bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytical solutions for nonequilibrium bioheat transfer in tumor during magnetic nanoparticles hyperthermia
Authors: Alqahtani Zuhur , Abbas Ibrahim 
Published: July 2024

Abstract
This paper presents mathematical responses for the dual-phase-lag (DPL) hypothesis, which accounts for nonequilibrium heat transfer during magnetic nanoparticle hyperthermia in tumor. To get this precision, volume averaging is used for the local instantaneous energy formulation for tissues and blood. This study proposes a hybrid numerical strategy to solve this problem by combining change of variables, improved discretization techniques, and Laplace transforms. Using the Arrhenius formulas, the range of denatured proteins is used to assess the degree of heat damages to the tumor and healthy tissues. The impacts of porosity, the blood perfusion and metabolism on the temperature and the thermal injuries are studied. The numerical estimations of temperature and the resulting of thermal injuries are shown on a graph, and a comparison with earlier research establishes the results’ validity.
Association between perinatal and obstetric factors and early age at diagnosis of type 1 diabetes mellitus: a cohort study
Authors: Negrato Carlos A. , Martins Rodrigo L. de M. , Louro Marina D. , Medeiros Gabriel A. , Lanzarin João V.M. , Zajdenverg Lenita , Lopes Lucas C.P. 
Published: July 2024

Abstract

Objectives
To evaluate the association between perinatal and obstetric factors as potential triggers for the early onset of T1DM.

Methods
This was a retrospective cohort study enrolling 409 patients diagnosed with T1DM, in Bauru, São Paulo, Brazil, from 1981 to 2023. Data were retrieved from medical records, regarding sociodemographic parameters as age, sex, ethnicity, and socioeconomic status. Perinatal and obstetric factors as delivery type, gestational age, filiation order, length of exclusive breastfeeding, maternal age, maternal and fetal blood types, and occurrence of maternal gestational diabetes were also analyzed. An adapted survival analysis was employed to gauge the impact of each assessed variable at the age of T1DM diagnosis.

Results
The median age of T1DM diagnosis was 10.3 years with an interquartile range between 6.4 and 15.5 years. Delivery type and filiation order were the only factors statistically significantly associated with an early age at T1DM diagnosis. Patients who were born through cesarean section and who were firstborns showed a 28.6 and 18.0 % lower age at T1DM diagnosis, respectively, compared to those born through vaginal delivery and those that were nonfirstborns.

Conclusions
Being born by cesarean section and being firstborn showed to be statistically significant factors to determine an early T1DM diagnosis.
Biodegradable cannabidiol: a potential nanotherapeutic for neuropathic pain
Authors: Qayum Sana , Schmitt Rebecca R. , Machhar Janvhi S. , Garg Sonali , Bass Caroline , Muthaiah Vijaya P. K. , Ignatowski Tracey A. , Mahajan Supriya D. 
Published: July 2024

Abstract
Cannabidiol (CBD) is a promising pharmaceutical agent to treat pain, inflammation, and seizures without the psychoactive effects of delta-9-tetrahydrocannabinol (THC). While CBD is highly lipophilic and can cross the blood-brain barrier (BBB), its bioavailability is limited and clearance is quick, limiting its effectiveness in the brain. To improve its effectiveness, we developed a unique nanoformulation consisting of CBD encapsulated within the biodegradable and biocompatible polymer, methoxy polyethylene glycol-poly(lactic-co-glycolic acid) (mPEG-PLGA). mPEG-PLGA-CBD nanoparticles exhibited negligible cytotoxicity over a range of concentrations in CCK-8 assays performed in human astrocytes and brain microvascular endothelial cells. Furthermore, in an in-vitro BBB model, they exhibited rapid BBB permeability without harming BBB integrity. An in vivo Chronic Constriction Injury animal pain model was employed to study the efficacy of mPEG-PLGA-CBD in doses 1, 3 and 10 mg/kg, and it was found that 45–55 nm CBD nanoparticles with an encapsulation efficiency of 65 % can cross the BBB. Additionally, 3 and 10 mg/kg mPEG-PLGA-CBD nanoformulation provided prolonged analgesia in rats on day 2 and -4 post-injection, which we propose is attributed to the sustained and controlled release of CBD. Future studies are required to understand the pharmacokinetics of this nanoformulation.
Combination of generic novelty detection and supervised classification pipelines for industrial condition monitoring
Authors: Klein Steffen , Wilhelm Yannick , Schütze Andreas , Schneider Tizian 
Published: July 2024

