bluuebunny/crossref_metadata_2025_split huggingface dataset:
REPUTASI PERUSAHAAN MANUFKATUR SEKTOR INDUSTRI BARANG KONSUMSI DI (BEI)
Authors: Hikmat Mira Nur , Anggriawan Muhammad Angga 
Published: August 2024

Nilai perusahaan dicerminkan oleh harga saham yang dipengaruhi oleh faktor internal dan eksternal. Faktor internal yang mempengaruhi nilai perusahaan diantaranya profitabilitas dan leverage. Tujuan dari penelitian ini adalah untuk mengetahui apakah profitabilitas dan leverage mamiliki pengaruh terhadap nilai perusahaan pada perusahaan manufaktur sektor industri barang konsumsi yang terdaftar di Bursa Efek Indonesia periode 2019-2021. Metode penelitian yang digunakan yaitu metode kuantitatif. Populasi dalam penelitian ini yaitu perusahaan sektor industri barang konsumsi yang terdaftar di BEI periode 2019-2021. Metode pengambilan sampel yang digunakan adalah metode purposive sampling sehingga didapat 26 perusahaan. Penelitian menggunakan jenis data sekunder dengan metode analisis regresi berganda pada program SPSS 25. Hasil pengujian variabel profitabilitas menunjukan nilai thitung sebesar 6,426 > dari ttabel 1,992 dengan nilai signifikansi 0,00 < 0,05. Pada variabel leverage nilai thitung 1,348 < dari ttabel 1,992 dengan taraf signifikansi 0,182>0,05. Hasil pengujian secara simultan menunjukan nilai fhitung 23,429> ftabel 3.12 dengan nilai signifikansi 0,00<0,05. Simpulan yang dapat diambil yaitu variabel profitabilitas berpengaruh terhadap nilai perusahaan sedangkan variabel leverage tidak berpengaruh terhadap nilai perusahaan. Hasil pengujian secara simultan menunjukan profitabilitas dan leverage berpengauh terhadap nilai perusahaan.
Keefektifan Pendekatan Joyfull Learning Berbasis Ice Breaking Untuk Meningkatkan Hasil Belajar Biologi Tentang Materi Substansi Genetik Pada SMA Kelas XII
Authors: Thahura Lu'lu' an , Lodang Hamka , Saleh Andi Rahmat 
Published: August 2024

Pembelajaran seringkali bersifat monoton karena hanya berpusat kepada guru tanpa melibatkan siswa sehingga tercipta pembelajaran yang membosankan. Untuk itu, diperlukan pendekatan yang sesuai untuk mencairkan suasana kaku dalam pembelajaran. Tujuan penelitian yaitu untuk mengetahui tingkat keefektifan pendekatan Joyfull Learning berbasis Ice Breaking untuk meningkatkan hasil belajar biologi tentang materi Substansi Genetik pada SMA kelas XII. Jenis penelitian ini adalah Pre-Eksperimental Design dengan desain One Group Preteset -Posttest. Populasi yaitu seluruh siswa kelas XII SMAN 14 Sinjai dengan jumlah 86 orang. Sampel dipilih secara purposive sampling yaitu kelas XII IPS 2 berjumlah 26 orang sebagai kelompok eksperimen. Intrumen penelitian berupa soal tes hasil belajar dan lembar observasi guru. Hasil penelitian menunjukkan 15 siswa berada pada kategori “Sedang”, 9 siswa pada kategori “Tinggi”, dan 2 siswa pada kategori “Sangat Tinggi”. Uji N-Gain menunjukkan nilai N-Gain sebesar 0,715 berada pada kategori tinggi dengan persentase sebesar 71,5%. Maka dari itu, dapat disimpulkan bahwa penerapan pendekatan Joyfull Learning berbasis Ice Breaking cukup efektif untuk meningkatkan hasil belajar biologi siswa kelas XII SMAN 14 Sinjai.
Representasi Nilai Budaya Suku Batak Pada Film Ngeri- Ngeri Sedap Karya Bene Dionysius Rajagukguk
Authors: Alam Muhammad Rafli Dwi Nur Alam , Anwari  
Published: August 2024

