bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late Phase Allergic Reaction to a CT Contrast Medium (Iotrolan)
Authors: Kanzaki Tamotsu , Sakagami Hiroshi 
Published: April 2015

AbstractA 46‐year‐old male developed wide‐spread erythema and edema after intravenous injection of a CT contrast medium (iotrolan). The skin eruption appeared at 6 h, reached a maximum at 9 to 12 h, and faded within 36 h after injection. A challenge with an intradermal injection of the agent provoked the same reaction where the eruption had originally appeared, but had no effect on previously unaffected regions. Histopathologic examination revealed a perivascular infiltration of small round cells, and a few neutrophils, and eosinophils in the dermis and focal spongiosis in the epidermis. This is the first report of a late phase allergic skin reaction induced by iotrolan.
Experimental Production of DLE Lesion with a Single Exposure to UVB (2.7 MEDs) Radiation
Authors: Higuchi Dousei , Ogura Yukari , Watanabe Hideyoshi , Takiuchi Iwao 
Published: April 2015

AbstractKeratotic erythematous lesions developed on the face, ears, neck, and upper back of a 38‐year‐old man. The patient had a history of photosensitivity to sunlight manifested by the development of new lesions. One week after an MED (2.7 mJ/cm2) was determined using UV‐B light, persistent erythema with fine scales were observed at test sites irradiated over 72 mJ/cm2. These lasted for at least 2 months. A biopsy specimen obtained from the test site irradiated at 72 mJ/cm2 showed liquefaction degeneration of the basal cell layer. Within the upper part of the dermis, perivascular and disseminated lymphocytic infiltrates were seen. However, when irradiated again under the same conditions 7 and 12 months after the initial phototest, no persistent erythema was observed.
Trigeminal Trophic Syndrome
Authors: Tada Joji , Ueda Masumi , Abe Yoshiko , Fujiwara Hideki , Arakawa Kenzo , Arata Jirô 
Published: April 2015

AbstractThree Japanese patients with trigeminal trophic syndrome, a rare dermatosis in Japan, were reported. Cutaneous lesions were a long‐standing ulcer and destruction of the right ala nasi in case 1, a persistent deep ulceration on the forehead after a small trauma in case 2, and development of small, discrete ulcers on the right forehead during the treatment of a postherpetic neuralgia in case 3. A protective device was very effective in one patient.
Milialike Idiopathic Calcinosis Cutis and Syringoma in Down's Syndrome
Authors: Kanzaki Tamotsu , Nakajima Masaru 
Published: April 2015

AbstractA 6‐year‐old girl with Down's syndrome presented milialike whitish small papules on her hands and feet and periorbital syringoma. Histopathological examination of the hand lesion revealed small localized calcium deposits and syringoma in the adjacent upper dermis. This is a very rare but typical case of calcinosis cutis with syringoma in a patient with Down's syndrome.
A Case of Cutaneous Metastases of Gastric Carcinoma Showing Peculiar Clinical Features
Authors: Miyashita Mitsuo , Honjo Michio , Suzuki Hiroyuki , Yamagami Hiroaki , Shioda Atsuo , Arakawa Yasuyuki , Matsuo Yutaka 
Published: April 2015

AbstractA 52‐year‐old male patient presented with multiple cutaneous nodules on the face, trunk, and upper extremities. Examination of a skin biopsy specimen disclosed numerous signet ring cells throughout the dermis. Histopathologic examination of the stomach, along with gastroscopy, revealed that the cutaneous metastases were of gastric origin.The metastatic skin lesion on the shoulder and the back of the patient grew relatively rapidly, showing an erysipelas‐like lesion followed by prominently large tumor masses. The clinical appearance seen in our case is thought to be rare.Radiotherapy and chemotherapy appeared to be effective in reducing some tumors and the swelling on the anterior of the neck, and in prolonging life.
Differentiation Disorders of Keratinocytes in Seborrheic Keratosis (Acanthotic Type)
Authors: Fujisawa Hiroshi , Naito Yukiko , Muraki Ryouichi , Baba Torn 
Published: April 2015

