bluuebunny/crossref_metadata_2025_split huggingface dataset:
An open-label, multicenter phase 1 study to characterize safety, tolerability, preliminary antitumor activity, pharmacokinetics, and pharmacodynamics of VIP943 monotherapy in patients with advanced CD123+ hematologic malignancies.
Authors: Strickland Stephen Anthony , Curran Emily K. , Jamy Omer Hassan , Percival Mary-Elizabeth , Johnson Amy J. , Birkett Joseph , Huang Xin , Frigault Melanie M. , Lerchen Hans-georg , Stelte-Ludwig Beatrix , Navarro Tasheda , Peck Jim , Gross Wyatt , Izumi Raquel , Hamdy Ahmed M. , Daver Naval Guastad 
Published: July 2024

TPS3167 Background: VIP943 is an anti-CD123 antibody-drug conjugate (ADC) with a unique linker cleaved only by legumain and a novel kinesin spindle protein inhibitor payload. The linker-payload was engineered to increase the therapeutic index thereby improving efficacy and reducing severe toxicities compared with current ADCs. In an in vivo MOLM-13 model, VIP943 had statistically significant (p <0.001) improvement in tumor growth inhibition compared with the only ADC approved for the treatment of acute myeloid leukemia (AML), gemtuzumab ozogamicin (GO). In a nonhuman primate (NHP) single dose toxicology study, VIP943 (20 mg/kg) showed no signs of toxicity as measured by hematology, serum chemistry and survival. In contrast, NHP treated with a single dose of GO (3 mg/kg) had significant toxicity including death and mandatory euthanasia. The single-dose toxicity of GO was ameliorated by substituting the VIP943 proprietary linker and payload on an anti-CD33 antibody (3 mg/kg) as measured by hematology, serum chemistry and survival. (1,2). Methods: This trial in progress (NCT06034275) is an open-label, multicenter, Phase 1, first-in-human (FIH), dose-escalation and dose-optimization study of VIP943 in subjects with relapsed or refractory CD123+ hematologic malignancies including AML, myelodysplastic syndrome, and B-cell acute lymphoblastic leukemia. A cycle of VIP943 treatment is 28 days of once weekly intravenous infusions with no pause between cycles. The dose-escalation portion of this study follows a standard 3+3 design. Dose escalation decisions will be made by the safety review committee, and decisions will be based on the incidence of dose-limiting toxicities (DLTs). Based on FDA guidance, a dose-optimization portion of this study will randomize subjects into ≥2 dose cohorts to derive a recommended dose range for Phase 2. The study will also characterize the pharmacokinetics of VIP943 and its components and explore potential biologic activity by assessing pharmacodynamic/exploratory biomarkers, and antitumor activity using standard response criteria. As this is a FIH study, only subjects with CD123+ hematologic malignancies who have exhausted all available therapies or are not fit for standard of care can be enrolled. The results from this study will form the basis for decisions for future studies. Enrollment for cohorts 1 (no DLTs) and 2 (safety review ongoing) has completed. 1. Stelte-Ludwig et al ASH 2022. 2. Stelte-Ludwig et al ASH 2023. Clinical trial information: NCT06034275 .
ICU Management of Post-Craniotomy Patients with Schwannoma Vestibular Tumor Removal
Authors: Pratama Andhika Marthsyal , Widodo Untung 
Published: July 2024

