bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pyridyl‐Decorated Self‐Folding Heptaamide Cavitands as Ligands in the Rhodium‐Catalyzed Hydrogenation of Norbornadiene
Authors: Korom Saša , Ballester Pablo 
Published: June 2014

AbstractThe different binding geometries exhibited in solution by the RhI cationic complexes of three regioisomeric self‐folding heptaamide cavitands, each decorated with one pyridyl group at the upper rim, are taken into account to explain the diverse distributions of products obtained when these complexes are employed as catalysts for the hydrogenation of norbornadiene.
Signal Processing and Stochastic Filtering for EIS Based PHM of Fuel Cell Systems
Authors: Gašperin M. , Boškoski P. , Debenjak A. , Petrovčič J. 
Published: June 2014

AbstractThis paper presents an alternative computational method for on‐line estimation and tracking of the impedance of PEM fuel cell systems. The method is developed in order to provide the information to diagnostics and health management system. Proper water management remains the main issue influencing the reliability and durability of PEM fuel cell technology. While literature reviews reveal the thorough understanding of the underlying processes and extensive experimental work, the existing implementations rely on expensive hardware or time consuming computational methods. In this scope, we will show how the characteristic values of the fuel cell impedance, required by the diagnostic system, can be computed by robust and computationally efficient algorithms, which are suitable for implementation in embedded systems. The methods under consideration include continuous‐time wavelet transform (CWT) and extended Kalman filter (EKF). The CWT is a time‐frequency technique, which is suitable for tracking transient signal components. The EKF is a stochastic signal processing method, which provides confidence measures for the estimates. The paper shows, that both methods provide accurate estimates for diagnostics of FCS and can perform on‐line tracking of these features. The performance of the algorithms is validated on experimental data from a commercial fuel cell stack.
Direct Hybridization Fuel Cell – Ultracapacitors
Authors: Morin B. , Van Laethem D. , Turpin C. , Rallières O. , Astier S. , Jaafar A. , Verdu O. , Plantevin M. , Chaudron V. 
Published: June 2014

AbstractIt is now well recognized that highly dynamic power demands accelerate the ageing of a fuel cell. A solution is to hybridize it with an electrochemical storage device (ultracapacitors, Li‐ion battery...). Whatever the technique implemented to manage energy, the hybridization principle forces the storage device to take in charge the rapid power changes to protect the fuel cell. Several electrical architectures are possible to interconnect the fuel cell and the storage device: indirect hybridization via power converters, or direct hybridization without power converters. The work here focuses on direct hybridization between a fuel cell and ultracapacitors.Classically, this kind of connection concerns the hybridization of a fuel cell stack with an ultracapacitors' pack. The authors here investigate another rather original option by implementing this hybridization at the scale of each cell of a fuel cell stack. In this approach, each elementary ultracapacitor can be connected either to one cell or to two cells.Before applying the concept to a real fuel cell stack (the final objective), the authors studied the concepts with single cells. This paper is going to present the intensive experimental works achieved to apprehend the principles. Static and dynamics properties of such hybridization are analyzed and modeled.
Effects of sodium acetate buffer on chitosan sponge properties andin vivodegradation in a rat intramuscular model
Authors: Parker Ashley Cox , Smith James Keaton , Reves Benjamin , Jennings Jessica Amber , Bumgardner Joel D. , Haggard Warren O. 
Published: June 2014

AbstractChitosan sponges were developed for adjunctive local antibiotic delivery to reduce bacteria in wounds. There is a need to increase sponge degradation for rapid clearance from the wound site during initial wound care. This work examined the effect of using 0.25Msodium acetate buffers, at pH 4.6 or 5.6, to fabricate sponges with an amorphous chitosan polymer structure. Sponges were evaluated for their crystallinity, thermal, spectroscopic, and morphological properties, in addition toin vitrodegradation, and cytocompatibility analysis using normal human dermal fibroblasts.In vivodegradation and biocompatibility were also examined after 4 and 10 days in rat intramuscular tissues. Both buffered chitosan sponge variations exhibited decreases in crystallinity and thermal decomposition temperatures, and increases in surface roughness, which resulted in over 40% increases in degradation over 10 daysin vitrocompared to the neutral sponges. There were no significant differences between sponges duringin vivodegradation over 10 days with respect to histomorphometric analysis of the recovered sponges. These results demonstrated that the acetate buffer did change characteristic chitosan sponge material properties, and increasing thein vivosponge degradation rate will require balancing material characteristics and processing. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 387–396, 2015.
Generalized Balanced Tournament Packings and Optimal Equitable Symbol Weight Codes for Power Line Communications
Authors: Chee Y. M. , Kiah H. M. , Ling A. C. H. , Wang C. 
Published: June 2014

