bluuebunny/crossref_metadata_2025_split huggingface dataset:
High‐sensitive and fast MXene/silicon photodetector for single‐pixel X‐ray imaging
Authors: Chen Yance , Dai Yue , Bodepudi Srikrishna Chanakya , Liu Xinyu , Ma Yuan , Xing Shiyu , Di Dawei , Tian Feng , Ming Xin , Liu Yingjun , Pang Kai , Xue Fei , Zhang Yunyan , Yu Zexin , Dan Yaping , Penkov Oleksiy V. , Zhang Yishu , Qi Dianyu , Fang Wenzhang , Xu Yang , Gao Chao 
Published: June 2024

AbstractThe demand for high‐performance X‐ray detectors leads to material innovation for efficient photoelectric conversion and carrier transfer. However, current X‐ray detectors are often susceptible to chemical and irradiation instability, complex fabrication processes, hazardous components, and difficult compatibility. Here, we investigate a two‐dimensional (2D) material with a relatively low atomic number, Ti3C2Tx MXenes, and single crystal silicon for X‐ray detection and single‐pixel imaging (SPI). We fabricate a Ti3C2Tx MXene/Si X‐ray detector demonstrating remarkable optoelectronic performance. This detector exhibits a sensitivity of 1.2 × 107 μC Gyair−1 cm−2, a fast response speed with a rise time of 31 μs, and an incredibly low detection limit of 2.85 nGyair s−1. These superior performances are attributed to the unique charge coupling behavior under X‐ray irradiation via intrinsic polaron formation. The device remains stable even after 50 continuous hours of high‐dose X‐ray irradiation. Our device fabrication process is compatible with silicon‐based semiconductor technology. Our work suggests new directions for eco‐friendly X‐ray detectors and low‐radiation imaging system.image
Collaborative analysis of student writing: Building teacher capacity for supporting adolescent multilingual learners
Authors: Yaylali Ali 
Published: June 2024

AbstractThis conceptual article discusses a collaborative approach to building teacher capacity to support multilingual learners in secondary science classrooms. The article advocates for the collaborative analysis of student writing samples and the sharing of pedagogical insights between English language and content area teachers. Samples of student writing are analyzed situationally and linguistically to model how teachers may focus collaborative conversations on language patterns.
Examining the hepatotoxic potential of cannabidiol, cannabidiol‐containing hemp extract, and cannabinol at consumer‐relevant exposure concentrations in primary human hepatocytes
Authors: Striz Anneliese , Zhao Yang , Sepehr Estatira , Vaught Cory , Eckstrum Kirsten , Headrick Kyra , Yourick Jeffrey , Sprando Robert 
Published: June 2024

AbstractHemp extracts and consumer products containing cannabidiol (CBD) and/or other phytocannabinoids derived from hemp have entered the marketplace in recent years. CBD is an approved drug in the United States for the treatment of certain seizure disorders. While effects of CBD in the liver have been well characterized, data on the effects of other cannabinoids and hemp extracts in the liver and methods for studying these effects in vitro are limited. This study examined the hepatotoxic potential of CBD, CBD concentration‐matched hemp extract, and cannabinol (CBN), at consumer‐relevant concentrations determined by in silico modeling, in vitro using primary human hepatocytes. Primary human hepatocytes exposed to between 10‐nM and 25‐μM CBD, CBN, or hemp extract for 24 and 48 h were evaluated by measuring lactate dehydrogenase release, apoptosis, albumin secretion, urea secretion, and mitochondrial membrane potential. Cell viability was not significantly affected by CBD, CBN, or the hemp extract at any of the concentrations tested. Exposure to hemp extract induced a modest but statistically significant decrease in albumin secretion, urea secretion, and mitochondrial membrane potential at the highest concentration tested whereas CBD only induced a modest but statistically significant decrease in albumin secretion compared with vehicle control. Although this study addresses data gaps in the understanding of cannabinoid hepatoxicity in vitro, additional studies will be needed to determine how these results correlate with relevant consumer exposure and the biological effects of cannabinoids in human liver.
The relationship between financial constraints and investment efficiency
Authors: Kim Taewoo , Lee Brandon Byungwhan , Paik Daniel Gyung 
Published: June 2024

