bluuebunny/crossref_metadata_2025_split huggingface dataset:
Partial Unilateral Lentiginosis Associated with Segmental Neurofibromatosis
Authors: Lee Won Soo , Yoo Min Seok , Ahn Sung Ku , Won Jin Hyung 
Published: April 2015

AbstractPartial unilateral lentiginosis associated with segmental neurofibromatosis is rare. Therefore, we describe here a patient with partial unilateral lentiginosis associated with ipsilateral segmental neurofibromatosis who developed multiple, rice‐sized, brown macules on the right side of her face, trunk, and upper arm and several bean‐sized, café‐au‐lait spots on the right upper arm and right upper back. To our knowledge, partial unilateral lentiginosis associated with ipsilateral segmental neurofibromatosis has not been reported in the English literature.
Drug Related Involvement of Specific Sites in Fixed Eruptions: A Statistical Evaluation
Authors: Sharma Vinod K. , Dhar Sandipan , Gill Amar Nath 
Published: April 2015

AbstractDifferent drugs produce fixed eruptions over different parts of the body. However, the significance of preferential site involvement in fixed eruptions due to specific drugs has not been statistically evaluated. One hundred and twenty five patients of fixed drug eruption (FDE) were studied to examine this question.Different sites affected by individual drugs were classified as lips alone, genitalia alone, lips and genitalia together, trunk alone, trunk and limbs together, and generalized. Statistical analysis was carried out for 7 common drugs causing FDE in 5 or more patients.Cotrimoxazole, a combination of sulfamethoxazole and trimethoprim, was the most common offender for FDE (32.8%), followed by analgin (12%), tetracycline (8%), pyrazolones (8%), metronidazole (6.4%), ciprofloxacin (5.6%), and phenytoin sodium (4%). Major sites involved by FDE were trunk and limbs (24%), lips alone (20.8%), genitalia alone (20%), generalised (14.4%), lips and genitalia together (11.2%), and trunk alone (8.8%). Seventy‐two (57.6%) patients had multiple lesions; 33 (42.4%) had single lesions. Involvement of mucocutaneous junctions of lips and genitalia by FDE was frequently caused by cotrimoxazole and tetracycline; trunk and limbs, by analgin and pyrazolones. Generalised eruptions were commonly caused by cotrimoxazole and phenytoin.The present statistical analysis confirms the clinical impression that genitalia alone are frequently involved in FDE due to tetracyclines (p<0.001). FDE over trunk and limbs was significantly associated with analgin (p<0.001), and generalised eruptions, with phenytoin sodium (p<0.001). The association of FDE over lips with cotrimoxazole was statistically not significant.
Pemphigus Vulgaris Exacerbated by Exposure to Sunlight
Authors: Muramatsu Tsutomu , Iida Takashi , Ko Toshiko , Shirai Toshihiko 
Published: April 2015

AbstractWe report two cases of pemphigus vulgaris who showed exacerbation of their bullous skin lesions after exposure to sunlight These cases indicate that ultraviolet light is an aggravating factor, not only for pemphigus foliaceus, but also for pemphigus vulgaris.
A Comparative Study of the Therapeutic Effect of Probucol and Pravastatin on Xanthelasma
Authors: Fujita Masaru , Shirai Kohji 
Published: April 2015

AbstractWe examined and compared the effects of probucol and pravastatin on the regression of xanthelasma. Thirty‐six cases treated by probucol and 18 cases by pravastatin were evaluated for 12 months. Thirteen of the 36 cases treated with probucol showed regression of xanthelasma. However, one of the 18 cases treated with pravastatin showed regression. These data were statistically significant. The average total cholesterol value in both groups decreased during drug therapy. However, the average of HDL‐cholesterol values in the probucol treatment group showed significant decreases, but those in the pravastatin treatment group did not. We discussed the mechanisms of the two drugs on the regression of xanthelasma and the mechanisms of development of xanthelasma.
A Case of Bednar Tumor Recurring after 23 Years
Authors: Mochizuki Yoshiko , Narisaw Yutaka , Kohd Hiromu 
Published: April 2015

