bluuebunny/crossref_metadata_2025_split huggingface dataset:
Macrophage plasticity: signaling pathways, tissue repair, and regeneration
Authors: Yan Lingfeng , Wang Jue , Cai Xin , Liou Yih‐Cherng , Shen Han‐Ming , Hao Jianlei , Huang Canhua , Luo Gaoxing , He Weifeng 
Published: August 2024

AbstractMacrophages are versatile immune cells with remarkable plasticity, enabling them to adapt to diverse tissue microenvironments and perform various functions. Traditionally categorized into classically activated (M1) and alternatively activated (M2) phenotypes, recent advances have revealed a spectrum of macrophage activation states that extend beyond this dichotomy. The complex interplay of signaling pathways, transcriptional regulators, and epigenetic modifications orchestrates macrophage polarization, allowing them to respond to various stimuli dynamically. Here, we provide a comprehensive overview of the signaling cascades governing macrophage plasticity, focusing on the roles of Toll‐like receptors, signal transducer and activator of transcription proteins, nuclear receptors, and microRNAs. We also discuss the emerging concepts of macrophage metabolic reprogramming and trained immunity, contributing to their functional adaptability. Macrophage plasticity plays a pivotal role in tissue repair and regeneration, with macrophages coordinating inflammation, angiogenesis, and matrix remodeling to restore tissue homeostasis. By harnessing the potential of macrophage plasticity, novel therapeutic strategies targeting macrophage polarization could be developed for various diseases, including chronic wounds, fibrotic disorders, and inflammatory conditions. Ultimately, a deeper understanding of the molecular mechanisms underpinning macrophage plasticity will pave the way for innovative regenerative medicine and tissue engineering approaches.
Associations between intolerance of uncertainty, paranoia, anxiety, and depression: Evidence from an international multisite sample
Authors: Morriss Jayne , Gaudiano Brandon A. , So Suzanne H. , Kingston Jessica , Lincoln Tania , Morris Eric M. J. , Ellett Lyn 
Published: August 2024

AbstractIntolerance of uncertainty (IU; the tendency to find uncertainty aversive) and paranoia (e.g., excessive mistrust of others), are both associated with anxiety and depression symptoms. While previous research has primarily focused on IU and paranoia separately, there is recent evidence to suggest that IU and paranoia are linked and may interact to increase risk for anxiety, depression, and schizophrenia‐spectrum conditions. The aims of the current study were to assess: (1) the extent to which IU (total score and subscales), paranoia, anxiety, and depression are associated and (2) whether the interaction between IU and paranoia is associated with greater anxiety and depression symptoms. To examine these aims, we conducted a survey in an international multisite sample (n = 2510). Questionnaires included: IU (total score and subscales), paranoia (RGPTS persecution subscale), anxiety, and depression. The findings revealed that: (1) IU was positively associated with paranoia (r = 0.43), anxiety (r = 0.48), and depression (r = 0.49), and (2) People with high scores on IU and paranoia showed higher anxiety and depression symptoms. Importantly, these effects remained when controlling for negative beliefs about the self and others and demographic factors. Additionally, the inhibitory IU subscale (uncertainty paralysis) was related to paranoia, anxiety, and depression. However, the prospective IU subscale (desire for predictability) was only related to depression, but not paranoia and anxiety. Overall, these findings reliably demonstrate that IU and paranoia are linked, and that IU and paranoia interactions may synergistically work to affect current levels of anxiety and depression symptoms.
Solanum melongena L. Extract Promotes Intestinal Tight Junction Re‐Assembly via SIRT‐1‐Dependent Mechanisms
Authors: Sukmak Pichayapa , Kulworasreth Purisha , Treveeravoot Supisara , Arinno Apiwan , Anuwongworavet Supitcha , Wachiradejkul Wanapas , Kulworasreth Purit , Teansuk Natnicha , Thongnak Laongdao , Amonlerdpison Doungporn , Inchai Jakkapong , Jakrachai Chaiwet , Akrimajirachoote Nattaphong , Aonbangkhen Chanat , Muanprasat Chatchai , Poolsri Wanangkan , Vaddhanaphuti Chutima S. , Pongkorpsakol Pawin 
Published: August 2024

