bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of venous sinus, tumor location, and pial supply during meningioma surgery by transdural indocyanine green videography
Authors: Ueba Tetsuya , Okawa Masakazu , Abe Hiroshi , Nonaka Masani , Iwaasa Mitsutoshi , Higashi Toshio , Inoue Tooru , Takano Koichi 
Published: January 2013

Object
Indocyanine green (ICG) videography is commonly used in the neurosurgical field for minimally invasive neurosurgery. The aim of this study was to evaluate a new intraoperative imaging modality by performing transdural ICG videography during surgery for meningiomas.

Methods
Between March 2011 and April 2012, 10 patients with meningiomas received intravenous injection of 12.5 mg ICG just prior to dural opening. The cases comprised 8 convexity meningiomas and 2 foramen magnum meningiomas. Efficacy of the transdural ICG videography was assessed in terms of the tumor volume, the circulation time from the first appearance of the vessel to the appearance of the venous sinus, the tendency to bleed, and the discrimination of the venous sinus.

Results
The mean tumor volume was 71.6 ± 87.9 ml (the mean is expressed ± SD throughout). The cortical arteries, veins, and the venous sinus were identified by the ICG videography transdurally. The projection of the meningiomas was identified by a shadow (which the authors call the eclipse sign). Total eclipse signs were obtained in 8 cases and partial eclipse signs were obtained in 2 cases; tumor volume in the latter was more than 200 ml. In 5 of 10 cases the adjacent venous sinuses were exposed and were successfully visualized by ICG videography in 5.92 ± 1.05 seconds from the first appearance of the vessel. In 5 of 10 cases the total and the partial eclipse signs were diminished in 3.46 ± 1.31 seconds. The diminishment of the total and the partial eclipse sign was earlier than the visualization of the venous sinus (p = 0.011, t-test), revealing bleeding from the tumor that was observed until coagulation of the feeding arteries from the intracranial arteries.

Conclusions
Prior to opening of the dura mater, transdural ICG videography was used successfully to visualize the dural attachment of meningiomas and the venous sinus, resulting in safe and appropriate dural opening. The diminishment of the total and partial eclipse signs may represent significant feeding from the intracranial arteries and a tendency to bleed during resection.
Enhanced antitumor effect of YM872 and AG1296 combination treatment on human glioblastoma xenograft models
Authors: Watanabe Takashi , Ohtani Toshiyuki , Aihara Masanori , Ishiuchi Shogo 
Published: January 2013

Object
Blockade of Ca++-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor (AMPAR) inhibits the proliferation of human glioblastoma by inhibiting Akt phosphorylation, which is independent of the phosphatidylinositol 3-kinase pathway. Inhibiting platelet-derived growth factor receptor (PDGFR)–mediated phosphorylation causes growth inhibition in glioblastoma cells. The authors of this study investigated the effects of YM872 and AG1296, singly and in combination and targeting different pathways upstream of Akt, on Akt-mediated tumor growth in glioblastoma cells in vivo and in vitro.

Methods
The expression of AMPAR, PDGFR, and c-kit in glioblastoma cells was analyzed via immunofluorescence. Glioblastoma cells, both in culture and in xenografts grown in mice, were treated with YM872 and AG1296, singly or in combination. Inhibition of tumor growth was observed after treatment in the xenograft model. Cell proliferation assays were performed using anti–Ki 67 antibody in vivo and in vitro. The CD34-positive tumor vessel counts within the vascular hot spots of tumor specimens were evaluated. Phosphorylation of Akt was studied using Western blot analysis.

Results
Combined administration of YM872 and AG1296 had a significant enhanced effect on the inhibition of cell proliferation and reduction of tumor vascularity in the xenograft model. These agents singly and in combination demonstrated a significant reduction of Akt phosphorylation at Ser473 and inhibition of tumor proliferation in vitro, although combined administration had no enhanced antitumor effects.

Conclusions
The strongly enhanced antitumor effect of this combination therapy in vivo rather than in vitro may be attributable to disruption of the aberrant vascular niche. This combination therapy might provide substantial benefits to patients with glioblastoma.
Prognosis by tumor location in adults with spinal ependymomas
Authors: Oh Michael C. , Kim Joseph M. , Kaur Gurvinder , Safaee Michael , Sun Matthew Z. , Singh Anahat , Aranda Derick , Molinaro Annette M. , Parsa Andrew T. 
Published: January 2013

Object
Ependymomas are primary central nervous system tumors that occur more frequently in the spines of adults than they do there in children. Previous studies consist mainly of retrospective single-institutional experiences or case studies. In this study, a comprehensive literature review was performed on reported cases of spinal ependymoma treated with resection to determine whether tumor location along the spinal axis conveys important prognostic information.

