bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perioperative platelet reactivity over time in patients undergoing vascular surgery: An observational pilot study
Authors: Brand Kanters A. R. T. , Roozendaal N. C. , Parr N. M. J. , Pasterkamp G. , Urbanus R. T. , Korporaal S. J. A. , de Borst Gert J. 
Published: June 2024

Background
Despite Antiplatelet therapy (APT), cardiovascular patients undergoing revascularisation remain at high risk for thrombotic events. Individual response to APT varies substantially, resulting in insufficient protection from thrombotic events due to high on-treatment platelet reactivity (HTPR) in ≤40% of patients. Individual variation in platelet response impairs APT guidance on a single patient level. Unfortunately, little is known about individual platelet response to APT over time, timing for accurate residual platelet reactivity measurement, or the optimal test to monitor residual platelet reactivity.

Aims
To investigate residual platelet reactivity variability over time in individual patients undergoing carotid endarterectomy (CEA) treated with clopidogrel.

Methods
Platelet reactivity was determined in patients undergoing CEA in a prospective, single-centre, observational study using the VerifyNow (change in turbidity from ADP-induced binding to fibrinogen-coated beads), the VASP assay (quantification of phosphorylation of vasodilator-stimulated phosphoprotein), and a flow-cytometry-based assay (PACT) at four perioperative time points. Genotyping identified slow (CYP2C19*2 and CYP2C19*3) and fast (CYP2C19*17) metabolisers.

Results
Between December 2017 and November 2019, 50 patients undergoing CEA were included. Platelet reactivity measured with the VerifyNow (p = < .001) and VASP (p = .029) changed over time, while the PACT did not. The VerifyNow identified patients changing HTRP status after surgery. The VASP identified patients changing HTPR status after eight weeks (p = .018). CYP2C19 genotyping identified 13 slow metabolisers.

Conclusion
In patients undergoing CEA, perioperative platelet reactivity measurements fluctuate over time with little agreement between platelet reactivity assays. Consequently, HTPR status of individual patients measured with the VerifyNow and VASP assay changed over time. Therefore, generally used perioperative platelet reactivity measurements seem unreliable for adjusting perioperative APT strategy.
Combination effect of optical defocus and low dose atropine in myopia control: Study protocol for a randomized clinical trial
Authors: Chun Rachel Ka Man , Hon Ying , Law Tsz Kin , Wong Kryshell Yu Qi , To Chi Ho , Shih Kendrick C. , Leung Christopher Kai Shun , Tse Dennis Yan Yin 
Published: June 2024

Background
Myopia, characterized by excessive axial elongation of the eyeball, increases risks of having sight-threatening diseases and impose a financial burden to healthcare system. Although myopic control interventions showed their effectiveness in slowing progression, the efficacy varies between individuals and does not completely halt progression. The study aims to investigate the efficacy of combining 0.01% atropine administered twice daily with optical defocus for myopia control in schoolchildren.

Methods and design
This is a prospective, parallel-group, single-blinded, randomized, active-control trial (ClinicalTrials.gov identifier: NCT06358755). Myopic schoolchildren with no previous myopic control interventions aged between 7 to 12 years will be recruited. They will be randomly allocated into two groups (n = 56 per group) after baseline measurement. Both groups will receive 0.01% atropine twice per day for 18 months (one drop in the morning and the other drop at night before bedtime). Defocus incorporated multiple segments (DIMS) spectacle lenses will be prescribed in atropine plus optical defocus (ATD) treatment group while single vision spectacle lenses will be given in atropine only (AT) group. Cycloplegic refraction and axial lengths will be monitored every 6 months over 18-month study period. The primary outcomes are changes in cycloplegic refraction and axial lengths relative to the baseline over the study period.

