bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of nitric oxide via cardiopulmonary bypass on pediatric heart surgery: a meta-analysis of randomized controlled trials
Authors: Zhao Minli , Zhang Qiuping , Lin Yuan , Chen Yukun , Cao Hua 
Published: July 2024

Abstract
Objective
The impact of nitric oxide (NO) administered via cardiopulmonary bypass (CPB) on pediatric heart surgery remains controversial. The objective of this study is to conduct a comprehensive systematic review and meta-analysis to examine the impact of NO administered via CPB on pediatric heart surgery.

Methods
This study searched 7 electronic databases to identify Randomized Controlled Trials (RCTs) on the impact of NO administration during CPB on postoperative outcomes in pediatric heart surgery. The searched databases included Embase, Medline (though PubMed), Cochrane Library, Web of Science, Wan Fang database, China National Knowledge Infrastructure (CNKI), and ClinicalTrials.gov from their inception to November 2, 2022. The included RCTs compared NO administration during CPB with standard CPB procedures or placebo gas treatment in pediatric heart surgery. fixed-effects models and/or random-effects models were used to estimate the effect size with 95% confidence interval (CI). Heterogeneity among studies was indicated by p-values and I2. All analyses were performed using Review Manager software (version 5.4) in this study.

Results
A total of 6 RCTs including 1,739 children were identified in this study. The primary outcome was duration of postoperative mechanical ventilation, with the length of hospital and intensive care unit (ICU) stay as the second outcomes. Through a pooled analysis, we found that exogenous NO administered via CPB for pediatric heart surgery could not shorten the duration of postoperative mechanical ventilation when compared with the control group (standardized mean difference (SMD) -0.07, CI [–0.16, 0.02], I2 = 45%, P = 0.15). Additionally, there were also no difference between the two groups in terms of length of hospital stay (mean difference (MD) -0.29, CI [–1.03, 0.46], I2 = 32%, P = 0.45) and length of ICU stay (MD -0.22, CI [–0.49 to 0.05], I2 = 72%, P = 0.10).

Conclusions
This meta-analysis showed that exogenous NO administration via CBP had no benefits on the duration of mechanical ventilation, the length of postoperative hospital, and ICU stay after pediatric heart surgery.
Letter to the editor: Re: Pathogenic mechanisms of osteogenesis imperfecta, evidence for classification
Authors: Dalgleish Raymond , Micha Dimitra , Superti-Furga Andrea , van Dijk Fleur S. , Sillence David O. 
Published: July 2024

AbstractA paper published in Orphanet Journal of Rare Diseases proposes a new classification of osteogenesis imperfecta (OI) based upon underlying pathological mechanisms. The proposed numbering of OI types conflicts with the currently used numbering and is likely to lead to confusion. In addition, classification of OI according to underlying pathogenic mechanisms is not novel.
Tau protein profiling in tauopathies: a human brain study
Authors: Lantero-Rodriguez Juan , Camporesi Elena , Montoliu-Gaya Laia , Gobom Johan , Piotrowska Diana , Olsson Maria , Burmann Irena Matečko , Becker Bruno , Brinkmalm Ann , Burmann Björn M. , Perkinton Michael , Ashton Nicholas J. , Fox Nick C. , Lashley Tammaryn , Zetterberg Henrik , Blennow Kaj , Brinkmalm Gunnar 
Published: July 2024

