bluuebunny/crossref_metadata_2025_split huggingface dataset:
Another Look at Sosates, The “Jewish Homer”
Authors: Burgess R. W. 
Published: February 2013

Abstract
A late eighth-century Latin translation of a Greek Alexandrian chronograph of the second quarter of the sixth century contains a reference to a Sosates, who is described as a “Jewish Homer” who lived in Alexandria. The first, and most complicated, difficulty with this short entry is determining Sosates’ date, which would seem to be the second quarter of the first century B.C.E. The next difficulty is working out what “Jewish Homer” means. Clues are provided by the Jewish poets Philo, Theodotus, and Ezekiel, who used Greek tragic and epic verse to describe Jewish content including the Old Testament, and by the later tradition of Christian Biblical epic in Greek and Latin, which we know of from the fourth century onwards. These examples suggest that Sosates turned some part of the early books of the Old Testament into Homeric verse.
Jeremiah 7 and Flavius Josephus on the First Jewish War
Authors: Ferda Tucker S. 
Published: February 2013

Abstract
Study of Josephus’ interpretation of the Bible has focused on the paraphrase in Antiquities, but Josephus continued to engage Scripture in his post-biblical history. This article contends that Josephus, like the authors of the synoptic gospels and later Jewish exegetes, saw the events of 66-70 C.E. through the lens of Jeremiah’s temple sermon (7:1-34). The accounts of Jesus ben Ananias and Josephus’ speech before the city walls, among other examples, show recourse to Jeremiah 7.
The Problem of the Theater in Early Judaism
Authors: Jay Jeff 
Published: February 2013

Abstract
Some scholars have characterized Jewish participation in Roman theatrical institutions as a departure from normative Judaism, while others have distinguished Jews in the diaspora, who attend the theaters, from Jews in Palestine, who criticize and reject them. Both of these narratives are inadequate because scholars have failed to analyze the sources in terms of the cultural and discursive dynamics of Roman theater-going in general. Critiques and accommodations of the theater are common among Jews who lived in both the diaspora and Palestine, for the nature of theatrical culture itself provided Jews with opportunities for vigorous dialogical give-and-take under a Roman imperium in which theaters and their shows were of utmost political and social importance.
Olfactory Bulb Volume Changes in Patients with Sinonasal Polyposis: A Magnetic Resonance Imaging Study
Authors: Herzallah Islam R. , Askar Sherif M. , Amer Hazem S. , Ahmed Ayman F. , El‐Anwar Mohammad W. , Eesa Mohamed H. 
Published: February 2013

ObjectivesThe olfactory bulb (OB) is thought to be a plastic structure with highly active afferent neurons. The aim of this study was to evaluate the effect of olfactory deprivation caused by sinonasal polyps on OB volume.Study DesignCross‐sectional study.SettingTertiary university hospital, Department of Otolaryngology.Subjects and MethodsTwenty‐two subjects were included: 11 adult patients with bilateral allergic sinonasal polyposis (patient group) and 11 adult healthy controls (control group). Both study groups were matched for age and sex. OB volumes in all study subjects were evaluated in T2‐weighted coronal MRI images by planimetric manual contouring.ResultsIn the patient group, OB volume measurements ranged from 5.2 to 19.5 mm3 (mean ± SD, 10.14 ± 3.8). In the control group, volume measurements ranged from 35 to 75.8 mm3 (mean ± SD, 47.66 ± 10.75). The difference in OB volumes between patient and control groups was statistically significant (P <. 001).ConclusionOur study highlights the significant reduction in OB volume in patients with bilateral sinonasal polyposis as compared with its volume in healthy controls. Further studies are required to evaluate the impact of OB volume reduction on olfactory recovery postoperatively.
Midconvexity for finite sets
Authors: Tabor Jacek , Tabor Józef , Misztal Krzysztof 
Published: February 2013

Abstract
Let X be a finite subset of a real vector space. We study Jensen-type convexity on subsets of X. In particular for subsets of X, we introduce the definition of X-midconvex sets. We show that such a notion corresponds well to the classical notion of a convex set. Moreover, we prove that a function X-midconvex set is a midconvex hull of all its extremal points. Other analogues of some classical results are also given. At the end we present an algorithmic approach to finding the midconvex hull of a given set.

