bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-related quality of life after successful surgery for primary hyperparathyroidism: no additive effect from vitamin D supplementation: results of a double-blind randomized study
Authors: Åberg Viveca , Norenstedt Sophie , Zedenius Jan , Sääf Maria , Nordenström Jörgen , Pernow Ylva , Nilsson Inga-Lena 
Published: November 2014

ObjectiveVitamin D insufficiency is common in primary hyperparathyroidism (pHPT). Patients with pHPT frequently have a reduced health-related quality of life (HRQoL). Our objectives were to evaluate whether HRQoL in pHPT is associated with vitamin D insufficiency and whether vitamin D supplementation after parathyroidectomy (PTX) could improve HRQoL.DesignA randomized, double-blind study (ClinicalTrials.gov identifier: NCT00982722).MethodsThe study included 150 pHPT patients randomized, 6 weeks after PTX, to daily treatment with either cholecalciferol 1600 IU and calcium carbonate 1000 mg (D+) or calcium carbonate alone (D−). HRQoL was estimated with SF-36 before and after PTX and after 12 months of study medication.ResultsThree-quarters (77%) of the pHPT patients had vitamin D insufficiency, defined as 25OHD <50 nmol/l. The pHPT patients scored lower than a reference population in all domains of SF-36. A total of 135 patients completed the entire study period. Improvements in nearly all domains were registered at the follow-up 6 weeks after PTX. At the end of the study medication period, the D+ group had a significantly higher median serum (s-) 25OHD concentration (76 (65; 93) (lower; upper interquartile ranges) vs 48 (40; 62) nmol/l, P<0.001) and a lower plasma (p-) parathyroid hormone concentration (40 (34; 52) vs 49 (38; 66) ng/l, P=0.01) than the D− group. The improvements in HRQoL remained unchanged at the follow-up 1 year after PTX. Postoperative vitamin D supplementation had no obvious effect on HRQoL.ConclusionPTX resulted in significant improvements in HRQoL. Despite a high prevalence of vitamin D insufficiency, 1 year of postoperative vitamin D supplementation had no obvious beneficial effect on HRQoL.
The Effect Occupational Exposure to Ionizing Radiation on the DNA Damage in Peripheral Blood Leukocytes of Nuclear Medicine Personnel
Authors: Dobrzyn´ska Małgorzata M. , Pachocki Krzysztof A. , Gajowik Aneta , Radzikowska Joanna , Sackiewicz Agata 
Published: November 2014

The Effect Occupational Exposure to Ionizing Radiation on the DNA Damage in Peripheral Blood Leukocytes of Nuclear Medicine Personnel: Małgorzata M. DOBRZYŃSKA, et al. Department of Radiation Hygiene and Radiobiology, National Institute of Public Health – National Institute of Hygiene, Poland—ObjectivesThe aim of this study was estimation of DNA strand breaks in leukocytes of peripheral blood of staff in a nuclear medicine department.MethodsThe exposed group consisted of 46 volunteers and the control group consisted of 40 volunteers. Samples consisting of 1 ml whole blood were collected by venepuncture. DNA damage in leukocytes was detected by alkaline comet assay.ResultsThere was no correlation between the effective dose measured by individual dosimeters and DNA damage and no differences between sexes. The mean level of damage to DNA in people exposed to ionizing radiation was significantly elevated compared with control individuals. The highest value for mean comet tail moment was noted in leukocytes of PET/CT and scintigraphy technicians (1.28 vs. 0.30 for control, p=0.013). The levels of DNA damage in leukocytes of workers in category B (effective dose may exceed 1 mSv/year) were significantly enhanced. The DNA migration of leukocytes in exposed smokers and nonsmokers was similar. In the control group the damage to DNA of leukocytes in smokers was markedly but not significantly higher compared with nonsmokers.ConclusionsOccupational exposure to ionizing radiation leads to enhanced levels of reversible DNA damage in leukocytes of nuclear medicine employees. The level of DNA damage depends on the kind of work. Cigarette smoking is related to the increase in DNA damage in unexposed individuals but not in nuclear medicine workers. Radiation seems to be a stronger inducer of DNA damage than smoking. Although most of the DNA damage detected by comet assay is repaired, further improvement of radiation safety should be taken under consideration.
Estágio como fonte de conhecimento ou mão-de-obra menos onerosa?
Authors: Pfischer Elisete Dahmer , Lorardi Joisse Antônio , Marian Sérgio , Nascimento Letícia Fátima , Pfischer Paulo César , Nascimento Michely 
Published: November 2014

