bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anthracycline therapy induces an early decline of cardiac contractility in low-risk patients with breast cancer
Authors: Voß Fabian , Nienhaus Fabian , Pietrucha Saskia , Ruckhäberle Eugen , Fehm Tanja , Melz Tobias , Cramer Mareike , Haberkorn Sebastian M. , Flögel Ulrich , Westenfeld Ralf , Scheiber Daniel , Jung Christian , Kelm Malte , Polzin Amin , Bönner Florian 
Published: July 2024

Abstract
Aims
Cancer therapy-related cardiac dysfunction (CTRCD) is a dreaded complication of anthracycline therapy. CTRCD most frequently appears in patients with cardiovascular risk factors (CVR) or known cardiovascular disease. However, limited data exist on incidence and course of anthracycline-induced CTRCD in patients without preexisting risk factors.
We therefore aimed to longitudinally investigate a cohort of young women on anthracycline treatment due to breast cancer without cardiovascular risk factors or known cardiovascular disease (NCT03940625).

Methods and results
We enrolled 59 women with primary breast cancer and scheduled anthracycline-based therapy, but without CVR or preexisting cardiovascular disease. We conducted a longitudinal assessment before, immediately and 12 months after cancer therapy with general laboratory, electrocardiograms, echocardiography and cardiovascular magnetic resonance (CMR), including myocardial relaxometry with T1, T2 and extracellular volume mapping.
Every single patient experienced a drop in CMR-measured left ventricular ejection fraction (LVEF) of 6 ± 3% immediately after cancer therapy. According to the novel definition 32 patients (54.2%) developed CTRCD after 12 months defined by reduction in LVEF, global longitudinal strain (GLS) and/or biomarkers elevation, two of them were symptomatic. Global myocardial T2 relaxation times as well as myocardial mass increased coincidently with a decline in wall-thickening. While T2 values and myocardial mass normalized after 12 months, LVEF and GLS remained impaired.

Conclusion
In every single patient anthracyclines induce a decline of myocardial contractility, even among patients without pre-existing risk factors for CTRCD. Our data suggest to thoroughly evaluate whether this may lead to an increased risk of future cardiovascular events.

Graphical Abstract
Reduced myocardial contractility in low-risk patients receiving anthracycline-based cancer therapy.
This study included 59 otherwise healthy women with primary breast cancer undergoing anthracycline-based chemotherapy. CMR was performed at baseline, directly and 12 months after cancer therapy. A decline in left ventricular function was observed in every single patient accompanied by transient edema. More than 50% were diagnosed with cancer therapy related cardiovascular dysfunction.
LVEF: left ventricular function, CTRCD: cancer therapy related cardiovascular dysfunction, GLS = Global longitudinal strain, hs-TnT
= high sensitive Troponin T, NT-pro BNP = NT-pro brain natriuretic peptide
Organic farming to mitigate biotic stresses under climate change scenario
Authors: Biswas Saikat , Das Rupa 
Published: July 2024

Abstract
Background
Climate change is inevitable owing from modern-day chemical agriculture, exerting detrimental impacts on sustainable crop production. Global agriculture is now facing serious threats from biotic stresses like weeds, pests, diseases, etc. These stresses not only hamper growth and production but also reduce crop quality.

Main body of the abstract
Exclusive reliance on synthetic inputs to tackle biotic stresses has created resistance, resurgence, residues, etc., leading to environmental pollution. Although plants adopt defensive mechansims, such biotic stresses need to be addressed properly with various eco-friendly organic farming approaches. Suitable modification and adoption of various organic agronomic practices (manual, mechanical, cultural, and biological) such as soil solarization, crop rotation, intercropping, tillage, sowing time and method, nutrient, water and intercultural operations, organic formulations, selection of resistant/tolerant varieties, etc., can mitigate the negative impacts of biotic stresses to a high extent resulting in uplift in crop production as well as the quality of produce. Microorganisms not only alter soil health positively for high crop production but also alleviate biotic stresses through bio-stimulant properties. Various indigenous technical knowledge approaches show great promise to tackle biotic stresses further.

