bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diabetes mellitus, hearing loss, and therapeutic interventions: A systematic review of insights from preclinical animal models
Authors: Mittal Rahul , Keith Grant , Lacey Mitchel , Lemos Joana R. N. , Mittal Jeenu , Assayed Amro , Hirani Khemraj 
Published: July 2024

Objectives
The aim of this systematic review article is to evaluate the relationship between diabetes mellitus (DM) and sensorineural hearing loss (SNHL) utilizing preclinical animal models. The review focused on studies assessing SNHL in diabetic animal models, elucidating the mechanisms of DM-associated SNHL, and exploring the response of diabetic animal models to noise overexposure. We also discussed studies investigating the efficacy of potential therapeutic strategies for amelioration of DM-associated SNHL in the animal models.

Methods
A protocol of this systematic review was designed a priori and was registered in the PROSPERO database (registration number: CRD42023439961). We conducted a comprehensive search on PubMed, Science Direct, Web of Science, Scopus, and EMBASE databases. A minimum of three reviewers independently screened, selected, and extracted data. The risk of bias assessment of eligible studies was conducted using the Systematic Review Center for Laboratory Animal Experimentation (SYRCLE) tool.

Results
Following the screening of 238 studies, twelve original articles were included in this systematic review. The studies revealed that hyperglycemia significantly affects auditory function, with various pathological mechanisms contributing to DM-induced hearing impairment, including cochlear synaptopathy, microangiopathy, neuropathy, oxidative stress, mitochondrial abnormalities, and apoptosis-mediated cell death. Emerging interventions, such as Asiaticoside, Trigonelline, Chlorogenic acid, and Huotanquyu granules, demonstrated efficacy in providing otoprotection for preserving cochlear hair cells and hearing function.

Conclusions
Our systematic review delves into the intricate relationship between DM and hearing impairment in animal models. Future research should focus on targeted therapies to enhance cochlear mitochondrial function, alleviate oxidative stress, and regulate apoptosis. The association between SNHL and social isolation as well as cognitive decline underscores the necessity for innovative therapeutic modalities addressing yet undiscovered mechanisms. Translating findings from animal models to human studies will validate these findings, offering a synergistic approach to effectively manage DM-associated co-morbidities such as hearing impairment.
Sounds Irish, Acts Global: Explaining the Success of Ireland’s Popular Music Industry, Michael Mary Murphy and Jim Rogers (2023)
Authors: Bestley Russ 
Published: July 2024

Review of: Sounds Irish, Acts Global: Explaining the Success of Ireland’s Popular Music Industry, Michael Mary Murphy and Jim Rogers (2023)
Sheffield: Equinox Publishing, 222 pp.,
ISBN 978-1-78179-779-2, h/bk, £70.00
Transfigured New York: Interviews with Experimental Artists and Musicians, 1980-1990, Brooke Wentz (2023)
Authors: Loydell Rupert 
Published: July 2024

Review of: Transfigured New York: Interviews with Experimental Artists and Musicians, 1980-1990, Brooke Wentz (2023)
New York: Columbia University Press, 324 pp.,
ISBN 978-0-23121-088-1, h/bk, £35
Who Cares Anyway: Post-Punk San Francisco and the End of the Analog Age, Will York (2023)
Authors: Sewell John Ike 
Published: July 2024

Review of: Who Cares Anyway: Post-Punk San Francisco and the End of the Analog Age, Will York (2023)
Oxford: Headpress Books, 572 pp.,
ISBN 978-1-91531-609-5, p/bk, £22.99
Successful Treatment of Rituximab-Induced Crohn's Disease With Ustekinumab
Authors: Li Xue Jing , Fung Brian M. , Kumar Rashmi 
Published: July 2024

ABSTRACT
Autoimmune optic papillitis is a rare disorder that causes progressive visual loss, often treated with rituximab (RTX). However, its use is not without risks. Here, we present a 51-year-old man who experienced vision loss because of autoimmune optic papillitis, which was well-controlled with RTX. Four years later, the patient developed abdominal pain and diarrhea and was found to have RTX-induced Crohn's disease (CD). The patient failed treatment with azathioprine, but was subsequently able to achieve clinical and endoscopic remission of his CD with ustekinumab, while continuing RTX therapy for autoimmune optic papillitis. This case report describes the efficacy of the anti-interleukin 12/23 monoclonal antibody in inducing remission of RTX-induced CD.
“We Are All Suffering Equally”: The Impact of the War on Muwalladin in Yemen
Authors: de Regt Marina , Aljaedy Aisha 
Published: July 2024

