bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adaptive Bayesian Analysis of Serum Creatinine as a Marker for Drug-Induced Renal Impairment in an Early-Phase Clinical Trial
Authors: Sottas Pierre-Edouard , Kapke Gordon F , Leroux Jean-Marc 
Published: September 2012

BACKGROUND
A concern with using creatinine for the identification of drug-induced renal impairment is that small changes in serum creatinine (SCr) that frequently are perceived as measurement bias or imprecision translate into important changes in the glomerular filtration rate. Important drug-generated changes in creatinine are difficult to detect because they are frequently observed within the reference interval. The design of a crossover drug protocol is an opportunity to use study participants as their own control to identify these small but important changes.

METHODS
Twenty individuals participating in a phase I clinical trial were evaluated for SCr changes beyond those expected for biological variation according to individual Z scores derived from an adaptive Bayesian model. After 2 screening tests, participants were administered either drug (n = 11) or placebo (n = 9) during the first dosing interval. A washout period followed, and drug was then administered to the group that initially received placebo, and vice versa (10 visits total per participant).

RESULTS
Although all creatinine values fell within the reference interval, 8 participants individually showed increased concentrations (Z scores &gt;2.33). These 8 participants were confirmed at unblinding to have received the drug in the identified dosing period, with 1 exception.

CONCLUSIONS
The ability to identify a drug effect on an individual-participant basis in early-phase studies permits drug developers to recognize issues early in development and rapidly engage in risk–benefit analysis. These results suggest that SCr monitoring is able to detect early kidney dysfunction when individual-based reference intervals are used.
Intestinal permeability and fecal eosinophil-derived neurotoxin are the best diagnosis tools for digestive non-IgE-mediated cow’s milk allergy in toddlers
Authors: Kalach Nicolas , Kapel Nathalie , Waligora-Dupriet Anne-Judith , Castelain Marie-Christine , Cousin Marie Odile , Sauvage Christine , Ba Fatimata , Nicolis Ioannis , Campeotto Florence , Butel Marie José , Dupont Christophe 
Published: September 2012

Abstract

Background: Food allergy is a common problem in France involving 4%–6% of toddlers. As opposed to IgE-mediated cow’s milk allergy (CMA), delayed-onset CMA, mostly, non-IgE-mediated, remains difficult to diagnose in toddlers. Our study assessed the diagnostic performances of intestinal permeability and of fecal markers, in comparison with the standard allergic work-up in children referred for CMA diagnosis.

Methods: Twenty-five consecutive children, mean age (standard deviation) 6.3 months (4.8) with digestive and/or extra-digestive manifestations suggesting CMA, were prospectively studied based on a standardized allergic work-up (specific cow’s protein IgE and IgG, skin prick test, atopy patch test and oral open cow’s milk challenge) and digestive work-up including fecal microbiota analysis, intestinal permeability determination (urinary lactitol/mannitol ratio) and fecal markers measurement, i.e., α1-antitrypsin, tumor necrosis factor-α, calprotectin, β-defensin2, secretory IgA and eosinophil-derived neurotoxin (EDN). Receiver operating characteristic (ROC) curves were calculated for all markers in order to define cut-off levels.

Results: The cow’s milk challenge was positive in 11 children and negative in 14. The global test performances, i.e., the number of true positive+negative cases/the total number of cases, were 76% for intestinal permeability; 72% for fecal EDN; contrasting with atopy patch test, 68%; IgE, 60%; skin prick test, 55% and IgG, 52%.

Conclusions: In this routine diagnosis allergy work-up for CMA in toddlers, the best efficacy was seen for intestinal permeability compared to IgE, IgG, skin prick test and atopy patch test. Moreover, fecal EDN in a single spot sample displayed a similar performance.
Studying thermal conductivity of wood at cell wall level by scanning thermal microscopy (SThM)
Authors: Vay Oliver , Obersriebnig Michael , Müller Ulrich , Konnerth Johannes , Gindl-Altmutter Wolfgang 
Published: September 2012

Abstract
Local variability in the thermal conductivity of the cell wall of beech wood fibers was studied by means of scanning thermal microscopy (SThM). In the cross section, the thermal conductivity of the secondary cell wall was essentially higher than that of the compound middle lamella (CML). In sections parallel to the cell axis, the overall conductivity of the S1 layer was lower than that of the secondary cell wall, but the S2 layer and the CML showed similar conductivities. This is attributed to the orientation of the cellulose microfibrils playing a key role in the observed anisotropies concerning the thermal conductivity. The deviating thermal conductivities on different sections are attributed to the depth effect of the thermal scanning. SThM proves to be a technique with considerable potential for wood research.
Crystal structure of (2S, 4R)-2-benzyl 1-tert-butyl 4-(tosyloxy)pyrrolidine- 1,2-dicarboxylate, C24H29NO7S
Authors: Ghosh Munmun , Mallick Arijit , Díaz David Díaz 
Published: September 2012