Abstract
Machine learning in industrial condition monitoring is currently a rapidly developing field of research, to improve the efficiency and reliability of industrial processes. Many of the used algorithms are supervised methods, which can learn and recognize hidden patterns in the data. However, training data is required to learn these patterns, which can only be generated to a limited extent in an industrial environment due to the high costs involved. Furthermore, it is impossible to represent all possible events in the training data. In contrast, unsupervised or semi-supervised methods can be used to detect new conditions or events. However, these usually do not allow diagnosis or quantification of a fault condition, which is why their usefulness for modern maintenance strategies is limited. Consequently, a robust condition monitoring system should combine the functionality of both approaches. This paper presents a methodology for the combination of supervised classification and semi-supervised novelty detection to build an expandable and adaptable condition monitoring by transferring recurring novelties as new conditions to the supervised classification. A superordinate algorithm is proposed to achieve a stepwise extension of the supervised model based on new conditions detected by novelty detection. With this approach, a condition monitoring system can at first be based on “normal” data of a new machine or process by adding failures or novel conditions step-by-step. Furthermore, the supervised methods can be used to help the corresponding staff identify unknown conditions by analyzing the features selected by the supervised classification. The general workflow is demonstrated for condition monitoring of the pneumatic drive system of a welding gun.
I. Die Herzmetaphorik im babylonischen Vertragsrecht – Ina ḫūd libbišu und der freie Wille beim Kaufvertrag
Authors: Kleber Kristin , Kirchhefer-Lauber Anna 
Published: July 2024

Summary
Metaphor theories can provide new methodological means for the analysis of Akkadian cuneiform legal documents, especially with regard to the interpretation of terms and legal concepts in Babylonian contracts. In this article we examine the metaphorical phrase of ina ḫūd libbišu (from/in the joy of his heart), which becomes a terminus technicus in the Neo-Babylonian contracts and show that it did not only supersede the traditional waiver of action clauses but also introduced a real voluntative element, by which a seller consented to the transfer of ownership.
II. In Civitate: Captivity and Inheritance in Tannaitic Halakha in Light of Roman Law
Authors: Malka Orit , Paz Yakir 
Published: July 2024

Summary
The question of the influence of Roman law on tannaitic legal literature, composed in Roman Palestine from the first to the third centuries CE, is currently the focus of an intense scholarly debate. While some argue for a deep link between rabbinic and Roman legal discourse, others regard the impact of Roman law on the rabbis as merely superficial. The current article aims to contribute to this debate by presenting a case study that demonstrates a high level of engagement, by some rabbis, with Roman legal discourse, one that goes well beyond superficial borrowing. In this case study, a rabbinic ruling regarding the inheritance of captives is shown to depend heavily on Roman juristic discourse over the ramifications of the Lex Cornelia de captivis. In a sophisticated process of reworking, the rabbis adapt Roman legal materials and principles into a rabbinic framework. Most importantly, we show that this reworking includes the reappropriation of a native tannaitic term (‘in the medina’) in order to translate a Roman technical legal term (in civitate), infusing the Hebrew term with new legal meanings. The details of this case study reveal what is normally concealed: the self-awareness of the rabbis who handle a Roman legal literary source, most probably derived from a concrete juristic discourse, deliberately reworking it to accord with rabbinic terminology, style, and form. This was probably not a one-time process, and it could well have been standard practice among some of the rabbis. Thus, this case study suggests that the evidence for a dramatic impact of Roman legal discourse on tannaitic halakha might be hiding in plain sight.
VI. The colonate in the west of Europe after ca. 500 AD
Authors: Sirks A. J. B. 
Published: July 2024

Summary
The colonate as it was established under Diocletian depended on the credit an estate owner provided to a farmer. The latter had to provide at any moment services instead of interest and consequently had to reside in or near the estate. If the credit was used for the poll tax and the credit agreement was inserted into the census of the estate, the colonate in its public law form was created. It involved also a change in the status of the colonus. The subservience to the estate owner made his status into one of a subjected status which passed on to the offspring. In the east abolition of the poll tax implied the lifting of the colonate. In the west, in provinces of the former West-Roman Empire, we see in the sixth century a colonate which is hereditary but which has to all appearances no connection with the poll tax, if that still existed. It seems that a group of law texts which only deal with the descent of coloni was interpreted as standing on their own, not connected with taxation. In this way, it is submitted, the colonate shed its fiscal component and became a category of mere personal law.
VII. Der Index des Thalelaios zu C. 4,44,15 und die laesio enormis
Authors: Kaiser Wolfgang 
Published: July 2024

