bluuebunny/crossref_metadata_2025_split huggingface dataset:
An all-optical modulation method in sub-micron scale
Authors: Yang Longzhi , Pei Chongyang , Shen Ao , Zhao Changyun , Li Yan , Li Xia , Yu Hui , Li Yubo , Jiang Xiaoqing , Yang Jianyi 
Published: March 2015

AbstractWe report a theoretical study showing that by utilizing the illumination of an external laser, the Surface Plasmon Polaritons (SPP) signals on the graphene sheet can be modulated in the sub-micron scale. The SPP wave can propagate along the graphene in the middle infrared range when the graphene is properly doped. Graphene's carrier density can be modified by a visible laser when the graphene sheet is exfoliated on the hydrophilic SiO2/Si substrate, which yields an all-optical way to control the graphene's doping level. Consequently, the external laser beam can control the propagation of the graphene SPP between the ON and OFF status. This all-optical modulation effect is still obvious when the spot size of the external laser is reduced to 400 nm while the modulation depth is as high as 114.7 dB/μm.
Developmental white matter microstructure in autism phenotype and corresponding endophenotype during adolescence
Authors: Lisiecka D M , Holt R , Tait R , Ford M , Lai M-C , Chura L R , Baron-Cohen S , Spencer M D , Suckling J 
Published: March 2015

AbstractDuring adolescence, white matter microstructure undergoes an important stage of development. It is hypothesized that the alterations of brain connectivity that have a key role in autism spectrum conditions (ASCs) may interact with the development of white matter microstructure. This interaction may be present beyond the phenotype of autism in siblings of individuals with ASC, who are 10 to 20 times more likely to develop certain forms of ASC. We use diffusion tensor imaging to examine how white matter microstructure measurements correlate with age in typically developing individuals, and how this correlation differs in n=43 adolescents with ASC and their n=38 siblings. Correlations observed in n=40 typically developing individuals match developmental changes noted in previous longitudinal studies. In comparison, individuals with ASC display weaker negative correlation between age and mean diffusivity in a broad area centred in the right superior longitudinal fasciculus. These differences may be caused either by increased heterogeneity in ASC or by temporal alterations in the group’s developmental pattern. Siblings of individuals with ASC also show diminished negative correlation between age and one component of mean diffusivity—second diffusion eigenvalue—in the right superior longitudinal fasciculus. As the observed differences match for location and correlation directionality in our comparison of typically developing individuals to those with ASC and their siblings, we propose that these alterations constitute a part of the endophenotype of autism.
PAB is an assembly chaperone that functions downstream of chaperonin 60 in the assembly of chloroplast ATP synthase coupling factor 1
Authors: Mao Juan , Chi Wei , Ouyang Min , He Baoye , Chen Fan , Zhang Lixin 
Published: March 2015

Significance
The assembly of chloroplast ATP synthase, a multiprotein complex made of subunits of mixed genetic origin, is essential for organelle biogenesis and organism survival. Assembly of multiprotein complexes relies not only on the proper action of universal folding chaperones but also on that of specific assembly chaperones that orchestrate the joining of individual components into higher-order complexes. In this work, we have identified a specific assembly chaperone for chloroplast ATP synthase and shown that it functions downstream of the Cpn60 chaperone to promote assembly of the catalytically active core of the chloroplast ATP synthase. Such collaboration between folding and assembly chaperones appears to be a widely used cellular strategy for the folding and assembly of nucleus-encoded proteins into multiprotein photosynthetic complexes.
Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate
Authors: Wu Fuguo , Kaczynski Tadeusz J. , Sethuramanujam Santhosh , Li Renzhong , Jain Varsha , Slaughter Malcolm , Mu Xiuqian 
Published: March 2015