AbstractWe reported a patient with a Bednar tumor who developed local recurrence 23 years later. The recurrent Bednar tumor showed the histopathological features of dermatofibrosarcoma protuberans (DFSP), and expressed CD34. We favor the term “Bednar tumor” rather than pigmented DFSP and consider that Bednar tumor is an intermediate type between cellular blue nevus and DFSP.
Chronic White Plaque of the Vulva in Postmenopausal Women
Authors: Inazumi Toyoko , Tajima Shingo 
Published: April 2015

AbstractWe report 13 cases of white lesions of the vulva in postmenopausal women. Nine cases had clinical and histological features typical of lichen sclerosus et atrophicus (LSA). Two cases exhibited mild histological changes suggestive of LSA. Two cases had normal‐appearing histology without significant histological changes. Considering the relatively short duration of the disease and relatively small lesions in the last two cases, they may be considered to represent the initial stage of LSA.
Lymphedema Due to Chronic Penile Strangulation: A Case Report
Authors: Tanabe Noboru , Muya Munenobu , Isonokami Masaaki , Kozuka Takehito , Honda Tomohito , Ohtani Hiroshi 
Published: April 2015

AbstractA 62‐year‐old man was admitted with swelling of the penis caused by long term use of a penis enlarging ring. For the previous 20 years, he had noticed small pruritic nodules on his penis. He had no micturitional or ejaculatory impairment.The penis had a diameter of 6 cm, a length of 10 cm, and was covered with thickened skin. The penis and the scrotal skin were covered with scattered, small, hemispheric nodules and papules ranging in size from 2 mm to 1 cm.Pathologic examination of the biopsied specimen from a nodule revealed enlargement of the lymphatic vessels of the dermis and fibrosis. This was compatible with lymphedema due to chronic strangulation by the ring.Scar resection and full thickness skin grafting was performed to prevent malignant changes in the lesions.
Selective Expansions of T cells Expressing Vβ38 and Vβ13 in Skin Lesions of Patients with Chronic Cutaneous Lupus Erythematosus
Authors: Furukawa Fukumi , Tokura Yoshiki , Matsushita Kayo , Iwasaki‐Inuzuka Kayoko , Onagi‐Suzuki Kazue , Yagi Hiroaki , Wakita Hisashi , Takigawa Masahiro 
Published: April 2015

AbstractThere are several clinical types of cutaneous lupus erythematosus (LE), including acute cutaneous LE (ACLE), which occurs in 50–60% of patients with systemic LE (SLE), chronic cutaneous LE (CCLE), which is almost the same as discoid LE (DLE), and subacute cutaneous LE (SCLE). Although several important hypotheses have been proposed to explain cutaneous LE, the pathomechanisms still remain complicated and obscure. Of special interest is whether and how the T cell receptor (TCR) repertoire of infiltrating lymphocytes is involved in the development of the different types. To address this issue, we immunohistochemically examined the Vβ usage of infiltrating T cells in skin lesions, as well as in peripheral blood mononuclear cells (PBMC) of patients with cutaneous LE. The number of Vβ3.1 CD3+ cells in the PBMC of patients with ACLE and CCLE was significantly lower than in controls. In contrast, the number of Vβ3.1 CD3+ cells was elevated in the skin lesion of CCLE over that in psoriasis vulgaris or atopic dermatitis. Furthermore, skin lesions in CCLE patients showed a higher incidence of Vβ8.1 CD3+ and Vβ13.3 CD3+ cells than did those in ACLE patients. These results suggest that skin lesions of CCLE are oligoclonally associated with selective expansions of TCR Vβ chains and may be induced by antigen stimuli, including superantigens.
A Case of Sézary Syndrome Associated with Cutaneous Transformation
Authors: Sakai Hiroyuki , Matsuo Shinobu , Matsumoto Mitsuhiro , Iizuka Hajime 
Published: April 2015

