bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optically Tunable Many‐Body Exciton‐Phonon Quantum Interference
Authors: Chang Si‐Jie , Huang Po‐Chun , Su Jia‐Sian , Hsieh Yu‐Wei , Quiroz Reyes Carlos Jose , Fan Ting‐Hsuan , Sun Han‐Sheng , Nguyem Ai‐Phuong , Liu Te‐I , Cheng Ho‐Wen , Lin Ching‐Wei , Hayashi Michitoshi , Yong Chaw‐Keong 
Published: August 2024

AbstractThis study introduces a novel paradigm for achieving widely tunable many‐body Fano quantum interference in low‐dimensional semiconducting nanostructures, beyond the conventional requirement of closely matched energy levels between discrete and continuum states observed in atomic Fano systems. Leveraging Floquet engineering, the remarkable tunability of Fano lineshapes is demonstrated, even when the original discrete and continuum states are separated by over 1 eV. Specifically, by controlling the quantum pathways of discrete phonon Raman scattering using femtosecond laser pulses, the Raman intermediate states across the excitonic Floquet band are tuned. This manipulation yields continuous transitions of Fano lineshapes from antiresonance to dispersive and to symmetric Lorentzian profiles, accompanied by significant variations in Fano parameter q and Raman intensity spanning 2 orders of magnitude. A subtle shift in the excitonic Floquet resonance is further shown, achieved by controlling the intensity of the femtosecond laser, which profoundly modifies quantum interference strength from destructive to constructive interference. The study reveals the crucial roles of Floquet engineering in coherent light‐matter interactions and opens up new avenues for coherent control of Fano quantum interference over a broad energy spectrum in low‐dimensional semiconducting nanostructures.
DrugFormer: Graph‐Enhanced Language Model to Predict Drug Sensitivity
Authors: Liu Xiaona , Wang Qing , Zhou Minghao , Wang Yanfei , Wang Xuefeng , Zhou Xiaobo , Song Qianqian 
Published: August 2024

AbstractDrug resistance poses a crucial challenge in healthcare, with response rates to chemotherapy and targeted therapy remaining low. Individual patient's resistance is exacerbated by the intricate heterogeneity of tumor cells, presenting significant obstacles to effective treatment. To address this challenge, DrugFormer, a novel graph‐augmented large language model designed to predict drug resistance at single‐cell level is proposed. DrugFormer integrates both serialized gene tokens and gene‐based knowledge graphs for the accurate predictions of drug response. After training on comprehensive single‐cell data with drug response information, DrugFormer model presents outperformance, with higher F1, precision, and recall in predicting drug response. Based on the scRNA‐seq data from refractory multiple myeloma (MM) and acute myeloid leukemia (AML) patients, DrugFormer demonstrates high efficacy in identifying resistant cells and uncovering underlying molecular mechanisms. Through pseudotime trajectory analysisunique drug‐resistant cellular states associated with poor patient outcomes are revealed. Furthermore, DrugFormer identifies potential therapeutic targets, such as COX8A, for overcoming drug resistance across different cancer types. In conclusion, DrugFormer represents a significant advancement in the field of drug resistance prediction, offering a powerful tool for unraveling the heterogeneity of cellular response to drugs and guiding personalized treatment strategies.
Revolutionizing Tetracycline Hydrochloride Remediation: 3D Motile Light‐Driven MOFs Based Micromotors in Harsh Saline Environments
Authors: Zhao Yu , Lin Jiawei , Wu Qing , Ying Yulong , Puigmartí‐Luis Josep , Pané Salvador , Wang Sheng 
Published: August 2024

AbstractTraditional light‐driven metal‐organic‐frameworks (MOFs)‐based micromotors (MOFtors) are typically constrained to two‐dimensional (2D) motion under ultraviolet or near‐infrared light and often demonstrate instability and susceptibility to ions in high‐saline environments. This limitation is particularly relevant to employing micromotors in water purification, as real wastewater is frequently coupled with high salinity. In response to these challenges, ultrastable MOFtors capable of three‐dimensional (3D) motion under a broad spectrum of light through thermophoresis and electrophoresis are successfully synthesized. The MOFtors integrated photocatalytic porphyrin MOFs (PCN‐224) with a photothermal component made of polypyrrole (PPy) by three distinct methodologies, resulting in micromotors with different motion behavior and catalytic performance. Impressively, the optimized MOFtors display exceptional maximum velocity of 1305 ± 327 µm s−1 under blue light and 2357 ± 453 µm s−1 under UV light. In harsh saline environments, these MOFtors are not only maintain high motility but also exhibit superior tetracycline hydrochloride (TCH) removal efficiency of 3578 ± 510 mg g−1, coupling with sulfate radical‐based advanced oxidation processes and peroxymonosulfate. This research underscores the significant potential of highly efficient MOFtors with robust photocatalytic activity in effectively removing TCH in challenging saline conditions, representing a substantial advancement in applying MOFtors within real‐world water treatment technologies.
WRN Nuclease‐Mediated EcDNA Clearance Enhances Antitumor Therapy in Conjunction with Trehalose Dimycolate/Mesoporous Silica Nanoparticles
Authors: Li Yinan , Huang Xiu , Li Yingying , Qiao Qingqing , Chen Caihong , Chen Yang , Zhong Weilong , Liu Huijuan , Sun Tao 
Published: August 2024

