bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medial Meniscectomy at the Time of ACL Reconstruction Is Associated With Postoperative Anterior Tibial Translation: A Retrospective Analysis
Authors: Fithian Andrew , Manoharan Aditya , Chapek Michael , Xie Virginia , Ghahremani Jacob , Culler Mckenzie , Watarastaporn Tanya , Khan Najeeb 
Published: August 2024

Background: Medial meniscal pathology and management have not been associated with postoperative anterior tibial translation (ATT) after anterior cruciate ligament reconstruction (ACLR). Purpose: The purpose of this study was to evaluate the role of medial meniscal injury and treatment on pre- and postoperative ATT in the setting of primary ACLR. More specifically, the association between repairable medial meniscal tears, medial meniscectomy, and postoperative ATT, along with rates of revision surgery, was examined. Study Design: Cohort study; Level of evidence, 3. Methods: A retrospective review was performed for patients who underwent ACLR between January 1, 2010 and December 31, 2015 at a single center. Descriptive data were obtained from an institutional database for a total of 396 patients included in this study and followed for 1 year postoperatively. Statistical analysis was performed to examine associations of meniscal treatment with postoperative ATT measurements made by KT-1000 arthrometer. Results: A total of 243 patients underwent isolated ACLR with autograft, 72 patients underwent autograft ACLR and partial medial meniscectomy (MMx) (ACLR + MMx), and 81 patients underwent autograft ACLR and medial meniscal repair (MMR) (ACLR + MMR). Patients with ACLR + MMx had higher mean age and body mass index compared with patients in the other groups. Patients who underwent ACLR + MMx had greater postoperative side-to-side ATT compared with patients undergoing ACLR (1.55 mm vs 1.07 mm; P = .04) or patients undergoing ACLR + MMR (1.55 mm vs 1.01 mm; P = .03). The ACLR + MMx group was less likely to have symmetric (<3-mm side-to-side difference) postoperative ATT compared with the ACLR group (85% vs 93%; P = .03). There was no difference in postoperative ATT between ACLR and ACLR + MMR. Postoperative return to the operating room was greater in the ACLR + MRR group compared with the ACLR + MMx group (21.9% vs 8.2%; P = .05). Conclusion: MMx at the time of ACLR led to higher postoperative ATT compared with isolated ACLR or ACLR + MMR.
Paper 26: Role of Age on Survival of Anterior Cruciate Ligament Primary Repair at minimum 5-year follow-up
Authors: Rilk Sebastian , DiFelice Gregory , van der List Jelle , Vermeijden Harmen Daniel , Goodhart Gabriel , O'Brien Robert 
Published: August 2024

Objectives: Short-term follow-up of anterior cruciate ligament (ACL) primary repair (ACLPR) presented increased failure risk (37%) in patients ≤21 years of age (y/o), however low rates in patients >21 y/o (3.5%). Mid- and long-term clinical evidence for contemporary anterior cruciate ligament primary repair (ACLPR) is lacking, whereas outcomes of historical ACL repair were shown to deteriorate at midterm follow-up after initial good short-term outcomes. This study evaluates age-differentiated survival rates of ACLPR at 5-year FU to assess whether the previously presented rates at 2-year FU can be maintained at 5-year FU. Methods: The first 113 consecutive patients with proximal ACL tears undergoing ACLPR by a single surgeon, from 04/2008 to 09/2017, were prospectively followed up. Indication for ACLPR was determined if a proximal type I or II tear and good to excellent tissue quality was present. Failure and re-operation rates, patient reported outcome measurements (PROMs) (IKDC score, Lysholm score, Forgotten Joint score, ACL-RSI score, and Tegner Activity Scale Difference) and instrumented anterior-tibial translation side-to-side difference (ATT-SSD) were recorded at minimum 5-year FU. Results: A total of 96 patients (85%) with a mean final FU of 7.2 ±2.3 (5.0 – 12.8) years were evaluated. Ipsilateral reinjury rates for patients ≤21 y/o, from 2- to 5-year FU, remained stable (40.0%) with no additional failure recorded. Six additional re-injuries were detected in patients >21 y/o, leading to a failure rate of 9.8% at 5-year FU. Mean time to failure following surgery was 17 ±11 months in patients ≤21 y/o versus 26 ±16 months in patients >21 y/o. Re-operation rates for patients ≤21- and >21 y/o were 0.0% and 4.0% respectively. PROMs showed no significant differences as compared to outcomes at 2-year FU (p <.001) and 5-year ATT-SSD was 0.75 ±1.2 mm. Conclusions: ACLPR is correlated with a high risk of early failure (40.0% at 17 ±11 months) in patients < 21 y/o, however no additional subsequent re-injuries were reported at minimum final 5-year FU. In contrast, patients >21 y/o demonstrate low failure rates at 2- (3.5%) and 5-year FU (9.8%).
Paper 37: Outcomes of Medial Patellofemoral Ligament Reconstruction Patients Over 30 Years of Age
Authors: Magnussen Robert , Cavendish Parker , Milliron Eric , Heyniger John , Barker Tyler , Flanigan David 
Published: August 2024

