bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does combining two evidence-based exercise programs in elderly people with incontinence have a triple effect on incontinence symptoms, balance and functional status?
Authors: SEÇER Melda BAŞER , TOSUN Özge ÇELİKER , AKBAYRAK Türkan , İLÇİN Nursen , TOSUN Gökhan 
Published: July 2024

Abstract

Background: Improving pelvic floor muscle training (PFMT), balance and functional activity is recommended in the treatment of ürinary incontinence(UI) in the elderly. The aim of this study is to examine whether PFMT combined with Otago exercises is effective on symptoms, balance and functional status in elderly people with UI, compared to PFMT alone.
Methods: This study is an assessor‐blinded, randomized controlled trial. Participants with UI aged 65 and over living in a nursig home were randomly assigned to intervention (IG) and control group (CG). The intervention group attended an exercise program that included Otago exercises combined with PFMT. The control group was included in the PFMT program with different positions. Duration of exercise for both groups was 45-60 minutes per session three times a week for 12 weeks. UI symptoms and severity (Pelvic Floor Distress Inventory-20, bladder diary), PFM muscle function (superficial electromyography), balance (Berg Balance Scale), functional status (Senior Fitness Test) and fear of falling (Falls Efficacy Scale) was measured at baseline and after the intervention.
Results: The median age of the IG (n:22) and CG (n:21) was 73.5 and 77, respectively. At baseline and after the intervention within the group, a significant improvement was observed in the PTDE-20 score (IG and CG, p:0.00) and the 2-minute step test in the IG (p:0.02) and CG (p:0.01). A significant decrease was found in the 2.45m get up and go test, PFM work MVC, PFM work average onset, and PFM rest MVC EMG values ​​(p:0.01, p:0.02, p:0.01, p:0.00) in the IG. PFM rest average value was decreased (p:0.04) in the CG.
Conclusion: Considering the fact that functional type (stress and urge type) incontinence is common in the elderly people, both incontinence and functional mobility can be improved more effectively by combining two proven practices in the treatment of incontinence.
miR-144 regulates bovine skeletal muscle satellite cell proliferation and differentiation by targeting the NACC1 gene
Authors: Ding yanling , Zhang Yanfeng , Zhou Xiaonan , Li Chenglong , Su Zonghua , Xu Junjie , Shi Yuangang , li congjun , kang xiaolong 
Published: July 2024

Abstract

miRNAs are encoded by eukaryotic genomes and are characterized by tissue-specific and temporal expression, suggesting that miRNAs play multiple roles in different tissues and developmental periods of a species through a variety of regulatory pathways. miR-144 regulates cell development in other species, but its regulatory mechanism in bovine skeletal muscle satellite cells (BSMSCs) is unknown. So, this experiment was designed to elucidate the function of miR-144 in BSMSCs development. It was found that miR-144 promoted the proliferation of BSMSCs, but it plays an inhibitory role in the differentiation process. After transfection of the miR-144 mimic, 476 differentially expressed genes (DEGs) were detected by RNA-seq, and these DEGs mainly regulate adrenergic, MAPK, and PI3K-AKT signaling pathways. Further studies revealed that bta-miR-144 targets binding to the NACC1 gene; whereas NACC1 regulates BSMSCs in a manner opposite to bta-miR-144. These findings suggest that miR-144 negatively regulates BSMSCs development by targeting the NACC1gene.
Autosomal dominant stromal corneal dystrophy associated with a SPARCL1 missense variant
Authors: Hardcastle Alison , Braddock Freddie , Gardner Jessica , Bhattacharyya Nihar , Sanchez-Pintado Beatriz , Costa Marcos , Zarouchlioti Christina , Szabo Anita , Lišková Petra , Cheetham Michael , Young Robert , Thaung Caroline , Davidson Alice , Tuft Stephen 
Published: July 2024

