bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of inflammatory periodontal diseases
Authors: Onerova Aiman , Yeslyamgaliyeva Ardak 
Published: July 2024

BackgroundDetermining the prevalence of inflammatory periodontal diseases makes it possible to determine the age group most prone to them, which will help to implement correct treatment and prevention measures for persons of this group, aimed at increasing the level of individual and public health of the Republic of Kazakhstan. The purpose of the study was to determine the prevalence of inflammatory periodontal diseases among the population of the city of Astana according to several criteria and to compare data on the statistics of periodontitis incidence from the world and Kazakhstan.ObjectiveThe research was conducted using the methods of clinical examinations and statistical data processing.Material and methodsThe study involved 642 people aged 18 to 80 years who, within twelve months, applied to dental institutions in the city of Astana and were checked according to the inclusion and exclusion criteria. Clinical studies included determining the level of oral hygiene using the OHI-S simplified oral hygiene index and determining the condition of periodontal tissue using the CPITN periodontal disease treatment need index.ResultsIt was found that the highest prevalence of various forms of gingivitis and periodontitis was observed in the 66-80 age group – 99% and 69%, respectively. The general distribution in all groups indicated a directly proportional relationship between the frequency of detection of inflammatory periodontal diseases and the age of the group participants. A comparison of data on the incidence of periodontal disease in the world and in Kazakhstan showed a 3.52% lower incidence rate in Kazakhstan compared to the world average.ConclusionsThe use of regular and timely preventive and treatment measures for the population group most prone to inflammatory periodontal diseases will make it possible to improve the state of individual health of the population and, accordingly, raise the level of public health.
Persepsi Masyarakat Terhadap Kinerja Unit Pelayanan Administrasi Terpadu di Kecamatan Parung Kabupaten Bogor
Authors: Rahmat Subur  , Kasmad  , Dedik Supardiono  
Published: July 2024

ABSTRAK

Penelitian ini berjudul “Persepsi Masyarakat Terhadap Kinerja Pegawai Di Unit Pelayanan Administrasi Terpadu Kecamatan (PATEN) Pada Kantor Kecamatan Parung Kabupaten Bogor”. Tujuan dari penelitian ini untuk mengetahui kinerja pegawai di unit pelayanan administrasi terpadu kecamatan (PATEN) dan faktor-faktor yang menghambat kinerja pegawai di unit pelayanan administrasi terpadu kecamatan (PATEN) pada Kantor Kecamatan Parung Kabupaten Bogor. Penelitian ini menggunakan metode penelitian deskriptif kualitatif, dan teknik pengambilan data yag digunakan adalah observasi, wawancara, dan Forum Group Discussion (FGD). Teknik analisa data menggunakan reduksi data, penyajian data, dan menarik kesimpulan. Informan utama dalam penelitian ini yaitu masyarakat Kecamatan Parung Kabupaten Bogor sebanyak 25 orang informan serta 4 orang Pegawai Kantor Parung Kabupaten Bogor sebagai anggota FGD yang terdiri dari pimpinan dan sub jabatan terkait pelayanan dan kepegawaian. Hasil dan pembahasan penelitianini menunjukan Kinerja Pegawai Di Unit Pelayanan Administrasi Terpadu Kecamatan (PATEN) Kantor Kecamatan Parung Kabupaten Bogor kepada masyarakat kurang optimal dimana masih terjadi keterlambatan waktu dalam pembuatan dokumen kependudukan, kejelasan persyaratan, sikap dan perilaku pegawaiyang kurang ramah dalam memberikan pelayanan kepada masyarakat. Namun dari hal tersebut sistem pelayanan sudah inovatif dengan penerapan pelayanan online via aplikasi dengan tujuan mempermudah masyarakat dan sikap tanggung jawab pegawai yang tinggi. Faktor-faktor yang menghambat kinerja pegawai Kantor Kecamatan Parung Kabupaten Bogor dari hasil wawancara dan FGD serta observasi langung peneliti yang menjadi penghambat adalah kurangnya Informasi yang diketahui masyarakat, tidak lengkapnya data pemohon, tumpang tindih data administrasi.
Kata-kata Kunci: Kinerja Pegawai, Inovasi, dan Pelayanan Administrasi Terpadu
Peranan Koperasi Dalam Mendukung Permodalan Usaha Mikro, Kecil dan Menengah (Studi Kasus pada Koperasi Serba Usaha Mestika)
Authors: Ripho Delzy Perkasa  , Aprilia Rahmatunisa Purba  , Dila Alvina  , Syahrul Aman  
Published: July 2024