Film is a means of mass communication that is in demand by many people, besides that, film is able to provide information that is easily accepted by all walks of life. This study aims to determine the Representation of the Cultural Values of the Batak Tribe in the film Ngeri-Ngeri Sedap by Bene Dionysius Rajagukguk. As for this study, the researcher formulates the problem in this thesis into two, namely: (1) What are the iconic signs, indexes and redaction symbols in Bene Dionysius Rajagukguk's Ngeri-Ngeri Sedap film. (2) How is the representation of the cultural values of the Batak tribe in the film Ngeri-Ngeri Sedap by Bene Dionysius Rajagukguk. To answer the two formulations of the problem, the researcher conducted a study using Charles Sanders Pierce's Semiotics theory. This research is a non-stakeholder qualitative research. The form of analysis used is Charles Sanders Pierce's Semiotic theory using three types of signs, namely icons, indexes and symbols. The data for this study were collected through an analysis of each scene or scene in the Ngeri-Ngeri Sedap film. The results of this study indicate that the representation of the cultural values of the Batak people in the film Ngeri-Ngeri Sedap is shown through everyday scenes carried out by the characters Pak Domu, Mak Domu, Domu, Sarma, Gabe and Sahat. Symbols of cultural values of the Batak tribe are manifested through the use of language, clothing and customs. the meaning of the cultural symbol depicted in the film Ngeri-Ngeri Sedap is the culture of the Batak tribe which is very thick with its cultural values that have been passed down from generation to generation, so that it is able to become a guideline in carrying out social life.

Keyword: Representation, Cultural Values, Batak Tribe, Semiotic Analysis, Ngeri-Ngeri Sedap Films.
Mahar Uang Hiasan Menurut Perpektif Madzhab Imam Syafi’i dan Imam Hanafi
Authors: Janna Sirojul , Al-Amin Habibi 
Published: August 2024

This research is a qualitative field research. The author used three data collection techniques to obtain data, namely interviews, observation and documentation. The author uses data analysis techniques in the form of objective interpretations. The conclusion from the general research is that giving a dowry of decoration is permissible as long as it has economic value. Giving dowry in the form money, goods or services must have benefits for the life of his wife, including fulfilling the dowry requirements in Islamic law. The majority of married couples use dowry money as a symbol of marriage to make it look more impressive and unique. Imam Asy-syafi’I defines dowry as something that is obligatory because of marriage or intercourse, or the passing of a woman’s honor without power, such as the result of breastfeeding and the without al of witnesses. According to imam syafi’I the complete pillars of marriage are as follows: prospective wife, prospective husband, 2 witnesses, guardian, shighat. According to imam Hanafi, dowry is giving a number of assets which are the rights of the wife, because of marriage ties or because of different types of sexual relation based on Islamic law. The imam Hanafi school of are the right of the wife, due to a marriage contract, or due to actual intercourse. Meanwhile, according to imam malik, dowry is the cause and effect of the halal relationship between husband and wife. Imam hambali’s opinion is that dowry is a reward for a marriage, whether it is stated clearly in the marriage contract, determined after the contract is agreed upon by both parties, or determined by the judge.

Keyword: dowry money decoration
Konstruksi Makna Hijab Dalam Film Merindu Cahaya De Amstel Karya Arumi e.
Authors: Fadhilah Chusnul , Malayati Robi’ah Machtumah 
Published: August 2024

The association of hijab with the identity of Muslim women remains a subject of debate. Women have an important position in Islam. Islam is very concerned about the dignity and dignity of women. One of the social constructions formed by mass media is the social construction of veiled women. The social construction displayed by the mass media regarding veiled women fosters a certain image in society. Film is an audiovisual medium used to convey messages to groups of people congregating in a particular location. The main topic of discussion in this karya is the plot and specific details that are contained in the movie Merindu cahaya de Amstel. Qualitative research methods were used in this study. The purpose of this study is to describe the signs of the meaning of hijab and the structure of the meaning of hijab in the film Merindu Cahaya de Amstel by Arumi E. Maxstream Original and Unlimited Production. Utilized data collection techniques include document analysis and case study research. To answer the formulation of the problem described above, researchers use a qualitative approach using the semiotic analysis model of Charles Sanders Peirce. As a result, researchers found several meanings of hijab in the film Merindu Cahaya de Amstel: (1) The meaning of hijab as an identity Muslim women. (2) Maintain the social behavior of a Muslim woman. (3) Hijab embodying women with noble morals. (4) Exalting a person Muslimah. (5) Hijab as an obligation for Muslim women.
Keywords: Construction, Meaning of Hijab, Semiotics.
Unveiling microbial dynamics in lung adenocarcinoma and adjacent nontumor tissues: insights from nicotine exposure and diverse clinical stages via nanopore sequencing technology
Authors: Yang Kangli , Wang Shuaifeng , Ding Zheng , Zhang Kai , Zhu Weiwei , Wang Huifen , Pan Mengshu , Li Xiangnan , Wang Hongmin , Yu Zujiang 
Published: August 2024