Abstract

Corneal dystrophies are phenotypically and genetically heterogeneous, often resulting in visual impairment caused by corneal opacification. We investigated the genetic cause of an autosomal dominant corneal stromal dystrophy in a pedigree with eight affected individuals in three generations. Affected individuals had diffuse central stromal opacity, with reduced visual acuity in older family members. Histopathology of affected cornea tissue removed during surgery revealed mild stromal textural alterations with alcianophilic deposits. Whole genome sequence data was generated for four affected individuals. No rare variants (MAF <0.001) were identified in established corneal dystrophy genes. However, a novel heterozygous missense variant in exon 4 of SPARCL1, NM_004684: c.334G>A; p.(Glu112Lys), which is predicted to be damaging, segregated with disease. SPARC-Like protein 1 (SPARCL1) is a secreted matricellular protein involved in cell migration, cell adhesion, tissue repair, and remodelling. Interestingly, SPARCL1 has been shown to regulate decorin. Heterozygous variants in DCN, encoding decorin, cause autosomal dominant congenital stromal corneal dystrophy, suggesting a common pathogenic pathway. Therefore, we performed immunohistochemistry to compare SPARCL1 and decorin localisation in corneal tissue from an affected family member and an unaffected control. Strikingly, the level of decorin was significantly decreased in the corneal stroma of the affected tissue, and SPARCL1 appeared to be retained in the epithelium. In summary, we describe a novel autosomal dominant corneal stromal dystrophy associated with a missense variant in SPARCL1, extending the phenotypic and genetic heterogeneity of inherited corneal disease.
Structural Characterization of Disulfide-Linked p53-Derived Peptide Dimers
Authors: DiGiorno Magdalena C. , Vithanage Nisansala , Victorio Clara G. , Kreitler Dale F. , Outlaw Victor K. , Sawyer Nicholas 
Published: July 2024

Abstract

Disulfide bonds provide a convenient method for chemoselective alteration of peptide and protein structure and function. We previously reported that mild oxidation of a p53-derived bisthiol peptide (CTFANLWRLLAQNC) under dilute non-denaturing conditions led to unexpected disulfide-linked dimers as the exclusive product. The dimers were antiparallel, significantly α-helical, resistant to protease degradation, and easily reduced back to the original bisthiol peptide. Here we examine the intrinsic factors influencing peptide dimerization using a combination of amino acid substitution, circular dichroism (CD) spectroscopy, and X-ray crystallography. CD analysis of peptide variants suggests critical roles for Leu6 and Leu10 in the formation of stable disulfide-linked dimers. The 1.0 Å resolution crystal structure of the peptide dimer supports these data, revealing a leucine-rich LxxLL dimer interface with canonical knobs-into-holes packing. Two levels of higher-order oligomerization are also observed in the crystal: an antiparallel “dimer of dimers” mediated by Phe3 and Trp7 residues in the asymmetric unit and a tetramer of dimers mediated by Trp7 and Leu10. In CD spectra of Trp-containing peptide variants, minima at 227 nm provide evidence for the dimer of dimers in dilute aqueous solution. Importantly, and in contrast to the original dimer model, the canonical leucine-rich core and robust dimerization of most peptide variants suggests a tunable molecular architecture to target various proteins and evaluate how folding and oligomerization impact various properties, such as cell permeability.
Paraphilic Sexual Fantasies in a Sample of University Students from Southern Brazil
Authors: Furian Gabriel , Schwarz Karine , Canto Gustavo do , Jordani João , Marchi Nino , Beier Klaus Michael , Amelug Till , Lobato Maria Inês 
Published: July 2024

Abstract

Purpose: This study aims to investigate the frequency and the possible correlation between paraphilic fantasies, hypersexuality, childhood trauma, and self-declared sexual orientation in a sample of university students from public and private institutions in Southern Brazil.
Methods: An online questionnaire, through the Google Docs hosting platform, was adapted from the inventory of paraphilic interests and disorders of the Troubled-Desire website. Childhood Trauma Questionnaire, Hypersexual Disorder Screening Inventory was assessed, both in the Brazilian version.
Results: The sample consisted of 572 students, 64% with 18–24 years; 56.5% reported female biological sex and 43.5% male. Regarding gender identity, 55.8% were female, 42.8% male, 1.4% nonbinary, and 0.7% transvestite; 53.1% of the participants declared themselves heterosexual, 31.1% bisexual, and 13.1% homosexual. About 2.4% of the participants defined themselves as pansexual, demisexual, asexual, "I don't know," "doubt," "questioning," and queer. 42.6% of the women declared themselves as bisexual and 6.7% as homosexual, whereas 18% of the men self-declared as bisexual and almost 31% as homosexual; 3.2% of male participants presented diagnoses criteria for hypersexual disorder. The difference in the frequency of hypersexual disorder in men and women was statistically significant (p=0.012). Women were more associated with masochistic sexual fantasy, whereas men were more associated with frotteurism, voyeurism, sadism, pedophilia, and cross-dressing.
Conclusion: This research brings light to the presence of paraphilic fantasies in a sample of university students of Southern Brazil, which was very high, and to the absence of self-declared impairment or suffering, showing that these fantasies may not indicate a mental disorder.
Nutrition Transition Patterns in the Context of Global Food Systems Transformation
Authors: Carducci Bianca , Chen Yixin , Luo Hanqi , Webb Patrick , Fanzo Jess 
Published: July 2024

