bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of coordination mechanisms based on information and communication technologies on cross-level clinical coordination: A scoping review
Authors: Campaz-Landazábal Daniela , Vargas Ingrid , Vázquez María-Luisa 
Published: August 2024

Background Coordination mechanisms based on information and communication technologies (ICTs) are gaining attention, especially since the pandemic, due to their potential to improve communication between health professionals. However, their impact on cross-level clinical coordination remains unclear. The aim is to synthesize the evidence on the impact of ICT-based coordination mechanisms on clinical coordination between primary care and secondary care (SC) doctors and to identify knowledge gaps. Methods A scoping review was conducted by searching for original articles in six electronic databases and a manual search, with no restrictions regarding time, area, or methodology. Titles and abstracts were screened. Full texts of the selected articles were reviewed and analysed to assess the impact of each mechanism, according to the cross-level clinical coordination conceptual framework. Results Of the 6555 articles identified, 30 met the inclusion criteria. All had been conducted in high-income countries, most ( n = 26) evaluated the impact of a single mechanism – asynchronous electronic consultations via electronic health records (EHR) – and were limited in terms of design and types and dimensions of cross-level clinical coordination analysed. The evaluation of electronic consultations showed positive impacts on the appropriateness of referrals and accessibility to SC, yet the qualitative studies also highlighted potential risks. Studies on other mechanisms were scarce (shared EHR, email consultations) or non-existent (videoconferencing, mobile applications). Conclusions Evidence of the impact of ICT-based mechanisms on clinical coordination between levels is limited. Rigorous evaluations are needed to inform policies and strategies for improving coordination between healthcare levels, thus contributing to high-quality, efficient healthcare.
Evaluating ChatGPT responses to frequently asked patient questions regarding periprosthetic joint infection after total hip and knee arthroplasty
Authors: Hu Xiaojun , Niemann Marcel , Kienzle Arne , Braun Karl , Back David Alexander , Gwinner Clemens , Renz Nora , Stoeckle Ulrich , Trampuz Andrej , Meller Sebastian 
Published: August 2024

Background Patients access relevant information concerning their orthopaedic surgery resources through multiple information channels before presenting for clinical treatment. Recently, artificial intelligence (AI)-powered chatbots have become another source of information for patients. The currently developed AI chat technology ChatGPT (OpenAI LP) is an application for such purposes and it has been rapidly gaining popularity, including for patient education. This study sought to evaluate whether ChatGPT can correctly answer frequently asked questions (FAQ) regarding periprosthetic joint infection (PJI). Methods Twelve FAQs about PJI after hip and knee arthroplasty were identified from the websites of fifteen international clinical expert centres. ChatGPT was confronted with these questions and its responses were analysed for their accuracy using an evidence-based approach by a multidisciplinary team. Responses were categorised in four groups: (1) Excellent response that did not require additional improvement; (2) Satisfactory responses that required a small amount of improvement; (3) Satisfactory responses that required moderate improvement; and (4) Unsatisfactory responses that required a large amount of improvement. Results From the analysis of the responses given by the chatbot, no reply received an ‘unsatisfactory’ rating; one did not require any correction; and the majority of the responses required low (7 out of 12) or moderate (4 out of 12) clarification. Although a few responses required minimal clarification, the chatbot responses were generally unbiased and evidence-based, even when asked controversial questions. Conclusions The AI-chatbot ChatGPT was able to effectively answer the FAQs of patients seeking information around PJI diagnosis and treatment. The given information was also written in a manner that can be assumed to be understandable by patients. The chatbot could be a valuable clinical tool for patient education and understanding around PJI treatment in the future. Further studies should evaluate its use and acceptance by patients with PJI.
Factors Associated with Hospital Length of Stay among VTE Cases: Insights from the i-RegVed Registry
Authors: Aggarwal Sumit , Rulu Peteneinuo ,   i-RegVed Team, Tabassum Heena 
Published: August 2024

