bluuebunny/crossref_metadata_2025_split huggingface dataset:
IL36RN mutation causing generalized pustular psoriasis in a Palestinian patient
Authors: Renert‐Yuval Yael , Horev Liran , Babay Sofia , Tams Spiro , Ramot Yuval , Zlotogorski Abraham , Molho‐Pessach Vered 
Published: June 2014

AbstractDeficiency of interleukin‐36 (IL‐36) receptor antagonist (DITRA; OMIM 614204) is a rare autoinflammatory disorder characterized by periodic fever associated with a generalized erythematous and pustular skin rash. A 6‐year‐old Arab‐Palestinian boy presented with a history of periodic fever and unremitting, erythematous, scaly skin rash accompanied by widespread pustules that had been present since the age of one month. The patient's skin lesions were compatible with generalized pustular psoriasis. Sequence analysis revealed a homozygous nonsense mutation, c.28C>T (p.Arg10X) in the IL36RN gene. The patient improved with oral methotrexate in combination with oral and topical corticosteroids. The molecular basis for DITRA has only recently been identified, and the mutation spectrum for this disorder in many populations is still obscure. This paper reports the presence of the c.28C>T mutation in an Arab‐Palestinian patient and thus represents the first description of this mutation in a non‐Japanese subject.
A rare case of subcutaneous phaeohyphomycosis caused by aRhytidhysteronspecies: a clinico‐therapeutic experience
Authors: Mahajan Vikram K. , Sharma Vikas , Prabha Neel , Thakur Kamlesh , Sharma Nand Lal , Rudramurthy Shivaprakash M. , Chauhan Pushpinder S. , Mehta Karaninder S. , Abhinav C. 
Published: June 2014

AbstractBackgroundSubcutaneous phaeohyphomycosis usually results from traumatic inoculation with the fungus and generally occurs in immunosuppressed men.Cladosporium,Exophiala, andAlternariaspp. are commonly implicated pathogens.ObjectivesWe present a case of subcutaneous phaeohyphomycosis caused byRhytidhysteronsp. that was refractory to conventional antifungal therapy.Case reportA 72‐year‐old man with hypertension and diabetes presented with a multiloculated, large cystic swelling over the right dorsal foot. Laboratory findings and x‐rays of the chest and left foot were normal.ResultsAdequate control of the patient's diabetes was achieved, and the swelling was excised under itraconazole/terbinafine coverage. Histology showed multiple areas of neutrophilic abscess, epithelioid cells, foreign body giant cells, and multiple septate hyphae and yeast‐like cells. Dematiaceous fungus was cultured but failed to produce spores. Sequencing of the isolate showed a match of > 99% withRhytidhysteron rufulum. The patient demonstrated no response after one year of therapy with itraconazole/terbinafine. Weekly infiltration of the lesion with liposomal amphotericin B resulted in its complete resolution within 15 weeks.ConclusionsLesions of phaeohyphomycosis appear morphologically similar regardless of the organism implicated. Hence, their diagnosis rests entirely on the clinicopathological and microbiological presentation. Molecular studies may be required to identify a fungus if attempts to grow it in artificial culture media fail.Rhytidhysteronspp. are not known as pathogens in humans, and no treatment protocol exists. Intralesional amphotericin was highly effective in our patient and caused no systemic adverse effects. Voriconazole and posaconazole are effective against disseminated/visceral phaeohyphomycotic infections, but their efficacy againstRhytidhysteronspp. remains unstudied.
MDR1 C3435T polymorphism associated with the development of clinical features in Behçet's disease in Iranian Azeri Turkish patients
Authors: Bonyadi Mortaza , Gholizadeh Monireh , Soltan‐Ali Mahboob 
Published: June 2014

AbstractBackgroundBehçet's disease (BD) is a systemic vasculitis of unknown cause with a higher prevalence along the ancient Silk Road. Behçet's occasional familial aggregation and its close association with genes of major histocompatibility complexes justify that genetic factors play an important role in the development of the disease. In this study, we evaluated the association of multidrug resistance (MDR1) C3435T polymorphism with the severity of BD.MethodWe investigated the distribution of MDR1 C3435T polymorphism in 69 patients from the Iranian Azeri Turks group with BD and 92 ethnically sex‐matched healthy controls, via the polymerase chain reaction–restriction fragment length polymorphism technique.ResultAlthough there was no significant association of MDR1 C3435T polymorphism between two groups of patients and healthy controls, our data showed a substantial association of CC genotype with the development of several clinical features, including erythema nodosum (P = 0.001, OR = 2.686, 95%), pseudofolliculitis (P = 0.002, OR = 2.812, 95%), and skin lesions (P = 0.040, OR = 1.934, 95%).ConclusionThese results suggest that CC genotype is a risk factor for the development of some clinical features of BD in patients from the Iranian Azeri Turk ethnic group.
Effects of a diabetes prevention programme on weight‐specific quality of life in Latino youth
Authors: Brito E. , Patrick D. L. , Konopken Y. P. , Keller C. S. , Barroso C. S. , Shaibi G. Q. 
Published: June 2014

