bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of routinely employed procedures for tissue processing on the proteomic analysis of formalin‐fixed paraffin‐embedded tissue
Authors: Bronsert Peter , Weißer Juliane , Biniossek Martin L. , Kuehs Markus , Mayer Bettina , Drendel Vanessa , Timme Sylvia , Shahinian Hasmik , Küsters Simon , Wellner Ulrich F. , Lassmann Silke , Werner Martin , Schilling Oliver 
Published: June 2014

PurposeFFPE (formalin fixed, paraffin embedded) tissue cohorts represent an enduring archive of clinical specimens. Proteomic analysis of FFPE tissues is gaining interest for the in‐depth analysis of aberrant proteome composition. Procedures for FFPE tissue processing are standardized but there is diversity regarding the different processing systems. This work focuses on three different processing methods commonly used in large European pathology institutes.Experimental designFormalin fixed tissue specimens of different tumors were serially sliced and processed with three different processing systems (xylene, ethanol/vacuum or microwave based). After paraffin embedding, they were subjected to MS‐based proteomic analysis to investigate the impact of tissue processing techniques on the quality of proteomic analysis. Results were compared with proteomic analysis of corresponding cryopreserved tissue specimens.ResultsAll processing techniques achieved very good proteome coverage similar to the cryopreserved counterpart. Gene ontology profiles, relative protein abundances, and peptide modifications such as methionine oxidation or proteolytic truncation were highly similar for all techniques as well as for the cryopreserved samples.Conclusions and clinical relevanceThe results show that different processing procedures do not impede proteomic analysis as a robust and powerful approach for the identification of protein determinants and markers of disease processes and highlights the general robustness of FFPE‐tissue based proteomics.
Nonassociative field theory on non‐geometric spaces
Authors: Mylonas D. , Szabo R.J. 
Published: June 2014

AbstractWe describe quasi‐Hopf twist deformations of flat closed string compactifications with non‐geometric R‐flux using a suitable cochain twist, and construct nonassociative deformations of fields and differential calculus. We report on our new findings in using this formalism to construct perturbative nonassociative field theories on these backgrounds. We describe the modifications to the usual classification of Feynman diagrams into planar and non‐planar graphs. The example of φ4 theory is studied in detail and the one‐loop contributions to the two‐point function are calculated.
Geometry and quantum noise
Authors: Barbón J.L.F. , Rabinovici E. 
Published: June 2014

AbstractWe study the fine structure of long‐time quantum noise in correlation functions of AdS/CFT systems. Under standard assumptions of quantum chaos for the dynamics and the observables, we estimate the size of exponentially small oscillations and trace them back to geometrical features of the bulk system. The noise level is highly suppressed by the amount of dynamical chaos and the amount of quantum impurity in the states. This implies that, despite their missing on the details of Poincaré recurrences, ‘virtual’ thermal AdS phases do control the overall noise amplitude even at high temperatures where the thermal ensemble is dominated by large AdS black holes. We also study EPR correlations and find that, in contrast to the behavior of large correlation peaks, their noise level is the same in TFD states and in more general highly entangled states.
Synchronization analysis for nonlinear bilateral teleoperator with interval time‐varying delay
Authors: Yang Xian , Hua Changchun , Yan Jing , Guan Xinping 
Published: June 2014

SummaryIn this paper, we investigate synchronization problem of nonlinear teleoperator in the presence of variable time delay. Compared with previous works, we relax the restriction of the communication delay range. Although approaches to the interval time delay can be found in many literatures, they are not suitable for nonlinear teleoperator due to the properties of robotic systems. We first investigate the synchronization of teleoperation system with interval time delay and make full use of the information of both the lower and upper bounds of delay. All criteria are presented in the form of LMI, which can be easily calculated by MATLAB (MathWorks, USA). Finally, numerical example and simulation are given to show the effectiveness of the main results. Copyright © 2014 John Wiley & Sons, Ltd.
Bloom‐filter based IP‐CHOCK detection scheme for denial of service attacks in VANET
Authors: Verma Karan , Hasbullah Halabi 
Published: June 2014

