bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autoimmune thyroid disease in Colombian patients with systemic lupus erythematosus
Authors: Franco Juan‐Sebastian , Amaya‐Amaya Jenny , Molano‐González Nicolás , Caro‐Moreno Julian , Rodríguez‐Jiménez Mónica , Acosta‐Ampudia Yeny , Mantilla Rubén D. , Rojas‐Villarraga Adriana , Anaya Juan‐Manuel 
Published: November 2014

SummaryObjectivesTo determine the prevalence and the predictive factors of autoimmune hypothyroidism (AH) within a systemic lupus erythematosus (SLE) cohort and to analyse the current information concerning the prevalence and impact of autoimmune thyroid disease (AITD) and thyroid autoimmunity in patients with SLE.MethodsA total of 376 patients with SLE were assessed for the presence of the following: (i) confirmed AH, (ii) positive thy‐roperoxidase/thyroglobulin antibodies [TPOAb/TgAb] without hypothyroidism, (iii) nonautoimmune hypothyroidism and (iv) SLE patients with neither. Multivariate analysis and a classification and regression tree model were used to analyse data. The current information was discussed through a systematic literature review (SLR).ResultsIn our cohort, the prevalence of confirmed AH was 12%. However, in euthyroid patients with SLE, TPOAb and TgAb were observed in 21% and 10%, respectively. Patients with confirmed AH were significantly older and had later age at onset of the disease. Smoking (adjusted odds ratio (AOR) 6·93, 95% CI 1·98–28·54, P = 0·004), Sjögren's Syndrome (SS) (AOR 23·2, 95% CI 1·89–359·53, P = 0·015) and positivity for anticyclic citrullinated peptide (anti‐CCP) (AOR 10·35, 95% CI 1·04–121·26, P = 0·047) were associated with AH‐SLE, regardless of gender and duration of the disease. Smoking and SS were confirmed as predictors of AH‐SLE. In the SLR, the prevalence of AITD ranged from 1% to 60%. The factors associated with this polyautoimmunity were female gender, older age, smoking, certain autoantibodies, SS, and cutaneous and articular involvement.ConclusionsAITD is frequent in SLE and does not affect the severity of SLE. Identified risk factors will assist clinicians in the search for AITD. Our results encourage smoke‐free policies in patients with SLE.
Low serum adiponectin levels are associated with reduced insulin sensitivity and lipid disturbances in short children born small for gestational age
Authors: Huang Yuefang , Li Yanhong , Chen Qiuli , Chen Hongshan , Ma Huamei , Su Zhe , Du Minlian 
Published: November 2014

SummaryBackgroundBeing born as small for gestational age (SGA) has an increased risk of developing metabolic/cardiovascular disturbances in later life. The role of adiponectin in the metabolic disturbance in SGA children remained undefined.ObjectiveThe aim of this study was to investigate the association between serum levels of adiponectin and insulin sensitivity as well as lipid profile in short children born SGA at prepubertal ages.Patients and methodsSerum levels of adiponectin, fasting glucose, insulin, IGF‐I, IGFBP‐1, total cholesterol (TC), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), triglycerides (TG), apolipoprotein A‐I (ApoA‐I) and Apo B were measured in 30 prepubertal short children born SGA. Insulin resistance (IR) and β‐cell function were assessed using the method of homeostatic model (HOMA). Data were compared to those of 30 short appropriate for gestational age (AGA) children matched for age, gender, height and body mass index, and correlation analysis was performed.ResultsShort SGA children had significantly higher levels of fasting insulin, HOMA‐IR and HOMA‐β but lower levels of adiponectin than short AGA controls. No significant differences in the level of IGFBP‐1 and IGF‐I were found between the two groups. Serum levels of TC, TG, Apo B and Apo B/ApoA‐I ratio were significantly higher in SGA, with 33% of hypercholesteraemia and 23% of hyperglyceridaemia. Stepwise multiple regression analysis revealed that serum adiponectin level was negatively correlated with HOMA‐IR and TG and was positively correlated with birthweight SDS in SGA children.ConclusionsThese findings suggest that low serum adiponectin levels are associated with reduced insulin sensitivity and unfavourable lipid profiles in short children born SGA at prepubertal ages.
Evaluation of novel resorbable membranes for bone augmentation in a rat model
Authors: Zeng Ni , van Leeuwen Anne , Yuan Huipin , Bos Ruud R. M. , Grijpma Dirk W. , Kuijer Roel 
Published: November 2014

