bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solid Phase Extraction – Voltammetric Coupled Detection of Caffeine in Acetonitrile
Authors: Chan Kwok K. , Webster Richard D. 
Published: August 2015

AbstractCaffeine (CAF) in aqueous solutions was extracted into acetonitrile (MeCN) using solid phase extraction (SPE). The voltammetric detection of CAF in MeCN was performed in a microcentrifuge tube after SPE in order to minimise the required amount of MeCN and reagents used during the analysis. The voltammetric determination of CAF from a range of beverages extracted into MeCN was in good agreement with the results obtained from HPLC measurements on the same samples. The SPE‐coupled voltammetric method gave more accurate results than those obtained via the direct voltammetric detection of CAF in real beverage samples.
Eating Disorders and Problematic Eating Behaviours Before and After Bariatric Surgery: Characterization, Assessment and Association with Treatment Outcomes
Authors: Conceição Eva M. , Utzinger Linsey M. , Pisetsky Emily M. 
Published: August 2015

AbstractAccumulating evidence suggests that bariatric surgery candidates are likely to present with eating disorders (EDs) and/or problematic eating behaviours (EBs), and research suggests that these problems may persist or develop after bariatric surgery. While there is growing evidence indicating that EDs and EBs may impact bariatric surgery outcomes, the definitions and assessment methods used lack consensus, and findings have been mixed. The aims of this paper were (1) to summarize the existing literature on pre‐operative and post‐operative EDs and problematic EBs; (2) to discuss the terms, definitions and assessment measures used across studies; and (3) to consider the extent to which the presence of these problems impact surgery outcomes. We highlight the importance of investigators utilizing consistent definitions and assessment methodologies across studies. © 2015 The Authors. European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd.
Depression and Personality Traits Associated With Emotion Dysregulation: Correlates of Suicide Attempts in Women with Bulimia Nervosa
Authors: Pisetsky Emily M. , Wonderlich Stephen A. , Crosby Ross D. , Peterson Carol B. , Mitchell James E. , Engel Scott G. , Joiner Thomas E. , Bardone‐Cone Anna , Le Grange Daniel , Klein Marjorie H. , Crow Scott J. 
Published: August 2015

AbstractObjectiveThe objective of this study was to identify personality traits and psychiatric comorbidities associated with a lifetime history of a suicide attempt in women with bulimia nervosa (BN).MethodData from two samples of women with BN (n = 204 and n = 133) were examined. Participants in both samples completed the Dimensional Assessment of Personality Pathology—Basic Questionnaire and reported whether they had ever had a lifetime suicide attempt. Comorbid psychopathology was based on self‐reported questionnaire and interview data. Univariate and multivariate logistic regression analyses were run, predicting a lifetime suicide attempt.ResultsBased on the Dimensional Assessment of Personality Pathology—Basic Questionnaire, identity problems were associated with a lifetime suicide attempt in both samples; cognitive dysregulation, anxiousness and insecure attachment were associated with a lifetime suicide attempt in one but not both samples. Lifetime anxiety disorder was associated with a lifetime suicide attempt in one sample, and depression was associated with a lifetime suicide attempt in both samples. Multivariate analyses revealed that only depression was uniquely associated with a lifetime suicide attempt in both samples.DiscussionAlthough personality traits associated with aspects of emotion dysregulation were associated with a lifetime suicide attempt, depression was found to have the strongest association with a lifetime suicide attempt in two samples of women with BN. These findings suggest that depression severity may be the most important target of treatment and suicide prevention efforts in women with BN. Copyright © 2015 John Wiley & Sons, Ltd and Eating Disorders Association.
On generalized crystal‐plasticity based on defect‐densities in a second‐order continuum
Authors: Steinmann Paul 
Published: August 2015

AbstractSingle crystals display various defects that may potentially act as obstacles to further evolution of inelastic deformations, i.e. to further plastic flow. These are translational defects in terms of dislocations, rotational defects in terms of disclinations, and (dilatational) pointdefects in terms of lattice vacancies or interstitial atoms. A formulation of generalized crystalplasticity is proposed that incorporates the densities of these defects in order to capture the hardening of the material. In particular the inclusion of the defect densities other than the dislocation density requires to root the formulation in a second‐order continuum description. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Synchronous parotid and nasopharyngeal Warthin tumor
Authors: Ory Madgar , Eran Alon 
Published: August 2015

