bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of blue-collar vs. white-collar occupations on disease burden in psoriatic arthritis patients: A Swiss clinical quality management in rheumatic diseases cohort study
Authors: Colla Nina , Maul Julia-Tatjana , Vallejo-Yagüe Enriqueta , Burden Andrea Michelle , Möller Burkhard , Nissen Michael J. , Yawalkar Nikhil , Papagiannoulis Eleftherios , Distler Oliver , Ciurea Adrian , Micheroli Raphael 
Published: August 2024

AbstractBiomechanical stress may exacerbate inflammation in psoriatic arthritis (PsA). This study aimed to investigate disease activity, work disability, and drug response/retention rates in PsA patients among two different occupation’s types: blue-collar workers (BCol) with manual labor versus white-collar workers (WCol) with sedentary occupations. PsA patients registered in the Swiss cohort (SCQM) were classified as BCol or WCol workers and assessed at the initiation of a biologic or targeted synthetic disease-modifying anti-rheumatic drug (b-/tsDMARD). We compared the baseline characteristics at treatment start and the DAS28-CRP for the 1-year remission. Treatment retention was investigated using Kaplan–Meier curves and Cox regression analysis. Multivariable models were adjusted for potential confounders. Of 564 patients, 29% were BCol, and 71% were WCol workers. Baseline disease activity was comparable between both groups. BCol workers were predominantly male (79.8%) and more work disabled at baseline (84.0% vs. 27.9%; p < 0.01). One hundred seventy-four treatment courses (TCs) of 165 PsA patients were included for longitudinal analysis. Occupation did not significantly influence the achievement of DAS28-CRP remission at 1 year. Kaplan–Meier analysis (n = 671) indicated longer retention for BCol workers (mean retention duration: 3.15 years vs. 2.15 years, (p = 0.006). However, adjusted Cox regression analysis did not corroborate these findings. This study indicates that physically demanding occupations correlate with increased rates of work disability among PsA patients, while treatment response seems to be unaffected by the patients’ occupation type. Additional research is required to thoroughly comprehend the relationship between physical workload, disease activity, and treatment outcomes.

Key Points• This study indicates that physically demanding occupations correlate with increased rates of work disability among PsA patients.• The treatment response among of PsA patients seems unaffected by the patients’ occupation type.
Sex-specific discrimination of familiar and unfamiliar mates in the Tokay gecko
Authors: Verger Marie-Ornélia , Devillebichot Maëlle , Ringler Eva , Szabo Birgit 
Published: August 2024

Abstract
Social animals need to keep track of other individuals in their group to be able to adjust their behaviour accordingly and facilitate group cohesion. This recognition ability varies across species and is influenced by cognitive capacities such as learning and memory. In reptiles, particularly Squamates (lizards, snakes, and worm lizards), chemical communication is pivotal for territoriality, reproduction, and other social interactions. However, the cognitive processes underlying these social interactions remain understudied. In our study, we examined the ability of male and female Tokay geckos (Gekko gecko) to chemically differentiate familiar and unfamiliar mating partners. Our findings suggest that both sexes can make this distinction, with males responding more to the odour of a familiar mate, and females responding more to unfamiliar mates. The lizards maintained their discriminatory abilities for two to three weeks but not up to six weeks after separation. This research highlights the efficacy of using odours as social stimuli for investigating social cognition in lizards, a promising avenue to better understand social cognition in these animals.
Clinical features and prognosis of prosthetic valve endocarditis due to Staphylococcus aureus
Authors: Diego-Yagüe Itziar , Ramos-Martínez Antonio , Muñoz Patricia , Martínez-Sellés Manuel , Machado Marina , de Alarcón Arístides , Miró José M. , Rodríguez-Gacía Raquel , Gutierrez-Díez José Francisco , Hidalgo-Tenorio Carmen , Loeches-Yagüe Belén , López-Azor Juan Carlos 
Published: August 2024

Abstract
Purpose
Staphylococcus aureus prosthetic valve endocarditis (SAPVE) is a serious infection with high mortality. The main objective of this study was to identify factors associated with in-hospital mortality.