AbstractObjectivesOur study compared two novel, biodegradable poly(trimethylene carbonate) (PTMC) barrier membranes to clinically applied barrier membranes in maintaining volume of block autologous bone grafts in a rat mandible model.Material and methodsTwo hundred and forty rats were included in this study. Block autologous bone grafts of 5 mm in diameter were harvested from the mandibular angles and transplanted onto the contralateral side. The bone grafts were either covered with a membrane or left uncovered. The applied membranes included pure PTMC membranes, biphasic calcium phosphate (BCP) incorporated PTMC composite membranes, expanded poly(tetrafluoroethylene) (e‐PTFE) membranes (Tex) and collagen membranes (Geistlich Bio‐Gide). After 2, 4 and 12 weeks, the rat mandibles were retrieved and analysed by histological evaluation and μCT quantification.ResultsThe histological evaluation revealed that in time the block autologous bone graft was well integrated to the recipient bone via gradually maturing newly formed bone and did not show signs of resorption, independent of membrane coverage or types of membrane. μCT quantification showed the volume of the bone graft and recipient bone together was maintained by new bone formation and recipient bone resorption.ConclusionsOur study showed that the use of PTMC membranes and PTMC‐BCP composite membranes resulted in similar bone remodelling to the collagen membranes and e‐PTFE membranes and that the use of barrier membranes did not interfere with bone remodelling of the bone grafts and recipient bones. However, the used barrier membranes seemed not to contribute in maintaining the volume of block autologous bone grafts.
A minimally invasive technique for lateral maxillary sinus floor elevation: a Bayesian network study
Authors: Merli Mauro , Moscatelli Marco , Mariotti Giorgia , Pagliaro Umberto , Bernardelli Francesco , Nieri Michele 
Published: November 2014

AbstractObjectivesTo describe a minimally invasive technique for lateral maxillary sinus elevation and to identify the relationship between the involved factors.Materials and MethodsThis is a retrospective study on patients treated with an original minimally invasive technique for lateral maxillary sinus elevation in a private dental clinic from 2008 to 2013. Failures, complications, and radiographic measurements were registered 9 months after surgery at the provisional prosthesis delivery. The relationship between demographic and clinical factors was investigated using Bayesian network analyses.ResultsOne hundred and twenty‐four patients (147 maxillary sinuses) were treated, and 242 implants were placed. Seven patients dropped out. A total of two implants in two patients failed. Perforation of the sinus membrane occurred in seven patients (6%). Five different complications in five patients were observed. Mean peri‐implant marginal bone level 9 months after surgery was 1.10 ± 0.74 mm. Mean vertical bone gain was 7.44 ± 1.95 mm. Perforation was more frequently observed in patients that did not undergo the sedation procedure. Complications (excluding perforation and including implant failure) were more frequent in cases where only bone substitutes were used.ConclusionsThis technique can be considered noninvasive, with a low early failure and early complication rate.
Gender effect on the scapular 3D posture and kinematic in healthy subjects
Authors: Schwartz C. , Croisier J. L. , Rigaux E. , Brüls O. , Denoël V. , Forthomme B. 
Published: November 2014

SummaryPopulations considered for shoulder analysis are often composed of various ratios of men and women. It is consequently hypothesized that gender has no significant effect on the joint kinematic. However, the literature reports, for the shoulder, differences in the range of motion between genders. The specific influence of gender on the scapulo‐thoracic kinematics has not been studied yet. The dominant shoulder of two populations of men and women composed of 11 subjects each were evaluated in three dimensions for three distinct motions: flexion in the sagittal plane, abduction in the frontal plane and gleno‐humeral internal/external rotation with the arm abducted at 90°. Posture, kinematics and range of motion were studied separately. For flexion and abduction and with regard to the scapular kinematic, external rotation was significantly larger for women than men. The differences were of at least 5° at 120° of humeral elevation. Upward rotations were identical. Women also showed larger average active humero‐thoracic range of motion. The mean differences were of 13°, 7°, 12° and 5° for abduction, flexion, internal rotation and external rotation, respectively. No difference was observed between the scapular resting positions of both populations. The observed differences concerning both the scapular and humeral patterns would indicate that the shoulder behaviour of men and women should not be expected to be similar.
Outcomes after combined liver–kidney transplant vs. kidney transplant followed by liver transplant
Authors: Chan Edie Y. , Bhattacharya Renuka , Eswaran Sheila , Hertl Martin , Shah Nikunj , Fayek Sameh , Cohen Eric B. , Hollinger Edward F. , Olaitan Oyedolamu , Jensik Stephen C. , Perkins James D. 
Published: November 2014

