bluuebunny/crossref_metadata_2025_split huggingface dataset:
DIS3 ribonuclease is essential for spermatogenesis and male fertility in mice
Authors: Wang Zhengpin , Wu Di , Xu Xiaojiang , Yu Guoyun , Li Nana , Wang Xiao , Li Jian-Liang , Dean Jurrien 
Published: July 2024

ABSTRACT
Spermatogonial stem cell (SSC) self-renewal and differentiation provide foundational support for long-term, steady-state spermatogenesis in mammals. Here, we have investigated the essential role of RNA exosome associated DIS3 ribonuclease in maintaining spermatogonial homeostasis and facilitating germ cell differentiation. We have established male germ-cell Dis3 conditional knockout (cKO) mice in which the first and subsequent waves of spermatogenesis are disrupted. This leads to a Sertoli cell-only phenotype and sterility in adult male mice. Bulk RNA-seq documents that Dis3 deficiency partially abolishes RNA degradation and causes significant increases in the abundance of transcripts. This also includes pervasively transcribed PROMoter uPstream Transcripts (PROMPTs), which accumulate robustly in Dis3 cKO testes. In addition, scRNA-seq analysis indicates that Dis3 deficiency in spermatogonia significantly disrupts RNA metabolism and gene expression, and impairs early germline cell development. Overall, we document that exosome-associated DIS3 ribonuclease plays crucial roles in maintaining early male germ cell lineage in mice.
Improving healthcare transition for young people with cancer: factors fundamental to the quality improvement journey
Authors: Potter Emma , Lewis Ciara , Tilbury Angus , Tong Jason , Sipanoun Pippa 
Published: July 2024

Background: Young people receiving cancer treatment in the South Thames Children's, Teenagers' and Young Adults' Cancer Operational Delivery Network usually receive care across two or more NHS trusts, meaning transition into adult services can be challenging. Aim: To develop a planned, co-ordinated approach to transition across the network that meets National Institute for Health and Care Excellence guidance recommendations for transition and the cancer service specifications. Methods: A 2-year, nurse-led quality improvement (QI) project, using the principles of experience-based co-design. Outcomes: The QI project resulted in the development of six key principles of practice; refining and testing of a benchmarking tool; initiatives to facilitate first transition conversations; and the launch of an information hub. Conclusion: Robust QI processes, cross-network collaboration and wide stakeholder involvement required significant resource, but enabled deeper understanding of existing pathways and processes, facilitated the establishment of meaningful objectives, and enabled the testing of interventions to ensure the project outcomes met the needs of all stakeholders.
Double-link-failure-tolerant shared protection for fully coupled/half-split switchable point-to-multipoint coherent optical systems
Authors: Kodama Takahiro , Nakagawa Tomoya , Eguchi Shota , Shimada Keiji , Matsumoto Ryosuke 
Published: July 2024

Beyond 5G, the next-generation wireless communication standard requires an optical communication network with a more reliable point-to-multipoint system. A highly reliable, futuristic point-to-multipoint coherent optical system must update wavelength-division-multiplexing-based passive optical networks to a more disaster-resistant architecture that can switch between bypass and backup links. We propose, to our knowledge, a novel link-pair shared protection that can respond locally to double-link failures that result from a significant disaster. We validate the high availability of several network configurations, assuming a double-link disconnection, can be obtained irrespective of the transmission distance of the feeder fiber. We experimentally demonstrate link-pair shared protection with bidirectional wavelength pre-assignment for two of the four feeder fiber failures and validate a penalty of less than 2 dB for double-link failures. Furthermore, we prove that reconnection can be performed with a penalty of at most 2 dB in an experiment with shared protection with a single-link broadcast-and-select function that can manage partial double-link failures using a simple configuration.
Vergleich der Umsetzungsoptionen für Steuersysteme im Verbund im Energiesektor: Sicherheitsanforderungen, Effizienz und Wirksamkeit auf zentraler und dezentraler Ebene
Authors: Müller Sven , Müller Kevin , Hartmann Kilian , Weindl Christian 
Published: July 2024

