bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the Productive Ward at an acute NHS trust: experiences and implications of releasing time to care
Authors: Wright Stella , McSherry Wilfred 
Published: December 2013

Aims and objectivesTo demonstrate how a national programme aimed to increase the amount of direct time nurses spend with patients', impacts on both staff and patient experience.BackgroundThe Productive Ward is an improvement programme developed by the NHS Institute for Innovation and Improvement (2007, http://www.institute.nhs.uk/quality_and_value/productivity_series/productive_ward.html) which aims to enable nurses to work more efficiently by reviewing process and practice, thus releasing more time to spend on direct patient care. However, there is little empirical published research around the programme, particularly concerning impact, sustainability and the patient perspective.DesignThis manuscript presents the findings from qualitative interviews involving both staff and patients.MethodsSemi‐structured one‐to‐one interviews were conducted with patients (n = 8) and staff (n = 5) on five case study wards. Seven focus groups were held according to staff grade (n = 29).ResultsDespite initial scepticism, most staff embraced the opportunity and demonstrated genuine enthusiasm and energy for the programme. Patients were generally complimentary about their experience as an inpatient, reporting that staff made them feel safe, comfortable and cared for.ConclusionFindings showed that the aims of the programme were partially met. The implementation of Productive Ward was associated with significant changes to the ward environment and improvements for staff. The programme equipped staff with skills and knowledge which acted as a primer for subsequent interventions. However, there was a lack of evidence to demonstrate that Productive Ward released time for direct patient care in all areas that implemented the programme.Relevance to clinical practiceDeveloping robust performance indicators including a system to capture reinvestment of direct care time would enable frontline staff to demonstrate impact of the programme. Additionally, staff will need to ensure that reorganisation and instability across the NHS do not affect sustainability and viability of the Productive Ward in the long term.
Health-Related Quality of Life in Patients with Polycystic Ovary Syndrome (PCOS): A Model-Based Study of Predictive Factors
Authors: Bazarganipour Fatemeh , Ziaei Saeide , Montazeri Ali , Foroozanfard Fatemeh , Kazemnejad Anoshirvan , Faghihzadeh Soghrat 
Published: December 2013

Abstract

Introduction
Understanding the factors that contribute to health-related quality of life (HRQOL) is critical for developing the most appropriate interventions for improving or maintaining the HRQOL in polycystic ovary syndrome (PCOS) patients.

Aim
This study sought to determine the most significant predictors of the HRQOL in patients with PCOS.

Methods
This was a cross-sectional study of 300 women with PCOS that was carried out in Kashan, Iran. A sample of women with PCOS was entered into the study and completed the following questionnaires: the Hospital Anxiety and Depression Scale, the Body Image Concern Inventory (BICI), the Rosenberg's Self-Esteem Scale score, the modified polycystic ovary syndrome health-related quality of life questionnaire, the Female Sexual Function Index.

Main Outcome Measure
Both direct and indirect relationships among clinical severity, psychological status, self-esteem, body image, and sexual function as independent predictors of HRQOL were examined using structural equation modeling (SEM) analysis. By using the SEM, we simultaneously test a number of possible hypotheses concerning the interrelations among the predictors of HRQOL in PCOS patients.

Results
In relation with severity of PCOS, reproductive history and menstrual status explained a high proportion of the variance of clinical variables (factor loading 0.37 and 0.34, respectively). The highest effect on HRQL was exerted by indirect effect of clinical factor (β = 0.90), self-esteem (β = 1.12), body image (β = 1.06), and sexual function (β = 0.26) that influenced negatively HRQOL. The infertility and menstrual domains were the most affected areas of HRQOL. In relation with sexual dysfunction, the most affected domains were desire and arousal.

Conclusion
The highest effect of PCOS symptoms on HRQOL impairment among patients was exerted by self-esteem, body image, and sexual dysfunction. With regard to HRQOL in clinical routine, we conclude these mediating factors should be taken into consideration and adequately treated if present.
Libyan Desert Glass: New field and Fourier transform infrared data
Authors: Fröhlich F. , Poupeau G. , Badou A. , Le Bourdonnec F. X. , Sacquin Y. , Dubernet S. , Bardintzeff J. M. , Véran M. , Smith D. C. , Diemer E. 
Published: December 2013

