bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between new insertion of a long‐term enteral feeding tube and mortality in adults admitted to the hospital with aspiration: A retrospective cohort study
Authors: Bai Anthony D. , Srivastava Siddhartha , Leung Marie , Johnson Heather , Verma Amol A. , Razak Fahad 
Published: August 2024

AbstractBackgroundWe aimed to describe the association between insertion of a new long‐term enteral feeding tube during admission for aspiration and in‐hospital mortality.MethodsThis retrospective cohort study across 28 Canadian hospitals from 2015 to 2022 included consecutive patients who were admitted for aspiration. Patients were categorized based on new long‐term enteral feeding tube insertion during hospital stay or not. The primary outcome was the time to death in hospital. Secondary outcomes included time to discharge alive and hospital readmission for aspiration within 90 days. We used propensity score weighting to balance covariates, and a competing risk model to describe in‐hospital death and discharge.ResultsOf 12,850 patients admitted for aspiration, 852 (6.6%) patients received a long‐term enteral feeding tube. In the hospital, 184 (21.6%) and 2489 (20.8%) patients in the enteral feeding tube group and no enteral feeding tube group died, respectively. Within 90 days of discharge, 127 (14.9%) and 1148 (9.6%) patients in the enteral feeding tube and no enteral feeding tube group were readmitted for aspiration, respectively. After balancing covariates, an enteral feeding tube was associated with a similar in‐hospital mortality risk (subdistribution hazard ratio [sHR] = 1.05, 95% CI = 0.89–1.23; P = 0.5800), longer time to discharge alive (sHR = 0.58, 95% CI = 0.54–0.63; P < 0.0001), and a higher risk of readmission (risk difference = 5.0%, 95% CI = 2.4%–7.6%; P = 0.0001).ConclusionInitiation of long‐term enteral tube feeding was not uncommon after admission for aspiration and was not associated with an improvement in the probability of being discharged alive from the hospital or readmitted for aspiration.
Focused ultrasound and concurrent chemotherapy for the treatment of advanced pancreatic cancer: A systematic review
Authors: Bennett Sean , Hirpara Dhruvin H. , Raphael Michael , Karanicolas Paul J. 
Published: August 2024

AbstractBackground and ObjectivesThe combination of focused ultrasound (FUS) and chemotherapy is a novel treatment for pancreatic cancer. This paper reviews the literature on this combined therapy.MethodsThe medical literature was searched according to PRISMA guidelines. Inclusion criteria were any study of patients with pancreatic cancer undergoing treatment with FUS and chemotherapy. Data extracted included stage, radiologic response, resection rate, survival, and adverse events.ResultsThe initial search yielded 212 citations; 10 studies met inclusion criteria (9 retrospective cohorts; 1 randomized trial). A total of 631 patients received FUS + chemotherapy; 63.6% being stage 4, and 29.7% stage 3. Patient selection, FUS parameters, and chemotherapy used were all heterogeneous. Overall survival ranged from 7.4 to 21.6 months, radiologic response rate was 44.1%, and 24.4% of stage 3 patients underwent resection. All four studies with a comparison group demonstrated improved survival. FUS + chemotherapy decreased pain in 69.7% of patients. Severe adverse events occurred in 0.65%.ConclusionsThe literature on combined FUS and chemotherapy for pancreatic cancer is heterogeneous. There is good evidence that adverse events are low, and that it provides effective palliation. There is evidence to suggest oncologic benefit, however, this is subject to selection bias and prospective trials are needed.
Assessing Bed and Breakfast Customers' Behavioral Intention Based on Self‐Congruity Theory
Authors: Tao Shuting , Jia Mengke , Jin Xiaoyu 
Published: August 2024

ABSTRACTCustomers' self‐congruity has been verified to be an important antecedent of their satisfaction or loyalty in terms of brand consumption. In the era of the experience economy, effects of customers' self‐congruity as well as subject norm on their attitude and behavioral intention concerning the special form of accommodation, that is, B&Bs have been seldomly studied. Therefore, this study applied self‐congruity theory with subjective norm to explain the phenomenon of increasing interests of B&Bs. As a result, first, self‐image congruity was insignificantly associated with B&B customer attitude. Second, B&B customers' functional congruity positively impacts customers' attitude and subsequential their behavioral intention. Third, customers' behavioral intention was influenced by subjective norm, that is, others' recommendation or suggestion could affect customers' behavioral intention. Collectively, the business operators and investors could develop and establish relative marketing strategies from the angles of subjective norm and functional congruity between customers and B&Bs.
CMTM5 influences Hippo/YAP axis to promote ferroptosis in glioma through regulating WWP2‐mediated LATS2 ubiquitination
Authors: Fan Ye , Zou He‐Qin 
Published: August 2024

