bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why are non-radial solar eruptions less frequent than radial ones?
Authors: Liu Qingjun , Jiang Chaowei , Feng Xuesheng , Zuo Pingbing , Wang Yi 
Published: June 2024

ABSTRACT
Coronal mass ejections from the Sun are not always initiated along a radial trajectory; such non-radial eruptions are well known to be caused by the asymmetry of the pre-eruption magnetic configuration, which is primarily determined by the uneven distribution of magnetic flux at the photosphere. Therefore, it is naturally expected that the non-radial eruptions should be rather common, at least as frequent as radial ones, given the typically asymmetrical nature of photospheric magnetic flux. However, statistical studies have shown that only a small fraction of eruptions display non-radial behaviour. Here we aim to shed light on this counterintuitive fact, based on a series of numerical simulations of eruption initiation in bipolar fields with different asymmetric flux distributions. As the asymmetry of the flux distribution increases, the eruption direction tends to deviate further away from the radial path, accompanied by a decrease in eruption intensity. In case of too strong asymmetry, no eruption is triggered, indicating that excessively inclined eruptions cannot occur. Therefore, our simulations suggest that asymmetry plays a negative role in producing eruption, potentially explaining the lesser frequency of non-radial solar eruptions compared to radial ones. With increasing asymmetry, the degree of non-potentiality the field can attain is reduced. Consequently, the intensity of the pre-eruption current sheet decreases, and reconnection becomes less efficient, resulting in weaker eruptions.
Formation of the inner Oort cloud in the presence of an early solar binary
Authors: Raush Dennis , Batygin Konstantin 
Published: June 2024

ABSTRACT
Consistent with the notion that most Sun-like stars form in multistellar systems, this study explores the impact of a temporarily bound stellar binary companion on the early dynamical evolution of the Solar system. Using N-body simulations, we illustrate how such a companion markedly enhances the trapping of scattered bodies on inner Oort cloud-like orbits, with perihelion distances exceeding $q \gt 40$ au. We further find that the orbital geometry of the Sun-binary system plays a central role in regulating the efficiency of small-body implantation on to high-perihelion orbits, and demonstrate that this process is driven by the von Zeipel–Kozai–Lidov mechanism. Incorporating the transiency of stellar clusters and the eventual Sun-binary pair dissociation due to passing stars, we show how the binary can be stripped away by an approximately solar-mass ejector star, with only a modest impact on the generated inner Oort cloud population. Collectively, our results highlight a previously underappreciated process that could have contributed to the formation of the inner Oort cloud.
Clinicogenomic predictors of outcomes in patients with hepatocellular carcinoma treated with immunotherapy
Authors: Cowzer Darren , Chou Joanne F , Walch Henry , Keane Fergus , Khalil Danny , Shia Jinru , Do Richard K G , Yarmohammadi Hooman , Erinjeri Joseph P , El Dika Imane , Yaqubie Amin , Azhari Hassan , Gambarin Maya , Hajj Carla , Crane Christopher , Wei Alice C , Jarnagin William , Solit David B , Berger Michael F , O’Reilly Eileen M , Schultz Nikolaus , Chatila Walid , Capanu Marinela , Abou-Alfa Ghassan K , Harding James J 
Published: June 2024

Abstract

Introduction
Immune checkpoint inhibitor (ICI) combinations extend overall survival (OS) while anti-PD-1/L1 monotherapy is non-inferior to sorafenib in treatment-naïve, patients with advanced hepatocellular carcinoma (HCC). Clinicogenomic features are posited to influence patient outcomes.

Methods
The primary objective of this retrospective study was to define the clinical, pathologic, and genomic factors associated with outcomes to ICI therapy in patients with HCC. Patients with histologically confirmed advanced HCC treated with ICI at Memorial Sloan Kettering Cancer Center from 2012 to 2022 were included. Association between clinical, pathological, and genomic characteristics were assessed with univariable and multivariable Cox regression model for progression-free survival (PFS) and OS.