Abstract
C24H29NO7S, triclinic, P1 (no. 1) , a = 6.5903(3) Å, b = 9.7193(5) Å, c = 9.9874(4) Å, α = 82.462(4)°, β = 77.197(3)°, γ = 85.6180(4)°,V = 617.7 Å3, Z = 1, Rgt(F) = 0.0351, wRref(F2) = 0.0967, T = 123 K.
Crystal structure of aqua-[(2,2'-bipyridine)]-[(2,4-dihydroxypyrimidine- 5-carboxylato)] perchloratocopper(II), Cu(H2O)(C10H8N2)(C5H3N2O4)(ClO4), C15H13ClCuN4O9
Authors: Liu Qi , Xiao Bo , Chen Min-Dong 
Published: September 2012

Abstract
C15H13ClCuN4O9, monoclinic, P21/n (no. 14), a = 8.1493(3) Å, b = 11.4761(4) Å, c = 19,3483(6) Å, β = 97.7438(3)°, V=1793.05(11)Å3, Z=4,Rgt(F)=0.0459,wRref(F2)=0.1149, T = 296 K
Design of Π-conjugated Graft and Block Copolymers: A Tool Box for Nanostructured Materials in Optoelectronic Devices
Authors: Brochon Cyril , Mougnier Sebastien-Jun , Cloutet Eric , Hadziioannou Georges 
Published: September 2012

ABSTRACTSemi-conducting conjugated (co)polymers are well soluble and can be processed easily in a large scale. Among these materials, rod-coil block and graft copolymers, show very particular properties of self-assembly, and are very promising in organic electronic, as organic photovoltaic materials for example.The post-functionalization of poly(3-hexylthiophene) (P3HT) from ω-allyl terminated P3HT via various synthetic routes is reported in order to obtain well-defined block and graft copolymers for optoelectronic or photovoltaic applications. First, a well-defined and monofunctional P3HT-based macro-initiator has been obtained through a clean and versatile process. Well-defined rod-coil block copolymers were obtained by nitroxide mediated radical polymerization (NMRP) with various monomers. Finally, three different novel P3HT-based graft copolymers were synthesized following two routes.
Surface modification of bacterial magnetic nanoparticles using artificial polypeptides consisting of a repeated asparagine-serine dipeptide and a transmembrane peptide
Authors: Honda Toru , Yoshino Tomoko , Tanaka Tsuyoshi , Matsunaga Tadashi 
Published: September 2012

ABSTRACTSurface modification is an important part of fabricating nanoparticles with specific properties and functions. We have designed a dipeptide, which we call NS polypeptide, that consists of four asparagine (N) residues and one serine (S) residue, as a molecule for nanoparticle surface modification. Surface modification of magnetic nanoparticles with the NS polypeptide results in reduction of particle-particle and particle-cell interactions. Here, we describe the surface modification and functionalization of bacterial magnetic particles (BacMPs) by spontaneous integration of temporin L conjugated to NS polypeptide. BacMP membranes were modified temporin L. Furthermore, peptide-modified BacMPs showed high dispersibility in aqueous solution compared to unmodified BacMPs. This surface modification technique may represent a new strategy for reducing non-specific binding of nanoparticles to proteins or cells for use in a variety of protein- or cell-associated applications.
Evaluation of Infection Resistance of Biological Implants through CMP based Micro-Patterning
Authors: Basim G. Bahar , Ozdemir Zeynep , Karagoz Ayse 
Published: September 2012

ABSTRACTBiomaterials are widely used for dental implants, orthopedic devices, cardiac pacemakers and catheters. One of the main concerns on using bio-implants is the risk of infection on the materials used. In this study, our aim is to quantify the effect of controlled surface roughness on the infection resistance of the titanium based bio-materials which are commonly used for orthopedic devices and dental implants. To modify the surface roughness of the surfaces in a controlled manner, Chemical Mechanical Polishing (CMP) technique, which is extensively used in semiconductor industry for the planarization of the interlayer dielectrics and metals, is utilized. To determine the infection resistance of the created films with varying surface roughness, bacteria growth response was studied on titanium plates after CMP.
Comparative study of corrosion and tribocorrosion resistance of some biomaterials
Authors: Takadoum J. , El Mansouri J. , Ivanescu S. , Stanciu D. 
Published: September 2012

