bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posturografia em idosos com distúrbios vestibulares e quedas
Authors: Macedo Camila , Gazzola Juliana Maria , Caovilla Heloisa Helena , Ricci Natalia Aquaroni , Doná Flávia , Ganança Fernando Freitas 
Published: May 2014

Introdução: A posturografia estática e dinâmica tem sido usada para analisar a habilidade de idosos com disfunção vestibular em manter o equilíbrio corporal em diferentes condições de conflitos sensoriais. O objetivo do exame é quantificar a velocidade de oscilação e o deslocamento do centro de pressão nas condições de conflitos visual, somatossensorial e interação visuo-vestibular, e o limite de estabilidade. Objetivo: Analisar a literatura referente ao controle do equilíbrio corporal em idosos com distúrbios vestibulares por meio de posturografia computadorizada estática e dinâmica. Métodos: Revisão nas bases de dados LILACS, EMBASE, MEDLINE, Scielo, Cochrane, ISI Web of Knowledge e bibliotecas virtuais de teses e dissertações, utilizando as palavras-chave “Idoso”, “Equilíbrio Postural”, “Avaliação”, “Controle Postural”, “Quedas”, “Posturografia”, “Vestibular” e/ou “Tontura” de publicações dos últimos vinte anos. Resultados: Há vários modelos de posturografias que mensuram as respostas posturais e o risco de quedas em indivíduos idosos, perante os diferentes estímulos sensoriais, incluindo a tecnologia de realidade virtual. Os idosos com desequilíbrio corporal, tontura, e/ou com histórico de quedas apresentam pior desempenho que idosos sem queixas, sem histórico de quedas e indivíduos mais jovens. Conclusão: A posturografia é uma valiosa ferramenta para análise quantitativa do controle postural, permitindo a identificação das condições sensoriais nas quais os idosos vestibulopatas apresentam maior instabilidade.
The effects of recent uplift and volcanism on deposition in Mono Lake, California, from seismic‐reflection (CHIRP) profiles
Authors: Colman S. M. , Hemming S. R. , Stine S. , Zimmerman S. R. H. 
Published: May 2014

AbstractAbout 150 km of high‐resolution, seismic reflection (Compressed High‐Intensity Radar Pulse) profiles (approximately 20 m penetration) were collected in Mono Lake in order to define the uppermost sedimentary architecture of the basin, which has been heavily impacted by recent volcanic, tectonic, and climatic processes. The study also provides an important background for ongoing efforts to obtain paleoenvironmental records from sediment cores in the lake. The history of four seismic‐stratigraphic units in the upper 20 m of section are inferred from the data, and the interpretations are generally consistent with previous interpretations of lake history for the past 2000 years, including a major lowstand at 1941 m. No shorelines below the previously documented major lowstand at 1941 m were found. A relatively steep slope segment, whose toe is at about 1918 m, and which occurs on the southern and western margins of the deep basin of the lake, is interpreted as the relict foreset slope of deposition from prograding western tributaries. This topography is unconformably overlain by a unit of interbedded tephra and lake sediments of variable lithology, which contains tephra of the North Mono (600–625 cal yr BP) eruption in its upper part. The tephra‐rich unit is overlain by a mostly massive mudflow deposit that is locally more than 18 m thick and that is distributed in a radial pattern around Paoha Island. The evidence suggests that within the past few hundred years, rapid uplift of Paoha Island through thick, preexisting lake deposits led to widespread slope failures, which created a terrain of disrupted, intact blocks near the island, and a thick, fluid mudflow beyond. As is common in mudflows, the mudflow moved up the depositional slope of the lake floor, terminating against the preexisting slopes, likely in multiple surges. Since about 1700 Common Era, fine‐grained, well‐laminated sediments have accumulated in the deep parts of the lake at anomalously rapid rates, probably driven by continued rapid, small‐scale shedding of sediment from Paoha Island.
Weakening and strengthening structures in the Hadley Circulation change under global warming and implications for cloud response and climate sensitivity
Authors: Su Hui , Jiang Jonathan H. , Zhai Chengxing , Shen Tsaepyng J. , Neelin J. David , Stephens Graeme L. , Yung Yuk L. 
Published: May 2014

