bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lions, Bees, and Chameleons: unravelling the entrepreneurial archetypes and their impact on performance and well-being
Authors: Sawang Sukanlaya , Alshibani Safiya Mukhtar , Ng Poh Yen 
Published: February 2025

PurposeThis study explores the complex relationship between a founder’s social identity and the Dark Triad traits. It aims to provide a more nuanced understanding of entrepreneurial behaviours and their subsequent impact on enterprise performance and founders’ well-being.Design/methodology/approachDrawing inspiration from the animal kingdom, we identify three entrepreneurial archetypes: Lions, Bees, and Chameleons, using latent profile analysis (LPA) of 28,853 active entrepreneurs. Lions, embodying a balanced competitiveness, exhibit a strategic blend of dominance and communal living. As collaborative visionaries, Bees showcase a strong inclination towards teamwork and purpose-driven collaboration. Chameleons, the strategic individualists, reveal adaptability and calculated approaches to competition.FindingsThe study reveals that these archetypes impact well-being and performance outcomes differently. Lions, Bees, and Chameleons contribute uniquely to entrepreneurial success, highlighting the diverse factors influencing business performance and individual satisfaction.Originality/valueBy exploring the multifaceted nature of entrepreneurial behaviour, this research offers valuable insights into how social identity and personality traits shape entrepreneurial success. Identifying distinct archetypes enriches the current understanding of entrepreneurial dynamics, providing practical implications for individuals and businesses aiming to thrive in competitive environments. Additionally, the findings hold significant implications for policymakers seeking to foster a conducive environment for entrepreneurship and innovation. Understanding the unique characteristics of different entrepreneurial archetypes can inform the design of policies and programs tailored to support diverse entrepreneurial ventures and enhance overall economic growth.
I’ll have what I had before, but with a cherry on top: leveraging status quo bias when introducing organizational change
Authors: McLaren Tom A.S. , Fein Erich C. , Ireland Michael , Malhotra Aastha 
Published: February 2025

PurposeThe purpose of this study is to test whether presenting organizational change in a way that promotes the status quo will result in increased employee support for the change.Design/methodology/approachUsing quantitative methodology, categorical data were collected through an online cross-sectional survey in which 222 adult respondents participated. The items used vignette-based question blocks with fixed response options. Item responses were analyzed using an exact binomial test – focusing on the relationship between status quo bias and other responses to change communications.FindingsThe findings demonstrated that status quo bias has an association with employee sensemaking. These results suggest that status quo bias can be utilized by organizational leaders and change practitioners to endorse change efforts. Furthermore, it not only appears that promoting what is staying the same but also including a small reason to justify the change can bring additional advantage. Advertising a vision of radical transformation is problematic as it may actually heighten employee resistance.Originality/valueThis research explores and presents a convergence between organizational change management and behavioral economics – specifically, status quo bias. No other comparable study collecting data across a number of organizational change themes and critiquing existing change management models could be found during the preparation of this research effort.
Technology-mediated learning in the workplace: influence of personalization
Authors: Bhushan Pravasi , Sengupta Atri , Abraham Christopher 
Published: February 2025

PurposeTechnology-mediated learning (TML) is gaining popularity among business organizations for upskilling their employees. However, high dropout rates have limited its effectiveness. Thus, we explore, if and how personalization of TML can improve its adoption and effectiveness in workplaces from the lens of the unified theory of acceptance and use of technology (UTAUT2) theory.Design/methodology/approachAn exploratory sequential mixed-method design was used for this study. Study 1 included interviews (N = 27) of Learning and Development (L&D) leaders and employees (learners) of large global organizations, about their experiences with TML. Emergent themes led us to our research model, which integrates constructs of personalization, technology adoption and transfer of training (TT). In Study 2, a cross-sectional study was conducted. Data were collected from employees who have experienced TML (N = 406) and analyzed using PLS-SEM.FindingsFindings suggested that personalization of TML positively influenced intent to use TML and transfer skills, thereby improving TML effectiveness and proving its relevance in workplaces. Precisely, personalized TML recommendations from managers impacted (1) behavioral intention (BI) and TT directly; (2) BI through performance expectancy (PE); (3) TT through social influence and BI individually; and (4) TT through PE and BI sequentially. Likewise, allowing employees the flexibility to choose TML based on their interests influenced (1) BI directly and via hedonic motivation (HM) and (2) TT via HM and BI individually and sequentially.Practical implicationsUsing our model, L&D practitioners may design and personalize their TML ecosystems to foster adoption and transfer of training in workplaces.Originality/valuePersonalization of learning in workplaces has received scant attention; thereby, our study expands existing knowledge in this relatively nascent field of research.
Glycine betaine treatment: Effects on alleviating chilling injury and related gene expression in ‘Youhou’ sweet persimmon during cold storage
Authors: He Yiheng , Pan Yangxia , Wang Xiaoli , Wang Yuyang , Xu Wenlong 
Published: February 2025

