bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lived experiences of village-based patients with chronic kidney disease receiving haemodialysis at Mirpur, Azad Kashmir, Pakistan: a transcendental phenomenology study protocol
Authors: Akhtar Tazeem , Pienaar Abel J , Asmat Kainat , Khalil Fareeha 
Published: July 2024

BackgroundChronic kidney disease (CKD) is one of the major health issues in Pakistan, exerting notable effects on both the physical and mental well-being of individuals undergoing haemodialysis. Of particular concern to healthcare professionals is the potential adverse influence of haemodialysis on the lives of patients with CKD residing in rural areas of the country. This study will explore and describe the lived experiences and needs of patients with CKD receiving haemodialysis from the perspectives of patients and their family caregivers.Methods and analysisTranscendental phenomenological research design will be used. Participants will be recruited from the dialysis centre of a tertiary hospital through purposive sampling based on specific inclusion criteria. In-depth unstructured interviews, observation and document analysis will be the methods for data collection. Data will be analysed using Colaizzi’s approach following the transcription of the interviews.Ethics and disseminationThe study has been approved by the Institutional Review Board (IRB) of Shifa Tameer-e-Millat University, Pakistan (IRB # 0307–23) and written permission was obtained from the administration of the study hospital. Before giving written and verbal consent, all participants will receive detailed information about the study. Participants will maintain the freedom to withdraw from the study at any point. Confidentiality of the participants will be ensured. The study findings will be disseminated to important stakeholders and published in scientific papers and conference proceedings.
Hypergeometric Gevrey-0 approximation for the Gevrey-k divergent series with application to eight-loop renormalization group functions of the O(N)-symmetric field model
Authors: Shalaby Abouzeid M. , Abdelhamid Hamdi M. , Elkamash I. S. 
Published: July 2024

AbstractMera et al. (Phys Rev Lett 115:143001, 2015) discovered that the hypergeometric function $${}_2F_1(a_1,a_2;b_1; \omega g)$$

2

F
1

(

a
1

,

a
2

;

b
1

;
ω
g
)

can serve as an accurate approximant for a divergent Gevrey-1 type of series with an asymptotic large-order behavior of the form $$n! n^b \sigma ^n$$

n
!

n
b

σ
n

. What is strange about this approximant is that it has a series expansion with the wrong large-order behavior (Gevrey-0 type). In this work, we extend this discovery to Gevrey-k series where we show that the hypergeometric approximants and its extension to the generalized hypergeometric approximants are not only able to approximate divergent (Gevrey-1) series but also able to approximate strongly-divergent series of Gevrey-k type with $$k=2,3,\ldots$$

k
=
2
,
3
,
…

. Moreover, we show that these hypergeometric approximants are able to predict accurate results for the non-perturbative strong-coupling and large-order parameters from weak-coupling data as input. Examples studied here are the ground-state energy for the $$x^n$$

x
n

anharmonic oscillators. The hypergeometric approximants are also used to approximate the recent eight-loop series ( g-expansion) of the renormalization group functions for the O(N)-symmetric $$\phi ^4$$

ϕ
4

scalar field model. Form these functions for $$N=0, 1, 2$$

N
=
0
,
1
,
2

, and 3, critical exponents are extracted which are very competitive to results from more sophisticated approximation techniques.
Mechanisms of Response and Tolerance to Active RAS Inhibition in KRAS-Mutant Non–Small Cell Lung Cancer
Authors: Araujo Haniel A. , Pechuan-Jorge Ximo , Zhou Teng , Do Minh Truong , Hu Xin , Rojas Alvarez Frank R. , Salvatierra Maria E. , Ibarguen Heladio P. , Lee Richard , Raghulan Rashi , Shah Harshit , Moreno Ayala Mariela A. , Chen Kevin , Tovbis Shifrin Nataliya , Wu Shuhong , Solis Soto Luisa M. , Negrao Marcelo V. , Gibbons Don L. , Hong David S. , Roth Jack A. , Heymach John V. , Zhang Jianjun , Jiang Jingjing , Singh Mallika , Smith Jacqueline A.M. , Quintana Elsa , Skoulidis Ferdinandos 
Published: July 2024

