bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Gold‐Catalyzed Cycloisomerization of Yne‐Vinylidenecyclopropanes: A Three‐Carbon Synthon for [3 + 2] Cycloadditions.
Authors: Yuan Wei , Tang Xiangying , Wei Yin , Shi Min 
Published: August 2014

AbstractA novel cycloisomerization/rearrangement of newly synthesized yne‐vinylidenecyclopropanes (I) and (III) catalyzed by a sterically hindered gold catalyst is reported.
ChemInform Abstract: Synthesis of Polycyclic Substituted Vinylarenes via a One‐Pot Intramolecular Aryl Alkylation — N‐Tosylhydrazone Insertion Reaction.
Authors: Wu Xin‐Xing , Zhou Ping‐Xin , Wang Li‐Jing , Xu Peng‐Fei , Liang Yong‐Min 
Published: August 2014

AbstractA novel method of a Pd‐catalyzed/norbornene‐mediated intramolecular C—H activation/N‐tosylhydrazone insertion reaction is described.
ChemInform Abstract: Homogeneous Cyclocarbonylation of Alkenols with Iron Pentacarbonyl.
Authors: Babjak Matej , Markovic Martin , Kandrikova Beata , Gracza Tibor 
Published: August 2014

AbstractThe Pd‐catalyzed tandem cyclization‐oxycarbonylation of (amino)polyols with a terminal double bond runs in a chemo‐ and stereoselective manner.
ChemInform Abstract: Asymmetric Chlorination/Ring Expansion for the Synthesis of α‐Quaternary Cycloalkanones.
Authors: Yin Qin , You Shu‐Li 
Published: August 2014

AbstractA highly enantioselective chlorination/ring‐expansion of cyclobutanols and oxa‐cyclobutanols is achieved using dichlorodimethylhydantoin in the presence of N‐Boc‐L‐phenylglycine as simple catalyst.
ChemInform Abstract: MaxPHOS Ligand: PH/NH Tautomerism and Rhodium‐Catalyzed Asymmetric Hydrogenations.
Authors: Cristobal‐Lecina Edgar , Etayo Pablo , Doran Sean , Reves Marc , Martin‐Gago Pablo , Grabulosa Arnald , Costantino Andrea R. , Vidal‐Ferran Anton , Riera Antoni , Verdaguer Xavier 
Published: August 2014

AbstractThe rhodium complex containing the (S)‐MaxPhos ligand is synthesized and examined as catalyst for the asymmetric hydrogenation reaction of a variety of di‐ and trisubstituted olefins.
ChemInform Abstract: Regioselective Ruthenium‐Catalyzed Carbonylative Direct Arylation of Five‐Membered and Condensed Heterocycles.
Authors: Pospech Jola , Tlili Anis , Spannenberg Anke , Neumann Helfried , Beller Matthias 
Published: August 2014

AbstractA Ru‐catalyzed carbonylative C—H bond arylation process for the three‐component synthesis of aryl‐(hetaro)aryl ketones, such as (IV), (VI), (VIII) and (X) is developed.
ChemInform Abstract: A Bis(triazolecarboxamido) Ligand for Enantio‐ and Regioselective Molybdenum‐Catalyzed Asymmetric Allylic Alkylation Reactions.
Authors: Ozkal Erhan , Pericas Miquel A. 
Published: August 2014

AbstractA novel molybdenum catalyst containing a bis(triazolocarboxamido) ligand allows the asymmetric alkylation of allylic carbonates with dimethyl malonate with excellent regio‐ and enantioselectivities.
ChemInform Abstract: Palladium‐Catalyzed Carbonylation of Quaternary Ammonium Halides to Tertiary Amides.
Authors: Lei Yizhu , Zhang Rui , Wu Linjuan , Wu Qing , Mei Hui , Li Guangxing 
Published: August 2014

AbstractThe catalyst can be recycled and reused in six catalytic cycles without significant loss of activity.
ChemInform Abstract: Lewis Acid Catalyzed [3 + 2]‐Annulations of Donor—Acceptor Cyclopropanes and Ynamides.
Authors: Mackay William D. , Fistikci Meryem , Carris Ryan M. , Johnson Jeffrey S. 
Published: August 2014

