bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Phase II Trial of Ridaforolimus in Advanced Endometrial Carcinoma
Authors: Oza Amit M. , Pignata Sandro , Poveda Andres , McCormack Mary , Clamp Andrew , Schwartz Benjamin , Cheng Jonathan , Li Xiaoyun , Campbell Kristy , Dodion Pierre , Haluska Frank G. 
Published: June 2015

Purpose The prognosis for women with recurrent and metastatic endometrial cancer is poor, and improved therapies are needed. The mammalian target of rapamycin (mTOR) pathway is an important target, and mTOR inhibitors show clinical activity in endometrial cancer. Patients and Methods An open-label, multicenter, randomized, phase II trial of oral ridaforolimus compared with progestin or investigator choice chemotherapy (comparator) was undertaken in women with metastatic or recurrent endometrial cancer who had progressive disease following one or two lines of chemotherapy and no hormonal therapy. The primary end point was progression-free survival (PFS) assessed by independent radiologic review. Results One hundred thirty patients were enrolled (64 received ridaforolimus and 66 received the comparator), and median age was 66 years. Treatment discontinuation as a result of adverse events was 33% with ridaforolimus versus 6% with the comparator, with common (> 10%) grade 3 toxicities being hyperglycemia, anemia, and diarrhea. Thirty-eight percent (ridaforolimus) versus 71% (comparator) of patients discontinued treatment as a result of disease progression. Median PFS at the protocol prespecified interim analysis with 58 PFS events (primary end point) was 3.6 months (95% CI, 2.7 to 7.3 months) for ridaforolimus and 1.9 months (95% CI, 1.9 to 2.3 months) for the comparator (hazard ratio, 0.53; 95% CI, 0.31 to 0.90; P = .008). PFS rate for ridaforolimus versus comparator was 48% versus 18% at 16 weeks and 38% versus 15% at 24 weeks. Objective response rate for ridaforolimus versus comparator was 0% versus 4% (P = .925), and stable disease was achieved in 35% versus 17% of patients (P = .021). Conclusion Oral ridaforolimus shows encouraging activity in advanced endometrial cancer but is associated with significant toxicity. Inhibition of the PI3K/Akt/mTOR pathway may be a viable therapeutic target.
Presence and Number of Lymph Node Metastases Are Associated With Compromised Survival for Patients Younger Than Age 45 Years With Papillary Thyroid Cancer
Authors: Adam Mohamed Abdelgadir , Pura John , Goffredo Paolo , Dinan Michaela A. , Reed Shelby D. , Scheri Randall P. , Hyslop Terry , Roman Sanziana A. , Sosa Julie A. 
Published: June 2015

Purpose Cervical lymph node metastases are recognized as a prognostic indicator only in patients age 45 years or older with papillary thyroid cancer (PTC); patients younger than age 45 years are perceived to have low-risk disease. The current American Joint Committee on Cancer staging for PTC in patients younger than age 45 years does not include cervical lymph node metastases. Our objective was to test the hypothesis that the presence and number of cervical lymph node metastases have an adverse impact on overall survival (OS) in patients younger than age 45 years with PTC. Patients and Methods Adult patients younger than age 45 years undergoing surgery for stage I PTC (no distant metastases) were identified from the National Cancer Data Base (NCDB; 1998-2006) and from SEER 1988-2006 data. Multivariable models were used to examine the association of OS with the presence of lymph node metastases and number of metastatic nodes. Results In all, 47,902 patients in NCDB (11,740 with and 36,162 without nodal metastases) and 21,855 in the SEER database (5,188 with and 16,667 without nodal metastases) were included. After adjustment, OS was compromised for patients with nodal metastases compared with patients who did not have them (NCDB: hazard ratio (HR), 1.32; 95% CI, 1.04 to 1.67; P = .021; SEER: HR, 1.29; 95% CI, 1.08 to 1.56; P = .006). After adjustment, increasing number of metastatic lymph nodes was associated with decreasing OS up to six metastatic nodes (HR, 1.12; 95% CI, 1.01 to 1.25; P = .03), after which more positive nodes conferred no additional mortality risk (HR, 0.99; 95% CI, 0.99 to 1.05; P = .75). Conclusion Our results suggest that cervical lymph node metastases are associated with compromised survival in young patients, warranting consideration of revised American Joint Committee on Cancer staging. A change point of six or fewer metastatic lymph nodes seems to carry prognostic significance, thus advocating for rigorous preoperative screening for nodal metastases.
The Religious Other in the Histories of Gregory of Tours
Authors: Choda Kamil 
Published: June 2015

