bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skin Is the Frequent Site for Involvement of Peripheral T‐Cell and Natural Killer Cell Lymphomas in Korea
Authors: Cho Kwang‐Hyun , Choi Won‐Woo , Youn Choon‐Shik , Kim Chul‐Woo , Heo Dae‐Seog 
Published: April 2015

AbstractWe have studied the clinicopathological features of 19 Korean cases of peripheral T‐cell and natural killer (NK) cell lymphomas, not including mycosis fungoides. Primary cutaneous involvement was demonstrated in eight of these 19 cases, and we recognized four clinicopathologic subtypes among these eight patients: nasal type NK/T cell lymphoma, three cases; primary cutaneous CD30 positive anaplastic large cell lymphoma, two cases; subcutaneous panniculitis‐like T‐cell lymphoma, one case; lymphoma with hydroa vacciniforme‐like cutaneous lesions, two cases. We did not, however, encounter any cases of HTLV‐associated adult T‐cell lymphoma/leukemia, which is common in Taiwan and Japan. EBV‐associated lymphoma is the most prominent type of peripheral T‐cell and NK cell neoplasm involving the skin in Korea.
Correlation between Propionibacterium acnes Biotypes, Lipase Activity and Rash Degree in Acne Patients
Authors: Higaki Shuichi , Kitagawa Taro , Kagoura Masayori , Morohashi Masaaki , Yamagishi Takayoshi 
Published: April 2015

AbstractWe examined the possible correlation between biotypes of Propionibacterium acnes, lipase activity, and rash degree in acne patients. Among 5 P. acnes biotypes, P. acnes biotype 3 (B3) was the most common, followed by P. acnes biotypes 1, 2 and 4; P. acnes biotype 5 was not found. P. acnes B3 was isolated from more severe skin rashes than those of the other biotypes. Production of propionic acid (PA) and butyric acid (BA) by P. acnes B3 was higher than those by the other P. acnes biotypes. As the rash degree in acne patients was more severe, the production of PA and BA elevated. Although only a few P. acnes strains were examined in the present study, P. acnes B3 had the highest lipase activity and might have the greatest influence on skin rash in acne patients.
A Case of Pyoderma Gangrenosum on the Stump of an Amputated Right Leg
Authors: Umezawa Yoshinori , Oyake Shinichi , Oh‐i Tsunao , Nagae Tsuneyuki , Ishimaru Shin 
Published: April 2015

AbstractWe present here a case of pyoderma gangrenosum (PG) on the stump of an amputated leg. The patient was a 69‐year‐old woman who had both of her legs amputated due to acute arterial occlusion. An ulcer first appeared nine years later, after which point it continued to fluctuate in size. Complications included regional blood flow disorder at the amputated stump, diabetes, and secondary infection. Despite various therapies, the ulcer exacerbated, and hypoproteinemia, increased CRP, and fever were confirmed. The patient was diagnosed as having PG based on her clinical symptoms and because the ulcer did not respond to various therapies. The ulcer improved significantly in response to administration of 40 mg/day of prednisolone, and complete epithelialization was later achieved. Given the presence of multiple complications, it was extremely difficult to confirm PG. Therefore, it is important for physicians to consider PG as one of the causes of intractable ulcers.
The Relationship between Angioblastoma (Nakagawa) and Tufted Angioma: Report of Four Cases with Angioblastoma and a Literature‐Based Comparison of the Two Conditions
Authors: Igarashi Masaru , Oh‐i Tsunao , Koga Michiyuki 
Published: April 2015

AbstractWe report four recent cases of angioblastoma (Nakagawa). Histopathologic examinations of all cases revealed dispersed islets of clear marginal lobules of varying sizes in the dermis. Neoplastic endothelioid cells with moderate atypia and enlarged capillaries containing erythrocytes were found in the conglomerates. Recently, the features of this disease have been compared to the tufted angioma that has been reported in Europe and the U.S. Our evaluation suggests that these two diseases are very likely the same. We suggest that this disease should be called “angioblastoma” in agreement with the first report of this disease by Nakagawa.
A Case of Hypopigmented Mycosis Fungoides
Authors: Choe Yong Boem , Park Kyoung Chan , Cho Kwang Hyun 
Published: April 2015