Background: Vestibular schwannoma (VS) is a relatively common tumor that arises from the vestibulocochlear nerve (CN VIII) and represents 80% of cerebellopontine angle (CPA) masses. CPA tumors are mostly benign, slow growing with low malignant potential (~1%). VS have rarely been reported, and there is a lack of in-depth discussion on the experience of management of massive acoustic neuromas in ICU. It represents the case in which the patient presented with obstructive hydrocephalus and progressive neurological deficits. The purpose of this case report is to understand the management of post-operative patients with VS with several comorbidities in the ICU.Case: We present a 53 years old woman with a giant VS and obstructive hydrocephalus. An imaging findings revealed a brain tumor in the CPA region and obstructive hydrocephalus. Consequently, she relieved her hydrocephalus with a ventriculoperitoneal shunt (VP shunt). After 1.5 years, her mental condition deteriorated, and her left limb muscle strength gradually decreased. Under a joint consultation with Department of Neurosurgery and Anesthesiology, she underwent tumor removal. Upon discharge, the previously observed neurological deficits, which were reversible had been successfully resolved. The neuroimaging confirmed the complete tumor removal, while the neuropathologic examination revealed a VS.Discussion: If untreated, an acoustic neuroma can grow large enough to cause pressure on the brain stem. The tumor can block the flow of cerebrospinal fluid (CSF) between the brain and the spinal cord, causing a buildup of the fluid in the brain. Because the skull is a closed structure, excess fluid in the brain (hydrocephalus) can press against the brain, causing unsteady movement and lack of coordination (ataxia), headaches and confusion. Patients with brainstem compression had significantly longer mean LOS than patients without. Also, the dissection of the facial nerve from the tumor in order to preserve it can sometimes cause swelling, which can result in weakness or paralysis (complete or partial loss of muscle function). This is usually temporary but can take weeks to months to recover. After the operation, the patient was treated in the ICU, a ventilator was installed,insulin was given to regulate blood sugar and anti-hypertension medication for maintaining blood pressure. During treatment in the ICU, adequate fluids and nutrition are provided. Monitoring is carried out on cardiovascular function, hemodynamics and respiration by monitoring blood pressure, electrocardiogram (ECG), oxygen saturation. The patient was moved to high care unit (HCU) after being treated for 3 days in the ICU.Conclusion: Postoperative therapy is more focused on supportive therapy, including maintaining the airway, regulating blood sugar, blood pressure and providing mechanical ventilation to maintain adequate oxygenation.
Enhancing communication: Deep learning for Arabic sign language translation
Authors: Hassan Mosab A. , Ali Alaa H. , Sabri Atheer A. 
Published: July 2024

Abstract
This study explores the field of sign language recognition through machine learning, focusing on the development and comparative evaluation of various algorithms designed to interpret sign language. With the prevalence of hearing impairment affecting millions globally, efficient sign language recognition systems are increasingly critical for enhancing communication for the deaf and hard-of-hearing community. We review several studies, showcasing algorithms with accuracies ranging from 63.5 to 99.6%. Building on these works, we introduce a novel algorithm that has been rigorously tested and has demonstrated a perfect accuracy of 99.7%. Our proposed algorithm utilizes a sophisticated convolutional neural network architecture that outperforms existing models. This work details the methodology of the proposed system, which includes preprocessing, feature extraction, and a multi-layered CNN approach. The remarkable performance of our algorithm sets a new benchmark in the field and suggests significant potential for real-world application in assistive technologies. We conclude by discussing the impact of these findings and propose directions for future research to further improve the accessibility and effectiveness of sign language recognition systems.
Effects of CFRP sheets on the flexural behavior of high-strength concrete beam
Authors: Abduljabbar Rawya A. , Alkhafaji Sura F. , Abdulaali Hayder S. , Abdulqader Ali , Alqawzai Shagea 
Published: July 2024

Abstract
The aim of this study is to evaluate numerically the effects of carbon fiber-reinforced polymer (CFRP) sheets strengthening on the flexural performance of high-strength concrete (HSC) beam using ABAQUS 3D finite element (FE) modeling software. The developed FE models were verified against the experimental results found in literature. The FE models can accurately estimate the performance of CFRP-strengthened high-strength reinforced concrete (RC) beams. Subsequent parametric analysis was performed to assess the performance of CFRP-strengthened concrete beams considering various parameters including compressive strength of concrete, CFRP width, thickness, length, number of CFRP layers, and CFRP strengthening schemes. Based on the results of FE analysis. It was demonstrated that using HSC significantly enhances the performance of CFRP-strengthened RC beams. It was also confirmed that width, thickness, and layer number of CFRP sheets improve the flexural behavior of CFRP-strengthened HSC beams by increasing the ultimate loads and strain-hardening behavior of the specimens. The strengthening schemes contribute to delaying or inhabiting the debonding especially when the CFRP sheets are added along the bottom of the beams. It was demonstrated that using CFRP sheets U-wrapping contributes to the prevention or delay of debonding and increases the capability of resisting the stress imposed on the concrete. Therefore, installing the CFRP sheets at the bottom face of beam below the tensile reinforcement enhances the performance of CFRP-strengthened HSC beams.
Religious Education and Ecumenical Formation in Post-confessional Settings – Essentials for the Theological Education of Pastors and Teachers of Religion
Authors: Werner Dietrich 
Published: July 2024

Abstract
The article discusses the significance of international discourse on ecumenical formation for debates about the future of religious education in diverse environments, both from a German and global perspective. It emphasizes the historical importance of education in the ecumenical movement, tracing back to the early pioneers with a background in the World Student Christian Fellowship. The author draws from his longstanding involvement in international ecumenical work on education to advocate for ecumenical formation for students of theology, including those training to be religious education teachers. The article surveys key policy documents from German and international church bodies and concludes with six essential learnings for theological education in post-confessional environments.
On the Laplacian index of tadpole graphs
Authors: Braga Rodrigo O. , Veloso Bruno S. 
Published: July 2024

