bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of an Arts at Home program for people living with dementia: Learnings from key stakeholders
Authors: O'Connor Claire M. C. , Poulos Roslyn G. , Heldon Michelle , Preti Costanza , Beattie Elizabeth , Poulos Christopher J. 
Published: July 2024

AbstractIssue AddressedThis study explores experiences of people with dementia and family carers who participated in an Arts on Prescription at Home (AoP@Home) program, artists who delivered the AoP@Home program and the managers who coordinated the AoP@Home programs.MethodsSemi structured interviews were conducted with the three stakeholder groups to explore experiences around implementation of AoP@Home. Interview questions were specific to each stakeholder group, and designed to capture the varied experiences around coordinating, delivering and participating in AoP@Home programs when delivered as a standard service offering. Qualitative content analysis was applied to evaluate the transcripts.ResultsA total of 13 stakeholders participated in interviews: four people living with dementia and four family carers, three artists and two AoP program managers. Three overarching themes emerged across the stakeholder groups: ‘what worked well’, ‘challenges’ and ‘moving forward’.ConclusionsAoP@Home has potential as an important offering for community‐dwelling people with dementia who may no longer be able to access group‐based community programs. As AoP@Home is expanded, ongoing implementation monitoring and quality improvement will be essential to ensure maximal applicability of the program across the community aged care sector.So What?The implementation of a new AoP@home service has been examined, and finds consumer satisfaction (person with dementia and their carer), and support from staff (artists and program managers). The novel nature of the service, however, requires considerable work to educate service referrers about the service and its benefits.
X‐ray‐ultraviolet–visible‐near‐infrared photoresponses realized in a lead‐free hybrid perovskite ferroelectric through light‐induced ferro‐pyro‐phototronic effect
Authors: Fu Dongying , Ma Yanli , Wu Shufang , Pan Lin , Wang Qi , Zhao Ruifang , Zhang Xian‐Ming , Luo Junhua 
Published: July 2024

AbstractDue to the built‐in electric field induced by spontaneous polarization in hybrid perovskite (HP) ferroelectrics, the devices based on them exhibit excellent performance in self‐powered photodetection. However, most of the self‐powered photodetector are made of lead‐based HP ferroelectrics and have a relatively narrow photoresponse waveband. Although lead‐free HPs solve the problem of lead toxicity, their optoelectronic performance is inferior to that of lead‐based HPs and photoresponse waveband is limited by its optical band gap, which hinders their further application. To solve this problem, herein, a lead‐free HP ferroelectric (HDA)BiI5 (HDA is hexane‐1,6‐diammonium) with large spontaneous polarization shows an enhanced photocurrent and achieves x‐ray‐ultraviolet–visible‐near‐infrared (x‐ray‐UV–Vis–NIR) photoresponse through the ferro‐pyro‐phototronic (FPP) effect. The ferroelectric, pyroelectric, and photovoltaic characteristics coupled together in a single‐phase (HDA)BiI5 ferroelectric is an effective way to improve the performance of the devices. What is particularly attractive is that the FPP effect not only improves the optoelectronic performance of (HDA)BiI5, but also achieves broadband photoresponses beyond its optical absorption range. Especially, the current boosting with an exceptional contrast of ~1100% and 2400% under 520 and 637 nm, respectively, which is associated with FPP effect. Meanwhile, single crystal self‐powered photodetector based on (HDA)BiI5 also exhibit significant FPP effects even under high‐energy x‐ray, which owns an outstanding sensitivity of 170.7 μC Gy−1 cm−2 and a lower detection limit of 266 nGy s−1 at 0 V bias. Therefore, it is of great significance to study the coupling of multiple physical effects and improve device performance based on lead‐free HP ferroelectrics.image
Convolutional neural networks can detect orthostatic hypotension in Parkinson's disease using resting‐state functional near‐infrared spectroscopy data
Authors: Lee Seung Hyun , Paik Seung‐Ho , Kang Shin‐Young , Phillips Zephaniah , Kim Jung Bin , Kim Byung‐Jo , Kim Beop‐Min 
Published: July 2024

