bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential causes of subfertility in patients with intramural fibroids
Authors: Pier Bruce D. , Bates G. Wright 
Published: August 2015

Abstract
Background
Intramural leiomyomas have been long debated as a potential cause of infertility and pregnancy loss.

Findings
Previous research has linked intramural fibroids to defective implantation, as well as to abnormal peristaltic events of the uterine smooth muscle. Previous reports describe the effects of intramural fibroids on normal human fertility and early pregnancy loss, specifically in regards to implantation failure.

Conclusion
A thorough understanding of prior research may direct new research focus, leading to better understanding of leiomyoma-associated infertility.
Draft genome sequence of marine-derived Streptomyces sp. TP-A0598, a producer of anti-MRSA antibiotic lydicamycins
Authors: Komaki Hisayuki , Ichikawa Natsuko , Hosoyama Akira , Fujita Nobuyuki , Igarashi Yasuhiro 
Published: August 2015

AbstractStreptomyces sp. TP-A0598, isolated from seawater, produces lydicamycin, structurally unique type I polyketide bearing two nitrogen-containing five-membered rings, and four congeners TPU-0037-A, −B, −C, and –D. We herein report the 8 Mb draft genome sequence of this strain, together with classification and features of the organism and generation, annotation and analysis of the genome sequence. The genome encodes 7,240 putative ORFs, of which 4,450 ORFs were assigned with COG categories. Also, 66 tRNA genes and one rRNA operon were identified. The genome contains eight gene clusters involved in the production of polyketides and nonribosomal peptides. Among them, a PKS/NRPS gene cluster was assigned to be responsible for lydicamycin biosynthesis and a plausible biosynthetic pathway was proposed on the basis of gene function prediction. This genome sequence data will facilitate to probe the potential of secondary metabolism in marine-derived Streptomyces.
Dual role of ERK5 in the regulation of T cell receptor expression at the T cell surface
Authors: Rovira-Clavé Xavier , Angulo-Ibáñez Maria , Tournier Cathy , Reina Manuel , Espel Enric 
Published: August 2015

Abstract
Regulation of the levels of the TCR/CD3 complex at the cell surface is critical to proper T cell development and mature T cell activation. We provide evidence that the MAPK ERK5 regulates the surface expression of the TCR/CD3 complex by controlling the degradation of the CD3ζ chain and the recovery of the complex after anti-CD3ɛ stimulation. ERK5 knockdown led to TCR/CD3 up-regulation at the cell surface and increased amounts of the CD3ζ chain. Inhibition of the MEK5-dependent phosphorylation status of the kinase domain of ERK5 in human T CD4+ cells reduced CD3ζ ubiquitination and degradation, limiting TCR/CD3 down-regulation in anti-CD3-stimulated cells. Moreover, TCR/CD3 recovery at the cell surface, after anti-CD3ɛ treatment, is impaired by ERK5 knockdown or pharmacological inhibition of autophosphorylation in the ERK5 C-terminal region. ERK5 loss in thymocytes augmented cellular CD3ζ and increased cell surface levels of TCR/CD3 on CD4+CD8+ thymocytes. This correlated with enhanced generation of CD4+CD8−CD25+ thymocytes. Our findings define ERK5 as a novel kinase that modulates the levels of TCR/CD3 at the cell surface by promoting CD3ζ degradation and TCR/CD3 recovery after TCR stimulation.
Methamphetamine induces trace amine-associated receptor 1 (TAAR1) expression in human T lymphocytes: role in immunomodulation
Authors: Sriram Uma , Cenna Jonathan M , Haldar Bijayesh , Fernandes Nicole C , Razmpour Roshanak , Fan Shongshan , Ramirez Servio H , Potula Raghava 
Published: August 2015

