bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of Polysubstituted Enynes Through Iron‐Catalyzed Carbomagnesiation of Conjugated Diynes.
Authors: Ilies Laurean , Yoshida Takumi , Nakamura Eiichi 
Published: July 2014

AbstractThe carbomagnesiation reaction proceeds on only one triple bond for both symmetrical and unsymmetrical diynes.
ChemInform Abstract: Selective Synthesis of Secondary Amines from Nitriles Using Pt Nanowires as a Catalyst.
Authors: Lu Shuanglong , Wang Jiaqing , Cao Xueqin , Li Xinming , Gu Hongwei 
Published: July 2014

AbstractSymmetrical and unsymmetrical secondary amines are prepared from nitriles in an one‐pot procedure in excellent yields.
ChemInform Abstract: Dihydroindeno[2,1‐c]fluorene‐Based Imide Dyes: Synthesis, Structures, Photophysical and Electrochemical Properties.
Authors: Li Yang‐Yang , Lu Hai‐Yan , Li Meng , Li Xiao‐Jun , Chen Chuan‐Feng 
Published: July 2014

AbstractThe title dyes show strong fluorescence emissions in THF.
ChemInform Abstract: Palladium‐Catalyzed Cyanation of Aryl Bromides with Malononitrile via Carbon—Nitrile Bond Cleavage Mediated by Copper.
Authors: Lu Guo‐ping , Bu Mei‐jie , Cai Chun 
Published: July 2014

AbstractThe cyanation of aryl bromides with malononitrile proceeds by a copper‐mediated cleavage of the carbon‐nitrile bond via a C(sp3) to C(sp2) cyano group transfer process.
ChemInform Abstract: Direct Catalytic Trifluoromethylthiolation of Boronic Acids and Alkynes Employing Electrophilic Shelf‐Stable N‐(Trifluoromethylthio)phthalimide.
Authors: Pluta Roman , Nikolaienko Pavlo , Rueping Magnus 
Published: July 2014

AbstractFor the first time, a safe method for the synthesis of phthalimide (III) which acts as “SCF3” source is developed.
ChemInform Abstract: Palladium on Carbon‐Catalyzed Gentle and Quantitative Combustion of Hydrogen at Room Temperature.
Authors: Monguchi Yasunari , Ida Takashi , Maejima Toshihide , Yanase Takayoshi , Sawama Yoshinari , Sasai Yasushi , Kondo Shin‐ichi , Sajiki Hironao 
Published: July 2014

AbstractH2O2 is formed as an intermediate in a Pd‐C catalyzed quantitative and gentle combustion of hydrogen in the presence of oxygen under normal pressure.
ChemInform Abstract: Palladium‐Catalyzed Desulfitative Direct C—H Arylation of Electron‐Deficient Polyfluoroarenes with Sodium Arenesulfinates.
Authors: Miao Tao , Wang Lei 
Published: July 2014

AbstractHighly fluorinated benzenes and a tetrafluoropyridine (VII) undergo desulfinative Pd(II)‐catalyzed cross‐coupling reactions with arylsulfinates to give fluorinated biaryls in good yields.
ChemInform Abstract: Studies on the Phthalidation of Heteroarenes: A Facile Preparation of 3‐(Heteroaryl)phthalides via Triflic Acid Mediated Phthalidation.
Authors: Nandakumar Meganathan , Sankar Elumalai , Mohanakrishnan Arasambattu K. 
Published: July 2014

AbstractThis straightforward and general method provides access to mono‐, bis‐ and tris‐heteroarylphthalides through triflic acid‐mediated Friedel‐Crafts phthalidations.
ChemInform Abstract: Fe3O4@SiO2—TEMPO as a Magnetically Recyclable Catalyst for Highly Selective Aerobic Oxidation of 5‐Hydroxymethylfurfural into 2,5‐Diformylfuran under Metal‐ and Halogen‐Free Conditions.
Authors: Karimi Babak , Mirzaei Hamid M. , Farhangi Elham 
Published: July 2014

