bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ovarian senescence increases liver fibrosis in humans and zebrafish with steatosis
Authors: Turola Elena , Petta Salvatore , Vanni Ester , Milosa Fabiola , Valenti Luca , Critelli Rosina , Miele Luca , Maccio Livia , Calvaruso Vincenza , Fracanzani Anna L. , Bianchini Marcello , Raos Nazarena , Bugianesi Elisabetta , Mercorella Serena , Di Giovanni Marisa , Craxì Antonio , Fargion Silvia , Grieco Antonio , Cammà Calogero , Cotelli Franco , Villa Erica 
Published: July 2015

Contrasting data exist on the effect of gender and menopause on the susceptibility, development and liver damage progression in non alcoholic fatty liver disease (NAFLD). Our aim was to assess whether menopause is associated with severity of liver fibrosis in patients with NAFLD and to explore the issue of ovarian senescence in experimental liver steatosis in zebrafish.
In 244 females and age-matched males with biopsy-proven NAFLD we assessed anthropometric, biochemical, and metabolic features, including menopausal status (self-reported); liver biopsy was scored according to “The Pathology Committee of the NASH Clinical Research Network”. Young and old male and female zebrafish were fed for 24 weeks with a high-calories diet. Weekly BMI, histopathological examination, quantitative RT-PCR on genes involved in lipid metabolism, inflammation and fibrosis were performed.
In the entire cohort, at multivariate logistic regression, male gender (OR: 1.408, CI: 0.779-2.542, p=0.25) vs. women at reproductive age was not associated with F2-F4 fibrosis, while a trend was observed for menopause (OR: 1.752, 95%CI: 0.956-3.208, p=0.06). In women, menopause (OR: 2.717, 95%CI: 1.020-7.237, p=0.04) was independently associated with F2-F4 fibrosis. Similarly, in overfed zebrafish, old female fish with failing ovarian function [as demonstrated by extremely low circulating estradiol levels (1.4±0.1 pg/μl) and prevailing presence of atretic follicles in the ovaries)] developed massive steatosis and substantial fibrosis (comparable with that occurring in males) while young female fish developed less steatosis and were totally protected from development of fibrosis.
Ovarian senescence significantly increases the risk of fibrosis severity both in humans with NAFLD and in zebrafish with experimental steatosis.
Reactions of Carbonyl Compounds with Phosphorus Ylide Generated from Tribromofluoromethane and Tris(dimethylamino)phosphine
Authors: Hirai Go , Nishizawa Eri , Kakumoto Daiki , Morita Masaki , Okada Mitsuaki , Hashizume Daisuke , Nagashima Sayoko , Sodeoka Mikiko 
Published: July 2015

Abstract
The reactions of fluorinated ylide, generated from tris(dimethylamino)phosphine and tribromofluoromethane, with simple aldehydes and reactive ketones gave the expected Wittig reaction products. However, a ketone having a galactose skeleton afforded an acid fluoride, probably through an unprecedented Corey–Chaykovski-type epoxide formation reaction, followed by spontaneous Meinwald rearrangement.
Selective Detection of Iodine/Iodide Using BSA-stabilized Gold Nanoclusters-based Fluorescence Probe
Authors: Cao Xue-Ling , Luo Ya-Nan , Lian Li-Li , Wu Yu-Qing , Lou Da-Wei 
Published: July 2015

Abstract
In the present study BSA (bovine serum albumin)-stabilized Au nanoclusters (AuNCs@BSA) were demonstrated as a novel fluorescence probe for sensitive and selective detection of iodine/iodide. Beyond that, the proposed method was successfully applied to the determination of iodine in kelp, meanwhile, after iodide was changed to iodine with redox reactions, the detection of iodide could be successfully achieved using the AuNCs@BSA. This method could be used as a reliable, rapid, and cost-effective technique for the determination of iodine/iodide in real samples.
Simplified CRB-65 for risk stratification and predicting prognosis in acute pulmonary embolism
Authors: Coldewey M. , Dippold W. , Beule J. , Balzer J. O. , Keller K. 
Published: July 2015

