bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Efektivitas Dan Kontribusi Dari Pajak Bumi Dan Bangunan Perdesaan Dan Perkotaan (PBB-P2) Terhadap Pendapatan Asli (PAD) (Survei pada 35 Kabupaten dan Kota di Jawa Tengah Pada Tahun 2014-2018)
Authors: Putri Alifiya Sandyah , Adi Priyo Hari 
Published: July 2024

Wewenang pemerintah daerah dalam mengatur PBB-P2 diatur dalam Undang-undang Nomor 28 Tahun 2009 tentang pajak daerah dan retribusi daerah. Pemerintah mewajibkan per tahun 2014 agar semua kabupaten dan kota di Indonesia melaksanakan kewajibannya untuk mengatur PBB-P2. Pengalihan PBB-P2 dari pajak pusat menjadi pajak daerah ini guna meningkatkan otonomi daerah. Karena adanya pengalihan maka secara langsung menambah sektor penerimaan bagi PAD. PAD merupakan salah satu sektor penunjang belanja daerah, maka dari itu antara PBB-P2, PAD, dan belanja daerah saling terkait. Penelitian ini menggunakan 35 kabupaten dan kota di Jawa Tengah pada periode tahun 2014 â€“ 2018. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas dan kontribusi PBB-P2 terhadap PAD serta pengaruhnya terhadap belanja daerah setelah adanya pengalihan menjadi pajak daerah. Penelitian ini menggunakan data sekunder yang diperoleh dari Direktorat Jenderal Perimbangan Keuangan serta laporan daerah dalam angka.

Keywords (Kata Kunci) : Efektivitas PBB-P2, Kontribusi PBB-P2, PAD, Belanja Daerah
Era Digital : Influencer Dalam Sistem Politik Indonesia
Authors: Ilham Ilham , Muttaqin M Zaenul , Idris Usman , Renyaan Dorthea 
Published: July 2024

Kajian ini terfokus membahas tentang peran influencer dalam sistem politik Indonesia di era digitalisasi. Mengingat dewasa ini, para influencer semakin meluas ranah keterlibatannya hingga merambah ke dunia politik. Kajian ini memanfaatkan jenis penelitian kepustakaan, dimana data dikumpulkan dari pelbagai sumber literatur dengan melakukan analisis teks dan wacana. Selanjutnya dilakukan cross checkÂ dengan tujuan menguji validitas data. Hasil kajian iniÂ menunjukkan bahwa terdapat pola segitiga kekuatan dalam sistem politik, masing-masing; government, private sector dan civil society yang berperan penting dalam memotori proses pengambilan kebijakan. Pada konteks ini, influencer kemudian dikategorikan sebagai bagian dari civil society yang bertindak sebagai pemberi input dan feedback dalam proses pengambilan kebijakan. Di ranah Pemilihan Umum [Pemilu], pelibatan influencer dari kalangan selebritisÂ bertujuan untuk membentuk opini publik, mendapatkan dukungan masyarakat, bahkan memenangkan kompetisi. Aura positif yang dimiliki oleh influencer juga dimanfaatkan oleh penyelenggara pemilu [KPU] dalam peningkatan partisipasi pemilih. Realita ini, banyak ditemui dalam penghelatan Pilkada di sejumlah daerah di Indonesia. Sebagai catatan penutup, perkembangan media sosial lambat laun mengalami pergeseran menjadi alat propaganda politik, terlebih di masa Pemilihan Kepala Daerah [Pilkada] di Indonesia, maka perlu dilakukan pendewasaan diri oleh masyarakat dalam bermedia sosial yang dimulai dari langkah sederhana seperti dengan melakukan cross check terlebih dahulu terhadap beragam informasi atau berita disajikan.
Reformasi Gaya Kepemimpinan Formal dalam Pemerintahan di Kabupaten Mamberamo Tengah
Authors: Wanimbo Wim , Frank Simon Abdi K. 
Published: July 2024

