bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colors and Entrepreneurial Activities: An Exploratory Study
Authors: Hodges Nancy , Kane Michael J. , Link Albert N. 
Published: August 2024

AbstractColors may enhance entrepreneurial behavior. It is well known that creativity can lead to entrepreneurial behavior, and it is argued in the psychology literature that colors can influence an individual’s creativity. In this paper, we explore the empirical relationship between colors and entrepreneurial behavior under the literature-based hypothesis that yellows and oranges enhance an individual’s creative emotions. Our findings open the door for future research on the psychology of colors and entrepreneurship.
Sliding Cycles of Regularized Piecewise Linear Visible–Invisible Twofolds
Authors: Huzak Renato , Kristiansen Kristian Uldall 
Published: August 2024

AbstractThe goal of this paper is to study the number of sliding limit cycles of regularized piecewise linear visible–invisible twofolds using the notion of slow divergence integral. We focus on limit cycles produced by canard cycles located in the half-plane with an invisible fold point. We prove that the integral has at most 1 zero counting multiplicity (when it is not identically zero). This will imply that the canard cycles can produce at most 2 limit cycles. Moreover, we detect regions in the parameter space with 2 limit cycles.
Toxicological and physiological activity of lemongrass and peppermint essential oils as acaricidal agents on life-table parameters of Oligonychus mangiferus (Rahman & Sapra) and its predatory mite, Cydnoseius negevi (Swirskii & Amitai)
Authors: Ahmed Mahmoud Monir , Abdelwines Mohammed Ali 
Published: August 2024

AbstractThe goal of this study is to explore the effects of lemongrass and peppermint essential oils, specifically at their LC50 concentrations, on the demographic parameters of two mite species: Oligonychus mangiferus (Rahman & Sapra) and its predatory mite counterpart, Cydnoseius negevi (Swirskii & Amitai). By evaluating these essential oils, the study aims to contribute to eco-friendly pest management strategies within integrated pest management (IPM) programs. The effects of these oils were assessed in terms of measuring the activity of antioxidant and detoxifying enzymes. GC–MS was used to identify the chemical components of these oils. The main compounds identified by GC–MS in lemongrass and peppermint essential oils were D-Limonene (45.06%), β-Citral (10.30%), α-Citral (9.90%)) and (Menthol (32.03%), Menthone (30.18%), p-Menthan-3-one (11.53%), respectively. The results showed that lemongrass and peppermint were more toxic to O. mangiferus than to C. negevi. Exposure of O. mangiferus to the LC50 of these oils caused a significant increase in peroxidase and catalase enzymes, but it inhibited the detoxifying enzymes, α-esterase, β-esterase, and glutathione s-transferase. Also, these oils had disruptive effects on survival, longevity, and fecundity of O. mangiferus; as they reduced its demographic parameters such as (R0) (GRR) (rm), and (λ). However, they did not show any substantial change in the development time and demographic parameters of C. negevi. On the contrary, they improved its enzymes activity. According to these findings, these essential oils can be used in combination with biological control agents in the integrated pest management strategies against the mango spider mite, O. mangiferus.
Immunotherapy for small cell lung cancer: the current state and future trajectories
Authors: Qiang Min , Liu Hongyang , Yang Lei , Wang Hong , Guo Rui 
Published: August 2024

