bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Organizational Culture According to Hofstede Model on Information Technology Acceptance in Hospital Environment
Authors: Tabibi Seyed Jamaledin , Nasiripour Amir Ashkan , Kazemzadeh Reza Baradaran , Ebrahimi Parvin 
Published: March 2015

The effect of information systems on organizational performance is dependent on the users’ acceptance. Some researchers suppose that organizational culture can be one of the involving factors in successful implementation of information systems. The purpose of this study was to examine the role of Hofstede organizational culture on the acceptance of hospital information system by its users in non-teaching hospitals of Iran University of Medical Sciences. This research was applicable and was done by using descriptive and analytical methods. The conceptual model was proposed according to the related literature. The questionnaire was developed based on the model variables; then it was validated by expert panel and content validity ratio and its reliability was tested by calculating Cronbach’s alpha. The questionnaires were delivered among 400 users of HIS in the studied hospitals. To test the model fitness, structural equation modelling method was used by applying LISREL software. The normed chi-square index (2.01) showed that the research model has fitness with the gathered data. The indices included: GFI = 0.99, CFI = 0.99, AGFI = 0.96, RMSEA = 0.051. According to the research model, the relationship between two aspects of Hofstede organizational culture (process/results-oriented and open/closed systems) and HIS acceptance variables was statistically significant. The results showed that process/results-oriented culture was related to user satisfaction, and also open/closed system was correlated with three variables, including perceived ease of use, subjective norms and user satisfaction.
Factors associated with optimized tacrolimus dosing in hematopoietic stem cell transplantation
Authors: Butts Allison R , Brown Victoria T , McBride Lauren D , Bolaños-Meade Javier , Bryk Amy W 
Published: March 2015

Objective The primary objective was to analyze the initial tacrolimus concentrations achieved in allogeneic hematopoietic stem cell transplantation patients using the institutional dosing strategy of 1 mg IV daily initiated on day +5. The secondary objectives were to ascertain the tacrolimus dose, days of therapy, and dose changes necessary to achieve a therapeutic concentration, and to identify patient-specific factors that influence therapeutic dose. The relationships between the number of pre-therapeutic days and incidence of graft-versus-host disease and graft failure were delineated. Methods A retrospective chart review included adult allogeneic hematopoietic stem cell patients who received tacrolimus for graft-versus-host disease prophylaxis in 2012. Descriptive statistics, linear and logistic regression, and graphical analyses were utilized. Results Ninety-nine patients met the inclusion criteria. The first concentration was subtherapeutic (<10 ng/ml) in 97 patients (98%). The median number of days of tacrolimus needed to achieve a therapeutic trough was 10 with a median of two dose changes. The median therapeutic dose was 1.6 mg IV daily. Approximately 75% of patients became therapeutic on ≤ 2 mg IV tacrolimus daily. No relationship was found between therapeutic dose and any patient-specific factor tested, including weight. No relationship was found between the number of days of therapy required to achieve a therapeutic trough and incidence of graft-versus-host disease or graft failure. Conclusion An initial flat tacrolimus dose of 1 mg IV daily is a suboptimal approach to achieve therapeutic levels at this institution. A dose of 1.6 mg or 2 mg IV daily is a reasonable alternative to the current institutional practice.
PD-L1 checkpoint blockade prevents immune dysfunction and leukemia development in a mouse model of chronic lymphocytic leukemia
Authors: McClanahan Fabienne , Hanna Bola , Miller Shaun , Clear Andrew James , Lichter Peter , Gribben John G. , Seiffert Martina 
Published: March 2015

Key PointsIn vivo PD-L1 blockade prevents CLL development in the Eµ-TCL1 adoptive transfer model. In vivo PD-L1 blockade normalizes T-cell and myeloid cell populations and immune effector functions.
Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming
Authors: Iqbal Khursheed , Tran Diana A , Li Arthur X , Warden Charles , Bai Angela Y , Singh Purnima , Wu Xiwei , Pfeifer Gerd P , Szabó Piroska E 
Published: March 2015

Abstract
Background
Exposure to environmental endocrine-disrupting chemicals during pregnancy reportedly causes transgenerationally inherited reproductive defects. We hypothesized that to affect the grandchild, endocrine-disrupting chemicals must alter the epigenome of the germ cells of the in utero-exposed G1 male fetus. Additionally, to affect the great-grandchild, the aberration must persist in the germ cells of the unexposed G2 grandchild.

