bluuebunny/crossref_metadata_2025_split huggingface dataset:
Callous–Unemotional Traits and Response to Functional Family Therapy in Adolescent Offenders
Authors: White Stuart F. , Frick Paul J. , Lawing Kathryn , Bauer Daliah 
Published: November 2012

OBJECTIVEThe current study examined whether callous–unemotional (CU) traits moderated the effectiveness of Functional Family Therapy for juvenile justice involved adolescents.METHODParticipants were all youths (n = 134) who had been arrested and participated in an FFT program provided in a community mental health center over a 20‐month period (mean age 15.34, 71.6% males, 59% African‐American). Parent and self‐report ratings of emotional, behavioral, and social functioning, multi‐informant ratings of treatment progress, and probation/arrest records were used as outcome indicators.RESULTSCU traits were associated with poorer behavioral, emotional, and social adjustment prior to treatment but they were also associated with greater improvements in adjustment over the course of treatment. CU traits were not associated with significantly lower rates of participation or higher rates of treatment dropout, and the association between CU traits and risk for violent charges decreased after treatment at 6‐ and 12‐month follow‐ups. However, CU traits were still correlated with poorer levels of adjustment post‐treatment, less perceived change over treatment by youth and their parents, and increased likelihood of violent offending during treatment.CONCLUSIONSThe results of this study indicate that FFT can lead to improvements in youth with CU traits; however, they enter treatment with a greater number of symptoms and are at higher risk for committing violence during treatment than other youth. Copyright © 2012 John Wiley & Sons, Ltd.
Progenitor cells from cartilage—No osteoarthritis‐grade‐specific differences in stem cell marker expression
Authors: Bernstein Peter , Sperling Ines , Corbeil Denis , Hempel Ute , Fickert Stefan 
Published: November 2012

AbstractTissue engineering efforts for the fabrication of cartilage substitutes head toward applicability in osteoarthritis (OA). Progenitor cells can be harvested from the osteoarthritic joint itself, resembling multipotent mesenchymal stromal cells (MSC). Our objective was to analyze MSC characteristics of those cells in respect to the OA‐related damage of their harvest site. OA cartilage was obtained from six patients during alloarthroplastic knee surgery, sample grading was done according to Outerbridge's classification. Upon enzymatic dissociation, primary chondrocytes were expanded in two‐dimensional monolayer culture. At distinct cell passages, the process of dedifferentiation was phenotypically monitored; cell surface expression of classical MSC markers was analyzed by flow cytometry. Cells were subjected to chondrogenesis and osteogenesis after their fourth passage. At third passage, 95% of cells became positive for cluster of differentiation (CD)105 and further subclassification revealed that the majority of them were positive for both CD73 and CD90. CD105+CD73+CD90+ phenotype meets thus the minimal surface antigen criteria for MSC definition. More than one‐third of dedifferentiated chondrocytes displayed a coexpression of CD9+CD166+CD90+ and to a lesser extent CD105+CD73+CD44+, irrespective of the stage of the original cartilage degradation. Finally, we could successfully demonstrate a redifferentiation of these progenitors into sulfated glycosaminoglycan producing cells. The basic level of alkaline phosphatase activity could not be enhanced upon osteogenic differentiation. In conclusion, chondrogenic progenitors derived from OA cartilages with low or high Outerbridge's grade can be seen as a potential cellular source for cartilage replacement. © 2012 American Institute of Chemical Engineers Biotechnol. Prog., 2013
Anatomy and physiology of the clitoris, vestibular bulbs, and labia minora with a review of the female orgasm and the prevention of female sexual dysfunction
Authors: Puppo Vincenzo 
Published: November 2012

AbstractThis review, with 21 figures and 1 video, aims to clarify some important aspects of the anatomy and physiology of the female erectile organs (triggers of orgasm), which are important for the prevention of female sexual dysfunction. The clitoris is the homologue of the male's glans and corpora cavernosa, and erection is reached in three phases: latent, turgid, and rigid. The vestibular bulbs cause “vaginal” orgasmic contractions, through the rhythmic contraction of the bulbocavernosus muscles. Because of the engorgement with blood during sexual arousal, the labia minora become turgid, doubling or tripling in thickness. The corpus spongiosum of the female urethra becomes congested during sexual arousal; therefore, male erection equals erection of the female erectile organs. The correct anatomical term to describe the erectile tissues responsible for female orgasm is the female penis. Vaginal orgasm and the G‐spot do not exist. These claims are found in numerous articles that have been written by Addiego F, Whipple B, Jannini E, Buisson O, O'Connell H, Brody S, Ostrzenski A, and others, have no scientific basis. Orgasm is an intense sensation of pleasure achieved by stimulation of erogenous zones. Women do not have a refractory period after each orgasm and can, therefore, experience multiple orgasms. Clitoral sexual response and the female orgasm are not affected by aging. Sexologists should define having sex/love making when orgasm occurs for both partners with or without vaginal intercourse. Clin. Anat. 26:134–152, 2013. © 2012 Wiley Periodicals, Inc.
Using imaging‐based, three‐dimensional models of the cervix and uterus for studies of cervical changes during pregnancy
Authors: House Michael , McCabe Reid , Socrate Simona 
Published: November 2012

