bluuebunny/crossref_metadata_2025_split huggingface dataset:
Value of foetal umbilical vein standardised blood flow volume in predicting weight gain in the third trimester: a prospective case-cohort study
Authors: Fang Qian , Shi Yihao , Zhang Chao , Cai Ying , Yuan Cuili , Yang Jiaxiang , He Guannan 
Published: July 2024

ObjectiveThis study aims to establish a prediction model of foetal umbilical vein standardised blood flow volume (sQuv) on estimated foetal weight (EFW) in the third trimester.MethodsA case-cohort study involving 200 eligible normal foetuses was conducted at the Ultrasound Department of Longquanyi District of Maternity and Child Healthcare Hospital between June 1, 2020 and December 31, 2021. Ultrasound measurements were taken at two separate intervals to assess EFW and the rate of EFW (rEFW) [first: between 28 w and 33 w6d of gestational age (GA); second: after 4–6 weeks]. Umbilical vein blood flow volume (Quv) and sQuv (normalised with EFW) were calculated only during the initial measurement. Using general linear regression, a prediction model for EFW based on GA and sQuv was developed, with the gestational week employed as a calibration scalar and validated using linear regression cross-validation.ResultsIn the third trimester, EFW exhibited significant correlations with GA, abdominal circumference (AC), head circumference (HC) and Quv (all ρ &gt; 0.6, P &lt; 0.001). Furthermore, the rEFW showed significant correlations with Quv and sQuv (all ρ &gt; 0.6, P &lt; 0.001). A linear regression equation was established using a general linear regression model: rEFW = 0.32689 × sQuv. Additionally, a foetal weight prediction model (EFW = −2,554.6770 + 0.9655 × sQuv + 129.6916 × GA) was established using sQuv. The above two formulas were cross-validated by intra-group linear regression and proved to be of good efficacy.ConclusionsIn the third trimester, EFW displayed significant correlations with GA, AC, HC and Quv. Additionally, the rEFW exhibited significant correlations with Quv and sQuv. The sQuv during the third trimester has predictive value for foetal weight, serving as an early warning indicator.
Validity of self-assessment pubertal Tanner stages by realistic color images and Pubertal Development Scale in a longitudinal cohort study
Authors: Luo Jie , Wu Di , Tian Yu , Wang Yujie , Zhang Qin , He Zongwei , Wang Hong , Liu Qin 
Published: July 2024

IntroductionTo date, the reliability of pubertal development self-assessment tools is questioned, and very few studies have explored the comparison between these tools in longitudinal studies. Hence, this study aimed to examine the reliability of pubertal development self-assessment using realistic color images (RCIs) and the Pubertal Development Scale (PDS) in a longitudinal cohort study.MethodsOur longitudinal study recruited 1,429 participants (695 boys and 734 girls), aged 5.8–12.2 years old, in Chongqing, China. We conducted two surveys, 6 months apart. Tanner stages were examined by trained medical students at each visit. RCIs and PDS scores were used to self-assess puberty at each visit. Agreement between physical examination and self-assessment was determined using weighted kappa (wk), accuracy, and Kendall rank correlation.ResultsThe concordance of puberty self-assessment using RCIs at baseline and the first follow-up was almost perfect in girls and boys, wk &gt;0.800 (p &lt; 0.001). At baseline, the concordance of genital development self-assessment using RCIs was fair in boys, wk = 0.285 (p &lt; 0.001), and that of boys’ pubic hair development self-assessment using RCIs was poor, wk = 0.311 [95% confidence interval (CI) −0.157 to 0.818]. The wk of the PDS was less than 0.300, except for breast development. The reliability and validity of the PDS in this study population were low, and the consistency of the PDS was not good.ConclusionsThe concordance of RCIs is better than that of the PDS. Pubertal development self-assessment using RCIs is reliable, while the reliability and validity of the PDS are unacceptable. Therefore, RCIs are recommended as a reliable pubertal development self-assessment tool to measure pubertal development for large-scale epidemiological investigations and long-term longitudinal studies in China.
Neonatal abstinence syndrome and infant mortality and morbidity: a population-based study
Authors: Lisonkova Sarka , Wen Qi , Richter Lindsay L. , Ting Joseph Y. , Lyons Janet , Mitchell-Foster Sheona , Oviedo-Joekes Eugenia , Muraca Giulia M. , Bayrampour Hamideh , Cattoni Eric , Abrahams Ronald 
Published: July 2024

