bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombectomy in Patients Ineligible for iv tPA (THRILL)
Authors: Bendszus Martin , Thomalla Götz , Knauth Michael , Hacke Werner , Bonekamp Susanne , Fiehler Jens 
Published: June 2015

Rationale A relevant proportion of patients with acute ischemic stroke are ineligible for intravenous thrombolysis with recombinant tissue plasminogen activator. Mechanical thrombectomy offers a treatment alternative for these patients; however, only few data are available on its safety and efficacy. Aims and/or hypothesis The aim of this study was to compare safety and efficacy of stent retrievers as device class with best medical care alone in acute stroke patients with large intracranial vessel occlusion in the anterior circulation who are not eligible for intravenous thrombolysis with recombinant tissue plasminogen activator up to eight-hours of symptom onset. Design ‘Thrombectomy in patients ineligible for iv tPA’ is a prospective, open-label, blinded end-point, binational (Germany and Austria), two-arm, randomized, controlled, post-market study. Study outcome(s) Primary end-point is the modified Rankin Score shift analysis 90 days (±14) after stroke. Secondary end-points are excellent neurological outcomes (modified Rankin Score ≤ 1), good neurological outcomes (modified Rankin Score ≤ 2 or National Institutes of Health Stroke Scale improvement ≥ 10), difference between predicted infarct volume and actual core infarct volume (computed tomography or magnetic resonance imaging) at 30 (±6) h post-ictus, successful recanalization (thrombolysis in cerebral infarction score 2b or 3), functional health status 90 (±14) days after stroke (European Quality of Life-5 Dimensions) as well as common safety endpoints (adverse event, serious adverse event, symptomatic intracranial haemorrhage at 30 (±6) h, death, or dependency). Discussion Whether mechanical thrombectomy in patients with acute ischemic stroke who are not eligible for intravenous thrombolysis with recombinant tissue plasminogen activator improves clinical outcomes is unclear. ‘Thrombectomy in patients ineligible for iv tPA’ may change clinical practice by providing evidence of an effective and safe treatment for such patients.
Market Timing With Moving Averages
Authors: Glabadanidis Paskalis 
Published: June 2015

AbstractI present evidence that a moving average (MA) trading strategy has a greater average return and skewness as well as a lower variance compared to buying and holding the underlying asset using monthly returns of value‐weighted US decile portfolios sorted by market size, book‐to‐market, and momentum, and seven international markets as well as 18,000 individual US stocks. The MA strategy generates risk‐adjusted returns of 3–7% per year after transaction costs. The performance of the MA strategy is driven largely by the volatility of stock returns and resembles the payoffs of an at‐the‐money protective put on the underlying buy‐and‐hold return. Conditional factor models with macroeconomic variables, especially the default premium, can explain some of the abnormal returns. Standard market timing tests reveal ample evidence regarding the timing ability of the MA strategy.
Where hearing starts: the development of the mammalian cochlea
Authors: Basch Martin L. , Brown Rogers M. , Jen Hsin‐I , Groves Andrew K. 
Published: June 2015

AbstractThe mammalian cochlea is a remarkable sensory organ, capable of perceiving sound over a range of 1012 in pressure, and discriminating both infrasonic and ultrasonic frequencies in different species. The sensory hair cells of the mammalian cochlea are exquisitely sensitive, responding to atomic‐level deflections at speeds on the order of tens of microseconds. The number and placement of hair cells are precisely determined during inner ear development, and a large number of developmental processes sculpt the shape, size and morphology of these cells along the length of the cochlear duct to make them optimally responsive to different sound frequencies. In this review, we briefly discuss the evolutionary origins of the mammalian cochlea, and then describe the successive developmental processes that lead to its induction, cell cycle exit, cellular patterning and the establishment of topologically distinct frequency responses along its length.
Assessment of maternal Doppler parameters of ophthalmic artery in fetuses with growth restriction in the third trimester of pregnancy: A case–control study
Authors: Melo Nayana Alves De Brito , Araujo Júnior Edward , Helfer Talita Micheletti , Caetano Ana Carolina Rabachini , Zamarian Ana Cristina Perez , Moron Antonio Fernandes , Diniz Angélica Lemos Debs , Nardozza Luciano Marcondes Machado 
Published: June 2015

