bluuebunny/crossref_metadata_2025_split huggingface dataset:
Landscape and Pleistocene refuges played a major role in shaping the population structure of endemic Atlantic Forest spiny rats Trinomys dimidiatus and Trinomys iheringi (Echymidae)
Authors: Oliveira Marcelo de Assis Passos , Vilasboa Anderson , Oliveira Marcione Brito , Bonvicino Cibele Rodrigues 
Published: August 2024

Abstract

The Atlantic Forest has experienced a significant loss of its original vegetation, with more than 80% of the biome now comprising small and isolated fragments. To understand species distribution, it is crucial to comprehend the impact of fragmentation on species persistence within this biome. Previous phylogeographic inferences have indicated that Trinomys iheringi and T. dimidiatus are structured into two populations. In this study, we employed a more comprehensive database to re-examine the phylogeography and conduct a detailed analysis of the demographic history and population structure of two Trinomys species. The results indicate that T. dimidiatus is structured into at least three populations: Serra dos Órgãos, South Center of Serra do Mar, and North of Serra do Mar. In contrast, T. iheringi is highly structured into two populations: São Paulo and Ilha Grande. The demographic analysis indicated T. dimidiatus from Serra do Mar exhibited an expansionary trend during periods of reduced sea level with an optimal area reduction during LGM. In the past, T. iheringi presented the expansion of suitable areas onto the emerging continental shelf during the Last Glacial Maximum (LGM) but it did not impact the population's structure. The results suggest that retreat forest events during the Pleistocene and landscape factors were instrumental in shaping the population structure of the Trinomys species. Additionally, T. iheringi represents an entirely isolated island population exhibiting no gene flow, and analysis suggests the presence of a new microendemic species.
Fault Tracing on Transformer Substations via Graph Kernel on Event Graphs
Authors: Yao Weizhuo , Yang Genke , Chu Jian 
Published: August 2024

Abstract

This paper targets fault tracing of transformer substation devices. Traditional AI-inspired methods have the potential to save vast amount of manpower. But there are two challenges they face: inadequate representation of connection topology of substation devices and the lack of interpretability of the fault tracing process, both of which are highly valued in industrial practices. Thus, this paper constructs a framework to address the problem of fault tracing by preforming graph kernel computations on specially designed event graphs. In addition, we propose an Edge-Labeled Weisfeiler Lehman Graph Kernel (EL-WL), integrating edge information into tree distance calculation of the graph kernel. Besides, we use a variant of unique class association rule mining algorithm performed on subtree histogram vectors to mine interpretable fault tracing rules. Experiment results showed noticeable performance improvement on real-world data.
Association between cardiometabolic phenotypes with atherogenic index of plasma: a cross-sectional study from the Azar Cohort Study
Authors: Soheilifard Shirin , Mahdavi Reza , Faramarzi Elnaz 
Published: August 2024

Abstract

Background: This study was conducted to determine the relationship between cardiometabolic phenotypes and atherogenic index of plasma in the Azar cohort population.
Methods: This cross-sectional study included 9,515 participants aged 35 to 55, using data from the Azar Cohort Study. Metabolic syndrome was defined based on ATP III criteria. Participants were then classified into four cardiometabolic phenotypes by considering BMI and metabolic syndrome components: metabolically healthy normal weight (MHNW, BMI <25 kg/m²), metabolically unhealthy normal weight (MUHNW, BMI <25 kg/m²), metabolically healthy obese (MHO, BMI ≥25 kg/m²), and metabolically unhealthy obese (MUHO, BMI ≥25 kg/m²). AIP was calculated.
Result: Among the subjects, 4,801 (50.5%) were metabolically healthy obese (MHO) and 2,680 (28.2%) were metabolically unhealthy obese (MUHO). High-risk AIP levels (>0.21) differed significantly across cardiometabolic phenotypes, with MUHNW (79.6%) and MUHO (64.6%) showing the highest proportions compared to MHNW (13.5%) and MHO (18.6%). After adjusting for confounders, multinomial logistic regression analysis showed individuals in the third tertile of AIP were 103.46 times more likely to be MUHNW (OR = 103.46, 95% CI: 52.82–202.64), 55.77 times more likely to be MUHO (OR = 55.77, 95% CI: 45.65–68.12), and 2.22 times more likely to be MHO (OR = 2.22, 95% CI: 1.91–2.64) compared to the MHNW phenotype (p < 0.001 for all).
Conclusion: The study demonstrates significant variation in high-risk AIP levels across cardiometabolic phenotypes, emphasizing the need for detailed metabolic health assessments beyond BMI to predict cardiovascular risk better.
Causal association between frailty and chronic obstructive pulmonary disease: insights from bidirectional Mendelian randomization and mediation analysis
Authors: Cheng Zewen , Wu Jian , Xu Chun , Yan Xiaokun 
Published: August 2024

