bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunohistochemical detection of Helicobacter pylori without association of TLR5 expression in oral squamous cell carcinoma
Authors: Grimm Martin , Munz Adelheid , Exarchou Alexandros , Polligkeit Joachim , Reinert Siegmar 
Published: May 2013

BackgroundApproximately 15% of human deaths from cancer are associated with chronic viral or bacterial infections. Helicobacter pylori (HP), a flagellated, Gram‐negative, spiral, microaerophilic bacteria is considered to be the most common chronic bacterial infection in humans. Toll‐like receptor 5 (TLR5) is involved in recognition of bacterial flagella and is thought to promote tumour growth through inflammation‐dependent mechanisms in epithelial cells.MethodsExpression of HP and TLR5 was analysed in OSCC specimen (n = 191) by immunohistochemistry. TLR5 expression specificity was conducted by Western blotting in cancer cell lines (BICR3, BICR56). TLR5‐stained sections were scanned and digitally analysed using ImageJ and the immunomembrane plug‐in. HP expression and TLR5 expression were associated with clinicopathological characteristics and impact on survival.ResultsHelicobacter pylori detection was significantly associated with recurrence of the tumour, whereas TLR5 expression was not. Multivariate analysis demonstrated HP expression as an independent prognostic factor (P = 0.0260). TLR5 specificity was confirmed by Western blot analysis.ConclusionsFor the first time, this study provides evidence that immunohistochemically detected HP expression in OSCC is associated with reduced disease‐free survival in a large patient cohort. Although TLR5 was not associated with any clinicopathological characteristics or impact on survival, investigation of the TLR family seems to be reasonable due to the possible existence of other pathogenic bacterial or viral compounds in oral cavity cancer.
The Association Between Peer and Own Aggression is Moderated by the BDNF Val‐Met Polymorphism
Authors: Kretschmer Tina , Vitaro Frank , Barker Edward D. 
Published: May 2013

Peer antisocial behavior robustly predicts adolescents' own behavior, but not all adolescents are equally vulnerable to their peers' influence and genetic factors may confer vulnerability. This study used data of n = 3,081 adolescents from the Avon Longitudinal Study of Parents and Children to examine whether brain‐derived neurotrophic factor (BDNF), a polymorphism that affects psychological functioning, moderates the association between affiliation with aggressive peers at age 10 and own aggression at age 15. A significant gene–environment interaction was found, where those who affiliated with aggressive peers in childhood showed increased risk of being aggressive in adolescence if they carried the BDNF met‐met variant compared with val‐val carriers. Our findings underline the importance of both biological and social factors for adolescent development.
Promoting mother–infant interaction and infant mental health in low‐income Korean families: Attachment‐based cognitive behavioral approach
Authors: Lee Gyungjoo , McCreary Linda , Breitmayer Bonnie , Kim Mi Ja , Yang Soo 
Published: May 2013

AbstractPurposeThis study evaluated the attachment‐based cognitive behavioral approach (ACBA) to enhance mother–infant interaction and infant mental health.Design and MethodsThis quasi‐experimental study used a pre‐posttest control group design. Participants were 40 low‐income, mother–infant (infant ages 12–36 months) dyads, 20 dyads per group. The ACBA group received 10 weekly 90‐min sessions. Dependent variables were changes in mother–infant interaction and infant mental health. Additionally, we explored changes in mothers' attachment security.ResultsThe groups differed significantly in changes in mother–infant interaction, infant mental health problems, and mothers' attachment security.Practice ImplicationsACBA may enhance mother–infant interaction and infants' mental health.
Expansion of acidophytic late‐successional bryophytes in Dutch fens between 1940 and 2000
Authors: Paulissen Maurice P.C.P. , Schaminée Joop H.J. , During Heinjo J. , Wieger Wamelink G.W. , Verhoeven Jos T.A. 
Published: May 2013