Introduction: Venous thromboembolism (VTE) is a multifactorial condition and one of the leading causes of mortality and disability. The present study explores the factors associated with hospitalization duration among different types of venous thromboembolism diagnoses, such as deep vein thrombosis (DVT), pulmonary embolism (PE), and other forms of thrombosis. Methods: The data included participants with VTE admitted to 13 hospitals within pan-India from June 2022 to December 2023 to the i-RegVed registry, where socio-demographic data, clinical history, and various factors associated with hospital length of stay (LOS) were included for analyses. Multilinear regression was performed to explore the factors associated with hospital LOS among VTE conditions such as DVT, PE, forms of thrombosis other than PE and DVT, and all VTE diagnoses. Results: A total of 633 participants were included in the study, with 55% being males, and 28.9% being homemakers. Longer hospital LOS was significantly associated with age (β = −.09, P < .05), sex (β = 3.21, P < .05), and non-communicable diseases (β = 3.51, P < .05) among participants with DVT and among participants with at least one of the VTE diagnoses, age (β = −.12, P < .001) and anticoagulant use (β = −2.49, P < .05) was significantly associated. Conclusion: The findings provide insights into the factors influencing hospital outcomes among participants with different types of VTE, highlighting the importance of age and comorbidities in predicting the hospital LOS.
The Utility and Necessity for Radiographic Follow-Up After Arthroplasty for Geriatric Neck of Femur Fractures
Authors: Koh Don Jun Rui , Yeo Kuei Siong Andy , Kon Kam King Charles , Moo Ing How 
Published: August 2024

Background Hip fractures are a common and debilitating condition posing not only a huge health care but also socioeconomic burden. Surgical management for a neck of femur fracture is typically with arthroplasty in the form of total hip arthroplasty or hip hemiarthroplasty. Serial radiographs are typically performed routinely as part of follow-up to look for complications, although their clinical utility in asymptomatic patients is yet to be validated. Our paper therefore aims to review the utility and necessity of radiographic follow-up following arthroplasty for NOF fractures. Materials and Methods Patients who underwent operative management for acute fragility neck of femur fractures in the year from 1st January 2018 to 31st December 2018 at the author’s institution were identified. All patients who underwent surgery, and had at least one pre and one post-operative plain film radiograph of the affected hip were included in this study. Exclusion criteria included patients who had undergone surgery for chronic fractures, avascular necrosis of the femoral head, mortality within 1 year, peri-prosthetic fractures, pathological fractures from metastases, had concomitant injuries, or had inaccessible or incomplete records. Clinical records were assessed for the number of visits, an abnormal presenting history or clinical examination, as well as changes in management of the patient. The number and type of radiographs were also assessed, and each radiograph analyzed for abnormal findings. Results A total of 157 patients were included in our study with a mean age of 79.5 at the time of surgery, and a mean follow up of 17.3 months. Data was collected from 626 clinical visits and a total of 973 radiographs. The 3 abnormal radiographic series identified with a corresponding normal consult did not result in a change of management for the patient. A negative change in management was only observed in 1 patient with an abnormal consult and a corresponding normal radiograph. Conclusion Post-operative complications following arthroplasty for NOF fractures are likely to result in a symptomatic presentation of the patient. Routine radiographic follow-up provides limited utility in asymptomatic patients and should only be performed if clinically indicated.
Outcomes of ACL Reconstruction Utilizing Supercritical CO2-Sterilized Allografts
Authors: Farey John E. , Salmon Lucy J. , Roe Justin P. , Russell Vivianne , Sundaraj Keran , Pinczewski Leo A. 
Published: August 2024

