bluuebunny/crossref_metadata_2025_split huggingface dataset:
New analyses of the sensory organization test compared to the clinical test of sensory integration and balance in patients with benign paroxysmal positional vertigo
Authors: Mulavara Ajitkumar P. , Cohen Helen S. , Peters Brian T. , Sangi‐Haghpeykar Haleh , Bloomberg Jacob J. 
Published: April 2013

Objectives/HypothesisTo determine whether the Sensory Organization Test (SOT) of the computerized dynamic posturography battery or the Clinical Test of Sensory Integration and Balance (CTSIB) is more likely to indicate balance disorders in people with benign paroxysmal positional vertigo (BPPV).Study DesignNormal controls were compared to patients with unilateral BPPV of the posterior semicircular canal.MethodsSubjects performed tests with eyes open or closed on stable and unstable surfaces, with head still or with head moving at 0.33 Hz in pitch or yaw. Dependent variables were the percent time of the standard duration each subject could perform the task, the number of head motions made, and kinematic variables measured with head‐ and torso‐mounted inertial motion units.ResultsBecause equilibrium scores of control subjects improved significantly over repeated trials on SOT, patients were given only one trial per condition. For percent time between‐group differences were found on CTSIB with eyes closed, on foam, head moving in yaw showing significantly reduced performance by BPPV subjects compared to controls. Compared to controls, patients made significantly fewer head movements on CTSIB, eyes closed, on foam, head still, in pitch and yaw. Kinematic data also differed between the groups on tests with eyes closed and unstable surfaces with different head movement combinations, indicating increased instability in BPPV patients.ConclusionsFor screening, CTSIB with head movements is more likely than SOT to indicate balance deficits, especially when dependent measures include percent time as well as head movement counts and kinematic measures.Level of Evidence3b. Laryngoscope, 123:2276–2280, 2013
Outcome predictors in squamous cell carcinoma of the maxillary alveolus and hard palate
Authors: Eskander Antoine , Givi Babak , Gullane Patrick J. , Irish Jonathan , Brown Dale , Gilbert Ralph W. , Hope Andrew , Weinreb Ilan , Xu Wei , Goldstein David P. 
Published: April 2013

Objectives/HypothesisHard palate and maxillary alveolus are two commonly grouped oral cavity subsites due to their anatomic contiguity and oncologic disease behavior. Few studies have been conducted investigating clinical presentation, staging, prevalence of cervical metastases, and outcomes in this population. The primary objective of this study was to analyze predictors of disease‐free survival (DFS) in surgically treated patients, particularly as it relates to the role of neck dissection.Study DesignCohort study with planned data collection.MethodsThis cohort study used planned data collection over 15 years (1994–2008) at a large tertiary care cancer center to study all patients presenting with squamous cell carcinoma of the maxillary alveolus and hard palate treated surgically. Univariate and multivariate Cox regression analyses were used to identify predictors of DFS.ResultsNinety‐seven patients met the inclusion criteria (54 male, 56%). The majority of patients (54, 56%) presented with locally advanced disease (cT3, cT4). Occult nodal metastases were noted in 26% (17 of 65) of patients clinically staged as N0. The 3‐year DFS was 70% (95% confidence interval = 59%–78%) with a median time to failure of 1.1 years (range = 0.3–9.7 years). Cox regression multivariate model demonstrated that advanced pathologic T stage, hard palate tumor site, and poorly differentiated tumor grade were each independent predictors of DFS.ConclusionsA significant portion of the patients with hard palate and maxillary alveolus tumors harbor occult cervical metastases. Elective neck dissection in the high‐risk patients may potentially be beneficial in providing more accurate staging and improving DFS.Level of Evidence2b. Laryngoscope, 123:2453–2458, 2013
Transoral laser microsurgery for early glottic cancer as one‐stage single‐modality therapy
Authors: Lee Hyoung Shin , Chun Bong‐Gwon , Kim Sung Won , Kim Seung Tae , Oh Jung Ho , Hong Jong Chul , Lee Kang Dae 
Published: April 2013