AbstractPreterm birth affects over 12% of all pregnancies in the United States for an annual healthcare cost of $26 billion. Preterm birth is a multifactorial disorder but cervical abnormalities are a prominent feature in many patients. Women with a short cervix are known to be at increased risk for preterm birth and a short cervix is used to target therapy to prevent preterm birth. Although the clinical significance of a short cervix is well known, the three‐dimensional anatomical changes that lead to cervical shortening are poorly understood. Here, we review our previous studies of the three‐dimensional anatomy of the cervix and uterus during pregnancy. The rationale for these studies was to improve our understanding of the deformation mechanisms leading to cervical shortening. Both magnetic resonance imaging and three‐dimensional (3D) ultrasound were used to obtain anatomical data in healthy, pregnant volunteers. Solid models were constructed from the 3D imaging data. These solid models were used to create numerical models suitable for biomechanical simulation. Three simulations were studied: cervical funneling, uterine growth, and fundal pressure. These simulations showed that cervical changes are a complex function of the tissue properties of the cervical stroma, the loading conditions associated with pregnancy and the 3D anatomical geometry of the cervix and surrounding structures. An improved understanding of these cervical changes could point to new approaches to prevent undesired cervical shortening. This new insight should lead to therapeutic strategies to delay or prevent preterm birth. Clin. Anat. 26:97–104, 2013. © 2012 Wiley Periodicals, Inc.
Diffusion tensor imaging and fiber tractography for the visualization of the female pelvic floor
Authors: Zijta Frank M. , Froeling Martijn , Nederveen Aart J. , Stoker Jaap 
Published: November 2012

AbstractIn the past decade, the evaluation of the pelvic support for understanding pelvic floor dysfunction by means of magnetic resonance imaging (MRI) has been an emerging area of research. Both static and dynamic MRI techniques have been effectively applied as a diagnostic resource to reveal abnormalities to the muscular pelvic support, but fail to unravel the precise pathophysiology of this complex disorder. Diffusion tensor imaging (DTI) and tractography comprise enhanced MRI techniques that enable the three‐dimensional visualization of anisotropic tissue, such as muscle fibers, and provide a quantitative description of tissue organization and integrity. Quantifying DTI and fiber tractography might be able to reveal microstructural abnormalities in the pelvic support that are not noticeable using conventional MRI techniques. In this article, we discuss relevant anatomy, the current state of DTI and tractography in the evaluation of the female pelvic floor, and their potential future clinical applications. Clin. Anat. 26:110–114, 2013. © 2012 Wiley Periodicals, Inc.
Nipple‐sparing mastectomy in modern breast practice
Authors: Murthy Vijayashree , Chamberlain Ronald S. 
Published: November 2012

AbstractBreast cancer management has evolved from the conventional radical Halsted to a fully integrated multidisciplinary approach. Nipple sparing mastectomy (NSM) is an innovative technique that preserves native breast envelope without mutilation of nipple‐areola complex (NAC), thus providing a reasonable alternative for early cancers without NAC involvement and prophylactic high risk patients and avoids multiple surgical procedures required for reconstruction. This article aims to critically review indications, intra‐operative protocols, radiotherapy planning and limitations of NSM. Patient selection should be based on study of breast duct anatomy by Magnetic Resonance Imaging, mammographic tumor‐nipple distance and obligatory intra‐operative frozen section from retro‐areolar tissue. Tumor size, axillary lymph node status, lymphovascular invasion and/or degree of intraductal component are factors used to include NSM candidates based on institutional practice. Given the heterogeneity of patients and lack of standardization of preoperative investigations, surgical technique and pathologic sampling of retro‐areola tissue so far, mandates a multi‐institutional prospective study to define and validate a role for NSM in invasive breast cancer and DCIS. Nipple necrosis is an important NSM complication which can be greatly reduced using alternative skin incisions. Even if the nipple survives, an insensate nipple and lack of sexual function is common and requires preoperative counseling and discussion. Finally the relation and timing of intra‐operative versus adjuvant breast radiation and tailoring of dosage and delivery methods has not been fully explored. Although NSM reduces psychological trauma associated with nipple loss, the oncologic safety as well as functional and aesthetic outcomes needs additional investigation. Clin. Anat. 26:56–65, 2013. © 2012 Wiley Periodicals, Inc.
The Discovery of New Cyanobactins from Cyanothece PCC 7425 Defines a New Signature for Processing of Patellamides
Authors: Houssen Wael E. , Koehnke Jesko , Zollman David , Vendome Jeremie , Raab Andrea , Smith Margaret C. M. , Naismith James H. , Jaspars Marcel 
Published: November 2012