AbstractThe catalyst can be recovered and reused at least five times without significant loss of activity.
ChemInform Abstract: Visible Light Photoredox Catalyzed Cascade Cyclizations of α‐Bromochalcones or α‐Bromocinnamates with Heteroarenes.
Authors: Paria Suva , Reiser Oliver 
Published: July 2014

AbstractThe highly chemoselective and regioselective photocatalyzed cyclization of α‐bromochalcones or α‐bromocinnamates proceeds via vinyl radicals.
ChemInform Abstract: Synthesis of Flavonoids Based Novel Tetrahydropyran Conjugates (Prins Products) and Their Antiproliferative Activity Against Human Cancer Cell Lines.
Authors: Ahmed Naseem , Konduru Naveen Kumar , Ahmad Sarfaraz , Owais Mohammad 
Published: July 2014

AbstractA variety of new, highly functionalized flavonoid based tetrahydropyran derivatives are designed, synthesized and evaluated for their antiproliferative activity.
ChemInform Abstract: Metal‐Free, One‐Pot, Rapid Synthesis of Tetrahydropyridines Using Acetic Acid as Solvent and Catalyst at Room Temperature
Authors: Balijapalli Umamahesh , Munusamy Sathishkumar , Sundaramoorthy Karthikeyan Natesan , Iyer Sathiyanarayanan Kulathu 
Published: July 2014

Abstract36 examples
ChemInform Abstract: Click Chemistry Approach: Regioselective One‐Pot Synthesis of Some New 8‐Trifluoromethylquinoline Based 1,2,3‐Triazoles as Potent Antimicrobial Agents.
Authors: Garudachari B. , Isloor Arun M. , Satyanarayana M. N. , Fun Hoong‐Kun , Hegde Gurumurthy 
Published: July 2014

AbstractThree series of new triazole derivatives (III), (V), (VII) containing a trifluoromethylquinoline nucleus are synthesized using click chemistry, and evaluated for their antimicrobial properties.
ChemInform Abstract: Cobalt‐Catalyzed C‐4 Selective Alkylation of Quinolines.
Authors: Yamamoto Shohei , Saga Yutaka , Andou Takashi , Matsunaga Shigeki , Kanai Motomu 
Published: July 2014

AbstractA C‐4 selective alkylation of quinazolines is achieved using a combination of pyridine, BuLi, and Co(OAc)2.
ChemInform Abstract: α‐Diazo β‐Keto Ester as Precursor to Aromatic C—H Insertion and Wolff Rearrangement with Different Directing Groups.
Authors: Ma Biao , Chen Fang‐Lei , Xu Xing‐Yu , Zhang Yi‐Nan , Hu Li‐Hong 
Published: July 2014

AbstractThe aromatic C‐H insertion and rearrangement of α‐diazo‐β‐keto esters is investigated.
ChemInform Abstract: Rh(III)‐Catalyzed Synthesis of 1‐Substituted Isoquinolinium Salts via a C—H Bond Activation Reaction of Ketimines with Alkynes.
Authors: Senthilkumar Natarajan , Gandeepan Parthasarathy , Jayakumar Jayachandran , Cheng Chien‐Hong 
Published: July 2014

AbstractRuthenium complexes can also be employed as catalysts.
ChemInform Abstract: A Convenient Synthesis of Novel 5‐Aryl‐pyrido[2,3‐d]pyrimidines and Screening of Their Preliminary Antibacterial Properties.
Authors: Saikia Lakhinath , Das Babulal , Bharali Pranjal , Thakur Ashim Jyoti 
Published: July 2014

AbstractA one‐pot version of the catalyst‐free and regioselective synthesis of (V) from (I) with lower yields is also described.
ChemInform Abstract: Iron(III) Chloride/Diorganyl Diselenides Promoted Regio‐ and Stereoselective Cyclization of ortho‐Alkynylanilides: Synthesis of (Z)‐4‐(Chalcogen)methylenebenzoxazines.
Authors: Stein Andre L. , Bilheri Filipe N. , Back Davi F. , Zeni Gilson 
Published: July 2014