ZusammenfassungDer stetige Wandel von einer auf fossilen Rohstoffen basierenden Energieversorgung hin zu einer Versorgung auf Basis erneuerbarer Energien dient u. a. dem Ziel der Reduzierung des Kohlenstoffdioxidausstoßes. Dieser Wandel führt neben der Einsparung von Kohlenstoffdioxid zu einem Handlungsbedarf im Stromnetz, da durch die Substitution von steuerbaren durch dargebotsabhängige Erzeuger der Ausgleich zwischen Last und Erzeugung nicht mehr wie bisher durchgeführt werden kann. Ein möglicher Ansatz zur Lösung dieses Problems, ist zusätzlich zum Netzausbau die Ausgestaltung eines Smart Grids, welches durch Steuersysteme anhand verschiedener Netz‑, Umwelt- sowie ökonomischer Parameter erreicht werden kann.Dieser Artikel untersucht verschiedene zentrale und dezentrale Konzepte für die Datenhaltung in Smart Grid-Steuersystemen sowie die Datenverarbeitung, wobei hier die Aspekte der lokalen und der cloudbasierten Verarbeitung betrachtet werden. Betrachtungsgegenstand bei der Datenhaltung sind relationale Datenbanken, Blockchain und NoSQL-Datenbanken. Nach einem Vergleich der verschiedenen Konzepte anhand der Parameter Datensicherheit, Konsistenz, Skalierbarkeit, Kosten, Latenz, Verfügbarkeit und Komplexität sowie einer Abstimmung mit den Anforderungen eines zuvor definierten Use-Case wird eine Beurteilung darüber abgegeben, welches Konzept am besten den Anforderungen entspricht. Der Beitrag schließt mit einem Ausblick und einer Handlungsempfehlung. Eine ausführliche Analyse für die Datenverarbeitung wird in einem zukünftigen Paper veröffentlicht.
Effectiveness of non-pharmacological therapies for chronic pain in people with autoimmune diseases in Africa: A protocol for a systematic review and meta-analysis
Authors: Gebremeskel Gebreamlak Gebremedhn , Haile Teklehaimanot Gereziher , Gebrewahd Gebremeskel Tukue , Hailay Abrha , Aberhe Woldu , Mebrahtom Guesh , Zereabruk Kidane , Negash Assefa Iyasu , Gebrekidan Hailemikael , Tadesse Degena Bahrey 
Published: July 2024

Background
Autoimmune diseases affect 5–10% of the global population and cause chronic pain and impaired functionality. Chronic pain management involves pharmacological and non-pharmacological interventions, with non-pharmacological options gaining attention as safe, effective, and cost-effective alternatives. However, further research is needed to determine the effectiveness of these therapies in African patients with autoimmune diseases, as existing evidence varies.

Methods
This review protocol has been registered in the International Prospective Register of Systematic Reviews (PROSPERO, CRD42023449896). Electronic databases (PubMed, Africa Index Medicus, Cochrane Library, CINAHL, PsycINFO, and Web of Science) will be used for searching published articles. The study will use R for data synthesis, employing a random-effects meta-analysis approach to calculate pooled effect sizes, assess heterogeneity using the I2 statistic, and evaluate publication bias. In conclusion, this protocol aims to fill the knowledge gap on non-pharmacological therapies for chronic pain in patients with autoimmune diseases in Africa. It will potentially enhance evidence-based decision-making to improve pain management and, hence, the quality of life of people with autoimmune diseases in Africa.
Perception of defecation intent: applied methods and technology trends
Authors: Tang Yi , Shi Ping , Yu Hongliu 
Published: July 2024

