bluuebunny/crossref_metadata_2025_split huggingface dataset:
Free radical-scavenging activity of sequential leaf extracts of Embothrium coccineum
Authors: Leyton Miguel , Mellado Marco , Jara Carlo , Montenegro Iván , González Sebastian , Madrid Alejandro 
Published: May 2015

Abstract
The aim of this study was to evaluate the
influence of phenolic, flavonoid, and anthraquinones
from sequential extracts (n-hexane, dichloromethane,
ethyl acetate, and ethanol) of Embothrium coccineum
leaves on the antioxidant capacity, cell viability, and
toxicity of the same, in order to find possible sources
for novel antioxidants for food and pharmaceutical
formulations. Antioxidant potential of sequential extracts
was analyzed by five different assays: 2,2-diphenyl-1-
picrylhydrazyl radical scavenging activity assay (DPPH),
hydrogen peroxide scavenging activity (H2O2), oxygen
radical absorbance capacity (ORAC), ferric reducing
antioxidant power (FRAP), and total reactive antioxidant
potential (TRAP). An in vitro growth inhibition assay was
performed using sulphorhodamine dye to quantify cell
viability, while an in vivo brine shrimp lethality test was
used to quantify toxicity. The dichloromethane extract has
a greater efficiency in scavenging free radicals, combined
with low toxicity, and no effect exhibited on healthy cells,
compared to observations for the other extracts tested.
Further research is in progress to identify and separate the
active compounds of active extracts and investigate the
protective effect of extracts on human dermal fibroblast
injury induced by hydrogen peroxide.
High fat diet-induced estrus cycle disruption: effects of Ficus asperifolia
Authors: Ngadjui Esther , Nkeng-Efouet Pepin Alango , Nguelefack Telesphore Benoit , Kamanyi Albert , Watcho Pierre 
Published: May 2015

Abstract:: Obesity was reached by feeding female rats with a HFD for 10 weeks. Vaginal smear was observed daily for 3 weeks after animals were obese. Then, 70 animals with abnormal estrus cyclicity were selected and partitioned into two sets of 35 animals. Each set was further divided into seven groups of five rats. These obese rats with disrupted estrus cyclicity were orally administered the aqueous and methanolic extracts (100 and 500 mg/kg), distilled water (10 mL/kg), 5% Tween 80 (10 mL/kg) or lutenyl (0.8 µg/kg) once a day for 1 week (set I) or 4 weeks (set II). Estrus cyclicity, body weight gain, hematocrit, lipid profile, ovarian, uterine and hepatic growth indices were determined at the end of each treatment.: HFD increased the body weight of the animals by 27% and disrupted the estrus cyclicity by 98.44%. Aqueous extract (100 mg/kg) of: Our data support the anecdotal claims of
Fractional killing arises from cell‐to‐cell variability in overcoming a caspase activity threshold
Authors: Roux Jérémie , Hafner Marc , Bandara Samuel , Sims Joshua J , Hudson Hannah , Chai Diana , Sorger Peter K 
Published: May 2015

AbstractWhen cells are exposed to death ligands such as TRAIL, a fraction undergoes apoptosis and a fraction survives; if surviving cells are re‐exposed to TRAIL, fractional killing is once again observed. Therapeutic antibodies directed against TRAIL receptors also cause fractional killing, even at saturating concentrations, limiting their effectiveness. Fractional killing arises from cell‐to‐cell fluctuations in protein levels (extrinsic noise), but how this results in a clean bifurcation between life and death remains unclear. In this paper, we identify a threshold in the rate and timing of initiator caspase activation that distinguishes cells that live from those that die; by mapping this threshold, we can predict fractional killing of cells exposed to natural and synthetic agonists alone or in combination with sensitizing drugs such as bortezomib. A phenomenological model of the threshold also quantifies the contributions of two resistance genes (c‐FLIP and Bcl‐2), providing new insight into the control of cell fate by opposing pro‐death and pro‐survival proteins and suggesting new criteria for evaluating the efficacy of therapeutic TRAIL receptor agonists.
ESTUDIO DEMOGRÁFICO DE Emilia sonchifolia (ASTERACEAE) EN UNA FINCA CAFETERA DE ARMENIA, QUINDÍO, COLOMBIA
Authors: Duarte Gandica Irene , Chaib de Mares Maryam , Luna David Andrés , Aguirre-Obando Oscar Alexander , Méndez Parra Rosa María 
Published: May 2015

