bluuebunny/crossref_metadata_2025_split huggingface dataset:
LC‐MS/MS method for the determination of pitolisant: application to rat pharmacokinetic and brain penetration studies
Authors: Nirogi Ramakrishna , Ajjala Devender Reddy , Kandikere Vishwottam , Pantangi Hanumanth Rao , Jonnala Mahesh Reddy , Bhyrapuneni Gopinadh , Muddana Nageswar Rao , Vurimindi Himabindu 
Published: June 2013

ABSTRACTA simple and sensitive LC‐MS/MS method was developed and validated for the quantitation of pitolisant, an H3 receptor antagonist/inverse agonist. Acetonitrile protein precipitation technique was used to prepare rat blood and brain tissue homogenate samples by using aripiprazole as internal standard (IS). Chromatographic separation was performed by using Xbridge column (2.1 × 50 mm, 3.5 µm) with a gradient elution program. The mobile phase consists of ammonium formate (10 mm) with 0.2% formic acid and acetonitrile. Multiple reaction monitoring mode was used in positive polarity with a transition of m/z 296.3 → 98.2 for the pitolisant and m/z 448.2 → 285.3 for the IS. The calibration curves were linear in the range of 0.1–100 ng/mL in both the blood and brain homogenate samples. This method was applied to quantify samples obtained from the pharmacokinetic and brain penetration studies in male wistar rats. Mean maximum concentration, area under the curve from zero to infinity and half‐life of the pitolisant were found to be 3.4 ± 1.7 ng/mL, 5 ± 4 ng h/mL and 1.9 ± 0.3 h, respectively, after a 3 mg/kg oral dose. The mean calculated concentrations in the brain were found to be 38, 60 and 52 ng/g at 0.5, 1 and 2 h, respectively. Copyright © 2013 John Wiley & Sons, Ltd.
An online coupled peritoneal macrophage/cell membrane chromatography and high‐performance liquid chromatography/mass spectrometry method to screen for anti‐inflammatory components from the Chinese traditional medicine Chloranthus multistachys Pei
Authors: Li Weifeng , Xing Wei , Wang Sicen , Fan Ting , Huang Huimin , Niu Xiaofeng , He Langchong 
Published: June 2013

ABSTRACTCell membrane chromatography (CMC) is a chromatographic biological affinity method that uses specific cell membranes as the stationary phase. In this study, a novel peritoneal macrophage/cell membrane chromatography (PM/CMC)–online‐high performance liquid chromatography/mass spectrometry (HPLC/MS) method was established to screen for the anti‐inflammatory components from traditional Chinese medicines using hydrocortisone and dexamethasone as standards. The stationary phase of the CMC employed mouse peritoneal macrophage cell membranes. This method was applied to the purification and identification of components in extracts of Chloranthus multistachys Pei. The major component retained by CMC was identified as isofraxidin by HPLC/MS. In vitro experiments revealed that IF was able to inhibit the production of nitric oxide and tumor necrosis factor‐α in lipopolysaccharide‐stimulated mice and peritoneal macrophages in a dose‐dependent manner. The results demonstrated that the PM/CMC‐online‐HPLC/MS is an effective screening system for the rapid detection, enrichment, and identification of target components from complex samples. Copyright © 2013 John Wiley & Sons, Ltd.
Long‐term control of large pontine arteriovenous malformation using gamma knife therapy: a review with illustrative case
Authors: Mortazavi Martin M. , Patel Daxa , Griessenauer Christoph J. , Tubbs R. Shane , Fisher Winfield S. 
Published: June 2013

AbstractBrain stem arteriovenous malformations (AVMs) are rare and their clinical management is controversial. A location in highly eloquent areas and a greater risk of radionecrosis are both serious issues for radiosurgery of this entity. We report a case of a pontine AVM treated successfully with gamma knife therapy. At 3 years angiographic follow‐up, imaging demonstrated complete thrombosis and there were no new neurological deficits, and at 7 years clinical follow‐up, the patient continued to be neurologically stable. Although all treatments carry risk of neurological compromise, gamma knife therapy may offer the best treatment option for brain stem AVMs as seen in the case presented herein. This case illustrates a rare case of holo‐pontine AVM tolerating gamma radiation with complete angiographical response and minimal neurological sequalae.
Use of regadenoson for measurement of fractional flow reserve
Authors: Prasad Aditya , Zareh Meena , Doherty Reece , Gopal Ambarish , Vora Hita , Somma Keith , Mehra Anilkumar , Clavijo Leonardo C. , Matthews Ray V. , Shavelle David M. 
Published: June 2013

