bluuebunny/crossref_metadata_2025_split huggingface dataset:
A163: Alternative Mechanisms of Care Delivery in Pediatric Rheumatology: To What Extent Do They Expand the Reach of Pediatric Rheumatologists?
Authors: Riebschleger Meredith P. , Tootoo Joshua , Mroczek Amanda , Clark Sarah 
Published: March 2014

Background/Purpose:Pediatric rheumatology (PR) practitioners are concentrated in academic centers, rather than being evenly distributed throughout the US. Alternative mechanisms of care delivery, such as secondary clinic sites and telemedicine, may function as a bridge between PR practitioners and children who live far from academic centers. The objective of this study was to determine the prevalence and distribution of alternative mechanisms of care delivery in US PR practices.Methods:PR practices were identified using the American College of Rheumatology member directory and the Children's Hospital Association hospital directory. Practice websites were reviewed to obtain data regarding secondary clinic sites and use of telemedicine. Practices were then called to confirm website data and obtain data not available on websites. Distance between each main and secondary clinic site was calculated. Geographic information system (GIS) was used to integrate study data with census data.Results:77/90 PR practices participated in phone calls and were included in analyses. 46 practices (60%) reported using secondary clinic sites; the number of secondary sites per practice ranged from 1–6 (total 96 sites). Frequency of clinics at secondary sites ranged from weekly to once per year; >80% of sites held clinics at least once each month. Distance from the main practice site to secondary clinic sites ranged from 6.2 to 2265 miles, with 65% (62/96) <60 miles from the main practice site and almost half (47/96) <30 miles from the main practice site. Census data indicate that 39% of US children live >60 miles from a main practice site and 30% of US children live >60 miles from any PR clinic site. Of the 12 states without a PR practice, 3 were served by secondary clinic sites. Seven practices (9%) reported telemedicine capability, but only 3 (4%) reported ever using it.Conclusion:Though most PR practices utilize secondary clinic sites, nearly 2/3 of those sites are <60 miles from the main practice site and nearly 1/3 of US children live far (>60 miles) from any PR clinic site. Few practices currently use telemedicine. Therefore, it is not clear that secondary clinic sites and telemedicine, as currently employed, significantly expand the reach of PR practitioners. Future studies should investigate the efficiency and effectiveness of alternative mechanisms of care delivery, to determine how best to serve children who live far from academic centers.
A166: Evaluation of Quality Indicators and Disease Damage in Childhood‐Onset Systemic Lupus Erythematosus Patients
Authors: Harris Julia G. , Maletta Kristyn I. , Kuhn Evelyn M. , Olson Judyann C. 
Published: March 2014

Background/Purpose:Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect virtually every organ system and may lead to significant morbidities. A recent publication identified quality indicators specific to childhood‐onset SLE (cSLE) based on scientific evidence and expert opinion. Our study measured compliance with certain quality indicators and assessed organ‐specific dysfunction in our cSLE population using a validated damage index, which will help define a baseline for which to optimize management and focus treatment to control the underlying disease and prevent adverse effects of therapy.Methods:A retrospective chart review was performed on patients diagnosed with SLE prior to age 18 who were followed in the Children's Hospital of Wisconsin Rheumatology Clinic for at least one year between January 1999 and August 2012. The Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index was calculated to assess for chronic damage.Results:Analysis was performed on 75 patients with mean disease duration of 4.55 years. Eighty‐four percent of patients were female, 38.7% were black, 14.7% were Hispanic, and mean age of diagnosis was 13.2 years. The proportion of patients for whom care met the proposed quality indicators include: hydroxychloroquine use 94.6%, discussion of cardiovascular risk factors 17.3%, bone mineral density testing 26.7%, Vitamin D recommendation 81.3%, ophthalmologic examination 49.0%, influenza vaccination 70.3%, pneumococcal vaccination 25.3%, and meningococcal vaccination 47.2%. Disease damage was present in 41.3% of patients with average overall damage index score of 0.81. The most common entities leading to a damage score were cataracts, avascular necrosis, and diabetes. There was an association of disease damage at last follow‐up with minority race (p = 0.008) and with presence of vitamin D recommendation (p = 0.005). On the contrary, there was no statistical significance relating disease damage to lupus nephritis, age at diagnosis, body mass index, hydroxychloroquine use, or discussion of cardiovascular risk factors.Conclusion:Baseline application of proposed quality indicators in our cSLE population is varied ranging from 17.3% to 94.6%. This data is important to standardize care and target certain domains of disease management for improvement such as education and vaccination. The three most common areas of damage in our study may be related to corticosteroid use. This knowledge of organ‐specific damage is important to help identify at‐risk patients to optimize care and focus quality improvement efforts.
A172: Metaphyseal Chondrodysplasia, Ectodermal Dysplasia, Short Stature, Hypergammaglobulinemia, and Spontaneous Inflammation Without Infections in an Extended Family Due to Mutation in NFKB1A
Authors: Oberle Edward J. , Verbsky James W. , Routes John , Hintermeyer Mary , Worthey Elizabeth , Dasu Trivikram , Bengtson Christine , Buzzell Alyssa 
Published: March 2014

