bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of Known and Unknown Primary Tumor Sites In Spinal Metastasis Patients
Authors: Paholpak Permsak , Sirichativapee Winai , Wisanuyotin Taweechok , Kosuwon Weerachai , Jeeravipoolvarn Polasak 
Published: October 2012

Study Design:
A retrospective study.

Objectives:
Three objectives have been designated for this study: (1) to determine the prevalence of identifiable and non-identifiable primary tumor sites in patients with spinal metastasis, (2) to identify the most common site of the known primary tumor sites, and (3) to identify the factors associated with survival time.

Summary of Background Data:
The spine is the third most common metastatic site for several primary visceral carcinomas. The primary tumor site could not be identified in 15% to 20% of patients who had been diagnosed of with a skeletal metastasis. Most of the previous studies on skeletal metastasis have not been limited to spinal metastasis alone.

Methods:
Between January 2007 and July 2011 reviews were done for 82 patients with spinal metastasis who had not received a previous diagnosis of carcinoma. The assessment parameters included the following: general demographic data, Karnofsky score, Frankel score, number of spinal vertebra affected, region of the spine affected by metastasis, other skeletal metastasis site, visceral metastasis, known or unknown primary sites of metastasis, histological cell type of metastasis, and the survival period. The log-rank test and Cox proportional hazard model were used to study the survival analysis.

Results:
Of the 82 patients included in the study, 56 were male. The mean age was 57 years. 86.6% had a known primary carcinoma site while the remaining 13.4% had none. The two most common known carcinoma sites were the lung and biliary systems. Among the 11 unknown primary sites, the most common histological finding was adenocarcinoma. The mean survival period was 8.7 ± 11.7 months. The survival analysis revealed two statistically significant factors: the primary tumor site’s aggressiveness (P<0.005) and the presence of visceral metastasis (P<0.05).

Conclusion:
The prevalence of identifiable primary site was 86.6% and the most common site was the lungs followed by the biliary system. The primary carcinoma site’s aggressiveness and the presence of visceral metastasis were the factors associated with patient survival.
Factors related to alveolar bone thickness during upper incisor retraction
Authors: Yodthong Nuengrutai , Charoemratrote Chairat , Leethanakul Chidchanok 
Published: October 2012

ABSTRACTObjective:To investigate the factors related to changes in alveolar bone thickness during upper incisor retraction.Materials and Methods:The subjects consisted of 23 ongoing orthodontic patients (mean age 20.4 ± 2.7 years) whose upper incisors were bound for retraction. Changes in alveolar bone thickness in the retracted area were assessed using preretraction (T0) and postretraction (T1) cone-beam computed tomography images. Labial bone thickness (LBT), palatal bone thickness (PBT), and total bone thickness (TBT) were assessed at the crestal, midroot, and apical levels of the retracted incisors. Paired t-tests were used to compare T0 and T1 bone thickness measurements. Spearman's rank correlation analysis was performed to determine the relationship of changes in alveolar bone thickness with the rate of tooth movement, change in inclination, initial alveolar bone thickness, and the extent of intrusion.Results:As the upper incisors were retracted, the LBT at the crestal level and TBT at the apical level significantly increased (P &lt; .005). Changes in alveolar bone thickness were significantly associated with the rate of tooth movement, change in inclination, and extent of intrusion (P &lt; .05) but not initial alveolar bone thickness (P &gt; .05).Conclusion:Rate of tooth movement, change in inclination, and extent of intrusion are significant factors that may influence alveolar bone thickness during upper incisor retraction. These factors must be carefully monitored to avoid the undesirable thickening of alveolar bone.
Comparison of geostatistical approaches dealing with the distribution of snow
Authors: Prusova Marketa , Orlikova Lucie , Hanzlova Marketa 
Published: October 2012

