bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Pelatihan dan Pendidikan Dalam Meningkatkan Prestasi Kerja Pegawai Kantor Satpol PP Kabupaten Simalungun
Authors: Saragih Tumpak Mangoloi , Purba Djuli Sjafei 
Published: August 2024

Sumber daya manusia merupakan suatu aset yang sangat penting dimiliki oleh sebuah instansi atau organisasi. Hal ini karena faktor manusia yang berperan melaksanakan kegiatan untuk mencapai tujuan yang diinginkan oleh instansi tersebut. Berdasarkan penelitian yang telah dilakukan pada kantor Satpol PP Kabupaten Simalungun bahwa Pelatihan Dan Pendidikan berpengaruh besar terhadap Prestasi Kerja pegawai. Ini terlihat dari teknik analisis yang telah dilakukan yaitu dengan menggunakan sampel 40 responden dengan metode skala likert, data yang didapat dianalisa dengan menggunakan data yaitu Uji Instrumen dengan menggunakan Uji Validitas dan Uji Reabilitas, Uji Hipotesis yaitu dengan Analisis Regresi Linear berganda, Uji T, Uji F dan Analisis Koefisien Determinasi (R2). Persamaan regresi yaitu Y=2,072+0,324 X1 + 0,558X2. Ini menunjukkan nilai koefisien variabel Pelatihan positif sebesar 0,324 dan variabel Pendidikan positif sebesar 0,558, maka dapat disimpulkan Nilai r adalah 0,975 menunujukkan bahwa hubungan koefisien anatara Pelatihan Dan Pendidikan sangat kuat bahwa Pelatihan Dan Pendidikan mempunyai pengaruh positif terhadap Prestasi Kerja.Determinasi (R2) adalah 0,938. Hal ini menunjukkan bahwa sebesar 93,8% Pelatihan Dan Pendidikan dapat dijelaskan oleh variabel Prestasi Kerja, sedangkan sisanya (100% - 93,8 %= 6,2%) dijelaskan atau dipengaruhi oleh faktor-faktor lain yang tidak diteliti. Uji t dilakukan untuk mengetahui variabel-variabel bebas (Pelatihan Dan Pendidikan) terhadap variabel terikat (Prestasi Kerja) pada Kantor Satpol PP Kabupaten Simalungun. Dari uji thitung X1 sebesar mempunyai thitung yakni 8,244 dengan ttabel=1,6877. Variabel X2 mempuyai thitung yakni 10,105 dengan ttabel= 2,431. Jadi thitung>ttabel artinya terdapat pengaruh positif dan signifikan dari variabel bebas terhadap Prestasi Kerja
Penyajian Laporan Keuangan Entitas Berorientasi Non Laba Berdasarkan ISAK 35 Pada Gereja GMI Effatha
Authors: Purba Sahala , Manullang Novelita 
Published: August 2024

Penelitian ini membahas tentang penyajian keuangan laporan entitas nirlaba.Awalnya, nirlaba entitas menyajikan laporan keuangan berdasarkan PSAK 45 yang kemudian diubah menjadi ISAK 35.Satu dari entitas nirlaba yang termasuk dalam gereja, aspek yang paling penting adalah keuangan akuntabilitas.Akuntabilitas yang baik diperoleh dari standar akuntansi yang berlaku umum.Jurnal ini bertujuan untuk mengetahui penyajian laporan keuangan berdasarkan penerapan ISAK 35.Objek dari makalah ini adalah presentasi laporan keuangan Gereja GMI Effatha.Data dikumpulkan melalui serangkaian wawancara dan observasi. Keuangan pernyataan - pernyataan yang akan dihasilkan adalah pernyataan - pernyataan dari posisi keuangan, laporan komprehensif laba rugi, laporan arus kas dan catatan atas laporan keuangan
Influence of Entrepreneurship Knowledge on Employability of TVET Graduates in Tanzania: The Moderating Role of Self-Efficacy
Authors: Waziri Mahija , Ngaruko Deus , Ngatuni Proches 
Published: August 2024

