bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract B23: Colombians with high percentage of African ancestry, carrying a specific IL1B haplotype, have increased risk of colorectal cancer
Authors: Sanabria-Salas Maria Carolina , Hernandez-Suarez Gustavo , Umaña-Perez Adriana , Serrano-Lopez Martha Lucia , Sanchez-Gomez Myriam , Rojas Martha Patricia , Zabaleta Jovanny 
Published: May 2015

Abstract
Background: Colorectal cancer mortality rates are heterogeneous across Colombian territory and this variation could be explained by regional differences in Colombian ethnicity due to our high population admixture. Different frequencies of the interleukin 1 beta (IL1B) genetic variations have been described among diverse ethnical groups, but there are no reports on the possible association of these variants with colorectal cancer (CRC) risk as an effect of the genetic population dynamics in Colombia.
Methods: To evaluate the association of IL1B haplotypes with colorectal carcinogenesis, we genotyped 317 CRC cases, 199 adenomatous polyps (AP) and 511 age-sex matched controls recruited from six Colombian cities located either on the coastal or the inner zone of the country. Five IL1B SNPs (-3737, -1464, -511, -31 and +3954) were genotyped and all were in HWE (p&gt;0.05). We used data from previous analysis to estimate individual ancestral genetic fractions using STRUCTURE software based on allele frequencies of 678 autosomal SNPs cross-matched with the HapMap dataset, not in LD, and assuming three distinct population origins (CEU, LWJ and CHB populations) from HapMap project as references.
Results: We found a 4-SNPs haplotype block (-3737C/-1464G/-511T/-31C) with high LD associated with CRC risk. Additional analysis revealed that this association persisted after adjusting by confounding variables including ancestry information (OR 1.95; CI 1.12 - 3.38; p =0.02). Interestingly, this association was evident among individuals from the coastal zone of the country and it was related with their higher African ancestry fraction (OR 2.26; 95%CI 1.22-4.18; p =0.01). Our results are in agreement with previous reports showing that this haplotype increase the IL1B promoter activity and that is highly prevalent in African-Americans.
Conclusions: To the best of our knowledge, this is the first study seeking for the association between CRC risk and IL1B gene in a haplotype context in a population-based association study in Colombia, an admixed population. Our results represent consistent evidence on how the identification of genetic biomarkers of susceptibility could be used to discriminate populations at increased risk of CRC development.
Citation Format: Maria Carolina Sanabria-Salas, Gustavo Hernandez-Suarez, Adriana Umaña-Perez, Martha Lucia Serrano-Lopez, Myriam Sanchez-Gomez, Martha Patricia Rojas, Jovanny Zabaleta. Colombians with high percentage of African ancestry, carrying a specific IL1B haplotype, have increased risk of colorectal cancer. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr B23. doi:10.1158/1538-7755.DISP13-B23
Abstract B32: Heterogeneity of breast cancer clinical characteristics and outcomes in U.S. black women - effect of place of birth
Authors: Camacho-Rivera Marlene , Kalwar Tricia , Sanmugarajah Jasotha , Shapira Iuliana , Taioli Emanuela 
Published: May 2015

