bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjuvant Hepatic Intra‐arterial Iodine‐131‐Lipiodol Following Curative Resection of Hepatocellular Carcinoma: A Prospective Randomized Trial
Authors: Chung A. Y. F. , Ooi L. L. P. J. , Machin D. , Tan S. B. , Goh B. K. P. , Wong J. S. , Chen Y. M. , Li P. C. N. , Gandhi M. , Thng C. H. , Yu S. W. K. , Tan B. S. , Lo R. H. G. , Htoo A. M. M. , Tay K. H. , Sundram F. X. , Goh A. S. W. , Chew S. P. , Liau K. H. , Chow P. K. H. , Tay K. H. , Tan Y. M. , Cheow P. C. , Ho C. K. , Soo K. C. 
Published: March 2013

AbstractBackgroundThe purpose of the present study was to determine whether intrahepatic injection of 131I‐lipiodol (Lipiodol) is effective against recurrence of surgically resected hepatocellular carcinoma (HCC).MethodsFrom June 2001 through March 2007, this nationwide multi‐center prospective randomized controlled trial enrolled 103 patients 4–6 weeks after curative resection of HCC with complete recovery (52: Lipiodol, 51: Control). Follow‐up was every 3 months for 1 year, then every 6 months. Primary and secondary endpoints were recurrence‐free survival (RFS) and overall survival (OS), respectively, both of which were evaluated by the Kaplan–Meier technique and summarized by the hazard ratio (HR). The design was based on information obtained from a similar trial that had been conducted in Hong Kong.ResultsThe Lipiodol group showed a small, and nonsignificant, improvement over control in RFS (HR = 0.75; 95 % confidence interval [95 % CI] 0.46–1.23; p = 0.25) and OS (HR = 0.88; 95 % CI 0.51–1.51; p = 0.64). Only two serious adverse events were reported, both with hypothyroidism caused by 131I‐lipiodol and hepatic artery dissection during angiography.ConclusionsThe randomized trial provides insufficient evidence to recommend the routine use of 131I‐lipiodol in these patients.
Lessons for Surgeons in the Final Moments of Air France Flight 447
Authors: Bhangu Aneel , Bhangu Sonia , Stevenson James , Bowley Douglas M. 
Published: March 2013

AbstractBackgroundAll surgeons make mistakes, and learning from critical incidents may help improve performance. The present study aimed to highlight lessons for surgeons from analysis of the final moments of Air France Flight 447. All of the authors work in teams and situations where safety, technical performance, and non‐technical skills are critical. This review was born out of discussions regarding the events of Flight 447; specifically, whether the airline disaster was relevant to their work, and whether they could learn anything from it.MethodsThe study is based on review of the crash reports of Flight 447, which lost flight speed indication after formation of ice prevented air from entering flight speed indicators during a storm. Following a subsequent stall, the aircraft fell at a rate of >10,000 feet/min until it crashed into the Atlantic Ocean, killing 228 passengers and crew.ResultsThere were errors in decision making, reasoning, communication, and teamwork. Such non‐technical skills failures have been recognized previously and can be addressed by existing non‐technical skills training. A reliance on autopilot meant that the pilots were unfamiliar with high‐altitude flying when the autopilot is disengaged. They were unprepared for and affected by such a sudden and serious problem; an event called “surprise and startle” by the accident investigation. The absence of the senior pilot (who was on a scheduled break) in the critical final minutes slowed error recognition and recovery.ConclusionsUnintended consequences of modern safety strategies may be under‐recognized and can lead to adverse events. Both simulation‐based and non‐simulation–based training should include “surprise and startle” events beyond the scenarios trainees might expect. Likewise, in the face of increasing reliance on modern technology, surgeons should ensure that they would be able to perform procedures in the absence of such technologies. Specific training may improve surgeons’ non‐technical skills, and recognition of such skills could also be used to help select future surgeons.
Impact of Skin Grafting of Venous Leg Ulcers on Functional Status and Pain
Authors: Salomé Geraldo Magela , Ferreira Lydia M. 
Published: March 2013