AbstractIt has long been recognized that differences in climate model‐simulated cloud feedbacks are a primary source of uncertainties for the model‐predicted surface temperature change induced by increasing greenhouse gases such as CO2. Large‐scale circulation broadly determines when and where clouds form and how they evolve. However, the linkage between large‐scale circulation change and cloud radiative effect (CRE) change under global warming has not been thoroughly studied. By analyzing 15 climate models, we show that the change of the Hadley Circulation exhibits meridionally varying weakening and strengthening structures, physically consistent with the cloud changes in distinct cloud regimes. The regions that experience a weakening (strengthening) of the zonal‐mean circulation account for 54% (46%) of the multimodel‐mean top‐of‐atmosphere (TOA) CRE change integrated over 45°S–40°N. The simulated Hadley Circulation structure changes per degree of surface warming differ greatly between the models, and the intermodel spread in the Hadley Circulation change is well correlated with the intermodel spread in the TOA CRE change. This correlation underscores the close interactions between large‐scale circulation and clouds and suggests that the uncertainties of cloud feedbacks and climate sensitivity reside in the intimate coupling between large‐scale circulation and clouds. New model performance metrics proposed in this work, which emphasize how models reproduce satellite‐observed spatial variations of zonal‐mean cloud fraction and relative humidity associated with the Hadley Circulation, indicate that the models closer to the satellite observations tend to have equilibrium climate sensitivity higher than the multimodel mean.
Development of a disposable electrode modified with carbonized, graphene‐loaded nanofiber for the detection of dopamine in human serum
Authors: Ekabutr Pongpol , Sangsanoh Pakakrong , Rattanarat Poomrat , Monroe Charles W. , Chailapakul Orawon , Supaphol Pitt 
Published: May 2014

ABSTRACTA one‐step electrode surface modification is proposed in which a disposable, screen‐printed carbon electrode is functionalized with carbonized, electrospun polyacrylonitrile (PAN)‐loaded graphene (G) nanoparticles to form a composite, CPAN5G‐4x. The electrochemical behavior of the CPAN5G‐4x electrode was examined by cyclic voltammetry and electrochemical impedance spectroscopy. Scanning electron microscopy and X‐ray diffraction were used to characterize the surface morphology and physical properties of the carbonized composite nanofibers before and after modification. The modified electrode was found to be effective for the detection of dopamine (DA) using square‐wave voltammetry (SWV) in the presence of interfering substances such as ascorbic acid and uric acid. With the addition of sodium dodecyl sulfate (SDS) to an optimized solution of phosphate‐buffered saline (PBS) at a pH of 2, the fabricated electrode exhibited enhanced electrocatalytic activity toward the oxidation of DA relative to PBS without SDS at a pH of 7.4. The SWV current displayed a linear response to DA concentrations ranging from 0.5 to 100 μM, with a limit of detection of 70 nM (S/N = 3) and a sensitivity of 1.4258 μA μM−1 cm−2. Finally, the CPAN5G‐4x electrode was used to determine DA levels in human serum. The modified electrode can potentially be harnessed for further electrochemical biosensor applications. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40858.
Determination of hydroquinone using poly(3‐methylthiophene) synthesized electrochemically on pt electrode in methylene chloride
Authors: Kavanoz Muammer , Bük Ufuk , Ülker Emine 
Published: May 2014

ABSTRACTPoly(3‐methylthiophene) (P3MT) film was synthesized by potentiodynamic method on Pt electrode in methylene chloride solution containing 0.10M tetrabuthlammonium perchlorate supporting electrolyte and used for the determination of hydroquinone (HQ) with amperometric I–t method in solution consisting of NaHSO4/Na2SO4 (SBS; pH 2.0). This modified electrode has a lower working potential and good operational stability due to reducing electrode fouling when compared with the direct oxidation of HQ at the bare Pt electrode. Limit of detection, limit of quantification, and the linear response range were found to be 1.32 × 10−5 mM, 4.41 × 10−5 mM, and between 4.41 × 10−5 – 50.0 mM (R2 = 0.997), at 0.50 V versus saturated calomel electrode, respectively. HQ determination in complex matrix was checked using real samples to demonstrate the applicability of modified electrode. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40859.
75 Jahre Schiffshebewerk in Rothensee
Authors: Braun Michael 
Published: May 2014

