bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin D deficiency at the Arctic Circle – a study in food‐allergic adolescents and controls
Authors: Persson Karin , Öhlund Inger , Nordström Lisbeth , Winberg Anna , Rönmark Eva , West Christina E 
Published: February 2013

AbstractAimAt the extremes of latitude, UVB intensity is insufficient for adequate vitamin D synthesis in winter. Fatty fish, vitamin D enriched milk, margarine and eggs are main dietary sources of vitamin D. Their elimination may increase the risk of vitamin D deficiency. The aim was to assess vitamin D status in food‐allergic adolescents eliminating milk, egg and/or fish compared with adolescents on normal diets.MethodsIn winter, vitamin D intake was assessed by a food frequency questionnaire in 20 food‐allergic adolescents and 42 controls in the population‐based Obstructive Lung Disease In Northern Sweden (OLIN) cohort studies. Vitamin D supplementation was queried. Serum 25‐hydroxyvitamin D [S‐25(OH)D] and S‐parathormone (S‐PTH) levels were determined.ResultsMean (SD) dietary vitamin D intake was 7.9 (3.6) μg/day in allergic adolescents and 7.8 (3.4) in controls (p > 0.05). Mean (SD) S‐25(OH)D levels in supplement consumers were 44 (18) nmol/L compared with 35 (10) in non‐consumers (p = 0.03). S‐25(OH)D and S‐PTH levels were similar in food‐allergic adolescents and controls (p > 0.05). Eighty‐two percentage had deficient S‐25(OH)D levels <50 nmol/L, and none reached levels >75 nmol/L.ConclusionVitamin D deficiency was as common in food‐allergic adolescents as in controls although the vitamin D intake met national recommendations. Large‐scale studies on the prevalence of vitamin D deficiency in this region are needed.
Melancholia, Mourning, Love: Transforming The Melancholic Response To Disability Through Psychotherapy
Authors: Bartram Pamela 
Published: February 2013

AbstractThe paper considers the unhappiness associated with disability and suggests that one strand of it can be understood in terms of narcissistic and melancholic states of mind. It refers to Freud's original distinction between mourning and melancholia, which highlights the self‐reviling characteristic of melancholia when a harsh superego attacks the ego in response to loss. Clinical examples from psychotherapy with a disabled adult and work with the parents of a young disabled child illustrate the ego's narcissistic retreat from the harsh superego and the concomitant problem of love. The paper suggests that it is the lack of love which may constitute the greatest unhappiness where there is disability. Through psychotherapeutic work melancholic states of mind can be transformed: the emergence of Britton's ‘rueful humour’ and an acknowledgement of impermanence are two signs that transformation is under way. The author suggests, in line with Buddhist thinking, that melancholia rather than mourning is the natural response to loss; the capacity to mourn is an attainment, not a given, and is a likely outcome of successful psychotherapeutic work where disability is a factor.
Urinary tract infection increases subsequent urinary tract cancer risk: A population‐based cohort study
Authors: Sun Li‐Min , Lin Cheng‐Li , Liang Ji‐An , Liu Shu‐Hui , Sung Fung‐Chang , Chang Yen‐Jung , Kao Chia‐Hung 
Published: February 2013

This study examines the possible association between urinary tract infection (UTI) and urinary tract cancer (UTC). Data from the National Health Insurance system of Taiwan were used for the analysis. The UTI cohort included 70 116 patients who were diagnosed and recruited between 1997 and 2010. Each patient was randomly frequency‐matched with two people without UTI from the general population based on their age, sex, and month of UTI diagnosis. Cox's proportional hazard regression analysis was used to estimate the effects of UTI on UTC risk until the end of follow‐up on December 31, 2010. Patients with UTI had a significantly higher risk of developing UTC than healthy people (adjusted hazard ratio, 4.66; 95% confidence interval, 3.55–6.10). Further analyses indicated that risks are potentially related to the level of the lesion site. This study indicated that patients with UTI had a higher risk of developing UTC.
Suppression of KIF14 expression inhibits hepatocellular carcinoma progression and predicts favorable outcome
Authors: Yang Tao , Zhang Xian‐Bo , Zheng Zhi‐Min 
Published: February 2013

