bluuebunny/crossref_metadata_2025_split huggingface dataset:
Total Oxidant Status and Bone Resorption Biomarkers in Serum and Gingival Crevicular Fluid of Patients With Periodontitis
Authors: Baltacıoğlu Esra , Kehribar Malike Aslan , Yuva Pınar , Alver Ahmet , Atagün Özlem Saraç , Karabulut Erdem , Akalın Ferda Alev 
Published: May 2013

Background: In this study, the relationships between total oxidant status (TOS) and receptor activator of nuclear factor‐κB ligand (RANKL) and osteoprotegerin (OPG) levels and RANKL/OPG ratios in serum and gingival crevicular fluid (GCF) are investigated in patients with chronic (CP) and generalized aggressive (GAgP) periodontitis.Methods: Thirty patients with CP, 30 patients with GAgP, and 28 periodontally healthy controls were included in the study. After clinical measurements and samplings, serum and GCF TOS, RANKL, and OPG levels were determined by a novel automatic colorimetric method and enzyme‐linked immunosorbent assays.Results: Serum and GCF TOS, RANKL, and RANKL/OPG values were higher in the periodontitis groups compared with controls, and they were also higher in the GAgP group than the CP group (except serum and GCF RANKL). Furthermore, serum and GCF OPG concentrations were lower in the periodontitis groups than in controls. Strong positive and negative correlations were observed between the periodontal parameters TOS and bone resorption biomarkers.Conclusions: The present results reveal that TOS, RANKL, and RANKL/OPG values are systemically and locally increased in periodontitis and that this increase is more evident in AgP than CP. These findings further suggest that oxidative stress is closely associated with the severity of periodontitis and bone resorption biomarkers.
Banting Lecture 2012
Authors: Spiegelman Bruce M. 
Published: May 2013

The Banting Medal for Scientific Achievement Award is the American Diabetes Association's highest scientific award and honors an individual who has made significant, long-term contributions to the understanding of diabetes, its treatment, and/or prevention.The award is named after Nobel Prize winner Sir Frederick Banting, who codiscovered insulin treatment for diabetes.
Bruce M. Spiegelman, PhD, of Harvard Medical School and the Dana-Farber Cancer Institute in Boston, received the American Diabetes Association's Banting Medal for Scientific Achievement at the Association's 72nd Scientific Sessions, 8–12 June 2012, Philadelphia, Pennsylvania. He presented the Banting Lecture, “Transcriptional Control of Adipogenesis—Toward a New Generation of Therapeutics for Metabolic Disease,” on Sunday, 10 June 2012. In his lecture, Dr. Spiegelman described the discovery of several transcriptional components that control adipose cell development: PPAR-γ, PGC1-α, and PRDM16. He also described the cloning and characterization of beige fat cells, the thermogenic “brown-like” cells that can develop in white fat depots. Lastly, Dr. Spiegelman discussed irisin, a newly discovered regulatory hormone that converts white fat into the more thermogenic beige fat. Dr. Spiegelman’s research has found that irisin, which is induced by exercise, appears to activate some of the same health benefits as exercise, including improvement of glycemic control. Understanding the regulation of adipose tissue, white, brown, and beige, can potentially lead to the development of a new generation of therapeutics for diabetes prevention and treatment.
Ethnic Differences in the Relationship Between Insulin Sensitivity and Insulin Response
Authors: Kodama Keiichi , Tojjar Damon , Yamada Satoru , Toda Kyoko , Patel Chirag J. , Butte Atul J. 
Published: May 2013

OBJECTIVE
Human blood glucose levels have likely evolved toward their current point of stability over hundreds of thousands of years. The robust population stability of this trait is called canalization. It has been represented by a hyperbolic function of two variables: insulin sensitivity and insulin response. Environmental changes due to global migration may have pushed some human subpopulations to different points of stability. We hypothesized that there may be ethnic differences in the optimal states in the relationship between insulin sensitivity and insulin response.

RESEARCH DESIGN AND METHODS
We identified studies that measured the insulin sensitivity index (SI) and acute insulin response to glucose (AIRg) in three major ethnic groups: Africans, Caucasians, and East Asians. We identified 74 study cohorts comprising 3,813 individuals (19 African cohorts, 31 Caucasian, and 24 East Asian). We calculated the hyperbolic relationship using the mean values of SI and AIRg in the healthy cohorts with normal glucose tolerance.

RESULTS
We found that Caucasian subpopulations were located around the middle point of the hyperbola, while African and East Asian subpopulations are located around unstable extreme points, where a small change in one variable is associated with a large nonlinear change in the other variable.