AbstractNeurological disorders such as Parkinson's disease (PD) often adversely affect the vascular system, leading to alterations in blood flow patterns. Functional near‐infrared spectroscopy (fNIRS) is used to monitor hemodynamic changes via signal measurement. This study investigated the potential of using resting‐state fNIRS data through a convolutional neural network (CNN) to evaluate PD with orthostatic hypotension. The CNN demonstrated significant efficacy in analyzing fNIRS data, and it outperformed the other machine learning methods. The results indicate that judicious input data selection can enhance accuracy by over 85%, while including the correlation matrix as an input further improves the accuracy to more than 90%. This study underscores the promising role of CNN‐based fNIRS data analysis in the diagnosis and management of the PD. This approach enhances diagnostic accuracy, particularly in resting‐state conditions, and can reduce the discomfort and risks associated with current diagnostic methods, such as the head‐up tilt test.
Reactivation by novel pyridinium oximes of rat serum and skeletal muscle acetylcholinesterase inhibited by organophosphates
Authors: Bennett Joshua P. , Meek Edward C. , Chambers Janice E. 
Published: July 2024

AbstractThe treatment of organophosphate (OP) anticholinesterases currently lacks an effective oxime reactivator of OP‐inhibited acetylcholinesterase (AChE) which can penetrate the blood‐brain barrier (BBB). Our laboratories have synthesized novel substituted phenoxyalkyl pyridinium oximes and tested them for their ability to promote survival of rats challenged with lethal doses of nerve agent surrogates. These previous studies demonstrated the ability of some of these oximes to promote 24‐h survival to rats challenged with a lethal level of highly relevant surrogates for sarin and VX. The reactivation of OP‐inhibited AChE in peripheral tissues was likely to be a major contributor to their efficacy in survival of lethal OP challenges. In the present study, twenty of these novel oximes were screened in vitro for reactivation ability for AChE in rat skeletal muscle and serum using two nerve agent surrogates: phthalimidyl isopropyl methylphosphonate (PIMP, a sarin surrogate) and 4‐nitrophenyl ethyl methylphosphonate (NEMP, a VX surrogate). The oximes demonstrated a range of 23%–102% reactivation of AChE in vitro across both tissue types. Some of the novel oximes tested in the present study demonstrated the ability to more effectively reactivate AChE in serum than the currently approved oxime, 2‐PAM. Therefore, some of these novel oximes have the potential to reverse AChE inhibition in peripheral target tissues and contribute to survival efficacy.
Pharmacokinetics of Human Plasma‐Derived Antithrombin in Pediatric Patients Supported on Extracorporeal Membrane Oxygenation
Authors: Jung Dawoon , Procaccini David , Roem Jennifer , Patel Ankur , Ng Derek K. , Bembea Melania M. , Gobburu Jogarao V. S. 
Published: July 2024

AbstractExtracorporeal membrane oxygenation (ECMO) support of critically ill pediatric patients is associated with increased risk of thromboembolic events, and unfractionated heparin is used commonly for anticoagulation. Given reports of acquired antithrombin (AT) deficiency in this patient population and associated concern for heparin resistance, AT activity measurement and off‐label AT replacement have become common in pediatric ECMO centers despite limited optimal dosing regimens. We conducted a retrospective cohort study of pediatric ECMO patients (0 to <18 years) at a single academic center to characterize the pharmacokinetics (PK) of human plasma‐derived AT. We demonstrated that a two‐compartment turnover model appropriately described the PK of AT, and the parameter estimates for clearance, central volume, intercompartmental clearance, peripheral volume, and basal AT input under non‐ECMO conditions were 0.338 dL/h/70 kg, 38.5 dL/70 kg, 1.16 dL/h/70 kg, 40.0 dL/70 kg, and 30.4 units/h/70 kg, respectively. Also, ECMO could reduce bioavailable AT by 50% resulting in 2‐fold increase of clearance and volume of distribution. To prevent AT activity from falling below predetermined thresholds of 50% activity in neonates and 80% activity in older infants and children, we proposed potential replacement regimens for each age group, accompanied by therapeutic drug monitoring.
Validity and reproducibility of the ARL‐RSI score to assess psychological readiness before returning to sport after lateral ankle sprain
Authors: Picot Brice , Grimaud Olivier , Rauline Gauthier , Haidar Ibrahim , Moussa Mohamad K. , Hardy Alexandre 
Published: July 2024

