bluuebunny/crossref_metadata_2025_split huggingface dataset:
An accurate performance analysis of an FFR scheme in the downlink of cellular systems under large-shadowing effect
Authors: Pijcke Benoit , Gazalet Marc , Zwingelstein-Colin Marie , Coudoux François-Xavier 
Published: February 2013

Abstract
We address the problem of analyzing the performances of interference-limited cellular networks in large-scale shadowing environments. Focusing on the fractional frequency reuse (FFR) framework, we examine how to optimally assign mobile users in a cell either to the full frequency reuse part or to the orthogonal part of the FFR band. Instead of using traditional Monte Carlo simulations, which do not provide sufficiently accurate results under important shadowing, we propose a fast and accurate numerical method. We consider a fast-fading environment and we use the ergodic capacity as the performance measure. Applying a distributed power control and scheduling strategy, we examine both cases where access points have knowledge of partial- or full-channel state information (CSI); for the latter, we also propose an approximated waterfilling strategy. The interest of our method lies in the fact that it allows for a fast and accurate analysis of the performances of FFR. In addition, it takes into account a broad range of shadowing environments.
James Joyce’S Dublin and Lars Saabye Christensen’s Oslo. Geocritical Readings
Authors: Rus Andra-Lucia 
Published: February 2013

Abstract
This paper analyzes the literary representations of Dublin and Oslo in the novels of James Joyce, respectively Lars Saabye Christensen. The methodology derives from concepts introduced by Bertrand Westphal in his books on geocriticism, with a special emphasis on the performative nature of literature in relation to space production.
Grace Signal Filtering as a Means of Determining Equivalent Water Thickness in Poland
Authors: Biryło Monika , Nastula Jolanta 
Published: February 2013

AbstractIn the paper an Equivalent Water Thickness (EWT) determination as a way of observing gravity variations is described. Since raw data acquired directly from Gravity Recovery and Climate Experiment - GRACE satellites is unsuitable for analysis due to stripes occurrence, a filtering algorithm must be used. In this paper, authors are testing two isotropic (Gauss, CNES/GRGS) filters and two anisotropic filters (Wiener- -Kolomogorov, ANS). Correlation, amplitude ratio, and modification were determined as well as maps were generated.
Isolation of Yersinia Enterocolitica O:9 From Cows Positive in Serological Examination of Bovine Brucellosis
Authors: Weiner Marcin , Szulowski Krzysztof , Iwaniak Wojciech 
Published: February 2013

Abstract
The paper presents the results of bacteriological and molecular investigations on the presence of Y. enterocolitica O:9 in the head, mammary and genital lymph nodes, spleen, liver, and uterus samples originating from 58 cows slaughtered due to the positive results of serological examinations for brucellosis. All samples were cultured for Brucella and Y. enterocolitica and examined in multiplex PCR assay (mPCR), in order to identify the universal 16S rRNA Brucella sp. marker and amplify the perosamine synthetase (per) gene, specific for Y. enterocolitica O:9 only. Out of 58 examined animals, in 23 cases the presence of Y.
enterocolitica was demonstrated. Typical Yersinia-suspected colonies were seen after 24-48 h incubation on Cefsulodin-Irgasan- Novobiocin (CIN) Yersinia selective solid medium. The mPCR analysis confirmed the presence of predicted amplicon of 312 bp, typical for Y. enterocolitica O:9 in 20 out of 58 lymph node samples tested and similarly, as in bacteriological examination, other samples were negative. The presence of the 16S rRNA gene of Brucella, generating the amplicon of 905 bp, was not observed in any of the samples tested.
Skandinaviska Filmer i Världen
Authors: Marklund Anders 
Published: February 2013

