted from May 2022 to March 2023, utilizing convenience sampling to enroll AA patients. Data of HRQOL, sociodemographic characteristics, and clinical variables were collected. Latent profile analysis (LPA) was used to analyze the latent categories of HRQOL in AA patients, utilizing scores from eight subscales of the Medical Outcomes Study 36-Item Short Form Health Survey version 2.0.
Results
A total of 229 patients completed the survey and were included in the analysis. The LPA results showed significantly individual differences and identified three subgroups of HRQOL: Group 1, poor HRQOL with role emotional limitation (n = 54, 23.58%); Group 2, moderate HRQOL with role physical limitation (n = 56, 24.45%), and Group 3, good HRQOL (n = 119, 51.97%), respectively among AA patients. Childless, no comorbidities, transfusion independence, no AA-related symptoms, and higher annual household income were associated with Group 3, whereas higher Eastern Cooperative Oncology Group performance status scores were associated with Group 1.
Conclusions
The findings of our study revealed significant heterogeneity in HRQOL among AA patients, providing valuable information for tailoring interventions to meet individual needs, especially for those in the poor HRQOL with role emotional limitation group.
Survey analysis of a huge number of pesticides in the sold medicinal plants under uncontrolled practices using both LC-MS/MS and GC-MS/MS
Authors: Ismail Marwa M. , Refaat Mohamed , Amer Mohamed , Elhamalawy Osama H. , Allah Hend M. Abd , Taha Sherif M. 
Published: August 2024

Abstract

In developing countries, herbal plants are not only sold under controlled conditions (in markets and pharmacies), but also sold in traditional markets without proper control conditions. For this reason, a total of 120 samples of five different medicinal plants were collected from local markets in three different Egyptian governorates (40 samples for each governorate), and the presence of a wide range of pesticides residues was tested. The collected samples were extracted and cleaned up by an accredited analytical method, based on the known QuEChERS extraction approach and using GC-MS/MS and LC-MS/MS. Results revealed that 63 pesticide residues were found in samples collected from three different governorates. Notably, more than fifteen pesticides were detected in eight samples. Furthermore, chlorpyrifos was the most frequently detected pesticide. Additionally, thiophanate-methyl had the highest concentration with a concentration of 5.65 mg kg-1, followed by malathion with a concentration of 2.55 mg kg-1, both of which were detected in Cairo Governorate. In conclusion, these results not only indicate the presence of uncontrolled pesticide practices in herbal agriculture production but also suggest the existence of an uncontrolled import of highly contaminated herbs. Furthermore, a probability of pesticide treatments during their storage stage may be occurred in the uncontrolled local traditional market.
The effects of physical exercise, parent-child interaction and peer relationship on adolescent depression: an empirical nalysis based on CEPS data
Authors: Lang Li , Kexin Ren , Bingbing Fan 
Published: August 2024

Abstract

Currently, depression is the predominant mental illness impacting adolescents, causing severe damage to their overall health. Engaging in physical exercise can not only aid in restoring adolescent physical well-being but also function as a strategy to prevent depression and lower suicide rates. Drawing upon data from the China Education Panel Survey (CEPS) conducted between 2014 and 2015, this study delves into the effects of physical exercise on alleviating depressive symptoms among adolescent students and explores the underlying mechanisms through the lens of parent-child interactions and peer relationships. The mediation effect tests indicate that physical exercise can mitigate adolescent depression by reinforcing parent-child bonds and improving peer connections. Parents and educational institutions should judiciously plan the time for adolescents to engage in both academic pursuits and physical activities, and they should encourage greater participation in sports among adolescents through various means, thereby maximizing the beneficial role of physical exercise in ameliorating adolescent depression.
Risk assessment of landslides induced by the Ms6.2 earthquake in Jishishan of Gansu province, China
Authors: HAO WANG , Quanfu Niu , Xi'an Cheng , Gang Wang 
Published: August 2024

