bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strong variable linear polarization in the cool active star II Peg
Authors: Rosén Lisa , Kochukhov Oleg , Wade Gregg A. 
Published: August 2014

AbstractMagnetic fields of cool active stars are currently studied polarimetrically using only circular polarization observations. This provides limited information about the magnetic field geometry since circular polarization is only sensitive to the line-of-sight component of the magnetic field. Reconstructions of the magnetic field topology will therefore not be completely trustworthy when only circular polarization is used. On the other hand, linear polarization is sensitive to the transverse component of the magnetic field. By including linear polarization in the reconstruction the quality of the reconstructed magnetic map is dramatically improved. For that reason, we wanted to identify cool stars for which linear polarization could be detected at a level sufficient for magnetic imaging. Four active RS CVn binaries, II Peg, HR 1099, IM Peg, and σ Gem were observed with the ESPaDOnS spectropolarimeter at the Canada-France-Hawaii Telescope. Mean polarization profiles in all four Stokes parameters were derived using the multi-line technique of least-squares deconvolution (LSD). Not only was linear polarization successfully detected in all four stars in at least one observation, but also, II Peg showed an extraordinarily strong linear polarization signature throughout all observations. This qualifies II Peg as the first promising target for magnetic Doppler imaging in all four Stokes parameters and, at the same time, suggests that other such targets can possibly be identified.
Activity on a Li-rich giant: DI Psc revisited
Authors: Kriskovics Levente , Kővári Zsolt , Vida Krisztián , Oláh Katalin 
Published: August 2014

AbstractWe present a new Doppler imaging study for the Li-rich single K-giant DI Psc. Surface temperature maps are reconstructed for two subsequent rotation cycles. From the time evolution of the spot distribution antisolar-type differential rotation pattern is revealed. We show marks of non-uniform Li-abundance as well. The possible connection between the current evolutionary phase of the star and its magnetic activity is briefly discussed.
Search for surface magnetic fields in Mira stars: first results on χ Cyg
Authors: Lèbre Agnès , Aurière Michel , Fabas Nicolas , Gillet Denis , Herpin Fabrice , Petit Pascal , Konstantinova-Antova Renada 
Published: August 2014

AbstractSo far, surface magnetic fields have never been reported on Mira stars, while observational facilities allowing detection and measurement of weak surface fields through the Zeeman effect have become available. Then, in order to complete the knowledge of the magnetic field and of its influence during the transition from Asymptotic Giant Branch (AGB) to Planetary Nebulae (PN) stages, we have undertaken a search for magnetic fields at the surface of Miras. We present the first spectropolarimetric observations (performed with the Narval instrument at Télescope Bernard Lyot-TBL, Pic du Midi, France) of the S-type Mira star χ Cyg. We have detected a polarimetric signal in the Stokes V spectra and we have established its Zeeman origin. We claim that it is likely to be related to a weak magnetic field present at the photospheric level and in the lower part of the stellar atmosphere. The origin of this magnetic field is discussed in the framework of shock waves periodically propagating throughout the atmosphere of a Mira.
Magnetic fields around AGB stars and Planetary Nebulae
Authors: Vlemmings W. H. T. 
Published: August 2014

AbstractStars with a mass up to a few solar masses are one of the main contributors to the enrichment of the interstellar medium in dust and heavy elements. However, while significant progress has been made, the process of the mass-loss responsible for this enrichment is still not exactly known and forces beyond radiation pressure might be required. Often, the mass lost in the last phases of the stars life will become a spectacular planetary nebula. The shaping process of often strongly a-spherical PNe is equally elusive. Both binaries and magnetic fields have been suggested to be possible agents although a combination of both might also be a natural explanation.Here I review the current evidence for magnetic fields around AGB and post-AGB stars pre-Planetary Nebulae and PNe themselves. Magnetic fields appear to be ubiquitous in the envelopes of apparently single stars, challenging current ideas on its origin, although we have found that binary companions could easily be hidden from view. There are also strong indications of magnetically collimated outflows from post-AGB/pre-PNe objects supporting a significant role in shaping the circumstellar envelope.
Improving productive efficiency in hospitals: findings from a review of the international evidence
Authors: Rumbold Benedict E. , Smith Judith A. , Hurst Jeremy , Charlesworth Anita , Clarke Aileen 
Published: August 2014