SummaryObjectiveTo examine the effects of a diabetes prevention programme on weight‐specific Quality of Life (QOL) in obese Latino youth.MethodsFifteen obese Latino adolescents (body mass index % = 96.4 ± 1.2; age = 15.0 ± 1.0) completed a 12‐week culturally grounded, community‐based intervention designed to improve physical and psychosocial health. Weight‐specific QOL was assessed by the Youth Quality of Life‐Weight module and compared with age, sex and ethnicity‐matched lean youth.ResultsAt baseline, intervention youth exhibited significantly lower weight‐specific QOL compared with lean youth (70.8 ± 5.4 vs. 91.2 ± 2.2, P = 0.002). However, following the intervention, total weight‐specific QOL increased by 21.8% among obese youth (70.8 ± 5.4 to 86.2 ± 4.3, P < 0.001) and was no longer different from lean controls. Significant increases in weight‐specific QOL were noted across all subdomains including self (45.7%), social (11.9%) and environmental (36.2%) despite the fact that weight did not change (90.6 ± 6.8 to 89.9 ± 7.2, P = 0.44). The improvements in QOL were maintained for up to 12 months after the intervention.ConclusionWeight‐specific QOL among obese Latino youth can be improved through lifestyle interventions to a level similar to lean peers. Further, weight loss may not be necessary to observe improvements in QOL.
Efficacy of repeated exposure and flavour–flavour learning as mechanisms to increase preschooler's vegetable intake and acceptance
Authors: de Wild V. , de Graaf C. , Jager G. 
Published: June 2014

SummaryBackgroundDutch children's diets, like the diets of many children in Europe and the US are not balanced, do not contain enough vegetables and have been associated with a high prevalence of childhood obesity. Promoting children's vegetable intake is challenging.ObjectiveWe investigated the relative effectiveness of repeated exposure and flavour–flavour learning in increasing vegetable intake and acceptance in preschoolers.MethodsDuring an intervention period of 7 weeks, 39 toddlers (aged 1.5 to 4 years) consumed red beet and parsnip crisps at day‐care centres in Wageningen, the Netherlands. Half of the group received red beet crisps with a dip of tomato ketchup (Conditioned [C]) and parsnip with a neutral white sauce (Unconditioned, [UC]), whereas for the other half the order was reversed (red beet [UC], parsnip [C]). Preference and ad libitum consumption of vegetable crisps were measured once before and three times after the intervention over the course of a 6‐month follow‐up period to assess longer‐term effects.ResultsIntake increased significantly after the intervention for both vegetables (on average with 8 g; an increase of approximately 300%), and this effect was persistent even 6 months afterwards. The increase was irrespective of crisps being offered with C or UC dip sauce.ConclusionsThese results suggest a robust and persistent effect of repeated exposure but no effect of flavour–flavour learning. Offering pure vegetable tastes repeatedly is sufficient to increase intake.
Urtica dioica for treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia
Authors: Hosseinabadi Reza , Heidari Mohammad , Anbari Khatereh , Pournia Yadollah 
Published: June 2014

ABSTRACTBenign prostatic hyperplasia (BPH) is a common problem of the elderly population. This study was conducted to investigate the effect of Urtica dioica on the clinical symptoms of BPH. This double‐blind clinical trial included 248 patients with symptomatic BPH in Shohada Ashayer Hospital of Khorramabad. The patients were randomly divided into four groups of treatment with U. dioica 3 g, U. dioica 5 g, U. dioica 7 g and treatment with prazosin 1 mg alone as the control group. The clinical symptoms, patients' quality of life and level of serum prostate‐specific antigen (PSA) were measured before and 2 months after the intervention. The results of the study showed significant differences between the four groups after the intervention for the scores of clinical symptoms and patients' quality of life, while no significant differences were found for serum PSA levels. Sheffe post hoc comparisons showed significant improvements in the scores of the patients' clinical symptom in the U. dioica 5 g/d and U. dioica 7 g/d groups. The results of the study showed that simultaneous consumption of higher doses of U. dioica, up to 7 g/d, plus prazosin, compared with the consumption of prazosin alone, resulted in significant improvements in the clinical symptoms of BPH.
In VitroMechanical Testing of Braided Polyurethane Elastic Fiber and Braided Polyester for Equine Laryngoplasty
Authors: Willsallen Hadley , Heller Jane , Kark Lauren , Hilbert Bryan J. 
Published: June 2014

