bluuebunny/crossref_metadata_2025_split huggingface dataset:
PROFIL PEMBELAJARAN KEANEKARAGAMAN HAYATI DI SMAN 3 BANDUNG
Authors: Gusti Utari Akhir , Hidayat Topik , Sriyati Siti 
Published: July 2024

Penelitian ini bertujuan untuk memberikan gambaran pembelajaran keanekaragaman hayati di SMAN 3 Bandung. Metode penelitian yang digunakan yaitu kualitatif dengan desain fenomenologi. Sumber data berasal dari wawancara, lembar observasi, dan pengamatan langsung. Sekolah ini tidak hanya memanfaatkan fasilitas laboratorium dan perpustakaan untuk menyediakan pengetahuan teoritis, tetapi juga memaksimalkan penggunaan taman sekolah sebagai ruang pembelajaran luar kelas. Dengan pembelajaran ini, siswa dapat mengamati, mendokumentasikan, dan mengapresiasi keanekaragaman hayati secara langsung. Penerapan Kurikulum Merdeka dan konsep Sekolah Adiwiyata/green school memberikan dasar yang kokoh untuk pendekatan pembelajaran yang berkelanjutan dan inklusif. Hasil penelitian menunjukkan bahwa pembelajaran ini menciptakan siswa yang tidak hanya memiliki pemahaman konseptual yang mendalam, tetapi juga memiliki keterampilan praktis dan kesadaran lingkungan yang tinggi. SMAN 3 Bandung berhasil mengintegrasikan pembelajaran di dalam dan luar kelas, menciptakan lingkungan belajar yang dinamis dan mendukung bagi siswa untuk memahami, menghargai, dan berpartisipasi dalam konservasi keanekaragaman hayati. Dalam memaksimalkan proses pembelajaran perlu dilakukan penilaian terhadap keterampilan dan sikap peserta didik.
The Effectiveness of a Therapeutic Program Based on Musical Songs in Alleviating the Phenomenon of Social Shyness Among Kindergarten Children
Authors: Nasir Tamara Mahmoud Aqla 
Published: July 2024

This study aimed to measure the effectiveness of a therapeutic program based on musical songs in alleviating the phenomenon of social shyness among kindergarten in the schools in the city of Irbid, numbering (340) children. The Rovan Model School and Kindergarten, numbering (70) children, was chosen intentionally from the kindergartens of the study community due to its proximity to the researcher’s residence. Then (25) children who suffer from social shyness, aged (5-6) years, were selected. By useing The study used the experimental method with a quasi-experimental design, for one group (one division). The study shows that: there are statistically significant differences (α≤0.05) between the pre- and post-applications in the average degree of performance of the study sample children on the social shyness scale.and when reviewing the arithmetic averages it became clear that these differences were in favor of the post-measurement; The arithmetic averages for the postscale are higher than those for the delayed measurement, and this may be due to the children not continuing to communicate and integrate with the musical songs after completing the application of the therapeutic program for a short period of time, which affected the children by other extraneous factors such as motor sports activities, internal trips, or family visits. , or official holidays.
Sosialisasi dan Pendampingan Pengurusan Nomor Induk Berusaha untuk Pelaku UMKM Jual Beli Kambing AIM
Authors: Hakim Achmad Ali Yudin , Ramadhan Rizky Oktavian , Wahid M Nur , Qurratu’aini Nafia Ilhama 
Published: July 2024

