bluuebunny/crossref_metadata_2025_split huggingface dataset:
Choosing an appropriate modelling framework for analysing multispecies co-culture cell biology experiments
Authors: Markham Deborah C , Simpson Matthew J , Baker Ruth E 
Published: August 2014

AbstractIn vitrocell biology assays play a crucial role in informing our understanding of the migratory, proliferative and invasive properties of many cell types in different biological contexts. While mono-culture assays involve the study of a population of cells composed of a single cell type, co-culture assays study a population of cells composed of multiple cell types (or subpopulations of cells). Such co-culture assays can provide more realistic insights into many biological processes including tissue repair, tissue regeneration and malignant spreading. Typically, system parameters, such as motility and proliferation rates, are estimated by calibrating a mathematical or computational model to the observed experimental data. However, parameter estimates can be highly sensitive to the choice of model and modelling framework. This observation motivates us to consider the fundamental question of how we can best choose a model to facilitate accurate parameter estimation for a particular assay. In this work we describe three mathematical models of mono-culture and co-culture assays that include different levels of spatial detail. We study various spatial summary statistics to explore if they can be used to distinguish between the suitability of each model over a range of parameter space. Our results for mono-culture experiments are promising, in that we suggest two spatial statistics that can be used to direct model choice. However, co-culture experiments are far more challenging: we show that these same spatial statistics which provide useful insight into mono-culture systems are insufficient for co-culture systems. Therefore, we conclude that great care ought to be exercised when estimating the parameters of co-culture assays.
TACC3–ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
Authors: Gutiérrez-Caballero Cristina , Burgess Selena G. , Bayliss Richard , Royle Stephen J. 
Published: August 2014

AbstractThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto mitotic spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule-binding surface. Recent work indicates that TACC3 can track the plus-ends of microtubules and modulate microtubule dynamics in non-dividing cells via its interaction with ch-TOG. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we describe the molecular interaction between TACC3 and ch-TOG that permits TACC3 recruitment to the plus-ends of microtubules. This TACC3–ch-TOG pool is independent of EB1, EB3, Aurora-A phosphorylation and binding to clathrin. We also describe the distinct combinatorial subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification.
ATP-Dependent Binding Cassette Transporter G Family Member 16 Increases Plant Tolerance to Abscisic Acid and Assists in Basal Resistance against Pseudomonas syringae DC3000
Authors: Ji Hao , Peng Yanhui , Meckes Nicole , Allen Sara , Stewart C. Neal , Traw M. Brian 
Published: August 2014

Abstract
Plants have been shown previously to perceive bacteria on the leaf surface and respond by closing their stomata. The virulent bacterial pathogen Pseudomonas syringae pv tomato DC3000 (PstDC3000) responds by secreting a virulence factor, coronatine, which blocks the functioning of guard cells and forces stomata to reopen. After it is inside the leaf, PstDC3000 has been shown to up-regulate abscisic acid (ABA) signaling and thereby suppress salicylic acid-dependent resistance. Some wild plants exhibit resistance to PstDC3000, but the mechanisms by which they achieve this resistance remain unknown. Here, we used genome-wide association mapping to identify an ATP-dependent binding cassette transporter gene (ATP-dependent binding cassette transporter G family member16) in Arabidopsis (Arabidopsis thaliana) that contributes to wild plant resistance to PstDC3000. Through microarray analysis and β-glucuronidase reporter lines, we showed that the gene is up-regulated by ABA, bacterial infection, and coronatine. We also used a green fluorescent protein fusion protein and found that transporter is more likely to localize on plasma membranes than in cell walls. Transferred DNA insertion lines exhibited consistent defective tolerance of exogenous ABA and reduced resistance to infection by PstDC3000. Our conclusion is that ATP-dependent binding cassette transporter G family member16 is involved in ABA tolerance and contributes to plant resistance against PstDC3000. This is one of the first examples, to our knowledge, of ATP-dependent binding cassette transporter involvement in plant resistance to infection by a bacterial pathogen. It also suggests a possible mechanism by which plants reduce the deleterious effects of ABA hijacking during pathogen attack. Collectively, these results improve our understanding of basal resistance in Arabidopsis and offer unique ABA-related targets for improving the innate resistance of plants to bacterial infection.
The impact of social responsibility disclosure and governance on financial analysts’ information environment
Authors: Cormier Denis , Magnan Michel 
Published: August 2014