ObjectivesIn vitrocomparison of the mechanical properties of braided polyurethane elastomer (Lycra®) and braided polyester (Ethibond™) (1) when inserted into the muscular process of the arytenoid cartilage and (2) as suture loops.Study DesignExperimental.AnimalsEquine cadaver larynges (n = 15).MethodsThe muscular processes (n = 30) of the arytenoid cartilages were dissected from each larynx and embedded in a resin base. Lycra® and Ethibond™ prostheses were randomly allocated to the left or right muscular process and each underwent cyclic fatigue (25–50 N) followed by load‐to‐failure testing.Isolated suture loops of Lycra® (n = 25) and Ethibond™ (n = 25) also underwent the same cyclic fatigue followed by load‐to‐failure testing (n = 20) or a creep testing protocol (25 N for 10 min; n = 5).ResultsLycra® prostheses pulled through the cartilage in a significantly greater proportion of cyclic tests (P = .015) and at lower mean (±SD) loads, (95.9 ± 23.4 N) during load‐to‐failure testing than Ethibond™ prostheses (155.2 ± 24.4 N;P = .0041). Lycra® had a significantly greater displacement with and without a cartilage interface when compared to Ethibond™ (P < .001,P < .002). The Lycra® isolated suture loops failed at significantly greater loads (233.0 ± 38.7 N) during load‐to‐failure testing than Ethibond™ loops (201.6 ± 47.4 N;P = .042).ConclusionsLycra® prostheses embedded in laryngeal cartilage pulled through the cartilage at lower loads than Ethibond™ prostheses. Lycra® suture loops were stronger than Ethibond™ suture loops. Lycra® had greater displacement than Ethibond™ in all tests as suture loops or when embedded in cartilage.
Laparoscopic Extirpation of the Medial Iliac Lymph Nodes in Normal Dogs
Authors: Steffey Michele A. , Daniel Leticia , Mayhew Philipp D. , Affolter Verena K. , Soares Joao H.N. , Fuller Mark C. 
Published: June 2014

ObjectiveTo describe a surgical technique for laparoscopic medial iliac lymph node (MILN) extirpation, and to describe the quality of biopsy specimens obtained.DesignExperimental study.AnimalsPurpose‐bred male hound‐mix research dogs (n = 8).MethodsDogs were randomized to groups of left or right‐sided laparoscopic surgical approaches. Three transperitoneal portals were established with the dogs in lateral recumbency, and ipsilateral MILN dissection was achieved under CO2 pneumoperitoneum using a vessel‐sealing device.ResultsMILN ipsilateral to the approach were successfully identified and removed laparoscopically in 8 dogs. Observed complications included mild to moderate hemorrhage that was controlled laparoscopically in 4 dogs, and tearing of the MILN capsule during retraction and dissection in 3 dogs. No other major complications occurred and all dogs recovered uneventfully. Areas of either minor peripheral (9/9) or central (4/9) pinch artifact affected a median percentage of 5% of surface area (range, 5–30%) of bisected lymph nodes.ConclusionsLaparoscopic MILN extirpation is feasible in dogs with normal MILN and may serve as a minimally invasive approach for excisional biopsy in the diagnostic staging of canine onocologic patients with normal‐sized MILN. This lateral laparoscopic approach allows dissection of the ipsilateral MILN but precludes removal of the contralateral MILN. Minimal handling of the lymph node during dissection and removal is required to reduce the risk of capsular tear, or introduction of possible histologic artifact by tissue crush that may impact diagnosis.
Canine Intrahepatic Vasculature: Is a Functional Anatomic Model Relevant to the Dog?
Authors: Hall Jon L. , Mannion Paddy , Ladlow Jane F. 
Published: June 2014

