bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Palladium Mediated C—H Bond Activation of Thiosemicarbazones: Catalytic Application of Organopalladium Complexes in C—C and C—N Coupling Reactions.
Authors: Paul Piyali , Sengupta Poulami , Bhattacharya Samaresh 
Published: May 2013

AbstractA novel palladium thiosemicarbazone complex is prepared and efficiently applied as a catalyst for the arylation of amines (IV) and (VII) with halobenzenes (V).
ChemInform Abstract: Practical One‐Pot Sequence for the Asymmetric Synthesis of 1,2‐Diols from Primary Alcohols.
Authors: Hermange Philippe , Portalier Francois , Thomassigny Christine , Greck Christine 
Published: May 2013

AbstractA convenient three‐step approach is developed for the synthesis of enantioenriched monoprotected 1,2‐diols.
ChemInform Abstract: Iodine‐Mediated α‐Sulfonyloxylation of Alkyl Aryl Ketones with Oxone® and Sulfonic Acids.
Authors: Kikui Hiroki , Moriyama Katsuhiko , Togo Hideo 
Published: May 2013

AbstractVarious title compounds, important precursors of a broad spectrum of heteroaromatics, are prepared with TosOH or MesOH as the sulfonyl agent.
ChemInform Abstract: Nickel‐Catalyzed Cross Couplings of Benzylic Ammonium Salts and Boronic Acids: Stereospecific Formation of Diarylethanes via C—N Bond Activation.
Authors: Maity Prantik , Shacklady‐McAtee Danielle M. , Yap Glenn P. A. , Sirianni Eric R. , Watson Mary P. 
Published: May 2013

AbstractA wide range of diaryl methanes is prepared tolerating many functional groups and heterocyclic substituents [cf.
ChemInform Abstract: Cerium Ammonium Nitrate‐Mediated the Oxidative Dimerization of p‐Alkenylphenols: A New Synthesis of Substituted (.+‐.)‐trans‐Dihydrobenzofurans.
Authors: Chen Po‐Yuan , Wu Yi‐Hua , Hsu Mon‐Huei , Wang Tzu‐Pin , Wang Eng‐Chi 
Published: May 2013

AbstractAlkenylphenols (I) undergo a diastereoselective oxidative dimerization to generate 2,3‐disubstituted dihydrobenzofurans like conocarpin (IIb), licarin A (IId) and congeners.This radical dimerization is found to be reversible and therefore sensitive to the concentration of CAN and the reaction time.
ChemInform Abstract: Site‐Selective Multicomponent Synthesis of Densely Substituted 2‐Oxo Dihydropyrroles Catalyzed by Clean, Reusable, and Heterogeneous TiO2 Nanopowder.
Authors: Rana Sunil , Brown Mike , Dutta Arghya , Bhaumik Asim , Mukhopadhyay Chhanda 
Published: May 2013

AbstractAn environmentally benign process is developed for the reaction of diesters (I) or (IX) with aldehydes and 2 equiv.
ChemInform Abstract: Facile Access to 3‐Acylindoles Through Palladium‐Catalyzed Addition of Indoles to Nitriles: The One‐Pot Synthesis of Indenoindolones.
Authors: Ma Yuanhong , You Jingsong , Song Feijie 
Published: May 2013

AbstractSynthesis of indolylarylketones proceeds with high selectivity and for a wide substrate scope by the presented operationally simple procedure.
ChemInform Abstract: Cu(OTf)2‐Catalyzed Synthesis of 2,3‐Disubstituted Indoles and 2,4,5‐Trisubstituted Pyrroles from α‐Diazoketones.
Authors: Reddy B. v. Subba , Reddy M. Ramana , Rao Y. Gopal , Yadav J. S. , Sridhar B. 
Published: May 2013

AbstractPractical application of this method is demonstrated by the total synthesis of homofascaplysin C (IX).
ChemInform Abstract: Novel Protocol for the Synthesis of Octahydropyrano‐ and Thiopyrano[4,3‐a]carbazole Derivatives via Prins/Friedel—Crafts Cyclization.
Authors: Reddy B. V. Subba , Reddy P. Sivaramakrishna , Yadav J. S. , Sridhar B. 
Published: May 2013