AbstractCurrent research on tumor fibrosis has focused on cancer‐associated fibroblasts, which may exert dual functions of tumor promotion and inhibition. Little attention has been paid to whether tumor cells themselves can undergo fibrotic transformation and whether they can inhibit parenchymal cells similar to pulmonary fibrosis, thus achieving the goal of inhibiting the malignant progression of tumors. To explore the significance of inducing tumor fibrosis for cancer treatment. This study utilizes mesoporous silica nanoparticles (MSN) loaded with Trehalose dimycolate (TDM) to induce tumor cell fibrosis through the dual effects of TDM‐induced inflammatory granuloma and MSN‐induced foreign body granuloma. The results show that TDM/MSN (TM) can effectively induce tumor fibrosis, manifested specifically by collagen internalization, and suppression of proliferation and invasion capabilities, suggesting the potential role of tumor fibrosis therapy. However, further investigation reveals that extrachromosomal DNA (ecDNA) mediates resistance to fibrosis induction. To comprehensively enhance the efficacy, WRN exonuclease is conjugated to TM to form new nanoparticles (TMW) capable of effectively eliminating ecDNA, globally promoting tumor cell fibroblast‐like transformation, and validated in a PDX model to inhibit cancer progression. Therefore, TMW, through inducing tumor cell fibrosis to inhibit its malignant progression, holds great potential as a clinical treatment strategy.
Tangled webs and spider‐flowers: Phylogenomics, biogeography, and seed morphology inform the evolutionary history of Cleomaceae
Authors: Saunders Theresa C. , Larridon Isabel , Baker William J. , Barrett Russell L. , Forest Félix , Françoso Elaine , Maurin Olivier , Rokni Saba , Roalson Eric H. 
Published: August 2024

AbstractPremiseCleomaceae is an important model clade for studies of evolutionary processes including genome evolution, floral form diversification, and photosynthetic pathway evolution. Diversification and divergence patterns in Cleomaceae remain tangled as research has been restricted by its worldwide distribution, limited genetic sampling and species coverage, and a lack of definitive fossil calibration points.MethodsWe used target sequence capture and the Angiosperms353 probe set to perform a phylogenetic study of Cleomaceae. We estimated divergence times and biogeographic analyses to explore the origin and diversification of the family. Seed morphology across extant taxa was documented with multifocal image‐stacking techniques and morphological characters were extracted, analyzed, and compared to fossil records.ResultsWe recovered a well‐supported and resolved phylogenetic tree of Cleomaceae generic relationships that includes 236 (~86%) species. We identified 11 principal clades and confidently placed Cleomella as sister to the rest of the family. Our analyses suggested that Cleomaceae and Brassicaceae diverged ~56 mya, and Cleomaceae began to diversify ~53 mya in the Palearctic and Africa. Multiple transatlantic disjunct distributions were identified. Seeds were imaged from 218 (~80%) species in the family and compared to all known fossil species.ConclusionsOur results represent the most comprehensive phylogenetic study of Cleomaceae to date. We identified transatlantic disjunctions and proposed explanations for these patterns, most likely either long‐distance dispersals or contractions in latitudinal distributions caused by climate change over geological timescales. We found that seed morphology varied considerably but mostly mirrored generic relationships.
Proton Intercalation into an Open‐Tunnel Bronze Phase with Near‐Zero Volume Change
Authors: Kawai Kosuke , Jang Seong‐Hoon , Igarashi Yuta , Yazawa Koji , Gotoh Kazuma , Kikkawa Jun , Yamada Atsuo , Tateyama Yoshitaka , Okubo Masashi 
Published: August 2024