AbstractPersimmon fruit is highly susceptible to chilling injury (CI) during cold storage. Notably, glycine betaine (GB), a compound that helps regulate cell osmotic balance, can alleviate postharvest CI in various fruits. In this study, the postharvest application of GB increased chilling tolerance, delayed CI, and reduced the CI index in ‘Youhou’ sweet persimmon fruit during cold storage. Moreover, GB treatment markedly decreased the O2−· production rate and malondialdehyde (MDA) and H2O2 content while significantly increasing the ascorbic amounts of acid and glutathione (GSH). Compared with the control group, GB treatment increased activities of antioxidant enzymes such as glutathione reductase (GR), glutathione peroxidase (GPX), ascorbate peroxidase (APX), catalase (CAT), and superoxide dismutase (SOD). GB treatment also reduced the activities of phenylalanine ammonia‐lyase, polyphenol oxidase, and peroxidase. RNA sequencing revealed that GB treatment significantly altered gene expression linked to sugar metabolism, GSH metabolism, and phenylpropanoid biosynthesis. This study provides novel insights into the regulatory mechanisms of GB treatment alleviating CI in postharvest persimmon fruit.Practical Application‘Youhou’ sweet persimmons are prone to rapid softening after harvest. This softening process can be limited through cold storage; this can also result in chilling injury (CI). The research findings suggest that glycine betaine (GB) treatment delays ‘Youhou’ persimmon fruit softening and alleviates CI during cold storage. GB application could be a feasible technique for extending the storage life of ‘Youhou’ sweet persimmon fruit.
Comparison of AI‐based retinal fluid monitoring in neovascular age‐related macular degeneration with manual assessment by different eye care professionals under optimized conditions
Authors: Michl Martin , Gerendas Bianca S. , Gruber Anastasiia , Goldbach Felix , Mylonas Georgios , Leingang Oliver , Bühl Wolf , Sacu Stefan , Bogunovic Hrvoje , Sadeghipour Amir , Schmidt‐Erfurth Ursula 
Published: February 2025

AbstractPurposeTo investigate whether automated intra‐ and subretinal fluid (IRF/SRF) volume measurements are equivalent to manual evaluations by eye care professionals from different backgrounds on real‐world optical coherence tomography (OCT) images in neovascular age‐related macular degeneration (nAMD).MethodsRoutine OCT images (Spectralis, Heidelberg Engineering) were obtained during standard‐of‐care anti‐VEGF treatment for nAMD at a tertiary referral centre. IRF/SRF presence and change (increase/decrease/stability) were assessed without time constraints by five retinologists, three ophthalmology residents, three general ophthalmologists, three orthoptists and three certified readers. Fluid volumes were segmented and quantified using a regulatory‐approved AI‐based tool (Vienna Fluid Monitor, RetInSight, Vienna, Austria). Sensitivity/specificity (Sen/Spe) for grading fluid presence and kappa agreement were calculated for each group. Their performances in distinguishing between IRF/SRF increase and decrease were assessed using AUCs.ResultsAbout 124 follow‐up visit pairs of 59 eyes with active nAMD were included. Across all five groups, fluid volumes >5 nL were identified with values of 0.81–0.95 (Sen)/0.70–0.91 (Spe) for IRF and 0.89–0.98 (Sen)/0.74–0.90 (Spe) for SRF. Interpretations of IRF changes between −17 nL and +3 nL and SRF changes between −9.30 nL and +6.50 nL were associated with Sen > 0.80 and Spe > 0.87 among all groups. Agreements between the algorithm and groups in grading IRF/SRF presence ranged from κ = 0.69–0.82/0.73–0.79. The AUC for correctly classifying fluid change was >0.89 across all groups.ConclusionEye care professionals with different levels of clinical expertise assessed disease activity on standard OCT images with comparable accuracy. Despite optimizing the methodology and time resources, manual performance did not reach the high level of automated fluid monitoring.
Could Flumazenil Be Used Pre‐hospital by Intramuscular Injection for Coma due to Mixed Drug Overdose Not Responding to Naloxone?: A Systematic Review of the Evidence
Authors: Farcas Ilinca , Schölin Lisa , Eddleston Michael 
Published: February 2025

