bluuebunny/crossref_metadata_2025_split huggingface dataset:
Information needs in parents of long‐term childhood cancer survivors
Authors: Vetsch Janine , Rueegg Corina S. , Gianinazzi Micòl E. , Bergsträsser Eva , von der Weid Nicolas X. , Michel Gisela ,   for the Swiss Paediatric Oncology Group (SPOG)
Published: February 2015

BackgroundParents’ knowledge about cancer, treatment, potential late effects and necessary follow‐up is important to reassure themselves and motivate their child to participate in regular follow‐up. We aimed to describe (i) parents’ perception of information received during and after treatment; (ii) parents’ current needs for information today, and to investigate; and (iii) associations between information needs and socio‐demographic and clinical characteristics.MethodsAs part of the Swiss Childhood Cancer Survivor Study, a follow‐up questionnaire was sent to parents of survivors, diagnosed < 16 years and after 1990, and aged 11–17 years at study. We assessed parents’ perception of information received and information needs, concerns about consequences of the cancer and socio‐demographic information. Information on clinical data was available from the Swiss Childhood Cancer Registry.ResultsOf 309 eligible parents, 189 responded (67%; mean time since diagnosis: 11.3 years, SD = 2.5). Parents perceived to have received verbal information (on illness: verbal 91%, written 40%; treatment: verbal 88%, written 46%; follow‐up: verbal 85% written 27%; late effects: verbal 75%, written 19%). Many parents reported current information needs, especially on late effects (71%). The preferred source was written general (28%) or verbal information (25%), less favored was online information (12%). Information needs were associated with migration background (P = 0.039), greater concerns about consequences of cancer (P = 0.024) and no information received (P = 0.035).ConclusionParents reported that they received mainly verbal information. However, they still needed further information especially about possible late effects. Individual long‐term follow‐up plans, including a treatment summary, should be provided to each survivor, preferably in written format. Pediatr Blood Cancer 2015;62:859–866. © 2015 Wiley Periodicals, Inc.
Pediatric patients who receive antibiotics for fever and neutropenia in less than 60 min have decreased intensive care needs
Authors: Salstrom Jennifer L. , Coughlin Rebecca L. , Pool Kathleen , Bojan Melissa , Mediavilla Camille , Schwent William , Rannie Michael , Law Dawn , Finnerty Michelle , Hilden Joanne 
Published: February 2015

BackgroundAntibiotic delivery to patients with fever and neutropenia (F&N) in <60 min is an increasingly important quality measure for oncology centers, but several published reports indicate that a time to antibiotic delivery (TTA) of <60 min is quite difficult to achieve. Here we report a quality improvement (QI) effort that sought to decrease TTA and assess associated clinical outcomes in pediatric patients with cancer and F&N.ProcedureWe used Lean‐Methodology and a Plan‐Do‐Study‐Act approach to direct QI efforts and prospectively tracked TTA measures and associated clinical outcomes (length of stay, duration of fever, use of imaging studies to search for occult infection, bacteremia, intensive care unit (ICU) consultation or admission, and mortality). We then performed statistical analysis to determine the impact of our QI interventions on total TTA, sub‐process times, and clinical outcomes.ResultsOur QI interventions significantly improved TTA such that we are now able to deliver antibiotics in <60 min nearly 100% of the time. All TTA sub‐process times also improved. Moreover, achieving TTA <60 min significantly reduced the need for ICU consultation or admission (P = 0.003) in this population.ConclusionHere we describe our QI effort along with a detailed assessment of several associated clinical outcomes. These data indicate that decreasing TTA to <60 min is achievable and associated with improved outcomes in pediatric patients with cancer and F&N. Pediatr Blood Cancer 2015;62:807–815. © 2015 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc.
Sorafenib treatment following hematopoietic stem cell transplant in pediatric FLT3/ITD acute myeloid leukemia
Authors: Tarlock Katherine , Chang Bill , Cooper Todd , Gross Thomas , Gupta Sumit , Neudorf Steven , Adlard Kathleen , Ho Phoenix A. , McGoldrick Suzanne , Watt Tanya , Templeman Tina , Sisler India , Garee Amy , Thomson Blythe , Woolfrey Ann , Estey Elihu , Meshinchi Soheil , Pollard Jessica A. 
Published: February 2015