Abstract

The idea of nutrition transition was critical to conceptualizing patterns of the global burden of malnutrition in line with demographic and epidemiological transitions of the 20th century. However, earlier typologies are less reflective of the nuances which characterize today’s nutrition reality. This analysis presents a new paradigm for conceptualizing nutrition transition that better aligns with food system transitions and with evolving population dynamics. Examining seven nutrition indicators (under-5 stunting, wasting and overweight, adult overweight, anemia in women of reproductive age, adult diabetes and adult raised blood pressure) with national-level estimates between 2013-2023, we explore how food system typologies cluster across 108 countries and identify three distinct population-level patterns which describe a triple burden of malnutrition that manifests differently across the globe. The findings suggest that while Cluster 1 encompasses a large proportion of less industrialized countries from a food systems perspective, Clusters 2 and 3 represent a mosaic of typologies experiencing similar nutrition burdens in middle- and higher-income nations. Therefore, the forces shaping global and local food systems are dynamic and interactive, resulting in outcomes that are less linear and distinct than previous concepts allowed for.
The TikTok Addiction Scale: Development and validation
Authors: Galanis Petros , Katsiroumpa Aglaia , Moisoglou Ioannis , Konstantakopoulou Olympia 
Published: July 2024

Abstract

Introduction: There is an absence of valid and specific psychometric tools to assess TikTok addiction. Considering that the use of TikTok is increasing very rapidly, and the fact that TikTok addiction may be a different form of social media addiction, there is an urge for a valid tool to measure TikTok addiction.
Aim: To develop and validate a tool to measure TikTok addiction among users.
Methods: First, we performed an extensive literature review to create a pool of items to measure TikTok addiction. Then, we employed a panel of experts from different backgrounds to examine the content validity of the initial set of items. We examined the face validity of the scale by performing cognitive interviews with TikTok users and calculating the item-level face validity index. We employed exploratory and confirmatory factor analysis to examine the construct validity of the “TikTok Addiction Scale” (TTAS). We examined the concurrent validity of the TTAS by using the “Bergen Social Media Addiction Scale” (BSMAS), the Patient Health Questionnaire-4 (PHQ-4), and the Big Five Inventory‐10 (BFI‐10). We used Cronbach’s alpha, McDonald’s Omega, Cohen’s kappa, and intraclass correlation coefficient to examine the reliability of the TTAS.
Results: Initially, we developed a pool of 28 items and, after expert panel review and item analysis, we deleted 13 items. Then, we conducted exploratory and confirmatory factor analysis including 15 items to examine the factorial structure of the TTAS. Both analyses confirmed that the final version of the TTAS includes 15 items. Moreover, we found six factors including 15 items; salience (two items), mood modification (two items), tolerance (three items), withdrawal symptoms (two items), conflict (four items), and relapse (two items). Concurrent validity of the TTAS was excellent since we found statistically significant correlations between the TTAS and the BSMAS, the PHQ-4, and the BFI‐10. Cronbach’s alpha and McDonald’s Omega for the TTAS was 0.911 and 0.914, respectively. Cohen’s kappa for the 15 items ranged from 0.760 to 0.954 (p < 0.001 in all cases). Intraclass correlation coefficient for the TTAS was 0.994 (p < 0.001). Thus, the reliability of the TTAS was excellent.
Conclusions: The TTAS is a six-factor 15-item scale with robust psychometric properties. The TTAS is a short and easy-to-use tool that measures levels of TikTok addiction among users in a valid way. Considering the limitations of our study, we recommend the translation and validation of the TTAS in other languages and populations to further examine the reliability and the validity of the scale.
Exploring the Optical, Thermoelectric and Dynamic Properties of AReO3 Perovskite Compounds (A = Cs, Rb, Tl): A DFT and MD Study
Authors: Arumona Arumona Edward , Johnson Austin 
Published: July 2024