Abstract
The aging population has led to a widening gap between the supply and demand for defecation care. To address this issue, the development of defecation care devices is the most direct and effective solution. Pre-defecation care devices offer a more personalized and comfortable alternative to the conventional post-defecation care devices currently available on the market. Furthermore, they facilitate greater patient involvement in the care process. Real-time monitoring and accurate identification of defecation intention are key technologies in the development of pre-defecation nursing devices. Automatic and accurate online monitoring of defecation intention can provide accurate early warning information for differentiated defecation assistance and cleansing care, effectively reducing nursing workload and improving patients’ quality of life. However, there are relatively few studies on real-time monitoring and accurate identification of defecation intention. This review summarizes the existing defecation intention sensing technologies and their monitoring principles and research status, and explores the potential development direction of defecation intention sensing systems by comparing the characteristics and application conditions of various sensing technologies, which provides a direction for perception strategies for future defecation intention monitoring and early warning research.
Ethnic Minority Students’ English Learning Agency: An Activity Theory Perspective
Authors: Zhu Xiaohui , Duan Yangyang 
Published: July 2024

Abstract
Recent years have witnessed a growing body of research on the English learning of ethnic minority students in China, yet little is known as to how these students enact their agency to address the challenges they encounter in learning English. Through the lens of activity theory, this qualitative case study explored the manifestations and influencing factors of English learning agency of four first-year Uyghur university students. Data were collected through the students’ journals, interviews, and documents, supplemented by the interview data from their teachers. The findings revealed that Uyghur students’ English learning agency was manifested by reflecting on the gap btween themselves and their Han classmates and adjusting their English learning methods; adapting to the mode of all-English teaching and the rule of English presentation; using tools such as the Mandarin Chinese, English learning apps and the Internet; and seeking help from teachers, peers and other community members. The study also found that Uyghur students’ agency was influenced by factors such as language proficiency, motivation, and personal learning experiences. Additionally, preferential policies of the state and the school, help from teachers and peers, and emotional support from family members also had an impact on their English learning agency. This study provides implications for the English teaching of ethnic minority students at universities.
Typology of solutions addressing diagnostic disparities: gaps and opportunities
Authors: Dukhanin Vadim , Wiegand Aaron A. , Sheikh Taharat , Jajodia Anushka , McDonald Kathryn M. 
Published: July 2024

Abstract

Objectives
Diagnostic disparities are preventable differences in diagnostic errors or opportunities to achieve diagnostic excellence. There is a need to summarize solutions with explicit considerations for addressing diagnostic disparities. We aimed to describe potential solutions to diagnostic disparities, organize them into an action-oriented typology with illustrative examples, and characterize these solutions to identify gaps for their further development.

Methods
During four human-centered design workshops composed of diverse expertise, participants ideated and clarified potential solutions to diagnostic disparities and were supported by environmental literature scan inputs. Nineteen individual semi-structured interviews with workshop participants validated identified solution examples and solution type characterizations, refining the typology.

Results
Our typology organizes 21 various types of potential diagnostic disparities solutions into four primary expertise categories needed for implementation: healthcare systems’ internal expertise, educator-, multidisciplinary patient safety researcher-, and health IT-expertise. We provide descriptions of potential solution types ideated as focused on disparities and compare those to existing examples. Six types were characterized as having diagnostic-disparity-focused examples, five as having diagnostic-focused examples, and 10 as only having general healthcare examples. Only three solution types had widespread implementation. Twelve had implementation on limited scope, and six were mostly hypothetical. We describe gaps that inform the progress needed for each of the suggested solution types to specifically address diagnostic disparities and be suitable for the implementation in routine practice.

Conclusions
Numerous opportunities exist to tailor existing solutions and promote their implementation. Likely enablers include new perspectives, more evidence, multidisciplinary collaborations, system redesign, meaningful patient engagement, and action-oriented coalitions.
A New Interview Tool for the Investigation into the Experiences of Spiritual Family within Church Communities
Authors: Bent Jessica Catherine 
Published: July 2024

Abstract
Among the different images of community, some groups understand themselves in terms of family. This article explores the concept of found family within an ecclesial community. Braithwaite et al.’s four-part typology of voluntary kin provided the grounding for my new interview tool: The Experiences of the Church as Family research tool. This tool can aid in the exploration of church members’ experiences and desires for familial ties within their ecclesial communities. In this article, I outline the tool’s development, provide an example of its application, and present possibilities for future research in congregational contexts in addition to the tool’s potential use in ministry.
Anthropologische Wende in der katholischen Religionspädagogik?
Authors: Herbst Jan-Hendrik 
Published: July 2024