CONCLUSIONS
Our findings suggest that the genetic background of Africans and East Asians makes them more and differentially susceptible to diabetes than Caucasians. This ethnic stratification could be implicated in the different natural courses of diabetes onset.
Safety and Tolerability of the Treatment of Youth-Onset Type 2 Diabetes
Authors:   TODAY Study Group
Published: May 2013

OBJECTIVE
Data related to the safety and tolerability of treatments for pediatric type 2 diabetes are limited. The TODAY clinical trial assessed severe adverse events (SAEs) and targeted nonsevere adverse events (AEs) before and after treatment failure, which was the primary outcome (PO).

RESEARCH DESIGN AND METHODS
Obese 10- to 17-year-olds (N = 699) with type 2 diabetes for &lt;2 years and hemoglobin A1c (A1C) ≤8% on metformin monotherapy were randomized to one of three treatments: metformin, metformin plus rosiglitazone (M + R), or metformin plus lifestyle program (M + L). Participants were followed for 2–6.5 years.

RESULTS
Gastrointestinal (GI) disturbance was the most common AE (41%) and was lower in the M + R group (P = 0.018). Other common AEs included anemia (20% before PO, 14% after PO), abnormal liver transaminases (16, 15%), excessive weight gain (7, 9%), and psychological events (10, 18%); the AEs were similar across treatments. Permanent medication reductions/discontinuations occurred most often because of abnormal liver transaminases and were lowest in the M + R group (P = 0.005). Treatment-emergent SAEs were uncommon and similar across treatments. Most (98%) were unrelated or unlikely related to the study intervention. There were no deaths and only 18 targeted SAEs (diabetic ketoacidosis, n = 12; severe hypoglycemia, n = 5; lactic acidosis, n = 1). There were 62 pregnancies occurring in 45 participants, and 6 infants had congenital anomalies.

CONCLUSIONS
The TODAY study represents extensive experience managing type 2 diabetes in youth and found that the three treatment approaches were generally safe and well tolerated. Adding rosiglitazone to metformin may reduce GI side effects and hepatotoxicity.
Treatment Effects on Measures of Body Composition in the TODAY Clinical Trial
Authors:   TODAY Study Group
Published: May 2013

OBJECTIVE
The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) trial showed superiority of metformin plus rosiglitazone (M+R) over metformin alone (M), with metformin plus lifestyle (M+L) intermediate in maintaining glycemic control. We report here treatment effects on measures of body composition and their relationships to demographic and metabolic variables including glycemia.

RESEARCH DESIGN AND METHODS
Measures of adiposity (BMI, waist circumference, abdominal height, percent and absolute fat, and bone mineral content [BMC] and density [BMD]) were analyzed as change from baseline at 6 and 24 months.

RESULTS
Measures of fat accumulation were greatest in subjects treated with M+R and least in M+L. Although fat measures in M+L were less than those of M+R and M at 6 months, differences from M were no longer apparent at 24 months, whereas differences from M+R persisted at 24 months. The only body composition measure differing by race and/or ethnicity was waist circumference, greater in M+R than either M or M+L at both 6 and 24 months in whites. BMD and BMC increased in all groups, but increased less in M+R compared with the other two groups by 24 months. Measures of adiposity (increases in BMI, waist circumference, abdominal height, and fat) were associated with reduced insulin sensitivity and increased hemoglobin A1c (HbA1c), although effects of adiposity on HbA1c were less evident in those treated with M+R.

CONCLUSIONS
Despite differential effects on measures of adiposity (with M+R resulting in the most and M+L in the least fat accumulation), group differences generally were small and unrelated to treatment effects in sustaining glycemic control.
Comparison of ice stress records in terms of extreme value analysis
Authors: Lensu Mikko , Elder Bruce C. , Richter-Menge Jackie , Haapala Jari 
Published: May 2013

AbstractDynamic ice models use stress tensor to describe the forces arising from internal ice friction. The model stress values are typically one to two magnitudes smaller than values measured by stressmeters deployed on ice floes. The synthesis of the pack-ice stress state from the measurements has been complicated by the peaky character of stress records, and the means to connect them with spatial stress distribution of the floe system have been lacking. Here a reanalysis of Arctic Sea Ice Mechanics Initiative (SIMI) data is made in terms of extreme value statistics. The basic quantity is the maximum stress observed during a time period. The records exhibit self-affine scaling. The statistics are then determined by two parameters, the Hurst exponent H and a reference stress level. Similar analysis is possible for the kinematic data. This establishes the comparability of stress records with each other and with kinematic records. The results suggest that the exponent is related to the stress state of the regional floe system, while the stress level is determined by local floe characteristics. Based on this a characterization of spatial distribution of pack-ice stresses is given.
Subclinical mastitis in cattle in Algeria: Frequency of occurrence and bacteriological isolates
Authors: Saidi Radhwane , Khelef Djamel , Kaidi Rachid 
Published: May 2013

