bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long‐term efficacy and safety of zotarolimus‐eluting stent in patients with diabetes mellitus: Pooled 5‐year results from the ENDEAVOR III and IV trials
Authors: Vardi Moshe , Burke David A. , Bangalore Sripal , Pencina Michael J. , Mauri Laura , Kandzari David E. , Leon Martin B. , Cutlip Donald E. 
Published: June 2013

ObjectiveTo assess long‐term outcomes of Endeavor Zotarolimus‐eluting stent (E‐ZES) implantation in patients with diabetes mellitus (DM). Background: Patients with DM and coronary artery disease have lower restenosis with drug‐eluting stent (DES) compared with bare‐metal stents. Recent data suggest that the E‐ZES is inferior to other DES in this population.MethodsPatient‐level data for 601 patients with DM from the ENDEAVOR III and ENDEAVOR IV trials were pooled, of which 337 were treated with E‐ZES and 264 were treated with other DES. The primary outcome was target vessel failure (TVF) in the course of 5 years. Outcomes are reported as rates using Kaplan–Meier (KM) survival method and differences between E‐ZES and other stent types (sirolimus‐eluting stent or paclitaxel‐eluting stent) were compared using the log‐rank statistic. The independent effect of stent type on TVF was assessed using Cox proportional hazards regression.ResultsBaseline characteristics were similar between the groups. Five‐year TVF KM rate estimate was numerically lower for E‐ZES, but the difference did not reach statistical significance (20.2 vs. 26.9%, P = 0.065). The 5‐year KM rate estimates of major adverse cardiac events (17.7 vs. 26.6%, P = 0.012), death (7.6 vs. 15.0%, P = 0.004), and myocardial infarction (1.3 vs. 5.1%, P = 0.011) were also lower for E‐ZES versus other DES. Conclusions: Patients with DM implanted with E‐ZES have favorable long‐term outcomes compared to first‐generation DES. Long‐term performance of DES should be assessed routinely and may differ from initial performance. © 2013 Wiley Periodicals, Inc.
Diagnostic accuracy of intravascular ultrasound‐derived minimal lumen area compared with fractional flow reserve—Meta‐analysis: Pooled accuracy of IVUS luminal area versus FFR
Authors: Nascimento Bruno R. , de Sousa Marcos R. , Koo Bon‐Kwon , Samady Habib , Bezerra Hiram G. , Ribeiro Antônio L.P. , Costa Marco A. 
Published: June 2013

IntroductionAlthough intravascular ultrasound minimal luminal area (IVUS‐MLA) is one of many anatomic determinants of lesion severity, it has been proposed as an alternative to fractional flow reserve (FFR) to assess severity of coronary artery disease.ObjectivePool the diagnostic performance of IVUS‐MLA and determine its overall accuracy to predict the functional significance of coronary disease using FFR (0.75 or 0.80) as the gold standard.MethodsStudies comparing IVUS and FFR to establish the best MLA cutoff value that correlates with significant coronary stenosis were reviewed from a Medline search using the terms “fractional flow reserve” and “ultrasound.” DerSimonian Laird method was applied to obtain pooled accuracy.ResultsEleven clinical trials, including two left main (LM) trials (total N = 1,759 patients, 1,953 lesions) were included. The weighted overall mean MLA cutoff was 2.61 mm2 in non‐LM trials and 5.35 mm2 in LM trials. For non‐LM lesions, the pooled sensitivity of MLA was 0.79 (95% CI = 0.76–0.83) and specificity was 0.65 (95% CI = 0.62–0.67). Positive likelihood ratio (LR) was 2.26 (95% CI = 1.98–2.57) and LR− was 0.32 (95% CI = 0.24–0.44). Area under the summary receiver operator curve for all trials was 0.848. Pooled LM trials had better accuracy: sensitivity = 0.90, specificity = 0.90, LR+ = 8.79, and LR− = 0.120.ConclusionGiven its limited pooled accuracy, IVUS‐MLA's impact on clinical decision in this scenario is low and may lead to misclassification in up to 20% of the lesions. Pooled analysis points toward lower MLA cutoffs than the ones used in current practice. © 2013 Wiley Periodicals, Inc.
Reversibility Analysis for Design Optimization of an Internally Heat‐Integrated Distillation Column
Authors: Xu L. , Yuan X. , Chen D. , Luo Y. , Yu K. 
Published: June 2013