Discussion
The result will examine the combination effect of low dose atropine and myopic defocus on myopia control in a randomized controlled study. The findings will also explore the potential benefits of applying 0.01% atropine twice per day on myopic control and its potential side effects.
Stability of granular media impacts morphological characteristics under different impact conditions
Authors: Wang Yifeng , Li Ran , Chi Zhipeng , Yang Hui 
Published: June 2024

Abstract
In planetary surfaces, oblique impact events are commonplace, and their study holds significant importance for understanding planetary impact processes and aiding in the design of landers and impactors. Current research predominantly focuses on simplified models to study the force and motion under vertical impact craters in terms of scale and impact loading. For oblique impacts, investigations have primarily concentrated on the final crater shape. However, the specific influence of impact load motion on particle bed movement and the precise impact angle’s effect on the ultimate crater shape during the impact process remain unclear. In this study, we used a custom-built oblique impact experimental setup to analyze changes in the velocity field of the particle bed and the horizontal movement of the impact load. Using quasi-static region to assess ellipticity, we aimed to reveal the state of particle movement during oblique impacts and explore the impact of impact angles and energies on crater formation. The results indicate that under large impact angles, the obliquely acquired kinetic energy is minimal, leading to a predominant static point source movement of the particle bed. At higher energy levels, the impact load primarily excavates downward, resulting in the formation of circular impact craters. These findings underscore the sensitivity of particle bed motion to impact angles, making it a crucial metric for assessing the impact of oblique angles on final crater morphology.
Energy-saving analysis of desalination equipment based on a machine-learning sequence modeling
Authors: Zhang Xiaodong , Jiang Yuepeng , Li Ke , Sun Yu 
Published: June 2024

Abstract
To control water quality and seawater desalination dosage, modeling the coagulation process of saltwater is crucial. With a focus on the features of seawater coagulation with a long lag, a machine-learning sequence-based modeling approach is suggested. The link between influent and effluent turbidities, flow rates, flocculant and coagulant dosages, and other parameters is modeled using structured units such as a gate recurrent unit encoder and a linear network decoder. The model’s validity is confirmed by numerical experiments based on real operating data, which also offer a solid foundation for managing flocculant and coagulant assistance reduction.
Automatic human identification using fingerprint images based on Gabor filter and SIFT features fusion
Authors: Jabar Sabat Ahily Hydr , Al Dujaili Mohammed Jawad , Abdulzahra Al Dulaimi Mohammed 
Published: June 2024

Abstract
Today, advancements in science and technology have spurred the rapid evolution of systems like electronic banking, demanding precise, swift, and secure identification of individuals based on their distinct traits. Among these traits, fingerprints stand out as a dependable means of identification, finding application in realms such as crime investigation and national border control due to their simplicity and heightened security. The qualities inherent in fingerprint-based identification have led to its widespread adoption over other identification methods. This article proposes a hybrid biometric system that integrates the Gabor filter and scale-invariant feature transform features and then uses support vector machine and K-nearest neighbors as classifiers, aiming to notably enhance authentication systems by mitigating issues seen in single-method biometric systems. Also, principal component analysis is used to reduce dimensions and eliminate redundancy. In this article, the famous database FVC2004 is used. Test results highlight the considerable reliability and accuracy of the proposed combined approach compared to systems reliant on a singular biometric method.
Study and mechanism of formation of phosphorus production waste in Kazakhstan
Authors: Smailov Bakyt , Ismailov Bakhytzhan , Zakirov Bakhtiyar , Turakulov Bakhriddin , Tursynbay Leskul , Aimenova Zhanar 
Published: June 2024

Abstract
This article contains information about the accumulated industrial waste from phosphorus production and methods for its recycling and disposal to produce marketable products. Monitoring of cottrel dust’s impact on the environment, namely, ground and surface water, soil, and atmosphere was carried out. The mechanism of formation of cottrel dust was studied. The dispersed, chemical, and phase compositions of the dust in furnace gases during the electrothermal smelting of phosphorites were determined. The sequence of chemical reactions during the formation of cottrel dust was elucidated. The ratios of initial components entering the chemical reaction and the thermodynamic parameters (Gibbs energy) were determined using the Chemistry HSC-6 software package. IR spectral and elemental analyses were carried out for determining cottrel dust’s functional groups and elemental composition. Based on modern instrumental studies, it was found that the total content of phosphorus(v) oxide in cottrel dust was 30.7%. This content of phosphorus(v) oxide is sufficient to use cottrel dust as an initial raw material for producing phosphorus-containing fertilizers. This method was proposed for processing cottrel dust to produce monocalcium phosphate on a production scale. The chemical composition of the resulting monocalcium phosphate was determined and confirmed by analytical methods. The proposed technology for producing monocalcium phosphate from cottrel dust is recommended for use in the agro-industrial complex.
Roles and Abilities of Academic and Research Librarians in Optimizing Access to Information: An Interpretative Analysis from the Romanian Librarians’ and Users’ Perspective
Authors: Popescu Elena , Madge Octavia-Luciana 
Published: June 2024

