bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Microwave‐Assisted Mild, Rapid, Solventless, and Catalyst‐Free Chemoselective N‐tert‐Butyloxycarbonylation of Amines.
Authors: Dighe Satish N. , Jadhav Hemant R. 
Published: January 2013

AbstractA broad spectrum of substrates including amines, phenyl hydrazine, and amino acid esters can be converted in high yields.
ChemInform Abstract: Palladium‐Catalyzed Mono‐α‐arylation of Acetone with Aryl Imidazolylsulfonates.
Authors: Ackermann Lutz , Mehta Vaibhav P. 
Published: January 2013

AbstractAir‐ and moisture‐stable aryl imidazolylsulfonates are established as nongenotoxic, user‐friendly electrophiles for α‐arylation of ketones.
ChemInform Abstract: Remarkable Improvement Achieved by Imidazole Derivatives in Ruthenium‐Catalyzed Hydroesterification of Alkenes Using Formates.
Authors: Konishi Hideyuki , Ueda Tsuyoshi , Muto Takashi , Manabe Kei 
Published: January 2013

AbstractThe synthesis proceeds without a directing group, toxic CO gas or large excess of alkene.
ChemInform Abstract: Synthesis of Alkyl Bis(dimethylamino)methylenecarbamodithioates from 1,1,3,3‐Tetramethylguanidine, CS2 and Oxiranes.
Authors: Yavari Sima , Nasiri‐Gheidari Samira , Taherpour Avat , Yavari Issa 
Published: January 2013

AbstractA simple one‐pot three‐component reaction allows the synthesis of the title compounds (IV) and (VI).
ChemInform Abstract: Asymmetric Hydroalkynylation of Norbornadienes Promoted by Chiral Iridium Catalysis.
Authors: Fan Bao‐Min , Yang Qing‐jing , Hu Jun , Fan Cai‐ling , Li Si‐feng , Yu Lu , Huang Chao , Tsang Wing Wai , Kwong Fuk Yee 
Published: January 2013

AbstractThe reaction of substituted norbornene derivatives with aromatic and aliphatic terminal alkynes proceeds with high level of enantioselectivities and tolerates a wide range of functional groups.
ChemInform Abstract: Fluoroform‐Derived CuCF3 for Low‐Cost, Simple, Efficient, and Safe Trifluoromethylation of Aryl Boronic Acids in Air.
Authors: Novak Petr , Lishchynskyi Anton , Grushin Vladimir V. 
Published: January 2013

AbstractThe reaction is effective for aromatic and heteroaromatic boronic acids and is not sensitive to electronic and steric effects.
ChemInform Abstract: Mn(OAc)2/Schiff Base as a New Efficient Catalyst System for the Henry Reaction of Nitroalkanes with Aldehydes.
Authors: Zhou Guang Peng , Hui yong Hai , Wan Ning Ning , Liu Qiu Ju , Xie Zheng Feng , Wang Ji De 
Published: January 2013

AbstractReaction of nitromethane with aromatic aldehydes produces the corresponding β‐nitro alcohols with good to excellent yields, whereas only moderate yields are obtained for aliphatic substrates.
ChemInform Abstract: Visible‐Light‐Promoted C—C Bond Cleavage: Photocatalytic Generation of Iminium Ions and Amino Radicals.
Authors: Cai Shunyou , Zhao Xinyang , Wang Xinbo , Liu Qisong , Li Zigang , Wang David Zhigang 
Published: January 2013

AbstractSimple vicinal diamines as new precursors of photoexcited radical cations are employed in the title reaction under exceptionally mild reaction conditions.
ChemInform Abstract: Oxidative Dimerization of Aromatic Amines Using tBuOI: Entry to Unsymmetric Aromatic Azo Compounds.
Authors: Takeda Youhei , Okumura Sota , Minakata Satoshi 
Published: January 2013