Objectives/HypothesisA study was undertaken to determine the oncologic outcomes in a consecutive series of early glottic carcinomas treated with transoral CO2 laser microsurgery (TLM) as a one‐stage single‐modality therapy, without any postoperative radiation therapy or retreatment with laser. We further evaluated correlations between the oncologic outcomes and clinicopathologic factors including tumor location and surgical margin.Study DesignRetrospective analysis of medical records.MethodsThe medical records of 118 consecutive patients with early stage (T1, T2) glottic carcinoma who underwent TLM by a single surgeon as an initial treatment from 1997 to 2011 were retrospectively reviewed. The oncologic outcomes were evaluated, and correlations to clinicopathologic factors were analyzed.ResultsThe 5‐year disease‐free survival, ultimate local control with laser alone, disease‐specific survival, overall survival, and organ preservation rates were 87.9%, 94.2%, 99.0%, 92.2%, and 96.2%, respectively. Neither the reported surgical margin nor the extension of tumor to the anterior commissure, arytenoid, subglottis, and ventricle showed any significant impact on local control or survival.ConclusionsTransoral CO2 laser microsurgery as one‐stage single‐modality therapy resulted in a high rate of local control and a high survival rate in selected cases of early glottic carcinoma, regardless of the location of tumor and histopathology report on the surgical margin.Level of Evidence4 Laryngoscope, 123:2670–2674, 2013
Sinonasal adenoid cystic carcinoma
Authors: Sanghvi Saurin , Patel Neal R. , Patel Chirag R. , Kalyoussef Evelyne , Baredes Soly , Eloy Jean Anderson 
Published: April 2013

Objectives/HypothesisSinonasal adenoid cystic carcinoma (SNACC) is a rare malignancy that most commonly arises in the maxillary sinus. Characteristics of SNACC are slow growth, perineural invasion, and long clinical course. Because it is a rare tumor, population‐based studies are limited. We analyzed the incidence and survival for SNACC using a national population‐based database.Study DesignRetrospective cohort study using national cancer database.MethodsThe United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) registry was utilized to calculate incidence and survival trends for SNACC between 1973 and 2009. Patient data were then analyzed according to age, sex, and race. Incidence trends were studied for the last 30 years, and survival outcomes were compared across the different demographic parameters.ResultsA total of 412 cases of SNACC were identified (57.52% female). Incidence trend analysis revealed a significant decrease in yearly rates from 1973 to 2009 for the overall population, females, whites, blacks, and “others.” Overall 5‐year survival for SNACC was 68.80%, 10‐year survival was 48.03%, and 20‐year survival was 22.39%. Significant differences in survival outcomes were noted between whites, blacks, and “others.” “Others” had the best 20‐year survival outcomes.ConclusionsThe overall incidence of SNACC is declining. Sex and race seem to influence the overall survival for this rare tumor. Future studies need to be conducted to investigate these dynamic trends related to SNACC.Level of Evidence2b Laryngoscope, 2013
Head and neck trauma in Iraq and Afghanistan: Different war, different surgery, lessons learned
Authors: Brennan Joseph 
Published: April 2013

Objectives/HypothesisThe objectives are to compare and contrast the head and neck trauma experience in Iraq and Afghanistan and to identify trauma lessons learned that are applicable to civilian practice.Study DesignA retrospective review of one head and neck surgeon's operative experience in Iraq and Afghanistan was performed using operative logs and medical records.MethodsThe surgeon's daily operative log book with patient demographic data and operative reports was reviewed. Also, patient medical records were examined to identify the preoperative and postoperative course of care.ResultsThe head and neck trauma experiences in Iraq and Afghanistan were very different, with a higher percentage of emergent cases performed in Iraq. In Iraq, only 10% of patients were pretreated at a facility with surgical capabilities. In Afghanistan, 93% of patients were pretreated at such facilities. Emergent neck exploration for penetrating neck trauma and emergent airway surgery were more common in Iraq, which most likely accounted for the increased perioperative mortality also seen in Iraq (5.3% in Iraq vs. 1.3% in Afghanistan). Valuable lessons regarding soft tissue trauma repair, midface fracture repair, and mandible fracture repair were learned.ConclusionThe head and neck trauma experiences in Iraq and Afghanistan were very different, and the future training for mass casualty trauma events should reflect these differences. Furthermore, valuable head and neck trauma lessons learned in both war zones are applicable to the civilian practice of trauma.Level of EvidenceLevel 4. Laryngoscope, 123:2411–2417, 2013
NTHi induction of Cxcl2 and middle ear mucosal metaplasia in mice
Authors: Preciado Diego , Burgett Katelyn , Ghimbovschi Svetlana , Rose Mary 
Published: April 2013