NIB merupakan nomor identitas berusaha yang digunakan oleh pelaku usaha untuk mendapatkan izin usaha dan izin komersial dan operasional. NIB atau Nomor Induk Berusaha sebagai legalitas sebuah usaha merupakan sebuah kewajiban bagi pelaku usaha dalam menjalankan usahanya. Metode yang digunakan pada pendampingan pengurusan UMKM ini ialah dengan melakukan sebuah observasi dan juga pendekatan ke pihak pelaku UMKM jual beli kambing AIM yang berada di Desa Balonggabus Kecamatan Candi Kabupaten Sidoarjo. Artikel ini ditulis menggunakan metode kualitatif dan deskriptif dengan melakukan tanya jawab kepada pemilik UMKM jual beli kambing AIM. Sosialisasi dan pendampingan pembuatan NIB yang dilakukan di Desa Balonggabus Kecamatan Candi Kabupaten Sidoarjo pada bulan April 2024 mendapatkan respon yang positif dari bapak Kojim sebagai pelaku usaha mikro Jual Beli Kambing AIM. Pendampingan dilakukan nya pembuatan Nomor Induk Berusaha NIB yaitu kurangnya pengetahuan yang dimiliki oleh para pelaku usaha, terutama yang berasal dari kalangan tua. NIB sangatlah penting bagi suatu usaha, tetapi masih banyak para pelaku usaha yang kurang faham tentang adanya NIB dan juga masih belum mengetahui cara membuat NIB tersebut.
Kesejahteraan Psikologis Pelajar Sekolah Berasrama: Analisis Hubungan Interpersonal dan Efikasi Diri
Authors: Dewi Utami  , Dadan Mardani  
Published: July 2024

This study aims to analyze the psychological well-being of boarding school students with a focus on interpersonal relationships and self-efficacy. This research employs a quantitative approach with a correlational survey design, involving 111 boarding school students in Indonesia. Data collection instrument is questionnaire to measure students’ psychological well-being referencing to two dimensions of self acceptance and positive relation with other. The analysis results indicate that interpersonal relationships and self-efficacy significantly influence students' psychological well-being. The average score for interpersonal relationships was 3.47, for loneliness and social support was 2.63, and for self-confidence was 3.29. These findings highlight the importance of strengthening social relationships and beliefs in students’ ability to complete a task in order to enhance psychological well-being. Recommendations are provided to develop social support programs and self-efficacy training skills in boarding schools.
ASSOCIATION BETWEEN IRON STATUS AND GESTATIONAL DIABETES MELLITUS
Authors: Naureen Tallat , Ahmed Umbreen , Riaz Bushra , Ali Ujala , Sharafat Javaria , Shabbir Ehsan 
Published: July 2024

Background: Early identification of risk factors for gestational diabetes may result in its prevention and better management. In this study, we aimed to compare serum iron, total iron binding capacity and transferring saturation in pregnant women with and without gestational diabetes. Methods: A comparative cross sectional analytical study was conducted at Army Medical College and Centre for Research in Experimental and Analytical Medicine (CREAM) in association with Pak Emirates Military Hospital. Thirty healthy pregnant women and thirty patients of gestational diabetes mellitus matched for age, gestational age and body mass index (BMI) were recruited for the study. The diagnosis of gestational diabetes was made on the basis of abnormal glucose tolerance test at twenty four weeks of gestation. Serum iron and total iron binding capacity of all subjects were measured using colorimetric assay and transferrin saturation was calculated. Analysis of data was carried using SPSS-22. Mean values were calculated for all variables and compared by two sample t-test. Pearson correlation was determined to find association between different quantitative variables in two groups and p?0.05 was considered significant. Results: Serum iron was significantly higher (p=0.007), TIBC significantly lower (p=0.004) and transferrin saturation significantly higher (p<0.001) in gestational diabetes group as compared to control group. Conclusion: Markers of iron status including serum iron and transferrin saturation were higher in patients of gestational diabetes and may pose a risk of developing gestational diabetes mellitus.
Pak J Physiol 2022;18(2):47–50
TYPES OF ITEM WRITING FLAWS IN MULTIPLE CHOICE QUESTIONS IN MEDICAL EDUCATION AND THEIR EFFECT ON PASSING RATE OF STUDENTS
Authors: Awan Sarmud Latif , Manzoor Shagufta , Gillani Irum , Kayani Ziyad Afzal , Farooq Humza , Khurshid Sahar 
Published: July 2024