Purpose– The purpose of this paper is to explore the relationships between corporate social responsibility (CSR) disclosure, corporate governance and financial analysts’ information environment, as proxied by their ability to forecast a firm’s earnings. Hence, we extend prior voluntary disclosure research.Design/methodology/approach– Our paper considers that the determination of CSR disclosure, corporate governance and financial analyst forecasting work are closely intertwined. Therefore, we rely on simultaneous equations to explore these relations.Findings– Findings show that there is a direct relation between both CSR disclosure and corporate governance and financial analysts’ information environment: more disclosure and better governance translate into a tighter consensus in earnings forecasts as well as less dispersion. However, corporate governance substitutes for CSR disclosure in improving analyst forecast precision, thus supporting a comprehensive view of corporate governance that encompasses disclosure. Finally, results also suggest that CSR disclosure, through its effect on governance and analyst following, has an indirect influence on analyst forecast precision. Overall, it appears that both CSR disclosure and good corporate governance attract analysts and improve their ability to forecast earnings.Originality/value– To the best of our knowledge, our study is the first to investigate the joint effect of corporate governance and CSR disclosure on analyst forecast precision.
Corporate governance, analyst following and firm value
Authors: Mouselli Sulaiman , Hussainey Khaled 
Published: August 2014

Purpose
– The purpose of this paper is to examine the impact of a firm’s corporate governance (CG) mechanisms on the number of financial analysts following UK firms. The potential effect of the number of analysts following firms in the UK on the association between CG mechanisms and firm value was also examined.

Design/methodology/approach
– Multiple regression models were used to examine the association between CG, analyst coverage and firm value for a large sample of UK firms listed in London Stock Exchange with financial year ends between January 2003 and December 2008.

Findings
– It was found that the aggregate level of CG quality is positively associated with the number of analysts following UK firms. In addition, the compensation score is the main component that affects the number of analysts following UK firms. The results suggest that financial analysts are particularly concerned with how much compensation executives and directors receive. This is consistent with Jensen and Meckling (1976) who argue that chief executive officer (CEO) compensation can be used as effective mechanisms for mitigating agency costs. Hence, higher levels of CEO compensation attract more financial analysts to follow the firm. Surprisingly, when the joint effect of both CG quality and the number of analysts following on firm value was examined, no significant effect was found for both variables on firm value.

Originality/value
– This paper contributes to prior research by providing the first empirical evidence on the impact of disaggregated levels of CG on analyst following and firm value for a large sample of UK firms.
Board effectiveness in corporate crises: lessons from the evolving empirical research
Authors: Abatecola Gianpaolo , Farina Vincenzo , Gordini Niccolò 
Published: August 2014

Purpose
– This article aims to comment on how the empirical research on board effectiveness in crisis contexts has been evolving over time. Over the years, the empirical evidences have demonstrated that particular board features can improve the survival chances of firms suffering a crisis and, to date, experts agree that discussing these evidences is necessary for the further improvement of knowledge in this field.

Design/methodology/approach
– This is a critical review article.

Findings
– Valuable evidences emerge from the review. For example, it seems that board independence has a key role in enhancing the performance of firms suffering a crisis. At the same time, the review suggests that further refinement is needed for supporting (or eventually refuting) the idea that boards and/or Chief Executive Officers (1) must be replaced to achieve successful turnaround strategies.

Originality/value
– On the basis of its findings, the review also prospects a number of conceptual and methodological implications for the future research and practice about board effectiveness in corporate crises. For example, these implications are associated with future investigations about the executives’ sociodemographic features and personality traits as well. More international comparisons seem also needed to improve the reliability of the extant knowledge.
Good governance and confidentiality: a matter of the preservation of the public sphere
Authors: Goede Miguel , J. Neuwirth Rostam 
Published: August 2014

Purpose
– The purpose of this article is to discuss the concepts confidentiality and transparency in the context of good governance.

Design/methodology/approach
– After exploring the concepts of confidentiality, good governance and other relevant concepts, they are related to each other.

Findings
– When it comes to good governance, transparency is overrated and confidentiality is taken for granted. For good governance, there must be a balance between the two to preserve the public sphere.

