bluuebunny/crossref_metadata_2025_split huggingface dataset:
PE‐CVD of Hydrophilic‐COOH Functionalized Coatings on Electrolyte Gated Field‐Effect Transistor Electronic Layers
Authors: Magliulo Maria , Pistillo Bianca Rita , Mulla Mohammad Yusuf , Cotrone Serafina , Ditaranto Nicoletta , Cioffi Nicola , Favia Pietro , Torsi Luisa 
Published: September 2012

AbstractA plasma deposition (PE‐CVD) process is proposed to functionalize the surface of P3HT organic semiconductor with an hydrophilic coating characterized by carboxyl groups. The functionalized P3HT is employed as electronic active layer in an electrolyte gated organic field‐effect transistor (EGOFET). Nanometric coatings were plasma deposited at the surface of P3HT from glow discharges fed with ethylene and acrylic acid vapors. The surface chemical composition of coated P3HT along with its wettability, have been assessed by means of X‐ray photoelectron spectroscopy and water contact angle. Results show that PE‐CVD is a valid approach to functionalize P3HT surfaces with carboxyl groups, leaving negligible adverse effect on the EGOFET performances. Possibly, chemical or biological species could be immobilized on PE‐CVD‐functionalized EGOFETs, opening to further developments in their use as sensors. magnified image
Nasal and bronchial airway epithelial cell mediator release in children
Authors: Pringle Emily J. , Richardson Helen B. , Miller David , Cornish Daniella S. , Devereux Graham S. , Walsh Garry M. , Turner Steve W. 
Published: September 2012

AbstractObjectiveThe present study was designed to test the hypothesis that airway epithelial cell (AEC) mediator release is similar in upper and lower airway AEC in children.MethodsNasal and bronchial AEC were collected by brushings from children scheduled for general anesthetic. AEC release of the following mediators was measured: interleukin (IL)‐6, IL‐8, Granulocyte Colony Stimulating Factor (G‐CSF), regulated on activation, normal T‐cell expressed and secreted (RANTES), monocyte chemoattractant protein‐1 (MCP‐1), vascular endothelial growth factor (VEGF), matrix metallo proteinase (MMP)‐9, and tissue inhibitor of metalloproteinases (TIMP)‐1.ResultsAEC were cultured in 34 children, mean age 7.3 years. Release of IL‐6, IL‐8, and G‐CSF was significantly higher in nasal compared with bronchial AEC but nasal and bronchial AEC release of other mediators was not significantly different. Treatment of AEC with IL‐1 β and tumor necrosis factor‐α increased secretion of all mediators. Release of IL‐6 and GSCF remained higher in nasal AEC compared with bronchial AEC following stimulation.ConclusionsIn epidemiological studies, nasal AEC may be a useful surrogate for bronchial AEC for the study of RANTES, MCP‐1, TIMP‐1, and MMP‐9 release in children but bronchial AEC will remain the gold standard. Pediatr Pulmonol. 2012; 47:1215–1225. © 2012 Wiley Periodicals, Inc.
Identification of Cys255 in HIF‐1α as a novel site for development of covalent inhibitors of HIF‐1α/ARNT PasB domain protein–protein interaction
Authors: Cardoso Rosa , Love Robert , Nilsson Carol L. , Bergqvist Simon , Nowlin Dawn , Yan Jiangli , Liu Kevin K.‐C. , Zhu Jing , Chen Ping , Deng Ya‐Li , Dyson H. Jane , Greig Michael J. , Brooun Alexei 
Published: October 2012