AbstractGeneralized balanced tournament packings (GBTPs) extend the concept of generalized balanced tournament designs introduced by Lamken and Vanstone (1989). In this paper, we establish the connection between GBTPs and a class of codes called equitable symbol weight codes (ESWCs). The latter were recently demonstrated to optimize the performance against narrowband noise in a general coded modulation scheme for power line communications. By constructing classes of GBTPs, we establish infinite families of optimal ESWCs with code lengths greater than alphabet size and whose narrowband noise error‐correcting capability to code length ratios do not diminish to zero as the length grows.
Shoot‐through current reduction scheme for low power LTPS TFT programmable shift register
Authors: Song Eunji , Nam Hyoungsik 
Published: June 2014

AbstractThis paper proposes a programmable pulse width shift register where an output pulse width is adjusted only by changing a start pulse width without any additional signals and reconfiguration for the pre‐charging scheme of high resolution and high frame rate active‐matrix flat‐panel displays. In addition, the overall power consumption of a proposed circuitry is dramatically reduced by alleviating the shoot‐through current of an interval inverter, compared with the previous shift registers with the programmable or fixed output pulse width. The proposed shift register is verified by the simulation program with integrated circuit emphasis (SPICE) simulation at low temperature poly‐Si thin film transistor process for 50 stages. The proposed shift register lessens the power consumption by 34% and 54% for the output pulse widths of two and 10 line times, respectively, compared with those of the previous shift register structures.
Enhanced Fluorescence Quenching of 2‐Thiohydantoin‐Containing Conjugated Polymers: Applications for Ion Sensing
Authors: Zeng Weifeng , Yong Xue , Yang Xiaodong , Yan Yichen , Lu Xinwei , Qu Jinqing , Liu Ruiyuan 
Published: June 2014

A novel poly(phenylene ethynylene) containing 2‐thiohydantoin [poly(1)] is synthesized. The addition of F− quenches the fluorescence, while the fluorescence of the solution only changes slightly upon addition of other anions, indicating the sensing ability of poly(1) toward F−. The addition of Ag+ quenches the fluorescence of the polymer, whereas the addition of other metal ions results in only slight changes to the fluorescence. Compared with its small‐molecule counterpart, the Stern–Volmer quenching constants of poly(1) toward F− and Ag+ are 165 and 105 times greater, respectively. This result indicates the amplified quenching effect of poly(1).
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Novel ANO5 homozygous microdeletion causing myalgia and unprovoked rhabdomyolysis in an Arabic man
Authors: Lahoria Rajat , Winder Thomas L. , Lui Jie , Al‐Owain Mohammed A. , Milone Margherita 
Published: June 2014

ABSTRACTIntroduction: Recessive mutations in the anoctamin‐5 gene (ANO5) cause a spectrum of clinical phenotypes, including limb‐girdle muscular dystrophy (LGMD 2L), distal myopathy, and asymptomatic hyperCKemia. Methods: In this report we describe our clinical, electrophysiological, pathological, and molecular findings in a subject with anoctaminopathy‐5. Results: A 49‐year‐old Arabic man from a consanguineous family presented with a 5‐year history of myalgias, hyperCKemia and an episode of unprovoked rhabdomyolysis. Muscle biopsy showed mild myopathic changes and interstitial amyloid deposition. ANO5 analysis detected a novel homozygous deletion of approximately 11.9 kb encompassing exons 13–17, predicted to be pathogenic. Conclusions: Anoctaminopathy‐5 can manifest with a phenotype reminiscent of metabolic myopathy and should be considered as a potential cause of myalgia and myoglobinuria. Amyloid deposition in the muscle biopsy is helpful for the diagnosis. A novel homozygous ANO5 deletion was identified, suggesting that screening for common mutations may have low yield in non‐European subjects. Muscle Nerve 50: 610–613, 2014
Patient perception of pain versus observed pain behavior during a standardized electrodiagnostic test
Authors: Verson Josh , Haig Andrew J. , Sandella Danielle , Yamakawa Karen S.J. , London Zachary , Tomkins‐Lane Christy 
Published: June 2014