Short conclusion
Adequate research, integration of multiple technologies, build-up of awareness, etc., are the keys for successful organic plant protection under changing climate scenario.
Design, synthesis and evaluation of new methyl piperazine derivatives as anticancer agents
Authors: Singh Mahaveer , Jadhav Hemant R. , Choudhary Amit , Wadhwa Pankaj 
Published: July 2024

Abstract
Background
To overcome the problem of side effects and toxicity, development of new anticancer agents is needed. Recently, piperidine salicylanilide derivatives with nanomolar epidermal growth factor receptor (EGFR) inhibitory and cytotoxicity activity have been reported. In the present study effect of replacing piperidine in reported piperidine salicylanilide with N-methyl piperazine and changing substituent’s of phenyl ring at other end on anticancer activity have been explored. A series of sixteen methyl piperazine incorporated phenyl benzamide and phenyl methanone derivatives have been synthesized and tested in a panel of three cancer cell lines (adenocarcinomic human alveolar basal epithelial cells (A-549), human colon carcinoma (HCT-116) and human pancreatic carcinoma (MIAPaCa-2)), using gefitinib as standard. Further, to study the probable mechanism, due to their structural similarity with EGFR inhibitors, docking interactions with EGFR active site were observed using Schrodinger suite.

Result
The results indicated that most of the compounds showed promising activity; out of which, compound A-11 was most active having cytotoxicity much better than that of gefitinib. It showed IC50 value of 5.71 µM against A-549 cell line, 4.26 µM against HCT-116 colon cancer line and 31.36 µM against MIAPaCa-2 cell line.

Conclusion
It was found that these compounds fit well in the active site and may be exhibiting anticancer activity via EGFR inhibition.

Graphical Abstract
Differences in 21-Gene and PAM50 Recurrence Scores in Younger and Black Women With Breast Cancer
Authors: Van Alsten Sarah C. , Vohra Sanah N. , Ivory Joannie M. , Hamilton Alina M. , Gao Xiaohua , Kirk Erin L. , Butler Eboneé N. , Earp H. Shelton , Reeder-Hayes Katherine E. , Hoadley Katherine A. , Carey Lisa A. , Troester Melissa A. 
Published: July 2024

PURPOSE Genomic tests, such as the Oncotype Dx 21-gene and Prosigna risk of recurrence (ROR-P) assay, are commonly used for breast cancer prognostication. Emerging data suggest variability between assays, but this has not been compared in diverse populations. MATERIALS AND METHODS RNA sequencing was performed on 647 previously untreated stage I-III estrogen receptor–positive/human epidermal growth factor receptor 2–negative tumors in the Carolina Breast Cancer Study, which oversampled Black and younger women (age <50 years at diagnosis), using research versions of two common RNA-based prognostic assays: ROR-PR and the 21-gene recurrence score (RSR). Relative frequency differences and 95% CIs were estimated for associations with race and age, and hazards of 5-year local or distant recurrence were modeled with Cox regression. Proliferation and estrogen module scores from each assay, representing broad activity of genes in those pathways, were examined to guide interpretation of differences between tests. RESULTS Among both younger and older individuals, Black women had higher frequency of intermediate and high ROR-PR scores than non-Black women. Race was not significantly associated with RSR in either age group. High (hazard ratio [HR], 4.67 [95% CI, 1.73 to 12.70]) and intermediate (HR, 2.12 [95% CI, 0.98 to 4.62]) ROR-PR scores were associated with greater risk of recurrence, but RSR did not predict recurrence. RSR emphasized estrogen over proliferation modules, whereas ROR-PR emphasized proliferation. Higher proliferation scores were associated with younger age and Black race in both assays. Modifications to the RSR algorithm that increased emphasis on proliferation improved prognostication in this diverse population. CONCLUSION ROR-PR and the 21-gene RSR differentially emphasize estrogen-related and proliferative biology. The emphasis of 21-gene RS on estrogen-related biology and lower endocrine therapy initiation among Black women may contribute to poorer prognostic ability in heterogeneously treated populations.
Cryptography with stochastic photons
Authors: Shakhmuratov R. , Zinnatullin A. , Vagizov F. 
Published: July 2024