MSC:26A51, 26B25.
The effect of Psoroptes ovis infestation on ovine epidermal barrier function
Authors: Stoeckli Miriam R , McNeilly Tom N , Frew David , Marr Edward J , Nisbet Alasdair J , van den Broek Adri HM , Burgess Stewart TG 
Published: February 2013

AbstractSheep scab is an intensively pruritic, exudative and allergic dermatitis of sheep caused by the ectoparasitic mitePsoroptes ovis. The purpose of the present study was to investigate the effect ofP. ovisinfestation on different components of the ovine epidermal barrier within the first 24 hours post-infestation (hpi). To achieve this, the expression of epidermal differentiation complex (EDC) genes and epidermal barrier proteins, the nature and severity of epidermal pathology and transepidermal water loss (TEWL) were evaluated.By 1 hpi a significant dermal polymorphonuclear infiltrate and a significant increase in TEWL with maximal mean TEWL (598.67 g/m2h) were observed. Epidermal pathology involving intra-epidermal pustulation, loss of epidermal architecture and damage to the basement membrane was seen by 3 hpi. Filaggrin and loricrin protein levels in the stratum corneum declined significantly in the first 24 hpi and qPCR validation confirmed the decrease in expression of the key EDC genesinvolucrin,filaggrinandloricrinobserved by microarray analysis, with 5.8-fold, 4.5-fold and 80-fold decreases, respectively by 24 hpi.The present study has demonstrated that earlyP. ovisinfestation disrupts the ovine epidermal barrier causing significant alterations in the expression of critical barrier components, epidermal pathology, and TEWL. Many of these features have also been documented in human and canine atopic dermatitis suggesting that sheep scab may provide a model for the elucidation of events occurring in the early phases of atopic sensitisation.
A survey of protein interaction data and multigenic inherited disorders
Authors: Mora Antonio , Michalickova Katerina , Donaldson Ian M 
Published: February 2013

Abstract

Background
Multigenic diseases are often associated with protein complexes or interactions involved in the same pathway. We wanted to estimate to what extent this is true given a consolidated protein interaction data set. The study stresses data integration and data representation issues.

Results
We constructed 497 multigenic disease groups from OMIM and tested for overlaps with interaction and pathway data. A total of 159 disease groups had significant overlaps with protein interaction data consolidated by iRefIndex. A further 68 disease overlaps were found only in the KEGG pathway database. No single database contained all significant overlaps thus stressing the importance of data integration. We also found that disease groups overlapped with all three interaction data types: n-ary, spoke-represented complexes and binary data - thus stressing the importance of considering each of these data types separately.

Conclusions
Almost half of our multigenic disease groups could potentially be explained by protein complexes and pathways. However, the fact that no database or data type was able to cover all disease groups suggests that no single database has systematically covered all disease groups for potential related complex and pathway data. This survey provides a basis for further curation efforts to confirm and search for overlaps between diseases and interaction data. The accompanying R script can be used to reproduce the work and track progress in this area as databases change. Disease group overlaps can be further explored using the iRefscape plugin for Cytoscape.
Newborn screening for citrin deficiency and carnitine uptake defect using second-tier molecular tests
Authors: Wang Li-Yun , Chen Nien-I , Chen Pin-Wen , Chiang Shu-Chuan , Hwu Wuh-Liang , Lee Ni-Chung , Chien Yin-Hsiu 
Published: February 2013

Abstract

Background
Tandem mass spectrometry (MS/MS) analysis is a powerful tool for newborn screening, and many rare inborn errors of metabolism are currently screened using MS/MS. However, the sensitivity of MS/MS screening for several inborn errors, including citrin deficiency (screened by citrulline level) and carnitine uptake defect (CUD, screened by free carnitine level), is not satisfactory. This study was conducted to determine whether a second-tier molecular test could improve the sensitivity of citrin deficiency and CUD detection without increasing the false-positive rate.

Methods
Three mutations in the SLC25A13 gene (for citrin deficiency) and one mutation in the SLC22A5 gene (for CUD) were analyzed in newborns who demonstrated an inconclusive primary screening result (with levels between the screening and diagnostic cutoffs).

Results
The results revealed that 314 of 46 699 newborns received a second-tier test for citrin deficiency, and two patients were identified; 206 of 30 237 newborns received a second-tier testing for CUD, and one patient was identified. No patients were identified using the diagnostic cutoffs. Although the incidences for citrin deficiency (1:23 350) and CUD (1:30 000) detected by screening are still lower than the incidences calculated from the mutation carrier rates, the second-tier molecular test increases the sensitivity of newborn screening for citrin deficiency and CUD without increasing the false-positive rate.