AbstractSince the differential disorder of keratinocytes in seborrheic keratosis remains to be elucidated, the differentiation of seborrheic keratosis (acanthotic type) was examined immunohistochemically using a lectin and two anti‐keratin monoclonal antibodies. A lectin, peanut agglutinin (PNA), and anti‐keratin monoclonal antibody, 34betaB4, recognize the whole epidermis except for the basal layer in the normal epidermis. In seborrheic keratosis (acanthotic type), cells unstained with either PNA or 34betaB4 were found throughout the entire tumor. In the upper part of the tumor, some cells appeared to undergo keratinization without expressing the differential markers recognized by PNA or 34betaB4. Another anti‐keratin monoclonal antibody, 34betaE12, stained the tissues in the same way as in the normal epidermis. Thus it was indicated that, in seborrheic keratosis (acanthotic type), although differentiation was partially maintained, some cells might undergo maturation without expressing the differentiation markers recognized by PNA or 34betaB4.
Factor XIIIa Expression in Pseudo‐Kaposi Sarcoma
Authors: Murakami Yoshiyuki , Nagae Shonosuke , Hori Yoshiaki 
Published: April 2015

AbstractA 39‐year‐old man had pseudo‐Kaposi sarcoma on his left foot. A biopsy specimen obtained from a cutaneous lesion showed increased numbers of vascular spaces, proliferation of fibroblast‐like spindle cells, and deposition of hemosiderin in the dermis. Immunohistochemically, proliferative fibroblast‐like spindle cells around the vessels were positive for anti‐factor XIIIa antibody. Excessive heat radiation was detected from the skin lesions by thermography.
Chalazion Coexisting with Dacryolithiasis
Authors: Nishimura Masayuki , Hori Yoshiaki 
Published: April 2015

AbstractA 41‐year‐old woman presented with a painless hard subcutaneous nodule in the right upper eyelid. The lesion was diagnosed clinically as pilomatricoma and removed surgically. Histological examination disclosed a granulomatous lesion composed mainly of mononuclear cells with a foamy appearance and multinucleated giant cells with some admixture of granulocytes, plasma cells, and lymphoid cells. Lipid droplets and dilated ductal structures containing an eosinophilic fibrillar substance were observed in and around the granulomatous lesion. In addition, an intraductal dacryolith was seen near the granulomatous lesion. We finally diagnosed this case as chalazion; the coexisting dacryolithiasis was considered to be involved in the pathogenesis of chalazion.
H1 Histones Contribute to Candidacidal Activities of Human Epidermal Extract
Authors: Kashima Masato 
Published: April 2015

AbstractIn the study of the purification of candidacidal cationic proteins from human epidermis by using high performance liquid chromatography, it was found that these proteins were composed of several groups. Among them, the most active group was purified. The amino acid compositions of this protein group were almost the same as those of human splenic H1 histones. The results of immunoblotting suggested that the proteins were human epidermal H1 histones. The killing speed of the epidermal H1 histone was very rapid, 8 μg of the protein killed 90% of Candida tropicalis (1 times 105 CFU) within 10 minutes. The cidal activity increased in lower pH conditions and decreased at higher ionic strengths. Because nuclei of the epidermis disintegrate in the granular layer, it is suggested that, in this layer, nuclear histones may be released from the nuclei. My immunohistochemical results suggest that H1 histones may contribute to form a barrier which inhibits candida from invading deeper than the granular cell layer in cases of skin candidial infection.
Intralesional Human Leukocyte Interferon Treatment Alone or Associated with IL‐2 in Non‐AIDS Related Kaposi's Sarcoma
Authors: Ghyka Gregory , Alecu Mihai , Halalau Florin , Coman Gabriela 
Published: April 2015

AbstractPatients with classical European Kaposi's sarcoma were treated by intra‐ and peritumoral injections of human alpha leukocyte interferon (IFN) (12 cases) or, alternatively, with IFN and naturally synthesized IL‐2 (8 cases).All the patients were HIV negative with tumors which had been present for at least six months. In each patient, one tumor received 1 ml (50,000 IU) IFN alone or alternatively associated with 1 ml IL‐2 twice a week for 4–6 weeks; another nodule situated 10–12 cm away was considered as a control and remained uninjected. The clinical follow‐up revealed that, in the same patient in the same anatomical area, the treated nodule was cured in all the investigated cases; the untreated one was not. These data strongly suggest that IFN is the factor responsible for the involution and final cure of these Kaposi tumors treated by perilesional inoculations. Association with IL‐2 (and certainly also other interleukins) increases the beneficial clinical activation of the tumor involution.Histological examination showed that important histopathological changes occur in the treated nodules: complete disappearance of the Kaposi's aspect, fibrosclerous modifications progressively replacing the fibroblasts characteristic of Kaposi's sarcoma, abundant infiltrations of leukocytes, especially lymphocytes and necrotic patches, often with hemorrhagic centers. IL‐2 association seems to especially induce this last type of histological phenomenon.
Inoculation Lupus Vulgaris
Authors: Sehgal Virendra N. , Jain Sanjiv , Gupta Rakesh 
Published: April 2015