AbstractSézary syndrome is a leukemic variant in the spectrum of cutaneous T cell lymphomas. In some cases of cutaneous T cell lymphoma, the skin tumors or lymph nodes show morphologic changes indistinguishable from those of a large‐cell lymphoma; this has been termed transformation. We report a case of Sézary syndrome who developed multiple skin tumors that showed transformation, loss of multiple pan T‐cell markers (CD3, 4, 5, 7, 8), and a concomitant expression of CD30 during the course of the disease. Some of the tumors spontaneously regressed following incisional biopsy or traumatic wounds. The patient died of pneumonia five years following the transformation.
Lichen Striatus in an Adult
Authors: Mitsuhashi Yoshihiko , Kondo Shigeo 
Published: April 2015

AbstractA 58‐year‐old Japanese woman with lichen striatus had asymptomatic multiple erythemato‐papular plaques in arranged linear or band‐like patterns over the right half side of her chest, back, and the right upper and lower extremities, following Blaschko's lines. A biopsy specimen demonstrated a dermoepidermal interface inflammation with a lichenoid lymphoid cell infiltrate into the upper and middle dermis. All lesions spontaneously cleared within 2 months. Lichen striatus in an adult should be differentiated from other acquired erythemato‐papular dermatoses which may follow Blaschko's lines. Its histopathological features may mimic those of lichen planus, but it can be distinguished because of its consistent distribution on Blaschko's lines, not only in children but also in adults.
Histamine: The Quintessential Mediator
Authors: Greaves Malcom W. , Sabroe R.A. 
Published: April 2015

AbstractHistamine is unique in being the only substance described to date which fulfils all of the criteria established by Dale for an inflammatory mediator. Thus, histamine is known to cause the “Triple Response” of Lewis and to act via H1 and H2 receptors to produce vasodilation and increased vascular permeability; elevated levels of histamine are found in inflamed tissue; histamine is produced and stored in mast cells and mere are established mechanisms for histamine release via mast cell surface receptors; and antihistamines alleviate the clinical manifestations of histamine release.There have been several recent advances in our understanding of histamine pharmacology and of the pathomechanisms of chronic idiopathic urticaria (CIU), a disease in which histamine plays an important role. Two new histamine receptors have been identified, the inhibitory (H3) receptor and the intracellular (Hic) receptor involved in cell proliferation. There is now evidence that mast cell derived histamine release in patients with CIU is due to an autoimmune disease, mediated by autoantibodies to the α‐subunit of the high affinity IgE receptor on mast cells and basophils. Removal of these autoantibodies by plasmapheresis, or treatment with intravenous immunoglobulins may cause clinical remission. Cyclosporin A has also been found to be of benefit to some patients with CIU probably due to a mast cell “stabilising” effect, leading to reduced release of histamine and other mediators.This article reviews our current knowledge on histamine, its role, receptors and mechanisms for release.
Multiple Basaloid Cell Hamartoma with Alopecia and Autoimmune Disease (Systemic Lupus Erythematosus)
Authors: Akasaka Toshihide , Kon Saiichi , Mihm Martin C. 
Published: April 2015

AbstractWe report a 22‐year‐old Japanese woman with multiple basaloid cell hamartoma with alopecia and autoimmune disease (systemic lupus erythematosus). She presented with infiltrated large annular, brown‐violet, erythematous plaques with atrophic areas in the center on her right cheek, left abdomen and left knee. She also had progressive multiple follicular keratotic papules on her scalp, face, neck, and both axilla and hair loss from her scalp, eyebrow, and axilla. Serologically, reumatoid factor (+++), rheumatoid arthritis hemagglutination test (x1280), and anti‐nuclear antigen (x160) were positive. Histological findings of the annular lesion showed liquefaction degeneration of basal cells, lymphocytic infiltration around hair follicles and capillaries, and panniculitis with lymphoid cell infiltration, which was diagnosed as lupus erythematosus profundus. The histological findings of multiple follicular papular lesions of the scalp and neck showed aggregations of basaloid cells, partially with hair‐bulb‐like structures, which was diagnosed as trichoepithelioma. Taken together, the histogenesis of multiple basaloid cell hamartoma is thought to share the same basis with autoimmune disease.
Squamous Cell Carcinoma Arising from Lupus Vulgaris on an Old Burn Scar: Diagnosis by Polymerase Chain Reaction
Authors: Hagiwara Keisuke , Uezato Hiroshi , Miyazato Hajime , Nonaka Shigeo 
Published: April 2015

