bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic engineering of Corynebacterium glutamicum for increasing the production of l-ornithine by increasing NADPH availability
Authors: Jiang Ling-Yan , Zhang Yuan-Yuan , Li Zhen , Liu Jian-Zhong 
Published: July 2013

Abstract
The experiments presented here were based on the conclusions of our previous proteomic analysis. Increasing the availability of glutamate by overexpression of the genes encoding enzymes in the l-ornithine biosynthesis pathway upstream of glutamate and disruption of speE, which encodes spermidine synthase, improved l-ornithine production by Corynebacterium glutamicum. Production of l-ornithine requires 2 moles of NADPH per mole of l-ornithine. Thus, the effect of NADPH availability on l-ornithine production was also investigated. Expression of Clostridium acetobutylicum gapC, which encodes NADP-dependent glyceraldehyde-3-phosphate dehydrogenase, and Bacillus subtilis rocG, which encodes NAD-dependent glutamate dehydrogenase, led to an increase of l-ornithine concentration caused by greater availability of NADPH. Quantitative real-time PCR analysis demonstrates that the increased levels of NADPH resulted from the expression of the gapC or rocG gene rather than that of genes (gnd, icd, and ppnK) involved in NADPH biosynthesis. The resulting strain, C. glutamicum ΔAPRE::rocG, produced 14.84 g l−1 of l-ornithine. This strategy of overexpression of gapC and rocG will be useful for improving production of target compounds using NADPH as reducing equivalent within their synthetic pathways.
Carbon cycling and sequestration in a Japanese red pine (Pinus densiflora) forest on lava flow of Mt. Fuji
Authors: Ohtsuka Toshiyuki , Negishi Masaya , Sugita Kazuyuki , Iimura Yasuo , Hirota Mitsuru 
Published: July 2013

AbstractBiometric‐based carbon flux measurements were conducted in a pine forest on lava flow of Mt. Fuji, Japan, in order to estimate carbon cycling and sequestration. The forest consists mainly of Japanese red pine (Pinus densiflora) in a canopy layer and Japanese holly (Ilex pedunculosa) in a subtree layer. The lava remains exposed on the ground surface, and the soil on the lava flow is still immature with no mineral soil layer. The results showed that the net primary production (NPP) of the forest was 7.3 ± 0.7 t C ha−1 year−1, of which 1.4 ± 0.4 t C ha−1 year−1 was partitioned to biomass increment, 3.2 ± 0.5 t C ha−1 year−1 to above‐ground fine litter production, 1.9 t C ha−1 year−1 to fine root production, and 0.8 ± 0.2 t C ha−1 year−1 to coarse woody debris. The total amount of annual soil surface CO2 efflux was estimated as 6.1 ± 2.9 t C ha−1 year−1, using a closed chamber method. The estimated decomposition rate of soil organic matter, which subtracted annual root respiration from soil respiration, was 4.2 ± 3.1 t C ha−1 year−1. Biometric‐based net ecosystem production (NEP) in the pine forest was estimated at 2.9 ± 3.2 t C ha−1 year−1, with high uncertainty due mainly to the model estimation error of annual soil respiration and root respiration. The sequestered carbon being allocated in roughly equal amounts to living biomass (1.4 t C ha−1 year−1) and the non‐living C pool (1.5 t C ha−1 year−1). Our estimate of biometric‐based NEP was 25 % lower than the eddy covariance‐based NEP in this pine forest, due partly to the underestimation of NPP and difficulty of estimation of soil and root respiration in the pine forest on lava flows that have large heterogeneity of soil depth. However, our results indicate that the mature pine forest acted as a significant carbon sink even when established on lava flow with low nutrient content in immature soils, and that sequestration strength, both in biomass and in soil organic matter, is large.
A review on Relation Extraction with an eye on Portuguese
Authors: de Abreu Sandra Collovini , Bonamigo Tiago Luis , Vieira Renata 
Published: July 2013