A interação entre a gestão de conhecimento e os estágios leva a uma avaliação dos procedimentos adotados pelas empresas concedentes. Os estagiários, por sua vez, esperam obter benefícios de ensino e aprendizagem, como também econômicos. Estes últimos na maioria das vezes ocorrem para subsidiar as despesas advindas da sua permanência na universidade. Contudo, quando iniciam a tão almejada etapa deestágio, normalmente a partir da 5ª fase, se deparam com uma realidade não esperada. Alguns são utilizados como ubstitutos de outros funcionários, servindo assim como "mão-de-obra barata," pela não incidência dos encargos sociais. Notificase, entretanto, que a aplicação dos conhecimentos obtidos na academia pode proporcionar oportunidades profissionais aos acadêmicos, se existir uma melhor forma de monitoramento, integrando instituições de ensino e empresas.
Antimicrobial Photodynamic Therapy as an Adjunct to Non‐Surgical Treatment of Aggressive Periodontitis: A Split‐Mouth Randomized Controlled Trial
Authors: Moreira André L. , Novaes Arthur B. , Grisi Márcio F. , Taba Mario , Souza Sérgio L. , Palioto Daniela B. , de Oliveira Paula G. , Casati Marcio Z. , Casarin Renato C. , Messora Michel R. 
Published: November 2014

Background: The management of aggressive periodontitis (AgP) represents a challenge for clinicians because there are no standardized protocols for an efficient control of the disease. This randomized controlled clinical trial evaluated the effects of repeated applications of antimicrobial photodynamic therapy (aPDT) adjunctive to scaling and root planing (SRP) in patients with AgP.Methods: Using a split‐mouth design, 20 patients with generalized AgP were treated with aPDT + SRP (test group) or SRP only (control group). aPDT was applied at four periods. All patients were monitored for 90 days. Clinical, microbiologic, and immunologic parameters were statistically analyzed.Results: In deep periodontal pocket analysis (probing depth [PD] ≥7 mm at baseline), the test group presented a decrease in PD and a clinical attachment gain significantly higher than the control group at 90 days (P <0.05). The test group also demonstrated significantly less periodontal pathogens of red and orange complexes and a lower interleukin‐1β/interleukin‐10 ratio than the control group (P <0.05).Conclusion: The application of four sessions of aPDT, adjunctive to SRP, promotes additional clinical, microbiologic, and immunologic benefits in the treatment of deep periodontal pockets in single‐rooted teeth in patients with AgP.
Prevalence and Predictive Factors for Peri‐Implant Disease and Implant Failure: A Cross‐Sectional Analysis
Authors: Daubert Diane M. , Weinstein Bradley F. , Bordin Sandra , Leroux Brian G. , Flemmig Thomas F. 
Published: November 2014

Background: Long‐term studies worldwide indicate that peri‐implant inflammation is a frequent finding and that the prevalence of peri‐implantitis correlates with loading time. Implant loss, although less frequent, has serious oral health and economic consequences. An understanding of predictive factors for peri‐implant disease and implant loss would help providers and patients make informed decisions.Methods: A cross‐sectional study was performed on 96 patients with 225 implants that were placed between 1998 and 2003. Implant placement data were collected from patient records, and patients presented for a clinical and radiographic follow‐up examination. Implant status and periodontal status were determined, the data were analyzed to determine the prevalence of peri‐implant disease or implant loss, and a predictive model was tested.Results: The mean follow‐up time for the patients was 10.9 years. The implant survival rate was 91.6%. Peri‐implant mucositis was found in 33% of the implants and 48% of the patients, and peri‐implantitis occurred in 16% of the implants and 26% of the patients. Individuals with peri‐implantitis were twice as likely to report a problem with an implant as individuals with healthy implants. Peri‐implantitis is associated with younger ages and diabetes at the time of placement and with periodontal status at the time of follow‐up. Implant loss is associated with diabetes, immediate placement, and larger‐diameter implants.Conclusions: One in four patients and one in six implants have peri‐implantitis after 11 years. The data suggest that periodontal and diabetes status of the patient may be useful for predicting implant outcomes.
Advanced Glycation End Products Upregulate the Endoplasmic Reticulum Stress in Human Periodontal Ligament Cells
Authors: Xu Jie , Xiong Ming , Huang Bin , Chen Huangqin 
Published: November 2014