AbstractA one‐pot procedure for the preparation of the title compounds is also presented.
ChemInform Abstract: Cytotoxic and Melanogenesis‐Inhibitory Activities of Limonoids from the Leaves of Azadirachta indica (Neem).
Authors: Takagi Mio , Tachi Yosuke , Zhang Jie , Shinozaki Takuro , Ishii Kenta , Kikuchi Takashi , Ukiya Motohiko , Banno Norihiro , Tokuda Harukuni , Akihisa Toshihiro 
Published: July 2014

Abstractisolation, structure elucidation and evaluation of 17 limonoids, including the three novel ones (I), (II), (III), for their cytotoxic activities, their inhibitory activities against melanogenesis in B16 melanoma cells and against the Epstein—Barr virus early antigen
ChemInform Abstract: Tortuosenes A and B, New Diterpenoid Metabolites from the Formosan Soft Coral Sarcophyton tortuosum.
Authors: Lin Kuan‐Hua , Tseng Yen‐Ju , Chen Bo‐Wei , Hwang Tsong‐Long , Chen Hsing‐Yin , Dai Chang‐Feng , Sheu Jyh‐Horng 
Published: July 2014

AbstractThe isolation, structure elucidation and determination of the absolute configuration of the title compounds are described.
ChemInform Abstract: Copper(I) Chloride‐Catalyzed Aerobic Oxidative Arylation of Glycine Ester and Amide Derivatives.
Authors: Huo Congde , Wang Cheng , Wu Mingxia , Jia Xiaodong , Xie Haisheng , Yuan Yong 
Published: July 2014

AbstractA simple copper(I)‐catalyzed process for the selective aerobic oxidative coupling of N‐arylglycine esters and amides at C‐3 of various indoles.
ChemInform Abstract: (‐)‐(2S,3R,Z)‐Nakinadine A: First Asymmetric Synthesis and Absolute Configuration Assignment.
Authors: Davies Stephen G. , Fletcher Ai M. , Roberts Paul M. , Shah Rushabh S. , Thompson Amber L. , Thomson James E. 
Published: July 2014

AbstractThe key step of the 10‐step synthesis of the marine alkaloid (‐)‐(I) is an asymmetric Mannich‐type reaction.
EDF‐based goodness‐of‐fit tests for ranked‐set sampling
Authors: Frey Jesse , Wang Le 
Published: July 2014

AbstractParametric statistical procedures based on ranked‐set sampling are sensitive both to departures from the parametric family and to departures from perfect rankings. In this paper, we develop goodness‐of‐fit tests that are sensitive to departures of both types. These tests are modelled on the Kolmogorov–Smirnov and Cramér–von Mises goodness‐of‐fit tests for simple random sampling, and they take advantage of the fact that under perfect rankings, the cumulative distribution functions (CDFs) for the judgment order statistics are deterministic functions of the population CDF. We consider multiple ways of combining information across the judgment strata, and we find that summing or taking the maximum of separate stratum‐by‐stratum test statistics seems to give the best power. We prove that the best of the proposed tests are consistent against all alternatives.The Canadian Journal of Statistics42: 451–469; 2014 © 2014 Statistical Society of Canada
Lifestyle and metabolic syndrome in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort Study
Authors: Smith Webb A. , Li Chenghong , Nottage Kerri A. , Mulrooney Daniel A. , Armstrong Gregory T. , Lanctot Jennifer Q. , Chemaitilly Wassim , Laver Joseph H. , Srivastava Deo Kumar , Robison Leslie L. , Hudson Melissa M. , Ness Kirsten K. 
Published: July 2014

