bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of ERK1/2 in the regulation of proliferation and differentiation of astrocytes in developing brain
Authors: Cheng Peipei , Alberts Ian , Li Xiaohong 
Published: October 2013

AbstractExtracellular signal regulated kinases (ERK) are important components of the Ras‐Raf‐MEK‐ERK signaling pathway cascades that mediate intracellular stimuli transduction and gene expression. ERK1 (44 kDa) and ERK2 (42 kDa) are homologous subtypes of the ERK family, which participate in regulation of a variety of cell activities, including cell proliferation, migration and differentiation, especially in the central nervous systerm (CNS). Hence, they exert critical effects on neuron and astrocyte development. Astrocytes are critically involved in maintaining CNS homeostasis and supporting neuron growth. When exposed to an extracellular stimulus, such as inflammation or oxidative stress, the corresponding cell response can be regulated by the ERK1/2 signaling pathway. Furthermore, several lines of evidence have demonstrated a correlation between astrocyte activity and the Ras‐Raf‐MEK‐ERK signaling pathway. However many questions remain unanswered regarding the role of ERK1/2 in astrocyte development. This review summarizes the possible role of ERK1/2 signaling cascades in modulating the proliferation, differentiation and apoptosis of astrocytes in both physiological and pathological conditions. In addition, this review also briefly elucidates the participation of ERK1/2 in the process of human brain glia tumor oncogenesis and metastasis, which will provide some concepts for treatment strategies to delay the process of tumor evolution.
Non‐neuronal cell responses differ between normal and Down syndrome developing brains
Authors: Kanaumi Takeshi , Milenkovic Ivan , Adle‐Biassette Homa , Aronica Eleonora , Kovacs Gabor G. 
Published: October 2013

AbstractDown syndrome (DS), the most common genetic cause of mental retardation, is characterized by reduced number of neurons and delayed myelination. Though non‐neuronal cells in the brain are vital for the development, survival, and function of neurons, there is a paucity of comparative studies of normal development and DS, in particular in the temporal lobe, a region of interest for cognitive decline. We evaluated immunoreactivity for CD68 (macrophage), HLA‐DR (microglia), Olig2 and TPPP/p25 (oligodendroglia), and GFAP (astroglia) in the germinal matrix (GM), temporal lobe white matter (TeWM) and hippocampus from 14 weeks of gestations to newborn in 28 DS patients and 30 age‐matched controls. The rate of increase of CD68 positive cells in the GM, CA1 hippocampal subregion and subiculum was significantly higher in DS. The density of Olig2 positive cells in the GM was lower in DS brains at early stages, then showed a transient increase contrasting controls. Olig2 expression increased more in the TeWM in DS, suggesting an altered pattern of oligodendrocyte progenitor generation. GFAP‐immunoreactivity in DS was significantly lower in the middle pregnancy period in the TeWM and did not increase between early and middle periods in the GM compared to controls, likely reflecting a defect in astrocyte production. The altered expression of non‐neuronal cell markers during normal development and DS may play a role in, or reflect, defective neurogenesis, leading to reduced number of neurons and delayed myelination in the developing DS brain. This has implications for the understanding of the mental retardation in DS patients.
RATIONAL GROUP ACTIONS ON AFFINE PI-ALGEBRAS
Authors: LORENZ MARTIN 
Published: October 2013

AbstractLetRbe an affine PI-algebra over an algebraically closed field$\mathbb{k}$and letGbe an affine algebraic$\mathbb{k}$-group that acts rationally by algebra automorphisms onR. ForRprime andGa torus, we show thatRhas only finitely manyG-prime ideals if and only if the action ofGon the centre ofRis multiplicity free. This extends a standard result on affine algebraicG-varieties. Under suitable hypotheses onRandG, we also prove a PI-version of a well-known result on spherical varieties and a version of Schelter's catenarity theorem forG-primes.
Social norms and reference points: integrating sociology and ecology
Authors: MANNING ROBERT E. 
Published: October 2013

SUMMARYReference points are an approach to defining the thresholds of sustainable human use of environmental resources. The rationale for reference points can be found in a number of foundational environmental frameworks, including common property resources, carrying capacity, ecosystem management, and sustainability. However, these frameworks also suggest that reference points have both ecological and social components, and that formulation of reference points should be informed by society. Social norms, developed in sociology, offer a theoretical and empirical approach to informing reference points and have been useful in defining, measuring and managing the sustainability of parks and protected areas. Integrating sociology and ecology through the application of social norms to reference points may be a useful approach to environmental management. This paper describes social norms and their application, and illustrates the integration of sociology and ecology to more fully inform reference points.
The increasing application of multiplex nucleic acid detection tests to the diagnosis of syndromic infections
Authors: GRAY J. , COUPLAND L. J. 
Published: October 2013