AbstractVier Jahre nach der Inbetriebnahme des Schiffshebewerkes in Niederfinow hat in Deutschland in Rothensee ein weiteres solches Ingenieurbauwerk den Betrieb aufgenommen. Im Gegensatz zu ersterem hat die Anlage in Rothensee nicht diese Aufmerksamkeit erlangt. Dabei ist sie in stahlbaumäßiger Hinsicht mindestens genauso interessant. Das Bauwerk versieht noch heute anstandslos seinen Dienst.For 75 years shiplift of RothenseeIn 1934 a ship lift in Niederfinow/Germany starts work. Four years later another similar facility in Rothensee near Magdeburg went into action. Both projects were quite different in their public perceptions all the time although the later is from the point of engineering view very interesting at all. The Rothensee facility is full on duty today.
Fährverbindung Osttimor – eine Machbarkeitsstudie
Authors: Schwarz Oliver , Hader Arnulf , Berger Harald 
Published: May 2014

AbstractIm Rahmen der deutsch‐timoresischen Partnerschaft im maritimen Sektor wurde auf Initiative des timoresischen Ministers für Transport die Erstellung einer Machbarkeitsstudie für eine zusätzliche Fährverbindung in dem Inselstaat ausgeschrieben.Ziel der neuen Fährverbindung ist es, die ökonomische Entwicklung von Timor‐Leste zu fördern sowie die Lebensgrundlage der Bevölkerung zu verbessern. Im Rahmen der Machbarkeitsstudie wurde, ergänzend zu der bereits bestehenden Fährverbindung, welche die Hauptstadt Dili mit der westlich gelegenen Enklave Oecussi und der vorgelagerten Insel Ataúro verbindet, ein Konzept für eine neue Anbindung zwischen der Nord‐ und Südküste entwickelt.Die Studie behandelt die technische und ökonomische Machbarkeit der Fährverbindung, das Herausarbeiten potenzieller Fähranleger entlang der Route sowie die konzeptionelle Konstruktionsart der Fähre. Die Entwürfe für die Fähre wie auch für die Anleger basieren auf zuverlässigen und nachhaltigen Lösungen.Ferry connection in Timor‐Leste – Feasibility studyIn the framework of the German‐Timorese financial cooperation in the maritime sector, the Timorese Minister of Transport has launched a tender for the elaboration of a feasibility study for an additional ferry link in the island state.The aim of the new ferry link is to foster the economic development of Timor‐Leste as well as to improve the living conditions of the Timorese population.As a complement to the already existing ferry link between Dili, the enclave of Oecussi on the north west coast of the island and the Ataúro Island, the feasibility study comprises a concept for a new ferry link between the north and south coast of Timor‐Leste.The study covers the technical and economic feasibility of the new ferry link, the identification of potential ferry landing sites along the route as well as the conceptual design of the ferry. All design options for ferry and landing sites are based on reliable and sustainable approaches.
Ein Beitrag zum Teilsicherheitsbeiwert für Wasserdruck
Authors: Kunz Claus 
Published: May 2014

AbstractDurch die Umstellung im konstruktiven Ingenieurbau auf das Teilsicherheitskonzept der Eurocodes wurde im Zuge der Überarbeitung der DIN 19702 der Teilsicherheitsbeiwert von Wasser überlegt und hergeleitet. Wasser ist eine spezifische, in der Regel veränderliche Leiteinwirkung von Wasserbauwerken, teilweise aber auch von geotechnischen Bauwerken, und unterscheidet sich von typischen veränderlichen Einwirkungen wie z. B. Verkehrslasten oder auch klimatischen Lasten wie Wind und Schnee. Wasserdruck ist eine Funktion des Wasserstands, dessen Schwankungen die eigentliche Unsicherheit, die durch eine Extremwertverteilung statistisch abgebildet wird, bedeuten. Die probabilistische Untersuchung typischer Wasserstände führte zur generalisierten Ermittlung von Teilsicherheitsbeiwerten ungünstiger veränderlicher Wasserdruck‐Einwirkungen für DIN 19702, aber auch zur Einschätzung von Wasser als quasi‐ständige Einwirkung. Darüber hinaus lässt sich aus der Sicherheitsbetrachtung das mechanische Verständnis für die Einwirkung Wasser näher beleuchten und gegebenenfalls für eine realistische Schnittgrößen‐Ermittlung nutzen.Contribution to a partial safety factor for water pressureDue to the change of structural engineering codes to the partial safety concept of the Eurocodes the partial safety factor of water has been investigated and derived for the revision of DIN 19702. Water is a specific, usually varying key action for hydraulic structures, but sometimes also for geotechnical structures, and differs from typical variable actions such as traffic loads or climatic loads such as wind and snow. Water pressure is a function of the water level, the fluctuations means the actual uncertainty, which is imaged by a statistically extreme value distributions. The probabilistic analysis of typical water levels led to generalized determination of partial safety factors for a unfavorable varying water pressure influences within DIN 19702, but also for evaluating water as a quasi‐permanent action. In addition, the mechanical understanding of the action effect of water pressure is discussed and might be used, where appropriate, for a realistic effect analysis for structural design.
Symptomatic hepatic hydrothorax successfully treated with transjugular intrahepatic portosystemic shunt (TIPS)–role of titration of portosystemic gradient reduction to avoid post‐TIPS encephalopathy
Authors: Krishnamoorthy T. L. , Taneja M. , Chang P. E. 
Published: May 2014