AbstractBackgroundDisability and pain were assessed in patients with venous leg ulcers treated with split‐thickness skin grafts to evaluate to what extent skin grafting improves functional status in this population.MethodsA prospective, nonrandomized, multicenter case–control study was conducted from July 2008 to December 2010 in two hospitals in Brazil. One hundred patients with venous leg ulcers were divided into two treatment groups of 50 patients each: the control group (conservative treatment) and the surgery group (skin grafting). Patients were assessed at baseline (day 0) and on days 30, 90, and 180. Disability was measured with the Disability Index of the Health Assessment Questionnaire (HAQ‐DI). The visual analog scale (VAS) and McGill Pain Questionnaire (MPQ) were used to assess pain.ResultsSurgery group patients reported significantly lower (p = 0.0001) overall HAQ‐DI scores (lower disability levels) 180 days postoperatively (HAQ‐DI = 0.18) compared with baseline (HAQ‐DI = 2.65); mean overall HAQ‐DI scores for control patients was 1.70 on day 180, with a significant difference between groups (p = 0.0001). The surgery group showed significant improvement on all HAQ‐DI categories and reported significantly lower pain intensity (VAS pain scores) on days 30, 90, and 180 compared with controls (p = 0.0001). The MPQ was used to assess the sensory, affective, evaluative, and miscellaneous dimensions of pain in the two groups; there were significant differences between groups on days 30, 90, and 180 (p = 0.0001).ConclusionsPatients with venous leg ulcers treated with split‐thickness skin grafts showed improvement in functional status compared with controls.
Complementary Use of Resection and Radiofrequency Ablation for the Treatment of Colorectal Liver Metastases: An Analysis of 395 Patients
Authors: Agcaoglu Orhan , Aliyev Shamil , Karabulut Koray , El‐Gazzaz Galal , Aucejo Federico , Pelley Robert , Siperstein Allan E. , Berber Eren 
Published: March 2013

AbstractBackgroundLiver resection and radiofrequency ablation (RFA) are two surgical options in the treatment of patients with colorectal liver metastases (CLM). The aim of this study was to analyze patient characteristics and outcomes after resection and RFA for CLM from a single center.MethodsBetween 2000 and 2010, 395 patients with CLM undergoing RFA (n = 295), liver resection (n = 94) or both (n = 6) were identified from a prospective IRB‐approved database. Demographic, clinical and survival data were analyzed using univariate and multivariate analyses.ResultsRFA patients had more comorbidities, number of liver tumors and a higher incidence of extrahepatic disease compared to the Resection patients. The 5‐year overall actual survival was 17 % in the RFA, 58 % in the Resection group (p = 0.001). On multivariate analysis, multiple liver tumors, dominant lesion >3 cm, and CEA >10 ng/ml were independent predictors of overall survival. Patients were followed for a median of 20 ± 1 months. Liver and extrahepatic recurrences were seen in 69 %, and 29 % of the patients in the RFA, and 40 %, and 19 % of the patients in the Resection group, respectively.ConclusionsIn this large surgical series, we described the characteristics and oncologic outcomes of patients undergoing resection or RFA for CLM. By having both options available, we were able to surgically treat a large number of patients presenting with different degrees of liver tumor burden and co‐morbidities, and also manage liver recurrences in follow‐up.
An update on serine deficiency disorders
Authors: van der Crabben S. N. , Verhoeven‐Duif N. M. , Brilstra E. H. , Van Maldergem L. , Coskun T. , Rubio‐Gozalbo E. , Berger R. , de Koning T. J. 
Published: March 2013

AbstractSerine deficiency disorders are caused by a defect in one of the three synthesising enzymes of the L‐serine biosynthesis pathway. Serine deficiency disorders give rise to a neurological phenotype with psychomotor retardation, microcephaly and seizures in newborns and children or progressive polyneuropathy in adult patients. There are three defects that cause serine deficiency of which 3‐phosphoglycerate dehydrogenase (3‐PGDH) deficiency, the defect affecting the first step in the pathway, has been reported most frequently. The other two disorders in L‐serine biosynthesis phosphoserine aminotransferase (PSAT) deficiency and phosphoserine phosphatase (PSP) deficiency have been reported only in a limited number of patients. The biochemical hallmarks of all three disorders are low concentrations of serine in cerebrospinal fluid and plasma. Prompt recognition of affected patients is important, since serine deficiency disorders are treatable causes of neurometabolic disorders. The use of age‐related reference values for serine in CSF and plasma can be of great help in establishing a correct diagnosis of serine deficiency, in particular in newborns and young children.
Deforestation in central Chile causes a rapid decline in landscape connectivity for a forest specialist bird species
Authors: Vergara Pablo M. , Pérez‐Hernández Christian G. , Hahn Ingo J. , Soto Gerardo E. 
Published: March 2013