Abstract
Quantum cryptography protocols are based on the use of quantum objects with at least two orthogonal states, for example, the polarization states of a photon. We propose a completely different cryptography protocol using a stochastic flow of single photons. Our method is based on the stochastic decay of an ensemble of radioactive nuclei randomly emitting a stream of γ-photons. We have experimentally demonstrated the transmission of classical information containing binary bits. Reading this information requires precise knowledge of the repetition rate of its sending. Otherwise, it is impossible to make the transmitted information visible, since it will be lost in the noise.
Plotting a New Course for Environmental Humanities
Authors: Moulton Alex A. 
Published: July 2024

Abstract
This article suggests that the notion of “the plot” has methodological and epistemological value for the environmental humanities. Conceptualized in the work of Sylvia Wynter, the plot—as material site and narrative mode crucial to the novel form—offers a heuristic for analyzing the conjuncture of political economy, social-cultural aesthetics, and power. The plot names places that have been created through improvisational forms of world-making against racial and socioecological domination. The plot also names an insurgent scheme that is staged from peripheralized places and that is crucial to maintaining these spaces of insurgent living. Plotting is presented as an analytical mode that offers scholars in the environmental humanities: a framework for place-specific historical-geographical and ecological study; a critical cartographical praxis; and an approach for examining the logics and affective relations of place production. Environmental humanities scholarship that engages with Black ecocriticism along these lines is well positioned to examine the geographies of the past, present, and future with attention to the racial politics of human embodiment. Such scholarship would be characterized by more careful use of spatial metaphors, ensuring that ecocriticism and broader environmental humanities work considers the material and physical racial ecologies alongside the discursive and representational environments.
Is Long-Term Thinking a Trap?
Authors: Bastian Michelle 
Published: July 2024

Abstract
This provocation critiques the notion of long-term thinking and the claims of its proponents that it will help address failures in dominant conceptions of time, particularly in regard to environmental crises. Drawing on analyses of the Clock of the Long Now and Kim Stanley Robinson’s The Ministry for the Future, the article suggests that we be more wary of the concept’s use in what we might call chronowashing. Like the more familiar greenwashing, where environmental issues are hidden by claims to be addressing the problem, the article explores how these examples of long-term thinking distract from extractivism, racism, and environmental injustice, making it harder to address the complexities involved. In particular, the article discusses examples where long-term thinking provides a veneer of environmental concern that actually disconnects from the work of building more equitable forms of relation. As a contrast, the article’s author asks: What is lost when we diagnose a problem as arising due to short-term thinking and propose long-term thinking as the solution? Against chronowashed environmental time, the author argues for more complex approaches that explicitly take into account the temporalities of inequality, political organization, ethical responsibilities and much else. The article engages with approaches to time that foreground the work needed to create time and move ethically within it, including Charles W. Mills’s white time and Kyle Powys Whyte’s kinship time. The author suggests that a stronger emphasis on the temporality of community, solidarity, and coalition—versus what James Hatley and Deborah Bird Rose have described as temporal narcissism—can better foreground the kinds of work that needs to be done, particularly by those with privilege.
Communicating with Plants
Authors: Laist Randy 
Published: July 2024

Abstract
The Secret Life of Plants, a 1973 book that was developed into a 1979 documentary film, reports on a flurry of parapsychological research involving attempts to communicate with plants using electrodes, lie detectors, and psychic powers. The book highlights the work of Cleve Backster, an American researcher who claimed he could demonstrate that plants could read people’s minds and that measurements of his plants’ emotional responses to the randomized death of brine shrimp revealed empathetic connections “even on the lower levels of life.” Although this research appears risible in retrospect, Backster’s work expresses attempts to conceptualize plant subjectivity and plant agency against the backdrop of the emergent environmental movement. While it might be overly charitable to credit these experiments in plant communication with inspiring contemporary research into the ways plants share information with one another and with other species, Backster’s outlandish investigations suggest enduring object lessons for human beings in general and for the environmental humanities field in particular regarding the ways that plants continue to baffle us, to enchant us, and even, in their own weird way, to speak to us.
Hazardous Hope
Authors: Dhawan Ayushi , Müller Simone M. 
Published: July 2024