Abstract
Background: Breast cancer mortality in black women is disproportionately high; reasons for this phenomenon are still unclear. In addition to socioeconomic factors, the biology of the tumor may play a role.
Methods: We analyzed 1,097 incident invasive breast cancer cases diagnosed between 2000 and 2010 in black US women from Long Island and Brooklyn. Kaplan-Meier curves were calculated and fitted for cancer mortality; when data were stratified, the log-rank test was used to assess statistical differences in survival across strata. A multivariable Cox hazard model was applied to assess the independent contributions to survival of several factors such as age, histology, stage at diagnosis, and hormone receptor status.
Results: Thirty-five percent of women had an estrogen receptor (ER) negative tumor, 46% a progesterone receptor (PR) negative tumor. ER, PR negative tumors were diagnosed at an earlier age (55.8 vs 55.3 yrs), at a later stage (p= 0.06), were larger in size (p=0.04), and more frequently treated with neoadjuvant chemotherapy (p=0.06) than ER, PR positive tumors. Determinants of shorter survival were: ER, PR negativity (HR: 2.2, 95% CI: 1.4-3.4), age, and stage at diagnosis (HR: 2.0; 95% CI: 1.5-2.7). ER, PR negative women born outside of the US experienced significantly worse survival than ER, PR negative women who were born in the US. There were no differences in survival based on therapeutic strategy (radiation, chemotherapy, or surgery).
Conclusions: ER, PR negative tumors in black women born outside the US, mainly in the Caribbean, are biologically more aggressive than the same tumor size and age matched tumors in black women born in the US. Our study suggests that environmental exposures in the country of origin may impact on host cancer interactions and cancer outcome.
Citation Format: Marlene Camacho-Rivera, Tricia Kalwar, Jasotha Sanmugarajah, Iuliana Shapira, Emanuela Taioli. Heterogeneity of breast cancer clinical characteristics and outcomes in U.S. black women - effect of place of birth. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr B32. doi:10.1158/1538-7755.DISP13-B32
Abstract B39: Clinical characteristics of breast cancers in African American women with benign breast disease: A comparison to the Surveillance, Epidemiology and End Results Program
Authors: Mitro Susanna D. , Ali-Fehmi Rouba , Bandyopadhyay Sudeshna , Alosh Baraa , Albashiti Bassam , Ahmed Quratulain , Radisky Derek C. , Frost Marlene H. , Degnim Amy C. , Ruterbusch Julie J. , Cote Michele L. 
Published: May 2015

Abstract
Although the association between benign breast disease (BBD) and risk of subsequent breast cancer is well-established, no previous studies have compared characteristics of breast cancers in women with a history of BBD to characteristics of cancers in the general population. In this study, we compared the characteristics of 109 breast cancers that developed in a population of African-American women with a history of benign breast disease (BBD population) to 10,601 breast cancers that developed in a general population of African-American women whose cancers were recorded by the Metropolitan Detroit Cancer Surveillance System (MDCSS population). The populations were compared on demographic characteristics such as age, marital status, and previous cancers, as well as clinical characteristics such as tumor hormone receptor status, grade, stage, behavior, size, and treatment. Overall and breast cancer-specific survival were also compared between populations. Women in the BBD population developed lower grade, earlier stage cancers that were more likely to be hormone receptor-positive and less likely to exhibit invasive behavior. Women in the BBD population were also significantly less likely to die from breast cancer after ten years of follow-up. These results suggest that although women with a history of BBD are at greater breast cancer risk, their breast cancers may be more likely to be detected early, leading to better breast cancer-specific survival.
Citation Format: Susanna D. Mitro, Rouba Ali-Fehmi, Sudeshna Bandyopadhyay, Baraa Alosh, Bassam Albashiti, Quratulain Ahmed, Derek C. Radisky, Marlene H. Frost, Amy C. Degnim, Julie J. Ruterbusch, Michele L. Cote. Clinical characteristics of breast cancers in African American women with benign breast disease: A comparison to the Surveillance, Epidemiology and End Results Program. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr B39. doi:10.1158/1538-7755.DISP13-B39
Abstract B48: Gastric cancer presentation and survival among California Asians
Authors: Barzi Afsaneh , Stern Mariana , Zhang Juanjuan , Deapen Dennis , Liu Lihua 
Published: May 2015