AbstractQuestionHow did frequency and local abundance of key bryophytes in Dutch fens change between 1940 and 2000?LocationThe Netherlands.MethodsA total of 1939 vegetation relevés, objectively assigned to the class Parvocaricetea and dating from the period 1940–1999 inclusive, were extracted from a national Netherlands database. From this relevé set, two additional data sets were derived; these were syntaxonomically homogeneous at the association level. One contained 418 Scorpidio‐Caricetum diandrae relevés and the other 956 Pallavicinio‐Sphagnetum relevés. The following analyses were done for these three data sets: frequency and local abundance change of 13 bryophyte species over three 20‐yr periods were described using logistic regression and the nonparametric Jonckheere–Terpstra test, respectively.ResultsAcidophytic, late‐successional species, notably Sphagnum palustre and Polytrichum uliginosum, have replaced relatively early‐successional species such as brown mosses, Sphagnum subnitens and Sphagnum squarrosum during the studied period. The results were mostly consistent across the three data sets. Local abundance patterns generally paralleled those of frequency, although cover trends were often less robust.ConclusionsDrastic changes have taken place in the bryophyte layer of Dutch fens between 1940 and 2000. Our study has shown that acidophytic, late‐successional bryophytes have replaced relatively early‐successional brown moss and Sphagnum species. Both hydrological changes and nutrient shifts (in particular phosphorus enrichment and ammonium toxicity) appear to have been responsible for the observed rapid shifts in the bryophyte layer of Dutch fens.
Serum nitrotyrosine and psychometric tests as indicators of impaired fitness to drive in cirrhotic patients with minimal hepatic encephalopathy
Authors: Felipo Vicente , Urios Amparo , Valero Pedro , Sánchez Mar , Serra Miguel A. , Pareja Ignacio , Rodríguez Felicidad , Gimenez‐Garzó Carla , Sanmartín Jaime , Montoliu Carmina 
Published: May 2013

AbstractBackground & AimsCirrhotic patients with minimal hepatic encephalopathy (MHE) show impaired driving ability and increased vehicle accidents. The neurological deficits contributing to impair driving and the underlying mechanisms are poorly understood. Early detection of driving impairment would help to reduce traffic accidents in MHE patients. It would be therefore useful to have psychometric or biochemical parameters reflecting driving impairment. The aims of this work were as follows: (i) to shed light on the neurological deficits contributing to impair driving; (ii) to assess whether some psychometric test or biochemical parameter is a good indicator of driving impairment.MethodsWe assessed in 22 controls, 36 cirrhotic patients without and 15 with MHE, driving performance using a driving simulator (SIMUVEG) and Driver Test. MHE was diagnosed using the psychometric hepatic encephalopathy score (PHES). Psychometric tests assessing different neurological functions (mental processing speed, attention, visuo‐spatial and bimanual coordination) were performed. Blood ammonia and parameters related with nitric oxide‐cGMP metabolism, IL‐6, IL‐18 and 3‐nitrotyrosine were measured.ResultsPatients with MHE showed impaired driving ability correlating with MHE grade, with impaired vehicle lateral control in spite of reduced driving speed. Patients with MHE show psychomotor slowing, longer reaction times, impaired bimanual and visuo‐spatial coordination and concentrated attention and slowed speed of anticipation and increased blood ammonia, cGMP, IL‐6, IL‐18 and 3‐nitrotyrosine.ConclusionsImpaired mental processing speed, attention and alterations in visuo‐spatial and motor coordination seem main contributors to impaired driving ability in patients with MHE. Increased serum 3‐nitrotyrosine is associated with impaired driving ability.
A pilot study of hepatic arterial infusion of chemotherapy for patients with advanced hepatocellular carcinoma who have failed anti‐angiogenic therapy
Authors: Shao Yu‐Yun , Liang Po‐Chin , Wu Yao‐Ming , Huang Chun‐Chieh , Huang Kai‐Wen , Cheng Jason C. , Hsu Chih‐Hung , Hsu Chiun , Cheng Ann‐Lii , Lin Zhong‐Zhe 
Published: May 2013