Abstract
Resistance to inactive state-selective RASG12C inhibitors frequently entails accumulation of RASGTP, rendering effective inhibition of active RAS potentially desirable. Here, we evaluated the antitumor activity of the RAS(ON) multiselective tricomplex inhibitor RMC-7977 and dissected mechanisms of response and tolerance in KRASG12C-mutant non–small cell lung cancer (NSCLC). Broad-spectrum reversible RASGTP inhibition with or without concurrent covalent targeting of active RASG12C yielded superior and differentiated antitumor activity across diverse comutational KRASG12C-mutant NSCLC mouse models of primary or acquired RASG12C(ON) or RASG12C(OFF) inhibitor resistance. Interrogation of time-resolved single-cell transcriptional responses established an in vivo atlas of multimodal acute and chronic RAS pathway inhibition in the NSCLC ecosystem and uncovered a regenerative mucinous transcriptional program that supports long-term tumor cell persistence. In patients with advanced KRASG12C-mutant NSCLC, the presence of mucinous histologic features portended poor response to sotorasib or adagrasib. Our results have potential implications for personalized medicine and the development of rational RAS inhibitor-anchored therapeutic strategies.
Significance: Our work reveals robust and durable antitumor activity of the preclinical RAS(ON) multiselective inhibitor RMC-7977 against difficult-to-treat subsets of KRASG12C-mutant NSCLC with primary or acquired RASG12C inhibitor resistance and identifies a conserved mucinous transcriptional state that supports RAS inhibitor tolerance.
See related commentary by Marasco and Misale, p. 2018
Preclinical Direct Endoluminal Assessment of Endothelialization After Flow Diversion With Microangioscopy
Authors: Srinivasan Visish M. , Garcia Roberto L. , Shekhtman Oleg , Robledo Ariadna , Lazaro Tyler , Rao Abhijit , O'Leary Sean , Husain Adam , Covell Michael M. , Phillips Michael , Cooper Phillip , Duncan Richard Forrest , Bolanos Oscar , Colasurdo Marco , Edhayan Gautam , Chen Stephen R. , Fahed Robert , Kan Peter 
Published: July 2024

Background
Direct endoluminal imaging, such as with our previously described microangioscope, is an emerging adjunct in endovascular cerebral aneurysm management that enables clinicians to delineate between thrombi and visualize neoepithelialization after stent placement with high resolution. The present study sought to study flow diversion in vivo under direct endoluminal imaging, and to validate our findings with histopathology.

Methods
In a rabbit model, we implanted each left common carotid artery with a shielded flow diverter (FD) (Medtronic Pipeline Vantage) and nonshielded FD (Medtronic Pipeline Flex) in the right common carotid artery. We studied 9 animals in 3 groups: (1) no periprocedural antiplatelet therapy, (2) aspirin 81 mg daily, and (3) aspirin 81 mg and clopidogrel 75 mg daily. FD thrombosis, stenosis, malapposition, and neoepithelialization were all evaluated by diagnostic cerebral angiography and microangioscopy after 30 days. Diagnostic cerebral angiography and angioscopic video were analyzed by independent evaluators and compared with histopathologic analysis.

Results

In the aspirin and dual antiplatelet therapy groups, there were no significant observed differences in stent thrombosis, stenosis, malapposition, or neoepithelialization between the shielded and non‐shielded FD groups. There was significantly more thrombus formation in Group 1. Neointimal thickness as measured by the microangioscope was highly correlated with histology (r = 0.72;
P
= 0.016). Interrater agreement of microangioscope videos was highest for FD thrombosis and stenosis.

Conclusion
In‐stent thrombosis, stenosis, malapposition, and neopithelialization demonstrated no significant difference between shielded and non‐shielded FDs. Microangioscopy measurements for neointimal thickness were highly correlated with pathology and may be a helpful adjunct to diagnostic cerebral angiography in FD follow‐up.
Endovascular Therapy for Isolated Cervical Internal Carotid Artery Occlusion
Authors: Falkesgaard Katrine , Hedegaard Jakob N. , Jensen Jonas , Leslie‐Mazwi Thabele M. , Blauenfeldt Rolf A. , Simonsen Claus Z. 
Published: July 2024

Background
Guidelines on endovascular therapy for acute ischemic stroke do not include isolated cervical internal carotid artery (cICA) occlusions. The effect of treating these lesions remains unclear. This study aimed to compare the baseline characteristics and treatment outcomes between patients with isolated cICA occlusions to patients who underwent endovascular therapy due to a level of occlusion supported by guidelines.