Methods
From January 2008 to December 2021, consecutive patients from a Spanish cohort of infective endocarditis with a definitive diagnosis of SAPVE were analyzed.

Results
During the study period, 219 cases of definitive SAPVE were diagnosed, which accounted for 16.7% of a total of 1309 cases of definitive prosthetic valve endocarditis (PVE). Patients presented advanced age and marked comorbidity. There was a higher incidence of persistent bacteremia, septic shock, stroke, and acute kidney injury than in cases of PVE caused by other microorganisms. Methicillin resistance was not associated with differences in clinical presentation, echocardiographic findings, or mortality. Only 50.6% of the patients with surgical indications (88 patients) underwent surgery. Overall, in-hospital mortality was 47.9%. The variables associated with in-hospital mortality were age (OR:1.03, 95% CI: 1.00-1.05; p = 0.016), heart failure (OR:2.86, 95% CI: 1.53–5.32; p = 0.001), acute kidney injury (OR:2.42, 95%CI:1.28–4.58; p = 0.006), stroke (OR:3.53, 95%CI:1.79–6.96; p < 0.001) and surgery indicated but not performed (OR:2.01, 95%CI:1.06–3.8; p = 0.030). On the other hand, the performance of surgery per se in patients with SAPVE, regardless of whether there was a surgical indication according to the guidelines, was not associated with a reduction in in-hospital mortality.

Conclusions
SAPVE is characterized by high mortality, which is more marked in patients who present a surgical indication but do not undergo surgery.
Efficacy of robot-assisted partial nephrectomy compared to conventional laparoscopic partial nephrectomy for completely endophytic renal tumor: a multicenter, prospective study
Authors: Hinata Nobuyuki , Murakami Sae , Nakano Yuzo , Hara Isao , Kondo Tsunenori , Hamamoto Shuzo , Shiroki Ryoichi , Nagayama Jun , Kawakita Mutsushi , Eto Masatoshi , Ukimura Osamu , Takenaka Atsushi , Takagi Toshio , Shimbo Masaki , Azuma Haruhito , Yoshida Tetsuya , Furukawa Junya , Kawamorita Naoki , Fujisawa Masato 
Published: August 2024

Abstract
Background
This study aimed to compare the efficacy of robot-assisted partial nephrectomy for completely endophytic renal tumors with the reported outcomes of conventional laparoscopic partial nephrectomy and investigate the transition of renal function after robot-assisted partial nephrectomy.

Methods
We conducted a prospective, multicenter, single-arm, open-label trial across 17 academic centers in Japan. Patients with endophytic renal tumors classified as cT1, cN0, cM0 were included and underwent robot-assisted partial nephrectomy. We defined two primary outcomes to assess functional and oncological aspects of the procedure, which were represented by the warm ischemic time and positive surgical margin, respectively. Comparisons were made using control values previously reported in laparoscopic partial nephrectomy studies. In the historical control group, the warm ischemia time was 25.2, and the positive surgical margin was 13%.

Results
Our per-protocol analysis included 98 participants. The mean warm ischemic time was 20.3 min (99% confidence interval 18.3–22.3; p < 0.0001 vs. 25.2). None of the 98 participants had a positive surgical margin (99% confidence interval 0–5.3%; p < 0.0001 vs. 13.0%). The renal function ratio of eGFR before and after protocol treatment multiplied by splits was 0.70 (95% confidence interval: 0.66–0.75). Factors such as preoperative eGFR, resected weight, and warm ischemic time influenced the functional loss of the partially nephrectomized kidney after robot-assisted partial nephrectomy.