ABSTRACT
This article analyses three recent and very successful Scandinavian films - Niels Arden Oplev’s Män som hatar kvinnor/The
Girl with the Dragon Tatoo (Sweden), Susanne Bier’s Hævnen/In a
Better World (Denmark) and Sara Johnsen’s Upperdog (Norway) - in order to understand how the relationship between the national and the international is articulated. Focus is on the scenes taking place abroad and on the functions that these scenes fill within the films’ overall story and thematic concerns. One conclusion is that scenes set abroad allow the films to divert attention away from otherwise harsh representations of national communities. A brief concluding discussion suggests that such a use of the scenes may facilitate the films’ transnational distribution.
Integration of the tagging mechanism in the collaborative e-learning system
Authors: Lesovskis Andrejs , Kotovs Vladimirs , Novickis Leonids 
Published: February 2013

Abstract -
The tagging mechanism is a technique that can be used to implement the personalized collaboration in the e-Learning systems, thereby increasing the efficiency of such a system. Semantic Web technologies can be used to enhance tags with machine-readable annotations to improve the accuracy of tag-based recommendation services.
The novelty of the proposed approach is the combined use of the Semantic Web technologies and the reuse-oriented model in the development of the e-Learning environment.
Environmental Toxicant Exposure and Depressive Symptoms
Authors: Guo Jianhui , Garshick Eric , Si Feifei , Tang Ziqi , Lian Xinyao , Wang Yaqi , Li Jing , Koutrakis Petros 
Published: July 2024

ImportanceRecognizing associations between exposure to common environmental toxicants and mental disorders such as depression is crucial for guiding targeted mechanism research and the initiation of disease prevention efforts.ObjectivesTo comprehensively screen and assess the associations between potential environmental toxicants and depressive symptoms and to assess whether systemic inflammation serves as a mediator.Design, Setting, and ParticipantsA total of 3427 participants from the 2013-2014 and 2015-2016 waves of the National Health and Nutrition Examination and Survey who had information on blood or urine concentrations of environmental toxicants and depression scores assessed by the 9-item Patient Health Questionnaire (PHQ-9) were included. Statistical analysis was performed from July 1, 2023, to January 31, 2024.ExposuresSixty-two toxicants in 10 categories included acrylamide, arsenic, ethylene oxide, formaldehyde, iodine, metals, nicotine metabolites, polycyclic aromatic hydrocarbons, volatile organic compound (VOC) metabolites; and perchlorate, nitrate, and thiocyanate.Main Outcomes and MeasuresAn exposome-wide association study and the deletion-substitution-addition algorithm were used to assess associations with depression scores (PHQ-9 ≥5) adjusted for other important covariates. A mediation analysis framework was used to evaluate the mediating role of systemic inflammation assessed by the peripheral white blood cell count.ResultsAmong the 3427 adults included, 1735 (50.6%) were women, 2683 (78.3%) were younger than 65 years, and 744 (21.7%) were 65 years or older, with 839 (24.5%) having depressive symptoms. In terms of race and ethnicity, 570 participants (16.6%) were Mexican American, 679 (19.8%) were non-Hispanic Black, and 1314 (38.3%) were non-Hispanic White. We identified associations between 27 chemical compounds or metals in 6 of 10 categories of environmental toxicants and the prevalence of depressive symptoms, including the VOC metabolites N-acetyl-S-(2-hydroxy-3-butenyl)-l-cysteine (odds ratio [OR], 1.74 [95% CI, 1.38, 2.18]) and total nicotine equivalent-2 (OR, 1.42 [95% CI, 1.26-1.59]). Men and younger individuals appear more vulnerable to environmental toxicants than women and older individuals. Peripheral white blood cell count mediated 5% to 19% of the associations.Conclusions and RelevanceIn this representative cross-sectional study of adults with environmental toxicant exposures, 6 categories of environmental toxicants were associated with depressive symptoms with mediation by systemic inflammation. This research provides insight into selecting environmental targets for mechanistic research into the causes of depression and facilitating efforts to reduce environmental exposures.
0.01% Atropine Eye Drops in Children With Myopia and Intermittent Exotropia
Authors: Wang Zijin , Li Tianxi , Zuo Xiaoxia , Zhang Tong , Liu Lei , Zhou Chenyu , Leng Zhenhua , Chen Xuejuan , Wang Lingyan , Wang Xiaofeng , Liu Hu 
Published: July 2024

