bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complication analysis in nitinol stent-assisted embolization of 486 intracranial aneurysms
Authors: Johnson Andrew Kelly , Munich Stephan A. , Tan Lee A. , Heiferman Daniel Mark , Keigher Kiffon Marie , Lopes Demetrius Klee 
Published: May 2015

OBJECT
Stent-assisted embolization (SAE) has broadened the scope of endovascular cerebral aneurysm treatment. The risks associated with stent selection and configuration are poorly defined. In this study, the authors aimed to characterize the risk factors that contribute to complications in SAE of intracranial aneurysms.

METHODS
Over a 10-year period, a single surgeon treated 486 aneurysms with SAE in which open-cell Neuroform or closed-cell Enterprise stents were used. Single stents were used in 386 cases, overlapping stents were deployed in 80 cases, and Y-configuration stents were used in the remaining 20 cases. All neurological complications, which included transient deficits, were analyzed; disabling strokes and death were considered major complications. The chi-square test and multivariate logistic regression were used to evaluate the influence of aneurysm size and morphology, aneurysm location, stent selection, and stent configuration on complication rates.

RESULTS
There were 7 deaths (1.4%), 9 major strokes (1.9%), and 18 minor neurological complications (3.7%). For all complications, multivariate analysis revealed that large aneurysm size (10–25 mm; p = 0.01), giant aneurysm size (> 25 mm; p = 0.04), fusiform aneurysm morphology (p = 0.03), and using a Y-configuration stent (p = 0.048) were independent risk factors. For the major complications, independent risk factors included an aneurysm in the posterior circulation (p = 0.02), using an overlapping stent configuration (p = 0.03), and using a Y-configuration stent (p < 0.01).

CONCLUSIONS
In this series, SAE for cerebral aneurysm treatment carried an acceptable complication rate. With continued innovations in techniques and devices and with increased experience, the complication rates associated with SAE may be even lower in the future.
Continuous subcortical motor evoked potential stimulation using the tip of an ultrasonic aspirator for the resection of motor eloquent lesions
Authors: Shiban Ehab , Krieg Sandro M. , Obermueller Thomas , Wostrack Maria , Meyer Bernhard , Ringel Florian 
Published: May 2015

OBJECT
Resection of a motor eloquent lesion has become safer because of intraoperative neurophysiological monitoring (IOM). Stimulation of subcortical motor evoked potentials (scMEPs) is increasingly used to optimize patient safety. So far, scMEP stimulation has been performed intermittently during resection of eloquently located lesions. Authors of the present study assessed the possibility of using a resection instrument for continuous stimulation of scMEPs.

METHODS
An ultrasonic surgical aspirator was attached to an IOM stimulator and was used as a monopolar subcortical stimulation probe. The effect of the aspirator’s use at different ultrasound power levels (0%, 25%, 50%, 75%, and 100%) on stimulation intensity was examined in a saline bath. Afterward monopolar stimulation with the surgical aspirator was used during the resection of subcortical lesions in the vicinity of the corticospinal tract in 14 patients in comparison with scMEP stimulation via a standard stimulation electrode. During resection, the stimulation current at which an MEP response was still measurable with subcortical stimulation using the surgical aspirator was compared with the corresponding stimulation current needed using a standard monopolar subcortical stimulation probe at the same location.

RESULTS
The use of ultrasound at different energy levels did result in a slight but irrelevant increase in stimulation energy via the tip of the surgical aspirator in the saline bath. Stimulation of scMEPs using the surgical aspirator or monopolar probe was successful and almost identical in all patients. One patient developed a new permanent neurological deficit. Transient new postoperative paresis was observed in 28% (4 of 14) of cases. Gross-total resection was achieved in 64% (9 of 14) cases and subtotal resection (> 80% of tumor mass) in 35% (5 of 14).