ObjectiveTo compare the use of regadenoson to adenosine for measurement of fractional flow reserve (FFR).BackgroundFFR is an accepted method to assess the functional significance of intermediate coronary artery stenoses and uses adenosine to induce maximal hyperemia. The use of the selective A2a receptor agonist regadenoson for FFR is not established.MethodsFifty‐seven patients undergoing clinically indicated FFR assessment of intermediate coronary stenoses were included. For the initial assessment of FFR, hyperemia was achieved by a standard intravenous adenosine infusion (140 mcg/kg/min). After a washout period of 10 min, FFR was reassessed using regadenoson as a single 0.4 mg intravenous bolus. FFR measurements were recorded at baseline and following maximal hyperemia with both agents.ResultsMean age was 57 ± 8 years and 47 were male. Sixty coronary lesions were evaluated and were located in the left anterior descending in 34, the left circumflex in 9, right coronary in 15, and left main coronary artery in 2. Mean ( ± SD) FFR following adenosine and regadenoson was 0.79 ( ± 0.09) and 0.79 (±0.09), respectively, P = NS. Time to FFR nadir was shorter with regadenoson compared to adenosine, 36.6 ± 24 versus 66 ± 0.19 sec, P < 0.0001, respectively. No patients experienced any significant side effects related to regadenoson.ConclusionsRegadenoson is a viable alternative to intravenous adenosine for achieving maximal hyperemia during FFR assessment. Compared to adenosine, regadenoson has a similar hemodynamic response, achieves more rapid hyperemia, is easier to use, and has an excellent side‐effect profile. © 2013 Wiley Periodicals, Inc.
Early results with the LARIAT device for left atrial appendage exclusion in patients with atrial fibrillation at high risk for stroke and anticoagulation
Authors: Stone Diana , Byrne Timothy , Pershad Ashish 
Published: June 2013

ObjectivesTo evaluate early outcomes of left atrial appendage (LAA) closure via a percutaneous LAA ligation approach with the SentreHeart LARIAT™ snare device.BackgroundAtrial fibrillation increases the risk of stroke 4–5 fold, which can have devastating outcomes. Exclusion of the LAA is believed to decrease the risk of embolic stroke.MethodsTwenty‐seven patients with atrial fibrillation, a high risk of stroke, and contraindication or intolerance for anticoagulation therapy underwent percutaneous ligation of the LAA with the LARIAT device. Initial LAA closure was confirmed with TEE and contrast fluoroscopy.ResultsThe acute procedural success was 92.6%. One patient sustained a perforation of the LAA and was treated conservatively. The patient underwent LAA closure surgically the next day. In one patient the attempt to advance the LARIAT over the LAA was unsuccessful. Patients were followed for a mean of 4 months. Preserved LAA closure was confirmed with a 45 day follow‐up TEE in 22 of 25 patients completing the procedure. Peri‐operative complications included three cases of pericarditis and one case of a periprocedural CVA due to thrombus formation on the transseptal sheath. During follow‐up, there was one stroke thought to be noncardioembolic and one pleural effusion. There were no deaths.ConclusionsThese results show that percutaneous LAA exclusion can be achieved successfully with an acceptable rate of periprocedural and short‐term complications. Further studies and longer follow‐up are needed to determine whether LAA exclusion lowers the long‐term risk of thromboembolic events in patients with AF and contraindications to anticoagulation. © 2015 Wiley Periodicals, Inc.
Porous Protein Crystals as Reaction Vessels
Authors: Ueno Takafumi 
Published: June 2013