ObjectiveTo clarify canine intrahepatic portal and hepatic venous system anatomy using corrosion casting and advanced imaging and to devise a novel functional anatomic model of the canine liver to investigate whether this could help guide the planning and surgical procedure of partial hepatic lobectomy and interventional radiological procedures.Study DesignProspective experimental study.AnimalsAdult Greyhound cadavers (n = 8).MethodsPortal and hepatic vein corrosion casts of healthy livers were assessed using computed tomography (CT).ResultsThe hepatic lobes have a consistent hilar hepatic and portal vein supply with some variation in the number of intrahepatic branches. For all specimens, 3 surgically resectable areas were identified in the left lateral lobe and 2 surgically resectable areas were identified in the right medial lobe as defined by a functional anatomic model.ConclusionsCT of detailed acrylic casts allowed complex intrahepatic vascular relationships to be investigated and compared with previous studies. Improving understanding of the intrahepatic vascular supply facilitates interpretation of advanced images in clinical patients, the planning and performance of surgical procedures, and may facilitate interventional vascular procedures, such as intravenous embolization of portosystemic shunts. Functional division of the canine liver similar to human models is possible. The left lateral and right medial lobes can be consistently divided into surgically resectable functional areas and partial lobectomies can be performed following a functional model; further study in clinically affected animals would be required to investigate the relevance of this functional model in the dog.
Catheter Ablation of Asymptomatic Longstanding Persistent Atrial Fibrillation: Impact on Quality of Life, Exercise Performance, Arrhythmia Perception, and Arrhythmia‐Free Survival
Authors: MOHANTY SANGHAMITRA , SANTANGELI PASQUALE , MOHANTY PRASANT , BIASE LUIGI DI , HOLCOMB SHAWNA , TRIVEDI CHINTAN , BAI RONG , BURKHARDT DAVID , HONGO RICHARD , HAO STEVEN , BEHEIRY SALWA , SANTORO FRANCESCO , FORLEO GIOVANNI , GALLINGHOUSE JOSEPH G. , HORTON RODNEY , SANCHEZ JAVIER E. , BAILEY SHANE , HRANITZKY PATRICK M. , ZAGRODZKY JASON , NATALE ANDREA 
Published: June 2014

Ablation Outcome in Silent Longstanding Persistent AFBackgroundImpact of catheter ablation on exercise performance, quality of life (QoL) and symptom perception in asymptomatic longstanding persistent AF (LSP‐AF) patients has not been reported yet.Methods and ResultsSixty‐one consecutive patients (mean age 62 ±13 years, 71% males) with asymptomatic LSP‐AF undergoing first catheter ablation were enrolled. Extended pulmonary vein antrum isolation plus ablation of complex fractionated atrial electrograms and nonpulmonary vein triggers was performed in all. QoL survey was taken at baseline and 12‐months postablation, using Short Form‐36 (SF‐36). Information on arrhythmia perception was obtained using a standard questionnaire and corroborating symptoms with documented evidence of arrhythmia. Exercise tests were performed on 38 patients at baseline and 5 months after procedure. Recurrence was assessed using event recorder, cardiology evaluation, electrocardiogram, and 7‐day holter monitoring. After 20 ± 5 months follow‐up, 36 (57%) patients remained recurrence‐free off‐AAD. Of the 25 patients experiencing recurrence, 21 (84%) were symptomatic. Compared to baseline, follow‐up SF‐36 scores improved significantly in many measures. For patients with successful ablation, physical component summary (PCS) and mental component summary (MCS) demonstrated substantial improvement (MCS: 64.2 ± 22.3 to 70.1 ± 18.6 [P = 0.041]; PCS: 62.6 ± 18.4 to 70.0 ± 14.4 [P = 0.032]). Postablation exercise study in recurrence‐free patients showed significant reduction in resting and peak heart rate (75 ± 11 vs. 90 ± 17 and 132 ± 20 vs. 154.5 ± 36, respectively, P < 0.001), increase in peak oxygen pulse (13.4 ± 3 vs. 18.9 ± 16 mL/beat, Δ5.5 ± 15, P = 0.001), peak VO2/kg (19.7 ± 5 to 23.4 ± 13 mL/kg/min [Δ 3.7 ± 10, P = 0.043]), and corresponding MET (5.6 ± 1 to 6.7 ± 4 [Δ1.1 ± 3, P = 0.03]). No improvement was observed in patients with failed procedures.ConclusionSuccessful ablation improves exercise performance and QoL in asymptomatic LSP‐AF patients.
Long‐Term Outcome of Catheter Ablation in Atrial Fibrillation Patients with Coexistent Metabolic Syndrome and Obstructive Sleep Apnea: Impact of Repeat Procedures versus Lifestyle Changes
Authors: MOHANTY SANGHAMITRA , MOHANTY PRASANT , DI BIASE LUIGI , BAI RONG , TRIVEDI CHINTAN , SANTANGELI PASQUALE , SANTORO FRANCESCO , HONGO RICHARD , HAO STEVEN , BEHEIRY SALWA , BURKHARDT DAVID , GALLINGHOUSE JOSEPH G. , HORTON RODNEY , SANCHEZ JAVIER E. , BAILEY SHANE , HRANITZKY PATRICK M. , ZAGRODZKY JASON , NATALE ANDREA 
Published: June 2014