CONCLUSIONS
Continuous motor mapping using subcortical stimulation via a surgical aspirator, in comparison with the sequential use of a standard monopolar stimulation probe, is a feasible and safe method without any disadvantages. Compared with the standard probe, the aspirator offers continuous information on the distance to the corticospinal tract.
Intraspinal psammomatous melanotic schwannoma not associated with Carney complex: case report
Authors: Shabani Saman , Fiore Susan M. , Seidman Roberta , Davis Raphael P. 
Published: May 2015

The authors present a case of intraspinal malignant psammomatous melanotic schwannoma (PMS) not associated with Carney complex and review all reported cases not associated with this syndrome. The focus of this review paper is on the characteristics of the malignant progression of PMS.
A 54-year-old man had a history of squamous cell carcinoma of the neck and tonsillar carcinoma. The patient’s serial CT scanning study showed a mass in the left C-5 foramen. On presentation he was neurologically intact. After 18 months, the patient developed radiating pain down the left arm with decreased sensation. MRI of the cervical spine showed an enhancing 2.1 × 1.5 × 1.9-cm mass in the left C5–6 foramen. A C5–6 hemilaminectomy was performed with gross-total removal of the tumor. At 3 months postoperatively, the patient developed new-onset pain and weakness. MRI showed a dumbbell-shaped mass in the left C-7 foramen. MRI of the pelvis showed a 1.4 × 1.0-cm lesion on the right ischium and a 1.1 × 2.8-cm lesion on the right inferior pubic ramus. Anterior cervical discectomy of C5–6 and C6–7 with corpectomy of C-6 with subtotal resection of the tumor was completed. PMS should not be considered a benign tumor because in 41.1% of patients, including the patient in this report, the tumor progresses to malignancy. Long-term follow-up is needed in these patients. New surgical treatment plans should be considered.
Drop-Landing Performance and Knee-Extension Strength After Anterior Cruciate Ligament Reconstruction
Authors: Kuenze Christopher M. , Foot Nathaniel , Saliba Susan A. , Hart Joseph M. 
Published: May 2015

Context
Individuals with a history of anterior cruciate ligament reconstruction (ACLR) are at greater risk of reinjury and developing early-onset osteoarthritis due to persistent abnormal joint loading. Real-time clinical assessment tools may help identify patients experiencing abnormal movement patterns after ACLR.

Objective
To compare performance on the Landing Error Scoring System (LESS) between participants with ACLR and uninjured control participants and to determine the relationship between LESS score and knee-extension strength in these participants.

Design
Controlled laboratory study.

Setting
Research laboratory.

Patients or Other Participants
Forty-six recreationally active participants, consisting of 22 with ACLR (12 men, 10 women; age = 22.5 ± 5.0 years, height = 172.8 ± 7.2 cm, mass = 74.2 ± 15.6 kg, body mass index = 24.6 ± 4.0) and 24 healthy control participants (12 men, 12 women; age = 21.7 ± 3.6 years, height = 168.0 ± 8.8 cm, mass = 69.2 ± 13.6 kg, body mass index = 24.3 ± 3.2) were enrolled.

Main Outcome Measure(s)
Bilateral normalized knee-extension maximal voluntary isometric contraction (MVIC) torque (Nm/kg) and LESS scores were measured during a single testing session. We compared LESS scores between groups using a Mann-Whitney U test and the relationships between LESS scores and normalized knee-extension MVIC torque using Spearman ρ bivariate correlations.

Results
The ACLR participants had a greater number of LESS errors (6.0 ± 3.6) than healthy control participants (2.8 ± 2.2; t44 = −3.73, P = .002). In ACLR participants, lower normalized knee-extension MVIC torque in the injured limb (ρ = −0.455, P = .03) was associated with a greater number of landing errors.

Conclusions
Participants with ACLR displayed more errors while landing. The occurrence of landing errors was negatively correlated with knee-extension strength, suggesting that weaker participants had more landing errors. Persistent quadriceps weakness commonly associated with ACLR may be related to a reduced quality of lower extremity movement during dynamic tasks.
A Comprehensive Profile of ChIP-Seq-Based Olig2 Target Genes in Motor Neuron Progenitor Cells Suggests the Possible Involvement of Olig2 in the Pathogenesis of Amyotrophic Lateral Sclerosis
Authors: Satoh Jun-Ichi , Asahina Naohiro , Kitano Shouta , Kino Yoshihiro 
Published: May 2015