ABSTRACTVehicular ad hoc networks (VANETs) have drawn increasing attention in recent years due to their wide range of applications. At the present time, vehicle communication is exposed to many security threats, such as denial of service (DoS) attacks. In these attacks, a malicious node forges a large number of fake identities. Internet Protocol (IP) spoofing addresses is to disrupt the proper functioning of the fair data transfer between two fast moving vehicles. In this paper, IP spoofing addresses of DoS attacks have been detected and defended by using the Bloom‐filter based IP‐CHOCK detection method, which provides the availability of a service for the legitimate vehicles in the VANET. The IP spoofing addresses in the DoS attacks committed by fraud and malicious nodes have also been investigated. This method provides a secure communication as well as frees the bandwidth. This proposed approach requires fewer resources and is easy to deploy. Simulation results have shown that this method is efficient and effective to detect and defend against DoS attacks in the VANET. Specifically, this method provides faster detection time, lower storage capacity, and computational cost. Copyright © 2014 John Wiley & Sons, Ltd.
Maternal venous Doppler characteristics are abnormal in pre‐eclampsia but not in gestational hypertension
Authors: Gyselaers W. , Staelens A. , Mesens T. , Tomsin K. , Oben J. , Vonck S. , Verresen L. , Molenberghs G. 
Published: June 2014

ABSTRACTObjectiveTo compare functional characteristics of maternal thoraco‐abdominal arteries and veins in proteinuric and non‐proteinuric hypertension in pregnancy.MethodsThis retrospective study included women with singleton pregnancies during the third trimester, which were either uncomplicated or complicated with different clinical types of hypertension: non‐proteinuric gestational hypertension (GH), early‐onset pre‐eclampsia (PE) diagnosed < 34 weeks or late‐onset PE diagnosed ≥ 34 weeks. Demographic maternal and neonatal data were recorded, together with maternal serum and urine analytes. All women underwent standardized automated blood‐pressure measurement, together with non‐invasive impedance cardiography (ICG), for measurement of cardiac output (CO), aortic flow velocity index (VI) and aortic flow acceleration index (ACI). A standardized combined Doppler–electrocardiography assessment of maternal venous hemodynamics was performed to measure renal interlobar vein impedance index (RIVI), hepatic vein impedance index (HVI) and venous pulse transit time (VPTT) in liver and kidneys. Finally, resistance index (RI), pulsatility index (PI) and arterial pulse transit time (APTT) were measured in the uterine arcuate arteries. Mann–Whitney U‐tests and Fisher's exact tests were used for intergroup comparisons, and linear dependence between variables was assessed using Pearson's correlation coefficient (r).ResultsA total of 150 pregnancies were evaluated: 22 with uncomplicated pregnancy, 41 GH, 31 early PE and 56 late PE. Aortic VI and ACI were lower in GH, early PE and late PE than in uncomplicated pregnancy. Both early PE and late PE differed from GH by having shorter APTT in the uterine arcuate arteries and higher RIVI. Hemodynamic abnormalities were most pronounced in early PE, during which uterine arcuate artery RI was higher and VPTT in kidneys was shorter than in late PE. There was a significant correlation between degree of proteinuria and RIVI for the left
(r = 0.381) and right (r = 0.347) kidney in late PE, but this was not true for early PE.ConclusionsThere is a gradient of worsening arterial and venous hemodynamic abnormalities from GH to late PE and then to early PE. Venous hemodynamic abnormalities are present only in PE, with a linear correlation between proteinuria and RIVI in late PE. The role of the maternal venous compartment in the pathophysiology and etiology of PE‐related symptoms may be much more important than considered at present. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.
Percutaneous minimally invasive fetoscopic surgery for spina bifida aperta. Part I: surgical technique and perioperative outcome
Authors: Kohl T. 
Published: June 2014