ABSTRACTIntroduction: Clinicians often assume that observations of pain behavior are adequate for assessment of patient pain perception during procedures. This has not been tested during a standardized electrodiagnostic experience. Methods: During a prospective trial including extensive, standardized electrodiagnostic testing on persons with lumbar stenosis, vascular claudication, and asymptomatic volunteers, the subjects and an observer rated levels of pain. Results: In 60 subjects, observers significantly under‐rated pain (Visual Analog Scale 3.17 ± 2.23 vs. 4.38 ± 2.01, t = −4.577, df = 59, P < 0.001). Perceived pain during testing related to bodily pain as measured by the visual analog, McGill, Pain Disability, and Quebec scales, but not age, duration of symptoms, Tampa kinesiphobia, Center for Epidemiological Studies Depression scale, or SF‐36 health quality of life. Conclusions: Persons with worse pain syndromes may perceive more pain during testing than others. Clinicians and researchers should understand that patients may have more pain than they recognize. Muscle Nerve 51: 185–191, 2015
Enzyme structure captures four cysteines aligned for disulfide relay
Authors: Gat Yair , Vardi‐Kilshtain Alexandra , Grossman Iris , Major Dan Thomas , Fass Deborah 
Published: June 2014

AbstractThioredoxin superfamily proteins introduce disulfide bonds into substrates, catalyze the removal of disulfides, and operate in electron relays. These functions rely on one or more dithiol/disulfide exchange reactions. The flavoenzyme quiescin sulfhydryl oxidase (QSOX), a catalyst of disulfide bond formation with an interdomain electron transfer step in its catalytic cycle, provides a unique opportunity for exploring the structural environment of enzymatic dithiol/disulfide exchange. Wild‐type Rattus norvegicus QSOX1 (RnQSOX1) was crystallized in a conformation that juxtaposes the two redox‐active di‐cysteine motifs in the enzyme, presenting the entire electron‐transfer pathway and proton‐transfer participants in their native configurations. As such a state cannot generally be enriched and stabilized for analysis, RnQSOX1 gives unprecedented insight into the functional group environments of the four cysteines involved in dithiol/disulfide exchange and provides the framework for analysis of the energetics of electron transfer in the presence of the bound flavin adenine dinucleotide cofactor. Hybrid quantum mechanics/molecular mechanics (QM/MM) free energy simulations based on the X‐ray crystal structure suggest that formation of the interdomain disulfide intermediate is highly favorable and secures the flexible enzyme in a state from which further electron transfer via the flavin can occur.
Self‐assembly of azide containing dipeptides
Authors: Yuran Sivan , Razvag Yair , Das Priyadip , Reches Meital 
Published: June 2014

AbstractFunctional structures and materials are formed spontaneously in nature through the process of self‐assembly. Mimicking this process in vitro will lead to the formation of new substances that would impact many areas including energy production and storage, biomaterials and implants, and drug delivery. The considerable structural diversity of peptides makes them appealing building blocks for self‐assembly in vitro. This paper describes the self‐assembly of three aromatic dipeptides containing an azide moiety: H‐Phe(4‐azido)‐Phe(4‐azido)‐OH, H‐Phe(4‐azido)‐Phe‐OH, and H‐Phe‐Phe(4‐azido)‐OH. The peptide H‐Phe(4‐azido)‐Phe(4‐azido)‐OH self‐assembled into porous spherical structures, whereas the peptides H‐Phe(4‐azido)‐Phe‐OH and H‐Phe‐Phe(4‐azido)‐OH did not form any ordered structures under the examined experimental conditions. The azido group of the peptide can serve as a photo cross‐linking agent upon irradiation with UV light. To examine the effect of this group and its activity on the self‐assembled structures, we irradiated the assemblies in solution for different time periods. Using electron microscopy, we determined that the porous spherical assemblies formed by the peptide H‐Phe(4‐azido)‐Phe(4‐azido)‐OH underwent a structural change upon irradiation. In addition, using FT‐IR, we detected the chemical change of the peptide azido group. Moreover, using indentation experiments with atomic force microscopy, we showed that the Young's modulus of the spherical assemblies increased after 20 min of irradiation with UV light. Overall, irradiating the solution of the peptide assemblies containing the azido group resulted in a change both in the morphology and mechanical properties of the peptide‐based structures. These ordered assemblies or their peptide monomer building blocks can potentially be incorporated into other peptide assemblies to generate stiffer and more stable materials. Copyright © 2014 European Peptide Society and John Wiley & Sons, Ltd.
A Distribution‐freeCUSUMChart for Monitoring Variability of AutocorrelatedProcesses
Authors: Kim Seong‐Hee 
Published: June 2014