Abstract

2023-12-18T23:59, an earthquake measuring Ms6.2 occurred in Jishishan County, China, causing serious casualties and directly leading to the occurrence of a large number of landslides. After the earthquake, multiple aftershocks increased the risk of collapse and landslides. Based on high-resolution satellite images before and after the earthquake, a Maximum Entropy model was constructed using visually interpreted landslide points and impact factors characteristics to evaluate the risk of landslide disasters after the earthquake. The conclusions of the study are as follows: 1) The main distribution of earthquake-induced landslide disasters is in the elevation zone of 1800-2300m, on sunny slopes with a slope gradient of 20–25°, which are mostly developed in the area 1.5 km away from the roads, 1.7 km away from the fault zones, and 5 km away from the earthquake center. The majority of the landslide occurred in cropland and loam areas with higher population density in the earthquake region. 2) Based on the contribution rate and replacement importance of the impact factors, test gain value, AUC value, and regularized training gain value, the main impact factors for landslide risk induced by the earthquake were comprehensively determined as follows: Distance from the fault zone, Elevation, and Population density. 3) Based on the constructed Maximum Entropy model, it is found that there is a good consistency between the extremely high and high risk areas of landslide disasters in the earthquake zone and the seismic intensity. Among them, the extremely high and high risk areas are mainly distributed in the intensity zone VIII, with an area of 5.368km2, accounting for 77.82% of the total area of the extremely high and high-risk zones. The low and very low risk areas are mainly distributed in the intensity zones VI and VII, accounting for 92.80% of the total area of the study region. This paper constructs a Maximum Entropy model based on the analysis of the importance of impact factors to evaluate the risk of landslide disasters in the earthquake zone. The research results provide references for post-disaster reconstruction in the earthquake zone.
Modeling NPP and NDVI time series in different bioclimatic regions of Iran
Authors: Sayedzadeh Fahimeh , Soltani Saied , modarres reza 
Published: August 2024

Abstract

Vegetation is one of the important components of ecosystems that usually changes seasonally. An accurate parameterization of vegetation cover dynamics by developing time series models can strengthen our understanding of vegetation change. This research is aims to investigate and model the temporal changes of Net Primary Production (NPP) and Normalized Difference Vegetation Index (NDVI) across bioclimatic regions of Iran, including the Khazari, Baluchi, semi-desert, steppe, semi-steppe and Arid forests. We used Moderate Resolution Imaging Spectroradiometer (MODIS) sensor products for NPP and NDVI time series (MOD17A2 and MOD13Q1, respectively). The SARIMA (Seasonal Autoregressive Integrated Moving Average) time series model is developed for NPP and NDVI time series. The investigation of Auto Correlation Functions (ACF) showed a strong seasonality in NPP and NDVI at the 12-month lag time. Comparing the lag times from 1 to 24 month for different regions shows that the NPP variable has a stronger seasonality. The evaluation of error criteria showed NPP time series models based on RMSE, R2, MRE, and CE criteria was better, while based on the ME criteria, the models performs better for NDVI time series (For example, in Khazari region for NPP and NDVI time series respectively, ME = 3.67, 0.05, RMSE = 0.12, 0.18, R2 = 0.87, 0.63, MRE = 0.02, 0.12, and CE = 0.84, 0.12). The selected models provided a short-term forecasting of the NPP and NDVI index for study regions at 24-month time, that useful for the planning and management to reduce vegetation degradation and preserve ecosystem and biodiversity.
Experiences and Challenges Faced by Nurses in Traumatic Wound Care in the Emergency Department: A Systematic and Comprehensive Review
Authors: ÖZTAŞ ismail , yava ayla , öztaş sevgi 
Published: August 2024