Summary
The article deals with the question of the date of the laesio enormis (C. 4,44,2.8.12. 15), according to which the seller can cancel the purchase if the purchase price does not even reach half the value of the object of purchase, but the buyer can avert this by paying the shortfall. To answer this question, a hitherto overlooked source, the index of Thalelaios to C. 4,44,15, is consulted. The index reproduces the wording of C. 4,44,15 in the Codex of the year 529. The text agrees in part with CTh. 3,1,4 and in part with C. 4,44,15 in the Codex repetitae praelectionis. The similarities with CTh. 3,1,4 show that the price limit did not exist in the Codex of the year 529. It does not go back to Diocletian, but was inserted by the second Codex commission, which orientated itself on two of Justinian’s constitutions. An appendix deals with the question of the place where Diocletian was when C. 4,44,2 was issued in November 285.
Inhalt: I. Einleitung. – II. Das Gesetz des Kaisers Gratianus vom 2. Mai 383 im Codex Theodosianus (CTh. 3,1,4), S. 353. – III.C. 4,44,2. 8 und 15 im Codex repetitae praelectionis, S. 359, 1. Zur Überlieferung von C. 4,44 De rescindenda venditione, 2. C. 4,44,2 (Diocl.; a. 285), a) Zur Textkonstitution von C. 4,44,2, b) Zum Inhalt von C. 4,44,2, 3. C. 4,44,8 (Diocl.; a. 293), a) Zur Textkonstitution von C. 4,44,8, b) Zum Inhalt von C. 4,44,8; 4. C. 4,44,12 (Diocl.; a.?); 5. C. 4,44,15 (Gratianus; a. 383). – IV. Der Index zu C. 4,44,15 (Bas. 19,10,84), S. 372, 1. Überlieferung und Text des Index zu C. 4,44,15, 2. Die Abweichungen des Index von CTh. 3,1,4 und C. 4,44,15, 3. Folgerungen. – V. Die Einfügung der Wertgrenze durch die zweite Codexkommission, S. 380. – VI. Folgerungen für C. 4,44,8.12 und 2, S. 384, 1. Zur Rekonstruktion von C. 4,44,8, 2. Zur Rekonstruktion von C. 4,44,12, 3. Zur Rekonstruktion von C. 4,44,2, a) Weitere Texteingriffe der zweiten Codexkommission?, aa. Rem maioris pretii, bb. tu vel, cc. Emptoribus/emptor, dd. humanum est, b) Das mögliche Kriterium für eine Rückabwicklung, c) Zur Rechtsgrundlage der Rückabwicklung. – VII. Anderweitige Spuren des Codex 1. Auflage in Werken aus dem justinianischen Rechtsunterricht, S. 404, 1. Der Codex Iustinianus im Rechtsunterricht, a) Die Kaiserkonstitutionen im Rechtsstudium, b) Vorlesungszeiten und Inkrafttreten der 1. und 2. Auflage des Codex, 2. Unterricht zum Codex des Jahres 529 und des Jahres 534, 3. Reste von Vorlesungen zum Codex 1. Auflage: Erklärungsmodelle, a) Aufgabe und Kompetenzen der ersten und zweiten Codexkommission, b) Verwendung veralteten Materials oder redaktionelle Fehler?, 4. Beispiele für Divergenzen der lateinischen und indirekten griechischen Überlieferung, a) C. 4,14,3, b) C. 8,53,2, c) C. 7,65,5, d) C. 3,36,25. – VIII. Ergebnisse, S. 424, Anhang: Zum Erlassort von C. 4,44,2
VIII. Die sogenannte Epitome Guelferbitana der Lex Romana Visigothorum
Authors: Liebs Detlef 
Published: July 2024

Summary
or (Alaric’s) Breviary, has survived, following the oldest version of the Lex Salica, in a manuscript from about 760 ad, now in Wolfenbüttel. The Epitome probably originates from mid 6th century in northern Burgundy, and may have been drafted by an instructor of law. It stands out thanks to its practical handling of the later Roman law at that time and environment, adapting traditional regulations to contemporary demands.
Nochmals zu D. 19,1,23 (Iul. 13 dig.) = Iul. 221 Lenel
Authors: Platschek Johannes 
Published: July 2024