The Religious Other in the Histories of Gregory of Tours
The question of the religious other is discussed from the perspective Gregory of Tours himself would have identified with: namely, that of eternal salvation (a necessary prerequisite for which is embracing the Catholic doctrine) or condemnation Arians, Jews and Catholics lapsed into heresy shall eventually face. Gregory’s portrayal of the followers of Arius (who, according to him, not only cannot be called Christians, but follow in footsteps of pagan Roman persecutors of Christianity) is discussed; the futility of theological debate as a mean to influence those non‑Trinitarians is showed and the miraculous is stressed as the only effective tool of gaining them for the Church. Secondly, the question of Jews in Gregory’s narrative: their loss of the chosen people status, their inability to read the Old Testament Christologically and their not partaking in the miraculous that proved so decisive for the conversion of Arians is stressed; the political pressure of secular and ecclesiastical authorities is presented as the only, albeit ineffective, way of integrating members of the Jewish community into the Church. Finally, the learned heresies produced by the Church elite, that can be effectively addressed by employing the theological discourse and hierarchical admonition, are contrasted with the unrest caused among common people by popular prophets challenging the Church authority and her monopoly on the miraculous.
The Sinful Woman as an Example of Metanoia in the Byzantian Poetry
Authors: Heszen Agnieszka 
Published: June 2015

Sinful Woman as an Example of Metanoia in the Byzantian Poetry
A story about the sinful woman is told in the Gospel, where she is an example of deep repentance. The Byzantine authors often used this example in their poetic and homiletic works. In this article I juxtapose three genres of Byzantine poetry and I compare the literary motif of the sinful woman which appears in each of them. I choose the most representative genres of Byzantine poetry, as kontakion, kanon and troparion (or sticheron). In the first part I examine Romanos’ kontakion On the sinful woman, in the second one – Andrew of Crete’s the Megas Kanon and in the last part – Kassia’s troparion, commonly called On Mary Magdalene. The works are connected by the common theme, but they are different in respect of the form and the literary genre. In my paper I try to show how the same example of the Gospel parable is used in different ways in literary works.
Penalties in Action in Classical Athens
Authors: Kucharski Jan 
Published: June 2015

Penalties in Action in Classical Athens. A Preliminary Survey
This paper attempts to look at the inner workings of the punitive system in ancient Athens. After a brief survey of the range of penalties available in Classical Athens (capital punishment, exile and outlawry, disenfranchisement, financial penalties, imprisonment, corporal penalties), it proceeds first to examine their nature (as they frequently fail to meet our criteria of punishment), and then to map them on the substance vs. procedure controversy regarding the Athenian legal system. The last two sections of the paper are devoted to the manner in which penalties were imposed (summary punishment, punishment by sentence, “automatic” punishment) and executed (private vs. public execution of court verdicts; coercive measures etc.).
The Greek Voice Aspirates and Balkan Indo-European
Authors: Piwowarczyk Dariusz R. 
Published: June 2015

Greek Voice Aspirates and Balkan Indo-European
In contemporary Indo‑European linguistics growing attention is given to the issue of the “Balkan Indo‑European” subgrouping of the Indo‑European languages. Different treatment of the Proto‑Indo‑European voiced aspirates in Greek and the Balkan languages presents a difficulty for this specific classification, as both Greek and the Indo‑European languages of the Balkans are members of the subgroup. The problem might be overcome by assuming a longer period of the retention of voiced aspirates in the Balkan region than originally thought of, accounting for inconsistencies in Linear B writing, the medium of the earliest variety of Greek – Mycenaean.
Classical Culture and European Identity: Pagan Antiquity in the Writings of Pope Benedict XVI
Authors: Stróżyński Mateusz 
Published: June 2015

Classical Culture and European Identity: Pagan Antiquity in the Writings of Pope Benedict XVI
The paper analyses the attitude of Joseph Ratzinger, pope Benedict XVI, towards classical culture and tradition. A careful analysis of the pope’s writings makes it obvious that he addresses Europe’s classical heritage with respect and deep understanding. A number of case studies analysed in the paper allows the reader to see a variety of perspectives on classical antiquity, present in the writings of Benedict XVI.
Claudianus Mamertus in the eyes of Sidonius Apollinaris
Authors: Styka Jerzy 
Published: June 2015