AbstractAimThe aim of this study was to assess the Doppler parameters of the ophthalmic artery of pregnant women carrying fetuses with growth restriction (FGR) compared with normal fetuses.Material and MethodsA prospective cross‐sectional study was conducted with 120 pregnant women (60 FGR and 60 normal fetuses) between 32 and 40 weeks of gestation. FGR diagnosis was based on an estimated fetal weight below the 10th percentile of the Hadlock curve. Ophthalmic artery Doppler images were obtained with a linear transducer, with color Doppler examination of the region medial to the optic nerve. The following indices were obtained: pulsatility index, resistance index, peak systolic velocity, second peak velocity (P2), end diastolic velocity, and P2 / peak systolic velocity ratio. The Mann–Whitney U‐test and Student's t‐test were used to compare the groups with regard to quantitative variables, and the χ2‐test was used for categorical variables.ResultsPulsatility index and resistance index were significantly lower in pregnant women with FGR than in those with normal fetuses, with P < 0.001 in both indices. P2 and end diastolic velocity were significantly higher in pregnant women with FGR than in those with normal fetuses (P = 0.002 and P = 0.004, respectively). The P2 / peak systolic velocity ratio was significantly higher in the FGR group than in the control group (P < 0.001). In FGR subgroups, with (17 fetuses) and without (43 fetuses) uterine artery Doppler abnormalities, no significant changes were observed between the groups.ConclusionIn the third trimester of pregnancy, we observed significant differences in the ophthalmic artery Doppler parameters of pregnant women with FGR compared with those with normal fetuses.
From diamonds to black stone; myth to reality: Acute kidney injury with paraphenylene diamine poisoning
Authors: Naqvi Rubina , Akhtar Fazal , Farooq Uzma , Ashraf Sumaira , Rizvi Syed Adibul Hasan 
Published: June 2015

AbstractAimWe report here, a case series of patients with acute kidney injury (AKI) after ingestion of paraphenylene diamine (PPD) a derivative of analine. It is used as a colouring agent to dye hair, fur and plastic and in photographic films.MethodsSubjects for the study reported here comprised a cohort of 100 patients coming to this institution with AKI following PPD poisoning. AKI was defined according to RIFLE criteria and PPD poisoning on the basis of history and presenting features. All patients had normal sized kidneys on ultrasonography and no previous co‐ morbidity.ResultsOne hundred patients with AKI after PPD exposure were brought to this institute between May 2010 and February 2015. Among these, 56 were females, with mean age of 23.11 ± 7.94 years. Cause of AKI was toxic rhabdomyolysis as indicated by marked rise in muscle enzymes with mean lactate dehydrogenase and creatinine phosphokinase levels of 6665.22 ± 6272.04 and 194 486.66 ± 301 905.80, respectively. Hepatotoxicity with raised aspartate aminotransferase and alanine aminotransferase was a main feature of the studied population. Renal replacement was required in 97% of patients. Complete renal recovery was observed in 77 patients, while 16 died during the acute phase of illness. Respiratory failure and recurrent hyperkalaemia were the main causes of mortality.ConclusionEasy availability and low cost of PPD has lead to a remarkable increase in the use of this substance, especially for suicidal purposes. Awareness of its effects among health professionals, as well as at a societal and government level, is needed at this time.
BAHD or SCPL acyltransferase? What a dilemma for acylation in the world of plant phenolic compounds
Authors: Bontpart Thibaut , Cheynier Véronique , Ageorges Agnès , Terrier Nancy 
Published: June 2015

SummaryPhenolic compounds are secondary metabolites involved in several plant growth and development processes, including resistance to biotic and abiotic stresses. The biosynthetic pathways leading to the vast diversity of plant phenolic products often include an acylation step, with phenolic compounds being the donor or acceptor molecules. To date, two acyltransferase families using phenolic compounds as acceptor or donor molecules have been described, with each using a different ‘energy‐rich’ acyl donor. BAHD‐acyltransferases, named after the first four biochemically characterized enzymes of the group, use acyl‐CoA thioesters as donor molecules, whereas SCPL (Serine CarboxyPeptidase Like)‐acyltransferases use 1‐O‐β‐glucose esters. Here, common and divergent specifications found in the literature for both enzyme families were analyzed to answer the following questions. Are both acyltransferases involved in the synthesis of the same molecule (or same group of molecules)? Are both acyltransferases recruited in the same plant? How does the subcellular localization of these enzymes impact metabolite trafficking in plant cells?
Successful treatment by coil embolization for infantile hemangioma with Kasabach–Meritt syndrome of newborn
Authors: Tezuka Mari , Ohta Masaaki , Ochi Fumihiro , Chisaka Toshiyuki , Higaki Takashi , Ishii Eiichi 
Published: June 2015