ImportanceExotropia and myopia are commonly coexistent. However, evidence is limited regarding atropine interventions for myopia control in children with myopia and intermittent exotropia (IXT).ObjectiveTo evaluate the efficacy and safety of 0.01% atropine eye drops on myopia progression, exotropia conditions, and binocular vision in individuals with myopia and IXT.Design, Setting, and ParticipantsThis placebo-controlled, double-masked, randomized clinical trial was conducted from December 2020 to September 2023. Children aged 6 to 12 years with basic-type IXT and myopia of −0.50 to −6.00 diopters (D) after cycloplegic refraction in both eyes were enrolled.InterventionParticipants were randomly assigned in a 2:1 ratio to 0.01% atropine or placebo eye drops administered in both eyes once at night for 12 months.Main Outcomes and MeasuresThe primary outcome was change in cycloplegic spherical equivalent from baseline at 1 year. Secondary outcomes included change in axial length (AL), accommodative amplitude (AA), exotropia conditions, and binocular vision at 1 year.ResultsAmong 323 screened participants, 300 children (mean [SD] age, 9.1 [1.6] years; 152 male [50.7%]) were included in this study. A total of 200 children (66.7%) were in the atropine group, and 100 (33.3%) were in the placebo group. At 1 year, the 0.01% atropine group had slower spherical equivalent progression (−0.51 D vs −0.75 D; difference = 0.24 D; 95% CI, 0.11-0.37 D; P &amp;lt; .001) and AL elongation (0.31 mm vs 0.42 mm; difference = −0.11 mm; 95% CI, −0.17 to −0.06 mm; P &amp;lt; .001) than the placebo group. The mean AA change was −3.06 D vs 0.12 D (difference = −3.18 D; 95% CI, −3.92 to −2.44 D; P &amp;lt; .001) in the atropine and placebo groups, respectively. The 0.01% atropine group had a decrease in near magnitude of exodeviation whereas the placebo group had an increase (−1.25 prism diopters [PD] vs 0.74 PD; difference = −1.99 PD; 95% CI, −3.79 to −0.19 PD; P = .03). In the atropine vs placebo group, respectively, the incidence of study drug-related photophobia was 6.0% (12 of 200 participants) vs 8.0% (8 of 100 participants; difference = −2.0%; 95% CI, −9.4% to 3.7%; P = .51) and for blurred near vision was 6.0% (12 of 200 participants) vs 7.0% (7 of 100 participants) (difference = −1.0%; 95% CI, −8.2% to 4.5%; P = .74).Conclusions and RelevanceThe findings of this randomized clinical trial support use of 0.01% atropine eye drops, although compromising AA to some extent, for slowing myopia progression without interfering with exotropia conditions or binocular vision in children with myopia and IXT.Trial RegistrationChinese Clinical Trial Registry Identifier: ChiCTR2000039827
Hearing Loss, Hearing Aids, and Functional Status
Authors: Assi Sahar , Twardzik Erica , Kucharska-Newton Anna M. , Windham B. Gwen , Reed Nicholas S. , Palta Priya , Martinez-Amezcua Pablo 
Published: July 2024