Claudianus Mamertus in the eyes of Sidonius Apollinaris
The present paper discusses the person and literary achievements of Claudianus Mamertus as seen by his fellow writer and friend, Sidonius Apollinaris. In his extant writings, Sidonius presents a sympathetic and, indeed, impressive image of his friend as both a devout member of the Christian community and an outstanding intellectual. Both the letters to Mamertus and the eulogy written after his death testify to the friendship between the two writers, and the intellectual, spiritual, and personal qualities of Claudianus Mamertus. Sidonius’ works concerning Mamertus are often analysed to underscore the philosophical and theological character of Mamertus’ work; yet their elegant form and their deep connection to cultural tradition deserves also an analysis from a more aesthetic, literary point of view.
From California dreaming to California data: Challenging historic models for landfill CH4 emissions
Authors: Spokas Kurt , Bogner Jean , Corcoran Meg , Walker Scott 
Published: June 2015

Abstract
Improved quantification of diverse CH4 sources at the urban scale is needed to guide local GHG mitigation strategies in the Anthropocene. Herein, we focus on landfill CH4 emissions in California, challenging the current IPCC methodology which focuses on a climate dependency for landfill CH4 generation (methanogenesis), but does not explicitly consider climate or soil dependencies for emissions. Relying on a comprehensive California landfill database, a field-validated process-based model for landfill CH4 emissions (CALMIM), and select field measurements at 10 California sites with a variety of methods, we support the contrary position: Limited climate dependency for methanogenesis, but strong climate dependency for landfill CH4 emissions. Contrary to the historic IPCC empirical model for methanogenesis with kinetic constants related to climate, we demonstrate a simpler and more robust linear empirical relationship (r2 = 0.85; n=128) between waste mass and landfill biogas recovery [126 × 10-6 Nm3 CH4 hr-1 Mgwaste-1]. More interestingly, there are no statistically significant relationships with climate, site age, or status (open/closed) for landfill biogas recovery. The current IPCC methodology does not consider soil or climate drivers for gaseous transport or seasonal methanotrophy in different cover soils. On the other hand, we illustrate strong climate and soil dependencies for landfill emissions—e.g., average intermediate cover emissions below 20 g CH4 m-2 d-1 when the site’s mean annual precipitation is &gt;500 mm y-1. Thereby, for the California landfill CH4 inventory, the highest-emitting sites shift from landfills containing the largest mass of waste to sites dominated by intermediate cover types having a reduced rate of soil CH4 oxidation during the annual cycle. These differences have profound implications for developing more realistic, science-based urban and regional scale GHG inventories for landfill CH4 while reducing uncertainties for this important anthropogenic source.
The design process of a reading comprehension manual
Authors: Lopera Medina Sergio Alonso 
Published: June 2015

Material design is an important part in the teaching practices. This article describes the process of material design of a foreign language (FL) reading manual for undergraduate students at Universidad de Antioquia (Medellín – Colombia). A case study was used as a research method. Four in-service English teachers based their inquiry following the reflective approach of professional development. They also took into account the guidelines to design teaching materials proposed by Howard and Major (2004). Some of the results of their inquiry for the design of the manual involve contextualization, personalization, and students’ needs. A sample of a reading strategy is given in order to illustrate how teachers worked and designed the manual as a product of their inquiry. Conclusions suggest that this professional development practice helped teachers become more aware of their own teaching realities and also helped them to understand their beliefs and practice in teaching reading as a foreign language.
Coloración Psicodélica de Imágenes Digitales mediante Lógica Difusa
Authors: Castro Linda Sheriyn Rodríguez , Fajardo Iván Javier Ponce , Cuchango Helbert Eduardo Espitia 
Published: June 2015

<p>En el presente artículo se propone un sistema de inferencia difusa para la manipulación del color en imágenes digitales con el propósito de modificar su estilo artístico. Se genera una combinación de colores diferente a la original de tal forma que produzca una nueva sensación visual. El sistema de lógica difusa propuesto, modela mediante conjuntos y reglas de inferencia difusas, la modificación de color considerando la modalidad artística denominada arte psicodélico, generando como resultado imágenes cuyos colores producen este efecto. En la segunda parte se afina el sistema de inferencia propuesto según datos empíricos determinados junto con expertos en el campo del arte, con el fin de obtener un mejor ajuste a la escala de colores del estilo artístico estudiado. Mediante la presentación de diferentes casos de prueba se evidencian los resultados obtenidos por el sistema antes y después de la optimización. </p>
Diseño de un dispositivo para la movilidad de personas con discapacidad motriz usando el método función de calidad
Authors: Bravo Leonardo Contreras 
Published: June 2015