Background: Allograft tendons are perceived to have a high ACL graft failure rate in primary anterior cruciate ligament (ACL) reconstruction (ACLR). Historical series may be biased by graft processing methods that degrade the biomechanical properties of donor tendons such as irradiation. Supercritical carbon dioxide (SCCO2) is a validated method of terminally sterilizing biomaterials at physiological temperatures without irradiation, but in vivo use of SCCO2-processed tendon allografts for primary ACLR has not been reported to date. Hypothesis: ACLR with SCCO2 allografts would result in acceptable failure rates, subjective knee scores, and clinical evaluation at 2 years postoperatively. Study Design: Case series; Level of evidence, 4. Methods: Patients underwent primary ACLR with terminally sterilized SCCO2-processed human gracilis, peroneus longus, semitendinosus, tibialis anterior, and tibialis posterior tendon allografts. Patient demographics were collected, along with tendon donor age and sex. At 1 year postoperatively, subjective International Knee Documentation Committee (IKDC) and ACL–Return to Sport After Injury (ACL-RSI) scores were collected, as well as clinical evaluation. At 2 years postoperatively, the IKDC and ACL-RSI scores were repeated, and return to sports and further knee injuries were recorded. Results: A total of 144 patients with a medianage of 26 (IQR 14) years formed the study group. Patients were predominately male (58%). The loss to follow-up rate was 8% (n = 12). The mean age of allograft tendon donors was 37 (range 17-58) years, and the majority were male (83%). The mean allograft diameter was 8.9 ± 1.0 mm. At 2 years, ACL graft failureoccurred in 5% (n = 7). All graft failureswere in patients aged ≤25 years ( P = .007). Neither donor age (≤40 or >40 years) nor donor sex was associated with graft failure ( P > .05). The median IKDC subjective score was 95 and ACL-RSI score was 75. There were no revisions for sepsis within the first 2 years postoperatively. Conclusion: SCCO2 processing of allograft tendons demonstrated satisfactory clinical and patient-reported outcomes at 24 months postoperatively in a consecutive series of patients with primary ACLR, with similar ACL graft failure rates and subjective knee scores compared with those reported in published series of hamstring tendon autograft and fresh frozen nonirradiated allograft.
Randomized Controlled Trials Assessing Exposure Frequency Effects of Stannous Fluoride on Gingivitis
Authors: He T. , Zou Y. , Grender J. , Amini P. , Kaminski M. , Biesbrock A.R. 
Published: August 2024

Objective: To evaluate the exposure frequency effect of 0.454% stannous fluoride (SnF2) toothpaste in controlling gingivitis. Methods: Two randomized controlled trials enrolled generally healthy adults with gingivitis. The study duration was 1 mo (study 1) and 3 mo (study 2). Gingivitis was assessed using the Löe-Silness Gingival Index (LSGI) at baseline, 1 mo (both studies), and 3 mo (study 2); bleeding scores were derived from the LSGI. Study groups consisted of positive control (twice-daily use of 0.454% SnF2 toothpaste), experimental group (brushing in the morning with SnF2 toothpaste and in the evening with 0.76% sodium monofluorophosphate [SMFP] toothpaste), and negative control (twice-daily use of SMFP toothpaste). The primary endpoint was number of bleeding sites. Results: Study 1 and study 2 each enrolled and randomized 90 participants; 86 and 89 participants, respectively, completed the trials. At baseline, the mean (SD) number of bleeding sites was 47.6 (18.54) in study 1 and 41.5 (17.84) in study 2. At 3 mo (study 2), the positive control produced 51.3% fewer bleeding sites, and the experimental group produced 32.5% fewer bleeding sites versus the negative control ( P < 0.001 for both). At 1 mo, the positive control produced 45.1% (study 1) and 45.8% (study 2) fewer bleeding sites versus the negative control ( P < 0.001 for both), and the experimental group produced 33.0% (study 1) and 24.8% (study 2) fewer bleeding sites, respectively, versus the negative control ( P ≤ 0.002 for both). The benefit was observed as early as 1 mo and was consistent with 3-mo results. Conclusion: This research is to our knowledge the first to demonstrate a gingivitis-reduction response effect for the frequency of bioavailable SnF2 toothpaste use, with maximum benefit from twice-daily use, followed by a single-daily exposure versus the negative control. Clinical trial registration numbers: NCT05916508 and NCT05916521. Knowledge Transfer Statement: The results of this study can be used by dental professionals to guide their recommendations for therapeutic toothpaste for gingival health. Emphasis on the importance of twice-daily brushing with bioavailable stannous fluoride dentifrice will help patients optimize gingival health benefits achieved via self-care.
A qualitative investigation into autistic adults’ perspectives on intervention goals for autistic children
Authors: Schuck Rachel K. , Geng Alicia , Doss Yvette , Lin Florence , Crousore Hannah , Baiden Kaitlynn M. P. , Dwyer Patrick , Williams Zachary J. , Wang Mian 
Published: August 2024