AbstractInternally heat‐integrated distillation columns (HIDiCs) need heat transfer between the two column sections. Intermediate condensing and reboiling of the rectifying and stripping sections favor the reversibility of the separation process and lead to the increase of heat loads for the two sections but the heat transfer to cover the heat load is costly and generates major difficulties in design. A higher number of stages can reduce the heat load but will also raise the investment cost. The influence of increasing stage numbers on operating cost and capital investment of the HIDiC was evaluated by two HIDiC design cases, and the stage numbers or equivalently the heat loads were optimized to achieve the balance between the two kinds of cost.
Resource‐Efficient Process Technology for Energy Plants
Authors: Both Simon , Helling Christoph , Namyslo Jan , Kaufmann Dieter , Rother Beate , Harling Hinrich , Strube Jochen 
Published: June 2013

AbstractIn recent years, a change from the fossil resources coal, oil, and gas to renewable energy sources is underway, whereby biomass from energy plants gains importance. In Germany, this biomass is mainly produced from corn, rape, and further cereals. A study is presented which focuses on the extraction and purification of selective components as a dual‐use concept besides energy production from biomass. A total conceptual process design is laid out, considering the current constraints for biomass use. As an example, the variation of the raw materials as well as the stability of the ingredients and limitations in solvent use can be named. A process is proposed which shows the extraction to be technically and economically feasible.
Störprozesse in organischen Solarzellen
Authors: Walter Christof , Krämer Veronika , Settels Volker , Engels Bernd 
Published: June 2013

AbstractSeit längerem wird organischen Halbleitern für optoelektronische Anwendungen eine große Zukunft vorhergesagt. Während es einige Produkte gibt, die Marktreife erlangt haben, z.B. OLEDs, lässt der Durchbruch in der Photovoltaik noch auf sich warten. Dies hat unter anderem mit Störprozessen zu tun.
Nanopartikel für theranostische Anwendungen
Authors: Sowik Thomas , Hiersch Luisa , Schatzschneider Ulrich 
Published: June 2013

AbstractNanomaterialien begegnen uns heute im Alltag als Zusätze in Hygieneprodukten, Verpackungsmaterialen und sogar Lebensmitteln. Doch auch für medizinische Anwendungen haben sie ein großes Potential, das unter dem Begriff Nanomedizin zusammengefasst wird.
Master Materialchemie
Authors: Kickelbick Guido , Betke Ulf 
Published: June 2013

AbstractGerade in kleinen und mittelständischen Unternehmen nimmt die Nachfrage nach Chemikern mit materialwissenschaftlichem Hintergrund und Materialwissenschaftlern mit chemischen Kenntnissen stetig zu. Im stark interdisziplinär ausgerichteten Masterstudiengang Materialchemie an der Universität des Saarlandes wird dieser Nachfrage Rechnung getragen. Durch die Kombination von natur‐ und ingenieurwissenschaftlichen Lehrveranstaltungen wird eine Verzahnung von Kenntnissen der Synthese und Eigenschaften von Molekülen mit der Denkweise von Ingenieuren erreicht.
Heat transfer and flow characteristics of nanofluid in a narrow annulus: Numerical study, modelling and optimisation
Authors: Bahiraei Mehdi , Hosseinalipour Seyed Mostafa , Hangi Morteza 
Published: June 2013

AbstractThis study attempts to evaluate the flow and heat transfer characteristics of water–Al2O3 nanofluid in a narrow annulus. The effects of volume fraction, the size of particles and the ratio of inner wall heat flux to outer wall heat flux were investigated on the convective heat transfer coefficients and friction coefficients at inner and outer walls of the annulus. Using smaller particles caused a greater heat transfer coefficient. Meanwhile, at higher volume fractions, changing the size of particles led to more considerable changes in the convective heat transfer coefficient and friction coefficient. As per the observation made, the value of heat transfer coefficient at the inner wall was larger than that of the outer wall. In contrast with the results of applying constant properties, changing the volume fraction will change the friction coefficient in the case of using variable properties. Moreover, genetic algorithm was used in combination with compromise programming in order to find the optimum values of the input parameters using neural network correlation.
Recurrence of high‐risk bladder cancer: A population‐based analysis
Authors: Chamie Karim , Litwin Mark S. , Bassett Jeffrey C. , Daskivich Timothy J. , Lai Julie , Hanley Jan M. , Konety Badrinath R. , Saigal Christopher S. ,   the Urologic Diseases in America Project
Published: June 2013

