bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relapse profile of early breast cancer according to immunohistochemical subtypes: guidance for patient’s follow up?
Authors: Mejri Nesrine , Boussen H. , Labidi S. , Benna F. , Afrit M. , Rahal K. 
Published: March 2015

Purpose: To analyze the profile of annual recurrence rate (ARR) of patients with early breast cancer (BC) in Tunisia. Patients and methods: We classified 293 patients with histologically confirmed early BC relapsing after 1 year of follow up into three subgroups: hormone receptor (HR)+ ‘HR’ [estrogen receptor (ER)+ or progesterone receptor (PR)+ and human epidermal growth factor receptor 2 (HER2)–], triple negative ‘TN’ (ER–, PR– and HER2 score 0/1 or fluorescence in situ hybridization (FISH)/chromogenic in situ hybridization negative) and HER2 overexpression ‘HER2’ (HER2+). ARR was restricted to follow-up contribution of each specified time interval. The HR group was the reference group for comparison. Results: A higher proportion of patients who were up to 35 years old (18% versus 10%, p = 0.04), and patients with obesity (46% versus 26%, p = 0.045) was seen in the TN group. Median time to relapse (MTR) was shorter in TN and HER2 groups than in HR patients (20 and 29 months compared with 56 months, respectively, p < 0.001). In the HR group, the ARR was 22%, 16% and 10% at 3, 4 and 5 years respectively, becoming less than 3% at 7 years. In the TN group, 71% of patients relapsed during the first 2 years and the ARR declined rapidly to less than 1.5% after 4 years. In the HER2 group, the ARR peaked at 2 years (29%) and decreased significantly to 7% and 3% at 5 and 7 years respectively. Adjuvant trastuzumab delayed the MTR from 24 to 34 months ( p = 0.022). Conclusion: The relapse risk in Tunisian patients is higher in young women and patients with HER2+ and TN tumors. A long and close follow up is recommended for patients with HR and HER2. Conversely, we suggest that follow up in patients with TN could be spaced after 4 years (ARR being <1.5% after this period).
A Comparison of Rehabilitation Methods After Arthroscopic Rotator Cuff Repair
Authors: Yi Anthony , Villacis Diego , Yalamanchili Raj , Hatch George F. Rick 
Published: March 2015

Context: Despite the significant attention directed toward optimizing arthroscopic rotator cuff repair, there has been less focus on rehabilitation after rotator cuff repair surgery. Objective: To determine the effect of different rehabilitation protocols on clinical outcomes by comparing early versus late mobilization approaches and continuous passive mobilization (CPM) versus manual therapy after arthroscopic rotator cuff repair. Data Sources: PubMed was searched for relevant articles using the keywords rotator cuff, rotator, cuff, tears, lacerations, and rehabilitation to identify articles published from January 1980 to March 2014. Study Selection: Inclusion criteria consisted of articles of level 1 or 2 evidence, written in the English language, and with reported outcomes for early versus late mobilization or rehabilitation with CPM versus manual therapy after primary arthroscopic rotator cuff repair. Exclusion criteria consisted of articles of level 3, 4, or 5 evidence, non-English language, and those with significantly different demographic variables between study groups. Included studies were evaluated with the Consolidated Standards of Reporting Trials criteria. Study Design: Systematic review. Level of Evidence: Level 2. Data Extraction: Level of evidence, study type, number of patients enrolled, number of patients at final follow-up, length of follow-up, age, sex, rotator cuff tear size, surgical technique, and concomitant operative procedures were extracted from included articles. Postoperative data included clinical outcome scores, visual analog score for pain, shoulder range of motion, strength, and rotator cuff retear rates. Results: A total of 7 studies met all criteria and were included in the final analysis. Five studies compared early and late mobilization. Two studies compared CPM and manual therapy. Conclusion: In general, current data do not definitively demonstrate a significant difference between postoperative rotator cuff rehabilitation protocols that stress different timing of mobilization and use of CPM.
Success of High Tibial Osteotomy in the United States Military
Authors: Waterman Brian R. , Hoffmann Jeffrey D. , Laughlin Matthew D. , Burks Robert , Pallis Mark P. , Tokish John M. , Belmont Philip J. 
Published: March 2015