ABSTRAK

Penelitian ini bertujuan untuk mengkaji peran Koperasi Simpan Pinjam (KSP) dalam mendukung pengembangan Usaha Mikro, Kecil, dan Menengah (UMKM) di Indonesia. Studi ini mencakup evaluasi faktor-faktor penunjang dan penghambat yang memengaruhi efektivitas KSP dalam mendukung pertumbuhan UMKM, serta mengidentifikasi perbedaan dengan penelitian terdahulu. Metode penelitian yang digunakan adalah studi kualitatif dengan pendekatan deskriptif-analitis. Data dikumpulkan melalui wawancara dengan pengelola KSP, anggota UMKM, dan pemangku kepentingan terkait. Data tersebut kemudian dianalisis secara tematik untuk mengidentifikasi pola-pola dan temuan utama. Hasil penelitian menunjukkan bahwa peran KSP dalam mendukung pengembangan UMKM sangat signifikan, terutama dalam hal pemberian akses modal, pelatihan manajerial, dan dukungan ekonomi lokal. Namun, terdapat beberapa faktor penghambat seperti keterbatasan sumber daya manusia dan regulasi yang kompleks yang dapat mengurangi efektivitas KSP. Penelitian ini menekankan pentingnya peran KSP dalam mendukung pertumbuhan UMKM dan menyarankan adanya upaya untuk memperkuat kapasitas internal KSP, menyederhanakan regulasi, dan meningkatkan kerjasama antara koperasi, pemerintah, dan sektor swasta untuk menciptakan lingkungan yang lebih kondusif bagi pengembangan UMKM di Indonesia.

Kata Kunci: Koperasi Simpan Pinjam, UMKM, Kota Medan
La Multidimensional Financial Literacy Scale: proposta di un nuovo strumento per la misurazione della financial literacy
Authors: Turco Elena , Robba Matteo , Iannello Paola 
Published: July 2024

L'alfabetizzazione finanziaria (financial literacy) è l'insieme delle conoscenze e competenze relative alla gestione delle proprie risorse finanziarie.Possedere tali nozioni e abilità consente di prendere decisioni finanziarie che impattano positivamente sul proprio benessere personale. Ad oggi gli strumenti per misurare il livello di alfabetizzazione finanziaria dell'individuo sono molteplici a causa dell'esistenza di diverse concettualizzazioni del costrutto stesso. A partire dalla definizione dell'Organization for Economic Co-operation and Development (OECD), che considera l'alfabetizzazione finanziaria come l'insieme di consapevolezza, conoscenze, competenze, atteggiamenti e comportamenti in tale ambito, il presente contributo intende descrivere la progettazione di un nuovo strumento di misura della financial literacy. La Multidimensional Financial Literacy Scale (MFLS) vuole proporsi come nuovo strumento di misurazione dell'alfabetizzazione finanziaria intesa come costrutto multidimensionale. Gli item della nuova scala costituiscono l'operazionalizzazione dei costrutti teorici inclusi nella definizione dell'Organization for Economic Cooperation and Development (OECD). La scala presenta una struttura modulare, in cui gli item sono ordinati per gradiente di difficoltà, da livello base a livello avanzato. Il presente contributo, oltre alla presentazione di un nuovo strumento di misurazione della financial literacy, offre altresì una riflessione teorica sulle motivazioni scientifiche che hanno portato alla creazione della nuova scala che, tuttavia, necessita di studi futuri che ne testino le proprietà psicometriche.
Investigating the Preference on Public Transport in a Metropolitan Area of Lampung Province, Indonesia
Authors: Purba Aleksander , Akbari Rahmatulloh , Widyawati Ratna , Usman Kristianto , Purba John Tampil 
Published: July 2024