AbstractBackground & AimsFor patients with advanced hepatocellular carcinoma (HCC) who have failed first‐line anti‐angiogenic therapy, there is no salvage treatment. Hepatic arterial infusion of chemotherapy (HAIC) has been reported to achieve substantial treatment responses in HCC patients. We aimed to explore the feasibility of using HAIC as second‐line therapy for advanced HCC.MethodsWe retrospectively reviewed all consecutive patients who received HAIC for advanced HCC after failure of first‐line anti‐angiogenic therapy at a single institute. Patients received HAIC with 60 mg/m2 cisplatin on Day 2, and 500 mg/m2/d dose of 5‐fluorouracil on Days 1–3. The treatment was repeated every 21 days and continued until disease progression or the occurrence of intolerable toxicities. Tumour assessment was performed after every 3 cycles of HAIC following RECIST criteria, version 1.0.ResultsA total of 23 patients were included. Eleven (48%) patients had main portal vein thrombosis. Liver reserve was classified as Child‐Pugh A in 19 (83%) patients and B in 4 (17%) patients. No complete response was observed, although 6 (26%) patients showed partial responses. The median progression‐free survival was 4.4 months, and the median overall survival was 7.5 months. Common toxicities included bone marrow suppression, elevated transaminase levels, neutropenia, nausea and malaise. Only 7 (30%) patients experienced grade 3 or 4 toxicities, and no patients withdrew from the therapy because of intolerable or life‐threatening toxicities.ConclusionHAIC is a feasible second‐line therapy for patients with advanced HCC who have failed anti‐angiogenic therapy.
Rise and fall of HCV‐related hepatocellular carcinoma in Italy: a long‐term survey from the ITA.LI.CA centres
Authors: Cazzagon Nora , Trevisani Franco , Maddalo Gemma , Giacomin Anna , Vanin Veronica , Pozzan Caterina , Poggio Paolo Del , Rapaccini Gianludovico , Nolfo Anna M. Di , Benvegnù Luisa , Zoli Marco , Borzio Franco , Giannini Edoardo G. , Caturelli Eugenio , Chiaramonte Maria , Foschi Francesco G. , Cabibbo Giuseppe , Felder Martina , Ciccarese Francesca , Missale Gabriele , Baroni Gianluca Svegliati , Morisco Filomena , Pecorelli Anna , Farinati Fabio ,   for The Italian Liver Cancer (ITA.LI.CA) Group
Published: May 2013

AbstractBackground & AimsHepatitis C virus (HCV) is the leading aetiological factor of HCC in the western world where, overall, its incidence is increasing, despite data suggesting an initial drop in some areas. The aim of this study was to evaluate epidemiology, clinical features and survival of HCV‐related HCC (HCV‐HCC) in a wide time range in Italy.MethodsMulticentre retrospective study including 3695 patients prospectively recruited by the ITA.LI.CA group. Patients were classified into three subgroups according to aetiology (Group A[GA], pure HCV; Group B[GB], HCV + cofactors; and Group C[GC], non‐HCV) and in 5 time cohorts (5 years each), according to the year of diagnosis. Age, gender, Child–Pugh score, modality of diagnosis, stage, presence of thrombosis/metastases, type of treatment and survival were analysed.ResultsA total of 1801 GA patients, 445 GB and 1333 GC were recruited. The number of GA patients peaked in the 1996–2000, gradually dropping thereafter (P < 0.0001), as observed for GB (P < 0.0001). Age at diagnosis increased (P < 0.0001), while percentage of patients diagnosed during surveillance and stage improved only in GA (P = 0.02 and P = 0.003 respectively). The survival significantly increased over time particularly in GA (median 37 months) and was longer in GA than in GB and GC (P < 0.0001).ConclusionsThe prevalence of HCC‐HCV is decreasing in Italy since 2001. HCV‐HCC patients are older, more frequently diagnosed under surveillance and in an earlier stage. HCC survival improved in the last 15 years and is significantly higher in patients with HCV‐HCC. We therefore expect a further drop in both incidence and mortality for HCV‐HCC in the years to come.
Ethnicity and children's diets: the practices and perceptions of mothers in two minority ethnic groups in Denmark
Authors: Nielsen Annemette , Krasnik Allan , Holm Lotte 
Published: May 2013

AbstractThis study explores concerns and dilemmas connected with diet, health and child‐feeding in families with ethnic minority background. The aim is to contribute to better targeting of dietary advice to ethnic minority parents in Denmark. Four focus group interviews were carried out with mothers of children between 4 months and 2 and a half years who were descendants of Turkish or Pakistani immigrants. The focus groups investigated: (1) everyday feeding practices; (2) values and concerns behind food choice; (3) social and cultural norms influencing feeding and eating practices; (4) experienced dilemmas in dietary change; and (5) sources of nutritional advice. Public health authorities in Denmark tend to link diet‐related health problems among ethnic minority populations with their ethnic identity, dichotomising ethnic and Danish dietary habits. This may overlook values and concerns other than those related to ethnicity that are sometimes more important in determining food habits. The present study found that child‐feeding practices were shaped by two main aims: (1) securing and improving child health; and (2) ensuring multi‐cultural eating competence in children. The results confirm that ethnic distinctions do matter in the concerns and dilemmas mothers experience when feeding their children, but they also challenge the health authorities' reliance on dichotomies in promoting health among immigrant families. The participants' ethnic self‐identification through food practices did not refer primarily to the birthplaces of their parents. Rather, it was context dependent and directed simultaneously towards majority and minority culture.
Implementation of geriatric acute care best practices: Initial results of the NICHE SITE self‐evaluation
Authors: Boltz Marie , Capezuti Elizabeth , Shuluk Joseph , Brouwer Julianna , Carolan Deirdre , Conway Shirley , DeRosa Sue , LaReau Rita , Lyons Denise , Nickoley Sue , Smith Tyleen , Galvin James E. 
Published: May 2013