BackgroundFLT3/ITD is associated with poor outcomes in adult and pediatric acute myeloid leukemia (AML). Allogeneic hematopoietic stem cell transplantation (HSCT) can improve cure rates, however relapse is still common. Recent studies demonstrate the activity of FLT3 inhibitors, including sorafenib, in targeting the underlying mutation.ProcedureWe conducted a retrospective study of 15 pediatric patients with FLT3/ITD+ AML treated with sorafenib within 18 months after receiving HSCT. Sorafenib was administered either as prophylaxis in patients considered at very high risk for relapse (n = 6) or at the time of disease recurrence (n = 9).ResultsSorafenib was initiated at a median of 100 days post HSCT. Overall, 11/15 (73%) of patients experienced medically significant toxicities. Among patients who experienced toxicity, 6/11 (55%) received treatment at doses above what was later determined to be the maximum tolerated dose of sorafenib for pediatric leukemia. Importantly, sorafenib did not appear to exacerbate graft versus host disease. Our findings suggest that sorafenib may be of particular efficacy in patients with minimal residual disease (MRD); all patients who received sorafenib for MRD immediately prior to transplant or with emergence post‐HSCT are alive and remain in complete remission at a median of 48 months post HSCT.ConclusionsOur case series suggests that sorafenib administration is feasible and tolerable in pediatric FLT3/ITD+ AML patients early post HSCT. Ongoing prospective controlled studies are needed to further define the dosing of sorafenib in the post‐HSCT period and to determine the optimal context for this treatment approach. Pediatr Blood Cancer 2015;62:1048–1054. © 2015 Wiley Periodicals, Inc.
Prevalence of post‐thrombotic syndrome after cardiac catheterization
Authors: Luceri Michael J. , Tala Joana A. , Weismann Constance G. , Silva Cicero T. , Faustino E. Vincent S. 
Published: February 2015

BackgroundAs the survival of children with cardiac disease increases, chronic complications of deep venous thrombosis from cardiac catheterization, particularly post‐thrombotic syndrome, may be important to monitor for and treat, if needed. We aimed to determine the prevalence of this syndrome in children who underwent cardiac catheterization.ProcedureWe conducted a cross‐sectional study of children <18 years old at least 1 year from first catheterization through the femoral vein. We used the Manco‐Johnson instrument, the only tool validated in children, to diagnose post‐thrombotic syndrome. We defined the syndrome as a score ≥1. It was considered physically and functionally significant if the score was ≥1 in both physical and functional domains of the instrument. We also conducted ultrasonography to assess for thrombosis and valvular insufficiency.ResultsWe enrolled 62 children with a median age of 4 months during catheterization and a median of 5.4 years since catheterization. A total of 40 children had post‐thrombotic syndrome (prevalence: 64.5%; 95% confidence interval: 51.3–76.3%), the majority of which were mild. Presence of cyanotic congenital heart disease, total number of catheterizations, use of antithrombotic agents at any time after the first catheterization, age at first catheterization, or time since first catheterization was not associated with the syndrome. A total of seven children (prevalence: 11.3%; 95% confidence interval: 3.2–19.4%) had physically and functionally significant syndrome. None of the children had abnormalities on ultrasonography at the time of enrollment.ConclusionsPost‐thrombotic syndrome is a common complication after cardiac catheterization. Manifestations are usually mild and unlikely to require treatment. Pediatr Blood Cancer 2015;62:1222–1227. © 2015 Wiley Periodicals, Inc.
Influence of image‐defined risk factors on the outcome of patients with localised neuroblastoma. A report from the LNESG1 study of the European International Society of Paediatric Oncology Neuroblastoma Group
Authors: Monclair Tom , Mosseri Véronique , Cecchetto Giovanni , De Bernardi Bruno , Michon Jean , Holmes Keith 
Published: February 2015

BackgroundThe European multicenter study LNESG1 was designed to evaluate the safety and efficacy of surgical treatment alone in patients with localised neuroblastoma. In a retrospective, observational study we examined the impact of image‐defined risk factors (IDRF) on operative complications and survival (EFS and OS).Procedure534 patients with localised, non‐MYCN amplified neuroblastoma were recruited between 1995 and 1999. Group 1 consisted of 291 patients without IDRF (Stage L1 in the International Neuroblastoma Risk Group (INRG) staging system), all treated with primary surgery. Group 2: 118 patients with IDRF (INRG Stage L2), also treated with primary surgery. Group 3: 125 patients in whom primary surgery was not attempted, 106 receiving neo‐adjuvant chemotherapy.ResultsIn L1 patients (Group 1) 5‐year EFS was 92% and OS 98%. In L2 patients (Group 2 and 3) EFS was 79% and OS 89%. The differences in both EFS and OS were significant. EFS and OS in Group 2 (86% and 95%) were significantly better than 73% and 83% in Group 3. In INSS stage 1, 2 and 3, EFS were respectively 94%, 81% and 76%. Except between stage 2 and 3 the differences were significant. OS were respectively 99%, 93% and 83%, all significantly different. The 17% operative complication rate in L2 patients was significantly higher than 5% in L1 patients.ConclusionsIn localised neuroblastoma, IDRF at diagnosis are associated with worse survival rates and higher rates of operative complications. The impact of IDRF should become an integrated part of therapy planning. Pediatr Blood Cancer 2015;62:1536–1542. © 2015 Wiley Periodicals, Inc.
Surface relief gratings inscription in linear and crosslinked azo modified epoxy‐isocyanate polymers
Authors: Sáiz Luciana M. , Ainchil Paula , Zucchi Ileana A. , Oyanguren Patricia A. , Galante María J. 
Published: February 2015