Background/Purpose:Autoinflammatory disorders are characterized by chronic inflammation and a variety of systemic complaints. Defects in the NF‐kB essential modifier pathway, or NEMO, are associated with an immune deficiency characterized by ectodermal dysplasia. We investigated an extended family with features of both chronic inflammation and NEMO following an autosomal dominant inheritance.Methods:Eight individuals from one family were evaluated. The proband, a male patient age 12 with known hypohydrosis, presented to our rheumatology clinic for chronic articular pain with bony hypertrophy of wrists, knees, and ankles. Plain radiographs and standard labs were obtained including ESR, CRP, CBC, and immunoglobulins for all affected individuals. Films were reviewed by two musculoskeletal radiologists. The proband underwent a proximal tibial bone biopsy, as well as genetic testing for known autoinflammatory disorders and mutations in NF‐kB pathway. The Tolllike Receptor (TLR) assay was used to evaluate NF‐kB function.Results:The proband, his father age 30, two brothers age 7 and 9, and his 2‐year‐old sister were all found to have ectodermal dysplasia, short stature and failure to thrive, chronic inflammation, elevated WBC, and hypergammaglobulinemia (Figure ). Radiographs of proband displayed sclerotic lesions of the metaphyses of distal radius/ulna, distal femora, and proximal and distal tibia/fibula (Figure ). The patient's father was evaluated as a child for bone issues, and radiographs demonstrate widened metaphyses of distal ulna and tibia. Bone biopsy of the proband was consistent with metaphyseal chondrodysplasia. Genetic testing for known autoinflammatory disorders was negative while testing of the NFKB1A gene demonstrated a heterozygous mutation (W11X). TLR responses were normal in two affected individuals indicating intact NF‐kB signaling. No infections were noted in the family.
Family pedigree.imageProband radiographs.imageConclusion:This series demonstrates the clinical variability that can occur due to mutations in NFKB1A. Infections were not prevalent in this family, but spontaneous inflammation was common. In addition, this is the first report of metaphyseal chondrodysplasia as a complication of NEMO or related disorders.
A179: Improving Pneumococcal Vaccination Rate in the Pediatric Rheumatology Clinic
Authors: Harris Julia G. , Maletta Kristyn I. , Ren Bixiang , Olson Judyann C. 
Published: March 2014