Background: Historically, high tibial osteotomy (HTO) has been performed to treat isolated medial gonarthrosis with varus deformity. Purpose: To evaluate the occupational outcomes of HTO in a high-demand military cohort. Study Design: Case-control study; Level of evidence, 3. Methods: A retrospective analysis of active duty service members undergoing HTO for coronal plane malalignment and/or intra-articular pathology was performed using the Military Health System between 2003 and 2011. Demographic parameters and surgical variables, including rates of perioperative complications, secondary surgery, activity limitations, and medical discharge, were extracted from electronic medical records. For the current study, cumulative failure was defined as conversion to knee arthroplasty or postoperative medical discharge for persistent knee dysfunction. Univariate and multivariate analyses were performed to identify statistical associations with cumulative failure after HTO. Results: A total of 181 service members (202 HTOs) were identified at an average follow-up of 47.5 months (range, 24-96 months). Mean age was 35.7 years (range, 19-55 years), and the majority were men (93%) and of enlisted rank (78%). All index procedures utilized a valgus-producing, opening wedge technique. Concomitant or staged procedures were performed in 87 patients (48%), including 40 ligamentous, 48 meniscal, and 48 chondral procedures. Complications occurred in 19.3% of knees (n = 39), with unplanned reoperation in 26 knees (12.8%). Fifty-three patients (40.7%) had minor activity limitations during military duty postoperatively. Eleven knees (5.4%) underwent conversion to total knee arthroplasty. The cumulative failure rate was 28.2% (n = 51) at 2- to 8-year follow-up. Patient age younger than 30 years at the time of surgery was associated with an independently higher risk of failure, whereas sex, concomitant/staged procedures, and perioperative complications were not significantly associated with subsequent failure. Conclusion: At short- to midterm follow-up, nearly 72% of all service members undergoing HTO returned to military duty and were free from conversion knee arthroplasty.
Stromal cell–mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling
Authors: Jitschin Regina , Braun Martina , Qorraj Mirjeta , Saul Domenica , Le Blanc Katarina , Zenz Thorsten , Mougiakakos Dimitrios 
Published: March 2015

Key Points
Stromal cells promote a glycolytic switch in CLL cells in a Notch-c-Myc signaling-dependent manner. Targeting glucose metabolism or the Notch-c-Myc signaling pathway could be exploited to breach stromal cell–mediated CLL drug resistance.
Therapeutic targeting of HES1 transcriptional programs in T-ALL
Authors: Schnell Stephanie A. , Ambesi-Impiombato Alberto , Sanchez-Martin Marta , Belver Laura , Xu Luyao , Qin Yue , Kageyama Ryoichiro , Ferrando Adolfo A. 
Published: March 2015

Key Points
NOTCH1 inhibits apoptosis via HES1-mediated repression of BBC3 in T-ALL. Perhexiline, a HES1 signature modulator drug, has strong antileukemic effects in vitro and in vivo.
Merozoite surface protein 1 recognition of host glycophorin A mediates malaria parasite invasion of red blood cells
Authors: Baldwin Michael R. , Li Xuerong , Hanada Toshihiko , Liu Shih-Chun , Chishti Athar H. 
Published: March 2015

Key PointsThe N-terminal subunit of MSP1 binds to a specific polypeptide region of GPA during merozoite invasion of human RBCs. The GPA–band 3 complex plays an essential role during malaria parasite invasion.
ICL-induced miR139-3p and miR199a-3p have opposite roles in hematopoietic cell expansion and leukemic transformation
Authors: Alemdehy Mir Farshid , Haanstra Jurgen R. , de Looper Hans W. J. , van Strien Paulina M. H. , Verhagen-Oldenampsen Judith , Caljouw Yvette , Sanders Mathijs A. , Hoogenboezem Remco , de Ru Arnoud H. , Janssen George M. C. , Smetsers Stephanie E. , Bierings Marc B. , van Veelen Peter A. , von Lindern Marieke , Touw Ivo P. , Erkeland Stefan J. 
Published: March 2015