AbstractManaging safety and supply‐chain risks associated with lithium‐ion batteries (LIBs) is an urgent task for sustainable development. Aqueous proton batteries are attractive alternatives to LIBs because using water and protons addresses these two risks. However, most host materials undergo large volume changes upon H+ intercalation, which induces intraparticle cracking to accelerates parasitic reactions. Herein, we report that Mo3Nb2O14 bronze exhibits reversible H+ intercalation (200 mAh g−1) with a Coulombic efficiency of 99.7 % owing to near‐zero volume change and solid‐solution‐type phase transition. Combination of experimental and theoretical analyses clarifies that rotation and shrinkage of open tunnels, which consist of flexible corner‐sharing Mo/NbOn polyhedra, relieve local structural distortions upon H+ intercalation to suppress intraparticle cracking. The prototype full cell of an aqueous proton battery with a Mo3Nb2O14 anode operates stably over 1000 charge/discharge cycles. This study reveals the importance of implementing distortion‐relieving voids in host materials to reduce volume change upon charge/discharge.
A Bandgap‐Tuned Tetragonal Perovskite as Zero‐Strain Anode for Potassium‐Ion Batteries
Authors: Yang Weijia , Huang Jun , Zheng Qinfeng , Chen Liwei , Orita Akihiro , Saito Nagahiro , Zhang Zhengxi , Zhang Yixiao , Yang Li 
Published: August 2024

AbstractPIBs are emerging as a promising energy storage system due to high abundance of potassium resources and theoretical energy density, however, progress of PIBs is severely hindered by structural instability and poor cycling of anode material during continual insertion and extraction of larger‐sized K+. Hence, developing anode material with structural stability and stable cycling remains a great challenge. Herein, band gap‐tuned Mo‐doped and carbon‐coated lead titanate (CMPTO) with zero‐strain K+ storage is presented as ultra‐stable PIBs anode. Mo doping introduces narrowed band gap and optimized crystal lattice for enhanced intrinsic electron and ion transfer. Demonstrated by in situ XRD characterizations, the crystal structure stays stable with unchanged peak positions, fully revealing zero‐strain characteristic of CMPTO anode during potassium storage for stable cyclic capability. Ultimately, CMPTO anode achieved ultra‐stable cycling performance of 7000 cycles at 500 mA g−1 with high capacity retention of 90 % and considerable specific capacity of 130.9 mAh g−1 after 600 cycles at 100 mA g−1; with relatively large density, CMPTO realized eminent volumetric capacity of 1111.09 mAh cm−3 and ultra‐long cycling life of 10000 cycles at 7041 mA cm−3. This work introduces a promisingly new route into developing anode materials with ultra‐stable performance for PIBs.
Regiodivergent Functionalization of Protected and Unprotected Carbohydrates using Photoactive 4‐Tetrafluoropyridinylthio Fragment as an Adaptive Activating Group
Authors: Cao Shen , Zhang Haobo , Chen Mingshuo , Zhu Niming , Zhan Beibei , Xu Peng , Chen Xiaoping , Yu Biao , Zhang Xiaheng 
Published: August 2024

AbstractThe selective functionalization of carbohydrates holds a central position in synthetic carbohydrate chemistry, driving the ongoing quest for ideal approaches to manipulate these compounds. In this study, we introduce a general strategy that enables the regiodivergent functionalization of saccharides. The use of electron‐deficient photoactive 4‐tetrafluoropyridinylthio (SPyf) fragment as an adaptable activating group, facilitated efficient functionalization across all saccharide sites. More importantly, this activating group can be directly installed at the C1, C5 and C6 positions of biomass‐derived carbohydrates in a single step and in a site‐selective manner, allowing for the efficient and precision‐oriented modification of unprotected saccharides and glycans.
Multifunctional nitrogen rich benzoxazines with imine moiety: Structural insights, hydrophobic and corrosion‐resistant applications
Authors: Krishnan Pavithran , Madesh Priyanka , Krishnasamy Balaji , Thamizselvi R. , Muthukaruppan Alagar 
Published: August 2024