AbstractNurses Improving Care of Healthsystem Elders (NICHE) provides hospitals with tools and resources to implement an initiative to improve health outcomes in older adults and their families. Beginning in 2011, members have engaged in a process of program self‐evaluation, designed to evaluate internal progress toward developing, sustaining, and disseminating NICHE. This manuscript describes the NICHE Site Self‐evaluation and reports the inaugural self‐evaluation data in 180 North American hospitals. NICHE members evaluate their program utilizing the following dimensions of a geriatric acute care program: guiding principles, organizational structures, leadership, geriatric staff competence, interdisciplinary resources and processes, patient‐ and family‐centered approaches, environment of care, and quality metrics. The majority of NICHE sites were at the progressive implementation level (n = 100, 55.6%), having implemented interdisciplinary geriatric education and the geriatric resource nurse (GRN) model on at least one unit; 29% have implemented the GRN model on multiple units, including specialty areas. Bed size, teaching status, and Magnet status were not associated with level of implementation, suggesting that NICHE implementation can be successful in a variety of settings and communities.
From Experience to Metaphysics: On Experience‐based Intuitions and their Role in Metaphysics
Authors: Benovsky* Jiri 
Published: May 2013

AbstractMetaphysical theories are often counter‐intuitive. But they also often are strongly supported and motivated by intuitions. One way or another, the link between intuitions and metaphysics is a strong and important one, and there is hardly any metaphysical discussion where intuitions do not play a crucial role. In this article, I will be interested in a particular kind of such intuitions, namely those that come, at least partly, from experience. There seems to be a route from experience to metaphysics, and this is the core of my interest here. In order to better understand such ‘arguments from experience’ and the kind of relationship there is between this type of intuitions and metaphysical theories, I shall examine four particular cases where a kind of experience‐based intuition seems to motivate or support a metaphysical theory. At the end of the day, I shall argue that this route is a treacherous one, and that in all of the four cases I shall concentrate on, phenomenological considerations are in fact orthogonal to the allegedly ‘corresponding’ metaphysical claims. An anti‐realist view of metaphysics will emerge.
Transgenerational effects of plant sex and arbuscular mycorrhizal symbiosis
Authors: Varga Sandra , Vega‐Frutis Rocío , Kytöviita Minna‐Maarit 
Published: May 2013

Summary

In gynodioecious plants, females are predicted to produce more and/or better offspring than hermaphrodites in order to be maintained in the same population. In the field, the roots of both sexes are usually colonized by arbuscular mycorrhizal (AM) fungi. Transgenerational effects of mycorrhizal symbiosis are largely unknown, although theoretically expected.

We examined the maternal and paternal effects of AM fungal symbiosis and host sex on seed production and posterior seedling performance in Geranium sylvaticum, a gynodioecious plant. We hand‐pollinated cloned females and hermaphrodites in symbiosis with AM fungi or in nonmycorrhizal conditions and measured seed number and mass, and seedling survival and growth in a glasshouse experiment.

Females produced more seeds than hermaphrodites, but the seeds did not germinate, survive or grow better. Mycorrhizal plants were larger, but did not produce more seeds than nonmycorrhizal plants. Transgenerational parental effects of AM fungi were verified in seedling performance.

This is the first study to show transgenerational mycorrhiza‐mediated parental effects in a gynodioecious species. Mycorrhizal symbiosis affects plant fitness mainly through female functions with enduring effects on the next generation.
Cotton plasma membrane intrinsic protein 2s (PIP2s) selectively interact to regulate their water channel activities and are required for fibre development
Authors: Li Deng‐Di , Ruan Xiang‐Mei , Zhang Jie , Wu Ya‐Jie , Wang Xiu‐Lan , Li Xue‐Bao 
Published: May 2013

Summary

Aquaporins are thought to be associated with water transport and play important roles in cotton (Gossypium hirsutum) fibre elongation. Among aquaporins, plasma membrane intrinsic proteins (PIPs) constitute a plasma‐membrane‐specific subfamily and are further subdivided into PIP1 and PIP2 groups.

