bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiogenic shock due to Gemella morbillorum native mitral valve endocarditis
Authors: Rosa Regis Goulart , Rosa Maria Doroti , Ascoli Aline Maria , Mattioni Mariana , Barth Jose Herve , Teixeira Cassiano 
Published: March 2015

Key Clinical MessageGemella morbillorum is a rare cause of infective endocarditis. Consequently, little is known about the natural course of endocarditis secondary to this pathogen. Herein, we report a case of cardiogenic shock as a complication of acute mitral valve regurgitation following Gemella morbillorum native valve endocarditis.
Hydrosilylation of Ketones, Imines and Nitriles Catalysed by Electrophilic Phosphonium Cations: Functional Group Selectivity and Mechanistic Considerations
Authors: Pérez Manuel , Qu Zheng‐Wang , Caputo Christopher B. , Podgorny Vitali , Hounjet Lindsay J. , Hansen Andreas , Dobrovetsky Roman , Grimme Stefan , Stephan Douglas W. 
Published: March 2015

AbstractThe electrophilic phosphonium salt, [(C6F5)3PF][B(C6F5)4], catalyses the efficient hydrosilylation of ketones, imines and nitriles at room temperature. In the presence of this catalyst, adding one equivalent of hydrosilane to a nitrile yields a silylimine product, whereas adding a second equivalent produces the corresponding disilylamine. [(C6F5)3PCl][B(C6F5)4] and [(C6F5)3PBr][B(C6F5)4] are also synthesised and tested as catalysts. Competition experiments demonstrate that the reaction exhibits selectivity for the following functional groups in order of preference: ketone>nitrile>imine>olefin. Computational studies reveal the reaction mechanism to involve initial activation of the SiH bond by its interaction with the phosphonium centre. The activated complex then acts cooperatively on the unsaturated substrate.
Deeply Reinverted T Wave at 14 Days After the Onset of First Anterior Acute Myocardial Infarction Predicts Improved Left Ventricular Function at 6 Months
Authors: Yokoyama Hiroaki , Tomita Hirofumi , Nishizaki Fumie , Hanada Kenji , Shibutani Shuji , Yamada Masahiro , Abe Naoki , Higuma Takumi , Osanai Tomohiro , Okumura Ken 
Published: March 2015

AbstractBackgroundChanges in electrocardiogram (ECG), especially in the ST segment and T wave, have been recognized as a noninvasive diagnostic tool for coronary flow or myocardial injury.HypothesisA deeply inverted T wave at 14 days after successful percutaneous coronary intervention (PCI) in patients with ST‐segment elevation acute myocardial infarction (STEMI) predicts improved left ventricular (LV) function at 6 months.MethodsWe enrolled 112 consecutive patients (88 men, 63 ± 11 years) with first anterior STEMI who underwent successful PCI. A 12‐lead ECG was recorded everyday from admission through 14 days. After PCI, the first T‐wave inversion was observed within 2 days, and the second occurred at 14 days. We measured the maximum depth of the reinverted T wave (Neg‐T) and divided the patients into 2 groups based on the median value of Neg‐T: the deep group (≥0.6 mV, n = 62) and the nondeep group (<0.6 mV, n = 50).ResultsLV ejection fraction (LVEF) at 14 days did not differ between the 2 groups, but it was greater in the deep than in the nondeep group at 6 months (50.0% ± 8.8% vs 42.5% ± 9.8 %, P < 0.0001). The maximum creatinine phosphokinase‐myocardial band (CPK‐MB) value was significantly lower in the deep than in the nondeep group. Reappearance of the R wave in precordial leads at 6 months was more frequently observed in the deep than in the nondeep group (68% vs 46%, P = 0.02). Multivariate regression analysis showed that the Neg‐T and max CPK‐MB were independent contributors to LVEF at 6 months.ConclusionsA deeply reinverted T wave at 14 days after onset of first anterior STEMI can be a useful predictive marker for improved LV function at 6 months.
Functionalization of Fluorinated Benzenesulfonamides and Their Inhibitory Properties toward Carbonic Anhydrases
Authors: Dudutienė Virginija , Zubrienė Asta , Smirnov Alexey , Timm David D. , Smirnovienė Joana , Kazokaitė Justina , Michailovienė Vilma , Zakšauskas Audrius , Manakova Elena , Gražulis Saulius , Matulis Daumantas 
Published: March 2015

