bluuebunny/crossref_metadata_2025_split huggingface dataset:
„Gibt es einen Zusammenhang zwischen Hitzeperioden und dem
psychiatrischen Notfall in einer Zentralen Notaufnahme?“
Authors: Kirchner Heribert , Ullrich Heiko , Hulsmans Nik , Brzoska Patrick , Pajonk Frank-Gerald B. 
Published: July 2024

Zusammenfassung
Ziel der Studie Es gibt Hinweise, dass sich der Klimawandel, verbunden mit
einer Zunahme der Häufigkeit und Schwere von Hitzeperioden, negativ auf die
psychische Gesundheit auswirkt. Das Ziel dieser Studie war es, mögliche
Zusammenhänge zwischen hohen Temperaturen und der Inanspruchnahme einer ZNA
durch Menschen mit psychischen Erkrankungen zu untersuchen.
Methodik Es wurde eine retrospektive Analyse aller psychiatrischen
Notfallpatienten im Zeitraum von 2015 bis 2022 (N=15478) durchgeführt und den
lokalen Temperaturdaten gegenübergestellt.
Ergebnisse Während Hitzeperioden stellten sich mehr psychiatrische
Notfallpatienten in der ZNA vor.
Schlussfolgerung Bis auf eine erhöhte Vorstellungsrate während
Hitzeperioden konnten in unserer Stichprobe keine weiteren signifikanten
Auswirkungen von Hitze auf psychiatrische Notfälle gefunden werden. Dies steht
im Widerspruch zu Ergebnissen anderer Studien. Andere systemische Einflüsse, wie
die Inanspruchnahme der ZNA währen der Covid-19-Pandemie, konnten die Ergebnisse
modifizieren.
Shared Access to Adults' Patient Portals: A Secret Shopper Exercise
Authors: Wachenheim Deborah , Hurwitz Isabel , Dukhanin Vadim , Wolff Jennifer L. , DesRoches Catherine M. 
Published: July 2024

Abstract
Background Millions of Americans manage their health care with the help of a trusted individual. Shared access to a patient's online patient portal is one tool that can assist their care partner(s) in gaining access to the patient's health information and allow for easy exchange with the patient's care team. Shared access provides care partners with a validated and secure method for accessing the patient's portal account using their own login credentials. Shared access provides extra privacy protection and control to the patient, who designates which individuals can view their record. It also reduces confusion for the care team when interacting with the care partner via the portal. Shared access is underutilized among adult patients' care partners.
Objectives Investigate the process of granting or receiving shared access at multiple health care organizations in the United States to learn about barriers and facilitators experienced by patients and care partners.
Methods The Shared Access Learning Collaborative undertook a “Secret Shopper” exercise. Participants attempted to give or gain shared access to another adult's portal account. After each attempt they completed a 14-question survey with a mix of open- and closed-ended questions.
Results Eighteen participants attempted to grant or receive shared access a total of 24 times. Fifteen attempts were successful. Barriers to success included requiring paper forms with signatures, lack of knowledgeable staff, lack of access to technical support, and difficult-to-navigate technology. Facilitators included easy-to-navigate online processes and accessible technical help. Participants who were successful in gaining shared access reported feeling more informed and able to engage in shared decision-making.
Conclusion The outcomes of our secret shopper exercise underscore the importance of collaboration aimed at learning from diverse encounters and disseminating the best practices. This is essential to address technical, informational, and organizational obstacles that may impede the widespread and accessible adoption of shared access.
Microwave-Assisted Synthesis of Fluorescent 8-Aryl-7-deazaguanines
Authors: Dhimitruka Ilirian , Cheney Hunter B. D. , Zevitz Elise S. , Herbrechtsmeier Madeline G. 
Published: July 2024

AbstractMicrowave-assisted conditions were adapted to our previously published synthesis of 8-aryl-7-deazaguanines via cyclocondensation of phenacyl bromides with 2,4-diamino-6-hydroxypyrimidine in refluxing 1,4-dioxane. Upon microwave irradiation at 150–225 °C, 8-aryl-7-deazaguanines were obtained in high yield above 90% and within 15–60 min, compared to the 24–72 h that are required under reflux conditions. Three new fluorescent 8-heteroaryl-7-deazaguanines were additionally produced and characterized confirming our hypothesis that compounds of this class typically exhibit fluorescence properties, regardless of the aryl substituent.
Regio- and Chemoselective Synthesis of 4,6-Dithia-1,2,9-triazaspiro[4.4]non-2-en-8-ones through an Ultrasound-Promoted One-Pot Sequential Pseudo-Five-Component Reaction
Authors: Alizadeh Abdolali , Chelebari Ebrahim Amir , Rezaiyehraad Reza 
Published: July 2024

