bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deciphering contaminants and toxins in fermented food for enhanced human health safeguarding
Authors: Pop Oana Lelia , Ciont (Nagy) Călina , Gabbianelli Rosita , Coldea Teodora Emilia , Pop Carmen Rodica , Mudura Elena , Min Thae , Rangnoi Kuntalee , Yamabhai Montarop , Vlaic Romina , Mureșan Crina , Suharoschi Ramona 
Published: August 2024

AbstractFermented foods have been a component of the human diet since ancient times, including live bacteria employed to restore gut health, contributing to the frontline of functional food progression. Human concern about the harmful consequences of possible contaminants has increased significantly as their toxicity, carcinogenicity, and teratogenicity have become more publicized. In order to take preventive measures, it is essential to correctly identify and define the implications of contaminants and toxins in human health and intestinal microbiota balance for preventing or diagnosing epidemics before they cause damage. The longer food chain that results from urbanization and underreporting of diseases makes it harder to correlate contaminated food to disease, which in turn presents challenges to improving food safety. This research aims to present the potential physical, chemical, and microbiological pollutants and toxins found in fermented products and their effects on human health. The scope tackles various categories of fermented foods, such as dairy products, alcoholic and nonalcoholic beverages, fermented meat products, traditional bakery products, and fermented cereals and vegetables. Furthermore, it examines specific control processes such as rigorous sanitation protocols, advanced packaging technologies, regulatory harmonization, and decontamination methodologies used to prevent the release of contaminants from fermented foods. Future viewpoints and opportunities are briefly mentioned in the conclusion.
Gut microbiota: A key role for human milk oligosaccharides in regulating host health early in life
Authors: Chen Qingxue , Ma Xinming , Guo Zhengtao , Zhang Peng , Li Bailiang , Wang Zhongjiang 
Published: August 2024

AbstractHuman milk oligosaccharides (HMOs) are an evolutionarily significant advantage bestowed by mothers for facilitating the development of the infant's gut microbiota. They can avoid absorption in the stomach and small intestine, reaching the colon successfully, where they engage in close interactions with gut microbes. This process also enables HMOs to exert additional prebiotic effects, including regulating the mucus layer, promoting physical growth and brain development, as well as preventing and mitigating conditions such as NEC, allergies, and diarrhea. Here, we comprehensively review the primary ways by which gut microbiota, including Bifidobacteria and other genera, utilize HMOs, and we classify them into five central pathways. Furthermore, we emphasize the metabolic benefits of bacteria consuming HMOs, particularly the recently identified intrinsic link between HMOs and the metabolic conversion of tryptophan to indole and its derivatives. We also examine the extensive probiotic roles of HMOs and their recent research advancements, specifically concentrating on the unsummarized role of HMOs in regulating the mucus layer, where their interaction with the gut microbiota becomes crucial. Additionally, we delve into the principal tools used for functional mining of new HMOs. In conclusion, our study presents a thorough analysis of the interaction mechanism between HMOs and gut microbiota, emphasizing the cooperative utilization of HMOs by gut microbiota, and provides an overview of the subsequent probiotic effects of this interaction. This review provides new insights into the interaction of HMOs with the gut microbiota, which will inform the mechanisms by which HMOs function.
Single‐cell transcriptomic atlas of taste papilla aging
Authors: Ren Wenwen , Li Weihao , Cha Xudong , Wang Shenglei , Cai Boyu , Wang Tianyu , Li Fengzhen , Li Tengfei , Xie Yingqi , Xu Zengyi , Wang Zhe , Liu Huanhai , Yu Yiqun 
Published: August 2024

