bluuebunny/crossref_metadata_2025_split huggingface dataset:
Canada’s Medical Assistance in Dying System can Enable Healthcare Serial Killing
Authors: Lyon Christopher 
Published: August 2024

Abstract
The Canadian approach to assisted dying, Medical Assistance in Dying (MAiD), as of early 2024, is assessed for its ability to protect patients from criminal healthcare serial killing (HSK) to evaluate the strength of its safeguards. MAiD occurs through euthanasia or self-administered assisted suicide (EAS) and is legal or considered in many countries and jurisdictions. Clinicians involved in HSK typically target patients with the same clinical features as MAiD-eligible patients. They may draw on similar rationales, e.g., to end perceived patient suffering and provide pleasure for the clinician. HSK can remain undetected or unconfirmed for considerable periods owing to a lack of staff background checks, poor surveillance and oversight, and a failure by authorities to act on concerns from colleagues, patients, or witnesses. The Canadian MAiD system, effectively euthanasia-based, has similar features with added opportunities for killing afforded by clinicians’ exemption from criminal culpability for homicide and assisted suicide offences amid broad patient eligibility criteria. An assessment of the Canadian model offers insights for enhancing safeguards and detecting abuses in there and other jurisdictions with or considering legal EAS. Short of an unlikely recriminalization of EAS, better clinical safeguarding measures, standards, vetting and training of those involved in MAiD, and a radical restructuring of its oversight and delivery can help mitigate the possibility of abuses in a system mandated to accommodate homicidal clinicians.
Developmental Impacts of Early Sensory Patterns on School-Age Adaptive, Maladaptive, and Participation Outcomes in Autistic and Non-autistic Children
Authors: Chen Yun-Ju , Sideris John , Watson Linda R. , Crais Elizabeth R. , Baranek Grace T. 
Published: August 2024

AbstractEarly sensory differences may cascade into later social-communication difficulties in autism, yet their impacts on broader functional outcomes have remained understudied. This study aimed to conduct a comprehensive investigation into the longitudinal impacts of sensory patterns, including sensory hyperresponsiveness, hyporesponsiveness, and sensory repetitions/seeking behavior, on various school-age outcome domains among a community sample of children with autistic and non-autistic conditions. We prospectively followed 1,517 children with caregiver-reported sensory questionnaires across three timepoints from infancy to school age. A subsample (n = 389; 88 with reported autism diagnosis/concerns) was further assessed with adaptive, maladaptive and participation outcome measures at age 6–7. Structural equation modeling approaches were used to evaluate the multivariate associations between latent growth parameters (i.e., intercepts and slopes) of sensory patterns and school-age outcomes. Increasing sensory hyperresponsiveness was directly associated with poorer adaptive/maladaptive outcomes and indirectly with lower participation in activities with higher functional demands across settings at school age. Elevated sensory hyporesponsiveness was associated with lower adaptive functioning, more externalizing problems, and lower classroom participation. Trajectories of sensory patterns accounted for more unique variances in adaptive functioning and participation in daily life settings with higher functional and environmental demands among autistic children compared to their non-autistic peers.
Systematic Assessment of Gambling Type Involvement: Reliability and Validity of the Gambling Disorder Identification Test (GDIT)
Authors: Wall Håkan , Wennberg Peter , Binde Per , Molander Olof 
Published: August 2024