AbstractSpiro-heterocycles have attracted significant interest due to their unique biological properties with fewer side effects compared to traditional drugs. Herein, a novel method is reported for the synthesis of a series of spiro-heterocycles possessing a quinoline motif. The strategy utilizes rhodanine derivatives, hydrazonoyl chlorides, and 2-chloroquinoline-3-carbaldehyde, and proceeds via a one-pot sequential pseudo-five-component reaction. The reactions are found to proceed in a regioselective and chemoselective manner.
Evaluation of Salvia officinalis in the Treatment of Acetic Acid-induced Ulcerative Colitis in a Rat Model
Authors: Shahriarirad Reza , Seifbehzad Sarvin , Erfani Amirhossein , Nekouei Fatemeh , Ashkani-Esfahani Soheil , Hosseinzadeh Masood , Tanideh Nader , Koohi-Hosseinabadi Omid , Sarkari Bahador 
Published: July 2024

Abstract
Introduction Ulcerative colitis (UC) is an inflammatory bowel disease that causes long-lasting inflammation and ulcers within the digestive tract. This study aims to determine the histochemical alteration of Salvia officinalis (sage), an anti-inflammatory and antioxidant herbal agent on UC.
Materials and Methods The disease was induced in 37 Sprague-Dawley rats with 2 mL of 3% acetic-acid (AA) enema. The rats were divided into five groups: a control group (AA), two 5-aminosalicylic (5-ASA) groups treated either orally (AO) or rectally (AR) with a dose of 100 mg/kg, and two salvia groups treated with 300mg/kg salvia orally (SO) or rectally (SR). Histopathological analyses of the colon were done on day 7, and markers such as C-reactive protein (CRP), superoxide dismutase (SOD), and complete blood count were measured.
Result In macroscopic evaluation, the AO group demonstrated the lowest involvement, followed by the SO, SR, AR, and AA groups, respectively (p = 0.01). There was no significant difference between the SO and AO groups (p = 0.10), and the SR and AR groups (p = 0.58). Regarding microscopic histopathological findings, the AO and SO group demonstrated the most satisfactory results, with no significant difference between the AO versus SO, and AR versus SR groups. Inflammation was resolved in all of the AO and SO subjects.
Conclusion Salvia can be beneficial in the treatment course of UC by inhibiting inflammatory responses, increasing the growth and viability of intestinal mucosa, and its antioxidant effects. Therefore, we propose the prescription of salvia as an adds-on or alternative therapy in the management of UC.
Clinical Characterization, Transmissibility, and Seroconversion of SARS-CoV-2 Infection in Children (before the Start of Vaccination) in the Barcelona Metropolitan Region (Spain)
Authors: Garcia-Garcia Juan José , Fumadó Victoria , Pons-Tomàs Gemma , Hernández-García María , Melé-Casas Maria , de-Sevilla Mariona F. , Launes Cristian , Girona-Alarcón Mònica , Barnés María Ríos , Bassat Quique , Ajanovic Sara , Cubells Marta , Claverol Joana , Penela-Sánchez Daniel , Jou Cristina , Monsonis Manuel , Esteva Cristina , Fassanella Assumpta , Cuadras Daniel , Muñoz-Almagro Carmen , Jordan Iolanda , Fortuny Claudia 
Published: July 2024