AbstractWe experienced a 26‐year‐old woman in whom widespread hypopigmented macules and patches developed as the initial clinical feature of mycosis fungoides. Histopathological examination confirmed the diagnosis. The patient was treated with PUVA, and the lesion progressively disappeared within five months.
Olmsted Syndrome: Report of Two New Cases and Literature Review
Authors: Larrègue Marc , Callot Valérie , Kanitakis Jean , Suau A. Montis , Foret Murielle 
Published: April 2015

AbstractOlmsted syndrome is a rare keratinization disorder; 18 cases have been published so far. It associates a mutilating congenital palmoplantar keratoderma with periorificial erythematokeratotic lesions. We report herein two new unrelated male children with Olmsted syndrome (OS), one of whom was studied by light and electronmicroscopy. Our histological, immunohistochemical, and ultrastructural findings suggest that this disease is related to epidermal hyperproliferation. We present herein a review of the twenty cases published so far and discuss the major clinicopathological and genetic features of this disease.
Is Renal Function Altered in Patients with Psoriasis Vulgaris?—A Short Review
Authors: Szepietowski Jacek C , Szepietowski Tomasz 
Published: April 2015

AbstractPsoriasis is a chronic inflammatory dermatosis with distinct microvascular changes. Although it is generally accepted that the psoriatic process is limited to the skin, it is not excluded that similar vascular lesions might be present in internal organs, such as the kidneys. This review summarizes data on renal function in psoriatic patients who were never treated with the potentially nephrotoxic drugs used for treatment of psoriasis. The limited number of such studies is mainly concentrated on microalbuminura. Enhanced urinary albumin excretion at the level of microalbuminuria has been found in some psoriatic individuals. All other routine laboratory renal tests were within their normal ranges. As microalbuminuria is regarded as a subclinical marker of glomerular dysfunction, the authors hypothesize that some psoriatic patients may present subclinical glomerular changes. However, kidney histopathology is necessary to confirm this hypothesis.
A Case of Dowling‐Degos Disease Suggesting an Evolutional Sequence
Authors: Lee Seok Jong , Lee Hyun Joo , Kim Do Won , Jun Jae Bok , Chung Sang Lip , Bae Han Ik 
Published: April 2015

AbstractWe report a 47‐year‐old woman who presented with asymptomatic reticulate hyperpigmentations on the neck, lateral face, axillae, trunk, inguinal areas, and dorsa of both hands and feet. We thought it was an unusual case in the spectrum between the pole of Dowling‐Degos disease (DDD) and that of reticulate acropigmentation of Kitamura (RAK). Another interesting point was that the biopsied specimens from the abdomen, neck, and axillary lesions showed somewhat different histopathologic features from typical DDD, suggesting an evolutional sequence. From these findings we suggest that a lichenoid inflammation may be responsible for the typical maculo‐papular lesions of DDD.
Acrodermatitis Enteropathica‐like Eruption in an Infant with Nonketotic Hyperglycinemia
Authors: Samady Joseph A. , Schwartz Robert A. , Shih Ling Yu , Piela Zofia , Lambert W. Clark , Janniger Camila K. 
Published: April 2015

AbstractAcrodermatitis enteropathica is a rare inherited disorder characterized by zinc deficiency and a triad of dermatitis, diarrhea, and alopecia. It is an autosomal recessive condition thought to be due to the inability to absorb zinc from the gastrointestinal tract. Acquired zinc deficiency due to a variety of etiologies may produce a similar clinical picture. These causes include inadequate supply, malabsorption, and low zinc stores. In addition to zinc, deficiencies of other nutrients such as branched chain amino acids have induced an acrodermatitis enteropathica‐like eruption. We describe a case of a 26‐month‐old boy with a rare inborn error of metabolism known as nonketotic hyperglycinemia who developed an acrodermatitis enteropathica‐like eruption. In addition to zinc deficiency, the patient was deficient in branched chain amino acids due to a low protein diet instituted to reduce his elevated glycine levels. The rash did not respond to zinc replacement alone, and therefore is most likely a combination of amino acid and zinc deficiency. Acrodermatitis enteropathica‐like eruptions have been described in other conditions that cause decreased serum amino acids, such as maple syrup urine disease and organic acidurias. This is the first case describing an association between acrodermatitis enteropathica and nonketotic hyperglycinemia.
Three Unusual Siblings with Harlequin Icthyosis in an Indian Family
Authors: Sarkar Rashmi , Sharma Ravi C. , Sethi Seema , Basu Srikanta , Das Rupam , Mendiratta Vibhu , Sardana Kabir , Kakar Nirupma 
Published: April 2015