The mitotic kinesin superfamily protein KIF14 is essential for cytokinesis and chromosome segregation and increased KIF14 expression is related to a variety of human cancers. In this study, we investigate KIF14 expression in association with clinical variables and the role of KIF14 during tumorigenesis. We found that KIF14 is overexpressed in most primary hepatocellular carcinoma (HCC) tissues compared with the adjacent normal liver tissues and KIF14 overexpression is associated with tumor grade (P = 0.002), stage (P = 0.013) and poor survival (P < 0.001). Downregulation of KIF14 decreased the capacity of proliferation both in vitro and in vivo. Furthermore, suppression of KIF14 not only decreases cancer cell migration but also induces apoptosis of cells with inactivation of the phosphatidylinositol 3‐kinase‐Akt signaling pathway. Therefore, our current study indicates that KIF14 promotes HCC carcinogenesis and may serve as a potential therapeutic target for human HCC.
Radiographic evaluation of the superior alveolar canal: measurements of its diameter and of its position in relation to the maxillary sinus floor: a cone beam computerized tomography study
Authors: Apostolakis Dimitrios , Bissoon Arlana K. 
Published: February 2013

AbstractObjectivesThe superior alveolar canal with its contents is frequently reported as an anatomical point of consideration during lateral sinus floor elevation due to the danger of bleeding and of the subsequent impairment of vision of the surgical field. Malnutrition of the graft may also ensue. This radiographical study uses cone beam computerized tomography to identify the superior alveolar canal, to measure its diameter and its distance from the sinus floor at precise tooth positions to provide the implant surgeon with information about the position and the diameter of the canal.Material and methodsOne hundred and fifty‐six patients (156) scanned with a Newtom VG device were included in this study. A dental and maxillofacial radiologist using the multiplanar capabilities of the device's software identified the canal and assessed its diameter and topography.ResultsThe canal could be identified in 82% of the cases with a mean diameter of 1.1 mm and a range of diameters between 0.2 and 2.6 mm. The distance from the floor of the sinus at various tooth positions ranged between 0 and 28.5 mm.ConclusionsIn the majority of our cases, the canal could be identified in at least one position, between the most posterior and the most anterior borders of the maxillary sinus. The large variation on the distance of the canal from the sinus floor dictates an individual evaluation of its position and not the use of mean values. Great care must be exercised by the radiologist to reliably identify the canal.
Prospective randomized controlled clinical study comparing two dental implant systems: demographic and radiographic results at one year of loading
Authors: Thoma Daniel S. , Sanz Martin Ignacio , Benic Goran I. , Roos Malgorzata , Hämmerle Christoph H. F. 
Published: February 2013

AbstractObjectiveTo compare the clinical and radiographic outcomes of implants and implant‐supported reconstructions using a 1‐piece (STM) and a 2‐piece (BRA) dental implant system.Material and methodsSixty patients were randomly assigned to receive STM or BRA implants. The implants restored with fixed or removable prostheses. Baseline measurements (day of loading) and 1‐year measurements included demographic and radiological parameters with details of the surgical procedures, type of prosthesis, survival of implants, and marginal bone‐level changes. The Mann–Whitney U‐test and the paired t‐test were used to analyze the data between the two groups and within the groups within 1 year on an implant‐ and patient‐based level.ResultsIn all 60 patients, implants were placed and supported 65 final reconstructions (33 BRA, 32 STM). One implant was lost in the STM group at 9 months (98.5% survival rate), none were lost in the BRA group (100%). On the implant level, the median marginal bone levels were −1.02 mm (interquartile range (IQR) 0.41 mm) at baseline and −1.08 mm (0.59 mm) 1 year later (BRA) and −0.51 mm (0.93 mm) and −0.75 mm (1.14 mm) (STM). The patient level values were −0.98 mm (0.47 mm) at baseline and −1.10 mm (0.71 mm) 1 year later (BRA) and −0.43 mm (0.59 mm) and −0.71 mm (0.97 mm) (STM). The differences between the two groups at both time‐points were statistically significant in the patient‐level analysis with higher bone levels for the STM group (P < 0.05). The changes in mean marginal bone levels on the implant level amounted to −0.05 mm (SD±0.32 mm) (BRA) and to −0.27 mm (±0.52 mm) (STM). Patient‐level values were −0.06 mm (± 0.37 mm) (BRA) and −0.25 mm (±0.35 mm) (STM). These differences between the groups reached statistical significance on the patient level with less bone loss in the BRA group (P < 0.05).ConclusionsWithin the first year of functional loading, high survival rates and minimal changes of marginal bone levels were found for both implant systems used.
The influence of prophylactic antibiotic administration on post‐operative morbidity in dental implant surgery. A prospective double blind randomized controlled clinical trial
Authors: Nolan Rory , Kemmoona Maher , Polyzois Ioannis , Claffey Noel 
Published: February 2013