AbstractThe abundance of woodland birds in fragmented forest landscapes may depend on the properties of patch networks. Understanding the consequences of deforestation on woodland birds, therefore, necessarily requires determining which changes in landscape structure make a major contribution to the degradation and subdivision of patch networks. In this study, we addressed how accelerated deforestation in central Chile has modified the landscape structure and function for thorn‐tailed rayaditos—a woodland specialist bird. Using a graphical approach based on the habitat use and movement patterns of rayaditos, we quantified the reduction of the internal connectivity of components (i.e., connected patch networks) in the last two decades and determined the main mechanisms responsible for this connectivity loss. Forest cover decreased 61.7 % between 1989 and 2009. The component size, the fraction of components with ≥1 occupied patches and the number of patches per component experienced a large decline during the study period. Over time, most forest cover (ca. 80 %) was contained in only two components. The connectivity of components decreased steeply by 90 %. Only the loss of large patches made a highly significant contribution to explaining changes in connectivity, while the removal of stepping stones was marginally significant. The conversion of forest both to shrubland and to peri‐urban areas were the only land‐use variables explaining connectivity change with effects that changed over time. Conservation measures to ensure persistence of rayaditos populations in central Chile should be focused on the retention of key elements for connectivity.
Deformation Pattern and Vein Development in Delhi Supergroup Rocks, Northeastern Part of Delhi-Aravalli Belt: Implication of Late Stage Dilation
Authors: Dinkar G. K. , Gireesh R. V. , Bhola A. M. 
Published: March 2013

Abstract:
The Delhi Supergroup rocks of Mesoproterozoic age in the north-eastern part of Delhi-Aravalli belt are poly-deformed. These rocks show meso and micro-scale stretched quartzo-feldspathic veins in the gneissic rocks in association with marble and amphibolites in contrast to those commonly described from the low grade metamorphic rocks in the northeastern part of the Delhi-Aravalli belt. The textural features of the veins which show stretched crystals in gneisses indicate that these developed in phases episodically in the direction of mineral lineation. The veins occupy tensional cracks without shear component and developed when the fluid pressure was high enough as they form in amphibolite facies of metamorphism.
Mineral Matter and the Nature of Pyrite in Some High-sulfur Tertiary Coals of Meghalaya, Northeast India
Authors: Nayak Bibhuranjan 
Published: March 2013

Abstract:
Coal samples collected from four different sources in the Jaintia Hills of Meghalaya, northeast India, have been investigated for their sulfur content, mineral matter, and to assess their potential behavior upon beneficiation. These coals contain high sulfur which occurs both in organic and inorganic forms. The organic sulfur content is much higher than the inorganic sulfur. Studies on different size and gravity fractions indicated that the mineral phases are concentrated in higher density fractions (d &gt; 1.8) and in general are fine grained (&lt;50 μm). Data of reflected-light optical microscope and electron probe micro-analysis (EPMA) revealed that minerals in these coals are sulfides- pyrite, marcasite, sphalerite, pentlandite; sulfates- barite, jarosite; oxides- hematite, rutile; hydroxides- gibbsite, goethite; phosphate- monazite; carbonate- calcite, siderite and silicates- quartz, mica, chlorite, and kaolinitic clay. The disulfides of iron occur in two modes – mainly pyrite and occasionally marcasite with wide size ranges and in various forms, such as: framboid, colloidal precipitate, colloform-banded, fine disseminations, discrete grains, dendritic (feathery), recrystallized, nuggets, discoidal, massive, cavity-fracture- and cleat-fillings. Framboidal pyrite has formed primarily due to biological activities of sulfur reducing bacteria in the early stages of coalification. Massive and other varieties have formed at later stages due to coalescence and recrystallization of the earlier formed pyrites. Sulfur isotopic values indicate a biogenic origin for the pyrites. Association of trace metals, such as Ni, and Zn has been recorded in these pyrites. Given the large fractions of organic sulfur present, these coals can be upgraded only partially to reduce the sulfur content by beneficiation.
Evaluation and Comparison of GIS based Landslide Susceptibility Mapping Procedures in Kulekhani Watershed, Nepal
Authors: Kayastha Prabin , Dhital Megh Raj , Smedt Florimond De 
Published: March 2013

