bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thinness in the Pursuit for Social Safeness: An Integrative Model of Social Rank Mentality to Explain Eating Psychopathology
Authors: Pinto‐Gouveia José , Ferreira Cláudia , Duarte Cristiana 
Published: October 2012

The current study tests a model based on social rank mentality investigating whether women who feel inferior and believe others see them negatively, and feel under pressure to compete to avoid social inferiority, present increased body dissatisfaction and drive for thinness and whether these associations are mediated by distinct emotional regulation processes. The predictions from the model proposed were examined through path analyses, in a sample of 125 women from the general population and 102 patients with eating disorders.Results showed that the path model explained 51% of body dissatisfaction variance and 61% of drive for thinness and allowed us to confirm that social ranking variables increased drive for thinness through higher levels of self‐criticism and lower levels of self‐compassion.The findings suggest that the nuclear eating disorders' features arise as a result of a more self‐critical and less compassionate attitude with the self, in the context of a mentality focused on social ranking and competition. Copyright © 2012 John Wiley & Sons, Ltd.Key Practitioner MessageThe current study explores an innovative comprehensive model based on social rank theory to understand eating disorders' symptoms in women.A mentality focused on ranking, shame and competition predicts body image dissatisfaction.This ranking‐focused mentality, along with body image dissatisfaction, leads to drive for thinness through increased self‐criticism and decreased self‐compassion.These findings support the emergent psychotherapeutic approaches for eating disorders that target self‐criticism and self‐compassion.
Stability of T cell phenotype and functional assays following heparinized umbilical cord blood collection
Authors: Scheible Kristin , Secor‐Socha Shelley , Wightman Terry , Wang Hongyue , Mariani Thomas J. , Topham David J. , Pryhuber Gloria , Quataert Sally 
Published: October 2012

AbstractUmbilical cord blood has been used for a wide variety of immunologic investigations including assessments of developmental perturbations by antenatal exposures. Recent advances in multiparameter flow cytometry have allowed finer characterization of lymphocyte phenotype and function, revealing important differences between the fetal and adult immune systems. The degree of variability between human subjects confounds the ability to draw firm conclusions. Artifacts resulting from processing techniques exacerbate this variability. The unpredictable nature of deliveries, especially of premature infants, makes it difficult to control variables such as timing of umbilical cord mononuclear cell (UCMC) isolation and method of collection. Additionally, in multicenter studies dependent on central processing, delays are inevitable. However, little available literature describes systematic testing of the degree to which processing variations affect UCMC phenotype and function. Using multiparameter flow cytometry, we tested the effect of collection technique and length of time prior to UCMC isolation on T cell phenotype and function, with the goal of creating a standardized operating procedure for a multicenter investigation. The study also provides a benchmark data set including extensive surface and functional phenotyping of umbilical cord T cells. UCMC isolation delay of up to 24 h produced similar T cell phenotype and function as tested by in vitro SEB stimulation. There were few statistically significant differences between time points based on data medians. We conclude that, for the purpose of immunologic investigations, a 24‐h time delay from sample collection to mononuclear cell isolation does not introduce a significant degree of variation in T cell phenotype and function when adhering to strict standard operating procedures. © 2012 International Society for Advancement of Cytometry
QoS‐based radio network dimensioning for LTE networks with heavy real‐time traffic
Authors: Ng Thiaw Seng , Chuah Teong Chee , Tan Yi Fei 
Published: October 2012

SUMMARYApplications of video streaming and real‐time gaming, which generate large amounts of real‐time traffic in the network, are expected to gain considerable popularity in Long Term Evolution networks. Maintaining the QoS such as packet delay, packet loss ratio, median, and cell border throughput requirements in networks dominated by real time traffic, is critical. The existing dimensioning methodology does not consider QoS parameters of real‐time traffic in network dimensioning. Moreover, exhaustive and time‐consuming simulations are normally required to evaluate the performance and QoS of real‐time services. To overcome this problem, we propose an improved radio network dimensioning framework that considers the QoS of real‐time traffic in network dimensioning. In this framework, an analytical model is proposed to evaluate the capacity and performance of real‐time traffic dominant Long Term Evolution networks. The proposed framework provides a fast and accurate means of finding the trade‐off between system load, packet delay, packet loss ratio, required median, and cell border throughput. It also provides network operators with an analytical means for obtaining the minimum number of sites required by jointly considering coverage, capacity and QoS requirements. The accuracy of the proposed model is validated through simulations. Copyright © 2012 John Wiley & Sons, Ltd.
Particle path characteristics at the large gravel‐bed river Danube: results from a tracer study and numerical modelling
Authors: Liedermann Marcel , Tritthart Michael , Habersack Helmut 
Published: October 2012

