bluuebunny/crossref_metadata_2025_split huggingface dataset:
Highly Ordered Nanoporous Films from Supramolecular Diblock Copolymers with Hydrogen‐Bonding Junctions
Authors: Montarnal Damien , Delbosc Nicolas , Chamignon Cécile , Virolleaud Marie‐Alice , Luo Yingdong , Hawker Craig J. , Drockenmuller Eric , Bernard Julien 
Published: July 2015

AbstractWe designed efficient precursors that combine complementary associative groups with exceptional binding affinities and thiocarbonylthio moieties enabling precise RAFT polymerization. Well defined PS and PMMA supramolecular polymers with molecular weights up to 30 kg mol−1 are synthesized and shown to form highly stable supramolecular diblock copolymers (BCPs) when mixed, in non‐polar solvents or in the bulk. Hierarchical self‐assembly of such supramolecular BCPs by thermal annealing affords morphologies with excellent lateral order, comparable to features expected from covalent diblock copolymer analogues. Simple washing of the resulting materials with protic solvents disrupts the supramolecular association and selectively dissolves one polymer, affording a straightforward process for preparing well‐ordered nanoporous materials without resorting to crosslinking or invasive chemical degradations.
One‐Pot Cannizzaro Cascade Synthesis of ortho‐Fused Cycloocta‐2,5‐dien‐1‐ones from 2‐Bromo(hetero)aryl Aldehydes
Authors: Burroughs Laurence , Eccleshare Lee , Ritchie John , Kulkarni Omkar , Lygo Barry , Woodward Simon , Lewis William 
Published: July 2015

AbstractAn intramolecular Cannizzaro‐type hydride transfer to an in situ prepared allene enables the synthesis of ortho‐fused 4‐substituted cycloocta‐2,5‐dien‐1‐ones with unprecedented technical ease for an eight‐ring carboannulation. Various derivatives could be obtained from commercially available (hetero)aryl aldehydes, trimethylsilylacetylene, and simple propargyl chlorides in good yields.
Protein Delivery System Containing a Nickel‐Immobilized Polymer for Multimerization of Affinity‐Purified His‐Tagged Proteins Enhances Cytosolic Transfer
Authors: Postupalenko Viktoriia , Desplancq Dominique , Orlov Igor , Arntz Youri , Spehner Danièle , Mely Yves , Klaholz Bruno P. , Schultz Patrick , Weiss Etienne , Zuber Guy 
Published: July 2015

AbstractRecombinant proteins with cytosolic or nuclear activities are emerging as tools for interfering with cellular functions. Because such tools rely on vehicles for crossing the plasma membrane we developed a protein delivery system consisting in the assembly of pyridylthiourea‐grafted polyethylenimine (πPEI) with affinity‐purified His‐tagged proteins pre‐organized onto a nickel‐immobilized polymeric guide. The guide was prepared by functionalization of an ornithine polymer with nitrilotriacetic acid groups and shown to bind several His‐tagged proteins. Superstructures were visualized by electron and atomic force microscopy using 2 nm His‐tagged gold nanoparticles as probes. The whole system efficiently carried the green fluorescent protein, single‐chain antibodies or caspase 3, into the cytosol of living cells. Transduction of the protease caspase 3 induced apoptosis in two cancer cell lines, demonstrating that this new protein delivery method could be used to interfere with cellular functions.
Giant Magnetoresistance in the Half‐Metallic Double‐Perovskite Ferrimagnet Mn2FeReO6
Authors: Li Man‐Rong , Retuerto Maria , Deng Zheng , Stephens Peter W. , Croft Mark , Huang Qingzhen , Wu Hui , Deng Xiaoyu , Kotliar Gabriel , Sánchez‐Benítez Javier , Hadermann Joke , Walker David , Greenblatt Martha 
Published: July 2015

AbstractThe first transition‐metal‐only double perovskite compound, Mn2+2Fe3+Re5+O6, with 17 unpaired d electrons displays ferrimagnetic ordering up to 520 K and a giant positive magnetoresistance of up to 220 % at 5 K and 8 T. These properties result from the ferrimagnetically coupled Fe and Re sublattice and are affected by a two‐to‐one magnetic‐structure transition of the Mn sublattice when a magnetic field is applied. Theoretical calculations indicate that the half‐metallic state can be mainly attributed to the spin polarization of the Fe and Re sites.
Ultrathin Co3S4 Nanosheets that Synergistically Engineer Spin States and Exposed Polyhedra that Promote Water Oxidation under Neutral Conditions
Authors: Liu Youwen , Xiao Chong , Lyu Mengjie , Lin Yue , Cai Weizheng , Huang Pengcheng , Tong Wei , Zou Youming , Xie Yi 
Published: July 2015