SUMMARYOn 14 January 2013, the US Food and Drug Administration (FDA) announced permission for a multiplex nucleic acid test, the xTAG®Gastrointestinal Pathogen Panel (GPP) (Luminex Corporation, USA), which simultaneously detects 11 common viral, bacterial and parasitic causes of infectious gastroenteritis, to be marketed in the USA. This announcement reflects the current move towards the development and commercialization of detection technologies based on nucleic acid amplification techniques for diagnosis of syndromic infections. We discuss the limitations and advantages of nucleic acid amplification techniques and the recent advances in Conformité Européene – in-vitrodiagnostic (CE-IVD)-approved multiplex real-time PCR kits for the simultaneous detection of multiple targets within the clinical diagnostics market.
Enhanced surveillance for toxoplasmosis in England and Wales, 2008–2012
Authors: HALSBY K. , GUY E. , SAID B. , FRANCIS J. , O'CONNOR C. , KIRKBRIDE H. , MORGAN D. 
Published: October 2013

SUMMARYA report on Toxoplasma gondii by the UK Advisory Committee on the Microbiological Safety of Food recommended that more accurate figures on the burden of disease in the UK are needed. We present the first 5 years of data from an enhanced surveillance scheme for toxoplasmosis in England and Wales. Between 2008 and 2012, 1824 cases were reported, with an average of 365 each year. There were 1109 immunocompetent cases, the majority presenting with lymphadenopathy, and 364 immunosuppressed cases, with central nervous system and systemic symptoms most frequently reported. There were also 190 pregnant and 33 congenital cases. Of the pregnant cases, 148 were asymptomatic (probably detected during screening), while 28 suffered a fetal loss or stillbirth. The enhanced surveillance system has led to an improvement in the detection of toxoplasmosis in England and Wales. However, numbers are still likely to be an underestimate, biasing towards the more severe infections.
Knowledge, attitudes, and practices regarding rabies in Filipinos following implementation of the Bohol Rabies Prevention and Elimination Programme
Authors: DAVLIN S. L. , LAPIZ S. M. , MIRANDA M. E. , MURRAY K. O. 
Published: October 2013

SUMMARYKnowledge, attitudes, and practices (KAP) regarding rabies in Bohol, Philippines were assessed following introduction of the Bohol Rabies Prevention and Elimination Programme. A cross-sectional questionnaire was administered to 460 households chosen utilizing the WHO's Expanded Programme on Immunization coverage cluster survey technique with population proportionate to size. Scores for KAP were evaluated using linear regression. The majority of households had heard of rabies (94%); however, specific knowledge of rabies was limited. Only 18% knew to report a suspected rabid dog to the authorities. In multivariate analyses, having known someone with rabies had the greatest effect on knowledge scores. Employment (professional or non-professional) had the greatest effect on attitudes scores, and only the knowledge score was significantly associated with higher practices scores. Several factors, notably, personal experience with rabies, affect KAP in Bohol. The programme should continue to focus on education and include personal accounts to underscore why rabies prevention and control is so important.
The Short-Term “Bridge Model” Study Abroad Program: Peacebuilding in Latin America
Authors: Pugh Jeffrey D. 
Published: October 2013

AbstractThe conventional wisdom about political science international education assumes that students choose between short “island” study abroad programs that are accessible but have only superficial impact, and longer immersion programs, achieving a greater effect. This article argues that well-designed study abroad programs can combine the best of both models to achieve significant impact even in a short program. It proposes a “bridge model” for reconceptualizing study abroad not as a discrete event with more or less impact on student learning, but as a key intervention that furthers a student's overall development within an internationalized curriculum. The article examines the case of a peacebuilding study abroad program in Ecuador. It measures alumni perceptions of impact, objective outcomes, and alumni network development. The key finding is that solid program design and structured cross-cultural interaction produces the type of long-term effect and networks traditionally associated with immersion programs.
Support at Any Distance? The Role of Location and Prejudice in Public Opposition to the “Ground Zero Mosque”
Authors: Schaffner Brian F. 
Published: October 2013

AbstractIn 2010, a debate erupted about plans to construct a mosque (as part of a larger multicultural center) approximately two blocks from Ground Zero in New York City. The main justification given by those who opposed the mosque was that building it so close to Ground Zero would appear to be insensitive. Public opinion appeared to support this notion, as large majorities of Americans registered their opposition to the mosque in surveys conducted at the time. In this article, I examine whether distance was, in fact, an important factor influencing citizens' opposition to the mosque. Using a survey experiment, I asked for opinions on the building of a mosque while randomizing how far the mosque was located from Ground Zero. Results from the experiment indicate that opposition to the mosque was unaffected by how far the mosque would be located from Ground Zero, but strongly influenced by factors such as partisanship, ideology, and tolerance for out groups.
Promoting Student Learning and Scholarship through Undergraduate Research Journals
Authors: Mariani Mack , Buckley Fiona , Reidy Theresa , Witmer Richard 
Published: October 2013