AbstractIntroductionThe decision for isolated kidney transplant (KT) vs. combined liver–kidney transplant (CLKT) in patients with end‐stage renal disease (ESRD) with compensated cirrhosis remains controversial. We sought to determine outcomes of patients requiring listing for a liver transplant (LT) following either a cadaveric or living donor KT and compare these outcomes to similar patients receiving a CLKT.MethodsOur dataset included the United Network for Organ Sharing (UNOS)/Standard Transplant and Analysis and Research (STAR) kidney files from 1987 to 2012 after being joined with the liver files from 2002 to 2012. Outcomes of patients who received a CLKT with an international normalized ratio (INR) ≤1 and total bilirubin ≤1 were compared to patients who received a primary KT and subsequently required listing for LT between zero and five yr or after five yr.ResultsFor the three groups, 244 patients had a CLKT, 216 were wait‐listed for LT between zero and five yr after KT (0–5 WL), and 320 were wait‐listed five yr after KT (+5 WL). From the time of KT, the 0–5 WL group had significantly worse survival than the CLKT group and the +5 WL group. The +5 WL had the best survival of all groups. For the 0–5 WL group, 45% underwent LT and 40% died while waiting compared to the +5 WL group with 53% having LT and 26% died while waiting. At the time of LT, the 0–5 WL group had a higher model for end‐stage liver disease (MELD) score, higher incidence of being in the ICU at the time of transplant, and higher incidence of requiring life support. From the time of LT, the CLKT trended toward better survival (p = 0.0549) than both the 0–5 WL and +5 WL groups, which had equivalent survival.ConclusionThe 0–5 WL group is a higher risk group with poorer survival due to a higher incidence of dying on the waitlist. Better identification of patients with a high risk for hepatic decompensation following KT and agreement for regional exception for LT in the event of decompensation may improve utilization of organs and better survival for those patients.
Impact of human albumin infusion on organ function in orthotopic liver transplantation – a retrospective matched‐pair analysis
Authors: Ertmer Christian , Kampmeier Tim‐Gerald , Volkert Thomas , Wolters Heiner , Rehberg Sebastian , Morelli Andrea , Schmidt Hartmut , Lange Matthias , Boschin Matthias , Van Aken Hugo , Hahnenkamp Klaus 
Published: November 2014

AbstractBackgroundThe purpose of this study was to retrospectively analyze the impact of human albumin (HA) substitution on organ function in patients undergoing orthotopic liver transplantation (OLT).MethodsWe retrospectively analyzed chart data of 15 hypoalbuminemic patients who received continuous infusion of HA (100 g/d) for seven d following OLT and matched them with 15 control patients for severity scores at admission. Primary endpoint was a difference in mean “sequential organ failure assessment” (SOFA) score during 14 d following OLT. Secondary endpoints included SOFA subscores, length of intensive care unit (ICU) stay, ICU mortality, one‐yr mortality, fluid balance, colloid osmotic pressure (COP), serum albumin, and total protein concentrations.ResultsSubstitution of HA was associated with a lower mean SOFA score as compared to control (11.0 ± 3.6 vs. 13.4 ± 3.7; p < 0.001). Patients treated with HA also exhibited lower cardiovascular SOFA subscore and higher COP, serum albumin, and total protein concentrations. There were no significant differences in fluid balance, length of ICU stay, ICU mortality, or one‐yr mortality.ConclusionsThe present data suggest that continuous infusion of HA may preserve cumulative organ function (as measured by SOFA score) with emphasis on cardiovascular function in patients following OLT.
Long‐term impact of human leukocyte antigen mismatches combined with expanded criteria donor on allograft outcomes in deceased donor kidney transplantation
Authors: Shin Sung , Kim Young Hoon , Choi Byung Hyun , Choi Ji Yoon , Jung Joo Hee , Cho Han Kyung , Han Duck Jong 
Published: November 2014

