bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spectral Graph-Based Networks for Mooring Line Failure Detection on FPSO
Authors: De Melo Costa José Lucas , Kurike Matsumoto Fernando , Netto Caio F. Deberaldini , de Barros Marcel R. , do Nascimento Queiroz Filho Asdrubal , Gomi Edson S. , Tannuri Eduardo A. , Reali Costa Anna Helena 
Published: August 2024

Abstract
Robust monitoring is vital in offshore oil and gas exploration, especially for Floating Production, Storage, and Offloading (FPSO) platforms pivotal in subsea hydrocarbon extraction. Motivated by the glaring absence of failure detection systems in mooring lines on FPSOs, this work tackles the broader issue of inadequate monitoring and warning systems in the sector despite their pivotal role in safety. Existing approaches often overlook inter-series correlations in multivariate scenarios. The authors introduce Graph Neural Networks (GNNs), particularly Spectral-Temporal GNN (StemGNN), leveraging recent time series processing advancements to fill this gap. Operating in the spectral domain, StemGNN captures intra-series and inter-series correlations, enhancing accuracy. The innovative approach improves classifying multivariate time series, particularly the motion time series of offshore platforms for mooring line rupture detection, considering platform oscillation. This work develops, implements, and tests an alert system for potential cable breaks on offshore platforms. Beyond operational value, it contributes to technological innovation through machine learning, overcoming conventional monitoring limitations. Results show comparable performance to state-of-the-art models, highlighting the proposed model’s suitability for real-world scenarios with noisy or missing data. Its complexity addresses challenges without sacrificing performance, advancing mooring line failure detection in offshore oil and gas, guiding future research.
The plasmid-encoded members of paralogous gene family 52 are dispensable to the enzootic cycle of
Borrelia burgdorferi
Authors: Groshong Ashley M. , Gibbons Nora E. , Moore Brendan P. , Bellamy William T. , Blevins Jon S. 
Published: August 2024

ABSTRACT

Lyme disease, the leading vector-borne disease in the United States and Europe, develops after infection with
Borrelia burgdorferi sensu lato
bacteria. Transmission of the spirochete from the tick vector to a vertebrate host requires global changes in gene expression that are controlled, in part, by the Rrp2/RpoN/RpoS alternative sigma factor cascade. Transcriptional studies defining the
B. burgdorferi
RpoS regulon have suggested that RpoS activates the transcription of paralogous family 52 (PFam52) genes. In strain B31, PFam52 genes (
bbi42
,
bbk53
, and
bbq03
) encode a set of conserved hypothetical proteins with >89% amino acid identity that are predicted to be surface-localized. Extensive homology among members of paralogous families complicates studies of protein contributions to pathogenicity as the potential for functional redundancy will obfuscate findings. Using a sequential mutagenesis approach, we generated clones expressing a single PFam52 paralog, as well as a strain deficient in all three. The single paralog expressing strains were used to confirm BBI42, BBK53, and BBQ03 surface localization and RpoS regulation. Surprisingly, the PFam52-deficient strain was able to infect mice and complete the enzootic cycle similar to the wild-type parental strain. Indeed, the presence of numerous pseudogenes that contain frameshifts or internal stop codons among the PFam52 genes suggests that they may be subjected to gene loss in
B. burgdorferi
’s reduced genome. Alternatively, the lack of phenotype might reflect the limitations of the experimental mouse infection model.
Draft genome sequence of cellulose-degrading
Bacillus stercoris
BHUJPV-SS7 isolated from soil mixed with wood powder
Authors: Singh Saurabh , Pereira Arthur Prudêncio de Araujo , Pellegrinetti Thierry A. , Verma Jay Prakash 
Published: August 2024

ABSTRACT

We report a complete genome of
Bacillus stercoris
BHUJPV-SS7 isolated from soil which contains 4,299 predicted genes and 4,012 predicted protein-coding genes within its chromosome (4,115,399 bp), and has 43.51% G + C content and a predicted beta-1,4-glucanase (EC 3.2.1.4) gene.
Subsequent musculoskeletal injury after concussion in National Football League players
Authors: Wasserman Erin B , Chretien Alexandra , Harmon Kimberly G , Putukian Margot , Okonkwo David , Solomon Gary S , Cardenas Javier , Herzog Mackenzie M , Sills Allen , Mack Christina D 
Published: August 2024

