bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of waste generated from fresh Nile tilapia Oreochromis niloticus in Accra, Ghana
Authors: Otwey Richard Yaw , Atter Amy , Galley Christopher , Nketia Stephen , Lee Youngsun , Koivula Hanna M. , Agyakwah Seth K. 
Published: June 2024

AbstractAquaculture is a key component of Ghana's food system strategies, promoting sustainable animal protein production. Aquaculture complements traditional marine capture fisheries to close the gap between demand and supply. However, about one third of fish produced globally have been reported to go to waste yearly. Among the various cultured fish, the Nile tilapia Oreochromis niloticus is a predominant species. This study aimed to estimate the extent of Nile tilapia wastage by consumers in Ghana. A web‐based cross‐sectional consumer survey was designed to assess the parts of the tilapia consumers generally classified as edible or inedible, taking into account the three primary tilapia preparation methods. The study utilised a semi‐structured online questionnaire, gathering responses from 246 participants. The parts of Nile tilapia investigated included the flesh, fins, offal, head, scales, bones, and gill flaps/opercula. The analysis of consumed and wasted parts of Nile tilapias by weight showed that, on average, the flesh made up the majority of the fish at 55.26%, followed by the head at 26.46%, offal at 8.51%, scales at 3.10%, fins at 2.93%, bones at 2.76%, and operculum at 0.98%, which was the smallest component. The study concluded that approximately 30%–45% of waste is generated from Nile tilapia in the Ghanaian supply chain. Tilapia was widely consumed by all groups, with an average liking score of 7.69 ± 1.95 on a 10‐point hedonic scale. A significant association was found between gender and consumption patterns with females showing a higher degree of liking. There was a strong association between the method of preparation and consumption patterns; the fried parts were classified as more edible compared to those that were boiled or grilled. To reduce waste in the aquaculture industry, tilapia and other fishes could be processed in a way that various edible and inedible parts are sold separately.
Characterization of agronomic performance and sterility in triploid and diploid cannabinoid hemp
Authors: Suchoff David H. , Inoa Shannon Henriquez , Stack George M. , Wares Alexander J. , Snyder Stephen I. , Murdock Maylin J. , Rose Jocelyn K. C. , Smart Lawrence B. , Caton Tara A. , Pearce Robert C. 
Published: June 2024

AbstractCannabinoid hemp is a dioecious crop where pistillate plants are selectively grown to maximize cannabinoid yields. Errant pollination can reduce pistillate flower yields, cannabinoid concentrations, and lead to unmarketable flowers due to the presence of undesirable seeds. We compared pollen sensitivity and agronomic performance of diploid (2n = 2x = 20 chromosomes) and triploid (2n = 3x = 30 chromosomes) cannabinoid hemp in open‐field conditions. The high‐CBD variety Lifter and high‐CBG variety White CBG were evaluated in both their diploid and triploid counterparts in fields with and without pollen. Trials were conducted during the 2021 and 2022 field seasons in Kentucky, New York, and North Carolina (n = 6 site years). Triploids produced taller and wider plants than diploids; however, this did not result in yield differences in the pollen‐free environment. In the presence of pollen, triploid Lifter and White CBG produced 87% and 77% fewer seeds than their diploid counterparts, respectively. Increased seed production in diploids also resulted in a significant reduction of seed‐free biomass and cannabinoid concentrations compared to triploids. In the absence of pollen, we did not find any appreciable differences in seed‐free biomass or cannabinoid concentrations between triploids and diploids. Though not completely pollen‐insensitive, triploidy is an effective means to reduce seed production and improve yields and quality in cannabinoid hemp in the presence of pollen.
Synthesis of Isoquinoline‐Containing 5,6‐Dicyano‐2,1,3‐Benzothiadiazoles: Unusual Heterocyclization into Dibenzo‐1,6‐Naphthyridine Framework
Authors: Gribanov Pavel S. , Vorobyeva Daria V. , Loginov Dmitry A. , Tokarev Sergey D. , Philippova Anna N. , Smol'yakov Alexander F. , Masoud Salekh M. , Solyev Pavel N. , Osipov Sergey N. 
Published: June 2024

