bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unique Protein Signature of Circulating Microparticles in Systemic Lupus Erythematosus
Authors: Østergaard Ole , Nielsen Christoffer T. , Iversen Line V. , Tanassi Julia T. , Knudsen Steen , Jacobsen Søren , Heegaard Niels H. H. 
Published: July 2013

ObjectiveTo characterize the unique qualities of proteins associated with circulating subcellular material in systemic lupus erythematosus (SLE) patients compared with healthy controls and patients with other chronic autoimmune diseases.MethodsUsing differential centrifugation and high‐sensitivity nano–liquid chromatography tandem mass spectrometry, we systematically profiled proteins of microparticles (MPs) from SLE patients (n = 12), systemic sclerosis (SSc) patients (n = 6), and rheumatoid arthritis (RA) patients (n = 6), as well as healthy controls (n = 12).ResultsWe identified 531 unique proteins and showed that the differences between healthy controls and patients with SLE with regard to the abundance of 248 proteins were highly statistically significant. Almost half of the proteins that were increased by >2‐fold were complement proteins and Ig (increased by 100–4,000 times). MP Ig and complement loads also distinguished SLE from RA and SSc and correlated strongly with clinical SLE severity. Subsets of microtubule proteins, fibronectin, 14‐3‐3η, and desmosomal proteins as well as ficolin 2 and galectin 3 binding protein were also highly increased. In SLE MPs, levels of cytoskeletal, mitochondrial, and organelle proteins, including lysosome‐associated membrane protein 1 and transforming growth factor β1, were decreased.ConclusionThe data show that SLE patients have increased numbers of MPs that are heavily tagged for removal and fewer MPs with normal protein composition. SLE MPs are unique and specific proteins that represent novel leads for our understanding of SLE and for the development of new treatments of the disease.
Sputum Autoantibodies in Patients With Established Rheumatoid Arthritis and Subjects at Risk of Future Clinically Apparent Disease
Authors: Willis Van C. , Demoruelle M. Kristen , Derber Lezlie A. , Chartier‐Logan Catherine J. , Parish Mark C. , Pedraza Isabel F. , Weisman Michael H. , Norris Jill M. , Holers V. Michael , Deane Kevin D. 
Published: July 2013

ObjectiveTo evaluate the generation of rheumatoid arthritis (RA)–related autoantibodies in the lung.MethodsSimultaneous collection of serum and induced sputum was performed in 21 healthy controls, 49 at‐risk subjects without inflammatory arthritis but at risk of RA due to family history or seropositivity for anti–citrullinated protein antibodies, and 14 subjects with early RA. Samples were tested for anti–cyclic citrullinated peptide 2 (anti‐CCP2), anti‐CCP3, anti‐CCP3.1, rheumatoid factor isotypes IgM, IgG, and IgA, and total IgM, IgG, and IgA.ResultsOne or more autoantibodies were present in sputum of 39% of at‐risk seronegative subjects, 65% of at‐risk seropositive subjects, and 86% of subjects with early RA. In at‐risk seronegative subjects, the rate of anti‐CCP3.1 positivity and the median number of autoantibodies were elevated in sputum versus serum. In subjects with early RA, the rate of positivity for several individual autoantibodies and the median number of autoantibodies were higher in serum than in sputum. Results in at‐risk seropositive subjects were intermediate between these groups. In at‐risk subjects with autoantibody positivity in sputum, the ratios of autoantibody to total Ig were higher in sputum than in serum, suggesting that these autoantibodies are generated or sequestered in the lung.ConclusionRA‐related autoantibodies are detectable in sputum in subjects at risk of RA and in subjects with early RA. In a subset of at‐risk subjects, the presence of sputum autoantibodies in the absence of seropositivity, and the increased autoantibody‐to–total Ig ratios in sputum, suggest that the lung may be a site of autoantibody generation in the early development of RA. These findings suggest an important role of the lung in the pathogenesis of RA.
Brief Report: Accelerated Aging Influences Cardiovascular Disease Risk in Rheumatoid Arthritis
Authors: Crowson Cynthia S. , Therneau Terry M. , Davis John M. , Roger Véronique L. , Matteson Eric L. , Gabriel Sherine E. 
Published: July 2013