Methods
A PubMed search was performed to identify all papers that included data on patients with spinal ependymoma. Only cases involving adult patients who underwent ependymoma resection with a clearly reported tumor location were included for analysis. Tumor locations were separated into 6 groups: cervicomedullary, cervical, cervicothoracic, thoracic, thoracolumbar, and conus + cauda equina. Kaplan-Meier survival and Cox regression analyses were performed to determine the effect of tumor location on progression-free survival (PFS) and overall survival (OS).

Results
A total of 447 patients who underwent resection of spinal ependymomas with clearly indicated location of tumor were identified. The most common locations of spinal ependymomas were the cervical (32.0%) and conus + cauda equina (26.8%) regions. The thoracolumbar and cervicomedullary regions had the fewest tumors (accounting for, respectively, 5.1% and 3.4% of the total number of cases). The conus + cauda equina and thoracolumbar regions had the highest percentage of WHO Grade I tumors, while tumors located above these regions consisted of mostly WHO Grade II tumors. Despite the tendency for benign grades in the lower spinal regions, PFS for patients with spinal ependymomas in the lower 3 regions (thoracic, thoracolumbar, conus + cauda equina) was significantly shorter (p < 0.001) than for those with tumors in the upper regions (cervicomedullary, cervical, cervicothoracic), but the difference in OS did not achieve statistical significance (p = 0.131).

Conclusions
Spinal ependymomas along different regions of spinal axis have different characteristics and clinical behaviors. Tumor grade, extent of resection, and PFS varied by tumor location (upper vs lower spinal regions), while OS did not. Recurrence rates were higher for the lower spinal cord tumors, despite a greater prevalence of lower WHO grade lesions, compared with upper spinal cord tumors, suggesting that tumor location along the spinal axis is an important prognostic factor.
Visual Outcomes and Safety of a Refractive Corneal Inlay for Presbyopia Using Femtosecond Laser
Authors: Limnopoulou Aliki N. , Bouzoukis Dimitrios I. , Kymionis George D. , Panagopoulou Sophia I. , Plainis Sotiris , Pallikaris Aristophanes I. , Feingold Vladimir , Pallikaris Ioannis G. 
Published: January 2013

PURPOSE:
To evaluate the outcomes and safety of a refractive inlay (Flexivue Micro-Lens, Presbia Coöperatief U.A.) for the corneal compensation of presbyopia.

METHODS:
This prospective, interventional clinical study comprised 47 emmetropic presbyopes with a mean age of 52±4 years (range: 45 to 60 years). The inlay was inserted, centered on the line of sight, inside a corneal pocket created in the patient’s nondominant eye, using a femtosecond laser. Follow-up was 12 months. Visual acuity, corneal topography, wavefront aberrometry, contrast sensitivity, structural corneal alterations, and questionnaires were evaluated.

RESULTS:

Twelve months after surgery, uncorrected near visual acuity was 20/32 or better in 75% of operated eyes, whereas mean uncorrected distance visual acuity (UDVA) of operated eyes was statistically significantly decreased from 0.06±0.09 logMAR (20/20) (range: −0.08 to 0.26) preoperatively to 0.38±0.15 logMAR (20/50) (range: 0.12 to 0.8) (
P
<.001), and mean binocular UDVA was not significantly altered (
P
=.516). Seventeen patients lost one line of corrected distance visual acuity in the operated eye. No patient lost 2 lines in CDVA in the operated eye. Overall, higher order aberrations increased and contrast sensitivity decreased in the operated eye. No tissue alterations were found using corneal confocal microscopy. No intra- or postoperative complications occurred.

CONCLUSIONS:
Twelve months after implantation, the Flexivue Micro-Lens intracorneal refractive inlay seems to be an effective method for the corneal compensation of presbyopia in emmetropic presbyopes aged between 45 and 60 years old.
Topography-guided Transepithelial PRK After Intracorneal Ring Segments Implantation and Corneal Collagen CXL in a Three-Step Procedure for Keratoconus
Authors: Coskunseven Efekan , Jankov Mirko R. , Grentzelos Michael A. , Plaka Argyro D. , Limnopoulou Aliki N. , Kymionis George D 
Published: January 2013

PURPOSE:
To present the results of topography-guided transepithelial photorefractive keratectomy (PRK) after intracorneal ring segments implantation followed by corneal collagen cross-linking (CXL) for keratoconus.