AbstractTight junction disruption can lead to pathogenesis of various diseases without therapeutic strategy to recover intestinal barrier integrity. The main objective of this study is to demonstrate the effect of Solanum melongena L. extract (SMLE) on intestinal tight junction recovery and its underlying mechanism. Intestinal barrier function is attenuated by Ca2+ depletion. SMLE treatment increased TER value across T84 cell monolayers. Permeability assay reveals that Ca2+ depletion promotes 4‐kDa FITC‐dextran permeability, but not 70‐kDa FITC‐dextran. SMLE suppresses the rate of 4‐kDa FITC‐dextran permeability, indicating that SMLE inhibits paracellular leak pathway permeability. SMLE‐mediated TER increase and leak pathway suppression are abolished by neither calcium/calmodulin‐dependent protein kinase kinase β (CaMKKβ) inhibitor nor AMP‐activated protein kinase (AMPK) inhibitor. Furthermore, mammalian target of rapamycin (mTOR) and extracellular signal‐regulated kinase (ERK) inhibitors have no effects on SMLE‐mediated TER increase and leak pathway suppression. Interestingly, SMLE is unable to enhance TER value and diminish leak pathway permeability in T84 cell monolayers pre‐treated with sirtuin‐1 (SIRT‐1) inhibitor. Immunofluorescence staining reveals that SMLE enhances re‐assembly of tight junction proteins, including occludin and ZO‐1 to intercellular space but this effect is abolished by SIRT‐1 inhibitor. These data suggest that SMLE promotes intestinal tight junction re‐assembly via SIRT‐1‐dependent manner.
A Polarizable Forcefields for Glyoxal Acetals as Electrolyte Components for Lithium‐Ion Batteries
Authors: Pierini Adriano , Piacentini Vanessa , Gómez‐Urbano Juan Luis , Balducci Andrea , Brutti Sergio , Bodo Enrico 
Published: August 2024

AbstractIn this work we have derived the parameters of an AMOEBA‐like polarizable forcefield for electrolytes based on tetramethoxy and tetraethoxy‐glyoxal acetals, and propylene carbonate. The resulting forcefield has been validated using both ab‐initio data and the experimental properties of the fluids. Using molecular dynamics simulations, we have investigated the structural features and the solvation properties of both the neat liquids and of the corresponding 1 M LiTFSI electrolytes at the molecular level. We present a detailed analysis of the Li ion solvation shells, of their structure and highlight the different behavior of the solvents in terms of their molecular structure and coordinating features.
Benchmarking the Match of Porous Carbon Substrate Pore Volume on Silicon Anode Materials for Lithium‐Ion Batteries
Authors: Xiao Yiming , Yi Si , Yan Zhilin , Qiu Xiaoyu , Ning Pengpeng , Yang Deren , Du Ning 
Published: August 2024

AbstractSilicon (Si) is one of the most promising anode materials for high‐energy‐density lithium‐ion batteries. However, the huge volume expansion hinders its commercial application. Embedding amorphous Si nanoparticles in a porous carbon framework is an effective way to alleviate Si volume expansion, with the pore volume of the carbon substrates playing a pivotal role. This work demonstrates the impact of pore volume on the electrochemical performance of the silicon/carbon porous composites from two perspectives: 1) pore volume affects the loadings of Si particles; 2) pore volume affects the structural stability and mechanical properties. The smaller pore volume of the carbon substrate cannot support the high Si loadings, which results in forming a thick Si shell on the surface, thereby being detrimental to cycling stability and the diffusion of electrons and ions. On top of that, the carbon substrate with a larger pore volume has poor structural stability due to its fragility, which is also not conducive to realizing long cycle life and high rate performance. Achieving excellent electrochemical performances should match the proper pore volume with Si content. This study will provide important insights into the rational design of the silicon/carbon porous composites based on the pore volume of the carbon substrates.
Quality TV Drama: Fields of Research and Practitioners’ Perspectives
Authors: Krauß Florian 
Published: August 2024