AbstractPorous protein crystals have the potential to provide new porous materials due to their unique chemical environments composed of amino acid residues periodically exposed at the surface of the solvent channels in the crystal lattice. This enables accumulation of external compounds in special arrangements by metal coordination interactions or by chemical modifications. This article presents a review of advances in the recently established field of porous protein crystals.
Biomimetic Synthesis of Materials for Technology
Authors: Galloway Johanna M. , Bramble Jonathan P. , Staniland Sarah S. 
Published: June 2013

AbstractIn a world with ever decreasing natural reserves, researchers are striving to find sustainable methods of producing components for technology. Bioinspired, biokleptic and biomimetic materials can be used to form a wide range of technologically relevant materials under environmentally friendly conditions. Here we investigate a range of biotemplated and bioinspired materials that can be used to develop components for devices, such as optics, photonics, photovoltaics, circuits and data storage.
ChemInform Abstract: Hydrothermal Synthesis and Structural and Spectroscopic Properties of the New Triclinic Form of GdBO3:Eu3+ Nanocrystals.
Authors: Szczeszak Agata , Grzyb Tomasz , Barszcz Boleslaw , Nagirnyi Vitali , Kotlov Aleksei , Lis Stefan 
Published: June 2013

AbstractTriclinic Gd1‐xEuxBO3 (0 ≤ x ≤ 0.1) nanophosphors are prepared by hydrothermal reaction of a stoichiometric mixture of Gd(OAc)3 and Eu(OAc)3 together with 25% excess H3BO3 and H2O (autoclave, 180 °C, 5 h).
ChemInform Abstract: BaFe9LiO15: A New Layered Antiferromagnetic Ferrite.
Authors: Yang Tao , Daoud‐Aladine Aziz , Thomas Michael F. , Claridge John B. , Rosseinsky Matthew J. 
Published: June 2013

AbstractBaFe9LiO15 is prepared by solid state reaction of a stoichiometric mixture of BaCO3, Fe2O3, and Li2CO3 (1.
ChemInform Abstract: Interlayer Switching of Reduction in Layered Oxide, Bi4V2O11‐δ (0 ≤ δ ≤ 1).
Authors: Zhang Yaoqing , Ueda Yutaka 
Published: June 2013

AbstractPolycrystalline Bi4V2O11‐δ samples are prepared by solid state reaction of a stoichiometric mixture of Bi2O3, V2O3, and V2O5 (sealed quartz tube, 600 °C, 3 d).
ChemInform Abstract: Cobalt Polyoxometalates as Heterogeneous Water Oxidation Catalysts.
Authors: Soriano‐Lopez Joaquin , Goberna‐Ferron Sara , Vigara Laura , Carbo Jorge J. , Poblet Josep M. , Galan‐Mascaros Jose Ramon 
Published: June 2013

AbstractA polyoxometalate‐modified amorphous carbon electrode is prepared by blending water insoluble Cs15K [Co9(H2O)6(OH)3 (HPO4)2(PW9O34)3] ·41H2O with carbon paste.
ChemInform Abstract: Sol‐Gel Synthesis and Photocatalytic Study of Visible Light Active N‐Doped KSbWO6.
Authors: Reddy J. R. , Ravi G. , Veldurthi Naveen Kumar , Velchuri Radha , Pola Someshwar , Vithal Muga , Sreedhar B. 
Published: June 2013

AbstractKSbWO6 is prepared by a sol—gel method starting with an aqueous mixture of antimony potassium tartrate, tungsten powder, H2O2, citric acid, and ethylene glycol at 100 °C for 2—3 h followed by heating at 700 °C for 8 h.
ChemInform Abstract: Efficient and Productive Asymmetric Michael Addition: Development of a Highly Enantioselective Quinidine‐Based Organocatalyst for Homogeneous Recycling via Nanofiltration.
Authors: Siew Weiming Eugene , Ates Celal , Merschaert Alain , Livingston Andrew G. 
Published: June 2013

AbstractA series of enlarged quinidine‐derived organocatalysts are synthesized based on the concept of polyalkylation.
ChemInform Abstract: Photoreduction of Aliphatic and Aromatic Thioketals: New Access to the Reduction of Carbonyl Groups by a Desulfurization Chain Process.
Authors: Oksdath‐Mansilla Gabriela , Argueello Juan E. , Penenory Alicia B. 
Published: June 2013

