bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interventions for fatigue in Parkinson's disease: A systematic review and meta‐analysis
Authors: Franssen Marloes , Winward Charlotte , Collett Johnny , Wade Derick , Dawes Helen 
Published: September 2014

AbstractThe authors sought to review the efficacy of interventions for fatigue in Parkinson's disease. A search was conducted of PubMed, Cinahl, Psychinfo, EMBASE, and Web of Knowledge up to November 2013. Methodological quality was assessed using the PEDro scale. For meta‐analyses, studies were weighted on variance. Effect sizes were calculated with 95% confidence interval (CI); overall effect was presented by means of a Z‐score; heterogeneity was investigated using the I2. Fourteen articles (n = 1,890) investigating drugs and behavioral therapy were eligible. Ten studies demonstrated excellent, three good, and one fair methodological quality. Three articles (investigating amphetamines) were appropriate for meta‐analysis, which was performed according to scales used: Multidimensional Fatigue Inventory: mean difference, –6.13 (95%CI: –14.63‐2.37, Z = 1.41, P = 0.16; I2 = 0); Fatigue Severity Scale: mean difference, –4.00 (95%CI: –8.72‐0.72, Z = 1.66, P = 0.10; I2 = 0). Currently insufficient evidence exists to support the treatment of fatigue in PD with any drug or nondrug treatment. Further study is required. © 2014 International Parkinson and Movement Disorder Society
Supplementation of bovine embryo culture medium with L‐arginine improves embryo quality via nitric oxide production
Authors: Santana Priscila Di Paula Bessa , Silva Thiago Velasco Guimarães , da Costa Nathália Nogueira , da Silva Bruno Barauna , Carter Timothy Frederick , Cordeiro Marcela da Silva , da Silva Bruno José Martins , Santos Simone do Socorro Damasceno , Herculano Anderson Manoel , Adona Paulo Roberto , Ohashi Otávio Mitio , Miranda Moysés dos Santos 
Published: September 2014

SUMMARYNitric oxide (NO) is a cell‐signaling molecule that regulates a variety of molecular pathways. We investigated the role of NO during preimplantation embryonic development by blocking its production with an inhibitor or supplementing in vitro bovine embryo cultures with its natural precursor, L‐arginine, over different periods. Endpoints evaluated included blastocyst rates, development kinetics, and embryo quality. Supplementation with the NO synthase inhibitor N‐Nitro‐L‐arginine‐methyl ester (L‐NAME) from Days 1 to 8 of culture decreased blastocyst (P < 0.05) and hatching (P < 0.05) rates. When added from Days 1 to 8, 50 mM L‐arginine decreased blastocyst rates (P < 0.001); in contrast, when added from Days 5 to 8, 1 mM L‐arginine improved embryo hatching rates (P < 0.05) and quality (P < 0.05) as well as increased POU5F1 gene expression (P < 0.05) as compared to the untreated control. Moreover, NO levels in the medium during this culture period positively correlated with the increased embryo hatching rates and quality (P < 0.05). These data suggest exerts its positive effects during the transition from morula to blastocyst stage, and that supplementing the embryo culture medium with L‐arginine favors preimplantation development of bovine embryos. Mol. Reprod. Dev. 81: 918–927, 2014. © 2014 Wiley Periodicals, Inc.
100% Efficient three‐dimensional coronary MR angiography with two‐dimensional beat‐to‐beat translational and bin‐to‐bin affine motion correction
Authors: Aitken Andrew P. , Henningsson Markus , Botnar Rene M. , Schaeffter Tobias , Prieto Claudia 
Published: September 2014