Results
Two-hundred and forty-two patients were treated with ICI-based therapy. Patients were predominantly male (82%) with virally mediated HCC (53%) and Child Pugh A score (70%). Median follow-up was 28 months (0.5-78.4). Median PFS for those treated in 1st line, 2nd line and ≥ 3rd line was 4.9 (range: 2.9-6.2), 3.1 (2.3-4.0), and 2.5 (2.1-4.0) months, respectively. Median OS for those treated in 1st line, 2nd line, and ≥ 3rd line was 16 (11-22), 7.5 (6.4-11), and 6.4 (4.6-26) months, respectively. Poor liver function and performance status associated with worse PFS and OS, while viral hepatitis C was associated with favorable outcome. Genetic alterations were not associated with outcomes.

Conclusion
Clinicopathologic factors were the major determinates of outcomes for patients with advanced HCC treated with ICI. Molecular profiling did not aid in stratification of ICI outcomes. Future studies should explore alternative biomarkers such as the level of immune activation or the pretreatment composition of the immune tumor microenvironment.
The Geography of Investor Attention
Authors: Mengoli Stefano , Pagano Marco , Pattitoni Pierpaolo 
Published: June 2024

Abstract
Local companies attract significantly more attention from investors than nonlocal companies, especially at times of news releases and high volatility. This attention gap widens especially when news is firm-specific rather than aggregate, and in response to idiosyncratic rather than market risk. Attention is causally related to perceived proximity: after a firm is acquired by a nonlocal one, local investors, compared with nonlocal investors, are more likely to reallocate attention away from it; conversely, COVID-19 travel restrictions led investors to reallocate attention toward local companies and away from nonlocal ones, especially those difficult to reach. Finally, local attention predicts volatility, bid-ask spreads, and nonlocal attention, but not vice versa. Our findings suggest that the geography of attention matters and is shaped by local investors’ information-processing advantage, not familiarity bias. (JEL D83, G11, G12, G14, L86, R32)
Received: 2 January 2024; Editorial decision: 13 March 2024 Editor: Isil Erel Authors have furnished an Internet Appendix, which is available on the Oxford University Press Web site next to the link to the final published paper online.
Psychosocial Interventions for Individuals With Comorbid Psychosis and Substance Use Disorders: Systematic Review and Meta-analysis of Randomized Studies
Authors: Siddiqui Salsabil , Mehta Dhvani , Coles Alexandria , Selby Peter , Solmi Marco , Castle David 
Published: June 2024

Abstract

Background and Hypothesis
Substance use is highly prevalent among people with schizophrenia (SCZ) and related disorders, however, there is no broad-spectrum pharmacotherapy that concurrently addresses both addiction and psychotic symptoms. Psychosocial (PS) interventions, which have yielded promising results in treating psychosis and substance dependence separately, demonstrate potential but have not been systematically evaluated when combined.

Study Design
Systematic review and random-effects meta-analyses of randomized controlled trials (RCTs) investigating PS interventions for individuals with comorbid substance use and psychotic disorders, encompassing SCZ and schizophrenia spectrum disorders (SSD). We included relevant studies published from MEDLINE, PsycINFO, and Google Scholar through May 2023.

Study Results
We included 35 RCTs (5176 participants total; approximately 2840 with SSD). Intervention durations ranged from 30 min to 3 years. Meta-analysis did not identify a statistically significant pooled PS intervention effect on the main primary outcome, substance use (18 studies; 803 intervention, 733 control participants; standardized mean difference, −0.05 standard deviation [SD]; 95% CI, −0.16, 0.07 SD; I2 = 18%). PS intervention effects on other outcomes were also not statistically significant. Overall GRADE certainty of evidence was low.

Conclusions
At present, the literature lacks sufficient evidence supporting the use of PS interventions as opposed to alternative therapeutic approaches for significantly improving substance use, symptomatology, or functioning in people with SCZ and related disorders. However, firm conclusions were precluded by low certainty of evidence. Further RCTs are needed to determine the efficacy of PS treatments for people with dual-diagnoses (DD), either alone or in combination with pharmacotherapy.
Facing antisemitism in Europe: individual and country-level predictors of Jews’ victimization and fear across twelve countries
Authors: Enstad Johannes Due 
Published: June 2024