AbstractHybrid hydroxynaphthaldehyde (HNA) based benzoxazine products with good thermal stability, anticorrosion and hydrophobic properties have been synthesized. Nitrogen rich Schiff base core bifunctional benzoxazines (HNAG‐f and HNBG‐f) and trifunctional benzoxazine (HNMA‐f) have been synthesized using amino‐derivatives and paraformaldehyde through Mannich condensation. The structural confirmation of benzoxazines was studied using ATR‐FTIR, HRMS and 1H‐NMR spectral analyses. The polymerization (curing) temperature and thermal stability were assessed by DSC and TGA respectively. Data from DSC and TGA studies infer that HNMA‐f possesses the lowest curing temperature of 213°C and the highest thermal stability with a char yield of 41% at 850°C respectively when compared to those of the polybenzoxazines synthesized. The values of LOI and HRI calculated using TGA data infer that all the polybenzoxazines can be used for self‐extinguishing, flame retardant and heat resistant applications. Corrosion results indicated that these benzoxazines exhibit the surface protection efficiency of 99% towards mild steel surfaces. The polybenzoxazines exhibited hydrophobic property with a water contact angle value (WCA) of above 140°. The value of WCA did not vary much on exposing the polybenzoxazine coating to chemical and UV treatments suggesting that the polybenzoxazine coatings are durable. Data from different studies infer that these benzoxazines can be used in the form of adhesives, coatings, and thermally stable, anticorrosive, and hydrophobic and UV resistant applications.
Cost‐effectiveness analysis of osimertinib plus chemotherapy for patients with EGFR‐mutated advanced non‐small cell lung cancer
Authors: Tian Wentao , Niu Lishui , Zhou Rongrong , Wang Ziqi , Ning Jiaoyang , Lu Ruoyu , Shi Yin , Tan Zhaohua 
Published: August 2024

AbstractIntroductionFirst‐line osimertinib plus chemotherapy significantly prolonged progression‐free survival of patients with EGFR‐mutated advanced non‐small cell lung cancer (NSCLC) compared to osimertinib, according to the FLAURA2 trial.MethodsWe established a Markov model to compare the cost‐effectiveness of osimertinib plus chemotherapy with that of osimertinib alone. Clinical data were obtained from the FLAURA and FLAURA2 trials, and additional data were extracted from online resources and publications. Sensitivity analyses were conducted to evaluate the robustness of the findings. We used A willingness‐to‐pay threshold of $150,000 per quality‐adjusted life‐years (QALYs) gained. The main outcomes were QALYs, overall costs, incremental cost‐effectiveness ratio (ICER), incremental net monetary benefit, and incremental net health benefit. Subgroup analyses were conducted according to patients' mutation type and central nervous system (CNS) metastatic status.ResultsIn a 20‐year time horizon, the ICER of osimertinib plus chemotherapy versus osimertinib alone was $223,727.1 per QALY gained. The sensitivity analyses identified the cost of osimertinib and the hazard ratio for overall survival as the top 2 influential factors and a 1.9% probability of osimertinib plus chemotherapy to be cost‐effective. The subgroup analyses revealed ICERs of $132,614.1, $224,449.8, $201,464.1, and $130,159.7 per QALY gained for L858R mutations, exon 19 deletions, CNS metastases, and no CNS metastases subgroups, respectively.ConclusionsFrom the perspective of the United States health care system, osimertinib plus chemotherapy is not cost‐effective compared to osimertinib alone for treatment‐naïve patients with EGFR‐mutated advanced NSCLC, but more favorable cost‐effectiveness occurs in patients with L858R mutations and patients without baseline CNS metastases.
Chidamide plus R‐GDP for relapsed/refractory diffuse large B‐cell lymphoma in patients ineligible for autologous transplantation: A prospective, single‐arm, phase II study
Authors: Chen Guang‐Liang , Xue Kai , Zhang Qunling , Xia Zu‐guang , Jin Jia , Li Ran , Liu Yizhen , Lv Fangfang , Hong Xiaonan , Li Xiaoqiu , Cao Junning 
Published: August 2024

AbstractBackgroundIn relapsed/refractory (R/R) diffuse large B‐cell lymphoma (DLBCL), a negative prognosis is frequently linked to heightened epigenetic heterogeneity. Chidamide, a selective histone deacetylase inhibitor, shows promise as a targeted therapy for R/R DLBCL by targeting abnormal epigenetic changes associated with poor prognosis.MethodsA cohort of 27 ineligible patients with R/R DLBCL participated in an open — label, single — arm study. Chidamide was administered orally at a dose of 30 mg twice weekly for one week during the induction monotherapy phase. The subsequent combination therapy phase involved oral chidamide at a dose of 20 mg twice weekly for two weeks, followed by a one‐week discontinuation period, in conjunction with intravenous R‐GDP every 21 days.ResultsAmong the cohort of 31 patients who underwent screening (median age: 67 years), 27 were ultimately included in the study, with 14 individuals successfully completing six cycles of C‐R‐GDP treatment. The overall best objective response rate was determined to be 79.1% (95% CI: 75.1%–83.3%), comprising a complete response rate of 45.8% (95% CI: 41.6%–49.9%) and a partial response rate of 33.3% (95% CI: 29.3%–37.4%). Within the subgroup of 14 patients who completed the full treatment regimen, the best objective response rate reached 100%, with 71.4% achieving complete response (n = 10) and 28.6% achieving partial response (n = 4). The median follow‐up period for these patients was 17.0 months, ranging from 3.5 to 55 months. Progression‐free survival was 5.9 months and overall survival was 48.3 months. Anemia was the most common adverse event, affecting all patients. Thrombocytopenia led to treatment interruption or dose reduction in 13 patients. Other common adverse events included hypocalcemia, hyponatremia, and hypokalemia. Three patients experienced grade 3 pneumonitis and one had grade 3 skin rash.ConclusionsChidamide combined with R‐GDP is a safe and effective treatment option for patients with R/R DLBCL who are not eligible for autologous stem cell transplantation.
Screening of gastric cancer diagnostic biomarkers in the homologous recombination signaling pathway and assessment of their clinical and radiomic correlations
Authors: Wu Ahao , Hu Tengcheng , Lai Chao , Zeng Qingwen , Luo Lianghua , Shu Xufeng , Huang Pan , Wang Zhonghao , Feng Zongfeng , Zhu Yanyan , Cao Yi , Li Zhengrong 
Published: August 2024