<p>Se realizó un estudio con el fin de determinar la estructura demográfica de <em>Emilia sonchifolia </em>(L.) DC<em> </em>en una finca cafetera del Municipio de Armenia, Quindío, Colombia, donde se recolectaron datos durante 4 semanas, en tres sitios: exterior, borde e interior del cultivo. Usando parámetros calculados a partir de los datos de campo, se construyó un modelo logístico para describir el comportamiento poblacional en el tiempo. Se encontraron diferencias significativas en las variables: número de individuos por estado etario en el tiempo, porcentaje de mortalidad, tiempo de cambio del estado plántula a juvenil y de juvenil a adulto, número de hojas y de ramas; no se encontraron diferencias significativas en la densidad poblacional, número de inflorescencias e infrutescencias en los sitios de estudio. En general, se puede atribuir este comportamiento a la estrategia de reproducción <em>r</em> que sigue <em>E. sonchifolia</em>. Finalmente, las simulaciones hechas a partir del modelo logístico sugieren que la especie tiende a desaparecer si alguno de los estados etarios no está presente inicialmente; así, una alternativa plausible para el control sería su eliminación en el estado juvenil. Los resultados ofrecen alternativas con respecto al manejo de<em> </em>poblaciones de arvenses.</p><p><strong>ABSTRACT</strong></p><p>A research study was conducted to determine the demographic structure of <em>Emilia sonchifolia</em> L. in a coffee plantation in Armenia, Quindío, Colombia. Data were collected over a period of four weeks on three sites: inside, at the border and outside a coffee farm. A logistic population model was built to describe the population behavior of <em>E. sonchifol</em><em>ia </em>over time. Statiscally significant differences were found between: number of individuals per life stage in time, mortality rate, transition time from seedling to juvenile and from juvenile to adult; and number of leaves and branches. There was no evidence for statistically significant differences in population density or in number of inflorescences and fruits between study sites. In general, the observed behavior may be attributed to the <em>r</em> strategy used by this species. Finally, our results suggest the survival of the species is conditioned by the presence of all life stages at the beginning of each simulation based on the logistic model; so, a potential strategy for its controlling would require the removal during the juvenile stage. The considerations offer alternatives regarding weed population management. </p>
Modificación de los criterios de Sgarbossa para el diagnostico de infarto agudo de miocardio en presencia de bloqueo de rama izquierda
Authors: Moreno ruiz Nelson Leandro 
Published: May 2015

El bloqueo de rama izquierda dificulta el diagnostico de infarto agudo de miocardio. Los criterios de Sgarbossa, mencionados en las guías de manejo de las diferentes sociedades científicas, son útiles pero con limitaciones bien reconocidas. Recientemente se ha publicado una modificación a estos criterios que puede mejorar su rendimiento diagnostico y así ser parte de un algoritmo de manejo de estos pacientes, aunque hasta el momento hagan falta estudios para validar lo anteriori
EDITORIAL
Authors: Leite José Yvan Pereira 
Published: May 2015

Este volume é publicado no início de maio, em meio a uma paralização pela redução da jornada de trabalho no Instituto Federal do Rio Grande do Norte. Neste contexto de aprendizado, em que o Periódico deve pensar para além do presente, a editoria encontra uma janela para, de forma permanente, disponibilizar esta edição para a comunidade.O esforço para ampliar a presença do Periódico no país e no exterior é apresentado através das figuras 1 e 2, que mostram as origens dos artigos por região e por estado, que ora publicamos. Figuras disponíveis no arquivo em pdf. Observa-se nas figuras acima que os artigos estão disseminados em doze estados brasileiros e um na França, destacando-se a região nordeste, que concentra 50% dos artigos e os estados do Rio Grande do Norte e do Rio Grande do Sul, respectivamente com 31% e 22% da origem dos artigos publicados.Este segundo volume disponibiliza vinte e quatro artigos, sendo dez na área de engenharias, oito na área de educação, três na área de administração, um na área de saúde pública, um na área de zootecnia e um na área de cultura. É importante destacar que esses artigos foram produzidos por vinte instituições, entre elas, institutos federais, empresa de pesquisa, universidades federais, estaduais, católicas, privadas e uma universidade francesa. Essa diversidade demostra o caráter plural da origem autoral, fator de sustentabilidade científica para o periódico e que representam forte relação interdisciplinar.Informo à comunidade e ao mesmo tempo desejo as boas-vindas à professora María Dolores Sánchez-Fernández da Universidade da Coruña (Espanha) que passa a integrar o conselho editorial e terá a missão de ampliar a visibilidade da HOLOS em solo ibérico.Nestes tempos de turbulência político-econômica, a escolha pela integralidade da publicação online em 2004 e a migração para plataforma de software livre são elementos sustentáveis para a perenidade e visibilidade em escala global.Enfim, convido-os a visitarem o sumário deste segundo volume e desejo que tenham uma excelente leitura! Natal, 08 de maio de 2015Prof. José Yvan Pereira Leite
A case of tooth autotransplantation after long-term cryopreservation using a programmed freezer with a magnetic field
Authors: Kaku Masato , Shimasue Hiroshi , Ohtani Junji , Kojima Shunichi , Sumi Hiromi , Shikata Hanaka , Kojima Shotoku , Motokawa Masahide , Abonti Tahsin Raquib , Kawata Toshitsugu , Tanne Kazuo , Tanimoto Kotaro 
Published: May 2015