Results
Here, we treat gestating female mice with vinclozolin, bisphenol A, or di-(2-ethylhexyl)phthalate during the time when global de novo DNA methylation and imprint establishment occurs in the germ cells of the G1 male fetus. We map genome-wide features in purified G1 and G2 prospermatogonia, in order to detect immediate and persistent epigenetic aberrations, respectively. We detect changes in transcription and methylation in the G1 germline immediately after endocrine-disrupting chemicals exposure, but changes do not persist into the G2 germline. Additional analysis of genomic imprints shows no persistent aberrations in DNA methylation at the differentially methylated regions of imprinted genes between the G1 and G2 prospermatogonia, or in the allele-specific transcription of imprinted genes between the G2 and G3 soma.

Conclusions
Our results suggest that endocrine-disrupting chemicals exert direct epigenetic effects in exposed fetal germ cells, which are corrected by reprogramming events in the next generation. Avoiding transgenerational inheritance of environmentally-caused epigenetic aberrations may have played an evolutionary role in the development of dual waves of global epigenome reprogramming in mammals.
Coordinated international action to accelerate genome-to-phenome with FAANG, the Functional Annotation of Animal Genomes project
Authors:   The FAANG Consortium, Andersson Leif , Archibald Alan L , Bottema Cynthia D , Brauning Rudiger , Burgess Shane C , Burt Dave W , Casas Eduardo , Cheng Hans H , Clarke Laura , Couldrey Christine , Dalrymple Brian P , Elsik Christine G , Foissac Sylvain , Giuffra Elisabetta , Groenen Martien A , Hayes Ben J , Huang LuSheng S , Khatib Hassan , Kijas James W , Kim Heebal , Lunney Joan K , McCarthy Fiona M , McEwan John C , Moore Stephen , Nanduri Bindu , Notredame Cedric , Palti Yniv , Plastow Graham S , Reecy James M , Rohrer Gary A , Sarropoulou Elena , Schmidt Carl J , Silverstein Jeffrey , Tellam Ross L , Tixier-Boichard Michele , Tosser-Klopp Gwenola , Tuggle Christopher K , Vilkki Johanna , White Stephen N , Zhao Shuhong , Zhou Huaijun 
Published: March 2015

AbstractWe describe the organization of a nascent international effort, the Functional Annotation of Animal Genomes (FAANG) project, whose aim is to produce comprehensive maps of functional elements in the genomes of domesticated animal species.
An external validation study reporting poor correlation between the claims-based index for rheumatoid arthritis severity and the disease activity score
Authors: Desai Rishi J , Solomon Daniel H , Weinblatt Michael E , Shadick Nancy , Kim Seoyoung C 
Published: March 2015

Abstract
Introduction
We conducted an external validation study to examine the correlation of a previously published claims-based index for rheumatoid arthritis severity (CIRAS) with disease activity score in 28 joints calculated by using C-reactive protein (DAS28-CRP) and the multi-dimensional health assessment questionnaire (MD-HAQ) physical function score.

Methods
Patients enrolled in the Brigham and Women’s Hospital Rheumatoid Arthritis Sequential Study (BRASS) and Medicare were identified and their data from these two sources were linked. For each patient, DAS28-CRP measurement and MD-HAQ physical function scores were extracted from BRASS, and CIRAS was calculated from Medicare claims for the period of 365 days prior to the DAS28-CRP measurement. Pearson correlation coefficient between CIRAS and DAS28-CRP as well as MD-HAQ physical function scores were calculated. Furthermore, we considered several additional pharmacy and medical claims-derived variables as predictors for DAS28-CRP in a multivariable linear regression model in order to assess improvement in the performance of the original CIRAS algorithm.

Results
In total, 315 patients with enrollment in both BRASS and Medicare were included in this study. The majority (81%) of the cohort was female, and the mean age was 70 years. The correlation between CIRAS and DAS28-CRP was low (Pearson correlation coefficient = 0.07, P = 0.24). The correlation between the calculated CIRAS and MD-HAQ physical function scores was also found to be low (Pearson correlation coefficient = 0.08, P = 0.17). The linear regression model containing additional claims-derived variables yielded model R2 of 0.23, suggesting limited ability of this model to explain variation in DAS28-CRP.