AbstractSmall cell lung cancer (SCLC) constitutes approximately 10% to 15% of all lung cancer diagnoses and represents a pressing global public health challenge due to its high mortality rates. The efficacy of conventional treatments for SCLC is suboptimal, characterized by limited anti-tumoral effects and frequent relapses. In this context, emerging research has pivoted towards immunotherapy combined with chemotherapy, a rapidly advancing field that has shown promise in ameliorating the clinical outcomes of SCLC patients. Through originally developed for non-small cell lung cancer (NSCLC), these therapies have extended new treatment avenues for SCLC. Currently, a nexus of emerging hot-spot treatments has demonstrated significant therapeutic efficacy. Based on the amalgamation of chemotherapy and immunotherapy, and the development of new immunotherapy agents, the treatment of SCLC has seen the hoping future. Progress has been achieved in enhancing the tumor immune microenvironment through the concomitant use of chemotherapy, immunotherapy, and tyrosine kinase inhibitors (TKI), as evinced by emerging clinical trial data. Moreover, a tripartite approach involving immunotherapy, targeted therapy, and chemotherapy appears auspicious for future clinical applications. Overcoming resistance to post-immunotherapy regimens remains an urgent area of exploration. Finally, bispecific antibodies, adoptive cell transfer (ACT), oncolytic virus, monotherapy, including Delta-like ligand 3 (DLL3) and T cell immunoreceptor with Ig and ITIM domains (TIGIT), as well as precision medicine, may present a prospective route towards achieving curative outcomes in SCLC. This review aims to synthesize extant literature and highlight future directions in SCLC treatment, acknowledging the persistent challenges in the field. Furthermore, the continual development of novel therapeutic agents and technologies renders the future of SCLC treatment increasingly optimistic.
Attenuation of high-fat high-sucrose diet and CCl4-induced non-alcoholic steatohepatitis in rats by activating autophagy and SIGMAR1/GRP78/ITPR1 signaling using berberine-loaded albumin nanoparticles: in vivo prediction and in-silico molecular modeling
Authors: Saleh Samar R. , Younis Fatema A. , Abdelrahman Sahar S. , Attia Azza A. , El‑Demellawy Maha A. , Newairy Al‑Sayeda A. , Ghareeb Doaa A. 
Published: August 2024

Abstract
Purpose
Non-alcoholic fatty liver disease is the most prevalent metabolic disorder that can lead to the development of non-alcoholic steatohepatitis (NASH) and, eventually, result in hepatocellular carcinoma. This study evaluated the therapeutic potential of berberine-loaded bovine serum albumin nanoparticles (BBR-BSA NPs) toward the induced NASH physical, biochemical, and ultrastructural changes.

Methods
NASH was induced in male rats by an high-fat high-sucrose diet (HFHSD) and repeated carbon tetrachloride (CCl4) injections. The treated groups received HFHSD/CCl4 and were then administered BBR, BBR-BSA NPs, BSA NPs, and Atorvastatin for four weeks. Finally, physical, liver function, lipid profile, hepatic oxidative stress, and inflammatory biomarkers were determined. Furthermore, hepatic sigma 1 receptor (SIGMAR1) and autophagy signaling proteins were evaluated. The hepatic transmission electron microscopic and histopathological examinations were also assessed. Finally, the chemical- and protein–protein interaction networks were presented using the visualization tools STITCH 5.0 and STRING databases. In addition, molecular docking analyses were conducted to illustrate the binding of BBR and Atorvastatin toward SREBP-2 and mTOR targets.

Results
The long-term administration of HFHSD/CCl4 had the potential to develop a NASH model. This model is characterized by hepatic steatosis, necro-inflammation, and impaired endoplasmic reticulum-mitochondrial signaling. The results revealed an impaired SIGMAR1 and autophagy flux signaling pathways. In contrast, the administration of BBR-BSA NP improved the therapeutic properties of entrapped BBR on the alterations associated with NASH. The BBR-BSA NPs enhanced the autophagic flux and SIGMAR1 signaling modulators compared to BBR and Atorvastatin. The in-silico bioinformatics analysis demonstrated that BBR exhibited a more robust interaction with SREBP-2 and mTOR compared to Atorvastatin, which supports the in vivo results.

Conclusion
BBR-BSA NPs restored hepatic homeostasis and enhanced the free BBR’s hepatoprotection against the induced NASH via the upregulation of SIGMAR1 and autophagy flux signaling.
Lubrication condition monitoring of journal bearings in diesel engine based on thermoelectricity
Authors: Lv Yuhao , Liu Hao , Chen Zhigang , Chang Weijie , Zhang Hui , Li Hulin 
Published: August 2024

AbstractThere is still a lack of effective lubrication condition monitoring methods in the field of diesel engines. The paper proposes a novel thermoelectric approach to divide the lubrication state of bearings. First, the generation mechanism of thermoelectric potential on bearings is clarified. Then, both experimental and simulation studies are done, and a strong correlation between lubrication and thermoelectric potential is shown. The film thickness and temperature are further confirmed as significant factors influencing thermoelectric potential. Generally, the thermoelectric potential increases with temperature. However, a small film thickness ratio (when the film thickness ratio is less than 4) will suppress the thermoelectric potential. Three typical lubrication states of bearings are distinguished through thermoelectric potential and supported by the Stribeck curve results. Moreover, the significant influence of lubrication on the bearing is confirmed through the analysis of surface morphology and composition.
Enhancing Defect-Induced Dipole Polarization Strategy of SiC@MoO3 Nanocomposite Towards Electromagnetic Wave Absorption
Authors: Wang Ting , Zhao Wenxin , Miao Yukun , Cui Anguo , Gao Chuanhui , Wang Chang , Yuan Liying , Tian Zhongning , Meng Alan , Li Zhenjiang , Zhang Meng 
Published: August 2024