Background: The most popular written exam in health professions education is the multiple-choice style question (MCQ). This study sought to understand the effects of multiple-choice writing errors on students' academic performance in medical education. Methods: This descriptive study was done from December 2017 to June 2019 in Azad Jammu Kashmir (AJK) Medical College, Muzaffarabad. Ten block examinations were included. The item review committee reviewed all MCQs for flaws. Two tests from each class of MBBS were taken. The original tests containing all items were labeled as flawed tests and the result of each flawed test was evaluated. The students were graded into high, moderate and low achievement groups with scores of more than 79.9, between 50–79.9 and less than 50 percent respectively. Flawed items were then removed from the tests by the review committee and the scores of each test (standard test) were determined and compared with flawed tests and its effects were assessed in three achieving groups of students. Optical mark reading (OMR) classic-4 software was used for post-exam analysis and data were analyzed by using SPSS-25. Results: The passing rate ranged from 68.18% to 90.82% in flawed and 75.54% to 93.69% in standard tests. Most standard tests (7) had higher passing rates than flawed tests. Conclusion: Tests containing in-house developed MCQs have frequent item writing flaws and their inclusion in assessment did affect the passing rates of students but were not statistically significant.
Pak J Physiol 2023;19(4):49–52
EFFECT OF WHITE SUGAR, BROWN SUGAR AND JAGGERY POWDER SYRUP ON BIOCHEMICAL AND HISTOPATHOLOGICAL MARKERS OF SPRAGUE-DAWLEY RATS
Authors: Lodhi Hifza Noor , Chaudry Sana Rasheed , Nasreen Shagufta , Siddiqui Amer Hassan , Yousaf Rana Muhammad , Chiragh Sadia , Saeed Muniza 
Published: July 2024

Hypertension accounts for 10% of the total annual health budget in developed countries.1 By 2025, the number of people living with hypertension is expected to reach 1.56 billion people.2Dietary factors that increase blood pressure (BP) are of interest to public health authorities.3,4Twenty adult male Sprague-Dawley rats were taken. All groups received standard chow ad libitum. Controls (A), received plain drinking water, and the Sucrose treatment rats received 10% sucrose solution prepared daily for 12 weeks. Non-invasive blood pressure was recorded using computer based data recording system power lab model: M-ML 856, Australia with rat tail cuff attachment.Blood samples were collected. Serum aliquots were frozen at ?80°C for: ALT, AST, TG, total cholesterol (TC), and high-density lipoprotein (HDL) were determined using commercial enzymatic methods (CELM diagnosis, São Paulo, Brazil). The concentration of VLDL and low-density lipoprotein was measured.
ANOVA and Post-Hoc Tukey tests were applied to determine statistical difference among the study groups.
The results showed variable effects on biochemical and histopathological findings in rat liver, kidney and pancreas. The pancreas and kidneys of the rats showed adverse inflammatory histopathological changes maximally in rats taking jaggery syrup (Shakkar) flowed by white sugar and minimal in Shakkar. The adverse effects on liver cells were maximally seen on rats given brown sugar.
This study enabled us to better understand the biochemical and histopathological effects of various types of sugars available in Pakistani market in order to create awareness regarding their effects on health.
Beton wałowany z wykorzystaniem kruszywa z recyklingu do wykonywania nawierzchni dróg lokalnych
Authors: Graczyk Mirosław , Bebłacz Danuta 
Published: July 2024