Abstract
This article focuses on the impact of the war on people of mixed Yemeni-African descent in Yemen. These so-called muwalladin have been the target of discriminatory practices for decades. Since the start of the civil war in Yemen, stigmatization and discrimination on the basis of one's family background has increased. Based on a qualitative study among muwalladin in Yemen we argue that discrimination on the basis of race and gender is highly prevalent in Yemen, even though many interviewees were of the opinion that differences between Yemenis had decreased as a result of the war because “everyone is suffering equally.” Indeed, the daily lives of the Yemeni population are affected on many different levels, yet those who are considered second class citizens based on the intersection of their gender, race, lineage, and skin color, are suffering more than others.
Allelic frequencies of polymorphism c.521T>C (rs4149056) favor preemptive SLCO1B1 genotyping in Armenia
Authors: Németh Stefan , Kriegshäuser Gernot , Hayrapetyan Hasmik , Oberkanins Christian , Sarkisian Tamara 
Published: July 2024

Abstract

Objectives
Statins represent an important pharmacological factor for the prevention of cardiovascular diseases but may also cause severe cases of myotoxicity. Numerous studies have described the association of the SLCO1B1 gene variant c.521C with statin-induced myopathy across different populations. This study aimed at evaluating the usefulness of preemptive SLCO1B1 genotyping in Armenia.

Methods
A total of 202 Armenian patients referred to the Center of Medical Genetics and Primary Health Care in Yerevan for upper respiratory tract infection between January and May 2022 were included in this study. Genotyping for SLCO1B1 c.521T>C (rs4149056) was performed using a commercially available real-time PCR assay (RealFast™).

Results
In total, 3/202 (1.5 %) samples were C/C homozygotes and 52/202 (25.7 %) were T/C heterozygotes, associated with a high and increased risk for statin-induced myopathy, respectively. The SLCO1B1 c.521C allelic frequency was 14.4 %.

Conclusions
The observed allele frequency of 14.4 % for the c.521C variant is slightly lower than frequencies reported from Europe, but relatively high compared to Asian populations, suggesting that preemptive SLCO1B1 genotyping could be a useful approach for the reduction of statin-induced adverse effects in Armenia.
Highly sensitive volumetric single-molecule imaging
Authors: Wang Le-Mei , Kim Jiah , Han Kyu Young 
Published: July 2024

Abstract
Volumetric subcellular imaging has long been essential for studying structures and dynamics in cells and tissues. However, due to limited imaging speed and depth of field, it has been challenging to perform live-cell imaging and single-particle tracking. Here we report a 2.5D fluorescence microscopy combined with highly inclined illumination beams, which significantly reduce not only the image acquisition time but also the out-of-focus background by ∼2-fold compared to epi-illumination. Instead of sequential z-scanning, our method projects a certain depth of volumetric information onto a 2D plane in a single shot using multi-layered glass for incoherent wavefront splitting, enabling high photon detection efficiency. We apply our method to multi-color immunofluorescence imaging and volumetric super-resolution imaging, covering ∼3–4 µm thickness of samples without z-scanning. Additionally, we demonstrate that our approach can substantially extend the observation time of single-particle tracking in living cells.
Fünf noch unveröffentlichte Briefe Friedrich Nietzsches
Authors: Jung Joachim , Carbone Mirella 
Published: July 2024

Abstract

Five Unpublished Letters by Friedrich Nietzsche. Five unpublished letters by Nietzsche to Louise Röder-Wiederhold, as well as an unknown letter (draft) from her own hand suggest that Nietzsche’s negative judgment of her, which has dominated biographical Nietzsche research up to now, was anything but definitive and can be strongly relativized. The new documents also prove that Röder-Wiederhold was not only a temporary “secretary” for Nietzsche, but also an intellectual and humorous, interested, compassionate and independent-thinking correspondence partner, even if she did not enter into a closer friendship with him. What particularly connected the two and remained an almost constant theme of their correspondence was the difficult life situation of their mutual friend, the unsuccessful composer Heinrich Köselitz, and how one could help him to get access to orchestras and opera stages in German-speaking countries which might perform his works.
Optimizing execution time and cost while scheduling scientific workflow in edge data center with fault tolerance awareness
Authors: Kadum Muhanad Mohammed , Deng Xiaoheng 
Published: July 2024

