bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biogeographic history and high-elevation adaptations inferred from the mitochondrial genome of Glyptosternoid fishes (Sisoridae, Siluriformes) from the southeastern Tibetan Plateau
Authors: Ma Xiuhui , Kang Jingliang , Chen Weitao , Zhou Chuanjiang , He Shunping 
Published: October 2015

Abstract
Background
The distribution of the Chinese Glyptosternoid catfish is limited to the rivers of the Tibetan Plateau and peripheral regions, especially the drainage areas of southeastern Tibet. Therefore, Glyptosternoid fishes are ideal for reconstructing the geological history of the southeastern Tibet drainage patterns and mitochondrial genetic adaptions to high elevations.

Results
Our phylogenetic results support the monophyly of the Sisoridae and the Glyptosternoid fishes. The reconstructed ancestral geographical distribution suggests that the ancestral Glyptosternoids was widely distributed throughout the Brahmaputra drainage in the eastern Himalayas and Tibetan area during the Late Miocene (c. 5.5 Ma). We found that the Glyptosternoid fishes lineage had a higher ratio of nonsynonymous to synonymous substitutions than those found in non-Glyptosternoids. In addition, ωpss was estimated to be 10.73, which is significantly higher than 1 (p-value 0.0002), in COX1, which indicates positive selection in the common ancestral branch of Glyptosternoid fishes in China. We also found other signatures of positive selection in the branch of specialized species. These results imply mitochondrial genetic adaptation to high elevations in the Glyptosternoids.

Conclusions
We reconstructed a possible scenario for the southeastern Tibetan drainage patterns based on the adaptive geographical distribution of the Chinese Glyptosternoids in this drainage. The Glyptosternoids may have experienced accelerated evolutionary rates in mitochondrial genes that were driven by positive selection to better adapt to the high-elevation environment of the Tibetan Plateau.
Surgeon-performed ultrasound guided fine-needle aspirate biopsy with report of learning curve; a consecutive case-series study
Authors: Fernandes Vinay T. , De Santis Robert J. , Enepekides Danny J. , Higgins Kevin M. 
Published: October 2015

Background Fine-needle aspiration biopsy has become the standard of care for the evaluation of thyroid nodules. More recently, the use of ultrasound guided fine-needle aspiration biopsy (UG-FNAB) has improved adequacy of sampling. Now there has been improved access to UG-FNAB as ultrasound technology has become more accessible. Here we review the adequacy rate and learning curve of a single surgeon starting at the adoption of UG-FNAB into surgical practice. Methods UG-FNABs performed at Sunnybrook Health Sciences Centre from 2010 to 2015 were reviewed retrospectively. Nodule characteristics were recorded along with cytopathology and final pathology reports. Chi-square analysis, followed by the reporting of odds ratios with confidence intervals, were used to assess the statistical significance and frequencies, respectively, of nodule characteristics amongst both diagnostic and non-diagnostic samples. A multiple regression analysis was conducted to determine if any nodule characteristic were predictive of adequacy of UG-FNABs. The learning curve was assessed by calculating the eventual adequacy rates across each year, and its statistical significance was measured using Fischer's Exact Test. Results In total 423 biopsies were reviewed in 289 patients. The average nodule size was 23.05 mm. When examining if each patient eventually received a diagnostic UG-FNAB, regardless of the number attempts, adequacy was seen to increase from 70.8 % in 2010 to, 81.0 % in 2011, 90.3 % in 2012, 85.7 % in 2013, 89.7 % in 2014, and 94.3 % in 2015 (Fischer's Exact Test, p = 0.049). Cystic (χ2 = 19.70, p <0.001) nodules were found to yield higher rates of non-diagnostic samples, and their absence are predictive of obtaining an adequate biopsy as seen in a multiple regression analysis ( p < 0.001) Adequacy of repeat biopsies following an initial non-diagnostic sample was 75.0 %. Conclusions Surgeons are capable of performing UG-FNAB with a learning curve noted to achieve standard adequacy rates. Cystic nodules are shown to yield more non-diagnostic samples in the surgeon's office.
Comparison of sexual function and quality of life after pelvic trauma with and without Angioembolization
Authors: Goussous Naeem , Sawyer Mark D. , Wuersmer Lisa-Ann , Huebner Marianne , Osborn Molly L. , Zielinski Martin D. 
Published: October 2015

