bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Features of Body Mass Index in Late Life Predict Cognitive Trajectories and Alzheimer’s Disease: A Longitudinal Study
Authors: Wang Ruo-Tong , Sun Zhen , Tan Chen-Chen , Tan Lan , Xu Wei ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: July 2024

Background: The causal relationships of late-life body mass index (BMI) with Alzheimer’s disease (AD) remains debated. Objective: We aimed to assess the associations of dynamic BMI features (ΔBMIs) with cognitive trajectories, AD biomarkers, and incident AD risk. Methods: We analyzed an 8-year cohort of 542 non-demented individuals who were aged ≥65 years at baseline and had BMI measurements over the first 4 years. ΔBMIs were defined as changing extent (change ≤ or >5%), variability (standard deviation), and trajectories over the first 4 years measured using latent class trajectory modeling. Linear mixed-effect models were utilized to examine the influence of ΔBMIs on changing rates of AD pathology biomarkers, hippocampus volume, and cognitive functions. Cox proportional hazards models were used to test the associations with AD risk. Stratified analyzes were conducted by the baseline BMI group and age. Results: Over the 4-year period, compared to those with stable BMI, individuals who experienced BMI decreases demonstrated accelerated declined memory function ( p = 0.006) and amyloid-β deposition ( p = 0.034) while BMI increases were associated with accelerated hippocampal atrophy ( p = 0.036). Three BMI dynamic features, including stable BMI, low BMI variability, and persistently high BMI, were associated with lower risk of incident AD ( p < 0.005). The associations were validated over the 8-year period after excluding incident AD over the first 4 years. No stratified effects were revealed by the BMI group and age. Conclusions: High and stable BMI in late life could predict better cognitive trajectory and lower risk of AD.
Factors determining outcome of tactile kinesthetic stimulation in preterm neonates
Authors: Akshitha E.V.N. , Choubey B. , Shrivastava J. 
Published: July 2024

BACKGROUND: Tactile kinesthetic stimulation (TKS) has been the subject of clinical research since the 1960 s, when it was proposed as a way to promote preterm growth and development. OBJECTIVE: To find out the effect of TKS on weight gain in preterm neonates and the factors affecting TKS in relation to outcome. METHODS: TKS was demonstrated to mothers in department of paediatrics. 124 Preterm neonates fulfilling inclusion criteria were enrolled. The time for which they are doing TKS was noted. Their weight was monitored daily by digital weighing scale till discharge and at one month of age and then average weight gain was calculated and correlated with various factors. RESULTS: There is a significant increase in weight of neonates at discharge (1.73 kg; p < 0.001) and at one month (1.96 kg; p < 0.001) when compared to enrollment (1.686 kg). There was a significant positive correlation between TKS session duration and mean weight change at 1 month follow up ( r = 0.269; P = 0.003) and per day weight gain ( r = 0.889; p < 0.001), as well as a positive correlation between average TKS session and weight gain when pearson correlation was performed. TKS sessions of 15 minutes or three sessions per day were effective in increasing the weight of preterm neonates. It was noticed that those who received three sessions per day had a shorter hospital stay (7.68 days) than two sessions per day (10.23 days). The education level of the mother, care giver, type of feed, and gender of the preterm have no significant effect on weight gain.
Mental fatigue recognition study based on 1D convolutional neural network and short-term ECG signals
Authors: Chen Ruijuan , Wang Rui , Fei Jieying , Huang Lengjie , Bi Xun , Wang Jinhai 
Published: July 2024