Conclusions
Utilizing a molecular second-tier test for citrin deficiency and carnitine transporter deficiency is feasible.
Methyl jasmonate abolishes the migration, invasion and angiogenesis of gastric cancer cells through down-regulation of matrix metalloproteinase 14
Authors: Zheng Liduan , Li Dan , Xiang Xuan , Tong Ling , Qi Meng , Pu Jiarui , Huang Kai , Tong Qiangsong 
Published: February 2013

Abstract

Background
Recent evidence indicates that methyl jasmonate (MJ), a plant stress hormone, exhibits anti-cancer activity on human cancer cells. The aim of this study is to determine whether sub-cytotoxic MJ can abolish the migration, invasion and angiogenesis gastric cancer cells.

Methods
Human gastric cancer cell lines SGC-7901 and MKN-45 were treated with diverse concentrations of MJ. Cell viability, proliferation, migration, invasion and angiogenesis capabilities of cancer cells were measured by MTT colorimetry, EdU incorporation, scratch assay, matrigel invasion assay, and tube formation assay. Gene expression was detected by western blot and real-time quantitative RT-PCR. Binding of transcription factor on gene promoter was detected by chromatin immunoprecipitation.

Results
Sub-cytotoxic (0.05 to 0.2 mM) MJ attenuated the migration, invasion and angiogenesis, but not the cell viability or proliferation, of gastric cancer cells in a time- and dose-dependent manner, with down-regulation of matrix metalloproteinase 14 (MMP-14) and its downstream gene vascular endothelial growth factor. Restoration of MMP-14 expression rescued the SGC-7901 and MKN-45 cells from sub-cytotoxic MJ-inhibited migration, invasion and angiogenesis. In addition, sub-cytotoxic MJ decreased the specificity protein 1 (Sp1) expression and binding on MMP-14 promoter, while restoration of Sp1 expression rescued the cancer cells from sub-cytotoxic MJ-mediated defects in MMP-14 expression, migration, invasion and angiogenesis.

Conclusions
Sub-cytotoxic MJ attenuates the MMP-14 expression via decreasing the Sp1 expression and binding on MMP-14 promoter, thus inhibiting the migration, invasion and angiogenesis of gastric cancer cells.
Lipoprotein metabolism in patients with type 1 diabetes under intensive insulin treatment
Authors: Feitosa Alina C R , Feitosa-Filho Gilson S , Freitas Fatima R , Wajchenberg Bernardo L , Maranhão Raul C 
Published: February 2013

Abstract

Background
Type 1 diabetes (T1DM) is frequently accompanied by dyslipidemia related with insulin-dependent steps of the intravascular lipoprotein metabolism. T1DM dyslipidemia may predispose to precocious cardiovascular disease and the lipid status in T1DM under intensive insulin treatment has not been sufficiently explored. The aim was to investigate the plasma lipids and the metabolism of LDL and HDL in insulin-treated T1DM patients with high glycemic levels.

Methods
Sixteen male patients with T1DM (26 ± 7 yrs) with glycated hemoglobin >7%, and 15 control subjects (28 ± 6 yrs) were injected with a lipid nanoemulsion (LDE) resembling LDL and labeled with 14C-cholesteryl ester and 3H-free-cholesterol for determination of fractional clearance rates (FCR, in h-1) and cholesterol esterification kinetics. Transfer of labeled lipids from LDE to HDL was assayed in vitro.

Results
LDL-cholesterol (83 ± 15 vs 100 ± 29 mg/dl, p=0.08) tended to be lower in T1DM than in controls; HDL-cholesterol and triglycerides were equal. LDE marker 14C-cholesteryl ester was removed faster from plasma in T1DM patients than in controls (FCR=0.059 ± 0.022 vs 0.039 ± 0.022h-1, p=0.019), which may account for their lower LDL-cholesterol levels. Cholesterol esterification kinetics and transfer of non-esterified and esterified cholesterol, phospholipids and triglycerides from LDE to HDL were also equal.