ObjectiveTo determine whether the impact of aging on cardiovascular disease (CVD) risk in patients with rheumatoid arthritis (RA) differs from that in the general population (as estimated by the Framingham Risk Score [FRS]).MethodsA population‐based inception cohort of Olmsted County, Minnesota residents ages ≥30 years who fulfilled the American College of Rheumatology 1987 criteria for RA in 1988–2008 was assembled and followed up until death, migration, or July 1, 2012. Data on CVD events were collected by medical records review. The 10‐year FRS for CVD was calculated. Cox models adjusted for FRS were used to examine the influence of age on CVD risk.ResultsThe study included 563 patients with RA without prior CVD (mean age 55 years, 72% women, and 69% seropositive [i.e., rheumatoid factor and/or anti–citrullinated protein antibody positive]). During a mean followup of 8.2 years, 98 patients developed CVD (74 seropositive and 24 seronegative), but the FRS predicted only 59.7 events (35.4 seropositive and 24.3 seronegative). The gap between observed and predicted CVD risk increased exponentially across age, and the effect of age on CVD risk in seropositive RA was nearly double its effect in the general population, with additional log(age) coefficients of 2.91 for women (P = 0.002) and 2.06 for men (P = 0.027).ConclusionOur findings indicate that age exerts an exponentially increasing effect on CVD risk in seropositive RA, but no increased effect among seronegative patients. The causes of accelerated aging in patients with seropositive RA deserve further investigation.
Wärmetechnische Besonderheiten von Membrankissenkonstruktionen
Authors: Kaufmann Andreas , Sedlbauer Klaus , Sieder Mike 
Published: July 2013

AbstractMembrankonstruktionen werden in der modernen Architektur zunehmend als Dach‐ und Fassadenkonstruktion eingesetzt. Besonders ETFE‐Folien (Ethylen‐Tetrafluorethylen) eignen sich aufgrund ihrer hohen Transparenz und ihres geringen Gewichts als Substitut für Glas, wenn es darum geht, große Flächen freitragend und transparent zu überspannen.Gerade in jüngerer Zeit werden durch prestigeträchtige Bauten, wie die Allianz‐Arena in München (Bild 1), Membranen auch in der Öffentlichkeit vermehrt als eigenständiger Baustoff wahrgenommen, mit dem sich vollständige Gebäudefassaden realisieren lassen. Neben offenen Anlagen, wie Fußball‐Arenen, werden aber auch zunehmend geschlossene Gebäude mit Membrankissen‐Hüllen realisiert. Ein bekanntes Beispiel dafür ist der sogenannte “Water Cube” – das National Aquatics Center in Peking, das anlässlich der Olympischen Spiele 2008 errichtet wurde. Der steigende Markterfolg ist vor allem dem neuartigen und optisch ansprechenden Charakter sowie dem geringen Gewicht solcher Konstruktionen zuzuschreiben.Bei allen Vorteilen, die der konstruktive Membranbau mit transparenten Folienkissen bietet, sind noch zahlreiche bauphysikalische Fragen ungeklärt. Insbesondere für eine fundierte und gesicherte wärmetechnische Beurteilung fehlen bislang angepasste Bemessungsverfahren und normative Festlegungen, die den Besonderheiten von Membrankonstruktionen Rechnung tragen. Für die geforderten Nachweise werden deshalb meist Prüfverfahren und Vorschriften aus anderen Baubereichen herangezogen, die oft nicht oder nicht ausreichend dafür geeignet sind.Thermo‐technical characteristics of membrane cushion constructionsMembrane structures are increasingly used in modern architecture as a roof and facade construction. Especially ETFE foils (ethylene‐tetrafluoroethylene) are suitable as a substitute for glass to span large areas due to their high transparency and low weight.Particularly in recent times, due to prestigious buildings, such as the Allianz‐Arena in Munich (Fig. 1), membranes are increasingly perceived as a separate building material to realize full building facades. Apart from open buildings, such as football stadiums, more and more closed buildings are realized with membrane cushion covers. A well‐known example is the so‐called “Water Cube” – the National Aquatics Center in Peking, which was built for the 2008 Olympic Games. The increasing market success can be attributed mainly to the novel and visually appealing character and the light weight of such constructions.In spite of all the benefits that such membrane constructions provides, numerous building physical questions remain still unanswered. Especially for a basic and reliable heat‐technical assessment adapted design methods and standards are missing, which take the specific characteristics of membrane structures into account. For required proof tests therefore procedures and standards are used from other construction areas, which are often not suitable or not sufficient for it.
Heterologous prime‐boost immunization regimens using adenovirus vector and virus‐like particles induce broadly neutralizing antibodies against H5N1 avian influenza viruses
Authors: Lin Shih‐Chang , Liu Wen‐Chun , Lin Yu‐Fen , Huang Yu‐Hsuan , Liu Jin‐Hwang , Wu Suh‐Chin 
Published: July 2013