AbstractAbnormal accumulation of misfolded and hyperphosphorylated tau protein in brain is the defining feature of several neurodegenerative diseases called tauopathies, including Alzheimer’s disease (AD). In AD, this pathological change is reflected by highly specific cerebrospinal fluid (CSF) tau biomarkers, including both phosphorylated and non-phosphorylated variants. Interestingly, despite tau pathology being at the core of all tauopathies, CSF tau biomarkers remain unchanged in certain tauopathies, e.g., progressive supranuclear palsy (PSP), Pick’s disease (PiD), and corticobasal neurodegeneration (CBD). To better understand commonalities and differences between tauopathies, we report a multiplex assay combining immunoprecipitation and high-resolution mass spectrometry capable of detecting and quantifying peptides from different tau protein isoforms as well as non-phosphorylated and phosphorylated peptides, including those carrying multiple phosphorylations. We investigated the tau proteoforms in soluble and insoluble fractions of brain tissue from subjects with autopsy-confirmed tauopathies, including sporadic AD (n = 10), PSP (n = 11), PiD (n = 10), and CBD (n = 10), and controls (n = 10). Our results demonstrate that non-phosphorylated tau profiles differ across tauopathies, generally showing high abundance of microtubule-binding region (MTBR)-containing peptides in insoluble protein fractions compared with controls; the AD group showed 12–72 times higher levels of MTBR-containing aggregates. Quantification of tau isoforms showed the 3R being more abundant in PiD and the 4R isoform being more abundant in CBD and PSP in the insoluble fraction. Twenty-three different phosphorylated peptides were quantified. Most phosphorylated peptides were measurable in all investigated tauopathies. All phosphorylated peptides were significantly increased in AD insoluble fraction. However, doubly and triply phosphorylated peptides were significantly increased in AD even in the soluble fraction. Results were replicated using a validation cohort comprising AD (n = 10), CBD (n = 10), and controls (n = 10). Our study demonstrates that abnormal levels of phosphorylation and aggregation do indeed occur in non-AD tauopathies, however, both appear pronouncedly increased in AD, becoming a distinctive characteristic of AD pathology.
Menin inhibitors for acute myeloid leukemia: latest updates from the 2023 ASH Annual Meeting
Authors: An Zhuo-Yu , Zhang Xiao-Hui 
Published: July 2024

AbstractRecent developments in menin inhibitors for relapsed or refractory acute myeloid leukemia (AML) were highlighted at the 2023 ASH Annual Meeting. Notably, revumenib showed promising efficacy, achieving a 100% ORR when combined with decitabine/cedazuridine and venetoclax. These findings underscore the potential of menin inhibitors in transforming AML treatment, particularly in genetically defined subgroups, offering hope for improved patient outcomes. Ongoing studies, like KOMET-008, further explore the synergistic potential of menin inhibitors in combination regimens, shaping future AML management strategies.
Quantification method of ctDNA using cell-free DNA methylation profile for noninvasive screening and monitoring of colon cancer
Authors: Ryu Hyojung , Kim Ji-Hoon , Kim Yeo Jin , Jeon Hahyeon , Kim Byoung-Chul , Jeon Yeonsu , Kim Yeonkyung , Bak Hyebin , Kang Younghui , Kim Changjae , Um Hyojin , Ahn Ji-Hye , Hyun Hwi , Kim Byung Chul , Song Inho , Jeon Sungwon , Bhak Jong , Han Eon Chul 
Published: July 2024

Abstract
Background
Colon cancer ranks as the second most lethal form of cancer globally. In recent years, there has been active investigation into using the methylation profile of circulating tumor DNA (ctDNA), derived from blood, as a promising indicator for diagnosing and monitoring colon cancer.

Results
We propose a liquid biopsy-based epigenetic method developed by utilizing 49 patients and 260 healthy controls methylation profile data to screen and monitor colon cancer. Our method initially identified 901 colon cancer-specific hypermethylated (CaSH) regions in the tissues of the 49 cancer patients. We then used these CaSH regions to accurately quantify the amount of circulating tumor DNA (ctDNA) in the blood samples of these same patients, utilizing cell-free DNA methylation profiles. Notably, the methylation profiles of ctDNA in the blood exhibited high sensitivity (82%) and specificity (93%) in distinguishing patients with colon cancer from the control group, with an area under the curve of 0.903. Furthermore, we confirm that our method for ctDNA quantification is effective for monitoring cancer patients and can serve as a valuable tool for postoperative prognosis.

Conclusions
This study demonstrated a successful application of the quantification of ctDNA among cfDNA using the original cancer tissue-derived CaSH region for screening and monitoring colon cancer.
Is high exposure to antisocial media content associated with increased participation in malicious online trolling? exploring the moderated mediation model of hostile attribution bias and empathy
Authors: Qiu Yuedong , Sun Qi , Wu Biyun , Li Fang 
Published: July 2024