AbstractHomo‐ and cross‐dimerization of the aromatic and heteroaromatic amines is achieved using tBuOI, generated in situ, to afford symmetric and unsymmetric aromatic azo compounds in good yields.
ChemInform Abstract: Unexpected Palladium‐Catalyzed O‐Arylation Occurring in 4‐(4‐Fluoro‐3‐nitrophenyl)‐1,2‐dimethyl‐5‐nitro‐1H‐imidazole Series.
Authors: Zink Laura , Neilde Kevin , Crozet Maxime D. , Vanelle Patrice 
Published: January 2013

AbstractThe fluoro‐substituted starting material (I) reacts with arylboronic acids under Suzuki—Miyaura conditions to give O‐arylated products (III) instead of the expected C—C coupled compounds, required in pharmaceutical investigation.
ChemInform Abstract: Double Nucleophilic N‐Alkylation of α‐Oxime‐esters with Grignard Reagents.
Authors: Mizutani Yusuke , Tanimoto Hiroki , Morimoto Tsumoru , Nishiyama Yasuhiro , Kakiuchi Kiyomi 
Published: January 2013

AbstractThe reaction produces N,N‐dialkyl‐α‐amino esters in good yields.
ChemInform Abstract: A Novel Approach for the Synthesis of α‐Aminonitriles Using Mitsunobu′s Reagent under Solvent‐Free Conditions.
Authors: Chaturvedi Devdutt , Chaturvedi Amit K. , Mishra Nisha , Mishra Virendra 
Published: January 2013

AbstractThe new procedure allows the preparation of a broad spectrum of the biologically important title compounds (40 examples).
ChemInform Abstract: Bu4NI‐Catalyzed Benzylic Acyloxylation of Alkylarenes with Aromatic Aldehydes.
Authors: Huang Juan , Li Lan‐Tao , Li Hong‐Ying , Husan Ezizjan , Wang Peng , Wang Bin 
Published: January 2013

AbstractA metal‐free approach for the direct acyloxylation of benzylic C—H bonds using aromatic aldehydes (II) under mild conditions is reported.
ChemInform Abstract: BF3·Et2O‐Promoted Conjugate Addition of Ethanethiol to Electron‐Deficient Alkynes.
Authors: Zhou Qing Fa , Chu Xue Ping , Zhao Shen , Lu Tao , Tang Wei Fang 
Published: January 2013

AbstractThe synthesis of vinyl thioethers is achieved through conjugate addition of (II) to alkynes under optimized conditions.
ChemInform Abstract: Solvent‐Free Heck and Copper‐Free Sonogashira Cross‐Coupling Reactions Catalyzed by a Polystyrene‐Anchored Pd(II) Phenyldithiocarbazate Complex.
Authors: Bakherad Mohammad , Keivanloo Ali , Samangooei Shahrzad 
Published: January 2013

AbstractThe novel catalyst produces generally high yields in both processes starting from either aryl iodides or bromides.
ChemInform Abstract: Organocatalytic Asymmetric Direct C(sp3)—H Functionalization of Ethers: A Highly Efficient Approach to Chiral Spiroethers.
Authors: Jiao Zhi‐Wei , Zhang Shu‐Yu , He Chuan , Tu Yong‐Qiang , Wang Sho‐Hua , Zhang Fu‐Min , Zhang Yong‐Qiang , Li Hui 
Published: January 2013

AbstractCyclic ethers containing an α,β‐unsaturated aldehyde moiety undergo an imidazolidinone/strong acid catalyzed intramolecular cyclization reaction to provide initially aldehyde products which are further converted to their corresponding unsaturated esters via a Wittig reaction in order to determine the e.e.‐values.
ChemInform Abstract: Hypoiodite‐Mediated Metal‐Free Catalytic Aziridination of Alkenes.
Authors: Yoshimura Akira , Middleton Kyle R. , Zhu Chenjie , Nemykin Victor N. , Zhdankin Viktor V. 
Published: January 2013

AbstractFor the first time the title reaction is presented by using the compound (II) as the nitrenium precursor and common inexpensive reagents.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Cyclization of 3‐Bromoallyl Alcohols Leading to Furan‐2‐(5H)‐ones.
Authors: Lee Hye Kyung , Cho Chan Sik 
Published: January 2013

