bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rhythmic transcranial magnetic stimulation in the treatment of cervical dystonia and comorbid mental disorders
Authors: Ragimova A. A. , Petelin D. S. , Galyautdinova A. N. , Tolmacheva V. A. , Volel B. A. 
Published: June 2024

Cervical dystonia (CD) is a common form of movement disorder with a high incidence of comorbid mental disorders. Rhythmic transcranial magnetic stimulation (rTMS) is effective in depression and other mental disorders, but its efficacy in CD with comorbid mental disorders has been poorly studied.Objective: to investigate the efficacy of rTMS in CD and comorbid mental disorders.Material and methods. Seventeen patients with CD underwent a course of 10 rTMS sessions (protocol: 1 Hz, 600 pulses to the left primary motor cortex). The severity of mental disorders, quality of life and severity of cervical dystonia were assessed using the HADS, SF-36 and CDQ-24 scales.Results. After transcranial magnetic stimulation treatment, a significant reduction in anxiety (from 12.2±4.1 to 6.3±2.1 points; p<0.01) and depression (from 8.4±3.7 to 5.2±3.2 points; p<0.01) on the HADS scale were noted, and a significant improvement in both physical (from 37±15.2 to 45±17.3 points; p=0.017) and mental (from 31±11.2 to 38±9.6 points; p=0.008) quality of life components according to SF-36. The severity of CD according to CDQ-24 also decreased significantly (from 60.2±11.7 to 51±12.4 points; p=0.022), and there were improvements in the subscales of emotional well-being and social and family life.Conclusion. The efficacy of rTMS in reducing the severity of both manifestations of CD and comorbid mental disorders was established.
Analyzing the predictors of relapse in drug-induced headache: a prospective clinical and psychological study
Authors: Guziy E. A. , Sergeev A. V. , Tabeeva G. R. 
Published: June 2024

The prevalence of drug-induced headache (DIHA) in the population is about 7%, and the relapse rate of DIHA after successful treatment is about 40% within 5 years.Objective: to analyze the risk factors for recurrence of DIHA and to develop a prognostic model for the probability of relapse after treatment.Material and methods. The characteristics of 117 patients with DIHA were analyzed on the basis of clinical data and questionnaire data using headache scales (MMAS-8, MIDAS, HALT, HIT-6, mTOQ-5), psycho-emotional profiles (PCS, Spielberger-Hanin Anxiety Scale, PHQ-9, BIS-11, TAS-26, SAGE test, LDQ) that were performed at the time of admission to the clinic and 9 months after the start of therapy. All patients enrolled in the study received a complex treatment that included an educational conversation, “detoxification” and symptomatic therapy during the withdrawal period along with a preventive treatment for chronic migraine (CM).Results. It was shown that there is still a low level of diagnosing of CM and DIHA. By creating a prediction model for the likelihood of recurrence of DIHA, we were able to identify the most important factors for an unfavorable course and recurrence of excessive analgesics use: frequency of analgesic use per day (OR 15.8; 95% C113.1—23.4), degree of alexithymia (score on TAS-26 scale: OR 11.3; 95% CI 6.3—18.1), frequency of combined analgesic use per month (OR 7.1; 95% CI 4.3—11.7), degree of pain catastrophizing on the PCS scale (OR 4.7; 95% CI 1.2—7.3), duration of symptomatic drug abuse (OR 3.2; 95% CI2.1—5.7).Conclusion. A high level of concomitant psychoemotional disorders, especially alexithymia and impulsive behaviour, is a significant risk factor for relapse and should be considered in the treatment of comorbid pathologies. It can be assumed that monoclonal antibodies against calcitonin gene-related peptides, botulinum therapy or combined treatment may be the treatment of choice in cases of ineffective prevention and detoxification attempts in the past as well as in cases of prolonged analgesic abuse.
Optic neuritis in various demyelinating diseases
Authors: Kalashnikova A. K. , Eliseeva D. D. , Andreeva N. A. , Zhorzholadze N. V. , Ronzina I. A. , Bembeeva R. Ts. , Venediktova N. N. , Kalganova M. R. , Sheremet N. L. 
Published: June 2024

