bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of clinically relevant health conditions on psychosocial outcomes in survivors of childhood cancer: results of the DCCSS-LATER study
Authors: Maas Anne , Maurice-Stam Heleen , Feijen Lieke E.A.M. , Teepen Jop C. , van der Aa-van Delden Alied M. , Streefkerk Nina , van Dulmen-den Broeder Eline , Tissing Wim J. E. , Loonen Jacqueline J. , van der Pal Helena J. H. , de Vries Andrica C. H. , van den Heuvel-Eibrink Marry M. , Ronckers Cécile , Neggers Sebastian , Bresters Dorine , Louwerens Marloes , Versluys Birgitta A. B. , van der Heiden-van der Loo Margriet , Kremer Leontien C. M. , Grootenhuis Martha ,   the Dutch LATER study group
Published: June 2024

Abstract
Purpose
Investigate the association between presence, number and type of clinically relevant health conditions and a range of psychosocial outcomes (emotional, social, cognitive, physical) in survivors of childhood cancer (CCS).

Methods
CCS from the Dutch Childhood Cancer Survivor Study (DCCSS)-LATER cohort (diagnosed between 1963–2001, attained age ≥ 18, diagnosed < 18, ≥ 5 years since diagnosis) completed a questionnaire on health conditions (2013–2014), and questionnaires on psychosocial outcomes (2017–2020): Hospital Anxiety and Depression Scale, Short form 36, TNO-AZL Questionnaire for Adult Health-Related Quality of Life, and the Self-Rating Scale for Post-Traumatic Stress Disorder. Associations among health conditions and psychosocial outcomes were assessed with regression analysis, adjusting for attained age, sex, and time since diagnosis, and adjusting for multiple testing (p < 0.004).

Results
A total of 1437 CCS, mean age 36.3 years, 51.1% female, ≥ 15 years since diagnosis, completed questionnaires on health and psychosocial outcomes. CCS with a clinically relevant health condition, and those with more conditions had worse emotional, social, and physical outcomes; regression coefficients were small to moderate. CCS with gastro-intestinal conditions, endocrine, nervous systems, eye, or ear conditions, and especially those with secondary malignant neoplasms, reported worse psychosocial functioning; regression coefficients were small/moderate to large.

Conclusion and implications
Health care professionals should be aware of the increased risk for psychosocial problems among CCS with health conditions, especially for survivors with secondary malignant neoplasms, gastro-intestinal, endocrine, nervous system, eye, and ear conditions. CCS may benefit from psychological interventions to develop coping strategies to manage health conditions and psychosocial consequences of the cancer trajectory.
A Review of Probabilistic Approaches for Assessing the Liquefaction Hazard in Urban Areas
Authors: Cruz Alejandro , Karimzadeh Shaghayegh , Chieffo Nicola , Sandoval Eimar , Lourenço Paulo B. 
Published: June 2024

AbstractSeveral probabilistic liquefaction triggering approaches, or liquefaction manifestation severity approaches, have been developed to consider the uncertainties related to liquefaction and its manifestations. Probabilistic approaches are essential for vulnerability and risk models that considers the consequences of liquefaction on building performance. They may be incorporated into a performance-based earthquake engineering framework through a fully probabilistic liquefaction hazard assessment. The objective is to effectively incorporate spatial interaction of two concurrent hazards, specifically earthquake-induced shaking, and liquefaction, and to develop a robust multi-hazard framework applicable to regions with limited input data. For this purpose, it is necessary to establish, according to the available probabilistic liquefaction triggering or manifestation severity assessment approaches, which set of approaches aligns optimally with vulnerability and risk models. Thus, this paper discusses the current methodologies on the ongoing probabilistic liquefaction hazard assessment approaches with the aim of defining a reliable model specific for areas with a non-liquefiable surface layer over a liquefiable layer.
Advances in the Treatment of Neuropathic Pain by Sympathetic Regulation
Authors: Xu Ping , Fan Han Rui , Zhang En Ming , Zhang Hao Nan , Fei Yong 
Published: June 2024

Abstract
Purpose of Review
To explore the mechanism and therapeutic effect of sympathetic nerve regulation on neuropathic pain.