AbstractAt present, health systems across Europe face the same challenges: a changing demographic profile, a rise in multi-morbidity and long-term conditions, increasing health care costs, large public debts and other legacies of an economic downturn. In light of these concerns, this article provides an overview of the international evidence on how to improve productive efficiency in secondary care settings. Updating and expanding upon a recent review of the literature by Hurst and Williams (2012), we set out evidence on potential interventions in the policy environment, hospital management, and operational processes. We conclude with five key lessons for policy makers and practitioners on how to improve productive efficiency within hospital settings, and identify several gaps in the existing evidence base.
A metal–ion-responsive adhesive material via switching of molecular recognition properties
Authors: Nakamura Takashi , Takashima Yoshinori , Hashidzume Akihito , Yamaguchi Hiroyasu , Harada Akira 
Published: August 2014

AbstractCommon adhesives stick to a wide range of materials immediately after they are applied to the surfaces. To prevent indiscriminate sticking, smart adhesive materials that adhere to a specific target surface only under particular conditions are desired. Here we report a polymer hydrogel modified with both β-cyclodextrin (βCD) and 2,2′-bipyridyl (bpy) moieties (βCD–bpy gel) as a functional adhesive material responding to metal ions as chemical stimuli. The adhesive property of βCD–bpy gel based on interfacial molecular recognition is expressed by complexation of metal ions to bpy that controlled dissociation of supramolecular cross-linking of βCD–bpy. Moreover, adhesion of βCD–bpy gel exhibits selectivity on the kinds of metal ions, depending on the efficiency of metal–bpy complexes in cross-linking. Transduction of two independent chemical signals (metal ions and host–guest interactions) is achieved in this adhesion system, which leads to the development of highly orthogonal macroscopic joining of multiple objects.
Epiphytic leafy liverworts diversified in angiosperm-dominated forests
Authors: Feldberg Kathrin , Schneider Harald , Stadler Tanja , Schäfer-Verwimp Alfons , Schmidt Alexander R. , Heinrichs Jochen 
Published: August 2014

AbstractRecent studies have provided evidence for pulses in the diversification of angiosperms, ferns, gymnosperms and mosses as well as various groups of animals during the Cretaceous revolution of terrestrial ecosystems. However, evidence for such pulses has not been reported so far for liverworts. Here we provide new insight into liverwort evolution by integrating a comprehensive molecular dataset with a set of 20 fossil age constraints. We found evidence for a relative constant diversification rate of generalistic liverworts (Jungermanniales) since the Palaeozoic, whereas epiphytic liverworts (Porellales) show a sudden increase of lineage accumulation in the Cretaceous. This difference is likely caused by the pronounced response of Porellales to the ecological opportunities provided by humid, megathermal forests, which were increasingly available as a result of the rise of the angiosperms.
Novel ultra-low temperature co-fired microwave dielectric ceramic at 400 degrees and its chemical compatibility with base metal
Authors: Di Zhou , Li-Xia Pang , Ze-Ming Qi , Biao-Bing Jin , Xi Yao 
Published: August 2014

AbstractA novel NaAgMoO4 material with spinel-like structure was synthesized by using the solid state reaction method and the ceramic sample was well densified at an extreme low sintering temperature about 400°C. Rietveld refinement of the crystal structure was performed using FULLPROF program and the cell parameters are a = b = c = 9.22039 Å with a space group F D −3 M (227). High performance microwave dielectric properties, with a permittivity ~7.9, a Qf value ~33,000 GHz and a temperature coefficient of resonant frequency ~−120 ppm/°C, were obtained. From X-ray diffraction (XRD) and Energy Dispersive Spectrometer (EDS) analysis of the co-fired sample, it was found that the NaAgMoO4 ceramic is chemically compatible with both silver and aluminum at the sintering temperature and this makes it a promising candidate for the ultra-low temperature co-fired ceramics technology. Analysis of infrared and THz spectra indicated that dielectric polarizability at microwave region of the NaAgMoO4 ceramic was equally contributed by ionic displasive and electronic polarizations. Its small microwave dielectric permittivity can also be explained well by the Shannon's additive rule.
The newly identified migration inhibitory protein regulates the radial migration in the developing neocortex
Authors: Zhang Suxiang , Kanemitsu Yoshitaka , Fujitani Masashi , Yamashita Toshihide 
Published: August 2014