Conclusion
T1DM patients under intensive insulin treatment but with poor glycemic control had lower LDL-cholesterol with higher LDE plasma clearance, indicating that LDL plasma removal was even more efficient than in controls. Furthermore, HDL-cholesterol and triglycerides, cholesterol esterification and transfer of lipids to HDL, an important step in reverse cholesterol transport, were all normal. Coexistence of high glycemia levels with normal intravascular lipid metabolism may be related to differences in exogenous insulin bioavailabity and different insulin mechanisms of action on glucose and lipids. Those findings may have important implications for prevention of macrovascular disease by intensive insulin treatment.
Extinction and decay estimates of solutions for a porous medium equation with nonlocal source and strong absorption
Authors: Xu Xianghui , Fang Zhong Bo , Yi Su-Cheol 
Published: February 2013

Abstract
In this paper, we investigate extinction properties of the solutions for the initial Dirichlet boundary value problem of a porous medium equation with nonlocal source and strong absorption terms. We obtain some sufficient conditions for the extinction of nonnegative nontrivial weak solutions and the corresponding decay estimates which depend on the initial data, coefficients, and domains.
Randomized controlled trial comparing telephone and mail follow-up for recruitment of participants into a clinical trial of colorectal cancer screening
Authors: Wong Arthur D , Kirby John , Guyatt Gordon H , Moayyedi Paul , Vora Parag , You John J 
Published: February 2013

AbstractBackgroundInvestigators often face challenges when recruiting participants into randomized controlled trials (RCTs). Some data suggest that telephone reminders may lead to greater participant enrollment.MethodsPatients aged 50 to 70 years from family practice rosters were initially mailed invitations to participate in an RCT of colorectal cancer screening. Patients who did not respond were randomly allocated to follow-up invitations by either telephone or mail four weeks after the initial invitation. The primary outcome was attendance for eligibility screening with the study nurse.ResultsAfter mailing invitations to 1,348 patients, 104 patients were initially enrolled in the RCT of colon cancer screening. Of 952 patients who did not respond to the initial mailed invitation, we randomly allocated 480 to follow-up invitation by telephone and 472 to follow-up invitation by mail. Attendance for eligibility screening with the study nurse was more frequent when non-responders were followed-up by telephone (84/480, 17.5%) than by mail (43/472, 9.1%) (relative risk (RR) 1.92, 95% confidence interval (CI) 1.36 to 2.71,P< 0.001). Enrollment into the RCT was also greater among patients followed-up by telephone (59/480, 12.3%) compared to those followed-up by mail (35/472, 7.4%) (RR 1.66, 95% CI 1.11 to 2.47,P=0.01).ConclusionsTelephone-based follow-up results in greater enrollment compared to a mail-based method. Our findings should be of interest to investigators conducting RCTs, particularly trials of screening interventions involving asymptomatic participants for which volunteer participation may be challenging.Trial registrationClinicaltrials.gov NCT00865527
Relative bioavailability and comparative clinical efficacy of different ivermectin oral formulations in lambs
Authors: Suárez Gonzalo , Alvarez Luis , Castells Daniel , Correa Oscar , Fagiolino Pietro , Lanusse Carlos 
Published: February 2013

Abstract

Background
Several oral ivermectin (IVM) formulations for use in sheep are available in the pharmaceutical veterinary market in different countries. All of them are indicated at the same dose rate to treat the gastrointestinal nematodes. However, there is a lack of information on the relative systemic exposure (plasma bioavailability) and clinical efficacy among oral formulations routinely used in sheep. The main goal of the work reported here was to perform a pharmaco-parasitological assessment of three different IVM oral formulations in lambs infected with multiple resistant gastrointestinal nematodes. The comparative drug systemic exposure (IVM plasma concentrations) and nematodicidal efficacies (clinical efficacy) in lambs were determined for a reference (RF) and two different test (T1, T2) IVM oral formulations. One hundred and fifty six (n= 156) healthy Corriedale lambs, naturally infected with multiple resistant gastrointestinal nematodes were allocated into four experimental groups (n=39). Animals in each group received treatment (200 μg/kg) with either the RF, one of the test IVM formulations or were kept as untreated control. Blood samples were collected over 15 days post-treatment (n=8). The IVM plasma concentrations were measured by high performance liquid chromatography with fluorescence detection. The faecal nematode egg count reduction test (FECRT) (n=39) and evaluation of the clinical efficacy were performed at day 14 post-treatment (n=6), where a predominance of IVM highly resistant nematodes was observed.