Background: The accumulation of advanced glycation end products (AGEs) appears to be the main factor responsible for modulating periodontal inflammation in diabetes. The aim of this study is to examine the effects of AGEs on inflammation in human periodontal ligament cells and to investigate the mechanism with a specific emphasis on the role of endoplasmic reticulum (ER) stress–induced nuclear factor‐kappa B (NF‐κB) pathway.Methods: Cytotoxicity was measured by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay. The protein expressions of ER markers and NF‐κB were examined by Western blot analysis. The translocation of NF‐κB was observed by immunofluorescence assay. Proinflammatory chemokine production was determined by enzyme‐linked immunosorbent assay.Results: Treatment with AGEs reduced cell viability in a concentration‐ and time‐dependent manner. AGEs induced ER stress, as evidenced by survival molecules, such as glucose‐regulated protein 78 (GRP78), double‐stranded RNA‐activated protein kinase–like ER kinase (PERK), and activating transcription factor 6 (ATF‐6), and apoptotic molecules, such as CCAAT/enhancer binding protein homologous protein (CHOP) and caspase 12. AGEs upregulated the nucleoprotein expression of NF‐κB, enhanced translocation of NF‐κB from the cytoplasm to the nucleus, and increased the production of proinflammatory chemokines interleukin‐6 and interleukin‐8.Conclusion: AGEs mediate inflammation of human periodontal ligament cells via the ER stress–induced NF‐κB pathway.
Histologic Healing Following Tooth Extraction With Ridge Preservation Using Mineralized Versus Combined Mineralized‐Demineralized Freeze‐Dried Bone Allograft: A Randomized Controlled Clinical Trial
Authors: Borg Tyler D. , Mealey Brian L. 
Published: November 2014

Background: Mineralized and demineralized freeze‐dried bone allografts (FDBAs) are used in alveolar ridge (AR) preservation; however, each material has advantages and disadvantages. Combinations of allografts aimed at capitalizing on the advantages each offers are available. To date, there is no evidence to indicate if a combination allograft is superior in this application. The primary objective of this study is to histologically evaluate and compare healing of non‐molar extraction sites grafted with either mineralized FDBA or a 70:30 mineralized:demineralized FDBA combination allograft in AR preservation. The secondary objective is to compare dimensional changes in ridge height and width after grafting with these two materials.Methods: Forty‐two patients randomized into two equal groups received ridge preservation with either 100% mineralized FDBA (active control group) or the combination 70% mineralized: 30% demineralized allograft (test group). Sites were allowed to heal for 18 to 20 weeks, at which time core biopsies were obtained and dental implants were placed. AR dimensions were evaluated at the time of extraction and at implant placement, including change in ridge width and change in buccal and lingual ridge height. Histomorphometric analysis was performed to determine percentage of vital bone, residual graft, and connective tissue/other non‐bone components.Results: There was no significant difference between groups in AR dimensional changes. Combination allograft produced increased vital bone percentage (36.16%) compared to the FDBA group (24.69%; P = 0.0116). The combination allograft also had a significantly lower mean percentage of residual graft particles (18.24%) compared to FDBA (27.04%; P = 0.0350).Conclusions: This study provides the first histologic evidence showing greater new bone formation with a combination mineralized/demineralized allograft compared to 100% mineralized FDBA in AR preservation in humans. Combination allograft results in increased vital bone formation while providing similar dimensional stability of the AR compared to FDBA alone in AR preservation.
Neuronal T-Cell Autoreactivity Is Amplified in Overweight Children With New-Onset Insulin-Requiring Diabetes
Authors: Buryk Melissa A. , Dosch H-Michael , Libman Ingrid , Arena Vincent C. , Huang Yihe , Cheung Roy K. , Trucco Massimo , Pietropaolo Massimo , Becker Dorothy J. 
Published: November 2014

OBJECTIVEDisease-associated T-cell autoreactivities are seen in most type 1 diabetic patients and are thought to emerge before islet autoantibodies, but host factors that impact autoimmune elements remain uncertain. We assessed if adiposity and measures of insulin sensitivity impact T- and B-cell autoimmunity in children with insulin-requiring diabetes.RESEARCH DESIGN AND METHODSInsulin-requiring children and adolescents diagnosed between January 2004 and June 2008 were studied (n = 261): age 9.7 ± 4 years, 92% white, and 60% male. T-cell responses to 10 diabetes-associated antigens, β-cell autoantibodies (GADA, IA-2A, IAA, and ICA), BMI z score (BMIz), and waist percentile were measured at onset and 3 months later.RESULTSAll but one subject had either T- or B-cell autoimmunity. Diabetes-associated T-cell autoreactivities were found in 92% of subjects. Higher amplitude T-cell autoreactivities to neuronal diabetes-associated autoantigens were seen in those with the highest BMIz quintile, BMI ≥85th percentile (P &lt; 0.05), and waist circumference ≥85th percentile (P &lt; 0.05). There were no relationships between the number of T-cell reactivities or T-cell diversity with adiposity measures or autoantibody number or type. Patients with positive T-cell reactivities but without autoantibodies had the highest BMIz (P = 0.006).CONCLUSIONSOur observations link obesity and diabetes-related autoimmunity, suggesting an amplification of neuronal T-cell autoimmunity associated with adiposity and/or insulin resistance, with obesity-related inflammation possibly enhancing islet autoimmunity.
Racial and ethnic disparities in discharge to rehabilitation following traumatic brain injury
Authors: Meagher Ashley D. , Beadles Christopher A. , Doorey Jennifer , Charles Anthony G. 
Published: November 2014

