bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acquired factor VII deficiency associated with synovial sarcoma
Authors: Chindaprasirt Jarin , Wanitpongpun Chinadol , Ungareewittaya Piti 
Published: August 2015

Abstract
Background: Acquired factor VII (FVII) deficiency mostly results from liver disease or vitamin K antagonists. Isolated acquired FVII deficiency is a rare event, and only a few cases have been reported. To our knowledge, this is the first reported case of synovial sarcoma associated with FVII deficiency.
Objective: To describe our findings in a 20-year-old man, who presented with hemoptysis, weight loss, and later developed a suprascapular mass.
Methods: A review of the medical record of the patient plus a comparison with the literature was conducted.
Results: A biopsy from a suprascapular mass was made and the histopathological diagnosis of the tumor was confirmed as synovial sarcoma. Initial studies indicated a normal activated partial thromboplastin time and a prolonged prothrombin time. The FVII level was 31%. No evidence of a FVII inhibitor or inactivator was demonstrated. Prothrombin time normalized during tumor regression and FVII level was elevated to 103%.
Conclusion: Clinicians should be alert to the possible association of acquired FVII deficiency in cancer patients.
Damage control surgery in blunt cardiac injury
Authors: Prichayudh Supparerk , Kritayakirana Kritaya , Samorn Pasurachate , Pak-art Rattaplee , Sriussadaporn Sukanya , Sriussadaporn Suvit , Kiatpadungkul Wilaiporn , Thatsakorn Kanthachat , Viratanapanu Ithiphon 
Published: August 2015

Abstract
Background: Blunt cardiac injury (BCI) is a rare, but life threatening injury. The treatment of BCI is surgical repair. However, in a BCI patient with hypothermia, acidosis, and coagulopathy, an attempt to control the bleeding completely by surgery alone may not be successful. Damage control principles should be used in this situation.
Objective: To study a BCI patient who underwent a successful operation using damage control principles.
Methods: We reviewed and analyzed the patient’s chart, operative notes and follow up visit records. Review of the literature regarding the issue was also conducted.
Results: We report the case of a patient with BCI who developed hypothermia and coagulopathy during surgery. Abbreviated surgical repair was performed with a right pleuropericardial window created to avoid blood accumulation in the pericardial sac. Subsequent aggressive resuscitation was performed in the intensive care unit. We accepted ongoing bleeding through the right chest tubes while correction of hypothermia and coagulopathy was undertaken. The bleeding was gradually stopped once the patient’s physiology was restored. Although the patient developed a retained right hemothorax requiring subsequent video-assisted thoracoscopic surgery on the third postoperative week, he recovered uneventfully and was discharged on postoperative day 36.
Conclusion: In patients with BCI who develop coagulopathy during surgery, terminating the operation quickly and creating a pleuropericardial window is a possible bailout solution because this can prevent postoperative cardiac tamponade without leaving the chest open. Continue bleeding from the chest tubes is acceptable provided that adequate resuscitation to correct coagulopathy is underway.
Antimicrobial agents and Burkholderia pseudomallei: perspectives from Thailand
Authors: Panomket Pawana 
Published: August 2015

Abstract
Background: Burkholderia pseudomallei are the causative agent of melioidosis, a potentially life-threatening disease in humans and animals. It is a common public health threat in parts of Thailand.
Objective: To summarizes the current knowledge regarding antimicrobial agents and B. pseudomallei.
Methods: A literature search using MEDLINE (PubMed), SCOPUS, and OVID/LWWW databases.
Results: B. pseudomallei are intrinsically resistant to a wide range of antimicrobial agents including β-lactam antibiotics, aminoglycosides, and macrolides. Antimicrobial therapy for melioidosis is divided into an acute phase and an eradication phase. The current recommendations for the acute phase are parenteral antimicrobial agents for ≥10 days using ceftazidime or a carbapenem. The eradication phase involves oral antimicrobial agents for ≥180 days using trimethoprim-sulfamethoxazole. Amoxicillin-clavulanic acid may be used as an alternative. Ceftazidime revealed rare primary resistance and a high relapse rate.
Conclusion: Patients with acute melioidosis usually need intensive care and appropriate antibiotics for the acute and eradication phases. Ceftazidime is remains an effective agent in Thailand. A trend for decreasing susceptibility to antibiotics requires monitoring.
A novel approach to ultrasound-guided percutaneous native renal biopsy: a better tissue sampling technique
Authors: Chancharoenthana Wiwat , Kanjanabuch Talerngsak , Kittikowit Wipawee , Srisawat Nattachai , Tiranathanagula Khajohn , Praditpornsilpa Kearkiat , Tungsanga Kriang , Eiam-Ong Somchai 
Published: August 2015