AbstractAn 11‐years‐old girl with lupus vulgaris on the right buttock following inoculation is described. The diagnosis was formed by the history, morphological characteristics, Mantoux test, histopathology, and was supported by an affirmative response to short course intensive chemotherapy (6 months). This route of infection acquires special significance with the worldwide‐spread of HIV infection.
Langerhans Cells, Inflammation Markers and Human Papillomavirus Infections in Benign and Malignant Epithelial Tumors from Transplant Recipients
Authors: Viac Jacqueline , Chardonnet Yvette , Euvrard Sylvie , Chignol Marie Christine , Thivolet Jean 
Published: April 2015

AbstractOrgan transplant recipients frequently develop warts which progress toward premalignant or malignant lesions after a rather long grafting period. The local immune responses of such lesions (warts, condyloma acuminata, actinic keratoses, Bowen, basal and squamous cell carcinomas) was studied in 32 frozen skin specimens taken from 15 male transplant recipients and compared to similar lesions from the normal population. We studied the expression of T cell subsets, Langerhans cell phenotype, HLA class 1 (β2‐microglobulin), HLA class 2 (DR antigen), and intercellular adhesion molecule 1 (ICAM 1). The presence of HPV infection was also considered, using in situ hybridization with biotinylated probes in order to examine the correlation with immunological markers. In the dermis, the lesions from grafted patients showed a moderate to intense inflammatory reaction of HLA‐DR‐positive cells. Most of these cells were CD4+ and CD8+ without any predominance of a single T cell subset. In the epidermis, most lesions were characterized by a reduced number of CD1‐positive cells; this was concomitant with a decrease or a loss of β2‐microglobulin expression by epithelial cells. HLA‐DR antigen was not expressed by keratinocytes or tumoral cells in any specimen; ICAM 1 antigen was observed in a few cases. The expression of these markers was similarly modified with or without the presence of HPV DNA. Conversely, most lesions from non‐immunocompromised patients, except warts, showed intense inflammatory reactions, with a predominance of CD4‐positive cells and large foci of ICAM 1‐positive cells. Expression of activation markers by keratinocytes occurred mainly in condylomas and squamous cell carcinomas. In the normal population, HPV infection was only detected in papilloma lesions. These data indicate, in lesions from grafted patients, a lack of effective immune response with partial inhibition of activation markers expressed by keratinocytes. It is conceivable that immunosuppressive treatment with solar exposure may also be responsible for the local immune deficiency and thus for the conversion of benign warts toward malignant lesions in grafted patients.
Detection of Selenium in Generalized and Localized Argyria: Report of Four Cases with X‐ray Microanalysis
Authors: Matsumura Tetsuri , Kumakiri Masanobu , Ohkawara Akira , Himeno Hiroshi , Numata Tsunemi , Adachi Riri 
Published: April 2015

AbstractElectron microscopic and X‐ray microanalytic studies were performed on four cases of argyria; one generalized and three localized. Deposition of electron dense granules was predominantly found on elastic fibers and around basal laminas of secretory portions of eccrine glands, although the amount of deposition was much less in the case of generalized argyria. In all four cases, X‐ray microanalysis revealed that the depositions consisted mainly of silver, selenium, and sulfur. The importance of selenium in the detoxification of heavy metals was discussed.
Malignancy and Interstitial Pneumonitis as Fatal Complications in Dermatomyositis
Authors: Hidano Akira , Torikai Sayori , Uemura Tomoko , Shimizu Satoru 
Published: April 2015

AbstractBy sending questionnaires to the major dermatological clinics in Japan, we examined the outcome and causes of death in 182 cases of dermatomyositis (DM) observed between 1983 and 1987. The mortality rate in adults was 26.7%. Associated malignancy occurred in 47 cases (25.8% of adults), and 16 of them died of neoplasms. In contrast to 43 carcinomas, only 1 patient died of lymphoma. Associated interstitial pneumonitis (IP) appeared in 31 cases. IP started simultaneously or within 6 months after the diagnosis of DM in the majority of these cases. Of the 13 fatal cases due to IP, 8 died of respiratory failure within two months of the onset of lung disease. In the malignancy group, periungual erythema was noted in a higher proportion. Raynaud's phenomenon was more frequently noted in the IP group. DM overlapped with other collagen diseases in 14 cases.
Reduction of Environmental Mites Improved Atopic Dermatitis Patients with Positive Mite‐patch Tests
Authors: Kubota Yumiko , Imayama Shuhei , Hori Yoshiaki 
Published: April 2015