AbstractThis study examines how financial constraints relate to firm‐level investment efficiency. Prior research theorizes that corporate borrowing by issue of risky debt induces suboptimal capital investment spending. We extend this research to examine whether firm‐level financial constraints and internal investment efficiency are significantly related. We measure firms’ degree of overall financial constraint following the procedure developed by Whited and Wu. Our results indicate that among highly financially constrained firms, overall financial constraints are positively associated with investment, and higher financial constraints are more likely to result in greater investment inefficiency. Furthermore, we find that this relationship is more prominent for companies with high free cash flow, high bankruptcy likelihood, and high growth potential. Our findings that financial constraints have significant influence on corporate investment efficiency should be of interest to company managers, investors, and regulators alike.
Trade credit and corporate profitability: Evidence from EU‐based SMEs
Authors: Silva Sónia 
Published: June 2024

AbstractThis study provides empirical evidence about the impact of granting trade credit to customers on the profitability of EU‐based SMEs over 2012–2019. Results show an inverted U‐shaped relationship between corporate performance and trade credit – proxied by receivables, meaning a positive relationship between creditors and customers for low levels and a negative relationship for high levels of trade credit. This evidence is concentrated on firms with less financial flexibility, for which any deviation from the maximum point of investment in trade credit represents a negative impact on its performance due to payment delay or even a default event. Results are robust to potential endogeneity issues.
The Role and Clinical Relevance of Glycolysis‐Associated Genes on Immune Infiltration in Hepatocellular Carcinoma
Authors: Li Jing , Su Peng , Li Ting , Hao Yang , Wang Tianjun , Fu Lei , Liu Xin 
Published: June 2024

ABSTRACTHepatocellular carcinoma (HCC) poses a significant challenge with dismal survival rates, necessitating a deeper understanding of its molecular mechanisms and the development of improved therapies. Metabolic reprogramming, particularly heightened glycolysis, plays a crucial role in HCC progression. Glycolysis‐associated genes (GAGs) emerge as key players in HCC pathogenesis, influencing the tumor microenvironment and immune responses. This study aims to investigate the intricate interplay between GAGs and the immune landscape within HCC, offering valuable insights into potential prognostic markers and therapeutic targets to enhance treatment strategies and patient outcomes. Through the exploration of GAGs, we have identified two distinct molecular glycolytic subtypes in HCC patients, each exhibiting significant differences in both the immune microenvironment and prognosis. A risk model comprising five key GAGs was formulated and subsequently evaluated for their predictive accuracy. Our findings underscore the diverse tumor microenvironment and immune responses associated with the varying glycolytic subtypes observed in HCC. The identified key GAGs hold promise as prognostic indicators for evaluating HCC risk levels, predicting patient outcomes, and guiding clinical treatment decisions, particularly in the context of anticipating responses to immunotherapy drugs.
Deciphering the energy storage and electro‐catalytic potential of the BaLa2MnS5 ternary metallic sulfide prepared via single source precursor route
Authors: Jaffri Shaan Bibi , Ahmad Khuram Shahzad , Lin Wang , Gupta Ram K. , Ashraf Ghulam Abbas , Alothman Asma A. 
Published: June 2024

AbstractThe present work elucidates the first report on the synthesis and energy applications of the novel BaLa2MnS5 prepared from single source precursor route. This metal chalcogenide expressed a tuned band gap of 3.84 eV and an average crystallite size of 20.52 nm. Functional groups explored for BaLa2MnS5 expressed strong signals for presence of the metal sulfide bonds. The thermal decomposition pattern of BaLa2MnS5 followed a two‐phased mechanism. Synthesized metal sulfide possessed an irregular morphology with particles arranged in random manner. An assessment of the chalcogenide BaLa2MnS5 for energy applications has been carried out. When employed as an electrode material in 1 M KOH, which acted as the background electrolyte, BaLa2MnS5 chalcogenide showed a specific capacitance of 597 F g−1. Furthermore, this BaLa2MnS5 chalcogenide decorated electrode has a low resistance, as shown by the Rs of 1.35 Ω, and a specific power density of 7366 W kg−1, according to the impedance investigations. The electrochemical results for the OER activity are indicative of the OER overpotential and Tafel slope values as 388 mV and 108 mV/dec. This electrode achieved the HER overpotential value of 241 mV while the obtained Tafel slope was 194 mV/dec.
Importance of CD71+ Erythrocyte Cell Levels in Prognosis in Patients With β‐Thalassemia
Authors: Görgülügil Gizem Zorlu , Uğur Kurtoğlu Ayşegül , Uğur Sevcan , Kurtoğlu Erdal 
Published: June 2024