AbstractHighly pathogenic avian influenza (HPAI) H5N1 viruses continue to trigger severe diseases in poultry and humans, prompting efforts to develop an effective vaccine. Toward that goal, we constructed a recombinant adenovirus vector encoding influenza hemagglutin (rAd‐HA) and a flagellin‐containing virus‐like particle (FliC‐VLP). Using a murine model, we investigated a heterologous prime‐boost vaccination regimen combining these two vectors. Our results indicate that priming with the rAd‐HA vector followed by a FliC‐VLP booster induced the highest HA‐specific total IgG, IgG1and IgG2a. Maximum neutralizing antibody titers against homologous and heterologous clades of H5N1 virus strains and hemagglutination inhibition resulted from the heterologous vaccination strategy. Our results are likely to contribute to the development of more effective H5N1 vaccines.
Screening and determination for potential α‐glucosidase inhibitory constituents from Dalbergia odorifera T. Chen using ultrafiltration‐LC/ESI‐MSn
Authors: Zhao Chunfang , Liu Yongqiang , Cong Dengli , Zhang Hui , Yu Jiajia , Jiang Ying , Cui Xiuyue , Sun Jiaming 
Published: July 2013

ABSTRACTIn the present study, it was demonstrated that ethyl acetate soluble fraction partitioned from heartwood of Dalbergia odorifera T. Chen (HEF) had a remarkable inhibitory effect on α‐glucosidase. Therefore HEF was selected as a starting material for screening the potential α‐glucosidase inhibitors using ultrafiltration liquid chromatography/mass spectrometry (UF‐LC/MS). Twenty‐six compounds were identified with analysis of LC/MS. UF assay indicated that 18 compositions might be α‐glucosidase inhibitors in HEF; eight of them were estimated for their α‐glucosidase inhibitory activity, and the results showed that (2S)‐liquiritigenin, (2S)‐4′,6‐dihydroxy‐ 7‐methoxyflavanone and isoliquiritigenin displayed obvious inhibition of yeast α‐glucosidase. In addition, in order to control the quality of HEF, the content of five compounds in HEF was simultaneously determined for the first time. These results provide an important theoretical base for the further application of HEF to treat type 2 diabetes in the clinic and development of natural α‐glucosidase inhibitors with low toxicity. Copyright © 2013 John Wiley & Sons, Ltd.
An Examination of Corporate Social Responsibility Implementation and Stakeholder Engagement: A Case Study in the Australian Mining Industry
Authors: Dobele Angela R. , Westberg Kate , Steel Marion , Flowers Kris 
Published: July 2013

ABSTRACTThis case study explores the experience of a company in a controversial industry sector and its efforts to act in a socially responsible manner when establishing a presence in a regional market. We examine the management of stakeholder relationships and communication, and identify the challenges associated with implementing corporate social responsibility (CSR) initiatives. Our findings highlight the importance of ongoing and broad stakeholder identification, prioritization and management. This case study demonstrates the key role of commitment from senior management and front‐line employees and the importance of a CSR champion. Commitment must be demonstrated at a local level to facilitate community engagement, feedback and monitoring. Finally, the findings highlight the externality of stakeholder networks and their non‐centric relationship with the company. Thus, a company is not the centre of the stakeholder network; the network has a life of its own, regardless of a company's involvement or non‐involvement. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment.
Modeling and Assessing Sustainable Enterprise Excellence
Authors: Edgeman Rick , Eskildsen Jacob 
Published: July 2013

ABSTRACTThe enterprise excellence and modern sustainability movements have developed along near parallel timelines. Skilled use of enterprise excellence systems has been documented to significantly boost performance across an array of key domains, including financial, human capital, operations and supply chain, and other areas. Notably absent are social and environmental performance, with their absence attributable to the inadequate emphasis on enterprise excellence of these domains. Similarly, although the triple bottom line is core to the sustainability movement, many adherents of sustainability approach its people and planet domains with ardor, yet virtually neglect its profit domain. A simple model of sustainable enterprise excellence and accompanying maturity assessment regimen are introduced and advanced as a means of merging these movements to drive an equity, ecology and economy triple top line strategy to produce triple bottom line people, planet and profit performance with innovation and organizational design playing pivotal roles in both the model and its assessment. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment
A Business Sustainability Model for Government Corporations. A Belgian Case Study
Authors: Benijts Tim 
Published: July 2013