AbstractMalicious online trolling is prevalent among Chinese college students and has recently garnered extensive attention from researchers due to the substantial harm it causes to the victims and the damage it inflicts on the online environment. Most previous studies have focused on examining how personal traits related to malicious online trolling. Further comprehensive research is needed to explore the mechanisms linking external environmental factors (antisocial media exposure) and malicious online trolling. A total of 1259 Chinese college students completed questionnaires regarding malicious online trolling, antisocial media exposure, hostile attribution bias, and empathy. The results indicated a positive association between antisocial media exposure and malicious online trolling among Chinese college students, with hostile attribution bias serving as a mediating factor. Furthermore, the direct and mediated paths between antisocial media exposure and malicious online trolling were moderated by empathy. Specifically, as the level of empathy increased among college students, the relations between the variables all weakened. Excessive exposure to antisocial media content among college students may trigger hostile attribution bias and lead to more malicious online trolling behavior. However, the relation between antisocial media exposure and malicious online trolling, hostile attribution bias and malicious online trolling, was attenuated when college students’ empathy levels were high.
The iconographic evolution of Patagonian and Fuegian canids
Authors: Mayorga Marcelo , Barrios Natasha , González-Lagos César , Castro Sergio A. , Jaksic Fabián 
Published: July 2024

Abstract
Background
We assess the putative identity of canids accompanying the Patagonian and Fuegian aborigines through an iconographic timeline encompassing 1699–1894, when a number of narratives provided written descriptions and illustrations of those aborigines and their canids. We determine what type of “dogs” were those canids, disentangling their type or breed group, to reveal their characteristics, composition, and development during that period.

Methods
We searched for illustrations published by navigators and explorers where the presence of canids was reported in the historical territory of the Patagonian aborigines (Aónikenk, Kawésqar, Manek'enk, Sélk'nam, and Yahgan). We constructed a matrix to record the descriptions of all canids represented in those illustrations. Their characterization included body size, coat, tail, ears, skull, and attitude, among others. We then classified whether they were morphologically closer to domestic dogs or to foxlike canids. We used the morphological appearance of dogs to classify them into breed types, whenever possible.

Results and discussion
We identified and classified 61 canids from 26 illustrations in accounts published between 1699 and 1894. From a historical perspective, those accounts suggest that soon after the first contacts with Europeans, the Patagonian and Fuegian aborigines began to exchange and breed dogs of non-native origin, initiating an extended process of mixing between aboriginal foxlike canids and European dogs. From a cynological perspective, the foxlike canids associated with the aborigines were widely present only before 1833, exhibing an homogeneous appearance with a solid coat, pointed snout, small erect ears of high insertion, and fallen and bushy tail. After 1833, the canids depicted show a more varied appearance and mixed coat, with blunter snout, drooping ears at lower insertion, and erect fine tail with sparse hair. Most of these were hunting dogs morphologically similar to modern breeds such as pointers/setters, hounds, terriers, and retrievers.
Recurrent spontaneous coronary artery dissection with ST-segment elevation: once RCA involvement then left main/LAD—case report
Authors: Khaki Sara , Baradaran Rahimi Vafa , Ahmadi Mostafa 
Published: July 2024

Abstract
Background
Spontaneous coronary artery dissection is a rare disease with a more prevalence in women, mostly in the postpartum state, which was first described by Peretti in 1931.

Case presentation
This report describes a previously healthy woman who had a spontaneous coronary artery dissection. This case is related to the early postpartum period with a successful outcome. In addition, the diagnostic and therapeutic approaches of this unique clinical entity are discussed and reviewed.

Conclusions
Because these kinds of cases are so rare, reporting these cases and the management and treatment approaches can guide other clinicians worldwide, and maybe a guideline for choosing the best approach around different situations could be published.
Patterns of thyroid gland dysfunction among hospitalized patients with COVID-19 pneumonia
Authors: Morsi Fatima Al Taher Taha , Elgohary Marwan , Abdelmoaty Ahmed A. , Alsadik Maha E. , Shehata Samah M. , EL Maghawry Mohamed Ahmed 
Published: July 2024

Abstract
Background
Since the onset of the COVID-19 pandemic, multiple studies have reported a bidirectional between COVID-19 and dysfunction of the thyroid gland. These studies have identified various forms of thyroid dysfunction that have been found to affect the severity and outcome of COVID-19 infection. However, the data from these studies have been inconsistent and conflicting. Our objective was to assess the prevalence of various types of thyroid dysfunction among moderate to severe cases of COVID-19 pneumonia. In addition, the study aimed to evaluate the outcome of thyroid dysfunction after recovery from COVID-19 infection.