Abstract

Background Observational studies have underscored a robust association between frailty and chronic obstructive pulmonary disease (COPD), yet the causality remains equivocal.Methods This study employed bidirectional two-sample Mendelian randomization (MR) analysis. Individuals of European ancestry with frailty and COPD were selected for analysis under the genome-wide significance threshold (P < 5×10–8). Univariable MR investigated the causal relationship between frailty and COPD. Genetic correlation was assessed using linkage disequilibrium score (LDSC) regression, while multivariable MR and mediation analysis explored the influence of various confounders and their mediating effects. The primary analytic approach was inverse variance weighted (IVW), supported by comprehensive sensitivity analyses.Results LDSC analysis revealed moderate genetic correlations between frailty and Global Biobank Meta-Analysis Initiative (GBMI) COPD (rg = 0.643, P = 6.66 × 10 − 62) as well as FinnGen COPD (rg = 0.457, P = 8.20 × 10 − 28). IVW analysis demonstrated that frailty was associated with increased risk of COPD in both the GBMI cohort (OR, 1.784; 95% CI, 1.475 to 2.158; P = 2.40 × 10 − 9) and the FinnGen database (OR, 1.854; 95% CI, 1.411 to 2.434; P = 9.02 × 10 − 6). Concurrently, COPD was identified as a susceptibility factor for frailty (GBMI: β, 0.104; 95% CI, 0.058 to 0.151; P = 1.25 × 10 − 5; FinnGen: β, 0.050; 95% CI, 0.020 to 0.079; P = 9.22 × 10 − 4). These consistent findings persisted after adjustment for potential confounders such as body mass index, age of smoking initiation, smoking initiation and sarcopenia-related traits in multivariable analyses. Additionally, mediation analysis revealed that walking pace mediated 19.11% (95% CI, 7.17–31.05%) and 15.40% (95% CI, 2.82–27.98%) of the impact of frailty on COPD risk, and 17.58% (95% CI, 2.63–32.53%) and 23.26% (95% CI, 0.97–45.55%) of the effect of COPD on frailty risk in the GBMI and FinnGen cohorts, respectively.Conclusions This study has strengthened the current evidence affirming a reciprocal causal relationship between frailty and COPD, highlighting walking pace as a pivotal mediator. Future larger-scale research is warranted to ascertain the applicability of these findings across diverse ancestries.
Evaluating Higher Education Teaching Dimensions through Student Feedback: An Exploratory Factor Analysis
Authors: Dinamling Shayne Klarisse E. , Depaynos Jonas L. 
Published: August 2024

Abstract

Considering the dynamism of learning, diversity of learners, and ambiguous criteria for effective teaching, the validity of Student Evaluation of Teaching (SET) as a measure of effectiveness and high-stakes decisions concerning faculty members is being challenged. This exploratory-descriptive study investigates the latent dimensions of teaching quality in higher education as perceived by students. Conducted at the University of the Cordilleras, Philippines, it employs exploratory factor analysis of 276 teacher education student feedback to identify crucial teaching dimensions. The 30-item survey tool, modeled after the university’s SET instrument, used a 6-point Likert scale from 1 (Poor) to 6 (Excellent) in evaluating descriptive statements of teaching practices. The analysis revealed three significant factors: resource optimization and learning support, ethical conduct and emotional intelligence, and innovative pedagogy and critical engagement. This research contributes to the discourse on improving teaching quality by providing evidence-based insights into the aspects of teaching most valued by students.
Evaluation of 5G-based closed-loop Control on Part Quality for Milling Processes
Authors: Mertes Jan , Schmitz Marius , Lindenschmitt Daniel , Schellenberger Christian , Klar Matthias , Ravani Bahram , Schotten Hans D. , Aurich Jan C. 
Published: August 2024