Abstract
Rising antisemitism in the twenty-first century has alarmed Jewish communities and the general public, but antisemitic hate crime victimization remains understudied outside the US context. This study primarily relies on a comprehensive survey of 16,400 Jews across twelve European countries, supplemented with data from additional sources, to assess individual and country-level predictors of Jews’ experiences and fears of antisemitic harassment and violence. Multilevel models indicate that young age, perceived discrimination, identity visibility, and identification with Israel are pronounced individual risk factors for victimization. On the country level, negative opinion of Israel and Muslim population share predict victimization, highlighting the role of a “new” or Israel-derived antisemitism in the twenty-first century. The factors most strongly associated with fear are young age, previous victimization, perceptions of an ambient antisemitic threat, and recent occurrence of fatal antisemitic violence. Overall, the findings underscore the importance of integrating general theory on hate crime and victimization with context-specific factors when seeking to understand the experiences of targeted groups.
Sleep as a contributor to socioeconomic disparities in hypertension: The Midlife in the United States (MIDUS II) Study
Authors: Aqua Jasmine Ko , Barnum Olivia , Johnson Dayna A 
Published: June 2024

Abstract

Study Objectives
Hypertension is highly prevalent and is a major risk factor for cardiovascular disease. There is a higher burden of hypertension among individuals of lower socioeconomic status (SES), yet the role of sleep in understanding socioeconomic disparities in hypertension is unclear. We investigated whether sleep quality is a partial mediator of the association between SES and hypertension.

Methods
We used data from the Midlife in the United States II Study, 2004–2009 (n = 426). Analyses were conducted in 2023. Participants underwent 7-day actigraphy and clinical assessments. Sleep quality measures included actigraphy-defined wakefulness after sleep onset (WASO) and sleep efficiency. Hypertension was measured via three consecutive blood pressure readings, and SES was measured via educational attainment. Models were fit adjusting for age, gender, race, body mass index, and perceived stress.

Results
Participants had a mean age of 53.5 years (SD = 12.4) and 41.0% were African American. The prevalences of poor WASO (&gt;30 minutes), low sleep efficiency (&lt;85%), and hypertension were 77.7%, 67.1%, and 61.0%, respectively. Education was not associated with hypertension. However, individuals with low vs. high sleep efficiency had 24% higher prevalence of hypertension (aPR = 1.24, 95% CI: 1.02 to 1.51), higher systolic blood pressure (aβ = 4.61, 95% CI: 0.69 to 8.53), and higher diastolic blood pressure (aβ = 2.50, 95% CI: 0.10 to 4.89). Education was not significantly associated with sleep after adjustment. There was no evidence of sleep mediating the SES-hypertension relation.

Conclusions
Effective interventions to lower hypertension prevalence should consider targeting sleep quality. Future research should explore the intersectionality of SES and race in hypertension.
Toll‐like receptor 4‐dependent innate immune responses are mediated by intracrine corticosteroids and activation of glycogen synthase kinase‐3β in astrocytes
Authors: Lai Wenfang , Huang Siying , Liu Junjie , Zhou Binbin , Yu Zhengshuang , Brown John , Hong Guizhu 
Published: June 2024

AbstractReactive astrocytes are important pathophysiologically and synthesize neurosteroids. We observed that LPS increased immunoreactive TLR4 and key steroidogenic enzymes in cortical astrocytes of rats and investigated whether corticosteroids are produced and mediate astrocytic TLR4‐dependent innate immune responses. We found that LPS increased steroidogenic acute regulatory protein (StAR) and StAR‐dependent aldosterone production in purified astrocytes. Both increases were blocked by the TLR4 antagonist TAK242. LPS also increased 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) and corticosterone production, and both were prevented by TAK242 and by siRNAs against 11β‐HSD1, StAR, or aldosterone synthase (CYP11B2). Knockdown of 11β‐HSD1, StAR, or CYP11B2 or blocking either mineralocorticoid receptors (MR) or glucocorticoid receptors (GR) prevented dephosphorylation of p‐Ser9GSK‐3β, activation of NF‐κB, and the GSK‐3β‐dependent increases of C3, IL‐1β, and TNF‐α caused by LPS. Exogenous aldosterone mimicked the MR‐ and GSK‐3β‐dependent pro‐inflammatory effects of LPS in astrocytes, but corticosterone did not. Supernatants from astrocytes treated with LPS reduced MAP2 and viability of cultured neurons except when astrocytic StAR or MR was inhibited. In adrenalectomized rats, intracerebroventricular injection of LPS increased astrocytic TLR4, StAR, CYP11B2, and 11β‐HSD1, NF‐κB, C3 and IL‐1β, decreased astrocytic p‐Ser9GSK‐3β in the cortex and was neurotoxic, except when spironolactone was co‐injected, consistent with the in vitro results. LPS also activated NF‐κB in some NeuN+ and CD11b+ cells in the cortex, and these effects were prevented by spironolactone. We conclude that intracrine aldosterone may be involved in the TLR4‐dependent innate immune responses of astrocytes and can trigger paracrine effects by activating astrocytic MR/GSK‐3β/NF‐κB signaling.
Worse Pain and Disability at Presentation Predicts Greater Improvement in Pain, Disability, and Mental Health in Patients Undergoing Minimally Invasive Transforaminal Lumbar Interbody Fusion for Degenerative Spondylolisthesis
Authors: Anwar Fatima N. , Roca Andrea M. , Hartman Timothy J. , Nie James W. , Medakkar Srinath S. , Loya Alexandra C. , MacGregor Keith R. , Oyetayo Omolabake O. , Zheng Eileen , Federico Vincent P. , Sayari Arash J. , Lopez Gregory D. , Singh Kern 
Published: June 2024