AbstractDevelopment of efficient and affordable electrocatalysts in neutral solutions is paramount importance for the renewable energy. Herein, we report that the oxygen evolution reaction (OER) performance of Co3S4 under neutral conditions can be enhanced by exposed octahedral planes and self‐adapted spin states in atomically thin nanosheets. A HAADF image clearly confirmed that the active octahedra with Jahn–Teller distortions were exposed exclusively. Most importantly, in the atomically thin nanosheets, the spin states of Co3+ in the octahedral self‐adapt from low‐spin to high‐spin states. As a result, the synergistic effect endow the Co3S4 nanosheets with superior OER performance, with exceptional low onset overpotentials of circa 0.31 V in neutral solutions, which is state‐of‐the‐art among inorganic non‐noble metal compounds.
Vinylation of Unprotected Phenols Using a Biocatalytic System
Authors: Busto Eduardo , Simon Robert C. , Kroutil Wolfgang 
Published: July 2015

AbstractReadily available substituted phenols were coupled with pyruvate in buffer solution under atmospheric conditions to afford the corresponding para‐vinylphenol derivatives while releasing only one molecule of CO2 and water as the by‐products. This transformation was achieved by designing a biocatalytic system that combines three biocatalytic steps, namely the CC coupling of phenol and pyruvate in the presence of ammonia, which leads to the corresponding tyrosine derivative, followed by deamination and decarboxylation. The biocatalytic transformation proceeded with high regioselectivity and afforded exclusively the desired para products. This method thus represents an environmentally friendly approach for the direct vinylation of readily available 2‐, 3‐, or 2,3‐disubstituted phenols on preparative scale (0.5 mmol) that provides vinylphenols in high yields (65–83 %).
Boronic acid‐based thin films that show saccharide‐responsive multicolor changes
Authors: Iwami Yuto , Yokozawa Takenori , Yamamoto Hiroki , Kanekiyo Yasumasa 
Published: July 2015

ABSTRACTA novel saccharide sensor that displays a distinct color change resembling a “traffic signal” was developed. By copolymerizing boronic acid and amine monomers on a glass plate, a boronic acid‐containing thin film was obtained. Anionic blue and yellow dyes were adsorbed on the thin film, and the film was immersed in aqueous saccharide solutions containing a cationic red dye. With increase in the saccharide concentration in the solution, the thin film changes color from green to red via yellow. The observed distinct changes in color were attributed to a stepwise release and binding of dyes. The sensitivity of the saccharide sensor was dependent on the monomer composition of the thin film and increased with increasing the boronic acid content. The pH of the saccharide solution was another key factor affecting the sensing behavior, and glucose‐responsive color changes were significantly enhanced at pH 7.8. By optimizing these conditions, significant color changes in response to glucose were achieved. Saccharide selectivity was found to be in the following order: fructose > glucose > galactose = mannose > sucrose. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42679.
Controlled electrochemical synthesis of conductive nanopolypyrrole and its application in the design of a solid‐state ion sensor
Authors: Das Ishwar , Agrawal Namita Rani , Pandey Avinash Kumar , Choudhary Rinki , Pandey P. C. 
Published: July 2015

ABSTRACTA polypyrrole (PPy) conductive polymer was electrochemically synthesized from pyrrole–cupric chloride (CuCl2)–H2O (system A) and pyrrole–CuCl2–sodium dodecyl sulfate–H2O (system B). Their morphologies and growth behavior were studied, and their aggregates were characterized by powder X‐ray diffraction, scanning electron microscopy, transmission electron spectroscopy, thermogravimetry, and Fourier transform infrared studies. The powder X‐ray diffraction pattern showed only one peak characteristic of PPy. In system B, the dimensions of the fractal patterns were calculated and found to be very close to the theoretical value of diffusion‐limited aggregation. Various morphological transitions were observed at different field intensities and CuCl2 concentrations. Transmission electron spectroscopy studies revealed the formation of nanosized spherical particles 5–10 nm in size. For system B, a potassium‐ion‐selective electrode was constructed on the basis of a dibenzo‐18‐crown‐6 impregnated poly(vinyl chloride) matrix membrane over a synthesized polymer‐modified electrode. The electrode showed Nernstian behavior with a slope of 57 mV; this revealed the potential application of the as‐synthesized material in the design of a solid‐state ion‐selective electrode. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42729.
Calcium Carbonate Mineralized Nanoparticles as an Intracellular Transporter of Cytochrome c for Cancer Therapy
Authors: Koo Ahn Na , Min Kyung Hyun , Lee Hong Jae , Jegal Jun Ho , Lee Jae Won , Lee Sang Cheon 
Published: July 2015