Abstract

Implementing wireless communication technologies in manufacturing systems shows the potential for a disruptive shift towards wireless networked control systems and edge computing for machine tool control. Especially 5G mobile communications enable wireless closed-loop control withultra-reliable low-latency communication (uRLLC) and time-sensitive networking (TSN)-features. However, currently available hardware and software cannot yet meet the high requirements for closed-loop control of machine tools.
This study evaluates the quality of a manufactured part when produced on a wireless closed-loop machine tool. A setup for emulating network characteristics (latency, jitter) is developed and implemented into a computerized numerical control (CNC) of a machine tool to synthesize the effects of 5G connectivity. The main objective is to evaluate how different network performance characteristics in combination with machine parameters influence surface quality parameters and geometric dimensioning and tolerancing (GD&T) of a milled specimen. Full factorial experimental design paradigm is used in the evaluation.
The results show that latency and feed rate have no or insignificant influence on the surface quality of the manufactured part while jitter does have a significant influence on the surface quality parameters. GD&T are just influenced by the variation of the feed rate, independent of latency and jitter. Thus, this is not directly connected to the wireless networked control system. While processes with lower control requirements (e.g. robot control, control of automated guided vehicles, etc.) can already be implemented in a wireless setting, control of machine tools to achieve high quality manufactured parts, will therefore only be possible with future developments in wireless communication.
The role of magnetic resonance imaging in evaluating migraine and the relationship between Corona and migraine cases
Authors: khattab Khalid , Alissa Fatima 
Published: August 2024

Abstract

Introduction: Magnetic resonance imaging is indicated in case of suspected posterior fossa lesions or cerebrospinal fluid leakage. This study aims to study the symptoms and radiological signs of migraine on MRI.
Methods and materials: A retrospective study was conducted on a group of patients visiting Al-Mouwasat Hospital with a history of headache in the period from 2021 to 2024. All patients underwent MRI as an investigation due to suspicion of migraine, totaling 1561 patients.
Results: The location of the headache was found to be the frontal lobe 83%, the temporal lobe 32%, around the orbits 42%, the parietal lobe 20%, the occipital lobe 14%, and the cervical lobe 17%. Speaking about the continuation of migraine attacks for days, we found that the percentage of those who have daily migraines is 13%, those who have more than 4 months 18%, 4–8 months 26%, and 4–7 months 27%. Speaking about the cases in which radiological investigation is indicated, we found that the percentage of patients who have continued and prolonged the prodromal stage is 15%, the percentage of patients who have prolonged and severe clinical symptoms is 20%, the percentage of those who have the first appearance of migraine symptoms is 15%, the percentage of migraine without prodromes that required radiological investigation is 27%, the percentage of those who have migraine with loss of consciousness is 8%, the percentage of those who have complications is 5%, and those who have prodromes without Headache 10%, and speaking of the signs observed by MRI in migraine patients, we found that high-signal foci in the second time and the FLIR time were observed at a high rate of 92%.
Conclusion: MRI is a suitable radiological method for evaluating migraine and can be used as an indicator for treatment and monitoring chronic cases.
Bioactive Peptides from Marine Organisms
Authors: Wang Peixin , Zhang Yi , Hu Jiamiao , Tan Bee Kang 
Published: August 2024

