bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disparities in Telehealth Uptake for Developmental-Behavioral Pediatric Assessments by Preferred Family Language: A Developmental Behavioral Pediatrics Research Network Study
Authors: Wallis Kate E. , Kennelly Annie , Wozniak Sarah N. , Craig Sansanee , Flaherty Carina M. , Cacia Jaclyn , Christiansen Audrey , Cordero Lucero , Ortiz Priscilla , Kellom Katherine S. , Stefanski Kristen ,   DBPNet Steering Committee
Published: July 2024

Abstract:

Objective:
Owing to the coronavirus disease 2019 (COVID-19) pandemic, many developmental-behavioral pediatric (DBP) practices adopted telehealth for care delivery. However, telehealth access and use for families with a preferred language other than English (PLOE) is an equity concern. Therefore, our study objective is to compare rates of telehealth utilization and visit completion by preferred family language among patients seen for DBP assessments during the COVID-19 pandemic.

Methods:
We completed a descriptive chart review using electronic health record data at 4 academic DBP practices to examine visits for patients up to 5 years seen for new-patient appointments between April 2020 and April 2021. We compared rates of in-person and telehealth visits by preferred family language and visit outcome (completed or missed).

Results:
A total of 3241 visits were scheduled between April 2020 and April 2021; 48.2% were for in-person and 51.8% for telehealth. Families reported the following languages: 90.5% English, 6.2% Spanish, and 3.3% other language. Missed visits accounted for 7.6% of scheduled visits. The relative percentage of in-person versus telehealth visits varied significantly by site (p < 0.001) and preferred family language (p < 0.001). English-speaking patients had 2.10 times the odds of being scheduled for telehealth compared with patients with PLOE, adjusting for site. Statistically significant differences were not found for visit outcome (completed or missed) by visit type (in-person or telehealth) (p = 0.79), including after accounting for PLOE status (p = 0.83).

Conclusion:
At the height of the pandemic, most English-speaking families were scheduled for new DBP evaluations by telehealth, but fewer families with PLOE were. Attention to language to ensure telehealth access equity is critical.
SHORT-TERM REACTIVATION OF RETINOPATHY OF PREMATURITY AFTER PRIMARY RANIBIZUMAB TREATMENT
Authors: Strawbridge Jason , Cheng John Y. , Gundlach Bradley S. , Gillespie Tessa , Karmouta Reem , Khitri Monica , Chu Alison , Tsui Irena 
Published: July 2024

Purpose:
Investigate risk factors for short-term reactivation of retinopathy of prematurity (ROP) after intravitreal ranibizumab (IVR) therapy and determine safety and efficacy of repeat injections.

Methods:
Retrospective chart review study of patients screened for ROP as inpatients between 2013 and 2023 who received IVR within the UCLA health care system. Primary outcomes were rates and timing of short-term ROP reactivation, defined as repeat worsening of ROP to stage 2 or 3 before 52 weeks postmenstrual age, as well as risk factors for reactivation. Other outcomes included adverse events and rates of reactivation after a second intravitreal injection.

Results:
Eighty-two eyes of 43 patients received primary IVR 0.25 mg/0.025 cc for type 1 ROP. Thirteen patients (22 eyes) (30.2% of patients, 26.8% of eyes) developed short-term reactivation an average of 7.2 weeks ± 1.7 weeks after treatment. Increased reactivation risk was associated with zone I disease (odds ratio 6.23, 95% CI, 1.35–28.7, P = 0.019), lower postmenstrual age at first injection (odds ratio 1.64, 95% CI, 1.19–2.26; P = 0.003), and lower gestational age at birth (odds ratio 1.80, 95% CI, 1.04–3.13, P = 0.037). Of the 13 patients that received repeat injections, five required laser treatment for a second reactivation (11.6% of patients receiving IVR). No eyes developed retinal vascular occlusion, endophthalmitis, or cataract.

Conclusion:
Repeat injections may be required after primary IVR for aggressive ROP. Repeat IVR treatment for ROP is effective and poses few ophthalmic adverse events, although additional reactivation remains a risk.
A Survey of Current Gonioscopy Practice in the United Kingdom
Authors: Khan Shaheryar Ahmed , Zhou Sean , Niyadurupola Nuwan 
Published: July 2024

Précis:
This survey highlights a deficiency in gonioscopy practices across the UK, particularly in the utilization of indentation gonioscopy and training of junior ophthalmologists. Recommendations include standardizing practice and enhancing training opportunities to improve patient care.

