bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure and Properties of Madden–Julian Oscillations Deduced from DYNAMO Sounding Arrays
Authors: Johnson Richard H. , Ciesielski Paul E. 
Published: June 2013

Abstract
The kinematic and thermodynamic characteristics of the October and November 2011 Madden–Julian oscillations (MJOs) that occurred over the Indian Ocean during Dynamics of the MJO (DYNAMO) are investigated. Analyses are presented 1) for two primary sounding arrays, where results are independent of model parameterizations, and 2) on larger scales, including the Indian Ocean, using operational and reanalysis data.
Mean precipitation during DYNAMO was characterized by maxima in two east–west bands north and south of the equator. This pattern alternated between two bands during the inactive phase of the MJOs and a single rainfall maximum on the equator during the active phases. Precipitation over the northern sounding array (NSA), where the MJO signal was strongest, was significantly modulated by the MJOs, while the southern array experienced more frequent, briefer episodes of rainfall mostly related to ITCZ convection. Over the NSA the MJOs were characterized by gradual moistening of the low to midtroposphere over approximately 2-week periods. The October MJO featured multiple westward-moving, 2-day disturbances whereas the November MJO principally comprised two prominent Kelvin waves. Patterns of moistening, divergence, and vertical motion suggest a stepwise progression of convection, from shallow cumulus to congestus to deep convection. Tilted thermal anomalies in the upper troposphere–lower stratosphere reveal gravity or Kelvin waves excited by the MJO convective envelopes, which modulate the tropopause and contribute to preactive-phase upper-tropospheric moistening. While there is a number of similarities in the characteristics of the two MJOs, there are sufficient differences to warrant caution in generalizing results from these two events.
A Twenty-First-Century California Observing Network for Monitoring Extreme Weather Events
Authors: White A. B. , Anderson M. L. , Dettinger M. D. , Ralph F. M. , Hinojosa A. , Cayan D. R. , Hartman R. K. , Reynolds D. W. , Johnson L. E. , Schneider T. L. , Cifelli R. , Toth Z. , Gutman S. I. , King C. W. , Gehrke F. , Johnston P. E. , Walls C. , Mann D. , Gottas D. J. , Coleman T. 
Published: June 2013

Abstract
During Northern Hemisphere winters, the West Coast of North America is battered by extratropical storms. The impact of these storms is of paramount concern to California, where aging water supply and flood protection infrastructures are challenged by increased standards for urban flood protection, an unusually variable weather regime, and projections of climate change. Additionally, there are inherent conflicts between releasing water to provide flood protection and storing water to meet requirements for the water supply, water quality, hydropower generation, water temperature and flow for at-risk species, and recreation. To improve reservoir management and meet the increasing demands on water, improved forecasts of precipitation, especially during extreme events, are required. Here, the authors describe how California is addressing their most important and costliest environmental issue—water management—in part, by installing a state-of-the-art observing system to better track the area’s most severe wintertime storms.
Enhanced Radar Backscattering due to Oriented Ice Particles at 95 GHz during StormVEx
Authors: Marchand Roger , Mace Gerald G. , Hallar A. Gannet , McCubbin Ian B. , Matrosov Sergey Y. , Shupe Matthew D. 
Published: June 2013

