bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple Lentigines (Leopard) Syndrome with Chiara I Malformation
Authors: Agha Amr , Hashimoto Ken 
Published: April 2015

AbstractThis is a case report of multiple lentigines (Leopard Syndrome) with Chiari malformation, i.e. a herniation of the cerebellum into the foramen magnum. This male patient had generalized multiple lentigines since birth, and the lesions spread steadily, involving the scalp but sparing all mucous membranes. Organ system involvements included heart murmur, ocular hypertelorism, and retardation of growth.
Infrequent Expression of Protein p53 in Epidermotropic Variants of Cutaneous T‐Cell Lymphoma
Authors: de Misa Ricardo F. , Azaña José Manuel , Harto Antonio , Bellas Carmen , Ledo Antonio 
Published: April 2015

AbstractAlthough diverse types of lymphomas have been examined for immunohistochemical detection of p53 protein, little information is available with regard to p53 protein expression in CTCL. We analyzed cutaneous biopsy specimens of 22 patients with the diagnoses of mycosis fungoides or Sézary syndrome with polyclonal rabbit anti‐p53 antiserum CM‐1. Staining of neoplastic cells was observed only in two patients with advanced disease. Overexpression of p53 protein does not seem to be a major feature of either mycosis fungoides or Sézary syndrome.
A Case of Lichen Myxedematosus with Clearly Exacerbated Skin Eruptions after UVB Irradiation
Authors: Yamazaki Soji , Fujisawa Takayuki , Yanatori Akihiko , Yamakage Akio 
Published: April 2015

AbstractWe report a 48‐year‐old male with typical lichen myxedematosus, liver dysfunction, and diabetes mellitus. His skin eruptions were clearly exacerbated after accidental over‐irradiation by UVB. These findings were clinically and histologically confirmed. The pathogenesis is still unknown, but we consider it to be due to Koebner phenomenon.
An Autopsy Case of Malignant Lymphoma with Lyell's Syndrome
Authors: Sadi Al Muktafi , Toda Takayoshi , Kiyuna Masaya , Tamamoto Tooru , Ohshiro Kazuiku , Shinzato Rimi 
Published: April 2015

AbstractWe present a case of fatal Lyell's syndrome which developed following a CT examination using omnipaque 3000 contrast medium. A 59‐year‐old man was suffering from malignant lymphoma. He was readmitted to this hospital due to relapse of fever and lymph node swelling. On the day of readmission, generalized erythema, purpura, and mucosal erosions developed after a CT examination. Steroids and chemotherapy were ineffective, and he expired approximately two weeks after admission. Drug‐induced dermatopathy or leukemic cell infiltration in the skin was clinically suspected. Histological findings disclosed toxic epidermal necrolysis.
Erythematous Papules in a Patient with Cardiac Myxoma: A Case Report and Review of the Literature
Authors: Misago Noriyuki , Tanaka Tatsurou , Hoshii Takashi , Suda Hisao , Itoh Tsuyoshi 
Published: April 2015

AbstractA 35‐year‐old woman was followed up by a physician for one and a half years as a case of transient ischemic attack (TIA) due to thrombosis. She had a few erythematous papules on the dorsal side of her right forearm and on the right side of her neck. From the history of TIA and the transient erythematous papules, we suggested the possibility of cardiac myxoma. Echocardiogram demonstrated a large mass in her left atrium. An immediate operation was carried out, and the cardiac myxoma was excised surgically. Histological examination of the erythematous papule revealed myxoma emboli.
In vitro Comparative Study of the Antitumor Effects of Human Interferon‐α, β and γ on the Growth and Invasive Potential of Human Melanoma Cells
Authors: Horikoshi Takashi , Fukuzawa Kumiko , Hanada Nirou , Ezoe Kyori , Eguchi Hiroaki , Hamaoka Shuji , Tsujiya Hidenobu , Tsukamoto Taiji 
Published: April 2015

