bluuebunny/crossref_metadata_2025_split huggingface dataset:
Features of the course of the disease, quality of life and cytokine profile in patients with psoriasis vulgaris in the stationary stage and comorbid depression
Authors: Gorlova N. A. , Sherengovskaya Yu. V. , Ravlyuk D. A. , Prokhorov D. V. , Ispiryan M. B. 
Published: July 2024

Aim. To study the characteristics of the course of the disease, quality of life and cytokine profile in patients with psoriasis vulgaris in the stationary stage and depression.Material and methods. A prospective, cross-sectional comparative study involved 154 patients with vulgar psoriasis in the stationary stage; Of these, two groups were formed: 83 patients with comorbid depression and 71 without comorbid depression. The Hamilton scale was used to determine depressive symptoms and severity.Result. Patients with psoriasis vulgaris in the stationary stage and depression were characterized by a younger age (p=0.007), a more severe course of the disease according to the PASI index (p<0.001), visual analogue scale (p=0.014), and a higher frequency of relapses (p=0.012) and a lower level of quality of life according to the DLQI questionnaire (p<0.001), as well as higher values of IL-6 and IL-17 in the blood serum (p=0.011; p=0.001, respectively). An inverse correlation was established between the average total value on the Hamilton scale and the age of the patients (r= –0.61; p=0.002), a direct one – with the average total values on the PASI index (r=0.72; p=0.001), visually analogue scale (r=0.63; p<0.001), DLQI (r=0.69; p=0.001) and IL-17 (r=0.62; p=0.012).Conclusion. In patients with depression, psoriasis vulgaris in the stationary stage is more severe, accompanied by an increase in systemic proinflammatory changes and a more significant decrease in quality of life than in patients without depression. The results obtained must be taken into account when choosing a therapeutic strategy for psoriasis vulgaris, which will personalize treatment and increase its effectiveness.
Experience in treating multifocal alopecia areata in a child with Jak kinase inhibitors
Authors: Dogov A. M. 
Published: July 2024

Alopecia Areata is an autoimmune disease characterized by hair loss mediated by CD8 + T cells. There are no proven effective treatments for alopecia. Recent research on the immunology of hair follicles and recent developments in the field of immunopatogenesis, as well as common ways of developing the disease with other autoimmune disorders have led to research on new treatments, targeted at specific immunological pathways. The so-called JAK-STAT pathway is responsible for transmitting signal from different cytokines to the nucleus of the cell, suggesting that blocking this pathway may be effective in the treatment of alopecia.Study purpose. Presentation of Clinical Case of Multi-focal Alopecia Treatment in Child Oral Tofacitinib.Materials and methods. The study was conducted on the basis of the dermatology department with the laser surgery group of the Center for Pediatric Dermatology and Laboratory of Skin Pathology in children FGAU «National Medical Research Center for Children’s Health» of the Ministry of Health of Russia from April 2021 to November 2022. Severity Alopecia Tool (SALT) was used to determine the severity of the disease in participants. The SALT scale takes into account the percentage of affected hair and divides it into 6 subclasses (S 0 %, S1 <25 %, S2 25–49 %, S3 50–74 %, S4 75–99 % and C5100 %).Results. When oral tofacitinib was administered for 6 months in a 9-year-old patient, full recovery of hair growth on the scalp was observed. No significant abnormalities based on clinical and biochemical blood results were found for the period of treatment and for a year after withdrawal. There was no recurrence of hair loss after the withdrawal of the drug for 12 months.Conclusion. JAK inhibitors can be effective new treatments for alopecia in children. Additional data from randomized controlled trials are required for safe use of JAK inhibitors.
Case Report: Left ventricular apical hypertrophy in a patient with Leopard syndrome mimicking a cardiac tumor: a diagnostic challenge resolved by multimodality imaging
Authors: Liu Hui , Zheng Yue , Huo Huaibi , Peng Xin , Yang Jun , Ma Chunyan , Liu Ting 
Published: July 2024