AbstractDefect engineering in transition metal oxides semiconductors (TMOs) is attracting considerable interest due to its potential to enhance conductivity by intentionally introducing defects that modulate the electronic structures of the materials. However, achieving a comprehensive understanding of the relationship between micro-structures and electromagnetic wave absorption capabilities remains elusive, posing a substantial challenge to the advancement of TMOs absorbers. The current research describes a process for the deposition of a MoO3 layer onto SiC nanowires, achieved via electro-deposition followed by high-temperature calcination. Subsequently, intentional creation of oxygen vacancies within the MoO3 layer was carried out, facilitating the precise adjustment of electromagnetic properties to enhance the microwave absorption performance of the material. Remarkably, the SiC@MO-t4 sample exhibited an excellent minimum reflection loss of − 50.49 dB at a matching thickness of 1.27 mm. Furthermore, the SiC@MO-t6 sample exhibited an effective absorption bandwidth of 8.72 GHz with a thickness of 2.81 mm, comprehensively covering the entire Ku band. These results not only highlight the pivotal role of defect engineering in the nuanced adjustment of electromagnetic properties but also provide valuable insight for the application of defect engineering methods in broadening the spectrum of electromagnetic wave absor ption effectiveness. SiC@MO-t samples with varying concentrations of oxygen vacancies were prepared through in-situ etching of the SiC@MoO3 nanocomposite. The presence of oxygen vacancies plays a crucial role in adjusting the band gap and local electron distribution, which in turn enhances conductivity loss and induced polarization loss capacity. This finding reveals a novel strategy for improving the absorption properties of electromagnetic waves through defect engineering.
Turbulence and transport by electron temperature gradient driven instability in large volume plasma device
Authors: Awasthi L. M. , Srivastav Prabhakar , Singh S. K. , Sanyasi A. K. , Srivastava P. K. , Singh Rameswar , Sugandhi R. , Singh R. , Mattoo S. K. 
Published: August 2024

AbstractWe present a topical review of the detailed experimental investigations of the Electron Temperature Gradient (ETG) instability-induced turbulence and associated transport that have been carried out in the Large Volume Plasma Device (LVPD) at the Institute for Plasma Research. These results pertaining to a high beta plasma are supported by theoretical modeling and their significance with relation to earlier ETG investigations are discussed. The removal of non-thermal electrons and control of electron temperature gradient, $$\nabla {T}_{e}$$

∇

T
e

are achieved in a finite beta plasma (β ∼ 0.6) by making use of an Electron Energy Filter (EEF). It divides the plasma into source, EEF and target regions. In the core region ($$x\le 50$$

x
≤
50

cm) of target plasma, the observed electromagnetic instability exhibits fluctuations in the lower hybrid range of frequencies ($$f=1-80 kHz$$

f
=
1
-
80
k
H
z

), with a broad band spectra having its peak power at wave number, $${k}_{\perp }=\left(0.1-0.2\right)$$

k
⊥

=

0.1
-
0.2

cm−1 and frequency, f ~ 10 kHz satisfying condition $${k}_{\perp }{\rho }_{e}\le 1$$

k
⊥

ρ
e

≤
1

and $${k}_{\parallel }/{k}_{\perp }<$$

k
‖

/

k
⊥

<

1, where $${\rho }_{e}$$

ρ
e

is the electron Larmor radius and $${k}_{\perp }$$

k
⊥

and $${k}_{\parallel }$$

k
‖

are the perpendicular and parallel wave numbers, respectively. It was demonstrated successfully that when $$\nabla {T}_{e}$$