Objective:
Gonioscopy is an important general skill learned and practiced by all grades of ophthalmologists. The aim of this study is to discover the general attitude, perception, and practice of gonioscopy among ophthalmologists in the UK.

Materials and Methods:
A National gonioscopy survey was carried out by utilizing an anonymous electronic questionnaire of 18 questions. The questionnaire was electronically distributed online, using the survey tool, Microsoft 2016 “MS Forms” to all grades of ophthalmologists in the UK.

Results:
A total of 146 responses were analyzed. Overall, 89% of the participants felt “comfortable in performing slit lamp gonioscopy,” but only 38% of junior trainees (ophthalmic specialist trainees years 1–3) felt comfortable in gonioscopy. Only 13% of the junior trainees felt they had adequate training in performing gonioscopy compared with 68% of the total respondents. Surprisingly, the majority of consultants (58%) did not “strongly agree” to be confident in assessing the angle and its configuration on gonioscopy. The most commonly used gonioscopic lens in this survey was the Zeiss four-mirror gonio lens, but only 38% of participants performed indentation gonioscopy routinely. The majority of the participants utilized the modified Shaffer’s classification for gonioscopy. Fewer than expected numbers performed gonioscopy routinely for new patients with glaucoma.

Conclusion:
This survey suggests that gonioscopy is not being performed according to the UK national recommendations, and few ophthalmologists perform indentation gonioscopy. Additional gonioscopy training in the curriculum may be helpful.
Updating the paradigm of prophylactic abdominal drainage following pancreatoduodenectomy
Authors: Li Zhenli , Zhang Yibing , Ni Yuanzhi , Li Liang , Xu Lindi , Guo Yang , Zhu Shuaishuai , Tang Yufu 
Published: July 2024

Background:
Prophylactic abdominal drainage (PAD) is considered a routine procedure after pancreatoduodenectomy (PD) to prevent and detect severe complications at an early stage. However, the drainage itself may cause adverse consequences. Thus, the optimal strategy of PAD after PD remains controversial.

Methods:
The present paper summarizes the latest research on the strategies of PAD following PD, mainly focusing on 1) the selective placement of PAD, 2) the optimal drainage types, 3) the early removal of drainage (EDR), and 4) novel strategies for PAD management.

Results:
Accurate stratifications based on the potential risk factors of clinically relevant-postoperative pancreatic fistula (CR-POPF) facilitates the selective placement of PAD and the implementation of EDR, with postoperative outcomes superior or similar to routine PAD placement. Both active and passive drainage methods are feasible in most patients after PD, with similar prognostic outcomes. Novel predictive models with accurate, dynamic, and individualized performance further guide the management of PAD and afford a better prognosis.

Conclusions:
Evidence-based risk stratification of CR-POPF aids in the management of PAD in patients undergoing PD. Novel dynamic and individualized PAD strategies might be the next hotspot in drain-relevant explorations.
Clinical Nurses’ Perceptions of a “Brain-Friendly” Peer Feedback Program
Authors: Wisner Kirsten , Lopez Megan 
Published: July 2024

Background:
While clinicians routinely observe issues with safety and quality, they may not always speak up and intervene. Peer feedback supports nurses to speak up about errors or near misses and actively improve nursing care quality. Effective peer feedback requires addressing barriers to speaking up.

Purpose:
The purpose of this mixed methods study was to evaluate a‘brain-friendly‘peer feedback program´s effect on clinical nurses´ perceptions of peer review.

Methods:
Nurses were surveyed before and after the implementation of a peer feedback program that integrated social cognitive neuroscience principles. Open comments were analyzed using thematic analysis.

Results:
Responses to nearly half of survey questions improved. Thematic analysis identified institutional and personal barriers to peer feedback use, revealing the personal and social complexity of speaking up.