PurposeTo develop a flexible image navigator for 3D coronary MR angiography that allows respiratory motion of variable complexity to be compensated for on different temporal scales.MethodsA two‐dimensional (2D) golden radial image navigator is proposed; translational motion is compensated for on a beat‐to‐beat basis, and residual affine motion is compensated for on a bin‐to‐bin basis in a two‐step procedure. The method does not use a respiratory gating window and therefore achieves 100% scan efficiency and a predictable scan time. The proposed method was tested in 11 healthy volunteers and compared against a navigator‐gated and tracked acquisition.ResultsThe proposed method achieved comparable quantitative and qualitative image quality to a 6‐mm navigator‐gated and tracked scan while reducing the scan time by a factor of approximately 2. Combined motion correction using image navigators improved visualization of the coronary arteries in four of 11 subjects in comparison with translational correction only, and image quality was maintained in the remaining cases. In one case, visualization of the left anterior descending coronary artery was degraded using combined correction compared with translation correction only.ConclusionsThe feasibility of correcting for 2D translational motion on a beat‐to‐beat basis as well as affine motion on a bin‐to‐bin basis has been demonstrated. Magn Reson Med 74:756–764, 2015. © 2014 The Authors. Magnetic Resonance in Medicine Published by Wiley Periodicals, Inc. on behalf of International Society of Medicine in Resonance.
Single nucleotide variations: Biological impact and theoretical interpretation
Authors: Katsonis Panagiotis , Koire Amanda , Wilson Stephen Joseph , Hsu Teng‐Kuei , Lua Rhonald C. , Wilkins Angela Dawn , Lichtarge Olivier 
Published: September 2014

AbstractGenome‐wide association studies (GWAS) and whole‐exome sequencing (WES) generate massive amounts of genomic variant information, and a major challenge is to identify which variations drive disease or contribute to phenotypic traits. Because the majority of known disease‐causing mutations are exonic non‐synonymous single nucleotide variations (nsSNVs), most studies focus on whether these nsSNVs affect protein function. Computational studies show that the impact of nsSNVs on protein function reflects sequence homology and structural information and predict the impact through statistical methods, machine learning techniques, or models of protein evolution. Here, we review impact prediction methods and discuss their underlying principles, their advantages and limitations, and how they compare to and complement one another. Finally, we present current applications and future directions for these methods in biological research and medical genetics.
Copper(II) Coordination Polymers Generated from 1,3‐Bis(4‐pyridyl)propane: Synthesis, Structures, and Spectroscopic Studies
Authors: Farani Regis A. , Da Fonseca Daniella M. F. , De Paula Elgte Elmin B. , Bortoluzzi Adailton J. , Hörner Manfredo , Diniz Renata , Machado Flávia C. 
Published: September 2014

AbstractThis paper describes the synthesis and structural characterization of two new one‐dimensional coordination polymers involving 1,3‐bis(4‐pyridyl)propane ligand named {(μ‐NCS)2[Cu(bpp)]·dmf}n (1) and {[Cu(mebpy)(bpp)(dmso)](ClO4)2·dmso}n (2) (bpp = 1,3‐bis(4‐pyridyl)propane and mebpy = 4,4'‐dimethyl‐2,2'‐bipyridine). These compounds were characterized by means of elemental analysis, thermal analysis (TG/DTA), vibrational spectroscopy (IR and Raman) and had their structures determined by single‐crystal X‐ray diffraction analysis. Compound 1 consists of CuN4 coordination spheres with bpp ligands in the unusual GG conformation coordinated in bridges between CuII centers to form a wavelike 1‐D coordination polymer. On the other hand, in compound 2 the bpp ligand adopts the TT conformation in bridging mode extending the 1D cationic polymeric chain.
Two Non‐Isostructural Gadolinium Oxide Nitride Chalcogenides: Gd3ONSe2 and Gd3ONTe2
Authors: Foltin Markus L. , Talmon‐Gros Pia , Schleid Thomas 
Published: September 2014