Objectives/HypothesisChronic otitis media (COM) develops after sustained inflammation and is characterized by secretory middle ear epithelial metaplasia and effusion, most frequently mucoid. Nontypeable Haemophilus influenzae (NTHi), the most common acute otitis media (OM) pathogen, is known to activate inflammation and mucin expression in vitro and in animal models of OM. The goals of this study were to examine histopathological and expression profiling epithelial effects of NTHi challenge in murine middle ears.Study DesignIn vitro and in vivo murine model of OM.MethodsWeekly transtympanic inoculation of Balb/c mice with 300 μg/ml of NTHi lysates versus saline was performed. Histopathologic analysis was carried out at 4 weeks. Expression microarray analysis was performed at 1 and 7 days. Microarray findings were validated in independent animal samples and in a cultured murine middle ear epithelial cell (mMEEC) line.ResultsHistopathologic analyses revealed middle ear mucosal thickening after NTHi exposure. Microarray analyses of inflammatory response genes which changed significantly demonstrated that the chemokine Cxcl2 had the largest fold‐change, with significantly increased expression at 1 and 7 days after NTHi injection compared to either saline or no‐injection (P <0.01). Validation by real‐time qPCR revealed similar significantly increased relative mRNA levels for Cxcl2. NTHi lysates were also found to significantly upregulate the transcription of Cxcl2 in mMEEC in a time‐ and dose‐dependent manner (P <0.05).ConclusionsMiddle ear NTHi challenge in mice leads to chronic epithelial mucosal metaplasia and overexpression of inflammatory mediators, most notably Cxcl2. This finding is parallel to NTHi‐mediated pulmonary mucosal metaplasia where Cxcl2 has been identified as an important inflammatory mediator.Level of EvidenceN/A. Laryngoscope, 123:E66–E71, 2013
Pre‐operative urodynamics in women with stress urinary incontinence increases physician confidence, but does not improve outcomes
Authors: Zimmern Philippe , Litman Heather , Nager Charles , Sirls Larry , Kraus Stephen R. , Kenton Kimberly , Wilson Tracey , Sutkin Gary , Siddiqui Nazema , Vasavada Sandip , Norton Peggy ,   For the Urinary Incontinence Treatment Network
Published: April 2013

AbstractAimsTo determine if pre‐operative urodynamic testing (UDS) affects physicians' diagnostic confidence and if physician confidence affects treatment outcomes at 1 year.MethodsThe Value of Urodynamic Evaluation (ValUE) trial randomized 630 women with predominant stress urinary incontinence (SUI) to office evaluation (OE) or OE plus UDS prior to surgery. After OE, physicians completed a checklist of five clinical diagnoses: SUI, overactive bladder (OAB) wet and dry, voiding dysfunction (VD), and intrinsic sphincter deficiency (ISD), and reported their confidence in each. Responses ranged from 1 to 5 with; 1 = “not very confident (<50%)” to 5 = “extremely confident (95 + %).” After UDS, investigators again rated their confidence in these five clinical diagnoses. Logistic regression analysis correlated physician confidence in diagnosis with treatment success.ResultsOf 315 women who received OE plus UDS, 294 had complete data. Confidence improved after UDS in patients with baseline SUI (4.52–4.63, P < 0.005), OAB‐wet (3.55–3.75, P < 0.001), OAB‐dry (3.55–3.68 P < 0.005), VD (3.81–3.95, P < 0.005), and suspected ISD (3.63–3.92, P < 0.001). Increased confidence after UDS was not associated with higher odds of treatment success although mean changes in confidence were slightly higher for those who achieved treatment success. Physician diagnoses shifted more from not confident to confident for ISD and OAB‐wet after UDS (McNemar's P‐value <0.001 for both).ConclusionsIn women undergoing UDS for predominant SUI, UDS increased physicians' confidence in their clinical diagnoses; however, this did not correlate with treatment success. Neurourol. Urodynam. 33:302–306, 2014. © 2013 Wiley Periodicals, Inc.
Impact of transfer pricing methods for tax purposes on supply chain performance under demand uncertainty
Authors: Huh Woonghee Tim , Park Kun Soo 
Published: April 2013