AbstractCyclization of alcohol (I) or thiol (IV) with aldehydes proceeds under mild conditions to give the title compounds with high diastereoselectivity.
ChemInform Abstract: “One‐Pot” Synthesis of 4‐Substituted 1,5‐Diaryl‐1H‐pyrazole‐3‐carboxylates via Lithium tert‐Butoxide‐Mediated Sterically Hindered Claisen Condensation and Knorr Reaction.
Authors: Jiang Jian‐An , Huang Wei‐Bin , Zhai Jiao‐Jiao , Liu Hong‐Wei , Cai Qi , Xu Liu‐Xin , Wang Wei , Ji Ya‐Fei 
Published: May 2013

AbstractIn some cases besides the desired 1,5‐isomer (IV) an 1,3‐isomer is formed as well, even though in small amounts.
ChemInform Abstract: Chemo‐ and Regioselective 1,3‐Dipolar Cycloaddition of 2‐Diazopropane over 1,4‐Benzoquinone: Synthesis of New Pyrazoloquinones.
Authors: Ben Hamadi Naoufel , Lachheb Jalel , Guerfel Taha , Msaddek Moncef 
Published: May 2013

Abstract1,3‐Dipolar cycloaddition of diazopropane (II) with benzoquinone affords bis‐cycloadducts (IV) and (V) along with minor amounts of mono‐adduct (III).
ChemInform Abstract: Gold(I)‐Catalyzed Aminohalogenation of Fluorinated N′‐Aryl‐N‐propargyl Amidines for the Synthesis of Imidazole Derivatives under Mild Conditions.
Authors: Li Shan , Li Zhengke , Yuan Yafen , Li Yajun , Zhang Lisi , Wu Yongming 
Published: May 2013

AbstractA new procedure for the synthesis of fluorinated imidazole derivatives from propargyl amidines is presented.
ChemInform Abstract: Regioselective Nucleophilic Addition of 3‐Aryl‐5‐difluoromethyl‐isoxazoles to Aldehydes.
Authors: Yang Xueyan , Fang Xiang , Zhang Dong , Yu Yanlin , Zhang Zhengdong , Wu Fanhong 
Published: May 2013

AbstractThe direction of the title reaction depends on the base employed and provides regioselective access to side chain alkylated products (IV) or ring‐alkylated products (V).
ChemInform Abstract: Visible Light Driven Synthesis of 2‐Substituted Benzothiazoles Using CdS Nanosphere as Heterogenous Recyclable Catalyst.
Authors: Das Sudipto , Samanta Suvendu , Maji Swarup Kumar , Samanta Partha Kumar , Dutta Amit Kumar , Srivastava Divesh N. , Adhikary Bibhutosh , Biswas Papu 
Published: May 2013

AbstractThe mesoporous CdS nanosphere is successfully applied in the preparation of various benzothiazole derivatives bearing aromatic, heteroaromatic or aliphatic residues at C‐2.
ChemInform Abstract: Super Acid Catalyzed Sequential Hydrolysis/Cycloisomerization of o‐(Acetylenic)benzamides under Microwave Condition: Synthesis, Antinociceptive and Antiinflammatory Activity of Substituted Isocoumarins.
Authors: Praveen Chandrasekaran , Dheenkumar P. , Perumal P. T. 
Published: May 2013

AbstractThis is the first direct synthesis of isocoumarins from o‐alkynylbenzamides under super acid conditions.
ChemInform Abstract: Efficient Synthesis and Insecticidal Activity of Novel Pyridin‐3‐yl‐[1,2,4]triazolo[3,4‐b][1,3,4]thiadiazoles.
Authors: Qian Qun , Zhu Yiwen , Zhang Min , Lu Dongliang , Cao Weiguo , Song Liping , Huang Qingchun 
Published: May 2013