Background Amyotrophic lateral sclerosis (ALS) is an intractable neurodegenerative disease that primarily affects motor neurons in the cerebral cortex and the spinal cord. Recent evidence indicates that dysfunction of oligodendrocytes is implicated in the pathogenesis of ALS. The basic helix–loop–helix (bHLH) transcription factor Olig2 plays a pivotal role in the development of both motor neurons and oligodendrocytes in the progenitor of motor neuron (pMN) domain of the spinal cord, supporting evidence for the shared motor neuron/oligodendrocyte lineage. However, a comprehensive profile of Olig2 target genes in pMNs and oligodendrocyte progenitor cells (OPCs) with relevance to the pathogenesis of ALS remains to be characterized. Methods By analyzing the ChIP-Seq datasets numbered SRP007566 and SRP015333 with the Strand NGS program, we identified genome-wide Olig2 target genes in pMNs and OPCs, followed by molecular network analysis using three distinct bioinformatics tools. Results We identified 5966 Olig2 target genes in pMNs, including Nkx2.2, Pax6, Irx3, Ngn2, Zep2 (Cip1), Trp3, Mnx1 (Hb9), and Cdkn1a, and 1553 genes in OPCs. The genes closely related to the keyword “alternative splicing” were enriched in the set of 740 targets overlapping between pMNs and OPCs. Furthermore, approximately one-third of downregulated genes in purified motor neurons of presymptomatic mutant SOD1 transgenic mice and in lumbar spinal cord tissues of ALS patients corresponded to Olig2 target genes in pMNs. Molecular networks of Olig2 target genes indicate that Olig2 regulates a wide range of genes essential for diverse neuronal and glial functions. Conclusions These observations lead to a hypothesis that aberrant regulation of Olig2 function, by affecting biology of both motor neurons and oligodendrocytes, might be involved in the pathogenesis of ALS.
Ninjas, princesas y robots gigantes: género, formato y contenido en el manganime
Authors: Torrents Alba G. 
Published: May 2015

<p>Este artículo se sirve de las nociones veronianas de género-L y género-P para intentar aportar un poco de luz a la problemática de la clasificación de géneros en el manga y el anime. Para ello, se adopta<br />estratégicamente la distinción entre género-L y género-P, aplicándola al manga y al anime, para mostrar a continuación que la aplicación de dichas categorías veronianas a este campo de producción cultural japonés es mucho más problemática de lo que puede parecer en un principio.</p>
Normative Data for Macular Volume with High-Definition Spectral-Domain Optical Coherence Tomography (Spectralis)
Authors: Murthy Ravi K. , Diaz Michelle , Chalam Kakarla V. , Grover Sandeep 
Published: May 2015

Purpose To establish normative data for macular volume by spectral-domain optical coherence tomography (SD-OCT) in subjects with no known retinal disease. Methods In an academic institutional setting, 50 subjects (age range 20–84 years) with no known retinal disease, best-corrected visual acuity 20/20, and normal intraocular pressure were enrolled. The subjects were divided into 3 age groups: group 1 included subjects 20–40 years of age, group 2 included subjects 41–60 years of age, and group 3 included subjects 61 years of age and older. All subjects underwent a complete ophthalmologic examination and testing, if needed, to rule out any retinal diseases or glaucoma. Retinal volume (RV) in 9 Early Treatment Diabetic Retinopathy Study (ETDRS) subfields and total macular volume (TMV) inclusive of all 9 subfields were analyzed. Statistical analyses were carried out using analysis of variance. Results Overall, the mean TMV ± SD for ETDRS circles with a diameter of 1, 2.22, and 3.45 mm was determined to be 3.04 ± 0.14 mm3. Among the ETDRS subfields, RV was highest in the nasal outer field, with a mean of 0.47 ± 0.02 mm3. The TMV did not show a significant difference with age (p = 0.17). However, TMV was significantly higher in males (p = 0.003) and in Caucasian and Asian subjects compared to African Americans (p = 0.017). Conclusions Normative values for total macular volume in ETDRS subfields in otherwise healthy eyes were measured to be 3.04 ± 0.14 mm3.
Low Wear, High Stability - Promises of Success in a Moderately Cross-Linked Cup?
Authors: Flatøy Bernhard , Rydinge Jonas , Dahl Jon , Röhrl Stephan M. , Nordsletten Lars 
Published: May 2015

