bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between the level of social participation and depressive symptoms among older Japanese adults: a cross‐sectional survey
Authors: Shimoda Takahiro , Tomida Kouki , Nakajima Chika , Kawakami Ayuka , Shimada Hiroyuki 
Published: July 2024

AbstractBackgroundSocial participation is recommended for older adults to remain actively involved in daily life. Social participation is a broad concept, ranging from ‘interacting with others without doing a specific activity with them’ to ‘actively contributing to society.’ However, previous studies have not taken into account the components of social participation. Depressive symptoms are significant outcomes in older adults. Social participation mitigates these risks owing to its association with reduced mortality and enhanced quality of life. This study aimed to examine the association between the level of social participation and depressive symptoms in community‐dwelling older adults.MethodsWe included 17 040 individuals aged ≥65 years. Social participation was categorised into Level 3, interacting with others without doing a specific activity with them; Level 4, engaging in an activity with others; Level 5, helping others; and Level 6, contributing to society, based on a previous study by Levasseur et al. Depressive symptoms were assessed using the 15‐item Geriatric Depression Scale. Logistic regression models were used to examine the association between the level of social participation and depressive symptoms.ResultsOverall, 15 069 older adults met the inclusion criteria. A higher level of social participation was associated with lower odds ratios (ORs) for depressive symptoms (Level 6 = OR: 0.43, 95% confidence interval (CI): 0.37–0.50; Level 5 = OR: 0.50, 95% CI: 0.41–0.60; and Level 4 = OR: 0.60, 95% CI: 0.52–0.69). Subgroup analyses based on age and sex yielded similar results across all participants.ConclusionsAmong older adults in Japan, a higher level of social participation was associated with lower rates of depressive symptoms. The relationship between depressive symptoms and the levels of social participation may help develop measures to reduce or prevent depressive symptoms in older adults.
Monitoring Poverty in a Data‐Deprived Environment: The Case of Lebanon
Authors: Makdissi Paul , Marrouch Walid , Yazbeck Myra 
Published: July 2024

AbstractThis paper addresses the lack of data and limited statistical capacity in the Middle East and North Africa, particularly amid Lebanon's economic collapse. We apply a novel data augmentation technique to analyze poverty when traditional income data are limited or unavailable. By adapting existing methods, we recover continuous income distributions from interval data and derive dominance conditions for such data, accounting for non‐response. The proposed approach enables robustness checks by estimating the bounds of admissible cumulative distribution functions. Our empirical analysis uses Lebanese data to perform first‐order dominance tests on these bounds, highlighting the importance of the approach. We demonstrate how alternative data sources can be leveraged for essential poverty analysis.
Stratigraphic architecture of fluvial fans shaped by downstream changes in avulsion style
Authors: Valenza Jeffery M. , Edmonds Douglas A. , Martin Harrison K. , Sifuentes Caitlin , Toby Stephan 
Published: July 2024

ABSTRACTNatural river diversion, or avulsion, controls the distribution of channels on a floodplain and channel sandstone bodies within fluvial stratigraphic architecture. Avulsions establish new flow paths and create channels through several recognized processes, or styles. These include reoccupying existing channels, or annexation, downcutting into the floodplain, or incision, and constructing new channels from crevasse‐splay distributary networks, or progradation. Recent remote sensing observations show that avulsion style changes systematically moving downstream along modern fluvial fans but, to date, no studies have assessed the significance of these trends on fluvial fan stratigraphy. Here, spatiotemporal changes in avulsion stratigraphy are investigated within the Salt Wash Member of the Morrison Formation, deposited in the Cordilleran foreland basin during the Late Jurassic epoch. Measured sections and photographic panels were analysed from 23 locations across the Salt Wash extent. Avulsion style was identified in the stratigraphic record by the basal contact of a channel storey with underlying strata: channel–channel contacts indicate annexation, channel–floodplain contacts indicate incision and channel–heterolithic contacts indicate progradation. Contact types change downstream, such that channel–channel and channel–floodplain contacts dominate proximal locations, while channel–heterolithic contacts become increasingly prevalent downstream. Outcrop results were compared to a numerical model of fluvial fan formation and remote‐sensing analysis of avulsions on modern fans. In both additional datasets, channels in proximal fan positions tend to avulse via annexation, reoccupying abandoned channels, while channels in more distal positions tend to avulse via increasingly significant progradation. These findings suggest a relationship between newly recognized downstream changes in avulsion style and well‐established downstream changes in fluvial fan architecture. Furthermore, this suggests that fan architecture can inform interpretations of ancient fluvial dynamics, including avulsion behaviour, and that avulsions can cause stratigraphically significant and measurable changes to fan architecture.
Monetary policy and heterogeneous price effects in the United Kingdom
Authors: Ilori Ayobami E. , Dery Cosmas , Murgia Lucia M. , Nsafoah Dennis 
Published: July 2024