Abstract
This paper deals with a stochastic simulation. Snow cover, representing a regionalized variable, was studied and used as an input parameter for a stochastic simulation. The first step included basic statistical analysis of individual parameters of snow, e.g. snow height. In the next step, an analysis of relationships between the snow and the geomorphological parameters (altitude, slope and aspect) was conducted. The most current methods of spatial interpolation and multifactor evaluation are based on weighted regression relationships. Primarily, the use of conditional stochastic simulation was tested in a variety of software. The main aim of this investigation is to compare selected interpolation methods with stochastic simulation, based on the development of the values and on the evaluation of the incidence of extreme events. The study shall provide users with recommendations for selecting the optimal interpolation method and its application to real data.
Charcoal and pollen analyses and vegetation reconstruction of the Alpine foreland in West Hungary
Authors: Náfrádi Katalin , Sümegi Pál , Törőcsik Tünde 
Published: October 2012

Abstract
In the area of archaeological excavations that were performed prior to the construction of Main Road No. 86 in Vas County (West Hungary) in the Alpine foreland new geoarchaeological analyses have been conducted. We used anthracology and pollen analyses to reconstruct the former vegetation cover at the study site. Charcoal data provide site-related information about the local woodland composition, management and human impact, while pollen data provide information on the arboreal and non-arboreal vegetation on a regional or local scale. Adequate samples for anthracological analyses derive from the Bronze Age, Iron Age, Imperial and Migration Periods and Middle-Ages archaeological objects. The core for pollen analyses originates from alluvial sediments of the Borzó Creek and covers the late Pleistocene and the Holocene until the Medieval Period. Charcoal analyses show the dominance of Quercus trees in the vicinity of the human settlements that might indicate a strong human selection, or the fragmentation of samples. Pollen analyses indicate thermophilous vegetation from the beginning of the Holocene, with increasing values of Fagus and Carpinus. Pollens of cereals indicate human activity, which is also demonstrated by the presence of pollen from Juglans and Vitis in the Iron Age sequence. Extensive forest clearance occurred in the Late Iron Age and the Imperial Period.
Cognitive and Brain Development in Adolescence
Authors: Keating Daniel P. 
Published: October 2012

Résumé La théorie piagétienne des opérations formelles a inauguré le travail empirique sur le développement cognitif de l’adolescent. Ce lancer a abouti à deux résultats principaux. D’une part, il n’y a pas eu confirmation de stades, d’âge d’acquisition ni de conditions logiques spécifiques ; d’autre part, des recherches se sont développées sur les mécanismes sous-tendant les changements liés à l’adolescence. Des changements importants concernent la vitesse de traitement, la mémoire de travail, le contrôle inhibiteur, les capacités de planification stratégique, toutes capacités en rapport avec les fonctions exécutives. Les recherches montrent en particulier que les progrès exécutifs concernent davantage les domaines de plus grande expertise...Plus récemment, on note un focus sur la cognition de l’adolescent dans des modèles duels faisant une distinction entre la pensée heuristique et la pensée analytique plus exigeante, et entre une fonction exécutive raisonnée ( cold ) ou spontanée ( hot ) selon le degré d’investissement émotionnel et social. Les modèles de traitement duels et les neurosciences développementales s’accordent sur le rôle de la myélinisation dans la vitesse de traitement, sur le développement accéléré du système limbique, sur la prédominance du cortex préfrontal (PFC) dans le jugement et pour l’orchestration des autres systèmes neuraux. Les données expérimentales cognitives confirment. Dans le futur, la relation directe entre le développement cognitif et le développement cérébral sera sans nul doute privilégiée, avec les rapides progrès des technologies d’imagerie.
NEW STRATEGIES FOR STEM CELL MOBILIZATION
Authors: Lemoli Roberto 
Published: October 2012