This article is the result of research on reformation of format leadership style in Mamberamo Tengah regency. The main problem of this research is to know how the formal leadership in this context (regent) and how the public service practice with base on “good governance” principle in development for Mamberamo Tengah’s community.This research used descriptive qualitative approach. The data were collected by field observation, interview and literature study. The results show that so really need an action of reformation on regent’s formal leadership style as a head of Mamberamo Tengah area for the sake of “good governance” principle materialized in public service and development for local community. This is because in his leadership’s style that so prominently is toxic leadership that contradiction with local Indohoki77 memastikan bahwa semua permainan yang ditawarkan adalah adil dan transparan leadserhip culture values is Ap kain (Big Man) who is generous.
Clinical and Genetic Heterogeneity of Nuclear Envelopathy Related Muscular Dystrophies in an Indian Cohort
Authors: Baskar Dipti , Preethish-Kumar Veeramani , Polavarapu Kiran , Vengalil Seena , Nashi Saraswati , Menon Deepak , Ganaraja Valakunja Harikrishna , Girija Manu Santhappan , Nandeesh Bevinahalli Nanjegowda , Arunachal Gautham , Nalini Atchayaram 
Published: July 2024

Introduction: Nuclear envelopathies occur due to structural and/or functional defects in various nuclear envelope proteins such as lamin A/C and lamin related proteins. This study is the first report on the phenotype-genotype patterns of nuclear envelopathy-related muscular dystrophies from India. Methods: In this retrospective study, we have described patients with genetically confirmed muscular dystrophy associated with nuclear envelopathy. Data on clinical, laboratory findings and muscle MRI were collected. Results: Sixteen patients were included with median age at onset of 3 years (range: 1 month – 17 years). Three genes were involved: LMNA (11, 68.75%), EMD (4, 25%) and SYNE1 (1, 6.25%). The 11 patients with LMNA variants were Congenital muscular dystrophy (MDCL)=4, Limb Girdle Muscular Dystrophy (LGMD1B)=4 and Emery-Dreifuss Muscular Dystrophy (EDMD2)=3. On muscle biopsy, one patient from each laminopathy phenotype ( n = 3) revealed focal perivascular inflammatory infiltrate. Other notable features were ophthalmoparesis in one and facial weakness in one. None had cardiac involvement. Patients with EDMD1 had both upper (UL) and lower limb (LL) proximo-distal weakness. Cardiac rhythm disturbances such as sick sinus syndrome and atrial arrhythmias were noted in two patients with EDMD1. Only one patient with variant c.654_658dup ( EMD) lost ambulation in the 3rd decade, 18 years after disease onset. Two had finger contractures with EMD and SYNE1 variants respectively. All patients with LMNA and SYNE1 variants were ambulant at the time of evaluation. Mean duration of illness (years) was 11.6±13 (MDCL), 3.2±1.0 (EDMD2), 10.4±12.8 (LGMD1B), 11.8±8.4 (EDMD1) and 3 (EDMD4). One patient had a novel SYNE1 mutation (c.22472dupA, exon 123) and presented with UL phenotype and prominent finger and wrist contractures. Conclusion: The salient features included ophthalmoparesis and facial weakness in LMNA, prominent finger contractures in EMD and SYNE1 and upper limb phenotype with the novel pathogenic variant in SYNE1.
Risk Factors for Postoperative Delirium Severity After Deep Brain Stimulation Surgery in Parkinson’s Disease
Authors: Astalosch Melanie , Mousavi Mahta , Ribeiro Luísa Martins , Schneider Gerd-Helge , Stuke Heiner , Haufe Stefan , Borchers Friedrich , Spies Claudia , von Hofen-Hohloch Judith , Al-Fatly Bassam , Ebersbach Georg , Franke Christiana , Kühn Andrea A. , Kübler-Weller Dorothee 
Published: July 2024

Background: Postoperative delirium (POD) is a serious complication following deep brain stimulation (DBS) but only received little attention. Its main risk factors are higher age and preoperative cognitive deficits. These are also main risk factors for long-term cognitive decline after DBS in Parkinson’s disease (PD). Objective: To identify risk factors for POD severity after DBS surgery in PD. Methods: 57 patients underwent DBS (21 female; age 60.2±8.2; disease duration 10.5±5.9 years). Preoperatively, general, PD– and surgery-specific predictors were recorded. Montreal Cognitive Assessment and the neuropsychological test battery CANTAB ConnectTM were used to test domain-specific cognition. Volumes of the cholinergic basal forebrain were calculated with voxel-based morphometry. POD severity was recorded with the delirium scales Confusion Assessment Method for Intensive Care Unit (CAM-ICU) and Nursing Delirium Scale (NU-DESC). Spearman correlations were calculated for univariate analysis of predictors and POD severity and linear regression with elastic net regularization and leave-one-out cross-validation was performed to fit a multivariable model. Results: 21 patients (36.8%) showed mainly mild courses of POD following DBS. Correlation between predicted and true POD severity was significant (spearman rho = 0.365, p = 0.001). Influential predictors were age ( p < 0.001), deficits in attention and motor speed ( p = 0.002), visual learning ( p = 0.036) as well as working memory ( p < 0.001), Nucleus basalis of Meynert volumes ( p = 0.003) and burst suppression ( p = 0.005). Conclusions: General but also PD– and surgery-specific factors were predictive of POD severity. These findings underline the multifaceted etiology of POD after DBS in PD. Valid predictive models must therefore consider general, PD– and surgery-specific factors.
Modeling of Parkinson’s Disease Progression and Implications for Detection of Disease Modification in Treatment Trials
Authors: Ribba Benjamin , Simuni Tanya , Marek Kenneth , Siderowf Andrew , Diack Cheikh , Pierrillas Philippe Bernard , Monnet Annabelle , Ricci Benedicte , Nikolcheva Tania , Pagano Gennaro 
Published: July 2024