Abstract
Gastric cancer (GC) is the 4th cause of cancer death worldwide. In the US, GC results in more than 10,000 cancer related deaths annually. Furthermore, it is associated with significant morbidity in the affected individuals. The disease has a high incidence in Asian and Hispanic population. In the US, California has the highest number of GC cases per year, possibly due to high number of Asian and Hispanic population. We designed a study to explore the disparities in the presentation and outcome of GC in the Asian population.
Using data from the California Cancer Registry (CCR), we investigated the GC incidence and survival rates among Asians in California from 2000-2010. We explored the significance of demographics in the anatomic presentation of gastric cancer and survival in the Asian population compared to non-Hispanic Whites (NHW). We identified 18,377 GC cases (inclusive of NHW and Asians) in this time period. In this population 70% were NHW, 8% Chinese, 7% Korean and 5% Japanese, the rest included Filipino, Vietnamese and other Asian sub-groups.
Koreans have the highest age adjusted incidence rate of GC compared to NHW and all other Asian groups. Moreover, the frequencies of stomach cancer by anatomical subsites were statistically significantly different between Asians and NWH for both males and females (p&lt;0.001). Compared to NHW, Asians had lower frequency of proximal (cardia and fundus) stomach cancer (44% in NHW and 14% in Asians). The difference was more dramatic in Korean population than other groups (only 7% had proximal cancers).
Despite higher incidence, Koreans have better survival than NHW when adjusted for age, gender, SES, nativity, stage, anatomical subsite, and type of treatment received. Prognostic factors for death from gastric cancer included age &gt; 65 and immigration status, with immigrants doing better than US born.
The differences in the anatomical distribution of GC and outcome in the Asian population may be due to differences in etiologic factors that deserve further exploration. In Japan and Korea, early detection had resulted in a dramatic decline in mortality and morbidity. Although overall low incidence of the disease in US is prohibitive for a generalized screening program, there are subpopulations that may benefit from screening. Given that early detection has proven to be effective and cost saving in Asian countries with high incidence of gastric cancer consideration of screening for this population is intriguing and should be explored.
Citation Format: Afsaneh Barzi, Mariana Stern, Juanjuan Zhang, Dennis Deapen, Lihua Liu. Gastric cancer presentation and survival among California Asians. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr B48. doi:10.1158/1538-7755.DISP13-B48
Abstract B49: Androgen receptor CAG repeat length association with prostate cancer risk in obese and non-obese African American men
Authors: Chornokur Ganna , Amankwah Ernest K. , Park Jong Y. , Phelan Catherine M. , Powsang Julio , Kumar Nagi B. 
Published: May 2015

Abstract
Background. Prostate cancer (PCa) racial disparity is likely to be multifactorial, involving the individual's genotype, the environment and their interaction. The trinucleotide (CAG)(n) repeat polymorphism in exon 1 of the androgen receptor (AR) gene regulates AR activity, with longer alleles conferring reduced activity. Significant interethnic variations in the allele frequencies of the AR (CAG)(n) polymorphism have been reported. We investigated the association between the AR CAG(n) repeat length and PCa risk in African American (AA) and Non-Hispanic White (NHW) men. We further explored if this association varied by body mass index (BMI) in the two races.
Methods. We tested DNA samples from 259 (136 cases and 123 controls) AA and 269 (147 cases and 142 controls) NHW men, matched by age, Gleason score and PSA. The CAG repeat region was PCR amplified, and the PCR fragments were analyzed using the Beckman Coulter CEQ8000 DNA sequencer to establish the repeat length. Associations between repeats and PCa risk were evaluated using unconditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for each race. Repeats were categorized using the median (22 repeats) as a cutpoint.
Results. AA men with longer AR CAG repeats (≥22) had a statistically significantly increased PCa risk, compared to AA men with shorter (&lt;22) repeats (OR=1.81; 95%CI=1.05-3.13; P=0.034). The association was further evident among obese AA men (BMI≥30) (OR=3.12; 95%CI=1.12-8.73; P=0.03), but not in non-obese AA men (BMI&lt;30) (OR=1.43; 95%CI=0.73-2.77; P=0.30). No associations were observed between short or long AR CAG repeats and PCa risk among NHW men, regardless of BMI status.
Conclusions. Our results suggest that PCa risk may be increased among AA men with longer AR CAG repeats (≥22), especially obese (BMI≥30) AA men. The data provide evidence for ethnic differences in androgenic pathway activity and androgen sensitivity which may contribute to PCa disparity.
Citation Format: Ganna Chornokur, Ernest K. Amankwah, Jong Y. Park, Catherine M. Phelan, Julio Powsang, Nagi B. Kumar. Androgen receptor CAG repeat length association with prostate cancer risk in obese and non-obese African American men. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr B49. doi:10.1158/1538-7755.DISP13-B49
Abstract B53: A case study on differences on cervical cancer screening knowledge and prevention practices among Latinas at two sites in a community-based participatory randomized control trial in South Florida
Authors: Rodriguez Brendaly , Carrasquillo Olveen , Kobetz Erin , Gonzalez Martha , Koru-Sengal Tulay , Miao Feng , McCann Shelia , Amofah Anthony , Frett Brigitte 
Published: May 2015