Significance
Despite the progress made during the last two decades regarding the generation of retinal cell types, the mechanisms by which a retinal progenitor cell decides to adopt a particular cell type remain unclear. Using a binary knockin-transgenic system, we show that two factors, POU domain, class 4, transcription factor 2 (Pou4f2) and insulin gene enhancer protein 1 (Isl1), specify the retinal ganglion cell (RGC) fate and activate the whole gene-expression program required for ganglion cell differentiation. This study, for the first time to our knowledge, defines a set of determinant factors for any retinal cell type, offering significant insight into how cellular diversity is achieved in the central nervous system. It also provides guidance for generating RGCs in vitro for therapeutic purposes.
Adult hippocampal neural stem and progenitor cells regulate the neurogenic niche by secreting VEGF
Authors: Kirby Elizabeth D. , Kuwahara Akela A. , Messer Reanna L. , Wyss-Coray Tony 
Published: March 2015

Significance
Adult hippocampal neurogenesis is a lifelong process by which new neurons are derived from a pool of resident stem and progenitor cells. Research on the functional role of this process has, to date, focused on the contributions of new, highly plastic neurons to memory function. We show here a previously unidentified functional role of undifferentiated neural stem and progenitor cells in the adult hippocampus as secretory cells that help maintain their own neurogenic niche by secreting large, biologically relevant quantities of the essential growth factor, VEGF. These findings suggest that the function of adult neurogenesis may include the secretome of undifferentiated stem and progenitor cells.
Molecular ruler determines needle length for the
Salmonella
Spi-1 injectisome
Authors: Wee Daniel H. , Hughes Kelly T. 
Published: March 2015

Significance
Type-III secretion systems facilitate the virulence capability of Gram-negative bacterial pathogens. They are part of complex nanomachines that include the bacterial flagellum, which confers motility, and the injectisome, which secretes proteins from the infecting bacterial cytoplasm into eukaryotic host cells. Here we examine the mechanisms of length control for the main component of the injectisome and flagellar basal structures, the needle and the hook, respectively. The defined lengths of the hook and needle are important for their function. We find that both systems use a secreted, molecular ruler to effect length determination at the nanometer-scale. Understanding the mechanisms of length control in these systems provides insight into bacterial pathogens and a biological model for the controlled construction of nanomaterials.
Herpes simplex viral-vector design for efficient transduction of nonneuronal cells without cytotoxicity
Authors: Miyagawa Yoshitaka , Marino Pietro , Verlengia Gianluca , Uchida Hiroaki , Goins William F. , Yokota Shinichiro , Geller David A. , Yoshida Osamu , Mester Joseph , Cohen Justus B. , Glorioso Joseph C. 
Published: March 2015

Significance
Gene therapy has made significant strides in the treatment and even cure of single-gene defects. However, the maturation of this field will require more sophisticated vehicles capable of cell-selective delivery of large genetic payloads whose regulated expression will restore or enhance cellular functionality. High-capacity herpes simplex virus vectors have the potential to meet these challenges but have been limited by the need to preserve one particularly cytotoxic viral product, infected cell polypeptide 0, to maintain transgene transcriptional activity. Our study describes a vector design that solves this conundrum, thereby promising the near-term availability of viral vectors that can efficiently deliver large or multiple regulated transgenes to a diversity of cells without attendant cytotoxicity.
Microdroplet fusion mass spectrometry for fast reaction kinetics
Authors: Lee Jae Kyoo , Kim Samuel , Nam Hong Gil , Zare Richard N. 
Published: March 2015

Significance
Time-resolved mass spectrometry is a powerful approach for identifying reaction intermediates and measuring reaction kinetics, yet one critical limitation is temporal resolution. Here, we describe microdroplet fusion mass spectrometry on timescales as short as microseconds. In our approach, two high-speed streams of liquid microdroplets collide to make fused droplets of 13 ± 6 μm in diameter, where the reactants are mixed in a negligible time. After a short flying time of 50 μs or less during which the reaction proceeds, the fused droplets enter a mass spectrometer for chemical analysis of intermediates and reaction products. This enables observation of early events of various fast chemical reactions in the liquid phase.
The taste system of small fish species
Authors: Okada Shinji 
Published: March 2015