Abstract

This study investigates the optical, thermoelectric, and dynamic properties of AReO3 perovskite oxides (A = Cs, Rb, Tl) using density functional theory and molecular dynamics simulations. The optical properties, including reflectivity, joint density of states, refractive index, and absorption coefficient, are calculated and compared across the three materials, revealing distinct characteristics for each compound. Thermoelectric properties such as Seebeck coefficient, electrical conductivity, thermal conductivity, and specific heat capacity are analyzed as functions of temperature and chemical potential. Molecular dynamics simulations are used to examine the dynamic behavior through velocity autocorrelation functions at different temperatures. The results show CsReO3 having the highest reflectivity and refractive index, promising thermoelectric potential, and stable dynamic behavior across temperatures. TlReO3 exhibits the highest absorption coefficient and unique temperature-dependent dynamic behavior. This study provides insights into the potential applications of these rhenium-based perovskite oxides in optoelectronics, thermoelectrics, and high- temperature devices, paving the way for further research in optimizing their properties for specific applications.
Mineralogical fingerprints of crustal silica contamination in the Bayan Obo carbonatite
Authors: Xiao Yulun , Yang Wubin , Yang Xiaoyong , Cao Yonghua , Tian Pengfei , Zhao Zhuang 
Published: July 2024

Abstract
Carbonatites are carbonate-rich and silica-undersaturated igneous rocks. The presence of various silicates in carbonatites has sparked discussions about the source of silica. In this study, abundant fluorbritholite-(Ce) and humite group minerals are identified in the No. 1 carbonatite dike at the Bayan Obo REE-Nb-Fe deposit. These silicates are relatively rare and poorly understood in carbonatite systems. Mineral textures, in-situ EPMA and LA-ICP-MS analyses have been combined to constrain the mineral genesis in the carbonatite. Fluorbritholite-(Ce), member of the apatite super-group, occurs as euhedral to subhedral crystals in the dike. They are characterized by remarkably high concentrations of REE2O3 (56.0-63.7 wt.%), SiO2 (19.6-21.2 wt.%) and F (2.47-3.47 wt.%), along with relatively lower P2O5 (0.25-3.69 wt.%) and CaO (10.3-14.2 wt.%) contents compared to common fluorapatite species. Additionally, their high Y (961-3435 ppm) and low Sr/Y (0.59-2.70) values suggest a hydrothermal origin from a fluid rich in SiO2, REE and F. Humite group minerals, mainly chondrodite and humite, display irregular mineral textures. They also exhibit elevated SiO2 (32.5-34.7 wt.%), and F content (3.59-7.32 wt.%), with notably low TiO2 content (0.02-0.08 wt.%), indicating a hydrothermal origin induced by fenitization in the shallow crust. Our results favor a model of crustal silica contamination for the fenitization fluids, enriched in F, LREE and SiO2. More importantly, the fluid-assisted silica contamination from wall rocks within carbonatites is likely to be a critical trigger of REE deposition in the carbonatite ore-forming systems.
Unusual sulfide-rich magmatic apatite crystals from &gt;2.7 Ga Abitibi Greenstone Belt, Canada
Authors: Meng Xuyang , Mole David R. , Simon Adam C. , Mao Jingwen , Kontak Daniel J. , Jugo Pedro J. , Kleinsasser Jackie M. 
Published: July 2024

Abstract
Sodic volcanoplutonic terranes in the Archean can be well preserved, but why oxidized S-rich sodic magmas and porphyry-type Cu-Au deposits are so rare remains poorly understood. Here we addressed this issue by measuring the S concentration and S6+/ΣS ratio of primary apatite grains in &gt;2.7 Ga felsic volcanic rocks from the well-characterized Neoarchean Abitibi Greenstone Belt of the Superior Province, Canada. Whereas apatite grains in most samples contain low S concentrations (&lt;0.01 wt%, n = 24), a few apatite samples are S-rich (0.14 ± 0.03 wt%, 1σ) and have low S6+/ΣS ratios (0.56 ± 0.17; 1σ, n = 4). Samples with S-poor apatite have variable whole-rock La/Yb ratios (generally &lt;30) and zircon 10000*(Eu/Eu*)/Yb ratios of 11 ± 8 (1σ), which may be products of plume-driven or over-thickened crustal melting. In contrast, the samples with S-rich apatite have elevated La/Yb ratios of 49 ± 15 (1σ), zircon 10000*(Eu/EuN*)/Yb ratios of 26 ± 7 (1σ), and zircon δ18O values of 5.8 ± 0.1 ‰ (1σ), consistent with a deep, hydrous and homogeneous mantle-like source for the melts dominated by amphibole ± garnet fractionation that is reminiscent of subduction-like process. These are the first reported results documenting the predominant accommodation of relatively reduced S in S-rich apatite grains crystallized from terrestrial silicate melts, possibly reflecting slight oxidation associated with the hydration of Neoarchean mantle and crystal fractionation over the magma evolution. The more common S-poor apatite data suggest that suppressed oxidation of the parental sodic magmas led to weak S emission from Earth’s interior to its evolving surface, explaining the rarity of porphyry-type Cu deposits in &gt; 2.7 Ga Archean sodic volcanoplutonic terranes.
Multi-analytical characterization of an unusual epidote-supergroup mineral from Malmkärra, Sweden: Toward the new (OH)-analogue of dollaseite-(Ce)
Authors: Taddei Alice , Bonazzi Paola , Förster Hans-Jürgen , Casey Patrick , Holtstam Dan , Karlsson Andreas , Bindi Luca 
Published: July 2024