AbstractN,N‐Dimethylaniline as well as 4‐chlorophenyl substituted cyclopropane analogues fail to react.
ChemInform Abstract: Bioinspired Intramolecular Diels—Alder Reaction: A Rapid Access to the Highly‐Strained Cyclopropane‐Fused Polycyclic Skeleton.
Authors: Zhu Shifa , Guo Zhengjiang , Huang Zhipeng , Jiang Huanfeng 
Published: August 2014

AbstractThe title Au‐catalyzed Diels‐Alder reaction results in cyclopropane‐fused polycyclic products from mixtures of cis/trans dienes and enynal.
ChemInform Abstract: Palladium(0)‐Catalyzed Cyclopropanation of Benzyl Bromides via C(sp3)—H Bond Activation.
Authors: Mao Jiangang , Zhang Shuo‐Qing , Shi Bing‐Feng , Bao Weiliang 
Published: August 2014

AbstractThe structure of product (IIIa) is confirmed by X‐ray analysis.
ChemInform Abstract: Highly Selective gem‐Difluoroallylation of Organoborons with Bromodifluoromethylated Alkenes Catalyzed by Palladium.
Authors: Min Qiao‐Qiao , Yin Zengsheng , Feng Zhang , Guo Wen‐Hao , Zhang Xingang 
Published: August 2014

AbstractThe presented method is applicable to a broad scope of organoboronic and bromo difluoro allyl compounds.
ChemInform Abstract: Enantioselective Cu‐Catalyzed Decarboxylative Propargylic Amination of Propargyl Carbamates.
Authors: Zou Yuan , Zhu Fu‐Lin , Duan Zheng‐Chao , Wang Ya‐Hui , Zhang De‐Yang , Cao Zhong , Zheng Zhuo , Hu Xiang‐Ping 
Published: August 2014

AbstractThe title reaction proceeds under mild conditions and is suitable for a broad range of substrates providing optically active propargylic amines in high yields with high enantioselectivities.
ChemInform Abstract: Catalytic Enantioselective Synthesis of α‐Arylaminocyclobutanones.
Authors: Aitken David J. , Caboni Pierluigi , Eijsberg Hendrik , Frongia Angelo , Guillot Regis , Ollivier Jean , Piras Pier Paolo , Secci Francesco 
Published: August 2014

AbstractOptimized conditions allow the enantioselective synthesis of the title compounds from racemic α‐hydroxycyclobutanone and N‐alkylaniline derivatives via a tandem condensation/keto‐enol tautomerization process.
ChemInform Abstract: A Facile Method for the Preparation of Bishomopropargylic Alcohols from Acyl Chlorides.
Authors: Vasquez Suhelen , Cabezas Jorge A. 
Published: August 2014

AbstractA propargyl dianion equivalent (prepared from propargyl bromide and nBuLi) reacts with acyl chlorides and esters via its propargyl anion position to yield bishomopropargylic alcohols after acidic work‐up.
ChemInform Abstract: Visible‐Light‐Induced C—S Bond Activation: Facile Access to 1,4‐Diketones from β‐Ketosulfones.
Authors: Xuan Jun , Feng Zhu‐Jia , Chen Jia‐Rong , Lu Liang‐Qiu , Xiao Wen‐Jing 
Published: August 2014

AbstractThe title reaction affords symmetrical and unsymmetrical 1,4‐diketones which can be easily transformed into biologically valuable compounds [cf.
ChemInform Abstract: Effects of Reaction Conditions on Quinone/Diquinone Product Ratios in the Oxidation of 1,4‐Dimethoxybenzene Derivatives with Ceric Ammonium Nitrate.
Authors: Love Brian E. , Duffy Brian C. , Simmons Alexander L. 
Published: August 2014

AbstractCAN oxidation of 1,4‐dimethoxybenzene derivatives affords quinone or diquinones depending on the solvent employed and the mode of addition.
ChemInform Abstract: Hiyama Cross‐Coupling Reaction Catalyzed by a Palladium Salt of 1‐Benzyl‐4‐aza‐1‐azoniabicyclo[2.2.2]octane Chloride under Microwave Irradiation.
Authors: Hajipour Abdol R. , Rafiee Fatemeh , Najafi Narges 
Published: August 2014