Abstract
Immigrant Latinas are less likely to be screened for cervical cancer. With National Cancer Institute (NCI) support, we are examining the effectiveness of community health workers (CHWs) at increasing cervical cancer screening using self-sampling for the Human Papilloma virus (HPV, done free) versus clinic referral for traditional Pap Smear screening (nominal co-payments). Out of 455 participants enrolled to date, one site (Hialeah) serves mostly Cuban women (N=152) and the other site (Southern Miami-Dade County, SMD) serves a predominantly non-Cuban Latino population (N=112 plus 39 non Hispanic). Using a mixed methods quantitative/qualitative approach, we examined differences in demographics, cervical cancer knowledge and prevention practices among participants at these sites. Latino participants in Hialeah were younger, more recent immigrants, more educated, insured, higher literacy (SAHLSA), and higher cervical cancer knowledge that those in SMD. Most participants in Hialeah (95%) preferred HPV self-sampling citing familiarity with home based vaginal screening in Cuba and preferences for health services that were free as main reason for choosing HPV self-sampling. In SMD only half the population chose the HPV self-sampler. Cultural discomfort with vaginal self-sampling, preference for a doctor to perform a vaginal exam, and greater willingness to pay for health care services (despite lower SES) were found be major reasons why many women in SMD preferred being referred to a clinic for a traditional Pap smear. This study again highlights major differences in health knowledge and behaviors among different Latino subgroups. It also emphasizes the need for community based health programs to be tailored to the specific needs and practices of distinct Latino communities.
Citation Format: Brendaly Rodriguez, Olveen Carrasquillo, Erin Kobetz, Martha Gonzalez, Tulay Koru-Sengal, Feng Miao, Shelia McCann, Anthony Amofah, Brigitte Frett. A case study on differences on cervical cancer screening knowledge and prevention practices among Latinas at two sites in a community-based participatory randomized control trial in South Florida. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr B53. doi:10.1158/1538-7755.DISP13-B53
Abstract B56: Prostate cancer knowledge, myths, and misconceptions among Haitian men
Authors: Moline Olivia M. 
Published: May 2015

Abstract
Similar to other Black men, Haitian men are at risk for prostate cancer. However, little is known about prostate cancer in Haitian American men. To address this gap in the literature, the purpose of this study was to assess the prostate cancer knowledge and misconceptions of Haitian American men. The research questions were: (1) What is the level of prostate cancer knowledge among Haitian men? (2) What are the common myths and misconceptions associated with prostate cancer among Haitian men? (3) Which demographic factors are associated with prostate cancer knowledge, myths, and misconceptions? The inclusion criteria for participants were men of Haitian ancestry, 40 – 70 years old, with ability to speak, read and write in English. Data collection took place in Orlando and Miami (Florida); and was by self-administered survey. A total of 95 men were recruited during two health forums and at a church. T-shirts or a bag was provided as incentives for participation in the study. Descriptive analyses and simple regression was employed to analyze the data. Prostate cancer knowledge was found to be low among the participants. In addition, prostate cancer myths and misconceptions was low.
Citation Format: Olivia M. Moline. Prostate cancer knowledge, myths, and misconceptions among Haitian men. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr B56. doi:10.1158/1538-7755.DISP13-B56
Abstract B94: Examining the process of patient navigation for screening colonoscopy among African American and Latinos
Authors: Sly Jamilia , Pelto Debra , Winkel Gary , Thompson Hayley , Redd William , Itzkowitz Steven , Jandorf Lina 
Published: May 2015