Abstract
In the following article, I address the question of whether an anthropological shift has taken place in Catholic religious education after the Second Vatican Council. Based on the special case of political religious education/catechesis of liberation I exemplify such a shift by means of three exemplary “crystallization points”: The International Catechetical Study Week in Medellín, the European Catechetical Equips (Équipe Européenne de Catéchèse), and the German-Italian exchange meetings. Through these case studies, I illustrate transnational processes of reception and internationalization of religious education.
Recent Trends of Practical Theology in Finland
Authors: Räsänen Antti , Knuutila Jyrki 
Published: July 2024

Abstract
This paper explores historical and recent developments in Finnish Practical Theology and Religious Education. It reconstructs the operating environment under which PT and RE exist in Finland, i. e. its political, economic, and cultural circumstances. To this end, the authors highlight developments such as the transition from a rural-centric to an urban society, the impact of political left-wing ideology, and the impact of Finland’s joining the European Union. Through an analysis of dissertation research at Helsinki University, the paper provides an overview of current topics of research in Finnish PT. The authors concluds with insights into likely future developments in the 21st century.
Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction
Authors: Xia Yongli , Wei Kun , Jiang Lingli , Zou Dongbo , Yang Yuting , Wu Song , Hu Fei , Ma Yuan 
Published: July 2024

Abstract
Acute cerebral infarction (ACI) is a lethal disease whose early diagnosis is critical for treatment. microRNA (miR)-19a targets CC chemokine ligand 20 (CCL20) in myocardial infarction. We investigated the expression patterns of serum miR-19a and CCL20 of ACI patients and assessed their clinical values. Serum samples of 50 healthy subjects and110 ACI patients were collected. Serum levels of miR-19a, CCL20 mRNA, and biochemical indexes were assessed. miR-19a downstream target gene and the binding relationship between miR-19a and CCL20 were predicted and verified. miR-19a and CCL20 mRNA were subjected to correlation and diagnostic efficiency analysis. miR-19a was poorly expressed in the serum of ACI patients, especially in patients with unstable plaque and large infarction. tumor necrosis factor-α, low-density lipoprotein, and platelet/lymphocyte ratio negatively correlated with serum miR-19a level and positively correlated with CCL20. Dual-luciferase assay revealed that miR-19a could negatively regulate CCL20 expression. CCL20 was highly expressed in the serum of ACI patients. The area under receiver-operating characteristic curve of miR-19a combined with CCL20 was 0.9741 (98.00% specificity, 90.91% sensitivity), higher than their single diagnosis. Collectively, miR-19a had high diagnostic value for ACI and could target to restrain CCL20. The combination of miR-19a and CCL20 improved diagnostic value for ACI.
Study on cavitation and pulsation characteristics of a novel rotor-radial groove hydrodynamic cavitation reactor
Authors: Zhang Deman , Deng Peng , Hou Ruijie , Song Yongxing , Liu Jingting , Zhang Weibin 
Published: July 2024

Abstract
Hydrodynamic cavitation is widely used in many fields such as water treatment, impact rock breaking, and food preparation. The performance of hydrodynamic cavitation is closely related to its internal flow field. In the present study, cavitation flow field was analyzed by computational fluid dynamics in the reactor. The cavitation performance of the rotor is evaluated under different operating conditions. The time frequency distribution of pressure pulsation is studied. The pressure increases at the connection point between the local low-pressure area and the mainstream low-pressure area. Cavitation bubbles collapsed at the tail end of the cavity to form a local void area. The blade frequency amplitude of pressure pulsation shows the significant periodic change. The blade frequency amplitude decreases along the flow direction. The effect of the fluid outlet led to the increase in the second-order harmonic frequency amplitude. The research results could provide theoretical support for the research of cavitation mechanism of cavitation equipment.
Situasi Masalah Kesehatan Penyakit Menular di Kabupaten Cirebon
Authors: Masruroh Masruroh , Sudaryo Mondastri Korib , Nurlina Ade 
Published: July 2024