Abstract

Aim: In this article, we aimed to contribute to the scientific community by highlighting the challenges and experiences of nurses in wound care in emergency department
Background: Although there are many studies related to wound care, a literature review reveals that there is no research similar to our article. Therefore, our study is anticipated to serve as a source for future research
Introduction: This study is a systematic review that compiles recent evidence regarding nurses' experiences and various situations encountered in traumatic wound care in emergency departments.
Methods: Data collection was conducted by searching the databases (PubMed, Google Scholar, Science Direct, Cochrane, TurkMedline, and Ulakbim) using the keywords "Traumatic wound care in the emergency department, nurse experience in wound care in the emergency department, challenges experienced in wound care management in the emergency department." The final search was conducted on February 9, 2024
Results: This review included 10 studies. Various recommendations and strategies for traumatic wound care and its aftermath have been outlined. The results of the included studies emphasize the challenging and stressful nature of traumatic wound care, highlighting the need for staff support, specialized preparation for traumatic wound care, necessary equipment, and training to overcome these challenges. Overall, the findings suggest that comprehensive strategies should be developed for both pre- and post-traumatic wound care based on the information provided by these studies.
Discussion: While there are numerous studies on wound care in emergency departments, there is a scarcity of guidance on effective strategies specifically tailored to traumatic wound care. Evidence suggests that addressing and prioritizing multifaceted approaches are crucial for both nurses and patients in traumatic wound care. Further research is needed to provide robust evidence for effective interventions aimed at reducing nurses' distress during and after traumatic wound care.
Conclusion and Implications for Nursing and Health Policy: Traumatic wound care is a critical issue in emergency departments where nurses face significant challenges. Through this systematic review, the results of many studies have been synthesized to identify necessary actions and provide recommendations
RETRACTED: The Future of Biofuel Sustainability: Lipid Production in Microbial Strains Explored by GC-MS Technique
Authors: Chaudhary Ayushi , Tripathi Kanchan Lata , Kumar Devendra , Badoni Himani , pokhriyal Ruby , Verma Nitika 
Published: August 2024

Abstract

The authors have requested that this preprint be removed from Research Square.
Anticoagulation management for veno-venous ECMO in COVID-19 patients: argatroban as rescue therapy in heparin-associated thrombocytopenia
Authors: Schiavoni Lorenzo , Mattei Alessia , Cuccarelli Martina , Strumia Alessandro , Nenna Antonio , Aceto Jessica , Pascarella Giuseppe , Costa Fabio , Cataldo Rita , Agrò Felice Eugenio , Carassiti Massimiliano 
Published: August 2024

Abstract

Background Extracorporeal Membrane Oxygenation (ECMO) has been widely used in the treatment of COVID-19 acute respiratory distress syndrome. The use of anticoagulation during ECMO support remains a topic of debate. The primary aim of this study is to demonstrate the safety and efficacy of using argatroban as an anticoagulant instead of heparin in patients with heparin-associated thrombocytopenia.Methods Forty patients were enrolled and initially treated with unfractionated heparin for anticoagulation during ECMO composing the UFH group. Twenty-one of these patients experienced a drop in platelet count to below 100,000 cells/mm3, tested negative for IgG anti PF4/Heparin, and anticoagulation was switched to argatroban composing the ARG group. Hemorrhagic events were recorded along with blood chemistry parameters.Results Bleedings were significantly more frequent in UFH group than in ARG group (58/401 days vs 21/648 days). No significant differences were observed in hemorrhagic episodes for each bleeding site, except for tracheal stoma. No differences in activated partial thromboplastin time (aPTT) values were found between the two groups. Linear regression analysis revealed that the platelet count on day 5 was correlated with the initial platelet count but not with the type of anticoagulant used. Linear regression analysis in both groups showed a correlation between the duration of ECMO support and intensive care unit stay for median aPTT and median platelet count. Furthermore, no major systemic thrombotic events or circuit clotting were observed in this patient cohort.Conclusions Argatroban seems to be safe in patients with persistent heparin-associated thrombocytopenia undergoing ECMO.
Patients with hemophilia or LQTS: strong improvement needed for both accurate registration of contraindications and in patient understanding of the risks of over-the-counter drugs
Authors: Middeldorp Anniek , Meer Douwe van der , Smit Jaap Jan , de Waal Tim , Egmond Pleun van , Wieringa André 
Published: August 2024