ObjectiveTo assess whether National Football League (NFL) players diagnosed with a concussion have an increased risk of injury after return to football.MethodsA retrospective cohort study analysed the hazard of subsequent time-loss lower extremity (LEX) or any musculoskeletal injury among NFL players diagnosed with a concussion in 2015–2021 preseason or regular season games compared with: (1) all non-concussed players participating in the same game and (2) players with time-loss upper extremity injury. Cox proportional hazards models were adjusted for number of injuries and concussions in the prior year, player tenure and roster position. Additional models accounted for time lost from participation after concussion.ResultsThere was no statistical difference in the hazards of LEX injury or any musculoskeletal injury among concussed players compared with non-concussed players, though concussed players had a slightly elevated hazard of injury (LEX injury: HR=1.12, 95% CI 0.90 to 1.41; any musculoskeletal injury: HR=1.08, 95% CI: 0.89 to 1.31). When comparing to players with upper extremity injuries, the hazard of injury for concussed players was not statistically different, though HRs suggested a lower injury risk among concussed players (LEX injury: HR=0.78, 95% CI: 0.60 to 1.02; any musculoskeletal injury: HR=0.82, 95% CI: 0.65 to 1.04).ConclusionWe found no statistical difference in the risk of subsequent injury among NFL players returning from concussion compared with non-concussed players in the same game or players returning from upper extremity injury. These results suggest deconditioning or other factors associated with lost participation time may explain subsequent injury risk in concussed players observed in some settings after return to play.
Real-world study of the multimorbidity and health service utilisation among individuals with non-diabetic hyperglycemia and type 2 diabetes mellitus in North West London
Authors: Dattani Rakesh , Ul-Haq Zia , Shah Moulesh , Kamalati Tahereh , Pierce Benjamin , Lucas Amanda , Baruwa Ahmed , Bickford-Smith Livi , Chilcott Jack , Griffiths Thomas , Frankel Andrew Howard , Willis Tony , Tam Frederick Wai Keung 
Published: August 2024

IntroductionThe prevalence of non-diabetic hyperglycemia (NDH) and type 2 diabetes mellitus (T2DM) is increasing. While T2DM is recognised to be associated with multimorbidity and early mortality, people with NDH are frequently thought to be devoid of such complications, potentially exposing individuals with NDH to suboptimal care. We therefore used the Discover London Secure Data Environment (SDE) dataset to appreciate the relationship of NDH/T2DM with multimorbidity, healthcare usage, and clinical outcomes.Research design and methodsThe dataset was retrospectively analysed between January 1, 2015 and December 31, 2020 to understand the relationship between NDH/T2DM and multimorbidity primary/secondary healthcare usage and clinical outcomes. This was compared with a cohort of individuals with thyroid disease but no NDH/T2DM.ResultsThe dataset identified 152,384 and 124,190 adults with NDH and T2DM compared with 11,626 individuals with thyroid disease (control group). Individuals with NDH and individuals with T2DM had a high burden of disease, with only 13.1% of individuals with either NDH or T2DM not found to be suffering from at least one of the disease states of interest. The three most common comorbidities experienced by individuals with NDH were hypertension (41.4%), hypercholesterolemia (37.5%), and obesity (29.8%) compared with retinopathy (68.7%), hypertension (59.4%), and obesity (45.8%) in individuals with T2DM. Comparatively, the most common comorbidities in the control group were depression (30.8%), hypercholesterolemia (24.4%), and hypertension (17.1%). 28 (control group), 12 (NDH), and 16 (T2DM) primary care contacts per individual per year were identified, with 27,881, 282,371, and 314,880 inpatient admissions for the control, NDH, and T2DM cohorts, respectively. Prescription of drugs used to treat T2DM in individuals with NDH and T2DM was 27,772 (18.2%) and 109,361 (88.1%), respectively, accounting for approximately one in five individuals with NDH developing T2DM.ConclusionBoth NDH and T2DM were associated with significant multimorbidity alongside primary and secondary care utilisation. Given the morbidity highlighted with NDH, we highlight the need for earlier detection of NDH, recognition of multimorbidity associated with both NDH and T2DM, as well as the need for the further implementation of interventions to prevent progression to T2DM/multimorbidity.
Guidelines and regulations applicable to vitro diagnostic tests in the UK: a scoping review
Authors: Staworko Magdalena , Khawar Oscar , Sullivan Frank , Donnelly Peter D , Deeks Jon , McCartney Margaret 
Published: August 2024