BACKGROUNDChildhood cancer survivors (CCS) are at an increased risk of developing metabolic syndrome (MetSyn), which may be reduced with lifestyle modifications. The purpose of this investigation was to characterize lifestyle habits and associations with MetSyn among CCS.METHODSCCS who were ≥ 10 years from diagnosis, aged > 18 years, and participating in the St. Jude Lifetime Cohort Study completed medical and laboratory tests and a food frequency questionnaire. The Third Report of the National Cholesterol Education Program Adult Treatment Panel criteria were used to classify participants with MetSyn. Anthropometric, food frequency questionnaire, and self‐reported physical activity data were used to characterize lifestyle habits according to World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) recommendations. Those who met ≥ 4 of 7 recommendations were classified as having followed guidelines. Sex‐stratified log‐binomial regression models were used to evaluate associations between dietary/lifestyle habits and MetSyn, adjusted for age, age at cancer diagnosis, receipt of cranial radiotherapy, education, and household income.RESULTSAmong 1598 CCS (49.2% of whom were male, with a median age of 32.7 years [range, 18.9 years‐60.0 years]), 31.8% met criteria for MetSyn and 27.0% followed WCRF/AICR guidelines. Females who did not follow WCRF/AICR guidelines were 2.4 times (95% confidence interval, 1.7‐3.3) and males were 2.2 times (95% confidence interval, 1.6‐3.0) more likely to have MetSyn than those who followed WCRF/AICR guidelines.CONCLUSIONSAdherence to a heart‐healthy lifestyle is associated with a lower risk of MetSyn among CCS. There is a need to determine whether lifestyle interventions prevent or remediate MetSyn in CCS. Cancer 2014;120:2742–2750. © 2014 American Cancer Society.
p16INK4a overexpression is not linked to oncogenic human papillomaviruses in patients with high‐grade urothelial cancer cells
Authors: Piaton Eric , Casalegno Jean‐Sébastien , Advenier Anne‐Sophie , Decaussin‐Petrucci Myriam , Mege‐Lechevallier Florence , Ruffion Alain , Mekki Yahia 
Published: July 2014

BACKGROUNDp16INK4a Is overexpressed in almost all precancerous and carcinomatous lesions of the uterine cervix, secondary to interference between high‐risk human papillomaviruses (hr‐HPVs) and the retinoblastoma gene product. Overexpression of p16INK4a has also been identified in patients with high‐grade urothelial lesions, both cytologically and histologically. However, the etiological role of HPV has not been documented except in inverted papillomas, low‐grade bladder tumors, and younger patients. We therefore attempted to verify if HPV DNA was detectable in p16INK4a‐positive urothelial tumors.METHODSA total of 90 urinary cytology samples (33 negative/low‐grade cases and 57 high‐grade proliferations) were analyzed for p16INK4a and HPV DNA. HPV genotyping was performed by polymerase chain reaction using a low‐density DNA microarray enabling the detection of 35 HPVs. A reasoned approach combining tissue genotyping and in situ hybridization (ISH) for hr‐HPVs was used in patients with urinary HPV.RESULTSLow‐risk HPV (HPV‐84) and hr‐HPVs (HPV‐16, ‐31, and ‐70) were detected. The prevalence of hr‐HPVs in the urine was low: 5 of 82 patients (6.1%) and only 4 of 50 patients (8.0%) with high‐grade urothelial malignancy. p16INK4a overexpression was noted in 49 high‐grade samples (85.9%). In patients with p16INK4a‐positive tumor cells and hr‐HPV in the urine, HPV genotyping and ISH for hr‐HPVs were negative in matched tissue sections.CONCLUSIONSOur study shows a low prevalence of hr‐HPVs in the urine of patients with high‐grade urothelial malignancy. In those, p16INK4a overexpression occurs in the absence of demonstrable HPV DNA in the tissue sections, contrary to what is noted in gynecopathology. Cancer (Cancer Cytopathol) 2014;122:760–769. © 2014 American Cancer Society.
Lithium–Air Oxygen Shuttle Battery with a ZrO2‐Based Ion‐Conducting Oxide Electrolyte
Authors: Inoishi Atsushi , Matsuka Maki , Sakai Takaaki , Ju Young‐Wan , Ida Shintaro , Ishihara Tatsumi 
Published: July 2014