Recent Findings
A comprehensive search was conducted in the PubMed and CNKI libraries, using the following keywords: stele ganglion block, neuropathic pain, sympathetic nerve block, sympathetic chemical destruction, and sympathetic radiofrequency thermocoagulation. We selected and critically reviewed research articles published in English that were related to sympathetic modulation in the treatment of neuropathic pain. The collected literature will be classified according to content and reviewed in combination with experimental results and clinical cases. Neuropathic pain was effectively treated with sympathetic regulation technology. Its mechanism includes the inhibition of sympathetic nerve activity, regulation of the inflammatory response, and inhibition of pain transmission, which greatly alleviates neuropathic pain in patients. Stellate ganglion blocks, thoracic and lumbar sympathectomies, chemical destruction, and radiofrequency thermocoagulation have been widely used to treat neuropathic pain.

Summary
Sympathetic regulation can effectively relieve pain symptoms and improve the patient's quality of life by inhibiting sympathetic nerve activity, reducing the production and release of pain-related mediators, and inhibiting pain transmission. CT-guided radiofrequency thermocoagulation of the thoracic and lumbar sympathetic nerves is effective and durable, with few complications, and is recommended as a treatment for intractable neuropathic pain.
Comprehensive machinability assessment of Ti6Al4V alloy during drilling and helical milling using sustainable dry condition
Authors: Hiremath Anupama , Malghan Rashmi L. , Bolar Gururaj , Polishetty Ashwin 
Published: June 2024

AbstractCutting fluids are an essential requirement while machining materials like Ti6Al4V alloy exhibiting low thermal conductivity and work hardening behavior. However, the non-biodegradable nature of the oil increases carbon emissions and causes serious health concerns, thus jeopardizing sustainability. In addition, complexity increases when drilling Ti6Al4V alloy due to the temperature build-up, leading to material adhesion and accelerated tool wear. The study, therefore, investigates the utility of helical milling for creating holes in Ti6Al4V alloy. The hole-making operations were appraised considering the chip morphology, microhardness, machining temperature, tool wear, and surface roughness. The findings show that hole-making using helical milling was beneficial since it produced lower thrust force. Measured temperatures during helical milling were significantly lower than in drilling. Helically milled holes displayed superior quality holes with lower surface roughness; however, at higher productivity conditions, chatter marks were noted. The microhardness was lower near the machined surface in the case of conventional drilling, indicating material softening. In comparison, helical milled holes displayed higher microhardness very close to the edge of the hole due to work hardening. The helical milling operation produced short discontinuous chips, which are desirable while machining Ti6Al4V alloy. Furthermore, the examination of the cutting tool showed material adhesion. The severity of tool damage was significantly lower during the helical milling operation. The initial assessment indicates that helical milling is an adept process for making holes in Ti6Al4V alloy.
Effect of Nb on Austenite Grain Growth in 10Cr-3Co-2W Martensitic Heat-Resistant Steel
Authors: Park Bong Cheon , Kim Sung-Dae , Park Ihho , Shin Jong-Ho , Jang Jae Hoon , Kang Namhyun 
Published: June 2024

Abstract
The effect of Nb on austenite grain growth kinetics was investigated in 10Cr-3Co-2W martensitic heat-resistant steel under various tempering conditions (temperature and time). The results demonstrate that Nb effectively refines the austenite grain size; this result is attributed to the combined effect of Nb atom solute drag effect and pinning effect of NbC precipitates. Based on the measured values, an empirical model was developed to predict the grain growth behavior of this alloy system. In addition, the key conditions and parameters for application to the microstructure evolution model of MatCalc software were derived. Results will enable the prediction of grain size at different Nb contents and temperature parameters, and provide useful information for designing heat treatment processes and alloys.