Objectives: Medial patellofemoral ligament reconstruction (MPFLR) is a common procedure to treat recurrent patellofemoral instability, typically in a younger, active patient population. While many patients treated with MPFLR fall into this age group, patellar instability is encountered in older patients as well. Outcomes in older patient populations have been less frequently reported in the literature. We hypothesize that patients over 30 at the time of surgery will have poorer postoperative patient reported outcome measures (PROMs) following MPFLR than patients under age 30. Methods: Retrospective review was undertaken to identify patients who underwent isolated MPFLR between 2008 and 2020. Chart review was utilized to obtain patient demographic, anatomical, and surgical factors. Patients were contacted via mail and/or phone and patient-reported outcomes were recorded. PROMs included the knee injury and osteoarthritis injury outcome score (KOOS), Norwich patellar instability score, and Marx activity score. Differences between groups were evaluated by Mann-Whitney and Fisher-exact tests. KOOS and Norwich scores were also evaluated using a multivariable linear regression adjusting for the following variables selected a priori: sex, body mass index, Caton-Deschamps index, TT-TG distance, sulcus angle, and the presence or absence of ≥ Grade 2 cartilage damage. Results: A total of 228 patients underwent isolated MPFL reconstruction in the study period. 177 patients (78%) had data on repeat patellar dislocations at least 1 year postoperatively, with a median follow-up interval of 40.8 months (3.4 years) postoperative. Of these 177, 140 were under age 30 at time of surgery, 7 (5%) of whom had a repeat dislocation; of 37 patients at or over age 30 at time of surgery, 2 (6.6%) had a repeat dislocation. 147 patients further completed KOOS, Norwich, and Marx activity score surveys with a median follow-up of 45.3 months (3.8 years) post-operative. Patients ≥ 30 years old at surgery (n=31) had lower KOOS pain (82.1 vs 91.7; p=0.03), KOOS activities of daily living (94.1 vs 97.1; p=0.04), and Marx activity scores (1 vs 7; p<0.001) compared to the patients under age 30 (n=116) (Table 1). After adjusting for covariates, multivariable regression models for KOOS and Norwich scores showed only KOOS pain subscores were lower for patients ≥ 30 years (β= -4.2; 95% CI -8.3, -0.2; p=0.04). Conclusions: Patients over age 30 at the time of MPFLR demonstrated similar recurrence risk but lower KOOS pain and Marx activity scores at 3.8 years postoperative than patients under age 30 at the time of MPFLR. [Figure: see text]
Poster 130: Incidence and Treatment Characteristics of Coracoclavicular Ligament Injuries with Associated Lateral Clavicle Fractures in a Military Population
Authors: Panarello Nicholas , O'Hara Matthew , Feeley Scott , Colantonio Donald , Harrington Colin , Dickens Jonathan , Kilcoyne Kelly 
Published: August 2024