AbstractPurposeAlthough multiple scales exist to evaluate psychological readiness before returning to sport post‐lateral ankle sprain (LAS), no score has been validated specifically for LAS or chronic ankle instability. The main aim of the study is to evaluate the validity and reproducibility of the ankle ligament reconstruction‐return to sport injury (ALR‐RSI) scale in assessing psychological readiness after LAS and its ability to identify patients who can return to their preinjury level.MethodsA total of 64 patients (35 females and 29 males; 33.8 ± 13.2 years) who recently experienced an acute LAS were included in this study. All patients participated in a predictive validation component of the study and were assessed at 2 and 4 months following an LAS. The ALR‐RSI was completed twice by 20 patients at a 7‐day interval to evaluate the reliability of the score in patients suffering from LAS.ResultsThe ALR‐RSI was significantly (p < 0.001) and positively correlated with the other scores. The correlation was strong with the Foot and Ankle Ability Measure Sports: r = 0.77; 95% confidence interval [CI]: 0.78–0.83) and moderate with the American Orthopaedic Foot and Ankle Society (r = 0.69; 95% CI: 0.60–0.78) and the Foot and Ankle Ability Measure Activities of Daily Living Scores (r = 0.63; 95% CI: 0.51–0.72). Two‐month ALR‐RSI scores had good ability for predicting nonreturners at 4 months (area under the curve = 0.76; 95% CI: 0.6–0.9; p = 0.005). A Youden index of 0.51 was observed at an ALR‐RSI score of 46%, corresponding to a sensitivity of 67% and specificity of 83%. Test–retest reliability of the ALR‐RSI was excellent, with an ICC of 0.98 (95% CI: 0.96–0.99), a standard error of measurement of 3.02% and a minimum detectable change of 8.37%.ConclusionsThe results of the current study validated the ALR‐RSI as an important questionnaire to assess psychological readiness to return to sport after LAS.Level of EvidenceLevel II prospective cohort study.
Textured insoles may improve some gross motor balance measures but not endurance measures in children with motor coordination issues. A randomised controlled feasibility trial
Authors: Banwell Helen A. , Tsiros Margarita , Coventry Jessica , Ryan Narelle , Williams Cylie M. 
Published: July 2024