Graphic Abstract
You Can Lead an Adolescent to Mindfulness, but You Can’t Make Them Mindful
Authors: Johnson Catherine , Taylor Amanda , Dray Julia , Dunning Darren 
Published: June 2024

AbstractMeta-analyses of mindfulness-based interventions (MBIs) in schools consistently show small, positive effects, but the field remains dominated by studies with low methodological rigour. Recent large randomised controlled trials in adolescents demonstrate poor traction in this age group together with some adverse effects, creating a crossroads for their future. In their recent commentary on the null effects of the MYRIAD trial (Kuyken et al., 2022), Strohmaier and Bailey (2023) postulated that making mindfulness practice available within the school day may increase the dosage and benefits of MBIs for adolescents, and called for funders to direct efforts at developing and testing this approach. We agree that identifying ways to increase dose beyond weekly classroom lessons is important, but explore whether this suggestion is practical or developmentally appropriate for secondary school settings. Our commentary broadens to group together other large and moderately large RCTs that have also shown disappointing results in adolescents, and presents seven barriers that together may be compounding the lack of effect in this age group. We offer alternative suggestions for future school-based research and delivery of MBIs.
Breast cancer stage and molecular subtype distribution: real-world insights from a regional oncological center in Hungary
Authors: Tittmann Judit , Ágh Tamás , Erdősi Dalma , Csanády Bettina , Kövér Erika , Zemplényi Antal , Kovács Sándor , Vokó Zoltán 
Published: June 2024

Abstract
Objective
Examining the distribution of breast cancer (BC) stage and molecular subtype among women aged below (< 45 years), within (45–65 years), and above (> 65 years) the recommended screening age range helps to understand the screening program's characteristics and contributes to enhancing the effectiveness of BC screening programs.

Methods
In this retrospective study, female patients with newly diagnosed BC from 2010 to 2020 were identified. The distribution of cases in terms of TNM stages, severity classes, and subtypes was analysed according to age groups.

Results
A total of 3282 women diagnosed with BC were included in the analysis. Among these cases 51.4% were detected outside the screening age group, and these were characterized by a higher TNM stage compared to those diagnosed within the screening age band. We observed significantly higher relative frequency of advanced BC in the older age group compared to both the screening age population and women younger than 45 years (14.9% vs. 8.7% and 7.7%, P < 0.001). HR−/HER2− and HER+ tumours were relatively more frequent among women under age 45 years (HR−/HER2−: 23.6%, HER2+: 20.5%) compared to those within the screening age range (HR−/HER2−: 13.4%, HER2+: 13.9%) and the older age group (HR−/HER2−: 10.4%, HER2+: 11.5%).

Conclusions
The findings of our study shed light on potential areas for the improvement of BC screening programs (e.g., extending screening age group, adjusting screening frequency based on molecular subtype risk status) in Hungary and internationally, as well.
Childhood Cancer Awareness Program in Bungoma County, Kenya
Authors: Klootwijk Larissa , Osamong Lilian Apadet , Langat Sandra , Njuguna Festus , Kimaiyo Sally , Vik Terry A. , Kaspers Gertjan , Mostert Saskia 
Published: June 2024

Abstract

Background
Awareness could play a key role in reducing underdiagnosis and accelerating referral of childhood cancer in low- and middle-income countries and ultimately improve outcomes. This study describes the implementation of a childhood cancer awareness program in Bungoma County in Kenya, containing five components: (1) baseline data collection of primary healthcare facilities; (2) live training session for healthcare providers (HCP); (3) early warning signs posters; (4) online SMS course for HCP; and (5) radio campaign.

Methods
This study was conducted between January and June 2023. All 144 primary healthcare facilities (level 2 and 3 health facilities) within Bungoma County were visited by the field team.

Results
All 125 level 2 (87%) and 19 level 3 (13%) facilities participated in the study. National Health Insurance Fund (NHIF) failed to cover services in 37 (26%) facilities. HCP were more often reported absent at level 3 (89%) than level 2 (64%) facilities (P = 0.034). The 144 live training sessions were attended by over 2000 HCP. Distribution of 144 early warning signs posters resulted in 50 phone calls about suspected childhood cancer cases. Sixteen children were later confirmed with childhood cancer and treated. Online SMS learning was completed by 890 HCP. Knowledge mean scores improved between pre-test (7.1) and post-test (8.1; P < 0.001). Finally, 540 radio messages about childhood cancer and a live question-and-answer session were broadcasted.