Summary
Julian’s solution of a sales law case as transmitted in D. 19,1,23 has often been described as erroneous, leading to a purchaser’s double compensation ex empto. It has been suggested that the fragment is interpolated and Julian was originally talking about actio fiduciae. Avoiding both an error by Julian as well as the suspicion of interpolation, this article tries to give another explanation, reinforcing aspects that have already been emphasized within the long lasting scholarly discussion and proposing a reconstruction of a lost element of Julian’s text.
Resistenz des talmudischen Rechts gegenüber dem römischen Recht?
Authors: Forster Doris 
Published: July 2024

Summary
It is sometimes assumed that Talmudic civil law was barely more than a copy of Roman law. Rabbis indeed lived in a Roman-law environment and a superficial look at Talmudic and Roman law does reveal many similarities. However, an attentive analysis of the rules on liability for animals unveils Talmudic law’s single characteristics and indeed its resistance to external influences in this context; most likely the rabbis endeavoured to preserve the independence of Talmudic law from the secular ruling authority rather than conforming with it.
Zum Text von D. 1,16,6pr. (Ulp. 1 off. procons.) = Ulp. 2144 Lenel
Authors: Platschek Johannes 
Published: July 2024

Summary
The governor of a senatorial province (proconsul) can delegate iurisdictional power to his legati (iurisdictio mandata). He cannot transfer ius gladii and coercitio, nor the power to release a criminal suspect from custody. The governor’s practice however, as described by the transmitted text of D. 1,16,6pr., taken from Ulpian’s De officio proconsulis, is held to be interpolated. Reexamination of the passage shows there is no need to suppose any manipulation of the text with regards to content.
REVISTA NUESTRA ESPAÑA: A CONSTITUIÇÃO DE UMA REDE INTELECTUAL ANTIFRANQUISTA NO EXÍLIO CUBANO
Authors: Gonçalves Marcos 
Published: July 2024

O artigo reconstitui parte da história do exílio republicano espanhol em Cuba, após a guerra-civil no país ibérico (1936-1939). Situa como recorte temático analisar o periódico que consiste na primeira publicação de intelectuais espanhóis no exílio: a revista Nuestra España, criada em outubro de 1939 na cidade de Havana por Alvaro de Albornoz (1874-1954), exilado em Cuba, e fundador em Espanha do Partido Republicano Radical-Socialista em 1929. O texto adota duas ideias-chaves como impulsoras dos argumentos descritivos e explicativos: 1) a noção de "redes", ou "redes intelectuais no exílio", enquanto conceito operativo que define o intercâmbio discursivo e tensional entre textos coletivos, ou como conjunto de relações entre as escrituras, e não propriamente como aquilo que se estabelece enquanto singular performatividade de um autor; 2) uma narrativa inaugural do antifranquismo produzida desde o exílio, hipótese defendida a partir da constatação sobre o vínculo predominante e coesão entre a rede de intelectuais, e que se constitui como núcleo irradiador das interpretações sobre o franquismo. Em outros termos, o antifranquismo se realiza como vasto conjunto de interpretações concebidas em um “lugar” distanciado das mediações culturais de origem, e que passam a refutar não só as mitologias políticas que configuravam o esteio da ditadura franquista, mas também denunciavam a economia de terror implantada em Espanha.
Chromosomal missegregation and aberrant embryo development in repro57 female mice with Rnf212 homozygous mutation
Authors: Sono Nanami , Takeshita Mone , Chikushi Mizuho , Nakashima Saki , Miyawaki Shoko , Wakamatsu Misaki , Fujiwara Yasuhiro , Kunieda Tetsuo , Otsuki Junko 
Published: July 2024

In brief
Repro57 mice, bearing an Rnf212 gene mutation, exhibit infertility in both homozygous mutant males and females, revealing arrested spermatogenesis in males and investigating unclear mechanisms in females. The study highlights aneuploidy and altered kinetochore patterns in repro57 homozygous mutant oocytes, which impact later stages of embryo development.