AbstractThe long‐term impact of human leukocyte antigen (HLA) mismatches combined with expanded criteria donors (ECD) on clinical outcomes has not been fully evaluated in recipients of deceased donor (DD) kidney transplantations. Of 595 DD renal transplant recipients in our center between 1991 and 2011, 210 recipients (36%) had 0–3 HLA mismatches/standard criteria donor (SCD), 353 (59%) had 4–6 HLA mismatches/SCD or 0–3 HLA mismatches/ECD, and 32 (5%) had 4–6 HLA mismatches/ECD. The mortality rate was significantly highest in the patients with 4–6 HLA mismatches/ECD (p = 0.040). The most common cause of death in this group was infection (50%). There were no significant differences in overall graft survival and death‐censored graft survival. The biopsy‐proven acute rejection rate was significantly higher in the 4–6 HLA mismatches/ECD group (p = 0.011). Cox‐regression multivariate analyses showed that 4–6 HLA mismatches plus ECD (adjusted hazard ratio [AHR], 3.2; 95% confidence interval [CI], 1.17–10.56) and diabetes (AHR, 4.3; 95% CI, 1.50–12.28) were significant predictors of recipient mortality. In conclusion, ≥4 HLA mismatches plus ECD were associated with significantly higher rates of biopsy‐proven acute rejection and mortality compared with other groups undergoing DD kidney transplantation.
Low gravity rotational culture and the integration of immunomodulatory stem cells reduce human islet allo‐reactivity
Authors: Qureshi Khalid M. , Lee Jou , Paget Michelle B. , Bailey Clifford J. , Curnow S. John , Murray Hilary E. , Downing Richard 
Published: November 2014

AbstractModification of human islets prior to transplantation may improve long‐term clinical outcome in terms of diabetes management, by supporting graft function and reducing the potential for allo‐rejection. Intragraft incorporation of stem cells secreting beta (β)‐cell trophic and immunomodulatory factors represents a credible approach, but requires suitable culture methods to facilitate islet alteration without compromising integrity. This study employed a three‐dimensional rotational cell culture system (RCCS) to achieve modification, preserve function, and ultimately influence immune cell responsiveness to human islets. Islets underwent intentional dispersal and rotational culture‐assisted aggregation with amniotic epithelial cells (AEC) exhibiting intrinsic immunomodulatory potential. Reassembled islet constructs were assessed for functional integrity, and their ability to induce an allo‐response in discrete T‐cell subsets determined using mixed islet:lymphocyte reaction assays. RCCS supported the formation of islet:AEC aggregates with improved insulin secretory capacity compared to unmodified islets. Further, the allo‐response of peripheral blood mononuclear cell (PBMC) and purified CD4+ and CD8+ T‐cell subsets to AEC‐bearing grafts was significantly (p < 0.05) attenuated. Rotational culture enables pre‐transplant islet modification involving their integration with immunomodulatory stem cells capable of subduing the allo‐reactivity of T cells relevant to islet rejection. The approach may play a role in achieving acute and long‐term graft survival in islet transplantation.
Ectopic folliculosebaceous units at the coronal sulcus
Authors: Fernandez‐Flores Angel 
Published: November 2014

AbstractTyson glands were described in the 17th century as modified sebaceous glands of the coronal sulcus of the penis. However, this description and other early texts supporting the existence of Tyson glands were not accompanied by illustrations. The existence of such glands has been passing through the literature without adequate graphical demonstration, which has contributed to controversial debates. Herein we present a case of a partial penectomy performed on a 65‐year‐old man with a squamous cell carcinoma of the penis. In this case we identified sebaceous glands as well as folliculosebaceous units in the coronal sulcus. We also comparatively examined 12 cases of partial penectomy to search for sebaceous glands or folliculosebaceous units in the coronal sulcus or the preputium. We found neither sebaceous glands nor folliculosebaceous units at the coronal sulcus or the mucosal aspect of the prepuce. We conclude that: (1) folliculosebaceous units are possible in the coronal sulcus, as the current case illustrates for the first time in literature and (2) the current case is an oddity, probably induced by the accompanying squamous cell carcinoma, and therefore it may represent an ectopic folliculosebaceous unit rather than an anatomic variation.
Cerebral oxygenation is associated with neurodevelopmental outcome of preterm children at age 2 to 3 years
Authors: Verhagen Elise A , Van Braeckel Koenraad N J A , van der Veere Christa N , Groen Henk , Dijk Peter H , Hulzebos Christian V , Bos Arend F 
Published: November 2014