Conclusions
In a cohort of Medicare-enrolled patients with established RA, CIRAS showed low correlation with DAS28-CRP as well as MD-HAQ physical function scores. Claims-based algorithms for disease activity should be rigorously tested in distinct populations in order to establish their generalizability before widespread adoption.
Co-morbidity and systemic inflammation as drivers of cognitive decline: new experimental models adopting a broader paradigm in dementia research
Authors: Cunningham Colm , Hennessy Edel 
Published: March 2015

AbstractDementia prevalence increases with age and Alzheimer’s disease (AD) accounts for up to 75% of cases. However, significant variability and overlap exists in the extent of amyloid-β and Tau pathology in AD and non-demented populations and it is clear that other factors must influence progression of cognitive decline, perhaps independent of effects on amyloid pathology. Coupled with the failure of amyloid-clearing strategies to provide benefits for AD patients, it seems necessary to broaden the paradigm in dementia research beyond amyloid deposition and clearance. Evidence has emerged from alternative animal model approaches as well as clinical and population epidemiological studies that co-morbidities contribute significantly to neurodegeneration/cognitive decline and systemic inflammation has been a strong common theme in these approaches. We hypothesise, and discuss in this review, that a disproportionate inflammatory response to infection, injury or chronic peripheral disease is a key determinant of cognitive decline. We propose that detailed study of alternative models, which encompass acute and chronic systemic inflammatory co-morbidities, is an important priority for the field and we examine the cognitive consequences of several of these alternative experimental approaches. Experimental models of severe sepsis in normal animals or moderate acute systemic inflammation in animals with existing neurodegenerative pathology have uncovered roles for inflammatory mediators interleukin-1β, tumour necrosis factor-α, inducible nitric oxide synthase, complement, prostaglandins and NADPH oxidase in inflammation-induced cognitive dysfunction and neuronal death. Moreover, microglia are primed by existing neurodegenerative pathology to produce exaggerated responses to subsequent stimulation with bacterial lipopolysaccharide or other inflammatory stimuli and these insults drive acute dysfunction and negatively affect disease trajectory. Chronic co-morbidities, such as arthritis, atherosclerosis, obesity and diabetes, are risk factors for subsequent dementia and those with high inflammatory status are particularly at risk. Models of chronic co-morbidities, and indeed low grade systemic inflammation in the absence of specific pathology, indicate that interleukin-1β, tumour necrosis factor-α and other inflammatory mediators drive insulin resistance, hypothalamic dysfunction, impaired neurogenesis and cognitive function and impact on functional decline. Detailed study of these pathways will uncover important mechanisms of peripheral inflammation-driven cognitive decline and are already driving clinical initiatives to mitigate AD progression through minimising systemic inflammation.
Long-Term Survival Advantage and Prognostic Factors Associated With Intraperitoneal Chemotherapy Treatment in Advanced Ovarian Cancer: A Gynecologic Oncology Group Study
Authors: Tewari Devansu , Java James J. , Salani Ritu , Armstrong Deborah K. , Markman Maurie , Herzog Thomas , Monk Bradley J. , Chan John K. 
Published: March 2015

PurposeTo determine long-term survival and associated prognostic factors after intraperitoneal (IP) chemotherapy in patients with advanced ovarian cancer.Patients and MethodsData from Gynecologic Oncology Group protocols 114 and 172 were retrospectively analyzed. Cox proportional hazards regression models were used for statistical analyses.ResultsIn 876 patients, median follow-up was 10.7 years. Median survival with IP therapy was 61.8 months (95% CI, 55.5 to 69.5), compared with 51.4 months (95% CI, 46.0 to 58.2) for intravenous therapy. IP therapy was associated with a 23% decreased risk of death (adjusted hazard ratio [AHR], 0.77; 95% CI, 0.65 to 0.90; P = .002). IP therapy improved survival of those with gross residual (≤ 1 cm) disease (AHR, 0.75; 95% CI, 0.62 to 0.92; P = .006). Risk of death decreased by 12% for each cycle of IP chemotherapy completed (AHR, 0.88; 95% CI, 0.83 to 0.94; P < .001). Factors associated with poorer survival included: clear/mucinous versus serous histology (AHR, 2.79; 95% CI, 1.83 to 4.24; P < .001), gross residual versus no visible disease (AHR, 1.89; 95% CI, 1.48 to 2.43; P < .001), and fewer versus more cycles of IP chemotherapy (AHR, 0.88; 95% CI, 0.83 to 0.94; P < .001). Younger patients were more likely to complete the IP regimen, with a 5% decrease in probability of completion with each year of age (odds ratio, 0.95; 95% CI, 0.93 to 0.96; P < .001).ConclusionThe advantage of IP over intravenous chemotherapy extends beyond 10 years. IP therapy enhanced survival of those with gross residual disease. Survival improved with increasing number of IP cycles.
Evaluation of a Pharmacist-Led Medication Assessment Used to Identify Prevalence of and Associations With Polypharmacy and Potentially Inappropriate Medication Use Among Ambulatory Senior Adults With Cancer
Authors: Nightingale Ginah , Hajjar Emily , Swartz Kristine , Andrel-Sendecki Jocelyn , Chapman Andrew 
Published: March 2015