AbstractBackground: Percutaneous renal biopsy (PRB) is an essential tool in diagnosis and management of various renal diseases. Conventional ultrasound-guided free-hand approaches to the lower pole of the kidney for PRB yield marginal tissue adequacy and causes a certain incidence of bleeding complications.Objective: To describe a novel ultrasound-guided approach to the middle part of the kidney for PRB to obtain better tissue sampling.Patients and methods: The plane angle between the renal biopsy needle and the skin was set at 30° for patients in the novel middle part approach group (n = 15) and 45° for patients in the conventional lower pole approach group (n = 15).Results: The perpendicular distance between the needle tip and renal capsule in the middle part approach was significantly shorter than the lower pole approach group (0.92 ± 0.6 vs. 1.49 ± 0.4 cm, p = 0.005). The middle part approach to PRB yielded a significantly higher number of glomeruli (22.8 ± 7.2 vs. 15.3 ± 4.1, p = 0.002) and arcuate arteries (0.9 ± 0.6 vs. 0.5 ± 0.1, p = 0.02). The bleeding complications in the middle part approach seemed to be less than in the lower pole approach technique. Pain scores between the two methods as assessed using a visual analog scale were not different.Conclusion: This novel approach to the middle part of the kidney for PRB provides comparable patient satisfaction and a superior adequacy of renal tissue when compared with the conventional lower pole approach with its consequent lower post biopsy bleeding complications. Larger studies to confirm this finding are warranted.
Mini review article. Human herpesvirus-6 and the etiology of multiple sclerosis: a literature review
Authors: Hon Gloudina M. , Erasmus Rajiv T. , Matsha Tandi E. 
Published: August 2015

Abstract
Background: There is no consensus in the literature on the role of human herpes virus-6 (HHV-6) in multiple sclerosis (MS) onset or progression.
Objective: We evaluated a possible role for HHV-6 in MS onset and progression.
Methods: We conducted a literature search of PubMed and Google scholar with the following search terms: (“multiple sclerosis” OR “MS”) and (“Human Herpes Virus-6” OR “HHV-6”).
Results: A total 21 publications were retrieved, of which 19 case-control studies were included. A further 25 articles were retrieved for background information.
Conclusion: There was insufficient evidence to support a role of HHV-6 in MS onset and progression.
Brief communication (Original). Correlation of glycated albumin with self blood glucose monitoring in diabetic patients on hemodialysis taking erythropoietin
Authors: Bador Khalidah M. , Kamaruddin Sharifah K.A. , Yazid Norita T. 
Published: August 2015

Abstract
Background: Serum glycated albumin (GA) is a marker of glycemic control in diabetic renal patients, but studies were limited by the use of few random glucose values to define glycemic control.
Objectives: To determine whether GA correlated with self blood glucose monitoring is better than HbA1c in hemodialyzed diabetic patients taking erythropoietin.
Methods: This was a cross-sectional study of diabetic patients on hemodialysis with and without erythropoietin. GA was measured by ELISA and HbA1c by ion-exchange HPLC. GA was reported as the GA/albumin ratio where albumin was measured using bromocresol green. The average capillary blood glucose level over the preceding three months (CBG) was calculated from self-reported daily prebreakfast, prelunch, and prebed glucose meter readings.
Results: Thirty-four patients were recruited; 18 were taking erythropoietin (6000 units per week) and 16 had never received erythropoietin. HbA1c correlated poorly with CBG in patients taking erythropoietin (r = -0.014, P = 0.96) compared with patients without erythropoietin (r = 0.579, P = 0.02). The correlation of GA/albumin ratio with CBG in the erythropoietin group (r = 0.612, P = 0.007) was similar to the nonerythropoietin group (r = 0.854, P < 0.001). The slope for HbA1c versus CBG was 2.8-fold greater in patients without erythropoietin compared with those taking erythropoietin. There was no significant difference in the slopes for GA/albumin ratio versus CBG between the two patient groups (P > 0.05).
Conclusion: In diabetic patients on hemodialysis and taking low doses of erythropoietin, GA/albumin is a better marker of glycemic control than HbA1c.
Brief communication (Original). Correlation between liver signal intensity in hepatobiliary phase of Gd-EOB-DTPA enhancement and liver function reserves
Authors: Tanpowpong Natthaporn , Phewplung Teerasak 
Published: August 2015