AbstractGlioma, a common malignancy, is characterized by high morbidity and mortality. Promoting ferroptosis can delay tumor progression. Here, we aimed to explore the underlying mechanism of ferroptosis in glioma. In vitro and in vivo experiments were conducted using glioma cells and nude mice. The expression of genes and proteins was evaluated by RT‐qPCR, Western blot assay, and immunohistochemical staining. Malignant activities of glioma cells were evaluated using MTT, EdU, and Transwell assays. The levels of Fe2+, lipid reactive oxygen species, and malondialdehyde were determined using commercial kits. The interplays among CMTM5, WWP2, and LATS2 were validated using Co‐immunoprecipitation assay. The UALCAN database predicted downregulation of CMTM5 expression in glioma, and low expression of CMTM5 was associated with poor survival outcomes. CMTM5 overexpression inhibited cell growth and invasion and promoted ferroptosis of glioma cells. Besides, CMTM5 protein interacted with WWP2 protein and decreased WWP2 expression. WWP2 silencing attenuated LATS2 ubiquitination to enhance LATS2 expression and phosphorylation of YAP1. CMTM5 exerted a suppressive effect on cell growth and invasion and promoted ferroptosis of glioma cells by regulating the WWP2/LATS2 pathway. In the in vivo experiments, CMTM5 overexpression suppressed tumor growth and enhanced ferroptosis. CMTM5 regulated Hippo/YAP signaling to inhibit cell growth and invasion and to promote ferroptosis in glioma by regulating WWP2‐mediated LATS2 ubiquitination, thereby attenuating glioma progression.
Multiple DNA Viruses and HPV Integration in Inverted Papilloma and Associated Sinonasal Carcinoma
Authors: Jauhiainen Maria K. , Pyöriä Lari , Viitasalo Sanna , Mohanraj Ushanandini , Aaltonen Leena‐Maija , Söderlund‐Venermo Maria , Hagström Jaana , Mäkitie Antti A. , Perdomo Maria F. , Sinkkonen Saku T. 
Published: August 2024

ObjectivesSinonasal inverted papilloma (IP) has a locally destructive growth pattern, can relapse, and can undergo malignant transformation (IP‐associated sinonasal squamous cell carcinoma (IP‐SNSCC)). Human papillomaviruses (HPV)‐6 and ‐16 are frequently detected in IPs. To clarify the possible roles of other DNA viruses in IPs, we explored viruses not studied in this context before. With the setting of pre‐ and post‐malignant transformation samples, we investigated HPV genomes in depth to assess the integration of HPV into the human genome and the presence of minor intratypic variants.Materials and MethodsWe analyzed 35 IP samples representing 28 individuals, of which six had IP‐SNSCC. For virus screening, we applied qPCR to detect 16 different DNA viruses in three virus families, comprising herpesviruses, parvoviruses, and polyomaviruses. In addition, targeted next generation sequencing (NGS) was used for detailed HPV analysis.ResultsWe detected herpes‐, parvo‐, and polyomaviruses in 13/28 (46%) patients, with codetections of multiple viruses in six (21%) patients. NGS revealed HPV16 DNA in 2/6 IP‐SNSCC and in their respective earlier benign IP samples, as well as in a plasma sample from one of these patients. HPV6 was detected in two IP samples without subsequent malignant transformation. We identified sequence reads containing junctions of HPV6 and HPV16 and host genome suggestive of viral integration. HPV6 and HPV16 minor intratypic variants were present across pre‐ and post‐malignant transformation, with mostly nonsynonymous mutations.ConclusionsMultiple DNA viruses were present in IPs. HPV16 was detected only in IP‐SNSCCs or in tumors that later underwent malignant transformation.Level of Evidence3 Laryngoscope, 135:677–686, 2025
Preoperative Hypoalbuminemia Predicts 30‐day Complications in Head and Neck Microvascular Surgery
Authors: Xu James R. , Kosanam Anish , Arianpour Khashayar , Lamarre Eric D. , Hyland Christopher G. , Ciolek Peter J. 
Published: August 2024

