bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical and histopathological characteristics of a family with R1141X mutation of pseudoxanthoma elasticum – presymptomatic testing and lack of carrier phenotypes
Authors: Akoglu Gulsen , Li Qiaoli , Gokoz Ozay , Gazyagci Ali Serhan , Uitto Jouni 
Published: May 2013

AbstractBackgroundPseudoxanthoma elasticum (PXE) is a heritable ectopic mineralization disorder affecting cutaneous, ocular, and cardiovascular systems, caused by mutations in the ABCC6 gene. PXE presents with a marked clinical and genetic heterogeneity. Furthermore, heterozygous carriers may present with limited histopathological features. This study was conducted to investigate a patient with PXE and her family members clinically, histopathologically, and genetically.MethodsClinical and histopathological examinations and mutation analyses of ABCC6 gene were performed.ResultsLesional skin biopsy of the patient with PXE demonstrated clumping and fragmentation of elastic fibers, and calcification in the dermis. Non‐lesional axillary skin samples of the husband, daughter, and older son were histopathologically normal. The skin from a similar region of a younger son revealed elastic fibers with some fragmentation and clumping but no mineralization. The patient with PXE was homozygous for the R1141X mutation in the ABCC6 gene. The husband had wild‐type alleles, while all children were heterozygous carriers. Daily treatment of antioxidant therapy with tocopherol acetate and ascorbic acid was prescribed to the patient with PXE. After one year, both clinical and histopathological regression of the lesions was observed; however, lesions began to progress during the additional 6‐month period of treatment.ConclusionThe mutation analyses of ABCC6 gene are important to determine the genotype of both patients with PXE and putative heterozygous carriers, as histopathological features of carriers may differ even in the same family. The role of antioxidant therapy for PXE is unclear, and there is a need for controlled clinical trials.
Clinical analysis of the PADUA and the RENAL scoring systems for renal neoplasms: A retrospective study of 245 patients undergoing laparoscopic partial nephrectomy
Authors: Zhang Zhong‐Yuan , Tang Qi , Li Xue‐Song , Zhang Qian , Mayer Wesley A , Wu Jing‐Yun , Yang Xue‐Dong , Zhang Xiao‐Chun , Wang Xiao‐Ying , Zhou Li‐Qun 
Published: May 2013

ObjectiveTo investigate the clinical significance of preoperative aspects and dimensions used for anatomic (PADUA) and radius exophytic/endophytic nearness anterior/posterior location (RENAL) scoring systems for renal neoplasms in patients undergoing laparoscopic partial nephrectomy.MethodsA retrospective analysis was carried out on clinical data of 245 Chinese patients with renal neoplasms undergoing laparoscopic partial nephrectomy from June 2008 to June 2012. The perioperative complications and variables, as well as PADUA and RENAL score, were compared.ResultsThe PADUA and RENAL scoring systems were significantly associated with percent change in estimated glomerular filtration rate (P = 0.032 and P = 0.026 respectively), whereas the RENAL scoring system was also significantly associated with warm ischemia time (P = 0.032). On multivariate analysis, both scores were able to predict percent change in estimated glomerular filtration rate (PADUA, P = 0.011; RENAL, P = 0.028). There were no significant associations between the two scoring systems assessed and the occurrence of complications or tumor stage. The correlation between PADUA classification and RENAL nephrometry score was significant (P < 0.0001). Fleiss' generalized kappa was 0.69–0.89 for the various components of the PADUA score and 0.67–0.89 for the RENAL nephrometry components.ConclusionsThe PADUA classification and RENAL nephrometry score are comprehensive assessment tools for delineating renal tumor anatomy. The reproducibility of the PADUA and RENAL scores is substantial, but further research is required to evaluate its performance in more accurately predicting operative and patient‐related outcomes.
The association of skin conditions with housing conditions among North Carolina Latino migrant farm workers
Authors: Gustafson Cheryl J. , Feldman Steven R. , Quandt Sara A. , Isom Scott , Chen Haiying , Spears Chaya R. , Arcury Thomas A. 
Published: May 2013