This paper is based on the study aimed to examine the influence of entrepreneurship knowledge on employability among TVET graduates in Tanzania and the moderating role of Self-Efficacy. The study was guided by human capital and self-efficacy theories. An explanatory research design was employed, and data was collected using a structured questionnaire administered on a sample of 353 graduates from TVET institutions by a Kobo toolbox. Structural Equation Modelling was used for data analysis. The finding of the study revealed a positive and significant relationship between entrepreneurship knowledge and employability of graduates. Furthermore, a multi-group moderation analysis indicated that, the relationship was positive and significantly stronger in the group with high self-efficacy but it was insignificant relationship in the group with low self-efficacy. Therefore, the education policy makers, curriculum developers and TVET institutions in Tanzania should emphasize on programs that will improve graduates’ entrepreneurship knowledge such as recognizing business resources, financial resources, and use of technology in business, ability to target customers, understanding of tax laws and regulations in business as well as improving sales and creation of market plan. The study also concluded the effect on entrepreneurship knowledge on employability is improved when self-efficacy is increased, calling for measures to raise graduates’ self-efficacy
Prevalence of metabolic syndrome and its components among the teaching faculty of Allama Iqbal Medical College and Jinnah Hospital Lahore
Authors: Roomi Mudassar Ali , Kamran Haneen , Bilal Ahmad , Minhas Umm-e-Aimen , Tahira Sameen , Zafar Hafiz Muhammad Qasim 
Published: August 2024

BACKGROUND & OBJECTIVES: Metabolic syndrome and its components are established risk factors for type-2 diabetes mellitus and cardiovascular diseases. The Objectives of the current study were to assess the mean values of cardiometabolic risk factors and anthropometric parameters among the teaching faculty of Allama Iqbal Medical College and Jinnah Hospital Lahore (AIMC/JHL). To investigate the prevalence of metabolic syndrome and its components.
METHODOLOGY: This cross-sectional study was conducted from December 2022 to July 2023 at AIMC/JHL. Faculty members (n=115), aged 30-60, were recruited by convenience sampling from basic and clinical departments. Metabolic syndrome was defined by ATP-III criteria. Means of quantitative variables were compared by student t-test. Chi-square was used to determine associations between nominal variables.
RESULTS: Mean values of arterial blood pressure were significantly higher in males than females. Fasting hyperglycemia was present in 38.3% of participants. Decreased HDL, hypertriglyceridemia, hypertension, and central obesity were found in 65.2%, 24.3%, 34.8%, and 74.8% of participants, respectively. The prevalence of low HDL and central obesity was significantly higher among females; however, hypertriglyceridemia and hypertension were more prevalent among males. A significant correlation (r=0.241) was observed (p=0.009) between age and waist circumference. Pre-metabolic syndrome and metabolic syndrome were present in 38.3% and 43.5% of participants, respectively.
CONCLUSION: An alarmingly high prevalence of metabolic syndrome and its components was observed among healthcare professionals who endeavor to treat similar diseases. This irony underscores the need for increased awareness and routine screening of metabolic syndrome among healthcare professionals
Response of the intravenous versus oral antibiotic regimen in brucellosis bacteremia.
Authors: Dr. Imran Nazir  , Mohammed A Al-Matrafi  , Bashal Fozya Bashir , Aboelazm Dr. Ahmed Farouk , Dr. Waleed Amasaib Mohammed Ahmed  
Published: August 2024

BACKGROUND AND OBJECTIVE: More than 500,000 new cases are reported globally annually. The World Health Organization recommends doxycycline with rifampicin or an aminoglycoside for brucellosis bacteremia. Some experts prefer to use doxycycline and rifampicin. We aimed to observe the response rate of intravenous versus oral anti-brucella therapy regimens in brucellosis bacteremia patients and compare the frequency of side effects and complications in both groups.
METHODOLOGY: This observational study included adult brucellosis bacteremia patients treated in a hospital in Makkah, KSA for four years. According to the method of treatment (oral versus IV antibiotics), patients were grouped into two categories. Following the treatment, all these patients’ records were evaluated. The negative blood culture was the primary endpoint whereas complications and all-cause mortality were secondary endpoints. The chi-square test, Fisher's exact test, and Mann-Whitney U test were applied accordingly to analyze the two groups’ characteristics.
RESULTS: A total of 93 cases were enrolled, the majority were males i.e., 64 (68.8%); with a mean age group (44.33 ±19.22 years). In total, 37 (39.8%) of patients were given IV regimens and the remaining 56 (60.2%) of patients were given oral regimens. Follow-up negative blood culture after 4 weeks was 90.3% (n = 84). The recovery rate was 93.5% (n = 87). No death was reported over this period. No difference was observed (P-value 0.309) between the oral and IV treatment regimens regarding the blood culture negativity.
CONCLUSION: Oral doxycycline-rifampicin (DR) and IV gentamicin-doxycycline-rifampicin (GDR) regimens have similar response rates in bacteremia brucellosis.
Enhancing Safety Management in the Ghanaian Construction Industry: Evaluating the Role of UAV Implementation and Construction Managers Understanding
Authors: Mustapha Zakari , Akomah Benjamin Boahene , Kwaku Ofosu Emmanuel , Tieru Chris K. 
Published: August 2024