∇

T
e

is made significant such that$${\eta }_{e}\approx {L}_{n}/{L}_{Te}>2/3$$

η
e

≈

L
n

/

L

Te

>
2
/
3

, where $${L}_{n}$$

L
n

is density scale length and $${L}_{Te}$$

L

Te

is electron temperature scale length, the ETG scale turbulence gets excited in the presence of pre-excited Whistler mode. A linear theory of coupled Whistler-Electron Temperature Gradient (W-ETG) mode is developed using a two-fluid model applicable for the LVPD plasma. A comparison of the experimental and numerical results is found to be in good agreement. Upon identification of the ETG turbulence, the electrostatic and electromagnetic particle fluxes and energy flux induced by it in the target region of LVPD were investigated. We observed an inward directed radial particle flux, but total heat flux remained radially outward. The particle and thermal fluxes are compared with the numerically obtained values and are found to be in good agreement in the core plasma of LVPD.
Process Modeling of Mineral Dissolution From Nano‐Scale Surface Topography Observations
Authors: Starnoni M. , Sanchez‐Vila X. , Recalcati C. , Riva M. , Guadagnini A. 
Published: August 2024

AbstractWe present an innovative approach that combines a unique real‐time data set documenting absolute dissolution rates of a calcite crystal with an original reactive transport model tailored to the analysis of the dynamics of nano‐scale mineral dissolution processes. Providing robust and physically based fundamental understanding on the kinetics of mineral dissolution is at the core of various geo‐engineered strategies to quantify chemical weathering patterns across diverse spatial and temporal scales. Here, we rely on data obtained through Atomic Force Microscopy. We provide a mathematical framework to describe three‐dimensional dynamics of the mineral surface topography, and show convergence of the numerical approach for vertical grid spacing down to sub‐nm resolution.
Consumptive Water Use and Efficiency of Irrigated U.S. Corn: Learning From Hundreds of Site‐Management‐Year Observations
Authors: Kukal Meetpal S. 
Published: August 2024

AbstractGrain yield response to consumptive water use a.k.a. evapotranspiration (ETc) is a critical dimension of food‐water nexus in irrigated agroecosystems. With the largest water footprint, irrigated corn production in the U.S. must be assessed for its ETc and water use efficiency (WUE) at a scale meaningful for producers and water managers. Field experiments significantly inform our understanding of how corn yield responds to ETc at the field/plot‐level, but their collective synergism remains untapped. This analysis uses a literature synthesis of existing measured data from nationwide experiments that measured corn ETc, to build models that elucidate and predict corn ETc and WUE under diverse environment and on‐farm management. The resulting synthesis (n = 1,362) captured wide ranging conditions of mean aridity, environmental variability, management, and crop outcomes, providing an unprecedented opportunity to train data‐driven models. Random forest models effectively predicted seasonal total ETc and seasonal mean WUE using a handful of environmental and management‐based predictors, demonstrating RMSEs of 33 mm (5.1%) and 0.28 kg m−3 (10.4%), respectively. Irrigation depth was the most important followed by total precipitation received during the growing season in determining ETc and WUE. Trained on the largest compilation of experimental data sets of corn ETc, these data‐driven models represent nuanced corn water production functions that also account for weather and agronomy besides describing economic yield‐ETc response.
A retrospective analysis of NHS patient dental charges in England, Scotland and Wales
Authors: Chestnutt Ivor G. , Cope Anwen L. 
Published: August 2024

AbstractObjectives This analysis aimed to: i) review how patient dental charges (PDCs) changed over time in England, Scotland and Wales; ii) determine how these changes relate to a) inflation and b) minimum wages; and iii) how the charges have varied in the devolved administrations.Methods Data were obtained from NHS and Office for National Statistics (ONS) records and historical valuations of the national living wage (NLW). General inflation was calculated using the ONS Consumer Price Index.Results PDCs differed significantly between countries in relation to cost; which aspects of dental care require a charge; and value of payments (p <0.001). PDCs in England for simple, intermediate and more complex care rose from £15.90, £43.60 and £194.00 in 2007, to £25.80, £70.70 and £306.80 in 2023. Adjusted for inflation, the 2007 prices equate to £25.53, £70.02 and £311.55, demonstrating that the relative costs have remained constant in England. In Wales, 2007 prices (inflation-adjusted):2023 prices for the three complexities of treatment were £19.27:£14.80, £62.23:£47.33 and £284.25:£204.43. In Scotland, PDCs for the four treatment items fell marginally when adjusted for inflation. The ratio of PDC:NLW fell by an average of 13.8% in England and 30.7% in Wales.Conclusions There has been significant variation in the approach to PDCs across Great Britain both in terms of nominal costs and the degree to which these have kept pace with inflation.
Experimentally altering microRNA levels in embryos alters adult phenotypes
Authors: Yilmaz Sukranli Zeynep , Korkmaz Bayram Keziban , Taheri Serpil , Cuzin Francois , Ozkul Yusuf , Rassoulzadegan Minoo 
Published: August 2024

