bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Regio‐ and Enantioselective Catalytic Monoepoxidation of Conjugated Dienes: Synthesis of Chiral Allylic cis‐Epoxides.
Authors: Jat Jawahar L. , De Saroj Ranjan , Kumar Ganesh , Adebesin Adeniyi Michael , Gandham Shyam K. , Falck John R. 
Published: June 2015

AbstractA new catalyst Ti(IV)‐salan system efficiently promotes the diastereo‐ and enantioselective monoepoxidation of conjugated dienes using H2O2 even in the presence of other olefins and adjacent stereocenters.
ChemInform Abstract: Regio‐ and Stereoselective Pd‐Catalyzed Direct Arylation of Unactivated sp3C(3)—H Bonds of Tetrahydrofuran and 1,4‐Benzodioxane Systems.
Authors: Parella Ramarao , Babu Srinivasarao Arulananda 
Published: June 2015

AbstractThe Pd‐catalyzed, direct arylation of tetrahydrofuran and benzodioxane quinoline‐carboxamides with aryl iodides at the C‐3 position is reported.
ChemInform Abstract: A Green, Catalyst‐Free, Solvent‐Free, High Yielding One Step Synthesis of Functionalized Benzo[f]furo[3,2‐c]chromen‐4‐(5H)‐ones and Furo[3,2‐c]quinolin‐4‐(5H)‐ones.
Authors: Kumar Manoj , Kaur Tanpreet , Gupta Vinod K. , Sharma Anuj 
Published: June 2015

Abstract17 Benzo[f]furo[3,2‐c]chromen‐4‐(5H)‐ones of type (IV) and 12 furo[3,2‐c]quinolin‐4‐(5H)‐ones of type (VII) are prepared.
ChemInform Abstract: Diastereoselective Synthesis of 2,6‐Diaryltetrahydrothiopyran‐4‐ones by Phase‐Transfer Catalysis.
Authors: Gendron Thibault , Kessedjian Hripsimee , Davioud‐Charvet Elisabeth , Lanfranchi Don Antoine 
Published: June 2015

AbstractTwo efficient phase‐transfer‐catalyzed protocols for the diastereoselective synthesis of cis and trans isomers of 2,6‐diaryltetrahydrothiopyran‐4‐ones (2,6‐DATHTPs) are developed.
ChemInform Abstract: BF3/Nano‐Sawdust as a Green, Biodegradable and Inexpensive Catalyst for the Synthesis of Highly Substituted Dihydro‐2‐oxopyrroles.
Authors: Mirjalili Bi Bi Fatemeh , Zare Reshquiyea Reza 
Published: June 2015

AbstractBF3/nano‐sawdust is a heterogeneous solid acid catalyst for the one‐pot cascade synthesis of highly functionalized dihydro‐2‐oxypyrroles via four‐component reactions of various primary amines and aldehydes and dialkylacetylenedicarboxylates under thermal conditions.
ChemInform Abstract: Reversible C—C Bond Activation Enables Stereocontrol in Rh‐Catalyzed Carbonylative Cycloadditions of Aminocyclopropanes.
Authors: Shaw Megan H. , McCreanor Niall G. , Whittingham William G. , Bower John F. 
Published: June 2015

AbstractIn the presence of a cationic Rh(I)‐catalyst, amino‐substituted cyclopropanes undergo carbonylative cycloaddition with tethered alkenes affording stereochemically complex N‐heterocyclic scaffolds.
ChemInform Abstract: A Metal‐Free Synthesis of Oxindoles by a Radical Addition‐Cyclization onto N‐Arylacrylamides with Xanthates.
Authors: Wang Shucheng , Huang Xuhu , Li Bowen , Ge Zemei , Wang Xin , Li Runtao 
Published: June 2015