The present study was carried out to determine the prevalence of subclinical mastitis in cattle in eighteen herds in the center region of Algeria. Milk samples were collected from 560 quarters of 140 cows free of clinical mastitis. The samples were subjected to California Mastitis Test (CMT) and the positive samples were analysed by bacteriological culture and Speed ​​Mam® Color. The overall quarter prevalence was 28.77% whilst animal prevalence was 28.57%.Bacteriological analysis showed that there was a wide range of bacteria that cause these infections. Staphylococcus aureus (40%) was found to be the most prevalent organism followed by Streptococcus spp. (12.5%), Enterobacteriaceae (2.5%), Pseudomonas spp. (2.5%), Staphylococcusaureus + Streptococcus spp. (12.5%), Streptococcus spp.+ Escherichia coli (7.5%), S. aureus + Mycoplasma spp.(7.5%), and S. aureus +Streptococcus spp.+ E. coli (5%).
Bilateral Renal Infarction in a Lupus Patient: An Unusual Pathology
Authors: Padilla-Fernández Bárbara , García-Casado Diana , Martín-Izquierdo Manuela , Manzano-Rodríguez Carmen , García-García Javier , Lorenzo-Gómez María F. 
Published: May 2013

Acute renal infarction is still an underdiagnosed pathology. Most cases are secondary to arterial embolism in patients with atrial fibrillation or other cardiac illnesses; however, a less known etiology is the vascular affection of systemic lupus erythematosus (SLE). Renal infarction in lupus patients normally appears with positive antiphospholipid antibodies or lupus anticoagulant in the context of an antiphospholipid syndrome (APS). This is characterized by a state of hypercoagulability potentially affecting all segments of the vascular bed with thrombosis. A differential diagnosis with lupus nephritis, a very common pathology in SLE patients, must be carried out. We have to suspect this pathology in patients with SLE and APS who come to the emergency department complaining of abdominal pains or a renal colic. We present the case of a 69-year-old woman who was diagnosed of bilateral segmental renal infarction in the context of recently diagnosed SLE with no other vascular manifestations.
Twists of Shimura Curves
Authors: Stankewicz James 
Published: May 2013

AbstractConsider a Shimura curve XD0(N) over the rational numbers. We determine criteria for the twist by an Atkin–Lenher involution to have points over a local field. As a corollary we give a new proof of the theorem of Jordan and Livné on Qp points when p |D and for the first time give criteria for Qp points when p |N. We also give congruence conditions for roots modulo p of Hilbert class polynomials.
A Newly Designed Anal Fistula Plug: Clinicopathological Study in an Experimental Iatrogenic Fistula Model
Authors: Aikawa Masayasu , Miyazawa Mitsuo , Okada Katsuya , Akimoto Naoe , Koyama Isamu , Yamaguchi Shigeki , Ikada Yoshito 
Published: May 2013

Abstract
We report on a clinicopathologic study in an animal model of treatment with a new bioabsorbable polymer plug (BAPP). Over a 2-week period, 6 porcine models, which each had 4 anal fistulae, were created using Blake drains. The pigs were divided into 2 groups: the BAPP-treatment group (n = 12 fistulae) and the control group (n = 12 fistulae). Two weeks later, the pigs were humanely killed, and the perianal sites were excised and examined with gross and pathologic studies. Each fistula in the BAPP group was completely cured. In the pathologic study, the treatment sites had little disarray, few defects in the muscular layer, and small numbers of inflammatory cells. The control group had a significantly greater number of inflammatory cells and microabscesses than the BAPP group. The newly developed BAPP reduced the infection and induced good healing in anal fistulae. The BAPP may be a useful new device for the clinical treatment of anal fistulae.
Cervical Priming Before Diagnostic Operative Hysteroscopy in Infertile Women: A Randomized, Double-Blind, Controlled Comparison of 2 Vaginal Misoprostol Doses
Authors: Bastu Ercan , Celik Cem , Nehir Asli , Dogan Murat , Yuksel Bahar , Ergun Bulent 
Published: May 2013