AbstractWe present a distribution‐free tabular cumulative sum chart for monitoring the variability of an autocorrelated process. A quantity known as the asymptotic variance parameter is employed as a measure of the variability, and a distribution‐free tabular cumulative sum chart is applied to variance estimates calculated from batches of nonoverlapping samples. The proposed chart is applicable to a stationary process with a general marginal distribution and a general autocorrelation structure. It also determines control limits analytically without trial‐and‐error simulations. The performance of the proposed chart is tested on stationary processes with both normal and nonnormal marginals with various autocorrelation structures. Copyright © 2014 John Wiley & Sons, Ltd.
The significance of GBA for Parkinson's disease
Authors: Brockmann Kathrin , Berg Daniela 
Published: June 2014

AbstractFrom the first descriptions of Parkinson's disease (PD) and Gaucher's disease (GD) in the nineteenth century, it took more than 100 years to discover the link between the GBA gene and Parkinsonism. The observation that mutations in the GBA gene represent the most common genetic risk factor for PD so far only came into focus because of astute clinical observation of Gaucher patients and their families. In this review, we (i) outline how GBA was identified as a genetic risk factor for Parkinsonism, (ii) present clinical characteristics of GBA‐associated Parkinsonism, (iii) discuss possible mechanisms of the underlying pathogenesis in GBA‐associated Parkinsonism, and (iv) provide an outlook on potentially new areas of research and treatment that arise from this important discovery.
Sodium Alkyl Ether Sulfonates (SAES): Dual Anionic‐Nonionic Behavior in Synthetic Brine Having High Salinity and Hardness
Authors: Al‐Faraji Said , Al‐Maamari Rashid S. , Aoudia Mohamed 
Published: June 2014

AbstractDue to the presence of non‐sulfonated residual alkyl ether (AE), sodium alkyl ether sulfonate (SAES) may exhibit clear point‐cloud point solubilization behavior in brine. Accordingly, the effect of temperature on the compatibility of iC17EOxS (x = 7 and 10), nC17EO10S, along with their analogous nonionic surfactants iC17EOxH (x = 7 and 10) and nC17EO10, in addition to iC9EO14 in brine has been investigated. Depending on their molecular structures, these surfactants exhibited concentration‐dependent clear point and cloud point solubilization behavior. The cloud point was associated with the AE component whereas the clear point was attributed to the sulfonated one. Interestingly, an increase in the cloud point of the nonionic component with respect to the corresponding nonionic AE (100 % active) was observed. Adding iC9EO14 (100 % active) to iC17EO7S (xan = 0.0–0.362) resulted in a significant decrease in the clear point of iC17EO7S from above 100 °C to below 22 °C with a concomitant increase in iC17EO7/iC9EO14 mixture cloud point from 68 °C. (xan = 0) to 72 °C (xan = 0.325). This relatively modest increase by 4 °C was attributed to the interrelationship of different competitive mechanisms, namely an increase in mixed micelle charge with increasing xan, the dehydration of OE groups via ion (SO3−)‐dipole (O → CH2) interactions, and possible shielding of SO3− groups by iC9EO14 nearby extended EO groups. To the best of our knowledge, this is the first instance where dual anionic‐nonionic solubilization behavior of SAES in brine characterized by high salinity and hardness is being reported.
Superlubricity on the nanometer scale
Authors: Meyer Ernst , Gnecco Enrico 
Published: June 2014

Abstract
The transition from atomic stick-slip to continuous sliding has been observed in a number of ways. If extended contacts are moved in different directions, so-called structural lubricity is observed when the two surface lattices are non-matching. Alternatively, a “superlubric” state of motion can be achieved if the normal force is reduced below a certain threshold, the temperature is increased, or the contact is actuated mechanically. These processes have been partially demonstrated using atomic force microscopy, and they can be theoretically understood by proper modifications of the Prandtl-Tomlinson model.
AURKA regulates JAK2–STAT3 activity in human gastric and esophageal cancers
Authors: Katsha Ahmed , Arras Janet , Soutto Mohammed , Belkhiri Abbes , El-Rifai Wael 
Published: June 2014