AbstractCyanobactins, including patellamides, are a group of cyanobacterial post‐translationally modified ribosomal cyclic peptides. The final product should in theory be predictable from the sequence of the precursor peptide and the associated tailoring enzymes. Understanding the mechanism and recognition requirements of these enzymes will allow their rational engineering. We have identified three new cyanobactins from a Cyanothece PCC 7425 culture subjected to a heat shock. One of these compounds revealed a novel signature signal for ThcA, the subtilisin‐like serine protease that is homologous to the patellamide protease PatA. The crystal structure of the latter and modelling studies allow rationalisation of the recognition determinants for both enzymes, consistent with the ribosomal biosynthetic origin of the new compounds.
Clinical outcomes in real‐world patients with acute myocardial infarction receiving XIENCE V® everolimus‐eluting stents
Authors: Sudhir Krishnankutty , Hermiller James B. , Naidu Srihari S. , Henry Timothy D. , Mao Vivian W. , Zhao Weiying , Ferguson Joanne M. , Wang Jin , Jonnavithula Lalitha , Simonton Charles A. , Rutledge David R. , Krucoff Mitchell W. ,   on behalf of the XIENCE V USA Investigators
Published: November 2012

ObjectivesThe objective of this analysis was to evaluate the safety and effectiveness of XIENCE V in acute myocardial infarction (AMI).BackgroundThe XIENCE V® Everolimus‐eluting coronary stent was superior to the TAXUS® paclitaxel‐eluting stent in angiographic and clinical outcomes in the SPIRIT II, III, and IV randomized controlled trials, but patients with AMI were excluded.MethodsXIENCE V USA is a large, prospective, multicenter, real‐world single‐arm postmarket surveillance trial. Consecutive patients undergoing PCI with XIENCE V were enrolled. For this analysis, clinical outcomes in 673 patients presenting with AMI (STEMI, n = 125) were as compared to patients without AMI (n = 3528) at 1 year.ResultsAt 1 year, ARC‐defined stent thrombosis (ST) rates were 1.08% in AMI vs. 0.85% in the non‐AMI group (P = 0.4987). The late ST (30 days‐1 year) rates were 0.31% vs. 0.47% (AMI vs. non‐AMI, P = 0.7551). Rates of target lesion revascularization (TLR) were 4.1% vs. 4.6% (P = 0.6104), and rates of target lesion failure (TLF) were 9.1% vs. 8.5%, (P = 0.5964). With the historical WHO definition of MI, 1 year TLF rates were 7.0% vs. 6.7% (P = 0.8001). Improvements in quality of life, angina frequency, angina stability, and physical limitations occurred at 6 months (each P < 0.0001) and were sustained at 1 year in both groups. There were no significant differences in clinical outcomes between STEMI and non‐STEMI patients.ConclusionsAt 1 year, AMI patients treated with XIENCE V had low rates of ST, TLR, and TLF, similar to non‐AMI patients. Marked improvements in patients' health status in this subgroup were also demonstrated. © 2012 Wiley Periodicals, Inc.
Closure of tubular patent ductus arteriosus in infants with the amplatzer vascular plug II
Authors: Gross Abby AR , Donnelly Jon P 
Published: November 2012