BackgroundLEOPARD syndrome (LS) is a rare genetic disorder presenting various clinical manifestations from childhood, complicating its diagnosis. In this study, we aim to refine the imaging presentation of LS and emphasize the importance of multimodality imaging in enhancing diagnostic accuracy and preventing serious cardiovascular events.CaseA 41-year-old woman was admitted to hospital with a suspected apical tumor detected by a transthoracic echocardiogram (TTE), which was later identified as apical myocardial hypertrophy through cardiac magnetic resonance imaging (CMR). She had abnormal electrocardiograms from the age of 2 years and freckles around the age of 4 years. In recent years, she has been experiencing exertional dyspnea. Supplemental coronary computer tomography angiography (CCTA) revealed diffuse coronary dilatation. Both multimodality imaging and clinical manifestations led to a suspicion of LS, which was confirmed by subsequent genetic testing. The patient declined further treatment. A 3-month follow-up CMR showed no significant change in the lesion.ConclusionThis report elucidates the diagnostic transition from an initial suspicion of an apical tumor by TTE to a definitive diagnosis of left ventricular apical hypertrophy by CMR in a 41-year-old woman with LS. It underscores the value of multimodality imaging (TTE, CCTA, CMR) in unraveling unusual cardiac manifestations in rare genetic disorders such as LS.
Myocardial injury and clinical outcome in octogenarians after non–ST-elevation myocardial infarction
Authors: Pätz Toni , Stiermaier Thomas , Meusel Moritz , Reinhard Iris , Jensch Philipp-Johannes , Rawish Elias , Wang Juan , Feistritzer Hans-Josef , Schuster Andreas , Koschalka Alexander , Lange Torben , Kowallick Johannes T. , Desch Steffen , Thiele Holger , Eitel Ingo 
Published: July 2024

IntroductionThe aim of this study was to analyze age-associated myocardial injury and clinical outcome after non-ST-elevation myocardial infarction (NSTEMI).MethodsThis prospective, multicenter study consists of 440 patients with NSTEMI enrolled at 7 centers. All patients were treated with primary percutaneous coronary intervention and underwent cardiac magnetic resonance (CMR) imaging 1–10 days after study inclusion. CMR parameters of myocardial injury and clinical outcome were evaluated by creating 2 subgroups: &lt;80 years vs. ≥80 years. The clinical endpoint was the 1-year incidence of major adverse cardiac events (MACE) consisting of death, re-infarction and new congestive heart failure.ResultsElderly patients ≥80 years accounted for 13.9% of the study population and showed a divergent cardiovascular risk profile compared to the subgroup of patients &lt;80 years. CMR imaging did not reveal significant differences regarding infarct size, microvascular obstruction, left ventricular ejection fraction or multidimensional strain analysis between the study groups. At 1-year follow-up, MACE rate was significantly increased in patients ≥80 years compared to patients aged &lt;80 years (19.7% vs. 9.6%; p = 0.019). In a multiple stepwise logistic regression model, the number of diseased vessels, aldosterone antagonist use and left ventricular global longitudinal strain were identified as independent predictors for MACE in all patients, while there was no independent predictive value of age regarding 1-year clinical outcome.ConclusionThis prospective, multicenter analysis shows that structural and functional myocardial damage is similar in younger and older patients with NSTEMI. Furthermore, in this heterogeneous but also clinically representative cohort with reduced sample size, age was not independently associated with 1-year clinical outcome, despite an increased event rate in patients ≥80 years.
Prognostic factors in children and adolescents with differentiated thyroid cancer treated with total thyroidectomy and radioiodine therapy: a retrospective two-center study from China
Authors: Wang Congcong , Li Yutian , Wang Guoqiang , Liu Xinfeng , Zhang Yingying , Lu Chenghui , Li Jiao , Han Na , Wang Zenghua , Si Zengmei , Li Fengqi , Lu Gaixia , Wang Renfei , Wang Xufu 
Published: July 2024