Abstract
Nonspherical atmospheric ice particles can enhance radar backscattering and attenuation above that expected from spheres of the same mass. An analysis of scanning 95-GHz radar data collected during the Storm Peak Laboratory Cloud Property Validation Experiment (StormVEx) shows that at a least a small amount of enhanced backscattering was present in most radar scans, with a median enhancement of 2.4 dB at zenith. This enhancement will cause an error (bias) in ice water content (IWC) retrievals that neglect particle orientation, with a value of 2.4 dB being roughly equivalent to a relative error in IWC of 43%. Of the radar scans examined, 25% had a zenith-enhanced backscattering exceeding 3.5 dB (equivalent to a relative error in IWC in excess of 67%) and 10% of the scans had a zenith-enhanced backscattering exceeding 6.4 dB (equivalent to a relative error in IWC in excess of 150%). Cloud particle images indicate that large enhancement typically occurred when planar crystals (e.g., plates and dendrites) were present, with the largest enhancement occurring when large planar crystals were falling out of a supercooled liquid-water layer. More modest enhancement was sometimes due to planar crystals, but it was also sometimes likely a result of horizontally oriented nonspherical irregularly shaped particles. The analysis also shows there is a strong correlation (about −0.79) between the change in slant 45° depolarization ratio with radar scan elevation angle and the magnitude of the zenith-enhanced backscattering, suggesting that measurements of the slant depolarization ratio can be used to improve radar-based cloud microphysical property retrievals.
Prevention of common mental disorders: What can we learn from those who have gone before and where do we go next?
Authors: Jacka Felice N , Reavley Nicola J , Jorm Anthony F , Toumbourou John W , Lewis Andrew J , Berk Michael 
Published: June 2013

Objective Prevention strategies have made a major contribution to the considerable successes in reductions in cardiovascular disease and cancer mortality seen in recent decades. However, in the field of psychiatry, similar population-level initiatives in the prevention of common mental disorders, depression and anxiety, are noticeably lacking. This paper aims to provide a brief overview of the existing literature on the topic of the prevention of common mental disorders and a commentary regarding the way forward for prevention research and implementation. Methods This commentary considers what we currently know, what we might learn from the successes and failures of those working in prevention of other high prevalence health conditions, and where we might go from here. Taking cognisance of previous preventive models, this commentary additionally explores new opportunities for preventive approaches to the common mental disorders. Results The consensus from a large body of evidence supports the contention that interventions to prevent mental disorders across the lifespan can be both effective and cost-effective. However, funding for research in the area of prevention of common mental disorders is considerably lower than that for research in the areas of treatment, epidemiology and neurobiology. Thus, there is a clear imperative to direct funding towards prevention research to redress this imbalance. Future prevention interventions need to be methodologically rigorous, scalable to the population level and include economic evaluation. Evidence-based knowledge translation strategies should be developed to ensure that all stakeholders recognise preventing mental disorders as an imperative, with appropriate resources directed to this objective. Conclusion There has been a recent expansion of research into potentially modifiable risk factors for depression, and it is now timely to make a concerted effort to advance the field of prevention of common mental disorders.
Factors influencing participation in cardiac rehabilitation programmes after referral and initial attendance: qualitative systematic review and meta-synthesis
Authors: Clark Alexander M , King-Shier Kathryn M , Spaling Melisa A , Duncan Amanda S , Stone James A , Jaglal Susan B , Thompson David R , Angus Jan E 
Published: June 2013

Background: Greater participation in cardiac rehabilitation improves morbidity and mortality in people with coronary heart disease, but little is understood of patients’ decisions to participate. Methods: To develop interventions aimed at increasing completion of programmes, we conducted a qualitative systematic review and meta-synthesis to explore the complex factors and processes influencing participation in cardiac rehabilitation programmes after referral and initial access. To be included in the review, studies had to contain a qualitative research component, population specific data on programme participation in adults >18 years, and be published ≥1995 as full articles or theses. Ten databases were searched (31 October 2011) using 100+ search terms. Results: Of 2264 citations identified, 62 studies were included involving: 1646 patients (57% female; mean age 64.2), 143 caregivers, and 79 professionals. Patients’ participation was most strongly influenced by perceptions of the nature, suitability and scheduling of programmes, social comparisons made possible by programmes, and the degree to which programmes, providers, and programme users met expectations. Women’s experiences of these factors rendered them less likely to complete. Comparatively, perceptions of programme benefits had little influence on participation. Conclusions: Factors reducing participation in programmes are varied but amenable to intervention. Participation should be viewed as a ‘consumer behaviour’ and interventions should mobilize family support, promote ‘patient friendly’ scheduling, and actively harness the social, identity-related, and experiential aspects of participation.
Does altering inclination alter effectiveness of treadmill training for gait impairment after stroke? A randomized controlled trial
Authors: Carda Stefano , Invernizzi Marco , Baricich Alessio , Cognolato Gianluca , Cisari Carlo 
Published: June 2013