AbstractBackgroundThe aim is to study the safety of Angioembolization on long-term sexual function and quality of life.MethodsIRB approval was gained to review the prospectively collected trauma database as well as prospective questionnaires of patients at least 1 year out from pelvic fractures that occurred between 1996 and 2009. Surveys included the SF36v2, Female Sexual Function Index and the International Index of Erectile Function. Values for each domain were compared between patients treated with AE and 2:1 case-matched control patients as well as between the national norms. Values are presented as percentages or means with 95 % CI. P &lt; 0.05 was considered statistically significant.ResultsThirty Seven cases and 74 matched controls were identified. 42 patients completed the survey. There were 13 cases (12 males), and 29 controls (22 males). There was a higher ISS (Injury Severity Score) (32 vs 27; p = 0.048) in the cases, but no difference in pelvic AIS (Abbreviated Injury Severity Score) (3 vs 3). Both groups scored similarly in the SF36 in all domains, but the entire cohort scored lower than the national norms in the physical functioning (41.9 (37.8–46.0) vs50), role physical (40.9 (36.2–45.7) vs50), body pain 43.8 (40.7–46.9) vs50), role emotional 46.3 (42.8–49.8) vs50), and physical composite score (42.1 (38.0–46.3) vs50). All domains of the sexual function in both questionnaires showed significant impairment in our cohort compared with norms. Male cases had similar scores to the controls.ConclusionPelvic fractures portend a worse long-term QOL and sexual function than the general population. AE, however, does not have an additive affect to these indices.
In Plain View of the Catholic Faithful: Church-Peasant Conflict in the Peruvian Andes, 1963–1980
Authors: La Serna Miguel 
Published: October 2015

Abstract
This essay chronicles the mounting conflict between indigenous peasants and Catholic Church authorities in mid-twentieth-century Chuschi, an Andean community in Ayacucho, Peru. What began as a local conflict between villagers and individual priests developed into an open rebellion against the Roman Catholic Archdiocese of Ayacucho. Taking advantage of Peru's changing social and political landscape, as well as a vocational crisis within the church, Chuschinos ultimately succeeded in ousting the church from the community, thus contributing to the Catholic Church's final collapse in the Ayacuchan countryside.
“I Do What I Please, but Even So, I See a Psychologist”
Authors: Meler Tal 
Published: October 2015

AbstractDivorce, separation, and widowhood produce great psychological stress for Palestinian women in Israel. Very often family support is a set of demands seeking to regulate and reshape their conduct. This article is based on a study conducted between 2007 and 2011 with twenty-four divorced, separated, and widowed Palestinian single mothers in Israel. In contrast to claims in most existing scholarship, all of the women turned to nonfamilial sources of support to deal with family and community regulation, restrictions, and stigmatization and to acquire resources. Level of surveillance and regulation was most highly associated with socioeconomic class. The poorer the women, the fewer their choices and the less freedom they had to determine their lives and their children’s lives. The women interviewed disproportionately reported turning to outsiders, such as psychologists, spiritualists, and feminist activists, for “expressive” support.
Patterns of Performance on the Modified Cued Recall Test in Spanish Adults With Down Syndrome With and Without Dementia
Authors: Benejam Bessy , Fortea Juan , Molina-López Rafael , Videla Sebastià 
Published: October 2015

AbstractThe assessment of memory decline in people with intellectual disability (ID) is more difficult than in the general population, due to a lack of appropriate instruments and to preexisting cognitive impairment. The aim of this study was to describe performance of healthy adults with Down syndrome (healthy-DS; prospectively cohort) on a Spanish version of the modified Cued Recall Test (mCRT). We also recruited retrospectively a cohort of DS subjects with Dementia of the Alzheimer's Type (DS-DAT). Healthy-DS obtained higher scores on free recall and total score than DS-DAT. Age was the main factor associated with decreasing mCRT scores. The mCRT was useful in DS subjects with ID at the upper end of the spectrum or ID in the middle range of the spectrum, and discriminated well between DS subjects with and without DAT.
The Relative Risk of Divorce in Parents of Children With Developmental Disabilities:Impacts of Lifelong Parenting
Authors: Namkung Eun Ha , Song Jieun , Greenberg Jan S. , Mailick Marsha R. , Floyd Frank J. 
Published: October 2015