ABSTRACT
This case report describes the treatment of a skeletal Class III malocclusion with autotransplantation of a cryopreserved tooth. To gain an esthetic facial profile and good occlusion, extraction of bimaxillary premolars and surgical therapy were chosen. The patient had chronic apical periodontitis on the lower left first molar. Although she did not feel any pain in that region, the tooth was considered to have a poor prognosis. Therefore, we cryopreserved the extracted premolars to prepare for autotransplantation in the lower first molar area because the tooth would probably need to be removed in the future. The teeth were frozen by a programmed freezer with a magnetic field (CAS freezer) that was developed for tissue cryopreservation and were cryopreserved in −150°C deep freezer. After 1.5 years of presurgical orthodontic treatment, bilateral sagittal split ramus osteotomy was performed for mandible setback. Improvement of the facial profile and the occlusion were achieved in the retention phase. Six years after the initial visit, the patient had pain on the lower left first molar, and discharge of pus was observed, so we extracted the lower left first molar and autotransplanted the cryopreserved premolar. Three years later, healthy periodontium was observed at the autotransplanted tooth. This case report suggests that long-term cryopreservation of teeth by a CAS freezer is useful for later autotransplantation, and this can be a viable technique to replace missing teeth.
Romanian Species of Lucanids (Coleoptera: Scarabaeoidea: Lucanidae) in the Collections of “Grigore Antipa” National Museum of Natural History
Authors: Stan Melania 
Published: May 2015

Abstract
The seven species of stag beetles of the Romanian fauna are present in the coleopteran collection of the Museum: Aesalus scarabaeoides scarabaeoides (Panzer), Ceruchus chrysomelinus (Hochenwarth), Sinodendron cylindricum (Linnaeus), Lucanus cervus cervus (Linnaeus), Platycerus caraboides caraboides (Linnaeus), Platycerus caprea (De Geer) and Dorcus parallelipipedus (Linnaeus). Information on the collecting data and distribution maps are given for each species. We present the male and female habitus for the two species of Platycerus.
Pourquoi le silence des femmes ? Violence sexuelle et lien de couple
Authors: Grihom Marie-José 
Published: May 2015

Les violences sexuelles peuvent durer des années dans un couple avant que la femme victime n’en parle. Comment comprendre ce silence ? Une analyse critique de deux discours courants est faite à partir de la clinique analytique individuelle et de couple. Les éléments essentiels sont alors situés dans le lien intersubjectif du couple. Sont étudiés les effets de réel de la violence sur la parole et ceux de la honte que le clinicien peut saisir au moyen du transfert pour en favoriser la nomination. Constats et hypothèses cliniques sur l’amour ou la passion de ces femmes, leur masochisme et leur besoin de punition permettent d’aborder d’autres motifs de silence. Dans la dynamique du lien, le rôle des pulsions de mort chez la victime apparaît central. La violence subie masque une violence interne liée à un sentiment d’existence menacé dans le lien à la mère, à des traumas de l’enfance, à la honte et à un défaut d’investissement narcissique.
L’automation intellectuelle, la mort de l’emploi et le revenu de pollinisation
Authors: Moulier-Boutang Yann 
Published: May 2015