AbstractBackgroundMotor coordination concerns are estimated to affect 5%–6% of school‐aged children. Motor coordination concerns have variable impact on children's lives, with gait and balance often affected. Textured insoles have demonstrated positive impact on balance and gait in adults with motor coordination disorders related to disease or the ageing process. The efficacy of textured insoles in children is unknown. Our primary aim was to identify the feasibility of conducting a randomised controlled trial involving children with motor control issues. The secondary aim was to identify the limited efficacy of textured insoles on gross motor assessment balance domains and endurance in children with movement difficulties.MethodsAn assessor‐blinded, randomised feasibility study. We advertised for children between the ages of 5–12 years, with an existing diagnosis or developmental coordination disorder or gross motor skill levels assessed as 15th percentile or below on a norm‐referenced, reliable and validated scale across two cities within Australia. We randomly allocated children to shoes only or shoes and textured insoles. We collected data across six feasibility domains; demand (recruitment), acceptability (via interview) implementation (adherence), practicality (via interview and adverse events), adaptation (via interview) and limited efficacy testing (6‐min walk test and balance domain of Movement ABC‐2 at baseline and 4 weeks).ResultsThere were 15 children randomised into two groups (eight received shoes alone, seven received shoes and textured insoles). We experienced moderate demand, with 46 potential participants. The insoles were acceptable, however, some parents reported footwear fixture issues requiring modification. The 6‐min walk test was described as problematic for children, despite all but one child completing. Social factors impacted adherence and footwear wear time in both groups. Families reported appointment locations and parking impacting practicality. Underpowered, non‐significant small to moderate effect sizes were observed for different outcome measures. Improvement in balance measures favoured the shoe and insole group, while gait velocity increase favoured the shoe only group.ConclusionOur research indicates that this trial design is feasible with modifications such as recruiting with a larger multi‐disciplinary organisation, providing velcro shoe fixtures and using a shorter timed walk test. Furthermore, progressing to a larger well‐powered randomised control trial is justified considering our preliminary, albeit underpowered, efficacy findings.Trial RegistrationThis trial was retrospectively registered with the Australian and New Zealand Clinical Trial Registration: ACTRN12624000160538.
バイケイソウ誤食により徐脈と低血圧，低体温を来した1例(A case of bradycardia, hypotension, and hypothermia caused by Veratrum album poisoning)
Authors: 亜紗美 大山 , 沙由里 後藤 , 光子 鈴木 , 吏栄 全田 , 剛 鈴木 , 誠 小野寺 , 憲 伊関 
Published: July 2024

要旨バイケイソウはべラトルムアルカロイドを含む有毒植物の一つであり，春の関東～東北地方で食中毒例が多い。今回，オオバギボウシ（ウルイ）との誤食により重篤な徐脈，低血圧，低体温を来した症例を経験したので報告する。症例：63歳の男性，渓流釣り後に自宅で飲酒していたところ，嘔吐と脱力感が出現した。血圧が測定できず体温が32℃台であったため，救急要請された。病着時の意識は清明で，バイタルサインは体温35.7℃，呼吸数15/分，脈拍数30/分，血圧70/37mmHg，SpO2 92%（酸素6L/分投与）だった。心電図は洞性徐脈で，対症療法としてアトロピン0.5mgやエフェドリン40mg投与を行ったが効果は一時的だった。ドパミン持続投与を開始したところ，循環動態は安定した。問診で「自生していたウルイを調理して摂取した」と発言があり，食した山菜を確認するとバイケイソウを誤食したことが判明し，食中毒による循環不全の診断となった。摂取翌日にドパミンは終了し，第3病日に退院となった。考察：バイケイソウの中毒症状は嘔吐と血圧低下が特徴的で，アトロピンやカテコラミンの投与をはじめとした全身管理が必要になる。低体温を来した症例は過去に類を見なかった。適切な対応がなされた場合の死亡例はなく，的確な診断と早期治療が求められる。誤食を疑うエピソードを聴取しない限り診断に近づくことは難しいため，正確な問診が鍵となる。
Tentative identification of phytochelatins, their derivatives, and Cd‐phytochelatin complexes in Ocimum basilicum L. roots by Paper Spray Mass Spectrometry
Authors: Teles Vânia de Lourdes das G. , de Sousa Giselle V. , Augusti Rodinei , Costa Letícia M. 
Published: July 2024