AbstractSubstituted tri‐ and tetrafluorobenzenesulfonamides were designed, synthesized, and evaluated as high‐affinity and isoform‐selective carbonic anhydrase (CA) inhibitors. Their binding affinities for recombinant human CA I, II, VA, VI, VII, XII, and XIII catalytic domains were determined by fluorescent thermal shift assay, isothermal titration calorimetry, and a stopped‐flow CO2 hydration assay. Variation of the substituents at the 2‐, 3‐, and 4‐positions yielded compounds with a broad range of binding affinities and isoform selectivities. Several 2,4‐substituted‐3,5,6‐trifluorobenzenesulfonamides were effective CA XIII inhibitors with high selectivity over off‐target CA I and CA II. 3,4‐Disubstituted‐2,5,6‐trifluorobenzenesulfonamides bound CAs with higher affinity than 2,4‐disubstituted‐3,5,6‐trifluorobenzenesulfonamides. Many such fluorinated benzenesulfonamides were found to be nanomolar inhibitors of CA II, CA VII, tumor‐associated CA IX and CA XII, and CA XIII. X‐ray crystal structures of inhibitors bound in the active sites of several CA isoforms provide structure–activity relationship information for inhibitor binding affinities and selectivity.
Variation in type of adjuvant chemotherapy received among patients with stage I breast cancer: A multi‐institutional study
Authors: Vaz‐Luis Ines , Hughes Melissa E. , Cronin Angel M. , Rugo Hope S. , Edge Stephen B. , Moy Beverly , Theriault Richard L. , Hassett Michael J. , Winer Eric P. , Lin Nancy U. 
Published: March 2015

BACKGROUNDAmong patients with stage I breast cancer, there is significant uncertainty concerning the optimal threshold at which to consider chemotherapy, and when considered, there is controversy regarding whether to consider non‐intensive versus intensive regimens. The authors examined the types and costs of adjuvant chemotherapy received among patients with stage I breast cancer.METHODSThe current study was a prospective cohort study including patients with stage I breast cancer who were treated at a National Comprehensive Cancer Network center from 2000 through 2009. Stage was defined according to the version of the American Joint Committee on Cancer Staging Manual applicable at the time of diagnosis. Stratifying by human epidermal growth factor receptor 2 (HER2), the authors examined the percentage of patients receiving intensive versus non‐intensive chemotherapy regimens and the factors associated with type of chemotherapy administered using multivariable logistic regression. Costs of the most common regimens were estimated.RESULTSOf 8907 patients, 33% received adjuvant chemotherapy. Among those individuals, there was an increase in the use of intensive chemotherapy within the last decade, from 31% in 2000 through 2005 to 63% in 2008 through 2009 (including an increase in the use of the combination of docetaxel, carboplatin, and trastuzumab) among patients with HER2‐positive disease and from 15% in 2000 through 2005 to 41% in 2008 through 2009 among patients with HER2‐negative disease (32% of patients with hormone receptor‐positive and 59% of patients with triple‐negative disease). Among patients treated with non‐intensive regimens, there was an increase in the use of the combination of docetaxel and cyclophosphamide noted, with a decrease in the use of the doxorubicin and cyclophosphamide combination. The choice of regimen varied significantly by institution. The major drivers of cost variation were the incorporation of biologics (eg, trastuzumab) and growth factors, with significant variation even within non‐intensive and intensive regimens.CONCLUSIONSOver time, there was an increase in use of intensive regimens among Stage I breast cancer, with striking institutional and cost variations. Cancer 2015;121:1937–1948. © 2015 American Cancer Society.
Rationally Designed n–n Heterojunction with Highly Efficient Solar Hydrogen Evolution
Authors: Xu Miao , Ye Tiannan , Dai Fang , Yang Jindi , Shen Jingmei , He Qingquan , Chen Wenlong , Liang Na , Zai Jiantao , Qian Xuefeng 
Published: March 2015