AbstractObjectivesA prospective double‐blind randomised controlled trial was conducted to test the effect of prophylactic antibiotics on post‐operative morbidity and osseointegration of dental implants.Materials and MethodsFifty‐five subjects scheduled for implant surgery were enrolled. The patients were randomly assigned to the antibiotic (test group) and placebo (control group). Twenty‐seven patients (test group) received 3 g amoxicillin one hour pre‐operatively, and 28 patients (control group) received placebo capsules 1 h pre‐operatively. No post‐operative antibiotics were prescribed. Pain diaries and interference with daily activities diaries were kept by the patients for 1 week post‐operatively. Signs of post‐operative morbidity (swelling, bruising, suppuration and wound dehiscence) were recorded by the principal investigators at day 2 and day 7 following the operation. Osseointegration was assessed at 2nd stage surgery or 3–4 months post‐operatively.ResultsThe results of this study suggest that the use of prophylactic pre‐operative antibiotics may result in higher dental implant survival rates (100% vs. 82%). Five implant failures, one in each of five patients, were reported in the placebo group and none in the antibiotic group (P = 0.0515). No significant differences were found for most of the signs of post‐operative morbidity 2 and 7 days post‐operatively. Only bruising at 2 days following the operation appeared to be higher in the placebo group (P = 0.0511). Post‐operative pain (P = 0.01) and interference with daily activities (P = 0.01) appeared to be significantly lower for the antibiotic group after 7 days. Those patients with implant failure reported higher pain (based on the VAS scores) after 2 days (P = 0.003) and after 7 days (P = 0.0005), higher pain (based on the amount of analgesics used) after 7 days (P = 0.001) and higher interference with daily activities (based on the VAS scores) after 2 days (P = 0.005).ConclusionsThe use of for dental implant surgery may be justified, as it appears to improve implant survival in the short term and also results in less post‐operative pain and interference with daily activities. From the results of this study, it appears that prophylactic antibiotics may also be beneficial both in terms of implant survival, especially when the surgical procedure is prolonged due to its difficulty, high number of implants placed or operator's inexperience.
A new standardized‐automatic method for bone‐to‐implant contact histomorphometric analysis based on backscattered scanning electron microscopy images
Authors: Manresa Carolina , Bosch Manel , Manzanares María Cristina , Carvalho Patricia , Echeverría José Javier 
Published: February 2013

AbstractAimTo establish an image analysis procedure for measuring the bone‐to‐implant contact (BIC) by a systematic non‐subjective approach based on backscattered scanning electron microscopy (BS‐SEM) images.Material and methodsA total of 36 dental implants (9 mm length, Ø 4.0 mm with a SBM surface) were implanted in six beagle dog mandibles. The implants were removed after 1, 2, 4, 6, and 8 weeks and then embedded in resin and cut along their long axis. Sample observation was performed by BS‐SEM, acquiring 10 to 16 images per sample. Image processing and BIC determination were performed using the Fiji image processing package. Images were stitched, filtered, and thresholded to obtain a binary image of the whole implant that finally was dilated and outlined. The length of this outline was measured as the maximum possible BIC. The regions of coincidence between this line and the bone were measured as the real BIC.ResultsThe proposed methodology for BIC determination, based on SEM, which has a much higher resolution than optical microscopy, allows the acquisition of highly discriminative images with great contrast between implant and bone. The high resolution and high contrast in SEM images provide more accurate results than those obtained by classical methods. Furthermore, the methodology of image analysis described in this study delineates precisely and automatically the contour of the implant, which results in non‐biased measurements. The average percentage of BIC was 35%, ranging from 24.7 to 45.5%. These values were similar to the results documented in the literature for implants of similar roughness in animal models.ConclusionsA novel, non‐subjective, and systematic method for measuring BIC is described based on BS‐SEM images. The proposed methodology minimizes the shortcomings of the results obtained by previously described methods.
Results of a cosmetovigilance survey in The Netherlands
Authors: Salverda Joanne G. W. , Bragt Peter J. C. , de Wit‐Bos Lianne , Rustemeyer Thomas , Coenraads Pieter Jan , Tupker Ron. A. , Kunkeler Lia C. M. , Laheij‐de Boer Anna‐Marijke , Stenveld Harma J. , van Ginkel Cees J. W. , Kooi Myrna W. , Bourgeois François. C. , van Gorcum Teetske F. , van Engelen Jacqueline G. M. , van Dijk Remmelt , de Graaf Judith , Donker Gé A. , de Heer Cees , Bruynzeel Derk 
Published: February 2013