ObjectivesWe used the Amplatzer Vascular Plug II to close tubular patent ductus arteriosus (DA) in infants.BackgroundDespite advancements in device design, catheter‐based therapy for the DA of tubular morphology has been problematic. Likewise, the currently available devices are not designed to close DAs in small, often premature infants as the size of the delivery systems can be prohibitive and the devices obstructive to aortic or pulmonary artery flow.MethodsWe report our experience using the second‐generation Amplatzer Vascular Plug (AVP II) in 10 patients with sizeable, tubular DAs, seven of whom were less than or equal to 4.0 kg.ResultsComplete closure was attained in all patients, with one minor complication. In four small infants, the device was delivered without arterial access under echocardiographic guidance.ConclusionIt is our belief that the AVP II device can be a useful embolization device for DAs in this difficult patient population. © 2012 Wiley Periodicals, Inc.
[RhIII(dmbpy)2Cl2]+ as a Highly Efficient Catalyst for Visible‐Light‐Driven Hydrogen Production in Pure Water: Comparison with Other Rhodium Catalysts
Authors: Stoll Thibaut , Gennari Marcello , Serrano Isabel , Fortage Jérôme , Chauvin Jérôme , Odobel Fabrice , Rebarz Mateusz , Poizat Olivier , Sliwa Michel , Deronzier Alain , Collomb Marie‐Noëlle 
Published: November 2012

AbstractWe report a very efficient homogeneous system for the visible‐light‐driven hydrogen production in pure aqueous solution at room temperature. This comprises [RhIII(dmbpy)2Cl2]Cl (1) as catalyst, [Ru(bpy)3]Cl2 (PS1) as photosensitizer, and ascorbate as sacrificial electron donor. Comparative studies in aqueous solutions also performed with other known rhodium catalysts, or with an iridium photosensitizer, show that 1) the PS1/1/ascorbate/ascorbic acid system is by far the most active rhodium‐based homogeneous photocatalytic system for hydrogen production in a purely aqueous medium when compared to the previously reported rhodium catalysts, Na3[RhI(dpm)3Cl] and [RhIII(bpy)Cp*(H2O)]SO4 and 2) the system is less efficient when [IrIII(ppy)2(bpy)]Cl (PS2) is used as photosensitizer. Because catalyst 1 is the most efficient rhodium‐based H2‐evolving catalyst in water, the performance limits of this complex were further investigated by varying the PS1/1 ratio at pH 4.0. Under optimal conditions, the system gives up to 1010 turnovers versus the catalyst with an initial turnover frequency as high as 857 TON h−1. Nanosecond transient absorption spectroscopy measurements show that the initial step of the photocatalytic H2‐evolution mechanism is a reductive quenching of the PS1 excited state by ascorbate, leading to the reduced form of PS1, which is then able to reduce [RhIII(dmbpy)2Cl2]+ to [RhI(dmbpy)2]+. This reduced species can react with protons to yield the hydride [RhIII(H)(dmbpy)2(H2O)]2+, which is the key intermediate for the H2 production.
Cooperative Supramolecular Polymerization: Comparison of Different Models Applied on the Self‐Assembly of Bis(merocyanine) Dyes
Authors: Fernández Gustavo , Stolte Matthias , Stepanenko Vladimir , Würthner Frank 
Published: November 2012

AbstractThree new molecular building blocks 1 a–c for supramolecular polymerization are described that feature two dipolar merocyanine dyes tethered by p‐xylylene spacers. Concentration‐ and temperature‐dependent UV/Vis spectroscopy in chloroform combined with dynamic light scattering, capillary viscosimetry and atomic force microscopy investigations were applied to elucidate the mechanistic features of the self‐assembly of these strongly dipolar dyes. Our detailed studies reveal that the self‐assembly is very pronounced for bis(merocyanines) 1 a,b bearing linear alkyl chains, but completely absent for bis(merocyanine) 1 c bearing sterically more bulky ethylhexyl substituents. Both temperature‐ and concentration‐dependent UV/Vis data provide unambiguous evidence for a cooperative self‐assembly process for bis(merocyanines) 1 a,b, which was analyzed in detail by the Meijer–Schenning–Van‐der‐Schoot model (applicable to temperature‐dependent data) and by the Goldstein–Stryer model (applicable to concentration‐dependent data). By combining both methods all parameters of interest to understand the self‐assembly process could be derived, including in particular the nucleus size (8–10 monomeric units), the cooperativity factor (ca. 0.006), and the nucleation and elongation constants of about 103 and 106 M−1 in chloroform at room temperature, respectively.
Investigation and Comparison of the Mechanistic Steps in the [(Cp*MCl2)2] (Cp*=C5Me5; M=Rh, Ir)‐Catalyzed Oxidative Annulation of Isoquinolones with Alkynes
Authors: Wang Nuancheng , Li Bin , Song Haibin , Xu Shansheng , Wang Baiquan 
Published: November 2012