ABSTRACTCorrosion and tribocorrosion tests have been conducted on titanium, Ti-6Al-4V and Ti-10Zr-10Nb-5Ta alloys. The experiments have been conducted in four different electrolytes: NaCl solution, Ringer’s solution, phosphate buffered saline solution (PBS) with and without an addition of bovine serum albumin (BSA).The electrochemical study showed that, whatever the electrolyte, the passivating film formed on Ti-10Zr-10Nb-5Ta surface is more stable than those obtained on the surface of titanium or Ti-6Al-4V alloy. In addition, Ti-10Zr-10Nb-5Ta presents a better resistance to corrosion. In PBS solution, open circuit potential (OCP) moved to more positive value in comparison with results obtained in NaCl and Ringer’s solutions, whereas addition of BSA moved OCP value towards more negative potential indicating a detrimental effect.Tribocorrosion tests have been conducted at OCP when sliding against an alumina ball. Friction coefficient, current and volume of material removal at the end of tests have been measured and the results discussed. The influence of the presence of proteins molecules has been particularly analyzed.
Crizotinib for the Treatment of ALK-Rearranged Non-Small Cell Lung Cancer: A Success Story to Usher in the Second Decade of Molecular Targeted Therapy in Oncology
Authors: Ou Sai-Hong Ignatius , Bartlett Cynthia Huang , Mino-Kenudson Mari , Cui Jean , Iafrate A. John 
Published: September 2012

Abstract
Crizotinib, an ALK/MET/ROS1 inhibitor, was approved by the U.S. Food and Drug Administration for the treatment of anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC) in August 2011, merely 4 years after the first publication of ALK-rearranged NSCLC. The crizotinib approval was accompanied by the simultaneous approval of an ALK companion diagnostic fluorescent in situ hybridization assay for the detection of ALK-rearranged NSCLC. Crizotinib continued to be developed as an ALK and MET inhibitor in other tumor types driven by alteration in ALK and MET. Crizotinib has recently been shown to be an effective ROS1 inhibitor in ROS1-rearranged NSCLC, with potential future clinical applications in ROS1-rearranged tumors. Here we summarize the heterogeneity within the ALK- and ROS1-rearranged molecular subtypes of NSCLC. We review the past and future clinical development of crizotinib for ALK-rearranged NSCLC and the diagnostic assays to detect ALK-rearranged NSCLC. We highlight how the success of crizotinib has changed the paradigm of future drug development for targeted therapies by targeting a molecular-defined subtype of NSCLC despite its rarity and affected the practice of personalized medicine in oncology, emphasizing close collaboration between clinical oncologists, pathologists, and translational scientists.
Randomized, Placebo-Controlled Comparison of Amitriptyline, Duloxetine, and Pregabalin in Patients With Chronic Diabetic Peripheral Neuropathic Pain
Authors: Boyle Julia , Eriksson Malin E.V. , Gribble Laura , Gouni Ravi , Johnsen Sigurd , Coppini David V. , Kerr David 
Published: September 2012

OBJECTIVE
Chronic diabetic peripheral neuropathic pain (DPNP) is difficult to treat, with treatment regimens often inadequate at controlling pain and limited by side effects and drug tolerance. Secondary parameters, such as quality of sleep and mood, may also be important for successful DPNP management. The objectives of this study were to compare the analgesic efficacy of pregabalin, amitriptyline, and duloxetine, and their effect on polysomnographic sleep, daytime functioning, and quality of life in patients with DPNP.

RESEARCH DESIGN AND METHODS
This was a double-blind, randomized, parallel group investigation of type 1 and 2 diabetic subjects with DPNP. Each treatment group had a single-blind, 8-day, placebo run-in followed by 14 days of lower-dose and 14 days of higher-dose medication. At the end of each dose titration period, subjective pain, sleep, and daytime functioning were assessed during a 2-day residential period.

RESULTS
All medications reduced pain when compared with placebo, but no one treatment was superior to any other. For sleep, pregabalin improved sleep continuity (P &lt; 0.001), whereas duloxetine increased wake and reduced total sleep time (P &lt; 0.01 and P &lt; 0.001). Despite negative effects on sleep, duloxetine enhanced central nervous system arousal and performance on sensory motor tasks. There were no significant safety findings; however, there was a significantly higher number of adverse events in the pregabalin treatment group.