Background. Cosmetic products contribute considerably to the incidence of contact dermatitis. In response to a resolution of the Council of Europe, the National Institute for Public Health and the Environment (RIVM) in The Netherlands set up a pilot project to report undesirable effects attributed to cosmetic products.Objectives. To provide an overview of undesirable effects attributed to cosmetic products and to identify the ingredients involved. The information could contribute to the assessment of whether current EU legislation on cosmetics provides adequate protection.Patients/methods. General practitioners, dermatologists and consumers in The Netherlands completed questionnaires on reported undesirable effects of cosmetics. Dermatologists also carried out patch tests and, where necessary, tests with specific batch ingredients of the associated cosmetic product. A website and a public awareness campaign were launched to encourage consumers to report undesirable effects.Results. Between July 2009 and May 2011, the RIVM received more than 1600 reports. Severe undesirable effects were claimed in 1–4% of the cases. The most frequently reported cosmetic products were make‐up and moisturisers, and the most frequently identified allergens were isothiazolinones and fragrance ingredients. Three patients tested positive for co‐polymers/cross‐polymers.Conclusions. Further investigations are recommended on the prevalence of isothiazolinone‐induced allergic contact dermatitis and the allergenic potential of co‐polymers/cross‐polymers.
The acute effects of exercise on the microvascular volume of Achilles tendons in healthy young subjects
Authors: Pingel Jessica , Harrison Adrian , Suetta Charlotte , Simonsen Lene , Langberg Henning , Bülow Jens 
Published: February 2013

SummaryBackgroundReal‐time harmonic contrast‐enhanced ultrasound (CEU) is used in several diseases to visualize the microvascularization in various tissues, due to its high sensitivity.AimThe aim of the present study was to investigate whether CEU could be used to detect an increase in the microvascular volume (MV) in healthy tendon tissue in response to exercise comprising a 1‐h run.MethodsAfter a bolus injection of the ultrasound contrast SonoVue®, CEU measurements of (MV) in the Achilles tendon were taken prior to exercise, immediately after a 1‐h run, and 24 h after exercise in nine healthy young subjects (seven men and two women) mean age 31 ± 4 years. In addition, the effect of 15 min of arm cycling exercise on the flow within the Achilles tendon was tested in four athletes (mean age 33 ± 6 years) using the CEU method before and after exercise.ResultsThe present data show a significant increase in the (MV) of the Achilles tendon for all subjects following the run compared with before exercise. No significant change in (MV) was seen in the Achilles tendon after 15‐min arm cycling exercise (P = 0·96). This indicates that the increase in microvascular blood volume within the Achilles tendon in response to running is a local response.ConclusionThe present data reveal that real‐time harmonic CEU can be used to determine the MV of healthy Achilles tendons both at rest and after 1 h of running exercise.
Effects of mycophenolate mofetil introduction in liver transplant patients: results from an observational, non‐interventional, multicenter study (LOBSTER)
Authors: Schlitt Hans J. , Jonas Sven , Ganten Tom M. , Grannas Gerrit , Moench Christian , Rauchfuss Falk , Obed Aiman , Tisone Giuseppe , Pinna Antonio D. , Gerunda Giorgio E. , Beckebaum Susanne 
Published: February 2013