Ablation Outcome in AF with Concurrent MS and OSAIntroductionMetabolic syndrome (MS) and obstructive sleep apnea (OSA) are well‐known independent risk factors for atrial fibrillation (AF) recurrence. This study evaluated ablation outcome in AF patients with coexistent MS and OSA and influence of lifestyle modifications (LSM) on arrhythmia recurrence.Methods and ResultsWe included 1,257 AF patients undergoing first catheter ablation (30% paroxysmal AF). Patients having MS + OSA were classified into Group 1 (n = 126; 64 ± 8 years; 76% male). Group 2 (n = 1,131; 62 ± 11 years; 72% male) included those with either MS (n = 431) or OSA (n = 112; no CPAP users) or neither of these comorbidities (n = 588). Patients experiencing recurrence after first procedure were divided into 2 subgroups; those having sporadic events (frequency < 2 months) remained on previously ineffective antiarrhythmic drugs (AAD) and aggressive LSM, while those with persistent arrhythmia (incessant or ≥2 months) underwent repeat ablation.After 34 ± 8 months of first procedure, 66 (52%) in Group 1 and 386 (34%) in Group 2 had recurrence (P < 0.001). Recurrence rate in only‐MS, only‐OSA, and without MS/OSA groups were 40%, 38%, and 29%, respectively. Patients with MS + OSA experienced substantially higher recurrence compared to those with lone MS or OSA (52% vs. 40% vs. 38%; P = 0.036). Of the 452 patients having recurrence, 250 underwent redo‐ablation and 194 remained on AAD and LSM. At 20 ± 6 months, 76% of the redo group remained arrhythmia‐free off AAD whereas 74% of the LSM group were free from recurrence (P = 0.71), 33% of which were off AAD.ConclusionsMS and OSA have additive negative effect on arrhythmia recurrence following single procedure. Repeat ablation or compliant LSM increase freedom from recurrent AF.
Circumstances and causes of falls by patients at a Spanish acute care hospital
Authors: Aranda‐Gallardo Marta , Morales‐Asencio Jose Miguel , Canca‐Sanchez Jose Carlos , Toribio‐Montero Juan Carlos 
Published: June 2014

AbstractRationale, aims and objectivesA major problem in hospitals is that of falls, which can seriously reduce patients' quality of life. Fall rates vary considerably depending on health care practices, the hospital environment and the measurement method used. The aim of this study was to determine the characteristics of hospitalized acute patients who suffer falls, by analysing the distribution and the profile of these patients.MethodsThis is an analytic cross‐sectional study conducted at a Spanish hospital. All patients who suffered a fall during hospitalization in 2011 were studied by analysing the computerized register of falls. Downton index, circumstances and consequences of falls were analysed. Descriptive statistics, bivariate analysis and logistic regression analysis were performed.ResultsThe frequency of falls was 0.64%. The rate of falls increased with age (mean age: 71.06 years). The highest percentage occurred among patients in the medical care area (63.7%). The probability of suffering a fall was 1.33 times higher among men than women. Differences in age, type of risk of fall and circumstances were found, depending on the type of hospitalization. Multivariate analysis revealed that patients in the medical care area suffered more falls with consequences: 7.01 [95% confidence interval (CI): 1.34–36.79], as did the patients classified as ‘low risk’: 2.40 (CI 95%: 1.02–5.65).ConclusionsFalls have diverse causes. Determining these circumstances can contribute to promoting a culture of prevention and to reducing the injuries provoked by falls. Notification procedures should be standardized in order to enable comparisons among different environments.