AbstractThe combination of homogeneous complex as a catalyst, high dipole of the quaternary salt and microwave irradiation increases lifetime of the catalyst, improve the yields and shorten the reaction times.
ChemInform Abstract: Nickel‐Catalyzed Csp2—Csp3 Bond Formation by Carbon—Fluorine Activation.
Authors: Sun Alex D. , Leung Kaylyn , Restivo Anita D. , LaBerge Nicole A. , Takasaki Harumi , Love Jennifer A. 
Published: August 2014

AbstractA new route to generate alkyl substituted aryl fluorides, such as (III), (V), (VIII) and (XI) through Ni‐catalyzed Negishi cross‐coupling reactions is described.
ChemInform Abstract: Synthesis of Indene Derivatives via Reactions of Vinylidenecyclopropanes with the N‐Acyliminium Cations Generated from Hydroxylactams.
Authors: Stepakov Alexander V. , Larina Anna G. , Boitsov Vitaly M. , Gurzhiy Vladislav V. , Molchanov Alexander P. , Kostikov Rafael R. 
Published: August 2014

AbstractA facile protocol for the Lewis‐acid‐mediated reaction of hydroxylactams with cyclopropane derivatives (II) to afford indene derivatives in low to moderate yields.
ChemInform Abstract: Phosphine‐Catalyzed Asymmetric Formal [4 + 2] Tandem Cyclization of Activated Dienes with Isatylidenemalononitriles: Enantioselective Synthesis of Multistereogenic Spirocyclic Oxindoles.
Authors: Hu Fang‐Le , Wei Yin , Shi Min 
Published: August 2014

AbstractThe title cyclization is accomplished via a tandem Rauhut—Currier/Michael/Rauhut—Currrier reaction sequence to give spirocyclic oxindoles in high yields along with excellent enantio‐ and diastereoselectivities.
ChemInform Abstract: Synthesis of Complex Dispirocyclopentanebisoxindoles via Cycloaddition Reactions of 4‐Dimethylamino‐1‐alkoxycarbonylmethylpyridinium Bromides with 2‐Oxoindolin‐3‐ylidene Derivatives.
Authors: Lu Li‐Juan , Fu Qin , Sun Jing , Yan Chao‐Guo 
Published: August 2014

AbstractThe presence of the dimethylamino group in the pyridinium bromides leads to the unexpected formation of compounds (VII) and (IX), whereas pyridinium bromides (II) gives the corresponding products (III) and (IV).
ChemInform Abstract: Flow Synthesis of Substituted γ‐Lactones by Consecutive Photocatalytic/Reductive Reactions.
Authors: Fagnoni Maurizio , Bonassi Filippo , Palmieri Alessandro , Protti Stefano , Ravelli Davide , Ballini Roberto 
Published: August 2014

AbstractPhotolytic addition reaction of aldehydes to activated alkenes and subsequent reduction with hydride under continuous flow reaction conditions provides multisubstituted γ‐lactones as mixtures of diastereomers.
ChemInform Abstract: Ene‐Carbonyl Reductive Coupling for the Synthesis of 3,3‐Disubstituted Phthalide, 3‐Hydroxyisoindolin‐1‐one and 3‐Hydroxyoxindole Derivatives.
Authors: Yeh Chien‐Hung , Lin Yi‐Chuen , Mannathan Subramaniyan , Hung Kevin , Cheng Chien‐Hong 
Published: August 2014

AbstractMoreover, the intramolecular reductive coupling of ene‐phthalimide (XI) proceeds highly diastereoselective.
ChemInform Abstract: Iridium(I)‐Catalyzed Direct C—H Bond Alkylation of the C‐7 Position of Indolines with Alkenes.
Authors: Pan Shiguang , Ryu Naoto , Shibata Takanori 
Published: August 2014

AbstractThe alkylation reaction relies on the use of the acetyl group on the nitrogen atom of indoline as a directing group.
ChemInform Abstract: Metal‐Free Trifluoromethylation and Arylation of Alkenes: Domino Synthesis of Oxindole Derivatives.
Authors: Shi Liangliang , Yang Xiaobo , Wang Yuyuan , Yang Haijun , Fu Hua 
Published: August 2014