AbstractAn unprecedented and direct PS‐MS (paper spray ionization mass spectrometry) method was proposed for the detection of native peptides, that is, glutathiones (GSHs), homoglutathiones (hGSHs), and phytochelatins (PCs), in basil (Ocimum basilicum L.) roots before and after cadmium exposure. The roots were submitted to cold maceration followed by sonication with formic acid as the extractor solvent for sample preparation. PS‐MS was used to analyze such extracts in the positive mode, and the results allowed for the detection of several GSHs, hGSHs, and PCs. Some of these PCs were not distinguished in the control samples, that is, basil roots not exposed to cadmium. Other PCs were noticed in both types of roots, uncontaminated and cadmium‐contaminated, but the intensities were higher in the former samples. Moreover, long‐time exposure to cadmium stimulated the formation of some of these PCs and their cadmium complexes. The results, therefore, provided some crucial insights into the defense mechanism of plants against an external stress condition due to exposure to a toxic heavy metal. The present study represents a promising alternative to investigate other crucial physiological processes in plants submitted to assorted stress conditions.
Characterization of CRESS‐DNA viruses in human vaginal secretions: An exploratory metagenomic investigation
Authors: Ramos Endrya do Socorro Foro , Tozetto‐Mendoza Tania Regina , Bortoletto Pietro , Ferreira Noely Evangelista , Honorato Layla , Barbosa Erick Matheus Garcia , Luchs Adriana , Linhares Iara M. , Spandorfer Steven D. , Leal Elcio , da Costa Antonio Charlys , Witkin Steven S. , Mendes‐Correa Maria Cassia 
Published: July 2024

AbstractThe Phylum Cressdnaviricota consists of a large number of circular Rep‐encoding single‐stranded (CRESS)‐DNA viruses. Recently, metagenomic analyzes revealed their ubiquitous distribution in a diverse range of eukaryotes. Data relating to CRESS‐DNA viruses in humans remains scarce. Our study investigated the presence and genetic diversity of CRESS‐DNA viruses in human vaginal secretions. Vaginal swabs were collected from 28 women between 29 and 43 years old attending a fertility clinic in New York City. An exploratory metagenomic analysis was performed and detection of CRESS‐DNA viruses was confirmed through analysis of near full‐length sequences of the viral isolates. A phylogenetic tree was based on the REP open reading frame sequences of the CRESS‐DNA virus genome. Eleven nearly complete CRESS‐DNA viral genomes were identified in 16 (57.1%) women. There were no associations between the presence of these viruses and any demographic or clinical parameters. Phylogenetic analysis indicated that one of the sequences belonged to the genus Gemycircularvirus within the Genomoviridae family, while ten sequences represented previously unclassified species of CRESS‐DNA viruses.Novel species of CRESS‐DNA viruses are present in the vaginal tract of adult women. Although they be transient commensal agents, the potential clinical implications for their presence at this site cannot be dismissed.
Reconstruction of the historic time course of blood‐borne virus contamination of clotting factor concentrates, 1974–1992
Authors: McClure C. Patrick , Kean Kai , Reid Kaitlin , Mayne Richard , Fu Michael X. , Rajendra Piya , Gates Shannah , Breuer Judy , Harvala Heli , Golubchik Tanya , Tarr Alexander W. , Irving William L. , Makris Michael , Simmonds Peter 
Published: July 2024

AbstractFactor VIII and IX clotting factor concentrates manufactured from pooled plasma have been identified as potent sources of virus infection in persons with hemophilia (PWHs) in the 1970s and 1980s. To investigate the range and diversity of viruses over this period, we analysed 24 clotting factor concentrates for several blood‐borne viruses. Nucleic acid was extracted from 14 commercially produced clotting factors and 10 from nonremunerated donors, preserved in lyophilized form (expiry dates: 1974–1992). Clotting factors were tested by commercial and in‐house quantitative PCRs for blood‐borne viruses hepatitis A, B, C and E viruses (HAV, HBV, HCV, HEV), HIV‐ types 1/2, parvoviruses B19V and PARV4, and human pegiviruses types 1 and 2 (HPgV‐1,‐2). HCV and HPgV‐1 were the most frequently detected viruses (both 14/24 tested) primarily in commercial clotting factors, with frequently extremely high viral loads in the late 1970s–1985 and a diverse range of HCV genotypes. Detection frequencies sharply declined following introduction of virus inactivation. HIV‐1, HBV, and HAV were less frequently detected (3/24, 1/24, and 1/24 respectively); none were positive for HEV. Contrastingly, B19V and PARV4 were detected throughout the study period, even after introduction of dry heat treatment, consistent with ongoing documented transmission to PWHs into the early 1990s. While hemophilia treatment is now largely based on recombinant factor VIII/IX in the UK and elsewhere, the comprehensive screen of historical plasma‐derived clotting factors reveals extensive exposure of PWHs to blood‐borne viruses throughout 1970s‐early 1990s, and the epidemiological and manufacturing parameters that influenced clotting factor contamination.
Applications of culinary medicine in the pediatric gastroenterology, hepatology, and nutrition field
Authors: Weston Sharon , Weisbrod Vanessa , Duro Debora 
Published: July 2024