Abstract
Small fish species such as the zebrafish (Danio rerio) and medaka fish (Oryzias latipes) are advantageous animal models and have been used as model organisms in many research areas. However, they have not been utilized for studying the taste system, primarily because of a dearth of molecular biological knowledge. Quantitative methods for analyzing the taste preferences of fish species have also been lacking. Recent progress of the fish genome project has enabled the elucidation of the molecular mechanisms of taste sensation. Taste receptors and a number of signal transduction molecules have been identified. Additionally, the development of quantitative methods of feeding using fluorescently labeled artificial foods has demonstrated taste preferences in small fish species. Comparisons between these results in fish and reports on mammals have proposed a general logic and evolution of vertebrate taste systems. Analysis on the transsynaptic tracer-expressing transgenic medaka fish also suggests the usefulness of small fish in the research of neural circuits for taste.
Cardinal: an R package for statistical analysis of mass spectrometry-based imaging experiments
Authors: Bemis Kyle D. , Harry April , Eberlin Livia S. , Ferreira Christina , van de Ven Stephanie M. , Mallick Parag , Stolowitz Mark , Vitek Olga 
Published: March 2015

Abstract
Cardinal is an R package for statistical analysis of mass spectrometry-based imaging (MSI) experiments of biological samples such as tissues. Cardinal supports both Matrix-Assisted Laser Desorption/Ionization (MALDI) and Desorption Electrospray Ionization-based MSI workflows, and experiments with multiple tissues and complex designs. The main analytical functionalities include (1) image segmentation, which partitions a tissue into regions of homogeneous chemical composition, selects the number of segments and the subset of informative ions, and characterizes the associated uncertainty and (2) image classification, which assigns locations on the tissue to pre-defined classes, selects the subset of informative ions, and estimates the resulting classification error by (cross-) validation. The statistical methods are based on mixture modeling and regularization.
Contact: o.vitek@neu.edu
Availability and implementation: The code, the documentation, and examples are available open-source at www.cardinalmsi.org under the Artistic-2.0 license. The package is available at www.bioconductor.org.
Casitas: a location-dependent ecological trap for juvenile Caribbean spiny lobsters, Panulirus argus
Authors: Gutzler Benjamin C. , Butler Mark J. , Behringer Donald C. 
Published: March 2015

AbstractCasitas are artificial shelters used by fishers to aggregate Caribbean spiny lobsters (Panulirus argus) for ease of capture. However, casitas may function as an ecological trap for juvenile lobsters if they are attracted to casitas and their growth or mortality is poorer compared with natural shelters. We hypothesized that juvenile lobsters may be at particular risk if attracted to casitas because they are less able than larger individuals to defend themselves, and do not forage far from shelter. We compared the nutritional condition, relative mortality, and activity of lobsters of various sizes in casitas and natural shelters in adult and juvenile lobster-dominated habitats in the Florida Keys (United States). We found that the ecological effects of casitas are complex and location-dependent. Lobsters collected from casitas and natural shelters did not differ in nutritional condition. However, juvenile lobsters in casitas experienced higher rates of mortality than did individuals in natural shelters; the mortality of large lobsters did not differ between casitas and natural shelters. Thus, casitas only function as ecological traps when deployed in nursery habitats where juvenile lobsters are lured by conspecifics to casitas where their risk of predation is higher. These results highlight the importance of accounting for animal size and location-dependent effects when considering the consequences of habitat modification for fisheries enhancement.
mRNA maturation in giant viruses: variation on a theme
Authors: Priet Stéphane , Lartigue Audrey , Debart Françoise , Claverie Jean-Michel , Abergel Chantal 
Published: March 2015