Abstract
This study addresses the role of Romanian academic and research librarians in optimizing access to information in the digital age, in relation to quality management and knowledge management. The novelty of this study consists in its parallel analysis of both librarians’ and users’ perspectives on librarians’ roles and abilities in optimizing access to information. The results obtained by means of interpretative qualitative analysis combined with descriptive quantitative analysis revealed that Romanian librarians succeed in providing good information services, however, the demands and expectations of users highlight a continuous need for integration of librarians into the mission of the universities and research institutes, and knowledge sharing and a series of innovations are recommended. The results obtained by interpretative analysis, combined with quantitative analysis for corroboration, point to four interrelated themes regarding the Romanian librarians’ roles and abilities in optimizing access to information. The first principal idea is that librarians’ abilities and competencies are key assets for Romanian academic and special research libraries. The second is that Romanian librarians need training in knowledge management and quality management. The third is that embedded librarianship and knowledge sharing could add quality to libraries services. Finally, the fourth is that competency management can determine engagement of Romanian librarians in improving access to information.
All-optical modulator with photonic topological insulator made of metallic quantum wells
Authors: Wang Haiteng , Niu Junru , Chen Qiaolu , Zhao Sihan , Shao Hua , Yang Yihao , Chen Hongsheng , Li Shilong , Qian Haoliang 
Published: June 2024

Abstract
All-optical modulators hold significant prospects for future information processing technologies for they are able to process optical signals without the electro-optical convertor which limits the achievable modulation bandwidth. However, owing to the hardly-controlled optical backscattering in the commonly-used device geometries and the weak optical nonlinearities of the conventional material systems, constructing an all-optical modulator with a large bandwidth and a deep modulation depth in an integration manner is still challenging. Here, we propose an approach to achieving an on-chip ultrafast all-optical modulator with ultra-high modulation efficiency and a small footprint by using photonic topological insulators (PTIs) made of metallic quantum wells (MQWs). Since PTIs have attracted significant attention because of their unidirectional propagating edge states, which mitigate optical backscattering caused by structural imperfections or defects. Meanwhile, MQWs have shown a large Kerr nonlinearity, facilitating the development of minimally sized nonlinear optical devices including all-optical modulators. The proposed photonic topological modulator shows a remarkable modulation depth of 15 dB with a substantial modulation bandwidth above THz in a tiny footprint of only 4 × 10 µm2, which manifests itself as one of the most compact optical modulators compared with the reported ones possessing a bandwidth above 100 GHz. Such a high-performance optical modulator could enable new functionalities in future optical communication and information processing systems.
Association Between the COI and Excess Health Care Utilization and Costs for ACSC
Authors: Maholtz Danielle , Page-Goertz Christopher K. , Forbes Michael L. , Nofziger Ryan A. , Bigham Michael , McKee Bryan , Ramgopal Sriram , Pelletier Jonathan H. 
Published: June 2024

BACKGROUND AND OBJECTIVES
The authors of previous work have associated the Childhood Opportunity Index (COI) with increased hospitalizations for ambulatory care sensitive conditions (ACSC). The burden of this inequity on the health care system is unknown. We sought to understand health care resource expenditure in terms of excess hospitalizations, hospital days, and cost.

METHODS
We performed a retrospective cross-sectional study of the Pediatric Health Information Systems database, including inpatient hospitalizations between January 1, 2016 and December 31, 2022 for children &lt;18 years of age. We compared ACSC hospitalizations, mortality, and cost across COI strata.