Beton wałowany RCC jest specjalną odmianą mieszanki betonowej o optymalnej wilgotności, zbliżonej do wilgotności gruntu. Układany jest standardowym rozściełaczem asfaltowym i zagęszczany przy użyciu walców drogowych. Technologia betonu wałowanego ze względu na swoje zalety: jak szybkość realizacji i niskie koszty budowy, jest dobrym rozwiązaniem w budowie dróg lokalnych. Beton wałowany jest doskonałą i nowoczesną alternatywą dla innych mieszanek, gdzie z powodzeniem można zastosować materiały z recyklingu, zatem warto zastanowić się nad szerszym jej wykorzystaniem w budowie dróg Polsce. W artykule zostaną przedstawione wymagania dla materiałów stosowanych do produkcji betonu wałowanego, sposób wykonania nawierzchni z betonu wałowanego. Poruszone zostanie również zagadnienie wykorzystania istniejącej nawierzchni do produkcji betonu wałowanego np. gruz betonowy uzyskany z nawierzchni z płyt drogowych, destrukt asfaltowy.
Skuteczność specjalistycznego preparatu chemicznego w odświeżaniu granulatu asfaltowego
Authors: Jurczak Robert , Mieczkowski Paweł , Merska Oliwia , Ratajczak Maria 
Published: July 2024

Materiały stosowane w budownictwie powinny funkcjonować w obiegu zamkniętym, co oznacza ich ponowne wykorzystanie w momencie utraty właściwości w pierwotnym wyrobie budowlanym. Do tego typu materiałów należy zaliczyć mieszanki mineralno-asfaltowe, które w postaci destruktu asfaltowego pozyskiwane są z remontowanych lub przebudowywanych dróg. Ich funkcjonalność w dużym stopniu zależy od właściwości lepiszcza asfaltowego, które w wyniku procesów starzeniowych utraciło swoje właściwości lepkosprężyste. Poprawę tych właściwości można uzyskać poprzez zastosowanie specjalistycznych preparatów chemicznych zwanych rejuvenatorami. W artykule przedstawiono wyniki badań, które podzielono na dwa etapy. W pierwszym etapie badania wykonywano dla lepiszcza asfaltowego. Wykorzystano asfalt drogowy 50/70 przed i po starzeniu (RTFOT + PAV) oraz postarzone lepiszcze z dodatkiem rejuvenartora. Obok badań podstawowych (penetracji, temperatury mięknienia, zespolonego modułu ścinania i kąta przesunięcia fazowego) oznaczono skład grupowy asfaltów oraz wykonano analizy widmowe. W drugim etapie badania wykonano dla betonu asfaltowego AC 16 W 50/70, pozyskanego z WMB. Oznaczono podstawowe parametry mieszanki referencyjnej, po starzeniu technologicznym oraz eksploatacyjnym oraz z udziałem odświeżacza. W zakresie oznaczeń była gęstość, gęstość objętościowa, odporność na działanie wody, moduł sztywności, trwałość zmęczeniowa oraz parametry niskotemperaturowe mieszanki (TSRST). Przeprowadzone badania granulatu asfaltowego z udziałem esteru fosforowego alkoholu oleilowego, etoksylowanego świadczą, że substancja ta wpływa pozytywnie na zmiany właściwości zestarzonych lepiszczy asfaltowych, co pozwala z powodzeniem stosować ją w technologii drogowej
Recykling na zimno ze spienionym asfaltem, wiedza zdobyta z toru testowego w Niemczech
Authors: Kalantari Mehdi 
Published: July 2024