Abstract
Scheduling scientific workflows is essential for edge data centers operations. Fault tolerance is a crucial focus in workflow scheduling (WS) research. This study proposed fault-tolerant WS in edge data centers using Task Prioritization Adaptive Particle Swarm Optimization (TPAPSO). The aim is to minimize the Makespan, execution costs, and overcoming failures at all workflow processing stages, including when virtual machines are insufficient or tasks fail. The approach proposes three components: initial heuristic list, scheduling tasks with TPAPSO, and implementing performance monitoring with fault tolerance (PMWFT). TPAPSO-PMWFT is simulated using CloudSim 4.0. The experiments indicate that the suggested approach shows superior results compared to existing methods.
New half sandwich complexes of ruthenium(ii) and iridium(iii). Study of their toxicity against Hela
Authors: Canales-Martínez Alfonso , Pérez-Pastor Rosa M. , García Gabriel 
Published: July 2024

Abstract
In this work, we describe the synthesis and characterisation of the starting materials [Cp*IrCl2]2 and four new ruthenium(II) and iridium(III) complexes half sandwich, contain the fragments [(p-cymene)Ru]2+ and [Cp*Ir]2+; (Cp* = CpMe4Et) of stoichiometry: [Cp*IrCl2(2-aminopyridine)] (I), [Cp*IrCl2(4-aminopyridine)] (II), [Cp*IrCl2(adenine)] (III) and [(p-cymene)RuCl2(adenine)] (IV). The new compounds have been characterised by C, H, and N elemental analysis; infrared and 1H NMR spectroscopy with 1H–1H COSY, ESI/TOF mass spectrometry and thermogravimetry. A study of the cytotoxicity of these compounds against the Hela cell line was carried out, with results indicating a low activity.
Renewable carbon resource from biomass: building molecular architectures from furanic platforms
Authors: López Gloria V. , Porcal Williams 
Published: July 2024

Abstract
Currently, we find ourselves with the urgent need for chemistry to exert a substantial positive influence on environmental impact, by means of products and chemical processes. To achieve these objectives, we must pay special attention in terms of resource sustainability, considering factors such as life cycle assessments and minimizing carbon footprints. Biomass obtained from organic matter found in plants as well as agricultural and industrial waste, represents the most abundant reserve of renewable materials on our planet. In this perspective we highlight the research and innovation possibilities provided by renewable raw materials obtained from biomass within the domain of organic synthesis toward sustainable development. We focus our discussion on different reactions in the field of organic chemistry, primarily employing furanic platforms as renewable compounds derived from cellulosic biomass. The main aim is to generate high-value products, with a special emphasis on potential development of new pharmaceuticals.
A Regression-based Method for Estimating Generalised Entropy and Atkinson Inequality Indices and their Standard Errors
Authors: Shankar Sriram 
Published: July 2024

Abstract
In this paper we show that a regression-based approach can be used to estimate generalised entropy and Atkinson inequality indices and their associated standard errors. The applicability of this approach is demonstrated using the health expenditure data from the United States (US) medical expenditure panel survey (MEPS).
Acute ischemic STROKE – from laboratory to the Patient’s BED (STROKELABED): A translational approach to reperfusion injury. Study Protocol
Authors: Sodero Alessandro , Conti Emilia , Piccardi Benedetta , Sarti Cristina , Palumbo Vanessa , Kennedy James , Gori Anna Maria , Giusti Betti , Fainardi Enrico , Nencini Patrizia , Allegra Mascaro Anna Letizia , Pavone Francesco Saverio , Baldereschi Marzia 
Published: July 2024