Mobilized peripheral blood (PB) is widely used as source of stem cells (PBSCs) for autologous stem cell transplantation (ASCT). The use of cytokines, alone or in combination with chemotherapy (chemomobilization), is the most common strategy applied to mobilize and collect PBSCs. However, a significant proportion of cancer patients fail to mobilize enough PBSCs to proceed to ASCT. Plerixafor is a small molecule that reversibly and transiently disrupts the interaction between the chemokine receptor CXCR4 and its ligand CXCL12 (formerly known as stroma derived factor 1, SDF-1) leading to the rapid release of CD34+ hematopoietic stem cells from the bone marrow (BM) to PB. Plerixafor has been recently approved to enhance PBSC mobilization in patients with multiple myeloma or non-Hodgkin lymphoma and has been shown to be more effective than G-CSF alone. There is limited experience on combining plerixafor with chemotherapy plus G-CSF in patients who mobilize poorly. Current evidence suggests that the addition of plerixafor is safe and effective in the large majority of the patients with low blood CD34+ cell count after mobilization and/or poor yield after the first collection(s). Circulating CD34+ cells can be increased by several folds with plerixafor and the majority of the patients considered “poor mobilizers” can be successfully collected. Overall, its mechanism of action inducing the rapid release of CD34+ cells from the BM to the circulation makes plerixafor suitable for the ‘pre-emptive’ use in patients who are hard-to-mobilize.
Efficient Energy Stable Schemes with Spectral Discretization in Space for Anisotropic Cahn-Hilliard Systems
Authors: Chen Feng , Shen Jie 
Published: October 2012

AbstractWe develop in this paper efficient and robust numerical methods for solving anisotropic Cahn-Hilliard systems. We construct energy stable schemes for the time discretization of the highly nonlinear anisotropic Cahn-Hilliard systems by using a stabilization technique. At each time step, these schemes lead to a sequence of linear coupled elliptic equations with constant coefficients that can be efficiently solved by using a spectral-Galerkin method. We present numerical results that are consistent with earlier work on this topic, and also carry out various simulations, such as the linear bi-Laplacian regularization and the nonlinear Willmore regularization, to demonstrate the efficiency and robustness of the new schemes.
Fekete-Gauss Spectral Elements for Incompressible Navier-Stokes Flows: The Two-Dimensional Case
Authors: Lazar Laura , Pasquetti Richard , Rapetti Francesca 
Published: October 2012

AbstractSpectral element methods on simplicial meshes, say TSEM, show both the advantages of spectral and finite element methods, i.e., spectral accuracy and geometrical flexibility. We present aTSEM solver of the two-dimensional (2D) incompressible Navier-Stokes equations, with possible extension to the 3D case. It uses a projection method in time and piecewise polynomial basis functions of arbitrary degree in space. The so-called Fekete-Gauss TSEM is employed,i.e., Fekete (resp. Gauss) points of the triangle are used as interpolation (resp. quadrature) points. For the sake of consistency, isoparametric elements are used to approximate curved geometries. The resolution algorithm is based on an efficient Schur complement method, so that one only solves for the element boundary nodes. Moreover, the algebraic system is never assembled, therefore the number of degrees of freedom is not limiting. An accuracy study is carried out and results are provided for classical benchmarks: the driven cavity flow, the flow between eccentric cylinders and the flow past a cylinder.
Numerical Solution of Acoustic Scattering by an Adaptive DtN Finite Element Method
Authors: Jiang Xue , Li Peijun , Zheng Weiying 
Published: October 2012

AbstractConsider the acoustic wave scattering by an impenetrable obstacle in two dimensions, where the wave propagation is governed by the Helmholtz equation. The scattering problem is modeled as a boundary value problem over a bounded domain. Based on the Dirichlet-to-Neumann (DtN) operator, a transparent boundary condition is introduced on an artificial circular boundary enclosing the obstacle. An adaptive finite element based on a posterior error estimate is presented to solve the boundary value problem with a nonlocal DtN boundary condition. Numerical experiments are included to compare with the perfectly matched layer (PML) method to illustrate the competitive behavior of the proposed adaptive method.
The Product Liability Directive and Rome II Article 5: ‘Full Harmonisation’ and the Conflict of Laws
Authors: Whittaker Simon 
Published: October 2012