The integration of unmanned aerial vehicles (UAVs) and other rising technologies has become paramount in construction safety monitoring and management. The study aimed to gain insight into the use of drones in construction safety practices and management in the Ghanaian construction industry. Through a literature review, five key domains (aerial surveillance and real-time monitoring, data analysis and risk assessment, emergency response and search-and-rescue operations, information management and visualisation, and safety training and education) were identified as the areas where UAVs or drones could enhance safety practices and management. The study included construction professionals who had a minimum of ten (10) years of experience in project management across different positions. A convenience sampling technique was used for the selection of participants from construction companies within the city of Accra. A structured questionnaire was designed and distributed to these professionals. The collected data was analysed using descriptive statistics and correlation analysis. The correlation analysis highlights the association among the variables used. The study underscores the pivotal role of UAVs in transforming safety practices and management. The diverse applications and potential benefits of UAV technology provide insights for policymakers, educators, and industry stakeholders to optimise safety management strategies and enhance efficiency on construction sites. In addition, the findings emphasise the importance of education and training initiatives to bridge the knowledge gap among construction professionals, thereby promoting a more sustainable and secure construction environment in Ghana.
Newly Credentialed Athletic Trainers’ Onboarding Process During the Transition to Practice
Authors: Thrasher Ashley B. , Walker Stacy E. , Cavallario Julie M. 
Published: August 2024

Context
As new athletic trainers (ATs) transition into their roles, some employers provide orientation and onboarding to assist with the transition to practice. Research in which authors outline the ideal onboarding process for new ATs transitioning to practice is lacking.

Objective
To examine the onboarding process for new ATs.

Design
Grounded theory.

Setting
College or university, secondary school, and hospital or clinic.

Patients or Other Participants
Seventeen newly credentialed, employed ATs who recently graduated from professional masters’ programs (11 female, 6 male; 25.6 ± 2.2 years) and 12 employers (6 female, 6 male; years in role supervising new ATs: 8.5 ± 4.9) participated in this study.

Data Collection and Analysis
Participants were recruited via purposive sampling. Each participant was interviewed via phone using a semistructured interview guide. Employees were interviewed approximately 3, 6, 9, and 13–15 months after beginning employment. Employers were interviewed 1 time. Data saturation guided the number of participants. Data were analyzed through grounded theory, with data coded for common themes and subthemes. Trustworthiness was established via peer review, member checks, and multianalyst triangulation.

Results

Two themes emerged
initial orientation and continued onboarding. Participants reported receiving organizational, departmental, and site-specific orientations for initial orientation. For continued onboarding, participants reported mentoring, site visits, feedback and evaluation, regular meetings, and continuing education and professional development.

Conclusions
Onboarding is vital in transitioning to practice for newly credentialed ATs, as it provides support and helps new employees understand and adapt to their roles. Onboarding should go beyond initial orientation and include regular meetings with supervisors, other ATs, and site visits to provide feedback and ensure new ATs adapt to their roles. New ATs should seek support from supervisors and local ATs to help better understand their role.
Individual and Combined Effects of Sport-Related Concussion and Anterior Cruciate Ligament Injury on Neurocognitive and Neuromechanical Reaction Time
Authors: Moran Ryan N. , Grooms Dustin R. 
Published: August 2024

Context
Recent epidemiological data have indicated a potential connection between sport-related concussion (SRC) and elevated anterior cruciate ligament (ACL) injury risk. Limited research exists in which authors have quantified cognitive and motor outcome measures between SRC and ACL injury history.

Objective
To examine the individual and combined effects of a history of SRC and ACL injury and reconstruction (ACLR) on neurocognitive and neuromechanical function.

Design
Cross-sectional study.

Setting
Research laboratory.

Patients or Other Participants
Forty-seven recreationally active college individuals with either an injury history of SRC (n = 12), ACLR (n = 12), combination of SRC + ACLR (n = 11), or uninjured controls (n = 12).

Main Outcome Measure(s)
Participants completed a neurological battery using the C3 Logix application and TRAZER system for neuromechanical reaction time (RT). C3 Logix subtests consisted of the Trail Making Test (TMT) A, B, and B − A; simple and choice RT; and processing speed. TRAZER subtests consisted of simple, Flanker-task, and Stroop-task RT. Participants were categorized into 3 group comparisons of either (i) SRC, ACLR, SRC + ACLR, and controls, (ii) any or no SRC overall, or (iii) any or no ACLR overall.