ABSTRACTA tracer study performed on a 3 km long reach of the Danube River in Austria is presented. Forty artificial stones of three different sizes (intermediate b‐axis: 25 mm, 40 mm, 70 mm) were produced and a coded radio acoustic transmitter was implanted. The measurement system had to be improved to be applicable to large rivers with water depths up to 12 m. The positions of the stones were observed approximately once a week, depending on hydrology, over a period of at least one year by radio‐tracking from a boat, including a 15 year flood event. Transport paths and velocities, as well as the incipient motion of bedload transport, could be monitored for the first time on a large gravel‐bed river. The particle paths were found to be mostly bankline‐parallel, even though the stones passed a 30° river bend. The median of the transverse particle displacement was found to be 4% of the longitudinal displacement. Calculations considering both transverse slope and transverse flow velocities showed transverse transport to be 6·6% of the longitudinal transport indicating that marginal lateral transport is mainly influenced by morphology. A three‐dimensional (3D) numerical model using a stochastic particle tracing approach was validated with the data, indicating that the observed positions are well reproduced by the model. Within the observation period, 74% of all stones passed the reach. With more than 1000 detections, particle transport could be characterized by a mean travel velocity of about 10 m per day (variable for the different grain sizes); single tracer stones were transported up to 1000 m during a single flood event. Size‐selective behaviour could be shown and the incipient motion of the large 70 mm gravel was detected at lower discharges than predicted by commonly used uniform bedload transport formulae. Copyright © 2012 John Wiley & Sons, Ltd.
Development and evaluation of a mechanistic bioconcentration model for ionogenic organic chemicals in fish
Authors: Armitage James M. , Arnot Jon A. , Wania Frank , Mackay Don 
Published: October 2012

Abstract
A mechanistic mass balance bioconcentration model is developed and parameterized for ionogenic organic chemicals (IOCs) in fish and evaluated against a compilation of empirical bioconcentration factors (BCFs). The model is subsequently applied to a set of perfluoroalkyl acids. Key aspects of model development include revised methods to estimate the chemical absorption efficiency of IOCs at the respiratory surface (EW) and the use of distribution ratios to characterize the overall sorption capacity of the organism. Membrane–water distribution ratios (DMW) are used to characterize sorption to phospholipids instead of only considering the octanol–water distribution ratio (DOW). Modeled BCFs are well correlated with the observations (e.g., r2 = 0.68 and 0.75 for organic acids and bases, respectively) and accurate to within a factor of three on average. Model prediction errors appear to be largely the result of uncertainties in the biotransformation rate constant (kM) estimates and the generic approaches for estimating sorption capacity (e.g., DMW). Model performance for the set of perfluoroalkyl acids considered is highly dependent on the input parameters describing hydrophobicity (i.e., log KOW of the neutral form). The model applications broadly support the hypothesis that phospholipids contribute substantially to the sorption capacity of fish, particularly for compounds that exhibit a high degree of ionization at biologically relevant pH. Additional empirical data on biotransformation and sorption to phospholipids and subsequent incorporation into property estimation approaches (e.g., kM, DMW) are priorities with respect to improving model performance. Environ. Toxicol. Chem. 2013;32:115–128. © 2012 SETAC
Protective and antioxidant role of selenium on arsenic trioxide–induced oxidative stress and genotoxicity in the fish hepatoma cell line PLHC-1
Authors: Selvaraj Vellaisamy , Yeager-Armstead Mindy , Murray Elizabeth 
Published: October 2012