AbstractThe task of Relation Extraction is one of the main challenges in Natural Language Processing. We present a review of the state-of-the-art for Relation Extraction in free texts, addressing the progress and difficulties of the area, and situating Portuguese in that frame. We discuss the different aspects related to this task, considering the main computational strategies, used resources, as well as the evaluation methods applied. We also give special attention to the literature for Portuguese tools, which need further progress. On the best of our knowledge, this is the first comprehensive survey on Relation Extraction to include the state of the work done for Portuguese.
295 – Gender Differences in Determinants of Suicidal Ideation in French Speaking Community Living Older Adults in Canada
Authors: Vasiliadis H.-M. , Gagné S. , Préville M. 
Published: July 2013

Background:Determinants of suicidal ideation in females and males may differ in older adults.Objectives:To ascertain gender specific determinants of suicidal ideation.Methods:Data used in this study was from the ESA survey on a large representative sample of community dwelling older adults (n=2494). Multivariate logistic regression analysis was used to study the association between suicidal ideation, mental health service and antidepressant use and a number of clinical and socio-demographic factors.Results:The prevalence of suicidal ideation reached 6.3%. The findings of this study show that the presence of suicidal ideation in females is associated with younger age, single or widowed status, the reporting of daily life stressors and chronic conditions as well as the presence of depression. In males, suicidal ideation is associated with older age, single or widowed status and depression. Furthermore, suicidal ideation is significantly associated with antidepressant use in females but not males and this after controlling for a number of clinical factors.Conclusion:Although no gender differences are observed between suicidal ideation and mental health service use, females with suicidal ideation are more likely to be dispensed antidepressants than males with suicidal ideation. The more prevalent use of antidepressants in females with suicidal ideation may lead to better management of symptoms related to depression and their consequences at an earlier stage of the disorder.
316 – The Study of Precedent Child Abuse's Relation with Misuse of Substances in Adulthood
Authors: Rezaei Ghalechi E. , Rahim Zadeh Y. , Ahadi B. , Narimani M. 
Published: July 2013

Introduction:Child abuse is one ofthe important problems all over the word.Objectives:The purpose of this research is study of the effect of child abuse on misuse of substances in adulthood.Aim:The examinees of this research are persons that were engaged to misuse of substances.Methods:The examinees that have conditions according to DSM-IV and international diagnostic interview (CLDL) organization of therapeutic services title of aim groups in individuals and groups form were selected. For normal study of scores distribution of Colomugro of Smirnouf for study of relationship between researches variables of Pearsonian and for comparison and for comparison between groups of Levins test analysis variance test.Results:The results of the investigation show that P < 0.036 and r= 0.617) in arrangement : affective child abuse: P< 0.029,r=0.669 neglect child abuse : P< 0.045 and r=0.587 physical child abuse: P< 0.022 and r=0.694 sexual child abuse P< 0.012 and r=0.797). Also the results of this research show that the relationship between child abuse and time of substances use was P< 0.043 and r= 0.555 in arrangement: affective child abuse : P< 0.046 and r=0/0521,neglect child abuse : P< 0.027 and r=0.681 physical child abuse, P< 0.041 and r=0.575 sexual child abuse : p< 0.032 and r=0.634 only between sexual child abuse and species of substances was meaningful (P< 0.000) in sum.Conclusion:The results of this research show that the existence of precedents child abuse is important cases that individuals in adulthood inclined to the addiction.
321 – Survey Relationship Between History of Child Abuse and Mental Health in Adulthood
Authors: Rezaei Ghalechi E. , Kazemi R. 
Published: July 2013