METHODS:
In this prospective case series, 10 patients (16 eyes) with progressive keratoconus were included. All patients underwent topography-guided transepithelial PRK after Keraring intracorneal ring segments (Mediphacos Ltda) implantation, followed by CXL treatment. The follow-up period was 6 months after the last procedure for all patients. Time interval between both intracorneal ring segments implantation and CXL and between CXL and topography-guided transepithelial PRK was 6 months.

RESULTS:

LogMAR mean uncorrected distance visual acuity and mean corrected distance visual acuity were significantly improved (
P
<.05) from 1.14±0.36 and 0.75±0.24 preoperatively to 0.25±0.13 and 0.13±0.06 after the completion of the three-step procedure, respectively. Mean spherical equivalent refraction was significantly reduced (
P
<.05) from −5.66±5.63 diopters (D) preoperatively to −0.98±2.21 D after the three-step procedure. Mean steep and flat keratometry values were significantly reduced (
P
<.05) from 54.65±5.80 D and 47.80±3.97 D preoperatively to 45.99±3.12 D and 44.69±3.19 D after the three-step procedure, respectively.

CONCLUSIONS:
Combined topography-guided transepithelial PRK with intracorneal ring segments implantation and CXL in a three-step procedure seems to be an effective, promising treatment sequence offering patients a functional visual acuity and ceasing progression of the ectatic disorder. A longer follow-up and larger case series are necessary to thoroughly evaluate safety, stability, and efficacy of this innovative procedure.
Reduced Cross-linking Demarcation Line Depth at the Peripheral Cornea After Corneal Collagen Cross-linking
Authors: Yam Jason C. S. , Cheng Arthur C. K. 
Published: January 2013

PURPOSE:
To compare the corneal collagen cross-linking (CXL) demarcation line depth between the central and peripheral cornea after cross-linking using anterior segment optical coherence tomography.

METHODS:
Retrospective interventional case series of 38 eyes with keratoconus or postoperative LASIK ectasia treated with riboflavin ultraviolet A CXL (UV-X, IROC). CXL demarcation line depth, corneal thickness, and the ratio of the CXL demarcation line depth to the corneal thickness were measured using anterior segment optical coherence tomography at the central cornea and at 2 and 4 mm from the corneal center in four regions: temporal, nasal, superior, and inferior. The CXL demarcation line depths at the center and periphery were compared using the Friedman test.

RESULTS:

The CXL demarcation line was deepest in the central cornea (302 μm; range: 180 to 397 μm) and was reduced progressively toward the peripheral cornea, at nasal 2 mm (289.5 μm; range: 125 to 370 μm), at nasal 4 mm (206.5 μm; range: 100 to 307 μm), at temporal 2 mm (278.5 μm; range: 128 to 375 μm), and at temporal 4 mm (194 μm; range: 80 to 325 μm) (
P
<.001). The penetration proportion was greatest at the central cornea (64.8%; range: 44% to 80%) and was decreased toward the periphery, at nasal 2 mm (53.8%; range: 30% to 74%), at nasal 4 mm (33.8%; range: 19% to 53%), at temporal 2 mm (54.1%; range: 29% to 77%), and at temporal 4 mm (34.1%; range: 15% to 54%) (
P
⩽.001).

CONCLUSIONS:
Both the CXL demarcation line depth and its proportion over the corneal thickness were greater at the central cornea than the peripheral cornea.
Intracorneal Ring Segments Implantation Followed by Same-day Topography-guided PRK and Corneal Collagen CXL in Low to Moderate Keratoconus
Authors: Al-Tuwairqi Waleed , Sinjab Mazen M. 
Published: January 2013

PURPOSE:
To evaluate the safety and efficacy of intrastromal corneal ring segments (ICRS) implantation followed by same-day topography-guided photorefractive keratectomy (PRK) and ultraviolet-A/riboflavin collagen cross-linking (CXL) in patients with low to moderate keratoconus.

METHODS:
Patients with low to moderate keratoconus and contact lens intolerance were included in the study. All patients first underwent femtosecond laser–enabled placement of ICRS (Keraring, Mediphacos) (first step). Same-day topography-guided PRK and CXL (second step) were subsequently performed in all patients after the refraction was stable (average 6 months [range: 3 to 11 months]).