IntroductionHypoalbuminemia, a marker for poor nutritional status, has been associated with postoperative complications, including head and neck cancer surgery. This study investigates the impact of hypoalbuminemia on head and neck microvascular free tissue transfer reconstruction.MethodsThis retrospective cohort study queried the 2005–2021 American College of Surgeons National Surgical Quality Improvement Program databases. Reconstructive cases performed by otolaryngologists (CPT: 15756, 15757, 15758, 15842, 20955, 20956, 20957, 20962, 20969, 20970, 20972, 20973, 43116, 43496, 49006, and 49906) with available preoperative albumin, BMI, and age were included. Hypoalbuminemia was defined as a preoperative albumin <3.5 g/dL. Univariate and multivariable logistic regression were performed.ResultsA total of 3,886 cases met the inclusion criteria, of which 835 (21.5%) had hypoalbuminemia. The hypoalbuminemia cohort was older, had lower BMI, had higher ASA classification, and had worse functional health status. Adjusted multivariable logistic regression showed that hypoalbuminemia was associated with unplanned return to the operating room within 30 days (OR: 1.36, p < 0.01), unplanned reoperation (OR: 1.36, p < 0.01), any complication (OR: 1.77, p < 0.01), surgical complications (OR: 1.94, p < 0.01), and medical complications (OR: 1.34, p = 0.01). Hypoalbuminemia was correlated with a longer hospital stay, superficial surgical site infection, wound dehiscence, transfusion, deep vein thrombosis, and acute renal failure.ConclusionHypoalbuminemia is a risk factor for postoperative complications after microvascular free tissue transfer for head and neck reconstruction. This study suggests that preoperative optimization of hypoalbuminemia may be beneficial for these patients.Level of Evidence3 Laryngoscope, 135:648–656, 2025
Soil desiccation in the context of vegetation restoration: A scientometric analysis
Authors: Azim Rizwan , Wang Qi , Mak‐Mensah Erastus , Zhou Xujiao , Zhang Dengkui , Zhao Xiaole , Qi Wenjia , Zhu Jinhui , Ma Wen , Sadiq Mahran , Liu Bing 
Published: August 2024

AbstractThis research aims to fill the gap in understanding the evolution of soil desiccation studies, focusing on its impact on sustainable crop production in China's Loess Plateau. The study explores trends, influential works, authors, journals, and emerging research areas within the field of soil desiccation. To achieve this, this study pioneers a comprehensive scientometric exploration of soil desiccation. The study analyzed 1952 publications on soil desiccation from January 2013 to December 2023, sourced from the Web of Science. Various co‐citation techniques such as author co‐citation analysis (ACA), document co‐citation analysis (DCA), journal co‐citation analysis (JCA), and keyword analysis are employed. Network development, visualization tools, and text‐mining methods are utilized to discern patterns and relationships within the dataset. Here, for the first time, nine distinct clusters were identified through DCA. The findings reveal the impactful emergence of significant clusters, such as the one focusing on the Loess Plateau, marking a significant advance in our understanding of soil desiccation. Multiple research frontiers or sub‐specialties emerge, including topics such as different vegetation types, the impact on grain yield, water use efficiency, growth, soil water content, hydraulic redistribution, drought, soil moisture, and modeling. This innovative scientometric review of soil desiccation outlines the current scientific and technological trends while identifying knowledge gaps. The findings are beneficial for researchers, graduate students, and professors interested in understanding research trajectories, pivotal publications, and influential scholars shaping this field.
Optimizing observational arrays for biogeochemistry in the tropical Pacific by estimating correlation lengths
Authors: Chu Winnie U. , Mazloff Matthew R. , Verdy Ariane , Purkey Sarah G. , Cornuelle Bruce D. 
Published: August 2024

AbstractGlobal climate change has impacted ocean biogeochemistry and physical dynamics, causing increases in acidity and temperature, among other phenomena. These changes can lead to deleterious effects on marine ecosystems and communities that rely on these ecosystems for their livelihoods. To better quantify these changes, an array of floats fitted with biogeochemical sensors (BGC‐Argo) is being deployed throughout the ocean. This paper presents an algorithm for deriving a deployment strategy that maximizes the information captured by each float. The process involves using a model solution as a proxy for the true ocean state and carrying out an iterative process to identify optimal float deployment locations for constraining the model variance. As an example, we use the algorithm to optimize the array for observing ocean surface dissolved carbon dioxide concentrations (pCO2) in a region of strong air–sea gas exchange currently being targeted for BGC‐Argo float deployment. We conclude that 54% of the pCO2 variability in the analysis region could be sampled by an array of 50 Argo floats deployed in specified locations. This implies a relatively coarse average spacing, though we find the optimal spacing is nonuniform, with a denser sampling being required in the eastern equatorial Pacific. We also show that this method could be applied to determine the optimal float deployment along ship tracks, matching the logistics of real float deployment. We envision this software package to be a helpful resource in ocean observational design anywhere in the global oceans.
Recent Progress in Deep Learning for Improving Coherent Anti‐Stokes Raman Scattering Microscopy
Authors: Yao Bowen , Lin Fangrui , Luo Ziyi , Chen Qinglin , Lin Danying , Yang Zhigang , Li Jia , Qu Junle 
Published: August 2024