AbstractTreatment of N‐alkyl‐N‐phenylacrylamides with the trifluoromethyl source (II) and iodosobenzene diacetate as the oxidant results in the formation of a wide range of oxindole derivatives.
ChemInform Abstract: Palladium‐Catalyzed Intermolecular C‐2 Alkenylation of Indoles Using Oxygen as the Oxidant.
Authors: Yan Zhao‐Lei , Chen Wen‐Liang , Gao Ya‐Ru , Mao Shuai , Zhang Yan‐Lei , Wang Yong‐Qiang 
Published: August 2014

AbstractMigration of the double bond in products (VII) as well as E/Z‐isomerization in product (IX) is confirmed by X‐ray analysis.
ChemInform Abstract: Phase‐Transfer‐Catalyzed Synthesis of Pyrroloindolines and Pyridoindolines by a Hydrogen‐Bond‐Assisted Isocyanide Cyclization Cascade.
Authors: Knipe Peter C. , Gredicak Matija , Cernijenko Artiom , Paton Robert S. , Smith Martin D. 
Published: August 2014

AbstractThe entitled cascade reaction proceeds in the presence of a quaternary ammonium catalyst and base generating functionalized products with an all‐carbon quaternary stereocenter.
ChemInform Abstract: Cyclocondensation of Trifluorolactates (I) with Isocyanates
Authors: Sokolov V. B. , Aksinenko A. Yu. , Epishina T. A. , Goreva T. V. , Martynov I. V. 
Published: August 2014

Abstractas a method for the synthesis of earlier unknown CF3‐substituted oxazolidinones (III)
ChemInform Abstract: Copper‐Catalyzed Oxidative Transformation of Secondary Alcohols to 1,5‐Disubstituted Tetrazoles.
Authors: Rokade Balaji V. , Gadde Karthik , Prabhu Kandikere Ramaiah 
Published: August 2014

AbstractA mild and convenient protocol using TmsN3 as a nitrogen source is developed for the conversion of cinnamyl and benzyl alcohols into disubstituted tetrazoles.
ChemInform Abstract: Mild Addition of Carbon Nucleophiles to Pyridine and Quinoline N‐Oxides under Different Activation Conditions.
Authors: Lecointre Bertrand , Azzouz Rabah , Bischoff Laurent 
Published: August 2014

AbstractThis reaction yields the 2‐substituted pyridines as major product, often with small amounts of the 4‐substituted pyridine formed as a by‐product.
ChemInform Abstract: An Unexpected Reaction of Pyridine with Acetyl Chloride to Give Dihydropyridine and Piperidine Derivatives.
Authors: Spanu Pietro , Mannu Alberto , Ulgheri Fausta 
Published: August 2014

AbstractThe regioselectivity of the reaction can be altered by choice of the activating agent: NaH for 1,2‐ or TMS‐O‐Tf for 1,4‐selectivity.
ChemInform Abstract: Sodium Nitrite‐Catalyzed Aerobic Oxidative Csp2—Csp3 Coupling: Direct Construction of the 4‐Aryldihydroisoquinolinone Moiety.
Authors: Su Bo , Deng Meng , Wang Qingmin 
Published: August 2014

AbstractA facile protocol using NaNO2 as the catalyst and air as the terminal oxidant enables the synthesis of the title species via direct oxidative intramolecular coupling.
ChemInform Abstract: Microwave‐Assisted and Iodine Mediated Synthesis of 5‐n‐Alkyl‐cycloalkane[d]‐pyrazolo[3,4‐b]pyridines from 5‐Aminopyrazoles and Cyclic Ketones.
Authors: Galvez Jaime , Quiroga Jairo , Insuasty Braulio , Abonia Rodrigo 
Published: August 2014