ObjectiveTo describe recommendations applicable to new diagnostic and screening tests brought to market in the UK as of 01 June 2023; and extract agreements, disagreements and gaps.DesignExtant regulations, recommendations and guidelines for new diagnostic and screening tests applicable to new products placed in the UK market as of 01 June 2023. Non-English and references not applicable to new tests seeking market access in the UK on 01 June 2023 were excluded.Data sourcesPubMed, Web of Science Core Collection and Scopus; grey literature via EuropePMC and Google, government regulations and guidelines, and relevant professional societies. References of relevant included data were scanned for includable articles. Resultant data were thematically analysed and presented as a narrative scoping review.Eligibility for selecting studiesPubMed, Web of Science Core Collection and Scopus were searched from 1/1/2018 for regulations, guidelines or recommendations for in vitro diagnositic tests as applied to the UK on 1/6/23. Relevant papers also had references searched.Results943 items were initially identified with 892 excluded. Reference searching located a further 31 papers and 82 items were analysed. Seven themes were identified: regulation, companion diagnostics and lab developed tests, safety and evidence, test specific recommendations, data, innovation and recommendations for patients/the public. Wide agreement included the need to reduce bureaucracy and duplication; to mitigate to avoid unintended consequences of In Vitro Diagnostic Regulation. Disagreement over whether high-quality evidence should precede regulatory approval, or could be gathered as part of postmarketing surveillance emerged.ConclusionsIndustry, regulators, academics, patients representing a variety of views, should collaborate to work through areas of disagreement.
Association of pre-existing cardiovascular disease with administration of fluoropyrimidine chemotherapy in patients with gastrointestinal malignancies
Authors: Abiodun Aderonke Temilade , Ju Chengsheng , Welch Catherine A , Lai Jennifer , Tyrer Freya , Chambers Pinkie , Paley Lizz , Vernon Sally , Deanfield John , de Belder Mark , Rutherford Mark , Lambert Paul C , Slater Sarah , Shiu Kai Keen , Wei Li , Peake Michael D ,   The VICORI collaborative, Adlam David , Manisty Charlotte 
Published: August 2024

ObjectiveFluoropyrimidine chemotherapy is a first-line treatment for many gastrointestinal (GI) cancers, however, cardiotoxicity concerns may limit administration in patients with pre-existing cardiovascular disease (CVD). This study investigated the association of pre-existing CVD with use of fluoropyrimidine chemotherapy in tumour-eligible GI cancer patients.Methods and analysisNational cancer registry data from the Virtual Cardio-Oncology Research Initiative from England between 2014 and 2018 was used to identify GI cancer patients eligible to receive fluoropyrimidine chemotherapy. Linkage to Hospital Episode Statistics and CVD registry data were used to ascertain prior CVD and outcomes. Primary outcome was first administration of fluoropyrimidine chemotherapy following cancer diagnosis. Cox proportional hazard models determined HR and 95% CIs for the association between initiation of fluoropyrimidine treatment and prior CVD.Results112 726 eligible patients were identified (median age 71 years (IQR 62–80), 39.7% female). 33 026 (29.3%) had pre-existing CVD. 73 392 (65.1%) patients had a diagnosis of colorectal, 23 208 (20.6%) oesophageal, 14 788 (13.1%) gastric and 1338 (1.2%) small bowel cancer. Individuals with pre-existing CVD had a 27% reduced rate of receiving fluoropyrimidine chemotherapy (HR, 0.73; 95% CI 0.70 to 0.75) on multivariable analysis. Significantly reduced rates of fluoropyrimidine administration were found across all subtypes of pre-existing CVD.ConclusionsGI cancer patients with all types of pre-existing CVD are less likely to receive fluoropyrimidine chemotherapy despite eligibility. This suggests widespread caution regarding administration of fluoropyrimidines across this population; further research is needed to assess whether such conservatism is justified.
Environmental impact of single-use versus reusable gastroscopes
Authors: Pioche Mathieu , Pohl Heiko , Cunha Neves João A , Laporte Arthur , Mochet Mikael , Rivory Jérôme , Grau Raphaelle , Jacques Jérémie , Grinberg Daniel , Boube Mathilde , Baddeley Robin , Cottinet Pierre-Jean , Schaefer Marion , Rodríguez de Santiago Enrique , Berger Arthur 
Published: August 2024

Abstract

Introduction
The environmental impact of endoscopy is a topic of growing interest. This study aimed to compare the carbon footprint of performing an esogastroduodenoscopy (EGD) with a reusable (RU) or with a single-use (SU) disposable gastroscope.