AimThe aim of the study was to determine whether regional cerebral tissue oxygen saturation (rcSO2) and fractional tissue oxygen extraction (FTOE), using near‐infrared spectroscopy, are associated with neurodevelopmental outcome of preterm infants.MethodWe measured rcSO2 on days 1, 2, 3, 4, 5, 8, and 15 after birth in 83 preterm infants (<32wks gestational age), and calculated FTOE=(SpO2–rcSO2)/SpO2. Cognitive, motor, neurological, and behavioural outcomes were determined at 2 to 3 years using the Bayley Scales of Infant and Toddler Development, Third Edition (BSID‐III), an age‐specific neurological examination, and the Child Behavior Checklist (CBCL) respectively. Multiple linear regression analyses were used to determine whether rcSO2 and FTOE contributed to outcome.ResultsWe followed up 67 infants. The lower quartile (P25–50) and highest quartile (P75–100) of rcSO2 on day 1 were associated with poorer cognitive outcome (p=0.044 and p=0.008 respectively). A lower area under the curve (AUC; over 15d) of rcSO2 was associated with poorer cognitive outcome (p=0.014). The lower quartile (P25–50) AUC of rcSO2 was associated with poorer fine motor outcome (p=0.004). The amount of time rcSO2 <50% on day 1 was negatively associated with gross motor outcome (p=0.002). The highest quartile of FTOE on day 1 was associated with poorer total motor outcome (p=0.041).InterpretationCerebral oxygen saturation during the first 2 weeks after birth is associated with neurodevelopmental outcome of preterm infants at 2 to 3 years. High and low rcSO2 on day 1 were associated with poorer neurodevelopmental outcome.
Prevalence and complications of trauma to the primary dentition in a subpopulation of Spanish children in southern Europe
Authors: Mendoza‐Mendoza Asuncion , Iglesias‐Linares Alejandro , Yañez‐Vico Rosa Mª , Abalos‐Labruzzi Camilo 
Published: November 2014

AbstractBackgroundDuring the first years of life, when children begin to walk and socialize, they are particularly vulnerable to traumatic injuries to the primary teeth; indeed, after dental caries, such injuries are the second most frequent cause of pediatric dental consultation. Nonetheless, the reported prevalence of trauma to the primary teeth varies depending on the literature source, type of injury, the patient's age, and the most common associated complications.AimTo analyze new epidemiological data and complications associated with traumatic injuries to the primary teeth of Spanish children.Material and methodsA retrospective study was carried out in a subpopulation of 879 Spanish children in southern Europe aged between one and 7 years old, with primary and early mixed dentition. Clinical and radiological records were obtained from all pediatric patients who presented trauma to the primary teeth, with a follow‐up period of 3–5 years.ResultsA total of 21.72% of children examined had some kind of dental trauma and the most common age range for injuries to the primary teeth was 1–3 years old. The most common injuries in deciduous teeth were subluxation (47.29% of injuries affected the periodontal ligament), intrusion (23.15%), and avulsion (13.63%). On the other hand, comparatively more complications were recorded as a result of intrusion (32 of 47 intruded teeth).ConclusionsIn this Spanish subpopulation, a pediatric dental consultation as a result of traumatic dental injuries in primary dentition is most frequent in 1‐ and 2‐year‐olds, and subluxation is the commonest injury in the primary dentition. In turn, intrusion is associated with an increased frequency of complications in both the deciduous and the permanent teeth.
Resistance to leakage of various thicknesses of apical plugs of Bioaggregate using liquid filtration model
Authors: Memiş Özgül Betül , Bezgin Tuğba , Şahin Cem , Sarı Şaziye 
Published: November 2014

AbstractAimThe aim of this study was to compare the resistance to leakage of different thicknesses of Bioaggregate (BA) and 4‐mm‐thick white mineral trioxide aggregate (WMTA) in an apexification model using liquid filtration.Methods32 extracted mandibular premolar teeth were sectioned at the cemento‐enamel junction and 3–4 mm from the tooth apex to obtain 12‐mm‐long root segments. The apical and coronal thirds were prepared with size two through six Gates Glidden burs. The teeth were divided into four groups according to material and thickness, as follows: Group 1: 2‐mm BA; Group 2: 4‐mm BA; Group 3: 12‐mm (total length) BA; Group 4: 4‐mm WMTA (control). The empty parts of the roots in Groups 1, 2, and 4 were filled with gutta‐percha and root canal sealer, and leakage was measured using fluid filtration. The data were analyzed using the Kruskal–Wallis H‐test.ResultsNo statistical differences in microleakage were observed between Groups 1, 2, and 4 (P > 0.05). Group 3 (roots filled completely with BA) showed significantly less leakage than the other groups tested (P < 0.01).ConclusionsThe findings of this study showed that 12 mm of BA exhibited the best resistance to leakage. At the same time, 2–4 mm of BA showed similar results when compared to 4‐mm MTA. In light of these results, this study suggests that BA may be a good candidate for further clinical studies when used as an apical barrier for apexification.