AbstractBackgroundSkin conditions are common among Latino migrant farm workers. Although many skin conditions are related to occupational exposures, poor housing conditions may also contribute to skin ailments in migrant farm workers.ObjectivesTo evaluate the association between housing conditions and skin conditions among Latino migrant farm workers.Materials and methodsA cross‐sectional study design using interview questionnaires, home inspections, and environmental sampling was implemented to document housing quality of farm worker camps/homes and the prevalence of self‐reported skin conditions in Latino migrant farm workers. Interviews were completed with 371 farm workers residing in 186 of the 226 camps (camp response rate 82.3%).ResultsSelf‐reported pruritus (31%), rash (25%), scaling (12%), blisters (11%), and ingrown nails (10%) were common among the participants. Pruritus was more likely to be reported by farm workers living in dwellings without air‐conditioning (P < 0.05). Rash was associated with dwellings reported to have a low humidity (P < 0.05). Scaling was more likely to be reported by farm workers living in dwellings with indoor temperatures in the thermal discomfort range (P < 0.05). No statistically significant associations were detected for indoor allergens and self‐reported skin ailments among migrant farm workers.ConclusionsSkin conditions are common among migrant farm workers in North Carolina. The quality of housing conditions, particularly hot, dry indoor thermal environment, demonstrated significant associations with pruritus, rash, and scaling. The impact of housing characteristics on pruritus and blisters was greatest in new migrant farm workers. Further research is needed to delineate additional housing factors that could cause or exacerbate skin diseases in farm workers.
Pain and motives for use among non‐treatment seeking individuals with prescription opioid dependence
Authors: Barth Kelly S. , Maria Megan Moran‐Santa , Lawson Katie , Shaftman Stephanie , Brady Kathleen T. , Back Sudie E. 
Published: May 2013

Background and ObjectivesPatients with prescription opioid use disorders and co‐occurring pain present a formidable challenge for healthcare providers, and little is known about patients with this dual diagnosis. This study examined the prevalence of pain and motives for use among individuals with prescription opioid dependence.MethodsParticipants (N = 127) included 86 non‐treatment seeking individuals with current prescription opioid dependence and 41 healthy controls. They were administered a battery of assessments to evaluate pain and substance use.ResultsParticipants with prescription opioid dependence were significantly more likely than controls to report current pain (62.2 vs. 12.2%), as well as higher levels of pain interference and severity. The most common source of prescription opioids was a physician (91.3%) and the most common motive for using prescription opioids, initially and currently, was to relieve pain (70.3% and 81.0%, respectively). Motivation for subsequent non‐medical use of prescription opioids included to get high (73.8%), to increase energy (71.0%), to decrease anxiety (51.2%), and to improve sleep (35.7%).ConclusionPain is a significant comorbidity and motivator for the non‐medical use of prescription opioids. Provider and patient education regarding the safe use of prescription opioids, as well as interventions targeting prescription opioid dependence, are needed. (Am J Addict 2013;22:486–491)
Depression and substance abuse and dependency in relation to current smoking status and frequency of smoking among nondaily and daily smokers
Authors: Berg Carla J. , Wen Hefei , Cummings Janet R. , Ahluwalia Jasjit S. , Druss Benjamin G. 
Published: May 2013

Background and ObjectivesDaily smoking rates are decreasing while intermittent or nondaily smoking rates are increasing. Little is known about the association of depression, alcohol abuse and dependence, and illicit drug abuse and dependence with different patterns of smoking, particularly nondaily smoking. Thus, we examined these relationships among current smokers versus nonsmokers and among those who smoke daily versus less frequently.MethodsWe conducted a secondary analysis of 37,897 adults who participated in the 2008 National Survey on Drug Use and Health. We developed logistic regression models examining predictors of (i) current smoking and (ii) number of days smoking per month (1–10 days, 11–29 days, and ≥30 days) among current smokers, focusing on past‐year major depression, alcohol abuse and dependence, and illicit drug abuse and dependence.ResultsCompared to nonsmokers, current smokers more frequently reported a major depressive episode (p < .001), alcohol dependence (p < .001) and abuse (p < .001), and illicit drug dependence (p < .001) and abuse (p < .001), controlling for sociodemographics. Among current smokers, greater smoking frequency was associated with illicit drug dependence (p = .004), but lower likelihood of alcohol dependence (p = .01), alcohol abuse (p = .01), and illicit drug abuse (p = .01).ConclusionsAlthough depression and substance use were associated with greater likelihood of smoking, most measures were inversely associated with frequency of smoking. Thus, it is important to examine underlying mechanisms contributing to these counterintuitive findings in order to inform intervention approaches.Scientific SignificanceWith increased rates of nondaily smoking, developing a greater understanding about the mental health correlates related to this pattern of smoking is critical. (Am J Addict 2013;22:581–589)
PROPERTIUS 1.3: SLEEP, SURPRISE, AND CATULLUS 64
Authors: ROBINSON MATTHEW 
Published: May 2013