AbstractTwo new non‐isostructural gadolinium(III) oxide nitride chalcogenides with the composition Gd3ONCh2 bearing selenide (Gd3ONSe2) and telluride (Gd3ONTe2) could be synthesized by the reaction of gadolinium metal (Gd) with gadolinium sesquioxide (Gd2O3), sodium azide (NaN3), selenium (Se) or tellurium (Te), iodine (I2) and sodium iodide (NaI) as flux in evacuated silica tubes for seven days at 850 to 950 °C. Yellow lath‐shaped single crystals of Gd3ONSe2 crystallize isotypically to Tb3ONSe2 in the monoclinic space group C2/m with the lattice parameters a = 1560.12(9), b = 395.24(2), c = 977.35(6) pm, β = 97.321(3)° (Z = 4). In contrast, orthorhombic Gd3ONTe2 forms black rods, appears in the space group Pnma with the lattice parameters a = 1337.87(8), b = 408.47(2), c = 1216.78(7) pm (Z = 4) and adopts the crystal structure of Nd3N2SeBr. Three crystallographically independent Gd3+ cations can be found in both oxide nitride chalcogenides, but their coordination spheres are different. The Gd3+ cations in Gd3ONSe2 occupy the centers of one capped trigonal prism and two distorted octahedra of anions. Two octahedra, one with a cap, and a square antiprism can be seen for the anionic polyhedra of coordination for the Gd3+ cations in Gd3ONTe2. As main structural features $\rm^{1}_{\infty}${[ONGd3]4+} double chains, containing edge‐connected [NGd4]9+ and [OGd4]10+ tetrahedra, run along [010] in both compounds, but show two diverse detailed morphologies. A porous arrangement, which is obtained by a different linkage pattern of the light‐anion centered (Gd3+)4 tetrahedra can be detected in Gd3ONSe2, whereas the denser form of connectivity is seen in Gd3ONTe2. In both cases [OGd4]10+ tetrahedra represent the central components of the double chains leading to an ordering of the light anions in both structures as it is already known for Tb3ONSe2.
A Meta‐analysis of the Predictive Accuracy of Postoperative Mortality Using the American Society of Anesthesiologists’ Physical Status Classification System
Authors: Koo Chieh Yang , Hyder Joseph A. , Wanderer Jonathan P. , Eikermann Matthias , Ramachandran Satya Krishna 
Published: September 2014

AbstractBackgroundThe American Society of Anesthesiologists’ physical status (ASA) tool has been applied to determine compensation, risk adjustment and risk prediction, but little is known about the accuracy and generalizability of this tool for prediction of postoperative mortality.MethodsWe systematically investigated prior published reports of associations between ASA physical status and mortality to test the hypothesis that ASA physical status will have varying accuracy in prediction of postoperative mortality across surgical populations with varying surgical risk of mortality. We used random effects models and metaregression to account for heterogeneity.ResultsCombining 77 studies with 165,705 patients, the ASA physical status tool demonstrated the following pooled performance (95 % confidence intervals)—sensitivity 0.74 (0.73, 0.74), specificity 0.67 (0.67, 0.67), and area under summary receiver operating curve 0.736 (0.725, 0.747). Metaregression revealed that study death rates and surgical specialty were significant factors.ConclusionASA physical status is a better predictor of postoperative mortality in settings with lower rather than higher death rates.
Assessment of Parental Understanding of Positive Newborn Screening Results and Carrier Status for Cystic Fibrosis with the use of a Short Educational Video
Authors: Temme R. , Gruber A. , Johnson M. , Read L. , Lu Y. , McNamara J. 
Published: September 2014

AbstractMany children are identified as unaffected carriers for cystic fibrosis (CF) through newborn screening (NBS) programs. The aim of this study was to improve parental understanding of positive NBS results using an educational video in addition to genetic counseling. One hundred parents of infants identified as CF carriers through NBS were randomly assigned by household to either a genetic counseling only group or a genetic counseling and video group. All participants completed a knowledge‐based questionnaire before, immediately after, and six weeks following genetic counseling. This included questions about resources accessed before and after the appointment. Seventy‐two percent of participants accessed resources on their own prior to genetic counseling; these participants scored significantly higher on the pre‐counseling questionnaire (p = 0.03). Post‐counseling knowledge scores for both groups significantly improved after genetic counseling (p < 0.001). Post‐counseling scores were significantly higher in the video group compared to the non‐video group (p = 0.02). Knowledge was retained six weeks following genetic counseling. This study demonstrates the effectiveness of an educational video and reinforces the importance of genetic counseling following positive NBS results for CF.
Reliability of Handgrip Strength Test in Elderly Subjects with Unilateral Thumb Carpometacarpal Osteoarthritis
Authors: Villafañe Jorge Hugo , Valdes Kristin , Vanti Carla , Pillastrini Paolo , Borboni Alberto 
Published: September 2014

