bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomimetic Structurally Colored Film for High‐Performance Radiative Cooling
Authors: Lin Yiyi , Qin Chaohua , Liang Zixian , Lin Wanying , Wang Jizhuang , Li Dan 
Published: June 2024

AbstractIn recent years, passive radiative cooling has garnered considerable attention as a sustainable thermal regulation without relying on external energy sources, thus mitigating pollutants generation. However, an intrinsic limitation of these cooling systems lies in the reflective glare, often characterized by an ivory or silvery appearance. This drawback limits their practical application, especially where both functional efficiency and aesthetic appeal are pivotal. Herein, a biomimetic approach inspired by Saharan silver ants' thermoregulatory capabilities is adopted. These ants, equipped with distinctive triangular‐shaped hair, maintain body temperature lower than the ambient air. Leveraging insights from this natural model, a reusable silicon template is employed to fabricate a metasurface structural colored film with a triangular prism array structure using thermoplastic polyurethane (TPU) and the phase separation technique. The film demonstrates an average emissivity of 96% within the atmospheric window and an average solar reflectivity of 93%, leading to a maximum temperature reduction of 8.6 °C during daytime and 5.9 °C at night. Furthermore, the film displays stretchability and mechanical resilience, bolstered by the microscale prismatic structure enhancing superhydrophobicity. This work introduces a biomimetic strategy aimed at augmenting thermal emission while reconciling the challenge of achieving visual appealand high radiative cooling performance.
LTBP2 Knockdown Ameliorates Cardiac Fibrosis and Apoptosis via Attenuating NF‐κB Signaling Pathway and Oxidative Stress in Mice with Cardiac Hypertrophy
Authors: Wang Yifeng , Hua Dongxu , Zhao Kun , Xie Qiyang , Wu Xiaoguang , Gao Min , Huang Wanling , Huang Wen , Li Peng , Sheng Yanhui 
Published: June 2024

AbstractAt present, there is no therapeutic approach available to reverse the progression of pathological fibrosis and ventricle chamber stiffening. This study is designed to explore the effects of latent transforming growth factor‐beta‐binding protein 2 (LTBP2) on cardiac fibrosis in hypertrophic cardiomyopathy and the underlying mechanisms. The key differential gene LTBP2 is identified by mRNA sequencing. Ang II‐induced cells and mice are treated with LTBP2 si‐RNA or knockdown adenovirus, respectively, and the indicators of cardiac function, oxidative stress, cardiac fibrosis, apoptosis, and remodeling are examined. The underlying mechanism is elucidated in vitro by oxidative stress and an agonist of nuclear factor‐kappa B (NF‐κB). LTBP2 is upregulated in the cardiac tissue of mice with Ang II‐mediated HF. The knockdown of LTBP2 enhanced cardiac function, attenuated cardiac fibrosis, apoptosis, hypertrophy, and oxidative stress injury, and suppressed NF‐κB expression. These results are validated in vitro. The effects of LTBP2 gene silencing are reversed by either NF‐κB or oxidative stress agonists in vitro. Taken together, these findings suggest that LTBP2 knockdown alleviates HF by inhibiting cardiac fibrosis, apoptosis, and hypertrophy via attenuating NF‐κB signaling pathway and oxidative stress. Thus, targeting LTBP2 may be a novel approach to the treatment of HF.
Development of a New Positron Emission Tomography Imaging Radioligand Targeting RIPK1 in the Brain and Characterization in Alzheimer's Disease
Authors: Bai Ping , Lan Yu , Liu Yan , Mondal Prasenjit , Gomm Ashley , Xu Yulong , Wang Yanli , Wang Yongle , Kang Leyi , Pan Lili , Bagdasarian Frederick A. , Hallisey Madelyn , Lobo Fleur , Varela Breanna , Choi Se Hoon , Gomperts Stephen N. , Wey Hsiao‐Ying , Shen Shiqian , Tanzi Rudolph E. , Wang Changning , Zhang Can 
Published: June 2024