Abstract:
The goal of this paper is to evaluate and compare the consistency of GIS-based heuristic and bivariate landslide susceptibility mapping techniques in the Himalayan region, taking the Kulekhani watershed of central Nepal as an example. For this purpose, a heuristic and two statistical bivariate landslide susceptibility mapping methods are applied, and three separate landslide susceptibility zonation maps are produced. The maps are compared using three approaches: landslide density analysis, success rate analysis, and agreed area analysis. A comparison of the values obtained from landslide density analysis and the curves of success rate analysis indicate that the two bivariate methods produce almost identical results, whereas the map produced with the heuristic method differs significantly from the others. On the other hand, the agreed area analysis highlights significant spatial differences in the maps obtained from the three methods. Although the three approaches evaluate the consistency of susceptibility maps, only the agreed area analysis is capable of spatially comparing them. Hence, this approach proves to be more suitable for spatially and quantitatively evaluating the consistency of various landslide susceptibility zonation maps.
Role of Transverse Tectonics in the Himalayan Collision: Further Evidences from Two Contemporary Earthquakes
Authors: Dasgupta Sujit , Mukhopadhyay Basab , Mukhopadhyay Manoj , Nandy D. R. 
Published: March 2013

Abstract:
Two contemporary earthquakes originating in the central Himalayan arc and its foredeep (Sikkim earthquake of 18.09.2011, Mw 6.9, h: 10-60 (?) km and Bihar-Nepal earthquake of 20.08.1988, Mw 6.8, h: 57 km) are commonly associated with transverse lineaments/faults traversing the region. Such lineaments/faults form active seismic blocks defining promontories for the advancing Indian Craton. These actually produce conjugate shear faulting pattern suggestive of pervasive crustal interplay deep inside the mountains. Focal mechanism solutions allow inferring that large part of the current convergence across the central Himalayan arc is accommodated by lateral slip. Similar slip also continues unabated in the densely populated foredeep for distances up to several tens of kilometers south of the Main Boundary Thrust (MBT).
Innovation types in the Finnish maritime cluster
Authors: Makkonen Teemu , Inkinen Tommi , Saarni Jouni 
Published: March 2013

Abstract
The Finnish maritime cluster is an important sector of Finland's economy. However, literature on innovative activities within the cluster is limited. This article focuses on Finnish shipbuilding and marine industry firms. Several innovation types are identified. These are analyzed according to general characteristics of firms. The data is from a survey of 148 shipbuilding and marine industry companies; most of the variables are ordinal scale and are analyzed with standard statistical survey methods. Considering the significance and past technological achievements of the sector the results indicate surprisingly low radical innovation related-activity and attitudes towards it. As well, the results provide no evidence to support previous research, suggesting that the shipbuilding and marine industry produces more organizational than technological innovations. The innovativeness of the firms varies according to distinct characteristics such as size, intensity of in-house and collaborative R&D activities, and level of internationalization. The empirical results provide a platform for policy implications and directions for future research; innovations concerning environmental efficiency are raised as an important future area of development.
A curriculum focused on informed empathy improves attitudes toward persons with
disabilities
Authors: Miller Sonya R. 
Published: March 2013

Empathy is an important component of the provider-patient relationship. In the
United States one in five persons has a disability. Persons with disabilities perceive
gaps in health care providers’ understanding of their health care preferences and needs.
The purpose of this study was to use valid and reliable assessment methods to
investigate the association between empathy and attitudes toward persons with
disabilities and advocacy. An educational module was developed to enhance health care
students’ capacity for informed empathy. Pre- and post-assessment measures included the
Attitude toward Disabled Persons scale (ATDP), the Attitudes toward Patient Advocacy
Microsocial scale (AMIA) and the Interpersonal Reactivity Index (IRI). ATDP
(t(94) = −5.95, p = .000) and AMIA (t(92) = −5.99, p = .000) scores increased
significantly after the education module. Correlations between the pre- or post-module
ATDP or AMIA scores and the IRI scores were not significant. Empathy in general may not
be sufficient to ensure optimal attitudes toward persons with disabilities or advocacy
in pre-health care professionals. However, a curriculum based on informed empathy and
focused on the experiences of persons with disabilities can result in more positive
attitudes toward and advocacy for people with disabilities.
Rapid diagnosis of the economically important fruit fly,Bactrocera correcta(Diptera: Tephritidae) based on a species-specific barcoding cytochrome oxidase I marker
Authors: Jiang F. , Li Z.H. , Deng Y.L. , Wu J.J. , Liu R.S. , Buahom N. 
Published: March 2013