Methods
A retrospective cohort study was conducted on 1162 patients who underwent endovascular therapy. Of these, 115 had an isolated cICA occlusion. Univariate analysis of baseline characteristics and outcome measured by the modified Rankin scale 90 days after endovascular therapy were compared between patients with isolated cICA occlusion, those with tandem occlusions, and those with occlusions of the middle cerebral artery/top of the internal carotid artery (first segment of the middle cerebral artery/intracranial internal carotid artery). To adjust for confounders, an inverse probability of treatment weighting was performed.

Results

Patients with isolated cICA occlusions were more likely men (67.8% versus 50.9%;
P
<0.001) and active smokers (42.2% versus 26.4%;
P
= 0.002) compared with patients with first segment of the middle cerebral artery/intracranial internal carotid artery occlusions where atrial fibrillation was more common (35.5% versus 23.5%;
P
= 0.02). Patients with an isolated cICA had a lower chance of achieving a modified Rankin scale score of 0 to 2 at 90 days (adjusted relative risk, 0.71 [95% CI, 0.54–0.92]) and a higher mortality rate (adjusted relative risk, 1.97 [95% CI, 1.36–2.87]) compared with patients with first segment of the middle cerebral artery/intracranial internal carotid artery occlusions.

Conclusion
Patients with isolated cICA occlusions and first segment of the middle cerebral artery/intracranial internal carotid artery occlusions differ in sex, smoking status, and rate of atrial fibrillation. Patients with isolated cICA occlusions have lower reperfusion rates, worse outcome, and a higher mortality rate.
Apnoea suppresses brain activity in infants
Authors: Zandvoort Coen S. , Dereymaeker Anneleen , Baxter Luke , Jansen Katrien , Naulaers Gunnar , de Vos Maarten , Hartley Caroline 
Published: July 2024

Abstract
Apnoea—the cessation of breathing—is commonly observed in premature infants. These events can reduce cerebral oxygenation and are associated with poorer neurodevelopmental outcomes. However, relatively little is known about how apnoea and shorter pauses in breathing impact brain function in infants, which will provide greater mechanistic understanding of how apnoea affects brain development. We analysed simultaneous recordings of respiration, electroencephalography (EEG), heart rate, and peripheral oxygen saturation in 124 recordings from 118 infants (post-menstrual age: 38.6 ± 2.7 weeks [mean ± standard deviation]) during apnoeas (pauses in breathing greater than 15 seconds) and shorter breathing pauses between 5 and 15 seconds. EEG amplitude significantly decreased during both apnoeas and short breathing pauses compared with normal breathing periods. Change in EEG amplitude was significantly associated with change in heart rate during apnoea and short breathing pauses and, during apnoeas only, with oxygen saturation change. No associations were found between EEG amplitude changes and apnoea/pause duration, post-menstrual age, or sleep state. As apnoeas often occur in premature infants, frequent disruption to brain activity may impact neural development and result in long-term neurodevelopmental consequences.
BOLD fMRI responses to amplitude-modulated sounds across age in adult listeners
Authors: Fuglsang Søren A. , Märcher-Rørsted Jonatan , Madsen Kristoffer H. , Frantzen Ditte H. , Encina-Llamas Gerard , Sørensen Charlotte , Dyrby Tim B. , Dau Torsten , Hjortkjær Jens , Siebner Hartwig R. 
Published: July 2024