AbstractThe photoinduced reduction of dithianes and related compounds to the corresponding hydrocarbons uses 1,4‐cyclohexadiene as the hydrogen source in the presence of KOtBu.
ChemInform Abstract: Pyridine Group Assisted Addition of Diazo‐Compounds to Imines in the 3‐CC Reaction of 2‐Aminopyridines, Aldehydes, and Diazo‐Compounds.
Authors: Gulevich Anton V. , Helan Victoria , Wink Donald J. , Gevorgyan Vladimir 
Published: June 2013

AbstractA novel three‐component coupling reaction of 2‐aminoazines, aromatic aldehydes, and diazo compounds producing β‐amino‐α‐diazoesters is developed.
ChemInform Abstract: Practical One‐Pot Conversion of Aryl Bromides and β‐Bromostyrenes into Aromatic Nitriles and Cinnamonitriles.
Authors: Ishii Genki , Harigae Ryo , Moriyama Katsuhiko , Togo Hideo 
Published: June 2013

AbstractThis environmentally benign one‐pot method avoids toxic metal cyanides or rare metals to prepare aromatic nitriles from aryl halides via formation of Grignard reagents and their dimethylformamide or N‐formylpiperidine adducts.
ChemInform Abstract: Ruthenium‐Catalyzed Direct Arylation of C—H Bonds in Aromatic Amides Containing a Bidentate Directing Group: Significant Electronic Effects on Arylation.
Authors: Aihara Yoshinori , Chatani Naoto 
Published: June 2013

AbstractThe title reaction proceeds selectively at the less hindered C—H bonds of meta‐substituted aromatic amides (I).
ChemInform Abstract: One‐Pot Rhodium‐Catalyzed, Base‐ and Solvent‐Free Synthesis of 2‐(Bromomethyl)furan Derivatives and Synthesis of Hashmi Phenol Through Platinum‐Catalyzed Cascade Cyclization.
Authors: Sivaraman Mahalingam , Muralidharan Doraiswamy , Perumal Paramasivan T. 
Published: June 2013

AbstractDicarbonyl iodonium ylides, generated in situ, react with propargyl bromide to produce furan derivatives (III).
ChemInform Abstract: Highly Diastereoselective Synthesis of 3‐Indolylglycines via an Asymmetric Oxidative Heterocoupling Reaction of a Chiral Nickel(II) Complex and Indoles.
Authors: Lin Daizong , Wang Jiang , Zhang Xu , Zhou Shengbin , Lian Jie , Jiang Hualiang , Liu Hong 
Published: June 2013

AbstractThe chiral auxiliary (I) can be recovered in nearly quantitative yield.
ChemInform Abstract: A Simple and Efficient Microwave‐Assisted Synthesis of Substituted Isoindolinone Derivatives via Ligand‐Free Pd‐Catalyzed Domino C—C/C—N Coupling Reaction.
Authors: Tyagi Vikas , Khan Shahnawaz , Chauhan Prem M. S. 
Published: June 2013

AbstractThe reaction of various aromatic amides with isocyanides (II) and (VII) affords isoindolinone derivatives in moderate to good yield and high stereoselectivity.
ChemInform Abstract: Gold(I)‐Catalyzed Rearrangement of N‐Aryl 2‐Alkynylazetidines to Pyrrolo[1,2‐a]indoles.
Authors: Kern Nicolas , Hoffmann Marie , Blanc Aurelien , Weibel Jean‐Marc , Pale Patrick 
Published: June 2013

AbstractA new and efficient Au‐catalyzed rearrangement reaction is reported to synthesize the title compounds in high yields.
ChemInform Abstract: Synthesis and Biological Evaluation of Some Pyrazoline Derivatives Bearing a Dithiocarbamate Moiety as New Cholinesterase Inhibitors.
Authors: Altintop Mehlika D. , Oezdemir Ahmet , Kaplancikli Zafer A. , Turan‐Zitouni Guelhan , Temel Halide E. , Ciftci Guelsen A. 
Published: June 2013

