bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of intracranial approaches for craniopharyngiomas: an analysis of the first 160 historical procedures
Authors: Pascual José María , Prieto Ruth , Castro-Dufourny Inés , Carrasco Rodrigo , Strauss Sewan , Barrios Laura 
Published: April 2014

Object
The development of surgical procedures for the removal of craniopharyngiomas (CPs) was greatly influenced by the enormous topographical and morphological heterogeneity displayed by these lesions. In this study the authors reviewed the intracranial approaches designed to treat CPs during the early historical period (1891–1938) with the aim of finding the CP topographical and pathological features that influence patient outcomes.

Methods
The authors conducted a systematic retrospective review of well-described cases of surgically treated CPs in publications from the period 1891–1938. Valuable information regarding the diagnosis of the lesion, type of craniotomy performed, CP topography, and outcome was selected from 418 reports included in medical publications from this period. The type of surgical procedure used, degree of tumor removal, CP position and histological variety, and clinical evidence of postoperative hypothalamic injury were the variables analyzed with the aim of defining their influence on the final patient outcome.

Results
A collection of 160 cases was eligible for analysis. Craniopharyngioma topography was significantly related to the existence of postoperative hypothalamic damage and the degree of tumor removal achieved (p < 0.001). The infundibulo-tuberal, or not strictly intraventricular, topography was associated with the highest rate of hypothalamic injury (84%) and impossibility of tumor removal (51%). This topography also showed the worst prognosis (p = 0.001). Additional variables correlated with patient outcome were the presence of hypothalamic damage, type of surgical approach used, and degree of tumor removal. Patients having a poor outcome, suffering from permanent coma, or dying after surgery presented with symptoms of hypothalamic injury in 40% of cases (p < 0.001). The surgical approach associated with the best outcome was the transsphenoidal (58%), followed by the subfrontal (45%) and the transcallosal (45%). Subtotal resection of the lesion yielded the best postoperative results, with only 17% of patients dying or suffering from a poor outcome, in contrast to the 39% reported for gross-total removal of the lesion (p = 0.001).

Conclusions
Two major variables influenced the results of early surgical experience with CPs for the period from 1891 to 1938: 1) the inaccuracy in defining CP topography with the diagnostic methods available at that time; and 2) the ignorance about the risks associated with the dissection of lesions showing tenacious adherence to the hypothalamus. The degree of functional and morphological disturbance of the hypothalamus caused by a CP remains a fundamental variable helping the surgeon to predict the risks associated with the radical excision of the tumor and patient outcome.
LONGITUDINAL STUDY ON LIVER FUNCTIONS IN PATIENTS WITH THALASSEMIA MAJOR BEFORE AND AFTER DEFERASIROX (DFX) THERAPY
Authors: Soliman Ashraf Tawfik , Yassin Mohamed , AlYafei Fawzia , Al-Naimi Lolwa , Almarri Noora , Sabt Aml , De Sanctis Vincenzo 
Published: April 2014

With regular blood transfusion and iron chelation therapy, most patients with thalassemia major (BTM) now survive beyond the third decade of life . Liver disease is becoming an important cause of morbidity and mortality in these patients. Chronic hepatitis and/or severe iron overload are important causes of liver pathology. Iron chelation with desferrioxamine (Desferal) reduces excessive body iron, but its efficacy is limited by poor compliance and dose related toxicity. The recent use of Deferasirox (Exjade- DFX ), an oral single dose therapy has improved the compliance to chelation therapy.Aims: To study the long-term liver functions in BMT patients, seronegative for liver infections before versus after DFX therapy in relation to ferritin level and IGF-I level.Methods: Liver function tests including: serum bilirubin, alanine transferase (ALT), aspartate transferase (AST) , albumin, insulin-like growth factor – I (IGF-I) and serum ferritin concentrations were followed every 6 months in 40 patients with BTM, with hepatitis negative screening (checked every year), for at least five years of DFO therapy and 4-5 years of DFX therapy .Results: DFX therapy (20 mg/kg/day) significantly decreased serum ferritin level in patients with BTM, this was associated with significant decrease in serum ALT, AST, ALP and increase in IGF-I concentrations. Albumin concentrations did not change after DFX treatment. ALT and AST levels were correlated significantly with serum ferritin concentrations ( r = 0.45 and 0.33 respectively , p < 0.05) . IGF-I concentrations were correlated significantly with serum ALT (r= 0.26, p = 0.05) but not with AST, ALP, bilirubin or albumin levels.The negative correlation between serum ferritin concentrations and ALT suggests that impairment of hepatic function negatively affects IGF-I synthesis in these patients due to iron toxicity, even in the absence of hepatitis.Conclusions: Some impairment of liver function can occur in hepatitis negative BMT patients with iron overload. The use of DFX was associated with mild but significant reduction of ALT, AST and ALP and increase in IGF-I levels. The negative correlation between IGF-I and ALT concentrations suggest that preventing hepatic dysfunction may improve the growth potential in these patients.
TYROSINE KINASE INHIBITORS AND PREGNANCY
Authors: Abruzzese Elisabetta , Trawinska Malgorzata Monika , De Fabritiis Paolo , Perrotti Alessio Pio 
Published: April 2014