AbstractThe title reaction provides a promising route for the synthesis of valuable heterocycles from readily available starting ketones.
ChemInform Abstract: Microwave‐Assisted Claisen Rearrangement of Naphthyl 2‐Propynyl Ethers: Synthesis of Naphthofurans.
Authors: Lingam V. S. Prasada Rao , Dahale Dnyaneshwar H. , Mukkanti Kagga , Gopalan Balasubramanian , Thomas Abraham 
Published: January 2013

AbstractThe two‐step synthesis of the title skeletons involves etherification of naphthols under Mitsunobu conditions, Claisen rearrangement and concomitant cyclization.
ChemInform Abstract: Pd‐Mediated Functionalization of Polysubstituted Pyrroles: Their Evaluation as Potential Inhibitors of PDE4.
Authors: Pal Manojit , et al. et al. 
Published: January 2013

AbstractNovel polysubstituted pyrroles are synthesized via one‐pot multicomponent condensation followed by usual Pd‐catalyzed C—C bond forming reactions.
ChemInform Abstract: Palladium‐Catalyzed Reaction of Arylamine and Diarylacetylene: Solvent‐Controlled Construction of 2,3‐Diarylindoles and Pentaarylpyrroles.
Authors: Chen Xiaopeng , Li Xihui , Wang Ningning , Jin Jisong , Lu Ping , Wang Yanguang 
Published: January 2013

AbstractA phosphane‐free, highly atom‐efficient, and mild basic method for the synthesis of the title compounds is developed.
ChemInform Abstract: Pentanidium‐Catalyzed Enantioselective α‐Hydroxylation of Oxindoles Using Molecular Oxygen.
Authors: Yang Yuanyong , Moinodeen Farhana , Chin Willy , Ma Ting , Jiang Zhiyong , Tan Choon‐Hong 
Published: January 2013

AbstractHydroperoxide oxindoles are formed as by‐products.
ChemInform Abstract: Stereoselective Synthesis of 2,3‐Disubstituted Indoline Diastereoisomers by Chemoenzymatic Processes.
Authors: Lopez‐Iglesias Maria , Busto Eduardo , Gotor Vicente , Gotor‐Fernandez Vicente 
Published: January 2013

AbstractThe enzyme efficiently promotes optical resolution of a number of 2,3‐cis‐substituted indolines.
ChemInform Abstract: Discovery of a Potent, Orally Bioavailable and Highly Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitor, N‐(1‐(Piperidin‐4‐yl)indolin‐5‐yl)thiophene‐2‐carboximidamide as a Pre‐Clinical Development Candidate for the Treatment of Migraine.
Authors: Annedi Subhash C. , et al. et al. 
Published: January 2013

AbstractCompound (Ia) is a potent and highly selective inhibitor of nNOS that has favorable physicochemical properties with exceptional oral bioavailability.
ChemInform Abstract: Chemoenzymatic Synthesis and Evaluation of 3‐Azabicyclo[3.2.0]heptane Derivatives as Dopaminergic Ligands.
Authors: Reinart‐Okugbeni Reet , Ausmees Kerti , Kriis Kadri , Werner Franz , Rinken Ago , Kanger Tonis 
Published: January 2013

AbstractNew 3‐azabicycloheptane derivatives (IV) are synthesized via a multicomponent cascade reaction and resolved by kinetic enzymatic resolution with immobilized lipase B.
ChemInform Abstract: Solvent‐Free Synthesis of 3,5‐Di‐tert‐butylpyrazole and 3,5‐Di‐substituted‐butylpyrazol‐1‐ylethanol.
Authors: van Wyk Juanita L. , Omondi Bernard , Appavoo Divambal , Guzei Ilia A. , Darkwa James 
Published: January 2013

