bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategi Pembelajaran Efektif Bagi Siswa Tunagrahita di SLB Fajar Harapan
Authors: Sutanto Tiara Putri , Christiana Elisabeth 
Published: July 2024

Anak berkebutuhan khusus adalah anak yang lahir dengan kebutuhan khusus yang berbeda dengan individu lainnya maka dari itu mereka juga membutuhkan pelayanan yang khusus pula. Anak yang memiliki kemampuan intelektual dan kognitif dibawah rata-rata dibandingkan orang pada umumnya maka ia adalah penyandang tunagrahita. Anak tunagrahita cenderung sulit untuk berpikir secara logis dan memahami aturan sosial, artikel ini bertujuan untuk mengidentifikasi strategi pembelajaran yang efektif bagi anak penyandang tunagrahita yang dilakukan oleh SLB Fajar Harapan Surabaya. Metode yang digunakan yaitu penelitian lapangan yang bersifat deskriptif. Subjek dalam penelitian ini adalah siswa tunagrahita dan guru di SLB Fajar Harapan Surabaya. Pengumpulan data dilakukan dengan menggunakan teknik observasi, wawancara dan dokumentasi. Hasil penelitian ini menyimpulkan bahwa pemberian materi pembelajaran siswa tunagrahita berbeda dengan jenis siswa berkebutuhan khusus lainnya. Dalam pelaksanaannya, guru di SLB Fajar Harapan Surabaya melakukan pemberian materi yang terdapat di kurikulum secara bertahap kepada siswa penyandang tunagrahita.
Evaluasi Program PAUD Holistik Integratif dengan Model CIPP di PAUD Eunike Lobalain
Authors: Logo Radja Petrus , D. Saefatu Irony , Lopo Retno , Tse Esterina 
Published: July 2024

Tujuan dari penelitian ini adalah untuk mengetahui sejauhmana penerapan program layanan PAUD HI pada Pendidikan Anak Usia Dini Eunike Lobalain di Kabupaten Rote Ndao serta untuk mengetahui hasil evaluasi program layanan PAUD HI dengan model CIPP di PAUD Eunike Lobalain Kabupaten Rote Ndao. Jenis penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan deskriptif. Sedangkan metode yang digunakan adalah metode evaluasi. Teknik pengumpulan data berupa wawancara, observasi dan dokumentasi. Hasil penelitian: 1) Evaluasi Konteks : Adanya pemahaman yang baik tentang latar belakang pelaksanaan program PAUD HI, kebutuhan, tujuan, dan sasaran program PAUD HI 2) Evaluasi Input : Program layanan PAUD HI pada PAUD Eunike didukung dengan adanya sumber daya yang memadai seperti kerjasama dengan berbagai pihak terkait program PAUD HI, serta Rencana Program dalam menanggulangi kendala-kendala yang ditemui pada pelaksanaan program PAUD HI. 3) Evaluasi Proses: dalam prosesnya Program layanan PAUD HI pada PAUD Eunike ini telah terlaksana dengan baik dan sesuai dengan yang telah diprogramkan seperti implementasi kerjasama dengan berbagai pihak, serta pengembangan program yang disesuaikan dengan kebutuhan. 4) Evaluasi Produk: Produk atau luaran, keuntungan serta dampak yang dihasilkan dari Program Layanan PAUD HI pada PAUD Eunike meliputi layanan pendidikan, kesehatan, Gizi, perlindungan dan pengasuhan.
Desain Instruksional Eksperimen Sains Sederhana Pada Anak Usia Dini
Authors: Candra Destiyanti Ika 
Published: July 2024

