bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two mod-p Johnson filtrations
Authors: Cooper James 
Published: January 2015

We consider two mod-p central series of the free group given by Stallings and Zassenhaus. Applying these series to definitions of Dennis Johnson's filtration of the mapping class group, we obtain two mod-p Johnson filtrations. Further, we adapt the definition of the Johnson homomorphisms to obtain mod-p Johnson homomorphisms. We calculate the image of the first of these homomorphisms. We give generators for the kernels of these homomorphisms as well. We restrict the range of our mod-p Johnson homomorphisms using work of Morita. We finally prove the announced result of Perron that a rational homology 3-sphere may be given as a Heegaard splitting with gluing map coming from certain members of our mod-p Johnson filtrations.
Molecular Subtypes of Clear Cell Renal Cell Carcinoma Are Associated with Sunitinib Response in the Metastatic Setting
Authors: Beuselinck Benoit , Job Sylvie , Becht Etienne , Karadimou Alexandra , Verkarre Virginie , Couchy Gabrielle , Giraldo Nicolas , Rioux-Leclercq Nathalie , Molinié Vincent , Sibony Mathilde , Elaidi Reza , Teghom Corinne , Patard Jean-Jacques , Méjean Arnaud , Fridman Wolf Herman , Sautès-Fridman Catherine , de Reyniès Aurélien , Oudard Stéphane , Zucman-Rossi Jessica 
Published: January 2015

Abstract
Purpose: Selecting patients with metastatic clear-cell renal cell carcinoma (m-ccRCC) who might benefit from treatment with targeted tyrosine kinase inhibitors (TKI) is a challenge. Our aim was to identify molecular markers associated with outcome in patients with m-ccRCC treated with sunitinib.
Experimental Design: We performed global transcriptome analyses on 53 primary resected ccRCC tumors from patients who developed metastatic disease and were treated with first-line sunitinib. We also determined chromosome copy-number aberrations, methylation status, and gene mutations in von Hippel–Lindau and PBRM1. Molecular data were analyzed in relation with response rate (RR), progression-free survival (PFS), and overall survival (OS). Validation was performed in 47 additional ccRCC samples treated in first-line metastatic setting with sunitinib.
Results: Unsupervised transcriptome analysis identified 4 robust ccRCC subtypes (ccrcc1 to 4) related to previous molecular classifications that were associated with different responses to sunitinib treatment. ccrcc1/ccrcc4 tumors had a lower RR (P = 0.005) and a shorter PFS and OS than ccrcc2/ccrcc3 tumors (P = 0.001 and 0.0003, respectively). These subtypes were the only significant covariate in the multivariate Cox model for PFS and OS (P = 0.017 and 0.006, respectively). ccrcc1/ccrcc4 tumors were characterized by a stem-cell polycomb signature and CpG hypermethylation, whereas ccrcc3 tumors, sensitive to sunitinib, did not exhibit cellular response to hypoxia. Moreover, ccrcc4 tumors exhibited sarcomatoid differentiation with a strong inflammatory, Th1-oriented but suppressive immune microenvironment, with high expression of PDCD1 (PD-1) and its ligands.
Conclusions: ccRCC molecular subtypes are predictive of sunitinib response in metastatic patients, and could be used for personalized mRCC treatment with TKIs, demethylating or immunomodulatory drugs. Clin Cancer Res; 21(6); 1329–39. ©2015 AACR.
Mechanism and Ablation of Arrhythmia Following Total Cavopulmonary Connection
Authors: Correa Rafael , Sherwin Elizabeth D. , Kovach Joshua , Mah Douglas Y. , Alexander Mark E. , Cecchin Frank , Walsh Edward P. , Triedman John K. , Abrams Dominic J. 
Published: January 2015

Background—
The ability to identify and ablate different arrhythmia mechanisms after the total cavopulmonary connection has not been studied in detail.