Abstract
Age-related alterations in the auditory system have been suggested to affect the processing of temporal envelope amplitude modulations (AM) at different levels of the auditory hierarchy, yet few studies have used functional magnetic resonance imaging (fMRI) to study this noninvasively in humans with high spatial resolution. In this study, we utilized sparse-sampling fMRI at 3 Tesla (3T) to investigate regional blood oxygenation level-dependent (BOLD) responses to AM noise stimuli in 65 individuals ranging in age from 19 to 77 years. We contrasted BOLD responses to AM noise stimuli modulated at 4 Hz or 80 Hz with responses to unmodulated stimuli. This allowed us to derive functional measures of regional neural sensitivity to the imposed AM. Compared with unmodulated noise, slowly varying 4 Hz AM noise stimuli elicited significantly greater BOLD responses in the left and right auditory cortex along the Heschl’s gyrus (HG). BOLD responses to the 80 Hz AM stimuli were significantly greater than responses to unmodulated stimuli in putatively primary auditory cortical regions in the lateral HG. BOLD responses to 4 Hz AM stimuli were significantly greater in magnitude than responses to 80 Hz AM stimuli in auditory cortical regions. We find no discernible effects of age on the functional recruitment of the auditory cortex by AM stimuli. While the results affirm the involvement of the auditory cortex in processing temporal envelope rate information, they provide no support for age-related effects on these measures. We discuss potential caveats in assessing age-related changes in responses to AM stimuli in the auditory pathway.
The Wise Mind Balances the Abstract and the Concrete
Authors: Grossmann Igor , Peetz Johanna , Dorfman Anna , Rotella Amanda , Buehler Roger 
Published: July 2024

Abstract
We explored how individuals’ mental representations of complex and uncertain situations impact their ability to reason wisely. To this end, we introduce situated methods to capture abstract and concrete mental representations and the switching between them when reflecting on social challenges. Using these methods, we evaluated the alignment of abstractness and concreteness with four integral facets of wisdom: intellectual humility, open-mindedness, perspective-taking, and compromise-seeking. Data from North American and UK participants (N = 1,151) revealed that both abstract and concrete construals significantly contribute to wise reasoning, even when controlling for a host of relevant covariates and potential response bias. Natural language processing of unstructured texts among high (top 25%) and low (bottom 25%) wisdom participants corroborated these results: semantic networks of the high wisdom group reveal greater use of both abstract and concrete themes compared to the low wisdom group. Finally, employing a repeated strategy-choice method as an additional measure, our findings demonstrated that individuals who showed a greater balance and switching between these construal types exhibited higher wisdom. Our findings advance understanding of individual differences in mental representations and how construals shape reasoning across contexts in everyday life.
A new species of Ramaria subg. Laeticolora from Meghalaya, India
Authors: BISWAS PINKY RANI , DUTTA ARUN KUMAR 
Published: July 2024

A new species of coralloid fungus from Meghalaya, India, Ramaria pseudovinosimaculans, belonging to the genus Ramaria subg. Laeticolora, is proposed based on taxonomy and phylogenetic studies of the internal transcribed spacer of the ribosomal DNA (nrITS) region. The morphological characteristics, together with molecular studies, confirmed that the species is a novel species. The species is characterized by a small to medium-sized, radially branched, white to yellowish white basidiomata with a base colour of light brown to violet red and greyish yellow elsewhere that turns brownish orange when bruised, a cylindrical to bacilliform basidiospore, basally clamped four-spored basidia, and clamped hyphae. An inclusive description, illustration, and comparison with morphologically similar and related species are provided.
L-theanine alleviates myocardial ischemia/reperfusion injury by suppressing oxidative stress and apoptosis through activation of the JAK2/STAT3 pathway in mice
Authors: Li Qi , Ding Jiaqi , Xia Boyu , Liu Kun , Zheng Koulong , Wu Jingjing , Huang Chao , Yuan Xiaomei , You Qingsheng 
Published: July 2024

Abstract
Background
L-theanine is a unique non-protein amino acid in tea that is widely used as a safe food additive. We investigated the cardioprotective effects and mechanisms of L-theanine in myocardial ischemia-reperfusion injury (MIRI).

Methods
The cardioprotective effects and mechanisms of L-theanine and the role of Janus Kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling were investigated in MIRI mice using measures of cardiac function, oxidative stress, and apoptosis.

Results
Administration of L-theanine (10 mg/kg, once daily) suppressed the MIRI-induced increase in infarct size and serum creatine kinase and lactate dehydrogenase levels, as well as MIRI-induced cardiac apoptosis, as evidenced by an increase in Bcl-2 expression and a decrease in Bax/caspase-3 expression. Administration of L-theanine also decreased the levels of parameters reflecting oxidative stress, such as dihydroethidium, malondialdehyde, and nitric oxide, and increased the levels of parameters reflecting anti-oxidation, such as total antioxidant capacity (T-AOC), glutathione (GSH), and superoxide dismutase (SOD) in ischemic heart tissue. Further analysis showed that L-theanine administration suppressed the MIRI-induced decrease of phospho-JAK2 and phospho-STAT3 in ischemic heart tissue. Inhibition of JAK2 by AG490 (5 mg/kg, once daily) abolished the cardioprotective effect of L-theanine, suggesting that the JAK2/STAT3 signaling pathway may play an essential role in mediating the anti-I/R effect of L-theanine.