BACKGROUND: Mental fatigue has become a non-negligible health problem in modern life, as well as one of the important causes of social transportation, production and life accidents. OBJECTIVE: Fatigue detection based on traditional machine learning requires manual and tedious feature extraction and feature selection engineering, which is inefficient, poor in real-time, and the recognition accuracy needs to be improved. In order to recognize daily mental fatigue level more accurately and in real time, this paper proposes a mental fatigue recognition model based on 1D Convolutional Neural Network (1D-CNN), which inputs 1D raw ECG sequences of 5 s duration into the model, and can directly output the predicted fatigue level labels. METHODS: The fatigue dataset was constructed by collecting the ECG signals of 22 subjects at three time periods: 9:00–11:00 a.m., 14:00–16:00 p.m., and 19:00–21:00 p.m., and then inputted into the 19-layer 1D-CNN model constructed in the present study for the classification of mental fatigue in three grades. RESULTS: The results showed that the model was able to recognize the fatigue levels effectively, and its accuracy, precision, recall, and F1 score reached 98.44%, 98.47%, 98.41%, and 98.44%, respectively. CONCLUSION: This study further improves the accuracy and real-time performance of recognizing multi-level mental fatigue based on electrocardiography, and provides theoretical support for real-time fatigue monitoring in daily life.
Faktor Yang Mempengaruhi Kualitas Hidup Pasien Diabetes Melitus Tipe 2 Di Salah Satu Layanan Kesehatan Masyarakat Kota Makassar
Authors: Kadang Yuniharce , Zulfiah  , Rusli  
Published: July 2024

Factors Affecting The Quality Of Life Of Type 2 Diabetes Mellitus Patients In One Of The Public Health Services In Makassar City
Diabetes Melitus Type 2 is a lifelong disease due to metabolic disorders where the body cannot produce insulin properly which is characterized by increased blood sugar levels (Hyperglycemia). Complications that are not treated promptly and appropriately can shorten a person's life span, thereby greatly affecting the quality of life of type 2 DM patients. The aim of this research is to analyze the factors that influence the quality of life of type 2 DM patients at the Sudiang Raya Community Health Center, Makassar City.This research method uses a cross sectional method. The research population was 120 patients diagnosed with type 2 Diabetes Melitus, with a total sampling method, a sample of 120 respondents. The data analysis used was univariate analysis with percentages, bivariate with the chis-quare testThe factor assessed was complications. The results of the study showed that complications significantly affected the quality of life of Type 2 DM patients, namely (p value = 0.015) and family support (ρ Value = 0.006)
Diabetes Melitus Tipe 2 merupakan penyakit seumur hidup karena terjadi gangguan Metabolisme dimana tubuh tidak dapat memproduksi insulin dengan baik yang ditandai meningkatnya kadar gula dalam darah (Hiperglikemia). Komplikasi yang tidak segera ditangani dengan baik dan tepat dapat menyebabkan pendeknya rentang hidup seseorang, sehingga sangat mempengaruhi kualitas hidup pasien DM tipe 2ujuan penelitian ini adalah Untuk menganalisis Faktor yang mempengaruhi kualitas hidup pasien DM Tipe 2 di salah satu layanan kesehatan kota Makassar. Metode yang digunakan adalah metode cross sectional. Populasi sebanyak 120 Responden terdiagnosa DM Tipe 2, dengan metode total sampling, sampel di ambil dari seluruh populasi. Menggunakan Analisis data Analisis univariat dengan presentase ,bivariate dengan uji chis-quare. Faktor yang dinilai adalah Komplikasi dan dukungan keluarga dimana Hasil penelitian pada komplikasi dan dukungan keluarga secara signfikan mempengaruhi Kualitas Hidup Pasien DM Tipe 2 dengan Nilai Komplikasi Yaitu (p value =0,0015) dan dukungan keluarga ( ρ Value = 0,006)
PENGEMBANGAN BEKA’ ECOTOURISM GUNA MENDUKUNG KONSERVASI KAKAKTUA KECIL JAMBUL KUNING DAN EKONOMI MASYARAKAT PULAU MASAKAMBING
Authors: Ihsannudin Ihsannudin , Sriyono Sriyono , Safi' Safi' , Kuntadi Ebban Bagus 
Published: July 2024

Masakambing island, having only one village Masakambing and located in Sumenep Regency, East Java, has area 7,79 square kilometers. This island is designated as Essential Ecosystem Area (KEE) through East Java Governor’s decree No. 188/166/2020 because it has High Conservation Valued Area (ABKT) as the habitat of endemic yellow-crested cockatoos (Caccatua sulphurea abbotti). The wildlife having local name Beka’ is critically endangered because there are only 22 birds left in the wild. Furthermore, the society in Masakambing is motivated and eager to save yellow-crested cockatoos when they have economic benefits, one of them is ecotourism. The implementation of ecotourism should refer to the preservation, the involvement of local people, and interpretation–education content while considering safety and hospitality. Accordingly, this emerges an idea of Beka’ Ecotourism development as ecotourism activity-based conservation of yellow-crested cockatoos. The development is conducted for the institutional capacity of Pokdarwis Beka’ Island in terms of institution, legality, and governance. Besides, safety assurance, interpretation-education, and hospitality such as homestay and food-beverage service and as well as promotion through social media and network connectivity are also developed
PEMANFAATAN LIMBAH KULIT BUAH NANAS (Ananas comosus (L) Merr.) SEBAGAI MINUMAN PENCERNAAN PROBIOTIK
Authors: Fadhli Haiyul , Suhery Wira Noviana , Agustini Tiara Tri , Ningsih Yozi Fiedya 
Published: July 2024