ABSTRACTA government's decision to tackle societal non‐sustainability problems by setting up a government corporation also necessitates the choice of a business model. This article seeks to contribute to this debate through an analysis of the (linkages between the key elements of the) business model of the Kringloopfonds (TKF), a Belgian government corporation set up in order to provide finance to sustainable companies. Based on documentary information and semi‐structured interviews with stakeholders TKF's business model is reconstructed which next is evaluated by means of program theory. It was found that TKF's portfolio allocation rule did not foresee in sufficient flexibility in order to cope with the shortage in financeable companies TKF was confronted with. This case thereby advocates for more business model flexibility in terms of portfolio allocation rules, time and asset requirements as well as for thorough sensitivity analyses testing business model's resistance to an initial and temporary shortage of sustainable companies. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment.
Environmental, Social and Governance Reporting in China
Authors: Weber Olaf 
Published: July 2013

ABSTRACTWhat is the current state of environmental, social and governance (ESG) reporting and what is the relation between ESG reporting and the financial performance of Chinese companies? This study analyses corporate ESG disclosure in China between 2005 and 2012 by analysing the members of the main indexes of the biggest Chinese stock exchanges. After discussing theories that explain the ESG performance of firms such as institutional theory, accountability and stakeholder theory we present uni‐ and multivariate statistical analyses of ESG reporting and its relation to environmental and financial performance. Our results suggest that ownership status and membership of certain stock exchanges influence the frequency of ESG disclosure. In turn, ESG reporting influences both environmental and financial performance. We conclude that the main driver for ESG disclosure is accountability and that Chinese corporations are catching up with respect to the frequency of ESG reporting as well as with respect to the quality. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment
Sustainable Tuna – Can the Marketplace Improve Fishery Management?
Authors: Leadbitter Duncan , Benguerel Rene 
Published: July 2013

ABSTRACTTuna is a major global seafood commodity and thus of significance to retailers in most countries, but especially in countries consuming large quantities of canned tuna such as the United Kingdom, United States and many European countries. Some key species are under heavy fishing pressure, and companies realize that without conservation oriented management their future supplies may be in jeopardy.Sustainable sourcing policies are becoming an integral part of supply chains for seafood products. Under the influence of public opinion bodies such as the media and environmental NGOs, many retailers have adopted seafood sourcing policies in the past decade.The business strategy of any particular company in seeking to support sustainable fishing can vary, but may include the pursuit of market opportunities, protection from damaging publicity and corporate social responsibility commitments. Companies that seek to involve themselves in fishery sustainability issues need to be committed to broad based partnerships with other companies and NGOs, and transparency about all aspects of their decision making, intentions and progress.The sustainable seafood movement has proven persistent and adaptable, and this is increasing the number of retailers seeking sustainable tuna. In a demand driven market economy this growth will surely be influential. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment
Stakeholder Engagement and Sustainable Corporate Community Investment
Authors: Rowe Anna Lee , Nowak Margaret , Quaddus Mohammed , Naude Marita 
Published: July 2013

ABSTRACTThis paper presents the findings of research exploring the value and impacts of corporate community investment (CCI) through community partnerships. The research considered the community partners' perceptions of the value and impact of CCI. We adopted an inquiry paradigm utilising constructivist ontology, interpretivist epistemology and a case study method. In dialogue with Wesfarmers Ltd's community partners, the ‘realities’ presented by these beneficiary stakeholders were interpreted and understood (verstehen).While the CCI programmes with each of the not‐for‐profit organisations had different objectives, we were able to classify, under broad headings, the nature of the benefits to the community. One question highlighted is whether all corporate investing is the same? We found two aspects to this: the strategic fit for the community organisation of proposed investment and whether the corporate partner sought a relational as opposed to transactional approach to funding provision. Recommendations can be made for the funding structure deemed to be most effective from the community partners' perspectives. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment
Corporate Sustainability and Economic Performance: an Empirical Analysis of a Voluntary Environmental Program in the USA
Authors: Moon Seong‐gin , Bae Suho , Jeong Moon‐Gi 
Published: July 2013