Abstract9 Title compounds of type (XI) are prepared and tested for their insecticidal activity.
ChemInform Abstract: I2‐Promoted Direct One‐Pot Synthesis of 2‐Aryl‐3‐(pyridine‐2‐ylamino)imidazo[1,2‐a]pyridines from Aromatic Ketones and 2‐Aminopyridines.
Authors: Fei Zhuan , Zhu Yan‐ping , Liu Mei‐cai , Jia Feng‐cheng , Wu An‐xin 
Published: May 2013

AbstractThe heterocyclic skeleton is readily available in moderate yields without the need for any metal or base catalyst.
ChemInform Abstract: Asymmetric Synthesis of Trifluoromethyl‐Piperidine Based γ‐Amino Acids and of Trifluoromethyl‐Indolizidines.
Authors: Jatoi Wahid Bux , Desiront Agnes , Job Aurelie , Troin Yves , Canet Jean‐Louis 
Published: May 2013

AbstractTitle compounds such as (VII), (X), and (XIV) are prepared in a highly enantio‐enriched form employing as key step an intramolecular Mannich type process, involving an enantiopure aminoketal (I) and oxobutenoate (II) as aldehyde partner.
ChemInform Abstract: Highly Stereoselective Glycosyl‐Chloride‐Mediated Synthesis of 2‐Deoxyglucosides.
Authors: Verma Ved Prakash , Wang Cheng‐Chung 
Published: May 2013

AbstractThe method does not require a 2,3‐O‐conformation restricting group and uses Tol‐S‐Cl/AgOTf as a preactivation system.
Bringing Redox Reactivity to a Redox Inactive Metal Center – E–I (E = C, Si) Bond Cleavage with a Thorium Bis(α‐diimine) Complex
Authors: Mrutu Agnes , Barnes Charles L. , Bart Suzanne C. , Walensky Justin R. 
Published: May 2013

AbstractAs the reactivity of transition‐metal complexes with redox‐active ligands has gained significant attention in recent years, we have begun expanding to the actinides. Here, we report the synthesis, characterization, and reactivity of (MesDABMe)2Th(THF) {1, MesDABMe = [MesNC(Me)=C(Me)NMes]2–, Mes = 2,4,6‐trimethylphenyl, THF = tetrahydrofuran}, which cleaves the C–I bond in CH3I with subsequent Th–I and C–C bond formation to produce (MesDABMe)(MesDAB)ThI {2, MesDAB = [MesN=C(Me)C(Me)2NMes]–}. When 2 is crystallized in acetonitrile, the solvated adduct (MesDABMe)(MesDAB)ThI(NCCH3) (2‐MeCN) is isolated. The reaction of 2 equiv. of 1 with Me3SiI produces (MesDABMe)2ThI (3) and Me3SiSiMe3. In 3, one MesDABMe ligand is now monoanionic and provides an electron to cleave the Si–I bond. This represents a rare example of the reactivity of thorium with a redox‐active ligand.
Coronary drug‐eluting stents: From design optimization to newer strategies
Authors: Sun Daming , Zheng Yiming , Yin Tieying , Tang Chaojun , Yu Qingsong , Wang Guixue 
Published: May 2013

AbstractCompared with early bare‐metal stents, drug‐eluting stents (DESs) are more effective in treating coronary artery diseases, especially in inhibiting restenosis. However, in‐stent restenosis still clinically occurs at a non‐negligible rate. More importantly, delayed endothelialization, inflammation, and hypersensitivity trigger subacute or late adverse events, particularly stent thrombosis, and thereby raise more concerns over the long‐term safety of DESs. These problems are mostly associated with the permanent polymeric materials, non‐optimal therapeutic drugs, and/or metallic stent platforms used in current DES design. It is critically important to further improve and optimize DES design and apply newer strategies for developing next generation DES. These new generation DESs should maintain their clinical efficacy and meanwhile eliminate the long‐term safety concerns. In this review article, the current information on the optimization of DES design was critically reviewed based on DES's basic components, namely, stent platform, restenotic drug, and polymer coating. The available strategies for designing next‐generation DESs were also summarized, ranging from degradable polymer DESs, to polymer‐free DESs, to fully biodegradable DESs. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 1625–1640, 2014.
Hyperactive Transforming Growth Factor-β1 Signaling Potentiates Skeletal Defects in a Neurofibromatosis Type 1 Mouse Model
Authors: Rhodes Steven D , Wu Xiaohua , He Yongzheng , Chen Shi , Yang Hao , Staser Karl W , Wang Jiapeng , Zhang Ping , Jiang Chang , Yokota Hiroki , Dong Ruizhi , Peng Xianghong , Yang Xianlin , Murthy Sreemala , Azhar Mohamad , Mohammad Khalid S , Xu Mingjiang , Guise Theresa A , Yang Feng-Chun 
Published: May 2013