Abstract
The novel transmembrane G protein-coupled receptor, trace amine-associated receptor 1 (TAAR1), represents a potential, direct target for drugs of abuse and monoaminergic compounds, including amphetamines. For the first time, our studies have illustrated that there is an induction of TAAR1 mRNA expression in resting T lymphocytes in response to methamphetamine. Methamphetamine treatment for 6 h significantly increased TAAR1 mRNA expression (P &lt; 0.001) and protein expression (P &lt; 0.01) at 24 h. With the use of TAAR1 gene silencing, we demonstrate that methamphetamine-induced cAMP, a classic response to methamphetamine stimulation, is regulated via TAAR1. We also show by TAAR1 knockdown that the down-regulation of IL-2 in T cells by methamphetamine, which we reported earlier, is indeed regulated by TAAR1. Our results also show the presence of TAAR1 in human lymph nodes from HIV-1-infected patients, with or without a history of methamphetamine abuse. TAAR1 expression on lymphocytes was largely in the paracortical lymphoid area of the lymph nodes with enhanced expression in lymph nodes of HIV-1-infected methamphetamine abusers rather than infected-only subjects. In vitro analysis of HIV-1 infection of human PBMCs revealed increased TAAR1 expression in the presence of methamphetamine. In summary, the ability of methamphetamine to activate trace TAAR1 in vitro and to regulate important T cell functions, such as cAMP activation and IL-2 production; the expression of TAAR1 in T lymphocytes in peripheral lymphoid organs, such as lymph nodes; and our in vitro HIV-1 infection model in PBMCs suggests that TAAR1 may play an important role in methamphetamine -mediated immune-modulatory responses.
Association Between Geographic Access to Cancer Care, Insurance, and Receipt of Chemotherapy: Geographic Distribution of Oncologists and Travel Distance
Authors: Lin Chun Chieh , Bruinooge Suanna S. , Kirkwood M. Kelsey , Olsen Christine , Jemal Ahmedin , Bajorin Dean , Giordano Sharon H. , Goldstein Michael , Guadagnolo B. Ashleigh , Kosty Michael , Hopkins Shane , Yu James B. , Arnone Anna , Hanley Amy , Stevens Stephanie , Hershman Dawn L. 
Published: August 2015

Purpose Geographic access to care may be associated with receipt of chemotherapy but has not been fully examined. This study sought to evaluate the association between density of oncologists and travel distance and receipt of adjuvant chemotherapy for colon cancer within 90 days of colectomy. Patients and Methods Patients in the National Cancer Data Base with stage III colon cancer, diagnosed between 2007 and 2010, and age 18 to 80 years were selected. Generalized estimating equation clustering by hospital service area was conducted to examine the association between geographic access and receipt of oncology services, controlling for patient sociodemographic and clinical characteristics. Results Of 34,694 patients in the study cohort, 75.7% received adjuvant chemotherapy within 90 days of colectomy. Compared with travel distance less than 12.5 miles, patients who traveled 50 to 249 miles (odds ratio [OR], 0.87; P = .009) or ≥ 250 miles (OR, 0.36; P < .001) had decreased likelihood of receiving adjuvant chemotherapy. Density level of oncologists was not statistically associated with receipt of adjuvant chemotherapy (low v high density: OR, 0.98; P = .77). When stratifying analyses by insurance status, non–privately insured patients who resided in areas with low density of oncologists were less likely to receive adjuvant chemotherapy (OR, 0.85; P = .03). Conclusion Increased travel burden was associated with a decreased likelihood of receiving adjuvant chemotherapy, regardless of insurance status. Patients with nonprivate insurance who resided in low-density oncologist areas were less likely to receive adjuvant chemotherapy. If these findings are validated prospectively, interventions to decrease geographic barriers may improve the timeliness and quality of colon cancer treatment.
Impact of Precision Medicine in Diverse Cancers: A Meta-Analysis of Phase II Clinical Trials
Authors: Schwaederle Maria , Zhao Melissa , Lee J. Jack , Eggermont Alexander M. , Schilsky Richard L. , Mendelsohn John , Lazar Vladimir , Kurzrock Razelle 
Published: August 2015

Purpose The impact of a personalized cancer treatment strategy (ie, matching patients with drugs based on specific biomarkers) is still a matter of debate. Methods We reviewed phase II single-agent studies (570 studies; 32,149 patients) published between January 1, 2010, and December 31, 2012 (PubMed search). Response rate (RR), progression-free survival (PFS), and overall survival (OS) were compared for arms that used a personalized strategy versus those that did not. Results Multivariable analysis (both weighted multiple linear regression and random effects meta-regression) demonstrated that the personalized approach, compared with a nonpersonalized approach, consistently and independently correlated with higher median RR (31% v 10.5%, respectively; P < .001) and prolonged median PFS (5.9 v 2.7 months, respectively; P < .001) and OS (13.7 v 8.9 months, respectively; P < .001). Nonpersonalized targeted arms had poorer outcomes compared with either personalized targeted therapy or cytotoxics, with median RR of 4%, 30%, and 11.9%, respectively; median PFS of 2.6, 6.9, and 3.3 months, respectively (all P < .001); and median OS of 8.7, 15.9, and 9.4 months, respectively (all P < .05). Personalized arms using a genomic biomarker had higher median RR and prolonged median PFS and OS (all P ≤ .05) compared with personalized arms using a protein biomarker. A personalized strategy was associated with a lower treatment-related death rate than a nonpersonalized strategy (median, 1.5% v 2.3%, respectively; P < .001). Conclusion Comprehensive analysis of phase II, single-agent arms revealed that, across malignancies, a personalized strategy was an independent predictor of better outcomes and fewer toxic deaths. In addition, nonpersonalized targeted therapies were associated with significantly poorer outcomes than cytotoxic agents, which in turn were worse than personalized targeted therapy.
Samantha doesn't say no - She’s leaving the company, isn’t she?
Authors: Menegon Leticia Fantinato , Zaccarelli Laura Menegon , Casado Tania 
Published: August 2015