AbstractThe mechanism of the [(Cp*MCl2)2] (M=Rh, Ir)‐catalyzed oxidative annulation reaction of isoquinolones with alkynes was investigated in detail. In the first acetate‐assisted CH‐activation process (cyclometalated step) and the subsequent mono‐alkyne insertion into the MC bonds of the cyclometalated compounds, both Rh and Ir complexes participated well. However, the desired final products, dibenzo[a,g]quinolizin‐8‐one derivatives, were only formed in high yield when the Rh species participated in the final oxidative coupling of the CN bond. Moreover, a RhI sandwich intermediate was isolated during this transformation. The iridium complexes were found to be inactive in the oxidative coupling processes. All of the relevant intermediates were fully characterized and determined by single‐crystal X‐ray diffraction analysis. Based on this mechanistic study, a RhIII→RhI→RhIII catalytic cycle was proposed for this reaction.
Increase of Protein Yield in High Five Cells in a Single‐Use Perfusion Bioreactor by Medium Replacement
Authors: Rausch Mareike , Pörtner Ralf , Knäblein Jörg 
Published: November 2012

AbstractA multitude of heterologous proteins is needed in pharmaceutical research. These have to be produced in robust and flexible cultivation systems to allow a fast and cost‐effective handling. Moreover, these systems should be scalable and meet quality and regulatory requirements. The baculovirus expression vector system propagated on High Five insect cells is a popular choice for this purpose. For this expression system an efficient, robust and scalable process was developed based on a single‐use technology and a medium replacement strategy with cell retention. It is shown that a medium replacement in the Wave bioreactor is feasible and can be scaled up to a 10‐L scale without much effort.
Impacts of International Greenfield Investment on Firm Valuation
Authors: Chang Shao‐Chi , Chang Juei‐Chi 
Published: November 2012

AbstractOur study examines the announcement effects of 343 international greenfield investments by 289 U.S. firms for their impact on shareholder wealth. This paper develops five hypotheses based on the positive‐multinational‐network hypothesis. The evidence indicates that market reactions to announcements by firms entering developing countries are more favorable than those entering developed countries. In addition, the results show that the wealth effect for firms entering a host country for the first time is greater than for those that are already operating within the country. As for the long run, greenfield firms have shown improvement in their operating performance and stock performance. Copyright © 2012 ASAC. Published by John Wiley & Sons, Ltd.
Impact of Network Position and Knowledge Diversity on Knowledge Creation: The Empirical Setting of Research Communities
Authors: Chen Chia‐Shen , Liu Chih‐Hsing 
Published: November 2012

AbstractWe examined the role of network position and knowledge diversity as related to new knowledge creation within a network of 239 academics from business administration departments at four universities. Analyses of their 1,827 publications involving 1,541 coauthors between 1986 and 2008 revealed an inverse U‐shaped relationship between network centrality and knowledge creation. Moreover, knowledge diversity positively moderated the association between centrality and the quality of the knowledge created, but negatively moderated the centrality‐knowledge quantity relationship. Copyright © 2012 ASAC. Published by John Wiley & Sons, Ltd.
A Quality Assessment of Cardiac Auscultation Material on YouTube
Authors: Camm Christian F. , Sunderland Nicholas , Camm A. John 
Published: November 2012

AbstractBackground:YouTube is a highly utilized Web site that contains a large amount of medical educational material. Although some studies have assessed the education material contained on the Web site, little analysis of cardiology content has been made. This study aimed to assess the quality of videos relating to heart sounds and murmurs contained on YouTube.Hypothesis:We hypothesized that the quality of video files purporting to provide education on heart auscultation would be highly variable.Methods:Videos were searched for using the terms “heart sounds,” “heart murmur,” and “heart auscultation.” A built‐in educational filter was employed, and manual rejection of non‐English language and nonrelated videos was undertaken. Remaining videos were analyzed for content, and suitable videos were scored using a purpose‐built tool.Results:YouTube search located 3350 videos in total, and of these, 22 were considered suitable for scoring. The average score was 4.07 out of 7 (standard deviation, 1.35). Six videos scored 5.5 or greater and 5 videos scoring 2.5 or less. There was no correlation between video score and YouTube indices of preference (hits, likes, dislikes, or search page). The quality of videos found in this study was highly variable. YouTube indications of preference were of no value in determining the value of video content. Therefore, teaching institutions or professional societies should endeavor to identify and highlight good online teaching resources.Conclusions:YouTube contains many videos relating to cardiac auscultation, but very few are valuable education resources.The authors have no funding, financial relationships, or conflicts of interest to disclose. 1