Objective: To assess whether a downhill walking training programme is more effective than the same amount of training applied uphill in chronic stroke survivors. Design: Randomized, single-blind study. Setting: Outpatient rehabilitation service. Methods: Thirty-eight adults with hemiplegia from stroke lasting more than three months were randomly allocated to one of the two groups: ‘UP’ – 45 minutes of physical therapy + 30 minutes of treadmill with 5% ascending slope; and ‘DOWN’ – 45 minutes of physical therapy + 30 minutes of treadmill with 5% descending slope. Both groups were treated 5 times a week for six weeks. Patients were evaluated before treatment, at the end of treatment and after three months. Outcome measures: Primary outcome measure was the number of patients showing an improvement in 6-minute walking test (6MWT) greater than 50 m. Secondary outcome measures were: (1) number of patients showing a clinically relevant improvement of gait speed during 10-m walking test (10mWT); (2) number of patients showing an improvement in timed up and go (TUG) greater than minimal detectable change. Results: Both groups had a significant improvement after treatment and at follow-up. At the end of treatment, compared to UP group, more patients in the DOWN group showed clinically significant improvements in primary and secondary outcomes (16/19 patients for 6MWT, 11/19 patients for 10mWT and 9/19 patients for TUG compared with 3/19, 4/19 and 2/19 patients, respectively, P < 0.01). At follow-up, results were similar except for 10mWT. Conclusions: In chronic stroke patients, downhill treadmill training produces a bigger effect than uphill training.
Impact of Pharmacy Student and Resident-Led Discharge Counseling on Heart Failure Patients
Authors: Szkiladz Andrew , Carey Katherine , Ackerbauer Kimberly , Heelon Mark , Friderici Jennifer , Kopcza Kathleen 
Published: June 2013

Purpose: Many health systems have implemented interventions to reduce the rate of heart failure readmissions. Pharmacists have the training and expertise to provide effective medication-related education. However, few studies have examined the impact of discharge education provided by pharmacy students and residents on patients hospitalized with heart failure exacerbations. Methods: This was a nonrandomized intervention study evaluating the impact of a pharmacy student and resident-led discharge counseling program on heart failure readmissions. The primary end point was the 30-day heart failure readmission rate. Secondary end points included self-reported patient understanding of medications, number of medication errors documented, and estimated associated cost avoidance. Results: A total of 86 and 94 patients were enrolled into the intervention and control groups, respectively. No statistically significant difference in readmission rates was detected between the intervention and the control groups. Thirty-four medication errors and discrepancies were documented, or 1 for every 2.5 patients counseled, resulting in an estimated cost avoidance of $4241 for the institution. Eighty-nine percent of patients who received discharge counseling agreed they had a better understanding of their medications after speaking with a pharmacy resident or student. Conclusions: There was no statistically significant difference in readmission rates; however, several medication errors were prevented, and a large percentage of patients expressed an improved understanding of their medications.
Lymphogranuloma venereum detected from the pharynx in four London men who have sex with men
Authors: Dosekun O , Edmonds S , Stockwell S , French P , White JA 
Published: June 2013

Summary Lymphogranuloma venereum (LGV) is an established cause of proctitis in men who have sex with men (MSM). Currently in the UK, testing for pharyngeal Chlamydia trachomatis (CT) is not routine, and LGV typing is usually only performed in patients with anorectal symptoms. We report four cases where LGV-associated CT DNA was detected from the pharynx in MSM, demonstrating that nucleic acid amplification testing (NAAT) can be used for detecting and typing pharyngeal CT infection. These cases also highlight other possible routes of infection for LGV, and add to the broad spectrum of clinical presentations associated with this infection.
Liver function test abnormalities in Nigerian patients with human immunodeficiency virus and hepatitis B virus co-infection
Authors: Iroezindu M O , Agbaji O O , Daniyam C A , Isiguzo G C , Isichei C , Akanbi M O 
Published: June 2013