AbstractThis chapter goes into more detail about the term “quality TV drama” and the related field of research, dealing with the connection between television and quality. In addition to discussing the well-known quality TV criteria according to Robert J. Thompson (1996), to which a number of analyses link, this chapter identifies gaps in quality TV research as well as other contexts, which have mostly arisen through the single-minded attention on US series. German and public-service television fiction represent different contexts through which these gaps can be addressed. The chapter then explains that the aesthetic evaluations that discussions on quality TV and its storytelling and screenwriting inevitably lead to take place in specific contexts. This then opens up into an explanation of the book’s approach of considering quality TV drama as both a construction and an evaluation discourse by the television industry. Quality judgements, as becomes clear, shape different phases of television production, especially the screenwriting process, and consistently take place in project networks and screen idea work groups. The third and final part of this chapter explains what the analysed television professionals understood “quality TV” to mean and what textual aspects they attributed to it. With reference to well-known TV series, especially from the US and also Denmark, the practitioners particularly emphasised storylines across several episodes and the associated character development as (desirable) attributes of quality drama.
Quality Drama as Transnational Expansion: Exports and Local Specifics
Authors: Krauß Florian 
Published: August 2024

AbstractThis chapter analyses how practitioners are negotiating the transnational expansion of German television fiction and its industry in their discussions on quality TV. In doing so, this chapter takes into account local aspects and particularities that accompany processes of globalisation and transnationalisation in the sense of “glocalisation”. The chapter’s second part specifically deals with negotiations on series exports, which historically have taken place sporadically in the German context but for which, today, a larger number of licensees in different countries and territories are available, through transnational streaming services. English-speaking markets in particular are now showing greater openness to non-English (i.e. also German-language) series, although these remain niche programmes in the Anglo-American distribution context. The third and final part of Chapter 5 demonstrates how individual project networks and screen idea work groups and their practitioners are transnationalising in the context of export ambitions and the expanded television industry. The transnationality of individual screenwriters and other players, working groups and production companies, as becomes clear, can become a decisive criterion for evaluating, selecting and finally greenlighting television dramas, alongside the transnational potential of the content, narrative style and aesthetic at the textual level.
Analysis of Expansion Stress Evolution of Concrete Erosion Products for Ocean Engineering
Authors: Huang Haihan , Zhu Shengdong , You Xianhui , Song Qiming 
Published: August 2024

AbstractWith the deployment of China's “Maritime Power” strategy and the continuous development of ocean engineering, the safety and sustainability of concrete materials in ocean engineering need to be resolved urgently. In this paper, aiming at the concrete erosion caused by sulfate in marine environment, the evolution analysis of the expansion stress of the erosion products is carried out based on the principles of thermodynamics and crystallography. The results show that there is a liquid film between the ettringite and the pore wall during sulfate erosion in marine environment. The interfacial energy between reactants of different phases should not be neglected, and the liquid film thickness is negatively correlated with the expansion stress. The radial stress on concrete microstructure is composed of expansion stress, seawater pressure and interfacial energy between the concrete pore wall and the seawater. The trends of radial stresses in micro-voids and micro-cracks are basically similarly, both of which are negatively correlated with pore size and positively correlated with erosion time. In addition, the radial stresses in micro-cracks are generally greater than those in micro-voids. During the erosion process, the radial stress is positively correlated with the expansion extend of ettringite.
Numerical Study of the Long-Term Settlement of Deep Drainage Tunnels in Soft Stratum
Authors: Zhu Qixuan , Cao Zhijie , Xu Zhen , Sui Tao , Lü Xilin 
Published: August 2024