AbstractTaste perception is one of the important senses in mammals. Taste dysfunction causes significant inconvenience in daily life, leading to subhealth and even life‐threatening condition. Aging is a major cause to taste dysfunction, while the underlying feature related to gustatory aging is still not known. Using single‐cell RNA Sequencing, differentially expressed genes between aged and young taste papillae are identified, including upregulated mt‐Nd4l and Xist, as well as downregulated Hsp90ab1 and Tmem59. In the Tmem59−/− circumvallate papillae (CVP), taste mature cell generation is impaired by reduction in the numbers of PLCβ2+ and Car4+ cells, as well as decreases in expression levels of taste transduction genes. Tmem59−/− mice showed deficits in sensitivities to tastants. Through screening by GenAge and DisGeNET databases, aging‐dependent genes and oral disease‐associated genes are identified in taste papillae. In the CVP, aging promotes intercellular communication reciprocally between (cycling) basal cell and mature taste cell by upregulated Crlf1/Lifr and Adam15/Itga5 signaling. By transcriptional network analysis, ribosome proteins, Anxa1, Prdx5, and Hmgb1/2 are identified as transcriptional hubs in the aged taste papillae. Chronological aging‐associated transcriptional changes throughout taste cell maturation are revealed. Aged taste papillae contain more Muc5b+ cells that are not localized in gustatory gland. Collectively, this study shows molecular and cellular features associated with taste papilla aging.
Developing a machine learning‐based instrument for subjective well‐being assessment on Weibo and its psychological significance: An evaluative and interpretive research
Authors: Han Nuo , Wen Yeye , Wang Bowen , Huang Feng , Liu Xiaoqian , Li Linyan , Zhu Tingshao 
Published: August 2024

AbstractDemystifying machine learning (ML) approaches through the synergy of psychology and artificial intelligence can achieve a balance between predictive and explanatory power in model development while enhancing rigor in validation and reporting standards. Accordingly, this study aimed to bridge this research gap by developing a subjective well‐being (SWB) prediction model on Weibo, serving as a psychological assessment instrument and explaining the model construction based on psychological knowledge. The model establishment involved the collection of SWB scores and posts from 1,427 valid Weibo users. Multiple machine learning algorithms were employed to train the model and fine‐tune its parameters. The optimal model was selected by comparing its criterion validity and split‐half reliability performance. Furthermore, SHAP values were calculated to rank the importance of features, which were then used for model interpretation. The criterion validity for the three dimensions of SWB ranged from 0.50 to 0.52 (P < 0.001), and the split‐half reliability ranged from 0.94 to 0.96 (P < 0.001). The identified relevant features were related to four main aspects: cultural values, emotions, morality, and time and space. This study expands the application scope of SWB‐related psychological theories from a data‐driven perspective and provides a theoretical reference for further well‐being prediction.
Resilience in multicultural classrooms: School relationships can protect the school adjustment of immigrant, refugee and non‐immigrant children
Authors: Ialuna Francesca , Civitillo Sauro , McElvany Nele , Leyendecker Birgit , Jugert Philipp 
Published: August 2024

AbstractBackgroundAccording to the risk and resilience perspective, protective factors can attenuate the effect of risks and challenges on children's adjustment. For immigrant and refugee children, supportive relationships in the new context can be particularly beneficial. We expected that supportive school relationships play a protective role for the school adjustment of first‐generation immigrant and refugee and non‐immigrant children, by moderating the effect of one acculturative challenge (i.e., school language proficiency).AimsWe investigated the moderating roles of teacher–child and peer relationship quality on the association between German language proficiency and school adjustment (i.e., school achievement and belongingness) among first‐generation immigrant and refugee and non‐immigrant children.SampleWe recruited n = 278 fourth grade children (Mage = 10.47, SDage = .55, 53.24% female; 37% first‐generation immigrant and refugee children).MethodsQuestionnaires assessed children's reported teacher–child and peer relationship quality and school belongingness. One vocabulary test measured children's German proficiency. School achievement was assessed by their grade point average (GPA) and by a reading comprehension test. To investigate our hypotheses, we performed path analyses.ResultsTeacher–child relationship mitigated the effect of German proficiency on children's reading comprehension among all children and on GPA among immigrant and refugee children only. Peer relationship buffered the negative effect of German proficiency on school belongingness.ConclusionsTeacher–child and peer relationship quality can be beneficial for the school adjustment of both first‐generation immigrant and refugee children and non‐immigrant children.
Connecting the tots: Strong looking‐pointing correlations in preschoolers' word learning and implications for continuity in language development
Authors: Creel Sarah C. 
Published: August 2024