W ostatnich latach w UE znacznie wzrosło zapotrzebowanie na bardziej zrównoważoną infrastrukturę transportową. W Niemczech celem politycznym jest osiągnięcie neutralności klimatycznej do 2035 roku. Wśród różnych rozwiązań, recykling to ważny aspekt na drodze do osiągnięcia gospodarki o obiegu zamkniętym w odniesieniu do nawierzchni, jako jednej z głównych części infrastruktury transportowej. Recykling na zimno to technika, która wymaga mniej energii i może potencjalnie wykorzystywać większe ilości materiałów pochodzących z recyklingu. Uzyskany materiał może nie mieć takich samych właściwości jak konwencjonalna mieszanka asfaltowa na gorąco, ale dzięki zoptymalizowanej mieszance i projektowi strukturalnemu możliwe jest wykonanie nawierzchni o takiej samej lub nawet wyższej trwałości niż konwencjonalne rodzaje nawierzchni, ale o większym potencjale w zakresie zrównoważonego rozwoju. W 2018 r. w Federalnym Instytucie Badawczym Drogownictwa (BASt) we współpracy z Wirtgen GmbH zdefiniowano projekt badawczy na temat recyklingu na zimno z asfaltem spienionym. Głównym celem projektu było zebranie informacji i doświadczeń na temat zachowania zimnego materiału pochodzącego z recyklingu ze stosunkowo niewielką ilością bitumu i cementu, znanego na całym świecie jako Bitumen Stabilised Materials (BSM). W tym celu zbudowano 100-metrowy odcinek testowy na obszarze demonstracyjnym, badawczym i referencyjnym BASt (duraBASt) z dwoma różnymi typami konstrukcji (referencyjnym i z recyklingu na zimno). Oba odcinki zostały obciążone za pomocą mobilnego symulatora obciążenia (MLS30). W niniejszym artykule przedstawiono niektóre wyniki i ustalenia z nieniszczącego monitorowania (pomiary FWD i koleinowania) i badań wydobytych rdzeni. Program dowiódł, że możliwe jest zaprojektowanie i wykonanie nawierzchni z BSM o porównywalnych parametrach jak nawierzchnie konwencjonalne w Niemczech.
Investigating the regulatory role of HvANT2 in anthocyanin biosynthesis through protein–motif interaction in Qingke
Authors: Wang Yan , Chen Lin , Yao Youhua , Chen Lupeng , Cui Yongmei , An Likun , Li Xin , Bai Yixiong , Yao Xiaohua , Wu Kunlun 
Published: July 2024

Background
Currently, there are no reports on the HvbHLH gene family in the recent barley genome (Morex_V3). Furthermore, the structural genes related to anthocyanin synthesis that interact with HvANT2 have yet to be fully identified.

Methods
In this study, a bioinformatics approach was used to systematically analyze the HvbHLH gene family. The expression of this gene family was analyzed through RNA sequencing (RNA-seq), and the gene with the most significant expression level, HvANT2, was analyzed using quantitative reverse transcription polymerase chain reaction (qRT-PCR) in different tissues of two differently colored varieties. Finally, structural genes related to anthocyanin synthesis and their interactions with HvANT2 were verified using a yeast one-hybrid (Y1H) assay.

Results
The study identified 161 bHLH genes, designated as HvbHLH1 to HvbHLH161, from the most recent barley genome available. Evolutionary tree analysis categorized barley bHLH TFs into 21 subfamilies, demonstrating a pronounced similarity to rice and maize. Through RNA-Seq analysis of purple and white grain Qingke, we discovered a significant transcription factor (TF), HvANT2 (HvbHLH78), associated with anthocyanin biosynthesis. Subsequently, HvANT2 protein-motifs interaction assays revealed 41 interacting motifs, three of which were validated through Y1H experiments. These validated motifs were found in the promoter regions of key structural genes (CHI, F3’H, and GT) integral to the anthocyanin synthesis pathway. These findings provide substantial evidence for the pivotal role of HvANT2 TF in anthocyanin biosynthesis.
Construction and validation of a prognostic model for gastric cancer patients with tumor deposits
Authors: Xu Ran , Zhang Yisheng , Wang Zhengguang , Chen Ke , Zhao Jun 
Published: July 2024

Background
Tumor deposits (TD) was a significant risk factor impacting the prognosis of patients diagnosed with gastric cancer (GC), yet it was not currently incorporated into TNM staging systems. The objective of this research was to develop a predictive model for assessing the prognosis of patients with TD-positive GC.

Methods
Retrospective analysis was performed on the data of 4,972 patients treated for GC with D2 radical gastrectomy at Wannan Medical College’s Yijishan Hospital between January 2012 and December 2021. The patients were categorized based on the number of TD (L1: 1, L2: 2–3, L3: ≥4) and the anatomical location of TD (Q1: single area, Q2: multiple areas). In a 3:1 ratio, patients were randomly assigned to one of two groups: training or validation.