Abstract
This special section seeks to reconsider our troubled times and their histories of irreversible toxic pollution through the lens of hopeful yet critical ways of engaging with this unprecedented condition of life. Thinking with “hazardous hope” as a tool of analysis, the five contributions—combining perspectives from ecocriticism, environmental philosophy, film studies, visual arts, and history—showcase alternative presents and futures of living responsibly with a permanently polluted planet. Writing from the perspective of hazardous hope, the section’s editors argue, includes a plethora of conceptual and methodological repositionings to embrace the ambiguity that comes with living responsibly on a permanently polluted planet. Among them is a shift in focus on the acts and modes of hazardous hope as a relational practice that is focused on reorganizing established processes in radically different ways rather than wishing to achieve a predefined outcome, while at the same time remaining mindful of the polluted status quo. Contributions in this special section are situated across the entire troubled planet, from Chernobyl’s exclusion zone to Brazilian oil fields and from Canada’s tar sands to British asbestos-loaded homes.
Biportal Endoscopic TransOrbital and transMaxillary Approach to the Cranio-Orbital Region and Middle Cranial Fossa: A Preliminary Analysis of Maneuverability
Authors: Tariciotti Leonardo , Rodas Alejandra , Patel Biren , Zohdy Youssef M. , De Andrade Erion Jr , Revuelta Barbero Manuel , Porto Edoardo , Vuncannon Jackson , Maldonado Justin , Vergara Silvia M. , Lohana Samir , Solares C. Arturo , DiMeco Francesco , Garzon-Muvdi Tomas , Pradilla Gustavo 
Published: July 2024

BACKGROUND AND OBJECTIVES:
Traditional and well-established transcranial approaches to the spheno-orbital region and middle cranial fossa guarantee optimal intracranial exposure, and additional orbital and zygomatic osteotomies provide further control over extracranial components to be resected; however, these techniques come at the cost of additional morbidity. The introduction of minimally invasive endoscopic approaches and the conceptualization of the so-called “multiportal” paradigm might provide an alternative route. This preliminary study investigates the feasibility of the combined Biportal Endoscopic TransOrbital and transMaxillary Approach (bETOMA) approach to the spheno-orbital and middle cranial fossa regions.

METHODS:
Using 4 silicon-injected adult cadaver heads (8 sides; 16 approaches), we systematically dissected through superior eyelid ETOA and endoscopic TMA approaches. The analysis focused on pterygopalatine, infratemporal, anterior and middle cranial fossae, Meckel cave, and cavernous sinus access. We evaluated the feasibility of bETOMA using linear distances, angles of attack, and exposure areas. We also introduced volume of operative maneuverability, its standardized derivative (sVOM), target distance, visuo-operative angle, and working zone volume as novel metrics.

RESULTS:
The analysis revealed comparable angles of attack between approaches. ETOA and TMA exposure areas were 918.38 ± 223.93 mm2 and 257.07 ± 86.07 mm2, respectively. TMA showed a larger VOM in the greater sphenoid wing, but ETOA offered superior distal maneuverability (sVOM: 5.39 ± 1.94 vs 2.54 ± 0.79 cm3) and closer intracranial space access (27.45 vs 50.83 mm). The combined approaches yielded a mean working zone volume of 13.75 ± 3.73 cm3 in the spheno-orbital interface.

CONCLUSION:
The bETOMA approach provides adequate neurovascular exposure and maneuverability to the spheno-orbital region, infratemporal, and anterior and middle cranial fossae, addressing significant limitations of previously investigated monoportal techniques (ie, optic nerve decompression, hyperostotic bone resection, and infratemporal exposure). This combined minimally invasive approach might help manage lesions harbored within the cranio-orbital interface region invading the extracranial space.
On the Convex Formulations of Robust Markov Decision Processes
Authors: Grand-Clément Julien , Petrik Marek 
Published: July 2024