AbstractVarious arylalkylation products including alkyl ester‐, benzyl‐, cyano‐, ketone‐, amine‐, and amide‐ substituted oxindoles are conveniently obtained.
ChemInform Abstract: A Highly Diastereoselective Friedel—Crafts Reaction of Indoles with Isatin‐Derived N‐Sulfinyl Ketimines Towards the Efficient Synthesis of Chiral Tetrasubstituted 3‐Indolyl‐3‐aminooxindoles.
Authors: Chen Jian‐Ping , Chen Wen‐Wen , Li Yi , Xu Ming‐Hua 
Published: June 2015

AbstractThis method can be extended to dihydroindole (IX) and pyrrole (XI) as coupling partner.
ChemInform Abstract: Synthesis of 4‐Hydroxyindole Fused Isocoumarin Derivatives and Their Fluorescence “Turn‐off” Sensing of Cu(II) and Fe(III) Ions.
Authors: Pathak Sudipta , Das Doyel , Kundu Ashis , Maity Subhendu , Guchhait Nikhil , Pramanik Animesh 
Published: June 2015

AbstractTitle compounds are prepared by an acid‐catalyzed intramolecular rearrangement and subsequent dehydrogenation.
ChemInform Abstract: An Efficient Transition‐Metal‐Free Synthesis of 1H‐Indazoles from Arylhydrazones with Montmorillonite K‐10 under O2 Atmosphere.
Authors: Yu Jin , Lim Jin Woo , Kim Su Yeon , Kim Jimin , Kim Jae Nyoung 
Published: June 2015

AbstractAn efficient synthesis of 1H‐indazoles from arylhydrazones in the presence of montmorillonite K‐10 is reported.
ChemInform Abstract: A Cascade Synthesis of Aminohydantoins Using in situ‐Generated N‐Substituted Isocyanates.
Authors: Vincent‐Rocan Jean‐Francois , Clavette Christian , Leckett Kyle , Beauchemin Andre M. 
Published: June 2015

AbstractSimple hydrazides and hydrazones are used as precursors of the required N‐substituted isocyanates.
ChemInform Abstract: Copper‐Mediated Formally Dehydrative Biaryl Coupling of Azine N‐Oxides and Oxazoles.
Authors: Odani Riko , Hirano Koji , Satoh Tetsuya , Miura Masahiro 
Published: June 2015

AbstractThe title reaction proceeds without the use of noble transition metals such as palladium and rhodium, which are normally promotors in the related dehydrogenative couplings with azine N‐oxides.
ChemInform Abstract: Intermolecular Coupling of 2‐Iodoanilides with Benzoxazoles: Synthesis of N‐(2‐Benzoxazol‐2‐ylphenyl)benzamides via C—H Activation.
Authors: Sasmal Swarnendu , Sen Indira , Hall Roger G. , Pal Sitaram 
Published: June 2015

AbstractOptimized conditions to favor the intermolecular metal‐catalyzed transformation over the intramolecular ring closure of 2‐iodoanilides are presented.
ChemInform Abstract: Elemental Sulfur Mediated Decarboxylative Redox Cyclization Reaction of o‐Chloronitroarenes and Arylacetic Acids.
Authors: Guntreddi Tirumaleswararao , Vanjari Rajeshwer , Singh Krishna Nand 
Published: June 2015

Abstract2‐substituted benzothiazoles are prepared by the title reaction under metal‐, oxidant‐, and solvent‐free condition.
ChemInform Abstract: Bifunctional Amino Sulfonohydrazide Catalyzed Direct Asymmetric Mannich Reaction of Cyclic Ketimines with Ketones: Highly Diastereo‐ and Enantioselective Construction of Quaternary Carbon Stereocenters.
Authors: Zhang Sheng , Li Lijun , Hu Yanbin , Zha Zhenggen , Wang Zhiyong , Loh Teck‐Peng 
Published: June 2015