<p>Este articulo muestra el desarrollo y selección de un diseño para generar un dispositivo de movilidad para personas con discapacidad motriz entre 8 a 15 años, con patologías T12 y que no tengan patologías concomitantes en miembros superiores. Inicia con la obtención de los requerimientos del cliente, y la transformación de estas a partir de la herramienta llamada función de calidad (Q.F.D - Quality Function Deployment), y el uso de diferentes métodos evaluación que finalizan condensando todos los distintos elementos a favor de las dos partes: la del cliente y la del productor.</p><p> </p><p>Después de descifrar de una manera cuantitativa lo cualitativo, se procede a desarrollar un proceso sistémico que genere elementos particulares para llegar a concretar el diseño por medio de pasos que unen los elementos técnicos y los requisitos del cliente (usuario).</p><p> </p><p>En la parte final, Se selecciona un modelo, se realiza un bosquejo con el cual represente el resultado de una manera gráfica y clara cuales fueron las elecciones realizadas por medio de la herramienta llamada función de calidad (Q.F.D).</p>
Modelamiento de estaciones TransMilenio mediante Autómatas Celulares: lecciones aprendidas
Authors: Rodríguez Garzón Camilo Alfonso 
Published: June 2015

<div class="page" title="Page 1"><div class="layoutArea"><div class="column"><p><span>Partiendo de un modelo que permite simular el congestionamiento en una estacio ́n de TransMilenio, se presenta una reflexio ́n acerca de las consecuencias del uso del paradig- ma utilizado (auto ́matas celulares), as ́ı como de aspectos idiosincra ́ticos que repercuten en el modelo. Se discuten simulta ́neamente los desaf ́ıos te ́cnicos e intelectuales que ello implica: simular las complejidades de un sistema en apariencia simple, pero que exhibe una enorme diversidad de comportamientos y variables plantea afrontar nuevos enfoques y te ́cnicas. El Ingeniero, bajo su status quo en la sociedad, debe replantear sus esque- mas y combinar disciplinas tradicionales y emergentes para enfrentar dichos retos. La experiencia que se recopila, da cuenta de ello. </span></p></div></div></div>
Aspectos técnicos y normativos para el monitoreo y medición de armónicos
Authors: Rojas Cubides Herbert Enrique , Rivas Trujillo Edwin , Jaramillo Matta Adolfo Andrés 
Published: June 2015

<p>En este artículo se presenta un análisis acerca de los parámetros requeridos para un adecuado proceso de monitoreo y medición de armónicos presentes en las redes de energía eléctrica, para estudios de calidad de potencia. Inicialmente se introducen conceptos básicos de los armónicos presentes en las redes de energía eléctrica, posteriormente se mencionan las normas y recomendaciones de regulación para la calidad de energía eléctrica en el marco colombiano. Seguido a esto se presentan algunos parámetros importantes que deben ser tenidos en cuenta para una adecuada adquisición y tratamiento de las señales de tensión y corriente tanto a frecuencia fundamental como a frecuencias armónicas, donde se hace énfasis en puntos como: medición de armónicos, determinación del punto de acople o conexión común (PCC), correcta ubicación de los sensores y registradores, equipos de medición de calidad de potencia, frecuencia de muestreo, intervalos de observación, transductores, medición de armónicos de tensión, medición de armónicos de corriente y condiciones del sistema durante la medición..</p>
The Political Economy of the Implementation of the Bankruptcy Law of China
Authors: Zuofa Wang 
Published: June 2015

Abstract
The implementation of the bankruptcy law of China deviates much from the expectation of the legislature. This article draws on political economy analysis, especially the interest group approach, to provide an explanation of the causes of the deviation and predict what the future of the modification and reform of the law might be. This article also describes the China context in using public choice theory to explain legal issues.
Continuous Local Analgesia in Postoperative Treatment of Large Incisional Hernias – Preliminary Results
Authors: Gherghinescu M. , Molnar C. , Popa D. , Russu C. , Copotoiu C. 
Published: June 2015