SummaryBackground: Pulmonary embolism (PE) and community acquired pneumonia (CAP) are potentially life-threatening diseases. In CAP CRB-65 is used for risk stratification and prognosis prediction. The aim of this study was to examine a simplified CRB-65 (sCRB-65) for predicting prognosis in PE.Methods: We retrospectively analyzed the data of 182 PE patients. Patients were, according to the score of sCRB-65 (respectively 1 point for dyspnoea, systolic blood pressure < 90 mmHg or diastolic blood pressure60 mmHg, age65years), subdivided in risk-classes 1–4.Risk classes were compared with Kruskal-Wallis test. Logistic multivariable regression and Pearson correlation matrix were calculated for coherence of sCRB-65 and in-hospital death, right ventricular load and PE severity stadium as well as sCRB-65 > 2points and in-hospital death an PE stadium. ROC analysis was performed to evaluate efficiency of sCRB-65 score to predict in-hospital death and PE severity stadium.Results: PE severity stadium, systolic pulmonary artery pressure (sPAP) and frequency of in-hospital death increased with growing risk class.Risk class 1 showed lower PE sever-ity stadium than 2 (P=0.0253), 3 (P=0.0132) and 4 (P=0.00162), lower percentage of patients with sPAP > 30mmHg than 2 (0 % vs. 48.9 %, P=0.0419), 3 (0 % vs. 70.8 %, P=0.00112) and 4 (0 % vs. 75.0 %, P=0.0113). Frequency of in-hospital deaths was higher in risk class 4 than in 1 (P=0.0024), 2 (P=0.00014) and 3 (P=0.000058). Multi-variable logistic regression showed an association between sCRB-65 scored>0 and PE severity stadium (OR 11.42, 95 %CI: 1.35–96.66, P=0.0254), RVD (OR 10.09, 1.16–87.78, P=0.0363) and sPAP (OR 1.08, 1.02–1.15, P=0.0092) as well as a trend towards significance (OR 12.39, 0.90–171.34, P=0.060) between in-hospital death and sCRB-65. sCRB-65 correlated with PE severity stadium (r=0.258, P<0.001) and sPAP (r=0.280, P=0.001). sCRB-65 >2 points was strongly associated with both inhospital death (OR 36.22, 95%CI: 1.59–827.71, P=0.0245) and high-risk PE stadium (OR 57.94, 95%CI: 7.17–468.33, P=0.000141). ROC analysis for CRB-65 predicting in-hospital death and high-risk PE stadium showed AUC values of respectively 0.764 and 0.892 with sCRB-65 cut-off value of 2.5 points, respectively.Conclusions: sCRB-65 is closely correlated with PE severity stadium and load of the right heart as well as prognosis. PE patients with sCRB-65 score >2 points revealed a 36.2-fold risk to die during in-hospital course after acute PE event. Efficiency of sCRB-65 to predict in-hospital death was good.
Paget-Schroetter Syndrome
Authors: Pasternak A. , Szura M. , Matyja A. , Sułkowski L. 
Published: July 2015

SummaryPaget-Schroetter Syndrome is a primary, effort vein thrombosis of the axillo-subclavian level. It occurs predominantly after repetitive sport movements in the dominant limb in young healthy male individuals. Patients refer with pain, swelling and blue discolouration in the affected upper extremity.We present a 33-years-old woman with primary thrombosis of left subclavian vein, with no history of repetitive sport exercises or trauma. The patient’s profession requiring leaning against the desk for hours daily could be a trigger factor for vein thrombosis in presented case. Doppler ultrasonography and venography showed complete occlusion of left subclavian vein. Computed tomography showed no evidence for compression at thoracic outlet level. Patient was successfully treated with anticoagulants and followed for 21 months with repeated duplex ultrasound examinations. The symptoms had resolved. Long time left subclavian vein patency and good quality of life have been achieved.
Treatment of endovenous heat-induced thrombosis (EHIT) with rivaroxaban (Xarelto®)
Authors: Halbritter K. , Mahlmann A. , Weiss N. , Werth S. 
Published: July 2015

SummaryIntroduction: Endovenous heat-induced thrombosis (EHIT) is a known complication after endovenous ablation of the superficial varicose veins (incidence rate 0–6 % (varies by definition and diagnostic algorithm). However, only expert suggestions for indication, duration and dosing of treatment drugs exist. The most common recommendation is low-molecular weight heparin in half-therapeutic dosage for EHIT class 2 and therapeutic dosage for patients with EHIT class 3 or 4. Rivaroxaban is an attractive option in the treatment of venous thromboembolic diseases due to the simplification of treatment.Case report: After successful ablation of the great saphenous vein (GSV) in a patient with complete insufficiency (Hach III) combined with sclerotherapy of superificial varicose veins of the calf the patient got a prophylactic anticoagulation with low-molecular weight heparin (LMWH) and compressions stockings grade II. Nevertheless we saw in the control-compression ultrasound after 7 days an asymptomatic EHIT class 1. Due the progression to EHIT class 3 after another seven days under watchful waiting we treated the patient with Rivaroxaban for 14 days. After the treatment we saw a complete resolution of the clot. Anticoagulant treatment and compression stockings (for three weeks after EVLT) were discontinued.
Expert appraisal of venous diseases
Authors: Krämer K. , Wienert V. , Marshall M. 
Published: July 2015