A Human Resources professional faces a series of dilemmas, all related to the delicate balance between career and personal life. What priorities should she attend? Uma profissional de Recursos Humanos enfrenta uma série de dilemas relacionados ao delicado equilíbrio entre carreira e vida pessoal. Quais devem ser as prioridades? [Caso submetido originalmente em inglês. A GVcasos o publica acompanhado de uma versão ao português]
Pandemic 2009 Influenza A (H1N1) virus infection in cancer and hematopoietic stem cell transplant recipients; a multicenter observational study.
Authors: Dignani Maria Cecilia , Costantini Patricia , Salgueira Claudia , Jordán Rosana , Guerrini Graciela , Valledor Alejandra , Herrera Fabián , Nenna Andrea , Mora Claudia , Roccia-Rossi Inés , Stecher Daniel , Carbone Edith , Laborde Ana , Efron Ernesto , Altclas Javier , Calmaggi Aníbal , Cozzi José 
Published: August 2015

Background: During March 2009 a novel Influenza A virus emerged in Mexico. We describe the clinical picture of the pandemic Influenza A (H1N1) Influenza in cancer patients during the 2009 influenza season.Methods: Twelve centers participated in a multicenter retrospective observational study of cancer patients with confirmed infection with the 2009 H1N1 Influenza A virus (influenza-like illness or pneumonia plus positive PCR for the 2009 H1N1 Influenza A virus in respiratory secretions). Clinical data were obtained by retrospective chart review and analyzed. Results: From May to August 2009, data of 65 patients were collected. Median age was 51 years, 57 % of the patients were female. Most patients (47) had onco-hematological cancers and 18 had solid tumors. Cancer treatment mainly consisted of chemotherapy (46), or stem cell transplantation (SCT) (16). Only 19 of 64 patients had received the 2009 seasonal Influenza vaccine. Clinical presentation included pneumonia (43) and upper respiratory tract infection (22). Forty five of 58 ambulatory patients were admitted. Mechanical ventilation was required in 12 patients (18%). Treatment included oseltamivir monotherapy or in combination with amantadine for a median of 7 days. The global 30-day mortality rate was 18%. All 12 deaths were among the non-vaccinated patients. No deaths were observed among the 19 vaccinated patients. Oxygen saturation <96% at presentation was a predictor of mortality (OR 19.5; 95%CI: 2.28 to 165.9).Conclusions: In our cancer patient population, the pandemic 2009 Influenza A (H1N1) virus was associated with high incidence of pneumonia (66%), and 30-day mortality (18.5%). Saturation <96% was significantly associated with death. No deaths were observed among vaccinated patients.
Hippocampal development and the dissociation of cognitive-spatial mapping from motor performance
Authors: Devan Bryan D. , Magalis Christopher , McDonald Robert J. 
Published: August 2015