Background: Objectively measuring Parkinson’s disease (PD) signs and symptoms over time is critical for the successful development of treatments aimed at halting the disease progression of people with PD. Objective: To create a clinical trial simulation tool that characterizes the natural history of PD progression and enables a data-driven design of randomized controlled studies testing potential disease-modifying treatments (DMT) in early-stage PD. Methods: Data from the Parkinson’s Progression Markers Initiative (PPMI) were analyzed with nonlinear mixed-effect modeling techniques to characterize the progression of MDS-UPDRS part I (non-motor aspects of experiences of daily living), part II (motor aspects of experiences of daily living), and part III (motor signs). A clinical trial simulation tool was built from these disease models and used to predict probability of success as a function of trial design. Results: MDS-UPDRS part III progresses approximately 3 times faster than MDS-UPDRS part II and I, with an increase of 3 versus 1 points/year. Higher amounts of symptomatic therapy is associated with slower progression of MDS-UPDRS part II and III. The modeling framework predicts that a DMT effect on MDS-UPDRS part III could precede effect on part II by approximately 2 to 3 years. Conclusions: Our clinical trial simulation tool predicted that in a two-year randomized controlled trial, MDS-UPDRS part III could be used to evaluate a potential novel DMT, while part II would require longer trials of a minimum duration of 3 to 5 years underscoring the need for innovative trial design approaches including novel patient-centric measures.
Pengaruh Harga Emas dan Nilai Dolar Terhadap Fluktuasi Debt to Equity Ratio Perusahaan PT. Adaro Energy Periode 1998-2023
Authors: Arif Surahman  , Iman Lubis  , Nani Rusnaeni  
Published: July 2024

ABSTRAK

Penelitian ini bertujuan untuk menganalisis pengaruh harga emas dan nilai dolar terhadap Debt to Equity Ratio (DER) pada PT. Adaro Energy selama periode 1998-2023. Data yang digunakan adalah data sekunder yang diperoleh dari laporan keuangan tahunan perusahaan serta sumber-sumber harga emas dan nilai tukar dolar. Metode analisis yang digunakan meliputi regresi berganda dan uji asumsi klasik menggunakan SPSS 25. Hasil dari penelitian menunjukkan bahwa: Pertama, harga emas memiliki pengaruh signifikan dan negatif terhadap DER, dengan peningkatan harga emas cenderung menurunkan DER. Kedua, nilai dolar tidak memiliki pengaruh signifikan terhadap DER. Ketiga, model regresi yang mencakup variabel harga emas dan nilai dolar secara simultan memiliki pengaruh yang signifikan, yang mana hal ini menunjukkan bahwa perubahan pada harga emas dan nilai dolar memberikan penjelasan yang signifikan terhadap variasi dalam DER. Kesimpulan dari penelitian ini adalah bahwa fluktuasi harga emas merupakan faktor penting yang mempengaruhi struktur keuangan perusahaan, khususnya dalam hal DER, sementara nilai dolar tidak menunjukkan pengaruh yang signifikan.

