bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Current Eligibility Criteria for Bariatric Surgery
Authors: Sjöholm Kajsa , Anveden Åsa , Peltonen Markku , Jacobson Peter , Romeo Stefano , Svensson Per-Arne , Sjöström Lars , Carlsson Lena M.S. 
Published: January 2013

OBJECTIVE
Patients with a BMI &lt;35 kg/m2 and patients with a BMI between 35 and 40 kg/m2 without comorbidities are noneligible by current eligibility criteria for bariatric surgery. We used Swedish obese subjects (SOS) to explore long-term outcomes in noneligible versus eligible patients.

RESEARCH DESIGN AND METHODS
The SOS study involved 2,010 obese patients who underwent bariatric surgery (68% vertical-banded gastroplasty, 19% banding, and 13% gastric bypass) and 2,037 contemporaneously matched obese controls receiving usual care. At inclusion, the participant age was 37–60 years and BMI was ≥34 kg/m2 in men and ≥38 kg/m2 in women. The effect of surgery was assessed in patients that do (n = 3,814) and do not (n = 233) meet current eligibility criteria. The date of analysis was 1 January 2012. The follow-up time was up to 20 years, with a median of 10 years.

RESULTS
Cardiovascular risk factors were significantly improved both in noneligible and eligible individuals after 10 years of follow-up. Surgery reduced the diabetes incidence in both the noneligible (adjusted hazard ratio 0.33 [95% CI 0.13–0.82], P = 0.017) and eligible (0.27 [0.22–0.33], P &lt; 0.001) groups. We could not detect a difference in the effect of surgery between the groups (adjusted interaction P value = 0.713).

CONCLUSIONS
Bariatric surgery drastically reduced the incidence of type 2 diabetes both in noneligible and eligible patients and improved cardiovascular risk factors in both groups. Our results show that strict BMI cutoffs are of limited use for bariatric surgery prioritization if the aim is to prevent diabetes and improve cardiovascular risk factors.
GLP-1 Action and Glucose Tolerance in Subjects With Remission of Type 2 Diabetes After Gastric Bypass Surgery
Authors: Jiménez Amanda , Casamitjana Roser , Viaplana-Masclans Judith , Lacy Antonio , Vidal Josep 
Published: January 2013

OBJECTIVE
Glucagon like peptide-1 (GLP-1) has been suggested as a major factor for the improved glucose tolerance ensuing after Roux-en-Y gastric bypass (RYGBP) surgery. We examined the effect of blocking endogenous GLP-1 action on glucose tolerance in subjects with sustained remission of type 2 diabetes mellitus (T2DM) present before RYGBP.

RESEARCH DESIGN AND METHODS
Blood glucose, insulin, C-peptide, glucagon, GLP-1, and glucose-dependent insulinotropic peptide levels were measured after a meal challenge with either exendin-(9–39) (a GLP-1r antagonist) or saline infusion in eight subjects with sustained remission of T2DM after RYGBP and seven healthy controls.

RESULTS
Infusion of exendin-(9–39) resulted in marginal deterioration of the 2-h plasma glucose after meal intake in RYGBP subjects [saline 78.4 ± 15.1 mg/dL compared with exendin-(9–39) 116.5 ± 22.3 mg/dL; P &lt; 0.001]. Furthermore, glucose response to meal intake was similarly enlarged in the two study groups [percent change in the area under the curve of glucose exendin-(9–39) infusion versus saline infusion: controls 10.84 ± 8.8% versus RYGBP 9.94 ± 8.4%; P = 0.884]. In the RYGBP group, the blockade of the enlarged GLP-1 response to meal intake resulted in reduced insulin (P = 0.001) and C-peptide (P &lt; 0.001), but no change in glucagon (P = 0.258) responses.