ABSTRACTThis work analyses the SRG forming ability of a linear and a crosslinked polymer, both based on the same azo chromophore (Disperse Red 19, DR19) and diisocyanate (4,4'‐metilen‐bis(cyclohexyl isocyanate), DI) with similar glass transition temperature values. The effect of the experimental and geometrical parameters (such as beams polarization direction and interference pattern spacing) on the surface modulation process was examined as well. The absence of photodegradation or bleaching was corroborated by comparing Raman spectra inside and outside the SRG zone. Being a very important subject matter, the influence of crosslinking on the inscription rates and thermal stability of SRGs was investigated. Crosslinked films with an interesting modulation and good grating stability, even at high temperatures (160 °C), were obtained. Gratings shape was retained, and significant diffraction was still observed even well above the Tg of the bulk sample. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015, 53, 587–594
Methanol‐induced change of the mechanism of the temperature‐ and pressure‐induced collapse of N‐Substituted acrylamide copolymers
Authors: Hofmann Christian H. , Grobelny Sebastian , Panek Paweł T. , Heinen Laura K. M. , Wiegand Ann‐Kristin , Plamper Felix A. , Jacob Christoph R. , Winter Roland , Richtering Walter 
Published: February 2015

ABSTRACTThe solvation of two differently composed linear statistical copolymers from N,N‐diethyl acrylamide (DEAm) and N‐isopropyl acrylamide is studied by Fourier‐transform infrared spectroscopy. The solvent is changed from pure water to mixtures with methanol to investigate the cononsolvency effect. Furthermore, the influence of temperature and pressure is studied. The IR results are interpreted by sub‐band fitting of the amide I' band and quantum–chemical calculations. There are significant differences between the two copolymers that cannot be explained by a weighted superposition of the homopolymer spectra. An excess of DEAm units leads to a high number of nonsolvated side chains already in pure water. This high number is reached for equimolar copolymers only when methanol is added. The mechanism of the temperature‐ or pressure‐induced phase transition changes upon methanol addition for both copolymers. Generally, the phenomena are deduced to cooperativity at equimolar composition that is perturbed by methanol. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2015, 53, 532–544
Crystal structure of YwpF from Staphylococcus aureus reveals its architecture comprised of a β‐barrel core domain resembling type VI secretion system proteins and a two‐helix pair
Authors: Lee Sang Jae , Lee Kyu‐Yeon , Lee Ki‐Young , Kim Dong‐Gyun , Kim Soon‐Jong , Lee Bong‐Jin 
Published: February 2015

ABSTRACTThe ywpF gene (SAV2097) of the Staphylococcus aureus strain Mu50 encodes the YwpF protein, which may play a role in antibiotic resistance. Here, we report the first crystal structure of the YwpF superfamily from S. aureus at 2.5‐Å resolution. The YwpF structure consists of two regions: an N‐terminal core β‐barrel domain that shows structural similarity to type VI secretion system (T6SS) proteins (e.g., Hcp1, Hcp3, and EvpC) and a C‐terminal two‐helix pair. Although the monomer structure of S. aureus YwpF resembles those of T6SS proteins, the dimer/tetramer model of S. aureus YwpF is distinct from the functionally important hexameric ring of T6SS proteins. We therefore suggest that the S. aureus YwpF may have a different function compared to T6SS proteins. Proteins 2015; 83:781–788. © 2015 Wiley Periodicals, Inc.
Optimum distribution of additional reinforcement to reduce differential column shortening
Authors: Kim Han‐Soo 
Published: February 2015

