bluuebunny/crossref_metadata_2025_split huggingface dataset:
Respiratory bellows‐gated late gadolinium enhancement of the left atrium
Authors: Peters Dana C. , Shaw Jaime L. , Knowles Benjamin R. , Moghari Mehdi Hedjazi , Manning Warren J. 
Published: November 2012

PurposeTo compare bellows‐gated late gadolinium enhancement (LGE) with standard navigator‐gated (NAV‐gated) LGE for left atrial (LA) imaging, to eliminate the inflow artifacts associated with NAV‐gating.Materials and MethodsEleven subjects, including six patients with atrial fibrillation (AF), were imaged with a 3D free‐breathing NAV‐gated and bellows‐gated LGE. Motion compensation was compared by blinded grading of image sharpness and motion ghosting (0 = worst, 2 = best). Inflow artifacts in the right inferior pulmonary vein (RIPV) and right superior PV (RSPV) were characterized on the same scale (0 = none, 2 = prominent). In patients, each PV was divided into four quadrants circumferentially in order to assess agreement about scar presence on both image sets.ResultsRespiratory compensation was not different (1.7 ± 0.5 vs. 1.6 ± 0.5, sharpness, 1.6 ± 0.5 vs. 1.6 ± 0.5, ghosting, P = NS) for bellows‐ and NAV‐gated images. For NAV‐gated LGE, inflow artifacts were more prominent in the RSPV than the RIPV (1.2 ± 0.8 vs. 0.7 ± 0.5, P = 0.046). Visually, inflow artifacts both obscured and mimicked the true scar. Disagreement on the presence of scar was found in 18% of the assessed quadrants, with 25% disagreement for RSPV quadrants (P = 0.01).ConclusionBellows‐gated LGE provides similar respiratory compensation as NAV‐gating, without inflow artifacts, leading to improved assessment of scar presence. J. Magn. Reson. Imaging 2013;38:1210–1214. © 2013 Wiley Periodicals, Inc.
Synthetic lipophilic antioxidant BO‐653 suppresses HCV replication
Authors: Yasui Fumihiko , Sudoh Masayuki , Arai Masaaki , Kohara Michinori 
Published: November 2012

AbstractThe influence of the intracellular redox state on the hepatitis C virus (HCV) life cycle is poorly understood. This study demonstrated the anti‐HCV activity of 2,3‐dihydro‐5‐hydroxy‐2,2‐dipentyl‐4,6‐di‐tert‐butylbenzofuran (BO‐653), a synthetic lipophilic antioxidant, and examined whether BO‐653's antioxidant activity is integral to its anti‐HCV activity. The anti‐HCV activity of BO‐653 was investigated in HuH‐7 cells bearing an HCV subgenomic replicon (FLR3‐1 cells) and in HuH‐7 cells infected persistently with HCV (RMT‐tri cells). BO‐653 inhibition of HCV replication was also compared with that of several hydrophilic and lipophilic antioxidants. BO‐653 suppressed HCV replication in FLR3‐1 and RMT‐tri cells in a concentration‐dependent manner. The lipophilic antioxidants had stronger anti‐HCV activities than the hydrophilic antioxidants, and BO‐653 displayed the strongest anti‐HCV activity of all the antioxidants examined. Therefore, the anti‐HCV activity of BO‐653 was examined in chimeric mice harboring human hepatocytes infected with HCV. The combination treatment of BO‐653 and polyethylene glycol‐conjugated interferon‐α (PEG‐IFN) decreased serum HCV RNA titer more than that seen with PEG‐IFN alone. These findings suggest that both the lipophilic property and the antioxidant activity of BO‐653 play an important role in the inhibition of HCV replication. J. Med. Virol. 85:241–249, 2013. © 2012 Wiley Periodicals, Inc.
Kinematic changes in patients with double arthrodesis of the hindfoot for realignment of planovalgus deformity
Authors: Schuh Reinhard , Salzberger Florian , Wanivenhaus Axel H. , Funovics Philipp T. , Windhager Reinhard , Trnka Hans‐Joerg 
Published: November 2012