The management of patients with chronic myeloid leukemia (CML) during pregnancy has became recently a matter of continuous debate. The introduction of the Tyrosine Kinase Inhibitors (TKIs) in clinical practice has dramatically changed the prognosis of CML patients. Patients diagnosed in chronic phase can reasonably expect many years of excellent disease control and good quality of life, as well as a normal life expectancy. This fact has come the necessity to address issues relating to fertility and pregnancy. Physicians are not infrequently being asked for advice regarding the need for, and or the appropriateness of, stopping treatment in order to conceive. In this report we will review the data published in terms of fertility, conception, pregnancy, pregnancy outcome and illness control for all the approved TKIs, as well as suggest how to manage a planned and/or unplanned pregnancy.
Eritrea’s Damages Claims (Eritrea v. Ethiopia), Final Award. Ethiopia’s Damages Claims (Ethiopia v. Eritrea), Final Award
Authors: Weeramantry J. Romesh 
Published: April 2014

ERITREA'S DAMAGES CLAIMS (ERITREA V. ETHIOPIA), FINAL AWARD.Athttp://www.pca-cpa.org.Eritrea Ethiopia Claims Commission, August 17, 2009.ETHIOPIA'S DAMAGES CLAIMS (ETHIOPIA V. ERITREA), FINAL AWARD.Athttp://www.pca-cpa.org.Eritrea Ethiopia Claims Commission, August 17, 2009.
Détournements savants du jazz en France et en Allemagne (1919-1922) : Adieu New-York ! de Georges Auric et le « Ragtime » de la Suite 1922 de Paul Hindemith
Authors: Guerpin Martin 
Published: April 2014

La plupart des travaux consacrés à l’influence du jazz dans le domaine de la musique savante s’attachent à relever les points communs et les différences de certaines oeuvres avec le modèle musical auquel elles empruntent.À partir de deux oeuvres représentatives de ces emprunts au début des années 1920,Adieu New-York !de Georges Auric (1919) et le « Ragtime » de laSuite 1922de Paul Hindemith, cet article propose d’élargir la perspective comparatiste à des problématiques relevant du domaine des transferts culturels, afin de dégager la dimensionnationalede la réception et de l’utilisation du jazz dans la musique savante au début des années 1920, en France et en Allemagne.De quels répertoires de jazz Auric et Hindemith ont-ils pu avoir connaissance ? Comment caractériser la manière particulière dont leurs oeuvres empruntent à ces répertoires ? En quoi des spécificités nationales jouent-elles un rôle dans la manière dont les compositeurs savants utilisent le jazz dans leurs oeuvres ?Loin de chercher à reproduire fidèlement ces musiques,Adieu New-York !et le « Ragtime » de laSuite 1922détournent les caractéristiques musicales du jazz afin de proposer de nouvelles voies à la musique savante, hors des canons esthétiques issus du romantisme. Le jazz apparaît ainsi comme un moyen pour de jeunes compositeurs d’affirmer leur singularité. Dans le même temps, chacune de ces oeuvres emprunte paradoxalement à une musique alors clairement identifiée comme étrangère pour affirmer sa propre identité musicale nationale. Alors qu’Adieu New-York !peut être considéré comme la mise en oeuvre de la redéfinition de l’identité musicale française proposée par Jean Cocteau dansLeCoq et l’Arlequin, le « Ragtime » de Paul Hindemith et sonesthétique du laids’inscrivent en droite ligne dans un courant expressionniste alors en vogue dans la jeune République de Weimar.
Conjecture, conjoncture, ouverture : une vue non déterministe de la traduction (Popper, Kuhn et Feyerabend « revisités »)
Authors: Lamy Laurent 
Published: April 2014

