bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening
Authors: Aschenbrenner Jasmin C. , de Godoy Andre Schutzer , Fairhead Michael , Tomlinson Charles W.E. , Winokan Max , Balcomb Blake H. , Capkin Eda , Chandran Anu V. , Golding Mathew , Koekemoer Lizbe , Lithgo Ryan M. , Marples Peter G. , Ni Xiaomin , Thompson Warren , Wild Conor , Xavier Mary-Ann E. , Fearon Daren , von Delft Frank 
Published: August 2024

AbstractChikungunya virus (CHIKV) causes severe fever, rash and debilitating joint pain that can last for months1,2or even years. Millions of people have been infected with CHIKV, mostly in low and middle-income countries, and the virus continues to spread into new areas due to the geographical expansion of its mosquito hosts. Its genome encodes a macrodomain, which functions as an ADP-ribosyl hydrolase, removing ADPr from viral and host-cell proteins interfering with the innate immune response. Mutational studies have shown that the CHIKV nsP3 macrodomain is necessary for viral replication, making it a potential target for the development of antiviral therapeutics. We, therefore, performed a high-throughput crystallographic fragment screen against the CHIKV nsP3 macrodomain, yielding 109 fragment hits covering the ADPr-binding site and two adjacent subsites that are absent in the homologous macrodomain of SARS-CoV-2 but may be present in other alphaviruses, such as Venezuelan equine encephalitis virus (VEEV) and eastern equine encephalitis virus (EEEV). Finally, a subset of overlapping fragments was used to manually design three fragment merges covering the adenine and oxyanion subsites. The rich dataset of chemical matter and structural information discovered from this fragment screen is publicly available and can be used as a starting point for developing a CHIKV nsP3 macrodomain inhibitor.
Breastmilk IgG engages the neonatal immune system to instruct host-microbiota mutualism
Authors: Shenoy Meera K. , Rico Diane , Gordon Shannon , Milburn Luke , Schwensen Jeanette , Cabàn Madelyn , Koch Meghan A. 
Published: August 2024

AbstractMaternal antibodies fundamentally regulate infant immunity to the developing gut microbiota, yet the mechanisms underlying this process remain elusive. Here, we show that maternal IgG, ingested in the first week of life, functions to restrain microbiota-dependent adaptive immune responses and reduce offspring susceptibility to intestinal inflammation weeks later, following weaning. To exert these functions, efficient binding of IgG to gut bacterial antigens and engagement of Fc and complement dependent effector functions in offspring was required. These discoveries reveal a novel mechanism wherein maternal IgG engages the offspring immune system to calibrate responses to gut microbes. This mode of maternal immune instruction may provide adaptability to developmental shifts in microbiota necessary for establishing host-microbiota mutualism and limiting susceptibility to inflammatory disease.One sentence abstractIngestion of maternal IgG during a discrete postnatal window calibrates neonatal immunity to the gut microbiota.
Consumption value and context-specific attributes: the moderating effect of social class on Halal cosmetics purchase intention
Authors: Liew Christine Wan Shean , Ramayah T. , Karia Noorliza 
Published: August 2024

PurposeThe purpose of this study is to examine factors influencing consumers’ intention to purchase Halal cosmetics through the lens of theory of consumption values (TCV).Design/methodology/approachThis study employed a quantitative research methodology, collecting data from 185 respondents through an online questionnaire. The participants, selected via purposive sampling, were all current purchasers of cosmetics. The data were analyzed using partial least square structural equation modeling (PLS-SEM) with the assistance of IBM SPSS and SmartPLS software.FindingsThis research reveals that emotional value is the most substantial value predictor, followed by epistemic value, conditional value and functional value. Further, the moderation analysis shows that the effect of conditional value is strengthened when the consumer are from a higher social class.Originality/valueThis study reveals that consumption values with context-specific attributes directly impact consumer purchase intentions towards Halal cosmetics, while social class acts as a significant catalyst. This offers a fresh perspective that mitigates the traditional misconceptions about Halal cosmetics among Malaysians, highlighting the complexity and resilience of consumer adoption in this innovative sector.
Designing business analytics (BA) platforms: tracing the visual redesign process of a startup’s BA platform
Authors: Griva Anastasia , Karagiannaki Angeliki 
Published: August 2024