AbstractThe title compounds (III) and (IV) are readily obtained by solvent‐free condensation of the appropriate diketone and hydrazine derivatives.
ChemInform Abstract: Green Synthesis and Antiinfective Activities of Fluorinated Pyrazoline Derivatives.
Authors: Shelke Sharad N. , Mhaske Ganesh R. , Bonifacio Vasco D. B. , Gawande Manoj B. 
Published: January 2013

AbstractA small panel of novel pyrazoles (II) is synthesized from the corresponding chalcones using ultrasound irradiation.
ChemInform Abstract: A General and Regioselective Synthesis of 5‐Trifluoromethyl‐pyrazoles.
Authors: Foster Robert S. , Jakobi Harald , Harrity Joseph P. A. 
Published: January 2013

AbstractSydnones (III) are prepared by two approaches as precursors for the cycloaddition reaction with terminal or internal alkynes to give the pyrazoles.
ChemInform Abstract: Preparation of Novel Di‐Isoxazolines Using Bis(nitrile oxide) 1,3‐Dipolar Cycloaddition Methodology.
Authors: Bigdeli Mohammad Ali , Halimehjani Azim Ziyaei , Mohammadipour Mohammad , Sagharichi Parishad 
Published: January 2013

AbstractDi‐isoxazolines, cf.
ChemInform Abstract: Urea/Thiourea Catalyzed, Solvent‐Free Synthesis of 5‐Arylidenethiazolidine‐2,4‐diones and 5‐Arylidene‐2‐thioxothiazolidin‐4‐ones.
Authors: Shah Sakshi , Singh Baldev 
Published: January 2013

AbstractSimilar results are obtained with thiourea as catalyst.
ChemInform Abstract: The Discovery of New Potent Non‐peptide Angiotensin II AT1 Receptor Blockers: A Concise Synthesis, Molecular Docking Studies and Biological Evaluation of N‐Substituted 5‐Butylimidazole Derivatives.
Authors: Agelis George , et al. et al. 
Published: January 2013

AbstractCompound (VII) is a very potent ANG II AT1 antagonist.
ChemInform Abstract: Pd(II)‐Mediated Cyclization of o‐Allylbenzaldehydes in Water: A Novel Synthesis of Isocoumarins.
Authors: Chen Po‐Yuan , Huang Keng‐Shiang , Tsai Chin‐Chuan , Wang Tzu‐Pin , Wang Eng‐Chi 
Published: January 2013

AbstractUnder optimized conditions using a copper salt in addition to the palladium catalyst and water as both reagent and solvent, high yields of the isocoumarins are obtained within an hour.
ChemInform Abstract: Mesoporous and Hexagonally Ordered CuAl‐SBA‐15‐Catalyzed Tandem C—C and C—O Bond Formation Between Phenols and Allylic Alcohols.
Authors: Varghese Shaji , Anand Chokkalinkam , Dhawale Dattatray , Mano Ajayan , Balasubramanian Veerappan V. , Raj George Allen Gnana , Nagarajan Samuthira , Wahab Mohammad A. , Vinu Ajayan 
Published: January 2013

AbstractA novel reusable mesoporous catalyst incorporating Cu and Al with a hexagonally ordered structure is prepared and applied to the annulation of phenols with allylic alcohols to yield dihydrobenzopyrans.
ChemInform Abstract: Methanesulfonic Acid‐Catalyzed One‐Pot Synthesis of 12‐Aryl‐ or 12‐Alkyl‐8,9,10,12‐tetrahydrobenzo[a]xanthen‐11‐one Derivatives
Authors: Liu Yu‐Heng , Li Lei 
Published: January 2013

Abstractvia condensation of various aldehydes, 2‐naphthol, and cyclic 1,3‐dicarbonyl compounds under mild and solvent‐free conditions
ChemInform Abstract: [4 + 2] Annulation of Vinyl Ketones Initiated by a Phosphine‐Catalyzed Aza‐Rauhut—Currier Reaction: A Practical Access to Densely Functionalized Tetrahydropyridines.
Authors: Shi Zugui , Tong Qinjie , Leong Wendy Wen Yi , Zhong Guofu 
Published: January 2013