ImportanceHearing loss may contribute to poor functional status via cognitive impairment and social isolation. Hearing aids may play a protective role by attenuating these downstream outcomes. However, population-based evidence is lacking.ObjectiveTo examine the association of hearing loss and hearing aids with functional status.Design, Setting, and ParticipantsThis cross-sectional (2016-2017) and longitudinal (2016-2022) analysis of data from the Atherosclerosis Risk in Communities cohort study included older, community-dwelling adults with complete data. Data were analyzed from June to December 2023.ExposuresThe better-hearing ear’s pure tone average (BPTA) at speech frequencies (0.5-4 kHz) was modeled categorically (no [BPTA ≤25 dB], mild [26-40 dB], and moderate or greater hearing loss [&amp;gt;40 dB]). Hearing aid use was self-reported.Main Outcomes and MeasuresDifficulties in activities of daily living (ADLs; eg, dressing and eating), instrumental activities of daily living (IADLS; eg, household chores and meal preparation), and heavier tasks (eg, walking a quarter of a mile) were self-reported at visit 6. The ability to perform usual activities, walk a half mile, walk up and down stairs, and do heavy housework without help were collected in follow-up surveys. Linear and logistic regression models were used that were adjusted for sociodemographic and health covariates.ResultsAmong 3142 participants (mean [SD] age, 79.3 [4.6] years; 1828 women [58.2%]), 1013 (32.2%) had no hearing loss, 1220 (38.8%) had mild hearing loss, and 909 (29.0%) had moderate or greater hearing loss. Moderate or greater hearing loss was cross-sectionally associated with difficulty in 1 or more ADLs (odds ratio [OR], 1.27; 95% CI, 1.02-1.58), IADLs (OR, 1.34; 95% CI, 1.05-1.71), and heavier tasks (OR, 1.29; 95% CI, 1.04-1.62) compared with no hearing loss. Over time (mean [SD] follow-up, 1.9 [1.8] years), moderate or greater hearing loss was associated with a faster decline in the number of activities participants were able to do (β = −0.07 per year; 95% CI, −0.09 to −0.06) and greater odds of reporting inability to do 1 or more of the 4 activities (OR, 1.14; 95% CI, 1.05-1.24). Hearing aid users and nonusers did not differ.Conclusions and RelevanceThe results of this study suggest that moderate or greater hearing loss was associated with functional difficulties and may contribute to a faster decline in function longitudinally independent of sociodemographic and health covariates. Hearing aids did not change the association among those with hearing loss.
Annulative Coupling of β‐Ketosulfoxonium Ylides and β‐Ketothioamides: Access to Thiazolines and Thiazolidin‐4‐Ones
Authors: Kumar Saini Rahul , Kumar Pandey Satyendra 
Published: July 2024

AbstractA catalyst‐ and additive‐free one‐step protocol for synthesizing thiazolines and thiazolidin‐4‐ones, utilizing the annulative coupling between β‐ketosulfoxonium ylides and β‐ketothioamides has been described. The dual functionalization of β‐ketosulfoxonium ylides through S‐alkylation and intramolecular N‐cyclization leads to the generation of both C−S and C−N bonds. The developed synthetic methods facilitate the synthesis of diverse functionalized thiazolines and thiazolidin‐4‐one derivatives, validated through large‐scale reactions.
Identification of a Hippocampus‐to‐Zona Incerta Projection involved in Motor Learning
Authors: Zhang Zhuo‐Hang , Wang Bo , Peng Yan , Xu Ya‐Wei , Li Chang‐Hong , Ning Ya‐Lei , Zhao Yan , Shan Fa‐Bo , Zhang Bo , Yang Nan , Zhang Jing , Chen Xing , Xiong Ren‐Ping , Zhou Yuan‐Guo , Li Ping 
Published: July 2024

AbstractMotor learning (ML), which plays a fundamental role in growth and physical rehabilitation, involves different stages of learning and memory processes through different brain regions. However, the neural mechanisms that underlie ML are not sufficiently understood. Here, a previously unreported neuronal projection from the dorsal hippocampus (dHPC) to the zona incerta (ZI) involved in the regulation of ML behaviors is identified. Using recombinant adeno‐associated virus, the projections to the ZI are surprisingly identified as originating from the dorsal dentate gyrus (DG) and CA1 subregions of the dHPC. Furthermore, projection‐specific chemogenetic and optogenetic manipulation reveals that the projections from the dorsal CA1 to the ZI play key roles in the acquisition and consolidation of ML behaviors, whereas the projections from the dorsal DG to the ZI mediate the retrieval/retention of ML behaviors. The results reveal new projections from the dorsal DG and dorsal CA1 to the ZI involved in the regulation of ML and provide insight into the stages over which this regulation occurs.
Complex Hydride‐Based Gel Polymer Electrolytes for Rechargeable Ca‐Metal Batteries
Authors: Shinohara Takara , Kisu Kazuaki , Dorai Arunkumar , Zushida Kenji , Yabu Hiroshi , Takagi Shigeyuki , Orimo Shin‐ichi 
Published: July 2024