AbstractA lithium–air battery based on the concept of an “oxygen shuttle” with a calcium‐stabilized ZrO2 electrolyte is described. The observed open‐circuit voltage and discharge capacity are 1.81 V and 2179 mAh per gram of lithium, respectively, at 1073 K. When considering the transport number of an oxide ion at P in an anode chamber, the observed open‐circuit voltage is reasonable. The internal resistance of the lithium–air battery has been analyzed with complex impedance, and the main internal resistance is anodic overpotential because of the platinum electrode used. After discharge, a much larger diffusion resistance, which may suggest surface oxidation of lithium, is observed. However, the observed anodic overpotential is similar to that in a magnesium–air cell reported previously, and much smaller than that of the H2–air fuel cell.
Au–Co3O4/C as an Efficient Electrocatalyst for the Oxygen Evolution Reaction
Authors: Li Zhuo‐ying , Ye Kai‐hang , Zhong Qi‐sui , Zhang Chan‐juan , Shi Shu‐ting , Xu Chang‐wei 
Published: July 2014

AbstractCarbon black that is introduced into Co3O4 will reduce the overpotential of the oxygen evolution reaction. By adding Au, the Co3O4/C catalyst exhibits superior electrochemical activity and excellent stability for the oxygen evolution reaction. The catalyst with a weight ratio of Au to Co3O4 of 1:3 gives the best performance. After loading with Au, the binding energy value of Co 2p has a positive shift, which will increase formation of CoIV cations of the active centers.
Higher titers of anti‐Chlamydia pneumoniae IgG in diabetic retinopathy: a cross‐sectional study
Authors: Banaee Touka , Daneshvar Kakhki Ramin , Abrishami Mojtaba , Mahmoudi Mahmoud , Farzadnia Mehdi 
Published: July 2014

AbstractBackgroundChronic inflammation has a role in the pathogenesis of diabetic retinopathy. Infection with intracellular organisms may incite chronic inflammation. This study was conducted to investigate the association between previous infection with Chlamydia pneumoniae (an intracellular microorganism) and diabetic retinopathy.MethodsPatients with type 2 diabetes mellitus (30–60 years old) and age‐matched normal controls were recruited. Patients with history of cardiovascular or cerebrovascular disease, recent pulmonary infection and the presence of age‐related macular degeneration were excluded from the study. Complete ophthalmic examinations were performed. Fasting blood sugar and haemoglobin levels were measured in diabetic patients and controls, and HgbA1c, blood urea nitrogen, creatinine and 24‐h urine protein were measured in diabetic patients. Anti‐C. pneumoniae IgG (enzyme‐linked immunosorbent assay) was measured in the sera of all participants.ResultsA total of 215 type 2 diabetic patients and 243 normal healthy controls were included. Anti‐C. pneumoniae IgG titers were higher in patients affected by diabetic retinopathy than participants without retinopathy (74.78 ± 33.38 vs 66.18 ± 31.40, p = 0.028). Diabetic patients with diabetic retinopathy also had higher titers than diabetic patients without diabetic retinopathy (74.78 ± 33.38 vs 66.11 ± 33.41, p = 0.042). Of different variables including age, body mass index, haemoglobin level, glycated haemoglobin level, fasting blood sugar, mean arterial pressure and blood urea nitrogen, only age (r = 0.17; p = 0.001) and body mass index (r = 0.15; p = 0.003) were correlated with anti‐C. pneumoniae IgG levels. In regression analysis, the presence of diabetic retinopathy was still a determinant of the antibody level (p = 0.03).ConclusionAnti‐C. pneumoniae IgG titers were higher in patients with diabetic retinopathy, which may indicate a role of this infection in the pathogenesis of diabetic retinopathy. Copyright © 2014 John Wiley & Sons, Ltd.
Adolescent TBI‐induced hypopituitarism causes sexual dysfunction in adult male rats
Authors: Greco Tiffany , Hovda David A. , Prins Mayumi L. 
Published: July 2014