AbstractA new intracellular delivery system based on an apoptotic protein‐loaded calcium carbonate (CaCO3) mineralized nanoparticle (MNP) is described. Apoptosis‐inducing cytochrome c (Cyt c) loaded CaCO3 MNPs (Cyt c MNPs) were prepared by block copolymer mediated in situ CaCO3 mineralization in the presence of Cyt c. The resulting Cyt c MNPs had a vaterite polymorph of CaCO3 with a mean hydrodynamic diameter of 360.5 nm and exhibited 60 % efficiency for Cyt c loading. The Cyt c MNPs were stable at physiological pH (pH 7.4) and effectively prohibited the release of Cyt c, whereas, at intracellular endosomal pH (pH 5.0), Cyt c release was facilitated. The MNPs enable the endosomal escape of Cyt c for effective localization of Cyt c in the cytosols of MCF‐7 cells. Flow cytometry showed that the Cyt c MNPs effectively induced apoptosis of MCF‐7 cells. These findings indicate that the CaCO3 MNPs can meet the prerequisites for delivery of cell‐impermeable therapeutic proteins for cancer therapy.
Resolution of enantiomers of bupropion and its metabolites by liquid chromatography
Authors: Batra Sonika , Bhushan Ravi 
Published: July 2015

AbstractBupropion, a tricyclic aminoketone, is used primarily in the treatment of depression, the management of patients with bipolar and schizo‐affective disorder, and the treatment of Parkinson's disease. Bupropion is marketed as a racemate, but the racemic mixture is known to have several disadvantages while the two isomers of bupropion and its metabolite differ significantly in their pharmacological activities. Therefore, the stereoselective determination of the drug enantiomers in pharamaceutical dosages, plasma or urine is of potential clinical and analytical importance. Different chromatographic methods have been employed for the separation of the two enantiomers. This is the first attempt to review the methods of enantiosepartion of bupropion using both direct and indirect approaches in both HPLC and TLC. The review presents a detailed discussion on the use of chiral stationary phase (based on polysaccharide, α1 acid glycoprotein and ovomucoid column) and chiral derivatizing reagents (based on isothiocyanate and cyanuric chloride) along with TLC separation of bupropion enantiomers using ligand exchange and impregnation methods. The focus is also on the separation mechanism for enantioresolution using the various methods described herein. Copyright © 2015 John Wiley & Sons, Ltd.
Quantitative analysis of 3‐OHB[a]P and (+)‐anti‐BPDE as biomarkers of B[a]P exposure in rats
Authors: Lin Qi , Xiao‐Chen Liu , Bo Yang , Na Liu , Min Shi , Gang Chen , Hui Liu , Jie Zhou , Fa‐Sheng Li 
Published: July 2015