PurposeThis two-center study aimed to explore the main prognostic factors affecting the final disease status in children and adolescents with differentiated thyroid cancer (caDTC) following total thyroidectomy and radioiodine therapy (RAIT).Materials and methodsAll caDTC patients from two centers in the period from 2004-2022 were retrospectively included. At the last follow-up, the patients’ disease status was assessed and classified as an incomplete response (IR) or as an excellent or indeterminate response (EIDR). Then, the difference in preablation stimulated thyroglobulin (ps-Tg) levels between the two groups was compared, and the threshold for predicting IR was determined using receiver operating characteristic (ROC) analysis. Moreover, univariate and multivariate analyses were conducted to identify the factors influencing the patients’ ultimate disease outcomes.ResultsA total of 143 patients (98 females, 45 males; median age 16 years) were recruited. After a median follow-up of 42.9 months, 80 patients (55.9%) exhibited an EIDR, whereas 63 patients (44.1%) exhibited an IR. Patients with an IR had significantly greater ps-Tg levels than did those with an EIDR (median ps-Tg 79.2 ng/mL vs. 9.3 ng/mL, p&lt;0.001). The ROC curve showed that ps-Tg ≥20 ng/mL was the most accurate for predicting IR at the last follow-up. According to multivariate analysis, only ps-Tg, T stage and the therapeutic response to initial RAIT were significantly associated with IR.ConclusionIn caDTC patients, the ps-Tg level, T stage, and response to initial RAIT are critical final outcome indicators.
Research on the economic loss prediction and vulnerability risk zoning of coastal erosion disaster: a case study from Liaoning, China
Authors: Wang Chuanjun , He Yixiong , Ma Gongbo , Wang Weiwei 
Published: July 2024

IntroductionCoastal erosion is widely distributed globally, with sandy coasts being particularly prominent, causing significant economic losses to coastal areas. This study focuses on the coastal areas of Liaoning Province, China, which represent typical sandy beach erosion.MethodsBased on the assessment of coastal erosion disaster losses, a multivariate variable-weight combination prediction model is utilized to predict the losses caused by coastal erosion disasters, providing an effective mathematical modeling approach for predicting such losses. Furthermore, the cluster analysis method is employed to delineate vulnerability risk zones for coastal erosion along the Liaoning Province coast.Results and discussionThe research findings indicate the following: (1) From 2023 to 2025, the losses due to coastal erosion disasters in Liaoning Province are projected to decrease significantly from a scale of 36 million RMB yuan to 5 million RMB yuan; (2) Based on the magnitude of disaster vulnerability risk, the coastal areas of Liaoning Province are categorized into four risk zones: high-risk zones (Jinzhou District), moderately high-risk zones (Zhuanghe City, Wafangdian City, Ganjingzi District), medium-risk zones (Lvshunkou District, Bayuquan), and low-risk zones (Gaizhou City, Suizhong County, Xingcheng City). Recommendations are proposed accordingly: (1) Effective measures should be implemented to mitigate the losses incurred by coastal erosion on land, buildings, infrastructure, agricultural output; (2) In the selection of disaster prevention and control measures,economic factors should be carefully considered in line with the specific circumstances of the losses. Specifically, the economic efficiency of disaster prevention and mitigation measures should be taken into account; (3) Precise efforts should be made to implement coastal erosion disaster prevention and control measures in different regions.
Demonstrating autonomous controls on hardware test beds is a necessity for successful missions to Mars and beyond
Authors: Ezell N. Dianne Bull 
Published: July 2024

NASA and the Department of Defense are planning for a mission to Mars in the 2030s–2040s using nuclear thermal propulsion (NTP). NTP uses a nuclear reactor to heat flowing hydrogen and create thrust. A serious concern for crewed and uncrewed missions to Mars is the loss of reactor control. The reactor startup and initial rocket impulse are initiated in cislunar or near-earth orbital regions; therefore, radio communications between ground control and the NTP engine should occur in real time. However, radio communications can take more than 20 min, depending on planet positions, to reach Mars orbiters from ground control. To address this delay, local autonomous controls are implemented onboard the NTP engine to ensure acceptable operation. However, autonomous controls have not been demonstrated or implemented in research or power reactor contexts because of safety and reliability concerns. To enable autonomous controls development, demonstration, and validation, Oak Ridge National Laboratory has created a nonnuclear hardware-in-the-loop test bed. Sensors throughout the test bed relay system status and hardware response to the user control algorithm, including measurements of temperature, flow, pressure of a loop, control drum position, and drum speed. This paper discusses the development of this facility and user accessibility.
Resilience and mental health among perinatal women: a systematic review
Authors: Hajure Mohammedamin , Alemu Solomon Seyife , Abdu Zakir , Tesfaye Gebremeskel Mulatu , Workneh Yadeta Alemayehu , Dule Aman , Adem Hussen Mustefa , Wedajo Lema Fikadu , Gezimu Wubishet 
Published: July 2024