Results
The study included a total of 575 patients who were divided into the training group (n = 432) and validation group (n = 143). Survival analysis showed that the number and anatomical location of TD had a significant impact on the prognosis of patients with TD-positive GC. Univariate analysis of the training group data revealed that tumor size, T-stage, N-stage, histological grade, number and distribution of TD, neural invasion, and postoperative chemotherapy were associated with prognosis. Multivariate Cox regression analysis identified poor histological grade, T4 stage, N3 stage, number of TD, neural invasion, and postoperative chemotherapy as independent prognostic factors for GC patients with TD. A nomogram was developed using these variables, demonstrating well predictive ability for 1, 3, and 5-year overall survival (OS) in the validation set. The DCA curve shows that the constructed model shows a large positive net gain compared to the eighth edition Tumour, Node, Metastasis (TNM) staging system.

Conclusion
The prognostic model developed for patients with TD-positive GC has a higher clinical utility compared to the eighth edition of TNM staging.
Multilayered Heparin Hydrogel Microwells for Cultivation of Primary Hepatocytes
Authors: You Jungmok , Shin Dong‐Sik , Patel Dipali , Gao Yandong , Revzin Alexander 
Published: July 2013

AbstractThe biomaterial scaffolds for regenerative medicine need to be rationally designed to achieve the desired cell fate and function. This paper describes the development of hydrogel microstructures for cultivation of primary hepatocytes. Four different micropatterned surfaces are tested: 1) poly(ethyelene glycol) (PEG) microwells patterned on glass, 2) heparin hydrogel microwells patterned on glass, 3) PEG microwells patterned on heparin hydrogel‐coated substrates, and 4) heparin hydrogel microwells patterned on heparin hydrogel‐coated substrates. The latter surfaces are constructed by a combination of micromolding and microcontact printing techniques to create microwells with both walls and floor composed of heparin hydrogel. Individual microwell dimensions are 200 μm diameter and 20 μm in height. In all cases, the floor of the microwells is modified with collagen I to promote cell adhesion. Cultivation of hepatocytes followed by analysis of hepatic markers (urea production, albumin synthesis, and E‐cadherin expression) reveals that the all‐heparin gel microwells are most conducive to hepatic phenotype maintenance. For example, ELISA analysis shows 2.3 to 13.1 times higher levels of albumin production in all‐heparin gel wells compared with other micropatterned surfaces. Importantly, hepatic phenotype expression can be further enhanced by culturing fibroblasts on the heparin gel walls of the microwells. In the future, multicomponent all‐heparin gel microstructures may be employed in designing hepatic niche for liver‐specific differentiation of stem cells.
Development of Luminescent pH Sensor Films for Monitoring Bacterial Growth Through Tissue
Authors: Wang Fenglin , Raval Yash , Chen Hongyu , Tzeng Tzuen‐Rong J. , DesJardins John D. , Anker Jeffrey N. 
Published: July 2013

AbstractAlthough implanted medical devices (IMDs) offer many benefits, they are susceptible to bacterial colonization and infections. Such infections are difficult to treat because bacteria could form biofilms on the implant surface, which reduce antibiotics penetration and generate local dormant regions with low pH and low oxygen. In addition, these infections are hard to detect early because biofilms are often localized on the surface. Herein, an optical sensor film is developed to detect local acidosis on an implanted surface. The film contains both upconverting particles (UCPs) that serve as a light source and a pH indicator that alters the luminescence spectrum. When irradiated with 980 nm light, the UCPs produce deeply penetrating red light emission, while generating negligible autofluorescence in the tissue. The basic form of the pH indicator absorbs more of upconversion luminescence at 661 nm than at 671 nm and consequently the spectral ratio indicates pH. Implanting this pH sensor film beneath 6–7 mm of porcine tissue does not substantially affect the calibration curve because the peaks are closely spaced. Furthermore, growth of Staphylococcus epidermidis on the sensor surface causes a local pH decrease that can be detected non‐invasively through the tissue.