AbstractInfantile hemangioma (IH) is the most common tumor of infancy, and it sometimes associated with Kasabach–Meritt syndrome (KMS) characterized by anemia, intraperitoneal hemorrhage secondary to rupture, coagulopathy, jaundice, and vascular malformations involving the brain, skin, gut, and other organs. Here, we report two newborn patients having IH with KMS at birth. The first patient had a giant hemangioma in the liver, which was successfully treated with i.v. corticosteroid and coil embolization. The second patient had a large hemangioma of the right axillary region, which was also successfully treated with i.v. corticosteroid, beta‐blocker, coil embolization and local irradiation. All symptoms were controlled without any side‐effects in both patients. According to these findings, combination therapy including coil embolization and corticosteroid is effective for IH patients with KMS. The indications for and timing of coil embolization should be determined further cases have been accumulated.
A class of Stein‐rules in multivariate regression model with structural changes
Authors: Chen Fuqi , Nkurunziza Sévérien 
Published: June 2015

AbstractIn this paper, we consider an estimation problem of the matrix of the regression coefficients in multivariate regression models with unknown change‐points. More precisely, we consider the case where the target parameter satisfies an uncertain linear restriction. Under general conditions, we propose a class of estimators that includes as special cases shrinkage estimators (SEs) and both the unrestricted and restricted estimator. We also derive a more general condition for the SEs to dominate the unrestricted estimator. To this end, we extend some results underlying the multidimensional version of the mixingale central limit theorem as well as some important identities for deriving the risk function of SEs. Finally, we present some simulation studies that corroborate the theoretical findings.
Look‐back study on recipients of Parvovirus B19 (B19V) DNA‐positive blood components
Authors: Juhl D. , Özdemir M. , Dreier J. , Görg S. , Hennig H. 
Published: June 2015

Background and ObjectivesTo assess the relevance of Parvovirus B19 (B19V) DNA at low to intermediate concentrations in blood donors for the recipients of their blood components.Material and MethodsWe studied recipients of B19V DNA‐positive blood components [red blood cell concentrates (RBCs), pooled platelet concentrates and fresh frozen plasma]. This included archived pretransfusion samples as well as follow‐up samples investigated by ELISA or NAT and genome sequence analysis.ResultsIn 132 out of 424 recipients, we could detect no anti‐B19V IgG before transfusion. In 67 out of 132 sero‐negative recipients, a follow‐up sample was available. Sixty‐five of these received blood components from donors with <104 IU B19V DNA/ml plasma and had no evidence of transfusion‐transmitted (TT)‐B19V infection. Homology in genome sequences in donor and recipient provided evidence for a TT‐B19V infection in two recipients. Both patients received RBC containing 3·4 × 106 and 1·8 × 104 IU B19V DNA/ml plasma, respectively. The anti‐B19V IgG titres in the donors were 2 and 76 IU/ml plasma, respectively. The antibodies in the second donor were directed against capsid proteins and are thus considered as potential neutralizing antibodies.ConclusionsTT‐B19V infections through blood components with low (<104 IU/ml plasma) B19V DNA concentrations did not occur in our study. One of the TT‐B19V infections occurred from RBC with intermediate B19V DNA concentration despite the presence of potential neutralizing antibodies in the donor, but its clinical significance was low.
Motor units in the human medial gastrocnemius muscle are not spatially localized or functionally grouped
Authors: Héroux Martin E. , Brown Harrison J. , Inglis J. Timothy , Siegmund Gunter P. , Blouin Jean‐Sébastien 
Published: June 2015