Abstract
Objective Analyzing the clinical and microbiological characteristics of coronavirus disease 2019 (COVID-19) infection in children seems essential to determine their role in the etiopathogenesis of the disease.
Methods A prospective, longitudinal, and observational study, including children with severe acute respiratory syndrome coronavirus-2 infection, in the Barcelona Metropolitan Region (Spain), was performed. The recruitment pathways were: (1) children who attended a summer school and were included in an active surveillance study and (2) children who were visited in the Emergency Department of Hospital Sant Joan de Déu with symptoms. Close contacts with positive polymerase chain reaction (PCR) results were also included. The children recruited were followed up for 5 weeks. Evaluation of participants included a questionnaire for COVID-19 symptoms, nasopharyngeal swabbing for real-time PCR at 0, 7, and 14 days (weekly repeated up to week 5 if it resulted positive at 14 days), and serology testing at the recruitment and at the fifth week of follow-up.
Results A total of 90 children were recruited, of which 32% were asymptomatic. Transmission was studied in 70/90 children, and in 12 cases (17%), transmission to other children or adults was observed. No clinical or epidemiological differences were found between children who transmitted and those who did not. At the end of the follow-up, 11% of nasopharyngeal PCR remained positive. The serological response was studied in 73/90 children, and 80.82% of children seroconverted.
Conclusion No differences in epidemiological characteristics were found between children who transmitted and those who did not. PCR can be persistently positive for more than 5 weeks. The majority of patients who suffer from the disease produce antibodies against it.
Clinical and Radiologic Outcomes after Cryoablation of Desmoid Tumors
Authors: Bergin Brad , Newman Lucas Killian , Przybojewski Stefan 
Published: July 2024

Abstract
Purpose This study aims to evaluate the impact of cryoablation on patients with desmoid tumors, considering both pain and functional impairment. Cryoablation has emerged as a promising intervention, primarily recognized for its ability to reduce radiological evidence of the neoplasm. However, the focus of this research is on assessing the clinical outcomes, recognizing the importance of improving patient-reported symptoms as additional evidence is required in this area to strengthen previous findings.
Methods A retrospective study of 18 patients treated with cryoablation for desmoid tumors were included in this study. The evaluation of clinical status involved structured interviews to capture changes in pain and functional impairment. Pain scores and functional impairment scores were recorded on a 10-point Likert scale before and after the treatment. The correlation between these clinical findings and imaging was a key aspect of the investigation.
Results Following cryoablation treatment, the average pain scores exhibited a notable decrease of 4.75 points on the 10-point Likert scale. Similarly, functional impairment scores demonstrated a significant average decrease of 4.0 points. Additionally, there was an overall decrease in viable tumor volume after ablation, correlating with the above findings.
Conclusion This study provides evidence that cryoablation is effective in achieving clinically significant improvement in patients with desmoid tumors. While the reduction in radiological evidence is recognized, the emphasis of this study was on patient-reported outcomes, particularly in pain and functional impairment. These findings underscore that cryoablation is a valuable intervention in the comprehensive management of desmoid tumors improving overall quality of life.
Open Neck Lift: Surgical Technique and A Clinical Classification for Cervical Rejuvenation
Authors: Khan Muhammad Adil Abbas , Ma Yangmyung , Dargan Dallan , Kelemen Noemi , Bhatti Dujanah , Riaz Armaan , Riaz Muhammad 
Published: July 2024

AbstractCareful evaluation of the neck and its relationship to the lower third of the face is fundamental to provide appropriate recommendations for procedures. The authors propose a modified Baker “clinical” classification as a more reliable and reproducible evaluative basis for the treatment of the aging neck. A total of 450 patients underwent procedures for cervical rejuvenation between December 2012 and December 2022 by the senior author. These included 9 cases of neck liposuction, 6 isolated neck lifts, 15 minimal access cranial suspension face lifts, 94 face lifts with open neck lifts, and 326 extended R-face and neck lifts. The male-to-female ratio was 1:20. The mean patient age was 59.1 years and the mean follow-up was 14 months (range 11.5–20 months). From the data, a modified Baker clinical classification for the aging neck was formulated along with recommendations for possible solutions. Ninety-four percent of the patients expressed high satisfaction on the Owsley Facelift Satisfaction Survey at 1-year follow-up. The complication rate was 1.78% (8 patients), including 1 hematoma, 1 skin edge necrosis (1 cm), 1 slow healing site (postauricular), 3 limited postauricular/earlobe scar revisions, and 2 mild contour irregularities. Cervical rejuvenation can be achieved by a spectrum of interventions and approaches. A comprehensive preoperative assessment and a clinical neck lift classification are the keys to selecting the correct surgical technique for achieving reliable and consistent results. The authors propose a pragmatic approach for both isolated and integrated neck lift procedures with excellent aesthetic outcomes and minimal complications.
Efficacy and Safety of mFOLFOX-6 in Advanced Gastric Cancer: A Prospective Observational Study
Authors: Patel Amrith B. , Goel Varun , Joga Srujana , Koyyala V.P.B. , Goyal Sumit , Doval Dinesh C. , Batra Ullas , Talwar Vineet 
Published: July 2024