Eksperimen sains untuk anak usia dini menjadi media dalam melatih anak mengembangkan ide dan kreativitas nya di sekolah. Desain Instruksional dengan konteks eksperimen sains di kelas paud akan melatih daya kritis anak terutama dalam pemecahan masalah meskipun melatih anak belajar sambil bermain namun eksperimen sains ini dapat melatih siswa dalam daya nalar dan penemuan makna. Tujuan Riset ini untuk mengetahui desain instruksional ekperimen sains di kelas PAUD. Dengan menggunakan metode penelitian Kualitatif, Dua Puluh siswa kelas B dengan rentan usia 5 hingga 6 tahun berpartisipasi dalam proyek eksperimen sains sederhana bermain gelembung gajah Hasil penelitian menunjukkan bahwa proses eksperimen sains sederhana membantu siswa untuk terlibat secara aktif dalam memilih bahan eksperimen menguji dan menganalisis bahan bahan eksperimen sains sederhana dan menghasilkan ide kreatif untuk mengenal tema gelembung dan bermain dari bahan eksperimen sains sederhana. Implikasi pedagogis dari penelitian ini adalah bahwa media pembelajaran eksperimen sains sederhana mendorong keterlibatan siswa dalam proses mengembangkan bernalar kritis dan meningkatkan kreativitas siswa tingkat PAUD memahami materi perubahan warna maupun reaksi kimia.
Analisis Manajemen Pola Asuh Terhadap Kemandirian Anak Usia Dini
Authors: Sufi Wasiah , Efastri Sean Marta 
Published: July 2024

Penelitian ini dilakukan dengan tujuan untuk mengetahui Gambaran pola asuh terhadap kemandirian anak usia dini di TK Amaliyah Perawang. Jenis penelitian yang peneliti gunakan adalah penelitian kuantitatif deskriptif. Berdasarkan hasil penelitian yang telah dilakukan, diketahui Manajeman Pola Asuh Terhadap Kemandirian Anak termasuk kategori baik. Hasil persentase pernyataan faktor Anak mampu berinteraksi adalah sebanyak 69,58% responden dengan kategori S, hasil persentase nomor 2 Anak mulai mematuhi aturan adalah sebanyak 69,72% reponden dengan kategori S, hasil persentase pernyataan nomor 3 yaitu Anak dapat mengendalikan emosi adalah sebanyak 75% responden dengan kategori S, hasil persentase pernyataan nomor 4 yaitu Anak dapat menunjukkan rasa percaya diri adalah sebanyak 71,39% responden dengan kategori S, hasil persentase nomor 5 yaitu Dapat menjaga diri sendiri adalah sebanyak 67,1%. Hasil persentase tersebut dapat dinyatakan bahwa Analisis Manajemen Pola Asuh Terhadap Kemandirian Anak Usia Dini Di Tk Amaliyah Perawang yang memiliki pengaruh tertinggi ialah Anak dapat mengendalikan emosi yang berada dalam kategori S dengan tingkat 75%.
Desain Multi Amfibi Ship Sebagai Sarana Evakuasi Tanggap Darurat Bencana Alam Banjir
Authors: Risdianto Anauta Lungiding Angga , Prasetyo Taufan , Hadiwijaya Lukman 
Published: July 2024

Indonesia merupakan negara tropis namun, setiap tahunya mengalami pengurangan luas hutan sebesar 0,5% dari luas daratan. Kondisi tersebut menjadi penyebab bencana banjir serta curah hujan yang tinggi mengakibatkan air cepat memenuhi bendungan. Dari permasalahan yang ada perlu dilakukan modifikasi sebagai sarana evakuasi yang evektif. Pada penelitian ini kami menggunakan metode Reserch and Development (R&D) dengan memodifikasi antara kapal dan kendaraan darat. Inovasi yang dilakukan yaitu Multi Amfibi Boat. Hasil penelitian yaitu desain konseptual sebagai gambaran untuk dilakukan perencanaan pembuatan secara 1:1. Ukuran utama desain dengan panjang 3 m; lebar 1,2 m; tinggi 1,1 m; dan sarat 0,5 m. Pemilihan ukuran dilakukan untuk memastikan sarana ini dapat digunakan pada gang kecil sehingga memudahkan dan pemempercepat saat evakuasi banjir jika terjadi di daerah perkotaan atau daerah padat penduduk.
Identifikasi Tingkat Kematangan Buah Carica dalam Pengolahan Citra Digital dengan Menggunakan Metode Transformasi Ruang Warna HSI
Authors: Maula M. Tsaqif Daniyal , Santoso Firman , Ghofur Abd. 
Published: July 2024