Kata Kunci: Harga, Emas, Nilai, Dolar, Debt to Equity Ratio, PT. Adaro Energy
A case report of incidental finding of compound odontoma on a panoramic radiograph
Authors: Agung Anak Agung Gde Dananjaya , Laurentina Made , Janadewi I Gusti Agung , Sukmadewi Putri Marina , Epsilawati Lusi 
Published: July 2024

Objectives: The purpose of this case study was to report the compound odontoma’s founding in a panoramic radiograph.
Case Report: An 11-year-old female patient came with her parents to the pedodontics of Dental Hospital Padjadjaran Bandung with the chief complaint of a palatal bite with an unerupted left maxillary posterior tooth. Then the patient took the panoramic and cephalometry radiographs to confirm the diagnosis. The result from the panoramic radiograph was that there were multiple radioopaques with a tooth-like structure contained, surrounded by a radiolucent band, and the lesion had a corticated, well-defined border. Radiodiagnosis has been established as a compound odontoma associated with an unerupted maxillary second premolar.
Conclusion: Compound odontoma is a benign tumor that often occurs at the age of tooth development and often causes delayed tooth eruption. Panoramic radiographs as radiographic aids play a very important role in identifying these tumors.
Age-related mandibular condyle morphological variations: a panoramic radiography study at RSGMP Universitas Airlangga
Authors: Mulyani Sri Wigati Mardi , Astuti Eha Renwi , Wahyuni Otty Ratna , Savitri Yunita , Nurrachman Aga Satria , Ramadhani Nastiti Faradilla , Putri Kharisma Gaprila , Jihan Jihan 
Published: July 2024

Objectives: This research aims to find out the variations of the mandibular condyle shape based on age on panoramic radiography.
Materials and Methods: This study uses secondary data from 200 digital panoramic radiographs of patients at the dental hospital (RSGM) of Universitas Airlangga aged 20-65 years in 2019, 2020, and 2021, which have met the inclusion and exclusion criteria. Data is presented in the form of tables and graphs with simple statistical calculations, and reliability tests were carried out with intraclass correlation (ICC) methods using SPSS.
Results: There are variations of the condyle shape in five age groups, the age I (20-25 Years), age II (26-35 years), age III (36-45 years), age IV (46-55 years), age V (56-65 years).
Conclusion: There are condyle shape variabilities in several age groups. In age I (20-25 years), age II (26-35 years), age III (36-45 years), and age IV (46-55 years) the most variation of the condyle shape is rounded, at age V (56-65 years) the most variation of the condyle shape is rounded and pointed. Furthermore, the morphology of the condylar structures may exhibit variances and are not consistently uniform.
Simulation study on the thermal effect of continuous laser heating quartz materials
Authors: Li Wei , Wu Jichuan , Li Yanglong , Wu Lingyuan , Fu Bo 
Published: July 2024

The continuous development and application of laser technology, and the increasing energy and power of laser output have promoted the development of various types of laser optical systems. The optical components based on quartz materials are key components of high-power laser systems, and their quality directly affects the load capacity of the system. Due to the photothermal effect when the laser interacts with the quartz material and generates extremely high temperatures in a short period of time, it is impossible to experimentally solve the phenomena and physical mechanisms under extreme conditions. Therefore, it is very important to select a suitable method to investigate the thermal effect of intense laser interaction with quartz materials and explain the related physical mechanism. In this study, a three-dimensional quarter-symmetric laser heating quartz material geometry model by using nonlinear transient finite element method was established, and its transient temperature field distribution of the quartz material after being heated by a 1,064 nm continuous laser was investigated. In addition, the influence of different laser parameters (laser spot radius, heat flux and irradiation time), material parameters (material thickness, material absorption rate of laser) on the thermal effect of heating quartz material were also studied. When the laser heat flux is 20 W/cm2, the diameter of the laser spot is 10 cm, the irradiation time is 600 s and the thickness is 4 cm, the temperature after laser heating can reach 940.18°C, which is far lower than the melting point. In addition, the temperature maximum probes were set at the overall model, spot edge and rear surface respectively, and their temperature rise curves with time were obtained. It is also found that there is a significant hysteresis period for the rear surface temperature change of the quartz material compared with the overall temperature change due to heat conduction. Finally, the method proposed can also be applied to the laser heating of other non-transparent materials.
Immersive learning platforms: analyzing virtual reality contribution to competence development in higher education—a systematic literature review
Authors: Cabrera-Duffaut Augusto , Pinto-Llorente Ana María , Iglesias-Rodríguez Ana 
Published: July 2024