Abstract
Although previous scholarship has noted some verbal and stylistic allusions to Catullus in Propertius 1.3, the extent to which the poem offers a profound and detailed engagement with Catullus 64 has not been recognised. Through a close reading of the opening couplets, I hope to demonstrate the care, artistry and sophistication with which Propertius engages with Catullus 64, as he imitates and illuminates many of its key stylistic and intertextual features. I argue that this engagement with Catullus 64 is importantly programmatic, and that Propertius 1.3, like Catullus 64, is very much concerned with narrative authority and poetic control. This concern comes to the fore in Cynthia's speech at the close of the poem, and I hope to show through further close reading how its relationship to literature and art encourages us to question Propertius's portrayal of his relationship with Cynthia at this very early stage in the corpus.
Effect of Chemical and Physical Stress Conditions on the Concentration and Composition of Essential Oil Components in Leaves of Full‐Grown Artemisia annua L.
Authors: Ivarsen E. , Kjær A. , Jensen M. , Grevsen K. , Christensen L. P. , Fretté X. 
Published: May 2013

AbstractFull‐grown Artemisia annua plants were subjected to chemical and physical stress conditions, and the effect of these on the concentration and chemical composition of essential oil components (EOC) in the leaves was studied. The chemical stress treatments were performed by foliar application of NaCl, H2O2, salicylic acid and chitosan oligosaccharide (COS). The EOC of the leaves were extracted with n‐hexane and identified and quantified by GC–MS and GC–FID, respectively. Approximately 96 % of EOC in the extracts were identified and quantified of which β‐pinene, camphene, germacrene D, camphor, coumarin and dihydro‐epi‐deoxyarteannuin B were the major EOC accounting for about 75 % of the total content of EOC in the extracts. The physical stress treatment, sandblasting of the plants resulted in a significant enhancement in the content of α‐pinene, camphene, coumarin and dihydro‐epi‐deoxyarteannuin B. The total yield of identified EOC in non‐treated plants (control) was 86.2 ± 13.8 μg g−1 fresh weight (FW) compared with 104.0 ± 9.1 μg g−1 FW in sandblasted plants. The chemical stress treatments did not affect the composition of EOC significantly. The results indicate that chemical stress treatments do not affect the concentration and composition of EOC in full‐grown A. annua plants to the same extent as physical stress treatment by sandblasting.
Desiderata for a Viable Secular Humanism
Authors: Kemp Ryan 
Published: May 2013

AbstractPhilip Kitcher has recently worried that the New Atheists, by mounting an attack against religion tout court, risk alienating a large swath of ‘religious’ people whose way of life is, to Kitcher's mind, innocuous. Encouraging a more moderate response, Kitcher thinks certain non‐threatening modes of religious existence should be protected. In this article, I argue that while Kitcher's attempt to provide balance to the secularism debate is a great service, he ultimately fails to distinguish innocuous modes of religious belief from more threatening modes, a failing that allows the debate to return to its previous extremes. In drawing attention to the shortcomings of Kitcher's approach, I make the humanist's argumentative burden explicit: the defender of a ‘moderate’ secular humanism must show that people who arrange their lives around belief in a transcendent being are more likely to do ethical harm than those that don't.
“You don't expect me to believe that, do you?” Expectations influence recall and belief of alibi information
Authors: Olson Elizabeth A. 
Published: May 2013

AbstractPresumptions of guilt could bias criminal investigators' interviews of suspects, reducing recall of exculpatory alibi information, and the label “alibi” could be enough to create a presumption of guilt. Participants (n = 285) viewed a videotaped narrative account; some participants knew prior to viewing that the account was an alibi whereas others discovered this after viewing. Also, some participants were given an expectation that the alibi provider was guilty or innocent. Results indicated participants with a presumption of guilt before viewing the alibi recalled less alibi‐relevant information, found the alibi less believable, and viewed the alibi provider more negatively than did participants without such an expectation, and that a label of “alibi” was not enough to create a presumption of guilt.
Multi‐Sensor Esophageal Temperature Probe Used During Radiofrequency Ablation for Atrial Fibrillation is Associated with Increased Intraluminal Temperature Detection and Increased Risk of Esophageal Injury Compared to Single‐Sensor Probe
Authors: CARROLL BRETT J. , CONTRERAS‐VALDES FERNANDO M. , HEIST E. KEVIN , BARRETT CONOR D. , DANIK STEPHAN B. , RUSKIN JEREMY N. , MANSOUR MOUSSA 
Published: May 2013