Key Clinical MessageWe describe a challenging case of hepatic hydrothorax secondary to nonalcoholic steatohepatitis cirrhosis. Our management involved successfully treating the hydrothorax with a transjugular intrahepatic porto‐systemic shunt but having to manage the subsequent complication of hepatic encephalopathy. We conclude with a review of the available literature.
Birth of a boy with isolated short stature after prenatal diagnosis of a Xp22.3 nullosomy due to an inherited t(X;15) (p22.3;p10) translocation
Authors: Blondeel E. , Molina‐Gomes D. , Bouhanna P. , Fauvert D. , Crosnier H. , Dessuant H. , Vialard F. 
Published: May 2014

Key Clinical MessageTranslocations between X and acrocentric chromosomes are rare. We report on the inheritance of a familial t(X;15)(p22.3;p10) translocation in a fetus referred for short long bones. Cytogenetic analysis revealed an unbalanced translocation combined with a three‐gene nullosomy. After genetic counseling, a prognosis was established and a healthy boy was delivered.
Characterization of New Specific Copper Chelators as Potential Drugs for the Treatment of Alzheimer’s Disease
Authors: Nguyen Michel , Robert Anne , Sournia‐Saquet Alix , Vendier Laure , Meunier Bernard 
Published: May 2014

AbstractThe non‐controlled redox‐active metal ions, especially copper, in the brain of patients with Alzheimer disease (AD) should be considered at the origin of the intense oxidative damage in the AD brain. Several bis(8‐aminoquinoline) ligands, such as 1 and PA1637, are able to chelate Cu2+ with high affinity, and are specific chelators of copper with respect to iron and zinc. They are able to efficiently extract Cu2+ from a metal‐loaded amyloid. In addition, these tetradentate ligands are specific for the chelation of Cu2+ compared with Cu+. Consequently, the copper ion is easily released from the bis(8‐aminoquinoline) ligand under reductive conditions, and can be trapped again by a protein having some affinity for copper such as human serum albumin (HSA) proteins. In addition, the copper is not efficiently released from [Cu(CQ)2] in reductive conditions. The catalytic production of H2O2 by [Cu2+‐Aβ1−28]/ascorbate is inhibited in vitro by the bis(8‐aminoquinoline) 1, suggesting that 1 should be able to play a protective role against oxidative damages induced by copper‐loaded amyloids.
Quasi‐static image‐based immersed boundary‐finite element model of left ventricle under diastolic loading
Authors: Gao Hao , Wang Huiming , Berry Colin , Luo Xiaoyu , Griffith Boyce E. 
Published: May 2014

SUMMARYFinite stress and strain analyses of the heart provide insight into the biomechanics of myocardial function and dysfunction. Herein, we describe progress toward dynamic patient‐specific models of the left ventricle using an immersed boundary (IB) method with a finite element (FE) structural mechanics model. We use a structure‐based hyperelastic strain‐energy function to describe the passive mechanics of the ventricular myocardium, a realistic anatomical geometry reconstructed from clinical magnetic resonance images of a healthy human heart, and a rule‐based fiber architecture. Numerical predictions of this IB/FE model are compared with results obtained by a commercial FE solver. We demonstrate that the IB/FE model yields results that are in good agreement with those of the conventional FE model under diastolic loading conditions, and the predictions of the LV model using either numerical method are shown to be consistent with previous computational and experimental data. These results are among the first to analyze the stress and strain predictions of IB models of ventricular mechanics, and they serve both to verify the IB/FE simulation framework and to validate the IB/FE model. Moreover, this work represents an important step toward using such models for fully dynamic fluid–structure interaction simulations of the heart. © 2014 The Authors. International Journal for Numerical Methods in Engineering published by John Wiley & Sons, Ltd.
Neuropsychiatric symptom clusters targeted for treatment at earlier versus later stages of dementia
Authors: Rockwood Kenneth , Mitnitski Arnold , Richard Matthew , Kurth Matthias , Kesslak Patrick , Abushakra Susan 
Published: May 2014