AbstractA bifunctional amino sulfonohydrazide is shown to enhance reactivity and enantioselectivity in the direct asymmetric Mannich reaction of N‐sulfonyl cyclic ketimines with ketones.
ChemInform Abstract: One‐Pot Three‐Component Synthesis of 1,4,5‐Trisubstituted 5‐Iodo‐1,2,3‐triazoles from 1‐Copper(I) Alkyne, Azide and Molecular Iodine.
Authors: Zhang Jianlan , Chen Wenwen , Wang Bo , Zhao Zhouxing , Wang Xinyan , Hu Yuefei 
Published: June 2015

AbstractCompared with the method with the ligand Et3N, the ligand free procedure gives the higher yields, but a longer reaction time is required.
ChemInform Abstract: Regioselective Palladium‐Catalyzed Decarboxylative Cross‐Coupling Reaction of Alkenyl Acids with Coumarins: Synthesis of 3‐Styrylcoumarin Compounds.
Authors: Wang Xu , Li Shen‐yan , Pan Ying‐ming , Wang Heng‐shan , Chen Zhen‐feng , Huang Ke‐bin 
Published: June 2015

AbstractA novel and efficient protocol for the regioselective synthesis of 3‐styrylcoumarins from readily available cinnamic acids and coumarins is presented.
ChemInform Abstract: Synthesis of Allylated Quinolines/Isoquinolines via Palladium‐Catalyzed Cyclization—Allylation of Azides and Allyl Methyl Carbonate.
Authors: Luo Jiang , Huo Zhibao , Fu Jun , Jin Fangming , Yamamoto Yoshinori 
Published: June 2015

AbstractA novel one‐step synthesis of allylated quinolines and isoquinolines is achieved by Pd‐catalyzed reaction of aryl or benzyl azides bearing an ortho‐alkynyl substituent with allyl methyl carbonate as optimized reagent.
ChemInform Abstract: Synthesis of Enantioenriched 5,6‐Dihydrophenanthridine Derivatives Through retro‐Carbopalladation of Chiral o‐Bromobenzylamines.
Authors: Ye Juntao , Limouni Aurore , Zaichuk Sonia , Lautens Mark 
Published: June 2015

AbstractNovel synthetic approach for the rapid generation of biologically important 5,6‐dihydrophenanthridine skeletons is developed.
ChemInform Abstract: Intramolecular Heterocyclization of O‐Propargylated Aromatic Hydroxyaldehydes as an Expedient Route to Substituted Chromenopyridines under Metal‐Free Conditions.
Authors: Keskin Selbi , Balci Metin 
Published: June 2015

AbstractChromenopyridines are prepared regioselectively in two steps by O—propargylation of aromatic hydroxyaldehydes followed by intramolecular heterocyclization with propargylamine.
ChemInform Abstract: Synthesis of 6‐Amino‐ and 6‐Hydroxy‐1‐aryl‐2‐(thiazol‐2‐yl)‐9‐ (2‐thienoyl)‐1,2‐dihydro‐3H‐pyrrolo[3,4‐b]quinolin‐3‐ones.
Authors: Gein V. L. , Mar'yasov M. A. , Gein L. F. 
Published: June 2015

AbstractFor example, by using 3‐methoxyaniline, the corresponding 3‐amino derivative of pyrrolinone (V) is obtained.
ChemInform Abstract: From Nitrobenzenes to Substituted Tetrahydroquinolines in a Single Step by a Domino Reduction/Imine Formation/Aza‐Diels—Alder Reaction.
Authors: Imrich Hans‐Georg , Conrad Juergen , Bubrin Denis , Beifuss Uwe 
Published: June 2015

AbstractTetrahydro(cyclopenta)quinolines are synthesized by combining the reduction of nitroanilines with a Povarov reaction in a three‐component one‐pot approach.
ChemInform Abstract: Copper‐Catalyzed Oxidative Amination of sp3 C—H Bonds under Air: Synthesis of 1,3‐Diarylated Imidazo[1,5‐a]pyridines.
Authors: Wang Huiqiao , Xu Wentao , Wang Zhiqiang , Yu Lintao , Xu Kun 
Published: June 2015