AbstractHow does one assess developmental change when the measures themselves change with development? Most developmental studies of word learning use either looking (infants) or pointing (preschoolers and older). With little empirical evidence of the relationship between the two measures, developmental change is difficult to assess. This paper analyzes 914 pointing, looking children (451 female, varied ethnicities, 2.5–6.5 years, dates: 2009–2019) in 36 word‐ or sound‐learning experiments with two‐alternative test trials. Looking proportions and pointing accuracy correlated strongly (r = .7). Counter to the “looks first” hypothesis, looks were not sensitive to incipient knowledge that pointing missed: when pointing is at chance, looking proportions are also. Results suggest one possible path forward for assessing continuous developmental change. Methodological best practices are discussed.
Clinical characteristics, longitudinal adaptive functioning, and association with electroencephalogram activity in PPP2R5D‐related neurodevelopmental disorder
Authors: Sudnawa Khemika K. , Pini Nicolò , Li Wenxing , Kanner Cara H. , Ryu Joseph , Calamia Sean , Bain Jennifer M. , Goldman Sylvie , Montes Jacqueline , Shen Yufeng , Chung Wendy K. 
Published: August 2024

AbstractProtein phosphatase 2 regulatory subunit B56δ related neurodevelopmental disorder (PPP2R5D‐related NDD) is largely caused by de novo heterozygous missense PPP2R5D variants. We report medical characteristics, longitudinal adaptive functioning, and in‐person neurological, motor, cognitive, and electroencephalogram (EEG) activity for PPP2R5D‐related NDD. Forty‐two individuals (median age 6 years, range = 0.8–25.3) with pathogenic/likely pathogenic PPP2R5D variants were assessed, and almost all variants were missense (97.6%) and de novo (85.7%). Common clinical symptoms were developmental delay, hypotonia, macrocephaly, seizures, autism, behavioral challenges, and sleep problems. The mean Gross motor functional measure‐66 was 60.2 ± 17.3% and the mean Revised upper limb module score was 25.9 ± 8.8. The Vineland‐3 adaptive behavior composite score (VABS‐3 ABC) at baseline was low (M = 61.7 ± 16.8). VABS‐3 growth scale value scores increased from baseline in all subdomains (range = 0.6–5.9) after a mean follow‐up of 1.3 ± 0.3 years. EEG beta and gamma power were negatively correlated with VABS‐3 score; p < 0.05. Individuals had a mean Quality‐of‐life inventory‐disability score of 74.7 ± 11.4. Twenty caregivers (80%) had a risk of burnout based on the Caregiver burden inventory. Overall, the most common clinical manifestations of PPP2R5D‐related NDD were impaired cognitive, adaptive function, and motor skills; and EEG activity was associated with adaptive functioning. This clinical characterization describes the natural history in preparation for clinical trials.
Entropy‐driven Progressive Compression of 3D Point Clouds
Authors: Zampieri A. , Delarue G. , Bakr N. Abou , Alliez P. 
Published: August 2024

Abstract3D point clouds stand as one of the prevalent representations for 3D data, offering the advantage of closely aligning with sensing technologies and providing an unbiased representation of a measured physical scene. Progressive compression is required for real‐world applications operating on networked infrastructures with restricted or variable bandwidth. We contribute a novel approach that leverages a recursive binary space partition, where the partitioning planes are not necessarily axis‐aligned and optimized via an entropy criterion. The planes are encoded via a novel adaptive quantization method combined with prediction. The input 3D point cloud is encoded as an interlaced stream of partitioning planes and number of points in the cells of the partition. Compared to previous work, the added value is an improved rate‐distortion performance, especially for very low bitrates. The latter are critical for interactive navigation of large 3D point clouds on heterogeneous networked infrastructures.
Higher solubility and lower onset temperature of protein denaturation increase the osteoconductive capacity of collagen membranes: A preclinical in vivo study
Authors: Sadat‐Marashi Zahra , Fujioka‐Kobayashi Masako , Katagiri Hiroki , Lang Niklaus P. , Saulacic Nikola 
Published: August 2024