Les discours lénifiants promettant de résoudre tous les problèmes sociaux et écologiques par une « reprise de la croissance », synonyme de « retour au plein emploi », sonnent de plus en plus creux. Nous vivons une deuxième vague de déploiement du capitalisme cognitif, caractérisée par l’automatisation de tâches intellectuelles bien plus complexes, dont les études les plus sérieuses montrent qu’elle annonce une explosion spectaculaire des chiffres du chômage (jusqu’au sein des classes les mieux éduquées). Les leçons de la première vague d’industrialisation du début du XIX e siècle enseignent que seuls des combats idéologiques et politiques peuvent conduire les logiques économiques à s’adapter à ces nouvelles dynamiques. Les mesures préconisées depuis 15 ans par Multitudes (revenu universel garanti, taxe pollen, réforme de l’éducation) sont plus urgentes que jamais.
Les robots oscillent entre vivant et inerte
Authors: Grimaud Emmanuel 
Published: May 2015

Il est impossible d’ouvrir un dossier consacré à la robotique sans rencontrer de multiples prophéties annonçant dans un futur proche que nous vivrons entourés de robots anthropomorphes ou zoomorphes et que nous nous machinerons par des voies que nous ne pouvons pour le moment qu’entrevoir. Peut-on envisager une approche de la robotique un peu moins prophétique et donc décevante, un peu plus pragmatique et donc plus surprenante, un peu plus réflexive et donc habitée par un principe de précaution ? Faut-il continuer à faire passer les machines pour autre chose que ce qu’elles sont ou doit-on arrêter de les prendre pour ce qu’elles ne sont pas (des animaux, des humains) ? Faut-il considérer qu’elles constituent un « règne » à part entière, à côté du minéral et du végétal, ou bien faut-il continuer de les reléguer dans l’instrumental, ce grand bazar ? Ce « manifeste » reprend quelques-unes des observations faites par ceux qui, dans le champ de l’anthropologie principalement, observent la « révolution robotique », suivent ses essais d’expérimentation/implémentation et abordent la diversité des interactions homme-machine avec les outils de l’enquête de terrain.
Le mal : Dieu responsable et innocent
Authors: Salamolard Michel 
Published: May 2015

L’année même de son décès, le regretté Adolphe Gesché publiait le premier ouvrage d’une nouvelle série intitulée « Pensées pour penser ». Comme dans sa célèbre série antérieure « Dieu pour penser », l’auteur commence par affronter le mystère du mal. Il invite à « circuler plus libre » dans ses réflexions. Le présent article se veut un hommage critique à Gesché, honorant ainsi son vœu de « reconstruire soi-même ce que l’on cherche à penser ». Trois questions sont abordées : 1. Le mal peut-il être l’objet d’explication ? 2. Dieu a-t-il été surpris par l’idée du mal ? 3. Comment comprendre aujourd’hui la doctrine du péché originel ?
Bundled Payments in Orthopedic Surgery
Authors: Bushnell Brandon D. 
Published: May 2015

Educational Objectives

As a result of reading this article, physicians should be able to:

1.
Describe the concept of bundled payments and the potential applications of bundled payments in orthopedic surgery.

2.
For specific situations, outline a clinical episode of care, determine the participants in a bundling situation, and define care protocols and pathways.

3.
Recognize the importance of resource utilization management, quality outcome measurement, and combined economic-clinical value in determining the value of bundled payment arrangements.

4.
Identify the implications of bundled payments for practicing orthopedists, as well as the legal issues and potential future directions of this increasingly popular alternative payment method.

Bundled payments, the idea of paying a single price for a bundle of goods and services, is a financial concept familiar to most American consumers because examples appear in many industries. The idea of bundled payments has recently gained significant momentum as a financial model with the potential to decrease the significant current costs of health care. Orthopedic surgery as a field of medicine is uniquely positioned for success in an environment of bundled payments. This article reviews the history, logistics, and implications of the bundled payment model relative to orthopedic surgery. [
Orthopedics.
2015; 38(2):128–135.]
Can the external masculinization score predict the success of genetic testing in 46,XY DSD?
Authors: Su Ruthie , Adam Margaret P. , Ramsdell Linda , Fechner Patricia Y. , Shnorhavorian Margarett 
Published: May 2015