AbstractTargeting receptor‐interacting protein kinase 1 (RIPK1) has emerged as a promising therapeutic stratagem for neurodegenerative disorders, particularly Alzheimer's disease (AD). A positron emission tomography (PET) probe enabling brain RIPK1 imaging can provide a powerful tool to unveil the neuropathology associated with RIPK1. Herein, the development of a new PET radioligand, [11C]CNY‐10 is reported, which may enable brain RIPK1 imaging. [11C]CNY‐10 is radiosynthesized with a high radiochemical yield (41.8%) and molar activity (305 GBq/µmol). [11C]CNY‐10 is characterized by PET imaging in rodents and a non‐human primate, demonstrating good brain penetration, binding specificity, and a suitable clearance kinetic profile. It is performed autoradiography of [11C]CNY‐10 in human AD and healthy control postmortem brain tissues, which shows strong radiosignal in AD brains higher than healthy controls. Subsequently, it is conducted further characterization of RIPK1 in AD using [11C]CNY‐10‐based PET studies in combination with immunohistochemistry leveraging the 5xFAD mouse model. It is found that AD mice revealed RIPK1 brain signal significantly higher than WT control mice and that RIPK1 is closely related to amyloid plaques in the brain. The studies enable further translational studies of [11C]CNY‐10 for AD and potentially other RIPK1‐related human studies.
Mussel‐Derived and Bioclickable Peptide Mimic for Enhanced Interfacial Osseointegration via Synergistic Immunomodulation and Vascularized Bone Regeneration
Authors: Zhou Wei , Liu Yang , Dong Jiale , Hu Xianli , Su Zheng , Zhang Xianzuo , Zhu Chen , Xiong Liming , Huang Wei , Bai Jiaxiang 
Published: June 2024

AbstractInadequate osseointegration at the interface is a key factor in orthopedic implant failure. Mechanistically, traditional orthopedic implant interfaces fail to precisely match natural bone regeneration processes in vivo. In this study, a novel biomimetic coating on titanium substrates (DPA‐Co/GFO) through a mussel adhesion‐mediated ion coordination and molecular clicking strategy is engineered. In vivo and in vitro results confirm that the coating exhibits excellent biocompatibility and effectively promotes angiogenesis and osteogenesis. Crucially, the biomimetic coating targets the integrin α2β1 receptor to promote M2 macrophage polarization and achieves a synergistic effect between immunomodulation and vascularized bone regeneration, thereby maximizing osseointegration at the interface. Mechanical push‐out tests reveal that the pull‐out strength in the DPA‐Co/GFO group is markedly greater than that in the control group (79.04 ± 3.20 N vs 31.47 ± 1.87 N, P < 0.01) and even surpasses that in the sham group (79.04 ± 3.20 N vs 63.09 ± 8.52 N, P < 0.01). In summary, the novel biomimetic coating developed in this study precisely matches the natural process of bone regeneration in vivo, enhancing interface‐related osseointegration and showing considerable potential for clinical translation and applications.
Challenges and Opportunities for Passive Thermoregulation
Authors: Guo Na , Shi Changmin , Warren Natalie , Sprague‐Klein Emily A. , Sheldon Brian W. , Yan Hongjie , Chen Meijie 
Published: June 2024

AbstractThe unsustainable nature of energy‐intensive and environmentally unfriendly traditional air conditioning systems, compacted with recent climate change effects, show an urgent need for more sustainable and efficient thermoregulation solutions. Innovations in passive daytime radiative coolers (PDRCs) and selective solar absorbers (SSAs), which utilize natural resources, the “cold” outer space and “hot” sun from the sky, offer an environmentally friendly and cost‐effective alternative. However, various factors significantly impede the commercial viability of these technologies, such as lack of emphasis on advancements for practical application, the challenge of reversible functionality between PDRCs and SSAs, inconsistent performance evaluation, and the absence of effective mass production strategies. Here current challenges and future development trends of PDRC and SSA‐aided innovation are discussed. Specifically, challenges and opportunities relating to application conditions, evaluation parameter standardization, and strategies are considered for large‐scale production, all of which are critical for realizing the full potential of PDRCs and SSAs.
Protective effects of diversified diets for dietary folate adequacy and serum homocysteine in breastfeeding mothers amid historic drought
Authors: Fujita Masako , Asthana Ananyaa , Wamwere‐Njoroge George 
Published: June 2024