AbstractAn efficient access to novel families of cyano‐containing polyheteroaromatic D−A molecules with extended π‐conjugation, including dibenzo[c,h][1,6]naphthyridine derivatives, has been elaborated. The synthetic strategy is based on the sequence of metal‐catalyzed annulation and cross‐coupling reactions starting from available 4‐ethynyl‐5,6‐difluoro‐7‐(p‐methoxyphenyl)‐2,1,3‐benzothiadiazole to get a new series of isoquinoline‐linked BTD‐based D−A compounds, which further undergo a selective cyanation to afford the corresponding mono‐CN‐ or di‐CN‐BTD derivatives depending on the reaction conditions. In course of the investigation of cyanation process, a new type of intramolecular heterocyclization included the transformation of the benzothiadiazole core into hardly accessible dibenzo[c,h][1,6]naphthyridine framework has been unexpectedly discovered. The protocols developed tolerate a wide range of donor blocks such as diphenylamine, carbazole, dibenzoazepine and dihydroacridine.
Recent Advances in the Reaction of MBH Carbonates: Scope and Mechanism
Authors: Shao Yifan , Zhang Lei , Meng Xiangtai 
Published: June 2024

AbstractIn recent years, Morita‐Baylis‐Hillman (MBH) carbonates have been extensively used in domino reactions for the synthesis of novel cyclic and acyclic compounds. This review highlights the progress made in the last decade in the synthesis of a series of compounds from an uncyclized reaction or annulation of MBH carbonates, which demonstrates that the excellent reactivity and high research value of MBH carbonates as representative substrates in organic synthesis. We hope the summary and understanding of the reactivity of MBH carbonates can inspire chemists to apply these substrates in the design of more efficient domino reactions, which will be beneficial for the organic synthesis and drug chemistry.
Intralesional cidofovir injections for the treatment of multifocal exophytic sinonasal papilloma
Authors: Chatelet Florian , Vinciguerra Alessandro , Marc Morgane , Herman Philippe , Verillaud Benjamin 
Published: June 2024

Key points
Intralesional cidofovir injections in combination with surgery is an effective treatment for recurrent multifocal sinonasal exophytic papilloma.
No malignant transformation has been observed in our experience.
Anosmia is a potential side effect that patients should be aware of.
Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup
Authors: Jack Clifford R. , Andrews J. Scott , Beach Thomas G. , Buracchio Teresa , Dunn Billy , Graf Ana , Hansson Oskar , Ho Carole , Jagust William , McDade Eric , Molinuevo Jose Luis , Okonkwo Ozioma C. , Pani Luca , Rafii Michael S. , Scheltens Philip , Siemers Eric , Snyder Heather M. , Sperling Reisa , Teunissen Charlotte E. , Carrillo Maria C. 
Published: June 2024

AbstractThe National Institute on Aging and the Alzheimer's Association convened three separate work groups in 2011 and single work groups in 2012 and 2018 to create recommendations for the diagnosis and characterization of Alzheimer's disease (AD). The present document updates the 2018 research framework in response to several recent developments. Defining diseases biologically, rather than based on syndromic presentation, has long been standard in many areas of medicine (e.g., oncology), and is becoming a unifying concept common to all neurodegenerative diseases, not just AD. The present document is consistent with this principle. Our intent is to present objective criteria for diagnosis and staging AD, incorporating recent advances in biomarkers, to serve as a bridge between research and clinical care. These criteria are not intended to provide step‐by‐step clinical practice guidelines for clinical workflow or specific treatment protocols, but rather serve as general principles to inform diagnosis and staging of AD that reflect current science.Highlights
We define Alzheimer's disease (AD) to be a biological process that begins with the appearance of AD neuropathologic change (ADNPC) while people are asymptomatic. Progression of the neuropathologic burden leads to the later appearance and progression of clinical symptoms.
Early‐changing Core 1 biomarkers (amyloid positron emission tomography [PET], approved cerebrospinal fluid biomarkers, and accurate plasma biomarkers [especially phosphorylated tau 217]) map onto either the amyloid beta or AD tauopathy pathway; however, these reflect the presence of ADNPC more generally (i.e., both neuritic plaques and tangles).
An abnormal Core 1 biomarker result is sufficient to establish a diagnosis of AD and to inform clinical decision making throughout the disease continuum.
Later‐changing Core 2 biomarkers (biofluid and tau PET) can provide prognostic information, and when abnormal, will increase confidence that AD is contributing to symptoms.
An integrated biological and clinical staging scheme is described that accommodates the fact that common copathologies, cognitive reserve, and resistance may modify relationships between clinical and biological AD stages.
Metabolic Syndrome and Risk of Amyotrophic Lateral Sclerosis: Insights from a Large‐Scale Prospective Study
Authors: Zhang Junwei , Cao Wen , Xie Jiali , Pang Chunyang , Gao Lingfei , Zhu Luyi , Li Yaojia , Yu Huan , Du Lihuai , Fan Dongsheng , Deng Binbin 
Published: June 2024