Conclusions
Robot-assisted partial nephrectomy for completely endophytic renal tumors offers a shorter warm ischemia time and comparable positive surgical margin rate compared with conventional laparoscopic partial nephrectomy.
The authenticity dilemma: towards a theory on the conditions and effects of authentic learning
Authors: Nachtigall Valentina , Shaffer David Williamson , Rummel Nikol 
Published: August 2024

AbstractA highly authentic learning setting is likely to trigger positive motivational and emotional reactions due to its emphasis on promoting the acquisition of knowledge that is connected and transferable to real-world phenomena outside the learning environment. However, a high level of authenticity is usually accompanied by a high level of complexity due to the complexity inherent in the real world. This complexity can be overwhelming for learners and can hamper or even prevent cognitive learning outcomes. Consequently, to help learners cope with this complexity, they need some kind of instructional support. By building a high level of support into the learning setting in order to promote cognitive learning outcomes, the level of authenticity and thereby the effects of authenticity on motivational outcomes may, however, in turn be reduced. In the present conceptual paper, we refer to this tension between authenticity and complexity, on the one hand, and instructional support, on the other hand, as the “authenticity dilemma”. Based on existing empirical evidence from previous studies, we (1) outline this dilemma, (2) discuss ways to reconceptualize it, and (3) derive implications regarding the conditions and effects of authentic learning. Finally, we discuss the findings of the studies included in the special issue “Perspectives on Authentic Learning” through the lens of the authenticity dilemma.
A Problem for Autonomous Know-How
Authors: Robertson Ian 
Published: August 2024

AbstractIn his recent Autonomous Knowledge monograph, J. Adam Carter develops a non-standard anti-intellectualist account of know-how. On this account, an agent manifesting know-how necessarily involves her exhibiting a particular kind of cognitive grasp of the mechanism by which she performs her action. Carter considers a potential problem for his new anti-intellectualism: namely, whether it precludes less cognitively sophisticated agents from knowing how. In this discussion piece, I argue that his attempts to assuage such concerns—by appeal to work by Duncan Pritchard—fails to address the problem.
Assessing the influence of sleep and sampling time on metabolites in oral fluid: implications for metabolomics studies
Authors: Scholz Michael , Steuer Andrea Eva , Dobay Akos , Landolt Hans-Peter , Kraemer Thomas 
Published: August 2024

Abstract
Introduction
The human salivary metabolome is a rich source of information for metabolomics studies. Among other influences, individual differences in sleep-wake history and time of day may affect the metabolome.

Objectives
We aimed to characterize the influence of a single night of sleep deprivation compared to sufficient sleep on the metabolites present in oral fluid and to assess the implications of sampling time points for the design of metabolomics studies.

Methods
Oral fluid specimens of 13 healthy young males were obtained in Salivette® devices at regular intervals in both a control condition (repeated 8-hour sleep) and a sleep deprivation condition (total sleep deprivation of 8 h, recovery sleep of 8 h) and their metabolic contents compared in a semi-targeted metabolomics approach.

Results
Analysis of variance results showed factor ‘time’ (i.e., sampling time point) representing the major influencer (median 9.24%, range 3.02–42.91%), surpassing the intervention of sleep deprivation (median 1.81%, range 0.19–12.46%). In addition, we found about 10% of all metabolic features to have significantly changed in at least one time point after a night of sleep deprivation when compared to 8 h of sleep.

Conclusion
The majority of significant alterations in metabolites’ abundances were found when sampled in the morning hours, which can lead to subsequent misinterpretations of experimental effects in metabolomics studies. Beyond applying a within-subject design with identical sample collection times, we highly recommend monitoring participants’ sleep-wake schedules prior to and during experiments, even if the study focus is not sleep-related (e.g., via actigraphy).
Survival and transfer potential of Salmonella enterica serovar Typhimurium colonising polyethylene microplastics in contaminated agricultural soils
Authors: Woodford Luke , Fellows Rosie , White Hannah L. , Ormsby Michael J. , Pow Chloe J. , Quilliam Richard S. 
Published: August 2024