OBJECT
Disparities in access to inpatient rehabilitation services after traumatic brain injury (TBI) have been identified, but less well described is the likelihood of discharge to a higher level of rehabilitation for Hispanic or black patients compared with non-Hispanic white patients. The authors investigate racial disparities in discharge destination (inpatient rehabilitation vs skilled nursing facility vs home health vs home) following TBI by using a nationwide database and methods to address racial differences in prehospital characteristics.

METHODS
Analysis of discharge destination for adults with moderate to severe TBI was performed using National Trauma Data Bank data for the years 2007–2010. The authors performed propensity score weighting followed by ordered logistic regression in their analytical sample and in a subgroup analysis of older adults with Medicare. Likelihood of discharge to a higher level of rehabilitation based on race/ethnicity accounting for prehospital and in-hospital variables was determined.

RESULTS
The authors identified 299,205 TBI incidents: 232,392 non-Hispanic white, 29,611 Hispanic, and 37,202 black. Propensity weighting resulted in covariate balance among racial groups. Hispanic (adjusted OR 0.71, 95% CI 0.68–0.75) and black (adjusted OR 0.94, 95% CI 0.91–0.97) populations were less likely to be discharged to a higher level of rehabilitation than were non-Hispanic whites. The subgroup analysis indicated that Hispanic (adjusted OR 0.79, 95% CI 0.71–0.86) and black (OR 0.87, 95% CI 0.81–0.94) populations were still less likely to receive a higher level of rehabilitation, despite uniform insurance coverage (Medicare).

CONCLUSIONS
Adult Hispanic and black patients with TBI are significantly less likely to receive intensive rehabilitation than their non-Hispanic white counterparts; notably, this difference persists in the Medicare population (age ≥ 65 years), indicating that uniform insurance coverage alone does not account for the disparity. Given that insurance coverage and a wide range of prehospital characteristics do not eliminate racial disparities in discharge destination, it is crucial that additional unmeasured patient, physician, and institutional factors be explored to eliminate them.
Management of C1–2 traumatic fractures using an intraoperative 3D imaging–based navigation system
Authors: Costa Francesco , Ortolina Alessandro , Attuati Luca , Cardia Andrea , Tomei Massimo , Riva Marco , Balzarini Luca , Fornari Maurizio 
Published: November 2014

OBJECT
Fractures of C-1 and C-2 are complex and surgical management may be difficult and challenging due to the anatomical relationship sbetween the vertebrae and neurovascular structures. The aim of this study was to evaluate the role, reliability, and accuracy of cervical fixation using the O-arm intraoperative 3D image–based navigation system.

METHODS
The authors evaluated patients who underwent a navigation system–based surgery for stabilization of a fracture of C-1 and/or C-2 from August 2011 to August 2013. All of the fixation screws were intraoperatively checked and their position was graded.

RESULTS
The patient population comprised 17 patients whose median age was 47.6 years. The surgical procedures were as follows: anterior dens screw fixation in 2 cases, transarticular fixation of C-1 and C-2 in 1 case, fixation using the Harms technique in 12 cases, and occipitocervical fixation in 2 cases. A total of 67 screws were placed. The control intraoperative CT scan revealed 62 screws (92.6%) correctly placed, 4 (5.9%) with a minor cortical violation (< 2 mm), and only 1 screw (1.5%) that was judged to be incorrectly placed and that was immediately corrected. No vascular injury of the vertebral artery was observed either during exposition or during screw placement. No implant failure was observed.