:
Marine organisms represent promising bioactive peptide resources with diverse biological
activities such as antioxidant, antimicrobial, antihypertensive, anti-fatigue, and immunoregulatory
activities. Despite many studies on marine bioactive peptides, there is a dearth of comprehensive
review articles on the emerging trends that encompass the production techniques and the biological
applications of marine bioactive peptides. In this review, we summarize the major research
and findings related to marine bioactive peptides, encompassing aspects of their production, purification,
biological activities, nanotechnology-based strategies, and their potential applications. Enzymatic
hydrolysis currently stands out as the most commonly used method for producing marine
bioactive peptides; the downstream purification process often includes a combination of multiple
purification techniques. Due to their diverse biological properties, marine peptides have garnered
considerable interest for industrial applications as active ingredients in the food, pharmaceutical,
and cosmetics industries. Additionally, the incorporation of encapsulation strategies such as nano
emulsion, nanoliposome, and microemulsions holds promise for significantly enhancing the bioavailability
and bioactivity of marine peptides. Future research should also prioritize the systematic
identification and validation of the potential health benefits of marine peptides by both in vitro
and in vivo animal models, along with the conduct of human clinical trials.
Quality by Design-Steered Development of Stealth Liposomal Formulation of Everolimus: A Systematic Optimization and Evaluation
Authors: Kaur Simranjeet , Singh Rajveer , Singh Dilpreet 
Published: August 2024

Background:
Everolimus is a drug approved for the treatment of breast cancer with HR+ and advanced
breast cancer reoccurring in postmenopausal women. The oral administration of EVE has been observed
to have low oral bioavailability and severe epithelial cutaneous events that include rashes and lip ulceration
followed by mouth ulceration after oral administration.

Aim:
The present research aimed to enhance the bioavailability by loading the EVE into a stealth liposomal
formulation (S-EVE-LIPO) intended for intravenous administration.

Methods:
The surface of the liposomes was modified with vitamin E TPGS, which prolongs the systemic
circulation of the drug and provides additional benefits like inhibition of the P-gp efflux pump and acting
synergistically with EVE.

Results:
The formulation was prepared using the thin film hydration method and optimized using a D-optimal
mixture design. ANOVA suggested the significance of the proposed mathematic model, and the optimized
formulation was generated by design expert software. The optimized formulation (S-EVE-LIPO) was observed
with nanometric size (99.5 ± 3.70 nm) with higher encapsulation efficacy (81.5 ± 2.86 %). The S-EVELIPO
formulation indicated a sustained release profile as 90.22% drug release was observed in 48 h, whereas
the formulation without vitamin E TPGS (EVE-LIPO) released only 74.15 drugs in 24 hours. In vitro cytotoxicity
study suggested that the presence of vitamin E TPGS lowers the IC50 value (54.2 ± 1.69), increases
the cellular uptake of the formulation, also increases the generation of ROS, and shows better hemocompatibility.

Conclusion:
Vitamin E TPGS could be set as a vital additive to improve therapeutic efficacy and reduce offsite
toxicity and dosing frequency.
Green Synthesis of Silver Nanoparticle Using Parmotrema parmutatum Extract and its Application in Colorimetric Sensing and Photolytic Degradation of Organic Dye
Authors: Mijar Krishna , Sapkota Asmita , Shrestha Prabina , Nyaupane Hari , Sharma Nirmala , Adhikari Achyut 
Published: August 2024

Background:
Silver nanoparticles possess distinctive characteristics, including chemical
stability, high thermal and electrical conductivity, and linear optical properties, making them unique
and fascinating. The rise of green synthesis methods for silver nanoparticles is garnering significant
interest among researchers, surpassing traditional chemical and physical approaches due to the environmentally
friendly, cost-effective, and convenient nature of synthesis. This approach stands as a
viable alternative across various sectors, encompassing research, industry, and environmental safety
initiatives.

Method:
Parmotrema permutatum was utilized in the synthesis of silver nanoparticles, followed by
their characterization using ultraviolet-visible spectroscopy, Fourier-transformed infrared spectroscopy,
X-ray diffraction, energy dispersive X-ray analysis, and scanning electron microscopy. These
nanoparticles are subsequiently employed for detecting methylene blue, formaldehyde, and hazardous
mercury metal ions as well as photocatalytically degrading methylene blue.

objective:
Green Synthesis of Silver Nanoparticle Using Parmotrema parmutatum Extract and Its Application in Colorimetric Sensing

Results:
The silver nanoparticle synthesized was confirmed by a color change and the maximum
peak of the SPR band was at 420 nm in the UV spectrum. The crystal has face-centered cubic (FCC)
structure with an average size of 12.78 nm. The lichen extract contains polyphenolic groups which
act as capping agents. synthesized silver nanoparticles were used to detect formaldehyde and hazardous
Hg2+ ions separately. A color change was observed. The detection limit of Hg2+ was 600 μL.
Likewise, silver nanoparticles were used to degrade methylene blue. The blue color of methylene
blue disappeared. The efficiency of silver nanoparticles was found to be 72% in 4 hours and 87.82%
in 24 hours.