BackgroundInfant health among newborns with neonatal abstinence syndrome (NAS) has been understudied. We examined infant mortality and hospitalizations among infants diagnosed with NAS after birth.MethodsAll live births in British Columbia (BC), Canada, for fiscal years from 2004–2005 to 2019–2020, were included (N = 696,900). NAS was identified based on International Classification of Diseases, version 10, Canadian modification (ICD-10-CA) codes; the outcomes included infant death and hospitalizations during the first year of life, ascertained from BC linked administrative data. Generalized estimating equation models were used to adjust for maternal factors.ResultsThere were 2,439 infants with NAS (3.50 per 1,000 live births). Unadjusted for other factors, infant mortality was 2.5-fold higher in infants with vs. without NAS (7.79 vs. 3.08 per 1,000 live births, respectively) due to increased post-discharge mortality NAS (5.76 vs. 1.34 per 1,000 surviving infants, respectively). These differences diminished after adjustment: adjusted odds ratio (AOR) for infant death was 0.85 [95% confidence interval (CI): 0.52–1.39]; AOR for post-discharge death was 1.75 (95% CI 1.00–3.06). Overall, 22.3% infants with NAS had at least one hospitalization after post-neonatal discharge, this proportion was 10.7% in those without NAS. During the study period, discharge to foster care declined from 49.5% to 20.3% in infants with NAS.ConclusionUnadjusted for other factors, infants with NAS had increased post-discharge infant mortality and hospitalizations during the first year of life. This association diminished after adjustment for adverse maternal and socio-medical conditions. Infants with NAS had a disproportionately higher rate of placement in foster care after birth, although this proportion declined dramatically between 2004/2005 and 2019/2020. These results highlight the importance of implementing integrated care services to support infants born with NAS and their mothers during the first year of life and beyond, even though NAS itself is not independently associated with increased infant mortality.
Post-traumatic stress disorder and associated factors among high school students who experienced war in Woldia town
Authors: Kassa Mulat Awoke , Fenta Sefineh , Anbesaw Tamrat , Tesfa Natnael Amare , Zemariam Alemu Birara , Kassaw Genanew Mulugeta , Abate Biruk Beletew , Semagn Elsabet Gezmu 
Published: July 2024

BackgroundThe experience of war in recent time is very common around the world, and the impact is profound on the mental health of the victims, especially among the young population. The most implicated mental health problem is post-traumatic stress disorder, which comes after an exposure to trauma as a severe and long-term result of the traumatic event. Studies in developed countries revealed this finding, but there is insufficient information in developing countries, where much of war and conflict exist and young population live including Ethiopia. Therefore, this study aims to assess the prevalence and associated factors of post-traumatic stress disorder among high school students who experienced war.ObjectiveWe assessed the prevalence and factors associated with post-traumatic stress disorder among high school students who experienced war.MethodsA multi-centered school base cross-sectional study was conducted from May 23 to June 08, 2022. Data were collected from high school students in Woldia town. Bivariable and multivariable logistic regression was used to identify the independent factors associated with post-traumatic stress disorder.ResultsA total of 338 of the 410 students participated in this study (94.5% response rate). The prevalence of post-traumatic stress disorder was 39.2%. In the multivariable analysis, poor social support (AOR = 3.40, 95% CI: 1.45, 7.95), depression (AOR = 3.24, 95% CI: 1.69,6.21), high level of perceived stress (AOR = 2.98, 95% CI: 1.61, 5.50), being in war fighting situation (AOR = 2.85, 95% CI: 1.40, 5.78), and witnessing the murder of family members or friends (AOR = 3.05, 95% CI: 1.47, 6.32) were factors significantly associated with post-traumatic stress disorder at a p-value &lt;0.05.Conclusions and recommendationsIn this study, around two in five of high school students had post-traumatic stress disorder. Independent factors of PTSD were depression, high stress levels, poor social support, witnessing the murder of family members/friends, and being in war fighting situation. We recommend that the Ministry of Education and the Ministry of Health collaborate to integrate mental health services into schools. This focuses on the early detection of students at risk of PTSD, such as those with depression, high perceived stress levels, and exposure to murder or war, and provides necessary social support to prevent PTSD.
Adverse childhood experiences and cognitive function in later life: the sequential mediating roles of education level and adult loneliness
Authors: Deng Xiaojuan , Xie Min , Wang Yu , Cai Jia , Zou Min , Wang Qiang 
Published: July 2024