BackgroundLung is the largest mucosal area of the human body and directly connected to the external environment, facing microbial exposure and environmental stimuli. Therefore, studying the internal microorganisms of the lung is crucial for a deeper understanding of the relationship between microorganisms and the occurrence and progression of lung cancer.MethodsTumor and adjacent nontumor tissues were collected from 38 lung adenocarcinoma patients and used nanopore sequencing technology to sequence the 16s full-length sequence of bacteria, and combining bioinformatics methods to identify and quantitatively analyze microorganisms in tissues, as well as to enrich the metabolic pathways of microorganisms.Resultsthe microbial composition in lung adenocarcinoma tissues is highly similar to that in adjacent tissues, but the alpha diversity is significantly lower than that in adjacent tissues. The difference analysis results show that the bacterial communities of Streptococcaceae, Lactobacillaceae, and Neisseriales were significantly enriched in cancer tissues. The results of metabolic pathway analysis indicate that pathways related to cellular communication, transcription, and protein synthesis were significantly enriched in cancer tissue. In addition, clinical staging analysis of nicotine exposure and lung cancer found that Haemophilus, paralinfluenzae, Streptococcus gordonii were significantly enriched in the nicotine exposure group, while the microbiota of Cardiobactereae and Cardiobacterales were significantly enriched in stage II tumors. The microbiota significantly enriched in IA-II stages were Neisseriaeae, Enterobacteriales, and Cardiobacterales, respectively.ConclusionNanopore sequencing technology was performed on the full length 16s sequence, which preliminarily depicted the microbial changes and enrichment of microbial metabolic pathways in tumor and adjacent nontumor tissues. The relationship between nicotine exposure, tumor progression, and microorganisms was explored, providing a theoretical basis for the treatment of lung cancer through microbial targets.
Development and eruption of human teeth in the Chinese population: a comprehensive dental atlas
Authors: Jayaraman Jayakumar 
Published: August 2024

AimThe first comprehensive chart on dental development was published 75 years ago based on Caucasian children and this has been used as a standard dental chart to date. Few population specific charts have been developed recently and updated dental charts on modern subjects can provide more information on dental development patterns. This study aims to construct a comprehensive dental atlas for modern Chinese children and young adults to assist in clinical, forensic, and public health applications.MethodsThe study sample comprised of 2,306 subjects, age ranging from 2 to 24 years belonging to Chinese ethnicity. Dental formation and eruption of permanent teeth and resorption of primary teeth were analyzed separately for females and males. For each age range, the number of teeth (n), and the stage of development was calculated for first (Q1), second (Q2) and third quartiles (Q3). Similar analysis was performed for the position of permanent teeth and the resorption of primary teeth. To determine the variations between the sex, Mann-Whitney U-test was conducted by comparing the median (Q2) stages.ResultsVariations in dental formation and eruption of permanent teeth and resorption of primary teeth were observed between maxillary and mandibular dentitions and between the sex, however the difference was not statistically significant (p = 0.535 to p = 1.000). The dental atlas was presented separately for Chinese females and males.ConclusionThis atlas on modern Chinese population serves as a practical tool to assist in clinical diagnosis and treatment planning, in forensic investigations as well as indicators of developments in public health.
Does autoimmune diseases increase the risk of frailty? A Mendelian randomization study
Authors: Zhou Jinlei , Zhang Yuan , Ni Ting , Li Yanlei , Shao Haiyu , Wang Fei , Xu Sen , Huang Yazeng , Zhang Jun , Zhao Tingxiao 
Published: August 2024