Objectives: To identify the demographics and characteristics of lateral clavicle fractures treated with coracoclavicular ligament repair or reconstruction, as well as to the subsequent postoperative complications. Methods: The United States Military Health System Data Repository was queried for patients with a Current Procedural Terminology (CPT) code for coracoclavicular ligament reconstruction between October 2013 and March 2020. Radiographs were evaluated for the presence of a lateral clavicle fracture at the time of initial injury and classified based on the modified Neer classification. The electronic health records to include operative reports and clinical notes were then reviewed for patient demographics, operative technique, and clinical course. Results: A total of 965 patients underwent coracoclavicular ligament repair or reconstruction between October 2013 and March 2020. Forty patients (4.6%) were identified with concomitant lateral clavicle fractures. The mean age of 29.575 years (SD 10.1) of which 85% male and 80% were active duty. Based on the Neer classification, there were three type I, 18 type IIB, 12 type III, and seven type V. Twenty-two of these injuries were addressed acutely (55%), while 18 were managed chronically (45%). Open reduction internal fixation of the distal clavicle was performed in 16 of the 40 patients (40%). An equivalent distribution of concomitant coracoclavicular ligament repair versus reconstruction was performed amongst the forty total patients. Postoperatively, two patients went on to nonunion and seven patients had loss of coracoclavicular reduction. Five patients returned to the operating room for removal of symptomatic hardware (3), revision (1), and irrigation and debridement (1). At the conclusion of their fracture care, five (12.5%) of patients necessitated medical separation from the military. Conclusions: A small subset of coracoclavicular reconstructions performed in the military occur for a concomitant lateral clavicle fracture. The majority of military patients who underwent coracoclavicular ligament repair or reconstruction in the setting of a lateral clavicle regained full, pain-free range of motion. Although malunion and nonunion are known complications of this injury pattern, only two patients went on to develop these complications. However, postoperative complications were common, occurring in 25% of patients. At the conclusion of their fracture care, five (12.5%) of patients necessitated medical separation from the military.
Poster 201: Comparison of Short-Term Patient-Reported Outcomes Between Patients Undergoing Hip Arthroscopy With Versus Without a Perineal Post
Authors: Fasulo Sydney , Marder Ryan , Kraeutler Matthew , Castrodad Iciar Davila , Mei-Dan Omer , Scillia Anthony 
Published: August 2024

Objectives: Previous studies have demonstrated rates of groin-related nerve and/or soft-tissue complications as high as 46% following hip arthroscopy; however, the recent use of a postless hip distraction setup has shown promising reductions in these complications. A recent prospective study compared postoperative complications of patients undergoing hip arthroscopy with and without the use of a perineal post, with significantly fewer complications among patients undergoing postless hip arthroscopy. The purpose of this study was to prospectively compare the short-term clinical outcomes of patients undergoing hip arthroscopy with versus without the use of a perineal post. Methods: A prospective, single-surgeon cohort study was performed on all patients undergoing hip arthroscopy between January 2020 and March 2022. A post-free hip distraction system was used at one center at which the senior author operates, and a setup with a perineal post was used at another surgical location. An electronic survey of patient-reported outcome measures (PROMs) was completed by each patient at a minimum of 1 year postoperatively. PROMs included a visual analog scale (VAS) for pain, University of California Los Angeles (UCLA) Activity Scale, modified Harris Hip Score (mHHS), Hip Outcome Score-Sport (HOS-Sport), and a Single Assessment Numeric Evaluation (SANE). Results: Sixty patients were reached for follow-up (35 post, 25 patients postless). No differences were found between the post and postless groups in terms of age at surgery (34 ± 13 vs 30 ± 11 years, p = 0.18), sex (60% vs 56% female patients, p = 0.76), body mass index (26 ± 7 vs 24 ± 4, p = 0.25), or follow-up duration (23.5 ± 8 vs 20.8 ± 10 months, p = 0.25). There was a significantly higher VAS for pain (3.0 ± 2.6 vs 1.6 ± 1.6, p = 0.03) and lower UCLA Activity Score (6.9 ± 2.5 vs 8.2 ± 2.1, p = 0.04) in the post-assisted group. There were no significant differences between groups in other PROMs including mHHS (73.4 ± 16.7 vs 81.0 ± 12.5, p = 0.07), HOS-Sport (72.4 ± 26.1 vs 82.1 ± 25.8, p = 0.18), or SANE (78.6 ± 25.2 vs 87.6 ± 12.2, p = 0.13). Conclusions: Postless hip arthroscopy may result in an extended reduction in pain and perhaps higher activity levels compared to traditional post-assisted hip arthroscopy. Larger studies are warranted to corroborate these findings.
Poster 360: Long-Leg Lateral Monopodal Stress Radiographs for the Assessment of Anterior Tibial Translation with Anterior Cruciate Ligament Injury: A Prospective Study
Authors: Otremba Jace , Tollefson Luke , Knowlan Claire , Kennedy Nicholas , LaPrade Robert 
Published: August 2024