Aurora kinase A is a frequently amplified and overexpressed gene in upper gastrointestinal adenocarcinomas (UGCs). Using in vitro cell models of UGCs, we investigated whether AURKA can regulate Signal Transducer and Activator of Transcription 3 (STAT3). Our data indicate that overexpression of AURKA in FLO‐1 and AGS cells increase STAT3 phosphorylation at the Tyr705 site, whereas AURKA genetic depletion by siRNA results in decreased phosphorylation levels of STAT3 in FLO‐1 and MKN45 cells. Immunofluorescence analysis showed that AURKA overexpression enhanced STAT3 nuclear translocation while AURKA genetic knockdown reduced the nuclear translocation of STAT3 in AGS and FLO‐1 cells, respectively. Using a luciferase reporter assay, we demonstrated that AURKA expression induces transcriptional activity of STAT3. Pharmacological inhibition of AURKA by MLN8237 reduced STAT3 phosphorylation along with down‐regulation of STAT3 pro‐survival targets, BCL2 and MCL1. Moreover, by using clonogenic cells survival assay, we showed that MLN8237 single dose treatment reduced the ability of FLO‐1 and AGS cells to form colonies. Additional experiments utilizing cell models of overexpression and knockdown of AURKA indicated that STAT3 upstream non‐receptor tyrosine kinase Janus kinase 2 (JAK2) is mediating the effect of AURKA on STAT3. The inhibition of JAK2 using JAK2‐specific inhibitor AZD1480 or siRNA knockdown, in presence of AURKA overexpression, abrogated the AURKA‐mediated STAT3 activation. These results confirm that the AURKA‐JAK2 axis is the main mechanism by which AURKA regulates STAT3 activity. In conclusion, we report, for the first time, that AURKA promotes STAT3 activity through regulating the expression and phosphorylation levels of JAK2. This highlights the importance of targeting AURKA as a therapeutic approach to treat gastric and esophageal cancers.
Differential effects of proteins and carbohydrates on postprandial blood pressure-related responses
Authors: Teunissen-Beekman Karianna F. M. , Dopheide Janneke , Geleijnse Johanna M. , Bakker Stephan J. L. , Brink Elizabeth J. , de Leeuw Peter W. , Serroyen Jan , van Baak Marleen A. 
Published: June 2014

Diet composition may affect blood pressure (BP), but the mechanisms are unclear. The aim of the present study was to compare postprandial BP-related responses to the ingestion of pea protein, milk protein and egg-white protein. In addition, postprandial BP-related responses to the ingestion of maltodextrin were compared with those to the ingestion of sucrose and a protein mix. We hypothesised that lower postprandial total peripheral resistance (TPR) and BP levels would be accompanied by higher plasma concentrations of nitric oxide, insulin, glucagon-like peptide 1 (GLP-1) and glucagon. On separate occasions, six meals were tested in a randomised order in forty-eight overweight or obese adults with untreated elevated BP. Postprandial responses of TPR, BP and plasma concentrations of insulin, glucagon, GLP-1 and nitrite, nitroso compounds (RXNO) and S-nitrosothiols (NOx) were measured for 4 h. No differences were observed in TPR responses. Postprandial BP levels were higher after the ingestion of the egg-white-protein meal than after that of meals containing the other two proteins (P≤ 0·01). The ingestion of the pea-protein meal induced the highest NOxresponse (P≤ 0·006). Insulin and glucagon concentrations were lowest after the ingestion of the egg-white-protein meal (P≤ 0·009). Postprandial BP levels were lower after the ingestion of the maltodextrin meal than after that of the protein mix and sucrose meals (P≤ 0·004), while postprandial insulin concentrations were higher after the ingestion of the maltodextrin meal than after that of the sucrose and protein mix meals after 1–2 h (P≤ 0·0001). Postprandial NOx, GLP-1 and glucagon concentrations were lower after the ingestion of the maltodextrin meal than after that of the protein mix meal (P≤ 0·008). In conclusion, different protein and carbohydrate sources induce different postprandial BP-related responses, which may be important for BP management. Lower postprandial BP levels are not necessarily accompanied by higher NOx, insulin, glucagon or GLP-1 responses.