BackgroundThe causality of autoimmune diseases with frailty has not been firmly established. We conducted this Mendelian randomization (MR) study to unveil the causal associations between autoimmune diseases with frailty.MethodsA MR analyses were performed to explore the relationships between autoimmune disease and frailty, using summary genome-wide association statistics.ResultsThrough a comprehensive and meticulous screening process, we incorporated 46, 7, 12, 20, 5, and 53 single nucleotide polymorphisms (SNPs) as instrumental variables (IVs) for hypothyroidism, hyperthyroidism, rheumatoid arthritis (RA), type 1 diabetes (T1D), multiple sclerosis (MS), and overall autoimmune disease, respectively. Our analysis revealed that hypothyroidism (OR = 1.023, 95% CI: 1.008–1.038, p = 0.0015), hyperthyroidism (OR = 1.024, 95% CI: 1.004–1.045, p = 0.0163), RA (OR = 1.031, 95% CI: 1.011–1.052, p = 0.0017), T1D (OR = 1.011, 95% CI: 1.004–1.017, p = 0.0012), and overall autoimmune disease (OR = 1.044, 95% CI: 1.028–1.061, p = 5.32*10^-8) exhibited a positive causal effect on frailty. Conversely, there may be a negative causal association between MS (OR = 0.984, 95% CI: 0.977–0.992, p = 4.87*10^-5) and frailty. Cochran’s Q test indicated heterogeneity among IVs derived from hypothyroidism, hyperthyroidism, T1D, and overall autoimmune diseases. The MR-Egger regression analyzes revealed an absence of horizontal pleiotropy in any of the conducted analyses.ConclusionThis study elucidates that hypothyroidism, hyperthyroidism, RA, T1D, and overall autoimmune disease were linked to an elevated risk of frailty. Conversely, MS appears to be associated with a potential decrease in the risk of frailty.
Individuals carrying the HLA-B*15 allele exhibit favorable responses to COVID-19 vaccines but are more susceptible to Omicron BA.5.2 and XBB.1.16 infection
Authors: Meng Lingxin , Pan Yue , Liu Yueping , He Rui , Sun Yuting , Wang Chenhui , Fei Lei , Zhu Airu , Wang Zhongfang , An Yunfei , Wu Yuzhang , Diao Bo , Chen Yongwen 
Published: August 2024

BackgroundNatural infection or vaccination have provided robust immune defense against SARS-CoV-2 invasion, nevertheless, Omicron variants still successfully cause breakthrough infection, and the underlying mechanisms are poorly understood.MethodsSequential blood samples were continuously collected at different time points from 252 volunteers who were received the CanSino Ad5-nCoV (n= 183) vaccine or the Sinovac CoronaVac inactivated vaccine (n= 69). The anti-SARS-CoV-2 prototype and Omicron BA.5.2 as well as XBB.1.16 variant neutralizing antibodies (Nab) in sera were detected by ELISA. Sera were also used to measure pseudo and live virus neutralization assay. The associations between the anti-prototype Nab levels and different HLA-ABC alleles were analyzed using artificial intelligence (AI)-deep learning techniques. The frequency of B cells in PBMCs was investigated by flow cytometry assay (FACs).ResultsIndividuals carrying the HLA-B*15 allele manifested the highest concentrations of anti-SARS-CoV-2 prototype Nab after vax administration. Unfortunately, these volunteers are more susceptible to Omicron BA.5.2 breakthrough infection due to their sera have poorer anti-BA.5.2 Nab and lower levels of viral neutralization efficacy. FACs confirmed that a significant decrease in CD19+CD27+RBD+ memory B cells in these HLA-B*15 population compared to other cohorts. Importantly, generating lower concentrations of cross-reactive anti-XBB.1.16 Nab post-BA.5.2 infection caused HLA-B*15 individuals to be further infected by XBB.1.16 variant.ConclusionsIndividuals carrying the HLA-B*15 allele respond better to COVID-19 vax including the CanSino Ad5-nCoV and the Sinovac CoronaVac inactivated vaccines, but are more susceptible to Omicron variant infection, thus, a novel vaccine against this population is necessary for COVID-19 pandemic control in the future.
Identification of cross-talk pathways and PANoptosis-related genes in periodontitis and Alzheimer’s disease by bioinformatics analysis and machine learning
Authors: Chen Xiantao , Dai Yifei , Li Yushen , Xin Jiajun , Zou Jiatong , Wang Rui , Zhang Hao , Liu Zhihui 
Published: August 2024