Behavioral intervention programs for autistic children target a variety of goals including communication, social, academic, and daily living skills. A key component of ethical interventions is social validity, the extent to which interested parties find the program goals, procedures, and outcomes acceptable. However, past research indicates that social validity is rarely assessed from the autistic point of view. Thus, while intervention goals may be acceptable from parent or clinician perspectives, little is known regarding autistic individuals’ views of these goals. In this study, autistic adults were presented with common intervention goals and asked to provide written feedback on them. Though these open-ended questions were presented as an optional survey question, each goal received open-ended feedback from 120 to 189 participants (out of a possible 214 who completed the relevant survey portions). Responses were analyzed using reflexive thematic analysis by a team of nonautistic and autistic researchers. Four themes were identified: “Autistic Way of Being & The Double Empathy Problem”; “Supporting Autonomy, Self-Advocacy, and Interdependence”; “Implementation Matters,", and “Moving Beyond Behavior.” Findings will hopefully aid providers in developing intervention goals that are aligned with the perspectives of the autistic community. Lay abstract Intervention programs for autistic children aim to help children with communication, social skills, academic tasks, and everyday behaviors and activities. A major factor in ensuring these programs are ethical is “social validity,” which means ensuring that the program goals, procedures, and outcomes are deemed acceptable by those involved. Historically, the views of autistic individuals on these interventions have been overlooked; instead, researchers have focused on the perspectives of clinicians and parents. This study used a survey with open-ended questions to explore autistic adults’ perspectives on the acceptability of common intervention goals. Our research team, which included both autistic and nonautistic members, analyzed and categorized the survey answers into four themes: “Autistic Way of Being & The Double Empathy Problem”; “Supporting Autonomy, Self-Advocacy, and Interdependence”; “Implementation Matters”; and “Moving Beyond Behavior.” Findings aim to encourage providers to develop intervention goals that align with the perspectives of the autistic community.
Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)
Authors: Weichenhan Dieter , Riedel Anna , Sollier Etienne , Toprak Umut H. , Hey Joschka , Breuer Kersten , Wierzbinska Justyna A. , Touzart Aurore , Lutsik Pavlo , Bähr Marion , Östlund Anders , Nilsson Tina , Jacobsson Susanna , Edler Marcel , Waraky Ahmed , Behrens Yvonne Lisa , Göhring Gudrun , Schlegelberger Brigitte , Steinek Clemens , Harz Hartmann , Leonhardt Heinrich , Dolnik Anna , Reinhardt Dirk , Bullinger Lars , Palmqvist Lars , Lipka Daniel B. , Plass Christoph 
Published: August 2024

Abstract
Acute myeloid leukemia (AML) with the t(7;12)(q36;p13) translocation occurs only in very young children and has a poor clinical outcome. The expected oncofusion between break point partners (motor neuron and pancreas homeobox 1 [MNX1] and ETS variant transcription factor 6 [ETV6]) has only been reported in a subset of cases. However, a universal feature is the strong transcript and protein expression of MNX1, a homeobox transcription factor that is normally not expressed in hematopoietic cells. Here, we map the translocation break points on chromosomes 7 and 12 in affected patients to a region proximal to MNX1 and either introns 1 or 2 of ETV6. The frequency of MNX1 overexpression in pediatric AML is 2.4% and occurs predominantly in t(7;12)(q36;p13) AML. Chromatin interaction assays in a t(7;12)(q36;p13) induced pluripotent stem cell line model unravel an enhancer-hijacking event that explains MNX1 overexpression in hematopoietic cells. Our data suggest that enhancer hijacking may be a more widespread consequence of translocations in which no oncofusion product was identified, including t(1;3) or t(4;12) AML.
Real-world incidence and prevention of tumor lysis syndrome in chronic lymphocytic leukemia treated with venetoclax
Authors: Valtis Yannis K. , Nemirovsky David , Derkach Andriy , Sharan Saumya , Kabel Charlene , Ortiz Ricardo , Thompson Meghan C. , Roeker Lindsey E. , Geyer Mark B. 
Published: August 2024