Abstract
Gambling type involvement, both in terms of participation (engagement in specific gambling types) and diversity (how many gambling types an individual engages in), is a key feature to address in gambling self-report measures, but such systematic measurement procedures are scarce. The aim of this study was to test the psychometric performance of the gambling type assessment in the recently developed Gambling Disorder Identification Test (GDIT), in terms of test-retest reliability, convergent validity, and patterns of gambling diversity, among help-seeking and general population gambling samples (total n = 603). Overall, online gambling was more commonly reported as problematic than land-based gambling. Retest reliability varied for specific gambling types (ICC range 0.32–0.64, rtet range 0.66–0.85). In terms of gambling participation, online gambling showed stronger correlations with GDIT total score (i.e., symptom severity) than land-based gambling, where Slots showed the strongest correlation (r = 0.52), followed by Casino table games (r = 0.25), Sports and Horse betting (r = 0.16 and r = 0.14, respectively), and Poker (r = 0.14). Lotteries showed no correlation with GDIT total score (r=-0,01). For Slots gambling, all gambling diversity levels (including Slots as a single gambling type) were on average associated with the highest diagnostic severity level (GDIT total score > 30; severe gambling disorder). Finally, explorative configural frequency analysis identified typical and antitypical gambling diversity patterns. The result from the current study corroborates findings that engagement in specific gambling types matter, and that such features should be included in gambling measurement. We conclude that the GDIT is a reliable and valid measure for systematic assessment of gambling type involvement. The GDIT can be used to assess gambling participation and diversity, as part of a broad measurement setup for problem gambling and gambling disorder.
Investigation of the Impact of the H310A FcRn Region Mutation on 89Zr-Immuno-PET Brain Imaging with a BBB-Shuttle Anti‑Amyloid Beta Antibody
Authors: Wuensche Thomas E. , Stergiou Natascha , Mes Iris , Verlaan Mariska , Kooijman Esther J. M. , Windhorst Albert D. , Jensen Allan , Asuni Ayodeji A. , Bang-Andersen Benny , van Dongen Guus A. M. S. , Vugts Danielle J. , Beaino Wissam 
Published: August 2024

Abstract
Purpose
In the emerging field of antibody treatments for neurodegenerative diseases, reliable tools are needed to evaluate new therapeutics, diagnose and select patients, monitor disease progression, and assess therapy response. Immuno-PET combines the high affinity and exceptional specificity of monoclonal antibodies with the non-invasive imaging technique positron emission tomography (PET). Its application in neurodegenerative disease brain imaging has been limited due to the marginal uptake across the blood–brain barrier (BBB). The emergence of BBB-shuttle antibodies with enhanced uptake across the BBB extended immuno-PET to brain imaging. We recently reported about specific brain uptake of a bispecific aducanumab mTfR antibody in APP/PS1 TG mice using 89Zr-immuno-PET. However, a sufficient target-to-background ratio was reached at a relatively late scanning time point of 7 days post-injection. To investigate if a better target-to-background ratio could be achieved earlier, an aducanumab BBB-shuttle with a mutated Fc region for reduced FcRn affinity was evaluated.

Procedures
AduH310A-8D3 and Adu-8D3 were modified with DFO*-NCS and subsequently radiolabeled with 89Zr. The potential influence of the H310A mutation, modification with DFO*-NCS, and subsequent radiolabeling on the in vitro binding to amyloid-beta and mTfR1 was investigated via amyloid-beta peptide ELISA and FACS analysis using mTfR1 transfected CHO-S cells. Blood kinetics, brain uptake, in vivo PET imaging and target engagement of radiolabeled AduH310A-8D3 were evaluated and compared to non-mutated Adu-8D3 in APP/PS1 TG mice and wild-type animals as controls.

Results
Radiolabeling was performed with sufficient radiochemical yields and radiochemical purity. In vitro binding to amyloid-beta and mTfR1 showed no impairment. [89Zr]Zr-AduH310A-8D3 showed faster blood clearance and earlier differentiation of amyloid-beta-related brain uptake compared to [89Zr]Zr-Adu-8D3. However, only half of the brain uptake was observed for [89Zr]Zr-AduH310A-8D3.

Conclusions
Although a faster blood clearance of AduH310A-8D3 was observed, it was concluded that no beneficial effects for 89Zr-immuno-PET imaging of brain uptake were obtained.

Graphical Abstract
Blood Lipoproteins Shape the Phenotype and Lipid Content of Early Atherosclerotic Lesion Macrophages: A Dual-Structured Mathematical Model
Authors: Chambers Keith L. , Myerscough Mary R. , Watson Michael G. , Byrne Helen M. 
Published: August 2024

