bluuebunny/crossref_metadata_2025_split huggingface dataset:
Field study of the comparative efficacy of gamithromycin and tulathromycin for the control of undifferentiated bovine respiratory disease complex in beef feedlot calves at high risk of developing respiratory tract disease
Authors: Torres Siddartha , Thomson Dan U. , Bello Nora M. , Nosky Bruce J. , Reinhardt Chris D. 
Published: May 2013

Abstract
Objective—To compare the efficacy of gamithromycin with that of tulathromycin for control of undifferentiated bovine respiratory disease complex (BRDC) in feedlot calves.
Animals—2,529 weaned crossbred beef calves.
Procedures—At each of 2 feedlots, calves at risk of developing BRDC were administered a single dose of gamithromycin (6.0 mg/kg, SC; n = 1,263) or tulathromycin (2.5 mg/kg, SC; 1,266) metaphylactically. Health (BRDC morbidity, mortality, case-fatality, and retreatment rates) and performance (average daily gain, dry matter intake, and feed-to-gain ratio) outcomes were compared between treatments via classical hypothesis testing. Bioequivalence limits for gamithromycin and tulathromycin were established for outcomes for which no significant difference between treatments was detected.
Results—Mean BRDC morbidity rate (31.0%) for calves administered gamithromycin was greater than that (22.9%) for calves administered tulathromycin; otherwise, health and performance did not differ between treatments. Limits for mean differences within which gamithromycin was considered bioequivalent to tulathromycin were ± 10% for BRDC retreatment rate, ± 3.5% for BRDC mortality rate, ± 16% for case-fatality rate, ± 37 kg for final body weight, ± 0.1 kg/d for average daily gain, ± 0.3 kg/d for dry matter intake, and ± 0.7 for feed-to-gain ratio.
Conclusions and Clinical Relevance—The efficacy of gamithromycin did not differ from that of tulathromycin for all outcomes except morbidity rate; calves administered gamithromycin had a higher BRDC morbidity rate than did calves administered tulathromycin. On the basis of the bioequivalence limits established for this dataset, gamithromycin was considered equivalent to tulathromycin for the control of BRDC.
Field study of the comparative efficacy of gamithromycin and tulathromycin for the treatment of undifferentiated bovine respiratory disease complex in beef feedlot calves
Authors: Torres Siddartha , Thomson Dan U. , Bello Nora M. , Nosky Bruce J. , Reinhardt Chris D. 
Published: May 2013

Abstract
Objective—To compare the efficacy of gamithromycin with that of tulathromycin for the treatment of undifferentiated bovine respiratory disease complex (BRDC) in feedlot calves.
Animals—1,049 weaned crossbred beef calves.
Procedures—At each of 6 feedlots, newly arrived calves with BRDC were administered a single dose of gamithromycin (6.0 mg/kg, SC; n = 523) or tulathromycin (2.5 mg/kg, SC; 526). Case-fatality and BRDC retreatment rates during the first 120 days after treatment, final body weight, and average daily gain (ADG), were compared between treatments. At 2 feedlots, calves were assigned clinical scores for 10 days after treatment to determine recovery rates for each treatment. Bioequivalence limits for gamithromycin and tulathromycin were calculated for outcomes for which there was no significant difference between treatments.
Results—Mean BRDC retreatment rate (17.7%) for calves administered gamithromycin was greater than that (9.0%) for calves administered tulathromycin. Mean case-fatality rate, final body weight, ADG, and clinical score 10 days after treatment did not differ significantly between treatments. Limits for mean differences within which gamithromycin was bioequivalent to tulathromycin were ± 2.4% for case-fatality rate, ± 13 kg for final body weight, and ± 0.1 kg/d for ADG.
Conclusions and Clinical Relevance—Calves administered gamithromycin had a higher BRDC retreatment rate than did calves administered tulathromycin; otherwise, the clinical efficacy did not differ between the 2 treatments for the treatment of BRDC in feedlot calves.
Evaluation of osteochondral sample collection guided by computed tomography and magnetic resonance imaging for early detection of osteoarthritis in centrodistal joints of young Icelandic horses
Authors: Ley Charles J. , Ekman Stina , Dahlberg Leif E. , Björnsdóttir Sigríður , Hansson Kerstin 
Published: May 2013