ABSTRACT

Dysregulated transforming growth factor beta (TGF-β) signaling is associated with a spectrum of osseous defects as seen in Loeys-Dietz syndrome, Marfan syndrome, and Camurati-Engelmann disease. Intriguingly, neurofibromatosis type 1 (NF1) patients exhibit many of these characteristic skeletal features, including kyphoscoliosis, osteoporosis, tibial dysplasia, and pseudarthrosis; however, the molecular mechanisms mediating these phenotypes remain unclear. Here, we provide genetic and pharmacologic evidence that hyperactive TGF-β1 signaling pivotally underpins osseous defects in Nf1flox/−;Col2.3Cre mice, a model which closely recapitulates the skeletal abnormalities found in the human disease. Compared to controls, we show that serum TGF-β1 levels are fivefold to sixfold increased both in Nf1flox/−;Col2.3Cre mice and in a cohort of NF1 patients. Nf1-deficient osteoblasts, the principal source of TGF-β1 in bone, overexpress TGF-β1 in a gene dosage–dependent fashion. Moreover, Nf1-deficient osteoblasts and osteoclasts are hyperresponsive to TGF-β1 stimulation, potentiating osteoclast bone resorptive activity while inhibiting osteoblast differentiation. These cellular phenotypes are further accompanied by p21-Ras–dependent hyperactivation of the canonical TGF-β1–Smad pathway. Reexpression of the human, full-length neurofibromin guanosine triphosphatase (GTPase)-activating protein (GAP)-related domain (NF1 GRD) in primary Nf1-deficient osteoblast progenitors, attenuated TGF-β1 expression levels and reduced Smad phosphorylation in response to TGF-β1 stimulation. As an in vivo proof of principle, we demonstrate that administration of the TGF-β receptor 1 (TβRI) kinase inhibitor, SD-208, can rescue bone mass deficits and prevent tibial fracture nonunion in Nf1flox/−;Col2.3Cre mice. In sum, these data demonstrate a pivotal role for hyperactive TGF-β1 signaling in the pathogenesis of NF1-associated osteoporosis and pseudarthrosis, thus implicating the TGF-β signaling pathway as a potential therapeutic target in the treatment of NF1 osseous defects that are refractory to current therapies. © 2013 American Society for Bone and Mineral Research.
Pin1‐mediated Runx2 modification is critical for skeletal development
Authors: Yoon Won‐Joon , Islam Rabia , Cho Young‐Dan , Woo Kyung‐Mi , Baek Jeong‐Hwa , Uchida Takafumi , Komori Toshihisa , van Wijnen Andre , Stein Janet L. , Lian Jane B. , Stein Gary S. , Choi Je‐Yong , Bae Suk‐Chul , Ryoo Hyun‐Mo 
Published: May 2013

AbstractRunx2 is the master transcription factor for bone formation. Haploinsufficiency of RUNX2 is the genetic cause of cleidocranial dysplasia (CCD) that is characterized by hypoplastic clavicles and open fontanels. In this study, we found that Pin1, peptidyl prolyl cis–trans isomerase, is a critical regulator of Runx2 in vivo and in vitro. Pin1 mutant mice developed CCD‐like phenotypes with hypoplastic clavicles and open fontanels as found in the Runx2+/− mice. In addition Runx2 protein level was significantly reduced in Pin1 mutant mice. Moreover Pin1 directly interacts with the Runx2 protein in a phosphorylation‐dependent manner and subsequently stabilizes Runx2 protein. In the absence of Pin1, Runx2 is rapidly degraded by the ubiquitin‐dependent protein degradation pathway. However, Pin1 overexpression strongly attenuated uniquitin‐dependent Runx2 degradation. Collectively conformational change of Runx2 by Pin1 is essential for its protein stability and possibly enhances the level of active Runx2 in vivo. J. Cell. Physiol. 228: 2377–2385, 2013. © 2013 Wiley Periodicals, Inc.
Noninvasive prenatal testing of fetal aneuploidies by massively parallel sequencing in a prospective Chinese population
Authors: Song Yijun , Liu Congcong , Qi Hong , Zhang Yunping , Bian Xuming , Liu Juntao 
Published: May 2013

