bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reconsideration of postoperative concurrent chemoradiotherapy with fluorouracil and cisplatin for uterine cervical cancer
Authors: Takekuma Munetaka , Kasamatsu Yuka , Kado Nobuhiro , Kuji Shiho , Tanaka Aki , Takahashi Nobutaka , Abe Masakazu , Hirashima Yasuyuki 
Published: July 2015

AbstractAimThe aim of this retrospective study was to analyze data for patients with stage IB–IIB uterine cervical cancer who were treated with concurrent chemoradiotherapy with fluorouracil (5‐FU) and cisplatin (CCRT‐FP) as postoperative adjuvant therapy and to re‐examine these issues and further treatment.MethodsPatients with high risk for recurrence underwent CCRT‐FP as postoperative adjuvant therapy. A total of 73 patients who met these criteria were included in this study. Data related to survival, toxicity, and treatment feasibility were analyzed, and the question of whether there were differences in survival and toxicity according to the number of dissected lymph nodes at surgery was evaluated.ResultsMedian patient age was 45 years (range, 24–67 years). Two‐thirds of patients had squamous cell histologic type, 41 patients (56.2%) had parametrial invasion, and 60 patients (82.2%) had lymph node metastases. Estimated 4‐year progression‐free survival, overall survival, and local control rates were 71.8%, 84.1%, and 88.5%, respectively. Sixteen patients (21.9%) had grade 3–4 neutropenia and one of them died of septic shock. Non‐hematological toxicities were also common: 13 (17.8%) experienced grade 3–4 nausea, and nine (12.3%) experienced grade 3–4 diarrhea. Ileus occurred in 17 patients (23.3%), and seven of them (9.6%) were not yet cured. One patient experienced gastrointestinal perforation.ConclusionsCCRT‐FP in the postoperative setting resulted in good survival outcome but toxicity remained problematic. Development of appropriate treatment for patients with high‐risk prognostic factors after radical hysterectomy and lymphadenectomy is required.
Influence of maternal body mass index on sonographic fetal weight estimation prior to scheduled delivery
Authors: Aksoy Hüseyin , Aksoy Ülkü , Karadağ Özge İdem , Yücel Burak , Aydın Turgut , Babayiğit Mustafa Alparslan 
Published: July 2015

AbstractAimTo investigate the possible effect of maternal obesity on the accuracy of sonographically estimated fetal weight in the third‐trimester shortly before induction of labor and to compare the accuracy of the estimation between normal weight, overweight, and class I, class II and class III obese groups.MethodsThis was a prospective study of singleton pregnancies with sonographic fetal weight estimation prior to scheduled delivery. Women were classified according to current body mass index (BMI) into five categories: normal (BMI 18.5–24.9 kg/m2, n = 41), overweight (BMI 25.0–29.9 kg/m2, n = 44), obese class I (BMI 30.0–34.9 kg/m2, n = 40), obese class II (BMI, 35.0–39.9 kg/m2, n = 38) and obese class III (BMI ≥ 40.0 kg/m2, n = 35). The estimated fetal weight was compared with the actual birthweight, and the difference between them was recorded as the error.ResultsMean absolute error of sonographic fetal weight estimation was 106.97 ± 80.83 g, 198.88 ± 124.32 g, 248.82 ± 122.75 g, 308.31 ± 138.97 g and 446.00 ± 151.46 g in the normal, overweight, obese class I, obese class II, and obese class III groups, respectively (P < 0.001). The corresponding mean absolute percentage errors were 3.51 ± 2.76, 6.37 ± 3.91, 7.93 ± 4.81, 9.87 ± 4.32 and 14.06 ± 5.83 (P < 0.001).ConclusionsMaternal obesity decreases the accuracy of sonographic fetal weight estimation. Clinicians should be aware of the limitations of sonographic fetal weight estimation, especially in obese patients.
Goal‐directed fluid therapy may improve hemodynamic stability in parturient women under combined spinal epidural anesthesia for cesarean section and newborn well‐being
Authors: Xiao Wei , Duan Qingfang , Zhao Lei , Chi Xinzuo , Wang Fengying , Ma Daqing , Wang Tianlong 
Published: July 2015