Background The widespread use of oxaliplatin plus infusional 5-fluorouracil (5-FU) and folinic acid (FOLFOX) in advanced gastric cancers is mainly based on clinical trials conducted at Western/European countries. The prospective data on efficacy and safety of FOLFOX in advanced gastric cancer is lacking from the developing countries. In this prospective observational study, we evaluated the efficacy and toxicity of mFOLFOX-6 in patients with advanced gastric or gastroesophageal junction (GEJ) adenocarcinomas, as first-line palliative chemotherapy.
Methods Patients with previously untreated metastatic adenocarcinoma of stomach/GEJ, received mFOLFOX-6 (2 hours infusion of oxaliplatin [85 mg/m2] and folinic acid [400 mg/m2], followed by fluorouracil 400 mg/m2 intravenous push, then a 46-hour continuous infusion of 5-FU [2,400 mg/m2]). Cycles were repeated every 2 weeks. The patients were prospectively followed up for response rates and toxicity.
Results Sixty-six patients were included in the study with a median age of 57 years. Sixty-two patients were evaluable for response. The overall response rate was 53%, with a disease control rate (overall response and stable disease) of 81.8%. The median progression-free survival was 6 months (95% confidence interval [CI] 5.2–6.7 months) and the median overall survival was 11.5 months (95% CI 9.0–13.9 months). Ascites at presentation and more than one site of metastasis are associated with significantly lower survival on the log-rank test. Gastrointestinal and hematological toxicities were predominant, with rates of grade 3 to 4 nausea/vomiting (13.6%), anemia (15.1%), and neutropenia (13.6%). Among other toxicities, neurosensory toxicities were common. Four (6%) patients had grade 3 peripheral neuropathy.
Conclusion mFOLFOX-6 is an active and well-tolerated chemotherapy regimen in advanced adenocarcinoma of stomach/GEJ. This regimen has similar response rates and treatment outcomes with lesser grade 3 or 4 toxicities than that of triplet regimens compared to historical studies.
Psychiatric Manifestations Caused by Mycoplasma pneumoniae Encephalitis Mimicking Autoimmune Encephalitis
Authors: Kentab Amal Y. , AlOlean Thekra 
Published: July 2024

AbstractA significant etiological factor for upper respiratory tract infections and community-acquired pneumonia is Mycoplasma pneumoniae. The incidence of extrapulmonary neurological problems in infected patients has been shown to range from 0.1 to 7%, often manifesting within a timeframe of 2 to 14 days following the onset of respiratory symptoms. Acute disseminated encephalomyelitis, Guillain–Barré syndrome, and transverse myelitis are among the immune-mediated illnesses encompassed under the syndrome. A 3-year-old male child exhibited symptoms of acute encephalopathy and behavioral disruption subsequent to an infection caused by M. pneumoniae. He presented with irritability, sleep disturbance, slurred speech, increased appetite, episodes of unresponsiveness, moving in circles, staring, and laughing episodes lasting for up to 15 to 30 minutes over a week. He lost his previous toilet training. Abnormal jerks were noted while awake and asleep. Symptoms were preceded by exposure to vague febrile illness 3 weeks prior to presentation. The patient's brain magnetic resonance imaging was normal. Electroencephalography showed a slow background with no epileptiform discharges. Cerebrospinal fluid analysis and polymerase chain reaction for viruses were negative. The workup for autoimmune encephalitis was negative. Mycoplasma serology IgM was detected. Marked improvement was noted after methylprednisolone pulse therapy, intravenous immunoglobulin, valproic acid, and azithromycin. In conclusion, our report serves as a reminder that M. pneumoniae infection is a possible cause of encephalopathy and behavioral disturbance in children. Early recognition and promotion of immunomodulatory and antimicrobial treatment can prevent the affected child from experiencing different levels of long-lasting impairments in cognitive, physical, or visual abilities.
Application of Using Gore Preclude MVP Dura Substitute for Intraoperative Durotomy Repair in Lumbar Spine Surgery: Case Series and A Technical Note
Authors: Maki Yoshinori , Kawasaki Toshinari , Nakajima Kota , Ando Mitsushige , Kobayashi Tamaki , Ioroi Yoshihiko , Takayama Motohiro 
Published: July 2024