AbstractIn most of the reported n–n heterojunction photocatalysts, both the conduction and valence bands of one semiconductor are more negative than those of the other semiconductor. In this work, we designed and synthesized a novel n–n heterojunction photocatalyst, namely CdS‐ZnWO4 heterojunctions, in which ZnWO4 has more negative conduction band and more positive valence band than those of CdS. The hydrogen evolution rate of CdS‐30 mol %‐ZnWO4 reaches 31.46 mmol h−1 g−1 under visible light, which is approximately 8 and 755 times higher than that of pure CdS and ZnWO4 under similar conditions, respectively. The location of the surface active sites is researched and a plausible mechanism of performance enhancement by the tuning of the structure is proposed based on the photoelectrochemical characterization. The results illustrate that this kind of nonconventional n–n heterojunctions is also suitable and highly efficient for solar hydrogen evolution.
A Mn6 Cluster inside a Mn10 Wheel: Characterization of a Mn16‐Oximate Complex Resulting from a Tetrazole‐2‐pyridylketoneoximate Ligand
Authors: Alcazar Laura , Font‐Bardia Mercè , Escuer Albert 
Published: March 2015

AbstractInvited for the cover of this issue is Albert Escuer from the Molecular Magnetism Group, University of Barcelona, Spain. The cover image shows the “cluster inside a ring” core of the complex discussed in the article, whose structure is even more clearly depicted in its shadow. The reaction of an azide anion with 2‐pyridylcyanoxime, mediated by MnII cations, yields a new tetrazole ligand and one high‐nuclearity cluster with an unprecedented core.
Large‐Scale Synthesis of Crystalline 1,2,3,4,6,7‐Hexa‐O‐acetyl‐L‐glycero‐α‐D‐manno‐heptopyranose
Authors: Stanetty Christian , Baxendale Ian R. 
Published: March 2015

AbstractThe higher‐carbon sugarL‐glycero‐D‐manno‐heptose is a major constituent of the inner core region of the lipopolysaccharide (LPS) of many Gram‐negative bacteria. All preparative routes used to date require multiple steps, and scalability has been rarely addressed. Here a highly practical synthesis of crystalline 1,2,3,4,6,7‐hexa‐O‐acetyl‐L‐glycero‐α‐D‐manno‐heptopyranose by a simple four‐step sequence starting fromL‐lyxose is disclosed. Only two recrystallisations are required and the process was demonstrated on a >100 mmol scale, yielding 41 g of the target compound.
New Approach for Voltammetry Near Limit of Detection: Integrated Voltammograms and Reduction of Measurements to an “Ideal” Experiment
Authors: Nigmatullin Raoul R. , Budnikov Herman C. , Sidelnikov Artem V. 
Published: March 2015

AbstractA general approach for quantitative description of voltammograms is suggested. This approach helps to differentiate the presence of traces in a supporting electrolyte used as the background. It is based on the conception of the intermediate model and in the first time it will be applied for description of reproducible data for electroanalytical chemistry, partly for voltammetry. It allows separating the instrumental function (which contains random influence of different uncontrollable factors) and reducing the process of measurements to an ideal experiment, when measurements should be totally reproducible and independent from each other. The suggested theory takes into account all set of random factors which form the remnant current and its dispersion together with elimination of the memory effect that always presents in each voltammetric sensor used. It can be used as corrected apparatus procedure for many multisensory systems.
Towards a smart city based on cloud of things, a survey on the smart city vision and paradigms
Authors: Petrolo Riccardo , Loscrì Valeria , Mitton Nathalie 
Published: March 2015

AbstractSmart city represents one of the most promising, prominent and challenging Internet of Things (IoT) applications [1]. In the last few years, indeed, the smart city concept has played an important role in academic and industry fields, with the development and deployment of various middleware platforms and IoT‐based infrastructures. However, this expansion has followed distinct approaches creating, therefore, a fragmented scenario, in which different IoT ecosystems are not able to communicate between them. To fill this gap, there is a need to re‐visit the smart city IoT semantic and to offer a global common approach. To this purpose, this paper browses the semantic annotation of the sensors in Cloud, and innovative services can be implemented and considered by bridging Cloud of Things (CoT) and IoT. Things like semantic will be considered to perform the aggregation of heterogeneous resources by defining the CoT paradigm. We survey the smart city vision, providing information on the main requirements and highlighting the benefits of integrating different IoT ecosystems within Cloud under this new CoT vision. This paper also discusses relevant challenges in this research area. Copyright © 2015 John Wiley & Sons, Ltd.
Chemotaxonomic value of essential oil components in liverwort species. A review
Authors: Ludwiczuk Agnieszka , Asakawa Yoshinori 
Published: March 2015