AbstractDuring a series of studies on the involvement of house dust mite antigens in 183 cases of atopic dermatitis, we observed an improvement in two patients following the removal of mites from their environment by means of a thorough housecleaning and replacement of the mattress. Both patients manifested the typical clinical skin lesions of atopic dermatitis and had similar laboratory findings. Although the serum IgE concentrations and specific IgE to Dermatophagoides pteronyssinus and Dermatophagoides farinae were each relatively low, the results of patch tests with these antigens were positive. Thus, a regimen aimed at reducing the presence of house dust mites can produce clinical improvement in a subset of patients with atopic dermatitis who show contact hypersensitivity to mite antigens on skin testing, but negative results on IgE (RAST; radioallergosorbent technique) testing.
A Case of Lymphadenosis Benigna Cutis of the Earlobe: An Immunohistochemical Study
Authors: Murata Yasuko , Toyoda Hiroyuki , Nogita Toshitatsu , Kawashima Makoto , Hidano Akira , Kasajima Takeshi 
Published: April 2015

AbstractWe report a 38‐year‐old woman who developed an erythematous nodule on her earlobe after wearing pierced‐type 18‐carat gold earrings. Biopsy specimens revealed dense cellular infiltration predominantly composed of lymphocytes and plasma cells in the dermis and subcutaneous tissue with formation of lymph follicles. Morphological and immunohistochemical analyses were compatible with lymphadenosis benigna cutis.
Superficial Epithelioma with Sebaceous Differentiation
Authors: Kato Naoko , Ueno Hiroo 
Published: April 2015

AbstractIn 1980, Rothko, Farmer, and Zeligman first described the disease entity “Superficial epithelioma with sebaceous differentiation” as a histologically distinct, rare, benign lesion. We report here the first Japanese case fitting this description. The patient is a 38‐year‐old Japanese woman, who had a small, yellow, flat‐topped, well‐defined plaque on her right upper eyelid. Histologically, the lesion was a multilobular, superficial, dermal tumor with numerous broad attachments to the overlying epidermis. The overall configuration was a plate‐like proliferation of tumor cells with well‐defined borders. The tumor cells were basically uniform basaloid cells with single or clustered sebocytes in the upper part of the tumor and multiple well differentiated sebaceous lobules in the middle and lower parts of the tumor. Multiple cystic spaces were formed in the lobules. Differential diagnosis of several tumors with sebaceous differentiation is discussed.
The Ultrastructural Histopathology of Eosinophilic Pustular Folliculitis
Authors: Horiguchi Yuji , Mitani Tsuneo , Ofuji Shigeo 
Published: April 2015

AbstractThe follicular skin lesions of a patient with eosinophilic pustular folliculitis were investigated by electron microscopy. Pustules in the outer root sheath contained acantholytic keratinocytes with numerous microvilli and features of desmosomal cleavage. The infiltrating eosinophils and neutrophils exhibited autolytic or degenerative changes rather than degranulation. The aggregated tubulo‐vesicular structures were associated with the debris of autolytic eosinophils. Multiple, tiny, bubble‐like structures enclosed within a membrane were frequently seen in the intercellular space. The intercellular space of the outer root sheath was widened with decreased desmosomal adhesion between the keratinocytes, but no intracellular edema was detectable. The infiltrating lymphocytes, predominantly T‐cells with convoluted nuclei, extended cytoplasmic processes to adjacent keratinocytes. Apposition of T‐lymphocytes and Langerhans cells was noted. Some keratinocytes in the outer root sheath contained large, sebaceous lipid droplets. No obvious virus particles or other pathogenic agents were detected. It is possible mat T‐lymphocytes and other immunosurveillance cells are involved in the pathomechanism of eosinophilic pustular folliculitis.
Tsutsugamushi Disease in the Central Part of Japan
Authors: Kanno Yuko , Taniguchi Yoshiki , Sakamoto Takayoshi , Shimizu Masayuki , Ando Katsuhiko 
Published: April 2015

AbstractTwo cases of tsutsugamushi disease misdiagnosed initially as drug eruption were reported. Clinical symptoms of both cases disappeared dramatically after starting minocycline. Statistical examinations were performed on 29 cases of tsutsugamushi disease, including those observed in Mie Prefecture since 1982. Half of them were seen in the last 2 years. The onset was predominantly recorded in November (59%). Presumptive sites of infection were forests (63%) and fields (21%). No patients were infected along river‐banks.
“Giant” Senile Sebaceous Hyperplasia
Authors: Kato Naoko , Yasuoka Atsushi 
Published: April 2015