AbstractThe heterodimer HIF‐1α (hypoxia inducible factor)/HIF‐β (also known as ARNT‐aryl hydrocarbon nuclear translocator) is a key mediator of cellular response to hypoxia. The interaction between these monomer units can be modified by the action of small molecules in the binding interface between their C‐terminal heterodimerization (PasB) domains. Taking advantage of the presence of several cysteine residues located in the allosteric cavity of HIF‐1α PasB domain, we applied a cysteine‐based reactomics “hotspot identification” strategy to locate regions of HIF‐1α PasB domain critical for its interaction with ARNT. COMPOUND 5 was identified using a mass spectrometry‐based primary screening strategy and was shown to react specifically with Cys255 of the HIF‐1α PasB domain. Biophysical characterization of the interaction between PasB domains of HIF‐1α and ARNT revealed that covalent binding of COMPOUND 5 to Cys255 reduced binding affinity between HIF‐1α and ARNT PasB domains approximately 10‐fold. Detailed NMR structural analysis of HIF‐1α‐PasB‐COMPOUND 5 conjugate showed significant local conformation changes in the HIF‐1α associated with key residues involved in the HIF‐1α/ARNT PasB domain interaction as revealed by the crystal structure of the HIF‐1α/ARNT PasB heterodimer. Our screening strategy could be applied to other targets to identify pockets surrounding reactive cysteines suitable for development of small molecule modulators of protein function.
High‐resolution isotope‐dilution mass spectrometry using metabolism of isotope‐labeled compounds: Application to drug metabolites
Authors: Vrbanac J. James , Hilgers Allen , Dubnicka Tyson , Shilliday F. Barclay , Humphries David , Hayes Roger N. 
Published: September 2012

RATIONALEHerein we describe a generic quantitative method using high‐resolution, isotope‐dilution (HRID) metabolism of isotope‐labeled compounds and apply it to the analysis of drug metabolites (DMs) in human plasma. Metabolites (drug) in Safety Testing (MIST) application was one goal.METHODSTestosterone (T) and diclofenac (D) were chosen for mass defect characteristics. T, [14C]T, [13C3]T, D, [14C]D, and [13C6]D were metabolized separately in vitro to produce test metabolites. Liquid chromatography/radioactivity monitoring (LC/RAM) analysis was used to determine the concentration of the test metabolites in the incubates. The incubates containing 6β‐hydroxy‐T (6βHT), [13C3]6βHT, 4′‐hydroxy‐D (4′HD) and [13C6]4′HD were used to make standard curves. Plasma samples were prepared by 'dilute‐and‐shoot' and analyzed by LC/MS using SCIEX 5000 and Thermo Orbitrap instrumentation.RESULTSHuman hepatic microsomes and the S9 fraction produced between 2–6 μM β‐hydroxy‐T and 4′‐hydroxy‐D at 60 min starting with 10 μM parent drug as determined by LC/RAM. It was assumed that the amounts of [13C3]6βHT and [13C6]4′HD produced were similar. Dilutions and standard curves were prepared in human plasma. Analysis of the DMs by LC/MS/MS and LC/HRMS exhibited linear responses over a useable range.CONCLUSIONSHRID with metabolism of an isotope‐labeled compound reduces the number of analytical variables considerably. Metabolism of the parent drug to DMs represents a simpler alternative quantitative method compared with traditional approaches. The method will have useful applications for evaluating MIST situations. Copyright © 2012 John Wiley & Sons, Ltd.
Digital evidence collection for web image access
Authors: Hsieh Che‐Jen , Li Jung‐Shian , Liu Wei‐Cheng 
Published: September 2012

ABSTRACTAs the volume of multimedia data exchanged over the Internet continues to grow, the problem of preventing the unauthorized duplication of copyright‐protected images or the dissemination of undesirable material such as pornographic pictures has become increasingly important. The majority of the images circulated over the Internet are coded in the JPEG format. Thus, the present study proposes a novel digital feature retrieval scheme designed to detect unlawful dissemination of pre‐selected JPEG images. In the proposed approach, the packet‐level features of the target JPEG image are collected in advance and are stored in a feature database. Thereafter, the features of all the packets passing through a nominated router are compared on‐the‐fly with those in the feature database in order to detect any transmissions of the target images. The experimental results show that the proposed packet‐level forensic scheme is far more efficient than existing application‐level schemes. As a result, the proposed scheme provides a viable solution for the background monitoring of JPEG streams over large‐scale network environments such as the Internet in order to detect unlawful transmissions and to compile digital evidence of such transmissions for possible future legal proceedings. Copyright © 2012 John Wiley & Sons, Ltd.
Attribute‐based ring signcryption scheme
Authors: Guo Zhenzhou , Li Mingchu , Fan Xinxin 
Published: September 2012