AbstractHarlequin fetuses occurring as three siblings in an Indian family are described here. All three were preterm, low birth weight, and did not survive. There was no history of consanguinous marriage in the parents or in the family. Thus autosomal recessive inheritence appears to be a remote possibility, although not impossible or, as recently described, these recurrent harlequin fetuses could be the result of new dominant mutations with parental mosaicism.
Eruptive Vellus Hair Cyst and Epidermoid Cyst in a Patient with Pachyonychia Congenita
Authors: Takeshita Taizo , Takeshita Hiromichi , Irie Koji 
Published: April 2015

AbstractWe report the first case of pachyonychia congenita (PC) associated with both eruptive vellus hair cyst (EVHC) and epidermoid cyst. The patient is a 12‐year‐old Japanese girl who presented with two natal teeth at birth. She had thickening and discoloration of the fingernails and toenails, plantar hyperkeratosis, palmar‐plantar hyperhidrosis and multiple cutaneous cysts. Histologic examination revealed EVHC and epidermoid cyst.
A Case of Subcorneal Pustular Dermatosis Treated with Tacalcitol (1α,24‐Dihydroxyvitamin D3)
Authors: Kawaguchi Masakazu , Mitsuhashi Yoshihiko , Kondo Shigeo 
Published: April 2015

AbstractWe report a case of subcorneal pustular dermatosis (SPD) treated with tacalcitol (1α,24‐Dihydroxyvitamin D3) ointment. A 77‐year‐old male had had asymptomatic, superficial, grouped pustules in annular patterns with mild background erythema for six years which affected his axillae and bilateral groin. A diagnosis of SPD was made. Topical vitamin D3 (tacalcitol) was applied to the lesion of SPD and its clinical effectiveness was assessed. Within one month, symptoms in the lesion treated with tacalcitol ointment started subsiding, and eventually only erythema remained. After three months, the region treated with tacalcitol ointment showed no relapse. We conclude that tacalcitol ointment is effective for SPD in some case.
The Antibacterial Activity of Tea In vitro and In vivo (In Patients with Impetigo Contagiosa)
Authors: Sharquie Khalifa E. , AL‐Turfi Ihsan A. , AL‐Salloum Suhaila M. 
Published: April 2015

AbstractA total number of 104 patients with impetigo contagiosa was included in this study. They were 47 females (45.2%) and 57 males (54.8%). Their ages ranged from one month to 40 years with a median of 4 years. This study was divided into two parts:Part I (in vitro): Thirty‐five patients were swabbed to determine the microbiology of impetigo contagiosa which included 33 isolates of pure S. aureus (94.3%) and 2 of a combination of S. aureus and Streptococcus pyogenes (5.7%). The antibacterial effect of tea liquor (lotion) against S. aureus proved very effective. Antibiotic sensitivity was done for all bacterial isolates of S. aureus.Part II (in vivo): The antibacterial effects of tea liquor and ointment were tested by treating 64 patients with impetigo contagiosa. Tea ointment was very effective with a cure rate of 81.3%. Forty patients were taken as controls and divided into two groups. The first one was given an ointment containing Framycetin and gramicidin (soframycin) with a cure rate of 72.2%; the other group was given oral cephalexin with a cure rate of 78.6%. To the best of our knowledge, this study was the first one which demonstrated the anti‐bacterial action of crude tea in vivo, against impetigo contagiosa. Clinical data about impetigo are also included in this study.
Evaluation on the Occurrence of Tsutsugamushi Disease in Tottori Prefecture
Authors: Rivera Ma. Rosario P. , Mihara Motoyuki , Shibata Michiyo 
Published: April 2015