CONCLUSIONS
The limited deterioration of glucose tolerance on blockade of GLP-1 action in our study suggests the resolution of T2DM after RYGBP may be explained by mechanisms beyond enhancement of GLP-1 action.
Four-Year Analysis of Cardiovascular Disease Risk Factors, Depression Symptoms, and Antidepressant Medicine Use in the Look AHEAD (Action for Health in Diabetes) Clinical Trial of Weight Loss in Diabetes
Authors: Rubin Richard R. , Peyrot Mark , Gaussoin Sarah A. , Espeland Mark A. , Williamson Don , Faulconbridge Lucy F. , Wadden Thomas A. , Ewing Linda , Safford Monika , Evans-Hudnall Gina , Wing Rena R. , Knowler William C. ,   the Look AHEAD Research Group
Published: January 2013

OBJECTIVE
To study the association of depressive symptoms or antidepressant medicine (ADM) use with subsequent cardiovascular disease (CVD) risk factor status in the Look AHEAD (Action for Health in Diabetes) trial of weight loss in type 2 diabetes.

RESEARCH DESIGN AND METHODS
Participants (n = 5,145; age [mean ± SD] 58.7 ± 6.8 years; BMI 35.8 ± 5.8 kg/m2) in two study arms (intensive lifestyle [ILI], diabetes support and education [DSE]) completed the Beck Depression Inventory (BDI), reported ADM use, and were assessed for CVD risk factors at baseline and annually for 4 years. Risk factor–positive status was defined as current smoking, obesity, HbA1c &gt;7.0% or insulin use, and blood pressure or cholesterol not at levels recommended by expert consensus panel or medicine to achieve recommended levels. Generalized estimating equations assessed within-study arm relationships of elevated BDI score (≥11) or ADM use with subsequent year CVD risk status, controlled for demographic variables, CVD history, diabetes duration, and prior CVD risk status.

RESULTS
Prior year elevated BDI was associated with subsequent CVD risk factor–positive status for the DSE arm (A1C [odds ratio 1.30 (95% CI 1.09–1.56)]; total cholesterol [0.80 (0.65–1.00)]; i.e., protective from high total cholesterol) and the ILI arm (HDL [1.40 (1.12–1.75)], triglyceride [1.28 (1.00–1.64)]). Prior year ADM use predicted subsequent elevated CVD risk status for the DSE arm (HDL [1.24 (1.03–1.50)], total cholesterol [1.28 (1.05–1.57)], current smoking [1.73 (1.04–2.88)]) and for the ILI arm (A1C [1.25 (1.08–1.46)], HDL [1.32 (1.11–1.58)], triglycerides [1.75 (1.43–2.14)], systolic blood pressure [1.39 (1.11–1.74)], and obesity [1.46 (1.22–2.18)]).

CONCLUSIONS
Aggressive monitoring of CVD risk in diabetic patients with depressive symptoms or who are treated with ADM may be warranted.
The effect of July admission on inpatient outcomes following spinal surgery
Authors: McDonald Jennifer S. , Clarke Michelle J. , Helm Gregory A. , Kallmes David F. 
Published: January 2013

Object
The presence of a “July effect,” where the influx of new residents and fellows at teaching hospitals every July may negatively affect patient care and outcomes, is widely debated. The authors used the Nationwide Inpatient Sample (NIS) to identify all cases of spinal surgery and examine outcomes among patients who underwent surgery in July compared with those who underwent surgery in other months.

Methods
Spinal surgery hospitalizations from 2001 to 2008 were identified in the NIS by extracting relevant ICD-9 codes. Rates of in-hospital mortality, discharge to a long-term care facility, and postoperative complications were compared between admission months and between teaching and nonteaching hospitals using the Wilcoxon rank-sum test, Fisher exact test, and multivariate regression analysis.

Results
Compared with patients admitted in other months, patients who were admitted to teaching hospitals in July for spinal surgery showed a similar likelihood of in-hospital mortality (OR 0.94 [95% CI 0.78–1.11], p = 0.46), reaction to implanted device/instrumentation (OR 0.88 [95% CI 0.77–1.02], p = 0.09), and postoperative wound dehiscence (OR 1.12 [95% CI 0.94–1.33], p = 0.25). A significantly higher likelihood of discharge to a long-term care facility (OR 1.03 [95% CI 1.00–1.07], p = 0.0467) and postoperative infection (OR 1.11 [95% CI 1.05–1.17], p = 0.0341) was observed in teaching hospitals in July compared with other months; however, incidence rates were similar regardless of admission month. Higher-risk patients (Charlson score ≥ 2) admitted to teaching hospitals in July had a similar likelihood of all outcomes regardless of admission month.