AbstractGiant viruses from the Mimiviridae family replicate entirely in their host cytoplasm where their genes are transcribed by a viral transcription apparatus. mRNA polyadenylation uniquely occurs at hairpin-forming palindromic sequences terminating viral transcripts. Here we show that a conserved gene cluster both encode the enzyme responsible for the hairpin cleavage and the viral polyA polymerases (vPAP). Unexpectedly, the vPAPs are homodimeric and uniquely self-processive. The vPAP backbone structures exhibit a symmetrical architecture with two subdomains sharing a nucleotidyltransferase topology, suggesting that vPAPs originate from an ancestral duplication. A Poxvirus processivity factor homologue encoded by Megavirus chilensis displays a conserved 5′-GpppA 2′O methyltransferase activity but is also able to internally methylate the mRNAs’ polyA tails. These findings elucidate how the arm wrestling between hosts and their viruses to access the translation machinery is taking place in Mimiviridae.
Food advertising as a mirror of intercultural differences: the case of the UK and Greece
Authors: Theocharous Andriani 
Published: March 2015

Purpose
– The purpose of this paper is to identify cultural preferences in advertising style in the UK and Greece through the comparison of advertisements for food products of local brands.

Design/methodology/approach
– In total, 39 advertisements were collected from local food magazines in 2012-2013. Each copy was content-analyzed based on three dimensions of advertising style: advertising forms, appeals, and verbal communication style.

Findings
– The analysis of the copies shows a tendency for Greek advertisements to adopt a forceful style and to convey an abundance of factual information in direct forms, combined with emotional appeals emphasizing local origin, nostalgia, and long-standing cultural traditions. On the contrary, UK copies tend to emphasize the entertainment value of advertisements, while communicating rational appeals in an informal register.

Research limitations/implications
– The variations in advertising style for the promotion of food products in the UK and Greece reflect the different ways in which advertising works, and potential differences in consumers’ decision making when it comes to the purchase of the products. The findings could have relevance for the design and transcreation of multinational food campaigns, and they could facilitate the development of research questions to be addressed in food marketing and advertising and consumer behaviour research.

Originality/value
– The study adopts an interdisciplinary approach to the analysis of the copies and the interpretation of findings, which draws on marketing and advertising and integrates a linguistic analysis of the text. By focusing on a particular product category and origin, it attempts to comprehensively account for their effect on advertising practices.
Nutrition information and its influence on menu choice within higher education establishments
Authors: Feldman Charles H. , Hartwell Heather , Brusca Joseph , Su Haiyan , Zhao Hang 
Published: March 2015

Purpose
– The purpose of this paper is to evaluate the influence of nutritional information on menu choices in a higher educational setting using a menu designed by the students themselves.

Design/methodology/approach
– Based on USDA healthy eating standards, a menu comprising seven healthy and seven unhealthy meal options were presented, once unlabeled as control (n=214) and once labeled with healthy and non-healthy nutrient icons as an intervention test menu (n=212).

Findings
– Findings demonstrate that despite a positive observed trend, there were no significant differences between healthy selection of labeled and unlabeled dishes (p=0.16).

Practical implications
– Providing nutritional information in student cafeterias may be challenging but helpful. However, more strategies need to be developed with student input to provide nutrition data on menus in an informative, comprehensive, yet friendly way that encourages healthy eating in campus foodservices.

Social implications
– No labeling system or legislation can control choices made by individuals, so the responsibility for a healthy selection must always remain personal. However, consumers should have input on menus as they have a stake in the outcome of the products.

Originality/value
– This novel study tested a student-designed menu to assess whether user input can influence food choice.
How to optimize the cost and time of the acquisitions process?
Authors: Kont Kate-Riin 
Published: March 2015

Purpose
– The purpose of this paper is to focus on the history and new developments of the optimization and analysis of acquisitions costs. More specifically, the acquisition cost and time optimization methods studied concern primarily print format books. Though e-books have begun to be developed more and more, the print format books – both scientific books and textbooks – are still very important for university libraries and continue to pour into acquisition activities.

Design/methodology/approach
– The data used in this paper are based on a review of relevant literature to provide an overview of the different concepts of the budget allocation and cost accounting methods suitable for the optimizing cost and time of the acquisition process. Different methods are described via reviewing example studies.