AbstractNeuronal migration is a crucial process in the organization of the developing cerebral cortex. Although a number of positive regulatory mechanisms of radial migration have been identified, negative cell-autonomous mechanisms have yet to be fully described. Here we report a newly identified Migration Inhibitory Protein (MINP, formerly known as 2900011O08Rik) that negatively regulates radial migration. MINP mRNA was specifically detected in the central and peripheral nervous system and especially enriched in the cerebral cortex. MINP immunoreactivity co-localized with the neuronal marker Tuj1 and was detected in the cytoplasm of post-mitotic neurons. To elucidate the function of MINP in the developing brain, we performed in utero electroporation of MINP siRNA, MINP shRNA, or MINP-overexpressing vectors into mouse cortices and carried out in vivo migration assays. Whereas knockdown of MINP did not alter neuronal morphology, the radial migration was found accelerated by MINP knockdown and reduced by MINP overexpression. This migration phenotype was also confirmed in vitro, indicating that MINP regulates neuronal migration in a cell-autonomous fashion. Furthermore, downregulation of MINP affected microtubule stability by interacting with tubulin that is a potential mechanism involved in the regulation of neuronal migration.
Adenylate cyclase-centred microdomains
Authors: Cooper Dermot M. F. , Tabbasum Valentina G. 
Published: August 2014

Recent advances in the AC (adenylate cyclase)/cAMP field reveal overarching roles for the ACs. Whereas few processes are unaffected by cAMP in eukaryotes, ranging from the rapid modulation of ion channel kinetics to the slowest developmental effects, the large number of cellular processes modulated by only three intermediaries, i.e. PKA (protein kinase A), Epacs (exchange proteins directly activated by cAMP) and CNG (cyclic nucleotide-gated) channels, poses the question of how selectivity and fine control is achieved by cAMP. One answer rests on the number of differently regulated and distinctly expressed AC species. Specific ACs are implicated in processes such as insulin secretion, immunological responses, sino-atrial node pulsatility and memory formation, and specific ACs are linked with particular diseased conditions or predispositions, such as cystic fibrosis, Type 2 diabetes and dysrhythmias. However, much of the selectivity and control exerted by cAMP lies in the sophisticated properties of individual ACs, in terms of their coincident responsiveness, dynamic protein scaffolding and organization of cellular microassemblies. The ACs appear to be the centre of highly organized microdomains, where both cAMP and Ca2+, the other major influence on ACs, change in patterns quite discrete from the broad cellular milieu. How these microdomains are organized is beginning to become clear, so that ACs may now be viewed as fundamental signalling centres, whose properties exceed their production of cAMP. In the present review, we summarize how ACs are multiply regulated and the steps that are put in place to ensure discrimination in their signalling. This includes scaffolding of targets and modulators by the ACs and assembling of signalling nexuses in discrete cellular domains. We also stress how these assemblies are cell-specific, context-specific and dynamic, and may be best addressed by targeted biosensors. These perspectives on the organization of ACs uncover new strategies for intervention in systems mediated by cAMP, which promise far more informed specificity than traditional approaches.
Structures of lipoyl synthase reveal a compact active site for controlling sequential sulfur insertion reactions
Authors: Harmer Jenny E. , Hiscox Martyn J. , Dinis Pedro C. , Fox Stephen J. , Iliopoulos Andreas , Hussey James E. , Sandy James , Van Beek Florian T. , Essex Jonathan W. , Roach Peter L. 
Published: August 2014