Background/Purpose:This quality improvement project was conducted to increase pneumococcal vaccination rates in eligible Pediatric Rheumatology Clinic patients. Streptococcus pneumoniae is a leading cause of bacteremia, meningitis, pneumonia, sinusitis, and acute otitis media. Many patients in the Pediatric Rheumatology Clinic are at increased risk of pneumococcal disease secondary to a deficient immune system and/or immunosuppressive medications. Infections remain one of the leading causes of hospitalization and death in patients with certain rheumatic diseases. The Centers for Disease Control and Prevention recommends both the 13‐valent pneumococcal conjugate vaccine (PCV13) and the 23‐valent pneumococcal polysaccharide vaccine (PPSV23) for this high‐risk population.Methods:Baseline immunization rates were assessed for eligible clinic patients over a four week period. Eligible patients include children at least two years old and adults with systemic lupus erythematosus and patients currently on or starting an immunosuppressive medication. Interventions included a presentation to rheumatology providers and nurses, creation of clinic document with immunization algorithm, previsit planning, placing reminders on patient clinic forms, and sending letters to out‐of‐state patients. Chart reviews of eligible patients occurred throughout the study period. Control charts were established to portray change in immunization rate.Results:The pre‐intervention immunization rate for 90 eligible Pediatric Rheumatology Clinic patients was 6.7% for PCV13, 8.9% for PPSV23, and 0% for both vaccines. Data from 53 weeks were analyzed following the interventions for a total of 1123 eligible patient visits and 306 separate patients. The average post‐intervention immunization rate was 48.4% for PCV13, 28.4% for PPSV23, and 23.3% for both vaccines. These rates are statistically higher than the pre‐intervention rates (all p < 0.001). There was an increase in immunization rates following each major intervention. imageConclusion:Pneumococcal vaccination is an important part of the care for systemic lupus erythematosus patients and pediatric rheumatology patients on immunosuppressive medications. Simple interventions through this quality improvement project led to a marked increase in pneumococcal vaccination rates in this vulnerable population.
A181: Evaluating Decision‐Making in a Pediatric Rheumatology Clinic
Authors: David Jennie G. , Langer David A. , Kelso Gwendolyn , Lo Mindy S. 
Published: March 2014

Background/Purpose:Children with rheumatic disease often have chronic needs that require comprehensive, lifelong medical care. Transition of adolescent rheumatology patients from pediatric to adult institutions, in addition to a shift in legal responsibility, calls for the development and activation of medical decision‐making skills. Medical decision‐making is the umbrella term for the dynamic and evolving process of arriving at a medical decision, and is comprised of multiple factors including adherence, self‐management, patient activation, health consciousness, and patient empowerment. This study assessed adolescent and caregiver medical decision‐making characteristics in the outpatient Rheumatology clinic of a pediatric tertiary care hospital. We hypothesized that (1) pediatric patients who are more involved in their care have lower decisional conflict (i.e., conflict over making a medical decision), (2) adolescents want to be involved in their care, and (3) higher health consciousness is positively correlated with valuing involvement in medical decision‐making, actual involvement in decision making, and lower decisional conflict.Methods:This was an anonymous survey study of adolescent patients with chronic rheumatologic illness and their caregivers presenting to the outpatient Rheumatology clinic at Boston Children's Hospital. Both adolescent and caregiver surveys included measures pertaining to health consciousness, medical values, potential barriers to involvement in care, decisional conflict, perceived actual involvement, and desired involvement.Results:A total of twenty‐eight adolescent'caregiver pairs completed the survey. The mean age of adolescents was 16.14 years old (SD = 2.5). There was a significant positive correlation between adolescent and caregiver health consciousness (r = 0.43, p = 0.027). Valuing involvement in medical decision‐making by adolescent patients was positively correlated with their perception of actual involvement (r = 0.39, p = 0.04) and with their level of health consciousness (r = 0.48, p = 0.009). Furthermore, adolescent perception of actual involvement in medical decision‐making correlated negatively with their feelings of decisional conflict (r = −0.64, p <0.001).Conclusion:Adolescent patients with chronic rheumatic disease have considerable motivation for involvement in care. Given the link between treatment adherence and medical decision‐making, the characteristics of medical decision‐making in the pediatric rheumatology population are a valuable area for future research.
Heterogeneous Catalysis of Multiple‐Electron‐Transfer Reactions at Nanoparticle‐Modified Electrodes
Authors: Laborda Eduardo , Neumann Christopher C. M. , Wang Ying , Ward Kristopher R. , Molina Ángela , Compton Richard G. 
Published: March 2014