SummaryDifferential column shortening should be reduced to mitigate the adverse effects caused by such shortening in a tall building. The axial stiffness of columns with greater shortening than adjacent columns should be increased to reduce the differential column shortening. The axial stiffness of the columns can be effectively increased by utilizing additional reinforcement for them. The optimum distributions of this additional reinforcement to reduce the differential column shortening in a tall building are determined. An optimization problem is formulated to minimize the total amount of reinforcement. Three analysis models, namely a fixed‐section, fixed‐stress and general model, are presented as numerical examples. The contour plots for a two‐variable problem of the three analysis models are presented. The generalized reduced gradient method is applied to obtain the optimum solutions of multi‐variable problems. The differential column shortenings after optimization confirm that the optimization program developed in this study can yield the optimum distributions of additional reinforcement. Copyright © 2015 John Wiley & Sons, Ltd.
Profile of (n‐9) and (n‐7) Isomers of Monounsaturated Fatty Acids of Radish (Raphanus sativus L.) seeds
Authors: Kaymak Haluk Caglar 
Published: February 2015

AbstractThe present study was undertaken to determine the profile of the (n‐9) and (n‐7) isomers for C18:1, C20:1 and C22:1 fatty acids in radish seeds as well as their isomers. Radish (Raphanus sativus L. cvs. ‘Antep, Beyaz, Cherry Belle and Iri Kırmızı’) seeds were produced in 2003–2005 from different sowing dates (SD). The n‐7 isomers of C18:1, C20:1 and C22:1 ranged from 0.7 to 1.3, 0.1 to 0.3 and 0.4 to 1.1 %, respectively. The average values of C18:1(n‐7) was highest (1 %) amongst the three acids. The ratios of (n‐7)/(n‐9) ranged from 4.5 % (‘Cherry Belle’, SD‐I) to 8.3 % (‘Antep’, SD‐III), 0.8 % (‘Iri Kırmızı’, SD‐II) to 3 % (‘Iri Kırmızı’, SD‐I) and 1.6 % (‘Cherry Belle’, SD‐I) to 3.7 % (‘Iri Kırmızı’, SD‐I) for C18:1, C20:1 and C22:1. Erucic acid was the principal fatty acid with concentrations of nearly 34–39 % in ‘Antep’, 32–34 % in ‘Cherry Belle’, 30–33 % in ‘Beyaz’ and 21–22 % in ‘Irı Kırmızı’. The oleic acid content was higher in SD‐I and SD‐II than SD‐III in all cultivars. Correlation studies revealed that palmitoleic acid (C16:1) had a significant relationship between most of the fatty acids of the (n‐7)/(n‐9) family. The results indicated that palmitoleic acid is important in the synthesis of long‐chain fatty acids and that the data for the (n‐7)/(n‐9) ratios for C22:1 could be used as biochemical markers to determine the similarities or differences between radish cultivars.
Determination of Fatty Acid Profiles and Esterase Activities in the Gills and Gonads of Vimba vimba (L., 1758)
Authors: Görgün Salih , Zengin Gökhan 
Published: February 2015

AbstractThe main purpose of this study was to evaluate the gills and gonads of Vimba vimba in terms of fatty acid composition, esterase activity, and esterase band patterns by native‐PAGE method. In this context, C16:0 and C18:1n‐9 were the most abundant fatty acids in the TLs, NLs, and the PLs fractions of both tissues. EPA (C20:5n‐3) and DHA (C22:6n‐3) levels were higher in the gills than in the gonads. MUFAs were the main fatty acid groups in the TLs, NLs, and PLs of both tissues. Gills had higher n‐3/n‐6 ratios when compared with the gonads, with the exception of the PLs. TLs of the gonads had the highest AI and TI values. A concentration of 1 mM Na‐taurocholate increased the esterase activity of the gonads. Other chemicals having inhibition and surface active effects resulted in decreases in the esterase activities at concentrations of 1, 5, and 10 mM. In total, nine esterase bands were determined in both tissues. Four bands were shared by both the gills and gonads of V.vimba. These shared bands could be responsible for the similar esterase activities in both tissues. Gills and gonads of V. vimba have substantial amounts of fatty acids and esterase isozymes. More detailed studies are required to understand their industrial and nutritional uses.
A reliable and valid method for manual demarcation of hippocampal head, body, and tail
Authors: Daugherty Ana M. , Yu Qijing , Flinn Robert , Ofen Noa 
Published: February 2015