Abstract
In vitro models are useful tools for rapid screening for toxicity, elucidation of mechanisms of toxicity, and understanding complex interactions among environmental toxicants. These evaluations may provide useful information for ecological evaluations if the relationship between in vitro and in vivo effects is established. The present study was undertaken to evaluate the protective effect of selenium on arsenic trioxide (As2O3)–induced cytotoxicity, DNA damage, and apoptosis. N-acetylcysteine (NAC), a free radical scavenger, was used to determine the involvement of reactive oxygen species (ROS) in As2O3-induced DNA damage and apoptosis. Poeciliopsis lucida hepatocellular carcinoma line 1 (PLHC-1) cells were pretreated with selenium (1, 5, and 10 µM) and NAC (50 and 100 µM) for 2 h. After pretreatment, cells were exposed to 100 µM of As2O3 for 10-, 20-, and 40-h intervals. The As2O3 exposure promoted extensive DNA damage and apoptosis compared to control, while selenium- and NAC-pretreated cells improved cell survival rate against As2O3-induced cell death. Improved survival likely resulted from increasing glutathione peroxidase activity and reduction of ROS formation, reduction of mitochondrial membrane potential damage, DNA damage, and caspase-3 activity. During As2O3 exposure, selenium played the same role as NAC. The authors conclude that As2O3-induced DNA damage and apoptosis are mediated by oxidative stress and selenium and that, although toxic at higher concentrations, selenium provides significant protection against As2O3 effects in PLHC-1 cells. Environ. Toxicol. Chem. 2012; 31: 2861–2869. © 2012 SETAC
Cross‐layer optimization for fair end‐to‐end rate allocation in WMNs with MIMO links
Authors: Bansal M. , Trivedi A. 
Published: October 2012

ABSTRACTMultiple‐input multiple‐output (MIMO) technology can bring substantial throughput improvement in wireless mesh networks (WMNs) via a combination of interference suppression and spatial multiplexing. In this paper, we investigate a cross‐layer design problem in MIMO‐based WMNs, which involves end‐to‐end rate allocation, routing, and stream control scheduling. Scheduling is addressed by using a set of transmission configurations (TCs), and a greedy heuristic algorithm is proposed to identify a good subset of all possible TCs. We define three optimization problems to find the maximum throughput, max–min fair and proportional fair rate allocation solutions. We propose a cross‐layer scheme to solve these problems. We also discuss how the proposed cross‐layer scheme can be implemented on the basis of the IEEE 802.16 mesh mode. Simulation results show that the performance of the proposed schemes with the heuristic algorithm is close to the optimal. The computational complexity of obtaining the solution using the proposed heuristic algorithm is substantially less than that of finding the optimal solution. Copyright © 2012 John Wiley & Sons, Ltd.
A high‐order accurate discontinuous Galerkin finite element method for laminar low Mach number flows
Authors: Nigro A. , Renda S. , De Bartolo C. , Hartmann R. , Bassi F. 
Published: October 2012

SUMMARYIn this paper we present a discontinuous Galerkin (DG) method designed to improve the accuracy and efficiency of laminar flow simulations at low Mach numbers using an implicit scheme. The algorithm is based on the flux preconditioning approach, which modifies only the dissipative terms of the numerical flux. This formulation is quite simple to implement in existing implicit DG codes, it overcomes the time‐stepping restrictions of explicit multistage algorithms, is consistent in time and thus applicable to unsteady flows. The performance of the method is demonstrated by solving the flow around a NACA0012 airfoil and on a flat plate, at different low Mach numbers using various degrees of polynomial approximations. Computations with and without flux preconditioning are performed on different grid topologies to analyze the influence of the spatial discretization on the accuracy of the DG solutions at low Mach numbers. The time accurate solution of unsteady flow is also demonstrated by solving the vortex shedding behind a circular cylinder at the Reynolds number of 100. Copyright © 2012 John Wiley & Sons, Ltd.
Determinants of central nervous system adult neurogenesis are sex, hormones, mouse strain, age, and brain region
Authors: Tatar Carrie , Bessert Denise , Tse Harley , Skoff Robert P. 
Published: October 2012