Conclusions:
Social cognitive neuroscience may enhance peer feedback programs. Research using immersive qualitative methods is needed to better understand factors supporting or impeding peer feedback.
Toward Zero New HIV Infections in Amsterdam in 2026: Building Bridges Between Community Organizations, Undocumented Migrants, and Sexual Health Care Providers
Authors: Teijema Martha T. , van der Meij Laura L.M. , de Groot Steffen M. , Hoogerbrugge Annette , Hoornenborg Elske 
Published: July 2024

Background
In the 4 largest cities in the Netherlands, an estimated 400 people live with undiagnosed HIV, including 170 in Amsterdam. Amsterdam targets having zero new HIV infections in 2026. Undocumented migrants are disproportionately affected by HIV and often contract HIV after migration. Moreover, they often experience difficulties accessing health care. The aim of this study was to analyze the outcomes of an HIV/sexually transmitted infection testing program for undocumented migrants through community based testing.

Methods
Between May 2021 and January 2022, data for this cross-sectional study were collected during outreach testing activities of the Amsterdam Center for Sexual Health of the Public Health Service, and the NGO Doctors of the World. Activities were organized in collaboration with migrant partner organizations. Participants were tested free-of-charge for HIV, syphilis, gonorrhea, chlamydia, and, if indicated, hepatitis B and C. Before testing, a health care provider–administered questionnaire was filled out.

Results
A total of 126 people from 22 countries were tested for HIV during 28 outreach activities. Mean age was 37 (IQR 32–43). Forty-nine people (39%) were additionally tested, (through self-sampling) for chlamydia, gonorrhea and syphilis, 42 (33%) for Hepatitis B and 14 (11%) for Hepatitis C. We found zero new HIV infections and 5 positive chlamydia cases.
Reaching 52 HIV first time testers and 19 first time testers since migration shows the importance of these activities. The number of participants tested were lower than initially expected due to lower attendance per testing day for various reasons.

Conclusions
To increase the likelihood of reaching undocumented migrants for HIV/sexually transmitted infection testing and linkage to care, focus should be on on-site provider-initiated testing, e.g. during outreach health care activities, and on easy access to centers for sexual health. Collaboration between health care providers and community stakeholders is essential.
Subfascial Transaxillary Breast Augmentation: Critical Evaluation of a 25-Year Review of 1015 Consecutive Cases
Authors: Munhoz Alexandre Mendonça , de Azevedo Marques Neto Ary 
Published: July 2024

Background:
Subfascial (SF) pocket breast augmentation (BA) has gained popularity, whereas the transaxillary approach (TAA) offers the benefit of an inconspicuous scar. Previous reports on both techniques involved limited follow-up/samples, and few clinical studies specifically address surgical technique and outcomes following primary and secondary BA. The purpose of this study was to assess outcomes from the SF TAA technique in a large series of patients who underwent primary and secondary BA.

Methods:
A retrospective cohort of patients who underwent BA between 1999 and 2024 was identified. The primary outcome was occurrence of incision and implant/pocket complications. Regression logistic analysis evaluated risk factors including age, body mass index, smoking, implant surface/volume, and fat grafting.

Results:
The cohort contained 1015 patients (mean age, 28.5 ± 7.3 years), and the average follow-up was 77.6 ± 38.6 months. In primary BA, 212 patients (23.4%) experienced at least 1 complication, most frequently capsular contracture. More complications were seen in secondary BA (P = 0.016). Multivariate regression identified body mass index less than 18.5 kg/m2 as a significant risk factor for incision complications, whereas textured surface (OR, 2.70; P < 0.001) and implant volume greater than 350 cc (OR, 2.79; P < 0.001) were risk factors for implant/pocket complications.

Conclusions:
Despite extensive research on BA procedures, studies on SF TAA procedures are limited and have not analyzed long-term outcomes following primary/reoperative operations. These results demonstrate that SF TAA is a reliable technique, and the data are compatible with other studies using different BA approaches. Knowledge of the axillary and pectoralis fascia anatomy allows surgeons to safely implement the SF TAA technique and minimize risk.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, III.
Modification of Low-Septal-Strip Septoplasty to Reduce Hump Recurrence in Dorsal Preservation Rhinoplasty
Authors: Çelik Vasfi , Tuluy Yavuz 
Published: July 2024

Background:
Among the problems encountered in dorsal preservation rhinoplasty are residual hump and hump recurrence. In this study, the authors performed a modification to lower strip resection and fixation of the septum, and investigated the clinical results of these modifications on hump recurrence.