Abstract30 Title compounds of type (III), and (V) are prepared and evaluated for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase.
ChemInform Abstract: A Simple and Straightforward Method for One‐Pot Synthesis of 2,4,5‐Triarylimidazoles Using Titanium Dioxide as an Eco‐Friendly and Recyclable Catalyst under Solvent‐Free Conditions.
Authors: Brahmachari Goutam , Das Suvankar 
Published: June 2013

AbstractAn efficient synthesis of the title compounds (III) (13 examples) by three‐component one‐pot condensation of 1,2‐diketones, aryl aldehydes, and ammonium acetate using titanium dioxide as mild and effective catalyst is presented.
ChemInform Abstract: Enantioselective Synthesis of 1,2,4‐Triazolines by Chiral Iron(II)‐Complex Catalyzed Cyclization of α‐Isocyano Esters and Azodicarboxylates.
Authors: Wang Min , Liu Xiaohua , He Peng , Lin Lili , Feng Xiaoming 
Published: June 2013

AbstractSubsequent selective protection group modifications can be accomplished without relevant racemization.
ChemInform Abstract: Palladium‐Catalyzed and KOtBu‐Promoted Caryl—Oalcoholic Coupling: An Efficient One‐Pot Synthesis of Oxygen‐Containing Fused Rings.
Authors: Ahmed Atiur , Dhara Shubhendu , Ray Jayanta K. 
Published: June 2013

AbstractA convenient approach to benzochromene derivatives is achieved via hydride reduction of aldehydes (III) and subsequent intramolecular Pd‐catalyzed cyclization of the resulting alcohols.
ChemInform Abstract: Synthesis, Characterization and Anthelmintic Activity of 3‐(4‐Acetyl‐5‐phenyl‐4,5‐dihydro‐1,3,4‐oxadiazol‐2‐yl)‐2H‐chromen‐2‐one Derivatives.
Authors: Sudha B. Naga , Sridhar C. , Sastry V. Girija , Reddy Y. S. R. , Sreevidya Owk , Lavanya S. , Jyothi V. Asha , Nagesh V. , Sen Saikat , Chakraborty Raja 
Published: June 2013

AbstractAll the title compounds (VIII) show remarkable in vitro anthelmintic activity.
ChemInform Abstract: Facile Synthesis of 3‐Arylpyridine Derivatives by Palladacycle‐Catalyzed Stille Cross‐Coupling Reaction.
Authors: Ma Gaizhi , Leng Yuting , Wu Yusheng , Wu Yangjie 
Published: June 2013

AbstractCyclopalladated ferrocenylimines catalyze the Stille cross‐coupling reaction of aryl halides with alkylstannylpyridines, enabling the synthesis of arylpyridines in moderate to excellent yields.
ChemInform Abstract: Synthesis, Molecular Modeling and Biological Evaluation of 2‐Aminomethyl‐5‐(quinolin‐2‐yl)‐1,3,4‐oxadiazole‐2(3H)‐thione Quinolone Derivatives as Novel Anticancer Agent.
Authors: Sun Juan , Zhu Hui , Yang Zhong‐Ming , Zhu Hai‐Liang 
Published: June 2013

AbstractMost of the synthesized compounds, especially derivatives (IIIc) and (IIId), exhibit substantial broad‐spectrum antitumor activities.
ChemInform Abstract: A General and Facile Synthesis of Novel Polysubstituted Quinazolin‐4‐(3H)‐ones
Authors: Xin Minhang , Gao Ying , Xiang Hua , Chen Dong , He Yi , You Qidong 
Published: June 2013

Abstractinvolving a Fe‐mediated reduction and acid‐catalyzed cyclization of o‐nitrobenzamides (III) as the key step
ChemInform Abstract: Peculiarities of Cyclization of Ethyl 2‐Ethoxymethylene‐3‐oxo‐3‐(polyfluoroalkyl)propionates with 3‐Amino‐5‐hydroxypyrazole.
Authors: Goryaeva Marina V. , Burgart Yanina V. , Saloutin Viktor I. 
Published: June 2013