BACKGROUNDPatients with bladder cancer are apt to develop multiple recurrences that require intervention. The recurrence, progression, and bladder cancer–related mortality rates were examined in a cohort of individuals with high‐grade non–muscle‐invasive bladder cancer.METHODSUsing linked Surveillance, Epidemiology, and End Results (SEER)‐Medicare data, subjects were identified who had a diagnosis of high‐grade, non–muscle‐invasive disease in 1992 to 2002 and who were followed until 2007. Multivariate competing‐risks regression analyses were then used to examine recurrence, progression, and bladder cancer–related mortality rates.RESULTSOf 7410 subjects, 2897 (39.1%) experienced a recurrence without progression, 2449 (33.0%) experienced disease progression, of whom 981 succumbed to bladder cancer. Using competing‐risks regression analysis, the 10‐year recurrence, progression, and bladder cancer–related mortality rates were found to be 74.3%, 33.3%, and 12.3%, respectively. Stage T1 was the only variable associated with a higher rate of recurrence. Women, black race, undifferentiated grade, and stage Tis and T1 were associated with a higher risk of progression and mortality. Advanced age (≥ 70) was associated with a higher risk of bladder cancer–related mortality.CONCLUSIONSNearly three‐fourths of patients diagnosed with high‐risk bladder cancer will recur, progress, or die within 10 years of their diagnosis. Even though most patients do not die of bladder cancer, the vast majority endures the morbidity of recurrence and progression of their cancer. Increasing efforts should be made to offer patients intravesical therapy with the goal of minimizing the incidence of recurrences. Furthermore, the high recurrence rate seen during the first 2 years of diagnosis warrants an intense surveillance schedule. Cancer 2013;119:3219–3227. © 2013 American Cancer Society.
The Applicability of a Seminal Professional Development Theory to Creative Arts Therapies Students
Authors: Orkibi Hod 
Published: June 2013

The purpose of this mixed‐methods study was to test the extent to which a seminal theory of the professional development of counsellors and therapists is applicable to the particular experiences of creative arts therapies graduate students who learn how to use the arts in psychotherapy. Nevertheless, readers may consider the results of the present study transferable to other healthcare disciplines. Questionnaires for each developmental phase were used for data collection, and analysis included data quantification, assessment of inter‐rater agreement and theory derivation procedure. Results indicate that creative arts therapies students were concerned about translating theory into practice, learning how experienced therapists concretely function in practice, and reducing cognitive dissonance upon realization that their pre‐training lay conceptions of helping were no longer valid. Stress and anxiety drove students to adopt easily mastered techniques that were implemented creatively in practicum. The results confirm that students who were older and had undergraduate human‐service education and/or considerable life experience were less concerned about their suitability to the profession, were more acquainted with a professional working style and searched for their individual way of becoming therapists. Finally, recommendations for future research are suggested, and implications for practice are offered. Copyright © 2013 John Wiley & Sons, Ltd.Key Practitioner MessageThe study tested the applicability of a seminal theory of the professional development of counsellors and therapists to creative arts therapies students.Students were concerned about reducing cognitive dissonance upon realization that their pre‐training lay conceptions of helping were no longer valid.Stress and anxiety drove students to adopt easily mastered techniques that were implemented creatively in practicum.Older students, with previous human‐service education or considerable life experience, were more certain about their suitability to the profession.
Psychotropic Drug Treatment in Anorexia Nervosa. Search for Differences in Efficacy/Tolerability Between Adolescent and Mixed‐age Population
Authors: Balestrieri Matteo , Oriani Maria Ginevra , Simoncini Annalisa , Bellantuono Cesario 
Published: June 2013