AbstractBackgroundHomologous recombination plays a vital role in the occurrence and drug resistance of gastric cancer. This study aimed to screen new gastric cancer diagnostic biomarkers in the homologous recombination pathway and then used radiomic features to construct a prediction model of biomarker expression to guide the selection of chemotherapy regimens.MethodsGastric cancer transcriptome data were downloaded from The Cancer Genome Atlas database. Machine learning methods were used to screen for diagnostic biomarkers of gastric cancer and validate them experimentally. Computed Tomography image data of gastric cancer patients and corresponding clinical data were downloaded from The Cancer Imaging Archive and our imaging centre, and then the Computed Tomography images were subjected to feature extraction, and biomarker expression prediction models were constructed to analyze the correlation between the biomarker radiomics scores and clinicopathological features.ResultsWe screened RAD51D and XRCC2 in the homologous recombination pathway as biomarkers for gastric cancer diagnosis by machine learning, and the expression of RAD51D and XRCC2 was significantly positively correlated with pathological T stage, N stage, and TNM stage. Homologous recombination pathway blockade inhibits gastric cancer cell proliferation, promotes apoptosis, and reduces the sensitivity of gastric cancer cells to chemotherapeutic drugs. Our predictive RAD51D and XRCC2 expression models were constructed using radiomics features, and all the models had high accuracy. In the external validation cohort, the predictive models still had decent accuracy. Moreover, the radiomics scores of RAD51D and XRCC2 were also significantly positively correlated with the pathologic T, N, and TNM stages.ConclusionsThe gastric cancer diagnostic biomarkers RAD51D and XRCC2 that we screened can, to a certain extent, reflect the expression status of genes through radiomic characteristics, which is of certain significance in guiding the selection of chemotherapy regimens for gastric cancer patients.
Association between changes in EEG alpha power and behavioural outcome in autistic children induced by child‐centred play therapy: A randomised controlled trial
Authors: Chan Kim‐Lui Raise , Ouyang Guang 
Published: August 2024

AbstractObjectiveThe traditional research on evaluating psychological interventions has primarily relied on behavioural measurements (e.g. self‐report questionnaires). This study aimed to investigate the effects of child‐centred play therapy (CCPT) on autistic children at both behavioural and neural levels, as well as the association between the changes in neural and behavioural measurements induced by CCPT. It is hypothesised that alpha power would increase after CCPT, along with improvements in social responsiveness, adaptive social behaviour and autism spectrum disorder (ASD) social symptom measures and that these changes would be correlated across participants.MethodA total of 65 autistic children were randomly assigned to a CCPT experimental group (n = 34; M age = 7.50) or a waitlist control group (n = 31; M age = 7.47). Electroencephalography (EEG) alpha power and behavioural data were recorded during pre‐ and post‐intervention assessment sessions. The behavioural measurements included the Social Responsiveness Scale‐2, Autism Spectrum Quotient—Child (social skill subscale) and Adaptive Behaviour Assessment System‐II (social domain). t‐Tests and correlational analyses were conducted to examine the CCPT effects and brain–behaviour associations.ResultsThe results confirmed the effects of CCPT at both neural and behavioural levels and the association between these two levels across participants. Specifically, individuals with larger increases in alpha power after CCPT also showed greater behavioural improvement.ConclusionThis study marks an initial endeavour, providing the first cross‐validation of CCPT effects on autistic children by demonstrating the brain–behaviour association. This approach advances the understanding of the therapeutic intervention effects of CCPT by presenting its multilevel impacts.