AbstractRechargeable Ca batteries offer the advantages of high energy density, low cost, and earth‐abundant constituents, presenting a viable alternative to lithium‐ion batteries. However, using polymer electrolytes in practical Ca batteries is not often reported, despite its potential to prevent leakage and preserve battery flexibility. Herein, a Ca(BH4)2‐based gel‐polymer electrolyte (GPE) is prepared from Ca(BH4)2 and poly(tetrahydrofuran) (pTHF) and tested its performance in Ca batteries. The electrolyte demonstrates excellent stability against Ca‐metal anodes and high ionic conductivity. The results of infrared spectroscopy and 1H and 11B NMR indicate that the terminal ─OH groups of pTHF reacted with BH4− anions to form B─H─(pTHF)3 moieties, achieving cross‐linking and solidification. Cyclic voltammetry measurements indicate the occurrence of reversible Ca plating/stripping. To improve the performance at high current densities, the GPE is supplemented with LiBH4 to achieve a lower overpotential in the Ca plating/stripping process. An all‐solid‐state Ca‐metal battery with a dual‐cation (Ca2+ and Li+) GPE, a Ca‐metal anode, and a Li4Ti5O12 cathode sustained >200 cycles, confirming their feasibility. The results pave the way for further developing lithium salt‐free Ca batteries by developing electrolyte salts with high oxidation stability and optimal electrochemical properties.
Engineering of a DNA/γPNA Hybrid Nanoreporter for ctDNA Mutation Detection via γPNA Urinalysis
Authors: Xiang Zhichu , Lu Jianhua , Ming Yang , Guo Weisheng , Chen Xiaoyuan , Sun Weijian 
Published: July 2024

AbstractDetection of circulating tumor DNA (ctDNA) mutations, which are molecular biomarkers present in bodily fluids of cancer patients, can be applied for tumor diagnosis and prognosis monitoring. However, current profiling of ctDNA mutations relies primarily on polymerase chain reaction (PCR) and DNA sequencing and these techniques require preanalytical processing of blood samples, which are time‐consuming, expensive, and tedious procedures that increase the risk of sample contamination. To overcome these limitations, here the engineering of a DNA/γPNA (gamma peptide nucleic acid) hybrid nanoreporter is disclosed for ctDNA biosensing via in situ profiling and recording of tumor‐specific DNA mutations. The low tolerance of γPNA to single mismatch in base pairing with DNA allows highly selective recognition and recording of ctDNA mutations in peripheral blood. Owing to their remarkable biostability, the detached γPNA strands triggered by mutant ctDNA will be enriched in kidneys and cleared into urine for urinalysis. It is demonstrated that the nanoreporter has high specificity for ctDNA mutation in peripheral blood, and urinalysis of cleared γPNA can provide valuable information for tumor progression and prognosis evaluation. This work demonstrates the potential of the nanoreporter for urinary monitoring of tumor and patient prognosis through in situ biosensing of ctDNA mutations.
UBX‐390: A Novel Androgen Receptor Degrader for Therapeutic Intervention in Prostate Cancer
Authors: Lee Soohyun , Kim Hwa‐Ryeon , Woo Yaejin , Kim Jiyoung , Kim Han Wool , Park Ji Youn , Suh Beomseon , Choi Yuri , Ahn Jungmin , Ryu Je Ho , Roe Jae‐Seok , Song Jaewhan , Lee Song Hee 
Published: July 2024