Lipoyl cofactors are essential for living organisms and are produced by the insertion of two sulfur atoms into the relatively unreactive C–H bonds of an octanoyl substrate. This reaction requires lipoyl synthase, a member of the radical S-adenosylmethionine (SAM) enzyme superfamily. In the present study, we solved crystal structures of lipoyl synthase with two [4Fe–4S] clusters bound at opposite ends of the TIM barrel, the usual fold of the radical SAM superfamily. The cluster required for reductive SAM cleavage conserves the features of the radical SAM superfamily, but the auxiliary cluster is bound by a CX4CX5C motif unique to lipoyl synthase. The fourth ligand to the auxiliary cluster is an extremely unusual serine residue. Site-directed mutants show this conserved serine ligand is essential for the sulfur insertion steps. One crystallized lipoyl synthase (LipA) complex contains 5′-methylthioadenosine (MTA), a breakdown product of SAM, bound in the likely SAM-binding site. Modelling has identified an 18 Å (1 Å=0.1 nm) deep channel, well-proportioned to accommodate an octanoyl substrate. These results suggest that the auxiliary cluster is the likely sulfur donor, but access to a sulfide ion for the second sulfur insertion reaction requires the loss of an iron atom from the auxiliary cluster, which the serine ligand may enable.
Energetically significant networks of coupled interactions within an unfolded protein
Authors: Cho Jae-Hyun , Meng Wenli , Sato Satoshi , Kim Eun Young , Schindelin Hermann , Raleigh Daniel P. 
Published: August 2014

Significance
Unfolded and partially unfolded proteins participate in a wide range of biological processes from pathological aggregation to the regulation of normal cellular activity. Characterization of nonnative states is critical for the understanding of these processes, yet comparatively little is known about their energetics and their structural propensities under native conditions. We demonstrate that energetically important interactions, which involve multiple residues and which include significant nonnative effects, can form in the denatured state ensemble (DSE) of globular proteins, and can involve residues that are distant in sequence and spatially well separated in the native structure. Mutations that alter the energetics of the DSE can impact the analysis of cooperativity and folding, and could modulate the propensity to aggregate.
Assessment of Fat Reserves Adequacy in the First Migrant Silver American Eels of a Large-Scale Stocking Experiment
Authors: Couillard Catherine M. , Verreault Guy , Dumont Pierre , Stanley David , Threader Ron W. 
Published: August 2014

Abstract
An experimental stocking program in the St. Lawrence River–Lake Ontario system provided a unique opportunity to compare reproductive fitness of migrant silver American Eels Anguilla rostrata from the stocking program (SM) and wild migrants (WM), both of which were grown in the same location. Body size, muscle lipid stores, oocyte development, and morphometric indices of silvering were compared between SM and WM eels captured in the St. Lawrence River estuary. Migrant eels from the stocking program were smaller than wild migrants from the estuary, but their size was similar to migrating wild silver American Eels from their site of original capture on the Atlantic coast of New Brunswick and Nova Scotia. A bioenergetic model was used to estimate the costs of migration and reproduction and the duration of migration. The adequacy of the measured lipid reserves to meet these estimated energetic costs was assessed for SM and WM eels. Gonad maturation and stage of silvering for SM eels were less advanced than that for WM eels, and they had lower initial muscle fat reserves and higher estimated energetic requirements for migration as a consequence of their smaller size. It was estimated that 100% of the SM eels would not have adequate fat reserves for migration and reproduction, whereas 57% of the WM eels would have adequate reserves. Smaller-sized SM eels would take 1.6 times longer to reach the spawning grounds than WM eels and, thus, may not arrive in synchrony with these wild migrants. Thus, smaller-sized, out-migrating, stocked eels from the upper St. Lawrence River are less likely than wild migrants to complete successfully their migration and reproduction. These results support the recommendation to source and stock American Eels at sites where they have similar life strategies to increase the likelihood of successful silver eel escapement.
Received November 27, 2013; accepted April 9, 2014
Toward Enhancing 12-Step Facilitation among Young People: A Systematic Qualitative Investigation of Young Adults’ 12-Step Experiences
Authors: Labbe Allison K. , Slaymaker Valerie , Kelly John F. 
Published: August 2014