AbstractThe aim of this study was to develop an analytical method for the determination the levels of metabolites of benzo[a]pyrene (B[a]P), 3‐hydroxybenzo(a)pyrene (3‐OHB[a]P) and (+)‐anti‐benzo(a)pyrene diol‐epoxide [(+)‐anti‐BPDE, combined with DNA to form adducts], in rat blood and tissues exposed to B[a]P exposure by high‐performance liquid chromatography with fluorescence detection (HPLC/FD), and to investigate the usefulness of 3‐OHB[a]P and (+)‐anti‐BPDE as markers of intragastrical exposure to B[a]P in rats. The levels of 3‐OH‐B[a]P and B[a]P‐tetrol I‐1 released after acid hydrolysis of (+)‐anti‐BPDE in the samples were measured by HPLC/FD. The calibration curves were linear (r2 > 0.9904), and the lower limit of quantification ranged from 0.34 to 0.45 ng/mL for 3‐OHB[a]P and from 0.43 to 0.58 ng/mL for (+)‐anti‐BPDE. The intra‐ and inter‐day stability assay data suggested that the method is accurate and precise. The recoveries of 3‐OHB[a]P and (+)‐anti‐BPDE were in the ranges of 73.6 ± 5.0 to 116.5 ± 6.3% and 73.3 ± 8.5 to 141.2 ± 13.8%, respectively. A positive correlation was found between the concentration of intragastrical B[a]P and the concentrations of 3‐OH‐B[a]P and (+)‐anti‐BPDE in the blood and in most of the tissues studied, except for the brain and kidney, which showed no correlation between B[a]P and 3‐OHB[a]P and between B[a]P and (+)‐anti‐BPDE, respectively. A sensitive, reliable and rapid HPLC/FD was developed and validated for analysis of 3‐OHB[a]P and (+)‐anti‐BPDE in rat blood and tissues. There was a positive correlation between the concentration of 3‐OHB[a]P or (+)‐anti‐BPDE in the blood and the concentration of 3‐OHB[a]P or (+)‐anti‐BPDE in the most other tissues examined. The concentration of 3‐OHB[a]P or (+)‐anti‐BPDE in the blood could be used as an indicator of the concentration of 3‐OHB[a]P or (+)‐anti‐BPDE in the other tissues in response to B[a]P exposure. These results demonstrate that 3‐OHB[a]P and (+)‐anti‐BPDE are potential biomarkers of B[a]P exposure, which would also be useful to assess the carcinogenic risks from B[a]P exposure. Copyright © 2015 John Wiley & Sons, Ltd.
Determination of the chemical constituents of the different processed products of Anemarrhena asphodeloides Rhizomes by high‐performance liquid chromatography quadrupole time‐of‐flight mass spectrometry
Authors: Peng Ying , Zhao Lulu , Lin Dongju , Liu Yuyang , Zhang Mengyu , Song ShaoJiang 
Published: July 2015

AbstractIn this work, high‐performance liquid chromatography (HPLC) coupled with a hybrid quadrupole time of‐flight mass spectrometry (Q‐TOF‐MS/MS) was used to study chemical compositions of different processed products of Rhizoma Anemarrhenae (RA). A Grace AlltimaTM C18 column (250 × 4.6 mm, 5 µm) was used for separation. Mobile phase consisted of 0.1% formic acid and acetonitrile, using gradient elution. ESI‐MS data was acquired in both positive and negative mode. The experiment was established on the basis of a series of reference substances (two xanthone and seven saponins) to qualitatively identify the chemical compounds of different processed products of RA by MS analysis. There was no difference in the type of chemical constituents between different processed products of RA. A total of 25 compounds were identified, including four xanthones, 21 steroidal saponins and eight pairs of isomers. Copyright © 2015 John Wiley & Sons, Ltd.
Engaging Employees in Sustainable Development – a Case Study of Environmental Education and Awareness Training in Hong Kong
Authors: Law Michelle Man Suet , Hills Peter , Hau Billy Chi Hang 
Published: July 2015

AbstractEnvironmental education and awareness training can help to develop and encourage a transition to a greener corporate culture. A series of environmental education and awareness training programmes of The Hongkong and Shanghai Banking Corporation Limited (HSBC) (Hong Kong) was used as a case study to assess how learning transfers through nature‐based environmental education and awareness training and to investigate the possible outcomes of providing nature‐based training to employees. Evaluation of the training outcomes, in terms of changes in employees’ environmental knowledge, attitudes and behaviour, was surveyed by using retrospective post‐ and then‐test questionnaires. Results showed that employees who joined these programmes gained knowledge and changed their values and behaviour towards the environment significantly. The study also indicated the establishment of trust in and satisfaction with the organization among employees through the training, which in turn promoted employees’ organizational commitment towards corporate sustainability. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
A Retrospective Analysis of Children's Assessment Reports: What Helps Children Tell?
Authors: McElvaney Rosaleen , Culhane Maebh 
Published: July 2015

This paper explores a retrospective analysis of children's file data as a research method of gathering information on children's experiences of informal disclosure of child sexual abuse. This study extracted data from files where children were seen for a child sexual abuse evaluation in Ireland and the children were deemed to have given a credible account of abuse by the professionals concerned. A content analysis was conducted using themes identified in previously published research, based on direct interviews with children about their experiences of informal disclosure. The paper discusses the relative merits and limitations of this method, through reporting on the findings of the file analysis and comparing these findings with findings obtained from a smaller sub‐sample of this sample of children, who were interviewed about their experiences of disclosure. It is suggested that this method is worth exploring with a larger sample size which would enable statistical analysis and thus explore the predictive factors influencing early informal disclosure. Frontline services can contribute to the knowledge base on what helps children tell through service‐based research that uses data already collected from evaluation interviews with children, thus eliminating the need to interview children for research purposes. Copyright © 2015 John Wiley & Sons, Ltd.‘A content analysis was conducted using themes identified in previously published research’Key Practitioner Messages