Conclusions
This study of nationwide hospitalizations demonstrates that the influx of new residents and fellows in July has a negligible effect on periprocedural outcomes following spinal surgery.
Relaparotomy in Obstetrics and Gynaecology Department of Faridpur Medical College Hospital - Experience in One Year
Authors: Alam Irin Parveen , Mahbuba Dr. , Das Shila Rani 
Published: January 2013

After abdominal surgery some patient's needs relaparotomy for complications developed postoperatively. Aim of this study was to determine the risk factors causing re-laparotomy, the indications, management and outcomes of relaparotomy admitting in Obstetrics and Gynaecology department in Faridpur Medical College Hospital, a tertiary referral hospital where all complicated patients are referred for management from surrounding districts hospital. It was a cross sectional study done during the period of January 2011 to December 2011, All the cases among which relaparotomy were done after primary surgery were recorded using a protocol prepared for the study. Data was analyzed. Total 6304 patients were admitted in emergency way in Obstetrics and Gynaecology department of Faridpur Medical College Hospital. Among them 1864 patients undergone emergency operations, here 15 patients needed re-laparotomy. The incidence of re-laparotomy was 0.80%. Indications of relaparotomy included internal hemorrhage, postpartum hemorrhage (PPH), retained foreign body, incorrect diagnosis at first laparotomy, intraabdominal collection of pus and urine, Rectus sheath haematoma and burst abdomen. Often more than one procedure was needed to manage the cases. Re-laparotomy causes much morbidity & mortality with increase in hospital stay and cost. Careful selection of cases for primary operation, expertise of the surgeon, good surgical technique and careful postoperative follow-up can reduce the need for re-laparotomy. DOI: http://dx.doi.org/10.3329/fmcj.v7i2.13503 Faridpur Med. Coll. J. 2012;7(2):75-78
A Case Report on Recurrent Lepra Reaction-Type 2
Authors: Ali Md Yusuf , Mahmood Reaz , Barman Rakhal Chandra , Islam M M Shahin Ul 
Published: January 2013

Lepra Reactions (LR) comprises immunologically mediated inflammatory states that cause considerable morbidity. Type-2 LR occurs exclusively in patients with the lepromatous end of the leprosy spectrum (BL-LL). In 90% of the cases it follows during or after completion of chemotherapy, generally within 2 years. Here we report a case of type-2 LR. He is a twenty years old fisherman with history of hypopigmented skin lesion 3 years back and was treated as a case of lepromatous Leprosy (LL). After six months of completion of treatment he developed type-2 LR presenting with recurrent bouts of fever, polyarthritis, erythema nodusum, orchitis, mononeuritis multiplex and was treated in Faridpur Medical College Hospital (FMCH) on three occasions within last one and half years. DOI: http://dx.doi.org/10.3329/fmcj.v7i2.13524 Faridpur Med. Coll. J. 2012;7(2):93-97
La vérification sociétale des entreprises du SBF 120 : l'impact de la structure de propriété et du conseil d'administration
Authors: Gillet-Monjarret Claire , Martinez Isabelle 
Published: January 2013

Résumé Quelle est l’influence de la structure de propriété et de la composition du conseil d’administration (CA) sur la vérification sociétale volontaire ? C’est à cette question de recherche que nous tentons ici de répondre. L’étude empirique porte sur les entreprises du SBF 120 et sur la période 2007-2008. Elle révèle que la décision de vérification sociétale est influencée par la gouvernance interne : dilution du capital, actionnariat salarié, taille et indépendance du CA, existence d’un comité spécialisé DD/RSE. Outre ces éléments, la décision de vérification sociétale dépend également du secteur d’activité.
Des lesbiennes en devenir
Authors: Amari Salima 
Published: January 2013