AbstractDouble fusion (i.e., fusion of the subtalar and talonavicular joint) represents a modification of triple arthrodesis preserving integrity of the calcaneocuboidal joint. Our aims were (1) to evaluate dynamic plantar pressure distribution in patients undergoing double arthrodesis, (2) to obtain a comparison of kinematic changes to healthy feet, (3) to evaluate the influence of radiographic alignment, and (4) to assess functional outcome. Sixteen feet (14 patients) treated by double fusion due to fixed planovalgus deformity were included. Dynamic plantar pressure distribution was assessed using a capacitive pressure platform. Results were compared with a demographically matched control group. Clinical assessment included the American Orthopaedic Foot and Ankle Society (AOFAS) score and radiographic assessment included measurement of talometatarsal, calcaneal pitch, and talocalcaneal (TC) angle on lateral radiographs. Significant differences in plantar pressure distribution were found for maximum force of the hindfoot, midfoot, and big toe region: While the hindfoot and hallux represented decreased load in the double arthrodesis patients, load increased in the midfoot region compared with healthy controls. The lateral talus‐first metatarsal‐angle increased from −16.3° to −8.2°, and the TC angle decreased from 41.3° to 35.8° (p < 0.05). The pre‐ and post‐operative AOFAS score increased from 37 points (SD, 16.3) to 70 points (SD, 16.7). These results revealed that double arthrodesis represents a reliable method for correction of planovalgus deformity. Compared with healthy feet, force transmission of the midfoot is increased whereas push‐off force decreases. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 517–524, 2013
Fas ligand plays an important role for the production of pro‐inflammatory cytokines in intervertebral disc nucleus pulposus cells
Authors: Yamamoto Junya , Maeno Koichiro , Takada Toru , Kakutani Kenichiro , Yurube Takashi , Zhang Zhongying , Hirata Hiroaki , Kurakawa Takuto , Sakai Daisuke , Mochida Joji , Doita Minoru , Kurosaka Masahiro , Nishida Kotaro 
Published: November 2012

AbstractIt is suggested that pro‐inflammatory cytokines, which are produced by interaction of the intervertebral nucleus pulposus cells and macrophages, may be linked to the cause of pain of the intervertebral disc herniation. This study carries out the in vitro experiments to examine the mechanism, with the use of the co‐culture of an immortalized cell line of nucleus pulposus of the human intervertebral disc and the macrophage cell line. As a result, it is found that the production of pro‐inflammatory cytokines is significantly larger at the co‐culture group than at the independent culture group. Also, at the co‐culture group of macrophages and intervertebral nucleus pulposus cells with over‐expression of fas ligand (FasL), the production of pro‐inflammatory cytokines is found to be far larger. Furthermore, it is found that these pro‐inflammatory cytokines are produced mainly by the intervertebral nucleus pulposus cells with over‐expression of FasL, and that the expression of a disintegrin and metalloproteinase (ADAM) 10, which controls the expression of FasL and activates reverse signaling inside cells, also increases. From these findings, it is suggested that FasL and ADAM10 play an important role in the production of pro‐inflammatory cytokines coming from interaction of the intervertebral nucleus pulposus cells and macrophages. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 608–615, 2013
Investigation of variants within the COL27A1 and TNC genes and Achilles tendinopathy in two populations
Authors: Saunders Colleen J. , van der Merwe Lize , Posthumus Michael , Cook Jill , Handley Christopher J. , Collins Malcolm , September Alison V. 
Published: November 2012

AbstractThe TNC gene has previously been associated with Achilles tendinopathy (AT) in a South African population. The aims of this study were (i) to investigate the association of single nucleotide polymorphisms within the TNC gene, and the additional candidate gene, COL27A1, with AT in two populations, and (ii) to identify if there is a risk haplotype for AT in both populations. Three hundred and thirty nine healthy control participants (CON) and 179 participants clinically diagnosed with AT (TEN) from South Africa and Australia, were genotyped for variants: rs4143245, rs1249744, rs753085, rs946053 (COL27A1) and rs13321, rs2104772, rs1330363 (TNC). Haplotypes were inferred using the genotype data. The rs2104772 (p = 0.017) and rs1330363 (p = 0.020) variants within TNC showed a significant allele association with AT. The GCA haplotype (rs946053‐rs13321‐rs2104772) occurred significantly more frequently in TEN participants compared to CON (27% vs. 18%; p = 0.019). This study further implicates the genomic region containing the TNC and COL27A1 genes in influencing risk of AT, and maps the potential risk allele to a genetic interval flanked by rs946053 and rs2104772. This region may have functional effects on the transcription, structure and properties of tenascin‐C and the alpha‐1 chain of type XXVII collagen. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 632–637, 2013
In vivo bioluminescence imaging of magnetically targeted bone marrow‐derived mesenchymal stem cells in skeletal muscle injury model
Authors: Nakabayashi Akihiro , Kamei Naosuke , Sunagawa Toru , Suzuki Osami , Ohkawa Shingo , Kodama Akira , Kamei Goki , Ochi Mitsuo 
Published: November 2012