Abstract
Patient Navigation (PN) reduces many of the barriers to successful completion of screening colonoscopy. To optimize the efficiency of PN and further reduce racial and ethnic disparities in cancer incidence and mortality, it is important to examine associations between the process of patient navigation and screening colonoscopy completion. The objectives of this study were to assess the amount of time patient navigators spent contacting and communicating with minority participants and to determine whether the number of calls and contact time predict completion of screening colonoscopy. In the context of a prospective, randomized controlled trial of PN for screening colonoscopy conducted in New York City from 2007-2012 among African Americans and Latinos, participants received three scripted telephone calls from a navigator during which the appointment was scheduled and bowel preparation instructions, transportation needs, health education regarding colorectal cancer and screening, and support were discussed. African American and Latino participants (N=742) at least 50 years old referred for screening colonoscopy received either culturally-targeted PN or standard PN (no differences in study arms were detected). Call logs documented the number of calls each participant received as well as the length of each phone call. Socio-demographic characteristics were also assessed. Completion of Call 2 and 3 were the strongest predictors of screening colonoscopy completion. Participants who spent less time on Call 1, more time on Calls 2 and 3 and who had fewer Call 1 attempts were also more likely to complete a screening colonoscopy. Completion of colonoscopy may be predicted from the length of time PNs spend with patients during the first and third telephone calls. This information could improve the efficacy of patient navigation programs for screening colonoscopy among minorities and provides further support for the effectiveness of patient navigation as a strategy to reduce cancer screening disparities.
Citation Format: Jamilia Sly, Debra Pelto, Gary Winkel, Hayley Thompson, William Redd, Steven Itzkowitz, Lina Jandorf. Examining the process of patient navigation for screening colonoscopy among African American and Latinos. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr B94. doi:10.1158/1538-7755.DISP13-B94
Abstract C03: Disparitome-Miner: A data visualization web-application for ‘gene-of-interest’ in health disparities
Authors: Madamanchi Aasakiran , Cappel David , Madamanchi Chaitanya , Covarrubias Roman , Thomson John Micheal 
Published: May 2015

Abstract
Attempting to understand the gene-environment interactions that lead to disease is the basis of modern molecular medicine. DNA microarray technology has provided vast quantities of new data for building up these models. Unfortunately the vast majority of studies using this technology consist of samples from populations of European ancestry. To understand the gene-environment interactions that contribute to racial and ethnic health disparities data from studies with samples from diverse populations must be analyzed.
Currently, this data is limited and hard to access. The few studies that use samples from diverse populations are lost among the millions of published microarray datasets. To address this issue we have developed Disparitome-Miner, a microarray database and web-based data-mining platform that will serve as a tool for facilitating discovery from published transcriptomic datasets. To date, Disparitome-Miner contains 18 microarray datasets consisting of samples from diverse patient populations. Differential expression analyses comparing tissue samples from healthy and disease states in multiple ancestry backgrounds are provided. Transcriptomic microarray data is analyzed and visualized interactively through Shiny Server, an open-source package for web-based R applications. Our hope is that Disparitome-Miner allows life scientists without advanced statistical training to evaluate their gene-of-interest for a role in the gene-environment interactions that contribute to racial and ethnic health disparities. This web-app can provide help in hypothesis-generation and facilitate further investigation into health disparities.
Citation Format: Aasakiran Madamanchi, David Cappel, Chaitanya Madamanchi, Roman Covarrubias, John Micheal Thomson. Disparitome-Miner: A data visualization web-application for ‘gene-of-interest’ in health disparities. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr C03. doi:10.1158/1538-7755.DISP13-C03