Key points
Human medial gastrocnemius (MG) motor units (MUs) are thought to occupy small muscle territories or regions, with low‐threshold units preferentially located distally.
We used intramuscular recordings to measure the territory of muscle fibres from MG MUs and determine whether these MUs are grouped by recruitment threshold or joint action (ankle plantar flexion and knee flexion).
The territory of MUs from the MG muscle varied from somewhat localized to highly distributed, with approximately half the MUs spanning at least half the length and width of the muscle. There was also no evidence of regional muscle activity based on MU recruitment thresholds or joint action.
The CNS does not have the means to selectively activate regions of the MG muscle based on task requirements.
AbstractHuman medial gastrocnemius (MG) motor units (MUs) are thought to occupy small muscle territories, with low‐threshold units preferentially located distally. In this study, subjects (n = 8) performed ramped and sustained isometric contractions (ankle plantar flexion and knee flexion; range: ∼1–40% maximal voluntary contraction) and we measured MU territory size with spike‐triggered averages from fine‐wire electrodes inserted along the length (seven electrodes) or across the width (five electrodes) of the MG muscle. Of 69 MUs identified along the length of the muscle, 32 spanned at least half the muscle length (≥ 6.9 cm), 11 of which spanned all recording sites (13.6–17.9 cm). Distal fibres had smaller pennation angles (P < 0.05), which were accompanied by larger territories in MUs with fibres located distally (P < 0.05). There was no distal‐to‐proximal pattern of muscle activation in ramp contraction (P = 0.93). Of 36 MUs identified across the width of the muscle, 24 spanned at least half the muscle width (≥ 4.0 cm), 13 of which spanned all recording sites (8.0–10.8 cm). MUs were not localized (length or width) based on recruitment threshold or contraction type, nor was there a relationship between MU territory size and recruitment threshold (Spearman's rho = −0.20 and 0.13, P > 0.18). MUs in the human MG have larger territories than previously reported and are not localized based on recruitment threshold or joint action. This indicates that the CNS does not have the means to selectively activate regions of the MG muscle based on task requirements.
Complete Genome Sequence of a Classical Swine Fever Virus Isolate Belonging to a New Subgenotype, 2.1c, from Guangxi Province, China
Authors: Shao Weixing , Huang Yaohua , Liu Shuang , Wu Faxing , Zhang Zhi , Dong Yaqin , Li Xiaocheng 
Published: June 2015

ABSTRACT
The complete genome sequence of a field isolate of classical swine fever strain (CSFV), GXF29/2013, was determined in this study. This strain was originally isolated from infected pigs in Guangxi Province, China. The most significant difference in the amino acid sequence of the polyprotein from subgenotypes 2.1a and 2.1b is an SPA→APV amino acid substitution at positions 88 and 90 in the E2 protein.
Complete Genome Sequence of Rat Cytomegalovirus Strain ALL-03 (Malaysian Strain)
Authors: Balakrishnan Krishnan Nair , Abdullah Ashwaq Ahmed , Camalxaman Siti Nazrina , Quah Yi Wan , Abba Yusuf , Hani Homayoun , Loh Hwei San , Kamal Farina Mustaffa , Zeenathul Nazariah Allaudin , Aini Ideris , Omar A. R. , Noordin Mohamed Mustapha , Mohd Azmi Mohd Lila 
Published: June 2015

ABSTRACT
The complete genome sequence of the ALL-03 strain of rat cytomegalovirus (RCMV) has been determined. The RCMV genome has a length of 197,958 bp and is arranged as a single unique sequence flanked by 504-bp terminal direct repeats. This strain is closely related to the English strain of RCMV in terms of genetic arrangement but differs slightly in size.
Draft Whole-Genome Sequences of 10 Enterotoxigenic Escherichia coli Serogroup O6 Strains
Authors: Pattabiraman Vaishnavi , Bopp Cheryl A. 
Published: June 2015

ABSTRACT

Enterotoxigenic
Escherichia coli
(ETEC) is an important cause of diarrhea in children under the age of 5 years and in adults living in developing countries, as well as in travelers to these countries. In this announcement, we release the draft whole-genome sequences of 10 ETEC serogroup O6 strains.
Draft Genome Sequence of a
Halorubrum
H3 Strain Isolated from the Burlinskoye Salt Lake (Altai Krai, Russia)
Authors: Rozanov Aleksey S. , Bryanskaya Alla V. , Malup Tatiana K. , Kotenko Anastasia V. , Peltek Sergey E. 
Published: June 2015

ABSTRACT

A
Halorubrum
H3 strain was isolated from a water and silt sample from Burlinskoye Lake (Altai Krai, Russia, 53°8′19″N 78°24′27″E). According to 16S rRNA sequences, this strain is most closely related to
Halorubrum saccharovorum
. The completely sequenced and annotated genome is 3,282,373 bp and contains 3,237 genes.
Genome Sequence of the Potato Plant Pathogen Dickeya dianthicola Strain RNS04.9
Authors: Raoul des Essarts Yannick , Mondy Samuel , Hélias Valérie , Faure Denis 
Published: June 2015