AbstractThe androgen receptor (AR) is an attractive target for treating prostate cancer, considering its role in the development and progression of localized and metastatic prostate cancer. The high global mortality burden of prostate cancer, despite medical treatments such as androgen deprivation or AR antagonist therapy, highlights the need to explore alternative strategies. One strategy involves the use of heterobifunctional degraders, also known as proteolysis‐targeting chimeras, which are novel small‐molecule therapeutics that inhibit amplified or mutated targets. Here, the study reports a novel cereblon‐based AR degrader, UBX‐390, and demonstrates its superior activity over established AR degraders, such as ARV‐110 or ARCC‐4, in prostate cancer cells under short‐ and long‐term treatment conditions. UBX‐390 suppresses chromatin binding and gene expression of AR and demonstrates substantial efficacy in the degradation of AR mutants in patients with treatment‐resistant prostate cancer. UBX‐390 is presented as an optimized AR degrader with remarkable potential for treating castration‐resistant prostate cancer.
Thermally Oxidized Memristor and 1T1R Integration for Selector Function and Low‐Power Memory
Authors: Pan Zhidong , Zhang Jielian , Liu Xueting , Zhao Lei , Ma Jingyi , Luo Chunlai , Sun Yiming , Dan Zhiying , Gao Wei , Lu Xubing , Li Jingbo , Huo Nengjie 
Published: July 2024

AbstractResistive switching memories have garnered significant attention due to their high‐density integration and rapid in‐memory computing beyond von Neumann's architecture. However, significant challenges are posed in practical applications with respect to their manufacturing process complexity, a leakage current of high resistance state (HRS), and the sneak‐path current problem that limits their scalability. Here, a mild‐temperature thermal oxidation technique for the fabrication of low‐power and ultra‐steep memristor based on Ag/TiOx/SnOx/SnSe2/Au architecture is developed. Benefiting from a self‐assembled oxidation layer and the formation/rupture of oxygen vacancy conductive filaments, the device exhibits an exceptional threshold switching behavior with high switch ratio exceeding 106, low threshold voltage of ≈1 V, long‐term retention of >104 s, an ultra‐small subthreshold swing of 2.5 mV decade−1 and high air‐stability surpassing 4 months. By decreasing temperature, the device undergoes a transition from unipolar volatile to bipolar nonvolatile characteristics, elucidating the role of oxygen vacancies migration on the resistive switching process. Further, the 1T1R structure is established between a memristor and a 2H‐MoTe2 transistor by the van der Waals (vdW) stacking approach, achieving the functionality of selector and multi‐value memory with lower power consumption. This work provides a mild‐thermal oxidation technology for the low‐cost production of high‐performance memristors toward future in‐memory computing applications.
A Se Nanoparticle/MgFe‐LDH Composite Nanosheet as a Multifunctional Platform for Osteosarcoma Eradication, Antibacterial and Bone Reconstruction
Authors: Bian Yixin , Zhao Kexin , Hu Tingting , Tan Chaoliang , Liang Ruizheng , Weng Xisheng 
Published: July 2024

AbstractDespite advances in treating osteosarcoma, postoperative tumor recurrence, periprosthetic infection, and critical bone defects remain critical concerns. Herein, the growth of selenium nanoparticles (SeNPs) onto MgFe‐LDH nanosheets (LDH) is reported to develop a multifunctional nanocomposite (LDH/Se) and further modification of the nanocomposite on a bioactive glass scaffold (BGS) to obtain a versatile platform (BGS@LDH/Se) for comprehensive postoperative osteosarcoma management. The uniform dispersion of negatively charged SeNPs on the LDH surface restrains toxicity‐inducing aggregation and inactivation, thus enhancing superoxide dismutase (SOD) activation and superoxide anion radical (·O2−)‐H2O2 conversion. Meanwhile, Fe3+ within the LDH nanosheets can be reduced to Fe2+ by depleting glutathione (GSH) in the tumor microenvironments (TME), which can catalyze H2O2 into highly toxic reactive oxygen species. More importantly, incorporating SeNPs significantly promotes the anti‐bacterial and osteogenic properties of BGS@LDH/Se. Thus, the developed BGS@LDH/Se platform can simultaneously inhibit tumor recurrence and periprosthetic infection as well as promote bone regeneration, thus holding great potential for postoperative “one‐stop‐shop” management of patients who need osteosarcoma resection and scaffold implantation.