AbstractResults are presented of new geological observations and laboratory analyses on Libyan Desert Glass (LDG), a unique kind of impact glass found in Egypt, probably 28.5–29.4 million years in age. A new LDG occurrence has been discovered some 50 km southward of the main LDG occurrences in the Great Sand Sea. From Fourier transform infrared (FTIR) analysis, the molecular structure of LDG is refined and significant differences are shown between LDG specimens and other pure silica glasses (fulgurite, industrial fused quartz, and amorphous biogenic silica) that are related to differences in their structures. The slight variations observed here for the mean Si‐O‐Si angle between the different glasses are attributed to their thermal histories. With regard to the other glasses analyzed, the LDG infrared spectral parameters point to a higher ratio of discontinuities and defects in the tetrahedral (SiO4) network. The quantitative mineralogical constitutions of sandstones and quartzites from the LDG geological setting were analyzed by FTIR. Cretaceous sandstones have a specific composition (about 90 wt% quartz, 10% dickite), clearly different from the Paleozoic ones (about 90 wt% quartz, but ≥7% kaolinite). It is shown that the reddish silts bearing the LDG are constituted mainly of microquartz enriched with dickite, whose particle size distribution is characteristic of fluvio‐lacustrine deposits, probably Oligocene to Miocene in age. The target rocks, most probably quartz sand, resulted from the weathering (loss of the cementing microquartz) of the Cretaceous sandstones from the Gilf Khebir Plateau with deposition in a high‐energy environment.
The extremely reduced silicate‐bearing iron meteorite Northwest Africa 6583: Implications on the variety of the impact melt rocks of the IAB‐complex parent body
Authors: Fazio Agnese , D'Orazio Massimo , Folco Luigi , Gattacceca Jérôme , Sonzogni Corinne 
Published: December 2013

AbstractNorthwest Africa (NWA) 6583 is a silicate‐bearing iron meteorite with Ni = 18 wt%. The oxygen isotope composition of the silicates (∆′17O = −0.439 ‰) indicates a genetic link with the IAB‐complex. Other chemical, mineralogical, and textural features of NWA 6583 are consistent with classification as a new member of the IAB‐complex. However, some unique features, e.g., the low Au content (1.13 μg g−1) and the extremely reducing conditions of formation (approximately −3.5 ∆IW), distinguish NWA 6583 from the known IAB‐complex irons and extend the properties of this group of meteorites. The chemical and textural features of NWA 6583 can be ascribed to a genesis by impact melting on a parent body of chondritic composition. This model is also consistent with one of the most recent models for the genesis of the IAB‐complex. Northwest Africa 6583 provides a further example of the wide lithological and mineralogical variety that impact melting could produce on the surface of a single asteroid, especially if characterized by an important compositional heterogeneity in space and time like a regolith.
Promiscuity resolves constraints on social mate choice imposed by population viscosity
Authors: While Geoffrey M. , Uller Tobias , Bordogna Genevieve , Wapstra Erik 
Published: December 2013

AbstractPopulation viscosity can have major consequences for adaptive evolution, in particular for phenotypes involved in social interactions. For example, population viscosity increases the probability of mating with close kin, resulting in selection for mechanisms that circumvent the potential negative consequences of inbreeding. Female promiscuity is often suggested to be one such mechanism. However, whether avoidance of genetically similar partners is a major selective force shaping patterns of promiscuity remains poorly supported by empirical data. Here, we show (i) that fine‐scale genetic structure constrains social mate choice in a pair‐bonding lizard, resulting in individuals pairing with genetically similar individuals, (ii) that these constraints are circumvented by multiple mating with less related individuals and (iii) that this results in increased heterozygosity of offspring. Despite this, we did not detect any significant effects of heterozygosity on offspring or adult fitness or a strong relationship between pair relatedness and female multiple mating. We discuss these results within the context of incorporating the genetic context dependence of mating strategies into a holistic understanding of mating system evolution.
Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid‐like fatty acid amides
Authors: Fichna J. , Sałaga M. , Stuart J. , Saur D. , Sobczak M. , Zatorski H. , Timmermans J. ‐P. , Bradshaw H. B. , Ahn K. , Storr M. A. 
Published: December 2013