AbstractAimTo investigate whether goal‐directed fluid therapy (GDFT) with the LiDCOrapid system can reduce the incidence of maternal hypotension and improve neonatal outcome.MethodsOne hundred healthy term parturient women scheduled for elective cesarean section were recruited. After loading with 10 mL/kg Lactated Ringer's solution, parturient women were randomized to the GDFT and control group. In the GDFT group, individualized fluid therapy was implemented to optimize stroke volume, guided by the LiDCOrapid system. The control group received routine fluid therapy. Primary endpoints included onset of maternal hypotension, and vasopressor doses prior to delivery. The secondary endpoints included umbilical blood gas abnormalities and neonatal adverse events.ResultsIncidence of hypotension and mean phenylephrine dose administered prior to delivery were significantly higher in the control group than in the GDFT group (P < 0.01). There was no difference in Apgar score between the two groups. In the control group, mean umbilical artery and vein blood pH were significantly lower, corresponding to significantly higher incidences of neonatal hypercapnia and hypoxemia, compared with the GDFT group (P < 0.05).ConclusionsLiDCOrapid‐guided GDFT may provide benefit to healthy parturient women and their newborns.
Impaired incretin effect is an early sign of glucose dysmetabolism in nondiabetic patients with psoriasis
Authors: Gyldenløve M. , Vilsbøll T. , Zachariae C. , Holst J. J. , Knop F. K. , Skov L. 
Published: July 2015

AbstractBackgroundPatients with psoriasis have an increased risk of type 2 diabetes. The gastrointestinal system plays a major role in normal glucose metabolism, and in healthy individuals, postprandial insulin secretion is largely mediated by the gut incretin hormones. This potentiation is termed the incretin effect and is reduced in type 2 diabetes. The impact of psoriasis on gastrointestinal factors involved in glucose metabolism has not previously been examined.ObjectiveTo investigate whether the incretin effect, gastrointestinal‐mediated glucose disposal (GIGD) and/or secretion of glucagon and gut incretin hormones are impaired in normal glucose‐tolerant patients with psoriasis.MethodsOral glucose tolerance tests and intravenous isoglycaemic glucose infusions were performed in 12 patients with moderate‐to‐severe psoriasis and 12 healthy matched control subjects.ResultsIn patients with psoriasis, the incretin effect (39% vs. 57%, P = 0.02) and GIGD (53% vs. 61%, P = 0.04) were significantly reduced compared to control subjects. In addition, patients were glucose intolerant and showed exaggerated glucose‐dependent insulinotropic polypeptide responses.ConclusionThese novel findings support the notion that psoriasis is a prediabetic condition and suggest that gastrointestinal‐related mechanisms are involved in the increased susceptibility to type 2 diabetes in patients with psoriasis.
Understanding the Social Role of Entrepreneurship
Authors: Zahra Shaker A. , Wright Mike 
Published: July 2015

AbstractThere is a need to rethink and redefine the social value added of entrepreneurial activities to society. In this paper we develop five pillars on which the evolving social role of entrepreneurship can rest and have its impact: (1) connecting entrepreneurial activities to other societal efforts aimed at improving the quality of life, achieving progress, and enriching human existence, (2) identifying ways to reduce the dysfunctional effects of entrepreneurial activities on stakeholders, (3) redefining the scope of entrepreneurial activities as a scholarly arena, (4) recognizing entrepreneurship's social multiplier, and (5) pursuing blended value at the organizational level, centring on balancing the creation of financial, social and environmental wealth. In a final section we discuss implications for practices and for further research.
Presurgical fMRI and DTI for the Prediction of Perioperative Motor and Language Deficits in Primary or Metastatic Brain Lesions
Authors: Bailey Paul D. , Zacà Domenico , Basha Mahmud Mossa , Agarwal Shruti , Gujar Sachin K. , Sair Haris I. , Eng John , Pillai Jay J. 
Published: July 2015