AbstractThis article considers the possible relationship between EU legislation governing private international law and legislation governing substantive law in the light of recent moves towards ‘full harmonisation’ and calls for greater consistency and coherence in European law-making. For this purpose, it considers the Product Liability Directive and the special product liability provisions in Article 5 of the Rome II Regulation on the law applicable to non-contractual obligations and asks how the understanding of ‘product liability’ compares in these two instruments, especially in relation to the distinctions between public and private law, general and special regulation and contract and tort.
Brussels I and Third States: Future Imperfect?
Authors: Fentiman Richard 
Published: October 2012

AbstractIn December 2010 the European Commission published its long-awaited proposals for the reform of the Brussels I Regulation on civil jurisdiction and the enforcement of judgments. These concern matters of considerable practical importance. But they also expose fundamental questions about the Regulation’s proper scope, and its role in complex commercial disputes, which will persist long after the terms of the amended Regulation are settled.
Identifying an Unlawful Margin Squeeze: The Recent Judgments of the Court of Justice in Deutsche Telekom and TeliaSonera
Authors: Jones Alison 
Published: October 2012

AbstractThe chapter will consider what a margin squeeze is, whether it is appropriate for a competition authority to try and prevent margin squeezes using competition law rules and, if so, what tests can be used to identify an unlawful margin squeeze and to distinguish it from legitimate competition on the merits.
To Bail Out Or Not to Bail Out?—Legal Aspects of the Greek Crisis
Authors: Hofmeister Hannes 
Published: October 2012

AbstractSince the precarious state of Greece’s public finances was revealed last October, efforts to save the ‘cradle of Europe’ are in full swing. Hence a huge rescue package for Greece was agreed on in April 2010. This was followed by an even larger EU Stabilisation Fund worth €750 billion for States encountering financial problems. While the economic aspects of these rescue mechanisms have been debated intensively, their legality has escaped closer examination. Rushed through parliaments as an ‘economic emergency’, the peoples of Europe were more or less presented with a ‘fait accompli’. But are these measures really legal under EU law? What about the notorious ‘no bailout’ clause? And what about the alternatives to the rescue packages: Would it have been legal to withdraw from EMU? Or to expel a State from EMU? This chapter will shed some light on these important aspects of EU law.
What is in an Index? A View from a European Orientated Lawyer
Authors: Samuel Geoffrey 
Published: October 2012

AbstractAnyone familiar with French legal education will know that what a common lawyer would call the contents page to be found at the beginning (often in summary form) or at the end (often in detail) of a French textbook or monograph on law is more than a mere guide for browsers and readers. It forms le plan, that is to say the epistemological framework the intellectual importance of which is equal to the substance of the work. It is what endows the book with its scientific credibility and any thesis or textbook lacking a coherent cartesian plan will by definition lack intellectual credibility. But what of the other guide provided in many academic books, namely the index? Is this guide nothing but a guide, never to be allowed to aspire to an epistemological status like that accorded to le plan? Or is an index, with its strictly alphabetical ordering, capable of having an epistemological role?
Constitutional Identity as a Shield and as a Sword: The European Legal Order within the Framework of National Constitutional Settlement
Authors: Konstadinides Theodore 
Published: October 2012

AbstractThe pitfalls of the relationship between European and national judges constitute a well-travelled ground in literature, especially with regard to ‘sagas’ over the reconciliation of national sovereignty with EU law primacy. Hence, the contribution that this article is attempting to make is to explore the judicial understanding and potential of the concept of constitutional identity in the light of the newly-introduced Article 4(2) TEU by the Treaty of Lisbon, which makes it explicit that national identity encompasses constitutional specificity. A number of questions are raised and discussed. For instance: How has the Court of Justice of the European Union (CJEU) been adjudicating on issues pertaining to the constitutional identity of the Member States pre- and post-Lisbon? How far can Member States stretch the concept to avoid the tidal effect of EU law upon their legal systems? For the sake of clarity, two notions of constitutional identity are identified and presented in this article: One related to the CJEU’s case law, where ‘constitutional identity’ has been invoked by defending Member States as a qualified derogation from their EU law obligations (a ‘shield’) and another, inherent in the German Constitutional Court’s (BVerfG) use of ‘constitutional identity’ as a break to an unprecedented transfer of competences to the EU and a tool of judicial review of national implementation measures of secondary legislation (a sword). The arguments advanced hereafter suggest that the implications of identity retention as a ‘shield’ may not be far-reaching since the CJEU has, through a pragmatic use of the loyalty and proportionality principles, succeeded in reducing its effect to the bare minimum. On the other hand, as a judicial review mechanism, the German paradigm demonstrates that, as a ‘sword’, constitutional identity retention comprises, largely, a theoretical possibility. These assumptions aside, it is concluded that constitutional identity retention may provide both national judiciaries and legislatures with new opportunities to participate in trans-national constitutional development through monitoring and assessing the compatibility of the exercise of EU competence with the requirements of national constitutions.
‘A Risk of Irreparable Damage’: Interim Measures in Proceedings before the European Court of Human Rights
Authors: McCormick Pamela 
Published: October 2012