Abstract
We prospectively examined the risk of divorce in 190 parents of children with developmental disabilities compared to 7,251 parents of children without disabilities based on a random sample drawn from the community and followed longitudinally for over 50 years. A significant interaction between the parental group status and number of children was found: In the comparison group, having a larger number of children was related to an increased risk of divorce, whereas the number of children did not increase divorce risk among parents of children with developmental disabilities.
Shear Lag Effect In The Numerical Experiment
Authors: Szumigała M. , Ciesielczyk K. 
Published: October 2015

AbstractThe standard PN-EN 1993-1-5: 2008 (Eurocode 3) compared with the standard (PN-B-03200: 1990) used previously in Poland, introduces extended rules referring to the computations of the bearing capacity of the plated structural elements including the shear lag effect. The stress distribution in the width flanges is variable. Therefore in the case of the beam with the shear lag effect cannot be calculated by the classic beam theory.In this article a comparison of the results of the calculations of forces distribution, stresses and displacement according to the rule presented in PN-EN 1993 and results of the numerical computations for 3D model (using finite element method) is presented. The elastic shear lag effects, the elastic shear lag effects including effects of the plate buckling and the elastic-plastic shear lag effects including the local instabilities were analysed. The calculations were performed for beams with a small and a large span and an influence of stiffeners was analysed.
Technology Selection For Construction Project, With The Use Of Fuzzy Preference Relation
Authors: Ibadov N. , Rosłon J. 
Published: October 2015

AbstractArticle deals with the problem of technology selection for construction project. Three criteria were proposed: cost, time and technological complexity. To solve the problem, fuzzy preference relations were used. Authors present an algorithm supporting multi-criteria decision-making process. The algorithm creates fuzzy preference relations on the basis of the fuzzy comparison: “xi is better than xj”. Then, with the use of criteria weights it creates general fuzzy preference relation, finds all non-dominated (admissible) alternatives and the best one among them. The algorithm consists of 7 steps. Authors show application of the proposed algorithm - example calculations.
Laboratory testing requirements for diagnosis and follow-up of multiple myeloma and related plasma cell dyscrasias
Authors: Willrich Maria A.V. , Katzmann Jerry A. 
Published: October 2015

AbstractMonoclonal immunoglobulins are markers of plasma cell proliferative diseases and have been described as the first (and perhaps best) serological tumor marker. The unique structure of each monoclonal protein makes them highly specific for each plasma cell clone. The difficulties of using monoclonal proteins for diagnosing and monitoring multiple myeloma, however, stem from the diverse disease presentations and broad range of serum protein concentrations and molecular weights. Because of these challenges, no single test can confidently diagnose or monitor all patients. Panels of tests have been recommended for sensitivity and efficiency. In this review we discuss the various disease presentations and the use of various tests such as protein electrophoresis and immunofixation electrophoresis as well as immunoglobulin quantitation, free light chain quantitation, and heavy-light chain quantitation by immuno-nephelometry. The choice of tests for inclusion in diagnostic and monitoring panels may need to be tailored to each patient, and examples are provided. The panel currently recommended for diagnostic screening is serum protein electrophoresis, immunofixation electrophoresis, and free light chain quantitation.
Heparinate but not serum tubes are susceptible to hemolysis by pneumatic tube transportation
Authors: Pasqualetti Sara , Szőke Dominika , Panteghini Mauro 
Published: October 2015