AbstractMacrophages in atherosclerotic lesions exhibit a spectrum of behaviours or phenotypes. The phenotypic distribution of monocyte-derived macrophages (MDMs), its correlation with MDM lipid content, and relation to blood lipoprotein densities are not well understood. Of particular interest is the balance between low density lipoproteins (LDL) and high density lipoproteins (HDL), which carry bad and good cholesterol respectively. To address these issues, we have developed a mathematical model for early atherosclerosis in which the MDM population is structured by phenotype and lipid content. The model admits a simpler, closed subsystem whose analysis shows how lesion composition becomes more pathological as the blood density of LDL increases relative to the HDL capacity. We use asymptotic analysis to derive a power-law relationship between MDM phenotype and lipid content at steady-state. This relationship enables us to understand why, for example, lipid-laden MDMs have a more inflammatory phenotype than lipid-poor MDMs when blood LDL lipid density greatly exceeds HDL capacity. We show further that the MDM phenotype distribution always attains a local maximum, while the lipid content distribution may be unimodal, adopt a quasi-uniform profile or decrease monotonically. Pathological lesions exhibit a local maximum in both the phenotype and lipid content MDM distributions, with the maximum at an inflammatory phenotype and near the lipid content capacity respectively. These results illustrate how macrophage heterogeneity arises in early atherosclerosis and provide a framework for future model validation through comparison with single-cell RNA sequencing data.
Modality redundancy for MRI-based glioblastoma segmentation
Authors: De Sutter Selene , Wuts Joris , Geens Wietse , Vanbinst Anne-Marie , Duerinck Johnny , Vandemeulebroucke Jef 
Published: August 2024

Abstract
Purpose
Automated glioblastoma segmentation from magnetic resonance imaging is generally performed on a four-modality input, including T1, contrast T1, T2 and FLAIR. We hypothesize that information redundancy is present within these image combinations, which can possibly reduce a model’s performance. Moreover, for clinical applications, the risk of encountering missing data rises as the number of required input modalities increases. Therefore, this study aimed to explore the relevance and influence of the different modalities used for MRI-based glioblastoma segmentation.

Methods
After the training of multiple segmentation models based on nnU-Net and SwinUNETR architectures, differing only in their amount and combinations of input modalities, each model was evaluated with regard to segmentation accuracy and epistemic uncertainty.

Results
Results show that T1CE-based segmentation (for enhanced tumor and tumor core) and T1CE-FLAIR-based segmentation (for whole tumor and overall segmentation) can reach segmentation accuracies comparable to the full-input version. Notably, the highest segmentation accuracy for nnU-Net was found for a three-input configuration of T1CE-FLAIR-T1, suggesting the confounding effect of redundant input modalities. The SwinUNETR architecture appears to suffer less from this, where said three-input and the full-input model yielded statistically equal results.

Conclusion
The T1CE-FLAIR-based model can therefore be considered as a minimal-input alternative to the full-input configuration. Addition of modalities beyond this does not statistically improve and can even deteriorate accuracy, but does lower the segmentation uncertainty.
Harmfulness and biological characters of a leaf beetle Gastrolina depressa (Coleoptera: Chrysomelidae) to its host plant Pterocarya stenoptera (Fagales: Juglandaceae)
Authors: Yun Wei , Li Li , Qingxiu Lin , Ying Huang , Ximing Zhang 
Published: August 2024

AbstractGastrolina depressa (Coleoptera: Chrysomelidae) has been found to damage many walnut plants in China. It prefers to feed on the annual leaves of an important economic plant, Pterocarya stenoptera (Fagales: Juglandaceae), and causes extensive cosmetic destruction, even plant death. Nevertheless, its biological characteristics are mostly unknown. In this study, we investigate the harmful and biological characteristics of G. depressa with different developmental stages. The results showed that G. depressa had four developmental stages: egg, larva (1st -3rd instar), pupa, and adult, the life history lasted nine days, with obvious overlapping generations. The food intake of the larvae increased with the increase of the instar, and the maximum food intake of the 3rd instar larvae was 448.19 mm2. The abdomen of the females was enlarged before oviposition, and the average number of eggs laid was 47.63 ± 13.53. Bioassay showed that there was no difference in the search time for the young (2.03, 1.25, 1.15, and 0.91 min) and old leaves (1.68, 1.15, 0.90, and 1.93 min) of P. stenoptera between 1st -3rd instar larvae and adults; the feeding preference of 1st -3rd instar larvae and adults for young leaves was higher than that to old leaves (23.33%, 26.67%, 33.33%, and 21.67%, respectively). The successful selection rates of 1st -3rd instar larvae and adults to young leaves (81.67%, 80%, 85.00%, and 70.00%, respectively) was higher than to old leaves (8.35%, 11.67%, 3.34%, and 11.67%, respectively).
Exploring Transgender and Non-Binary Engagement with Sex Tech: A Narrative Review
Authors: Anzani A. , Rucco D. , Prunas A. 
Published: August 2024