Robust Markov decision processes (MDPs) are used for applications of dynamic optimization in uncertain environments and have been studied extensively. Many of the main properties and algorithms of MDPs, such as value iteration and policy iteration, extend directly to RMDPs. Surprisingly, there is no known analog of the MDP convex optimization formulation for solving RMDPs. This work describes the first convex optimization formulation of RMDPs under the classical sa-rectangularity and s-rectangularity assumptions. By using entropic regularization and exponential change of variables, we derive a convex formulation with a number of variables and constraints polynomial in the number of states and actions, but with large coefficients in the constraints. We further simplify the formulation for RMDPs with polyhedral, ellipsoidal, or entropy-based uncertainty sets, showing that, in these cases, RMDPs can be reformulated as conic programs based on exponential cones, quadratic cones, and nonnegative orthants. Our work opens a new research direction for RMDPs and can serve as a first step toward obtaining a tractable convex formulation of RMDPs. Funding: The work in the paper was supported, in part, by NSF [Grants 2144601 and 1815275]; and Agence Nationale de la Recherche [Grant 11-LABX-0047].
Associations between different anatomical types of chronic rhinosinusitis and anxiety and depression
Authors: Chen Yanping , Jiang Juan , Xu Chuze , Chen Weijun , Geng Yan , Lei Chenyang 
Published: July 2024

Aims/Background Patients with chronic rhinosinusitis often have a higher incidence of anxiety and depression. Nevertheless, the impact of specific chronic rhinosinusitis types (chronic anterior/posterior/anterior and posterior rhinosinusitis) on anxiety and depression remains unexplored. Methods From January 2022 to July 2023, we employed various assessment scales to gauge the severity of chronic rhinosinusitis and anxiety and depression among Chinese patients with chronic rhinosinusitis. Statistical analysis involved non-parametric tests and binary logistic regression. Results In total, 123 patients with chronic rhinosinusitis were enrolled. The number of patients with anxiety and depression in the chronic posterior rhinosinusitis and chronic anterior and posterior rhinosinusitis groups (p=0.022), the nasal symptom subdomain scores of the chronic anterior rhinosinusitis and chronic anterior and posterior rhinosinusitis (p=0.011) groups and the chronic posterior rhinosinusitis and chronic anterior and posterior rhinosinusitis (p=0.008) groups, and the Lund-Kennedy score of the three groups (all p < 0.05) were significantly different. Binary logistic regression analysis revealed that chronic rhinosinusitis type (p=0.035) was a risk factor for anxiety and depression. Conclusion Anatomical chronic rhinosinusitis type was a risk factor for anxiety and depression in patients with chronic rhinosinusitis.
Hepatic arterial infusion chemotherapy combined with lenvatinib and PD-1 inhibitor for treating unresectable hepatocellular carcinoma
Authors: Bai Zhenhua , Yu Xianhuan , Tang Qibin , Zhang Rui , Shi Xiangde , Liu Chao 
Published: July 2024

Aims/Background The combination of lenvatinib and programmed cell death protein 1 (PD-1) inhibitor has demonstrated significant efficacy in treating unresectable hepatocellular carcinoma. Our study aimed to evaluate the safety and efficacy of triple therapy that includes hepatic arterial infusion chemotherapy, lenvatinib and PD-1 inhibitor for treating unresectable hepatocellular carcinoma. Methods Patients with a primary diagnosis of advanced hepatocellular carcinoma between June 2020 and August 2023 were included in this study. Initially, 53 patients with hepatocellular carcinoma were enrolled. Then, 13 patients were excluded based on the inclusion criteria, resulting in 40 patients included for analysis. Among them, 31 patients received triple therapy, including 16 Barcelona Clinic Liver Cancer C stage, 12 Barcelona Clinic Liver Cancer-B, and 3 Barcelona Clinic Liver Cancer-A hepatocellular carcinoma patients. The primary endpoint was the objective response rate, while the secondary endpoints included the conversion resection rate, pathological complete response rate, pathological partial response rate, and treatment-related adverse events. Results The objective response rate was 80.65% at a median follow-up of 24.5 months (range: 12.6–55.8 months). Of the 14 patients (45.2%) who underwent conversion therapy and were eligible for surgery, 7 patients underwent liver resection and the remaining 7 patients underwent liver transplantation. The median interval between the start of triple therapy and surgery was 117 days, ranging from 25 to 215 days. The pathological complete response was observed in six patients (19.4%) and the pathological partial response rate in eight patients (25.8%). All adverse events occurred in 77.4% of the patients. Conclusion In patients with unresectable hepatocellular carcinoma, the combination of hepatic arterial infusion chemotherapy, lenvatinib, and PD-1 inhibitor exhibits favourable efficacy and well tolerability, achieving a desirable pathological complete response rate while maintaining manageable drug toxicity.