Methods and Results—
After obtaining Institutional Review Board approval according to institutional guidelines, consecutive patients after a total cavopulmonary connection undergoing electrophysiology study over a 6-year period were included (2006–2012). Arrhythmia mechanism was determined, and the procedural outcome was defined as complete, partial success, or failure. A 12-point arrhythmia severity score was calculated for each patient at baseline and on follow-up. Fifty-seven procedures were performed on 52 patients (18.4±11.8 years; 53.0±27.2 kg). Access to the pulmonary venous atrium was necessary in 33 procedures, via fenestration (16) or transbaffle puncture (17), and in 2 cases, an additional retrograde approach was used. In total, 80 arrhythmias were identified in 47 cases: macroreentrant (n=25) or focal atrial tachycardia (n=8), atrioventricular nodal reentry tachycardia (n=13), reentry via an accessory pathway (n=4) or via twin atrioventricular nodes (n=4), ventricular tachycardia (n=5), and undefined atrial tachycardia (n=21). Procedural outcome in 32 patients who underwent ablation was complete success (n=25), partial success (n=3), failure (n=3), or empirical ablation (n=1). After successful ablation, there was a significant decrease in arrhythmia score over 18.2 (4–32) months follow-up, with a sustained trend even in the face of arrhythmia recurrence (50%).

Conclusions—
Arrhythmia mechanism post total cavopulmonary connection is highly varied, encompassing simple and more complex substrates, documentation of which facilitates a strategic approach to invasive arrhythmia management. Despite the anatomic limitations, successful and clinically meaningful ablation is possible.
Distal Embolization of Hydrophilic-Coating Material From Coronary Guidewires After Percutaneous Coronary Interventions
Authors: Grundeken Maik J. , Li Xiaofei , Kurpershoek C. Eline , Kramer Miranda C. , Vink Aryan , Piek Jan J. , Tijssen Jan G.P. , Koch Karel T. , Wykrzykowska Joanna J. , de Winter Robbert J. , van der Wal Allard C. 
Published: January 2015

Background—
Coronary guidewires are indispensable during percutaneous coronary interventions. Nowadays, most guidewires have hydrophilic coatings to improve their trackability, allowing easy lesion passage and facilitating balloon and stent positioning. Recent reports, however, have raised concerns about detachment and subsequent embolization of these hydrophilic coatings.

Methods and Results—
We have retrospectively reviewed the histological samples of the myocardium, obtained during autopsies in the period 2009 to 2013, from all patients who had a history of percutaneous coronary interventions (n=40). Foreign material was observed in the distal myocardium in 4 patients (10%). Furthermore, we have reviewed 205 thrombus specimens which were obtained during thrombus aspiration in the setting of primary percutaneous coronary interventions in the period 2005 to 2009. In 45% of the cases, foreign material was observed within the thrombus. Finally, we have examined the histopathologic appearance of hydrophilic-guidewire coating material ex vivo by embedding the coating in placenta specimen and cut and stain it in exactly the same manner as the myocardium and thrombus specimen. The histopathologic appearance of the hydrophilic coating ex vivo was identical to the foreign material found in vivo.

Conclusions—
Distal embolization of hydrophilic-coating material was observed in 10% of the patients who had a history of percutaneous coronary interventions. Hydrophilic-coating material was found in 45% of coronary thrombus specimen obtained during thrombus aspiration. These findings suggest that detachment and distal embolization of hydrophilic-coating material from coronary guidewires occur more often than the sparse literature on this topic suggests.
Duma i uprzedzenie. Znaczenie wyboru osoby transseksualnej na „przedstawiciela Narodu”
Authors: Jawor Anna 
Published: January 2015