Single vs Multi‐Sensor ETM in AF AblationBackgroundRadiofrequency (RF) ablation in the posterior left atrium has risk of thermal injury to the adjacent esophagus. Increased intraluminal esophageal temperature has been correlated with risk of esophageal injury. The objective of this study was to compare esophageal temperature monitoring (ETM) using a multi‐sensor temperature probe with 12 sensors to a single‐sensor probe during catheter ablation for atrial fibrillation (AF).Methods and ResultsWe compared the detection of intraluminal esophageal temperature rises in 543 patients undergoing RF ablation for AF with ETM. Esophageal endoscopy (EGD) was performed on all patients with maximum esophageal temperature ≥39°C. Esophageal lesions were classified by severity as mild or severe ulcerations. Four hundred fifty‐five patients underwent RF ablation with single‐sensor ETM and 88 patients with multi‐sensor ETM. Thirty‐nine percent of patients with single‐sensor versus 75% with multi‐sensor ETM reached a maximum detected esophageal temperature ≥39°C (P < 0.0001). Esophageal injury was detected by EGD in 29% of patients with maximum temperature ≥39°C by single‐sensor versus 46% of patients with multi‐sensor ETM (P = 0.021). Thirty‐nine percent of patients with lesions in the single‐sensor probe group had severe ulcerations compared to 33% of patients in the multi‐sensor probe group (P = 0.641).ConclusionsIntraluminal esophageal temperature ≥39°C is detected more frequently by the multi‐sensor temperature probe versus the single‐sensor probe, with more frequent esophageal injury and with comparable severity of injury. Despite detecting esophageal temperature rises in more patients, the multi‐sensor probe may not have any measurable benefit compared to a single‐sensor probe.
Cell adhesion and mechanical stimulation in the regulation of mesenchymal stem cell differentiation
Authors: Wang Yang‐Kao , Chen Christopher S. 
Published: May 2013

AbstractStem cells have been shown to have the potential to provide a source of cells for applications to tissue engineering and organ repair. The mechanisms that regulate stem cell fate, however, mostly remain unclear. Mesenchymal stem cells (MSCs) are multipotent progenitor cells that are isolated from bone marrow and other adult tissues, and can be differentiated into multiple cell lineages, such as bone, cartilage, fat, muscles and neurons. Although previous studies have focused intensively on the effects of chemical signals that regulate MSC commitment, the effects of physical/mechanical cues of the microenvironment on MSC fate determination have long been neglected. However, several studies provided evidence that mechanical signals, both direct and indirect, played important roles in regulating a stem cell fate. In this review, we summarize a number of recent studies on how cell adhesion and mechanical cues influence the differentiation of MSCs into specific lineages. Understanding how chemical and mechanical cues in the microenvironment orchestrate stem cell differentiation may provide new insights into ways to improve our techniques in cell therapy and organ repair.
An intensified systemic trafficking of bone marrow‐derived stem/progenitor cells in patients with pancreatic cancer
Authors: Starzyńska Teresa , Dąbkowski Krzysztof , Błogowski Wojciech , Zuba‐Surma Ewa , Budkowska Marta , Sałata Daria , Dołęgowska Barbara , Marlicz Wojciech , Lubikowski Jerzy , Ratajczak Mariusz Z. 
Published: May 2013

