bluuebunny/crossref_metadata_2025_split huggingface dataset:
The silicon vacancy centers in SiC: determination of intrinsic spin dynamics for integrated quantum photonics
Authors: Liu Di , Kaiser Florian , Bushmakin Vladislav , Hesselmeier Erik , Steidl Timo , Ohshima Takeshi , Son Nguyen Tien , Ul-Hassan Jawad , Soykal Öney O. , Wrachtrup Jörg 
Published: July 2024

AbstractThe negatively charged silicon vacancy center ($${{\rm{V}}}_{{\rm{Si}}}^{-}$$

V

Si

−

) in silicon carbide (SiC) is an emerging color center for quantum technology covering quantum sensing, communication, and computing. Yet, limited information currently available on the internal spin-optical dynamics of these color centers prevents us from achieving the optimal operation conditions and reaching the maximum performance especially when integrated within quantum photonics. Here, we establish all the relevant intrinsic spin dynamics of the $${{\rm{V}}}_{{\rm{Si}}}^{-}$$

V

Si

−

center at cubic lattice site (V2) in 4H-SiC by an in-depth electronic fine structure modeling including the intersystem-crossing and deshelving mechanisms. With carefully designed spin-dependent measurements, we obtain all the previously unknown spin-selective radiative and non-radiative decay rates. To showcase the relevance of our work for integrated quantum photonics, we use the obtained rates to propose a realistic implementation of time-bin entangled multi-photon GHZ and cluster state generation. We find that up to three-photon GHZ or cluster states are readily within reach using the existing nanophotonic cavity technology.
Nanoliposomal irinotecan with fluorouracil and folinic acid, FOLFIRINOX, and S-1 as second-line treatment for unresectable pancreatic cancer after gemcitabine/nab-paclitaxel
Authors: Shibuki Taro , Otsuka Taiga , Shimokawa Mototsugu , Nakazawa Junichi , Arima Shiho , Fukahori Masaru , Miwa Keisuke , Okabe Yoshinobu , Koga Futa , Ueda Yujiro , Kubotsu Yoshihito , Makiyama Akitaka , Shimokawa Hozumi , Takeshita Shigeyuki , Nishikawa Kazuo , Komori Azusa , Otsu Satoshi , Hosokawa Ayumu , Sakai Tatsunori , Oda Hisanobu , Kawahira Machiko , Arita Shuji , Honda Takuya , Taguchi Hiroki , Tsuneyoshi Kengo , Kawaguchi Yasunori , Fujita Toshihiro , Sakae Takahiro , Nio Kenta , Ide Yasushi , Ureshino Norio , Shirakawa Tsuyoshi , Mizuta Toshihiko , Mitsugi Kenji 
Published: July 2024

AbstractThis study aimed to compare second-line treatment outcomes for patients with unresectable pancreatic cancer previously treated with gemcitabine plus nab–paclitaxel (GnP) therapy. We conducted an integrated analysis of two retrospective studies included 318 patients receiving nanoliposomal irinotecan + 5-fluorouracil/folinic acid (NFF) (n = 102), S-1 (n = 57), or FOLFIRINOX (n = 14) as second-line treatment. Median overall survival (OS) in the NFF group was 9.08 months, significantly better than S-1 (4.90 months, P = 0.002). FOLFIRINOX had a median OS of 4.77 months, not statistically different from NFF. Subgroup analyses of OS indicated NFF was generally superior, however, a statistical interaction was observed between the treatment regimen in serum Alb < 3.5 g/dL (P = 0.042) and serum CRP ≥ 0.3 mg/dL (P = 0.006). Median progression-free survival (PFS) was 2.93 months for NFF, significantly better than S-1 (2.53 months, P = 0.024), while FOLFIRINOX had a comparable PFS (3.04 months, P = 0.948). Multivariate analysis identified the serum CRP, serum CA19-9, duration of first-line GnP therapy, and use (yes/no) of S-1 for second-line treatment as independent predictors for OS. This study concludes that second-line NFF therapy demonstrated a more favorable OS compared to S-1 therapy, however, it is still important to consider the patient background characteristics while selecting the most appropriate treatment.
Role of Nannochloropsis Oculata supplement in improving performance, antioxidant status, blood metabolites, and egg quality of laying hens under hot environmental conditions
Authors: Emam K. R. S. , Ali Safaa A. M. , Morsy A. S. , Fouda Wafaa A. , Elbaz Ahmed M. 
Published: July 2024