Background The grip strength test is widely used; however, little has been investigated about its reliability when used in elderly with subjects thumb carpometacarpal (CMC) osteoarthritis (OA). The purpose of this study was to examine the test–retest reliability of the grip strength test in elderly subjects with thumb CMC OA. Methods A total of 78 patients with unilateral thumb CMC OA, 84.6 % female (mean±SD age 83±5 years), were recruited. Each patient performed three pain free maximal isometric contractions on each hand in two occasions, 1 week apart. Intraclass correlation coefficient (ICC), standard error of measurement (SEM), and 95 % limits of agreement (LOA) were calculated. Results Test–retest reliability was excellent for side affected (ICC=0.947; p=0.001) and contralateral (ICC=0.96; p=0.001) thumb CMC OA. Conclusions The present results indicate that maximum handgrip strength can be measured reliably, using the Jamar hand dynamometer, in patients with thumb CMC OA, which enables its use in research and in the clinic to determine the effect of interventions on improving grip.
On the sunk-cost effect in economic decision-making: a meta-analytic review
Authors: Roth Stefan , Robbert Thomas , Straus Lennart 
Published: September 2014

AbstractAlthough the effect of monetary sunk costs on decision-making is widely discussed, research is still fragmented, and results are sometimes controversial. One reason for this incomplete picture is the missing differentiation between the effect of sunk costs on utilization and progress decisions and its respective moderators. This article presents the results of a meta-analytic review of 98 effect sizes of the sunk-cost effect, with special emphasis on the decision-specific influence of moderators. The results show clear evidence that the sunk-cost effect emerges, though its effect size and the influence of the moderators are contingent on the respective decision type. In particular, we find support for the idea that the sunk-cost effect is attenuated by time in utilization decisions. The results also reveal that older adults are less likely to fall prey to the sunk-cost effect than younger adults.
Paths to Work after Stroke in Australia
Authors: Killey J. , Gustafsson L. , Hoyle M. 
Published: September 2014

Background and aims: Previous research has focused primarily on incidence rates and barriers/facilitators influencing return to work, without considering the formal paths accessed by people with stroke. The aim of this study was to identify the paths used by Australian people to return to work following stroke, including changes to work-related habits and routines, and job satisfaction.Methods: This descriptive, retrospective study recruited people through newsletters and online forums for people with stroke. The quantitative data were summarised descriptively and the Wilcoxon signed-rank test was used to compare pre- and post-stroke job satisfaction rates.Results: Participants (n= 21) were aged 48 years on average, female (67%) and university trained (71%). Ten (48%) participants did not access formal return-to-work services, yet participants commonly reported changes to work-related habits and routines. Participants were significantly less satisfied with their post-stroke job suitability (physically, cognitively and financially), stability and importance (p< .05).Conclusion: Participants in this small-scale study did not routinely access formal support services to return to work, while experiencing changes to work-related habits and satisfaction. Further research is required to document the return-to-work paths, including the experience from the perspective of the person with stroke.
Pump phase transfer and its control in hybrid seeded optical parametric amplifiers
Authors: Yuan Peng , Ma Jingui , Wang Yongzhi , Wang Jing , Tang Daolong , Qian Liejia 
Published: September 2014

Abstract
Due to the existence of spatial walk-off and/or group-velocity mismatch effects, pump-to-signal phase transfer becomes inevitable during parametric amplification. We experimentally demonstrate that in hybrid seeded optical parametric amplifiers (OPAs) that include two OPA stages seeded by the signal and idler waves, respectively, the phase of the output signal can be restored to its initial value, although there are spatial and temporal phase fluctuations on the pump source. This method significantly relaxes the requirement for high pump beam quality, which is always very stringent in parametric amplification systems. With the introduction of this scheme into birefringent phase-matching OPAs or chirped-pulse OPAs, it should be promising to achieve intense femtosecond laser pulses that are close to the diffraction limit in space and ultra-high contrast in time, simultaneously.
Exploratory meta-analysis on deep brain stimulation in treatment-resistant depression
Authors: Smith Donald F. 
Published: September 2014