ABSTRACTObjectiveThe recently developed noninvasive prenatal test (NIPT) presents a new era of prenatal screening. Previously reported studies were primarily conducted on high‐risk and advanced maternal age (AMA) pregnancies. We sought to evaluate the performance of NIPT for detection of fetal aneuploidies in a Chinese cohort of women younger than 35 years old in a prospective clinical setting.MethodsMaternal plasma samples were sequenced to identify the aneuploidies. The results were compared against the serum screening results and validated by karyotyping through invasive procedures and birth follow‐up.ResultsA total of 1916 prospectively collected maternal plasma samples were sequenced, among which 73 samples (3.8%) failed the sequencing quality control. Birth follow‐up missed 111 samples (5.8%). The remaining 1741 samples were analyzed. Sequencing reported 15 aneuploidy samples, including all the T21, T18, and T13 cases. Sequencing performed moderately in identifying sex chromosome aneuploidies, detecting two out of four samples, with a specificity of 99.88% (95% CI 99.53% to 99.98%).ConclusionsNoninvasive prenatal detection of common fetal aneuploidies is a more sensitive and specific method than triple maternal serum screening. It has a remarkable low false positive rate and is applicable to women younger than 35 years old. © 2013 John Wiley & Sons, Ltd.
New horizons for prostate cancer: part 1
Authors: Dearnaley David , Ottensmeier Christian , Attard Gerhardt , Crabb Simon 
Published: May 2013

AbstractThis report is based on a seminar held during the 9th Annual Meeting of the British Uro‐oncology Group in Bristol last September. The workshop reviewed emerging prostate cancer treatment strategies that are predicted to contribute to the changing landscape of prostate cancer management over the coming years. Immunotherapy and developments in radiotherapy are discussed in part 1 of this article, while part 2 will cover androgen receptor inhibition and novel target identification. Copyright © 2013 John Wiley & Sons
Best management practices for forest bioenergy programs
Authors: Neary Daniel G. 
Published: May 2013

Forest ecosystems produce the best quality and most consistent supplies of water for human use. The increase in the use of woody biomass as a feedstock for bioenergy production has raised questions about potential impacts on water quality. Best management practices (BMPs) have been developed and implemented since the early 1970s to ensure that forest harvesting can be conducted with minimum impact on water quality. AlthoughBMPs were originally designed to minimize water quality impacts, they can be used for a variety of environmental concerns. The use ofBMPs is widespread in developed countries and it varies from mandatory to voluntary. In many countriesBMPs are incorporated in ‘Codes of Forest Practice’ that guide forest managers through the complete bioenergy life cycle. The development and application of BMPs is not a static process, but one that relies on a continual cycle of application, assessment and monitoring, and refinement. Although some countries have “national standards,“ the complex matrix of forest ecosystems, climates, soils and topography, and harvesting systems requires ongoing assessment, monitoring, and refinement to craftBMPs to best suit local conditions. Research and development studies play a key part in the refinement and communication of improvedBMPs. They are also crucial in validating the effectiveness ofBMPs. This is especially important where local environmental conditions or operational standards are unique.BMPs ensure that forest bioenergy programs can be a sustainable part of forest management and renewable energy production.This article is categorized under:Bioenergy > Science and MaterialsBioenergy > Climate and Environment
Editorial: political abuse of psychiatry in authoritarian systems
Authors: Tobin J. P. 
Published: May 2013

