bluuebunny/crossref_metadata_2025_split huggingface dataset:
Runx1-Mediated Regulation of Osteoclast Differentiation and Function
Authors: Soung Do Y. , Kalinowski Judith , Baniwal Sanjeev K. , Jacome-Galarza Christian E. , Frenkel Baruch , Lorenzo Joseph , Drissi Hicham 
Published: March 2014

Abstract
Excessive bone resorption is the cause of several metabolic bone diseases including osteoporosis. Thus, identifying factors that can inhibit osteoclast formation and/or activity may define new drug targets that can be used to develop novel therapies for these conditions. Emerging evidence demonstrates that the master regulator of hematopoiesis, Runx1, is expressed in preosteoclasts and may influence skeletal health. To examine the potential role of Runx1 in osteoclast formation and function, we deleted its expression in myeloid osteoclast precursors by crossing Runx1 floxed mice (Runx1F/F) with CD11b-Cre transgenic mice. Mice lacking Runx1 in preosteoclasts (CD11b-Cre;Runx1F/F) exhibited significant loss of femoral trabecular and cortical bone mass compared with that in Cre-negative mice. In addition, serum levels of collagen type 1 cross-linked C-telopeptide, a biomarker of osteoclast-mediated bone resorption, were significantly elevated in CD11b-Cre;Runx1F/F mice compared with those in Runx1F/F mice. Tartrate-resistant acid phosphatase–positive osteoclasts that differentiated from bone marrow cells of CD11b-Cre;Runx1F/F mice in vitro were larger, were found in greater numbers, and had increased bone resorbing activity than similarly cultured cells from Runx1F/F mice. CD11b-Cre;Runx1F/F bone marrow cells that were differentiated into osteoclasts in vitro also had elevated mRNA levels of osteoclast-related genes including vacuolar ATPase D2, cathepsin K, matrix metalloproteinase 9, calcitonin receptor, osteoclast-associated receptor, nuclear factor of activated T cells cytoplasmic 1, and cFos. These data indicate that Runx1 expression in preosteoclasts negatively regulates osteoclast formation and activity and contributes to overall bone mass.
Remediation as Pharmikon
Authors: Medovoi Leerom 
Published: March 2014

As an environmental term, “remediation” converges with “sustainability,” “resilience,” and “greening” to evoke an ethically positive resolution to ecological crisis and suggest the restoration of some nearly lost vitality through the neutralization of its afflictions. Although this primary sense of “remediation” might seem unrelated to Jay Bolter and Richard Grusin's use of that word to describe certain paradigmatic representational strategies of new media, where the environment is concerned, these two etymologies ultimately converge: to remediate is to re-present the environment that once existed prior to the affliction so as to make that affliction appear curable. In the process, remediation completes a circuit of “afflicting” power. To the extent that the medical conception underlying “environmental remediation” approximates the Greek ϕἀρμακον, or Pharmikon, Derrida's underlying point in “Plato's Pharmacy” also applies: environmental remediation is itself a dissimulating text whose remedial promise both conceals and depends upon its constitutive other, its equal potency as an environmental poison.
I investigate these issues by first suggesting that the promise of remediation for environmental sites that receive extensive media coverage (the Gulf, for example) may help ensure the absence of remediation in environments largely invisible to the global “media” (the Niger Delta). I also suggest that a fully self-aware pharm-eco-criticism would take special pains to consider when and how the valorization of nature might have differential yet tightly related geopolitical effects, under certain circumstances even serving as a screen for postcolonial violence and corporate-driven damage. The essay concludes with an analysis of Halon Habil's Oil on Water in order to argue that, if there is to be a mode of ecocriticism whose critical sophistication might lead to a vision of meaningful remediation, it will need to maintain a vigilant wariness about elixirs whose promise to protect us from a brush with death actively serves to distract us from some fresh round of postcolonial toxicity.
Photochemical Generation of Superbases from Carboxylates Consisting of Phthalimidoacetic Acid Derivatives and Superbases
Authors: Arimitsu Koji , Fukuda Ken , Sakai Nobuhiko 
Published: March 2014