Abstract
Cerebral edema (CE) and hemorrhagic transformation (HT) are frequent and unpredictable events in patients with acute ischemic stroke (AIS), even when an effective vessel recanalization has been achieved. These complications, related to blood-brain barrier (BBB) disruption, remain difficult to prevent or treat and may offset the beneficial effect of recanalization, and lead to poor outcomes. The aim of this translational study is to evaluate the association of circulating and imaging biomarkers with subsequent CE and HT in stroke patients with the dual purpose of investigating possible predictors as well as molecular dynamics underpinning those events and functional outcomes. Concurrently, the preclinical study will develop a new mouse model of middle cerebral artery (MCA) occlusion and recanalization to explore BBB alterations and their potentially harmful effects on tissue. The clinical section of the study is based on a single-center observational design enrolling consecutive patients with AIS in the anterior circulation territory, treated with recanalization therapies from October 1, 2015 to May 31, 2020. The study will employ an innovative evaluation of routine CT scans: in fact, we will assess and quantify the presence of CE and HT after stroke in CT scans at 24 h, through the quantification of anatomical distortion (AD), a measure of CE and HT. We will investigate the relationship of AD and several blood biomarkers of inflammation and extracellular matrix, with functional outcomes at 3 months. In parallel, we will employ a newly developed mouse model of stroke and recanalization, to investigate the emergence of BBB changes 24 h after the stroke onset. The close interaction between clinical and preclinical research can enhance our understanding of findings from each branch of research, enabling a deeper interpretation of the underlying mechanisms of reperfusion injury following recanalization treatment for AIS.
GEOCHEMISTRY OF CRUDE OILS FROM THE BAZHENOV HORIZON (WEST SIBERIA)
Authors: ФУРСЕНКО Е.А. , КОНТОРОВИЧ А.Э. , КОСТЫРЕВА Е.А. , ПАДАЛКО Н.Л. , РОДЧЕНКО А.П. , РЫЖКОВА С.В. 
Published: July 2024

Баженовский горизонт является основной нефтепроизводящей толщей Западно-Сибирской нефтегазоносной провинции, в которой одновременно аккумулированы значительные ресурсы трудноизвлекаемого углеводородного сырья, что делает эту толщу уникальным объектом для исследований. В работе обобщена геохимическая информация о нефтях (39 проб) из залежей в баженовской и тутлеймской свитах. Сравнительный анализ изотопного состава углерода и геохимических показателей, рассчитанных по составу идентифицированных насыщенных и ароматических соединений (пристан/ фитан, стераны С29/С27, гомогопаны С35/С34, трициклановый индекс, относительные концентрации дибензтиофенов), подтверждают единый аквагенный генотип исследованных нефтей и их генетическое родство с одновозрастным органическим веществом. Вместе с тем, отмечается широкий диапазон изменения базовых физико-химических характеристик исследованных баженовских нефтей, которые обусловлены влиянием их фракционирования в ходе миграционных процессов.
The Bazhenov horizon is the main source rock stratum of the West Siberian petroleum province, which possesses significant resources of hard-to-recover hydrocarbons, making it a unique exploration target. The study summarizes geochemical data on crude oils (39 samples) collected from pools within the Bazhenov and Tutleima formations. A comparative analysis of the carbon isotope composition and geochemical parameters calculated from the composition of the identified saturated and aromatic compounds (pristane/phytane, C29/C27 steranes, C35/C34 homohopanes, tricyclane index, relative concentrations of dibenzothiophenes) confirm a common aquatic genotype of the studied oils and their genetic affinity to the organic matter of the same age. At the same time, significant variations in the main physical and chemical characteristics of the studied Bazhenov oils may be caused their fractionation during migration processes.
TOPICAL ISSUES OF PETROLEUM GEOLOGY (90TH BIRTHDAY OF ACADEMICIAN A.E. KONTOROVICH)
Authors: БУРШТЕЙН Л.М. , КОНТОРОВИЧ В.А. 
Published: July 2024

Данный выпуск журнала посвящен 90-летию академика РАН А.Э. Конторовича. Во вводной статье приведен обзор вошедших в него материалов. Тематика статей тесно связана с научными интересами Алексея Эмильевич, хотя и не исчерпывает их в полной мере. Юбилейный выпуск включает статьи, затрагивающие актуальные вопросы строения, тектоники, стратиграфии, нефтегазоносности и различные аспекты и характеристики геохимии нефтей и органического вещества нефтегазопроизводящих формаций осадочнопородных бассейнов Сибири и Арктики. Среди множества направлений, которыми занимался А.Э. Конторович, была геология и геохимия концентрированных форм ископаемого органического вещества – углей. Поэтому логично, что настоящий специальный выпуск завершает статья, посвященная исследованию древнейших, девонских углей.
This issue of the journal is dedicated to the 90th birthday of Academician of the RAS A.E. Kontorovich. This introductory article reviews the included materials. The topics of the articles are closely connected to the scientific interests of Aleksei Emilievich, even though they are not fully represented. This anniversary issue includes articles concerning topical questions of geology, tectonics, stratigraphy, petroleum potential, as well as various aspects and characteristics of oil and organic matter geochemistry in oil-and-gas source formations of sedimentary basins of Siberia and the Arctic. Among the many lines of research A.E. Kontorovich pursued was the geology and geochemistry of concentrated forms of subsoil organic matter – coal. Therefore, this issue logically ends with an article on the study of the most ancient Devonian coals.
GROWTH OF LARCH CROPS ON CRYOLOTHOZONE YAKUTIA
Authors: ГАБЫШЕВА Л.П. , ИСАЕВ А.П. 
Published: July 2024