RESULTS
We identified 2 870 121 hospitalizations among 1 969 934 children, of which 44.5% (1 277 568/2 870 121) were for ACSCs. A total of 49.1% (331 083/674 548) of hospitalizations in the very low stratum were potentially preventable, compared with 39.7% (222 037/559 003) in the very high stratum (P &lt; .001). After adjustment, lower COI was associated with higher odds of potentially preventable hospitalization (odds ratio 1.18, 95% confidence interval [CI] 1.17–1.19). Compared with the very high COI stratum, there were a total of 137 550 (95% CI 134 582–140 517) excess hospitalizations across all other strata, resulting in an excess cost of $1.3 billion (95% CI $1.28–1.35 billion). Compared with the very high COI stratum, there were 813 (95% CI 758–871) excess deaths, with &gt;95% from the very low and low COI strata.

CONCLUSIONS
Children with lower neighborhood opportunity have increased risk of ACSC hospitalizations. The COI may identify communities in which targeted intervention could reduce health care utilization and costs.
Handgrip strength test for the diagnosis of long QT syndrome
Authors: Komoliatova V. N. , Makarov L. M. , Akopyan A. G. , Komarov A. N. , Aksenova N. V. , Besportochny D. A. 
Published: June 2024

Long QT syndrome (LQTS) assessment is based on the QT/ÖRR equation (the so-called Bazett's formula) and calculating the corrected QT (QTc). However, this formula reliably estimates the QT interval in the heart rate range (HR) of 60-90 bpm, which makes it difficult to diagnose LQTS in patients with sinus bradycardia, typical of this disease.Aim. To improve the LQTS diagnosis in patients with sinus bradycardia using the handgrip strength test.Material and methods. A total of 188 patients aged 5-53 years (16 [13;17]) were examined: group I — 40 healthy children aged 9-17 years (14 [12;16]); group II — 98 athletes with sinus bradycardia <60 bpm aged 16 [16;17] years; group III — 50 patients with LQTS aged 5-53 years (12 [10;16]). The handgrip strength test consisted of regular rhythmic compression of a hand expander with a resistance of 20 kg until the heart rate increased >60 bpm. The patients had an electrocardiogram recorded twice before and after the handgrip test. Heart rate, QT and QTc intervals were analyzed.Results. In all groups, after using the expander, there was a significant increase in heart rate, QT interval shortening and QTc interval prolongation. QTc interval prolongation after the handgrip test >460 ms was a highly sensitive marker of LQTS (Se 96%, Sp 60%).Conclusion. Proposed handgrip test for sinus bradycardia makes it possible to increase heart rate, which ensures a more correct use of the Bazett's formula for assessing the corrected QT interval (QTc). QTc interval prolongation over 460 ms after the handgrip test is a highly sensitive additional marker for identifying patients with LQTS.
PHYSIOLOGICAL PERFORMANCE OF SEEDS OF Phaseolus vulgaris L. AS A FUNCTION OF ZINC AND PHYSIOLOGICAL MATURITY
Authors: Lima Paula Aparecida Muniz de , Oliveira Cabral Mateus , Henrique da Silva Pedro , Dias Alixandre Ricardo , Rosa de Lisbôa Jacomino Gardênia , De Oliveira Lopes Simone , Sobreira Alexandre Rodrigo , Lopes José Carlos 
Published: June 2024