Purpose The use of multiple and/or inappropriate medications in seniors is a significant public health problem, and cancer treatment escalates its prevalence and complexity. Existing studies are limited by patient self-report and medical record extraction compared with a pharmacist-led comprehensive medication assessment. Patients and Methods We retrospectively examined medication use in ambulatory senior adults with cancer to determine the prevalence of polypharmacy (PP) and potentially inappropriate medication (PIM) use and associated factors. PP was defined as concurrent use of five or more and less than 10 medications, and excessive polypharmacy (EPP) was defined as 10 or more medications. PIMs were categorized by 2012 Beers Criteria, Screening Tool of Older Person's Prescriptions (STOPP), and the Healthcare Effectiveness Data and Information Set (HEDIS). Results A total of 248 patients received a geriatric oncology assessment between January 2011 and June 2013 (mean age was 79.9 years, 64% were women, 74% were white, and 87% had solid tumors). Only 234 patients (evaluated by pharmacists) were included in the final analysis. Mean number of medications used was 9.23. The prevalence of PP, EPP, and PIM use was 41% (n = 96), 43% (n = 101), and 51% (n = 119), respectively. 2012 Beers, STOPP, and HEDIS criteria classified 173 occurrences of PIMs, which were present in 40%, 38%, and 21% of patients, respectively. Associations with PIM use were PP (P < .001) and increased comorbidities (P = .005). Conclusion A pharmacist-led comprehensive medication assessment demonstrated a high prevalence of PP, EPP, and PIM use. Medication assessments that integrate both 2012 Beers and STOPP criteria and consider cancer diagnosis, prognosis, and cancer-related therapy are needed to optimize medication use in this population.
Long-Term Continuous Suppression With Once-Yearly Histrelin Subcutaneous Implants for the Treatment of Central Precocious Puberty: A Final Report of a Phase 3 Multicenter Trial
Authors: Silverman Lawrence A. , Neely E. Kirk , Kletter Gad B. , Lewis Katherine , Chitra Surya , Terleckyj Oksana , Eugster Erica A. 
Published: March 2015

Context and Objective:
The histrelin implant has proven to be an effective method of delivering GnRH analog (GnRHa) therapy to children with central precocious puberty (CPP), yet there are limited data available regarding hormonal suppression and auxological changes during an extended course of therapy.

Design:
This was a phase 3, prospective, open-label study.

Setting and Participants:
Thirty-six children with CPP who participated in a phase 3, open-label study and required further GnRHa therapy were eligible to continue treatment receiving a new implant upon removal of the prior 12-month histrelin implant during a long-term extension phase.

Outcome Measures:
Hormone levels and auxologic parameters were measured periodically for up to 6 years of treatment and up to 1 year of posttreatment follow-up.

Results:
Hormonal suppression was maintained throughout the study in patients who had prior GnRHa therapy (n = 16) and in treatment-naive patients (n = 20). Bone age to chronological age ratio decreased from 1.417 (n = 20) at baseline to 1.18 (n = 8) at 48 months in treatment-naive children (P &lt; .01). Predicted adult height in girls increased from 151.9 cm at baseline to 166.5 cm at month 60 (n = 6; P &lt; .05), with a 10.7-cm height gain observed among treatment-naive children (n = 5). No adverse effect on growth or recovery of the hypothalamic-pituitary-gonadal axis was observed with hormonal suppression. The histrelin implant was generally well tolerated during long-term therapy.