ABSTRACTVoluntary environmental programs (VEPs) are designed based on a win–win approach to environmental protection that reconciles environmental protection and economic performance. Despite the claims about VEPs, there has been an ongoing debate over their efficacy with regard to whether environmental goals are balanced by economic interests on both theoretical and empirical grounds. To resolve this controversy, this paper empirically investigates a public VEP by the US Environmental Protection Agency: Green Lights (GL). For this, the paper constructs a treatment effects regression model to account for the effects of non‐random assignment for GL participants and non‐participants. The proposed model can simultaneously estimate probit models that predict corporate participation in the GL program and linear models that test the extent to which this participation contributes to economic performance. The results indicate significant positive effects of corporate participation in the GL program on economic performance, providing support for the win–win perspective. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment
Exploring Pretreatment–Morphology Relationships: Ab Initio Wulff Construction for RuO2 Nanoparticles under Oxidising Conditions
Authors: Wang Tongyu , Jelic Jelena , Rosenthal Dirk , Reuter Karsten 
Published: July 2013

AbstractWe present a DFT‐based Wulff construction of the equilibrium shape of RuO2 particles in an oxygen environment. The obtained intricate variations in the crystal habit with the oxygen chemical potential allow for a detailed discussion of the dependence on the oxidising pretreatment used in recent powder catalyst studies. The analysis specifically indicates an incomplete particle shape equilibration in previously used low‐temperature calcination. Equilibrated particles could be active CO oxidation catalysts with long‐term stability in oxidising feed and then represent an interesting alternative to the previously suggested core–shell concept.
ChemInform Abstract: K and Ba Distribution in the Structures of the Clathrate Compounds KxBa16‐x(Ga,Sn)136 (x = 0.8, 4.4, and 12.9) and KxBa8‐x(Ga,Sn)46 (x = 0.3).
Authors: Schaefer Marion C. , Bobev Svilen 
Published: July 2013

AbstractThe title compounds are prepared from mixtures of the elements (823 K, 15 h).
ChemInform Abstract: MgSO4·11H2O and MgCrO4·11H2O Based on Time‐of‐Flight Neutron Single‐Crystal Laue Data.
Authors: Fortes A Dominic , Wood Ian G. , Gutmann Matthias J. 
Published: July 2013

AbstractThe crystal structures of the title compounds are determined by single crystal neutron time‐of‐flight measurements.
ChemInform Abstract: Fe2 (SO4) 3·H2SO4·28H2O, a Low‐Temperature Water‐Rich Iron(III) Sulfate.
Authors: Schmidt Horst , Hennings Erik , Zuerner Philipp , Voigt Wolfgang 
Published: July 2013

AbstractViolet crystals of the title compound are obtained from aqueous solutions of Fe2(SO4)3 containing 5—20% H2SO4 (235—239 K).
ChemInform Abstract: A Trigonal‐Prismatic Hexanuclear Technetium(II) Bromide Cluster: Solid‐State Synthesis and Crystallographic and Electronic Structure.
Authors: Johnstone Erik V. , Grant Daniel J. , Poineau Frederic , Fox Laura , Forster Paul M. , Ma Longzou , Gagliardi Laura , Czerwinski Kenneth R. , Sattelberger Alfred P. 
Published: July 2013

AbstractNa{[Tc6Br12]2Br} is obtained by thermal decomposition of TcBr4 (Na source not given; evacuated Pyrex ampule, 1.
ChemInform Abstract: Cs2GeB4O9: A New Second‐Order Nonlinear‐Optical Crystal.
Authors: Xu Xiang , Hu Chun‐Li , Kong Fang , Zhang Jian‐Han , Mao Jiang‐Gao , Sun Junliang 
Published: July 2013

AbstractPolycrystalline Cs2GeB4O9 samples are obtained by solid state reaction of a stoichiometric mixture of Cs2CO3, GeO2, and H3BO3 (Pt crucible, 1.
ChemInform Abstract: Crystal Growth, Structure, Polarization, and Magnetic Properties of Cesium Vanadate, Cs2V3O8: A Structure—Property Study.
Authors: Yeon Jeongho , Sefat Athena S. , Tran T. Thao , Halasyamani P. Shiv , zur Loye Hans‐Conrad 
Published: July 2013

AbstractSingle crystals of Cs2V3O8 are synthesized via a two‐step hydrothermal route starting with an aqueous solution of V2O5 and oxalic acid (autoclave, 150 °C, 12 h) followed by addition of Cs2CO3 (150 °C, 24 h; 91% yield).