Conventional fruit processing for food and beverage production often ignores the potential benefits of fruit peels, resulting in the presence of useless waste. Pineapple peel (Ananas comosus L. Merr) is one of the most underutilized by-products, even though it contains valuable compounds such as bromelain, flavonoids, tannins, oxalates, and phytates that have antibacterial and probiotic properties. The purpose of this community service is to provide education to increase the knowledge of the Kualu Nenas Village community about the utilization of pineapple peel waste as a prebiotic drink. The method used is counseling with colored brochure media and a demonstration of making probiotic drinks. The results obtained from 50 respondents were 48 (96%) respondents with low knowledge level, 1 (2%) respondent with sufficient knowledge level, and 1 (2%) respondent with high knowledge level. The bivariate test was carried out using the Wilcoxon method, where the test obtained the results of the p value = 0.000, which can be concluded that there is a difference or there is an effect of giving brochures on public knowledge because the p value <0.005.
PEMANFAATAN LIMBAH TERNAK KAMBING DAN LIMBAH JAMUR TIRAM SEBAGAI PUPUK ORGANIK DI DESA TLAGA BANYUMAS
Authors: Sarwanto Doso , Viastika Yanita Mutiaraning , Muntahanah Siti , Ratnaningtyas Nuniek Ina , Purwantini Dattadewi , Lestari Sri 
Published: July 2024

Pelaksanaan Kolaborasi Sosial Membangun Masyarakat (Kosabangsa) pada kegiatan ini bertujuan untuk meningkatkan dan menerapkan ilmu pengetahuan dan teknologi mengenai pengomposan limbah ternak kambing dan limbah baglog jamur tiram untuk meningkatkan produksi pangan sekaligus dapat meningkatkan ketahanan pangan masyarakat. Metode yang digunakan pada pelaksanaan kegiatan ini adalah metode Participatory Action Research (PAR) dengan sasaran kegiatan adalah gabungan kelompok tani (Gapoktan) Tani Makmur Desa Tlaga, Kecamatan Gumelar, Kabupaten Banyumas. Kegiatan berupa transfer teknologi melalui kegiatan penyuluhan, pelatihan, demplot dan pendampingan serta pemberian peralatan teknolgi dan inovasi kepada gapoktan Tani Makmur. Hasil kegiatan ini adalah meningkatnya pengetahuan, ketrampilan dan meningkatnya kesuburan tanah yang pada khirnya dapat meningkatkan produktivitas tanaman pangan di Desa Tlaga.
Time Perspective and Motivation to Protective behaviours against Covid-19 in Italian young people
Authors: Zambianchi Manuela 
Published: July 2024