Buah carica merupakan buah yang jarang ditemui, buah ini hanya terdapat di pegunungan Dieng yaitu Kawasan Wonosobo-Banjarnegara. Penelitian ini bertujuan untuk melakukan identifikasi tingkat kematangan buah carica menggunakan transformasi ruang warna HSI dilakukan guna untuk memperoleh informasi yang lebih baik tentang tingkat kematangan buah dalam melakukan pemilihan buah yang akan diolah. Pada proses identifikasi kematangan buah carica menggunakan 90 dataset. Adapun 90 dataset ini terbagi dari 3 kategori yaitu, 30 matang, 30 mengkal, dan 30 mentah. Kemudian, dari 90 dataset dibagi menjadi 30 data training dan 60 data testing. Hasil dari identifikasi menunjukan 57 benar dari 60 dataset testing dengan menunjukan akurasi 95%.
Pengembangan Sistem Deteksi Penyakit Tanaman Tomat Melalui Citra Daun dengan Metode You Only Look Once (YOLO) Berbasis Android
Authors: Erwanto Bagus , Pradana Afu Ichsan , Hartanti Dwi 
Published: July 2024

Pertanian memiliki peran penting dalam ekonomi Indonesia, khususnya sub-sektor hortikultura seperti produksi buah dan sayuran. Budidaya tomat (Lycopersicum esculentum Mill) menjadi salah satu komoditas unggulan, namun serangan penyakit pada daun tomat menjadi tantangan utama yang dapat mengurangi hasil panen. Berbagai penelitian telah menyoroti kebutuhan akan solusi deteksi penyakit tanaman berbasis komputer vision untuk tomat. Penelitian ini fokus pada pengembangan aplikasi deteksi penyakit pada citra daun tomat berbasis Android menggunakan metode YOLO versi 8. Evaluasi model dilakukan menggunakan confusion matrix dan metrik seperti precision, recall, dan mAP.Hasilnya menunjukkan akurasi yang tinggi dalam mengklasifikasikan berbagai penyakit pada daun tomat. Hasil menunjukkan kinerja model yang baik dalam mengklasifikasikan berbagai jenis penyakit pada daun tomat, dengan mAP sebesar 96.6% dan recall sebesar 92.2% untuk seluruh kelas penyakit. Pengujian aplikasi dengan Black box testing menunjukkan kemampuan deteksi yang baik. Aplikasi ini berhasil dikembangkan dan dirilis sebagai "Plantify" di Apkpure.
Variety of genetic defects in GnRH and hypothalamic–pituitary signaling and development in normosmic patients with IHH
Authors: Kałużna Małgorzata , Budny Bartłomiej , Rabijewski Michał , Dubiel Agnieszka , Trofimiuk-Müldner Małgorzata , Szutkowski Kosma , Piotrowski Adam , Wrotkowska Elżbieta , Hubalewska-Dydejczyk Alicja , Ruchała Marek , Ziemnicka Katarzyna 
Published: July 2024