Abstract
Background: Gadolinium diethylenetriamine-pentaacetic acid (Gd-EOB-DTPA) is a developed agent with preferential uptake by hepatocytes. A rapid and specific hepatocyte uptake with biliary excretion was observed of approximately 50% of the injected dose. The amount of contrast uptake is thought to be related to reserve liver function.
Objectives: To evaluate correlation between liver signal intensity in the hepatobiliary phase of Gd-EOB-DTPA and reserved liver function by using the model score for end-stage liver disease (MELD).
Methods:All patients who underwent magnetic resonance (MR) imaging with Gd-EOB-DTPA were retrospectively collected. The patients with serum creatinine level higher than 1.5 mg/dL or patients without available data to estimate MELD score were excluded. Thirty-six patients were enrolled. A signal-to-noise ratio (SNR) in the liver parenchyma on a fat-suppressed three dimensional fast spoiled-gradient recalled echo sequence images before and 20 minutes after contrast injection were measured and calculated on PACS by two radiologists. The MELD score was determined and interobserver reliability was estimated.
Results: Among 36 patients, we found a negative relationship between the percentage enhancement and the MELD score (P < 0.01, r = 0.545). The SNR at 20 minutes after Gd-EOB-DTPA injection also had a negative relationship with the MELD score with statistical significance (P < 0.01, r = 0.460). Interobserver reliability was 0.675.
Conclusion: The percentage enhancement in hepatobiliary phase of Gd-EOB-DTPA can predict reserved liver function.
Clinical report. Primary granulocytic sarcoma: a rare presentation of an ovarian mass
Authors: Chamnanchanunt Supat , Nakhakes Chajchawan , Thungthong Pravinwan , Suwanban Tawatchai , Iam-arunthai Kunapa , Sukgasi Napat , Sutherat Maleerat 
Published: August 2015

Abstract
Background: Primary granulocytic sarcoma (GS) only rarely presents with an ovarian mass classified as extramedullary myeloid progenitor tumor cells. Few patients with cases of primary GS survive after systemic chemotherapy.
Objective: To present a case of primary GS treated with complete course of chemotherapy. The patient is currently in complete remission.
Methods: Retrospective review of medical records and comparison with previous case reports.
Results: A 41-year-old woman presented with an ovarian mass of 6 months duration. There was no previous history of hematologic disease or presence of leukemic cells in other organs at the time of diagnosis. Immunohistochemistry confirmed the diagnosis. She received complete course of chemotherapy, after which complete remission was achieved.
Conclusion: A case of primary granulocytic sarcoma of the ovary was successfully treated with chemotherapy. This disease needs careful diagnosis and appropriate treatment for a good outcome.
Evaluating Progress in the Global Surgical Crisis: Contrasting Access to Emergency and Essential Surgery and Safe Anesthesia Around the World
Authors: Merchant Amina , Hendel Simon , Shockley Ross , Schlesinger Joseph , Vansell Hilary , McQueen Kelly 
Published: August 2015