Abstract
Objective—To evaluate the use of CT and MRI for guidance of osteochondral sample collection for histologic detection of early osteoarthritic lesions in centrodistal (distal intertarsal) joints of horses.
Sample —Right tarsal joints from the cadavers of 24 Icelandic horses aged 29 to 31 months.
Procedures—CT and MRI were used to evaluate the extent of suspected osteoarthritic changes in centrodistal joints, which were graded with a semiquantitative system. The anatomic regions with the highest grade of change were identified, and osteochondral samples were obtained from these regions. Samples were also obtained from the same centrodistal joints at predetermined sites. Histologic examination of all samples was performed, with samples classified as negative or positive for osteoarthritis, and results were compared between sample collection methods.
Results—Histologic examination revealed osteoarthritic lesions in 29% (7/24) of centrodistal joints with the predetermined method and in 63% (15/24) with the image-guided method. Significant associations were identified between histologic osteoarthritis detection and the summed image-guided sample collection site image grades, central osteophytes, articular cartilage thickness abnormalities, grade 2 articular mineralization front defects, and grade 2 marginal osteophytes.
Conclusions and Clinical Relevance—CT and MRI aided the detection of focal changes suggestive of early-stage osteoarthritis in the centrodistal joints of equine cadavers and may be useful for detection of similar disease in live horses. The first morphological changes of centrodistal joint osteoarthritis were suspected to be in the articular cartilage and the articular mineralization front regions.
Measurement repeatability of tibial tuberosity-trochlear groove offset distance in red fox (Vulpes vulpes) cadavers
Authors: Miles James E. , Jensen Bente R. , Kirpensteijn Jolle , Svalastoga Eiliv L. , Eriksen Thomas 
Published: May 2013

Abstract
Objective—To describe CT image reconstruction criteria for measurement of the tibial tuberosity-trochlear groove (TT-TG) offset distance, evaluate intra- and inter-reconstruction repeatability, and identify key sources of error in the measurement technique, as determined in vulpine hind limbs.
Animals—12 red fox (Vulpes vulpes) cadavers.
Procedures—CT images of each hind limb in intact cadavers were obtained; at 1-week intervals, 3 reconstructions were performed that were based on 1 plane passing through the centers of the femoral head and medial condyle and parallel to the caudal femoral condyles, 1 plane aligned with the femoral trochlea, and a third orthogonal plane. Randomized and anonymized reconstructions were assessed for TT-TG offset distance with a single-image technique by 1 observer, and inter-reconstruction repeatability and intra- and inter-reconstruction measurement repeatability were assessed via the repeatability coefficient and intraclass correlation coefficient.
Results—Multiplanar reconstructions of hind limb images were repeatedly made to within a few degrees of each other. Intra- and inter-reconstruction repeatability for TT-TG offset distance measurement was good. Repeatability was most affected by accurate identification of the tibial tuberosity and femoral trochlea landmarks.
Conclusions and Clinical Relevance—Results obtained from vulpine hind limb CT images indicated that reconstructions can be made with a high degree of repeatability when based on strictly defined and applied criteria. The TT-TG offset distance has potential as an objective assessment of alignment of the distal portion of the quadriceps mechanism; its use as an aid in case selection for corrective femoral osteotomy among dogs with medial patellar luxation warrants investigation.
Systemic immune responses in Cytauxzoon felis-infected domestic cats
Authors: Frontera-Acevedo Karelma , Balsone Nicole M. , Dugan Melissa A. , Makemson Cheryl R. , Sellers Llewelyn B. , Brown Holly M. , Peterson David S. , Creevy Kate E. , Garner Bridget C. , Sakamoto Kaori 
Published: May 2013

Abstract
Objective—To characterize systemic immune responses in Cytauxzoon felis-infected cats.
Sample—Blood and lung samples obtained from 27 cats.
Procedures—Cats were allocated into 4 groups: cats that died of cytauxzoonosis, acutely ill C felis-infected cats, healthy survivors of C felis infection, and healthy uninfected cats. Serum concentrations of tumor necrosis factor-α and interleukin-1 β were measured and serum proteins characterized. Blood smears were stained immunocytochemically and used to assess immunoglobulin deposition. Immunohistochemical expression of CD18 and tumor necrosis factor-α were compared in lung tissues obtained from cats that died and healthy uninfected cats. A real-time reverse-transcription PCR assay for CD18 expression was performed on selected blood samples from all groups.
Results—Concentrations of both cytokines were greater and serum albumin concentrations were significantly lower in cats that died of cytauxzoonosis, compared with results for all other groups. Erythrocytes from acutely ill cats and survivors of C felis infection had staining for plasmalemmal IgM, whereas erythrocytes from the other groups did not. Increased staining of C felis-infected monocytes and interstitial neutrophils for CD18 was detected. The real-time reverse-transcription PCR assay confirmed a relative increase in CD18 expression in cats that died of cytauxzoonosis and acutely ill cats, compared with expression in other groups. Immunostaining for TNF-α in lung samples confirmed a local proinflammatory response.
Conclusions and Clinical Relevance—Results indicated immunopathologic responses were greater in cats that died of C felis infection than in cats that survived C felis infection.
Acute and chronic effects of tepoxalin on kidney function in dogs with chronic kidney disease and osteoarthritis
Authors: Lomas Amy L. , Lyon Shane D. , Sanderson Michael W. , Grauer Gregory F. 
Published: May 2013