AbstractThis paper examines the heterogeneous effects of monetary policy on consumer prices in the United Kingdom. We estimate a proxy Structural Vector Autoregressive (SVAR) model, using extended high‐frequency monetary surprises from Cesa‐Bianchi et al. (European Economic Review, 123, 2020, 103375) to instrument shifts in UK monetary policy. We then analyze the impulse responses for various components of the UK Consumer Price Index. Our findings reveal that while monetary policy tightening leads to a persistent decline in aggregate consumer prices, the impact on disaggregated components is highly heterogeneous. Notably, we observe that energy price changes offset movements in food, beverage, and tobacco prices, resulting in identical responses of core and headline consumer CPIH inflation measures. The contrasting effects across different CPI components highlight the importance of examining disaggregated data when assessing the transmission of monetary policy to consumer prices.
Organization and organizationality of corruption
Authors: Jancsics David 
Published: July 2024

AbstractCorrupt actors operate in an environment with numerous mechanisms designed to expose and punish their illegal behavior. Therefore, they organize their activity to reduce risk and uncertainty surrounding the situation, which takes place within and beyond a formal hierarchy. This article approaches the subject from a multidisciplinary perspective, applying theories of organization and organizationality—such as communicative constitution of organizations, social organization, partial organization, complete organization, neopatrimonialism, and patronage–to explain the organizing element of different forms of corruption. By introducing the ideas of the organization and organizationality, this study presents a new dimension of corruption and provides new insight into the scholarship on the topic.
Parent‐reported problematic lying tendencies and BIS/BAS activity as predictors of children's antisocial lie‐telling
Authors: Tong Donia , Caivano Oksana , Lavoie Jennifer , Talwar Victoria 
Published: July 2024

AbstractThe current study examined whether age and parental reports of children's problematic lying, behavioural inhibition system (BIS) activity, and reward responsiveness predicted children's antisocial lie‐telling. Children from mostly middle and upper‐class Canadian families (ages 3–12, M = 6.23, SD = 2.52) participated in a modified Temptation Resistance Paradigm (TRP), where they were given opportunities to tell a self‐protective lie (to conceal a transgression) and an instrumental lie (to obtain a reward). Parents completed measures of their children's problematic lying tendencies, BIS activity, and reward responsiveness. Age and parent‐reported problematic lying and BIS activity were significant predictors of lie‐telling behaviour in the TRP. Instrumental liars were younger than dual liars (those who told both types of lies) and truth‐tellers. Truth‐tellers had lower parent‐reported problematic lying than instrumental and dual liars but not self‐protective liars. Dual liars had lower parent‐reported BIS activity than truth‐tellers; there were no differences among truth‐tellers, self‐protective liars, and instrumental liars. This study contributes to our understanding of the role of temperamental factors in children's lie‐telling propensity and the predictive utility of parent‐reported predictors for children's antisocial lie‐telling propensity. Our findings indicate that parents can identify and potentially address their children's problematic lying using their knowledge about their children's temperamental traits.
A new disease mapping method for improving data completeness of syndromic surveillance with high missing rates
Authors: Liao Yilan , Shi Yuanhao , Fan Zhirui , Zhu Zhiyu , Huang Binghu , Du Wei , Wang Jinfeng , Wang Liping 
Published: July 2024