Purpose Designing effective business analytics (BA) platforms that visualise data, provide deep insights and support data-driven decision-making is a challenging task. Understanding the elements shaping BA platform design is crucial for success. The purpose of this study is to explore the impact of visualisation on usability (UI) and user experience (UX) while emphasising the importance of insights understanding in BA platform design.Design/methodology/approach This paper presents a case study following a startup’s journey as it undergoes two redesign phases for its BA platform. A combination of quantitative and qualitative methods is used to assess UX/UI and insights understanding of the platform. Indicatively this included semi-structured interviews, observations, think-aloud techniques and surveys to monitor runtime per task, number of errors, users’ emotions and users’ understanding.Findings Our findings suggest that modifications in aesthetics and information visualisation positively influence overall usability, UX, and understanding of platform insights – a critical aspect for the success of the startup.Research limitations/implications Our goal is not to make a methodological contribution, but to illustrate how companies, constrained by time and pressure, navigate platform changes without meticulous design and provide learnings on important elements while designing BA platforms.Practical implications This paper concludes with suggested methods for assessing BA platforms and recommends practical practices to follow. These practices include recommendations on important elements for BA platform users, such as navigation and interactivity, user control and personalisation, visual consistency and effective visualisation.Originality/value This study contributes to practice as it presents a real-life case and offers valuable insights for practitioners.
Towards better governance: creating a corporate governance index for South African firms
Authors: Naidu Delane Deborah , McCullough Kerry , Peerbhai Faeezah 
Published: August 2024

Purpose
The purpose of this study is to construct a robust index and subindices to measure the quality of corporate governance for 266 firms listed in South Africa from 2004 to 2021.

Design/methodology/approach
Public information on the compliance of King Code of Good Corporate Governance is used to construct a main index predicated on provisions relating to board characteristics, accounting and auditing and risk management. These categories are transformed into three subindices. All constructs are scored with binary coding and equally weighted.

Findings
Cronbach’s alpha test reveals that the index and subindices are highly reliable measures of corporate governance. The principal component analysis supports the construct validity of all measures.

Research limitations/implications
The index is limited to only three corporate governance subcategories and only focuses on South Africa.

Practical implications
These corporate governance indices provide governing authorities, policymakers, investors and other market participants direct information on the quality of corporate governance in South African firms.

Originality/value
As South Africa lacks a formal corporate governance indicator, the development of an appropriate corporate governance index and subindices contributes towards understanding the quality of corporate governance in South African firms. To the best of the authors’ knowledge, this is the first paper to conduct robustness tests on corporate governance indices designed for South African companies.
WOW Skin Science: strategic adaptation for responsible advertising
Authors: Kanaveedu Aswathi , Kalapurackal Jacob Joseph , N. Elangovan , Sinha Mudita , Nagpal Mayank 
Published: August 2024

Learning outcomes
After completing this case study, students will be able to understand the issues firms, brands and influencers face due to sponsorship disclosure regulation and the impact of self-regulation on firms engaging in influencer marketing, explain the challenges regulators face in ensuring compliance in an emerging market, explain Advertising Standard Council of India (ASCI)’s challenges in adopting influencer guidelines from emerged markets and recommend ethical theory (or theories) and strategies to firms engaged in influencer marketing.

Case overview/synopsis
This case study centers on Mr Manish Chowdhary, co-founder of WOW Skin Science, who started the beauty and personal care business with his brother Karan Chowdhary in 2015 in Bangalore, India. The company successfully built its brand through influencer marketing but faced challenges after the ASCI implemented new influencer guidelines. On May 31, 2021, he expressed disagreement with ASCI guidelines during an interview with Akansha Nagar from Buzz in Content, particularly the requirement to label every product or service received by influencers as an advertisement. He expressed concern about certain rules, fearing they might harm organic content and reduce viewership and followers. Subsequently, ASCI registered noncompliance cases against the company and communicated with them about complaints regarding influencer guideline violations. In this situation, Manish needed to evaluate his decision on noncompliance with regulation and required an action plan to strategically manage its influencer marketing campaign by incorporating ASCI’s guidelines. Overall, this case study highlights the journey of WOW Skin Science and its challenges with self-regulatory authorities over its influencer marketing strategy in an emerging market. Additionally, students can gain insight into the marketing communication ethics of a startup operating in an emerging market by embodying the protagonist’s role.

Complexity academic level
This case study is suitable for postgraduate level students pursuing a Master of Business Administration program. The difficulty level ranges from moderate to complex. It fits well into integrated marketing communication and marketing strategy courses. This case study discusses marketing ethics, advertising and promotion regulation.

Supplementary materials
Teaching notes are available for educators only.