AbstractWe have studied the effects of interferon (IFN)‐α, β, and γ in vitro on the growth and invasive potential of human melanoma SK‐MEL‐118 cells.The antiproliferative effects of IFNs were assessed by a quantitative regrowth assay in which cells were treated with IFNs at concentrations of 102, 103 or 104 IU/ml for 3 days (until day 4) and then further incubated without IFNs for 7 days (until day 11). The growth inhibitory effect of each IFN on melanoma cells was dose‐ and time‐dependent. Among these three types of IFNs, however, IFN‐β exerted the strongest inhibitory effect on cell growth.To assess the anti‐invasive effect of each IFN on melanoma cells, we employed an in vitro assay system using matrigel‐coated Transwell chambers. When cells were treated with 102, 103, or 104 IU/ml of the three types of IFNs for 24 hours, the amount of tritiated thymidine incorporated into cells generally increased, indicating that cell growth was not inhibited by the pretreatment When melanoma cells were treated for 24 hours with 104 IU/ml of IFN‐β or γ prior to the assay, the number of cells that invaded the filter decreased by 40%; this decrease was only 10% with the same amount of IFN‐α. Simultaneous addition of IFNs during the invasion assay was not effective in any combination. Only when the cells were pretreated with IFNs, antiinvasive effects against melanoma cells were exerted. IFN‐a was less inhibitory than IFN‐β or γ on proliferation and not at all inhibitory on invasion. Considering both the antiproliferative and antiinvasive effects of IFNs, our results suggest that IFN‐β has the strongest antitumoral effect on human melanoma cells. IFN‐γ had a relatively strong inhibitory effect, especially on invasion.
Cytokine Profile of Tumor Cells in Mycosis Fungoides: Successful Treatment with Intra‐lesional Interferon‐γ Combined with Chemotherapy
Authors: Yamamoto Toshiyuki , Sasaki Go , Sato Takahiro , Katayama Ichiro , Nishioka Kiyoshi 
Published: April 2015

AbstractTwo cases of mycosis fungoides (MF) in the tumor stage were treated with intra‐lesional interferon‐γ (IFN‐γ) therapy. After systemic chemotherapy, intra‐lesional recombinant interferon‐γ was applied to the residual tumors. Intra‐lesional IFN‐γ was sufficiently effective in the treatment of MF tumors, especially small‐sized ones. Reverse transcriptase polymerase chain reaction (RT‐PCR) analysis of messenger RNA expression of cytokines commonly detected interleukin‐6 (IL‐6) and IFN‐γ in the tumor cells before intra‐lesional IFN‐γ. However, in our study, tumor cells in these cases did not exhibit the definitive cytokine patterns of Th1 or Th2.
Recurrent Dermatofibrosarcoma Protuberans with Myxoid and Fibrosarcomatous Changes Paralleled by Loss of CD34 Expression
Authors: Sato Noriko , Kimura Keisuke , Tomita Yasushi 
Published: April 2015

AbstractA 38‐year‐old woman complained of recurrent nodules on her anterior chest wall. She noticed the first nodule at the age of 12 and has since undergone surgical removal a total of 31 times. Finally, wide resection of parts of the rib cartilage and sternum and chest wall reconstruction were required. Histopathological examination of a series of surgical specimens were reevaluated. Immunohistochemical staining of the tumors by anti‐CD34 antibody provided a definite diagnosis of dermatofibrosarcoma protuberans (DFSP). A noteworthy result was that her DFSP did not always express CD34; the recurrent tumors with myxoid and fibrosarcomatous changes lost their CD34 expression.
Necrotizing Fasciitis in Association with Hyperimmunoglobulin E Syndrome
Authors: Misago Noriyuki , Tanaka Tatsurou , Takeuchi Minora , Oka Shohki 
Published: April 2015

AbstractA case of necrotizing fasciitis in association with hyperimmunoglobulin E (HIE) syndrome is reported. The patient was a 17‐year‐old Japanese boy with a clinical history of recurrent skin and pulmonary infections and eczematoid dermatitis, markedly elevated serum levels of IgE, and coarse facies. He had a gangrenous swelling on the lower abdominal wall, and his general condition was poor with high fever. The involved site was accompanied by subcutaneous gas; the culture of the pus of the lesion grew anaerobes without mixed growth of Staphylococcus aureus. Exhaustive debridment of necrotic fascia, which extended much farther than the gangrenous area, and administration of antibiotics had a curative effect on the gangrenous soft tissue infection. To the best of the authors' knowledge, this is the first published case of necrotizing fasciitis in association with HIE syndrome.
Nodular Melanoma in 62 Japanese Patients: Influence of Initial Surgical Treatment on Local Recurrence and Prognosis
Authors: Kato Taizo , Suetake Takaki , Kumasaka Naka , Tabata Nobuko , Sugiyama Yasuko , Tagami Hachiro 
Published: April 2015