AbstractBackgroundWarthin tumor is the second most common benign salivary gland neoplasm after pleomorphic adenoma. Warthin tumors occur almost exclusively in the parotid gland and periparotid lymph nodes, extraparotid localization is rare.Methods and ResultsWe describe a case of a patient presenting with a synchronous unilateral parotid gland and nasopharyngeal Warthin tumor.ConclusionWe propose that, although this occurrence of a synchronous parotid gland and nasopharyngeal Warthin tumor may be coincidental, it is more likely to be an effect of a systemic factor. © 2015 Wiley Periodicals, Inc. Head Neck 38: E71–E72, 2016
Trends in treatment and survival for advanced laryngeal cancer: A 20‐year population‐based study in The Netherlands
Authors: Timmermans Adriana J. , van Dijk Boukje A. C. , Overbeek Lucy I. H. , van Velthuysen Marie‐Louise F. , van Tinteren Harm , Hilgers Frans J. M. , van den Brekel Michiel W. M. 
Published: August 2015

AbstractBackgroundThe purpose of this study was to determine time trends for primary treatment modalities in advanced laryngeal cancer, overall survival (OS), and laryngectomy‐free interval (LFI) over the last 2 decades in The Netherlands.MethodsWe conducted an analysis of T3 to T4 laryngeal cancer data from 2 combined national (population‐based and pathology‐based) cancer registries.ResultsA total of 2072 T3 cases (14.7%) and 1722 T4 cases (12.2%) were identified. Total laryngectomy as primary treatment modality decreased, whereas radiotherapy (RT) increased. For T3 disease, 5‐year OS after primary total laryngectomy (+/− adjuvant RT), RT, and chemoradiotherapy (CRT) was 49%, 47%, and 45%, respectively. For T4 disease, this was 48%, 34%, and 42% (overall p < .0001), respectively. Five‐year LFI for T3 disease was 81% (RT) and 77% (CRT), and for T4 disease it was 81% and 87%, respectively.ConclusionFrom 1991 to 2010 total laryngectomy as primary treatment modality for advanced laryngeal cancer decreased and RT increased. T3 disease showed similar survival rates for all primary treatment modalities. For T4 disease, total laryngectomy (+ adjuvant RT) showed the best survival. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1247–E1255, 2016
Association between helicobacter pylori infection and carcinoma of the larynx or pharynx
Authors: Zhou Jian , Zhang Duo , Yang Yue , Zhou Liang , Tao Lei 
Published: August 2015

AbstractBackgroundInfection with Helicobacter pylori (H. pylori) plays a role in the development of gastric carcinoma. However, there is controversy as to whether H. pylori infection increases laryngeal or pharyngeal cancers.MethodsWe managed a systematic review of researches related to H. pylori infection in laryngeal or pharyngeal carcinomas, distributed up to December 2014. Odds ratios (ORs) and 95% confidence intervals (CIs) were assessed by random effects models or according to heterogeneity I2.ResultsEleven studies were involved in the meta‐analysis. Overall, H. pylori infection was significantly higher in the study group compared with the normal control group (OR = 2.87; 95% CI = 1.71–4.84; I2 = 67.1; p < .0001, random effects analysis). The ORs for laryngeal carcinoma were 3.28 (95% CI = 1.91–5.63; I2 = 58; p < .0001, random effects model). The ORs for pharyngeal cancer were 1.35 (95% CI = 0.86–2.12; p = .188, random effects model).ConclusionThis study supported the proposition that infection with H. pylori was related to laryngeal carcinoma, specifically in the hospital‐based control group and diagnosed by polymerase chain reaction (PCR) or enzyme‐linked immunosorbent assay (ELISA). Nevertheless, no significant relationship was discovered between H. pylori infection and pharyngeal cancer. © 2015 Wiley Periodicals, Inc. Head Neck 38: E2291–E2296, 2016
MicroRNA‐200 promotes lung cancer cell growth through FOG2‐independent AKT activation
Authors: Guo Lixia , Wang Jingyu , Yang Ping , Lu Qiang , Zhang Ting , Yang Yanan 
Published: August 2015