Purpose Cross-linking has proven effective in reducing polyethylene wear in total hip replacements. However, increasing the amount of cross-links will impair other mechanical properties of the polyethylene. The optimal threshold of crosslinking has still not been established. This led to the development of a moderately cross-linked (5 Mrad) cemented cup in which wear and stability is yet to be determined. Methods A total of, 70 hips were included in this case series on the cemented Marathon® cup. Mean age of the patients was 78 years (SD 15). We measured wear and migration by radiostereometry at 3, 12 and 24 months. Results The proximal wear rate estimate between 3 to 24 months was 0.036 mm/year, and a total proximal wear estimate at 2 years of 0.11 mm (95% CI 0.09-0.14). Translations and rotations along the 3 cardinal axes were all at or below the precision limit, and less than what is believed to be predictive of later loosening, namely 0.2-1 mm for proximal migration. The cups remained stable after the initial “bedding in” that occurred during the first 3 months. Conclusions Our results indicate that moderate cross-linking (5Mrad) yields low wear and high stability in this specific acetabular cup, comparable to other cups with higher cross-linking.
Survival, Clinical and Radiological Outcome of the Zweymüller SL/Bicon-Plus Total Hip Arthroplasty: A 15-Year Follow-up Study
Authors: Ottink Karsten , Barnaart Lex , Westerbeek Robin , van Kampen Karin , Bulstra Sjoerd , van Jonbergen Hans-Peter 
Published: May 2015

Aim The primary aim of this study is to analyse the long-term results of the third generation of the “Zweymüller” total hip arthroplasty (THA) comprising the SL-Plus Stem and the Bicon-Plus cup. Methods We evaluated 208 patients with a SL/Bicon-Plus primary THA (218 hips). Survival analysis was performed with a follow-up of 13 to 15 years. Complementary clinical and radiological analysis was performed using the “Hip Injury and Osteoarthritis Outcome Score” (HOOS) and x-rays of the hips. Results The probability of survival of the stem and cup with revision for any reason was respectively 0.96/0.97 at 10 years and 0.92/0.94 at 15 years. The probability of survival of the stem and cup with revision for aseptic loosening was respectively 0.99/0.97 at 10 years and 0.95/0.94 at 15 years. Clinical assessment of the patients, reported by the HOOS, were scored with a median for the subdivisions: symptoms 90%, pain 93%, function in daily activity 87%, function in leisure or sport 75%, and quality of life with 75%. Periprosthetic radiolucent lines were observed in half of all hips in Gruen zones 1 and 7. Mean linear wear of the polyethylene was 1.8 mm which corresponds to 0.12 mm/year. 2/3 of the hips show heterotopic ossifications, mostly Brooker type 1 and 2. Conclusions The “third generation” Zweymüller total hip arthroplasty consisting of the SL stem and the Bicon cup has good long term results in terms of survival, clinical and radiological outcome.
Epidermolysis Bullosa Acquisita of MRSA Skin Carrier: A Case of Successful Total Hip Arthroplasty
Authors: Homma Yasuhiro , Baba Tomonori , Goto Kenji , Maruyama Yuichiro , Kaneko Kazuo 
Published: May 2015

Purpose Epidermolysis bullosa acquisita (EBA) is a very rare disease of a chronic autoimmune subepidermal blistering, usually manifesting as skin fragility, blisters and erosions. In this article, we report a successful THA in a patient with osteonecrosis of the femoral head with EBA and methicillin-resistant staphylococcus aureus (MRSA) skin carriage. Methods A 59-year-old woman had severe and debilitating left hip pain due to osteonecrosis of the femoral head. She had suffered from EBA for the past 7 years. She had received several courses of intravenous steroid pulse therapy in the past, and taking 6 mg of prednisone and 100 mg of minocycline per day for infected skin blisters. Severe blisters and scars covered her body, especially at the prone area. A bacteriological examination taken using a cotton-swab returned MRSA at the nasal cavity and anterolateral part of the proximal femur. Results We employed an antibiotic prophylactic protocol used for one-stage revision for infected hip prosthesis. Primary THA was performed using the anterior approach with antibiotic-loaded cement, and the skin was fully covered with a soft and conformable foam dressing.1-year post-op, there are no signs of infection. The Harris Hip Score improved from 37 pre-op to 93.4 at 1 year post-op. Conclusions Although care must be taken by medical professionals to avoid the prescription of unnecessary antibiotics, when used appropriately, there appears to be substantial benefits to be gained in the field of joint replacement for patients who are at high risk of infection.
Treatment of Massive Acetabular Bone Loss and Pelvic Discontinuity with a Custom Triflange Component and Ilio-Sacral Fixation Based on Preoperative CT Templating. A Report of 2 Cases
Authors: Hogan Craig , Ries Michael 
Published: May 2015