AbstractA 66‐year‐old Japanese woman with a squamous cell carcinoma (SCC) arising from lupus vulgaris (LV) on an old burn scar on the left lower extremity is described. Ziel‐Neelsen stain of a direct smear from the surface exudate showed acid‐fast bacilli. Repeated culture for tubercle bacilli was negative, probably due to a technical error. The diagnosis of LV was successfully made by polymerase chain reaction (PCR). LV and burn scar are common preceding diseases for SCC. The former is rare in the U.S., Europe, and Japan. We were unable to determine whether only one of the two conditions or a combination of both was the true predisposing factor responsible for the development of this SCC. However, this case may be the first report of SCC arising from coexistent LV and a burn scar in which the diagnosis was confirmed by PCR.
A Case of Localized Pemphigus Foliaceus
Authors: Yamamoto Shoko , Kanekura Takuro , Gushi Akira , Sekiyama Mitsuhiro , Shimada Tokihiko , Shimada Katsuhiko , Kanzaki Tamotsu 
Published: April 2015

AbstractPemphigus foliaceus (PF) is most commonly observed on the face, scalp, chest and back at the onset of the condition. The case described here is that of an 81‐year‐old female with a single PF lesion localized to the right cheek. A review of the literature published in English and Japanese disclosed only 3 cases of PF in which the patient presented with a single lesion, and 2 of these cases were referred to as “localized pemphigus foliaceus”.
Anti‐Ribosomal P Protein Antibodies in a Japanese Patient with Systemic Sclerosis
Authors: Fujimoto Manabu , Kawakami Tamihiro , Takehara Kazuhiko , Soma Yoshinao 
Published: April 2015

AbstractA 56‐year‐old Japanese woman developed Raynaud's phenomenon and digital ulcerations at the age of 50. She showed rapid and diffuse skin sclerosis; visceral involvement was mild. She showed no symptoms or laboratory findings suggestive of other collagen diseases, including systemic lupus erythematosus and Sjögren's syndrome. Based on the clinical and histological findings, she was diagnosed as having diffuse cutaneous systemic sclerosis (SSc). The patient's serum produced nucleolar and cytoplasmic staining by indirect immunofluorescence analyses on HEp‐2 cell substrate and reacted with P0, P1 and P2 proteins in immunoblotting using purified ribosomal antigens. She was negative for anti‐topoisomerase I, centromere, and U1RNP antibodies. Anti‐ribosomal P protein antibodies are considered highly specific for systemic lupus erythematosus; this is the first case report of an SSc patient with anti‐ribosomal P protein antibodies. The clinical features of SSc patients with these antibodies need to be clarified by an accumulation of cases.
A Low Grade Scirrhous Carcinoma of Eccrine Gland Origin in Adolescence
Authors: Yamamoto Osamu , Yasuda Hiroshi , Asahi Masakazu 
Published: April 2015

