bluuebunny/crossref_metadata_2025_split huggingface dataset:
1277 – The Role Of Gaba-a Receptor In The Synergism Between Ssri And Antipsychotics In Schizophrenia
Authors: Silver H. , Einuch R. , Youdim M. , Weinreb O. 
Published: July 2013

Currently available antipsychotics are often effective against positive symptoms of schizophrenia but have limited effect in treating core features such as negative or cognitive symptoms. New drugs developed on the basis of current dogmas have shown no breakthroughs in effectiveness and novel understandings of the mechanisms responsible for symptom productions and treatment response are needed.Clinical studies have shown that resistant negative symptoms may improve when antipsychotics are augmented with selective serotonin reuptake inhibitor (SSRI). This augmenting effect cannot be explained by summating pharmacological effects of the individual drugs. We reasoned that study of this synergism may reveal novel mechanisms relevant to the core features of schizophrenia and their treatment.Here we present results of in vitro and in vivo laboratory studies showing that the SSRI-Antipsychotic combination, produces unique changes in gamma-aminobutyric acid (GABA)-A receptor and its regulating system which are different from each individual drug. The changes include GABAA receptor phosphorylation, and cellular compartment distribution and changes in proteins modulating GABAA activity including PKC, GSK, ERK and BDNF.Results are also presented from clinical studies showing that SSRI augmentation in schizophrenia patients results in changes in blood mononuclear cell mRNA encoding for GABAA receptor and related proteins which are similar to those observed in the laboratory and associated with clinical improvement. Taken together these findings support the view that GABA A receptor modulation may be part of the mechanism mediating SSRI-antipsychotic synergistic effect ameliorating some core features of schizophrenia.
1278 – Psychological Problems Among Nursing Students: Study From a Nepalese Health Institute
Authors: Shakya D.R. , Lama S. , Shrestha M. , Pandey A.K. , Shyangwa P.M. , Deo B.K. 
Published: July 2013

IntroductionThere is scant data about mental disorders among nursing students from Nepal though it is reported high in other parts.ObjectivesTo measure prevalence of psychiatric problems and to determine common stressors among nursing studentsMethodsThis institute based prevalence study included all certificate and bachelor level nursing students of B. P. Koirala Institute of Health Sciences, Nepal during 2011/12. After informed written consent, ‘semi-structured proforma’, ‘General Health Questionnaire 28’ and ‘Gurmeet Singh's Presumptive stressful life events scale’ were distributed to record sociodemographic/ clinical profiles and other relevant information; to screen psychiatric disorder and to study the stressors respectively. The ‘General Health Questionnaire 28’ gives ‘psychiatric caseness’ to subjects with score 4 or more.ResultsOut of total 200 nursing students, 185 could be enrolled during study period. All subjects were female. They were studying in certificate and in BSc. nursing programs in different academic years. Majority were unmarried, less than 25 years of age, were from urban settings and from nuclear family. Among the enrolled subjects, ‘psychiatric caseness’ was present in 88 (47.57%) subjects, with cut off score of 4. The most common stressful events reported from the ‘Gurmeet Singh's Presumptive stressful life events scale’ were related to exam, study and accommodation to institute life, and average total score of the presumptive stress was 164.8 (minimum 0, maximum 706) in last year.ConclusionMany nursing students suffer from psychological problems and experience the stress, common stressor being related with nursing education.
1284 – Analgesic Activity Of Cage-like Amines Derivatives
Authors: Zlenko H.T. , Zarovnaya I.S. , Palchikov V.A. 
Published: July 2013