AbstractIntroductionSince 2007, observations reveal that low‐ and middle‐income countries (LICs and LMICs) experience similar surgical access and safety issues, though the etiology of these challenges varies by country. The collective voice of surveys completed to date has pushed the agenda for the inclusion of safe surgery and anesthesia within global health discussions. Comparison of four countries across the world shows similar basic progress as well as ongoing surgical and anesthesia needs in resource‐challenged countries. By studying these common needs, a comprehensive plan to provide infrastructure and personnel support can work in multiple austere settings.MethodsA standardized survey tool published, designed, and developed initially by the Harvard Humanitarian Initiative and modified at Vanderbilt University was completed in Guatemala, Guyana, Laos, and Mozambique. The survey assessed eight key areas of essential surgical care: access to and availability of surgical services, access to human resources, essential infrastructure (including access to water, electricity, sanitation, blood products, and essential medicines including supplemental oxygen), surgical outcomes, operating room information and procedures, equipment, International Organization, and Non‐Government Organization provision of surgical care. These results were compared and contrasted to evaluate resource challenges and assets in each country.ResultsA total of 49 hospitals were surveyed in this comparison cohort. The results reveal common needs for emergency and essential surgery in each country, but some differences in human and capital resources exist. While minimal resources exist, all surgical sites provided running water, electricity, and oxygen—assets not seen in previous surveys as recent as 2011.ConclusionThe most basic needs to provide essential surgery are now present in LICs and LMICs. Many more resources are needed to ensure access to safe surgery and anesthesia. The next steps to provide essential surgery must include common solutions for access to surgery and anesthesia, and an evaluation of patient safety in these endeavors through the perioperative mortality rate.
Klassifizierung von „variants of unknown significance“ (VUS) beim familiären Brust- und Eierstockkrebs
Authors: Hauke Jan , Engel Christoph , Wappenschmidt Barbara , Müller Clemens R. , Hahnen Eric 
Published: August 2015

Zusammenfassung
Die Anwendung von NGS-basierten Verfahren in der molekulargenetischen Diagnostik wird in den nächsten Jahren zur Identifikation einer Vielzahl von Varianten mit unklarer Signifikanz (VUS) führen, deren Relevanz für den untersuchten Phänotyp bestimmt werden muss. In der Diagnostik erblicher Tumorprädispositionserkrankungen wird die VUS-Klassifizierung insbesondere in non-BRCA1/2-Genen in den nächsten Jahren einen hohen Stellenwert einnehmen, eine Herausforderung, die jedoch insbesondere durch internationale wissenschaftliche Kooperationen bewältigt werden kann. Das Deutsche Konsortium Familiärer Brust- und Eierstockkrebs (GC-HBOC) verwendet zur Klassifikation dieser Varianten das international etablierte IARC 5-Klassen-System und kooperiert zur Bewertung seltener Varianten sowie Varianten in bislang weniger gut untersuchten Genen mit zahlreichen internationalen Konsortien und Forschungsgruppen. Vorhersageprogramme können im Kontext von Forschungsprojekten ein nützliches Werkzeug bei der Bewertung beispielsweise der großen Zahl von Varianten in NGS-basierten Untersuchungen sein. Im Rahmen der molekulargenetischen Diagnostik sollte die Klassifizierung der identifizierten Varianten jedoch nicht ausschließlich aufgrund der Vorhersageprogramme erfolgen.
Baseline higher peritoneal transport had been associated with worse nutritional status of incident continuous ambulatory peritoneal dialysis patients in Southern China: a 1-year prospective study
Authors: Liu Yun , Huang Rong , Guo Qunying , Yang Qiongqiong , Yi Chunyan , Lin Jianxiong , Yu Xueqing , Yang Xiao 
Published: August 2015

The aim of the present study was to investigate the relationship between baseline peritoneal transport types and nutritional status in Chinese continuous ambulatory peritoneal dialysis (CAPD) patients. In the present single-centre, prospective study, incident CAPD patients were included from 15 April 2010 to 31 December 2011 and were followed up for 12 months. According to the results of baseline peritoneal equilibration test, patients were divided into lower peritoneal transport group (lower transporters) and higher peritoneal transport group (higher transporters). Nutritional status was evaluated by both subjective global assessment (SGA) and protein–energy wasting (PEW) score. The body composition parameters were assessed by body impedance analysis. A total of 283 CAPD patients were included in the study, of which 171 (60·4 %) were males with a mean age of 47·0 (sd14·9) years. Compared with lower transporters (n92), higher transporters (n181) had lower levels of serum albumin (37·1 (sd4·3)v.39·6 (sd4·3) g/l,P< 0·001), serum pre-albumin (356 (sd99)v.384 (sd90) mg/l,P= 0·035), phase angle (6·15 (sd0·39)v.6·27 (sd0·47)°,P< 0·05) and higher rate of malnutrition defined by SGA (52·5v.25·0 %,P< 0·001) and PEW score (37·0v.14·1 %,P< 0·001) at 1-year of follow-up. Baseline higher peritoneal transport, analysed by multivariate binary logistic regressions, was independently associated with malnutrition (SGA mild to moderate and severe malnutrition: OR 3·43, 95 % CI 1·69, 6·96,P< 0·01; PEW: OR 2·40, 95 % CI 1·08, 5·31,P= 0·03). It was concluded that baseline higher peritoneal transport was independently associated with worse nutritional status of CAPD patients in Southern China.
Famine and the female mortality advantage: sex, gender and mortality in northwest England, c. 1590–1630
Authors: HEALEY JONATHAN 
Published: August 2015