SummaryUnusual features and problems at the expert assessment of vein damages and venous diseases are described, including indications for rational and evidence based diagnostics adapted to the needs. Besides it was an essential concern to point out important actual conceptual changes for the expert assessment in the legal scheme by the German social civil code (Sozialgesetzbuch VI). So the concepts of occupational disability (Berufsunfähigkeit) and of lost of earning capacity (Erwerbsunfähigkeit) don‘t exist in the legal pension scheme since 01st 01st 2001 any more. The idea of the “reduction in earning capacity” (Erwerbsminderung) has been introduced instead. There is still the concept of occupational disability (Berufsunfähigkeit) for the professional supply systems (berufsständige Versorgungswerke) and the private occupational disability insurances – but with different definitions and performances, which have to be taken into account if need be. Since the old definitions still frequently appear at the expert’s activcity, they are represented in these explanations briefly.In general, the scope and contents of expert appraisal records for venous diseases often constitute a sorry example of the general ignorance pertaining to the pathophysiology, clinical medicine, modern diagnostics and the significance of venous diseases, in both the sociomedical context and in occupational health.
Management of a severe soft-tissue infection after varicose vein surgery despite peripheral arterial occlusive disease
Authors: Cyrek A. , Bernheim J. , Juntermanns B. , Reinhardt R. , Burzec W. , Paul A. , Hoffmann J. N. 
Published: July 2015

SummaryWe describe a 65-year-old male with severe soft tissue infection of both lower legs. He had infected ulcer after stripping of small saphenous vein in tumescent anaesthesia and excision of side branches, and was referred from a foreign clinic. Intraarterial angiography of the pelvic and legs vessels showed severe stenosis in the left deep femoral artery and a tandem stenosis of superficial artery. A hybrid procedure with intraoperative percutaneus angioplasty combined with femoral xenogenic patch as well as local wound treatment with negative pressure wound therapy and subsequent mesh graft transplantation were carried out. We observed complete healing of ulcers within four weeks.
Erectile function improvement after endovenous varicosis therapy of the great saphenous vein
Authors: Zimbelmann M. , Cordes J. 
Published: July 2015

SummaryThere are no cases reported about endovascular varicosis therapy having an impact on the erectile function of the man. This case reports’ patient had a stronger erection in the area of the glans penis after he underwent endovenous lasertherapy of the great saphenous vein.This effect could also be explained with the anatomy of the veins because some of the blood of the penis is drained by the external pudendal vein which leads into the saphenofemoral junction. If there is a manipulation on the veins of the saphenofemoral junction it might have an impact on the drainage of the penis.
The Role of the Literary Theatrical Project in the Development of the Sociocultural Competence on English Classes (Based on Work Experience)
Authors: Диянова  , Diyanova O. 
Published: July 2015

In this article the author shares her experience on how
to develop sociocultural competence by means of the literary and
theatrical project on English classes. The Author&#180;s need of appealing
to the study of literature and theatreof the country which language
is learned is caused by the nowadays increased necessity in
cross-cultural communication and cooperation.
The search for the solution led to the idea to organize the process
of training English language on the basis of modern educational
technologies allowing to improve educational process, to increase
efficiency and quality of its organization. The method of projects
became one of the primary ones. The author offers the creative
project &#34;Literary Drawing Room&#34; with staging elements allowing
to create the language environment, maintaining interest in studying
of English and motivation for the new knowledge.
The theatrical project became another integral part of the educational
process organized by the author of this article. She refers to
the prominent educatorswho proved the expediency of carrying out
theatrical classes in general education process.
The participation of the drama school headed by the author of this
article in the International Theater Festivals in Russia and abroad,
receiving Grants and recognition are a bright confirmation of the
right choice of the literary and theatrical project as a way to polycultural
personality formation prepared for cross-cultural communication.
Intelligent Rating System of Students’ Interactive Learning
Authors: Чубаров  , Chubarov M. , Колокатова  , Kolokatova Larisa 
Published: July 2015

Computer systems of Interactive learning contribute to
quality education regardless of the place of students’residence and
ways of computer access, subject to the availability of developed
content that meets the requirements of modern high school. The
article presents Interactive technology of physical culture and sports
training for students’ integrated learning.
The condition of bodyfunctional systems is defined with the aim
of developing an effective strategy of physical training of university
students.
Students’ Activity Increase As Important Task of Foreign Language Teaching Process
Authors: Николаева  , Nikolaeva Viktoriya , Сенина  , Senina N. 
Published: July 2015