ABSTRACTBackground/RationaleBenzodiazepine‐involved overdose deaths are increasing. Flumazenil is rarely used due to fear of seizures; however, the risk benefit may favour its use. Flumazenil is licensed for intravenous (IV) use, but intramuscular (IM) treatment would be required pre‐hospital.ObjectiveTo identify and synthesise pre‐clinical and clinical data on the parenteral IM flumazenil safety and efficacy.MethodsPubMed, Google Scholar, Cochrane and Scopus searches without any language restriction. Adverse effect studies were limited to systematic reviews and large cohort studies (n > 100), IM administration efficacy to studies in large animal (mammalian, excluding reptiles and birds) and humans.ResultsTwo systematic reviews reported adverse effects from IV or IM flumazenil in clinical use and combined retrospective/prospective patient cohort. Seizures were uncommon (< 2%) including mixed overdoses. Seven studies (four animal, three human) reported on IM flumazenil. Animal studies indicated IM flumazenil efficacy. In a canine cross‐over study, IM flumazenil reversed midazolam sedation moderately slower than IV. Two clinical observational studies reported sedation reversal with IM flumazenil, whereas a cross‐over study found no IM flumazenil response at 15 min.ConclusionIM flumazenil data are sparse, but it may be effective and safe. Clinical research is urgently needed to determine whether pre‐hospital IM flumazenil can prevent benzodiazepine‐involved overdose deaths.
Impacts of the Preschool Safe Program on Marginalized Girls in Northern Nigeria
Authors: Wolf Sharon , Bernard Johanna , Ezeugwu Chika R. , Ahmad Lubabatu , Bello Gurin Khadijah 
Published: February 2025

ABSTRACTQuality early childhood education (ECE) can improve children's learning and development in low‐ and middle‐income countries, but little evidence exists of programs targeting marginalized girls in vulnerable rural communities. This study used a matched‐pair mixed‐methods community‐randomized trial to evaluate a preschool program for marginalized girls (N = 466, Mage = 5‐years; W1 = 2022; W2 = 2023) from 16 rural Hausa‐ethnic communities in Nigeria. The program yielded considerably large impacts on every domain of school readiness assessed (dt = 0.89–1.52). In qualitative interviews (N = 30, data collected in 2023), parents discussed witnessing their daughters' learning and development as well as their future educational and life goals for their daughters. Results demonstrate that access to high‐quality ECE in highly disadvantaged communities can dramatically improve girls' learning and potentially change parental perceptions about girl‐child education.
Strabismus in Genetic Syndromes: A Review
Authors: Kilic Seyda , Bove Jillian , So Bethany Nahri , Whitman Mary C. 
Published: February 2025

ABSTRACTStrabismus is a feature of many genetic syndromes, with highly variable penetrance. The congenital cranial dysinnervation disorders (CCDDs) result in paralytic strabismus, with limited eye movements. CCDDs result from either deficits in differentiation of the cranial motor neuron precursors or from abnormal axon guidance of the cranial nerves. Although most individuals with comitant strabismus are otherwise healthy, strabismus is a variable feature of many genetic syndromes, most commonly those associated with intellectual disability. We review 255 genetic syndromes in which strabismus has been described and discuss the variable penetrance. The association with intellectual disability and neurological disorders underscores the likely neurological basis of strabismus, but the variable penetrance emphasises the complexity of strabismus pathophysiology. The syndromes described here mostly result from loss of function or change in function of the responsible genes; one hypothesis is that nonsyndromic strabismus may result from altered expression or regulation of the same genes.
Historical Demographic Determinants Complement Climate Model Predictions of Co‐Occurring Cryptic Species
Authors: Jurado‐Angulo Pilar , García‐París Mario 
Published: February 2025