BackgroundThis study assesses the impact of adverse childhood experiences (ACEs) on the cognitive function of older adults. Furthermore, it examines the potential underlying mechanism involving education level and the subjective “feeling of loneliness” (FOL).MethodsAnalyzing a population-based cohort sample from the China Health and Retirement Longitudinal Study database, 8,365 subjects aged 45 or older were interviewed in 2018. Ten ACEs indicators were measured using life history questionnaires assessed at 2014. FOL was assessed using a single item from 10-item Center for Epidemiological Studies Depression Scale (CESD-10). Cognitive function was assessed using a structured questionnaire comprising four dimensions: memory, orientation, computation, and visuospatial abilities.ResultsIn the fully adjusted model, which accounted for age, gender, marital status, smoke, drink, rural residence, and education levels of both mothers and fathers, the linear regression analysis indicated that ACEs were inversely associated the lower education level (B = −0.058, 95% CI = −0.090, −0.026, p &lt; 0.001), and ACEs were found to be linked to an elevated risk of FOL (B = 0.072, 95% CI = 0.056, 0.089, p &lt; 0.001). In addition, ACEs was not significantly associated with cognitive function (B = −0.047, 95% CI = −0.108, 0.015, p = 0.136), but FOL was significantly associated with cognitive function (B = −0.483, 95% CI = −0.561, −0.404, p &lt; 0.001). Mediation analysis revealed that education level and FOL sequentially and partially mediated the association between ACEs and the total cognitive score, with a proportion mediated of 52.58%.LimitationsThe evaluation of ACEs exposure was based on binary response options. This method limited our ability to explore various dimensions of adversity, such as ages of occurrence, severity, frequency, duration, and the extent of psychological effects at the time. Furthermore, the assessment of loneliness relied on a single item from the CESD-10, introducing a potential source of measurement error.ConclusionOur study unveils a substantial association between ACEs and education level, as well as with FOL and cognitive function in the older adults. Moreover, education level and FOL serve as sequential mediating factors in the relationship between ACEs and cognitive function.
Multi-scale dynamics by adjusting the leaking rate to enhance the performance of deep echo state networks
Authors: Inoue Shuichi , Nobukawa Sou , Nishimura Haruhiko , Watanabe Eiji , Isokawa Teijiro 
Published: July 2024

IntroductionThe deep echo state network (Deep-ESN) architecture, which comprises a multi-layered reservoir layer, exhibits superior performance compared to conventional echo state networks (ESNs) owing to the divergent layer-specific time-scale responses in the Deep-ESN. Although researchers have attempted to use experimental trial-and-error grid searches and Bayesian optimization methods to adjust the hyperparameters, suitable guidelines for setting hyperparameters to adjust the time scale of the dynamics in each layer from the perspective of dynamical characteristics have not been established. In this context, we hypothesized that evaluating the dependence of the multi-time-scale dynamical response on the leaking rate as a typical hyperparameter of the time scale in each neuron would help to achieve a guideline for optimizing the hyperparameters of the Deep-ESN.MethodFirst, we set several leaking rates for each layer of the Deep-ESN and performed multi-scale entropy (MSCE) analysis to analyze the impact of the leaking rate on the dynamics in each layer. Second, we performed layer-by-layer cross-correlation analysis between adjacent layers to elucidate the structural mechanisms to enhance the performance.ResultsAs a result, an optimum task-specific leaking rate value for producing layer-specific multi-time-scale responses and a queue structure with layer-to-layer signal transmission delays for retaining past applied input enhance the Deep-ESN prediction performance.DiscussionThese findings can help to establish ideal design guidelines for setting the hyperparameters of Deep-ESNs.
The Study of Combination of Biodegradable Packaging and Biocoating with Lactic Acid Bacteria as a Green Alternative for Traditional Packaging in Gouda Cheese
Authors: Aleksandrovas Elvidas , Vasiliauskaitė Agnė , Milerienė Justina , Muizniece-Brasava Sandra , Ciprovica Inga , Songisepp Epp , Rud Ida , Axelsson Lars , Kasparavičienė Beatričė , Lutter Liis , Malakauskas Mindaugas , Šernienė Loreta 
Published: July 2024