Abstract
We have developed simple and powerful photobase generators capable of highly efficient production of superbases. These photobase generators were prepared by simply mixing phthalimidoacetic acid derivatives with the corresponding superbases. The use of photobase generators enabled anionic UV curing at lower temperatures, in contrast to previous anionic UV curing materials that required heat treatment above 150 °C after UV irradiation. The cured films showed no volume shrinkage.
Wallflowers: Experimental Evidence of an Aversion to Standing Out
Authors: Jones Daniel , Linardi Sera 
Published: March 2014

An extensive literature on reputation signaling in prosocial settings has focused on an intrinsic desire for positive reputation. In this paper, we provide experimental evidence that some individuals are averse to both positive and negative reputation and will therefore respond to visibility by signaling that they are an “average altruism type” relative to their audience. We formalize our hypotheses about “wallflower” behavior in a theoretical model. Our experimental results show that instead of uniformly increasing contributions, visibility draws contributions toward the middle of others' contributions. As a result, visibility is associated with higher levels of giving only in scenarios where others are giving a large amount. We also observe heterogeneity in reputation concerns: wallflower behavior is particularly strong for women and can be observed in several different settings. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2013.1837 . This paper was accepted by Uri Gneezy, behavioral economics.
Timing Ability of Government Bond Fund Managers: Evidence from Portfolio Holdings
Authors: Huang Jing-Zhi , Wang Ying 
Published: March 2014

This study examines the ability of government bond fund managers to time the bond market, based on their monthly or quarterly holdings of Treasury securities during the 1997–2006 period. We find that, on average, government bond funds exhibit significantly positive timing ability at the one-month horizon under an unconditional holdings-based timing measure. However, our results indicate that managers' actions based on public information can explain the documented positive timing ability—namely, the average government bond fund has neutral or even slightly negative conditional market timing ability once public information is controlled for. Nonetheless, we find evidence that fund managers specializing in Treasury securities can better interpret public information than general government bond fund managers do. This paper was accepted by Wei Xiong, finance.
Raloxifene pharmacodynamics is influenced by genetic variants in the RANKL/RANK/OPG system and in the Wnt signaling pathway
Authors: Mencej-Bedrač Simona , Zupan Janja , Mlakar Simona Jurković , Zavratnik Andrej , Preželj Janez , Marc Janja 
Published: March 2014

Abstract

Background: Raloxifene is a selective estrogen receptor (ER) modulator (SERM) used for the treatment of osteoporosis. However, its efficacy and also its safety vary greatly among treated patients, and it might be influenced by the individuals’ genetic background. As the receptor activator of the nuclear factor κB (RANK) ligand (RANKL)/RANK/osteoprotegerin (OPG) system is essential for osteoclastogensis and Wnt signaling pathway for osteoblastogenesis, we decided to evaluate the raloxifene treatment in regard to selected polymorphisms in key genes of these two main bone regulatory pathways.

Methods: Fifty-six osteoporotic postmenopausal women treated with raloxifene were genotyped for 11 polymorphisms located in six genes: -290C>T, -643C>T, and -693G>C in tumor necrosis factor receptor superfamily member 11 (TNFSF11), +34694C>T, +34901G>A, and +35966insdelC in tumor necrosis factor receptor superfamily member 11A (TNFRSF11A), K3N and 245T>G in tumor necrosis factor receptor superfamily member 11B (TNFRSF11B), A1330V in LRP5, I1062V in LRP6, and -1397_-1396insGGA in SOST. For evaluation of treatment efficacy, bone mineral density (BMD) and biochemical markers of bone turnover were measured.

Results: One-year change in total hip BMD was associated with +34901G>A in TNFRSF11A (p=0.040), whereas, for lumbar spine BMD, the association was shown for -1397_-1396insGGA in SOST (p=0.015). C-terminal crosslinking telopeptides of type I collagen (CTX) concentrations showed significant association with -643C>T single nucleotide polymorphism (SNP) in TNFSF11 (p=0.049) and +34694C>T in TNFRSF11A (p=0.022). No other association was found between 1-year change in BMDs or biochemical markers and the studied SNPs.