Objectives: The purpose of this study is to use standing anterior cruciate ligament (ACL) stress radiographs to evaluate how posterior tibial slope (PTS) compared to anterior tibial translation (ATT) in an injured knee. A secondary purpose was to determine how posterior tibial slope (PTS) affects ATT side-to-side difference. Our hypothesis was that anterior tibial translation would be higher in the injured knee compared to the contralateral side and posterior tibial slope will have a positive effect on anterior tibial translation. Methods: A retrospective study of ACL stress radiographs was assessed from patients with primary ACL reconstructions with no concomitant ligamentous injury between January 2023 and August 2023. Institutional Review Board approval was obtained. The bilateral radiographs were long-leg lateral “stress views” which was accomplished by monopodal weight-bearing in 20° flexion and are a part of the initial patient workup. Stress radiographs were utilized to measure the anterior tibial translation (ATT) and posterior tibial slope (PTS) for both knees. Differences in ATT between knees and the correlation between PTS and ATT was assessed via paired t-tests and regression analysis. Results: A final cohort of 39 patients were analyzed using preoperative ACL stress radiographs. The results reported a significant regression with positive correlation between posterior tibial slope (PTS) and anterior tibial translation for the injured knee using both anatomic (Figure 1, P<0.001, R2=0.302) and mechanical (Figure 2, P=0.038, R2=0.111) PTS measurements. Anatomic PTS measurements are better at predicting ATT for the injured knee compared to mechanical PTS measurements. Conclusions: The findings of this study report a significant regression with a positive correlation between posterior tibial slope (PTS) and anterior tibial translation (ATT) of the injured knee, with anatomic PTS measurements being a better predictor of ATT than mechanical PTS measurements. This indicates an important relationship between PTS and ATT with higher PTRS predicting higher ATT.
Transcriptomic profiling reveals histone acetylation-regulated genes involved in somatic embryogenesis in Arabidopsis thaliana
Authors: Wójcikowska Barbara , Chwiałkowska Karolina , Nowak Katarzyna , Citerne Sylvie , Morończyk Joanna , Wójcik Anna Maria , Kiwior-Wesołowska Agnieszka , Francikowski Jacek , Kwaśniewski Mirosław , Gaj Małgorzata Danuta 
Published: August 2024

Abstract
Background
Somatic embryogenesis (SE) exemplifies the unique developmental plasticity of plant cells. The regulatory processes, including epigenetic modifications controlling embryogenic reprogramming of cell transcriptome, have just started to be revealed.

Results
To identify the genes of histone acetylation-regulated expression in SE, we analyzed global transcriptomes of Arabidopsis explants undergoing embryogenic induction in response to treatment with histone deacetylase inhibitor, trichostatin A (TSA). The TSA-induced and auxin (2,4-dichlorophenoxyacetic acid; 2,4-D)-induced transcriptomes were compared. RNA-seq results revealed the similarities of the TSA- and auxin-induced transcriptomic responses that involve extensive deregulation, mostly repression, of the majority of genes. Within the differentially expressed genes (DEGs), we identified the master regulators (transcription factors - TFs) of SE, genes involved in biosynthesis, signaling, and polar transport of auxin and NITRILASE-encoding genes of the function in indole-3-acetic acid (IAA) biosynthesis. TSA-upregulated TF genes of essential functions in auxin-induced SE, included LEC1/LEC2, FUS3, AGL15, MYB118, PHB, PHV, PLTs, and WUS/WOXs. The TSA-induced transcriptome revealed also extensive upregulation of stress-related genes, including those related to stress hormone biosynthesis. In line with transcriptomic data, TSA-induced explants accumulated salicylic acid (SA) and abscisic acid (ABA), suggesting the role of histone acetylation (Hac) in regulating stress hormone-related responses during SE induction. Since mostly the adaxial side of cotyledon explant contributes to SE induction, we also identified organ polarity-related genes responding to TSA treatment, including AIL7/PLT7, RGE1, LBD18, 40, HB32, CBF1, and ULT2. Analysis of the relevant mutants supported the role of polarity-related genes in SE induction.

Conclusion
The study results provide a step forward in deciphering the epigenetic network controlling embryogenic transition in somatic cells of plants.
Precise partial root-zone irrigation technique and potassium-zinc fertigation management improve maize physio-biochemical responses, yield, and water use in arid climate
Authors: Elshamly Ayman M. S. , Abaza A. S. 
Published: August 2024

Abstract
Background
To optimize irrigation water use and productivity, understanding the interactions between plants, irrigation techniques, and fertilization practices is crucial. Therefore, the experiment aims to assess the effectiveness of two application methods of potassium humate combined with chelated zinc under partial root-zone drip irrigation techniques on maize nutrient uptake, yield, and irrigation water use efficiency across two irrigation levels.