IntroductionNormosmic isolated hypogonadotropic hypogonadism (nIHH) is a clinically and genetically heterogeneous disorder. Deleterious variants in over 50 genes have been implicated in the etiology of IHH, which also indicates a possible role of digenicity and oligogenicity. Both classes of genes controlling GnRH neuron migration/development and hypothalamic/pituitary signaling and development are strongly implicated in nIHH pathogenesis. The study aimed to investigate the genetic background of nIHH and further expand the genotype–phenotype correlation.MethodsA total of 67 patients with nIHH were enrolled in the study. NGS technology and a 38-gene panel were applied.ResultsCausative defects regarded as at least one pathogenic/likely pathogenic (P/LP) variant were found in 23 patients (34%). For another 30 individuals, variants of unknown significance (VUS) or benign (B) were evidenced (45%). The most frequently mutated genes presenting P/LP alterations were GNRHR (n = 5), TACR3 (n = 3), and CHD7, FGFR1, NSMF, BMP4, and NROB1 (n = 2 each). Monogenic variants with solid clinical significance (P/LP) were observed in 15% of subjects, whereas oligogenic defects were detected in 19% of patients. Regarding recurrence, 17 novel pathogenic variants affecting 10 genes were identified for 17 patients. The most recurrent pathogenic change was GNRHR:p.Arg139His, detected in four unrelated subjects. Another interesting observation is that P/LP defects were found more often in genes related to hypothalamic–pituitary pathways than those related to GnRH.ConclusionsThe growing importance of the neuroendocrine pathway and related genes is drawing increasing attention to nIHH. However, the underestimated potential of VUS variants in IHH etiology, particularly those presenting recurrence, should be further elucidated.
Bioinformatics analysis of the association between obesity and gastric cancer
Authors: Ma Xiaole , Cui Miao , Guo Yuntong 
Published: July 2024

BackgroundObesity and gastric cancer (GC) are prevalent diseases worldwide. In particular, the number of patients with obesity is increasing annually, while the incidence and mortality rates of GC are ranked high. Consequently, these conditions seriously affect the quality of life of individuals. While evidence suggests a strong association between these two conditions, the underlying mechanisms of this comorbidity remain unclear.MethodsWe obtained the gene expression profiles of GSE94752 and GSE54129 from the Gene Expression Omnibus database. To investigate the associated biological processes, pathway enrichment analyses were conducted using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes for the shared differentially expressed genes in obesity and GC. A protein–protein interaction (PPI) network was subsequently established based on the Search Tool for the Retrieval of Interacting Genes (STRING) database, followed by the screening of the core modules and central genes in this network using Cytoscape plug-in MCODE. Furthermore, we scrutinized the co-expression network and the interplay network of transcription factors (TFs), miRNAs, and mRNAs linked to these central genes. Finally, we conducted further analyses using different datasets to validate the significance of the hub genes.ResultsA total of 246 shared differentially expressed genes (209 upregulated and 37 downregulated) were selected for ensuing analyses. Functional analysis emphasized the pivotal role of inflammation and immune-associated pathways in these two diseases. Using the Cytoscape plug-in CytoHubba, nine hub genes were identified, namely, CXCR4, CXCL8, CXCL10, IL6, TNF, CCL4, CXCL2, CD4, and CCL2. IL6 and CCL4 were confirmed as the final hub genes through validation using different datasets. The TF-miRNA-mRNA regulatory network showed that the TFs primarily associated with the hub genes included RELA and NFKB1, while the predominantly associated miRNAs included has-miR-195-5p and has-miR-106a-5p.ConclusionUsing bioinformatics methods, we identified two hub genes from the Gene Expression Omnibus datasets for obesity and GC. In addition, we constructed a network of hub genes, TFs, and miRNAs, and identified the major related TFs and miRNAs. These factors may be involved in the common molecular mechanisms of obesity and GC.
Effects of fucoidan and synbiotics supplementation during bismuth quadruple therapy of Helicobacter pylori infection on gut microbial homeostasis: an open-label, randomized clinical trial
Authors: Wang Huifen , Wei Wei , Liu Fang , Wang Miao , Zhang Yanli , Du Shiyu 
Published: July 2024