Abstract
The aim of this study was to evaluate the efficacy of vaginal misoprostol for cervical priming at doses of 200 mcg and 400 mcg, 12 to 15 hours before diagnostic office hysteroscopy (OH) without anesthesia in patients with infertility. Sixty infertile patients requiring a diagnostic office hysteroscopy for investigation of infertility were included in the study. The patients were randomly allocated into 3 vaginally administered misoprostol groups: (1) control group, (2) 200-mcg dose group, and (3) 400-mcg dose group. Misoprostol significantly facilitated the procedure of OH: cervical entry was easier; procedural time was shorter; baseline cervical width was larger; and pain scoring was lower in the misoprostol groups compared with the control group. Increasing the dose of misoprostol from 200 mcg to 400 mcg did not improve the effect on cervical dilation. Misoprostol is a promising analog to use for cervical priming before OH. Since doses of 200 mcg and 400 mcg vaginal misoprostol 12 hours before the OH both have proven to be effective regimens, 200 mcg may be preferred. However, before routine clinical usage, further research is needed through large, randomized, controlled trials powered to detect a difference in complications to determine whether misoprostol reduces complications in OH.
Initial Management of BRAF V600E-Variant Anaplastic Thyroid Cancer
Authors: Hamidi Sarah , Dadu Ramona , Zafereo Mark E. , Ferrarotto Renata , Wang Jennifer R. , Maniakas Anastasios , Gunn G. Brandon , Lee Anna , Spiotto Michael T. , Iyer Priyanka C. , Sousa Luana G. , Akhave Neal S. , Ahmed Salmaan , Learned Kim O. , Lu Charles , Lai Stephen Y. , Williams Michelle , Hosseini S. Mohsen , Busaidy Naifa L. , Cabanillas Maria E. 
Published: July 2024

ImportanceBRAF/MEK inhibitors revolutionized the treatment of BRAF V600E-variant anaplastic thyroid carcinoma (BRAFv-ATC), offering improved outcomes for patients with this previously incurable disease.ObservationsAnaplastic thyroid carcinoma (ATC) accounts for approximately half of thyroid cancer−related deaths. It presents as a rapidly growing tumor that often invades locoregional structures and spreads to distant sites early; therefore, prompt diagnosis, staging, and treatment initiation are of the essence in the treatment of ATC. Although most oncologists will encounter a patient with ATC in their practice, the rarity of this disease makes treatment challenging, particularly because those with BRAFv-ATC no longer have a dismal prognosis. BRAF/MEK kinase inhibitors have transformed the outlook and treatment of BRAFv-ATC. Therefore, molecular profiling to identify these patients is critical. More recently, the addition of immunotherapy to BRAF/MEK inhibitors as well as the use of the neoadjuvant approach were shown to further improve survival outcomes in BRAFv-ATC. Many of these recent advances have not yet been incorporated in the currently available guidelines, allowing for disparities in the treatment of patients with BRAFv-ATC across the US. With the increasing complexity in the management of BRAFv-ATC, this Consensus Statement aims to formulate guiding recommendations from a group of experts to facilitate therapeutic decision-making.Conclusions and RelevanceThis Consensus Statement from the FAST (Facilitating Anaplastic Thyroid Cancer Specialized Treatment) group at MD Anderson Cancer Center emphasizes that rapid identification of a BRAF V600E pathogenic variant and timely initiation of sequential therapy are critical to avoid excess morbidity and mortality in patients with BRAFv-ATC. In the past decade, remarkable progress has been made in the treatment of patients with BRAFv-ATC, justifying these new evidence-based recommendations reached through a consensus of experts from a high-volume center.
Biometric‐Tuned E‐Skin Sensor with Real Fingerprints Provides Insights on Tactile Perception: Rosa Parks Had Better Surface Vibrational Sensation than Richard Nixon
Authors: Hou Senlin , Huang Qingyun , Zhang Hongyu , Chen Qingjiu , Wu Cong , Wu Mengge , Meng Chen , Yao Kuanming , Yu Xinge , Roy Vellaisamy A. L. , Daoud Walid , Wang Jianping , Li Wen Jung 
Published: July 2024