Abstract
Purpose of Review
This narrative review aims to explore the intersection of transgender and non-binary (TNB) sexuality with sex technology (sex tech), focusing on recent literature. The review is based on the analysis of 19 articles, including 6 specific to the TNB population and 13 that do not exclusively focus on this group. We sought to investigate how TNB individuals engage with various forms of sex tech, including pornography, sex dolls, sex robots, dating apps, sex toys, and virtual reality sex. We also aim to briefly delve into the representation of trans bodies and sexualities within the realm of sex tech.

Recent Findings
Recent research highlights the complexity of TNB individuals' engagement with sex tech. Studies indicate a growing interest in trans pornography, the prevalence of sex toy usage among TNB populations, and the emergence of dating apps specifically catering to TNB individuals. However, there remains a lack of empirical evidence regarding the experiences of TNB individuals with sex dolls, sex robots, and virtual reality sex.

Summary
Our examination underscores the need for more inclusive research on TNB sexuality within the sex tech discourse. While we have gained some insights, there are still gaps, especially in understanding how emerging technologies impact TNB individuals. Future research should prioritize exploring the motivations, experiences, and effects of sex tech on TNB individuals, while also ensuring ethical considerations and promoting diversity and inclusion in technological design and representation.
Evaluating two implant designs in patients undergoing primary total knee arthroplasty using a novel measure of early optimal recovery: a retrospective observational study
Authors: van Keulen L. Z. , Sonnega R. J. A. , Baas N. R. A. , Hogervorst T. , Muehlendyck C. , Bourras P. , ten Kate T. A. J. , Galvain T. , Dieleman S. , van Kampen P. M. 
Published: August 2024

Abstract
Purpose
Quality of care in total knee arthroplasty (TKA) between implants was assessed using a novel composite outcome measure, early optimal recovery (EOR), to indicate ideal clinical outcomes and minimal healthcare resource utilization.

Methods
Patients that underwent primary TKA in the study group (ATTUNE® Knee System) or control group (LCS® COMPLETE Knee System) were included in this retrospective, single-center study. EOR was defined as no complications, no readmissions, no extra outpatient visits, ≤ 48 h length of hospital stay (LOS), and restored range of motion and pain perception at 3-month follow-up. Multivariate logistic regression was used to compare EOR between the study and control groups. Results were adjusted for differences in baseline characteristics and are presented with 95% confidence intervals (CI). Data were collected from a specialized clinic for elective surgeries in the Netherlands, between January 2017 and December 2020.

Results
A total of 566 patients (62.4% female, mean age 67 years) were included for analysis; 185 patients (32.7%) underwent TKA in the study group. Compared to the control group, patients in the study group had greater probability of achieving EOR (65.8% [95% CI: 55.1–75.2] vs. 38.9% [95% CI: 32.8–45.3]; p < 0.001), a LOS ≤ 48 h (77.2% [95% CI: 67.7–84.5] vs. 61.4% [95% CI: 54.7–67.7]; p < 0.05), and ideal pain perception at 3-month follow-up (93.3% [95% CI: 85.7–97.0] vs. 78.2% [95% CI: 71.0–83.9]; p < 0.05).

Conclusion
The study group was associated with a greater probability of achieving EOR versus the control group, suggesting improved quality of care.
Some Generalizations of Dynamic Hardy-Knopp-Type Inequalities on Time Scales
Authors: El-Deeb Ahmed A. 
Published: August 2024

AbstractIn the present paper, some new generalizations of dynamic inequalities of Hardy-type in two variables on time scales are established. The integral and discrete Hardy-type inequalities that are given as special cases of main results are original. The main results are proved by using the dynamic Jensen inequality and the Fubini theorem on time scales.
Ervaringen en klantkenmerken van Boeren voor Buren
Authors: van der Velde Laura A. , Nieuwenhuijse Emma A. , Viaene Laura , van der Graaf Julia J. , Calis Stephanie , Hoekstra Trynke , Dijkstra Coosje 
Published: August 2024