The discovery of antibodies against aquaporin-4 (AQP4) and against myelinoligodendrocyte glycoprotein (MOG) confirmed the existence of two disease entities distinct from multiple sclerosis (MS) — neuromyelitis optica spectrum disorders (NMOSD) and myelinoligodendrocyte glycoprotein-associated disease (MOGAD). Demyelinating optic neuritis (ON) can be either idiopathic (iDON) or a manifestation of MS, NMOSD (AQP4-ON) or MOGAD (MOG-ON).Objective: to determine the clinical features of ON and to evaluate the diagnostic value of optical coherence tomography (OCT) in demyelinating diseases of the central nervous system.Material and methods. The study included 43 patients with demyelinating ON who were divided into three groups according to the underlying disease (NMOSD, MOGAD and MS/iDON). We assessed visual acuity (VA) in the acute phase and analyzed VA and average values of retinal nerve fiber layer thickness (RNFL) and retinal ganglion cell complex (RGC) thickness using OCT data 6 months after the onset of ON.Results. ON was observed in the onset of the disease in 75% of NMOSD patients, 62% of MOGAD patients and 86% of MS/iDON patients. In the MOGAD and NMOSD groups, bilateral ON was predominantly observed. In 65% of patients with MOGAD (MOG-ONr), a recurrent course of ON was observed. VA was significantly lower in patients with AQP4-ON in acute phase and comparable to the MOG-ONr group in the long-term phase. VA in the onset of MOG-ON with a single episode was comparable to that of MS/iDON (p=0.2), but recovery was less pronounced (p=0.03). The most significant thinning of the RNFL and RGC complex was observed in the AQP4-ON and MOG-ONr groups. In AQP4-ON and MOG-ON groups, restoration of VA up to 0.5 and higher was observed significantly more frequently in the group of patients receiving pulse therapy with glucocorticoids (p=0.018).Conclusion. The study showed the most pronounced structural and functional disturbances in the long-term phase of AQP4-ON and MOG-ONr. MOG-ON was characterized by a high frequency of relapses with the influence of this factor on VA and thinning of the retinal layers in the long-term.
The influence of the mental state of women with infertility on their reproductive status
Authors: Nikolaevskaya A. O. , Tyuvina N. A. , Balabanova V. V. 
Published: June 2024

Mutual influence between women's mental health and their reproductive capacity are not clearly understood. In particular, psychogenic factors and mental disorders affect sexual, menstrual and reproductive functions, which in turn can lead to infertility. Improving the mental state of women, on the other hand, helps to restore reproductive function.Objective: to develop dynamic ideas about the reproductive status of mentally ill and mentally healthy women with infertility based on the results of the follow-up.Material and methods. The study included 348 patients with infertility over a period of 2 years, 228 were mentally healthy women and 120 women with mental disorders. All women were consulted by a gynecologist, women with mental disorders by a psychiatrists, and treatment of existing disorders was carried out.Results. Mentally healthy women have a significantly higher number of pregnancies, which is mainly due to the in vitro fertilization procedure. They have a rational approach to pregnancy planning, are characterized by a high referral rate to obstetricians and gynecologists and undergo a large number of gynecological procedures to overcome infertility. Pregnancy occurs spontaneously in mentally ill patients and is associated with an improvement in mental state and normalization of menstrual, sexual and therefore reproductive function, but is characterized by a complicated course (fetal growth retardation, miscarriage, intrauterine infection of the fetus, oedema, hypertension, lipid metabolism disorders, gestational diabetes mellitus, placental disorders) and fewer births.Conclusion. The reproductive function of women depends on their mental state. In women with mental disorders, disturbances of menstrual and sexual function and family adaptation lead to infertility. Improving the mental state contributes to the restoration of reproductive function and spontaneous pregnancy.
Fremanezumab in real-life clinical practice: specialized headache center experience
Authors: Azimova Yu. E. , Skorobogatikh K. V. , Osipova V. V. , Korobkova D. Z. , Vashchenko N. V. , Mamkhegov E. Z. , Galanina A. S. , Guziy E. A. 
Published: June 2024