ObjectivesIn this work analgesic activity of more than 80 derivatives of cage-like amines is investigated. Carbox-, sulfon- and phosphonamides, ureas, sulfonylureas and aminoalcohols. They were got on the basis of stereochemically homogeneous amines (exo- and endo-2-aminomethylbicyclo[2.2.1]hept-5-enes and their saturated analogues, exo-5-aminomethyl-exo-2,3- epoxybicyclo[2.2.1]heptanes, and also sulfolan, deitiforin and amines of adamantane family by comparison to base amines are plugged into the investigated group.[Figure]Rigid molecules with «fixed» in space substituents used as models for the study of structure-activity relationship of analgesic activity compounds with their chemical structure.MethodsThe investigation of compounds has been carried out on white mise. The acute toxicity (LD50) and analgesic activity («hot plate» method, 55°C) were determined. Explored compounds were entered in a dose equal 1/10 LD50 for 30 minutes prior to testing. Activity of preparations was estimated in % in relation to the control group of animals.ResultsDependence of analgesic activity on the orientation of substituents in norbornene frame is marked: higher activity for endo-stereoisomers than for exo-form. Analgesic action decreases with disappearance of double bond and increase of number of cycles in carbon frame. The deitiforin derivatives are considerably more active than adamantane analogues.ConclusionsMore than 15 patents of Ukraine are got.
1285 – Training Of Bosnia-herzegovina Mental Health Professionals In Group Analysis As The Factor Of Development Of Culture Of Dialogue In The Aftermath Ofthe 1992–1995 War
Authors: Hasanović M. , Izet P. , Avdibegović E. , Kravić N. , Moro L. , Frančišković T. , Gregurek R. , Tocilj G. 
Published: July 2013

AimThe primary objective will focus the first of all on Group Analysis (GA) as the psychotherapy method and theory of group analysis applied particularly in post-war environments. It outlines in particular a Zagreb Institute for GA Training Programme that took place in Tuzla University Clinical Centre, Department of Psychiatry, in Bosnia-Herzegovina (BH) in response to 1992–1995 war, in helping to train mental health workers in GA to enable them to treat psychological trauma symptoms of war survivors.MethodIn the GA education in the period of 16 years mental health professionals employed in mental health services were involved as well as other care employees as General Practitioners, Family physicians, pediatricians, gynecologists and neurosurgeons, psychologists and special educators.ResultsTrainees in education were from greater part of BH, and from several towns from neighborhoods countries. In this way a new room for mutual exchanges of experiences and establishing of cooperation was created. Idea of group analytic treatment of persons with mental health problems spread out on the whole region of BH through this model of education. The future of GA application as a psychotherapy model in BH confirmed through established models of education which are employed inowadays in Tuzla, Sarajevo and Mostar. The future of GA is provided in activities focused on foundations of the Institute for Analysis in Tuzla.ConclusionTraining of Bosnia-Herzegovina mental health workers to effectively use GA with enthusiastic help of GA trainers from Institute for GA Zagreb will develop dialogue culture in postwar BH.
1286 – Therapeutic Compliance In Schizophrenia: The Influence Of Psychotic Symptoms And The Insight
Authors: Arfaoui S. , Zalila H. , Zouari O. , Boussetta A. 
Published: July 2013

IntroductionMedication adherence problems increase hospitalization, morbidity and mortality in the patients with the diagnosis of schizophrenia. Indicators of poor adherence to a medication regimen are a useful resource for physicians to help identify patients who are most in need for interventions to improve adherence.ObjectiveThe objective of this analysis was to find out whether symptoms and insight would predict the therapeutic alliance in the treatment of schizophrenia.MethodWe proceeded to a transverse survey with 95 patients affected by schizophrenia followed in ambulatory in the psychiatric department D of the hospital Razi in Tunisia.ResultsA little more than half of our patients were not observing. The behavior of observance was positively correlated in the sex: the men were more observant that the women. The clinical shape of the disease, the level of insight, the cognitive state as well as the age of the disease are not connected to the degree of compliance. On the other hand, the positive or negative psychotic symptoms are strongly correlated in the therapist alliance.ConclusionThe results of this study suggest that simple measures as the psychoeducation for schizophrenics, and control of the psychotic symptoms advance us on the way of improvement of the therapist alliance and consequently the social reintegration of the patient and his quality of life.
1315 – Screening And Correlates Of Depression And Hba1c In Uae Women With Diabetes
Authors: Hawamdeh S. , Al Makhzoomy I. , Hayajneh Y. 
Published: July 2013