ABSTRACTStudies of modern famines have found disproportionately high mortality amongst adult men. The most commonly suggested root of this ‘female mortality advantage’ is biological, and it seems to be strongest when starvation is the main cause of death. The present study is the first to investigate the phenomenon in an early-modern society. Looking at the famines of 1597 and 1623 in northwest England, it finds some evidence for a female mortality advantage in 1623, but that this was concentrated in the first 12 months of the crisis (after the 1622 harvest). The female advantage was also much greater in north Lancashire and Westmorland than it was in the wealthier western Lancashire plain. Together this supports the idea that there was actual starvation during the 1623 crisis, at least in these areas at these times. There are, however, some reasons to suppose that the most mortal phase of the crisis, around the winter of 1623–1624, took place at a time when food was becoming more widely available, and hence should be attributed to diseases that followed the famine.
How dependent were the ‘dependent poor’? Poor relief and the life-course in Terling, Essex, 1762–1834
Authors: FRENCH HENRY 
Published: August 2015

ABSTRACTDespite the volume of research on the Old Poor Law, only in the last two decades have detailed local studies begun to assess the impact of relief payments across the life-courses of individuals. Their conclusions have been mixed. While many have found that the rural labouring poor of southern England were increasingly frequent recipients of poor relief after the 1780s, recent studies have indicated that ‘dependence’ on relief was generally intermittent, not permanent. Based on a new dataset for the Essex village of Terling, this study sets individual life-histories within the broader chronology of change to show how young, able-bodied men and women became relief recipients much more often after 1795 than they had before.
The usual suspect: worker migration and law enforcement in mid-nineteenth-century Anatolia
Authors: PAZ OMRI 
Published: August 2015

ABSTRACTTrials held in Anatolia around the mid-nineteenth century suggest that labour migrants became ‘the usual suspects’ in felony cases. Since the 1980s, a significant body of work on migration has emerged. Uncovering the voices of individual migrants has been a major endeavour of these studies. By following a legal case concerning one labour immigrant, and applying the methods of microhistory, this article aims to show how a socio-legal reading of migration is useful in reconstructing the history of immigrants, especially in the nineteenth century, when migration became a legal issue. Second, the article aims to demonstrate the potential of diaspora theory for analysing and explaining the experience of labour immigrants from the Balkans and the Aegean Islands during the nineteenth century, among them the protagonist of this paper.
Granaries (pósitos): a source of finance for Spain's small farmers, 1900–1950
Authors: MARTÍNEZ-SOTO ÁNGEL PASCUAL , MARTÍNEZ-RODRÍGUEZ SUSANA 
Published: August 2015

ABSTRACTUnder the Ancien Régime in Spain local granaries (in Spanish, pósitos) acted as welfare institutions designed to help small farmers in times of crisis. During the first third of the twentieth century they were subject to an intense reorganisation in Spain and this transformed them into the only microfinance institution to which a significant part of the country's rural population had access. However, as the granaries were beginning to get their finances in order, the outbreak of the Spanish Civil War (1936–1939) and the ensuing change in political regime meant that from 1950 onwards they found themselves relegated to the financial margins. The longevity of the granaries makes them an interesting example of a type of financial institution that was able to adapt to different political regimes by changing the way they operated while maintaining their core objective of supporting small farmers.