AbstractIn some important electrochemical systems, the degree of electro‐reduction (or electro‐oxidation) of the reactant at the electrode surface depends on the extent of a surface‐catalysed reaction that involves intermediates formed by electron transfer. The catalytic properties of the electrode surface towards this heterogeneous reaction, therefore, can control the final product of important processes, such as the electro‐reduction of oxygen and some organic compounds. The modelling of the EChetEfd mechanism (where Chet is a heterogeneous chemical reaction and Efd indicates that the second electron transfer is fully driven) is considered in this paper at nanoparticle‐modified electrodes and homogeneous surface macroelectrodes. The influences of the chemical and electrochemical kinetics as well as the characteristics of the mass transport are investigated. The results enable us to propose procedures for the identification and characterisation of the surface‐catalysed process and for the optimisation of electrode modifications.
Interaction between Anions and Cationic Metal Complexes Containing Tridentate Ligands with exo‐CH Groups: Complex Stability and Hydrogen Bonding
Authors: Martínez‐García Héctor , Morales Dolores , Pérez Julio , Puerto Marcos , del Río Ignacio 
Published: March 2014

Abstract[Re(CO)3([9]aneS3)][BAr′4] (1), prepared by reaction of ReBr(CO)5, 1,4,7‐trithiacyclononane ([9]aneS3) and NaBAr′4, forms stable, soluble supramolecular adducts with chloride (2), bromide, methanosulfonate (3) and fluoride (4) anions. These new species were characterized by IR, NMR spectroscopy and, for 2 and 3, also by X‐ray diffraction. The results of the solid state structure determinations indicate the formation of CH⋅⋅⋅X hydrogen bonds between the anion (X) and the exo‐CH groups of the [9]aneS3 ligand, in accord with the relatively large shifts found by 1H NMR spectroscopy in dichloromethane solution for those hydrogens. The stability of the chloride adduct contrasts with the lability of the [9]aneS3 ligand in allyldicarbonyl molybdenum complexes recently studied by us. With fluoride, in dichloromethane solution, a second, minor neutral dimeric species 5 is formed in addition to 4. In 4, the deprotonation of a CH group of the [9]aneS3 ligand, accompanied by CS bond cleavage and dimerization, afforded 5, featuring bridging thiolates. Compounds [Mo(η3‐methallyl)(CO)2(TpyN)][BAr′4] (6) and [Mo(η3‐methallyl)(CO)2(TpyCH)][BAr′4] (7) were synthesized by the reactions of [MoCl(η3‐methallyl)(CO)2(NCMe)2], NaBAr′4 and tris(2‐pyridyl)amine (TpyN) or tris(2‐pyridyl)methane (TpyCH) respectively, and characterized by IR and 1H and 13C NMR spectroscopy in solution, and by X‐ray diffraction in the solid state. Compound 6 undergoes facile substitution of one of the 2‐pyridyl groups by chloride, bromide, and methanosulfonate anions. Stable supramolecular adducts were formed between 7 and chloride, bromide, iodide, nitrate, and perrhenate anions. The solid state structures of these adducts (12–16) were determined by X‐ray diffraction. Binding constants in dichloromethane were calculated from 1H NMR titration data for all the new supramolecular adducts. The signal of the bridgehead CH group is the one that undergoes a more pronounced downfield shift when tetrabutylammonium chloride was added to 7, whereas smaller shifts were found for the 2‐pyridyl C(3)H groups. In agreement, both types of CH groups form hydrogen bonds to the anions in the solid state structures.
Multidentate Europium Chelates as Luminoionophores for Anion Recognition: Impact of Ligand Design on Sensitivity and Selectivity, and Applicability to Enzymatic Assays
Authors: Schäferling Michael , Ääritalo Timo , Soukka Tero 
Published: March 2014