Patient and methods
In this observational prospective study data on the clinical features of individuals with moderate to severe COVID-19 pneumonia who were admitted to Zagazig University isolation hospitals from April to December 2022 and their laboratory results were gathered and examined. Thyroid function tests, including TSH, FT3, and FT4, were conducted for all patients upon admission. Follow-up testing was performed on patients who initially had aberrant thyroid lab results 90 days after recovering from COVID-19 infection.

Results
The study comprised a total of 136 patients who had moderate (44.1%) to severe (55.9%) COVID-19 infection. Sick euthyroid syndrome was the most prevalent form of thyroid dysfunction, accounting for 58.7% of patients with thyroid disorders on admission. After 90 days of post-COVID-19 examination, thyroid dysfunction recovery was observed in 61% of cases. A statistically significant correlation was noted between the severity of COVID-19 and the levels of TSH, free T3, and the ratio of free T3 to T4. A large percentage of patients who showed complete recovery had sick euthyroid syndrome. All patients diagnosed with primary hypothyroidism maintained their hypothyroidism condition, whereas those with hyperthyroidism showed complete recovery.

Conclusion
COVID-19 patients may experience several patterns of thyroid dysfunction, including nonthyroidal illness syndrome. These dysfunctions are associated with the intensity of the inflammatory response and the severity of the COVID-19 infection. Nevertheless, these alterations are predominantly reversible upon recovery from a COVID-19 infection.
Paclitaxel, Ifosfamide, and Cisplatin as Initial Salvage Chemotherapy for Germ Cell Tumors: Long-Term Follow-Up and Outcomes for Favorable- and Unfavorable-Risk Disease
Authors: Gleeson Jack P. , Knezevic Andrea , Bromberg Maria , Patil Sujata , Sheinfeld Joel , Carver Brett S. , Bains Manjit , Jones David R. , Bajorin Dean F. , Bosl George J. , McHugh Deaglan J. , Funt Samuel A. , Motzer Robert J. , Feldman Darren R. 
Published: July 2024

PURPOSE Paclitaxel, ifosfamide, and cisplatin (TIP) is an established salvage regimen for germ cell tumors (GCT) on the basis of a phase II trial, but efficacy on a large patient cohort including patients with unfavorable risk features and long-term outcomes has not been reported. Herein, we report updated treatment efficacy and long-term follow-up with TIP. PATIENTS AND METHODS Patients with GCT who received TIP after cisplatin-based chemotherapy were eligible. Favorable response (complete response or partial response with negative tumor markers), overall survival (OS) and progression-free survival (PFS) rates, relapse, and toxicity were determined. Disease was reclassified according to the International Prognostic Factor Study Group (IPFSG) score. RESULTS Of the 104 patients, 87 had favorable risk factors and 17 had at least one unfavorable factor by Memorial Sloan Kettering Cancer Center (MSKCC) criteria. Ten patients were treated for a second gonadal primary GCT. With a median follow-up of 8.9 years, the 5-year PFS and OS rates were 66% (95% CI, 55 to 74) and 69% (95% CI, 59 to 77), respectively. Among 87 patients with favorable-risk disease, 69 (79%) achieved a favorable response with 5-year PFS and OS rates of 67% (95% CI, 56 to 76) and 72% (95% CI, 61 to 80), respectively. Among 17 patients with MSKCC unfavorable-risk disease, 13 (76%) achieved a favorable response with 5-year PFS and OS rates of 59% (95% CI, 33 to 78) and 56% (95% CI, 28 to 76), respectively. After IPFSG reclassification, 5-year PFS and OS rates for patients with ≤intermediate-risk disease were 75% (95% CI, 50 to 89) and 73% (95% CI, 55 to 85), respectively. CONCLUSION TIP is an effective second-line regimen for patients with GCT. Similar outcomes were observed in patients with favorable- and unfavorable-risk disease. The randomized TIGER trial (ClinicalTrials.gov identifier: NCT02375204 ) comparing TIP with high-dose chemotherapy will determine the optimal second-line treatment approach.
Ontogenetic variation in metabolic rate–temperature relationships during larval development
Authors: Powers Sean D. , Grayson Kristine L. , Martinez Eloy , Agosta Salvatore J. 
Published: July 2024