AbstractBackgroundDuring the last 10 years, the use of psychotropic medications in youth with psychiatric disorders, including eating disorders, has significantly increased, but their role in the treatment of adolescent anorexia nervosa is still controversial.ObjectiveThis paper aims to review the literature on the use of antidepressants and antipsychotics in adolescents with anorexia nervosa, comparing the efficacy and tolerability in this population with those reported in trials with patients not selected by age.MethodA systematic review of the available literature published so far.ResultsOnly few studies met the selection criteria. No strong evidence of beneficial effects was found in using antidepressants and antipsychotics neither in adults nor in adolescents. Side effects were more frequently reported in studies including adolescent population.Among psychotropic drugs, the majority of studies focused on olanzapine, which seems to have, in some studies, only positive effects on body mass index, eating disorder symptoms and functional impairment in both age groups. Copyright © 2013 John Wiley & Sons, Ltd and Eating Disorders Association.
Endoscope‐assisted frenotomy approach to median upper neck masses: Clinical outcomes and safety (from a phase II clinical trial)
Authors: Woo Seung Hoon , Jeong Han‐Sin , Kim Jin Pyeong , Park Jung Je , Baek Chung‐Hwan 
Published: June 2013

AbstractBackgroundAn endoscope‐assisted frenotomy approach (EFA) to resection of the median upper neck mass has been introduced to clinical practice. However, its technical feasibility, indications, and safety have not been fully studied. Here, we report the results of a prospective phase II clinical trial to evaluate the clinical outcomes.MethodsTwenty patients were enrolled in this trial. The masses were divided into 3 subtypes. We implemented EFA to remove the masses after receiving informed patient consent. We evaluated the clinical outcomes and complications related to this procedure for more than a 2‐year period.ResultsEFA successfully removed the masses in all cases without any injuries to adjacent nerves or ducts. During the more than 2‐year follow‐up period, recurrence or revision surgeries were not required.ConclusionEFA can be a very effective and safe approach for median upper neck masses, and can also lead to excellent cosmetic and functional results. © 2013 Wiley Periodicals, Inc. Head Neck 36: 985–991, 2014
Cervical metastases from squamous cell carcinoma of hard palate and maxillary alveolus: A retrospective study of 10 years
Authors: Yang Zinan , Deng Runzhi , Sun Guowen , Huang Xiaofeng , Tang Enyi 
Published: June 2013

AbstractBackgroundThe purpose of this study was to investigate the incidence of cervical metastasis in squamous cell carcinoma (SCC) of hard palate and maxillary alveolus and to define its impact factors.MethodsWe conducted a retrospective study of patients surgically treated for SCC of hard palate and maxillary alveolus from 2002 to 2011. In situ hybridization was performed to detect high‐risk human papillomavirus (HPV) infection.ResultsThe incidences of cervical metastasis and occult metastasis were 17.2% (11/64) and 9.8% (5/51), respectively. The pT classification and vascular invasion were correlated with cervical metastasis. Occult metastatic risk was significantly higher among patients with pT4. Presence of positive nodes impaired prognosis significantly.ConclusionSCC of hard palate and maxillary alveolus has nonnegligible incidences of both overall and occult metastasis, which were highly associated with pT classification. We recommend routine, synchronous elective neck dissection for T4 lesions, whereas observation is an alternative for T1 to T3 lesions. © 2013 Wiley Periodicals, Inc. Head Neck 36: 969–975, 2014
Novel utilization of 3D technology and the hybrid operating theatre: Peri‐operative assessment of posterior sterno‐clavicular dislocation using cone beam CT
Authors: Crowhurst James A. , Campbell Douglas , Whitby Mark , Pathmanathan Pavthrun 
Published: June 2013

AbstractA patient with a medial and posterior dislocation of the right sterno‐clavicular (SC) joint and displacement of the trachea and brachiocephalic artery by the medial head of the clavicle underwent general anaesthetic in the operating theatre for an open reduction procedure. The surgeon initially attempted a closed reduction, but this required imaging to check SC alignment. The patient was transferred to an adjacent hybrid operating theatre for imaging. Cone beam computed tomography (CBCT) was performed, which successfully demonstrated a significant reduction in the dislocation of the SC joint. The trachea and brachiocephalic artery were no longer compressed or displaced. This case study demonstrates an alternative to the patient being transferred to the medical imaging department for multi‐slice CT. It also describes a novel use of the hybrid operating theatre and its CBCT capabilities.
μFEA successfully exhibits higher stresses and strains in microdamaged regions of whole vertebrae
Authors: Herblum Ryan , Beek Maarten , Whyne Cari M 
Published: June 2013