ObjectiveAlthough metabolic abnormalities are implicated in the etiology of neurodegenerative diseases, their role in the development of amyotrophic lateral sclerosis (ALS) remains a subject of controversy. We aimed to identify the association between metabolic syndrome (MetS) and the risk of ALS.MethodsThis study included 395,987 participants from the UK Biobank to investigate the relationship between MetS and ALS. Cox regression model was used to estimate hazard ratios (HR). Stratified analyses were performed based on gender, body mass index (BMI), smoking status, and education level. Mediation analysis was conducted to explore potential mechanisms.ResultsIn this study, a total of 539 cases of ALS were recorded after a median follow‐up of 13.7 years. Patients with MetS (defined harmonized) had a higher risk of developing ALS after adjusting for confounding factors (HR: 1.50, 95% CI: 1.19–1.89). Specifically, hypertension and high triglycerides were linked to a higher risk of ALS (HR: 1.53, 95% CI: 1.19–1.95; HR: 1.31, 95% CI: 1.06–1.61, respectively). Moreover, the quantity of metabolic abnormalities showed significant results. Stratified analysis revealed that these associations are particularly significant in individuals with a BMI <25. These findings remained stable after sensitivity analysis. Notably, mediation analysis identified potential metabolites and metabolomic mediators, including alkaline phosphatase, cystatin C, γ‐glutamyl transferase, saturated fatty acids to total fatty acids percentage, and omega‐6 fatty acids to omega‐3 fatty acids ratio.InterpretationMetS exhibits a robust association with an increased susceptibility to ALS, particularly in individuals with a lower BMI. Furthermore, metabolites and metabolomics, as potential mediators, provide invaluable insights into the intricate biological mechanisms. ANN NEUROL 2024;96:788–801
Enantioselective Arylation of Sulfenamides to Access Sulfilimines Enabled by Palladium Catalysis
Authors: Yuan Yin , Han Yidan , Zhang Zhi‐kun , Sun Shijin , Wu Ke , Yang Junfeng , Zhang Junliang 
Published: June 2024

AbstractSulfur‐containing functional groups have garnered considerable attention due to their common occurrence in ligands, pharmaceuticals, and insecticides. Nevertheless, enantioselective synthesis of sulfilimines, particularly diaryl sulfilimines remains a challenging and persistent goal. Herein we report a highly enantio‐ and chemoselective cross–coupling of sulfenamides with aryl diazonium salt to construct diverse S(IV) stereocenters by Pd catalysis. Bisphosphine ligands bearing sulfinamide groups play a crucial role in achieving high reactivity and selectivity. This approach provides a general, modular and divergent framework for quickly synthesizing chiral sulfilimines and sulfoximines that are otherwise challenging to access. In addition, the origins of the high chemoselectivity and enantioselectivity were extensively investigated using density functional theory calculations.
Detection of Tumor‐Associated Autoantibodies in the Sera of Pancreatic Cancer Patients Using Engineered MUC1 Glycopeptide Nanoparticle Probes
Authors: Corzana Francisco , Asín Alicia , Eguskiza Ander , De Tomi Elisa , Martín‐Carnicero Alfonso , Martínez‐Moral María P. , Mangini Vincenzo , Papi Francesco , Bretón Carmen , Oroz Paula , Lagartera Laura , Jiménez‐Moreno Ester , Avenoza Alberto , Busto Jesús H. , Nativi Cristina , Asensio Juan L. , Hurtado‐Guerrero Ramón , Peregrina Jesús M. , Malerba Giovanni , Martínez Alfredo , Fiammengo Roberto 
Published: June 2024