ABSTRACTObjectivesTo analyze the current technical approach of percutaneous minimal‐access fetoscopic closure of spina bifida aperta (SBA) and provide an overview of its development in ovine and human fetuses.MethodsMinimal‐access percutaneous fetoscopic closure of SBA was performed at the German Center for Fetal Surgery & Minimal‐access Therapy (DZFT) in 51 human fetuses at 21.0–29.1 weeks of gestation (mean age, 23.7 weeks). Various parameters of surgical relevance for the success and safety of the procedure and the early perioperative outcome were analyzed retrospectively. In addition, information from the early clinical cases was examined to determine how this shaped development of the approach.ResultsPercutaneous minimal‐access fetoscopic closure of SBA was performed with a high rate of technical success, regardless of placental or fetal position. All fetuses survived surgery, but there was one very early preterm delivery 1 week after the procedure and this neonate died immediately, from early postoperative chorioamnionitis. Of the 50 surviving fetuses, 44 (88%) were delivered at or beyond 30 weeks and 25 (50%) at or beyond 34 weeks of gestation. There was one neonatal death from an uinsuspected case of trisomy 13 and two infant deaths from Chiari‐II malformation.ConclusionsFollowing an adequate learning curve, minimal‐access fetoscopic surgery for fetal spina bifida can be performed with a high rate of technical success, regardless of placental position. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.
Revisión de instrumentos de evaluación de clima organizacional
Authors: Cardona Echeverri Diego Raúl , Zambrano Cruz Renato 
Published: June 2014

Este artículo presenta una caracterización de diferentes instrumentos de evaluación del clima organizacional. Para este fin se realizó un estudio de revisión sistemática de la literatura de publicaciones en los últimos 15 años en donde se encontraron 10 artículos que presentaban instrumentos de evaluación de clima organizacional. De estos artículos se realizó un análisis de las propiedades psicométricas y de las dimensiones evaluadas. Se halló que existe un grupo de 8 dimensiones que se repiten en la mayoría de los instrumentos: toma de decisiones, claridad organizacional, liderazgo, interacción social, motivación institucional, sistema de recompensas e incentivos, apertura organizacional y supervisión.
Serotonin dynamics in and around the central nervous system: Is autism solvable without fundamental insights?
Authors: Janušonis Skirmantas 
Published: June 2014

AbstractAltered serotonin (5‐hydroxytryptamine, 5‐HT) signaling has been implicated in some developmental abnormalities of autism spectrum disorder (ASD). However, the presumed role of 5‐HT in ASD raises new questions in fundamental neuroscience. Specifically, it is not clear if the current piecemeal approach to 5‐HT signaling in the mammalian body is effective and whether new conceptual approaches may be required. This review briefly discusses 5‐HT production and circulation in the central nervous system and outside of it, especially with regard to ASD, and proposes a more encompassing approach that questions the utility of the “neurotransmitter” concept. It then introduces the idea of a generalized 5‐HT packet that may offer insights into possible links between serotonergic varicosities and blood platelets. These approaches have theoretical significance, but they are also well positioned to advance our understanding of some long‐standing problems in autism research.
Geochemical interaction between the freshwater and marine hydrospheres
Authors: Gordeev V.V. , Lisitzin A.P. 
Published: June 2014

Abstract
The results of more than 40 years long authors’ investigations in the field of the freshwater (river input) and marine (ocean waters) hydrospheres are summarized. The latest estimations of the global average concentrations of many chemical elements in river water and suspended matter and in ocean water and suspended matter are presented. It is shown that particulate suspended forms of many elements are predominant in river waters (“rivers are the kingdom of suspended forms of elements”), while their dissolved forms prevail in ocean waters (“ocean is the kingdom of dissolved forms of elements”). Sedimentary and biogeochemical processes of the river material transformation in the river–sea mixing zone (the so-called “marginal filter of the ocean”) were studied thoroughly. It was shown that radical quantitative and qualitative changes of dissolved and particulate suspended substances take place in this zone, resulting in the governed transformation of dissolved forms into suspended particulate forms and their following deposition on the bottom. The first data on the losses of 35 chemical elements in the river–sea mixing zone are presented. These data prove that the concentrations of dissolved elements in river and ocean waters are in regular and close relationship with their losses in the river–sea mixing zone and with the types of element distribution in ocean water column (conservative, biogenic, and lithogenic). This indicates the existence of a geochemical system in the entire (freshwater and marine) hydrosphere, which calls for deep and detailed investigations.
Cretaceous paleogeography of the West Siberian sedimentary basin
Authors: Kontorovich A.E. , Ershov S.V. , Kazanenkov V.A. , Karogodin Yu.N. , Kontorovich V.A. , Lebedeva N.K. , Nikitenko B.L. , Popova N.I. , Shurygin B.N. 
Published: June 2014