AbstractIn the presence of catalytic amounts of PPh3 and p‐methoxyphenol, N‐sulfonyl‐1‐aza‐1,3‐dienes undergo the title reaction with vinyl ketones to give the isolated pyridine derivatives exclusively as trans‐isomers.
ChemInform Abstract: Multi‐Component, 1,3‐Dipolar Cycloaddition Reactions for the Chemo‐, Regio‐ and Stereoselective Synthesis of Novel Hybrid Spiroheterocycles in Ionic Liquid.
Authors: Rajesh Stephen Michael , Bala Balasubramainan Devi , Perumal Subbu 
Published: January 2013

AbstractThree‐ and four‐component reactions of bisarylidene tetrahydropyridones are described provide a selective access to spiroheterocycles (IV) and (VII) as single diastereomers.
ChemInform Abstract: A Divergent Approach to 3‐Piperidinols: A Concise Syntheses of (+)‐Swainsonine and Access to the 1‐Substituted Quinolizidine Skeleton.
Authors: Archibald Glenn , Lin Chih‐Pei , Boyd Peter , Barker David , Caprio Vittorio 
Published: January 2013

AbstractTreatment of the nitrone (I) with Grignard reagents or organolithium compounds results in efficient and stereoselective formation of trans‐2‐substituted 3‐piperidinols such as (IV).
ChemInform Abstract: Design, Synthesis, and Structure—Activity Relationships of a Series of 2‐Ar‐8‐methyl‐5‐alkylaminoquinolines as Novel CRF1 Receptor Antagonists.
Authors: Takeda Kunitoshi , Terauchi Taro , Hashizume Minako , Shin Kogyoku , Ino Mitsuhiro , Shibata Hisashi , Yonaga Masahiro 
Published: January 2013

AbstractNovel compounds (VI) are identified as orally active corticotropin‐releasing factor 1 (CRF1) receptor antagonists.
ChemInform Abstract: Synthesis of Quinoline Dicarboxylic Esters as Biocompatible Fluorescent Tags.
Authors: Laras Younes , Hugues Vincent , Chandrasekaran Yogesh , Blanchard‐Desce Mireille , Acher Francine C. , Pietrancosta Nicolas 
Published: January 2013

AbstractTreatment of anilines with the keto ester (II) allows an improved access to quinoline dicarboxylic esters.
ChemInform Abstract: A General Access to 1,1‐Cyclopropane Aminoketones and Their Conversion into 2‐Benzoyl Quinolines.
Authors: Mao Zhenjun , Qu Haijun , Zhao Yanyan , Lin Xufeng 
Published: January 2013

AbstractA novel, direct synthesis of 1,1‐cyclopropane aminoketones via base‐mediated tandem reaction of α‐amino ketones with vinyl sulfonium salts is developed.
ChemInform Abstract: Unexpected Formation of O‐Acylhydroxamate from the Oxidation of a Dihydroisoquinoline Imine.
Authors: Saleh Hassen Ben , Kammoun Majed , Hamdi Besma , Damak Mohamed 
Published: January 2013

AbstractThe MCPBA oxidation of imine (I) is studied and a possible mechanism leading to the unexpected O‐acylhydroxamate (II) is discussed.
ChemInform Abstract: Catalytic Synthesis of Fused 1,4‐Dihydropyridines and 1,4‐Dihydropyridine Derivatives Using Preyssler Heteropolyacids Catalyst.
Authors: Gharib Ali , Jahangir Manouchehr , Roshani Mina , Scheeren J. W. 
Published: January 2013

AbstractHeteropolyacid catalyzed Hantzsch dihydropyridine syntheses are described.
ChemInform Abstract: Synthesis of Isoxazolopyrroloisoquinolines by Intramolecular Cyclizations of 5‐(2‐Arylethyl)‐6‐hydroxytetrahydro‐4H‐pyrrolo[3,4‐d]isoxazol‐4‐ones.
Authors: Stepakov Alexander V. , Ledovskaya Maria S. , Boitsov Vitaly M. , Molchanov Alexander P. , Kostikov Rafael R. , Gurzhiy Vladislav V. , Starova Galina L. 
Published: January 2013