Subject code
CSS 8: Marketing.
Re-envisioning vocational education: critical discourse analysis of a government publicity campaign in Hong Kong
Authors: Chan Kara , Zhang Jasmine 
Published: August 2024

PurposeVocational education in Hong Kong suffers from an image problem. Stakeholders often perceive it as a second-best option for those who fail to advance in academic education. In 2016, to promote vocational education, the Hong Kong government launched a publicity campaign and rebranded vocational education and training (VET) as vocational and professional education and training (VPET). This study critically analyzes the new discourse crafted by this campaign and assesses its potential to change VPET’s status.Design/methodology/approachThis study applies critical discourse analysis to the set of television public service advertisements produced as part of the government publicity campaign.FindingsThe messaging of the publicity campaign consists of two major discursive strategies. One stresses the ability to find self-fulfillment through VPET. The other stresses the academic ability and middle-class status of VPET students as well as the non-manual and high-end career opportunities for graduates. While the first strategy offers a new basis on which to value VPET, the second recreates assumptions about the value of academic achievement and what constitutes respectable employment, even as it attempts to challenge stereotypes. It reinforces that the ultimate goal of education is financial gain and social status. It overlooks other values of education and the potential value of VPET in enhancing individual choice and agency.Research limitations/implicationsDiscourse analysis does not provide information about audience perceptions and interpretations.Social implicationsThe government could consider reframing their messaging in terms of the diverse values and experiences of VPET students. Highlighting the values that VPET students themselves see in their education provides alternative discourses that can better challenge hegemonic ideas.Originality/valueTo the best of our knowledge, this is the first discourse analysis of the government’s publicity campaign to promote VPET.
Assessment of the impact of intellectual capital development on firm development: an ISM approach
Authors: Behera Manasee , Mishra Rohita Kumar 
Published: August 2024

Purpose
The paper aims to determine how intellectual capital development mediators aid in the development of the company. Intellectual capital management (ICM) enhancers are difficult to measure, yet there is enough information available to assess how they affect the development of an organization.

Design/methodology/approach
The following queries have been covered in this paper: What are the essential components that make up a firm's development? What part do ICM facilitators play in the development of the company? A methodical analysis of the literature was used to determine the ICM facilitators that propel the growth of the organization. To determine the crucial components of ICM effectiveness, a survey-based questionnaire was sent to a variety of employees in the public and private sectors of Indian organizations.

Findings
The interpretive structural modeling (ISM) provides information on the degree of involvement and illustrates how facilitators impact one another. In this paper, the ICM strategy is described in general terms and how businesses can use it for the development of the firms that boosts productivity and efficiency. The significance of human, structural and relational capital (RC) in Indian enterprises is examined in this paper. In addition to human capital, structural capital and relational capital, organizational culture, innovation and learning are all essential for putting ICM practices into practice. Specifically, these elements directly affect a business's ability to gain a competitive advantage, grow and improve organizational performance and ultimately the development of the firms.

Research limitations/implications
The profiles of the respondents and the organizations to which they belong must be taken into consideration when interpreting the research's conclusions and findings. The respondents are limited to Indian organizations only.

Practical implications
ICM facilitators can reduce the number of complaints from customers and increase their satisfaction with the goods and services provided by Indian firms. ICM efforts may also be redirected into innovation to raise the quality of goods and services.

Originality/value
To improve firm development, experts who develop and implement ICM systems and processes in their respective fields might find this study useful in identifying the facilitators and developing a suitable plan for the methodical growth of intellectual capital that makes use of ISM.
Perceptions of different communication strategies on proenvironmental waste disposal behavior: a case study with university students in Brazil
Authors: Maris Lima Cruz Cassiana , Bosa Igor Grotto , Kolling Camila , de Medeiros Janine Fleith , Ribeiro José Luís Duarte 
Published: August 2024

Purpose
This study aims to understand the perception of young people regarding different communication strategies to promote proenvironmental disposal behavior. Based on the attention-interest-desire-action (AIDA) model, the study analyses how university students react to different communication approaches used by a university aiming at the correct disposal of waste.

Design/methodology/approach
The authors conducted a qualitative exploratory research in two steps: (i) a narrative bibliographic review and (ii) a case study. The (i) bibliographic review was conducted about proenvironmental behavior and disposal of solid waste and response hierarchy models, with emphasis on the AIDA model. The (ii) case study was executed through an in-depth interview with a manager of the environmental sanitation area and a qualitative survey with undergraduate students from a university in southern Brazil.