AbstractWe report a rare occurrence of adnexal carcinoma in an adolescent A 17‐year‐old Japanese girl had a gradually enlarging tumor on the elbow. Histopathologically, the exophytic tumor showed asymmetrical lobules of tumor embedded in a thickened collagenous stroma. The lobules were composed of various patterns of tumor cell nests ranging from tubular to solid forms. Invasive growth patterns were also observed in the stroma. Two types of the cells, cuboidal and elliptically polygonal, were noted. Immunohistochemistry revealed the presence of S‐100 protein and cytokeratin 8 and the absence of gross cystic disease fluid protein‐15 in the tumor cells. Electron microscopic observation showed a ductal or glandular differentiation and fragmented basal laminae around the nests. Light and electron microscopic findings of this tumor are suggestive of a low‐grade sweat gland carcinoma.
Unusual Cases of Syringoma of the Forehead
Authors: Kim Soo Jung , Ahn Sung Ku , Choi Eung Ho , Lee Seung Hun 
Published: April 2015

AbstractSyringoma involving the forehead is rare and can be confused with other diseases that are common on the forehead. Therefore, we describe here three patients with syringoma who developed numerous skin colored papules on the forehead. To our knowledge, syringoma of the forehead was reported previously only once by Tagami et al.
Disseminated Superficial Porokeratosis with Amyloid Deposition
Authors: Yasuda Kayo , Ikeda Mitsunori , Ikeda Masami , Kodama Hajime 
Published: April 2015

AbstractTwo patients with disseminated superficial porokeratosis (DSP) with amyloid deposition are reported. The skin lesions were distributed over both sun‐exposed areas and sun‐protected areas. No exacerbation by sun exposure was noted. Abundant amyloid substances were deposited at the papillary dermis, not only beneath the cornoid lamellae but also within the annular margin. The skin lesions and amyloid deposition regressed with topical application of dimethyl sulfoxide in one patient, suggesting that DSP is one of the clinical phenotypes of primary localized cutaneous amyloidosis. Another possibility is that amyloid substances are produced by poorly differentiated keratinocytes in DSP.
Rapid Destruction of Murine and Human Melanomas by Local Injection of Absolute Ethanol: Augmentation of the Anti‐proliferative Effects with a Combination of Biological Response Modifiers
Authors: Nakayama Juichiro , Toyofuku Kazutomo , Kokuba Hisashi , Hori Yoshiaki 
Published: April 2015

AbstractPercutaneous injection of absolute ethanol was found to cause rapid destruction of murine and human melanoma nodules. It took only 24–48 hr after the ethanol injection to form ulcers or scars on the lesions. Massive necrosis of murine and human melanoma nests and interstitials and infiltration of mononuclear cells into the demaged tissue were observed histopathologically after ethanol injection. The melanomas recurred approximately 1 week after the destruction of the melanoma nodules by ethanol. Biological response modifiers such as levamisole or interleukin (IL)‐2 were effective in preventing the recurrence of murine melanoma after ethanol injection. IL‐2 injection caused massive infiltration of NK cells, T cells, and macrophages into the damaged melanoma tissue. The therapeutic modality of a combination of ethanol and IL‐2 injections could definitely be useful for the local treatment of human metastatic melanoma, but other modalities such as local hyperthermia or radiation should be considered in combination to attain a permanent cure.
A Case of Acral Melanocytic Hyperplasia: A Unique Pigmented Lesion Mimicking Acral Lentiginous Melanoma In situ
Authors: Cho Kwang Hyun , Kim Byoung Kook , Lee Dong Youn , Minn Kyung Won 
Published: April 2015

AbstractA mottled black pigmented patch on the sole of the foot is reported. Clinically, the lesion closely mimicked acral lentiginous melanoma in situ. However, the histologic findings revealed melanocytic hyperplasia with minimal cytologic atypia confined to the epidermis. Irregular pigmented patches in the acral region comprise a heterogenous group of lesions that range from benign melanocytic hyperplasia to acral lentiginous melanoma.
Urticarial Vasculitis with Papular Lesions in a Patient with Type C Hepatitis and Cryoglobulinemia
Authors: Kuniyuki Shuichi , Katoh Haruhisa 
Published: April 2015