AbstractThere is a growing interest in characterizing functional specialization along the long axis of the hippocampus in humans. Variability in volumetry along the long axis of the hippocampus may be of functional relevance in human development, and in a number of clinical populations. However, there is a lack of consistent definitions for measurements of regional volumetry along the hippocampal long axis. Moreover, there is lack of consistent reliability standards of these measures. Here we describe a protocol for manual demarcation of hippocampal head, body, and tail. The definitions emphasize anatomical landmarks that agree with the extant literature and are visible in children and adults alike. Using this protocol we achieved high reliability of all volumetric measures. We further demonstrate that the protocol can be applied to T2‐weighted images optimized for high‐resolution scanning of the hippocampus, as well as a more standard T1‐weighted image sequence. Third, the protocol is sensitive to detect individual differences in subregion volumes in normally developing children (N = 81; ages 8–25 years). This protocol may be of use for researchers studying the hippocampus across the lifespan and in diverse clinical populations.
High plasma neopterin levels in Chinese children with autism spectrum disorders
Authors: Zhao Hong‐xiang , Yin Sha‐sha , Fan Jin‐gang 
Published: February 2015

AbstractBackgroundNeopterin, a pteridine mainly synthesized by activated macrophages, is a marker of inflammation, immune system activation and an active participant in Autism spectrum disorders (ASD). The aim of this study was to assess the clinical significance of plasma neopterin levels in ASD.MethodsEighty patients diagnosed with ASD and 80 sex and age matched typically developing children were assessed for plasma levels of neopterin at admission. Plasma neopterin levels were measured using a human ELISA kit and severity of ASD were evaluated with the Childhood Autism Rating Scale (CARS) score.ResultsWe found that the mean plasma neopterin level was significantly (P < 0.0001) higher in children with ASD as compared to controls. Plasma neopterin increased with increasing severity of ASD as defined by the CARS score. Based on the ROC curve, the optimal cutoff value of plasma neopterin level as an indicator for auxiliary diagnosis of ASD was projected to be 8.5 nmol/L, which yielded a sensitivity of 84.2% and a specificity of 80.1%, with the area under the curve at 0.876 (95% CI, 0.825–0.928). Elevated neopterin (≥8.5 nmol/L) was an independent diagnosis indicator of ASD with an adjusted OR of 12.11 (95% CI: 5.48–28.11; P < 0.0001).ConclusionsThese results indicated that autistic children had higher plasma levels of neopterin, and elevated plasma neopterin levels may be associated with severity of ASD among Chinese children.
Subjective memory impairment in older adults predicts future dementia independent of baseline memory performance: Evidence from the Betula prospective cohort study
Authors: Rönnlund Michael , Sundström Anna , Adolfsson Rolf , Nilsson Lars‐Göran 
Published: February 2015

AbstractIntroductionThe objective was to examine whether subjective memory impairment (SMI) predicts all‐cause dementia or Alzheimer's disease (AD) in a population‐based study with long‐term follow‐up (median = 10 years).MethodsA total of 2043 initially dementia‐free participants (≥ 60 years) made three memory ratings (“compared with others”, “compared with five years ago”, and “complaints from family/friends”) at baseline. During follow‐up, 372 participants developed dementia (208 with AD).ResultsCox regression revealed that subjective memory impairment ratings predicted all‐cause dementia in models adjusting for age and sex (hazard ratio or HR from 2.04 to 3.94), with even higher values for AD (HR from 2.29 to 5.74). The result persisted in models including other covariates, including baseline episodic memory performance, and in analyses restricted to participants with long time to dementia diagnosis (≥ 5 years).DiscussionThe findings underscore the usefulness of subjective memory assessment in combination with other factors in identifying individuals at risk for developing dementia.
Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasis
Authors: Christianson Dawn R. , Dobroff Andrey S. , Proneth Bettina , Zurita Amado J. , Salameh Ahmad , Dondossola Eleonora , Makino Jun , Bologa Cristian G. , Smith Tracey L. , Yao Virginia J. , Calderone Tiffany L. , O'Connell David J. , Oprea Tudor I. , Kataoka Kazunori , Cahill Dolores J. , Gershenwald Jeffrey E. , Sidman Richard L. , Arap Wadih , Pasqualini Renata 
Published: February 2015

Significance
Formation of metastasis is the most deadly step in melanoma progression and primarily occurs through the lymphatic vasculature. Unfortunately, little is known regarding the underlying molecular mechanisms that enable interactions between melanoma cells and lymphatic vessels. In this study, we developed an unbiased approach using combinatorial peptide libraries displayed on phage coat proteins to identify cell–cell interacting proteins at the lymphatic vessel–tumor cell interface. Successful application of this approach led to the identification of cell surface PPP2R1A on both melanoma and lymphatic cell surfaces, and more importantly, PPP2R1A facilitates tumor cell–lymphatic endothelial cell interactions during melanoma cell metastasis.