ABSTRACT
Predictive models of ectotherm responses to environmental change often rely on thermal performance data from the literature. For insects, the majority of these data focus on two traits, development rate and thermal tolerance limits. Data are also often limited to the adult stage. Consequently, predictions based on these data generally ignore other measures of thermal performance and do not account for the role of ontogenetic variation in thermal physiology across the complex insect life cycle. Theoretical syntheses for predicting metabolic rate also make similar assumptions despite the strong influence of body size as well as temperature on metabolic rate. The aim of this study was to understand the influence of ontogenetic variation on ectotherm physiology and its potential impact on predictive modeling. To do this, we examined metabolic rate–temperature (MR–T) relationships across the larval stage in a laboratory strain of the spongy moth (Lymantria dispar dispar). Routine metabolic rates (RMRs) of larvae were assayed at eight temperatures across the first five instars of the larval stage. After accounting for differences in body mass, larval instars showed significant variation in MR–T. Both the temperature sensitivity and allometry of RMR increased and peaked during the third instar, then declined in the fourth and fifth instar. Generally, these results show that insect thermal physiology does not remain static during larval ontogeny and suggest that ontogenetic variation should be an important consideration when modeling thermal performance.
Competências-chave para sustentabilidade no contexto de mestrado profissional
Authors: Pires de Aguiar Ana Carolina , Monzoni Mario , Lourenço Goes Vicente 
Published: July 2024

Objetivo: O objetivo deste artigo é apresentar como as competências-chave dos profissionais da sustentabilidade podem ser desenvolvidas por meio de uma metodologia integradora de ensino aprendizagem que combina aspectos de desenvolvimento individual, relacional e prático.
Escopo: Apresentamos o caso da implementação da Formação Integrada para Sustentabilidade (FIS) no contexto de um Mestrado Profissional voltado a profissionais desta área.
Originalidade: A metodologia analisada evita simplificações, desenvolvendo as competências desejadas a partir de contextos práticos e em conjunto.
Relevância: Os professionais da sustentabilidade são cada vez mais valorizados diante dos crescentes e complexos desafios do modo de produção e consumo hegemônicos. Mais que habilidades “heroicas”, a sustentabilidade requer competências que permitam visão sistêmica e e engajamento contínuo com múltiplos atores e realidades.
Body Mass Index, Big Five personality traits and cyberchondria in a Polish women and men sample: A mediation model
Authors: Włodzimierz Oniszczenko 
Published: July 2024

Cel pracyCelem tego przekrojowego badania była ocena związku między wskaźnikiem masy ciała (BMI) a cyberchondrią w próbie mężczyzn i kobiet. W badaniu określono również znaczenie cech osobowości Wielkiej Piątki jako mediatorów tej relacji.MetodaUczestnikami było 329 kobiet i mężczyzn w wieku od 18 do 65 lat rekrutowanych online. BMI oszacowaliśmy na podstawie podanych przez uczestników danych o ich wzroście i aktualnej wadze. Do oceny cech osobowości Wielkiej Piątki wykorzystano Inwentarz Osobowości TIPI (Ten Item Personality Inventory). Cyberchondria została zdiagnozowana za pomocą Skali Cyberchondrii CSS-PL.WynikiBMI dodatnio korelowało ze stabilnością emocjonalną (przeciwieństwo neurotyczności) i ekstrawersją, natomiast ujemnie z cyberchondrią. Stabilność emocjonalna i ekstrawersja korelowały ujemnie z cyberchondrią. Jedynie BMI i stabilność emocjonalna były dobrymi predyktorami cyberchondrii. Kobiety uzyskały niższe wyniki w skali BMI i stabilności emocjonalnej, ale wyższe w skali cyberchondrii w porównaniu z mężczyznami. Analiza mediacji ujawniła bezpośredni i pośredni wpływ BMI na cyberchondrię poprzez stabilność emocjonalną jako mediatora między BMI a cyberchondrią.WnioskiBadanie to podkreśla możliwe znaczenie BMI dla cyberchondrii w zależności od stabilności emocjonalnej poszczególnych osób. Wyniki te mogą być przydatne dla profesjonalistów zajmujących się terapią osób z nadwagą/otyłością oraz osób nadmiernie używających Internetu.