AbstractWe describe a case of urticarial vasculitis accompanied by erythematous wheals, palpable pupura, and subsequent necrotic ulcerated papular lesions in a patient with type C chronic hepatitis and type II cryoglobulinemia (IgM‐kappa and polyclonal IgG). A 56‐year‐old man developed recurrent urticarial lesions on his lower extremities and trunk. The histology revealed leukocytoclastic vasculitis with perivascular immunoglobulin deposits. Subsequently, multiple reddish papular lesions with necrotic ulcerations appeared on the extensor aspect of his extremities and buttocks. Histology of these lesions showed cryoglobulinemic vasculitis with prominent fibrinoid necrosis of the vascular walls and cryoprecipitate within the vasculature as well as increased hyalinized collagen bundles. These papular lesions have not previously been described as cutaneous necrotizing venulitis to the best of our knowledge. It is suggested that the immune response to hepatitis C virus infection and cryoglobulins may be responsible for severe necrotizing venulitis, resulting in unusual cutaneous lesions.
Multiple New‐Onset Subcutaneous Nodules of the Upper Extremity Digits: Giant Cell Tumor of Tendon Sheath and Lipoma
Authors: Cohen Philip R. 
Published: April 2015

AbstractA black woman with the concurrent onset of two subcutaneous nodules located on the digits of her upper extremities is described. Initially, a single systemic disorder was considered; yet, the lesions differed in morphology and consistency. Microscopic examination of the nodules showed a giant cell tumor of tendon sheath and a lipoma. Although Occam's “razor” suggests that multiple lesions in the same person are more likely to represent variable manifestations of a single disorder than several different diseases in that individual, the simultaneously appearing lesions in this patient represented two different conditions.
Systemic Amyloidosis with Initial Polyneuropathy
Authors: Lee Ding‐Dar , Huang Chun‐Yu , Wong Chu‐Kwan , Kao Ko‐Pei 
Published: April 2015

AbstractWe report a case of systemic amyloidosis with the initial sign of polyneuropathy. The patient eventually developed heart failure, macroglossia, and ecchymoses 6 years later. Biopsies from the sural nerve and normal‐looking skin both proved the existence of amyloid.
Thrombospondin Receptor (CD36) Expression of Human Keratinocytes during Wound Healing in a SCID Mouse/Human Skin Repair Model
Authors: Simon Miklós , Juhász István , Herlyn Meenhard , Hunyadi János 
Published: April 2015

AbstractUsing a human skin/severe combined immunodeficient (SCID) chimeric mouse model, we examined the keratinocyte expression of the thrombospondin receptor (CD36) and its ligand thrombospondin‐1 (TSP1) in acute uninflamed wounds. Positive suprabasal keratinocyte expression of CD36 was observed as early as 30 minutes after wounding in the adjacent, intact epidermis; it disappeared 4 days later. Keratinocytes of the freshly re‐epithelised wounds and those of the surrounding epidermis remained TSP1‐negative throughout the whole observation period of 7 days. Our results indicate that CD36‐positive keratinocytes, probably in connection with activated, TSP1‐positive thrombocytes, may play an important role in the early phase of wound healing.
Giant Basal Cell Carcinoma Associated with Systemic Amyloidosis
Authors: Yamamoto Shinji , Johno Masayoshi , Kayashima Ken‐ichi , Matsunaga Wakatoshi , Ono Tomomichi 
Published: April 2015

AbstractA large basal cell carcinoma, 39 times 26 cm in size, is presented as second in size only to the largest basal cell carcinoma documented (40 times 30 cm), reported by Beck and co‐workers (1). A 61‐year‐old Japanese male visited our clinic with a huge ulcerating tumor on the back. He had hidden the tumor for the previous 30 years. The tumor was histologically confirmed as basal cell carcinoma. The condition was associated with anemia, hypoproteinemia, and dyspnea, and with systemic amyloidosis in the skin, in the lymph nodes, and in the intestinal canal. On admission, the tumor had metastasized to the regional lymph nodes, and, about two years after the first operation, there were metastases to bone and lung, leading to death due to respiratory failure.