AbstractThe increase in environmental temperature led to economic losses in the poultry industry, urging the use of feed supplements to mitigate the negative effects on chick's welfare and performance. Therefore, this study aimed to examine the effects of marine microalgae (Nannochloropsis Oculata, N. Oculata) additive on commercial Brown Lohmann laying hen's performance, blood metabolites, and antioxidant status under hot environmental conditions. One hundred and eighty birds (34 weeks old with an initial body weight of 1885 ± 23.5 g) were used till 47 weeks. The birds were divided into three equal groups (birds in each group were distributed into four equal replicates 15 hens/ replicate). The 1st group was the control (CON) and was fed the basal diet, while the 2nd (TR1) and 3rd (TR2) groups were fed the basal diet supplemented with 0.5 and 1.0% of N. Oculata, respectively. The results showed that total protein and globulin concentrations increased (P < 0.05) in treated groups compared with the control group, whereas, albumin concentration increased (P < 0.05) in TR2 compared to the control group. The concentration of ALT and AST decreased in hens fed N. Oculata. Supplementing with N. Oculata reduced serum cholesterol and creatinine concentrations, while glucose concentration increased (P < 0.05) in the treated groups compared to the control group. Serum calcium, total antioxidant capacity (TAC), Triiodothyronine (T3), and progesterone increased (P < 0.05) in hens fed N. Oculata. N. Oculata supplement improved production performance through a positive effect on egg number, egg weight, egg mass, feed conversion ratio, and mortality rate. In addition, the overall mean of shell thickness increased (P < 0.05) in hens fed N. Oculata. It can be concluded that the supplementation of 1.0% N. Oculata to the laying hens' diet enhanced productive performance, serum constituents, and antioxidant status under hot environmental conditions.
Shale pore characteristics and their impact on the gas-bearing properties of the Longmaxi Formation in the Luzhou area
Authors: Li Jing , Li Hu , Jiang Wei , Cai Molun , He Jia , Wang Qiang , Li Dingyuan 
Published: July 2024

AbstractDeep shale has the characteristics of large burial depth, rapid changes in reservoir properties, complex pore types and structures, and unstable production. The whole-rock X-ray diffraction (XRD) analysis, reservoir physical property parameter testing, scanning electron microscopy (SEM) analysis, high-pressure mercury intrusion testing, CO2 adsorption experimentation, and low-temperature nitrogen adsorption–desorption testing were performed to study the pore structure characteristics of marine shale reservoirs in the southern Sichuan Basin. The results show that the deep shale of the Wufeng Formation Longyi1 sub-member in the Luzhou area is superior to that of the Weiyuan area in terms of factors controlling shale gas enrichment, such as organic matter abundance, physical properties, gas-bearing properties, and shale reservoir thickness. SEM is utilized to identify six types of pores (mainly organic matter pores). The porosities of the pyrobitumen pores reach 21.04–31.65%, while the porosities of the solid kerogen pores, siliceous mineral dissolution pores, and carbonate dissolution pores are low at 0.48–1.80%. The pores of shale reservoirs are mainly micropores and mesopores, with a small amount of macropores. The total pore volume ranges from 22.0 to 36.40 μL/g, with an average of 27.46 μL/g, the total pore specific surface area ranges from 34.27 to 50.39 m2/g, with an average of 41.12 m2/g. The pore volume and specific surface area of deep shale gas are positively correlated with TOC content, siliceous minerals, and clay minerals. The key period for shale gas enrichment, which matches the evolution process of shale hydrocarbon generation, reservoir capacity, and direct and indirect cap rocks, is from the Middle to Late Triassic to the present. Areas with late structural uplift, small uplift amplitude, and high formation pressure coefficient characteristics favor preserving shale gas with high gas content and production levels.
A randomised controlled trial of plasma exchange compared to standard of care in the treatment of severe COVID-19 infection (COVIPLEX)
Authors: Arulkumaran Nishkantha , Thomas Mari , Stubbs Matthew , Prasanna Nithya , Subhan Maryam , Singh Deepak , Ambler Gareth , Waller Alessia , Singer Mervyn , Brealey David , Scully Marie 
Published: July 2024