AbstractThe incidence of malignant melanoma is much lower in Japanese than in Caucasians, and the commonest type of melanoma in Japanese is acral lentiginous melanoma (ALM). In contrast to the improved prognosis noted in ALM, it is now of increasing concern that there is a rise in both the frequency and mortality of nodular melanoma. During the 25 years from 1970 to 1994, we observed 190 patients with melanoma, including 62 nodular melanomas and 96 ALM, at the Department of Dermatology, Tohoku University Hospital, Sendai, Japan. We retrospectively reviewed the recurrence and survival rates of nodular melanoma observed. The proportion of nodular melanoma, once comprising only 24% of all melanomas, showed a sharp increase to 40% after 1982. The anatomical sites of the primary tumor were the hands and feet (29%), extremities excluding hands and feet (27%), head and neck (23%), and trunk (21%). Comparison of the stages of nodular melanoma when diagnosed showed that the proportion of stage III remained highest throughout the whole period, but that of stage II melanomas increased after 1982. After treatment, local recurrence occurred far more frequently in nodular melanoma (19%) than in ALM (1%). The prognosis of nodular melanoma was also less favorable than that of ALM, although it slightly improved after 1982; the 5‐year survival rates before and after 1982 were 34 and 50%, respectively. Twenty‐eight patients with nodular melanoma had underwent simple excision or incisional biopsy of the primary tumor at another institution and were later referred to us for further intensive care or for the treatment of local recurrence and/or metastases. The rate of local recurrence of melanoma in such referred patients was higher than that in those who underwent an initial excision with wide margins in our hospital. Concurrently, the prognosis in the former group was significantly lower than that in the latter group; the 5‐year survival rate for the group of narrow initial margin was 22% in contrast to that of wide margin (56%). Combination therapy including initial surgical excision with wide margins as well as the careful follow‐up apparently result in a better outcome for the Japanese patients with nodular melanoma.
A Comparative Study of Axillar Hair Removal in Women: Plucking versus the Blend Method
Authors: Urushibata Osamu , Kase Kayoko 
Published: April 2015

AbstractFourteen healthy adult Japanese females were selected to participate in a comparative study of hair plucking (a temporary hair removal technique) and the blend method (a permanent hair removal technique). The effectiveness of permanent hair removal and the safety of the blend method were examined in this study. If hairs of the left axilla were removed by the blend method, then hairs of the right axilla were removed by plucking, and vice versa. Every hair was removed and the number of hairs was counted each time. Sessions were conducted every three weeks, and the experiment continued until no new hair growth was seen using the same experimental standard. Electrologists with more than 1000 hours of experience were selected to perform electrolysis. Examinations of the axilla, before and after each test, were conducted by the authors.The results showed that the number of hairs decreased in the axilla with each session using the blend method: permanent hair removal was achieved in an average of 26.8 weeks or 9.9 sessions. However, the number of hairs did not decrease in the axilla after plucking. Also, there were no reports of hair removal related side‐effects in this study. It was thus demonstrated that the blend method is a safe and effective way of achieving permanent hair removal.
Lymphomatoid Papulosis Followed by Ki‐1 Positive Anaplastic Large Cell Lymphoma: Proliferation of a Common T‐Cell Clone
Authors: Amagai Masayuki , Kawakubo Yo , Tsuyuki Akira , Harada Reiko 
Published: April 2015

AbstractWe report a case of lymphomatoid papulosis (LyP) followed by Ki‐1 positive anaplastic large cell lymphoma (LCL). A 33‐year‐old man developed subcutaneous nodules in the left inguinal region and the left thigh after a seven‐year‐history of self‐healing papulonecrotic lesions of LyP. Histological and immunohistochemical examination of the subcutaneous nodules revealed LCL. DNA was isolated from a nodule of the initial stage of LyP in 1988, a subcutaneous nodule of LCL in 1993, and a papule of LyP in 1993 which appeared after chemotherapy for LCL. T cell receptor gene rearrangement analysis demonstrated an identical rearranged pattern in all the three specimens, indicating that a common T cell clone proliferated throughout the course in both the LyP and LCL lesions.
Extensive Lichen Amyloidosus Refractory to DMSO
Authors: Kobayashi Takashi , Yamasaki Yuichiro , Watanabe Tomoo , Onoda Noboru 
Published: April 2015

AbstractWhile lichen amyloidosus reportedly may respond to dimethyl sulfoxide (DMSO) application, we present a patient whose lesions were refractory to this agent. This Japanese woman had chronic extensive lichen amyloidosus, mainly on her trunk. Her 10‐year history of using nylon towels was the suspected cause. The application of DMSO ointment had no clinical effect, and the amyloid deposits persisted in the histological specimens despite the treatment. The administration of a topical corticosteroid led to gradual clinical improvement.
A Case of Atrophoderma of Pasini and Pierini: Analysis of Glycosaminoglycan of the Lesional Skin
Authors: Tajima Shingo , Sakuraoka Kouichi 
Published: April 2015