Le présent article situe l’expérience de la traduction et la réflexion traductologique dans le cadre des débats épistémologiques initiés avec les travaux de Popper, Kuhn et Feyerabend. Pour ce faire, nous examinons un échantillonnage de propositions relatives à l’épistémè poppérienne et darwinienne mise de l’avant par Andrew Chesterman, l’incommensurabilité entre les programmes de recherche de Berman et de Toury, l’introduction aux études basées sur le corpus par Mona Baker, en référence à la notion de « troisième code » introduite par William Frawley, et, enfin, le caractère évolutif du protocole élaboré par l’équipe du GRETI pour sa retraduction de Faulkner. Nous sommes ainsi parvenus à trois constats : 1) tout traitement des données dans le cadre de la réflexion traductologique repose sur un savoir a posteriori et doit n’admettre qu’une axiomatisation « faible » liée à l’observation de tendances et de régularités n’obéissant pas nécessairement à une causalité ou à une finalité stricte ; 2) toute proposition élaborée dans ce cadre doit conserver un caractère non déterministe ; 3) la traduction comme expérience et la réflexion qui s’en inspire obéissent à un protocole évolutif. Nous concluons en exposant quelques prémisses d’une épistémologie pluraliste, ouverte, en nous inspirant de l’attitude critique défendue par l’épistémologue autrichien Paul Feyerabend.
Le « prendre soin » de la santé (PSS) : une conception transdisciplinaire et inclusive de la pratique soignante et son intérêt pour améliorer les résultats de santé des jeunes aux prises avec le diabète
Authors: Charron Danielle , Tranchant Carole C. , Briand Emily , Aquino-Russell Catherine 
Published: April 2014

La prévalence accrue des maladies chroniques, dont celles pour lesquelles la prévention est possible, met en relief certaines limites des perspectives de soins de santé couramment déployées. Nous soutenons qu’une meilleure compréhension du « prendre soin », qui ne se limite pas aux actes médicaux et infirmiers, ni à la science infirmière, est nécessaire pour améliorer les pratiques et les résultats de santé. Prendre soin de la santé (PSS), comprenant le « prendre soin de soi », est un concept plus large que l’observance du traitement et l’autogestion de la maladie ou de la santé. Cet article vise à explorer l’intérêt du PSS. Une recherche documentaire a été réalisée pour mieux cerner les particularités du PSS, en examinant les fondements philosophiques, théoriques et pratiques du « prendre soin » par rapport à d’autres approches, dont lecaring, et aux défis rencontrés. La problématique de santé des jeunes diabétiques et de leur famille sert d’ancrage à la réflexion proposée. Pour cette problématique, entre autres, la recension des écrits suggère que le PSS est porteur de possibilités pour améliorer l’accompagnement et la qualité de vie des personnes atteintes et pour développer l’agir préventif.
Entre santé publique et organisation communautaire : points de convergence et de divergence autour du développement des communautés au Québec
Authors: Parent André-Anne , O’Neill Michel , Roy Bernard , Simard Paule 
Published: April 2014

Le développement des communautés a pris un essor important au Québec depuis qu’il a été inscrit comme stratégie transversale dans le Programme national de santé publique en 2003. Reconnue comme une stratégie de promotion de la santé et soutenue par l’action communautaire, la mise en place d’une démarche de développement des communautés suppose toutefois un changement de paradigme de la part de divers acteurs professionnels. En effet, agir dans ce domaine amène deux champs d’intervention à se modifier : la santé publique et l’organisation communautaire. Dans ce texte, nous retraçons l’histoire de ces champs depuis les années 1970 et nous montrons de quelle façon le développement des communautés les incitent aujourd’hui à travailler ensemble. Nous dégageons également les principaux points de convergence et de divergence qui sous-tendent les pratiques liées au développement des communautés de ces deux champs professionnels.
The spatiotemporal distribution of dissolved inorganic and organic carbon in the main stem of the Changjiang (Yangtze) River and the effect of the Three Gorges Reservoir
Authors: Zhang Longjun , Xue Ming , Wang Min , Cai Wei‐Jun , Wang Liang , Yu Zhigang 
Published: April 2014