AbstractVarious experimental studies indicate potential involvement of bone marrow (BM)‐derived stem cells (SCs) in malignancy development and progression. In this study, we comprehensively analysed systemic trafficking of various populations of BM‐derived SCs (BMSCs), i.e., mesenchymal, haematopoietic, endothelial stem/progenitor cells (MSCs, HSCs, EPCs respectively), and of recently discovered population of very small embryonic/epiblast‐like SCs (VSELs) in pancreatic cancer patients. Circulating CD133+/Lin−/CD45−/CD34+ cells enriched for HSCs, CD105+/STRO‐1+/CD45− cells enriched for MSCs, CD34+/KDR+/CD31+/CD45− cells enriched for EPCs and small CXCR4+CD34+CD133+ subsets of Lin−CD45− cells that correspond to VSELs were enumerated and sorted from blood samples derived from 29 patients with pancreatic cancer, and 19 healthy controls. In addition, plasma levels of stromal‐derived factor‐1 (SDF‐1), growth/inhibitory factors and sphingosine‐1‐phosphate (S1P; chemoattractants for SCs), as well as, of complement cascade (CC) molecules (C3a, C5a and C5b‐9/membrane attack complex – MAC) were measured. Higher numbers of circulating VSELs and MSCs were detected in pancreatic cancer patients (P < 0.05 and 0.01 respectively). This trafficking of BMSCs was associated with significantly elevated C5a (P < 0.05) and C5b‐9/MAC (P < 0.005) levels together with S1P concentrations detected in plasma of cancer patients, and seemed to be executed in a SDF‐1 independent manner. In conclusion, we demonstrated that in patients with pancreatic cancer, intensified peripheral trafficking of selected populations of BMSCs occurs. This phenomenon seems to correlate with systemic activation of the CC, hepatocyte growth factor and S1P levels. In contrast to previous studies, we demonstrate herein that systemic SDF‐1 levels do not seem to be linked with increased mobilization of stem cells in patients with pancreatic cancer.
Up‐regulation of stomatin expression by hypoxia and glucocorticoid stabilizes membrane‐associated actin in alveolar epithelial cells
Authors: Chen Ji‐Cheng , Cai Hao‐Yu , Wang Yan , Ma Yuan‐Yuan , Song Liang‐Nian , Yin Li‐Juan , Cao Dong‐Mei , Diao Fei , Li Yi‐Dong , Lu Jian 
Published: May 2013

AbstractStomatin is an important lipid raft‐associated protein which interacts with membrane proteins and plays a role in the membrane organization. However, it is unknown whether it is involved in the response to hypoxia and glucocorticoid (GC) in alveolar epithelial cells (AEC). In this study we found that hypoxia and dexamethasone (dex), a synthetic GC not only up‐regulated the expression of stomatin alone, but also imposed additive effect on the expression of stomatin in A549 cells, primary AEC and lung of rats. Then we investigated whether hypoxia and dex transcriptionally up‐regulated the expression of stomatin by reporter gene assay, and found that dex, but not hypoxia could increase the activity of a stomatin promoter‐driven reporter gene. Further deletion and mutational studies demonstrated that a GC response element (GRE) within the promoter region mainly contributed to the induction of stomatin by dex. Moreover, we found that hypoxia exposure did not affect membrane‐associated actin, but decreased actin in cytoplasm in A549 cells. Inhibiting stomatin expression by stomatin siRNA significantly decreased dense of peripheral actin ring in hypoxia or dex treated A549 cells. Taken all together, these data indicated that dex and/or hypoxia significantly up‐regulated the expression of stomatin in vivo and in vitro, which could stabilize membrane‐associated actin in AEC. We suppose that the up‐regulation of stomatin by hypoxia and dex may enhance the barrier function of alveolar epithelia and mediate the adaptive role of GC to hypoxia.
Cultural and climatic changes shape the evolutionary history of the Uralic languages
Authors: Honkola T , Vesakoski O , Korhonen K , Lehtinen J , Syrjänen K , Wahlberg N 
Published: May 2013

AbstractQuantitative phylogenetic methods have been used to study the evolutionary relationships and divergence times of biological species, and recently, these have also been applied to linguistic data to elucidate the evolutionary history of language families. In biology, the factors driving macroevolutionary processes are assumed to be either mainly biotic (the Red Queen model) or mainly abiotic (the Court Jester model) or a combination of both. The applicability of these models is assumed to depend on the temporal and spatial scale observed as biotic factors act on species divergence faster and in smaller spatial scale than the abiotic factors. Here, we used the Uralic language family to investigate whether both ‘biotic’ interactions (i.e. cultural interactions) and abiotic changes (i.e. climatic fluctuations) are also connected to language diversification. We estimated the times of divergence using Bayesian phylogenetics with a relaxed‐clock method and related our results to climatic, historical and archaeological information. Our timing results paralleled the previous linguistic studies but suggested a later divergence of Finno‐Ugric, Finnic and Saami languages. Some of the divergences co‐occurred with climatic fluctuation and some with cultural interaction and migrations of populations. Thus, we suggest that both ‘biotic’ and abiotic factors contribute either directly or indirectly to the diversification of languages and that both models can be applied when studying language evolution.