AbstractCOVID-19 disease is associated with a hyperinflammatory, pro-thrombotic state and a high mortality. Our primary objective was to assess the change in inflammatory and thrombotic markers associated with PEX, and secondary objectives were to assess the effects of PEX on progression of respiratory failure and incidence of acute thrombotic events. We conducted a prospective, phase II, non-blinded randomised control trial of plasma exchange compared to standard of care in critically ill adults with severe COVID-19 associated respiratory failure, requiring supplemental oxygen or ventilatory support and elevated thrombo-inflammatory markers (LDH, CRP, ferritin, and D-Dimer). Patients randomised to receive PEX were treated with a daily single volume plasma exchange for a minimum of five days. Twenty-two patients were randomised of who 11 received PEX. Demographic and clinical characteristics were similar between groups at presentation. PEX was associated with a significant reduction in pro-thrombotic markers FVIII, VWF and VWF Ag: ADAMTS 13 ratio (p < 0.001). There were no differences in the reduction of inflammatory markers, severity of respiratory failure (p = 0.7), thrombotic events (p = 0.67), or mortality (p > 0.99) at 28 days. PEX successfully reduced pro-thrombotic markers, although was not associated with reduction in inflammatory markers, respiratory failure, or thrombotic events.Trial registration: (NCT04623255); first posted on 10/11/2020.
Ameliorative effects of sildenafil against carbon tetrachloride induced hepatic fibrosis in rat model through downregulation of osteopontin gene expression
Authors: Nasr Hend Elsayed , Hegazy Ahmed Medhat , El-Shaer Noha Osama , El-shafey Rabab Shaban , Elgendy Salwa A. , Elnoury Heba A. , Gazzar Walaa Bayoumie El , Mohammed Lina Abdelhady 
Published: July 2024

AbstractThe liver carries out many essential tasks, such as synthesising cholesterol, controlling the body’s storage of glycogen, and detoxifying metabolites, in addition to performing, and regulating homeostasis. Hepatic fibrosis is a pathological state characterized by over accumulation of extracellular matrix (ECM) including collagen fibers. Sildenafil (a selective inhibitor of type 5 phosphodiesterase) has anti-inflammatory, antioxidant and anti-apoptotic properties. It is commonly used to treat erectile dysfunction in male. The purpose of the current investigation was to evaluate sildenafil’s hepatoprotective potential against liver fibrosis in rats that was caused by carbon tetrachloride (CCl4). Liver enzymes and oxidative markers as well as profibrotic genes were determined. The findings showed that sildenafil alleviates the hepatic dysfunctions caused by CCl4 by restoring normal levels of ALT, AST, and GGT as well as by restoring the antioxidant status demonstrated by increased glutathione (GSH), and catalase. In addition, a significantly down-regulated the mRNA expressions of profibrotic genes [collagen-1α, IL-1β, osteopontin (OPN), and transforming growth factor-β (TGF-β)]. Additionally, sildenafil lessens the periportal fibrosis between hepatic lobules, congestion and dilatation in the central vein, and the inflammatory cell infiltrations. As a result, it is hypothesized that sildenafil may be helpful in the management of hepatotoxicity brought on by CCl4 through suppressing OPN.
Novel lytic bacteriophage AhFM11 as an effective therapy against hypervirulent Aeromonas hydrophila
Authors: Muliya Sankappa Nithin , Shivani Kallappa Girisha , Kallihosuru Boregowda Kushala , Mandrira Ramakrishna Namrutha , Kattapuni Suresh Prithvisagar , Shriraje Balakrishna Dheeraj , Ballamoole Krishna Kumar , Thangavel Suresh , Sahoo Lopamudra , Lange Miles D. , Deshotel Michael B. , Abernathy Jason W. 
Published: July 2024

AbstractSeveral farmed fish species, including carps, tilapia, salmon, and catfish, have experienced significant economic losses in aquaculture due to motile Aeromonas septicemia caused by Aeromonas hydrophila. In the present study, a novel lytic bacteriophage infecting hypervirulent Aeromonas hydrophila (vAh) was isolated and characterized. This is the first report of a phage against vAh. Phage AhFM11 demonstrated lytic activity against both vAh strains and the A. hydrophila reference strain ATCC 35654. The AhFM11 genome was sequenced and assembled, comprising 168,243 bp with an average G + C content of 41.5%. The genome did not harbor any antibiotic resistance genes. Genomic information along with transmission electron microscopy revealed that phage AhFM11 belongs to the Straboviridae family. Therapeutic application of monophage AhFM11 in fish showed 100% survival in injection, 95% in immersion and 93% in oral feeding of phage top-coated feed. Fish and chicken meat spiked with A. hydrophila and phage showed significant reduction of A. hydrophila. These findings support that phage AhFM11 can be used as a biocontrol agent against vAh as an alternative to antibiotics.
Differential but complementary roles of HIF-1α and HIF-2α in the regulation of bone homeostasis
Authors: Lee Sun Young , Kim Su-Jin , Park Ka Hyon , Lee Gyuseok , Oh Youngsoo , Ryu Je-Hwang , Huh Yun Hyun 
Published: July 2024