Anti-CGRP monoclonal antibodies (mAb) have been approved and successfully used in Russia since 2020.Objective: to investigate the efficacy and safety of fremanezumab (FRE) therapy (225 mg monthly or 675 mg quarterly) in real-life clinical practice in patients with migraine who referred to a specialized Russian headache center.Material and methods. This open-label, retrospective study involved 202 patients (mean age 39.4±12.2 years) with frequent episodic (EM) or chronic migraine (CM) who received at least three injections of FRE 225 mg or three injections with a total dose of 675 mg and regularly completed the Migrebot headache diary one month before starting therapy and throughout the course of treatment.Results. The mean number of migraine days per month decreased in the whole group from 20.1±8.2 (before treatment) to 8.5±7.9 after 12 weeks (p<0.0001), in the EM group from 10.9±4.1 to 3.6±3.7 (p<0.0001) and in the CM group - from 24.4±5.7 to 10.8±8.3 (p<0.0001). Adverse events were observed in 13 (6.4%) patients (most frequently local reactions: itching, rash, redness, induration at the injection site).Conclusion. The study showed a favourable efficacy and safety profile of FRE in the Russian population, where anti-CGRP mAbs are considered the first-line treatment for migraine.
Therapeutic outcomes in patients with acute non-specific (musculoskeletal) pain according to the FORTE (ФОРТЕ) observational study
Authors: Parfenov V. A. 
Published: June 2024

Treatment of acute non-specific back pain (ANSBP) is one of the current issues of modern medicine, as ANSBP is one of the most common causes of temporary disability in the population. Non-steroidal anti-inflammatory drugs (NSAIDs) are used in ANSBP , with the drug Nalgesin® forte (naproxen 550 mg) being widely used in clinical practice.Objective: to evaluate the efficacy and safety of the drug Nalgesin® forte in patients with ANSBP.Material and methods. The observational study “Nalgesin® forte (naproxen) in real-life clinical practice: treatment outcomes in patients with acute non-specific (musculoskeletal) pain” included 12,434 patients (46.51% men, 53.49% women; mean age of patients – 47.3±13.8 years) with ANSBP. Pain in the lumbar region and in the neck prevailed (lumbodynia – 25.5%, lumboischialgia – 26.28%, cervicalgia – 33.03%), less frequently the pain was localized in the thoracic region (thoracalgia – 15.18%). We assessed pain intensity using numeric rating scale (NRS), indicators of the Russian version of the Kiel questionnaire, duration of therapy with Nalgesin® forte, satisfaction with the therapy and tolerability of the treatment. The patients were informed about the benign nature of the ANSBP and took the medication Nalgesin® forte 550 mg 1–3 times a day for pain relief; the medication was discontinued when the pain resolved or decreased significantly.Results. The majority (75.9%) of patients received Nalgesin® forte at a dose of 550 mg twice daily, 14.3% – 550 mg once daily and 9.8% – 550 mg three times daily. The duration of therapy was 6–14 days in the majority (80.03%) of patients, while it did not exceed 1 week in more than one third of patients (37.2%). During treatment, the average pain intensity decreased from 6.6±1.60 to 1.82±1.32 points according to the NRS (p<0.001), the proportion of patients with initially unbearable pain decreased from 2.79 to 0.28%, with severe pain – from 27.16 to 1.10%, with moderate pain – from 60.42 to 2.82%, and the proportion of patients with mild pain increased from 9.63 to 95.8% (p<0.001). Most physicians (91.7%) were satisfied with the treatment results, and most patients (94.5%) and physicians (95.7%) were satisfied with the tolerability of the treatment. Patients with a high and medium risk of chronic pain according to the Kiel questionnaire required longer treatment than patients with a low risk of chronic pain (p=0.002). A low incidence of adverse events (AEs) was observed when taking Nalgesin® forte; no serious AEs were recorded.Conclusion. Favourable therapeutic outcomes in ANSBP, efficacy and safety of the drug Nalgesin® forte in ANSBP of different localisations were noted.
On an Optimal AFEM for Elastoplasticity
Authors: Schönauer Miriam , Schröder Andreas 
Published: June 2024

Abstract
In this paper, optimal convergence for an adaptive finite element algorithm for elastoplasticity is considered. To this end, the proposed adaptive algorithm is established within the abstract framework of the axioms of adaptivity [C. Carstensen, M. Feischl, M. Page and D. Praetorius,
Axioms of adaptivity,
Comput. Math. Appl. 67 2014, 6, 1195–1253], which provides a specific proceeding to prove the optimal convergence of the scheme. The proceeding is based on verifying four axioms, which ensure the optimal convergence. The verification is done by using results from [C. Carstensen, A. Schröder and S. Wiedemann,
An optimal adaptive finite element method for elastoplasticity,
Numer. Math. 132 2016, 1, 131–154], which presents an alternative approach to optimality without explicitly relying on the axioms
Kat\v{e}tov--Blass order and measurable filters on ℕ
Authors: Millán Andres 
Published: June 2024