AbstractObjectivesCollagen membranes are extensively used for guided bone regeneration procedures, primarily for horizontal bone augmentation. More recently, it has been demonstrated that collagen membranes promote bone regeneration. Present study aimed at assessing if structural modifications of collagen membranes may enhance their osteoconductive capacity.MethodsTwenty‐four adult Wistar rats were used. Bilateral calvaria defects with a diameter of 5 mm were prepared and covered with prototypes of collagen membranes (P1 or P2). The P1 membrane (positive control) presented a lower onset temperature of protein denaturation and a higher solubility than the P2 membrane (test). The contralateral defects were left uncovered (NC). After 1 and 4 weeks, the animals were euthanized. A microcomputed tomography analysis of the harvested samples was performed within and above the bony defect. Undecalcified ground sections were subjected to light microscopy and morphometric analysis.ResultsBone formation was observed starting from the circumferential borders of the defects in all groups at 1‐week of healing. The foci of ossification were observed at the periosteal and dura mater sites, with signs of collagen membrane mineralization. However, there was no statistically significant difference between the groups. At 4 weeks, remnants of the collagen fibers were embedded in the newly formed bone. In the P2 group, significantly more bone volume, more new bone, and marrow spaces compared to the NC group were observed. Furthermore, the P2 group showed more bone volume ectocranially then the P1 group.ConclusionsBone formation subjacent to a P2 membrane was superior than subjacent to the P1 membrane and significantly better compared to the control. Modifications of the physico‐chemical properties may enhance the osteoconductive competence of collagen membranes, supporting bone formation outside the bony defects.
A 7.5‐year randomized controlled clinical study comparing cemented and screw‐retained one‐piece zirconia‐based implant‐supported single crowns
Authors: Kraus Riccardo D. , Hjerppe Jenni , Naenni Nadja , Balmer Marc , Jung Ronald E. , Thoma Daniel S. 
Published: August 2024

AbstractObjectivesTo compare marginal bone levels, biological, and technical outcomes of screw‐retained versus cemented all‐ceramic implant‐supported zirconia‐based single crowns after an observation period of 7.5 years.MethodsForty‐four single implants in the esthetic zone in 44 patients (22 females, 22 males) were randomly assigned to two types of restorations: SR (screw‐retained); veneered one‐piece zirconia abutment and CR (cement‐retained); veneered lithium disilicate crown intraorally cemented on a one‐piece zirconia abutment. Patients were recalled annually up to 7.5 years and survival rates, biological, and technical parameters assessed.ResultsA total of 31 patients attended the 7.5‐year follow‐up visit (17 SR group, 14 CR group). The survival rate on the restorative level was 77.5% (74.0% CR, 81.0% SR, p = .6399). Median marginal bone loss (MBL) values yielded −0.073 mm (−0.305; 0.238) in the CR and −0.215 mm (−0.500; 0.555) in the SR group (intergroup p = .6194). Mean bleeding on probing (BoP) values were significantly in favor of group SR with 20 ± 17% compared to 40 ± 22% in group CR (p = .011). The overall biological complication rate amounted to 27.5% (42.1% CR, 14.3% SR, p = .0775), whereas the technical complication rate was 32.5% (42.1% CR, 23.8% SR, p = .314). In total, CR restorations showed significantly more complications (84.2% for CR, 38.1% for SR, p = .0041).ConclusionOne‐piece zirconia‐based single crowns on two‐piece dental implants exhibited a high rate of technical and biological complications at 7.5 years of follow‐up. Cemented restorations revealed significant higher rates of bleeding on probing and total complications compared to screw‐retained restorations.
Theory of Mind Abilities May Predict Treatment Outcomes in Adolescents With Obsessive‐Compulsive Disorder: A Follow‐Up Study
Authors: Kara Tayfun , Aydoğan Avşar Pınar , Kuru Tacettin , Kocaman Orhan 
Published: August 2024