The objective of this study was to study the physiological quality of bean treated with levels of zinc during the physiological maturation stage. The work was carried out at Fazenda Ponte da Braúna and at the Seed Analysis Laboratory of the Center for Agricultural Sciences and Engineering at the Federal University of Espírito Santo. Bean seeds of the cultivar Peanut were treated with Zn at concentrations of 0; 2.5; 5.0; 7.5 and 10 g kg-1 of seeds and sown in the field. The variables analyzed were seed moisture, 1000-seed weight, length, width and thickness of pods and seeds, germination, germination speed index, shoot length, root length, shoot and root dry matter. The experimental design used was completely randomized, in the factorial 5 x 7 (zinc doses x maturation periods), with four replications of 25 seeds. The seeds of the bean cultivar Amendoim treated with zinc at 10 g kg-1 seeds showed the highest values of pod length, thickness, and width. The seeds of the bean cultivar Amendoim showed the highest germination means and GSI after 35 days from anthesis. The treatment of seeds of the bean cultivar Amendoim with zinc does not influence the seedling characteristics. Seed treatment with zinc does not interfere with the seed maturation time of the bean cultivar Amendoim. The physiological maturation of seeds of the bean cultivar Amendoim occurs after 42 days from anthesis. The seed water content of the bean cultivar Amendoim at the stage of physiological maturation is 19%
Assessment of antimicrobial activity of Meliponula ferrugica in pathogenic wound samples
Authors: Rajayan Jasmin Sajini , Rangasamy Naveen , Narayan Niranjan Lakshmi , George Vijila Helen Mary , Rajendran Karthik 
Published: June 2024

Background: Honey is a naturally occurring sweet material that bees make from nectar from flowers, secretions from plant parts, or excretions from plants that suck insects from plant parts. Honey’s antibacterial and antifungal qualities are widely known, and it has been used to heal burns, surgical wounds, and decubitus ulcers. Honey instantly sterilizes wounds affected by Staphylococcus aureus. The honey’s ability to fight bacteria can be ascertained by the nectar’s origin. Many antibiotic resistances among the bacteria that cause infections in humans have directly evolved as a result of the use of antibiotics in clinical practice.
Methods: This study found that Bergey’s manual of determinative bacteriology can be used to identify Pseudomonas aeruginosa and Staphylococcus aureus. According to the study’s findings, honey has a capacity to neutralise Pseudomonas aeruginosa and Staphylococcus aureus that have been isolated from infected wounds. Honey’s antibacterial characteristics account for a significant portion of its antibacterial activity.
Results: Staphylococcus aureus and Pseudomonas aeruginosa were both susceptible to the antibacterial activity of the honey sample. Pseudomonas aeruginosa exhibited lower activity compared to Staphylococcus aureus.
Conclusions: The results of this investigation show that Bergey’s handbook of determinative bacteriology can be used to identify Staphylococcus aureus and Pseudomonas aeruginosa. According to the study’s findings, honey has the ability to neutralise Pseudomonas aeruginosa and Staphylococcus aureus that have been isolated from infected wounds.
Expert opinion on the prescription practice of vildagliptin and its combinations in managing type 2 diabetes mellitus in Indian settings
Authors: S. Manjula , M. Krishna Kumar 
Published: June 2024

Background: The aim of the study was to gather expert opinion regarding the use of vildagliptin and its combinations in T2DM in Indian settings.
Methods: This cross-sectional study involved 24 questions and collected perspectives of experts across various clinical settings in India regarding the use of vildagliptin and its combinations for the management of type 2 diabetes mellitus (T2DM) in their clinical practice.
Results: Among 195 participants, most clinicians (73%) advocated vildagliptin once-daily formulation for newly diagnosed young diabetics, elderly patients with long-standing diabetes, and those with uncontrolled diabetes as an add-on therapy. Around 92% favored vildagliptin for its weight-neutral nature, preservation of beta-cell function, minimal glycemic variation, and low risk of adverse effects. Most clinicians (66%) preferred initiating vildagliptin and metformin combination therapy in diabetic individuals aged 40 to 50 years, with 53% opting for it when HbA1c levels exceeded 8%. Approximately 83% favored this combination for young, elderly, and long-standing diabetic individuals. More than half (54%) of the clinicians preferred prescribing the fixed-dose combination (FDC) of vildagliptin and dapagliflozin to 11-25% of the patients.
Conclusions: The survey underscored the effectiveness of vildagliptin and its combinations in managing T2DM. Clinicians widely endorsed vildagliptin once-daily formulation and vildagliptin and metformin therapy for diverse diabetic populations due to their efficacy and tolerability. They also advocated the use of vildagliptin and dapagliflozin therapy, especially in patients with specific comorbidities or higher HbA1c levels, citing its benefits in achieving better glycemic control and reducing disease progression.