In this study, four fibre‐preferential GhPIP2 genes were functionally characterized. The selective interactions among GhPIP2s and their interaction proteins were studied in detail to elucidate the molecular mechanism of cotton fibre development.

GhPIP2;3 interacted with GhPIP2;4 and GhPIP2;6, but GhPIP2;6 did not interact with GhPIP2;4. Coexpression of GhPIP2;3/2;4 or GhPIP2;3/2;6 resulted in a positive cooperative effect which increased the permeability coefficient of oocytes, while GhPIP2;4/2;6 did not. GhBCP2 (a blue copper‐binding protein) inhibited GhPIP2;6 water channel activity through their interaction. Overexpression of GhPIP2 genes in yeast induced longitudinal growth of the host cells. By contrast, knockdown of expression of GhPIP2 genes in cotton by RNA interference markedly hindered fibre elongation.

In conclusion, GhPIP2 proteins are the primary aquaporin isoforms in fibres. They selectively form hetero‐oligomers in order to regulate their activities to meet the requirements for rapid fibre elongation.
Early maxillary surgical ciliated cyst after Le Fort I untreated for 20 years
Authors: Moe J.S. , Magliocca K.R. , Steed M.B. 
Published: May 2013

AbstractThe surgical ciliated cyst of the maxilla (SCCM) is a rare, delayed complication of surgical intervention in the maxilla sinus. It can present several years following surgery, and has been postulated to arise from implantation of the respiratory epithelium during the surgical procedure. In this article, we report the case of a patient with SCCM who presented 20 years following Le Fort I surgery. Previous radiographs showed evidence of a right maxillary cystic lesion as early as 2 years following surgery. We describe the clinical, radiographic and histolopathologic presentation of the entity as well as the surgical management. This case demonstrates maxillary surgical ciliated cyst development with a relatively short latency period and underscores the paucity in understanding of the aetiology, pathophysiology and growth kinetics of this lesion.
Surgical ciliated cyst of the maxilla after maxillary sinus surgery: a case report
Authors: Fernandes K.S. , Gallottini M.H.C. , Felix V.B. , Santos P.S.S. , Nunes F.D. 
Published: May 2013

AbstractThe surgical ciliated cyst of the maxilla is a rare lesion and appears as a delayed complication after surgery in the maxillary sinus, midface osteotomies, traumatic tooth extraction and maxillary fractures. This lesion has a high incidence in Japan and is detected in up to 20% of patients who have undergone a radical operation on the maxillary sinus, but it is quite rare in Western countries. We report a case that occurred 15 years after a maxillary sinus surgery in a Caucasian man. A well‐defined unilocular radiolucency in the right posterior maxilla was noted radiographically. The lesion was completely excised, and upon histological examination, findings were consistent with surgical ciliated cyst. This lesion may present histologically different epithelial linings, but respiratory epithelium was the most frequent. Enucleation is the treatment of choice.
Does C1 Fracture Displacement Correlate with Transverse Ligament Integrity?
Authors: Radcliff Kristen E , Sonagli Marcos A , Rodrigues Luciano M , Sidhu Gursukhman S , Albert Todd J , Vaccaro Alexander R 
Published: May 2013

ObjectiveThe Rule of Spence states that displacement of the C1 lateral masses by >6.9–8.1 mm suggests loss of transverse ligament integrity. The purpose of this study was to establish the thresholds of C1 displacement on CT scans that correspond to transverse ligament disruption.MethodsOver four years, consecutive patients with acute C1 fractures with at least three fracture lines were analyzed. CT measurements and MRI were assessed by blinded observers for bony displacement in the axial (internal and external lateral mass separation), coronal and sagittal planes and transverse ligament integrity.ResultsEighteen patients were studied. Mean CT bony measurements were as follows: internal border lateral mass separation (ILM) 23.3 ± 3.4 mm, external border lateral mass separation (ELM) 50.3 ± 4.3 mm, total C1 lateral mass overhang over the C2 superior process (LMO) 5.4 ± 1.3 mm. Twelve patients were identified as having intact transverse ligament and six had transverse ligament disruption. There was no difference in mean normalized ILM, ELM, or LMO between patients with or without transverse ligament integrity (P > 0.05).ConclusionThere was no correlation between bony displacement and transverse ligament integrity. CT scans post‐injury may not show the position of maximal displacement. If there is clinical concern about a possible transverse ligament injury, MRI should be performed.