Conclusion
This study described the implementation of a childhood cancer awareness program in Kenya involving both HCP and the general public. The program improved HCP’s knowledge and increased the number of referrals for children with cancer.
Fiber Optic Vacuum Ultraviolet Sensor Based on an AlN-Microwire Probe
Authors: Wang Ying , Ye Jiahui , Ma Dingbang , Wang Peiyao , Li Baikui , Sun Zhenhua , Wu Honglei , Liao Changrui , Wang Yiping 
Published: June 2024

AbstractVacuum ultraviolet (VUV) light sensing shows great potential applications in the space science, materials, biophysics, and plasma physics. In this work, an all-optical detection method is proposed for VUV sensing by constructing an optical fiber-end Fabry-Pérot interferometer based on a single aluminum nitride (AlN) microwire. Compared with the traditional electrical devices, this all-optical detection method overcomes the difficulties like the fast response and electromagnetic interference immunity in detecting VUV bands at the present stage, and improves the response speed. The proposed device shows the excellent performance of VUV detection, with the static sensitivity of 1.03 nm/(W·cm−2), response rise time of down to 10 µs, and decay time of 0.64 ms. Beneficial from the excellent radiation resistance of AlN microwires and UV resistance of silica fibers, the proposed device is expected to have the good stability and potential applications in the fields of the solar physics and space exploration.
HPV-driven oncogenesis—much more than the E6 and E7 oncoproteins
Authors: Janiszewska J. , Kostrzewska-Poczekaj M. , Wierzbicka M. , Brenner J. C. , Giefing M. 
Published: June 2024

Abstract
High-risk human papillomaviruses are well-established drivers of several cancer types including cervical, head and neck, penile as well as anal cancers. While the E6 and E7 viral oncoproteins have proven to be critical for malignant transformation, evidence is also beginning to emerge suggesting that both host pathways and additional viral genes may also be pivotal for malignant transformation. Here, we focus on the role of host APOBEC genes, which have an important role in molecular editing including in the response to the viral DNA and their role in HPV-driven carcinogenesis. Further, we also discuss data developed suggesting the existence of HPV-derived miRNAs in HPV + tumors and their potential role in regulating the host transcriptome. Collectively, while recent advances in these two areas have added complexity to the working model of papillomavirus-induced oncogenesis, these discoveries have also shed a light onto new areas of research that will be required to fully understand the process.
School is not enough: The role of climate-specific knowledge for transformative climate policy and economic system preferences
Authors: Eichhorn Jan , Thomet Julian , Solaz Andrea Gimeno 
Published: June 2024

AbstractDespite risen awareness of human-made climate change, there are still gaps in knowledge about the precise nature and the impact of the climate crisis for many people. This paper investigates to what extent factual knowledge about climate change is linked to publics’ policy preferences regarding climate crisis measures. It expands on existing research by widening the focus beyond climate-specific policy and also investigates whether knowledge about the crisis is connected to preferences for greater state involvement in the economy structurally. Comparing representative survey results from eight European countries and the USA, this paper shows that climate-specific knowledge is indeed strongly linked to both—while greater formal education does not show strong associations or is even linked to a preference for the status quo in some countries. Important cross-country variations and the implications of emphasising climate specific knowledge in advocacy and policy contexts are discussed to demonstrate how enhancing public knowledge could increase support for transformative climate policies and broader economic change.
A minimal free resolution of the duplication of a monomial ideal
Authors: Valencia Carlos E. , Molano David C. , Moreno Javier A. 
Published: June 2024

AbstractThis article explores a novel operation of a monomial ideal, termed duplication, which produces a monomial ideal $$I^\diamond $$