Pride and prejudice. The significance of election of a transsexual person as a “representative of Nation”Ms. Anna Grodzka’s election to the Polish Parliament in 2011 was a crucial event because for the first time in Europe a transsexual person became a Member of Parliament, and thus was to represent all Poles at the national level. This event resulted in mixed reactions and comments: from euphoria to trauma, from great pride to deep prejudice. It is instrumental in self identification of Poles, nevertheless two different Polish “nations” make use of it, presenting two different languages and two absolutely separate pictures of Polish identity. The first approach is associated with such notions as freedom, equity, minority rights, multiculturalism. The other is connected with such phrases as original values, genuine Poles, God, and the regular family. Therefore contemporary war of cultures, that is a general conflict over values and collective identity, came to focus on the fact that Anna Grodzka became an MP. The author of the article, relying on Allan McKee’s interpretative analysis of cultural texts, in this case press articles, aims at an analysis of the role of Ms. Grodzka’s election for identity shaping processes among Poles. Duma i uprzedzenie. Znaczenie wyboru osoby transseksualnej na „przedstawiciela Narodu”Wybór Anny Grodzkiej na posłankę był przełomowym wydarzeniem, ponieważ po raz pierwszy w Europie osoba transseksualna została przedstawicielką wszystkich rodaków. Wydarzenie to wywołało jednak różne reakcje: od euforii do traumy, od wielkiej dumy do głębokich uprzedzeń. Służy ono bowiem samookreślaniu się Polaków, ale w taki sposób, że korzystają z niego w procesie samoidentyfikacji co najmniej dwa polskie „narody”, posługujące się językami uosabiającymi dwie zupełnie inne wizje polskości. Naród tych, którzy boją się o Polskę, utożsamianą z wiarą katolicką, tradycyjną rodziną i podziałem ról płciowych, dla których norma jest jedna, a wartości prawdziwe albo nieprawdziwe. I naród tych, którzy Polskę swą widzą barwną, różnorodną, wielokulturową, otwartą i zmienną. Fakt wyboru Anny Grodzkiej do Sejmu stał się więc jedną z soczewek, w której ogniskuje się współczesna wojna kultur, która jest w istocie symboliczną walką o to, kim jesteśmy jako Polacy i w jakim społeczeństwie chcemy żyć. Stosując, proponowaną przez Allana McKee, interpretatywną analizę tekstów kulturowych, w tym przypadku artykułów prasowych, staram się przybliżyć znaczenie tego wydarzenia dla procesów tożsamościowych Polaków.
Large Group Work: Identity Development and Its Significance for Achieving Race Equality
Authors: Woodger David 
Published: January 2015

This article examines and analyses the effectiveness of experiential large group work (between 24–35 students) in delivering community and youth work training at Goldsmiths1. It specifically focuses on students’ development and experience in their understanding of racism and identity. The training has refined a model of learning and teaching that combines large group work and experiential learning. It is in this arena that students explore and critically reflect on their life and work experiences. They learn to process and articulate their feelings and understandings across a wide range of issues that come from learning how to inwardly reflect and to develop an awareness of themselves and change. The article explores the experience of group work training and the significance of students’ development of their racial identity in effectively addressing racism. It draws on both the work of Paulo Freire (1972; 1995) on education and Pat de Maré (1975; 1991) on large groups. The article begins by examining some of the literature on both race and large groups followed by an exploration of racial identity and its development in the group work process in terms of distinct phases. It then discusses the importance of the large group and its relevance to development of racial identities. It concludes by highlighting the significance of the issue of racial identity in addressing racism.
Histological Analysis of the Structural Composition of Ankle Ligaments
Authors: Rein Susanne , Hagert Elisabet , Schneiders Wolfgang , Fieguth Armin , Zwipp Hans 
Published: January 2015

Background: Various ankle ligaments have different structural composition. The aim of this study was to analyze the morphological structure of ankle ligaments to further understand their function in ankle stability. Methods: One hundred forty ligaments from 10 fresh-frozen cadaver ankle joints were dissected: the calcaneofibular, anterior, and posterior talofibular ligaments; the inferior extensor retinaculum, the talocalcaneal oblique ligament, the canalis tarsi ligament; the deltoid ligament; and the anterior tibiofibular ligament. Hematoxylin-eosin and Elastica van Gieson stains were used for determination of tissue morphology. Results: Three different morphological compositions were identified: dense, mixed, and interlaced compositions. Densely packed ligaments, characterized by parallel bundles of collagen, were primarily seen in the lateral region, the canalis tarsi, and the anterior tibiofibular ligaments. Ligaments with mixed tight and loose parallel bundles of collagenous connective tissue were mainly found in the inferior extensor retinaculum and talocalcaneal oblique ligament. Densely packed and fiber-rich interlacing collagen was primarily seen in the areas of ligament insertion into bone of the deltoid ligament. Conclusions: Ligaments of the lateral region, the canalis tarsi, and the anterior tibiofibular ligaments have tightly packed, parallel collagen bundles and thus can resist high tensile forces. The mixed tight and loose, parallel oriented collagenous connective tissue of the inferior extensor retinaculum and the talocalcaneal oblique ligament support the dynamic positioning of the foot on the ground. The interlacing collagen bundles seen at the insertion of the deltoid ligament suggest that these insertion areas are susceptible to tension in a multitude of directions. Clinical Relevance: The morphology and mechanical properties of ankle ligaments may provide an understanding of their response to the loads to which they are subjected.
Validity of four screening scales for major depression in MS
Authors: Patten Scott B , Burton Jodie M , Fiest Kirsten M , Wiebe Samuel , Bulloch Andrew GM , Koch Marcus , Dobson Keith S , Metz Luanne M , Maxwell Colleen J , Jetté Nathalie 
Published: January 2015