Background 12-Step Facilitation (TSF) interventions designed to enhance rates of engagement with 12-step mutual-help organizations (MHOs) have shown efficacy among adults, but research provides little guidance on how to adapt TSF strategies for young people. Methods To inform TSF strategies for youth, this study used qualitative methods to investigate the self-reported experiences of 12-step participation, and reasons for nonattendance and discontinuation among young adults (18–24 years; N = 302). Responses to open-ended questions following residential treatment were coded into rationally derived domains. Results Young adults reported that cohesiveness, belonging, and instillation of hope were the most helpful aspects of attending 12-step groups; meeting structure and having to motivate oneself to attend meetings were the most common aspects young adults liked least; logistical barriers and low recovery motivation and interest were the most common reasons for discontinued attendance; and perceptions that one did not have a problem or needed treatment were cited most often as reasons for never attending. Conclusions Findings may inform and enhance strategies intended to engage young people with community-based recovery-focused 12-step MHOs and ultimately improve recovery outcomes.
BioTextQuest
+
: a knowledge integration platform for literature mining and concept discovery
Authors: Papanikolaou Nikolas , Pavlopoulos Georgios A. , Pafilis Evangelos , Theodosiou Theodosios , Schneider Reinhard , Satagopam Venkata P. , Ouzounis Christos A. , Eliopoulos Aristides G. , Promponas Vasilis J. , Iliopoulos Ioannis 
Published: August 2014

Abstract
Summary: The iterative process of finding relevant information in biomedical literature and performing bioinformatics analyses might result in an endless loop for an inexperienced user, considering the exponential growth of scientific corpora and the plethora of tools designed to mine PubMed ® and related biological databases. Herein, we describe BioTextQuest + , a web-based interactive knowledge exploration platform with significant advances to its predecessor (BioTextQuest), aiming to bridge processes such as bioentity recognition, functional annotation, document clustering and data integration towards literature mining and concept discovery. BioTextQuest + enables PubMed and OMIM querying, retrieval of abstracts related to a targeted request and optimal detection of genes, proteins, molecular functions, pathways and biological processes within the retrieved documents. The front-end interface facilitates the browsing of document clustering per subject, the analysis of term co-occurrence, the generation of tag clouds containing highly represented terms per cluster and at-a-glance popup windows with information about relevant genes and proteins. Moreover, to support experimental research, BioTextQuest + addresses integration of its primary functionality with biological repositories and software tools able to deliver further bioinformatics services. The Google-like interface extends beyond simple use by offering a range of advanced parameterization for expert users. We demonstrate the functionality of BioTextQuest + through several exemplary research scenarios including author disambiguation, functional term enrichment, knowledge acquisition and concept discovery linking major human diseases, such as obesity and ageing.
Availability: The service is accessible at http://bioinformatics.med.uoc.gr/biotextquest .
Contact: g.pavlopoulos@gmail.com or georgios.pavlopoulos@esat.kuleuven.be
Supplementary information: Supplementary data are available at Bioinformatics online.
MEGADOCK 4.0: an ultra–high-performance protein–protein docking software for heterogeneous supercomputers
Authors: Ohue Masahito , Shimoda Takehiro , Suzuki Shuji , Matsuzaki Yuri , Ishida Takashi , Akiyama Yutaka 
Published: August 2014

Abstract
Summary: The application of protein–protein docking in large-scale interactome analysis is a major challenge in structural bioinformatics and requires huge computing resources. In this work, we present MEGADOCK 4.0, an FFT-based docking software that makes extensive use of recent heterogeneous supercomputers and shows powerful, scalable performance of &gt;97% strong scaling.
Availability and Implementation: MEGADOCK 4.0 is written in C++ with OpenMPI and NVIDIA CUDA 5.0 (or later) and is freely available to all academic and non-profit users at: http://www.bi.cs.titech.ac.jp/megadock .
Contact: akiyama@cs.titech.ac.jp
Supplementary information: Supplementary data are available at Bioinformatics online