Introduction:Child abuse is important reason of children 's problems in the future.Objectives:Finding the origins of future problems in people's life is one of the our objects.Aim:The present study with aim predicted adult mental health based on experiences of child abuse during childhood was conducted.Methods:In this study 294 patients (164males and 130 females) students with sampling randomly and with using random numbers table were selected. To measure the variables of the questionnaires Goldberg general health (GHQ), Cooper smith self-esteem and Beck depression were used. Data analysis using person correlation test and multiple regressions were performed simultaneously.Results:Findings showed that there is significant relationship between histories of physical, emotional child abuse and neglected with mental health and adults with a history of Physical, emotional abuse and neglected in terms of mental health are much lower. between sexual abuse and mental health, there is no significant relationship and only emotional child abuse and neglect are able predict significantly mental health scores also showed there is no significant relationship and only emotional child abuse and neglect are able to significantly predict depression scores.Conclusion:Based on the findings of this study was found between physical emotional abuse neglect and anxiety there is significant relationship while between sexual child abuse with anxiety there is no significant relationship and just emotional child abuse is able to significantly predict anxiety scores. In sex factor results showed that there is significant relationship between mental health of male and female victims.
322 – Study Recurrence Causes of Mental Diseases Among Hospitalized Patients in Ardabil
Authors: Rezaei Ghalechi E. , Sadeghi Movahhed F. 
Published: July 2013

Introduction:Most of the hospitalized mental patients have background of past medical history.Objectives:Regarding the recurrence feature of the psychological diseases prevention and the causes of recurrence have gained a special importance.Aim:This prompted us to make a survey of the causes of the return of the psychological diseases.Methods:This retrospective study covered 200 cases that 100 of which gathered from men's ward and 100 of them from women. based on the cases the questionnaire including the demographic information nine main causes of return and 2 variables of the times of recurrent including up to 3 times recurrent and more than it were completed.Results:The patients under study were 36.5 years old in average from among 100 female patients. 42 cases suffered from schizophrenia 42%, 23 cases (23%) BMD,28cases 28% major depression and 7 cases 7% OCD. From among 100 male patients 50 cases 50% suffered from schizophrenia 22 cases 22% BMD, 18 cases 18% major depression and 10 cases 10% OCD.Conclusion:This study shows that men suffered from schizophrenia more than women suffered major depression more than men. the cause of the recurrence of diseases include avoiding to use drugs,unknown,divorce,economic problems, family problems, immigration, the death of a beloved one, abandoning, child, pregnancy. The percent of each has been different in different kinds of diseases but in both sexes avoiding the use of drugs has been the major cause of recurrence in mental diseases.
323 – The Study of Personality Components Style in Ordinary Women and Women Sacrificed by the Home Indelicacy
Authors: Rezaei Ghalechi E. , Sadeghi Movahhed F. 
Published: July 2013

Introduction:Women's Mental health has important section about their personalities.Objectives:We are comparing the personalities of women to each other in different conditions and jobs.Aim:The aim of this study is the comparison of attachment styles and personality sides between women who are victims of domestic violence and ordinary women.Methods:This research included all of them who had complained to family court at first 150 people were randomly studied amid mentioned community by domestic violence questionnaire that 50 people were selected as main annoyed ones were examined in terms of population variable for analysis of data descriptive statistics and k2 and multi-variable variance analysis were used.Results:Achievements expresses that there is a difference between annoyed and ordinary women in terms of attachments styles also it was unfolded that annoyed women vary with those who are ordinary in terms of characteristic sides and it means that annoyed women got higher marks than ordinary ones at aggression point of view and it is mentionable that the difference between 2 groups is significant.Conclusion:Accounts of unsafe attachments styles at annoyed women is one of the reasons which cause reluctant interaction in sexual affairs, then lessens loyalty and kindness levels in joint life and finally leads to disruptive behaviors as violence annoyed women with high aggression low desired level, lack of flexibility and low extrovert personality decrease enjoyment of joint life and satisfaction level in sexual life and with a continues contradictions justify the account of domestic violence.
326 – Survey of ADHD Prevalence among College Students Reside in Hostel of Ardabil Medical University
Authors: Rezaei Ghalechi E. , Sadeghi Movahhed F. 
Published: July 2013