Methods
Open-field experiments were carried out in two summer seasons of 2021 and 2022 under alternate and fixed partial root-zone drip irrigation techniques to investigate their impacts at two irrigation levels and applied foliar and soil applications of potassium humate or chelated zinc in a sole and combinations on maize.

Results
Deficit irrigation significantly increased hydrogen peroxide levels and decreased proline, antioxidant enzymes, carbohydrate, chlorophyll (a + b), and nutrient uptake in both partial root-zone techniques. The implementation of combined soil application of potassium humate and chelated zinc under drought conditions on maize led to varying impacts on antioxidant enzymes and nutritional status, depending on the type of partial root-zone technique. Meanwhile, the results showed that fixed partial root-zone irrigation diminished the negative effects of drought stress by enhancing phosphorus uptake (53.8%), potassium uptake (59.2%), proline (74.4%) and catalase (75%); compared to the control. These enhancements may contribute to improving the defense system of maize plants in such conditions. On the other hand, the same previous treatments under alternate partial root zone modified the defense mechanism of plants and improved the contents of peroxidase, superoxide dismutase, and the uptake of magnesium, zinc, and iron by 81.3%, 82.3%, 85.1%, 56.9%, and 80.2%, respectively.

Conclusions
Adopting 75% of the irrigation requirements and treating maize plants with the soil application of 3 g l−1 potassium humate combined with 1.25 kg ha−1 chelated zinc under alternate partial root-zone technique, resulted in the maximum root length, leaf water content, chlorophyll content, yield, and irrigation water use efficiency.
Decoding IBS: a machine learning approach to psychological distress and gut-brain interaction
Authors: Lundervold Astri J. , Billing Julie E. , Berentsen Birgitte , Lied Gülen A. , Steinsvik Elisabeth K. , Hausken Trygve , Lundervold Arvid 
Published: August 2024

Abstract
Purpose
Irritable bowel syndrome (IBS) is a diagnosis defined by gastrointestinal (GI) symptoms like abdominal pain and changes associated with defecation. The condition is classified as a disorder of the gut-brain interaction (DGBI), and patients with IBS commonly experience psychological distress. The present study focuses on this distress, defined from reports of fatigue, anxiety, depression, sleep disturbances, and performance on cognitive tests. The aim was to investigate the joint contribution of these features of psychological distress in predicting IBS versus healthy controls (HCs) and to disentangle clinically meaningful subgroups of IBS patients.

Methods
IBS patients ($$n = 49$$

n
=
49

) and HCs ($$n = 28$$

n
=
28

) completed the Chalder Fatigue Scale (CFQ), the Hamilton Anxiety and Depression Scale (HADS), and the Bergen Insomnia Scale (BIS), and performed tests of memory function and attention from the Repeatable Battery Assessing Neuropsychological Symptoms (RBANS). An initial exploratory data analysis was followed by supervised () and unsupervised () classification procedures.

Results
The explorative data analysis showed that the group of IBS patients obtained significantly more severe scores than HCs on all included measures, with the strongest pairwise correlation between fatigue and a quality measure of sleep disturbances. The supervised classification model correctly predicted belongings to the IBS group in 80% of the cases in a test set of unseen data. Two methods for calculating feature importance in the test set gave mental and physical fatigue and anxiety the strongest weights. An unsupervised procedure with $$K = 3$$

K
=
3

showed that one cluster contained 24% of the patients and all but two HCs. In the two other clusters, their IBS members were overall more impaired, with the following differences. One of the two clusters showed more severe cognitive problems and anxiety symptoms than the other, which experienced more severe problems related to the quality of sleep and fatigue. The three clusters were not different on a severity measure of IBS and age.

Conclusion
The results showed that psychological distress is an integral component of IBS symptomatology. The study should inspire future longitudinal studies to further dissect clinical patterns of IBS to improve the assessment and personalized treatment for this and other patient groups defined as disorders of the gut-brain interaction. The project is registered at https://classic.clinicaltrials.gov/ct2/show/NCT04296552 20/05/2019.