Background and objectivesPeriodontitis (PD), a chronic inflammatory disease, is a serious threat to oral health and is one of the risk factors for Alzheimer’s disease (AD). A growing body of evidence suggests that the two diseases are closely related. However, current studies have not provided a comprehensive understanding of the common genes and common mechanisms between PD and AD. This study aimed to screen the crosstalk genes of PD and AD and the potential relationship between cross-talk and PANoptosis-related genes. The relationship between core genes and immune cells will be analyzed to provide new targets for clinical treatment.Materials and methodsThe PD and AD datasets were downloaded from the GEO database and differential expression analysis was performed to obtain DEGs. Overlapping DEGs had cross-talk genes linking PD and OP, and PANoptosis-related genes were obtained from a literature review. Pearson coefficients were used to compute cross-talk and PANoptosis-related gene correlations in the PD and AD datasets. Cross-talk genes were obtained from the intersection of PD and AD-related genes, protein-protein interaction(PPI) networks were constructed and cross-talk genes were identified using the STRING database. The intersection of cross-talk and PANoptosis-related genes was defined as cross-talk-PANoptosis genes. Core genes were screened using ROC analysis and XGBoost. PPI subnetwork, gene-biological process, and gene-pathway networks were constructed based on the core genes. In addition, immune infiltration on the PD and AD datasets was analyzed using the CIBERSORT algorithm.Results366 cross-talk genes were overlapping between PD DEGs and AD DEGs. The intersection of cross-talk genes with 109 PANoptosis-related genes was defined as cross-talk-PANoptosis genes. ROC and XGBoost showed that MLKL, DCN, IL1B, and IL18 were more accurate than the other cross-talk-PANoptosis genes in predicting the disease, as well as better in overall characterization. GO and KEGG analyses showed that the four core genes were involved in immunity and inflammation in the organism. Immune infiltration analysis showed that B cells naive, Plasma cells, and T cells gamma delta were significantly differentially expressed in patients with PD and AD compared with the normal group. Finally, 10 drugs associated with core genes were retrieved from the DGIDB database.ConclusionThis study reveals the joint mechanism between PD and AD associated with PANoptosis. Analyzing the four core genes and immune cells may provide new therapeutic directions for the pathogenesis of PD combined with AD.
Combining the deployment of only the distal basket segment of the EMBOTRAP III and an aspiration catheter for M2 occlusions: the ONE-SEG technique
Authors: Hamada Yuki , Matsuoka Hideki , Sato Shinsuke , Kawabata Yutaro , Iwamoto Kana , Ikeda Mei , Sato Takeo , Takaguchi Go , Takashima Hiroshi 
Published: August 2024

BackgroundEndovascular therapy (EVT) for distal medium vessel occlusions requires prioritizing effectiveness and safety. We developed a technique combining the deployment of only the distal basket segment of the EMBOTRAP III and an aspiration catheter (AC) for M2 occlusions, called the “ONE-SEG technique,” and evaluated its clinical and technical impacts.MethodsThis was a retrospective review of 30 consecutive patients with M2 segment middle cerebral artery occlusion treated using the ONE-SEG technique. This method involves deploying the EMBOTRAP III through a microcatheter in only one segment and guiding the AC to the M2 origin or distal M1. The rates of final-pass expanded thrombolysis in cerebral infarction (eTICI) scores of 2c/3 or 2b/2c/3, safety (symptomatic intracranial hemorrhage [sICH]), and clinical outcomes (modified Rankin Scale [mRS] score 0–2, 0–3 at 90 days, and mortality at 90 days) were evaluated.ResultsOf the 30 cases, 36.7% were female, and the mean age was 75.6 ± 11.0 years. The ONE-SEG technique was used for 17 cases (56.7%, median NIHSS 10 [5–15.5]) with primary M2 occlusion and 13 cases (43.3%, median NIHSS 20 [14–22.5]) with secondary M2 occlusion after proximal thrombus removal. The successful final reperfusion rate (eTICI 2b/2c/3) was 90% overall (27/30 cases). One case (3.3%) developed sICH with secondary M2 occlusion. At 3 months, mRS scores 0–2 were seen in 64.7% of patients with primary M2 occlusion (11/17 cases) and in 23.1% (3/13 cases) with secondary M2 occlusion.ConclusionEVT using the ONE-SEG technique appears to be safe and effective for M2 occlusion.
Sex differences in patterns of white matter neuroplasticity after balance training in young adults
Authors: Kirby Eric D. , Andrushko Justin W. , Boyd Lara A. , Koschutnig Karl , D’Arcy Ryan C. N. 
Published: August 2024

IntroductionIn past work we demonstrated different patterns of white matter (WM) plasticity in females versus males associated with learning a lab-based unilateral motor skill. However, this work was completed in neurologically intact older adults. The current manuscript sought to replicate and expand upon these WM findings in two ways: (1) we investigated biological sex differences in neurologically intact young adults, and (2) participants learned a dynamic full-body balance task.Methods24 participants (14 female, 10 male) participated in the balance training intervention, and 28 were matched controls (16 female, 12 male). Correlational tractography was used to analyze changes in WM from pre- to post-training.ResultsBoth females and males demonstrated skill acquisition, yet there were significant differences in measures of WM between females and males. These data support a growing body of evidence suggesting that females exhibit increased WM neuroplasticity changes relative to males despite comparable changes in motor behavior (e.g., balance).DiscussionThe biological sex differences reported here may represent an important factor to consider in both basic research (e.g., collapsing across females and males) as well as future clinical studies of neuroplasticity associated with motor function (e.g., tailored rehabilitation approaches).