AbstractBackgroundThe endogenous cannabinoid system (ECS) plays a crucial role in multiple physiological processes in the central nervous system and in the periphery. The discovery that selective cannabinoid (CB) receptor agonists exert a potent inhibitory action on gastrointestinal (GI) motility and pain has placed the ECS in the center of attention as a possible target for the treatment of functional GI diseases. However, side effects of CB agonists prompted the search for novel therapeutic targets. Here, the effect of PF‐3845, a potent and selective fatty acid amide hydrolase (FAAH) inhibitor in the GI tract was investigated.MethodsThe effect of PF‐3845 on GI motility was characterized in vitro and in vivo, using mouse models that mimic physiological and pathophysiological conditions. The antinociceptive action of PF‐3845 was evaluated on the basis of behavioral pain models. Endocannabinoid degradation product levels after inhibition of FAAH were quantified using HPLC‐MS/MS.Key ResultsPF‐3845 significantly inhibited mouse colonic motility in vitro and in vivo. Selective inhibition of FAAH reversed hypermotility and reduced pain in mouse models mimicking functional GI disorders. The effects of PF‐3845 were mediated by endogenous CBs and non‐CB lipophilic compounds via classical (CB1) and atypical CB receptors.Conclusions & InferencesThese data expand our understanding of the ECS function and provide a novel framework for the development of future potential treatments of functional GI disorders.
Effectiveness of a Multimodal Treatment Program for Somatoform Pain Disorder
Authors: Pieh Christoph , Neumeier Susanne , Loew Thomas , Altmeppen Jürgen , Angerer Michael , Busch Volker , Lahmann Claas 
Published: December 2013

AbstractChronic pain conditions are highly prevalent, with somatoform pain disorder accounting for a large proportion. However, the psychological forms of treatment currently used achieve only small to medium effect sizes. This retrospective study investigated the effectiveness of a 5‐week multimodal pain program for patients with somatoform pain disorder. The diagnosis of somatoform pain disorder was confirmed by a specialist for anesthesiology and pain management and a specialist for psychosomatic medicine. Therapy outcome was evaluated with a Numeric Rating Scale (NRS), the Pain Disability Index (PDI), and the Pain Perception Scale. Within the study sample (n = 100), all parameters showed a significant and clinically relevant improvement at the end of therapy (P values < 0.001). The highest effect sizes (d) were found for reduction in average pain rating (NRS: d = 1.00) and the affective items of the Pain Perception Scale (SES‐A: d = 0.07). The lowest effect sizes were found for improvement of pain‐related disabilities (PDI: d = 0.42) and sensory items of the Pain Perception Scale (SES‐S: d = 0.50). Despite high chronification of pain condition, with average pain duration of greater than 8 years, the multimodal treatment program showed medium to large effect sizes on the outcome of patients with somatoform pain disorder. Compared with previous data with small to moderate effect sizes, a multimodal program seems to be more effective than other interventions to address somatoform pain disorder.
Thrombocytopenia absent radius (TAR) syndrome: a case report and review for oral health care providers
Authors: Idahosa Chizobam , Berardi Thomas R. , Shkolnikov Rosalyn , Stoopler Eric T. 
Published: December 2013

ABSTRACTThrombocytopenia Absent Radius (TAR) syndrome is a rare genetic disorder characterized by thrombocytopenia and bilateral absence of radii with both thumbs present. Multiple organ systems may be affected in patients with TAR syndrome, including hematologic, skeletal, cardiovascular, and gastrointestinal systems. This article describes a 35‐year‐old Caucasian male with TAR syndrome receiving comprehensive dental care and reviews the pertinent aspects of this disease, as well as dental management considerations, for patients with TAR syndrome.
Comprehensive transcriptome profiling of squamous cell carcinoma of horn in Bos indicus
Authors: Koringa P. G. , Jakhesara S. J. , Bhatt V. D. , Meshram C. P. , Patel A. K. , Fefar D. T. , Joshi C. G. 
Published: December 2013

AbstractSquamous cell carcinoma (SCC) of horn is frequently observed in Bos indicus affecting 1% of cattle population and accounting 83.34% of total tumours found. The transcriptome profile of horn cancer (HC) tissue and the matched normal (HN) tissue were analysed by RNA‐seq using Roche 454 sequencing. A total of 1 504 900 reads comprising of 612 MB data were used to identify differentially expressed genes using CLC Genomic Workbench. These include up‐regulation of KRT6A, KRT6B, KRT6C, KRT14, SFN, KRT84, PI3, COL17A1, ANLN, SERPINB5 and down‐regulation of BOLA, SCGB1A1, CXCL17, KRT19, BPIFB1, NR4A1 and TFF3 in HC, which are involved in regulation of gene transcription, cell proliferation, apoptosis, cell survival and metabolic pathways. The qPCR analysis of several targets suggested concordance of gene expression profile with RNA‐seq analysis. The present findings would provide basis for further screening of genes and identification of markers for early diagnosis and therapeutic intervention of HC.
Spontaneous pneumothorax associated withAspergillusbronchopneumonia in a dog
Authors: Trempala Cheryl L. , Herold Lee V. 
Published: December 2013