The article focuses on formative assessment; it demonstrates
a range of formative assessment tools used by experts in
trainers&#96; teaching and learning assessment within levelled courses
in the regions of the Republic of Kazakhstan.Authors demonstrate
the meaning of new approach to assessment and Expert’s actions
in trainers’ preparation for further training teachers within levelled
courses of teachers’ professional development program designed
by AEO “Nazarbayev intellectual schools” and Faculty of Education,
University of Cambridge.
Social Capital of Physical Culture in the Course of Solving Problems of Organization of Extra-Curricular Sports at Universities
Authors: Колокатова  , Kolokatova Larisa 
Published: July 2015

Physical culture (FC) is one of the factors for the formation
of social and human capital corresponding long-term objectives
of the Russian state. Achieved results can have serious practical
value: they show which indicators are reliable for modernization
of reforms of physical culture in education.
Oferta i reklama jako forma rozpowszechniania utworu w świetle art. 4 ust. 1 dyrektywy 2001/29/WE – oczywistość czy dylemat?
Authors: Trzebiatowski Marcin 
Published: July 2015

Pojęcie „jakiejkolwiek formy publicznego rozpowszechniania” utworu „w drodze sprzedaży lub w inny sposób” z art. 4 ust. 1 dyrektywy 2001/29/WE było interpretowane przez Trybunał Sprawiedliwości Unii Europejskiej początkowo dość wąsko. Wyłączano z niego sytuacje, kiedy nie dochodziło jeszcze do przejścia władztwa na egzemplarze utworu. W wyroku w sprawie Peek&Cloppenburg odniesiono to pojęcie wyłącznie do przeniesienia własności, sprzeciwiając się rozciąganiu go na umożliwienie korzystania z reprodukcji chronionego utworu, a tym bardziej na samo jej wystawienie na widok publiczny. Takie rozstrzygnięcie miało znajdować oparcie w wykładni pojęcia „publiczne udostępnianie drogą sprzedaży”, przewidzianego w traktatach WIPO o prawach autorskich oraz o artystycznych wykonania i fonogramach.Zmianę przyniósł wyrok w sprawie Donner, w którym Trybunał uznał, że ww. pojęcie wymaga w prawie UE wykładni niezależnej od prawa mającego zastosowanie do transakcji, w ramach których doszło do rozpowszechnienia, oraz wykładni oderwanej od ściśle cywilistycznego znaczenia sprzedaży, a bardziej uwzględniającej uwarunkowania rynkowe. Takim rozpowszechnianiem jest więc każda transakcja ukierunkowana na udostępnienie klientom kopii utworów chronionych w danym państwie, w tym reklamę informującą ich o systemie dostawy i zapłaty za te kopie.Tę nową koncepcję dopełnił wyrok w sprawie Blomqvist, dotyczący wykładni ww. pojęcia w związku z pojęciem „używania w obrocie handlowym” z przepisów UE o znakach towarowych i zarazem na tle regulacji o egzekwowaniu ochrony praw własności intelektualnej przez organy celne. Uznając tożsamość powyższych pojęć, TSUE przyjął, że jeśli według prawa państwa ochrony utworu za jego udostępnianie uważa się zarówno „publiczne rozpowszechnianie”, jak i sytuację, w której „oferowana jest sprzedaż, wynajem lub użyczenie jego kopii lub są one publicznie rozpowszechniane w inny sposób”, to wszystkie te działania należy uznać za rozpowszechnianie utworu, i to nawet wtedy, gdy dany towar pochodzi z państwa, w którym taka ochrona nie jest udzielana.Za słuszną należy więc uznać opinię rzecznika generalnego w sprawie Dimensione Direct Sales, który dopuścił stwierdzenie naruszenia prawa do rozpowszechniania utworu także w braku faktycznej sprzedaży jego egzemplarzy, jeśli tylko transakcja zakazana na podstawie tego prawa wpisuje się w kontekst wyraźnie sprzyjający zawarciu umowy sprzedaży. Taka interpretacja jest uzasadniona potrzebą zapewnienia autorom skutecznej kontroli nad komercjalizacją ich utworów, począwszy od ich reprodukcji, poprzez handel, aż do wyczerpania prawa.W konsekwencji, w ten sam sposób powinno być też rozumiane na tle art. 17 w zw. z art. 6 ust. 1 i 3 oraz art. 50 pkt 2-3 polskiego prawa autorskiego pojęcie korzystania z utworu.
Wierne czy piękne? Kilka uwag na temat pierwszego tłumaczenia Censorynusa na język polski
Authors: Kubiaczyk Monika Anna 
Published: July 2015