Originality/value
– The paper contributes to the understanding of good governance and the evolution of the public sphere.
Corporate governance model of a state-owned enterprise: evidence from an Asian emerging market
Authors: Yaacob Hisham , Basiuni Jefri 
Published: August 2014

Purpose
– The purpose of this study is to examine a state-owned enterprise corporate governance model in an Asian emerging market. Corporate governance has attracted much attention and is still a hot topic among shareholders, directors and company regulators. Failure of large corporations in the past decades not only affected the shareholders and investors, rather it adversely affects all the stakeholders. Good corporate governance practices are argued to curb company’s failures due to fraudulent activities, collusion schemes and mismanagement.

Design/methodology/approach
– The study took the qualitative approach. It utilized case study method. The company is designated as Company R, as the study is not allowed to reveal the company’s real name.

Findings
– The study found that the corporate governance structure of the board is of unitary or one-tier board, which is common in the Anglo-American settings. The board members are selected and appointed by the government. They are chosen from highly capable and trustworthy government officers to represent and safeguard the government’s interest in the company. As for the ownership structure, it is a typical company with the other Asian state-owned enterprises where the state has full ownership and control of the company.

Originality/value
– The study fills the gap in the corporate governance model literature, especially in the context of Asian emerging economies’ state-owned companies. Furthermore, the authors believe that this study is among the first to examine the corporate governance model in this country. It shed lights on the corporate governance model in terms of governance structure, the ownership and shareholders’ right, roles of the board, regulatory framework and control mechanism and, finally, disclosure and transparency.
Student response to e-books: study of attitude toward reading among elementary school children in Kuwait
Authors: Sattar Chaudhry Abdus 
Published: August 2014

Purpose
– The paper aims to investigate the impact of e-books on attitude towards reading among elementary school students. The paper also reflects on issues related to readings and e-books.

Design/methodology/approach
– Experimental method of research was used to carry out the study. Experiment was conducted on fourth-grade students in an international school in Kuwait. The control group consisted of nine students. The experimental group had 16 students: eight read the book under the “read-to-me” feature and the other half read the book alone. Students in the two groups were assigned readings randomly and their reactions were studied and compared using different methods.

Findings
– The experiment demonstrated that students enjoyed reading the electronic medium more than the paperback alternative. The difference, however, was not significant. In addition, difference between the comprehension levels of the three conditions was also insignificant. Students did, however, finish reading the paperback book in a significantly shorter time.

Research limitations/implications
– A pilot study would have been desirable and also the number of questions asked in the comprehension test could have been expanded. The authors were also not able to explore the possibility of using an automated tool to record the reading time. The two reading instruments used (iPads and iPods) might have affected the students’ understanding and enjoyment of the book, although no noticeable differences were found.

Practical implications
– The experiment indicted that one of the apparent benefits of reading the e-book was its built-in picture dictionary, as the book used in the study incorporated a lot of word coinage in his texts. Lessons learnt from the study can benefit in enhancing features of e-books and designing reading programmes to help build more positive attitude towards reading among children.

Originality/value
– Little research has been reported in the literature on investigation of e-books towards reading attitude particularly using empirical studies or experimental research. Most literature focuses on availability of e-books and their features. This study makes a good contribution to the literature on this important aspect of research and makes available useful practical information as well.
Usage patterns and perception toward e-books: experiences from academic libraries in South Korea
Authors: Hwang Jae-Young , Kim Jayhoon , Lee Boram , Hwan Kim Jeong 
Published: August 2014

Purpose
– This study aims to investigate and analyze the usage patterns of electronic book (e-book) users and their perceptions of e-books from various perspectives. Recently, e-book usage and subscriptions at university libraries in South Korea have significantly increased.

Design/methodology/approach
– The authors conduct an extensive survey of 959 e-book users at the five major university libraries, which subscribe to the most e-books in South Korea. The survey contains structured questions as well as fields for open commentary to acquire various opinions. The authors also apply diverse analysis techniques, depending on the characteristics of the survey questions.

Findings
– Since the early 2000s, when e-books were first introduced, there has been a considerable change in perception and increase in usage of e-books at South Korean university libraries. Despite this progress, most functions of e-books are not fully utilized. The authors find the role of the library to be very important, as most users learn about and access e-books through the Web sites of university libraries, not through such portal sites as Google. The remarkable result is that users with higher education more easily recognize and have better experiences with e-book services.