Key points

Culinary medicine can enhance a provider's ability to counsel patients using “food as medicine” to treat disease‐specific areas.
Applying culinary medicine in pediatric gastroenterology is a practical way to empower patients to better manage their condition, minimize gastrointestinal symptoms, and promote a healthier relationship with food.
Surface‐enhanced Raman scattering of Cis‐(dicyanomethylene) squarate ion on a silver substrate
Authors: Marques Flávia C. , Milán‐Garcés Erix A. , de Oliveira Vanessa E. , Georgopoulos Stéfanos L. , Andrade Gustavo F. S. , de Oliveira Luiz Fernando C. 
Published: July 2024

AbstractThere has been increasing interest in the use of squaraines with different physicochemical properties. However, their applications in nanoplasmonics are limited. For that, detailed information on the interactions of squaraines with plasmonic nanostructures is required. In this work, we have studied the adsorption of the squaraine cis‐dicyanomethylene squarate (CDSQ) on the surface of Ag nanoparticles (AgNP). We have combined normal Raman, surface‐enhanced Raman scattering (SERS), and DFT calculations to get insights into the configuration of its adsorption. DFT calculations have been carried out using simplified models of different adsorption geometries for comparison with the results of the SERS experiments. A comparison between the relative intensities of the normal Raman and SERS spectra indicates that CDSQ is adsorbed perpendicular to the AgNP surface. The predicted spectra suggest that CDSQ is chemically adsorbed on the silver surface through one of its N atoms.
Tuber crops could be a potential food component for lowering starch digestibility and estimated glycemic index in rice
Authors: Kumar Awadhesh , Mahapatra Soumya , Nayak Lopamudra , Biswal Monalisha , Sahoo Upasana , Lal Milan Kumar , Nayak Amaresh Kumar , Pati Kalidas 
Published: July 2024

AbstractBACKGROUNDRice is considered a high estimated glycemic index (eGI) food because of its higher starch digestibility, which leads to type II diabetes and obesity as a result of a sedentary life style. Furthermore, the incresaing diabetes cases in rice‐consuming populations worldwide need alternative methods to reduce the glycemic impact of rice, with dietary prescriptions based on the eGI value of food being an attractive and practical concept. Rice is often paired with vegetables, pulses, tubers and roots, a staple food group in Africa, Latin America and Asia, which are rich in fibre and health‐promoting compounds.RESULTSRice from four categories (high protein, scented, general and pigmented) was analyzed for eGI and resistant starch (RS) content. Among the genotypes, Improved Lalat had the lowest eGI (53.12) with a relatively higher RS content (2.17%), whereas Hue showed the lowest RS (0.19%) with the highest eGI (76.3) value. The addition of tuber crops to rice caused a significant lowering of eGI where the maximum beneficial effect was shown by elephant foot yam (49.37) followed by yam bean (53.07) and taro (54.43).CONCLUSIONThe present study suggests that combining rice with suitable tuber crops can significantly reduce its eGI value, potentially reducing the burden of diet‐associated lifestyle diseases particularly diabetics. © 2024 Society of Chemical Industry.