Introduction:Attention Deficit - Hyper Activity Disorder.(ADHD) is a heredity and psychological disorder that often continues to adulthood and causes great number of emotional, social, educationaland occupational problem for college students.Objectives:We think there is a meaningful relation between ADHD and people's jobs and conditions.Aims:The aim of this study isdetermine the prevalence of ADHD among students reside in hostel ofArdabil University of Medical Sciences.Methods:In this cross sectional study selected all studentsin hostel of Ardabil University of Medical Sciences and all of them fill theSelf reporting Conners ADHD questionnaires and the data wereextracted and analyzed with SPSS.Results:During this study the prevalence of ADHD is 8.6 percent, and themale gender shows more involvement rate than female and the involvedStudents show more incidences of smoking and psychotropic drugconsumption.Conclusions:According to the high prevalence of ADHD among collegeStudents, diagnosis and treatment of ADHD as soon as possible appearsis necessary.
356 – Social Determinants of Decision on Nasal Plastic Surgery in Young Adults
Authors: Fararouei M. , Niknam M. , Kamkar A. , Mohammadi A. , Fooladi N. 
Published: July 2013

Objectives:Cosmetic surgery in Iran is suggested to be the most common. The aim of this study was to determine the social factors affecting decision on undergoing nasal cosmic surgery.Materials and methods:100 participants were enrolled in this study (50 participants undergone nasal surgery and 50 controls who had no intention to apply for plastic surgery. Controls were selected among friends and relatives of the surgery group and were matched for sex, age (±1year), marital status, income and education (in the same category as surgery group).A self administered questionnaire was used to measure social and family factors namely: having a car, having a house, father's job, mother's job, the participant birth order, out of marriage sexual contact, and number of sisters. Multivariate logistic was used to analysis the data.Results:Among the factors used in the final model only number of sisters shown a positive and significant association with application for nasal surgery (P = 0.019).Conclusion:Being adjusted for monthly income and no significant association with the participant's father's or mother's job (social class of the participants) may explain the high rate of cosmic surgery among Iranian population. While matched for sex, a direct and significant association between number of sisters of the participants and undergoing plastic surgery suggests the importance of family members and their gender in making decision on undergoing nasal cosmic surgery.
390 – Introduction of “modified Early Warning Score” (mews) to a Learning Disability Ward
Authors: Shaddel F. 
Published: July 2013

Background:Modified Early Warning Scores (MEWS) are now commonly used for the assessment of unwell patients in general hospitals. It can be used to quickly identify the deteriorating patients who need urgent intervention. The use of MEWS has been shown to be effective in reducing mortality and morbidity of patients who deteriorate slowly. Its use in mental health has not been thoroughly studied.Methodology:Standard MEWS form was reproduced and customized for using in psychiatric wards. A survey was conducted on level of confidence of Chiltern unit's nursing staff before and after introducing the MEWS form.They were asked to make a decision about management of two standard case studies and rate their level of self confidence from 1 to 5 before and after using the form.Results:10 nursing staff band 5 and 6 took part in this study with wide range of experience from 6 months to 20 years (Average 9.7 years).The average level of confidence before introducing MEWS was 3.65± 0.66 and rose to 4.6±0.5 afterward. The improvement in the level of confidence was statistically significant (P = 0.002).The validity of decisions made by nursing staff about two cases rose from 45% before using the form to 100% afterward. The improvement in the validity of decision making after introduction of MEWS system was also statistically significant (P< 0.0001).Conclusion:Our study suggests promising potentials for improvement in patients’ safety and confidence of nursing staff by introducing MEWS system to in-patient psychiatric wards.
393 – The Effectiveness of Medical Student Well-being Workshop to Improve Medical Students’ Psychological Distress Symptoms
Authors: Yusoff M.S.B. , Esa A.R. , Noor S.H. , Yaacob M.J. 
Published: July 2013