Background: There is a role for brief assessment instruments in detection and management of major depression in MS. However, candidate scales have rarely been validated against a validated diagnostic interview. In this study, we evaluated the performance of several candidate scales: Patient Health Questionnaire (PHQ)-9, PHQ-2, Center for Epidemiologic Studies Depression rating scale (CES-D), and Hospital Anxiety and Depression Scale (HADS-D) in relation to the Structured Clinical Interview for DSM-IV (SCID). Methods: The sample was an unselected series of 152 patients attending a multiple sclerosis (MS) clinic. Participants completed the scales during a clinic visit or returned them by mail. The SCID was administered by telephone within two weeks. The diagnosis of major depressive episode, according to the SCID, was used as a reference standard. Receiver-operator curves (ROC) were fitted and indices of measurement accuracy were calculated. Results: All of the scales performed well, each having an area under the ROC > 90%. For example, the PHQ-9 had 95% sensitivity and 88.3% specificity when scored with a cut-point of 11. This cut-point achieved a 56% positive predictive value for major depression. Conclusions: While all of the scales performed well in terms of their sensitivity and specificity, the availability of the PHQ-9 in the public domain and its brevity may enhance the feasibility of its use.
What drives MRI-measured cortical atrophy in multiple sclerosis?
Authors: Popescu V , Klaver R , Voorn P , Galis-de Graaf Y , Knol DL , Twisk JWR , Versteeg A , Schenk GJ , Van der Valk P , Barkhof F , De Vries HE , Vrenken H , Geurts JJG 
Published: January 2015

Background: Cortical atrophy, assessed with magnetic resonance imaging (MRI), is an important outcome measure in multiple sclerosis (MS) studies. However, the underlying histopathology of cortical volume measures is unknown. Objective: We investigated the histopathological substrate of MRI-measured cortical volume in MS using combined post-mortem imaging and histopathology. Methods: MS brain donors underwent post-mortem whole-brain in-situ MRI imaging. After MRI, tissue blocks were systematically sampled from the superior and inferior frontal gyrus, anterior cingulate gyrus, inferior parietal lobule, and superior temporal gyrus. Histopathological markers included neuronal, axonal, synapse, astrocyte, dendrite, myelin, and oligodendrocyte densities. Matched cortical volumes from the aforementioned anatomical regions were measured on the MRI, and used as outcomes in a nested prediction model. Results: Forty-five tissue blocks were sampled from 11 MS brain donors. Mean age at death was 68±12 years, post-mortem interval 4±1 hours, and disease duration 35±15 years. MRI-measured regional cortical volumes varied depending on anatomical region. Neuronal density, neuronal size, and axonal density were significant predictors of GM volume. Conclusions: In patients with long-standing disease, neuronal and axonal pathology are the predominant pathological substrates of MRI-measured cortical volume in chronic MS.
Subclinical central inflammation is risk for RIS and CIS conversion to MS
Authors: Rossi S , Motta C , Studer V , Macchiarulo G , Germani G , Finardi A , Furlan R , Martino G , Centonze D 
Published: January 2015

Background: Subtle diffuse intrathecal inflammation is undetectable by conventional neuroimaging, and could influence multiple sclerosis (MS) disease course. Objective: To explore the role of subclinical persisting intrathecal inflammation in radiologically isolated syndrome (RIS) or clinically isolated syndrome (CIS) conversion to MS, and in early MS disease reactivation. Methods: One-hundred ninety-three subjects with RIS, CIS, relapsing–remitting (RR), or primary progressive (PP) MS were included, along with 76 matched controls. Cerebrospinal fluid (CSF) levels of interleukin-8 (IL-8), a major proinflammatory cytokine, were measured as a biomarker of intrathecal inflammation. Patients were followed up for 2 years. Clinical and imaging measures of disease progression were recorded. Results: High central contents of IL-8 were associated to clinical progression in subjects with RIS, and to the risk of conversion to MS in subjects with CIS. Asymptomatic intrathecal inflammation placed subjects at risk for MS conversion, even regardless lesion load. CSF IL-8 levels were higher in RR MS with high disease activity. Higher number of relapses in the first two years since diagnosis and shorter first inter-attack intervals were observed in patients with high levels of IL-8. Conclusion: IL-8 might provide utility in determining the presence of active intrathecal inflammation, and could be important in diagnostically undefined cases.
Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer
Authors: Le Dung T. , Wang-Gillam Andrea , Picozzi Vincent , Greten Tim F. , Crocenzi Todd , Springett Gregory , Morse Michael , Zeh Herbert , Cohen Deirdre , Fine Robert L. , Onners Beth , Uram Jennifer N. , Laheru Daniel A. , Lutz Eric R. , Solt Sara , Murphy Aimee Luck , Skoble Justin , Lemmens Ed , Grous John , Dubensky Thomas , Brockstedt Dirk G. , Jaffee Elizabeth M. 
Published: January 2015