Conclusions: We have shown that, in postmenopausal osteoporotic women treated with raloxifene, the efficacy of raloxifene treatment might be influenced by +34901G>A in TNFRSF11A gene and -1397_-1396insGGA in the SOST gene as well as -643C>T in TNFSF11 gene and +34694C>T in TNFRSF11A gene. However, these findings need additional functional and clinical confirmation for potential pharmacogenetic use in the future.
Evaluating Preceptor Perception of Support Using Educational Podcasts
Authors: Blum Cynthia A. 
Published: March 2014

AbstractAfter their initial training, preceptors report a lack of ongoing support specifically in dealing with preceptor-identified areas of unsafe practice: the inability to demonstrate knowledge and skills, attitude problems, unprofessional behavior, and poor communication skills. The purpose of this staff development study was to test the use of educational technology in the form of podcasts, demonstrating how a preceptor could constructively approach difficult situations using caring behaviors to engage novice nurses and to examine the relationship between preceptor support and role commitment. A correlational research design was used to examine the effects of the podcasts, continuously available through common web sites. Findings include a significant increase in the preceptor’s perception of support especially among participants who had less training or experience with precepting. A strong correlation between the preceptor’s perception of support and commitment to their role was also demonstrated. Preceptors suggest development of additional podcasts for ongoing educational support.
The Power of Giving Feedback: Outcomes from Implementing an Online Peer Assessment System
Authors: Phillips Fred 
Published: March 2014

ABSTRACT
This paper describes an online system that facilitates peer assessment of students' course work and then uses data from individual case writing assignments in introductory financial accounting to empirically examine associations between peer assessment and case writing performance. Through this description and empirical analysis, the paper addresses the following questions: (1) Why use peer assessment? (2) How does online peer assessment work? (3) Is student peer assessment reliable? (4) What do students think of peer assessment? (5) Does student peer assessment contribute to academic performance? Three key findings from this study are that students at the sophomore level were able to generate reasonably reliable feedback for peers, they valued the experiences involved in providing peer feedback, and giving quality feedback had a more significant and enduring impact on students' accounting case analyses than did receiving quality feedback, after controlling for differences in accounting knowledge and case writing skills.
Clinical and Statistical Study on Canine Impaction
Authors: Adina-Simona Coșarcă , Mariana Păcurar , Monica-Cristina Nagy-Bota , Alina Ormenișan 
Published: March 2014

Abstract Aim: The aim of this study was to perform a clinical and statistical research on permanent impacted canine patients among those with dental impaction referred to and treated at the Oral and Maxillo-Facial Surgery Clinic of Tîrgu Mureș, over a four years period (2009-2012). Materials and methods: The study included 858 patients having dental impaction, and upon clinical records, different parameters, like frequency, gender, age, quadrant involvement, patient residence, associated complications, referring specialist and type of treatment, related to canine impaction, were assessed. Results: The study revealed: about 10% frequency of canine impaction among dental impactions; more frequent in women, in the first quadrant (tooth 13); most cases diagnosed between the age of 10-19 years; patients under 20 were referred by an orthodontist, those over 20 by a dentist; surgical exposure was more often performed than odontectomy. Conclusions: Canine impaction is the second-most frequent dental impaction in dental arch after third molars; it occurs especially in women. Due to its important role, canine recovery within dental arch is a goal to be achieved, whenever possible. Therefore, diagnose and treatment of canine impaction requires an interdisciplinary approach (surgical and orthodontic)
Rectal Cancer - Sphincter Saving Techniques
Authors: C Russu , C Molnar , C Pantiru , C Sărăcuț , M Gherghinescu , S Voidăzan , C Copotoiu 
Published: March 2014