I
⋄

from another I. This operation is inspired by and generalizes how vertex duplication affects the edge ideal of a graph. The main result describes a multigraded minimal free resolution of $$I^\diamond $$

I
⋄

as long as we know a resolution for I. Consequently, we obtain formulas for the projective dimension and depth of $$I^\diamond $$

I
⋄

in terms of the corresponding invariants of I.
Stability and synchronization of octonion-valued neural networks with leakage and mixed delays on time scales
Authors: Popa Călin-Adrian 
Published: June 2024

AbstractThere has been a great deal of interest in the last few years for neural networks (NNs) with values in multidimensional domains. The most popular models are complex-valued neural networks (CVNNs), followed by quaternion-valued neural networks (QVNNs), and, more recently, by Clifford-valued neural networks (ClVNNs). However, also very recently, a different type of NNs were put forward, namely octonion-valued neural networks (OVNNs). OVNNs are defined on the 8D octonion algebra, and they are not a special type of ClVNNs, because Clifford numbers are associative, whereas octonions are not. Moreover, beside the complex and quaternion algebras, the only other normed division algebra over the reals is the algebra of octonions, which makes OVNNs a direct generalization of CVNNs and QVNNs from this point of view, raising interest for applications handling high-dimensional data. On the other hand, systems defined on time scales were proposed as a generalization of both discrete time and continuous time systems, or any type of hybrid combination between the two. Finally, time delays appear as a consequence of implementing NNs in real life circuits. Taking all these into consideration, this paper studies the fundamental properties of exponential stability and exponential synchronization for OVNNs with leakage and mixed delays defined on time scales. In order to avoid the problems raised by the non-associativity of the octonion algebra, the OVNN model is decomposed into a real-valued one. Then, two different Lyapunov-type functionals are defined and the particularities of time scale calculus are used in order to deduce sufficient conditions expressed as scalar and linear matrix inequalities (LMIs) for the exponential stability of the proposed models, based on Halanay-type inequalities suitable for time scale systems. Afterwards, a state feedback controller is used to deduce sufficient criteria given as scalar inequalities and LMIs for the exponential synchronization of the same type of models. The generality of the model, given by the definition on the algebra of octonions, the use of different types of delays, and the definition on time scales represent an important advantage. Also, for less general models, it is possible to particularize the obtained results. With the aim to demonstrate each of the paper’s four theorems, four numerical examples are provided.
Biochemical liver damage during gender affirming therapy in trans adults assigned female at birth: a meta-analysis
Authors: Tienforti D. , Savignano G. , Spagnolo L. , Di Giulio F. , Baroni M. G. , Barbonetti A. 
Published: June 2024

Abstract

Purpose
To assess the effects of testosterone (T)-based gender affirming hormone therapy (GAHT) on liver blood tests (LBTs) in assigned female at birth adults, using a meta-analytic approach.

Methods
Prospective and retrospective studies were selected that reported the prevalence of biochemical liver damage (BLD) and LBTs changes during T therapy. Data collected included pre-and-during therapy alanine-aminotransferase (ALT), aspartate-aminotransferase (AST), gamma-glutamyl-transferase (GGT), and alkaline phosphatase (ALP) mean concentration values.

Results
The prevalence of BLD in 14 studies on 1698 subjects was 1% (95% CI 0.00–3.00; I2 = 14.1%; p = 0.82). In 17 studies on 2758 subjects, GAHT was associated with a statistically (but not clinically) significant increase in AST, GGT and ALP at 12 months and ALT at 3–7 (MD: 1.19 IU/l; 95% CI 0.31, 2.08; I2: 0%), at 12 (MD: 2.31 IU/l; 95% CI 1.41, 3.21; I2: 29%), but with no more significant increase at 24 months (MD: 1.71 IU/l; 95% CI −0.02, 3.44; I2: 0%).

Conclusions
Analysis of aggregate estimates confirms a low risk of BLD and abnormalities in LBTs, transient in most cases, during T-based GAHT, thus suggesting a limited need for careful liver monitoring in AFAB people.