ABSTRACTBackground/ObjectivesCD71+ erythroid cells (CECs) are immature red blood cells (proerythroblasts, erythroblasts, and reticulocytes). CECs play an important role in the development of sepsis and cancer by causing immunosuppression. We examined the CEC levels in the peripheral blood of beta thalassemia (βThal) patients and investigated the relationship between CECs and the clinical status of the patients, especially splenectomy.MethodsSixty‐eight patients with βThal (46 splenectomized and 22 nonsplenectomized) and 15 healthy controls were included in this study. The hemogram parameters, ferritin, and CECs (flow cytometry method) were measured.ResultsIt was observed that the CEC level in the patient group was significantly higher than the control group (p < 0.05). CEC levels were found to be significantly higher in patients with splenectomy than in patients with nonsplenectomy (p < 0.05). CEC levels were higher in patients with nontransfusion‐dependent βT (NTD‐βThal) than in patients with transfusion‐dependent βT (TD‐βThal) (p < 0.05). CEC levels were found to be significantly higher in patients with splenectomy than in patients with nonsplenectomy in both TD‐βThal and NTD‐βThal groups (p < 0.05). There was a moderate‐negative correlation was detected between CECs and Hb levels (r = −0.467; p < 0.05).ConclusionsHigh CEC levels in βThal patients develop as a result of ineffective erythropoiesis. We think that keeping CEC levels under control is important for prognosis, especially in patients with splenectomy.
Pharmacotherapy of Weight‐loss and Obesity with a Focus on GLP 1‐Receptor Agonists
Authors: Myerson Merle , Paparodis Rodis D. 
Published: June 2024

AbstractObesity is a disease of epidemic proportions in the United States and contributes to morbidity and mortality for a large part of the population. In addition, the financial costs of this disease to society are high. Lifestyle modifications are key to prevention and treatment but adherence and long‐term success have been challenging. Bariatric surgery has been available and pharmacologic approaches, first developed in the 1950s, continue to be an option; however, existing formulations have not provided optimal clinical efficacy and have had many concerning adverse effects. Over the last decade, glucagon‐like peptide‐1 (GLP‐1) receptor agonists, a novel group of medications for the treatment of type 2 diabetes, were found to produce significant weight loss. Several formulations, at higher doses, received FDA approval for the treatment of obesity or those overweight with weight‐related co‐morbidities. More hormone‐based therapies were and are being developed, some with dual or triple‐receptor agonist activity. Their use, however, is not without questions and concerns as to long‐term safety and efficacy, problems with cost and reimbursement, and how their use may intersect with public health efforts to manage the obesity epidemic. This review will focus on the GLP‐1 receptor agonists currently used for weight loss and discuss their pharmacology, pertinent research findings establishing their benefits and risks, issues with prescribing these medications, and a perspective from a public health point of view.
The value of stereoscopic three‐dimensional vision on dental students’ performance in a virtual reality simulator
Authors: Al Ali Huda , Nassief Sarah , Towers Ashley , Field James , Martin Nicolas 
Published: June 2024