Summary Data on baseline hepatic function of HIV and hepatitis B virus (HBV) co-infected patients are limited in sub-Saharan Africa. We assessed liver function test (LFT) abnormalities in Nigerian patients with HIV/HBV co-infection to highlight the impact of HIV on HBV-related liver disease in sub-Saharan Africa. A cross-sectional study involving 100 HIV/HBV co-infected patients and 100 age- and sex-matched HBV mono-infected controls. Blood testing for HIV antibodies, CD4+ cell count, hepatitis B surface antigen (HBsAg), hepatitis B e antigen (HBeAg), LFTs, platelet count, fasting blood glucose and lipid profile were carried out. Non-invasive hepatic fibrosis scores (aspartate aminotransferase-platelet ratio index [APRI] and FIB-4) were also calculated. Co-infected patients had deranged liver enzymes more than the controls (77% versus 64%, P = 0.04). The predominant patterns of enzyme derangement in co-infected patients were either predominantly ↑ALP (30% versus 4%, P < 0.0001) or mixed (30% versus 15%, P = 0.01) but predominantly ↑AST/ALT in the controls (25% versus 9%, P = 0.003). Co-infected patients had higher fibrosis scores for both APRI ( P = 0.002) and FIB-4 ( P = 0.0001). On further analysis, LFT abnormalities and fibrosis scores were only significantly higher in co-infected patients in the immune clearance and HBeAg-negative chronic hepatitis phases. LFT abnormalities are common in Nigerians with HBV infection and co-infection with HIV negatively impacts on hepatic function.
Platelet-Rich Plasma in Addition to Rehabilitation for Acute Hamstring Injuries in NFL Players
Authors: Rettig Arthur C. , Meyer Susan , Bhadra Arup K. 
Published: June 2013

Background: Platelet-rich plasma (PRP) injections have been proposed to hasten soft tissue healing. There is a lack of evidence in the current literature to support their efficacy in elite athletes. Purpose: To investigate the effects of the addition of PRP to rehabilitation in the treatment of acute hamstring injuries in professional National Football League (NFL) players and to report the time to return to play. Study Design: Case control study. Methods: Ten NFL players with similar hamstring injury patterns were retrospectively divided into 2 groups. The treatment group (PRP; n = 5) was injected with PRP and the control group (non-PRP; n = 5) was not injected; both groups completed a rehabilitation program. The PRP injections were administered under ultrasound guidance with precise localization of the injury site, within 24 to 48 hours of injury. Age, muscle involved, extent of injury, grading, and time to return to play were noted. Descriptive statistics and the exact Wilcoxon rank-sum test were used for data analysis. Results: The mean age was 23 years (range, 22-27 years) for the PRP group and 26 years (range, 22-28 years) for the non-PRP group ( P = .42). The median longitudinal extent of the injury was 14 cm (range, 9-18 cm) in the PRP group and 15 cm (range, 9-16 cm) in the non-PRP group ( P = .77). The average transverse extent of the injury in the PRP and non-PRP groups was 4 cm (range, 1.6-6 cm) and 3.5 cm (range, 2-5 cm), respectively, and the respective average anteroposterior extent was 4 cm (range, 1.9-5 cm) and 2.9 cm (range, 1.5-4 cm). The long head of biceps femoris was most commonly involved (4 in each group), with a single tear of the semimembranosus in each group. The median injury classification was grade 2 in both groups. The median time to return to play was 20 days (range,16-30 days) in the PRP group and 17 days (range, 8-81 days) in the non-PRP group ( P = .73). Conclusion: There were no significant differences in recovery from hamstring injury between treatment with PRP and routine rehabilitation. A larger, randomized controlled trial is warranted.
CC chemokine receptor 8 potentiates donor Treg survival and is critical for the prevention of murine graft-versus-host disease
Authors: Coghill James M. , Fowler Kenneth A. , West Michelle L. , Fulton LeShara M. , van Deventer Hendrik , McKinnon Karen P. , Vincent Benjamin G. , Lin Kaifeng , Panoskaltsis-Mortari Angela , Cook Donald N. , Blazar Bruce R. , Serody Jonathan S. 
Published: June 2013