AbstractThe purpose of this study is to clarify the kinetics of transplanted mesenchymal stem cells (MSCs) in rat skeletal muscle injury model and the contribution of the magnetic cell delivery system to muscle injury repair. A magnetic field generator was used to apply an external magnetic force to the injury site of the tibia anterior muscle, and 1 × 106 MSCs labeled with ferucarbotran–protamine complexes, which were isolated from luciferase transgenic rats, were injected into the injury site. MSCs were injected with and without an external magnetic force (MSC M+ and MSC M− groups, respectively), and phosphate‐buffered saline was injected into injury sites as a control. In vivo bioluminescence imaging was performed immediately after the transplantation and, at 12, 24, and 72 h, and 1 and 4 weeks post‐transplantation. Also, muscle regeneration and function were histologically and electromechanically evaluated. In vivo bioluminescence imaging showed that the photon of the MSC M+ group was significantly higher than that of the MSC M− group throughout the observation period. In addition, muscle regeneration and function in the MSC M+ group was histologically and functionally better than that of the MSC M− group. The results of our study indicated that magnetic cell delivery system may be of use in directing the transplanted MSCs to the injury site to promote skeletal muscle regeneration. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 754–759, 2013
Photochemical Properties and Activity of Water‐Soluble Polymer/C60 Nanohybrids for Photodynamic Therapy
Authors: Hurtgen Marie , Debuigne Antoine , Hoebeke Maryse , Passirani Catherine , Lautram Nolwenn , Mouithys‐Mickalad Ange , Guelluy Pierre‐Henri , Jérôme Christine , Detrembleur Christophe 
Published: November 2012

AbstractWater‐soluble star‐like poly(vinyl alcohol)/C60 and poly{[poly(ethylene glycol) acrylate]‐co‐(vinyl acetate)}/C60 nanohybrids are prepared by grafting macroradicals onto C60 and are assessed as photosensitizers for photodynamic therapy. The photophysical and biological properties of both nanohybrids highlight key characteristics influencing their overall efficiency. The macromolecular structure (linear/graft) and nature (presence/absence of hydroxyl groups) of the polymeric arms respectively impact the photodynamic activity and the stealthiness of the nanohybrids. The advantages of both nanohybrids are encountered in a third one, poly[(N‐vinylpyrrolidone)‐co‐(vinyl acetate)]/C60, which has linear grafts without hydroxyl groups, and shows a better photodynamic activity. magnified image
Accessing New DPP‐Based Copolymers by Direct Heteroarylation Polymerization
Authors: Pouliot Jean‐Rémi , Mercier Lauren G. , Caron Samuel , Leclerc Mario 
Published: November 2012

AbstractA diketopyrrolopyrrole derivative was copolymerized with different electron‐withdrawing units [i.e., thieno[3,4‐c]pyrrole‐4,6‐dione (TPD), bis(thieno[3,4‐c]pyrrole‐4,6‐dione) (BTPD), and 3,4‐dicyanothiophene (DCT)] using direct heteroarylation polymerization (DHAP) methodology. Alternating copolymers with low‐lying frontier orbitals suitable for n‐type semiconducting behavior were obtained. Under optimized conditions, polymerization reactions were reproducible and high number‐average molecular weights (Mn) were achieved. Density functional theory (DFT) calculations indicated that the structures with the lowest conformational energy had planar backbones. Preliminary results showed that these new low‐bandgap materials exhibit good n‐type behavior.
Stable, Hydroxyl Functional Polycarbonates With Glycerol Side Chains Synthesized From CO2 and Isopropylidene(glyceryl glycidyl ether)
Authors: Geschwind Jeannette , Frey Holger 
Published: November 2012