AbstractPrevious research indicates that undergraduate research activities promote student-faculty collaborations and have a positive impact on students, faculty, and institutions. A review of 13 active undergraduate political science journals indicates that these publications take a variety of approaches in format, frequency, and submission requirements. Further, a survey of undergraduate political science journal editors shows that the role of students and faculty and the sources of support for journal publication vary considerably. Finally, case studies of the undergraduate journal experience at three different institutions suggest that political science journals promote student engagement and student-faculty collaboration.
Active Learning Strategies for Diverse Learning Styles: Simulations Are Only One Method
Authors: Bromley Pam 
Published: October 2013

AbstractAlthough political science instructors increasingly recognize the advantages of incorporating active learning activities into their teaching, simulations remain the discipline's most commonly used active learning method. While certainly a useful strategy, simulations are not the only way to bring active learning into classrooms. Indeed, because students have diverse learning styles—comprised of their discrete learning preferences—engaging them in a variety of ways is important. This article explores six active learning techniques: simulations, case studies, enhanced lectures, large group discussion, small group work, and in-class writing. Incorporating these activities into an introductory, writing-intensive seminar on globalization and surveying students about their engagement with course activities, I find that different activities appeal to students with different learning preferences and that simulations are not students most preferred activity. Bringing a broader range of active learning strategies into courses can improve teaching for all students, no matter their learning style.
A Contractualist Reading of Kant's Proof of the Formula of Humanity
Authors: Cureton Adam 
Published: October 2013

AbstractKant offers the following argument for the formula of humanity (FH): Each rational agent necessarily conceives of her own rational nature as an end in itself and does so on the same grounds as every other rational agent, so all rational agents must conceive of one another's rational nature as an end in itself. As it stands, the argument appears to be question-begging and fallacious. Drawing on resources from the formula of universal law (FUL) and Kant's claims about the primacy of duties to oneself, I propose a contractualist reconstruction of this puzzling line of reasoning.
Kant's Argument for the Principle of Intensive Magnitudes
Authors: Jankowiak Tim 
Published: October 2013

AbstractIn the firstCritique,Kant attempts to prove what we can call the ‘principle of intensive magnitudes’, according to which every possible object of experience will possess a determinate ‘degree’ of reality. Curiously, Kant argues for this principle by inferring from a psychological premise about internal sensations (they have intensive magnitudes) to a metaphysical thesis about external objects (they also have intensive magnitudes). Most commentators dismiss the argument as a failure. In this article I give a reconstruction of Kant's argument that attempts to rehabilitate the argument back into his broader transcendental theory of experience. I argue that we can make sense of the argument's central inference by appeal to Kant's theory of empirical intuition and by an analysis of the way in which Kant thinks sensory matter constitutes our most basic representations of objects.
George Reginald Balleine: Historian of Anglican Evangelicalism
Authors: Atherstone Andrew 
Published: October 2013

AbstractA History of the Evangelical Party in the Church of England(1908) by G.R. Balleine (1873–1966) is the classic narrative history of the Anglican evangelical movement, still enduringly popular more than a century after its publication. It has long outlived its author but is usually read without reference to him. This paper examines Balleine's approach to historical research and demonstrates how his personal theological priorities shaped hisHistory. In particular, it highlights his concerns in his parish ministry in Bermondsey, south London, for innovative evangelism, political activism and loyal Anglican churchmanship; his disinterest in doctrinal definitions and his abhorrence of ecclesiastical controversy. The paper argues that Balleine's lively account of Anglican evangelicalism's past in the eighteenth and nineteenth centuries was also an apologia and mandate for the future direction of the movement as it entered the twentieth century. It concludes by pointing to the sharp irony that while theHistoryhas gained a reputation for impeccable evangelical credentials, the historian was on a divergent trajectory away from his evangelical roots.
A new taxonomic arrangement for Paleorhinus scurriensis
Authors: Stocker Michelle R. 
Published: October 2013