BackgroundThe eradication regimen for Helicobacter pylori (H. pylori) infection can induce gut dysbiosis. In this open-label, prospective, and randomized clinical trial, we aimed to assess the effects of fucoidan supplementation on the eradication rate and gut microbial homeostasis in the context of quadruple therapy, as well as to investigate the combined effects of fucoidan and synbiotics supplementations.MethodsEighty patients with H. pylori infection were enrolled and randomly assigned to one of four treatment groups: the QT (a 2-week quadruple therapy alone), QF (quadruple therapy plus a 6-week fucoidan supplementation), QS (quadruple therapy plus a 6-week synbiotics supplementation), and QFS (quadruple therapy with a 6-week fucoidan and synbiotics supplementation), with 20 patients in each group. The QT regimen included rabeprazole, minocycline, amoxicillin, and bismuth potassium citrate. The synbiotics supplementation contained three strains of Bifidobacterium, three strains of Lactobacillus, along with three types of dietary fiber. All of the patients underwent 13C-urea breath test (13C-UBT) at baseline and at the end of the 6th week after the initiation of the interventions. Fresh fecal samples were collected at baseline and at the end of the 6th week for gut microbiota analysis via 16S rRNA gene sequencing.ResultsThe eradication rates among the four groups showed no significant difference. In the QT group, a significant reduction in α-diversity of gut microbiota diversity and a substantial shift in microbial composition were observed, particularly an increase in Escherichia-Shigella and a decrease in the abundance of genera from the Lachnospiraceae and Ruminococcaceae families. The Simpson index was significantly higher in the QF group than in the QT group. Neither the QS nor QFS groups exhibited significant changes in α-diversity or β-diversity. The QFS group was the only one that did not show a significant increase in the relative abundance of Escherichia-Shigella, and the relative abundance of Klebsiella significantly decreased in this group.ConclusionThe current study provided supporting evidence for the positive role of fucoidan and synbiotics supplementation in the gut microbiota. The combined use of fucoidan and synbioticss might be a promising adjuvant regimen to mitigate gut dysbiosis during H. pylori eradication therapy.
Functional and perceptive differences between conventional and advanced ankle foot orthoses in community ambulators post-limb trauma: the injuries managed with advanced bracing of the lower extremity (IM ABLE) study
Authors: Highsmith M. Jason , Miro Rebecca M. , Kartel Michael , Ramrattan Anita , Courtade Angela , Heckman Jeffrey T. , Phillips Samuel L. , Wurdeman Shane R. , DiBello Thomas V. , England Dwiesha L. , Stevens Phillip M. , Campbell James H. , Hyre Michael J. , Maikos Jason T. , Hill Owen T. , Carey Stephanie L. 
Published: July 2024

IntroductionMany military service members and civilians suffer from lower extremity trauma. Despite recent advancements in lower limb bracing technology, it remains unclear whether these newer advanced braces offer improved comfort and functionality compared to conventional options. The IDEO (Intrepid Dynamic Exoskeletal Orthosis), a type of “advanced” orthosis was developed to assist in maintaining high functional performance in patients who have experienced high-energy lower extremity trauma and underwent limb salvage surgeries.MethodsA cross-sector multi-site initiative was completed to study the efficacy of advanced ankle foot orthoses (AFO) for lower limb trauma and injury compared to a conventional AFO. Following fitting, training, and accommodation, the subjects were assessed in each AFO system for mobility, self-reported function, safety and pain, and preference.ResultsThey preferred the advanced over the conventional AFO and the mobility and exertion perception improved with the advanced AFO with no difference in pain or overall health status scores.DiscussionThus, an advanced AFO is an option for trauma affecting the lower limb. Long-term studies are required to better understand the accommodation and learning process of using an advanced AFO.
Toward an innovation radar for cultivated meat: exploring process technologies for cultivated meat and claims about their social impacts
Authors: Woelken Lisa , Weckowska Dagmara M. , Dreher Carsten , Rauh Cornelia 
Published: July 2024