AbstractThe design of photoluminescent molecular probes for the selective recognition of anions is a major challenge for the development of optical chemical sensors. The reversible binding of anions to lanthanide centers is one promising option for the realization of anion sensors, because it leads in some cases to a strong luminescence increase by the replacement of quenching water molecules. Yet, it is an open problem to gain control of the sensitivity and selectivity of the luminescence response. Primarily, the selective detection of (poly)phosphate species such as nucleotides has emerged as a demanding task, because they are involved in many biological processes and enzymatic reactions. We designed a series of pyridyl‐based multidentate europium complexes (seven‐, six‐, and five‐dentate) including sensitizing chromophores and studied their luminescence intensity and lifetime responses to different (poly)phosphates (adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), cyclic adenosine monophosphate (cAMP), pyrophosphate, and phosphate anions), and carboxyanions (citrate, malate, oxalacetate, succinate, α‐ketoglutarate, pyruvate, oxalate, carbonate). The results reveal that the number of free coordination sites has a significant impact on the sensitivity and selectivity of the response. Because of its reversibility, the lanthanide probes can be applied to monitor the activity of ATP‐consuming enzymes such ATPases and apyrases, which is demonstrated by means of the five‐dentate complex.
Amidines for Versatile Ruthenium(II)‐Catalyzed Oxidative CH Activations with Internal Alkynes and Acrylates
Authors: Li Jie , John Michael , Ackermann Lutz 
Published: March 2014

AbstractCationic ruthenium complexes derived from KPF6 or AgOAc enabled efficient oxidative CH functionalizations on aryl and heteroaryl amidines. Thus, oxidative annulations of diversely decorated internal alkynes provided expedient access to 1‐aminoisoquinolines, while catalyzed CH activations with substituted acrylates gave rise to structurally novel 1‐iminoisoindolines. The powerful ruthenium(II) catalysts displayed a remarkably high site‐, regio‐ and, chemoselectivity. Therefore, the catalytic system proved tolerant of a variety of important electrophilic functional groups. Detailed mechanistic studies provided strong support for the cationic ruthenium(II) catalysts to operate by a facile, reversible CH activation.
ChemInform Abstract: Structural, Vibrational and Electrical Properties of Ordered Double Perovskite Oxide BaLaMnSbO6.
Authors: Bharti Chandrahas , Sen A. , Chanda Sadhan , Sinha T. P. 
Published: March 2014

AbstractBaLaMnSbO6 is successfully synthesized by calcination of stoichiometric amounts of BaCO3, La2O3, MnO, and Sb2O5 (alumina crucible; 1.
ChemInform Abstract: Preparation and Luminescence Characteristics of Eu‐Doped Calcium Chloride Silicate Ca7Si2O8Cl6.
Authors: Wang Jing , Zhang Wanqi , Qi Shuyun , Guan Ying , Lu Juan 
Published: March 2014

AbstractEu‐activated Ca7Si2O8Cl6 phosphors are prepared by calcination of a stoichiometric mixture of CaCO3 and SiO2 in the presence of 0.1—5.0 mol% Eu2O3 (air, 850 °C, 5—10 h) before fluxing the resulting powder with CaCl2 (N2/5%H2 atmosphere, corundum boat, 1100 °C, 5—10 h).
ChemInform Abstract: Magnetic Properties of Tl9LnTe6, Ln: Ce, Pr, Tb and Sm.
Authors: Bangarigadu‐Sanasy Savitree , Sankar Cheriyedath Raj , Dube Paul A. , Greedan John E. , Kleinke Holger 
Published: March 2014