The publication of a recent article inF1000Researchhas led to discussion of, and correspondence on a broader issue that has a long history in the fields of neuroscience and psychology. Namely, is it possible to separate the cognitive components of performance, in this case spatial behavior, from the motoric demands of a task? Early psychological experiments attempted such a dissociation by studying a form of spatial maze learning where initially rats were allowed to explore a complex maze, termed “latent learning,” before reinforcement was introduced. Those rats afforded the latent learning experience solved the task faster than those that were not, implying that cognitive map learning during exploration aided in the performance of the task once a motivational component was introduced. This form of latent learning was interpreted as successfully demonstrating that an exploratory cognitive map component was acquired irrespective of performing a learned spatial response under deprivation/motivational conditions. The neural substrate for cognitive learning was hypothesized to depend on place cells within the hippocampus. Subsequent behavioral studies attempted to directly eliminate the motor component of spatial learning by allowing rats to passively view the distal environment before performing any motor response using a task that is widely considered to be hippocampal-dependent. Latent learning in the water maze, using a passive placement procedure has met with mixed results. One constraint on viewing cues before performing a learned swimming response to a hidden goal has been the act of dynamically viewing distal cues while moving through a part of the environment where an optimal learned spatial escape response would be observed. We briefly review these past findings obtained with adult animals to the recent efforts of establishing a “behavioral topology” separating cognitive-spatial learning from tasks differing in motoric demands in an attempt to define when cognitive-spatial behavior emerges during development.
Scheduling Multiple Yard Cranes with Crane Interference and Safety Distance Requirement
Authors: Wu Yong , Li Wenkai , Petering Matthew E. H. , Goh Mark , Souza Robert de 
Published: August 2015

Container terminals require robust scheduling algorithms for yard cranes to optimally determine the sequence of storage and retrieval operations in yard blocks for higher container terminal performance. This paper investigates the multiple yard crane scheduling problem within a generic yard block and considers the operational restrictions such as the crane noncrossing constraint and models the crane travel time realistically. Further, the fact that any two adjacent cranes must keep an operational safety distance is also taken into consideration. These physical constraints limit the mobility of yard cranes and greatly render the scheduling difficulty for such pieces of equipment. This paper proposes a clustering-reassigning approach, which fully considers all of the operational constraints in practice. The complexity of the approach is o(n3), where n is the number of container moves to be scheduled, making it suitable for real-time scheduling. Numerical experiments and benchmark with a continuous time-based mixed-integer linear programming model indicate that the clustering-reassigning approach can provide satisfactory near optimal solutions for different sets of test cases in a real-time scheduling context.
Taking initiative in educational organizations: A scale development study<p>Eğitim örgütlerinde inisiyatif alma: Bir ölçek geliştirme çalışması
Authors: Gündüz Hasan Basri , Çakmak Esra , Korumaz Mithat 
Published: August 2015

The purpose of the study is to develop a reliable and valid scale for individual initiative in educational organizations. The draft form to get experts’ opinion was presented. After getting feedback of experts, unsuitable items were removed from the scale. Pilot implementation showed that the language of the scale is suitable for the basic implementation. 39-item form was administrated to 370 volunteer inspectors, principals and teachers in different educational units. Confirmatory factor analysis, difference tests between %27, construct validity, reliability, item total, item removed and other tests were applied for developing the scale. All those statistical analysis showed that initiative of individuals can be assess into four dimensions. These dimensions are “self-starting”, ”overcoming the barriers”, “proactive action” and “self-investment”. The scale with 35-item that is shaped through experts’ opinion after statistical tests are developed as a valid and reliable scale for educational organizations.<br /> <br /><strong>Özet</strong><br /><br />Bu çalışmanın amacı eğitim örgütlerinde kullanılabilecek bir inisiyatif alma ölçeğinin geliştirilmesidir. Bu amaçla taslak form oluşturulmuştur. Oluşturulan taslak form görüşlerinin alınması için uzmanlara sunulmuştur. Uzmanlardan alınan geri bildirimler ile ölçeğin yapısına uygun olmayan maddeler ölçekten çıkarılmıştır. Oluşan 39 maddelik nihai form kasıtlı örnekleme yöntemi ile seçilen 370 müfettiş, müdür, müdür yardımcısı ve öğretmene uygulanmış elde edilen veriler ölçek geliştirme sürecine uygun olarak analiz edilmiştir. Araştırma kapsamında inisiyatif alma ölçeğinin geliştirilmesi sürecinde madde toplam, madde kalan, alt ve üst %27’lik gruplar arasında fark testleri, doğrulayıcı faktör analizi, yapı geçerliliği ve güvenirlik analizleri yapılmıştır. Yapılan tüm bu istatistiki sınamalar, alan yazın ve uzman görüşleri doğrultusunda son şekli verilen, “başlatıcılık”, “engelleri aşma”, “basiret gösterme” ve “öz-yatırım” boyutlarından oluşan, eğitim örgütlerinde kullanılabilecek 35 maddelik geçerli ve güvenilir bir inisiyatif alma ölçeği geliştirilmiştir.
Infertility as the onset of Cushing’s disease: is pasireotide a treatment option?
Authors: Valea Ana , Morar Andra , Dumitru D.P. , Carsote Mara , Ghemigian Adina , Dumitrache C. 
Published: August 2015