AbstractCoherent anti‐Stokes Raman scattering (CARS) microscopy is a powerful label‐free imaging technique that leverages biomolecular vibrations and is widely used in different fields. However, its intrinsic non‐resonant background (NRB) can distort Raman signals and compromise spectral fidelity. Conventional data analysis methods for CARS encounter a bottleneck in achieving high accuracy. Furthermore, CARS requires balancing imaging speed against image quality. In recent years, endeavors in deep learning have effectively overcome these obstacles, advancing the development of CARS. This review highlights the research that applies deep learning to mitigate NRB, classify CARS data for disease identification, and denoise images. Each approach is delineated in terms of network architecture, training data, and loss functions. Finally, the challenges in this field is discussed and using the latest deep learning advancement is suggested to enhance the reliability and efficiency of CARS microscopy.
Aryl‐Ether‐Free Polyaromatics‐Based Alkaline‐Resistant Anion exchange PTFE Composite Membrane
Authors: Iyer Rikhil R. , Boga Karteek , Varga Joseph F. , Wang Huanting , Saito Kei 
Published: August 2024

AbstractNovel aryl‐ether‐free polyaromatics with different‐sized cationic headgroups tethered to the backbone are synthesized via superacid‐catalyzed polycondensations and subsequent Menshutkin quaternization reactions for potential application as anion exchange membranes (AEMs) in electrolysis. Experimentally, the effect of four different heterocycloaliphatic quaternary ammonium cationic headgroups on the AEM properties, such as the hydroxide conductivity, water uptake, swelling ratios and alkaline stability, is fully explored. Thin films are prepared by spin‐coating these AEMs onto porous polytetrafluoroethylene substrates. With a high degree of quaternization, these new aryl‐ether free polyaromatic thin film AEMs achieved high conductivities and good mechanical stability. The highest hydroxide conductivity of 45 mS cm−1 is achieved with excellent alkaline stability and conductivity retention of 96% after 30 days in 1 m KOH at 80 °C. Due to the polytetrafluoroethylene substrates, the swelling ratios and water uptake are relatively small, which ensured the astute dimensional stability of these thin film AEMs. The combined effect of alkaline‐stable cationic headgroups, an aromatic backbone and a robust substrate led to a promising thin‐film AEM.
Erosion wear of the multilayered high velocity oxy‐fuel ceramic coatings on aluminum alloy composite substrate
Authors: Vats A. , Patnaik A. , Meena M. L. , Kukshal V. , Patnaik T. K. 
Published: August 2024

AbstractHigh velocity oxyfuel coatings have been sprayed on aluminium (Al) alloy composites substrate with varying coating thickness and tested for their wear behavior. The density and micro‐ hardness of the coatings found to increase with increase in coating thickness. The air erosion wear test has been conducted using quartz sand of size up to 75 μm as erodent. The steady state experiments indicate that the greatest specific erosion rate is at 60° and minimum at 30°. Due to the presence of interlayer, specific erosion rate decreases with the increase in the thickness of the coatings. Surface topography of the eroded samples indicate a decrease in surface roughness with increase in impact velocity. Thereafter, Taguchi (L16) orthogonal array has been utilized in order to optimize the input parameters. Analysis of variance has been applied to determine the contribution of individual control factors. The results from Taguchi experiments and analysis of variance find the order of dominance of control factors and their individual contribution as: velocity (47.31 %) > coating thickness (29.94 %) > angle (13.26 %) > erodent feed rate (7.65 %). Coatings have exhibited a semiductile wear behavior.
Quercetin inhibits endothelial & hepatocellular carcinoma cell crosstalk via reducing extracellular vesicle‐mediated VEGFR2 mRNA transfer
Authors: Xiong Wei , Zheng Bo , Liu Di , Pu Mo , Zhou Shijie , Deng Ying 
Published: August 2024