ABSTRACT

Dickeya dianthicola
is one of the causative agents of soft rot and blackleg diseases, which are currently identified in European countries in a wide range of crops. Here, we report the draft genome sequence of
D. dianthicola
strain RNS04.9, which was isolated from a potato plant with blackleg symptoms in 2004.
Draft Genome Sequence of the Bacterium Lysobacter capsici X2-3, with a Broad Spectrum of Antimicrobial Activity against Multiple Plant-Pathogenic Microbes
Authors: Yi Jing-Li , Wang Jing , Li Qun , Liu Zhao-xia , Zhang Li , Liu Ai-Xin , Yu Jin-Feng 
Published: June 2015

ABSTRACT

Lysobacter capsici
strain X2-3 was isolated from the wheat rhizosphere in China and exhibits a remarkable capacity to inhibit the growth of multiple pathogens. Here, we report the draft genome sequence of
L. capsici
strain X2-3 in China.
Draft Genome Sequence of Hydrocarbon-Degrading Pseudomonas putida Strain KG-4, Isolated from Soil Samples Collected from Krishna-Godavari Basin in India
Authors: Dawar Chhavi , Aggarwal Ramesh K. 
Published: June 2015

ABSTRACT

We report here the 5.58-Mb draft genome of
Pseudomonas putida
strain KG-4 obtained from the oil fields of the Krishna-Godavari basin, Andhra Pradesh, India. The genome sequence is expected to facilitate identification and understanding of genes associated with hydrocarbon metabolism, which can help in developing strategies for managing oil spills and bioremediation.
Genome Sequence of Anoxybacillus flavithermus Strain AK1, a Thermophile Isolated from a Hot Spring in Saudi Arabia
Authors: Khalil Amjad , Sivakumar Neelamegam , Qarawi Sami 
Published: June 2015

ABSTRACT

Anoxybacillus flavithermus
strain AK1 was isolated from Al-Ain Alhara, a thermal hot spring located 50 km southeast of the city of Gazan, Saudi Arabia (16°56ʹN, 43°15ʹE). The sequenced and annotated genome is 2,630,664 bp and encodes 2,799 genes.
Bovine Staphylococcus aureus Secretes the Leukocidin LukMF′ To Kill Migrating Neutrophils through CCR1
Authors: Vrieling M. , Koymans K. J. , Heesterbeek D. A. C. , Aerts P. C. , Rutten V. P. M. G. , de Haas C. J. C. , van Kessel K. P. M. , Koets A. P. , Nijland R. , van Strijp J. A. G. 
Published: June 2015

ABSTRACTAlthoughStaphylococcus aureusis best known for infecting humans, bovine-specific strains are a major cause of mastitis in dairy cattle. The bicomponent leukocidin LukMF′, exclusively harbored byS. aureusof ruminant origin, is a virulence factor associated with bovine infections. In this study, the molecular basis of the host specificity of LukMF′ is elucidated by identification of chemokine receptor CCR1 as its target. Bovine neutrophils, the major effector cells in the defense against staphylococci, express significant cell surface levels of CCR1, whereas human neutrophils do not. This causes the particular susceptibility of bovine neutrophils to pore formation induced by LukMF′. BovineS. aureusstrains produce high levels of LukMF′in vitro. In culture supernatant of the mastitis field isolate S1444, LukMF′ was the most important cytotoxic agent for bovine neutrophils. In a fibrin gel matrix, the effects of thein situsecreted toxins on neutrophils migrating towardS. aureuswere visualized. Under these physiologicalex vivoconditions, bovineS. aureusS1444 efficiently killed approaching neutrophils at a distance through secretion of LukMF′. Altogether, our findings illustrate the coevolution of pathogen and host, provide new targets for therapeutic and vaccine approaches to treat staphylococcal diseases in the cow, and emphasize the importance of staphylococcal toxins in general.IMPORTANCEThis study explains the mechanism of action of LukMF′, a bicomponent toxin found in bovine lineages ofS. aureusthat is associated with mastitis in cattle. At a molecular level, we describe how LukMF′ can specifically kill bovine neutrophils. Here, we demonstrate the contribution of toxins in the determination of host specificity and contribute to the understanding of mechanisms of coevolution of pathogen and host. Our study provides new targets that can be used in therapeutic and vaccine approaches to treat staphylococcal diseases in the cow. We also demonstrate the importance of toxins in specific elimination of immune cells, which has broader implications, especially in human infections.