Résumé À partir du cas de lesbiennes d’ascendance maghrébine, de leurs rapports avec leurs familles et de leur éventuel sentiment d’appartenance à la communauté gay et lesbienne en France, cet article traite de l’émergence du sujet dans la configuration complexe que forment les rapports sociaux de sexe, de race, de classe et de sexualité. Il s’appuie sur huit entretiens menés auprès de femmes âgées de 25 à 38 ans. Confrontées aux injonctions paradoxales des normes de coming-out , de loyauté filiale et d’hétéronormativité, ces femmes évoluent dans une ambivalence permanente. Une situation qui permet la construction de sujets tacites, ambivalents et incertains : des lesbiennes en devenir.
Nommer le mal est politique
Authors: Seff Isabelle 
Published: January 2013

Résumé Les évolutions de la terminologie nosographique sont porteuses d’enjeux économiques et sociétaux ; la bataille de l’autisme en fournit l’illustration. Derrière la question de son traitement qui oppose, de façon systématique et loin de la réalité des pratiques, tcc et psychanalyse, il s’agit de discréditer la pédopsychiatrie et les structures médico-sociales actuelles pour obtenir la réaffectation des moyens publics qui les financent. Cela n’est pas sans lien avec une définition extensive de l’autisme qui en fait un enjeu de masse et l’inscrit dans un continuum des troubles de l’adaptation. Vision sociétale pernicieusement ségrégationniste où le statut de l’autiste dessine en creux celui du psychotique : dans le même temps où le premier est revalorisé dans son « handicap », le second est rabattu vers la notion de dangerosité appelant la contention. À l’autiste éducable s’opposerait le psychotique qui ne l’est pas.
L'écriture, acte psychiatrique ?
Authors: Bogaert Éric 
Published: January 2013

Résumé Évolution, au cours du vieillissement de la bouteille, de l’écriture dans la pratique d’un psychiatre de secteur : de la rédaction de l’observation psychiatrique, en passant par les actes administratifs, à l’apparition du sujet du patient dans la peau dudit psychiatre, où l’acte psychiatrique apparaît, hélas, au déclin de la carrière.
Soigner sa langue
Authors: Schira Thomas 
Published: January 2013

Résumé Ce texte se propose d’interroger la thématique du langage et de son importance. Le langage aide à la construction du psychisme et de la pensée. C’est pour cela qu’il est indispensable à l’être humain. Langage et soin sont intimement liés. D’une part, parce que le bain langagier fait partie du premier soin nécessaire à la survie (psychique) du nourrisson. D’autre part, parce que dans le soin, pour soigner son travail, il faut en parler. Que faire pour parler du langage… ? À part le faire parler. Puisque le langage est attaqué sans cesse (particulièrement dans le soin) et que la seule manière d’abîmer une langue, c’est de ne pas l’utiliser, voici une tentative poétique, humoristique et politique de parler du soin et du langage.
Au-delà du besoin, le désir
Authors: Gardou Charles , Horvais Jean 
Published: January 2013

Résumé Lorsqu’une personne est touchée par une déficience, dont découle un handicap qui restreint son autonomie, on est enclin à ne voir en elle qu’un être de besoins. Son obligation de recours à autrui ou à des dispositifs spécifiques pour les satisfaire vient imposer le silence à ses désirs, dont l’expression apparaît même incongrue. On se préoccupe quasi exclusivement de déterminer ses besoins et les aides requises. Or, cette centration, occultant le rôle premier du désir, représente un danger qui menace l’action éducative et pédagogique auprès d’enfants éloignés de la « norme scolaire ». En référence à leurs manques ou carences à combler, on en vient à les identifier, selon l’expression consacrée, à leurs seuls « besoins éducatifs particuliers ». C’est cette exclusivité donnée aux besoins qu’interroge l’article de Charles Gardou et Jean Horvais, à partir de l’exemple de pratiques auprès d’adolescents atteints d’une déficience intellectuelle accueillis en institut médico-professionnel.
La chute du taux de natalité (Shoshi-ka, ) au Japon et ses liens problématiques avec la société japonaise
Authors: Aihara Masayo 
Published: January 2013