AbstractThe BF3‐mediated intramolecular cyclization of the title substrates (I) provides trans‐isomers (II), which represent structural fragments of Erythrina alkaloids, as sole or major products.
ChemInform Abstract: Metal‐Cocatalyzed Tandem Alkynylative Cyclization Reaction of in situ Formed N‐Iminoisoquinolinium Ylides with Bromoalkynes via C—H Bond Activation.
Authors: Huang Ping , Yang Qin , Chen Zhiyuan , Ding Qiuping , Xu Jingshi , Peng Yiyuan 
Published: January 2013

AbstractIt provides a new and efficient method to prepare various pyrazoloisoquinolines of biological interest.
ChemInform Abstract: Unexpected Configuration in Stereoselectively Synthesis of Some Novel (1Z)‐1‐(Morpholin‐1‐yl)‐N2‐arylamidrazones.
Authors: Bhat Mashooq A. , Al‐Rashood Khalid A. , Abdel‐Aziz Hatem A. 
Published: January 2013

AbstractReaction of hydrazonoyl chlorides (I) with piperidine affords the expected amidrazones (III), whilst similar reaction with morpholine proceeds with retention of the (Z)‐configuration furnishing (1Z)‐morpholinylamidrazones (V).
ChemInform Abstract: Synthesis of Some 1‐(Flavon‐7‐yl)‐4,5‐dihydro‐1,2,4‐triazin‐6(1H)‐ones and Related Congeners.
Authors: Abu‐Aisheh Marwa N. , Mustafa Mohammad S. , Mubarak Mohammad S. , El‐Abadelah Mustafa M. , Voelter Wolfgang 
Published: January 2013

AbstractA variety of new flavonyltriazinones is synthesized via direct condensation of α‐amino acid esters with nitrile imines, generated in situ from hydrazonoyl chlorides (III).
ChemInform Abstract: Synthesis of Tricyclic Systems Containing a Fused Thieno[3,4‐d]pyrimidine Nucleus.
Authors: El‐Telbany Farag A. , El Hakeem Maha Abd , Khalil Omneya M. , Mikhail Demiana S. 
Published: January 2013

AbstractA variety of new title compounds are obtained starting from the useful synthon 4‐cyano‐3‐ethoxymethyleneamino‐5‐phenylamino‐2‐thiophenecarboxylate (I).
ChemInform Abstract: Gold‐Catalyzed Cyclizations of (o‐Alkynyl)phenoxyacrylates with External Nucleophiles: Regio‐ and Stereoselective Synthesis of Functionalized Benzo[b]oxepines.
Authors: Liu Jun , Liu Yuanhong 
Published: January 2013

AbstractAlcohols and vinyl ether (XVI) generate the same benzoxepine systems.
ChemInform Abstract: Preparation and Diels—Alder/Cross‐Coupling Reactions of New 2‐Boron‐Substituted 1,3‐Dienes.
Authors: Wang Liqiong , Welker Mark E. 
Published: January 2013

AbstractSome new 2‐boron‐substituted dienes are prepared following the sequence A)‐C) and treatment with a polyol as is demonstrated for (III).
ChemInform Abstract: Enantioselective Carbonyl Propargylation by Iridium‐Catalyzed Transfer Hydrogenative Coupling of Alcohols and Propargyl Chlorides.
Authors: Woo Sang Kook , Geary Laina M. , Krische Michael J. 
Published: January 2013

AbstractThe desired compounds are prepared from silyl‐substituted propargyl chlorides and benzyl alcohols or aromatic aldehydes.
ChemInform Abstract: Pd‐Catalyzed Modifiable Silanol‐Directed Aromatic C—H Oxygenation.
Authors: Huang Chunhui , Ghavtadze Nugzar , Godoi Benhur , Gevorgyan Vladimir 
Published: January 2013