Abstract
Venetoclax is a B-cell lymphoma 2 inhibitor used in chronic lymphocytic leukemia (CLL), which can cause tumor lysis syndrome (TLS). We aimed to determine the incidence of, and risk factors for, TLS among patients with CLL/small lymphocytic lymphoma who received treatment with venetoclax at our institution from 1 January 2016 to 31 December 2020. We included 616 venetoclax escalations among 136 patients with CLL. Overall, 74 patients (54%) underwent escalation exclusively outpatient, 35 (26%) had at least 1 planned hospitalization, and 27 (20%) were escalated exclusively inpatient. During venetoclax initiation, 86% of patients received allopurinol, 71% intravenous hydration, 18% phosphate binders, and 10% prophylactic rasburicase. Among the entire cohort, 7 patients (5.1%) developed laboratory TLS by modified Cairo Bishop criteria and none developed clinical TLS. Incidence of laboratory TLS was 15% for those escalated exclusively inpatient, 2.9% for those with any prophylactic hospitalization, and 2.7% for those escalated exclusively outpatient. Those who developed TLS were more likely to have higher TLS risk, and no additional risk factors were identified. In this single institution retrospective cohort study, laboratory TLS was observed, although clinical TLS was not. Prophylactic measures, including use of IV hydration, may have contributed to low rates of observed TLS in the outpatient setting.
Electrophysiological effects of Japanese cedarwood on sleep quality in humans
Authors: Okamoto Tsuyoshi , Nakashima Taisuke , Permana Kurniawan Eka , Fadilla Zennifa , Watanabe Yuichiro , Yasunari Shinji , Nagano Jun , Fujimoto Noboru , Shimizu Kuniyoshi 
Published: August 2024

AbstractSleep plays an important role in human health. Changes in the sleeping environment can affect sleep quality. The present study investigated the effects of natural wood on sleep quality. The interior material was a fully used Cryptomeria japonica wood board (Japanese cedar room), while the particleboard and medium-density fiberboard (MDF) were covered by a vinyl cloth with a woodgrain (resin room). In order to assess sleep quality, the sleep–depth index (SDI) is calculated based on the lengths of sleep stage 3 and the rapid eye movement (REM) stage using electroencephalography (EEG). Before the sleep experiments, the Pittsburgh Sleep Quality Inventory (PSQI) and Morningness–Eveningness Questionnaire (MEQ) were administered to confirm the participants’ usual sleep habits. Thirteen participants were invited to sleep in two different environments. The MEQ before sleep experiments confirmed that eight participants were of the intermediate type and five participants were of the moderate evening type. According to the PSQI, three participants were poor sleepers and ten were good sleepers. The sleep EEG demonstrated that 12 of 13 participants had higher SDI in the Japanese cedarwood room than in the resin room. A Wilcoxon signed-rank test revealed that SDI was significantly prolonged in the Japanese cedarwood room than in the resin room, regardless of the small sample size (n = 13, z = 2.48, p = 0.014, effect size = 0.78). The present study demonstrated that the indoor environment with C. japonica induced a significantly higher SDI compared to that with wood-grain vinyl cloth. This indicates that the interior materials of C. Japonica wood can positively influence the sleep environment.
Supporting the right workplace experience: a dynamic evaluation of three activation programmes for young job seekers in Slovakia
Authors: Štefánik Miroslav , Lafférs Lukáš 
Published: August 2024

AbstractThis paper investigates three alternative active labour market policy programmes available to young job seekers in Slovakia who were registered in 2011. All of the programmes facilitate gaining work experience and share a comparable design; however, they differ mainly in the collected workplace experience and the composition of participants. Using administrative data, we first explore the selection into each programme; second, we estimate the treatment effects on job seekers’ postparticipation absence from the registry of the unemployed. For this we argue that we have sufficiently rich data to control for selection into programs. We use a dynamic estimator and report the average treatment effects of participation in different periods between the sixth and fifteenth month after starting unemployment. For participation in earlier stages of unemployment, we confirm differences in the programmes impacts, with patterns described by previous literature; workplace experience collected in either the private sector or in a regular workplace appears to improve the chances of absence from registered unemployment of young job seekers relatively more than does participation in a public works type of programme. When compared later in the unemployment spell, the between-programme differences level out. Despite its ambivalent average impact, the public works type of programme positively impacts specific subgroups of participants.