AbstractThe title compounds are prepared by reaction of stoichiometric mixtures of the elements (evacuated silica tube, 1.
ChemInform Abstract: Magnetic, Thermal and Electronic Properties of Ce11Ni4In9 and CeNi9In2.
Authors: Szytula A. , Baran S. , Penc B. , Przewoznik J. , Winiarski A. , Tyvanchuk Yu. , Kalychak Ya. M. 
Published: March 2014

AbstractPolycrystalline samples of Ce11Ni4In9 (I) and CeNi9In2 (II) are prepared by arc melting of the elements followed by annealing at 670 K for (I) and 870 K for (II).
ChemInform Abstract: A Reversible and Stable Flake‐Like LiCoO2 Cathode for Lithium Ion Batteries.
Authors: Wei Tao , Zeng Rui , Sun Yongming , Huang Yunhui , Huang Kevin 
Published: March 2014

AbstractA micro‐sized LiCoO2 cathode for lithium ion batteries with thick and dense flake morphology is synthesized from a mixture of CoO nanodisks (obtained from an aqueous solution of Co(OAc)2 and N2H4, followed by annealing at 300 °C for 2 h) and LiOH·H2O in EtOH solution (850 °C, 10 h).
ChemInform Abstract: Facile Synthesis of Nanostructured CuCo2O4 as a Novel Electrode Material for High‐Rate Supercapacitors.
Authors: Pendashteh Afshin , Rahmanifar Mohammad S. , Kaner Richard B. , Mousavi Mir F. 
Published: March 2014

AbstractCuCo2O4 particles in the shape of cauliflower‐like structures are prepared by sonication of an aqueous solution of Cu(NO3)2 and Co(NO3)2 at 50 °C for 1 h, followed by addition of urea and evaporation of water at 80 °C for 12 h.
ChemInform Abstract: Synthesis and Characterization of a New Organically Templated Open‐Framework Beryllium Phosphite with 3, 4‐Connected Networks.
Authors: Wang Guo‐Ming , Zhang Xiao , Li Jin‐Hua , Wang Pei , Wang Zong‐Hua , Wang Ying‐Xia , Lin Jian‐Hua 
Published: March 2014

AbstractThe new open‐framework compound (Hdien)2[Be3(HPO3)4] (dien: diethylenetriamine) is hydrothermally synthesized from a mixture of BeSO4, H3PO3, dien, ethylene glycol, and H2O (autoclave, 170 °C, 7 d, 84% yield).
ChemInform Abstract: Formation, Self‐Assembly and Transformation of a Transient Selenotungstate Building Block into Clusters, Chains and Macrocycles.
Authors: Cameron Jamie M. , Gao Jing , Vila‐Nadal Laia , Long De‐Liang , Cronin Leroy 
Published: March 2014

AbstractFive new selenotungstates are synthesized based on the formation and subsequent assembly of the previously unreported [Se2W12O46]12‐ building block.
ChemInform Abstract: Crystal Structure of Yb2CuGe6 and Yb3Cu4Ge4 and the Valency of Ytterbium.
Authors: Peter Sebastian C. , Subbarao Udumula , Sarkar Sumanta , Vaitheeswaran G. , Svane Axel , Kanatzidis Mercouri G. 
Published: March 2014

AbstractSingle crystals of Yb2CuGe6 (I) and Yb3Cu4Ge4 (II) are prepared by melting of the elements in a Y/Cu/Ge molar ratio of 3:2:6 and 3:3:6, resp., in an indium flux (alumina crucible in evacuated silica tube, 850 °C, 2 d, slow cooling).
ChemInform Abstract: Synthesis and Characterization of a Novel Quaternary Chalcogenide KBiCu2S3.
Authors: Zhang Ganghua , Zhang Bowen , Chen Haijie , Zhang Xian , Zheng Chong , Lin Jianhua , Huang Fuqiang 
Published: March 2014

AbstractKBiCu2S3 is prepared via a facile hydrothermal approach comprising aqueous solutions of KOH, Cu(OAc)2, Bi(NO3)3, and sulfur (autoclave, 240 °C 2—7 d).