Data kesehatan di Kabupaten Cirebon menunjukkan bahwa masalah kesehatan di Kabupaten Cirebon didominasi oleh penyakit menular. Penelitian ini bertujuan untuk mengidentifikasi masalah penyakit menular dan menetapkan urutan prioritas masalah penyakit menular di Kabupaten Cirebon pada tahun 2020. Metode yang digunakan adalah metode deskriptif dengan pendekatan kuantitatif. Data sekunder dari laporan kesehatan di Dinas Kesehatan Kabupaten Cirebon dianalisis untuk mengidentifikasi masalah penyakit menular yang ada. Penentuan urutan prioritas masalah menggunakan metode PAHO Adapted Hanlon melalui suatu pembobotan yang melibatkan partisipasi pemegang kebijakan internal. Penelitian dilakukan pada Desember 2021 – April 2022. Berdasarkan identifikasi masalah penyakit menular di Kabupaten Cirebon terdapat masalah penyakit menular di Kabupaten Cirebon yaitu DBD, Tuberkulosis, Kusta, Diare, Pneumonia, dan Campak. Diperoleh 3 urutan teratas prioritas masalah penyakit menular di Kabupaten Cirebon yaitu Diare (BPR: 29,40), Tuberkulosis (BPR: 28.99), dan DBD (BPR: 27,13). Diare merupakan masalah penyakit menular dengan urutan prioritas pertama di Kabupaten Cirebon yang diperoleh dari hasil skoring menggunakan metode PAHO adapted Hanlon.
Gambaran Kondisi Fasilitas Sanitasi Lingkungan Pasar Tradisional di Kota Semarang Tahun 2022
Authors: Rizki Herwianti Chyntia Olyvia , Wijayanti Yuni 
Published: July 2024

Abstrak
Pasar merupakan tempat umum dimana dapat menjadi penyebab terjadinya penularan penyakit. Tujuan penelitian ini untuk mengetahui gambaran kondisi fasilitas sanitasi lingkungan pasar tradisional di Kota Semarang. Jenis penelitian ini adalah penelitian deskriptif kuantitatif. Penelitian dilaksanakan pada bulan September dan November tahun 2022. Jumlah sampel yaitu 30 pasar yang ditentukan menggunakan cluster random sampling dan teori Cohen (2007). Data dianalisis secara univariat. Hasil penelitian diperoleh pasar tradisional di Kota Semarang yang tidak memenuhi syarat kesehatan berdasarkan Permenkes Nomor 17 Tahun 2020 Tentang Pasar Sehat dan Standar Nasional Indonesia (SNI) 8152:2021 Tentang Pasar Rakyat yaitu air untuk kebutuhan higiene dan sanitasi (60%), kamar mandi dan toilet (53%), pengelolaan sampah (13%), SPAL (3%), IPAL (100%), tempat cuci tangan (40%), pengendalian vektor dan binatang pembawa penyakit (87%), kualitas makanan dan bahan pangan (80%), dan desinfeksi pasar (0%). Seluruh pasar tradisional harus menerapkan fasilitas sanitasi sebagai upaya pencegahan penyebaran penyakit di lingkungan pasar.

Abstract
The market is a public place where it can be a cause of disease transmission. This study aims to describe the condition of environmental sanitation facilities in traditional markets in the city of Semarang. This type of research is a quantitative descriptive research. This research was conducted in September and November 2022. The number of samples was 30 markets which were determined using cluster random sampling and Cohen's theory (2007). Data were analyzed univariately. The results of the study obtained traditional markets in Semarang City that did not meet health requirements based on Permenkes Number 17 of 2020 concerning Healthy Markets and Indonesian National Standards (SNI) 8152:2021 Concerning People's Markets, namely water for hygiene and sanitation needs (60%), bathrooms and toilets (53%), waste management (13%), SPAL (3%), IPAL (100%), hand washing facilities (40%), vector control and disease-carrying animals (87%), quality of food and ingredients ( 80%), and market disinfection (0%). All traditional markets must implement sanitation facilities as an effort to prevent the spread of disease in the market environment.