AbstractMicroRNA‐200 (miR‐200) has emerged as a regulator of the PI3K/AKT pathway and cancer cell growth. It was reported that miR‐200 can activate PI3K/AKT by targeting FOG2 (friend of GATA 2), which directly binds to the p85α regulatory subunit of PI3K. We found that miR‐200 was elevated in early stage lung adenocarcinomas when compared with normal lung tissues, and the expression of miR‐200 promoted the tumor spheroid growth of lung adenocarcinoma cells. We show that AKT activation was essential for such oncogenic action of miR‐200. However, depletion of FOG2 had little effect on AKT activation. By performing a reverse‐phase protein array, we found that miR‐200 not only activated AKT but also concomitantly inactivated S6K and increased IRS‐1, an S6K substrate that is increased on S6K inactivation. Depletion of IRS‐1 partially inhibited the miR‐200‐dependent AKT activation. Taken together, our results suggest that miR‐200 may activate AKT in lung adenocarcinoma cells through a FOG2‐independent mechanism involving IRS‐1. Our findings also provide evidence that increased miR‐200 expression may contribute to early lung tumorigenesis and that AKT inhibitors may be useful for the treatment of miR‐200‐dependent tumor cell growth. © 2015 IUBMB Life, 67(9):720–725, 2015
Vesicular trafficking and salinity responses in plants
Authors: Baral Anirban , Shruthi K. S. , Mathew M. K. 
Published: August 2015

AbstractResearch spanning three decades has demonstrated that vesicles pinch off from the plasma membrane and traffic through the cytoplasm of plant cells, much as previously reported in animal cells. Although the well‐conserved clathrin‐mediated mechanism of endocytosis has been well characterized, relatively little is known about clathrin‐independent pathways in plants. Modulation of endocytosis by both physical stimuli and chemical ligands has been reported in plants. Here, we review the effect of salinity—one of the most deleterious environmental assaults—on endocytosis and intracellular trafficking. © 2015 IUBMB Life, 67(9):677–686, 2015
The role of placenta‐derived mesenchymal stem cells in healing of induced full‐thickness skin wound in a mouse model
Authors: Abd‐Allah Somia H. , El‐Shal Amal S. , Shalaby Sally M. , Abd‐Elbary Eman , Mazen Nehad F. , Abdel Kader Rania R. 
Published: August 2015

AbstractWe examined the effect of placenta‐derived MSCs (PDMSCs) injection intraregionally and intraperitoneally on healing of induced full thickness mice skin wounds; moreover, the mechanisms by which MSCs exert their effects were also studied. Sixty female mice were divided into three groups after induction of full thickness skin wound; untreated group, wounded mice were injected with MSCs derived from human placenta intraperitoneally or intraregionally. Skin biopsies were obtained 7 and 12 days after wound incision for histological examinations, detection of vascular endothelial growth factor (VEGF) by ELISA, and estimation of expression of mouse ICAM‐1, Integrin β1, Integrin β3 genes and human albumin and GAPDH genes by reverse transcription polymerase chain reaction. Human placenta derived‐MSCs treated groups showed accelerated wound healing than non‐treated group. VEGF, Integrin β1, and Integrin β3 levels were significantly increased in the intraregionally and intraperitoneally treated mice as compared to non‐treated group at day 7 after wound induction. ICAM‐1 showed significant decrease in its expression in treated groups compared with non‐treated group. Interestingly, the intraperitoneal MSCs injections showed better results than intraregional one. PDMSCs accelerate full thickness skin wound healing and the intraperitoneal MSCs injections are more effective than intraregional one. MSCs promote wound healing through release of proangiogenic factors as VEGF, increase healing promoting factors as integrin β1 and β3, and decrease proinflammatory cytokines as ICAM‐1. © 2015 IUBMB Life, 67(9):701–709, 2015
Applying OntoREM to a Space Mission: Developing Requirements for the MASCOT Lander
Authors: Antonini Kelly , Lange Caroline , Kossmann Mario , Odeh Mohammed 
Published: August 2015