Methods:
The study included 231 patients who underwent dorsal preservation rhinoplasty with low-septal-strip septoplasty between November of 2021 and February of 2023. Closed dorsal preservation rhinoplasty was performed with low-septal-strip septoplasty in 72 patients (31.2%), and modified low-septal-strip septoplasty was performed in 159 patients (68.8%). All cases were primary rhinoplasty. Demographic data, complication rates, revision operations, and follow-up periods were analyzed retrospectively.

Results:
The mean follow-up period was 9.68 ± 4.02 months (range, 3 to 16 months). Patient sex and age did not differ statistically significantly between the groups (P > 0.05). Complications were observed in 8 of 231 of the patients (3.5%). The complications in the low-septal-strip septoplasty group (P = 0.012) were statistically significantly higher than in those in the modified low-septal-strip septoplasty group (P < 0.05). The incidence of recurrent hump complications in the low-septal-strip septoplasty group (P = 0.029) was statistically significantly higher than in the modified group (P < 0.05).

Conclusions:
Septum fixation is one of the most important parts of dorsal preservation rhinoplasty surgery and must be performed properly. In the authors’ modification, the risk of recurrent hump is reduced, as sufficient septum fixation is achieved.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, III.
Osseous Maxillary Reconstruction with Immediate Dental Implant Placement: An Optimized Workflow for the Oncologic Patient
Authors: Matros Evan , Kim Leslie N. , Poveromo Luke , Polanco Thais , Rosen Evan , Ganly Ian , Boyle Jay , Cohen Marc , Randazzo Joseph D. , Shahzad Farooq , Patel Snehal G. , Nelson Jonas A. , Cordeiro Peter G. , Allen Robert J. 
Published: July 2024

Background:
Maxillary reconstruction is a complex undertaking characterized by a 3-dimensional surgical site with deficiencies in multiple tissue types. Before virtual surgical planning (VSP), bony reconstruction was inaccurate and inefficient; thus, reconstructions defaulted to soft-tissue flaps or obturators. The current study describes an efficient and accurate approach to bony maxillary reconstruction with immediate dental implant placement (IDIP).

Methods:
A reconstructive workflow was developed for osseous reconstruction to improve functional and aesthetic outcomes. Critical aspects include VSP, 3-dimensionally printed plates, and IDIP. Review of a prospectively maintained database identified patients who underwent osseous maxillary reconstruction with a fibula flap and immediate dental implants from 2017 to 2022, with a focus on oncologic characteristics and reconstructive outcomes.

Results:
During the study, 20 patients underwent maxillary reconstruction with VSP and IDIP. One dental implant of 55 failed to osseointegrate, and no flaps were lost. Three patients experienced partial loss of the fibula skin island; 1 required palatal closure with a radial forearm flap, and 2 were managed with outpatient débridement. Fifteen patients achieved either an interim or final retained dental prosthesis. All prostheses achieved acceptable aesthetic results without the instability associated with non–bone-borne devices (eg, dentures/obturators). No patients experienced delays in oncologic treatment.

Conclusions:
VSP technology has enabled surgeons to replace like with like to achieve better outcomes with acceptable morbidity for maxillary defects. IDIP provides all patients an opportunity for a fixed prosthesis even though not all complete the process. This maxillary reconstruction workflow can be safely accomplished in oncologic patients with promising and effective early results.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, IV.
Question Mark Reconstruction Method for Synchronous Multiple Tumor Defects in the Scalp
Authors: Çağli Hasan Basri , Ateşşahin Fatih Berk , Menderes Adnan , Vayvada Haluk 
Published: July 2024

Introduction:
Synchronous tumors on the scalp are a common condition, and reconstruction methods of their defects should be considered together. The authors believe that the rotation flap combined with the Burow triangle, whose final scar looks like a question mark, can provide excellent results for suitable multiple tumor defects.

Materials and Methods:
From September 2022 to June 2023, the question mark reconstruction method was performed on 8 patients.

Results:
The mean age of the patients was 74.1 years (range, 69–80 y). All tumors were removed with sufficient negative margins. Hair-bearing skin was preserved in all patients, with only a narrow and acceptable scarred alopecic area.