ABSTRACTAimsResearchers report varying levels of cognitive flexibility and theory of mind (ToM) deficiencies in adolescents with obsessive‐compulsive disorder (OCD). This research set out to investigate the impact of these variables on the disorder's outcomes.MethodThe study involved 39 adolescents with OCD and 40 healthy controls. We assessed the case group at the initial visit to the outpatient clinic and again at the end of the first year of treatment. The Children's Yale‐Brown Obsessive‐Compulsive Scale (CY‐BOCS) was applied to assess OCD symptom distribution and severity. The Reading the Mind in the Eyes of Children Test (RME‐CT) was applied to evaluate ToM skills, and the Cognitive Flexibility Scale (CFS) was employed to evaluate cognitive flexibility levels.ResultsBaseline RME‐CT and CFS scores were significantly lower in adolescents with OCD compared to the control group (p = 0.002 p = 0.001, respectively). At the end of the 1‐year follow‐up, RME‐CT and CFS scores increased significantly in the adolescents with OCD (p < 0.001, p = 0.003, respectively). A significant negative correlation was observed between the initial RME‐CT scores and the Y‐BOCS scores at the end of the 1‐year follow‐up (p < 0.001). The initial RME‐CT score had a significant negative predictive effect on the subsequent severity of OCD (β = −0.711, p < 0.001).ConclusionsThe research revealed poorer long‐term prognoses for OCD in adolescents who exhibit low ToM skills. In conclusion, the results indicate that ToM skills may serve as a predictive factor for long‐term treatment outcomes among adolescents diagnosed with OCD.
The cardiotoxic effects of CAR‐T cell therapy: An updated systematic review and meta‐analysis
Authors: Mazetto Roberto A. S. V. , Monteiro Sarah O. N. , Bulhões Elísio , Defante Maria L. R. , Antunes Vanio L. J. , Balieiro Caroline Cristine Almeida , Feitoza Luanna , Ferreira André L. C. , Carvalho Amadeu M. , Guida Camila 
Published: August 2024

AbstractBackgroundChimeric antigen receptor T‐cell (CAR‐T) therapy has shown promise in treating hematologic malignancies, yet its potential cardiotoxic effects require thorough investigation.ObjectivesWe aim to conduct a systematic review and meta‐analysis to examine the cardiotoxic effects of CAR‐T therapy in adults with hematologic malignancies.MethodsWe searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials for studies reporting cardiovascular outcomes, such as arrhythmias, heart failure, and reduced left ventricle ejection fraction (LVEF).ResultsOur analysis of 20 studies involving 4789 patients revealed a 19.68% incidence rate of cardiovascular events, with arrhythmias (7.70%), heart failure (5.73%), and reduced LVEF (3.86%) being the most prevalent. Troponin elevation was observed in 23.61% of patients, while NT‐Pro‐BNP elevation was observed in 9.4. Subgroup analysis showed higher risks in patients with pre‐existing conditions, such as atrial arrhythmia (OR 3.12; p < .001), hypertension (OR 1.85; p = .002), previous heart failure (OR 3.38; p = .003), and coronary artery disease (OR 2.80; p = .003).ConclusionVigilant cardiovascular monitoring is crucial for patients undergoing CAR‐T therapy to enhance safety and treatment efficacy.Novelty Statements.
Development and psychometric evaluation of a new domain‐specific coparenting measure: Coparenting Children's Emotion Scale
Authors: Ambrosi Christina C. , Kavanagh Phillip S. , Evans Subhadra , Havighurst Sophie S. 
Published: August 2024

AbstractCaregivers play an integral role in supporting children's development, not only through their individual parenting practices but also how they work together as coparents. The literature on coparenting is extensive; however, most of the research has relied on global measures to assess the quality and functioning of the coparenting relationship. Examining the coparenting relationship with domain‐specific measures enables a deeper understanding of this complex family process. One domain of particular interest is emotion socialization given the vast and long‐term consequences emotion socialization has on children's emotional, social, behavioral, and psychological functioning. Emotion socialization literature would benefit from a domain‐specific coparenting measure, as researchers have rarely explored how coparents work together when responding to their children's emotions (i.e., coparenting children's emotions). As such, an emotion‐focused coparenting measure could address gaps in both coparenting and emotion socialization literature. This study outlines the development and psychometric evaluation of a domain‐specific measure of coparenting, the Coparenting Children's Emotion Scale (CCES), which assesses how parents work together when responding to their children's emotions. In the current study, the factor structure, reliability, and validity of the CCES were examined in an Australian sample. Findings from exploratory and confirmatory factor analyses showed that the CCES comprises two subscales that capture coparents' levels of support/cooperation and undermining. In the current sample, both CCES subscales demonstrated good to excellent internal consistency, and good convergent and concurrent validity. The CCES will provide researchers and practitioners with a domain‐specific measure to use in exploratory and intervention research.