Conclusions
L-theanine administration suppresses cellular apoptosis and oxidative stress in part via the JAK2/STAT3 signaling pathway, thereby attenuating MIRI-induced cardiac injury. L-theanine could be developed as a potential drug to alleviate cardiac damage in MIRI.
The need of centralized coordination to counter biological invasions in the European Union
Authors: Kurtul Irmak , Haubrock Phillip J. 
Published: July 2024

AbstractNon-native species monitoring faces global challenges due to resource disparities, hindering effective implementation. Current strategies are fragmented and resource-dependent, inadequately addressing non-native species dynamics and are subjected to reporting biases, being further ridiculed by political borders. To overcome these challenges, a paradigm shift towards targeted, large-scale monitoring is crucial, requiring standardized protocols and advanced technologies like environmental DNA analysis, orchestrated, applied—and enforced—following international collaboration. Despite existing efforts, networks, and laws, even larger political entities like the European Union suffer from the lack of information exchange as well as economic, political, and socio-cultural differences among member status, ultimately hampering united efforts against the threat posed by non-native species. The absence of a comprehensive central hub and authority, guided by scientific input and at the same time empowered by being a political institution, emerges as a compelling solution. Despite potential drawbacks, this institution, possibly bridging gaps in the large-scale approach, could coordinate efforts, standardize reporting, allocate resources, and advocate increased funding. Considering rising introduction rates and accelerating impacts from non-native species, creating a centralized institution becomes imperative for enhancing global non-native species monitoring and management to foster a collaborative response to non-native species threats.
Genome-wide identification of the Q-type C2H2 zinc finger protein gene family and expression analysis under abiotic stress in lotus (Nelumbo nucifera G.)
Authors: Liu Huan , Liu Yidan , Liu Fangyu , Zeng Lihong , Xu Yingchun , Jin Qijiang , Wang Yanjie 
Published: July 2024

Abstract
Background
Lotus (Nelumbo nucifera G.) is an important aquatic plant with high ornamental, economic, cultural and ecological values, but abiotic stresses seriously affect its growth and distribution. Q-type C2H2 zinc finger proteins (ZFPs) play an important role in plant growth development and environmental stress responses. Although the Q-type C2H2 gene family has been identified in some plants, limited reports has been carried out it in lotus.

Results
In this study, we identified 45 Q-type NnZFP members in lotus. Based on the phylogenetic tree, these Q-type NnZFP gene family members were divided into 4 groups, including C1-1i, C1-2i, C1-3i and C1-4i. Promoter cis-acting elements analysis indicated that most Q-type NnZFP gene family members in lotus were associated with response to abiotic stresses. Through collinearity analyses, no tandem duplication gene pairs and 14 segmental duplication gene pairs were identified, which showed that duplication events might play a key role in the expansion of the Q-type NnZFP gene family. The synteny results suggested that 54 and 28 Q-type NnZFP genes were orthologous to Arabidopsis and rice, respectively. The expression patterns of these Q-type NnZFP genes revealed that 30 Q-type NnZFP genes were expressed in at least one lotus tissue. Nn5g30550 showed relatively higher expression levels in all tested tissues. 12 genes were randomly selected with at least one gene from each phylogenetic clade, and the expression of these selected genes were confirmed by qRT-PCR (quantitative real-time polymerase chain reaction). The results indicated that Q-type NnZFP genes were extensively involved in cadmium, drought, salt and cold stresses responses. Among them, 11 genes responded to at least three different stress treatments, especially Nn2g12894, which induced by all four treatments.

Conclusions
These results could increase our understanding of the characterization of the Q-type NnZFP gene family and provide relevant information for further functional analysis of Q-type NnZFP genes in plant development, and abiotic stress tolerance in lotus.