BackgroundThis study evaluates the effectiveness and pedagogical integration of Virtual Reality (VR), exploring its application in various educational contexts. In this systematic literature review, the role of virtual reality in enhancing competency development within higher education is examined.MethodsThe search was conducted in two databases (Scopus and Web of Science) following the PRISMA method guidelines. Inclusion criteria were limited to studies that used virtual reality as a tool within the classroom, analyzing the competencies developed through its application.ResultsOut of the 1,671 articles retrieved, 61 full texts were selected for review, resulting in 27 academic articles published in the last five years. The findings highlight the capacity of virtual reality to foster interpersonal skills while simultaneously addressing the challenges of its integration.DiscussionThe adoption of Virtual Reality (VR) in higher education is notable for its immersive learning experiences. Despite VR’s significant contribution to education, its widespread integration faces challenges, including the high costs of VR technology and the lack of specialized educational software, which limits its accessibility across various academic disciplines.ConclusionThe advent of global technological advancements has unveiled numerous opportunities within the educational sector, with VR emerging as a transformative technology that offers immersive learning experiences, propelling educational methodologies beyond traditional boundaries. Through this SLR, it becomes evident that the application of VR in education transcends mere knowledge transfer, facilitating the development of critical competencies.Systematic review registrationhttp://bit.ly/3SyKPhv.
Deciphering the immune-metabolic nexus in sepsis: a single-cell sequencing analysis of neutrophil heterogeneity and risk stratification
Authors: Jin Shaoxiong , Zhang Huazhi , Lin Qingjiang , Yang Jinfeng , Zeng Rongyao , Xu Zebo , Sun Wendong 
Published: July 2024

BackgroundMetabolic dysregulation following sepsis can significantly compromise patient prognosis by altering immune-inflammatory responses. Despite its clinical relevance, the exact mechanisms of this perturbation are not yet fully understood.MethodsSingle-cell RNA sequencing (scRNA-seq) was utilized to map the immune cell landscape and its association with metabolic pathways during sepsis. This study employed cell-cell interaction and phenotype profiling from scRNA-seq data, along with pseudotime trajectory analysis, to investigate neutrophil differentiation and heterogeneity. By integrating scRNA-seq with Weighted Gene Co-expression Network Analysis (WGCNA) and machine learning techniques, key genes were identified. These genes were used to develop and validate a risk score model and nomogram, with their efficacy confirmed through Receiver Operating Characteristic (ROC) curve analysis. The model’s practicality was further reinforced through enrichment and immune characteristic studies based on the risk score and in vivo validation of a critical gene associated with sepsis.ResultsThe complex immune landscape and neutrophil roles in metabolic disturbances during sepsis were elucidated by our in-depth scRNA-seq analysis. Pronounced neutrophil interactions with diverse cell types were revealed in the analysis of intercellular communication, highlighting pathways that differentiate between proximal and core regions within atherosclerotic plaques. Insight into the evolution of neutrophil subpopulations and their differentiation within the plaque milieu was provided by pseudotime trajectory mappings. Diagnostic markers were identified with the assistance of machine learning, resulting in the discovery of PIM1, HIST1H1C, and IGSF6. The identification of these markers culminated in the development of the risk score model, which demonstrated remarkable precision in sepsis prognosis. The model’s capability to categorize patient profiles based on immune characteristics was confirmed, particularly in identifying individuals at high risk with suppressed immune cell activity and inflammatory responses. The role of PIM1 in modulating the immune-inflammatory response during sepsis was further confirmed through experimental validation, suggesting its potential as a therapeutic target.ConclusionThe understanding of sepsis immunopathology is improved by this research, and new avenues are opened for novel prognostic and therapeutic approaches.
Multiple cerebral infarctions after intravenous immunoglobulin for Guillain–Barré syndrome: two case reports and review of the literature
Authors: Wang Weisen , Feng Chunhua , Liu Yanqun , Tao Yi , Bi Xiaoying , Hou Xiaojun 
Published: July 2024

BackgroundGuillain–Barré syndrome (GBS) is a polyradiculoneuropathy mediated by the immune system and is the primary reason for acute flaccid paralysis. Intravenous immunoglobulin (IVIg) is a recognized immunotherapeutic drug that can accelerate recovery from GBS. Limited literature exists concerning cerebral infarction complications with IVIg following its use in the treatment of GBS.Case presentationA patient was diagnosed with the acute inflammatory demyelinating polyradiculoneuropathy subtype of GBS, while another patient was diagnosed with the acute bulbar palsy variant of GBS 2 years prior and experienced a relapse of GBS. Both patients received immunoglobulin therapy, during which multiple acute cerebral infarctions were detected using magnetic resonance imaging. Both patients had a history of coronary artery atherosclerotic heart disease and vertebral artery stenosis, and D-dimer and fibrinogen degradation products were significantly elevated after immunoglobulin therapy.ConclusionsThe risk of cerebral infarction associated with IVIg is generally low in patients with different GBS variants. Nevertheless, the occurrence of cerebral infarction associated with IVIg might not be insignificant in older patients with vascular risk factors and should be carefully monitored.