AbstractAgricultural environments are becoming increasingly contaminated with plastic pollution. Plastics in the environment can also provide a unique habitat for microbial biofilm, termed the ‘plastisphere’, which can also support the persistence of human pathogens such as Salmonella. Human enteric Salmonella enterica serovar Typhimurium can enter agricultural environments via flooding or from irrigation with contaminated water. Using soil mesocosms we quantified the ability of S. Typhimurium to persist on microplastic beads in two agriculturally relevant soils, under ambient and repeat flood scenarios. S. Typhimurium persisted in the plastisphere for 35 days in both podzol and loamy soils; while during multiple flood events was able to survive in the plastisphere for up to 21 days. S. Typhimurium could dissociate from the plastisphere during flooding events and migrate through soil in leachate, and importantly could colonise new plastic particles in the soil, suggesting that plastic pollution in agricultural soils can aid S. Typhimurium persistence and facilitate further dissemination within the environment. The potential for increased survival of enteric human pathogens in agricultural and food production environments due to plastic contamination poses a significant public health risk, particularly in potato or root vegetable systems where there is the potential for direct contact with crops.
Performance evaluation of the nano-biodegradable drilling fluid using the greenly synthesized zinc nanorods and gundelia seed waste
Authors: Ali Jagar A. , Gailani Rayan , Abdullah Abdullah D. , Jaf Pshtiwan T. , Simo Sherwan Mohammed , Abdalqadir Mardin , Faris Vinos Mushir 
Published: August 2024

AbstractAddressing the increasing demand for green additives in drilling fluids is essential for the sustainable development of the oil and gas industry. Fluid loss into porous and permeable formations during drilling presents significant challenges. This study introduced an innovative, environmentally sustainable drilling fluid known as nano-biodegradable drilling fluid (NBDF). The NBDF formulation incorporates greenly synthesized zinc nanorods (ZNRs) and gundelia seed shell powder, with ZNRs derived from Cydonia oblonga plant extracts using an eco-friendly method. The research developed multiple drilling fluid variants for experimentation: a reference drilling fluid (BM); biodegradable drilling fluid (BDF) with particle sizes of 75, 150, 300, and 600 µm at concentrations ranging from 0.5 to 1 wt% (GSMs); a drilling nanofluid (DNF) with ZNRs at a 0.1 wt% concentration (ZNR); and NBDF combining both nano and gundelia waste (GS-ZNR). Experimental tests were conducted under various temperature and pressure conditions, including low temperature and low pressure (LTLP) and high temperature and high pressure (HTHP). Rheological and filtration measurements were performed to assess the impact of the nano-biodegradable additives on flow behavior and fluid loss. Results indicated that incorporating 1 wt% of gundelia seed shell powder with a particle size of 75 µm led to a 19.61% reduction in fluid loss compared to BM at 75 °C and 200 psi. The performance of the same GSM improved by 31% under identical conditions when 1 wt% of zinc ZNRs was added. Notably, the GS-ZNR formulation demonstrated the most effective performance in reducing fluid loss into the formation, decreasing mud cake thickness, and enhancing the flow behavior of the non-Newtonian reference drilling fluid. This study highlights the relevance of particle size in the effectiveness of biodegradable additives and underscores the potential of NBDF to address environmental concerns in the oil and gas drilling industry.
Undermining liberal international organizations from within: Evidence from the Parliamentary Assembly of the Council of Europe
Authors: Lipps Jana , Jacob Marc S. 
Published: August 2024

AbstractInternational organizations promoting democratic governance and human rights are increasingly challenged by some of their own member states. To better understand this dynamic, we propose a distinction between the illiberal ideology of political parties and their regime environment, aiming to examine the international behavior of actors extending beyond autocratic governments. We argue that the domestic regime environment plays a pivotal role in influencing the extent to which illiberal parties engage in contestation to undermine liberal norms on the international stage. We expect contestation behavior to be primarily driven by illiberal parties seeking to diminish the influence of liberal international politics on domestic power structures. Moreover, we contend that government participation moderates illiberal parties’ contestation behavior. To test our expectations empirically, we study roll call votes in the Parliamentary Assembly of the Council of Europe (PACE), one of the most powerful international parliaments promoting liberal values. Drawing on an original dataset that records approximately 500,000 individual votes cast in PACE decisions, we find evidence for substantive contestation by illiberal parties, especially those representing illiberal regimes. Only illiberal governments in liberal systems moderate themselves at the amendment stage. Our study has implications for the potential threat that emerging illiberal actors pose to international liberal institutions.
SEOM clinical guidelines on venous thromboembolism (VTE) and cancer (2023)
Authors: Morán Laura Ortega , Mateo Francisco José Pelegrín , Balanyà Rut Porta , Revuelta Jacobo Rogado , Martínez Silverio Ros , Fombella José Pablo Berros , Vázquez Elena María Brozos , Caro Natalia Luque , Langa José Muñoz , Fernández Mercedes Salgado 
Published: August 2024