Results
No differences were demonstrated between SRC, ACLR, SRC + ACLR, and controls on TMT (P = .07–.14), neurocognitive (P = .14–.93), or neuromechanical (P = .64–.99) performance. Those with any SRC had slower TMT B − A times (P = .03), while those with any ACLR had slower TMT A (P = .02) times than those with no ACLR. No differences were noted for the TRAZER simple, Flanker, or Stroop RT for any or no SRC and ACLR groups.

Conclusions
College students with a combined effect of SRC and ACLR did not differ from other groups on neurocognition and neuromechanical RT. Individuals with a history of SRC or ACLR had a worse TMT, leading to inquiry about potential long-term neurological deficits, despite no differences in those with a combined history.
Suicide Attempters Compared to Intentional Self-Harm Have a Severe Suicidal Intention and Poorer Reasons for Living Soon after Their Attempts: A Hospital-Based Cross-Sectional Study
Authors: Bhogaraju Anand , Anusha Korem , Gudlavallety Preethi 
Published: August 2024

Abstract

Background:
Suicidal intent after an attempt remains high, while in some studies, a cathartic effect was reported. Many subjects do not take adequate precautions despite a previous attempt.

Aims and Objectives:
To evaluate the severity of suicidal intent after an attempted suicide in comparison to intentional self-harm (ISH) soon after an attempt and assess activating and protective factors in both these conditions.

Materials and Methods:
In a tertiary hospital, soon after ISH or suicidal attempt (SA), cross-sectional data were collected on socio demographics, attempts, Beck’s suicidal intent scale, Columbia suicide severity rating scale, and brief reasons for living (BRL) scale and analyzed.

Results:
21 SAs and 16 ISH were identified. Mean of severe suicide intent in SA (29. 56) was higher than ISH (25.52). ISH had higher scores on impulsive behavior 17 (81%) than 10 SA (62.5%), better identification of protective factors in ISH 20 (95.2%) than 11 (68.8%) in SA group. Better recognition of social networks and support in ISH group 18 (85.7%) than suicide attempters 10 (47.6%). SA group had significant negative correlations between BIS and BRL on responsibility to family rho = −0.55, P = 0.03. Hopelessness and impulsivity showed no effect on suicidal intention on ANOVA.

Conclusions:
Assessment of suicidal intent is important soon after SA and ISH. In ISH, suicidal intent appears suppressed. Higher impulsiveness was seen in ISH group but was able to identify reasons for living better than SA group. Suicidal intent, impulsivity, and hopelessness appear to be independent factors of each other.
Isolation, purification and characterization of bioactive surfactant from the probiotic bacterium Lactobacillus casei NM512 isolated from infant microbiota
Authors: Zakaria Mohamed K. , Zaghloul Rashed A. , Tewfike Taha A. , Salem Ahmed A. , Mansour Nahla M. 
Published: August 2024

Background

Lactobacillus casei NM512 was previously isolated from the feces of breast-fed infants and has great potential for probiotic treatment of diseases that are based on immune deregulation. These strains fulfill the main criteria required for safe human consumption and could therefore be useful in pharmaceutical and therapeutic preparations. However, further studies are needed to evaluate and decipher the in vivo activities of the isolated strains with regard to their immunomodulatory function.

Objective
This work aims to isolate, identify and characterize the bioactive surfactant component from the probiotic bacterium L. casei NM512.

Materials and methods
The isolation of the surfactant from L. casei NM512 was performed after incubation the strain for 72 h at 37°C with shaking at 120 rpm. The surfactant extracted from cells by acid precipitation. A combination of different methods (TLC, FT-IR, NMR, and GC mass) was used to analyze the composition of the isolated surfactant. The surfactant was also investigated for its antimicrobial activity using the well agar diffusion method, antioxidant ability targeting the DPPH free radical, Cytotoxicity ability using MTT assay, and anti- inflammatory activity was done by determination the inhibition of nitric oxide (NO) production in RAW 264.7 macrophages.

Results and conclusion
The obtained data show that the surfactant is a mixture of carbohydrates, lipids and proteins with glycolipopeptide nature that expressed remarkable antibacterial and antioxidant activities. Furthermore the isolated surfactant showed safety by keeping the cell viability and anti-inflammatory activity. Here we introduce a novel biosurfactant for medical and pharmaceutical purposes.
Empirical and molecular docking-based screening of heterocyclic compounds to identify potential acetylcholinesterase inhibitors to treat Alzheimer’s disease and its histology
Authors: Alhuwaymil Zamzam , Mohammedsaleh Zuhair M. , Moawadh Mamdoh S. , Bassfar Zaid , Aggad Waheeb S. , Alkhudhairy Basal Sulaiman M. , Almohaimeed Hailah M. , Alosaimi Manal E. , Soliman Mona H. 
Published: August 2024

Background
Alzheimer’s disease (AD) is characterized by neuropathological symptoms, there has been no proper cure in recent era. It was linked to a deficiency in the brain neurotransmitter acetylcholine. Acetylcholinesterase is an enzyme that breaks down acetylcholine to an inactive form and the death of cholinergic neurons.