Frontline professionals gather useful data on a daily basis on informal disclosures of child sexual abuse.
Practitioners can contribute to the knowledge base on informal disclosure by systematically gathering information from service users.
We need more information on what helps children tell. We therefore need to explore innovative methods of gathering such information directly from children in ways that do not rely on interviewing children repeatedly yet include the child's voice.
‘We need more information on what helps children tell’
The Relationship between Maternal Childhood Emotional Abuse/Neglect and Parenting Outcomes: A Systematic Review
Authors: Hughes Mary , Cossar Jill 
Published: July 2015

This paper reviews the evidence concerning the association between reported maternal childhood experience of emotional abuse and/or neglect and subsequent parenting outcomes. Relevant studies were identified through a systematic search of four electronic databases using a pre‐determined keyword search. Reference lists of included papers were reviewed and key authors in the field contacted to ascertain whether other papers were available. Twelve studies which met our eligibility criteria were included for review. Tentative support was found for a relationship between maternal childhood emotionally abusive/neglectful experiences and a range of adverse parenting outcomes, including increased parenting stress and maltreatment potential, lower empathy and greater psychological control. However, limitations within the research (e.g. small sample sizes, retrospective designs) reduce the confidence with which we can draw firm conclusions. Recommendations are offered for future research together with an outline of clinical implications arising from this review. Copyright © 2015 John Wiley & Sons, Ltd.‘Twelve studies which met our eligibility criteria were included for review’Key Practitioner Messages

There is tentative evidence that maternal childhood experience of emotional abuse/neglect may be associated with subsequent deficits in parenting.
Maternal childhood experiences of being parented should be considered when attempting to make sense of children's difficulties and/or problems in the parent-child relationship.
Further research is required to explore these relationships and to build on our knowledge about contextual risk and protective factors.
‘Maternal childhood experiences of being parented should be considered’
Minority Identity Strategies Bound by Prejudice: Restricted Perspectives of People Categorized as Gypsies in Hungary
Authors: Bigazzi Sára , Csertő István 
Published: July 2015

AbstractIn this study, we explored the identity strategies of Hungarian Gypsies with different socialization backgrounds, including the degree of majority and minority identifications, the contents of Gypsy identity as well as coping with threatening social situations. Sampling was based on external social categorization: majority members were asked for contacts to Gypsy acquaintances. Questionnaire data were used to assess socialization background, group identification and preferred coping strategies at different levels, while contents of Gypsy identity were explored in an associative network. Results suggest that subjects make an exclusive choice between national and ethnic identities. While all subjects prefer ethnic identity, subjects with different socialization backgrounds follow different identity strategies. In sum, large‐family subjects are emotionally attached to their ethnic group, avoid interaction with the majority and prefer the idea of a multicultural society. Small‐family subjects are emotionally detached from their ethnic group and vote for a homogeneous society. Results are interpreted in terms of integration‐related social policies. While these are aimed at the foundation of a recognized active minority, members of these new generations find the way of recognition in individual assimilation due to the threat of prejudice. Copyright © 2015 John Wiley & Sons, Ltd.
Potential‐Induced Segregation Phenomena in Bimetallic PtAu Nanoparticles: An In Situ Near‐Ambient‐Pressure Photoelectron Spectroscopy Study
Authors: Papaefthimiou Vasiliki , Diebold Morgane , Ulhaq‐Bouillet Corinne , Doh Won Hui , Blume Raoul , Zafeiratos Spyridon , Savinova Elena R. 
Published: July 2015

AbstractThe surface properties of a model membrane electrode assembly of a high‐temperature proton‐exchange‐membrane fuel cell with a nanostructured PtAu working electrode were studied under operando conditions (polarization, humidified H2 atmosphere, 150 °C) using near‐ambient‐pressure photoelectron spectroscopy (NAP–XPS). NAP–XPS proved to be a powerful tool for the in situ investigation of the changes in the chemical composition, the segregation of the two metals, and the changes in their oxidation state. Nondestructive depth profiling revealed the influence of the polarization and the gas ambient on the distribution of the two metals in the near‐surface region. The results suggest that the surface of the electrode is covered by a thin layer of gold, which is stable at potentials below the onset of surface‐oxide formation. Anodic oxidation of the PtAu electrode pulls Pt to the surface, leading to intermixing of Pt and Au atoms and the formation of an interfacial alloy.