AbstractPurpose/objectivesThe aim of this study was to quantitatively investigate the impact of stereoscopic three‐dimensional (3D) vision on students’ performance when compared with that of two‐dimensional (2D) vision in a 3D virtual reality (VR) simulator.MethodsTwenty‐four dental students (second‐ and fourth‐year BDS) were assigned to perform three operative tasks under 3D and 2D viewing conditions on a Virteasy (HRV) simulator. Groups were crossed over and all students performed the same tasks under the alternate viewing conditions. The performance was evaluated by (1) accuracy, (2) outside target area removal, and (3) tooth cutting time, automatically using the generated feedback.ResultsTwenty‐one participants completed all sessions. The results revealed a statistically significant effect of 3D vision over 2D vision on students’ performance in terms of accuracy (p = 0.035). Stereoscopic 3D vision showed significant effect on outside target area removal in the first task (p = 0.035). Tooth cutting time was the same under both conditions (p = 0.766). The findings revealed improvement in accuracy score and reduction in outside target area removal over the course of the experiment under both conditions. Comparing the difference in 3D effect in the early and advanced learning groups revealed no significant difference among the groups (p > 0.05).ConclusionUtilizing stereoscopic 3D vision in the training session improved students’ perception of depth which led to more accurate tooth cutting within the target area, and less outside target area removal. However, 3D shows a limited impact on task completion time.
Attachment and meaning‐making of Arabic mothers during the coronavirus pandemic
Authors: Ghoston Michelle R. , Alwahibah Salma O. , Alkusayer Asma Tawfik , Fetyani Lolwa , Alnashmi Fai , Field Thomas A. 
Published: June 2024

AbstractThe global impact of COVID‐19 heightened existential awareness particularly among parents. This period provided a unique opportunity to implement the circle of security program, equipping parents to address parental stress, anxiety, and depression. Conducted with mothers in Saudi Arabia ranging in age from 19 to 30 years, this quasi‐experimental intervention study demonstrated a notable reduction in negative emotions, coupled with enhanced parent–child relationships and a strengthened sense of purpose in parenting. A total of 70 (55%) mothers attended at least 6 of 8 sessions, the criteria for completer status. After the intervention, there was a significant improvement in mental health, as the majority of participants fell within the normal ranges for anxiety (91.4%), depression (95.7%), and stress (95.7%). Furthermore, statistical evaluations provided strong evidence of the intervention's success, demonstrating a significant reduction in mean anxiety scores from 4.44 ± 3.88 to 2.8 ± 2.01 (p = 0.08), depression scores from 6.2 ± 5.0 to 3.54 ± 2.5 (p < 0.001), and stress scores from 9.29 ± 4.45 to 4.9 ± 4.5 (p < 0.001). These findings underscore the importance of interventions supporting parents during challenging times, such as a global pandemic.
Association between malnutrition and post–acute COVID‐19 sequelae: A retrospective cohort study
Authors: Ponce Jana , Anzalone A. Jerrod , Schissel Makayla , Bailey Kristina , Sayles Harlan , Timmerman Megan , Jackson Mariah , Tefft Jonathan , Hanson Corrine ,   the National COVID Cohort Collaborative (N3C) Consortium
Published: June 2024

AbstractBackgroundLong coronavirus disease consists of health problems people experience after being infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). These can be severe and include respiratory, neurological, and gastrointestinal symptoms, with resulting detrimental impacts on quality of life. Although malnutrition has been shown to increase risk of severe disease and death during acute infection, less is known about its influence on post–acute COVID‐19 outcomes. We addressed this critical gap in knowledge by evaluating malnutrition's impact on post–COVID‐19 sequelae.MethodsThis study leveraged the National COVID Cohort Collaborative to identify a cohort of patients who were at least 28 days post–acute COVID‐19 infection. Multivariable Cox proportional hazard models evaluated the impact of malnutrition on the following postacute sequelae of SARS‐CoV‐2: (1) death, (2) long COVID diagnosis, (3) COVID‐19 reinfection, and (4) other phenotypic abnormalities. A subgroup analysis evaluated these outcomes in a cohort of hospitalized patients with COVID‐19 with hospital‐acquired (HAC) malnutrition.ResultsThe final cohort included 4,372,722 individuals, 78,782 (1.8%) with a history of malnutrition. Individuals with malnutrition had a higher risk of death (adjusted hazard ratio [aHR]: 2.10; 95% CI: 2.04–2.17) and SARS‐CoV‐2 reinfection (aHR: 1.52; 95% CI: 1.43–1.61) in the postacute period than those without malnutrition. In the subgroup, those with HAC malnutrition had a higher risk of death and long COVID diagnosis.ConclusionNutrition screening for individuals with acute SARS‐CoV‐2 infection may be a crucial step in mitigating life‐altering, negative postacute outcomes through early identification and intervention of patients with malnutrition.
Preloading peri‐implant crestal bone loss: A retrospective study of incidence and related factors
Authors: Vilela Nathalia , Gurgel Bruno C. V. , Bruzos Carlos De , Duarte Wagner R. , da Silva Hélio D. P. , Pannuti Claudio M. , Duarte Poliana Mendes 
Published: June 2024