AbstractOntoREM is an Ontology‐driven Requirements Engineering Methodology supported by software tooling, developed jointly by UWE and Airbus. OntoREM has been tested using a number of pilot cases in various domains at Airbus. In this research, OntoREM is applied to a space mission called MASCOT (Mobile Space Asteroid Scout) developed by DLR (Deutsches Zentrum für Luft‐ und Raumfahrt), Germany, together with CNES (Centre National d'Etudes Spatiales), France, and the Japanese Space Agency (JAXA). The research provided the opportunity to carry out a comparative critical evaluation of the outcomes of the application of OntoREM to MASCOT versus the outcomes of a more traditional Systems Engineering approach as applied by DLR‐Bremen. The key objective was to generate an alternative set of MASCOT requirements using OntoREM based on the existing set of MASCOT system requirements, and to compare the quality of the resulting requirements with the quality of the existing requirements in terms of correctness, completeness and consistency. The application of OntoREM to MASCOT has been successful, it appears that OntoREM is suitable for the development of requirements for space mission programmes and creates quality improvements when generating requirement specifications. About 100% additional project and system requirements were identified, while a re‐usable MASCOT project domain ontology was built during the process that may be generalised for future lander missions.
TOPASE: Tools for Operability Assessment and Support Enhancement for life cycle system performance optimisation
Authors: DUCAMP Christophe , Elegbede Charles 
Published: August 2015

AbstractIn this paper, the authors propose a methodology to optimize the overall system performances like the availability and the cost of a system subject to availability, cost and common cause failure constraints. The system to be optimized consists of n components and for each component, there are many suppliers which propose their offers, so one has to choose the best combination for the n components to design the system. The problem is NP‐hard and is also (discrete) multi‐objective optimization problem. The model is based on the Markovian assumption, and a genetic algorithm is used to solve this combinatorial problem in a reasonable computing time.
A risk based view on building a sustainable nuclear electricity industry in South Africa
Authors: Fick JIJ , Stoker PW 
Published: August 2015

AbstractThis paper introduces a Nuclear Sustainability Risk Model, which reflects a proposed strategy for ensuring the sustainability of a nuclear electricity industry for South African in the long term. The model is used to illustrate the interrelationships between economic, engineering and social considerations.The strategy employed in this paper considers the risks from a systems thinking approach. This strategy is derived based on reviews performed on the lessons learnt from South African projects, Medupi and Kusile, and of recent nuclear power plant constructions internationally. Although the South African study is not nuclear specific, it is performed to obtain a better understanding of some of the regional and national challenges for major plant constructions that would require mitigation strategies. The lessons learnt from these projects were consolidated and related to a possible nuclear new build program terms of potential risks. The risks identified are categorized as higher level risks that affect the integrity of the model and seen as country wide issues that would affect major plant constructions in South Africa (macroeconomic risks) and medium term strategic project risks which could or would directly affect the anticipated outcome of a nuclear construction program in South Africa.The identified risks and areas for consideration are explained and the potential mitigation strategies are proposed.
Addressing large national problems in South Africa
Authors: Gonçalves Duarte P. 
Published: August 2015

AbstractThis paper seeks to create a methodology to address large national problems based on the author's experiences on border security and rhino poaching in South Africa. Five problem aspects of large national problems are identified: one or more States, multiple organisations and the general public are involved; problems evolve; the simultaneity of intervention; the issue of complexity and dualism as an example of a frame or worldview. A transdisciplinary approach is proposed as an integrating framework that could deal with complexity. Based on this, a number of areas of systems engineering as problem solving have been extended to deal with border security and rhino poaching: foresight (future problem), operating concept, stakeholder engagement and legal analysis. Finally, the implications for tailoring of a process or methodology are outlined and changes to INCOSE's definition of systems engineering are proposed.
A Systematic Method for the Development of a Functional Safety Concept
Authors: Neitzel Karl Ernst , Kaffenberger Rüdiger 
Published: August 2015