AbstractObjectiveTo describe a case of pulmonary aspergillosis in a previously healthy dog that manifested as a spontaneous pneumothorax.Case SummaryA 3‐year‐old neutered male mixed‐breed dog was presented with inappetence and respiratory distress. Thoracic radiography revealed a right‐sided pneumothorax. Following stabilization, thoracic computed tomography found 1 large and many small pulmonary blebs in the right caudal lung lobe. The dog underwent a right lateral thoracotomy, identifying numerous emphysematous regions in the right middle lung lobe, and a right middle lung lobectomy was performed. Histopathologic examination of the resected lung lobe revealed severe, diffuse bronchopneumonia with necrotizing pleuritis and the presence of fungal organisms strongly suggestive ofAspergillussp. Surgical removal of the affected lung lobe and continued medical treatment with itraconazole resolved the dog's clinical signs.New Information ProvidedThis report describes the successful surgical and medical management ofAspergillusbronchopneumonia in a dog presenting with spontaneous pneumothorax.
Complete Genome of Acinetobacter baumannii N4-Like Podophage Presley
Authors: Farmer Nicholas G. , Wood Thammajun L. , Chamakura Karthik R. , Kuty Everett Gabriel F. 
Published: December 2013

ABSTRACT

Acinetobacter baumannii
is an emerging multidrug-resistant nosocomial pathogen. Bacteriophages may be useful as an alternative method of treatment against this and other multidrug-resistant bacteria. Here, we present the complete genome sequence of
A. baumannii
phage Presley, an N4-like podophage.
Complete Genome of Bacillus pumilus Siphophage Glittering
Authors: Matthew Solomon P. , Decker Skyelar L. , Chamakura Karthik R. , Kuty Everett Gabriel F. 
Published: December 2013

ABSTRACT

Bacillus pumilus
is a Gram-positive bacterium widely used in agriculture both as an antifungal and as a growth-promoting symbiont.
B. pumilus
is rarely infectious but has recently been shown to infect humans. Here, we present the complete genome of
B. pumilus
phage Glittering, a potential biocontrol agent for
B. pumilus
.
Complete Genome of Bacillus subtilis Myophage Grass
Authors: Miller Stanton Y. , Colquhoun Jennifer M. , Perl Abbey L. , Chamakura Karthik R. , Kuty Everett Gabriel F. 
Published: December 2013

ABSTRACT

Bacillus subtilis
is a ubiquitous Gram-positive model organism. Here, we describe the complete genome of
B. subtilus
myophage Grass. Aside from genes encoding core proteins pertinent to the life cycle of the phage, Grass has several interesting features, including an FtsK/SpoIIIE protein.
Complete Genome of Bacillus thuringiensis Myophage Spock
Authors: Maroun Justin W. , Whitcher Kelvin J. , Chamakura Karthik R. , Kuty Everett Gabriel F. 
Published: December 2013

ABSTRACT

Bacillus thuringiensis
is a Gram-positive, sporulating soil microbe with valuable pesticide-producing properties. The study of bacteriophages of
B. thuringiensis
could provide new biotechnological tools for the use of this bacterium. Here, we present the complete annotated genome of Spock, a myophage of
B. thuringiensis
, and describe its features.
Complete Genome of Bacillus megaterium Siphophage Staley
Authors: Hastings Waylon J. , Ritter Matthew A. , Chamakura Karthik R. , Kuty Everett Gabriel F. 
Published: December 2013

ABSTRACT

Siphophage Staley was isolated because of its ability to grow on
Bacillus megaterium
. Here we report the complete genome and annotation of phage Staley and describe core features. Among its interesting genes is one encoding an SleB germination protein.
Draft Genome Sequence of Plant Growth-Promoting Rhizobacterium
Pantoea
sp. Strain AS-PWVM4
Authors: Khatri Indu , Kaur Sukhvir , Devi Usha , Kumar Navinder , Sharma Deepak , Subramanian Srikrishna , Saini Adesh K. 
Published: December 2013