AbstractTransfer pricing refers to the pricing of an intermediate product or service within a firm. This product or service is transferred between two divisions of the firm. Thus, transfer pricing is closely related to the allocation of profits in a supply chain. Motivated by the significant impact of transfer pricing methods for tax purposes on operational decisions and the corresponding profits of a supply chain, in this article, we study a decentralized supply chain of a multinational firm consisting of two divisions: a manufacturing division and a retail division. These two divisions are located in different countries under demand uncertainty. The retail division orders an intermediate product from the upstream manufacturing division and sets the retail price under random customer demand. The manufacturing division accepts or rejects the retail division's order. We specifically consider two commonly used transfer pricing methods for tax purposes: the cost‐plus method and the resale‐price method. We compare the supply chain profits under these two methods. Based on the newsvendor framework, our analysis shows that the cost‐plus method tends to allocate a higher percentage of profit to the retail division, whereas the resale‐price method tends to achieve a higher firm‐wide profit. However, as the variability of demand increases, our numerical study suggests that the firm‐wide and divisional profits tend to be higher under the cost‐plus method than they are under the resale‐price method. © 2013 Wiley Periodicals, Inc. Naval Research Logistics, 2013
Ellagic Acid and Derivatives from Cochlospermum angolensis Welw. Extracts: HPLC–DAD–ESI/MSn Profiling, Quantification and In Vitro Anti‐depressant, Anti‐cholinesterase and Anti‐oxidant Activities
Authors: Ferreres Federico , Grosso Clara , Gil‐Izquierdo Angel , Valentão Patrícia , Andrade Paula B. 
Published: April 2013

ABSTRACTIntroductionCochlospermum angolensis Welw. bark is a medicinal plant consumed for the treatment of hepatic diseases and for the prophylaxis of malaria. Nevertheless, there are few studies concerning its chemical composition and biological potential.ObjectiveSince phenolic compounds are described as powerful anti‐oxidants and neuroprotective agents, the purpose of this study was to characterise the phenolic profile of this species and to extend the knowledge on its medicinal properties, namely its potential against oxidative stress, Alzheimer's disease and depression.MethodsThe phenolic composition of aqueous and hydromethanolic extracts was characterised by HPLC–DAD–ESI/MSn. Anti‐radical potential was tested against 2,2‐diphenyl‐1‐picrylhdrazyl, superoxide anion and nitric oxide radicals, and neuroprotective effect was assessed against acetylcholinesterase, butyrylcholinesterase and monoamine oxidase A.ResultsEight compounds were characterised for the first time. Hydromethanolic extract was richer in methyl ellagic acid and its derivatives, while aqueous extract had higher amounts of ellagic acid and its derivatives. Methyl ellagic acid pentoside isomer and ellagic acid were the major compounds in the two extracts, respectively. Both extracts and ellagic acid revealed radical scavenging capacity stronger than that of ascorbic acid, but a weak effect on cholinesterases was observed. Their anti‐depressant activity was also very strong.ConclusionThe results provided evidence of the value of C. angolensis as a source of health‐promoting anti‐oxidants and anti‐depressant compounds, with potential to be used as a raw product for food and pharmaceutical industries. Copyright © 2013 John Wiley & Sons, Ltd.
A Simple and Rapid Single Kernel Screening Method to Estimate Amylose Content in Rice Grains
Authors: Agasimani Somanath , Selvakumar G. , Joel A. John , Ganesh Ram Sundaram 
Published: April 2013

ABSTRACTIntroductionIn rice breeding programmes large number of grain samples are routinely analysed for amylose content (AC) through a tedious spectrophotometric method that also involves high reagent costs.ObjectiveHere, we propose a rapid and economic screening technique for assessment of AC based on the amylose–iodine complex formation in the cut grains of rice, which we refer to as the cut grain dip (CGD) method.MethodsThe CGD method involves cutting the rice kernels in the middle with a pair of scissors and dipping the cut end in an optimised iodide:iodine (KI‐I) solution termed the rapid amylose detection solution (RADS).ResultsIt was found that the time taken for deep blue colouration by the cut end of the grains after dipping in RADS was proportional to the AC. The CGD method was further validated in a large set of rice mutants with varied AC.ConclusionThe proposed method can be used to screen samples for AC rapidly, with a single rice caryopsis, without any costly equipment and can be especially suitable for screening of mutants and segregants with altered AC in large breeding populations. Copyright © 2013 John Wiley & Sons, Ltd.
Cell‐free fetal DNA sex determination identified a maternal SRY gene with a known X chromosome deletion
Authors: Searle C. J. , Smith K. , Daniels G. , Maher E. J. , Quarrell O. 
Published: April 2013

What's already known about this topic?