Key PointsExtended donor Treg survival is required for protection from GVHD; donor Treg longevity depends on Treg CCR8 expression. Donor CD11c+ APCs promote Treg longevity in vivo; host CD11c+ APCs do not appear to contribute to donor Treg reconstitution.
Advanced drug delivery systems for antithrombotic agents
Authors: Greineder Colin F. , Howard Melissa D. , Carnemolla Ronald , Cines Douglas B. , Muzykantov Vladimir R. 
Published: June 2013

AbstractDespite continued achievements in antithrombotic pharmacotherapy, difficulties remain in managing patients at high risk for both thrombosis and hemorrhage. Utility of antithrombotic agents (ATAs) in these settings is restricted by inadequate pharmacokinetics and narrow therapeutic indices. Use of advanced drug delivery systems (ADDSs) may help to circumvent these problems. Various nanocarriers, affinity ligands, and polymer coatings provide ADDSs that have the potential to help optimize ATA pharmacokinetics, target drug delivery to sites of thrombosis, and sense pathologic changes in the vascular microenvironment, such as altered hemodynamic forces, expression of inflammatory markers, and structural differences between mature hemostatic and growing pathological clots. Delivery of ATAs using biomimetic synthetic carriers, host blood cells, and recombinant fusion proteins that are activated preferentially at sites of thrombus development has shown promising outcomes in preclinical models. Further development and translation of ADDSs that spare hemostatic fibrin clots hold promise for extending the utility of ATAs in the management of acute thrombotic disorders through rapid, transient, and targeted thromboprophylaxis. If the potential benefit of this technology is to be realized, a systematic and concerted effort is required to develop clinical trials and translate the use of ADDSs to the clinical arena.
Lenalidomide induces long-lasting responses in elderly patients with chronic lymphocytic leukemia
Authors: Strati Paolo , Keating Michael J. , Wierda William G. , Badoux Xavier C. , Calin Steliana , Reuben James M. , O’Brien Susan , Kornblau Steven M. , Kantarjian Hagop M. , Gao Hui , Ferrajoli Alessandra 
Published: June 2013

Key Points
Treatment with lenalidomide induces long-lasting responses. Lenalidomide can produce a sustained increase in immunoglobulin levels and a sustained normalization in circulating T cells.
Automatic workflow for the classification of local DNA conformations
Authors: Čech Petr , Kukal Jaromír , Černý Jiří , Schneider Bohdan , Svozil Daniel 
Published: June 2013

Abstract

Background
A growing number of crystal and NMR structures reveals a considerable structural polymorphism of DNA architecture going well beyond the usual image of a double helical molecule. DNA is highly variable with dinucleotide steps exhibiting a substantial flexibility in a sequence-dependent manner. An analysis of the conformational space of the DNA backbone and the enhancement of our understanding of the conformational dependencies in DNA are therefore important for full comprehension of DNA structural polymorphism.

Results
A detailed classification of local DNA conformations based on the technique of Fourier averaging was published in our previous work. However, this procedure requires a considerable amount of manual work. To overcome this limitation we developed an automatic classification method consisting of the combination of supervised and unsupervised approaches. A proposed workflow is composed of k-NN method followed by a non-hierarchical single-pass clustering algorithm. We applied this workflow to analyze 816 X-ray and 664 NMR DNA structures released till February 2013. We identified and annotated six new conformers, and we assigned four of these conformers to two structurally important DNA families: guanine quadruplexes and Holliday (four-way) junctions. We also compared populations of the assigned conformers in the dataset of X-ray and NMR structures.

Conclusions
In the present work we developed a machine learning workflow for the automatic classification of dinucleotide conformations. Dinucleotides with unassigned conformations can be either classified into one of already known 24 classes or they can be flagged as unclassifiable. The proposed machine learning workflow permits identification of new classes among so far unclassifiable data, and we identified and annotated six new conformations in the X-ray structures released since our previous analysis. The results illustrate the utility of machine learning approaches in the classification of local DNA conformations.