ABSTRACTAimWe explore the impact of demography and biogeographic history on the interpretation of ecological niche model, highlighting the potential for integrating genetic and ecological approaches to elucidate the evolutionary dynamics underlying the geographic distributions of cryptic species.LocationWestern Palaearctic (Africa and Europe).MethodsWe conducted intensive sampling across the Iberian Peninsula to obtain mtDNA phylogeographic data and to develop fine‐scale ecological niche models, projecting these models into both past and future scenarios for the cryptic earwigs Forficula dentata and F. mediterranea. Additionally, we utilised Bayesian skyline plot (BSP) analyses to reconstruct demographic histories and infer past population trends for both species.ResultsThe phylogeographic patterns revealed divergent evolutionary histories: F. dentata exhibited a well‐established, geographically structured lineage, whereas F. mediterranea displayed a star‐shaped pattern characteristic of recent expansion. Comparison between current climate models and those projected into the past and future indicate that F. dentata is likely facing a substantial reduction in its suitable habitat due to ongoing climate change, possibly exacerbated by increasing competition with F. mediterranea.Main ConclusionsOur results suggest that climatic factors alone cannot determine the distribution of cryptic species. Historical and demographic factors play a crucial role in shaping their current geographical structure. In addition, human‐mediated dispersal and ongoing climate change may contribute to the genetic and spatial structure within the F. auricularia species complex. Overall, exploring the intricate interplay between historic, genetic and geographic distribution is recommended to overcome contradictory predictions of climate models.
Fixed dose combination of dapagliflozin, glimepiride and extended‐release metformin tablets in patients with type 2 diabetes poorly controlled by metformin and glimepiride: A phase III, open label, randomized clinical study in India
Authors: Sahay Rakesh , Gangwani Dinesh , Singh Manish , Gupta Sandeep , Kale Narendra , Srivastava Manoj , Kurmi Prakash , Ambaliya Jayesh , Lomte Nilesh , Gofne Sandip , Agarwal Saurabh , Kashid Priyanka , Agarwal Vikas , Rai Pradeep , Sharma Surendra , Murthy L. Sreenivasa , Rajurkar Mandodari , Saha Shruti , Patel Piyush , Patil Dipak , Ghadge Pravin , Lakhwani Lalit , Mehta Suyog , Joglekar Sadhna J. 
Published: February 2025

AbstractAimTo evaluate the efficacy and safety of a triple fixed‐dose combination (FDC) therapy of dapagliflozin + glimepiride + metformin hydrochloride extended‐release (DAPA + GLIM + MET ER) tablets in Indian patients with type 2 diabetes mellitus (T2DM) inadequately controlled by combination of GLIM + MET.Materials and MethodsA phase III, randomized, open‐label, active‐controlled study was conducted for a maximum 30 weeks (primary treatment [16 weeks]; uptitration [12 weeks] and follow‐up [2 weeks]). Eligible patients were randomized in a 1:1 ratio to receive either the FDC of DAPA + GLIM + MET ER or the FDC of GLIM + MET prolonged‐release (PR) once‐daily. The primary efficacy endpoint was a change in glycated haemoglobin (HbA1c) from baseline to week 16.ResultsThe mean reduction in HbA1c from baseline to week 16 was significantly greater with the FDC of DAPA + GLIM + MET ER compared to the FDC of GLIM + MET PR (−1.98% ± 1.01% vs. −1.64% ± 0.86%, p = 0.0047). The mean reduction in HbA1c from baseline to week 12 was significantly greater with the FDC of DAPA + GLIM + MET ER versus dual FDC (p < 0.0001). The proportion of patients achieving HbA1c <7.0% was significantly greater with the FDC of DAPA + GLIM + MET ER versus dual FDC at week 12 (19.1% vs. 6.5%; p = 0.0002) and week 16 (52.6% vs. 36.7%; p = 0.0015). A significant decrease in HbA1c, fasting and post‐prandial blood glucose from baseline to weeks 12, 16, and 28 was observed in both arms. The incidence of TEAEs was similar across both arms.ConclusionThis study demonstrated that the FDC of DAPA + GLIM + MET ER tablets once daily was significantly better than dual FDC in achieving glycaemic control in patients with poorly controlled T2DM. Both treatments were well‐tolerated.Trial RegistrationCTRI/2022/03/041424, registered on 28 March 2022.
Uncommon Causes of Pulmonary Hypertension With Associated Cardiomyopathy: Computed Tomography and Magnetic Resonance Imaging of Cardiothoracic Manifestations
Authors: Muscogiuri Emanuele , Van Ballaer Valerie , De Wever Walter , Di Dedda Emanuele , Dubbeldam Adriana , Godinas Laurent , Delcroix Marion , Bogaert Jan 
Published: February 2025