Abstract
Background: Rectal cancer management has as its main component the surgical treatment. The purpose of the paper is to point out the advantages and disadvantages of sphincter saving techniques, respecting the oncological principles. Material and method: A cross-sectional, retrospective study was performed on a group of 69 patients admitted and surgically treated for rectal cancers in the Surgical Clinic I of the County Emergency Clinical Hospital of Tîrgu Mureș, for a period of one year (April 2012 - April 2013) and to whom rectal resections were performed. We followed the immediate postoperative evolutions in these patients, making a comparative analysis between those with the sphincter saving surgery and those in which other operations were performed. Results: From the total of 69 patients diagnosed with rectal cancer, sphincter saving procedures with restoration of digestive continuity by coloanal anastomosis were performed in 12 patients (17.39%) using the peranal or transanal approach; in 42 patients (60.86%) anterior rectosigmoidian resections with low and very low colorectal anastomosis („very low” Dixon procedure) were performed. In 15 cases (21.74%) the Miles type of rectal resections, using the abdomino-perineal way, were performed. Out of the 12 cases with peranal or transanal anastomosis, 4 cases had postoperative complications. Conclusions: Rectal resection procedures, which are restoring the digestive tract continuity using low anastomosis (colorectal, coloanal, peranal or transanal), are representing viable and „physiological” alternatives, if they respect the oncologic principles. In well selected cases, the immediate postoperative evolution is favorable, relieving the patient from the psychological and physical trauma due to the presence of a colostomy
Coefficient, distortion and growth inequalities for certain p-valent close-to-convex functions
Authors: Bapana I.B. , Handwana Sneha 
Published: March 2014

Abstract
In the present paper, we introduce and investigate a new subclass χtp(γ) of analytic and p-valent close-to-convex functions in the open unit disk U. For functions belonging to the class χtp(γ), some interesting properties including the coefficient estimates, distortion theorems and subordination results are obtained
Can we combine structural functionality and landscape services assessments in order to estimate the impact of landscape structure on landscape services?
Authors: Skokanová Hana 
Published: March 2014

Abstract
This paper investigates two methods of assessing structural functionality and landscape services, and the potential of their joint application in order to estimate the impact of landscape structure in terms of structural functionality on landscape capacity to provide various services. The methods were tested in three different landscape types of the Czech Republic. The results showed that linking these two methods might help in estimating the impact of landscape structure on some landscape services in landscape types with a prevalent valuable matrix, but are dependent on landscape metrics defining individual functionality groups
Co-Occurrence of Substance use Disorders with other Psychiatric Disorders: Implications for Treatment Services
Authors: Morisano Dominique , Babor Thomas F. , Robaina Katherine A. 
Published: March 2014

Introduction This paper critically evaluates the literature on the co-occurrence of substance-use disorders (SUDs) with other psychiatric conditions. Our review considers the variety of different associations between the two, and suggests the implications of the literature for the design of treatment services that address both types of disorders. Methods: A narrative review of research and theory was conducted, covering epidemiology of co-occurring psychiatric disorders worldwide, mechanisms underlying co-occurrence, and treatment models. Results: Epidemiological research has documented a high prevalence of co-occurring disorders in both clinical samples and the general population, although the literature is based primarily on studies in high-income countries and some of the overlap might be due to the co-occurrence of milder forms of both types of disorders. Consistent with what has been reported in other reviews, we conclude that clients with co-occurring disorders tend to have a more severe course of illness, more severe health and social consequences, more difficulties in treatment, and worse treatment outcomes than clients with a single disorder; we address the implications of these findings for the design of treatment services. Conclusions: Much of the evidence shows that separately, treatments for both SUD and other psychiatric disorders are effective in reducing substance use and in improving behavioral, familial, and psychosocial outcomes. The evidence further suggests that these outcomes might be improved when treatment modalities are offered in combination within an integrated treatment plan that simultaneously addresses substance abuse and psychiatric problems. It is concluded that there is potentially more to be gained from taking a public health perspective and working on efforts to implement existing evidence-based practices at the systems level, than from the current tendency to look for ever more powerful individual-level interventions at the clinical level.
The closures of arithmetic progressions in the common division topology on the set of positive integers
Authors: Szczuka Paulina 
Published: March 2014

Abstract
In this paper we characterize the closures of arithmetic progressions in the topology T on the set of positive integers with the base consisting of arithmetic progressions {an + b} such that if the prime number p is a factor of a, then it is also a factor of b. The topology T is called the common division topology.
Sol-gel synthesis, characterisation, and photocatalytic activity of porous spinel Co3O4 nanosheets
Authors: Pudukudy Manoj , Yaakob Zahira 
Published: March 2014