AbstractBone is a highly dynamic tissue undergoing continuous formation and resorption. Here, we investigated differential but complementary roles of hypoxia-inducible factor (HIF)-1α and HIF-2α in regulating bone remodeling. Using RNA-seq analysis, we identified that specific genes involved in regulating osteoblast differentiation were similarly but slightly differently governed by HIF-1α and HIF-2α. We found that increased HIF-1α expression inhibited osteoblast differentiation via inhibiting RUNX2 function by upregulation of Twist2, confirmed using Hif1a conditional knockout (KO) mouse. Ectopic expression of HIF-1α via adenovirus transduction resulted in the increased expression and activity of RANKL, while knockdown of Hif1a expression via siRNA or osteoblast-specific depletion of Hif1a in conditional KO mice had no discernible effect on osteoblast-mediated osteoclast activation. The unexpected outcome was elucidated by the upregulation of HIF-2α upon Hif1a overexpression, providing evidence that Hif2a is a transcriptional target of HIF-1α in regulating RANKL expression, verified through an experiment of HIF-2α knockdown after HIF-1α overexpression. The above results were validated in an ovariectomized- and aging-induced osteoporosis model using Hif1a conditional KO mice. Our findings conclude that HIF-1α plays an important role in regulating bone homeostasis by controlling osteoblast differentiation, and in influencing osteoclast formation through the regulation of RANKL secretion via HIF-2α modulation.
Mitigating density fluctuations in particle-based active nematic simulations
Authors: Kozhukhov Timofey , Loewe Benjamin , Shendruk Tyler N. 
Published: July 2024

AbstractUnderstanding active matter has led to new perspectives on biophysics and non-equilibrium dynamics. However, the development of numerical tools for simulating active fluids capable of incorporating non-trivial boundaries or inclusions has lagged behind. Active particle-based methods, which typically excel at this, suffer from large density fluctuations that affect the dynamics of inclusions. To this end, we advance the Active-Nematic Multi-Particle Collision Dynamics algorithm, a particle-based method for simulating active nematics, by addressing the large density fluctuations that arise from activity. This paper introduces three activity formulations that mitigate the coupling between activity and local density. Local density fluctuations are decreased to a level comparable to the passive limit while retaining active nematic phenomenology and increasing the active turbulence regime four-fold in two dimensions. These developments extend the technique into a flexible tool for modeling active systems, including solutes and inclusions, with broad applications for the study of biophysical systems.
Logic and symbolism of switchable porous framework materials
Authors: Abylgazina Leila , Senkovska Irena , Kaskel Stefan 
Published: July 2024

AbstractMetal-organic frameworks (MOFs) are highly porous materials composed of organic linkers and inorganic nodes. A subset of MOFs can switch between at least two structures differing significantly in porosity, offering new opportunities for application technologies. However, network topology, micromechanics of building blocks and their hinges, particle size, defects, agglomeration etc., are convoluted into the responsiveness of the system. Many factors are a consequence of the material’s history, including synthesis, desolvation, and all subsequent handling steps, leading to a complex interplay of factors difficult to express clearly by ordinary language systems, chemical or mathematical symbols without loss of intuitive understanding. Here, we propose a symbolic language for the rationalization of switchability emphasizing the history-dependent responsivity of many dynamic frameworks and their stimuli-induced phase transitions. The system follows a bivalent logic inspired by Freges “Begriffsschrift”, providing a fundamental logic structure for the rationalization of statements and representation of logic gates.
Visible light induced palladium-catalyzed Suzuki–Miyaura cross-coupling of glycosyl chlorides to form C-aryl glycosides
Authors: Lai Jinsheng , Zhang Yufeng , Zhan Ying , Zhou Zhuoyi , Wang Zhen , Liu Hui , Zhang Qingju , Sun Jian-Song , Wang Liming 
Published: July 2024

A powerful method is developed utilizing excited-state palladium-catalyzed Suzuki–Miyaura reaction to synthesize C-aryl glycosides. It can be applied to a wide range of aryl and heteroaryl boronic ester substrates as well as glycosyl chlorides.
Finite‐time consensus for variable‐order fractional non‐linear multi‐agent systems under actuator faults and external disturbances
Authors: Nazemorroaya Ehsan , Shafieirad Mohsen , Hashemi Mahnaz 
Published: July 2024