ObjectiveDeep brain stimulation is currently an experimental treatment for major depressive disorder. Information is lacking, however, on how sham responding may affect efficacy. This article applies exploratory meta-analysis to address that topic.MethodsData on benefits of deep brain electrical stimulation come from a recent review. Stimulated brain regions included subgenual cingulate, capsular interna, nucleus accumbens, and medial forebrain bundle. Expert opinion plus random number software was used to generate hypothetical values for sham responding.ResultsAn effect size of 1.71 (95% CI: 1.47–1.96) was obtained for deep brain stimulation versus sham treatment in patients suffering from long-term treatment-resistant depression.ConclusionPreliminary findings on deep brain electrical stimulation suggest that the procedure may be 71% more effective than sham treatment. Expressing these findings as patients-needed-to-treat, deep brain electrical stimulation is required by 2.9 patients with long-term treatment-resistant depression in order for one of them to benefit.
Ramadan fasting and newborn's birth weight in pregnant Muslim women in The Netherlands
Authors: Savitri Ary I. , Yadegari Nasim , Bakker Julia , van Ewijk Reyn J. G. , Grobbee Diederick E. , Painter Rebecca C. , Uiterwaal Cuno S. P. M. , Roseboom Tessa J. 
Published: September 2014

Many Muslim women worldwide are pregnant during Ramadan and adhere to Ramadan fasting during pregnancy. In the present study, we determined whether maternal adherence to Ramadan fasting during pregnancy has an impact on the birth weight of the newborn, and whether the effects differed according to trimester in which Ramadan fasting took place. A prospective cohort study was conducted in 130 pregnant Muslim women who attended antenatal care in Amsterdam and Zaanstad, The Netherlands. Data on adherence to Ramadan fasting during pregnancy and demographics were self-reported by pregnant women, and the outcome of the newborn was retrieved from medical records after delivery. The results showed that half of all the women adhered to Ramadan fasting. With strict adherence to Ramadan fasting in pregnancy, the birth weight of newborns tended to be lower than that of newborns of non-fasting mothers, although this was not statistically significant ( − 198 g, 95 % CI − 447, 51, P= 0·12). Children of mothers who fasted in the first trimester of pregnancy were lighter at birth than those whose mothers had not fasted ( − 272 g, 95 % CI − 547, 3, P= 0·05). There were no differences in birth weight between children whose mothers had or had not fasted if Ramadan fasting had taken place later in pregnancy. Ramadan fasting during early pregnancy may lead to lower birth weight of newborns. These findings call for further confirmation in larger studies that should also investigate potential implications for perinatal and long-term morbidity and mortality.
Quand les mouvements sociaux changent le politique. Le cas du mouvement étudiant de 2012 au Québec
Authors: Dufour Pascale , Savoie Louis-Philippe 
Published: September 2014

RésuméÀ travers l'analyse du conflit étudiant du printemps 2012 au Québec, nous montrons comment les mouvements sociaux peuvent changer, temporairement, le politique. Le politique est entendu ici comme l'ensemble des règles et pratiques individuelles et collectives qui régissent les relations entre les acteurs à propos du gouvernement de la communauté. Plus précisément, nous montrons que le mouvement de contestation a transformé le politique de trois manières. Premièrement, les six mois du conflit étudiant ont créé un nouveau clivage autour duquel la vie politique s'est réorganisée. Deuxièmement, les acteurs partisans et les associations étudiantes ont modifié leurs pratiques et actions quotidiennes, redéfinissant leur mode de relations et leur politique d'alliance. Troisièmement, l'expérience prolongée de la mobilisation a changé le rapport au politique pour les individus mobilisés en bousculant les articulations usuelles entre l'usage de la politique institutionnelle et celui de la politique protestataire.