AbstractBackgroundThe aim of this study was to evaluate the incidence of preloading crestal bone loss (PLCBL) and to identify the patient‐related and implant‐related factors associated with PLCBL.MethodsThis retrospective cohort examined the dental records of patients who received at least one dental implant. PLCBL was defined as a reduction ⩾0.5 mm and severe PLCBL (primary variable) as a reduction ⩾1.5 mm in mesial and/or distal bone level, measured from the day of implant placement to uncovering or abutment installation/crown delivery. The incidence of PLCBL and patient and implant variables were recorded. Bivariate analysis and binary logistic regression identified factors associated with PLCBL ⩾0.5 mm and ⩾1.5 mm.ResultsA total of 746 dental implants placed in 361 patients from January 2011 to July 2021 was included in the analyses. Of the implants assessed, 24.4% (n = 182) exhibited PLCBL ⩾ 0.5 mm and 10.5% (n = 78) presented severe PLCBL (i.e., ⩾1.5 mm). Males (odds ratio [OR] = 1.85, 95% confidence interval [CI] = 1.11–3.07), patients with diabetes (OR = 3.33, 95% CI = 1.73–6.42), and those allergic to penicillin (OR = 3.13, 95% CI = 1.57–6.22) were more likely to experience severe PLCBL (p < 0.05). Implants placed in the anterior area (OR = 2.08, 95% CI = 1.16–3.73), with bone‐level platform‐abutment connection (OR = 4.73, 95% CI = 1.94–11.49) and inserted supracrestally (OR = 3.77, 95% CI = 1.84–7.72), presented a greater risk of developing severe PLCBL (p < 0.05). Implants placed in a previously grafted area presented a lower likelihood of developing severe PLCBL (OR = 0.489, 95% CI = 0.28–0.84).ConclusionThe incidence of PLCBL ⩾ 0.5 mm and ⩾1.5 mm was 24.4% and 10.5%, respectively. Male sex, diabetes, allergy to penicillin, anterior location, bone‐level platform‐abutment connection, and supracrestal implant placement are potential risk factors for severe PLCBL. A previously grafted area is a potential protective factor.
Raman study of the conformational instability of a ferrocene molecule at high pressure: Influence of a crystal field
Authors: Meletov Konstantin 
Published: June 2024

AbstractThe Raman spectra of ferrocene crystals were measured at pressures up to 20 GPa, and an abnormally large bandwidth of intermolecular phonons at ambient pressure was found. With an increase in the pressure, the bandwidth increased to a maximum at ~2 GPa and then decreased to a minimum at ~4 GPa, which was equal to the pressure‐independent bandwidth of intramolecular phonons. The unusual behavior of the bandwidth was related to the instability of a ferrocene molecule caused by jumps between its D5d and D5h conformations. A decrease in the time of jumps between the conformations to the period of crystal lattice vibrations led to a loss of coherence and broadening of intermolecular phonon bands. The energy barrier between the conformations was determined to be ~17.6 meV/molecule under ambient conditions and 80 meV/molecule at 4.9 GPa. An increase in the barrier with pressure was due to the enhancement of the crystal field, which resulted in the inhibition of the jumps and the stabilization of the molecule in the D5d conformation.
Entrepreneurs' use of imagination in pivot decision: Toward a conceptual model
Authors: Gabay‐Mariani Laëtitia , Flechas Ximena Alejandra , Blank Tali Hadasa 
Published: June 2024

AbstractThe purpose of the paper is to open the black box of pivot decisions and to deepen our understanding of how entrepreneurs use their imagination in such a crucial moment of the entrepreneurial process. A pivot is a strategic decision made after a failure and challenges central assumptions about the entrepreneurial project. In turn, entrepreneurs can remain quite conservative in the generation of new options for their business and expose themselves to the risks of path dependency and escalation of commitment. Reconfiguring an initial idea requires specific cognitive skills and mechanisms. In this paper, we sketch a conceptual model explaining the relationships between creative, social, and practical imaginativeness and the generation of new business options, and how founders' cognitive mechanisms may moderate this relationship.