AbstractDurotomy is an intraoperative complication in lumbar surgery, which can result in refractory cerebrospinal leakage. Therefore, intraoperative durotomy in lumbar surgery should be appropriately repaired. The aim of the study was to describe our method to repair intraoperative durotomy using the Gore Preclude MVP Dura Substitute (MVP). The MVP is an artificial dural substitute of three layers. Its surfaces are composed of expanded polytetrafluoroethylene, and the intermittent layer is made of a proprietary fluoroelastomer. After an incidental durotomy during surgery, the MVP was cut and designed bigger than the size of the durotomy site. The MVP was inserted into the space between the dura and the arachnoid membrane. The MVP was unfolded in the inserted space and fixed to the dura using four nodes of 6–0 nylon yarn. Intraoperative dural repair was achieved, and cerebrospinal fluid leakage did not persist. No complications were observed. Our method to repair intraoperative durotomy using the MVP can be simple and useful.
ESGO Quality Indicators for Surgical Management of Cervical Cancer: An Audit of Compliance of a Tertiary Care Center
Authors: Thiagarajan Monica , Thomas Vinotha , Sebastian Ajit , Thomas Dhanya Susan , Thomas Anitha , Chandy Rachel , Peedicayil Abraham 
Published: July 2024

Objective This article assesses the compliance of surgical management of carcinoma cervix, to the quality indicators for treatment put forth by the European Society of Gynaeacological Oncology (ESGO), at a tertiary care center.
Methods This is a retrospective analysis and audit of data collected from electronic medical records of patients with carcinoma cervix who underwent surgical management in the department of gynecologic oncology from June 1, 2017 to May 31, 2020.
Results Compliance to all 15 quality indicators under 5 categories was assessed. The first two structural indicators were met. The mean number of parametrectomies was 24 and all were operated by a specialist. With regard to targets addressing overall management, only 46% cases were preoperatively planned in multidisciplinary team meetings and 74% met the target of required preop investigations. There was deficiency in recording pertinent intraoperative details and postoperative pathological information. On assessing the quality of surgical care, there were no postoperative urological fistula, but 18% had involved surgical margins, 16% were upstaged postsurgery, and 15% had recurrence within 2 years. All were counseled about fertility-sparing technique when relevant but only 7% had undergone lymph node staging as per recommendations and 51% had received adjuvant chemoradiation.
Conclusion This audit revealed that the department did not meet the ESGO quality standards published in 2020. The department has implemented structural and procedural changes to meet these standards and a plan to continuously assess compliance to the same.
Clinical care ratios for allied health practitioners: an update and implications for workforce planning
Authors: Hearn Cherie , Ross Julie-Anne , Govier Adam , Semciw Adam Ivan 
Published: July 2024

Objective Clinical care ratios are used to quantify and benchmark the activity of allied health professionals. This study aims to review previous recommendations and identify what variables may influence them. Method Data was collected from the core allied health professions (audiology, nutrition and dietetics, occupational therapy, physiotherapy, podiatry, prosthetics and orthotics, psychology, social work and speech pathology) across eight Australian hospitals. Data for 113 staff who were casual or from smaller professions (audiology, podiatry, prosthetics and orthotics and psychology) were excluded due to insufficient numbers for analysis. The remaining data were analysed according to profession, seniority (tiers 1, 2 and 3) and employment status (permanent versus casual staff). A two-way ANOVA was performed to assess the association of clinical care ratios with tier, profession, employment status and gender. Results Data from 1246 staff from the five larger professions at participating hospitals were analysed. There were no interactions between profession and gender (P = 0.185) or employment status (P = 0.412). The relationship between clinical care ratio and profession was modified by tier (interaction term, P = 0.014), meaning that differences in clinical care ratios between professions depended on the tier. Conclusion This research has confirmed that clinical care ratios are a useful tool in workload management and determining staffing levels for allied health professionals. The recommendations from this research provide a starting point that can be finessed with reference to profession, model of care, workforce structure, governance and training requirements. This will lead to increased staff wellbeing and improved patient outcomes.