Methods

SU (Ambu aScope Gastro) and RU gastroscopes (Olympus, H190) were evaluated using life cycle assessment methodology (ISO 14040) including the manufacture, distribution, usage, reprocessing and disposal of the endoscope. Data were obtained from Edouard Herriot Hospital (Lyon, France) from April 2023 to February 2024. Primary outcome was the carbon footprint (measured in Kg CO
2
equivalent) for both gastroscopes per examination. Secondary outcomes included other environmental impacts. A sensitivity analysis was performed to examine the impact of varying scenarios.

Results

Carbon footprint of SU and RU gastroscopes were 10.9 kg CO
2
eq and 4.7 kg CO
2
eq, respectively. The difference in carbon footprint equals one conventional car drive of 28 km or 6 days of CO
2
emission of an average European household. Based on environmentally-extended input-output life cycle assessment, the estimated per-use carbon footprint of the endoscope stack and washer was 0.18 kg CO
2
eq in SU strategy versus 0.56 kg CO
2
eq in RU strategy. According to secondary outcomes, fossil eq depletion was 130 MJ (SU) and 60.9 MJ (RU) and water depletion for 6.2 m
3
(SU) and 9.5 m
3
(RU), respectively.

Conclusion
For one examination, SU gastroscope have a 2.5 times higher carbon footprint than RU ones. These data will help with the logistics and planning of an endoscopic service in relation to other economic and environmental factors.
Australian parental decisions about transitioning children from booster seats in a randomised trial: greater support may be needed
Authors: Powell Stacie , Dai Wennie , Ho Catherine , Albanese Bianca , Keay Lisa , Whyte Tom , Bilston Lynne E , Brown Julie 
Published: August 2024

BackgroundPremature graduation to an adult seatbelt is common and detrimental to optimal crash protection. While there is an existing tool (the5-step test) to support a parent’s decision to graduate their child, its effectiveness is unknown. The aim of this study was to evaluate the5-step test.MethodA randomised controlled design was used. Participants were parents of children aged 7–12 years. After exposure to information about the5-step testor control material, participants assessed belt fit in three seating conditions and ‘thought aloud’ while making their assessment. Seating conditions provided a good, poor and partially good seatbelt fit based on the child’s anthropometry. Participants were also assessed on their knowledge of good seatbelt fit criteria.ResultsParticipants exposed to the5-step test(n=18) had significantly improved their knowledge of the criteria required to achieve good seatbelt with, on average, 1.0 higher score in the 6-point assessment (95% CI 0.23 to 1.7, p=0.012) than those in the control group. There was also a greater percentage of participants in this group (44.4% intervention vs 27.8% control) who made accurate decisions about seatbelt fit, but this difference did not reach significance (OR 2.08, 95% CI 0.52 to 8.34).ConclusionThe results demonstrate that the5-step testis effective in improving knowledge but are inconclusive about its effectiveness in promoting accurate decision-making. However, the proportion of participants making accurate decisions in the intervention group remained low. This suggests that parents may require greater assistance than what is currently provided.
Bridging thrombolysis before endovascular therapy is associated with better outcomes in patients with large infarction core
Authors: Guo Yu , Xu Yong-Gang , Liu Chao , Zhang Heng-Zhu , Luo Wenmiao 
Published: August 2024