AbstractBackground:Pneumatic tube transportation (PTT) may induce hemolysis (H) in blood samples. We aimed to compare the H degree before and after PTT implementation in our hospital.Methods:Hemolysis indices (HI) for all lithium-heparin plasma samples (P) drawn by the Emergency Department in 2-month periods were retrospectively collected and pre- (n=3579) and post-PTT (n=3469) results compared. The impact of PTT introduction was investigated on LDH [HI threshold (HIt), 25], conjugated bilirubin (cBIL) (HIt, 30), K (HIt, 100) and ALT (HIt, 125). In addition, HI retrieved for P and paired serum samples collected in silica clot activator tubes (S) from the same venipuncture were compared in pre- (n=501) and post-PTT (n=509) periods.Results:Median (5–95th percentile) HI in P was significantly higher in post-PTT period [7 (0–112) vs. 6 (0–82), p<0.001]. Results reported as ‘Hemolysis’ in P increased from 6.6% in pre-PTT to 9.4% in post-PTT (p<0.001). Investigated tests gave the following rejection rates (pre-PTT vs. post-PTT): LDH, 13.4% vs. 18.8%, p<0.001; cBIL, 9.4% vs. 27.0%, p<0.05; K, 3.7% vs. 5.6%, p<0.001; ALT, 2.9% vs. 4.4%, p<0.01. The slightly higher susceptibility to H of S compared to paired P found in the pre-PTT [9 (1–64) vs. 6 (0–85)] was not confirmed in the post-PTT period [7 (0–90) vs. 8 (1–72)], in which median HI in S was significantly lower (p<0.001) than in pre-PTT.Conclusions:In our setting PTT promotes H in P, increasing the rate of rejected tests. The use of S appears to protect against the hemolysing effect of PTT.
Crystalluria
Authors: Daudon Michel , Frochot Vincent 
Published: October 2015

AbstractCrystalluria is a marker of urine supersaturation with substances deriving from metabolic disorders, inherited diseases or drugs. The investigation of crystalluria must be done according to a protocol which includes the delivery to the laboratory of a proper urine sample, the use of a microscope equipped with polarized light, the accurate knowledge of urine pH, and a comprehensive examination of the crystals, which is based on their identification, quantification and size measurement. For unusual crystals, infrared spectroscopy may also be needed. The main urinary crystalline categories include: calcium oxalates, calcium phosphates, uric acids and urates, struvite, aminoacids (cystine), purines (2,8-dihydroxyadenine and xanthine) and drugs (e.g. sulfamethoxazole, amoxycillin, ceftriaxone, atazanavir). The investigation of crystalluria is a cheap and valuable tool for the detection and the monitoring of inherited and acquired diseases associated with urinary stone formation or renal function impairment – either acute or chronic – due to intrarenal crystal precipitation.
The roles of leptin and adiponectin at the fetal-maternal interface in humans
Authors: Dos Santos Esther , Duval Fabien , Vialard François , Dieudonné Marie-Noëlle 
Published: October 2015

Abstract
Infertility now affects one in seven couples, and the prevalence of this condition continues to increase. Ovulatory defects and unknown causes account for more than half of the cases of infertility. It has been postulated that a significant proportion of these cases are directly or indirectly related to obesity, since the presence of excess adipose tissue has a variety of effects on reproductive function. Here, we review on the effects of the two major adipokines (leptin and adiponectin) on fertility, with a focus on the first steps in embryo implantation and the key components of fetal-maternal interface (the placenta and the endometrium). These adipokines are reportedly involved in the regulation of cell proliferation and differentiation, and as such affect local angiogenesis, immune tolerance and inflammatory processes in placental and endometrial tissues. In placental cells, leptin and adiponectin also modulate trophoblast invasiveness and the nutrient supply. These observations strongly suggest by interfering with the placenta and endometrium, adipokines can create a favorable environment for embryo implantation and have a key role in fetal-maternal metabolism, fetal-maternal communication, and gestation. Given that reproductive functions are tightly coupled to the energy balance, metabolic abnormalities may lead to the development of complications of pregnancy and changes in fetal growth. In this context, we suggest that the leptin/adiponectin ratio may be a clinically valuable marker for detecting a number of pathologies in pregnancy.
Serum steroids remain within the same normal postmenopausal values during 12-month intravaginal 0.50% DHEA
Authors: Ke Yuyong , Gonthier Renaud , Simard Jean-Nicolas , Archer David , Lavoie Lyne , Martel Céline , Vaillancourt Mario , Labrie Fernand 
Published: October 2015

Abstract

Objective: Analyze the serum levels of DHEA (prasterone) and its metabolites after daily intravaginal 0.50% (6.5 mg) DHEA in postmenopausal women with vulvovaginal atrophy (VVA).

Methods: Serum samples were obtained at baseline and after 12, 26 and 52 weeks of treatment. The serum levels of DHEA, DHEA-sulfate (DHEA-S), androstene-3β, 17β-diol (5-diol), androstenedione (4-dione), testosterone, dihydrotestosterone (DHT), estrone (E1), estradiol (E2), E1-sulfate (E1-S), androsterone glucuronide (ADT-G) and androstane-3α,17β-diol 17-glucuronide (3α-diol-17G) were measured by validated liquid chromatography-tandem mass spectrometry.