Findings
The findings reveal that young people tend to prefer communication strategies related to triggers for long-term memory, especially when evaluating the cognitive stage of the response hierarchy. For example, the provision of bins identified with stickers and colors is a communication strategy that leads to a memory model of associative networks. By viewing a certain color or image of an object, the individual can quickly retrieve information already known about the act of properly disposing of waste. Additionally, convenience is a key factor for the behavioral intention of properly disposing of waste to become a reality.

Originality/value
Few studies have identified the most effective communication strategies to promote proper disposal behavior among young people in universities. This study addresses this gap, based on the AIDA model.
Hybrid religious civil society organization, the Israeli case of “the path upwards” lesson learned
Authors: Moskovich Yaffa , Binhas Adi 
Published: August 2024

PurposeThis study aims to investigate the unique cultural attributes of a particular association. The research focuses on a single case study involving a civil society organization whose activities are focused within the Israeli Defense Forces (IDF). Specifically, the association under examination is a religious voluntary organization engaged in social activities within the Israeli Defense Forces.Design/methodology/approachData collection employed a qualitative approach using the case study method, with twenty in-depth ethnographic interviews conducted. The research questions guiding the study are: What are the hybrid structural characteristics of the religious association? How has this hybrid structure influenced the organizational culture?FindingsThe study identifies a hybrid structure comprising community, familial, and bureaucratic features. It reveals a blend of clan and bureaucratic cultural elements within the organization, demonstrating adaptability to the ideology of the Israeli Defense Forces.Originality/valueThe research uncovers an innovative hybrid structure that successfully navigates bureaucratic challenges and fosters a familial atmosphere contributing to communal benefits.
Fraud risk of sovereign wealth funds: fraud triangle and agency theory perspectives
Authors: Lootah Manar , Gleason Kimberly , Smith Deborah , Zoubi Taisier 
Published: August 2024

Purpose
The purpose of this paper is to examine failures in internal and external controls associated with sovereign wealth funds (SWFs), using three caselets to illustrate the fraud triangle theory factors.

Design/methodology/approach
This study uses a qualitative research approach. Caselets are used to illustrate the fraud triangle factors associated with SWFs.

Findings
Ideally, SWFs would be characterized by opacity and the strategic flexibility to advance political goals, but this operational agility facilitates an environment ripe for fraud, in large part because there is little transparency with regard to their regulatory structure. Elements of the fraud triangle inherent in the structure of SWFs contribute to the fraud found in the three case examples.

Research limitations/implications
The authors use three SWF fraud cases rather than statistical sampling of all SWFs, which limits the generalizability of the findings. Future research should explore additional recommendations for the evaluation of SWF governance.

Practical implications
The overlap between public sector governance and SWF governance creates an environment amenable to fraud, and as a result, fraud has occurred in several SWFs. Governance recommendations should take into account the lessons learned from previous SWF fraud cases.

Social implications
Ideally, SWFs would be characterized by opacity and the strategic flexibility to advance political goals, but this operational agility may also facilitate an environment ripe for fraud, in large part because there is little transparency with regard to their regulatory structure.

Originality/value
To the best of the authors’ knowledge, this paper is the first to identify the fraud triangle risk factors associated with sovereign wealth funds using SWF fraud caselets.
Anthropomorphism-based artificial intelligence (AI) robots typology in hospitality and tourism
Authors: Saputra Fachri Eka , Buhalis Dimitrios , Augustyn Marcjanna M. , Marangos Stefanos 
Published: August 2024

Purpose
Anthropomorphism plays a crucial role in the deployment of human-like robots in hospitality and tourism. This study aims to propose an anthropomorphism-based typology of artificial intelligence (AI) robots, based on robot attributes, usage, function and application across different operational levels.

Design/methodology/approach
Following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist, the research was conducted in two stages. A search strategy was implemented to explore anthropomorphism-based AI robots and to develop a robot typology.

Findings
This study provides a comprehensive typology of anthropomorphism-based AI robots used in tourism and hospitality and classifies them into four types, namely, chatbots, mechanoids, humanoids and android robots. Each type features distinct functions and applications.

Practical implications
The findings can assist companies in using anthropomorphic robots to improve service and strengthen competitiveness. This study offers valuable insights to managers for deploying AI robots across diverse service sectors.

Originality/value
This research provides a novel typology of hospitality and tourism AI robots and extends the understanding of anthropomorphism in human–robot interaction. This typology encompasses both virtual and physical robots, providing clarity on their attributes, usage, functions and applications across diverse areas of hospitality operations.