Purpose GVAX pancreas, granulocyte-macrophage colony-stimulating factor–secreting allogeneic pancreatic tumor cells, induces T-cell immunity to cancer antigens, including mesothelin. GVAX is administered with low-dose cyclophosphamide (Cy) to inhibit regulatory T cells. CRS-207, live-attenuated Listeria monocytogenes–expressing mesothelin, induces innate and adaptive immunity. On the basis of preclinical synergy, we tested prime/boost vaccination with GVAX and CRS-207 in pancreatic adenocarcinoma. Patients and Methods Previously treated patients with metastatic pancreatic adenocarcinoma were randomly assigned at a ratio of 2:1 to two doses of Cy/GVAX followed by four doses of CRS-207 (arm A) or six doses of Cy/GVAX (arm B) every 3 weeks. Stable patients were offered additional courses. The primary end point was overall survival (OS) between arms. Secondary end points were safety and clinical response. Results A total of 90 patients were treated (arm A, n = 61; arm B, n = 29); 97% had received prior chemotherapy; 51% had received ≥ two regimens for metastatic disease. Mean number of doses (± standard deviation) administered in arms A and B were 5.5 ± 4.5 and 3.7 ± 2.2, respectively. The most frequent grade 3 to 4 related toxicities were transient fevers, lymphopenia, elevated liver enzymes, and fatigue. OS was 6.1 months in arm A versus 3.9 months in arm B (hazard ratio [HR], 0.59; P = .02). In a prespecified per-protocol analysis of patients who received at least three doses (two doses of Cy/GVAX plus one of CRS-207 or three of Cy/GVAX), OS was 9.7 versus 4.6 months (arm A v B; HR, 0.53; P = .02). Enhanced mesothelin-specific CD8 T-cell responses were associated with longer OS, regardless of treatment arm. Conclusion Heterologous prime/boost with Cy/GVAX and CRS-207 extended survival for patients with pancreatic cancer, with minimal toxicity.
Incorporating Root Crops under Agro-Forestry as the Newly Potential Source of Food, Feed and Renewable Energy
Authors: Widodo Yudi , Rahayuningsih St. A. , Saleh Nasir , Wahyuningsih Sri 
Published: January 2015

Entering the third millennium food and energy crisis is becoming more serious in line with water scarcity amid of climate change induced by global warming, that so called as FEWS (food energy and water scarcity). In the last five decades Indonesian agricultural development of food crops had been emphasized on cereals and grains based. Conversion of forest into agricultural field in the form of upland and lowland facilitated by irrigation is prioritized for cereals such as rice, maize as well as grain legumes such as soybean, peanut etc. Unfortunately, root crops which their main yield underground are neglected. At the end of second millennium Indonesia was seriously suffered from multi-crisis economic trap, so Indonesia as part of countries under World Food Program to import the huge of food to cover domestic consumption such as rice, wheat, soybean, corn etc. On the other hand, consumption of energy was also increase significantly. These conditions triggering government to stimulate integrated agricultural enterprises for providing abundance of food as well as adequate renewable energy. Although root crops were neglected previously, however from its biological potential to produce biomass promotes root crops into an appropriate position. The variability of root crops which ecologically can be grown from upland in dry areas till swampy submergence condition. Forest conversion into agricultural land is not allowed due to forest is useful to prevent global warming. Therefore, food, feed and fuel (renewable energy) production have to be able grown under agro-forestry. Fortunately the potential of root crops has competency to meet the current need to fulfil food, feed and fuel as well as fibre under future greener environment.