Conclusion:
Parmotrema permutatum has the potential to reduce Ag2+ to Ago and acts as a capping
and stabilizing agent, it can be used to biosynthesize silver nanoparticles and can detect formaldehyde,
and Hg2+ ions, in addition, it also degrades methylene blue photolytically.
Promoting Patient Engagement in Adverse Drug Reaction Reporting: A Novel Approach Utilizing Set Induction-Based Skill Questionnaires
Authors: T Y Sree Sudha , Kumari Kusum , Kumar Hansraj , Kankarwal Monika , Sasanka KSBS Krishna 
Published: August 2024

Background:
All stakeholders must address the global health concern of an increasing
frequency of adverse drug reactions (ADRs), regardless of the practice settings. Adverse
drug reactions have been found to be a significant cause of morbidity and death across all age
groups, hospital admissions, and a significant financial burden on society and healthcare systems.
The main objective of this study was to measure patients' awareness and knowledge of reporting
adverse drug reactions using a questionnaire and then to help patients become more
aware of and sensitive to reporting ADRs.

Methods:
The current investigation was carried out in the OPD Block of the All India Institute
of Medical Sciences in Deoghar using a pre-experimental study with one group pre-test post-test
design. One hundred and ninety-nine patients who were visiting different OPDs and IPDs participated
in this study.

Results:
The average age of the 199 study participants was 34.6 years. The majority of participants
were male, illiterate and belonged to rural areas. We found a statistically significant difference
[-11.90(0.000*)] in the pre-test and post-test knowledge questionnaire scores of the participants,
indicating the efficacy of awareness and sensitization for patients on ADR reporting.

Conclusions:
This survey aims to inform patients about the pharmacovigilance Program in India.
The questions are structured in a way that allows patients to reflect and become more selfaware
while reading them. They also function as a set introduction to ADR (Adverse Drug Reaction)
monitoring centers and increase patient awareness of reporting ADRs.
Clinical Efficacy and Safety of CD7-Targeted CAR T Cell Therapy for T-cell Malignancies: A Systematic Review and Meta-analysis
Authors: Dashti Mohsen , Habibi Mohammad Amin , Nejati Negar , Robat-Jazi Behrouz , Ahmadpour Mahsa , Dokhani Negar , Nejad Aida Rezaei , Karami Shaghayegh , Alinejad Erfan , Malekijoo Amir H. , Ghasemzadeh Afsaneh , Jadidi-Niaragh Farhad 
Published: August 2024

Objectives:
Although T-cell malignancies are relatively less prevalent compared to B-cell malignancies,
they are highly malignant, and patients usually have poor prognoses. Employing CD7-targeted chimeric
antigen receptor (CAR) T cell therapy as a novel immunotherapy to treat malignant T cells faces numerous challenges
and is in its early phase. To evaluate this possibility, we aimed to review and meta-analyze the related
clinical trials systematically.

Methods:
On October 9, 2023, the online databases of PubMed, Scopus, Embase, and Web of Science were systematically
searched for pertinent studies. After completing a two‐step title/abstract and full-text screening process,
the eligible studies were included.

Results:
We observed a pooled overall response rate (ORR) of 100%. Partial response (PR), stringent and/or
complete response (sCR/CR), and relapse rate were 6%, 85%, and 18%, respectively. Additionally, the pooled
rate of minimal residual disease (MRD) negativity was 85%. The most common grade ≥3 adverse events were
related to hematological toxicities, including neutropenia (100%), thrombocytopenia (79%), and anemia (57%).
Cytokine release syndrome (CRS) was also a frequent complication with a 100% rate; however, 81% of CRS
events were low grades. No grade ≥3 GVHD was reported, and the immune effector cell–associated neurotoxicity
syndrome (ICANS grade ≥3) was rare (4%).

Conclusion:
CD7 is an active and safe target that shows promising results in the treatment of relapsed and/or
refractory (r/r) T-cell malignancies.