Discussion:
The question mark reconstruction method can provide excellent results for synchronous scalp defects by minimizing dog-ear deformity and unnecessary tissue excision and providing a “like-with-like” reconstruction.
Rapid neurostimulation at micron scale with optically controlled thermal-capture technique
Authors: Romshin Alexey M. , Aseyev Nikolay A. , Idzhilova Olga S. , Koryagina Alena A. , Zeeb Vadim E. , Vlasov I. I. , Balaban Pavel M. 
Published: July 2024

AbstractPrecise control of cellular temperature at the microscale is crucial for developing novel neurostimulation techniques. Here, we study the effect of local heat on the electrophysiological properties of cells at the subcellular level using a cutting-edge micrometer-scale thermal probe, the diamond heater-thermometer (DHT). Experiments on primary neuronal cultures and HEK293 cells revealed that millisecond heat pulses could induce reversible changes in membrane potential and elicit ionic displacement currents. At local temperatures close to 50 °C, a rapid increase in cellular response by an order of magnitude was observed, attributed to local phase changes in the phospholipid membrane at the point of contact with the DHT. This allows the cell membrane to be effectively and reproducibly captured by temperature, referred to as thermal-capture mode (TCM). Once transition to TCM occurred, even lower temperatures (<35 °C) elicited depolarization up to 10 mV in neurons, sufficient for triggering action potentials with rates up to 30 Hz. Additionally, the impact of high temperatures beyond the physiological range on the electrophysiology of the cell was assessed. These findings enhance the understanding of how local heat affects cellular functions and provide insights into the thermal modulation of cell activity.
Actions obey Weber’s law when precision is evaluated at goal attainment
Authors: Camponogara Ivan , Volcic Robert 
Published: July 2024

AbstractWeber’s law, the psychophysical principle stating that the just noticeable difference (JND), which is inversely related to sensory precision, increases proportionally with the magnitude of a stimulus, impacts all domains of human perception, but it is violated in visually guided grasping actions. The underlying reasons for this dissociation between perception and action are still debated, and various hypotheses have been put forward, including a different coding of visual size information for perception and action, the use of positional information to guide grasping, biomechanical factors, or sensorimotor calibration. To contrast these hypotheses, we investigated Weber’s law in a new action task, the two-finger pointing task. Participants reached and touched two targets positioned at different distances apart by using their index finger and thumb. Consistent with Weber’s law, we found that the standard deviation (SD) of the final inter-finger separation, serving as a measure analogous to the JND, increased with larger inter-target distances. These findings suggest that, when considering measures strongly related with the attainment of the action goal, Weber’s law is regularly at play.
YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1 mediated reprogramming of bone mesenchymal stem cells
Authors: Noorizadeh Rahil , Sax Barbara , Javaheri Tahereh , Sarikas Branka Radic , Fock Valerie , Kauer Maximilian , Bykov Aleksandr , Suresh Veveeyan , Schlederer Michaela , Kenner Lukas , Weber Gerhard , Mikulits Wolfgang , Halbritter Florian , Moriggl Richard , Kovar Heinrich 
Published: July 2024

AbstractEwing sarcoma (EwS) is an aggressive cancer of adolescents in need of effective treatments. Insulin like growth factor (IGF) 1 was previously reported an autocrine growth factor for EwS, but only 10% of patients responded to IGF-1 receptor blockade. Although presumed to originate from mesenchymal progenitors during bone development, targeting of the EwS driver oncogeneEWS::FLI1to the mesenchymal lineage in a conditional mouse model did not result in tumor formation but led to skeletal malformations and perinatal death. We report that transient exposure to IGF-1 concentrations mimicking serum levels during puberty reprogrammed limb-derived mesenchymal cells ofEWS::FLI1-mutant mice to stable transformation and tumorigenicity. We identified a modular mechanism of IGF-1-driven tumor promotion in the early steps of EwS pathogenesis, in which Yap1 plays a central role. Pharmacologic Yap1/Tead inhibition reversed the transformed phenotype of EWS::FLI1 expressing cells. Our data provide a rationale for combined IGF-1R and YAP/TEAD inhibition in the treatment of EwS patients.Graphical Abstract