AbstractIn Tottori Prefecture, we gathered the data of all patients known to have been infected with tsutsugamushi disease (TD) over a span of 49 years, from 1950 to 1998. The total number of patients reported so far has been 19, 16 of which occurred after 1988. Recently, it has been observed that the incidence tended to increase. Of the 13 laboratory confirmed patients, 7 came from Saji Village and Chizu Town, in the Yazu district, a place whereby, a body of water known as the Sendai River partly passes through, and is located in the eastern region of Tottori Prefecture. The remaining 6 came from Nichinan Town in the Hino district, a locality whereby the Hino River partly passes through; in the western part of the same prefecture. Both are mountainous areas, where corniferous trees such as Japanese cedars and pines grow. These results indicate that the occurrence or prevalence of TD in Tottori Prefecture was restricted only to particular places. Seasonal occurrence was during April and May in Nichinan, while October and November in Yazu, particularly in Saji, with one exceptional case in Chizu in which TD occurred during spring. It is likely that the causative chigger mite is the Leptotrombidium pallidum (L. pallidum). The causative agent in Yazu was the Gilliam strain only of Orientia tsutsugamushi (O. tsutsugamushi), while in the latter, it was the Karp, Kato or some unknown strains with antigen(s) common to the Gilliam, Karp and Kato strains. The seasonal difference in the occurrence among the three places may be caused by the difference in temperature because the average autumn/spring temperature difference in the 2 districts was 2–3°C lower in Nichinan than in the Saji‐Chizu areas. As a result, the activity of larval chigger mites may be temporarily halted or stopped by the relatively lower temperature in Nichinan during autumn.
A Case of Classic Kaposi's Sarcoma with Multiple Organ Involvement
Authors: Jang Ho‐Sun , Cha Jung‐Hoon , Oh Chang‐Keum , Kwon Kyung‐Sool 
Published: April 2015

AbstractKaposi's sarcoma is a systemic, multifocal, angiomatous tumor which can be classified into four clinical variants. Among them, classic Kaposi's sarcoma is rare in Oriental people, and the involvement of internal organs in this variant is reported to be very rare. We present a case of classic Kaposi's sarcoma in a 67‐year‐old Korean male, who had multiple organ involvement in the skin, lymph node, and stomach. Lesions of Kaposi's sarcoma cleared after treatment with etoposide, but the skin lesions recurred after a three‐month symptom‐free period. He was treated with doxorubicin, bleomycin, and vincristine, and all the skin lesions were cleared.
Pedunculated Melanoma with Pulmonary and Bony Metastases
Authors: Kato Naoko , Kimura Kumiko , Sugawara Hiroshi , Aoyagi Satoru , Kondo Keishi , Yamashiro Katsushige 
Published: April 2015

AbstractWe report a patient with pedunculated melanoma. Rounded and epithelioid‐type melanoma cells had proliferated in the epidermis and massively into the deep dermis in the pedunculated nodule. At the base of the pedicle, lengtiginous‐type melanoma cells formed nests of various sizes in the epidermis extending ten or more rete ridges beyond the site of invasion. Thus, this case shows that a pedunculated melanoma is not necessarily a variant of nodular melanoma. Six years after the primary operation, late recurrence was detected in regional lymph nodes, and nine years after the initial operation, the patient was found to have three large metastatic nodules, up to 8.5 cm in longest diameter, in her lung and bone. Although she died six months after the metastasectomy, prompt surgical excision of the primary tumor and metastasectomy can provide longer survival.
Amblyomma testudinarium Tick Bite: One Case of Engorged Adult and a Case of Extraordinary Number of Larval Tick Infestation
Authors: Nakamura‐Uchiyama Fukumi , Komuro Yasuo , Yoshii Akira , Nawa Yukifumi 
Published: April 2015

AbstractThis paper reports two recent cases of tick bite due to Amblyomma testudinarium. The first case was an 86‐year‐old farmer infested with a fully engorged adult tick attached on his inguinal region. The second case was a 57‐year‐old male infested with an extraordinarily large number of larval ticks (>100 larvae). The ticks were identified as A. testudinarium based on morphological characteristics. To our knowledge, the latter case is the eleventh case of larval tick bites among all tick species and the fourth case with larval A. testudinarium in Japan.
Risk and Resilience Factors in the Mental Health and Well‐Being of Women with Intellectual Disability
Authors: Conder Jennifer Ann , Mirfin‐Veitch Brigit Frances , Gates Sue 
Published: April 2015