CONCLUSIONS
The use of a navigation system based on an intraoperative CT allows a real-time visualization of the vertebrae, reducing the risks of screw misplacement and consequent complications.
Parents tardifs, enfant précoce ? Assistance médicale à la procréation et haut potentiel intellectuel
Authors: Weismann-Arcache Catherine 
Published: November 2014

Nos recherches sur les enfants et adolescents dits surdoués ont révélé la fréquence des procréations médicalement assistées. Ces modalités particulières de la réalisation du désir d’enfant sont-elles traumatiques, appellent-elles un surinvestissement de l’enfant, et peut-on considérer le haut potentiel des enfants comme un réponse anti-traumatique ? Les rares études longitudinales sur les enfants nés par assistance médicale à la procréation font état de la fréquence de l’avance scolaire, attribuée à un suivi attentif de la part des parents. Sans vouloir généraliser la corrélation haut potentiel/assistance médicale à la procréation, ces données méritent néanmoins d’être interrogées à la lumière de nos travaux : 1/ Chez les enfants dits surdoués, la survivance des théories sexuelles infantiles vient alimenter des centres d’intérêt particuliers concernant l’origine et la fin. Les théories sexuelles infantiles serviront de fil d’Ariane car elles sont fortement réactivées chez les couples faisant appel à ces techniques ; 2/ Les thèmes du géniteur, de la genèse et du génie se recoupent au plan étymologique : géniteur est issu du latin genitorem, genitum (engendrer) et génie vient du latin Genius (dieu qui donnait la vie à toutes choses). Les travaux sur les origines du génie scientifique littéraire ou artistique mettent régulièrement en évidence des origines obscures et la recherche d’un savoir surdéveloppé associé à une sensibilité aigüe dans un domaine très investi. Des vignettes cliniques viendront illustrer le propos et tenter de déterminer s’il s’agit d’un processus pathologique ou structurant.
Biographie d’une photo numérique et pouvoir des tags
Authors: Boullier Dominique , Crépel Maxime 
Published: November 2014

La photo a changé de statut depuis qu’elle est numérique, en grande partie parce qu’elle peut désormais être stockée, publiée, taguée, échangée dans des bases de données en ligne, telles que Flickr. Sa biographie repose alors sur les métadonnées qu’elle emporte avec elle. C’est elle qui rend possibles les connexions entre mondes sociaux si divers sur les réseaux. Cependant, le rôle de la base de données mérite aussi d’être pris en compte ; base mémoire mais aussi base action et ses algorithmes spécifiques lui font jouer un rôle à chaque fois différent. Pourtant, photo comme base de données dépendent d’éléments plus simples que sont les attributs, chaque métadonnée pouvant produire la circulation qui sera décisive pour la vie de la photo comme pour la base de données. Ces attributs agissent alors comme monades dont le pouvoir d’extension est amplifié par le numérique de façon remarquable.
Savoirs fragmentés
Authors: Jungen Christine 
Published: November 2014

Comment cataloguer un manuscrit arabe sous forme de microfilm ? À partir d’une enquête menée dans deux centres de collecte de microfilms de manuscrits, cet article examine le geste de cataloguer, la constitution d’une notice comme mode de construction de portraits irréductibles les uns aux autres. À l’ère de la standardisation et de l’interopérabilité des catalogues, il s’agit ici de comprendre comment les catalogages in situ d’un objet à la matérialité propre proposent, à rebours des rêves de maîtrise complète, de collection totale et universelle de l’ensemble des manuscrits existants, des formulations et des configurations chaque fois singulières entre le texte, la collection et le corpus de ce qui est défini comme le « patrimoine manuscrit arabe et islamique ».
Diagnostic néonatal et recompositions temporelles
Authors: Minguet Guy , Langeard Chloe 
Published: November 2014

Cet article a pour objectif de reconstituer la structuration temporelle qui cadre le protocole diagnostique et l’annonce d’une maladie rare, la mucoviscidose. Le travail de structuration temporelle sous-tend à la fois l’algorithme diagnostique et la prise en charge des malades. L’analyse sociologique prend acte à la fois d’une dynamique de rationalisation des dispositifs, des pratiques de prise en charge et d’une préservation des capacités d’autorégulation professionnelle au nom du caractère improbable de la pathologie, de la singularité des cas et de l’incertitude. Les professionnels, selon leur positionnement dans la chaîne de prise en charge, interprètent, allouent leur temps et tirent avantage de leur expertise, comme de la flexibilité temporelle octroyée par le processus de consultation pour la file active des patients et la capacité d’absorption des nouveaux cas suspects. Nos résultats mettent en exergue quatre formes de scansion des temporalités : l’accélération du temps face à l’enjeu de la précocité du diagnostic, la domestication du temps au défi de la contraction tendancielle entre dépistage et diagnostic, la suspension du temps au-devant des formes cliniques frontières et rares, la remontée du temps face au scénario de diagnostic anténatal et préimplantatoire.