AbstractMultiple sclerosis is a sexually dimorphic (SD) disease that causes oligodendrocyte death, but SD of glial cells is poorly studied. Here, we analyze SD of neural progenitors in 6–8 weeks and 6–8 months normal C57BL/6, SJL/J, and BALB/c mice in the subventricular zone (SVZ), dorsolateral horn (DLC), corpus callosum (CC), and parenchyma. With a short 2‐h bromodeoxyuridine (BrdU) pulse, no gender and strain differences are present at 6–8 weeks. At 6–8 months, the number of BrdU+ cells decreases twofold in each sex, strain, and region, indicating that a common aging mechanism regulates BrdU incorporation. Strikingly, 2× more BrdU+ cells are found in all brain regions in 6–8 months C57BL/6 females versus males, no gender differences in 6–8 months SJL/J, and fewer BrdU+ cells in females versus males in BALB/cs. The number of BrdU+ cells modestly fluctuates throughout the estrous cycle in C57BL/6 and SJLs. Castration causes a dramatic increase in BrdU+ cells in SVZ and DLC. These findings indicate that testosterone is a major regulator of adult neural proliferation. At 6–8 months, the ratio of PDGFRα+ cells in the CC to BrdU+ cells in the DLC of both strains, sexes, estrous cycle, and castrated mice was essentially the same, suggesting that BrdU+ cells in the DLC differentiate into CC oligodendrocytes. The ratio of TUNEL+ to BrdU+ cells does not match proliferation, indicating that these events are differentially regulated. Differential regulation of these two processes leads to the variation in glial numbers between gender and strain. Explanations of neural proliferation based upon data from one sex or strain may be very misleading. © 2012 Wiley Periodicals, Inc.
HDAC11 is a novel drug target in carcinomas
Authors: Deubzer Hedwig E. , Schier Marie C. , Oehme Ina , Lodrini Marco , Haendler Bernard , Sommer Anette , Witt Olaf 
Published: October 2012

AbstractInhibition of histone deacetylase (HDAC) activity as stand‐alone or combination therapy represents a promising therapeutic approach in oncology. The pan‐ or class I HDAC inhibitors (HDACi) currently approved or in clinical studies for oncology give rise to dose‐limiting toxicities, presumably because of the inhibition of several HDACs. This could potentially be overcome by selective blockade of single HDAC family members. Here we report that HDAC11, the most recently identified zinc‐dependent HDAC, is overexpressed in several carcinomas as compared to corresponding healthy tissues. HDAC11 depletion is sufficient to cause cell death and to inhibit metabolic activity in HCT‐116 colon, PC‐3 prostate, MCF‐7 breast and SK‐OV‐3 ovarian cancer cell lines. The antitumoral effect induced can be mimicked by enforced expression of a catalytically impaired HDAC11 variant, suggesting that inhibition of the enzymatic activity of HDAC11 by small molecules could trigger the desired phenotypic changes. HDAC11 depletion in normal cells causes no changes in metabolic activity and viability, strongly suggesting that tumor‐selective effects can be achieved. Altogether, our data show that HDAC11 plays a critical role in cancer cell survival and may represent a novel drug target in oncology.
Type 2 diabetes mellitus, insulin‐use and risk of bladder cancer in a large cohort study
Authors: Newton Christina C. , Gapstur Susan M. , Campbell Peter T. , Jacobs Eric J. 
Published: October 2012

AbstractType 2 diabetes mellitus (T2DM) is associated with increased bladder cancer incidence in some, but not all, studies. Many studies had limited statistical power and few examined risk by insulin‐use, duration of diabetes or cancer stage. We examined the association between T2DM and bladder cancer incidence in the Cancer Prevention Study II Nutrition Cohort, a large prospective study with information on insulin‐use and duration of diabetes. Diabetes and insulin‐use were ascertained from a questionnaire at study enrollment in 1992 or 1993 and updated in 1997 and every 2 years thereafter. During follow‐up through 2007, 1,852 cases of incident bladder cancer were identified among 172,791 participants. Multivariable adjusted relative risks (RRs) and 95% confidence intervals (CIs) were estimated using extended Cox regression modeling. There were no associations of T2DM with the risk of bladder cancer overall (RR = 1.01, 95% CI: 0.87–1.17), noninvasive disease (RR = 0.93, 95% CI: 0.76–1.14) or invasive disease (RR = 1.13, 95% CI: 0.91–1.40). Compared to participants without T2DM, risk of invasive bladder cancer was higher among participants who had had T2DM for >15 years (RR = 1.63, 95% CI: 1.09–2.43) and among those using insulin (RR = 1.64, 95% CI: 1.18–2.27). These results do not support an association of T2DM with overall bladder cancer incidence, but do suggest positive associations of long‐term T2DM and insulin‐use or other factors correlated with severe diabetes, with invasive bladder cancer incidence.
4.1: Distinguished Student Paper: Low‐Voltage and Hysteresis‐Free Blue‐Phase LCD with Vertical Field Switching
Authors: Cheng Hui‐Chuan , Yan Jin , Ishinabe Takahiro , Tsai Cheng‐Yeh , Lin Ching‐Huan , Huang Tai‐Hsiang , Liu Kang‐Hung , Liu Chu‐Yu , Sugiura Norio , Liau Wei‐Lung , Wu Shin‐Tson 
Published: October 2012