CONCLUSIONS
There was no significant difference in analgesic efficacy between amitriptyline, duloxetine, and pregabalin. However, there were significant differences in the secondary parameters, which may be of relevance when deciding the optimal treatment for DPNP.
Equilibrium, kinetic, and thermodynamic studies of Basic Blue 9 dye sorption on agro-industrial lignocellulosic materials
Authors: Suteu Daniela , Zaharia Carmen , Malutan Teodor 
Published: September 2012

Abstract
The sorptive potential of some lignocellulosic agro-industrial wastes (sunflower seed shells and corn cob) for Basic Blue 9 cationic dye removal from aqueous solutions was examined using the batch technique. The Freundlich, Langmuir, and Dubinin-Radushkevich isotherm models were used in order to determine the quantitative parameters of sorption. The Langmuir isotherm model indicated a maximum sorption capacity for these materials in the range of 40–50 mg dye per g (25°C), slightly higher for corn cob than for sunflower seed shells. The values of the thermodynamic parameters showed that the retention of cationic dye is a spontaneous and endothermic process. The application of pseudo-first order and pseudo-second order intraparticle diffusion models, and a Boyd — Reichenberg model for kinetic data interpretation suggested that sorption of Basic Blue 9 dye onto the studied materials is a process where both surface sorption and intraparticle diffusion contributed to the rate-limiting step. These lignocellulosic wastes can be used with good efficiency for dye removal from aqueous effluents.
The supply of subglacial meltwater to the grounding line of the Siple Coast, West Antarctica
Authors: Carter S.P. , Fricker H.A. 
Published: September 2012

AbstractRecent satellite studies have shown that active subglacial lakes exist under the Antarctic ice streams and persist almost to their grounding lines. When the lowest-lying lakes flood, the water crosses the grounding line and enters the sub-ice-shelf cavity. Modeling results suggest that this additional freshwater influx may significantly enhance melting at the ice-shelf base. We examine the spatial and temporal variability in subglacial water supply to the grounding lines of the Siple Coast ice streams, by combining estimates for lake volume change derived from Ice, Cloud and land Elevation Satellite (ICESat) data with a model for subglacial water transport. Our results suggest that subglacial outflow tends to concentrate towards six embayments in the Siple Coast grounding line. Although mean grounding line outflow is ~60m3 s–1 for the entire Siple Coast, maximum local grounding line outflow may temporarily exceed 300 m3 s–1 during the synchronized flooding of multiple lakes in a hydrologic basin. Variability in subglacial outflow due to subglacial lake drainage may account for a substantial portion of the observed variability in freshwater flux out of the Ross Ice Shelf cavity. The temporal variability in grounding line outflow results in a net reduction in long-term average melt rate, but temporary peak melting rates may exceed the long-term average by a factor of three.
Federalism and the Concept of Political Territoriality
Authors: Mueller Sean 
Published: September 2012

Résumé Les questions fondamentales abordées par la politique territoriale comparée étudient pourquoi et comment le territoire est utilisé pour délimiter, maintenir et créer du pouvoir politique ; et quelles en sont les conséquences pour l’efficacité (output) et la légitimité (input). L’objet de cet article est d’intégrer différentes formes de recherche dans l’étude comparée de la politique territoriale, en considérant en son cœur les études fédérales. La « territorialité politique », conçue comme une résolution conceptuelle, renvoie l’observateur aux trois dimensions de l’utilisation stratégique des frontières terrestres dans la recherche de pouvoir politique. En se concentrant sur le territoire comme variable clé des systèmes politiques, les acteurs, processus et institutions sont tout d’abord distingués analytiquement et mesurés continuellement, pour accroître leur validité interne, et ensuite intégrés dans la théorie. Ceci permet une meilleure validation des variables externes qu’avec une approche classique, fondée sur les études fédérales légales-institutionnelles. Après avoir considéré les frontières et la substance de la politique fédérale comparée comme discipline fédérale, on développe la territorialité politique comme cadre analytique applicable à l’étude de la politique à quelque niveau gouvernemental que ce soit. Les propositions en sont modestes : la territorialité politique ne doit pas tant être utilisée comme concept explicatif des études fédérales que comme un outil visant à attirer l’attention du chercheur sur ces problématiques.
Identity-Diversity and the Territorial Dimension in the Western Balkans
Authors: Woelk Jens 
Published: September 2012