Biodegradable packaging, both alone and in combination with acid whey protein coatings, has been used to pack fresh Gouda cheese to improve preservation prior ripening or storage. This study involved three key components: (i) the selection of biodegradable packaging (BP), (ii) the development of a plain liquid acid whey protein concentrate, pectin-based edible coating (BP + Ch + Coating), and (iii) the incorporation of at least 6 log10 CFU (colony forming units) mL−1 Lacticaseibacillus paracasei (BP + Ch + Coating + Lp) and Lactobacillus helveticus (BP + Ch + Coating + Lh) strains. The created compositions were compared with cheese packed in conventional polyethylene (PE) packaging to evaluate their overall synergy effect in reducing microbiological spoilage and influencing chemical parameters in Gouda cheese during 45 days of ripening and cold storage. The evaluation included microbiological analysis (total LAB, Enterobacteriaceae spp., and fungi CFU) and quality assessment of pH, moisture content, water activity, texture, and colour (CEI system) during ripening and shelf life. Although biodegradable packaging (BP) alone did not protect the cheese effectively compared to conventional packaging (EVA/PE/EPC/PVDC), the combination of biodegradable packaging with a coating (BP + Ch + Coating) showed protective properties against Enterobacteriaceae spp. and mould, maintaining moisture, pH, and colour during ripening and storage. Incorporation of L. helveticus (BP + Ch + Coating + Lh) into the coating efficiently decreased the growth of fungi.
Hyperpolarized Water for Coronary Artery Angiography and Whole-Heart Myocardial Perfusion Quantification
Authors: Zhao Yupeng , Lerche Mathilde Hauge , Karlsson Magnus , Olin Rie Beck , Hansen Esben Søvsø Szocska , Aastrup Malene , Redda Mohsen , Laustsen Christoffer , Hanson Lars G. , Ardenkjær-Larsen Jan Henrik 
Published: July 2024

Purpose: Water freely diffuses across cell membranes, making it suitable for measuring absolute tissue perfusion. In this study, we introduce an imaging method for conducting coronary artery angiography and quantifying myocardial perfusion across the entire heart using hyperpolarized water. Methods: 1H was hyperpolarized using dissolution dynamic nuclear polarization (dDNP) with UV-generated radicals. Submillimeter resolution coronary artery images were acquired as 2D projections using a spoiled GRE (SPGRE) sequence gated on diastole. Dynamic perfusion images were obtained with a multi-slice SPGRE with diastole gating, covering the entire heart. Perfusion values were analyzed through histograms, and the most frequent estimated perfusion value (the mode of the distribution), was compared with the average values for 15O water PET from the literature. Results: A liquid state polarization of 10% at the time of the injection and a 30 s T1 in D2O TRIS buffer were measured. Both coronary artery and dynamic perfusion images exhibited good quality. The main and small coronary artery branches were well resolved. The most frequent estimated perfusion value is around 0.6 mL/g/min, which is lower than the average values obtained from the literature for 15O-water PET (around 1.1 and 1.5 mL/g/min). Conclusions: The study successfully demonstrated the feasibility of achieving high-resolution, motion-free coronary artery angiography and 3D whole-heart quantitative myocardial perfusion using hyperpolarized water.
Recompensa del médico: análisis del acróstico "Ser médico: ¡cuidar del dolor humano!", de Alberto Araújo
Authors: Dias Rafaella Oliveira , Lima Maria Fernanda Araujo Barbosa , Oliveira Carolina da Mata , Souza Laryssa Ramos Pino de , Carvalho Luiza Novaes , Albernaz Maria Carolina Jorge , Leite Geovana Lavínia dos Santos , Marques Barbara Mendes , Briere Ana Luiza , Cardoso Emanuel Guimarães , Aires Leticia Saldanha Camargos 
Published: July 2024

INTRODUCCIÓN: Medicina y literatura son formas distintas de arte. Así, frecuentemente los médicos sienten la necesidad de expresarse más allá de la literatura científica y transmitir sus experiencias a través de obras profundas que exploran los aspectos de la vida, trascendiendo técnica y concreto. Alberto Araujo, médico y autor de "Ser médico: cuidar del dolor humano", transmite esta visión de humanidad, empatía y recompensa de ser médico. METODOLOGIA: Se realizaron búsquedas en bases de datos "LILACS" y "SCIELO". Se analizaron los aspectos multidimensionales del sentimiento de recompensa y reconocimiento entre profesionales a luz de la literatura de autoría médica. Seleccionaron 14 artículos considerados apropiados para el tema: interacción médico-paciente, centrándose en las recompensas más allá de los aspectos financieros. RESULTADOS: Medicina va más allá de los límites de ciencia; también abarca la complejidad de relaciones interpersonales y mente humana. Los médicos deben ser conscientes de la importancia de su papel como agentes de transformación en diversas circunstancias, reemplazando el dolor con alivio y la limitación con rehabilitación. CONCLUSIÓN: El principio bioético de autonomía permite que el paciente ocupe un lugar central en su atención médica. Araujo destaca la esencia de la medicina al abarcar todos los aspectos e individualidades del paciente, apuntando prevenir en lugar de curar. Relación médico-paciente es crucial para mentalidad y pronóstico del paciente, haciendo humanización y empatía deberes del médico. Para el médico, la recompensa es reconocimiento del paciente por su esfuerzo y sacrificio, sabiendo que hicieron todo posible por "salvar vidas preciosas cuando pudieron".
ANALISIS KUALITAS PELAYANAN PASIEN RAWAT JALAN DI PUSKESMAS KUTAWARINGIN KABUPATEN BANDUNG
Authors: Fikri Sapardan Muhamad , Hadithya Riyan 
Published: July 2024