IntroductionCultivated meat has received growing attention since claims were made that cultivated meat can be produced more ethically and sustainably than the current meat production. However, there are still major challenges in the development of cell lines, scaffolding, growth media, and bioprocess, which need to be overcome to reach industrial production levels. Numerous technological innovations have been proposed to overcome these challenges but they have rarely been evaluated with regard to their social sustainability. Consequently, it remains unclear if and how cultivated meat would contribute towards creating inclusive food systems.MethodsTo bring more clarity, the study identifies different technological solutions that are used or developed for production of cultivated meat and identifies the positive and negative claims about the expected contributions of these technological solutions to social inclusion in food systems, using evidence from the literature review and 11 expert interviews. An innovation radar for cultivated meat is proposed to visualise the variety of technological innovations and the claims about their expected contributions to social sustainability.ResultsThe technologies in the areas cell line development, scaffolding, growth media, and bioprocess are expected to have an impact on inclusion in consumption of cultivated meat. Some cell innovations are expected to raise cognitive barriers due to complex technologies that might be difficult for the consumer to understand. Cultural barriers are expected to be raised by cell innovation entailing genetic engineering and medium innovation using FBS or animal components, which is considered to harm animals. Further, regulatory barriers are expected in the EU if genetic modification is used in the production process, which concerns the areas cells, media, and scaffolding. The innovations for scaffolds are expected to mainly lower cost and cultural barriers since most technologies are already used in the food industry. Bioprocess innovations promise to lower cost barriers, however it must be considered, that most of the collected data for innovations in the bioprocess domain are based on assumptions.DiscussionThe study concludes that at this point in time, the most socially sustainable approach to cultivated meat production is not obvious. Under the current technological state of the art, it is not thinkable that production and consumption of cultivated meat could be socially inclusive. As it remains poorly understood if technologies for cultivated meat production could raise or lower barriers to inclusive consumption and production, further research is needed.
Bacterial Contamination and Antimicrobial Resistance in Two-Spotted (Gryllus bimaculatus) and House (Acheta domesticus) Cricket Rearing and Harvesting Processes
Authors: Mitchaothai Jamlong , Grabowski Nils T. , Lertpatarakomol Rachakris , Trairatapiwan Tassanee , Lukkananukool Achara 
Published: July 2024

Food safety for cricket production is a crucial factor in producing edible crickets with safety for consumers and sustainability for two-spotted (Gryllus bimaculatus) as well as house (Acheta domesticus) cricket production. This study was conducted by simultaneously rearing two cricket species, comprising two-spotted crickets (G. bimaculatus) and house crickets (A. domesticus). A total of 16 rearing crates were used for the present study, which were allocated into 8 rearing crates for each studied cricket species, including paper egg cartons. Cricket eggs were incubated in the rearing crates. Once the crickets hatched, tap water and powdered feed were provided ad libitum throughout the experiment. At the end of this study (35 and 42 days for the two-spotted and house crickets, respectively), all crickets were harvested, rinsed in tap water, and boiled in water for 5 min. During the rearing and harvesting processes, samples were collected from various potential contamination points for bacteria, including E. coli and Salmonella spp. There were samples of the initial input (feed, drinking water, and staff hands), rearing environment (water pipe, crate wall, living cartons, frass, and cricket surface), and harvesting crickets (harvested, washed, and boiled crickets), with a 2-week sampling interval, except for the last round of sampling for the two-spotted crickets. Subsequently, all samples were submitted to isolate and identify contaminated bacteria. The samples from the last round of sampling for both kinds of crickets were submitted to quantify the level of contamination for E. coli and Salmonella spp., including antimicrobial resistance by the disk diffusion method for the positive isolate. The results showed that bacterial contamination was found in the rearing of both cricket species, primarily involving Klebsiella spp. and Enterobacter spp., mainly found in prepared drinking water and the water pipes of drinking water supply equipment, which are potential sources of contamination with cricket frass. E. coli was found in 4.8% and 4.3% of the two-spotted and house crickets, respectively, while no presence of Salmonella spp. was detected in any submitted samples. The quantification of E. coli and Salmonella spp. indicated E. coli contamination near the water pipe and the frass of two-spotted crickets, but Salmonella spp. was undetectable in both two-spotted and house crickets. The antimicrobial resistance of isolated E. coli mainly involved penicillin G, amoxicillin, ampicillin, erythromycin, lincomycin, and tiamulin. Thus, good farm management with proper sanitation practices (such as cleaning and keeping the environment dry), as well as boiling crickets during the harvesting process, may help ensure the safety of edible cricket production.