Résumé La création des États-nations dans les Balkans occidentaux après le démantèlement de la Yougoslavie a donné lieu à une plus grande demande de prise en compte de la diversité. Ce paradoxe s’explique par divers facteurs : malgré la tragédie de la violence ethnique et les tentatives de « nettoyage ethnique » durant les années quatre-vingt-dix, il n’y a pas eu d’homogénéisation de la population et la diversité est toujours la caractéristique de la plupart des (nouveaux) États dans la région. La nécessité de garantir la stabilité régionale pour les États, mais également l’importance d’assurer un vivre-ensemble pacifique dans la diversité comme indicateur d’un système démocratique vraiment pluraliste, ont conduit à différentes formes d’intervention de la part de la communauté internationale, poursuivies par la conditionnalité européenne. La principale variable que l’on peut identifier dans une étude comparée est l’utilisation du territoire pour accommoder la diversité (ethnique). En suivant le modèle d’État-nation d’Europe centrale et orientale, l’identification des groupes avec un territoire spécifique a souvent conduit à des aspirations nationalistes exclusives et à la violence ethnique ; le défi d’aujourd’hui est d’assurer la diversité, par exemple les droits de l’homme et les revendications des groupes, à l’intérieur d’un cadre territorial stable.
La mise en place des observatoires des fragilités dans le cadre d'un partenariat CNAMTS-CNAV
Authors: Blanckaert Antonin 
Published: September 2012

L’amélioration du dépistage des premiers signes de fragilité en amont de la perte d’autonomie et l’organisation d’un ciblage des actions de prévention vers les populations les plus vulnérables constituent les enjeux autour desquels la caisse nationale d’assurance vieillesse (Cnav) et les caisses d’assurance retraite et de la santé au travail (Carsat) optimisent leur politique de prévention de la perte d’autonomie, en concertation avec la caisse nationale de l’assurance maladie des travailleurs salariés (Cnamts) dans le cadre du plan de préservation de l’autonomie des personnes âgées (plan Papa), les autres régimes de sécurité sociale (ex. : mutualité sociale agricole (MSA), régime social indépendant (RSI)) et les fédérations Agirc (Association générale des institutions de retraite des cadres) - Arrco (Association pour le régime de retraite complémentaire des salariés). Ce plan Papa permet notamment d’offrir des services à des publics fragilisés et de mettre en place un comité d’experts scientifiques chargé de labelliser les actions de prévention les plus efficaces.
Prévention et vieillissement en bonne santé : un regard économique
Authors: Barnay Thomas 
Published: September 2012

En France, les mauvais résultats en termes de performance sanitaire et l’aggravation des inégalités sociales de santé, et ce en dépit d’un investissement public élevé, justifient de s’interroger sur la promotion d’actions de prévention. Cette réflexion questionne la rationalité des politiques collectives de prévention et l’adoption de comportements individuels de prévention. Au final, cet article vise à expliciter les conditions permettant de promouvoir le vieillissement en bonne santé par une prévention ciblée, coordonnée et précoce dès l’âge de 50 ans.
La politique de prévention en ARS : l'exemple du nord-pas-de-calais
Authors: Defebvre Marguerite-Marie 
Published: September 2012

La région Nord-Pas-de-Calais aux indicateurs socio-économiques défavorables à la santé fait preuve d’un dynamisme renouvelé par l’ensemble de ses acteurs de santé. La nouvelle politique de santé régionale, voulue par la loi Hôpital patients santé territoires (HPST) de 2009, qui a créé les agences régionales de santé (Ars), s’organise autour de parcours de santé reliant le champ préventif, sanitaire et l’accompagnement médico-social. Parallèlement se construit le schéma régional de prévention intégré au projet régional de santé. Il nous incite à de nouvelles réflexions au plan économique, dans un contexte contraint, mais aussi sur les pratiques, les formations et l’organisation du système de santé pour mieux répondre aux besoins des personnes atteintes de maladies chroniques et des personnes âgées.
Le Coran et ses multiples formes (Casablanca, Maroc)*
Authors: Cohen Anouk 
Published: September 2012

Le Coran se décline en une pluralité de formes. À Casablanca, dans le quartier des librairies arabes, on en trouve de différentes tailles – le grand, les moyens, le petit et le miniature –, reliés ou non, avec ou sans étui, étui en velours ou en cuir, incluant dans certains cas une fermeture éclair. Quels usages sont attachés à ces différents modèles du Coran ? Quels rôles leur font jouer les acteurs (aussi bien usagers, éditeurs que gouvernants) ? Deux interrogations au cœur de la réflexion axée sur la forme prise par le Coran – celle du livre – et sur l’analyse des matériaux à partir desquels il est confectionné, dans le but d’étudier les effets que l’apparence physique du Coran produit sur les appropriations de la parole divine.