ABSTRACT
Introduction Cushing’s disease is a complex endocrine disorder characterized by excessive glucocorticoid secretion caused by an ACTH-secreting pituitary adenoma. Hyperandrogenism and menstrual disorders such as amenorrhea and oligomenorrhea complete the clinical picture of Cushing’s syndrome. Infertility is relatively common, involving complex pathogenetic mechanisms, which differ depending on the cause of hypercortisolism.
Case presentation We present the case of a female patient diagnosed with Cushing’s disease during the investigations carried out to assess infertility. After transsphenoidal adenomectomy, the patient underwent treatment with pasireotide and dopamine agonists, achieving normalization of gonadotropin and estradiol levels.
Conclusion Current guidelines recommended transsphenoidal adenomectomy as first-line therapy in an attempt to correct hypercortisolism and restore fertility in patients with Cushing’s disease. In case of relapse pasireotide and dopamine agonists can be effective in normalizing the hormonal profile
Menopause and prolactin secreting tumours
Authors: Carsote Mara , Valea Ana , Dumitrascu Anda , Capatina Cristina , Paun Diana , Poiana Catalina , Ghemigian Adina 
Published: August 2015

ABSTRACT
Introduction Prolactinomas without galactorhhea may be considered menopause or not diagnosed. This is a cases series.
Case1. 76-year female with menopause at age of 52 was discovered at 66 yrs with high prolactin and a pituitary micro-nodule. Bromocriptin was continued for 6 years then switched to cabergoline with constant imagery. The patient did not display at all galactorrhea. Osteoporosis was diagnosed at age of 66 with previous 2 fragility fractures.
Case2. 45-year female is known with secondary amenorrhea (without galactorrhea) for the last 7 years being considered menopause. She experienced headaches thus a MRI was performed and found a pituitary tumour of 1.5cm. Low FSH with increased prolactin was revealed. Cabergoline was started. Within 2 months the menses resumed and headache mildly improved. After 3 months prolactin normalised under weekly 2 mg of cabergoline. Periodical prolactin control is necessary as well as a pituitary scan at 6 months.
Case3. 39-year female had a 3 yrs history of secondary amenorrhea. A prolactin of 117ng/mL and a microprolactinoma of 0.77cm were found. Cabergoline was started and progressively increased up to 1.5mg per week. The prolactin quickly normalised up to 8ng/mL within 4 months. She was followed for 2 years and the imagery found a tumour reduction to 0.44cm.
Conclusion Prolactinomas associate a great variety of clinical presentations. They interfere with menopause by mimicking it in cases without galactorrhea. Also a newly diagnosed prolactinoma during menopause needs long term therapy and followed-up for especially for bone safety.
Am I an Active Citizen? Women’s Narratives of Citizenship Practices in Albania
Authors: Çela Eriada 
Published: August 2015

Abstract
This study explores the topic of citizenship as related to the practices of twelve Albanian women. This research utilizes literature on gender and citizenship as a framework for comparing and analysing the narratives of women who exert their political citizenship through civil society and governmental political bodies. First, this study explores the ways the interviewees perceive citizenship while analysing women’s narratives to get at their spoken and unspoken specificities. Secondly, it discusses their conceptualisations of themselves as active citizens and analyses how their expressed perceptions relate to their identification as political actors with regards to their identities as women. Thirdly, it analyses issues of relevance to women’s engagement as active citizens as they appear from women’s individual experiences of citizenship in the narratives. This research focuses on the way interviewed Albanian women perceive themselves in relation to their citizenship and what their experiences as citizens say about their self-identification as agents with a say in the issues that affect their lives.
Free Algebras Over a Poset in Varieties of Łukasiewicz–Moisil Algebras
Authors: Orellano A. Figallo , Gallardo C. 
Published: August 2015

AbstractA general construction of the free algebra over a poset in varieties finitely generated is given in [8]. In this paper, we apply this to the varieties of Łukasiewicz-Moisil algebras, giving a detailed description of the free algebra over a finite poset (X, ≤) , Free
Fractional Representation Formulae Under Initial Conditions and Fractional Ostrowski Type Inequalities
Authors: Anastassiou George A. 
Published: August 2015

AbstractHere we present very general fractional representation formulae for a function in terms of the fractional Riemann-Liouville integrals of different orders of the function and its ordinary derivatives under initial conditions. Based on these, we derive general fractional Ostrowski type inequalities with respect to all basic norms.