AbstractA variety of oxasilacycles are prepared from diisopropyl(benzyl)silanol derivatives by the title reaction.
ChemInform Abstract: Cytotoxic Terpenes from the Stems of Dipterocarpus obtusifolius Collected in Cambodia.
Authors: Khiev Piseth , Kwon Ok‐Kyoung , Song Hyuk‐Hwan , Oh Sei‐Ryang , Ahn Kyung‐Seop , Lee Hyeong‐Kyu , Chin Young‐Won 
Published: January 2013

AbstractFive new triterpenes are isolated from the stems of dipterocarpus obtusifolius along with 13 known compounds.
ChemInform Abstract: Physical Chemistry of Ionic Liquids: Inorganic and Organic as Well as Protic and Aprotic
Authors: Angell C. A. , Xu W. , Yoshizawa‐Fujita M. , Hayashi A. , Belieres J.‐P. , Lucas P. , Videa M. , Zhao Z.‐F. , Ueno K. , Ansari Y. , et al. et al. 
Published: January 2013

AbstractReview: 83 refs.
Separation of Nadolol Stereoisomers by Chiral Liquid Chromatography at Analytical and Preparative Scales
Authors: Ribeiro António E. , Rodrigues Alírio E. , Pais Luís S. 
Published: January 2013

ABSTRACTThe separation of the four nadolol stereoisomers on Chiralpak® AD by chiral liquid chromatography was carried out at both analytical and preparative scales. A screening of possible mobile‐phase compositions was performed using different alcohol–hydrocarbon mixtures. The results obtained confirm the use of 20:80:0.3 ethanol‐hexane‐diethylamine reported by McCarthy (1994) but introduce other possibilities for the complete resolution of the four nadolol stereoisomers at analytical scale, namely, the mixtures 30–40:70–60:0.3 ethanol‐heptane‐diethylamine. Additionally, this work describes how retention and resolution depend on the ethanol content in hexane and heptane mixtures. The separation of nadolol stereoisomers is also carried out at preparative scale and different alcohol–hydrocarbon compositions are proposed, depending on the target component to be obtained. Particularly, this work presents the experimental separation of the more retained nadolol stereoisomer (RSR‐nadolol) by simulated moving bed (SMB) chromatography using an 80:20:0.3 ethanol‐heptane‐diethylamine mobile phase. For a 2 g/l feed concentration, RSR‐nadolol is 100% recovered at the extract outlet stream, 100% pure, and with a system productivity of 0.65 gRSR‐nadolol/(lbed.h) and a solvent consumption of 9.6 lsolvent/gRSR‐nadolol. Chirality 25:197–205, 2013. © 2013 Wiley Periodicals, Inc.
Relevant Reducing Agents in Remediation Fe0/H2O Systems
Authors: Noubactep Chicgoua 
Published: January 2013

AbstractMetallic iron (Fe0) is often reported as a reducing agent for environmental remediation. There is still controversy as to whether Fe0 plays any significant direct role in the process of contaminant reductive transformation. The view that Fe0 is mostly a generator of reducing agents (e.g. H, H2 and FeII) and Fe oxyhydroxides has been either severely refuted or just tolerated. The tolerance is based on the simplification that, without Fe0, no secondary reducing agents could be available. Accordingly, Fe0 serves as the original source of electron donors (including H, H2 and FeII). The objective of this communication is to refute the named simplification and establish that quantitative reduction results from secondary reducing agents. For this purpose, reports on aqueous contaminant removal by Al0, Fe0 and Zn0 are comparatively discussed. Results indicated that reduction may be quantitative in aqueous systems containing Fe0 and Zn0 while no significant reduction is observed in Al0/H2O systems. Given that Al0 is a stronger reducing agent than Fe0 and Zn0, it is concluded that contaminant reduction in Fe0/H2O systems results from synergic interactions between H/H2 and FeII within porous Fe oxyhydroxides. This conclusion corroborates the operating mode of Fe0 bimetallics as H/H2 producing systems for indirect contaminant reduction.