Abstract
Objective—To determine whether tepoxalin alters kidney function in dogs with chronic kidney disease (CKD).
Animals—16 dogs with CKD (International Renal Interest Society stage 2 or 3) and osteoarthritis.
Procedures—Kidney function was assessed via serum biochemical analysis, urinalysis, urine protein-to-creatinine concentration ratio, urine γ-glutamyl transpeptidase-to-creatinine concentration ratio, iohexol plasma clearance, and indirect blood pressure measurement twice before treatment. Dogs received tepoxalin (10 mg/kg, PO, q 24 h) for 28 days (acute phase; n = 16) and an additional 6 months (chronic phase; 10). Recheck examinations were performed weekly (acute phase) and at 1, 3, and 6 months (chronic phase). Kidney function variables were analyzed via repeated-measures ANOVA.
Results—There was no difference over time for any variables in dogs completing both phases of the study. Adverse drug events (ADEs) resulting in discontinuation of tepoxalin administration included increased serum creatinine concentration (1 dog; week 1), collapse (1 dog; week 1), increased liver enzyme activities (1 dog; week 4), vomiting and diarrhea (1 dog; week 8), hematochezia (1 dog; week 24), and gastrointestinal ulceration or perforation (1 dog; week 26). Preexisting medical conditions and concomitant drug use may have contributed to ADEs. Kidney function was not affected in the latter 5 dogs. Discontinuation of tepoxalin administration stabilized kidney function in the former dog and resolved the ADEs in 4 of the 5 latter dogs.
Conclusions and Clinical Relevance—Tepoxalin may be used, with appropriate monitoring, in dogs with International Renal Interest Society stage 2 or 3 CKD and osteoarthritis.
Impact de l'implantation des dispensaires et de l'activité des « passants » et des vendeurs de médicaments chinois sur la maladie djékwasô en pays Gouro (Côte d'Ivoire)
Authors: Haxaire Claudie 
Published: May 2013

À l’époque où les dispensaires de soins de santé rurale dotés de médicaments génériques s’implantaient dans la région de Zuénoula (RCI), le système de soins de santé se voyait doté de nouveaux acteurs, à savoir les vendeurs ambulants de médicaments « chinois », qui concurrençaient les « passants » de circuits alternatifs. Une enquête longitudinale dans trois villages gouro a permis d’analyser l’impact de l’accessibilité de ces médicaments et de leur efficacité perçue sur le redécoupage de l’ensemble djekwasô, entité nosologique populaire qui peut recouvrir le paludisme, diverses fièvres, les hépatites voire le sida. Alors que ces différents circuits de commercialisation distribuaient des médicaments industriels de mêmes formules, qui auraient pu prendre une connotation différente selon les circuits, ce furent au contraire les circuits qui se spécialisèrent en sélectionnant les médicaments selon leur efficacité perçue sur les variantes de l’ensemble djekwasô qu’ils prétendaient traiter.
Dans les ténèbres de l'incestualité
Authors: Payen Françoise 
Published: May 2013

Ce travail rend compte d’une recherche d’un groupe de l’ IPSYC (IPSYC : Institut de psychanalyse de couple) autour de la conflictualité psychique conjugale avec comme question corollaire : comment le groupe formé par le couple et le clinicien peut-il l’appréhender et la traiter ? La conflictualité psychique conjugale, distincte de la conflictualité interne du sujet, n’est pas non plus la résonance entre les deux conflictualités psychiques de chacun des partenaires, mais une production psychique couplale. Elle se manifeste au sein du néogroupe formé par le clinicien et le couple par l’apparition d’imagos menaçantes. L’auteur a fait l’hypothèse que, dans le travail analytique avec un couple, ce néogroupe permet le passage d’un stade de la groupalité à un autre, entraînant la chute des imagos menaçantes.
Mariage pour tous et homoparentalité
Authors: Théry Irène 
Published: May 2013