AbstractWe previously identified a unique genetic feature of Autism Spectrum Disorder (ASD) in human patients and established mouse models, a low to very low level of six microRNAs, miR-19a-3p, miR-361-5p, miR-3613-3p, miR-150-5p, miR-126-3p and miR-499a-5p. We attempted to interfere experimentally in mice with two of them, miR19a-3p and miR499a-5p by microinjecting into zygote pronuclei either the complementary sequence or an excess of the microRNA. Both resulted in low levels in the tissues and sperm of the targeted microRNAs and their pri and pre precursors. This method stably modify predetermined levels of miRNAs and identify miRNA alterations that cause changes in autistic behavior and predispose the individual to an inherited disease. Excess miRNA results in single-stranded miRNA variations in both free and DNA-bound RNA (R-loop) fractions in mouse models thus appearing to affect their own transcription. Analysis of miRNAs fractions in human patients blood samples confirm low level of six microRNAs also in R-loop fractions.
Alpine viper in changing climate: thermal ecology and prospects of a cold-adapted reptile in the warming Mediterranean
Authors: Mizsei Edvárd , Radovics Dávid , Rák Gergő , Budai Mátyás , Bancsik Barnabás , Szabolcs Márton , Sos Tibor , Lengyel Szabolcs 
Published: August 2024

AbstractIn a rapidly changing thermal environment, reptiles are primarily dependent on in situ adaptation because of their limited ability to disperse and the restricted opportunity to shift their ranges. However, the rapid pace of climate change may surpass these adaptation capabilities or elevate energy expenditures. Therefore, understanding the variability in thermal traits at both individual and population scales is crucial, offering insights into reptiles' vulnerability to climate change. We studied the thermal ecology of the endangered Greek meadow viper (Viperagraeca), an endemic venomous snake of fragmented alpine-subalpine meadows above 1600 m of the Pindos mountain range in Greece and Albania, to assess its susceptibility to anticipated changes in the alpine thermal environment. We measured preferred body temperature in artificial thermal gradient, field body temperatures of 74 individuals in five populations encompassing the entire geographic range of the species, and collected data on the available of temperatures for thermoregulation. We found that the preferred body temperature (Tp) differed only between the northernmost and the southernmost populations and increased with female body size but did not depend on sex or the gravidity status of females. Tp increased with latitude but was unaffected by the phylogenetic position of the populations. We also found high accuracy of thermoregulation in V.graeca populations and variation in the thermal quality of habitats throughout the range. The overall effectiveness of thermoregulation was high, indicating that V.graeca successfully achieves its target temperatures and exploits the thermal landscape. Current climatic conditions limit the activity period by an estimated 1278 h per year, which is expected to increase considerably under future climate scenarios. Restricted time available for thermoregulation, foraging and reproduction will represent a serious threat to the fitness of individuals and the persistence of populations in addition to habitat loss due to mining, tourism or skiing and habitat degradation due to overgrazing in the shrinking mountaintop habitats of V.graeca.
Graphene-based nanocomposites as gamma- and X-ray radiation shield
Authors: Filak-Mędoń Karolina , Fornalski Krzysztof W. , Bonczyk Michał , Jakubowska Alicja , Kempny Kamila , Wołoszczuk Katarzyna , Filipczak Krzysztof , Żerańska Klaudia , Zdrojek Mariusz 
Published: August 2024

AbstractCommonly used materials for protection against ionizing radiation (gamma and X-ray energy range) primarily rely on high-density materials, like lead, steel, or tungsten. However, these materials are heavy and often impractical for various applications, especially where weight is a key parameter, like in avionics or space technology. Here, we study the shielding properties of an alternative light material—a graphene-based composite with a relatively low density ~ 1 g/cm3. We demonstrate that the linear attenuation coefficient is energy of radiation dependent, and it is validated by the XCOM model, showing relatively good agreement. We also show that the mass attenuation coefficient for selected radiation energies is at least comparable with other known materials, exceeding the value of 0.2 cm2/g for higher energies. This study proves the usefulness of a commonly used model for predicting the attenuation of gamma and X-ray radiation for new materials. It shows a new potential candidate for shielding application.