BackgroundWomen with intellectual disability are thought to be at increased risk of mental illness, yet little is known about resiliency factors supporting women's mental health. This article reports on such factors drawn from a study that aimed to address how women with intellectual disability experience their mental health and well‐being.Materials and MethodsUtilizing a broad qualitative approach, 25 New Zealand women, aged 21–65 years were interviewed about their life from childhood to the present, including, where relevant, their experience of mental illness. Data were analysed using a general inductive approach.ResultsResiliency factors aligned with the theme ‘keeping mentally well’, subthemes of which were as follows: the importance of relationships with family and friends; keeping busy; and autonomy and happiness. Challenges for resiliency could be seen in the theme ‘mental illness’ where subthemes of abuse, long‐term stress and medication were identified.ConclusionsMany of the women demonstrated remarkable resiliency, despite setbacks and exposure to risks, provided they were nested within a supportive context. Those women who experienced major mental illness shared evidence of both higher risk factors and less support available at crucial times.
Use of genomic recursions and algorithm for proven and young animals for single‐step genomic BLUP analyses – a simulation study
Authors: Fragomeni B.O. , Lourenco D.A.L. , Tsuruta S. , Masuda Y. , Aguilar I. , Misztal I. 
Published: April 2015

SummaryThe purpose of this study was to examine accuracy of genomic selection via single‐step genomic BLUP (ssGBLUP) when the direct inverse of the genomic relationship matrix (G) is replaced by an approximation of G−1 based on recursions for young genotyped animals conditioned on a subset of proven animals, termed algorithm for proven and young animals (APY). With the efficient implementation, this algorithm has a cubic cost with proven animals and linear with young animals. Ten duplicate data sets mimicking a dairy cattle population were simulated. In a first scenario, genomic information for 20k genotyped bulls, divided in 7k proven and 13k young bulls, was generated for each replicate. In a second scenario, 5k genotyped cows with phenotypes were included in the analysis as young animals. Accuracies (average for the 10 replicates) in regular EBV were 0.72 and 0.34 for proven and young animals, respectively. When genomic information was included, they increased to 0.75 and 0.50. No differences between genomic EBV (GEBV) obtained with the regular G−1 and the approximated G−1 via the recursive method were observed. In the second scenario, accuracies in GEBV (0.76, 0.51 and 0.59 for proven bulls, young males and young females, respectively) were also higher than those in EBV (0.72, 0.35 and 0.49). Again, no differences between GEBV with regular G−1 and with recursions were observed. With the recursive algorithm, the number of iterations to achieve convergence was reduced from 227 to 206 in the first scenario and from 232 to 209 in the second scenario. Cows can be treated as young animals in APY without reducing the accuracy. The proposed algorithm can be implemented to reduce computing costs and to overcome current limitations on the number of genotyped animals in the ssGBLUP method.
Does mothers’ postnatal depression influence the development of imitation?
Authors: Perra Oliver , Phillips Rebecca , Fyfield Rhiannon , Waters Cerith , Hay Dale F. 
Published: April 2015

BackgroundLinks between mothers’ postnatal depression (PND) and children's cognition have been identified in several samples, but the evidence is inconsistent. We hypothesized that PND may specifically interfere with infants’ imitation, an early learning ability that features in early mother–infant interaction and is linked to memory, causal understanding and joint attention.MethodsA randomly controlled experiment on imitation was embedded into a longitudinal study of a representative sample of firstborn British infants, whose mothers were assessed for depression using the SCAN interview during pregnancy and at 6 months postpartum. At a mean of 12.8 months, 253 infants were presented with two imitation tasks that varied in difficulty, in counterbalanced order.ResultsThe infants of mothers who experienced PND were significantly less likely than other infants in the sample to imitate the modelled actions, showing a 72% reduction in the likelihood of imitation. The association with PND was not explained by sociodemographic adversity, or a history of depression during pregnancy or prior to conception. Mothers’ references to infants’ internal states during mother–infant interaction at 6 months facilitated imitation at 12 months, but did not explain the link with PND.ConclusionsThe findings support the hypothesis that associations between PND and later cognitive outcomes may partly derive from effects of the mother's illness on infants’ early learning abilities. Support for infants’ learning should be considered as an age‐appropriate, child‐focused component of interventions designed to ameliorate the effects of PND.