ABSTRACTBACKGROUND AND PURPOSETo determine whether lesion to activation distance (LAD) on presurgical blood‐oxygen‐level‐dependent functional magnetic resonance imaging (fMRI) and degree of white matter involvement by primary or metastatic brain lesions predict perioperative motor and language deficits.METHODSWe retrospectively evaluated 76 patients with intra‐axial brain lesions referred for presurgical fMRI and diffusion tensor imaging (DTI). We measured expressive, receptive, global language and motor LAD and assessed degree of involvement of the corticospinal tract (CST) and the superior longitudinal fasciculus (SLF). We performed a Wilcoxon rank‐sum test to determine whether the LAD and the degree of CST/SLF involvement were statistically significantly different between patients with and without preoperative or postoperative neurological deficits.RESULTSIn preoperatively symptomatic patients, motor and expressive language LAD were significantly lower (z = –3.78, P = .0002, and z = –2.51, P = .01, respectively) than in asymptomatic patients. No significant difference was noted in LAD between postoperative symptomatic and asymptomatic patients, except for a trend level effect for motor LAD (P = .07). The degree of CST involvement was significantly different between symptomatic and asymptomatic patients (z = 3.40, P = .0007 and z = 2.97, P = .003, respectively, for pre‐ and postoperative motor deficits).The degree of SLF involvement was significantly different between preoperatively (but not postoperatively) symptomatic and asymptomatic patients (z = 2.85, P = .004).CONCLUSIONPresurgical motor and expressive language LAD as well as degree of tract involvement on DTI are predictive of preoperative but not postoperative deficits, except for CST DTI and (trend level) motor LAD; inability of language LAD to predict postoperative deficits suggests that preoperative fMRI is valuable to neurosurgeons in avoiding resection of eloquent cortex.
The job crafting intervention: Effects on job resources, self‐efficacy, and affective well‐being
Authors: van den Heuvel Machteld , Demerouti Evangelia , Peeters Maria C. W. 
Published: July 2015

This quasi‐experimental field study examines the effects of an intervention designed to boost job resources, affective well‐being, and self‐efficacy via job crafting behaviour. Employees (n = 39) in a Dutch police district received a 1‐day training, after which they worked towards self‐set crafting goals for a period of 4 weeks. The intervention concluded with a half‐day reflection session in which learning points were consolidated. Participating in the intervention was expected to boost job resources such as opportunities for development and leader–member exchange (LMX), as well as enhance self‐efficacy and positive affect and to reduce negative affect. Repeated measures ANOVAs did not yield significant results. However, pre–post comparison tests showed that the intervention group reported less negative affect as well as increased self‐efficacy, developmental opportunities and LMX in the post‐measure compared with the pre‐measure. The control group (n = 47) showed no significant changes from pre‐ to post‐measure. In addition, in weeks during which individuals sought more resources, they also reported more developmental opportunities, LMX, and positive affect. Although further research is needed, the job crafting intervention seems to have potential to enable employees to proactively build a motivating work environment and to improve their own well‐being.Practitioner points

Job crafting is proactive behaviour at work that allows employees to redesign their own jobs.

In weeks when employees actively focus on building job resources, they also find more job resources and experience more positive affect.

The job crafting intervention may help employees to build resources and affective well‐being at work.
Burning With Envy? Dispositional and Situational Influences on Envy in Grandiose and Vulnerable Narcissism
Authors: Neufeld Darren C. , Johnson Edward A. 
Published: July 2015

AbstractResearch on narcissism and envy suggests a variable relationship that may reflect differences between how vulnerable and grandiose narcissism relate to precursors of envy. Accordingly, we proposed a model in which dispositional envy and relative deprivation differentially mediate envy's association with narcissistic vulnerability, grandiosity, and entitlement. To test the model, 330 young adults completed dispositional measures of narcissism, entitlement, and envy; one week later, participants reported on deprivation and envy feelings toward a peer who outperformed others on an intelligence test for a cash prize (Study 1) or earned higher monetary payouts in a betting game (Study 2). In both studies, structural equation modeling broadly supported the proposed model. Vulnerable narcissism robustly predicted episodic envy via dispositional envy. Entitlement—a narcissistic facet common to grandiosity and vulnerability—was a significant indirect predictor via relative deprivation. Study 2 also found that (a) the grandiose leadership/authority facet indirectly curbed envy feelings via dispositional envy, and (b) episodic envy contributed to schadenfreude feelings, which promoted efforts to sabotage a successful rival. Whereas vulnerable narcissists appear dispositionally envy‐prone, grandiose narcissists may be dispositionally protected. Both, however, are susceptible to envy through entitlement when relative deprivation is encountered.
Harsh Parenting, Deviant Peers, Adolescent Risky Behavior: Understanding the Meditational Effect of Attitudes and Intentions
Authors: Neppl Tricia K. , Dhalewadikar Jui , Lohman Brenda J. 
Published: July 2015