Abstract
For paleogeographic reconstruction of the West Siberian basin during the Cretaceous we used a set of paleogeographic maps, which were compiled for the main epochs of the Cretaceous period. The paleogeographic maps presented in this study suggest progradational filling of the deep basin with avalanche-type sedimentation during Volgian–Barremian regression. The paleorelief and provenance of terrigenous sediments were reconstructed.
Sedimentology and isotope geochemistry of Riphean carbonates in the Kharaulakh Range of northern East Siberia
Authors: Khabarov E.M. , Izokh O.P. 
Published: June 2014

Abstract
Stable carbon isotope variations in primarily offshore Proterozoic carbonates of the Eselekh, Neleger, and Sietachan Formations in the Kharaulakh Range of northern East Siberia provide important information on the depositional history of the Riphean complexes and allow an age estimate to be made for potentially petroliferous Precambrian strata in the northeast of the Siberian Platform. The results of petrographic, geochemical, and isotopic studies of the measured samples demonstrate that the carbonates are recrystallized without substantial postdepositional alteration of the carbon isotope system and that the acquired δ13C values are accurate and can be used for the purposes of chemostratigraphy. The Riphean strata of the Kharaulakh Range are characterized by mostly high (5.5–8.6‰c) δ13C values. Based on carbon isotope data, the studied section could not be correlated with Mesoproterozoic strata of the Anabar and Olenek Uplifts but occupies a rather higher stratigraphic position. It can be correlated with the Baikal Group of the West Pre-Baikal Area and the Dal’nyaya Taiga Group of the Patom Upland; specifically, the negative shift in the uppermost Sietachan Formation possibly corresponds to the Zhuya negative excursion. Comparison with the model curve of carbon isotope evolution in the Precambrian ocean suggests that the age of the studied section does not exceed 820 Ma. Most likely, the studied strata are younger than 635 Ma (i.e., postdate the Marino glaciation) but older than the Gaskiers glaciation (580 Ma).
The effect of Meso-Cenozoic tectonic processes on the formation of Upper Jurassic and Cretaceous hydrocarbon pools in the north of the Aleksandrov arch (West Siberia)
Authors: Kontorovich V.A. , Kalinin A.Yu. , Kalinina L.M. , Solov’ev M.V. 
Published: June 2014

Abstract
The effect of tectonic processes on the petroleum potential of the Upper Jurassic and Cretaceous sediments is estimated by the example of the deposits in the north of the Aleksandrov arch. The formation history of the structures bearing Upper Jurassic and Cretaceous hydrocarbon (HC) pools is discussed.
The results obtained lead to the conclusion that anticlinal traps complicated by faults cutting the Meso-Cenozoic sedimentary cover are the most promising for the formation of large HC pools in Cretaceous sand reservoirs. These traps serve as channels for HC migration from the oil-producing rocks of the Bazhenovo Formation into the overlying reservoirs. In the Upper Jurassic sediments, anticlinal traps free from Cenozoic faults are the most promising for HC accumulation. These conclusions are confirmed by a number of examples.
Repeated sinomenine administration alleviates chronic neuropathic pain-like behaviours in rodents without producing tolerance
Authors: Gao Tianle , Shi Tiansheng , Wang Dan-Qiao , Wiesenfeld-Hallin Zsuzsanna , Xu Xiao-Jun 
Published: June 2014

Abstract

Background and aims
We have previously reported that systemic administration of sinomenine produced antinociception in various experimental pain conditions in rodents, particularly in models of neuropathic pain. In the present study we assessed the effects of repeated administration of sinomenine in two rodent models of neuropathic pain in order to study the development of tolerance.