PurposeThe aim was to identify the relationship between sociodemographic characteristics of UAE women with diabetes and depression and to explore any differences between depressed and non-depressed patients in relation to depression glycemic control.Design and methodsOne hundred eighty two patients completed the Beck Depression Inventory-II. Glycemic control was assessed by glycosylated hemoglobin (HbA1c).FindingsNinety two of patients were diagnosed with diabetes mellitus. A statistically significant relationship was found between national status and level of depression among the diabetic sample. At least half of these women showed poor glycemic control (HbA1c levels >7.5). A statistically significant relationship exists between depression status and type of diabetes. There is also a strong relationship between HbA1c level and depression level.Practice implicationsEarly detection of depression among UAE women with diabetes is crucial to enhance treatment regimen adherence and glycemic control.
1320 – State Anxiety, Degree Of Autonomic Symptoms In Medical Students In Various Situations During Studying Process In Correspondence To Gender
Authors: Ivashchenko D. , Yashina Y. , Voznesenskaya T. 
Published: July 2013

IntroductionHigh rates of anxiety symptoms among medical students have been observed in many studies. Autonomic symptoms are indications of anxiety somatization. Reports about gender variations in anxiety and autonomic lability are contradictory and require further researches.ObjectivesTo investigate changes of state anxiety, autonomic symptoms among medical students in various study periods and role of gender variations.Materials and methods54 medical students (28 female and 26 male) of I.M. Sechenov Moscow State Medical University were recruited in this study. Participants were assigned unique identification codes. We used State and Trait Anxiety Inventory (STAI) and Vein’s Autonomic Symptoms Questionnaire (VASQ). State anxiety and autonomic symptoms were defined three times: 2 weeks, one day before the exam and after examination. ANOVA, correlation and t-statistics methods were used to analyze data.ResultsChanging of study situation influenced lability of state anxiety (ANOVA, F= 3,23; p= 0,04). We found gender differences in autonomic symptoms’ penetration in 1st (p= 0.05), 2nd (p< 0.05) and 3rd (p< 0.01) periods; state anxiety varied in 2nd period (p< 0,05) only. Correlation between autonomic symptoms and gender was found in 1st (r= 0,46; p= 0,003) and 2nd (r= 0,901; p< 0.001) periods; correlation between state anxiety and gender was moderate in 2nd period (r= 0,55; p< 0.001).ConclusionsStatistical significance was achieved between a level of anxiety and various studying situations. Correlation between gender and both state anxiety and rate of autonomic symptoms was found. State anxiety and degree of autonomic symptoms was significantly higher in female.
1323 – Cognitive Function In Major Depressive Disorder: The Role Of Symptomatology, Personality And Stress Hormones
Authors: Hori H. , Matsuo J. , Teraishi T. , Fujii S. , Kawamoto Y. , Kinoshita Y. , Ota M. , Hattori K. , Higuchi T. , Kunugi H. 
Published: July 2013

IntroductionIt has been reported that cognitive functioning in major depressive disorder (MDD) can be affected by various factors, such as symptom severity, personality dimensions and stress hormone activity. However, the relative role of each is largely unknown.MethodsSeventy-six non-remitted patients with MDD were recruited. Symptomatology was assessed by the 21-item version of the Hamilton Rating Scale for Depression and the Hopkins Symptom Checklist (HSCL). Personality was assessed by the Temperament and Character Inventory (TCI). Neurocognitive functions, including verbal and visual memory, delayed recall and attention/working memory were measured by the full version of the Wechsler Memory Scale-Revised. Neuroendocrine function was determined by the reactivity of cortisol and dehydroepiandrosterone-sulfate (DHEAS) to the combined dexamethasone/corticotropin releasing hormone test. To quantify cognitive impairments in patients, age-, sex- and education- matched 187 healthy controls were also recruited and administered the same neuropsychological test.ResultsMDD patients performed significantly worse than controls on visual memory and delayed recall. A stepwise multiple regression analysis predicting performance of each cognitive domain from five HSCL dimensions, seven TCI dimensions and hormonal variables, controlling for age, gender and education, revealed that higher cooperativeness was the only significant predictor towards better verbal memory, that less somatization symptoms and lower self-directedness were significant predictors towards better visual memory, and that lower age, less anxiety symptoms and lower DHEAS levels after dexamethasone administration were significant predictors towards better delayed recall.ConclusionsBesides symptomatology, some personality dimensions and neuroendocrine function may, at least partly independently, contribute to memory impairment in MDD.
1344 – PDYN Rs2281285 Variant Is Associated With Alcohol Dependence In Male But Not Female Subjects
Authors: Karpyak V.M. , Winham S.J. , Preuss U.W. , Zill P. , Cunningham J.M. , Walker D.L. , Geske J.R. , Colby C.L. , Abulseoud O.A. , Hall-Flavin D.K. , Loukianova L.L. , Schneekloth T.D. , Frye M.A. , Bazov I. , Heit J.A. , Bakalkin G. , Mrazek D.A. , Biernacka J.M. 
Published: July 2013