AbstractAlthough the usual size of senile sebaceous hyperplasia is 2 to 3 mm in diameter, we report one “giant” nodular case on the face. The patient is a 75‐year‐old Japanese man with a dome‐shaped, skin‐colored nodule on his right cheek. The lesion was 10 mm in diameter and had multiple small umbilications on its surface. He also had several small, yellow‐colored, asymptomatic papules with central umbilication on his cheeks. Histologically, the giant nodule and the papule on the right cheek showed the same architectural pattern, a sharply demarcated hyperplasia of grouped mature sebaceous glands with a sebaceous converging duct, whose opening to the surface epithelium corresponded to the clinical umbilication. The reason for the giant growth of this senile sebaceous hyperplasia in our case is obscure; the patient had not been stressed by inductive agents or factors such as systemic corticosteroid and hemodialysis except for electrocoagulation on the lesion. In spite of the extraordinarily large size of the nodule, the conservative proliferating pattern seemed to show the benign hyperplastic character of senile sebaceous hyperplasia.
A Case of Intravascular Malignant Lymphomatosis (Angiotropic Large‐cell Lymphoma) Presenting Memory T Cell Phenotype and Its Expression of Adhesion Molecules
Authors: Setoyama Mitsuru , Mizoguchi Shimako , Orikawa Tamiko , Tashiro Masaaki 
Published: April 2015

AbstractA case of intravascular malignant lymphomatosis (angiotropic large cell lymphoma), T cell type was reported. The patient, a 59‐year‐old woman, had reddish or violaceous indurated macules scattered over the entire body surface. Neither lymphadenopathy nor hepatosplenomegaly was recognized.A chest Roentogenogram, whole body CT scan, and 67Ga‐citrate scintigraphy yielded normal findings. Serum anti‐HTLV‐1 antibody was negative.Histopathologically, lesions showed intravascular large mononuclear cell proliferation associated with occasional fibrin thrombi formation in the dermis to subcutis.Immunohistochemically, the large mononuclear cell immuno‐phenotype had a memory T cell character. Also, both lymphocyte function‐associated antigen‐1s, CD11a and CD18, and intercellular adhesion molecule‐1 were demonstrated on the tumor cells and vascular walls in the lesions.To our knowledge, the present case is the fourth case of intravascular malignant lymphomatosis in the T cell lineage.
Eosinophil Phenotypes in Bullous Pemphigoid
Authors: Tsuda Shingo , Miyasato Minoru , Iryo Kayoko , Nakama Takekuni , Kato Keiko , Sasai Yoichiro 
Published: April 2015

AbstractEosinophil phenotypes were investigated in peripheral blood and skin lesions from eight patients with bullous pemphigoid (BP). By Nycodenz density gradients fractionation, blood eosinophils were divided into two phenotypes; normodense (>1.080 g/ml) and hypodense (>1.080 g/ml). Increased numbers of hypodense eosinophils were observed in the blood from all patients with BP. Immunocytochemical observations, using an EG2 monoclonal antibody to react with the secretion form of eosinophil cationic protein (ECP), revealed that EG2 was expressed in 86 ± 3% of hypodense phenotypes and 3 ± 2% of normodense phenotypes. Ultrastructurally, hypodense eosinophils were characterized by numerous spheroidal granules, each with a lytic crystalloid core. These indicate that the hypodense phenotype represents a cell in an activated state. Only eosinophils with immunocytochemical and morphological characteristics similar to hypodense phenotypes infiltrated around the basement membrane zone in involved skin of BP. Furthermore, direct adherence of eosinophils associated with degranulation into basal keratinocytes was seen at the sites of blistering lesions. Bullous fluids contained higher concentrations of ECP than sera as determined by a radioimmunosorbent assay; thus hypodense (activated) eosinophils may directly damage the basal keratinocytes by releasing their granule proteins, subsequently leading to dermo‐epidermal separation.
Palindromic Morphea: Multiple Recurrence of Morphea Lesions in a Case of Systemic Sclerosis
Authors: Mizutani Hitoshi , Tanaka Hideyuki , Okada Hiroaki , Mizutani Tomoko , Shimizu Masayuki 
Published: April 2015

AbstractWe report an unusual scleroderma case. A 45‐year‐old woman had recurrent morphea lesions over 10 times in 6 years. She had had preceding inactive systemic scleroderma. New morphea lesions developed cyclically on various portions of her body and improved within 2 years. Interestingly, new lesions have developed on once involved skin as well as uninvolved skin. No exacerbation of systemic scleroderma was induced by outbeaks of new morphea lesions. We could not find a similar case in the literature and named it “Palindromic morphea” because of its unique clinical course.D‐penicillamine treatment had a limited effect. Minimal oral predonisolone (5 mg/day) completely suppressed the multiple recurrence of the morphea lesions and enhanced improvement of the sclerosis.