ObjectiveThis review aimed to assess the current evidence on the relationship between resilience and mental health employed in response to the impacts of mental health.MethodThis review was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA). The protocol of this review was registered on the International Prospective Register of Systematic Reviews (PROSPERO: CRD42023470966). Three authors searched peer-reviewed articles using several electronic databases, including Scopus, PubMed/MEDLINE, Psych Info, EMBASE, and Web of Science, from September to October 2023 and included all the studies from any time until November 1, 2023. The review included all eligible quantitative observational and qualitative studies, irrespective of geographical boundaries.ResultDepression, anxiety, and post-traumatic stress disorders were found to be the most common, but not the only, mental health disorders during the perinatal period, and higher maternal resilience during perinatal periods was found to reduce mental health disorders. It was also found that pregnant women were more resilient to mental health disorders than postpartum women. Tolerance of uncertainty and a positive cognitive appraisal, women’s self-behavior and family functioning, and protective psychosocial resources such as dispositional optimism, parental sense of mastery, self-esteem, gratitude, and forgiveness were found to be the most common mechanisms of resilience among perinatal women. Older age, having an adolescent partner, family income, and distress were found to affect resilience.ConclusionNoting that women’s resilience is an important tool to prevent perinatal mental health disorders, maternal healthcare providers need to counsel perinatal women on resilience-boosting mechanisms, such as applying self-behavior and having social support or close family relationships. It is recommended to counsel or provide psychosocial interventions for the woman’s companion or partner to give strong support for the woman in each of the perinatal periods.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=470966, identifier CRD42023470966.
Food insecurity and its severity among adults receiving antiretroviral therapy in health facilities, northcentral Ethiopia: a multi-facility-based cross-sectional study
Authors: Boneya Dube Jara , Ahmed Ahmed Ali , Yalew Alemayehu Worku 
Published: July 2024

BackgroundFood insecurity plays a crucial role in predicting the spread of HIV due to the adverse effects of coping mechanisms adopted to mitigate it. However, there is a scarcity of context-specific evidence regarding food insecurity among HIV-infected adults. Therefore, this study aimed to assess the context-specific magnitude of food insecurity and associated factors among adults receiving antiretroviral therapy (ART) in health facilities in the North Shewa Zone, Ethiopia, ultimately contributing to the achievement of the 95–95-95 HIV treatment target in the local context.MethodsA multi-facility cross-sectional study was conducted among 865 HIV-infected adults receiving ART and being followed up for their treatment. We included health facilities that provide ART, including four hospitals and six health centers. A log-binomial regression model was fitted to identify the association between food insecurity and independent variables. Adjusted prevalence ratios (APRs) with a 95% confidence interval were computed to measure the strength of the association.ResultsIn this study, 290 (33.7, 95% CI: 30.60, 36.91) of the HIV-infected adults studied had food insecurity during their treatment and follow-up, of which 152 (52.41, 95% CI: 46.64, 58.13) and 110 (37.93%, CI: 32.50, 43.68) of them were found to have severe and moderate forms of food insecurity, respectively. We found that being younger (APR = 2.27, 95% CI: 1.12, 4.60), being female (APR = 1.87, 95% CI: 1.03, 3.39), lacking formal education (APR = 10.79, 95% CI: 14.74, 24.58), having lower educational status (APR = 5.99, 95% CI: 2.65, 13.54), being a daily laborer (APR = 6.90, 95% CI: 2.28, 20.85), having low monthly income (APR = 1.89, 95% CI: 1.11, 3.22), advanced WHO clinical stage (APR = 2.34, 95% CI: 1.08, 5.10), and receiving ART for less than 4 years (AOR = 2.28, 95% CI: 1.09, 4.74) were significantly associated with a high proportion of food insecurity among HIV-infected adults.ConclusionThe magnitude of food insecurity among HIV-infected adults receiving ART was high, with an extremely high magnitude of severe food insecurity. The finding suggests the need for culture- and context-specific nutritional interventions to address the gender dynamics of food insecurity, attention to the early stage of ART, and the integration of strategies to improve educational status and enhance income-generation activities of HIV-infected adults. This requires an emphasis on the link between food insecurity and HIV in Ethiopia’s national food and nutrition policy.
RNA sequencing analysis of sexual dimorphism in Japanese quail
Authors: Park Sinwoo , Kim Jaeryeong , Lee Jinbaek , Jung Sungyoon , Pack Seung Pil , Lee Jin Hyup , Yoon Kyungheon , Woo Seung Je , Han Jae Yong , Seo Minseok 
Published: July 2024