Résumé De nos jours, au Japon, le problème de la chute du taux de natalité ( Shoshi-ka , ) est associé au Bankon-ka ( , une tendance à l’élévation de l’âge du premier mariage), parce que le mariage demeure une obligation sociale : le taux des naissances hors mariage est très bas au Japon (environ 3 % en 2005). La liaison entre le Shoshi- ka et le Bankon-ka , et la persistance du mariage créent des phénomènes sociaux particuliers, par exemple le Dékichatta-kekkon ( : mariage « pressé » à la suite de la première grossesse « accidentelle ») ou le phénomène « parasite single » (jeunes gens qui ont fini leurs études et qui habitent chez leurs parents et dépendent d’eux pour leur vie quotidienne), etc. Nous examinerons les problématiques sociales qui sont à l’origine de ce Shoshi-ka en présentant ces phénomènes particuliers de la société japonaise.
Nosologie et classifications psychiatriques selon les cultures : les « syndromes liés à la culture »
Authors: Littlewood Roland 
Published: January 2013

Résumé Le concept de culture reste assez équivoque pour la psychiatrie: à la fois dénigré car considéré comme secondaire par rapport à la réalité biomédicale - mais aussi utilisé, dans le sens où une certaine idée de la culture contribue à préserver l’opposition moderne/primitif. La compréhension clinique contemporaine de la culture dérive de la distinction entre forme biologique et contenu social introduite par la médecine coloniale pour qualifier les maladies locales. Le terme de « syndromes liés à la culture » désigne aujourd’hui les pathologies extra-européennes. Les développements récents dans la nosologie anglo-américaine seront évoqués.
(S)-fuscumol and (S)-fuscumol acetate produced by a male Astyleiopus variegatus (Coleoptera: Cerambycidae)
Authors: Hughes Gabriel P. , Zou Yunfan , Millar Jocelyn G. , Ginzel Matthew D. 
Published: January 2013

AbstractWithin the family Cerambycidae (Coleoptera), (E)-6,10-dimethyl-5,9-undecadien-2-ol (fuscumol) and (E)-6,10-dimethyl-5,9-undecadien-2-yl acetate (fuscumol acetate) have been shown to attract several species in the subfamily Lamiinae. However, it is not yet clear whether beetles within the subfamily actually produce these compounds as pheromones or rather respond to them as kairomones. We report here that male Astyleiopus variegatus (Haldeman) produce both fuscumol and fuscumol acetate, suggesting that the compounds are indeed pheromones for this species. We also determined that the absolute configurations of these compounds are (S)-fuscumol and (S)-fuscumol acetate by synthesis of both enantiomers of each.
Helios+ and Helios− Cells Coexist within the Natural FOXP3+ T Regulatory Cell Subset in Humans
Authors: Himmel Megan E. , MacDonald Katherine G. , Garcia Rosa V. , Steiner Theodore S. , Levings Megan K. 
Published: January 2013