AbstractSyndromic surveillance is a type of public health surveillance that utilizes nonspecific indicators or symptoms associated with a particular disease or condition to detect and track disease outbreaks early. However, data completeness has been a significant challenge for syndromic surveillance systems in many countries. Incomplete data may make it difficult to accurately identify anomalies or trends in surveillance data. In this study, a new disease mapping method based on a high‐accuracy, low‐rank tensor completion (HaLRTC) algorithm is proposed to estimate the quarterly positivity rate of the human influenza virus (IFV) based on highly insufficient 2010–2015 respiratory syndromic surveillance data from the subtropical monsoon region of China. The HaLRTC algorithm is a spatiotemporal interpolation method applied to fill in missing or incomplete data using a low‐rank tensor structure. The results show that the accuracy (R2 = 0.880, RMSE = 0.037) of the proposed method is much higher than that of three traditional disease mapping methods: Cokriging, hierarchical Bayesian, and sandwich estimation methods. This study provides a new disease mapping approach to improve the quality and completeness of data in syndrome surveillance or other familiar systems with a large proportion of missing data.
Correctness of assertion and validity of inference
Authors: Martin‐Löf Per 
Published: July 2024

AbstractThis is a slightly edited transcript of a lecture given by Per Martin‐Löf on 26 October 2022 at the Rolf Schock Symposium in Stockholm. In 2020, the Rolf Schock Prize in Logic and Philosophy was awarded to Dag Prawitz and Per Martin‐Löf, and the symposium was organised in their honour. The transcript was prepared by Ansten Klev and edited by the author.
Hotspot Exon 15 Mutations in BRAF Are Uncommon in Feline Tumours
Authors: Kuroki Kei , Hoang Christine Tran , Rogic Anita M. , Rindt Hans , Simenson Angelynn , Noall Lucie G. , Bryan Jeffrey N. , Johnson Gayle C. , Chu Shirley 
Published: July 2024

ABSTRACTBRAF is one of multiple RAF proteins responsible for the activation of the MAPK cell signalling cascade involved in cell growth, differentiation, and survival. A hotspot BRAFV600E mutation, in exon 15, was determined to be a driver in 100% hairy cell leukaemias, 50%–60% of human melanomas, 30%–50% of human thyroid carcinomas and 10%–20% of human colorectal carcinomas. The orthologous BRAFV595E mutation was seen in 67% and 80% of canine bladder transitional cell carcinomas and prostatic adenocarcinomas, respectively. Since veterinary and human cancers exploit similar pathways and BRAF is highly conserved across species, BRAF can be expected to be a driver in a feline cancer. Primers were developed to amplify exon 15 of feline BRAF. One hundred ninety‐six feline tumours were analysed. Sanger sequencing of the 211 bp PCR amplicon was done. A BRAF mutation was found in one tumour, a cutaneous melanoma. The mutation was a BRAFV597E mutation, orthologous to the canine and human hotspot mutations. A common synonymous variant, BRAFT586T, was seen in 23% (47/196) of tumours. This variant was suspected to be a single nucleotide polymorphism. BRAF was not frequently mutated in common feline tumours or in tumour types that frequently harbour BRAF mutations in human and canine cancers. As is seen in canine cancer genomics, the mutational profile in feline tumours may not parallel the histologic equivalent in human oncology.
Investigation of ocular surface parameters in dogs with different cephalic conformations using veterinary ocular surface analyzer (OSA‐VET)
Authors: Li Yan‐Hui , Martins Bianca , Lin Chung‐Tien 
Published: July 2024