AbstractPancreatic cancer is one of the deadliest cancers worldwide, mainly due to late diagnosis. Therefore, there is an urgent need for novel diagnostic approaches to identify the disease as early as possible. We have developed a diagnostic assay for pancreatic cancer based on the detection of naturally occurring tumor associated autoantibodies against Mucin‐1 (MUC1) using engineered glycopeptides on nanoparticle probes. We used a structure‐guided approach to develop unnatural glycopeptides as model antigens for tumor‐associated MUC1. We designed a collection of 13 glycopeptides to bind either SM3 or 5E5, two monoclonal antibodies with distinct epitopes known to recognize tumor associated MUC1. Glycopeptide binding to SM3 or 5E5 was confirmed by surface plasmon resonance and rationalized by molecular dynamics simulations. These model antigens were conjugated to gold nanoparticles and used in a dot‐blot assay to detect autoantibodies in serum samples from pancreatic cancer patients and healthy volunteers. Nanoparticle probes with glycopeptides displaying the SM3 epitope did not have diagnostic potential. Instead, nanoparticle probes displaying glycopeptides with high affinity for 5E5 could discriminate between cancer patients and healthy controls. Remarkably, the best‐discriminating probes show significantly better true and false positive rates than the current clinical biomarkers CA19‐9 and carcinoembryonic antigen (CEA).
A Covalent Organic Nanoribbon: Preparation, Single‐Crystal Structure with Chinese Luban Lock Configuration, and Photocatalytic Behavior
Authors: Zhang Lei , Chen Zihao , Li Xiao‐Xin , Wang Xiang , Gu Qianfeng , Wang Xin , Lee Chun‐Sing , Lan Ya‐Qian , Zhang Qichun 
Published: June 2024

AbstractThe multiple mortise‐and‐tenon joint parts are the core factors to provide the structural stability and diversity of Chinese Luban locks; however, constructing such structures is very challenging. Herein, single crystals of a covalent organic nanoribbon (named CityU‐27) are prepared through the assembly of hexahydroxytriphenylene (HHTP), 4,4′‐vinylenedipyridine (BYE), and phenylboronic acid (BA) together through dative boron←nitrogen (B←N) bonds. The single‐crystal X‐ray diffraction analysis indicates that CityU‐27 has a covalent organic nanoribbon structure, where each nanoribbon forms multiple and tight π–π interactions with four neighboring others to generate a Luban lock‐like configuration. CityU‐27 has been demonstrated to be an efficient photocatalyst in a one‐pot tandem reaction of hydrogen evolution reaction (HER) and semi‐hydrogenation reaction of alkynes in series to produce olefins without any additional photosensitizers and co‐catalysts (metal‐free).
Vanillin based phthalonitrile and acetylene bifunctional resins
Authors: Sitter James D. , Richardson Tyler , Wallace Jean M. , Lusk Clair , Brown Loren C. , Laskoski Matthew 
Published: June 2024

AbstractThe renewable and biosynthetic molecule, vanillin, were used in the preparation of new phthalonitrile (PN) and ethynylbenzene (EB) bifunctional resins without pre‐modification of the vanillin structure. This PN resin was characterized by differential scanning calorimetry, thermogravimetric analysis, nuclear magnetic resonance spectroscopy, rheometry, and single crystal x‐ray diffraction. The monomers exhibited excellent rheometric viscosities below 250 Cp at processing temperatures and a good pot life. After complete curing, the PN polymers exhibited thermal stability above 500°C, a glass transition temperature (Tg) above the final postcure temperature of 380°C, and exceptional retention of structural integrity over a large temperature range. These results suggest that vanillin derived EBPN based resins are excellent candidates for use in a variety of applications where high temperature and mechanical stability is critical.
Synergetic effect of the crosslinker size and polysaccharide type on the acrylamide networks
Authors: Keten Selinay , Gönülkirmaz Ferda , Karacan Pinar , Ceylan Deniz , Abdurrahmanoğlu Suzan 
Published: June 2024

AbstractThe microstructures of hydrogels dominate their properties such as swelling, mechanical, etc., and therefore, their applications. Possessing a homogeneous network lead to uniform swelling and mechanical properties throughout the material. Considering the synergistic effect of crosslinker size and polysaccharide variation, acrylamide hydrogels were synthesized in a single step reaction using tetraethyleneglycol dimethylacrylate (TEGDMA) as a crosslinker in the absence and presence of polysaccharides such as dextran, starch, and sodium alginate. By using the thermal initiator polysaccharides have been used directly without any pre‐functionalization in the single step gelation reaction. All the hydrogel samples were characterized by means of swelling, and mechanical and structural properties. Hydrogels synthesized with TEGDMA as a crosslinker were compared with conventional acrylamide gels prepared using N,N′‐methylenebis(acrylamide) (MBA) and the results emphasized the superior mechanical strength and flexibility of the gels obtained with TEGDMA. Both relatively longer crosslinker and polysaccharide additions have assisted in the formation of a more homogeneous acrylamide network. Polysaccharides which possess plenty of hydroxyl groups have provided a great impact on the swelling properties of the gel samples. Besides the carboxyl groups of alginate backbones have also increased the swelling ratio of the hydrogels additionally. The synergetic effect of the crosslinker and polysaccharide additives on the homogeneity of the acrylamide network and its swelling properties could be suggested for future applications, especially in the area of biomaterials.
Potential impact of economic incentives to reduce primary air emissions related to residential biomass combustion: the case of Lombardy region, Italy
Authors: Ozgen Senem 
Published: June 2024