Although research supports the influence of parents and peers on adolescent risky behavior, less is known about mechanisms proposed to explain this relation. This study examined the influence of adolescent attitudes and intentions about such behaviors. Prospective, longitudinal data came from rural youth who participated throughout adolescence (n = 451). Observed harsh parenting and relationship with deviant peers was assessed in early adolescence, attitudes and intentions were measured during middle adolescence, and risky behavior was assessed in late adolescence. Results indicated that parenting and deviant peers was related to engagement in tobacco use, alcohol use, and risky sexual behaviors. Moreover, attitudes and intentions mediated this relationship even after parent use and adolescent early involvement in these behaviors were taken into account.
Diagnosis and management of paediatric concussion
Authors: Bressan Silvia , Babl Franz E 
Published: July 2015

AbstractHeightened recognition of concussions and concerns about their sequelae in children has become an increasing community and public health concern. Biomarkers and clinical tests are being explored, but the diagnosis of concussion in the emergency department continues to be based on clinical signs and symptoms. While the majority of children go on to recover from post‐concussive symptoms within 2 weeks, it is unclear which patients with concussion will go on to develop short‐ or long‐term sequelae. A number of more or less evidence‐based guidelines have become available which seek to guide clinicians on how to manage children post‐concussion. In general, care after the emergency department is focused on reducing the risk of re‐injury and rest until cerebral recovery with a graduated return to school and then play.
Estimation of the standardized ileal digestible lysine requirement for primiparous pregnant sows
Authors: Shi M. , Shi C. X. , Li Y. K. , Li D. F. , Wang F. L. 
Published: July 2015

SummaryThis experiment was conducted to determine the optimal standardized ileal digestible lysine (SID Lys) level in diets fed to primiparous sows during gestation. A total of 150 (Landrace × Large White) crossbred gilts (weighing 149.9 ± 3.1 kg) were fed gestation diets (12.55 MJ of ME/kg) containing SID Lys levels of 0.43, 0.52, 0.60, 0.70 or 0.80% respectively. Gilts were fed 2.0 kg/day from day 1 to 80 and 3.0 kg/day from day 80 to 110 of gestation respectively. Gilts were allocated to treatments based on their body weight on the day of breeding. Weight gain from day 80 to 110 increased with increasing dietary SID Lys levels (p = 0.044). Fitted broken‐line (p = 0.031) and quadratic plot (p = 0.047) analysis of body weight gain indicated that the optimal SID Lys level for primiparous sows was 0.70 and 0.69% respectively. During gestation, neither backfat thickness nor loin eye area was affected by dietary SID Lys level. Increasing dietary Lys had no effect on the litter size at birth or pigs born alive per litter. Litter weight at birth was not affected by dietary SID Lys level. The litter weight variation at birth quadratically decreased with increasing dietary SID Lys (p = 0.021) and was minimized at 0.70% dietary SID Lys. Gilts fed the 0.70% SID Lys diet had the highest dry matter (p = 0.031) and protein (p = 0.044) content in colostrum. On day 110 of gestation, gilts fed the 0.70% SID Lys diet tended to have the highest serum prolactin (p = 0.085) and serum insulin (p = 0.074) levels. The data demonstrate that the optimal dietary SID Lys was 0.70% for pregnant gilts, which is similar to the recommendation of 0.69% that was estimated by the NRC (2012).
Using phylogenomics to resolve mega‐families: An example from Compositae
Authors: Mandel Jennifer R. , Dikow Rebecca B. , Funk Vicki A. 
Published: July 2015