ABSTRACTIn this paper, we present attribute‐based ring signcryption scheme, which realizes the concept of ring signcryption in the attribute‐based encryption frame firstly. In our system, it allows a user to signcrypt a message by a set of attributes that are chosen without revealing its identity. In additional, we propose the security models and prove the confidentiality and unforgeability of our schemes. We also present the efficiency of our scheme by comparisons. Copyright © 2012 John Wiley & Sons, Ltd.
A practical secure and efficient enterprise digital rights management mechanism suitable for mobile environment
Authors: Chang Chin‐Chen , Chang Shih‐Chang , Yang Jen‐Ho 
Published: September 2012

ABSTRACTDigital rights management (DRM) is a term for access control technologies that are used by hardware manufacturers, publishers, copyright holders, and individuals to limit the use of digital content and devices. Enterprise digital rights management (E‐DRM) is the application of DRM technology to prevent illegal users from accessing the confidential data of an enterprise. In 2010, Chang et al. proposed an efficient E‐DRM scheme to solve the flaws of Chen's scheme. However, we still found some weaknesses in their scheme. In this article, we propose an improved secure and efficient E‐DRM mechanism based on a one‐way hash function and exclusive‐or. Our mechanism overcomes the weaknesses in the scheme of Chang et al. and also reduces computation costs. In addition, we used BAN logic to show the correctness of our mechanism. Copyright © 2012 John Wiley & Sons, Ltd.
Carbon Nanotubes as Plant Growth Regulators: Effects on Tomato Growth, Reproductive System, and Soil Microbial Community
Authors: Khodakovskaya Mariya V. , Kim Bong‐Soo , Kim Jong Nam , Alimohammadi Mohammad , Dervishi Enkeleda , Mustafa Thikra , Cernigla Carl E. 
Published: September 2012

AbstractMulti‐walled carbon nanotubes (CNTs) can affect plant phenotype and the composition of soil microbiota. Tomato plants grown in soil supplemented with CNTs produce two times more flowers and fruit compared to plants grown in control soil. The effect of carbon nanotubes on microbial community of CNT‐treated soil is determined by denaturing gradient gel electrophoresis and pyrosequencing analysis. Phylogenetic analysis indicates that Proteobacteria and Bacteroidetes are the most dominant groups in the microbial community of soil. The relative abundances of Bacteroidetes and Firmicutes are found to increase, whereas Proteobacteria and Verrucomicorbia decrease with increasing concentration of CNTs. The results of comparing diversity indices and species level phylotypes (OTUs) between samples showed that there is not a significant affect on bacterial diversity.
Emerging In Vitro Models for Safety Screening of High‐Volume Production Nanomaterials under Environmentally Relevant Exposure Conditions
Authors: Kathawala Mustafa Hussain , Xiong Sijing , Richards Mark , Ng Kee Woei , George Saji , Loo Say Chye Joachim 
Published: September 2012

AbstractThe rising production of nanomaterial‐based consumer products has raised safety concerns. Testing these with animal and other direct models is neither ethically nor economically viable, nor quick enough. This review aims to discuss the strength of in vitro testing, including the use of 2D and 3D cultures, stem cells, and tissue constructs, etc., which would give fast and repeatable answers of a highly specific nature, while remaining relevant to in vivo outcomes. These results can then be combined and the overall toxicity predicted with relative accuracy. Such in vitro models can screen potentially toxic nanomaterials which, if required, can undergo further stringent studies in animals. The cyto‐ and phototoxicity of some high‐volume production nanomaterials, using in vitro models, is also reviewed.
An environment for modeling and simulation of message‐passing parallel applications for cloud computing
Authors: Garg Saurabh Kumar , Buyya Rajkumar 
Published: September 2012

SUMMARYAs Cloud computing is becoming a mainstream platform, it has also become important to understand the implications on customers' applications or systems when deployed on Clouds. Therefore, simulation tools become a critical requirement that not only evaluate the performance of Clouds but also help in developing Cloud computing further. However, current simulation solutions for Clouds do not support many important application paradigms such as message‐passing parallel applications. This limits the usage of these solutions to study the deployment of many scientific applications on Clouds. In this paper, after recognizing the needs and requirements of the Cloud research and development community, we propose a Cloud simulation environment with a scalable network and message‐passing application model that allows accurate evaluation of scheduling and resource provisioning policies and thus helps in optimizing the performance of a Cloud infrastructure. Copyright © 2012 John Wiley & Sons, Ltd.
Eisenbahnüberführung Simmerbach
Authors: Feldmann Markus , Pak Daniel , Kopp Maik , Schillo Nicole , Wirth Tobias , Seidl Günter , Mensinger Martin , Koch Eckart 
Published: October 2012