AbstractObjectivesThe United Nations recommends that women consume ≥5 food groups, also known as the minimum dietary diversity score for women (MDD‐W), for nutritional health. This is increasingly unattainable for populations in climate hot zones coping with food insecurity by prioritizing calories over dietary breadth. Breastfeeding mothers may be particularly vulnerable to adverse health impacts of low dietary diversity due to elevated nutritional requirements for lactation. We investigated how the protective effects of MDD‐W for folate adequacy varies by MDD‐W score and mother–infant life history characteristics.MethodsWe conducted a secondary analysis of cross‐sectional data from breastfeeding mothers (n = 228) in northern Kenya, surveyed during the 2006 Horn‐of‐Africa drought. Logistic regression models for adequate dietary folate (and vitamins B12 and B6) and normal homocysteine (folate‐replete status) evaluated the effect of MDD‐W alone and in interaction with infant/maternal characteristics.ResultsMDD‐W (as ordinal or dichotomous variable) was positively associated with adequate folate (and vitamin B12). Having male infant was inversely associated with adequate dietary folate. MDD‐W was generally unassociated with homocysteine. However, there was an interaction between MDD‐W and sex of the infant. Namely, MDD‐W ≥ 3 predicted increased probability of normal homocysteine among mothers with female infants but not male infants.ConclusionsDiets consisting of three or more food groups may protect adequate folate intake for many breastfeeding mothers. More research is needed to establish what level of dietary diversity would protect against hyperhomocysteinemia during breastfeeding and what factors promote or hinder the benefit of diversified diets on maternal folate nutrition.
Cost of agricultural injuries in the United States: Estimates based on surveillance, insurance, and government statistics
Authors: Adhikari Suraj , Wilson Fernando , Rautiainen Risto 
Published: June 2024

AbstractBackgroundAgriculture is a hazardous industry but the frequency and severity of agricultural injuries are not well documented as nonfatal injuries to self‐employed farmers are excluded from national surveillance. The aim of this study was to provide new injury rate and cost estimates in US agriculture.MethodsInjury data were obtained from 2018 to 2020 Farm and Ranch Health and Safety Surveys. Responses from 7,195 farm/ranch operators included injury frequency, medical expense, and lost work time data. These injury rate and cost data were used to estimate national injury costs for self‐employed farmers using Census of Agriculture operator count, injury costs for hired agricultural workers using Bureau of Labor Statistics (BLS) nonfatal injury count, and fatal injury costs using BLS count of fatal injuries.ResultsThe injury rate for self‐employed farmers and ranchers was 15.25 injuries per 100 operators or 11.9 “recordable” injuries per 100 full time equivalent operators (FTE). Average costs for nonfatal injuries were: $10,878 for medical care, $4735 for lost work time, and $15,613 in total per injury case. The total national agricultural injury cost estimate was $11.31 billion per year; 11.3% higher than the earlier benchmark using 1992 data; both in March 2024 dollars. The cost burden was 2.1% of the US national gross farm income and 13.4% of the net farm income in 2019.ConclusionsInjuries result in significant economic losses to farm and ranch operators, their family members, workers, and society. Preventive efforts should be scaled up to reduce the frequency and costs of agricultural injuries.
ACOX1 gain‐of‐function variation in a 10‐years‐old patient responsive to immunomodulating therapy
Authors: Filippi Corinna , Brunetti Sara , Plumari Massimo , Valente Enza Maria , Accorsi Patrizia , Fazzi Elisa Maria 
Published: June 2024

AbstractA heterozygous gain‐of‐function variant in the acyl‐CoA oxidase 1 (ACOX1) gene, c.710A>G (p.Asn237Ser), is known to cause Mitchell syndrome, a very rare progressive disorder characterized by episodic demyelination, sensory polyneuropathy, and hearing loss. Only eight patients have been described so far. A single patient has been treated with intravenous immunoglobulin administration, indicating clinical improvement. In this study, we describe a 10‐year‐old girl carrying the identical mutation, who presented with progressive sensorineural deafness, visual abnormalities, skin ichthyosis, and gait ataxia from infantile age with progressive worsening and loss of walking ability by the age of 10 years. Antioxidant therapies and monthly intravenous immunoglobulin infusions showed excellent clinical results: after 1 year of treatment, the child is now able to walk, run, and jump. We emphasize the importance of early genetic diagnosis since an effective treatment is available for this rare condition.
Brief communication: New method for measuring nitrogen isotopes in tooth dentine at high temporal resolution
Authors: Smith Tanya M. , Ávila Janaína N. , Arora Manish , Austin Christine , Drake Teresa , Kinaston Rebecca , Sudron Emma , Wang Yue , Williams Ian S. 
Published: June 2024