AbstractThe deep tunnel drainage system has been used to solve urban flooding issues recently. However, inadequate research was conducted on the long-term settlement of deep drainage tunnels in soft soils. In this paper, a quasi-static finite element simulation was conducted based on a pipeline model in submerged soft soils. The pipeline suffered from long-term water filling-discharge cycles, which led to the settlement of the underlying soils below the pipeline. Settlements induced by cumulative plastic strain and pore pressure dissipation are isolated. The results reveal that the dissipation-induced settlement is negligible, and a recently proposed cumulative deformation formulation can reasonably predict the settlement. During the whole cycle stages, soil settlements mainly occurred within a certain depth below the pipeline. These findings can provide useful references for designing and safely operating deep tunnel drainage systems in soft soil areas.
Fatigue Response Analysis of Wind Power Pile Foundation Under Full Cycle Action of Typhoon
Authors: Zhang Bo , Su Shiding , Wu Jiaqi , Lv Shuhui 
Published: August 2024

AbstractAs an important component of offshore wind turbine foundation, steel pipe piles are subject to cyclic loads in the marine environment for a long time, especially the waves caused by typhoon, which are easy to cause fatigue damage of steel pipe piles. Based on a project example, a load pile soil ternary fatigue analysis model is proposed by combining relevant specifications, structural mechanics and finite element method, and the important factors that affect the fatigue damage of pile foundation structures in the whole cycle of typhoon are pointed out. The method of fatigue response analysis of wind power pile foundation structure in this paper has certain guiding significance for practical engineering application.
Experimental Study on the Factors Influencing the Arch Height of Overlying Soil in Karst Area
Authors: Wu Di , Li Aiwen , You Yongli , Wu Jianjian 
Published: August 2024

AbstractOn the evolution of collapsed soil caves, it is important to consider the soil arching effect and the factors that influence arch height. This study examines the impact of collapse width and filling height on load distribution and soil displacement to uncover the stability mechanisms of soil cavities. The findings reveal that: (1) Explaining the formation of soil sinkholes in terms of load sharing, it is evident that the soil arching effect enables transfer of pressure exerted above the soil arch to the nearby stable region that results in stress deflection within the stable area. (2) Interpretation of soil cave evolution based on displacement angle, indicating that the process of collapsing the soil cave triggers the soil arch effect due to the uneven force of soil particles, leading to soil settlement. (3) Arch height is the primary factor for measuring the soil cave stability from the perspective of soil displacement. Compared to the factor of filling height, the collapse width has more influence on the arch height. Thus, engineers working in karst areas should prioritize understanding the stability mechanism of soil holes to enhance the safety and reliability of construction projects.
Experimental Study on Frost Heave Characteristics of Silty Clay Beneath Operating Stations in Twin Tunnel Freezing
Authors: Wang Lei 
Published: August 2024

AbstractArtificial ground freezing method construction is widely applied in the subway construction in Shanghai. In the project of the twin tunnel freezing method crossing the operating Line 10 station at No.18 Guoquan Road in Shanghai, the tunnel is located in the silty clay with a water content of 38.5%. The frost heave pressure of the silty clay will cause uplift and even cracking of the already operating station. Taking the Shanghai silty clay as the research object, this study investigates the influence of the cold end temperature and conductive temperature on the frost heave pressure of the soil through laboratory frost heave experiments and similar simulation experiments. The results show that under closed freezing conditions, there is a good linear relationship between the frost heave pressure of the silty clay and the cold end temperature, while under open freezing conditions, the frost heave pressure of the soil has a quadratic relationship with the temperature difference of the soil under the structure’s base plate. The research findings will provide valuable references for projects such as the freezing method for crossing operating stations and existing lines in Shanghai subway construction.
Study on the Engineering Characteristics of Deep Soft Soil in South China
Authors: Zhou Xudong , Chen Meijuan , Shi Peiyun 
Published: August 2024

AbstractBy testing the physical and mechanical properties of soft soil samples in Liuxi River Basin and analyzing them in comparison with the properties of soft soil in other areas of Guangdong, it is found that they are different from the properties of soft soil in other areas, which can provide a reference and guidance for the construction of soft soil foundation in Liuxi River Basin. It can provide reference and guidance for the construction on soft soil foundation in Liuxi River Basin.
Study on the Rationality of Tunnel Plane Strain Model Based on Stress Release Principle
Authors: Zhao Haijun , Liu Heyi , Chen Tiannan , Pei Jiangrong 
Published: August 2024