Conclusions:
Long-term histrelin implant therapy provided sustained gonadotropin suppression safely and effectively and improved predicted adult height in children with CPP.
“This Marvelous Bean”: Adopting Coffee into Old Regime French Culture and Diet
Authors: Landweber Julia 
Published: March 2015

This article examines coffee’s adoption into French culture and diet between 1644 and 1788, emphasizing the period 1670–1730. In these sixty years, a beverage initially mistrusted by the French (for its bitterness, health risks, and associations with the Ottoman Empire) became a beloved beverage, gave its name to the new space of the café, and attracted a burgeoning culture of consumers interested in exotic novelties. Through a focus on coffee, we gain fresh insights into a number of disparate subjects, including the evolving cultural relationship between France and the Ottoman Empire; shifts in the sociability structures of the urban middling classes, from socializing around alcohol to the promotion of sobering stimulants; the developing role of merchants, physicians, and pharmacists in assessing the safety of new foodstuffs; the rise of cuisine moderne, with its openness to new ingredients; and the birth of a global French coffee trade in the eighteenth century.
Cet essai examine l’adoption du café dans la culture française entre 1644 et 1788. Dans ces années, une boisson dont se méfiaient les Français (pour son amertume, les risques sanitaires et les associations avec l’Empire ottoman) est devenue une boisson bien-aimée, qui a donné son nom au nouvel espace du café, et a attiré une culture en plein essor de consommateurs intéressés par les nouveautés exotiques. Cette histoire offre des idées nouvelles sur plusieurs sujets, y compris la relation culturelle en évolution entre la France et l’Empire ottoman; les changements dans les structures de sociabilité des classes moyennes urbaines; le passage de la socialisation autour de l’alcool à la promotion des stimulants qui donne à réfléchir; le rôle croissant des commerçants, des médecins et des pharmaciens dans l’évaluation de l’innocuité des nouveaux produits alimentaires; la montée de la cuisine moderne, et la naissance d’un commerce mondial autour du café français au dix-huitième siècle.
Effective simulation of quantum entanglement using classical fields modulated with pseudorandom phase sequences
Authors: Fu Jian , Wu Xingkun 
Published: March 2015

Abstract
An effective simulation of quantum entanglement is presented using classical fields modulated with n pseudorandom phase sequences that constitute a n2
n
-dimensional Hilbert space with a tensor product structure. Applications to classical fields are examplied by effective simulation of both Bell and GHZ states, and a correlation analysis was performed to characterize the simulation. Results that strictly comply with criteria of quantum entanglement were obtained and the approach was also shown to be applicable to a system consisting of n quantum particles.
Nurse Practitioners and Their Effects on Visits to Primary Care Physicians
Authors: Pylypchuk Yuriy , Sarpong Eric M 
Published: March 2015

Abstract
The demand for primary care services is expected to increase at a time of persistent shortages of primary care physicians (PCPs) in the United States. A proposed solution is to expand the role of other allied health professions. This study examines the causal effects of visits to nurse practitioners (NPs) on the demand for services from PCPs. We employ a system of simultaneous equations and dynamic panel estimators to control for endogeneity of visits to NPs. Results indicate that patients who visited an NP are significantly less likely to visit PCPs and to receive prescribed medication, medical check-up, and diagnosis from PCPs. Findings were robust to other specification and passed a falsification test. The results suggest that the use of NPs could serve as a potential option to address shortages in supply of primary care services.
Crystallographic and structural characterization
of heterometalic platinum complexes
Part X. Heteropolynuclear pt complexes
Authors: Melník Milan , Mikuš Peter , Holloway Clive E. 
Published: March 2015

Abstract
This review covers heteropolynuclear platinum
complexes. There are over sixty examples with heterometal
atoms as partners including non- transition metals, K, Cs,
Mg, Ca, Sr, Tl, Sn, Pb, Zn, Cd, and transition metals: Cu,
Ag, Fe, Co, Ni, Rh and Pd. In addition, there are examples
for the lanthanides, Eu and Yb. The most common are Ag
(x16) and K (x14). The predominant geometries for Pt(II)
is square-planar and for Pt(IV) is octahedral. The overall
structures are complex. In spite of the wide variety of
heterometal atoms partners of platinum, there is “real”
Pt-M bonds only with silver, ranging from 2.678 to 2.943(I)
Å (ave 2.855 Å). The mean Pt-Pt bond distance is 2.869 Å.