AbstractThe benefits of calcineurin inhibitor (CNI)‐sparing regimens on renal function following liver transplantation (LT) have been demonstrated in clinical studies. This observational study assessed the real‐life effects of mycophenolate mofetil (MMF) introduction in LT patients. Four hundred and ninety‐seven patients in whom MMF was introduced according to local standards or clinical considerations were entered. Patients were grouped by time between transplantation and start of MMF (start of study): Group A (n = 263): ≤6 d; Group B (n = 64): >6 d to ≤1 month; Group C (n = 74): >1 month to ≤1 yr; and Group D (n = 96): >1 yr. CNI sparing occurred in all groups, particularly in Groups C and D. Mean MMF doses at 12 months were 1202.7, 1363.5, 1504.7, and 1578.1 mg/d, respectively, in Groups A–D. At introduction of MMF, median glomerular filtration rate was 73.3, 81.7, 62.7, and 53.7 mL/min/1.73 m2 in Groups A–D. At 12 months, this decreased to 66 mL/min/1.73 m2 in Groups A and B, remained stable in Group C, and increased in Group D (64.8 mL/min/1.73 m2). Serious adverse drug reactions were lowest in Group D. In conclusion, MMF with a subsequent decrease in CNI was well tolerated and improved renal function even years after transplantation. A more forceful MMF dosing strategy with greater CNI sparing may further improve renal function.
Is income converging in China?
Authors: Su Chi‐Wei , Chang Hsu‐Ling 
Published: February 2013

AbstractThis study adopts a flexible Fourier unit‐root test proposed by Enders and Lee (2012) to revisit the tendency towards convergence in real per capita income among provinces after economic reform in China. When a data‐generating process is non‐linear, a Fourier series not only allows for the possibility of an unknown number of structural breaks with unknown forms but also allows for the use of a low‐frequency component to capture multiple changes. Contrary to what the linear statistics suggest, our results from a flexible unit‐root test indicate that China's eastern and western regions are converging to their own specific steady states.
Do educational methods affect students' ability to remove artificial carious dentine? A randomised controlled trial
Authors: Rosa Q. F. , Barcelos T. M. , Kaizer M. R. , Montagner A. F. , Sarkis‐Onofre R. , Masotti A. S. , Jardim P. S. , Pereira‐Cenci T. , Oliveira E. F. , Cenci M. S. 
Published: February 2013

AbstractThis trial aimed to evaluate the influence of two educational methods on students' ability to remove artificial carious dentine. Traditional lecture and lecture plus a live demonstration of artificial carious tissue removal were compared in a blind two‐parallel‐group design. Twenty‐six students were randomly divided into two groups, and their skills were evaluated according to the following criteria: time spent on the dentine excavation procedure (in min), students' perceived confidence in conducting the procedure (graded assessed on a scale from 0 to 10), and the outcome of artificial carious tissue removal, evaluated by measuring the residual dyed artificial carious dentine layer (in μm). Statistical analyses were carried out using a t‐test to compare the students' confidence and time spent on the procedure, and a two‐way ANOVA was used to compare residual artificial decayed dentine with educational methods and tooth region (incisal, medium, and cervical thirds) as factors. There were no differences between the methods regarding excavation time (P = 0.898) and students' confidence (P = 0.382). The residual artificial carious dentine results showed that the educational method (P < 0.001) and cavity region (P < 0.001) were statistically significant, as was their interaction (P = 0.040). The lecture plus live demonstration group presented the best results for artificial caries removal. Although there were no differences between the two groups for the cervical region, the best results for the lecture plus live demonstration group was in the other two‐thirds of the tooth.
The dependencies of fronto‐parietal BOLD responses evoked by covert visual search suggest eye‐centred coding
Authors: Atabaki A. , Dicke P.W. , Karnath H.‐O. , Thier P. 
Published: February 2013

AbstractVisual scenes explored covertly are initially represented in a retinal frame of reference (FOR). On the other hand, ‘later’ stages of the cortical network allocating spatial attention most probably use non‐retinal or non‐eye‐centred representations as they may ease the integration of different sensory modalities for the formation of supramodal representations of space. We tested if the cortical areas involved in shifting covert attention are based on eye‐centred or non‐eye‐centred coding by using functional magnetic resonance imaging. Subjects were scanned while detecting a target item (a regularly oriented ‘L’) amidst a set of distractors (rotated ‘L's). The array was centred either 5° right or left of the fixation point, independent of eye‐gaze orientation, the latter varied in three steps: straight relative to the head, 10° left or 10° right. A quantitative comparison of the blood‐oxygen‐level‐dependent (BOLD) responses for the three eye‐gaze orientations revealed stronger BOLD responses in the right intraparietal sulcus (IPS) and the right frontal eye field (FEF) for search in the contralateral (i.e. left) eye‐centred space, independent of whether the array was located in the right or left head‐centred hemispace. The left IPS showed the reverse pattern, i.e. an activation by search in the right eye‐centred hemispace. In other words, the IPS and the right FEF, members of the cortical network underlying covert search, operate in an eye‐centred FOR.