Abstract
In this note we consider a family

𝖪𝖡𝖭

{\sf KBN}

of filters on ω which are null, with respect to
the standard product measure on

2
ω

{2^{\omega}}

in some
strong sense and we prove in

𝖹𝖥𝖢

{{\sf ZFC}}

that this class
includes all universally measurable filters.
Also, we construct

2
𝔠

{2^{\mathfrak{c}}}

-many

𝖪𝖡𝖭

{\sf KBN}

filters which are not universally measurable
and show that
the Filter Dichotomy Principle (

𝖥𝖣𝖯

{{\sf FDP}}

)
of A. Blass and C. Laflamme implies that
every member of

𝖪𝖡𝖭

{\sf KBN}

is meager.
In addition, we prove that if the identity

min
⁡

{

𝖺𝖽𝖽
⁢

(
𝒩
)

,
𝔱
}

=
𝔡

{\min\{{\sf add}(\mathcal{N}),\mathfrak{t}\}=\mathfrak{d}}

holds,
there are non-meager filters in

𝖪𝖡𝖭

{\sf KBN}

.
Thus, the existence of non-meager

𝖪𝖡𝖭

{\sf KBN}

filters
is independent of the axioms of

𝖹𝖥𝖢

{{\sf ZFC}}

.
On the geometry of semi-slant submanifolds of a conformal Kenmotsu manifold
Authors: Siddesha M. S. , Bagewadi C. S. , Ramesha M. 
Published: June 2024

Abstract
The object of this paper is to conduct an in-depth
examination of semi-slant submanifolds within the framework of a
conformal Kenmotsu manifolds. Our investigation is centered around
identifying and understanding the conditions that ensure the
integrability of both invariant and slant distributions, which play
a pivotal role in defining semi-slant submanifolds. Additionally, we
prove some interesting results for semi-slant submanifolds with
parallel canonical structures.
Fetal bradyarrhythmias: classification, monitoring and outcomes of 40 cases at a single center
Authors: Demirci Oya , Gezer Murad , Tosun Öykü 
Published: June 2024

Abstract

Objectives
To assess congenital fetal bradyarrhythmias with regard to etiological causes, features, risk factors, and prognosis.

Methods
This retrospective study involved fetuses with fetal bradyarrhythmias. All fetuses were evaluated by ultrasonography. Parental ECGs and family histories were obtained, and maternal autoantibodies were measured. Gestational age at diagnosis, fetal atrial and ventricular rates at presentation, type of bradyarrhythmias, the presence or absence of a congenital heart defect (CHD), fetal hydrops, fetal myocardial dysfunction, extra-cardiac abnormalities, maternal autoimmune diseases, maternal autoantibodies as well as prenatal treatment, and neonatal outcome were collected.

Results
Of the 40 fetuses included in the study, 11 had maternal rheumatologic disease, 16 had complex cardiac anomalies such as left and right isomerism. Fetuses with CHD significantly differed from those without CHD with increased rates of extra-cardiac anomalies, hydrops, fetal deaths and shorter survival after 28 days (p<0.05). Survival was significantly better in fetuses with maternal rheumatic disease as compared with those with no maternal rheumatic disease (p<0.05). Maternal anti-arrhythmic therapy was administered in 11 fetuses. In utero maternal treatment resulted in no significant difference in the course of arrhythmia or hydrops in fetuses with or without maternal rheumatic disease (p<0.05). In regression analysis, the absence of fetal hydrops was the only independent factor associated with survival (p=0.04).

Conclusions
The course of bradyarrhythmias, along with survival, seems to be more favorable in fetuses with maternal rheumatic disease than in those with CHD, especially left and right isomerism. Hydrops was the sole independent factor associated with poor survival.
A short report on a probability-based interpretation of quantum mechanics
Authors: Rocchi Paolo 
Published: June 2024