Abstract
A study of a skarn sample from the Malmkärra iron mines, Norberg, Västmanland (Sweden) revealed the occurrence of a peculiar epidote-supergroup mineral. It was examined using electron microprobe, single-crystal X-ray diffraction, Mössbauer and Fourier-transform infrared spectroscopy techniques. Structure refinements combined with electron-microprobe data indicate the following cation populations: A1 = Ca0.96REE3+0.03Mn0.01; A2 = REE3+0.99Ca0.01; M1 = Mg0.40Al0.32Fe3+0.26Fe2+0.02; M2 = Al0.98Fe3+0.02; M3 = Mg0.72Fe2+0.17Fe3+0.11; T1,2,3 = Si2.93Al0.07, accounting for a total positive charge of 24.64. The presence of Fe2+ is confirmed by Mössbauer data. The remarkable amount of divalent cations at both M1 and M3 (&gt; 1 pfu, per formula unit) demands more than one monovalent anion pfu in the structure. As the mineral lacks fluorine, charge neutrality must be achieved through additional H+ (about 0.4 apfu). Only one independent hydrogen atom is located within the structure, with O10 as donor and O4 as acceptor, as in other epidote-supergroup minerals. Nonetheless, another O–O distance is suitable for a hydrogen bond, namely O10–O2. Although the existence of the additional OH group was not directly proved by vibrational spectroscopy, FT-IR data provided information related to this potential O10–O2 bridge. In the IR-spectrum acquired, several bands are observed in the OH-stretching region, and a secondary peak at 2140 cm–1 could be assigned to the bending mode of the O10–H…O2 group. To shed light onto this puzzling observation, one single crystal was subjected to annealing experiments at temperatures from 500 to 700°C, in 50°C steps, while a second one has undergone a heat treatment at 700°C. After the heat treatment, the IR-spectrum showed a decrease in intensity of all observed bands, in agreement with a dehydrogenation occurring at high temperatures. Although the structural position of the second hydrogen is still uncertain, it is reasonable to describe the composition of the epidote-supergroup mineral from Malmkärra as a solid solution between dissakisite-(Ce) (32%), ferriallanite-(Ce) (28%) and a yet undescribed end-member (40%), the (OH)-analogue of dollaseite-(Ce) – ideally CaREE3+Mg2AlSi3O11(OH)2.
The Potential Role of Non-coding RNAs in Regulating Ferroptosis in Cancer: Mechanisms and Application Prospects
Authors: Cao Ming-Yuan , Zhang Zhen-Dong , Hou Xin-Rui , Wang Xiao-Ping 
Published: July 2024

:
Cancer is the second leading cause of death globally. Despite some successes, conventional cancer
treatments are insufficient to address the growing problem of drug resistance in tumors and to achieve efficient
treatment outcomes. Therefore, there is an urgent need to explore new therapeutic options. Ferroptosis, a type of
iron- and reactive oxygen species-dependent regulated cell death, has been closely associated with cancer development
and progression. Non-coding RNAs (ncRNAs) are a class of RNAs that do not code for proteins, and
studies have demonstrated their involvement in the regulation of ferroptosis in cancer. This review aims to explore
the molecular regulatory mechanisms of ncRNAs involved in ferroptosis in cancer and to emphasize the
feasibility of ferroptosis and ncRNAs as novel therapeutic strategies for cancer. We conducted a systematic and
extensive literature review using PubMed, Google Scholar, Web of Science, and various other sources to identify
relevant studies on ferroptosis, ncRNAs, and cancer. A deeper understanding of ferroptosis and ncRNAs could
facilitate the development of new cancer treatment strategies.