IntroductionRecent findings support sex-specific effects of PDYN polymorphisms on association with opioid addiction (Clarke et al. 2012). We have demonstrated that PDYN haplotypes, which include rs2281285, are associated with alcohol dependence and propensity to drink in negative emotional situations (negative craving) (Karpyak et al 2012). The rs2281285 variant may contribute to regulation of alternative PDYN mRNA transcription specific to brain area or physiological condition.ObjectivesTo investigate sex-specific effects of the PDYN rs2281285 variant on risk for alcohol dependence.AimsTo examine the association of the PDYN rs2281285 variant with alcohol dependence in male and female subjects.Methodsrs2281285 was genotyped in the investigation cohort of 816 (554 males) alcohol dependent subjects (DSM-IV-TR) and 1248 (603 males) non-alcoholic controls and in the replication cohort of 467 (347 males) alcohol dependent subjects and 431 (224 males) non-alcoholic controls. Logistic regression models were used to test for sex-specific associations after controlling for age.ResultsAs previously reported, significant association of the PDYN rs2281285 variant with alcohol dependence was found in the investigation (p = 0.008, odds ratio = 1.299), but not the replication cohort (0.223, OR = 0.118). However, sex-specific analyses revealed stronger association in males (p = 0.002, OR = 1.493) but not females (p = 0.684, OR = 1.066) in the investigation cohort, and a trend for association in males (p = 0.086, OR = 1.352) but not females (p = 0.808, OR = 0.947) in the replication cohort.ConclusionsOur findings support association of PDYN rs2281285 variant with alcohol dependence in male but not female subjects. Future studies should investigate functional mechanisms of this effect.
1355 – Borderline Personality Disorder And Schemas Orientate Words Processing - Fmri Study
Authors: Grambal A. , Tüdös Z. , Praško J.P. , Hluštík P. 
Published: July 2013

IntroductionSchemas are self-defeating life patterns of perception, emotion, and physical sensation. Borderline personality disorder patients are characterized by a negative self-image and pronounced vulnerability to negative stimuli activating schemas, which leads to strong negative emotions and conflict in social situations.ObjectivesWe hypothesized that emotional faces and words stimuli will activate amygdala and limbic structures. The activation will be higher in patients compared to healthy controls subjectAimsThe aim of our study is to find the differences of schemas orientate words and emotional faces processing in borderline personality disorder compared to healthy controls. To identify neuronal correlates of negative self-image in BPD patients.MethodFifteen patients suffering from BPD and healthy controls (HC) were studied in fMRI during the exposition of negative schemas related words compared with positive schemas related words and emotional faces (anxious, angry, neutral) compared with fixation points. Psychopathology was assessed using Clinical Global Impression rating scale (CGI), Beck Anxiety Inventory (BAI) and Borderline personality severity index (BPDSI).ResultsSchema-oriented words showed right amygdala activation and strong precuneus and dorsal cingulum activation in BPD group compared with HC. Emotional faces Activations differ in both groups, BPD patient activated more anterolateral brain regions, HC activated more posteromedial areas.ConclusionSchema-oriented words are very hurtful for BPD patients and our fMRI findings confirmed this clinical experience. Processing of emotional faces in patients with borderline personality disorder involve multiple brain regions.SupportedBy the project IGA MZ CR NT 11047-4/2010
1359 – The Role Of Molecular Genetic Polymorphism Drd4, Dat In The Formation Of Personal Anxiety In An Open Population Men 25-64 Years In Siberia
Authors: Gafarov V. , Gromova E. , Gagulin I. , Gafarova A. , Maximov V. , Voevoda M. 
Published: July 2013