AbstractAn efficient Cu(II)‐catalyzed oxidative amination of sp3 C—H bonds using air as the terminal oxidant is presented.
ChemInform Abstract: Reaction of Pyridoxal with Phenols: Synthesis of Novel 1‐Aryl‐Substituted Furopyridines.
Authors: Kibardina Ludmila K. , Chumakova Ludmila V. , Gazizov Almir S. , Burilov Alexander R. , Pudovik Michail A. 
Published: June 2015

AbstractThe new method is based on the acid‐catalyzed reaction of pyridoxal with polyfunctional phenols for the synthesis of potentially biologically active furopyridine derivatives.
ChemInform Abstract: Electron‐Withdrawing Group Effect in Aryl Group of Allyl Bromides for the Successful Synthesis of Indolizines via a Novel [3 + 3] Annulation Approach.
Authors: Park Sujin , Kim Ikyon 
Published: June 2015

AbstractElectron‐withdrawing substituted aryl groups on the allyl bromide facilitate the cyclization process.
ChemInform Abstract: Synthesis and Mechanism of Novel Fluorescent Coumarin—Dihydropyrimidinone Dyads Obtained by the Biginelli Multicomponent Reaction.
Authors: Vitorio Felipe , Pereira Thiago Moreira , Castro Rosane Nora , Guedes Guilherme Pereira , Graebin Cedric Stephan , Kuemmerle Arthur Eugen 
Published: June 2015

AbstractA series of 3,4‐dihydropyrimidin‐2(1H)‐one/thione (IV), (VI), (VIII) with high UV absorption and blue fluorescent properties are synthesized from synthetic coumarin β‐ketoester derivatives.
ChemInform Abstract: The Development of Carbon—Carbon Bond Forming Reactions of Aminal Radicals.
Authors: Schiedler David A. , Vellucci Jessica K. , Lu Yi , Beaudry Christopher M. 
Published: June 2015

AbstractThe generation of aminal radicals using AIBN and a hydrogen donor and their subsequent transformation in a range of carbon‐carbon bond formation reactions based on electron deficient alkene is extensively elaborated.
ChemInform Abstract: Pyrazoloquinazolinones and Pyrazolopyridopyrimidinones by a Sequential N‐Acylation—SNAr Reaction.
Authors: Gnanasekaran Krishna Kumar , Muddala N. Prasad , Bunce Richard A. 
Published: June 2015

AbstractAn efficient synthesis of pyrazolo[1,5‐a]quinazolin‐5(4H)‐ones and pyrazolo[1,5‐a]‐pyrido[3,2‐e]pyrimidin‐5(4H)‐ones using a sequential acylation‐SNAr reaction is developed.
ChemInform Abstract: Tetra‐Butylphosphonium Arginine‐Based Ionic Liquid‐Promoted Cyclization of 2‐Aminobenzonitrile with Carbon Dioxide.
Authors: Lang Xian‐Dong , Zhang Shuai , Song Qing‐Wen , He Liang‐Nian 
Published: June 2015

AbstractBu4P[Arg] is an efficient, stable, and recyclable catalyst for the synthesis of quinazoline‐2,4(1H,3H)‐diones (III) from various 2‐aminobenzonitriles (I) and CO2 under solvent‐free reaction conditions.
ChemInform Abstract: Solvent‐Free Sonochemical Multi‐Component Synthesis of Benzopyranopyrimidines Catalyzed by Polystyrene Supported P‐Toluenesulfonic Acid.
Authors: Thirupathaiah Bodakuntla , Reddy Mudumala Veeranarayana , Jeong Yeon Tae 
Published: June 2015

AbstractThe title compounds are efficiently and environmentally friendly obtained by ultrasound‐mediated condensation of salicylic aldehydes, malononitrile, and secondary amines under solvent‐free conditions.
ChemInform Abstract: Preparation of Tri‐ and Tetrasubstituted Allenes via Regioselective Lateral Metalation of Benzylic (Trimethylsilyl)alkynes Using TMPZnCl·LiCl.
Authors: Quinio Pauline , Francois Cyril , Escribano Cuesta Ana , Steib Andreas K. , Achrainer Florian , Zipse Hendrik , Karaghiosoff Konstantin , Knochel Paul 
Published: June 2015