IntroductionJapanese quail are of significant economic value, providing protein nutrition to humans through their reproductive activity; however, sexual dimorphism in this species remains relatively unexplored compared with other model species.MethodA total of 114 RNA sequencing datasets (18 and 96 samples for quail and chicken, respectively) were collected from existing studies to gain a comprehensive understanding of sexual dimorphism in quail. Cross-species integrated analyses were performed with transcriptome data from evolutionarily close chickens to identify sex-biased genes in the embryonic, adult brain, and gonadal tissues.ResultsOur findings indicate that the expression patterns of genes involved in sex-determination mechanisms during embryonic development, as well as those of most sex-biased genes in the adult brain and gonads, are identical between quails and chickens. Similar to most birds with a ZW sex determination system, quails lacked global dosage compensation for the Z chromosome, resulting in directional outcomes that supported the hypothesis that sex is determined by the individual dosage of Z-chromosomal genes, including long non-coding RNAs located in the male hypermethylated region. Furthermore, genes, such as WNT4 and VIP, reversed their sex-biased patterns at different points in embryonic development and/or in different adult tissues, suggesting a potential hurdle in breeding and transgenic experiments involving avian sex-related traits.DiscussionThe findings of this study are expected to enhance our understanding of sexual dimorphism in birds and subsequently facilitate insights into the field of breeding and transgenesis of sex-related traits that economically benefit humans.
Candida tropicalis PMT2 Is a Dispensable Gene for Viability but Required for Proper Interaction with the Host
Authors: Hernández-Chávez Marco J. , Martínez-Duncker Iván , Clavijo-Giraldo Diana M. , López-Ramirez Luz A. , Mora-Montes Héctor M. 
Published: July 2024

Candidemia is an opportunistic mycosis with high morbidity and mortality rates. Even though Candida albicans is the main causative agent, other Candida species, such as Candida tropicalis, are relevant etiological agents of candidiasis and candidemia. Compared with C. albicans, there is currently limited information about C. tropicalis’ biological aspects, including those related to the cell wall and the interaction with the host. Currently, it is known that its cell wall contains O-linked mannans, and the contribution of these structures to cell fitness has previously been addressed using cells subjected to chemical treatments or in mutants where O-linked mannans and other wall components are affected. Here, we generated a C. tropicalis pmt2∆ null mutant, which was affected in the first step of the O-linked mannosylation pathway. The null mutant was viable, contrasting with C. albicans where this gene is essential. The phenotypical characterization showed that O-linked mannans were required for filamentation; proper cell wall integrity and organization; biofilm formation; protein secretion; and adhesion to extracellular matrix components, in particular to fibronectin; and type I and type II collagen. When interacting with human innate immune cells, it was found that this cell wall structure is dispensable for cytokine production, but mutant cells were more phagocytosed by monocyte-derived macrophages. Furthermore, the null mutant cells showed virulence attenuation in Galleria mellonella larvae. Thus, O-linked mannans are minor components of the cell wall that are involved in different aspects of C. tropicalis’ biology.
36th Conference "New in Transfusiology: Regulatory Documents and Technologies": What is Changing?
Authors: Жибурт Е.Б. , Хамитов Р.Г. , Похабов Д.С. , Кузьмин Н.С. , Мадзаев С.Р. , Шалыгин Л.Д. , Шестаков Е.А. 
Published: July 2024

В статье обобщены материалы 36-й конференции «Новое в трансфузиологии: нормативные документы и технологии» (Сочи, 2024). Проанализированы данные по производственной и клинической трансфузиологии, иммунологической и инфекционной безопасности в службе крови, производству препаратов плазмы крови, доказательным исследованиям в трансфузиологии.
The article summarizes the materials of the 36th conference "New in Transfusiology: Regulatory Documents and Technologies" (Sochi, 2024). Data on blood collection and transfusion, immunological and infectious safety in the blood service, the production of blood plasma products, and evidence-based research in transfusiology were analyzed.
Diagnosis and Treatment of Primary Immune Thrombocytopenia. Literature Review
Authors: Муха Л.А. , Панкрашкина М.М. , Виноградова О.Ю. 
Published: July 2024

В работе представлен обзор международных и отечественных данных, касающихся диагностики и терапии первичной иммунной тромбоцитопении.
The paper presents an overview of international and national data concerning the diagnosis and treatment of primary immune thrombocytopenia.