recenzja książki: Censorini, Liber De Die Natali ad Quintum Caerellium/Censorynus, Księga o dniu narodzin dla Kwintusa Caereliusza, przekł., wstęp i komentarz B.J. Kołoczek, Wydawnictwo Naukowe UAM, Poznań 2014 [=Fontes Historiae Antiquae, 30], 121 s
Między historią a teologią, czyli ks. dr. hab. Antoniego Żurka poszukiwanie tajemnic Eucharystii w późnoantycznym Kościele łacińskim,
Authors: Spychała Dariusz 
Published: July 2015

recenzja książki A. Żurek, ,,Mysterium Passionis-Corpus et Sanguis Christi-Communio”. Eucharystia sakramentem wtajemniczenia chrześcijańskiego w Kościele łacińskim czwartego i początku piątego wieku, Księgarnia św. Jacka, Katowice 2012, Studia Antiquitatis Christianae. Series Nova 14, 367 s.
Wielkopolski pomysł. O książce „Ofiary zabobonu” — reedycji (nakładem Gminy Kiszkowo),
Authors: Jakóbczyk Stanisław 
Published: July 2015

rec. książki F. Tuczyński, Ofiary zabobonu. Powieść obyczajowa z czasów polskich XVII [sic!] stulecia. Do druku podali, z oryginałem skoligacili A. Frąckowiak i B. Krakowski [;] Wstęp D. Jung [;] Ilustracje D. Sierzchulski [;] Gmina Kiszkowo 2012, 130 s.
To the problem of child studies in psychological and pedagogical heritage of A. Lazurskiy (early 20th century)
Authors: Inna Leoentyeva Inna 
Published: July 2015

Exploring the nature of a child, the child's personality, individual traits of character as well as peculiarities of formation and development in educational process is one of the main problems of modern pedagogy. The most significant contribution among scientists in the field of study of child and child’s individual features was made by A. Lazurskiy (1874-1917). The author determines that A. Lazurskiy was inclined to employ psychological knowledge in teaching practice and was deeply convinced that upbringing schoolchildren can rely on detailed and planned studies of child nature by means of psychological and pedagogical methods. Subsequently, the author demonstrates that A. Lazurskiy developed a versatile method for a holistic research of the personality of a child in the educational process – the natural experiment, and was the author of "experimental classes" as a valuable educational tools.
Composition-dependent depression of the glass transition temperature of the rubber phase in a PE-SBR blend
Authors: Yousefi Ali Akbar 
Published: July 2015

AbstractA thermoplastic elastomeric blend was introduced based on high-density polyethylene and styrene-butadiene rubber (SBR). The morphology of the blend system was found to change from two-phase to co-continuous, depending on the polyethylene (PE) concentration. The thermo-mechanical measurements showed that, at the PE concentrations, which seemed to have a co-continuous morphology, the SBR inclusions were very fine. The fineness of the SBR domains resulted in a 20° depression of the glass transition temperature (Tg) of the SBR phase. This was attributed to the smooth interfaces at which the SBR chain sensed a higher free volume as compared with that in bulk SBR. A model correlating thin polymer thickness to the Tg of the confined polymer in the films was employed to correlate SBR domain size to the experimental Tg measured. The adjusting parameters A=129 and δ=1.45 were successfully used to fit the experimental data.
Thermochemical and mechanical properties of tea tree (Melaleuca alternifolia) fibre reinforced tapioca starch composites
Authors: Rodney Jammy , Sahari Japar , Mohd Kamal Mohd Shah , Sapuan Salit Mohd 
Published: July 2015

AbstractWe aim to utilise the tea tree (Melaleuca alternifolia)fibre, a waste from the distillation process, as a reinforcement or filler in tapioca starch (TS) composites. Fabrication of tea tree fibre-reinforced TS composites was successfully developed using a casting method. The physical, thermo-chemical, and mechanical properties were tested in order to get the characterisation of the composites. From the mechanical test, the addition of 5% (v/v) tea tree fibre as a filler improved the tensile strength of the TS composites up to 34.39% in tea tree leaf-reinforced TS composites (TTL/TS), 82.80% in tea tree branch-reinforced TS composites (TTB/TS) and 203.18% in tea tree trunk-reinforced TS composites (TTT/TS). The water absorption and swelling of all tea tree fibre-reinforced composites decreased compared to those of TS composites. Most importantly, all parts of the tea tree waste, namely, the tea tree leaf, tea tree branch and tea tree trunk, have additional potential value as fibres that can act as a reinforcement in developing a green biocomposite.