BackgroundThis study investigates the efficacy and safety of bridging intravenous thrombolysis (IVT) before endovascular therapy (EVT) compared with EVT alone in patients with large infarction core.MethodsWe conducted a comprehensive search of PubMed, EMBASE, and the Cochrane Library from January 2015 to June 2024. Included studies involved patients with acute ischemic stroke with an Alberta Stroke Program Early CT Score of ≤5 or an ischemic core volume of ≥50 mL. Studies were required to provide either 90-day modified Rankin Scale (mRS) score, reperfusion, symptomatic intracranial hemorrhage (sICH), or 90-day mortality.ResultsNine observational studies with 2641 patients were analyzed. The IVT+EVT group had a higher rate of 90-day functional independence (mRS 0–2; OR 1.56, 95% CI 1.31 to 1.87; adjusted OR (aOR) 1.43, 95% CI 1.21 to 1.68) and 90-day functional outcome (mRS 0–3; OR 1.34, 95% CI 1.11 to 1.62; aOR 1.18, 95% CI 1.02 to 1.37) compared with EVT alone. There was no significant difference in successful reperfusion (OR 1.01, 95% CI 0.62 to 1.64; aOR 1.07, 95% CI 0.74 to 1.54) and 90-day mortality (OR 0.86, 95% CI 0.73 to 1.02; aOR 0.89, 95% CI 0.77 to 1.04) between the two groups. Moreover, patients who received IVT+EVT had a higher rate of sICH (OR 1.30, 95% CI 1.03 to 1.64; aOR 2.21, 95% CI 1.22 to 4.01).ConclusionsIn patients with large infarction core, bridging IVT before EVT is associated with favorable functional outcomes compared with EVT, even though bridging therapy entails a higher risk of sICH. Further trials are needed to confirm these findings.
Neck apposition is a key factor for aneurysm occlusion after Woven EndoBridge device embolization
Authors: Cortese Jonathan , Juhasz Julia , Rodriguez-Erazú Fernanda , Ghozy Sherief , Bayraktar Esref Alperen , Mihalea Cristian , Zarrintan Armin , Ueki Yasuhito , Caroff Jildaz , Kallmes David F , Spelle Laurent , Kadirvel Ramanathan 
Published: August 2024

BackgroundSealing of the aneurysm neck with a Woven EndoBridge (WEB) device is recommended for disrupting the blood flow inside the aneurysm. This study investigates the relationship between WEB neck apposition and aneurysm occlusion rates.MethodsAneurysms treated with a WEB from March 2017 to May 2022 at a single center were included. WEB neck apposition (poor/good) and WEB protrusion (yes/no) were evaluated on post-detachment high resolution cone beam CT images. Angiographic occlusion was assessed with the Bicêtre Occlusion Scale score (BOSS). Univariate and multivariable analysis tested the association between neck apposition and occlusion rates.ResultsThe study included 159 aneurysms in 141 patients (mean age 55.8±11.2 years; 64.2% women). Good neck apposition and protrusion were noted in 123 (77.4%) and 30 (18.9%) cases, respectively. Inter-rater agreements were good for neck apposition (κ=0.75) and protrusion (κ=0.78). Complete and adequate occlusion was achieved in 104 (65%) and 130 (82%) cases, respectively (median follow-up 18 months). Good neck apposition was a strong independent predictor for both adequate (adjusted OR (aOR)=5.9, 95% CI 2.4 to 14.9; P<0.001) and complete occlusion (aOR=7.1, 95% CI 3.0 to 18.1; P<0.001). Protrusion was more frequent in the adequate occlusion group versus the aneurysm recurrence group without reaching statistical significance (P=0.06), but was associated with more thromboembolic complications (9/30 (30%) vs 12/129 (9%); P<0.01). WEB shape modification was significantly greater in poor apposition cases (P=0.03).ConclusionsAchieving good neck apposition of the WEB strongly predicts aneurysm occlusion during follow-up. WEB protrusion should be minimized due to the increase in thromboembolic risk with limited impact on aneurysm occlusion.
From othering to belonging: a framework for DEI history-telling and strategising
Authors: Edwell April , Edwell Jennifer 
Published: August 2024

The medical profession in the USA is—and has long been—a segregated workforce. Currently, just 5.0% of all US physicians are black. Understanding the origins and mechanisms of this disparity is essential to creating a future where black healing and healers are supported by our medical system. In pursuit of this future, this article offers ‘othering’ and ‘belonging’ as frames of analysis and intervention for diversity and equity initiatives.Building on previous historical studies of racism in medicine, this project reveals how the figure of the ‘American physician’ was created through exclusionary/othering tactics. In part 1, we analyse antebellum historical sources to demonstrate the role of medicine in creating and promulgating racial categories and hierarchies. Next, in part 2, we explore the historical conditions that produced the American physician as a significant professional identity by analysing texts by the American Medical Association and affiliated state medical societies. Then, we turn towards solutions in part 3. To redress inequities produced by othering, particularly the continued exclusion of black people from the medical profession, we argue that medical leaders should cultivate a professional culture of belonging. As we will explain, belonging goes beyond tolerating and respecting difference; it entails shared culture, equal rights and inclusive structures.