Originality/value
– This study draws extensive samples and objective questions compared to previous research. The authors also contrast our research results with the other studies conducted within and outside of South Korea. The research shows the changes and differences in perception and usage of e-books by period and country. More importantly, the authors suggest strategies to boost e-book use based on user demands.
Road-mapping the business potential of sustainability within the European manufacturing industry
Authors: Valkokari Katri , Valkokari Pasi , Palomäki Katariina , Uusitalo Teuvo , Reunanen Markku , Macchi Marco , Rana Padmakshi , Prasanna Liyanage Jayantha 
Published: August 2014

Purpose
– The purpose of this study is to explore the required changes, outline business potential and envisage the key steps that a networked manufacturing industry needs to take to reach more sustainably performing manufacturing in the future.

Design/methodology/approach
– The paper utilises a visionary road-mapping approach to study the required changes and the business potential related to sustainable development in the manufacturing industry.

Findings
– The results were summarised in three sub-roadmaps empowerment of stakeholders, increase efficiency and creation of new performance criteria. On the basis of the summary of the sub-roadmaps, the framework was configured to describe the opportunities and challenges of sustainable business development in the European manufacturing industry.

Research limitations/implications
– A clear implication of this study is that a more system-oriented approach, new models for collaboration between network actors and transparently shared network-level KPIs are required before further steps towards a sustainable manufacturing industry can be taken. In addition, sustainability-driven business models are required to specify these changes concretely.

Practical implications
– The presented sub-roadmaps and framework summarising them could provide new insights to business practitioners exploring business potential of sustainability.

Social implications
– Understanding about the road-mapping process as tool that enables interaction and envisioning between different stakeholders could also have social implications supporting shared industry-level learning processes.

Originality/value
– Studies of sustainability within the manufacturing industry have focused mainly on green issues in supply-chain management or corporation-level governance models and reporting practices. The paper presents a broader view of sustainable development and recognises networked business as part of the solution.
The value of sociality
Authors: Lukinova Evgeniya , Myagkov Mikhail , Shishkin Pavel 
Published: August 2014

Purpose– This paper aims to study the value of sociality. Recent experimental evidence has brought to light that the assumptions of the Prospect Theory by Kahneman and Tversky do not hold in the proposed substantive domain of “sociality”. In particular, the desire to be a part of the social environment, i.e. the environment where individuals make decisions among their peers, is not contingent on the framing. Evolutionary psychologists suggest that humans are “social animals” for adaptive reasons. However, entering a social relationship is inherently risky. Therefore, it is extremely important to know how much people value “sociality”, when the social outcomes are valued more than material outcomes and what kinds of adaptations people use.Design/methodology/approach– We develop a new theory and propose the general utility function that features “sociality” component. We test the theory in the laboratory experiments carried out in several countries.Findings– Our results suggest that when stakes are low the theory of “sociality” is successful in predicting individual decisions: on average, people do value “sociality” and it surpasses the monetary loss.Originality/value– The main contribution of this paper is the breakdown of the risk attitudes under low stakes and individual level of decision-making. Another advancement is the ability to formalize the social utility or the theory of “sociality” in an economic model; we use general utility function that we define both on the outcomes and on the process of the decision-making itself and test in laboratory studies.
Interactive foresight on the Hungarian SMEs
Authors: Hideg Eva , Nováky Erzsébet , Alács Péter 
Published: August 2014

Purpose– The aim of this study is to present a concept of interactive foresight process, its theoretical and methodological considerations and a foresight exercise concerning the development of knowledge economy in the Central Hungarian Region.Design/methodology/approach– A methodology of interactive foresight process for creating regional future concepts is developed, which is based on a specific meaning of integral futures and uses online solutions, too.Findings– Personal meetings with small and medium enterprise (SME) stakeholders and the works of interactive communications with feedbacks within and among stakeholder groups was organized around the research homepage. The networking created the interconnection and the feedbacks between the stakeholders and the futurist group in the process of shaping regional future ideas. The online networking is running.Research limitations/implications– The low number of stakeholders can limit the validity and acceptance of futures ideas created by this process.Practical implications– The developed interactive foresight process can also be applicable at different organizational levels and in different fields for shaping shared future ideas.Social implications– Application of interactive foresight process can contribute to the development of anticipatory democracy.Originality/value– A theoretically based interactive foresight process has been developed in which stakeholders can participate not only interactively in the foresight process but they can implement the achievements in their enterprising activity as well. The participants were interested in foresight and cooperative during the whole process because they learned the use of foresight tools through collective solution of practical tasks which were important for them.