Metropolitan areas grow and develop as the region's population grows and travels to meet needs such as education, work, family matters, and business. Kotabumi and Bandar Lampung are two of the regions that have grown faster in recent years as a result of the construction of the trans-Sumatera toll road, while railway has been operating for more than two decades. The main objective of this works is to explore preference towards public transport with service quality attributes. The minibus mode or "travel" in Indonesia is defined as transportation services that pick up passengers. This study surveyed 384 commuters who used three modes of transportation: rail, bus, and minibus with relatively different service characteristics and trip purposes of school/college (35%), leisure (28%), family affairs (19%), work (14%), and business (4%) and represented predominantly an age range of 17 to 55 years (97%). The rail mode's utility value was 4.383, while the bus and minibus modes' utility values were 3.751 and 3.737, respectively. Because utility value reflects the level of user satisfaction with the overall attributes and service quality, the rail mode has a much higher probability of being chosen by respondents, with a probability level of 48.65%, compared to the bus and minibus modes, which have a probability level of 25.86% and 25.49%, respectively.
Finite element simulations of smart fracture plates capable of cyclic shortening and lengthening: which stroke for which fracture?
Authors: Roland Michael , Diebels Stefan , Wickert Kerstin , Pohlemann Tim , Ganse Bergita 
Published: July 2024

Introduction: Bone healing can be improved by axial micromovement, as has been shown in animals and human patients with external fixators. In the development of smart fracture plates, the ideal amount of stroke for different fracture types in the different healing stages is currently unknown. It was hypothesized that the resulting strain in the fracture gap of a simple tibial shaft fracture does not vary with the amount of axial stroke in the plate, the fracture gap size, and the fracture angle.Methods: With finite element simulations based on body donation computed tomography data, the second invariant of the deviatoric strain tensor (J2), strain energy density, hydrostatic strain, octahedral shear strain, and percentage of the fracture gap in the “perfect healing window” were computed for different gap sizes (1–3 mm), angles (5°–60°), and plate stroke levels (0.05–0.60 mm) in three healing stages. Multiple linear regression analyses were performed.Results: Findings showed that an active fracture plate should deliver an axial stroke in the range of 0.10–0.45 mm. Different optimal stroke values were found for each healing phase, namely, 0.10–0.25 mm for the first, 0.10 mm for the second, and 0.35–0.45 mm for the third healing phase, depending on the fracture gap size and less on the fracture angle. J2, hydrostatic strain, octahedral shear strain and the strain energy density correlated with the fracture gap size and angle (all p &lt; 0.001). The influence of the fracture gap size and angle on the variability (adjusted R2) in several outcome measures in the fracture gap was shown to vary throughout healing. The contribution to the variability of the percentage of the fracture gap in the perfect healing window was greatest during the second healing phase. For J2, strain energy density, hydrostatic strain, and octahedral shear strain, the fracture gap size showed the greatest contribution in the third fracture healing phase, while the influence of fracture angle was independent of the healing phase.Discussion: The present findings are relevant for implant development and to design clinical studies that aim to accelerate fracture healing using axial micromovement.
Evolution characteristics and mechanisms of the spring warm pool in the Bay of Bengal
Authors: Lin Wenshu , Qiu Yun , Ni Xutao , Lin Xinyu , Liu Tongtong 
Published: July 2024

Knowledge of spring warm pool in the Bay of Bengal (BoBWP) is key for further understanding the climate variability in this region and beyond, but little is known about the BoBWP climatological state and the related mechanisms. In this study, we investigate the spatial structure and evolution of the BoBWP using daily Optimum Interpolation SST data from 1982-2022 in combination with multi-source data. Our analysis shows that the BoBWP is located in the central bay (6°-13°N) with a thickness around 20 m ~ 40 m. Composite analysis indicates that the BoBWP emerges in early April, peaks in early May and dissipates in early June. During the developing period, the net heat flux dominates the formation of spring warm pool through significant air-sea coupling processes, and induces the warming rate of 0.27°C/10d in the mixed layer, which is far larger than the contribution of oceanic dynamical processes (0.01°C/10d). During the decaying period, the net heat flux also plays a dominant role, with a cooling rate of -0.21°C/10d, meanwhile ocean dynamical processes contribute to the cooling of the warm pool with a rate of -0.01°C/10d. Additionally, the SST and the area of the BoBWP are significantly correlated with ENSO (r=0.66 and 0.73, p=0.05). During El Niño decaying year, the BoBWP primarily expands in a southward direction, with a 75% increase in area. Conversely, during La Niña decaying year, the BoBWP almost disappears, with a 52% decrease.
A randomized controlled trial comparing tacrolimus versus hydrocortisone for the treatment of atopic dermatitis in children: new perspectives on interferon gamma-induced protein and growth-related oncogene-α
Authors: Binsaleh Ammena Y. , Bahaa Mostafa M. , Elmasry Thanaa A. , Elberri Eman I. , Kotkata Fedaa A. , El-Khateeb Eman , Kamal Marwa , El-samongy Marwa Ahmed , Hamouda Amir O. , Alghamdi Amira M. , Alrubia Sarah , Salahuddin Muhammed M. , Eltantawy Nashwa 
Published: July 2024