Findings
– On the basis of the current study, it can be said that the acquisitions procedure is more labor-intensive than any other library procedure both historically and nowadays. Nonetheless, the routines of acquisitions have been fairly well fixed over the years and constantly have searched for new ways to reduce costs. The most popular methods to control the acquisitions budget have been centralized and cooperative acquisitions, using vendors for acquiring library materials, customer-based acquisitions, and price indexes. New costing methods described, like activity-based costing and time-driven activity-based costing methodologies seem both to be the best tools for understanding acquisitions cost behavior and for refining a cost system for university libraries.

Originality/value
– This paper raises a perspective in library acquisitions management that has not been dealt with before. Namely, it explores how the library materials selection moved from intrinsic wisdom of bookish librarians and “just in case” inventory model to “purchase by customer suggestion” model. In addition, how libraries moved from acting on the basis of guesses to examine the cost breakdown of the acquisitions-related activities in a library.
The internet as a data source for advancement in social sciences
Authors: Askitas Nikolaos , Zimmermann Klaus F. 
Published: March 2015

Purpose– The purpose of this paper is to recommend the use of internet data for social sciences with a special focus on human resources issues. It discusses the potentials and challenges of internet data for social sciences. The authors present a selection of the relevant literature to establish the wide spectrum of topics, which can be reached with this type of data, and link them to the papers in thisInternational Journal of Manpowerspecial issue.Design/methodology/approach– Internet data are increasingly representing a large part of everyday life, which cannot be measured otherwise. The information is timely, perhaps even daily following the factual process. It typically involves large numbers of observations and allows for flexible conceptual forms and experimental settings.Findings– Internet data can successfully be applied to a very wide range of human resource issues including forecasting (e.g. of unemployment, consumption goods, tourism, festival winners and the like), nowcasting (obtaining relevant information much earlier than through traditional data collection techniques), detecting health issues and well-being (e.g. flu, malaise and ill-being during economic crises), documenting the matching process in various parts of individual life (e.g. jobs, partnership, shopping), and measuring complex processes where traditional data have known deficits (e.g. international migration, collective bargaining agreements in developing countries). Major problems in data analysis are still unsolved and more research on data reliability is needed.Research limitations/implications– The data in the reviewed literature are unexplored and underused and the methods available are confronted with known and new challenges. Current research is highly original but also exploratory and premature.Originality/value– The paper reviews the current attempts in the literature to incorporate internet data into the mainstream of scholarly empirical research and guides the reader through this Special Issue. The authors provide some insights and a brief overview of the current state of research.
Consumer software piracy in virtual communities
Authors: Yu Chia-ping , Young Mei-Lien , Ju Bao-Chang 
Published: March 2015

Purpose
– In consumer marketing literature, the ethical/moral components of consumer behavior have been recognized as important factors in individuals’ involvement in software piracy. However, there remains unanswered the question of which specific components are being referred to and how they explain consumer software piracy in the virtual knowledge-sharing community. This question is particularly unaddressed for those consumers who take the risks associated with piracy believing their acts to be taking from the haves (software producers) and giving to the have-nots. The paper aims to discuss this issue.

Design/methodology/approach
– In this research, the authors propose a synergistic model that adopts the perspective of heroism and social exchange, and test it with the data collected from a virtual community. To test the proposed research model, the authors investigated 489 subjects and examined the hypotheses by applying the partial least squares method.

Findings
– The findings show that the heroism construct has significant influence on sharing behavior in relation to cost factors, but not to benefit factors. Heroism stands out as the major construct in explaining sharing behavior. Thus, the research shows that the consumer software piracy present in the virtual knowledge-sharing community is a social behavior of exchange.

Originality/value
– Methodologically, the study proposes a new model for researchers and practitioners to understand consumer software piracy in the virtual community. Managerially, software producers should take it into consideration when formulating their product-pricing strategy, to ensure that software producers and the young can both win in the “buy or steal” war.