AbstractWe report a case of atrophoderma of Pasini and Pierini. We determined the glycosaminoglycan content in the involved skin. Dermatan sulfate content in the involved skin (1.88 μg uronic acid/mg dry skin) was greater than that in the uninvolved skin (1.05 μg uronic acid/mg dry skin). No significant differences in hyaluronic acid, chondroitin sulfate or heparan sulfate content between involved and uninvolved skin were observed. These results suggest that abnormal metabolism of dermatan sulfate may be involved in the pathogenesis of atrophoderma; this pattern has been observed in systemic or localized scleroderma.
Dermatofibroma with Myxoid Changes in a Patient with Psoriasis
Authors: Yamamoto Toshiyuki , Yokoyama Akiko , Katayama Ichiro , Nishioka Kiyoshi 
Published: April 2015

AbstractA 38‐year‐old female with psoriatic arthritis developed a dermatofibroma (DF) on her upper arm. Its position was not exactly on a psoriatic plaque; however, psoriatic lesions were present diffusely around the DF lesion. Histological examination revealed the typical features of DF with myxoid changes in the portion between the tumor nest and the overlying epidermis. The mast cell number was significantly increased over that of solitary DFs without myxomatous lesions. It was suggested that mast cells may play a role in induction of the myxoid changes in the DF lesion in this case.
Pustular Psoriasis Precipitated by Acetazolamide
Authors: Kuroda Kei , Kojima Takayuki , Tanabe Emiko , Fujita Masaru , Shinkai Hiroshi 
Published: April 2015

AbstractWe report a case of pustular psoriasis precipitated by acetazolamide, a carbonic anhydrase inhibitor. A 28‐year‐old man suffering from 20 years‐standing generalized pustular psoriasis developed psoriatic arthritis and glaucoma and experienced a precipitation of pustular lesions and widespread erythema after initiation of oral acetazolamide for glaucoma. The cutaneous lesions and systemic symptoms improved after restriction of acetazolamide and administration of oral etretinate. Readministration of acetazolamide confirmed that generalized pustules arose within 24 hours.
Erythemas Associated with Essential Thrombocythemia
Authors: Tsuji Takuo 
Published: April 2015

AbstractTwo cases of erythemas associated with essential thrombocythemia (ET) are reported.Case 1: A 64‐year‐old woman, whose ET had been treated with myebronitol for about 10 years, developed erythematous plaques on her trunk after she stopped taking the medicine.Case 2: A 58‐year‐old man, who had had gallstones and ET, developed annular erythemas on his thighs, arms, and trunk. Operation for the gallstones had no effect on the eruption.In both cases, remission of thrombocythemia induced by myebronitol was associated with the disappearance of these erythemas.
Case Report: Cheilitis Granulomatosa with Periodontitis
Authors: Takeshita Taizo , Koga Tetsuya , Yashima Yutaka 
Published: April 2015

AbstractWe report a case of cheilitis granulomatosa with periodontitis in a 39‐year‐old Japanese man. Biopsy specimens from both areas showed noncaseating epithelioid cell granuloma. Dental examination revealed that the lower left first molar had periodontitis. The lower left first molar was removed, and antibiotics and anti‐inflammatory drugs were administrated. After 2 months of periodontitis therapy, the lips returned to normal size without recurrence and the swelling of the buccal mucosa regressed.
Angiogenesis
Authors: Swerlick Robert A. 
Published: April 2015

AbstractThe formation of new blood vessels, angiogenesis, is a complex process which is central to normal development and homeostasis. However, uncontrolled angiogenesis plays a critical role in both inflammatory and neoplastic disorders. Our understanding of angiogenesis has expanded greatly over the past two decades due to the development of in vivo and in vitro models to study this important process. A variety of cytokines and growth factors have been shown to induce new blood vessel formation in vivo, and in vitro studies have been able to define whether agents have direct or indirect effects upon vascular endothelial cells. Our improved understanding of the mechanisms which regulate angiogenesis has now created important opportunities for the development of new therapies for the treatment of inflammatory and neoplastic skin disease.
Keratinocyte‐derived Cytokines and UVB‐Induced Immunosuppression
Authors: Kondo Seiji , Sauder Daniel N. 
Published: April 2015

AbstractUltraviolet radiation (UVB) in sunlight is known to have multiple effects on the immune system. Evidence suggests that UVB‐induced immunosuppression is mediated in part by immunosuppressive and immunoregulatory cytokines. Our studies have utilized gene‐targeted mutant mice to determine key molecular requirements essential for the development of UVB‐induced immunosuppression. Preliminary results from our laboratory suggest that TNF‐α plays a regulatory role in contact hypersensitivity, but is not a crucial factor for UVB‐induced immunosuppression, and that multiple factors are involved in the induction of UVB mediated immunosuppression.
Prognosis and Clinical Relevance of Recurrent Oral Ulceration in Behçet's Disease
Authors: Bang Dongsik , Hur Won , Lee Eun‐So , Lee Sungnack 
Published: April 2015