ABSTRACTPulmonary hypertension (PH) is a disease characterized by pathologically increased pressure in the pulmonary arteries, defined by a mean pulmonary arterial pressure (mPAP) >20 mmHg at rest measured with right heart catheterization (RHC). This definition encompasses pathologies with very different pathological backgrounds, ultimately resulting in PH. For this reason, the latter can be possibly (though seldom) accompanied by cardiomyopathies, pathologies characterized by a structural and functionally abnormal myocardium not secondary to coronary disease, hypertension, valvular disease, or congenital heart disease. Notable examples of these diseases are sarcoidosis (a multi‐systemic inflammatory granulomatous disease, possibly involving the lung and the heart), systemic sclerosis (SSc) (a connective tissue disease [CTD], possibly causing interstitial lung disease [ILD], direct as well indirect involvement of the cardiovascular system), and chronic kidney disease (CKD) (a progressive pathological process involving the kidneys, with multi‐systemic involvement and possible development of a peculiar form of cardiomyopathy, i.e., uremic cardiomyopathy [UC]). The diagnostic work‐up of patients with coexistent PH and cardiomyopathies implies the use of multiple imaging techniques, with computed tomography (CT) and cardiovascular magnetic resonance (CMR) being among the most important. The knowledge of CT and MRI findings, together with a suggestive clinical picture, forms the basis for a correct diagnosis, therefore it is important for the radiologist to recognize them in complex clinical scenarios. The advent of new technologies (e.g., photon counting detectors) and the development of new artificial intelligence (AI) algorithms will further pave the way for improved diagnostic processes (also regarding this kind of pathologies) as well as allowing to perform a better prognostic evaluation.
Differences Between Users and Professionals in Preferences for Youth Mental Health Service Attributes: A Discrete Choice Experiment
Authors: Wittevrongel Eline , Kessels Roselinde , Everaert Geert , Vrijens May , Danckaerts Marina , van Winkel Ruud 
Published: February 2025

ABSTRACTIntroductionPrevious work showed that young people prefer youth‐oriented mental health services that offer individual help in houses in urban areas, with short wait times and low costs. The present paper aims to examine which service options professionals working in social welfare or mental health services prefer for addressing young people's mental health needs, comparing their views with those of young people.MethodsProfessionals (N = 176) and youth aged 16–24 years (N = 258) participated in a discrete choice experiment (DCE). Panel mixed logit (PML) models were used in both stakeholder groups to ascertain relative differences in attribute weights. We also estimated an overall PML model incorporating the effect of stakeholder group on the attributes.ResultsProfessionals found the attributes ‘cost’ and ‘wait times’ most relevant to young people's mental health service needs, indicating a preference for services characterised by affordability and minimal wait periods. In contrast, young people adhered more importance to the attribute ‘format’ (individual rather than group therapy). Furthermore, professionals considered a café or youth centre the most suitable location for a service, rather than a house in the city, and they disfavoured care provision by professionals in adult mental health services more than young people did. Finally, the attributes ‘peer support’, ‘opening hours’ and ‘anonymity’ were deemed relevant by professionals but not by young people.ConclusionThe perspectives of both professionals and young people offer a unique point of view on care provision, stressing the importance of integrating them in preference‐based research and service design.