As part of WHO «MONICA» in 1994, surveyed a random representative sample of men aged 25-64 years, (n = 657). To assess the level of personal anxiety test was used Spielberger. Studied the association of gene DRD4, DAT with personal anxiety. Men in the open population of Novosibirsk, a high level of personal anxiety - 50.9%. With a high level of anxiety was significantly associated genotype 4 / 6 of the DRD4 gene and genotype 9 / 9 gene DAT.ConclusionIn the open population of men aged 25-64 in Novosibirsk personal anxiety significantly associated with specific polymorphisms of genes DRD4, DAT.Grant ? 11-16-54001 a/T
1364 – Predictive Validity Of The Crisis Triage Rating Scale In The Disposition Of Patients Attending a Nigerian Psychiatric Emergency Unit
Authors: Adeosun I. , Adegbohun A. , Jeje O. , Omoniyi O. 
Published: July 2013

IntroductionIn psychiatric emergencies, there is a high premium on rapid assessment, acuity categorization and objectivity in decisions regarding the disposition of patients. The Crisis Triage Rating Scale (CTRS), a 3-item clinician-rated instrument, has demonstrated validity in determining the disposal of patients in psychiatric emergency settings. However, its utility has not been evaluated in Nigeria.Objectives/aimThis study aimed to assess the validity of the CTRS in predicting the disposal (need for hospitalisation or out-patient treatment) of patients presenting to a psychiatric emergency unit in Nigeria.MethodsThe CTRS was administered to consecutively presenting patients (N=247) at the Emergency Unit of the Federal Neuro-Psychiatric Hospital, Yaba, Lagos. Following a comprehensive psychiatric evaluation, clinicians blinded to the CTRS scores made appropriate decisions regarding the disposal of the patients. The ability of the CTRS to predict the need for hospitalisation at different threshold scores, compared with clinical judgement as criterion, was determined statistically.ResultsThe optimal threshold on the CTRS for detecting the need for hospitalisation is a cut-off score of 9 as it has the best trade-off with a sensitivity of 0.94 and specificity of 0.89. At this threshold, the overall misclassification rate is 0.09, while the area under the Receiver operating characteristics curve is 0.95. The positive predictive validity for the assessment of disposal at the optimum threshold is 0.91.ConclusionThe CTRS is a useful tool in determining the disposition of patients presenting to psychiatric emergency service in Nigeria
1374 – Suicides And The Economic Crisis: The Icelandic Experience
Authors: Oskarsson H. , Bjarnadóttir S. 
Published: July 2013

IntroductionIceland has taken a significant economic toll following the recession starting in late 2008. Unemployment has risen sharply, personal and business bankruptcies too.AimThe aim of this paper to examine the possible impact of the social consequences of the economic crisis on the suicide rate.MethodsThe Icelandic Bureau of Statistics publications, Causes of Death Register, Unemployment Statistics and Purchase Power Index, were utilized. The suicide rate is based on those between 16 and 90 years, per 100.000 inhabitants. The unemployment rate includes those 16-74 years old. Due to the small population size data are presented as three-year averages from 1981-2010.ResultsThe unemployment rate during this period was 0.5-3.0%, with a slightly higer rate in the mid-nineties, until mid- 2008, when it rose rapidly, peaking in 2010 at 8.1%. The suicide rate has declined, particularly during the last ten years, 13.4- 16.5/100.000, with no signs of paralleling the unemployment increase from 2008 onwards. There is one exception, the region with the highest unemployment rate in the past 10 years. The suicide rate there has been high, rising sharply in the past three years. The sample size is small, so this must be interpreted with caution.ConclusionThe suicide rate has been relatively stable in Iceland, and not affected by the current economic crisis. There are signs, though, that that the region hardest hit by the unemployment is at a higher risk for suicides.
1391 – Manic Episode For Consumption Of Energy Drinks
Authors: Hernandez Dorta A. , Quandt Herrera P. , Diaz Marrero G. , Suárez Benitez N. , Vera Barrios E. , Barrau Alonso V. , Gonazalez I. Gonzalez 
Published: July 2013

Introduction and objectivesDescription of a manic episode with psychotic symptoms in a patient by consumption of energy drinks.Aims and methodsLiterature review of the relationship between energy drink consumption and the possibility of suffering a manic episode and description of a clinical case.CaseThis case report describes a patient with no history of psychiatric interest suffers a manic episode with psychotic symptoms after consuming high amounts of energy drinks.Results and conclusionsTo my knowledge, this is one of the few cases that describe a manic episode in relation to the consumption of energy drinks, given this possibility, clinicians should consider asking about the consumption of energy drinks to young people without previous psychiatric history presenting a manic episode.