Key PointsmiR-139-3p and miR-199a-3p, induced by ICL-induced damage, respectively, cause a loss and gain of hematopoietic progenitors. miR-199a-3p is an onco-microRNA (onco-miR) causing AML in a Cebpa-deficient mouse model. Target genes of miR-199a-3p include PRDX6, RUNX1, and SUZ12.
Effect of prednisone on type I interferon signature in rheumatoid arthritis: consequences for response prediction to rituximab
Authors: de Jong Tamarah D , Vosslamber Saskia , Blits Marjolein , Wolbink Gertjan , Nurmohamed Mike T , van der Laken Conny J , Jansen Gerrit , Voskuyl Alexandre E , Verweij Cornelis L 
Published: March 2015

Abstract
Introduction
Elevated type I interferon (IFN) response gene (IRG) expression has proven clinical relevance in predicting rituximab non-response in rheumatoid arthritis (RA). Interference between glucocorticoids (GCs) and type I IFN signaling has been demonstrated in vitro. Since GC use and dose are highly variable among patients before rituximab treatment, the aim of this study was to determine the effect of GC use on IRG expression in relation to rituximab response prediction in RA.

Methods
In two independent cohorts of 32 and 182 biologic-free RA patients and a third cohort of 40 rituximab-starting RA patients, peripheral blood expression of selected IRGs was determined by microarray or quantitative real-time polymerase chain reaction (qPCR), and an IFN-score was calculated. The baseline IFN-score was tested for its predictive value towards rituximab response in relation to GC use using receiver operating characteristics (ROC) analysis in the rituximab cohort. Patients with a decrease in disease activity score (∆DAS28) >1.2 after 6 months of rituximab were considered responders.

Results
We consistently observed suppression of IFN-score in prednisone users (PREDN+) compared to non-users (PREDN−). In the rituximab cohort, analysis on PREDN− patients (n = 13) alone revealed improved prediction of rituximab non-response based on baseline IFN-score, with an area under the curve (AUC) of 0.975 compared to 0.848 in all patients (n = 40). Using a group-specific IFN-score cut-off for all patients and PREDN− patients alone, sensitivity increased from 41% to 88%, respectively, combined with 100% specificity.

Conclusions
Because of prednisone-related suppression of IFN-score, higher accuracy of rituximab response prediction was achieved in PREDN− patients. These results suggest that the IFN-score-based rituximab response prediction model could be improved upon implementation of prednisone use.
Generalized von Neumann-Jordan constant and its relationship to the fixed point property
Authors: Cui Yunan , Huang Wan , Hudzik Henryk , Kaczmarek Radosław 
Published: March 2015

AbstractWe introduce a new geometric constant $C_{NJ}^{(p)}(X)$

C

N
J

(
p
)

(
X
)
for a Banach space X, called a generalized von Neumann-Jordan constant. Next, it is shown that $1\leq C_{NJ}^{(p)}(X)\leq2$
1
≤

C

N
J

(
p
)

(
X
)
≤
2
for any Banach space X and that the right hand side inequality is sharp if and only if X is uniformly non-square. Moreover, a relationship between the James constant $J(X)$
J
(
X
)
and $C_{NJ}^{(p)}(X)$

C

N
J

(
p
)

(
X
)
is presented. Finally, the generalized von Neumann-Jordan constant of the Lebesgue space $L_{r}([0,1])$

L
r

(
[
0
,
1
]
)
is calculated and a relationship between $C_{NJ}^{(p)}(X)$

C

N
J

(
p
)

(
X
)
and the fixed point property is found.
The effect of sharing a mother tongue with peers: evidence from North Carolina middle schools
Authors: Ahn Thomas , Jepsen Christopher 
Published: March 2015

Abstract
This paper provides the first analysis of the relationship between the language mix of Limited English Proficient (LEP) peers and student achievement, using detailed panel data from 2006 to 2012. Percent LEP has a negative association with mathematics and reading test scores, more so for non-LEP students than for LEP students. The overall language mix of LEP students has little if any discernable relationship with achievement. For LEP students, having more LEP peers speak their mother tongue is positively associated with reading achievement and negatively associated with mathematics achievement.
Translocation t(11;14) Is Associated With Adverse Outcome in Patients With Newly Diagnosed AL Amyloidosis When Treated With Bortezomib-Based Regimens
Authors: Bochtler Tilmann , Hegenbart Ute , Kunz Christina , Granzow Martin , Benner Axel , Seckinger Anja , Kimmich Christoph , Goldschmidt Hartmut , Ho Anthony D. , Hose Dirk , Jauch Anna , Schönland Stefan O. 
Published: March 2015