Abstract
In this article, we study the Laplacian index of tadpole graphs, which are unicyclic graphs formed by adding an edge between a cycle

C

k

{C}_{k}

and a path

P

n

{P}_{n}

. Using two different approaches, we show that their Laplacian index converges to

Δ

2

Δ
−
1

=

9

2

\frac{{\Delta }^{2}}{\Delta -1}=\frac{9}{2}

as

n
,
k
→
∞

n,k\to \infty

, where

Δ
=
3

\Delta =3

is the maximum degree of the graph. This limit is known as the Hoffman’s limit for the Laplacian matrix. The first technique is a linear time algorithm presented in [R. Braga, V. Rodrigues, and R. Silva, Locating eigenvalues of a symmetric matrix whose graph is unicyclic, Trends in Comput. Appl. Math. 22 (2021), no. 4, 659–674] that diagonalizes the matrix preserving its inertia. Here, we adapt this algorithm to the Laplacian index of a tadpole graph. The second method is to apply a formula presented in [V. Trevisan and E. R. Oliveira, Applications of rational difference equations to spectra graph theory, J. Difference Equ. Appl. 27 (2021), 1024–1051] for solving rational difference equations that appear when applying the diagonalization algorithm in some cases.
Gadolinium spin dilution in the ferromagnetic solid solutions Gd2–x
Y
x
Cu2Mg
Authors: Reimann Maximilian Kai , Pröbsting Wilma , Block Theresa , Pöttgen Rainer 
Published: July 2024

Abstract
Samples of the solid solution Gd2–x
Y
x
Cu2Mg (in steps of x = 0.2) were synthesized from the elements in sealed tantalum ampoules in a high-frequency furnace. The polycrystalline samples were characterized by X-ray powder diffraction. The structure of Gd0.988(6)Y1.012(6)Cu2Mg was refined from single-crystal X-ray diffractometer data: Mo2B2Fe type, P4/mbm, a = 762.83(4), c = 375.48(2) pm, wR2 = 0.0277, 285 F
2 values and 13 variables. Single-crystal data gave no hint for Gd/Y ordering. All samples behave like Curie-Weiss paramagnets with stable trivalent gadolinium and ferromagnetic ordering at low temperature. Within the solid solution the Curie temperature drops almost linearly from T
C = 113.5(1) K for Gd2Cu2Mg to 9.3(1) K for Gd0.2Y1.8Cu2Mg, allowing a precise adjustment of the magnetic ordering temperature through gadolinium spin dilution.
Dampak Stigma terhadap Akses Pelayanan Kesehatan
Authors: Permata Yesti , Kodriati Nurul 
Published: July 2024

Abstrak
Penelitian tentang stigma yang berhubungan dengan kesehatan sudah mulai banyak dipublikasikan dalam jurnal-jurnal nasional terakreditasi terutama dalam kurun waktu 8 tahun terakhir. Namun belum ada telaah terhadap artikel-artikel penelitian tentang dampak stigma terhadap akses pelayanan kesehatan. Tujuan dari penelitian ini adalah untuk mendapatkan gambaran dampak stigma yang berhubungan dengan kesehatan terhadap akses pelayanan kesehatan. Penelitian ini menggunakan metode Systematic Literature Review (SLR) yang digunakan untuk mengidentifikasi, memilih artikel, membahas dan menganalisis artikel dan menginterpretasikan artikel-artikel pada topik dampak stigma terhadap akses pelayanan kesehatan. Proses pencarian pada enam jurnal kesehatan masyarakat dalam database Kementerian Riset dan Teknologi/Badan Riset dan Inovasi Nasional dengan kategori Sinta 1 dan Sinta 2 menghasilkan 16 artikel. Analisis deskripsi dilakukan dengan mengelompokkan artikel berdasarkan subjek, metode, penyakit yang mengalami stigma, dampak stigma yang terhadap akses pelayanan kesehatan dan rekomendasi untuk mengatasi stigma. Hasil penelitian menunjukkan bahwa stigma pada penderita suatu penyakit dapat menimbulkan penolakan untuk mengakses pelayanan kesehatan. Intervensi berupa peningkatan pengetahuan dan penerapan kebijakan kesehatan dengan mempertimbangkan stigma penting untuk dilakukan.