AbstractThe Changjiang River supplies huge amounts of fresh water and dissolved and particulate substances to the East China Sea, thereby exerting a great influence on the coastal ecosystem. Meanwhile, the construction of the Three Gorges Reservoir (TGR) has reallocated the annual discharge, likely affecting the transportation of carbon in its various forms. The transport and transformation of carbon in Changjiang River and the effect of the TGR were discussed based on three field campaigns, a 1 year time series investigation, and historical data. Our results indicated the following: (1) Dissolved inorganic carbon (DIC) was derived from the upper stream and was significantly diluted downstream by the low‐DIC waters from two large lakes. Dissolved organic carbon (DOC) was a product of anthropogenic input and showed no clear relationship with discharge. particulate organic carbon (POC) within total suspended matter (POC%) was below the global average. (2) The TGR has not measurably affected the transport of DOC downstream of the reservoir dam. However, downstream grain size has decreased and autochthonous processes have increased, resulting in a sharp increase in POC% since reservoir construction. (3) For the period 1997–2010, estimated annual DIC flux was 16.9 Tg yr−1. The regulation of river flow by the TGR has decreased the river DIC flux to the East China Sea in the autumn and increased it in the spring. Furthermore, the South‐North Water Diversion will reduce the high‐DIC water from the upper reach, thus affecting the biogeochemistry of the Changjiang estuary and the ecosystem of the nearby coastal ocean.
An analysis of the quiet time day‐to‐day variability in the formation of postsunset equatorial plasma bubbles in the Southeast Asian region
Authors: Carter B. A. , Yizengaw E. , Retterer J. M. , Francis M. , Terkildsen M. , Marshall R. , Norman R. , Zhang K. 
Published: April 2014

AbstractPresented is an analysis of the occurrence of postsunset Equatorial Plasma Bubbles (EPBs) detected using a Global Positioning System (GPS) receiver at Vanimo. The three year data set shows that the EPB occurrence maximizes (minimizes) during the equinoxes (solstices), in good agreement with previous findings. The Vanimo ionosonde station is used with the GPS receiver in an analysis of the day‐to‐day EPB occurrence variability during the 2000 equinox period. A superposed epoch analysis (SEA) reveals that the altitude, and the change in altitude, of the F layer height is ∼1 standard deviation (1σ) larger on the days for which EPBs were detected, compared to non‐EPB days. These results are then compared to results from the Thermosphere Ionosphere Electrodynamics General Circulation Model (TIEGCM), which show strong similarities with the observations. The TIEGCM is used to calculate the flux‐tube integrated Rayleigh‐Taylor (R‐T) instability linear growth rate. A SEA reveals that the modeled R‐T growth rate is 1σ higher on average for EPB days compared to non‐EPB days, and that the upward plasma drift is the most dominant contributor. It is further demonstrated that the TIEGCM's success in describing the observed daily EPB variability during the scintillation season resides in the variations caused by geomagnetic activity (as parameterized by Kp) rather than solar EUV flux (as parameterized by F10.7). Geomagnetic activity varies the modeled high‐latitude plasma convection and the associated Joule heating that affects the low‐latitude F region dynamo, and consequently the equatorial upward plasma drift.
Net ecosystem methane and carbon dioxide exchanges in a Lake Erie coastal marsh and a nearby cropland
Authors: Chu Housen , Chen Jiquan , Gottgens Johan F. , Ouyang Zutao , John Ranjeet , Czajkowski Kevin , Becker Richard 
Published: April 2014

AbstractNet ecosystem carbon dioxide (FCO2) and methane (FCH4) exchanges were measured by using the eddy covariance method to quantify the atmospheric carbon budget at a Typha‐ and Nymphaea‐dominated freshwater marsh (March 2011 to March 2013) and a soybean cropland (May 2011 to May 2012) in northwestern Ohio, USA. Two year average annual FCH4 (49.7 g C‐CH4 m−2 yr−1) from the marsh was high and compatible with its net annual CO2 uptake (FCO2: −21.0 g C‐CO2 m−2 yr−1). In contrast, FCH4 was small (2.3 g C‐CH4 m−2 yr−1) and accounted for a minor portion of the atmospheric carbon budget (FCO2: −151.8 g C‐CO2 m−2 yr−1) at the cropland. At the seasonal scale, soil temperature associated with methane (CH4) production provided the dominant regulator of FCH4 at the marsh (R2 = 0.86). At the diurnal scale, plant‐modulated gas flow was the major pathway for CH4 outgassing in the growing season at the marsh. Diffusion and ebullition became the major pathways in the nongrowing season and were regulated by friction velocity. Our findings highlight the importance of freshwater marshes for their efficiency in turning over and releasing newly fixed carbon as CH4. Despite marshes accounting for only ~4% of area in the agriculture‐dominated landscape, their high FCH4 should be carefully addressed in the regional carbon budget.
Technical note: Introduction to MIMICA, a large‐eddy simulation solver for cloudy planetary boundary layers
Authors: Savre J. , Ekman A. M. L. , Svensson G. 
Published: April 2014