RESULTS:

Thirteen eyes from 13 patients were included in the study. Based on values before the first step and 6 months after the second step, significant improvements were noted in uncorrected distance visual acuity (0.7±0.32 logMAR vs 0.08±0.08 logMAR), corrected distance visual acuity (CDVA) (0.16±0.19 logMAR vs 0.02±0.04 log-MAR), sphere (−3.65±3.08 diopters [D] vs 0.06±1.6 D), astigmatism (−3.31±1.5 D vs −0.98±0.75 D), average K (47.28±1.99 D vs 41.42±3.22 D), and coma (2.36±1.23
μ
m vs 1.47±0.68
μ
m) (
P
<.05). Approximately 63% of eyes gained ⩾2 lines of CDVA, whereas no change in CDVA was reported in ∼27% of eyes. No eyes lost lines of CDVA.

CONCLUSIONS:
The combination of ICRS implantation followed by sequential same-day topography-guided PRK/CXL may be a reasonable option for improving visual acuity in patients with low to moderate keratoconus.
Assessment of Corneal Biomechanical Behavior Under Posterior and Anterior Pressure
Authors: Yu Ji-guo , Bao Fang-jun , Feng Yi-fan , Whitford Charles , Ye Ting , Huang Yan-bing , Wang Qin-mei , Elsheikh Ahmed 
Published: January 2013

PURPOSE:
To determine the biomechanical response of the rabbit cornea to inflation under posterior and anterior pressure.

METHODS:
Twelve Japanese white rabbits were included in the study. A randomly selected eye from each animal was subjected to posterior pressure in an inflation test rig, and the other eye was subjected to anterior pressure after manually reversing its curvature. Specimens were loaded by cycles of pressure up to 40 mmHg, and the experimentally obtained pressure-deformation data were used to derive the stress–strain behavior of each eye using an inverse modeling procedure.

RESULTS:

The differences between the two groups in corneal thickness, diameter, and intraocular pressure (IOP) were not statistically significant (
P
=.935, .879 and .368, respectively). Corneas tested under posterior pressure displayed significantly higher stiffness (as measured by the tangent modulus) than those inflated by anterior pressure (
P<
.001).

CONCLUSIONS:
Cornea is a nonlinear viscoelastic tissue that presents different mechanical properties when tested under posterior and anterior pressure. The determination of the behavior under both forms of pressure could contribute to the construction of accurate finite element simulations of corneal behavior and the correction of tonometric IOP measurements. The difference in mechanical behavior between anteriorly and posteriorly loaded corneas in the study, although significant, could have been partly affected by the changes in microstructure possibly caused by changing corneal form to enable anterior loading.
The Policy Trajectory of United States Asteroid Deflection Planning
Authors: Packer Joseph , Kurr Jeffrey A. , Abelkop Adam 
Published: January 2013

Recent scientific studies document how potential dangers posed by asteroid collisions with Earth have been previously underestimated. These findings are alarming given the prevailing trajectory of US asteroid deflection policy, characterized by uncritical reliance on scientifically questionable deflection methods, such as nuclear interception. Numerous intercollegiate policy debate contests provided the authors with opportunities to survey the relevant policy literature and test alternative proposals for asteroid deflection planning. This article translates the results of the interactive research, reflecting on the historical backdrop of the threat posed to the planet by near-Earth Objects (NEOs), considering the relative merits of proposed deflection policies, exploring the issue’s connection with ballistic missile defense debates, and finally offering a call to action.
<b>O estágio curricular e a didática na formação de professores: desafios e possibilidades</b>
Authors: Girotto Cyntia Graziella Guizelim Simões , Castro Rosane Michelli de 
Published: January 2013

http://dx.doi.org/10.5902/198464444094 Neste artigo enfocamos aspectos das disciplinas do curso de Pedagogia “estágio curricular” e “didática” na formação de professores. O objetivo central é ressaltar, mediante apresentação do trabalho que realizamos em nossa prática docente nas disciplinas mencionadas, a importância da articulação entre a teoria e a prática na formação de professores e a fim de que o ensino na universidade não seja descontextualizado, mas enriquecido com as questões do cotidiano escolar. Nesse sentido, abordamos, inicialmente, aspectos do estágio curricular como elo mediador de aprendizagem, de articulação do currículo e de práticas e, nessa perspectiva, como um canal produtivo entre a universidade e a Educação Básica, ressaltando a necessidade do acolhimento da contribuição que cada uma das instituições, dentro de sua especificidade, deva oferecer nos cursos de formação. Na sequência, apresentamos aspectos da estrutura do trabalho que desenvolvemos com nossos alunos no estágio curricular na Educação Infantil. Finalmente, explicitamos os aspectos de uma didática voltada para a formação de professores da Educação Infantil e dos anos iniciais do Ensino Fundamental, centrada em narrativas de professores em serviço, sobre suas vivências e experiências docentes, em busca de novas sistematizações da e sobre a prática pedagógica, pelos próprios sujeitos. Palavras-chave: formação de professores, estágio curricular, didática.
<b>A elaboração da experiência da docência nos anos iniciais do Ensino Fundamental</b>
Authors: Toscano Carlos 
Published: January 2013