В статье рассмотрены вопросы искусственного лесовосстановления на гарях в условиях криолитозоны Якутии. Научно обоснованных работ по лесным культурам в Якутии до настоящего времени не было. Подведены итоги многолетних наблюдений за лиственничными культурами, заложенными на территории Мегино-Кангаласского лесничества Республики Саха (Якутия). Искусственное лесовосстановление проведено саженцами лиственницы Каяндера ( Larix cajanderi Mayr) с открытой корневой системой. Проанализированы зафиксированные в разных источниках опыт создания, а также рост и развитие лесных культур лиственницы, дана оценка приживаемости за 20 лет. Выявлено, что в первые годы после посадки, в период адаптации к новым условиям среды, темпы роста саженцев низкие, а через 3-4 года они увеличиваются, и в 15-20 лет отмечается их максимальный рост. Приведена характеристика живого напочвенного покрова на участке искусственного лесовосстановления и на контроле. Прослежены существенные изменения в растительности: ее трансформация с преимущественно лугово-разнотравной в лесную. Материалы статьи могут стать основой для разработки перспективных технологий лесовосстановления в условиях криолитозоны и позволят добиться качественного восстановления лесов при проведении работ по искусственному и комбинированному лесовосстановлению в свете последних изменений в лесном законодательстве.
The article deals with the issues of artificial reforestation on the burnt areas in the permafrost zone of East Siberia (Yakutia). Scientifically substantiated work on forest plantations in Yakutia has not been carried out before this work. The results of long-term observations of larch crops, which were carried out on the territory of the Megino-Kangalassky forestry of the Republic of Sakha (Yakutia), are summed up. Artificial reforestation was carried out with of Kayander larch ( Larix cajanderi Mayr) seedlings. The article also presents and analyzes all the experiences of creating forest plantations recorded in various sources, carried out in the republic in different years. An analysis of the growth and development of larch plantation is given, an estimate of survival rate for 8 years is given. In the first years after planting, seedlings adapt to new environmental conditions, starting from the third or fourth year after planting, there is an increasing growth of seedlings, and from 15-20 years, the growth of larch crops is intensified. The characteristics of the vegetation in the area of artificial reforestation and in the control are given. For twenty years, significant changes in the vegetation cover have been traced: from meadow-forb to forest vegetation. The materials of the article can be the basis for the development of the most promising technologies for reforestation in the permafrost zone and will make it possible to achieve high-quality reforestation during artificial and combined reforestation in the light of recent changes in forest legislation.
On the interaction between vowel confusions (<e> for /i/ and <o> for /u/) and lexical stress in Latin inscriptions from Rome (ca. 119 BCE – ca. 600 CE)
Authors: Papini Alessandro 
Published: July 2024

AbstractThe aim of this article is to better define how changes in the Latin vowel system evolved over time in the stressed vs. the unstressed syllables in the Latin of Rome. To this end, the cases of <e> for /i/ and <o> for /u/ in an epigraphic corpus of 6,599 inscriptions from this city have been analysed by comparing the number of epigraphic errors occurring under and out of stress in five different periods. Our results indicate that, until about the 4th cent. CE, cases of <e> for /i/ and <o> for /u/ occur mostly in the unstressed syllables in our inscriptions, which is consistent with the view that the reorganisation of the vocalic qualities in the Latin vowel system affected the unstressed vowels before it affected the stressed ones. However, the same results also indicate that the number of epigraphic deviations concerning the stressed vowels /i/ and /u/ in our corpus increases from about the 4th–5th cent. CE onwards, and that this fact should be linked to the dephonologisation of contrastive vowel quantity (in the stressed syllables).