ABSTRACT

Nonpathogenic
Pantoea
spp. have been shown to confer biofertilizer and biocontrol activities, indicating their potential for increasing crop yield. Herein, we provide the high-quality genome sequence of
Pantoea
sp. strain AS-PWVM4, a Gram-negative motile plant growth-promoting rhizobacterium isolated from a pomegranate plant. The 4.9-Mb genome contains genes related to plant growth promotion and the synthesis of siderophores.
Genome Sequences of Two Enterobacter pulveris Strains, 601/05
T
(=LMG 24057
T
=DSM 19144
T
) and 1160/04 (=LMG 24058 =DSM 19146), Isolated from Fruit Powder
Authors: Gopinath Gopal R. , Grim Christopher J. , Tall Ben D. , Mammel Mark K. , Sathyamoorthy Venugopal , Trach Larisa H. , Chase Hannah R. , Fanning Séamus , Stephan Roger 
Published: December 2013

ABSTRACT

We report the draft genome sequences of the
Enterobacter pulveris
strains 601/05
T
(=LMG24057
T
=DSM19144
T
) and 1160/04 (=LMG24058 =DSM19146), isolated from fruit powder. The genome assemblies for the
E. pulveris
type strain, LMG24057, and strain LMG24058 have sizes of 4,708,624 and 4,811,103 bp and G+C contents of 56.6% and 56.5%, respectively.
Genome Sequence of Parvimonas micra Strain A293, Isolated from an Abdominal Abscess from a Patient in the United Kingdom
Authors: Ang Mia Yang , Dymock David , Tan Joon Liang , Thong Ming Hang , Tan Qin Kai , Wong Guat Jah , Paterson Ian C. , Choo Siew Woh 
Published: December 2013

ABSTRACT

Parvimonas micra
is an important oral microbe that has the ability to grow and proliferate within oral biofilms and is involved in periodontal disease, leading to gingival bleeding, gingival recession, alveolar bone loss, and tooth mobility. However, occasionally these normally oral pathogens can cause infections at other sites in the body. We present the genome sequence of
Parvimonas micra
strain A293, a smooth
Parvimonas micra
strain isolated from an abdominal abscess from a patient at Barts Hospital, London, United Kingdom.
The N-Terminal Membrane-Spanning Domain of the Escherichia coli DNA Translocase FtsK Hexamerizes at Midcell
Authors: Bisicchia Paola , Steel Bradley , Mariam Debela Mekdes H. , Löwe Jan , Sherratt David 
Published: December 2013

ABSTRACT

Bacterial FtsK plays a key role in coordinating cell division with the late stages of chromosome segregation. The N-terminal membrane-spanning domain of FtsK is required for cell division, whereas the C-terminal domain is a fast double-stranded DNA (dsDNA) translocase that brings the replication termination region of the chromosome to midcell, where it facilitates chromosome unlinking by activating XerCD-
dif
site-specific recombination. Therefore, FtsK coordinates the late stages of chromosome segregation with cell division. Although the translocase is known to act as a hexamer on DNA, it is unknown when and how hexamers form, as is the number of FtsK molecules in the cell and within the divisome. Using single-molecule live-cell imaging, we show that newborn
Escherichia coli
cells growing in minimal medium contain ~40 membrane-bound FtsK molecules that are largely monomeric; the numbers increase proportionately with cell growth. After recruitment to the midcell, FtsK is present only as hexamers. Hexamers are observed in all cells and form before any visible sign of cell constriction. An average of 7 FtsK hexamers per cell are present at midcell, with the N-terminal domain being able to hexamerize independently of the translocase. Detergent-solubilized and purified FtsK N-terminal domains readily form hexamers, as determined by
in vitro
biochemistry, thereby supporting the
in vivo
data. The hexameric state of the FtsK N-terminal domain at the division site may facilitate assembly of a functional C-terminal DNA translocase on chromosomal DNA.

IMPORTANCE
In the rod-shaped bacterium
Escherichia coli
, more than a dozen proteins act at the cell center to mediate cell division, which initiates while chromosome replication and segregation are under way. The protein FtsK coordinates cell division with the late stages of chromosome segregation. The N-terminal part of FtsK is membrane embedded and acts in division, while the C-terminal part forms a hexameric ring on chromosomal DNA, which the DNA can translocate rapidly to finalize chromosome segregation. Using quantitative live-cell imaging, which measures the position and number of FtsK molecules, we show that in all cells, FtsK hexamers form only at the cell center at the initiation of cell division. Furthermore, the FtsK N-terminal portion forms hexamers independently of the C-terminal translocase.