Abstract
Repro57 mice, induced with N-ethyl-N-nitrosourea and harboring a mutation in the Rnf212 gene, exhibit infertility in both homozygous mutant males and females. Rnf212 plays a crucial role in recombination and crossover designation. In male repro57 homozygous mutants, spermatocytes often degenerate during late prophase, and mature spermatozoa are absent in the seminiferous epithelium, indicating arrested spermatogenesis as the cause of infertility. Despite reports of infertility in Rnf212-knockout female mice, the specific mechanisms underlying infertility in female repro57 homozygous mutants remain elusive. This study investigates the chromosomal and kinetochore patterns of mature oocytes and their developmental potential following in vitro fertilization in female repro57 homozygous mutant mice. While all wild-type oocytes progress to metaphase II and exhibit euploidy, all repro57 homozygous mutant mouse oocytes display aneuploidy. Additionally, kinetochore distances in repro57 homozygous mutant oocytes exceed those observed in wild-type counterparts. Although no significant differences are noted in fertilization and early embryo development rates between wild-type and repro57 homozygous mutant mice, embryos derived from repro57 homozygous mutants exhibit significantly lower morula and blastocyst rates, accompanied by frequent cytokinesis failure and vacuole formation. These findings suggest that the premature segregation of sister chromatids in repro57 homozygous mutant mice adversely impacts the later stages of embryo development.
Instituto de victimología: un espacio de formación para la paz desde la Universidad Santo Tomás
Authors: Porras Moreno Jeisson Fabián , Gamboa Sánchez Audrey Nicol 
Published: July 2024

Desde su fundación en el 2011, el Instituto de Victimología de la Universidad Santo Tomás seccional Bucaramanga surge como respuesta al compromiso de protección y acompañamiento a las víctimas del conflicto armado interno, desde la academia en el marco de un contexto que exige la participación activa de todos los actores sociales dentro de la construcción de paz. Por lo tanto, a través del desarrollo de sus diferentes áreas de acción, ha venido fortalecido su compromiso en pro de la garantía los derechos de las víctimas, los derechos humanos, la reconciliación y la paz.

El trabajo del Instituto de Victimología se ha caracterizado por la articulación con diferentes sectores académicos, públicos y comunitarios en la generación de acciones y estrategias que permitan responder a los contextos jurídicos, políticos y sociales propios de la transición. Una muestra de esto se refleja en el trabajo articulado con entidades públicas como la Jurisdicción Especial para la Paz (JEP), la Unidad para las Víctimas, la Agencia para la Reincorporación y la Normalización, y administraciones municipales, quienes han brindado su apoyo, desde el 2022 y lo corrido del 2024, para la capacitación y formación de los cerca de 129 jóvenes estudiantes que hacen parte de la Ruta de Atención Integral para las Victimas (RAIV) y los integrantes de las Estrategias de Formación en Ciencia, Tecnología e Innovación adscritas al Instituto de Victimología y a la Facultad de Derecho.
Direitos humanos e o poder judiciário
Authors: Oliveira Jacques Carla , Da Luz Oliveira Jairo 
Published: July 2024

O presente estudo busca evidenciar os campos correlacionais de tensão e contradição entre os Direitos Humanos e a justiça no âmago da sociedade brasileira. A partir de uma revisão bibliográfica, refletimos sobre o direito a partir do método dialético-crítico. Realiza-se uma reflexão sobre o Poder Judiciário e as contradições inerentes ao processo de judicialização da questão social, buscando subsidiar os profissionais do Serviço Social que se inserem em demandas de judicialização da sociedade na busca por seus direitos individuais, sociais e coletivos.
Development of Problem-Based Learning Teaching Materials to Improve Mathematical Problem Solving Ability and Self-Efficacy Students
Authors: Safitri Dhiena , Napitupulu E. Elvis , Khairani Nerli 
Published: July 2024

AbstrakPenelitian ini bertujuan; Penelitian ini bertujuan untuk menganalisis: keabsahan bahan ajar pembelajaran berbasis masalah untuk meningkatkan kemampuan pemecahan masalah dan Self-Efficacy matematis siswa; kepraktisan bahan ajar tersebut; dan keefektifan proses pembelajaran dengan menggunakan TEAC. Menilai Self-Efficacy siswa setelah memanfaatkan bahan ajar. Penelitian ini merupakan penelitian pengembangan. Penelitian ini memiliki dua tahap yaitu merancang bahan ajar pembelajaran berbasis masalah dengan menggunakan paradigma pengembangan Four-D dan mengevaluasinya di kelas X IPS di salah satu SMAN di Kota Medan. Hasil penelitian menunjukkan bahwa: Profesional menganggap bahan ajar pembelajaran berbasis masalah valid, praktis, dan efektif. Self-Efficacy matematis siswa meningkat dari uji coba I ke uji coba II setelah memanfaatkan sumber belajar berbasis masalah