AbstractWe report a new polymer‐stabilized blue‐phase liquid crystal display with vertical field switching (VFS) and oblique incident backlight. This VFS mode offers several attractive features, such as low operation voltage, high transmittance, submillisecond response time, and negligible hysteresis and residual birefringence.
4.4: New Materials for Polymer‐Stabilized Blue Phase
Authors: Wittek Michael , Tanaka Norihiko , Wilkes David , Bremer Matthias , Pauluth Detlef , Canisius Johannes , Yeh Aska , Yan Ray , Skjonnemand Karl , Klasen‐Memmer Melanie 
Published: October 2012

AbstractElectro‐optical switching of the liquid crystalline Blue Phase exhibits extremely fast response times. However, the unstabilized Blue Phase is characterized by a rather narrow temperature range on the order of a few K. For display applications the operating temperature range needs to be increased. One very promising way is to broaden the stable temperature range by polymer‐stabilization of the Blue Phase. Successful stabilization is achieved by proper material selection/matching of reactive mesogens (RMs) and the chiral host. One prerequisite for application in display manufacturing is excellent UV and heat stability as well as good processability. Improvements in relevant performance parameters will be presented and discussed.
6.3: A New Method for Hot‐Spot and Mura Quantification and Evaluation in LCD Backlight Units and Panel
Authors: Chen Li‐Xuan , Kang Chih‐Tsung 
Published: October 2012

AbstractA convenient method to quantificationally and objectively describe the grade of hot‐spot and mura of Liquid Crystal Display is introduced. By converting the spatial backlight unit luminance distribution of a Liquid Crystal Display to frequency domain, Fast Fourier transform is used for luminance variation analysis. The results not only give a factor which can quantificationally describe the grade of hot‐spot and mura of a LCD backlight unit area but also unify different experimental processes that using a camera or a Radiant Imaging ProMetric 1400 system keeping the results consistent.
7.2: Fast‐Addressing Waveform with Negative‐Going Ramp for High‐Xe PDP with High‐Gamma Cathode Materials
Authors: Whang Ki‐Woong , Cheong Hee‐Woon , Kwon Ohyung 
Published: October 2012

AbstractIn this paper, the address discharge characteristics of high‐Xe PDPs with high‐gamma cathode materials were investigated. It will be shown that the address discharge characteristics such as the dynamic voltage margin and the address discharge time lag of high‐Xe PDP with MgO‐SrO double cathode layer and one with MgCaO single cathode layer can be improved by inducing stable, continuous weak discharges during the reset period with a newly designed waveform. The deposition of pure MgO powder on high gamma cathode material has also proved to be effective in reducing the address discharge time lag of high‐Xe PDP.
7.3: Distinquished Paper: Ultra‐Thin Shadow‐Mask PDP Fabricated by Vacuum In‐line Sealing Technology
Authors: Yang Lanlan , Tu Yan , Zhang Xiong , Tolner Harm , Jin Ye , Zhang Panpan , Wang Baoping 
Published: October 2012

AbstractAn ultra‐thin shadow mask plasma display panel is put forward to meet the market demands of a much thinner, lighter and flexible display. Thanks to the ultra‐thin 70μm thick glass, a special vacuum in‐line sealing technology could be used to fabricate the novel device without a pumping tube. The sealed panel is only 300μm thick. The sealing characteristics and the discharge characteristics are investigated. The experimental results indicate that a high ratio of Xe in the gas mixture can be used, thereby improving the performance of the ultra‐thin SMPDP. In future applications AF32 type of foil glass will be used with a dielectric constant of 5.1. In addition a sealing temperature of 600 °C or higher will enable to exploit the full benefits of MgCaO protective layer. The ultra‐thin panel is well suited both for a double‐sided display and for 3D‐display.
8.2: Flexible N‐type Organic Thin Film Transistors
Authors: Hung Wei‐Lun , Yang Ming‐Che , Tu Chia‐Hsun , Hung Shih‐Hsing , Hwu Keh‐Long , Hu Chih‐Jen , Huang Wei‐Ming 
Published: October 2012

AbstractN‐type organic thin film transistors have been successfully fabricated on G1 production line. Simple solution‐spin‐coating method followed by conventional photolithography process is used for all organic thin film deposition and patterning in the devices The devices can be used for electrophoretic display (EPD).