AbstractThe title reaction leads to dihydropyrazolopyrimidines (III), which suffer an unprecedented recyclization into pyrazolo[3,4‐b]pyridines (IV) in refluxing EtOH.
ChemInform Abstract: Application of a Recyclable Fluorous Oxime in the Convenient Synthesis of 3‐Amino‐1,2‐benzisoxazoles and 4‐Amino‐1H‐2,3‐benzoxazines.
Authors: Ang Wei Jie , Chu Chi‐Yuan , Chou Tzyy‐Chao , Lo Lee‐Chiang , Lam Yulin 
Published: June 2013

AbstractThe strategy comprises linking the respective benzonitrile (I) or (III) to a fluorous oxime tag to give an aryloxime intermediate which then undergoes cyclization with cleavage of the substrate‐tag to provide title compounds (II) and (IV), respectively.
ChemInform Abstract: Synthesis of Pinacol Arylboronates from Aromatic Amines: A Metal‐Free Transformation.
Authors: Qiu Di , Jin Liang , Zheng Zhitong , Meng He , Mo Fanyang , Wang Xi , Zhang Yan , Wang Jianbo 
Published: June 2013

AbstractWith optimized reaction conditions the substrates scope is significantly expanded to various aniline derivatives, esp.
Self‐concordance for empirical likelihood
Authors: Owen Art B. 
Published: June 2013

AbstractAbstractThe usual approach to computing empirical likelihood for the mean uses Newton's method after eliminating a Lagrange multiplier and replacing the function by a quadratic Taylor approximation to the left of . This paper replaces the quadratic approximation by a quartic. The result is a self‐concordant function for which Newton's method with backtracking has theoretical convergence guarantees. The Canadian Journal of Statistics 41: 387–397; 2013 © 2013 Statistical Society of Canada
Social environment, secondary smoking exposure, and smoking cessation among head and neck cancer patients
Authors: Kashigar Aidin , Habbous Steven , Eng Lawson , Irish Brendan , Bissada Eric , Irish Jonathan , Brown Dale , Gilbert Ralph , Gullane Patrick , Xu Wei , Huang Shao‐Hui , Witterick Ian , Freeman Jeremy , O'Sullivan Brian , Waldron John , Liu Geoffrey , Goldstein David 
Published: June 2013

BACKGROUNDSmoking during treatment of squamous cell head and neck cancer (HNC) has adverse affects on toxicity, treatment, and survival. The purpose of this report was to evaluate sociodemographic predictors of smoking cessation in HNC patients to support the development of a smoking cessation program.METHODSNewly diagnosed HNC patients (2007‐2010) at Princess Margaret Cancer Centre treated with curative intent were prospectively recruited. Patients completed self‐reported baseline and follow‐up questionnaires, assessing changes in social habits. Predictors of smoking cessation and time to quitting were evaluated using logistic regression and Cox proportional hazard models, respectively.RESULTSOf 295 HNC patients, 49% were current smokers at diagnosis, and 50% quit after diagnosis. These individuals were more likely to have smoked for fewer years (P = .0003), never used other forms of tobacco (P = .0003), and consumed less alcohol (P = .002). No cigarette exposure at home (OR, 7.44 [3.04‐18.2]), no spousal smoking (OR, 4.25 [1.70‐10.6]), and having fewer friends who smoke (OR, 2.32 [1.00‐5.37]) were consistent predictors of smoking cessation after diagnosis. Having none of these exposures (OR, 13.8 [4.13‐46.0]) and seeing a family physician (OR, 3.92 [1.38‐11.2]) were independently associated with smoking cessation and time‐to‐quitting analyses. Most HNC patients (68%) quit within 6 months of diagnosis. Patients who were ex‐smokers at diagnosis were older (P < .0001), more likely to be female (P = .0002), more likely to be married (P = .0004), more educated (P = .01), and had fewer pack‐years of smoking (P < .0001).CONCLUSIONSSpousal smoking, peer smoking, smoke exposure at home, and seeing a family physician were strongly and consistently associated with smoking cessation and time to quitting after a HNC diagnosis. Cancer 2013;119:2701–2709. © 2013 American Cancer Society.