Purpose Bortezomib has become a cornerstone in the treatment of AL amyloidosis. In this study, we addressed the prognostic impact of cytogenetic aberrations for bortezomib-treated patients. Patients and Methods We analyzed a consecutive series of 101 patients with AL amyloidosis treated with bortezomib-dexamethasone as first-line treatment by interphase fluorescence in situ hybridization (iFISH). Patients were ineligible for high-dose chemotherapy, which would put them at risk for cardiac or renal failure, and thus represented a poor-risk group. Results Presence of t(11;14), versus its absence, was associated with inferior hematologic event-free survival (median, 3.4 v 8.8 months, respectively; P = .002), overall survival (median, 8.7 v 40.7 months, respectively; P = .05), and remission rate (≥ very good partial remission; 23% v 47%, respectively; P = .02). In multivariable Cox regression models incorporating established hematologic and clinical risk factors, t(11;14) was an independent adverse prognostic marker for hematologic event-free survival (hazard ratio, 2.94; 95% CI, 1.37 to 6.25; P = .006) and overall survival (hazard ratio, 3.13; 95% CI, 1.16 to 8.33; P = .03), but not for remission (≥ very good partial remission). Markedly, the multiple myeloma high-risk iFISH aberrations t(4;14), t(14;16), del(17p), and gain of 1q21 conferred no adverse prognosis in this bortezomib-dexamethasone–treated group. After backward variable selection, the final multivariable model was validated in a consecutive series of 32 patients treated with bortezomib, dexamethasone, and cyclophosphamide. Conclusion iFISH results are important independent prognostic factors in AL amyloidosis. In contrast to our recently published results with melphalan and dexamethasone standard therapy, bortezomib is less beneficial to patients harboring t(11;14), whereas it effectively alleviates the poor prognosis inherent to high-risk aberrations. Given the discrepant response to different treatment modalities, iFISH may help to guide therapeutic choices in these poor-risk patients requiring rapid hematologic response.
Acceptability of Home‐Based Chlamydia And Gonorrhea Testing Among a National Sample Of Sexual Minority Young Adults
Authors: McRee Annie‐Laurie , Esber Allahna , Reiter Paul L. 
Published: March 2015

CONTEXTSTDs are common among older adolescents and young adults; hence, STD screening is a public health priority. Home‐based STD testing could be a strategy to improve screening rates, particularly among at‐risk populations, including sexual minority (i.e., nonheterosexual) young adults.METHODSData were collected from a national sample of 971 sexual minority young adults aged 18–26 through an online survey in the fall of 2013. Logistic regression analyses identified associations between respondents’ characteristics and their willingness to use a home‐based test for chlamydia and gonorrhea.RESULTSA greater proportion of men than of women were willing to use a home‐based STD test (81% vs. 68%). Willingness was more likely among gay than among bisexual men, among men insured through their parents than among the uninsured and among those who had had two or more sexual partners in the past year than among those who had had fewer (adjusted odds ratios, 2.0–2.2). Among men, students were less likely than the employed to report willingness for home‐based testing (0.4). Among women, willingness was more likely among those who reported at least two partners in the past year than among those who reported fewer (1.6). Overall, respondents’ most common concerns about home‐based STD testing regarded test accuracy, their ability to do the test correctly and their preference to see a doctor for testing.CONCLUSIONSHome‐based STD testing may be a promising strategy for screening sexual minority young adults; understanding correlates of willingness and young adults’ concerns may help inform self‐testing programs.
Linear Generalized Synchronization Using Bidirectional Coupling
Authors: Nandan Mauparna , Bhowmick Sourav K. , Pal Pinaki 
Published: March 2015

Abstract
We present a bidirectional coupling strategy to establish targeted linear generalized synchronization between two mismatched continuous chaotic dynamical systems. The strategy is based on Routh–Hurwitz stability criterion. Using the proposed coupling scheme we are able to achieve stable linear generalized synchronization between two mismatched chaotic dynamical systems. The coupling strategy is illustrated using the paradigmatic Lorenz, Rössler and Sprott systems.
Quasi-Hadamard differentiability of general risk functionals and its application
Authors: Krätschmer Volker , Schied Alexander , Zähle Henryk 
Published: March 2015