AbstractZincation of various trimethylsilyl propynes with TMPZnCl·LiCl followed by a Pd‐catalyzed coupling with aryl halides provides arylated allenes in high yields.
ChemInform Abstract: Reductive Arene ortho‐Silanolization of Aromatic Esters with Hydridosilyl Acetals.
Authors: Hua Yuanda , Asgari Parham , Dakarapu Udaya Sree , Jeon Junha 
Published: June 2015

AbstractThe reaction proceeds via cyclic silyl acetal intermediates that can be obtained as major products in the case of ortho‐substituted aryl esters (XII).
ChemInform Abstract: Alkenylation of Phosphacoumarins via Aerobic Oxidative Heck Reactions and Their Synthetic Application to Fluorescent Benzophosphacoumarins.
Authors: Kim Cheol‐Eui , Son Jeong‐Yu , Shin Seohyun , Seo Boram , Lee Phil Ho 
Published: June 2015

AbstractA variety of activated as well as nonactivated alkenes react with the title compounds via aerobic oxidative Heck reactions to 3‐alkenylphosphacoumarins.
ChemInform Abstract: Silver‐Mediated Direct Phosphorylation of Benzothiazoles and Thiazoles with Diarylphosphine Oxides.
Authors: Zhang Hui‐Jun , Lin Weidong , Wu Zhengjian , Ruan Wenqing , Wen Ting‐Bin 
Published: June 2015

AbstractThe convenient, efficient protocol for the phosphorylation of the title compounds furnishes 2‐diarylphosphoryl‐substituted products under mild conditions.
ChemInform Abstract: Selective Deprotection of Benzyl (Bn) Ethers in the Presence of para‐Methoxybenzyl (PMB) Ethers.
Authors: Li Xiaohua , Saleh Zachary , Egri Brian , Hourani Ali , Harding Luke , Baryal Kedar N. , Zhu Jianglong 
Published: June 2015

AbstractAn efficient method for chemoselective deprotection of benzyl ethers in the presence of 4‐methoxybenzyl ethers using radical anion reductant lithium 4,40‐di‐tert‐butylbiphenyl is developed.
ChemInform Abstract: An Expeditious Route to Both Enantiomers of All Carbon Quaternary Stereocenters at C‐3 Carbon of Lactams via [3,3]‐Sigmatropic Rearrangement: Total Synthesis of (—)‐Physostigmine.
Authors: Pandey Ganesh , Khamrai Jagadish , Mishra Akash 
Published: June 2015

AbstractThe title compound (IV) is obtained in 11 linear steps and 4.5% overall yield via Johnson—Claisen rearrangement from γ—lactam.
ChemInform Abstract: Building Polyfunctional Piperidines: A Stereoselective Strategy of a Three‐Component Mannich Reaction Inspired by Biosynthesis and Applications in the Synthesis of Natural Alkaloids (+)‐241D; (‐)‐241D; Isosolenopsin A and (‐)‐Epimyrtine.
Authors: Yang Yang 
Published: June 2015

AbstractA general method to synthesize multisubstituted chiral piperidines is developed using a stereoselective three‐component vinylogous Mannich‐type reaction.
ChemInform Abstract: Three New Oxylipins from an Okinawan Marine Sponge Plakortis sp.
Authors: Tanaka Naonobu , Asai Miki , Kusama Taishi , Fromont Jane , Kobayashi Jun'ichi 
Published: June 2015