Abstract
Research on stigma related to health has begun to be widely published in accredited national journals, especially in the last 8 years. However, there are no articles reviews of research articles on the impact of stigma on access to health services. Therefore, the purpose of this study is to obtain an overview of the impact of health-related stigma on access to health care facilities. This study uses the Systematic Literature Review (SLR) method which is used to identify, select articles, discuss and analyze articles and interpret articles on the topic of the impact of stigma on access to health services. The results of the search process on 6 journals on Public Health in the of the Ministry of Research and Technology/National Research and Innovation Agency with categories of Sinta 1 and Sinta 2 obtained 16 articles. The analysis was conducted by grouping articles based on the subject, method, stigmatized disease, the impact of the stigma on access to health services and recommendations for overcoming stigma. The results show that stigma on sufferers of a disease may lead to refusal to access health care facilities. Interventions in the form of increasing knowledge and implementing health policies by considering health stigma are important to do.
Perbedaan Pengetahuan tentang Safety Behaviour Setelah Pemberian Video Tutorial Kepada Pekerja Persampahan
Authors: Safitri Sherli Jesinata , Wahyuningsih Anik Setyo 
Published: July 2024

Abstrak
Pekerja persampahan merupakan pekerjaan yang rentan mengalami kecelakaan kerja. Di Indonesia, jumlah kecelakaan kerja termasuk akibat bekerja mengumpulkan sampah sebanyak 234.270 kasus pada tahun 2021. Mulai tahun 2020 sampai tahun 2021 di Dinas PKPLH Kabupaten Kudus, terdapat 6 kasus Penyakit Akibat Kerja dan 16 kasus Kecelakaan Akibat Kerja yang disebabkan kurangnya pengetahuan tentang safety behaviour. Tujuan penelitian ini untuk mengetahui apakah ada perbedaan pengetahuan tentang safety behaviour pada pekerja sampah Dinas Perumahan, Kawasan Permukiman dan Lingkungan Hidup Kabupaten Kudus sebelum dan sesudah pemberian video tutorial. Jenis penelitian ini adalah penelitian kuantitatif dengan metode penelitian Pre-Eksperimen dan desain penelitian One Group Pretest-Posttest. Penelitian ini dilaksanakan pada bulan Agustus tahun 2022 dengan sampel sebanyak 62 responden. Hasil penelitian ini menunjukkan ada perbedaan pengetahuan tentang safety behaviour setelah pemberian video tutorial kepada pekerja persampahan dimana nilai Asymp. Sig. (2-tailed) 0,000 sehingga p < 0,05. Simpulan dari penelitian ini adalah ada perbedaan pengetahuan tentang safety behaviour setelah pemberian video tutorial kepada pekerja sampah Dinas Perumahan, Kawasan Permukiman dan Lingkungan Hidup Kabupaten Kudus.

Abstract
Waste workers are susceptible to workplace accidents. In 2021, the number of work-related accidents in Indonesia, including those caused by waste collection, could reach 234,270. From 2020 to 2021, there were 6 cases of Occupational Diseases and 16 cases of Occupational Accidents at the PKPLH Office of Kudus Regency due to a lack of safety behaviour knowledge. The purpose of this study was to determine whether waste workers at the Housing, Settlement, and Environment Office of Kudus Regency had different levels of safety behaviour knowledge before and after receiving video tutorials. This is a quantitative study employing the Pre-Experimental research method and the One Group Pretest-Posttest research design. This research was conducted in August 2022 with 62 participants. The results of this study indicate that there is a difference in waste workers' knowledge of safety behavior after receiving video tutorials. Sig. (2-tailed) 0.000, therefore p < 0.05. The conclusion of this study is that there is a difference in safety behaviour knowledge among waste workers of the Housing, Settlement, and Environmental Office of Kudus Regency after receiving video tutorials.
Praktik Penggunaan Alat Pelindung Diri Pada Karyawan Bagian Produksi Perusahaan Konstruksi
Authors: Yuswantoro Rico Novian , Indarjo Sofwan 
Published: July 2024