Abstract

Purpose Certain medications are contraindicated in patients with hemophilia or Long QT Syndrome (LQTS). Accurate registration of contraindications in electronic health record (EHR) systems is essential to minimize the risks when prescribing medication by healthcare professionals. Also, the use of certain over-the-counter (OTC) medications is contraindicated in these patients. Hence, patients must be cognizant of the potential risks associated when using these medications. We aimed to quantify the accurate registration of hemophilia and LQTS within primary and secondary care and to assess the degree to which patients take into account their medical condition when visiting healthcare professionals and using over-the-counter medication.
Methods Patients with hemophilia or LQTS being under treatment in Isala Hospital were included. Community pharmacists and General Practitioners (GPs) were surveyed regarding the accurate documentation of these conditions. An analysis was conducted on the prescribed medications for these patients over the past year, to determine if any were contraindicated. Additionally, patients were surveyed to assess their awareness of the medication safety risks of their medical condition.
Results Of the included 32 patients with hemophilia and 21 patients with LQTS the contraindications were accurately registered by pharmacists, GPs and hospital in 86.4, 70.8 and 0% (hemophilia), and 80.0, 82.4 and 28.6% (LQTS), respectively. The majority of patients reported their disease when visiting healthcare professionals. However, of the patients with hemophilia and LQTS 20% and 40%, respectively, were unaware of the potential risks associated with OTC medication.
Conclusion This study indicates that strong improvement can be achieved in accurate registration of the contraindications LQTS and hemophilia in both primary and secondary care. Enhanced registration will improve medication safety in patients when prescribed by healthcare professionals. Additionally, there is a need for increased patient education concerning medication usage, as they tend to underestimate the risks associated with (OTC) medications.
Distinguishing Lymphoma from Benign Lymph Node Diseases in Fever of Unknown Origin using PET/CT Radiomics
Authors: Zhang Xinchao , Jing Fenglian , Hu Yujing , Tian Congna , Zhang Jianyang , Li Shuheng , Wei Qiang , Li Kang , Zheng Lu , Liu Jiale , Zhang Jingjie , Bian Yanzhu 
Published: August 2024

Abstract

Background A considerable portion of patients with fever of unknown origin (FUO) present concomitant lymphadenopathy. Diseases within the spectrum of FUO accompanied by lymphadenopathy include lymphoma, infections, and rheumatic diseases. Particularly, lymphoma has emerged as the most prevalent etiology of FUO with associated lymphadenopathy. However, conventional imaging techniques, including PET/CT, often struggle to accurately distinguish between malignant and benign lymph node lesions. This study utilizes PET/CT radiomics to differentiate between malignant and benign lymph node lesions in patients with FUO, aiming to improve the accuracy of diagnosing lymphoma and benign lymph node diseases.
Results Data were collected from 204 patients who underwent 18F-FDG PET/CT examinations for FUO, including 114 lymphoma patients and 90 patients with benign lymph node lesions. Patients were randomly divided into training and testing groups at a ratio of 7:3. A total of 15 effective features were obtained by the least absolute shrinkage and selection operator (LASSO) algorithm. Machine learning models were constructed using logistic regression (LR), support vector machine (SVM), random forest (RF), and k-nearest neighbors (KNN) algorithms. In the training group, the AUC values for predicting benign and malignant cases by LR, SVM, RF, and KNN models were 0.936, 0.930, 0.998, and 0.938, respectively. There were statistically significant differences in AUC between the RF and other models (all P < 0.001). In the testing group, the AUC values for the four models were 0.860, 0.866, 0.915, and 0.891, respectively, with no statistically significant differences found between the four models (all P > 0.05). The DCA curves of the RF model outperformed those of the other three models in both the training and testing groups.
Conclusions PET/CT radiomics demonstrates promising performance in discriminating lymphoma from benign lymph node lesions in patients with FUO, with the RF model showing the best performance in distinguishing between lymphoma and benign lymph node diseases.