AbstractDie VFT‐Rail Pilotbrücke über den Simmerbach wird im Rahmen einer Bauartzulassung durch Feldmessungen überwacht. Die Überwachung umfasst sowohl statische Zuglasten als auch Überfahrten eines Messzuges wie auch des Regelverkehrs. Ein Schwerpunkt der Messungen sind die direkt auf dem Überbau angeordneten Schienenstützpunkte, insbesondere beim Übergang zum Schotterbett am Brückenende. Das Bemessungsverfahren der Verbunddübel der externen Bewehrung des Brückensystems wird anhand von gemessenen Nennspannungen der Stahlprofile überprüft und bewertet.Railway bridge Simmerbach – Monitoring of the composite dowels and the rail fasteners in the VFT‐Rail system. A monitoring system is installed at the VFT‐Rail pilot bridge over the Simmerbach Valley within the scope of the licensing procedure. It surveys static train loads and dynamic crossings of a test train and of the regular train loads. The focus of the monitoring is set on the rail fastening system of the non‐ballast superstructure near the transition to the normal ballast track. The design concept of the composite dowels implemented in the external reinforcement of the bridge is assessed by measuring the nominal stresses in the steel sections.
Iterative receiver for amplify‐and‐forward relay networks with unknown noise correlation
Authors: Zhang Chao , Tang Suhua , Ren Pinyi 
Published: September 2012

ABSTRACTFor amplify‐and‐forward relay networks, we propose an iterative scheme to estimate channel and detect information symbols for the multi‐antenna destination in spatially correlated noise. The equivalent channel coefficients and noise covariance are estimated by expectation–maximization algorithm. In addition, we discuss the initialization of iteration and analyze the modified Cramér–Rao bound to show the performance of the proposed iterative estimation. Moreover, on the basis of the structure of the proposed iterative estimator, a joint channel estimation and detection receiver is also provided. Finally, simulation results show that the proposed channel estimator and receiver can achieve the optimal performances in amplify‐and‐forward relay networks with unknown noise correlation. Copyright © 2012 John Wiley & Sons, Ltd.
Fly motion vision: from optic flow to visual course control
Authors: Borst A. 
Published: September 2012

Abstract
Optic flow-based navigation has been stud­ied extensively in flies, both in tethered as well as in freely flying animals. As neural con­trol elements, the tangential cells of the lobu­la plate seem to play a key role: they are sen­sitive to visual motion, have large receptive fields, and, with their spatial distribution of preferred directions, match the optic flow as elicited during certain types of flight maneu­vers. However, the neural circuit presynaptic to the tangential cells responsible for extract­ing the direction of motion locally has long escaped investigation, due to the small size of the participating neurons. Recent prog­ress was made here by combining genetic si­lencing of candidate neurons with whole-cell patch recording from tangential cells in Dro­sophila. This approach led to the identifica­tion of lamina neurons L1 and L2 providing the input signals to two parallel motion de­tection circuits, specialized for brightness in­crements (L1, ON-pathway) and decrements (L2, OFF-pathway), respectively.
Parenting processes and aggression: The role of self‐control among Turkish adolescents
Authors: Özdemir Yalçın , Vazsonyi Alexander T. , Çok Figen 
Published: October 2012

ABSTRACTThe present study examined the direct and indirect relationships between parenting processes (parental closeness, parental monitoring, and parental peer approval), low self‐control, and aggression. Participants were 546 adolescents aged 14–18 attending state high schools in Turkey. Participants completed a questionnaire that included measures of parenting processes, self‐control, and aggression. Findings provided evidence of both direct and indirect effects of maternal and paternal parenting processes on aggression through low self‐control. Specifically, results showed that maternal closeness, paternal peer approval and both maternal and paternal monitoring were positively and directly related to low self‐control, and indirectly related to aggression through low self‐control. Together, parenting processes and low self‐control explained 21% of the variance in aggression. Implications for self‐control theory and directions for future research are discussed.
Spontaneous formation of travelling localized structures and their asymptotic behaviour in binary fluid convection
Authors: Watanabe Takeshi , Iima Makoto , Nishiura Yasumasa 
Published: September 2012