AbstractA number of liverwort species are known to emit volatile terpenoids and simple aromatic compounds when crushed. The characteristic odour of these spore‐forming plants is associated with oil body constituents. Secondary metabolites, which constitute the oil bodies, are also of value for taxonomic investigations. Liverworts have yielded a rich array of secondary metabolites. Many of these compounds are characterized by unique structures, and some of them have not been found in any other plants, fungi, or marine organisms. Gas chromatographic profiling of the volatile extracts obtained from the liverworts has been applied with success in differentiating liverworts species, and also used to resolve the taxonomic problems at genus and family level. Due to the fact that liverworts are morphologically very small and it is difficult to collect a sufficient amount of plant material, there are few research data on the composition of the essential oils obtained from these plants. Nevertheless, the available data indicate that, as in the case of aromatic plants, the components present in essential oils obtained from the liverworts can be used in chemosystematic studies of this plant group. The aim of this paper is to show whether: (i) there are differences in the essential oils composition between different liverwort species; (ii) it is possible to find chemical markers characteristic for the analysed liverwort species; and (iii) the data derived from an analysis of the essential oils are in accordance with the data received from volatile extracts. Copyright © 2015 John Wiley & Sons, Ltd.
A Powerful Approach to Test an Optimally Weighted Combination of Rare Variants in Admixed Populations
Authors: Wang Xuexia , Zhang Shuanglin , Li Yun , Li Mingyao , Sha Qiuying 
Published: March 2015

ABSTRACTPopulation stratification has long been recognized as an issue in genetic association studies because unrecognized population stratification can lead to both false‐positive and false‐negative findings and can obscure true association signals if not appropriately corrected. This issue can be even worse in rare variant association analyses because rare variants often demonstrate stronger and potentially different patterns of stratification than common variants. To correct for population stratification in genetic association studies, we proposed a novel method to Test the effect of an Optimally Weighted combination of variants in Admixed populations (TOWA) in which the analytically derived optimal weights can be calculated from existing phenotype and genotype data. TOWA up weights rare variants and those variants that have strong associations with the phenotype. Additionally, it can adjust for the direction of the association, and allows for local ancestry difference among study subjects. Extensive simulations show that the type I error rate of TOWA is under control in the presence of population stratification and it is more powerful than existing methods. We have also applied TOWA to a real sequencing data. Our simulation studies as well as real data analysis results indicate that TOWA is a useful tool for rare variant association analyses in admixed populations.
Image Retrieval with Textual Label Similarity Features
Authors: Sagae Alicia , Fahlman Scott E. 
Published: March 2015

SummaryThis article presents a knowledge‐based solution for retrieving English descriptions of images. We analyse the errors made by a baseline system that relies on term frequency, and we find that the task requires deeper semantic representation. Our solution is to perform incremental, task‐driven development of an ontology. Ontological features are then applied in a machine‐learning algorithm for ranking candidate image descriptions. This work demonstrates the advantage of combining knowledge‐based and statistical approaches for text retrieval, and it establishes the important result that an empirically tuned task‐specific ontology performs better than a domain‐general resource like WordNet, even on previously unseen examples. Copyright © 2015 John Wiley & Sons, Ltd.
Hirsutenone Directly Targets PI3K and ERK to Inhibit Adipogenesis in 3T3‐L1 Preadipocytes
Authors: Cheong Lai Yee , Suk Sujin , Thimmegowda N. R. , Chung Min‐Yu , Yang Hee , Seo Sang Gwon , Shwetha B. , Kim Jong‐Eun , Kwon Jung Yeon , Kim Bo Yeon , Lee Ki Won 
Published: March 2015