AbstractThe comfort we gain from our passenger cars is very much offset by the dangers to our climate caused by the energy consumption and exhaust of the cars. Complex electronic controls in the cars can reduce the energy consumption but raise the probability of dangerous unwanted behaviour. The requirements of ISO 26262 on the design of safety related functionality shall reduce these dangers. We present the architecture and design principles of our functional safety concept, that fulfils the requirements of ISO 26262 as well as the requirements of our platform concept for systems engineering work products. The key enabler for the design and maintenance of our functional safety concept are distinct views we employ to show important aspects of the set of safety requirements.
Architecture‐driven Design Study Of An Electrically‐Powered UAV
Authors: Lemmens Y. , Dehandschutter W. , Olbrechts T. , Becuwe I. 
Published: August 2015

AbstractAn architecture‐driven design process, enabled by tools for system synthesis, simulation, and simulation content management, can be used to efficiently explore design variants at a system level. A case study is presented where this is successfully applied to an electrical system of an unmanned aerial vehicle. In this case, different combinations of electrical motors and propellers were investigated and different types of cooling of the fuselage.
Subsea Oil Production The Design Basis
Authors: Piciaccia Luca A. 
Published: August 2015

AbstractThe origination of the Design Basis document for subsea production systems (SPS) in the oil industry is a challenging task. The completeness and correctness of the Design Basis is crucial for the successful execution of the project in safety, technical and commercial terms.This work aims to establish, through the use of Systems Engineering and specifically throughInformation Models (Model Based Systems Engineering), how the Subsea Production System Design Basis should be optimally developed. The MBSE is integrated in this work by the theory of Transactional Processing, which is implicit in the universal thought process when behavioural models are drafted but seldom explicitly referred to.The current industry practice for developing an SPS design basis is compared to the suggested optimal process.The work constitutes the foundation for the revised Design Basis issuing procedure and the Design Review practice for the Aker Solutions worldwide subsea business.This work is part of a PhD at the Norwegian Technology and Science University.
Ontology‐driven Semantic Search for Requirement Engineering
Authors: Piciaccia Luca A. , Croce Danilo , Basili Roberto , Storch Valerio 
Published: August 2015

AbstractRequirement elicitation is a challenge in the Subsea Oil extraction industry due to the short project award and execution times that do not allow the complete compilation of a requirement database from the contract documents and appendixes. In this paper, a semantic approach to the automation of relevant inferences involved in the Requirement Analysis (RA) stages is proposed. An ontological model is here proposed to supporting the enrichment of the involved texts along a number of semantic assumptions, aiming to provide a rich explanatory description of the targeted phenomena These general types are used to enable the semantic annotation of texts and sentences within the documentation, i.e. conceptual information useful to characterize design choices (as in specification documents), requirements (design documents) or product descriptions (catalogues). A Machine learning approach is then discussed as a robust and effective solution to annotated texts according to the ontological model.
Structuring Requirements in Standard Templates
Authors: Beasley Richard , Cardow Iain , Hartley Michael , Pickard Andrew 
Published: August 2015

AbstractA survey of the contents of various Requirements and Definition Documents both within Rolls‐Royce and in the literature revealed a large variety of structures and contents. Many requirements documents do not distinguish in their structure between functional and the various non‐functional requirements but mix these up within the content of the requirements structure.The authors have proposed a generic rationalized structure for capturing and recording requirements, and have illustrated this with gas turbine engine examples. The authors have also proposed a parallel structure for Definition Documents, where there is even more variation in content in the literature examples, and have illustrated this again with gas turbine engine examples.
The Life Cycle of a Requirement
Authors: Sparrius Ad 
Published: August 2015

AbstractThis paper investigates the life cycle of a requirement. The life cycle of a requirement is modelled, and its implications on design‐to requirements, build‐to requirements and as‐built characteristics pursued. Validation and verification, and all its many instances, are examined in considerable detail by means of a validation/verification model. The concept of endorsement is introduced. Traceability and various trace instances are discussed. The results have been formalized into a set of principles. A detailed example is investigated.