Results and conclusions
Neither the overall kinetic behaviour nor the IVM systemic exposure differed among all the tested oral formulations. Equivalent efficacy results were obtained for the different preparations, with an evident therapeutic failure to control Haemonchus spp. and Teladorsagia circumcincta, which correlates with a high degree of nematode resistance to IVM.
Implementation of Universal Microsatellite Instability and Immunohistochemistry Screening for Diagnosing Lynch Syndrome in a Large Academic Medical Center
Authors: Heald Brandie , Plesec Thomas , Liu Xiuli , Pai Rish , Patil Deepa , Moline Jessica , Sharp Richard R. , Burke Carol A. , Kalady Matthew F. , Church James , Eng Charis 
Published: February 2013

Purpose In 2009, the Evaluation of Genomic Applications in Practice and Prevention recommended that all colorectal cancers (CRCs) be screened for Lynch syndrome (LS) through microsatellite instability (MSI) or immunohistochemistry (IHC). No studies report how this process is implemented on a health system–wide basis. Methods Since 2004, Cleveland Clinic has screened CRC specimens with MSI/IHC. Between January 2004 and July 2007, MSI/IHC results went only to the colorectal surgeon (approach 1). Between August 2007 and June 2008, colorectal surgeons and a genetic counselor received the MSI/IHC results, and the counselor e-mailed the colorectal surgeon regarding appropriate patients for genetic counseling (GC) referral (approach 2). After July 2008, the colorectal surgeon and counselor received MSI/IHC results, but the counselor contacted the patient to facilitate referral (approach 3). In approaches 2 and 3, patients were presumed to have sporadic CRC if the tumor lacked MLH1 expression and was also BRAF mutated or if the patient was diagnosed at age greater than 72 years and had no cancer family history. Results Abnormal MSI/IHC results occurred in 178 (16%) of 1,108 patients. In approach 1, 21 (55%) of 38 patients with abnormal MSI/IHC were referred for GC, 12 (32%) of 38 underwent GC, and 10 (26%) of 38 underwent genetic testing (GT). In approach 2, nine (82%) of 11 patients were referred for GC, seven (64%) of 11 underwent GC, and five (45%) of 11 underwent GT. In approach 3, 56 (100%) of 56 patients were referred for GC, 40 (71%) of 56 underwent GC, and 37 (66%) of 56 underwent GT. Time from referral to GC was 10-fold quicker in approach 3 than approach 1. Conclusion Implementation of universal MSI/IHC with GC/GT, along with effective multidisciplinary communication and plans of responsibility for patient contact, resulted in increased identification of patients with LS.
Legal Abortion Levels and Trends By Woman's Age at Termination
Authors: Sedgh Gilda , Bankole Akinrinola , Singh Susheela , Eilers Michelle 
Published: February 2013

AbstractContextAssessments of abortion levels and trends by women's age at termination can be used to monitor trends in unintended pregnancy by age and can inform relevant programs and policies.MethodsLegal abortion incidence data were compiled from national statistical offices and nationally representative surveys of more than 40 countries where legal abortion is generally available. Age‐specific abortion rates and percentage distributions of abortions by age were computed, and trends since 1996 and 2003 were examined. Subregional and regional estimates were developed for geographic areas where the majority of the population was represented by the data.ResultsThe median year for the most recent estimates of abortions by woman's age was 2009. Adolescents accounted for a smaller share of abortions than their share of the population in the majority of eligible countries with data. In most countries, the highest age‐specific abortion rates and proportions of abortions were among women aged 20–29. Since 1996, adolescent abortion rates have increased the most in Belgium, the Netherlands and Scotland (22–42%), and have decreased the most in Estonia, Hungary, Iceland, Slovakia and Slovenia (40–55%). The proportion of abortions obtained by adolescents was higher in North America (18%) than in Europe overall (11%), although the proportion in Northern Europe (18%) was the same as that in North America.ConclusionsHigher abortion rates in particular age‐groups probably reflect higher‐than‐average levels of unmet need for contraception or difficulty using methods consistently and effectively, and a stronger desire to avoid childbearing. Each of the patterns observed has implications for service and information needs within countries.
Transcranial endoscope-assisted skull base surgery – posterior fossa
Authors: Schroeder Henry W. S. 
Published: February 2013

Abstract
Endoscope-assisted microsurgery is a promising technique combining the advantages of the operating microscope with those of the endoscope. For lesions, which are visible in a straight line, the operating microscope, which provides a high resolution, excellent color fidelity, as well as stereoscopic vision, is the optimal visualization tool. For dissecting in deep and narrow surgical corridors and for working “around a corner”, high-definition endoscopes with various angles of view are used to reduce the amount of retraction and skull base drilling. The endoscope-assisted microsurgical technique enables a safe surgery in the posterior fossa even when lesions are not visible in a straight line. Although the endoscope-assisted microsurgical technique reduces definitely the invasiveness of the approach, it still remains open whether it improves the results compared to standard microsurgery.