Pourquoi les homosexuels n’avaient-ils pas, jadis, l’idée de demander à se marier alors que le souci d’égalité entre tous les couples, la revendication à être « comme les autres » est manifeste aujourd’hui ? Il est important de situer les interrogations et changements actuels dans le temps long de l’histoire. L’article montre dans quelle mesure les fondements du mariage et de la filiation se sont modifiés, désormais la filiation ne repose plus sur le socle du mariage. L’évolution des attitudes des homosexuels est en lien direct avec ces transformations.
La reconfiguration de la socialisation précoce
Authors: Neyrand Gérard 
Published: May 2013

Notre époque de profonde transformation des rapports familiaux et éducatifs voit certaines instances de socialisation du jeune enfant prendre une importance croissante : les médias, les modes d’accueil, les pairs. Le parentalisme inhérent au dispositif de parentalité contemporain a tendance à masquer l’importance de cette fonction partagée de coéducation des enfants. Pourtant celle-ci constitue encore plus profondément une cosocialisation, qu’il conviendrait de mieux connaître pour répondre aux objectifs affichés de la démocratie d’autonomisation et d’épanouissement des individus.
Potential Therapies for Food Allergy: A Review
Authors: Kattan Jacob D. , Wang Julie 
Published: May 2013

CME Educational Objectives

1.
Understand the numerous food allergy therapies, both allergen specific and non-specific, currently under investigation.

2.
Discuss the safety concerns that accompany potential food allergy treatments.

3.
Appreciate the difference between desensitization and tolerance as they relate to food allergy.

Food allergy is a widespread problem that has been increasing in prevalence in recent years. Avoidance of food allergens is difficult. Food allergic reactions are common and can be severe. Unfortunately, there is little in the way of therapies for food allergy, and strict allergen avoidance remains the standard of care. Several therapeutic approaches are currently being investigated, including subcutaneous, oral, and sublingual immunotherapy, anti-immunoglobulin E therapy, and traditional Chinese medicine. Although results thus far show promise for several of these strategies, further studies are needed to evaluate the safety, efficacy, and long-term outcomes before any food allergy therapies currently under investigation are ready for widespread use in clinical practice.
The Influence of Corneal Volume in Surgical Planning: Insights for a New Parameter for the Ferrara Ring Nomogram
Authors: Torquetti Leonardo , Dias Wagner Gomes 
Published: May 2013

ABSTRACT

Purpose
To evaluate the corneal volume (CV) before and after Ferrara intrastromal corneal ring segments (ICRS) implantation and its influence in clinical outcomes in keratoconus patients.

Materials and methods
A total of 77 eyes of 42 keratoconus patients consecutively implanted with the Ferrara ICRS were evaluated with a Pentacam (Oculus Optikgerate GmbH). The following parameters were obtained: Anterior corneal asphericity (Q), CV and thinnest corneal thickness (TCT). The inter-relation between Q and CV was evaluated.

Results
In patients with CV inside two standard deviation (SD: 53.51-60.65) of the mean CV, the postoperative asphericity values roughly agreed with expected asphericity values. In patients with CV outside two SD intervals (<53.51 and >60.65) of the mean CV, the postoperative asphericity values did not agreed with expected asphericity values. Corneas with high volumes (>60.65) had less change of asphericity than corneas with low volumes.

Conclusion
The CV is a new parameter, to be better studied, as it seems to be important in ICRS selection. Corneas with high volumes may require more tissue to get flattened and properly reshaped.

How to cite this article
Torquetti L, Ferrara G, Dias WG, Ferrara P. The Influence of Corneal Volume in Surgical Planning: Insights for a New Parameter for the Ferrara Ring Nomogram. Int J Kerat Ect Cor Dis 2013;2(1):12-15.
Deep Anterior Lamellar Keratoplasty for Ectatic Disease
Authors: Ramos Isaac , Schor Paulo , Luz Allan , Babosa Luciene , Fontes Bruno Machado 
Published: May 2013

ABSTRACT
Recently, deep anterior lamellar keratoplasty (DALK) has received attention for patients with ectatic diseases not affecting the endothelium. However, it was not always so. For years, DALK was overlooked due to the difficulty in achieving good visual results, which were considered weak in comparison with the results of penetrating keratoplasty (PK). DALK was proposed to retain a patient's healthy endothelium; thereby avoiding some possible complications of PK. Preservation of the endothelium contributes to prolonged survival of the button and thus overcomes a major cause of failure after PK. DALK is now accepted as a viable alternative to PK. With advances in surgical techniques, instruments, and imaging technologies, visual results obtained with lamellar keratoplasty are equivalent to visual outcomes with PK, in addition to providing a transplant cost benefit owing to a better transplantation survival rate.