AbstractThe paper explores the potential of the main state economic incentive (Conto Termico) designed to promote the use of renewable energy sources for heating and cooling purposes in residential buildings, aiming to reduce primary air emissions from residential biomass combustion (RBC). For this purpose, an emission reduction scenario involving the technological transition of biomass residential heating appliances was implemented in the lowland small‐medium municipalities of the Lombardy region in Italy, where households are connected to the natural gas grid but RBC is often practiced for economic reasons, contributing to severe air pollution problems related especially to particulate matter (PM) emissions. This technological turnover scenario (i.e. all biomass appliances in the area replaced by state‐of‐the‐art pellet appliances) resulted in a significant reduction of particulate matter emissions, while having only a minimal impact on NOx emissions. The incentivized cost for technological turnover (€15/kgPM10 avoided) was in line with the social costs associated with health impacts related to PM10 in a rural setting such as the study area. Given the one‐off investment support provided by a recently adopted national decree (DM 15/09/2022), biomethane emerges as a promising renewable energy alternative to decrease PM and NOx emissions from RBC in Lombardy region, characterized by an extensive natural gas distribution network and potential waste feedstock for biomethane production. Despite the still elevated production costs, an analysis restricted to the incentivized segment reveals that supporting biomethane production through investment incentives is more cost‐effective (€8/kgPM10 avoided) than promoting technological turnover.
The capabilities of sports as an option for poverty reduction strategy: Citizen perspective
Authors: Luguterah Austin Wontepaga , Mohammed Salifu Maigari , Apaak Daniel , Abieraba Richard Samuel Kwadwo 
Published: June 2024

AbstractWhen implemented strategically, sports can address various socio‐economic challenges and contribute to improving the well‐being of individuals and communities. This study explores the perceptions of citizens on the capabilities of sports in its present state in Ghana as an option for poverty reduction strategy. The researchers combined both qualitative and quantitative approaches, methodologies and techniques in this study. The researchers made use of questionnaires and interviews to gather data for this study. The study implored the integration of data methods by using sequential approach, and the six steps of thematic analysis proposed by Braun and Clarke (2012, Thematic analysis, American Psychological Association) in the data analysis. The research recognised that participation in sports can improve one's health, give one life skills and foster a sense of community togetherness. However, given the weak foundation for sports development in Ghana, the current situation of sports in the country cannot be used as a strategy for reducing poverty.
The impact of mental toughness on resilience and well‐being: A comparison of hearing‐impaired and non‐hearing‐impaired athletes
Authors: Akoğlu Halil Erdem , Cengiz Caner , Hazar Zekihan , Erdeveciler Övünç , Balcı Velittin 
Published: June 2024

AbstractThe purpose of this study is to investigate the impact of mental toughness levels on the psychological resilience and mental well‐being levels of hearing impaired and non‐hearing impaired athletes and the extent of the difference between hearing impaired and non‐hearing impaired athletes. The study group of the research consisted of 121 hearing impaired and 127 non‐hearing‐impaired athletes who continue their active sports life in Turkey. Convenience sampling method for non‐hearing‐impaired athletes and snowball sampling method for hearing impaired athletes were used for data collection. Data was collected online with Google Forms. In the study, structural equation modelling was conducted with Smart PLS program. In Model A, the direct effect of mental toughness on mental well‐being and resilience was determined. Model B showed that mental toughness directly affected mental well‐being and resilience. Mental toughness has a direct effect on psychological resilience and mental well‐being of hearing‐impaired athletes and non‐hearing‐impaired athletes. In addition, the mental toughness, psychological resilience and mental well‐being levels of hearing‐impaired athletes are higher than those of non‐hearing‐impaired athletes.