AbstractWe study spontaneous pattern formation and its asymptotic behaviour in binary fluid flow driven by a temperature gradient. When the conductive state is unstable and the size of the domain is large enough, finitely many spatially localized time-periodic travelling pulses (PTPs), each containing a certain number of convection cells, are generated spontaneously in the conductive state and are finally arranged at non-uniform intervals while moving in the same direction. We found that the role of PTP solutions and their strong interactions (collision) are important in characterizing the asymptotic state. Detailed investigations of pulse–pulse interactions showed the differences in asymptotic behaviour between that in a finite but large domain and in an infinite domain.
Ageostrophic instability in rotating shallow water
Authors: Wang Peng , McWilliams James C. , Kizner Ziv 
Published: September 2012

AbstractLinear instabilities, both momentum-balanced and unbalanced, in several different $ \overline{u} (y)$ shear profiles are investigated in the rotating shallow water equations. The unbalanced instabilities are strongly ageostrophic and involve inertia–gravity wave motions, occurring only for finite Rossby ($\mathit{Ro}$) and Froude ($\mathit{Fr}$) numbers. They serve as a possible route for the breakdown of balance in a rotating shallow water system, which leads the energy to cascade towards small scales. Unlike previous work, this paper focuses on general shear flows with non-uniform potential vorticity, and without side or equatorial boundaries or vanishing layer depth (frontal outcropping). As well as classical shear instability among balanced shear wave modes (i.e. B–B type), two types of ageostrophic instability (B–G and G–G) are found. The B–G instability has attributes of both a balanced shear wave mode and an inertia–gravity wave mode. The G–G instability occurs as a sharp resonance between two inertia–gravity wave modes. The criterion for the occurrence of the ageostrophic instability is associated with the second stability condition of Ripa (1983), which requires a sufficiently large local Froude number. When $\mathit{Ro}$ and especially $\mathit{Fr}$ increase, the balanced instability is suppressed, while the ageostrophic instabilities are enhanced. The profile of the mean flow also affects the strength of the balanced and ageostrophic instabilities.
Mini Nutritional Assessment predicts gait status and mortality 6 months after hip fracture
Authors: Gumieiro David N. , Rafacho Bruna P. M. , Gonçalves Andrea F. , Tanni Suzana E. , Azevedo Paula S. , Sakane Daniel T. , Carneiro Carlos A. S. , Gaspardo David , Zornoff Leonardo A. M. , Pereira Gilberto J. C. , Paiva Sergio A. R. , Minicucci Marcos F. 
Published: September 2012

The aim of the present study was to evaluate the Mini Nutritional Assessment (MNA), the Nutritional Risk Screening (NRS) 2002 and the American Society of Anesthesiologists Physical Status Score (ASA) as predictors of gait status and mortality 6 months after hip fracture. A total of eighty-eight consecutive patients over the age of 65 years with hip fracture admitted to an orthopaedic unit were prospectively evaluated. Within the first 72 h of admission, each patient's characteristics were recorded, and the MNA, the NRS 2002 and the ASA were performed. Gait status and mortality were evaluated 6 months after hip fracture. Of the total patients, two were excluded because of pathological fractures. The remaining eighty-six patients (aged 80·2 (sd 7·3) years) were studied. Among these patients 76·7 % were female, 69·8 % walked with or without support and 12·8 % died 6 months after the fracture. In a multivariate analysis, only the MNA was associated with gait status 6 months after hip fracture (OR 0·773, 95 % CI 0·663, 0·901; P= 0·001). In the Cox regression model, only the MNA was associated with mortality 6 months after hip fracture (hazard ratio 0·869, 95 % CI 0·757, 0·998; P= 0·04). In conclusion, the MNA best predicts gait status and mortality 6 months after hip fracture. These results suggest that the MNA should be included in the clinical stratification of patients with hip fracture to identify and treat malnutrition in order to improve the outcomes.