We are painfully aware: Psychiatry in some states of the international community is often used to subvert the political and legal guarantees of the freedom of the individual and to violate seriously his human and legal rights (Daes,1986).ObjectiveIt can be politically convenient to incarcerate political opponents in a psychiatric hospital. It saves any potential political embarrassment that a judicial trial may present. It also undermines the credibility of opponents by labelling them with the stigma of being mentally insane. For this to occur, there has to be the acquiescence of mental health professionals and a subservient legal system.MethodThis article examines the abuse of psychiatry in two authoritarian systems, Russia and China.ResultNew diagnostic categories such as sluggish schizophrenia were created to facilitate the silencing of dissenters and were a source of self-deception for psychiatrist to placate their consciences as they operated as a tool of oppression on behalf of a political system.ConclusionIf we do not know the past, we will be condemned to repeat it.
Meta-analysis of the HTR2A–1354C/T polymorphism in schizophrenia and bipolar disorder
Authors: Gu Lian , Tan Jinjing , Su Li , Qin Yuwang , Long Jianxiong , Chen Qing , Xie Juanjuan , liang Baoyun , Yan Yan , Wu Guangliang 
Published: May 2013

ObjectiveSchizophrenia (SCZ) and bipolar disorder (BD) are common psychotic disorders, which show some overlaps in genetic aetiology. Researchers have conducted a number of studies to investigate the relationship between SCZ and the 1354C/T genetic polymorphism of 5-hydroxytryptamine receptor 2A (HTR2A–1354C/T), as well as the associations between BD and the HTR2A–1354C/T polymorphism. However, the results were conflicting. To provide a more robust estimate about the effects of the HTR2A–1354C/T polymorphism on the risk of these two psychotic disorders, we performed this meta-analysis.MethodsWe used the pooled odds ratios (ORs) with 95% confidence intervals (95% CIs) to investigate the relationships between SCZ and the 1354C/T polymorphism of HTR2A, as well as the associations between BD and HTR2A–1354C/T. Publication bias was tested by Begg's test and inverted funnel plot, and heterogeneity was checked by Cochran's Q statistic and the inconsistency index (I2).ResultsEight studies were concerned with SCZ, analysing a cumulative total of 2953 cases and 3153 controls; six papers studied BD, using a total of 923 cases and 928 controls. There was no significant association found between HTR2A–1354C/T and SCZ in the overall population (T allele vs. C allele, OR = 1.035, 95% CI 0.912–1.175, p = 0.596) or in the subgroups Caucasian population and Asian population. Moreover, there was no significant association between the HTR2A–1354C/T polymorphism and BD in the overall population (T allele vs. C allele, OR = 1.038, 95% CI = 0.607–1.772, p = 0.892).ConclusionOn the basis of these results, the HTR2A–1354C/T polymorphism is unlikely to be a risk factor for SCZ and BD.
The Structure of Galaxies: II. Fitting Functions and Scaling Relations for Ellipticals
Authors: Schombert J. M. 
Published: May 2013

AbstractSurface photometry of 311 ellipticals from the 2MASS imaging database is analyzed with respect to the two most common fitting functions: the r1/4 law and the Sérsic r1/n model. The advantages and disadvantages of each fitting function are examined. In particular, the r1/4 law performs well in the middle regions, but is inadequate for the core (inner 5 kpc) and the outer regions (beyond the half-light radius) which do not have r1/4 shapes. It is found that the Sérsic r1/n model produces good fits to the core regions of ellipticals (r<rhalf), but is an inadequate function for the entire profile of an elliptical from core to halo due to competing effects on the Sérsic n index and the fact that the interior shape of an elliptical is only weakly correlated with its halo shape. In addition, there are a wide range of Sérsic parameters that will equally describe the shape of the outer profile, degrading the Sérsic model's usefulness as a describer of the entire profile. Empirically determined parameters, such as half-light radius and total luminosity, have less scatter than fitting function variables. The scaling relations for ellipticals are often non-linear, but for ellipticals brighter than MJ < −23 the following structural relations are found: L ∝ r0.8±0.1, L ∝ Σ−0.5±0.1, and Σ ∝ r−1.5±0.1.