AbstractThere is no way of predicting whether a patient with recurrent oral ulcerations (ROU) will develop Behçet's disease (BD). In the absence of a valid laboratory test to exclude BD, such oral ulcerations result in a diagnostic problem when they occur as the sole and earliest manifestation of disease.We assessed the prognosis of ROU by performing prospective evaluations of 67 patients who had only a history of ROU and were registered at the Behçet's Disease Specialty Clinic at Severance Hospital of Yonsei University, Seoul, Korea.Thirty‐five patients (52.2%) developed overt manifestations of BD at an average of 7.7 years after the onset of ROU. The frequency of recurrence was 9.8 times per year in progressive cases.From these results, it appears that highly recurrent ROU is a warning signal for BD. Careful examinations of patients, including their minor symptoms, additional laboratory tests, and regular follow‐ups by physicians are required for proper diagnosis.
The Relationships of Onset and Exacerbation of Pustulosis Palmaris et Plantaris to Smoking and Focal Infections
Authors: Akiyama Tomoko , Seishima Mariko , Watanabe Hisayo , Nakatani Akemi , Mori Shunji , Kitajima Yasuo 
Published: April 2015

AbstractClinical data, including focal infection and habitual cigarette smoking, were obtained from 203 male patients with pustulosis palmaris et plantaris (PPP) (age: 43.3 ± 13.4) and 266 female patients (age: 44.0 ± 13.7) for the 20 years from 1975 through 1994 to evaluate the relationship between the onset or severity of PPP and smoking. Seasonal incidences of onset were also studied. The incidence of onset of PPP symptoms was highest in June, when it is the most humid in Japan, and lowest in December. The most common infectious disease associated with PPP was tonsillitis. The percentages of heavy smoking (more than 20 cigarettes per day) were 74.7% and 32.9% for male and female patients, while those in the normal control population in Japan were 37.2% and 9.8% for males and females. These results suggest that heavy smoking, tonsillitis, and seasonal factors such as high humidity and high temperature may be related to the onset and exacerbation of PPP.
Sebaceous Adenomas, Squamous Cell Carcinoma and Skin Infections in a Patient with Carcinoma of the Colon, Rectum and Bladder
Authors: Abraham Zeev , Glück Zahava , Lahat Nitza , Kinarty Amalia 
Published: April 2015

AbstractSebaceous adenomas and squamous cell carcinoma developed in a male patient in addition to viral, mycotic and bacterial infections, several years after the removal of three malignant tumors from his lower gastrointestinal and urinary tract. Skin tests with trichophytin, candidin, and mixed bacteria were negative. Various aspects regarding cutaneous changes associated with colorectal and bladder carcinomas are discussed.
Late Onset Systemic Lupus Erythematosus Diagnosed in an Elderly Man with Unusual Skin Eruptions and Sudden Death
Authors: Iijima Shigeruko , Takita Takashi , Otsuka Fujio 
Published: April 2015

AbstractA rare case of late onset SLE in an elderly man presented with generalized toxicoderma‐like eruptions. The rash first appeared at age 64 years and was characterized by dark or purplish erythematous eruptions disseminated over the body surface. Histological examination revealed marked liquefaction degeneration and leukocytoclastic vasculitis. Direct immunofluorescence study and serological examination results were suggestive of SLE; however, the patient had no episodes of photosensitivity, malar erythema, or arthralgia. He was diagnosed as having SLE 11 months after his first visit and died suddenly 16 months after onset. Elderly men with SLE can present with unusual clinical manifestations; careful examination of these patients is required to reach a correct diagnosis.
A Case of Sarcoidosis Which Relapsed Twice after Successive Parturitions
Authors: Kishimoto Saburo , Yasuno Hirokazu , Ikada Junji 
Published: April 2015

AbstractA 30‐year‐old Japanese woman relapsed into sarcoidosis after two successive parturitions. The cutaneous lesions consisted of scar sarcoidosis, papular type, nodular type, and subcutaneous nodules with histologically typical “naked tubercles”. Hypergammaglobulinemia, elevation of both serum angiotensin converting enzyme and lysozyme levels, and bilateral hilar lymphadenopathy were found in the acute and subacute stages, and spontaneously returned to normal levels 16 months after the onset. Our case suggests that parturition may trigger the onset of sarcoidosis.