Health Psychology highlights the complexity of factors that influences the individual decision to adopt one, or more, protective behaviours for avoiding diseases and adverse health outcomes. One of the most relevant theory is the Protection Motivation Theory (Rogers, 1975), which has been adopted for identifying the psychological factors involved in many protection behaviours. Another relevant construct for healthy behaviours is represented by the Time Perspective (Zimbardo & Boyd, 1999). This study analysed the relationships between the Protection Motivation Theory applied on Covid-19 and Time Perspective in Italian young people.A group of 130 young people (m. age 26.4; 40 males and 90 females) participated in the study, filling in the Swedish Zimbardo Time Perspective Inventory and the Motivation to Protect against Covid-19 Questionnaire. Three single items furthermore explored the prevailingly sources of information for Covid-19 (social media such as Facebook; traditional media such as TV; specialistic magazines such as Le Scienze) used and a single item tested the level of mistrust in Political Institutions and mass-media and its association with protection motivation, beliefs and perceived vulnerability to Covid-19.Perceived vulnerability to Covid-19 and use of protections and perceived efficacy of protections, show positive correlations with Future Positive; beliefs on Covid-19 vaccine resulted as negatively correlated with Present Fatalistic; a positive correlation between mistrust in political institutions and Present Fatalistic has been found. Social media (such as Facebook, Instagram) and traditional mass media (such as TV) as preferred systems of information are both positively correlated with beliefs on Covid-19 vaccine, perceived vulnerability and use of protections, highlighting the role of new forms of circulation of information, but also the relevance of traditional ones for young people. Perceived vulnerability to Covid-19, perceived efficacy of protections give a positive contribution to the intention to get vaccinated; mistrust in political institutions and media on the contrary reduces the intention to take the vaccine.Results are discussed in relations to preventive interventions on the young population for the improvement of self-awareness of persistence of this virus and consequently the necessity of adopting self-protection, with special attention to vaccination. The relevance of time perspective dimensions for protection suggests to include it in the programs devoted to reduce the risk of contagion.
Perancangan Buku Fotografi Perkembangan Olahraga Skateboard di Kabupaten Malang
Authors: Abdul Aziz Muhammad , Zakiy Ramadhan Ahmad , Aditya Addin , Ayu Kusumasari Adita 
Published: July 2024

Penelitian ini bertujuan untuk merancang sebuah buku fotografi yang menggambarkan perkembangan olahraga skateboard di Kabupaten Malang, dengan fokus pada Malsel Sk8 sebagai studi kasus. Metode penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan studi kasus. Data dikumpulkan melalui observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa olahraga skateboard telah mengalami perkembangan yang signifikan di Kabupaten Malang, dengan Malsel Sk8 sebagai salah satu komunitas utama yang berperan dalam mengembangkan budaya skateboard di wilayah tersebut. Melalui buku fotografi yang dirancang, diharapkan dapat lebih memperkenalkan dan mengapresiasi perkembangan serta kontribusi Malsel Sk8 dalam memajukan olahraga skateboard di Kabupaten Malang. Kesimpulan dari penelitian ini adalah pentingnya dokumentasi visual dalam memperkuat identitas dan mempromosikan kegiatan olahraga di tingkat lokal, serta potensi besar yang dimiliki oleh komunitas skateboard dalam memengaruhi perkembangan budaya olahraga di wilayah tersebut.

This research aims to design a photography book that illustrates the development of skateboarding sports in Malang Regency, with a focus on Malsel Sk8 as a case study. The research method used was qualitative research with a case study approach. Data was collected through observation, interviews, and documentation. The results showed that skateboarding sport has experienced significant development in Malang Regency, with Malsel Sk8 as one of the main communities that play a role in developing skateboarding culture in the region. Through the photography book designed, it is hoped that it can further introduce and appreciate the development and contribution of Malsel Sk8 in advancing skateboarding sports in Malang Regency. The conclusion of this research is the importance of visual documentation in strengthening identity and promoting sports activities at the local level, as well as the great potential that skateboarding communities have in influencing the development of sports culture in the region.
Morphology and novel classification of proximal humeral fractures
Authors: Liu Jichao , Zhang Ziyan , Ding Jie , Zhang Jian , Sheng Qian , Piao Chengdong 
Published: July 2024