AbstractNext‐generation sequencing and phylogenomics hold great promise for elucidating complex relationships among large plant families. Here, we performed targeted capture of low copy sequences followed by next‐generation sequencing on the Illumina platform in the large and diverse angiosperm family Compositae (Asteraceae). The family is monophyletic, based on morphology and molecular data, yet many areas of the phylogeny have unresolved polytomies and interpreting phylogenetic patterns has been historically difficult. In order to outline a method and provide a framework and for future phylogenetic studies in the Compositae, we sequenced 23 taxa from across the family in which the relationships were well established as well as a member of the sister family Calyceraceae. We generated nuclear data from 795 loci and assembled chloroplast genomes from off‐target capture reads enabling the comparison of nuclear and chloroplast genomes for phylogenetic analyses. We also analyzed multi‐copy nuclear genes in our data set using a clustering method during orthology detection, and we applied a network approach to these clusters—analyzing all related locus copies. Using these data, we produced hypotheses of phylogenetic relationships employing both a conservative (restricted to only loci with one copy per targeted locus) and a multigene approach (including all copies per targeted locus). The methods and bioinformatics workflow presented here provide a solid foundation for future work aimed at understanding gene family evolution in the Compositae as well as providing a model for phylogenomic analyses in other plant mega‐families.
Sexual Dysfunctional Beliefs Questionnaire (SDBQ): Translation and Psychometric Properties of the Iranian Version
Authors: Abdolmanafi Atefe , Azadfallah Parviz , Fata Ladan , Roosta Mohsen , Peixoto Maria Manuela , Nobre Pedro 
Published: July 2015

ABSTRACT

Introduction
The sexual dysfunctional beliefs questionnaire (SDBQ) is a validated measure for assessing dysfunctional sexual beliefs.

Aims
The aim of this study was to translate and validate the SDBQ to Iranian context.

Methods
In order to translate the questionnaire from English into Persian, a forward–backward procedure was applied. After linguistic validation, the psychometric properties of the Iranian version were assessed for both men and women. A total of 387 participants (226 women and 161 men) completed the SDBQ.

Main Outcome Measures
A principle component analysis with varimax rotation was performed for both the male and female samples. Reliability was evaluated by calculating Cronbach's alpha (internal consistency) and test–retest coefficients (intraclass correlation coefficient).

Results
The results from the principle component analysis identified six factors in the female version: sexual conservatism and female sexual passivity, beliefs about masturbation, body image beliefs, sexual desire and pleasure as a sin, age-related beliefs, and denying affection primacy. In the male version six factors were also identified: sex as an abuse of men's power, beliefs related to women's satisfaction, sexual conservatism, female sexual power, “macho” beliefs, and restrictive attitudes toward sex. Findings support the original six-factor solution for the male sample. For the female sample, although a six-factor solution was found, original motherhood-related beliefs were included in the sexual conservatism and female sexual passivity factor, and a new dimension has emerged, related to masturbation beliefs. Additionally, results indicated that the SDBQ had good internal consistency and test–retest reliability in both male and female versions.

Conclusion
Current findings support the reliability and validity of the SDBQ in an Iranian sample and suggest its applicability to assess sexual beliefs in both clinical samples and the general population in Iran.
Approach and Avoidance Sexual Goals in Couples with Provoked Vestibulodynia: Associations with Sexual, Relational, and Psychological Well-Being
Authors: Rosen Natalie O. , Muise Amy , Bergeron Sophie , Impett Emily A. , Boudreau Gillian K. 
Published: July 2015

ABSTRACT

Introduction
Provoked vestibulodynia (PVD) is a prevalent vulvovaginal pain condition that is triggered primarily during sexual intercourse. PVD adversely impacts women's and their partners' sexual relationship and psychological well-being. Over 80% of women with PVD continue to have intercourse, possibly because of sexual goals that include wanting to pursue desirable outcomes (i.e., approach goals; such as a desire to maintain intimacy) and avoid negative outcomes (i.e., avoidance goals; such as avoiding a partner's disappointment).

Aim
The aim of this study was to investigate associations between approach and avoidance sexual goals and women's pain, as well as the sexual, relational, and psychological well-being of affected couples.

Methods
Women with PVD (N = 107) and their partners completed measures of sexual goals, sexual satisfaction, relationship satisfaction, and depression. Women also completed measures of pain during intercourse and sexual functioning.

Main Outcome Measures
(1) Global Measure of Sexual Satisfaction Scale, (2) Dyadic Adjustment Scale—Revised or the Couple Satisfaction Index, (3) Beck Depression Inventory-II, (4) numerical rating scale of pain during intercourse, and (5) Female Sexual Function Index.

Results
When women reported higher avoidance sexual goals, they reported lower sexual and relationship satisfaction, and higher levels of depressive symptoms. In addition, when partners of women reported higher avoidance sexual goals, they reported lower relationship satisfaction. When women reported higher approach sexual goals, they also reported higher sexual and relationship satisfaction.

Conclusions
Targeting approach and avoidance sexual goals could enhance the quality and efficacy of psychological couple interventions for women with PVD and their partners.