AbstractThe unexpected cyclocondensation‐aromatization reaction of 5‐aminopyrazoles with cyclic ketones provides an easy, direct, and regioselective access to the title derivatives.
ChemInform Abstract: Highly Facile and Regio‐Selective Synthesis of Pyrazolo[1,5‐a]pyrimidines via Reactions of 1,2‐Allenic Ketones with Aminopyrazoles.
Authors: Zhang Xinying , Song Yunping , Gao Lin , Guo Xiaojie , Fan Xuesen 
Published: August 2014

AbstractThe title reaction shows high regioselectivity with all the allenic ketones substrates (II), except for those bearing an alkyl group at the internal position of the allene moiety, e.g. (IV).
ChemInform Abstract: Reversible P(III)/P(V) Redox: Catalytic Aza‐Wittig Reaction for the Synthesis of 4(3H)‐Quinazolinones and the Natural Product Vasicinone.
Authors: Wang Long , Wang Ying , Chen Min , Ding Ming‐Wu 
Published: August 2014

AbstractBesides for the synthesis of the drug methaqualone (IVb) and the natural product deoxyvasicinone (Xa) the method is used as the key step in the preparation of the alkaloid (S)‐vasicinone.
ChemInform Abstract: Novel 5‐Acetyl‐3‐aryl‐2‐thioxo‐dihydropyrimidine‐4,6(1H,5H)‐diones: One Pot Three‐Component Synthesis, Characterization and Antibacterial Activity.
Authors: Saeed Aamer , Abbas Naeem , Ashraf Zaman , Bolte Michael 
Published: August 2014

AbstractThe title compounds (IV) are screened for their preliminary antibacterial activity against a panel of Gram‐positive and Gram‐negative bacteria.
ChemInform Abstract: New Palladium‐Catalyzed Domino Reaction with Intramolecular Ring Closure of an N‐(2‐Chloro‐3‐heteroaryl)arylamide: First Synthesis of Oxazolo[4,5‐b]pyrazines.
Authors: Demmer Charles S. , Hansen Jacob C. , Kehler Jan , Bunch Lennart 
Published: August 2014

AbstractOptimized reaction conditions for the Pd‐catalyzed domino reaction between 2,3‐dichloropyrazine and primary amides to form oxazolopyrazine derivatives are presented.
ChemInform Abstract: Iridium‐Catalyzed ortho‐C—H Borylation of Aromatic Aldimines Derived from Pentafluoroaniline with Bis(pinacolate)diboron.
Authors: Sasaki Ikuo , Amou Tatsunosuke , Ito Hajime , Ishiyama Tatsuo 
Published: August 2014

Abstractusing 2‐norbornene as H2 scavenger
ChemInform Abstract: Allylsilane‐Interrupted Homo‐Nazarov Cyclization and Synthesis of Bicyclo[3.2.1]octan‐8‐ones.
Authors: Yadav Veejendra K. , Naganaboina Vijaya K. , Hulikal Vijaykumar 
Published: August 2014

AbstractAllylsilanes add to oxyallyl cations, generated from homo‐Nazarov cyclization of cyclopropyl vinyl ketones to give bicyclooctan‐8‐one derivatives in exo configuration.
ChemInform Abstract: Unprecedented Control of Selectivity in Nickel‐Catalyzed Hydrophosphorylation of Alkynes: Efficient Route to Mono‐ and Bisphosphonates.
Authors: Khemchyan Levon L. , Ivanova Julia V. , Zalesskiy Sergey S. , Ananikov Valentine P. , Beletskaya Irina P. , Starikova Zoya A. 
Published: August 2014

AbstractThe hydrophosphorylation of internal alkynes (I) can be controlled by the catalyst loading to give mono‐ and bis‐phosphonates selectively.
ChemInform Abstract: Stereoselective Synthesis of Phosphoryl‐Substituted Phenols.
Authors: Xiong Biquan , Li Mei , Liu Yanxi , Zhou Yongbo , Zhao Changqiu , Goto Midori , Yin Shuang‐Feng , Han Li‐Biao 
Published: August 2014

AbstractA divergent method for the preparation of (RP)‐ and (SP)‐phosphoryl substituted phenolic compounds by using optically active (‐)‐menthyl substituted phosphorylation reagents.
ChemInform Abstract: Characterization of Eight New Secondary Metabolites from the Mutant Strain G‐444 of Tubercularia sp. TF5.
Authors: Lu Chun‐Hua , Liu Shao‐Song , Wang Jing‐Yi , Wang Ming‐Zi , Shen Yue‐Mao 
Published: August 2014