AbstractObjectiveTo compare ocular surface parameters in dogs with different cephalic conformations and evaluate correlations among tests.Animals StudiedSixty‐eight privately owned dogs.ProceduresThe study categorized canine eyes into three groups based on the craniofacial ratio (CFR): brachycephaly (≤0.52), mesocephaly (>0.52 to <0.67), and dolichocephaly (≥0.67). All eyes were examined using an ocular surface analyzer (OSA‐VET) to determine lipid layer thickness (LLT) of the tear film, tear meniscus height (TMH), non‐invasive tear breakup time (NIBUT), and meibomian gland loss rate of the lower eyelids (MGLRL). Schirmer tear test 1 (STT‐1) and tear film breakup time (TBUT) were also performed. Statistical analyses involved one‐way ANOVA, Kruskal–Wallis H test, post hoc Holm–Sidak test, and Pearson correlation coefficient.ResultsWhile STT‐1 showed no significant difference among dog groups, brachycephalic dogs had significantly lower values in TBUT, NIBUT, and LLT, and a higher TMH, compared to mesocephalic and dolichocephalic dogs. Additionally, brachycephalic dogs exhibited a significantly higher MGLRL than dolichocephalic dogs. Correlations among tests were generally weak to moderate (r < .6) except for a strong correlation between CFR and LLT (r = .641, p < .001), and between TBUT and NIBUT (r = .899, p < .001).ConclusionsBrachycephalic morphology predisposes dogs to a significantly thinner lipid layer and diminished tear film stability, likely due to factors such as impaired meibomian gland function and increased ocular exposure compared to other cephalic conformations, thereby increasing their risk of keratoconjunctivitis sicca (KCS). OSA‐VET shows a valuable tool to provide more comprehensive and precise diagnosis for canine ocular surface disorders.
On the variance of the mean width of random polytopes circumscribed around a convex body
Authors: Bakó‐Szabó Alexandra , Fodor Ferenc 
Published: July 2024

AbstractLet be a convex body in in which a ball rolls freely and which slides freely in a ball. Let be the intersection of i.i.d. random half‐spaces containing chosen according to a certain prescribed probability distribution. We prove an asymptotic upper bound on the variance of the mean width of as . We achieve this result by first proving an asymptotic upper bound on the variance of the weighted volume of random polytopes generated by i.i.d. random points selected according to certain probability distributions, then, using polarity, we transfer this to the circumscribed model.
Myths and methodologies: Assessing glycaemic control and associated regulatory mechanisms in human physiology research
Authors: Wrench Elizabeth , Subar Daren A. , Bampouras Theodoros M. , Lauder Robert M. , Gaffney Christopher J. 
Published: July 2024

AbstractAccurate measurements of glycaemic control and the underpinning regulatory mechanisms are vital in human physiology research. Glycaemic control is the maintenance of blood glucose concentrations within optimal levels and is governed by physiological variables including insulin sensitivity, glucose tolerance and β‐cell function. These can be measured with a plethora of methods, all with their own benefits and limitations. Deciding on the best method to use is challenging and depends on the specific research question(s). This review therefore discusses the theory and procedure, validity and reliability and any special considerations of a range common methods used to measure glycaemic control, insulin sensitivity, glucose tolerance and β‐cell function. Methods reviewed include glycosylated haemoglobin, continuous glucose monitors, the oral glucose tolerance test, mixed meal tolerance test, hyperinsulinaemic euglycaemic clamp, hyperglycaemic clamp, intravenous glucose tolerance test and indices derived from both fasting concentrations and the oral glucose tolerance test. This review aims to help direct understanding, assessment and decisions regarding which method to use based on specific physiology‐related research questions.
Cold Gas Spraying Copper Metal on AlN Ceramics as an Alternative to Thick Direct Bond Copper Substrates for Power Electronics
Authors: Guerrero-Fernandez Margie , Quintero Pedro , Ozdemir Ozan Cagatay 
Published: July 2024

Abstract
This study investigates the use of cold gas spraying (CGS) as a low-temperature additive manufacturing method to bond copper onto aluminum nitride (AlN) substrates for electronic packaging of high-power applications. While the direct bond copper (DBC) technique is commonly used, it has limitations due to the large mismatch in the coefficient of thermal expansion, which affects substrate reliability. This work employed CGS to mechanically bond Cu on AlN. The study explores the effect of multiple sprays, spray angle, and spraying direction on deposition thickness, coating surface roughness, and deposited volume through a factorial design of experiments (DOE). The results, based on optical and scanning electron microscopy combined with profilometry data, showed that coatings sprayed at a 60 deg angle had a smoother profile topography and less surface roughness than those sprayed at a 90 deg angle. After depositing ten layers, a surface roughness (Sa) of around 30 μm and a coating thickness of over 300 μm were successfully attained. These findings provide valuable insights into the processing factors affecting the growth and quality of copper coatings on AlN substrates via multiple sprays, thus enabling the realization of CGS technology as a potential solution to DBC substrates for electronic packaging of wide-bandgap semiconductors.
Variable Area Jet Impingement for Enhanced Junction Temperature Control of High-Power Electronics
Authors: Whitt Reece , Huitink David 
Published: July 2024