IntroductionAtopic dermatitis (AD) is a type of chronic inflammatory disorder that affects children.AimTo investigate whether hydrocortisone or tacrolimus could be more effective for treating AD in children.Patients and methodsThis clinical randomized investigation included 100 children with AD who met the eligibility criteria. AD patients were recruited from Tanta University’s Dermatology Department and divided into two groups (n = 50)., For four months, group 1 (the hydrocortisone group) received topical hydrocortisone cream. Group 2 received topical tacrolimus for four months. A dermatologist evaluated the patients at the start and four months after the treatment had been initiated to measure serum concentrations of neutrophil chemoattractant growth-related oncogene-α (GRO-α), interferon gamma induced protein 10 (IP-10), tumor necrosis factor alpha (TNF-α), vascular adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1). All patients were examined using the modified Eczema Area and Severity Index (mEASI) score.ResultsTacrolimus group showed a significant reduction in serum levels of all measured biomarkers (p &lt; 0.05) when compared to its baseline and when compared to the hydrocortisone group. Both groups displayed a significant decline in mEASI score in comparison with their baseline values (p &lt; 0.05).ConclusionIn children with AD, tacrolimus reduces inflammatory biomarkers better than hydrocortisone, suggesting its potential as a more effective treatment option.Clinical trial registrationhttps://clinicaltrials.gov, identifier NCT05607901.
Case report: Genetic diagnoses in a pediatric patient with retinoblastoma and comorbid global developmental delay: three distinct entities diagnosed by whole exome sequencing in a single patient
Authors: Chen Jing , Yang Shuo , Wang He , Wang Hongjing , Xiao Yuanyuan , Liu Shanling 
Published: July 2024

BackgroundThe objective of this study was to explore the genetic etiology and propose a genetic diagnosis and counseling strategy for children with retinoblastoma (RB) and global developmental delay (GDD).Case presentationWe report on a 2 years and 4 months old boy with binocular retinoblastoma and global developmental delay (included intellectual disability, language development delay, motor development delay, etc.). Genomic DNA was extracted from peripheral blood mononuclear cells isolated from the proband and his parents. Whole exome sequencing (WES) was carried out for the proband and his parents to identify genetic etiology, which was subsequently verified by quantitative polymerase chain reaction (qPCR).The WES revealed a gross heterozygous deletion in the RB transcriptional corepressor 1 (RB1, OMIM:614041) gene, including exon 7–8, in the affected proband but not in his parents. Additionally, two pathogenic copy number variations (CNVs) were identified: a duplication at 7q11.23 and a microdeletion at 16p11.2-p12.2, respectively. Furthermore, the genomic qPCR analysis demonstrated a 50% reduction in the copy numbers of exon 7 and exon 8 in the RB1 gene of the proband, as compared to those detected in his parents. Simultaneous variants in the RB1 gene and two pathogenic CNVs can precisely explain the genetic etiology of the proband.ConclusionThe present study firstly reports a novel gross deletion variant of the RB1 gene coexisting with two pathogenic CNVs in a pediatric patient with retinoblastoma and comorbid global developmental delay in China. Additionally, our findings strongly support the use of WES in pediatric patients with RB comorbid GDD, and WES is recommended as the first-tier test.
Retinal debris triggers cytotoxic damage in cocultivated primary porcine RPE cells
Authors: Wagner Natalie , Tsai Teresa , Reinehr Sabrina , Theile Janine , Dick H. Burkhard , Joachim Stephanie C. 
Published: July 2024