AbstractMesoporous spinel Co3O4 nanosheets were synthesised via a simple sol-gel route using the Pluronic P123 triblock copolymer as the stabilising agent. Their structural, morphological, and textural properties were characterised. FTIR spectrum revealed the formation of cobalt oxide without any surface adsorbed impurities. Face centered cubic phase of spinel Co3O4 with the mean crystalline size of 26 nm was assigned by the X-ray diffraction analysis without the formation of other phases. Porous nanosheets and cave-like morphologies were identified from the scanning electron microscopy (SEM) images. Highly agglomerated more or less spherical particles with well separated lattice fringes, representing the oriented growth of nanocrystals, were noticed on the transmission electron microscopy photographs. Surface area analysis revealed that the spinel has high surface area of about 25 m2 g−1 with monomodal mesoporosity. The average pore size distribution was found to be about 15.8 nm. The as-prepared spinel photocatalyst showed a mild photocatalytic activity in the degradation of methylene blue (2.5 mg L−1) under UV light irradiation with air as the oxidising agent. Photocatalytic activity of the as-prepared reusable Co3O4 was found to be higher than that of the commercial spinel powder.
Laparoscopic vs. open inguinal hernia repair: A systematic review of literature
Authors: Gupta Amit , Jain SK , Kumar Sunil , Kaza RCM 
Published: March 2014

Inguinal hernia repair using mesh is one of the most frequently performed operations in general surgery. The mesh can be placed using an open technique or by laparoscopic approach. Many studies have highlighted the merits and risks of laparoscopic approach for the repair of inguinal hernia, the final sentence still remains to be written as majority of trials are too small to show clear benefits of one technique over another. To compare laparoscopic mesh repair with open method in management of inguinal hernia. Asian Journal of Medical Science, Volume-5(3) 2014: 11-14 DOI: http://dx.doi.org/10.3126/ajms.v5i3.9301
Isolation and Characterization of Plant Growth Promoting Rhizobacteria (PGPR) from Rice Rhizosphere of Varanasi and East Champaran District of India
Authors: Shrivastava Umesh Prasad 
Published: March 2014

Keeping with objective to search efficient PGPR isolates, 46 bacterial isolates were isolated from the rhizosphere of 17 rice fields of two districts of India employing standard enrichment techniques using JNFb- solid agar medium. Among all isolates, ECI-10A showed highest nitrogenase activity (1.72 ± 0.09 mmol C2H4 formed/mg protein/h) and ECI-2A showed lowest activity (0.62 ± 0.08 mmol C2H4 formed/mg protein/h). IAA production, P-solubilization and siderophore production were also tested among these isolates. Highest IAA production, P-solubilization and siderophore production were recorded in AF-7C (7.36 ± 0.38 µg/mg dry weight), ECI-12A (188.65 ± 8.65 µg/mg dry weight) and ECI-10B (20.43 ± 3.94 μg/ mg dry weight) respectively; whereas, lowest in AF-4B (2.3 ± 0.3 µg/mg dry weight), AF-1C (12.47 ± 3.5µg/mg dry weight) and AF-4B (1.45 ± 2.32 μg/ mg dry weight) respectively. Pseudomonas, Klebsiella, Azotobacter and Agrobacterium were predominantly present in the rhizosphere of rice plants of both districts of India is reported in present investigation.Academic Voices, Vol. 3, No. 1, 2013, Pages 81-90 DOI: http://dx.doi.org/10.3126/av.v3i1.9542
Maithili in Medieval Nepal : A Historical Apprisal
Authors: Das Basudevlal 
Published: March 2014

Nepal is a multi-linguistic nation. Maithili is one of the major languages of Nepal. This is spoken as a mother-tongue in eastern Tarai of Nepal. Historically speaking, the development of Maithili language took place in medieval period, where the two dynasties i.e. the Karnatas of Mithila and the Senas of Makawanpur had played major roles. Maithili expanded towards Kathmandu valley also. There are many manuscripts written in Maithili preserved in National Archive, Kathmandu. Even now, in the devotional songs sang by the aged persons in Kathmandu valley, there are many Maithili words found. Describing the importance of Maithili language in medieval period, this article may be a historical background for the people engaged in policy making and the language movement. Academic Voices, Vol. 3, No. 1, 2013, Pages 1-3 DOI: http://dx.doi.org/10.3126/av.v3i1.9704