AbstractGenetic testing is judiciously applied to individuals with Disorders of Sex Development (DSD) and so it is necessary to identify those most likely to benefit from such testing. We hypothesized that the external masculinization score (EMS) is inversely associated with the likelihood of finding a pathogenic genetic variant. Patients with 46,XY DSD from a single institution evaluated from 1994–2014 were included. Results of advanced cytogenetic and gene sequencing tests were recorded. An EMS score (range 0–12) was assigned to each patient according to the team's initial external genitalia physical examination. During 1994–2011, 44 (40%) patients with 46,XY DSD were evaluated and underwent genetic testing beyond initial karyotype; 23% (10/44) had a genetic diagnosis made by gene sequencing or array. The median EMS score of those with an identified pathogenic variant was significantly different from those in whom no confirmed genetic cause was identified [median 3 (95% CI, 2–6) versus 6 (95% CI, 5–7), respectively (p = 0.02)], but limited to diagnoses of complete or partial androgen insensitivity (8/10) or 5α-reductase deficiency (2/10). In the modern cohort (2012–2014), the difference in median EMS in whom a genetic cause was or was not identified approached significance (p = 0.05, median 3 (95% CI, 0–7) versus 7 (95% CI, 6–9), respectively). When all patients from 1994–2014 are pooled, the EMS is significantly different amongst those with compared to those without a genetic cause (median EMS 3 vs. 6, p < 0.02). We conclude that an EMS of 3 or less may indicate a higher likelihood of identifying a genetic cause of 46,XY DSD and justify genetic screening, especially when androgen insensitivity is suspected.
Assessment of Quality of Life in Patients of Chronic Rhinosinusitis
Authors: Bist SS , Mishra Sarita , Agrawal Vinish , Gairola Priyanka 
Published: May 2015

ABSTRACT

Introduction
Chronic rhinosinusitis (CRS) is a global health problem affecting approximately 14% of the population of all age groups. CRS has a significant adverse impact on quality of life of the patients.

Objective
The aim of this study was to compare the quality of life of patients suffering from CRS with that of normal population and to assess the association between objective nasal endoscopic score, self-rated symptom score and quality of life (QoL) score.

Methodology
This was a prospective study conducted over a period of 12 months. A total of 110 cases of CRS and 50 normal subjects taken as controls were recruited from out patients department. Patients diagnosed as a case CRS were subjected to rhinosinusitis disability index (RSDI), subjective QoL questionnaires and self-rated symptom score in their vernacular language followed by diagnostic nasal endoscopy, using 0° rigid endoscope (4 mm).

Results
This study revealed that the mean ± SD total QoL score in the patients was 50.2 ± 14.9 (15-94) which was significantly affected as compared to control group where it was only 18.2 ± 9.15 (3-47). The mean ± SD of the functional, emotional and physical domains were 17.6 ± 5.46 (4-34), 16.5 ± 8.29 (5-88) and 16.5 ± 5.84 (2-35) respectively. There was no correlation between endoscopic score and the patient's self-rated symptom score or RSDI score. The correlation between the self-rated symptom score and total QoL score was significant (p = 0.02).

Conclusion
On comparing the QoL in the patients of CRS with the controls, it was observed that QoL was affected more in the patients of CRS in the physical, functional and emotional domain of their life. CRS has considerable adverse impact on QoL of patients and RSDI is a valuable tool in assessing the QoL in patients of CRS.

How to cite this article
Gairola P, Bist SS, Mishra S, Agrawal V. Assessment of Quality of Life in Patients of Chronic Rhinosinusitis. Clin Rhinol An Int J 2014;7(3):96-99.
Frontal Meningoencephalocele: Changing Trends
Authors: Patro Sourabha K , Nabh Varun 
Published: May 2015

ABSTRACT
Frontal sinus defects involving the posterior table has always been challenging for the otolaryngologists. It traditionally involved open approaches like osteoplastic approach for the repair of defects or fractures involving the posterior table of frontal sinus. Better instrumentation, technique, and experience have increased the feasibility of endoscopic repair of frontal sinus skull-base defects. With the increased possibilities of endoscopic approach and instrumentation for the frontal sinus, an endoscopic repair of a posterior table defect with a meningoencephalocele in a long standing post-traumatic case has been described.

How to cite this article
Gupta AK, Patro SK, Nabh V. Frontal Meningoencephalocele: Changing Trends. Clin Rhinol An Int J 2014;7(3):125-129.
Congenital Lateral Nasal Proboscis with Orbital Mass
Authors: Saikia Uma Nahar , Kaur Balwinder 
Published: May 2015

ABSTRACT
Proboscis lateralis is a rare craniofacial malformation frequently associated with congenital ocular abnormalities. These abnormalities included anophthalmia, microphthalmia, microcornea, lenticular opacities, cyclopean eye, and colobomas of the choroid, retina, iris and eyelids. We report a case of unilateral proboscis lateralis in a newborn infant with an associated solid orbital mass.

How to cite this article
Kaur B, Bansal S, Saikia UN, Gupta P. Congenital Lateral Nasal Proboscis with Orbital Mass. Clin Rhinol An Int J 2014;7(3):139-141.