Results: A total of 435 women were exposed for 52 weeks. All serum steroids remained within normal values with no significant differences between lengths of treatment. For the most relevant estrogen-related compounds, namely E1, E2, and E1-S, a reliable marker of total estrogen exposure, the values in the DHEA-treated group at 52 weeks were –3.4%, –9.1% and +1.8%, respectively, compared to the normal postmenopausal values, thus clearly confirming the absence of significant systemic estrogen exposure.

Conclusion: While confirming that all serum sex steroids originating exclusively from DHEA after menopause are maintained within the normal postmenopausal values, the present data show that the dose of intravaginal DHEA used is free from systemic exposure with no detectable change in metabolism up to 52 weeks of treatment.
Unbiased Estimation of the Average Treatment Effect in Cluster-Randomized Experiments
Authors: Middleton Joel A. , Aronow Peter M. 
Published: October 2015

AbstractMany estimators of the average treatment effect, including the difference-in-means, may be biased when clusters of units are allocated to treatment. This bias remains even when the number of units within each cluster grows asymptotically large. In this paper, we propose simple, unbiased, location-invariant, and covariate-adjusted estimators of the average treatment effect in experiments with random allocation of clusters, along with associated variance estimators. We then analyze a cluster-randomized field experiment on voter mobilization in the US, demonstrating that the proposed estimators have precision that is comparable, if not superior, to that of existing, biased estimators of the average treatment effect.
Multiphase flow metering with nuclear magnetic resonance
Authors: Bilgic Attila M. , Kunze Johannes W. , Stegemann Volker , Hogendoorn Jankees , Cerioni Lucas , Zoeteweij Marco 
Published: October 2015

Abstract
The measurement of fluids in the oil and gas industry requires
a robust measurement of multiphase flows. Magnetic resonance as
a measurement principle has multiple advantages over existing
technologies (one single measurement principle, measurement performed
from outside the pipe with no intruding sensors, full bore design,
suited for producing wells and high sensitivity at high water liquid
ratios). A magnetic resonance based multiphase flow meter which is
capable of producing an image of the spatial distribution of
a multiphase flow has been developed. This article describes the
principles of magnetic resonance. Afterwards details of the technical
implementation and the method by which the system determines
multiphase flow composition are explained.
Adaptation of Saccades and Perceived Size after Trans-Saccadic Changes of Object Size
Authors: Bosco Annalisa , Lappe Markus , Fattori Patrizia 
Published: October 2015

When saccadic eye movements consistently fail to land on the intended target, saccade accuracy is maintained by gradually adapting the amplitude of successive saccades to the same target. Such saccadic adaptation is usually induced by systematically displacing a small visual target during the execution of the saccade. However, saccades are normally performed to extended objects. Here we report changes in saccade amplitude when the size of a target object is systematically changed during a saccade. Moreover, we find that this manipulation also affected the visual perception of the size of that object. Human subjects were tested in shortening and lengthening adaptation where they had to make saccades to targets of different sizes, which were each shortened or lengthened during saccade execution, respectively. In both experiments, a preadaptation and postadaptation phase required manually indicating the horizontal size of each target by grip aperture and, in a further experiment, a verbal size report. We evaluated the effect of change in visual perception on saccade and on the two modalities of judgment. We observed that (1) saccadic adaptation can be induced by modifying target object size and (2) this gradual change in saccade amplitude in the direction of the object size change evokes a concomitant change in perceived object size. These findings suggest that size is a relevant signal for saccadic system and its trans-saccadic manipulation entails considerable changes at multiple levels of sensorimotor performance.SIGNIFICANCE STATEMENTAcross a saccade to an object the visual system receives two views of that object, a presaccadic peripheral view and a postsaccadic foveal view. We show that manipulation of the size of the object after the saccade modifies presaccadic size perception and motor control. Saccade amplitudes become smaller when the postsaccadic object is smaller and perceived size estimates become smaller, too. The reverse is true when the object is larger after the saccade. These findings suggest that an object feature as size is a relevant signal that influences the saccadic system and the size distortion following saccadic adaptation indicates that the representation of the central part of visual field is critical for interaction between hand and object or object recognition.