Kualitas pelayanan Puskesmas adalah hal yang penting untuk diwujudkan, demi tercapainya suatu kepuasan yang akan dirasakan oleh pasien. Penelitian ini dilakukan di Puskesmas Kutawaringin yaitu kepada pasien yang pernah atau sedang di rawat jalan dengan tujuan untuk mengetahui kualitas pelayanan rawat jalan di Puskesmas Kutawaringin. Desain penelitian ini menggunakan jenis penelitian kualitatif dan pendekatan deskriptif. Sampel penelitian merupakan 120 pasien yang pernah mendapatkan pelayanan kesehatan di Puskesmas Kutawaringin. Pengambilan data dilakukan dengan pengisian kuesioner, observasi dan studi kepustakaan. Hasil penelitian menunjukkan bahwa dari 120 pasien yang pernah berobat ke Puskesmas Kutawaringin skor 11.638 dengan nilai rata-rata 4,03, maka dapat dikatakan bahwa kualitas pelayanan di Puskesmas Kutawaringin Kabupaten Bandung secara umum dapat dikatakan baik dan berkualitas dengan masuk kategori 5 yaitu sangat tinggi (4,21-5,00). Kualitas pelayanan pasien rawat jalan di Puskesmas Kutawaringin dikatakan baik dan berkualitas tinggi.
Pelatihan Pembuatan Beras Cerdas Omega 3 pada Kelompok Tani Budidaya di Desa Sumbersih Kecamatan Panggungrejo Kabupaten Blitar
Authors: Prayudhi Luhur Aditya , Zamrodah Yuhanin 
Published: July 2024

Kelompok tani “Budi Daya” merupakan kelompok tani di Desa Sumbersih, Kabupaten Blitar. Kelompok tani ini memiliki luas wilayah garapan kelompok tani ini yang meliputi 31 ha sawah, 41 ha tegal/baon dan pekarangan/kebun 6 ha (SK Pengukuhan Kelompok Tani, 2009). Kelompok tani ini memilih menanam umbi, jagung, padi, palawija, dan tebu sebagai komoditas utamanya. Potensi panen ubi setiap kali panen menghasilkan sekitar 50 ton dengan kisaran harga Rp. 1.000,- sampai dengan Rp. 1.500,-/ Kg nya. Akan tetapi, kurang optimalnya budi daya dan pengolahan lahan mengakibatkan pendapatan petani kurang maksimal. Selain itu adanya gizi buruk dan stunting menjadi isu nasional dan daerah, Pada tahun 2021 kasus stunting di Kabupaten Blitar mencapai 14,5%. Lalu pada tahun 2022, kasus stunting di Kabupaten Blitar turun menjadi 14,3 %. (Dinkes Kabupaten Blitar, 2022). Permasalahan yang muncul pada mitra adalah produksi, manajemen usaha. Mitra kelompok tani memiliki perencanaan yang kurang maksimal dalam manajemen usaha kelompok tani dan diversifikasi usaha tani. Selain permasalahan diatas juga adanya gizi buruk dan stunting diwilayah Kabupaten Blitar. Sedangkan permasalahan bidang ekonomi didapatkan bahwa wilayah Desa Sumbersih,Kec Panggungrejo tingkat pendapatan ekonominya sebesar Rp.20.000 / hari tiap orangnya.Sehingga tingkat pendapatan masyarakat disana tergolong rendah (Profil Desa Sumbersih, 2017). Pembuatan beras cerdas omega 3 menggunakan teknologi ekstrusi panas dilakukan pada suhu proses antara 70 C sampai 110 C dengan menggunakan cetakan (dye) yang dirancang khusus akan dapat dihasilkan produk beras cerdas yang memiliki bentuk butiran menyerupai beras. Formulasi (penimbangan bahan-bahan yang diperlukan; tepung jagung 50%, tepung mocaf 25%, tepung woretel 5 % dan tepung kacang sacha inchi 10 % GMS (Gliserol Mono Stearat) 0,5%, susu skim 0,17%, minyak nabati 3%, karagenan 2% dan air air 30% dari total berat bahan.