Abstract
This study calls attention to the current state of the probability (P) domain which presents weak points at the mathematical level and more significant flaws at the application level. Popper noticed how fundamental issues raised in quantum mechanics (QM) directly derive from unresolved probabilistic questions. Endless philosophical debates create more problems than solutions, so the author of this research suggests going directly to the root of the issues and searching for the probability theory which formalizes the multifold nature of P. This study offers a brief overview of the structural theory of probability, recently published in a book, and applies it to QM in order to show its completeness. The whole probability-based interpretation of QM goes beyond the limits of a paper and these pages condense a few aspects of this theoretical scheme. The double slit experiment is used to corroborate the theorems presented here.
Quality Improvement Project Reducing Sputum Cultures for Pediatric Patients With a Tracheostomy
Authors: Harris Baila , Kern Kristina , Benner Christopher , Moses James , Artinian Hovig 
Published: June 2024

BACKGROUND AND OBJECTIVES
Current research implies overuse of diagnostic testing and overtreatment in children with tracheostomies. There are no guidelines for obtaining sputum cultures for these patients, yet they are commonly obtained without significantly affecting management or outcomes. The aim of our quality improvement project was to decrease rate of sputum cultures in this population by 50%, from 64% to 32%.

METHODS
This was a single-center quality improvement project conducted in a pediatric emergency department (ED). Key drivers included: Standardized decision-making, appropriate culture collection, knowledge regarding colonization versus clinically relevant growth, and viral versus bacterial infections in this population. The study team developed an algorithm, used modification to electronic medical records orders, and provided education to drive change. Six months of preintervention and 12 months postintervention data were collected. Run charts/statistical process charts were created for the rate of cultures, length of stay, and return to the ED.

RESULTS
There were 159 patient encounters and the rate of sputum cultures decreased from 64% at baseline to 25% without change in length of stay or increased rate at which patients returned to the ED, including during local coronavirus disease 2019 and respiratory syncytial virus surges. We observed nonrandom data patterns after introduction of algorithm resulting in centerline shifts.

CONCLUSIONS
The study team was able to introduce an algorithm coinciding with a reduction in number of sputum cultures obtained. Next steps would be determining safety and efficacy of such an algorithm over a larger population.
Psychological Outcomes in Families of PICU Survivors: A Meta-Analysis
Authors: Ko Michelle Shi Min , Lee Wai Kit , Sultana Rehena , Murphy Beverly , Heng Katrina Yi Ching , Loh Sin Wee , Poh Pei Fen , Lee Jan Hau 
Published: June 2024

BACKGROUND
Pediatric critical illness exposes family members to stressful experiences that may lead to subsequent psychological repercussions.

OBJECTIVE
To systematically review psychological outcomes among PICU survivors’ family members.

DATA SOURCES
Four medical databases (PubMed, Embase, CINAHL and PsycInfo) were searched from inception till October 2023.

STUDY SELECTION
Studies reporting psychological disorders in family members of PICU patients with at least 3 months follow-up were included. Family members of nonsurvivors and palliative care patients were excluded.

DATA EXTRACTION
Screening and data extraction was performed according to PRISMA guidelines. Data were pooled using a random-effects model.

RESULTS
Of 5360 articles identified, 4 randomized controlled trials, 16 cohort studies, and 2 cross-sectional studies were included (total patients = 55 597; total family members = 97 506). Psychological distress was reported in 35.2% to 64.3% and 40.9% to 53% of family members 3 to 6 months and 1 year after their child’s PICU admission, respectively. Post-traumatic stress disorder was diagnosed in 10% to 48% of parents 3 to 9 months later. Parents that experienced moderate to severe anxiety and depression 3 to 6 months later was 20.9% to 42% and 6.1% to 42.6%, respectively. Uptake of mental counseling among parents was disproportionately low at 0.7% to 29%. Risk factors for psychiatric morbidity include mothers, parents of younger children, and longer duration of PICU stay.

LIMITATIONS
The majority of studies were on parents with limited data on siblings and second degree relatives.

CONCLUSIONS
There is a high burden of psychological sequelae in family members of PICU survivors. Risk stratification to identify high-risk groups and early interventions are needed.
Transmission-scanning electron microscopy of interface fracture of ferrite deformation twins
Authors: Koko Abdalrhaman , Marrow T. James 
Published: June 2024

AbstractDeformation twins in the ferrite matrix of an age-hardened duplex stainless steel have been observed using on-axis transmission Kikuchi diffraction (TKD) in a scanning electron microscope. This provided details of the lattice misorientation and dislocation arrangement, including the dislocation-free zone at the twin tip. These observations provide evidence for the link between microcracking of the irregular twin/parent interface and relaxation of the residual strains that arise from twin growth, offering new insights into fracture mechanics in these materials.
Graphical abstract