AbstractThe dense mechanoreceptors in human fingertips enable texture discrimination. Recent advances in flexible electronics have created tactile sensors that effectively replicate slowly adapting (SA) and rapidly adapting (RA) mechanoreceptors. However, the influence of dermatoglyphic structures on tactile signal transmission, such as the effect of fingerprint ridge filtering on friction‐induced vibration frequencies, remains unexplored. A novel multi‐layer flexible sensor with an artificially synthesized skin surface capable of replicating arbitrary fingerprints is developed. This sensor simultaneously detects pressure (SA response) and vibration (RA response), enabling texture recognition. Fingerprint ridge patterns from notable historical figures – Rosa Parks, Richard Nixon, Martin Luther King Jr., and Ronald Reagan – are fabricated on the sensor surface. Vibration frequency responses to assorted fabric textures are measured and compared between fingerprint replicas. Results demonstrate that fingerprint topography substantially impacts skin‐surface vibrational transmission. Specifically, Parks' fingerprint structure conveyed higher frequencies more clearly than those of Nixon, King, or Reagan. This work suggests individual fingerprint ridge morphological variation influences tactile perception and can confer adaptive advantages for fine texture discrimination. The flexible bioinspired sensor provides new insights into human vibrotactile processing by modeling fingerprint‐filtered mechanical signals at the finger‐object interface.
Occurrence of cancer in Marfan syndrome: Report of two patients with neuroblastoma and review of the literature
Authors: Maya‐González Carolina , Delgado‐Vega Angelica Maria , Taylan Fulya , Lagerstedt Robinson Kristina , Hansson Lina , Pal Niklas , Fagman Henrik , Puls Florian , Wessman Sandra , Stenman Jakob , Georgantzi Kleopatra , Fransson Susanne , Díaz De Ståhl Teresita , Ek Torben , Palmer Ruth , Tesi Bianca , Kogner Per , Martinsson Tommy , Nordgren Ann 
Published: July 2024

AbstractMarfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by pathogenic variants in FBN1, with a hitherto unknown association with cancer. Here, we present two females with MFS who developed pediatric neuroblastoma. Patient 1 presented with neonatal MFS and developed an adrenal neuroblastoma with unfavorable tumor genetics at 10 months of age. Whole genome sequencing revealed a germline de novo missense FBN1 variant (NP_000129.3:p.(Asp1322Asn)), resulting in intron 32 inclusion and exon 32 retention. Patient 2 was diagnosed with classic MFS, caused by a germline de novo frameshift variant in FBN1 (NP_000129.3:p.(Cys805Ter)). At 18 years, she developed high‐risk neuroblastoma with a somatic ALK pathogenic variant (NP_004295.2:p.(Arg1275Gln)). We identified 32 reported cases of MFS with cancer in PubMed, yet none with neuroblastoma. Among patients, we observed an early cancer onset and high frequency of MFS complications. We also queried cancer databases for somatic FBN1 variants, finding 49 alterations reported in PeCan, and variants in 2% of patients in cBioPortal. In conclusion, we report the first two patients with MFS and neuroblastoma and highlight an early age at cancer diagnosis in reported patients with MFS. Further epidemiological and functional studies are needed to clarify the growing evidence linking MFS and cancer.
Carbonate Ester‐Based Sodium Metal Battery with High‐Capacity Retention at −50 °C Enabled by Weak Solvents and Electrodeposited Anode
Authors: Hu Chao , Guo Shan , Huang Fei , Yang Yi , Yan Chong , Zhao Chen‐Zi , Liang Shuquan , Fang Guozhao , Zhang Qiang 
Published: July 2024

AbstractSodium metal batteries (SMBs) have received increasing attention due to the abundant sodium resources and high energy density, but suffered from the sluggish interfacial kinetic and unstable plating/stripping of sodium anode at low temperature, especially when matched with ester electrolytes. Here, we develop a stable ultra‐low‐temperature SMBs with high‐capacity retention at −50 °C in a weak solvated carbonate ester‐based electrolyte, combined with an electrodeposited Na (Cu/Na) anode. The Cu/Na anode with electrochemically activated “deposited sodium” and stable inorganic‐rich solid electrolyte interphase (SEI) is favor for the fast Na+ migration, therefore accelerating the interfacial kinetic process. As a result, the Cu/Na||NaCrO2 battery exhibited the highest capacity retention (compared to room‐temperature capacity) in carbonate ester‐based SMBs (98.05 % at −25 °C, 91.3 % at −40 °C, 87.9 % at −50 °C, respectively). The cyclic stability of 350 cycles at −25 °C with a high energy efficiency of 96.15 % and 70 cycles at −50 °C can be achieved. Even in chill atmospheric environment with the fluctuant temperature, the battery can still operate over one month. This work provides a new opportunity for the development of low‐temperature carbonate ester‐based SMBs.