Abstract
FOXP3-expressing T regulatory cells (Tregs) can be divided into two distinct subsets: naturally occurring Tregs (nTregs) that develop in the thymus, and induced Tregs (iTregs) that differentiate in peripheral tissues upon exposure to Ag in a tolerogenic environment. Recently it has been proposed that expression of Helios, an Ikaros family transcription factor, may specifically identify nTregs, allowing specific tracking of Tregs from different origins in health and disease. Surprisingly, we found that Helios- cells can be readily identified within naive (CD45RA+CD31+CCR7+CD62L+) FOXP3+ Tregs, a finding inconsistent with the notion that lack of Helios expression identifies Ag-experienced iTregs that should express memory markers. To investigate the phenotype and function of naive Helios+ and Helios− Tregs within the nTreg population, we isolated single-cell clones from each subset. We found that both Helios+ and Helios− nTreg clones have a similar suppressive capacity, as well as expression of FOXP3 and cell surface proteins, including CD39 and CTLA-4. Helios− nTregs, however, produced significantly more CCL3 and IFN-γ compared with Helios+ nTregs. Despite increased cytokine/chemokine production, Helios− FOXP3+ nTreg clones were demethylated at the FOXP3 Treg-specific demethylated region, indicative of Treg lineage stability. When cultured under Th1-polarizing conditions, Helios+ and Helios− nTreg clones had an equal ability to produce IFN-γ. Collectively, these data show that a lack of Helios expression does not exclusively identify human iTregs, and, to our knowledge, the data provide the first evidence for the coexistence of Helios+ and Helios− nTregs in human peripheral blood.
Usage of Sphingosine Kinase Isoforms in Mast Cells Is Species and/or Cell Type Determined
Authors: Dillahunt Sandra E. , Sargent Jennifer L. , Suzuki Ryo , Proia Richard L. , Gilfillan Alasdair , Rivera Juan , Olivera Ana 
Published: January 2013

AbstractFcεRI engagement in mast cells (MCs) induces the activation of two distinct sphingosine kinase isoforms (SphK1 and SphK2) to produce sphingosine-1-phosphate, a mediator essential for MC responses. Whereas embryonic-derived SphK2-null MCs showed impaired responses to Ag, RNA silencing studies on other MC types indicated a dominant role for SphK1. Given the known functional heterogeneity of MCs, we explored whether the reported differences in SphK1 or SphK2 usage could be reflective of phenotypic differences between MC populations. Using lentiviral-based short hairpin RNA to silence SphK1 or SphK2, we found that SphK2 is required for murine MC degranulation, calcium mobilization, and cytokine and leukotriene production, irrespective of the tissue from which the MC progenitors were derived, the stage of MC granule maturity, or the conditions used for differentiation. This finding was consistent with the lack of a full allergic response in SphK2-null mice challenged to undergo passive cutaneous anaphylaxis. A redundant role for both SphKs was uncovered, however, in chemotaxis toward Ag in all MC types tested and in TNF-α production in certain MC types. In contrast, human MC responses were dependent only on SphK1, associating with a more robust expression of this isoform and a more varied representation of SphK variants relative to murine MCs. The findings show that the function of SphK1 and SphK2 can be interchangeable in MCs; however, an important determinant of SphK isoform usage is the species of origin and an influencing factor, the tissue from which MCs may be derived and/or their differentiation state.
Hepatic Stellate Cells Preferentially Induce Foxp3+ Regulatory T Cells by Production of Retinoic Acid
Authors: Dunham Richard M. , Thapa Manoj , Velazquez Victoria M. , Elrod Elizabeth J. , Denning Timothy L. , Pulendran Bali , Grakoui Arash 
Published: January 2013

AbstractThe liver has long been described as immunosuppressive, although the mechanisms underlying this phenomenon are incompletely understood. Hepatic stellate cells (HSCs), a population of liver nonparenchymal cells, are potent producers of the regulatory T cell (Treg)–polarizing molecules TGF-β1 and all-trans retinoic acid, particularly during states of inflammation. HSCs are activated during hepatitis C virus infection and may therefore play a role in the enrichment of Tregs during infection. We hypothesized that Ag presentation in the context of HSC activation will induce naive T cells to differentiate into Foxp3+ Tregs. To test this hypothesis, we investigated the molecular interactions between murine HSCs, dendritic cells, and naive CD4+ T cells. We found that HSCs alone do not present Ag to naive CD4+ T cells, but in the presence of dendritic cells and TGF-β1, preferentially induce functional Tregs. This Treg induction was associated with retinoid metabolism by HSCs and was dependent on all-trans retinoic acid. Thus, we conclude that HSCs preferentially generate Foxp3+ Tregs and, therefore, may play a role in the tolerogenic nature of the liver.