AbstractObjectivesNitrogen isotopes (δ15N) are widely used to study human nursing and weaning ages. Conventional methods involve sampling 1‐mm thick sections of tooth dentine—producing an averaging effect that integrates months of formation. We introduce a novel protocol for measuring δ15N by multicollector secondary ion mass spectrometry (SIMS).Materials and MethodsWe sampled dentine δ15N on a weekly to monthly basis along the developmental axis in two first molars of healthy children from Australia and New Zealand (n = 217 measurements). Nitrogen isotope ratios were determined from measurements of CN− secondary molecular ions in ~35 μm spots. By relating spot position to enamel formation, we identified prenatal dentine, as well as sampling ages over more than 3 years. We also created calcium‐normalized barium and strontium maps with laser ablation‐inductively coupled plasma‐mass spectrometry.ResultsWe found rapid postnatal δ15N increases of ~2‰–3‰, during which time the children were exclusively breastfed, followed by declines as the breastfeeding frequency decreased. After weaning, δ15N values remained stable for several months, coinciding with diets that did not include meat or cow's milk; values then varied by ~2‰ starting in the third year of life. Barium did not show an immediate postnatal increase, rising after a few months until ~1–1.5 years of age, and falling until or shortly after the cessation of suckling. Initial strontium trends varied but both individuals peaked months after weaning.DiscussionDevelopmentally informed SIMS measurements of δ15N minimize time averaging and can be precisely related to an individual's early dietary history.
Guidance for clinical practice using emergency and point‐of‐care ultrasonography
Authors: Kameda Toru , Ishii Hiromoto , Oya Seiro , Katabami Kenichi , Kodama Takamitsu , Sera Makoto , Takei Hirokazu , Taniguchi Hayato , Nakao Shunichiro , Funakoshi Hiraku , Yamaga Satoshi , Senoo Satomi , Kimura Akio 
Published: June 2024

AbstractOwing to the miniaturization of diagnostic ultrasound scanners and their spread of their bedside use, ultrasonography has been actively utilized in emergency situations. Ultrasonography performed by medical personnel with focused approaches at the bedside for clinical decision‐making and improving the quality of invasive procedures is now called point‐of‐care ultrasonography (POCUS). The concept of POCUS has spread worldwide; however, in Japan, formal clinical guidance concerning POCUS is lacking, except for the application of focused assessment with sonography for trauma (FAST) and ultrasound‐guided central venous cannulation. The Committee for the Promotion of POCUS in the Japanese Association for Acute Medicine (JAAM) has often discussed improving the quality of acute care using POCUS, and the “Clinical Guidance for Emergency and Point‐of‐Care Ultrasonography” was finally established with the endorsement of JAAM. The background, targets for acute care physicians, rationale based on published articles, and integrated application were mentioned in this guidance. The core points include the fundamental principles of ultrasound, airway, chest, cardiac, abdominal, and deep venous ultrasound, ultrasound‐guided procedures, and the usage of ultrasound based on symptoms. Additional points, which are currently being considered as potential core points in the future, have also been widely mentioned. This guidance describes the overview and future direction of ultrasonography for acute care physicians and can be utilized for emergency ultrasound education. We hope this guidance will contribute to the effective use of ultrasonography in acute care settings in Japan.
Common Biosynthesis of Non‐Canonical C16 Terpenes through a Fragmentation‐Recombination Mechanism
Authors: Xu Houchao , Goldfuss Bernd , Dickschat Jeroen S. 
Published: June 2024

AbstractThe biosynthesis of six recently reported non‐canonical C16 sesquiterpenoids named after ancient Greek philosophers, archimedene, aristotelene, eratosthenene, pythagorene, α‐democritene and anaximandrene, was investigated through density functional theory (DFT) calculations and isotopic labeling experiments. The results revealed for all compounds except archimedene a unique fragmentation‐recombination mechanism as previously demonstrated for sodorifen biosynthesis, in addition to a remarkable “dancing” mechanism for anaximandrene biosynthesis.
Mesencephalic trigeminal neuron dendritic structures in the macaque
Authors: Wang Niping , Warren Susan , May Paul J. 
Published: June 2024

AbstractIt is presumed that the unusual central location of mesencephalic trigeminal neurons is a specialization that allows them to receive synaptic input. However, relatively few synaptic terminals were observed on the somata of mesencephalic trigeminal neurons in macaque monkeys via electron microscopy. This leaves the question of dendritic synaptic terminals open. Unlike the pseudounipolar neurons found in the trigeminal ganglion, some mesencephalic trigeminal neurons have been reported to be multipolar cells exhibiting a number of dendritic processes in non‐primate species. To examine whether this morphological feature was also present in macaque monkeys, we retrogradely filled these cells with biotinylated dextran amine by injecting it into the trigeminal nerve entry zone. A portion of the mesencephalic trigeminal neurons exhibited short, poorly branched, dendritic processes. They also exhibited very fine, short processes believed to be somatic spines. Thus, primate trigeminal mesencephalic neurons appear to have specializations aimed at increasing the membrane surface area available for synaptic input.
Synthesis of ω‐Hydroxy Fatty Acid Alkyl Esters by Macrocyclic Lactones Alcoholysis Catalyzed by Homoleptic and Heteroleptic Zinc Aryloxides
Authors: Petrus Rafał , Matuszak Karolina , Kinzhybalo Vasyl 
Published: June 2024