Abstract
Convective heat transfer by jet impingement cooling offers a suitable solution for high heat flux applications. Compared to techniques that rely on bulk conduction in series with convection, direct liquid impingement reduces the thermal resistance between power device hot spots and the coolant. Although capable of highly efficient cooling, static impingement devices must be designed for the worst-case cooling requirements for a transient power profile. This can result in wasted hydraulic performance. Aircraft, highway vehicles, and heavy machinery fall into this category where a substantial factor of safety is required. This work proposes a method for improving power electronics reliability by limiting temperature fluctuations at reduced coolant pressure requirements during transient power cycling using a variable area jet. Single phase jet impingement cooling is implemented in an active control scheme using a variable diameter iris mechanism as the primary nozzle architecture. In addition to pressure drop and temperature control, the active nozzle structure introduces the ability to create pulsating jet flows to further enhance the heat transfer compared to fixed-geometry nozzles. The key underlying fluid mechanics characteristic of pulsating flows is the effect of disrupting the thermal boundary layer on the electrical device surface. By introducing a variable diameter jet, eddy formation can be fine-tuned for optimal boundary layer disruption. Using the definition of the Strouhal number, vortex shedding created by the nonsteady jet flows is directly correlated with the resulting Nusselt number as a function of the iris kinematics. An experimental apparatus for jet impingement thermal-fluid testing is used to evaluate the Nusselt number versus Strouhal number for a parametric study of variable diameter iris configurations. The apparatus utilizes a voice coil actuator to achieve sine and square waveforms, to vary the amplitude of actuation, and to vary the mean of actuation. Finally, power cycling with a single emulated hot spot is performed to estimate the reliability increase as a result of maintaining constant junction temperatures with the active jet impingement scheme.
Development of a luciferase-based Gram-positive bacterial reporter system for the characterization of antimicrobial agents
Authors: Lam Nga Man , Tsang Tsz Fung , Qu Jiayi , Tsang Man Wai , Tao Yuan , Kan Cheuk Hei , Zou Qingyu , Chan King Hong , Chu Adrian Jun , Ma Cong , Yang Xiao 
Published: July 2024

ABSTRACT

Mechanistic investigations are of paramount importance in elucidating the modes of action of antibiotics and facilitating the discovery of novel drugs. We reported a luciferase-based reporter system using bacterial cells to unveil mechanisms of antimicrobials targeting transcription and translation. The reporter gene
Nluc
encoding NanoLuciferase (NanoLuc) was integrated into the genome of the Gram-positive model organism,
Bacillus subtilis
, to generate a reporter strain BS2019. Cellular transcription and translation levels were assessed by quantifying the amount of
Nluc
mRNA as well as the luminescence catalyzed by the enzyme NanoLuc. We validated this system using three known inhibitors of transcription (rifampicin), translation (chloramphenicol), and cell wall synthesis (ampicillin). The
B. subtilis
reporter strain BS2019 successfully revealed a decline in
Nluc
expression by rifampicin and NanoLuc enzyme activity by chloramphenicol, while ampicillin produced no observable effect. The assay was employed to characterize a previously discovered bacterial transcription inhibitor, CUHK242, with known antimicrobial activity against drug-resistant
Staphylococcus aureus
. Production of
Nluc
mRNA in our reporter BS2019 was suppressed in the presence of CUHK242, demonstrating the usefulness of the construct, which provides a simple way to study the mechanism of potential antibiotic candidates at early stages of drug discovery. The reporter system can also be modified by adopting different promoters and reporter genes to extend its scope of contribution to other fields of work.

IMPORTANCE
Discovering new classes of antibiotics is desperately needed to combat the emergence of multidrug-resistant pathogens. To facilitate the drug discovery process, a simple cell-based assay for mechanistic studies is essential to characterize antimicrobial candidates. In this work, we developed a luciferase-based reporter system to quantify the transcriptional and translational effects of potential compounds and validated our system using two currently marketed drugs. Reporter strains generated in this study provide readily available means for identifying bacterial transcription inhibitors as prospective novel antibacterials. We also provided a series of plasmids for characterizing promoters under various conditions such as stress.