ABSTRACTAdipogenesis is a key driver of the expansion of adipose tissue mass that causes obesity. Hirsutenone (HST) is an active botanical diarylheptanoid present in Alnus species. In this study, we evaluated the effects of HST on adipogenesis, its mechanisms of action and the molecular targets involved. Using Oil Red O staining, we observed that HST dose‐dependently suppresses lipid accumulation during adipogenesis in 3T3‐L1 preadipocytes, concomitant with a decrease in peroxisome proliferator‐activated receptor‐γ (PPARγ), CCAAT/enhancer‐binding protein α (C/EBPα) and fatty acid synthase (FAS) protein expression. This inhibitory effect was largely limited to the early stage of adipogenesis, which includes mitotic clonal expansion (MCE), as evidenced by delayed cell cycle entry of preadipocytes from G1 to S phase. Furthermore, the regulation of MCE was accompanied by suppression of phosphatidylinositol 3‐kinase (PI3K) and extracellular‐regulated kinase (ERK) activity. HST was also shown to bind directly to PI3K and ERK1 in a non‐ATP competitive manner. Our results suggest that HST attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3‐L1 preadipocytes, underscoring the potential therapeutic application of HST in preventing obesity. J. Cell. Biochem. 116: 1361–1370, 2015. © 2015 Wiley Periodicals, Inc.
Regulation of CYBB Gene Expression in Human Phagocytes by a Distant Upstream NF‐κB Binding Site
Authors: Frazão Josias B. , Thain Alison , Zhu Zhiqing , Luengo Marcos , Condino‐Neto Antonio , Newburger Peter E. 
Published: March 2015

ABSTRACTThe human CYBB gene encodes the gp91‐phox component of the phagocyte oxidase enzyme complex, which is responsible for generating superoxide and other downstream reactive oxygen species essential to microbial killing. In the present study, we have identified by sequence analysis a putative NF‐κB binding site in a DNase I hypersensitive site, termed HS‐II, located in the distant 5′ flanking region of the CYBB gene. Electrophoretic mobility assays showed binding of the sequence element by recombinant NF‐κB protein p50 and by proteins in nuclear extract from the HL‐60 myeloid leukemia cell line corresponding to p50 and to p50/p65 heterodimers. Chromatin immunoprecipitation demonstrated NF‐κB binding to the site in intact HL‐60 cells. Chromosome conformation capture (3C) assays demonstrated physical interaction between the NF‐κB binding site and the CYBB promoter region. Inhibition of NF‐κB activity by salicylate reduced CYBB expression in peripheral blood neutrophils and differentiated U937 monocytic leukemia cells. U937 cells transfected with a mutant inhibitor of κB “super‐repressor” showed markedly diminished CYBB expression. Luciferase reporter analysis of the NF‐κB site linked to the CYBB 5′ flanking promoter region revealed enhanced expression, augmented by treatment with interferon‐γ. These studies indicate a role for this distant, 15 kb upstream, binding site in NF‐κB regulation of the CYBB gene, an essential component of phagocyte‐mediated host defense. J. Cell. Biochem. 116: 2008–2017, 2015. © 2015 Wiley Periodicals, Inc.
Protein Kinase C Is Involved in the Induction of ATP‐Binding Cassette Transporter A1 Expression by Liver X Receptor/Retinoid X Receptor Agonist in Human Macrophages
Authors: Huwait Etimad A. , Singh Nishi N. , Michael Daryn R. , Davies Thomas S. , Moss Joe W.E. , Ramji Dipak P. 
Published: March 2015

ABSTRACTThe transcription of the ATP‐binding cassette transporter A1 (ABCA1) gene, which plays a key anti‐atherogenic role, is known to be induced by agonists of liver X receptors (LXRs). LXRs form obligate heterodimers with retinoid X receptors (RXRs) and interact with their recognition sequences in the regulatory regions of key genes implicated in the control of cholesterol, fatty acid and glucose homeostasis. We have previously shown a novel role for c‐Jun N‐terminal kinase (JNK) and phosphoinositide 3‐kinase (PI3K) in the LXRs‐mediated induction of macrophage gene expression. Protein kinase C (PKC) is often found to regulate the action of nuclear receptors and cross talk between this kinase family and JNK and/or PI3K has been shown in several settings. We have, therefore, investigated a potential role for PKC in the action of LXR/RXR agonist 22‐(R)‐hydroxycholesterol (22‐(R)‐HC)/9‐cis‐retinoic acid (9cRA) in THP‐1 macrophages, including the induction of ABCA1 expression. The pan PKC inhibitor bisindoylmaleimide was found to attenuate the induction of ABCA1 protein expression, the activation of the JNK signaling pathway and the stimulation of activator protein‐1 (AP‐1) DNA binding activity in macrophages treated with 22‐(R)‐HC and 9cRA. The role of PKC in the action of these ligands was confirmed further by the use of more isotype‐specific inhibitors. These studies, therefore, reveal a potentially important role for PKC in the action of 22‐(R)‐HC and 9cRA in human macrophages. J. Cell. Biochem. 116: 2032–2038, 2015. © 2015 Wiley Periodicals, Inc.