ABSTRACTAdolescents are at greatest risk for traumatic brain injury (TBI) and repeat TBI (RTBI). TBI‐induced hypopituitarism has been documented in both adults and juveniles and despite the necessity of pituitary function for normal physical and brain development, it is still unrecognized and untreated in adolescents following TBI. TBI induced hormonal dysfunction during a critical developmental window has the potential to cause long‐term cognitive and behavioral deficits and the topic currently remains unaddressed. The purpose of this study was to determine if four mild TBIs delivered to adolescent male rats disrupts testosterone production and adult behavioral outcomes. Plasma testosterone was quantified from 72 hrs preinjury to 3 months postinjury and pubertal onset, reproductive organ growth, erectile function and reproductive behaviors were assessed at 1 and 2 months postinjury. RTBI resulted in both acute and chronic decreases in testosterone production and delayed onset of puberty. Significant deficits were observed in reproductive organ growth, erectile function and reproductive behaviors in adult rats at both 1 and 2 months postinjury. These data suggest adolescent RTBI‐induced hypopituitarism underlies abnormal behavioral changes observed during adulthood. The impact of undiagnosed hypopituitarism following RTBI in adolescence has significance not only for growth and puberty, but also for brain development and neurobehavioral function as adults. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 75: 193–202, 2015
Reversed brain size sexual dimorphism accompanies loss of parental care in white sticklebacks
Authors: Samuk Kieran , Iritani Davis , Schluter Dolph 
Published: July 2014

AbstractUncovering factors that shape variation in brain morphology remains a major challenge in evolutionary biology. Recently, it has been shown that brain size is positively associated with level of parental care behavior in various taxa. One explanation for this pattern is that the cognitive demands of performing complex parental care may require increased brain size. This idea is known as the parental brain hypothesis (PBH). We set out to test the predictions of this hypothesis in wild populations of threespine stickleback (Gasterosteus aculeatus). These fish are commonly known to exhibit (1) uniparental male care and (2) sexual dimorphism in brain size (males>females). To test thePBH, we took advantage of the existence of closely related populations of stickleback that display variation in parental care behavior: common marine threespine sticklebacks (uniparental male care) and white threespine sticklebacks (no care). To begin, we quantified genetic differentiation among two common populations and three white populations from Nova Scotia. We found overall low differentiation among populations, althoughFSTwas increased in between‐type comparisons. We then measured the brain weights of males and females from all five populations along with two additional common populations from British Columbia. We found that sexual dimorphism in brain size is reversed in white stickleback populations: males have smaller brains than females. Thus, while several alternatives need to be ruled out, thePBHappears to be a reasonable explanation for sexual dimorphism in brain size in threespine sticklebacks.
Historical and recent processes shaping the geographic range of a rocky intertidal gastropod: phylogeography, ecology, and habitat availability
Authors: Fenberg Phillip B. , Posbic Karine , Hellberg Michael E. 
Published: July 2014

AbstractFactors shaping the geographic range of a species can be identified when phylogeographic patterns are combined with data on contemporary and historical geographic distribution, range‐wide abundance, habitat/food availability, and through comparisons with codistributed taxa. Here, we evaluate range dynamism and phylogeography of the rocky intertidal gastropodMexacanthina lugubris lugubrisacross its geographic range – the Pacific coast of the Baja peninsula and southernCalifornia. We sequenced mitochondrialDNA(CO1) from ten populations and compliment these data with museum records, habitat availability and range‐wide field surveys of the distribution and abundance ofM. l. lugubrisand its primary prey (the barnacleChthamalus fissus). The geographic range ofM. l. lugubriscan be characterized by three different events in its history: an old sundering in the mid‐peninsular region of Baja (~ 417,000 years ago) and more recent northern range expansion and southern range contraction. The mid‐peninsular break is shared with many terrestrial and marine species, althoughM. l. lugubrisrepresents the first mollusc to show it. This common break is often attributed to a hypothesized ancient seaway bisecting the peninsula, but forM. l. lugubrisit may result from large habitat gaps in the southern clade. Northern clade populations, particularly near the historical northern limit (prior to the 1970s), have high local abundances and reside in a region with plentiful food and habitat – which makes its northern range conducive to expansion. The observed southern range contraction may result from the opposite scenario, with little food or habitat nearby. Our study highlights the importance of taking an integrative approach to understanding the processes that shape the geographic range of a species via combining range‐wide phylogeography data with temporal geographic distributions and spatial patterns of habitat/food availability.