Introduction:Many researchers have emphasized the importance of teaching stress management and self-care skills to medical students as they are vulnerable to develop psychological health problems.Aims:To explore potential effects of a 4-hour stress management intervention on medical students’ psychological health.Objective:To determine changes of psychological distress symptoms between the intervention and control groups.Method:A randomized controlled trial study was conducted in a medical school. Out of 500 medical students who were randomly invited to participate in this study, 171 medical students consented. They were randomly assigned into the study groups. Their psychological distress symptoms were measured by the DASS-21 at five different intervals. The Repeated Measure ANCOVA was performed to determine the effects of intervention.Results:A total of 153 medical students (intervention = 73 and control = 80) completed this study. There was a significant reduction of the symptoms among the intervention group at different intervals (p = 0.007). The intervention group experienced significantly lower psychological distress symptoms than the control group (p = 0.011). The effect size was -0.43, indicating the symptoms were significantly improved by 43% of a standard deviation as a result of the intervention. The effects were sustained for duration of 32 weeks post intervention.Conclusion:The results support the effectiveness of the brief intervention to improve psychological health of medical students. It is a promising intervention to be adopted by medical schools as it consumes minimal amount of time, money and man power as well as simple to be implemented.
402 – An Association Study on Children with Gilles de la Tourette’s Syndrome and COMT Gene Polymorphism
Authors: Weidong J. , Jinhua S. , Lanting G. , Aihua Y. 
Published: July 2013

Objective:To investigate the association between catechol-O-methyl transferase (COMT) gene polymorphism and Gilles de la Tourette’s syndrome (GTS).Methods:Using Amplification Refractory Mutation System(ARMS) PCR genotyping assay method, a polymorphism (val158met) of COMT gene was genotyped in 112 of all GTS patients including 54 GTS-alone patients, 48 GTS+ADHD patients among of them and 71 healthy controls. The correlation between positive association of polymorphism (val158met) of COMT gene in GTS and the age of onset in patients with GTS was also analyzed.Results:When compared with healthy controls, genotype of val158met did not differ in total GTS patients or alone- GTS patients (x2=0.56, P = 0.756; x2= 1.05, P = 0.600 respectively). There is also no significant difference (P>0.05) in allele distribution of val158met in total GTS patients or alone- GTS patients when respectively compared with controls (x2= 0.18, P = 0.669; x2= 0.29, P = 0.593 respectively). However, Genotype distribution of val158met was significantly different between GTS+ADHD patients and controls (x2=6.35, P = 0.041). The frequency of the val allele of this locus was significantly higher in GTS+ADHD patients than those in controls (x2= 5.49, P = 0.019).The age of onset in children with GTS having the val/val genotype of COMT gene val158met polymorphism were significantly earlier than no val/val genotype (P = 0.016).Conclusion:Polymorphism (val158met) of COMT gene may be associated with GTS children with comorbid ADHD, which may play an important role to make the age of onset in children with GTS become earlier.
405 – Population Risk Factors in Emergency/disaster Work
Authors: Anderson K.L. , Madrid P. 
Published: July 2013

In order to most effectively work in post-disaster situations it is important to know which people are at greatest risk (Caldera et al., 2001) in order to implement treatment options to reduce the incidence of prolonged mental health adversity. The proposed presentation will discuss four groups within populations affected by disaster or conflict that present as the most vulnerable for mental health concerns. These are children, those with prior mental illness, women, and the elderly. We will provide examples of ways in which highlighting the needs and strengths of these vulnerable populations can lead to better outcomes for overall post-disaster recovery.Primarily, due to a natural dependence on others, children are at particular risk (Belfer, 2006). Often with somatic complaints and regressive behaviours (Dogan-Ates, 2010), their internal state can be the most difficult to interpret. Similarly, for those with pre-existing mental health concerns, obtaining care post-disaster, equal to what is normally provided, can be problematic since the varying degrees of psychiatric facilities are often destroyed, leaving patients without protection, medication or social support (Silove, 2000). When addressed by mental health professionals post-disaster, intervention for these two groups can be complex.Furthermore, as a consequence of an often invisible, but historical pre-existing gender inequality, which affects the vulnerability of women and girls (Meertens, 2010; Pavlish & Ho, 2009), this group become high risk for psychiatric instability. Their safety is paramount to recovery, as is the case of elderly persons whose declining health leaves them exposed to vulnerability and post-traumatic stress responses.