AbstractA series of zinc aryloxides, [Zn4(sal‐Me)8]⋅2.5(C7H8) (1), [Zn4(sal‐Me)8]⋅CH2Cl2 (2), [Zn4(μ3‐OR)2(sal‐R)6] (3) (for R=Me (0.51), Et (0.49)), [Zn4(μ3‐OMe)4(sal‐Me)4(HOMe)4] (4), [Zn(sal‐Me)2(py)2]⋅THF (5), {[Zn(sal‐Me)2(tmbpy)] ⋅ 2(C6H5CH3)}n (6), [Zn2(sal‐Me)2(THF)2Cl2] ⋅ 0.5(C6H5CH3) (7), and [Zn4(μ3‐OMe)2(sal‐Me)4Cl2] (8) (Hsal‐Me=methyl salicylate, py=pyridine, tmbpy=4,4′‐trimethylenedipyridine) were obtained that have different nuclearities and central core topologies and contain ligands of different basicity and coordination abilities.
Do not walk into darkness in greenhushing: A cross‐cultural study on why Chinese and South Korean corporations engage in greenhushing behavior
Authors: Tao Zhibin 
Published: June 2024

AbstractThis study focuses on exploring the factors influencing why companies engage in greenhushing decisions in the cultural backgrounds of China and Republic of Korea. Structural equation modeling analysis indicates that in these two countries, reputational risk not only directly leads to corporate greenhushing behavior, but also exerts its influence through conservatism as a mediating factor. Reputational risk causes companies to exhibit conservatism, which in turn leads to the adoption of greenhushing behavior. Furthermore, tests for moderation effects revealed that, in the Chinese sample data, a transparent information disclosure mechanism has the ability to mitigate the impact of reputational risk on corporate greenhushing behavior, as well as to alleviate the influence of conservatism on corporate greenhushing behavior. In the South Korean sample data, a transparent information disclosure mechanism can moderate the impact of reputational risk on conservatism and corporate greenhushing behavior. Finally, the fsQCA method is tested to derive the different configurations and pathways that lead to the strong emergence of greenhushing behavior in companies in China and Republic of Korea, as well as to identify the most influential pathways. This study provides substantial theoretical support for further exploration of the causal mechanisms of corporate greenhushing behavior and promotion of cross‐cultural comparisons and learning in the international environmental management field. In addition, provides rich empirical support and theoretical guidance for corporate environmental management decision‐making and policy formulation. The findings highlight the further standardization and strengthening of transparent information disclosure mechanisms will be an important direction for future environmental policy development.
Impact of rural location on receipt of standard of care treatment and survival for locally advanced bladder cancer in Louisiana
Authors: Escott Megan , Yi Yong , Foret Ashley , Li TingTing , Hsieh Mei‐Chin , Delacroix Scott E. , Wu Xiao‐Cheng , Westerman Mary E. 
Published: June 2024

AbstractObjectiveWe aim to determine the effect of region of residence (urban vs. rural) on the odds of receiving standard of care treatment for locally advanced BCa in Louisiana and its impact on survival outcomes.MethodsUsing the Louisiana Tumor Registry, we identified American Joint Committee on Cancer (AJCC) stage II or III, BCa diagnoses in Louisiana residents between 2010 and 2020. Treatment received was classified as standard or non‐standard of care according to American Urological Association (AUA) guidelines and location of residence was determined using Rural Urban Commuting Area‐Tract‐level 2010 (RUCA). Multivariable logistic regression analyses and multivariate cox proportional hazard analyses were performed.ResultsOf 983 eligible patients, 85.6% (841/983) lived in urban areas. Overall, only 37.5% received standard‐of‐care (SOC) for the definitive management of locally advanced bladder cancer. Individuals living in rural areas (OR 0.53, 95% CI: 0.31–0.91, p = 0.02) were less likely to receive standard of care treatment. Both rural residence and receipt of non‐standard of care therapy were associated with an increased risk of bladder cancer‐specific (adj HR 1.53, 95% CI: 1.09–2.14, p = 0.01 and adj HR: 1.85, 95% CI: 1.43–2.39, <0.0001) and overall mortality (adj HR: 1.28, 95% CI: 1.01–1.61, p = 0.04 and adj HR: 1.73 95% CI: 1.44–2.07, p < 0.0001).ConclusionsMost patients with locally advanced bladder cancer in Louisiana do not receive SOC therapy. Individuals living in rural locations are more likely to receive non‐standard of care therapy than individuals in urban areas. Nonstandard of care treatment and rural residence are both associated with worse survival outcomes for Louisiana residents with locally advanced bladder cancer.