AbstractThis study aims to investigate the regulatory effects of quercetin extracellular vesicles (EVs)‐mediated expression of vascular endothelial growth factor receptor 2 (VEGFR2) in hepatocellular carcinoma (HCC)‐derived circulating tumor cells (CTCs) and the underlying mechanisms. CTCs were isolated from patients with pathologically diagnosed HCC, with VEGFR2 expression visualized by fluorescence in situ hybridization (FISH). The human HCC cell line Huh‐7 and SK‐HEP‐1 were used for in vitro studies to assess EVs uptake, VEGFR2 mRNA transfer, invasion, migration, cancer stem cell (CSC) properties, and VEGF secretion. Results showed that VEGFR2 mRNA was commonly expressed in HCC‐CTCs, with a higher incidence in biphenotypic CTCs. Its expression was limited in HCC cell lines, but present in certain liver cells. In vitro experiments confirmed that VEGFR2 mRNA could be transferred to HCC cells via EVs from primary tumor endothelial cells (PTECs), which was impaired by quercetin treatment. Quercetin significantly reduced VEGFR2 mRNA and protein expression in HCC cells, weakened their invasive and metastatic capacities, and diminished VEGFR2‐mediated CSC properties. In vivo, quercetin reduced VEGF secretion, impaired angiogenesis, slowed tumor growth, and decreased the number and proportion of VEGFR2‐positive CTCs. In summary, VEGFR2 mRNA is present in HCC‐CTCs, potentially sourced from PTECs‐derived EVs. Quercetin effectively inhibits VEGFR2 expression, impacting HCC cell invasion, metastasis, and CSC characteristics. Besides, it reduces VEGFR2‐positive CTCs in vivo. These effects support its therapeutic potential in HCC treatment by targeting the angiogenesis and tumor dissemination pathway.
miR‐106b‐5p protects against drug‐induced liver injury by targeting vimentin to stimulate liver regeneration
Authors: Lu Xiaoyan , Yu Lingqi , Zheng Jie , Li Anyao , Li Junying , Lou He , Zhang Wentao , Guo Hui , Wang Yuzhen , Li Xuemei , Gao Yue , Fan Xiaohui , Borlak Jürgen 
Published: August 2024

AbstractUnderstanding the endogenous mechanism of adaptive response to drug‐induced liver injury (arDILI) may discover innovative strategies to manage DILI. To gain mechanistic insight into arDILI, we investigated exosomal miRNAs in the adaptive response to toosendanin‐induced liver injury (TILI) of mice. Exosomal miR‐106b‐5p was identified as a specific regulator of arDILI by comprehensive miRNA profiling. Outstandingly, miR‐106b‐5p agomir treatment alleviated TILI and other DILI by inhibiting apoptosis and promoting hepatocyte proliferation. Conversely, antagomir treatments had opposite effects, indicating that miR‐106b‐5p protects mice from liver injury. Injured hepatocytes released miR‐106b‐5p‐enriched exosomes taken up by surrounding hepatocytes. Vim (encodes vimentin) was identified as an important target of miR‐106b‐5p by dual luciferase reporter and siRNA assays. Furthermore, single‐cell RNA‐sequencing analysis of toosendanin‐injured mouse liver revealed a cluster of Vim+ hepatocytes; nonetheless declined following miR‐106b‐5p cotreatment. More importantly, Vim knockout protected mice from acetaminophen poisoning and TILI. In the clinic, serum miR‐106b‐5p expression levels correlated with the severity of DILI. Indeed, liver biopsies of clinical cases exposed to different DILI causing drugs revealed marked vimentin expression among harmed hepatocytes, confirming clinical relevance. Together, we report mechanisms of arDILI whereby miR‐106b‐5p safeguards restorative tissue repair by targeting vimentin.
APOL1 polymorphisms are not influencing acute coronary syndrome risk in Czech males
Authors: Hubacek Jaroslav A. , Adamkova Vera , Lanska Vera , Stanek Vladimir , Mrazkova Jolana , Gebauerova Marie , Kettner Jiri , Kautzner Josef , Pitha Jan 
Published: August 2024

AbstractBackgroundThe highest mortality and morbidity worldwide is associated with atherosclerotic cardiovascular disease (ASCVD), which has in background both environmental and genetic risk factors. Apolipoprotein L1 (APOL1) variability influences the risk of ASCVD in Africans, but little is known about the APOL1 and ASCVD in other ethnic groups.MethodsTo investigate the role of APOL1 and ASCVD, we have genotyped four (rs13056427, rs136147, rs10854688 and rs9610473) APOL1 polymorphisms in a group of 1541 male patients with acute coronary syndrome (ACS) and 1338 male controls.ResultsIndividual APOL1 polymorphisms were not associated with traditional CVD risk factors such as smoking, hypertension or diabetes prevalence, with BMI values or plasma lipid levels. Neither individual polymorphisms nor haplotypes were associated with an increased risk of ACS nor did they predict total or cardiovascular mortality over the 10.2 ± 3.9 years of follow‐up.ConclusionsWe conclude that APOL1 genetic variability has no major effect on risk of ACS in Caucasians.