ABSTRACTMicro‐finite element (μFE) modeling has shown promise in evaluating the structural integrity of trabecular bone. Histologic microcrack analyses have been compared to μFE models of trabecular bone cores to demonstrate the potential of this technique. To date this has not been achieved in whole bone structures, and comparisons of histologic microcrack and μFE results have been limited due to challenges in alignment of 2D sections with 3D data sets. The goal of this study was to ascertain if image registration can facilitate determination of a relationship between stresses and strains generated from μFE models of whole vertebrae and histologically identified microdamage. μFE models of three whole vertebrae, stained sequentially with calcein and fuchsin, were generated with accurate integration of element sets representing the histologic sections based on volumetric image registration. Displacement boundary conditions were applied to the μFE models based on registration of loaded and unloaded μCT images. Histologically labeled damaged regions were found to have significantly higher von Mises stresses and principle strains in the μFE models, as compared to undamaged regions. This work provides a new robust method for generating and histologically validating μFE models of whole bones that can represent trabecular damage resulting from complex physiologic loading. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1653–1660, 2013
Is there a “July effect” for head and neck cancer surgery?
Authors: Hennessey Patrick T. , Francis Howard W. , Gourin Christine G. 
Published: June 2013

Objectives/HypothesisA “July effect” of increased complications when new trainees begin residency has been reported widely by the media. We sought to determine the effect of admission month on in‐hospital mortality, complications, length of hospitalization, and costs for patients undergoing head and neck cancer (HNCA) surgery.Study DesignRetrospective cross‐sectional study.MethodsDischarge data from the Nationwide Inpatient Sample for 48,263 patients who underwent an ablative procedure for a malignant oral cavity, laryngeal, hypopharyngeal, or oropharyngeal neoplasm in 2005 to 2008 were analyzed using cross‐tabulations and multivariate regression modeling.ResultsThere were 3,812 cases admitted in July (8%). July admission was significantly associated with Medicaid (RRR 1.40, P = 0.011) or self‐pay payor status (RRR 1.40, P = 0.022), medium hospital bed size (RRR 1.63, P = 0.033) and large hospital bed size (RRR 1.73, P = 0.013). There was no association between July admission and other patient or hospital demographic characteristics. Major procedures and comorbidity were significantly associated with in‐hospital death, surgical and medical complications, length of hospitalization, and costs, but no association was found for July admission, July through September discharge, or teaching hospital status and short‐term morbidity or mortality. Teaching hospitals and large hospital bed size were predictors of increased length of hospitalization and costs; and private, for profit hospitals were additionally associated with increased costs. No interaction between July admission and teaching hospitals was found for any of the outcome variables studied.ConclusionsThese data do not support evidence of a “July effect” or an increase in morbidity or mortality at teaching hospitals providing HNCA surgical care.Level of Evidence2c. Laryngoscope, 123:1889–1895, 2013
Er:YAG Laser Activation of Sodium Hypochlorite for Root Canal Soft Tissue Dissolution
Authors: Kuhn Katharina , Rudolph Heike , Luthardt Ralph G. , Stock Karl , Diebolder Rolf , Hibst Raimund 
Published: June 2013

AbstractBackground and ObjectiveThe aim of this in vitro study was to investigate the effect of Er:YAG laser irradiation on the ability of sodium hypochlorite (NaOCl) to dissolve soft tissue during endodontic procedures.Materials and MethodsTwo acrylic glass plates, each containing a semi‐canal, were bolted together to form a complete canal. This geometry permitted one semi‐canal to be filled with fine liver sausage of bovine origin dyed by methylene blue and the other with NaOCl (4.00–4.99% available chlorine; Sigma–Aldrich Corporation, St. Louis, MA), which was then activated by Er:YAG laser irradiation (KEY Laser 3; KaVo, Biberach, Germany) using a plain‐ended fiber tip and a range of output energy and repetition rate. To achieve relatively low output energy from high input energy, the laser beam was attenuated by placing glass slides in the beam path. The resultant images acquired were analyzed using pixel‐based analysis. Samples were statistically analyzed (two‐way ANOVA, P < 0.05, univariate, bifactorial; IBM SPSS Statistics 19, SPSS Inc., Chicago, IL).ResultsBoth output energy and repetition rate significantly influenced the tissue dissolution ability of NaOCl (P < 0.05).ConclusionWithin the limitations of this in vitro study, we conclude that laser activation of NaOCl at 200 mW output power leads to effective soft tissue dissolution. This finding can be of use to endodontists pursuing effective soft tissue dissolution from their irrigants. Lasers Surg. Med. 45:339–344, 2013. © 2013 Wiley Periodicals, Inc.