Objective
Therefore, there is a crucial need to identify alternative compounds with potential anti-cholinesterase agents and minimal undesirable effects. Fluoroquinolones and benzimidazole-benzothiazole derivatives offer antimicrobial, anti-inflammatory, anti-oxidant, anti-diabetic, and anti-Alzheimer activities.

Materials and methods
A series of fluoroquinolones and benzimidazole-benzothiazole derivatives were evaluated against acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE) enzymes. For this purpose, molecular docking and adsorption, distribution, metabolism, excretion, and toxicology ADMET models were used for in-silico studies in addition to in-vitro studies, Fluoroquinolones (Z, Z3, Z4, Z6, Z8, Z12, Z15, and Z9) and benzimidazole-benzothiazole compounds (TBIS-16, TBAF-1, TBAF-2, TBAF-3, TBAF-4, TBAF-5, TBAF-6, TBAF-7, TBAF-8, and TBAF-9) passed through the AChE inhibition assay and their IC50 values were calculated.

Results and conclusion
The compound 1-ethyl-6-fluoro-7-(4-(2-(4-nitrophenylamino)-2-oxoethyl)piperazin-1-yl) −4-oxo-1, 4 di-hydroquinoline-3-carboxylic acid and 2-((1H-benzo[d]imidazol-2-yl)methyl)-N’-(3-bromobenzyl)-4-hydroxy-2H-thiochromene-3-carbohydrazide 1, 1-dioxide (Z-9 and TBAF-6) showed the lowest IC50 values against AChE/BChE (0.37±0.02/2.93±0.03 μM and 0.638±0.001/1.31±0.01 μM, respectively) than the standard drug, donepezil (3.9±0.01/4.9±0.05 μM). During the in-vivo investigation, behavioral trials were performed to analyze the neuroprotective impact of Z-9 and TBAF-6 compounds on AD mouse models. Hematological and histopathological parameters revealed that compounds have a safer aptitude. However heterocyclic compounds dramatically corrected the loss of neurons, neuroinflammation, neurofibrillary tangles, and degenerative changes in the brain’s architecture. Also, Z-9 and TBAF-6 compounds improve behavioral and biochemical parameters hence treating neurodegenerative disorders effectively.
Effect of melatonin on oxidative stress of differentiated Dopaminergic cells
Authors: Ibrahim Hadeer A.M. , Hussein Abdelaziz M. , Gabr Mahmoud , A.F. Abdel –Aziz , El-Saeed Rasha A. 
Published: August 2024

Background
Although stem cells therapies provide a great deal in the treatment of several disease, they lack their normal functions after transplantation due to inflammation and oxidative stress. Melatonin has a powerful antioxidant ability and can enhance the effect of stem cells.

Objectives
This work aimed to investigate the melatonin’s effect on oxidative stress of differentiated adipose-mesenchymal stem cells (AD-MSCs) to dopaminergic (DAergic) cells.

Material and methods
The AD-MSCs cells were characterized after passage 3 by flow cytometry method and divided into four groups: (a) control group that was nontreated AD-MSCs, (b) MSCs+M group that was AD-MSCs cultured with 1 μM melatonin in expansion media for 12 days, (c) DN group that was MSCs treated with neurobasal A media for 12 days, (d) DN+M group which was MSCs cultured with 1 μM melatonin and neurobasal A media for 12 days. After 12 days, the catalase (CAT) activity and malondialdehyde (MDA) level were measured by using ELISA. Also, the gene expression level of MAP-2 was detected.

Results and conclusion
The current study proved that the isolated cells were MSCs due to high expression percentages for CD73 and CD90 and low expression percentages for CD34 and CD45. The DN+M group showed the highest expression of MAP-2 gene when compared to the other different groups (P ≤ 0.05). Moreover, there was a significant increase in CAT concentration in groups treated with melatonin than other group (P ≤ 0.05), while, there was no change in MDA level between all groups. It was concluded that melatonin has an effective antioxidative role throughout the differentiation process of AD-MSCs into DAergic neural cells