AbstractThe Spanish Society of Medical Oncology (SEOM) last published clinical guidelines on venous thromboembolism (VTE) and cancer in 2019, with a partial update in 2020. In this new update to the guidelines, SEOM seeks to incorporate recent evidence, based on a critical review of the literature, to provide practical current recommendations for the prophylactic and therapeutic management of VTE in patients with cancer. Special clinical situations whose management and/or choice of currently recommended therapeutic options (low-molecular-weight heparins [LMWHs] or direct-acting oral anticoagulants [DOACs]) is controversial are included.
From Silence to Canvas: The Role of Artivism in Transforming Gender and Sexuality Norms
Authors: Christopher Ashitha Mary 
Published: August 2024

AbstractThis study delves into the uncharted scholarly intersection of art, LGBTQ + advocacy, and critical consciousness in India, to survey the current state of LGBTQ + artivism and explore how various artistic modalities operate their potential to transform gender and sexuality norms. It identifies LGBTQ + artivism as functioning primarily in two modes: the externalization of internal psychic states and the collective ingroup-outgroup engagement. The study observes that the transformative impacts of LGBTQ + artivism are often transient and rooted in affective responses; however, as possessing the potential to challenge normative ideologies and influence critical consciousness. Using Pierre Bourdieu’s framework, the study highlights that artivists function as ‘cultural intermediaries,’ employing various modalities that elicit different capacities for public involvement. Artworks that externalize internal psychic states, through mediums such as acrylic paintings and digital illustrations, are seen to facilitate the personal agency of LGBTQ + artists through the reimagination of the self amid societal discrimination of non-normativity. Additionally, collective and participatory artivism utilizes public platforms to foster dialogues that problematize the ‘us versus them’ dichotomy, both within and outside digital spaces. Through the lens of Bourdieu, the study also identifies digital LGBTQ + platforms as sites of ‘cultural consecration,’ offering inclusive alternatives to traditional gatekeeping in art production and dissemination.
Multicenter survey about leg length discrepancy and total hip arthroplasty: postoperative management
Authors: Stimolo D. , Lo Giudice S. , Matassi F. , Innocenti M. , Civinini R. , Boniforti F. 
Published: August 2024

Abstract
Background
We created a Multicenter Survey for Italian orthopedics surgeons on how they approach leg length discrepancy when dealing with primary total hip arthroplasty. Aim of the study was to show how surgeons manage LLD and follow literature recommendations during clinical practice.

Methods
The Survey was composed of 25 questions divided in 4 sections: surgeon’s profile, preoperative and intraoperative evaluation, postoperative management. In this paper, we report the absolute and relative frequencies of answers to section on “postoperative management.” Then, regarding the treatment of residual LLD, we reported whether trauma surgeons and experts in replacement surgery had higher odds ratios for providing “literature-based” answers compared to orthopedics physicians.

Results
Only four questions received more than 70% agreement on one of the answers. The OR for giving the “literature-based” answer, taking OP as the reference group was 1.57 for TR and 1.72 for RS for 10 mm LLD at first follow-up (FU) and 1.23 TR and 1.32 RS when 20 mm. When 10 mm LLD at 3 months FU the OR was 0.88 TR and 1.15 RS. The OR for treatment of LLD after the first examination of a new patient was 2.16 TR and 1.85 RS.

Conclusions
LLD is a debated topic with no definitive recommendations. Many decisions still depend on tradition. Treatment of LLD during clinical practice often differs from literature recommendations.