Abstractisolation and structure elucidation of oxylipins manzamenone P (I), 6′‐O‐methylmanzamenone K (IIa), and 6′‐O‐ethylmanzamenone K (IIb)
ChemInform Abstract: The Quest for an Oxidative Coupling of Phenols and Indoles Towards Benzofuroindolines: A Two‐Stage Approach
Authors: Beaud Rodolphe , Tomakinian Terry , Denizot Natacha , Pouilhes Annie , Kouklovsky Cyrille , Vincent Guillaume 
Published: June 2015

AbstractReview: [14 refs.
ChemInform Abstract: Rechargeable Magnesium Battery: Current Status and Key Challenges for the Future
Authors: Saha Partha , Datta Moni Kanchan , Velikokhatnyi Oleg I. , Manivannan Ayyakkannu , Alman David , Kumta Prashant N. 
Published: June 2015

AbstractReview: 239 refs.
ChemInform Abstract: Saturation Vapor Pressures and Transition Enthalpies of Low‐Volatility Organic Molecules of Atmospheric Relevance: From Dicarboxylic Acids to Complex Mixtures
Authors: Bilde Merete , Barsanti Kelley , Booth Murray , Cappa Christopher D. , Donahue Neil M. , Emanuelsson Eva U. , McFiggans Gordon , Krieger Ulrich K. , Marcolli Claudia , Topping David , et al.  
Published: June 2015

AbstractReview: 257 refs.
Methan‐Monooxygenase‐Aktionszentrum Q
Authors: Jaenicke Lothar 
Published: June 2015

AbstractIn Erdölformationen und Tonschiefern eingeschlossen, unter dem Tiefseeschlamm unter hohem Druck aggregiert, lagern immense Mengen des Treibhausgases Methan, auf die die energiehungrige Menschheit beutegierige Augen geworfen hat, sie unbarmherzig mit allen Mitteln herbeizufördern und zu verbrauchen. Bislang wird Methan nur als nutzlos‐eindrucksvolles Fanal technischer Impotenz “abgefackelt”, im intelligenteren Fall die höchst energiereiche C‐H‐Bindung von CH4 (105 kcal mol–1, das Maximum aller organischen Bindungen) im energie‐ und investitionsaufwendigen Hochtemperatur‐Hochdruck‐Verfahren nach Fischer‐Tropsch zu Methanol oxidiert und zu längerkettigen Kohlenwasserstoffen verarbeitet. Die Natur macht vor, dass es auch anders geht.
Racial differences in breast cancer survival in a large urban integrated health system
Authors: Roseland Molly E. , Pressler Mary E. , E. Lamerato Lois , Krajenta Rick , Ruterbusch Julie J. , Booza Jason C. , Schwartz Kendra , Simon Michael S. 
Published: June 2015

BACKGROUNDAfrican American (AA) women are known to have poorer breast cancer survival than whites, and the differences may be related to underlying disparities in their clinical presentation or access to care. This study evaluated the relationship between demographic, treatment, and socioeconomic factors and breast cancer survival among women in southeast Michigan.METHODSThe population included 2387 women (34% AA) with American Joint Committee on Cancer stage I to III breast cancer who were treated at the Henry Ford Health System (HFHS) from 1996 through 2005. Linked data sets from the HFHS, the Metropolitan Detroit Cancer Surveillance System, and the US Census Bureau were used to obtain demographic and clinical information. Comorbidities were classified with the modified Charlson comorbidity index (CCI). Economic deprivation was categorized with a census tract–based deprivation index (DI), which was stratified into 5 quintiles of increasing socioeconomic disadvantage.RESULTSCompared with whites, AA women were significantly more likely to have larger, hormone receptor–negative tumors and more comorbidities and to reside in an economically deprived area. In an unadjusted analysis, AAs had a significantly higher risk of death (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.16‐1.59); however, after adjustments for clinical (age, stage, hormone receptor, and CCI) and societal factors (DI), the effect of race was not significant (HR, 1.13 [95% CI, 0.96–1.34] , and HR, 0.97 [0.80–1.19] respectively).CONCLUSIONSRacial differences in breast cancer survival can be explained by clinical and socioeconomic factors. Nonetheless, AA women with breast cancer remain disproportionately affected by unfavorable tumor characteristics and economic deprivation, which likely contribute to their increased overall mortality. Cancer 2015;121:3668–3675. © 2015 American Cancer Society.
Effect of six years intensified multifactorial treatment on levels of hs‐CRP and adiponectin in patients with screen detected type 2 diabetes: The ADDITION‐Netherlands randomized trial
Authors: den Ouden Henk , Berends Jacqueline , Stellato Rebecca K. , Beulens Joline W. , Rutten Guy E. H. M. 
Published: June 2015