AbstractIn large‐eddy simulation (LES), large‐scale turbulent structures are explicitly resolved on the numerical grid while the dissipative turbulent eddies, typically smaller than the grid size, must be modeled. Because in the atmospheric boundary layer a large disparity of turbulent scales exists (about 9 orders of magnitude separate the largest and smallest scales), LES is considered as an essential modeling approach to capture the physics and dynamics of boundary layer clouds. A new LES solver developed at Stockholm University is presented here for the first time. The model solves for nonhydrostatic anelastic equations using high‐order low‐dissipative numerical schemes for the advection of scalars and momentum. A two‐moment bulk microphysics scheme is implemented representing five types of hydrometeors including ice crystals and snow. The LES is evaluated based on simulations of two well‐documented stratiform cloud events that were previously used for LES intercomparisons. In the first one, a marine drizzling stratocumulus observed during DYCOMS‐II, the model is shown to predict bulk cloud microphysical and dynamical properties within the range of the intercomparison model results. In the second case, based on a monolayer Arctic mixed‐phase cloud observed during ISDAC, we found that when using fast‐falling crystals, ice quickly precipitates out of the cloud without significant growth, resulting in very low ice water paths. The simulated clouds are also found to be very sensitive to the prescribed ice crystal number concentration: multiplying the ice concentration by a factor 2.5 results in rapid cloud dissipation in the most extreme case. Overall, these results are found to be consistent with former studies of Arctic mixed‐phase clouds as well as in situ measurements. More specifically, when the ice number concentration and parameterized ice habit are constrained by measurements, simulated microphysical properties such as the ice water path and ice crystal size distribution are found to agree well with observations.
Milk Consumption and Progression of Medial Tibiofemoral Knee Osteoarthritis: Data From the Osteoarthritis Initiative
Authors: Lu Bing , Driban Jeffrey B. , Duryea Jeffrey , McAlindon Timothy , Lapane Kate L. , Eaton Charles B. 
Published: April 2014

ObjectiveMilk consumption has long been recognized for its important role in bone health, but its role in the progression of knee osteoarthritis (OA) is unclear. We examined the prospective association of milk consumption with radiographic progression of knee OA.MethodsIn the Osteoarthritis Initiative, 2,148 participants (3,064 knees) with radiographic knee OA and dietary data at baseline were followed up to 12, 24, 36, and 48 months. Milk consumption was assessed with a Block Brief Food Frequency Questionnaire completed at baseline. To evaluate progression of OA, we used quantitative joint space width (JSW) between the medial femur and tibia of the knee based on plain radiographs. The multivariate linear models for repeated measures were used to test the independent association between milk intake and the decrease in JSW over time, while adjusting for baseline disease severity, body mass index, dietary factors, and other potential confounders.ResultsWe observed a significant dose‐response relationship between baseline milk intake and adjusted mean decrease of JSW in women (P = 0.014 for trend). With increasing levels of milk intake (none, ≤3, 4–6, and ≥7 glasses/week), the mean decreases of JSW were 0.38 mm, 0.29 mm, 0.29 mm, and 0.26 mm, respectively. In men, we observed no significant association between milk consumption and the decreases of JSW.ConclusionOur results suggest that frequent milk consumption may be associated with reduced OA progression in women. Replication of these novel findings in other prospective studies demonstrating the increase in milk consumption leads to delay in knee OA progression are needed.
Equilibration of the [2+2] Cycloaddition of Silyl Enol Ethers Catalyzed by Ethylaluminium Dichloride: Diastereoselectivity Switch in the Synthesis of Fused Cyclobutanes
Authors: Hata Kenji , Arichi Norihito , Yamaoka Yousuke , Yamada Ken‐ichi , Takemoto Yoshiji , Takasu Kiyosei 
Published: April 2014

AbstractThe process by which the reaction between silyl enol ethers and acrylates reached equilibrium through an EtAlCl2‐catalyzed [2+2] cycloaddition was characterized. The mechanism and substrate scope of the retro [2+2] cycloaddition were investigated. The trans or cis isomers can be selectively obtained by controlling the reaction temperature, although the substrate scope was found to be limited.