Abstract
Background: The incisional hernias are frequent complications after laparotomy. Extended subcutaneous tissue dissection is often necessary for the treatment of large incisional hernias, and this procedure is frequently followed by a high intensity pain in the postoperative period. The aim of this study was to assess the postoperative patient comfort without using major analgesics.
Material and method: we present the preliminary results of an ongoing study from Surgery Clinic 1 of Emergency Clinical County Hospital of Târgu Mures, University of Medicine and Pharmacy Târgu Mures. The study comprises in the intraoperative insertion of a subcutaneous catheter (Pajunk InfiltraLong) placed on lay, through which we administered continuously Ropivacaine 0,5%.
Results: Ten patients have been included in the study by now. For 5 of the patients the wound infiltration was started with 7 ml/h in the first 6 postoperative hours, after which the rate decreased to 5 ml/h until the end of the 72 hours, when the catheter was removed. For 2 patients the wound infiltration was started with 10ml/h in the first 6 postoperative hours, after which the rate decreased to 7 ml/h in the first day, followed by 5 ml/h for the next two days. Two patients needed a minor analgesic in the immediate postoperative period and one patient needed major analgesia in the first 24 hours.
Conclusions: By using this method, postoperative analgesia can be achieved without using major systemic analgesics and a superior patient comfort can be achieved simply by adjusting the infusion rate
Redescription and phylogenetic relationships of the rare Lyperosomum sarothrurae Baer, 1959 (Digenea: Dicrocoeliidae)
Authors: Hildebrand Joanna , Pulis Eric E. , Tkach Vasyl. V. 
Published: June 2015

AbstractLyperosomum sarothrurae Baer, 1959 is a rare dicrocoeliid described based on a single specimen from Belgian Congo, now Democratic Republic of the Congo, and never reported again. The original description lacked several important details of the species morphology. This work provides morphological redescription of Lyp. sarothrurae based on specimens from Kibale National Park, Uganda which is about 200 kilometres from the type locality. Results of re-examination of the holotype are also provided. Morphology of Lyp. sarothrurae shows some characteristics intermediate between those of the species rich genus Lyperosomum Looss, 1899 and Megacetabulum Oshmarin, 1964 that includes only 3 species. Due to the lack of clear morphological differences between the two genera, Megacetabulum is considered here as a junior synonym of Lyperosomum. Molecular phylogenetic analysis including Lyp. sarothrurae and all currently available partial sequences of the nuclear ribosomal 28S RNA gene of dicrocoeliid species is also included and its results are discussed
A new Cosmocercoides species (Nematoda: Cosmocercidae), C. tonkinensis n. sp., in the scale-bellied tree lizard (Acanthosaura lepidogaster) from Vietnam
Authors: Tran Binh Thi , Sato Hiroshi , Luc Pham Van 
Published: June 2015

AbstractA new cosmocercid nematode species, Cosmocercoides tonkinensis n. sp., is described from the scale-bellied tree lizard (Acanthosaura lepidogaster) in the northern and central parts of Vietnam. The new species is characterized by medium-sized male worms (4.2-5.1 mm in length and 0.34-0.37 mm in width) relative to known members of the genus, with lateral alae, two sharply pointed spicules of equal length (0.22-0.26 mm in length), a gubernaculum (0.113-0.122 mm in length), 16 or 17 pairs of caudal rosettes, and the presence of somatic papillae. Female worms are slightly larger than male worms (5.3-5.5 mm in length and 0.32-0.42 mm in width), with the vulva situated at 3/5 from the anterior end, and elliptical embryonated eggs, 0.064- 0.084 mm long by 0.040-0.048 mm wide. From 19 recorded species of the genus, the morphology of C. tonkinensis n. sp. is closest to C. multipapillata, C. bufonis, and C. pulcher reported from toads and frogs in East Asia. The present new species is differentiated from them by the number of caudal rosettes, tail length relative to body length, presence of somatic papillae and lateral alae, and embryonated eggs. Furthermore, after C. variabilis in North America and C. sauria in Brazil, this new species is only the third species to be recorded from a reptilian host. The 18S ribosomal RNA gene (rDNA) of the new species is almost identical to that of C. dukae infecting land snails and slugs in North America. Between the present new species and C. pulcher from a toad (Bufo japonicus) in Japan, remarkably fewer nucleotide changes were noticed in the 18S to 28S rDNA including the internal transcribed spacer regions. The molecular phylogenetic position of the genus Cosmocercoides is briefly discussed.