AbstractThe guava fruit fly,Bactrocera correcta(Bezzi) (Diptera: Tephritidae), is an invasive pest of fruit and vegetable crops that primarily inhabits Southeast Asia and which has the potential to become a major threat within both the Oriental and Australian oceanic regions as well as California and Florida. In light of the threat posed, it is important to develop a rapid, accurate and reliable method to identifyB. correctain quarantine work in order to provide an early warning to prevent its widespread invasion. In the present study, we describe a species-specific polymerase chain reaction assay for the diagnosis ofB. correctausing mitochondrial DNA cytochrome oxidase I (mtDNA COI) barcoding genes. AB. correcta-specific primer pair was designed according to variations in the mtDNA COI barcode sequences among 14 fruit fly species. The specificity and sensitivity of theB. correcta-specific primer pair was tested based on the presence or absence of a band in the gel profile. A pair of species-specificB. correctaprimers was successfully designed and named BCOR-F/BCOR-R. An ∼280 bp fragment was amplified from specimens belonging to 17 geographical populations and four life stages ofB. correcta, while no such diagnostic bands were present in any of the 14 other related fruit fly species examined. Sensitivity test results demonstrated that successful amplification can be obtained with as little as 1 ng μl−1of template DNA. The species-specific PCR analysis was able to successfully diagnoseB. correcta, even in immature life stages, and from adult body parts. This method proved to be a robust single-step molecular technique for the diagnosis ofB. correctawith respect to potential plant quarantine.
Resistance of αAI-1 transgenic chickpea (Cicer arietinum) and cowpea (Vigna unguiculata) dry grains to bruchid beetles (Coleoptera: Chrysomelidae)
Authors: Lüthi Christoph , Álvarez-Alfageme Fernando , Ehlers Jeffrey D. , Higgins Thomas J.V. , Romeis Jörg 
Published: March 2013

AbstractDry grain legume seeds possessing αAI-1, an α-amylase inhibitor from common bean (Phaseolus vulgaris), under the control of a cotyledon-specific promoter have been shown to be highly resistant to several important bruchid pest species. One transgenic chickpea and four cowpea lines expressing αAI-1, their respective controls, as well as nine conventional chickpea cultivars were assessed for their resistance to the bruchids Acanthoscelides obtectus (Say), Callosobruchus chinensis L. and Callosobruchus maculatus F. All transgenic lines were highly resistant to both Callosobruchus species. A. obtectus, known to be tolerant to αAI-1, was able to develop in all transgenic lines. While the cotyledons of all non-transgenic cultivars were highly susceptible to all bruchids, C. chinensis and C. maculatus larvae suffered from significantly increased mortality rates inside transgenic seeds. The main factor responsible for the partial resistance in the non-transgenic cultivars was deduced to reside in the seed coat. The αAI-1 present in seeds of transgenic chickpea and cowpea lines significantly increases their resistance to two important bruchid pest species (C. chinensis and C. maculatus) essentially to immunity. To control αAI-1 tolerant bruchid species such as A. obtectus and to avoid the development of resistance to αAI-1, varieties carrying this transgene should be protected with additional control measures.
BEEN THERE, DONE THAT, BOUGHT THE T-SHIRT: BEŞIKTAŞ FANS AND THE COMMODIFICATION OF FOOTBALL IN TURKEY
Authors: McManus John 
Published: March 2013

AbstractIn this article, I explore how the rapid commercialism and commodification of Turkish premier league football has affected the activities of a particular fan group, Çarşı, for the club Beşiktaş, one of Turkey's oldest teams. I look at how elements of the commodification of football have been harnessed and mediated by Çarşı to make ethical and political statements and convey an anarcho-socialist message. These processes, I argue, are driven by the possibilities opened up by rapid social and technological development. The shift to searching for identity among the forums and video websites of the internet, rather than on the terraces of Beşiktaş, is profoundly altering how fans construct their allegiance to the fan group and the club. This process, it will be shown, is not so much liberating supporters from the requirements of fandom as it is generating new conventions and processes to which Çarşı members must adhere.