http://dx.doi.org/10.5902/198464444628 Neste trabalho, apresenta-se e discute-se parte dos resultados de uma pesquisa que foi realizada entre 2006 e 2009 com alunas egressas do curso de Pedagogia que se tornaram professoras. Tal estudo tomou como referência as contribuições teóricas e metodológicas de Bakhtin, Lahire e Chartier, levando-se em conta que estes autores, em suas especificidades, situam nas práticas sociais a gênese do especificamente humano, destacando o papel do outro e da mediação semiótica nesse processo. Os dados aqui compartilhados referem-se a um dos sujeitos desta pesquisa, que, à época, era professora do terceiro ano do Ensino Fundamental em uma instituição pública de ensino no interior do Paraná e diz respeito ao relato desta experiência profissional. Seu estudo, ao pretender contribuir para ampliar a visibilidade dos processos constitutivos da profissionalidade docente nos anos iniciais, acabou colocando em evidência um entrelaçamento singular de várias vozes sociais que se encontram, confrontam-se e se localizam em diversos espaços e tempos: algumas delas pertencem ao período da sua formação inicial, mediadas pelos professores formadores; outras pertencem aos seus interlocutores imediatos, colegas de trabalho/equipe pedagógica; além de vozes que se localizam na administração local, que, por sua vez, mediam a política educacional, indiciando as determinações mais amplas que marcam uma determinada época histórica. Palavras-chave: cotidiano escolar, trabalho docente, significações, anos iniciais do Ensino Fundamental.
<b>O corpo docente masculino: suas variações e (in)conformidades</b>
Authors: Rosa Rogério Machado , Lima Patrícia Moraes 
Published: January 2013

http://dx.doi.org/10.5902/198464444824 Nesse texto buscamos cartografar, a partir de uma interlocução com autores como Deleuze e Guattari e Nietzsche, o processo de variação-deslocamento-multiplicação do corpo masculino docente, a estética das sensibilidades e os agenciamentos corporais que os encontros pedagógicos inspiram. O corpo-docente-masculino, suas variações e (in)conformidades, será tomado como plano de inscrição e veículo das forças afectivas e vibratórias que por ele passa e o coloca em movimento de territorialização, desterritorialização e reterritorialização. Problematizaremos, assim, o lugar do encontro pedagógico como possível dispositivo maquínico, apontando para a ideia de que os agenciamentos produzidos a partir daí operam na criação de experimentações corporais que deslocam o corpo masculino dos lugares consagrados pela norma e o aproxima do corpo-masculino-marginal, prenhe de devires e (des)organizado: corpo sem orgãos. Palavras-chave: corpo, docência, masculinidades, criação.
<b>O laptop educacional na escola pública: letramento digital e possibilidades de transformação das práticas pedagógicas</b>
Authors: Valentini Carla Beatris , Pescador Cristina Maria , Do Sacramento Soares Eliana Maria 
Published: January 2013

http://dx.doi.org/10.5902/198464445624 A presença dos laptops educacionais na rotina de estudantes e professores pode contribuir para a transformação das práticas pedagógicas vigentes. Nesse sentido, o presente trabalho parte da ideia de que a inserção dos laptops educacionais, na modalidade 1:1, pode ser um elemento perturbador, desencadeando um processo de reflexão e possível tomada de consciência do fazer docente por parte dos professores. Isso poderia levar a um redimensionamento de sua conduta docente em um movimento de incluir o laptop no cotidiano escolar de forma significativa. Apresentamos um estudo de caso, de cunho exploratório, da inserção do laptop em uma escola pública de ensino fundamental, analisando o processo de letramento digital dessa comunidade escolar. Assim, o letramento digital implica na interação em redes sociais que permitem a exploração e a pesquisa, em um processo de ensinar e aprender em que a construção do conhecimento é mediada pelas tecnologias digitais. Para isso, a partir da não-linearidade que acompanha os fluxos de comunicação emergentes dessas tecnologias, estudantes e professores são instigados a buscar novos significados, em que a leitura e escrita consiste em compartilhar conhecimento e opiniões e não apenas uma tarefa a ser entregue. Palavras-chave: letramento digital; tecnologias digitais; aprendizagem.