IntroductionOne of the most common causes of vision loss in the elderly population worldwide is age-related macular degeneration (AMD). Subsequently, the number of people affected by AMD is estimated to reach approximately 288 million by the year 2040. The aim of this study was to develop an ex vivo model that simulates various aspects of the complex AMD pathogenesis.MethodsFor this purpose, primary porcine retinal pigment epithelial cells (ppRPE) were isolated and cultured. One group was exposed to medium containing sodium iodate (NaIO3) to induce degeneration. The others were exposed to different supplemented media, such as bovine serum albumin (BSA), homogenized porcine retinas (HPR), or rod outer segments (ROOS) for eight days to promote retinal deposits. Then, these ppRPE cells were cocultured with porcine neuroretina explants for another eight days. To assess the viability of ppRPE cells, live/dead assay was performed at the end of the study. The positive RPE65 and ZO1 area was evaluated by immunocytochemistry and the expression of RLBP1, RPE65, and TJP1 was analyzed by RT-qPCR. Additionally, drusen (APOE), inflammation (ITGAM, IL6, IL8, NLRP3, TNF), oxidative stress (NFE2L2, SOD1, SOD2), and hypoxia (HIF1A) markers were investigated. The concentration of the inflammatory cytokines IL-6 and IL-8 was determined in medium supernatants from day 16 and 24 via ELISA.ResultsLive/dead assay suggests that especially exposure to NaIO3 and HPR induced damage to ppRPE cells, leading in a significant ppRPE cell loss. All supplemented media resulted in decreased RPE-characteristic markers (RPE65; ZO-1) and gene expression like RLBP1 and RPE65 in the cultured ppRPE cells. Besides, some inflammatory, oxidative as well as hypoxic stress markers were altered in ppRPE cells cultivated with NaIO3. The application of HPR induced an enhanced APOE expression. Pre-exposure of the ppRPE cells led to a diminished number of cones in all supplemented media groups compared to controls.DiscussionOverall, this novel coculture model represents an interesting initial approach to incorporating deposits into coculture to mimic AMD pathogenesis. Nevertheless, the effects of the media used need to be investigated in further studies.
Relationship between nausea and vomiting and physical activity in patients with lung cancer undergoing first chemotherapy
Authors: Bai Liandi , Ni Li , Lu JianHong , Zhang Yue Yu , Yin Yuanyuan , Zhang WeiYing , Duan Xia 
Published: July 2024

ObjectiveNausea and vomiting are the distressing and debilitating side effects of chemotherapy. This study explores the relationship between the degree of nausea and vomiting and physical activity in patients with lung cancer during the first chemotherapy cycle.DesignA total of 107 patients with lung cancer who received platinum drugs during chemotherapy in a hospital in Shanghai, China, in 2023 were involved in this study. Data were collected with medical record system and self-reported questionnaires.Questionnaires included the International Physical Activity Questionnaire (IPAQ) and Index of Nausea, Vomiting, and Retching (INVR). IPAQ was used before chemotherapy; INVR was used on the second and sixth day of chemotherapy, followed by the analysis of the correlation between physical activity status and degree of nausea and vomiting during chemotherapy. The influencing factors of nausea and vomiting during chemotherapy in patients with lung cancer were analyzed using logistic regression analysis.ResultsMore than half of the patients experienced nausea, vomiting or retching related symptoms after chemotherapy, and the proportion of moderate to high physical activity was 50.5%. Univariate analysis showed that the degree of nausea and vomiting was influenced by factors such as age, gender, and history of drinking (P &lt; 0.05). The degree of nausea and vomiting was negatively correlated with physical activity (P &lt; 0.05). The multivariate linear analysis showed that gender, history of drinking, and moderate and high physical activity are contributing factors to nausea and vomiting during chemotherapy (P &lt; 0.05).ConclusionModerate and high physical activity before chemotherapy is a protective factor for nausea and vomiting in patients with lung cancer. Physical activity can not only improve the degree of nausea and vomiting in patients with lung cancer but also reduce the incidence in these patients during the first chemotherapy cycle.