Revision rates for total hip arthroplasty are increasing and pelvic discontinuity is estimated to be present in 1% to 5% (Berry). Discontinuity is defined as a separation of the cephalad portion of the pelvis from the caudad portion (AAOS Type IV defects). This results from bone loss secondary to osteolysis, infection, fracture, or mechanical loosening. The goals of revision surgery in this setting are to obtain secure fixation of the acetabular component with or without union of the discontinuity. Many methods exist for treating this problem. Results with allograft and cage fixation have generally been poor (Berry, Hansen). More favourable outcomes have been reported using either a cup cage technique or custom triflange (Gross, Christie). The custom Triflange component is designed based on preoperative imaging with CT scan to manufacture a custom titanium implant to address the patient's specific bone loss pattern and obtain secure fixation in the ilium, pubis, and ischium. However, we have encountered cases of acetabular discontinuity with massive pelvic bone loss in which bone stock in the ilium was insufficient to provide support for proximal fixation of a conventional custom triflange component. Currently in the trauma patient population posterior pelvic ring disruptions are being treated with ilio-sacral screw fixation. The sacrum provides a source of secure bony fixation for these injuries. We report on 2 patients with pelvic discontinuity and massive bone loss using a technique to obtain proximal fixation of a custom triflange component into the sacrum.
Identifying novel biomarkers of gastric cancer through integration analysis of single nucleotide polymorphisms and gene expression profile
Authors: Wang Tao , Xu Yan , Hou Peng 
Published: May 2015

Purpose Single nucleotide polymorphisms (SNPs) are an important cause of functional variation in proteins leading to tumorigenesis. We aimed to identify candidate biomarkers with polymorphisms in gastric cancer (GC). Methods The SNP microarray profile GSE29996 including 50 GC samples and 50 normal controls, and gene expression data GSE56807 consisting of 5 GC samples and 5 controls were downloaded from the Gene Expression Omnibus database. After preprocessing of raw data, GC-associated SNPs were identified using the Cochran-Armitage trend test, and differentially expressed genes (DEGs) were screened out using the limma package in R. Significant DEGs with risk associated SNP loci were screened using the Fisher combination test. Gene ontology function and pathway enrichment analyses were performed for DEGs with risk associated SNP loci by GenCLip online tool. Transcriptional regulatory analysis was also conducted for transcription factor and target DEGs. Results A total of 79 DEGs with risk associated SNP loci were identified from GC samples compared with normal controls. These DEGs were mainly enriched in anatomical structure development, including embryo development. Additionally, DEGs were significantly involved in the NO1 pathway, including actin, alpha 1, skeletal muscle (ACTA1). In the regulatory network, transcription factor forkhead box L1 (FOXL1) regulated 26 DEGs with risk associated SNP loci, including Iroquois homeobox 1 (IRX1) rs11134044, sex determining region Y (SRY)-box1 (SOX1) rs9549447 and msh homeobox 1 (MSX1) rs41451149. Conclusions IRX1, SOX1 and MSX1 with risk associated SNP loci may serve as candidate biomarkers for diagnosis and prognosis of GC.
Early Access Ligation Resolves Presumed Ischaemic Monomelic Neuropathy in a Patient with Recurrence of Central Venous Occlusion
Authors: Coscione Alberto I.L. , Gale-Grant Oliver , Maytham Gary D. 
Published: May 2015

Purpose Ischaemic monomelic neuropathy (IMN) is a rare but serious complication of haemodialysis access procedures, with a highly variable clinical presentation. We present a case of presumed IMN managed with ligation of the prosthetic brachial-axillary access, leading to recovery of neurological function. Methods A 75-year-old male who underwent placement of a left prosthetic brachial-axillary access developed a swollen left upper limb following surgery and underwent interventional management for central venous occlusion. Results Eleven weeks following placement of the access, he presented with gross swelling and loss of function in the left arm. Ultrasonography excluded nerve compression. The brachial-axillary access was urgently ligated, leading to recovery of function in the arm. Electromyography (EMG) studies confirmed an ischaemic cause. Conclusions The pathophysiology of IMN is poorly understood. This case is atypical in that the patient suffered from central venous stenosis prior to the development of IMN. This raises the possibility that the gross swelling secondary to recurrent central venous occlusion may have led to an ischaemic neuropathy by altering nerve perfusion. Early management led to a functional recovery of the affected limb, suggesting that an urgent approach in patients with suspected IMN might be associated with the best outcomes.