Abstrak
Badan Penyelenggara Jaminan Sosial (BPJS) Ketenagakerjaan mencatat, tahun 2020 terjadi 177.000 kasus kecelakaan kerja. Sepanjang Januari hingga September 2021, terdapat 82.000 kasus. Kasus kecelakaan kerja yang terjadi di perusahaan pada bulan Januari hingga Agustus 2022 sebanyak 7 kasus, 2 kasus yang terjadi pada 2022 disebabkan karena karyawan kurang fokus saat bekerja dan penggunaan APD yang tidak lengkap. Penelitian ini bertujuan untuk mengetahui hubungan antara motivasi, persepsi manfaat, dan persepsi hambatan dengan praktik penggunaan Alat Pelindung Diri. Jenis penelitian yang digunakan adalah penelitian observasional analitik dengan pendekatan cross sectional yang dilaksanakan pada bulan september 2022. Analisis univariat disajikan dalam tabel distribusi frekuensi dan analisis bivariat untuk meyelidiki hubungan yang terjadi antara variabel bebas dan variabel terikat dengan menggunakan uji chi square. Hasil uji chi square motivasi dengan praktik penggunaan APD (p <0,001), persepsi manfaat dengan praktik penggunaan APD (p= 0,035), persepsi hambatan dengan praktik penggunaan APD (p= 0,007). Kesimpulannya adalah ada hubungan antara motivasi, persepsi manfaat dan persepsi hambatan dengan praktik penggunaan APD.
Kata kunci: Motivasi, persepsi, praktik, alat pelindung diri.
Abstract
The Employment Social Security Administration Agency (BPJS) noted that in 2020 there were 177,000 work accident cases. From January to September 2021, there were 82,000 cases. Cases of work accidents that occurred at company in January to August 2022 there were 7 cases, 2 cases that occurred in 2022 were caused by employees not being focused at work and using incomplete PPE. The purpose of this study to determine the association between motivation, perceived benefits, and perceived barriers to the practice of using Personal Protective Equipment. The type of research used was an analytic observational study with a cross-sectional which was carried out in September 2022. Univariate is presented in the frequency distribution table and bivariate analysis to investigate the relationship that occurs between the independent variables and the dependent variable using the chi square. The results of the chi square test were motivation with the practice of using PPE (p <0,001), perceived benefits with the practice of using PPE (p= 0.035), perceived barriers with the practice of using PPE (p= 0.007). The conclusion is that there is a relationship between motivation, perceived benefits and perceived barriers to the practice of using PPE.
Keywords: Motivation, perception, practice, personal protective equipment
Analisis Faktor-Faktor yang Memengaruhi Kejadian Hipertensi
Authors: Fiana Fika Khikma , Indarjo Sofwan 
Published: July 2024

Abstrak
Hipertensi merupakan keadaan tekanan darah sistolik ≥ 140 mmHg dan tekanan darah diastolik ≥ 90 mmHg. Diperkirakan pada tahun 2021 terdapat 362.460 penderita hipertensi di Kabupaten Magelang, sementara hanya 43.053 yang mendapatkan pelayanan standar. Pada tahun 2021, Puskesmas Grabag 2 menjadi salah satu puskesmas dengan angka hipertensi tinggi yaitu 782 kasus. Tujuan penelitian untuk mengidentifikasi faktor risiko hipertensi di Puskesmas Grabag 2. Penelitian ini menggunakan metodologi observasional analitik dengan desain studi cross-sectional. Populasi penelitian sebanyak 1042 orang. Teknik pengambilan sampel menggunakan total sampling dan menggunakan data sekunder kunjungan Posbindu PTM di Puskesmas Grabag 2 pada bulan Agustus 2022. Usia (p-value 0,001) dan tingkat pendidikan (p-value 0,001) ditemukan berhubungan terhadap kejadian hipertensi, sedangkan faktor risiko lainnya tidak berhubungan. Penyuluhan tentang hipertensi sangat diperlukan, terutama bagi pasien usia lanjut, agar dapat lebih meningkatkan kualitas hidup mereka.
Kata kunci: hipertensi, faktor risiko, posbindu

Abstract
Hypertension is a condition of systolic blood pressure ≥ 140 mmHg and diastolic blood pressure ≥ 90 mmHg. It is estimated that in 2021 there will be 362,460 people with hypertension in Magelang Regency, while only 43,053 will receive standard services. In 2021, Grabag 2 Health Center will be one of the health centers with a high rate of hypertension, namely 782 cases. The research objective was to identify the risk factors for hypertension at the Grabag 2 Health Center. This study used an analytic observational methodology with a cross-sectional study design. The research population was 1042 people. The sampling technique used total sampling and used secondary data from PTM Posbindu visits at the Grabag 2 Health Center in August 2022. Age (p-value 0.001) and educational level (p-value 0.001) were found to be related to the incidence of hypertension, while other risk factors were not related. Education about hypertension is very necessary, especially for elderly patients, in order to further improve their quality of life.
Keywords: hypertension, risk factors, posbindu