ObjectiveTo characterize clusters of neuropsychiatric symptoms targeted for tracking the disease course in people with dementia, in relation to stage.MethodsBaseline symptoms from 2922 subjects from two datasets (one clinic based, one online) were aggregated. Common neuropsychiatric symptoms identified by patients/carers as targets of treatment using a dementia SymptomGuide™ were selected. The Global Deterioration Scale was used for clinic staging, and an artificial neural network algorithm, for staging online subjects. Symptom clusters were detected using multiple correspondence analysis and connectivity graph analysis based on relative risk (RR). In a connectivity graph, each pair of nodes (representing symptoms) is connected if their co‐occurrence is statistically significant; direction is indicated as positive if RR > 1 and negative otherwise.ResultsNeuropsychiatric symptoms were targeted for treatment in 1072 patients (37%). Agitation (37%) and sleep disturbances (28%) were most common symptoms. One cluster (in people with cognitive impairment, no dementia (CIND) or mild dementia) showed significant co‐occurrence of anxiety and restlessness; decreased initiative was chiefly seen in isolation. A second cluster (in moderate/severe dementia) was defined by significant co‐occurrence of delusions and hallucinations with sleep disturbances; in these subjects, decreased initiative was related to aggression.ConclusionsTwo analytical methods identified neuropsychiatric symptom clusters targeted to track the disease course. In CIND/mild dementia, a profile of decreased initiative distinct from depression suggests possible executive dysfunction. In moderate/severe dementia, targets more reflected psychotic symptoms. Visual data displays allow the relationships between multiple symptoms to be considered simultaneously, which commonly is how they present in patients. Copyright © 2014 John Wiley & Sons, Ltd.
Boosted activation of right inferior frontoparietal network: A basis for illusory movement awareness
Authors: Cignetti Fabien , Vaugoyeau Marianne , Nazarian Bruno , Roth Muriel , Anton Jean‐Luc , Assaiante Christine 
Published: May 2014

AbstractThe feeling of illusory movement is considered important in the study of human behavior because it is deeply related to motor consciousness. However, the neural basis underlying the illusion of movement remains to be understood. Following optimal vibratory stimulation of muscle tendon, certain subjects experience illusory movements while others do not. In the present fMRI study, we sought to uncover the neural basis of illusory movement awareness by contrasting a posteriori these two types of subjects. Examining fMRI data using leave‐one‐subject‐out general linear models and region of interest analyses, we found that a non‐limb‐specific associative network, including the opercular part of the right inferior frontal gyrus and the right inferior parietal lobule, was more active in subjects with illusions. On the other hand, levels of activation in other brain areas involved in kinaesthetic processing were rather similar between the two subsamples of subjects. These results suggest that activation of the right inferior frontoparietal areas, once passed a certain threshold, forms the basis of illusory movements. This is consistent with the global neuronal workspace hypothesis that associates conscious processing with surges of frontoparietal activity. Hum Brain Mapp 35:5166–5178, 2014. © 2014 Wiley Periodicals, Inc.
Structural brain changes in early‐onset and late‐onset depression: An update of volumetric MRI findings
Authors: Tittmann Mandy , Günther Thomas , Sacher Julia , Himmerich Hubertus , Villringer Arno , Hegerl Ulrich , Schönknecht Peter 
Published: May 2014

ABSTRACTEarly‐onset (EOD) and late‐onset depression (LOD) are associated with different neuropsychological syndromes and structural brain changes. In this article, neuroimaging studies examining structural brain changes in elderly depressed patients are reviewed. The presented findings support current assumptions that depression in the elderly generally is associated with volume reductions in brain structures, notably in the hippocampus and the orbitofrontal cortex (OFC). Concerning structural cerebral differences between EOD and LOD, the review yielded conflicting results—only for OFC, but not for amygdala or hippocampus, pronounced effects in LOD than in EOD can be assumed. © 2014 Wiley Periodicals, Inc. Int J Imaging Syst Technol, 24, 149–160, 2014