AbstractA series of functional polycarbonates, poly((isopropylidene glyceryl glycidyl ether)‐co‐(glycidyl methyl ether) carbonate) (P((IGG‐co‐GME) C)) random copolymers with different fractions of 1,2‐isopropylidene glyceryl glycidyl ether (IGG) units, is synthesized. After acidic hydrolysis of the acetal protecting groups, a new type of functional polycarbonate prepared directly from CO2 and glycerol is obtained, namely poly((glyceryl glycerol)‐co‐(glycidyl methyl ether) carbonate) (P((GG‐co‐GME) C)). All hydroxyl functional samples exhibit monomodal molecular weight distributions with PDIs between 2.5 and 3.3 and Mn between 12 000 and 25 000 g mol−1. Thermal properties reflect the amorphous structure of the polymers. The materials are stable in bulk and solution.
Exome sequencing in a family with restless legs syndrome
Authors: Weissbach Anne , Siegesmund Katharina , Brüggemann Norbert , Schmidt Alexander , Kasten Meike , Pichler Irene , Muhle Hiltrud , Lohmann Ebba , Lohnau Thora , Schwinger Eberhard , Hagenah Johann , Stephani Ulrich , Pramstaller Peter P. , Klein Christine , Lohmann Katja 
Published: November 2012

AbstractBackground:Restless legs syndrome (RLS) has a high familial aggregation. To date, several loci and genetic risk factors have been identified, but no causative gene mutation has been found.Methods:We evaluated a German family with autosomal dominantly inherited RLS in 7 definitely and 2 possibly affected members by genome‐wide linkage analysis and exome sequencing.Results:We identified three novel missense and one splice site variant in the PCDHA3, WWC2, ATRN, and FAT2 genes that segregated with RLS in the family. All four exons of the PCDHA3 gene, the most plausible candidate, were sequenced in 64 unrelated RLS cases and 250 controls. This revealed three additional rare missense variants (frequency <1%) of unknown pathogenicity in 2 patients and 1 control.Conclusions:We present the first next‐generation sequencing study on RLS and suggest PCDHA3 as a candidate gene for RLS. © 2012 Movement Disorder Society
Modelling of wind shear downwind of mountain ridges at Hong Kong International Airport
Authors: Carruthers David , Ellis Andrew , Hunt Julian , Chan P. W. 
Published: November 2012

ABSTRACTA theoretical and computational study is presented of the wind flow over the mountain ridges to the south of Hong Kong International Airport given the upwind profiles of ‘mean’ velocity and temperature. A sensitivity study shows how large variations in wind speed, wind shear and wind direction occur on the approach path when the upwind flow from the southeast is stably stratified above the boundary layer with a significant inversion no more than a few hundred metres above the ridge (height about 450 m). The Froude number is close to unity. The effects of vertical wind shear across the inversion layer reduce the speed‐up, and directional wind shear changes the surface flow direction. The observed horizontal length scales along the approach are about equal to the projected widths of the predominant features of the ridges and valleys. For an extreme wind event there was found to be satisfactory agreement between the wind speed measured by a landing aircraft and the predictions of the fast quasi‐linear analytically based computer model FLOWSTAR. This suggests that near real time application of the model and near real time monitoring with remote and in situ instruments can be used to predict these extreme flow events and hence give warnings about them. Conclusions are drawn about how such predictive modelling could be developed.
Urge urinary incontinence and the brain factor
Authors: Morris Carolyn Louise 
Published: November 2012

AbstractAimsTo evaluate cognitive processing in elderly women with urge incontinence as compared to continent cohorts by measuring performance on neuropsychological tests of working memory, attention and inhibition. To measure speed of information processing, intensity of bladder filling sensation, and urine volume at a first desire (FDV) and strong desire to void (SDV), and level of attentional demands.MethodsTest measures included Operation and Reading Span, Wisconsin Card‐Sorting, Stroop Color Reading, Map Planning, and Maze Speed tests. A Likert scale measured bladder filling sensation intensity at FDV and SDV. An Attentional Demands Survey measured perceived attentional demands.ResultsWomen with urge incontinence had a mean severity index of 4.71 ± 2.7 with 84% demonstrating urge incontinence and 16% with mixed urge/stress incontinence. They experienced a FDV and a SDV to void at a lower bladder filling intensity with significantly smaller volumes of urine in the bladder compared to controls. Incontinent women also perceived significantly higher attentional demands but were not significantly different than controls on tests of executive function.ConclusionsWhile observations from neuroimaging provide evidence of differences between women with urge incontinence and controls in regional brain activity, efforts need to be made to decipher how these differences in metabolic activity relate to the fluid operations that create thoughts, decisions, and behavior. Neurourol. Urodynam. 32: 441–448, 2013. © 2012 Wiley Periodicals, Inc.
A bubble‐inspired algorithm for finite element mesh partitioning
Authors: Liu Peng , Wang Chao‐Fu 
Published: November 2012