AbstractBackgroundLevels of high‐sensitivity C‐reactive protein (hs‐CRP) and adiponectin, reflecting chronic inflammation, are associated with cardiovascular disease in type 2 diabetes. The long‐term effects of multifactorial therapy in type 2 diabetes patients on CRP and adiponectin are unknown.MethodsThe ADDITION‐NL study is a randomized clinical trial among screen‐detected type 2 diabetes patients, randomized to intensive treatment (HbA1c <7.0% (53 mmol/mol), blood pressure ≤135/85 mmHg, total cholesterol ≤3.5 mmol/L) or routine care. Hs‐CRP and adiponectin were measured before and 1, 2 and 6 years after inclusion. We analysed the effectiveness of the intervention on hs‐CRP and adiponectin levels using a mixed effects model, taking into account practice, baseline levels and different medications.ResultsA total of 424 patients were included (intensive care n = 235; routine care n = 189). Both groups were well matched. Body mass index, systolic blood pressure, total cholesterol and HbA1c improved significantly more in the intensive care group compared to routine care group. Levels of hs‐CRP decreased significantly in both treatment groups over time. Mean hs‐CRP in the routine care group was 24% higher (p = 0.0027) than in the intensive treatment group during follow‐up. After an initial increase the adiponectin values levelled off to nearly baseline values in both groups. The difference between the two groups after 6 years was 0.44 µg/mL (p = 0.27).ConclusionsIntensified multifactorial treatment in type 2 diabetes results in an enhanced decrease in hs‐CRP. Whether this is clinically meaningful remains uncertain. The link to adiponectin seems to be more complex. Copyright © 2015 John Wiley & Sons, Ltd.
Enantioselective Synthesis of Four Natural Homoisoflavonoids
Authors: Yu Yan‐Chao , Zhu Shijun , Lu Xiao‐Wei , Wu Yikang , Liu Bo 
Published: June 2015

AbstractFour naturally occurring sappanin‐type homoisoflavonoids were synthesized in optically active form with the stereogenic centers of predefined absolute configuration constructed by using Evans' asymmetric aldol reaction. Analysis of the synthesized compounds not only confirmed the previously assigned planar structures but also was used to determine the absolute configurations of the natural products. Errors in previously reported NMR signals/solvents are also revealed.
Synthesis and Isolation of Enantiomerically Enriched Cyclopenta[b]benzofurans Based on Products from Anodic Oxidation of 2,4‐Dimethylphenol
Authors: Mirion Michael , Andernach Lars , Stobe Caroline , Barjau Joaquin , Schollmeyer Dieter , Opatz Till , Lützen Arne , Waldvogel Siegfried R. 
Published: June 2015

AbstractThe anodic treatment of 2,4‐dimethylphenol offers a powerful and direct method for the construction of a dehydrotetramer with four contiguous stereocentres on a multigram scale. The installation of propellanes on this scaffold using enantiomerically pure carbonyl compounds leads to a mixture of diastereomers. This mixture is easily separable using standard chromatography and gives rise to optically pure cyclopenta[b]benzofurans which are important scaffolds in a variety of natural products. The synthesis is easy to perform and allows a reliable access to chiral compounds with very high enantiomeric excess. It was possible to determine the absolute configuration of these compounds by comparison of experimentally recorded and calculated VCD spectra of all enantiomers.