How to cite this article
Luz A, Babosa L, Fontes BM, Ramos I, Schor P, Ambrósio R Jr. Deep Anterior Lamellar Keratoplasty for Ectatic Disease. Int J Kerat Ect Cor Dis 2013;2(1):20-27.
History of the Development of the Treatment of Keratoconus
Authors: Barbara Ramez , Abdelaziz Lamis 
Published: May 2013

ABSTRACT
Keratoconus (from Greek meaning horn-shaped cornea) is a degenerative, ectatic disease of the cornea, causing corneal thinning and remodelling into a more conical shape.1 Symptoms include blurring of vision, and a gradual decline in visual acuity.1 It is usually bilateral, but can affect each eye at different severities.1 There are various treatment modalities, both surgical and nonsurgical, both simple and more invasive. Here, we review the history of the development and advances of the wide range of treatment options, since it was first recognized in 1748 up until now.

How to cite this article
Abdelaziz L, Barbara R. History of the Development of the Treatment of Keratoconus. Int J Kerat Ect Cor Dis 2013;2(1):31-33.
Treatment of thrombotic microangiopathy with a focus on new treatment options
Authors: Knöbl P. 
Published: May 2013

SummaryThe thrombotic microangiopathies (TMA) are a heterogeneous group of disorders, characterized by microangiopathic haemolytic anaemia with red cell fragmentation, thrombocytopenia and signs of organ dysfunction due to disturbed microcirculation. Current laboratory methods can be used to better distinguish some of these entities. Organ dysfunction can be severe and life-threatening, and immediate start of sufficient therapy is necessary to avoid permanent damage or death. The therapeutic options, however, are often limited to symptomatic measures, and are not standardized or based on high scientific evidence. During the preceding years, not only considerable progress has been made in better diagnosis of TMA, but also new therapeutic strategies have been established. Initial treatment still is based on plasma exchange and symptomatic measures to protect organ function. New concepts (immunosuppression, targeted anti-von Willebrand factor or anti-complement therapy, replacement with recombinant enzymes) are discussed in this article.
Hereditary thrombotic thrombocytopenic purpura and the hereditary TTP registry
Authors: Taleghani M. Mansouri , von Krogh A.-S. , Fujimura Y. , George J. N. , Hrachovinova I. , Knöbl P. N. , Quist-Paulsen P. , Schneppenheim R. , Lämmle B. , Hovinga J. A. Kremer 
Published: May 2013

SummaryHereditary thrombotic thrombocytopenic purpura (TTP), also known as Upshaw-Schulman syndrome, is a rare recessively inherited disease. Underlying is a severe constitutional deficiency of the von Willebrand factor-cleaving protease, ADAMTS13, due to compound heterozygous or homozygous mutations in the ADAMTS13 gene. The clinical picture is variable and more and more patients with an adult-onset are diagnosed.In the majority of countries the only available treatment is plasma, which when administered regularly can efficiently prevent acute disease bouts. The decision to initiate regular prophylaxis is often not easy, as evidence based guidelines and long term outcome data are lacking. Through the hereditary TTP registry (www.ttpregistry.net, ClinicalTrials.gov identifier: NCT01257269), which was initiated in 2006 and is open to all patients diagnosed with Upshaw-Schulman syndrome and their family members, we aim to gain further information and insights into this rare disease, which eventually will help to improve clinical management of affected patients.
E‐readers, Computer Screens, or Paper: Does Reading Comprehension Change Across Media Platforms?
Authors: Margolin Sara J. , Driscoll Casey , Toland Michael J. , Kegler Jennifer Little 
Published: May 2013

SummaryThe present research examined the impact of technology on reading comprehension. While previous research has examined memory for text, and yielded mixed results of the impact technology has on one's ability to remember what they have read, the reading literature has not yet examined comprehension. In comparing paper, computers, and e‐readers, results from this study indicated that these three different presentation modes do not differentially affect comprehension of narrative or expository text. Additionally, readers were not consistently compensating for difficulties with comprehension by engaging in different reading behaviors when presented with text in different formats. These results suggest that reading can happen effectively in a variety of presentation formats. Copyright © 2013 John Wiley & Sons, Ltd.