Cell‐free fetal DNA testing is commonly used as a noninvasive method of determing fetal sex.
Presence of sex‐determining region Y (SRY) on the X chromosome is associated with a variable sexual phenotype.What does this study add?

Details an unexpected cell‐free fetal DNA sexing result.
Highlights the importance of using the technique of quantitative polymerase chain reaction in free fetal DNA testing.
If a similar result is found again, we would recommend further testing of the maternal chromosomes to look for a translocation encompassing the sex‐determining region Y (SYR) gene.
Effectiveness of the model for prenatal control of severe thalassemia
Authors: Tongsong Theera , Charoenkwan Pimlak , Sirivatanapa Pannee , Wanapirak Chanane , Piyamongkol Wirawit , Sirichotiyakul Supatra , Srisupundit Kasemsri , Tongprasert Fuanglada , Luewan Suchaya , Ratanasiri Thawalwong , Komwilaisak Ratana , Saksiriwuttho Piyamas , Vuthiwong Chutawadi , Punpuckdeekoon Peerapun , Panichkul Prisana , Rueangchainikhom Wibool , Choowong Jirawat , Orungrote Nawaporn , Sarapak Sravuth , Kovavisarach Ekachai , Jaruyawongs Prapon , Tansathit Thitinan , Phadungkiatwattana Podjanee , Rujiwetpongstorn Jittima , Kor‐anantakul Ounjai , Suwanrath Chitkasaem , Hanprasertpong Tharangrut , Pranpanus Savitree 
Published: April 2013

ABSTRACTObjectiveThe aim of the research was to determine effectiveness of the model for prenatal control in reducing new cases of severe thalassemia.MethodsPregnant women at six tertiary centers were recruited to follow the model, consisting of (1) carrier screening using mean corpuscular volume (for alpha‐thal‐1 and beta‐thal) and CMU‐E screen (for HbE trait), (2) carrier diagnosis, (3) the couples at risk were counseled and offered prenatal diagnosis, and (4) termination of affected pregnancy. All neonates were evaluated for thalassemia.ResultsOf the 12 874 recruited pregnancies, 7008 were valid for analysis. Of them, 281 couples were identified to be at risk, Of the 281, 58 affected fetuses were identified and 55 pregnancies were terminated, whereas three did not accept pregnancy termination. All 6727 neonates at no risk were proven to be unaffected. The model had sensitivity and positive predictive value of 100% and 20%, respectively. The model could detect all of affected fetuses.ConclusionThe model could prenatally identify affected fetuses with a detection rate and negative predictive value of 100%. The model was highly effective to prenatally detect affected fetuses with an acceptable false positive rate. © 2013 John Wiley &amp; Sons, Ltd.
Antihypertensive Drugs and the Risk of Congenital Anomalies
Authors: Vasilakis‐Scaramozza Catherine , Aschengrau Ann , Cabral Howard J. , Jick Susan S. 
Published: April 2013

Study ObjectiveTo estimate the prevalence of congenital anomalies among the offspring of women exposed and unexposed to antihypertensive drugs during early pregnancy.DesignMatched cohort study.DatabaseThe United Kingdom's General Practice Research Database.SubjectsWomen exposed to antihypertensive drugs during early pregnancy and a sample of matched unexposed pregnant women.Measurements and Main ResultsThe prevalence of any anomaly among unexposed and exposed women was 23.5 (95% confidence interval [CI] 14.4–38.3) and 20.9 (95% CI 10.0–43.8) per 1000 pregnancies, respectively (relative risk [RR] 0.9, 95% CI 0.4–2.2). The relative risk of limb anomalies among women exposed to β‐blockers was 6.4 (95% CI 0.6–70.1). Exposure to angiotensin‐converting enzyme (ACE) inhibitors, β‐blockers, and calcium channel blockers increased the risk of genital anomalies (RR 3.8, 95% CI 0.9–16.0; RR 2.8, 95% CI 0.7–11.9; RR 1.3, 95% CI 0.1–12.4, respectively).ConclusionACE inhibitors prescribed in the first trimester of pregnancy appeared to increase the risk of congenital anomalies among the offspring of exposed women (RR 2.5, 95% CI 0.5–13.5). These drugs should be avoided in women planning to become pregnant. A marginally increased risk was also found with exposure to β‐blockers (RR 1.4, 95% CI 0.6–3.3). These findings are based on small numbers and are not statistically significant.