ABSTRACTThe paraphyletic genus ‘Paleorhinus’ is understood currently as a cosmopolitan phytosaur taxon from the Late Triassic. There is no consensus regarding the number of species of ‘Paleorhinus,’ with multiple species and genera synonymised into a single genus or even a single species at various points in its published history. The taxonomy is confounded by historical descriptions without the benefit of comparisons to more recently collected specimens, emphasis on plesiomorphic cranial morphology as diagnostic features of the genus, and lack of cladistic analyses. When included in a recent explicitly cladistic phylogenetic analysis, the holotype of ‘Paleorhinus’ scurriensis (TTU P-00539) was found to be the earliest-branching phytosaur with respect to other North American specimens previously referred to ‘Paleorhinus,’ and is generically distinct from Paleorhinus. ‘Paleorhinus’ scurriensis differs from all known phytosaurs in five unambiguous characters: basitubera widely separated mediolaterally; ridge present on lateral surface of jugal; thickened shelf present along posteroventral edge of expanded pterygoid-quadrate wing; ‘septomaxillae’ separated and excluded from internarial septum; and nasal swelling present posterior to posterior borders of nares. This detailed morphological description of an early-branching phytosaur taxon is a first step towards resolving long-standing issues surrounding specific anatomical features and relationships among early members of the clade.
Delayed detection of climate mitigation benefits due to climate inertia and variability
Authors: Tebaldi Claudia , Friedlingstein Pierre 
Published: October 2013

Significance
One of the benefits of climate mitigation policies is the reduction of future warming. Here, we estimate the time at which we can detect the mitigation signal arising from reducing future emissions of greenhouse gases. Estimation of detection time is inherently a signal-to-noise issue, requiring consideration of uncertainties in both internal variability and model responses to anthropogenic influences. We provide detection times in terms of best estimates and uncertainty ranges. Our study addresses the critical question of how long we may need to wait until we can clearly identify the benefits (in terms of avoided warming) of different mitigation pathways. This question is not only of scientific relevance, but it is also of direct concern to policymakers and the public.
Work–family conflict, health services and medication use among dual‐income couples in Europe
Authors: Christiaens Wendy , Bracke Piet 
Published: October 2013

AbstractCombination pressure or work–life imbalance is linked to adverse health. However, it remains unclear how work–family conflict is related to healthcare utilisation. Does work–family conflict function as a barrier or as a facilitator in relation to the use of health services and prescription medication? Lack of time may prevent people from visiting a doctor when they feel unwell. However, combination pressure can also be expected to intensify the use of health services, as the need for a quick fix is prioritised. Further, do women and men differ in their susceptibility to medicalisation and time pressure resulting from work–life imbalance? This article investigates the use of health services and prescription medication of dual‐income couples with children, based on data from 23 countries in the European Social Survey round 2 (Nwomen = 3755; Nmen = 3142). It was found that medical services and prescription medications are used more frequently in dual‐income couples experiencing work‐to‐family spillover, but for women only this is irrespective of their self‐reported health. Family‐to‐work spillover does not result in increased health service or medication use for either men or women. While women opt for a medical response to work–life imbalance, men's reluctance to seek formal health support is confirmed.
Defining an epidemic: the body mass index in British and US obesity research 1960–2000
Authors: Fletcher Isabel 
Published: October 2013

AbstractBetween the 1970s and the mid‐1990s the body mass index (BMI) became the standard means of assessing obesity both in populations and in individuals, replacing previously diverse and contested definitions of excess body weight. This article draws on theoretical approaches from the sociology of standards and science and technology studies to describe the development of this important new standard and the ways in which its adoption facilitated the development of obesity science, that is, knowledge about the causes, health effects and treatments of excess body weight. Using an analysis of policy and healthcare literatures, I argue that the adoption of the BMI, along with associated standard cut‐off points defining overweight and obesity, was crucial in the framing of obesity as an epidemic. This is because, I suggest, these measures enabled, firstly, the creation of large data sets tracking population‐level changes in average body weight, and, secondly, the construction of visual representations of these changes. The production of these two new techniques of representation made it possible for researchers in this field, and others such as policymakers, to argue credibly that obesity should be described as an epidemic.
Complexities and contingencies conceptualised: towards a model of reproductive navigation
Authors: van der Sijpt Erica 
Published: October 2013

AbstractCurrent international attention to reproductive health behaviour is inspired by a western celebration of individual rights, autonomous action and rational choice. A predominant idea is that individuals should be free to act in accordance with their reproductive intentions and that, in doing so, they will attain their desired (and quantifiable) fertility outcomes. Yet such a framework leads to a misrepresentation of the reproductive dynamics on the ground, because individual fertility intentions are often not a priori defined, decisions are often not the result of rational calculation and reproductive happenings do not exist in a social vacuum. This article provides sociocultural evidence for a different conceptualisation of reproductive health behaviour. On the basis of long‐term anthropological fieldwork in the East Province of Cameroon, I will analyse the complexities of fertility‐related decision‐making. Two case studies from the field will show that reproductive happenings are often characterised by indeterminacy and contingency. In order to understand the complex ways in which women give direction to these uncertainties, I propose an encompassing framework of reproductive navigation that explicitly acknowledges the influence of sociality and corporeality on fertility aspirations and actions.