AbstractInterim measures can be indicated by most international decision-making bodies which monitor compliance with human rights norms to the parties involved in the proceedings before them, in order to prevent the commission of any irreversible actions which would either preclude the proper examination of a complaint or render the final judgment meaningless. The availability of interim measures is an essential feature of any effective judicial system, particularly where fundamental rights are at stake. They play a particularly important role in proceedings before the European Court of Human Rights (‘the Court’). The volume of requests for an indication of interim measures received by the Court each year is substantial and increasing. This presents the Court with a number of legal and practical problems. This chapter examines the circumstances in which an indication of interim measures may be made, as well as the consequences of non-compliance with such an indication, although it is acknowledged that the incidence of non-compliance is low. With its recent case law, the Court has brought the existence of interim measures to the attention of a wider audience, which is desirable as only such an awareness will render the protection of Convention rights practical and effective rather than theoretical and illusory, a stated goal of the Court. However, such a wider awareness will in turn increase the volume of requests again, making it likely that the Court will in years to come have to make significant changes to the scope of requests for interim measures, as well as to its practices and procedures for considering such requests.
Transparency and Clear Legal Language in the European Union: Ambiguous Legislative Texts, Laconic Pronouncements and the Credibility of the Judicial System
Authors: Sharpston Eleanor 
Published: October 2012

AbstractThe legal system of the European Union generates particular problems of opacity and lack of clarity. This chapter seeks to identify some of the causes of those problems. First, the nature of the texts with which the Court of Justice deals—’Union legislation’, orders for references from national courts and submissions to the Court—is examined. Problems here include the multi-lingual and multi-cultural backgrounds of those involved in the process, vagueness in legislative drafting and lack of clarity in references and submissions placed before the Court. Secondly, the Court’s own judgments and the opinions of its Advocates General are considered. Problems here include the factors governing the drafting of a single consensus judgment and the fact that it is not always easy to strike the correct balance between speed and quality. Lastly, a number of suggestions for change are offered. The obstacles are not insuperable and improvements can be made.
Revisiting the Posted Workers Directive: Conflict of Laws and Laws in Contrast
Authors: Evju Stein 
Published: October 2012

AbstractThe Posted Workers Directive was controversial from the outset, and the recent case law from the Court of Justice has made it even more so. In this chapter, the backdrop, genesis, drafting and adoption of the Posted Workers Directive are first considered in turn in order to place it in its context. The Court of Justice’s case law is then considered and contrasted with this background and elaboration of the Directive as it was adopted. The present situation under the Posted Workers Directives is also compared with public international law norms, ILO Conventions and the European Social Charter, and the impact of the Directive in Scandinavia is considered. It is concluded that the case law of the Court of Justice is problematic because of the fact that a normative framework results from its decisions which impinges upon fundamental features of collective labour law and industrial relations: it both entails restrictions on the kinds of terms and conditions of employment which can be imposed, and encroaches upon freedom of collective bargaining more broadly. The autonomy of Member States is also limited and the effectiveness of national industrial relations regimes compromised, which is a highly undesirable outcome.