Study Design:
Retrospective Review.

Objective:
To assess the impact of preoperative pain and disability on patient-reported outcome measures (PROMs) following minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) for degenerative spondylolisthesis.

Summary of Background Data:
Varying preoperative symptom severity in lumbar fusion patients alters perceptions of surgical success.

Methods:
Degenerative spondylolisthesis patients undergoing elective, primary, single-level MI-TLIF were stratified by preoperative symptom severity: Mild (VAS-B<7/ODI<50), Moderate (VAS-B≥7/ODI<50 or VAS-B<7/ODI≥50), and Severe (VAS-B≥7/ODI≥50). PROMs, Patient-reported Outcomes Measurement Information System-Physical Function (PROMIS-PF), ODI, VAS-B, VAS-Leg (VAS-L), and 9-item Patient Health Questionnaire (PHQ-9) were compared at baseline, 6 weeks, and final follow-up (μ=16.3±8.8 mo). Postoperative PROMs, magnitudes of improvement, and minimal clinically important difference (MCID) achievement rates were compared between cohorts through multivariable regression.

Results:
A total of 177 patients were included. Acute postoperative pain and narcotic consumption were highest in the severe cohort (P≤0.003). All preoperative PROMs worsened from mild to severe cohorts (P<0.001). All PROMs continued to be significantly different between cohorts at 6 weeks and final follow-up, with the worst scores in the Severe cohort (P≤0.003). At 6 weeks, all cohorts improved in ODI, VAS-B, VAS-L, and PHQ-9 (P≤0.003), with the Moderate cohort also improving in PROMIS-PF (P=0.017). All Cohorts improved across PROMs at the final follow-up (P≤0.044). Magnitudes of improvement in ODI, VAS-B, and PHQ-9 increased with worsening preoperative symptom severity (P≤0.042). The Moderate and Severe cohorts demonstrated higher MCID achievement in ODI, VAS-B, and PHQ-9 rates than the Mild cohort.

Conclusions:
Despite preoperative pain and disability severity, patients undergoing MI-TLIF for degenerative spondylolisthesis report significant improvement in physical function, pain, disability, and mental health postoperatively. Patients with increasing symptom severity continued to report worse severity postoperatively compared with those with milder symptoms preoperatively but were more likely to report larger improvements and achieve clinically meaningful improvement in disability, pain, and mental health.
Unveiling the Rarity: CD20 Expression in Mycosis Fungoides and Its Clinical Significance
Authors: Shaker Nada , Sangueza Omar P. 
Published: June 2024