AbstractEight new metabolites, including new sesquiterpenoids (I), a new backbone sesquiterpene rearranged from guaiane, two disecoguaianes (II), two new dihydroisocoumarins (IV), and one new tetralone (III) are isolated together with ten known compounds.
ChemInform Abstract: Chemical Constituents of the Endophytic Fungus Phomopsis sp. A240 Isolated from Taxus chinensis var. mairei
Authors: Tao Mei‐Hua , Chen Yu‐Chan , Wei Xiao‐Yi , Tan Jian‐Wen , Zhang Wei‐Min 
Published: August 2014

Abstractisolation, structure, cytotoxic and antioxidant activities of the new sesquiterpene, eremophil‐9‐ene‐11,12,13‐triol (I), the new oxazole (II) and two known lactones
ChemInform Abstract: Synthesis and Biological Evaluation of Quinaldopeptin.
Authors: Katayama Katsushi , Okamura Takuya , Sunadome Takuya , Nakagawa Koji , Takeda Hiroshi , Shiro Motoo , Matsuda Akira , Ichikawa Satoshi 
Published: August 2014

AbstractThe product of this second generation total synthesis is suggested to possess cytotoxic activity against human cancer cell lines as well as HIF‐1 inhibitory activity.
ChemInform Abstract: Asymmetric Synthesis of Both Enantiomers of a δ‐Lactone Analogue of Muricatacin.
Authors: Doran Robert , Guiry Patrick J. 
Published: August 2014

Abstract(R,R)‐ and (S,S)‐6‐(1‐hydroxytridecyl)tetrahydro‐2H‐pyran‐2‐ones [compounds (‐)‐I* and (+)‐I*, resp.] are synthesized via regioselective ring‐opening addition of a Grignard reagent derived from 2‐(2‐bromoethyl)‐1,3‐dioxane to (R,R)‐ or (S,S)‐2‐(1‐benzyloxytridecyl)oxirane, resp., ZrCl4‐catalyzed deprotection and cyclization, MCPBA‐mediated oxidation of derived acetal and, finally, debenzylation.
ChemInform Abstract: Asymmetric Synthesis of Naturally Occurring Nonenolide Xyolide Through Cross Metathesis and Macrolactonization Reaction.
Authors: Rej Rohan Kalyan , Jana Anuvab , Nanda Samik 
Published: August 2014

AbstractThe asymmetric synthesis of xyolide (VI) from nonanal with an overall yield of 5% is reported.
ChemInform Abstract: Stereoselective Total Synthesis of (+)‐Hyptolide.
Authors: Sabitha Gowravaram , Raju A. , Reddy C. Nagendra , Yadav J. S. 
Published: August 2014

AbstractThe total synthesis of (+)‐(I) was completed from 3‐butyn‐1‐ol with an overall yield of 7% relying on regioselective epoxide opening, Sharpless asymmetric epoxidation, aldehyde‐alkyne coupling, and ring‐closing metathesis reactions as key steps.
ChemInform Abstract: New Isoprenylated Aurones from the Flowers of Rosa damascena
Authors: Li Yin‐Ke , Sun Ji‐Qing , Gao Xue‐Mei , Lei Chun 
Published: August 2014

Abstractisolation and structure elucidation of three new isoprenylated aurones, damaurones C—E, along with six known compounds
ChemInform Abstract: Mn3O4 Nano‐Sized Crystals: Rapid Synthesis and Extension to Preparation of Nanosized LiMn2O4 Materials.
Authors: Cui Xiao‐ling , Li Yong‐li , Li Shi‐you , Sun Guo‐cun , Ma Jin‐xia , Zhang Lu , Li Tian‐ming , Ma Rong‐bo 
Published: August 2014