Background: The morphology of proximal humeral fractures (PHFs) is complex, and the fixation and selection of implants need to be guided by the fracture type and classification, which requires an accurate understanding of the fracture line. This study had three purposes. 1) Define and analyze the fracture lines and morphological features of all types PHFs by three-dimensional (3D) mapping technology. 2) Determine the osteotomy position of the biomechanical model of the PHFs according to the fracture heat map. 3) Based on the analysis of the pathological morphology and distribution of a large number of consecutive cases of PHFs, propose a novel classification of PHFs.Methods: We retrospectively collected 220 cases of PHFs and generated a 3D fracture map and heat map based on computed tomography (CT) imaging. Through analysis of the fracture morphology of the 220 PHFs, a novel classification was proposed. The primary criterion for staging was the continuity between the humeral head and the greater tuberosity and lesser tuberosity, and the secondary criterion was the relationship between the humeral head segment and the humeral shaft.Results: The fracture line was primarily found around the metaphyseal zone of region of the surgical neck, with the most extensive distribution being below the larger tuberosity and on the posterior medial side of the epiphysis. We suggest that the osteotomy gap should be immediately (approximately 5–10 mm) below the lower edge of the articular surface. The most common type of fracture was type I3 (33 cases, 15.0%), followed by type IV3 fracture (23 cases, 10.4%), and type III2 fracture (22 cases, 10.0%). Interobserver and intraobserver reliability analysis for the fracture classification revealed a k value (95% confidence interval) of 0.639 (0.57–0.71) and 0.841, P &lt; 0.01, respectively.Conclusion: In this study, the fracture line and morphological characteristics of PHFs were clarified in detail by 3D mapping technique. In addition, a new classification method was proposed by analysis of the morphological characteristics of 220 PHFs, A two-part fracture model for PHFs is also proposed.
Functional determination of site-mutations in rdxA involved in metronidazole resistance of Helicobacter pylori
Authors: Huang Jia , Li Zhiyu , Ge Fulin , Sun Chao , Deng Zixin , Yao Weiyan , He Xinyi 
Published: July 2024

BackgroundMetronidazole (MTZ) is among the first-line drugs against the human gastric pathogen Helicobacter pylori (H. pylori). MTZ is used as a prodrug that is activated by an oxygen-insensitive enzyme NADPH nitroreductase (RdxA). Loss-of-function mutations in rdxA make H. pylori MTZ resistant; however, experimental proof is lacking.MethodsWe collected 139 gastric biopsy samples from patients suspected of H. pylori infection in Shanghai, and amplified Hp-specific rdxA gene from 134 samples. All these rdxA genes were sequenced and phylogenetically compared. The effect of mutations on RdxA function was measured by expressing them in Escherichia coli DH5α by using the MTZ sensitivity test.ResultsIn total, 134 gastric biopsy samples were identified as H. pylori positive. Of the 134 samples, 74 and 6 had point mutations at the various sites or promoter region of rdxA, generating truncated and extended fused proteins, respectively. The remaining 54 were full-length with single nucleotide variation (SNV) compared with the wild-type RdxA from H. pylori, with 49 clustering with hpEastAsia, 3 with hpEurope, and 2 with hpNEAfrica. All 134 rdxA were expressed in E. coli DH5α; 22 and 112 resultant strains showed MTZ-sensitive and MTZ-resistant phenotypes, respectively. Comparative analysis of single nucleotide polymorphisms (SNPs) in the functional and inactivated RdxA revealed 14 novel mutations in RdxA, 5 of which conferred MTZ resistance: S18F, D59S, L62I, S79N, and A187V.ConclusionThe occurrence of MTZ resistance induced by site-mutation of RdxA in patients with H. pylori infection was 83.6% (112/134) in the Shanghai region. The major form of loss-of-function mutation was truncation of RdxA translation at a rate of 58/112 (51.8%). Molecular detection reliably determined the resistance of H. pylori to MTZ. Thus, the functional mutants involved in MTZ resistance facilitate clinical diagnosis and medication based on sequence analysis.
Do gender and science success moderate the effects of science learning self-efficacy on science identity?
Authors: Belova Tatyana , Islamov Artem E. , Rozhnov Artemiy A. , Zhdanov Sergei P. , Sokolova Ekaterina I. , Tsomartova Dibakhan A. 
Published: July 2024

IntroductionThis study investigates the relationship between science learning self-efficacy and science identity, examining how gender and science success moderate this relationship.MethodsUsing a quantitative approach with Partial Least Squares Structural Equation Modeling, data from high school students in Moscow, Almetyevsk, Khabarovsk cities from Russia were analyzed.ResultsThe research highlights the significant positive impact of integrative science competence, practical science application, and science communication efficacy on science identity. Interestingly, gender did not significantly influence the efficacy-identity relationship, suggesting its minimal role in this context. Conversely, science success, particularly in conjunction with science communication efficacy, played a notable role, indicating a complex interplay that could affect students’ science identity.DiscussionThese findings emphasize the need for educational strategies that bolster students’ self-efficacy in science, catering to the development of a strong science identity. Future research should explore the nuanced effects of success and communication efficacy on science identity, aiming to inform interventions that support diverse and equitable participation in science education and careers.