Abstract
We apply a suitable modification of the functional delta method to statistical functionals that arise from law-invariant coherent risk measures. To this end we establish differentiability of the statistical functional in a relaxed Hadamard sense, namely with respect to a suitably chosen norm and in the directions of a specifically chosen “tangent space”. We show that this notion of quasi-Hadamard differentiability yields both strong laws and limit theorems for the asymptotic distribution of the plug-in estimators. Our results can be regarded as a contribution to the statistics and numerics of risk measurement and as a case study for possible refinements of the functional delta method through fine-tuning the underlying notion of differentiability.
Handheld Echocardiography Versus Auscultation for Detection of Rheumatic Heart Disease
Authors: Godown Justin , Lu Jimmy C. , Beaton Andrea , Sable Craig , Mirembe Grace , Sanya Richard , Aliku Twalib , Yu Sunkyung , Lwabi Peter , Webb Catherine L. , Ensing Gregory J. 
Published: March 2015

BACKGROUND:
Rheumatic heart disease (RHD) remains a major public health concern in developing countries, and routine screening has the potential to improve outcomes. Standard portable echocardiography (STAND) is far more sensitive than auscultation for the detection of RHD but remains cost-prohibitive in resource-limited settings. Handheld echocardiography (HAND) is a lower-cost alternative. The purpose of this study was to assess the incremental value of HAND over auscultation to identify RHD.

METHODS:
RHD screening was completed for schoolchildren in Gulu, Uganda, by using STAND performed by experienced echocardiographers. Any child with mitral or aortic regurgitation or stenosis plus a randomly selected group of children with normal STAND findings underwent HAND and auscultation. STAND and HAND studies were interpreted by 6 experienced cardiologists using the 2012 World Heart Federation criteria. Sensitivity and specificity of HAND and auscultation for the detection of RHD and pathologic mitral or aortic regurgitation were calculated by using STAND as the gold standard.

RESULTS:
Of 4773 children who underwent screening with STAND, a subgroup of 1317 children underwent HAND and auscultation. Auscultation had uniformly poor sensitivity for the detection of RHD or valve disease. Sensitivity was significantly improved by using HAND compared with auscultation for the detection of definite RHD (97.8% vs 22.2%), borderline or definite RHD (78.4% vs 16.4%), and pathologic aortic insufficiency (81.8% vs 13.6%).

CONCLUSIONS:
Auscultation alone is a poor screening test for RHD. HAND significantly improves detection of RHD and may be a cost-effective screening strategy for RHD in resource-limited settings.
Medical Providers’ Understanding of Sex Trafficking and Their Experience With At-Risk Patients
Authors: Beck Megan E. , Lineer Megan M. , Melzer-Lange Marlene , Simpson Pippa , Nugent Melodee , Rabbitt Angela 
Published: March 2015

BACKGROUND AND OBJECTIVES:
Sex trafficking (ST) victims have unique medical and mental health needs and are often difficult to identify. Our objectives were to evaluate knowledge gaps and training needs of medical providers, to demonstrate the importance of provider training to meet the pediatric ST victim’s specific needs, and to highlight barriers to the identification of and response to victims.

METHODS:
A survey was sent to providers in specialties that would be most likely to encounter victims of ST. Participants included physicians, nurses, physician assistants, social workers, and patient and family advocates at multiple hospitals and medical clinics in urban, suburban, and rural locations.

RESULTS:
Of ∼500 survey recipients, 168 participants responded. In 2 clinical vignettes, 48% correctly classified a minor as an ST victim, and 42% correctly distinguished an ST victim from a child abuse victim. In all, 63% of respondents said that they had never received training on how to identify ST victims. Those with training were more likely to report ST as a major problem locally (P ≤ .001), to have encountered a victim in their practice (P ≤ .001), and to have greater confidence in their ability to identify victims (P ≤ .001). The greatest barriers to identification of victims reported were a lack of training (34%) and awareness (22%) of ST.

CONCLUSIONS:
Health care providers demonstrate gaps in knowledge and awareness of ST, specifically of pediatric victims, that correlate with their limited experience and training. Training is crucial to improve identification of these victims and provide appropriate care for their specific needs.