Methods
The analgesic effect of sinomenine was tested in female Sprague-Dawley rats that exhibited mechanical and cold hypersensitivity following ischaemic injury to the spinal cord and in male C57/BL6 mice that developed mechanical hypersensitivity after ischaemic injury to the sciatic nerve. Briefly, the animals were anaesthetized and injected i.v. with the photosensitizing dye erythrosine B. Vertebral segments T12 to T13 in rats or the sciatic nerve in mice were exposed and irradiated under an argon ion laser for 10min or 45s, respectively. In rats, mechanical hypersensitivity to pressure with von Frey hairs, the response to brushing and decreasing cold temperature were tested in the flanks or upper back areas. In mice, mechanical hypersensitivity on the hind paw to von Frey hairs and response to cold following a drop of acetone were measured. Sinomenine was administered i.p. in rats and p.o. in mice at 10:00 and 16:00, twice a day for 5 days. Response threshold before and 2h after drug administration at 10.00h was recorded.

Results
Repeated administration of sinomenine at 10 or 20mg/kg twice a day, doses that have no analgesic effect as single injection, alleviated mechanical, but not cold allodynia in spinally injured rats and the effect was maintained during the 5 day treatment period with no signs of tolerance. Furthermore, the pre-drug response threshold was significantly elevated during repeated treatment with 20mg/kg sinomenine. Sinomenine administered at 40mg/kg twice a day for 5 days significantly reduced mechanical and cold alldoynia, elevated pre-drug response threshold without tolerance development in spinally injured rats. Similarly, sinomenine at 80mg/kg twice a day for 5 days significantly reduced mechanical allodynia in mice with sciatic nerve injury and increased pre-drug response threshold with no sign of tolerance. The effect of sinomenine on response threshold persisted for days after termination of the 5 day drug administration.

Conclusions
The results suggest that repeated administration of simomenine produced an enhanced anti-allodynic effect without tolerance in rodent models of neuropathic pain.

Implications
Sinomenine may be tested as a novel analgesic in treating some forms of chronic neuropathic pain in patients.
Preclinical and clinical research on bone and cartilage regenerative medicine in oral and maxillofacial region
Authors: Takato Tsuyoshi , Mori Yoshiyuki , Fujihara Yuko , Asawa Yukiyo , Nishizawa Satoru , Kanazawa Sanshiro , Ogasawara Toru , Saijo Hideto , Abe Takahiro , Abe Masanobu , Suenaga Hideyuki , Kanno Yuki , Sugiyama Madoka , Hoshi Kazuto 
Published: June 2014

AbstractRecently, there have been remarkable advances in regenerative medicine, and almost all disorders of the oral and maxillofacial region could be research targets of regenerative medicine. Meanwhile, treatment in this region has been well established using biomaterials, prostheses, and microsurgery. Therefore, to surpass such a conventional approach as an alternative, regenerative medicine should take an approach of being less invasive and/or more effective. In this report, we present our preclinical and clinical research on bone and cartilage regenerative medicine in the oral and maxillofacial region.Regarding bone regenerative medicine, we have tried to develop artificial bone that would maximize bone formation at the transplanted site, but would subsequently be replaced by autologous bone. We have made custom‐made artificial bone (CT‐Bone) using alpha‐tricalcium phosphate (α‐TCP) particles and an ink‐jet printer, and have conducted clinical research and trials on 30 patients.To develop tissue‐engineered cartilage with proper three‐dimensional (3D) morphological form and mechanical strength, we have optimized the culture medium of chondrocytes and the scaffold. Following a preclinical study confirming efficacy and safety, we have conducted clinical research in three patients with nasal deformity associated with cleft lip and palate, and are now starting multicenter clinical research.
The Economy of the Temples of God in the Turmoil of Changing Russia
Authors: Tocheva Detelina 
Published: June 2014

AbstractThe liberalisation of religious practice after the fall of the Soviet regime and the support by the Russian state to the Russian Orthodox Church have contributed to the enormous growth of the church economy. Controversies within and without the Church interrogate commercial and gifting practices. The relationship between the expansion of church commerce and the operation of moral boundaries, underlined by critical stances, has been determined by culture and history, with the post-Soviet transformation having played a key role in shaping popular notions of selflessness and profit-seeking. Moreover, as people participate in the church economy they mobilise perceptions of the differential moral valence of gift and commerce in order to communicate concerning the power of the Church, its controversial image, Russia’s social stratification, and to deploy ethics of equity and honesty.