AbstractBased on the finite element difference software FLAC3D, a three-dimensional refined simulation model for tunnel excavation and a plane strain model based on the stress release principle were established. By comparing the deformation characteristics of surrounding rock and the stress distribution of support structures, it is concluded that, apart from slight differences in the stress distribution of the steel arch, the results of the plane strain model and the three-dimensional refined model show high consistency in the deformation characteristics of surrounding rock and the stress distribution of anchor bolts. The calculated results for the maximum load on a single anchor bolt differ by 13.25%, and the differences in surrounding rock deformation and the maximum load on the steel arch are both less than 8%. The plane strain model based on the stress release method can well match the three-dimensional refined model, indicating its feasibility for practical engineering analysis.
Hybrid inflation, reheating and dark radiation in a IIB perturbative moduli stabilization scenario
Authors: Ahmed Waqas , Karozas Athanasios , Leontaris George K. , Tavellaris Ilias 
Published: August 2024

Abstract
We study the cosmological implications of an effective field theory model derived within a configuration of D7 brane stacks in the framework of type-IIB string theory. We consider a suitable geometric setup where the Kähler moduli fields are stabilized and the parametric space is constrained so that a de Sitter vacuum is ensured. In addition to the moduli fields we also take into account the usual Higgs and matter fields included in the effective field theory. In this background, we implement the standard hybrid inflation scenario with a singlet scalar field acting as the inflaton and the Higgs states serving as waterfall fields. Radiative corrections and soft supersymmetry breaking terms play an essential role in the realization of a successful inflationary scenario consistent with the present cosmological data. Small tensor-to-scalar ratio values are predicted, which can be probed in future planned experiments. Further constraints on the model’s parameters are derived from bounds on dark radiation which is measured as a contribution to the effective number of neutrino species Neff. In particular, we find an excess of ∆Neff ≤ 0.95 at 2σ confidence level with natural values of the involved couplings.
The semi-classical saddles in three-dimensional gravity via holography and mini-superspace approach
Authors: Chen Heng-Yu , Hikida Yasuaki , Taki Yusuke , Uetoko Takahiro 
Published: August 2024

Abstract
We determine the complex geometries dual to the semi-classical saddles in three-dimensional gravity with positive or negative cosmological constant. We examine the semi-classical saddles in Liouville field theory and interpret them in terms of gravity theory. For this, we describe the gravity theory by Chern-Simons theory and classify the possible saddles based on the homotopy group argument. We further realize the semi-classical saddles using the mini-superspace model of quantum gravity and explicitly determine the integral contour. In the case of positive cosmological constant, we recovered the geometry used for no-boundary proposal of Hartle and Hawking. In the case of negative cosmological constant, the geometry can be identified with Euclidean anti-de Sitter space attached with imaginary radius spheres. The geometry should be unphysical and several arguments on this issue are provided. Partial results were already presented in our earlier letter, and more detailed derivations and explanations on the results are given along with additional results. In particular, we reproduce the classical Liouville action from the Chern-Simons formulation of dual gravity theory.
Non-relativistic limits of bosonic and heterotic Double Field Theory
Authors: Lescano Eric , Osten David 
Published: August 2024

Abstract
The known stringy non-relativistic (NR) limit of the universal NS-NS sector of supergravity has a finite Lagrangian due to non-trivial cancellations of divergent parts coming from the metric and the B-field. We demonstrate that in Double Field Theory (DFT) and generalised geometry these cancellations already happen at the level of the generalised metric, which is convergent in the limit c → ∞, implying that the NR limit can be imposed before solving the strong constraint. We present the c-expansion of the generalised metric, which reproduces the Non-Riemannian formulation of DFT at the (finite) leading order, and the c-expansion of the generalised frame, which contains divergences. We also extend this approach to the non-Abelian gauge field of Heterotic DFT assuming a convergent expansion for the O(D, D + n) generalised metric. From this proposal, we derive a novel c-expansion for the bosonic part of the heterotic supergravity which is, by construction, compatible with O(D, D)-symmetry.