SUMMARYThis paper presents a bubble‐inspired algorithm for partitioning finite element mesh into subdomains. Differing from previous diffusion BUBBLE and Center‐oriented Bubble methods, the newly proposed algorithm employs the physics of real bubbles, including nucleation, spherical growth, bubble–bubble collision, reaching critical state, and the final competing growth. The realization of foaming process of real bubbles in the algorithm enables us to create partitions with good shape without having to specify large number of artificial controls. The minimum edge cut is simply achieved by increasing the volume of each bubble in the most energy efficient way. Moreover, the order, in which an element is gathered into a bubble, delivers the minimum number of surface cells at every gathering step; thus, the optimal numbering of elements in each subdomain has naturally achieved. Because finite element solvers, such as multifrontal method, must loop over all elements in the local subdomain condensation phase and the global interface solution phase, these two features have a huge payback in terms of solver efficiency. Experiments have been conducted on various structured and unstructured meshes. The obtained results are consistently better than the classical kMetis library in terms of the edge cut, partition shape, and partition connectivity. Copyright © 2012 John Wiley & Sons, Ltd.
Emergency department visits in children with hemophilia
Authors: Özgönenel Bülent , Zia Ayesha , Callaghan Michael U. , Chitlur Meera , Rajpurkar Madhvi , Lusher Jeanne M. 
Published: November 2012

AbstractBackgroundThe pediatric emergency department (ED) management of bleeding and other complications of hemophilia constitutes an increasingly important component of hemophilia therapy. This retrospective study examined the overall ED use by children with hemophilia in a single center, with a particular aim to investigate visits related to injury or bleeding, and those related to blood stream infection in patients with a central venous catheter (CVC).MethodsElectronic medical records of patients with hemophilia presenting to Children's Hospital of Michigan ED were reviewed. Different categories of ED visits over a 5‐year period (January 2006–December 2010) were examined.ResultsThere were 536 ED visits from 84 male patients (median age 4 years, range 0–21) with hemophilia over the 5‐year period. The reasons for ED visits were: injury or bleeding (61.2%); suspected CVC‐related infection (11.8%); causes unrelated to hemophilia (19.2%); and routine clotting factor infusion (7.8%). Eighteen visits from six patients were secondary to injury or bleeding in a patient not yet diagnosed with hemophilia. An intracranial hemorrhage was detected in five visits. Overall, 5.4% of all visits represented distinct episodes of bloodstream infection.ConclusionThe pediatric ED is an indispensable component of the overall hemophilia care, because: (1) patients with potentially lethal problems such as ICH or CVC‐related infection may present to the ED for their initial management; (2) previously undiagnosed patients with hemophilia may also present to the ED for their first bleeding episodes, initiating the diagnostic investigations; (3) the ED provides after‐hours treatment service for many episodes of injury or bleeding, and also for clotting factor infusion. Pediatr Blood Cancer 2013; 60: 1188–1191. © 2012 Wiley Periodicals, Inc.
Practical recommendations for the management of children with Endemic Burkitt Lymphoma (BL) in a resource limited setting
Authors: Hesseling Peter , Israels Trijn , Harif Mhamed , Chantada Guillermo , Molyneux Elizabeth 
Published: November 2012

AbstractTreatment recommendations for endemic Burkitt lymphoma (BL) in settings with only minimum requirements for curative treatment (PODC setting 1) are described. The reported cure rate for endemic BL is usually <50%. Facilities within setting 1 differ. Three treatment schedules are proposed based on: (1) when accurate staging is not possible, (2) when staging is possible and for (3) relapses and poor responders to primary therapy. A literature review and personal experience were used to formulate the recommendations. Recorded 1‐year event free survival was 48% for treatment 1, 61% for treatment 2, and 35% for the rescue treatment. Pediatr Blood Cancer 2013; 60: 357–362. © 2012 Wiley Periodicals, Inc.