AbstractThe present investigation aims to address the leader‐following consensus issue for variable‐order fractional multi‐agent systems (VOFMASs) under actuator faults and unknown external disturbances. The Caputo definition for the variable‐order fractional (VOF) derivative is used to model the non‐linear dynamics of the leader and follower agents. Consequently, two lemmas are developed for the Caputo VOF derivative of the Lyapunov function. In the first case, it is assumed that the multi‐agent system (MAS) operates without actuator faults and an adaptive controller is proposed. With the aid of the developed lemmas, assurance is provided for the finite‐time bounded cooperative tracking of the VOFMAS despite the presence of unknown external disturbances. In the second case, a novel fault‐tolerant controller is designed for the finite‐time consensus of the MAS under two common kinds of actuator faults: loss of effectiveness fault and bias fault. Finally, the efficacy of the proposed controller is demonstrated through the presentation of results from three simulation examples.
2D sectorial dipole‐enabled planar endfire circularly polarized antenna with widened azimuth half‐power beamwidth
Authors: Gu Shan‐Shan , Lu Wen‐Jun , Zhu Lei 
Published: July 2024

AbstractThis letter proposes a novel planar endfire circularly polarized antenna with widened half‐power beamwidth. Widened azimuth beamwidth mechanism of 2D sectorial electric dipole is theoretically revealed, thus it is able to combine with a rectangular magnetic dipole to yield a half‐power beamwidth widened planar endfire circularly polarized antenna. Finally, a prototype planar endfire circularly polarized antenna with sectorial flared angle of α = 270° is fabricated, simulated, and implemented to validate the design approach. As investigated, the antenna exhibits broadened azimuth half‐power beamwidth of 150° over a frequency range of 2.40–2.45 GHz.
The Retinex enhancement algorithm for low‐light intensity image based on improved illumination map
Authors: Weng Ruidi , Zhang Ya , Wu Hanyang , Wang Weiyong , Wang Dongyun 
Published: July 2024

AbstractTaken in low‐light intensity conditions, image with low brightness affects processing precision. In this article, the Gamma Function based on the brightness average and weighted fusion method according to gray entropy is proposed, which is combined with the improved Retinex algorithm. First, the maximum values of R, G, and B channels in original image are extracted to generate the primary illumination map. Second, the illumination map is optimized and adjusted via the Gamma correction function based on the average brightness value. Finally, the illumination map and detail layer are fused by a weighted fusion algorithm of gray entropy to obtain the reflection map. Reflection maps are used as enhancement. The algorithm proposed in this article can improve the brightness and maintain light distribution in the original image with higher precision and less color distortion.
Research on image saliency detection based on deep neural network
Authors: Qiu Linrun , Zhang Dongbo , Hu Yingkun 
Published: July 2024

AbstractAs a hot research field at present, computer vision is devoted to the rapid acquisition and application of target information from images or videos by simulating human visual mechanism. In order to improve the accuracy and efficiency of image detection, image saliency region detection technology has received more and more attention in the field of computer vision research; an important research content in the field, the core part of which lies in the research on algorithms related to feature extraction and saliency calculation of targets. This paper analyzes the multi‐feature fusion saliency detection model and visual saliency calculation process, and based on the existing algorithm, by improving the VGG16 network, a fully convolutional network saliency detection algorithm is proposed. The qualitative and quantitative experimental results show that compared with the four mainstream methods of BL, GS, SF, and RFCN, our algorithm not only improves the accuracy of salient object detection, but also effectively solves the problem of target edge blur. Therefore, this study has improved the accuracy and efficiency of saliency detection, which can not only promote the development of computer vision technology, but also provide support for research in the field of image processing.
An unsupervised coherent receiver digital signal processing algorithm based on spectral clustering with no data preamble
Authors: He Jianhua , Zhan Yueying , Pan Haoyuan , Peng Hui 
Published: July 2024

AbstractA coherent optical receiver digital signal processing (DSP) scheme is proposed based on spectral clustering, which utilises spectral clustering to cluster the signals outputted by the DSP. Compared to existing blind DSP algorithms for coherent optical receivers operating at over 100Gbps with PM‐mQAM, the proposed scheme effectively suppresses various physical impairments, achieving lower bit error rates (BERs) at the same transmission distance, thus enabling longer transmission distances under the same forward error correction threshold. Furthermore, simulations of the proposed scheme on a 14GBaud PM‐16QAM coherent optical transmission system show that, at a BER of 1.9E‐2, the maximum transmission distance increases from 1700 to 2000 km, and at a BER of 3.8E‐3, it increases from 700 to 900 km.