AbstractNanosized Mn3O4 crystals are prepared by blowing air into a mixture of Mn(OAc)2 and NH3·H2O dissolved in EtOH (50 °C, 5 min).
ChemInform Abstract: Effect of Ion Doping on the Electrochemical Performances of LiFePO4—Li3V2 (PO4)3 Composite Cathode Materials
Authors: Jin Chao , Zhang Xudong , He Wen , Wang Yan , Li Haiming , Wang Zhuo , Bi Zhiying 
Published: August 2014

AbstractReview: 81 refs.
ChemInform Abstract: The Reactivity of 8‐Hydroxyquinoline and Its Derivatives Toward α‐Cyanocinnamonitriles and Ethyl α‐Cyanocinnamates: Synthesis, Reactions, and Applications of 4H‐Pyrano[3,2‐h]quinoline Derivatives
Authors: El‐Agrody Ahmed M. , Afifi Tarek H. 
Published: August 2014

AbstractReview: 49 refs.
Photocatalytic Generation of Hydrogen from Water under Aerobic Conditions
Authors: Staehle Robert , Losse Sebastian , Filipovic Milos R. , Ivanović‐Burmazović Ivana , Vos Johannes G. , Rau Sven 
Published: August 2014

AbstractIn this contribution, we report a detailed investigation of a photocatalytic system capable of producing hydrogen under aerobic conditions. This system consists of [Ru(dnbpy)(tbbpy)2](PF6)2 (1; dnbpy=4,4′‐dinitrile‐2,2′‐bipyridine; tbbpy=4,4′‐di‐tert‐butyl‐2,2′‐bipyridine) as the chromophore, [Co(dmgH)2] (dmgH=dimethylglyoximato) as the reduction catalyst, and triethylamine (TEA) as the electron donor. Most surprisingly, the system shows a higher catalytic activity under aerobic than under inert conditions. Detailed investigations of the catalytic process reveal that the nitrile groups probably convert to amides upon addition of TEA, and further intermediates are formed during the catalytic process. For further investigation of the surprising photocatalytic behavior of compound 1 in air, UV/Vis spectroscopic studies and time‐dependent measurements of the oxygen concentration during the photocatalytic process, both in the headspace and the liquid phase, are performed.
The spatiotemporal segregation of GAD forms defines distinct GABA signaling functions in the developing mouse olfactory system and provides novel insights into the origin and migration of GnRH neurons
Authors: Vastagh Csaba , Schwirtlich Marija , Kwakowsky Andrea , Erdélyi Ferenc , Margolis Frank L. , Yanagawa Yuchio , Katarova Zoya , Szabó Gábor 
Published: August 2014

ABSTRACTGamma‐aminobutyric acid (GABA) has a dual role as an inhibitory neurotransmitter in the adult central nervous system (CNS) and as a signaling molecule exerting largely excitatory actions during development. The rate‐limiting step of GABA synthesis is catalyzed by two glutamic acid decarboxylase isoforms GAD65 and GAD67 coexpressed in the GABAergic neurons of the CNS. Here we report that the two GADs show virtually nonoverlapping expression patterns consistent with distinct roles in the developing peripheral olfactory system. GAD65 is expressed exclusively in undifferentiated neuronal progenitors confined to the proliferative zones of the sensory vomeronasal and olfactory epithelia In contrast GAD67 is expressed in a subregion of the nonsensory epithelium/vomeronasal organ epithelium containing the putative Gonadotropin‐releasing hormone (GnRH) progenitors and GnRH neurons migrating from this region through the frontonasal mesenchyme into the basal forebrain. Only GAD67+, but not GAD65+ cells accumulate detectable GABA. We further demonstrate that GAD67 and its embryonic splice variant embryonic GAD (EGAD) concomitant with GnRH are dynamically regulated during GnRH neuronal migration in vivo and in two immortalized cell lines representing migratory (GN11) and postmigratory (GT1–7) stage GnRH neurons, respectively. Analysis of GAD65/67 single and double knock‐out embryos revealed that the two GADs play complementary (inhibitory) roles in GnRH migration ultimately modulating the speed and/or direction of GnRH migration. Our results also suggest that GAD65 and GAD67/EGAD characterized by distinct subcellular localization and kinetics have disparate functions during olfactory system development mediating proliferative and migratory responses putatively through specific subcellular GABA pools. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 75: 249–270, 2015