Samenvatting
Inleiding
Stichting Boeren voor Buren (BvB) is een initiatief dat groente, fruit en kruiden aanbiedt tegen een lage prijs voor mensen met een laag inkomen. Ons onderzoek richt zich op de volgende vragen: wat zijn de karakteristieken, financiële status, en ervaren voedselzekerheid, gezondheid, welzijn en groente- en fruitinname van BvB-klanten? Wat is de ervaren invloed van het gebruik van BvB op groente- en fruitinname? Wat zijn redenen voor gebruik en ervaringen met het gebruik van BvB?

Methoden
Het betreft een mixed-methods crosssectioneel onderzoek. Er werden interviews en vragenlijsten afgenomen onder klanten van BvB met vragen over karakteristieken, financiële status, en ervaren voedselzekerheid, gezondheid en welzijn en groente- en fruitinname, alsmede redenen voor het gebruik van BvB en ervaringen met het gebruik ervan.

Resultaten en conclusie
In totaal werden 129 vragenlijsten ingevuld en 8 interviews afgenomen. De resultaten laten zien dat BvB een gemengde doelgroep bereikt: mensen met een laag inkomen en ervaren voedselonzekerheid, maar ook met relatief vaak een hbo-/universitaire opleiding en een hoge groente- en fruitinname. Deelnemers hadden minder vaak overgewicht dan de algemene bevolking, maar wel even vaak chronische aandoeningen. BvB wordt over het algemeen goed gewaardeerd door klanten. Een hoge groente- en fruitinname kan een reden zijn om klant van BvB te worden, maar er lijkt voor een deel van de klanten ook een extra positieve invloed te bestaan van BvB op de groente- en fruitinname.
Control of Mal secco disease in lemon by drip irrigation with fungicide
Authors: Ezra David , Ovadia Amos 
Published: August 2024

AbstractMal secco disease of citrus is caused by the mitosporic ascomycete fungus Plenodomus tracheiphilus (formerly Phoma tracheiphila [Petri]). Mal secco is a highly destructive vascular disease of lemon and other citrus which is presently confined to the Mediterranean basin and has a marked economic impact on the citrus industry. The fungal pathogen infects the host tree by penetrating through wounds in the roots or canopy. Infection spreads quickly into the main branches and trunk and tree mortality usually ensues. The most typical symptoms are veinal chlorosis, leaf wilt, red discoloration of the xylem and dieback of twigs and branches. Current accepted control of the disease is mainly by sanitation of infected wood, and copper application during the winter to prevent germinating spores from infecting the plant. No effective chemical control for this disease has been reported. We present a drip-irrigation protocol to protect trees and control the disease in which we apply 250 g/ha of the triazole fungicide flutriafol five times a year. Progression of disease symptoms in the treated trees was inhibited by up to 81% compared to the untreated control, thereby significantly shortening the sanitation process and making it less costly than in untreated trees. Moreover, disease symptoms became less severe as the duration of treatment increased. We have treated orchards for 3 years, and present an effective commercial protocol for the growers which will help them control Mal secco disease.
Reflections in waterholes: Reconceptualising young Indigenous Australian success
Authors: Harry Matilda , Trudgett Michelle , Page Susan , Grace Rebekah 
Published: August 2024

AbstractWhile there is a body of literature monitoring Indigenous Australian post-secondary school experiences, research investigating aspirational development in this life stage and Indigenous youth success as defined by Indigenous youth is severely lacking. Too often academic, government and public discourses portray Indigenous youth experiences through deficit frames of representation, completion and performance. By sharing the insights, reflections and aspirations of 15 young Indigenous Australian participants this paper calls for Indigeneity to be centred in ideations and indicators of Indigenous youth success. Findings confront institutionalised and hierarchical ideals of Indigenous Australian success premised on dominant neoliberal ideation and the accumulation of White cultural and social capital. Through an Indigenist Research lens this paper presents aspirational development and achievement as a complex and raced space where Indigenous Australian secondary school leavers articulate ambition and agency in developing successful careers, rich in cultural wealth and with their identity intact.