Abstract:
Although CD20 expression is typically scarce in mycosis fungoides (MF), it is more commonly associated with T-cell lymphomas. Nevertheless, isolated instances of CD20-positive MF have been documented infrequently. Here, we present a unique case of CD20-positive MF in a 30-year-old man who manifested with a hypopigmented patch on the anterior chest. Histopathological examination revealed epidermotropic infiltrates of small- to medium-sized lymphocytes with hyperchromatic and cerebriform nuclei aligned along the basal and low-mid layers of the epidermis. Immunophenotypic analysis demonstrated neoplastic T cells expressing CD4+, CD8+, and CD3+ with the loss of CD7. Intriguingly, a notable subset of the neoplastic T cells exhibited CD20 expression. This case contributes to the sparse literature on CD20-positive MF and underscores its diagnostic and clinical ramifications. The role of B cells has been more thoroughly characterized in T-cell lymphomas other than MF. However, its significance in MF remains unclear due to the scarcity of reported cases. Some hypotheses propose that the B cells' expression might indicate immune dysregulation or complex interactions within the tumor microenvironment. Another perspective suggests it could signify a progression of the disease towards a more aggressive lymphoma phenotype. Further investigation and documentation of similar cases is imperative to elucidate the clinical features, prognosis, and optimal therapeutic strategies. The long-term prognosis and outcomes in patients with hypopigmented MF and CD20 positivity remain ambiguous, underscoring the necessity for continued research and scrutiny of analogous cases.
The predictors of intraoperative surgical expenses in liver resection for hepatocellular carcinoma
Authors: Huang Ching-Ting , Lin Chun-Chen , Lee King-Teh , Chang Wen-Tsan 
Published: June 2024

Abstract

Background
This study aimed to clarify the expenses associated with various items and predictors of intraoperative expenses in liver resection for hepatocellular carcinoma (HCC).

Materials and Methods
A total of 562 patients with HCC who underwent liver resection from January 2015 to December 2019 were enrolled in this retrospective study. The direct variables of total intraoperative expenses were the summation of surgeon's fee, anesthetic fee, fees for pharmacy, and disposable supplies, which were analyzed based on surgeons' seniority, patients' demographic features and comorbidity, clinical features of HCC, and complexity of surgery and surgical approach.

Results
Of the total cost, 43.3% accounted for expenses of disposing supplies, 32.8% for surgeons' fees, 15.9% for anesthetic fees, and 8.12% for pharmacy fees. A hierarchical model of multivariate regression analysis showed that the total expenses and that of disposable supplies were significantly higher in surgeons with seniority of over 26 years (P < 0.001) and those having a specialization of robotic surgery (P < 0.001). Further, the complexity and robotic approach of surgery predicted the total expenses (R
2 = 0.862, P < 0.001). Robotic approach and its disposable supplies and major liver resection increased by 93.2% and 20.1% (P < 0.001) of total expenses when compared to open liver resection or partial liver resection, respectively.

Conclusions
The study found that the robotic approach, disposable supplies, and complexity of surgery were the most important predictors of total intraoperative expenses for patients with HCC. Therefore, a cost-effectiveness analysis should be conducted to define the surgical value of the robotic approach for HCC resection.
Prognostic role of suPAR in acute pancreatitis: A protocol for systematic review
Authors: Rehan Syeda Tayyaba , Imran Laiba , Eqbal Farea , Khan Zayeema , Nashwan Abdulqadir J. , Asghar Muhammad Sohaib 
Published: June 2024

Background:
Acute pancreatitis (AP) is a common emergency condition with high morbidity, mortality, and socio-economic impact. Soluble urokinase plasminogen activator receptor (suPAR) is a potential biomarker for AP prognosis. This study systematically reviews the literature on suPAR’s prognostic roles in assessing AP severity, organ failure, mortality, and other pathological markers.

Methods:
A comprehensive search of 5 databases up to March 19, 2023, was conducted, selecting cohort studies that examined suPAR’s relationship with AP outcomes. Outcome variables included AP severity, organ failure, mortality, hospital stay length, and suPAR’s association with other inflammatory markers. Our paper has been registered on Prospero (ID: CRD42023410628).

Results:
Nine prospective observational studies with 1033 AP patients were included. Seven of eight studies found suPAR significantly elevated in severe acute pancreatitis (P < .05). Four studies showed suPAR effectively predicted organ failure risk, and 4 studies concluded suPAR significantly predicted mortality (P < .05). The review had no high-risk studies, enhancing credibility.

Conclusion:
suPAR is a valuable prognostic marker in AP, significantly predicting severity, organ failure, hospital stay length, and mortality. Further large-scale studies are needed to explore suPAR’s role in other clinical outcomes related to AP disease course, to establish it as a mainstay of AP prognosis.